bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEPRESI POST PARTUM DAN INVERTED NIPPLE GRADE 1 MENGHAMBAT PRAKTIK PEMBERIAN ASI
Authors: Yoga M Agung Prasetya Adnyana , Anggraini Dian Isti , Saftarina Fitria 
Published: June 2024

Breast milk is the best food for infants because it contains complete nutritional values to support infant growth and development. However, anatomical abnormalities in the nipple such as inverted nipple and psychological factors of post partum depression affect the success of breastfeeding practices. This study was design to determine the effect of post partum depression and inverted nipple grade 1 on breastfeeding practices. This study was used a case study method with a nutritional needs management approach for breastfeeding mothers on respondents who breastfeed babies aged 16 months, the Edinburgh Postnatal Depression Scale (EPDS) questionnaire is used to assess post partum depression and if the EPDS score ≥ 10 then the mother is indicated to have post partum depression. Data regarding inverted nipple in mothers using secondary data. Food recall 1 x 2 4 hours was used to assess the mother's food consumption pattern followed by calculation of the level of nutrient fulfilment to quantitatively assess the mother's macronutrient intake in terms adequate or inadequate category. The total EDPS score was 13 so that the mother was included in post partum depression and based on secondary data and Aesthetic Surgery diagnosis guidelines, the mother was categorised as having inverted nipple grade 1. Both factors can hinder the continuity of breastfeeding practices. Support from husband and family as well as using the breast pump method on inverted nipples can help mothers to produce adequate amounts of breast milk. Quantitative analysis of the level of fulfilment of maternal nutrients in the adequate category, namely energy intake of 113% (good), protein intake of 113% (good), fat intake of 82% (moderate) and carbohydrate intake of 111% (good). Post partum depression and inverted nipple can inhibit breastfeeding practices, so premarital counselling and education about psychological disorders and anatomical abnormalities of the nipple during antenatal care (ANC) are needed for mothers and husbands to increase the success of breastfeeding practices for infants.
Bimbingan Teknis Penyusunan Rencana Usaha Bagi Calon Pendamping Usaha Kecil Dan Menengah
Authors: Mulyana Iwan 
Published: June 2024

Pendampingan merupakan kegiatan membantu calon-calon usaha kecil menengah yang akan dan berkeinginan untuk membuka usaha atau para pelaku UKM yang ingin mengembangkan usahanya sehingga mereka mampu mengimplementasikan bisnisnya menjadi sesuatu yang riil atau berjalan sesuai dengan tujuan yang ingin dicapai mereka. Kegiatan pendampingan ini harus dilakukan oleh orang yang mempunyai keahlian (skill) baik dari segi hard skill maupun soft skill. Oleh karena itu para pendamping harus diberi pembekalan dengan kemampuan-kemampuan tersebut. Salah satu kemampuan yang dimiliki adalah penyusunan rencana usaha, sehingga dalam kegiatan bimtek tersebut disampaikan topik materi tentang penyusunan rencana Usaha. Metode penyampaian topik tersebut diberikan dengan cara pemaparan materi kemudian pemberian contoh-contoh rencana usaha pada berbagai jenis usaha dan diakhiri dengan diskusi. Kegiatan bimtek ini dijadikan sebagai dasar untuk memberikan pemahaman kepada pendamping yang akan terjun langsung ke lapangan di daerah Papua.
Pelatihan Manajemen Koperasi Simpan Pinjam/Unit Simpan Pinjam Pola Syariah Koperasi Kota Bandung
Authors: Sobarna Nanang 
Published: June 2024

Koperasi Syariah membutuhkan Sumber Daya Insani yang memiliki pengetahuan dan kompetensi dalam pengelolaan Koperasi karena Sumber Daya Insani memiliki peranan yang sangat penting dalam mendorong kemajuan dan perkembangan Koperasi Syariah yang berpegang pada prinsip-prinsip syariah. Pelatihan Manajemen Koperasi Simpan Pinjam/Unit Simpan Pinjam Pola Syariah dilaksanakan dengan tujuan agar para peserta sebagai pengelola Koperasi Syariah memiliki pengetahuan dan kemampuan dalam mengelola Koperasinya sehingga usaha Koperasi Syariah dapat maju dan berkembang. Dengan demikian tujuan Koperasi dapat tercapai, yaitu mampu memajukan kesejahteraan anggota dan masyarakat. Selain itu, pelatihan ini dilaksanakan agar dalam mengoperasionalkan Koperasi Syariah tidak bertentangan dengan prinsip-prinsip syariah. Metode Pelatihan yang digunakan dalam kegiatan ini adalah metode ceramah yang dilanjutkan dengan tanya jawab dan diskusi seputar permasalahan yang dihadapi dalam pengelolaan Koperasi Syariah disertai penyampaian solusi. Dari kegiatan pelatihan ini, peserta mendapatkan pengetahuan dan kemampuan mengenai manajemen Koperasi Syariah.
Pendidikan Dan Pelatihan Pemecahan Masalah Dan Pengambilan Keputusan Bagi Pengurus Koperasi
Authors: Supriyadi R Ery , Hamdani Dadan 
Published: June 2024

Kemampuan merancangbangun sediaan informasi, tata cara olahan data dan visualisasi informasi menjadi bahan pengambilan keputusan sangat diperlukan bagi pengelola pengurus koperasi dalam mengelola organisasi dan usaha koperasi. Proses pemilihan alternatif, model pengambilan keputusan dan tindak lanjut keputusan menjadi kebutuhan bagi pengurus dalam melaksanakan fungsi pengarahan dan pengendalian informasi bagi pelayanan, promosi, dan hubungan pasar. Artikel ini mendeskripsikan pendidikan dan pelatihan pemecahan masalah dan pengambilan keputusan bagi pengurus koperasi dengan multi metode terdapat komponen utama pengenalan masalah dan pemecahanan, serta model pengambilan keputusan, yaitu definisi dan pemecahan masalah, cara pemecahan masalah, proses pengambilan keputusan, kemampuan pengambilan keputusan, strukturisasi pemecahan masalah, pendekatan dan model pengambilan keputusan, pemecahan masalah melalui peta strategik. Penguatan pengurus dan atau anggota koperasi sebagai calon pengurus koperasi mampu mengenali masalah secara tepat, memberikan solusi alternatif dalam mengatasi masalah yang dihadapi, dan mengambil keputusan dengan berbagai pilihan modelnya. Pendidikan dan pelatihan sebagai bentuk pengabdian kepada masyarakat bermanfaat bagi upaya pencapaian tujuan pelayanan koperasi kepada anggotanya, mempromosi usaha anggota, meningkatkan akses informasi pasar, meningkatnya ekonomi anggota, mempermudah akses manajemen dan keuangan koperasi, serta layanan anggota koperasi.
Peningkatan Literasi Financial Technology (Fintech) Dan Risiko Hukumnya Dalam Mendukung Bisnis Online Bagi Siswa SMK Di Kota Bandung
Authors: Nurjamil Nurjamil , Supriyatni Renny , Soerjati Enni 
Published: June 2024

Pengabdian Kepada Masyarakat (Abdimas) ini dilakukan untuk meningkatkan tingkat literasi atau pemahaman masyarakat khususnya siswa-siswa Sekolah Menengah Kejuruan (SMK) yang mempunyai aktivitas dalam kegiatan bisnis secara online mengenai penggunaan aplikasi atau layanan fintech (financial technology) sebagai alternatif pembiayaan usaha sekaligus mitigasi risiko hukum yang dapat muncul di dalamnya. Metode yang digunakan adalah penyampaian materi model seminar dan diskusi interaktif secara hybrid melalui layanan aplikasi zoom yang diikuti oleh sebagian siswa yang hadir di aula sekolah dan sebagian lainnya mengikuti secara online. Setelah dilakukan survey dengan menyebarkan kuesioner dalam Google Form, hasilnya menunjukkan bahwa sebagian besar peserta merasakan manfaat dari kegiatan abdimas sehingga tingkat literasi mereka semakin meningkat, sebanyak 58,2% atau 121 peserta mengatakan Abdimas tersebut sangat bermanfaat, 40,4% atau 84 peserta mengatakan bermanfaat, 1,4% atau 3 peserta mengatakan cukup bermanfaat. Hal tersebut diketahui dengan pemahaman para peserta tentang konsep fintech, risiko hukum dan mitigasi risikonya yang semakin meningkat dalam menjawab pertanyaan post test yang dilakukan. Hasil post test menunjukkan 90% peserta menjawab dengan benar
Sosialisasi Jati Diri dan Pendirian Koperasi Bagi Ikatan Alumni Biologi Universitas Andalas, Padang, Sumatera Barat
Authors: Fahmi Indra 
Published: June 2024

Kamus Besar Bahasa Indonesia (KBBI) memberikan pengertian mengenai Jati diri yang memiliki makna ciri, gambaran, atau keadaan khusus suatu benda. Makna lain dari jati diri adalah identitas. Dari makna ini dapat diartikan bahwa jati diri koperasi adalah identitas atau ciri atau gambaran atau keadaan khusus organisasi koperasi yang membedakannya dengan organisasi bisnis lainnya. Jati diri koperasi meliputi pengertian, nilai-nilai, dan prinsip koperasi, yang dari konsepsi ini akan terlihat perbedaan koperasi dengan organisasi bisnis lainnya. Banyaknya badan usaha yang didirikan dengan nama koperasi yang di dalam praktik operasional dan usahanya sering kali tidak menerapkan nilai-nilai dan prinsip koperasi. Hal ini berdampak pada akhirnya “koperasi” yang didirikan tersebut hanya namanya saja sebagai koperasi, namun ruh dan operasionalnya tidaklah sesuai dengan jati diri koperasi. Kondisi ini dapat menyebabkan ketidakmampuan pencapaian tujuan berkoperasi, penyimpangan dalam pengelolaan usaha/bisnis dan operasional koperasi. Sehingga banyak terjadi Koperasi-Koperasi yang gagal dan ini berakibat pada hilangnya kepercayaan masyarakat terhadap organisasi yang bernama Koperasi. Oleh karena itu, menjadi hal penting bagi orang-orang yang akan mendirikan koperasi dan para pengelola koperasi untuk memahami jati diri koperasi. Atas dasar pertimbangan inilah, Ikatan Keluarga Alumni Jurusan Biologi Universitas Andalas (IKABIOLOGI UNAND), Padang, Sumatera Barat, yang akan mendirikan koperasi, memandang perlu untuk membekali diri berkaitan dengan perkoperasian melalui sebuah seminar yang berbasis web (Webinar) dengan tema “Kupas Tuntas Koperasi di Jaman Now”
The Selection of an E-Wallet by Mathematics Students at the University of North Sumatra Using the Analytical Hierarchy Process (AHP) Method
Authors: Siringoringo Yan Batara Putra , Tiovanny Angel , Waruwu Cindy Berlianti , Simanjuntak Jelita Octavia 
Published: June 2024

Choosing an e-wallet is an important decision for students at the University of North Sumatra (USU) because it affects their financial management. The Analytical Hierarchy Process (AHP) method is used to evaluate and compare available e-wallets based on criteria that are relevant to students. This method allows students to determine the e-wallet that best suits their needs and priorities. This study shows that AHP is a useful tool to help students choose the right e-wallet.Keyword: e-wallet, management, Analytical Hierarchy Process, priorities
Power Counter-Strategies in Gender Relations
Authors: Ilham EL MAJDOUBI  
Published: June 2024

This article examines the potential of Queer Theory as a theoretical framework for gender relations and an alternative approach to mainstream power dynamics. The counter-discursive strategies under study draw upon the seminal critical contributions of Michel Foucault and his theories of power, Eve K. Sedgwick and her theory of the closet, and Judith Butler and her work on gender and performativity. The study finds that Butler highlights stylization as pervasive in performance. Integrating Sedgwick's queer theory and Foucault’s critical analysis discourse, the study explores how theater challenges conventionality. Sedgwick deepens the understanding of fluid identities, complementing Butler's focus on embodiment. Through interdisciplinary analysis, the study explores the dynamics of power within theatrical representations.
Mosaico de unidades de conservação da Serra da Mantiqueira: configuração atual e desafios futuros
Authors: Peixoto Diogo da Costa , Vargas Karine Bueno 
Published: June 2024

O presente artigo tem por objetivo analisar o modelo de gestão em Mosaico de Unidades de Conservação (MUC), tendo como objeto de estudo o Mosaico Mantiqueira (MUC Mantiqueira), localizado na região sudeste do Brasil. Por meio de um levantamento bibliográfico foi possível estabelecer um histórico da criação desse modelo de gestão. Será apresentado também a composição e organização do MUC Mantiqueira, bem como suas ações e desafios como uma organização de gestão integrada, tendo as atas das reuniões do Conselho Consultivo do MUC Mantiqueira bem como seu Regimento Interno como fonte, além de entrevistas com membros do Conselho Consultivo. Foi verificado que o Mosaico Mantiqueira apresenta baixo grau de implementação, apesar da regularidade nas reuniões do Conselho Consultivo e de atividades desenvolvidas na região do mosaico. Palavras-chave: Mosaico de Unidades de Conservação. MUC Mantiqueira. Gestão Integrada.
СТИЛЬ УПРАВЛІННЯ ЯК ІНТЕГРАТИВНА ХАРАКТЕРИСТИКА ДІЯЛЬНОСТІ КЕРІВНИКА
Authors: Василькевич Я. , Кікінежді О. 
Published: June 2024

У статті проаналізовано теоретичні засади проблеми стилів управління як інтегративної характеристики діяльності керівника. Подано результати емпіричного дослідження особливостей стилю управління за шкалою Ф. Фідлера «Найменш бажаний співробітник» (LPC). Визначено особливості поведінки керівників, ступінь орієнтації на завдання і взаємостосунки, ефективність стилю керівництва у зв’язку з організаційною ситуацією.
An ex vivo method to evaluate vasoactivity induced by hemoglobin-based oxygen carriers in resistance vessels
Authors: Yu Hang , Gao Daoyuan , You Guoxing , Li Weidan , Wang Ying , Chen Yuzhi , Zhao Lian 
Published: June 2024

Red blood cell substitutes offer a solution to the problem of blood shortage and side effects of blood transfusion. Hemoglobin-based oxygen carriers (HBOCs) are one of the promising substitutes for red blood cells. Vasoactivity, which refers to the side effect of HBOCs that causes vasoconstriction and subsequent hypertension, limits the clinical application of HBOCs. In this study, an ex vivo method for the evaluation of vasoactivity induced by HBOCs was established based on isolated rat mesenteric artery vessels and the DMT120CP system. The DMT120CP system, equipped with a flowmeter, permits the control of intravascular pressure, pressure gradient, and flow conditions with high accuracy, simulating the physiological conditions for isolated vessels. The concentration of noradrenaline was optimized to 1 × 10−6∼3 × 10−6 M. PEGylated bovine hemoglobin (PEG-bHb) was synthesized and perfused into the vessel for vasoactivity evaluation, with bHb as the positive control and PSS buffer solution as the negative control. PEG-bHb showed a hydration diameter of 15.5 ± 1.4 nm and a P50 value of 6.99 mmHg. PEG-bHb exhibited a colloid osmotic pressure of 64.1 mmHg and a viscosity of 1.73 cp at 40 mg/mL. The established vasoactivity evaluation method showed significant differences in samples (bHb or PEG-bHb) with different vasoactivity properties. The vasoconstriction percentage induced by PEG-bHb samples synthesized in different batches showed coefficients of variation less than 5%, indicating good applicability and repeatability. The established evaluation method can be applied to study the vasoactivity induction and elimination strategies, promoting the clinical application of HBOCs.
A noval noninvasive targeted therapy for osteosarcoma: the combination of LIFU and ultrasound-magnetic-mediated SPIO/TP53/PLGA nanobubble
Authors: Ren Honglei , Xiang Shanlin , Liu Aiguo , Wang Qian , Zhou Nian , Hu Zhenming 
Published: June 2024

PurposeOsteosarcoma (OS) is the most common type of primary malignant bone tumor. Transducing a functional TP53 gene can effectively inhibit OS cell activity. Poly lactic acid-glycolic acid (PLGA) nanobubbles (NBs) mediated by focused ultrasound (US) can introduce exogenous genes into target cells in animal models, but this technique relies on the passive free diffusion of agents across the body. The inclusion of superparamagnetic iron oxide (SPIO) in microbubbles allows for magnetic-based tissue localization. A low-intensity-focused ultrasound (LIFU) instrument was developed at our institute, and different intensities of LIFU can either disrupt the NBs (RLI-LIFU) or exert cytocidal effects on the target tissues (RHI-LIFU). Based on these data, we performed US-magnetic-mediated TP53-NB destruction and investigated its ability to inhibit OS growth when combined with LIFU both in vitro and in vivo.MethodsSeveral SPIO/TP53/PLGA (STP) NB variants were prepared and characterized. For the in vitro experiments, HOS and MG63 cells were randomly assigned into five treatment groups. Cell proliferation and the expression of TP53 were detected by CCK8, qRT-PCR and Western blotting, respectively. In vivo, tumor-bearing nude mice were randomly assigned into seven treatment groups. The iron distribution of Perls’ Prussian blue-stained tissue sections was determined by optical microscopy. TUNEL-DAPI was performed to examine apoptosis. TP53 expression was detected by qRT-PCR and immunohistochemistry.ResultsSPIO/TP53/PLGA NBs with a particle size of approximately 200 nm were prepared successfully. For in vitro experiments, ultrasound-targeted transfection of TP53 overexpression in OS cells and efficient inhibition of OS proliferation have been demonstrated. Furthermore, in a tumor-bearing nude mouse model, RLI-LIFU-magnetic-mediated SPIO/TP53/PLGA NBs increased the transfection efficiency of the TP53 plasmid, resulting in apoptosis. Adding RHI-LIFU to the treatment regimen significantly increased the apoptosis of OS cells in vivo.ConclusionCombining LIFU and US-magnetic-mediated SPIO/TP53/PLGA NB destruction is potentially a novel noninvasive and targeted therapy for OS.
Molecular characterization of vaginal microbiota using a new 22-species qRT-PCR test to achieve a relative-abundance and species-based diagnosis of bacterial vaginosis
Authors: Oyenihi Ayodeji B. , Haines Ronald , Trama Jason , Faro Sebastian , Mordechai Eli , Adelson Martin E. , Osei Sekyere John 
Published: June 2024

BackgroundNumerous bacteria are involved in the etiology of bacterial vaginosis (BV). Yet, current tests only focus on a select few. We therefore designed a new test targeting 22 BV-relevant species.MethodsUsing 946 stored vaginal samples, a new qPCR test that quantitatively identifies 22 bacterial species was designed. The distribution and relative abundance of each species, α- and β-diversities, correlation, and species co-existence were determined per sample. A diagnostic index was modeled from the data, trained, and tested to classify samples into BV-positive, BV-negative, or transitional BV.ResultsThe qPCR test identified all 22 targeted species with 95 – 100% sensitivity and specificity within 8 hours (from sample reception). Across most samples, Lactobacillus iners, Lactobacillus crispatus, Lactobacillus jensenii, Gardnerella vaginalis, Fannyhessea (Atopobium) vaginae, Prevotella bivia, and Megasphaera sp. type 1 were relatively abundant. BVAB-1 was more abundant and distributed than BVAB-2 and BVAB-3. No Mycoplasma genitalium was found. The inter-sample similarity was very low, and correlations existed between key species, which were used to model, train, and test a diagnostic index: MDL-BV index. The MDL-BV index, using both species and relative abundance markers, classified samples into three vaginal microbiome states. Testing this index on our samples, 491 were BV-positive, 318 were BV-negative, and 137 were transitional BV. Although important differences in BV status were observed between different age groups, races, and pregnancy status, they were statistically insignificant.ConclusionUsing a diverse and large number of vaginal samples from different races and age groups, including pregnant women, the new qRT-PCR test and MDL-BV index efficiently diagnosed BV within 8 hours (from sample reception), using 22 BV-associated species.
Individualized luteal phase support in frozen-thawed embryo transfer after intramuscular progesterone administration might rectify live birth rate
Authors: Boynukalin Fazilet Kübra , Tohma Yusuf Aytac , Yarkıner Zalihe , Gultomruk Meral , Bozdag Gürkan , Ozkavukcu Sinan , Bahçeci Mustafa , Demir Berfu 
Published: June 2024

BackgroundThe serum P concentrations are suggested to have an impact on pregnancy outcome. However there is no consensus about the optimal progesterone cut-off during the luteal phase. Few studies evaluated the effectiveness of a “rescue protocol” for low serum P concentrations and most of these studies used vaginal progesterone administration. There is paucity of data on the effectiveness of rescue protocol using intramuscular progesterone (IM-P) in frozen-thawed embryo transfer (FET).MethodsThis study is a retrospective cohort study included 637 single or double blastocyst FETs with artificially prepared endometrium receiving 100 mg IM progesterone (P) after incremental estrogen treatment. Serum P concentrations were evaluated using blood samples obtained 117-119 hours after the first IM-P administration and 21 ± 2 hours after the last IM-P administration. Patients with serum P concentrations &lt;20.6 ng/ml on the ET day were administrated 400 mg vaginal progesterone for rescue.ResultsDemographic and cycle characteristics were similar between patients receiving rescue vaginal P (embryo transfer (ET)-day P concentration &lt; 20.6 ng/ml) and patients who did not need rescue vaginal P (ET-day P concentration ≥ 20.6 ng/ml). Clinical pregnancy, miscarriage, and live birth rates were similar between two groups: 52.9%(45/85) vs 59.6%(326/552), p=0.287; 11.1%(5/45) vs 14.1%(46/326), p=0.583; and 47.1%(40/85) vs 50.7%(280/552), p=0.526, respectively. Logistic regression analysis revealed that the female age (p = 0.008, OR=0.942, 95% CI = 0.902–0.984) and embryo quality (ref: good quality for moderate: p=0.02, OR=0.469, 95% CI =0.269–0.760; for poor: p=0.013, OR= 0.269, 95% CI = 0.092–0.757) were independent variables for live birth. Following rescue protocol implementation, ET-day P concentration was not a significant predictor of live birth.ConclusionsRescue vaginal P administration for low ET day serum P concentrations following IM-P yields comparable live birth rates.
Integrating machine learning algorithms and multiple immunohistochemistry validation to unveil novel diagnostic markers based on costimulatory molecules for predicting immune microenvironment status in triple-negative breast cancer
Authors: Zhang Chao , Zhai Wenyu , Ma Yuyu , Wu Minqing , Cai Qiaoting , Huang Jiajia , Zhou Zhihuan , Duan Fangfang 
Published: June 2024

IntroductionCostimulatory molecules are putative novel targets or potential additions to current available immunotherapy, but their expression patterns and clinical value in triple-negative breast cancer (TNBC) are to be clarified. MethodsThe gene expression profiles datasets of TNBC patients were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus databases. Diagnostic biomarkers for stratifying individualized tumor immune microenvironment (TIME) were identified using the Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine-Recursive Feature Elimination (SVM-RFE) algorithms. Additionally, we explored their associations with response to immunotherapy via the multiplex immunohistochemistry (mIHC). ResultsA total of 60 costimulatory molecule genes (CMGs) were obtained, and we determined two different TIME subclasses (“hot” and “cold”) through the K-means clustering method. The “hot” tumors presented a higher infiltration of activated immune cells, i.e., CD4 memory-activated T cells, resting NK cells, M1 macrophages, and CD8 T cells, thereby enriched in the B cell and T cell receptor signaling pathways. LASSO and SVM-RFE algorithms identified three CMGs (CD86, TNFRSF17 and TNFRSF1B) as diagnostic biomarkers. Following, a novel diagnostic nomogram was constructed for predicting individualized TIME status and was validated with good predictive accuracy in TCGA, GSE76250 and GSE58812 databases. Further mIHC conformed that TNBC patients with high CD86, TNFRSF17 and TNFRSF1B levels tended to respond to immunotherapy. ConclusionThis study supplemented evidence about the value of CMGs in TNBC. In addition, CD86, TNFRSF17 and TNFRSF1B were found as potential biomarkers, significantly promoting TNBC patient selection for immunotherapeutic guidance.