bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phototests in Japanese Patients with Papulovesicular Light Eruption: Positive Provocation with UVA
Authors: Torinuki Wakio 
Published: April 2015

AbstractIn six Japanese patients with papulovesicular light eruption (PVLE), photoprovocative tests were performed by irradiating UVA or UVB on the skin of the back on three consecutive days. One patient developed the typical lesion of PVLE at the test site with two consecutive daily irradiations of UVA. The remaining 5 patients had no abnormal phototest reactions. It was obvious that UVA plays an etiological role in at least some cases of PVLE.
Pedunculated Pigmented Eccrine Poroma of the Scalp with Increased Urinary Excretion of 5‐S‐Cysteinyldopa
Authors: Jin Kumi , Nogita Toshitatsu , Toyoda Hiroyuki , Kawashima Makoto , Hidano Akira 
Published: April 2015

AbstractWe describe a 52‐year‐old man with a pedunculated pigmented eccrine poroma mimicking a nodular malignant melanoma in the occipital region. The tumor was once resected but soon recurred.Histologically, the tumor mass extended from the epidermis downwards into the dermis and contained melanin granules in some areas. The tumor cells were uniformly cuboidal in appearance and had round, deeply basophilic nuclei.Initially, the urinary excretion level of 5‐S‐cysteinyldopa (5‐S‐CD) was high, but, after resection of the tumor, the level of 5‐S‐CD returned to normal.
Linear Epidermal Nevus with Acantholytic Dyskeratosis in an Infant
Authors: Yasutomi Hiroshi , Arakawa Kenzo , Akagi Osamu , Miyashita Masato , Arata Jirô 
Published: April 2015

AbstractA 7‐month‐old boy came to us with flat papules and small erosions on the extensor aspect of his left forearm and a linear arrangement of verrucous papules on the dorsum of his left hand. Histological examination revealed hyperkeratosis, parakeratosis, irregular acanthosis, and marked acantholysis from suprabasal through upper epidermis. This is the first reported case of linear epidermal nevus with acantholytic dyskeratosis in Japan.
Laser Medicine and Laser Dermatology
Authors: Parrish John A. 
Published: April 2015

AbstractAs laser devices become smaller, more reliable, and less expensive, dermatology will benefit from new laser‐based therapeutic and diagnostic methods. Already there are simple, non‐scarring, and relatively painless techniques for removal of pigmented lesions, tattoos, and vascular lesions. Because much of the basic and applied research in photobiology is grounded in dermatology research, dermatology will continue to be a major contributor to advances in laser medicine and photomedicine. An increase in understanding and ability to manipulate laser‐tissue interactions will add greatly to the future of medicine and surgery, especially in applications utilizing pulsed lasers. We are learning how to: 1) vary wavelength, pulse duration, and energy to influence the nature of microscopic injury and host response in order to achieve a net therapeutic benefit; 2) utilize exogenous chromophores to increase the selection of targets for laser radiation; and 3) capture optical technology developed for industrial and military use, in order to benefit mankind with new medical and surgical techniques.
Clinical Survey of Syphilis at the Dermatological Clinic of Nippon Medical School Hospital from 1984 to 1988, with Special Reference to the Recent Clinical Manifestations and Evaluation of IgM Antibodies to Treponema pallidum
Authors: Ishinaga Michi , Sasaki Eiko 
Published: April 2015

AbstractOne hundred eighty‐one patients with syphilis were seen from May 1, 1984, to April 30, 1988 at the Dermatological Clinic of Nippon Medical School Hospital. The incidence of syphilis has increased gradually year by year. The number of early infectious syphilis cases was almost twice as high as late latent syphilis ones. As a source of infection, female prostitutes were noteworthy.Among primary syphilis cases, multiple chancres were observed in 29.2%. The frequency of ulcus durum was much higher than initial sclerosis. A relationship with oral sex is suggested. Among secondary syphilis cases, pruritus was observed in 23.9%, prominently on volar lesions. Psoriasiform papular and macular syphilide were the commonest features. Secondary syphilis with persisting chancres were seen in 41.3% and is gradually increasing. JH reactions were observed in 26.3%. The frequency was highest in late primary and in early secondary stages.IgM‐TPHA and IgG‐TPHA were tested in 94 sera by gel‐filtration and 77 by HPLC. IgM‐TPHA tests were reactive in virtually all the sera from untreated syphilis cases. The titres in untreated syphilis were higher than in treated cases. IgM‐TPHA/IgM‐TPHA+IgG‐TPHA was higher in early syphilis than in late syphilis. Fifty‐eight untreated cases were tested at frequent intervals after treatment for up to 12 months. IgM antibodies disappeared in 53 patients within 12 months. Non‐treponemal antibodies measured by the CF test disappeared within 15 patients and TPHA tests remained positive after 12 months in all patients. IgM‐TPHA may support a diagnosis of active syphilis.
Linear IgA Dermatosis and Hodgkin's Lymphoma
Authors: Jacyk Witold Kamil , Nagel Gerhardus Jakobus , van der Hoven Alida Elisabeth 
Published: April 2015

AbstractLinear IgA dermatosis and Hodgkin's lymphoma were diagnosed at the same time in a 47‐year‐old Black South African man. Skin changes of linear IgA dermatosis responded to a combined treatment with dapsone and MOPP regimen. Prior administration of dapsone alone did not result in improvement of the skin condition. Four documented cases of linear IgA dermatosis and lymphoma outside the gastrointestinal tract, three of them of Hodgkin's type, have been reported in the literature. Review of the literature suggests that different forms of lymphoma seem to be associated with linear IgA dermatosis and dermatitis herpetiformis. The present patient represents the first immunologically verified case of linear IgA dermatosis in an adult Black African.
Basal Cell Carcinoma Originating from an Epidermoid Cyst
Authors: Ikeda Isamu , Ono Tomomichi 
Published: April 2015

AbstractBasal cell carcinoma (BCC) originating from an epidermoid cyst which existed for about 50 years was seen in a 78‐year‐old Japanese male. Nests of basal cell carcinoma were connected with the epidermoid cyst, partially replacing the cyst wall.
Unusual Fatty Acid in Sporothrix schenckii
Authors: Yamada Ken‐Ichi 
Published: April 2015

AbstractSporothrix schenckii was isolated from a specimen from a 75‐year‐old woman with lymphatic sporotrichosis on the left forearm. A mass of fungi was cultured in liquid Sabouraud dextrose broth for three months. Crude lipids were extracted from the cultured fungal mass. Total fatty acids and free fatty acids were isolated, purified, and then analyzed using thin‐layer chromatography, gas liquid chromatography, and mass spectrometry. Total fatty acid composition consisted of seven molecular species of C15:0 (2.5%), C16:1 (2.5%), C16:0 (64.5%), 2‐Me‐C16:0 (5.1%), C17:0 (2.0%), C18:1 (18.0%) and C18:0 (5.3%). Free fatty acid composition consisted of eight species of C14:0 (2.0%), C15:1 (4.1%), C16:1 (7.5%), C16:0 (68.5%), C17:0 (0.6%), C18:2 (2.0%), C18:1 (14.5%) and of C18:0 (0.9%). 2‐Me‐C16:0 was detected in the fungus for the first time.
Glycosaminoglycans in Neurofibromas
Authors: Sasaki Tetsuo , Onodera Satoshi 
Published: April 2015

AbstractGlycosaminoglycan (GAG) contents in neurofibromas (NFs) were examined to clarify how well they corresponded to their histological features. Eight cutaneous NFs and three plexiform NFs from five patients with Recklinghausen's (R) disease, two senile NFs, and control dermis were subjected to the isolation of GAGs. The GAGs were then fractionated and quantitated with two‐dimensional electrophoresis on cellulose acetate membranes. Dry weight/wet weight ratios of the NFs were lower than those of the controls; the plexiform NFs were the lowest. In these plexiform NFs, hyaluronic acid (HA) content was most increased and dermatan sulfate (DS) content most decreased, resulting in a marked decrease in the DS/HA ratio. Both cutaneous and senile NFs showed moderate decreases in DS content, increases in chondroitin sulfate and heparan sulfate contents, and slight increases in HA content, resulting in moderate decreases in the DS/HA ratio. Considering that cutaneous or senile NFs are relatively more fibrotic tumors than plexiform NFs, these differences in the GAGs between plexiform NFs and cutaneous or senile NFs appear to be consistent with the changes in GAGs previously described in physiological and pathological conditions such as fibrotic diseases. Thus these results suggest that studies of hereditary disorders like R disease might be useful for understanding the pathogenesis of so‐called acquired diseases with unknown etiology.
Anticonvulsant Syndrome with Multiple Symptoms, Including Porphyria, IgA Deficiency, and Liver Dysfunction
Authors: Ono Tomomichi , Johno Masayoshi , Kayashima Ken‐ichi , Omori Aiko 
Published: April 2015

AbstractA 19‐year‐old Japanese female who had been treated for epilepsy with a combined phenytoin‐phenobarbital preparation for the past three years presented with increasing skin pigmentation and hirsutism. She had suffered two attacks of loss of consciousness after bilateral partial oophorectomy at the age of 16. Investigations revealed a marked increase in coproporphyrin levels in the urine and feces, a marked decrease in her serum IgA level, and liver dysfunction. All these manifestations gradually improved upon the withdrawal of her antiepileptic treatment. In vitro studies revealed B cell dysfunction producing IgA deficiency, which normalized within one year after discontinuation of the antiepileptic therapy. It was assumed that her treatment had worsened preexisting porphyria, which was misdiagnosed as epilepsy because of abnormal EEG findings. The type of porphyria appeared to be hereditary coproporphyria, despite the lack of a family history.
Hair Follicle Nevus with Hyperplasia of Smooth and Striated Muscle
Authors: Kirihara Yoshinobu , Suenaga Yoshinori , Take Nobuaki 
Published: April 2015

AbstractWe report a peculiar nevus which occurred on the left side of the chin of an 18‐year‐old male. It had been present for four years and had grown rapidly during the last year. Histologically, many hair follicles, smooth muscles, and striated muscles were found within the reticular dermis. The hair follicles were accompanied by mature sebaceous glands; numerous eccrine glands were seen in the middle and deep dermis. Immunohistochemical stain and phosphotungstic acid hematoxylin stain supported the fact that the muscles seen between the follicles were both smooth and striated. This nevus was considered to be a hair follicle nevus accompanyed by hyperplasia of smooth muscles and striated muscles.
1α,24R‐Dihydroxyvitamin D3 Has an Ability Comparable to That of 1α,25‐Dihydroxyvitamin D3 to Induce Keratinocyte Differentiation
Authors: Kobayashi Teruaki , Okumura Hidenobu , Azuma Yoshiaki , Kiyoki Mamoru , Matsumoto Kunio , Hashimoto Koji , Yoshikawa Kunihiko 
Published: April 2015

AbstractUsing cultured normal human keratinocytes, we compared the activities of 1α,24R‐dihydroxyvitamin D3 (1,24R(OH)2D3), a synthetic derivative of vitamin D3, and 1α,25‐dihydroxyvitamin D3 (1,25(OH)2D3), a biologically active form, in inducing cell differentiation. Treatment with 10−6 M of 1,24R(OH)2D3 and 1,25(OH)2D3 increased the number of involucrin positive cells (differentiated cells) from 6.4% to 24.1% and 25.1%, respectively. These results indicate that 1,24R(OH)2D3 has an ability comparable to that of 1,25(OH)2D3 to induce cell differentiation in human keratinocytes. The clinical effectiveness of 1,24R(OH)2D3 for the treatment of psoriasis may be, in part, related to its direct effect on hyperproliferative keratinocytes.
Oral Hairy Leukoplakia in AIDS Patients: An Ultrastructural Study
Authors: Manca Vania , Mongiardo Nicola , Pellegrino Francesco , De Rienzo Bruno , Giannetti Alberto 
Published: April 2015

AbstractHairy leukoplakia is a specific oral lesion associated with the opportunistic development of Epstein‐Barr virus in the oral epithelium. It is now considered to be an early sign of HIV‐induced immunosuppression.Four cases of oral hairy leukoplakia (OHL) from the lateral borders of the tongue of male AIDS patients were investigated by transmission electron microscopy. At the ultrastructural level, herpes‐like viral particles were detected in the oral lesions of all cases. Indirect immunofluorescence performed on two cases showed the presence of EBV antigens in the nuclei and the cytoplasm of the infected epithelial cells.None of the specimens contained ultrastructural evidence of human papillomaviruses.
Cutaneous Malignant Lymphoma in an Infant
Authors: Umebayashi Yoshihiro , Nameki Hiromasa , Saito Yoshio , Mori Naoyoshi 
Published: April 2015

AbstractA case of cutaneous malignant lymphoma in a 7‐month‐old infant is described. The skin was the only apparent organ involved. Immunophenotypic studies revealed that the infiltrate was positive for B4 (CD19), J5 (CD10), and cytoplasmic μ chain, and λ chain, but negative for Bl (CD20). The significance of these findings is discussed. We believed the tumor was of B‐cell origin. The reported cases of cutaneous malignant lymphoma in infancy are briefly reviewed.
Epidermal Growth Factor Receptor mRNA Is Not Increased in Psoriatic Skin
Authors: Kobayashi Hitoshi , Yasuda Hidemi , Matsue Hiroyuki , Ohkawara Akira , Ogiso Yoshifumi , Kuzumaki Noboru 
Published: April 2015

AbstractPoly(A)+mRNAs were purified from the skin sheets of five psoriatic patients and three healthy individuals, and mRNA expression of epidermal growth factor (EGF) receptor gene was studied by Northern‐blot technique using a cDNA probe of the whole EGF‐receptor gene. Both psoriatic and normal skin had 5.3‐kb and 11.0‐kb mRNAs of the EGF‐receptor gene. There existed no clear differences in the mRNA levels between psoriasis and normal controls. Since Nanney et al. has reported an increased number of EGF‐receptors in active lesions of psoriasis, it has been speculated that the production of EGF‐receptors is not increased, but rather that the down‐regulation may be decreased, in psoriatic skin, resulting in the increased number of EGF‐receptors.
Cerebrotendinous Xanthomatosis
Authors: Hwang Seon Young , Lee Kwang Hoon , Ahn Jae In 
Published: April 2015

AbstractA case report on a 23‐year‐old female patient with cerebrotendinous xanthomatosis (CTX) is presented. From 8 years of age, the patient clinically showed multiple xanthoma masses on both knees, both heels, and the nasal bridge, juvenile cataracts, multiple abnormal neurologic dysfunctions, and dementia. The level of cholestanol in urine, serum, and xanthoma mass tissues was increased, as determined by capillary gas chromatography.
A Case of Xeroderma Pigmentosum Group D Determined by Photobiological Study
Authors: Ishii Norihisa , Nakajima Hiroshi , Kondo Seiji , Satoh Yoshiaki , Fujiwara Yoshisada , Shimoda Nagayoshi 
Published: April 2015

AbstractA case of xeroderma pigmentosum group D in a 36‐year‐old woman (XP85TO) is reported. The patient had severe photosensitivity from age 4, and developed multiple basal cell epitheliomas and solar keratoses but exhibited no apparent neurological defects. A skin phototest by monochromatic ultraviolet light revealed a delayed peak of erythema 48 h after irradiation and lowered minimal erythemal doses. Unscheduled DNA synthesis induced in XP85TO cells was 36.0% in dermal fibroblasts and 32.6% in epidermal keratinocytes compared with normal cells. The XP85TO cells were sensitive to ultraviolet killing (n=1.0, D0=0.80J/m2). In complementation analysis, XP85TO cells did not complement with xeroderma pigmentosum group D cells. These results indicate that patient XP85TO had xeroderma pigmentosum group D.The Japanese group D patients including XP85TO case showed delayed onset of skin malignant tumors and neurological abnormalities, compared with the group D patients in Europe and the United States. These findings suggest a possible ethnic variation of the clinical phenotype, despite the similar repair defect and ultraviolet hypersensitivity.
Oral Contraceptive‐induced Lupus Erythematosus in a Japanese Woman
Authors: Furukawa Fukumi , Tachibana Takao , Imamura Sadao , Tamura Takashi 
Published: April 2015

AbstractA case of oral contraceptive‐induced lupus erythematosus (LE) was reported. Erythematous skin lesions were noticed on hypothenor sites of palms and acral sites of pedes. Abnormal laboratory findings included an elevated ESR, CRP and weakly positive anti‐nuclear antibodies. Skin biopsy specimens from involved skin showed Clq deposits at the dermo‐epidermal junction.LE‐like symptoms were considered to be induced by oral contraceptives, because her symptoms disappeared after the oral contraceptives were discontinued.
Lymphocyte Response to Staphylococcal Enterotoxin B in Patients with Annular Erythema Associated with Sjögren Syndrome
Authors: Katayama Ichiro , Asai Toshiya , Nishiyama Shigeo , Nishioka Kiyoshi 
Published: April 2015

AbstractLymphocyte response to staphylococcal enterotoxin B (SEB) was analysed in 11 cases with Sjögren syndrome (SjS) who developed annular erythema during the course. Increased lymphocyte response against SEB was observed on day 5 in those patients who developed annular erythema at the time of examination. A similar reaction pattern was observed when Con A and PWM, but not protein A, were used as the mitogen. No significant lymphocyte response was observed in the patients in the inactive stage without annular erythema or in normal controls. Furthermore, peripheral blood lymphocytes express LFA‐1 after SEB stimulation. These results suggest that lymphocytes from SjS patients react to various types of antigenic or mitogenic stimulation and that they express cell adhesion molecules, especially in patients with active annular erythema.
A Novel Anti‐ENA Antibody in Sera of Patients with Childhood Idiopathic Thrombocytopenic Purpura
Authors: Miyagawa Sachiko , Inagaki Yasunori , Okada Natsuko , Yoshioka Akira , Ueki Hiroaki , Yoshikawa Kunihiko , Shirai Toshihiko 
Published: April 2015

AbstractCirculating antibodies against certain extractable nuclear antigens (ENA) have been shown to have diagnostic and prognostic importance in connective tissue diseases. We described here an antibody against ENA found in the sera of patients with idiopathic thrombocytopenic purpura (ITP). The antigen, tentatively called WK according to the patients' initials, was distinct from U1 RNP/Sm, SSA/SSB, Scl‐70, PCNA, PM‐Scl, Jo‐1, and Ku by immunodiffusion. On immunoblotting, the anti‐WK serum recognized polypeptides of 99 kd, 98 kd, and 96 kd in rabbit thymus extracts and a 99 kd polypeptide in KB cell extracts. The anti‐WK antibody was detected in the sera of 2 out of 360 ANA positive patients, both children with clinical features of ITP. One patient developed systemic lupus erythematosus eight years after the onset of ITP.
Biphasic Amyloidosis Arising from Friction Melanosis
Authors: Iwasaki Kazumi , Mihara Motoyuki , Nishiura Seiichi , Shimao Shuhei 
Published: April 2015

AbstractA 40‐year‐old woman who had used nylon towels in the bath for about 10 years noticed hyperpigmentation on the prominent regions over the bones of the trunk and extremities. She also developed lichenoid papules with itching on her back. Histologically, both the pigmented and the papular lesions had amyloid deposits beneath the epidermis. In this case it is presumed that the papular lesions with amyloid (lichen amyloidosus) developed initially from friction melanosis which became macular pigmented lesion (macular amyloidosis). The etiologic factor of these sequential pathologic changes is considered to be repeated scrubbing with nylon towels.
Silica Granuloma: Scanning Electron Microscopy and Energy Dispersive X‐ray Microanalysis
Authors: Chun Soo , Cho Sung Whan 
Published: April 2015

AbstractA 46‐year‐old woman had 1‐month‐old erythematous papules on the left elbow and both knees where acupuncture with gold needles had been performed twenty years earlier. She also had a 2‐month‐old pruritic scar lesion on the nape.Histopathologic findings showed sarcoidal granulomas. The presence of silica components in the granulomas was confirmed by scanning electron microscopy (SEM) of the lesion on the nape and energy dispersive X‐ray microanalysis (EDXA) of the lesions on the nape and the left elbow.We suggest that acupuncture with gold needles may be one cause of silica granuloma.
Abnormal Distribution of Epidermal Protein Antigens in Psoriatic Epidermis
Authors: Watanabe Shinichi , Wagatsuma Keiko , Ichikawa Eiko , Takahashi Hisashi 
Published: April 2015

AbstractThe immunohistochemical distribution of the epidermal proteins filaggrin, involucrin, and cytokeratins is characteristic in normal epidermis. This distribution may change as a result of malignant transformation or abnormal differentiation. The present study was conducted to determine the patterns of reactivity of psoriatic epidermis to antibodies against various epidermal proteins and to clarify abnormal differentiation or maturation of the keratinocytes in psoriatic epidermis.Anti‐human filaggrin, anti‐human involucrin, and twelve kinds of anti‐cytokeratin antibodies were used in this study. Cryostat or paraffin‐embedded sections were stained with these antibodies by the avidin‐biotin peroxidase technique. The epidermis of the noninvolved skin of patients with psoriasis vulgaris showed the distribution seen in normal skin. However, involved psoriatic skin revealed little or no reaction in the stratum corneum or in the granular layer with the anti‐filaggrin antibody. Cells positively staining with anti‐involucrin antibody paradoxically appeared in the lower cell layers of involved psoriatic epidermis. An anti‐keratin antibody, AE1, stained suprabasal cells in involved psoriatic epidermis, although this antibody selectively stained epidermal basal cells in normal skin. The other anti‐keratin antibodies, especially KL1, PKK1, and a polyclonal anti‐keratin antibody, were less reactive with involved psoriatic skin than with normal skin.These observations suggest that the maturation pathway of keratinocytes in active psoriatic lesions differs qualitatively from that in normal epidermis.
Malignant Granular Cell Tumor
Authors: Urabe Atsumichi , Imayama Shuhei , Yasumoto Shinichiro , Nakayama Juichiro , Hori Yoshiaki 
Published: April 2015

AbstractA malignant granular cell tumor (MGCT) appeared on the subungual tissue of the right index finger of a 51‐year‐old woman. Two years after resection of the tumor, it recurred, and the finger finally had to be amputated. Six months later, she noticed multiple cutaneous nodules on her trunk. Despite chemotherapy and X‐ray irradiation, the patient died 18 months after the second operation. Histology of the specimen revealed a proliferation of both polygonal and spindle‐shaped cells with large hyperchromatic nuclei and an eosinophilic granular cytoplasm. Peripheral nerves were encompassed by the tumor cells. Immunohistochemically, the tumor cells were positive for S‐100 protein and Leu 7 (myelin‐associated glycoprotein). These findings support the hypothesis that MGCT cells are of Schwann cell origin.