bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increases in resilience and school performance among elementary school‐aged afterschool participants
Authors: Longhi Dario , Brown Marsha , O'Connor Becca 
Published: August 2024

AbstractElementary‐school students enrolled in a trauma‐informed program participated in a prepost longitudinal study of resilience. The study assesses increases in various components of resilience, the effects of the afterschool program on resilience, and the relationship between resilience and school performance. A shortened version of a reliable resilience survey was developed from Madsen Thompson's Trauma Resilience Scale and administered at students' entry and exit from 3 yearly sessions. The high response rate provided a sample of 103 students, 37 of whom were new students with no ceiling effects. Statistical analysis demonstrated that both contextual and individual resilience increased significantly, with protective components impacting one another. Regression analyses found that the afterschool program supports significantly affected individual resilience increases, and high levels of individual resilience led to increases in school performance. The results suggest that trauma‐informed contextual supports may be useful in increasing young students' well‐being and closing gaps in academic performance.
Oncogenic tRNA‐derived fragment tRF‐Leu‐CAG promotes tumorigenesis of lung cancer via targeting TCEA3 and increasing autophagy
Authors: Wu Fan , Chai Binshu , Qi Pengfei , Han Yaqi , Gu Zhitao , Pan Wei , Zhang Hui , Wang Xianyi , Liu Xiaomin , Zou Heng , Liang Chen , Li YanLi , Fang Wentao , Ma Zhongliang 
Published: August 2024

AbstractBackgroundLung cancer is a prevalent and severe form of malignant tumors worldwide. tRF‐Leu‐CAG, a recently discovered non‐coding single‐stranded small RNA derived from transfer RNA, has sparked interest in exploring its biological functions and potential molecular mechanisms in lung cancer.MethodsThe abundance of tRF‐Leu‐CAG was measured via quantitative real‐time polymerase chain reaction (qRT‐PCR) in 96 sets of lung cancer tissue samples obtained from clinical patients. Subsequently, both in vivo and in vitro experiments were conducted to validate the biological functions of tRF‐Leu‐CAG in lung cancer. Furthermore, an exploration of the potential target genes of tRF‐Leu‐CAG and its association with autophagy and drug resistance in lung cancer was undertaken.ResultsOur analysis revealed a significant upregulation of tRF‐Leu‐CAG in non‐small cell lung cancer (NSCLC) tissues. Additionally, we observed that heightened expression of tRF‐Leu‐CAG significantly augmented the proliferation and migration of NSCLC cells, facilitated cell cycle progression, and suppressed apoptosis. Furthermore, we identified transcription elongation factor A3 (TCEA3) as a direct target gene of tRF‐Leu‐CAG. TCEA3 inhibited the proliferation and migration of NSCLC, and tRF‐Leu‐CAG promoted the proliferation and migration of NSCLC by mediating the silencing of TCEA3. Moreover, we demonstrated that the augmentation of paclitaxel resistance by tRF‐Leu‐CAG was contingent on autophagy. Finally, tRF‐Leu‐CAG notably accelerated tumor growth and promoted the process of epithelial‐mesenchymal transition (EMT) in vivo.ConclusionstRF‐Leu‐CAG promotes NSCLC tumor growth and metastasis by targeting TCEA3 and promotes paclitaxel resistance by enhancing cellular autophagy. These results provide potentially effective targets and therapeutic options for the clinical treatment of NSCLC.
Integrating behavior and organizational change literatures to uncover crucial psychological mechanisms underlying the adoption and maintenance of organizational change
Authors: Kamarova Sviatlana , Gagné Marylène , Holtrop Djurre , Dunlop Patrick D. 
Published: August 2024

SummaryImplementing successful organizational change is challenging, and to better understand it, researchers and practitioners have proposed a variety of models of change management. Paradoxically, while the behavior change of organizational members lies at the core of organizational change, theories and models of behavior change are rarely applied to organizational change management. Such knowledge could improve our understanding of underlying psychological mechanisms behind organizational change adoption and maintenance. Using self‐determination theory as the framework, we developed a model of organizational change that integrates knowledge across the organizational and behavior change fields by (i) unifying change practices derived from organizational change models and from behavior change techniques, (ii) identifying and unifying underlying psychological mechanisms derived from theories that explain how organizational and behavior change occurs, and (iii) linking change practices to psychological mechanisms. The resulting model aims to provide theoretical and practical guidance for those involved in the planning and implementation of organizational change.
Pork cuts, hams, and sausages have digestible indispensable amino acid scores (DIAAS) close to or over 100
Authors: Fanelli Natalia S. , Martins Juliana C. F. R. , Stein Hans H. 
Published: August 2024

AbstractBackgroundThe “Digestible Indispensable Amino Acid Score” (DIAAS) method measures protein quality in human foods. Animal‐based products generally have high protein quality, but DIAAS values for some pork products are not available. Therefore, the objective of this experiment was to determine standardized ileal digestibility (SID) of amino acids (AA) and DIAAS values for pork products, including three types of pork cuts, Italian hams, and sausages, and to test the hypothesis that all pork products have DIAAS equal to or greater than 100.ResultsThe mean SID of the indispensable AA in all pork products was above 90% and indicated excellent digestibility. For children from 6 months to 3 years old and individuals older than 3 years, prosciutto had greater (p < 0.05) DIAAS than all other pork products. Tenderloin and Coppa had greater (p < 0.05) DIAAS than back ribs, shoulder butt, chorizo, and bratwurst. There were no limiting AA in any of the pork products (DIAAS >100) with the exception that sulfur AA (SAA: methionine + cysteine) were limiting in chorizo for children from 6 months to 3 years old (DIAAS = 99).ConclusionWith the exception of chorizo for children less than 3 years old, all pork products have “excellent” protein quality for individuals older than 6 months of age, with DIAAS greater than 100. Pork proteins can, therefore, complement proteins with low quality to produce a meal that is adequate in all AA.
Unpacking the complexity of cultural distance in inbound and outbound tourism: A case‐oriented approach
Authors: Zhang Ziang , So Kevin Kam Fung , Li Jing , Olya Hossein , Huang Zhenfang 
Published: August 2024

AbstractDue to limitations in mainstream symmetric methodologies, the linkages between cultural dimensions and tourism demand have yet to be fully understood. Drawing on Hofstede's theory of national culture and adopting the asymmetric and case‐oriented fuzzy‐set qualitative comparative analysis method, this investigation explored configuration models of cultural distance between 65 countries in relation to China's inbound and outbound tourism flows. Using a series of three studies, this research assessed the impact of grouping Hofstede's six cultural distance dimensions and the effect of cultural distance as a whole on Chinese inbound and outbound tourism flows within the cultural, administrative, geographic, and economic distance framework. Findings indicate that several paths respectively lead to high inbound and outbound tourism flows. Uncertainty avoidance and long‐term orientation are core conditions for high inbound and outbound tourism flows, respectively. Three testable propositions were additionally evaluated by comparing cultural distance configurations between high inbound and outbound tourism flows.
Wellness and Wanderlust: How Social Wellness Impacts Travel Motivation
Authors: Jo Hyeon 
Published: August 2024

ABSTRACTWith the emergence of wellness as a significant lifestyle consideration, its influence on various life aspects, including travel, is gaining attention. This study aims to explore the intricate relationship between social wellness, physiological needs, safety‐security needs, self‐actualization needs, and travel intention. Utilizing partial least squares structural equation modeling (PLS‐SEM), the research examined these connections within a sample of 317 respondents. Findings revealed that social wellness significantly influence physiological needs, which in turn, have a strong positive effect on safety‐security needs, self‐actualization needs, and travel intention. However, safety‐security needs were not found to directly impact travel intention. Income was the only control variable affecting travel intention, with gender, age, and timing of last travel showing no significant influence. These insights carry valuable theoretical contributions, enriching the understanding of wellness‐driven travel motivation and offering practical implications for service providers, marketers, and policymakers in the travel and tourism industry.
Mucosal Injection of the Silicon Phthalocyanine Pc 4 in a Rabbit Model—A Pilot Study
Authors: Patel Nilam , Held Isabel , Trzcinska Anna , Wasman Jay , Alagramam Kumar N. , Oleinick Nancy L. , Maronian Nicole , Howard Nelson S. 
Published: August 2024

ObjectiveThe silicon phthalocyanine Pc 4 is a photosensitizing agent previously shown to be a promising treatment for cutaneous neoplasms using photodynamic therapy (PDT). Based on prior preclinical studies, we believe Pc 4‐PDT has potential as a targeted treatment of human recurrent respiratory papillomatosis or laryngeal leukoplakia by direct injection into mucosal surfaces.MethodsThis was a proof‐of‐concept pilot study assessing direct mucosal injection of Pc 4 into buccal and vocal fold mucosae in a rabbit model. Five New Zealand white rabbits underwent tattooing of bilateral buccal mucosae to delineate injection sites, followed by submucosal injections of control and Pc 4 solutions. Rabbits were monitored for post‐injection tolerance. Punch biopsies were obtained from injected mucosa and assessed histopathologically. Once the buccal mucosa was found to be tolerant, vocal folds of three rabbits were injected. The rabbits were then sacrificed, and laryngeal tissue was assessed histopathologically.ResultsAll rabbits tolerated injection of Pc 4 and control solutions into buccal mucosa with no evidence of gross visual inflammatory changes and no changes in behavior or masticatory function. Histopathologic analysis of Pc 4 injected buccal and control mucosal tissue revealed mild focal histological changes and no stigmata of diffuse inflammatory reactions. The histopathologic analysis of Pc 4 injected into laryngeal tissue revealed similar findings with addition of mild eosinophilia in one sample.ConclusionDirect mucosal injection of Pc 4 in rabbit buccal and vocal fold mucosae appears to be well tolerated with no gross inflammatory changes, and only mild histopathologic inflammatory changes observed.Level of EvidenceNA Laryngoscope, 2024
Multiscenario simulation of fallow schemes in China and their impact on food security
Authors: Zeng Siyan , Chen Fu , Ma Jing , Liu Gang‐Jun , Wanger Thomas Cherico 
Published: August 2024

AbstractA sound fallow program may potentially reduce food production and hence farmers' income in the short term but can help mitigate farmland pollution, improve food productivity, and enhance ecological protection in the long term. In China, degrading quality of arable land, soil pollution, and groundwater overexploitation require urgent implementation of suitable fallow schemes. We used existing spatial factors influencing the implementation of fallow schemes (including the delineated ecological protection red lines [EPRL], soil pollution, groundwater overexploitation, and arable land quality), and determined farmers' willingness to fallow to understand priority areas of fallow in China under multi‐scenario simulation. Results show that of all farmers willing to fallow, only 2.17% of farmers actively participated in a fallow scheme. Compared to other factors determining fallow implementation, our multi‐scenario simulation found that: (1) scales of the high fallow scheme exhibit a descending order of PES (priority to ecological security scenario, 20.58%) > MCL (minimum production capacity loss scenario, 19.52%) > PFW (priority to farmers' willingness scenario, 18.98%) > PFS (priority to food safety scenario, 15.30%) and that (2) the loss of grain production capacity in implementation of the high fallow scheme is PES (17.32%) > PFW (14.36%) > PFS (13.66%) > MCL (9.67%). We recommend that the implementation of the fallow program at a national level should consider farmers' willingness to participate in a fallow scheme, the loss of food production capacity in the short term, as well as the mitigation of arable land pollution, the improvement of ecological protection, and the safeguard of global food security in a long term.
The Effect of Apis mellifera L. Pollination on Seed Yield and Nutritional Qualities of Sesamum indicum L. in Dale Sedi District of Western Oromia, Ethiopia
Authors: Tesfaye Ofijan , Gaisa Elias 
Published: August 2024

ABSTRACTThe development of blossoming seed plants that provide a genetically diverse crop of progeny depends on pollination. Sesamum indicum is an oilseed crop and requires both self and cross‐pollination that varies based on insect type, crop variety, and environmental factors. Hence, the experiment was conducted for two consecutive years (2022 and 2023) to the effect of Apis mellifera L. pollination on yield, germination, and nutritional qualities of S. indicum (Dicho variety). A completely randomized block design with three treatments was used, and each treatment was replicated four times. Insects from open plot were counted from 1 m × 1 m quadrant/5 min. Seed yield and yield parameters and germination rates were recorded based on standard methods. Oil content was analyzed by Soxhlet extraction. From the study, 13 insects were identified of which 69.2% were categorized under the order Hymenoptera. A combined mean of plant height, branch/plant, and number of pod/plant showed statistically no difference (p > 0.05) among treatments. However, the number of seeds/pod, 1000 seed weight, and yield (quintal)/ha produced by an open plot and a plot caged with A. mellifera were statistically higher (p < 0.05) as compared with the closed plot. The percentage increment in seed yield (quintal)/ha were 17.16% and 20.33% for the open plot and the plot caged with bees, respectively. The seed germination was found to be maximum in the open plot (88.9%) followed by a plot caged with A. mellifera (86.68%) and a closed plot (60.46%). A measurable variation (p < 0.05) in oil content(%) was recorded among the treatments with the maximum from a plot caged with bees (54.24 ± 0.27) followed by an open plot (52.04 ± 0.58) and closed plot (48.81 ± 0.24). These findings suggest that pollinators, including honey bees, A. mellifera visiting S. indicum can enhance yields, germination rates, and oil content.
Quantitative Comparisons of Progressive Supranuclear Palsy Rating Scale Versions Using Item Response Theory
Authors: Gewily Mohamed , Plan Elodie L. , Yousefi Elham , König Franz , Posch Martin , Hopfner Franziska , Höglinger Günter , Karlsson Mats O. 
Published: August 2024

AbstractBackgroundProgressive supranuclear palsy (PSP) is a neurodegenerative, late‐onset disease that is challenging in terms of assessment. The Progressive Supranuclear Palsy Rating Scale (PSPRS), a 28‐item clinician‐reported scale, is the most established clinical outcome assessment method. Recently, the U.S. Food and Drug Administration (FDA) has proposed a subscale of 10 items as an alternative to full PSPRS.ObjectivesTo quantitatively evaluate and compare the properties of full PSPRS and the FDA subscale using item response theory. To develop a progression model of the disease and assess relative merits of study designs and analysis options.MethodsData of 979 patients from four interventional trials and two registries were available for analysis. Our investigation was divided into: (1) estimating informativeness of the 28 items; (2) estimating disease progression; and (3) comparing the scales, trial designs, and analysis options with respect to power to detect a clinically relevant treatment effect.ResultsPSPRS item scores had a low pairwise correlation (r = 0.17 ± 0.14) and the items irritability, sleep difficulty, and postural tremor were uncorrelated with the other items. The FDA‐selected items displayed higher correlation (r = 0.35 ± 0.14) and were the basis for a longitudinal item response model including disease progression. Trial simulations indicated that identification of a disease‐modifying treatment effect required less than half the study size if the analysis was based on longitudinal item information compared with total scores at end‐of‐treatment.ConclusionA longitudinal item response model based on the FDA‐selected PSPRS items is a promising tool in evaluating treatments for PSP. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Thrombotic Consequences of COVID‐19 Infection on Microsurgical Reconstruction
Authors: Han Sabrina H. , Ockerman Kyle , Kirchmier Matthew , Mardourian Markos , Bryan Jaimie , Cox Elizabeth , Chim Harvey , Spiguel Lisa , Momeni Arash , Sorice‐Virk Sarah 
Published: August 2024

ABSTRACTBackgroundEvidence has shown increased morbidity and mortality for patients with COVID‐19 infection within 7 weeks of surgery. However, no studies have specifically investigated the effects of COVID‐19 in microsurgical outcomes. This study evaluated thrombotic and overall complications after free tissue transfer for a variety of indications in patients with and without previous COVID‐19 infection.MethodsA retrospective cohort study was performed in adult patients with or without a history of COVID‐19 infection who underwent microsurgical reconstruction between 2017 and 2022. Patients with a history of COVID‐19 infection were matched to controls based on age, gender, race, body mass index, history of diabetes, coronary artery disease, hypertension, Caprini score, tobacco use, and flap indication.ResultsFrom 2017 to 2022, 35 patients had a documented history of COVID‐19. Matched case analysis determined a 4.8 times increased odds ratio of postoperative complications in the COVID‐19 group compared with controls (p = 0.002). Significantly, more patients with COVID‐19 experienced total or partial flap loss and anastomotic issues (COVID‐19: 7/35, Control: 0/35; p < 0.001). There was no significant difference in incidence of VTE (COVID‐19: 1/35, Control: 0/35; p = 0.493). Of note, 62.9% of the COVID‐19 group were discharged on anticoagulants (versus 14.3% in the control group [p < 0.001]).ConclusionCOVID‐19 has dire, long‐lasting effects on virtually every organ system, chief among them, the microcirculation. Further studies are needed to fully determine the extent and influence of COVID‐19 on complex procedures such as free tissue transfer and how to optimize the screening, workup, and postoperative care to guard against the associated thrombotic consequences.
Garlic Extract Promotes Pancreatic Islet Neogenesis Through α‐to‐β‐Cell Transdifferentiation and Normalizes Glucose Homeostasis in Diabetic Rats
Authors: Al‐Adsani Amani M. , Al‐Qattan Khaled K. , Barhoush Sahar A. , Abbood Manal S. , Al‐Bustan Suzanne A. 
Published: August 2024

ScopeGarlic extract (GE) has been shown to ameliorate hyperglycemia in diabetic rats (DRs) by increasing insulin production. However, the mechanism through which it exerts its effects remains unclear. Here, it investigates the molecular process and the origin of regenerating β‐cell in rats with streptozotocin (STZ)‐induced diabetes in response to GE.Methods and resultsIn this study, quantitative RT‐PCR (qRT‐PCR), western blotting, and immunohistochemical analysis are carried out after pancreas isolation. These findings show that 1 week of GE treatment increases the expression of the endocrine progenitor cell markers Neurogenin3 (Neurog3), pancreatic and duodenal homeobox 1 (Pdx1), neurogenic differentiation factor 1 (Neurod1), paired box proteins (Pax)4, V‐maf musculoaponeurotic fibrosarcoma oncogene homolog B (Mafb), and NK homeobox factors (Nkx)6‐1 in STZ‐induced DRs. Continuation with GE treatment for 8 weeks causes the expression of the mature β‐cell markers insulin(Ins)2, urocortin3 (Ucn3), and glucose transporter 2 (Glut2) to peak. Comprehensive examination of the islet through immunohistochemical analysis reveals the presence of a heterogeneous cell population including INS+/GLUT2− and INS+/GLUT2+ β‐cell subpopulations with few bihormonal INS+/GCG+ cells after 4 weeks. By week 8, islet architecture is reestablished, and glucose‐stimulated insulin secretion was restored through the upregulation of Ucn3.ConclusionGE induces β‐cell neogenesis in DRs and restores islet architecture. The newly formed mature β‐like cells could have originated through the differentiation of endocrine progenitor cells as well as α‐ to β‐cell transdifferentiation.
Design of wideband bandpass frequency selective surface based on the patch resonators and substrate integrated waveguide cavities
Authors: Liu Qianwen , Zhou Ying , Li Bo , Lyu Yun‐peng 
Published: August 2024

AbstractIn this paper, a new approach for the design of wideband bandpass frequency selective surface (FSS) is proposed based on the microstrip patch resonator and substrate integrated waveguide (SIW) cavity. Originating from the similarity of field distributions between the patch and SIW resonators, the patch resonator is concentrically embedded within the SIW cavity. In this context, resonant modes in both patch resonator and SIW cavity can be generated without enlarging the circuit size. Then, the slotlines are introduced to the ground layer to establish cross‐couplings to produce transmission zeros (TZs) for better out‐of‐band performances. For demonstration, a fourth‐order bandpass FSS is constructed, simulated, and fabricated. The measured results agree with the simulated ones, verifying that the proposed design method possesses attractive advantages of low profile, compact size, high frequency selectively, and nice universality.