bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgeon- and hospital-level variation in wait times for scheduled non-urgent surgery in Ontario, Canada: A cross-sectional population-based study
Authors: de Jager Pieter , Aleman Dionne , Baxter Nancy , Bell Chaim , Bodur Merve , Calzavara Andrew , Campbell Robert , Carter Michael , Emerson Scott , Gagliardi Anna , Irish Jonathan , Martin Danielle , Lee Samantha , SaxeBraithwaite Marcy , Seyedi Pardis , Takata Julie , Yang Suting , Zanchetta Claudia , Urbach David R. 
Published: August 2024

Background
Canadian health systems fare poorly in providing timely access to elective surgical care, which is crucial for quality, trust, and satisfaction.

Methods
We conducted a cross-sectional analysis of surgical wait times for adults receiving non-urgent cataract surgery, knee arthroplasty, hip arthroplasty, gallbladder surgery, and non-cancer uterine surgery in Ontario, Canada, between 2013 and 2019. We obtained data from the Wait Times Information System (WTIS) database. Inter- and intra-hospital and surgeon variations in wait time were described graphically with caterpillar plots. We used non-nested 3-level hierarchical random effects models to estimate variation partition coefficients, quantifying the proportion of wait time variance attributable to surgeons and hospitals.

Results
A total of 942,605 procedures at 107 healthcare facilities, conducted by 1,834 surgeons, were included in the analysis. We observed significant intra- and inter-provider variations in wait times across all five surgical procedures. Inter-facility median wait time varied between six-fold for gallbladder surgery and 15-fold for knee arthroplasty. Inter-surgeon variation was more pronounced, ranging from a 17-fold median wait time difference for cataract surgery to a 216-fold difference for non-cancer uterine surgery. The proportion of variation in wait times attributable to facilities ranged from 6.2% for gallbladder surgery to 23.0% for cataract surgery. In comparison, surgeon-related variation ranged from 16.0% for non-cancer uterine surgery to 28.0% for cataract surgery.

Implications
There is extreme variability in surgical wait times for five common, high-volume, non-urgent surgical procedures. Strategies to address surgical wait times must address the variation between service providers through better coordination of supply and demand. Approaches such as single-entry models could improve surgical system performance.
Adherence to antiretroviral therapy among cisgender gay, bisexual and other men who have sex with men in Brazil: Evaluating the role of HIV-related stigma dimensions
Authors: Matos Victor C. , Torres Thiago S. , Luz Paula M. 
Published: August 2024

Background
In Brazil, ~35% of people living with HIV (PLHIV) have poor adherence to antiretroviral therapy (ART). HIV-related stigma is associated with worst continuum of care outcomes, however evidence from Brazil is scarce. We explored pathways between HIV-related stigma dimensions and ART adherence among Brazilian cisgender gay, bisexual and other men who have sex with men (MSM) living with HIV.

Methods
A sample of MSM ≥18 years was recruited online between February/March 2020 through advertisements on Hornet, a location-based dating app. Validated scales were used to assess ART adherence and HIV-related stigma. Indirect and direct pathways between HIV-related stigma dimensions and ART adherence were estimated using structural equation models while considering socio-demographic and substance use related variables. Models were estimated using mean- and variance-adjusted weighted least squares, and goodness of fit indices were calculated.

Findings
Among 1,719 MSM living with HIV who reported starting ART, 70% were adherent. There was evidence of indirect effects of concerns about public attitudes (standardized coefficient (SC) = -0.095, 95% confidence interval (95%CI) = -0.172 - -0.017) and personalized HIV-stigma (SC = -0.022, 95%CI = -0.043 - -0.001) on ART adherence mediated through negative self-image. Personalized HIV stigma and concerns about public attitudes were both positively associated with negative self-image (SC = 0.129, 95%CI = 0.066–0.193; SC = 0.549, 95%CI = 0.494–0.603), and concerns about public attitudes was associated with HIV disclosure concerns (SC = 0.522, 95%CI = 0.463–0.581). However, the direct paths from personalized HIV stigma and concerns about public attitudes to ART adherence were not significant.

Interpretation
Our research underscores the critical need for multifaceted interventions to eliminate HIV-related stigma at both individual and societal levels. At the individual level, psychotherapeutic interventions to improve self-image might helpful. Additionally, public policy should aim to dismantle structural stigma with awareness campaigns on various media channels, integration of anti-stigma curriculum into schools, and training for professionals.
Cross-cultural adaptation and reliability of the European Portuguese version of the Musculoskeletal Health Questionnaire: A methodological study
Authors: Ribeiro Hermínia , Cruz Eduardo Brazete , Castro Ana , Rodrigues Ana , Heleno Bruno , Dias Teresa L. , Pires Diogo 
Published: August 2024

Purpose
To culturally adapt the Musculoskeletal Health Questionnaire (MSK-HQ) to European Portuguese and evaluate its reliability in individuals with musculoskeletal conditions.

Materials and methods
The study was carried out in two phases. In the first phase, the MSK-HQ was translated and culturally adapted. In the second phase, a longitudinal observational study was carried out with a convenience sample of participants with musculoskeletal conditions. Data collection began at the start of physiotherapy treatments by filling in the MSK-HQ and Numeric Pain Rating Scale (NPRS). After 4–7 days, the participants were asked to fill out the MSK-HQ once again, as well as the Patient Global Improvement Change (PGIC) scale. The data collected was used to study internal consistency, test-retest reliability, and measurement error. Floor and ceiling effects were also analysed.

Results
The MSK-HQ was successfully translated and adapted into European Portuguese. The second phase of the study had a sample of 191 participants. This study demonstrated high internal consistency (Cronbach’s α = 0.885) and excellent test-retest reliability (ICC(2,1) = 0.908). The analysis of measurement error resulted in an SEM of 2.818 and an SDC at 7.811. No floor or ceiling effect was observed.

Conclusions
The MSK-HQ-PT is a reliable instrument for measuring musculoskeletal health. Further studies on its validity and responsiveness are needed.
HIV transcription persists in the brain of virally suppressed people with HIV
Authors: Jamal Eddine Janna , Angelovich Thomas A. , Zhou Jingling , Byrnes Sarah J. , Tumpach Carolin , Saraya Nadia , Chalmers Emily , Shepherd Rory A. , Tan Abigail , Marinis Stephanie , Gorry Paul R. , Estes Jacob D. , Brew Bruce J. , Lewin Sharon R. , Telwatte Sushama , Roche Michael , Churchill Melissa J. 
Published: August 2024

HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression with antiretroviral therapy (ART) and is subject to the same blocks to transcription seen in other tissues and blood, is unclear. Here, we quantified the level of HIV transcripts in frontal cortex tissue from virally suppressed or non-virally suppressed people with HIV (PWH).
HIV transcriptional profiling of frontal cortex brain tissue (and PBMCs where available) from virally suppressed (n = 11) and non-virally suppressed PWH (n = 13) was performed using digital polymerase chain reaction assays (dPCR). CD68+ myeloid cells or CD3+ T cells expressing HIV p24 protein present in frontal cortex tissue was detected using multiplex immunofluorescence imaging.
Frontal cortex brain tissue from PWH had HIV TAR (n = 23/24) and Long-LTR (n = 20/24) transcripts. Completion of HIV transcription was evident in brain tissue from 12/13 non-virally suppressed PWH and from 5/11 virally suppressed PWH, with HIV p24+CD68+ cells detected in these individuals. While a block to proximal elongation was present in frontal cortex tissue from both PWH groups, this block was more extensive in virally suppressed PWH.
These findings suggest that the brain is a transcriptionally active HIV reservoir in a subset of virally suppressed PWH.
Analysis of the experience with once-weekly intramuscular administration of interferon beta-1a in the Russian population of patients with relapsing-remitting multiple sclerosis
Authors: Khabirov F. A. , Granatov E. V. , Dykhanov A. Ya. , Khaibullin T. I. 
Published: August 2024

SinnoVex is a drug from the group of bioanalogues of interferon beta-1a for intramuscular administration, which has moderate efficacy in reducing clinical exacerbations of multiple sclerosis (MS), which is most pronounced in the initial treatment of relapsing-remitting MS (RRMS) with low or moderate disease activity.Objective: to analyze the experience with the use of the drug SinnoVex in several parallel studies in the Russian population of patients with RRMS.Material and methods. We analyzed the results of three retrospective post-marketing clinical trials, in which we compared the efficacy and safety of the use of interferon beta-1a for once-weekly intramuscular administration under the trade name SinnoVex in the treatment of the Russian population of patients with RRMS with other MS disease-modifying treatments (DMTs), in particular with high-dose interferons beta-1a and interferons beta-1b for subcutaneous administration. The total number of patients who received therapy with SinnoVex was 235 subjects. The efficacy of the therapy was assessed using the following indicators: average annual frequency of exacerbations, MRI activity, achievement of the NEDA-3 indicator. The safety of the therapy was evaluated based on the occurrence of adverse events (AEs) and their severity as well as the frequency of discontinuation of the drug.Results. Based on the results of the studies presented, no statistically significant differences in the clinical efficacy or tolerability of the intramuscularly administered SinnoVex preparation compared to other drugs of the interferon beta group were found. The spectrum and severity of AEs were in line with expectations; no unexpected AEs were observed.Conclusion. Among the important advantages of the drug are the relatively rare intramuscular injections and rare local skin AEs after injections, which significantly increase the benefit of the drug in young patients. In this regard, SinnoVex is most commonly used as an initial drug as part of an escalation approach to the treatment of RRMS and then needs to be replaced by more highly effective firstor second-line DMTs if efficacy is insufficient.
Global transcriptome profiling of blood mononuclear cells from individuals with radiologically isolated syndrome reveals abnormalities characteristic of the rapid manifestation of multiple sclerosis symptoms
Authors: Kozin M. S. , Kabaeva A. R. , Omarova M. A. , Boyko A. N. , Favorova O. O. , Kulakova O. G. 
Published: August 2024

Objective: to look for differences in the transcriptome profiles in mononuclear blood cells of a group of patients with radiologically isolated syndrome (RIS) who developed symptoms of multiple sclerosis (MS) in the following three years of observation and a group of patients with RIS who did not develop MS during this period.Material and methods. The study included 19 patients with RIS (9 men and 10 women), six of whom developed symptoms of MS during the three-year follow-up period. The transcription profiles of blood mononuclear cells were compared between the groups of patients with RIS who developed or did not develop MS symptoms during this period. The work was conducted in the format of a prospective study; the time of blood collection was taken as the reference point. Full transcriptome profiling was performed using RNA sequencing on an MGISEQ-200 platform. Differential gene expression analysis was performed using the DESeq2 package for the R programming language. Subsequent analysis involved constructing a network of interactions between the protein products of the detected differentially expressed genes based on data from the STRING database, identifying a cluster of interacting proteins, and analyzing the enrichment of this cluster by participants in pathways annotated in the KEGG database.Results. The expression of 146 genes differed significantly (p<0.05; |log2FC| >1) in the studied groups of patients with RIS: in patients with subsequent manifestation of MS symptoms, the expression of 67 genes was lower and expression of 79 genes was higher than in patients without MS symptoms. The decrease in expression of two of the 67 genes (ADGRG7 and LGALS9C) remained significant even after correction for multiple comparisons (padj=2.17⋅10-11 and padj=6.19⋅10-6, respectively). Analyzing the network of interactions between the protein products of the differentially expressed genes allowed the identification of a cluster of 12 genes: APBB2, CCL4, CCL4L2, CDH2, DAZL, FOSB, H2BC17, JUN, KLF4, KLF5, MAPK8IP1, SYCE1; it is over-represented by components of the Toll-like receptor signaling pathway.Conclusion. The transcriptome profiles of blood mononuclear cells differ in groups of patients with RIS who did or did not develop MS symptoms during the three-year follow-up period. The decrease in the expression level of ADGRG7 and LGALS9C genes detected in this study as a sign of rapid conversion of RIS to MS needs to be confirmed in independent samples.
Listing all delta partitions of a given set: Algorithm design and results
Authors: Nofal Samer 
Published: August 2024

Abstract
Let

α

\alpha

be a set of

n

n

elements and

δ

\delta

be a nonnegative integer. A

δ

\delta

-partition of

α

\alpha

is a set of pairwise disjoint nonempty subsets of

α

\alpha

such that the union of the subsets is equal to

α

\alpha

and every subset has a size greater than

δ

\delta

. We formulate an algorithm for computing all

δ

\delta

-partitions of a given

n

n

-element set and show that the algorithm runs in

O

(

n

)

{\mathcal{O}}\left(n)

space and

O

(

n

)

{\mathcal{O}}\left(n)

delay time between any two successive outputs of

δ

\delta

-partitions of the given set. An application of the notion of

δ

\delta

-partitions is illustrated in the following scheduling problem. Suppose a factory has

n

n

machines and

m
≤
n

m\le n

jobs to complete daily. Every job can be accomplished by operating at least

δ
+
1

\delta +1

machines. A machine cannot work on multiple jobs simultaneously. According to a utilization policy of the factory’s management, no machine is allowed to be idle, so all machines should be running on some job. Find a daily schedule of the factory’s machines satisfying all the mentioned constraints. Let

α

\alpha

be the set of the factory’s machines. Then, an

α

\alpha

’s

δ

\delta

-partition with

m

m

subsets is a legal schedule if every subset (in the

δ

\delta

-partition) includes exclusively

δ
+
1

\delta +1

or more machines that run on the same job.
Enhancing the performance of a additive manufactured battery holder using a coupled artificial neural network with a hybrid flood algorithm and water wave algorithm
Authors: Yildiz Betül Sultan 
Published: August 2024

Abstract
This research is the first attempt in the literature to combine design for additive manufacturing and hybrid flood algorithms for the optimal design of battery holders of an electric vehicle. This article uses a recent metaheuristic to explore the optimization of a battery holder for an electric vehicle. A polylactic acid (PLA) material is preferred during the design of the holder for additive manufacturing. Specifically, both a hybrid flood algorithm (FLA-SA) and a water wave optimizer (WWO) are utilized to generate an optimal design for the holder. The flood algorithm is hybridized with a simulated annealing algorithm. An artificial neural network is employed to acquire a meta-model, enhancing optimization efficiency. The results underscore the robustness of the hybrid flood algorithm in achieving optimal designs for electric car components, suggesting its potential applicability in various product development processes.
The crystal structure of trichlorobis(pyridine-2,6-dithio-κS-carbomethylamido)antimony(III), [SbCl3(C9H11N3S2)2]
Authors: Herbig Marcus , Böhme Uwe 
Published: August 2024

Abstract
[SbCl3(C9H11N3S2)2], monoclinic, P21/n (no. 14), a = 13.8069(4) Å, b = 13.5739(6) Å, c = 14.0182(5) Å, β = 94.231(3)°, V = 2,620.04(17) Å3, Z = 4, R

gt
(F) = 0.0329, wRref
(F
2) = 0.0726, T = 153 K.
Which Global Cycle? A Stochastic Factor Selection Approach for Global Macro-Financial Cycles
Authors: Berger Tino , Hienzsch Sebastian 
Published: August 2024

Abstract
Instead of assuming a certain factor structure, we statistically test for the factor structure driving common global dynamics in macroeconomic and financial data by employing a stochastic factor selection approach. Using a sample of 16 developed countries from 1996Q1 to 2019Q4, we present strong empirical evidence of a global macro-financial cycle and an independent global financial cycle. Moreover, the global macro-financial cycle we estimate is essentially the global business cycle identified in the literature. It captures the common global macroeconomic dynamics and drives a significant share of the comovement in the financial sector. The remaining commonality in financial variables is driven by separate global financial cycles: the global credit cycle and the global capital flow cycle.
Determination of the Number of Breaks in Heterogeneous Panel Data Models
Authors: Wang Lu , Hu Shuke 
Published: August 2024

Abstract
This paper considers a heterogeneous panel data model with an unknown number of breaks. We propose a so-called two-stage procedure to determine the number of breaks and detect the location of break points. The consistency of the estimated number of breaks and the estimated break points are established under fairly general conditions. Monte Carlo simulations and two empirical applications are provided to demonstrate the finite sample performance of the proposed method.
Taxonomic review of the genus Hampsonidia Inoue, 1958 (Lepidoptera: Noctuidae: Acronictinae) with describing two new species from China
Authors: Kiss Ádám 
Published: August 2024

AbstractThe genus Hampsonidia Inoue, 1958 (objective replacement name for Hampsonia Kozhanchikov, 1950) was revised. Two new species are described from China: H. georgii Kiss sp. n. and H. rocinante Kiss & H.-L. Han sp. n. All species of the genus are illustrated by colour photos of adults and black-and-white genitalia photos, and in two species, both male and female last abdominal segments are illustrated. The male last abdominal segments of Herzinycta albonigra (Herz, 1904) and the female last abdominal segments of Draudtinycta tigniumbra (Draudt, 1937) are illustrated and described for the first time.
Enhancing Onion Cultivation in Indonesia: AMOS Analysis of Technology Adoption in South Sulawesi and East Java
Authors: . Zulkifli , Bulkis S. , Fahmid I.M. , . Rahmadanih 
Published: August 2024

Background: The adoption of agricultural technology contributes a vital role in increasing the use and profitability of agricultural resources.Strategic commodities, such as onions, should receive special attention in technology development to increase production to support the Indonesian economy. This study aimed to analyze the effectiveness of using AMOS in discussing technology adoption in onion cultivation. Methods: The research method was carried out using the Structural Equation Modeling (SEM) approach, with the solution using the Analysis of Moment Structures (AMOS).The research was conducted in the Provinces of South Sulawesi and East Java, focusing on Enrekang Regency, South Sulawesi Province and Nganjuk Regency, East Java Province, each covering two sub-districts, resulting in a total of four sub-districts. Result: The results showed that onion farmers in South Sulawesi and East Java were relatively more adaptive to adopting agricultural technology, as indicated by the hypothesis testing results.The CR values for H1 was 0.043 and H2 -0.041.
Implementasi Pendidikan Akhlak Melalui Metode Storytelling Interaktif Pada Anak Usia Dini
Authors: Afifah Nurul Hidhayah  , Nur Tanfidiyah  
Published: August 2024

Berdasarkan hal ini, tujuan dari penelitian ini untuk mengetahui bagaimana implementasi pendidikan akhlak melalui metode storytelling interaktif pada anak usia dini di TKIT Mutiara Insan Sukoharjo tahun ajaran 2023. Jenis penelitian yang digunakan adalah penelitian deskriptif kualitatif. Teknik pengumpulan data menggunakan metode observasi partisipatif, wawancara semi terstruktur dan dokumentasi. Teknik keabsahan data menggunakan triangulasi teknik dan sumber, sedangkan untuk teknik analisis data menggunakan langkah pengumpulan data,komdensasi data, penyajian data dan kesimpulan.
Hasil penelitian yaitu, penggunaan metode storytelling interaktif dalam menguatkan pendidikan akhlak di TKIT Mutiara Insan dilakukan dengan tahap perencanaan pembelajaran, pelaksanaan pembelajaran dan evaluasi. Pada tahap perencanaan guru menyusun RPPH, tahap pelaksanaan guru melakukan 3 langkah: pembukaan guru menyampaikan salam dan menyampaikan materi, kegiatan inti guru bercerita dengan tema yang sesuai dengan kurikulum, tanya jawab, menyampaikan pesan-pesan, penutup guru melakukan recalling terhadap apa saja yang sudah dipelajari. Pada tahap evaluasi dilakukan pada setiap hari pada akhir pembelajaran dengan menggunakan penilaian cheklist dan anekdot
PEDAGOGIA QUILOMBOLA
Authors: Aviz Roselete , Hartmann Luciana 
Published: August 2024

A pesquisa em que este trabalho baseia-se visa a conhecer a vida, a cultura e as relações entre crianças e idosos da Comunidade Quilombola Ribeirão do Cubatão (SC). Assim, este artigo traz algumas reflexões sobre as contribuições metodológicas dessa investigação, cuja base é a Pedagogia Quilombola: compartilhamento de vidas, trocas de experiências, saberes e práticas entre idosos, crianças e adolescentes de modo coletivo e relacional. Versa sobre o que denominamos como Oficinas Narrativas e sua organização. O foco é a autoria/participação das crianças e idosos na produção de narrativas em diferentes linguagens (orais, escritas, visuais e/ou audiovisuais), dialogando tanto com a presença da cultura das mídias no cotidiano infantil como com as referências tradicionais de cada contexto cultural. Como resultados parciais, compreende-se que essa metodologia, além de promover a possibilidade do diálogo, pode proporcionar a co-produção de dados, por parte das crianças e dos idosos, durante as investigações realizadas com eles.