bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial RNA cytosolic leakage drives the SASP
Authors: Victorelli Stella , Eppard Madeline , Woo Seung-Hwa , Everts Stacia , Martini Helene , Pirius Nicholas , Franco Ana Catarina , Han Yeaeun , Saul Dominik , Splinter Patrick , O'Hara Steven , Valenzuela-Pérez Lucia , Lee Hyun Se Kim , Jurk Diana , LaRusso Nicholas , Hirsova Petra , Passos Joao 
Published: August 2024

Abstract

Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (mtDNA) release and cGAS/STING pathway activation. Here, we demonstrate that mitochondrial RNA (mtRNA) also accumulates in the cytosol of senescent cells, activating RNA sensors RIG-I and MDA5, leading to MAVS aggregation and SASP induction. Inhibition of these RNA sensors significantly reduces SASP factors. Furthermore, BAX and BAK plays a key role in mtRNA leakage during senescence, and their deletion diminishes SASP expression in vitro and in a mouse model of Metabolic Dysfunction Associated Steatohepatitis (MASH). These findings highlight mtRNA's role in SASP regulation and its potential as a therapeutic target for mitigating age-related inflammation.
The impact of diclofenac suppositories on postcesarean section pain: a systematic literature review
Authors: Antwi Sara Agyemang , Antwi Prince Kwabena Agyemang , Adarkwa Samuel Akwasi , Mensah Kwesi Boadu , Woode Eric 
Published: August 2024

Abstract

Background:Managing postoperative pain after cesarean section is imperative, as acute postoperative pain is considered a risk factor for chronic postoperativepain. We investigatedthe role of diclofenac suppositories in postoperative pain management after cesarean section.Methods:For this systematic review, we searched PubMed, Scopus, the Cochrane Library, Google Scholar, and two other clinical trial registers from database inception up to July 23 to July 26, 2024. We included randomized controlled trials and other studies in whichdiclofenac suppositories were administeredas an intentional intervention. We excluded studies not reported in English and without a focus on the principal medicine (diclofenac suppository). Two researchers independently selected studies and evaluated the risk of bias with RoB-2 according to PRISMA-2020 guidelines. Primary outcomes included pain severity or intensity measured with validated clinical scales. We synthesized the studies narratively.Findings:From 203 records, we selected 16 studies. Discrepancies in the study design or its reporting were observed. The visual analogue scale (VAS) is a frequently used pain assessment tool. Diclofenac suppositories were compared under three broad categories: placebo, other nonsteroidalanti-inflammatory drugs (NSAIDs), opioids andopioid-like medicines. The combination of pain medicines (multimodal analgesia) was central to most ofthe studies; however, heterogeneity and risk of bias undermine the reliability of these findings.Interpretation:The combination of diclofenac suppositories with other NSAIDs, which are usually opioids such as morphine, meperidine or pentazocine, reduces the need for rescue pain medicines.
Hydatid Cyst involving the Biceps Brachii: A Singular Case Report of a Rare Intramuscular Affliction.
Authors: Purkayastha Debaraj Shome , Das Gautam , Mahanta Arup Kumar , Purkayastha Satakshi Shome 
Published: August 2024

Abstract

INTRODUCTION: Hydatid disease (HD) is an endemic zoonotic parasitic infection caused by Echinococcus granulosus. The incidence of HD in the musculoskeletal system and soft tissues is extremely rare, ranging from 0.5% to 4.7%.
CASE REPORT: We present a rare case of primary intramuscular hydatid disease in an agricultural worker, diagnosed through clinical evaluation, serological testing, and imaging, and managed with surgical intervention.
DISCUSSION: Hydatid disease is primarily transmitted through ingestion of eggs, leading to infection by the larval form of Echinococcus. While other transmission modes have been suggested, they lack strong evidence. Hydatid cysts most commonly affect the liver and lungs, but can rarely develop in muscles, which generally provide an unfavourable environment due to high lactic acid levels and muscle contractility. Intramuscular hydatid cysts, particularly in the upper limbs, are especially uncommon, likely due to constant muscle activity in this region.
Ultrasound, MRI, and serological tests are crucial diagnostic tools, with MRI being particularly useful for intramuscular cases. Surgical excision is the primary treatment, with pre- and post-operative anthelmintic therapy reducing recurrence rates.
CONCLUSION: Clinicians should maintain a high index of suspicion for hydatidosis in patients from endemic regions, particularly those with an agricultural background, when assessing musculoskeletal swellings. Early detection ensures timely management.
Hybrid modelling of nitrogen removal by biofiltration using high-frequent operational data
Authors: Serrao Marcello , Jauzein Vincent , Juran Ilan , Tassin Bruno , Vanrolleghem Peter 
Published: August 2024

ABSTRACT

In this research, a parallel hybrid model is presented for the simulation of nitrogen removal by submerged biofiltration of a very large-size wastewater treatment plant. This hybrid model combines a mechanistic and a machine learning model to produce accurate predictions of water quality variables. The models are calibrated and validated using detailed and quality-controlled operational data collected over a period of 3.5 months in 2020. The mechanistic model is a modified activated sludge model that describes the biological, physical and chemical processes taking place in a biofilm reactor based on the domain knowledge of these processes. A three-layer feed-forward artificial neural network with a rectified linear activation function that aims to reduce the mechanistic model's residual error and then correct its output. The results show how the hybrid model outperforms and significantly reduces the size of the mechanistic model's prediction errors of the effluent nitrate concentration from a relative mean error of 12% (mechanistic model) to 2% (hybrid model) during training. The error on nitrate simulations increases to 8% during hybrid model testing, still significantly lower than the error of the mechanistic model. These results support future operational applications of hybrid biofilm models, such as in digital twins.
A Comprehensive Review of the Factors and Strategies to Mitigate Construction Projects Delays in Saudi Arabia
Authors: Alshammari Adel , Ghazali Farid E. Mohamed 
Published: August 2024

Background
The construction industry in Saudi Arabia faces numerous challenges that hinder its progress due to frequent and prolonged project delays.

Objective
The specific objectives of this study are (1) (1) To analyze the factors contributing to construction project delays in Saudi Arabia, (2) To identify the risk of factors contributing to construction project delays, and (3) To propose strategies to mitigate construction project delays in Saudi Arabia.

Methods
The study reviewed 16 articles to identify and suggest solutions for construction project delays in Saudi Arabia.

Results
There are 140 factors of delay found and seven pose unacceptable risks including delays due to material delivery, delays in approval of submittals, design drawings, shop drawings, and sample materials (making decisions), delays related to subcontractors work, inflation and escalation of material prices (changes in price), lack of coordination with contractors, shortage of construction materials (non-availability of material), and equipment shortages. The risk assessment can be conducted using the Bowtie diagram, scenario analysis, MRM, and MCS separately or collectively to get a new and improved model.

Conclusion
This review will contribute to the development of strategies to enhance the performance of ongoing and future construction projects in the region. Additionally, decision-makers can utilize the outcomes to strategically allocate resources and improve construction project success.
Corpus Analysis Discourse Study (CADS): Diskusi “Klitih” melalui Media sosial Twitter Sebagai Ruang Publik Pada Tahun 2022 – 2023
Authors: Prabawati Lina Putri , Nurhidayah Siti , Elysa Sepriza 
Published: August 2024

Maraknya isu “Klitih” memang telah menjadi keresahan dan kegelisahan masyarakat di Yogyakarta, pasalnya kasus “Klitih” yang belakangan terjadi berkaitan dengan tindak penyimpangan seperti kekerasan dan penghilangan nyawa. Oleh karena itu, pada era digitalisasi seperti saat ini, sebagian besar masyarakat merepresentasikan kerasahan sekaligus aspirasinya pada media sosial salah satunya melalui Twitter atau yang saat ini disebut dengan X. Pada dasarnya tujuan atau fokus dari studi ini adalah untuk mengetahui perkembangan isu tentang “Klitih” yang terjadi di Yogyakarta yang dilihat melalui diskusi masyarakat pada media sosial Twitter atau X. Studi akan mengidentifikasi mengenai tanggapan masyarakat terkait kasus “Klitih” di Yogyakarta sebagai bentuk dari advokasi digital yang dilakukan melalui media sosial khususnya Twitter. Metode analisis data dilakukan menggunakan Corpus-Assisted Discourse Study (CADS) dengan menganalisis data cuitan atau tweet pada Twitter. Proses pengumpulan data diperoleh melalui scraping Twitter dengan menggunakan kata kunci terkait “Klitih”. Hasil menunjukkan bahwa terdapat tiga wacana dominan yang muncul dalam diskusi atau pembahasan masyarakat mengenai kasus “Klitih” pada media Twitter, yaitu Pariwisata; Stakeholder dan Respon Masyarakat. Diskusi masyarakat yang terungkap memberikan pemahaman tentang kekhawatiran dan aspirasi yang perlu diperhatikan dalam penanganan “ Klitih” di Yogyakarta melalui proses kerjasama antar stakeholder yang meliputi pihak kepolisian dan juga pemerintah.
Satiety and glycemic control after giving glucomannan-modified growol cookies
Authors: Puspaningtyas Desty Ervira , Sucipto Adi , Styaningrum Silvia Dewi , Sari Puspita Mardika , Nidyarini Anita , Rahmawati Dwita Mukti , Lestari Getha Puji , Sintia Renata Deby , Ananda Dhea Putri 
Published: August 2024

<p><strong><em>Background: </em></strong><em>Obesity has become an epidemic in all parts of the world.</em> One in five deaths is related to obesity predisposition. Providing foods high in fiber can be a solution to treating obesity. The addition of glucomannan to growol cookies can optimize the fiber content of food which will have an effect in controlling satiety and glycemic control.</p><p><strong><em>Objective: </em></strong><em>T</em><em>o study the effect of glucomannan-modified </em><em>g</em><em>rowol cookies</em><em>, </em><em>as a healthy </em><em>snack</em><em> in the context of preventing obesity</em><em>, </em><em>on changes in satiety and blood glucose levels in </em><em>excessive-weight</em><em> subjects </em><em>(ES) </em><em>and normal</em><em>-weight </em><em>subjects</em><em> (NS)</em>.</p><p><strong><em>Methods: </em></strong><em>A quasi-experimental study with a pre-post design without a control group was conducted on 30 subjects (15 NS and 15 ES). The research was carried out at Universitas Respati Yogyakarta in June-July 2023. The satiety test was carried out using the SLIM (Satiety Labeled Intensity Magnitude) method. Blood glucose levels were measured using the Rapid Test method using Easy Touch GCU before, immediately after, and 120 minutes after giving cookies. Data on satiety and blood glucose levels were sequentially analyzed using the Wilcoxon Signed Ranks Test and Paired Samples T Test (comparing before and after intervention) as well as the Mann-Whitney U Test and Independent Samples T Test (comparing between groups) with a significance of 95%.</em><em></em></p><p><strong><em>Results: </em></strong><em>There was a difference in the feeling of fullness between the 0th minute, 30th minute, 60th minute, and 90th minute compared to the initial feeling of fullness (basal) in the entire group (p&lt;0.05)</em><em>.</em><em> </em><em>There was no difference in blood glucose levels between fasting blood glucose, 0-minute blood glucose, and 120-minute blood glucose</em><em>. G</em><em>lucomannan-modified </em><em>g</em><em>rowol cookies can delay hunger for 1-1.5 hours before the next big meal. </em><em>G</em><em>lucomannan-modified </em><em>g</em><em>rowol cookies can </em><em>also </em><em>maintain blood glucose stability in the range of 90 mg/dL.</em></p><strong><em>Conclusion: </em></strong><em>Glucomannan-modified growol cookies can have a positive effect on satiety control and glycemic control</em><em>.</em>
Pendampingan Kader Posyandu pada Pelaksanaan Program Investigasi Kontak Erat Pasien Tuberkulosis Paru di Wilayah Kerja Puskesmas Margahayu Raya Kota Bandung
Authors: Triyani Yani , Achmad Sadiah , Ekowati RA Retno 
Published: August 2024

<p><em>Berdasarkan hasil survey tahun 2022 cakupan penemuan pasien baru penderita Tuberkulosis (TB) hanya 52,6%. Pengabdian ini <strong>bertujuan</strong> melakukan pelatihan kader posyandu tentang investigasi kontak erat dan dampak buruk keluarga sebagai penular atau yang tertular TB dapat segera ditangani dengan baik. <strong>Metode pelaksanaan</strong> PKM ini terdiri dari 3 tahap, ke-1 dengan metode talk show interaktif tentang program kontak erat pasien TB, dengan sebelum dan sesudah tahap-1 dilakukan pre dan post tes. Tahap ke-2 dilakukan analisis data hasil pre test dan post test. Tahap ke-3 dilakukan pendampingan langsung di lapangan saat pelaksanaan posyandu. <strong>Hasil PKM</strong> adalah tersosialisasikannya definisi, alur pelaporan dan tindak lanjutnya kontak erat pasien TB kepada para kader posyandu. Terjadi peningkatan pengetahuan para kader kesehatan tentang investigasi kontak erat yang terlihat dari peningkatan skor minimun 10 menjadi 60, dan skor maksimun dari 90 menjadi 100 dari nilai pre test dan post test. Berhasil dilakukan penjaringan terhadap 13 anak dan 22 orang dewasa dari 4 pasien baru TB, dan ditemukan 1 orang anak positif dengan tes Mantoux dan 1 orang dewasa yang positif dengan pemeriksaan dahak menggunakan tes cepat molekuler TB. Kesimpulan kegiatan ini akan dapat membantu dalam penemuan dini pasien baru TB sehingga pengobatan bisa lebih cepat dan mencegah penularan lebih lanjut.</em></p>
Using Digital Media to Improve Adolescent Resilience and Prevent Mental Health Problems: Protocol for a Scoping Review
Authors: Rachmayanti Riris D , Dewi Fatwa Sari Tetra , Setiyawati Diana , Megatsari Hario , Diana Rian , Vinarti Retno 
Published: August 2024

Background
Global databases show a high prevalence of mental health problems among adolescents (13.5% among those aged 10-14 years and 14.65% for those aged 15-19 years). Successful coping depends on risk and protective factors and how their interaction influences resilience. Higher resilience has been shown to correlate with fewer mental health problems. Digital mental health interventions may help address these problems.

Objective
This protocol serves as a framework for planning a scoping review to map the types of digital communication media and their effectiveness in increasing resilience in youths.

Methods
The Joanna Briggs Institute guidelines will be used: defining the research questions; identifying relevant studies; study selection (we will select articles based on titles and abstracts); charting the data; collating, summarizing, and reporting the results; and consultation. The synthesis will focus on the type of digital media used to increase adolescent resilience skills and the impact they have on adolescent resilience skills. Quantitative and qualitative analyses will be conducted.

Results
The study selection based on keywords was completed in December 2023, the study screening and review were completed in February 2024, and the results manuscript is currently being prepared. This scoping review protocol was funded by the Center for Higher Education Funding and the Indonesia Endowment Fund for Education.

Conclusions
The results of the study will provide a comprehensive overview of commonly used digital media types and their effectiveness in increasing youth resilience. Thus, the results of this scoping review protocol can serve as foundational evidence in deciding further research or interventions. This study may also be used as a guideline for mapping and identifying the type and impact of communication media used to increase adolescents’ resilience skills.

International Registered Report Identifier (IRRID)
DERR1-10.2196/58681
Survei Standarisasi Sarana dan Prasarana Olahraga di Kecamatan Kuala Jambi Kabupaten Tanjung Jabung Timur
Authors: Efendi Faisal , Hadinata Reza , Adrizal Mohd. 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui standarisasi sarana dan prasarana olahraga di Kecamatan Kuala Jambi. Penelitian ini merupakan penelitian kualitatif dengan metode survei. Sumber data yang akan diperoleh dari pengurus gedung dan pemain yang menjelaskan mengenai jumlah, kondisi sarana dan prasarana pendidikan jasmani. Teknik pengumpulan data dengan wawancara. dokumentasi dan lembar observasi, analisis data menggunakan analisis kualitatif. Hasil penelitian menunjukkan bahwa sarana dan prasarana untuk cabang sepak bola di Kecamatan Kuala Jambi terdapat banyak sekali sarana dan prasarana tidak standar, sementara hanya beberapa sarana dan prasarana tergolong standar seperti lebar tiang gawang, bola sepak, dan drainase yang ada di lapangan sepak bola teluk majelis yang berkategori standar. Untuk sarana dan prasarana Bulutangkis terdapat 14 sarana dan prasarana tidak standar sedangkan hanya terdapat 12 sarana dan prasarana yang standar. Untuk sarana dan prasarana cabang bola voli terdapat 8 sarana dan prasarana tergolong tidak standar, sedangkan hanya terdapat 1 sarana dan prasarana yang standar. Untuk cabang Futsal terdapat 3 sarana dan prasarana tergolong tidak standar sedangkan 8 sarana dan prasarana yang standar. Akan tetapi untuk jumlah sarana dan prasarana olahraga yang ada di kecamatan kuala jambi tergolong sangat minim dimana ada beberapa desa yang tidak memiliki sarana dan prasarana olahraga seperti Desa Kuala Lagan, Desa Manunggal Makmur, dan Kelurahan Tanjung Solok
Escalating the Tourist Revisit Intention on the Heritage Destination with the Memorable Tourism Experiences
Authors: Saryatun Saryatun , Riptiono Sulis , Nur Azizah Siti , Muliana Rhamdhani Intan 
Published: August 2024

Objectives: The objective of this research is to investigate the tourists' revisit intention at heritage destinations by testing memorable tourism experiences, destination image, and tourist satisfaction as predictors.Methodology: The heritage destination studied was the Borobudur temple involving a sample of 330 tourists taken using a convenience sampling technique. Data were processed and analyzed using SEM-AMOS.Finding: The results of this research prove that not all components of memorable experience are proven to be significant on destination image, satisfaction, and revisit intention. Destination image can be predicted by the variable’s novelty, local culture, meaningfulness, involvement, and knowledge, while hedonism is not significant. Satisfaction can be predicted by hedonism, novelty, refreshment, meaningfulness, knowledge, and destination image, while local culture and involvement are not significant. Revisit intention is predicted by novelty, local culture, involvement, knowledge, and satisfaction, while hedonism, refreshment, meaningfulness, and destination image are not significant.Conclusion: findings from this research show that local culture is the dominant variable in determining destination image, and novelty is the antecedent that has the greatest influence on satisfaction and revisit intention at heritage destinations.
Desarrollo de manual de procesos y procedimientos en una entidad pública en el marco del MIPG.
Authors: Ramírez-Arias Carlos Andres 
Published: August 2024

El desarrollo de este proyecto de grado tiene como propósito brindar una propuesta soportada en el marco normativo del Modelo Integrado de Planeación y Gestión MPIG, acompañado de las políticas de calidad estipuladas por el modelo gestión de calidad ISO 9001, enmarcando la importancia que tiene el aseguramiento de la calidad en las instituciones públicas por medio de los lineamientos planteados en la guía para la gestión por proceso, en el marco del modelo integrado de planeación y gestión el cual entrega las herramientas fundamentales para darle estandarización a todas las actividades realizadas dentro de las oficinas de todos los entes pertenecientes al rol público. El objetivo general de la investigación es la formulación de un manual de procesos y procedimientos proyectado para el área de recuperación de cartera del municipio de San José de Cúcuta, que busca el fortalecimiento del manejo de actividades y procesos en la entidad, estableciendo previamente en un documento estandarizado en pro del correcto flujo de acciones llevadas a cabo en esta oficina, para el cumplimiento de este objetivo se realizará un diagnóstico del sector por medio de las herramientas brindadas en la metodología cualitativa logrando así la base para la caracterización y posterior a esto la formulación de los procesos y procedimientos.
THE ACTUALIZATION OF RELIGIOUS AND CULTURAL VALUES AS A CONTROLLING FACTOR FOR THE SOCIAL EFFECTS OF TERRORISM
Authors: Nisbah  , Jamaluddin  , Jamaluddin  , Abdul Hakim  
Published: August 2024

This study aims to determine the extent to which religious and cultural values in the Lembantongoa Village community strengthen their social group identity, as well as the source of ideas, thoughts, ways, which are useful as a barrier and inhibiting factor for the creation of destructive social turmoil effects due to the terrorist movement.
The results of this study reveal facts that explain 1) the influence of religion and culture is still quite strong, manifested in community behavior in the form of
adherence to customary norms; life cycle ceremonies, customary laws, social organizations, always strengthen their structural and cultural identity, 2) the real act of murder terror in Lembantongoa Village is an attempt to manipulate the power of religion and culture as a means of justifying social turmoil, 3) the perpetrators of terror are the continuity of terrorist actors " MIT Theorist Group in Poso" , trying to create " Social Turmoil" in Sigi Regency streotype of conflict and social unrest in Poso, 4) overcoming the consequences and problems of murder terror, should critically address the failure of terrorist groups to utilize religion and custom as a trigger for Social Turmoil.