bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pertumbuhan dan Hasil Kedelai Edamame (Glycine max (L) Merill) Terhadap Pemberian Kombinasi Legin dan Kompos di Media Tailing Pasir Pasca Tambang Timah
Authors: Dila Ardila Mughniyarti , Rion Apriyadi  , Riwan Kusmiadi  
Published: July 2024

Post tin mining land in Bangka Belitung can still be utilized as agricultural land with the application of various soil amandment including the combination of compost and legin. The compost provide organic matter for the soil and legin provide rhizobium to maximize nitrogen fixation in the soil. Post tin mining land improved with compost and legin combination can be used potentially for the development of edamame soybean commodities which are widely known as adaptive plant on suboptimal land. The purpose of this study was to determine the type of compost, legin dose and the best combination of both compost and legin on the growth and the yield of edamame soybeans in sand tailing media. This research had been conducted in February-August 2023 at the Experimental and Research Station, Faculty of Agriculture, Fisheries and Marine, Universitas Bangka Belitung. This study used a field experimental method with a Factorial Randomized Group Design with the first factor was the dose of legin, consists of 3 treatment levels, namely: L0: No treatment (Control), L1: 10 g legin, L2: 12 g legin. The second factor was the type of compost consisting of 3 treatment levels, namely: P1: Cow dung compost, P2: rice husk compost, P3: Commercial compost. There were 9 treatment combinations that were replicated 4 times. Each experimental unit had 6 plants so that 216 plant populations were obtained and 144 plants were obtained as samples. The results showed that the dose of 12 g legin had the highest effect on edamame growth and 10 g legin treatment had the highest effect on edamame yield. Commercial compost treatment had the best effect to edamame growth, while rice husk compost had the best effect to edamame yield. The combination of rice husk compost and 10 g legin was the treatment combination that showed the best growth and yield of edamame soybean plants in sand tailing media of post tin mining.
Keywords: Edamame, rice husk, compost, legin, sand tailings
A Look at Smallholder Cattle Farming in Payakumbuh, West Sumatra
Authors: Reswati  , Putra Aronal Arief 
Published: July 2024

The existence of smallholder cattle farming in Payakumbuh was studied. The research was conducted to obtain profiles of farmer demographics, cattle farming management, and reproductive performance. A survey was conducted in five sub-districts in Payakumbuh by interviewing 50 cattle farmers and conducting direct field observation. Smallholder farmers in Payakumbuh are typically an average of 45.02 years old, commonly senior high school graduates, occupied in the agricultural field with their own cattle ownership, experienced for 18.1 years, involved in cattle farming for additional income, and commonly focused on Simental crossbred raising. Cattle management was mainly categorized as good, as represented by feeding management (application of routine forage and concentrate, twice daily feeding frequency, and ad libitum drinking water), rearing (intensive rearing and natural weaning), housing (permanent housing structures, individual housing systems, and draw well water sources), and health (regular deworming). Reproductive performance (20.4 months age at first mating, 1.55 service per conception, 14.63-month calving interval, and 3.96 months for re-mating after calving) is also close to the ideal standard. To sum up, the presence of smallholder farmers is significant and could serve as a reference for farmers in other areas of West Sumatra. Enhancing applied technology is necessary to upgrade their cattle farming scale.
On Ekeland Variational Principle and Its Applications Through Fuzzy Quasi Metric Spaces with Non-Archimedean t-norm
Authors: Dutta Riya , Nayak Prasun Kumar , De Sujit Kumar 
Published: July 2024

The aim of this article is to introduce Ekeland variational principle (EVP) and some results in fuzzy quasi metric space (FQMS) under the non-Archimedean \(t\)-norms. In this article the basic topological properties and a partial order relation are defined on FQMS. Utilizing Brézis-Browder principle on a partial order set, we extend the EVP to FQMS also. Moreover, we derive Takahashi’s minimization theorem, which ensures the existence of a solution of an optimal problem without taking the help of compactness and convexity properties on the underlying space. Furthermore, we give an equivalence chain between these two theorems. Finally, two fixed point results namely the Banach fixed point and the Caristi-Kirk fixed point theorems are described extensively.
ДОСЛІДЖЕННЯ ЗАГРОЗ ІНФОРМАЦІЙНОЇ БЕЗПЕКИ ТА СПОСОБІВ ЇХ ВИРІШЕННЯ В КОМП'ЮТЕРНИХ МЕРЕЖАХ НА КАНАЛЬНОМУ РІВНІ
Authors: Polotai O. I. , Fedynets N. I. , Kukharska N. P. 
Published: July 2024

Постановка проблеми. Інформаційна безпека комп'ютерних мереж – це процес захисту комп'ютерних мереж від несанкціонованого доступу, зловживань, витоку конфіденційної інформації та інших загроз, що виникають через зловмисників або недбалість користувачів. Для захисту комп'ютерних мереж використовуються різні технології та методи, включаючи захист паролем, шифрування даних, мережеві брандмауери, системи виявлення вторгнень, антивірусне програмне забезпечення та аутентифікацію користувачів.Метою статті є дослідження основних атак на комп’ютерні мережі, які зловмисник реалізовує, використовуючи слабкі місця другого (канального) рівня моделі OSI та способів нейтралізації цих атак за допомогою програмних інструментів мережевого обладнання компанії Cisco.Результати. У статті детально описано суть канального рівня моделі OSI, який є другим рівнем. Описано характеристики цього рівня та показано, які основні функції він виконує. Проаналізовано основні загрози інформаційної безпеки комп’ютерних мереж, а також атаки на мережі, які зловмисник реалізовує, використовуючи усі «вузькі місця» канального рівня моделі OSI. Детально описано кожну з таких загроз і способи її реалізації. Також в статті детально описано основні способи захисту інформації комп’ютерної мережі на канальному рівні моделі OSI від атак. Наводяться детальні теоретичні кроки для реалізації блокування, нейтралізації або пом’якшення атак на мережі, які зловмисник здійснює на канальному рівні моделі OSI. У статті детально описані способи нейтралізації цих атак за допомогою програмних інструментів мережевого обладнання компанії Cisco.Висновки. Безпека комп'ютерних мереж є важливим аспектом захисту важливої інформації та конфіденційних даних, а також забезпечення нормальної роботи комп'ютерних систем і мереж. Рівень безпеки комп'ютерних мереж варіюється від організації до організації та від компанії до компанії, але завжди важливо вживати найкращих можливих заходів для захисту критично важливої інформації та забезпечення стабільності системи.
Estrés laboral en docentes ecuatorianos: Factores, síntomas y estrategias de mitigación
Authors: Herrera Soria Ruth Guadalupe , Trávez Osorio Gladys Mercedes , Cangui Basantes Sonia Verónica , Jiménez Zambrano Braulio Antonio 
Published: July 2024

Introducción: El estrés laboral es un problema significativo que afecta negativamente la salud y el desempeño profesional de los docentes, quienes son especialmente vulnerables debido a sus numerosas responsabilidades. Metodología: Este estudio, basado en un análisis bibliográfico previo, utiliza dos encuestas exhaustivas para investigar tanto los factores y síntomas del estrés laboral como las estrategias de mitigación empleadas por docentes con amplia experiencia. Desarrollo: Los datos, analizados mediante métodos estadísticos avanzados con IBM SPSS, revelan patrones significativos y ofrecen una comprensión profunda del fenómeno. Resultados: Los resultados, interpretados en el contexto educativo ecuatoriano, buscan contribuir a la formulación de políticas que mejoren la salud y el bienestar de los docentes, promoviendo un entorno laboral más saludable y productivo. Conclusiones: Las áreas críticas de estrés laboral para los docentes son la sobrecarga de trabajo, las condiciones del aula y la relación con los padres de familia. Los resultados muestran que los docentes frecuentemente experimentan estrés en estas áreas, aunque con variaciones significativas entre individuos. Las estrategias para mitigar el estrés incluyen apoyo emocional, ejercicio físico regular y mejoras en la comunicación y políticas administrativas dentro de la institución. Área de estudio general: Educación, Área de estudio específica: Estrés laboral.
Pembibitan Pohon Kelompok Petani Hutan di Desa Tobololo
Authors: Riyadin Aisjah , Tamrin Mahdi , Baguna Firlawanti Lestari , Tamnge Fadila , Ashari Reyna 
Published: July 2024

Kelompok tani hutan merupakan kelompok yang sangat penting dalam sistem penjagaan hutan dan konservasi. Petani hutan menjadi garis depan untuk memelihara hutan yang telah ada ataupun merehabilitasi hutan yang sudah rusak, serta merawat, mengelola dan meningkatkan penghasilan dari hutan. Kelompok tani hutan (KTH) dalam bentuk Lembaga Pengelola Hutan Desa (LPHD) Qahabanga Kelurahan Tobololo Ternate mengembangkan pembibitan pohon sebagai salah satu kegiatan dalam pengelolaan Hutan Desa Tobololo. Pengabdian ini bertujuan untuk mempelajari permasalahan dan menganalisis aspek-aspek penting yang dapat menjadi pembelajaran dari kegiatan pembibitan yang dilakukan. Kegiatan pengabdian dilaksanakan dengan mengobservasi dan mewawancarai kelompok tani pada LPHD Qahabanga serta melakukan analisis secara deskriptif permasalahan yang terjadi dan merumuskan saran untuk pengembangan pembibitan. LPHD Qahabanga memiliki pembibitan pohon masih sangat rentan dengan kondisi lokal, terutama aktivitasnya yang masih bergantung dengan pembinaan dan bantuan dana dari pemerintah, terbatasnya anggota yang aktif menjadikan kelompok ini masih cukup sulit untuk berkembang. Peran penting dari pendamping lapangan masih sangat dibutuhkan, terutama dalam menyiasati proses menghasilkan benih bermutu dan bernilai komersial untuk digunakan dalam program penghijauan dan konservasi hutan.
Kata Kunci : bibit bermutu, konservasi, Kelurahan Tobololo, LPHD
Integrated analysis of gut microbiome and its metabolites in ACE2-knockout and ACE2-overexpressed mice
Authors: Song Lini , Ji Wenyi , Cao Xi 
Published: July 2024

BackgroundAberrant activation of the classic renin–angiotensin system (RAS) and intestinal micro dysbiosis adversely affect insulin resistance (IR), dyslipidemia, and other metabolic syndrome markers. However, the action of angiotensin-converting enzyme 2 (ACE2) and gut health in systemic homeostasis vary, and their interaction is not completely understood.MethodsWe adopted a combinatory approach of metabolomics and fecal 16S rRNA analysis to investigate gut microbiota and metabolite in two different mouse models, ACE2 knockout (ACE2 KO) mice and the ACE2-overexpressing obese mice.Results16S rRNA gene sequencing revealed that ACE2 influences microbial community composition and function, and ACE2 KO mice had increased Deferribacteres, Alcaligenaceae, Parasutterella, Catenibacterium, and Anaerotruncus, with decreased short-chain fatty acid (SCFA)-producing bacteria (Marvinbryantia and Alistipes). In contrast, ACE2-overexpressed mice exhibited increased anti-inflammatory probiotic (Oscillospiraceae, Marinifilaceae, and Bifidobacteriaceae) and SCFA-producing microbes (Rikenellaceae, Muribaculaceae, Ruminococcaceae, Odoribacter, and Alistipes) and decreased Firmicutes/Bacteroidetes, Lactobacillaceae, Erysipelotrichaceae, and Lachnospiraceae. Metabolome analysis indicated differential metabolites in ACE2 KO and ACE2-overexpression mice, especially the glucolipid metabolism-related compounds. Furthermore, correlation analysis between gut microbiota and metabolites showed a dynamic mutual influence affecting host health.ConclusionOur study confirms for the first time a significant association between ACE2 status and gut microbiome and metabolome profiles, providing a novel mechanism for the positive effect of ACE2 on energy homeostasis.
The risk of ovarian cancer in hormone replacement therapy users: a systematic review and meta-analysis
Authors: Xiang Hongqin , Wang Liangying , Sun Liping , Xu Song 
Published: July 2024

BackgroundWith the increasing use of hormone replacement therapy (HRT), there is a need to understand its impact on the occurrence of female malignant tumors. This systematic review and meta-analysis aimed to assess the risk of ovarian cancer associated with HRT and its related risk factors.MethodsPUBMED, OVID, Embase, Cochrane, and Web of Science were searched from 1980 to April 2022 to identify studies on the risk of ovarian cancer and hormone replacement therapy. The random-effects model was used to estimate the pooled risk of HRT in ovarian cancer, both in cohort studies and case-control studies. Additionally, the analysis examined the outcomes associated with different types of estrogen plus progesterone regimens. Meta-regression and sensitive analysis were performed to evaluate the heterogeneity.Results21 cohort studies (involving 15,313 cases and 4,564,785 participants) and 30 case-control studies (including 18,738 cases and 57,747 controls) were analyzed. The pooled risks of ovarian cancer for HRT users were 1.20 (95% confidence interval [CI] 1.01–1.44) from cohort studies and 1.13 (95%CI 1.04–1.22) from case-control studies. However, after restricting the study period to recent decades, the significant results indicating a higher risk disappeared in cohort studies conducted after 2010 and in case-control studies conducted after 2006. Furthermore, the continuous use of estrogen-progesterone replacement therapy (EPRT) was associated with a risk comparable to that of sequential use. Subgroup analysis showed that both estrogen replacement treatment (ERT) and EPRT had minor risks; The risk further increased with prolonged exposure time, particularly for durations exceeding 10 years. Additionally, serous ovarian cancer appeared to be more susceptible than other pathological types.ConclusionThe risk of ovarian cancer associated with HRT has been decreasing over time. However, ERT may increase this risk, particularly when used for an extended period. It is recommended that long-time users consider continuous EPRT as a safer alternative.Systematic review registrationwww.crd.york.ac.uk/prospero/, identifier CRD42022321279.
Integrative single-cell analysis of longitudinal t(8;21) AML reveals heterogeneous immune cell infiltration and prognostic signatures
Authors: Li Xue-Ping , Song Jiang-Tao , Dai Yu-Ting , Zhang Wei-Na , Zhao Bai-Tian , Mao Jia-Ying , Gao Yan , Jiang Lu , Liang Yang 
Published: July 2024

IntroductionImmunotherapies targeting T cells in solid cancers are revolutionizing clinical treatment. Novel immunotherapies have had extremely limited benefit for acute myeloid leukemia (AML). Here, we characterized the immune microenvironment of t(8;21) AML patients to determine how immune cell infiltration status influenced prognosis.MethodsThrough multi-omics studies of primary and longitudinal t(8;21) AML samples, we characterized the heterogeneous immune cell infiltration in the tumor microenvironment and their immune checkpoint gene expression. Further external cohorts were also included in this research.ResultsCD8+ T cells were enriched and HAVCR2 and TIGIT were upregulated in the CD34+CD117dim%-High group; these features are known to be associated with immune exhaustion. Data integration analysis of single-cell dynamics revealed that a subset of T cells (cluster_2) (highly expressing GZMB, NKG7, PRF1 and GNLY) evolved and expanded markedly in the drug-resistant stage after relapse. External cohort analysis confirmed that the cluster_2 T-cell signature could be utilized to stratify patients by overall survival outcome.DiscussionIn conclusion, we discovered a distinct T-cell signature by scRNA-seq that was correlated with disease progression and drug resistance. Our research provides a novel system for classifying patients based on their immune microenvironment.
Adenomatous hyperplasia induced by chronic cherry pit retention mimicking an endobronchial tumor-case series and systematic review of literature
Authors: Oruqaj Gani , Krombach Gabriele , Gattenloehner Stefan , Herold Susanne , Vadász István , Seeger Werner , Tello Khodr , Hecker Matthias 
Published: July 2024

IntroductionEndobronchial foreign body aspiration is not common in adults, but it is a life-threatening event. Recurrent pneumonias by chronic retention of foreign body often lead to initial medical presentation of the patient. However, lymphoplasmacellular bronchitis with adenomatous hyperplasia and squamous epithelium metaplasia with complete or partial blockage of lobar bronchus mimicking lung tumor is rare in literature, and this particular condition is often misdiagnosed.Case presentationwe report our experience in the diagnostic and management of two elderly patients with recurrent pneumonia, admitted in hospital for further examination. In both patients, with no history of aspiration, the cherry pit was detected during bronchoscopy and recanalization with flexible cryoprobe, surrounded by purulent secretion, occluding completely the right upper lobe in the first case, and partially the left lower lobe associated with persistent actinomycosis in the second case, with signs of local inflammation, bronchial adenomatous hyperplasia mimicking lung tumor at initial bronchoscopic examination. Histology showed a lymphoplasmacellullar bronchitis with adenomatous hyperplasia and squamous epithelium metaplasia because of chronic retention of foreign body.ConclusionBronchoscopy examination should be considered in cases where there is an unresolved chronic cough with recurrent pneumonia or persistent actinomycosis in patients with high risk. Cryoprobe is a safe and feasible approach for treatment of airway obstructions due to chronic foreign body retention. Furthermore, relevant findings are discussed here, along with a review of the pathologic alterations and treatment modalities seen in chronic retention of foreign body and airway injury.
Stress-induced anxiety-related behavior in mice is driven by enhanced excitability of ventral tegmental area GABA neurons
Authors: Mitten Eric H. , Souders Anna , Marron Fernandez de Velasco Ezequiel , Wickman Kevin 
Published: July 2024

IntroductionStress and trauma are significant risk factors for many neuropsychiatric disorders and diseases, including anxiety disorders. Stress-induced anxiety symptoms have been attributed to enhanced excitability in circuits controlling fear, anxiety, and aversion. A growing body of evidence has implicated GABAergic neurons of the ventral tegmental area (VTA) in aversion processing and affective behavior.MethodsWe used an unpredictable footshock (uFS) model, together with electrophysiological and behavioral approaches, to investigate the role of VTA GABA neurons in anxiety-related behavior in mice.ResultsOne day after a single uFS session, C57BL/6J mice exhibited elevated anxiety-related behavior and VTA GABA neuron excitability. The enhanced excitability of VTA GABA neurons was correlated with increased glutamatergic input and a reduction in postsynaptic signaling mediated via GABAA and GABAB receptors. Chemogenetic activation of VTA GABA neurons was sufficient to increase anxiety-related behavior in stress-naïve mice. In addition, chemogenetic inhibition of VTA GABA neurons suppressed anxiety-related behavior in mice exposed to uFS.DiscussionThese data show that VTA GABA neurons are an early substrate for stress-induced anxiety-related behavior in mice and suggest that approaches mitigating enhanced excitability of VTA GABA neurons may hold promise for the treatment of anxiety provoked by stress and trauma.
Aberrant functional connectivity in anterior cingulate gyrus subregions in migraine without aura patients
Authors: Cheng Jinming , Li Yan , Chen Keyang , Cao Yungang , Liu Kun , Zhang Xi , Wu Xiaoyuan , Wang Zhihong , Liu Xiaozheng , Li Litao 
Published: July 2024

BackgroundThe anterior cingulate gyrus (ACG) is an important regulatory region for pain-related information. However, the ACG is composed of subregions with different functions. The mechanisms underlying the brain networks of different subregions of the ACG in patients with migraine without aura (MwoA) are currently unclear.MethodsIn the current study, resting-state functional magnetic resonance imaging (rsfMRI) and functional connectivity (FC) were used to investigate the functional characteristics of ACG subregions in MwoA patients. The study included 17 healthy volunteers and 28 MwoA patients. The FC calculation was based on rsfMRI data from a 3 T MRI scanner. The brain networks of the ACG subregions were compared using a general linear model to see if there were any differences between the two groups. Spearman correlation analysis was used to examine the correlation between FC values in abnormal brain regions and clinical variables.ResultsCompared with healthy subjects, MwoA patients showed decreased FC between left subgenual ACG and left middle cingulate gyrus and right middle temporal gyrus. Meanwhile, MwoA patients also showed increased FC between pregenual ACG and right angular gyrus and increased FC between right pregenual ACG and right superior occipital gyrus. The FC values between pregenual ACG and right superior occipital gyrus were significantly positively correlated with the visual analogue scale.ConclusionDisturbances of FC between ACG subregions and default model network and visual cortex may play a key role in neuropathological features, perception and affection of MwoA. The current study provides further insights into the complex scenario of MwoA mechanisms.