bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarities and differences in the clinical features and management of primary lymphedema and kaposiform hemangioendothelioma associated with lymphedema in children
Authors: Zhang Yujia , Qiu Tong , Yang Congxia , Zhou Jiangyuan , Yang Min , Gong Xue , Zhang Zixin , Lan Yuru , Zhang Xuepeng , Chen Siyuan , Ji Yi 
Published: February 2025

BackgroundPrimary lymphedema (PLE) and kaposiform hemangioendothelioma-related lymphedema (KLE) are rare vascular anomalies (VAs). This study aimed to examine the clinical features, management, and prognosis of PLE and KLE.MethodThe clinical features, imaging, treatments, and outcomes of 12 patients with PLE and 12 patients with KLE were retrospectively reviewed.ResultsThe mean age at which signs/symptoms were diagnosed was 68.2 months for PLE patients and 25 months for KLE patients. In PLE, the involvement of multiple sites is common, whereas in KLE, it typically affects a single site. Morbid obesity, which is common in adult patients, is rare in pediatric PLE and KLE patients. Imaging agent accumulation was observed in KLE but not in PLE via lymphoscintigraphy. In contrast, complications of PLE primarily involve skin and soft tissue, whereas musculoskeletal system complications are more common in KLE. Regarding prognosis, most patients stabilize or even experience lesion regression after standard treatment.ConclusionPLE and KLE share clinical symptoms. PLE often involves multiple sites, whereas KLE typically presents unilaterally with local lymphatic stasis. Standardized treatment enables the majority of children with lymphedema to control the disease without progression, with KLE showing potential reversibility. Given their rarity, a multidisciplinary approach is crucial for diagnosis and management.
Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma
Authors: Xu Haoyu , Peng Senlin , Li Junwu , Bai Yuanyuan , Zhao Guozhi , Liang Simin , Tang Wei 
Published: February 2025

BackgroundClear cell renal cell carcinoma (ccRCC) has the highest morbidity among renal cell carcinoma (RCC) subtypes. While existing clinical pharmacological intervention strategies have achieved certain efficacy, challenges including inevitable drug resistance and intricate immune heterogeneity of ccRCC continue to hinder their biomedical application. Therefore, developing novel immunotherapeutic agents and identifying patients who can gain the greatest benefits from these therapies are urgent issues.MethodsTo address these challenges, mRNA expression profile and clinical data of ccRCC were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. These data were integrated and randomly allocated into training and test sets. Immune-related differentially expressed genes (IRDEGs) were used to construct an immune-related gene prognostic index (IRGPI). Both prognostic performance metrics and immune phenotyping were employed to evaluate the effectiveness of the model. Furthermore, model IRDEGs (mIRDEGs) in two risk subgroups were leveraged to select potential therapeutic compounds. Afterwards, network pharmacology and molecular docking techniques were used to elucidate the anti-cancer mechanisms of Zebularine (Zeb). Finally, the anti-cancer efficacy of Zeb was validated through in vivo and in vitro experiments.ResultsOur constructed IRGPI exhibited superior prognostic performance. The drug screening revealed Zeb potentially targets the PI3K-Akt signaling pathway to exert its anti-cancer effects. Subsequent experimental validation corroborated these theoretical findings.ConclusionThis study presents a prognostic model to evaluate immune cell infiltration and predict the prognosis of ccRCC patients. The identified small molecule compound provides a novel therapeutic avenue for treating ccRCC patients.
Mapping the perceived impacts of a social innovation program on women’s agency and life satisfaction
Authors: Tbaishat Dina , Qtaishat Lina , Eggerman Jannik Joseph , Panter-Brick Catherine , Dajani Rana 
Published: February 2025

IntroductionCross-cultural research measuring how women perceive their sense of agency and catalyze social innovation has been limited. We conducted a mixed-methods study to learn about women’s agency and life satisfaction, while evaluating the perceived benefits of a social innovation program (We Love Reading), in the UAE which, in 2022, launched a nationwide reading promotion strategy.Methods and resultsWe implemented the Sense of Agency (SoA) scale and Cantril Ladder of Life Scale with a sample of 78 female Emirati students, then conducted two Fuzzy Cognitive Mapping (FCM) sessions with 13 respondents. The FCM sessions helped to develop local definitions of agency and life satisfaction, map causal relationships, and run scenarios to identify program benefits. This highlighted 6 core dimensions of personal and relational agency—ability, control, strength, authority, freedom of action, and responsibility. We Love Reading boosted several aspects of agency and life satisfaction.DiscussionOur findings suggest that We Love Reading can help change mindsets and meet a fundamental policy goal related to reading habits and knowledge empowerment in the Arab World. They show the need for mapping causal reasoning in systematic ways, taking into account different dimensions of agency in environments where social innovation can flourish.
Development and evaluation of a 3D ensemble framework for automatic diagnosis of early osteonecrosis of the femoral head based on MRI: a multicenter diagnostic study
Authors: Yang Miao , Hsiang Fuchou , Li Chengfan , Chen XiaoYi , Zhang Changqing , Sun Guangchen , Lou Qiliang , Zhu Wenhui , Zhao Hongtao , Liu Feng , Ding Xuehai , Xu Jun 
Published: February 2025

BackgroundEfficient and reliable diagnosis of early osteonecrosis of the femoral head (ONFH) based on MRI is crucial for the formulation of clinical treatment plans. This study aimed to apply artificial intelligence (AI) to achieve automatic diagnosis and visualization of early ONFH, thereby improving the success rate of hip-preserving treatments.MethodThis retrospective study constructed a multicenter dataset using MRI data of 381 femoral heads from 209 patients with ONFH collected from four institutions (including 239 early ONFH cases and 142 non-ONFH cases). The dataset was divided into training, validation, and internal and external test datasets. This study developed a 3D ensemble framework to automatically diagnose early osteonecrosis of the femoral head based on MRI and utilized 3D Grad-CAM to visualize its decision-making process. Finally, the diagnostic performance of the framework was experimentally evaluated on the MRI dataset and compared with the diagnostic results of three orthopedic surgeons.ResultsOn the internal test dataset, the 3D-ONFHNet framework achieved overall diagnostic performance with an accuracy of 93.83%, sensitivity of 89.44%, specificity of 95.56%, F1-score of 87.67%, and AUC of 95.41%. On the two external test datasets, the framework achieved overall diagnostic accuracies of 87.76% and 87.60%, respectively. Compared to three orthopedic surgeons, the diagnostic performance of the 3D-ONFHNet framework was comparable to that of senior orthopedic surgeons and superior to that of junior orthopedic surgeons.ConclusionsThe framework proposed in this study can generate staging results for early ONFH and provide visualizations of internal signal changes within the femoral head. It assists orthopedic surgeons in screening for early ONFH on MRI in a clinical setting, facilitating preoperative planning and subsequent treatment strategies. This framework not only enhances diagnostic efficiency but also offers valuable diagnostic references for physicians.
Feasibility of resonant vibration of piezoelectric material for noncontact evaluation of electrical resistance
Authors: Yoshida Aya , Adachi Kanta , Nakamura Nobutomo 
Published: February 2025

Abstract
When a conductive material is placed near a piezoelectric material vibrating at a resonant frequency, the electric field excited around the piezoelectric material is suppressed, and the apparent piezoelectric coefficient decreases, resulting in a decrease in the resonant frequency. In this study, we investigated availability of this phenomenon for noncontact electrical resistance measurement. The resonant frequencies of lithium niobate and quartz oscillator were measured for the eight different resonant modes, and changes in the resonant frequencies when the conductor and semiconductor were placed near the piezoelectric materials were evaluated. In all cases, the resonant frequency decreased, and the change ratio depended on the resistivity of the conductor and semiconductor. In addition, as the resonant frequency of the measured mode increased, the change ratio became smaller. From these results, we proposed a resistance measurement methodology and confirmed that it can be used for estimating the electrical resistivity qualitatively.
Surface activated Cu/SiO2 hybrid bonding for room temperature 3D integration
Authors: Abadie Karine , Renaud Pablo , Fournel Frank , Michaud Laurent Gaëtan , Danner Matthias , Dornetshumer Michael , Lecouvey Christophe , Papon Anne-Marie , Chevalier Isabelle , Monniez Theo , Matei Constantin , David Thomas , Dominguez Sebastien , Dubarry Christophe 
Published: February 2025

Abstract
We evaluated Surface activated bonding (SAB), a room temperature bonding, for hybrid surfaces bonding. At first, SAB process was evaluated on copper and silicon oxide full sheet surfaces, in order to separately study the impact of the SAB activation on both types of materials embedded in a hybrid surface layer. Then, 200 mm wafers with 2.5 µm copper pads 2.5 µm apart in a silicon oxide matrix were used to probe the impact of activation with atomic force microscopy. Two test vehicles were then manufactured in order to morphologically and electrically study the bonding interface. Thus, hybrid wafers were aligned and bonded in an EVG®COMBOND® equipment. Cross-sectional scanning and transmission electron microscopy characterizations were performed on both test vehicles in order to observe the bonding interface. Electrical tests were also performed at the end of full 3D integration on daisy chain structures to demonstrate a high connectivity through the bonding interface.
SENTIDOS À VIVÊNCIA DE MULHER JOVEM COM IRC EM DIÁLISE: ANÁLISE DE DISCURSO FRANCESA
Authors: Miranda de Carvalho Hosana de Nazaré , Formigosa Dociana Erica Cabral , Cavalcante Inara Mariela da Silva , Teixeira Elizabeth , Ferreira Maria Goreth Silva 
Published: February 2025

Experiências de adoecimento podem ser marcantes, especialmente a Insuficiência Renal Crônica (IRC) em grupos específicos como mulheres jovens, podendo gerar inquietações, rupturas e necessidade de adaptação. Pouco se conhece sobre como a mulher jovem (MJ) sente, vive e expressa suas vivências com a IRC. O objetivo é identificar os impactos da IRC e da diálise na vida da MJ; identificar as formações discursivas mobilizadas em seu discurso; e analisar os significados e sentimentos atribuídos ao tratamento. O estudo exploratório, qualitativo, baseado no Método Criativo Sensível, com as dinâmicas "Linha da Vida" e "Corpo Saber”, em um serviço de diálise de um hospital público na Amazônia brasileira. Participaram 15 MJs entre 21 e 40 anos. Os dados foram analisados pela Análise de Discurso Francesa, com o aporte teórico de Paulo Freire e da Teoria de Enfermagem de Callista Roy. Nos resultados elementos discursivos como metáforas, silenciamento, paráfrases, polissemia, polifonia e ethos revelaram a dialética de um cotidiano impactado pela IRC. Os impactos da IRC vão além da adesão à dieta, terapia e medicamentos, abrangendo o desejo de engravidar, transplantar, criar e educar filhos, empreender e questões de identidade e gênero. A vida da MJ é gerenciada pelas demandas da terapia, com a IRC e a diálise influenciando seus processos vitais, distintos dos de outros grupos. Planos terapêuticos dialógicos podem facilitar a vivência da MJ com a diálise.
PEMBERDAYAAN IBU-IBU PKK MELALUI PELATIHAN PEMBUATAN ECOPRINT DARI DAUN DAN BUNGA SEKITAR SEBAGAI PENGEMBANGAN UMKM DI DESA PAGERGUNUNG
Authors: Kusumawati Rizqi Adhyka , Afuan Fajrian Putra  , Selfira Salsabila  
Published: February 2025

Desa Pagergunung merupakan salah satu desa dari 16 desa dikecamatan Ngablak kabupaten Magelang Provinsi Jawa Tengah yang terletak di Kawasan kaki gunung Telomoyo dan Gunung andong. Desa Pagergunung merupakan daerah berbukit atau gunung dan bergelombang.Sehingga membuat desa Pagergunung memiliki iklim yang sejuk dan tanah yang subur sehinggakaya akan hasil bumi terutama di bidang pertanian. Desa Pagergunung kini menjadi salah satu desa wisata yang sedang berkembang, dengan adanya pengembangan Embung Sekembang kini membuat desa Pagergunung semakin dikenal oleh masyarakat banyak baik di dalam kota Magelang maupun dari luar kota Magelang. Gencaran pembangunan wisata desa Pagergunung akan berjalan seimbang jika diiringi dengan peningkatan keterampilan dan kreativitas warga sekitar untuk mempersiapakan dan menyuguhkan hasil dari khas warga desa setempat, sehingga harapan kedepannya bisa meningkatkan kesejahteraan warga Desa Pagergunung. Letak geografi yang sangat strategis dikelilingi oleh pegunungan, iklim yang sejuk serta tanah yang subur membuat Desa Pagergunung memiliki banyak jenis tanaman yang bagus, dan unik tumbuh liar dan subur. Potensi tersebut dapat dimanfatkan oleh masyarakat sekitar menjadikan ide ecoprint ini dapat diaplikasikan serta dikembangkan untuk memulai sebuah usaha baru. Di samping itu, Pagergunung masih belum memiliki oleh-oleh/buah tangan yang dapat dijadikan ciri khas daerahnya, dan dapat mengundang daya tarik pengunjung untuk singgah atau berkunjung di Pagergunung. Peluang-peluang yang telah ada ini belum dimanfaatkan secaramaksimal, dengan melihat masih minimnya pengetahuan dan keterampilan warga memanfaatkan potensi yang ada belum bisa dijalan secara maksimal. Berdasarkan permasalahan tersebut di atas maka di perlukan upaya pemberdayaan masyarakat di Desa Pagergunung dengan tujuan yaitu terciptanya peningkatan keterampilan dalam berwirausaha membuat produk ecoprint, sehingga luaran yang dihasilkan dari kegiatan pengabdian ini adalah: 1) Terciptanya peningkatan SDM masyarakat di Desa Pagergunung khususnya untuk ibu-ibu PKK membuat ecoprint, dan 2) terciptanya produk ecoprint oleh-oleh khas desa Pagergunung. Metode yang digunakan adalah pelatihan, pendampingan, dan implementasi.

Kata kunci : Ecoprint, ibu-ibu Kelompok Wanita Tani, PKK, Desa Pagergunung
Analisis Sistem Kendali Dan Monitoring Motor Induksi Tiga Fasa Berbasis Scada
Authors: Ulil Amri Ulil Amri , Pratiwi Amelya Indah , Humena Steven 
Published: February 2025

Motor induksi tiga fasa merupakan salah satu alat yang digunakan untuk mengubah energi listrik menjadi energi gerak yang biasa digunakan sebagai aktuator atau alat penggerak di industri. Melihat konsumsi daya yang digunakan pada motor induksi tiga fasa dengan metode konvensional serta dilihat dari hasil investigasi dan analisa penyerapan daya di industri masih terbilang tinggi, maka dengan menggunakan variable frequency drive bisa mereduksi penyerapan daya pada motor induksi tiga fasa. Pada penelitian ini dirancang skema kendali motor secara konvensional dan kendali motor menggunakan variable frequency drive dengan monitoring scada. Pada rancangan ini diamati tegangan, arus, dan frekuensi untuk mengetahui penyerapan daya pada motor induksi tiga fasa dengan menggunakan dua metode kendali motor. Hasil pengamatan menunjukan bahwa kendali motor dengan menggunakan metode konvensional lebih banyak menyerap daya jika dibandingkan dengan kendali motor dengan menggunakan variable frequency drive. Dan juga ketahanan motor yang lebih lama masa penggunaannya yaitu dengan menggunakan variable frequency drive jika dibandingkan dengan menggunakan metode konvensional. Monitoring karakteristik motor induksi tiga fasa lebih ramah pengguna jika mnggunakan variable frequency drive dibanding menggunkan metode konvensional. Kendali motor dengan menggunakan variable frequency drive lebih bervariasi sesuai dengan kebutuhan konsumen.
ПРО ВИКОНАННЯ У 2024 р. НАУКОВИХ ДОСЛІДЖЕНЬ ДЛЯ ПІДТРИМКИ МОЛОДИХ ВЧЕНИХ
Authors: Коваленко Валентина Володимирівна , Бужинецька Ксенія Борисівна , Предко Вікторія Володимирівна 
Published: February 2025

У публікації представлені результати виконаних у 2024 р. прикладних наукових досліджень для підтримки молодих вчених, які працюють у наукових установах НАПН України. Дослідження здійснювалися за результатами конкурсного відбору в січні 2024 р., який було проведено з метою підтримки та активізації наукової діяльності молодих вчених НАПН України, сприяння розвитку їх професійних якостей і творчого потенціалу.Здобуті молодими вченими академії результати досліджень спрямовані на науково-методичне забезпечення природничо-математичної освіти учнів, удосконалення методичної підготовленості вчителів щодо використання дидактичних можливостей штучного інтелекту у навчанні; модифікацію технологій для надання психологічної допомоги родинам із дітьми з особливими потребами у період війни; формування стійкого балансу локусу контролю як провідного фактору зміцнення ментального здоров’я української молоді в умовах війни.Наукові результати проведених досліджень упроваджено у закладах освіти різних рівнів, психологічних службах, а також в органах державної влади та органах місцевого самоврядування.
The Impact of Extended CO2 Cross Sections on Temperate Anoxic Planet Atmospheres
Authors: Broussard Wynter , Schwieterman Edward W. , Sousa-Silva Clara , Sanger-Johnson Grace , Ranjan Sukrit , Venot Olivia 
Published: February 2025

Abstract
Our interpretation of terrestrial exoplanet atmospheric spectra will always be limited by the accuracy of the data we use as input in our forward and retrieval models. Ultraviolet molecular absorption cross sections are one category of these essential model inputs; however, they are often poorly characterized at the longest wavelengths relevant to photodissociation. Photolysis reactions dominate the chemical kinetics of temperate terrestrial planet atmospheres. One molecule of particular importance is CO2, which is likely present in all terrestrial planet atmospheres. The photolysis of CO2 can introduce CO and O, as well as shield tropospheric water vapor from undergoing photolysis. This is important because H2O photolysis produces OH, which serves as a major reactive sink to many atmospheric trace gases. Here, we construct CO2 cross-section prescriptions at 195 K and 300 K extrapolated beyond 200 nm from measured cross sections. We compare results from the implementation of these new cross sections to the most commonly used CO2 prescriptions for temperate terrestrial planets with Archean-like atmospheres. We generally find that the observational consequences of CO2 dissociation beyond 200 nm are minimal so long as our least conservative (highest opacity) prescription can be ruled out. Moreover, implementing our recommended extended CO2 cross sections does not substantially alter previous results that show the consequential photochemical impact of extended H2O cross sections.
Optical Polarimetry of WR 1 Consistent with a CIR and 17 days Rotation
Authors: Steenken Nicolaus , Ignace Richard , St-Louis Nicole , Lenoir-Craig Guillaume 
Published: February 2025

Abstract
New visible-band linear polarimetry of the star WR 1 (HD 4004) is presented. This early N-rich Wolf–Rayet star has previously been reported as harboring a Corotating Interaction Region structure threading its wind, implying a stellar rotation period of 16.9 days. Polarization measurements in the Q − U diagram obtained over a span of more than 5 weeks with sampling every few days are revealing (a) variability consistent with the previously reported period and (b) a loop morphology consistent with theoretical models.
Closed nuclear fuel cycle of thermal and fast reactors with fuel self-sufficiency
Authors: Shmelev Anatoly N. , Apse Vladimir A. , Kulikov Evgeny G. , Kulikov Gennady G. , Glebov Vasily B. 
Published: February 2025

The paper presents the results obtained in numerical evaluations of a possibility to reach self-sufficiency of fissile materials in the joint system of fast and thermal reactors. These studies considered the joint system consisting of thermal light-water reactors of VVER-type and fast lead-cooled reactors of BREST-type, which are operated within the frames of the closed (Th-U-Pu) fuel cycle. It was assumed that fast reactors (FR) of BREST-type used the mixed thorium-plutonium nitride fuel, while thermal reactors (TR) of VVER-type used the mixed oxide fuel of natural uranium and 233U. Uranium isotope 233U was produced in the Th-fraction of FR fuel for further introduction into the fresh composition of TR fuel, while plutonium was produced in the natural uranium fraction of TR fuel for further introduction into the fresh composition of FR fuel. The numerical studies resulted in the determination of the conditions necessary to provide fuel self-sufficiency in the joint TR-FR system. The following key findings of the research may be noted:
– It is demonstrated the possibility to create the joint TR-FR system with inherent fuel self-sufficiency;
– Involvement of thorium and 233U in the closed NFC of the joint TR-FR system can arrange an optimal regime for production and consumption of main FM;
– Purposeful change of thermal power and introduction of natural uranium in the fuel composition of BREST-type FR made it possible to reach fuel self-sufficiency of the joint TR-FR system;
– Application of radiogenic lead instead of natural lead allowed us to reduce necessary values of thermal power and content of natural uranium nitride in the fuel of BREST-type FR.
From ICU to “I SEE YOU”: Introducing the family member in COVID-ICU
Authors: Bartoli Davide , Trotta Francesca , Pucciarelli Gianluca , Petrosino Francesco 
Published: February 2025

The death rates in Intensive Care Units (ICU) caused by COVID-19 were 37.3%,1 creating traumatic outcomes in family members forced to detach from their relative, in their homes.2
Patient and Family Engagement in ICU has been defined as: “an active partnership between health professionals and patients and families working at every level of the healthcare system to improve health and the quality, safety, and delivery of healthcare.”3 Involving family members in a pandemic era in COVID-ICUs was a complex challenge, as a balance had to be struck between the five ethical principles of Family Centred Care's (FCC)4 and the safety of visitors and patients5 and thed increased burden of care of health professionals who worked in the COVID-ICUs6 which were to contain the fear of family members7 and support the family member to perform advanced activities such as donning/doffing of Personal Protective Equipment (PPE).8 [...]