bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Modular Synthesis of Novel 4‐Amino‐7,8‐dihydro‐1,6‐naphthyridin‐5‐(6H)‐ones as PDE4 Inhibitors.
Authors: Ferrer Manel , Roberts Richard S. , Sevilla Sara 
Published: December 2013

AbstractStarting with the DCC‐promoted condensation of Meldrum′s acid with N‐Boc protected ω‐amino acids a route to methylsulfonyl substituted naphthyridinones (X) is developed.
ChemInform Abstract: Synthesis of Phenanthridine and Its Analogues via Aerobic Ligand‐Free Domino Suzuki Coupling—Michael Addition Reaction Catalyzed by in situ Generated Palladium‐Nanoparticles in Water.
Authors: Ghosh Munmun , Ahmed Atiur , Dhara Shubhendu , Ray Jayanta K. 
Published: December 2013

AbstractThe synthesis of the title compounds is achieved from aryl bromides and 2‐aminophenylboronic acid under mild reaction conditions.
ChemInform Abstract: Facile Synthesis of Thiochromeno[2,3‐b]indol‐11(6H)‐ones and Pyrido[3′,2′:5,6]thiopyrano[2,3‐b]indol‐5(10H)‐ones.
Authors: Kiamehr Mostafa , Moghaddam Firouz Matloubi , Semeniuchenko Volodymyr , Villinger Alexander , Langer Peter , Iaroshenko Viktor O. 
Published: December 2013

AbstractA facile synthesis of the title compounds is achieved via regioselective cyclization of substrates (I) with 2‐chloronicotinoyl chloride or 2‐fluorobenzoyl chlorides, respectively.
ChemInform Abstract: A Novel One‐Pot Synthesis of 7‐Methoxy‐2‐arylthieno‐[3,2‐b]pyridine‐3‐ols in Domino Fashion.
Authors: Puvvala Srinu , Jadhav Vinod D. , Farooq Sheikh M. , Patro Balaram , Reddy Ch. Venkata Ramana 
Published: December 2013

AbstractA simple and efficient LDA‐promoted thioalkylation of picolinate ester with disulfides followed by intramolecular nucleophilic substitution affords the title compounds in a one‐pot fashion.
ChemInform Abstract: Nickel‐Catalyzed Decarboxylative Cycloaddition of Isatoic Anhydrides with Alkenes.
Authors: Sun Meng , Ma Yan‐Na , Li Ya‐Min , Tian Qiu‐Ping , Yang Shang‐Dong 
Published: December 2013

AbstractThe title reaction allows the synthesis of various quinoline derivatives.
ChemInform Abstract: A New Improved Method for the Synthesis of 2,4‐Diarylpyrimidines Starting from 2,2,2‐Trichloroethylideneacetophenones.
Authors: Guirado Antonio , Alarcon Enrique , Vicente Yesica , Andreu Raquel 
Published: December 2013

AbstractA novel synthetic method for pyrimidine synthesis is demonstrated using the reaction of 2,2,2‐trichloroethylideneacetophenones with enamides.
ChemInform Abstract: Catalyst‐Free Coupling of Indole Derivatives with 3,4‐Dihydroisoquinoline and Related Compounds.
Authors: Szatmari Istvan , Sas Judit , Fueloep Ferenc 
Published: December 2013

AbstractMicrowave assisted aza‐Friedel—Crafts reaction of indoles (I) with benzoazepine, thienopyridine, and isoquinoline derivatives provides 3‐substituted indoles.
ChemInform Abstract: Regio‐ and Diastereoselective Copper(I)‐Catalyzed Allylic Substitution of δ‐Hydroxy Allylic Chlorides by a Silicon Nucleophile.
Authors: Hazra Chinmoy K. , Irran Elisabeth , Oestreich Martin 
Published: December 2013

AbstractA new preparation of β‐hydroxy α‐chiral allylic silanes with the anti relative configuration by copper(I)‐catalyzed allylic silyl transfer is accomplished.
ChemInform Abstract: Abietane Diterpenes from Hyptis suaveolens.
Authors: Prawatsri Saowanee , Suksamrarn Apichart , Chindaduang Anon , Rukachaisirikul Thitima 
Published: December 2013

AbstractTitle compounds isosuaveolic acid (I), 14‐O‐methylsuaveolic acid (II), and 8α,9α‐epoxysuaveolic acid (III) are isolated from the whole title plant.
ChemInform Abstract: N‐Heteroarylation of Chiral α‐Aminoesters by Means of Palladium‐Catalyzed Buchwald—Hartwig Reaction.
Authors: Hammoud Hassan , Schmitt Martine , Blaise Emilie , Bihel Frederic , Bourguignon Jean‐Jacques 
Published: December 2013

AbstractThe title reaction allows an efficient approach to a number of N‐arylated α‐aminoesters which are putative peptidomimetics.
ChemInform Abstract: Synthesis of Highly Functionalized Enantiopure Halocyclopropanes Derived from Carbohydrates.
Authors: Rodriguez‐Solla Humberto , Concellon Carmen , del Amo Vicente , Diaz‐Pardo Ainhoa , Blanco Elena G. , Garcia‐Granda Santiago , Diaz M. Rosario , Llavona Ricardo , Soengas Raquel G. 
Published: December 2013

AbstractThe title synthesis can be stereospecifically carried out on E‐ or Z‐α,β‐unsaturated amides.
ChemInform Abstract: Chelating Cyclic Aminomethylphosphines and Their Transition Metal Complexes as a Promising Basis of Bioinspired Mimetic Catalysts
Authors: Karasik Andrey A. , Balueva Anna S. , Musina Elvira I. , Sinyashin Oleg G. 
Published: December 2013

AbstractReview: 79 refs.
Agent‐Based Simulation of Dynamic Accretion Processes
Authors: Kästner Wolfgang , Kittan Stefan 
Published: December 2013

AbstractEin Kühlmittelverluststörfall ist ein postuliertes Störfallszenario der Reaktorsicherheitsforschung bei dem davon ausgegangen wird, dass Isolationsmaterial infolge eines Lecks von Anlagenkomponenten freigesetzt wird. Um das Eindringen des Isolationsmaterials in den Reaktorkern zu minimieren, kann es mit Siebgittern zurückgehalten werden. Die dabei stattfindende Rückhaltung entspricht dem verfahrenstechnischen Fest/Flüssig‐Trennverfahren der Kuchenfiltration und hat in vielfältigen technischen Anwendungen eine hohe Relevanz. In dem vorliegenden Beitrag wird ein wissensbasiertes Modell zur Nachbildung des dynamischen Anlagerungsprozesses von Isolationsmaterial vorgestellt. Anhand eines Vergleiches zu einem bereits existierenden Modell wird das Potenzial der Methodik aufgezeigt.
Synapses lacking astrocyte appear in the amygdala during consolidation of pavlovian threat conditioning
Authors: Ostroff Linnaea E. , Manzur Mustfa K. , Cain Christopher K. , Ledoux Joseph E. 
Published: December 2013

ABSTRACTThere is growing evidence that astrocytes, long held to merely provide metabolic support in the adult brain, participate in both synaptic plasticity and learning and memory. Astrocytic processes are sometimes present at the synaptic cleft, suggesting that they might act directly at individual synapses. Associative learning induces synaptic plasticity and morphological changes at synapses in the lateral amygdala (LA). To determine whether astrocytic contacts are involved in these changes, we examined LA synapses after either threat conditioning (also called fear conditioning) or conditioned inhibition in adult rats by using serial section transmission electron microscopy (ssTEM) reconstructions. There was a transient increase in the density of synapses with no astrocytic contact after threat conditioning, especially on enlarged spines containing both polyribosomes and a spine apparatus. In contrast, synapses with astrocytic contacts were smaller after conditioned inhibition. This suggests that during memory consolidation astrocytic processes are absent if synapses are enlarging but present if they are shrinking. We measured the perimeter of each synapse and its degree of astrocyte coverage, and found that only about 20–30% of each synapse was ensheathed. The amount of synapse perimeter surrounded by astrocyte did not scale with synapse size, giving large synapses a disproportionately long astrocyte‐free perimeter and resulting in a net increase in astrocyte‐free perimeter after threat conditioning. Thus astrocytic processes do not mechanically isolate LA synapses, but may instead interact through local signaling, possibly via cell‐surface receptors. Our results suggest that contact with astrocytic processes opposes synapse growth during memory consolidation. J. Comp. Neurol. 522:2152–2163, 2014. © 2013 Wiley Periodicals, Inc.
Boosting the Resolution of 1H NMR Spectra by Homonuclear Broadband Decoupling
Authors: Meyer N. Helge , Zangger Klaus 
Published: December 2013

AbstractBroadband homonuclear decoupling of proton spectra, that is, the collapse of all multiplets into singlets, has the potential of boosting the resolution of 1H NMR spectra. Several methods have been described in the last 40 years to achieve this goal. Most of them can only be applied in the indirect dimension of multi‐dimensional NMR spectra or special data processing is necessary to yield decoupled 1D proton spectra. Recently, complete decoupling of proton spectra during acquisition has been introduced; this not only significantly reduced the experimental time to record these spectra, but also removed the need for any sophisticated processing schemes. Here we present an introduction and overview of the techniques and applications of broadband proton‐decoupled proton experiments.
Performance improvements of HCCA scheduling in V2R environments
Authors: Zhang Bing , Ma Maode , Liu Chunfeng , Shu Yantai 
Published: December 2013

SummaryThis paper addresses the issue of real‐time data transmission in vehicles to roadside environment by the hybrid coordination function controlled channel access (HCCA) scheme with Institute of Electrical and Electronics Engineers 802.11p protocol. The HCCA is one of the medium access protocols specified in 802.11p standard, which uses a polling scheme similar to the point coordination function to provide a reliable QoS. In this paper, we improve the HCCA polling scheme and design a new data transmission scheduling method. We also prepared a mathematical model to systematically evaluate the performance of the HCCA in terms of average delay. Moreover, we analyze the factors that could impact the average delay, throughput, and packet loss rate as well. The simulation results are compared with the original scheme specified in the standard. The simulation results demonstrate that the proposed delay model could estimate the average delay of the HCCA with a high precision, whereas the proposal of the enhancement of the HCCA has lower delay, lower loss rate, and higher throughput than the one specified in the standard. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis of Unnatural Phosphonosugar Analogues
Authors: Dayde Bénédicte , Pierra Claire , Gosselin Gilles , Surleraux Dominique , Ilagouma Amadou Tidjani , Laborde Coralie , Volle Jean‐Noel , Virieux David , Pirat Jean‐Luc 
Published: December 2013

AbstractThe first synthesis of new cyclic phosphonates (phostones), analogues of pentafuranoses containing a phosphorus atom in place of the anomeric carbon in the deoxyribose and deoxyxylose series, is described. Two methods, of respectively six and seven steps, were developed in parallel, and each gave the racemic phosphonosugars in good yields. Compounds analogous to the alpha and beta anomers were isolated and fully characterized by NMR spectroscopy.
Outcome of mantle cell lymphoma patients treated at a single institution over the past decade
Authors: Hitz Felicitas , Diem Stefan , Haile Sarah R. , Ess Silvia , Cerny Thomas , Mey Ulrich 
Published: December 2013

AbstractMantle cell lymphoma (MCL) is a rare non‐Hodgkin's lymphoma entity with a heterogeneous clinical presentation. Various therapeutic considerations in MCL for younger and elderly patients were used over the past decade. We retrospectively analyzed all 44 patients consecutively treated in a tertiary hospital between 2000 and 2010 with newly diagnosed MCL. Patient characteristics, treatment regimens and biological markers were evaluated with regard to overall survival (OS). Treatment regimens were categorized into internationally accepted intensive standard therapies and less intensive alternative treatment regimens given with palliative intent. Biological markers were correlated with clinical outcome by univariate analysis. The median age of the entire study group was 66 years (range: 42–88), with 23 (52%) patients ≥65 years. Thirty‐one (70%) patients received standard regimens, the remaining 13 (30%) patients were treated with other, less intensive regimens with palliative intent. With a median follow‐up of 5.25 years, the three‐year OS rate was 60% [95% confidence interval (CI) 0.47–0.77]. Patients treated with standard regimens had a three‐year survival rate of 77% (range: 64–94%). Of these, patients younger than 65 years were observed to have better OS (83% at 3 years; 95% CI 68–100%) than those older than 65 years (69% at 3 years; 95% CI 48–99%). In univariate analysis, the only parameters with a statistically significant prognostic impact on OS were absolute monocyte count as a continuous variable, lactate dehydrogenase and absolute lymphocyte count (>0.5 × 109/l) at diagnosis. In conclusion, our data of an unselected group of patients with newly diagnosed MCL treated at a single centre tertiary hospital are in line with results from larger randomized trials demonstrating an improved OS rate of younger as well as elderly MCL patients within the last decade. Copyright © 2013 John Wiley & Sons, Ltd.
Effects of central nervous system drugs on driving: speed variability versus standard deviation of lateral position as outcome measure of the on‐the‐road driving test
Authors: Verster Joris C. , Roth Thomas 
Published: December 2013

BackgroundThe on‐the‐road driving test in normal traffic is used to examine the impact of drugs on driving performance. This paper compares the sensitivity of standard deviation of lateral position (SDLP) and SD speed in detecting driving impairment.MethodsA literature search was conducted to identify studies applying the on‐the‐road driving test, examining the effects of anxiolytics, antidepressants, antihistamines, and hypnotics. The proportion of comparisons (treatment versus placebo) where a significant impairment was detected with SDLP and SD speed was compared.ResultsAbout 40% of 53 relevant papers did not report data on SD speed and/or SDLP. After placebo administration, the correlation between SDLP and SD speed was significant but did not explain much variance (r = 0.253, p = 0.0001). A significant correlation was found between ΔSDLP and ΔSD speed (treatment–placebo), explaining 48% of variance. When using SDLP as outcome measure, 67 significant treatment–placebo comparisons were found. Only 17 (25.4%) were significant when SD speed was used as outcome measure. Alternatively, for five treatment–placebo comparisons, a significant difference was found for SD speed but not for SDLP.ConclusionsStandard deviation of lateral position is a more sensitive outcome measure to detect driving impairment than speed variability. Copyright © 2013 John Wiley & Sons, Ltd.
The joint contribution of pain and insomnia to sickness absence and disability retirement: A register–linkage study among Norwegian and Finnish employees
Authors: Lallukka T. , Øverland S. , Haaramo P. , Saastamoinen P. , Bjorvatn B. , Sivertsen B. 
Published: December 2013

AbstractBackgroundPain and insomnia are both independently associated with work disability. Although pain and insomnia often co‐occur, their joint associations with subsequent sickness absence and disability retirement have not been studied. We aimed to examine these associations in two prospective occupational cohorts while considering key covariates.MethodsNorwegian Hordaland Health Study (n = 6892, 59% women) and Finnish Helsinki Health Study (n = 6060, 78% women) data were used. Those with only pain, only insomnia or both conditions at baseline were compared with those with no pain and no insomnia. Work disability outcomes were derived from national and employers' register data. Medically certified sickness absence spells lasting 2 weeks or more and all‐cause disability retirement were examined. Register‐based follow‐up was 4 years for sickness absence and 5 years for disability retirement. Covariates were sex, age, marital status, education, smoking, alcohol use, body mass index and blood pressure. Poisson and Cox regression models were fitted.ResultsBoth pain and insomnia were associated with subsequent sickness absence and disability retirement, but the associations were stronger for those reporting co‐morbid pain and insomnia with support for a synergistic interaction effect, particularly regarding disability retirement. The associations were largely similar in both cohorts and remained after full adjustments.ConclusionsThis study is the first to report the separate and combined effects of pain and insomnia on objective health outcomes. Common patterns observed in two separate cohorts suggest that the combination of pain and insomnia might be particularly relevant for subsequent disability retirement.
Regional analysis of femoral head perfusion following displaced fractures of the femoral neck
Authors: Dyke Jonathan P. , Lazaro Lionel E. , Hettrich Carolyn M. , Hentel Keith D. , Helfet David L. , Lorich Dean G. 
Published: December 2013

PurposeTo assess regional variations in the arterial and venous blood supply to the femoral head following displaced fracture of the femoral neck using dynamic contrast enhanced (DCE)‐MRI quadrant analysis.Materials and MethodsA total of 27 subjects with displaced femoral neck fractures were enrolled in the study. Quadrant specific DCE‐MRI perfusion analysis was performed on a 1.5 Tesla MRI scanner. Simultaneous imaging of control and displaced fractured hips was done for comparison.ResultsQuadrant specific decreases were found in the arterial (A (0.52 versus 0.27; P = 5.7E‐13), Akep (1.0/min−1 versus 0.41/min−1; P = 1.3E‐9) and venous (kel (0.05/min−1 versus −0.02/min−1; P = 5.1E‐5) supply to the femoral head between control and injured sides using a two‐factor analysis of variance test. The fractional perfusion (initial area under the curve) in the supero/inferolateral quadrants was 49% min/54% min, in the supero/inferomedial quadrants was 43% min/46% min and for the total femoral head was 39% min on the fracture versus control sides.ConclusionQuadrant specific decreases in arterial and venous perfusion on the fracture side were observed when compared with control. J. Magn. Reson. Imaging 2015;41:550–554.© 2013 Wiley Periodicals, Inc.
Automatic iceball segmentation with adapted shape priors for MRI‐guided cryoablation
Authors: Liu Xinyang , Tuncali Kemal , Wells William M. , Zientara Gary P. 
Published: December 2013

PurposeTo develop and evaluate an automatic segmentation method that extracts the 3D configuration of the ablation zone, the iceball, from images acquired during the freezing phase of MRI‐guided cryoablation.Materials and MethodsIntraprocedural images at 63 timepoints from 13 kidney tumor cryoablation procedures were examined retrospectively. The images were obtained using a 3 Tesla wide‐bore MRI scanner and axial HASTE sequence. Initialized with semiautomatically localized cryoprobes, the iceball was segmented automatically at each timepoint using the graph cut (GC) technique with adapted shape priors.ResultsThe average Dice Similarity Coefficients (DSC), compared with manual segmentations, were 0.88, 0.92, 0.92, 0.93, and 0.93 at 3, 6, 9, 12, and 15 min timepoints, respectively, and the average DSC of the total 63 segmentations was 0.92 ± 0.03. The proposed method improved the accuracy significantly compared with the approach without shape prior adaptation (P = 0.026). The number of probes involved in the procedure had no apparent influence on the segmentation results using our technique. The average computation time was 20 s, which was compatible with an intraprocedural setting.ConclusionOur automatic iceball segmentation method demonstrated high accuracy and robustness for practical use in monitoring the progress of MRI‐guided cryoablation. J. Magn. Reson. Imaging 2015;41:517–524.© 2013 Wiley Periodicals, Inc.
Clinical use of oxygen‐enhanced T1 mapping MRI of the lung: Reproducibility and impact of closed versus loose fit oxygen delivery system
Authors: Renne Julius , Lauermann Peer , Hinrichs Jan , Schönfeld Christian , Sorrentino Sajoscha , Gutberlet Marcel , Jakob Peter , Wacker Frank , Vogel‐Claussen Jens 
Published: December 2013

PurposeTo evaluate the reproducibility of oxygen‐enhanced magnetic resonance imaging (MRI), and the influence of different gas delivery methods, in a clinical environment.Materials and MethodsTwelve healthy volunteers were examined on two visits with an inversion recovery snapshot fast low angle shot sequence on a 1.5 T system. Coronal slices were obtained breathing room air as well as 100% oxygen with a flow rate of 15 L/min. For oxygen delivery a standard nontight face mask and a full closed air‐cushion face mask were used. T1 relaxation times and the oxygen transfer function (OTF) were calculated.ResultsThe mean T1 values did not change significantly between the two visits (P > 0.05). The T1 values breathing 100% oxygen obtained using the full closed mask were significantly lower (1093 ± 38 msec; P < 0.05) compared to the standard mask (1157 ± 52 msec). Accordingly, the OTF was significantly higher for the full closed mask (P < 0.05). The OTF changed significantly on the second visit using the standard mask (P < 0.05). The full closed mask showed lower interindividual variation for both the T1 values (3.5% vs. 4.5%) as well as the OTF (12.4% vs. 22.0%) and no difference of the OTF on the second visit (P > 0.05).ConclusionOxygen‐enhanced T1 mapping MRI produces reproducible data when using a full closed face mask. J. Magn. Reson. Imaging 2015;41:60–66. © 2013 Wiley Periodicals, Inc.
The Importance of the Default Mode Network in Creativity—A StructuralMRIStudy
Authors: Kühn Simone , Ritter Simone M. , Müller Barbara C. N. , van Baaren Rick B. , Brass Marcel , Dijksterhuis Ap 
Published: December 2013

AbstractAnecdotal reports as well as behavioral studies have suggested that creative performance benefits from unconscious processes. So far, however, little is known about how creative ideas arise from the brain. In the current study, we aimed to investigate the neural correlates of creativity by means of structuralMRIresearch. Given that unconscious and less controlled processes are important in creative thinking, structural brain research may find a positive correlation between well‐established creativity measures and cortical thickness in brain structures of the default mode network (i.e., the counterpart of the cognitive control network). Individuals performed the Alternative Uses task by which an individual's cognitive flexibility and the average uniqueness and average creativity of a participant's ideas were assessed. We computed optimized voxel‐based‐morphometry (VBM) to explore the correlation between inter‐individual differences in creativity and inter‐individual differences in gray matter volume. For all creativity measures, a positive correlation was found between creative performance and gray matter volume of the default mode network. These findings support the idea that the default mode network is important in creativity, and provide neurostructural support for the idea that unconscious forms of information processing are important in creativity. Theoretical and practical implications are discussed.