bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uric acid and risk of periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention
Authors: Verdoia Monica , Schaffer Alon , Barbieri Lucia , Di Giovine Gabriella , Marino Paolo , De Luca Giuseppe ,   on behalf of the Novara Atherosclerosis Study Group (NAS)
Published: December 2013

AbstractBackgroundPeriprocedural myocardial infarction still occurs in patients undergoing percutaneous coronary intervention. However, very little is known about the role of biomarkers possibly predicting this complication. Serum uric acid has been associated with enhanced inflammatory status, higher thrombotic risk and poorer outcome after percutaneous coronary intervention. We therefore, evaluated the association between uric acid levels and periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention.MethodsWe evaluated 1272 consecutive patients undergoing percutaneous coronary intervention. We measured myonecrosis biomarkers at intervals from 8 to 48 h after percutaneous coronary intervention. Periprocedural myonecrosis was defined as a troponin I increase by 3 times the upper limit normal (ULN) or by 50% of an elevated baseline value and periprocedural myocardial infarction as creatine kinase‐Myocardial Band increase by 3 times the ULN or 50% of baseline.ResultsPatients were divided according to tertile values of uric acid (<5.40, ≥6.70 mg/dL). Serum uric acid was related to age, male gender, hypertension, smoking, renal failure (p < 0.001), previous coronary artery bypass grafts (p = 0.05), therapy with ACE inhibitors (p = 0.001) and diuretics (p < 0.001), glycaemia (p = 0.001), creatinine (p < 0.001), haemoglobin (p = 0.002) and white blood cells (p = 0.02). Serum uric acid was inversely related to type C lesions (p = 0.03) and coronary thrombus (p = 0.02). SUA did not affect the risk of periprocedural myocardial infarction (p = 0.29; adjusted odds ratio = 1.11[0.93–1.32], p = 0.26) or periprocedural myonecrosis (p = 0.97; adjusted odds ratio = 0.99[0.86–1.14], p = 0.89). Results were confirmed at subgroup analyses of higher‐risk subsets of patients.ConclusionThis is the first large study showing that serum uric acid is not associated with an increase in the risk of periprocedural myocardial infarction in patients undergoing percutaneous coronary revascularization. Copyright © 2013 John Wiley & Sons, Ltd.
Renin angiotensin system inhibitors may attenuate low LDL cholesterol‐related cancer risk in type 2 diabetes
Authors: Yang Xilin , Ma Ronald C. W. , So Wing Yee , Wang Ying , Kong Alice P. S. , Ozaki Risa , Xu Gang , Chan Juliana C. N. 
Published: December 2013

AbstractBackgroundIn type 2 diabetes (T2D), copresence of low‐density lipoprotein cholesterol (LDL‐C) <2.8 mmol/L with triglyceride <1.7 mmol/L or with albuminuria synergistically increased cancer risk. We tested whether use of renin angiotensin system inhibitors attenuated the increased cancer risk associated with these two risk subphenotypes.MethodsA prospective cohort of 4307 patients with T2D enrolled from December 1996 to January 2005 was analysed using a new user cohort design. Cox model analysis was used to obtain hazard ratios and 95% confidence intervals. The study measured additive interactions between nonuse of renin angiotensin system inhibitors and low LDL‐C plus low triglyceride or albuminuria for the risk of cancer. A positive interaction suggests a specific drug effect on the low LDL‐C‐related cancer risk.ResultsDuring 18 769 person years of follow‐up (median follow‐up years: 4.44), 4.48% (n = 193) of patients developed cancer. Use of renin angiotensin system inhibitors was associated with reduced cancer risk among patients with copresence of low LDL‐C plus low triglyceride or low LDL‐C plus albuminuria but not in patients without these subphenotypes. In multivariable analysis, renin angiotensin system inhibitor usage attenuated the hazard ratio of copresence of low LDL‐C plus low triglyceride versus lack of this subphenotype for cancer from 2.08 (95% CI: 1.25–3.47) to 1.13 (0.61–2.11) with significant additive interaction (p = 0.0225). Similarly, RAS inhibitor usage attenuated the hazard ratio of copresence of low LDL‐C plus albuminuria versus lack of this subphenotype for cancer from 1.99 (95% CI: 1.12–3.56) to 0.82 (0.43–1.54) with significant additive interaction (p = 0.0009).ConclusionIn T2D, renin angiotensin system inhibitor usage may specifically attenuate the low LDL‐C‐related cancer risk. Copyright © 2013 John Wiley & Sons, Ltd.
Lithiated MoO2 Nanorods with Greatly Improved Electrochemical Performance for Lithium Ion Batteries
Authors: Zhang Xia , Zeng Xianzhong , Yang Min , Qi Yanxing 
Published: December 2013

AbstractHighly uniform MoO2 nanorods were successfully synthesized by a facile hydrothermal method, and the resultant sample was easily lithiated by subsequent treatment with LiCl solution. After lithiation, the MoO2 nanorods possessed a similar crystalline structure to the unlithiated sample. At a current density of 20 mA g–1, the lithiated specimen with better coulombic efficiency displayed a preferable cycling performance and exhibited excellent reversible charge‐discharge capacity, while the unlithiated MoO2 exhibited more irreversible behavior. This conclusion was also supported by δ, the fraction loss per cycle, which was 2.5 % and 5.2 % for the lithiated and unlithiated MoO2, respectively. Finally, the XRD patterns for the lithitated and unlithiated MoO2 showed that the former retained better crystallization than the latter after a 15‐cycle charge‐discharge process.
Synthesis, Structure, and Reactivity of [Cu(phen)2]ClO2: Aerobic Oxidation of Cl– to ClO2– at Room Temperature
Authors: Hossain Md. Munkir , Tseng Mei‐Chun , Lee Chi‐Rung , Shyu Shin‐Guang 
Published: December 2013

AbstractAn unusual 4e– oxidation of Cl– into ClO2– occurred during the reaction between CuCl and phenanthroline (phen) in air to form a [Cu(phen)2]ClO2 complex, which is capable of oxidizing catechol into the highly substituted pentenone derivative methyl 1‐hydroxy‐2‐oxo‐4,5,5‐trimethoxycyclopent‐3‐ene‐1‐carboxylate through contraction of the aromatic ring by extradiol C–C bond cleavage concomitant with the further formation of a C–C bond.
Alkylation Effects in Lanthanide Complexes Involving Tetrathiafulvalene Chromophores: Experimental and Theoretical Correlation between Magnetism and Near‐Infrared Emission
Authors: Cosquer Goulven , Pointillart Fabrice , Jung Julie , Le Guennic Boris , Golhen Stéphane , Cador Olivier , Guyot Yannick , Brenier Alain , Maury Olivier , Ouahab Lahcène 
Published: December 2013

AbstractMononuclear complexes with the formula [Ln(hfac)3(L1)] and [Ln(hfac)3(L2)] with hfac– = 1,1,1,5,5,5‐hexafluoroacetylacetonate, L1 = 2‐{4,5‐[4,5‐bis(propylthio)tetrathiafulvalenyl]‐1H‐benzimidazol‐2‐yl}pyridine and L2 = 2‐{1‐methylpyridyl‐4,5‐[4,5‐bis(propylthio)tetrathiafulvalenyl]‐1H‐benzimidazol‐2‐yl}pyridine are reported for Ln = YIII, ErIII and YbIII. The X‐ray structures reveal that the Ln(hfac)3 moieties are coordinated to the bidentate 1‐(2‐pyridylmethyl)benzimidazole acceptor. The coordination polyhedron is described as a more or less distorted triangular dodecahedron prism (D2d symmetry), depending on the degree of alkylation of the ligand. The influence of this distortion on the magnetic and photophysical properties is determined by the fit of the static magnetic measurements and luminescence spectra. Irradiation of the lowest‐energy intraligand charge transfer (ILCTs) bands (21740 cm–1) induces the metal‐centred 4I13/2 → 4I15/2 and 2F5/2 → 2F7/2 luminescence for the ErIII and YbIII complexes, respectively. The alkylation enhances both the intensity and lifetime of the YbIII luminescence. The ErIII luminescence can be sensitised by the antenna effect, whereas the YbIII luminescence could involve a photoinduced electron transfer (PET). Finally, the evolution of the YbIII luminescence spectra shape due to the alkylation is directly correlated to the energy splitting of the MJ states that stem from the 2F7/2 multiplet ground state. Ab initio calculations give evidence of the nature of the MJ ground state as well as the orientation of the associated magnetic anisotropy axis (i.e., the one that lies along the less electronegative direction). The key role of the imidazole proton of L2 is highlighted. The calculated energy splitting of the 2F5/2 multiplet state perfectly matches the emission lines.
Combining single‐use stirred bioreactor with standard cross‐flow technology in biphasic protein production processes at pilot scale
Authors: Blaschczok Katharina , Löffelholz Christian , Eibl Regine , Eibl Dieter 
Published: December 2013

The increasing implementation of single‐use bioreactors arrived hand‐in‐hand with the development of new technologies contributing to increased productivity, process flexibility, and additional savings in time and costs. As a result, hollow fiber technology has recently gained renewed interest in upstream processing. Using a Chinese hamster ovary cell line in a biphasic protein production process with chemically defined minimal culture media, we combined Sartorius Stedim's BIOSTAT STR 50 L with GE Healthcare Life Sciences’ reusable Hollow Fiber Cartridge CFP‐6‐D‐55A. After a 3‐day feeding growth phase, secretion of the model protein secreted alkaline phosphatase (SEAP) was introduced by replacing the growth medium with production medium using cross‐flow filtration. The process was then continued and harvested as a batch with temperature shift. High cell densities exceeding 1 × 107 cells mL−1 were achieved 5 days post inoculation and maximum secreted alkaline phosphatase activities of 24 U mL−1 11 days post inoculation. Our results showed that a further decrease in processing time is possible by reducing the number of diafiltration steps from three to two.
Semiparametric Tests for Identifying Differentially Methylated Loci With Case–Control Designs Using Illumina Arrays
Authors: Chen Yong , Ning Yang , Hong Chuan , Wang Shuang 
Published: December 2013

ABSTRACTDNA methylation plays an important role in the development of many types of cancer. Identifying differentially methylated loci between cancer and normal patients is one of the central tasks to understand the contributions of the methylation process on cancer development. Through investigation of the methylation measurements generated by the Illumina methylation arrays, we notice that the methylation measurements of the cancer and normal groups could differ not only in means but also in variances. Therefore, we propose a generalized exponential tilt model to capture the differences in both means and variances between the cancer and normal groups. We derive the semiparametric tests to obtain model robustness. Through simulation studies, we demonstrate the feasibility of the proposed tests and a much improved power of the proposed tests than that of thet‐test and the regression‐based tests when the cancer and normal groups are different in variances only or in both means and variances. Hence the proposed tests can serve as useful complements to the standard tests that only test differences in means. We also illustrate the proposed methods by applying to a real methylation data from a recent study on ovarian cancer where the proposed methods identified additional methylation loci that were missed by the existing method.
Validation of the Perceived Stress Scale in a community sample of older adults
Authors: Ezzati Ali , Jiang Julie , Katz Mindy J. , Sliwinski Martin J. , Zimmerman Molly E. , Lipton Richard B. 
Published: December 2013

BackgroundThree versions of Perceived Stress Scale (PSS‐14, PSS‐10, and PSS‐4) are among the most widely used measures of stress. The aim of the current study was to validate this instrument in a sample of nondemented older adults to facilitate studies of the impact of stress on health.MethodsSeven hundred sixty‐eight nondemented adults over the age of 70 years completed the PSS‐14 questionnaire and other neuropsychological tests. Exploratory factor analysis was used to determine the underlying factor structure of all PSS versions, and confirmatory factor analysis was used to test the construct validity of factors. The internal consistency reliability of the scales was assessed using Cronbach's alpha, and concurrent validity was evaluated by examining PSS relation with age, gender, depression, anxiety, and Positive Affect and Negative Affect Schedule.ResultsA two‐factor model was the optimal fit for the 14‐item and 10‐item versions of PSS. For PSS‐14, all items' loadings exceeded 0.4 for one of the two factors except item 12. Therefore, we studied a 13‐item version of PSS and 10‐item and 4‐item subsets representing PSS‐10 and PSS‐4. Internal consistency coefficients were satisfactory for the full scale of PSS‐13 and PSS‐10 but not for PSS‐4. Women reported higher levels of stress than men. Higher levels of total PSS scores showed association with higher levels of depression, anxiety, and negative affect, and lower level of positive affect.ConclusionsThe 13‐item and 10‐item versions of PSS may be used to understand the experience of stress among older adults. Copyright © 2013 John Wiley & Sons, Ltd.
A meta‐analysis of inositol for depression and anxiety disorders
Authors: Mukai Tomohiko , Kishi Taro , Matsuda Yuki , Iwata Nakao 
Published: December 2013

ObjectiveThis study is a meta‐analysis of inositol as a treatment for depression and anxiety disorders.MethodsPubMed, Cochrane Library database, and PsycINFO were searched up to 14 August 2013. A systematic review and meta‐analysis of double‐blind, randomized, placebo‐controlled trials (RCTs) were conducted comparing inositol for depressed or anxiety disorder patients.ResultsSeven RCTs in depression (two bipolar depression studies, one bipolar depression and major depressive disorder (MDD) study, two MDD studies, and two premenstrual dysphoric disorder (PMDD) studies) (n = 242) were identified. Four RCTs in anxiety disorders (two obsessive–compulsive disorder studies, one panic disorder study, and one posttraumatic stress disorder study) (n = 70) were also identified. There were no statistically significant effects of inositol on depressive, anxiety, and obsessive–compulsive symptoms and discontinuation (all‐cause, side effects, and worsening psychiatric symptoms). However, inositol had marginally more responders in depression than placebo (p = 0.06), and inositol showed a trend towards superior efficacy for depressive symptoms in patients with PMDD (p = 0.07). Inositol marginally caused gastrointestinal upset compared with placebo (p = 0.06).ConclusionsOur results suggest that inositol may be beneficial for depressed patients, especially those with PMDD. The main limitation of this report is that a small number of studies were included in this meta‐analysis. Copyright © 2013 John Wiley & Sons, Ltd.
ANTECEDENT MOISTURE CONDITION (SCS) FREQUENCY ASSESSMENT: A CASE STUDY IN SOUTHERN ITALY
Authors: de Paola Francesco , Ranucci Antonio , Feo Angelo 
Published: December 2013

ABSTRACTThis paper reports on a procedure used to define the joint probability distribution of two hydrological variables describing a meteoric event: the maximum intensity of the rain and the accumulation in the antecedent five days. The main goal is to define the frequency of occurrence of the three antecedent moisture condition classes of the SCS‐CN method connected to extreme intensity rain events, with reference to a very precise data set containing records with aggregation time of 10 min. In order to define the relation between the hydrological variables, the marginal distribution of the two variables was first identified and afterwards the global dependency structure was studied through the copula function.Afterwards, according to data collected from rain gauge stations located in the Campania region, in southern Italy, and selecting peak‐intensity rain events higher than 20 mm h–1, the evidence was that the AMCI class is the most frequent, rather than the AMCIII class (the frequency of which is never above 26% in the vegetal dormant season and 12% in the vegetal growing season).Such results lead to the conclusion that using the AMCIII class in design calculation, mainly in dry areas (like southern Italian regions), is not particularly suitable, while the use of AMCII is more advisable. Copyright © 2013 John Wiley & Sons, Ltd.
A STOCHASTIC INDEX METHOD FOR CALCULATING ANNUAL FLOW DURATION CURVES IN INTERMITTENT RIVERS
Authors: Rianna Maura , Efstratiadis Andreas , Russo Fabio , Napolitano Francesco , Koutsoyiannis Demetris 
Published: December 2013

ABSTRACTFlow duration curves are useful tools to estimate available surface water resources, at the basin scale. These represent the percentage of time during which discharge values are exceeded, irrespective of their temporal sequence. Annual flow duration curves are useful tools for evaluating all flow quantiles of a river and their confidence intervals, by removing the effects of variability from year to year. However, these tools fail to represent the hydrological regime of ephemeral rivers, since they cannot account for zero flows. In this work we propose a technique for calculating annual flow duration curves and their standard deviation in the case of intermittent rivers. In particular, we propose a generalization of the stochastic index method, in which we use the concept of total probability and order statistics. The method is proposed to determine the conditional distribution of positive flows, for given probability of dryness, and is implemented on three catchments in Italy and Greece, with low (<5%) and high (>40%) frequency of zero flows, respectively. Copyright © 2013 John Wiley & Sons, Ltd.
FLOOD HAZARD ASSESSMENT VIA THRESHOLD BINARY CLASSIFIERS: CASE STUDY OF THE TANARO RIVER BASIN
Authors: Degiorgis Massimiliano , Gnecco Giorgio , Gorni Silvia , Roth Giorgio , Sanguineti Marcello , Taramasso Angela Celeste 
Published: December 2013

ABSTRACTThis contribution deals with the identification of flood hazards at the catchment scale. The aim is to distinguish flood‐exposed areas from marginal risk ones, and to extend available information on flood hazards to cover the whole catchment. Threshold binary classifiers based on six selected quantitative morphological features, derived from data stored in digital elevation models (DEMs), are used to investigate the relationships between morphology and the flooding hazard, as described in flood hazard maps. Results show that threshold binary classifier techniques should be taken into account when one is interested in an initial low‐cost detection of flood‐exposed areas. This may be needed, for example, in applications related to the insurance market, in which one is interested in estimating the flood hazard of specific areas for which limited information is available, or whenever a first flood hazard delineation is required to further address detailed investigations for flood mapping purposes. The method described in the paper has been tested on the basin of the Tanaro River. Results present a high degree of accuracy: indeed, the best classifier correctly identifies about 91% of flood‐exposed areas, whereas the percentage of the areas exposed to marginal risk that are incorrectly classified as flood‐exposed areas is about 16%. Copyright © 2013 John Wiley & Sons, Ltd.
EVALUATION OF RAINFALL THRESHOLDS THROUGH ENTROPY: INFLUENCE OF BIVARIATE DISTRIBUTION SELECTION
Authors: Ridolfi Elena , Montesarchio Valeria , Rianna Maura , Sebastianelli Stefano , Russo Fabio , Napolitano Francesco 
Published: December 2013

ABSTRACTFloods cause severe damage worldwide in terms of human injury and have severe economic consequences, causing landslides, road accidents and inundation of agricultural areas. Non‐structural flood protection strategies offer the possibility to protect the land, preventing flood event effects. In particular, early warning systems can inform of flood occurrences. These systems can be based on the evaluation of a rainfall threshold value that is the rainfall amount that determines a critical discharge in a given river cross‐section. The alert is issued if the observed or forecast rainfall equals the threshold value without the support of online real‐time rainfall–runoff forecasting systems.The critical rainfall threshold values are evaluated by a probabilistic methodology, considering the joint cumulative distribution of cumulated rainfall and the corresponding peak discharge, for different durations. To estimate the joint distributions two approaches are considered: the meta‐Gaussian and the copula functions.The rainfall threshold values are estimated for the Mignone River basin (Italy). Results show that both joint distribution functions perform well in estimating the rainfall threshold values, as found from reliability analysis. In particular, the copula‐based approach leads to issuing the alert in advance. Copyright © 2013 John Wiley & Sons, Ltd.
Development of fore‐ and hindlimb muscles in GFP‐transgenic axolotls: Morphogenesis, the tetrapod bauplan, and new insights on the Forelimb‐Hindlimb Enigma
Authors: Diogo Rui , Tanaka Elly M. 
Published: December 2013

ABSTRACTThe axolotl is becoming one of the most used model organisms in developmental and regenerative studies but no publication has described in detail the development of its forelimb and hindlimb muscles. We describe and illustrate the ontogeny of these muscles in transgenic axolotls that express GFP in muscle fibers and discuss our results and data previously obtained by us and by other authors about limb regeneration in axolotls and ontogeny in frogs and other tetrapods. Our observations and comparisons: (1) demonstrate radio‐ulnar and ventro‐dorsal morphogenetic gradients in the order of axolotl forelimb muscle formation and differentiation, while in axolotl hindlimb ontogeny there are only proximo‐distal and tibio‐fibular gradients; some of the axolotl gradients are therefore different from the ulno‐radial/fibulo‐tibial fore‐ and hindlimb and the dorso‐ventral hindimb ontogenetic morphogenetic gradients seen in frogs and amniotes such as chickens; (2) provide a potential explanation for the usual presence, in both limbs of taxa from all major tetrapod groups, of more radial/tibial muscles than ulnar/fibular muscles; (3) support the “in‐out” developmental mechanism of appendicular muscle formation; (4) offer new insights about the ancestral Bauplan of tetrapod limbs, including the striking similarity of the zeugopodial (forearm/leg) and autopodial (hand/foot) muscles of the two limbs and the ventro‐dorsal symmetry of the zeugopodial muscles of a same limb; and (5) provide further evidence to corroborate the hypothesis that these similarities are due to derived homoplastic events that occurred during the fins‐limbs transition and not due to forelimb–hindlimb serial homology. J. Exp. Zool. (Mol. Dev. Evol.) 322B: 106–127, 2014. © 2013 Wiley Periodicals, Inc.