bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Characterization of Terminal [Re(XCO)(CO)2(triphos)] (X=N, P): Isocyanate versus Phosphaethynolate Complexes
Authors: Alidori Simone , Heift Dominikus , Santiso‐Quinones Gustavo , Benkő Zoltán , Grützmacher Hansjörg , Caporali Maria , Gonsalvi Luca , Rossin Andrea , Peruzzini Maurizio 
Published: September 2012

AbstractThe terminal rhenium(I) phosphaethynolate complex [Re(PCO)(CO)2(triphos)] has been prepared in a salt metathesis reaction from Na(OCP) and [Re(OTf)(CO)2(triphos)]. The analogous isocyanato complex [Re(NCO)(CO)2(triphos)] has been likewise prepared for comparison. The structure of both complexes was elucidated by X‐ray diffraction studies. While the isocyanato complex is linear, the phosphaethynolate complex is strongly bent around the pnictogen center. Computations including natural bond orbital (NBO) theory, natural resonance theory (NRT), and natural population analysis (NPA) indicate that the isocyanato complex can be viewed as a classic Werner‐type complex, that is, with an electrostatic interaction between the ReI and the NCO group. The phosphaethynolate complex [Re(PCO)(CO)2(triphos)] is best described as a metallaphosphaketene with a ReI–phosphorus bond of highly covalent character.
Angiotensin Receptor Blockers Worsen Renal Function and Dyspnea on Ticagrelor: A Potential Ticagrelor‐Angiotensin Receptor Blocker Interaction?
Authors: DiNicolantonio James J. , Serebruany Victor L. 
Published: September 2012

AbstractTicagrelor is a new antiplatelet agent that was pitted against clopidogrel in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Because ticagrelor is the first oral, reversible, twice‐daily agent, sufficient information on drug interactions is not available. Our objective was to ascertain the safety of ticagrelor with other common medications. The US Food and Drug Administration Complete Response Review indicates that renal adverse events (AEs) and renal function AEs were higher in ticagrelor‐treated patients who were concomitantly treated with angiotensin receptor blockers (ARBs) >50% of study days compared to ticagrelor‐treated patients who did not receive ARBs >50% of study days. Clopidogrel‐treated patients showed a trend for an increase in adverse renal events with ARB use. However, this was not as pronounced as that observed with ticagrelor. Dyspnea was also significantly increased in patients on concomitant ticagrelor‐ARB compared to ticagrelor without concomitant ARB and clopidogrel (21.4% vs 14.6% vs 9.9%, respectively) as well as angioedema (0.15% vs 0.09%). Furthermore, in patients with a baseline estimated glomerular filtration rate (eGFR) <30 mL/min, the risk of major bleeding, death, and renal failure was increased in patients on ticagrelor compared to patients on clopidogrel. In patients on ticagrelor, ARBs significantly increased the frequency of renal related AEs, renal function AEs, and dyspnea. Moreover, in patients with a baseline eGFR <30 mL/min, the risk of major bleeding, death, and renal failure was increased in patients on ticagrelor compared to patients on clopidogrel.Dr. Serebruany is listed as an inventor for the US patent application: TREATING CARDIAC ARRHYTHMIAS, HEART FAILURE, PERIPHERAL ARTERY DISEASE AND STROKE WITH CYCLOPENTYL‐TRIAZOLO‐PYRIMIDINE OR DERIVATIVE THEREOF (USN 61/253,829) assigned to HeartDrug™ Research, and received funding for research studies with clopidogrel, and consultant fees from both clopidogrel and ticagrelor manufacturers.
Synthesis–Structure–Morphology Interplay of Bimetallic “Core–Shell” Carbon Nitride Nano‐electrocatalysts
Authors: Di Noto Vito , Negro Enrico , Polizzi Stefano , Agresti Filippo , Giffin Guinevere A. 
Published: September 2012

AbstractAn extensive morphological and structural study of two bimetallic “core–shell” carbon nitride nano‐electrocatalysts with active sites based on Pt and Ni or on Pt and Fe is reported. The core–shell electrocatalysts are obtained by the pyrolysis of a precursor obtained by decorating a support composed of conducting particles with a hybrid inorganic–organic material. The electrocatalysts were investigated by high‐resolution TEM, powder X‐ray diffraction, and μ‐Raman spectroscopy. The morphological and structural information presented here provides 1) insight into the microscopic features, affecting the electrochemical performance of the electrocatalyst materials determined in both ex situ measurements and single‐cell configurations; and 2) an opportunity to study the effect of the different precursor chemistries on the structure and morphology of the bimetallic core–shell carbon nitride nano‐electrocatalysts.
Determining how defects in connexin43 cause skeletal disease
Authors: Ton Quynh V. , Iovine M. Kathryn 
Published: September 2012

AbstractGap junction channels mediate direct cell–cell communication via the exchange of second messengers, ions, and metabolites from one cell to another. Mutations in several human connexin (cx) genes, the subunits of gap junction channels, disturb the development and function of multiple tissues/organs. In particular, appropriate function of Cx43 is required for skeletal development in all vertebrate model organisms. Importantly, it remains largely unclear how disruption of gap junctional intercellular communication causes developmental defects. Two groups have taken distinct approaches toward defining the tangible molecular changes occurring downstream of Cx43‐based gap junctional communication. Here, these strategies for determining how Cx43 modulates downstream events relevant to skeletal morphogenesis were reviewed. genesis 51:75–82, 2013. © 2012 Wiley Periodicals, Inc.
Historical demographic dynamics underlying local adaptation in the presence of gene flow
Authors: Ribeiro Ângela M. , Lopes Ricardo J. , Bowie Rauri C. K. 
Published: September 2012

AbstractThe range of a species is the result of the relative contribution of spatial tracking of environmental requirements and adaptation to ecological conditions outside the ancestral niche. The appearance of novel habitats caused by climatic oscillation can promote range expansion and accompanying demographic growth. The demographic dynamics of populations leave a signal in \ patterns. We modeled three competing scenarios pertaining to the circumstance of a range expansion by the Karoo Scrub‐Robin into newly available habitat resulting from the increasing aridification of southern Africa. Genetic variation was contrasted with the theoretical expectations of a spatial range expansion, and compared with data of a putative adaptive trait. We infer that this bird likely colonized the arid zone, as a consequence of adaptive evolution in a small peripheral population, followed by an expansion with recurrent exchange of migrants with the ancestral populations.
Lewis Acid Promoted Double Bond Isomerization of Tetrahydroxanthones
Authors: Linsenmeier Anna M. , Bräse Stefan 
Published: September 2012

AbstractHerein, a method for the isomerization of the double bonds in tetrahydroxanthones is reported. Tetrahydroxanthones are readily available from salicylaldehydes and cycloalkenones and undergo isomerization upon treatment with AlCl3. The mechanism of the isomerization and follow‐up chemistry of the products were investigated. Follow‐up chemistry such as asymmetric Corey–Bakshi–Shibata (CBS) reduction provides highly functionalized tetrahydroxanthones.
Factors predisposing to chyle leakage following thyroid cancer surgery without lateral neck dissection
Authors: Lee Yong Sang , Kim Bup‐Woo , Chang Hang‐Seok , Park Cheong Soo 
Published: September 2012

AbstractBackgroundThe aims of this study were to assess the clinicopathologic features of patients with chyle leakage following thyroid cancer surgery without lateral neck dissection and to evaluate the factors associated with chyle leakage.MethodsOf 3137 patients who underwent thyroid surgery between January 2006 and December 2007, 2314 patients (73.8%) satisfied our inclusion criteria. Patients were divided into those with (group I, n = 14) and without (group II, n = 2300) chyle leakage.ResultsThere were no significant differences between the 2 groups in clinicopathologic features including age, body mass index, extent of thyroidectomy, pathologic type, tumor size, multiplicity, capsular invasion, and coexisting thyroiditis. In univariate and multivariate analyses, male sex, age >45 years, and number of harvested central nodes were significantly associated with chyle leakage.ConclusionsIf extensive central compartment node dissection is needed, meticulous dissection is required, especially in male patients, and aged >45 years, even without lateral neck dissection. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Extended voice‐sparing surgery in selected pyriform sinus carcinoma: Techniques and outcomes
Authors: Hamoir Marc , Fievez Juliette , Schmitz Sandra , Velasco Dorris , Lengele Benoît 
Published: September 2012

BackgroundOrgan‐preservation approaches are frequently favored in the treatment of advanced pyriform sinus carcinoma. In selected cases, use of free flaps allows voice‐sparing surgery.MethodsThirteen patients underwent conservative extended laryngopharyngectomy. In 11 patients, the resection included the supraglottic larynx, whereas the whole hemilarynx was resected in 2. Reconstruction was achieved with a radial forearm free flap with the palmaris longus tendon. In hemilarynx resection, a costal graft was also used. Functional results were assessed by nasofibroscopy and swallowing videofluoroscopic tests.ResultsAt 12 months, no patient was gastrostomy dependent, whereas 1 patient remained tracheostomy dependent. At 1, 3, and 5 years, the locoregional control was 100%, 100%, and 83%; overall survival was 69.4%, 46.3%, and 30.8%; and disease‐specific survival was 81.2%, 54.5%, and 36.4%, respectively.ConclusionsIn selected patients, extended conservative laryngopharyngectomy challenges the oncologic results of organ‐preservation protocols and allows a good quality of life. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1482–1489, 2013
Factors controlling the temporal variability in dissolved oxygen regime of salmon spawning gravels
Authors: Sear D. A. , Pattison I. , Collins A. L. , Newson M. D. , Jones J. I. , Naden P. S. , Carling P. A. 
Published: September 2012

AbstractDissolved oxygen (DO) plays a critical role in the development of the juvenile stages of benthic spawning fish and salmonids in particular. Factors influencing the DO regime within spawning gravels include the accumulation of fine sediment, penetration of groundwater or surface water into the gravels, thermal regime, and the consumption of oxygen by sediment and its associated organic fractions. In this field study, we quantify the DO regime within an artificial salmon redd at high temporal resolution. The environment within the redd is shown to be complex, with large variations in DO. Application of a numerical model (SIDO‐UK) enables for the first time, the quantification of the relative contributions to DO consumption from thermal regime, sediment accumulation and sediment oxygen demand. Sediment accumulation is shown to have a minor impact on DO in the redd whereas upwelling groundwater is identified as the most likely cause of the major changes in DO. Bed mobility has a minor impact on DO regime of the redd. The effects of fine sediment and oxygen supply on salmon embryo survival are estimated. Implications for river catchment management and prospects for future research are discussed. Copyright © 2012 John Wiley & Sons, Ltd.
Phasor‐flim analysis of NADH distribution and localization in the nucleus of live progenitor myoblast cells
Authors: Wright Belinda K. , Andrews Laura M. , Jones Mark R. , Stringari Chiara , Digman Michelle A. , Gratton Enrico 
Published: September 2012

AbstractAnalysis of the cellular distributions of coenzymes including NADH may aid in understanding a cells metabolic status. We altered serum concentration (0, 2, and 10%) to induce living myoblast cells to undergo the early stages of differentiation. Through microscopy and phasor‐FLIM, we spatially mapped and identified variations in the distribution of free and bound NADH. Undifferentiated cells displayed abundant free NADH within the nucleus along with specific regions of more bound NADH. Complete serum starvation dramatically increased the fraction of bound NADH in the nucleus, indicating heightened requirement for transcriptional processes. In comparison, cells exposed to 2% serum exhibited intermediate free nuclear NADH fraction. Overall our results suggest an order of events in which a cell metabolic status alters significantly during the early stages of serum induced differentiation. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc.
Risk factors for unplanned transfer to intensive care within 24 hours of admission from the emergency department in an integrated healthcare system
Authors: Delgado M. Kit , Liu Vincent , Pines Jesse M. , Kipnis Patricia , Gardner Marla N. , Escobar Gabriel J. 
Published: September 2012

AbstractBACKGROUND:Emergency department (ED) ward admissions subsequently transferred to the intensive care unit (ICU) within 24 hours have higher mortality than direct ICU admissions.DESIGN, SETTING, PATIENTS:Describe risk factors for unplanned ICU transfer within 24 hours of ward arrival from the ED.METHODS:Evaluation of 178,315 ED non‐ICU admissions to 13 US community hospitals. We tabulated the outcome of unplanned ICU transfer by patient characteristics and hospital volume. We present factors associated with unplanned ICU transfer after adjusting for patient and hospital differences in a hierarchical logistic regression.RESULTS:There were 4,252 (2.4%) non‐ICU admissions transferred to the ICU within 24 hours. Admitting diagnoses most associated with unplanned transfer, listed by descending prevalence were: pneumonia (odds ratio [OR] 1.5; 95% confidence interval [CI] 1.2–1.9), myocardial infarction (MI) (OR 1.5; 95% CI 1.2–2.0), chronic obstructive pulmonary disease (COPD) (OR 1.4; 95% CI 1.1–1.9), sepsis (OR 2.5; 95% CI 1.9–3.3), and catastrophic conditions (OR 2.3; 95% CI 1.7–3.0). Other significant predictors included: male sex, Comorbidity Points Score >145, Laboratory Acute Physiology Score ≥7, arriving on the ward between 11 PM and 7 AM. Decreased risk was found with admission to monitored transitional care units (OR 0.83; 95% CI 0.77–0.90) and to higher volume hospitals (OR 0.94 per 1,000 additional annual ED inpatient admissions; 95% CI 0.91–0.98).CONCLUSIONS:ED patients admitted with respiratory conditions, MI, or sepsis are at modestly increased risk for unplanned ICU transfer and may benefit from better triage from the ED, earlier intervention, or closer monitoring to prevent acute decompensation. More research is needed to determine how intermediate care units, hospital volume, time of day, and sex affect unplanned ICU transfer. Journal of Hospital Medicine 2013. © 2012 Society of Hospital Medicine
MRI assessment of percutaneous ablation of liver tumors: Value of subtraction images
Authors: Tatli Servet , Acar Murat , Tuncali Kemal , Sadow Cheryl A. , Morrison Paul R. , Silverman Stuart G. 
Published: September 2012

AbstractPurpose:To evaluate the value of subtraction images when using MRI to assess liver tumors treated with percutaneous ablation.Materials and Methods:Following percutaneous ablation of 35 liver tumors, two abdominal radiologists, blinded to outcomes, independently reviewed follow‐up MRI examinations for tumoral enhancement suggestive of residual/recurrent tumor and rated their confidence level. After one year, the readers reviewed the same examinations with added subtraction images. Accuracy of the detection of residual/recurrent tumor and contrast‐to‐noise ratios (CNR; for tumoral enhancement‐to‐liver, tumoral enhancement‐to‐ablation zone, and ablation zone‐to‐liver) were calculated with and without subtraction images and compared using Wilcoxon signed rank test. Interobserver variability was computed using Kappa (κ) statistics.Results:Residual/recurrent tumor was present in 8 (23.5%) of 34 tumors. Accuracy of detecting residual/recurrent tumor with subtraction images and interobserver agreement (κ = 0.72, good) were better than accuracy of detecting residual/recurrent tumor and interobserver agreement (κ = 0.57, moderate) of enhanced MR images without subtraction. Mean CNR of subtraction images was significantly higher than that of enhanced MR images for tumoral enhancement‐to‐liver (0.2 ± 5 versus 11.6 ± 14.4, P = 0.03), tumoral enhancement‐to‐ablation zone (10.1 ± 12.5 versus 34.4 ± 29.4, P = 0.02), and ablation zone‐to‐liver (11.8 ± 13.3 versus 102.5 ± 238.4, P = 0.03).Conclusion:When using MRI, subtraction images help both detect and exclude residual/recurrent tumor following percutaneous liver ablations. J. Magn. Reson. Imaging 2013;37:407–413. © 2012 Wiley Periodicals, Inc.
Subcutaneous tumor volume measurement in the awake, manually restrained mouse using MRI
Authors: Kersemans Veerle , Cornelissen Bart , Allen Philip D. , Beech John S. , Smart Sean C. 
Published: September 2012

AbstractPurpose:To describe a combination of techniques using the excellent volumetric capacities of magnetic resonance imaging (MRI) while avoiding anesthesia and maintaining high‐throughput capability for tumor volume measurement in the awake mouse. This approach presents an alternative to calipers which, although cheap, fast, and easy to use, introduce many biases for tumor volume estimation.Materials and Methods:The murine CaNT subcutaneous xenograft model was used. A quiet and modestly T2‐weighted spin‐echo scan was acquired at 4.7T (TE = 15 msec, TR = 1100 msec, 0.5 mm isotropic resolution) while the awake mouse was held by hand in the magnet. This method was compared to standard MR in the anesthetized mouse and caliper measurements.Results:The combination of techniques used allows rapid, accurate, and reproducible measurement of subcutaneous tumor volumes in awake mice. It is less sensitive to both intra‐ and interoperator‐derived biases and avoids confounds from the compliance of the fat and skin around the tumor, as well as from the tumor itself. Moreover, the data remain available for retrieval and scrutiny and reanalysis.Conclusion:Rapid, accurate, and precise tumor volumetry can be performed in the awake mouse by handheld positioned MR. J. Magn. Reson. Imaging 2013;37:1499–1504. © 2012 Wiley Periodicals, Inc.
Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea
Authors: Cho Min‐Kyu , Jheong Weon‐Hwa , Lee Sung‐Geun , Park Chul Jong , Jung Kum Hee , Paik Soon‐Young 
Published: September 2012

AbstractA rotavirus G1P[8] strain C1‐81 was isolated from a 5‐month‐old female infant admitted to hospital with fever and severe diarrhea in Incheon, South Korea. To investigate its full genomic relatedness and its group, the full genome of strain C1‐81 was determined. Based on a full genome classification system, C1‐81 was shown to possess the typical Wa‐like genotype constellation: G1‐P[8]‐I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1. On the basis of sequence similarities, the strain was shown to be the closest related strain to contemporary human rotavirus strains with recent strains isolated in Asia. This C1‐81 strain showed the highest degree of nucleic acid similarity (98.8% and 97%) to G1 B4633‐03 and P[8] (Thai‐1604 and Dhaka8‐02), respectively. This is the first report that group A rotavirus was analyzed with G1P[8] in South Korea. The study of the complete genome of the virus will help understanding of the evolution of rotavirus. J. Med. Virol. 85:157–170, 2012. © 2012 Wiley Periodicals, Inc.
Characterization of hepatitis B virus mutations in untreated patients co‐infected with HIV and HBV based on complete genome sequencing
Authors: Tangkijvanich Pisit , Sa‐Nguanmoo Pattaratida , Avihingsanon Anchalee , Ruxrungtham Kiat , Poovorawan Kittiyod , Poovorawan Yong 
Published: September 2012

AbstractCo‐infection of HBV with HIV results in an accelerated course of HBV‐associated chronic liver disease. Several studies have shown that viral mutations are related to disease progression in mono‐infection with HBV. However, it is unclear whether HBV mutation patterns might differ between co‐infected and mono‐infected patients. To compare the frequencies and mutation patterns in the HBV genome between co‐infection and mono‐infection. Twenty‐four treatment‐naïve co‐infected and 31 treatment‐naïve mono‐infected Thai patients were included. HBV mutations were characterized by whole genome sequencing of virus serum samples. The clinical features and frequency of known clinically significant mutations were compared between the two groups. No significant difference between the groups was found with respect to sex, age and HBeAg. However, HBV DNA levels were significantly higher in co‐infected patients. The distribution of HBV genotypes was comparable between the two groups and restricted mostly to sub‐genotypes C1 and B2. An isolate with recombinants of genotypes G/C1 was also identified in a patient with co‐infection. There was no difference in the prevalence of mutations in the enhancer II/basal core promoter/precore region, pre‐S/S and polymerase genes between the two groups. In conclusion, dual infections tend to engender increased HBV DNA levels. There was no major difference in the frequencies of common HBV mutations between co‐infected and mono‐infected patients. Thus, HBV mutations may not contribute to disease pathogenesis in Thai patients with co‐infection. J. Med. Virol. 85:16–25, 2012. © 2012 Wiley Periodicals, Inc.
Segmenting Cruise Passengers Visiting Uruguay: a Factor–Cluster Analysis
Authors: Brida Juan Gabriel , Scuderi Raffaele , Seijas María Nela 
Published: September 2012

ABSTRACTThe study aims to provide a better understanding of cruise travel from passengers' characteristics and experience in two ports of call in Uruguay. A multivariate market segmentation analysis was used, on the basis of 5151 survey data collected during the 2008–2009 and 2009–2010 seasons. A correspondence analysis revealed the underlying latent factors in the set of variables. A hierarchical clustering from correspondence analysis segmented the sample into homogeneous groups. Finally, a decision tree highlighted the most predictive variables for each cluster. The study identifies distinct segments by country of residence, occupation, locations visited in Uruguay, satisfaction and previous visits to the country. Copyright © 2012 John Wiley & Sons, Ltd.
Neck dissection through a facelift incision
Authors: Melvin Thuy‐Anh N. , Eliades Steven J. , Ha Patrick K. , Fakhry Carole , Saunders John M. , Califano Joseph A. , Blanco Ray G. F. 
Published: September 2012

AbstractObjectives/Hypothesis:To determine the feasibility and safety of neck dissection through a facelift incision.Study Design:Prospective case series.Methods:Cadavers and live subjects underwent neck dissection using a facelift incision with and without endoscopic assistance. In the live facelift neck dissection (FLND), the preoperative surgical indications, staging, adjuvant therapy, intraoperative technical procedure, pathology reports on lymph nodes, and short‐term outcomes were reviewed.Results:FLND was successfully performed in four cadavers and four live subjects, including selective (less than five neck levels removed) and comprehensive (levels I–V removed) neck dissections. All levels were accessible through this approach, with additional retraction required for levels I and IV. Endoscopic assistance was required in one neck dissection for adequate visualization. Short‐term complications and number of excised lymph nodes were comparable to those from traditional neck dissection approaches.Conclusions:Open neck dissection through a facelift incision is feasible and offers an alternate approach to traditional incisions. This can be performed without requiring robotic assistance and with endoscopic assistance only in certain cases. Endoscopic assistance can offer enhanced visualization of the surgical field and complement open direct approaches in neck dissection. Although FLND offers improved cosmetic outcomes when compared to those of traditional neck incisions, further study is required to determine its efficacy and indications.