bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Short-Term Outcome to Exercise and Manual Therapy for People With Hip Osteoarthritis
Authors: French Helen P. , Galvin Rose , Cusack Tara , McCarthy Geraldine M. 
Published: August 2013

Background
Physical therapy for hip osteoarthritis (OA) has shown short-term effects but limited long-term benefit. There has been limited research, with inconsistent results, in identifying prognostic factors associated with a positive response to physical therapy.

Objectives
The purpose of this study was to identify potential predictors of response to physical therapy (exercise therapy [ET] with or without adjunctive manual therapy [MT]) for hip OA based on baseline patient-specific and clinical characteristics.

Design
A prognostic study was conducted.

Methods
Secondary analysis of data from a multicenter randomized controlled trial (RCT) (N=131) that evaluated the effectiveness of ET and ET+MT for hip OA was undertaken. Treatment response was defined using OMERACT/OARSI responder criteria. Ten baseline measures were used as predictor variables. Regression analyses were undertaken to identify predictors of outcome. Discriminative ability (sensitivity, specificity, and likelihood ratios) of significant variables was calculated.

Results
The RCT results showed no significant difference in most outcomes between ET and ET+MT at 9 and 18 weeks posttreatment. Forty-six patients were classified as responders at 9 weeks, and 36 patients were classified as responders at 18 weeks. Four baseline variables were predictive of a positive outcome at 9 weeks: male sex, pain with activity (&lt;6/10), Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale score (&lt;34/68), and psychological health (Hospital Anxiety and Depression Scale score &lt;9/42). No predictor variables were identified at the 18-week follow-up. Prognostic accuracy was fair for all 4 variables (sensitivity=0.5–0.58, specificity=0.57–0.72, likelihood ratios=1.25–1.77), indicating fair discriminative ability at predicting treatment response.

Limitations
The short-term follow-up limits the interpretation of results, and the low number of identified responders may have resulted in possible overfitting of the predictor model.

Conclusions
The authors were unable to identify baseline variables in patients with hip OA that indicate those most likely to respond to treatment due to low discriminative ability. Further validation studies are needed to definitively define the best predictors of response to physical therapy in people with hip OA.
Radiosurgery for parasagittal and parafalcine meningiomas
Authors: Ding Dale , Xu Zhiyuan , McNeill Ian T. , Yen Chun-Po , Sheehan Jason P. 
Published: August 2013

Object
Parasagittal and parafalcine (PSPF) meningiomas represent the second most common location for intracranial meningiomas. Involvement of the superior sagittal sinus or deep draining veins may prevent gross-total resection of these tumors without significant morbidity. The authors review their results for treatment of PSPF meningiomas with radiosurgery.

Methods
The authors retrospectively reviewed the institutional review board–approved University of Virginia Gamma Knife database and identified 65 patients with 90 WHO Grade I parasagittal (59%) and parafalcine (41%) meningiomas who had a mean MRI follow-up of 56.6 months. The patients' mean age was 57 years, the median preradiosurgery Karnofsky Performance Status score was 80, and the median initial tumor and treatment volumes were 3 and 3.7 cm3, respectively. The median prescription dose was 15 Gy, isodose line was 40%, and the number of isocenters was 5. Kaplan-Meier analysis was used to determine progression-free survival (PFS). Univariate and multivariate Cox regression analyses were used to identify factors associated with PFS.

Results
The median overall PFS was 75.6 months. The actuarial tumor control rate was 85% at 3 years and 70% at 5 years. Parasagittal location, no prior resection, and younger age were found to be independent predictors of tumor PFS. For the 49 patients with clinical follow-up (mean 70.8 months), the median postradiosurgery Karnofsky Performance Status score was 90. Symptomatic postradiosurgery peritumoral edema was observed in 4 patients (8.2%); this group comprised 3 patients (6.1%) with temporary and 1 patient (2%) with permanent clinical sequelae. Two patients (4.1%) died of tumor progression.

Conclusions
Radiosurgery offers a minimally invasive treatment option for PSPF meningiomas, with a good tumor control rate and an acceptable complication rate comparable to most surgical series.
Cerebrovascular complications and granuloma formation after wrapping or coating of intracranial aneurysms with cotton gauze and human fibrin adhesives: results from a single-center patient series over a 5-year period
Authors: Beitzke Markus , Leber Klaus A. , Deutschmann Hannes , Gattringer Thomas , Poltrum Birgit , Fazekas Franz 
Published: August 2013

Object
Reinforcement of intracranial aneurysms (IAs) by wrapping or coating is a well-established therapeutic approach to those IAs not amenable to any other definitive treatment, but has been associated with complications such as parent artery narrowing, granuloma formation, and ischemic stroke. The goal of this study was to systematically investigate cerebrovascular complications following this procedure.

Methods
The authors' hospital database was searched for all patients who underwent wrapping or coating of IAs with cotton gauze and human fibrin adhesives between October 2006 and October 2011. The follow-up records of these patients were extracted, including regular clinical visits and vascular imaging.

Results
Five hundred sixty-seven patients were treated for IAs over the 5-year period: 303 patients underwent endovascular strategies and 264 underwent craniotomies. Wrapping or coating of IAs was performed in 20 patients (3.5%). Parent artery narrowing occurred in 5 (25%) of the 20 patients and was associated with major ischemic strokes in 4 patients and severe headache in another. Ischemic strokes were associated with parent artery narrowing, which occurred early postoperatively in 2 patients or was a consequence of granuloma formation in 2 patients 1 and 2 months after the procedure, respectively.

Conclusions
These data should add to the awareness of significant cerebrovascular complications following wrapping or coating of IAs with cotton gauze and human fibrin adhesives and indicate that major ischemic strokes need to be included in the risk/benefit considerations during decision making for such treatment strategies. Patients who receive IA wrapping should be monitored and followed up closely for arterial narrowing and granuloma formation.
Results of Gamma Knife surgery for Cushing's disease
Authors: Sheehan Jason P. , Xu Zhiyuan , Salvetti David J. , Schmitt Paul J. , Vance Mary Lee 
Published: August 2013

Object
Cushing's disease is a challenging neuroendocrine disorder. Although resection remains the primary treatment option for most patients, the disease persists if there is residual or recurrent tumor. Stereotactic radiosurgery has been used to treat patients with persistent Cushing's disease after a prior resection. The authors report on the long-term risks and benefits of radiosurgery for Cushing's disease.

Methods
A retrospective review of a prospectively collected database of radiosurgery patients was undertaken at the University of Virginia. All patients with Cushing's disease treated with Gamma Knife surgery (GKS) were identified. Those without at least 12 months of clinical and radiological follow-up were excluded from this analysis. Rates of endocrine remission, tumor control, and adverse events were assessed. Statistical methods were used to identify favorable and unfavorable prognostic factors.

Results
Ninety-six patients with the required follow-up data were identified. The mean tumor margin dose was 22 Gy. The median follow-up was 48 months (range 12–209.8 months). At the last follow-up, remission of Cushing's disease occurred in 70% of patients. The median time to remission among all patients was 16.6 months (range 1–165.7 months). The median time to remission in those who had temporarily stopped taking ketoconazole at the time of GKS was 12.6 months, whereas it was 21.8 months in those who continued to receive ketoconazole (p < 0.012). Tumor control was achieved in 98% of patients. New loss of pituitary function occurred in 36% of patients. New or worsening cranial neuropathies developed in 5 patients after GKS, with the most common involving cranial nerves II and III.

Conclusions
Gamma Knife surgery offers a high rate of tumor control and a reasonable rate of endocrine remission in patients with Cushing's disease. The cessation of cortisol-lowering medications around the time of GKS appears to result in a more rapid rate of remission. Delayed hypopituitarism and endocrine recurrence develop in a minority of patients and underscore the need for long-term multidisciplinary follow-up.
Methylation markers of malignant potential in meningiomas
Authors: Vengoechea Jaime , Sloan Andrew E. , Chen Yanwen , Guan Xiaowei , Ostrom Quinn T. , Kerstetter Amber , Capella Devan , Cohen Mark L. , Wolinsky Yingli , Devine Karen , Selman Warren , Barnett Gene H. , Warnick Ronald E. , McPherson Christopher , Chiocca E. Antonio , Elder J. Bradley , Barnholtz-Sloan Jill S. 
Published: August 2013

Object
Although most meningiomas are benign, about 20% are atypical (Grade II or III) and have increased mortality and morbidity. Identifying tumors with greater malignant potential can have significant clinical value. This validated genome-wide methylation study comparing Grade I with Grade II and III meningiomas aims to discover genes that are aberrantly methylated in atypical meningiomas.

Methods
Patients with newly diagnosed meningioma were identified as part of the Ohio Brain Tumor Study. The Infinium HumanMethylation27 BeadChip (Illumina, Inc.) was used to interrogate 27,578 CpG sites in 14,000 genes per sample for a discovery set of 33 samples (3 atypical). To verify the results, the Infinium HumanMethylation450 BeadChip (Illumina, Inc.) was used to interrogate 450,000 cytosines at CpG loci throughout the genome for a verification set containing 7 replicates (3 atypical), as well as 12 independent samples (6 atypical). A nonparametric Wilcoxon exact test was used to test for difference in methylation between benign and atypical meningiomas in both sets. Heat maps were generated for each set. Methylation results were validated for the 2 probes with the largest difference in methylation intensity by performing Western blot analysis on a set of 20 (10 atypical) samples, including 11 replicates.

Results
The discovery array identified 95 probes with differential methylation between benign and atypical meningiomas, creating 2 distinguishable groups corresponding to tumor grade when visually examined on a heat map. The validation array evaluated 87 different probes and showed that 9 probes were differentially methylated. On heat map examination the results of this array also suggested the existence of 2 major groups that corresponded to histological grade. IGF2BP1 and PDCD1, 2 proteins that can increase the malignant potential of tumors, were the 2 probes with the largest difference in intensity, and for both of these the atypical meningiomas had a decreased median production of protein, though this was not statistically significant (p = 0.970 for IGF2BP1 and p = 1 for PDCD1).

Conclusions
A genome-wide methylation analysis of benign and atypical meningiomas identified 9 genes that were reliably differentially methylated, with the strongest difference in IGF2BP1 and PDCD1. The mechanism why increased methylation of these sites is associated with an aggressive phenotype is not evident. Future research may investigate this mechanism, as well as the utility of IGF2BP1 as a marker for pathogenicity in otherwise benign-appearing meningiomas.
Reduction in neural injury with earlier delivery in a mouse model of congenital myelomeningocele
Authors: Al-Shanafey Saud N. , Fontecha Cesar G. , Canyadell Marius Aguirre , Soldado Francisco C. , Rojo Alejandro A. , Conesa Xavier J. , Toran Nuria T. , Ibanez Vicenç M. , Peiro Jose L. 
Published: August 2013

Object
The authors undertook this study to assess the effect of preterm delivery with respect to neural protection in a congenital myelomeningocele (MMC) mouse model.

Methods
After confirmation of pregnancy in 15 female mice, a congenital MMC model was produced by administration of retinoic acid on the 7th day of gestation. The pregnant mice underwent cesarean sections on Days 15 (n = 5, Group E15), 17 (n = 5, Group E17), and 19 (n = 5, Group E19). Histological analyses were conducted on the lumbar defect and on the craniocervical junction in all fetuses with MMC.

Results
Fetuses in Group E19 showed the most significant injury to neural tissue of the spinal cord at the MMC area followed by those in Group E17, with Group E15 being the least affected. All groups exhibited a degree of Chiari malformation; Group E19 was the most affected, followed by Group E17, and Group E15 was the least affected.

Conclusions
Development of both Chiari malformation and exposed spinal cord injury are progressive during gestation. Preterm delivery in this mouse model of congenital MMC may minimize the degree of injury to the spinal cord neural tissue and the degree of Chiari malformation.
Le cas Annette Zelman et les débuts de la « Solution finale » en France (mai-juin 1942)
Authors: Joly Laurent 
Published: August 2013

Le 22 mai 1942, Annette Zelman, vingt ans, juive, est — arrêtée à Paris à la suite d’une dénonciation du père de son fiancé. Un mois plus tard, elle est déportée à destination d’Auschwitz, où elle disparaît. Ce drame individuel vient rappeler que, pour les nazis, tous les juifs étaient destinés à mourir et que, même en France où la majorité a survécu, la fatalité pouvait s’abattre sur n’importe qui, y compris une étudiante française vivant dans un milieu privilégié. Un cas d’arbitraire pur, dans le contexte des débuts de la « Solution finale » en Europe de l’Ouest, que la mise au jour d’archives familiales inédites permet d’éclairer dans toute sa dimension humaine.
Syndicalistes croyants et panafricains
Authors: Blum Françoise 
Published: August 2013

Cet article s’intéresse aux réseaux syndicalistes — « croyants » en Afrique francophone dans les années 1960. La balkanisation syndicale, moins connue que la balkanisation politique en Afrique s’est accompagnée du maintien de liens panafricains, formalisés ou non dans des Internationales, telle l’Union panafricaine des travailleurs croyants. Il subsiste après les indépendances des liens encore forts avec les syndicats de l’ancienne métropole, ainsi qu’avec les Internationales syndicales. Les impératifs de la construction nationale ainsi que les aléas politiques conditionnent une pratique syndicale, dont les acteurs peuvent être alternativement au faîte du pouvoir, en prison ou en exil.
Approche du merveilleux paysager : le dialogue entre l’art du jardin et la littérature
Authors: Reyniès Justine de 
Published: August 2013

Dans le dernier tiers du xviiie siècle, les écrits qui ont accompagné l’essor du jardin paysager ont été le lieu d’un renouvellement de l’imaginaire du lieu magique. Rattachés au genre « surprenant » dans le cadre d’une application des catégories rhétoriques au paysage, les traits constitutifs de la topique du lieu enchanté sont repris et intégrés au sein d’une sémiotique de l’espace qui attribue à certains éléments le pouvoir de signifier un au-delà du visible. Parallèlement, avec la Dissertation on Oriental Gardening (1772) de William Chambers, une jonction s’opère entre l’écriture du paysage et le genre moderne du conte de fées, notamment dans sa variante orientale illustrée par Les Mille et une nuits. Le lieu créé ou « hanté » par des êtres surnaturels s’identifie désormais au territoire du rêve, lui-même assimilé à l’espace mental où se déploie le génie artistique. Parmi les paysages oniriques des récits de l’âge romantique, les décors de Laura de George Sand et Le Domaine d’Arnheim illustrent l’héritage laissé à la création littéraire par la féerie pittoresque des Lumières.
When reality has become a pale reflection of our images... Imagining faith in Christ in a postmodern context
Authors: Veldsman D. P. 
Published: August 2013

Closely following the philosopher Richard Kearney’s "The wake of imagination" (1988) and "The poetics of imagining" (1991), the historical trial of the act of imagination is explicated. The implications of this very act of imagination are explored within a postmodern context. The question of the reconstruction of a christology within such apostmodern context, characterised by epistemological undecideahility and depthlessness, is addressed.
Combined AB Externo and AB Interno Revision of Failed Filtering Blebs with Adjunctive Mitomycin C
Authors: Magacho Leopoldo , Shetty Rajesh K. 
Published: August 2013

Purpose: To report the results of combined ab externo and ab interno revision with mitomycin C (MMC) of failed filtering blebs in glaucoma patients. Methods: Glaucoma patients with a failed trabeculectomy who had undergone internal and external revision with MMC in the last 6 years with at least 12 months of follow-up were considered. All study patients followed the same protocol in the operating room: injection of 0.2 mL of MMC (0.4 mg/mL) 2 cm lateral from the bleb followed by internal revision with an iris spatula and external revision with a 26-G × ½” needle. Success was defined as an intraocular pressure (IOP) ≥6 mm Hg and ≤18 mm Hg with (qualified) or without (absolute) any ocular hypotensive drugs. Results: The study included 25 eyes of 22 glaucoma patients. Mean age was 65.2 ± 10.5 years. Mean follow-up was 26.9 ± 10.3 months. The IOP was reduced from 24.5 ± 6.0 mm Hg preoperatively to 10.0 ± 3.3 mm Hg at the last visit (p<0.001). The number of ocular hypotensive medications was reduced from 1.8 ± 1.0 to 0.2 ± 0.6 (p<0.001). There was no change in visual acuity (0.83 ± 0.75 vs 0.83 ± 0.74, p = 0.7). Three patients developed choroidal detachment, another eye had a transient hypotony with maculopathy, and 2 patients developed cataract. Absolute success was achieved in 80% of eyes, and qualified success in 16% of eyes. Conclusions: Combined ab externo and ab interno revision with MMC can be an effective technique to revitalize failed filtering blebs in glaucoma patients with minimal complications.
Intraocular Pressure Elevation after Vitrectomy for various Vitreoretinal Disorders
Authors: Hasegawa Yumi , Okamoto Fumiki , Sugiura Yoshimi , Okamoto Yoshifumi , Hiraoka Takahiro , Oshika Tetsuro 
Published: August 2013

Purpose: To determine the incidence of and risk factors for intraocular pressure (IOP) elevation in the immediate postoperative period after vitrectomy for various vitreoretinal disorders. Methods: A prospective study was performed in 228 consecutive patients with various vitreoretinal disorders. The IOP was measured before surgery, at the end of surgery, and at 5 hours and 1 day after surgery using Tono-Pen XL®. The IOP at the end of surgery was adjusted to 15.0 ± 2.0 mm Hg. Results: Intraocular pressure elevation (>25 mm Hg) was found in 55 (24.1%) and 52 (22.8%) patients at 5 hours and 1 day postoperatively, respectively. The IOP at 5 hours was significantly lower in patients with macular hole (MH) than in those with diabetic macular edema, proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy, or rhegmatogenous retinal detachment (RD). The IOP at 1 day was significantly higher in patients with PDR and RD than in those with MH and epiretinal membrane. Multiple regression analysis revealed that IOP at 5 hours postoperatively had a significant correlation with the number of laser photocoagulation, preoperative IOP, combined cataract surgery, and 20-gauge vitrectomy. The IOP at 1 day postoperatively was significantly associated with these 4 parameters as well as the severity of postoperative vitreous hemorrhage and use of expanding gas tamponade. Conclusions: Intraocular pressure elevation was found in approximately one-quarter of cases within 1 day following vitrectomy. The risk factors for IOP elevation included number of laser photocoagulation, combined cataract surgery, severity of postoperative vitreous hemorrhage, and use of expanding gas tamponade.
Reproducibility of Choroidal Thickness Measurements in Healthy Turkish Subjects
Authors: Karaca Emine Esra , Özdek Şengül , Yalçin Nuriye Gökçen , Ekici Feyzahan 
Published: August 2013

Purpose: To assess intraobserver and interobserver reproducibility of the measurement of choroidal thickness by using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: A prospective, cross-sectional study was performed at Gazi University Ophthalmology Department. The macular areas of the right eyes of 110 healthy volunteers with no ophthalmic or systemic disease were recruited. Choroidal thickness was measured at the fovea and at 1000-μm intervals from the foveal center in both temporal and nasal directions. Each examiner measured choroidal thickness 30 days after the first measurement to assess intraobserver variability. Interobserver and intraobserver reproducibility were described by intraclass correlation coefficient (ICC) and coefficient of variation (CV). Results: The mean age was 44.0 ± 14.7 years (range 18-70 years). The mean choroidal thickness at the fovea was 315.5 ± 78.6. All the parameters evaluated were highly reproducible. Intraobserver CV of choroidal thickness measurements ranged from 24.76% to 35.74%, and the CV of subfoveal choroidal thickness was 24.92. The intraobserver and interobserver intraclass correlation coefficient was greater than 0.90 for all the parameters. Repeatability was slightly better at locations not exceeding 400 μm. Conclusions: Choroidal thickness measurements obtained by EDI-OCT showed good repeatability for healthy Turkish subjects; EDI-OCT examinations of choroid are reliable in healthy eyes.
Creation of Autogenous Radial Cephalic Direct Wrist Access for Hemodialysis in the Elderly Using Microsurgery
Authors: Pirozzi Nicola , Giuliani Anna , Grandi Tommaso , Coclite Daniela , Luciani Remo , Punzo Giorgio , Menè Paolo 
Published: August 2013

Purpose Guidelines recommend autogenous radial-cephalic AV fistula (RCAVF) as the first choice for hemodialysis. Concern has been raised that this is not suitable in the elderly. We assessed the results of microsurgery for RCAVF creation comparatively in patients older and younger than 70 years. Methods We prospectively followed 126 patients for three years. After systematic clinical and ultrasound assessment, a RCAVF was created using a surgical microscope. Patency was assessed immediately, at one week, one month and one year. Outcomes were recorded and stratified into two groups: <70y and >70y. Results RCAVF was created in 75.4% and 70.8% of the <70y and >70y groups, respectively. Incidence of early failure was 11% (<70y) and 13% (>70y). Primary and secondary patency at one year was 67% and 84% (<70y) versus 63% and 80% (>70y). Conclusions Microsurgery enabled the creation of RCAVF in >70y with acceptable risk of failure and slight differences by comparison with <70y. Older age should not preclude RCAVF creation.