bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics
Authors: Chang Ching-Wei , Kumar Sanjay 
Published: September 2015

AbstractWhile is widely acknowledged that nonmuscle myosin II (NMMII) enables stress fibers (SFs) to generate traction forces against the extracellular matrix, little is known about how specific NMMII isoforms and functional domains contribute to SF mechanics. Here we combine biophotonic and genetic approaches to address these open questions. First, we suppress the NMMII isoforms MIIA and MIIB and apply femtosecond laser nanosurgery to ablate and investigate the viscoelastic retraction of individual SFs. SF retraction dynamics associated with MIIA and MIIB suppression qualitatively phenocopy our earlier measurements in the setting of Rho kinase (ROCK) and myosin light chain kinase (MLCK) inhibition, respectively. Furthermore, fluorescence imaging and photobleaching recovery reveal that MIIA and MIIB are enriched in and more stably localize to ROCK- and MLCK-controlled central and peripheral SFs, respectively. Additional domain-mapping studies surprisingly reveal that deletion of the head domain speeds SF retraction, which we ascribe to reduced drag from actomyosin crosslinking and frictional losses. We propose a model in which ROCK/MIIA and MLCK/MIIB functionally regulate common pools of SFs, with MIIA crosslinking and motor functions jointly contributing to SF retraction dynamics and cellular traction forces.
Higher blood hematocrit predicts hyperuricemia: a prospective study of 62897 person-years of follow-up
Authors: Zeng Chao , Wei Jie , Yang Tuo , Li Hui , Xiao Wen-feng , Luo Wei , Gao Shu-guang , Li Yu-sheng , Xiong Yi-lin , Lei Guang-hua 
Published: September 2015

AbstractThis prospective study aimed to investigate the relationship between higher hematocrit (Hct) level and hyperuricemia (HU) incidence. A total of 27540 subjects were included. Baseline Hct was classified into four categories based on the quartile distribution of the study population. A cox proportional hazards regression was used to evaluate the risk of HU incidence across the Hct quartiles after adjusting a number of potential confounding factors. Out of the 62897 person-years of follow-up, 2745 new cases of HU were developed. In models adjusted for known risk factors of HU, higher Hct was used to predict HU incidence independently in a graded manner (p = 0.02): compared with subjects in the lowest quartile, subjects in the highest quartile of Hct (hazard ratio = 1.20; 95% confidence interval: 1.03–1.41) were n20% more likely to develop HU. Sensitivity analysis indicated that the hazard ratios increased with the extension of the minimum follow-up interval. When the minimum follow-up interval was restricted to 4 years, subjects in the highest quartile of Hct were 70% more likely to develop HU, compared with the lowest quartile. Higher Hct, a routinely measured inexpensive biomarker was independently associated with the incidence of HU even within the normal range.
Mechanisms for Enhanced Hydrophobicity by Atomic-Scale Roughness
Authors: Katasho Yumi , Liang Yunfeng , Murata Sumihiko , Fukunaka Yasuhiro , Matsuoka Toshifumi , Takahashi Satoru 
Published: September 2015

AbstractIt is well known that the close-packed CF3-terminated solid surface is among the most hydrophobic surfaces in nature. Molecular dynamic simulations show that this hydrophobicity can be further enhanced by the atomic-scale roughness. Consequently, the hydrophobic gap width is enlarged to about 0.6 nm for roughened CF3-terminated solid surfaces. In contrast, the hydrophobic gap width does not increase too much for a rough CH3-terminated solid surface. We show that the CF3-terminated surface exists in a microscopic Cassie–Baxter state, whereas the CH3-terminated surface exists as a microscopic Wenzel state. This finding elucidates the underlying mechanism for the different widths of the observed hydrophobic gap. The cage structure of the water molecules (with integrated hydrogen bonds) around CH3 terminal assemblies on the solid surface provides an explanation for the mechanism by which the CH3-terminated surface is less hydrophobic than the CF3-terminated surface.
Columnar grown copper films on polyimides strained beyond 100%
Authors: Sun Jeong-Yun , Lee Hae-Ryung , Hwan Oh Kyu 
Published: September 2015

AbstractMany flexible electronic devices contain metal films on polymer substrates to satisfy requirements for both electrical conductivity and mechanical durability. Despite numerous trials to date, the stretchability of metal interconnects remains an issue. In this paper, we have demonstrated a stretchable metal interconnect through control of the texture of a copper film with columnar grown grains on a polyimide (PI) substrate. The columnar grown copper films (CGC films) were deposited by regulating radio frequency (RF) sputtering powers. CGC films were able to sustain their electrical conductivity at strains above 100%. Instead of ultimate electrical discontinuity by channel crack propagation, CGC films maintained their conductivity by forming ligament structures, or a ‘conductive net,’ through trapped micro-cracks. XRD, AFM and in situ SEM analysis were used to investigate these stretchable conductors.
ABIF Manager: simple reading and editing of ABIF formatted files
Authors: Beran Pavel , Mraz Ivan 
Published: September 2015

AbstractSummary: ABIF Manager is simple application for low-level access to ABIF formatted files. Those are produced by Data Collection software based on the data, collected from capillary sequencing machine. The application shows all the data as readable text, which can be easily edited.Availability and implementation: The program source code and compiled executable is freely available at: https://sourceforge.net/projects/abifmanager/Contact: pavel.beran@centrum.cz
Facilitators and Barriers to Participation in a Peer Support Intervention for Veterans With Chronic Pain
Authors: Matthias Marianne S. , Kukla Marina , McGuire Alan B. , Damush Teresa M. , Gill Nabiha , Bair Matthew J. 
Published: September 2015

Objective:
To understand facilitators and barriers to participation in a peer support intervention for self-management of chronic pain.

Methods:
After completing a pilot intervention study, peer coaches and their veteran patients took part in a qualitative, semistructured interview to explore their experiences with the intervention. Data were analyzed using an immersion/crystallization approach.

Results:
Three facilitators and 2 barriers to patient participation in a peer support intervention for veterans with chronic pain emerged. Facilitators were (1) having a shared identity as veterans, (2) being partnered with a person who also has chronic pain, and (3) support from the study staff. Barriers were (1) logistical challenges, and (2) challenges to motivation and engagement in the intervention.

Discussion:
Awareness of facilitators and barriers to participation in a peer-supported self-management program for chronic pain, as well as strategies to capitalize on facilitators and mitigate barriers, are essential for further study and ultimate clinical implementation of such a program.
Magnetic Resonance Enterography Healing and Magnetic Resonance Enterography Remission Predicts Improved Outcome in Pediatric Crohn Disease
Authors: Sauer Cary G. , Middleton Jeremy P. , McCracken Courtney , Loewen Jonathan , Braithwaite Kiery , Alazraki Adina , Martin Diego R. , Kugathasan Subra 
Published: September 2015

ABSTRACTBackground:Mucosal healing predicts clinical remission and improved outcomes in patients with Crohn disease (CD). Magnetic resonance enterography (MRE) is a noninvasive imaging modality that can assess small and large bowel wall inflammation. Evidence suggests that MRE may be an acceptable alternative to evaluate mucosal healing over endoscopy. Our objective is to determine whether MRE remission predicts clinical remission at follow‐up in children with CD.Methods:We performed an institutional review board–approved retrospecitve chart review using our prospectively maintained MRE CD database. Inclusion criteria were all children who underwent an MRE more than 6 months after diagnosis with CD who had follow‐up of at least 1 year from imaging.Results:A total of 101 children with CD underwent MRE, a median of 1.3 years from diagnosis with a median follow‐up of 2.8 years after MRE. Active inflammation was detected in 65 MRE studies, whereas 36 MRE studies demonstrated MRE remission. A total of 88.9% of children demonstrating MRE remission were in clinical remission at follow‐up, whereas only 44.6% of those demonstrating MRE active inflammation achieved clinical remission. Children demonstrating MRE‐active inflammation were more likely to have a change in medication (44.6% vs 8.3%) and more likely to undergo surgery (18.5% vs 2.8%).Conclusions:MRE remission is associated with clinical remission at follow‐up at least 1 year after MRE. MRE remission was associated with fewer medication changes and fewer surgeries suggesting that, similar to endoscopic remission, MRE remission demonstrates improved outcome. Additional research is needed to confirm that MRE can be used as a surrogate for mucosal healing.
Peritoneal dialysis exit-site leak complicated by peritoneal dialysis-related peritonitis due to Actinomyces neuii
Authors: El Kossi Mohsen M. , Darwish Sanaa Fadel , Agwuh Kenneth , Milupi Manyando 
Published: September 2015

Introduction:

Actinomyces neuii is a rare cause of peritoneal dialysis-related peritonitis.

Case presentation:
A 66-year-old male had end-stage renal disease on peritoneal dialysis treatment for 30 months. He developed exit-site leak with infection. Diphtheroids were isolated and considered initially as skin commensals. Dialysis treatment was suspended and on reinstitution he developed peritoneal dialysis-related peritonitis. The organism isolated from the peritoneal dialysis fluid was A. neuii.

Conclusion:
This case was treated successfully with peritoneal dialysis catheter removal and oral amoxicillin.
A case of cutaneous penicilliosis in a child with acute myeloid leukaemia
Authors: Krishnan Sandhya G. , Sim Tee Nancy Wen , Tan Ai Ling , Tan Ah Moy , Aan Koh Mark Jean , Chong Chia Yin , Thoon Koh Cheng , Hui Tan Natalie Woon 
Published: September 2015

Introduction:
We present a case of cutaneous penicilliosis in a paediatric patient with acute myeloid leukaemia (AML).

Case report:
A 2-year-old boy with AML first developed probable pulmonary aspergillosis during induction chemotherapy in an overseas centre in May 2013, and was treated with AmBisome and voriconazole. When he was admitted to our centre with relapsed AML in October 2013, he was given a fifth course of chemotherapy, and treated with AmBisome for probable pulmonary aspergillosis in view of pulmonary nodular opacities on computed tomography. He thereafter developed an erythematous skin lesion with central eschar on his right hand and left calf. Serum and bronchoalveolar lavage galactomannan antigen (GM Ag) indices increased to a value of >10. AmBisome was changed to voriconazole, and caspofungin was added for 10 days. The left calf skin biopsy showed abundant fungal hyphae with septations. A skin culture grew Penicillium citrinum with MICs (μg ml− 1) of: caspofungin 0.016, itraconazole 0.5, amphotericin 1.5 and voriconazole >256.Caspofungin and itraconazole were commenced, and voriconazole was discontinued. The skin lesions and serial GM Ag indices improved. The patient later developed increasing GM Ag indices to a value of >10, which was attributed to Aspergillus flavus left pulmonary mycetoma, which was surgically resected. He eventually succumbed to relapsed AML after a bone-marrow transplant.

Conclusion:
To the best of our knowledge, this is the first paediatric case of P. citrinum infection. Rising GM Ag indices were attributed to cross-reactivity of Penicillium spp. with GM Ag enzyme immunoassays.
The politics of corporate social responsibility or: why Milton Friedman has been right all along
Authors: Orlitzky Marc 
Published: September 2015

Purpose– The purpose of this paper is to revisit the debate and reorient research on corporate social responsibility (CSR), empirically documents the political-ideological biases inherent in CSR. It concludes with possible remedies to this problem.Design/methodology/approach– The approach taken in this literature review is informed by the author’s viewpoint on the growing industry of social activists, who are pushing business toward the adoption of an ever-growing panoply of quasi-regulations commonly identified as CSR. The approach is complemented by a critique of stakeholder theory.Findings– The literature review provides empirical support for Milton Friedman’s (1970) claim that the values underpinning CSR are driven by a socialist-collectivist agenda, which is inherently opposed to capitalist/libertarian values of free enterprise and individualism.Practical implications– Without critical reflection on the leftwing ideology instantiated by CSR, the business community may unwittingly adopt and sustain values that undermine free markets.Originality/value– Without critical reflection on the leftwing ideology instantiated by CSR, business and research communities may unwittingly promote values that, stealth-like, undermine individual liberty and the capitalist foundations of free markets.
The human factors/ergonomics studies for respirators: a review and future work
Authors: Chen Yumiao , Wang Jianping , Yang Zhongliang 
Published: September 2015

Purpose
– The purpose of this paper is to provide an overview of the human factors/ergonomics (HFE) studies for respirator.

Design/methodology/approach
– This review paper describes and discusses the various factors and methodologies of HFE, for the purpose of better considering human factors, used in respirator studies and further human-centered product development.

Findings
– Many attempts have been made to study human factors for respirators mainly including fit, human performance, comfort, and mood. Physical, psychological, and physiological indices of people are extremely valuable to HFE studies for respirator. Objective and subjective measures were methodologies widely used. Quantitative and qualitative approaches were adopted to illustrate the human performance and well-being influenced by respirators. A summary table presented with major methods used for indices of respirators in the field of HFE. According to the current researches, this review indicated three particular challenges facing HFE studies of respirators now.

Practical implications
– With the ever increasing role of protection from air pollution in society, respirator has become an increasingly important part of our daily lives. HFE intervene in optimizing the relationships between respirators and the human using them. Plenty of efforts have been dedicated for the development of protection capability, but HFE studies for respirators are lacking. In recent years, there has been a tremendous interest in introducing HFE research methods that can evaluate respirators from the perspective of human and translate them into constraints for designing human-centered respirators.

Originality/value
– This is a first paper in the field of HFE studies for respirator, which will remain helpful to the scientific community to start further human-centered research work and product development.
Content strategies and audience response on Facebook brand pages
Authors: Tafesse Wondwesen 
Published: September 2015

Purpose
– The purpose of this paper is to analyse Facebook brand posts along dimensions of vividness, interactivity, novelty, brand consistency and content type and tests how these characteristics influence audience response in terms of liking and sharing brand posts.

Design/methodology/approach
– The sample comprised 191 brand posts sourced from the Facebook brand pages of five top selling automotive brands in the UK. Audience response was operationalised using brand post likes and brand post shares, while brand post characteristics were operationalised according to relevant theory. Poisson regression models were tested to measure the effect of brand post characteristics on audience response.

Findings
– The findings indicate that brand post vividness has a significant positive effect on brand post shares, but not on brand post likes. Brand post interactivity has a significant negative effect on both brand post likes and brand post shares. Brand post novelty and brand post consistency have a significant positive effect on both brand post likes and brand post shares. Finally, brand post content type has a significant positive effect on brand post likes, but not brand post shares.

Practical implications
– The findings underscore the need for marketers to develop a systematic content strategy for Facebook brand pages. With this in mind, the study proposes several evidence based suggestions.

Originality/value
– This study contributes to the literature first by synthesising and testing brand post characteristics that were overlooked in prior research and second by developing theoretically consistent operationalisation for already familiar brand post characteristics. These enhancements resulted in a final model with a superior explanatory power.
Quality characteristics and acceptability of cookies from sweet potato – maize flour blends
Authors: Adeyeye Samuel Ayofemi , Akingbala John O. 
Published: September 2015

Purpose– This study aims to assess the quality characteristics and acceptability of cookies from sweet potato–maize flour blends and to determine nutritional quality, color and palatability traits and to compare the effects with that of wheat cookies, so as to suggest a cost-effective production method to bakers and retailers. This would ensure food security, enhanced health, combat malnutrition problems and improve the production of the crops.Design/methodology/approach– Cookies were prepared by the method reported by Okaka and Isieh (1990), Abayomiet al.(2013), Onabanjo and Ighere (2014) with modification. Flour (200 g) from each sample of different flour blends was used for the experiment. Sugar (80 g) was creamed with margarine (100 g) until light and fluffy constituency was obtained using Kenwood chef with initial minimum speed, and the speed increased stepwise until the mark of 6 on the chef indicator was attained. Whole egg (60 g) was added, then followed by flour (200 g), powdered milk (20 g), baking powder (0.1 g) and salt (1 g) were added and mixed until a stiff paste (batter) was obtained. The batter was rolled on a floured board using a rolling pin to a thickness of 0.2-0.3 cm. The rolled batter was cut into circular shapes with a cutter and arranged on a greased tray and baked at 1500°C for 20 minutes. The cookies were brought out, cooked and packaged in cellophane bag until used for laboratory analysis.Findings– The results revealed that substitution of sweet potato flour with maize flour significantly (p< 0.05) reduced the protein from 6.8-4.4 per cent, moisture from 5.3-5.0 per cent, crude fibre from 3.4-2.5 per cent and fat from 9.8-8.5 per cent of the composite flours and the cookies. The ash and sugar contents were increased from 4.3-5.8 per cent for ash and 2.1-3.9 per cent for sugar with increase in sweet potato flour substitution. The calorific value of the cookies decreased from 457-397 cal/100 g as the percentage of sweet potato flour increased in the maize flour cookies. Sensory evaluation results showed that the colour, texture, taste and overall acceptability changed significantly (p< 0.05) with increase in sweet potato flour substitution. The optimum substitution level was 40 per cent; above this, the product becomes less acceptable to the consumer.Research limitations/implications– Fabrication and production processing machines that use sweet potato will be a great challenge.Originality/value– This research is of value to the bakery industry or retailers. The optimum substitution level of sweet potato flour was 40 per cent, and it appears to be a promising measure from the view of practicability. The relative ease of getting sweet potato flour makes it superior to other imported flour like wheat and in reducing cost of importation of wheat to Nigeria.
Quality characteristics and storage stability of emu meat nuggets formulated with finger millet (Eleusine coracana) flour
Authors: Chatli Manish Kumar , Kumar Pavan , Mehta Nitin , Verma Akhilesh K , Kumar Devendra , Malav Om Prakash 
Published: September 2015

Purpose
– The purpose of this study was to develop functional emu meat nuggets incorporated with finger millet flour (FMF) with high fibre content and improved oxidative stability.

Design/methodology/approach
– FMF was incorporated at 4, 6 and 8 per cent levels with replacement of emu meat in nuggets formulation and on the basis of various physico-chemical, instrumental colour and sensory parameters, 6 per cent FMF was selected as optimum. The functional emu meat nuggets incorporated with optimum level of FMF as well as control were aerobically packaged in low density polyethylene (LDPE) bags and stored for 21 days at refrigeration (4 ± 1°C) and evaluated for oxidative stability, microbiological quality and sensory attributes at regular interval of 7 days.

Findings
– The fat content showed significant (p
<
0.05) decrease, whereas the crude fibre content increased significantly (p
<
0.05) with the increasing levels of incorporation. The sensory scores for all the attributes in 6 per cent FMF-incorporated product were higher than control. During entire storage studies, the thiobarbituric acid reactive substances (TBARS), free fatty acid and peroxide value followed an increasing trend for control as well as treatment product; however, treatment showed a significantly (p
<
0.05) lower value than control throughout the storage period. Standard plate count increased significantly (p
<
0.05) for control and treatment product, but the counts were lower than the prescribed limits even on 21st day of storage.

Practical implications
– The developed products will have functional value by increasing the calcium and dietary fibre content by utilizing the minor cereals. This will be highly beneficial to both the agriculture and meat industry.

Originality/value
– The research findings demonstrated the use of FMF in the development of calcium- and fibre-enriched emu meat nuggets with improved oxidative stability.
Evaluation of quality characteristics of restructured spent hen meat blocks incorporated with oat meal
Authors: Gupta Swati , Sharma B. D. , Mendiratta S. K. 
Published: September 2015

Purpose
– This study aims to evaluate the effect of oat meal on the quality characteristics of restructured spent hen meat blocks. Spent hen meat is considered as poor because of comparatively higher toughness and less juiciness.

Design/methodology/approach
– Oat meal (1:1 hydration, w/w) was incorporated at the levels of 4, 6 and 8 per cent by replacing the lean meat in prestandardized restructured spent hen meat blocks formulation and assessed for physico-chemical and sensory quality.

Findings
– The product yield and pH of restructured spent hen meat blocks (RSHMB) were significantly higher at 8 per cent oat meal as compared to control. Shear force values of RSHMB with various levels of oat meal incorporation were significantly lower than control. There were no significant differences in the general appearance, texture, binding, juiciness and overall acceptability scores of RSHMB with different levels of oat meal and control. However, there was a marginal increase in binding and juiciness of RSHMB with increase in the level of oat meal. The optimum incorporation level of oat meal in RSHMB was adjudged as 8 per cent, which also resulted in reduction of production cost by Rs. 14.4/kg as compared to control.

Research limitations/implications
– The trials can be further carried to evaluate the storage stability of developed RSHMB.

Originality/value
– The paper has demonstrated potential of oat meal as an extender in the development of RSHMB, which also reduced the cost of production.