bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building a valid structural model in a triangle zone: An example from the Neuquén fold and thrust belt, Argentina
Authors: Zamora-Valcarce Gonzalo , Zapata Tomás 
Published: October 2015

Structural modeling and systematic analysis are necessary in complex areas even before seismic interpretation. Seismic data in these zones usually show poor-quality images of the geologic elements. Therefore, a detailed analysis of the available information (e.g., seismic, previous wells, and surface geology) is needed to build a comprehensive structural model to constrain the seismic interpretation. Although a restorable structural cross section is not necessarily the unique solution, it is a valid interpretation to begin with, which can be tested against additional information. As an example, a structural profile interpretation in the Agrio fold and thrust belt of the Neuquén Basin, northeastern Argentina, is presented and described as invalid on the basis of several unrestorable geometric components. This led to the reevaluation of the structure to understand its possible exploratory potential. Integration of different data such as regional structural styles inferred fault trajectories from seismic reflection termination patterns, synorogenic deposit geometries in seismic, and surface geology, dipmeter data to identify the presence and location of fault position and vergence of the fold axis, and a kinematic forward model, resulted in a new restorable structural model. The new interpretation proposes a “broken triangle zone” framed by two opposite surface anticlines with the same detachment level, later faulted by a basement fault. The interpreted model suggests at least two phases of deformation (1) a thin-skinned phase with the two opposite anticlines sharing the same detachment level that is responsible for about 80% of the shortening and (2) a thick-skinned phase from an east-verging basement fault, transporting the western anticline and crosscutting the eastern anticline, that is responsible for 20% of the shortening and the synorogenic deposits at the frontal region. This new interpretation defined a new exploration prospect drilled by a wildcat well, which validated the interpretation and model predictions.
GEMMs as preclinical models for testing pancreatic cancer therapies
Authors: Gopinathan Aarthi , Morton Jennifer P. , Jodrell Duncan I. , Sansom Owen J. 
Published: October 2015

ABSTRACT
Pancreatic ductal adenocarcinoma is the most common form of pancreatic tumour, with a very limited survival rate and currently no available disease-modifying treatments. Despite recent advances in the production of genetically engineered mouse models (GEMMs), the development of new therapies for pancreatic cancer is still hampered by a lack of reliable and predictive preclinical animal models for this disease. Preclinical models are vitally important for assessing therapies in the first stages of the drug development pipeline, prior to their transition to the clinical arena. GEMMs carry mutations in genes that are associated with specific human diseases and they can thus accurately mimic the genetic, phenotypic and physiological aspects of human pathologies. Here, we discuss different GEMMs of human pancreatic cancer, with a focus on the Lox-Stop-Lox (LSL)-KrasG12D; LSL-Trp53R172H; Pdx1-cre (KPC) model, one of the most widely used preclinical models for this disease. We describe its application in preclinical research, highlighting its advantages and disadvantages, its potential for predicting clinical outcomes in humans and the factors that can affect such outcomes, and, finally, future developments that could advance the discovery of new therapies for pancreatic cancer.
From bench to patient: model systems in drug discovery
Authors: Breyer Matthew D. , Look A. Thomas , Cifra Alessandra 
Published: October 2015

ABSTRACT
Model systems, including laboratory animals, microorganisms, and cell- and tissue-based systems, are central to the discovery and development of new and better drugs for the treatment of human disease. In this issue, Disease Models & Mechanisms launches a Special Collection that illustrates the contribution of model systems to drug discovery and optimisation across multiple disease areas. This collection includes reviews, Editorials, interviews with leading scientists with a foot in both academia and industry, and original research articles reporting new and important insights into disease therapeutics. This Editorial provides a summary of the collection's current contents, highlighting the impact of multiple model systems in moving new discoveries from the laboratory bench to the patients' bedsides.
Practice Prize Winner—ECO: Entega’s Profitable New Customer Acquisition on Online Price Comparison Sites
Authors: Natter Martin , Ozimec Ana-Marija , Kim Ju-Young 
Published: October 2015

Market liberalization of the German household electricity market has led to an excessive number of competitors (1,150 electricity providers) and volatile price dynamics on price comparison sites. To date, providers that are struggling to achieve a top ranking on price comparison sites do not appear to implement a consistent or elaborate strategy for attracting customers. We developed a pricing tool, Electricity Contract Optimization (ECO), that addresses this highly competitive market situation by integrating various available data sources, such as data from price comparison sites, demographic data, and regional sales or cost data. ECO sets regionally varying one-time bonuses to attract new customers on price comparison sites with the goal of optimizing sales and profit targets or optimally allocating sales budgets. Based on two field experiments, we demonstrate that ECO’s optimization procedure reduces ENTEGA yearly sales costs for new customer business, on average, by 35% relative to previously used pricing heuristics. ENTEGA uses ECO monthly to analyze different scenarios or to set prices and one-time bonuses on price comparison sites. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mksc.2015.0943 .
Portability and pedagogy: The bounded short stories in Stephen Marche’s Shining at the Bottom of the Sea
Authors: Gordon Neta 
Published: October 2015

Abstract
Beginning with a discussion of Ian Reid’s concept of the circumtext, as well as Gerard Genette’s idea of the paratext as ‘threshold,’ this article considers the matter of the short story’s potential for portability via an examination of Stephen Marche’s Shining at the Bottom of the Sea. Marche’s text highlights the tension between reading fiction ‘as fiction’ versus ‘as anthropological data,’ especially as that tension emerges in Canadian postcolonial literary studies about pedagogy. My aim is to examine Marche’s postmodern parody as a paradoxical challenge to the idea of the short-story collection as an ‘open book,’ a challenge that confronts the notion of history as discourse; as I will argue, the multiple histories emerging as sites of exploration in Shining at the Bottom of the Sea includes histories of political violence and struggle, histories of reading and teaching, and histories of genre.
Incarceration, focalization and narration: Adapting the two selves in ‘Boys and Girls’1
Authors: Ue Tom 
Published: October 2015

Abstract
Criticism on Alice Munro has neglected many adaptations of her writing. This article offers a corrective by examining Don McBrearty’s 25-minute short film ‘Boys and Girls’ (1983), based on the story of the same title. In this article, I explore how Munro’s treatment of metanarration and her preoccupation with issues of perspective – as revealed, for instance, by the story’s gestures towards its being focalized from the perspective of an unnamed, first-person narrator and that it is relayed to us in retrospect – are imbricated in the narrative structure of McBrearty’s adaptation. I begin by exploring Munro’s concerns about narration and gender before examining McBrearty’s project and analysing how it not only replicates but also offers a fresh perspective on the short story.
‘The voice is the guide to the experience as well as the experience itself’: An interview with non zero one
Authors: Thomaidis Konstantinos , Butcher Sarah 
Published: October 2015

Abstract
Since 2009, non zero one – a London-based collective of artists with a background and interest in theatre but working across media and performance disciplines – has devised a series of unexpected, challenging but also light-hearted and inviting experiences of immersion. Whilst embracing a variety of techniques and contemporary media, one of the key features of the company’s work is the exploration of audience interaction through the use of headphones, typically in promenade and/ or site-specific performance contexts. Following a first section that questions the role of voice in (theatrical) sonic immersion, the text unfolds as a dialogue between practitioner-scholar Konstantinos Thomaidis and non zero one artist and theatre director Sarah Butcher. The interview lends an attentive ear to the role of voice in the company’s work, from pre-recorded instruction to live audio interaction.
Application Of The Work Breakdown Structure In Determining Cost Buffers In Construction Schedules
Authors: Połoński M. 
Published: October 2015

AbstractThe paper presents methods of determining the location of cost buffers and corresponding contingency costs in the CPM schedule based on its work breakdown structure. Application of correctly located cost buffers with appropriately established reserve costs is justified by the common overrunning of scheduled costs in construction projects. Interpolated cost buffers (CB) as separate tasks have been combined with relevant summary tasks by the start–to–start (SS) relationship, whereas the time of their execution has been dynamically connected with the time of accomplishment of particular summary tasks using the “paste connection” option. Besides cost buffers linked with the group of tasks assigned to summary tasks, a definition of the cost buffer for the entire project (PCB) has been proposed, i.e. as one initial task of the entire project. Contingency costs corresponding to these buffers, depending on the data that the planner has at his disposal, can be determined using different methods, but always depend on the costs of all tasks protected by each buffer. The paper presents an exemplary schedule for a facility and the method of determining locations and cost for buffers CB and PCB, as well as their influence on the course of the curve illustrating the budgeted cost of work scheduled (BCWS). The proposed solution has been adjusted and presented with consideration of the possibilities created by the scheduling software MS Project, though its general assumptions may be implemented with application of other similar specialist tools.
Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids
Authors: Snježana Petrović , Aleksandra Arsić , Jasmina Debeljak-Martačić , Maja Đurendić-Brenesel , Vladimir Pilija , Nataša Milić , Tamara Popović 
Published: October 2015

Abstract
The aim of our study was to stablish the possible alternations in fatty acid composition of brain phospholipids in rats on a standard and high-fat diet supplemented with buckwheat leaf and flower mixture (BLF) and subsequent possible beneficial effects of BLF. Four months old male Wistar rats were randomly divided into five experimental groups fed a standard diet, standard diet supplemented with 5% BLF, high-fat diet, high-fat diet with full-period (13 weeks) of 5% BLF supplementation and high-fat diet with partial-period (7 weeks) of 5% BLF supplementation. Gas-liquid chromatography was performed to analyze the fatty acids in hexane lipid extracts of whole rat brains.
Supplementation with BLF did not induce significant changes in fatty acid composition of whole brain phospholipids in rats fed the standard diet. In rats on high-fat diet concomitant (full-period) BLF supplementation increased eicosapentaenoic acid (20:5n-3, EPA), total n-6 and n-6/n-3 ratio, and decreased the percentage of oleic acid (18:1n-9) and estimated activity of Δ-9 desaturase. When BLF application was postponed (partial-period) in the case of developed hyperlipidemia, a decrease of stearic acid (18:0) accompanied with an increased estimated Δ-9 desaturase activity was observed. Regardless of BLF supplementation all high-fat diet-fed groups showed an elevated percentage of linoleic acid (18:2n-6, LA) and a reduced estimated Δ-6 desaturase activity.
BLF contributes to the maintenance of stable fatty acid composition of brain phospholipids and supports normal brain function in high-fat diet rats, with more positive effects when BLF was applied before hyperlipidemia developed. This could be the mode of buckwheat health beneficial effects on the brain.
Mercury concentration in bivalve molluscs
Authors: Szkoda Józef , Durkalec Maciej , Nawrocka Agnieszka , Michalski Mirosław 
Published: October 2015

Abstract
A total of 85 mussel samples of eight species were examined. Analysis of mercury in the freeze-dried samples was carried out by atomic absorption spectrometry method using direct mercury analyser AMA 254. The analytical procedure for determination of mercury was covered by the quality assurance programme of research and participation in national and international proficiency tests. Concentrations of total mercury in all investigated samples were found to be generally low, in the range of 0.033-0.577 mg/kg of dry weight and of 0.003-0.045 mg/kg of wet weight. The results indicate that obtained levels of mercury in bivalve molluscs are not likely to pose a risk to the health of consumers.
On the concrete hardness of Learning with Errors
Authors: Albrecht Martin R. , Player Rachel , Scott Sam 
Published: October 2015

Abstract
The learning with errors (LWE) problem has become a central building block of modern cryptographic constructions. This work collects and presents hardness results for concrete instances of LWE. In particular, we discuss algorithms proposed in the literature and give the expected resources required to run them. We consider both generic instances of LWE as well as small secret variants. Since for several methods of solving LWE we require a lattice reduction step, we also review lattice reduction algorithms and use a refined model for estimating their running times.
We also give concrete estimates for various families of LWE instances, provide a Sage module for computing these estimates and highlight gaps in the knowledge about algorithms for solving the LWE problem.
The Quality of Life in Pregnant Women Conceiving Through In Vitro Fertilization
Authors: Globevnik Velikonja Vislava , Lozej Tina , Leban Gaja , Verdenik Ivan , Vrtačnik Bokal Eda 
Published: October 2015

AbstractObjectiveThe aim was to determine whether pregnant women conceiving through in vitro fertilization (IVF) differ from those conceiving spontaneously in terms of psychological well-being and the quality of life.MethodsIn a prospective study we included 75 women conceived after IVF and 78 who conceived spontaneously in the same time period (control group). All the women were sent a self-report questionnaire about demographic and reproductive history, health, pregnancy concerns, containing Subjective Quality of Life Scale (QLS), Positive and Negative Affect Schedule (PANAS), the Psychological Well-Being Scale (PWB), Beck Depression Inventory (BDI), and Zung Self-Assessment Anxiety Scale (SAS); obstetric and newborn’s data were obtained from medical records. Response rate was 66.6% in the IVF and 83.3% in control group.ResultsThe mean women’s age was 33.8 years in the IVF, and 32.5 years in the control group (NS). There were no significant differences between groups on the most of the outcome measures assessing psychological status. IVF mothers were just less satisfied in “friend/acquaintances” (P=0.03), a higher percentage had sexual problems prior to conception (P=0.03); the length of hospitalization during pregnancy was longer (P=0.02), and the preterm delivery rate was higher (P=0.01). Withingroup changes over gestation time indicated that IVF women, not controls, showed an increase in positive affect (P=0.04) and purpose in life (P=0.05).ConclusionsIVF women are inclined to social isolation. Despite more medical problems during pregnancy, they reported improved positive emotions and purpose in life as the pregnancy progressed.
Últimas tendencias en la producción científica europea en ciencias sociales, comunicación y humor gráfico (2007-2011)
Authors: Segado Boj Francisco 
Published: October 2015

Esta investigación analiza las tendencias existentes en la producción científica europea en Ciencias Sociales que toma como objeto de estudio el humor gráfico. Para ello se han analizado los datos disponibles en el ISI Web of Knowledgesobre los artículos científicos publicados al respecto en esta base de datos de referencia. Con estos datos se ha analizado esta producción científica por autores, instituciones y países de procedencia, así como por las áreas de interés a la que se adscriben las revistas en las que se han incluido esos artículos. Se ha prestado también especial atención al impacto de cada uno de estos trabajos, medido en el número de citas recibido por cada artículo. De este modo se ha demostrado que la Comunicación muestra un especial interés hacia este objeto de estudio que no se traduce en un número de citas parejo.
Emprendedores y creativos: una propuesta interdisciplinar de innovación docente
Authors: Muñoz de Luna Ángel Bartolomé , Viñarás Abad Mónica , Llorente Barroso Carmen 
Published: October 2015

Uno de los fundamentos de la implantación del EEES es la necesidad de acercar empresa y Universidad, en aras de mejorar la formación del universitario para que su incorporación al mercado laboral sea más eficaz. Partiendo de esta premisa, la Universidad deberá hacer un esfuerzo por invitar a sus aulas a profesionales y facilitar al alumno un contacto directo con la realidad de la empresa. En el sector profesional y la formación que nos ocupa, la Publicidad y Relaciones Públicas, esta necesidad de acercar empresa y Universidad, es de las más acuciantes, por las salidas profesionales que ofrece. Por ello, desde el departamento de Publicidad y Comunicación Institucional de la Universidad CEU San Pablo, se tomó una iniciativa (“Concurso de Emprendedores y Creativos”) que implicaba a diversas asignaturas, con el objetivo de poner en contacto a alumnos con anunciantes, para que trabajaran en una campaña real.Este artículo recoge esta experiencia docente e interdisciplinar, que ofrece a los alumnos una forma de aprendizaje eficaz, ajustándose a las competencias que debe adquirir el alumno en su formación académica. Esta iniciativa, tras su segundo año de vida, se ha consolidado como proyecto de innovación docente dentro del marco del EEES.
Los sistemas multimedia digitales interactivos en los museos
Authors: Mihura López Rocío , Barneche Naya Viviana , Hernández Ibáñez Luis Antonio 
Published: October 2015

Los museos basan su potencial educativo en la posibilidad por parte del visitante de vivir una experiencia de forma directa, ya sea a partir de un objeto u ambiente recreado. Como entidades que dependen directamente de la sociedad y que experimentan a la vez sus avances, han implementado la tecnología multimedia digital en las exposiciones con mayor o menor éxito. Uno de los resultados positivos es su atractivo para todo tipo de público y su potencial para mostrar la complejidad histórica o social de un objeto.
Los medios sociales en situaciones de crisis: del 11-M al 13-M
Authors: Doval Avendaño Mª Montserrat 
Published: October 2015

El día 13 de marzo de 2004 se convocó una manifestación en Madrid ante la sede del Partido Popular en el día de reflexión antes de las elecciones generales y tras los atentados del 11. La convocatoria pasó de las redes sociales a los medios de comunicación y de los medios a la opinión pública, que contempló cómo las movilizaciones se multiplicaban en varias ciudades de España. Este trabajo investiga sobre la posibilidad de que el flujo de comunicación entre medios y grupos sociales se pueda explicar a través de modelos compatibles del Two-step flowy el Agenda-setting.
Innovación y tecnología: necesidad de cambios en los procesos de enseñanza – aprendizaje, inclusión de competencias y compromiso desde la formación docente
Authors: Rodríguez Torres Javier 
Published: October 2015

Coincidimos con Fullan al considerar que una de las principales dificultades para la mejora de las escuelas de occidente no es la ausencia de innovación, más bien la presencia de demasiados proyectos novedosos inconexos, episódicos, fragmentados y adornados de forma superflua. El mayor problema al que se enfrentan las escuelas es la fragmentación (balcanización) y exceso de innovaciones. Los cambios estructurales, de organización, de gestión, de diseño curricular, de condiciones laborales, de tipología de alumnado... que vivimos en los últimos veinte años son, cuando menos, asombrosos y productores de gran INCERTIDUMBRE, se suma, además, la realidad regional, es decir, la propia configuración de nuestro país.Por otro lado, no podemos negar las posibilidades de acceso al saber que proporcionan los artefactos tecnológicos, produciendo un efecto psicológico de engrandecimiento que eleva nuestra autoestima y estimula a desarrollos ilimitados. Ahora bien, sabemos que cuando una actividad realizada con TIC se centra en la máquina y aplicaciones, descontextualizadamente, no genera más que información. La euforia y utilización acrítica de la tecnología como innovación, puede esconder un nuevo mesianismo y encubrir una perversión ideológica: la nivelación ilusoria de la humanidad como consecuencia de la nivelación potencial de un grupo de individuos, de una parcela de sus vidas en el ciberespacio.
El treinta aniversario del 23-F en la web 2.0: la teoría de la espiral del silencio en la “audiencia creativa”
Authors: Martín Jiménez Virginia , Campos Domínguez Eva 
Published: October 2015

En un contexto marcado por el surgimiento de la denominada por Manuel Castells (2010) “audiencia creativa” y “autocomunicación de masa” y tomando en consideración los estudios de audiencias, esta investigación pretende conocer –tal y como han apuntado ya algunos autores como Neuwirth (2007), Hai-long (2001), entre otros– si la teoría de la espiral del silencio puede resultar válida también en los estudios de comunicación en Internet.Para ello, tras la pertinente revisión bibliográfica, esta investigación aborda un estudio concreto basado en el análisis de contenido descriptivo de los comentarios realizados a la noticia más leída y comentada por los usuarios sobre el fallido golpe de estado del 23-F, a raíz de su treinta aniversario, en el portal español de ranking editorial www.meneame.net, así como también los comentarios realizados sobre la propia información original –una entrevista publicada en el diario Público- para tratar de verificar o refutar si, en los estudios de comportamiento de las audiencias en el ciberespacio, puede considerarse como aplicable, o no, la teoría clásica de la alemana Elisabeth Noelle-Neumann.