bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work‐related Stress and Urinary Catecholamines among Laboratory Technicians
Authors: Ghaddar Ali , Omar Kayan Hajj , Dokmak Maha , Kansour Nadine Abou , Jbara Zeina , Laham Sandy , Samaha Ali 
Published: July 2013

Work‐related Stress and Urinary Catecholamines among Laboratory Technicians: Ali GHADDAR, et al. Observatory of Public Policies and Health, Center Bonmarche, Lebanon—ObjectivesWork‐related psychosocial hazards are associated with adverse health outcomes among workers. The association between psychosocial hazards and physiological health outcomes among laboratory technicians has not been studied previously. The objective of this study was to measure the association between work‐related psychosocial hazards and the level of urinary catecholamines of laboratory technicians.MethodsThe Copenhagen Psychosocial Questionnaire was distributed to a sample of 125 workers in one community in Lebanon (response rate 73%) to measure psychosocial hazards. High‐pressure liquid chromatography (HPLC) was used to measure adrenaline, noradrenaline and dopamine in 24‐hour urine samples.ResultsSensorial demands, insecurity at work, influence at work and low possibilities of development were particularly high among the workers. Linear regression analysis showed that sensorial and quantitative demands and low possibilities for development increased the levels of urinary catecholamines.Discussionthe results suggest important policy implications for laboratory administrations regarding improvement of the exposure of workers to sensorial and quantitative demands and low possibilities for development as a way to improve worker health.
Neoadjuvant Paradigm for Accelerated Drug Development: An Ideal Model in Bladder Cancer
Authors: Chism David D. , Woods Michael E. , Milowsky Matthew I. 
Published: July 2013

Learning Objectives
Describe how pathological complete response predicts for improved outcome in patients with MIBC. Explain the biological rationale for neoadjuvant chemotherapy in MIBC related to the dysregulation in PI3K/AKT, RAF/MEK/ERK signaling pathways, and ERBb family.
Microstructural characterisation of oxide layer developed by sulphuric anodisation on 2017A alloys
Authors: Fares Chahinez , Boudiaf Achraf , Belouchrani Mohamed El Amine , Boukharouba Taoufik 
Published: July 2013

Abstract
In this paper, the characteristics of the oxide film formed on the surface of 2017A aluminium alloy by sulphuric oxidation are investigated. Morphological features on the oxide film are studied using scanning electron microscopy. Crystallographic details are obtained using X-ray diffraction. The composition of the oxide layer is estimated using wavelength dispersive X-ray spectrometry and Raman spectroscopy. Through systematic structure–property studies, the microstructure of the oxide layer is identified providing the incorporation of the alloying elements in the inner layer with a copper enrichment at the interface.
Les « points de contact » entre anthropologie et performance
Authors: Schechner Richard , Pecorari Marie 
Published: July 2013

L’article interroge la pertinence actuelle des six points de contact entre théâtre et anthropologie définis en 1985 par l’auteur, Richard Schechner. À l’aide d’outils critiques caractéristiques de l’hybridité disciplinaire des Performance Studies (anthropologie, médecine, histoire), il envisage comme performances des pratiques rituelles dites « indigènes » et préhistoriques représentatives d’un « savoir incarné » délaissé ou déformé par le cadrage positiviste des sciences occidentales, et plaide pour une adaptation méthodologique à cet objet.
Jerk , de Gisèle Vienne et Jonathan Capdevielle
Authors: Barbéris Isabelle 
Published: July 2013

Performance solo inspirée d’une nouvelle de Denis Cooper et mettant en jeu les techniques du « corps-castelet » et de la ventriloquie, Jerk est la reconstitution corporelle d’un fait divers américain des années 1970, l’inscription sur un corps de plusieurs scènes de crime devant une fiction d’auditoire théorique. En glissant de la marionnette à la ventriloquie, le spectacle met en scène une défiguration des personnages à l’intérieur du « corps-caméra » (Catherine Perret) du performeur.
2D and 3D imaging of a buried prehistoric canoe using GPR attributes: a case study
Authors: Zhao Wenke , Tian Gang , Wang Bangbing , Forte Emanuele , Pipan Michele , Lin Jinxin , Shi Zhanjie , Li Xuejing 
Published: July 2013

ABSTRACTWe apply Ground Penetrating Radar (GPR) to detect a prehistoric canoe at the Maoshan site, Zhejiang Province, China. A complex attribute analysis of the GPR data allows enhancing the precision in target detection and provides more details about the canoe and the burial environment. The burial depth of the bottom interface of the prehistoric canoe is detected and the integrity of the whole canoe is assessed through a GPR survey. Difficulties in the application of dense sampling of 2D and pseudo 3D GPR data originate from micro‐topographical disturbance that specifically affects the pseudo 3D investigation results obtained from high‐frequency antennas. Data processing and advanced imaging techniques can only remove part of such effects. The research demonstrates that GPR can successfully image wooden cultural relics buried in the shallow subsurface with ultra, high‐density trace spacing and high‐frequency antennas even in totally saturated clay‐rich soils based on 2D profiles and pseudo 3D methodologies, characterized by tight (cm) cross‐line/in‐line spacing.
Motivated word formation and (mis)understanding
Authors: English Kathryn 
Published: July 2013

L’étude des groupes nominaux denses qui caractérisent la langue de spécialité et leur organisation constitue le gros du travail des terminologues. Mais les termes, une fois identifiés, étiquetés et rendus monosémiques sont-ils les garants d’une compréhension objective de la réalité technique ? Cet article examine la question par l’étude du point de vue, la motivation métaphorique des termes, la logique des arbres terminologiques et la fonction de la définition.
« L’âme pense-t-elle toujours ? » Postérité de la théorie de l’intensio et remissio formarum dans la querelle entre empiristes et cartésiens
Authors: Simonetta David 
Published: July 2013

« Le bon sens est la chose du monde la mieux partagée. » Il n’est
pas rare de voir dans l’incipit du Discours de la méthode un de ces
énoncés cartésiens qui, par leur simplicité et leur transparence,
marquèrent une rupture avec la technicité de la philosophie
scolastique des siècles précédents. Pourtant, à se pencher sur les
commentaires qui ont été produits de ce texte, dès sa publication, il
apparaît que pour un certain nombre de contemporains de Descartes, il
y avait là une référence à la théorie dite de l’intensio et remissio
formarum – ou latitude des formes – qui, de Pierre Lombard à
Nicolas d’Oresme en passant par Richard de Middleton, fit l’objet de
discussions soutenues pendant plus de six siècles. Cette théorie
énonce que seules les qualités accidentelles sont susceptibles de
variations intensives dans une substance, contrairement aux propriétés
essentielles qui, elles, sont invariables. L’énoncé de Descartes, aux
atours de simple proverbe, cacherait en réalité un tour de force
argumentatif : tenant pour acquis que la pensée constitue l’attribut
essentiel de l’âme, Descartes mobiliserait la théorie de l’intensio et remissio
formarum pour affirmer qu’en chaque âme, cette pensée n’est pas
susceptible de plus et de moins. Il devient alors possible de définir
certaines opérations épistémiques élémentaires qui s’observent à part
égale en chacun de nous, et ne sont pas soumises à la variabilité des
compétences individuelles.Mais ce point d’interprétation du texte
de Descartes ne conserverait qu’un intérêt herméneutique s’il ne
trouvait, outre-Manche et quelques dizaines d’années plus tard, un
remarquable rebondissement : En 1690, John Locke, dans L’Essai sur l’entendement humain, identifie
parfaitement la référence médiévale sous-jacente à cet énoncé
canonique du cartésianisme, et la discute avec la plus grande rigueur.
En indexant la pensée sur l’attention, et en remarquant que cette
attention est susceptible de variations d’intensités au cours du
temps, Locke en vient à se demander s’il ne faut pas renoncer au
postulat cartésien selon lequel la pensée constituerait l’essence de
l’âme, et lui préférer l’hypothèse selon laquelle cette pensée ne
serait pour l’âme qu’une activité.
Trichostatin A Enhances Differentiation of Human Induced Pluripotent Stem Cells to Cardiogenic Cells for Cardiac Tissue Engineering
Authors: Lim Shiang Y. , Sivakumaran Priyadharshini , Crombie Duncan E. , Dusting Gregory J. , Pébay Alice , Dilley Rodney J. 
Published: July 2013

Abstract
Human induced pluripotent stem (iPS) cells are a promising source of autologous cardiomyocytes to repair and regenerate myocardium for treatment of heart disease. In this study, we have identified a novel strategy to enhance cardiac differentiation of human iPS cells by treating embryoid bodies (EBs) with a histone deacetylase inhibitor, trichostatin A (TSA), together with activin A and bone morphogenetic protein 4 (BMP4). Over a narrow window of concentrations, TSA (1 ng/ml) directed the differentiation of human iPS cells into a cardiomyocyte lineage. TSA also exerted an additive effect with activin A (100 ng/ml) and BMP4 (20 ng/ml). The resulting cardiomyocytes expressed several cardiac-specific transcription factors and contractile proteins at both gene and protein levels. Functionally, the contractile EBs displayed calcium cycling and were responsive to the chronotropic agents isoprenaline (0.1 μM) and carbachol (1 μM). Implanting microdissected beating areas of iPS cells into tissue engineering chambers in immunocompromised rats produced engineered constructs that supported their survival, and they maintained spontaneous contraction. Human cardiomyocytes were identified as compact patches of muscle tissue incorporated within a host fibrocellular stroma and were vascularized by host neovessels. In conclusion, human iPS cell-derived cardiomyocytes can be used to engineer functional cardiac muscle tissue for studying the pathophysiology of cardiac disease, for drug discovery test beds, and potentially for generation of cardiac grafts to surgically replace damaged myocardium.
Sustained Release of Bone Morphogenetic Protein 2 via Coacervate Improves the Osteogenic Potential of Muscle-Derived Stem Cells
Authors: Li Hongshuai , Johnson Noah Ray , Usas Arvydas , Lu Aiping , Poddar Minakshi , Wang Yadong , Huard Johnny 
Published: July 2013

Abstract
Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes and chondrocytes and enhance bone and articular cartilage repair in vivo, a feature that is not observed with nontransduced MDSCs. These results emphasize that MDSCs require prolonged exposure to BMPs to undergo osteogenic and chondrogenic differentiation. A sustained BMP protein delivery approach provides a viable and potentially more clinically translatable alternative to genetic manipulation of the cells. A unique growth factor delivery platform comprised of native heparin and a synthetic polycation, poly(ethylene argininylaspartate diglyceride) (PEAD), was used to bind, protect, and sustain the release of bone morphogenetic protein-2 (BMP2) in a temporally and spatially controlled manner. Prolonged exposure to BMP2 released by the PEAD:heparin delivery system promoted the differentiation of MDSCs to an osteogenic lineage in vitro and induced the formation of viable bone at an ectopic site in vivo. This new strategy represents an alternative approach for bone repair mediated by MDSCs while bypassing the need for gene therapy.
Development of an In‐house Endoanal Ultrasound Teaching Phantom
Authors: Shobeiri S. Abbas , Rostaminia Ghazaleh , Shobeiri Hediyeh 
Published: July 2013

ObjectivesThe aim of this study was to construct an anatomically correct phantom for visualization of anal sphincter complex structures.MethodsTo make an endoanal ultrasound phantom, we experimented with a variety of commercially available materials to simulate hyperechoic, hypoechoic, and isoechoic tissue consistency. We created external anal sphincter muscle and the levator plate using stand‐alone density gel and microbubbles to simulate the echogenicity of the muscles. A mold was created in a container, the muscles were inserted, and the mold was filled with high‐density clear gel and allowed to fill. Once finished, the container was sealed tightly and stored for later use. To evaluate the accuracy of the model, 6 ultrasound imaging raters from different disciplines were included. The raters were administered a 6‐item Internet‐based interactive test using 2‐dimensional images obtained from scanning the phantom. Rater agreement was determined. The Fleiss κstatistic was calculated to determine inter‐rater reliability.ResultsThe raters identified the structures in 32 (89%) of 36 test questions. There was good to excellent agreement among the readers. Agreement rates for visualization of the external anal sphincter, perineal body, and internal anal sphincter were 67%, 83%, and 100%, respectively.ConclusionsAn endoanal phantom can be constructed as a simulator for endoanal sonography.
Does Computed Tomography Have Any Additional Value After Sonography in Patients With Suspected Acute Appendicitis?
Authors: Koo Hye Soo , Kim Hyun Cheol , Yang Dal Mo , Kim Sang Won , Park Seong Jin , Ryu Jung Kyu 
Published: July 2013

ObjectivesThe purpose of this study was to evaluate the additional value of supplementary computed tomography (CT) after sonography for diagnosing acute appendicitis.MethodsAmong 140 consecutive patients with suspected acute appendicitis who underwent both initial sonography and supplementary CT within 12 hours, 88 patients whose appendices could not be visualized on sonography were excluded. The remaining 52 patients (mean age, 37.3 years; range, 15–98 years) were enrolled in this study. Two radiologists retrospectively reviewed the findings of 52 sonographic and CT examinations, and the appendix of each patient was classified as normal, equivocal appendicitis, nonperforated acute appendicitis, or perforated appendicitis. Causes of right lower quadrant pain other than appendicitis were also recorded. The additional value of supplementary CT was evaluated by performing head‐to‐head comparisons between CT and sonographic results.ResultsNo patients with a normal appendix on sonography showed appendicitis on CT. In addition, there were no patients with a sonographic diagnosis of appendicitis who had a normal appendix on CT. Ten patients (19.2%) were determined to have additional value gained from CT. Among these 10 patients, however, the additional information from CT affected treatment modality decisions in only 5.ConclusionsInitial sonography can be as effective as CT in patients with suspected acute appendicitis when the results are definite. Supplementary CT should only be performed when sonography is inconclusive.
Osteogenic Differentiation of Human Adipose‐Derived Stem Cells Can Be Accelerated by Controlling the Frequency of Continuous Ultrasound
Authors: Kang Kyung Shin , Hong Jung Min , Kang Jo A. , Rhie Jong-Won , Cho Dong-Woo 
Published: July 2013

ObjectivesThe purpose of this study was to demonstrate that the effects of continuous ultrasound on the osteogenic differentiation of human adipose‐derived stem cells (hASCs) are dependent on the frequency in vitro.MethodsBefore stimulation, we characterized the hASCs using cluster of differentiation marker profiles and tridifferentiation. Then we selected effective frequencies in the range of 0.5 to 1.5 MHz (with a peak negative pressure of 52 kPa), which upregulated runt‐related transcription factor 2 messenger RNA expression. Next, the effects of ultrasound at the selected frequencies on the osteogenic differentiation were evaluated at the protein level. Alkaline phosphatase activity and the formation of mineralized nodules were measured. We additionally identified the cellular mechanisms underlying the effects of ultrasound stimulation using Western blotting.ResultsThe hASCs showed general cluster of differentiation marker profiles of stem cells and confirmed their potentials to yield adipogenic, chondrogenic, and osteogenic differentiation. Frequencies of 0.5, 1.0, and 1.5 MHz were selected for higher runt‐related transcription factor 2 expression in the range of 0.5 to 1.5 MHz. Among the 3 groups, alkaline phosphatase activity and the formation of mineralized nodules were increased in cells exposed to 1.5‐MHz ultrasound compared with cells exposed to 0.5‐or 1.0‐MHz ultrasound and nontreated control cells. We additionally confirmed that this acceleration of osteogenic differentiation was related to p38 and protein kinase B signaling pathways.ConclusionsIn this study, we found that, in the selected range, 1.5 MHz was the most effective frequency for inducing the osteogenic differentiation of hASCs.
Reference Ranges and Distribution of Placental Volume by 3‐Dimensional Virtual Organ Computer‐Aided Analysis Between 11 Weeks and 13 Weeks 6 Days
Authors: Guyomard Aurélie , Macé Guillaume , Ferdynus Cyril , Franceschini Carole , Rousseau Thierry , Sagot Paul 
Published: July 2013

ObjectivesThe purpose of this study was to determine the feasibility, reproducibility, and distribution of placental volume measurements according to the crown‐rump length between 11 weeks and 13 weeks 6 days.MethodsImages were acquired in 128 pregnancies followed in Burgundy during first‐trimester screening sonography using an abdominal 3‐dimensional transducer. The placental volume was then calculated by the virtual organ computer‐aided analysis method with a rotation angle of 30° by a single operator.ResultsPlacental volumes ranged from 33.3 to 107.6 cm3 with a mean ± SD of 62.3 ± 14.8 cm3; the 5th and 10th percentiles were 38.0 and 44.20 cm3, respectively, whereas the 90th and 95th percentiles were 80.25 and 86.68 cm3. An exponential relationship was found between placental volume and crown‐rump length: ln placental volume = 0.018 × crown‐rump length + 2.93425; ln SD = 0.15; r2 = 0.58. Finally, the mean placental quotient, defined as the ratio of placental volume to crown‐rump length, was 1 ± 0.1 cm3/mm; the respective percentile values were 0.74, 0.81, 1.18, and 1.29 cm3/mm. No associations were found between parity or smoking and the placental quotient or between obesity and the placental quotient. Intraobserver reproducibility was good, with a mean difference of 0.2 cm3.ConclusionsMeasurement of placental volume between 11 weeks and 13 weeks 6 days is reliable and reproducible and correlates strongly with crown‐rump length.
Distress and drinking: Cross-cultural connections and contexts
Authors: Wilsnack Richard , Kristjanson Arlinda F. , Wilsnack Sharon C. , Benson Perry W. 
Published: July 2013

Wilsnack, R., Kristjanson, A. F., Wilsnack, S. C. & Benson, P. W. (2012). Distress and drinking: Cross-cultural connections and contexts. International Journal of Alcohol and Drug Research, 1(1), 79-94. doi: 10.7895/ijadr.v1i1.37 (http://dx.doi.org/10.7895/ijadr.v1i1.37)Aims: Research on how distress is related to drinking has paid relatively little attention to gender and to cultural differences. This study examines how distress is associated with men’s and women’s drinking cross-culturally.Design: Cross-sectional survey.Setting/Participants: Surveys of 30,728 women and 24,204 men in 22 countries of the GENACIS project (Gender, Alcohol and Culture: An International Study) provided data on how women’s and men’s mental, interpersonal and work-situational distress are related to their drinking patterns.Measurements: Analyses examined correlations within surveys, and used hierarchical linear modeling (HLM) to take into account economic development, abstinence rates and distress levels in the populations surveyed.Findings: We found few associations of drinking patterns with reported stressful work situations. Mental and interpersonal distress had more frequent but geographically scattered associations with men’s and women’s drinking, particularly with quantities consumed. HLM analyses confirmed cross-culturally that drinking tended to increase with psychological and interpersonal distress, but the societal-level variables had few effects.Conclusions: Distress measures in GENACIS surveys were positively though not powerfully associated with both women's and men's drinking cross-culturally, associations not attributable to societal-level characteristics. The findings indicate a need for better cross-cultural information about the processes by which distress may lead to heavier drinking.
Why do we need another journal?
Authors: Rehm, IJADR Advisory Board Chair Jürgen , Pollock, VP Research, CAMH Bruce G. 
Published: July 2013

(no abstract)Rehm, J. & Pollock, B. G. (2012). Why do we need another journal? International Journal of Alcohol and Drug Research, 1(1), 9-10. doi: 10.7895/ijadr.v1i1.54 (http://dx.doi.org/10.7895/ijadr.v1i1.54)
A call to support the new KBS journal
Authors: Parry, IJADR Advisory Board Charles D.H. 
Published: July 2013

(no abstract)Parry, C. D. H. (2012). A call to support the new KBS journal. International Journal of Alcohol and Drug Research, 1(1), 7. doi: 10.7895/ijadr.v1i1.56 (http://dx.doi.org/10.7895/ijadr.v1i1.56)
Toward new comparative understandings
Authors: Stenius, IJADR Advisory Board Kerstin 
Published: July 2013

(no abstract)Stenius, K. (2012). Toward new comparative understandings. International Journal of Alcohol and Drug Research, 1(1), 11. doi: 10.7895/ijadr.v1i1.69 (http://dx.doi.org/10.7895/ijadr.v1i1.69)
A hybrid gradient‐based and differential evolution algorithm for infinite impulse response adaptive filtering
Authors: Yuenyong Sumeth , Nishihara Akinori 
Published: July 2013

SUMMARYGlobal optimization algorithms (GO) had been applied to solve the adaptive infinite impulse response filtering problem, which is known to have multimodal error surface under certain conditions. However, although GO may be able to search multimodal surfaces, they have certain disadvantages. They may not converge to any minimum point, the convergence speed is reduced as the solution vectors move closer, and tracking ability for non‐stationary environment is lacking. The traditional gradient descent method does not have these limitation but is not able to search multimodal surfaces. In this work, we propose a hybrid algorithm combining gradient descent and differential evolution (DE) for adapting the coefficients of infinite impulse response adaptive filters. DE is run in a block‐based manner. The coefficient vector with the lowest error surface value (the best member) of the current block is updated via gradient descent for the duration of the next block. Thus combining the ability to search multimodal surface of DE and fast local search of gradient descent. As with all GO, global search capacity is gradually lost as the coefficient vectors converge together. Thus, re‐initialization is also incorporated into the hybrid algorithm to provide continuous global search capacity for non‐stationary environment. All the coefficient vectors except the best member are re‐initialized when the normalized mean Euclidean distance between each pair of vectors falls below a threshold value. Simulation results show that the proposed algorithm achieves better solution quality and convergence speed than classic DE and GO for stationary and non‐stationary environments. Copyright © 2013 John Wiley & Sons, Ltd.