bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Kinesio Taping on Muscle Pain, Sprint Performance, and Flexibility in Recovery From Squat Exercise in Young Adult Women
Authors: Ozmen Tarik , Aydogmus Mert , Dogan Hanife , Acar Derya , Zoroglu Tuba , Willems Mark 
Published: January 2015

Context:Kinesio taping (KT) is a taping technique extensively used in rehabilitation of sports injuries; however, the effect of KT on delayed-onset muscle soreness is not entirely clear.Objectives:To investigate the effect of kinesio tape on the quadriceps femoris on muscle pain, flexibility, and sprint performance after squat exercise.Design:Crossover study.Setting:University research laboratory.Participants:19 female university students (age 21.0 ± 1.2 y, weight 53.0 ± 4.6 kg, height 164 ± 4 cm).Main Outcome Measures:Pressure-pain threshold for quadriceps femoris was recorded using pressure algometry. Quadriceps femoris flexibility was measured as the range of motion of knee flexion with a stainless steel goniometer. Sprint-speed measurements were conducted using photocells placed at 0 and 20 m. All participants completed both conditions (KT application and no KT application) after a 1-wk washout period. Measurements were taken at baseline and 48 h postexercise. For the KT condition, KT was applied immediately before the exercise protocol and remained on the skin for 48 h.Results:Squat exercise reduced flexibility and increased pain and sprint time compared with baseline. KT application resulted in similar sprint time and muscle pain as the no-KT condition but maintained flexibility compared with baseline.Conclusions:KT application immediately before squat exercise has no effect on muscle pain and short sprint performance but maintains muscle flexibility at 2 days of recovery.
Implications of Onicescu's informational energy in some fundamental physical models
Authors: Agop Maricel , Gavriluţ Alina , Rezuş Elena 
Published: January 2015

Correlating Shannon's maximum informational entropy variational principle with the constant value of Onicescu's informational energy, the uncertainty relations for canonical systems with SL(2R) invariance are obtained. The constant value of Onicescu's informational energy corresponds, through transitivity manifolds of the SL(2R) group, to the ergodic theorem and, in particular case of a linear oscillator, to a quantification condition. Specifying de Broglie's idea by a periodic field in a complex coordinate, it is proved that the oscillator synchronization group of the same ensemble is still an achievement of the SL(2R) (Barbilian's group). Integrally invoking the invariant functions through the simultaneous action of the two isomorphic SL(2R) groups, the uncertainty relations and Stoler group of synchronization among oscillators from different ensembles (i.e., the second quantification when the annihilation and creation operators refer to a linear oscillator) are obtained. Barbilian's group parameters are interpreted by means of a variational principle as field amplitudes of a stationary vacuum metric.
A Theory of Pricing Private Data
Authors: Li Chao , Li Daniel Yang , Miklau Gerome , Suciu Dan 
Published: January 2015

Personal data has value to both its owner and to institutions who would like to analyze it. Privacy mechanisms protect the owner's data while releasing to analysts noisy versions of aggregate query results. But such strict protections of the individual's data have not yet found wide use in practice. Instead, Internet companies, for example, commonly provide free services in return for valuable sensitive information from users, which they exploit and sometimes sell to third parties.
As awareness of the value of personal data increases, so has the drive to compensate the end-user for her private information. The idea of monetizing private data can improve over the narrower view of hiding private data, since it empowers individuals to control their data through financial means.
In this article we propose a theoretical framework for assigning prices to noisy query answers as a function of their accuracy, and for dividing the price amongst data owners who deserve compensation for their loss of privacy. Our framework adopts and extends key principles from both differential privacy and query pricing in data markets. We identify essential properties of the pricing function and micropayments, and characterize valid solutions.
Alembic
Authors: Holt Brandon , Briggs Preston , Ceze Luis , Oskin Mark 
Published: January 2015

Partitioned Global Address Space (PGAS) environments simplify writing parallel code for clusters because they make data movement implicit - dereferencing global pointers automatically moves data around. However, it does not free the programmer from needing to reason about locality - poor placement of data can lead to excessive and even unnecessary communication. For this reason, modern PGAS languages such as X10, Chapel, and UPC allow programmers to express data-layout constraints and explicitly move computation. This places an extra burden on the programmer, and is less effective for applications with limited or data-dependent locality (e.g., graph analytics).
This paper proposes Alembic, a new static analysis that frees programmers from having to manually move computation to exploit locality in PGAS programs. It works by determining regions of code that access the same cluster node, then transforming the code to migrate parts of the execution to increase the proportion of accesses to local data. We implement the analysis and transformation for C++ in LLVM and show that in irregular application kernels, Alembic can achieve 82% of the performance of hand-tuned communication (for comparison, naïve compiler-generated communication achieves only 13%).
Continuously measuring critical section pressure with the free-lunch profiler
Authors: David Florian , Thomas Gael , Lawall Julia , Muller Gilles 
Published: January 2015

Today, Java is regularly used to implement large multi-threaded server-class applications that use locks to protect access to shared data. However, understanding the impact of locks on the performance of a system is complex, and thus the use of locks can impede the progress of threads on configurations that were not anticipated by the developer, during specific phases of the execution.
In this paper, we propose Free Lunch, a new lock profiler for Java application servers, specifically designed to identify, in-vivo, phases where the progress of the threads is impeded by a lock. Free Lunch is designed around a new metric, critical section pressure (CSP), which directly correlates the progress of the threads to each of the locks. Using Free Lunch, we have identified phases of high CSP, which were hidden with other lock profilers, in the distributed Cassandra NoSQL database and in several applications from the DaCapo 9.12, the SPECjvm2008 and the SPECjbb2005 benchmark suites. Our evaluation of Free Lunch shows that its overhead is never greater than 6%, making it suitable for in-vivo use.
Determinacy in static analysis for jQuery
Authors: Andreasen Esben , Møller Anders 
Published: January 2015

Static analysis for JavaScript can potentially help programmers find errors early during development. Although much progress has been made on analysis techniques, a major obstacle is the prevalence of libraries, in particular jQuery, which apply programming patterns that have detrimental consequences on the analysis precision and performance. Previous work on dynamic determinacy analysis has demonstrated how information about program expressions that always resolve to a fixed value in some call context may lead to significant scalability improvements of static analysis for such code. We present a static dataflow analysis for JavaScript that infers and exploits determinacy information on-the-fly, to enable analysis of some of the most complex parts of jQuery. The analysis combines selective context and path sensitivity, constant propagation, and branch pruning, based on a systematic investigation of the main causes of analysis imprecision when using a more basic analysis.
The techniques are implemented in the TAJS analysis tool and evaluated on a collection of small programs that use jQuery. Our results show that the proposed analysis techniques boost both precision and performance, specifically for inferring type information and call graphs.
Accelerating iterators in optimizing AST interpreters
Authors: Zhang Wei , Larsen Per , Brunthaler Stefan , Franz Michael 
Published: January 2015

Generators offer an elegant way to express iterators. However, their performance has always been their Achilles heel and has prevented widespread adoption. We present techniques to efficiently implement and optimize generators.
We have implemented our optimizations in ZipPy, a modern, light-weight AST interpreter based Python 3 implementation targeting the Java virtual machine. Our implementation builds on a framework that optimizes AST interpreters using just-in-time compilation. In such a system, it is crucial that AST optimizations do not prevent subsequent optimizations. Our system was carefully designed to avoid this problem. We report an average speedup of 3.58x for generator-bound programs. As a result, using generators no longer has downsides and programmers are free to enjoy their upsides.
Atlas
Authors: Chakrabarti Dhruva R. , Boehm Hans-J. , Bhandari Kumud 
Published: January 2015

Non-volatile main memory, such as memristors or phase change memory, can revolutionize the way programs persist data. In-memory objects can themselves be persistent without the need for a separate persistent data storage format. However, the challenge is to ensure that such data remains consistent if a failure occurs during execution.
In this paper, we present our system, called Atlas, which adds durability semantics to lock-based code, typically allowing us to automatically maintain a globally consistent state even in the presence of failures. We identify failure-atomic sections of code based on existing critical sections and describe a log-based implementation that can be used to recover a consistent state after a failure. We discuss several subtle semantic issues and implementation tradeoffs. We confirm the ability to rapidly flush CPU caches as a core implementation bottleneck and suggest partial solutions. Experimental results confirm the practicality of our approach and provide insight into the overheads of such a system.
The larvae of West Palaearctic Eurylophella Tiensuu, 1935 (Ephemeroptera: Ephemerellidae), with description of a new species from Georgia
Authors: MARTYNOV ALEXANDER V. , PALATOV DMITRY M. , GODUNKO ROMAN J. 
Published: January 2015

Eurylophella korneyevi sp. nov. (larva) is described from the Kintrishi River within the Caucasus region of Georgia, Autonomous Republic of Adzharia. In addition to morphological data, biological and distribution data are also presented. The new species can be differentiated from other Eurylophella species by the shape of submedian tubercles on abdominal tergites, the structure of the dorsal subdivisions of the lower lamella of gills IV, and the shape and relative development of occipital tubercles. Distinguishing features of E. korneyevi sp. nov., Eurylophella karelica Tiensuu, 1935 and Eurylophella iberica Keffermüller & Da Terra, 1978 are given. The possibility of using chaetotaxy in the taxonomy of the genus is analyzed in detail for the West Palaearctic species of Eurylophella.
Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?
Authors: Wetz Anna J , Richardt Eva M , Wand Saskia , Kunze Nils , Schotola Hanna , Quintel Michael , Bräuer Anselm , Moerer Onnen 
Published: January 2015

Abstract
Introduction
Postoperative acute kidney injury (AKI) is a frequently observed complication after on-pump cardiac surgery (CS) and is associated with adverse patient outcomes. Early identification of patients at risk is essential for the prevention of AKI after CS. In this study, we analysed whether urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) combined with urine insulin-like growth factor binding protein 7 (IGFBP-7) ([TIMP-2] × [IGFBP-7]) is an adequate diagnostic test to identify early AKI after on-pump CS.

Methods
In 42 patients undergoing coronary artery bypass graft surgery, we surveyed individual risk factors for AKI and defined AKI by applying the Kidney Disease: Improving Global Outcomes (KDIGO) classification during the day of surgery and the following 2 days after surgery. Concentrations of urinary TIMP-2 multiplied by IGFBP-7 were recorded at four time points: at baseline pre-surgery, at the end of surgery, 4 hours after cardiopulmonary bypass (CPB) and at 8:00 am on the first postoperative day.

Results
In total, 38% of the patients experienced AKI. The results showed a median baseline [TIMP-2] × [IGFBP-7] concentration of 0.3 (ng/ml)2/1,000, decreasing at the end of surgery and then increasing at the next measurement point 4 hours after CPB and further on the first postoperative day. On the first postoperative day, patients with AKI had significantly higher concentrations of [TIMP-2] × [IGFBP-7]. On the day of surgery, the concentration did not significantly differ between patients classified as KDIGO 0 or KDIGO 1 or 2. Previously published cutoff points of 0.3 and 2 were not confirmed in our study cohort.

Conclusion
[TIMP-2] × [IGFBP-7] concentration can be used as a diagnostic test to identify patients at increased risk of AKI after CS on the first postoperative day. At earlier time points, no significant difference in [TIMP-2] × [IGFBP-7] concentration was found between patients classified as KDIGO 0 or KDIGO 1 or 2.

Trial registration
German Clinical Trials Register (DRKS) DRKS00005457. Registered 26 November 2013.
Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma
Authors: Zeng Ling , Du Juan , Gu Wei , Zhang An-qiang , Wang Hai-yan , Wen Da-lin , Qiu Lin , Yang Xue-tao , Sun Jian-hui , Zhang Mao , Hao Jiang , Jiang Jian-xin 
Published: January 2015

Abstract
Introduction
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study showed that rs1800625 (−429T/C) revealed a strong clinical relevance with sepsis morbidity rate and multiple organ dysfunction syndrome (MODS) in patients with major trauma. In this study, we enlarged the sample size, added two validation populations and examined the expression of RAGE on the surface of peripheral leukocytes to ex vivo lipopolysaccharide (LPS) stimulation in subjects with different genotypes.

Methods
Rs1800625 was genotyped using pyrosequencing in 837 Chinese Han patients with major trauma in Chongqing. We then validated the clinical relevance in 340 Zhejiang and 347 Yunnan patients. The expression of RAGE on the surface of peripheral blood mononuclear cells was measured by flow cytometric analysis.

Results
The results indicated that rs1800625 was significantly associated with sepsis morbidity rate and MODS in patients with major trauma in the Chongqing, Zhejiang and Yunnan districts. Patients with CC genotype had lower sepsis morbidity rate and MODS after major trauma. Furthermore, patients with CC genotype had significantly higher RAGE expression (P = 0.009).

Conclusions
The rs1800625 polymorphism is a functional single nucleotide polymorphism and confers host susceptibility to sepsis and MODS in patients with major trauma.
Relieving in-patient boredom in general hospitals: the evidence for intervention and practical ideas
Authors: Steele Rachel , Linsley Keith 
Published: January 2015

SummaryBoredom is highly prevalent among general hospital in-patients. Self-help strategies suit some patients, but for others hospitals need to stimulate opportunities for them to experience meaningful relationships and roles and a sense of control. In-patients' well-being and levels of boredom may be affected by no-smoking policies, hospital design, access to natural light, nature scenes and indoor or outdoor gardens. Alleviating boredom in elderly patients with reduced cognitive function may be particularly challenging. Healthcare professionals may face the wider challenge of fully engaging with patients' psychosocial needs, given the biomedical model that privileges the ‘traditional medical history’ over the more holistic communication model. Engaging with patients' psychosocial needs is consistent with managing their experience of 'sickness' rather than focusing on the narrower concept of ‘disease’.
Hong Kong: recent development of mental health services
Authors: Chan Wai-chi , Lam Linda Chiu-wa , Chen Eric Yu-Hai 
Published: January 2015

SummaryFrom a very deprived baseline, mental health services in Hong Kong have undergone some growth over the past decade. The number of inpatient beds for psychiatric treatment dropped by one-third, but the community mental health service expanded significantly. A number of low-resource phase-specific and age-specific treatment programmes were introduced, with promising initial results. However, there remain many challenges, including a serious shortage of well-trained mental health professionals. Much more investment in mental health workforce development is required to meet the service needs not only of today, but also of tomorrow.
Efficacy of cognitive bias modification interventions in anxiety
and depression: Meta-analysis
Authors: Cristea Ioana A. , Kok Robin N. , Cuijpers Pim 
Published: January 2015

BackgroundCognitive bias modification (CBM) interventions are strongly advocated in
research and clinical practice.AimsTo examine the efficiency of CBM for clinically relevant outcomes, along
with study quality, publication bias and potential moderators.MethodWe included randomised controlled trials (RCTs) of CBM interventions that
reported clinically relevant outcomes assessed with standardised
instruments.ResultsWe identified 49 trials and grouped outcomes into anxiety and depression.
Effect sizes were small considering all the samples, and mostly
non-significant for patient samples. Effect sizes became non-significant
when outliers were excluded and after adjustment for publication bias.
The quality of the RCTs was suboptimal.ConclusionsCBM may have small effects on mental health problems, but it is also very
well possible that there are no significant clinically relevant effects.
Research in this field is hampered by small and low-quality trials, and
by risk of publication bias. Many positive outcomes are driven by extreme
outliers.
Can psychedelic compounds play a part in drug dependence therapy?
Authors: Sessa Ben , Johnson Matthew W. 
Published: January 2015

SummaryAfter a 40-year hiatus there is now a revisiting of psychedelic drug therapy throughout psychiatry, with studies examining the drugs psilocybin, ketamine, ibogaine and ayahuasca in the treatment of drug dependence. Limitations to these therapies are both clinical and legal, but the possibility of improving outcomes for patients with substance dependency imposes an obligation to research this area.
Expanding the Phenotypic Spectrum and Variability of Endocrine Abnormalities Associated With TUBB3 E410K Syndrome
Authors: Balasubramanian Ravikumar , Chew Sheena , MacKinnon Sarah E. , Kang Peter B. , Andrews Caroline , Chan Wai-Man , Engle Elizabeth C. 
Published: January 2015

Context:
A heterozygous de novo c.1228G&gt;A mutation (E410K) in the TUBB3 gene encoding the neuronal-specific β-tubulin isotype 3 (TUBB3) causes the TUBB3 E410K syndrome characterized by congenital fibrosis of the extraocular muscles (CFEOM), facial weakness, intellectual and social disabilities, and Kallmann syndrome (anosmia with hypogonadotropic hypogonadism). All TUBB3 E410K subjects reported to date are sporadic cases.

Objective:
This study aimed to report the clinical, genetic, and molecular features of a familial presentation of the TUBB3 E410K syndrome.

Design:
Case report of a mother and three affected children with clinical features of the TUBB3 E410K syndrome.

Setting:
Academic Medical Center.

Main Outcome Measures:
Genetic analysis of the TUBB3 gene and clinical evaluation of endocrine and nonendocrine phenotypes.

Results:
A de novo TUBB3 c.1228G&gt;A mutation arose in a female proband who displayed CFEOM, facial weakness, intellectual and social disabilities, and anosmia. However, she underwent normal sexual development at puberty and had three spontaneous pregnancies with subsequent autosomal-dominant inheritance of the mutation by her three boys. All sons displayed nonendocrine features of the TUBB3 E410K syndrome similar to their mother but, in addition, had variable features suggestive of additional endocrine abnormalities.

Conclusions:
This first report of an autosomal-dominant inheritance of the TUBB3 c.1228G&gt;A mutation in a family provides new insights into the spectrum and variability of endocrine phenotypes associated with the TUBB3 E410K syndrome. These observations emphasize the need for appropriate clinical evaluation and complicate genetic counseling of patients and families with this syndrome.
Preparation and Characterization of Poly(vinylidene fluoride) (PVDF) Membrane
Authors: Woo Sahng Hyuck , Kim Kwang-Mo , Park Jinwon , Min Byoung Ryul 
Published: January 2015

Abstract
Poly(vinylidene fluoride) (PVDF) membrane blended with synthesized graft poly(vinylidene fluoride)-graft-poly(potassiosulfonatopropyl methacrylate) (PVDF-g-PSPMA) (A2) was prepared via a nonsolvent-induced phase separation for purpose of antifouling property enhancement. Blending of PVDF-g-PSPMA led to low water contact angle value in comparison with pristine PVDF membrane (A1). This property ultimately resulted in antifouling characteristics enhancement of the A2 membrane. For example, the A2 membrane displayed normalized flux (Jv/J0) as well as permeate flux superior to the A1 membrane.
Quantification of polysaccharides fixed to Gram stained slides using lactophenol cotton blue and digital image processing
Authors: Ericksen Bryan 
Published: January 2015

I discovered indigo rings and circles in Escherichia coli ATCC® 25922™ cultures when I added the non-specific polysaccharide stain lactophenol cotton blue to Gram stained slides sampled from 96-well plates used to measure quantitative growth kinetics (QGK) in virtual colony count antimicrobial assays. I attribute the dark blue staining to the presence of capsular polysaccharides and bacterial slime associated with clumps of cells. Since all bacterial cells are glycosylated, the majority of cells stain light blue. The contrast between dark and light staining is sufficient to enable a digital image processing thresholding technique to be quantitative for circular or ring-shaped structures that imply the presence of slime fixed to the glass. These polysaccharides indicate a possible mechanism of resistance to antimicrobial peptides such as defensins, lectins with high affinity for polysaccharides and glycosylated proteins. Adding lactophenol cotton blue to Gram stained slides is a quick and inexpensive way to screen cell cultures for bacterial slime, clumps and biofilms, revealing details of polysaccharide secretion that are missed using the Gram stain alone. Combined with QGK threshold times, the lactophenol cotton blue Gram stain followed by digital image processing provides quantitative information useful for quality control, environmental monitoring and detection of clumping environmental factors.