bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Dimethylbut‐2‐ynedioate‐Mediated Esterification of Acids via sp3 C—N Bond Cleavage of Benzylic Tertiary Amines.
Authors: Shen Hao , Lu Xing , Jiang Ke‐Zhi , Yang Ke‐Fang , Lu Yixin , Zheng Zhan‐Jiang , Lai Guo‐Qiao , Xu Li‐Wen 
Published: March 2013

AbstractThe synthetic use of tertiary amines for the esterification of equimolar amounts of carboxylic acids involves an sp3 C—N bond cleavage.
ChemInform Abstract: Self‐Assembled Monolayer‐Coated Gold Nanoparticle Catalyzed Aerobic Oxidation of α‐Hydroxy Ketones in Water: An Efficient One‐Pot Synthesis of Quinoxaline Derivatives.
Authors: Bhattacharya Tamalika , Sarma Tridib K. , Samanta Sampak 
Published: March 2013

AbstractThe complex Pd system promotes the aerobic oxidation of aryl‐substituted α‐hydroxy ketones to aryl 1,2‐diketones.
ChemInform Abstract: Efficient Synthesis of Trifluoromethylated Dihydrochalcones, Aryl Vinyl Ketones and Indanones by Superelectrophilic Activation of 4,4,4‐Trifluoro/3‐(trifluoromethyl)crotonic Acids.
Authors: Prakash G. K. Surya , Paknia Farzaneh , Narayanan Arjun , Rasul Golam , Mathew Thomas , Olah George A. 
Published: March 2013

AbstractA novel and efficient direct synthetic route to trifluoromethylated dihydrochalcones (III), aryl vinyl ketones (V), and indanones like (VIII) is based on Friedel—Crafts reactions under superacidic conditions.
ChemInform Abstract: Ruthenium‐ and Sulfonamide‐Catalyzed Cyclization Between N‐Sulfonyl Imines and Alkynes.
Authors: Zhao Peng , Wang Fen , Han Keil , Li Xingwei 
Published: March 2013

AbstractTreatment of aromatic sulfonyl imines with alkynes under conditions A) results in effective formation of various indenamines.
ChemInform Abstract: Organocatalytic Activation of Polycyclic Aromatic Compounds for Asymmetric Diels—Alder Reactions.
Authors: Jiang Hao , Rodriguez‐Escrich Carles , Johansen Tore Kiilerich , Davis Rebecca L. , Joergensen Karl Anker 
Published: March 2013

AbstractActivation of the π‐system of anthracene in the presence of a chiral aminocatalyst significantly accelerates the cycloaddition process.
ChemInform Abstract: Tris(oxazoline)/Copper‐Catalyzed Coupling of Alkynes with Nitrones: A Highly Enantioselective Access to β‐Lactams.
Authors: Chen Jiang‐Hua , Liao Sai‐Hu , Sun Xiu‐Li , Shen Qi , Tang Yong 
Published: March 2013

AbstractAn efficient ligand is successfully applied to the enantio‐ and diastereoselective synthesis of the title compounds.
ChemInform Abstract: Domino Reactions of Donor—Acceptor‐Substituted Cyclopropanes for the Synthesis of 3,3′‐Linked Oligopyrroles and Pyrrolo[3,2‐e]indoles.
Authors: Kaschel Johannes , Schneider Tobias F. , Kratzert Daniel , Stalke Dietmar , Werz Daniel B. 
Published: March 2013

AbstractA novel strategy to build the desired oligopyrroles and some congeners uses the reaction of bis‐cyclopropylannulated tetrahydrofurans with primary amines.
ChemInform Abstract: Tandem 1,5‐Migration/Michael Reactions to Prepare Adducts of Pyrazolone Derivatives: Protecting Group Directed Rearrangement.
Authors: Lu Zhijin , Xie Chen , Han Jianlin , Pan Yi 
Published: March 2013

AbstractReaction of pyrazolines of type (I) with nitroolefins (II) follows the title sequence and affords 4‐substituted‐5‐pyrazolone derivatives.
ChemInform Abstract: Transition Metal‐Free Direct C—H Bond Thiolation of 1,3,4‐Oxadiazoles and Related Heteroarenes.
Authors: Zou Liang‐Hua , Reball Jens , Mottweiler Jakob , Bolm Carsten 
Published: March 2013

AbstractA simple procedure is elaborated for the thiolation of different heterocyclic substrates, e.g. oxadiazoles (I), indoles (IV), benzothiazole (VII).
ChemInform Abstract: Regioselective Addition of 1,3‐Dicarbonyl Dianions to Carbonyl Compounds: One‐Pot Lactonization and Ketalization of δ‐Hydroxy‐β‐keto Esters to Protected Pyrone Derivatives.
Authors: Ghorai Manas K. , Halder Sandipan , Samanta Sauvik 
Published: March 2013

AbstractThe present new method is also applied to chiral aldehyde (VII) and the appropriate addition product is obtained after protection of the OH‐group as silyl ether as a mixture of diastereomers.
ChemInform Abstract: Structure—Activity Relationships of Biflavonoids for β‐Secretase (BACE‐1) Inhibitory Activity.
Authors: Sasaki Hiroaki , Kitoh Yuki , Miki Kazuhiko , Kinoshita Kaoru , Koyama Kiyotaka , Kaneda Miyuki , Takahashi Kunio 
Published: March 2013

AbstractIt is shown that the structure of a flavanone‐flavone dimer with a methoxy group at the C‐4 position as in compounds (S)‐(Ia) and (S)‐(Ib) is important for a strong BACE‐1 inhibitory activity.
ChemInform Abstract: Synthesis and Evaluation of a Series of Piperidine‐2,6‐dione‐piperazine (piperidine) Derivatives as Multireceptor Atypical Antipsychotics.
Authors: Chen Yin , Xu Xiangqing , Liu Xin , Liu Bi‐Feng , Zhang Guisen 
Published: March 2013

AbstractCompound (I) shows high affinity for dopamine D2 and D3, serotonin 5‐HT1A, 5‐HT2A, and 5‐HT2C receptors with a low affinity for the H1 receptor.
ChemInform Abstract: An Efficient and Regioselective Synthetic Approach Towards Fluorinated Quinolinylphosphonates.
Authors: Duda Blazej , Tverdomed Sergey N. , Roeschenthaler Gerd‐Volker 
Published: March 2013

AbstractElectron‐deficient fluorinated acetylenephosphonates (II) react with 2‐aminobenzaldehyde imines (I) to give biologically interesting CF2‐containing quinolinylphosphonates (III).
ChemInform Abstract: Copper Acetate Monohydrate: A Cheap but Efficient Oxidant for Synthesizing Multi‐Substituted Indolizines from Pyridinium Ylides and Electron Deficient Alkenes.
Authors: Hu Huayou , Feng Junjun , Zhu Yulan , Gu Ning , Kan Yuhe 
Published: March 2013

AbstractThe biologically important heterocyclic system is readily available in moderate to good yields and various functionalities are tolerated.
ChemInform Abstract: One‐Pot Chemoselective Bis(Suzuki—Miyaura Cross‐Coupling): Efficient Access to 3,9‐Bis[(hetero)aryl]‐4H‐pyrido[1,2‐a]pyrimidin‐4‐one Derivatives under Microwave Irradiation.
Authors: Kabri Youssef , Crozet Maxime D. , Primas Nicolas , Vanelle Patrice 
Published: March 2013

AbstractThe different reactivities of the ring positions in compound (I) allow for chemoselective one‐pot double Suzuki‐Miyaura cross‐coupling reactions.
ChemInform Abstract: One‐Pot Syntheses of Novel Pyrazole‐Containing Bisphosphonate Esters at Room Temperature.
Authors: Xiang Haoyue , Qi Xueyu , Xie Yuyuan , Xu Guangyu , Yang Chunhao 
Published: March 2013

AbstractAn efficient general synthetic approach is developed to synthesize pyrazole‐containing bisphosphonate esters from chromenone derivatives via a sequential two‐step one‐pot procedure.
ChemInform Abstract: Copper‐Catalyzed Synthesis of Alkylphosphonates from H‐Phosphonates and N‐Tosylhydrazones.
Authors: Miao Wenjun , Gao Yuzhen , Li Xueqin , Gao Yuxing , Tang Guo , Zhao Yufen 
Published: March 2013

AbstractThis method is a novel access to alkylphosphonates (III) and (V) and can also be used to synthesize alkyldiphenylphosphine oxides, e.g. (VII).
ChemInform Abstract: Calcium Carbonate Polyamorphism and Its Role in Biomineralization: How Many Amorphous Calcium Carbonates Are There?
Authors: Cartwright Julyan H. E. , Checa Antonio G. , Gale Julian D. , Gebauer Denis , Sainz‐Diaz C Ignacio 
Published: March 2013

AbstractReview: 103 refs.
ChemInform Abstract: Recent Applications of Molecular Spectroscopy in Bioorganometallic Chemistry. Part 2. Ferrocenes and Other Organometallic Complexes
Authors: Butler Ian S. , Kengne‐Momo Rosine P. , Vessieres Anne , Jaouen Gerard , Policar Clotilde 
Published: March 2013

AbstractReview: 35 refs.
ChemInform Abstract: Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
Authors: Klan Petr , Solomek Tomas , Bochet Christian G. , Blanc Aurelien , Givens Richard , Rubina Marina , Popik Vladimir , Kostikov Alexey , Wirz Jakob 
Published: March 2013

AbstractReview: 799 refs.
Combined flow cytometric assessment of CD45, HLA‐DR, CD34, and CD117 expression is a useful approach for reliable quantification of blast cells in myelodysplastic syndromes
Authors: Sandes Alex F. , Kerbauy Daniella M. B. , Matarraz Sergio , Chauffaille Maria de Lourdes L. F. , López Antonio , Orfao Alberto , Yamamoto Mihoko 
Published: March 2013

AbstractBackground.Quantification of bone marrow (BM) blasts by cytomorphology is essential for the diagnosis of myelodysplastic syndromes (MDS). Owing to its subjectivity and the potential impact of dysplastic features on accurate identification of blast cells, more objective approaches are required, multiparameter flow cytometry (MFC) being a particularly promising approach in this regard. However, no consensus exists about the optimal combination of markers and strategy to be used.Methods.BM blast counts from 74 MDS patients were evaluated by morphology versus four different MFC phenotypic criteria: “CD34+”, “CD34+ and/or CD117+”, “CD34+, and/or CD117+HLA‐DR+”, and “CD34+ and CD117+HLA‐DR+ plus CD64+CD14−/lo” cells. For each criterium, the percentage of blasts was calculated using either all BM nucleated cells or non‐erythroid CD45+ cells as denominator.Results.The number of “CD34+ and/or CD117+HLA‐DR+”cells showed the highest correlation and agreement with morphological counts, only a minor proportion of cases being misclassified by MFC vs. morphology for the >5% and >10% classification thresholds. In turn, a CD34+ phenotype was insufficient to correctly identify and quantify blasts. Conversely, usage of non‐erythroid BM cells as denominator, or inclusion of “CD34+ and/or CD117+HLA‐DR+ plus CD64+CD14−lo” cells were both associated with overestimated blast counts.Conclusions.Quantification of “CD34+ and/or CD117+HLA‐DR+” cells (from all nucleated BM cells) by MFC is an efficient method for the enumeration of blasts in MDS. However, caution should be taken with replacing morphology by MFC blast counts; its combined use may rather provide complementary information increasing the accuracy and reproducibility of BM blast cell counts in these patients. © 2013 International Clinical Cytometry Society
Copper(I) Oxide Nanocrystals – One Step Synthesis, Characterization, Formation Mechanism, and Photocatalytic Properties
Authors: Singhal Anshu , Pai Mrinal R. , Rao Rekha , Pillai Kodanthakurup T. , Lieberwirth Ingo , Tyagi Avesh K. 
Published: March 2013

AbstractWe report here two different simple, one‐pot, and low cost chemical synthetic routes for the preparation of Cu2O nanocrystals: (a) thermal decomposition of copper–organic precursors copper(II) acetate or copper(II) acetylacetonate in long chain organic solvents oleyl alcohol and trioctylamine, respectively, at 170 °C and (b) a surfactant‐free solvothermal approach involving the reaction of copper(II) acetylacetonate in acetone at 140 °C. The structure and morphology of the nanocrystals have been characterized in detail by XRD, FTIR spectroscopy, Raman spectroscopy, and high‐resolution transmission electron microscopy (HRTEM). The optical properties of the nanocrystals have been explored by diffuse‐reflectance spectroscopy (DRS) and a blueshift of the optical band gap of the nanocrystals is observed owing to size effects. Based on the FTIR, GC–MS, and 13C{1H} NMR studies of post‐reaction solutions, different formation mechanisms for the Cu2O nanocrystals, which depend on the synthetic approach, have been proposed. Oleyl alcohol and trioctylamine play dual roles as solvents and mild reductants and reduce CuII species to CuI species during the course of the thermal decomposition reactions. The solvothermal reaction of copper(II) acetylacetonate in acetone possibly proceeds by acetylacetone‐mediated reduction of Cu2+ to Cu+ in the absence of any reducing agent. The potential of Cu2O nanocrystals as photocatalytic materials for hydrogen generation from water/methanol (2:1) mixtures under UV/Vis irradiation has also been evaluated. The results show that all the nanocystalline Cu2O samples generate H2.
Synthesis of CuO and Cu3N Nanoparticles in and on Hollow Silica Spheres
Authors: Deshmukh Rupali , Schubert Ulrich 
Published: March 2013

AbstractCopper oxide nanoparticles within hollow mesoporous silica spheres were prepared by binding/adsorbing Cu2+ or [Cu(NH3)4(H2O)2]2+ ions on the surface of carbon spheres, followed by formation of a mesoporous silica shell by sol–gel processing and calcination in air. The CuO nanoparticles can subsequently be converted into Cu3N nanoparticles by nitridation with ammonia. The effect of the different copper precursors, i.e. Cu2+ and [Cu(NH3)4(H2O)2]2+, on the nanocomposites was studied. CuO nanoparticles on the outer surface of hollow silica spheres were obtained by thermal treatment of hollow CuSiO3 spheres in air. Nitridation of the CuSiO3 spheres with ammonia resulted in Cu3N@SiO2 composites, with aggregated Cu3N nanoparticles on hollow silica spheres.
Desymmetrization and Switching of Stereoselectivity in Direct Organocatalytic Michael Addition of Ketones to 1,1‐Bis(phenylsulfonyl)ethylene
Authors: Chen Yan ming , Lee Pei‐Hsun , Lin Jun , Chen Kwunmin 
Published: March 2013

AbstractThe organocatalytic desymmetrization was demonstrated for 4‐substituted cyclohexanones by treatment with a vinyl sulfone in the presence of an organocatalyst. The desired Michael adducts were typically obtained in high chemical yields and high to excellent stereoselectivities (up to 97 % yield, 93 % ee). An efficient desymmetrization method was developed for the synthesis of enantiomeric products by using either camphor‐derived pyrrolidine V or cinchonidine‐derived primary amine VII as a catalyst. The absolute stereochemistry of the (2R,4R)‐2‐[2,2‐bis(phenylsulfonyl)ethyl]‐4‐methylcyclohexanone (3a) and (2R,4R)‐2‐[2,2‐bis(phenylsulfonyl)ethyl]‐4‐tert‐butylcyclohexanone (3b) was confirmed by single‐crystal X‐ray structure analyses.
Reaction of Nitrile Oxides with Masked o‐Benzoquinones; Synthesis of Highly Functionalized Isoxazolines
Authors: Chittimalla Santhosh Kumar , Kuppusamy Rajesh , Thiyagarajan Kamalraj , Bandi Chennakesavulu 
Published: March 2013

AbstractMasked o‐benzoquinones, on reaction with nitrile oxides generated in situ from the corresponding hydroxamoyl chlorides, provide [3+2] cycloaddition products or novel isoxazoline derivatives through an unprecedented rearrangement. The isolated [3+2] cycloadducts could be transformed into the corresponding isoxazoline derivatives in the presence of Et3N and highly functionalized benzisoxazoles in the presence of 4 N HCl.
Synthesis and Reactivity of Aryl(alkynyl)iodonium Salts
Authors: Dixon Luke I. , Carroll Michael A. , Gregson Thomas J. , Ellames George J. , Harrington Ross W. , Clegg William 
Published: March 2013

AbstractThe first practical, yet simple, preparation of aryl(alkynyl)iodonium trifluoroacetate salts is described. The generic nature of this synthetic method has allowed the production of a range of aryl(alkynyl)iodonium trifluoroacetate salts with independent variation of both the alkynyl and aryliodo groups in yields of 30–85 %. Application of these new reagents to the synthesis of a series of 2‐arylfuro[3,2‐c]pyridines (40–64 %) highlights the potential of this class of materials as precursors to bioactive heterocyclic structures. These experiments have also demonstrated that, in this case, the effect of the aryliodo group on the reaction is negligible.
Sample Size Considerations of Prediction‐Validation Methods in High‐Dimensional Data for Survival Outcomes
Authors: Pang Herbert , Jung Sin‐Ho 
Published: March 2013

ABSTRACTA variety of prediction methods are used to relate high‐dimensional genome data with a clinical outcome using a prediction model. Once a prediction model is developed from a data set, it should be validated using a resampling method or an independent data set. Although the existing prediction methods have been intensively evaluated by many investigators, there has not been a comprehensive study investigating the performance of the validation methods, especially with a survival clinical outcome. Understanding the properties of the various validation methods can allow researchers to perform more powerful validations while controlling for type I error. In addition, sample size calculation strategy based on these validation methods is lacking. We conduct extensive simulations to examine the statistical properties of these validation strategies. In both simulations and a real data example, we have found that 10‐fold cross‐validation with permutation gave the best power while controlling type I error close to the nominal level. Based on this, we have also developed a sample size calculation method that will be used to design a validation study with a user‐chosen combination of prediction. Microarray and genome‐wide association studies data are used as illustrations. The power calculation method in this presentation can be used for the design of any biomedical studies involving high‐dimensional data and survival outcomes.
Endoglin (CD105) expression on microvessel endothelial cells in juvenile nasopharyngeal angiofibroma: Tissue microarray analysis and association with prognostic significance
Authors: Wang Jing‐Jing , Sun Xi‐Cai , Hu Li , Liu Zhuo‐Fu , Yu Hua‐Peng , Li Han , Wang Shu‐Yi , Wang De‐Hui 
Published: March 2013

BackgroundThe purpose of this study was to examine endoglin (CD105) expression on microvessel endothelial cells (ECs) in juvenile nasopharyngeal angiofibroma (JNA) and its relationship with recurrence.MethodsImmunohistochemistry was performed to detect CD105 expression in a tissue microarray from 70 patients with JNA. Correlation between CD105 expression on microvessel ECs and clinicopathological features, as well as tumor recurrence, were analyzed.ResultsImmunohistochemistry revealed CD105 expression on ECs but not in stroma of patients with JNA. Chi‐square analysis indicated CD105‐based microvessel density (MVD) was correlated with JNA recurrence (p = .013). Univariate and multivariate analyses determined that MVD was a significant predictor of time to recurrence (p = .009). The CD105‐based MVD was better for predicting disease recurrence (AUROC: 0.673; p = .036) than other clinicopathological features.ConclusionsMVD is a useful predictor for poor prognosis of patients with JNA after curative resection. Angiogenesis, which may play an important role in the occurrence and development of JNA, is therefore a potential therapeutic target for JNA. © 2013 Wiley Periodicals, Inc. Head Neck 35: 1719–1725, 2013
After‐effects of cognitive control on pain
Authors: Silvestrini N. , Rainville P. 
Published: March 2013

AbstractBackgroundThe higher order processes involved in self‐regulation are generally thought to depend on cognitive (attentional/executive) functions with limited resources. Experimental studies further show that exerting self‐control in a first task results in decreased performance in other following self‐control tasks, which may be interpreted as the consequence of either effective or perceived resource depletion outlasting the first task. Given that higher order cognitive/attentional processes are also considered to be involved in pain modulatory mechanisms, we tested the idea that pain could be influenced by prior mobilization of cognitive resources.MethodsThe present study investigated the consequences of performing a cognitively demanding task on subsequent pain (ratings) and spinal nociceptive responses (nociceptive flexion reflex, NFR) elicited by noxious electrical stimulations in healthy volunteers. Participants received four noxious stimulations immediately after each of six successive blocks (2 min each) of a numerical Stroop task in a neutral condition (low cognitive demand) and six successive blocks in an interference condition (high cognitive demand).ResultsResults revealed that pain was rated higher following the condition requiring higher cognitive control. A similar effect was observed on the NFR.ConclusionsThese findings suggest that pain regulation mechanisms including the descending pain modulatory system may be less efficient after the performance of tasks requiring high cognitive control resulting in stronger pain experience.
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:Case Studies in Medical Physiology. Robert S. Alexander.Contemporary Standards for the Pharmacotherapy of Mental Disorders. Jerome Levine, editor.Future Trends in Therapeutics. F. Gilbert McMahon, editor.Current Concepts in Migraine Research. Raymond Greene, editor.2nd International Adalat® Symposium. New Therapy of Ischemic Heart Disease. W. Lochner, W. Braasch, and G. Krongeberg, editors.Heart Function and Metabolism. Recent Advances in Studies on Cardiac Structure and Metabolism, Volume 11. T. Kobayashi, T. Sano, and N. S. Dhalla, editors.
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:Immunodiagnosis of Cancer. Part I. Immunology Series, Vol. 9. R. B. Heberman and K. R. McIntire.Vitamin K Metabolism and Vitamin K‐Dependent Proteins. J. W. SuttieIntracranial Pressure. III. J. W. F. Beks, D. A. Bosch, and M. BrockDrugs and the Elderly: Perspectives in Geriatric Clinical Pharmacology. J. Crooks and I. H. StevensonMicrobiology 1977. D. Schlessinger, editor. Washington, D.C.Toxicity of Heavy Metals in the Environment, Parts 1 and 2. (Hazardous and Toxic Substances Series, Vol. 2). F. W. Oehme
BOOK REVIEWS
Authors: Cavaliere M. Beth 
Published: March 2013

Book reviewed in this article:The Heart (Arteries and Veins) (Sixth Edition) Edited by J. Willis Hurst, MDPharmacology of Eating Disorders: Theoretical and Clinical Developments Edited by Michele O. Carruba and John E. BlundellReviews of Physiology, Biochemistry, and Pharmacology (Volume 102) Edited by R.H. Adrian, et al
Bioavailability of Potassium From Three Dosage Forms: Suspension, Capsule, and Solution
Authors: Melikian Armen P. , Cheng Lawrence K. , Wright George J. , Cohen Albert , Bruce Ruth E. 
Published: March 2013

A crossover study was performed in 28, healthy, male volunteers to determine the bioavailability of potassium from a suspension containing microencapsulated potassium chloride compared with that from a marketed microencapsulated potassium chloride capsule and a marketed potassium chloride solution. The 20‐day study consisted of four, five‐day periods. In three of the periods, a single, 40‐mEq dose of one of the potassium formulations was administered; no drug treatment was given in the remaining period so that the amount of potassium contributed by dietary sources could be determined. Meals were served that provided controlled amounts of potassium and sodium.Bioavailability was represented by cumulative amount of K+ excreted in urine 24 and 48 hours after drug administration. The rate of absorption was calculated from excretion rates during each of the intervals of urine collection on Days 4. The pattern of excretion exhibited by the solution indicated rapid absorption and elimination. The potassium from the suspension and the capsules was excreted more slowly and over a longer period, indicating that the potassium content from these formulations was not being dumped. No statistically significant differences between the suspension and the capsules were found. The extent of absorption of K+ was similar from all three products, and the potassium from the suspension was found to be fully bioavailable when compared with the liquid and the capsule.