bluuebunny/crossref_metadata_2025_split huggingface dataset:
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
Authors: Murphy James M. , Zhang Qingwei , Young Samuel N. , Reese Michael L. , Bailey Fiona P. , Eyers Patrick A. , Ungureanu Daniela , Hammaren Henrik , Silvennoinen Olli , Varghese Leila N. , Chen Kelan , Tripaydonis Anne , Jura Natalia , Fukuda Koichi , Qin Jun , Nimchuk Zachary , Mudgett Mary Beth , Elowe Sabine , Gee Christine L. , Liu Ling , Daly Roger J. , Manning Gerard , Babon Jeffrey J. , Lucet Isabelle S. 
Published: October 2013

Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl transfer, termed pseudokinases, have emerged as important signalling domains across all kingdoms of life. Although predicted to function principally as catalysis-independent protein-interaction modules, several pseudokinase domains have been attributed unexpected catalytic functions, often amid controversy. We established a thermal-shift assay as a benchmark technique to define the nucleotide-binding properties of kinase-like domains. Unlike in vitro kinase assays, this assay is insensitive to the presence of minor quantities of contaminating kinases that may otherwise lead to incorrect attribution of catalytic functions to pseudokinases. We demonstrated the utility of this method by classifying 31 diverse pseudokinase domains into four groups: devoid of detectable nucleotide or cation binding; cation-independent nucleotide binding; cation binding; and nucleotide binding enhanced by cations. Whereas nine pseudokinases bound ATP in a divalent cation-dependent manner, over half of those examined did not detectably bind nucleotides, illustrating that pseudokinase domains predominantly function as non-catalytic protein-interaction modules within signalling networks and that only a small subset is potentially catalytically active. We propose that henceforth the thermal-shift assay be adopted as the standard technique for establishing the nucleotide-binding and catalytic potential of kinase-like domains.
Measurement of optical coupling between adjacent bi-material microcantilevers
Authors: Canetta Carlo , Narayanaswamy Arvind 
Published: October 2013

Low thermal conductance bi-material microcantilevers are fabricated with a pad area near the free end to accommodate a focused laser spot. A pair of such cantilevers are proposed as a configuration for measuring thermal conductance of a nanostructure suspended between the two. We determine the resolution of such a device by measuring the stray conductance it would detect in the absence of any nanostructure. Stray conductance, primarily due to optical coupling, is measured for cantilevers with varying pad size and found to be as low as 0.05 nW K−1, with cantilevers with larger pad size yielding the smallest stray conductance.
Assessing the Relative Burden of Hospital-Acquired Infections in a Network of Community Hospitals
Authors: Lewis Sarah S. , Moehring Rebekah W. , Chen Luke F. , Sexton Daniel J. , Anderson Deverick J. 
Published: October 2013

Hospital-acquired infections (HAIs) occur commonly, cause significant harm to patients, and result in excess healthcare expenditures. The urinary tract is frequently cited as the most common site of HAI, but these estimates were extrapolated from National Nosocomial Infection Surveillance (NNIS) data from the 1990s. Updated information regarding the relative burden of specific types of HAIs would help governmental agencies and other stakeholders within the field of infection prevention to prioritize areas for research and innovation. The objective of our study was to assess the relative proportion of HAIs attributed to each of the following 5 types of infection in a network of community hospitals: catheter-associated urinary tract infection (CAUTI), surgical site infection (SSI), ventilator-associated pneumonia (VAP), central line–associated bloodstream infection (CLABSI), and Clostridium difficile infection (CDI).We performed a retrospective cohort study using prospectively collected HAI surveillance data from hospitals participating in the Duke Infection Control Outreach Network (DICON). DICON hospital epidemiologists and liaison infection preventionists work directly with local hospital infection preventionists to provide surveillance data validation, benchmarking, and infection prevention consultation services to participating hospitals.
Increased Risk of Intraoperative Awareness in Patients with a History of Awareness
Authors: Aranake Amrita , Gradwohl Stephen , Ben-Abdallah Arbi , Lin Nan , Shanks Amy , Helsten Daniel L. , Glick David B. , Jacobsohn Eric , Villafranca Alex J. , Evers Alex S. , Avidan Michael S. , Mashour George A. 
Published: October 2013

Abstract

Background:
Patients with a history of intraoperative awareness with explicit recall (AWR) are hypothesized to be at higher risk for AWR than the general surgical population. In this study, the authors assessed whether patients with a history of AWR (1) are actually at higher risk for AWR; (2) receive different anesthetic management; and (3) are relatively resistant to the hypnotic actions of volatile anesthetics.

Methods:
Patients with a history of AWR and matched controls from three randomized clinical trials investigating prevention of AWR were compared for relative risk of AWR. Anesthetic management was compared with the use of the Hotelling’s T2 statistic. A linear mixed model, including previously identified covariates, assessed the effects of a history of AWR on the relationship between end-tidal anesthetic concentration and bispectral index.

Results:
The incidence of AWR was 1.7% (4 of 241) in patients with a history of AWR and 0.3% (4 of 1,205) in control patients (relative risk = 5.0; 95% CI, 1.3–19.9). Anesthetic management did not differ between cohorts, but there was a significant effect of a history of AWR on the end-tidal anesthetic concentration versus bispectral index relationship.

Conclusions:
Surgical patients with a history of AWR are five times more likely to experience AWR than similar patients without a history of AWR. Further consideration should be given to modifying perioperative care and postoperative evaluation of patients with a history of AWR.
Dual Functions of Lactobacillus acidophilus NCFM as Protection Against Rotavirus Diarrhea
Authors: Liu Fangning , Wen Ke , Li Guohua , Yang Xingdong , Kocher Jacob , Bui Tammy , Jones Dorothy , Pelzer Kevin , Clark‐Deener Sherrie , Yuan Lijuan 
Published: October 2013

ABSTRACTObjective:The aim of the study was to examine the dose effects of Lactobacillus acidophilus (LA) NCFM strain on rotavirus‐specific antibody and B‐cell responses in gnotobiotic pigs vaccinated with an oral attenuated human rotavirus (AttHRV).Methods:Pigs were inoculated with AttHRV vaccine in conjunction with high‐dose LA (14 doses, total 2.2 × 109 colony‐forming units [CFU]), intermediate‐dose LA (MidLA) (9 doses, total 3.2 × 106 CFU), low‐dose LA (LoLA) (5 doses, total 2.1 × 106 CFU), or without LA feeding. Protection against rotavirus shedding and diarrhea was assessed upon challenge with a virulent HRV. Rotavirus‐specific immunoglobulin A (IgA) and IgG antibodies in serum and rotavirus‐specific IgA and IgG antibody‐secreting cells (ASCs) and memory B cells in ileum, spleen, and blood of the pigs were measured and compared among treatment groups.Results:The MidLA, but not high‐dose LA or LoLA, significantly reduced rotavirus diarrhea (MidLA‐only group) and significantly improved the protection conferred by AttHRV vaccine (MidLA + AttHRV group). Associated with the increased protection, MidLA significantly enhanced rotavirus‐specific antibody, ASCs, and memory B‐cell responses to AttHRV vaccine. High‐dose LA or LoLA did not enhance virus‐specific antibody and ASC responses, and hence did not improve the vaccine efficacy.Conclusions:These findings highlight the importance of dose selection and indicate that certain specific lactobacilli strains at the appropriate dose have the dual function of reducing rotavirus diarrhea and enhancing the immunogenicity and protective efficacy of rotavirus vaccines.
Asymmetric effect of market liquidity demand shocks on price shocks
Authors: Xu Xinzhe , Yang Chaojun , Chen Daolun , Chen Gongmeng 
Published: October 2013

Purpose
– With the launch of CSI 300 Index Futures trading on April 16, 2010, China's stock market presents a more diversified trend, such as arbitrage, trends strategy entering the market rapidly. Therefore, the liquidity demand also presents a higher frequency, and the change is more complex than the original situation. In recent years, many literatures are engaged in high-frequency trading (HFT) related research, and an important concern is the impact of HFT on market volatility and liquidity. Is it playing the role of stabilizing the market, or bringing more noise and turmoil? Based on this, the purpose of this study is trying to study what kind of impact the HFT have on market liquidity before and after the launch of the CSI 300 Index Futures.

Design/methodology/approach
– The paper uses the simultaneous equations model of price and net order flow proposed by Deuskar and Johnson and for the first time introduces an asymmetric identification through heteroskedasticity (ITH) method. The paper applies the method to the high-frequency data of CSI 300 Index and the Futures and classifies the buying and selling orders through volume clock. The price risks are decomposed into a component driven by the impact of liquidity demand shocks (flow-driven risks (FDRs)) and a component driven by external information (information-driven risks (IDRs)).

Findings
– The empirical results show that the flow-driven risk of CSI 300 Index Futures is about 20 percent. In addition, before the introduction of the Index Futures, there is no asymmetric effect between liquidity demand shocks and price shocks existing in either CSI 300 Index or CSI 300 Index Futures. While after the introduction of stock Index Futures, the asymmetric effect in the both two markets emerges. The impact of the buying net order flows on the price is less than the impact of the selling net order flows on CSI 300 Index, whereas the impact of the buying net order flows on the price is larger than the impact of the selling net order flows on CSI 300 Index Futures. The paper further analyzes the relationship between liquidity and FDR and gets the conclusion that the reasons for the deterioration of the liquidity level are caused by the impact of the external information shocks, rather than the liquidity demand shocks. And entries of HFTs like arbitrage traders and hedge traders play a positive role in improving the liquidity level in the market.

Originality/value
– The paper introduces an asymmetric ITH method for the first time and finds asymmetric effect of the net order flow on the return in both CSI 300 Index market and the corresponding Index Futures market.
Simulation to effect of monetary policy with constraint threshold
Authors: Ma Li , Yang Jiayi , Niu Yong 
Published: October 2013

Purpose
– Since monetary policy has great economic impacts, before the policy implementation, careful simulation combined with real economy movement condition can predict the policy implementation effect and reduce the cost of monetary policy implementation effectively. The paper aims to discuss these issues.

Design/methodology/approach
– This paper selects the large commercial banks in China as the research objects, takes commercial bank capital adequacy requirement as the threshold constraint on the traditional monetary policy transmission path, and simulates the implementation effects of policy combination by applying computer technology.

Findings
– It shows that the threshold effect of capital restriction policy will affect the transmission path of monetary policy, suppress the collective irrational behavior caused by the profit maximization behavior of commercial banks, and control the excessive fluctuation of macro economy.

Research limitations/implications
– If using capital adequacy constraints threshold function scientifically and appropriately, the paper can effectively eliminate the negative effect of short-term traditional monetary policy transmission mechanism, control the macroeconomic overall risk within a predetermined range, and realize the goal of monetary policy with low cost.

Originality/value
– Based on the theory of credit rationing from Stigliz and Weiss, combining threshold factors of capital restraint policy with the traditional monetary policy transmission path, this paper examines that the policy combination may lead to the implementation effect. The method of simulation used in this paper has not been found in other literatures, and the results have strong implications to set up a reasonable and scientific macro-prudential banking regulation framework.
Can third party's collateral arrangements tackle the financing problem of small-medium enterprises?
Authors: Hong Zheng , Zhou YiHai 
Published: October 2013

Purpose
– Faced with the financing problem of small-medium enterprises (SMEs), China has attempted to establish as many as third party's collateral institutions. The paper aims to study the design of collateral arrangements including collateral fee rates, risk sharing, collateral capital requirements, types of collateral institutions and recollateral institution, etc.

Design/methodology/approach
– The paper extends the model of Holmstrom and Tirole to develop the analytic framework of the theory of financing collateral. From the perspective of contract design, the paper establishes a moral hazard model focusing on the minimum capital requirement of the borrower under the condition of risk neutral and limited liability, while considering the structure of lender-collateral institution-borrower.

Findings
– According to the research, only under certain conditions can third party's collateral arrangements tackle the financing problems of SMEs. Diversification, anti-collateral and linked-transactions are three means to improve financing conditions, but the most important way is efficient monitoring by collateral institutions, especially when it has relative advantage over the lender. In order to improve financing conditions of SMEs, China should rely more on efficient monitoring by banks not on excess development of collateral institutions, meanwhile relax rigid collateral supervision policies. Collateral institutions should be industry-specific, association or transaction-related type.

Originality/value
– First, from the perspective of contract design, the paper analyzes the comprehensive institutional arrangements of third party's collateral considering mutual relationships of component elements and develops the analytic framework of the theory of third party's collateral, especially points out necessary conditions of its efficient arrangements. Second, the paper studies various efficient financing mechanisms under the institutional arrangements of third party's collateral and focusing on the role of monitoring and monitors, and the paper also has important policy implications, i.e. the paper should develop specific collateral institutions and promote monitoring role of credit institutions.
Interdisciplinary professional education
Authors: Nandan Monica , London Manuel 
Published: October 2013

Purpose– The purpose of this paper is to provide a rationale for developing interprofessional competencies among graduates from professional and graduate programs, so that they are well prepared to participate in local, national and global social change strategies.Design/methodology/approach– After reviewing the literature on strategic social change initiatives the authors briefly describe two such initiatives: corporate social responsibility initiatives and social entrepreneurial ventures. After reviewing the interprofessional literature from various disciplines and professions, the authors categorized them into “competencies,” “rationale,” “conceptual framework,” “principles” and “challenges.” An examination of exemplar pedagogy from this body of literature suggests ways to prepare students to lead and actively participate in innovative, collaborative social change initiatives.Findings– Interdisciplinary competencies include teamwork, communication, contextual understanding, negotiation, critical thinking, leadership, openness and adaptability. Interprofessional educational models are difficult to implement, however, ethical responsibility of educators to prepare students for complex realities trumps the challenges.Practical implications– Interprofessional educational experiences can enable students to engage in generative and transformational learning which can later facilitate in creation of innovative solutions for society's recalcitrant physical, social and environmental issues.Originality/value– Based on the system's perspective, the paper provides guidelines and strategies for implementing interprofessional pedagogical initiative.
Risk factors for suicide among rural men: are farmers more socially isolated?
Authors: McPhedran Samara , De Leo Diego 
Published: October 2013

Purpose– International evidence demonstrates elevated suicide rates among farming occupations, relative to other occupations. A psychosocial factor commonly argued to contribute to farmer suicide is social isolation and lack of social support, which in turn may indicate a need for policies and programs to support farmers' social participation and connectedness with others. However, there has been very little empirical investigation of perceived levels of social connectedness and social participation among farmers. The paper aims to discuss these issues.Design/methodology/approach– This study used a cross-section of a nationally representative dataset, the Household, Income, and Labour Dynamics in Australia survey. This enabled quantification of Australian farmers' self-reported levels of social connectedness and social participation, relative to rural adult males in other occupations.Findings– Levels of perceived social support and social participation among farmers were approximately equivalent to social support and social participation among rural men in other occupations.Research limitations/implications– Possible mediating variables, such as influences of social support on mental health, were not examined in this study. However, these findings nonetheless suggest the assumption that social isolation is higher among farmers requires careful consideration.Originality/value– This is the first study that quantifies social support and social participation among farmers, using a comparative approach.
Are more equal societies the most cohesive?
Authors: Sage Daniel 
Published: October 2013

Purpose
– In recent decades, research across the social sciences has linked higher income inequality to poorer health and social outcomes in advanced market democracies. According to general theories, this relationship is mediated by social cohesion; an absence of which is said to be the cause behind such poor outcomes. This article aims to examine the first step in this theory by exploring whether there is an empirical relationship between income inequality and social cohesion.

Design/methodology/approach
– To achieve this, social cohesion is operationalized as 18 variables across six unique dimensions of social cohesion. Subsequently, the relationship between each variable and inequality is tested in a range of statistical models that include two measures of income inequality, numerous control variables and a range of different country samples.

Findings
– The relationship between inequality and social cohesion is found to be problematic, with significant associations for some dimensions but not for others. Further, the relationship between social cohesion and inequality is dependent on the measure of inequality used, whether other variables are controlled for and the number of countries in the sample. To explain this paradox, a distinction is made between “horizontal” and “vertical” social relations.

Originality/value
– This article argues that research into the health and social effects of income inequality has thus far largely failed to address the causal mechanisms by which negative outcomes are purportedly produced. By empirically examining the links between inequality and one of these hypothesized mechanisms, social cohesion, it is shown that there are relationships between inequality and some dimensions of social cohesion, but not between others. This suggests that the income inequality-social cohesion hypothesis is more complex than has hitherto been implied.
Ethno-cultural clusters and informal entrepreneurship in Russia
Authors: Karnaukhova Oxana 
Published: October 2013

Purpose
– This article aims to explore informal entrepreneurial activities in ethno-cultural clusters in the Russian South. It evaluates the agglomeration economy efforts of ethno-cultural communities and the formation of a new operations of the informal sector. The transition of the ethnic project “Obukhovsky Choir” from an informal to a formal enterprise is considered as unfinished. The emphasis is pointed at the barriers affecting the process and extra-economic factors influencing entrepreneurship activities in ethno-cultural clusters in Russia.

Design/methodology/approach
– For investigation of the informal entrepreneurship in the Southern Russian agglomeration, in-depth interviews method has been used. The paper researched concept of entrepreneurship and cultural entrepreneurship through the interviews, trying to distinguish the core factors influencing activities of Obukhovsky Choir. These questions concern motivation to enter entrepreneurship activity, regional and local policies affecting the overall situation, core values (ideology) of these types of activity, the role of institutional and other contexts, spatial distribution and social capital influence.

Findings
– The case of the Rostov agglomeration demonstrates the delayed development of ethno-cultural clusters and attempts to closure activities of communities into local political space. Rostov agglomeration has not stepped through the threshold and involved ethno-cultural communities in the formation of the “common good” conception. While Rostov agglomeration is still attractive for labour migration and migrants' entrepreneurial initiatives, local government does not support such intervention into the stable regional market. These steps delay the development of ethno-cultural clusters and contradict communication between ethnic communities, autochthonic population and local administration.

Originality/value
– The case chosen for analysis is Cossack music entrepreneurial space as a salient sample of ethno-cultural cluster with powerful economic potential. It could be used for further consideration of ethno-cultural cluster as a source for socio-economic modernization of Russian multicultural agglomeration where established ethnic communities' communicative style strategically provides support or opposition to the local administration initiatives.
Social protest: the Israeli case
Authors: Shuv-Ami Avichai 
Published: October 2013

Purpose
– The current study attempts to determine to what extent, if any, the protests of summer of 2011 affected public attitudes and behavior in Israel. More specifically, the objective of the current study was to examine by means of a survey, Israeli public attitudes toward: the social protest; the enterprises that were the focus of the protest; and the government and the state of Israel.

Design/methodology/approach
– The findings presented below are based on a survey that was conducted among 1,019 respondents during the second week of March 2012 via an internet panel. The sample represents the Hebrew-speaking population of Israel, with a maximum sampling error of +3.2 percent.

Findings
– The findings of the current study show that the Israeli public was united behind various demands of the protesters: to control the prices of basic products and services; to decrease the price of small apartments for young families; to reduce the income gap between the poor and the rich; and to increase the social services provided by the government.

Originality/value
– The first academic case study on the Israeli social protest.