bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmaco-Therapeutic Factors Influencing the Quality of Life in Patients on Anti-Glaucoma Medications for the Treatment of Primary Open-angle Glaucoma: A Cross-Sectional Study
Authors: Dayanand Anushree , Muraraiah Sushma , Naik Yogita U. , Khayoom Nishat S. 
Published: July 2024

Abstract

Purpose:
Vision significantly affects a person’s quality of life (QOL). This study aims to determine the pharmaco-therapeutic factors influencing it among patients on anti-glaucoma medications.

Materials and Methods:
A total of 100 patients diagnosed with primary open-angle glaucoma (POAG) on medications for six weeks were included in this cross-sectional study. QOL was assessed using a pre-validated Glaucoma Quality of Life-15 (GQOL-15) Questionnaire. Adverse drug reactions (ADRs) to the anti-glaucoma medications were determined using the pre-validated Comparison of Ophthalmic Medications for Tolerability (COMTOL) checklist. The Chi-square test, Fisher’s exact test and multiple logistic regression analysis were performed to test the statistical significance of the data. A P value of < 0.05 was considered statistically significant.

Results:
Out of the 100 patients, 76 had good QOL and 24 had poor QOL. Among them, 67 patients were on a single drug, 27 were on a two-drug combination and six were on a three-drug combination for the management of glaucoma. Patients receiving multiple drugs for the management of POAG were associated with poor QOL (P = 0.006). Out of the other variables tested for association, the presence of ADRs, patients having a positive family history of POAG, patients with a duration of illness of more than three years, hypertensives and diabetics had a statistically significant association with poor QOL.

Conclusion:
POAG patients on multiple anti-glaucoma medications had poor QOL compared to those on a single drug. Multiple drug combinations caused a greater number of ADRs compared to single drug use. Patients with ADRs had poor QOL. The presence of co-morbidities like diabetes, hypertension and positive family history were associated with poor QOL.
Blepharochalasis and Lichen Planus Pigmentosus: A Very Rare Association
Authors: Das Sujit , Singh Sakshi , Mishra Ram Mohan , Yadav Mitali 
Published: July 2024

AbstractBlepharochalasis syndrome is a condition of the eyelids consisting of episodic inflammation and chronic skin changes. It is usually bilateral and tends to manifest in the upper eyelids. But, there are cases of unilateral presentation also which exclusively affects the lower eyelids. There are multiple theories regarding the etiology of blepharochalasis. Blepharochalasis is believed to be a manifestation of angioneurotic edema. Hormonal changes may play an important role in the disease process. Immunohistochemical analysis of excised eyelid skin has demonstrated the presence of IgA in several studies. These findings suggest that there may be a concomitant inflammatory process accompanying the extravasations’ of fluid and localized edema occurring at the capillary level. Blepharochalasis might also present as part of systemic disease. The disease, lichen planus pigmentosus, is a variant of lichen planus and has also been noted the presence of IgA and IgG along with complement C3 in the epidermal cells in several studies.
Trematode Granuloma: Journey of the Worm from the River Bed to the Agar Plate
Authors: Rajesh Vedhanayaki , Sivakumar Rathinam , Thundikandy Radhika 
Published: July 2024

Abstract
Trematode granuloma has been reported as one of the common causes of infectious uveitis in paediatric age group in recent times in Tamil Nadu. These granulomas occur after exposure to the trematode-infested water resources. Studies from South India have established the cause of granuloma as trematode by histopathological and molecular diagnostics. The smaller granulomas responded to topical and oral steroids while larger lesions needed surgical excision. Untreated cases develop retro corneal membrane, cataract, glaucoma and even phthisis in the long run. Early identification and prompt treatment are needed to prevent visual morbidity in these children.
The Making of Psychiatrists in Japan
Authors: Nakagami Yukako , Oya Nozomu , Horinouchi Toru , Aki Morio 
Published: July 2024

Abstract

Background:
Like in most countries in the world, Japan has its own system of how a medical graduate becomes a psychiatrist.

Methods:
The authors, young Japanese psychiatrists, describe what they have personally been through the education and training before becoming full-fledged psychiatrists who can treat patients with psychiatric diseases. All those personal experiences are validated with related documents.

Results:
In Japan, the pathway to become psychiatrists involves a rigorous process starting with a competitive entrance to medical school, followed by a six-year educational curriculum influenced by international accreditation standards. After graduating from medical schools, physicians receive a two-year junior residency training, which briefly introduces them to psychiatry, influencing some to specialize in the field. Specialization requires further training and certification, facilitated by the Japanese Society of Psychiatry and Neurology (JSPN) and the Ministry of Health, Labor, and Welfare, encompassing various psychiatric settings and disorders. Beyond initial certification, there are continuous professional development opportunities, including advanced specializations and educational programs supported by professional societies such as the JSPN and the Japan Young Psychiatrists Organization.

Conclusion:
This system ensures a comprehensive and structured approach to psychiatric education and specialization in Japan, offering a wide range of opportunities for aspiring psychiatrists.
Variations of Sleep Patterns and Their Relations with Positive and Negative Domains of Schizophrenia in Eastern Indian Population
Authors: Pal Amit Kumar , Kundu Partha Sarathi , Halder Arghya , Ray Sagarika , Bhattacharya Amit Kumar 
Published: July 2024

Abstract

Objectives:
Schizophrenia is a persistent and incapacitating psychiatric condition characterized by symptoms with positive, negative, affective, and cognitive domains. Sleep disturbances represent an important facet of this disorder, impacting both the quality of life and influencing its overall outcome. In the cross-sectional study, we intended to investigate the polysomnographic findings of patients with schizophrenia showing predominantly positive symptoms as opposed to those presenting with predominantly negative symptoms and also as compared to normal population.

Methods:
This study had a cross-sectional design, involving the recruitment of 60 medication-naive patients diagnosed with schizophrenia according to the ICD-10 criteria and 30 study participants representing normal population. The cases were subdivided into two groups: one characterized by predominantly positive symptoms and the other characterized by predominantly negative symptoms. Both the groups received overnight polysomnography, and study variables were recorded.

Results:
All the sleep parameters were deranged in patients with schizophrenia as compared to normal controls in the general population, with significantly more pronounced differences found in those with predominant positive symptoms for most variables (p < 0.001). The only exception was the duration of N3 (slow-wave sleep) which was significantly decreased in patients with negative symptoms compared to those with positive symptoms (p < 0.001). But no significant differences were found between the negative and positive symptom domain groups in mean rapid eye movement (REM) latency, duration of N1 and N2 sleep, and total percentage of REM sleep.

Conclusion:
This study highlights substantial variations in sleep patterns between the negative and positive symptom domains of schizophrenia and also as compared to the general population. Further study is imperative to explore the link between circadian integrity and symptoms of the various domains of schizophrenia.
The Effect of Listening to Pachelbel’s Canon in D Major on Anxiety Level during Pulmonary Rehabilitation: A Pilot Study
Authors: Fan Jui-Chia , Chao Ke-Yun , Wu Chia-Chun , Shih Yi-Nuo 
Published: July 2024

Abstract

Objective:
Many patients with chronic obstructive pulmonary disease (COPD) feel anxious during the pulmonary rehabilitation process. How to reduce the anxious level in patients with COPD is a worthy issue for mental health. Johann Pachelbel’s Canon is a commonly used musical material in clinical practice. In this pilot study, we intended to investigate the effectiveness of using Pachelbel’s Canon in D major as a music therapy to reduce anxiety levels in patients receiving pulmonary rehabilitation for chronic obstructive pulmonary disease (COPD).

Methods:
Fifty patients with COPD receiving pulmonary rehabilitation from a hospital in New Taipei City. They were randomly assigned in blocks for two groups, control group in a quiet environment, and experimental group listened to the Pachelbel’s canon in D major.

Results:
A significant difference in the anxiety score during pulmonary rehabilitation between the experimental group and the control group was found through an independent sample t-test in this study (p < 0.05).

Conclusion:
Listening to the music of Pachelbel’s canon in D Major decreased the anxiety level of patients with COPD during pulmonary rehabilitation.
Accessing Rehabilitation after Upper Limb Reconstructive Surgery in Cervical Spinal Cord Injury: A Qualitative Study
Authors: Randolph Samantha B. , L’Hotta Allison J. , Tam Katharine , Stenson Katherine C. , Curtin Catherine M. , James Aimee S. , Kennedy Carie R. , Ota Doug , Novak Christine B. , Kenney Deborah , Fox Ida K. 
Published: July 2024

Objectives:
To investigate the barriers and facilitators to rehabilitation experienced by individuals with cervical SCI after upper limb (UL) reconstructive surgery.

Methods:
We conducted a prospective cohort study with a follow-up period of up to 24 months. Data collection occurred at two academic and two Veterans Affairs medical centers in the United States. Participants were purposively sampled and included 21 adults with cervical SCI (c-SCI) who had received nerve or tendon transfer surgeries and 15 caregivers. We administered semi-structured interviews about participants’ experiences of accessing rehabilitation services after surgery.

Results:
Four themes emerged from the data: (1) participants encountered greater obstacles in accessing therapy as follow-up time increased; (2) practical challenges (e.g., insurance coverage, opportunity costs, transportation) limited rehabilitation access; (3) individuals with c-SCI and their caregivers desired more information about an overall rehabilitation plan; and (4) external support systems facilitated therapy access.

Conclusion:
Individuals with c-SCI experience multilevel barriers in accessing rehabilitation care after UL reconstructive surgeries in the United States. This work identifies areas of focus to mitigate these challenges, such as enhancing transparency about the overall rehabilitation process, training providers to work with this population, and developing, testing, and disseminating rehabilitation protocols following UL reconstruction among people with c-SCI.
Osteoporosis knowledge and awareness among rheumatoid arthritis patients: A cross-sectional controlled study
Authors: Tomay Aksoy Öykü , Kutluk Öznur , Sezer İlhan 
Published: July 2024

Objectives: The aim of this study was to investigate the levels of knowledge and awareness of osteoporosis (OP) in patients with rheumatoid arthritis (RA).
Patients and methods: The cross-sectional study included 100 RA patients (26 males, 74 females; mean age: 51±11 years; range, 28 to 67 years) who had not been diagnosed with OP and a control group of 50 healthy subjects (16 males, 34 females; mean age: 53±11 years; range, 29 to 70 years) between February 2022 and June 2022. The demographic data of age, sex, and education level of all the participants were recorded. Disease duration and the drugs used were recorded for the RA patients. The revised Osteoporosis Knowledge Test and the Osteoporosis Health Belief Scale questionnaires were completed by the participants.
Results: There was no significant difference determined between the RA patients and the control group in OP knowledge levels. A positive correlation was determined between education level and OP knowledge level and between disease duration and OP awareness level. RA patients with a family history of OP, those in the postmenopausal period, and those using biological disease-modifying drugs thought they were at risk of OP at a higher rate.
Conclusion: While the levels of knowledge and awareness of OP were determined to be similar in the RA patients and the control group, the vast majority of RA patients did not know that they were at risk of developing OP. In addition, when the data obtained in this study are taken into consideration, there appears to be a need for health strategies such as educational programs and informing RA patients about OP.
Prevalence and characteristics of juvenile fibromyalgia syndrome in pediatric rheumatic diseases: A comparative study
Authors: Özomay Baykal Gülcan , Kurtuluş Duygu , Ata Serap , Sözeri Betül 
Published: July 2024

Objectives: The study aimed to evaluate the frequency of juvenile fibromyalgia syndrome (JFMS) in patients diagnosed with juvenile idiopathic arthritis (JIA) and familial Mediterranean fever (FMF) with joint symptoms and compare them with a healthy control group.
Patients and methods: This retrospective study was conducted with 181 participants between January and April 2023. One hundred twenty-one patients with JIA or FMF diagnoses (71 females, 50 males; mean age: 15.6±2.1 years; range, 12 to 23 years) and 60 healthy individuals (36 females, 24 males; mean age: 14.5±1.6 years; range, 12 to 17 years) were included in the patient group and the control group, respectively. The pain and symptom assessment scale was applied for the JFMS diagnosis, and the output data were analyzed with the widespread pain index and symptom severity scale.
Results: Of the patient group, 57% (n=69) were diagnosed with FMF, and 43% (n=52) were diagnosed with JIA. When the two groups were compared with those diagnosed with JFMS, statistical significance was detected (p<0.05). Thirteen (87%) of those diagnosed with JFMS were female, and two (13%) were male, with a statistically significant difference.
Conclusion: In patients with JIA and FMF who complain of chronic musculoskeletal pain, tiredness, and weakness, JFMS diagnosis should always be considered in the clinical evaluation.
Genesis of criminalization of acts related to the restriction of competition
Authors: Федоров Ю.В. 
Published: July 2024

Статья содержит ретроспективный анализ законодательства, устанавливающего ответственность за совершение действий, направленных на ограничение конкуренции. В нормативных актах XIII–XVI вв. запреты мо- нополий были ориентированы на противодействие искусственному удержа- нию торговцами по взаимной договоренности завышенных цен на отдельные виды продовольственных товаров. Социальная недооценка степени опасно- сти действий, связанных с ограничением конкуренций, определяла казуич- ность нормативных предписаний, порицающих спекуляцию. Плановая эко- номика Советского государства исключала потребность уголовно-правового регулирования ограничения конкуренции. Впервые установив уголовную от- ветственность за действия, направленные на недопущение, ограничение или устранение конкуренции, в 1996 г., законодатель, снижая репрессивность за- прета, неоднократно редактировал положения ст. 178 УК РФ, сдерживая ее практическую реализацию.
The article contains a retrospective analysis of the legislation establishing liability for actions aimed at restricting competition. Reflected in the regulations of the XIII–XVI centuries, the prohibitions of monopolies were aimed at countering merchants’ artificial retention of inflated prices for certain types of food products by mutual agreement. Social underestimation of the degree of danger of actions related to the restriction of competition determined the casualness of regulations condemning speculation. The planned economy of the Soviet state excluded the need for criminal law regulation of competition restrictions. Having first established criminal liability for actions aimed at preventing, restricting or eliminating competition in 1996, the legislator, reducing the repressiveness of the ban, repeatedly edited the provisions of Article 178 of the Criminal Code of the Russian Federation, restraining its practical implementation.
PERENCANAAN STRATEGIS SISTEM INFORMASI PADA DINAS KOMUNIKASI DAN INFORMATIKA KABUPATEN CILACAP MENGGUNAKAN METODE WARD AND PEPPARD
Authors: Jayanto Marcelinus Tirta , Rahardja Yani 
Published: July 2024

Dinas Komunikasi dan Informatika bertanggung jawab atas penyelenggaraan urusan pemerintahan di bidang komunikasi, informatika, persandian, dan statistik. Untuk mencapai tujuan organisasi sebagaimana tertuang dalam visi dan misi, diperlukan strategi sistem informasi, teknologi informasi dan strategi bisnis. Melayani masyarakat merupakan tanggung jawab Satuan Kerja Perangkat Daerah (SKPD), perangkat daerah di pemerintah provinsi dan kabupaten. Penggunaan sistem informasi sangat penting untuk mendukung aktivitas internal di SKPD dan pelayanan publik. Diskominfo Kabupaten Cilacap harus mampu membuat rencana strategis sistem informasi yang selaras dengan strategi bisnis perusahaan untuk mewujudkannya. Untuk memaksimalkan kepentingan strategis sistem informasi dalam organisasi dan memberikan keunggulan kompetitif, kerangka kerja perencanaan strategis sistem informasi diperlukan saat membuat rencana strategis SI yang baik. Penulis penelitian ini akan menggunakan metode Ward and Peppard untuk mengembangkan rencana strategis sistem informasi yang akan diterapkan di Dinas Komunikasi dan Informatika Kabupaten Cilacap. Visi dan misi Dinas Komunikasi dan Informatika Kabupaten Cilacap ditelaah, beserta sasaran strategi bisnis perusahaan, sebagai bagian dari proses perencanaan strategis sistem informasi. Alat analisis yang digunakan dalam proses ini meliputi Value Chain, Strengths Weaknesses, Opportunity Threats (SWOT). Hasil dari pendekatan perencanaan strategis ini telah mengarah pada pembuatan portofolio aplikasi yang dipetakan menggunakan McFarlan Strategic Grid. Tujuan dari penelitian ini adalah memanfaatkan teknologi informasi dan sistem informasi untuk memberikan pelayanan publik yang lebih baik kepada masyarakat dan meningkatkan efisiensi kerja pegawai/unsur pimpinan dalam proses pengambilan keputusan.
K. N. Leontiev in the epistolary chronicle of the St. Andrew’s Skete on Mount Athos (1871–1874)
Authors: Талалай М.Г. , Фетисенко О.Л. 
Published: July 2024

В статье подробно рассмотрена неизвестная страница биографии К. Н. Леонтьева — история его пребывания в Андреевском скиту и взаимоотношений со старшей братией этой обители. Материалом послужили недавно обнаруженные в архиве скита, ныне хранящемся в монастыре Ватопед, письма Леонтьева и многочисленные упоминания о нем, выявленные в переписках игумена Феодорита (Крестовникова). Эти документы содержат множество ценных подробностей о самом важном периоде жизни писателя, начавшемся после его религиозного обращения.
K. N. Leontiev’s stay in the Athonite St. Andrew’ Skete in 1871–1872 is an unknown page of his biography. Unique sources discovered in the skete’s archive cover this period in almost detail. The article is based on these sources.
Pengaruh Meaning of Work Terhadap Work Engagement Pada Pengasuh di Panti Sosial
Authors: Amalina Dina , Ariani Lita , Julaibib Julaibib 
Published: July 2024

Pengasuh memiliki peran penting dalam memberikan perawatan dan pelayanan kepada lansia di Panti Sosial. Pengasuh juga memiliki tugas pekerjaan yang tidak sedikit, namun pengasuh tetap berkontribusi dalam pekerjaannya secara sukarela tanpa adanya batasan waktu dan tidak dihitung sebagai lembur. Walaupun demikian, pengasuh tetap menjalankan tugas mereka dengan baik karena sudah menganggap lansia memiliki peran tersendiri bagi mereka sehingga pekerjaan tersebut memiliki suatu makna bagi pengasuh. Tujuan dari penelitian ini adalah untuk melihat pengaruh meaning of work terhadap work engagement pada pengasuh di panti sosial. Penelitian ini menggunakan pendekatan kuantitatif dengan desain penelitian korelasional. Data akan dianalisis menggunakan regresi linear sederhana dengan bantuan software SPSS (Statistical Package for the Social Sciences) versi 29.0. Hasil analisis menunjukkan adanya pengaruh positif signifikan, semakin tinggi meaning of work pengasuh, maka semakin meningkat pula work engagement. Diharapkan hasil dari penelitian ini dapat diimplementasikan dalam organisasi untuk meningkatkan work engagement dan mengoptimalkan persepsi terkait meaning of work.
The useful of Animation Media TPACK-Based in Economic Subject Material to Build Critical Thinking Ability
Authors: Azhari Dila , Tanjung Samsidar , Yus Anita 
Published: July 2024

This study aims to analyze the feasibility, practicality, and effectiveness of TPACK-based animated media on economic activity material to improve critical thinking skills of grade IV students at UPT SPF SDN 101774 Sampali. This media development uses the 4D (four-D) research model, which includes the define, design, develop, and disseminate stages. The research subjects consisted of material expert validators, media experts, teachers, and 30 students. Data collection techniques in this study by conducting unstructured interviews with teachers and students and questionnaire sheets consisting of questionnaire sheets for media experts, material experts, grade IV teachers, and students. The analysis technique used in this research is product feasibility test analysis, product effectiveness test analysis, and product practicality test analysis. The developed media proved to be feasible, practical, and effective as learning media. Validation results from material experts showed 84% (feasible) at stage I and 90% (very feasible) at stage II, while validation from media experts showed 98% (very feasible) at stage I. The practicality test for teachers and students showed an average percentage of practicality of 92.6% from students and 92% from teachers, with an overall average of 92.3% (very practical). Finally, the effectiveness test of TPACK-based animated media in improving students' critical thinking skills has increased significantly, with a pretest score of 48 and increased during the post test of 86 and the results of the gain test show a value of 0.73 which is categorized as high. Thus, the TPACK-based animation media developed is declared feasible, practical, and effective for use in improving students' critical thinking skills and can be used as a new breakthrough in the utilization of digital technology in 21st century learning because this media not only utilizes technology to improve the quality of learning, but also integrates pedagogy and content relevant to the needs of today's students.