bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiofrequency ablation of the great saphenous vein, comparing one versus two treatment cycles for the proximal vein segment
Authors: Sufian S , Arnez A , Labropoulos N , Nguyen K , Satwah V , Marquez J , Chowla A , Lakhanpal S 
Published: October 2014

Objective To evaluate the results of radiofrequency ablation (RFA) of the great saphenous vein (GSV) using one versus two 20 s energy cycle treatment in the proximal 7 cm segment of the GSV. Methods All patients who underwent RFA of the GSV from 1 May 2013 to 30 September 2013 in eight of our vein centers were included. Duplex ultrasound scans (DUSs) were performed prior to treatment on all patients and 2–3 days, and 1 month after procedure. Demographic data, GSV diameters, and other relevant data were recorded. Clinical, Etiologic, Anatomic, Pathologic (CEAP) classification and Venous Clinical Severity Scores (VCSSs) were determined prior to ablation and one month later. Patients who developed endovenous heat induced thrombosis (EHIT) were followed till resolution. Results A total of 205 patients had one cycle treatment (group A) and 204 had two cycle treatment (group B). The two groups were comparable in their demography, CEAP classification, and VCSS scores. The rate of failure of ablation and incidence of EHIT were also not significantly different. The incidence of complications was low, <5% in both groups and all were minor. Conclusion Two cycle treatment of the proximal GSV for vein ablation does not improve the success rate of vein closure in the short term, compared to one cycle treatment. It also does not increase the risks of DVT, EHIT, major bleeding, and other complications. However, we do not know at what diameter two cycles may be superior to one cycle.
Duplex investigations in children: Are clinical signs in children with venous disorders relevant?
Authors: Birgitte Maessen-Visch M , Smeets L , van Vleuten C 
Published: October 2014

Objectives Ultra sound colored duplex sonography is the preferred method in diagnosing chronic venous disease. Data in children on incidence, indications, and results are lacking. Methods From the total of 9180 duplex investigations performed in our hospital from 2009 to 2012, data on indication and results of the investigation as well as patient characteristics were evaluated retrospectively for the proportion of pediatric patients. Results Duplex investigations were performed 49 times in 38 children (6–18 years), with an average of 1.3 times (1–6 times) per child. Forty percent showed abnormalities: 17 times deep venous thrombosis was suspected; deep venous thrombosis was objectified in 18%. In the 21 investigations performed for varicosis-related complaints, varicose veins or venous malformations were objectified in 57%. Edema was never a symptom of chronic venous disease. Conclusions Duplex investigation is not often performed in children. In children with established deep venous thrombosis, a family history with deep venous thrombosis is common. In general, edema was not seen in children with varicose veins and, therefore, does not seem a reliable clinical sign at young age.
Evaluation of Early Dexmedetomidine Addition to the Standard of Care for Severe Alcohol Withdrawal in the ICU
Authors: VanderWeide Luke A. , Foster Charles J. , MacLaren Robert , Kiser Tyree H. , Fish Douglas N. , Mueller Scott W. 
Published: October 2014

Purpose: This study evaluated the impact of dexmedetomidine (DEX) administration on benzodiazepine (BZD) requirements in intensive care unit (ICU) patients experiencing alcohol withdrawal syndrome (AWS). Methods: This trial included adults admitted to the ICU for >24 hours for AWS. Early DEX was defined as receiving DEX within 60 hours of hospital admission. The primary outcome was 12-hour BZD requirement from the inflection point or DEX initiation. Secondary outcomes included 24-hour BZD requirements, symptom control, ICU and hospital length of stay, and incidence and duration of mechanical ventilation. Safety outcomes included incidence of bradycardia and hypotension. Results: Twenty patients receiving DEX were matched to 22 control patients. The mean 12-hour change in BZD requirement was significantly different for DEX versus control (−20 vs −8.3 mg, P = .0455) with a trend toward significance at 24 hours (−29.6 vs −11 mg, P = .06). No significant differences were noted in other secondary outcomes. Patients receiving DEX experienced significantly more bradycardia than controls (35% vs 0%, P < .01) but not hypotension. Conclusions: This study suggests DEX is associated with a reduction in BZD requirement when utilized as adjunctive therapy for AWS. A larger prospective trial is needed to evaluate the clinical impact of DEX for AWS.
Workplace Lactation Support by New Jersey Employers following US Reasonable Break Time for Nursing Mothers Law
Authors: Bai Yeon K. , Gaits Susan I. , Wunderlich Shahla M. 
Published: October 2014

Background: Returning to an unsupportive work environment has been identified as a major reason for avoidance or early abandonment of breastfeeding among working mothers. Objective: This study aimed to examine the nature and extent of accommodations offered to breastfeeding employees among New Jersey employers since the US federal Reasonable Break Time for Nursing Mothers law enactment. Methods: A cross-sectional survey was conducted to measure current lactation support in the workplace in New Jersey. Using convenience sampling, the survey was sent to managerial personnel in hospitals and nonhospitals. The level of support was assessed on company policy, lactation room, and room amenity. A composite lactation amenity score was calculated based on responses about lactation room amenities. Results: Respondents (N = 51) completed a 22-item online questionnaire during fall 2011. The support level was compared by type of organization: hospital (n = 37) versus nonhospital (n = 14). The amenity score of hospitals was significantly higher than nonhospitals (1.44 vs 0.45, P = .002). The mean amenity score (score = 0.95) for all employers was far below comprehensive (score = 3.0). Compared to nonhospitals, hospitals were more likely to offer lactation rooms (81% vs 36%, P = .003), have their own breastfeeding policy (35.1% vs 7.1%, P = .01), and provide additional breastfeeding support (eg, education classes, resources; P < .05). Conclusion: Employers, regardless of the type of organization, need to improve their current practices and create equity of lactation support in the workplace.
Association of rs172378 C1q gene cluster polymorphism with lupus nephritis in Bulgarian patients
Authors: Radanova M , Vasilev V , Dimitrov T , Deliyska B , Ikonomov V , Ivanova D 
Published: October 2014

Introduction Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that can affect substantially any organ in the body. One of its most severe manifestations is lupus nephritis. Hereditary C1q deficiency is strongly related to SLE but there are very few and inconsistent studies exploring the single nucleotide polymorphisms (SNPs) of the C1q gene cluster in relation to the pathogenesis of SLE. In the present study we evaluated the possible association of gene variants in complement C1q gene cluster with susceptibility to lupus nephritis in a Bulgarian population, focusing on five previously associated with SLE SNPs in other populations. Materials and methods Thirty-eight patients with lupus nephritis and 185 healthy controls, all from Bulgaria, were genotyped for the five C1q SNPs, rs587585, rs292001, rs172378, rs294179 and rs631090, by quantitive real-time PCR methods. We also determined C1q serum levels of C1q and haemolytic activity of C1q in relation to C1q genotypes. Results Lupus nephritis patients and healthy controls had statistically similar frequencies of genotypes and alleles of rs587585, rs292001, rs294179 and rs631090 SNPs. Nevertheless, minor G allele in rs172378 was significantly overrepresented in lupus nephritis patients when compared with healthy controls (36% vs. 23%, odds ratio = 1.80, 95% confidence interval = 1.06–3.06, p = 0.029). The SNP rs292001 showed a trend towards lower serum C1q levels in healthy controls. Two SNPs – rs294179 and rs292001 – were in a linkage disequilibrium in patients and healthy controls with different power (healthy controls: r2 = 0.6526, D′ = 0.842; lupus nephritis patients: r2 = 0.491, D′ = 0.686). The haplotype C-A-A-T-T in the patient group was associated with lupus nephritis: 7.7% vs. 0.8%, odds ratio = 10.81, 95% confidence interval = 1.45–80.57, p = 0.002. Conclusions These results support the implication of the G allele in rs172378 as a risk factor for lupus nephritis in a homozygous status, at least for a Bulgarian population.
Effect of Syndesmosis Injury in SER IV (Weber B)–Type Ankle Fractures on Function and Incidence of Osteoarthritis
Authors: Kortekangas Tero , Flinkkilä Tapio , Niinimäki Jaakko , Lepojärvi Sannamari , Ohtonen Pasi , Savola Olli , Pakarinen Harri 
Published: October 2014

Background: Syndesmosis fixation of Lauge-Hansen SER IV, Weber B ankle fractures is controversial. This study compared a matched pair of SER IV patients with stress proven syndesmotic injuries with the same number without stress proven syndesmotic injury in terms of functional, pain, and radiologic result. Methods: The study was based on a RCT-study comparing syndesmotic transfixation to no fixation in SER IV (Weber B)–type ankle fractures. Twenty-four patients with a syndesmosis injury found on the intraoperative 7.5 Nm standardized external rotation test were compared to 24 patients with a stable syndesmosis. The pairs were matched by fracture morphology, sex, and age. The primary outcome measure was ankle function as assessed by the Olerud–Molander score. Weight-bearing plain radiographs and 3T MRI of the injured ankle were used to assess ankle joint congruity and osteoarthritis, according to Kellgren-Lawrence classification and cartilage defects. Results: The Olerud–Molander score was 86 in syndesmosis injury patients and 90 in patients with normal syndesmosis ( P = .28). The incidence of ankle joint osteoarthritis on plain radiographs was not significantly different between the groups (Grade I 5% vs 21%; Grade II 86% vs 75%; Grade III 9% vs 4%; P = .34). MRI scans showed TC joint cartilage defects in 54% of the patients: 12 (56%) in the syndesmosis injury group vs 13 (54%) in the group without syndesmosis injury ( P > .9). Conclusion: After 4 to 6 years of follow-up, clinical and radiologic outcome were not different in patients with syndesmosis injury compared to patients with stable syndesmosis in SER IV (Weber B)–type ankle fractures. Level of Evidence: Prognostic Level II, comparative study.
Assessing outcomes of adult oncology patients treated with linezolid versus daptomycin for bacteremia due to vancomycin-resistant Enterococcus
Authors: Patel Khilna , Kabir Rubiya , Ahmad Samrah , Allen Steven L 
Published: October 2014

Background The incidence and severity of vancomycin-resistant Enterococcus blood stream infections continue to rise and is a significant burden in the healthcare setting. Literature thus far is minimal regarding treatment outcomes in patients with malignancy and vancomycin-resistant Enterococcus bacteremia. Appropriate antibiotic selection is vital to treatment success due to high rates of resistance, limited antimicrobials and mortality in this patient population. We conducted this study to determine whether treatment outcomes differed between cancer patients treated with linezolid and those treated with daptomycin for vancomycin-resistant Enterococcus bacteremia. Methods This single-center, retrospective study included adult patients hospitalized on the oncology service with documented vancomycin-resistant Enterococcus faecium or Enterococcus faecalis bacteremia who received at least 48 h of either linezolid or daptomycin as primary treatment. Results A total of 65 patients were included in the analysis. Thirty-two patients received daptomycin as primary treatment, and 33 patients received linezolid as primary treatment. Twenty-six (76.5%) patients in the linezolid cohort versus 22 (71%) patients in the daptomycin cohort achieved microbiological cure ( p = 0.6141). Median length of stay in days (30 vs. 42, p = 0.0714) and mortality (7/32 (20.6%) vs. 8/33 (25.8%), p = 0.6180) were also similar between the linezolid and daptomycin treated patients, respectively. Conclusion No differences in microbiological cure, length of stay or mortality were identified between the groups. This study suggests that linezolid and daptomycin are each reasonable options for treating vancomycin-resistant Enterococcus bacteremia in oncology patients. Further prospective, randomized controlled trials are needed to assess the optimal treatment for vancomycin-resistant Enterococcus bacteremia in this patient population.
A Summary Description of OERC’s Research Funding Process
Authors: Albin Thomas J. 
Published: October 2014

The Office Ergonomics Research Committee (OERC) is a consortium of companies who work to advance ergonomic research and to disseminate research findings for use in designing and managing work places, systems, processes, and products. A unique aspect of OERC is its membership, which consists of both product designers and end-users. The resulting dialog between members results in a fertile interaction of ideas regarding gaps in the research base concerning computer-related work, which in turn shapes the OERC research agenda. During the past six years, OERC has funded 24 studies on various topics such as sit/stand work, mouse design, gestural input, lighting, and student computer use. In this presentation, the organization of OERC, its process for determining research priorities, the funding process, and the research that has been funded are described. OERC has proven to be an effective tool for the advancement and promotion of the human factors and ergonomics knowledge base regarding computer use.
Sense and Avoid
Authors: Chappell Sheryl L. , Palmer Everett A. 
Published: October 2014

This study explored the ability of operators to provide separation between three unmanned aircraft using basic cockpit traffic displays. Four groups of three general aviation, instrument-rated pilots flew cross-country flights controlling simulated twin-engine unmanned aircraft systems (UAS). They were required to maintain 2 nautical miles (nmi) horizontal and 500 ft vertical separation from all other aircraft. To examine the effect of two important safety factors, the flights were conducted with and without communication among the operators and with and without variable accuracy in the displayed traffic location due to degraded sensor quality. Twenty four different three-dimensional traffic conflict trajectories with three UASs, were repeated randomly for each of the four experimental conditions for each group. Of the 1152 aircraft encounters 12.8% were in violation of separation minimums. Eighteen of these were closer than 400 ft vertically or 1.6 nmi horizontally. The minimum separation of all aircraft pairs was 293 ft and 0.13 nmi. No difference in minimum separations was found due to the presence of communications, the variable accuracy of traffic position, or the participant group. The type and time of evasive maneuvers showed no effect when displayed horizontal position accuracy was variable. When operators were able to communicate and coordinate their maneuvers, the time to resolve the conflict was reduced. Participant groups varied significantly in: time of conflict resolution, frequency and type of maneuvers, control activity, reported amount of threat, confidence, satisfaction, and appraisal of the efficacy of their communications. The findings of this study serve as a benchmark for the development of sense and avoid procedures and minimum equipage standards for operating UASs in the airspace over the United States.
Effects of Mobile Technology Use on Walking
Authors: Perlmutter Sam , Cades David M. , Heller Michelle F. , Giachetti Robert , Arndt Steven R. , Sala Joseph B. 
Published: October 2014

Objective: The goal of this study was to evaluate the efficacy of combining cognitive and kinematic measurements to study the effects of mobile technology use on walking. Background: It has previously been shown that being distracted by a cell phone, or other mobile technology, can have a negative impact on activities such as crossing a street and may also alter gait patterns. While the negative effects of cell phone use on driving have been extensively studied, research into the distracted pedestrian is lacking. Method: Twelve adults walked down an office corridor without using a cell phone (BASELINE) and while performing a secondary cognitive task under two conditions. The secondary task involved answering simple multiplication problems through either text messaging (TEXT) or while talking on the phone (VOICE). Participants’ gait patterns were measured using a GAITRite gait pad LEGSys wearable wireless sensors. Results: In the TEXT condition, participants walked more slowly and had shorter strides. There was no significant difference between the VOICE and BASELINE condition. Participants answered more multiplication problems per trial in the VOICE condition as compared to the TEXT condition. Excluding typos, error rates for the multiplication problems were not significantly different between the TEXT and VOICE conditions. Conclusion: This study demonstrated that the effect of reading and responding to text messages on gait was able to be detected utilizing methods that do not require strictly sterile laboratory settings. This serves as a proof of concept for researchers to bring the study and evaluation of distracted walking into the naturalistic environments in which it actually occurs. Application: This proof of concept will serve as a roadmap towards moving the study of gait and distraction from simple observational studies in naturalistic environments to specific quantitative analysis of people performing real world tasks in real world settings.
Human Factors Engineering at the Transportation Security Administration
Authors: Greene Frances , Kudrick Bonnie , Muse Katherine 
Published: October 2014

The Transportation Security Administration (TSA) has three engineering psychologists within the Office of Security Capabilities (OSC) who address the human element for the Agency. While many activities and programs cannot be elaborated upon due to security restrictions, a few human factors activities will be reviewed. The human factors team is tasked with writing and reviewing acquisition documents, as well as participating in acquisition milestones that span the Acquisition Lifecycle Framework. The team also works to improve operational efficiency, training effectiveness and data mining efforts by examining how human factors and interactions can be optimized for various processes and procedures. The Office has several ongoing research efforts with a number of different performers to investigate a range of human-centered issues. For example, through the Risk-Based Security Workforce Transformation Group, hypotheses were presented regarding the specialization of Officers at the checkpoint: image analysis, passenger interface, and effective interaction. Industrial/Organizational psychologists match job task analysis competencies with batteries of assessments to test for attitudes, attributes and aptitudes that would be predictive of these competencies on the job. Additional human-centered efforts will be discussed throughout this paper.
Carbon nanodots interference with lactate dehydrogenase assay in human monocyte THP-1 cells
Authors: Wright Petra C , Qin Hu , Choi Martin MF , Chiu Norman HL , Jia Zhenquan 
Published: October 2014

Abstract

Background
Carbon nanodots (CD), a new class of carbon nanomaterials with sizes below 10 nm, have recently attracted wide attention due to their superiority in water solubility, chemical inertness, and resistance to photobleaching. As a result, CD has found important and wide applications in energy, catalysis, biological labeling, bioimaging and drug delivery. On the other hand, due to the lack of available toxicity data, there is a growing concern regarding the potential risks of CD. Hence, accurate assessment of the cytotoxicity of CD has become more important than ever before. The lactate dehydrogenase (LDH) assay is widely used to detect cytotoxicity of various nanoparticles including CD. Many recent studies used LDH assay to study the CD toxicity in various cells. However, these studies failed to further examine whether the CD were interfering with the LDH assay which would alter their findings.

Findings
This study investigated the possible interference of carbon nanodots on the LDH assay in human monocyte THP-1 cells. Monocytes are known to be involved in inflammable vascular diseases, and have been suggested to be the targets for CD exposure. In this study, the cytotoxicity of CD in concentrations ranging from 0.075 to 0.60 mg/mL, was determined by using the LDH assay. To validate the results of LDH assay, the cell counting method with trypan blue staining was used. With 24 hours incubation time, the cell viability of THP-1 was significantly decreased according to the trypan blue staining method. Whereas, in the LDH assay, the CD was found to interfere in a dose-dependent manner with the NADH absorbance measurements at 340 nm.

Conclusions
This study represents the first report on the negative interference of CD on LDH assay, and caution should be observed when evaluating the cytotoxicity of CD.
Adenomyoma of the small intestine a rare pathological lead point for intussusception in an infant
Authors: Bak You-Jung , Rolle Udo , Gfroerer Stefan , Fiegel Henning C 
Published: October 2014

Abstract

Introduction
Intussusception is a typical abdominal emergency in early childhood.

Case description
We report a case of an infant in the typically affected age group with an intussusception triggered by a rare benign intramural intestinal adenomyoma as a pathological lead point. The infant had the typical symptoms of a recurrent idiopathic ileocolic intussusception.

Discussion and evaluation
Idiopathic intussusception is frequent in the infant age group. Contrary to that, reports on pathological lead points for intussusceptions are sparse in the toddler age.

Conclusions
That case illustrates that even in intussusceptions in the typically affected age group, it is important to be aware of pathological lead points, especially if the intussusceptions are recurrent.
Excepting Myotis capaccinii, the wings' contribution to take-off performance does not correlate with foraging ecology in six species of insectivorous bat
Authors: Gardiner James D. , Altringham John D. , Papadatou Elena , Nudds Robert L. 
Published: October 2014

ABSTRACT
Take-off in bats is separated into two distinct phases: an initial jump and a subsequent wing powered acceleration. Here, using footage from a high-speed camera, the first comparative study of the performance during the wing induced phase of take-off in six insectivorous bat species is described. Despite distinct differences in foraging strategy, the mass specific power generated by the bats during wing induced take-off did not differ between species, with the exception of Myotis capaccinii. This suggests that differences in take-off performance may only be evident in bats that exhibit particularly unusual foraging strategies, such as the trawling behaviour of M. capaccinii – with differences in the remaining species only manifesting in subtler aspects of flight performance such as agility or manoeuvrability. The poorer take-off performance of M. capaccinii could be related to either a reduction in wing-stroke amplitude to stop the wings hitting the water's surface during foraging or perhaps an effect of having very large feet. No scaling relationship between body mass and mass-specific take-off power was found, which supports earlier research on birds and insects, suggesting that the mass-specific muscle power available for flight is broadly similar across a large range of body sizes and species.