bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of Family, School, and Peer Influence on Volunteerism Scale Among Adolescents
Authors: Law Ben M. F. , Shek Daniel T. L. , Ma Cecilia M. S. 
Published: February 2013

Social systems, particularly family, school, and peer, are especially critical in influencing adolescents to participate in volunteer service; however, no objective measures of this construct exist. Objectives: This study examined the psychometric properties of the Family, School, and Peer Influence on Volunteerism scale (FSPV) among Chinese adolescents. The FSPV is an instrument that assesses the perceived influence of these social systems on adolescent volunteerism. There are nine identical items for each of the three systems. Method: The FSPV was administered to 2,819 early adolescents in Hong Kong. Results: Confirmatory factor analyses revealed four factors, namely, “Family,” “School,” “Peer,” and “Extrinsic influence.” The FSPV also demonstrated good internal consistency, construct validity, and criterion-related validity. Conclusion: The psychometric properties of FSPV are adequate in the assessment of the perceived influence of social systems on volunteer service participation in Chinese adolescents.
The effects of actuator selection on non-volitional postural responses to torso-based vibrotactile stimulation
Authors: Lee Beom-Chan , Martin Bernard J , Sienko Kathleen H 
Published: February 2013

AbstractBackgroundTorso-based vibrotactile feedback may significantly reduce postural sway in balance-compromised adults during quiet standing or in response to perturbations. However, natural non-volitional postural responses to vibrotactile stimulation applied to the torso remain unknown.MethodsThe primary goal of this study was to determine, for two types of actuators (tactors) and in the absence of instruction, whether vibrotactile stimulation induces a directional postural shift as a function of stimulation location. Eleven healthy young adults (20 – 29 years old) were asked to maintain an upright erect posture with feet hip-width apart and eyes closed. Two types of tactors, Tactaid and C2, which differ in design and stimulation strength, were placed on the skin over the right and left external oblique, internal oblique, and erector spinae muscles in a horizontal plane corresponding approximately to the L4/L5 level. Each tactor of the same type was activated twice randomly for each individual location and twice simultaneously for all locations at a frequency of 250 Hz for a period of 5 s.ResultsVibration applied over the internal oblique and erector spinae muscle locations induced a postural shift in the direction of the stimulation regardless of the tactor type. For the aforementioned four locations, the root-mean-square (RMS) and power spectral density (PSD) of the body sway in both the A/P and M/L directions were also significantly greater during the vibration than before or after, and were greater for the C2 tactors than for the Tactaid tactors. However, simultaneous activation of all tactors or those over the external oblique muscle locations did not produce significant postural responses regardless of the tactor type.ConclusionThe results suggest that the use of a torso-based vibrotactile sensory augmentation display should carefully consider the tactor type as well as the instruction of corrective movements. Attractive instructional cues (“move in the direction of the vibration”) are compatible with the observed non-volitional response to stimulation and may facilitate postural adjustments during vibrotactile biofeedback balance applications.
Short-term role of the dietary total antioxidant capacity in two hypocaloric regimes on obese with metabolic syndrome symptoms: the RESMENA randomized controlled trial
Authors: Lopez-Legarrea Patricia , de la Iglesia Rocio , Abete Itziar , Bondia-Pons Isabel , Navas-Carretero Santiago , Forga Lluis , Martinez J Alfredo , Zulet M Angeles 
Published: February 2013

Abstract

Background
Dietary strategies seem to be the most prescribed therapy in order to counteract obesity regarding not only calorie restriction, but also bioactive ingredients and the composition of the consumed foods. Dietary total antioxidant capacity (TAC) is gaining importance in order to assess the quality of the diet.

Methods
Ninety-six obese adults presenting metabolic syndrome (MetS) symptoms completed an 8-week intervention trial to evaluate the effects of a novel dietary program with changes in the nutrient distribution and meal frequency and to compare it with a dietary pattern based on the American Heart Association (AHA) guidelines.
Anthropometric and biochemical parameters were assessed at baseline and at the endpoint of the study, in addition to 48-hours food dietary records.

Results
Both diets equally (p > 0.05) improved MetS manifestations. Dietary TAC was the component which showed the major influence on body weight (p = 0.034), body mass index (p = 0.026), waist circumference (p = 0.083) and fat mass (p = 0.015) reductions. Transaminases (ALT and AST) levels (p = 0.062 and p = 0.004, respectively) were associated with lower TAC values.

Conclusion
RESMENA diet was as effective as AHA pattern for reducing MetS features. Dietary TAC was the most contributing factor involved in body weight and obesity related markers reduction.

Trial registration

http://www.clinicaltrials.gov; NCT01087086
Regulation of protein translation initiation in response to ionizing radiation
Authors: Trivigno Donatella , Bornes Laura , Huber Stephan M , Rudner Justine 
Published: February 2013

Abstract

Background
Proliferating tumor cells require continuous protein synthesis. De novo synthesis of most proteins is regulated through cap-dependent translation. Cellular stress such as ionizing radiation (IR) blocks cap-dependent translation resulting in shut-down of global protein translation which saves resources and energy needed for the stress response. At the same time, levels of proteins required for stress response are maintained or even increased. The study aimed to analyze the regulation of signaling pathways controlling protein translation in response to IR and the impact on Mcl-1, an anti-apoptotic and radioprotective protein, which levels rapidly decline upon IR.

Methods
Protein levels and processing were analyzed by Western blot. The assembly of the translational pre-initiation complex was examined by Immunoprecipitation and pull-down experiments with 7-methyl GTP agarose. To analyze IR-induced cell death, dissipation of the mitochondrial membrane potential and DNA fragmentation were determined by flow cytometry. Protein levels of the different initiation factors were down-regulated using RNA interference approach.

Results
IR induced caspase-dependent cleavage of the translational initiation factors eIF4G1, eIF3A, and eIF4B resulting in disassembly of the cap-dependent initiation complex. In addition, DAP5-dependent initiation complex that regulates IRES-dependent translation was disassembled in response to IR. Moreover, IR resulted in dephosphorylation of 4EBP1, an inhibitor of cap-dependent translation upstream of caspase activation. However, knock-down of eIF4G1, eIF4B, DAP5, or 4EBP1 did not affect IR-induced decline of the anti-apoptotic protein Mcl-1.

Conclusion
Our data shows that cap-dependent translation is regulated at several levels in response to IR. However, the experiments indicate that IR-induced Mcl-1 decline is not a consequence of translational inhibition in Jurkat cells.
Extracorporeal membrane oxygenation (ECMO) in patients with H1N1 influenza infection: a systematic review and meta-analysis including 8 studies and 266 patients receiving ECMO
Authors: Zangrillo Alberto , Biondi-Zoccai Giuseppe , Landoni Giovanni , Frati Giacomo , Patroniti Nicolò , Pesenti Antonio , Pappalardo Federico 
Published: February 2013

Abstract
Introduction
H1N1 influenza can cause severe acute lung injury (ALI). Extracorporeal membrane oxygenation (ECMO) can support gas exchange in patients failing conventional mechanical ventilation, but its role is still controversial. We conducted a systematic review and meta-analysis on ECMO for H1N1-associated ALI.

Methods
CENTRAL, Google Scholar, MEDLINE/PubMed and Scopus (updated 2 January 2012) were systematically searched. Studies reporting on 10 or more patients with H1N1 infection treated with ECMO were included. Baseline, procedural, outcome and validity data were systematically appraised and pooled, when appropriate, with random-effect methods.

Results
From 1,196 initial citations, 8 studies were selected, including 1,357 patients with confirmed/suspected H1N1 infection requiring intensive care unit admission, 266 (20%) of whom were treated with ECMO. Patients had a median Sequential Organ Failure Assessment (SOFA) score of 9, and had received mechanical ventilation before ECMO implementation for a median of two days. ECMO was implanted before inter-hospital patient transfer in 72% of cases and in most patients (94%) the veno-venous configuration was used. ECMO was maintained for a median of 10 days. Outcomes were highly variable among the included studies, with in-hospital or short-term mortality ranging between 8% and 65%, mainly depending on baseline patient features. Random-effect pooled estimates suggested an overall in-hospital mortality of 28% (95% confidence interval 18% to 37%; I2 = 64%).

Conclusions
ECMO is feasible and effective in patients with ALI due to H1N1 infection. Despite this, prolonged support (more than one week) is required in most cases, and subjects with severe comorbidities or multiorgan failure remain at high risk of in-hospital death.
Learning and memory in Rhodnius prolixus: habituation and aversive operant conditioning of the proboscis extension response
Authors: Vinauger Clément , Lallement Hélène , Lazzari Claudio R. 
Published: February 2013

SUMMARY
It has been largely accepted that the cognitive abilities of disease vector insects may have drastic consequences on parasite transmission. However, despite the research effort that has been invested in the study of learning and memory in haematophagous insects, hitherto few conclusive results have been obtained. Adapting procedures largely validated in Drosophila, honeybees and butterflies, we demonstrate here that the proboscis extension response (PER) of the haematophagous insect Rhodnius prolixus can be modulated by non-associative (habituation) and associative (aversive conditioning) learning forms. Thermal stimuli were used as both unconditional stimulus (appetitive temperatures) and negative reinforcement (thermal shock). In the first part of this work, the PER was habituated and dishabituated to thermal stimuli, demonstrating the true central processing of information and discarding motor fatigue or sensory adaptation. Habituation was revealed to be modulated by the spatial context. In the second part, bugs that were submitted to aversive operant conditioning stopped responding with PER to thermal stimulation more quickly than by habituation. They were able to use their training experience when tested up to 72 h later. Our work constitutes the first demonstration of PER habituation and conditioning in a blood-sucking insect and provides reproducible experimental tools for the study of the mechanisms underlying learning and memory in disease vectors.
Vancomycin Clearance in High-Volume Venovenous Hemofiltration
Authors: Paciullo Christopher A , Harned Kevin C , Davis George A , Connor Michael J , Winstead P Shane 
Published: February 2013

OBJECTIVE To report the pharmacokinetic and pharmacodynamic properties of vancomycin in 4 patients undergoing high-volume continuous venovenous hemofiltration (CVVH). CASE SUMMARY Data from 4 patients prescribed high-volume CVVH for acute renal failure treated with vancomycin were analyzed. Vancomycin plasma concentrations were measured 4 and 24 hours after the end of a 1-hour vancomycin infusion. The mean therapy fluid rate on initiation of vancomycin was 56.2 mL/kg/h (range 48.0–65.5). The mean loading dose of vancomycin was 18.3 mg/kg (range 14.7–19.7). Median vancomycin concentration 4 hours after the dose was 18.1 mg/L (range 13.1–30.0). At 24 hours after the dose, only 1 patient had a detectable vancomycin concentration (5.2 mg/L). DISCUSSION There was a large variability in the clearance of vancomycin in this patient population. Current strategies for dosing vancomycin may lead to subtherapeutic trough concentrations. Vancomycin dosing in this patient population should be based on a detailed assessment of the CVVH prescription, vancomycin concentrations, and clinical needs and response. CONCLUSIONS An initial vancomycin dose of 20–25 mg/kg with frequent monitoring and adjustment is recommended for patients receiving high-volume CVVH.
Syntheses and applications of small metallic nanorods from solution and physical vapor deposition
Authors: Stagon Stephen P. , Huang Hanchen 
Published: February 2013

AbstractMetallic nanorods have a wide range of important technological applications. Fabrication of metallic nanorods of ~100 nm using physical vapor deposition (PVD) has been commonplace for several decades. On this length scale, nanorods have similar functionalities to bulk thin films with the advantage of increased surface area. When the lateral dimension is decreased to ~10 nm new functionalities emerge that are not present in thin film counterparts, such as catalysis. Small metallic nanorods, those ~10 nm, have classically been made through solution-based synthesis. Alternatively, recent advances in scientific understanding, a framework of nanorod growth, have opened the door to the fabrication of small nanorods through PVD. Growing small nanorods through PVD offers technologically relevant advantages over solution-based processing like direct control of aspect ratio, pure high-vacuum processing, and oriented attachment to a substrate. Among materials, gold (Au) has a wide range of technological applications and is a good prototype for understanding the behavior of common face center cubic metals. This article reviews solution processing and PVD of small metallic nanorods using Au as a prototype, in terms of scientific understanding and fabrication knowledge, and further compares and contrasts the two approaches.
Locoregional Interaction of Ixabepilone (Ixempra) After Breast Cancer Radiation
Authors: Takiar Vinita , Strom Eric A. , Baumann Donald P. , Meric-Bernstam Funda , Alvarez Ricardo H. , Gonzalez-Angulo Ana M. 
Published: February 2013

Abstract

Learning Objectives
Describe the significant locoregional clinical interaction that may result from ixabepilone chemotherapy following radiation. Explain the importance of awareness, detection, and management of radiation recall by both the medical and the radiation oncologist. Describe the spectrum of toxicity represented by radiation recall that can range from erythema to chest wall necrosis requiring reconstructive surgery.

Background.
Radiation recall is an acute inflammatory reaction within a previously irradiated field triggered by chemotherapy administration. We observed a series of patients with unexpectedly severe reactions that included radiation recall and delayed healing when patients received the microtubule stabilizer ixabepilone (Ixempra; Bristol-Myers Squibb, Princeton, NJ) after radiation. We therefore decided to evaluate our experience in patients receiving ixabepilone following radiotherapy.

Methods.
We performed a retrospective chart review of all patients treated with curative intent in the Department of Radiation Oncology at the MD Anderson Cancer Center from 2008–2011 who received any ixabepilone after completion of external-beam radiation therapy. These patients received adjuvant ixabepilone on one of two protocols, either for locally advanced breast cancer or for metastatic breast cancer. In total, 19 patients were identified and their charts were subsequently reviewed for evidence of ixabepilone-related toxicity.

Results.
Of the 19 patients identified who received ixabepilone following radiation therapy, three (15.8%) had unexpectedly serious reactions in the months following radiation therapy. Complications included delayed wound closure and drain placement into the seroma, intense erythema, and delayed wound closure and grade 4 chest wall necrosis requiring latissimus flap and skin grafting. The average number of days between the end of radiation therapy and documentation of reaction was 99.

Conclusions.
Ixabepilone chemotherapy may induce radiation recall and delayed wound healing when used shortly after the completion of external-beam radiotherapy. Significant clinical interactions have not been previously reported and merit further evaluation.
Molecular Characterization of Basal-Like and Non-Basal-Like Triple-Negative Breast Cancer
Authors: Prat Aleix , Adamo Barbara , Cheang Maggie C.U. , Anders Carey K. , Carey Lisa A. , Perou Charles M. 
Published: February 2013

Abstract

Learning Objectives
Contrast the definitions of TN and basal-like. Describe the undistinguishable global gene expression patterns of non-basal-like TN tumors versus non-TN tumors that are non-basal-like. Describe the relationship between TN heterogeneity and tumor heterogeneity plus microenvironmental heterogeneity.
Triple-negative (TN) and basal-like (BL) breast cancer definitions have been used interchangeably to identify breast cancers that lack expression of the hormone receptors and overexpression and/or amplification of HER2. However, both classifications show substantial discordance rates when compared to each other. Here, we molecularly characterize TN tumors and BL tumors, comparing and contrasting the results in terms of common patterns and distinct patterns for each. In total, when testing 412 TN and 473 BL tumors, 21.4% and 31.5% were identified as non-BL and non-TN, respectively. TN tumors identified as luminal or HER2-enriched (HER2E) showed undistinguishable overall gene expression profiles when compared versus luminal or HER2E tumors that were not TN. Similar findings were observed within BL tumors regardless of their TN status, which suggests that molecular subtype is preserved regardless of individual marker results. Interestingly, most TN tumors identified as HER2E showed low HER2 expression and lacked HER2 amplification, despite the similar overall gene expression profiles to HER2E tumors that were clinically HER2-positive. Lastly, additional genomic classifications were examined within TN and BL cancers, most of which were highly concordant with tumor intrinsic subtype. These results suggest that future clinical trials focused on TN disease should consider stratifying patients based upon BL versus non-BL gene expression profiles, which appears to be the main biological difference seen in patients with TN breast cancer.
Effects of High-Protein Versus High-Carbohydrate Diets on Markers of β-Cell Function, Oxidative Stress, Lipid Peroxidation, Proinflammatory Cytokines, and Adipokines in Obese, Premenopausal Women Without Diabetes
Authors: Kitabchi Abbas E. , McDaniel Kristin A. , Wan Jim Y. , Tylavsky Frances A. , Jacovino Crystal A. , Sands Chris W. , Nyenwe Ebenezer A. , Stentz Frankie B. 
Published: February 2013

OBJECTIVE
To study the effects of high-protein versus high-carbohydrate diets on various metabolic end points (glucoregulation, oxidative stress [dichlorofluorescein], lipid peroxidation [malondialdehyde], proinflammatory cytokines [tumor necrosis factor-α and interleukin-6], adipokines, and resting energy expenditure [REE]) with high protein–low carbohydrate (HP) and high carbohydrate–low protein (HC) diets at baseline and after 6 months of dietary intervention.

RESEARCH DESIGN AND METHODS
We recruited obese, premenopausal women aged 20–50 years with no diabetes or prediabetes who were randomized to HC (55% carbohydrates, 30% fat, and 15% protein) or HP (40% carbohydrates, 30% fat, and 30% protein) diets for 6 months. The diets were provided in prepackaged food, which provided 500 kcal restrictions per day. The above metabolic end points were measured with HP and HC diet at baseline and after 6 months of dietary intervention.

RESULTS
After 6 months of the HP versus HC diet (12 in each group), the following changes were significantly different by Wilcoxon rank sum test for the following parameters: dichlorofluorescein (−0.8 vs. −0.3 µmol/L, P &lt; 0.0001), malondialdehyde (−0.4 vs. −0.2 μmol/L, P = 0.0004), C-reactive protein (−2.1 vs. −0.8 mg/L, P = 0.0003), E-selectin (−8.6 vs. −3.7 ng/mL, P = 0.0007), adiponectin (1,284 vs. 504 ng/mL, P = 0.0011), tumor necrosis factor-α (−1.8 vs. −0.9 pg/mL, P &lt; 0.0001), IL-6 (−1.3 vs. −0.4 pg/mL, P &lt; 0.0001), free fatty acid (−0.12 vs. 0.16 mmol/L, P = 0.0002), REE (259 vs. 26 kcal, P &lt; 0.0001), insulin sensitivity (4 vs. 0.9, P &lt; 0.0001), and β-cell function (7.4 vs. 2.1, P &lt; 0.0001).

CONCLUSIONS
To our knowledge, this is the first report on the significant advantages of a 6-month hypocaloric HP diet versus hypocaloric HC diet on markers of β-cell function, oxidative stress, lipid peroxidation, proinflammatory cytokines, and adipokines in normal, obese females without diabetes.
The comparative gait effects of select walking surfaces using kinetic and emg analyses
Authors: Slaughter Stephen , Butler Patrick , Capozzella Heather , Nguyen Amanda , Hutcheson Lonn 
Published: February 2013

PurposeThis study investigated the EMG characteristics of muscles crossing the knee and the kinetics of the lower extremity during side-slope walking and other activities of daily living. We studied the difference in EMG data of the medial gastrocnemius and vastus lateralis muscles bilaterally and the relative rotation of the thigh to leg.MethodsEleven outdoor workers (47.3 ± 13.9 years old) were recruited for this study. Participants walked on a 0° flat surface, 5° and 10° side-sloped surfaces, 10° inclined treadmill and ascended stairs. The EMG activity and rotation about a vertical axis during stance phase were analyzed.ResultsExcept for minor variations, ANOVA showed no significant difference in EMG activity between the walking surfaces, furthermore, the relative rotation of thigh-to-leg showed little or no differences between the variables. Multivariate ANOVA showed p-values between 0.1602 and 0.9943 when comparing the EMG data of all side-sloped surfaces. The relative rotation of the thigh to the leg showed p-values of 0.7837 and 0.9813 when comparing the left 0° to 10° and right 0° to 10°, respectively.ConclusionsThe results of this study indirectly indicate that when considering rotation about a vertical axis and EMG activity, there is little difference in knee joint loading.
Famennian ostracods from the Istanbul zone (Gebze, Kocaeli, NW Turkey) and their paleogeographical relations
Authors: Nazik Atike , Çapkinoğlu Șenol , Șeker Emine 
Published: February 2013

Abstract
Famennian (Late Devonian) ostracods of the Thuringian Mega-Assemblage were recovered for the first time from three incomplete sections of the Ayineburnu Member of the Büyükada Formation in the Denizliköy area (Gebze, NW Turkey), which were sampled for conodonts. Conodont faunas define an interval extending from the Upper rhomboidea? or Lower marginifera Zone into the Middle expansa Zone of the standard Upper Devonian conodont zonation. The ostracod faunas found here consist of species mainly with thin-walls, long spines and often smooth surfaces such as Rectonaria, Tricornina, Orthonaria, Triplacera, Beckerhealdia, Timorhealdia, Bohemina, Paraberounella and Acratia. These taxa indicate faunal relationship with Thuringia and the Rhenish Massif in Germany, the Cantabrian Mountains and Pyrenees in Spain, Holy Cross Mountains in Poland, North Africa and China.