bluuebunny/crossref_metadata_2025_split huggingface dataset:
Summary of CGT302 Ceramic Gas Turbine Research and Development Program
Authors: Takehara Isashi , Tatsumi Tetsuo , Ichikawa Yoshihiro 
Published: August 2014

The Japanese Ceramic Gas Turbine (CGT) research and development program (FY1988–1998) as a part of the New Sunshine Project funded by the Ministry of International Trade and Industry (MITI) was completed in March 1999. Kawasaki Heavy Industries, Ltd. (KM) participated in this research program from the beginning and developed a twin-shaft CGT with a recuperator, designated as the “CGT302”.
The purposes of this program were: 1) to achieve both a high efficiency and low pollutant emissions level using ceramic components, 2) to prove a multi-fuel capability to be used in co-generation systems, and 3) to demonstrate long-term operation. The targets of this program were: i) to achieve a thermal efficiency of over 42% at a turbine inlet temperature (TIT) of 1350°C, ii) to keep its emissions within the regulated value by the law, and iii) to demonstrate continuous operation for more than a thousand hours at 1200°C TIT.
The CGT302 has successfully attained its targets. In March 1999 the CGT302 recorded 42.1% thermal efficiency, and 31.7 ppm NOx emissions (O2 = 16%) at 1350°C TIT. At this time it had also accumulated over two thousand hours operation at 1200°C.
In this paper, we summarize the development of the CGT302.
Endwall Cavity Flow Effects on Gaspath Aerodynamics in an Axial Flow Turbine: Part I — Experimental and Numerical Investigation
Authors: Hunter Scott D. , Manwaring Steven R. 
Published: August 2014

Axial flow turbine designers are currently using Navier-Stokes flow solvers to reveal the details of the three dimensional flowfield inside individual bladerow passages. This new capability has allowed designers to focus on secondary flow reduction to improve turbine efficiency. These steady bladerow solvers include viscous and film cooling effects and show good agreement with test measurements in the midspan region. However, the difference between computational results and data at the endwalls is significant due to the exclusion of endwall cavity effects. A clear understanding of how the flow entering and exiting the cavity interacts with the gaspath aerodynamics, in conjunction with an accurate computational model, are needed to predict accurately the secondary flow patterns and endwall losses. This investigation confirms that endwall cavity flows have a significant influence on gaspath aerodynamics and that they need to be included in bladerow computations for accurate results.
Part I presents the experimental and computational results from an investigation of the endwall cavity and gaspath flow interaction in a low pressure turbine. Detailed test measurements were obtained in a low speed research turbine using state of the art geometry and served as a benchmark for the computational model. Hot wire and total pressure measurements were taken at multiple planes between bladerows to establish the interaction between the hub cavity and gaspath flows. Ethylene tracer gas was also applied to evaluate secondary flow characteristics of the stator and the migration of the cavity flow through the downstream rotor.
Steady and unsteady computational analyses were utilized to model different combinations of the cavity and bladerow geometries. This building block approached allowed for separation of the flow physics involved in the interaction and identified the geometry and flow features that were critical to producing the best agreement with test data.
In Part II, the development of a source term model for a steady bladerow solver that simulates endwall cavity flows in a low pressure turbine is reviewed. The source term model adequately captured endwall cavity effects and accurately predicted secondary flow in the adjacent bladerow. This source term model gives designers the capability to investigate new ideas of reducing secondary flow in a timely manner, leading to improvements in overall turbine efficiency.
Validation of OSLD and a treatment planning system for surface dose determination in IMRT treatments
Authors: Zhuang Audrey H. , Olch Arthur J. 
Published: August 2014

Purpose:To evaluate the accuracy of skin dose determination for composite multibeam 3D conformal radiation therapy (3DCRT) and intensity modulated radiation therapy (IMRT) treatments using optically stimulated luminescent dosimeters (OSLDs) and Eclipse treatment planning system.Methods:Surface doses measured by OSLDs in the buildup region for open field 6 MV beams, either perpendicular or oblique to the surface, were evaluated by comparing against dose measured by Markus Parallel Plate (PP) chamber, surface diodes, and calculated by Monte Carlo simulations. The accuracy of percent depth dose (PDD) calculation in the buildup region from the authors’ Eclipse system (Version 10), which was precisely commissioned in the buildup region and was used with 1 mm calculation grid, was also evaluated by comparing to PP chamber measurements and Monte Carlo simulations. Finally, an anthropomorphic pelvic phantom was CT scanned with OSLDs in place at three locations. A planning target volume (PTV) was defined that extended close to the surface. Both an 8 beam 3DCRT and IMRT plan were generated in Eclipse. OSLDs were placed at the CT scanned reference locations to measure the skin doses and were compared to diode measurements and Eclipse calculations. Efforts were made to ensure that the dose comparison was done at the effective measurement points of each detector and corresponding locations in CT images.Results:The depth of the effective measurement point is 0.8 mm for OSLD when used in the buildup region in a 6 MV beam and is 0.7 mm for the authors’ surface diode. OSLDs and Eclipse system both agree well with Monte Carlo and/or Markus PP ion chamber and/or diode in buildup regions in 6 MV beams with normal or oblique incidence and across different field sizes. For the multiple beam 3DCRT plan and IMRT plans, the differences between OSLDs and Eclipse calculations on the surface of the anthropomorphic phantom were within 3% and distance‐to‐agreement less than 0.3 mm.Conclusions:The authors’ experiment showed that OSLD is an accurate dosimeter for skin dose measurements in complex 3DCRT or IMRT plans. It also showed that an Eclipse system with accurate commissioning of the data in the buildup region and 1 mm calculation grid can calculate surface doses with high accuracy and has a potential to replacein vivo measurements.
Draft Genome Sequence of Xanthomonas axonopodis pv. allii Strain CFBP 6369
Authors: Gagnevin L. , Bolot S. , Gordon J. L. , Pruvost O. , Vernière C. , Robène I. , Arlat M. , Noël L. D. , Carrère S. , Jacques M.-A. , Koebnik R. 
Published: August 2014

ABSTRACT

We report here the draft genome sequence of
Xanthomonas axonopodis
pv. allii strain CFBP 6369, the causal agent of bacterial blight of onion. The draft genome has a size of 5,425,942 bp and a G+C content of 64.4%.
Genome Sequence of Fusarium oxysporum f. sp.
melonis
Strain NRRL 26406, a Fungus Causing Wilt Disease on Melon
Authors: Ma Li-Jun , Shea Terrance , Young Sarah , Zeng Qiandong , Kistler H. Corby 
Published: August 2014

ABSTRACT

Horizontal chromosome transfer introduces host-specific pathogenicity among members of the
Fusarium oxysporum
species complex and is responsible for some of the most destructive and intractable plant diseases. This paper reports the genome sequence of
F. oxysporum
f. sp.
melonis
(NRRL 26406), a causal agent of
Fusarium
wilt disease on melon.
Draft Genome Sequence of Amycolatopsis mediterranei DSM 40773, a Tangible Antibiotic Producer
Authors: Mukherjee Udita , Saxena Anjali , Kumari Rashmi , Singh Priya , Lal Rup 
Published: August 2014

ABSTRACT

Amycolatopsis mediterranei
DSM 40773 has been of special interest as successors of this strain are in use for the commercial production of rifamycin B. Here we present the draft genome sequence (~10 Mb) of this strain, which contains 108 contigs, 9,198 genes, and has a G+C content of 71.3%.
Finished Genome Sequence of the Unicellular Cyanobacterium
Synechocystis
sp. Strain PCC 6714
Authors: Kopf Matthias , Klähn Stephan , Voss Björn , Stüber Kurt , Huettel Bruno , Reinhardt Richard , Hess Wolfgang R. 
Published: August 2014

ABSTRACT

Synechocystis
sp. strain PCC 6714 is a unicellular cyanobacterium closely related to the popular model organism
Synechocystis
sp. strain PCC 6803. A combination of PacBio SMRT and Illumina GAIIx data results in a highly accurate finished genome sequence that provides a reliable resource for further comparative analyses.
Genome Sequence of Tumor Virus X, a Member of the Genus
Protoparvovirus
in the Family
Parvoviridae
Authors: Vollmers Ellen M. , D'Abramo Anthony , Cotmore Susan F. , Tattersall Peter 
Published: August 2014

ABSTRACT

The orphan parvovirus tumor virus X (TVX) has potent oncolytic activity. Compared to other viruses from the species
Rodent protoparvovirus 1
, TVX has a 111 nucleotide deletion in its nonstructural (NS) gene, a 24 nucleotide insertion in VP1, and a 93 nucleotide repeat initiating from the C-terminus of the capsid gene.
Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance
Authors: Guio H. , Tarazona D. , Galarza M. , Borda V. , Curitomay R. 
Published: August 2014

ABSTRACT

We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American–Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in
rrs
,
tlyA
, and
eis
. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.
The pathway to orthopaedic surgery: a population study of the role of access to primary care and availability of orthopaedic services in Ontario, Canada
Authors: Canizares Mayilee , Davis Aileen M , Badley Elizabeth M 
Published: August 2014

ObjectiveTo examine the impact of access to primary care physicians (PCPs), geographic availability of orthopaedic surgeons, socioeconomic status (SES), proportion of older population (≥65 years) and proportion of rural population on orthopaedic surgeon office visits and orthopaedic surgery.DesignPopulation multilevel study.SettingOntario, Canada.ParticipantsOntario residents 18 years or older who had visits to orthopaedic surgeons or an orthopaedic surgery for musculoskeletal disorders in 2007/2008.Primary and secondary outcomesOffice visits to orthopaedic surgeons and orthopaedic surgery.ResultsAccess to PCPs and the index of geographic availability of orthopaedic surgeons, but not SES, were significantly associated with orthopaedic surgeon office visits. There was a significant interaction between access to PCPs and orthopaedic surgeon geographic availability for the rate of office visits, with access to PCPs being more important in areas of low geographic availability of orthopaedic surgeons. After controlling for office visits with orthopaedic surgeons, the index of geographic availability of orthopaedic surgeons was no longer significantly associated with orthopaedic surgery.ConclusionsThe findings suggest that, particularly, in areas with low access to PCPs or with fewer available orthopaedic surgeons, residents are less likely to have orthopaedic surgeon office visits and in turn are less likely to receive surgery. Efforts to address adequate access to orthopaedic surgery should also include improving and facilitating access to PCPs for referral, particularly in geographic areas with low orthopaedic surgeon availability.
An Interactive, Web-Based High Performance Modeling Environment for Computational Epidemiology
Authors: Deodhar Suruchi , Bisset Keith R. , Chen Jiangzhuo , Ma Yifei , Marathe Madhav V. 
Published: August 2014

We present an integrated interactive modeling environment to support public health epidemiology. The environment combines a high resolution individual-based model with a user-friendly Web-based interface that allows analysts to access the models and the analytics backend remotely from a desktop or a mobile device. The environment is based on a loosely coupled service-oriented-architecture that allows analysts to explore various counterfactual scenarios. As the modeling tools for public health epidemiology are getting more sophisticated, it is becoming increasingly difficult for noncomputational scientists to effectively use the systems that incorporate such models. Thus an important design consideration for an integrated modeling environment is to improve ease of use such that experimental simulations can be driven by the users. This is achieved by designing intuitive and user-friendly interfaces that allow users to design and analyze a computational experiment and steer the experiment based on the state of the system.A key feature of a system that supports this design goal is the ability to start, stop, pause, and roll back the disease propagation and intervention application process interactively. An analyst can access the state of the system at any point in time and formulate dynamic interventions based on additional information obtained through state assessment. In addition, the environment provides automated services for experiment set-up and management, thus reducing the overall time for conducting end-to-end experimental studies.We illustrate the applicability of the system by describing computational experiments based on realistic pandemic planning scenarios. The experiments are designed to demonstrate the system’s capability and enhanced user productivity.
Protocol design contests
Authors: Sivaraman Anirudh , Winstein Keith , Varley Pauline , Batalha João , Goyal Ameesh , Das Somak , Ma Joshua , Balakrishnan Hari 
Published: August 2014

In fields like data mining and natural language processing, design contests have been successfully used to advance the state of the art. Such contests offer an opportunity to bring the excitement and challenges of protocol design---one of the core intellectual elements of research and practice in networked systems---to a broader group of potential contributors, whose ideas may prove important. Moreover, it may lead to an increase in the number of students, especially undergraduates or those learning via online courses, interested in pursuing a career in the field.
We describe the creation of the infrastructure and our experience with a protocol design contest conducted in MIT's graduate Computer Networks class. This contest involved the design and evaluation of a congestion-control protocol for paths traversing cellular wireless networks. One key to the success of a design contest is an unambiguous, measurable objective to compare protocols. In practice, protocol design is the art of trading off conflicting goals with each other, but in this contest, we specified that the goal was to maximize $\log(\mbox{throughput}/\mbox{delay})$. This goal is a good match for applications such as video streaming or videoconferencing that care about high throughput and low interactive delays.
Some students produced protocols whose performance was better than published protocols tackling similar goals. Furthermore, the convex hull of the set of all student protocols traced out a tradeoff curve in the throughput-delay space, providing useful insights into the entire space of possible protocols. We found that student protocols diverged in performance between the training and testing traces, indicating that some students had overtrained ("overfitted") their protocols to the training trace. Our conclusion is that, if designed properly, such contests could benefit networking research by making new proposals more easily reproducible and amenable to such "gamification," improve networked systems, and provide an avenue for outreach.
Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer
Authors: Liu Deli , Xiong Huan , Ellis Angela E. , Northrup Nicole C. , Rodriguez Carlos O. , O'Regan Ruth M. , Dalton Stephen , Zhao Shaying 
Published: August 2014

Abstract
Spontaneously occurring canine mammary cancer represents an excellent model of human breast cancer, but is greatly understudied. To better use this valuable resource, we performed whole-genome sequencing, whole-exome sequencing, RNA-seq, and/or high-density arrays on twelve canine mammary cancer cases, including seven simple carcinomas and four complex carcinomas. Canine simple carcinomas, which histologically match human breast carcinomas, harbor extensive genomic aberrations, many of which faithfully recapitulate key features of human breast cancer. Canine complex carcinomas, which are characterized by proliferation of both luminal and myoepithelial cells and are rare in human breast cancer, seem to lack genomic abnormalities. Instead, these tumors have about 35 chromatin-modification genes downregulated and are abnormally enriched with active histone modification H4-acetylation, whereas aberrantly depleted with repressive histone modification H3K9me3. Our findings indicate the likelihood that canine simple carcinomas arise from genomic aberrations, whereas complex carcinomas originate from epigenomic alterations, reinforcing their unique value. Canine complex carcinomas offer an ideal system to study myoepithelial cells, the second major cell lineage of the mammary gland. Canine simple carcinomas, which faithfully represent human breast carcinomas at the molecular level, provide indispensable models for basic and translational breast cancer research. Cancer Res; 74(18); 5045–56. ©2014 AACR.
89Zr-trastuzumab and 89Zr-bevacizumab PET to Evaluate the Effect of the HSP90 Inhibitor NVP-AUY922 in Metastatic Breast Cancer Patients
Authors: Gaykema Sietske B.M. , Schröder Carolien P. , Vitfell-Rasmussen Joanna , Chua Sue , Oude Munnink Thijs H. , Brouwers Adrienne H. , Bongaerts Alfons H.H. , Akimov Mikhail , Fernandez-Ibarra Cristina , Lub-de Hooge Marjolijn N. , de Vries Elisabeth G.E. , Swanton Charles , Banerji Udai 
Published: August 2014

Abstract
Purpose: HSP90 chaperones have key client proteins that are involved in all hallmarks of breast cancer growth and progression. The primary aim of this clinical trial was to evaluate the feasibility of using 89Zr-trastuzumab PET (for HER2-positive breast cancer) or 89Zr-bevacizumab PET [for estrogen receptor (ER)–positive breast cancer] to determine in vivo degradation of client proteins caused by the novel HSP90 inhibitor NVP-AUY922.
Experimental Design: Of note, 70 mg/m2 NVP-AUY922 was administered intravenously in a weekly schedule to patients with advanced HER2 or ER-positive breast cancer. Biomarker analysis consisted of serial PET imaging with 2[18F]fluoro-2-deoxy-D-glucose (FDG), 89Zr-trastuzumab, or 89Zr-bevacizumab. Response evaluation was performed according to RECIST1.0. FDG, 89Zr-trastuzumab, and 89Zr-bevacizumab distributions were scored visually and quantitatively by calculating the maximum standardized uptake values (SUVmax). In blood samples, serial HSP70 levels, extracellular form of HER2 (HER2-ECD), and pharmacokinetic and pharmacodynamic parameters were measured.
Results: Sixteen patients (ten HER2-positive and six ER-positive tumors) were included. One partial response was observed; seven patients showed stable disease. SUVmax change in individual tumor lesions on baseline versus 3 weeks 89Zr-trastuzumab PET was heterogeneous and related to size change on CT after 8 weeks treatment (r2 = 0.69; P = 0.006). Tumor response on 89Zr-bevacizumab PET and FDG-PET was not correlated with CT response.
Conclusions: NVP-AUY922 showed proof-of-concept clinical response in HER2-amplified metastatic breast cancer. Early change on 89Zr-trastuzumab PET was positively associated with change in size of individual lesions assessed by CT. Clin Cancer Res; 20(15); 3945–54. ©2014 AACR.
Larger A1/M1 Diameter Ratio Predicts Embolic Anterior Cerebral Artery Territorial Stroke
Authors: Shoamanesh Ashkan , Masoud Hesham , Furey Katrina , Duerfeldt Kaylyn , Lau Helena , Romero Jose R. , Pikula Aleksandra , Teal Philip , Nguyen Thanh N. , Kase Carlos S. , Babikian Viken L. 
Published: August 2014

Background and Purpose—
In contrast to middle cerebral artery territory strokes, anterior cerebral artery strokes (ACAS) occur rarely. The low frequency of ACAS, in relation to middle cerebral artery territory strokes, may be explained by differences in ACA and middle cerebral artery anatomy influencing their respective flow-directed embolism rates. We aimed to determine whether variability in ACA anatomy, and in particular A1 segment diameter, is associated with embolic ACAS.

Methods—
Consecutive patients admitted to Boston Medical Center with embolic ACAS were reviewed. Ipsilateral and contralateral A1 diameters, M1 diameters, and terminal internal carotid artery bifurcation angles were measured from computed tomographic angiography and MRI angiography images. We compared these measurements between cases of ACAS and consecutive cases of embolic middle cerebral artery territory strokes.

Results—
The study comprised 55 individuals (27 ACAS, 28 middle cerebral artery territory strokes) with mean age of 69 years. In multivariate regression analysis, larger ipsilateral A1 diameters (odds ratio per 1 mm increment: 8.5; 95% confidence interval, 1.4–53.3) and ipsilateral A1/M1 diameter ratio (odds ratio per 10% increment: 1.8; 95% confidence interval, 1.2–2.9) were associated with ACAS, whereas larger ipsilateral M1 diameters was protective for ACAS (odds ratio per 1 mm increment: 0.8; 95% confidence interval, 0.0–0.9).

Conclusions—
Larger ipsilateral A1 diameters and A1/M1 diameter ratio are associated with embolic ACAS. These findings suggest that A1 diameters and M1 diameters are important in determining the path of emboli that reach the terminal internal carotid artery.
Festbankett oder Henkersmahl? Die zwei Gesichter von Jes 25:6-8
Authors: Maier Michael P. 
Published: August 2014

Biblical scholarship generally considers Is. 25:6-8 one of the most universal salvation oracles. Nevertheless, not only the old translations, but also Jewish exegetes of the Middle Ages understood it as an announcement of doom. A fresh look at the intertextuality of some of the key words, gives new credibility to this interpretation. In fact, a banquet may be occasion of judgment, oil can hint to extravagant ointment, new wine may intoxicate, the covering which is pulled away is sometimes a metaphor for military protection.
After the exegesis, the hermeneutical problem of diverging interpretations is discussed. The two faces of the oracle are seen as the result of the different readings of Israel and the Church. For obvious reasons, Jewish readers identified with the people living on mount Zion, Christian readers with the nations climbing up to it. In order to bridge the abyss, it is necessary to recognize these contrasting receptions and to acknowledge the distinct, but intimately connected roles of Israel and the Gentiles.