bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature‐Dependent Surface‐Enrichment Effects of Imidazolium‐Based Ionic Liquids
Authors: Kolbeck Claudia , Deyko Alexey , Matsuda Takashi , Kohler Florian T. U. , Wasserscheid Peter , Maier Florian , Steinrück Hans‐Peter 
Published: October 2013

AbstractWe present the first systematic study of the influence of temperature on the degree of surface enrichment of 1‐alkyl‐3‐methylimidazolium‐based ionic liquids (ILs). Using angle‐resolved X‐ray photoelectron spectroscopy, we demonstrate that the degree of surface enrichment strongly decreases with increasing temperature for all the studied ILs. For ILs with the same cation, but different anions, [C8C1Im]Br, [C8C1Im][TfO] and [C8C1Im][Tf2N], no significant differences of the temperature‐induced partial loss of surface enrichment are found. Measurements for [C4C1Im][TfO], [C8C1Im][TfO] and [C18C1Im][TfO] indicate a small effect of the chain length. For [C18C1Im][TfO], a continuous decrease of alkyl surface enrichment is found with increasing temperature, with no abrupt changes at the phase‐transition temperature from the smectic A to the isotropic phase, indicating that the surface enrichment is not affected by this phase transition.
Micropatterned Surfaces for the Study of Cancer and Endothelial Cell Interactions with Hyaluronic Acid
Authors: Smulovitz Courtney , Dickinson Laura E. , Gerecht Sharon 
Published: October 2013

AbstractHyaluronic acid (HA) is a glycosaminoglycan component of the extracellular matrix. Studies have shown that various cancers exhibit high levels of HA content, and that an increased amount of HA corresponds to poor patient prognosis. HA has been implicated in cellular interactions that are associated with cancer progression, including cell adhesion, motility, and differentiation. Micropatterned functional HA surfaces were developed to study interactions between cancer cells and HA. The adhesion and migration of cancer cells representing different stages of tumorigenesis were examined. A similar surface patterning approach was used to create HA regions next to fibronectin in two‐ and three‐dimensional settings to visualize and study the interactions between cancer and endothelial cells. The ability to observe the dynamic interactions of cancer cells and angiogenesis within a HA‐rich microenvironment will improve the fundamental understanding of cancer progression and contribute to the development of advanced therapeutic targets.
Artificial Antigen‐Presenting Interfaces in the Service of Immunology
Authors: Platzman Ilia , Janiesch Jan‐Willi , Matić Jovana , Spatz Joachim P. 
Published: October 2013

AbstractWhile the beneficial impact of modifying and/or targeting T lymphocytes is becoming increasingly accepted in the treatment of different diseases, the road towards cell‐based immunotherapy is still long and winding. Major challenges that remain include, amongst others, the guidance and exquisite regulation of immune processes ex vivo. In part, this is due to the difficulties of simulating ex vivo the intimate cellular interactions that occur between T cells and antigen‐presenting cells (APCs). The fate of T cells is not solely regulated by the presence of certain molecules on the surface of APCs but also by their density and spatial distribution on the micro‐ and nanometric scale. Moreover, mechanical properties of APCs and force‐dependent conformational changes during the formation of an immunological synapse (IS; a highly organized supramolecular complex at the T cellAPC interface), play a crucial role in T cell fate regulation. Various different technical means have been developed to create APC substitutes that are able to simulate ex vivo signals originating from naturally occurring APCs. Here, we review the performance of APC surrogates and discuss their contribution to understanding mechanisms underlying the ability of T cells to perform the “intelligent” mission of acquiring, processing and responding to environmental information.
The Evolution of Tumor‐Targeted Drug Delivery: From the EPR Effect to Nanoswimmers
Authors: Zoabi Nour , Golani‐Armon Adi , Zinger Assaf , Reshef Maayan , Yaari Zvi , Vardi‐Oknin Dikla , Shatsberg Zohar , Shomar Aseel , Shainsky‐Roitman Janna , Schroeder Avi 
Published: October 2013

AbstractTherapeutic nanotechnologies have made great progress over the past decade. Skepticism has been replaced by the understanding that precision at the nanoscale allows improved treatment modalities in humans. Principles for designing tumor‐targeted drug delivery systems are described. At first, the enhanced permeability and retention (EPR) effect was the major targeting mode, with up to 10 % of the injected dose actually reaching tumors. To improve cellular uptake, sugars, antibodies, peptides or other ligands were added to the surface of nanotherapeutics. These can be coupled with external magnetic fields or ultrasonic waves to propel iron oxide or gas‐filled particles towards the disease site. Next‐generation drug delivery systems will be capable of autonomously swimming towards the disease site and penetrating deep tissue, independent of blood or lymphatic flow. This has been shown to some extent with modified, drug‐producing, bacteria. Interestingly, sperm may be nature’s best example of a multifunctional, targeted, high‐fidelity, self‐propelled, delivery system that we can learn from.
Catalytic Oxidative Cyclisation Reactions of 1,6‐Enynes: A Critical Comparison Between Gold and Palladium
Authors: Nunes dos Santos Comprido Laura , Hashmi A. Stephen K. 
Published: October 2013

AbstractIn transition‐metal catalysis, similar reactivities are often described for related metals, thereby resulting in the formation of similar/identical products. However, only in rare cases can similar/identical product be obtained by using non‐related metals. Amongst these reactions is the oxidative cyclisation of 1,6‐enynes by using palladium or gold. Similarities and differences will be discussed with a special focus on the diastereo‐ and enantioselective course of the reaction.
Biomimetic Platforms for Tissue Engineering
Authors: Vunjak‐Novakovic Gordana 
Published: October 2013

AbstractBioengineering platforms that combine cell/tissuespecific transport and signaling with precise control of culture conditions and multiparametric insights into the cell function are critical to our efforts to study tissue development, regeneration, and disease under conditions that predict the human in vivo context. Because living cells respond to the entire context of their environment – in vivo and in vitro, under normal and pathological conditions – the biological foundation of our bioengineering designs that is often described as the “biomimetic paradigm” is critical for unlocking the biological potential of the cells. This brief review focuses on some of the key principles for designing and using biologically inspired engineering platforms. Four examples are used to illustrate the designs and applications of biomimetic platforms.
Silk for Drug Delivery Applications: Opportunities and Challenges
Authors: Seib F. Philipp , Kaplan David L. 
Published: October 2013

AbstractSilk fibers have been used in textiles for more than 5,000 years and as a suturing material for many centuries. The recent development of new applications for silks include drug delivery. An overview of this new field is provided, summarizing the development of emerging drug delivery applications which include silk‐based nanomedicines and transdermal delivery systems We also highlight some of the challenges in developing silk‐based drug delivery systems.
Drug‐Delivery Systems for Tunable and Localized Drug Release
Authors: Timko Brian P. , Kohane Daniel S. 
Published: October 2013

AbstractDrug‐delivery systems can be designed to provide localized drug release with a variety of customizable release profiles. Passive systems enable sustained, zero‐order release for days or weeks, while remotely triggered systems enable the timing and dose of drug release to be controlled by the patient or physician. Release profiles can be engineered to match the requirements of particular ailments. We review on‐demand drug‐delivery systems that release a therapeutic in response to magnetic, near‐infrared, or UV fields; such systems could extend the capabilities of sustained release systems by incorporating programmed dosing regimens.
Earth's collision with a solar filament on 21 January 2005: Overview
Authors: Kozyra J. U. , Manchester W. B. , Escoubet C. P. , Lepri S. T. , Liemohn M. W. , Gonzalez W. D. , Thomsen M. W. , Tsurutani B. T. 
Published: October 2013

AbstractOn 21 January 2005, one of the fastest interplanetary coronal mass ejections (ICME) of solar cycle 23, containing exceptionally dense plasma directly behind the sheath, hit the magnetosphere. We show from charge‐state analysis that this material was a piece of the erupting solar filament and further, based on comparisons to the simulation of a fast CME, that the unusual location of the filament material was a consequence of three processes. As the ICME decelerated, the momentum of the dense filament material caused it to push through the flux rope toward the nose. Diverging nonradial flows in front of the filament moved magnetic flux to the sides of the ICME. At the same time, reconnection between the leading edge of the ICME and the sheath magnetic fields worked to peel away the outer layers of the flux rope creating a remnant flux rope and a trailing region of newly opened magnetic field lines. These processes combined to move the filament material into direct contact with the ICME sheath region. Within 1 h after impact and under northward interplanetary magnetic field (IMF) conditions, a cold dense plasma sheet formed within the magnetosphere from the filament material. Dense plasma sheet material continued to move through the magnetosphere for more than 6 h as the filament passed by the Earth. Densities were high enough to produce strong diamagnetic stretching of the magnetotail despite the northward IMF conditions and low levels of magnetic activity. The disruptions from the filament collision are linked to an array of unusual features throughout the magnetosphere, ionosphere, and atmosphere. These results raise questions about whether rare collisions with solar filaments may, under the right conditions, be a factor in producing even more extreme events.
Pharmacophore Model Refinement for 11β‐Hydroxysteroid Dehydrogenase Inhibitors: Search for Modulators of Intracellular Glucocorticoid Concentrations
Authors: Vuorinen Anna , Nashev Lyubomir G. , Odermatt Alex , Rollinger Judith M. , Schuster Daniela 
Published: October 2013

Abstract11β‐Hydroxysteroid dehydrogenases (11β‐HSD) control the intracellular concentrations of glucocorticoids: 11β‐HSD1 converts the inactive cortisone to the active cortisol, and 11β‐HSD2 is responsible for the opposite reaction. Inhibition of 11β‐HSD1 is beneficial in the treatment of metabolic syndrome, whereas 11β‐HSD2 inhibition leads to hypertension. Therefore, 11β‐HSD1 inhibitors should be selective over 11β‐HSD2. To support drug discovery and toxicological studies, we have previously reported pharmacophore models for 11β‐HSD1 and 2 inhibition. These models represent the common chemical features of 11β‐HSD inhibitors, which were used as virtual screening filter. Since new inhibitors are constantly discovered, the quality of the pharmacophore models has to be evaluated in order to maintain a good predictive power. In this study, we report a systematic evaluation and refinement of our pharmacophore model collection. We employed our models for virtual screening, especially focusing on the 11β‐HSD2 inhibition. In total, 42 compounds were biologically evaluated and among these we discovered 17 11β‐HSD inhibitors that decreased the residual enzyme activity to 50% or less at the concentration of 20 µM. The experimental 11β‐HSD1 and 2 readouts from these compounds were used for further model refinement. Evaluation metrics were applied for a quantitative comparison of the old and newly generated models which resulted in a set of improved pharmacophore models offering reliable in silico tools for the identification of novel and selective 11β‐HSD inhibitors.
Mood and anxiety disorders, the association with presenteeism in employed members of a general population sample
Authors: Esposito Eleonora , Wang Jian Li , Williams Jeanne V.A. , Patten Scott B. 
Published: October 2013

SummaryAims– The term “presenteeism” is used to describe workers who are present in the workforce, but who are not functioning at full capacity. The objective of the study was to describe the impact of mood and anxiety disorders on presenteeism in a population sample.Methods– Random digit dialing was used to select a sample of n= 3345 subjects between the ages of 18 and 64. A computer assisted telephone interview that included theMini Neuropsychiatric Diagnostic Interview(MINI), theStanford Presenteeism Scale6 (SPS-6) and a pharmacoepidemiology module was administered.Results– Among subjects with comorbid mood and anxiety disorders 75.0% reported interference with their work compared with only 13.3% of subjects without mood or anxiety disorders. Mood and anxiety disorders were associated with lower presenteeism ratings. Regression analysis uncovered a significant gender by anxiety disorder interaction, indicating that the effect of anxiety disorders was greater in men than women.Conclusions– This is the first study to report the impact of mental disorders on presenteeism in a general population sample. The results confirm that the problem of presenteeism is not restricted to specific occupational groups, but is instead a widespread problem in the general population.Declaration of Interest: This study was funded by the Alberta Depression Initiative through the Institute of Health Economics (www.ihe.ab.ca). Dr. Esposito was supported by an International Resident Fellowship from the University of Calgary. Dr. Patten is a Health Scholar with the Alberta Heritage Foundation for Medical Research and a Fellow with the Institute of Health Economics. Dr. Wang is a New Investigator with the Canadian Institutes for Health Research.
iPEAP: integrating multiple omics and genetic data for pathway enrichment analysis
Authors: Sun Haoqi , Wang Haiping , Zhu Ruixin , Tang Kailin , Gong Qin , Cui Juan , Cao Zhiwei , Liu Qi 
Published: October 2013

Abstract
Summary: A challenge in biodata analysis is to understand the underlying phenomena among many interactions in signaling pathways. Such study is formulated as the pathway enrichment analysis, which identifies relevant pathways functional enriched in high-throughput data. The question faced here is how to analyze different data types in a unified and integrative way by characterizing pathways that these data simultaneously reveal. To this end, we developed integrative Pathway Enrichment Analysis Platform, iPEAP, which handles transcriptomics, proteomics, metabolomics and GWAS data under a unified aggregation schema. iPEAP emphasizes on the ability to aggregate various pathway enrichment results generated in different high-throughput experiments, as well as the quantitative measurements of different ranking results, thus providing the first benchmark platform for integration, comparison and evaluation of multiple types of data and enrichment methods.
Availability and implementation: iPEAP is freely available at http://www.tongji.edu.cn/∼qiliu/ipeap.html.
Contact: qiliu@tongji.edu.cn or zwcao@tongji.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
Impacts of SSIIa‐A Null Allele on Durum Wheat Noodle Quality
Authors: Martin John M. , Hogg Andrew C. , Hofer Petrea , Manthey Frank A. , Giroux Michael J. 
Published: October 2013

ABSTRACTA small increase in amylose content may impact end‐product quality of wheat. The effect of elevated amylose content in durum wheat is not known. We surveyed 255 durum wheat accessions and found two genotypes that lacked the SGP‐A1 protein. These genotypes were crossed to Mountrail, an adapted durum genotype, to create populations segregating for the SSIIa‐Ab null allele. Our goal was to determine the influence of allelic variation at the SSIIa‐A locus on semolina properties and end‐product quality with noodles as a test product. Amylose content increased 3% and cooked noodle firmness increased 2.8 g·cm for the SSIIa‐Ab class compared with the SSIIa‐Aa class for the PI 330546 source, but no change in either trait was detected between classes for the IG 86304 source. The SSIIa‐Ab class had a 10% reduction in flour swelling compared with the SSIIa‐Aa class for both crosses. Grain protein and semolina yield did not differ between SSIIa‐A classes. The relationship between flour swelling power and noodle firmness did not differ between SSIIa‐A allelic classes within a cross. The different results for amylose content and noodle firmness between these sources may be because the two sources of the SSIIa‐Ab null mutation contributed different linkages to the segregating populations. Results show that the SSIIa‐Ab allele could be used to produce durum‐based products that are slightly more firm in texture. However, the effect of the SSIIa‐Ab allele may depend on the source.
First Report of the Root-Knot Nematode Meloidogyne arenaria Infecting Noni in China
Authors: Fu M. Y. , Wang H. F. , Chen M. C. 
Published: October 2013

Noni (Morinda citrifolia) is an important medicinal plant and its fruit and root are of high value. In recent years, noni has been cultivated widely on Hainan Island, China. A survey of eight commercial noni fields in four counties found that most fields had plants with symptoms consistent with damage caused by root-knot nematodes. Above-ground symptoms included reduced vigor, plant stunting, and chlorosis. Affected roots were galled, swollen, cracked, and rotten. Fruit loss associated with diseased plants was quantified as 85%. In each field, three samples were taken consisting of 15 cm wide × 20 cm deep soil (containing roots). The nematode population was extracted and quantified according to Barker (1). Nematodes were found in all soil and root samples with population densities ranging from 450 to 835 eggs and second-stage juveniles (J2s) per 200 g subsample of soil, and 685 to 985 eggs and J2s per 10 g sub-sample of fresh roots. Three single egg masses were respectively hand-picked from one sample of diseased noni roots and inoculated onto tomato plants grown with sterilized soil at 20 to 28°C in the greenhouse. After 8 weeks, nematodes were extracted from the roots of tomato plants and identified by morphology, enzyme analysis, and molecular characterization. Morphology of the female perineal patterns showed a low dorsal arch with large lateral lines separating the striae of the dorsal and ventral sectors, leading to the tail terminus; and wavy, coarse striae with forking at lateral lines and short irregular striae near the lateral lines. Enzyme analysis of the esterase phenotype was also typical of the A1 phenotype in M. arenaria. Based on the perineal pattern and esterase phenotype, the Meloidogyne species was identified as M. arenaria (Est A1) (3). Total genomic DNA was extracted from ca. 10 μl of packed second-stage juveniles (J2s) using the method of Cenis (2). The primers C2F3 (5′-GGTCAATGTTCAGAAATTTGTGG-3′) and 1108 (5′-TACCTTTGACCAATCACGCT-3′) (4) was used to amplify the intergenic region between COII and LrRNA genes of the mtDNA and an amplification product (1,700 bp) was obtained, similar to M. hispanica, M. incognita, and M. javanica. Root-knot nematodes (Meloidogyne spp.) have been reported to be cause disease on noni in Hawaii. However, to our knowledge, this is the first report of M. arenaria (Est A1) infecting noni in China. References: (1) K. R. Barker. Pp. 19 in: An Advanced Treatise on Meloidogyne. Vol. II, Methodology. K. R. Barker et al. eds. North Carolina State University Graphics, Raleigh, 1985. (2) J. L. Cenis. Phytopathology 83:76,1993. (3) P. E. Esbenshade and A. C. Triantaphyllou. J. Nematol. 17:6,1990. (4) T. O. Power and T. S. Harris J. Nematol. 25:1,1993.
No sign of quitting: incidental exposure to “no smoking” signs ironically boosts cigarette‐approach tendencies in smokers
Authors: Earp Brian D. , Dill Brendan , Harris Jennifer L. , Ackerman Joshua M. , Bargh John A. 
Published: October 2013

AbstractThe unconscious mind tends to disregard negations in its processing of semantic meaning. Therefore, messages containing negated concepts can ironically prime mental representations and evaluations that are opposite to those intended. We hypothesized that the subtle presentation of a negated concept (e.g., “no smoking”) would activate ironic motivational orientations as well. We tested this hypothesis in a public health context. Smokers viewed photographs in which “no smoking” signs were either inconspicuously embedded (prime condition) or edited out (control condition). Primed smokers showed amplified automatic approach tendencies toward smoking‐related stimuli, but not toward smoking‐unrelated stimuli: an ironic motivational response to exposure to the signs. Since passive priming effects generally serve to facilitate forms of action, not inhibit them, antismoking and other public health campaigns may ironically increase the very behaviors they seek to reduce.
Draft Genome Sequence of the Mycobacterium tuberculosis Strain 43-16836, Belonging to the Indo-Oceanic Lineage, Isolated From Tuberculous Meningitis in Thailand
Authors: Viratyosin W. , Kulawonganunchai S. , Smittipat N. , Juthayothin T. , Penpassakarn P. , Pasomsub E. , Chantratita W. , Chaiprasert A. , Palittapongarnpim P. 
Published: October 2013

ABSTRACT

We present the draft genome sequence of
Mycobacterium tuberculosis
strain 43-16836, belonging to the Indo-Oceanic lineage, isolated from a tuberculous meningitis patient in Thailand. The genome is 4,381,942 bp long with 4,316 protein-coding genes and contains new single nucleotide polymorphisms (SNPs), including SNPs of genes that may encode cell wall components and possibly influence virulence.
Draft Genome Sequences of Two O104:H21 Escherichia coli Isolates Causing Hemorrhagic Colitis during a 1994 Montana Outbreak Provide Insight into Their Pathogenicity
Authors: Gonzalez-Escalona Narjol , McFarland Melinda A. , Rump Lydia V. , Payne Justin , Andrzejewski Denis , Brown Eric W. , Evans Peter S. , Croley Timothy R. 
Published: October 2013

ABSTRACT

We sequenced the genomes of two strains of O104:H21 enterohemorrhagic
Escherichia coli
(EHEC) isolated during an outbreak of hemorrhagic colitis in Montana in 1994. These strains carried a plasmid that contains several virulence genes not present in pO157. The genome sequences will improve phylogenetic analysis of other non-O157
E. coli
strains in the future.