bluuebunny/crossref_metadata_2025_split huggingface dataset:
After MacIntyre
Authors: Humbert David 
Published: April 2014

AbstractIn his influential book After Virtue, Alasdair MacIntyre identifies Kierkegaard's view of ethics with that of Kant. Both Kant and Kierkegaard, according to MacIntyre, accept the modern paradigm of moral activity for which freedom of the will is the ultimate basis. Ronald M. Green, in Kierkegaard and Kant: The Hidden Debt, accepts and deepens this alignment between the two thinkers. Green argues that Kierkegaard deliberately obscured his debt to Kant by a systematic “misattribution” of his ideas to other thinkers, and to classical philosophy in particular. This essay argues that MacIntyre and Green are mistaken in identifying Kierkegaard with the Kantian tradition of moral autonomy and that they overlook his debt to the classical conception of virtue. In casting Kierkegaard in the role of the quintessential exponent of a modern conception of freedom, they have perhaps overlooked one of the greatest critics of moral autonomy who has ever lived.
On Comparative Religious Ethics as a Field of Study
Authors: Bucar Elizabeth M. , Stalnaker Aaron 
Published: April 2014

AbstractThis essay is a critical engagement with recent assessments of comparative religious ethics by John Kelsay and Jung Lee. Contra Kelsay's proposal to return to a neo‐Weberian sociology of religious norm elaboration and justification, the authors argue that comparative religious ethics is and should be practiced as a field of study in active conversation with other fields that consider human flourishing, employing a variety of methods that have their roots in multiple disciplines. Cross‐pollination from a variety of disciplines is a strength of comparative ethics, which has enlivened recent and ongoing research on ethics, not a problem to be resolved by convergence on a single, distinctively comparative project. The authors also argue in response to Lee and Kelsay that while individual comparative studies of virtue and personal formation can be flawed in various ways, this line of research has been productive and at times very compelling. Moreover, attention to comparative virtue ethics shows how scholarship on some ethical topics necessitates drawing on a variety of perspectives and disciplinary backgrounds, a conclusion relevant to all work in religious ethics today.
Event‐related potentials reveal linguistic suppression effect but not enhancement effect on categorical perception of color
Authors: Lu Aitao , Yang Ling , Yu Yanping , Zhang Meichao , Shao Yulan , Zhang Honghong 
Published: April 2014

The present study used the event‐related potential technique to investigate the nature of linguistic effect on color perception. Four types of stimuli based on hue differences between a target color and a preceding color were used: zero hue step within‐category color (0‐WC); one hue step within‐category color (1‐WC); one hue step between‐category color (1‐BC); and two hue step between‐category color (2‐BC). The ERP results showed no significant effect of stimulus type in the 100‐200 ms time window. However, in the 200–350 ms time window, ERP responses to 1‐WC target color overlapped with that to 0‐WC target color for right visual field (RVF) but not left visual field (LVF) presentation. For the 1‐BC condition, ERP amplitudes were comparable in the two visual fields, both being significantly different from the 0‐WC condition. The 2‐BC condition showed the same pattern as the 1‐BC condition. These results suggest that the categorical perception of color in RVF is due to linguistic suppression on within‐category color discrimination but not between‐category color enhancement, and that the effect is independent of early perceptual processes.
Marginal and Conditional Distribution Estimation from Double‐sampled Semi‐competing Risks Data
Authors: Yu Menggang , Yiannoutsos Constantin T. 
Published: April 2014

AbstractInformative dropout is a vexing problem for any biomedical study. Most existing statistical methods attempt to correct estimation bias related to this phenomenon by specifying unverifiable assumptions about the dropout mechanism. We consider a cohort study in Africa that uses an outreach programme to ascertain the vital status for dropout subjects. These data can be used to identify a number of relevant distributions. However, as only a subset of dropout subjects were followed, vital status ascertainment was incomplete. We use semi‐competing risk methods as our analysis framework to address this specific case where the terminal event is incompletely ascertained and consider various procedures for estimating the marginal distribution of dropout and the marginal and conditional distributions of survival. We also consider model selection and estimation efficiency in our setting. Performance of the proposed methods is demonstrated via simulations, asymptotic study and analysis of the study data.
Impact of prophylactic platelet transfusions on bleeding events in patients with hematologic malignancies: a subgroup analysis of a randomized trial (CME)
Authors: Stanworth Simon J. , Estcourt Lise J. , Llewelyn Charlotte A. , Murphy Michael F. , Wood Erica M. ,   TOPPS Study Investigators
Published: April 2014

BackgroundA recent randomized trial compared a policy of no prophylaxis with a policy of prophylactic platelet (PLT) transfusions at counts of fewer than 10 × 109/L in patients with hematologic malignancies. The results suggested the effectiveness of prophylactic PLT transfusions may vary according to patient diagnosis and treatment plan.Study Design and MethodsThis article presents full subgroup analyses and compares treatment effects between autologous hematopoietic stem cell transplantation (autoHSCT; n = 421) and chemotherapy/allogeneic HSCT (chemo/alloHSCT; n = 179) patients.ResultsPrespecified subgroup analysis found that the reduction in proportion of patients experiencing WHO Grade 2 to 4 bleeds (main trial outcome) seen in the prophylaxis arm was of greater magnitude in chemo/alloHSCT than autoHSCT patients (interaction p = 0.04). Analysis of secondary outcomes showed a shorter time to first bleeding episode with no prophylaxis in the chemo/alloHSCT group (hazard ratio, 1.84; 95% confidence interval CI, 1.21‐2.79; p = 0.004) compared to the autoHSCT group (hazard ratio, 1.12; 95% CI, 0.85‐1.48; p = 0.4; interaction p = 0.08). The increased number of days with Grade 2 to 4 bleeds with a no‐prophylaxis policy was similar in chemo/alloHSCT (rate ratio, 1.89; 95% CI, 1.10‐3.26) and in autoHSCT patients (rate ratio, 1.43; 95% CI, 1.04‐1.97). Both subgroups showed significant reductions in PLT transfusions with a no‐prophylaxis strategy.ConclusionThere is evidence that the effectiveness of prophylactic PLT transfusions may differ between subgroups, with chemo/alloHSCT patients receiving prophylactic PLT transfusions appearing to show a greater reduction in bleeding outcomes compared to patients following a no‐prophylaxis policy.
Antimicrobial activity in cord blood units: occurrence and levels of antibiotics
Authors: Cayer Marie‐Pierre , Girard Mélissa , Fournier Diane , Delage Gilles , Thibault Louis 
Published: April 2014

BackgroundAntibiotic prophylaxis treatment at delivery is highly recommended for reducing the risk of infection for mothers positive for group B streptococcus. It is therefore expected that some cord blood (CB) products will contain residual antibiotics. This study aimed to determine the incidence and level of β‐lactam antibiotics in CB products.Study Design and MethodsThe antimicrobial activity of 60 CB plasma by‐products was evaluated using disk diffusion assays on 10 bacteria species. Plasma samples showing antimicrobial activity were either treated with β‐lactamase enzyme to inhibit β‐lactam antibiotics or heated to 56°C for 30 minutes to inhibit complement proteins. β‐Lactam antibiotic concentrations were determined by comparison with a standard curve obtained with known concentrations of antibiotics.ResultsAntimicrobial activity against mostly Gram‐positive microorganisms was observed in 33% of CB units. The β‐lactamase enzyme abolished the antimicrobial activity in the majority of these CB products. Up to 5 μg/mL penicillin and 14 μg/mL ampicillin were measured in these products.ConclusionApproximately one‐third of CB products contain significant amounts of plasma with residual antibiotics, which can affect the survival and growth of bacterial contaminants when performing the sterility test and potentially lead to false‐negative results. Additional work is required to better understand whether residual antibiotics in CB affect penicillin‐allergic patients.
An observational study: associations between nurse-reported hospital characteristics and estimated 30-day survival probabilities
Authors: Tvedt Christine , Sjetne Ingeborg Strømseng , Helgeland Jon , Bukholm Geir 
Published: April 2014

BackgroundThere is a growing body of evidence for associations between the work environment and patient outcomes. A good work environment may maximise healthcare workers’ efforts to avoid failures and to facilitate quality care that is focused on patient safety. Several studies use nurse-reported quality measures, but it is uncertain whether these outcomes are correlated with clinical outcomes. The aim of this study was to determine the correlations between hospital-aggregated, nurse-assessed quality and safety, and estimated probabilities for 30-day survival in and out of hospital.MethodsIn a multicentre study involving almost all Norwegian hospitals with more than 85 beds (sample size=30, information about nurses’ perceptions of organisational characteristics were collected. Subscales from this survey were used to describe properties of the organisations: quality system, patient safety management, nurse–physician relationship, staffing adequacy, quality of nursing and patient safety. The average scores for these organisational characteristics were aggregated to hospital level, and merged with estimated probabilities for 30-day survival in and out of hospital (survival probabilities) from a national database. In this observational, ecological study, the relationships between the organisational characteristics (independent variables) and clinical outcomes (survival probabilities) were examined.ResultsSurvival probabilities were correlated with nurse-assessed quality of nursing. Furthermore, the subjective perception of staffing adequacy was correlated with overall survival.ConclusionsThis study showed that perceived staffing adequacy and nurses’ assessments of quality of nursing were correlated with survival probabilities. It is suggested that the way nurses characterise the microsystems they belong to, also reflects the general performance of hospitals.
Dietary pattern trajectories during 15 years of follow-up and HbA1c, insulin resistance and diabetes prevalence among Chinese adults
Authors: Batis Carolina , Mendez Michelle A , Sotres-Alvarez Daniela , Gordon-Larsen Penny , Popkin Barry 
Published: April 2014

BackgroundMost research on dietary patterns and health outcomes does not include longitudinal exposure data. We used an innovative technique to capture dietary pattern trajectories and their association with haemoglobin A1c (HbA1c), homeostasis model of insulin resistance (HOMA-IR) and prevalence of newly diagnosed diabetes.MethodsWe included 4096 adults with 3–6 waves of diet data (1991–2006) and biomarkers measured in 2009 from the China Health and Nutrition Survey. Diet was assessed with three 24-h recalls and a household food inventory. We used a dietary pattern previously identified with reduced rank regression that positively predicted diabetes in 2006 (high in wheat products and soy milk and low in rice, legumes, poultry, eggs and fish). We estimated a score for this dietary pattern for each subject at each wave. Using latent class trajectory analysis, we grouped subjects with similar dietary pattern score trajectories over time into five classes.ResultsThree trajectory classes were stable over time, and in two classes the diet became unhealthier over time (upward trend in dietary pattern score). Among two classes with similar scores in 2006, the one with the lower (healthier) initial score had an HbA1c 1.64% lower (−1.64 (95% CI −3.17 to −0.11)) and non-significantly a HOMA-IR 6.47% lower (−6.47 (−17.37 to 4.42)) and lower odds of diabetes (0.86 (0.44 to 1.67)).ConclusionsOur findings suggest that dietary pattern trajectories with healthier scores longitudinally had a lower HbA1c compared with those with unhealthier scores, even when the trajectories had similar scores in the end point.
A novel model of large vessel ischemic stroke in rabbits: microcatheter occlusion of the posterior cerebral artery
Authors: English Joey D , Hetts Steven W , El-Ali Alex , Kolli Pallav , Do Loi , Wilson Mark W , Saeed Maythem 
Published: April 2014

Background and purposeThe rabbit small clot embolic model for large vessel occlusion (LVO) is well established, yet has limitations. Blind introduction of autologous thrombus often fails to completely occlude a target vessel and, when successful, the precise timing of occlusion and revascularization is difficult to control. Studies of cellular biology and neuroimaging of acute reversible cerebral ischemia (ie, penumbral tissue) would benefit from a rabbit model in which LVO can be reliably induced, easily confirmed, and in which the time of occlusion and revascularization can be precisely controlled.MethodsTransfemoral 1.5 F microcatheterization of the posterior cerebral artery (PCA) was performed in anesthetized rabbits (n=7) using fluoroscopic guidance. LVO with the wedged microcatheter was maintained for 30–210 min followed by reperfusion. Diffusion-weighted and T2 fluid-attenuated inversion recovery (FLAIR) MRI was performed 3 h after catheter removal on a 3 T scanner. Post-mortem histopathologic analysis of brain tissue was performed using triphenyltetrazolium chloride (TTC).ResultsPlacing of the 1.5 F microcatheter tip in the PCA was successful in all seven animals. Infarct size on matched diffusion-weighted and TTC sections was strongly correlated (r2=0.86). Transient PCA occlusion of 30–60 min resulted in infarction of the ipsilateral hippocampus and thalamus, sparing the cortex, while more prolonged occlusion (180–210 min) resulted in cortical infarction as well.ConclusionsImage-guided microcatheter induction of PCA occlusion in rabbits can consistently produce time-dependent infarction of cortical and subcortical structures that is reliably detected by diffusion-weighted MRI, and thus may be a useful model for therapeutic studies in acute ischemic stroke.
Unprotected carotid artery stenting in symptomatic elderly patients: a single-center experience
Authors: Jimenez-Gomez Elvira , Cano Sánchez Antonio , Oteros Fernández Rafael , Valenzuela Alvarado Saray , Bravo-Rodriguez Francisco , Delgado Acosta Fernando 
Published: April 2014

Background and purposeSurgery is known to have fewer adverse events in patients aged >75 years with carotid stenosis, but some are not candidates due to comorbidity. Stenting using protection devices is the most accepted endovascular technique. Our aim is to show the safety and efficacy of carotid stenting without any protection device in these patients.Material and methodsAll patients older than 75 years with carotid stenosis treated in our center between January 2002 and December 2012 were included in this prospective study. All were treated by carotid stenting without protection devices. Angiographic results, neurologic complications and Doppler ultrasound were collected during the procedure and within 30 days.Results49 patients were included (mean age 78.2 years, range 75–86). The average degree of stenosis was 88.2%. During the procedure there were two cases of transient ischemic attack and one intraparenchymal hemorrhage. At 30 days there was a non-disabling stroke. The combined rate of disabling stroke plus myocardial infarction plus death was 6% at 30 days and the rate of any stroke was 4% during the procedure and 2% at 30 days.ConclusionsEndovascular treatment of carotid stenosis without protection devices in symptomatic patients aged >75 years is an alternative to endovascular treatment with protection devices. Complications and mortality rates are similar to studies that used protection devices in lower risk patients.
Extracranial carotid artery stenting followed by intracranial stent-based thrombectomy for acute tandem occlusive disease
Authors: Cohen José E , Gomori J Moshe , Rajz Gustavo , Itshayek Eyal , Eichel Roni , Leker Ronen R 
Published: April 2014

ObjectiveAcute tandem occlusions of the extracranial internal carotid artery (ICA) and a major intracranial artery respond poorly to intravenous tissue plasminogen activator (tPA) and present an endovascular challenge. We describe our experience with emergency stent-assisted ICA angioplasty and intracranial stent-based thrombectomy of tandem occlusions.MethodsProcedures were performed from March 2010 to December 2013. National Institutes of Health Stroke Score (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS), occlusion sites, collateral supply, procedural details, and outcomes were retrospectively reviewed with IRB waiver of informed consent.Results24 patients, mean age 66 years, mean admission NIHSS 20.4, and mean ASPECTS 9 were included. Occlusion sites were proximal ICA–middle cerebral artery (MCA) trunk in 17 patients, proximal ICA–ICA terminus in six, and ICA–MCA–anterior cerebral artery in one. Stent-assisted cervical ICA recanalization was achieved in all patients, with unprotected pre-angioplasty in 24/24, unprotected stenting in 16/24 (67%), and protected stenting in 8/24 (33%), followed by stent-thrombectomy in 25 intracranial occlusions. There was complete recanalization/complete perfusion in 19/24 (79%), complete recanalization/partial perfusion in 3/24 (13%), and partial recanalization/partial perfusion in 2/24 (8%) with no procedural morbidity/mortality. Mean time to therapy was 3.8 h (range 2–5.5) and mean time to recanalization was 51 min (range 38–69). At 3-month follow-up, among 17/22 surviving patients (77%), 13/17 (76%) were modified Rankin Scale (mRS) 0–2 and 3/17 (18%) were mRS 3.ConclusionsIn acute tandem ICA–MCA/distal ICA occlusions, extracranial stenting followed by intracranial stent-based thrombectomy appears feasible, effective, and safe. Further evaluation of this treatment strategy is warranted.
Re-allocation of two south Chinese species of Argyrodiaptomus Brehm, 1933 to Sinodiaptomus Kiefer, 1932, and biogeography of the genus Sinodiaptomus (Copepoda, Calanoida, Diaptomidae)
Authors: Ming Li Hui , Han Bo Ping , Fei Guo Fei , Dumont Henri J. 
Published: April 2014

In 1964 and 1965, Shen & Tai described two species of calanoids, which they classified in the South American genus Argyrodiaptomus. We examined new material from the terra typica, South China, and show that both species belong in the Asian genus Sinodiaptomus. A biogeographic anomaly is thus corrected. Moreover, the two appear to be sister species and males are morphologically well separable. No intermediate morphotypes have so far been detected. S. cavernicolax (Shen & Tai, 1965), known only from the type locality, was claimed to be cavernicolous, but shows no stygobitic adaptations, and has eyes. It may have been pushed back into the cave environment by its congener S. ferus (Shen & Tai, 1964) with which it coexists in the same lake system.
So far, four species of Sinodiaptomus have been found in China: the two mentioned above, i.e., S. cavernicolax only in Longyan Cave of Zhaoqing City, and S. ferus at about five locations, but its range is limited to a small part of Guangdong Province. All five other species of Sinodiaptomus, among which the other two that occur (also) in China, also occupy small to very small ranges, with the type species (S. chaffanjoni Richard, 1897) only living in North China, and S. indicus Kiefer, 1936 and S. mahanandiensis Reddy & Radhakrishna, 1980 confined to South India (Reddy & Radhakrishna, 1980). S. valkanovi Kiefer, 1938 from Japan is invasive (Ueda & Ohtsuka, 1998; Makino et al., 2010). S. sarsi Rylov, 1923, distributed in Japan, China, and most of Mongolia, is separated by a wide disjunction from a group of populations in Iran, the Caucasus, and East Anatolia. This western group of populations might be a separate species and deserves more study.
On the Strengthened Relationship between the East Asian Winter Monsoon and Arctic Oscillation: A Comparison of 1950–70 and 1983–2012
Authors: Li Fei , Wang Huijun , Gao Yongqi 
Published: April 2014

In this paper, the authors use NCEP reanalysis and 40-yr ECMWF Re-Analysis (ERA-40) data to document the strengthened relationship between the East Asian winter monsoon (EAWM) and winter Arctic Oscillation (AO) on the interannual time scale with a comparison of 1950–70 and 1983–2012. Their connection was statistically insignificant during 1950–70, whereas it was statistically significant during 1983–2012. The latter significant connection might be attributed to the East Asian jet stream (EAJS) upstream extension: the EAJS signal is relatively confined to the western North Pacific before the 1970s, whereas it extends westward toward East Asia after the 1980s. This upstream extension leads to the rearrangement of eastward-propagating Rossby waves with a much wider horizontal structure, thereby bonding the EAWM and the AO. Furthermore, the authors present observational evidence and model simulations demonstrating that the reduction of autumn Arctic sea ice cover (ASIC) is responsible for the strengthened EAWM–AO relationship after the 1980s by producing the EAJS upstream extension. After the 1980s, a strong anticyclonic anomaly over the polar ocean and anomalous easterly advection over northern Eurasia are generated by the near-surface heating over the Barents–Kara (B–K) Seas caused by the reduction of ASIC. This further induces cold anomalies over northern Eurasia, altering the meridional temperature gradient between the midlatitude and tropical region and consequently leading to westward penetration of the EAJS.
The Representation of Ocean Circulation and Variability in Thermodynamic Coordinates
Authors: Groeskamp Sjoerd , Zika Jan D. , McDougall Trevor J. , Sloyan Bernadette M. , Laliberté Frédéric 
Published: April 2014

Abstract
The ocean’s circulation is analyzed in Absolute Salinity SA and Conservative Temperature Θ coordinates. It is separated into 1) an advective component related to geographical displacements in the direction normal to SA and Θ isosurfaces and 2) into a local component, related to local changes in SA–Θ values, without a geographical displacement. In this decomposition, the sum of the advective and local components of the circulation is equivalent to the material derivative of SA and Θ. The sum is directly related to sources and sinks of salt and heat. The advective component is represented by the advective thermohaline streamfunction . After removing a trend, the local component can be represented by the local thermohaline streamfunction . Here, can be diagnosed using a monthly averaged time series of SA and Θ from an observational dataset. In addition, and are determined from a coupled climate model. The diathermohaline streamfunction is the sum of and and represents the nondivergent diathermohaline circulation in SA–Θ coordinates. The diathermohaline trend, resulting from the trend in the local changes of SA and Θ, quantifies the redistribution of the ocean’s volume in SA–Θ coordinates over time. It is argued that the diathermohaline streamfunction provides a powerful tool for the analysis of and comparison among ocean models and observation-based gridded climatologies.