bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serving her Sentence: Gender and the Segregation of Carceral Space in Nineteenth‐Century America
Authors: Turner Felicity M. 
Published: February 2025

ABSTRACTDrawing on court cases, newspaper reports and pardon records from nineteenth‐century North Carolina in relation to infant murder and infanticide, this article complicates historical ideas about gender and incarceration by positing that in some circumstances, segregation in carceral spaces by virtue of gender served to benefit some women. Using the example of North Carolina – singular because of its lack of a centralised state prison in the years prior to the US Civil War – the article argues that segregation by gender advantaged white women, in particular, no matter how poor. Local communities accepted that such women, no matter the severity of their crime, could not be incarcerated with men. The absence of carceral spaces for white women then provided pathways to executive pardons for convicted women as there was nowhere to incarcerate them.
The Synergistic Impact of Digital Technology and Financial Systems on Sustainable Environment
Authors: Tahir Safdar Husain , Wang Xiaohui , Zulfiqar Muhammad , Ullah Muhammad Rizwan , Sajid Mushtaq A. 
Published: February 2025

ABSTRACTThis paper exclusively adds value to the state‐of‐the‐art literature, offering the combined impact of various conditions (variables) on environmental sustainability in the context of complexity theory. Unlike the conventional regression‐based research methods, the fuzzy set qualitative comparative analysis applies a novel configuration approach for analysing the data of 63 countries around the globe covering the period from 1990 to 2020. In addition, analytical induction is also used to diagnose existing patterns of solutions in the dataset. The input conditions are digital transformation, financial innovation, financial inclusion, foreign direct investment, and financial openness, while the outcome condition (variable) is an environmental sustainability. The necessary condition analysis shows no individual conditions indispensable for the outcome. However, sufficiency condition analysis discovers eight alternative solutions/ pathways, sufficient for the outcome. This study makes notable contributions to the existing body of knowledge that offers unique long‐term insights and practical solutions for academicians and policymakers working on sustainable environments worldwide, in particular.
Peanut skin polyphenols inhibit proliferation of leukemia cells in vitro, and its A‐type procyanidins selectively pass through a Caco‐2 intestinal barrier
Authors: Jantip Pornpat (Aom) , Singh Chandra K. , Klu Yaa Asantewaa Kafui , Ahmad Nihal , Bolling Bradley W. 
Published: February 2025

AbstractIncreased consumption of nuts is associated with reduced risk of some forms of cancer, including leukemia. Peanut skins are not typically retained during food processing but are a potential source of anticarcinogenic polyphenols. There are limited data about the antileukemic activity and bioavailability of peanut skin polyphenols. This study determined the polyphenol profile of raw peanut skin extract (PSE), its antiproliferative activity toward Jurkat cells, and intestinal bioavailability and metabolism using a Caco‐2 intestinal monolayer model. High‐resolution mass spectrometry (UHPLC–Q‐Orbitrap) was used to analyze PSE and extracts of PSE‐treated Jurkat cells to determine PSE polyphenols associated with antiproliferative activity. PSE reduced Jurkat cell viability, indicating its antiproliferative activity. PSE contained at least 63 polyphenols, including phenolic acids, proanthocyanidins, and prenylated flavonoids, among others. Multiple PSE polyphenols, particularly proanthocyanidins with A‐type bonds, interacted with Jurkat cells. In Caco‐2 cells, PSE intestinal bioavailability was limited to (+)‐catechin, quercetin, procyanidin A2, and tentatively procyanidin A1. Caco‐2 cells metabolized PSE polyphenols, including the methylation of A‐type procyanidin dimer. Thus, these cell‐based studies demonstrate that raw peanut skins contain intestinal bioavailable polyphenols with potential antileukemic properties. PSE polyphenols, including A‐type proanthocyanidins, were metabolized by intestinal cells. Thus, the antileukemic activity of PSE polyphenols is modulated by the bioavailability and metabolism of A‐type proanthocyanidins.Practical ApplicationRaw peanut skins are rich in polyphenols, including A‐type proanthocyanidins. Extracts of peanut skins inhibit the growth of cultured leukemia cells, and peanut A‐type proanthocyanidins are associated with this effect. Peanut skins are not typically retained in food processing, so further research and development are needed to recover or retain these compounds and document their health‐promoting activities in human research studies.
Role of IL‐34 in Tumors and Its Application to Regulate Inflammation
Authors: Igarashi Yuichi , Seino Ken‐ichiro 
Published: February 2025

ABSTRACTInterleukin (IL)‐34 is a relatively recently discovered cytokine which binds to colony‐stimulating factor‐1 receptor (CSF‐1R). So far, there has been no clear explanation as to why CSF‐1R requires two ligands. While CSF‐1 is ubiquitously expressed, the expression of IL‐34 is relatively restricted. However, it has been revealed that IL‐34 expression increases in various diseases and is associated with their pathology. Naturally, both IL‐34 and CSF‐1 stimulate CSF‐1R, thereby contributing to the differentiation of monocytes into macrophages. In many cases, the induced macrophages significantly influence the disease pathology. In particular, we have demonstrated that IL‐34 expression in cancer is deeply involved in tumor progression and therapeutic resistance. We have shown that the blockade of IL‐34 significantly improved therapeutic efficacy such as chemotherapy, radiotherapy, and immune checkpoint blockade against IL‐34‐expressing cancers. Recently, since macrophages induced by IL‐34 exhibit immunosuppressive properties, whereas IL‐34 can enhance inflammation, there is growing interest in actively regulating inflammation utilizing IL‐34. In this review article, we provide an overview of the characteristics and roles of IL‐34 and discuss how it could be applied to future diagnostics and therapeutics.
Single‐Nucleus RNA Sequencing and Spatial Transcriptomics for Squamous Cell Carcinoma Arising From Ovarian Mature Teratoma
Authors: Yoshida Kosuke , Yokoi Akira , Suzuki Hironori , Tamauchi Satoshi , Kitagawa Masami , Inami Eri , Nakayama Jun , Mori Yutaro , Okamoto Koji , Suzuki Yutaka , Yoshida Hiroshi , Kato Tomoyasu , Kajiyama Hiroaki , Yamamoto Yusuke 
Published: February 2025

ABSTRACTSquamous cell carcinoma arising from mature teratoma (SCC‐MT) is a rare ovarian malignancy. The detailed molecular pathology of SCC‐MT is not well understood. Moreover, the prognosis of the patients remains poor because no standard treatment has been established. In this study, we performed single‐nucleus RNA sequencing and spatial transcriptomics using clinical SCC‐MT samples to identify novel therapeutic candidates. snRNA‐seq revealed three epithelial cell clusters, of which one was significantly associated with epidermis and keratinocyte development. Moreover, spatial transcriptomics revealed that the epithelial‐mesenchymal transition was significantly inhibited, and the MYC and E2F targets were significantly activated in cancer spots on specimen sections. We focused on KLF5, which was one of the upregulated genes in cancer cells, and performed a functional analysis using NOSCC‐1, a cell line derived from an SCC‐MT. KLF5 downregulation significantly decreased cell proliferation and increased apoptosis. Furthermore, we previously identified miR‐145‐5p as a downregulated miRNA in SCC‐MT. We demonstrated that miR‐145‐5p overexpression attenuated cell proliferation and decreased KLF5 expression. In conclusion, through multi‐omics analyses, we identified unique gene expression profiles of SCC‐MT and determined a role for KLF5 in SCC‐MT development. Therefore, KLF5‐related factors may be novel therapeutic targets, and further studies are needed to improve the diagnosis and treatment of SCC‐MT.
Anti‐Inflammatory Compounds From Roots of Heracleum sphondylium subsp. cyclocarpum
Authors: Kurtul Ekin , Acıkara Özlem Bahadır , Ağören Büşra Karpuz , Akkol Esra Küpeli 
Published: February 2025

ABSTRACTHeracleum sphondylium subsp. cyclocarpum (K. Koch) P.H. Davis from Heracleum L. genus, which is one of the widest genera of the Apiaceae family and known as “Hogweed or Tavşancılotu”. This genus has a variety of traditional uses, including treating gastrointestinal, cardiovascular, gynecological, and cognitive disorders, skin problems, rheumatism, and inflammation. In particular, these plants are commonly used for inflammatory diseases. This research aimed to examine in detail the anti‐inflammatory properties of Heracleum sphondylium subsp. cyclocarpum roots. Bioactivity‐guided fractionation was used to isolate the active compounds. Carrageenan‐ and prostaglandin E2‐induced inflammation models were employed to test the activity. Dichloromethane and methanolic extracts of the plant material were tested for activity and found to be effective in inhibiting inflammation. The subfractions obtained by column chromatography were further evaluated for their activities. The active fractions were used to obtain responsible compounds by using semipreparative HPLC. Five coumarin derivatives were isolated and identified as heraclenol (1), byakangelicin (2), heraclenol‐3″‐O‐β‐glucoside (3), byakangelicin‐3″‐O‐β‐glucoside (4), and meranzin hydrate III (5). The isolated compounds were investigated for their anti‐inflammatory activities, and heraclenol‐3″‐O‐β‐glucoside was found to inhibit the carrageenan and prostaglandin E2‐induced edema significantly compared to the control group and have higher activity than the extracts.
Needs and Expectations of Nurse‐Led Digital Support Among Parents of Children in Child Health Care
Authors: Valan Lotha , Isaksson Ulf , Hörnsten Åsa 
Published: February 2025

ABSTRACTIntroductionSweden has an extensive national child health care programme (CHCP) implying that all parents are offered support to raise their children and support them for healthy development. The programme is today built on personal physical contacts and digital components unusual. Although the digital world could be frightening and insecure, it also has benefits, because it is not dependent on face‐to face meetings and is accessible more hours. In order to develop a digital channel to complement the CHPC, for the support of parents of children within child health care (CHC), parents' perspectives must be investigated. The aim of the study was therefore to describe parents' needs and expectations of digital support in the context of child health care.MethodsThe study had a qualitative approach using workshop discussions with parents as data. The interview data were analysed using qualitative content analysis.ResultsThe main theme highlights that parents expected that a digital support channel would be something that might strengthen them towards independence concerning the care of their children, in a positive way. However, they also felt that they needed personal support and that relationships with other parents and the child health care nurse were significant and meaningful. Another parental desire that emerged was that a future digital channel would facilitate and simplify access to care and they suggested having both planned and urgent times available for parents to book. The digital channel was expected to make this possible and be a good complement to the physical contacts the traditional child health care currently offers.Discussion/ConclusionsThe parents in this study believed that digital solutions could increase their parental power in relation to the care of their children. Examples were given as digital nurse‐led parent groups where parents with similar problems and experiences around their children could support each other and were expected to strengthen them over time. The parents stressed that a planned digital support channel also needs satisfactory solutions for both contact and response and have bookable digital meetings for both planned and urgent needs.
The impact of surgeon speciality on surgical outcomes following colorectal resection for endometriosis
Authors: Nasseri Yosef , Ma Rachel , Fani Negin , La Kristina , Solis‐Pazmino Paola , Xu Vincent , Siedhoff Matthew T. , Wright Kelly N. , Schneyer Rebecca , Hamilton Kacey M. , Barnajian Moshe , Meyer Raanan 
Published: February 2025

AbstractAimAn estimated 5%–25% of women with endometriosis have colorectal involvement. Colorectal resection is the most suitable surgical management for cases with large bowel infiltration. However, this method is also associated with the highest rate of postoperative complications. Data focusing on surgeon speciality and surgical outcomes are currently limited. The aim of this work was to evaluate the surgical characteristics and short‐term postoperative outcomes following colorectal resection for endometriosis according to surgeon speciality.MethodUsing the National Surgical Quality Improvement Program (NSQIP) database, we included women who underwent colorectal resection for endometriosis between 2012 and 2020. Surgeries by general/colorectal surgeons were compared with those by gynaecological surgeons. The primary outcome was major complications according to the Clavien–Dindo classification.ResultsAmong 745 colorectal resections, 82.3% were performed by general/colorectal surgeons and 17.7% by gynaecologists. Racial and ethnic characteristics differed between groups, but other baseline characteristics were comparable. General/colorectal surgeons performed fewer minimally invasive surgeries (29.9% vs. 58.3%, p < 0.001). General/colorectal surgery cases had lower rates of any postoperative complications and minor complications (14.8% vs. 29.5%, p < 0.001; 10.1% vs. 23.5%, p < 0.001), while major complication rates were similar. Multivariable regression showed no association between major complications and surgical speciality. In a propensity score‐matched analysis, no significant differences were found between the two cohorts.ConclusionMost colorectal resections are performed by general/colorectal surgeons while a minimally invasive approach is more common among gynaecologists. There were no significant differences in outcomes between the two groups after adjusting for confounding variables. This suggests considering a multidisciplinary or dual surgery team approach to deep infiltrative endometriosis requiring bowel resection.
Efficacy of inferior vesical vessels preservation in lateral lymph node dissection for rectal cancer: Short‐ and long‐term outcomes
Authors: Arai Sodai , Kagawa Hiroyasu , Shiomi Akio , Manabe Shoichi , Yamaoka Yusuke , Maeda Chikara , Tanaka Yusuke , Kasai Shunsuke , Notsu Akifumi , Kinugasa Yusuke 
Published: February 2025

AbstractAimLateral lymph node dissection (LLD) is performed for rectal cancer, with some cases requiring resection of the inferior vesical vessels (IVV). However, whether preservation or resection of the IVV affects urinary dysfunction (UD) as a major complication or local recurrence (LR) is unclear. Thus, we assessed the effect of IVV resection on the short‐ and long‐term outcomes of rectal cancer.MethodThis retrospective cohort study included patients who underwent robotic mesorectal excision with LLD between December 2011 and April 2021. The patients were divided into two groups based on preserved and resected IVV. Postoperative complications, including UD, and long‐term outcomes, including cumulative LR and cumulative lateral local recurrence (LLR), were evaluated.ResultsAmong 340 patients, 298 (87.6%) and 42 (12.4%) were included in the IVV preservation and resection groups, respectively. UD was more frequent (50% vs. 16.8%) in the IVV resection group than in the IVV preservation group (p < 0.01). In the multivariate analysis, IVV and autonomic nervous system resections were significantly associated with UD. The 3‐year LR was 4.0% and 5.7% in the IVV preservation and resection groups, respectively (p = 0.99). The 3‐year LLR was 2.1% and 0% in the IVV preservation and resection groups, respectively (p = 0.27).ConclusionIVV resection and autonomic nervous system resection were independent risk factors for UD in robotic LLD. IVV preservation, except in cases of necessity, improves patients’ quality of life and has favourable oncological outcomes.
Balancing ecotourism and wildlife management through a conservation behavior approach
Authors: Chock Rachel Y. , Bessa Eduardo , Arteaga‐Torres Josue David , Baker Liv , Buchholz Richard , Clucas Barbara , Nuñez Cassandra , Pinho Gabriela M. , Schulte Bruce A. , Blumstein Daniel T. , Kitheka Bernard , Allison Alexander G. , Arevalo J. Edgardo , Hamilton Debra A. , Monteza‐Moreno Claudio M. , Nute Laney H. , Rodríguez‐Fonseca Javier , Sandoval Luis , Stamn Jessica , Verdolin Jennifer L. , Von Hagen Lynn , Wehsener Jimmy W. , Seymoure Brett M. 
Published: February 2025

AbstractEcotourism promises to reconcile wildlife conservation and human development if negative impacts of human visitation and associated infrastructure can be minimized. Animal behavior studies can be used to identify individual and population responses to anthropogenic impacts before other fitness consequences are documented. With input from professionals in animal behavior and ecotourism, we identified key questions needed to better understand the impact of ecotourism on wildlife. Activity budgets, foraging, movement, stress, habituation, and reproduction were themes that emerged from our survey. We highlight promising research on these themes and identify remaining behavioral research questions about conserving wildlife in the context of ecotourism. Although ecotourism activities often have detrimental effects on animal behavior, we highlight research needs that can inform management and ecotourist education to improve human behavior to be more compatible with sustainable use of nature.
Gross Motor Function Measure‐66 Item Sets for use with infants and toddlers at high risk for cerebral palsy: Construct validity and responsiveness
Authors: Koziol Natalie A. , Butera Christiana D. , Hsu Lin‐Ya , Pereira Silvana Alves , Dusing Stacey C. 
Published: February 2025

AbstractAimTo evaluate the construct validity and responsiveness of the Gross Motor Function Measure‐66 Item Set (GMFM‐66‐IS), a standardized criterion‐referenced observational measure, for use with children younger than 24 months with or at high risk for cerebral palsy (CP).MethodNon‐experimental integrative data analysis was performed on secondary data from three clinical trials involving children with or at high risk for CP (n = 79, 42 males, mean corrected age = 11.3 months [SD = 4.9]), and one observational study of typically developing children (n = 32, 14 males, mean age = 5.7 months [SD = 0.8]). The GMFM‐66‐IS and comparator instrument (gross motor subtest from the Bayley Scales of Infant and Toddler Development, Third Edition [Bayley‐III] or Bayley Scales of Infant and Toddler Development, Fourth Edition [Bayley‐4], depending on the study) were administered at baseline and 3 months later. Comparator groups were based on neurological impairment, clinical rating of gross motor change, and CP status. Correlations (r) and regression‐adjusted standardized mean differences (Hedges' g) were computed.ResultsGMFM‐66‐IS and Bayley scores were correlated at baseline (r = 0.83), 3 months later (r = 0.88), and across time (r = 0.83). Children with mild impairment had higher mean GMFM‐66‐IS scores at baseline (g = 0.87) and 3 months later (g = 0.95). Children rated as demonstrating greater than expected gross motor change had larger mean GMFM‐66‐IS change scores than children demonstrating less than expected change (g = 0.62). Typically developing children had larger mean GMFM‐66‐IS change scores (g = 1.00).InterpretationGMFM‐66‐IS scores were supported by evidence of strong construct validity and moderate responsiveness.
Exploring healthcare professionals' attitudes to screening for disordered eating in type 1 diabetes
Authors: Fitzgerald Katie , Jones Christina , Partridge Helen , Rouse Lindsey , Satherley Rose‐Marie 
Published: February 2025

AbstractAimsEating disorders and disordered eating behaviours are prevalent among adults with type 1 diabetes, making early identification essential for improving health outcomes. Although screening tools exist to detect disordered eating in type 1 diabetes (T1DE), their application in clinical practice remains limited. This study investigates healthcare professionals' perspectives and attitudes towards screening for disordered eating in adult diabetes services.MethodologyThis qualitative study employed semi‐structured interviews with 13 healthcare professionals from adult diabetes services. Purposive sampling was used to ensure a broad range of healthcare professional viewpoints. The interviews centred on their perceptions of screening for disordered eating in type 1 diabetes.ResultsReflexive thematic analysis was used to identify four themes: (1) Uncertainty and Inevitabiltiy of T1DE: ‘A bit of a black hole’, (2) Asking about T1DE: ‘My fear is…am I overstepping the line’, (3) Patient‐provider relationships: ‘A backward step’, and (4) Lack of support for T1DE: ‘Where do you go?’. While healthcare professionals recognised the link between diabetes management and disordered eating, they lacked confidence in screening for these challenges due to limited time and the scarcity of specialist disordered eating resources for type 1 diabetes.ConclusionThis study highlights the challenges healthcare professionals face in screening for disordered eating in type 1 diabetes. By highlighting the need for enhanced training and clear clinical guidelines, this research suggests pathways to improve healthcare professional confidence in addressing these critical conversations with patients, ultimately supporting better health outcomes.
Alternative dosing regimens of GLP‐1 receptor agonists may reduce costs and maintain weight loss efficacy
Authors: Cengiz Anıl , Wu Calvin C. , Lawley Sean D. 
Published: February 2025

AbstractAimsTo discover alternative dosing regimens of incretin mimetics that simultaneously reduce costs and maintain weight loss efficacy. As a secondary objective, we used our results to explore how allocating a limited incretin mimetics budget could affect public health on a national scale.Materials and MethodsWe used mathematical modelling and simulation of semaglutide and tirzepatide to investigate dosing regimens which have not yet been studied clinically. For semaglutide, we used a recent pharmacokinetic (PK) and pharmacodynamic (PD) model. For tirzepatide, we used a recent PK model and modelled PD by reparameterizing the semaglutide PD model to fit tirzepatide clinical data.ResultsReducing dose frequency does not commensurately reduce weight loss. For example, merely switching from one dose per week (q1wk) to one dose every 2 weeks (q2wk) maintains roughly 75% of the weight loss. Furthermore, if the decrease in dose frequency involves an appropriate increase in dose size, then approximately 100% of the weight loss is maintained. In addition, we compared offering incretin mimetics to (1) a fraction of obese US adults with q1wk dosing versus (2) twice as many obese US adults with q2wk dosing. Though scenarios (1) and (2) require the same budget, our analysis suggests that (2) reduces national obesity and mortality to a much greater degree.ConclusionOur study highlights the potential utility of alternative dosing regimens of incretin mimetics. Compared with standard once‐weekly dosing, costs can be halved and weight loss maintained. These cost‐saving results have implications for patients, physicians, insurers, and governments.