bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical predictors of effective continuous positive airway pressure in patients with obstructive sleep apnea/hypopnea syndrome
Authors: Lai Chi‐Chih , Friedman Michael , Lin Hsin‐Ching , Wang Pa‐Chun , Hwang Michelle S. , Hsu Cheng‐Ming , Lin Meng‐Chih , Chin Chien‐Hung 
Published: January 2015

Objectives/HypothesisTo identify standard clinical parameters that may predict the optimal level of continuous positive airway pressure (CPAP) in adult patients with obstructive sleep apnea/hypopnea syndrome (OSAHS).Study DesignThis is a retrospective study in a tertiary academic medical center that included 129 adult patients (117 males and 12 females) with OSAHS confirmed by diagnostic polysomnography (PSG).MethodsAll OSAHS patients underwent successful full‐night manual titration to determine the optimal CPAP pressure level for OSAHS treatment. The PSG parameters and completed physical examination, including body mass index, tonsil size grading, modified Mallampati grade (also known as updated Friedman's tongue position [uFTP]), uvular length, neck circumference, waist circumference, hip circumference, thyroid‐mental distance, and hyoid‐mental distance (HMD) were recorded.ResultsWhen the physical examination variables and OSAHS disease were correlated singly with the optimal CPAP pressure, we found that uFTP, HMD, and apnea/hypopnea index (AHI) were reliable predictors of CPAP pressures (P = .013, P = .002, and P < .001, respectively, by multiple regression). When all important factors were considered in a stepwise multiple linear regression analysis, a significant correlation with optimal CPAP pressure was formulated by factoring the uFTP, HMD, and AHI (optimal CPAP pressure = 1.01 uFTP + 0.74 HMD + 0.059 AHI − 1.603).ConclusionsThis study distinguished the correlation between uFTP, HMD, and AHI with the optimal CPAP pressure. The structure of the upper airway (especially tongue base obstruction) and disease severity may predict the effective level of CPAP pressure.Level of Evidence4. Laryngoscope, 125:1983–1987, 2015
Synthesis of Main‐Chain Metal Carbonyl Organometallic Macromolecules (MCMCOMs)
Authors: Cao Kai , Murshid Nimer , Wang Xiaosong 
Published: January 2015

Synthesis of main‐chain metal carbonyl organometallic macromolecules (MCMCOMs) is difficult, mainly due to the instability of metal carbonyl complexes. Despite its challenge a number of MCMCOMs has been prepared by strategically using organometallic, organic, and polymer synthetic chemistry. Main contributions to this research field were reported by the groups of Tyler, Pannell, and Wang and are briefly summarized in this article.
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Food Reciprocity and Sustainability in Early Childhood Care and Education in Aotearoa New Zealand
Authors: Ritchie Jenny 
Published: January 2015

AbstractThis article offers a perspective from early childhood care and education in Aotearoa New Zealand. It draws from the data of four recent studies to demonstrate pedagogical practices informed by Indigenous (Māori) perspectives. Māori values, such asmanaakitanga(caring, hospitality, generosity) andwhanaungatanga(relatedness), are shown featuring in routines focused on provision of food and serving as a key focus of early childhood education for sustainability. It is argued that providing opportunities for children to become engaged with growing, cooking and sharing food enables them to operationalise compassion towards themselves, others and the environment, reconnecting with the source of their food and demonstrating generosity and care to others (both human and more-than-human) in their communities. This can be viewed as a pedagogical response to the increasing encroachment of neoliberalism, with its incumbent individualism and lack of collectivist consciousness or concern for the environment, into education settings. Furthermore, drawing upon Indigenous perspectives honours traditional, localised wisdom regarding sustainability practices.
Multi-scale habitat use analysis and interspecific Ecology of the Critically Endangered Black-breasted Puffleg Eriocnemis nigrivestis
Authors: GUEVARA ESTEBAN A. , BONACCORSO ELISA , DUIVENVOORDEN JOOST F. 
Published: January 2015

SummaryThe Black-breasted Puffleg Eriocnemis nigrivestis is a hummingbird endemic to Ecuador and considered Critically Endangered, given its limited distribution, low population numbers, and ongoing habitat degradation. We investigated habitat use patterns using landscape and microhabitat variables. In addition, we explored a previously postulated competition hypothesis involving the Black-breasted Puffleg and the Gorgeted Sunangel Heliangelus strophianus. Our results suggest that landscape variables may play a role in the habitat selection process; specifically the distance to nearest forest border seems to have a significant effect on our habitat model. We speculate that, as the species is known to perform seasonal movements, the avoidance of forest border might reduce the physiological stress caused by altitudinal migration. At microhabitat level, Black-breasted Puffleg seems not sensitive to forest structure variables. Our findings suggest that ensuring forest tract connectivity, between the altitudinal extremes of the species’ range at the north-western flanks of the Pichincha volcano, might be crucial for survival of the species during its annual cycle. However, non-metric multidimensional scaling (NMDS) indicates that Black-breasted Puffleg and the Gorgeted Sunangel do not overlap spatially, but this finding is not conclusive considering our field observations.
Conduct, rules and the origins of institutions
Authors: SMITH VERNON L. 
Published: January 2015

Abstract:This paper supports the effort by Hindriks and Guala (2014) to integrate the prevailing accounts of institutions. I illustrate with traffic narratives how we can think of their concept of rules-in-equilibrium as evolving from universal elementary forms. These conceptions resonate fully with Smith (1759) who saw rule-following conduct as the basis of human sociality and action.
Recoverable plasticity in penta-twinned metallic nanowires governed by dislocation nucleation and retraction
Authors: Qin Qingquan , Yin Sheng , Cheng Guangming , Li Xiaoyan , Chang Tzu-Hsuan , Richter Gunther , Zhu Yong , Gao Huajian 
Published: January 2015

AbstractThere has been relatively little study on time-dependent mechanical properties of nanowires, in spite of their importance for the design, fabrication and operation of nanoscale devices. Here we report a dislocation-mediated, time-dependent and fully reversible plastic behaviour in penta-twinned silver nanowires. In situ tensile experiments inside scanning and transmission electron microscopes show that penta-twinned silver nanowires undergo stress relaxation on loading and complete plastic strain recovery on unloading, while the same experiments on single-crystalline silver nanowires do not exhibit such a behaviour. Molecular dynamics simulations reveal that the observed behaviour in penta-twinned nanowires originates from the surface nucleation, propagation and retraction of partial dislocations. More specifically, vacancies reduce dislocation nucleation barrier, facilitating stress relaxation, while the twin boundaries and their intrinsic stress field promote retraction of partial dislocations, resulting in full strain recovery.
Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease
Authors: Proitsi P , Kim M , Whiley L , Pritchard M , Leung R , Soininen H , Kloszewska I , Mecocci P , Tsolaki M , Vellas B , Sham P , Lovestone S , Powell J F , Dobson R J B , Legido-Quigley C 
Published: January 2015

AbstractThere is an urgent need for the identification of Alzheimer’s disease (AD) biomarkers. Studies have now suggested the promising use of associations with blood metabolites as functional intermediate phenotypes in biomedical and pharmaceutical research. The aim of this study was to use lipidomics to identify a battery of plasma metabolite molecules that could predict AD patients from controls. We performed a comprehensive untargeted lipidomic analysis, using ultra-performance liquid chromatography/mass spectrometry on plasma samples from 35 AD patients, 40 elderly controls and 48 individuals with mild cognitive impairment (MCI) and used multivariate analysis methods to identify metabolites associated with AD status. A combination of 10 metabolites could discriminate AD patients from controls with 79.2% accuracy (81.8% sensitivity, 76.9% specificity and an area under curve of 0.792) in a novel test set. Six of the metabolites were identified as long chain cholesteryl esters (ChEs) and were reduced in AD (ChE 32:0, odds ratio (OR)=0.237, 95% confidence interval (CI)=0.10–0.48, P=4.19E−04; ChE 34:0, OR=0.152, 95% CI=0.05–0.37, P=2.90E−04; ChE 34:6, OR=0.126, 95% CI=0.03–0.35, P=5.40E−04; ChE 32:4, OR=0.056, 95% CI=0.01–0.24, P=6.56E−04 and ChE 33:6, OR=0.205, 95% CI=0.06–0.50, P=2.21E−03, per (log2) metabolite unit). The levels of these metabolites followed the trend control>MCI>AD. We, additionally, found no association between cholesterol, the precursor of ChE and AD. This study identified new ChE molecules, involved in cholesterol metabolism, implicated in AD, which may help identify new therapeutic targets; although, these findings need to be replicated in larger well-phenotyped cohorts.
PASPA: a web server for mRNA poly(A) site predictions in plants and algae
Authors: Ji Guoli , Li Lei , Li Qingshun Q. , Wu Xiangdong , Fu Jingyi , Chen Gong , Wu Xiaohui 
Published: January 2015

Abstract
Motivation: Polyadenylation is an essential process during eukaryotic gene expression. Prediction of poly(A) sites helps to define the 3′ end of genes, which is important for gene annotation and elucidating gene regulation mechanisms. However, due to limited knowledge of poly(A) signals, it is still challenging to predict poly(A) sites in plants and algae. PASPA is a web server for poly(A) site prediction in plants and algae, which integrates many in-house tools as add-ons to facilitate poly(A) site prediction, visualization and mining. This server can predict poly(A) sites for ten species, including seven previously poly(A) signal non-characterized species, with sensitivity and specificity in a range between 0.80 and 0.95.
Availability and implementation: http://bmi.xmu.edu.cn/paspa
Contact: xhuister@xmu.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
The knowledge of Italian wines on export markets
Authors: Barisan Luigino , Boatto Vasco , Rossetto Luca , Salmaso Luigi 
Published: January 2015

Purpose
– The European Union (EU) has strongly rearranged the management of EU wine policy by introducing actions for promoting wine in third countries. The purpose of this paper is to evaluate factors affecting the knowledge of Italian wines in foreign consumers, i.e., to what extend wine promotion actions can improve the consumer’s awareness or the reputation of Italian wines. As a consequence, these activities may increase the wine consumption as well as wine exports in emerging markets.

Design/methodology/approach
– Data have been collected through survey questionnaires where information about wine tasting, sensory satisfaction and preferences about Italian wines have been collected. The sample survey collects preferences of wine market operators in both EU and third countries. The survey, carried out from 2009 to 2011, includes 3,579 interviews classified according to four promotion actions: press conference, wine tasting, tasting course, knowledge of Italian wines. Data have been analyzed through a nonparametric combination (NPC) of dependent permutation tests to evaluate differences between and within country groups and to assess the consumer perception about Italian wines through the Keller’s model.

Findings
– So far, Italian wine promotion activities, supported by EU wine policy, are fragmented among in many small and sometimes low effective actions. Research results may be helpful in designing more effective promotional strategies on third countries. In particular, promotional activities which should be focussed on consumer’s appreciation of Italian wines as a brand instead of promoting specific wines or wineries.

Research limitations/implications
– The NPC method is a nonparametric tool which does not measure the structure of consumer’s preferences, i.e, it does give any measure of relationships among consumer’s utility and factors affecting it as it happens when a modeling approach is applied.

Practical implications
– Targeted promotion and information actions strongly focussed internal and external wine attributes can increase the level of knowledge in foreign consumers. It can make more efficient the marketing activity oriented to the export market.

Originality/value
– The NPC method offers an innovative, flexible and well-tested approach for the analysis of multivariate hypothesis when we are dealing with complex problems in wine market.
Legislation, standards and diagnostics as a backbone of food safety assurance in Serbia
Authors: Smigic Nada , Rajkovic Andreja , Djekic Ilija , Tomic Nikola 
Published: January 2015

Purpose
– The purpose of this paper is to analyze the current situation of multidimensional food safety assurance in Serbia, as an official candidate for European Union (EU) membership, in relation to its EU food law harmonization efforts.

Design/methodology/approach
– Serbian assurance scheme was covered in this paper included food safety legislation, control and standards.

Findings
– The food safety system in Serbia needs improvements in the area of effectiveness and efficiency of food safety control and inspection services, knowledge and expertise of state inspectors, governmental officials, food safety consultants and auditors. Additionally, problems related to the overlapping responsibilities of various legal authorities and inspection services have to be solved, with an improved transparency and communication between legal authorities, customers, consumers and food business operators.

Originality/value
– An overview of current situation in food safety assurance in Serbia is shown.
Critical success factors examined in ISO 9001:2008-certified Greek companies using multidimensional statistics
Authors: Ismyrlis Vasileios , Moschidis Odysseas , Tsiotras George 
Published: January 2015

Purpose
– The purpose of this paper is to examine the level of the importance and implementation of the critical success factors (CSFs) required for the appropriate function of a quality management system (QMS) in ISO 9001:2008-certified companies and the differences between the CSFs and the demographic variables of the companies.

Design/methodology/approach
– A research project was carried out in Greek companies from all business sectors using the questionnaire technique. The selected companies all implement a QMS in accordance with the ISO 9001:2008 standard. Correspondence analysis, a methodology from the multidimensional statistics field, was also used to identify significant differences between the importance and implementation levels of the CSFs of the QMS.

Findings
– The importance that quality assurance managers attribute to these CSFs was high enough in most categories, but there was a significant difference in the implementation level, which displayed much lower scores. The most important factors seem to be management commitment, education, and communication, while the least important were the availability of data and use of statistics. Differences between categories of demographic variables were present only for the firm size variable.

Research limitations/implications
– The study was based on the perception (i.e. subjective data) of only one quality manager/representative of each company.

Practical implications
– The paper provides information to certified companies in Greece on the differences in the importance and implementation levels of quality management practices (especially for hard factors) and motivation to investigate possible causes. Moreover, the most important factors for the successful implementation of ISO 9001 are presented.

Originality/value
– This paper describes the implementation and given importance of the CSFs in companies with experience of the ISO 9001:2008 standard and for the analysis of the data a methodology from the multidimensional field is applied, with the complementary use of some special tables of coincidences.
Autonomous evolution of service system in cluster supply chain
Authors: Xue Xiao , Wang Shufang , Chao Hao 
Published: January 2015

Purpose
– The purpose of this paper is to provide strong theoretical and technical support for the dynamic evolution of service system in “Cluster Supply Chain”(CSC), which can deal with two kinds of context changes: the internal service component changes and the external customer requirement changes.

Design/methodology/approach
– A “feedback-based” evolution mechanism of service system for CSC is proposed in this study. By means of the feedback update of enterprise service’s Quality of Service (QoS) attribute and the adjustment of the assumed QoS evaluation model, the evolution of service system can be achieved to suit the dynamic market demands.

Findings
– Results of the study suggest: by means of the “feed-back” evolution mechanism of service system, the enterprises in CSC can handle the context changes effectively to maintain the optimized operation status.

Practical implications
– The implementation of evolution mechanism in service system can keep the effectiveness of enterprise service composition to face the frequent service component changes and the unpredictable market turbulence.

Originality/value
– This paper proposes a method to realize the autonomous evolution of service system in CSC, which can support the flexibility and adaptability of enterprise service composition in the changing environment.
Fuzzy trust evaluation based on consistency intensity for cloud services
Authors: Huo Ying , Zhuang Yi , Ni Siru 
Published: January 2015

Purpose
– The purpose of this paper is to define an evaluation model for cloud services to deal with the fuzzy information and propose a novel fuzzy evaluation method based on consistency intensity to analyze the quantitative value from the fuzzy information.

Design/methodology/approach
– The cloud service evaluation framework is constructed, and different trusted indicators for the infrastructure services and the application services are designed, respectively. In the novel fuzzy evaluation method, the interval values can be aggregated by the Dempster-Shafer Theory and be transformed into the certain value by linguistic discount factor. The consistency intensity is proposed to determine the value of the linguistic discount factor, which can reflect the mainstream opinions in the assessment.

Findings
– The proposed method can solve the problem on the analysis and synthesis of the fuzzy evaluation information. An instance of trust evaluation of cloud storage service is illustrated to verify that the proposed method can express the opinions of all evaluators more adequately.

Practical implications
– A serial of experiments are carried out on NetLogo, and the results show that the proposed method is practical and efficient.

Originality/value
– Instead of obtaining only the qualitative results by the multi-attribute decision-making method, the fuzzy evaluation method based on consistency intensity can obtain the quantitative results from the fuzzy information according to linguistic discount factor and consistency intensity.
Latent class analysis of need descriptors within an Irish youth mental health early intervention program toward a typology of need
Authors: Peiper Nicholas , Illback Robert J. , O'Reilly Aileen , Clayton Richard 
Published: January 2015

AbstractAimSignificant overlap and comorbidity has been demonstrated among young people with mental health problems. This paper examined demographic characteristics, heterogeneity of need descriptors and services provided among young people (12–25 years) engaging in brief interventions at Jigsaw in the Republic of Ireland.MethodBetween 1 January 2013 and 31 December 2013, a total of 2571 young people sought help from 1 of 10 Jigsaw sites. Of these, 1247 engaged in goal‐focused brief interventions, typically consisting of one to six face‐to‐face sessions. Descriptive statistics were used to summarize social and demographic factors. Latent class analysis was used to cluster young people into relevant typologies of presenting issues. Multinomial logistic regression was then performed to determine significant predictors of class membership.ResultsThe most common age of young people was 16. More women (59.6%) than men engaged in brief interventions, 56% attended school, 74% lived with their family of origin or with one parent, and 54.2% came from families where parents were married. Using established fit criteria, four relevant typologies emerged: Developmental (26.8%), Comorbid (15.8%), Anxious (42.7%) and Externalising (14.6%). Predictors varied by class membership, but general family problems and lack of adult support emerged as the strongest predictors for all classes.ConclusionThis study demonstrated that the mental health needs of young people in Ireland are significant and diverse. Because Jigsaw favours a more descriptive approach to problem identification, the four typologies suggest a need to determine program capacity in engaging youth with heterogeneous presenting issues and to tailor brief interventions to each group's clinical profiles.
Natalizumab analogon therapy is effective in a B cell‐dependent multiple sclerosis model
Authors: Häusler Darius , Nessler Stefan , Kruse Niels , Brück Wolfgang , Metz Imke 
Published: January 2015

AimsNatalizumab is a humanized monoclonal antibody specific for CD49d receptors of integrins. It inhibits the entry of inflammatory cells into the central nervous system and is approved for the treatment of relapsing‐remitting multiple sclerosis (MS). Several lines of evidence indicate an involvement of B cells and plasma cells in MS pathogenesis. However, treatment with the natalizumab analogon PS/2 immunoglobulin G (IgG) has so far only been investigated in T cell‐mediated animal models of MS. Due to the importance of B lineage cells in the pathogenesis of MS, the objective of the present study has thus been to analyse the effects of PS/2 IgG in a mouse model of MS with T and B cell cooperation (OSE mice).MethodsOSE mice were treated with the natalizumab analogon PS/2 IgG either at disease onset or after peak of disease. Treatment was also performed with PS/2 F(ab′)2 fragments.ResultsPS/2 IgG treatment improved the clinical outcome and decreased spinal cord demyelination and immune cell infiltration if given early in the disease course. Treatment increased blood leukocytes and resulted in a partial internalization of CD49d in T and B cells. The therapeutic effects of PS/2 IgG injections were independent of the Fc fragment as F(ab′)2 injections were equally beneficial. In contrast, PS/2 IgG was not effective when given late in the disease course.ConclusionsResults indicate that natalizumab may also be beneficial in MS with B cell‐driven immunopathogenesis.