bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promise of personalized omics to precision medicine
Authors: Chen Rui , Snyder Michael 
Published: November 2012

AbstractThe rapid development of high‐throughput technologies and computational frameworks enables the examination of biological systems in unprecedented detail. The ability to study biological phenomena at omics levels in turn is expected to lead to significant advances in personalized and precision medicine. Patients can be treated according to their own molecular characteristics. Individual omes as well as the integrated profiles of multiple omes, such as the genome, the epigenome, the transcriptome, the proteome, the metabolome, the antibodyome, and other omics information are expected to be valuable for health monitoring, preventative measures, and precision medicine. Moreover, omics technologies have the potential to transform medicine from traditional symptom‐oriented diagnosis and treatment of diseases toward disease prevention and early diagnostics. We discuss here the advances and challenges in systems biology‐powered personalized medicine at its current stage, as well as a prospective view of future personalized health care at the end of this review. WIREs Syst Biol Med 2013, 5:73–82. doi: 10.1002/wsbm.1198This article is categorized under:

Analytical and Computational Methods > Analytical Methods
Laboratory Methods and Technologies > Genetic/Genomic Methods
Translational, Genomic, and Systems Medicine > Translational Medicine
Persistent massive attractors of smooth maps
Authors: VOLK D. 
Published: November 2012

AbstractFor a smooth manifold of any dimension greater than one, we present an open set of smooth endomorphisms such that any of them has a transitive attractor with a non-empty interior. These maps are m-fold non-branched coverings, m≥3. The construction applies to any manifold of the form S1×M, where S1 is the standard circle and Mis an arbitrary manifold.
Effect of sowing date and variety on yield and weed populations in a lentil–barley mixture
Authors: WANG L. , GRUBER S. , CLAUPEIN W. 
Published: November 2012

SUMMARYThe present study examined variation in sowing date on lentils (Lens culinaris) in a standard lentil–barley (Hordeum vulgare) mixed cropping system in the temperate climate of central Europe to determine the effect on crop yield and weed control. A 2-year (2009/10) field experiment was carried out at the organic research station Kleinhohenheim (KH) and at the conventional research station Oberer Lindenhof (OLI) of the University Hohenheim, southwest Germany. The crop was sown at three dates in the period from March to May. Grain yield was significantly higher at the earliest sowing both for lentils (3·0 t/ha at KH, 2·4 t/ha at OLI) and barley (1·2 t/ha at KH, 2·6 t/ha at OLI). Weed biomass at KH increased significantly with delayed sowing and was independent of lentil genotype, whereas sowing date had no significant effect on overall weed biomass production at OLI. Unlike weed biomass, weed density generally decreased significantly with delayed sowing at OLI. The results indicate that early sowing can increase the yield of lentils, and can be used as an indirect method of weed control in some organic farming systems.
Effective results for unit equations over finitely generated integral domains
Authors: EVERTSE JAN–HENDRIK , GYŐRY KÁLMÁN 
Published: November 2012

AbstractLetA⊃ ℤ be an integral domain which is finitely generated over ℤ and leta,b,cbe non-zero elements ofA. Extending earlier work of Siegel, Mahler and Parry, in 1960 Lang proved that the equation (*)aϵ +bη =cin ϵ, η ∈A* has only finitely many solutions. Using Baker's theory of logarithmic forms, Győry proved, in 1979, that the solutions of (*) can be determined effectively ifAis contained in an algebraic number field. In this paper we prove, in a quantitative form, an effective finiteness result for equations (*) over an arbitrary integral domainAof characteristic 0 which is finitely generated over ℤ. Our main tools are already existing effective finiteness results for (*) over number fields and function fields, an effective specialization argument developed by Győry in the 1980's, effective results of Hermann (1926) and Seidenberg (1974) on linear equations over polynomial rings over fields, and similar such results by Aschenbrenner, from 2004, on linear equations over polynomial rings over ℤ. We prove also an effective result for the exponential equationaγ1v1···γsvs+bγ1w1··· γsws=cin integersv1,…,ws, wherea,b,cand γ1,…,γsare non-zero elements ofA.
Risk ofStaphylococcus aureuscarriage in childcare employees
Authors: MORITZ E. D. , SMITH T. C. 
Published: November 2012

SUMMARYAsymptomatic carriage ofStaphylococcus aureusis an important risk factor for developing infection, as well as a key contributor to transmission. Despite the fact that childcare workers are at known risk for infections, little research has focused on bacterial carriage in this occupational group. We conducted a cross-sectional study comparing the prevalence ofS. aureusin 110 childcare employees with the prevalence in 111 unexposed participants. Questionnaire data was collected for employees, unexposed adults, and children. Multivariate analysis allowed for adjustment for confounders. Data on work-related exposures are presented as well. The prevalence ofS. aureusin employees, unexposed adults, children, and on surfaces was 35·2%, 33·6%, 19·8%, and 9·8%, respectively. Washing children's hands upon their arrival at childcare facilities may decrease the risk ofS. aureuscarriage in employees (odds ratio 0·17, 95% confidence interval 0·095–0·32,P < 0·0001).
Grammatical relation probability: How usage patterns shape analogy
Authors: Brown Esther L. , Rivas Javier 
Published: November 2012

AbstractIt has been argued speakers' knowledge of the probabilities of certain phones, words, and syntactic structures affects language production (Bell, Brenier, Gregory, Girand, & Jurafsky, 2009; Tily, Gahl, Arnon, Snider, Kothari, & Bresnan, 2009). This study provides evidence for effects of grammatical relation probabilities by identifying significant effects on verb morphology in the Spanish presentative [haber‘there (be)’+ NP] construction stemming from nouns with varying proportion of use in subject function. In addition to this novel type of probability (grammatical relation), we present calculations that are not context-dependent but cumulative, reflecting speakers' overall experience with these nouns in the grammar. We conduct variationist analyses on corpora of spoken Puerto Rican Spanish. Our results reveal that nouns with a high probability of subject function promote the analogical leveling ofhaberby increasing the likelihood of reanalysis of the object as subject of the construction. We interpret these results as suggesting speakers possess lexicalized knowledge of grammatical relation usage patterns.
Nutrition and the HIV-associated lipodystrophy syndrome
Authors: Loonam Cathríona Rosemary , Mullen Anne 
Published: November 2012

HIV-associated lipodystrophy syndrome (HALS), comprising metabolic and morphological alterations, is a known side effect of highly active antiretroviral therapy (HAART). Evidence for the role of nutrition in the management of the systemic parameters of HALS is currently limited. In the present paper we review the current knowledge base surrounding HALS, focusing particularly on the role of nutrition in mitigating the systemic parameters of the syndrome. Reported prevalence of HALS was found to vary from 9 to 83 % due to lack of a standardised definition, as well as variations in assessment methods and in the study population used. HALS is associated with both morphological (lipoatrophy, lipohypertrophy) and metabolic (dyslipidaemia, glucose intolerance, diabetes, hypertension, endothelial dysfunction and atherosclerosis) alterations, which may occur singly or in combination, and are associated with an increased risk of CVD. HAART-induced adipocyte inflammation, oxidative stress and macrophage infiltration, as well as altered adipocyte function and mitochondrial toxicity, have been shown to be central to the development of HALS. The adipocyte, therefore, represents a plausible target for treatment. Pharmacological and surgical treatment interventions have shown effect. However, their use is associated with numerous adverse effects and complications. Targeted lifestyle interventions may provide a useful alternative for managing HALS owing to their safety and tolerability. A Mediterranean-style diet has been found to be effective in improving the systemic parameters of HALS. Furthermore, the effects ofn-3 PUFA supplementation are encouraging and future randomised controlled trials investigating the beneficial effects ofn-3 PUFA in HALS are justified.
Design and characterization of 50 kW solid-state RF amplifier
Authors: Jain Akhilesh , Hannurkar P. R. , Sharma D. K. , Gupta A. K. , Tiwari A. K. , Lad M. , Kumar R. , Gupta P. D. , Pathak S. K. 
Published: November 2012

Radio frequency (RF) and microwave amplifier research has been largely focused on solid-state technology in recent years. This paper presents design and performance characterization of a 50-kW modular solid-state amplifier, operating at 505.8 MHz. It includes architecture selection and design procedures based on circuit and EM simulations for its building blocks like solid-state amplifier modules, combiners, dividers, and directional couplers. Key performance objectives such as efficiency, return loss, and amplitude/phase imbalance are discussed for this amplifier for real-time operation. This amplifier is serving as the state-of-the-art RF source in Indus-2 synchrotron radiation source. Characterization on component level as well as system level of this amplifier serves useful data for RF designers working in communication and particle accelerator fields.
What kind of interaction receives high and low ratings in Oral Proficiency Interviews?
Authors: Seedhouse Paul 
Published: November 2012

AbstractBased on a Conversation Analysis (CA) of a corpus of Oral Proficiency Interviews (OPI), the study asks what kind of interaction receives high and low ratings in OPIs. The discussion focuses on issues of interactional organisation, considering turn-taking, sequence, repair and topic development in relation to candidate scores. The study presents findings of two funded studies of the International English Language Testing System (IELTS) Speaking Test (IST), which is one part of IELTS, a major international English proficiency test.The article explains how interaction in the IST is organised in interactional terms and how this organisation generates opportunities to differentiate high- and low-scoring interaction. The study then lists the interactional characteristics of high-scoring and low-scoring tests, based on an inductive search through the database and analysis of the micro-interaction. Extracts are presented to support characterisations. Differences in score correlate to the following interactional differences in Parts 1 and 3 of the IST: ability to answer the question, engage with and develop a topic coherently, amount of trouble and repair, lexical choice, and identity construction. In Part 2 of the IST, length of turn may also be related to score.
The role of Rab GTPases in the transport of vacuoles containingLegionella pneumophilaandCoxiella burnetii
Authors: Hardiman Camille A. , McDonough Justin A. , Newton Hayley J. , Roy Craig R. 
Published: November 2012

Intracellular pathogens survive in eukaryotic cells by evading a variety of host defences. To avoid degradation through the endocytic pathway, intracellular bacteria must adapt their phagosomes into protective compartments that promote bacterial replication. Legionella pneumophila and Coxiella burnetii are Gram-negative intracellular pathogens that remodel their phagosomes by co-opting components of the host cell, including Rab GTPases. L. pneumophila and C. burnetii are related phylogenetically and share an analogous type IV secretion system for delivering bacterial effectors into the host cell. Some of these effectors mimic eukaryotic biochemical activities to recruit and modify Rabs at the vacuole. In the present review, we cover how these bacterial species, which utilize divergent strategies to establish replicative vacuoles, use translocated proteins to manipulate host Rabs, as well as exploring which Rabs are implicated in vacuolar biogenesis in these two organisms.
How Bugs Kill Bugs: Progress and Challenges in Bacteriocin Research
Authors: Penfold Christopher N. , Walker Daniel , Kleanthous Colin 
Published: November 2012

A Biochemical Society Focused Meeting on bacteriocins was held at the University of Nottingham on 16–18 July 2012 to mark the retirement of Professor Richard James and honour a scientific career of more than 30 years devoted to an understanding of the biology of colicins, bacteriocins produced by Escherichia coli. This meeting was the third leg of a triumvirate of symposia that included meetings at the Île de Bendor, France, in 1991 and the University of East Anglia, Norwich, U.K., in 1998, focused on bringing together leading experts in basic and applied bacteriocin research. The symposium which attracted 70 attendees consisted of 18 invited speakers and 22 selected oral communications spread over four themes: (i) Role of bacteriocins in bacterial ecology, (ii) Mode of action of bacteriocins, (ii) Mechanisms of bacteriocin import across the cell envelope, and (iv) Biotechnological and biomedical applications of bacteriocins. Speakers and poster presenters travelled from around the world, including the U.S.A., Japan, Asia and Europe, to showcase the latest developments in their scientific research.
Colicin translocation across the Escherichia coli outer membrane
Authors: Housden Nicholas G. , Kleanthous Colin 
Published: November 2012

We are investigating how protein bacteriocins import their toxic payload across the Gram-negative cell envelope, both as a means of understanding the translocation process itself and as a means of probing the organization of the cell envelope and the function of the protein machines within it. Our work focuses on the import mechanism of the group A endonuclease (DNase) colicin ColE9 into Escherichia coli, where we combine in vivo observations with structural, biochemical and biophysical approaches to dissect the molecular mechanism of colicin entry. ColE9 assembles a multiprotein ‘translocon’ complex at the E. coli outer membrane that triggers entry of the toxin across the outer membrane and the simultaneous jettisoning of its tightly bound immunity protein, Im9, in a step that is dependent on the protonmotive force. In the present paper, we focus on recent work where we have uncovered how ColE9 assembles its translocon complex, including isolation of the complex, and how this leads to subversion of a signal intrinsic to the Tol–Pal assembly within the periplasm and inner membrane. In this way, the externally located ColE9 is able to ‘connect’ to the inner membrane protonmotive force via a network of protein–protein interactions that spans the entirety of the E. coli cell envelope to drive dissociation of Im9 and initiate entry of the colicin into the cell.
J. S. Mill on Poetry and Rhetoric
Authors: Whedbee Karen E. 
Published: November 2012

Abstract
In his essay “What is Poetry ?”(1833), John Stuart Mill described the difference between rhetoric and poetry using the antithesis, “rhetoric is heard; poetry is overheard.” In the twentieth century, scholars from the field of Speech Communication appropriated Mill's words as justification for the separation of Speech Communication (and rhetorical criticism) from English (and literary criticism). This essay argues that twentieth-century scholars misunderstood Mill's meaning. They failed to recognize that, for Mill, the key issue was not the frequently quoted distinction between rhetoric and poetry but a more problematic distinction between art and science.
“Speech is a Powerful Lord”: Speech, Sound, and Enchantment in Greek Oratorical Performance
Authors: Johnstone Christopher Lyle 
Published: November 2012

AbstractThe performative dimension of oral rhetoric has been a central concern of theorists throughout the history of the tradition. Awareness of the persuasive power of the human voice is especially conspicuous in the teachings of Gorgias of Leontini. When he claims that “speech is a powerful lord,” Gorgias articulates a profound insight into how the human mind and body respond to sounds produced by the voice. By examining Gorgias' views of the potency of speech in the context of the oral, poetic tradition of ancient Greece, we can appreciate more fully the sources of this insight. Moreover, contemporary research in psycho-physiology suggests that Gorgias grasped an important dimension of the human mind's fundamental nature.
Style, Character, and Persuasion in Aristotle's Rhetoric
Authors: Bruss Kristine , Graff Richard 
Published: November 2012

AbstractAristotle's Rhetoric leaves a number of unanswered questions, among them the nature of the relationship between verbal style and êthos, or character, as a means of persuasion. Statements throughout the Rhetoric suggest a connection between manner of expression and persuasive character, but Aristotle's ideas in this area are underdeveloped. Here we argue that Aristotle's stylistic theory, while not demonstrably inconsistent with the technical proof through character, cannot be made to conform neatly with it in most salient respects. Though Aristotle does not explicit y identify style as a means through which the speaker may convey the impression that he possesses positive intellectual or moral qualities, he does recognize a role for lexis in the expression of generic character traits and is aware that an inappropriate style will damage the speaker's credibility. Hence, attention to style is important for the presentation of a plausible êthos and, in this limited respect, style does contribute to the maintenance of persuasive character. This conclusion must be inferred from passing remarks in the Rhetoric. The absence of a more fully developed theory is curious in light of the availability of examples from the discourse of Attic logographers like Lysias, a speechwriter universally praised by later critics for his mastery of ethopoeia(character portrayal).
Acting Up: Drama and the Rhetorical Education of Progressive-Era Teachers at Three Massachusetts State Normal Schools
Authors: Rothermel Beth Ann 
Published: November 2012

Abstract
This essay considers the diverse pedagogical purposes the study of drama served in the rhetorical preparation of teachers at three progressive-era normal schools for women, the Framingham, Westfield, and Salem State Normal Schools. Drawing on scholarship and archival materials, I argue that these normal schools both introduced future teachers to drama as a tool to help their pupils learn and employed dramatic activity as a means to prepare future teachers for their lives in the classroom. Through work in drama, future teachers made explicit connections between learning and playmaking, pedagogy and theatrics, teaching and performance.
The Rhetorical Dynamics of Judicial Situations: Joseph Story, Ciceronian Rhetoric, and the Judicial Response to American Slavery
Authors: O'Rourke Sean Patrick 
Published: November 2012

Abstract
This essays offers a rhetorical interpretation of judicial opinions Joseph Story wrote in four U.S. Supreme Court cases concerned with the slavery question: U.S. v. La Jeune Eugenie (1822), Groves v. Slaughter (1841), U.S. v. Amistad (1841), and Prigg v. Pennsylvania (1842). I argue that Story, a jurist trained in the intellectual traditions of the early republic, performed judicial argument as a kind of rhetorical action dependent upon Ciceronian controversia, a mental habit of arguing pro et contra on any matter in dispute. In consequence of this approach to judicial argument, Story's opinions do not represent a choice between positive law or natural law, neither do they represent a commitment to legal instrumentalism or legal formalism; rather they present controversial responses to rhetorical situations broadly conceived.
Invention in James M. Hoppin'sHOMILETICS: Scope and Classicism in Late Nineteenth-Century American Rhetoric
Authors: Whitburn Merrill D. 
Published: November 2012

AbstractAlthough conventional views about late nineteenth-century rhetoric highlight a shift from oratory to composition and from classical rhetoric to a “new” rhetoric with origins in Scottish rhetoricians (with a loss of scholarship and quality), James M. Hoppin's Homiletics can be grouped with an increasing number of works that complicate such views. Hoppin focuses on oratory; reveals an especially broad and scholarly knowledge of classical, religious, and foreign rhetorics; uses a complex of ideas called “uniformitarianism” to justify his primary focus on classical rhetoric; and achieves high quality. His concept of invention has both classical and Christian roots in a complex relationship reflecting both scope and narrowness.
Effectiveness of professionally‐guided physical education on fitness outcomes of primary school children
Authors: Lucertini Francesco , Spazzafumo Liana , De Lillo Francesca , Centonze Debora , Valentini Manuela , Federici Ario 
Published: November 2012

AbstractPhysical education (PE) at school is an important starting point for long‐term interventions improving quality of life in elderly. To evaluate the effectiveness of professionally led PE on motor and health‐related abilities of Italian primary schoolchildren (3rd–5th graders), three schools were assigned to the experimental groups “A” (38 pupils, 17 M, 21 F) and “B” (37 pupils, 16 M, 21 F), and to control group “C” (26 pupils, 18 M, 8 F). All groups underwent a six‐month, twice‐a‐week (60 min each session) PE intervention. The PE program of the EGs was age‐tailored, included strength training and was administered by specialised teachers. Group A and B programs differed in the strength training devices used, while they were identical in terms of training load. The control group program was not structured and administered by generalist teachers. At baseline and follow‐up, children underwent a motor and health‐related abilities test battery. At follow‐up, children in group C gained significantly more weight than children in the EGs and scored significantly less than the children in the EGs in the following assessments: counter movement jump (C:+0.15% vs. A:+4.1% and B:+6.99%), plate tapping (C:+13.56% vs. A:+19.37% and B:+36.12%), sit‐and‐reach (C:−311.15% vs. B:+409.57%), pinch strength (C:+2.39% vs. B:+10.83, on average) and sit‐up (C:+29.69% vs. A:+72.61%). In conclusion, specialist‐led pupils demonstrated greater increases in some motor and health‐related abilities tests compared to generalist‐led peers, while different strength training devices produced comparable increases of strength in both EGs.