bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue screening in breast cancer patients: identifying likely cases of cancer‐related fatigue
Authors: Goedendorp Martine M. , Jacobsen Paul B. , Andrykowski Michael A. 
Published: July 2015

AbstractObjectiveFor clinical and research purposes, efficient identification of cases of cancer‐related fatigue (CRF) is important, as CRF can be persistent and interfere with usual functioning. While various fatigue‐screening instruments are available, no brief screening indices have been developed using formally diagnosed CRF cases as the criterion.MethodsBreast cancer patients (n = 385) completed a fatigue diagnostic interview and self‐report fatigue measures (Profile of Mood States‐fatigue subscale, Fatigue Symptom Inventory, and SF‐36 vitality subscale), after initial adjuvant therapy (post‐treatment (post‐Tx) 1 assessment), after completion of radiotherapy for women receiving chemotherapy + radiotherapy (post‐Tx 2 assessment), and 6 months after completion of all adjuvant therapy (6‐month post‐Tx assessment). CRF cases were identified using specific diagnostic criteria. ROC analyses identified screening indices, which could accurately identify CRF cases after initial adjuvant therapy. Screening indices were cross‐validated using post‐Tx 2 and 6‐month follow‐up assessment data.ResultsA total of 104 women (27%) met CRF criteria after initial adjuvant therapy. Six two‐item screening indices were identified. For all indices, area under the curve exceeded 0.80, sensitivity exceeded 0.80, and specificity exceeded 0.57. Cross‐validation suggested that, except for the index based on SF‐36, all the indices continued to accurately identify CRF cases at the post‐Tx 2 and 6‐month post‐Tx assessments. Overall, a two‐item composite index based on Fatigue Symptom Inventory ‘most severity’ and ‘work interference’ items performed best.ConclusionsBreast cancer patients and survivors meeting CRF diagnostic criteria can be accurately identified using brief screening indices derived from common self‐report fatigue measures. Copyright © 2015 John Wiley & Sons, Ltd.
Prolactin‐ and testosterone‐induced carboxypeptidase‐D correlates with increased nitrotyrosines and Ki67 in prostate cancer
Authors: Thomas Lynn N. , Merrimen Jennifer , Bell David G. , Rendon Ricardo , Too Catherine K. L. 
Published: July 2015

BACKGROUNDCarboxypeptidase‐D (CPD) cleaves C‐terminal arginine for conversion to nitric oxide (NO) by nitric oxide synthase (NOS). Prolactin (PRL) and androgens stimulate CPD gene transcription and expression, which increases intracellular production of NO to promote viability of prostate cancer (PCa) cells in vitro. The current study evaluated whether hormonal upregulation of CPD and NO promote PCa cell viabilty in vivo, by correlating changes in expression of CPD and nitrotyrosine residues (products of NO action) with proliferation marker Ki67 and associated proteins during PCa development and progression.METHODSFresh prostate tissues, obtained from 40 men with benign prostatic hyperplasia (BPH) or PCa, were flash‐frozen at the time of surgery and used for RT‐qPCR analysis of CPD, androgen receptor (AR), PRL receptor (PRLR), eNOS, and Ki67 levels. Archival paraffin‐embedded tissues from 113 men with BPH or PCa were used for immunohistochemical (IHC) analysis of CPD, nitrotyrosines, phospho‐Stat5 (for activated PRLR), AR, eNOS/iNOS, and Ki67.RESULTSRT‐qPCR and IHC analyses showed strong AR and PRLR expression in benign and malignant prostates. CPD mRNA levels increased ∼threefold in PCa compared to BPH, which corresponded to a twofold increase in Ki67 mRNA levels. IHC analysis showed a progressive increase in CPD from 11.4 ± 2.1% in benign to 21.8 ± 3.2% in low‐grade (P = 0.007), 40.7 ± 4.0% in high‐grade (P < 0.0001) and 50.0 ± 9.5% in castration‐recurrent PCa (P < 0.0001). Immunostaining for nitrotyrosines and Ki67 mirrored these increases during PCa progression. CPD, nitrotyrosines, and Ki67 tended to co‐localize, as did phospho‐Stat5.CONCLUSIONSCPD, nitrotyrosine, and Ki67 levels were higher in PCa than in benign and tended to co‐localize, along with phospho‐Stat5. The strong correlation in expression of these proteins in benign and malignant prostate tissues, combined with abundant AR and PRLR, supports in vitro evidence that the CPD‐Arg‐NO pathway is involved in the regulation of PCa cell proliferation. It further highlights a role for PRL in the development and progression of PCa. Prostate 75:1726–1736, 2015. © 2015 Wiley Periodicals, Inc.
Properties of near‐surface layer of 64Zn+ ion hot‐implanted Si
Authors: Privezentsev Vladimir , Kulikauskas Vaclav , Steinman Eduard , Tereshchenko Alexey , Bazhenov Anatoly , Tabachkova Nataliya , Batrakov Alexander 
Published: July 2015

AbstractWe have investigated nanoparticles (NPs) formation in Si by 64Zn+ ion implantation at substrate temperature of 350 °C. Hot implantation was chosen to avoid amorphization of Si near‐surface layer. In as‐implanted samples the Zn crystal NPs were created. Then the samples were subsequently subjected to isochronous annealing in oxygen at elevated temperatures. The depth profile of implanted Zn was analyzed by Rutherford backscattering spectroscopy. The dependence of photo‐luminescence spectra on annealing temperatures was observed. In these spectra the peak at 370 nm attributable to ZnO phase and wide peak at 430 nm due to defects were revealed. The visualization and identification of NPs were obtained by transmission electron microscopy and transmission electron diffraction of cross‐section samples. From these study it follows, that after annealing at temperature of 700 °C and higher the NPs with structure of Zn(core)/ZnO · Zn2SiO4(shell) were formed. Auger electron spectroscopy investigation followed the phase content in depth profile was varied from ZnO Zn2SiO4 at a substrate surface to metal Zn in a substrate body. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Treatment of Lateral Epicondylosis by Using Allogeneic Adipose-Derived Mesenchymal Stem Cells: A Pilot Study
Authors: Lee Sang Yoon , Kim Won , Lim Chaiyoung , Chung Sun G. 
Published: July 2015

Abstract
Mesenchymal stem cell therapy is a novel regenerative approach for treating tendinopathy. Here, we evaluated the safety and efficacy of allogeneic adipose-derived mesenchymal stem cells (allo-ASC) in treating lateral epicondylosis (LE). Under ultrasound guidance, allo-ASCs mixed with fibrin glue were injected into the hypoechoic common extensor tendon lesions of 12 participants with chronic LE; 6 subjects each were administered 106 or 107 cells in 1 ml. Safety was evaluated at day 3 and weeks 2, 6, 12, 26, and 52 post-injection. Efficacy was assessed by measuring patients’ visual analog scale (VAS) score for elbow pain, modified Mayo clinic performance index for the elbow, and by evaluating longitudinal and transverse ultrasound images of tendon defect areas after 6, 12, 26, and 52 weeks. No significant adverse effects of allo-ASC injection were observed through 52 weeks of follow-up. From baseline through 52 weeks of periodic follow-up, VAS scores progressively decreased from 66.8 ± 14.5 mm to 14.8 ± 13.1 mm and elbow performance scores improved from 64.0 ± 13.5 to 90.6 ± 5.8. Tendon defects also significantly decreased through this period. Allo-ASC therapy was thus safe and effective in improving elbow pain, performance, and structural defects for 52 weeks. This clinical study is the first to reveal therapeutic value of mesenchymal stem cell injection for treating chronic tendinopathy. Stem Cells 2015;33:2995–3005
Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation
Authors: Raj Deepak , Aicher Alexandra , Heeschen Christopher 
Published: July 2015

AbstractPancreatic cancer stem cells (CSCs) have been first described in 2007 and since then have emerged as an intriguing entity of cancer cells with distinct functional features including self-renewal and exclusive in vivo tumorigenicity. The heterogeneous pancreatic CSC pool has been implicated in tumor propagation as well as metastatic spread. Clinically, the most important feature of CSCs is their strong resistance to standard chemotherapy, which results in fast disease relapse, even with today's more advanced chemotherapeutic regimens. Therefore, novel therapeutic strategies to most efficiently target pancreatic CSCs are being developed and their careful clinical translation should provide new avenues to eradicate this deadly disease. Stem Cells 2015;33:2893—2902
CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming
Authors: Jiang Bo-Hua , Chen Wei-Yi , Li Hsin-Yang , Chien Yueh , Chang Wei-Chao , Hsieh Pei-Chen , Wu Ping , Chen Chieh-Yu , Song Hui-Yung , Chien Chian-Shiu , Sung Yen-Jen , Chiou Shih-Hwa 
Published: July 2015

Abstract
PARP1 and poly(ADP-ribosyl)ation (PARylation) have been shown to be essential for the initial steps of cellular reprogramming. However, the mechanism underlying PARP1/PARylation-regulated activation of pluripotency loci remains undetermined. Here, we demonstrate that CHD1L, a DNA helicase, possesses chromatin remodeling activity and interacts with PARP1/PARylation in regulating pluripotency during reprogramming. We found that this interaction is mediated through the interplay of the CHD1L macro-domain and the PAR moiety of PARylated-PARP1. Chromatin immunoprecipitation assays demonstrated the co-occupancy of CHD1L and PARP1 at Pou5f1, Nanog, and Esrrb pluripotency loci. Knockdown of CHD1L significantly blocked the binding activity of PARP1 at pluripotency loci and inhibited the efficiency of PARP1-driven reprogramming. Notably, we found that CHD1L-promoted reprogramming requires both a PARP1-interacting domain and DNA helicase activity, partly contributing to the chromatin-remodeling states of pluripotency loci. Taken together, these results identify CHD1L as a key chromatin remodeler involved in PARP1/PARylation-regulated early-stage reprogramming and pluripotency in stem cells. Stem Cells 2015;33:2961–2972
Four Metal Complexes Based on Bulky Imidazole Ligands: Solvothermal Syntheses, Crystal Structures, and Fluorescence Properties
Authors: Zhang Xue , Li Sai , He Yue‐Jiao , Han Tong , Wang Xiao‐Ling , Chen Bang , Zou Kang‐Yu , Li Zuo‐Xi 
Published: July 2015

AbstractIn order to explore the influences of (de‐)protonation of the imidazole ring on the structural diversity of the resulting complexes, the imidazole‐based ligands 4, 5‐diphenylimidazole (Hdpi) and 1H‐phenanthro[9, 10‐d]imidazole (Hpi) were utilized as bulky building blocks to construct four complexes by solvothermal reactions, i.e. [Ag(Hdpi)2](NO3)·(H2O) (1), [Cu(dpi)]∞ (2), [Cu(Hpi)(NO3)]∞ (3), and [(H2pi)(NO3)]·H2O (4). In complex 1, two Hdpi ligands adopt a monodentate pattern and coordinate with one AgI ion to form a mononuclear unit, which is further connected by hydrogen bonds into a 1D supramolecular helix. The deprotonated dpi ligand of 2 acts in bidentate mode, and bridges CuI ions to afford a 1D chain. In 3, the NO3– ion, acts as a monodentate bridging ligand and joins CuI ions to generate a 1D chain. The Hpi ligand employs a monodentate mode to bond with CuI ions of the 1D chain. 4 is protonated and two H2pi nitrogen atoms are free of coordination. Interestingly, hydrogen bonds among the NO3– ion, the H2pi ligand, and the water molecule yield a macro ring R44(14). The resulting structural diversity reveals that the (de‐)protonation of imidazole ring directly steers the coordination number of ligand, and thus causes a significant effect on the structure, especially the dimensionality. Furthermore, the solid‐state fluorescence properties of the free ligands and compounds 1–4 were studied at room temperature.
Cultural embeddedness in supply networks
Authors: Wu Zhaohui , Pullman Madeleine E. 
Published: July 2015

AbstractRecent studies on structural and relational embeddedness suggest that favorable position and connections in supply networks benefit a firm. While fruitful, this focus misses the motivations that prompt firms to take economic action in the first place. Understanding cultural embeddedness provides insight into why individuals and firms behave as they do and how their behavior can influence network structure. Contrary to the belief that firms act solely for profit and growth, we note that cultural contents such as values, social issues and political ideologies explain firms’ motives and guide their economic activities. We explore the role of cultural embeddedness through a grounded study of Country Natural Beef, a sustainability‐oriented agricultural cooperative in the western United States. This supply network demonstrates strongly competing cultural claims among its members as well as a unique institutionalized culture. Cultural interactions at the node and network levels explain the functioning of and changes to the network. Through interviews, analysis of archival information and direct observation of pivotal events over a period of 5 years, we unpack cultural embeddedness and take an incremental step toward a theory of cultural embeddedness in cooperative supply networks.
Gap Analysis of Infection Control Practices in Low- and Middle-Income Countries
Authors: Weinshel Kristy , Dramowski Angela , Hajdu Ágnes , Jacob Saul , Khanal Basudha , Zoltán Maszárovics , Mougkou Katerina , Phukan Chimanjita , Inés Staneloni Maria , Singh Nalini 
Published: July 2015

BACKGROUNDHealthcare-associated infection rates are higher in low- and middle-income countries compared with high-income countries, resulting in relatively larger incidence of patient mortality and disability and additional healthcare costs.OBJECTIVETo use the Infection Control Assessment Tool to assess gaps in infection control (IC) practices in the participating countries.METHODSSix international sites located in Argentina, Greece, Hungary, India, Nepal, and South Africa provided information on the health facility and the surgical modules relating to IC programs, surgical antibiotic use and surgical equipment procedures, surgical area practices, sterilization and disinfection of equipment and intravenous fluid, and hand hygiene. Modules were scored for each country.RESULTSThe 6 international sites completed 5 modules. Of 121 completed sections, scores of less than 50% of the recommended IC practices were received in 23 (19%) and scores from 50% to 75% were received in 43 (36%). IC programs had various limitations in many sites and surveillance of healthcare-associated infections was not consistently performed. Lack of administration of perioperative antibiotics, inadequate sterilization and disinfection of equipment, and paucity of hand hygiene were found even in a high-income country. There was also a lack of clearly written defined policies and procedures across many facilities.CONCLUSIONSOur results indicate that adherence to recommended IC practices is suboptimal. Opportunities for improvement of IC practices exist in several areas, including hospital-wide IC programs and surveillance, antibiotic stewardship, written and posted guidelines and policies across a range of topics, surgical instrument sterilization procedures, and improved hand hygiene.Infect. Control Hosp. Epidemiol. 2015;36(10):1208–1214
Reuse of Insulin Pens Among Multiple Patients at 2 Veterans Affairs Medical Centers
Authors: Schirmer Patricia , Winston Carla A. , Lucero-Obusan Cynthia , Winters Mark , Lesse Alan , de Comarmond Charles , Oda Gina , Martinello Richard A. , Holodniy Mark 
Published: July 2015

OBJECTIVETo determine whether reuse of insulin pens among multiple patients resulted in transmission of bloodborne pathogens (BBP).DESIGNRetrospective cohort study.SETTINGTwo Veterans Affairs medical centers.PATIENTSVeterans who received insulin via insulin pens from 2010 to 2013.METHODSPatients were identified through electronic health records, notified of possible exposure, and serotested for human immunodeficiency virus, hepatitis C virus (HCV), and hepatitis B virus. Newly discovered case patients were assessed in relation to potential proximate patients to determine viral strain relatedness by HCV envelope (env) gene sequencing.RESULTSOf 1,791 hospitalized veterans who received insulin via insulin pen, 1,155 were tested for at least 1 viral infection after exposure. Of these, 67 patients were newly diagnosed with 1 or more viral BBPs. For human immunodeficiency virus and hepatitis B virus no additional strain testing of case or proximate patients was possible; 8 HCV cases and 45 proximates (40 unique patients; 5 patients were positive for 2 genotypes) were identified as needing strain testing. Only 3 cases and their 19 proximates had samples available for further testing. None of the 26 remaining proximate patients had blood available for further testing. Median genetic distance between the HCV env sequences of those available for additional testing ranged from 14% to 24%, indicating nonrelatedness.CONCLUSIONSOur investigation revealed that exposure to insulin pen reuse did not result in HCV transmission among patients who had viral genetic analysis performed. Analysis for any additional potential transmission of blood-borne pathogens was limited by the available samples.Infect Control Hosp Epidemiol 2015;36(10):1121–1129
AN ALGEBRA WHOSE SUBALGEBRAS ARE CHARACTERIZED BY DENSITY
Authors: VIGNATI ALESSANDRO 
Published: July 2015

AbstractWe refine a construction of Choi, Farah, and Ozawa to build a nonseparable amenable operator algebra ${\rm {\cal A}}$ ⊆ ℓ∞ (M2) whose nonseparable subalgebras, including ${\rm {\cal A}}$, are not isomorphic to a C*-algebra. This is done using a Luzin gap and a uniformly bounded group representation.Next, we study additional properties of ${\rm {\cal A}}$ and of its separable subalgebras, related to the Kadison Kastler metric.
AXIOM I0 AND HIGHER DEGREE THEORY
Authors: SHI XIANGHUI 
Published: July 2015

AbstractIn this paper, we analyze structures of Zermelo degrees via a list of four degree theoretic questions (see §2) in various fine structure extender models, or under large cardinal assumptions. In particular we give a detailed analysis of the structures of Zermelo degrees in the Mitchell model for ω many measurable cardinals. It turns out that there is a profound correlation between the complexity of the degree structures at countable cofinality singular cardinals and the large cardinal strength of the relevant cardinals. The analysis applies to general degree notions, Zermelo degree is merely the author’s choice for illustrating the idea.I0(λ) is the assertion that there is an elementary embedding j : L(Vλ+1) → L(Vλ+1) with critical point < λ. We show that under I0(λ), the structure of Zermelo degrees at λ is very complicated: it has incomparable degrees, is not dense, satisfies Posner–Robinson theorem etc. In addition, we show that I0 together with a mild condition on the critical point of the embedding implies that the degree determinacy for Zermelo degrees at λ is false in L(Vλ+1). The key tool in this paper is a generic absoluteness theorem in the theory of I0, from which we obtain an analogue of Perfect Set Theorem for “projective” subsets of Vλ+1, and the Posner–Robinson follows as a corollary. Perfect Set Theorem and Posner–Robinson provide evidences supporting the analogy between $$AD$$ over L(ℝ) and I0 over L(Vλ+1), while the failure of degree determinacy is one for disanalogy. Furthermore, we conjecture that the failure of degree determinacy for Zermelo degrees at any uncountable cardinal is a theorem of $$ZFC$$.
EMBEDDINGS OF P(ω)/Fin INTO BOREL EQUIVALENCE RELATIONS BETWEEN ℓp AND ℓq
Authors: YIN ZHI 
Published: July 2015

AbstractWe prove that, for 1 ≤ p < q < ∞, the partially ordered set P(ω)/Fin can be embedded into Borel equivalence relations between ℝω/ℓp and ℝω/ℓq. Since there is an antichain of size continuum in P(ω)/Fin, there are continuum many pairwise incomparable Borel equivalence relations between ℝω/ℓp and ℝω/ℓq.
A STRONG MULTI-TYPED INTUITIONISTIC THEORY OF FUNCTIONALS
Authors: KACHAPOVA FARIDA 
Published: July 2015

AbstractIn this paper we describe an intuitionistic theory SLP. It is a relatively strong theory containing intuitionistic principles for functionals of many types, in particular, the theory of the “creating subject”, axioms for lawless functionals and some versions of choice axioms. We construct a Beth model for the language of intuitionistic functionals of high types and use it to prove the consistency of SLP.We also prove that the intuitionistic theory SLP is equiconsistent with a classical theory TI. TI is a typed set theory, where the comprehension axiom for sets of type n is restricted to formulas with no parameters of types > n. We show that each fragment of SLP with types ≤ s is equiconsistent with the corresponding fragment of TI and that it is stronger than the previous fragment of SLP. Thus, both SLP and TI are much stronger than the second order arithmetic. By constructing the intuitionistic theory SLP and interpreting in it the classical set theoryTI, we contribute to the program of justifying classical mathematics from the intuitionistic point of view.
THE NEXT BEST THING TO A P-POINT
Authors: BLASS ANDREAS , DOBRINEN NATASHA , RAGHAVAN DILIP 
Published: July 2015

AbstractWe study ultrafilters onω2produced by forcing with the quotient of${\cal P}$(ω2) by the Fubini square of the Fréchet filter onω. We show that such an ultrafilter is a weak P-point but not a P-point and that the only nonprincipal ultrafilters strictly below it in the Rudin–Keisler order are a single isomorphism class of selective ultrafilters. We further show that it enjoys the strongest square-bracket partition relations that are possible for a non-P-point. We show that it is not basically generated but that it shares with basically generated ultrafilters the property of not being at the top of the Tukey ordering. In fact, it is not Tukey-above [ω1]<ω, and it has only continuum many ultrafilters Tukey-below it. A tool in our proofs is the analysis of similar (but not the same) properties for ultrafilters obtained as the sum, over a selective ultrafilter, of nonisomorphic selective ultrafilters.
MAD SPECTRA
Authors: SHELAH SAHARON , SPINAS OTMAR 
Published: July 2015

AbstractThe mad spectrum is the set of all cardinalities of infinite maximal almost disjoint families on ω. We treat the problem to characterize those sets ${\rm {\cal A}} $ which, in some forcing extension of the universe, can be the mad spectrum. We give a complete solution to this problem under the assumption $\vartheta &#x5e;{ &#x3c; \vartheta } &#x3d; \vartheta $, where $\vartheta &#x3d; {\rm{min}}\left( {\rm {\cal A}} \right) $.