bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining Network Pharmacology and Experimental Verification to Ascertain the Mechanism of Action of Asparagus officinalis Against the Brain Damage Caused by Fluorosis
Authors: Wang Feiqing , Liu Yang , Li Yanju , Yang Xu , Zhao Jianing , Yang Bo , Tang Dongxin , Zhang Chike , He Zhixu , Ming Dong , Zhu Xiaodong 
Published: July 2024

ABSTRACTAsparagus officinalis (ASP) has antioxidation, anti‐inflammatory, antiaging, and immune system‐enhancing effects. We explored the preventive and therapeutic consequences of ASP on the brain damage elicited by fluorosis through network pharmacology and in vivo experimental validation. We ascertained the pharmaceutically active ingredients and drug targets of ASP from the Traditional Chinese Medicine Systems Pharmacology database, predicted the disease targets of fluorosis‐induced brain injury using GeneCards and Online Mendelian Inheritance in Man databases, obtained target protein–protein interaction networks in the Search Tool for the Retrieval of Interacting Genes/Proteins database, used Cytoscape to obtain key targets and active ingredients, and conducted enrichment analyses of key targets in the Database for Annotation, Visualization and Integrated Discovery. Enrichment analyses showed that “mitogen‐activated protein kinase” (MAPK), “phosphoinositide 3‐kinase/protein kinase B” (PI3K‐Akt), “nuclear factor‐kappa B” (NF‐κB), and the “neurotrophin signaling pathway” were the most enriched biological processes and signaling pathways. ASP could alleviate fluorosis‐based injury, improve brain‐tissue damage, increase urinary fluoride content, and improve oxidation levels and inflammatory‐factor levels in the body. ASP could also reduce dental fluorosis, bone damage, fluoride concentrations in blood and bone, and accumulation of lipid peroxide. Upon ASP treatment, expression of silent information regulator (SIRT)1, brain‐derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), MAPK, NF‐κB, PI3K, Akt, and B‐cell lymphoma‐2 in rat brain tissue increased gradually, whereas that of Bax, caspase‐3, and p53 decreased gradually. We demonstrated that ASP could regulate the brain damage caused by fluorosis through the SIRT1/BDNF/TrkB signaling pathway, and reported the possible part played by ASP in preventing and treating fluorosis.
Indoor Air Quality: Bibliometric Analysis of the Published Literature Between 2018 and 2023
Authors: Nazli Siti Nurshahida , Vilcins Dwan , Sly Peter D. , Razak Azli Abd , Sabri Nurhidayah , Ibrahim Tengku Nilam Baizura Tengku 
Published: July 2024

ABSTRACTThis bibliometric study employs a rigorous approach to scrutinize and visually represent the existing body of literature on indoor air quality (IAQ). Utilizing the Scopus collection database, we conducted an exhaustive exploration of published research literature in the IAQ field. The study involves a thorough visual analysis using Harzing's Publish and Perish and VOSviewer software programs, examining parameters such as citations, publication year, journals, authors, research institutions, countries, and research topics. A total of 1729 pieces of literature related to IAQ research from 2018 to 2023 were retrieved. The dominant formats were articles and conference papers, underscoring their significance in IAQ documentation. Primary subject areas included “Engineering” and “Environmental Science,” highlighting the multidisciplinary nature of IAQ studies. The upward trend in IAQ publications, reaching 330 articles in 2023, emphasizes the growing importance of this field. However, citation impact varied, emphasizing the need to assess research quality alongside quantity. Global distribution identified leading countries, including the United States, China, and the United Kingdom, which were also top contributors in co‐authorship and country‐level analyses. The top journals were “Building and Environment” and “Sustainable Cities and Society,” showcasing varying publication and citation powers. Notable impactful articles in the IAQ domain were led by Agarwal et al. and Van Tran, Park, and Lee. Keyword co‐occurrence analysis identified thematic clusters, with keywords such as “Indoor Air Quality (IAQ),” “Air Quality,” and “Indoor Air Pollution” dominating the literature. Through a comprehensive analysis of published literature, this study provides a visual representation of studies with significant contributions to the IAQ field, offering insights into its development and changes from 2018 to 2023. The findings also guide future IAQ research directions.
Remission of diabetes mellitus induced by prednisolone in combination with cyclosporine toxicity in a cat
Authors: Cha Sijin , Koo Yoonhoi , Choi Yujin , Chae Yeon , Lee Dohee , Yun Taesik , Yang Mhan‐Pyo , Kang Byeong‐Teck , Kim Hakhyun 
Published: July 2024

AbstractA 6‐year‐old spayed female domestic short‐hair cat was presented for primary complaints of anorexia and lethargy. The cat was being treated with cyclosporine (25 mg/cat, PO q24h) and prednisolone (1 mg/kg, PO q12h) for feline hypersensitivity dermatitis and inflammatory bowel disease for 1 year, wherein prednisolone was withdrawn 2 weeks prior to presentation. At presentation, dehydration, hyperglycaemia, ketonaemia, increased fructosamine, glucosuria, ketonuria and metabolic acidosis were observed. The cat was diagnosed with diabetic ketoacidosis (DKA). Immediate treatments with insulin continuous‐rate infusion and intravenous fluid therapy were initiated. A serum cyclosporine concentration was >2100 ng/mL, indicating cyclosporine toxicity. Cyclosporine was discontinued immediately. The cat's acidosis and ketonaemia were resolved within a week, allowing a switch from insulin continuous‐rate infusion to subcutaneous glargine (1 IU/cat), which was eventually discontinued due to persistent normoglycaemia 12 days after initial presentation. Hyperglycaemia was not observed for 28 days thereafter without insulin, indicating remission of diabetes mellitus. This report suggests that using prednisolone, particularly immune suppressive doses, could be problematic in cats receiving long‐term cyclosporine therapy. Additionally, diabetic cats receiving immune‐suppressive agents can possibly achieve diabetic remission after surviving DKA through regular monitoring of blood glucose concentration, elimination of prednisolone and intensive blood glucose management.
Levopositioned caudal vena cava and circumcaval left ureter with subsequent hydronephrosis and hydroureter in a dog
Authors: Woolley Eleanor L. E. , Hogan Kathryn , House Arthur K. 
Published: July 2024

AbstractThe presentation and investigation of a levopositioned caudal vena cava, a rare congenital vascular abnormality seen mainly in Bernese Mountain Dogs, which resulted in ureteral compression, hydronephrosis and hydroureter. Surgical transection, transposition and anastomosis were performed to reposition the circumcaval ureter. A 19‐month‐old male neutered Bernese Mountain Dog was presented with a 13‐month history of vague signs including intermittent abdominal pain, inappetence and diarrhoea, which were poorly responsive to medical management. Abdominal ultrasound revealed left‐sided hydronephrosis and hydroureter. Further investigation included abdominal computed tomography and pre‐ and post‐intravenous iodinated contrast, which revealed a levopositioned caudal vena cava with associated ureteral displacement to a circumcaval position, resulting in ureteral compression and proximal dilation affecting both the proximal ureter and the left kidney. The patient was also found to have concomitant gall bladder agenesis. Surgery was performed to transect, transpose and anastomose the ureter in a normal anatomical position, and the patient made an excellent clinical recovery. All gastrointestinal signs resolved within 2 weeks of surgery and remained resolved 12 months later. Follow‐up ultrasound and pyelography were performed at 4‐month post‐surgery, revealing a mild improvement in the hydronephrosis and hydroureter. Although rare, circumcaval ureter should be considered a differential in dogs presenting with hydroureter and hydronephrosis, especially Bernese Mountain Dogs.
The 1/4-BPS building blocks of brane interactions
Authors: Eckardt Ben , Li Yixuan 
Published: July 2024

Abstract
We study, from the perspective of supersymmetry and space-time Killing spinors, the local brane densities involved in 1/4-BPS intersecting brane systems. In particular, we classify the possible local brane structures that have maximal (16) supersymmetries in 1/4-BPS intersecting brane backgrounds. Applied to BPS black holes, this classification reveals the allowed local microstructure for pure microstates. We further use these structures with local 16 supersymmetries as building blocks to generalise to 1/8-BPS systems. Moreover, we give examples of 1/8-BPS black holes for which the local supersymmetries are compatible with the combination of different entropy-generating effects from brane interaction. Finally, applying our classification to BPS domain walls, we illustrate how our formalism may possibly describe the local picture of the Hanany-Witten effect.
Subvolume method for SU(2) Yang-Mills theory at finite temperature: topological charge distributions
Authors: Yamada Norikazu , Yamazaki Masahito , Kitano Ryuichiro 
Published: July 2024

Abstract
We apply the previously-developed sub-volume method to study the θ-dependence of the four-dimensional SU(2) Yang-Mills theory at finite temperature. We calculate the first two coefficients, the topological susceptibility χ and the fourth cumulant b2, in the θ-expansion of the free energy density around the critical temperature (Tc) for the confinement-deconfinement transition. Lattice calculations are performed with three different spatial sizes 243, 323, 483 to monitor finite size effects, while the temporal size is fixed to be 8. The systematic uncertainty associated with the sub-volume extrapolation is studied with special care. The sub-volume method allows us to determine the values of b2 much more accurately than the standard full-volume method, and we successfully identify the temperature dependence of b2 around Tc. Our numerical results suggest that the θ-dependence of the free energy density near θ = 0 changes from 4χ(1 − cos(θ/2)) to χ(1 − cos θ) as the temperature crosses Tc.
Rechtsmedizinische Lehrtätigkeit an den Hochschulen mit Polizeistudiengängen in Deutschland
Authors: Lemke V. , Clas S. , Metzler K. , Heide S. , Hollmann T. 
Published: July 2024

ZusammenfassungHintergrund und FragestellungAn den rechtsmedizinischen Universitätsinstituten in Deutschland bildet die Vermittlung fachspezifischer Lehrinhalte an die Polizei häufig einen traditionellen Bestandteil der Lehrtätigkeit. Konkrete Darstellungen zur Ausgestaltung dieser Lehrveranstaltungen liegen bislang nur vereinzelt vor.Ziel der ArbeitVor dem Hintergrund der zunehmenden Bedeutung moderner hochschuldidaktischer Aspekte in allen Studienrichtungen konnte in einer deutschlandweiten Studie erstmals die aktuelle Situation der rechtsmedizinischen Lehrtätigkeit an den Polizeihochschulen erfasst werden.Material und MethodenIm Verlauf des Jahres 2023 wurden alle 19 deutschen Hochschulen mit Polizeistudiengängen und potenziell möglicher Vermittlung von rechtsmedizinischen Lehrinhalten zu den formalen und inhaltlichen Aspekten der derzeitigen Lehrsituation schriftlich befragt.ErgebnisseAn 17 der 19 Hochschulen werden rechtsmedizinische Lehrinhalte vermittelt. Zumeist erfolgt diese Lehrtätigkeit über Kooperationsverträge oder Lehraufträge mit rechtsmedizinischen Einrichtungen oder sogar mit eigenen rechtsmedizinischen Professuren. Teilweise werden diese Lehrinhalte auch über nichtmedizinische Dozent*innen vermittelt. Im Umfang und in der konkreten Ausgestaltung der angewendeten Lehr‑, Lern- und Prüfungsformate besteht ein heterogenes Spektrum. So dominieren z. B. frontale Unterrichtsformate und faktenbasierte Prüfungen.Diskussion und SchlussfolgerungIm Ergebnis der Studie zeigt sich eine weite Verbreitung rechtsmedizinischer Lehrinhalte an den Polizeihochschulen. Dabei ist jedoch die teilweise Vermittlung von rechtsmedizinischen Kernthemen durch nichtmedizinische Dozent*innen kritisch zu hinterfragen. Da aber gleichzeitig eine zunehmende Nachfrage nach den bereits jetzt sehr umfangreichen rechtsmedizinischen Lehrangeboten für andere Studienrichtungen bzw. Berufsgruppen besteht, ist für die Lösung dieser Problematik eine Ausbildung von zusätzlichen, fachlich und didaktisch gut geschulten rechtsmedizinischen Lehrkräften unverzichtbar. Damit könnte auch eine Weiterentwicklung der Lehre innerhalb der Polizeiausbildung mit stärkerer Fokussierung auf praktisch orientierte Formate ermöglicht werden.
Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury
Authors: Martínez-Torres Ari Misael , Morán Julio 
Published: July 2024

AbstractBrain edema is a critical complication arising from stroke and traumatic brain injury (TBI) with an important impact on patient recovery and can lead to long-term consequences. Therapeutic options to reduce edema progression are limited with variable patient outcomes. Aquaporin 4 (AQP4) is a water channel that allows bidirectional water diffusion across the astrocyte membrane and participates in the distinct phases of cerebral edema. The absence or inhibition of this channel has been demonstrated to ameliorate edema and brain damage. The endocannabinoid system (ECS) is a neuromodulator system with a wide expression in the brain and its activation has shown neuroprotective properties in diverse models of neuronal damage. This review describes and discusses the major features of ECS and AQP4 and their role during brain damage, observing that ECS stimulation reduces edema and injury size in diverse models of brain damage, however, the relationship between AQP4 expression and dynamics and ECS activation remains unclear. The research on these topics holds promising therapeutic implications for the treatment of brain edema following stroke and TBI.
Degloving intramuscular injuries of the semimembranosus and adductor longus muscles in adolescent soccer players
Authors: Bordalo Marcelo , de Aysa Patricia Nunez , Helito Paulo Victor Partezani , Djadoun Mohamed Abdelatif , Gulde Maria Lua Sampaio , Alonso Juan Manuel 
Published: July 2024

Abstract
Degloving muscle injury was described for the rectus femoris where the inner bipennate component is dissociated from its superficial unipennate component. The semimembranosus muscle displays a distinctive dual morphology, featuring both unipennate and bipennate muscle fibers. Nevertheless, this specific tear pattern has not been previously documented. Conversely, the adductor longus muscle showcases an elongated intramuscular tendon segment, indicating a multipennate morphology. We present two separate cases of previous undescribed degloving injuries of the semimembranosus and the adductor longus in teenage soccer players with MRI and ultrasound diagnosis, ultrasound-guided hematoma aspiration, and recovery timelines for return-to-play.
Personalized risk prediction for prolonged ileus after minimally invasive colorectal cancer surgery: in-depth risk factor analysis and model development
Authors: Xiu Wenchao , Zhang Yalin , Man Yifan , Yu Zongping , Ren Dawei 
Published: July 2024

Abstract
Purpose
Despite the increasing preference for minimally invasive surgery for colorectal cancer (CRC), the incidence of prolonged postoperative ileus (PPOI) remains high. Thus, this study aimed to identify risk factors for PPOI in patients with CRC who underwent minimally invasive surgery (MICRS) and to develop a practical nomogram for predicting individual PPOI risk.

Methods
A consecutive series of 2368 patients who underwent MICRS between 2013 and 2023 at two tertiary academic centers were retrospectively studied. Using the data from 1895 patients in the training cohort, a multivariable logistic regression model was employed to select significant variables for the construction of a best-fit nomogram. The nomogram was internally and externally validated.

Results
PPOI occurred in 9.5% of patients. Six independent risk factors were identified to construct a nomogram: advanced age (OR 1.055, P = 0.002), male sex (OR 2.914, P = 0.011), age-adjusted Charlson comorbidity index ≥ 6 (OR 2.643, P = 0.025), preoperative sarcopenia (OR 0.857, P = 0.02), preoperative prognostic nutritional index (OR 2.206, P = 0.047), and intraoperative fluid overload (OR 2.227, P = 0.045). The AUCs of the model for predicting PPOI in the training and external validation cohorts were 0.887 and 0.838, respectively. The calibration curves demonstrated excellent consistency between the nomogram-predicted and observed probabilities in both cohorts. Individuals with a total nomogram score of < 197 or ≥ 197 were considered to be at low or high risk for PPOI, respectively.

Conclusions
The integrated nomogram we developed could provide personalized risk prediction of PPOI after MICRS. This quantification enables surgeons to implement personalized prevention strategies, thereby improving patient outcomes.
Spatiotemporal analysis of multi-scale cell structure in spheroid culture reveals hypertrophic chondrocyte differentiation
Authors: Tomida Kosei , Kim Jeonghyun , Maeda Eijiro , Adachi Taiji , Matsumoto Takeo 
Published: July 2024

Abstract3D cell culture has emerged as a promising approach to replicate the complex behaviors of cells within living organisms. This study aims to analyze spatiotemporal behavior of the morphological characteristics of cell structure at multiscale in 3D scaffold-free spheroids using chondrogenic progenitor ATDC5 cells. Over a 14-day culture period, it exhibited cell hypertrophy in the spheroids regarding cellular and nuclear size as well as changes in morphology. Moreover, biological analysis indicated a signification up-regulation of normal chondrocyte as well as hypertrophic chondrocyte markers, suggesting early hypertrophic chondrocyte differentiation. Cell nuclei underwent changes in volume, sphericity, and distribution in spheroid over time, indicating alterations in chromatin organization. The ratio of chromatin condensation volume to cell nuclear volume decreased as the cell nuclei enlarged, potentially signifying changes in chromatin state during hypertrophic chondrocyte differentiation. Our image analysis techniques in this present study enabled detailed morphological measurement of cell structure at multi-scale, which can be applied to various 3D culture models for in-depth investigation.
Bibliometric analysis of research trends in the relationship between frailty and neoplasms over the past decade
Authors: Chen Yuqin , Chen Xiaoping , Zhong Lifang , Lu Huiming , Zhang Huiting , Jiang Mengxiao 
Published: July 2024

Abstract
Background
The relationship between frailty and neoplasms has attracted increasing attention from researchers in recent years. This study aims to identify current research hotspots and status in this field through bibliometric and visualization analysis.

Methods
Literature on the relationship between frailty and neoplasms, meeting the inclusion criteria, was collected from the Core Collection. Bibliometric analysis and visualization were performed using WoS, VOSviewer, and CiteSpace.

Results
Our study included 7410 documents on frailty and neoplasms, authored by 43,605 researchers from 9478 institutions across 115 countries, and published in 2067 journals. The USA emerged as the most productive and influential country in this field, with 3059 publications and 89,319 citations. The University of Texas MD Anderson Cancer Center and Mayo Clinic were recognized as the most productive institution and the institution with the highest citation count, respectively. The Journal of Geriatric Oncology was the leading publisher. Kirsten K Ness and James L Kirkland were identified as the most productive and most cited authors, respectively. Cluster analysis identified five key areas: body condition and nutrition, quality of life, frailty, mortality and care, and the elderly and frailty.

Conclusion
The relationship between frailty and neoplasms remains a contentious and frequently discussed topic. Our findings indicate that research primarily focuses on cancer, the elderly, clinical trials, adverse health outcomes, frailty assessment, and nutrition.
Neurophysiological evidence for the overview effect: a virtual reality journey into space
Authors: van Limpt-Broers H. A. T. , Postma M. , van Weelden E. , Pratesi S. , Louwerse M. M. 
Published: July 2024

AbstractThe Overview Effect is a complex experience reported by astronauts after viewing Earth from space. Numerous accounts suggest that it leads to increased interconnectedness to other human beings and environmental awareness, comparable to self-transcendence. It can cause fundamental changes in mental models of the world, improved well-being, and stronger appreciation of, and responsibility for Earth. From a cognitive perspective, it is closely linked to the emotion of awe, possibly triggered by the overwhelming perceived vastness of the universe. Given that most research in the domain focuses on self-reports, little is known about potential neurophysiological markers of the Overview Effect. In the experiment reported here, participants viewed an immersive Virtual Reality simulation of a space journey while their brain activity was recorded using electroencephalography (EEG). Post-experimental self-reports confirmed they were able to experience the Overview Effect in the simulated environment. EEG recordings revealed lower spectral power in beta and gamma frequency bands during the defining moments of the Overview Effect. The decrease in spectral power can be associated with reduced mental processing, and a disruption of known mental structures in this context, thereby providing more evidence for the cognitive effects of the experience.
Comparing groups of units through composite indicators in a non-convex approach: corporate social responsibility for the food and beverage manufacturing industry
Authors: Kapelko Magdalena , Ortiz Lidia , Aparicio Juan 
Published: July 2024

AbstractThis paper compares the performance of groups of units by composing indicators of corporate social responsibility (CSR) from an efficiency and productivity perspective, applicable across various industries. From a methodological perspective, our work extends the traditional input-oriented Benefit-of-the-Doubt (BoD) model in the multiplier form, by first adapting it to accommodate the non-convexities of the production set, and second, by innovatively applying it to compare indicators across groups of firms. This adaptation, pioneered in our study, leverages the framework previously established in the literature to address more complex scenarios. From an empirical perspective, we contribute by comparing the efficiency and productivity in CSR activities of food and beverage companies across regions of Europe, the United States and Canada, and Asia–Pacific over the period 2009–2018. The paper reveals that USA-Canadian firms tend to perform best with respect to CSR, followed by European firms, and that Asian-Pacific firms achieve the worst efficiency and productivity results. The study also shows that regional catching up in CSR productivity occurred over the analyzed period.