bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critiquing Indian Middle‐Class Principles of Mobility: Examining Transgender Representation in Post‐Millennial OTT Media in India
Authors: Subramanian Prerna 
Published: August 2024

ABSTRACTThis literature review critically examines the need to incorporate critiques of urban, middle‐class, Hindu, upper‐caste mediated regulation of transgender mobility within media analyses of transgender representation in contemporary films and other streaming (OTT) media in India. The essay explores how the real and imagined/narrative mobility of marginalized groups, such as Dalit women, Muslim women, sex workers, and transgender communities, has been historically disciplined by the cultural and political practices of the upper‐caste Hindu middle class family. Material‐discursive practices of this class upper‐caste, middle‐class Hindu family shape and get shaped by gendered and caste‐coded interests of neoliberal productivity and heteropatriarchal respectability, determining the ideal geographies of the city and the relational cartographies of the nation. Films and media also get influenced by and shape these discursive practices by prioritizing a middle‐class sense of place in their worldmaking efforts. The narrative schema of such cultural production designs the movement of characters in such a way that they move in directions considered recognizable, legible and acceptable for the Indian middle class family. The primary aim of this review is to delineate the literature on spatial imaginaries of the middle class family and how the cultural practices of this class imagine and render legible the marginalized, allowing for a critical analysis of the co‐production of middle‐class spatial control and transgender visibility in cultural texts like that of contemporary streaming media. Furthermore, this study explores the emplacement of the marginalized as evident in critiques of representations of Dalit, Muslim, and sex worker communities in Indian cinema, emphasizing the necessity of applying similar analyses to trans representation. This spatially sensitive critique is crucial for understanding transgender struggles in India, highlighting the importance of examining middle‐class spatial imaginaries that shape trans representation and the politics of regulated transgender (im)mobilities.
Improvement of self‐administration experience with a new injection device: Real‐life experience with risankizumab in patients with psoriasis
Authors: Brunasso Alexandra Maria Giovanna , Salvi Ilaria , Sorbara Stefania , Muracchioli Andrea , De Col Elena , Baldari Manuela , Parodi Aurora , Cozzani Emanuele , Burlando Martina 
Published: August 2024

AbstractBackgroundTrypanophobia or “needle phobia” represents a potential hindrance to the effective management of chronic diseases whenever an injectable therapy might be required, especially in case of frequent administrations. Psoriasis, a chronic dermatologic disease, can be effectively treated with biologic drugs administered subcutaneously. Thankfully, anti‐IL‐23 drugs require few administrations per year and are available in prefilled pens that hide the needle, thus representing a convenient option in patients with trypanophobia.MethodsAn observational multicentric study was conducted on patients with moderate‐to‐severe psoriasis who were treated with 75 mg × 2 risankizumab prefilled syringe therapy for more than 6 months and reported a loss of efficacy measured by the Psoriasis Area and Severity Index (PASI) from PASI 90 to PASI 75 attributed to a reduction of adherence due to trypanophobia. The patients were switched to 1 prefilled pen of risankizumab 150 mg and asked to fill out the Self‐Injection Assessment Questionnaire (SIAQ) before and after the injection at week 0 and at the following administration after 12 weeks. Subjects scored each item of the SIAQ on a 5‐point scale, scores were later transformed from 0 (worst experience) to 10 (best experience).ResultsTwenty‐two patients were enrolled. The mean SIAQ predose domain scores were 5.5 for feelings about injection, 6.2 for self‐confidence, and 6.4 for satisfaction with self‐injection. After dose scores were higher (> 8.5) for each of the six domains at Week 0 and even higher after 12 weeks (> 9.0).ConclusionsUser‐friendly devices, such as prefilled pens, and a lower number of injections improved patient satisfaction in a group of patients with psoriasis on treatment with biologic drugs. We believe that treatment adherence could be positively influenced by such changes in the way of administration of a biologic treatment.
Perspectives on donor‐derived infections from the Notify Library
Authors: Len Oscar , Greenwald Melissa A , Navarro Aurora , Petrisli Evangelia , Carella Claudia , Grossi Paolo Antonio , Feltrin Giuseppe , Cardillo Massimo 
Published: August 2024

AbstractIt is impossible to eliminate the potential for transmission of donor‐derived infections (DDI) when using medical products of human origin (MPHO). However, a thoughtful and systematic approach to donor evaluation can mitigate the risk. Prevention is a key issue, and physicians must maintain a high index of suspicion and remain vigilant in evaluating MPHO donors or recipients, as well as stay current on emerging infections. Biovigilance is the systematic monitoring of serious adverse reactions and events (SARE) that ensures the quality and safety of MPHO in transplantation. The Notify Library with its 2808 references is an available didactic tool that could support physicians in donor or recipient evaluation, inform biovigilance activity, and benefit the international scientific community. It provides free access to a large collection of many different types of SARE, identified mainly through the review of published articles and case reports from national or regional surveillance programs. The Notify Library includes many well‐documented records of SARE in the field of DDI, representing a useful tool for assessing SARE associated with transplantation. It is continuously updated with new records, especially when a new type of incident is first reported. All types of described incidents may have educational value while guiding detection, investigation, or risk management. Sharing the lessons learned from these incidents represents an important educational opportunity that can help improve organ donation processes and achieve higher standards of quality and safety.
Navigating the Asia‐Pacific region plasma therapies landscape: Insights from the 2023 Asia‐Pacific Plasma Leaders' Network meetings
Authors: Bhatnagar Sonu , Burnouf Thierry , Prevot Johan , Faber Jean‐Claude , Büechel René , Maryuningsih Yuyun Siti , Khanh Bach Quoc , Mai Nguyen Thi , Nakanishi Hideo , Kataoka Masako 
Published: August 2024

AbstractThe Asia‐Pacific Plasma Leaders' Network (APPLN) plays a crucial role in addressing the regional shortage of plasma‐derived medicinal products (PDMPs), particularly in low‐ and middle‐income countries (LMICs). It provides a platform for experts to share their expertise and drive multi‐stakeholder collaborations. While several PDMPs are acknowledged by the World Health Organization (WHO) as life‐saving therapeutics on the Model List of Essential Medicine for treating various chronic and acute life‐threatening diseases, there are still many inadequacies in the availability and affordability of PDMPs. These challenges arise from insufficient domestic supplies of plasma suitable for fractionation, as well as a lack of technical and financial capabilities to implement contract or domestic plasma fractionation programmes. At two separate dialogue forums organized by the APPLN in 2023, experts discussed the unmet needs of PDMPs for individuals living with haemophilia and immunodeficiencies in the region. They also highlighted the limited access to early diagnosis and patient‐centred care in several LMICs. To address these issues, there is an urgent need to increase the availability of high‐quality domestic plasma for fractionation. Adopting a stepwise approach to utilize unused recovered plasma and establishing contract fractionation programmes could be viable strategies to potentially enhance PDMP availability in LMICs. However, achieving this goal requires improving existing domestic infrastructures for blood collection, implementing adequate policy reforms and fostering competent local leadership. Ultimately, there is no ‘one‐size‐fits‐all’ strategy for securing safe plasma proteins for all patients in need. Collaborative efforts are essential for achieving progressive self‐sufficiency in PDMPs.
Radiographic and computed tomographic findings of intrathoracic ectopic liver in a dog
Authors: Jeong Jeongyun , Chang Jupill , Lee Seunghee , Kim Kyuchang , Kim Jaehwan , Eom Kidong 
Published: August 2024

AbstractA 5‐year‐old spayed female Maltese was referred due to a suspected diaphragmatic hernia. Radiography revealed a soft tissue mass in the right caudal thorax with loss of diaphragm cupola dome‐shape. A diaphragmatic hernia was considered, but surgical exploration revealed an intact diaphragm and unremarkable liver lobes. CT after a surgical inspection showed all intact liver lobes and intrathoracic mass connected to the liver. The intrathoracic mass was retracted to the abdomen by incising the diaphragm. Histopathologic examination revealed hepatocellular vacuolar degeneration, indicating an intrathoracic ectopic liver. Intrathoracic ectopic liver should be included in the differential diagnosis when diaphragmatic hernia is suspected in radiography.
Comparison of Laminar and Turbulent K–Omega Shear Stress Transport Models Under Realistic Boundary Conditions Using Clinical Data for Arterial Stenosis
Authors: Al-Rawi Mohammad , Belkacemi Djelloul , Al-Jumaily Ahmed M. 
Published: August 2024

Abstract
Early diagnosis of cardiovascular diseases (CVDs), including arterial stenosis, enables targeted treatments that reduce CVD mortality. It is vital to improve the accuracy of early diagnostic tools. Current computational studies of stenosis use mathematical models, such as laminar and k–omega shear stress transport (SST) models, available in ansys (Fluent and CFX), openfoam, and comsol software packages. Users can adjust boundary conditions, such as inlet velocity and outlet pressure using user-defined functions (UDFs) with different expressions and constant values. However, currently there is no rule over what to impose at these boundaries, and previous studies have used various assumptions, such as rigid artery wall, one-way fluid–structure interaction (FSI) or two-way FSI, and the blood's Newtonian or non-Newtonian material properties. This variety in construction has associated deviations of the models from the clinical data and lessens the value of the models as potential diagnostic or predictive tools for medical practitioners. In this study, we examine arterial stenosis models, with severities of 20%, 40%, and 50%, compared with the healthy artery analyzed in terms of strain energy to the artery wall. Additionally, we investigate elastic walls using one-way FSI, comparing with laminar and k–omega SST. These boundary conditions are based on clinical data. The results regarding the strain energy (mJ) behavior along the artery wall show that the k–omega SST model outperforms the laminar model for short arterial segments and under the Newtonian assumption with a no-slip boundary wall and turbulent flow.
A Multivariable Numerical Investigation of Wavy-Based Microchannel Heat Sink Geometry Toward Optimal Thermal Performance
Authors: Eltaweel Ahmed , Hassan Ibrahim 
Published: August 2024

Abstract
This research provides a comprehensive multivariable comparative investigation of the effect of various microchannel configurations on their thermal performance. Three-dimensional fluid flow and heat transfer simulations are performed with different arrangements of the channel's width tapering and cross-sectional aspect ratio with an emphasis on the synergistic proven effects of geometrical parameters in innovatory combinations. Results confirm that wavy channels are significantly superior to straight channels in terms of thermal performance due to the creation of secondary flow (Dean Vortices), which improves the processes of advective mixing and, therefore, overall heat transfer characteristics with minimal pumping power penalty. Width tapering of wavy channels also shows better thermal resistance than untapered wavy channels producing almost 10% thermal resistance improvement. The study indicates a significant dependency of thermal performance on the cross-sectional aspect ratio of the channel, which suggests that there are ideal tapering and aspect ratio conditions. An innovative wavy-tapered microchannel heat sink has been introduced, featuring an optimal parametric configuration and directionally alternating coolant flow. This design results in additional thermal resistance improvement by 15% and significantly improves substrate temperature distribution uniformity. Overall, the results demonstrate the superior potential of the configuration for high-end electronics cooling tasks. These results provide interpretive insight into microchannel heat sink design and optimization.
Study on the Influence of Volute Throat Jet on Excitation Vibration Alleviation of Radial Turbine Blade
Authors: Yu Xiaoshun , Li Yanzhao , Liu Zhen , Yin Bo , Wang Leilei 
Published: August 2024

Abstract
Turbine blade fracture, resulting from high-cycle fatigue (HCF), is the most commonly observed failure mode of turbochargers. In a vaneless turbine, the radial turbine blade is susceptible to HCF under excessive aerodynamic excitation due to the flow field distortion caused by the volute tongue. The present study explores a technique to mitigate blade excitation by reducing pressure disturbance in the volute tongue area. The gas with higher pressure in the inlet section of the volute is transferred to the low-static pressure area upstream of the volute tongue through a throat jet hole. The usage of high-pressure gas improved the homogeneity of the flow field near the volute tongue. The study investigates the mitigation of high-pressure gas jet on turbine blade excitation, the impact of jet hole geometry on the suppression effect of the blade vibration, and the effect of high-pressure jet on turbine performance using numerical simulation of unsteady flow fields. The results indicate that the jet flow has a substantial impact on dampening the blade vibrations. The harmonic pressure amplitude at the monitor point located within the high blade vibration amplitude region is reduced by up to 56%. Generalized pressure analysis reveals that the aerodynamic excitation of the turbine blades is significantly reduced. Experimental evidence verifies the effectiveness of the jet hole scheme in reducing blade vibration. Moreover, the jet hole has a negligible effect on turbine efficiency. However, there is a degree of increased stress in the volute tongue with a jet hole which needs to be evaluated in engineering applications.
Guideline for Large-Scale Analysis of Centrifugal Blower Using Wall-Resolved Large Eddy Simulation
Authors: Tsukamoto Kazuhiro , Kato Chisachi 
Published: August 2024

Abstract
To reduce the number of prototypes during product design and accurately predict unsteady phenomena occurring at off-design points, a method for accurately predicting the performance of centrifugal blowers through numerical analysis is required. This article presents a guideline for accurately predicting the performance of centrifugal blowers using compressible flow analysis with large eddy simulation (LES). In LES analysis, it is important to have a grid resolution that resolves the minimum vortex scale near the wall (referred to as wall-resolved LES) and to consider detailed geometry such as the length of the suction pipe. The calculations in this study used a model blower, which is a scale model of a single-stage centrifugal blower for use in industrial plants. The model blower was experimentally measured for various parameters such as the blower pressure coefficient, the static-pressure-rise coefficients of the impeller and vane-less diffuser, the shaft power, and the pressure fluctuations at the inlet of the impeller and the inlet of the vane-less diffuser. The results of these measurements were compared with those obtained from the wall-resolved LES. The study confirmed that the accuracy of performance prediction can be improved to less than a 4.0% error in the blower pressure coefficient at both design and off-design operating points by resolving the minimum vortex scale with 14.6 billion-grid elements and considering the detailed geometry.
Regulatory Challenges in AI/ML-Enabled Medical Devices: A Scoping Review and Conceptual Framework
Authors: Kaladharan Sanju , Manayath Dhanya , Gopalakrishnan Rejikumar 
Published: August 2024

Abstract
Amidst rapid advancements in artificial intelligence and machine learning-enabled medical devices (AI/ML-MD), this article investigates the regulatory challenges highlighted in the current academic literature. Using a PRISMA-guided scoping review, 18 studies were selected for in-depth analysis to highlight the multifaceted issues in regulating AI/ML-MD. The study's findings are organized into key themes: adaptive AI/ML, usability and stakeholder engagement, data diversity and use, health disparities, synthetic data use, regulatory considerations, medicolegal issues, and cybersecurity threats. The scoping review reveals numerous challenges associated with the regulation of AI/ML-based medical devices, reflecting various sustainability pillars. The study advocates for integrating sustainability principles into the materiovigilance ecosystem of AI/ML-MD and proposes a novel sustainable ecosystem for AI/ML-MD materiovigilance. This proposed ecosystem incorporates social, economic, and environmental sustainability principles to create a comprehensive and balanced regulatory approach. By presenting a thorough analysis of regulatory challenges, the study provides policymakers with a nuanced understanding of the complex landscape surrounding these technologies. This insight enables the development of informed strategies and solutions to address regulatory gaps and ensure the safe and effective integration of AI/ML-MD into healthcare systems.
Effect of Adding N2/H2O to Ethylene Laminar Diffusion Flame on Soot Formation
Authors: Luo Guang , Zhang Yindi , Liu Bing , Liu Jiani , Xu Bidong , Adjei Takyi Shadrack 
Published: August 2024

Abstract
The method of adding exhaust gas to fuel to reduce soot and nitrogen oxide (NOX) is called exhaust gas recirculation (EGR). This article was carried out to investigate the effect of adding N2 and H2O to the fuel side to dilute ethylene on soot generation in laminar diffusion flame by combining experiment and numerical simulation. In the experiment, the flame was optically detected, and the volume fraction of soot and temperature was reconstructed. The numerical simulation adopts a simplified GRI-Mech 3.0 ethylene 23-step combustion reaction mechanism. It introduces virtual species FX (F1H2O, F2H2O, F3H2O) to isolate the effects of H2O addition on thermal, transport, chemical, and density effects. The results show that the numerical values agree well with the experimental results. At the same dilution ratio, the direct involvement of H2O in the reaction affects the flame temperature and intermediate products, leading to a more significant suppressing effect on soot than N2 dilution. After decoupling the effects of H2O, it was found that there are two main reasons for the decrease of soot caused by the addition of H2O. The first is the dilution effect and thermal effect, which hinder the hydrogen extraction C2H2 addition (HACA) reaction by reducing the concentration of intermediate component C2H2, greatly inhibiting the surface growth rate of soot, and playing a decisive role in reducing the formation of soot. The second is the chemical effect, which mainly enhances the oxidation process of soot by increasing the concentration of OH free radicals during combustion through the elementary reaction OH + H2 ↔ H + H2O. Additionally, the degree of influence of various effects on soot was qualitatively determined as follows: dilution effect &gt; chemical effect &gt; thermal effect &gt; density effect &gt; transport effect.
Interplay Between Nucleation and Kinetics in Dynamic Twinning
Authors: Chua Janel , Agrawal Vaibhav , Walkington Noel , Gazonas George , Dayal Kaushik 
Published: August 2024

Abstract
In this work, we apply a phase-field modeling framework to elucidate the interplay between nucleation and kinetics in the dynamic evolution of twinning interfaces. The key feature of this phase-field approach is the ability to transparently and explicitly specify nucleation and kinetic behavior in the model, in contrast to other regularized interface models. We use this to study two distinct problems where it is essential to explicitly specify the kinetic and nucleation behavior governing twin evolution. First, we study twinning interfaces in 2D. When these interfaces are driven to move, we find that significant levels of twin nucleation occur ahead of the moving interface. Essentially, the finite interface velocity and the relaxation time of the stresses ahead of the interface allow for nucleation to occur before the interface is able to propagate to that point. Second, we study the growth of needle twins in antiplane elasticity. We show that both nucleation and anisotropic kinetics are essential to obtain predictions of needle twins. While standard regularized interface approaches do not permit the transparent specification of anisotropic kinetics, this is readily possible with the phase-field approach that we have used here.
Numerical Analysis for Cutting a Subsea Bundle
Authors: Chanaa Ahmad , Ivanovic Ana , Hastings Astley 
Published: August 2024

Abstract
The decommissioning of subsea bundles presents a significant challenge to the industry. Bundles are unique to the North Sea with more than 70 bundles currently in use with diameters reaching 1400 mm. The 1992 Convention for the Protection of the Marine Environment of the North East Atlantic, which is the international treaty governing offshore decommissioning in the North East Atlantic, presumes that all installations will be removed and the London Convention prohibits dumping at sea so the decommissioning of subsea bundles is a legal requirement. This study identifies that cutting and lifting subsea bundles is the best option for decommissioning bundles and is the first use of finite element analysis to design such a tool to cut bundles and determine the forces required. This modeling of the hydraulic shear indicates that the required shearing force is 18.65 MN when using a blade with a 60-deg cutting angle and a 180-deg shape angle. The modeling further demonstrates that the shearing force varies with the cutting and shape angles. On the other hand, the modeling for the guillotine cutter indicates a required shearing force of 19 MN. This analysis demonstrates the parameters required to design a subsea bundle-cutting tool and is the first step toward developing a practical tool for decommissioning subsea bundles.