bluuebunny/crossref_metadata_2025_split huggingface dataset:
AI‐based digital pathology provides newer insights into lifestyle intervention‐induced fibrosis regression in MASLD: An exploratory study
Authors: Yuan Hai‐Yang , Tong Xiao‐Fei , Ren Ya‐Yun , Li Yang‐Yang , Wang Xin‐Lei , Chen Li‐Li , Chen Sui‐Dan , Jin Xiao‐Zhi , Wang Xiao‐Dong , Targher Giovanni , Byrne Christopher D. , Wei Lai , Wong Vincent W.‐S , Tai Dean , Sanyal Arun J. , You Hong , Zheng Ming‐Hua 
Published: July 2024

AbstractBackground and AimsLifestyle intervention is the mainstay of therapy for metabolic dysfunction‐associated steatohepatitis (MASH), and liver fibrosis is a key consequence of MASH that predicts adverse clinical outcomes. The placebo response plays a pivotal role in the outcome of MASH clinical trials. Second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) microscopy with artificial intelligence analyses can provide an automated quantitative assessment of fibrosis features on a continuous scale called qFibrosis. In this exploratory study, we used this approach to gain insight into the effect of lifestyle intervention‐induced fibrosis changes in MASH.MethodsWe examined unstained sections from paired liver biopsies (baseline and end‐of‐intervention) from MASH individuals who had received either routine lifestyle intervention (RLI) (n = 35) or strengthened lifestyle intervention (SLI) (n = 17). We quantified liver fibrosis with qFibrosis in the portal tract, periportal, transitional, pericentral, and central vein regions.ResultsAbout 20% (7/35) and 65% (11/17) of patients had fibrosis regression in the RLI and SLI groups, respectively. Liver fibrosis tended towards no change or regression after each lifestyle intervention, and this phenomenon was more prominent in the SLI group. SLI‐induced liver fibrosis regression was concentrated in the periportal region.ConclusionUsing digital pathology, we could detect a more pronounced fibrosis regression with SLI, mainly in the periportal region. With changes in fibrosis area in the periportal region, we could differentiate RLI and SLI patients in the placebo group in the MASH clinical trial. Digital pathology provides new insight into lifestyle‐induced fibrosis regression and placebo responses, which is not captured by conventional histological staging.
Raman spectroscopy of Ryugu particles and their extracted residues: Fluorescence background characteristics and similarities to CI chondrites
Authors: Komatsu Mutsumi , Yabuta Hikaru , Kebukawa Yoko , Bonal Lydie , Quirico Eric , Fagan Timothy J. , Cody George D. , Barosch Jens , Bejach Laure , Dartois Emmanuel , Dazzi Alexandre , De Gregorio Bradley , Deniset‐Besseau Ariane , Duprat Jean , Engrand Cecile , Hashiguchi Minako , Martins Zita , Mathurin Jérémie , Montagnac Gilles , Mostefaoui Smail , Nittler Larry R. , Ohigashi Takuji , Okumura Taiga , Rémusat Laurent , Sandford Scott , Stroud Rhonda , Suga Hiroki , Takahashi Yoshio , Takeichi Yasuo , Tamenori Yusuke , Verdier‐Paoletti Maximilien , Yamashita Shohei , Yurimoto Hisayoshi , Nakamura Tomoki , Noguchi Takaaki , Okazaki Ryuji , Naraoka Hiroshi , Sakamoto Kanako , Yoshikawa Makoto , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Nakazawa Satoru , Usui Tomohiro , Abe Masanao , Okada Tatsuaki , Yada Toru , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Yogata Kasumi , Tachibana Shogo , Watanabe Sei‐ichiro , Tsuda Yuichi 
Published: July 2024

AbstractWe present here an investigation of Ryugu particles recovered by the Hayabusa2 space mission and their extracted carbonaceous acid residues using Raman spectroscopy. Raman parameters of Ryugu intact grains and their acid residues are characterized by broad D (defect induced) and G (graphite) band widths, indicating the presence of polyaromatic carbonaceous matter with low thermal maturity. Raman spectra of Ryugu particles and CI (type 1) chondrites exhibit stronger laser‐induced fluorescence backgrounds compared to Type 2 and Type 3 carbonaceous chondrites. The high fluorescence signatures and wide bandwidths of the D and G bands of Ryugu intact grains are similar to the Raman spectra observed in CI chondrites, reflecting the low structural order of their aromatic carbonaceous matter, and strengthening the link between Ryugu particles and CI chondrites. The high fluorescence background intensity of the Ryugu particles is due to multiple causes, but it is likely that the relative abundance of geometry‐bearing macromolecular organic matter in total organic carbon contents makes a large contribution to the fluorescence intensities. Locally observed high fluorescence in the acid‐extracted residues of Ryugu is due to nitrogen‐bearing outlier phase. The high fluorescence signature is one consequence of the low degree of thermal maturity of the organic matter and supports evidence that the Ryugu particles have escaped significant parent body thermal metamorphism.
Reliability of anthropometric measurements of a digi‐board in comparison to an analog height board in Namibian children under 5 years
Authors: Namene Johanna , Hunter Christian J. , Hodgson Shirley , Hodgson Humphrey , Misihairabgwi Jane , Huang Shan , Conkle Joel 
Published: July 2024

AbstractPoor measurement quality has set back the utility of anthropometry in defining childhood malnutrition, prompting calls for alternative measurement techniques. This study aimed to assess the reliability of anthropometric measurements using a digital height board in comparison to an analog height board in Namibian children under 5 years of age. A cross‐sectional, descriptive study was conducted (n = 425) between the age of 6 and 59 months, using anthropometric measurements of weight, height and mid‐upper arm circumference. Two trained enumerators each collected four height measurements of each child: two using an analog height board and two using a digi‐board. The repeated height measurements between and within the enumerators were used to determine intra‐ and interobserver reliability. Reliability of the digi‐board was assessed using the technical error of measurement (TEM), relative TEM (%TEM), intraclass correlation and a Bland–Altman analysis to assess the agreement between the two methods. In all these assessments, the analog height board was considered as the gold standard and used for comparison. The digi‐board showed superiority to the analog height board in terms of reliability (analog TEM = 0.22, digi‐board TEM = 0.16). Although the digi‐board has potential to improve child anthropometry, further clinical and large survey studies are needed to validate the used of this tool in routine population‐based surveys.
Complex intertwined association between breastfeeding practices and household food insecurity: Systematic review and meta‐analysis
Authors: Buccini Gabriela , Larrison Cali , Neupane Smriti , Palapa Maria , Schincaglia Raquel Machado , Brown Sara , Gubert Muriel B. 
Published: July 2024

AbstractBreastfeeding offers ideal food and nutrition for infants; however, structural barriers may amplify breastfeeding inequities. We aimed to identify whether household food insecurity (HFI) is associated with exclusive and continued breastfeeding (EBF and CBF) as recommended by the World Health Organization/United Nations Children's Fund (UNICEF) Following the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis, literature searches using ‘breastfeeding’, ‘food insecurity’ and ‘infant’ terms were conducted in PubMed/MEDLINE, Embase, CINAHL, Global Health and LILACS from inception through November 2023, without language restrictions, yielding 1382 publications (PROSPERO:CRD42022329836). Predetermined eligibility criteria yielded the 12 included studies (nine cross‐sectional and three cohorts). The risk of bias was assessed through the Effective Public Health Practice Project. Meta‐analysis was performed for studies assessing EBF (n = 10), and metaregression was used to explore heterogeneity across studies. Prevalence of EBF ranged from 1.6% to 85.3%, with a lower prevalence among HFI. The pooled effect of the association between HFI and EBF presented an odds ratio (OR) of 0.61 (95% CI = 0.49–0.76) with consistent results across marginal (OR = 0.72, 95% CI = 0.55–0.94), moderate (OR = 0.59, 95% CI = 0.41–0.84) and severe HFI (OR = 0.49, 95% CI = 0.32–0.76). High heterogeneity was found only when HFI was dichotomized. The prevalence of CBF ranged from 35.4% to 78.0%, with inconsistent prevalence among HFI; a meta‐analysis was not performed due to the low number of studies (n = 3). We concluded that HFI levels are associated with lower odds of EBF. Integrating service and policy‐level strategies, such as screening, referrals, skilled breastfeeding counseling and access to comprehensive nutrition and social programs, could reduce structural inequities and promote adherence to the World Health Organization/UNICEF breastfeeding recommendations among food‐insecure families.
Genome resequencing reveals population divergence and local adaptation of blacklegged ticks in the United States
Authors: Schoville Sean D. , Burke Russell L. , Dong Dahn‐young , Ginsberg Howard S. , Maestas Lauren , Paskewitz Susan M. , Tsao Jean I. 
Published: July 2024

AbstractTick vectors and tick‐borne disease are increasingly impacting human populations globally. An important challenge is to understand tick movement patterns, as this information can be used to improve management and predictive modelling of tick population dynamics. Evolutionary analysis of genetic divergence, gene flow and local adaptation provides insight on movement patterns at large spatiotemporal scales. We develop low coverage, whole genome resequencing data for 92 blacklegged ticks, Ixodes scapularis, representing range‐wide variation across the United States. Through analysis of population genomic data, we find that tick populations are structured geographically, with gradual isolation by distance separating three population clusters in the northern United States, southeastern United States and a unique cluster represented by a sample from Tennessee. Populations in the northern United States underwent population contractions during the last glacial period and diverged from southern populations at least 50 thousand years ago. Genome scans of selection provide strong evidence of local adaptation at genes responding to host defences, blood‐feeding and environmental variation. In addition, we explore the potential of low coverage genome sequencing of whole‐tick samples for documenting the diversity of microbial pathogens and recover important tick‐borne pathogens such as Borrelia burgdorferi. The combination of isolation by distance and local adaptation in blacklegged ticks demonstrates that gene flow, including recent expansion, is limited to geographical scales of a few hundred kilometres.
The root‐knot nematode effector MiEFF12 targets the host ER quality control system to suppress immune responses and allow parasitism
Authors: Soulé Salomé , Huang Kaiwei , Mulet Karine , Mejias Joffrey , Bazin Jérémie , Truong Nhat My , Kika Junior Lusu , Jaubert Stéphanie , Abad Pierre , Zhao Jianlong , Favery Bruno , Quentin Michaël 
Published: July 2024

AbstractRoot‐knot nematodes (RKNs) are microscopic parasitic worms able to infest the roots of thousands of plant species, causing massive crop yield losses worldwide. They evade the plant's immune system and manipulate plant cell physiology and metabolism to transform a few root cells into giant cells, which serve as feeding sites for the nematode. RKN parasitism is facilitated by the secretion in planta of effector molecules, mostly proteins that hijack host cellular processes. We describe here a conserved RKN‐specific effector, effector 12 (EFF12), that is synthesized exclusively in the oesophageal glands of the nematode, and we demonstrate its function in parasitism. In the plant, MiEFF12 localizes to the endoplasmic reticulum (ER). A combination of RNA‐sequencing analysis and immunity‐suppression bioassays revealed the contribution of MiEFF12 to the modulation of host immunity. Yeast two‐hybrid, split luciferase and co‐immunoprecipitation approaches identified an essential component of the ER quality control system, the Solanum lycopersicum plant bap‐like (PBL), and basic leucine zipper 60 (BZIP60) proteins as host targets of MiEFF12. Finally, silencing the PBL genes in Nicotiana benthamiana decreased susceptibility to Meloidogyne incognita infection. Our results suggest that EFF12 manipulates PBL function to modify plant immune responses to allow parasitism.
The effect of telecounseling on depression in primiparous mothers during the postpartum period: A randomized controlled trial
Authors: Koç Emine , Baltaci Nazlı , Bal Sümeyye 
Published: July 2024

AbstractPostpartum depression is one of the most common mental health disorders in women after giving birth. This study was conducted to examine the effect of telecounseling support on depression in primiparous mothers. This study was conducted as a randomized controlled trial with a parallel group pretest–posttest design. The study comprised 50 participants each in the intervention and control groups. Face‐to‐face interviews were conducted with all participants, and the Maternal Information Form and the Edinburgh Postpartum Depression Scale (EPDS) were administered. The intervention group received telecounseling for 6 weeks, while the control group received routine postnatal care. After the 6‐week period, EPDS was re‐administered to both groups. In the intervention group, the EPDS mean score decreased from 7.12 ± 3.96 to 6.34 ± 3.73 after telecounseling (p < 0.001). Conversely, in the control group, the EPDS mean score increased from 6.62 ± 3.55 to 7.90 ± 4.65 without any intervention (p = 0.002). The results indicate that telecounseling is an effective method for reducing the risk of depression among mothers during the postpartum period. It is recommended that healthcare professionals extend their support by providing telecounseling for mothers.
The biosynthesis of storage reserves and auxin is coordinated by a hierarchical regulatory network in maize endosperm
Authors: Song Teng , Huo Qiang , Li Chaobin , Wang Qun , Cheng Lijun , Qi Weiwei , Ma Zeyang , Song Rentao 
Published: July 2024

Summary

Grain filling in maize (Zea mays) is intricately linked to cell development, involving the regulation of genes responsible for the biosynthesis of storage reserves (starch, proteins, and lipids) and phytohormones. However, the regulatory network coordinating these biological functions remains unclear.

In this study, we identified 1744 high‐confidence target genes co‐regulated by the transcription factors (TFs) ZmNAC128 and ZmNAC130 (ZmNAC128/130) through chromatin immunoprecipitation sequencing coupled with RNA‐seq analysis in the zmnac128/130 loss‐of‐function mutants. We further constructed a hierarchical regulatory network using DNA affinity purification sequencing analysis of downstream TFs regulated by ZmNAC128/130.

In addition to target genes involved in the biosynthesis of starch and zeins, we discovered novel target genes of ZmNAC128/130 involved in the biosynthesis of lipids and indole‐3‐acetic acid (IAA). Consistently, the number of oil bodies, as well as the contents of triacylglycerol, and IAA were significantly reduced in zmnac128/130. The hierarchical regulatory network centered by ZmNAC128/130 revealed a significant overlap between the direct target genes of ZmNAC128/130 and their downstream TFs, particularly in regulating the biosynthesis of storage reserves and IAA.

Our results indicated that the biosynthesis of storage reserves and IAA is coordinated by a multi‐TFs hierarchical regulatory network in maize endosperm.
Clinical benefit of botulinum toxin for treatment of persistent TMD‐related myofascial pain: A randomized, placebo‐controlled, cross‐over trial
Authors: Sitnikova V. , Kämppi A. , Kämppi L. , Alvesalo E. , Burakova M. , Kemppainen P. , Teronen O. 
Published: July 2024

AbstractBackgroundInjections of botulinum toxin type A (BoNT‐A) have been proposed as an additional treatment modality for patients suffering chronic temporomandibular disorder (TMD)‐related myofascial pain (MFP). BoNT‐A impairs muscle function, along with its analgesic effect, and a minimal effective dose should be used. The objective of this randomized placebo‐controlled crossover study was to evaluate the clinical benefit of a moderate dose (50 U) of BoNT‐A.MethodsSixty‐six subjects were randomized into two groups, one which received BoNT‐A first and a second which received a saline solution (SS) first. Follow‐ups were performed 2, 11, and 16 weeks after the injections. Diagnostic criteria for temporomandibular disorders (DC/TMD) diagnostic algorithms were used to evaluate characteristic pain intensity (CPI) and pain‐related disability based on the Graded Chronic Pain Scale (GCPS). Electromyographic and bite force were also evaluated.ResultsThe within‐group analysis showed a significant improvement in pain intensity and pain‐related disability after BoNT‐A (p < 0.001, p = 0.005, p = 0.011) and SS (p = 0.003, p = 0.005, p = 0.046) injections up to week 16. The between‐group analysis of pain‐related variables revealed no differences between groups at any time. Nonetheless, BoNT‐A, but not SS, caused a significant decline in muscle performance. The number needed to treat (NNT) regarding a clinically significant pain reduction (≥30%) was 6.3, 57.0, and 19.0 at 2, 11, and 16‐week follow‐ups favoring BoNT‐A.ConclusionsInjections of 50 U of BoNT‐A might improve MFP symptoms, but the specific effect of the drug on pain compared to the placebo is not obvious.
Livedo‐like acute cutaneous graft‐versus‐host disease in two children
Authors: Alvarez‐Alatriste Maria Fernanda , Olaya‐Vargas Alberto , Melchor‐Vidal Yadira Berenice , Garcia‐Romero Maria Teresa 
Published: July 2024

AbstractWe present two pediatric patients who exhibited an unusual clinical presentation of cutaneous acute graft‐versus‐host disease (GVHD), characterized by livedo‐like appearance. Such manifestations of cutaneous acute GVHD have not been previously documented.
Linking social reward responsiveness and affective responses to the social environment: An ecological momentary assessment study
Authors: Dell'Acqua Carola , Allison Grace O. , Yun Connie H. , Weinberg Anna 
Published: July 2024

AbstractSocial support is a key predictor of well‐being, but not everyone experiences mental health benefits from receiving it. However, given that a growing number of interventions are based on social support, it is crucial to identify the features that make individuals more likely to benefit from social ties. Emerging evidence suggests that neural responses to positive social feedback (i.e., social reward) might relate to individual differences in social functioning, but potential mechanisms linking these neural responses to psychological outcomes are yet unclear. This study examined whether neural correlates of social reward processing, indexed by the reward positivity (RewP), relate to individuals' affective experience following self‐reported real‐world positive social support events. To this aim, 193 university students (71% females) underwent an EEG assessment during the Island Getaway task and completed a 10‐day ecological momentary assessment where participants reported their positive and negative affects (PA, NA) nine times a day and the count of daily positive and negative events. Experiencing a higher number of social support positive events was associated with higher PA. The RewP moderated this association, such that individuals with greater neural response to social feedback at baseline had a stronger positive association between social support positive events count and PA. Individual differences in the RewP to social feedback might be one indicator of the likelihood of experiencing positive affect when receiving social support.
Approaches to studying emotion using physiological responses to spoken narratives: A scoping review
Authors: Savard Marie‐Anick , Merlo Raphaëlle , Samithamby Abiraam , Paas Anita , Coffey Emily B. J. 
Published: July 2024

AbstractNarratives are effective tools for evoking emotions, and physiological measurements provide a means of objectively assessing emotional reactions – making them a potentially powerful pair of tools for studying emotional processes. However, extent research combining emotional narratives and physiological measurement varies widely in design and application, making it challenging to identify previous work, consolidate findings, and design effective experiments. Our scoping review explores the use of auditory emotional narratives and physiological measures in research, examining paradigms, study populations, and represented emotions. Following the PRISMA‐ScR Checklist, we searched five databases for peer‐reviewed experimental studies that used spoken narratives to induce emotion and reported autonomic physiological measures. Among 3466 titles screened and 653 articles reviewed, 110 studies were included. Our exploration revealed a variety of applications and experimental paradigms; emotional narratives paired with physiological measures have been used to study diverse topics and populations, including neurotypical and clinical groups. Although incomparable designs and sometimes contradictory results precluded general recommendations as regards which physiological measures to use when designing new studies, as a whole, the body of work suggests that these tools can be valuable to study emotions. Our review offers an overview of research employing narratives and physiological measures for emotion study, and highlights weaknesses in reporting practices and gaps in our knowledge concerning the robustness and specificity of physiological measures as indices of emotion. We discuss study design considerations and transparent reporting, to facilitate future using emotional narratives and physiological measures in studying emotions.
Mandibular fracture in medication‐associated osteonecrosis following infliximab therapy: A case report
Authors: Kolodziejwski Waleska Tychanowicz , Rosa Camila Adriane Leffa , Guimarães Angela Maira , da Silva Priscila Queiroz Mattos , de Araujo Melissa Rodrigues 
Published: July 2024

AbstractIntroductionMedication‐associated osteonecrosis of the jaws (MRONJ) is characterized by the presence of exposed bone or an intraoral or extraoral fistula in the maxillofacial region in patients with a history of treatment with anti‐resorptive and anti‐angiogenic drugs, such as monoclonal antibodies, and without a history of radiotherapy or metastatic diseases in the area.ObjectiveThe aim of this study is to report a case of a pathological mandibular fracture in an area of MRONJ in a patient diagnosed with Crohn's disease treated with infliximab.Case reportA 53‐year‐old male patient, an active smoker for 35 years, diagnosed with Crohn's disease, undergoing intravenous administration of infliximab 300 mg for 1 year and 3 months, with no previous history of anti‐angiogenic or anti‐resorptive medication, presenting with an extraoral fistula in the submandibular region for 4 months, with painful symptoms, diagnosed as MRONJ. He was initially treated conservatively, using antimicrobial photodynamic therapy (aPDT), antibiotic therapy, and the PENTO protocol. However, the patient evolved with a pathological fracture in the mandibular parasymphysis, requiring surgical reconstruction.Final considerationsPathological fracture of the mandible is a complication of MRONJ that compromises the patient's quality of life. The management of patients with MRONJ is complex and challenging.