bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appendectomy and the clinical course of ulcerative colitis: A retrospective cohort study and a nested case–control study from Korea
Authors: Lee Ho‐Su , Park Sang Hyoung , Yang Suk‐Kyun , Kim Seon‐Ok , Soh Jae Seung , Lee Seohyun , Bae Jung Ho , Lee Hyo Jeong , Yang Dong‐Hoon , Kim Kyung Jo , Ye Byong Duk , Byeon Jeong‐Sik , Myung Seung‐Jae , Kim Jin‐Ho 
Published: August 2014

AbstractBackground and AimAppendectomy protects against the development of ulcerative colitis (UC). However, the relationship between appendectomy and the clinical course of UC is complex, and could be impacted by a number of variables. The aim of this study was to compare the clinical course of UC between appendectomized patients and nonappendectomized patients in Korea.MethodsData on 2648 UC patients were retrieved from the Inflammatory Bowel Disease registry at Asan Medical Center. This retrospective cohort study compared the clinical course of UC in 68 patients who received an appendectomy before their UC diagnosis and 2544 patients who did not receive this procedure. A nested case–control study was also conducted to compare the disease course before and after appendectomy in 36 patients who received this surgery after UC diagnosis. To control for potential confounders, 144 matched controls were retrieved from among 2544 nonappendectomized patientsResultsIn the retrospective cohort study, an appendectomy before UC diagnosis demonstrated no influence on disease extent at diagnosis, rates of medication use, proximal disease extension, or colectomy. The 10‐ and 20‐year probabilities of receiving a colectomy were 12.7% and 20.6%, respectively, in appendectomized patients, in comparison with 8.9% and 16.4%, respectively, in nonappendectomized patients (P = 0.81). According to the nested case–control study, an appendectomy after UC diagnosis did not change the subsequent disease course in terms of medication use, proximal disease extension, or hospital admission rate. The adjusted ratio of hospital admissions after appendectomy versus before appendectomy was 1.01 (95% confidence interval = 0.46–2.23; P = 0.97).ConclusionsAppendectomies performed before or after UC diagnosis do not affect its clinical course in the Korean population.
TLR4, TLR9, and NLRP3 in biliary epithelial cells of primary sclerosing cholangitis: Relationship with clinical characteristics
Authors: Matsushita Hiroshi , Miyake Yasuhiro , Takaki Akinobu , Yasunaka Tetsuya , Koike Kazuko , Ikeda Fusao , Shiraha Hidenori , Nouso Kazuhiro , Yamamoto Kazuhide 
Published: August 2014

AbstractBackground and AimInappropriate innate immune responses have been suggested to contribute to the pathogenesis of primary sclerosing cholangitis (PSC). We evaluated the associations of expressions of toll‐like receptor (TLR) 4, TLR9, and nucleotide‐binding oligomerization domain‐containing protein (NOD)‐like receptor family pyrin domain containing 3 (NLRP3) in the biliary epithelial cells (BECs) with clinical features of PSC patients.MethodsWe retrospectively evaluated the expressions of TLR4, TLR9, and NLRP3 in the intrahepatic BECs by immunohistochemical staining in 21 PSC patients and 10 normal controls. In PSC, 17 patients underwent liver biopsy, and, in the other four patients, liver specimens were obtained at the time of liver transplantation.ResultsTLR9 expressions in BECs were higher in PSC patients than in normal controls. TLR9 expressions were correlated with Ludwig fibrosis scores in PSC patients. TLR4 and NLRP3 expressions were similar between PSC patients and normal controls. Seventeen PSC patients undergoing liver biopsy were followed up during a median period of 55.7 months. Four reached to liver transplantation and four developed cholangiocarcinoma. Patients developing cholangiocarcinoma showed lower NLRP3 expressions than the others. Patients reaching to liver transplantation showed higher TLR9 expressions. Expression levels of TLR9 and NLRP3 were not correlated with liver biochemical tests and Mayo risk scores.ConclusionsIn PSC, excessive immune responses through TLR9 signaling may be associated with the disease progression. Insufficient immune response through NLRP3 signaling may be associated with the development of cholangiocarcinoma. Evaluation of TLR9 and NLRP3 expressions in BECs may be useful for predicting the prognosis as an auxiliary marker.
No increased risk of hepatocellular carcinoma in cirrhosis due to Wilson disease during long‐term follow‐up
Authors: van Meer Suzanne , de Man Robert A , van den Berg Aad P , Houwen Roderick H J , Linn Francisca H H , van Oijen Martijn G H , Siersema Peter D , van Erpecum Karel J 
Published: August 2014

AbstractBackground and AimsData on risk of hepatocellular carcinoma (HCC) in patients with Wilson disease are scarce. We determine HCC risk in a well‐defined cohort of Wilson patients.MethodsAll patients with a confirmed diagnosis of Wilson disease (Leipzig score ≥ 4) in three Dutch university referral hospitals were included in this retrospective cohort study. End of follow‐up was defined as date of diagnosis of HCC, liver transplantation, death, or last available hospital visit. Also, a meta‐analysis was performed to determine incidence and mortality rate of HCC in Wilson disease based on all published cohorts.ResultsIn total, 130 patients with Wilson disease were followed during a median follow‐up of 15 years (range 0.1–51.2). At baseline, cirrhosis was present in 74 patients (57% of total: 64% compensated, and 36% decompensated). At end of follow‐up, liver disease severity was improved, stable or deteriorated in 20%, 46%, and 24% of all cases (10% unknown), respectively. Two patients developed HCC (one despite excellent decoppering after 50 years follow‐up, the other with newly diagnosed Wilson disease). Estimated annual HCC risk for all patients was 0.09% (95% confidence interval [CI]: 0.01–0.28). Subgroup analysis in cirrhotic patients revealed an annual HCC risk of 0.14% (95% CI: 0.02–0.46). The meta‐analysis showed an annual HCC risk of 0.04% (95% CI: 0.01–0.10) and HCC mortality rate of 2.6/10 000 person‐years (95% CI: 0.7–7.0).ConclusionsEven in case of cirrhosis, HCC risk is low in Wilson disease. Our data do not support regular HCC surveillance in Wilson disease.
“The Pure Hard Slog That Nursing Is . . .”: A Qualitative Analysis of Nursing Work
Authors: Bogossian Fiona , Winters‐Chang Peta , Tuckett Anthony 
Published: August 2014

AbstractPurposeTo explore nurses' perceptions of the nature of nursing work as a factor that contributes to attrition from the profession.DesignA nonpurposive sample of nurses from the Nurses and Midwives e‐cohort Study in Australia, New Zealand, and the United Kingdom provided electronic responses about reasons for leaving the profession. Data were then subjected to qualitative content analysis.FindingsNurses at the “coal face,” that is, those who actually do the work of nursing, in real working conditions, express dissatisfaction in relation to hygiene factors relating to the nature of nursing work and attribute these to nurses leaving the profession: workload, shift work, violence, and financial remuneration.ConclusionsNurses’ satisfaction with work and motivation to work are being sorely tested. There is manifest tension between the core concepts of nursing—compassion and care—and a system of work that actively precludes nurses from being able to exhibit these virtues and fails to reward them. Workload, shift work, violence, and financial remuneration are drivers of attrition and need to be addressed.Clinical RelevanceImplications from this study are fourfold: determination of nursing workload, mitigating the impact of shift work, providing safe work environments, and adequate financial remuneration.
Surgical resolution of obstructive dyspareunia after traumatic pelvic injury
Authors: Lee Yoon Kyung , Kim Su Mi , Jeung In Cheul , Park Eun Kyung , Kim Weon Yoo , Lee Yong Seok 
Published: August 2014

AbstractAs more of the patients with traumatic pelvic injuries survive, they desire an optimal quality of life, including normal sexual function, even after the most severe injuries. We present the case of a 31‐year‐old woman who had dyspareunia due to impaired vaginal penetration after severe pelvic injury. After excision of a disunited fragment of pelvic bone and an adhesion band at the vaginal wall, dyspareunia was considerably resolved and the patient resumed sexual function. In cases of severe pelvic injury, physicians used to be satisfied with the patient's survival alone, and tended to regard sexual dysfunction as a trivial outcome. However, restoration of sexual function is an important part of management of these patients. In selected cases, obstructive dyspareunia resulting from traumatic pelvic injury can be managed by planned surgical intervention.
Intrapartum and neonatal outcome of screening non‐stress test (NST) compared with no screening NST in healthy women at 40–40 (+6) weeks of gestation
Authors: Kiettisanpipop Patcharin , Phupong Vorapong 
Published: August 2014

AbstractAimThe aim of this study was to compare the intrapartum and neonatal outcome between screening non‐stress test (NST) and no screening NST groups in healthy pregnant women at a gestational age of 40–40+6 weeks.MethodsHealthy pregnant women, with a gestational age of 40–40+6 weeks who had received antenatal care and delivered at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, between 1 July 2011 and 31 March 2013, were included in the study. The treatment group consisted of women who had had screening NST while no NST screening had been performed in the control group. The primary outcome was intrapartum and neonatal outcome, which included stillbirth, the incidence of non‐reassuring fetal heart, neonatal morbidity (meconium aspiration, respiratory distress, neonatal asphyxia) and neonatal mortality. Secondary outcome was the cost‐effectiveness of the NST screening.ResultsA total of 460 healthy pregnant women with a gestational age of 40–40+6 weeks were included in the study. There were 228 cases in the NST screening group and 232 cases in the no NST screening group. There was no significant difference in the incidence of stillbirth, non‐reassuring fetal heart, neonatal morbidity (meconium aspiration, respiratory distress, neonatal asphyxia) and neonatal mortality. The cost of NST plus neonatal care was higher in the NST screening group than the no NST screening group.ConclusionRoutine performing NST at the gestational age of 40–40+6 weeks has no benefit in intrapartum and neonatal outcome.
Three‐year questionnaire survey on human papillomavirus vaccination targeting new female college students
Authors: Sukegawa Akiko , Ohshige Kenji , Arai Suzuko , Sakanashi Kaoru , Usui Masami , Hirahara Fumiki , Miyagi Etsuko 
Published: August 2014

AbstractAimA questionnaire survey was conducted at fixed points to describe changes over a 3‐year period in the human papillomavirus (HPV) vaccination uptake rate among young women. Several factors obtained from the questionnaire were investigated in relation to HPV vaccination.MethodsThe study was conducted at two universities in Yokohama City, Japan. Newly enrolled female students of the universities were recruited to participate in this study in 2011, 2012 and 2013. The study participants were asked about their HPV vaccination status. They were also questioned about factors that potentially influenced HPV vaccination, such as current age, place of residence during high school, and knowledge related to cervical cancer and HPV vaccination.ResultsThe proportion of vaccinated participants dramatically increased in 2013 (48.7%) in comparison to 2011 (5.4%) and 2012 (13.5%). Three factors were positively related to HPV vaccination: being 18 years old in 2013, which means that they were eligible for a financial support program (P < 0.001); living in the study city, in which HPV vaccination was well conducted (P < 0.001); and proper knowledge of cervical cancer and HPV vaccination (P < 0.001).ConclusionThe HPV vaccination uptake rate in 2013 dramatically increased from that in 2011. Official financial support and publicity work were likely to have had an effect on the HPV vaccination uptake rate.
The emerging role of microRNAs in cardiovascular disease
Authors: Maegdefessel L. 
Published: August 2014

AbstractCardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocardial infarction, and diabetes mellitus and arterial hypertension. Progress in molecular medicine and biology has unravelled a complex epigenetic and post‐transcriptional gene‐regulating machinery in humans which may limit disease development. An increasing number of attractive molecular strategies, which use the potential of modulating noncoding RNAs, have surfaced over the last decade. Currently, the most extensively studied gene‐regulating RNA subspecies are microRNAs, which have been shown to adjust the translational output of coding transcripts by enforcing their degradation and inhibiting their translation into protein. Key findings indicate that microRNAs act as crucial regulators in the majority of human pathologies. Thus, recent research has focused on detecting and modulating microRNAs for therapeutic and biomarker purposes. This review focuses on main and repeated discoveries regarding the role and the therapeutic and biomarker feasibility of microRNAs during cardiovascular disease development and exacerbation.
Harsh Evaluations of Entrepreneurs Who Fail: The Role of Sexual Orientation, Use of Environmentally Friendly Technologies, and Observers' Perspective Taking
Authors: Shepherd Dean A. , Patzelt Holger 
Published: August 2014

AbstractAlthough there is a pervasive anti‐failure bias in society, we investigate why some entrepreneurs who fail are evaluated more harshly than others. Building on attribution theory and the literatures on prejudice, pro‐social intentions, and perspective taking, we offer an evaluation model of entrepreneurial failure and test this model on 6,784 assessments made by 212 observers. We find that variance in the harshness of failure evaluations depends on both the attributes of the entrepreneur and the attributes of the observer, and the interaction between the two. Specifically, entrepreneurs who are homosexual are evaluated more harshly by some observers and entrepreneurs who use environmentally friendly technology are evaluated less harshly. Moreover, observers high in perspective taking are more ‘lenient’ in their failure evaluations of those who use environmentally friendly technology than those low in perspective taking.
Involvement of autophagy in melatonin‐induced cytotoxicity in glioma‐initiating cells
Authors: Martín Vanesa , Sanchez‐Sanchez Ana María , Puente‐Moncada Noelia , Gomez‐Lobo Marina , Alvarez‐Vega Marco Antonio , Antolín Isaac , Rodriguez Carmen 
Published: August 2014

AbstractGlioblastoma‐initiating cells (GICs) represent a stem cell‐like subpopulation within malignant glioblastomas responsible for tumor development, progression, therapeutic resistance, and tumor relapse. Thus, eradication of this subpopulation is essential to achieve stable, long‐lasting remission. We have previously reported that melatonin decreases cell proliferation of glioblastoma cells both in vitro and in vivo and synergistically increases effectiveness of drugs in glioblastoma cells and also in GICs. In this study, we evaluated the effect of the indolamine alone in GICs and found that melatonin treatment reduces GICs proliferation and induces a decrease in self‐renewal and clonogenic ability accompanied by a reduction in the expression of stem cell markers. Moreover, our results also indicate that melatonin treatment, by modulating stem cell properties, induces cell death with ultrastructural features of autophagy. Thus, data reported here reinforce the therapeutic potential of melatonin as a treatment of malignant glioblastoma both by inhibiting tumor bulk proliferation or killing GICs, and simultaneously enhancing the effect of chemotherapy.
IASSIDD Academy on Education, Teaching, and Research: The Genesis and Evolution of an Idea
Authors: Brown Roy I. 
Published: August 2014

AbstractThe author provides an overview of the development of the IASSIDD Academy from its inception to December 2013. The commentary represents the personal reflections of the founding director of the Academy in terms of its mission and its history of carrying out activities around the world. Outlined are some of the challenges and successes, as well as some of the future needs in terms of the Academy's relevance both inside and beyond IASSIDD. The author notes that with the formation of a board of directors, the development of IASSIDD Academy bylaws along with mission statements, and the design and work with various agencies and communities around the world, the Academy has now moved into a period of consolidation and renewed progress.
Facilitating and Impeding Factors for Knowledge Translation in Intellectual and Developmental Disabilities: Results from a Consultation Workshop in Iran
Authors: Shooshtari Shahin , Samadi Sayyed Ali , Zarei Khatoon , Naghipur Saba , Martin Toby , Lee May 
Published: August 2014

AbstractThe authors report on the outcome of a consultation workshop held in Iran, which focused on knowledge translation (KT) and intellectual and developmental disability (IDD). The goal was to learn more about the contextual factors that facilitate and impede KT in applications related to IDD in Iran. Forty‐six stakeholders participated, representing the perspectives of policy‐makers, administrators, parents, practitioners, and researchers. The authors introduced a conceptual framework for KT and assessed KT capacity using a validated tool. They facilitated discussions among stakeholder groups with respect to contextual facilitating and impeding factors, and suggested ways to improve IDD‐related KT activities in Iran. The authors found that all of the stakeholder groups highly valued research, but there were statistically significant differences among the participating stakeholder groups in acquiring, accessing, adapting, and applying research information to their practice. A number of factors, including the existing connections between parents and practitioners, could potentially facilitate the development of collaborative KT strategies. A lack of time, incentives, and resources were reported by all stakeholder groups as impeding factors for KT in IDD. The authors believe the researchers in Iran need to work closer with stakeholder groups to develop KT strategies with respect to IDD and thus achieve more effective dissemination of research findings that affect policy and practice.
The development and effectiveness of a health information website designed to improve parents' self‐efficacy in managing risk for obesity in preschoolers
Authors: Davies Marilyn A. , Terhorst Lauren , Nakonechny Amanda J. , Skukla Nimisha , El Saadawi Gilan 
Published: August 2014

AbstractPurposeTo evaluate the effects of web‐based information on parental self‐efficacy in managing obesity risk in preschoolers.Design and MethodsThe project included a literature review and the development and field testing of an information website that presented information on how to manage nine obesity risk factors for childhood obesity.ResultsParents stated that they had no problems using the website, and 69% reported improved self‐efficacy on at least two risk factors.Practice ImplicationsMany parents access the Internet to obtain health information. A website that offers practical information on managing childhood obesity risk factors is a valuable resource for obesity prevention efforts.
Relationship between energy expenditure and stress behaviors of preterm infants in the neonatal intensive care unit
Authors: Lin Hung‐Chih , Huang Li‐Chi , Li Tsai‐Chung , Chen Chau‐Huei , Bachman Jean , Peng Niang‐Huei 
Published: August 2014

AbstractPurposeThis research evaluated the relationship between behaviors and energy expenditure in preterm infants receiving nursing interventions.Design and MethodsThis study was an explorative secondary data analysis from a previous study. The current study investigated energy expenditure calculated using heart rate‐based energy expenditure‐estimate across 500 repeated measures for 37 infants.ResultsResearch results indicate that preterm infants expend more energy when they show the following seven behaviors: grimace, sucking, diffusion squirm, fist, gape face, salute, and sneezing.Practice ImplicationsThe interventions for preterm infants should be flexible, according to the infant's stress behaviors and conditions of energy expenditure.
Sleep and moral awareness
Authors: Barnes Christopher M. , Gunia Brian C. , Wagner David T. 
Published: August 2014

SummaryThe implications of sleep for morality are only starting to be explored. Extending the ethics literature, we contend that because bringing morality to conscious attention requires effort, a lack of sleep leads to low moral awareness. We test this prediction with three studies. A laboratory study with a manipulation of sleep across 90 participants judging a scenario for moral content indicates that a lack of sleep leads to low moral awareness. An archival study of Google Trends data across 6 years highlights a national dip in Web searches for moral topics (but not other topics) on the Monday after the Spring time change, which tends to deprive people of sleep. Finally, a diary study of 127 participants indicates that (within participants) nights with a lack of sleep are associated with low moral awareness the next day. Together, these three studies suggest that a lack of sleep leaves people less morally aware, with important implications for the recognition of morality in others.
Telomeric 1p36.3 deletion and Ki‐67 expression in B‐Non‐Hodgkin's Lymphoma patients associated with chronic hepatitis C virus infection
Authors: Mosad E. , Said Abd El‐Rahman Allam M. , Moustafa H. M. , Mohammed A. Eliaw , El kebeer A. M. , Abdel‐Moneim S. S. 
Published: August 2014

SummaryThe hepatitis C virus (HCV) core protein is able to accumulate genetic p53 mutations and may be considered co‐oncogenic. This study investigates 1p36.3 telomere deletion in B‐non‐Hodgkin's lymphoma (NHL) patients with chronic HCV infection using fluorescence in situ hybridization (FISH) in relation to survival to assess Ki‐67 antigen expression. A study group and a control group of 100 patients with B‐NHL (50 HCV positive and 50 HCV negative) and 60 control bone marrow biopsies were subjected to FISH for the detection of 1P36.3 deletion and to immunohistochemical staining with Ki‐67 antigens. 1p36.3 deletion by FISH was detected in 40% of the study group, and Ki‐67 was expressed in approximately 74% of patients. A significant difference was found between positive and negative HCV patients in their overall survival, the qualitative expression of Ki‐67 and the quantitative detection of 1p36.3 deletion by FISH. The overall survival was shorter with the presence of an 1p36 deletion by FISH and HCV positive. We concluded that the coexistence of Ki‐67 positivity, HCV positivity and 1p36.3 deletion may contribute to infection‐related cancers at the 1p36.3 locus.