bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital Accreditation Status and Treatment Differences Among Black Patients With Colon Cancer
Authors: Chan Kelley , Palis Bryan E. , Cotler Joseph H. , Janczewski Lauren M. , Weigel Ronald J. , Bentrem David J. , Ko Clifford Y. 
Published: August 2024

ImportanceHospital-level factors, such as hospital type or volume, have been demonstrated to play a role in treatment disparities for Black patients with cancer. However, data evaluating the association of hospital accreditation status with differences in treatment among Black patients with cancer are lacking.ObjectiveTo evaluate the association of Commission on Cancer (CoC) hospital accreditation status with receipt of guideline-concordant care and mortality among non-Hispanic Black patients with colon cancer.Design, Setting, and ParticipantsThis population-based cohort study used the National Program of Cancer Registries, which is a multicenter database with data from all 50 states and the District of Columbia, and covers 97% of the cancer population in the US. The participants included non-Hispanic Black patients aged 18 years or older diagnosed with colon cancer between January 1, 2018, and December 31, 2020. Race and ethnicity were abstracted from medical records as recorded by health care facilities and practitioners. The data were analyzed from December 7, 2023, to January 17, 2024.ExposureCoC hospital accreditation.Main Outcome and MeasuresGuideline-concordant care was defined as adequate lymphadenectomy during surgery for patients with stages I to III disease or chemotherapy administration for patients with stage III disease. Multivariable logistic regression models investigated associations with receipt of guideline-concordant care and Cox proportional hazards regression models assessed associations with 3-year cancer-specific mortality.ResultsOf 17 249 non-Hispanic Black patients with colon cancer (mean [SD] age, 64.8 [12.8] years; 8724 females [50.6%]), 12 756 (74.0%; mean [SD] age, 64.7 [12.8] years) were treated at a CoC-accredited hospital and 4493 (26.0%; mean [SD] age, 65.1 [12.5] years) at a non–CoC-accredited hospital. Patients treated at CoC-accredited hospitals compared with those treated at non–CoC-accredited hospitals had higher odds of receiving guideline-concordant lymphadenectomy (adjusted odds ratio [AOR], 1.89; 95% CI, 1.69-2.11) and chemotherapy (AOR, 2.31; 95% CI, 1.97-2.72). Treatment at CoC-accredited hospitals was associated with lower cancer-specific mortality for patients with stages I to III disease who received surgery (adjusted hazard ratio [AHR], 0.87; 95% CI, 0.76-0.98) and for patients with stage III disease eligible for chemotherapy (AHR, 0.75; 95% CI, 0.59-0.96).Conclusions and RelevanceIn this cohort study of non-Hispanic Black patients with colon cancer, patients treated at CoC-accredited hospitals compared with those treated at non–CoC-accredited hospitals were more likely to receive guideline-concordant care and have lower mortality risk. These findings suggest that increasing access to high-quality guideline-concordant care at CoC-accredited hospitals may reduce variations in cancer treatment and outcomes for underserved populations.
Virtual Learning in Kindergarten Through Grade 12 During the COVID-19 Pandemic and Chronic Absenteeism
Authors: Evans William N. , Muchnick Kathryn , Rosenlund Olivia 
Published: August 2024

ImportanceChronic absenteeism among kindergarten through grade 12 students has increased considerably after the COVID-19 pandemic.ObjectiveTo examine the association between virtual learning during the 2020-2021 school year and chronic absenteeism during the 2021-2022 school year at the school district level.Design, Setting, and ParticipantsThis cross-sectional study used a panel of 11 017 school districts throughout the US comprising kindergarten through grade 12 for the 2018-2019 and 2021-2022 school years.ExposuresThe key covariates were the percentage of hybrid and virtual school days in the previous school year, with an assumption that these values in the 2018-2019 school year were zero.Main Outcome and MeasuresChronic absenteeism rates at the district level, which were regressed on the percentage of school days in a learning mode in the previous school year, demographic characteristic and socioeconomic status controls, plus district and year fixed effects. Observations were weighted by district enrollment, and SEs were clustered at the district level.ResultsThe dataset includes 11 017 school districts for 2 years and 22 034 observations. Chronic absenteeism rates increased by 13.5 percentage points, from a mean (SD) of 15.9% (8.1%) in the 2018-2019 school year to 29.4% (13.2%) in the 2021-2022 school year. Students whose schools had 100% virtual instruction during the COVID-19 pandemic had chronic absenteeism rates that were 6.9 percentage points (95% CI, 4.8-8.9 percentage points) higher than those that were 100% in person. Hybrid instruction was not associated with increased absenteeism. The association between virtual learning and chronic absenteeism varied by socioeconomic status, with the conditional correlation much larger for at-risk students; chronic absenteeism rates were 10.6 percentage points (95% CI, 7.2-14.1 percentage points) higher among students with 100% of days in virtual learning from districts in the top quintile of poverty rates compared with 100% in-persion districts.Conclusions and RelevanceIn this cross-sectional study, chronic absenteeism rates were substantially higher in school districts that used virtual learning during the COVID-19 pandemic compared with in person. Understanding how to reduce chronic absenteeism and use virtual learning without potentially negative consequences are key policy questions moving forward.
Aging Influences Fracture Healing on the Cellular Level and Alters Systemic RANKL and OPG Concentrations in a Murine Model
Authors: Zhang Tianqi , Neunaber Claudia , Ye Weikang , Wagner Alessa , Bülow Jasmin Maria , Relja Borna , Bundkirchen Katrin 
Published: August 2024

AbstractClinical complications frequently follow polytrauma and bleeding fractures, increasing the risk of delayed fracture healing and nonunions, especially in aged patients. Therefore, this study examines age's impact on fracture repair with and without severe bleeding in mice. Young (17–26 weeks) and aged (64–72 weeks) male C57BL/6J mice (n = 72 in total, n = 6 per group) are allocated into 3 groups: the fracture group (Fx) undergoes femur osteotomy stabilized via external fixator, the combined trauma group (THFx) additionally receives pressure‐controlled trauma hemorrhage (TH) and Sham animals are implanted with catheter and fixator without blood loss or osteotomy. Femoral bones are evaluated histologically 24 h and 3 weeks post‐trauma, while RANKL/OPG and β‐CTx are measured systemically via ELISA after 3 weeks. Aging results in less mineralized bone and fewer osteoclasts within the fracture of aged mice in contrast to young groups after three weeks. Systemically, aged animals exhibit increased RANKL and OPG levels after fracture compared to their young counterparts. The RANKL/OPG ratio rises in aged Fx animals compared to young mice, with a similar trend in THFx groups. In conclusion, age has an effect during the later course of fracture healing on the cellular and systemic levels.
Decoding the Role of NEIL1 Gene in DNA Repair and Lifespan: A Literature Review with Bioinformatics Analysis
Authors: Mohajeri Khorasani Amirhossein , Raghibi Alireza , Haj Mohammad Hassani Behzad , Bolbolizadeh Pedram , Amali Arian , Sadeghi Mahboubeh , Farshidi Narges , Dehghani Aghdas , Mousavi Pegah 
Published: August 2024

AbstractLongevity, the length of an organism's lifespan, is impacted by environmental factors, metabolic processes, and genetic determinants. The base excision repair (BER) pathway is crucial for maintaining genomic integrity by repairing oxidatively modified base lesions. Nei‐like DNA Glycosylase 1 (NEIL1), part of the BER pathway, is vital in repairing oxidative bases in G‐rich DNA regions, such as telomeres and promoters. Hence, in this comprehensive review, it have undertaken a meticulous investigation of the intricate association between NEIL1 and longevity. The analysis delves into the multifaceted aspects of the NEIL1 gene, its various RNA transcripts, and the diverse protein isoforms. In addition, a combination of bioinformatic analysis is conducted to identify NEIL1 mutations, transcription factors, and epigenetic modifications, as well as its lncRNA/pseudogene/circRNA‐miRNA‐mRNA regulatory network. The findings suggest that the normal function of NEIL1 is a significant factor in human health and longevity, with defects in NEIL1 potentially leading to various cancers and related syndromes, Alzheimer's disease, obesity, and diabetes.
Multi‐Hierarchical Fe Single Atom Nanozymes with Axially‐Coordinated O‐Fe‐N4 Active Centers Reshape Macrophage Epigenetics Against Immunosuppression
Authors: Wang Qin , Zhu Xiaoqi , Yin Binxu , Yan Kangning , Qiu Guanhua , Liang Xiayi , Jia Ruonan , Chen Jie , Wang Xiaobo , Wu Yafei , Liu Junjie , Zhong Jingping , Zhang Kun , Wang Duo 
Published: August 2024

AbstractImmunosuppression is ubiquitous in solid tumors, characterized by few cytotoxic T infiltrations, abundant inflammation enrichment, immunosuppressive cell recruitment, etc., which is especially potentiated by incomplete tumor resection. In this report, multi‐hierarchical Fe single‐atom nanozymes (SAzymes) featuring axially‐coordinated O‐Fe‐N4 active centers are constructed to reshape tumor‐associated macrophages (TAMs) epigenetics via repolarizing their phenotypes, which is highly profitable for mitigating tumor immunosuppression after incomplete radiofrequency ablation (iRFA). Therein, a nitrogen‐doped bamboo‐like carbon nanotube (N‐BCNT) is engineered to coordinatively immobilize Fe atoms, wherein another axial coordination (O) is introduced to further switch non‐polar Fe‐N4 to polar O‐Fe‐N4. The polarization switching of active centers synergies with N doping‐encouraged electron transport, low‐temperature synthesis‐discouraged N loss and large surface area‐unlocked O‐Fe‐N4 enrichment to confer tetra‐enzymic catalysis activities including peroxidase, oxidase, catalase, and glutathione oxidase, maximumly favoring reactive oxygen species (ROS) production and hypoxia reversal. After delivering TAMs polarization‐encouraged drug, toosendanin, TAMs epigenetics are altered and their phenotypes are repolarized to relieve immunosuppression and magnify immune responses, which suppress residual tumor progression after iRFA. Such a comprehensive structure optimization strategy provides a versatile route to design and construct SAzymes‐like drugs with multi‐enzymatical catalysis activities.
Dual‐Modal Stretchable Sensing Patches for In Situ Monitoring of Electromyography and Acoustic Myography
Authors: Li Tengfei , Zhao Hang , Li Hanfei , Zhang Zhibo , Han Fei , Fang Peng , Li Guanglin , Xie Ruijie , Li Qingsong , Gao Xuhe , Hu Changtao , Gong Jianhong , Liu Zhiyuan , Tian Qiong 
Published: August 2024

AbstractElectromyography (EMG) and acoustic myography (AMG) play crucial roles in assessing muscle function, providing valuable insights into neural control, muscle activation, and fatigue levels. However, the current landscape reveals a gap in dual‐modal stretchable sensing patches, highlighting the need for comfortable and wearable solutions in the field of in situ monitoring of synchronous EMG and AMG sensing. In this work, a dual‐modal stretchable patch (DMSP) is developed that fully integrates a multi‐channel EMG electrode with AMG sensors. It possesses stable electromechanical properties even at strains exceeding 200%. With an overall modulus of under 40 kPa and a skin adhesion force surpassing 30 N m−1, the DMSP exhibits exceptional durability, enduring 1000 stretching cycles. The DMSP enables in situ simultaneous monitoring of EMG and AMG signals from sternocleidomastoid muscle during neck rotation where the mechanical strain reaches up to 30%. The DMSP proves instrumental in characterizing muscle activity, facilitating in‐depth research on muscle movement, and thus enhancing clinical outcomes in rehabilitation medicine and physical therapy.
Regulation of Molecular Microheterogeneity in Electrolytes Enables Ampere‐Hour‐Level Aqueous LiMn2O4||Li4Ti5O12 Pouch Cells
Authors: Zhang Canfu , Chen Binbin , Chen Qinlong , Liu Yingchun , Kong Xueqian , Suo Liumin , Lu Jun , Pan Huilin 
Published: August 2024

AbstractAqueous batteries are attractive due to their high safety and fast reaction kinetics, but the narrow electrochemical stability window of H2O limits their applications. It is a big challenge to broaden the electrochemical operation window of aqueous electrolytes while retaining fast reaction kinetics. Here, a new organic aqueous mixture electrolyte of manipulatable (3D) molecular microheterogeneity with H2O‐rich and H2O‐poor domains is demonstrated. H2O‐poor domains molecularly surround the reformed microclusters of H2O molecules through interfacial H‐bonds, which thus not only inhibit the long‐range transfer of H2O but also allow fast and consecutive Li+ transport. This new design enables low‐voltage anodes reversibly cycling with aqueous‐based electrolytes and high ionic conductivity of 4.5 mS cm−1. LiMn2O4||Li4Ti5O12 full cells demonstrate excellent cycling stability over 1000 cycles under various C rates and a low temperature of −20 °C. 1 Ah pouch cell delivers a high energy density of 79.3 Wh kg−1 and high Coulombic efficiency of 99.4% at 1 C over 200 cycles. This work provides new insights into the design of electrolytes based on the molecular microheterogeneity for rechargeable batteries.
Landscape of Subcutaneous Administration Strategies for Monoclonal Antibodies in Oncology
Authors: Jacquot Guillaume , Lopez Navarro Pedro , Grange Coralie , Boudali Lotfi , Harlepp Sébastien , Pivot Xavier , Detappe Alexandre 
Published: August 2024

AbstractIn recent decades, subcutaneous (SC) administration of monoclonal antibodies (mAbs) has emerged as a promising alternative to intravenous delivery in oncology, offering comparable therapeutic efficacy while addressing patient preferences. This perspective article provides an in‐depth analysis of the technological landscape surrounding SC mAb administration in oncology. It outlines various technologies under evaluation across developmental stages, spanning from preclinical investigations to the integration of established methodologies in clinical practice. Additionally, this perspective article explores emerging trends and prospective trajectories, shedding light on the evolving landscape of SC mAb administration. Furthermore, it emphasizes key checkpoints related to quality attributes essential for optimizing mAb delivery via the SC route. This review serves as a valuable resource for researchers, clinicians, and healthcare policymakers, offering insights into the advancement of SC mAb administration in oncology and its implications for patient care.
Scanning Probe Microscopy of Halide Perovskite Solar Cells
Authors: Lee Minwoo , Wang Lei , Zhang Dawei , Li Jiangyu , Kim Jincheol , Yun Jae Sung , Seidel Jan 
Published: August 2024

AbstractScanning probe microscopy (SPM) has enabled significant new insights into the nanoscale and microscale properties of solar cell materials and underlying working principles of photovoltaic and optoelectronic technology. Various SPM modes, including atomic force microscopy, Kelvin probe force microscopy, conductive atomic force microscopy, piezoresponse force microscopy, and scanning near‐field optical microscopy, can be used for the investigation of electrical, optical and chemical properties of associated functional materials. A large body of work has improved the understanding of solar cell device processing and synthesis in close synergy with SPM investigations in recent years. This review provides an overview of SPM measurement capabilities and attainable insight with a focus on recently widely investigated halide perovskite materials.
Porous Polymeric Electrodes for Electrochemical Carbon Dioxide Capture
Authors: Guo Youhong , Massen‐Hane Michael , Endy Grace , Hatton T. Alan 
Published: August 2024

AbstractCarbon capture is a promising technology to mitigate greenhouse gas emissions to achieve net carbon neutrality. Electro‐swing reactive adsorption has emerged as an attractive approach for sustainable decarbonization. However, current electrodes with limited gas transport present a major barrier that hinders their practical implementation. Herein, porous polymeric electrodes are developed to effectively enhance CO2 transport without the need for additional gas diffusion conduits. Such all‐in‐one porous electrodes also enable more accessible redox active sites (e.g., quinones) for CO2 sorption, leading to an increased materials utilization efficiency of ≈90%. A continuous flow‐through carbon capture and release operation with high Faradaic efficiency and excellent stability under practical working conditions is further demonstrated. Together with low cost and robust mechanical properties, the as‐developed porous polymeric electrodes highlight the potential to advance the future implementation of electrochemical separation technologies.
Photothermal Catalytic Reduction and Bone Tissue Engineering Towards a Three‐in‐One Therapy Strategy for Osteosarcoma
Authors: Lu Hengli , Li Zihua , Duan Zhengwei , Liao Yuxin , Liu Kaiyuan , Zhang Yiwei , Fan Lin , Xu Tianyang , Yang Dong , Wang Sen , Fu Yuesong , Xiang Huijing , Chen Yu , Li Guodong 
Published: August 2024

AbstractOsteosarcoma is one of the most dreadful bone neoplasms in young people, necessitating the development of innovative therapies that can effectively eliminate tumors while minimizing damage to limb function. An ideal therapeutic strategy should possess three essential capabilities: antitumor effects, tissue‐protective properties, and the ability to enhance osteogenesis. In this study, self‐assembled Ce‐substituted molybdenum blue (CMB) nanowheel crystals are synthesized and loaded onto 3D‐printed bioactive glass (CMB@BG) scaffolds to develop a unique three‐in‐one treatment approach for osteosarcoma. The CMB@BG scaffolds exhibit outstanding photothermally derived tumor ablation within the near‐infrared‐II window due to the surface plasmon resonance properties of the CMB nanowheel crystals. Furthermore, the photothermally synergistic catalytic effect of CMB promotes the rapid scavenging of reactive oxygen species caused by excessive heat, thereby suppressing inflammation and protecting surrounding tissues. The CMB@BG scaffolds possess pro‐proliferation and pro‐differentiation capabilities that efficiently accelerate bone regeneration within bone defects. Altogether, the CMB@BG scaffolds that combine highly efficient tumor ablation, tissue protection based on anti‐inflammatory mechanisms, and enhanced osteogenic ability are likely to be a point‐to‐point solution for the comprehensive therapeutic needs of osteosarcoma.
Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy
Authors: Akinnawo Christianah Aarinola , Dube Admire 
Published: August 2024

AbstractGlobally a significant burden of tuberculosis (TB) is faced, which is difficult to eradicate due to patients' non‐adherence, and drug‐resistant strains that are spreading at an alarming rate. Novel approaches are required to improve diagnosis and treatment. Metallic nanoparticles (MNPs) have demonstrated potential as sensor probes and in combination therapy, which combines MNPs with antimycobacterial drugs to develop new treatment and theranostic approaches. To strengthen the theoretical foundation toward the clinical application of TB nanomedicine, this review focuses on the properties and effectiveness of therapeutically relevant MNPs. It also elaborates on their antimycobacterial mechanisms. This review aims to analyze the body of literature on the topic, pinpoint important empirical findings, and identify knowledge gaps that can provide a basis for future research endeavors and translation of the technologies. Current data suggest that MNPs are potential systems for efficient diagnosis and treatment although additional pre‐clinical and clinical research is needed to bring these technologies to the clinic.
Graphene Field‐Effect Transistors for Sensing Ion‐Channel Coupled Receptors: Toward Biohybrid Nanoelectronics for Chemical Detection
Authors: Terral Océane , Audic Guillaume , Claudel Arnaud , Magnat Justine , Dupont Aurélie , Moreau Christophe J. , Delacour Cécile 
Published: August 2024

AbstractGraphene field effect transistors (G‐FETs) have appeared as suitable candidates for sensing charges and have thus attracted large interest for ion and chemical detections. In particular, their high sensitivity, chemical robustness, transparency, and bendability offer a unique combination for interfacing living and soft matters. Here demonstrated their ability to sense targeted biomolecules is demonstrated, by combining them with ion channel‐coupled receptors (ICCRs). These receptors are naturally or artificially expressed within living cell membranes to generate ion fluxes in the presence of chemicals of interest. Here, those biosensors are successfully combined with a G‐FET array which converts the bio‐activation of the ICCRs into readable electronic signals. This hybrid bioelectronic device leverages the advantages of the biological receptor and the graphene field effect transistor enabling the selective detection of biomolecules, which is a current shortcoming of electronic sensors. Additionally, the G‐FET allows for discrimination of the polarity of the ion fluxes which otherwise remains hidden from conventional electrophysiological recordings. The multisite recording ability offered by the G‐FET array raises numerous possibilities for multiscale sensing and high throughput screening of cellular solutions or analytes, which is of both fundamental and applied interest in health and environment monitoring.
Monitoring the sonochemical field: A critical review of chemical dosimetry methods
Authors: Dehane Aissa , Merouani Slimane 
Published: August 2024

AbstractSonochemistry is a fascinating field that has drawn considerable interest from researchers across different disciplines. One of the key challenges in this field is the accurate characterization of the sonochemical field, which is crucial for understanding the underlying mechanisms and optimizing the process. To address this challenge, researchers have developed various monitoring methods that allow them to measure key parameters such as the intensity, frequency, and distribution of acoustic waves in the sonoreactor. In this review, we focus on the chemical dosimetry techniques that are commonly used for sonochemical monitoring. These techniques have been extensively studied in the literature and are known for their reliability and accuracy. However, as we will see, the performance of these techniques can vary depending on the chemical nature of the probing species and the experimental conditions, highlighting the need for a careful selection and calibration of the monitoring method. We begin by discussing the principles of chemical dosimetry in sonochemistry and how these methods can be used to measure key sono‐acoustic parameters. We then provide a detailed analysis of the various dosimetry techniques, including their advantages, limitations, and applicability under different operating conditions. In summary, our review serves as a valuable resource for researchers seeking to optimize their sonochemical experiments and contribute to the advancement of this fascinating field.