bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flood‐related skin diseases: a literature review
Authors: Tempark Therdpong , Lueangarun Saoraya , Chatproedprai Susheera , Wananukul Siriwan 
Published: October 2015

AbstractFlood is one of the most common natural disasters, which commonly occurs in all parts of the world. The effects of the disasters considerably become enormous problems to overall public health systems. Flood‐related skin diseases are a portion of these consequences presenting with cutaneous manifestations and/or signs of systemic illnesses. We conducted a systematic literature review of research publications relating to flooding and skin diseases. The purpose of this review was to provide dermatologists as well as general practitioners with comprehensive conditions of flood‐related skin diseases and suggested treatments. Moreover, we categorized these flood‐related diseases into four groups comprising inflammatory skin diseases, skin infections, traumatic skin diseases, and other miscellaneous skin diseases in a bid to implement early interventions and educate, prevent, and efficaciously handle those skin diseases under such a catastrophic situation so that better treatment outcomes and prevention of further complications could be ultimately achieved and accomplished.
Theological Reflection on the Ecological Problem in Relation to the Accra Confession: An East Asian Perspective
Authors: Lam Jason 
Published: October 2015

AbstractCompared with the declarations related to ecological concerns produced by other ecclesial bodies, the Accra Confession is not a latecomer.2 But in view of the increasingly severe situation the world is now facing (for example, the nuclear threat, from Chernobyl to Three Mile Island and, recently, Fukushima), it seems that the “prophetic” voice from the Christian church always comes too late. Be that as it may, every Christian should share the common mission of being a peacemaker with all of God's creation, despite the groaning of the earth in face of all sorts of threat and injustice. In this paper, I first review the Accra Confession in relation to ecological concerns. Then, as it seems to me that the interfaith perspective has received less attention, I develop a theological reflection based on my East Asian cultural resources in order to make a contribution to the global problem from a regional stance. Finally I provide some practical suggestions.
‘Difficult to diagnose’ desmoid tumours: a potential role for CTNNB1 mutational analysis
Authors: Colombo Chiara , Bolshakov Svetlana , Hajibashi Shohrae , Lopez‐Terrada Lola , Wang Wei‐Lien , Rao Priya , Benjamin Robert S , Lazar Alexander J , Lev Dina 
Published: October 2015

Colombo C, Bolshakov S, Hajibashi S, Lopez‐Terrada L, Wang W‐L, Rao P, Benjamin R S, Lazar A J & Lev D (2011) Histopathology59, 336–340‘Difficult to diagnose’ desmoid tumours: a potential role for CTNNB1 mutational analysisAims:  The utility of CTNNB1 (encoding β‐catenin) genotyping for diagnosing sporadic desmoid tumours (DT) when traditional clinicopathological parameters were inconclusive was evaluated.Methods and results:  Cases included were: (i) new primary lesions where initial DT diagnosis was inconclusive; and (ii) possible recurrent DT versus scar. Formalin‐fixed paraffin‐embedded (FFPE) tissues were obtained via needle biopsy or a surgical excision (57 specimens) as part of initial assessment. DNA extraction, CTNNB1 exon 3 amplification and sequencing were conducted in a Clinical Laboratory Improvement Amendments of 1988 (CLIA)‐approved molecular diagnostics laboratory. For patients with no previous DT history (n = 47) sequencing identified mutations in 30 (64%), substantiating DT diagnosis. In biopsies with non‐mutated (NM) CTNNB1 (n = 17) the test was inconclusive; in seven of these, a diagnosis of DT was strongly favoured in the subsequent surgical resection specimen. Ten patients with previously resected DT were evaluated; mutation was identified in six cases (60%), indicating DT over scar. In two (20%) with primary tumours harbouring CTNNB1 mutation no mutation was found, favouring scar over DT; the other two NM‐CTNNB1 cases (20%) were inconclusive.Conclusions:  CTNNB1 genotyping can be very useful in ‘difficult to diagnose’ lesions when the differential diagnosis includes DT. Recognizing inherent test limitations, the presence of CTNNB1 mutation can inform the therapeutic approach.
Prognostic value of ABCG2 in moderately and poorly differentiated intrahepatic cholangiocarcinoma
Authors: Larbcharoensub Noppadol , Sornmayura Pattana , Sirachainan Ekaphop , Wilasrusmee Chumpon , Wanmoung Harirak , Janvilisri Tavan 
Published: October 2015

Larbcharoensub N, Sornmayura P, Sirachainan E, Wilasrusmee C, Wanmoung H & Janvilisri T  (2011) Histopathology59, 235–246Prognostic value of ABCG2 in moderately and poorly differentiated intrahepatic cholangiocarcinomaAims:  Intrahepatic cholangiocarcinoma (ICC) is a primary hepatic malignancy derived from cholangiocytes. The survival rate of ICC patients is very low, and conventional chemotherapy is not effective in prolonging long‐term survival. Adenosine 5′‐triphosphate (ATP)‐binding cassette (ABC) transporters mediate the transport of various substances in several cellular processes. The expression of ABCB1, ABCC1 and ABCG2 has been implicated in multidrug resistance and poor prognosis in several types of cancer. The aim of this study was to examine their expression in normal cholangiocytes and ICC tissues.Methods and results:  Immunohistochemistry was employed to evaluate the expression of these transporters in 60 cases of ICC with respect to clinicopathological features and patient outcome. The proportions of cases with loss of ABCB1, ABCC1 and ABCG2 expression were 93.3%, 68.3% and 50%, respectively. Only the loss of ABCG2 was related to a worse prognosis (P = 0.031), and was associated with lymph node involvement (P = 0.003) and higher tumour grade (P = 0.028). Furthermore, multivariate analysis showed that the loss of ABCG2 expression was an independent prognostic factor in patients with moderately or poorly differentiated ICC (P = 0.02).Conclusions:  These results suggest that ABCG2 may be involved in cholangiocarcinogenesis; the loss of its expression may enhance tumour progression and contribute to aggressive growth of ICC.
Cloning of an octopamine/tyramine receptor and plasticity of its expression as a function of adult sexual maturation in the male moth Agrotis ipsilon
Authors: Duportets L. , Barrozo R. B. , Bozzolan F. , Gaertner C. , Anton S. , Gadenne C. , Debernard S. 
Published: October 2015

AbstractIn the male moth Agrotis ipsilon behavioural response and antennal lobe (AL) neuron sensitivity to the female‐produced sex pheromone increase with age and juvenile hormone (JH) level. We recently showed that the neuromodulator, octopamine (OA), interacts with JH in this age‐dependent olfactory plasticity. To further elucidate its role, we cloned a full cDNA encoding a protein that presents biochemical features essential to OA/tyramine receptor (AipsOAR/TAR) function. The AipsOAR/TAR transcript was detected predominantly in the antennae, the brain and, more specifically, in ALs where its expression level varied concomitantly with age. This expression plasticity indicates that AipsOAR/TAR might be involved in central processing of the pheromone signal during maturation of sexual behaviour in A. ipsilon.
Improving cultural competence education: the utility of an intersectional framework
Authors: Powell Sears Karen 
Published: October 2015

Medical Education 2012: 46:545–551Context  Most US medical schools have instituted cultural competence education in the undergraduate curriculum. This training is intended to improve the quality of care that doctors, the majority of whom are White, deliver to ethnic and racial minority patients. Research into the outcomes of cultural competence training programmes reveals that they have been largely ineffective in improving doctors’ skills. In varied curricular formats, programmes tend to teach group‐specific cultural knowledge, despite the vast heterogeneity of racial and ethnic groups. This cultural essentialism diminishes training effectiveness.Methods  This paper proposes key curriculum content changes and suggests the inclusion of an intersectional framework in the cultural competence curriculum. This framework maintains that racial and ethnic minority groups hold multiple social statuses, called social locations, which interact with one another to uniquely shape the health views, needs and experiences of the individuals within the groups. Social locations include those defined by race, ethnicity, gender, social class and sexuality, which are experienced multiplicatively, not additively, within a particular social context. Cultural competence education must go beyond simplified cultural understandings to explore these more complex meanings. Doctors’ ability to understand, communicate with and treat diverse groups can be vastly improved by applying an intersectional framework in academic research, self‐awareness exercises and clinical training.Results  Integrating an intersectional framework into cultural competency education can better prepare doctors for caring for racial and ethnic minority patients. This paper recommends curriculum elements for the classroom and clinical training that can improve doctor knowledge and skills for caring for diverse groups. Medical schools can use the proposed model to facilitate the development of new educational strategies and learning experiences. These improvements can lead to more equitable care and ultimately diminish disparities in health care. Although these recommendations are designed with US schools in mind, they may improve doctor understanding and care of marginal populations across the world.
Students’ workplace learning in two clerkship models: a multi‐site observational study
Authors: O’Brien Bridget C , Poncelet Ann N , Hansen Lori , Hirsh David A , Ogur Barbara , Alexander Erik K , Krupat Edward , Hauer Karen E 
Published: October 2015

Medical Education 2012: 46:613–624Context  Longitudinal integrated clerkships (LICs) are established, rapidly growing models of education designed to improve the core clinical year of medical school using guiding principles about workplace learning and continuity. This study is the first to report data from direct observations of workplace learning experiences of students on LICs and traditional block clerkships (BCs), respectively.Methods  This multi‐institution study used an observational, work‐sampling methodology to compare LIC and BC students early and late in the core clinical year. Trained research assistants documented students’ activities, participation (observing, with assistance, alone), and interactions every 10 minutes over 4‐hour periods. Each student was observed one to three times early and/or late in the year. Data were aggregated at the student level and by in‐patient or out‐patient setting for BC students. One‐way analysis of variance (anova) was used to compare two groups early in the year (LIC and BC students) and three groups late in the year (LIC, out‐patient BC and in‐patient BC students).Results  Early‐year observations included 26 students (16 LIC and 10 BC students); late‐year observations included 44 students (28 LIC, eight out‐patient BC and eight in‐patient BC students). Out‐patient activities and interactions of LIC and BC students were similar early in the year, but in the later period LIC students spent significantly more time performing direct patient care activities alone (25%) compared with out‐patient (12%) and in‐patient (7%) BC students. Students on LICs were significantly more likely to experience continuity with patients as 34% of their patients returned to them, whereas only 5% of patients did so for out‐patient BC students late in the year.Conclusions  By late year, LIC students engage in patient care more independently and have more opportunities to see clinic patients on multiple occasions than BC students. Consistent with the principles of workplace learning, these findings suggest that yearlong longitudinal integrated education models, that rely mostly on ambulatory settings, afford students greater opportunities to participate more fully in the provision of patient care.
Evaluation of coexistence of the Human Herpesvirus type 8 (HHV‐8) infection and pemphigus
Authors: Meibodi Naser Tayyebi , Nahidi Yalda , Mahmoudi Mahmoud , Javidi Zari , Rastin Maryam , Sheikh Akram , Esmaeeli Habib Allah 
Published: October 2015

AbstractBackground  Human Herpesvirus type 8 (HHV‐8) is a new member of the herpes virus family, first found in the tissue of acquired immune deficiency syndrome (AIDS)‐related Kaposi’s sarcoma. Environmental factors including viral infection may play a role in the onset and/or development of pemphigus. Some studies based on polymerase chain reaction findings suggest an association between HHV‐8 and pemphigus. The aim of this study is investigation of the association of pemphigus with HHV‐8 and the relationship between inflammatory and acantholytic cells with HHV‐8 infection.Methods  Tissue‐extracted DNA from 41 paraffin‐embedded skin tissues from patients first presenting with pemphigus was tested using nested PCR for the presence of HHV‐8. A total of 37 cases had pemphigus vulgaris (PV) and 4 patients had pemphigus foliaceus (PF). For our control group, normal skin of 21 cosmetic surgery patients were included. Furthermore, microscopic slides with H&E staining were evaluated for the number of inflammatory and acantholytic cells per microscopic field.Results  Skin lesions from 13 of 37 patients (35.1%) with PV and 2 of 4 cases (50%) with PF were positive for HHV‐8 DNA. All specimens in our control group were negative for this virus.Conclusion  HHV‐8 infection might be a contributing factor in the initiation or development of pemphigus.
Cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia
Authors: Ding Wen Yi , Lee Chew Kek , Choon Siew Eng 
Published: October 2015

AbstractBackground  Adverse drug reactions are most commonly cutaneous in nature. Patterns of cutaneous adverse drug reactions (ADRs) and their causative drugs vary among the different populations previously studied.Objective  Our aim is to determine the clinical pattern of drug eruptions and the common drugs implicated, particularly in severe cutaneous ADRs in our population.Materials and Methods  This study was done by analyzing the database established for all adverse cutaneous drug reactions seen from January 2001 until December 2008.Results  A total of 281 cutaneous ADRs were seen in 280 patients. The most common reaction pattern was maculopapular eruption (111 cases, 39.5%) followed by Stevens‐Johnson Syndrome (SJS: 79 cases, 28.1%), drug reaction with eosinophilia and systemic symptoms (DRESS: 19 cases, 6.8%), toxic epidermal necrolysis (TEN: 16 cases, 5.7 %), urticaria/angioedema (15 cases, 5.3%) and fixed drug eruptions (15 cases, 5.3%). Antibiotics (38.8%) and anticonvulsants (23.8%) accounted for 62.6% of the 281 cutaneous ADRs seen. Allopurinol was implicated in 39 (13.9%), carbamazepine in 29 (10.3%), phenytoin in 27 (9.6%) and cotrimoxazole in 26 (9.3%) cases. Carbamazepine, allopurinol and cotrimoxazole were the three main causative drugs of SJS/TEN accounting for 24.0%, 18.8% and 12.5% respectively of the 96 cases seen whereas DRESS was mainly caused by allopurinol (10 cases, 52.6%) and phenytoin (3 cases, 15.8%).Discussion  The reaction patterns and drugs causing cutaneous ADRs in our population are similar to those seen in other countries although we have a much higher proportion of severe cutaneous ADRs probably due to referral bias, different prescribing habit and a higher prevalence of HLA‐B*1502 and HLA‐B*5801 which are genetic markers for carbamazepine‐induced SJS/TEN and allopurinol‐induced SJS/TEN/DRESS respectively.Conclusion  The most common reaction pattern seen in our study population was maculopapular eruptions. Antibiotics, anticonvulsants and NSAIDs were the most frequently implicated drug groups. Carbamazepine and allopurinol were the two main causative drugs of severe ADRs in our population.
Secondary amyloidosis in Indigenous Australians
Authors: Corbett C. L. , Lawton P. D. 
Published: October 2015

AbstractSecondary amyloidosis (AA) is an established consequence of many chronic inflammatory conditions. In the developed world, it is most often the result of rheumatological disease. However, the relative frequency of underlying causes may be different in indigenous populations. We present a case series of three remote‐living, Indigenous Australians found to have pathologically confirmed amyloidosis and renal impairment at diagnosis. The presence of an underlying inflammatory condition was unclear in two cases. The remaining case had established bronchiectasis and suffered rapidly progressive renal impairment at a young age.
A New Test of the Real Interest Rate Parity Hypothesis: Bounds Approach and Structural Breaks
Authors: Bagdatoglou George , Kontonikas Alexandros 
Published: October 2015

AbstractThe real interest rate parity hypothesis is tested using data for the group of seven industrialized countries (G7) over the period 1970–2008. The contribution is two‐fold. First, the paper utilizes the bounds approach in order to overcome uncertainty about the order of integration of real interest rates. Second, a test is made for structural breaks in the underlying relationship using a multiple structural breaks test. The results indicate significant parameter instability and suggest that, despite the advances in economic and financial integration, real interest rate parity has not fully recovered from a breakdown in the 1980s.
Multinational Firms and Labor Market Pooling
Authors: Larch Mario , Lechthaler Wolfgang 
Published: October 2015

AbstractIn the presence of increasing specialization of workers it becomes more and more difficult for firms to find the most suitable workers. In such an environment a multinational enterprise (MNE) has an advantage because it can exchange workers between plants in different countries. Recruiting from the home and foreign plant leads to a larger labor market pool for an MNE, reducing the mismatch of its workforce. This paper analyzes the consequences of this advantage for production, employment, prices and wages. In line with recent empirical results, we find that the additional ability to recruit workers from the home and foreign labor market leads to lower mismatch, higher average productivity of workers, lower prices, higher output, and higher employment of a plant of an MNE as compared with a national firm, while the wage‐effects depend on firm productivity.
The Common Component in Forward Premiums: Evidence from the Asia–Pacific Region
Authors: Nagayasu Jun 
Published: October 2015

AbstractWe empirically analyze the behavior of the forward premium. Unlike previous research, we use data from Asia–Pacific countries and adopt a panel data approach that allows us to decompose the forward premium into common and idiosyncratic components. Our data suggest the presence of one common factor and the stationarity of both components for short maturities, leading to the conclusion of a stationary forward premium. In contrast, the stationarity of the premium is less supported by the longer maturity data. Furthermore, a large portion of the premium fluctuation is shown to be due to a common factor, particularly over the short time horizon, which in turn can be explained by economic developments in the USA.
Do Immigrants Affect Firm‐Specific Wages?*
Authors: Malchow‐Møller Nikolaj , Munch Jakob R. , Skaksen Jan Rose 
Published: October 2015

AbstractWe propose and test a novel effect of immigration on wages. Existing studies have focused on the wage effects that result from changes in the aggregate labour supply in a competitive labour market. We argue that if labour markets are not fully competitive, immigrants might also affect wage formation at the most disaggregate level – the workplace. Using linked employer−employee data, we find that an increased use of low‐skilled immigrant workers has a significantly negative effect on the wages of native workers at the workplace – also when controlling for potential endogeneity of the immigrant share using both fixed effects and instrumental variables.
Let Us Pray: Classroom Worship in Theological Education
Authors: Laytham Brent 
Published: October 2015

AbstractTheological education typically includes classroom worship, a practice of great pedagogical power and curricular import. As pedagogy, classroom worship does four things. It focuses teaching and learning on God, and fosters theological dispositions necessary for sustaining that attention. Second, it rightly positions the entire class in dialogical relation to the divine Thou, in communal relation to each other, the larger church and the wider world, and in personal relations that risk transformation. Third, it frames theological education as an integrative practice of faith and learning. Finally, it invites teachers to know their students as whole persons and students to trust their teachers as spiritual guides. As curriculum, classroom worship may have greater significance than chapel worship for many students and at particular schools. It should be moved from implicit curriculum to explicit, with careful attention to the null curriculum and to the matrices of relationship within which worship has meaning.
Teaching the Bible and Film: Pedagogical Promises, Pitfalls, and Proposals
Authors: Rindge Matthew S. , Runions Erin , Ascough Richard S. 
Published: October 2015

AbstractThis article begins by recognizing the increasing use of film in Religion, Theology, and Bible courses. It contends that in many Biblical Studies (and Religious Studies and Theology) courses, students are neither taught how to view films properly, nor how to place films into constructive dialogue with biblical texts. The article argues for a specific pedagogical approach to the use of film in which students learn how to view a film closely, in its entirety, on its own terms, and in its own voice. Viewing a film in this manner by attending to its aesthetic integrity is a prerequisite for constructing a fruitful dialogue between films and biblical texts. The essay concludes with three specific examples of what this approach might look like. Two responses follow the essay; Erin Runions of Pomona College considers two additional learning goals we might consider, and Richard Ascough of Queens University at Kingston helpfully distinguishes a range of possible pedagogical goals for introducing film into the Biblical Studies classroom.
Entry into Export Markets and Product Quality
Authors: Álvarez Roberto , Fuentes J. Rodrigo 
Published: October 2015

AbstractUsing a rich data set of Chilean exporters, we analyse several issues regarding the relationship between entry into export markets and product quality. We find that every year, a large number of new exporting relationships are initiated, but the survival rate of these entries is very low and declines over time. Using unit values as a proxy for product quality, our estimations show that entry is generally associated with higher product quality. This higher quality, however, tends to reduce over time and eventually disappears three years after entry. In addition, our evidence suggests that the positive relationship between entry and quality is more prevalent in new exporters. To better identify this effect, we explore whether there are systematic differences across sectors. As expected, for sectors in which quality differentiation may be important, our findings reveal that reference‐price and differentiated products show a higher price in the year of entry and a longer convergence to incumbent prices. These results hold after controlling for potential sample selection bias.