bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elite Female Authors in the Field of Power in Eighteenth‐Century Portugal: Epistolary Writing as Part of a Political Strategy
Authors: Bello Vázquez Raquel 
Published: June 2015

AbstractThis paper explores the role of Enlightenment women through an analysis of their social behaviour. The semi‐public and semi‐private features of an epistolary corpus reveal the boundaries marking the accepted pattern for women's intervention in the cultural field at that time, and behaviours that transgress these boundaries. This research focuses on eighteenth‐century Portugal in the context of other cultural spaces, in order to establish parameters useful for the study of the role of women's in eighteenth‐century cultural fields.
Transversus abdominis plane (TAP) block after robot‐assisted laparoscopic hysterectomy: a randomised clinical trial
Authors: Torup H. , Bøgeskov M. , Hansen E. G. , Palle C. , Rosenberg J. , Mitchell A. U. , Petersen P. L. , Mathiesen O. , Dahl J. B. , Møller A. M. 
Published: June 2015

BackgroundTransversus abdominis plane (TAP) block is widely used as a part of pain management after various abdominal surgeries. We evaluated the effect of TAP block as an add‐on to the routine analgesic regimen in patients undergoing robot‐assisted laparoscopic hysterectomy.MethodsIn a prospective blinded study, 70 patients scheduled for elective robot‐assisted laparoscopic hysterectomy were randomised to receive either TAP block (ropivacaine 0.5%, 20 ml on each side) or sham block (isotonic saline 0.9%, 20 ml on each side). All patients had patient‐controlled analgesia (PCA) with morphine on top of paracetamol and ibuprofen or diclofenac. For the first 24 post‐operative hours, we monitored PCA morphine consumption and pain scores with visual analogue scale (VAS) at rest and while coughing. Post‐operative nausea and number of vomits (PONV) were recorded.ResultsSixty‐five patients completed the study, 34 receiving TAP block with ropivacaine and 31 receiving sham block with isotonic saline. We found no differences in median (interquartile range) morphine consumption the first 24 h between the TAP block group [17.5 mg (6.9–36.0 mg)] and the placebo group [17.5 mg (2.9–38.0 mg)] (95% confidence interval 10.0–22.6 mg, P = 0.648). No differences were found for VAS scores between the two groups, calculated as area under the curve/1–24 h, neither at rest (P = 0.112) nor while coughing (P = 0.345), or for PONV between groups.ConclusionsIn our study, the TAP block combined with paracetamol and Nonsteroidal anti‐inflammatory drugs (NSAID) treatment, had no effect on morphine consumption, VAS pain scores, or frequency of nausea and vomiting after robot‐assisted laparoscopic hysterectomy compared with paracetamol and NSAID alone.
Theory of Mind Difficulties in Patients with Alcohol Dependence: Beyond the Prefrontal Cortex Dysfunction Hypothesis
Authors: Maurage François , de Timary Philippe , Tecco Juan Martin , Lechantre Stéphane , Samson Dana 
Published: June 2015

BackgroundPrevious studies have shown that alcohol‐dependent (AD) individuals have difficulties inferring other people's emotion, understanding humor, and detecting a faux pas. This study aimed at further understanding the nature of such “Theory of Mind” (ToM) difficulties.MethodsA total of 34 recently detoxified AD and 34 paired controls were compared based on 2 nonverbal and video‐based false belief tasks. These tasks were designed to identify 3 different types of deficits: (i) a deficit in dealing with the general task demands, (ii) a selective deficit in self‐perspective inhibition, and (iii) a deficit in tracking the other person's mental state. (i) and (ii) are compatible with the hypothesis of a prefrontal cortex dysfunction being at the origin of AD individuals’ social difficulties, while (iii) would suggest the possible contribution of a dysfunction of the temporo‐parietal junction in explaining the social difficulties.ResultsGroup analyses highlighted that AD individuals performed worse on the 2 false belief tasks than controls. Individual analyses showed, however, that just under half of the AD individuals were impaired compared to controls. Moreover, most of the AD individuals who were impaired showed a deficit in tracking the other person's belief. This deficit was linked to disease‐related factors such as illness duration, average alcohol consumption, and craving but not to general reasoning abilities, depression, anxiety, or demographic variables.ConclusionsJust under half of the AD individuals tested showed a ToM deficit, and in most cases, the deficit concerned the tracking of other people's mental states. Such a type of deficit has previously been associated with lesions to the temporo‐parietal brain areas, indicating that a prefrontal cortex dysfunction may not be the sole origin of the social cognition deficits observed in alcohol dependence.
Clinical and demographic characteristics predictive of treatment outcomes for certolizumab pegol in moderate to severe Crohn's disease: analyses from the 7‐year PRECiSE 3 study
Authors: Sandborn W. J. , Melmed G. Y. , McGovern D. P. B. , Loftus E. V. , Choi J. M. , Cho J. H. , Abraham B. , Gutierrez A. , Lichtenstein G. , Lee S. D. , Randall C. W. , Schwartz D. A. , Regueiro M. , Siegel C. A. , Spearman M. , Kosutic G. , Pierre‐Louis B. , Coarse J. , Schreiber S. 
Published: June 2015

SUMMARYBackgroundClinical factors were previously identified as predictors of short‐term treatment efficacy in Crohn's disease (CD). The PRECiSE 3 (P3) 7‐year trial provides an opportunity to study predictors of short‐ and long‐term clinical remission among CD patients treated with certolizumab pegol (CZP).AimTo identify factors that influence long‐term remission of CD with CZP treatment.MethodsPatients who had completed placebo‐controlled studies (PRECiSE 1/PRECiSE 2, P1/P2) enrolled in P3 and received open‐label CZP 400 mg every 4 weeks up to 7 years. Baseline predictors included, but were not limited to, smoking status, disease duration, prior inflammatory bowel disease (IBD) surgery, Harvey–Bradshaw Index (HBI), albumin, haematocrit and CZP exposure; association with time to initial remission (HBI ≤4) was tested for patients who received CZP in P1/P2; time to loss of remission/frequency of maintenance of remission was also tested. Univariate analyses and multivariate Cox or logistic regression models were used.ResultsPredictors for initial remission (N = 377) included age, haematocrit, prior IBD surgery and entry HBI (P < 0.05 for all). Predictors for loss of remission (N = 437) included HBI, serum albumin concentration, haematocrit, smoking status and exposure. Predictors of maintenance of remission (N = 437) included haematocrit, IBD surgery, HBI, disease duration, serum albumin concentration and exposure. Significant predictors were confirmed with stepwise multivariate regression models.ConclusionsThese analyses identified several influential parameters for short‐and long‐term remission of Crohn's disease with certolizumab pegol treatment. The data yield valuable hypotheses regarding factors that influence certolizumab pegol treatment. More investigation is needed.(ClinicalTrials.gov identifier NCT00552058).
Guideline of guidelines: urinary incontinence
Authors: Syan Raveen , Brucker Benjamin M. 
Published: June 2015

The objective of the article is to review key guidelines on the management of urinary incontinence (UI) to guide clinical management in a practical way. Guidelines produced by the European Association of Urology (updated in 2014), the Canadian Urological Association (updated in 2012), the International Consultation on Incontinence (updated in 2012), and the National Collaborating Centre for Women's and Children's Health (updated in 2013) were examined and their recommendations compared. In addition, specialised guidelines produced by the collaboration between the American Urological Association and the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction on overactive bladder and the use of urodynamics were reviewed. The Appraisal of Guidelines for Research and Evaluation II (AGREE) instrument was used to evaluate the quality of these guidelines. There is general agreement between the groups on the recommended initial evaluation and the use of conservative therapies for first‐line treatment, with a limited role for imaging or invasive testing in the uncomplicated patient. These groups have greater variability in their recommendations for invasive procedures; however, generally the mid‐urethral sling is recommended for uncomplicated stress UI, with different recommendations on the approach, as well as the comparability to other treatments, such as the autologous fascial sling. This ‘Guideline of Guidelines’ provides a summary of the salient similarities and differences between prominent groups on the management of UI.
Clinical characteristics and quality‐of‐life in patients surviving a decade of prostate cancer with bone metastases
Authors: Klaff Rami , Berglund Anders , Varenhorst Eberhard , Hedlund Per Olov , Jǿnler Morten , Sandblom Gabriel ,   the Scandinavian Prostate Cancer Group (SPCG) Study No. 5
Published: June 2015

ObjectiveTo describe characteristics and quality‐of‐life (QoL), and to define factors associated with long‐term survival in a subgroup of patients with prostate cancer with M1b disease.Patients and MethodsThe study was based on 915 patients from a prospective randomised multicentre trial (No. 5) by the Scandinavian Prostate Cancer Group, comparing parenteral oestrogen with total androgen blockade. Long‐term survival was defined as patients having an overall survival of ≥10 years, and logistic regression models were constructed to identity clinical predictors of survival. QoL during follow‐up was assessed using the European Organisation for Research and Treatment of Cancer Quality‐of‐Life Questionnaire – C30 version 1 (EORTC‐C30) ratings.ResultsIn all, 40 (4.4%) of the 915 men survived for >10 years. Factors significantly associated with increased likelihood of surviving for >10 years in the univariate analyses were: absence of cancer‐related pain; Eastern Cooperative Oncology Group (ECOG) performance status of <2; negligible analgesic consumption; T‐category of 1–2; prostate‐specific antigen (PSA) level of <231 μg/L; and a Soloway score of 1. In the multivariate analyses, ECOG performance status of <2, PSA level of <231 μg/L, and Soloway score of 1, were all independent predictors of long‐term survival. All subscales of the EORTC‐C30 were higher in this group than for patients with short survival, but slowly declined over the decade.ConclusionA subgroup of patients with prostate cancer with M1b disease and certain characteristics showed a positive long‐term response to androgen‐deprivation therapy with an acceptable QoL over a decade or more. Independent predictors of long‐term survival were identified as ECOG performance status of <2, limited extent of bone metastases (Soloway score of 1), and a PSA level of <231 μg/L at the time of enrolment.
The Swiss National Registry for Primary Immunodeficiencies: report on the first 6 years’ activity from 2008 to 2014
Authors: Marschall K , Hoernes M , Bitzenhofer-Grüber M , Jandus P , Duppenthaler A , Wuillemin W A , Rischewski J , Boyman O , Heininger U , Hauser T , Steiner U , Posfay-Barbe K , Seebach J , Recher M , Hess C , Helbling A , Reichenbach J ,   Swiss PID Registry Working Group
Published: June 2015

Summary
The Swiss National Registry for Primary Immunodeficiency Disorders (PID) was established in 2008, constituting a nationwide network of paediatric and adult departments involved in the care of patients with PID at university medical centres, affiliated teaching hospitals and medical institutions. The registry collects anonymized clinical and genetic information on PID patients and is set up within the framework of the European database for PID, run by the European Society of Immunodeficiency Diseases. To date, a total of 348 patients are registered in Switzerland, indicating an estimated minimal prevalence of 4·2 patients per 100 000 inhabitants. Distribution of different PID categories, age and gender are similar to the European cohort of currently 19 091 registered patients: ‘predominantly antibody disorders’ are the most common diseases observed (n = 217/348, 62%), followed by ‘phagocytic disorders’ (n = 31/348, 9%). As expected, ‘predominantly antibody disorders’ are more prevalent in adults than in children (78 versus 31%). Within this category, ‘common variable immunodeficiency disorder’ (CVID) is the most prevalent PID (n = 98/217, 45%), followed by ‘other hypogammaglobulinaemias’ (i.e. a group of non-classified hypogammaglobulinaemias) (n = 54/217, 25%). Among ‘phagocytic disorders’, ‘chronic granulomatous disease’ is the most prevalent PID (n = 27/31, 87%). The diagnostic delay between onset of symptoms and diagnosis is high, with a median of 6 years for CVID and more than 3 years for ‘other hypogammaglobulinaemias’.
Gene profile of soluble growth factors involved in angiogenesis, in an adipose‐derived stromal cell/endothelial cell co‐culture, 3D gel model
Authors: Cun Xiangzhu , Xie Jing , Lin Shiyu , Fu Na , Deng Shuwen , Xie Qiang , Zhong Juan , Lin Yunfeng 
Published: June 2015

AbstractObjectivesThe aim of this study was to investigate gene expressions of growth factors for angiogenesis, in a three‐dimensional (3D) gel populated with adipose‐derived stromal cells (ASCs) and endothelial cells (ECs) in co‐culture.Materials and methodsThe 3D gel, mixed with green fluorescent protein (GFP)‐positive ASCs and DsRed‐Express‐positive ECs, 1:1 ratio, was established in vitro. The phenomenon of angiogenesis was observed using confocal microscopy. To detect gene expressions for growth factor proteins in both ASCs and ECs, transwell co‐culture was used, and cell lysate samples were collected at 1, 3, 5 and 7 days. Semi‐quantitative polymerase chain reaction (PCR) was conducted to quantify mRNA expressions of the growth factors.ResultsAngiogenesis was first observed in the gels by 7 days post‐implantation. Over this time in ECs, genes coding for VEGFA/B, IGF‐1, HIF‐1α, FGF‐1/‐2 and BMP‐5/‐7 significantly increased. Meanwhile in ASCs, genes coding for VEGFA/B, IGF‐1, HIF‐1α, FGF‐1/‐2 and BMP‐6 also were significantly enhanced. In particular, increased amounts of IGF‐1 and HIF‐1α in both ECs and ASCs were prominent relative to other factors.ConclusionsContact co‐culture with ASCs and ECs at 1:1 ratio, in the 3D gel promoted angiogenesis; non‐contact co‐culture further confirmed gene expressions for growth factors, VEGFA/B, IGF‐1, HIF‐1α and FGF‐1/‐2 in both ASCs and ECs; BMP‐5/‐7 in ECs and BMP‐6 in ASCs were also confirmed. This establishment of growth factor expression seemed to be responsible for enhancement of angiogenesis. This indicates that these factors could be utilized as targets for engineered angiogenesis.
Relation of perinatal risk and early parenting to executive control at the transition to school
Authors: Clark Caron A.C. , Woodward Lianne J. 
Published: June 2015

AbstractExecutive control (EC) develops rapidly during the preschool years and is central to academic achievement and functional outcome. Although children with perinatal adversity are at known risk for EC impairments, little is known about the underlying nature of these impairments or the mechanisms that contribute to their development over time. Drawing on a cohort of 110 high‐risk children born very preterm (VPT; < 33 weeks / < 1500 g) and 113 healthy full‐term children, this study examined the implications of perinatal adversity and early parenting for children's EC as they transitioned to formal schooling. Parent supportive presence, intrusiveness, and parent–child synchrony were observed during a series of problem‐solving tasks at ages 2 and 4 years. At age 6, children completed a comprehensive battery of EC tasks. Academic outcomes were assessed at age 9. The VPT group showed global EC impairments at age 6, although the unitary factor that best characterized the structure of EC was the same in both groups. High‐risk dyads were characterized by more intrusive and less synchronous parent–child interactions in early childhood, which in turn predicted poorer child EC at age 6. EC partially mediated the relation of risk status to poorer academic achievement at age 9. Findings demonstrate the cumulative effects of perinatal adversity on children's EC in the crucial transition to schooling. They also highlight the importance of the parent–child relationship as a target for intervention efforts to help mitigate these effects.
Early Impairment of Cardiac Function and Asynchronization of Systemic Amyloidosis with Preserved Ejection Fraction Using Two‐Dimensional Speckle Tracking Echocardiography
Authors: Huang He , Jing Xian‐chao , Hu Zhang‐xue , Chen Xi , Liu Xiao‐qin 
Published: June 2015

AimsTo observe the ventricular global and regional function of the patients with systemic amyloidosis using two‐dimensional speckle tracking echocardiography.MethodsThe study enrolled 31 consecutive biopsy‐proved patients with systemic amyloidosis who underwent echocardiographic examination and EF ≥ 55% and 37 age‐ and gender‐matched healthy controls. We compared systolic strain and strain rate, diastolic strain rate, time to peak strain, peak delay time in longitudinal, radial, circumferential directions in 16 left ventricular segments. The global peak systolic longitudinal and radial strain of left ventricle, peak systolic longitudinal strain and strain rate, diastolic strain rate of right ventricular free wall were also compared.Results(1) Global peak systolic longitudinal strain (GPSLS), peak systolic longitudinal strain (PSLS) and strain rate (PSLSR), peak early diastolic longitudinal strain rate (PELSR) in 16 segments were decreased in case (P < 0.05). (2) Peak systolic radial strain and strain rate of inferoseptum and inferolateral at the level of papillary muscle were lower (P < 0.05), and peak early diastolic radial strain rate (PERSR) was reduced (P < 0.05). (3) Peak early diastolic circumferential strain rate was lower (P < 0.05). (4) Time to peak systolic longitudinal, radial, circumferential strain was longer, and peak delay time at the same level retarded (P < 0.05). (5) Into right ventricular wall, PSLS and PSLSR at mid‐segment, and PSLSR, PELSR, peak atrial systolic longitudinal strain rate (PALSR) at basal were reduced (P < 0.05). (6) Inverse correlation between interventricular septum (IVS) thickness and GPSLS and GPSRS was found (P < 0.05).ConclusionSystolic and diastolic dysfunction existed in systemic amyloidosis with preserved EF. Mechanical contraction disorder may be one reason for systolic dysfunction. GPLSR and GPRSR were negatively related to IVS thickness.
Dental trauma in Brazilian children and adolescents with cerebral palsy
Authors: Cardoso Andreia Medeiros Rodrigues , Silva Clara Regina Duarte , Gomes Lays Nóbrega , Gomes Monalisa da Nóbrega Cesarino , Padilha Wilton Wilney Nascimento , Cavalcanti Alessandro Leite 
Published: June 2015

AbstractBackgroundAssessing the frequency and factors associated with dental trauma in pediatric populations with cerebral palsy is important for the planning and implementation of prevention and health promotion programs. The aim of this study was to determine the prevalence and factors associated with dental trauma in children and adolescents with cerebral palsy.Material and methodsCross‐sectional study with a non‐probabilistic sample of 80 patients aged 2–18 years was treated in a rehabilitation institution in northeastern Brazil. Caregivers completed a socioeconomic questionnaire, while oral exams were performed by a calibrated investigator (K = 0.75–1.00), with record of the Dental Trauma Index, DMFT and dmft, and Dental Aesthetics and malocclusion indices. Bivariate and multivariate Poisson regression analyses (α = 0.05) were performed with the Statistical Package for Social Sciences, version 17.ResultsThe prevalence of dental trauma was 36.3%, enamel fracture was the most common trauma (89.1%), and the upper central incisors were the most affected dental elements (63.0%). Patients with dental trauma were male, aged 7–18 years, with family income more than one minimum wage, caregiver's education over 4 years, increased overjet, lip hypotonia, quadriplegia, epilepsy, oral breathing, and severe communication skills. The presence of dental trauma was not associated with socioeconomic characteristics (gender, age, family income, and caregiver's educational level), oral health perception, and systemic and oral conditions (dental caries, malocclusion, and lip hypotonia) were evaluated (P > 0.05).ConclusionThe prevalence of dental trauma was high, but not associated with clinical variables and evaluated socioeconomic indicators.
A multicentre observational study for early diagnosis of Gaucher disease in patients with Splenomegaly and/or Thrombocytopenia
Authors: Motta Irene , Filocamo Mirella , Poggiali Erika , Stroppiano Marina , Dragani Alfredo , Consonni Dario , Barcellini Wilma , Gaidano Gianluca , Facchini Luca , Specchia Giorgina , Cappellini Maria Domenica ,   Splenomegaly Gaucher Disease study group
Published: June 2015

AbstractGaucher disease (GD) is the most common lysosomal disorder resulting from deficient activity of the β‐glucosidase enzyme that causes accumulation of glucosylceramide in the macrophage–monocyte system. Notably, because of non‐specific symptoms and a lack of awareness, patients with GD experience long diagnostic delays. The aim of this study was to apply a diagnostic algorithm to identify GD type 1 among adults subjects referred to Italian haematology outpatient units because of splenomegaly and/or thrombocytopenia and, eventually, to estimate the prevalence of GD in this selected population. One hundred and ninety‐six subjects (61 females, 135 males; mean age 47.8 ± 18.2 years) have been enrolled in the study and tested for β‐glucosidase enzyme activity on dried blood spot (DBS). Seven of 196 patients have been diagnosed with GD, (5 females and 2 males) with mean age 31.8 ± 8.2 years, with a prevalence of 3.6% (with a prevalence of 3.6% (I95% CI 1.4–7.2; 1/28 patients) in this population. These results show that the use of an appropriate diagnostic algorithm and a simple diagnostic method, such as DBS, are important tools to facilitate the diagnosis of a rare disease even for not disease‐expert physicians.
Forage yield and chemical composition of canola (Brassica napus L.) as affected by sowing methods
Authors: Reta‐Sánchez D. G. , Serrato‐Corona J. S. , Quiroga‐Garza H. M. , Gaytán‐Mascorro A. , Figueroa‐Viramontes U. 
Published: June 2015

AbstractThe sowing method of spring‐type canola (Brassica napus L. var. oleifera) for forage has a major influence on its productivity and agronomic management. A field experiment was conducted in Matamoros, Coahuila, Mexico, during two growing seasons (2008–2009 and 2009–2010) to determine dry matter (DM), crude protein (CP) and net energy for lactation (NEL) yields, as well as canola forage chemical composition as a function of six sowing methods. The treatments assessed were broadcast sowing and five different row spacings: 0·19, 0·38, 0·57, 0·76 and 0·95 m (double row, 0·20 m apart). In the first year, with a mean growing season temperature of 17·2°C, sowing methods did not affect DM yield, but CP and NEL content and yield were higher in 0·19‐m row spacing. The mean temperature in the second year (13·5°C) was slightly lower than the long‐term mean (14·8°C) in the region, resulting in the highest DM (8840 kg ha−1), CP (2486 kg ha−1) and NEL yields (51 103 MJ ha−1) with 0·19‐m row spacing. In row‐sowing methods with over 0·19‐m row spacing, DM, CP and NEL yields decreased by 19·3–39·7, 20·4–42·1 and 21·2–42·7% respectively. Results indicate that sowing methods significantly affected canola forage productivity.