bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical Specification and Bid Evaluation: Major Bottlenecks in Equipment Procurement in a Public Sector Tertiary Care Hospital
Authors: Prabhakar Shweta , Singhal AK , Vardhan Shikha 
Published: February 2015

ABSTRACT

Introduction
The innovation of modern medical equipment with wide diversity has contributed immensely in improving the quality of healthcare and state of health profile of nations. For effective and efficient control on procurement of medical equipment, it is required to control the lead time (internal) as limited scope exists in case of external lead time.

Objectives
The study was conducted to analyze the lead time with an aim to identify the issues/bottlenecks and to suggest the appropriate remedial measures in a public sector Tertiary care Hospital.

Materials and methods
A retrospective exploratory study was undertaken. A total of 50 such capital equipment was procured in this hospital during March 2007 to 2010 (3 years) were included in this study.

Results
It was observed that the procurement procedure in public sector tertiary care hospital is as per the standard guidelines prescribed by Government of India in General Financial Rules and guidelines issued by MOHFW and DGHS in this regard. The lead time analysis showed that there is a variation in the total lead time, internal lead time (ILT), external lead time (ELT) and their components. It was observed that ILT2 and ILT4 component constituted around 70% of the total ILT for almost all the equipments under study. In case of ELT, 75% time was consumed by ELT1, i.e. the delivery time and receipt of equipment.

Conclusion
Since activities in both ILT2 and ILT4, i.e. laying down the technical specification and bid evaluation are the responsibility of the individual department, the overall delay can also be attributed to the individual departments. This is in contrast to the general impression that there is delay on the part of purchase department. On an analysis of lead time as per VED category, it has been concluded that no concept of VED analysis is applied in the procurement of equipment. On further analysis of lead time analysis, it was concluded that the shortest time was taken by proprietary purchase followed by open tender and maximum time in open tender where approval from higher authority was required.

How to cite this article
Prabhakar S, Singhal AK, Vardhan S. Technical Specification and Bid Evaluation: Major Bottlenecks in Equipment Procurement in a Public Sector Tertiary Care Hospital. Int J Res Foundation Hosp Healthc Adm 2014;2(2): 103-110.
Planning and Designing of a Sleep Center
Authors: Kant Sunil , Gupta Shakti Kumar , Singh Madhav Madhusudan , Patnaik Saroj Kumar , Chandrasekhar R 
Published: February 2015

ABSTRACT
Sleep disorders have become very common in today's world. The various sleep related disorders are increasing at an alarming proportion. The first sleep clinics in the United States were established in the 1970s by interested doctors and technicians; sleep centers are specialized centers where an individual is provided home like environment and surroundings and his sleep cycle is monitored. Active therapeutic and diagnostic interventions are also done here. This article discusses various planning and designing issues of sleep center.

How to cite this article
Patnaik SK, Gupta SK, Kant S, Chandrasekhar R, Singh MM. Planning and Designing of a Sleep Center. Int J Res Foundation Hosp Healthc Adm 2014; 2(2):117-120.
The Consumer Protection Act: A Review of Legal Perspective
Authors: Kapoor Pawan , Singh Madhav Madhusudan , Patnaik Saroj , Chaturvedi Manu , Srivastava Pradeep 
Published: February 2015

ABSTRACT
The fast pace of commercialization and globalization is affecting all spheres of life, the medical profession is also affected by this socioeconomic phenomena. The consumer protection act (CPA) enacted in 1986 intended to provide effective and efficient safeguards to the consumers against various types of exploitations and unfair practices. This review article aims to augment awareness of medical practitioners regarding CPA and how to prevent litigations.

How to cite this article
Singh MM, Patnaik S, Kapoor P, Chaturvedi M, Srivastava P. The Consumer Protection Act: A Review of Legal Perspective. Int J Res Foundation Hosp Healthc Adm 2014;2(2):121-129.
Internet Control or Internet Censorship? Comparing the Control Models of China, Singapore, and the United States to Guide Taiwan’s Choice
Authors: Li Jeffrey (Chien-Fei) 
Published: February 2015

Internet censorship refers to a government’s unjustified scrutiny and control of online speech or government-approved control measures. The danger of Internet censorship is its chilling effect and substantial harm on free speech, a cornerstone of democracy, in cyberspace. This article compares China’s blocking and filtering system, Singapore’s class license system, and the United States’ government-private partnership model and identifies the features of each model. This article also explores the pros and cons of each model under international human rights standards. By finding lessons from each of the models, this article contends that Taiwan should retain its current minimal Internet control model. Further, Taiwan should fix flaws in its current Internet control system, including the private partnership model adopted by the Copyright Act, to be consistent with Article19.3 of the ICCPR.
Enhanced Performance of CsPbBr3 Nanocrystals via Dual Passivation
Authors: Sun Yujiao , Cheng Yongchao , Yang Zijiang , Bian Ce , Huang Sheng , Gu Xiuquan 
Published: August 2024

AbstractPerovskite CsPbBr3 nanocrystals show excellent optical properties. However, the nanocrystals encounter a major challenge of poor stability. In this study, an effective approach is proposed for enhancing the stability of CsPbBr3 nanocrystals via a dual passivation strategy, where the dual passivation layer is composed of alumina (Al2O3) and polymer ethylene‐vinyl acetate (EVA). The Al2O3 coating on the CsPbBr3 surface is realized by in situ oxidation of trimethyl aluminum (TMA), which passivated the surface defects while blocking the intrusion of water and oxygen. The EVA film is formed by a solution method, which can further block the water and oxygen, and form the flexible composite with perovskite CsPbBr3 nanocrystals with enhanced stability toward water and heat. After soaking for 360 h and heating for 5 h, the photoluminescence (PL) intensity is higher than that without passivation. The polymer EVA packaging strategy provided CsPbBr3 with excellent extensibility and flexibility at 100% and 200% tensile rates, the PL intensity remains 91% and 88% of the initial intensity, which returns to the initial value after stretching. The unique dual‐protection structure significantly improves the water and thermal stability of the nanocrystals. The strategy might point out the direction for the future application of perovskites.
Contrasting Facial Selectivity of a Squaramide‐Tagged Proline in the Asymmetric Michael Addition of Ketones to Maleimides
Authors: Kumari Kiran , Khan Akram Gulam Hussain , Easwar Srinivasan 
Published: August 2024

AbstractA squaramide moiety was introduced at the C‐4 position of proline to afford an organocatalyst that served as a stereocontrol element to promote the asymmetric Michael addition of cyclic ketones to maleimides. A variety of chiral succinimides were obtained by the conjugate addition in 84–98% yield accompanied by 58–96% enantioselectivity. The results also include an interesting contrast in the facial selectivity observed with cyclohexanones and cycloheptanones, whereas an asymmetric desymmetrization of 4‐alkyl cyclohexanones was also achieved using the transformation.
Locus of Control and Mental Health: Human Variation Complicates a Well‐Established Research Finding
Authors: Kaiser Bonnie N. 
Published: August 2024

ABSTRACTIntroductionLocus of control (LoC) refers to one's expectation that life outcomes and (mis)fortune are driven largely by one's own actions or abilities (internal LoC) or by external factors (e.g., powerful others, chance; external LoC). There is a large literature demonstrating an association between internal LoC and positive mental health outcomes. However, this research is conducted mostly in high‐income, Global North settings, with limited consideration of cross‐cultural variability. This short report explores how LoC relates to mental health when considered in a less‐studied context: in a setting of stark structural violence and in relation to supernatural agents.MethodsI conducted a community‐based survey in rural Haiti (n = 322) that assessed sent spirit‐related locus of control (LoC‐S) and mental health.ResultsAmong individuals experiencing higher levels of daily stressors, depressive and anxiety symptoms were high regardless of LoC‐S. However, for individuals facing low‐to‐moderate daily stressors, external LoC‐S (believing one does not have control in relation to sent spirits) was associated with lower depressive and anxiety symptoms, though this interaction did not hold for anxiety after controlling for covariates. Though initially a nonintuitive finding, I contextualize this outcome in relation to ethnographic work in Haiti, showing that the ability to explain misfortune via the supernatural world can serve as a form of blame displacement.ConclusionIn a context where extreme structural violence means that individuals realistically have little control over their lives, an external LoC better reflects lived experience, helping explain the association with better mental health outcomes.
Salivary cortisol captures endocrine response to an acute stressor in captive female tufted capuchin monkeys (Sapajus apella)
Authors: DeSana Andrew N. , Morgan Benowitz‐Fredericks Z. , Amano Aiko , Gazes Regina P. 
Published: August 2024

AbstractMeasuring glucocorticoids such as cortisol is a useful tool for exploring relationships among behavior, physiology, and well‐being in primates. As cortisol circulates in blood, it moves into biological matrices such as hair, urine, feces, and saliva. Saliva sampling is a simple, noninvasive method to measure cortisol that can be easily implemented by training animals to voluntarily provide samples. The temporal lag between elevation of cortisol in the blood and elevation of cortisol in saliva likely varies by species and must be characterized to identify appropriate sampling regimens. In the present study we characterized the time course of cortisol changes in saliva following an acute psychological stressor in captive tufted capuchin monkeys (Sapajus apella). We trained eight free‐moving female tufted capuchin monkeys to voluntarily produce clean saliva samples. We exposed them to the acute stressor of a veterinary catch net and observed behavior pre and post exposure. We collected salivary samples immediately pre exposure (0 min) and 30, 45, 60, 75, 90, and 120 min after exposure. Salivary cortisol was quantified using a Salimetrics kit. Behavioral and cortisol measures were compared within individuals to a control condition in which no stressor was presented. Capuchins showed a clear behavioral response to the stressor by demonstrating increased freezing and pacing, decreased feed foraging, nonsocial play, and scratching, and decreased willingness to provide saliva samples after stressor presentation. After stressor presentation, average salivary cortisol began to increase at 30 min and continued to increase through the 120 min sample period. There was individual variation in absolute cortisol levels, the timing of the cortisol increase, and the timing of the peak. Our results suggest that no single time‐point can be reliably used to evaluate salivary cortisol response to an acute stressor across individuals, and instead we recommend the collection of a prolonged time series.
The Simplified Quantum Circuits for Implementing Quantum Teleportation
Authors: Zhang Wen‐Xiu , Song Guo‐Zhu , Wei Hai‐Rui 
Published: August 2024

AbstractIt is crucial to design quantum circuits as small as possible and as shallow as possible for quantum information processing tasks. Quantum circuits are designed with simplified gate‐count, cost, and depth for implementing quantum teleportation among various entangled channels. Here, the gate‐count/cost/depth of the Greenberger‐Horne‐Zeilinger‐based quantum teleportation is reduced from 10/6/8 to 9/4/6, the two‐qubit‐cluster‐based quantum teleportation is reduced from 9/4/5 to 6/3/5, the three‐qubit‐cluster‐based quantum teleportation is reduced from 12/6/7 to 8/4/5, the Brown‐based quantum teleportation is reduced from 25/15/17 to 18/8/7, the Borras‐based quantum teleportation is reduced from 36/25/20 to 15/8/11, and the entanglement‐swapping‐based quantum teleportation is reduced from 13/8/8 to 10/5/5. Note that, no feed‐forward recover operation is required in the simplified schemes. Moreover, the experimentally demonstrations on IBM quantum computer indicate that the simplified and compressed schemes can be realized with good fidelity.
Identification of Novel Target DCTPP1 for Colorectal Cancer Therapy with the Natural Small‐Molecule Inhibitors Regulating Metabolic Reprogramming
Authors: Feng Li , Wang Xinjia , Guo Xinrui , Shi Liyuan , Su Shihuang , Li Xinjing , Wang Jia , Tan Ninghua , Ma Yi , Wang Zhe 
Published: August 2024

AbstractColorectal cancer (CRC) is one of the most common malignant tumors. Identification of new effective drug targets for CRC and exploration of bioactive small‐molecules are clinically urgent. The human dCTP pyrophosphatase 1 (DCTPP1) is a newly identified pyrophosphatase regulating the cellular nucleotide pool but remains unexplored as potential target for CRC treatment. Here, twelve unprecedented chemical architectures terpene‐nonadride heterodimers (1–12) and their monomers (13–20) were isolated from endophyte Bipolaris victoriae S27. Compounds 1–12 represented the first example of terpene‐nonadride heterodimers, in which nonadride monomers of 1 and 2 were also first example of 5/6 bicyclic nonadrides. A series of assays showed that 2 could repress proliferation and induce cell cycle arrest, apoptotic and autophagic CRC cell death in vitro and in vivo. Clinical cancer samples data revealed that DCTPP1 was a novel target associated with poor survival in CRC. DCTPP1 was also identified as a new target protein of 2. Mechanically, compound 2 bound to DCTPP1, inhibited its enzymatic activity, intervened with amino acid metabolic reprogramming, and exerted anti‐CRC activity. Our study demonstrates that DCTPP1 was a novel potential biomarker and therapeutic target for CRC, and 2 was the first natural anti‐CRC drug candidate targeting DCTPP1.
Metal‐Phenolic Nanomaterial with Organelle‐Level Precision Primes Antitumor Immunity via mtDNA‐dependent cGAS‐STING Activation
Authors: Tian Hao , Li Wenxi , Wang Guohao , Tian Ye , Yan Jie , Yu Xinying , Yan Ziliang , Feng Yuzhao , Dai Yunlu 
Published: August 2024

AbstractNew generation of nanomaterials with organelle‐level precision provide significant promise for targeted attacks on mitochondria, exhibiting remarkable therapeutic potency. Here, we report a novel amphiphilic phenolic polymer (PF) for the mitochondria‐targeted photodynamic therapy (PDT), which can trigger excessive mitochondrial DNA (mtDNA) damage by the synergistic action of oxidative stress and furan‐mediated DNA cross‐linking. Moreover, the phenolic units on PF enable further self‐assembly with Mn2+ via metal‐phenolic coordination to form metal‐phenolic nanomaterial (PFM). We focus on the synergistic activation of the cGAS‐STING pathway by Mn2+ and tumor‐derived mtDNA in tumor‐associated macrophages (TAMs), and subsequently repolarizing M2‐like TAMs to M1 phenotype. We highlight that PFM facilitates the cGAS‐STING‐dependent immunity at the organelle level for potent antitumor efficacy.
In‐Situ Dynamic Carburization of Mo Oxide with Unprecedented High CO Formation Rate in Reverse Water‐Gas Shift Reaction
Authors: Du Xiangze , Li Rongtan , Xin Hui , Fan Yamei , Liu Chengxiang , Feng Xiaohui , Wang Jianyang , Dong Cui , Wang Chao , Li Dan , Fu Qiang , Bao Xinhe 
Published: August 2024

AbstractIn situ construction of active structure under reaction conditions is highly desired but still remains challenging in many important catalytic processes. Herein, we observe structural evolution of molybdenum oxide (MoOx) into highly active molybdenum carbide (MoCx) during reverse water‐gas shift (RWGS) reaction. Surface oxygen atoms in various Mo‐based catalysts are removed in H2‐containing atmospheres and then carbon atoms can accumulate on surface to form MoCx phase with the RWGS reaction going on, both of which are enhanced by the presence of intercalated H species or Pt‐dopants in MoOx. The structural evolution from MoOx to MoCx is accompanied by enhanced CO2 conversion, which is positively correlated with the surface C/Mo ratio but negatively with the surface O/Mo ratio. As a result, an unprecedented CO formation rate of 7544.6 mmol ⋅ gcatal−1 ⋅ h−1 at 600 °C has been achieved over in situ carbonized H‐intercalated MoO3 catalyst, which is even higher than those from noble metal catalysts. During 100 h stability test only a minimal deactivation rate of 2.3 % is observed.
Redox‐Inducible Radiomimetic Photosensitizers Selectively Suppress Cancer Cell Proliferation by Damaging DNA through Radical Cation Chemistry
Authors: Fan Heli , Wang Luo , Zeng Xuanwei , Xiong Chenghe , Yu Dehao , Zhang Xiaofan , Chen Jiayi , Meng Zhaowei , Campbell Anahit , Huang Wanqiao , Mei Hui , Sun Huabing 
Published: August 2024

AbstractRadiotherapy leverages ionizing radiation to kill cancer cells through direct and indirect effects, and direct effects are considered to play an equal or greater role. Several photosensitizers have been developed to mimic the direct effects of radiotherapy, generating radical cations in DNA models, but none has been applied in cellular studies. Here, we design a radiomimetic photosensitizer, producing DNA radical cations in cells for the first time. To reduce adverse effects, several redox‐inducible precursors are prepared as cancer cells have elevated levels of GSH and H2O2. These precursors respond to GSH or H2O2, releasing the active photosensitizer that captures DNA abasic (AP) sites and generates DNA radical cations upon photolysis, without disrupting the redox state of cells. DNA radical cations migrate freely and are eventually trapped by H2O and O2 to yield DNA lesions, thus triggering DNA damage response. Our study suggests that direct effects of radiotherapy suppress cancer cell proliferation mainly by inducing G2/M phase cell cycle arrest, rather than promoting apoptosis. Synergistic effects of the precursor and chemotherapeutic agents are also observed in combination phototherapy. Beyond highlighting an alternative strategy for phototherapy, this proof‐of‐concept study affords a facile cellular platform to study the direct effects of radiotherapy.
Improving Active Site Local Proton Transfer in Porous Organic Polymers for Boosted Oxygen Electrocatalysis
Authors: Zhao Qian , Zhang Qingxin , Xu Yuhan , Han Anhao , He Haowen , Zheng Haoquan , Zhang Wei , Lei Haitao , Apfel Ulf‐Peter , Cao Rui 
Published: August 2024

AbstractImproving proton transfer is vital for electrocatalysis with porous materials. Although several strategies are reported to assist proton transfer in channels, few studies are dedicated to improving proton transfer at the local environments of active sites in porous materials. Herein, we report on new Co‐corrole‐based porous organic polymers (POPs) with improved proton transfer for electrocatalytic oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). By tuning the pore sizes and installing proton relays at Co corrole sites, we designed and synthesized POP‐2‐OH with improved proton transfer both in channels and at local Co active sites. This POP shows remarkable activity for both electrocatalytic ORR with E1/2=0.91 V vs RHE and OER with η10=255 mV. Therefore, this work is significant to present a strategy to improve active site local proton transfer in porous materials and highlight the key role of such structural functionalization in boosting oxygen electrocatalysis.
Nanomole Scale Screening of Fluorescent RNA‐Methyltransferase Probes Enables the Discovery of METTL1 Inhibitors
Authors: Meidner J. Laurenz , Frey Ariane F. , Zimmermann Robert A. , Sabin Mark O. , Nidoieva Zarina , Weldert Annabelle C. , Hoba Sabrina N. , Krone Mackenzie W. , Barthels Fabian 
Published: August 2024

AbstractRNA methylation is a metabolic process validated for its association with various diseases, and thus, RNA methyltransferases (MTases) have become increasingly important in drug discovery. Yet, most frequently utilized RNA MTase assays are limited in their throughput and hamper this rapidly evolving field of medicinal chemistry. In this study, we describe a modular nanomole scale building block system that allowed the identification of tailored fluorescent MTase probes to unlock a broad selection of MTase drug targets for fluorescence‐based binding assays. Probe candidates were initially prepared on a 4 nanomole scale and could be tested directly from crude reaction mixtures to allow rapid probe identification and optimization. Using an alkyne‐azide click late‐stage functionalization strategy and in silico protein databank mining, we established a selection of fluorescent probes suitable for relevant drug targets from the METTL and NSUN families, as well as bacterial and viral MTases. Using this concept, a high‐throughput screening on the unexplored drug target METTL1 discovered three hit compounds with micromolar potency providing a (1H‐pyrazol‐4‐yl)pyridine‐based starting point for METTL1 drug discovery.
Selective Coupling of β‐(Borylvinyl)silanes by a Gold‐Catalyzed Hiyama Reaction—An Easy Way to Diaryl‐Substituted Vinyl Boronates
Authors: Zhang Shan , Wunsch Jonas F. , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: August 2024

AbstractThe use of diaryl‐substituted vinyl boronates, a class of chemical building blocks with well‐known synthetic utility, is principally limited by the difficulty faced in their preparation. Herein, we present a convenient synthetic strategy based on a gold‐catalyzed Hiyama arylation of (Z)‐β‐(borylvinyl)silanes, which are easily accessible by hydroboration of silylalkynes. By exploiting the highly electronegative nature of the gold(III) intermediate (which is accessed by light‐assisted oxidation using aryl diazonium salts), a selective activation of the silyl group in the presence of the boron moiety is achieved. This opens a route to selectively synthesize diaryl‐substituted vinyl boronates. The reaction shows a broad substrate range, excellent functional group tolerance, and perfect chemoselectivity. Experimental studies and density functional theory (DFT) calculations allowed us to elucidate the mechanism of the reaction. The synthetic potential was demonstrated by downstream transformations providing a facile route to bifunctional phenanthrenes and triaryl‐substituted olefins.
Enamine Synthesis via Regiocontrolled 6‐endo‐dig and 5‐exo‐dig Tethered Carboamination of Propargylic Alcohols
Authors: Solé‐Àvila Helena , Puriņš Mikus , Eichenberger Lucas , Waser Jerome 
Published: August 2024

AbstractEnamines are versatile building blocks for the synthesis of biologically active compounds. Nevertheless, only a limited number of strategies have been reported for preparing trisubstituted enamines in a regio‐ and stereoselective manner. Herein, we report a regiocontrolled 6‐endo and 5‐exo tethered carboamination of propargylic alcohols for the synthesis of trisubstituted enamines. High regioselectivity was achieved through fine‐tuning of the amine protecting group during the Pd‐catalyzed carboamination. The introduced trifluoromethylated tether enables further stereoselective functionalizations, such as hydrogenation and fluorination.