bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate governance, reporting quality, and firm value: evidence from Indonesia
Authors: Siagian Ferdinand , Siregar Sylvia V. , Rahadian Yan 
Published: February 2013

PurposeThe purpose of this paper is to investigate whether corporate governance practices and the quality of reporting are associated with firm value for public firms in Indonesia.Design/methodology/approachThe authors hypothesize that there are positive associations between firm value and corporate governance practices and reporting quality. For the authors’ proxies for corporate governance and reporting quality they develop two new indices. First, they develop a corporate governance index (the CGI) to measure corporate governance practices by Indonesian firms. Second, they develop a reporting quality index (the RQI) to measure the firms’ quality of reporting and disclosures. To examine the associations the authors run multivariate regressions of their proxies for firm value on the two indices.FindingsConsistent with the first hypothesis, the paper finds positive associations between corporate governance and different proxies of firm value. These findings suggest that firms that implement better corporate governance have higher values. Contrary to the second hypothesis, the paper finds negative associations between reporting quality and the proxies for firm value. These findings indicate that lower value firms tend to disclose more information that is consistent with the P3LKE than higher value firms.Research limitations/implicationsThe results suggest that corporate governance practice by Indonesian public firms is value relevant and therefore, should provide incentives to the firms to improve their governance. This shows that the Indonesian government's efforts to promote corporate governance provide benefits to publicly traded firms. The results also indicate that firms with low values are more likely to disclose information that is consistent with the P3LKE. This warrants further research because this finding is inconsistent with the contention that more disclosures should result in higher value.Practical implicationsThe authority needs to put more efforts in promoting good corporate governance implementations and making sure that public firms improve their disclosures and reporting quality in order to provide benefits to the users of financial information.Originality/valueCorporate governance index for public firms is not readily available in Indonesia. Therefore, the authors develop an index to measure corporate governance implementations by Indonesian public firms. To the authors’ knowledge, this is the first paper that develops an index to measure adherence to the P3LKE, which is a comprehensive measure of the quality of reporting.
Nasal carriage of Staphylococcus aureus in patients undergoing Mohs micrographic surgery is an important risk factor for postoperative surgical site infection: A prospective randomised study
Authors: Tai Yee J , Borchard Kate LA , Gunson Todd H , Smith Harvey R , Vinciullo Carl 
Published: February 2013

AbstractBackgroundSurgical site infection (SSI) can be a problematic complication of Mohs micrographic surgery (MMS). Previous reports have cited nasal Staphylococcus aureus (S. aureus) carriage as a risk factor for SSI, but none thus far in dermatologic surgery.ObjectiveThe aim was to determine the difference in infection rates between nasal carriers of S. aureus and non‐carriers, and whether decolonisation with intranasal mupirocin ointment and chlorhexidine wash would reduce the infection rate in nasal carriers.MethodsIn all, 738 patients presenting for MMS at the Oxford Day Surgery and Dermatology underwent a nasal swab to determine their S. aureus carriage status. S. aureus carriers were randomised for decolonisation with intranasal mupirocin ointment and chlorhexidine body wash. Non‐carriers were untreated. All patients were followed up for SSI.ResultsThe rate of SSI was 11 per cent in untreated S. aureus carriers, 4 per cent in treated carriers, and 3 per cent in non‐carriers. The difference in infection rate between carriers and non‐carriers was significant (P < 0.001). The difference between treated and untreated carriers was also significant (P = 0.05).ConclusionNasal S. aureus carriage is an important risk factor for SSI in MMS, conferring an over threefold increase in SSI risk. A pre‐operative nasal swab provides a simple and effective risk stratification tool. The use of a topical decolonisation regimen reduces the infection rate in carriers to a level approaching non‐carriers without exposure to systemic antibiotics.
Hypomelanosis of Ito and multiple naevoid hypertrichosis: Rare cutaneous mosaicism
Authors: Khurana Ananta , Singal Archana , Pandhi Deepika 
Published: February 2013

AbstractHypomelanosis of Ito and naevoid hypertrichosis are both uncommon disorders and their coexistence in the same patient is rarely described. Most previously reported patients, in addition to cutaneous lesions, had multiple neurological, musculoskeletal and other organ system involvements. We present the case of a 3‐year‐old girl with these two naevoid disorders at sites completely exclusive of each other and without any severe associated defects.
The use of prophylactic gastroprotective therapy in patients with nonsteroidal anti‐inflammatory drug‐ and aspirin‐associated ulcer bleeding: a cross‐sectional study
Authors: Ho C. W. , Tse Y. K. , Wu B. , Mulder C. J. J. , Chan F. K. L. 
Published: February 2013

SummaryBackgroundPoor adherence to gastroprotective agents (GPAs) is common among users of nonsteroidal anti‐inflammatory drugs (NSAIDs) or low‐dose aspirin (ASA). There are little data on the utilization of GPAs among NSAID and ASA users complicated by ulcer bleeding.AimTo study the utilization of GPA among NSAID and ASA ulcers before the onset of ulcer bleeding.MethodsWe conducted a cross‐sectional study to determine the exposure to NSAIDs, ASA, and GPAs within 4 weeks before endoscopically confirmed ulcer bleeding. Sensitivity analysis was performed to study how improving adherence to GPA use would reduce the risk of ulcer bleeding in high‐risk users.ResultsBetween 2000 and 2009, 1093 and 2277 patients had NSAID‐ and ASA‐associated ulcer bleeding respectively. The incidence of NSAID‐associated ulcer bleeding declined by 40%, whereas that of ASA‐associated ulcer bleeding increased by 46%. Thirty‐nine per cent of NSAID users and 75% of ASA users belonged to high ulcer risk category. Although GPA prescription rate has increased over time, only 41.6% and 30.6% of high‐risk NSAID and ASA users received GPAs before ulcer bleeding respectively. Sensitivity analysis showed that if GPAs could reduce bleeding risk by 50%, improving adherence would prevent up to 35% of ulcer bleeding in high‐risk users.ConclusionsA substantial proportion of high‐risk NSAID and ASA users had not received prophylaxis with gastroprotective agents before ulcer bleeding. These bleeding episodes may be preventable with better adherence to gastroprotective agent use.
Long‐term effects of melatonin on quality of life and sleep in haemodialysis patients (Melody study): a randomized controlled trial
Authors: Russcher Marije , Koch Birgit C. P. , Nagtegaal J. Elsbeth , van Ittersum Frans J. , Pasker‐de Jong Pieternel C. M. , Hagen E. Chris , van Dorp Wim Th , Gabreëls Bas , Wildbergh Thierry X. , van der Westerlaken Monique M. L. , Gaillard Carlo A. J. M. , ter Wee Piet M. 
Published: February 2013

AimThe disturbed circadian rhythm in haemodialysis patients results in perturbed sleep. Short term melatonin supplementation has alleviated these sleep problems. Our aim was to investigate the effects of long‐term melatonin supplementation on quality of life and sleep.MethodsIn this randomized double‐blind placebo‐controlled trial haemodialysis patients suffering from subjective sleep problems received melatonin 3 mg day−1 vs. placebo during 12 months. The primary endpoint quality of life parameter ‘vitality’ was measured with Medical Outcomes Study Short Form‐36. Secondary outcomes were improvement of three sleep parameters measured by actigraphy and nighttime salivary melatonin concentrations.ResultsSixty‐seven patients were randomized. Forty‐two patients completed the trial. With melatonin, no beneficial effect on vitality was seen. Other quality of life parameters showed both advantageous and disadvantageous effects of melatonin. Considering sleep, at 3 months sleep efficiency and actual sleep time had improved with melatonin compared with placebo on haemodialysis days (difference 7.6%, 95% CI 0.77, 14.4 and 49 min, 95% CI 2.1, 95.9, respectively). At 12 months none of the sleep parameters differed significantly from placebo. Melatonin salivary concentrations at 6 months had significantly increased in the melatonin group compared with the placebo group.ConclusionsThe high drop‐out rate limits the strength of our conclusions. However, although a previous study reported beneficial short term effects of melatonin on sleep in haemodialysis patients, in this long‐term study the positive effects disappeared during follow up (6–12 months). Also the quality of life parameter, vitality, did not improve. Efforts should be made to elucidate the mechanism responsible for the loss of effect with chronic use.
Comparative analysis between azacitidine and decitabine for the treatment of myelodysplastic syndromes
Authors: Lee Yun‐Gyoo , Kim Inho , Yoon Sung‐Soo , Park Seonyang , Cheong June Won , Min Yoo Hong , Lee Jeong‐Ok , Bang Soo‐Mee , Yi Hyeon Gyu , Kim Chul Soo , Park Yong , Kim Byung‐Soo , Mun Yeung‐Chul , Seong Chu‐Myoung , Park Jinny , Lee Jae Hoon , Kim Sung‐Yong , Lee Hong Ghi , Kim Yeo‐Kyeoung , Kim Hyeoung‐Joon 
Published: February 2013

SummaryThe present study aimed to directly compare the efficacy and safety of azacitidine and decitabine in patients with myelodysplastic syndromes (MDS). We compared the overall response rate (ORR) (complete responses, partial responses, marrow complete responses, and haematological improvements), overall survival (OS), event‐free survival (EFS), time to leukaemic transformation, and adverse outcomes between azacitidine and decitabine. To minimize the effects of treatment selection bias in this observational study, adjustments were made using the propensity‐score matching method. Among 300 patients, 203 were treated with azacitidine and 97 with decitabine. Propensity‐score matching yielded 97 patient pairs. In the propensity‐matched cohort, there were no significant differences between the azacitidine and decitabine groups regarding ORR (44% vs. 52%), OS (26 vs. 22·9 months), EFS (7·7 vs. 7·0 months), and rate of leukaemic transformation (16% vs. 22% at 1 year). In patients ≥65 years of age, survival was significantly better in the azacitidine group (P = 0·017). Patients who received decitabine experienced more frequent episodes of grade 3 or 4 cytopenia and infectious episodes. We found that azacitidine and decitabine showed comparable efficacy. Among patients ≥65 years of age, survival was significantly better in the azacitidine group (ClinicalTrials.gov Identifier: NCT01409070).
Feasibility of the virtual needle tracking system for percutaneous radiofrequency ablation of hepatocellular carcinoma
Authors: Tomonari Akiko , Tsuji Kunihiko , Yamazaki Hajime , Aoki Hironori , Kang Jong‐Hon , Kodama Yoshihisa , Sakurai Yasuo , Maguchi Hiroyuki 
Published: February 2013

AimTo evaluate the feasibility of the real‐time virtual needle tracking system for percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).MethodsAn electromagnetic field created by an ultrasound (US) machine detected the tracking bracket mounted onto the RFA needle. When the needle tip was confirmed to be in the accurate plane extracorporeally, the needle was inserted into the liver using the virtual navigation US system, and RFA was performed. Eight patients with eight liver lesions underwent percutaneous RFA under ultrasound for HCC from October to November 2012 using the real‐time electromagnetic virtual needle tracking system (VirtuTRAX).ResultsThe average size of the tumors was 11.5 mm with one lesion in S4, two in S5, two in S7 and three in S8. Sufficient margins were obtained in a single session in all cases. Using only B‐mode, the needle tip was obscured due to the condition of the surrounding liver or subcutaneous fat tissue, but it was identifiable with the use of the virtual needle tracking device in all cases. In one case where the lesion was large, the needle was placed twice deliberately, but the second puncture was made difficult by the ablation artifact of the first puncture. With the tracking device, however, it was possible to perform the second puncture accurately.ConclusionThe virtual tracking system is useful in cases where the needle tip is obscured due to surrounding liver conditions or when multiple punctures are necessary due to the ablation artifact's obscuring the needle tip. Freehand puncturing may be possible in the future using this technique with further improvements in the system.
Time trends of assessments for medical dispute cases in Taiwan: a 20‐year nationwide study
Authors: Wu C.‐Y. , Weng H.‐C. , Chen R.‐C. 
Published: February 2013

AbstractBackgroundIn Taiwan, nearly all medical dispute cases were reviewed by an official Medical Review Committee (MRC).AimsThe aim of this study was to investigate the time trends of assessment reports by the MRC to estimate the changing trends of medical malpractice litigation.MethodsAll assessment reports of the MRC from a nationwide database were reviewed. The assessment reports were analysed according to the year of completion. We further analysed the time trends by adjusting numbers for the size of the general population and numbers of physicians. Stratified analyses were also conducted by region and commission authority.ResultsBetween 1987 and 2006, the MRC completed a total of 5324 assessment reports, with 4949 reports involving a medical dispute and the remaining 375 reports not involving a medical dispute. The numbers of assessment reports increased from 139 in 1987 to 221 in 1996 and 361 in 2006. The assessment increased from 0.70 per 100 000 people in 1987 to 1.03 and 1.58 per 100 000 people in 1996 and 2006 respectively. There was a stable trend of 8.5–10.0 assessments per 1000 physicians annually during the study period. Rising trends were consistent for all regions of Taiwan and for all criminal cases, but increases were more significant for civil cases.ConclusionsThe numbers of medical dispute cases have increased significantly over the past 20 years. More studies to investigate the reasons of the rising trends and to find resolving methods to decrease the numbers of medical dispute will be helpful in the future.
Development and validation of diabetes empowerment questionnaire in Iranian people with type 2 diabetes
Authors: Aghili R. , Khamseh M.E. , Malek M. , Banikarimi A.S. , Baradaran H.R. , Ebrahim Valojerdi A. 
Published: February 2013

BackgroundDiabetes self‐management education programmes which have been reported to improve the self‐efficacy of diabetic people can lead to their empowerment. Specialized diabetes nurses also play a fundamental role in empowering patients with diabetes through improving their knowledge and self‐care.AimThe purpose of this study was to develop a valid and reliable questionnaire to measure empowerment in Iranian people with type 2 diabetes.MethodsImportant subscales of patient empowerment were identified by an expert panel. The subscales included active self‐care, coping with personal and social concerns, basic knowledge related to diabetes management and patient‐physician communication. Questions related to each subscale were generated and the expert panel renewed the questionnaire to ensure relevance and clarity of the items. Patient focus groups were conducted to establish the face validity of the questionnaire. The final questionnaire consisted of 15 items organized in three subscales.In a population‐based study, a sample of 378 people with type 2 diabetes was recruited. Reliability coefficient (Cronbach's α) was calculated for all of the subscales. Convergent validity was assessed by Pearson's product moment correlation. The scree test was used to select significant subscales.FindingsTwo hundred forty‐seven female and 131 male subjects with type 2 diabetes filled out the questionnaire. Three subscales were derived from factor analysis considering item‐component loading of 0.4 as significant: ‘active self‐care’ (Cronbach's α: 0.78), ‘basic knowledge related to diabetes management’ (Cronbach's α: 0.72) and ‘coping with personal and social concerns’ (Cronbach's α: 0.51).The scree plot of the eigenvalues of 15 items proposed three subscale solutions. Internal consistency reliabilities for the three subscales were acceptable (α: 0.51–0.78).ConclusionsThe Diabetes Empowerment Questionnaire is a reliable and valid tool to assess patient empowerment in Iranian people with type 2 diabetes.
Motivation for physical activity in young adults with physical disabilities during a rehabilitation stay: a longitudinal test of self‐determination theory
Authors: Saebu Martin , Sørensen Marit , Halvari Hallgeir 
Published: February 2013

AbstractWe tested a self‐determination theory (SDT) process model during a 3 week physical activity rehabilitation stay among young adults with a physical disability (N = 44, Mage = 24.7, SD = 5.1). As hypothesized, perceived autonomy support positively predicted needs satisfaction at the end of the stay (r = .38, p < .01). Further, needs satisfaction was positively linked to changes in autonomous motivation for physical activity (r = .47, p < .01). Both changes in autonomous motivation and self‐efficacy were associated with physical activity increases over the stay (r = .57, p < .01 and r = .47, p < .01, respectively). Bootstrapping results supported the SDT process model, indicating a support for a development toward more self‐determined motivation in rehabilitation.
Feeding ecology of two lanternfishes Diaphus garmani and Diaphus chrysorhynchus
Authors: Tanaka H. , Sassa C. , Ohshimo S. , Aoki I. 
Published: February 2013

The feeding ecology of two dominant lanternfishes Diaphus garmani and Diaphus chrysorhynchus was studied in the continental slope region of the East China Sea, off western Kyushu (31–33° N; 128–130° E). Stomach contents of D. garmani were composed mainly of crustacean zooplankton, such as copepods, euphausiids, decapod larvae and amphipods, and also of appendicularians. Stomach contents of D. chrysorhynchus were composed mainly of crustacean zooplankton, cephalopods and fishes. Diel changes in stomach fullness indicated that D. garmani fed more actively at night than in the day. On the other hand, although feeding activity of D. chrysorhynchus did not change drastically between day and night, it tended to feed on large prey items in the benthopelagic zone during the day and on zooplankton in the epipelagic zone at night. Daily rations of food were estimated to be 2·54% of body dry mass for D. garmani, and 2·38% of body dry mass for D. chrysorhynchus.
p21‐activated kinase‐2 is a critical mediator of transforming growth factor‐β‐induced hepatoma cell migration
Authors: Sato Munehiro , Matsuda Yasunobu , Wakai Toshifumi , Kubota Masayuki , Osawa Mami , Fujimaki Shun , Sanpei Ayumi , Takamura Masaaki , Yamagiwa Satoshi , Aoyagi Yutaka 
Published: February 2013

AbstractBackground and AimTransforming growth factor‐β (TGF‐β) has been shown to play a central role in the promotion of cell motility, but its functional mechanism has remained unclear. With the aim of investigating the diagnostic and treatment modalities for patients with hepatocellular carcinoma (HCC), the signaling pathway that may contribute to TGF‐β‐mediated cell invasion in hepatoma cells was evaluated.MethodsThree hepatoma cell lines, HepG2, PLC/PRF/5, and HLF, were treated with TGF‐β, and the involvement of the non‐canonical TGF‐β pathway was analyzed by cell migration assays. HepG2 cells were treated with a p21‐activated kinase‐2 (PAK2)‐targeting small interfering RNA and analyzed for their cell motility. The relationships between the PAK2 status and the clinicopathological characteristics of 62 HCC patients were also analyzed.ResultsThe cell migration assays showed that Akt is a critical regulator of TGF‐β‐mediated cell migration. Western blotting analyses showed that TGF‐β stimulated Akt and PAK2 in all three hepatoma cell lines, and phosphorylated PAK2 was blocked by Akt inhibitor. Suppression of PAK2 expression by small interfering RNA resulted in increased focal adhesions with significantly repressed cell migration in the presence of TGF‐β. Clinicopathological analyses showed that the phosphorylation level of PAK2 was closely associated with tumor progression, metastasis, and early recurrence of HCC.ConclusionsPAK2 may be a critical mediator of TGF‐β‐mediated hepatoma cell migration, and may represent a potential target for the treatment of HCC.
Feeling rejected or invited: Experiences of persons seeking care advice at the Swedish Healthcare Direct organization
Authors: Winneby Ewa , Flensner Gullvi , Rudolfsson Gudrun 
Published: February 2013

AbstractAimSwedish Healthcare Direct is an organization staffed by registered nurses who act as telenurses and assess callers' need for care, taking both medical and personal aspects into account. They direct the care seeker to: emergency care (level I), a care center on duty (level II), their regular doctor (level III), or provide advice about self‐care strategies (level IV). In this assessment process, the nurse and care seeker should reach mutual agreement. The aim and focus of the present study was to elucidate the care seeker's situation and experiences of the care received after being triaged and directed to level II, although the telenurse in fact assessed their medical problems as corresponding to level III.MethodsA total of eight recent Swedish Healthcare Direct users were interviewed in this qualitative study. Data were analyzed by means of content analysis.ResultsThree themes emerged – “feeling trapped”, “feeling disrespected”, and “feeling invited” – comprising seven subthemes.ConclusionCare seekers experienced suffering as well as struggling to be allowed to be a patient. When not met by an ethically correct stance, they continued to seek care. In contrast, when they encountered commitment and an ethically correct attitude, their health process began and they had no further need for contact.