bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case of cephalothoracopagus conjoined twinning in an embryonic mouse
Authors: Hynd Thomas E. , Buckley Cadie L. , Lozanoff Scott 
Published: June 2013

BACKGROUNDCephalothoracopagus twinning is extremely rare, and it is characterized by fusion of the head and thorax, two separate spines, pelves, and fore‐ and hindlimbs. CASE: In this case study, we describe cephalothoracopagus twinning in an embryonic mouse displaying a large but exencephalic head, median facial cleft, a single eye, and a second hindbrain rotated roughly 90° from a second spinal cord. There is a bony connection joining the clavicles, resulting in merged asternal thoracic cavities containing two hearts and four lungs. The abdominal cavities contain double caudal digestive tract structures, but a single esophagus and stomach.CONCLUSIONThere are several proposed theories regarding the mechanism of spontaneous conjoined twinning; however, the specific mechanisms are still largely unknown. In this report, we highlight the morphological features in a murine example of cephalothoracopagus twinning, furthering our understanding of this rare occurrence while also demonstrating developmental morphogenesis consistent with that reported for human conjoined twins. Birth Defects Research (Part A) 97:421–424, 2013. © 2013 Wiley Periodicals, Inc.
Association between PTCH1 polymorphisms and risk of neural tube defects in a Chinese population
Authors: Wang Zhen , Wang Li , Shangguan Shaofang , Lu Xiaolin , Chang Shaoyan , Wang Jianhua , Zou Jizhen , Wu Lihua , Zhang Ting , Luo Yi 
Published: June 2013

BACKGROUNDSHH signaling pathway plays an important role in the formation of the neural plate and is involved in the regulation of the dorsoventral (DV) axis of the neural tube. Some neural tube defects (NTDs) may be caused through overactivation of the SHH signaling pathway. The PTCH1 gene, encoding a negative regulator of SHH signaling, affects neural tube closure in animal models. However, in humans, the relationship between single nucleotide polymorphisms (SNPs) of the PTCH1 gene and neural tube defects remains unclear.METHODSMassARRAY®GENOTYPER™ was used to genotype 18 SNPs of the PTCH1 gene in 187 NTDs and 212 control samples, to determine whether PTCH1 polymorphisms are related to NTDs. MassARRAY®EpiTYPER™ was performed to assess whether methylation modifications may be associated with SNP genotypes in this Chinese population.RESULTIncreased risk for spina bifida was observed with the G allele of c.3944C>T and the T allele of c.1729™2350G>A in female patients when compared to the normal control group. High methylation levels were detected in those controls bearing the G allele of c.3944C>T.ConclusionIn summary, polymorphisms of the PTCH1 gene may be genetic predisposing factors for spina bifida in the population studied. In addition, methylation modifications associated with the c.3944C>T polymorphism, may provide protection. Birth Defects Research (Part A) 97:409–415, 2013. © 2013 Wiley Periodicals, Inc.
Photoinduced oxidation of a tris(2,2'‐bipyridyl)ruthenium(II)–peroxodisulfate chemiluminescence system for the analysis of mebeverine HCl pharmaceutical formulations and biological fluids using a two‐chip device
Authors: Lawati Haider A. J. Al , Dahmani Zeiyana M. Al , Varma Gouri B , Suliman FakhrEldin O 
Published: June 2013

ABSTRACTA new method for the analysis of mebeverine hydrochloride (MEB) has been developed using a two‐chip device. The method is highly selective, sensitive, rapid and consumes minute amount of reagents. The developed method is free of interference from the degradation products of MEB and from common ingredients present in pharmaceutical formulations. The limit of detection was 0.043 µg/mL, and the limit of quantification was 0.138 µg/mL. The short analysis time per sample (20 s) allowed a large number of analyses to be performed within a very short time. Various samples were analyzed, including two different pharmaceutical formulations and a uniformity of content analysis for 20 tablets from a known batch and two biological samples at different concentrations. In addition, the method was compared with a validated high‐performance liquid chromatography (HPLC) method and the results clearly indicated the suitability of the developed method for routine analyses. A new mechanism for the tris(2,2'‐bipyridyl)ruthenium(II) (Ru(bpy)32+)‐peroxodisulfate (S2O82−) chemiluminescence (CL) system has also been proposed. The mechanism is based on photoinduced oxidation of Ru(bpy)32+ to Ru(bpy)33+ via the formation of Ru(bpy)32+* upon irradiation with visible light. S2O82− then oxidizes Ru(bpy)32+* to Ru(bpy)33+ and the analyte subsequently reduces the resultant Ru(bpy)33+ to Ru(bpy)32+*, which then produces the CL signal. Copyright © 2013 John Wiley & Sons, Ltd.
Physical chemistry of nucleic acids and their complexes
Authors: Ghirlando Rodolfo , Felsenfeld Gary 
Published: June 2013

ABSTRACTStudies of the physical properties of nucleic acids began almost immediately following the discovery of the DNA structure. Early investigations focused on the stability and specificity of multi‐strand polynucleotide complexes, then gradually on their interaction with other molecules, particularly proteins. As molecular and structural biology expanded to provide detailed information about biochemical mechanisms, physical studies eventually acquired the additional constraint that they should be relevant to functioning biological systems. We describe work in our laboratory that began with investigations of relatively simple questions about the role of electrostatic interactions in the stabilization of multi‐strand nucleic acid structures, and evolved to studies of chromatin structure in vitro and within the nucleus. Published 2013 Wiley Periodicals, Inc*. Biopolymers 99: 910–915, 2013.
Mucin‐Type Glycopeptide Structure in Solution: Past, Present, and Future
Authors: Barchi Joseph J. 
Published: June 2013

ABSTRACTMucins are very high molecular weight glycoproteins that form a “mucus” barrier at the surface of epithelial cells. They are heavily glycosylated with O‐linked glycans that are involved in myriad cellular functions, including protection from external changes in pH, ion flux and reactive oxygen species. Aberrations in mucin expression and their glycan constitution have been associated with many disease states including gastritis, pulmonary disorders and cancer. High resolution structural information on mucins is lacking due to their complexity, in particular their large size and the many variants of O‐linked glycans produced in their biosynthesis. This review discusses the structures of glycopeptides that contain “mucin‐type” glycosylation, and concentrates primarily on data obtained by NMR spectroscopy. The effect of the glycan on the peptide backbone, the features that have shown to be common to this type of glycosylation and the differences of glycosylation at serine and threonine residues are the major topics of discussion. Published 2013 Wiley Periodicals, Inc. Biopolymers 99: 713–723, 2013.
Rearranging RNA structures at 75°C? toward the molecular mechanism and physiological function of the thermus thermophilus DEAD‐box helicase hera
Authors: Klostermeier Dagmar 
Published: June 2013

ABSTRACTDEAD‐box helicases catalyze the ATP‐dependent destabilization of RNA duplexes. Hera is a DEAD‐box helicase from Thermus thermophilus that consists of a helicase core, followed by a C‐terminal extension comprising a dimerization domain and an RNA‐binding domain. The combined structural information on individual Hera domains provides a molecular model of the Hera dimer. The modular architecture with flexible connections between individual domains affords different relative orientations of the RBD relative to the Hera helicase core, and of the two helicase cores within the dimer. Presumably, domain movements are intimately linked to RNA binding, to the interplay of the RBD and the helicase core, and to RNA unwinding, and may impact on the functional cooperation of the two helicase cores in RNA unwinding. The in vivo function of Hera is unknown. The Hera RBD recognizes two distinct elements in the RNA substrate, a single‐stranded and a structured region. The helicase core then unwinds an adjacent RNA duplex in an ATP‐dependent reaction. Overall, this mode of action is reminiscent of DEAD‐box proteins that act as general RNA chaperones. This review summarizes the current knowledge on Hera structure and function, and discusses a possible role of Hera in the Thermus thermophilus cold‐shock response. © 2013 Wiley Periodicals, Inc. Biopolymers 99: 1137–1146, 2013.
Profiling and identification of the absorbed constituents and metabolites of schisandra lignans by ultra‐performance liquid chromatography coupled to mass spectrometry
Authors: Sun Hui , Wu Fangfang , Zhang Aihua , Wei Wenfeng , Han Ying , Wang Xijun 
Published: June 2013

ABSTRACTSchisandra chinensis Baill grows wild in Russia, China, Korea and Japan, and its fruit has been found to be effective in amnesia and insomnia. It is enriched in schisandra lignans (SL) that are major components responsible for therapeutic action. However, there are no reports on the biotransformation analysis of SL. An ultra‐performance liquid chromatography/electrospray‐ionization high‐definition mass spectrometry (UPLC‐Q‐TOF‐HDMS) method was developed to investigate the metabolism of SL in vivo. MS was performed on a Waters Micromass high‐definition system with an electrospray ionization source in positive ion mode and automated MetaboLynx software analysis with excellent MS accuracy and enhanced MS data acquisition. An improved mass defect filter (MDF) method employing both drug and core structure filter templates was applied to the processing of UPLC‐Q‐TOF‐HDMS data for the detection and structural characterization of metabolites. In this study, 30 metabolites were detected and identified in vivo, and demethylation and hydroxylation were confirmed as the primacy metabolic pathway for SL in rat plasma. In conclusion, the presently developed methodology was suitable for biotransformation research of SL and will find wide use in metabolic studies for other herbal medicines. Copyright © 2013 John Wiley & Sons, Ltd.
Functional and morphological assessment of side branch after left main coronary artery bifurcation stenting with cross‐over technique
Authors: Kang Soo‐Jin , Ahn Jung‐Min , Kim Won‐Jang , Lee Jong‐Young , Park Duk‐Woo , Lee Seung‐Whan , Kim Young‐Hak , Lee Cheol Whan , Park Seong‐Wook , Park Seung‐Jung 
Published: June 2013

BackgroundIn left main coronary artery (LMCA) bifurcation lesions, hemodynamic and geometrical change in left circumflex artery (LCX) ostium after main branch (MB) stenting has not been known. This study evaluated how accurately intravascular ultrasound (IVUS) predicts the functional compromise of the sidebranch.MethodsA single‐stent cross‐over technique was used to treat LMCA bifurcation lesions in 43 patients with LCX ostial diameter stenosis (DS) of <50%. The fractional flow reserve (FFR) in the LCX was measured after MB stenting, MB and sidebranch pullback IVUS was performed prestenting and poststenting.ResultsAfter MB stenting, angiographic DS >50% at the LCX ostium was observed in 18 (42%) patients, while only 3 (7%) showed FFR <0.80. A pre‐procedural minimal lumen area (MLA) of <3.7 mm2 within the LCX ostium was predictive of a poststenting FFR <0.80, with a sensitivity of 100%, specificity of 71%, a positive predictive value (PPV) of 16%, and a negative predictive value (NPV) of 100% (area under curve 0.80, P < 0.001). Moreover, pre‐procedural plaque burden of >56% at the LCX ostium predicted FFR <0.80, with a sensitivity of 100%, specificity of 65%, a PPV of 14%, and a NPV of 100% (area under curve 0.80, P < 0.001). A poststenting LCX ostial DS >57% predicted FFR <0.80 with a sensitivity of 100%, specificity of 88%, a PPV of 38% and a NPV of 100% (area under curve 0.962, P < 0.001). However, the poststenting MLA within the LCX ostium showed no significant correlation with FFR (r = 0.197, P = 0.391).ConclusionsIn LMCA bifurcation lesions with mild LCX ostial disease, the use of single‐stent technique rarely resulted in the functional LCX compromise. Because the functional LCX stenosis is poorly predicted by a small MLA, sidebranch treatment should be based on the poststenting FFR. © 2013 Wiley Periodicals, Inc.
Pediatric patient radiation dosage during endomyocardial biopsies and right heart catheterization using a standard “ALARA” radiation reduction protocol in the modern fluoroscopic Era
Authors: Sutton Nicole J. , Lamour Jacqueline , Gellis Laura A. , Pass Robert H. 
Published: June 2013

BackgroundSurveillance endomyocardial biopsy (EMB) with right heart catheterization (RHC) is the standard of care for the assessment of post cardiac transplantation rejection. This procedure has traditionally relied upon fluoroscopy, which exposes both patient and staff to the risks of ionizing radiation. These risks may be of particular concern in the transplant patient who must undergo many such procedures lifelong. We present data on a new “ALARA – As Low As Reasonably Achievable” protocol to reduce radiation exposure during the performance of RHC with EMB.MethodsAll cardiac transplantation patients < 21 years of age who underwent RHC with EMB at The Children's Hospital at Montefiore from 6/11–12/11 were included. EMB was performed after all right heart pressures including wedge pressure and thermodilution cardiac output were measured. A novel ALARA protocol consisting of multiple features including ultra‐low frame rates (2–3 fps), low fluoro dose/frame (10–18 nGy/frame), use of the “air‐gap” technique for patients < 20 kg, and multiple other techniques aimed at minimizing use of fluoroscopy were employed in all cases. Demographics, procedural data and patient radiation exposure levels were collected and analyzed.Results18 patients underwent 45 surveillance RHC with EMB in the study period and were the subject of this analysis. The mean age was 5.9 ± 6.1 years, weight was 20.4 kg ± 16.6 kg, and BSA was 0.75 ± 45 m2. PA fluoroscopy was used exclusively in 45/45. Vascular access was RFV (21/45; 47%), RIJV (17/45; 38%), LFV (4/45; 9%) and LIJV (3/45; 7%). The median number of EMB specimens obtained was 5 (range, 4–7). The median fluoroscopy time was 3.7 min (range, 1.2–9). The median air Kerma product (K) was 1.4 mGy (range, 0.4–14), and dose area product (DAP) was 15.8 uGym2 (range, 3.5–144.5). The K and DAP are substantially lower than any prior published data for RHC/EMB in this patient group. There were no procedural complications.ConclusionsThe use of a novel ALARA protocol for RHC and EMB in pediatric cardiac transplantation patients markedly reduced radiation exposure to levels far below any previously reported values without negatively affecting the safety or efficacy of these procedures. © 2013 Wiley Periodicals, Inc.
Elementary Photoelectronic Processes at a Porphyrin Dye/Single‐Walled TiO2 Nanotube Hetero‐interface in Dye‐Sensitized Solar Cells: A First‐Principles Study
Authors: Dong Cunku , Li Xin , Zhao Wei , Jin Pengfei , Fan Xiujuan , Qi Jingyao 
Published: June 2013

AbstractA unique one‐dimensional (1D) sandwich single‐walled TiO2 nanotube (STNT) is proposed as a photoanode nanomaterial with perfect morphology and large specific surface area. We have thoroughly examined the elementary photoelectronic processes occurring at the porphyrin dye/STNT hetero‐interface in dye‐sensitized solar cells (DSSCs) by theoretical simulation. It is desirable to investigate the interfacial photoelectronic processes to elucidate the electron transfer and transport mechanism in 1D STNT‐based DSSCs. We have found that the photoexcitation and interfacial charge separation mechanism can be described as follows. A ground‐state electron of the dye molecule (localized around the electron donor) is first promoted to the excited state (distributed electron donor), and then undergoes ultrafast injection into the conduction band of the STNT, leaving a hole around the oxidized dye. Significantly, the injected electron in the conduction band is transported along the STNT by means of Ti 3d orbitals, offering a unidirectional electron pathway toward the electrode for massive collection without the observation of trap states. Our study not only provides theoretical guidelines for the modification of TiO2 nanotubes as a photoanode material, but also opens a new perspective for the development of a novel class of TiO2 nanotubes with high power‐generation efficiency.
ChemInform Abstract: Site Preference and Ordering Induced by Au Substitution in the γ‐Brass Related Complex Au—Cr—Zn Phases.
Authors: Jana Partha P. , Henderson Ryan , Harbrecht Bernd , Lidin Sven 
Published: June 2013

AbstractA series of samples of (AuxCr1‐x)Zn≈17 (0.02 ≤ x ≤ 0.1) is prepared by solid state reaction of the elements (fused silica ampules, argon; 1.
ChemInform Abstract: A Novel Composite Material Based on Antimony(III) Oxide and Amorphous Silica.
Authors: Zemnukhova Ludmila , Panasenko Alexander E. 
Published: June 2013

AbstractThe composite material nSb2O3·mSiO2·xH2O is prepared by hydrolysis of SbCl3 dissolved in aqueous HCl and Na2SiO3 dissolved in aqueous NaOH.
ChemInform Abstract: Solid Solution Studies of Layered Honeycomb‐Ordered Phases O3—Na3M2SbO6 (M: Cu, Mg, Ni, Zn).
Authors: Schmidt Whitney , Berthelot Romain , Sleight A. W. , Subramanian M. A. 
Published: June 2013

AbstractComplete solid solutions Na3M12‐xM2x SbO6 (M1, M2: Cu, Mg, Ni, Zn) are characterized by XRD, magnetic susceptibility, and optical measurements.
ChemInform Abstract: Synthesis, Crystal Structure, and Variable‐Temperature‐Luminescent Property of the Organically Templated Pentaborate [C10N2H9] [B5O6(OH)4] ·H3BO3·H2O.
Authors: Yang Yang , Fu DongSheng , Li GuoFa , Zhang Yun 
Published: June 2013

AbstractColorless block crystals of the title compound are prepared by addition of boric acid to a solution of 4,4′‐bipyridine in water (90 °C, 68% yield).
ChemInform Abstract: Synthesis of Complex Polymeric Telluridoindates from KlnTe2.
Authors: Heine Johanna , Santner Silke , Dehnen Stefanie 
Published: June 2013

AbstractThe structures of the four new telluridoindates (II) (monoclinic, space group C2/c, Z = 4), (III) (monoclinic, P21/c, Z = 4), (IV) (triclinic, P$\bar 1$, Z = 2), and (V) (tetragonal, I$\bar 4$m2, Z = 4) are determined by single crystal XRD.
ChemInform Abstract: Chitosan: A Highly Efficient Renewable and Recoverable Bio‐polymer Catalyst for the Expeditious Synthesis of α‐Amino Nitriles and Imines under Mild Conditions.
Authors: Dekamin Mohammad G. , Azimoshan Mojtaba , Ramezani Leila 
Published: June 2013

AbstractChitosan is shown to be an efficient recoverable catalyst for the synthesis of α‐amino nitriles (IV) and imines (VII).
ChemInform Abstract: Multimetallic Ir—Sn3‐Catalyzed Substituted Reaction of π‐Activated Alcohols with Carbon and Heteroatom Nucleophiles.
Authors: Maity Arnab Kumar , Chatterjee Paresh Nath , Roy Sujit 
Published: June 2013

AbstractAn atom economic and catalytic substitution reaction of π‐activated benzyl, allyl, and propargyl alcohols by the multimetallic title complex is presented.
ChemInform Abstract: Aerobic Oxidative Deprotection of Benzyl‐Type Ethers under Atmospheric Pressure Catalyzed by 2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)/tert‐Butyl Nitrite.
Authors: Shen Zhenlu , Sheng Lili , Zhang Xiaochu , Mo Weimin , Hu Baoxiang , Sun Nan , Hu Xinquan 
Published: June 2013

AbstractOptimized conditions are developed which allow the deprotection of various ‐Pmb, ‐Ppb and ‐Bn ethers with complete conversion and selectivity.
ChemInform Abstract: Tribromoisocyanuric Acid in Trifluoroacetic Acid: An Efficient System for Smooth Brominating of Moderately Deactivated Arenes.
Authors: de Almeida Leonardo S. , de Mattos Marcio C. S. , Esteves Pierre M. 
Published: June 2013

AbstractTFA as the medium avoids polybromination which is observed for the same reaction in concentrated sulfuric acid.
ChemInform Abstract: Room‐Temperature Ullmann‐type C—O and C—S Cross‐Coupling of Aryl Halides with Phenol/Thiophenol Catalyzed by CuO Nanoparticles.
Authors: Babu S. Ganesh , Karvembu R. 
Published: June 2013

AbstractAdvantages are the use of a heterogeneous, reusable catalyst and ligand‐free conditions.
ChemInform Abstract: Catalytic Aerobic Photooxidative Cleavage of Carbon—Carbon Triple Bonds Using Carbon Tetrabromide.
Authors: Yamaguchi Tomoaki , Nobuta Tomoya , Kudo Yasuhisa , Hirashima Shin‐ichi , Tada Norihiro , Miura Tsuyoshi , Itoh Akichika 
Published: June 2013

AbstractOptimized conditions including water as an additive allow the cleavage of terminal and internal alkynes to carboxylic acids.
ChemInform Abstract: Organocatalytic Solvent‐Free Hydrogen Bonding‐Mediated Asymmetric Michael Additions under Ball Milling Conditions.
Authors: Joerres Manuel , Mersmann Stefanie , Raabe Gerhard , Bolm Carsten 
Published: June 2013

AbstractThe use of chiral thioureas as catalysts for the solvent‐free anti‐selective Michael reaction of 2‐nitrocyclohexan‐1‐one and nitrovinyl compounds under ball milling is described.
ChemInform Abstract: Phenoxide‐Mediated Sonogashira Coupling of Trimethylsilylalkynes and Aryl Iodides: Practical Synthesis of Phenolic‐Hydroxy‐Substituted Diarylethynes and 1,4‐Diarylbutadiynes.
Authors: Shigeta Masayuki , Watanabe Junji , Konishi Gen‐ichi 
Published: June 2013

AbstractThe reaction becomes possible by a silyl group migration induced deprotection of alkynes, in which the phenol moiety of the substrate works as a desilylating agent.
ChemInform Abstract: Extraordinary Microwave Effect on atropo‐Enantioselective Catalytic Reduction of Biaryl Lactones.
Authors: Nushiro Kazuya , Kikuchi Satoshi , Yamada Tohru 
Published: June 2013

AbstractThe catalytic atropo‐enantioselective Corey—Bakshi—Shibata reduction of biaryl lactones such as (I) and (III) is drastically enhanced under microwave conditions, while high enantioselectivity is maintained.
ChemInform Abstract: Asymmetric 5‐endo Chloroetherification of Homoallylic Alcohols Toward the Synthesis of Chiral β‐Chlorotetrahydrofurans
Authors: Zeng Xianghua , Miao Chengxia , Wang Shoufeng , Xia Chungu , Sun Wei 
Published: June 2013

Abstractusing an easily available quaternary ammonium salt derived from cinchonine as organocatalyst
ChemInform Abstract: Synthesis and Antimicrobial Activity of 2‐(Pyridine‐3‐yl)‐4H‐chromen‐4‐one Derivatives.
Authors: Chate Asha V. , Ghotekar Dattatraya S. , Bhagat Sunil S. , Gill Charansingh H. 
Published: June 2013

AbstractThe novel title compounds (II) are synthesized by a simple and environmentally friendly method.
ChemInform Abstract: Synthesis of 5‐Substituted 8,8‐Dimethyl‐8,9‐dihydro‐3H,7H‐[1,2]oxazino[5,4,3‐de]quinolin‐3‐ones.
Authors: Rudenko D. A. , Slepukhin P. A. , Karmanov V. I. , Shurov S. N. , Vakhrin M. I. , Shchurov Yu. A. 
Published: June 2013

Abstract6 Title compounds of type (II) are prepared and the reaction mechanism is discussed using also the results of quantum‐chemical calculations.
ChemInform Abstract: Synthesis of trans/cis‐3,4‐Disubstituted 1,2,3,4‐Tetrahydroisoquinolines by Nucleophilic Acyl Substitution of Homophthalic Anhydride with Aldimines.
Authors: Hammad Sherif F. , Smith Forrest T. 
Published: June 2013

AbstractThe mixture of the compounds (III) and (IV) is converted but only the compound (III) reacts to the tetrahydroisoquinoline (VI).
ChemInform Abstract: Ionic Liquid‐Mediated Facile Synthesis of Novel Spiroheterobicyclic Rings as Potential Antifungal and Antibacterial Drugs.
Authors: Dandia Anshu , Jain Anuj K. 
Published: June 2013

AbstractTitle compounds (IV) are synthesized via a pseudo four‐component reaction starting from pyrazolinones (I) by using an ionic liquid which acts as both solvent and catalyst.
ChemInform Abstract: Microwave‐Assisted Synthesis of Pyrimido[4,5‐b][1,6]naphthyridin‐4(3H)‐ones with Potential Antitumor Activity.
Authors: Insuasty Braulio , Becerra Diana , Quiroga Jairo , Abonia Rodrigo , Nogueras Manuel , Cobo Justo 
Published: June 2013

AbstractA catalyst‐free, microwave‐assisted synthesis of various pyrimidonaphthyridinone derivatives is developed.