bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stochastic Analysis Of An Incoherent Feedforward Genetic Motif
Authors: Platini Thierry , Soltani Mohammad , Singh Abhyudai 
Published: October 2015

AbstractGene products (RNAs, proteins) often occur at low molecular counts inside individual cells, and hence are subject to considerable random fluctuations (noise) in copy number over time. Not surprisingly, cells encode diverse regulatory mechanisms to buffer noise. One such mechanism is the incoherent feedforward circuit. We analyze a simplistic version of this circuit, where an upstream regulatorXaffects both the production and degradation of a proteinY. Thus, any random increase inX’s copy numbers would increase both production and degradation, keepingYlevels unchanged. To study its stochastic dynamics, we formulate this network into a mathematical model using the Chemical Master Equation formulation. We prove that if the functional dependence ofY’s production and degradation onXis similar, then the steady-distribution ofY’s copy numbers is independent ofX. To investigate how fluctuations inYpropagate downstream, a proteinZwhose production rate only depend onYis introduced. Intriguingly, results show that the extent of noise inZincreases with noise inX, in spite of the fact that the magnitude of noise inYis invariant ofX. Such counter intuitive results arise becauseXenhances the time-scale of fluctuations inY, which amplifies fluctuations in downstream processes. In summary, while feedforward systems can buffer a protein from noise in its upstream regulators, noise can propagate downstream due to changes in the time-scale of fluctuations.
Indel variant analysis of short-read sequencing data with Scalpel
Authors: Fang Han , Grabowska Ewa A. , Arora Kanika , Vacic Vladimir , Zody Michael C. , Iossifov Ivan , O’Rawe Jason A. , Wu Yiyang , Barron Laura T Jimenez , Rosenbaum Julie , Ronemus Michael , Lee Yoon-ha , Wang Zihua , Lyon Gholson J. , Wigler Michael , Schatz Michael C. , Narzisi Giuseppe 
Published: October 2015

ABSTRACTAs the second most common type of variations in the human genome, insertions and deletions (indels) have been linked to many diseases, but indels of more than a few bases are still challenging to discover from short-read sequencing data. Scalpel (http://scalpel.sourceforge.net) is open-source software for reliable indel detection based on the micro-assembly technique. To date, it has been successfully used to discover mutations in novel candidate genes for autism, and is extensively used in other large-scale studies of human diseases. This protocol gives an overview of the algorithm and describes how to use Scalpel to perform highly accurate indel calling from whole genome and exome sequencing data. We provide detailed instructions for an exemplary family-basedde novostudy, but we also characterize the other two supported modes of operation for single sample and somatic analysis. Indel normalization, visualization, and annotation of the mutations are also illustrated. Using a standard server, indel discovery and characterization in the exonic regions of the example sequencing data can be finished in ~6 hours after read mapping.
A conceptual review of risk communication network for protecting immigrant knowledge workers
Authors: Oh Namkyung , Beckett Julia 
Published: October 2015

Purpose– The purpose of this paper is to define immigrant knowledge workers (IKWs) as a vulnerable population in the urban emergency management context, and explored how to provide public safety services to IKWs. Due to nomadic features such as high mobility, spatio-temporality, and preferred autonomy, IKWs have difficulties in building required social ties with long-term residents in the urban emergency management system (UEMS). As such, IKWs are easily isolated and become vulnerable to disasters.Design/methodology/approach– This study introduced possible types of network structure, compared each structure’s weaknesses and strengths in terms of risk communication, and suggested the strategic use of brokers for effective risk communication with application of network analysis perspective.Findings– This study argued that the current space-based model causes tension in protecting NKWs and suggested the strategic use of brokers for the facilitated risk communication and for the protection of UKWs in more effective ways. The brokers in UEMS should pursue the core values of partnership, participation, and consultation in building mutual supportive channels within UEMS and the brokers should have sufficient cognitive capacity to avoid system fragmentation and collapse.Research limitations/implications– Due to the limitations as conceptual paper, sometimes it lacks empirical data to support the main arguments of this paper. To address this, the authors put that part as a suggestion for future studies.Originality/value– With the strategic use of brokers, UEMS would be more resilient and accountable in providing public safety services to its citizens.
A review of wildland fire smartphone applications
Authors: Kulemeka Owen 
Published: October 2015

Purpose– Fire management professionals are using smartphone applications to communicate information about wildland fires. The purpose of this paper is to examine English language wildland fire apps available to the general public to learn what information these apps contain and whether they match what are considered characteristics of well-designed apps.Design/methodology/approach– Content analysis of global app markets and other directories revealed ten relevant apps. Two coders installed the apps on identical smartphones and proceeded to review the apps’ content, features, and design characteristics.Findings– Results reveal that the ten English language wildland fire apps on the global app markets fall into three groups: apps that show nearby fires, emergency plan creation apps, and apps that inform on preparedness, response, and recovery. Strengths of these apps include that most load quickly on devices, they offer real-time contextual information, they can be used even when a device is offline, are easy to navigate, and do not utilize processor-intensive animation. Weaknesses include the fact that many lack a search engine, they do not explain how they protect sensitive user data, and they fail to reveal who authors of content are as well as when content was created or modified.Originality/value– Few studies have classified, analyzed content, or assessed the design of wildland fire apps. This study reveals that critical issues app designers should address include ensuring that apps contain privacy policies and disclaimers that app information is not supposed to replace live human advice.
Communication, dialogue and project management
Authors: Ziek Paul , Anderson J. Dwight 
Published: October 2015

Purpose– Project communication is overwhelmingly viewed as the proper and timely delivery of pertinent project information. The view of communication in this way misses the constitutive nature of communication. Communication is more than message exchange but a way that project managers generate the grounds for a project. The purpose of this paper is to explore how the communicative practices of project managers creates a dialogue with stakeholders that ultimately impacts the content, direction and outcome of a project.Design/methodology/approach– Semi-structured interviews were performed with project managers from the Project Management Office of a large international bank. The project managers were responsible for their own projects of varying size with scopes that included everything from marketing initiatives to heavily oriented technology projects.Findings– Overall, the project managers interviewed for the current project do not subscribe to the belief that communication is part of a constitutive dialogue. Instead, when discussing their overall views of communication, 82 percent of the interviewees took a transmission approach to the action. To that end, they believe that the goal of communication is to send clear, unambiguous and complete information.Originality/value– Unlike other studies about communication within the field of project management, the current study looks to uncover how communication is part of a constitutive dialogue between a project manager and project stakeholders. The researchers did not look just to understand the micro-level exchanges between project managers and stakeholders but how those exchanges enabled a sustained dialogue that shapes the scope and trajectory of a project.
Redefining governance: from confusion to certainty and clarity
Authors: McGrath Stephen Keith , Whitty Stephen Jonathan 
Published: October 2015

Purpose– The purpose of this paper is to resolve and remove from the governance arena in general and the project arena in particular, conflict which occurs when parties do not realise they have different meanings for common governance terms.Design/methodology/approach– Review literature on definitional confusion in general and on governance in particular and develop a method for defining an internally consistent group of terms, then apply this to a group of terms in the governance arena.Findings– Several important subjects commonly arranged under the governance banner do not actually constitute governance (strategy, behaviour, decision making).Research limitations/implications– Further work is necessary to remove similar confusion in other closely related areas, including power itself and authority as well as project and general management terms such as responsibility and accountability.Practical implications– Projects and business alike can potentially achieve significant improvements in efficiency and effectiveness through gaining consistency across current models, frameworks, policies and procedures thus reducing cross-boundary conflict.Social implications– Creation of a unifying feature within the project and management literature, shifting the understanding of the boundaries and limitations of governance. These definitions will help progress governance from complexity to simplicity, from an art to an understandable practice, from a concept that has been hijacked for partisan and political gain to a lean social tool which can be put to use for the benefit of organisations, whether public, charitable or private.Originality/value– The value is clarity – resulting in the avoidance of confusion and misunderstanding together with their consequent waste of time, resources and money.
Creativity and management control – the diversity of festival budgets
Authors: Knardal Per Ståle , Pettersen Inger Johanne 
Published: October 2015

Purpose
– The purpose of this paper is to investigate how the budget, when split into a network of projects, can act as a management tool to balance control with creativity.

Design/methodology/approach
– A case study is used to discuss the budget in a large Norwegian festival. Simons’ (1995) concept of interactive use of budgets is applied for the analysis of empirical findings. Especially, the authors focus on the design and use of the budget and how it is aligned with the specific characteristics of festivals as economic organizations.

Findings
– The findings support earlier research which focusses on the need to balance between control and dynamic changes to successfully manage festivals. This study gives a detailed knowledge on how managers use budgets to combine management control with creativity and dynamic adaptions.

Originality/value
– This study contributes to a detailed understanding of how managers can use budgets as tools to stabilize between uncertainty, creativity and control.
Managing competing logics through situational irony
Authors: Wikberg Erik , Bomark Niklas 
Published: October 2015

Purpose– The purpose of this paper is to extend the literature on how actors manage competing logics in an organizational field. The authors do so by introducing the concept of organizational irony to the literature on how to manage competing logics, and analyze a collaborative cultural project encompassing actors subjected to competing institutional logics.Design/methodology/approach– The case study is built on qualitative data from in-depth interviews, newspaper articles and observations.Findings– The authors describe and analyze a cultural project encompassing actors subjected to competing institutional logics and show how they responded to institutional pressures in their environment with the use of organizational irony. Thereby, the actors could collaborate with actors subjected to a competing institutional logic and still maintain adherence to their respective institutional logic.Research limitations/implications– Most studies of how to manage competing logics asserts that one logic will prevail over a competing one, either through “battles” or gradual dominance (Reay and Hinings, 2009). This study supports and adds to Reay and Hinings’ (2009) finding that actors also can collaborate and maintain adherence to their respective logic under such circumstances. In particular, it supports two identified mechanisms of how this can be achieved, namely, to separate decisions and to jointly innovate in experimental sites. It also adds to these mechanisms by showing that this can be done through the use of organizational irony. The authors only study one cultural project in one organizational field. It remains unclear if these findings are common in other cultural projects or in other organizational field, and the authors therefore encourage other researchers to extend or challenge the findings of this study.Practical implications– The authors believe that the analysis and findings can be useful for politicians to take into account and address either to minimize the risk of organizational irony or on the contrary encourage it as a source of reflexive critique of society and cultural politics. The authors also believe that the response of organizational irony to institutional pressures broadens the acting space of cultural actors, provide media and critics with an analytical tool to analyze and deconstruct practices that otherwise would risk to be silenced or neglected. Finally, the authors believe that an analysis of organizational irony has the potential to make people attend to contradictions and multiple meanings in the artworks under study in a novel way.Originality/value– The paper provides an intriguing and complex empirical case to demonstrate how actors manage competing logics in an organizational field through the production of organizational irony. The authors believe that its theoretical contributions and practical implications can inspire future research on how paradoxes can be managed through the use of organizational irony in other projects and organizational fields.
Poverty and earning compulsions for the family have pushed children out of schools
Authors: Banik Arindam , Neogi Debasis 
Published: October 2015

Purpose
– The purpose of this paper is to examine factors that explain dropout of children from primary schools in Lohit district of Arunachal Pradesh, India.

Design/methodology/approach
– The field survey was carried out in two phases, one, during January to April of 2010 and two, between August and November of 2011. The entire research work is based on stratified random sampling. The population in Lohit district is a set of tribal and non-tribal (mostly general) people. The district has two major tribes – Mishmi and Khamti.

Findings
– The authors find that children dropout of school is affected by number of factors such as earning compulsions, household work, access to school, school time not suitable and parental unawareness.

Research limitations/implications
– It is imperative to mention here that “earning compulsion” can be described only as a derivative of the major problem of abject poverty.

Practical implications
– By highlighting the role of appropriate intervention as well as incapacitation, the authors believe that the findings presented above shed light on some important factors that explain dropouts.

Social implications
– The evidence provided in this paper underscores the importance of social interactions in analysing individual outcomes.

Originality/value
– The findings may have significant bearings in reducing dropout rates in India.
Multivariate robust estimation of inequality indices
Authors: Lara Alvarez Jorge 
Published: October 2015

Purpose
– The data employed to measure income inequality usually come from household surveys, which commonly suffer from atypical observations such as outliers and contamination points. This is of importance since a single atypical observation can make classical inequality indices totally uninformative. To deal with this problem, robust univariate parametric or ad hoc procedures are commonly used; however, neither is fully satisfactory. The purpose of this paper is to propose a methodology to deal with this problem.

Design/methodology/approach
– The author propose two robust procedures to estimate inequality indices that can use all the information from a data set, and neither of them rely on a parametric distributional assumption. The methodology performs well irrespectively of the size and quality of the data set.

Findings
– Applying these methods to household data for UK (1979) and Mexico (2006 and 2011), the author find that for UK data the Gini, Coefficient of Variation and Theil Inequality Indices are over estimated by between 0.02 and 0.04, while in the case of Mexico the same indices are over estimated more deeply, between 0.1 and almost 0.4. The relevance of including atypical observations that follow the linear pattern of the data are shown using the data from Mexico (2011).

Research limitations/implications
– The methodology has two main limitations: the procedures are not able to identify a bad leverage outlier from a contamination point; and in the case that the data has no atypical observations, the procedures will tag as atypical a very small fraction of observations.

Social implications
– A reduction in the estimate of inequality has important consequences from a policy maker perspective. First, ceteris paribus, the optimal amount of resources destinated to directly address inequality/poverty. Those “extra” resources can be destinated to promote growth. Notice that this is a direct consequence of having a more egalitarian economy than previously thought, this is due to the fact that poor people will actually enjoy a bigger share of any national income increment. This also implies that, in order to reduce poverty, public policies should focus more on economic growth.

Originality/value
– To the knowledge, in the inequality literature this is the first methodology that is able to identify outliers and contamination points in more than one direction. That is, not only at the tails of the distribution, but on the whole marginal distribution of income. This is possible via the use of other variables related to income.
A new simple shear deformation theory for free vibration analysis of isotropic and FG plates under different boundary conditions
Authors: Mahi Amale , Adda Bedia El Abbas , Tounsi Abdelouahed , Benkhedda Amina 
Published: October 2015

Purpose– A new simple parametric shear deformation theory applicable to isotropic and functionally graded plates is developed. This new theory has five degrees of freedom, provides parabolic transverse shear strains across the thickness direction and hence, it does not need shear correction factor. Moreover, zero-traction boundary conditions on the top and bottom surfaces of the plate are satisfied rigorously. The paper aims to discuss these issues.Design/methodology/approach– Material properties are temperature-dependent and vary continuously through the thickness according to a power law distribution. The plate is assumed to be initially stressed by a temperature rise through the thickness. The energy functional of the system is obtained using Hamilton’s principle. Free vibration frequencies are then calculated using a set of characteristic orthogonal polynomials and by applying Ritz method for different boundary conditions.Findings– In the light of good performance of the present theory for all boundary conditions considered, it can be considered as an excellent alternative to some two-dimensional (2D) theories for approximating the tedious and time consuming three-dimensional plate problems.Originality/value– To the best of the authors’ knowledge and according to literature survey, almost all published higher order shear deformation theories have been limited to simply supported boundary conditions and without taking into account the thermal stresses effects. The existing 2D shear deformation theories of Reddy, Karama and Touratier can be easily recovered. Furthermore, this feature can be highly appreciated in an iterative design process where a large number of derived plate models can be tested by selecting only two parameters in a simple polynomial function which is computationally efficient. Finally, new results are presented to show the effect of material variation, and temperature rise on natural frequencies of the FG plate for different boundary conditions.
Multi objective optimization of ECG process under fuzzy environment
Authors: Bose G K 
Published: October 2015

Purpose– In the present research work electrochemical grinding (ECG) process is applied to machine Al2O3/Al interpenetrating phase composite. The purpose of this paper is to present a new approach to optimize the ECG process parameters while machining alumina-aluminum (Al2O3– Al) interpenetrating phase composites (IPC) used in automotive, aircraft and manufacture of space ships applying Taguchi-based experimental studies and fuzzy multi-criteria decision-making techniques.Design/methodology/approach– The present work identifies the process variables that have significant consequences during ECG of Al2O3/Al IPC. The Taguchi L9orthogonal array is selected for design of experiments and the analysis is carried out following signal to noise ratio. The analysis of variance is carried out to establish the factors that significantly influence the responses. The present work also investigates the multi objective optimization of ECG process parameters using VIseKriterijumsa Optimizacija I Kompromisno Resenje (VIKOR) and Grey relational analysis (GRA) to establish the reference ranking from a set of alternatives in the presence of conflicting criteria.Findings– Material removal rate, surface finish, overcut and cutting force are shown to depend on the type of electrolyte, supply voltage, depth of cut and electrolyte flow rate. It is found that voltage and electrolyte concentration are important. The optimal machining parameter combination for ECG process is determined using fuzzy set theory, VIKOR and GRA. Substantial improvement in machining performance takes place.Practical implications– A variety of manufacturing techniques are available for processing of Al2O3– Al metal matrix composites. Generally manufacturers favor low cost modus operandi. Therefore ECG process is the best alternative for processing of MMCs in the present commercial sectors. The experimental investigation approach can act as useful and an efficient guideline for manufacturing.Originality/value– The characteristic features of the ECG process are reflected through Taguchi design-based experimental studies with various process parametric combinations. Application of multi-response optimization technique for evaluation of best parametric combination for machining Al2O3– Al IPC material using ECG process is a first-of-its-kind approach in literature.