bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Understanding of Thermally Grown Oxide Morphology Effect on the Thermal Barrier Coatings Failure Under Free Edges
Authors: Qiao Da , Zeng Wu 
Published: July 2024

Abstract
The growth stresses induced by the thermally grown oxide (TGO) will be amplified at the free-edge site, making the free-edge site a weak part of the thermal barrier coatings (TBCs). In this study, the TBCs failure behavior is investigated based on different TGO morphologies under free edges. The thermomechanical model is established by creating straight lines and simplified sinusoidal curves, respectively. Dynamic TGO growth is realized by the secondary development of the subroutine. The cohesive element is inserted at the top coat (TC)/TGO interface to simulate the delamination. The stress evolution near different TGO morphologies under the influence of the free edge is examined. In addition, the interfacial cracking behavior near the free edge is also explored. The results show that the appearance of the free edge will deteriorate the stress condition in the nearby area, change the preferred cracking area, and induce the earlier failure behavior. The straight line morphology has the most “friendly” stress distribution. The sinusoidal curves have peaks and valleys, and different areas of the TGO shape are different under the influence of the free edge, but all of them have the effect of stress “convergence.” These results can provide significant guidance to develop the next-generation advanced TBCs.
Deployment Dynamics and Control of a Hub-Spoke Tethered Satellite Formation Using Combined Arbitrary Lagrange-Euler and Referenced Nodal Coordinate Formulation
Authors: Yu Wang , Wei Fan , Hui Ren 
Published: July 2024

Abstract
A novel modeling framework combining arbitrary Lagrange-Euler and referenced nodal coordinate formulation (ALE-RNCF) is proposed for deployment dynamics and control of a hub-spoke tethered satellite formation. The ALE-RNCF approach allows for an accurate analysis of the intricate coupling effect between the orbit, attitude, and deployment dynamics, and its strengths lie in overcoming the accuracy loss and low-efficiency issues when dealing with spatial and temporal multiscale problems. Specifically, the orbital and attitude motions are separated with vibrations of the variable-length ALE tethers through the RNCF, which is the main distinguishing feature over the widely-used absolute nodal coordinate formulation. To achieve stable deployment, the control torque is added to the central satellite by employing the proportional-differential algorithm, where the maximum tension of tethers or the spinning angular velocity is selected as the control object. Various cases with different deployment velocities, target tensions, and orbital heights are simulated and corresponding effects on the deployment performance are analyzed. The proposed ALE-RNCF approach provides a comprehensive understanding of the orbit-attitude-structure coupled behavior during the deployment of the hub-spoke tethered satellite formation and contributes to the development of effective control strategies.
LAMN port-site metastasis after laparoscopic oophorectomy for a presumed ovarian tumour treated with CRS and HIPEC
Authors: Abramov Roi , Ashkenazi Itamar , Hoffman Aviad L 
Published: July 2024

Low-grade appendiceal mucinous neoplasm (LAMN) may culminate as a mucin-secreting disease known as pseudomyxoma peritonei (PMP). Once the diagnosis of LAMN and PMP is made, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS and HIPEC) are indicated.Herein, we present a female patient in her 50s who was diagnosed with an ovarian mass for which she underwent laparoscopic oophorectomy. As the pathology of the ovary showed a tumour of gastrointestinal origin, she then underwent CRS and HIPEC with a final pathology of LAMN. Six weeks later, a mucinous lesion confined to the abdominal wall was detected on a postoperative CT. Suspected for port-site metastasis at the laparoscopic trocar site, we treated this lesion using the same principles of treatment as the intra-abdominal disease. The abdominal wall mass was surgically resected, and the cavity created was irrigated with mitomycin C. On 30 months of follow-up, the patient had no evidence of disease.
Williams–Beuren syndrome diagnosis in an infant with atypical chromosome 7 microdeletion
Authors: Olowu Adekunle A 
Published: July 2024

This patient is an infant with Williams–Beuren syndrome (WBS) who was diagnosed at 2 months of age. He was born by caesarean section with a low birth weight (LBW) of 2.1 kg and was small for gestational age. His para 1+1 (1 alive) mother in her mid-30s had intrauterine growth restriction during pregnancy. On examination at birth, he appeared phenotypically normal, but at 2 weeks old, he had subtle phenotypic features of WBS of fused filtrum, ulnar deviation of fingers and wide anterior fontanelle, a systolic murmur and mild gaseous distension of the abdomen.All neonatal reflexes were normal. The author saw this patient at 6 months of age at the well-baby clinic for his 6-month vaccinations during which examination revealed periorbital fullness. Investigations including chromosomal microarray analysis confirmed the diagnosis of WBS. Laboratory tests were essentially normal except for raised creatinine, chloride and liver aspartate transaminase and viral serology that showed reactive cytomegalovirus antibody IgG, rubella antibody IgG, toxoplasma IgG and positive herpes simplex virus type 1 IgG. Echocardiography revealed mild pulmonary artery stenosis. ECG revealed right ventricular hypertrophy. Abdominal ultrasonography was normal and so was cranial sonography. This is a unique case of early diagnosis of WBS in an infant with atypical chromosome 7 deletion in Qatar, Middle East. The patient is undergoing further multidisciplinary follow-up.
Switching from Dose-Intensified intravenous to SubCutaneoUS infliximab in Inflammatory Bowel Disease (DISCUS-IBD): protocol for a multicentre randomised controlled trial
Authors: Little Robert D , McKenzie Jo , Srinivasan Ashish , Hilley Patrick , Gilmore Robert B , Chee Desmond , Sandhu Manjeet , Saitta Daniel , Chow Elizabeth , Thin Lena , Walker Gareth J , Moore Gregory T , Lynch Kate , Andrews Jane , An Yoon K , Bryant Robert V , Connor Susan J , Garg Mayur , Wright Emily K , Hold Georgina , Segal Jonathan P , Boussioutas Alex , De Cruz Peter , Ward Mark G , Sparrow Miles P 
Published: July 2024

IntroductionA substantial proportion of patients with inflammatory bowel disease (IBD) on intravenous infliximab require dose intensification. Accessing additional intravenous infliximab is labour-intensive and expensive, depending on insurance and pharmaceutical reimbursement. Observational data suggest that subcutaneous infliximab may offer a convenient and safe alternative to maintain disease remission in patients requiring dose-intensified infliximab. A prospective, controlled trial is required to confirm that subcutaneous infliximab is as effective as dose-intensified intravenous infliximab, to identify predictors of disease flare and to establish the role of subcutaneous infliximab therapeutic drug monitoring.Methods and analysisThe DISCUS-IBD trial is an investigator-initiated, prospective, multicentre, randomised, open-label non-inferiority study comparing the rate of disease flares in participants randomised to continue dose-intensified intravenous infliximab to those switched to subcutaneous infliximab after 48 weeks. Participants are adult patients with IBD in sustained corticosteroid-free remission on any regimen of dose-intensified infliximab up to a maximum of 10 mg/kg 4-weekly intravenously. Participants allocated to intravenous infliximab will continue infliximab at the same dose-intensified regimen they were receiving at study enrolment. Subcutaneous infliximab dosing will be stratified by prior intravenous infliximab dosing. Clinical (Harvey-Bradshaw Index, partial Mayo score), biochemical (C reactive protein, faecal calprotectin), pharmacokinetic (drug-level±antidrug antibodies) and qualitative data are collected 12-weekly until study conclusion at week 48. 13 sites across Australia will participate in recruitment to reach a calculated sample size of 120 participants.Ethics and disseminationMultisite ethics approval was obtained from the Health District Human Research Ethics Committee (HREC) at The Alfred Hospital under a National Mutual Acceptance (NMA) agreement (HREC/90559/Alfred-2022; Local Reference: Project 618/22, version 1.6, 2 March 2023). Findings will be reported at national and international gastroenterology meetings and published in peer-reviewed journals. DISCUS-IBD was prospectively registered with the Australian and New Zealand Clinical Trials Registry (ANZCTR) prior to commencing recruitment.Trial registration numberACTRN12622001458729.
Effects of hydromorphone-based patient-controlled intravenous analgesia on postoperative hypoxaemia: a randomised controlled non-inferiority clinical trial
Authors: Ma Yumei , Feng Xiangying , Yan Nong , Deng Zhuomin , Luo Jialin , Lin Jingjing , Zheng Ziyu , Mu Xiaoxiao , Yang Xuan , Du Jiejuan , Meng Yang , Dong Hailong , Nie Huang 
Published: July 2024

ObjectiveThis study aimed to compare the effects of patient-controlled intravenous analgesia (PCIA) with and without low-basal infusion on postoperative hypoxaemia.DesignA randomised parallel-group non-inferiority trial.SettingThe trial was conducted at a grade-A tertiary hospital from December 2021 to August 2022.Participants160 adults undergoing gastrointestinal tumour surgery and receiving postoperative PCIA.InterventionsParticipants randomly received a low-basal (0.1 mg/hour of hydromorphone) or no-basal infusion PCIA for postoperative 48 hours.Primary and secondary outcome measuresPrimary outcome was area under curve (AUC) per hour for hypoxaemia, defined as pulse oxygen saturation (SpO2) <95%. Secondary outcomes included: AUC per hour at SpO2<90% and <85%, hydromorphone consumption, ambulation time and analgesic outcomes up to 48 hours after surgery.ResultsAmong 160 randomised patients, 159 completed the trial. An intention-to-treat analysis showed that AUC per hour (SpO2<95%) was greater in the low-basal infusion group compared with the no-basal infusion group, with a median difference of 0.097 (95% CI 0.001 to 0.245). Non-inferiority (margin: ratio of means (ROM) of 1.25) was not confirmed since the ROM between the two groups was 2.146 (95% CI 2.138 to 2.155). Hydromorphone consumption was higher in the low-basal group than in the no-basal group (median: 5.2 mg versus 1.6 mg, p<0.001). Meanwhile, there were no differences in the AUC values at the other two hypoxaemia thresholds, in ambulation time, or pain scores between the groups.ConclusionsAmong the patients receiving hydromorphone PCIA after gastrointestinal tumour resection, low-basal infusion was inferior to no-basal infusion PCIA for postoperative hypoxaemia at SpO2<95% up to 48 hours after surgery.Trial registration numberChiCTR2100054317.
Li–Yorke Chaos in Linear Systems with Weak Topology on Hilbert Spaces
Authors: Yang Qigui , Zhu Pengxian 
Published: July 2024

This paper investigates the Li–Yorke chaos in linear systems with weak topology on Hilbert spaces. A weak topology induced by bounded linear functionals is first constructed. Under this weak topology, it is shown that the weak Li–Yorke chaos can be equivalently measured by an irregular or a semi-irregular vector, which are utilized to establish criteria for the weak Li–Yorke chaos of diagonalizable operators, Jordan blocks, and upper triangular operators. In particular, for a linear operator that can be decomposed into a direct sum of finite-dimensional Jordan blocks, it is Li–Yorke chaotic in weak topology if its point spectrum contains a pair of real opposite eigenvalues with absolute values not less than 1, or a pair of complex conjugate eigenvalues with moduli not less than 1. Interestingly, as a specific example of upper triangular operator, the existence of Li–Yorke chaos in weak topology can be derived for a class of linear operators expressed as the direct sum of finite-dimensional Jordan blocks and a strongly irreducible operator.
Periodic Orbit Dividing Surfaces in a Quartic Hamiltonian System with Three Degrees of Freedom – II
Authors: Montoya Francisco Gonzalez , Katsanikas Matthaios , Wiggins Stephen 
Published: July 2024

In prior studies [ Katsanikas & Wiggins , 2021a , 2021b , 2023a , 2023b ], we introduced two methodologies for constructing Periodic Orbit Dividing Surfaces (PODS) tailored specifically for Hamiltonian systems with three or more degrees of freedom. These approaches, as described in the aforementioned papers, were applied to a quadratic Hamiltonian system in its normal form with three degrees of freedom. Within this framework, we provide a more intricate geometric characterization of this entity within the family of 4D toratopes which elucidates the structure of the dividing surfaces discussed in these works. Our analysis affirmed the nature of this construction as a dividing surface with the property of no-recrossing. These insights were derived from analytical findings tailored to the Hamiltonian system discussed in these publications. In this series of papers, we extend our previous findings to quartic Hamiltonian systems with three degrees of freedom. We establish the no-recrossing property of the PODS for this class of Hamiltonian systems and explore their structural aspects. Additionally, we undertake the computation and examination of the PODS in a coupled scenario of quartic Hamiltonian systems with three degrees of freedom. In the initial paper [ Gonzalez Montoya et al. , 2024 ], we employed the first methodology for constructing PODS, while in this paper, we utilize the second methodology for the same purpose.
Plain Chest Film Versus Computed Tomography of the Chest as the Initial Imaging Modality for Blunt Thoracic Injury
Authors: L’Huillier Joseph C. , Carroll Hannah L. , Zhao Jane Y. , Jalal Kabir , Yu Jihnhee , Guo Weidun A. 
Published: July 2024

Background While chest X-ray (CXR) is an efficient tool for expeditious detection of life-threatening injury, chest computed tomography (CCT) is more sensitive albeit with added time, cost, and radiation. Thus far, there is limited evidence and lack of consensus on the best imaging practices. We sought to determine the association between imaging modality and outcomes in isolated blunt thoracic trauma. Methods The 2017-2020 TQIP database was queried for adult patients who sustained isolated blunt chest trauma and underwent chest imaging within 24 hours of admission. Patients who underwent CCT were 2:1 propensity-score-matched to those who underwent CXR. The primary outcome was mortality, and the secondary outcomes were hospital and ICU length of stay (LOS), ICU admission, need for and days requiring mechanical ventilation, complications, and discharge location. Results Propensity score matching yielded 17 716 patients with CCT and 8861 with CXR. While bivariate analysis showed lower 24-hr (CCT .2% vs CXR .4%, P = .0015) and in-hospital mortality (CCT 1.2% vs CXR 1.5%, P = .0454) in the CCT group, there was no difference in survival probability between groups ( P = .1045). A higher percentage of CCT patients were admitted to the ICU (CCT 26.9% vs CXR 21.9%, P < .0001) and discharged to rehab (CCT .8% vs CXR .5%, P = .0178). Discussion CT offers no survival benefit over CXR in isolated blunt thoracic trauma. While CCT should be considered if clinically unclear, CXR likely suffices as an initial screening tool. These findings facilitate optimal resource allocation in constrained environments.
Safety Study of Percutaneous Gastroscopic Gastrostomy in Patients After Ventriculoperitoneal Shunt
Authors: Wang Dexian , Peng Run , Huang Yebin , Zhou Jun , Long Zhihua , Wang Jianjun , Zhang Dejian 
Published: July 2024

Objective To evaluate the safety study of percutaneous gastroscopic gastrostomy in patients after ventriculoperitoneal shunt. Methods We conducted a retrospective analysis of neurosurgical patients who underwent VPS and PEG at our hospital between January 2012 and November 2023. Patients were divided into 2 groups: VPS group and VPS followed by PEG gruop. Patients received routine antibiotic prophylaxis before the procedure, continued for 48 hours. Follow-up included monitoring immediate complications, particularly wound infection, intracranial infection, neurologic status deterioration, and shunt dysfunction. Routine follow-up visits were conducted post-discharge. Results In the VPS group (n = 778), the incidence of intracranial infection was 3.08%. Among patients with PEG after VPS, the time interval between procedures ranged from 13 to 685 days. The mean follow-up period was 22 (1-77) months, with no deaths or further complications. Conclusion Performing PEG more than 13 days after VPS does not significantly increase the risk of intracranial infections or PEG-associated infections, making it a relatively safe procedure.
A case report of primary Kaposiform hemangioendothelioma of the humerus
Authors: Wang Ye , He Zhenqi , Hao Hua 
Published: July 2024

To examine the clinicopathological and immunohistochemical features of Kaposiform hemangioendothelioma (KHE) and discuss its differential diagnosis and prognosis. A patient with KHE was examined; the patient’s clinical and histopathological features were observed, and the expression levels of CD31, CD34, ERG, D2-40, SMA, GLUT-1, and LANA-1 were assessed. The patient was a four-year-old child with primary KHE of the humerus. She was admitted to the hospital because of pain in the right elbow joint and limited movement for more than 2 years. Imaging revealed Langerhans cell histiocytosis. The child was not diagnosed with Kasabach-Merritt phenomenon (KMP). The tumor consists of multiple hemangiomatous nodules with infiltrative growth separated by fibrous connective tissue. The proliferating hemangiomatoid nodules consisted of crisscrossing short spindle-shaped cell bundles and erythrocyte-containing lacunar or crescentic vessels. Immunohistochemical staining showed that the tumor cells diffusely expressed CD31, CD34, ERG, and other vascular endothelium-derived markers; further, the tumor cells expressed neither GLUT-1 nor LANA-1. The patient’s general condition improved after surgical resection. There was no tumor recurrence after more than 8 months of follow-up. Primary KHE of the humerus is a rare vasculogenic tumor. It presents with morphological features that require an accurate differential diagnosis.
Research on the traction characteristic evaluation of urban rail vehicles based on entropy weight TOPSIS
Authors: Zhu Aihua , Long Dongping , Du Cong , Yang Jianwei , Zhang Fan 
Published: July 2024

This paper aims to investigate the influence of different speed at the end of the constant power section of the traction characteristic curve (TCC) on the vehicle dynamic performance and evaluate the TCC. A dynamics co-simulation model is developed in SIMPACK and MATLAB for dynamic analysis of the urban rail vehicle (URV) under different traction characteristics. Then it is used to investigate how acceleration distance and vehicle dynamic performance varies with the speed at the end of the constant power section of the TCC under different starting torques. Moreover, the entropy weight TOPSIS method which is widely used to solve the multi-objective decision-making problem is chosen to evaluate the traction characteristics based on various dynamic performance indexes over 25 test sections and acceleration distance. The results show that under traction conditions, the starting torque has effects on the lateral and vertical accelerations of car body, lateral and vertical wheel-rail contact forces, derailment coefficient and wheel unloading factor. The higher the torque, the greater the value of each index, that means the poorer the vehicle ride characteristics and running safety. For a given starting torque, the dynamic performance indexes increase with the increase of the speed at the end of the constant power section from 50 km/h to 80 km/h during the vehicle speed-up process. The maximum growth rate of the lateral and vertical accelerations of car body, lateral and vertical wheel-rail contact forces are 17%, 8%, 8% and 2%, respectively, when the speed at the end of the constant power section increases from 50 km/h to 80 km/h. Last, the comprehensive evaluation of traction characteristics using entropy-weight TOPSIS method reveals when the starting torque is 800 [Formula: see text], 1000 [Formula: see text], 1200 [Formula: see text] and 1400 [Formula: see text], the corresponding optimal speed at the end of the constant power section is 80 km/h, 80 km/h, 70 km/h and 50 km/h, respectively. The result of the study can provide theoretical support for traction characteristic design and traction control for URVs.
Association between CD4 lymphocyte count and the incidence of comorbidities in Human immunodeficiency virus positive patients with virological suppression after antiretroviral treatment
Authors: Galeano Adriana C , Rincón-Rodríguez CJ , Gil Fabián , Valderrama-Beltrán S 
Published: July 2024

Background The incidence of comorbidities is higher in HIV-positive patients than in the general population due to factors, such as HIV-related chronic inflammation. There is no consensus on whether a low CD4 lymphocyte count after virological suppression at long-term follow-up increases the risk of comorbidities. This study evaluates the association between CD4 lymphocyte count and the incidence of comorbidities during the first 5 years of virological suppression after highly active antiretroviral treatment. Methods We conducted a cohort study of HIV-positive adults who achieved virological suppression in an HIV program between 2002 and 2016 in Colombia. A generalized equation estimation model was used to estimate the association between CD4 lymphocyte count and the incidence of comorbidities. Results A follow-up period of at least 1 year was completed in 921 HIV-positive patients with virological suppression. We found 71 comorbidities during a maximum of 5 years of follow-up; 41 (59%) were AIDS-defining comorbidities and 19 (46%) of them occurred during the first semester. Thirty cases of non-AIDS- defining comorbidities were diagnosed. We did not find any association between CD4 lymphocyte count and the incidence of comorbidities (OR 0.92, CI 95% 0.45 -1.91 for CD4 201-499 cells/µL vs CD4 ≤200 cells/µL, and OR 0.55, 95% CI 0.21-1.44 for CD4 ≥500 cells/µL vs CD4 ≤200 cells/µL). Conclusion No association was found between CD4 lymphocyte count and the incidence of AIDS-defining or non-AIDS-defining comorbidities in patients with virological suppression. Further studies are needed to assess the risk of comorbidities in this population to design interventions aimed at improving their prognosis.