bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipase‐Catalyzed Kinetic Resolution of (±)‐1‐(2‐Furyl) Ethanol in Nonaqueous Media
Authors: Devendran Saravanan , Yadav Ganapati D. 
Published: April 2014

ABSTRACTS‐1‐(2‐Furyl) ethanol serves as an important chiral building block for the preparation of various natural products, fine chemicals, and is widely used in the chemical and pharmaceutical industries. In this work, lipase‐catalyzed kinetic resolution of (R/S)‐1‐(2‐furyl) ethanol using different acyl donors was investigated. Vinyl esters are good acyl donors vis‐à‐vis alkyl esters for kinetic resolution. Among them, vinyl acetate was found to be the best acyl donor. Different immobilized lipases such as Rhizomucor miehei lipase, Thermomyces lanuginosus lipase, and Candida antarctica lipase B were evaluated for this reaction, among which C. antarctica lipase B, immobilized on acrylic resin (Novozym 435), was found to be the best catalyst in n‐heptane as solvent. The effect of various parameters was studied in a systematic manner. Maximum conversion of 47% and enantiomeric excess of the substrate (ees) of 89% were obtained in 2 h using 5 mg of enzyme loading with an equimolar ratio of alcohol to vinyl acetate at 60°C at a speed of 300 rpm in a batch reactor. From the analysis of progress curve and initial rate data, it was concluded that the reaction followed the ordered bi–bi mechanism with dead‐end ester inhibition. Kinetic parameters were obtained by using nonlinear regression. This process is more economical, green, and easily scalable than the chemical processes. Chirality 26:286–292, 2014. © 2014 Wiley Periodicals, Inc.
Time‐Based Detection of Single Particles in Sieve Classification Using Radio‐Frequency Identification
Authors: Kaufeld Sebastian , Feil Alexander , Pretz Thomas 
Published: April 2014

AbstractIn der Siebklassierung wird eine hohe Trennschärfe angestrebt. Zielsetzung dieser Arbeit war der Aufbau eines Versuchsstands, mit dem das Verweilzeitverhalten definierter Einzelkornfraktionen beim Siebvorgang kontinuierlich erfasst werden kann. Transponder wurden an geometrisch definierten Prüfkörpern fixiert und deren Austragszeit mittels Radiofrequenz‐Identifikation (RFID) erfasst. Die Ergebnisse zeigen die grundsätzliche Eignung der RFID‐Technologie für diese Aufgabe. Beschränkungen stellen hohe Prüfkörper‐Austragsströme dar, die u. a. zu verringerten Erfassungsraten führen.
Treatment with FLT3 inhibitor in patients with FLT3‐mutated acute myeloid leukemia is associated with development of secondary FLT3–tyrosine kinase domain mutations
Authors: Alvarado Yesid , Kantarjian Hagop M. , Luthra Rajyalakshmi , Ravandi Farhad , Borthakur Gautam , Garcia‐Manero Guillermo , Konopleva Marina , Estrov Zeev , Andreeff Michael , Cortes Jorge E. 
Published: April 2014

BACKGROUNDFLT3–internal tandem duplication (ITD) mutations are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 inhibitors have shown clinical activity in AML with FLT3‐ITD, but responses are usually short‐lived.METHODSThis study examined 69 FLT3‐mutated patients with AML, who were treated with different FLT3 inhibitors to analyze emergence of new mutations.RESULTSAt baseline, 87% of patients had an ITD mutation, 7% had a D835/I836 mutation, and 6% had combined ITD and D835/I836 mutations. Responses occurred in 32% of patients, all with FLT3‐ITD; none of the patients with D835/I836 or ITD+D835/I836 responded. Mutational assessment at the time of FLT3 inhibitor discontinuation showed that 68% of patients were unchanged, 10% had become undetectable, and 22% of patients progressed from a single ITD to have combined ITD+D835/I836 mutations. In those patients with unchanged FLT3 mutation at progression, the median survival was 5 months, whereas in those with undetectable and with combined ITD+D835/I836 mutations, the median survival was 7 months, respectively.CONCLUSIONSThese data confirm in vitro observations that a secondary tyrosine kinase domain mutation may arise after the use of FLT3 inhibitors in patients with single FLT3‐ITD mutated AML, a phenomenon that is associated with resistance and a poor prognosis. Cancer 2014;120:2142–2149. © 2014 American Cancer Society.
Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations
Authors: Lee Youngjoo , Lee Geon Kook , Lee Yeon‐Su , Zhang Wenji , Hwang Jung‐Ah , Nam Byung‐Ho , Kim Seok Hyun , Kim Joo‐Hang , Yun Tak , Han Ji‐Youn , Kim Heung Tae , Lee Jin Soo 
Published: April 2014

BACKGROUNDEpidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors (EGFR‐TKIs) in patients with EGFR‐mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. The objective of the current study was to evaluate whether the clinical outcomes are affected by the percentage of preexisting T790M mutations within a tumor.METHODSPretreatment tissues were collected from 124 patients with advanced non‐small cell lung cancer with sensitizing EGFR mutations that were detected by direct sequencing. Genotyping for EGFR T790M mutation was further performed using matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry. Patients who were positive for the T790M mutation were divided to 2 subgroups according to T790M mutant signal frequency.RESULTSThe T790M mutation was found in 31 patients (25.0%). The T790M mutation frequency at which the risk of disease progression after therapy with EGFR‐TKIs begins to increase was estimated to be 3.2%. The patients with T790M‐positive tumors had a shorter time to disease progression after treatment with EGFR‐TKIs (median, 6.3 months vs 11.5 months; P < .001) and overall survival (median, 16.1 months vs 26.5 months; P = .065) compared with those with T790M‐negative tumors. Among the T790M‐positive patients, the patients with high T790M frequency (9 patients) were found to have a shorter time to disease progression (median, 2.4 months vs 6.7 months; P = .009) and overall survival (median, 9.1 months vs 18.7 months; P = .018) compared with those with low T790M frequency (22 patients).CONCLUSIONSA preexisting EGFR T790M mutation was noted in 25% of patients with EGFR‐mutant lung cancer. Patients with a high T790M mutation frequency had worse clinical outcomes to EGFR‐TKIs than patients with a low T790M mutation frequency. Cancer 2014;120:2090–2098. © 2014 American Cancer Society.
Sodium‐Ion Battery based on an Electrochemically Converted NaFePO4 Cathode and Nanostructured Tin–Carbon Anode
Authors: Hasa Ivana , Hassoun Jusef , Sun Yang‐Kook , Scrosati Bruno 
Published: April 2014

AbstractWe report a new sodium‐ion battery formed by coupling a NaFePO4 cathode and a nanocomposite tin–carbon (Sn–C) sodium‐alloying anode. The NaFePO4 cathode is obtained by Li–Na conversion of a LiFePO4 cathode directly in the full cell employing the Sn–C anode and a sodium‐ion electrolyte. The results show that the unique approach adopted here is capable of successfully and efficiently converting LiFePO4 into NaFePO4 in a sodium‐ion battery operating at a voltage of 3 V, with a maximum reversible capacity of 150 mAh g−1, high reversibility, and high rate capability.
In Situ Growth of Noble‐Metal Nanoparticles on Cu2O Nanocubes for Surface‐Enhanced Raman Scattering Detection
Authors: Wang Jie , Cui Fangling , Chu Sibin , Jin Xiaoquan , Pu Jun , Wang Zhenghua 
Published: April 2014

AbstractInvited for this month’s cover is the group of Prof. Zhenghua Wang from Anhui Normal University, China. The cover picture shows the synthesis of Cu2O/noble metal nanocomposites. The as‐obtained nanocomposites are applied as SERS substrates with high sensitivity and good reproducibility, which can be used for the detection of food contaminants. Read the full text of the article at 10.1002/cplu.201400028
Surface Functionalization for Synergistic Catalysis: Silica–Alumina‐Supported Cationic Indium and Organic Base for Cyanoethoxycarbonylation
Authors: Motokura Ken , Ito Yasuhiro , Noda Hiroto , Miyaji Akimitsu , Yamaguchi Sho , Baba Toshihide 
Published: April 2014

AbstractA silica–alumina (SiO2–Al2O3) surface possessing both In3+ cations and an amine base has been prepared. Surface‐functionalized SiO2–Al2O3 was characterized by solid‐state 29Si MAS, 13C CP/MAS, and 27Al 2D MQ/MAS NMR spectroscopy; X‐ray photoelectron spectroscopy; and elemental analysis. The bifunctional surface demonstrates synergistic catalysis for cyanoethoxycarbonylation of aldehyde.
Psychometric characteristics of the night eating questionnaire in a middle east population
Authors: Elsadek Adel M. , Hamid Mohamed S. , Allison Kelly C. 
Published: April 2014

ABSTRACTObjectiveTo translate and validate the Night Eating Questionnaire (NEQ) into Arabic and to describe the distribution of night eating in an Egyptian sample.MethodThe NEQ was translated into Arabic and administered to 420 university students in Cairo, Egypt. Reliability, validity, and clinical cut‐scores were generated for the Arabic NEQ. Distribution and demographic information were examined.ResultsCronbach's alpha for the Arabic NEQ was 0.54. A first order confirmatory factor analysis yielded five factors: 1: Nocturnal Ingestions, Factor 2: Evening Hyperphagia, Factor 3: Morning Anorexia, Factor 4: Insomnia, and Factor 5: Mood. A total NEQ score of 26 was determined to be very high after T‐score transformation. Of the students, 4.8% scored above this cut score, and no differences for total NEQ score were found for demographic variables.DiscussionThe Arabic NEQ generated a lower internal consistency score as compared to previous translations, but a similar factor structure. A cut score of 26 is similar to that determined significant for screening purposes in the original English version, and the proportion of those scoring above it is also similar to those of several international community samples. More research is needed to characterize night eating syndrome, its symptoms, and clinical impact in the Arabic culture. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:660–665)
Regioselective Biomimetic Oxidative Cyclization Strategy for the Synthesis of Aryldihydronaphthalene Lignans
Authors: Li Wenling , Liu Hao , Xu Jingyan , Zang Peng , Liu Qian , Li Wenbo 
Published: April 2014

AbstractA regioselective biomimetic oxidative cyclization strategy for the construction of aryldihydronaphthalene skeletons has been developed as an efficient synthetic approach to the preparation of natural 8‐8‐cyclic diferulic acid and canabisin D. The oxidative coupling of ethyl 5‐tert‐butylferulate catalyzed by different oxidants yielded tetrahydrofuran or dibenzylidenesuccinate‐type 8‐8‐coupling products, which were subsequently subjected to acid‐catalyzed cyclization to produce several isomeric trans‐aryldihydronaphthalenes. The reaction mechanisms for all the cyclization reactions have also been proposed.
Catalyst‐Free One‐Pot Tandem Reduction of Oxo and Ene/Yne Functionalities by Hydrazine: Synthesis of Substituted Oxindoles from Isatins
Authors: Jha Mukund , Shelke Ganesh M. , Kumar Anil 
Published: April 2014

AbstractAn unprecedented one‐pot tandem reduction of oxo and ene/yne functionalities of substituted isatins is disclosed for the synthesis of oxindole derivatives in excellent yields. The reaction is simply performed by treating N‐(2‐alkenyl)/propargylisatins with an excess amount of hydrazine hydrate (25 %) under catalyst‐free refluxing conditions. The reduction process appears to be quite unique and proceeds quite efficiently without the aid of any catalyst at ambient pressure.
Heritability and lifestyle factors in chronic low back pain: Results of the Australian Twin Low Back Pain Study (The AUTBACK study)
Authors: Junqueira D.R.G. , Ferreira M.L. , Refshauge K. , Maher C.G. , Hopper J.L. , Hancock M. , Carvalho M.G. , Ferreira P.H. 
Published: April 2014

AbstractBackgroundHeritability and population‐specific lifestyle factors are considered to significantly contribute to chronic low back pain (LBP), but traditional population studies fail to (1) adjust for genetics; and (2) use standard and validated definitions for LBP and for lifestyle factors.MethodsUsing a classical and a co‐twin control study design and validated definitions for chronic LBP and lifestyle variables, we explored the relative contribution of genetics and environment on the prevalence of chronic LBP in a sample of adult Australian twins.ResultsData from 105 twin pairs showed that the prevalence of chronic LBP is significantly determined by genetic factors (heritability = 32%). Additionally, monozygotic twins were five times more likely to have chronic LBP than dizygotic twins when one of the siblings of the pair was affected. In a case‐control analysis (n = 38 twin pairs), an exploratory analysis showed higher prevalence of chronic LBP associated with light walking exercises and vigorous gardening or heavy work around the house. Daily time spent in sitting was also positively associated with chronic LBP, but not moderate physical activities such as jogging, cycling and gentle swimming. In the final multivariate model, only time spent in vigorous gardening or heavy work around the house remained associated with chronic LBP (odds ratio 6.5; 95% confidence interval 1.47–28.8).ConclusionsThe type, frequency and duration of physical activity may be important to understand risk factors for chronic LBP. The causation path between chronic LBP and people's engagement in activities involving frequent bending and twisting such as gardening and housework should be further investigated.
Pain reactivity in preterm neonates: examining the sex differences
Authors: Valeri B.O. , Gaspardo C.M. , Martinez F.E. , Linhares M.B.M. 
Published: April 2014

AbstractBackgroundEarly and repeated experiences of pain may have long‐term effects on vulnerable newborns hospitalized in the Neonatal Intensive Care Unit (NICU), and neonatal pain responses may be affected by a variety of factors that neonates encounter. We tested the hypothesis that male preterm neonates exhibited greater pain sensitivity than females by assessing biobehavioural pain reactivity and recovery patterns to painful procedure.MethodsFifty‐three infants born preterm and low birthweight who were admitted to NICU were observed during five phases (baseline, antisepsis, puncture, recovery‐dressing and recovery‐resting). Behavioural pain reactivity was measured using the Neonatal Facial Coding System (NFCS) and the Sleep–Wake States Scale (SWS). The heart rate (HR) was continuously recorded. All measures were assessed based on scores and magnitude of responses.ResultsWe found that male and female preterm neonates had similar patterns of behavioural pain reactivity and recovery; there were no statistical differences between groups in NFCS and SWS scores. However, male preterm infants presented higher HR immediately in the first minute of the puncture phase and also higher change in maximum HR between the baseline and puncture phases, than female preterm infants.ConclusionAlthough we found that male infants showed higher physiological reactivity to painful stimulus in some HR parameters than female infants, the evidences were not sufficient to confirm the influence of sex on biobehavioural response to pain in vulnerable neonates.
Pain threshold and sleep quality in women with endometriosis
Authors: Nunes F.R. , Ferreira J.M. , Bahamondes L. 
Published: April 2014

AbstractBackgroundPain is a common complaint in women with endometriosis and can be influenced by many variables, including sleep disorders; however, no data are available on the sleep quality of women with endometriosis or on the correlation between sleep quality and pain.MethodsThe 510 volunteers included in this study were divided into two groups: 257 women with a laparoscopic and histopathological diagnosis of endometriosis and 253 women with no history of endometriosis and no endometriosis‐related symptoms. The volunteers answered two questionnaires: the Post‐Sleep Inventory to evaluate sleep quality and the International Physical Activity Questionnaire to assess their level of physical activity. Pain was evaluated using a visual analogue scale (VAS) and women were also submitted to a physical examination, during which their pain threshold was assessed at 20 different body sites.ResultsSleep quality was significantly poorer in women with endometriosis compared to women without the disease. The pain threshold was significantly lower in the greater trochanter and abdomen in women with endometriosis when compared to women without the disease; however, there was no difference in VAS pain score between the groups. The higher the VAS pain score, the lower the Post‐Sleep Inventory score. Additionally, there was a significant positive correlation between the pain threshold at some body sites and sleep quality.ConclusionsSleep quality was poorer and the pain threshold at certain body sites was lower in the group of women with endometriosis.
Electrochemical Analysis of Acrylamide Using Screen‐Printed Carboxylated Single‐Walled Carbon Nanotube Electrodes
Authors: González‐Fuentes Fanny Jaqueline , Manríquez J. , Godínez Luis A. , Escarpa Alberto , Mendoza Sandra 
Published: April 2014

AbstractAcrylamide (AA) was electrochemically detected and quantified by means of its voltammetric response on carboxylic modified Single‐Walled Carbon Nanotube Screen Printed Electrodes (COOH‐SWCNT‐SPEs). The electroreduction signal of AA was proportional to AA concentration at low values (below 300 µM) and the observed sensitivity was explained in terms of AA adsorption on the COOH‐SWCNT‐SPEs that was demonstrated using the electrochemical response of [Fe(CN)6]3− and [Fe(CN)6]4− and Raman spectroscopy experiments. In order to test the suggested analytic approach (LOD of 0.03 µM, LOQ of 0.04 µM), detection and quantification of AA in fried potatoes was carried out using the proposed electrochemical method and HPLC. Both techniques showed similar contents of AA.
Voltammetry of Ferrocenated Gold Nanoparticles on a Nanometer‐Sized Electrode
Authors: Sun Peng , Sun Tong , Anz Samir , Corey Jason , Tan Yunshi 
Published: April 2014

AbstractSo far, almost all electrochemistry theories are based on an assumption that the size of an electroactive molecule is negligible. However, this assumption will not be true if the size of an electroactive molecule is comparable to or smaller than the size of an electrode being used to study the electroactive molecule. In this paper, the electrochemical behaviors of ferrocenated gold nanoparticles have been studied using an electrode with a radius that is smaller than the radius of the particle. This allows for the observation of phenomena which cannot be explained by conventional electrochemical theories. Also, stochastic collision current, which cannot be observed on a macro‐ or microelectrode, can be directly observed.
Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
Authors: Mladenović Aleksandar R. , Mijin Dušan Ž. , Drmanić Saša Ž. , Vajs Vlatka E. , Jovanović Vladislava M. , Petrović Slobodan D. , Ivić Milka L. Avramov 
Published: April 2014

AbstractThe oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer’s disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
Screening of Specific Gene Mutations Associated with Cystic Fibrosis
Authors: García‐Mendiola Tania , Barreiro Martínez Tegra , Pariente Félix , Molano Jesús , Lorenzo Encarnación 
Published: April 2014

AbstractA selective screening method for detection of gene mutations in highly mutated genes associated with cystic fibrosis is described. The method relies on a disposable DNA electrochemical biosensor based on the use of a selective pentaammine [3‐(2‐phenanthren‐9‐yl‐vinyl)‐pyridine] ruthenium complex as electrochemical indicator. This complex incorporates dual functionalities: the Ru center provides a redox probe and the ligand endows the complex with an intercalative character making it capable of binding preferently to double‐stranded DNA. The approach allows the simultaneous detection of different mutations and the determination of homozygous and heterozygous directly in large PCR amplicons extracted from blood cells. The results agree well to those obtained by High Resolution Melting sequencing suggesting that the proposed biosensing procedure is a robust and sensitive technique for screening mutations.
A Calcium Solid State Ion Selective Minisensor Based on Lipid Films on ZnO Nanorods
Authors: Mitrou Nikolaos , Nikoleli Georgia‐Paraskevi , Nikolelis Dimitrios P. , Psaroudakis Nikolas , Scoullos Michael 
Published: April 2014

AbstractThis article describes the development of a calcium solid minisensor based on lipid films on ZnO nanorods. The lipid film was composed from dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylcic acid (DPPA). The calibration graph was logarithmically related to the concentration of calcium ions in the range from 10−6 to 10−3 M. The response times of the electrode were less than 5 s. No memory effects were observed for this electrode. The reproducibility of the electrode was less than 5 %. The electrode has shown good stability for a period of 1 month. The influence of a wide range of metals and anions as potential interferences was checked. The method was applied to the rapid detection of calcium ions in mineral waters.
Comparing population recovery after insecticide exposure for four aquatic invertebrate species using models of different complexity
Authors: Baveco J. M. (Hans) , Norman Steve , Roessink Ivo , Galic Nika , Brink Paul J. Van den 
Published: April 2014

Abstract

Population models, in particular individual-based models (IBMs), are becoming increasingly important in chemical risk assessment. They can be used to assess recovery of spatially structured populations after chemical exposure that varies in time and space. The authors used an IBM coupled to a toxicokinetic–toxicodynamic model, the threshold damage model (TDM), to assess recovery times for 4 aquatic organisms, after insecticide application, in a nonseasonal environment and in 3 spatial settings (pond, stream, and ditch). The species had different life histories (e.g., voltinism, reproductive capacity, mobility). Exposure was derived from a pesticide fate model, following standard European Union scenarios. The results of the IBM–TDM were compared with results from simpler models: one in which exposure was linked to effects by means of concentration–effect relationships (IBM-CE) and one in which the IBM was replaced by a nonspatial, logistic growth model (logistic). For the first, exposure was based on peak concentrations only; for the second, exposure was spatially averaged as well. By using comparisons between models of different complexity and species with different life histories, the authors obtained an understanding of the role spatial processes play in recovery and the conditions under which the full time-varying exposure needs to be considered. The logistic model, which is amenable to an analytic approach, provided additional insights into the sensitivity of recovery times to density dependence and spatial dimensions. Environ Toxicol Chem 2014;33:???–???. © 2014 SETAC