bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol abuse and discretionary habits in psoriatic patients: impact on IL‐17 and IL‐23 inhibitors response
Authors: Mastorino Luca , Daniele Rebecca , Dapavo Paolo , Frigatti Giada , Ponti Renata , Giunipero di Corteranzo Isotta , Bongiovanni Eleonora , Quaglino Pietro , Ribero Simone 
Published: July 2024

SummaryBackgroundAlcohol abuse is correlated with the onset and worsening of psoriasis, but its effects, as for smoking, on biological therapies are still poorly investigated.Materials and methodsThis study aimed to determine the prevalence of alcohol abuse and other discretionary habits (such as smoking and sedentary lifestyle) in patients with psoriasis treated with topicals, conventional systemic and biologic therapies. The second objective is to investigate the impact of discretionary habits, focusing on alcohol abuse, on the response to biological therapy. To identify alcohol dependence, the CAGE questionnaire was distributed among patients of our clinic.Results305 patients were included with 18% at high risk of alcohol abuse. Clinically, guttate psoriasis and psoriatic arthritis were more common in patients at higher risk of alcohol abuse. Furthermore, patients with an alcohol problem who started biological therapy reported a higher PASI than those who drank less. None of the considered variables seemed to correlate with discontinuation of medication or with lower achievement of the analyzed outcomes (PASI100, PASI90, and PASI≤3). There was a stronger association between alcohol dependence and patients receiving conventional therapy than with patients receiving biologics.ConclusionsThe efficacy of biologicals did not seem to be impacted by alcohol consumption, smoking, or sedentary lifestyle.
Retrospective study of postoperative survival of keratinocyte‐derived skin cancer patients at the end of life
Authors: Ahmadipour Mahya , Kitzwögerer Melitta , Trautinger Franz 
Published: July 2024

SummaryBackground and objectivesBasal and squamous cell carcinoma (BCC, SCC), collectively referred to as keratinocyte‐derived skin cancer (KC), are the most common human cancers worldwide. Surgery is the treatment of choice, but may represent overtreatment in the very elderly. This study aims to address this issue by investigating the life expectancy of patients over 80 years after surgery.Patients and methodsA single‐center, retrospective study was performed to include surgically treated KC patients at the Department of Dermatology and Venereology of the University Hospital in St. Pölten, Austria, between 01.01.2011 and 31.12.2017, who were 80 years or older. Data on individual survival (cut‐off April 30, 2020), date and cause of death were retrieved from the Austrian national demographic database at Statistics Austria (Vienna).Results940 patients (450 female, 490 male, 639 BCCs, 301 SCCs) were included with 307 being alive at the cut‐off date. Median postoperative survival was 57 months (95% CI, 54–63 months).ConclusionsWith a median postoperative survival of almost 5 years, surgery remains a valid treatment option for KC at the end of life. However, 77 of the treated patients died within a year after surgery and preoperative assessment might have helped to avoid overtreatment in some of these cases.
The effect of physical activity on glycaemic control in people with type 1 diabetes mellitus: A systematic literature review and meta‐analysis
Authors: De Cock Diederik , Schreurs Lucas , Steenackers Nele , Pazmino Sofia , Cools Wilfried , Eykerman Lauren , Thiels Hannah , Mathieu Chantal , Van der Schueren Bart 
Published: July 2024

AbstractAimsType 1 diabetes mellitus (T1DM) is characterised by insulin deficiency. Due to perceived physical activity (PA)‐related hypoglycaemia, a minority of people with T1DM exercise regularly. However, the relationship between T1DM and PA remains poorly understood. Our aim was to summarise the existing literature on the effects of PA on short‐term glucose control (glycated haemoglobin or time in range) in people with T1DM.MethodsWe searched seven electronic databases (PubMed, Embase, Cochrane library, Cinahl, SPORTDiscus, PEDro and Web Of Science) and two sources of the grey literature (ClinicalTrials.gov and ICTRP). All reviews were screened via title/abstract and full text by two independent reviewers (LE and HT), conflicts were solved by a third independent reviewer (DDC). We excluded animal studies, case reports, non‐English articles, qualitative studies, conference abstracts and articles without full‐text access. A meta‐analysis using random effects model was performed to study the effect of PA on haemoglobin A1c (HbA1c) levels in people with T1DM.ResultsWe obtained 19,201 unique references across nine different electronic databases. After screening and snowballing, 68 articles were found investigating the effect of PA on glycaemic control in people with T1DM. Overall, HbA1c levels in the PA group (mean difference = 0.29% (0.20%–0.39%)), were lower compared with the control group.ConclusionAn overall small beneficial effect of PA on glycaemic control in people with T1DM was found. Caution is advised when interpreting the results of this meta‐analysis, given variations in study type, duration, frequency and intensity of physical activity across included studies.
Human brain dynamics dissociate early perceptual and late motor‐related stages of affordance processing
Authors: Wang Sheng , Djebbara Zakaria , Sanches de Oliveira Guilherme , Gramann Klaus 
Published: July 2024

AbstractAffordances, the opportunities for action offered by the environment to an agent, are vital for meaningful behaviour and exist in every interaction with the environment. There is an ongoing debate in the field about whether the perception of affordances is an automated process. Some studies suggest that affordance perception is an automated process that is independent from the visual context and bodily interaction with the environment, whereas others argue that it is modulated by the visual and motor context in which affordances are perceived. The present paper aims to resolve this debate by examining affordance automaticity from the perspective of sensorimotor time windows. To investigate the impact of different forms of bodily interactions with an environment, that is, the movement context (physical vs. joystick movement), we replicated a previous study on affordance perception in which participants actively moved through differently wide doors in an immersive 3D virtual environment. In the present study, we displayed the same environment on a 2D screen with participants moving through doors of different widths using the keys on a standard keyboard. We compared components of the event‐related potential (ERP) from the continuously recorded electroencephalogram (EEG) that were previously reported to be related to affordance perception of architectural transitions (passable and impassable doors). Comparing early sensory and later motor‐related ERPs, our study replicated ERPs reflecting early affordance perception but found differences in later motor‐related components. These results indicate a shift from automated perception of affordances during early sensorimotor time windows to movement context dependence of affordance perception at later stages, suggesting that affordance perception is a dynamic and flexible process that changes over sensorimotor stages.
First report of Toumeyella parvicornis (Cockerell) (Hemiptera: Coccidae) in Albania and its potential spread in the coastal area of the Balkans
Authors: Di Sora Nicolò , Contarini Mario , Rossini Luca , Turco Silvia , Brugneti Federico , Metaliaj Ramiz , Vejsiu Ina , Peri Leonidha , Speranza Stefano 
Published: July 2024

AbstractDuring a survey carried out in October 2023, a severe infestation caused by the pine tortoise scale, Toumeyella parvicornis (Cockerell), was observed for the first time in Albania. To confirm the identity of the species, specimens were collected and characterized using morphological and molecular methods. T. parvicornis is native to North America, and Albania is the third European country where the pest has been reported, after Italy (2014) and France (2021). In these countries, this pest is causing severe damage to stone pines through its feeding activity, causing dieback and, in cases of severe infestation, the death of the trees. These observations highlight the potential harmfulness of this species and the need for effective management action on a large scale in the Balkan area. Therefore, further actions are suggested that may be beneficial for early detection and containment.
First record of Leucoptera malifoliella (O. Costa, 1836) (Lepidoptera: Lyonetiidae) in Tunisia
Authors: Soltani Rasmi , Rahmouni Hedi 
Published: July 2024

AbstractThe leaf blister moth, Leucoptera malifoliella is an invasive pest of apple and other Rosaceae species. It causes significant damage to apple leaves, threatening the production quality and the overall health of the tree. In this paper, we report the first record of L. malifoliella in Tunisia and give details of its distribution in apple orchards of central west Tunisia (Kasserine governorate). After signs of the pest were observed, cocoons were collected from the field and reared until adult eclosion. Identification of the species was based on observations of external morphology in the laboratory in addition to the field diagnosis based on larval damage on leaves. Leucoptera malifoliella was collected firstly in Foussana delegation, then in Sbeitla, Sbiba, Djedliane, Kasserine and Feriana delegations, showing that it is widely spread in the Kasserine governorate. This leaf miner was clearly identified as one of the most abundant pests in some localities. This paper describing the first record of L. malifoliella in central west Tunisia aims to raise awareness on the pest and encourage the collaboration between apple producers, researchers and extension services in the region to establish a programme of monitoring and managing the pest.
Leveraging the genetic diversity of trout in the rivers of the British Isles and northern France to understand the movements of sea trout (Salmo trutta L.) around the English Channel
Authors: King R. Andrew , Ellis Charlie D. , Bekkevold Dorte , Ensing Dennis , Lecointre Thomas , Osmond Daniel R. , Piper Adam , Roberts Dylan E. , Launey Sophie , Stevens Jamie R. 
Published: July 2024

AbstractPopulations of anadromous brown trout, also known as sea trout, have suffered recent marked declines in abundance due to multiple factors, including climate change and human activities. While much is known about their freshwater phase, less is known about the species' marine feeding migrations. This situation is hindering the effective management and conservation of anadromous trout in the marine environment. Using a panel of 95 single nucleotide polymorphism markers we developed a genetic baseline, which demonstrated strong regional structuring of genetic diversity in trout populations around the English Channel and adjacent waters. Extensive baseline testing showed this structuring allowed high‐confidence assignment of known‐origin individuals to region of origin. This study presents new data on the movements of anadromous trout in the English Channel and southern North Sea. Assignment of anadromous trout sampled from 12 marine and estuarine localities highlighted contrasting results for these areas. The majority of these fisheries are composed predominately of stocks local to the sampling location. However, there were multiple cases of long‐distance movements of anadromous trout, with several individuals originating from rivers in northeast England being caught in the English Channel and southern North Sea, in some cases more than 1000 km from their natal region. These results have implications for the management of sea trout in inshore waters around the English Channel and southern North Sea.
Metabolomic profiling and accurate diagnosis of basal cell carcinoma by MALDI imaging and machine learning
Authors: Brorsen Lauritz F. , McKenzie James S. , Pinto Fernanda E. , Glud Martin , Hansen Harald S. , Haedersdal Merete , Takats Zoltan , Janfelt Christian , Lerche Catharina M. 
Published: July 2024

AbstractBasal cell carcinoma (BCC), the most common keratinocyte cancer, presents a substantial public health challenge due to its high prevalence. Traditional diagnostic methods, which rely on visual examination and histopathological analysis, do not include metabolomic data. This exploratory study aims to molecularly characterize BCC and diagnose tumour tissue by applying matrix‐assisted laser desorption ionization mass spectrometry imaging (MALDI‐MSI) and machine learning (ML). BCC tumour development was induced in a mouse model and tissue sections containing BCC (n = 12) were analysed. The study design involved three phases: (i) Model training, (ii) Model validation and (iii) Metabolomic analysis. The ML algorithm was trained on MS data extracted and labelled in accordance with histopathology. An overall classification accuracy of 99.0% was reached for the labelled data. Classification of unlabelled tissue areas aligned with the evaluation of a certified Mohs surgeon for 99.9% of the total tissue area, underscoring the model's high sensitivity and specificity in identifying BCC. Tentative metabolite identifications were assigned to 189 signals of importance for the recognition of BCC, each indicating a potential tumour marker of diagnostic value. These findings demonstrate the potential for MALDI‐MSI coupled with ML to characterize the metabolomic profile of BCC and to diagnose tumour tissue with high sensitivity and specificity. Further studies are needed to explore the potential of implementing integrated MS and automated analyses in the clinical setting.
Disentangling the drivers of urban bird diversity in the non‐breeding season: A general synthesis
Authors: Moreno‐Contreras Israel , Jokimäki Jukka , Kaisanlahti‐Jokimäki Marja‐Liisa , Leveau Lucas M. , Suhonen Jukka , Tobias Joseph A. , Tryjanowski Piotr 
Published: July 2024

AbstractCurrent knowledge about the impacts of urbanisation on bird assemblages is based on evidence from studies partly or wholly undertaken in the breeding season. In comparison, the non‐breeding season remains little studied, despite the fact that winter conditions at higher latitudes are changing more rapidly than other seasons. During the non‐breeding season, cities may attract or retain bird species because they offer milder conditions or better feeding opportunities than surrounding habitats. However, the range of climatic, ecological and anthropogenic mechanisms shaping different facets of urban bird diversity in the non‐breeding season are poorly understood. We explored these mechanisms using structural equation modelling to assess how urbanisation affects the taxonomic, phylogenetic and functional diversity of avian assemblages sampled worldwide in the non‐breeding season. We found that minimum temperature, elevation, urban area and city age played a critical role in determining taxonomic diversity while a range of factors—including productivity, precipitation, elevation, distance to coasts and rivers, socio‐economic (as a proxy of human facilitation) and road density—each contributed to patterns of phylogenetic and functional diversity. The structure and function of urban bird assemblages appear to be predominantly shaped by temperature, productivity and city age, with effects of these factors differing across seasons. Our results underline the importance of considering multiple hypotheses, including seasonal effects, when evaluating the impacts of urbanisation on biodiversity.
Quantifying co‐extinctions and ecosystem service vulnerability in coastal ecosystems experiencing climate warming
Authors: Wilkes Lexi N. , Barner Allison K. , Keyes Aislyn A. , Morton Dana , Byrnes Jarrett E. K. , Dee Laura E. 
Published: July 2024

AbstractClimate change is negatively impacting ecosystems and their contributions to human well‐being, known as ecosystem services. Previous research has mainly focused on the direct effects of climate change on species and ecosystem services, leaving a gap in understanding the indirect impacts resulting from changes in species interactions within complex ecosystems. This knowledge gap is significant because the loss of a species in a food web can lead to additional species losses or “co‐extinctions,” particularly when the species most impacted by climate change are also the species that play critical roles in food web persistence or provide ecosystem services. Here, we present a framework to investigate the relationships among species vulnerability to climate change, their roles within the food web, their contributions to ecosystem services, and the overall persistence of these systems and services in the face of climate‐induced species losses. To do this, we assess the robustness of food webs and their associated ecosystem services to climate‐driven species extinctions in eight empirical rocky intertidal food webs. Across food webs, we find that highly connected species are not the most vulnerable to climate change. However, we find species that directly provide ecosystem services are more vulnerable to climate change and more connected than species that do not directly provide services, which results in ecosystem service provision collapsing before food webs. Overall, we find that food webs are more robust to climate change than the ecosystem services they provide and show that combining species roles in food webs and services with their vulnerability to climate change offer predictions about the impacts of co‐extinctions for future food web and ecosystem service persistence. However, these conclusions are limited by data availability and quality, underscoring the need for more comprehensive data collection on linking species roles in interaction networks and their vulnerabilities to climate change.
Aristotelian versus Platonic and Machiavellian interpretations of phronesis: A critical reflection on leadership and management education
Authors: Girado‐Sierra Jesús David , Gallego‐Ortiz María Camila , Thoene Ulf 
Published: July 2024

AbstractGiven the high incidence of corporate scandals, we are faced with reconsidering management theory, principles and education. The purpose of this paper is threefold. First, we seek to show that it is necessary and possible to analyse current managerial and directive action in the light of Aristotle's ethical thought, specifically concerning phronesis (practical wisdom). The second aim is to highlight that the Platonic interpretation of phronesis as a matter of contemplative life contributes to an inadequate leadership style and ethical apathy. Furthermore, we claim that the Machiavellian interpretation of phronesis contributes to leadership based on manipulation and exclusion of morality in management. The third and final objective is to respond to these two interpretations by reviewing Aristotle's exceptional teachings on the relevance of phronesis as a special kind of wisdom in which good judgment, discernment and an adequate understanding of events for decision‐making converge. An essential claim of this paper is that Aristotle and his notion of phronesis, rather than Plato's or Machiavelli's, ought to inform contemporary debates in management scholarship and education. Aristotle's philosophical insights into practice, wisdom and more comprehensive ethics are highly relevant for public discourse in our contemporary societal context, especially for management education. Integrating phronesis into management and leadership education involves using case studies and experiential learning to teach practical wisdom and sound judgment.
Sheffield One‐Stop Service: A potential model to improve the screening uptake of diabetic peripheral neuropathy and other microvascular complications of diabetes
Authors: Sloan Gordon , Dela Pena Pepito , Andag‐Silva Aimee , Cunanan Elaine , Jimeno Cecilia , Robles Jeremy Jones , Tesfaye Solomon 
Published: July 2024

ABSTRACTThe world is experiencing an enormous rise in the prevalence of diabetes, which is associated with massive healthcare costs that threaten to overwhelm many healthcare systems. Most of the diabetes expenditure is attributed to the management of chronic diabetes complications, including diabetic peripheral neuropathy (DPN)/diabetic foot complications, chronic kidney disease, sight‐threatening retinopathy and cardiovascular diseases. Of these complications, the most overlooked is DPN. Most consultations around the world do not even involve taking off shoes and socks to carry out a foot examination, and even when carried out, the peripheral neurological examination using the 10‐g monofilament diagnoses DPN when it is already at an advanced stage. Thus, all too often diabetes complications are diagnosed late, resulting in devastating outcomes, particularly in low‐ to middle‐income countries. There is, therefore, an urgent need to instigate new strategies to improve microvascular screening uptake using a holistic protocol for annual diabetes health checks outside the busy diabetes clinic. One such approach, the Sheffield One‐Stop Microvascular Screening Service, which involves modern point of care devices to diagnose DPN, has been shown to be feasible and effective, resulting in high uptake and early management of diabetes complications. This article outlines the advantages of this One‐Stop Microvascular Screening Service and a plan to trial an adapted version of this service to a resource‐limited country, the Philippines. If successful, this model has the potential for implementation in other countries around the world.
Double marginalization in the pricing of complements: The case of US freight railroads
Authors: Alexandrov Alexei , Pittman Russell , Ukhaneva Olga 
Published: July 2024

AbstractMonopolists selling complementary products charge a higher price in a static equilibrium than a single (multiproduct) monopolist would, reducing both the industry profits and consumer surplus. Firms could instead reach a Pareto improvement by lowering prices to the single‐monopolist level. We analyze pricing data of railroad coal shipping in the United States. We compare a coal producer that needs to ship from A to C, with the route passing through B, in two cases: (1) the same railroad owning AB and BC and (2) different railroads owning AB and BC. We do not find that the price in case (2) is higher than the price in case (1), suggesting that the complementary monopolist pricing inefficiency is absent in this market. Our findings are robust to propensity score blocking, causal machine learning algorithms, and difference‐in‐differences analysis. Our results have implications for vertical mergers, tragedy of the anticommons, mergers of firms selling complements, elimination of double marginalization, and royalty stacking and patent thickets.