bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin Tags as Markers of Diabetes Mellitus: An Epidemiological Study in India
Authors: Thappa Devinder Mohan 
Published: April 2015

AbstractTo ascertain whether skin tags (ST) are associated with a higher risk for diabetes mellitus (DM), 35 patients with ST were screened out of 5000 consecutive patients visiting our dermatology clinic. The study group ranged in age from 35 to 73 years, with a mean of 52.03. Twenty‐six of the patients were men, and nine, women. The risk of getting ST was found to increase with age, but this risk decreased after the fifth decade. The neck was invariably involved, followed by the eyelids, axillae and groin. Of the cases, 62.8% (22 patients) had DM. Four new cases of DM were found among this group. All the diabetic patients in this study population had noninsulin dependent DM. The frequency of DM in ST patients was found to increase with age, however, it was statistically insignificant. No correlation was found between localisation, size, color, or number of ST and the presence of DM. The frequency with which ST had been found to co‐exist with DM in this population is significant, and ST may serve as a marker for DM.
Malignant Schwannoma Arising in Patients with Von Recklinghausen's Disease: Report of Two Cases and the Comparison of Mast Cells between Benign and Malignant Portions
Authors: Demitsu Toshio , Murata Satoru , Kiyosawa Tomoharu , Yamada Tomoko , Sato Hisao , Hiraga Takeshi , Yamane Yasuhiro , Yaoita Hideo 
Published: April 2015

AbstractWe described two cases of malignant schwannoma arising in patients with von Recklinghausen's disease and examined the mast cells infiltrated into histologic sections. One of the two cases histologically revealed apparent mast cell infiltration in some areas of malignant schwannoma as well as in the benign neurofibroma. The malignant lesion demonstrated significantly increased percentages of degranulated mast cells over the benign lesion using FITC‐avidin staining. In an electron microscopic study, mast cells in the malignant lesion displayed empty granules, piecemeal degranulation, and canaliculi structures suggesting activation. These findings were not observed in the benign lesion. The other patient histologically showed no mast cells in the malignant lesion, although the benign neurofibroma in the patient disclosed numerous mast cells. The first patient had neither recurrence nor distant metastasis. On the other hand, the second patient without mast cells in the histology had multiple distant metastases.These findings raise questions about the role of mast cells in malignant schwannoma.
Successful Treatment of Vitiligo with a Sex Steroid‐Thyroid Hormone Mixture
Authors: Muto Masahiko , Furumoto Hiroko , Ohmura Akiko , Asagami Chidori 
Published: April 2015

AbstractFour patients with generalized vitiligo were successfully treated by oral administration of a sex steroid‐thyroid hormone (Metharmon‐F®, 2 tablets daily). Histopathologically, the repigmented skin showed increased numbers of melanocytes and melanin granules in the keratinocytes.
A Case of Drug Eruption Caused by the Crude Drug Boi® (Sinomenium Stem/Sinomeni Caulis et Rhizoma)
Authors: Okuda Tomoki , Umezawa Yoshinori , Ichikawa Makiko , Hirata Masako , Oh‐i Tsunao , Koga Michiyuki 
Published: April 2015

AbstractWe report a case of drug eruption caused by the crude drug Boi®. A 41‐year‐old female patient had been diagnosed with chronic rheumatoid arthritis in the department of internal medicine. After ingestion of a decoction of the crude drug Boi® for the alleviation of arthralgia, a slight fever developed, which was followed by systemic edematous erythema with itching. HPLC showed that the main components of the crude drug Boi® are sinomenine and magnoflorine. The results of patch tests were negative for all oral drugs that the patient had been taking. Oral ingestion tests showed that the patient showed positive reactions to the as‐is Boi® boiling‐water decoction and 1/10‐volume sinomenine. Based on this, the drug eruption was judged to be caused by sinomenine. It is considered the first time that the causative component of a drug eruption was confirmed by oral ingestion tests with components of a crude drug of Kampo medicine (Sino‐Japanese traditional medicine).
The Epidemiology of Non‐Melanoma Skin Cancer: Who, Why and What Can We Do about It
Authors: Marks Robin 
Published: April 2015

AbstractNon‐melanoma skin cancer (NMSC) comprised of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common cancers in humans in many countries. Sunlight plays a major part in the development of these tumours which appear predominantly on areas of the most frequently exposed skin.The site distribution for BCC and SCC is not the same, with SCC being most common on the sites of very heavy exposure and BCC becoming more common on areas of only moderate exposure, e.g. upper trunk in men and women and lower leg in women.Incidence rates of NMSC, where they are being recorded, show rises over time. Mortality rates, on the other hand, have been dropping most of this century until they have been levelling out recently. The case fatality rate due to SCC appears to be between 1–2%. The malignant transformation rate of actinic keratoses to SCC appears to be very low.Studies on similar populations at different latitudes allow estimates to be made of increases which might occur with increasing exposure to ultraviolet radiation (UVR) over a life time. These have been used to estimate the possible increases in NMSC due to stratospheric ozone depletion.Finally, recent studies on the reduction of existing actinic keratoses and prevention of new ones with regular use of sunscreen augurs well for prevention of NMSC in the future.
Alopecia Areata in Korea (1982–1994)
Authors: Ro Byung In 
Published: April 2015

AbstractI clinically studied 905 patients with alopecia areata (AA) who visited the Department of Dermatology, College of Medicine, Chung Ang University, from January of 1982 to February of 1994. The purpose of the study was to evaluate the clinical manifestations and compare the effects of treatment with intralesional injection of triamcinolone acetonide suspension and immunotherapy with dinitrochlorobenzene (DNCB) or diphenylcyclopropenone (DPCP). The results were as follows: 1) The incidence of AA among all out‐patients (59,970) was 1.5% (905 cases), and the ratio of males to females was 1.3:1 (512:393). 2) The age distribution showed high incidences in the third (41.8%) and fourth decades (20.0%). 3) The family history was contributory in 104 cases (11.5%). 4) The relapse rate was 17.5% (158 cases). 5) Almost half of the patients had a solitary lesion (408 cases, 46.7%). 6) The most common site of predilection was the occipital region of the scalp in both male and female patients. 7) Associated diseases were seborrheic dermatitis, atopic dermatitis, hepatitis, hypertension, open heart surgery, thyroid disease, pulmonary disease, and vitiligo in order of frequency. 8) The effect of treatment on the patients who had bald patches less than 50 cm2 was not significantly statistically different between intralesional injection of triamcinolone acetonide and immunotherapy with DNCB or DPCP. 9) In cases with bald areas more than 50 cm2, including alopecia totalis and universalis, DNCB or DPCP immunotherapy showed better therapeutic effects than did intralesional injection of triamcinolone acetonide.
Regulatory Effects of Gamma‐Interferon on IL‐6 and IL‐8 Secretion by Cultured Human Keratinocytes and Dermal Fibroblasts
Authors: Maruyama Kohji , Zhang Jian‐Zhong , Nihei Yoshimichi , Ono Ichiro , Kaneko Fumio 
Published: April 2015

AbstractGamma‐interferon (IFN‐γ) is produced by T cells and plays an important role in immunological and inflammatory processes. To determine the effects of IFN‐γ on interleukin (IL)‐6 and IL‐8 secretion, normal human keratinocytes (NHKs), human squamous cell carcinoma cell line (HSC‐1) cells, and human dermal fibroblasts (HDFs) were incubated with 100 U/ml of recombinant (r) IFN‐γ in the presence of various stimulants. HSC‐1 cells and HDFs spontaneously secreted both IL‐6 and IL‐8 into the culture medium. NHKs secreted detectable levels of IL‐8, but not of IL‐6, and IL‐8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12‐myristate 13‐acetate (PMA). rIFN‐γ inhibited IL‐8 secretion in both HSC‐1 cells and PMA‐stimulated NHKs. On the other hand, it enhanced IL‐1α‐ and TNFα‐induced IL‐8 secretion in NHKs. In HDFs, rIFN‐γ inhibited IL‐8 secretion, but enhanced secretion of IL‐6, regardless of whether they were stimulated with IL‐1α or PMA. These results suggest that IFN‐γ has different regulatory effects on IL‐6 and IL‐8 secretion in NHKs and HDFs, depending on the stimulus.
Induction of the 72‐kD Heat Shock Protein in Human Skin Melanoma and Squamous Cell Carcinoma Cell Lines
Authors: Muramatsu Tsutomu , Kobayashi Nobuhiko , Tada Hideyuki , Hatoko Mitsuo , Shirai Toshihiko 
Published: April 2015

AbstractHeat shock proteins (HSPs) or stress proteins comprise a characteristic group of proteins synthesized in cells exposed to heat or other environmental stimuli. Of the many HSPs, the 72‐kD heat shock protein (HSP72) is the most stress‐inducible one. In the present study, we examined the effects of heat, chemicals (azetidine and sodium arsenite), ultraviolet (UV) light, and γ‐ray irradiation on the induction of HSP72 in cultured human skin melanoma cell lines (P‐39 and G‐361), a human skin squamous cell carcinoma cell line (HSC‐1), and an SV40‐transformed human lung fibroblast cell line (WI38VA13) as a control. In these cell lines, heat treatment induced HSP72 more rapidly and intensely than did chemical exposure. Compared with the SCC cell line, the two melanoma cell lines produced less HSP72 with heat treatment. UVC irradiation (20 J/m2) induced HSP72 only in the WI38VA13 cells. After γ‐ray irradiation, no HSP72 induction was detected in any of the cell lines examined. These observations suggest that, in cultured cells, inducibility of HSP72 depends not only on the inducer but also on the origin of each cell line.
Image Analysis of Nailfold Capillaries in Patients with Undifferentiated Connective Tissue Syndromes
Authors: Ohtsuka Tsutomu , Yamakage Akio , Tamura Taeko 
Published: April 2015

AbstractSeveral studies have reported patients that show nailfold capillary abnormality without fulfilling any of the criteria for rheumatic diseases. Our objective was to define how many patients with undifferentiated connective tissue syndrome (UCTS) have nailfold capillary abnormalities and to determine the correlation between capillary abnormality and clinical findings. We analyzed videograph images of nailfold capillaries in 75 patients with UCTS, comparing them with 22 normal controls (NL) and 55 patients with systemic sclerosis (SS), using standardized canonical discriminant analysis. Sixty patients with UCTS showed the SS type pattern and 15, the NL type pattern. The SS type pattern in patients with UCTS significantly correlated with Raynaud's phenomenon, telangiectasia, and anti‐nuclear antibody. The UCTS patients with nailfold capillary abnormalities correlated with symptoms of SS have a possibility of progressing to SS. The follow up study of these patients will show whether progression to SS occurs.
A Case of Pretibial Myxedema Associated with Graves' Disease: An Immunohistochemical Study of Serum‐derived Hyaluronan‐associated Protein
Authors: Shishido Mari , Kuroda Kei , Tsukifuji Reiko , Fujita Masaru , Shinkai Hiroshi 
Published: April 2015

AbstractThe myxomatous materials in cutis from a patient with pretibial myxedema (PTM) with Graves' disease were found to be mainly hyaluronic acid (HA), which had accumulated extensively in the upper dermis. Fibroblasts were increased in number in the mid to lower dermis. To clarify the mechanism of the deposition of HA in the dermis, we employed an antibody against serum‐derived hyaluronan‐associated protein (SHAP). This immunohistochemical study disclosed that the greater part of the fibroblasts in the mid to lower dermis stained positively, while the fibroblasts surrounded by fairly large amounts of HA in the upper dermis stained faintly or not at all. From these results, we suspect that the accumulation of HA progresses from the upper to the low dermis and that the interaction of fibroblasts and SHAP leads to development of the physiophathological cutaneous changes seen in our case.
A Case of Subacute Necrotizing Fasciitis
Authors: Imamura Yuzo , Kudo Yoshiko , Ishii Yoshiteru , Shibuya Hiromi , Takayasu Susumu 
Published: April 2015

AbstractWe report a 48‐year‐old woman who developed necrotizing groin fasciitis with insidious onset. Before she visited us, she had been unsuccessfully treated with several kinds of antibiotics by other doctors for one month, because of a small ulcer covered by blackish necrotic tissue. She was referred to us because of high fever, an ulcer on the left labium majus, and a cellulitis‐like lesion with severe pain on the lower abdomen. Methicillin‐resistant Staphylococcus aureus (MRSA), Streptococcus intermedius, and Bacteroides uniformis were isolated from the wound. After aggressive debridement on the eighth day after admission of the whole indurated area and the fascia of the underlying muscle, healthy granulation tissue covered the defect, and the wound was finally closed with a skin graft. Long‐term administration of antibiotics along with insufficient and delayed surgical treatment were considered to have caused the full development of this disease.
Granulomatous Pigmented Purpuric Dermatosis
Authors: Saito Ryuzo , Matsuoka Yoshitaka 
Published: April 2015

AbstractWe report two cases of brown pigmentation accompanied by hemorrhagic papules. A 61‐year‐old woman and a 53‐year‐old woman presented with brown pigmentation accompanied with hemorrhagic papules occurring bilaterally from the dorsal aspect of the feet to the lower legs. The clinical picture was of pigmented purpuric dermatosis, but histopathologically, they were hemorrhagic granulomatous inflammation of the upper dermis. As no systemic granulomatous lesions were observed, these cases were considered to be granulomatous pigmented purpuric dermatosis.
Successful Treatment of Molluscum Contagiosum in the Immunosuppressed Adult with Topical Injection of Streptococcal Preparation OK‐432
Authors: Inui Shigeki , Asada Hideo , Yoshikawa Kunihiko 
Published: April 2015

AbstractA 37‐year‐old Japanese woman received an anticancer drug for 5 years following resection of mammary cancer and then developed widespread mollusca contagiosa, which we considered to be caused by immunosuppression induced by the chemotherapy. Because OK‐432 (penicillin‐treated and heat‐treated lyophilized powder of a substrain of Streptococcus pyogenes A) was expected to be effective for immunosuppression, we tried its topical injection. The skin lesions disappeared almost completely within three months. OK‐432 therapy is considered hopeful for treating viral skin diseases, even in immunosuppressed patients.
Acquired Blaschko Dermatitis: Acquired Relapsing Self‐Healing Blaschko Dermatitis
Authors: Lee Ho Jung , Kang Won Hyung , Hann Seung Kyung 
Published: April 2015

AbstractAcquired Blaschko dermatitis is a rare disease with acquired unilateral relapsing inflammatory linear lesions along Blaschko's lines. Histopathology reveals spongiotic dermatitis. “Blaschkite de l'adulte” and “acquired relapsing self‐healing Blaschko dermatitis” have been suggested as names for this condition. Our patient was a 27‐year‐old man with a 6 month history of repeated, unilateral, slightly pruritic, discrete and grouped erythematous papules and papulovesicles on the left side of the upper limbs and trunk along Blaschko's lines. Histologic examination showed subacute spongiotic dermatitis. The condition showed excellent improvement after treatment with systemic corticosteroid for 2 months.Only a few cases have been reported. We propose a new designation and describe a patient who represents the first reported case of acquired Blaschko dermatitis in Korea.
Two Cases of Intravascular Papillary Endothelial Hyperplasia Developing on the Sole
Authors: Kato Haruhisa 
Published: April 2015

AbstractTwo cases of intravascular papillary endothelial hyperplasia (IPEH) are described. Each patients was a 49‐year‐old Japanese woman with a tender eruption on the sole. Histologically, the lesions proved to be IPEH. One of them had the typical histological appearance of IPEH, and the other showed a venous thrombus associated with histological manifestations of organization and recanalization. Newly formed vascular channels were seen at the periphery of the thrombus. These findings favored the hypothesis that IPEH usually results from peculiar organization of a thrombus.
Detection of Autoantibody against 97‐kD Antigen by Immunoblot, but not by Indirect Immunofluorescence, in a Patient with Linear IgA Bullous Dermatosis
Authors: Ohno Haruhiko , Muramatsu Tsutomu , Shirai Toshihiko 
Published: April 2015

AbstractA case of linear IgA bullous dermatosis in an 85‐year‐old man is reported. Direct immunofluorescence (IF) of the lesional skin showed linear deposition of IgA and weak deposition of IgG at the basement membrane zone. Although no circulating autoantibody was detected by indirect IF, immunoblotting analysis using NaCl‐separated normal human epidermal extracts revealed a circulating IgA antibody which bound to the 97‐kD antigen.
Prurigo Nodularis Associated with Advanced Gastric Cancer: Report of a Case
Authors: Funaki Mikio , Ohno Tomoya , Dekio Satoshi , Jidoi Joji , Nakagawa Chikage , Kin Seikon , Tamura Katsuhiro 
Published: April 2015

AbstractIn a male Japanese patient, prurigo nodularis (PN) appeared in association with gastric cancer. The cutaneous pruriginous lesions dramatically improved soon after total gastrectomy without any treatment for the skin lesions. Peripheral eosinophilia seen before the operation also rapidly disappeared. These data suggest that some cytokines involved in gastric cancer might have played an important role in the development of PN in our patient.
Multiple Nodular Lesions Seen in a Patient with Neurocutaneous Melanosis
Authors: Sasaki Yuko , Kobayashi Seiichiro , Shimizu Hiroshi , Nishikawa Takeji 
Published: April 2015

AbstractNeurocutaneous melanosis is a rare congenital syndrome characterized by the presence of large or multiple congenital melanotic nevi and benign or malignant pigment cell tumors of the leptomeninges. A 2‐month‐old female infant was referred to our department with widespread pigmented nevi, numerous blackish‐brown, elevated, firm nodules, eye lesions, temporal bone defect, and generalized convulsion. The sizes of the nodules were from 0.5 to 3 cm; they were either white, black brown or red, and some of them were eroded and bleeding.Magnetic resonance imaging using gadolinium contrast (MRI‐Gd) demonstrated hydrocephalus, defect of the temporal bone, and T1‐short and T2‐long areas near the cerebrum and the thoracic vertebra (Th 4–5), suggesting the presence of melanosis in the central nervous system. Biopsy specimen of a firm, black nodule of a pigmented lesion on her shoulder revealed sheets of nevomelanocytes in the dermis with a few mitoses and large atypical cells that were positive for HMB‐45 and formaldehyde‐induced green specific fluorescence. Although this histological architecture is compatible with that of congenital nevi, occasional occurrence of atypical mitoses in the dermis may consitute an early stage of malignant melanoma. To make a definite diagnosis, however, long‐time follow‐up and repeated skin biopsy are considered necessary.
Lentiginous Melanocytic Hyperplasia Overlying Dermatofibroma
Authors: Toda Sunao , Heasley Diane D. , Carlson J. Andrew , Mihm Martin C. 
Published: April 2015

AbstractThere are occasional reports of proliferative epidermal changes overlying dermatofibromas. We report the first case to our knowledge of a dermatofibroma with overlying lentiginous melanocytic hyperplasia.
Activity of Eleven Kampo Formulations and Eight Kampo Crude Drugs against Propionibacterium acnes Isolated from Acne Patients: Retrospective Evaluation in 1990 and 1995
Authors: Higaki Shuichi , Nakamura Motokazu , Morohashi Masaaki , Hasegawa Yoshinori , Yamagishi Takayoshi 
Published: April 2015

AbstractWe reviewed the susceptibility of Propionibacterium acnes to eleven Kampo formulations and to eight Kampo crude drugs that had been studied by examining their minimum inhibitory concentrations (MIC) in 1990 and 1995. P. acnes strains were most sensitive to Oren‐gedoku‐to (OGT) among these Kampo formulations. Coptidis Rhizoma (CR) and Phellodendri Cortex (PC) inhibited the growth of P. acnes significantly among the eight Kampo crude drugs examined. The patterns of distribution of MIC of Kampo formulations and Kampo crude drugs to P. acnes in this study were almost the same as in our previous report in 1990. No significant increases in MIC of Kampo formulations and Kampo crude drugs to P. acnes were observed.We speculated that Kampo crude drugs such as CR and PC, were better than minocycline or erythromycin from the point of view of a progressive increase in MIC to P. acnes. CR and PC, which were each an ingredient of OGT, might contain some components with strong antibacterial activity to P. acnes.
Three Cases of Linear Lichen Planus Caused by Dental Metal Compounds
Authors: Sasaki Go , Yokozeki Hiroo , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractThree cases of linear lichen planus on the lower extremities unaccompanied by mucous lesions are described. Dental metal compounds were thought to be the precipitating factor in all cases. Skin lesions did not respond to topical steroid ointment or antihistaminies. Two cases showed a positive patch test reaction to gold (HAuCl4) and a positive lymphocyte stimulation test to gold compound (Gold sodium thiomalate). One case showed a positive patch test reaction to mercury (HgCl2), but a negative lymphocyte stimulation test. Suspected metal compounds were demonstrated in their dental materials. Removal of gold materials in one case gradually improved the lesions within 6 months with a transient erythematous swelling of the face shortly after removal of the metal. Both of these cases responded to oral disodium chromoglycate therapy. These results suggest that metal compound specific T cells might be responsible for the development of linear lichen planus.
Induction of the Low‐Molecular‐Weight Stress Protein HSP27 in Organ‐Cultured Normal Human Skin
Authors: Muramatsu Tsutomu , Hatoko Mitsuo , Tada Hideyuki , Kobayashi Nobuhiko , Shirai Toshihiko 
Published: April 2015

AbstractTo examine the inducibility of 27‐kD‐molecular‐weight heat shock protein (HSP27) in human skin, an indirect immunofluorescence (IF) study was performed on organ‐cultured normal human skin by using a monoclonal antibody specific for HSP27. After heat treatment at 45°C for 1 h, nuclear IF was observed in the epidermal cells. When the organ‐cultured skin explants were exposed to 10.0 μg/ml or 100.0 μg/ml 8‐methoxypsoralen (8‐MOP) for 1 h and then irradiated with UVA (320–400 nm), positive nuclear IF was also observed 6 h after UVA irradiation. Considering these results with the previous reports about HSP72, it appears that, in human skin, HSP27 as well as HSP72 plays an important role in resisting various environmental stresses.