bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geranylgeraniol supplementation leads to an improvement in inflammatory parameters and reversal of the disease specific protein signature in patients with hyper-IgD syndrome
Authors: Sediva Anna , Orlicky Martin , Vrabcova Petra , Klocperk Adam , Kalina Tomas , Fujiwara Hideji , Hsu Fong-Fu , Bambouskova Monika 
Published: July 2024

AbstractMevalonate kinase (MVK) deficiency, a rare autosomal recessive disease, significantly impacts metabolism and immunity, leading to mevalonic aciduria in severe cases and hyper-IgD syndrome (HIDS) in partial deficiency. These conditions arise due to disruptions in the mevalonate pathway, which is essential metabolic pathway responsible for the synthesis of non-sterol isoprenoids and other molecules. The resulting metabolic blockade triggers autoinflammatory responses, primarily due to deficient isoprenoid intermediates such as geranylgeranyl pyrophosphate (GGPP). This first reported pilot study evaluates the safety and efficacy of dietary geranylgeraniol supplementation (GG) in three patients with HIDS. Over three months, GG supplementation showed no liver toxicity and did not alter lipid profiles. Although GG did not rise the plasma levels of GGPP, the plasma proteomics showed significant changes induced by GG. Proteomic analysis further revealed that GG supplementation can reverse some of the features of HIDS-specific plasma protein signature, highlighting its potential to modulate inflammation and protein prenylation pathways. These findings suggest that GG supplementation could be a promising metabolic intervention to mitigate inflammation in HIDS, warranting further, more targeted investigation in larger clinical trials.
Baseline characteristics among 101,407 people with myocardial infarction over nine-year time period: a population-based study using primary care data
Authors: Arsene Corneliu T 
Published: July 2024

AbstractCardioVascular (CV) Disease (CVD) accounts for 25% of all UK deaths [1-4]. Before developing and applying new or existing CV risk prediction tools [5-22] for prediction of incident CVD events, it is important to have a description of the baseline characteristics of the patients who experienced a myocardial Infarction (MI) event. This paper presents the baseline characteristics of a cohort of patients who experienced a first MI between 1st of January 2006 and 31st of December 2014 in England, UK, age equal or greater than 35 years
AD plasma biomarkers are stable for an extended period at –20°C: implications for resource-constrained environments
Authors: Ayele Biniyam A. , Whitehead Patrice L. , Pascual Julianna , Gu Tianjie , Arvizu Jamie , Golightly Charles G. , Adams Larry D. , Pericak-Vance Margaret A. , Vance Jeffery M. , Griswold Anthony J. 
Published: July 2024

ABSTRACTStandard procedures for measuring Alzheimer’s disease (AD) plasma biomarkers include storage at -80°C. This is challenging in countries lacking research infrastructure, such -80°C freezer. To investigate stability of AD biomarkers from plasma stored at -20°C, we compared aliquots stored at -80°C and others at -20°C for two, four, six, fifteen, and thirty-five weeks. pTau181, Aβ42, Aβ40, NfL, and GFAP were measured for each timepoint. pTau181 and Aβ42/Aβ40 ratios showed minimal variation for up to 15 weeks. NfL and GFAP had higher variability. This finding of 15-week stability at -20°C enables greater participation in AD biomarker studies in resource constrained environments.
Stroke rates, risk factors, and aspirin prescribing trends in the Canadian Fabry Disease Initiative cohort
Authors: Théberge Emilie T. , Selvage Caroline , Thomas Anita , LeMoine Kaye M. , Robichaud Rebecca , Zhou Lily , Yeung Darwin F. , West Michael L. ,   the CFDI investigators group, Sirrs Sandra , Lehman Anna 
Published: July 2024

AbstractBackgroundFabry disease (FD) is an X-linked disorder caused by deleterious variants inGLA.Cardiovascular disease (CVD) causes premature mortality in FD. Hope for aspirin (acetylsalicylic acid, ASA) to reduce CVD risks in FD as primary prevention may have been tempered by the 2018 ARRIVE, ASCEND, and ASPREE clinical trials. It is unclear how new ASA guidance applies to FD patients, who have a high rate of young-onset, small vessel stroke compared with the general population.MethodsLongitudinal data spanning 2007-2023 from patients in the Canadian Fabry Disease Initiative (CFDI) were analyzed retrospectively. Incident stroke and transient ischemic attack (TIA), other CVD events, FD-specific risk factors, and ASA/antiplatelet (“ASA/AP”) prescription before and after 2018 were compared between groups who never had an event (“primary prevention group”) to those who had incident stroke/TIA during the study. Stroke/TIA rates were compared between the sexes, byGLAvariant severity, and between the CFDI to Canadian statistics. 10-year atherosclerotic CVD (ASCVD) risk was calculated using the 2013 ACC/AHA risk calculator. ASA/AP prescription rate was compared before and after 2018.ResultsOut of 641 patients, 57 had an incident stroke/TIA during the study, and 193 with complete data remained in the primary prevention group. Stroke/TIA rates were significantly higher among male patients (0.026/year) than females (0.0098/year), and higher among patients with severeGLAvariants (males: 0.031, females: 0.0096) compared to those with attenuated variants (males: 0.011, females: 0.0088). No patients under 60 years at their incident stroke/TIA had high (≥10%) calculated 10-year ASCVD risk. Fewer patients were prescribed ASA/AP for primary prevention after 2018.ConclusionsThere was a high incidence of stroke/TIA in the younger CFDI cohort compared to the general Canadian population, despite low levels of traditional vascular risk factors as represented in 10-year estimated ASCVD risk. Primary prevention use of ASA has declined.
Identifying Artifacts from Large Library Docking
Authors: Wu Yujin , Liu Fangyu , Glenn Isabella , Fonseca-Valencia Karla , Paris Lu , Xiong Yuyue , Jerome Steven V. , Brooks Charles L. , Shoichet Brian K. 
Published: July 2024

AbstractWhile large library docking has discovered potent ligands for multiple targets, as the libraries have grown, the very top of the hit-lists can become populated with artifacts that cheat our scoring functions. Though these cheating molecules are rare, they become ever-more dominant with library growth. Here, we investigate rescoring top-ranked molecules from docking screens with orthogonal methods to identify these artifacts, exploring implicit solvent models and absolute binding free energy perturbation (AB-FEP) as cross-filters. In retrospective studies, this approach deprioritized high-ranking non-binders for nine targets while leaving true ligands relatively unaffected. We tested the method prospectively against results from large library docking AmpC β-lactamase. From the very top of the docking hit lists, we prioritized 128 molecules for synthesis and experimental testing, a mixture of 39 molecules that rescoring flagged as likely cheaters and another 89 that were plausible true actives. None of the 39 predicted cheating compounds inhibited AmpC up to 200µM in enzyme assays, while 57% of the 89 plausible true actives did do so, with 19 of them inhibiting the enzyme with apparent Kivalues better than 50µM. As our libraries continue to grow, a strategy of catching docking artifacts by rescoring with orthogonal methods may find wide use in the field.Graphical TOC Entry
Evidence-based XAI of clinical decision support systems for differential diagnosis: Design, implementation, and evaluation
Authors: Miyachi Yasuhiko , Ishii Osamu , Torigoe Keijiro 
Published: July 2024

AbstractIntroductionWe propose the Explainable AI (XAI) model for Clinical Decision Support Systems (CDSSs). It supports physician’s Differential Diagnosis (DDx) with Evidence-based Medicine (EBM). It identifies instances of the case data contributing to predicted diseases. Each case data is linked to the sourced medical literature. Therefore, this model can provide medical professionals with evidence of predicted diseases.MethodsThe source of the case data (training data) is medical literature. The prediction model (the main model) uses Neural Network (NN) + Learning To Rank (LTR). Physicians’ DDx and machines’ LTR are remarkably similar. The XAI model (the surrogate model) uses k-Nearest Neighbors Surrogate model (k-NN Surrogate model). The k-NN Surrogate model is a symphony of Example-based explanations, Local surrogate model, and k-Nearest Neighbors (k-NN). Requirements of the XAI for CDSS and features of the XAI model are remarkably adaptable. To improve the surrogate model’s performance, it performs “Selecting its data closest to the main model.” We evaluated the prediction and XAI performance of the models.ResultsWith the effect of “Selecting,” the surrogate model’s prediction and XAI performances are higher than those of the “standalone” surrogate model.ConclusionsThe k-NN Surrogate model is a useful XAI model for CDSS. For CDSSs with similar aims and features, the k-NN Surrogate model is helpful and easy to implement. The k-NN Surrogate model is an Evidence-based XAI for CDSSs.Unlike current commercial Large Language Models (LLMs), Our CDSS shows evidence of predicted diseases to medical professionals.
The adoption and implementation of local government planning regulations to manage hot food takeaways near schools in England: A qualitative process evaluation
Authors: Hassan S , Thompson C , Adams J , Chang M , Derbyshire D , Keeble M , Liu B , Mytton OT , Rahilly J , Savory B , Smith R , White M , Burgoine T , Cummins S 
Published: July 2024

AbstractIntroductionAccess to hot food takeaways, particularly near schools, is of growing concern for policymakers seeking to reduce childhood obesity globally. In England, United Kingdom (UK), local government jurisdictions are implementing planning policies to reduce access by restricting or denying planning permission for new takeaway outlets near schools. We used a qualitative approach to explore local government officers’ perspectives on the barriers to and facilitators of the adoption, implementation, and perceived effectiveness of these policies.MethodsIn 2021-2022, we conducted semi-structured interviews with 29 local planning (‘planners’) and public health government officers from 15 different local authorities across England who adopted a policy to restrict new takeaways. Data were analysed thematically.ResultsParticipants explained that they mostly thought the policies facilitated the refusal of applications for new takeaways near schools. However, participants speculated that businesses identified alternative opportunities to operate including functioning as ‘restaurants’ or within other locations. Effective working relationships between planners and public health officers were important for adoption and implementation, although planning and public health agendas did not always align and there were tensions between economic development and health improvement goals. The policy was adapted to suit local needs and priorities; in some cases, the policy was not used in areas where economic growth was prioritised. Clarity in policy wording and establishing a formal process for implementing policies including a designated individual responsible for checking and reviewing takeaway applications helped ensure consistency and confidence in policy implementation.ConclusionAlthough sometimes challenging, the policies were commonly described as feasible to implement. However, they may not completely prevent new takeaways opening, particularly where takeaways are relied upon to enhance local economies or where takeaway businesses find alternative ways to operate. Nevertheless, the policies can serve to shift the balance of power that currently favours commercial interests over public health priorities.HighlightsPlanning and public health officers struggled to align economic and health agendasPolicy champions helped align agendas and push takeaway management policies forwardPolicies were adapted to avoid use where they negatively impacted economic growthEstablished processes and clearly worded policies facilitated policy implementationThe polices made it easier to deny planning permission for new takeaways
DASH diet, Reduced Rank Regression Dietary Patterns and relations with kidney function in the CHRIS general population study
Authors: Barbieri Giulia , Garcia-Larsen Vanessa , Lundin Rebecca , Fujii Ryosuke , Ferraro Pietro Manuel , Gambaro Giovanni , Melotti Roberto , Gögele Martin , Cazzoletti Lucia , Pramstaller Peter P , Zanolin Maria Elisabetta , Pattaro Cristian , Hantikainen Essi 
Published: July 2024

AbstractObjectiveWe assessed dietary patterns (DPs) using the pre-defined Dietary Approaches to Stop Hypertension (DASH) score and reduced rank regression (RRR) to evaluate their association with estimated glomerular filtration rate (eGFR) in a general population sample.MethodsWe analysed cross-sectional data from 6,133 healthy adult participants of the Cooperative Health Research In South Tyrol (CHRIS) study. Using self-reported food frequency questionnaire data, we derived the DASH-score and two RRR-based sex-specific DP-scores based on nine cardio-renal-metabolic parameters. We fitted sex-stratified linear and non-linear models to assess associations with creatininebased eGFR.ResultsMales with higher intake of cereals, whole grains, sugar, fruits, and legumes, and lower intake of beer, and red and processed meat (MDP1), exhibited higher eGFR levels. Coherently, high adherence to the DASH-style diet was associated with higher eGFR. In females, the associations varied by menstrual status. Among those with ceased menstruation, a low intake of meat, spirits, refined grains, beer, and fish, and a high intake of whole grains and dairy products was associated with higher eGFR. In females still experiencing regular menstruation, a high intake of beef, nuts, beer, legumes, fish, and coffee, and low intake of refined grains, (FDP2) was associated with lower eGFR. No association was observed with the DASH score in females.ConclusionOur findings confirm the DASH-style diet is associated with better kidney function in males, but not in females. By identifying sex-specific kidney function-oriented DPs, the RRR approach provides new insights into the diet-eGFR relation, highlighting in addition potential effect modification by menstrual status.
Optimizing telework in an epidemic context: contrasting the infectious and non-communicable diseases perspectives
Authors: Moutet Leo , Leclerc Quentin , Layan Maylis , Ait Bouziad Karim , Dab William , Henriot Paul , Hodbert Elise , Louati Narimene , Maurin Aurelie , thonon Frederique , Znaty Sylvie , Benhalima Mohamed , Jean Kevin , Temime Laura 
Published: July 2024

1.AbstractObjectivesIn a global context of increasing telework, this study explores its health effects, to determine if there is an optimal teleworking frequency during an epidemic. We aim to quantify the relationship between teleworking frequency and both infectious disease (ID) transmission and non-communicable disease (NCD) risk.MethodsWe developed a mathematical model simulating ID transmission and NCD acquisition in a medium-sized company, analysing how different teleworking levels impact workers health. We conducted a rapid literature review to identify potential exposure-response relationships between teleworking and NCD risk and inform this model. We then simulated infection dynamics over a three-month epidemic wave to contrast ID and NCD risks in relation to the extent of telework engagement.ResultsEvidence from the literature showed varying patterns of NCD risk across different teleworking frequencies. Depending on these relationships, we observed that risk may peak at low, intermediate, or high teleworking levels. We demonstrated the existence of a benefit-risk balance between reducing ID transmission and potentially increasing NCD burden.ConclusionsOur study highlights that the definition of an “optimal” teleworking frequency to maximise health benefits is inconsistent, and depends on the NCD considered. Effective teleworking strategies must consider both ID prevention and the risk of NCDs, and weigh these health impacts accordingly to optimise societal health outcomes.
Apathy under the surface: Theorizing quiet quitting’s impact on organizational learning
Authors: Srivastava Ayushi , Pandey Agrata , Sharma Dheeraj , Ghosh Koustab 
Published: July 2024

Purpose
This paper integrates research on quiet quitting (a mindset where employees restrict their efforts to their job description) and organizational learning (OL) to illustrate how quiet quitting challenges the sub-processes of OL.

Design/methodology/approach
By integrating the existing literature on quiet quitting and OL, this paper identifies and maps the challenges of quiet quitting to the sub-processes of OL, namely, intuiting, interpreting, integrating, and institutionalizing within the 4I framework of Crossan et al. (1999).

Findings
This paper conceptually establishes that quiet quitting undermines employees’ cognitive efforts and weakens employees’ contribution to team discussions. Further, quiet quitting undermines suggestion sharing and creates a reluctance to share knowledge, undermining OL.

Practical implications
The paper provides actionable strategies for managers to tackle the challenges of quiet quitting on OL.

Originality/value
To the best of the authors' knowledge, this study is amongst the first to illustrate the challenges of quiet quitting on OL.
Purchase intent in social media for healthcare services: the influence of value co-creation, brand equity and engagement
Authors: de Assis Walter Macêdo , Vilela Bruno 
Published: July 2024

Purpose
This study aims to analyze the effect of social media marketing (SMM), generated by doctors and dentists, on consumers’ purchase intention, via the influence of the value co-creation perception, brand equity and consumer brand engagement. Additionally, this study analyzes the moderating role of purchase frequency.

Design/methodology/approach
A sample of 110 respondents was surveyed using a self-administered questionnaire. The partial least squares structural equation modeling (PLS-SEM) was used to test the research hypothesis.

Findings
The findings reveal that SMM positively influences value co-creation perception. Value co-creation perception positively influences brand equity and consumer brand engagement. Brand equity positively influences purchase intention. The moderating role of frequency was confirmed. However, the effects of consumer brand engagement on purchase intention were not confirmed.

Practical implications
The study findings enable healthcare marketers to develop social media marketing and branding strategies to engage consumers and increase perceived value, brand equity and purchase intention of healthcare services.

Originality/value
To the best of the authors’ knowledge, this study is the first to introduce SMM as an antecedent of the relationship between value co-creation and brand equity. This study is also the first to test the relationship between value co-creation and brand equity in the healthcare sector. A new integrated model was proposed to understand the effects of SMM on the intention to purchase healthcare services.
Handicrafts as cultural creative clusters: a spatial-cultural planning approach for the regeneration of the urban historical fabrics
Authors: Taheri Shima , Khalilpour Farnaz , Ashayeri Mehdi , Shabani Amirhosein 
Published: July 2024

Purpose
The purpose of this paper is to evaluate the role of handicraft production units within creative cultural clusters (CCCs) and their impact on urban regeneration, particularly within the historical fabric of Isfahan. It aims to identify the key factors contributing to the development of CCCs and how these clusters, in turn, influence tourism development.

Design/methodology/approach
The research method of this study is based on a quantitative approach, using a researcher-devised questionnaire as the primary data collection instrument. The statistical population included 227 units of handicraft makers in the historical fabric of Isfahan. The data processing and analysis were performed using SPSS software.

Findings
Statistical analysis confirms the creative industries, spatial and socio-cultural indices significantly impact tourism, with means of 14.19, 19.07 and 15.11. Clustering, cultural resources and tourism are key to CCCs growth, while innovation and cultural identity have less effect. CCCs enhance Isfahan’s historical fabric, improving urban space attractiveness and fostering social ties. Handicraft clusters around Naqsh-e Jahan square notably influence the economy and cultural identity, with shop placement reflecting the city’s character.

Originality/value
The originality of this research lies in its analysis of how handicraft production within CCCs contributes to urban regeneration and tourism in Isfahan, with a novel focus on the socio-cultural and economic impacts of these clusters in a historical context.
Work ethic, cultural impact and perceived performance – innovative insights from three countries
Authors: Runić-Ristić Marija , Savić Tot Tijana , Ljepava Nikolina , Tot Vilmoš 
Published: July 2024

Purpose
This study aims to examine the relationship between work ethics and organizational performance and investigate the influence of respondents’ career stages on their work ethic among British, United Arab Emirates (UAE) and Serbian nations.

Design/methodology/approach
This research is based on a survey of British, UAE and Serbian managers, whose task was to assess the dimensions of the multidimensional work ethic profile (MWEP) and organizational performance. Since the MWEP does not analyze work ethics in the context of religion, it is deemed the most suitable instrument for this study because it analyzes work ethics among the three cultures that practice different religions.

Findings
The results revealed that national culture impacts work ethics. British managers place greater value on the wasted time, self-reliance and morality dimensions of work ethics. Serbian managers prefer the leisure and delay of gratification dimensions, while UAE managers value hard work ethics more than the other two groups of managers. The study also shows that respondents’ career stage influences their work ethic, and a significant relationship exists between different dimensions of work ethics and organizational performance in all three nations.

Originality/value
This study contributes to the theory by analyzing work ethic and its relationship with organizational performance and respondents’ career stages in three nations that share business interests. It addresses a research gap by comparing work ethics in developed, developing and a country in socio-economic transition.