bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Patients with IgA Nephropathy: Evaluation of the Safety and Efficacy of Mycophenolate Mofetil
Authors: Chen Zaobin , Chen Wenmin , Zheng Lingqian , Xie Yina , Yao Kaijin , Zhou Tianbiao 
Published: July 2024

Introduction and Aim:
Immunoglobulin A nephropathy (IgAN), characterized by aberrant IgA immune
complex deposition, is the most prevalent primary glomerular disease and the main cause of end-stage renal
disease, causing a significant physical and psychological burden on people worldwide. Conventional therapeutic
approaches, such as renin-angiotensin-aldosterone system inhibitors and corticosteroids, may not
achieve sufficient effectiveness and may produce major side events in the past. The previous data in Asian populations
indicated that mycophenolate mofetil (MMF) might significantly advance the development of a new
therapy strategy for IgAN. The effectiveness and safety of MMF in patients with IgAN will be investigated in
this study.

Methods:
A literature search was conducted on June 30th, 2023, by searching the following databases: PubMed
and the Cochrane Library according to predefined criteria. To investigate the renoprotective benefits and safety
of MMF, statistical analyses were performed using Cochrane’s Review Manager Version 5.3.

Results:
The meta-analysis included nine randomized controlled studies that fulfilled the inclusion criterion.
In the Asian population, the results revealed a substantial difference in remission rates between the MMF
group and the control group (OR: 2.53, 95% CI: 1.02, 6.30, P = 0.05). MMF can increase the rate of decrease
in proteinuria in IgAN patients when compared with controls in Asians (OR: 7.34, 95% CI: 2.69, 20.08, P =
0.0001), and MMF can reduce the urinary protein in patients with IgAN in Asians (WMD: -0.61, 95% CI:
-1.15, -0.08, P = 0.02). Interestingly, these studies on Asians were conducted in China. However, the differences
in remission rate, rate of decrease in proteinuria, and urinary protein reduction between the MMF group
and control group were not found in overall populations and in the Caucasian population. The differences in
complete remission rate, partial remission rate, serum creatinine (SCr) doubling rate, rate of 50% increase in
SCr, and rate of need for renal replacement treatment between the MMF group and control group were not
found in Asians, Caucasians, and overall populations. The difference in the rate of side effects between the
MMF group and the control group was not found.

Conclusion:
MMF protects renal function and is a safe medication for treating Chinese IgAN patients. MMF
might significantly advance the development of a new therapy strategy for IgAN in the Chinese population.
Melocular Evolution on Cold Temperature Adaptation of Chinese Rhesus Macaques
Authors: Wang Xuan , Feng Ming-Hong , Wang Shao-Bo , Shi Hong 
Published: July 2024

Introduction:
Currently, macaques are used as animal models for human disease in
biomedical research. There are two macaques species widely used as animal models, i.e., cynomolgus
macaques and rhesus macaques. These two primates distribute widely, and their natural habitats
are different. Cynomolgus macaques distribute in tropical climates, while rhesus macaques
mostly distribute in relatively cold environments, and cynomolgus macaques have a common frostbite
problem during winter when they are transferred to cold environments.

Methods:
In order to explore the molecular mechanisms underlying the temperature adaptation in
macaques, genetic analysis and natural selection tests were performed. Based on the analysis of
heat shock protein genes, DNAJC22, DNAJC28, and HSF5 showed positive selection signals. To
these 3 genes, the significantly differential expression had been confirmed between cynomolgus
macaques and Chinese rhesus macaques.

Results:
Molecular evolution analysis showed that mutations of DNAJC22, DNAJC28, and HSF5
in Chinese rhesus macaques could enable them to gain the ability to rapidly regulate body temperature.
The heat shock proteins provided an important function for Chinese rhesus macaques, allowing
them to adapt to a wide range of temperatures and spread widely. The selection time that was
estimated suggested that the cold adaptation of Chinese rhesus macaques coincided with the time
that the modern human populations migrated northward from tropic regions to relatively cold regions,
and the selection genes were similar.

Conclusion:
This study elucidated the evolutionary history of cynomolgus macaques and rhesus
macaques from molecular adaptation. Furthermore, it provided an evolutionary perspective to reveal
the different distribution and adaptation of macaques. Cynomolgus macaques is an ideal
biomedical animal model to mimic human natural frostbite.
Quercetin in Oncology: A Phytochemical with Immense Therapeutic Potential
Authors: Kamal Raj , Paul Priyanka , Thakur Shubham , Singh Sachin Kumar , Awasthi Ankit 
Published: July 2024

:
Quercetin is a natural flavonoid with various pharmacological actions such as anti-inflammatory,
antioxidant, antimicrobial, anticancer, antiviral, antidiabetic, cardioprotective, neuroprotective,
and antiviral activities. Looking at these enormous potentials, researchers have explored
how they can be used to manage numerous cancers. It's been studied for cancer management
due to its anti-angiogenesis, anti-metastatic, and antiproliferative mechanisms. Despite having
these proven pharmacological activities, the clinical use of quercetin is limited due to its first--
pass metabolism, poor solubility, and bioavailability. To address these shortcomings, researchers
have fabricated various nanocarriers-based formulations to fight cancer. The present review overshadows
the pharmacological potential, mechanisms, and application of nanoformulations against
different cancers.

Teaser:
Explore the potential of Quercetin, a natural flavonoid with diverse pharmacological activities,
and its nanoformulations in managing various cancers.
Safety of Mechanical Thrombectomy for Acute Ischemic Stroke in Patients with Thrombocytopenia
Authors: Zheng Sujie , Liu Fang , Yu Liang , Jiang Xinzhao , Wen Xiaoyan , Wang Xu , Shi Zongjie 
Published: July 2024

Background and Aim:
The impact of low platelet count on outcomes in patients with
Acute Ischemic Stroke (AIS) undergoing Mechanical Thrombectomy (MT) is still unclear. In this
study we have further explored the effect of thrombocytopenia on the safety and efficacy of MT in
patients with anterior circulation Large Vessel Occlusion (LVO) stroke.

Materials and Methods:
Patients with AIS who underwent MT at our center between June 2015
and November 2021 were examined. Based on the platelet count recorded on admission patients
were divided into two groups: those with thrombocytopenia (<150 × 109/L) and those without
thrombocytopenia (≥ 150 × 109/L). Symptomatic Intracranial Hemorrhage (sICH) was the primary safety outcome. The efficacy outcome was functional independence defined as a 90-day
modified Rankin Scale (mRS) score of 0-2. Multivariate logistic regression models were used to
determine the risk factors for post-procedure sICH and 90-day functional outcomes.

Results:
Among 302 patients included in the study, thrombocytopenia was detected in 111
(36.8%) cases. Univariate analysis showed age, the proportion of atrial fibrillation, the rates of
sICH, 90-day poor outcomes, and mortality to be higher in patients with thrombocytopenia (all p
<0.05). Multivariable analysis showed thrombocytopenia to be independently associated with a
higher rate of sICH (OR 2.022, 95% CI 1.074-3.807, p =0.029) however, thrombocytopenia did
not affect the 90-day functional outcomes (OR 1.045, 95%CI 0.490-2.230, p =0.909) and mortality (OR 1.389, 95% CI 0.467– 4.130 p = 0.554).

Conclusion:
Thrombocytopenia may increase the risk of sICH but not affect the 90-day functional
outcomes and mortality in patients with AIS treated with MT.
A Comprehensive Review of Promising Phytoconstituents as Anti-Cancer Agents: Biological Mechanisms and Applications Across Different Cancers
Authors: Elsayed Laila A. , Saif Abdullah M. , Elghol Shrouk E. , Zayed Maha N. , Amin Yomna M. , Omran Mohamed H. , Ragab Mahmoud A. , Althobiti Randa A. , Ali Gomaa A.M. 
Published: July 2024

:
Cancer, claiming approximately 10 million lives annually, remains a leading cause of
global mortality. Conventional cancer treatments, notably chemotherapy and radiotherapy, often
entail adverse effects, such as cytotoxicity and the development of resistance, posing significant
challenges in cancer management. While natural products have historically served medicinal
purposes for various ailments, their recent prominence in combating cancer-related manifestations
has surged. Utilizing natural products either alone as antineoplastic agents or in conjunction
with conventional chemotherapies presents a promising approach to mitigate these adverse
effects. The appeal of natural products lies in their accessibility, versatility, reduced cytotoxic
potential, and capacity to counteract drug resistance. Various natural sources offer a diverse
range of bioactive compounds capable of influencing various cancer types, modulating signaling
pathways, and altering the cancer microenvironment. Notably, many bioactive compounds impact
crucial cellular processes like metastasis, angiogenesis, metabolism, proliferation, and viability
by targeting specific signaling pathways, particularly those involved in cellular apoptosis.

:
Consequently, the modulation of these factors by natural products significantly affects cancer
cell behavior. This comprehensive review explores the application of the promising phytoconstituents
as anti-cancer agents across prevalent cancer types, including liver, lung, bladder,
breast, leukemia, and colon cancer. In addition, it explores the anti-cancer properties of natural
compounds, focusing on their mechanisms and effectiveness against diverse cancers, aiming to
improve cancer management.
Natural Compounds as Protease Inhibitors in Therapeutic Focus on Cancer Therapy
Authors: Kakali Bhadra 
Published: July 2024

:
Proteases are implicated in every hallmark of cancer and have complicated functions. For cancer cells
to survive and thrive, the process of controlling intracellular proteins to keep the balance of the cell proteome is
essential. Numerous natural compounds have been used as ligands/ small molecules to target various proteases
that are found in the lysosomes, mitochondria, cytoplasm, and extracellular matrix, as possible anticancer therapeutics.
Promising protease modulators have been developed for new drug discovery technology through recent
breakthroughs in structural and chemical biology. The protein structure, function of significant tumor-related
proteases, and their natural compound inhibitors have been briefly included in this study. This review highlights
the most current frontiers and future perspectives for novel therapeutic approaches associated with the list of
anticancer natural compounds targeting protease and the mode and mechanism of proteinase-mediated molecular
pathways in cancer.
Integrating Health and Disability Data Into Academic Information Systems: Workflow Optimization Study
Authors: Jabour Abdulrahman 
Published: July 2024

Abstract

Background
Integrating health information into university information systems holds significant potential for enhancing student support and well-being. Despite the growing body of research highlighting issues faced by university students, including stress, depression, and disability, little has been done in the informatics field to incorporate health technologies at the institutional level.

Objective
This study aims to investigate the current state of health information integration within university systems and provide design recommendations to address existing gaps and opportunities.

Methods
We used a user-centered approach to conduct interviews and focus group sessions with stakeholders to gather comprehensive insights and requirements for the system. The methodology involved data collection, analysis, and the development of a suggested workflow.

Results
The findings of this study revealed the shortcomings in the current process of handling health and disability data within university information systems. In our results, we discuss some requirements identified for integrating health-related information into student information systems, such as privacy and confidentiality, timely communication, task automation, and disability resources. We propose a workflow that separates the process into 2 distinct components: a health and disability system and measures of quality of life and wellness. The proposed workflow highlights the vital role of academic advisors in facilitating support and enhancing coordination among stakeholders.

Conclusions
To streamline the workflow, it is vital to have effective coordination among stakeholders and redesign the university information system. However, implementing the new system will require significant capital and resources. We strongly emphasize the importance of increased standardization and regulation to support the information system requirements for health and disability. Through the adoption of standardized practices and regulations, we can ensure the smooth and effective implementation of the required support system.
User Requirements for an Electronic Patient Recruitment System: Semistructured Interview Analysis After First Implementation in 3 German University Hospitals
Authors: Stein Alexandra , Blasini Romina , Strantz Cosima , Fitzer Kai , Gulden Christian , Leddig Torsten , Hoffmann Wolfgang 
Published: July 2024

Background
Clinical trials are essential for medical research and medical progress. Nevertheless, trials often fail to reach their recruitment goals. Patient recruitment systems aim to support clinical trials by providing an automated search for eligible patients in the databases of health care institutions like university hospitals. To integrate patient recruitment systems into existing workflows, previous works have assessed user requirements for these tools. In this study, we tested patient recruitment systems KAS+ and recruIT as part of the MIRACUM (Medical Informatics in Research and Care in University Medicine) project.

Objective
Our goal was to investigate whether and to what extent the 2 different evaluated tools can meet the requirements resulting from the first requirements analysis, which was performed in 2018-2019. A user survey was conducted to determine whether the tools are usable in practice and helpful for the trial staff. Furthermore, we investigated whether the test phase revealed further requirements for recruitment tools that were not considered in the first place.

Methods
We performed semistructured interviews with 10 participants in 3 German university hospitals who used the patient recruitment tools KAS+ or recruIT for at least 1 month with currently recruiting trials. Thereafter, the interviews were transcribed and analyzed by Meyring method. The identified statements of the interviewees were categorized into 5 groups of requirements and sorted by their frequency.

Results
The evaluated recruIT and KAS+ tools fulfilled 7 and 11 requirements of the 12 previously identified requirements, respectively. The interviewed participants mentioned the need for different notification schedules, integration into their workflow, different patient characteristics, and pseudonymized screening lists. This resulted in a list of new requirements for the implementation or enhancement of patient recruitment systems.

Conclusions
Trial staff report a huge need of support for the identification of eligible trial participants. Moreover, the workflows in patient recruitment differ across trials. For better suitability of the recruitment systems in the workflow of different kinds of trials, we recommend the implementation of an adjustable notification schedule for screening lists, a detailed workflow analysis, broad patient filtering options, and the display of all information needed to identify the persons on the list. Despite criticisms, all participants confirmed to use the patient recruitment systems again.
Feasibility of Measuring Smartphone Accelerometry Data During a Weekly Instrumented Timed Up-and-Go Test After Emergency Department Discharge: Prospective Observational Cohort Study
Authors: Suffoletto Brian , Kim David , Toth Caitlin , Mayer Waverly , Glaister Sean , Cinkowski Chris , Ashenburg Nick , Lin Michelle , Losak Michael 
Published: July 2024

Abstract

Background
Older adults discharged from the emergency department (ED) face elevated risk of falls and functional decline. Smartphones might enable remote monitoring of mobility after ED discharge, yet their application in this context remains underexplored.

Objective
This study aimed to assess the feasibility of having older adults provide weekly accelerometer data from an instrumented Timed Up-and-Go (TUG) test over an 11-week period after ED discharge.

Methods
This single-center, prospective, observational, cohort study recruited patients aged 60 years and older from an academic ED. Participants downloaded the GaitMate app to their iPhones that recorded accelerometer data during 11 weekly at-home TUG tests. We measured adherence to TUG test completion, quality of transmitted accelerometer data, and participants’ perceptions of the app’s usability and safety.

Results
Of the 617 approached patients, 149 (24.1%) consented to participate, and of these 149 participants, 9 (6%) dropped out. Overall, participants completed 55.6% (912/1639) of TUG tests. Data quality was optimal in 31.1% (508/1639) of TUG tests. At 3-month follow-up, 83.2% (99/119) of respondents found the app easy to use, and 95% (114/120) felt safe performing the tasks at home. Barriers to adherence included the need for assistance, technical issues with the app, and forgetfulness.

Conclusions
The study demonstrates moderate adherence yet high usability and safety for the use of smartphone TUG tests to monitor mobility among older adults after ED discharge. Incomplete TUG test data were common, reflecting challenges in the collection of high-quality longitudinal mobility data in older adults. Identified barriers highlight the need for improvements in user engagement and technology design.
Effectiveness of a Bullying Intervention (Be-Prox) in Norwegian Early Childhood and Education Care Centers: Protocol for a Cluster Randomized Controlled Trial
Authors: Kvestad Ingrid , Adolfsen Frode , Angeles Renira Corinne , Brandseth Oda Lekve , Breivik Kyrre , Evertsen Janne Grete , Foer Irene Kvåle , Haaland Morten , Homola Birgit Millerjord , Hoseth Gro Elisabeth , Jonsson Josefine , Kjerstad Egil , Kyrrestad Henriette , Martinussen Monica , Moberg Annelene , Moberg Karianne , Skogstrand Anita , Solberg Line Remme , Aasheim Merete 
Published: July 2024

Background
A new and growing body of research has studied bullying among children in early childhood education and care centers (ECECs). The Bernese Program (Be-Prox) is designed to systematically prevent and handle bullying between children in Swiss ECECs. However, the effectiveness of the Be-Prox intervention has not yet been explored in a Norwegian ECEC setting.

Objective
This study aims to evaluate the effectiveness of Be-Prox in preventing and handling bullying among peers in Norwegian ECECs.

Methods
ECECs from 2 Norwegian municipalities were invited to participate in a cluster randomized controlled trial (RCT) to evaluate the effectiveness of the Be-Prox intervention on peer bullying in Norwegian ECECs. After baseline measures were taken, project ECECs were randomized to either an intervention or a control arm. The Be-Prox intervention was introduced to ECECs in the intervention arm through 6 modules over a 9-month period immediately after the randomization. ECECs in the control arm participated in the data collection and were offered the Be-Prox intervention the following year. The primary outcome of the effect evaluation is the mean sum of negative behavior between peers after the Be-Prox training is completed in the intervention arm. Secondary outcomes include child bystander behavior, teacher self-efficacy, and ECEC’s authoritative climate. An extensive implementation and process evaluation, as well as cost-effectiveness analyses, will be conducted alongside the RCT.

Results
Baseline data collection was conducted in September 2023, and the postintervention data collection started in May 2024. At baseline, we collected data on 708 children and 413 personnel from 38 project ECECs in the 2 Norwegian municipalities. The results from the study will be available in late 2024 at the earliest.

Conclusions
The proposed project includes a comprehensive evaluation of the effectiveness of Be-Prox in Norwegian ECECs directly targeting the prevention and handling of bullying, including implementation and cost-effectiveness evaluations. The results from the project have the potential to fill in identified knowledge gaps in the understanding of negative behavior and bullying between peers in ECECs, and how these may be prevented. If proven efficient, our ambition is to offer Be-Prox to Norwegian ECECs as an evidence-based practice to prevent and handle bullying among preschool children.

Trial Registration
ClinicalTrials.gov NCT06040437; https://clinicaltrials.gov/study/NCT06040437

International Registered Report Identifier (IRRID)
DERR1-10.2196/60626
Effectiveness Test Of Papaya (Carrica Papaya L.) Flower Extract On Blood Sugar Level Of The Sucrose-Induced Male Mice (Mus Musculus L.)
Authors: Marpaung Febri Sri , Tampubolon Ester Juanita br. , Andika Muhammad Insan , Lubis Yolanda Eliza Putri , Mutia Maya Sari 
Published: July 2024

The papaya (Carica papaya L) flower contain flavonoids, tannins, and triterpenoid steroids which function as antidiabetic. This study was conducted to determine the antidiabetic effect of papaya (Carica papaya L) flower extract on sucrose-induced male mice. In this study, mice were made diabetic by inducing them with sucrose at a dose of 160 mg/kg BW. A total of 25 mice were grouped homogeneously into 5 groups, consisting of a negative control group (CMC 0.5%), a positive control group (no administration), a group with a dose of 200 mg/kg BW, a group with a dose of 400 mg/Kg. BW, and the group with a dose of 500 mg/Kg BW. Measurement of blood sugar levels of mice was carried out before administration of sucrose, after administration of sucrose and after administration of papaya flower extract. The results showed that the three doses had an antidiabetic effect, and the administration of papaya flower extract at a dose of 200 mg/Kg BW showed a better effect than the negative control.
LAJU FILTRASI KERANG HIJAU (Perna viridisLinn. 1758) YANG BERBEDA UKURAN PADA BERBAGAI TINGKAT SALINITAS TERHADAP MIKROALGA Chaetoceros calcitrans (Paulsen. 1968)
Authors: Ningsih Ika rahayu , Efendi Eko , Yuliana Darma 
Published: July 2024

Kerang hijau (Perna viridis) merupakan organisme yang memiliki sifat non selective filter feeder yang merupakan pemakan mikroalga di perairan. Mikroalga dapat tumbuh tidak terkontrol akibat banyaknya kandungan nutrien di perairan, hal ini dapat menyebabkan terjadinya kelimpahan mikroalga. Penelitian ini bertujuan untuk mengkaji laju filtrasi kerang hijau yang berbeda ukuran pada tingkat salinitas yang berbeda terhadap Chaetoceros calcitrans (Paulsen. 1968). Penelitian ini menggunakan metode eksperimental dengan rancangan acak lengkap faktorial denganÂ Sembilan perlakuan dan tiga taraf pengulangan. Masing-masing perlakuan mengkombinasikan salinitas 25â€°, 30â€°, 35â€° dan ukuran 3, 6 and 8 cm. Kepadatan mikroalga yang diberikan pada tiap perlakuan sebanyak 5 x 106 sel/l. Hasil penelitian menunjukan tidak adanya pengaruh ukuran kerang hijau dan salinitas terhadap laju filtrasi kerang hijau yang diberi pakan Chaetoceros calcitrans.