bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal aspects of haemophilia
Authors: Economou Marina , Banov Laura , Ljung Rolf 
Published: June 2014

AbstractHaemophilia is an X‐linked recessive genetic disease of haemostasis. Women carriers may present with a bleeding tendency similar to milder forms of the disease. Haemophilic newborns present risk factors and patterns of bleeding that are challenging. Identification of carriers and genetic counselling before conception is considered optimal to help decide on available conception options and during pregnancy to help minimise bleeding risks for both carrier mother and affected baby. Preimplantation genetic diagnosis is attractive to many couples at risk of having a child with haemophilia and relevant technology is becoming more available although it has both practical and ethical limitations. Pregnancy in carriers should be managed by a multidisciplinary team in a comprehensive treatment centre. The optimal mode of delivery for carriers expecting a baby known to have or being at risk of haemophilia is an issue of great debate. The general consensus among authors is avoidance of instrumental delivery, foetal scalp electrodes and blood sampling in pregnancies at risk of carrying an affected foetus, as well as early recourse to Caesarean section as guided by obstetric indications. Intracranial haemorrhage, although infrequent, is one the most devastating types of bleeding in haemophilic newborns and can occur regardless of the mode of delivery or the severity of haemophilia. Early screening is proposed for all infants with severe or moderate haemophilia who have had traumatic delivery and/or have evidence of extracranial haemorrhage. Women with postpartum haemorrhage should have a bleeding work‐up.
Long‐term results of a phase II trial with frontline concurrent chemoradiotherapy followed by consolidation chemotherapy for localized nasal natural killer/T‐cell lymphoma
Authors: Tsai Hui‐Jen , Lin Sheng‐Fung , Chen Chu‐Chih , Chen Tsai‐Yun , Su Wu‐Chou , Hwang Wen‐Li , Lin Jin‐Ching , Chiou Tzeon‐Jye , Kao Weio‐Yau , Chiu Chang‐Fang , Chang Yi‐Fang , Chang Jeffrey S. , Chang Ming‐Chih , Su Ih‐Jen 
Published: June 2014

AbstractPurposeA phase II trial was conducted to evaluate the therapeutic efficacy and safety profiles of frontline concurrent chemoradiotherapy (CCRT) plus consolidation chemotherapy for patients with stage I/II nasal natural killer/T‐cell lymphoma (NKTCL).Patients and methodsPatients with newly diagnosed, measurable stage I/II nasal NKTCL were eligible. The CCRT included two cycles of the DEP regimen (dexamethasone, etoposide, and cisplatin) every 4 wk with concurrent 5040 cGy radiation in 28 fractions for 5 wk. Patients without disease progression after CCRT were subjected to two cycles of DVIP consisted of dexamethasone, etoposide, ifosphamide, mesna, and cisplatin every 4 wk. The primary endpoint was tumor response rate, and secondary endpoints were survival and toxicities. This phase II study has been registered in the ClinicalTrials.gov (NCT00292695).ResultsThirty‐three patients received CCRT, and 29 patients received two cycles of consolidation DVIP after CCRT. Among the 32 evaluable patients, 20 achieved complete response and 6 achieved partial response. The overall and complete response rate was 81% (95% CI, 68–95%) and 63% (95% CI, 46–79%), respectively. The 2‐yr and 5‐yr progression‐free survival rate for intention‐to‐treat population was 64% (95% CI, 47–80%) and 60% (95% CI, 39–73%), respectively; while the corresponding overall survival rate was 73% (95% CI, 57–88%) and 66% (95% CI, 50–83%), respectively. The most common treatment‐related grade 3/4 adverse event was leukopenia (85%).ConclusionFrontline CCRT plus consolidation chemotherapy is feasible and effective for treating localized nasal NKTCL.
From bedside to bench – reverse translational medicine. Scientific lessons from revertant mosaicism in ‘knockout’ humans
Authors: Recke Andreas , Ludwig Ralf J. 
Published: June 2014

AbstractWhile the transition from basic life science research to clinical applications is often much more cumbersome than promised, Gostyński et al. took the opposite approach and demonstrated how a scholarly, biology‐guided perspective on human skin disease can reveal basic principles of human biology. Hereditary blistering diseases represent not only a disastrous fate for affected patients, but also an opportunity for understanding human molecular physiology and pathophysiology. On the basis of their clinical expertise, Gostyński et al. have elegantly used differences between lesional and non‐lesional as a unique opportunity to dissect the role of structural skin proteins – namely type XVII collagen, laminin β3 and type VII collagen – in melanocyte biology, thus elucidating a new concept in melanocyte biology by transferring knowledge in reverse direction from bedside to bench.
Immunomodulatory effects of heat shock protein 90 inhibition on humoral immune responses
Authors: Tukaj Stefan , Tiburzy Benjamin , Manz Rudolf , de Castro Marques Andreia , Orosz Antal , Ludwig Ralf J. , Zillikens Detlef , Kasperkiewicz Michael 
Published: June 2014

AbstractHeat shock protein 90 (Hsp90) inhibition blocks T‐cell‐linked inflammatory disease pathways and exhibits therapeutic activity in autoimmune disease mouse models, including the blistering disease epidermolysis bullosa acquisita. Although we previously showed that preformed autoreactive plasma cells do not seem to be directly affected by anti‐Hsp90 treatment, immunomodulatory effects of Hsp90 inhibition on (auto‐)antibody responses are not yet fully understood. In this study, the Hsp90 blocker 17‐DMAG inhibited proliferation of activated total B cells and their IgG secretion in cultures of human peripheral B cells from healthy subjects, but IgG production was no longer affected when these activated B cells were allowed to differentiate prior to a deferred application of the inhibitor. 17‐DMAG treatment was associated with induction of nuclear and cytoplasmic heat shock factor 1 and Hsp70 in stimulated human B cells, respectively. Type VII collagen (epidermolysis bullosa acquisita)‐immunized mice early treated with 17‐DMAG had reduced total B cells in spleens, a relative increase in splenic regulatory B cell fractions, higher serum IL‐10 concentrations, and lower levels of circulating autoantibodies (paralleled by less pronounced disease induction) compared with vehicle‐treated immunized mice. Autoantibody production was blunted in isolated and autoantigen‐restimulated lymph node cells from immunized mice by either 17‐DMAG or purified autologous splenic regulatory B cells. Thus, in addition to the previously described T cell inhibitory effects of Hsp90 blockade, this treatment potently modulates humoral immune responses at the B cell level, further supporting the introduction of Hsp90 inhibitors into the clinical setting for treatment of autoantibody‐mediated disorders.
Efficacy and safety of cisplatin versus miriplatin in transcatheter arterial chemoembolization and transarterial infusion chemotherapy for hepatocellular carcinoma: A randomized controlled trial
Authors: Otsuji Kentarou , Takai Koji , Nishigaki Yoichi , Shimizu Shougo , Hayashi Hideki , Imai Kenji , Suzuki Yusuke , Hanai Tatsunori , Ideta Takayasu , Miyazaki Tsuneyuki , Tomita Eiichi , Shimizu Masahito , Moriwaki Hisataka 
Published: June 2014

AimTranscatheter arterial chemoembolization (TACE) and transarterial infusion chemotherapy (TAI) are the main therapeutic strategies for treatment of advanced hepatocellular carcinoma (HCC). We conducted a randomized controlled trial to compare the efficacy and safety of cisplatin and miriplatin in TACE and TAI.MethodsPatients with HCC of indication for TACE or TAI were randomly assigned to receive either cisplatin or miriplatin (49 patients per group) between April 2010 and May 2013. The primary end‐point was the therapeutic effect (TE) 3 months after initial treatment, and the secondary end‐point was overall survival.ResultsTE could be evaluated in 26 patients of the cisplatin group and 20 patients of the miriplatin group. In the cisplatin group, 11 (42.3%) and 15 (57.7%) patients were classified as showing TE3 + 4 and TE1 + 2, respectively, while in the miriplatin group, each number was nine (45.0%) and 11 (55.0%) (P = 0.8551). Furthermore, no significant difference in overall survival was found between two groups for all patients (P = 0.905) or those treated only with TAI (10 in the cisplatin group and eight in the miriplatin group; P = 0.695). TE3 + 4 group showed better overall survival than TE1 + 2 group (P = 0.0263). Grade 4 or higher adverse event did not occur in either group. Creatinine levels in the cisplatin group rose 3 days after TACE or TAI (P = 0.0397).ConclusionCisplatin and miriplatin had equal efficacy for TACE and TAI, but cisplatin should be avoided for patients with renal dysfunction or inadequate hydration. Good TE improved overall survival.
Effectiveness of several solutions to prevent the formation of precipitate due to the interaction between sodium hypochlorite and chlorhexidine and its effect on bond strength of an epoxy‐based sealer
Authors: Magro M. G. , Kuga M. C. , Aranda‐Garcia A. J. , Victorino K. R. , Chávez‐Andrade G. M. , Faria G. , Keine K. C. , Só M. V. R. 
Published: June 2014

AbstractAimTo evaluate the effectiveness of isopropyl alcohol, saline or distilled water to prevent the precipitate formed between sodium hypochlorite (NaOCl) and chlorhexidine (CHX) and its effect on the bond strength of an epoxy‐based sealer in radicular dentine.MethodologyThe root canals of 50 extracted human canines (n = 10) were instrumented. In G1, root canals were irrigated with 17% EDTA and 2.5% NaOCl; G2, as G1, except that 2% CHX was used as the final irrigant. In the other groups, intermediate flushes with isopropyl alcohol (G3), saline (G4) or distilled water (G5) were used between NaOCl and CHX. The specimens were submitted to SEM analysis to evaluate the presence of debris and smear layer, in the apical and cervical segments. In sequence, fifty extracted human canines were distributed into five groups (n = 10), similar to the SEM study. After root filling, the roots were sectioned transversally to obtain dentine slices, in the cervical, middle and apical thirds. The root filling was submitted to a push‐out bond strength test using an electromechanical testing machine. Statistical analysis was performed using Kruskal–Wallis and Dunn's tests (α = 5%).ResultsAll groups had similar amounts of residue precipitated on the canal walls (P > 0.05). The push‐out bond strength values were similar for all groups, independently of the root third evaluated (P > 0.05).ConclusionsIsopropyl alcohol, saline and distilled water failed to prevent the precipitation of residues on canal walls following the use of NaOCl and CHX. The residues did not interfere with the push‐out bond strength of the root filling.
Low‐dose maintenance gemcitabine‐carboplatin chemotherapy could be an alternative to continuous standard chemotherapy for patients with metastatic urothelial carcinoma
Authors: Mitsuzuka Koji , Yamashita Shinichi , Namiki Shunichi , Yamada Shigeyuki , Sato Ko , Saito Hideo , Kaiho Yasuhiro , Ito Akihiro , Nakagawa Haruo , Arai Yoichi 
Published: June 2014

ObjectivesTo examine whether low‐dose maintenance gemcitabine‐carboplatin chemotherapy is beneficial for patients with metastatic urothelial carcinoma.MethodsWe retrospectively reviewed the records of 36 patients with metastatic urothelial carcinoma who received first‐line chemotherapy (gemcitabine/cisplatin, gemcitabine/carboplatin, or methotrexate/vinblastine/adriamycin/cisplatin) between 2006 and 2012. Those who had responded, but were unable to tolerate ongoing first‐line chemotherapy, had been switched to low‐dose maintenance chemotherapy consisting of 1 g/m2 of gemcitabine and area under the curve 2–4 of carboplatin given on day 1 of a 6‐week cycle, and were continued unless disease progression was seen.ResultsAfter a median of three cycles of first‐line chemotherapy, 17 patients had been switched to low‐dose maintenance chemotherapy. The median age was 70 years (range 56–79 years), and 12 patients (70.6%) had renal dysfunction (creatinine clearance <60 mL/min). The median number of cycles of low‐dose maintenance chemotherapy was six (range 2–22), and the median survival time from initiation of first‐line chemotherapy was 12 months (range 4–32 months). Adverse events requiring hospitalization were seen in three patients, but all of them recovered within a few days with conservative treatment. Seven patients discontinued within 9 months, whereas 10 patients continued on low‐dose maintenance chemotherapy for ≥9 months. Patients with only lymph node metastases or who had a good response to previous first‐line chemotherapy were likely to be able to continue low‐dose maintenance chemotherapy.ConclusionsLow‐dose maintenance gemcitabine‐carboplatin chemotherapy might represent an alternative for patients with metastatic urothelial carcinoma not tolerating continuous first‐line standard chemotherapy regimens.
Heuristics for the combined cut order planning two‐dimensional layout problem in the apparel industry
Authors: M'Hallah Rym , Bouziri Ahlem 
Published: June 2014

AbstractCut order planning (COP) is an NP‐hard nonlinear optimization problem. Managers of apparel manufacturing units face this problem during the planning of the first stage of the manufacturing process. It affects the fluidity of the work flow and use of fabric. It consists in dividing every garment's order into sections, assigning the sizes to them, and determining their lengths and numbers of layers such that the total fabric length is minimized. Current industrial practice assumes that the length of the layout of a section is known a priori, and it does not depend on its combination of sizes. That is, the industry solves COP independently of the two‐dimensional layout (TDL) that is the second stage of the manufacturing process. By relying on the length estimates in lieu of determining the actual length of a section, the industry is obtaining erroneous estimates of the true length used. Herein, COP and TDL are combined into a single problem CT (CT = COP + TDL) whose objective is to minimize fabric length. CT is solved using constructive heuristics, and three metaheuristics: a stochastic local improvement method, global improvement method, and hybrid approach. The approaches are tested on existing benchmark instances and new industrial cases. Their results provide computational proof of the benefits that industry can ripe by combining COP and TDL. The comparison of the performance of the approaches highlights their respective academic and practical utilities.
A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism
Authors: Salem Sandra , Gao Chan , Li Ailian , Wang Huifen , Nguyen‐Yamamoto Loan , Goltzman David , Henderson Janet E. , Gros Philippe 
Published: June 2014

AbstractIncreased risk of bone fractures is observed in patients with chronic inflammatory conditions, such as inflammatory bowel disease and rheumatoid arthritis. Members of the Interferon Response Factor family of transcriptional regulators, IRF1 and IRF8, have been identified as genetic risk factors for several chronic inflammatory and autoimmune diseases. We have investigated a potential role for the Irf1 gene in bone metabolism. Here, we report that Irf1−/−mutant mice show altered bone morphology in association with altered trabecular bone architecture and increased cortical thickness and cellularity. Ex vivo studies on cells derived from bone marrow stimulated with Rank ligand revealed an increase in size and resorptive activity of tartrate‐resistant acid‐positive cells from Irf1−/− mutant mice compared with wild‐type control mice. Irf1 deficiency was also associated with decreased proliferation of bone marrow‐derived osteoblast precursors ex vivo, concomitant with increased mineralization activity compared with control cells. We show that Irf1 plays a role in bone metabolism and suggest that Irf1 regulates the maturation and activity of osteoclasts and osteoblasts. The altered bone phenotype of Irf1−/− mutants is strikingly similar to that of Stat1−/− mice, suggesting that the two interacting proteins play a critical enabling role in the common regulation of these two cell lineages.
Oxidative Stress Is Related to Frailty, Not to Age or Sex, in a Geriatric Population: Lipid and Protein Oxidation as Biomarkers of Frailty
Authors: Inglés Marta , Gambini Juan , Carnicero Jose A. , García‐García Francisco J. , Rodríguez‐Mañas Leocadio , Olaso‐González Gloria , Dromant Mar , Borrás Consuelo , Viña Jose 
Published: June 2014

ObjectivesTo ascertain whether indicators of oxidative damage to lipids (malondialdehyde (MDA)) and proteins (protein carbonylation) are biomarkers of frailty, after adjusting for age, sex, and other possible confounders.DesignCross‐sectional cohort study.SettingCommunity.ParticipantsToledo Study for Healthy Aging participants (N = 742, aged 65–95), classified as frail (n = 54), prefrail (n = 278) and nonfrail (n = 410) according to the Fried criteria.MeasurementsBlood plasma was obtained using centrifugation (1,500 G, 15 minutes) and immediately frozen at −80°C. Plasma lipid peroxidation was determined by measuring the MDA formed from lipoperoxides using high‐performance liquid chromatography and protein carbonylation was measured using Western blot.ResultsAge‐ and sex‐adjusted levels of lipoperoxides (measured as MDA) and protein carbonylation in plasma proved to be related to frailty, even after including possible independent confounders.ConclusionCirculating oxidative damage biomarkers, such as MDA and protein carbonylation, are related to frailty and not to age or sex. These parameters may be considered as potential biomarkers of frailty in the context of a multidisciplinary health‐promoting approach for older adults.
Enhancing Communication in End‐of‐Life Care: A Clinical Tool Translating Between the Clinical Frailty Scale and the Palliative Performance Scale
Authors: Grossman Daphna , Rootenberg Mark , Perri Giulia‐Anna , Yogaparan Thirumagal , DeLeon Maria , Calabrese Sue , Grief Cindy J. , Moore Jennifer , Gill Ashlinder , Stilos Kalli , Daines Patricia , Zimmermann Camilla , Mazzotta Paolo 
Published: June 2014

ObjectivesTo create a clinical tool to translate between the Clinical Frailty Scale (CFS), which geriatrics teams use, and Palliative Performance Scale (PPS), which palliative care teams use, to create a common language and help improve communication between geriatric and palliative care teams.DesignCross‐sectional.SettingsTwo academic health centers: inpatient palliative care and chronic care units, an outpatient geriatric clinic, and inpatient referrals to a palliative care consultation service.ParticipantsOlder adults (≥65) aged 80.9 ± 8.0, with malignant (51%) and nonmalignant (49%) terminal diagnoses (N = 120).MeasurementsEach participant was assigned four scores: a CFS score each from a geriatric physician and nurse and a PPS score each from a palliative care physician and nurse. Interrater reliability of each measure was calculated using kappa coefficients. For each measure, the mean of physician and nurse scores was used to calculate every possible combination of CFS and PPS scores to determine the combination with maximum agreement.ResultsInterrater reliability of each measure was very high for the CFS (weighted κ = 0.92) and PPS (weighted κ = 0.80). The CFS–PPS score matching that achieved maximum agreement (weighted κ = 0.71) was used to create a conversion chart between the two measures.ConclusionThis conversion chart is a reliable means of translating scores between the CFS and PPS and is useful for geriatric and palliative care teams collaborating in the care of elderly adults.
Evaluation of a Symptom‐Triggered Protocol Approach to the Management of Alcohol Withdrawal Syndrome in Older Adults
Authors: Taheri Asal , Dahri Karen , Chan Peter , Shaw Maureen , Aulakh Amneet , Tashakkor Amir 
Published: June 2014

ObjectivesTo evaluate whether implementation of symptom‐triggered administration of a benzodiazepine protocol reduces the severity (total cumulative dose), duration, and complications of alcohol withdrawal syndrome (AWS).DesignRetrospective health record review.SettingTertiary care center in Vancouver, Canada.ParticipantsIndividuals aged 70 and older admitted to the Acute Care for Elders and Acute Medicine Unit wards with diagnostic codes for AWS from 2008 to 2012.MeasurementsMedian duration and cumulative dose of benzodiazepine treatment, number of severe AWS complications, severe benzodiazepine‐associated adverse effects, and need for adjunct therapy.ResultsThirty‐three participants in the preprotocol group and 30 in the protocol‐implemented group met the inclusion criteria. Median duration of benzodiazepine treatment decreased from 96 hours (interquartile range (IQR) 72–120 hours) in the preprotocol period to 48 hours (IQR 0–108 hours; P = .04), and median cumulative benzodiazepine dose administered decreased from 9 mg (IQR 5–19.8 mg) to 3 mg (IQR 0–10 mg; P = .001). Statistically significantly lower incidence of severe AWS complications (P = .007) and adjunct therapy use (P = .02) was seen in the protocol‐implemented group.ConclusionA symptom‐triggered protocol for dosing of benzodiazepine therapy in the management of AWS in individuals aged 70 and older significantly reduced the total duration of benzodiazepine use, cumulative benzodiazepine dose, and use of adjunctive medications in the treatment of AWS.
Validity and reliability of the Turkish version of the Maternal Antenatal Attachment Scale
Authors: Golbasi Zehra , Ucar Tuba , Tugut Nilufer 
Published: June 2014

AbstractAimThe objective of this study was to translate the Maternal Antenatal Attachment Scale (MAAS) into Turkish, to adapt it to Turkish cultural conditions, and to determine its validity and reliability.MethodsThis study was conducted in a state hospital in the Central Anatolia Region, Sivas, Turkey. A total of 190 pregnant women were included in the study. Data was collected by MAAS. The validity of language, content, and construct were examined to evaluate the validity of the MAAS. Cronbach's alpha was used to assess internal consistency reliability.ResultsThe consistency of specialist opinion on the scale, translated into Turkish and back‐translated, was determined (Kendall W = 0.11; P > 0.05). The factor loadings resulting from the factor analysis directed at the construct validity of the scale were in the 0.33–0.71 range, and the items were grouped under two factors. Cronbach's alpha reliability coefficient overall for the entire scale was 0.79; it was calculated as being 0.76 for the first sub‐dimension (11 items) and 0.65 for the second sub‐dimension (eight items).ConclusionThe Turkish version of the MAAS is a valid and reliable tool for the evaluation of the maternal–fetal attachment level in the antenatal period