bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors and prognostic factors of brain metastasis of triple-negative breast cancer: A single-center retrospective study
Authors: He Chunyu , Mamuti Guliqihere , Mushajiang Munire , Maimatiniyazi Simayili 
Published: August 2024

ABSTRACT

Objective:
This retrospective study is to explore the risk factors and prognostic factors of brain metastases of triple-negative breast cancer (TNBC) in a single center.

Methods:
Clinical data of patients with stages I–III TNBC were collected. The Kaplan-Meier method, log-rank test, and stepwise COX regression were performed.

Results:
The 437 patients with stages I–III TNBC were followed up for five years. Among them, 89 cases (20.4%) developed brain metastases, and they were followed up for 2 years after brain metastasis. The cumulative brain metastasis rates of TNBC patients at six months, one year, two years, three years, and five years were 1.38%, 5.75%, 12.94%, 17.63%, and 21.26%, respectively. Multivariate analysis suggested that the first diagnosis age ≤35 years old, advanced pathological stage, lymph node metastasis, and Ki-67 ≥30% represented the risk factors for brain metastasis. In contrast, the surgical method was a protective factor for brain metastasis. The median survival time after brain metastasis was 4.87 months. The survival rates at one, three, six, 12, and 24 months were 84.27%, 60.67%, 34.83%, 15.69%, and 6.64%, respectively. The age >60 years at first diagnosis, Ki-67 ≥30%, local recurrence, and distant metastasis were closely related to the poor prognosis of TNBC patients with brain metastases, while radiotherapy alone, systemic therapy, and combined chemotherapy and radiotherapy represented the prognostic protective factors.

Conclusions:
Patient age, Ki-67 level, metastasis, and treatment methods are the risk factors and prognostic factors for brain metastasis of TNBC. Surgical resection of the primary lesion during the first treatment is essential to reduce the incidence of brain metastases. Close postoperative follow-up (such as brain magnetic resonance imaging [MRI]) within 2–3 years after surgery is recommended to improve the prognosis.
The prevalence of multiple or single HPV infection and genotype distribution in healthy Chinese women: A systemic review
Authors: Yu Yanqin , Hao Jinqi , Mohamed S. Bangura , Fu Shilan , Zhao Fanghui , Qiao Youlin 
Published: August 2024

ABSTRACTBackground:We analyzed the prevalence and genotype distribution of multiple- or single-type cervical human papillomavirus (HPV) infections in a population of women in mainland China.Methods:PubMed, MEDLINE, and Chinese databases (CNKI, VIP, and Wan Fang) were searched for studies on HPV prevalence and the examination of this relationship. All analyses were performed using STATA (version 12.0). Data from selected studies were extracted into tables, and all included studies were weighted and summarized.Results:Thirty studies were included. The prevalence of single types (10.4%) and multiple types (4.7%) primarily occurred in healthy Chinese women, in which the dominant single-type infection was HPV16 (1.6%), 52 (1.5%), 58 (1.0%), and 18 (0.5%), and the dominant type of multiple infection was HPV16 (0.7%), 52 (0.7%), 58 (0.6%), and 18 (0.3%). The prevalence in North and South China was 14.3%, in which the prevalence of the single type was 10.41% and 8.27%, and the prevalence of multiple types was 4.00% and 6.52%, respectively.Conclusion:Mainland China exhibits unique type-specific single and multiple HPV infections. Overall single or multiple HPV prevalence varied across regions of China, whereas type-specific HPV differences were relatively small.
Guidelines for permanent iodine-125 seed interstitial brachytherapy for pancreatic cancer (2023 edition): The Chinese expert consensus workshop report
Authors: Liu Bin , Huang Wei , Zhang Fujun , Wang Junjie , Guo Jinhe , Huang Xuequan , Lei Guangyan , Wang Juan , Ye Xin , Wang Ruoyu , Gai Baodong , Hu Xiaokun , Li Maoquan , Li Chengli , Xiao Yueyong , Lin Zhengyu , Niu Lizhi , Zhu Guangyu , Gao Fei , Niu Hongxin , Zhang Hongtao , Wu Qing , Yang Jijin , Zhao Hong , Zhang Kaixian , Chen Zhijin , Chen Tingsong , Zhang Haoren , Wang Zhongmin , Li Yuliang 
Published: August 2024

ABSTRACT
The incidence of pancreatic cancer is increasing worldwide. Approximately, 60% of patients with pancreatic cancer have distant metastases at the time of diagnosis, of which only 10% can be removed using standard resection. Further, patients derive limited benefits from chemotherapy or radiotherapy. As such, alternative methods to achieve local control have emerged, including permanent iodine-125 seed interstitial brachytherapy. In 2023, the Chinese College of Interventionalists, affiliated with the Chinese Medical Doctor Association, organized a group of multi-disciplinary experts to compose guidelines for this treatment modality. The aim of this conference was to standardize the procedure for permanent iodine-125 seed interstitial brachytherapy, including indications, contraindications, pre-procedural preparation, procedural operations, complications, efficacy evaluation, and follow-up.
Sarcopenia as a prognostic factor in patients with hepatocellular carcinoma treated with transcatheter arterial chemoembolization plus sorafenib
Authors: Wang Rujian , Wang Ligang , Jiang Yutian , Dong Mei , Li Mei , Sun Ping 
Published: August 2024

ABSTRACT

Introduction:
Loss of skeletal muscle volume is an important aspect of sarcopenia in hepatocellular carcinoma (HCC) patients treated by surgical resection, transcatheter arterial chemoembolization (TACE), or sorafenib.

Purpose:
This study determined the influence of sarcopenia and other laboratory results on survival in patients with HCC treated with TACE plus sorafenib.

Methods:
The patients were divided into two groups based on the presence of sarcopenia. The skeletal muscle index was calculated by normalizing the cross-sectional muscle area at the L3 level on an abdominal computed tomography scan before embolization according to the patient’s height. The clinical characteristics of the two groups were then compared. The progression-free survival (PFS) and overall survival (OS) rates after treatment were determined.

Results:
Sarcopenia was present in 75 of the 102 (74%) patients with HCC included in this study. The albumin, prealbumin, and cholinesterase levels were lower in those with sarcopenia. The OS (P = 0.001) and PFS (P = 0.008) were significantly prolonged in the nonsarcopenia group compared to the sarcopenia group. Sarcopenia, ECOG (≥2), and prealbumin (<180 mg/L) were significantly associated with PFS. Sarcopenia, ECOG (≥2), Child–Pugh B, BCLC stage C, prealbumin (<180 mg/L), and cholinesterase (<5,320 U/L) were significantly associated with OS. The prognostic factors for OS included sarcopenia, ECOG (≥2), and cholinesterase (<5,320 U/L), whereas only ECOG (≥2) was identified as a prognostic factor for PFS.

Conclusion:
Sarcopenia may be an indicator of poor clinical outcome in patients with HCC receiving TACE plus sorafenib.
An aggressive Cushing’s syndrome originating from a rare thymic neuroendocrine tumor, controlled successfully with fluconazole and octreotide therapy before surgery
Authors: Kargun Sinem , Aydemir Mustafa , Yilmaz Nusret , Gürer İnanc Elif , Sari Ramazan , Altunbas Hasan 
Published: August 2024

ABSTRACT
Cushing’s syndromes (CSs) due to the thymic neuroendocrine tumors are rarely seen. Here, a case of ectopic CS originating from an atypical neuroendocrine tumor has been presented. A 49-year-old woman was hospitalized with symptoms of fatigue, chest pressure, dyspnea, muscle weakness, and resistant hypertension. There was marked hyperpigmentation in the whole-body surface suggestive of adrenocorticotropic hormone (ACTH) excess and there were physical features of CS. There was deep hypokalemia. Basal hormone profile, dexamethasone suppression tests, midnight cortisol, and 24-hour urine cortisol levels were suggestive of ectopic CS. The pituitary magnetic resonance imaging revealed a 5 mm cystic lesion and the patient refused inferior petrosal sinus sampling. Thorax computerized tomography showed an anterior mediastinal mass. A fluorodeoxyglucose-positron emission tomography showed the same mediastinal lesion (suvmax: 11.4), and no other tumor focus was detected. There was an aggressive cortisol excess causing acute respiratory distress syndrome, making it difficult to perform the surgery. We immediately started fluconazole and octreotide therapy and were successful in lowering the cortisol level. Then a complete resection of the tumor had been able to be surgically performed and tumor cells showed strong cytoplasmic immunopositivity with ACTH. A definitive diagnosis of “ACTH secreting atypical thymic carcinoid tumor” was rendered based on the histopathological and immunohistochemical features. There was only surrounding vessel invasion, and no lymphoid or other organ metastases were detected. As there were surrounding vessel invasions, a two-cycle regimen cisplatin-etoposide chemotherapy and radiotherapy were employed. After surgical and medical therapy, the cortisol and ACTH levels turned to normal. The patient is in biochemical and clinical remission and has no tumor recurrence yet. Ectopic ACTH-producing thymic carcinoids are rare but life-threatening tumors because of the underlying malignancy and severe hypercortisolemia. It is important to consider this disease and perform appropriate treatment at the right time. Today, surgery is the standard therapeutic modality if it is possible to perform, but there is not a clear and constant recommendation for nonsurgical therapeutic modalities. Further studies are needed for the optimal treatment strategies.
Clinical efficacy and safety of irreversible electroporation combined with chemotherapy in stage IV pancreatic cancer treatment
Authors: Zeng Jia , Liu Boyu , Lang Xu , Wang Zhe , Fan Yong , Gao Chuntao , Fu Dianxun 
Published: August 2024

ABSTRACT

Purpose:
This study evaluates the clinical efficacy and safety of irreversible electroporation (IRE) therapy combined with chemotherapy in patients with stage IV pancreatic cancer.

Methods:
Between September 2021 and November 2023, we enrolled 38 patients with stage IV pancreatic cancer, with 20 receiving IRE plus chemotherapy and 18 receiving only chemotherapy. We recorded the general information of the patients and regularly followed up postoperative IRE-related adverse reactions. Progression-free survival (PFS) and overall survival (OS) were evaluated during follow-up.

Results:
Median OS was longer in the IRE group than in the chemotherapy group. Median PFS was slightly extended with IRE compared to chemotherapy alone. The mean hospital stay for the IRE group was 5.90 ± 0.75 days. Four serious adverse events occurred after IRE. Postoperative pain scores were significantly lower than preoperative scores.

Conclusion:
IRE combined with chemotherapy showed clinical effectiveness in stage IV pancreatic cancer treatment, offering potential pain reduction benefits with fewer adverse effects and shorter hospital stays.
Exosomes derived from gastric cancer cells promote phenotypic transformation of hepatic stellate cells and affect the malignant behavior of gastric cancer cells
Authors: Zhang Donghuan , Luo Qiong , Xiao Lirong , Chen Xiangqi , Yang Sheng , Zhang Suyun 
Published: August 2024

ABSTRACT

Objective:
This study aimed to evaluate the effect of exosomes derived from gastric cancer cells on the phenotypic transformation of hepatic stellate cells (HSCs) and the effect of HSC activation on the malignant behavior of gastric cancer cells, including its molecular mechanism.

Methods:
Exosomes derived from the human gastric adenocarcinoma cell line AGS were extracted and purified by polymer precipitation and ultrafiltration, respectively. The exosomes’ morphologic characteristics were observed using transmission electron microscopy, particle size was determined through nanoparticle-tracking analysis, and marker proteins were detected using western blotting. Exosome uptake by LX-2 HSCs was observed through fluorescence-based tracing. Reverse transcription quantitative PCR (RT-qPCR) was used to detect the messenger RNA (mRNA) expression of alpha-smooth muscle actin (α-SMA) and fibroblast activation protein (FAP). Using functional assays, the effects of LX-2 HSC activation on the biological behavior of malignant gastric cancer cells were evaluated. The effects of LX-2 HSC activation on the protein expression of epithelial–mesenchymal transition (EMT)-related genes and β-catenin were evaluated via western blotting.

Results:
The extracted particles conformed to the definitions of exosomes and were thus considered gastric cancer cell-derived exosomes. Fluorescence-based tracing successfully demonstrated that exosomes were enriched in LX-2 HSCs. RT-qPCR revealed that the mRNA expression of the cancer-associated fibroblast markers α-SMA and FAP was significantly increased. LX-2 HSC activation considerably enhanced gastric cancer cell proliferation, invasion, and migration. Western blotting showed that the expression of the EMT-related epithelial marker E-cadherin was significantly downregulated, whereas the expression of interstitial markers (N-cadherin and vimentin) and β-catenin was remarkably upregulated in gastric cancer cells.

Conclusion:
Exosomes derived from gastric cancer cells promoted phenotypic transformation of HSCs and activated HSCs to become tumor-associated fibroblasts. Gastric cancer cell-derived cells significantly enhanced gastric cancer cell proliferation, invasion, and migration after HSC activation, which may promote EMT of gastric cancer cells through the Wnt/β-catenin pathway.
To Study a Specific Radiological Pattern of “Diabetic Tuberculosis” (as Described by Sosman and Steidl in 1923) Observed in Patients with Diabetes Mellitus Associated with Pulmonary Tuberculosis
Authors: Jadhav Ulhas S. 
Published: August 2024

Background:
Sosman and Steidl (1923) had described “diabetic tuberculosis” a specific radiological pattern in patients with diabetes mellitus associated with pulmonary tuberculosis. These lesions usually consist of wedge-shaped area of density in which there is often cavitation in the neighborhood of hilum and spreading toward periphery including the bases occurring in diabetics over the age of 40 years. The present study was undertaken to study and highlight this specific radiological pattern of “diabetic tuberculosis” along with the clinical profile of this association.

Materials and Methods:
The present study was carried out in patients with pulmonary tuberculosis admitted to Poona Chest Hospital Aundh Pune, between July 1, 1991, and June 30, 1992. The patients diagnosed as pulmonary tuberculosis were subjected for diabetic status by detailed history, clinical examination, and investigations.

Results:
Among 440 cases of pulmonary tuberculosis prevalence rate of diabetes mellitus was 9.55% (42/440) and a specific radiological pattern “diabetic tuberculosis” was observed in 16.66% (7/42) in diabetics associated with tuberculosis.

Conclusion:
All patients with pulmonary tuberculosis above the age of 40 years should be screened for diabetes and all patients with diabetes should be screened to rule out pulmonary tuberculosis every year. A specific radiological pattern of “diabetic tuberculosis” and lower zone lesions on X-ray observed during clinical examination should be screened to rule out pulmonary tuberculosis as well as diabetes.
Missed Care and Nurses' Job Satisfaction
Authors: Mandal Lata , Seethalakshmi Avudaiappan 
Published: August 2024

Background:
Job satisfaction among nurses is a global concern for its crucial impact on nursing shortage and quality of care. Missed nursing care defined as nurses' decision to omit or delay aspects of patient care activities is hypothesized to influence nurses' job satisfaction.

Aim:
The aim of this study was to explore the relationship between missed nursing care and nurses' job satisfaction.

Materials and Methods:
The study used a cross-sectional design, and data were collected using the MISSCARE survey and Nurses' Work Satisfaction Scale from 205 randomly selected nurses working in the medical–surgical units of four tertiary care hospitals in India. Data were analyzed using IBM SPSS version 23.

Results:
Nurses' job satisfaction was significantly related to missed nursing care, hospital types, and education which together explained 27% of the variance in nurses' job satisfaction.

Conclusion:
Focused strategies to decrease missed nursing care can improve job satisfaction among nurses. Nurse leaders can use missed nursing care as a process indicator to assess and predict nurses' job satisfaction.
Clinicopathological Features of Extranasal Rhinosporidiosis
Authors: Singh Varun Kumar , Bhattacharya Riti , Jaiprakash Padmapriya , Shivamurthy Archana 
Published: August 2024

Aim:
The present series aims to highlight the sites, clinical presentation, histopathological features, anddiagnostic dilemmas of extra-nasal rhinosporidiosis.

Materials and methods:
A review of pertinent demographic and laboratory data for patients diagnosed with extra-nasal rhinosporidiosis, over a period of 7 years (2012- 2019) was done.

Results:
Amongst the 8 cases of extra-nasal rhinosporidiosis, the sites of involvement were medialcanthus (2/8), trachea (2/8), skin and bone (1/8), hard palate (1/8), and concurrent multiple sites (2/8). Clinical differential diagnoses included fungal osteomyelitis, laryngeal papilloma, conjunctival tumor, disseminated rhinosporidiosis, and carcinoma palate. The presence of sporangia, endospores, chronic inflammation, histiocytes was the most consistent histopathological features. Sevencases were managed with a laser-guided excision, and one underwent wide local excision with cauterization. Recurrence was seen in 5/8 cases (62.5%).

Conclusion:
The diagnosis of extra-nasal rhinosporidiosisis often missed due to an unusual site of presentation, or mistaken for a tumor. A proper history and histopathological examination must be carried out in patients with bleeding polyps, especially in an endemic region. The rate of local recurrence is high, which may be reduced by the use of lasers during surgery.
Role of Physiotherapeutic Interventions in Dagdha (Burn) Injuries
Authors: Bele Ashish , Irshad M. Qureshi , Singh Nivedita Chandrapal , Jethwani Divya , Shalaka Dhankar , Madhuri Wane 
Published: August 2024

Background:
In developing countries with low income, one of the most common causes of hospitalization is Dagdha (burn) and it also contributes to secondary problems, such as disfigurement, contractures, and scar tissue development. On the basis of degree/depth of tissues involved the burn may be classified as superficial, superficial partial, and deep partial, deep. Physiotherapists and occupational therapists, as part of the specialist burn multidisciplinary team, have many overlapping expertise and positions in the treatment of burn injury victims by delivering drills and splintering.

Methodology:
The data were collected from the electronic databases, including PubMed, Web of Science, Cochrane Library, EMBASE, Google Scholar, ResearchGate, Springer publications, Statewide Burn Injury Service, McGraw-Hill publications, etc., This review included burn patients of all age groups and both genders.

Results:
This systematic review indicated that physiotherapeutic intervention played a vital role in the management of Dagdha (burn) injury not only to reduce pain and scar but restoring the musculoskeletal and cardiopulmonary functions and making patient functionally independent so that they can enjoy their rest of life independently.

Conclusion:
This systematic review study concluded that physiotherapy played an important role in the management of all types of Dagdha (Burn) injuries of all age groups.
A Novel Code for Coding of Ceramic Prosthesis
Authors: Sathe Seema , Godbole Surekha , Shrivastav1 Sunita , Rajanikanth K. , Bhoyar Anjali , Dhamande Mithilesh 
Published: August 2024

Background:
Forensic dentistry provides identification for the victim in many different scenarios. Data other than the description of the dental condition can be utilized in forensic dentistry like in case of marked dental prosthesis, it can provide important information in cases of major mass disasters where identification of the person becomes a tedious process. The coding system in prosthetic dentistry is available for removable dentures either partial or complete and also for metal crowns. As more people are opting for fixed prosthesis that too for ceramics, the need for having a coding system for ceramic restorations has gained paramount importance. In the current scenario the significance of dental marking or coding system is of vital significance. Removable prosthesis may get dislodged but this is not the case with the fixed prosthesis. Therefore it can play a vital role for identification of the individual either living or dead.

Aim:
To develop and evaluate the efficacy of coding system for ceramic restorations for retrieving the identity of individual in forensic dentistry.

Technique:
IPS E-max Press ingots, Glaze & Stain Liquid for E-max, Thermal transfer ink ribbon-YS-350T, Heat resistant QR code strips-HP-CBR X1617. This study focused on developing of the code to be used for ceramic restoration. A QR code (data matrix) was developed to be incorporated in the all ceramic restorations. A total of fifty samples were used to incorporate the code which were then subjected to readability by the scanner/ android mobile phone.

Conclusion:
AQR (data matrix) was developed of size 3.75 mm which was readable after incorporation in the all ceramic restoration.
Effect of Concentrated Acids on Teeth
Authors: Kadashett Vidya , Shivakumar K. M. , Baad Rajendra , Vibhute Nupura , Belgaumi Uzma , Bommanavar Sushma , Kamate Wasim 
Published: August 2024

Background:
The proceedings of destroying the body of human by putting in acid or some other injurious materials in order to prevent any individual identification is drawing a great deal of importance in forensic field. The idea of such crime is to destroy any physical evidence of cause of death, time interval of death to body identification, and victim identification. Teeth are also good reservoirs for the identification of individuals by morphological as well as identification by mitochondrial DNA extraction.

Aims and Objectives:
To assess the morphological changes and duration of dissolution of teeth from different acids.

Materials and Methods:
Concentrated hydrochloric acid (HCl), nitric acid (HNO3), and sulfuric acid were employed for tooth.

Results:
Results showed that compared to sulfuric acid, HCl and HNO3 have more destructive capacity.

Conclusion:
Sulfuric acid, HNO3, and HCl criminals may be used to destroy the person identification; still, the individuals can be identified using teeth because it is the strongest structure of the human body and can preserve some structures even after exposure to the concentrated acids.