bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of a Specialized Hernia Center and Standardized Practices on Surgical Outcomes in Hernia Surgery: A Systematic Review and Meta-Analysis
Authors: da Silveira Carlos Andre Balthazar , Rasador Ana Caroline Dias , Lima Diego L. , Nogueira Raquel , Sanha Valberto , Kasakewitch João P. G. , Cavazzola Leandro T. , Sreeramoju Prashanth , Malcher Flavio 
Published: July 2024

Aim: Hernia registries report that guidelines are not always implemented by general surgeons and suggest that the success rate of this procedure is higher in hernia specialty centers. There are many definitions of hernia centers, but their objectives consist of improving healthcare by homogenizing the clinical practice. We performed a systematic review and meta-analysis to analyze hernia centers’ definitions and compare hernia centers with non-specialized centers.Material and Methods: Cochrane Central, Scopus, Scielo, and PubMed were systematically searched for studies defining a hernia center or comparing hernia centers and non-specialized centers. Outcomes assessed were recurrence, surgical site events, hospital length of stay (LOS), and operative time. We performed subgroup analyses of hernia type. Statistical analysis was performed with R Studio.Results: 3,260 studies were screened and 88 were thoroughly reviewed. Thirteen studies were included. Five studies defined a hernia center and eight studies, comprising 141,366 patients, compared a hernia center with a non-specialized center. Generally, the definitions were similar in decision-making and educational requirements but differed in structural aspects and the steps required for the certification. We found lower recurrence rates for hernia centers for both inguinal (1.08% versus 5.11%; RR 0.21; 95% CI 0.19 to 0.23; p &lt; 0.001) and ventral hernia (3.2% vs. 8.9%; RR 0.425; 95% CI 0.28 to 0.64; p &lt; 0.001). Hernia centers also presented lower surgical site infection for both ventral (4.3% vs. 11.9%; RR 0.435; 95% CI 0.21 to 0.90; p = 0.026) and inguinal (0.1% vs. 0.52%; RR 0.15; 95% CI 0.02 to 0.99; p = 0.49) repair.Conclusion: Our systematic review and meta-analysis support that a hernia center establishment improves postoperative outcomes data.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024522263, PROSPERO CRD42024522263.
The SElf-Care After REnal Transplantation Study: A Retrospective Evaluation of a Home-Monitoring Program Implemented as Standard Care
Authors: Hezer B. , Reinders M. E. J. , van den Hoogen M. W. F. , Tielen M. , van de Wetering J. , Hesselink D. A. , Massey E. K. 
Published: July 2024

After transplantation self-management is essential for graft survival and optimal quality of life. To address the need for home-based support in self-management, we implemented the “SelfCare after Renal Transplantation” (SeCReT) box, containing home-monitoring equipment combined with a smartphone application that was linked to the electronic patient records. This study investigated the uptake and continuation, protocol adherence, and subjective evaluation of this home-monitoring program. All “de novo” kidney recipients who received the SeCReT-box in the study period (Aug 2021–Dec 2022) were eligible for inclusion. Protocol adherence was defined as ≥75%. Subjective evaluation was assessed with a 5-item questionnaire. Of the 297 recipients transplanted, 178 participants (60%) were included in the analysis. Protocol adherence was 83%, 73%, 66%, and 57% respectively at 5, 10, 20, and 40 weeks of the protocol. With regard to continuation, 135 participants were still in the program at the end of the study period (75% retention rate). Regarding subjective evaluations, 82% evaluated the program positively, and 52% reported lower care needs due to home-monitoring. Results are positive among those who entered and continued the program. Qualitative research is needed on barriers to entering the program and facilitators of use in order to promote optimal implementation.
Superior Anticancer and Antifungal Activities of New Sulfanyl-Substituted Niclosamide Derivatives
Authors: Ma Jingyi , Veeragoni Dileepkumar , Ghosh Hindole , Mutter Nicole , Barbosa Gisele , Webster Lauren , Schobert Rainer , Sande Wendy van de , Dandawate Prasad , Biersack Bernhard 
Published: July 2024

The approved anthelmintic salicylanilide drug niclosamide has shown promising anticancer and antimicrobial activities. In this study, new niclosamide derivatives with trifluoromethyl, trifluoromethylsulfanyl, and pentafluorosulfanyl substituents replacing the nitro group of niclosamide were prepared (including the ethanolamine salts of two promising salicylanilides) and tested for their anticancer activities against esophageal adenocarcinoma (EAC) cells. In addition, antifungal activity against a panel of Madurella mycetomatis strains, the most abundant causative agent of the neglected tropical disease eumycetoma, was evaluated. The new compounds revealed higher activities against EAC and fungal cells than the parent compound niclosamide. The ethanolamine salt 3a was the most active compound against EAC cells (IC50 = 0.8–1.0 µM), and its anticancer effects were mediated by the downregulation of anti-apoptotic proteins (BCL2 and MCL1) and by decreasing levels of β-catenin and the phosphorylation of STAT3. The plausibility of binding to the latter factors was confirmed by molecular docking. The compounds 2a and 2b showed high in vitro antifungal activity against M. mycetomatis (IC50 = 0.2–0.3 µM) and were not toxic to Galleria mellonella larvae. Slight improvements in the survival rate of G. mellonella larvae infected with M. mycetomatis were observed. Thus, salicylanilides such as 2a and 3a can become new anticancer and antifungal drugs.
Urine Ammonium Concentrations and Cardiovascular and Kidney Outcomes in Systolic Blood Pressure Intervention Trial Participants with CKD
Authors: Bullen Alexander L. , Katz Ronit , Seegmiller Jesse , Garimella Pranav S. , Ascher Simon B. , Rifkin Dena E. , Raphael Kalani L. , Shlipak Michael G. , Ix Joachim H. 
Published: July 2024

Key Points

Among nondiabetic individuals with hypertension and CKD, higher urine ammonium concentration is associated with higher risk of cardiovascular disease.Urine ammonium was not associated with all-cause mortality or CKD progression, AKI, or linear eGFR decline in the Systolic Blood Pressure Intervention Trial cohort.

Background
Impaired urine ammonium excretion is common in CKD and may identify risk of metabolic acidosis earlier than reductions in serum bicarbonate or pH and thus may have associations with cardiovascular disease (CVD) outcomes. We evaluated the association of urine ammonium with CVD and kidney outcomes among persons with hypertension and nondiabetic CKD enrolled in a trial of BP reduction.

Methods
We measured urine ammonium concentration in spot urine specimens collected at baseline among 2092 participants of the Systolic Blood Pressure Intervention Trial (SPRINT) with an eGFR <60 ml/min per 1.73 m2. We used multivariable-adjusted Cox models to evaluate associations of urine ammonium concentration with the SPRINT CVD composite outcome (myocardial infarction, acute coronary syndrome, stroke, heart failure, or CVD death), all-cause mortality, the SPRINT kidney composite outcome (50% kidney function decline, ESKD, or transplant), and AKI.

Results
At baseline, the mean (SD) age was 73 (9) years; 40% were female; and 25% were Black participants. The mean (SD) serum bicarbonate was 25.6 (2.8) mmol/L, median (interquartile range) urine ammonium concentration was 14.4 (9.5–23.1) mmol/L, and median (interquartile range) eGFR was 49 (39–55) ml/min per 1.73 m2. There were 255 CVD composite events, 143 deaths, 63 kidney composite events, and 146 AKI events during a median follow-up of 3.8 years. In multivariable models, each two-fold higher urinary ammonium concentration was associated with a 26% (95% confidence interval, 1.05 to 1.52) higher risk of the CVD composite, whereas there was no association with all-cause mortality, the SPRINT kidney composite outcome, or AKI.

Conclusions
Among nondiabetic individuals with hypertension and CKD, higher urine ammonium concentration is associated with higher risk of CVD. Further studies are needed to evaluate this association in other cohorts.
Pruritus Severity and Serum Phosphate in CKD: A Post Hoc Analysis of Difelikefalin Studies
Authors: Fishbane Steven N. , Block Geoff A. , Evenepoel Pieter , Budden Jeffrey , Morin Isabelle , Menzaghi Frédérique , Wen Warren , Lerma Edgar V. 
Published: July 2024

Key Points

No correlation was observed between pruritus severity and serum phosphate or response to placebo or difelikefalin in patients with CKD-associated pruritus undergoing hemodialysis.Difelikefalin improved itch versus placebo irrespective of baseline serum phosphate.

Background
CKD-associated pruritus (CKD-aP) has historically been associated with elevated serum phosphate (sP). Difelikefalin is a novel antipruritic agent approved for the treatment of moderate-to-severe CKD-aP in adults undergoing hemodialysis. This post hoc analysis used data from phase 3 difelikefalin studies (KALM-1, KALM-2, and open-label Study 3105) to assess the role of sP in the pathogenesis of CKD-aP and whether difelikefalin ameliorates CKD-aP in patients with and without elevated sP.

Methods
Patients with moderate-to-severe CKD-aP undergoing hemodialysis with baseline sP data were included in the analysis (KALM-1 and KALM-2, n=845; Study 3105, n=220). Assessments included correlation between 24-hour Worst Itching Intensity Numerical Rating Scale (WI-NRS) score and sP.

Results
In KALM-1 and KALM-2, baseline characteristics in the overall population were similar between patients with sP ≤5.5 and >5.5 mg/dl; no significant correlation was observed between WI-NRS and sP at baseline or in week 12. In patients receiving placebo, no correlation was observed between WI-NRS and sP at baseline or between their change from baseline to week 12 (all P < 0.05). Clinically meaningful (≥3-point) reductions from baseline to week 12 in WI-NRS scores were reported by more patients receiving placebo with baseline sP ≤5.5 mg/dl than >5.5 mg/dl (least squares mean 37.2% versus 27.4%; odds ratio [95% confidence interval], 0.63 [0.41 to 0.97]; P = 0.04). A greater proportion of patients treated with difelikefalin achieved a ≥3-point WI-NRS reduction from baseline to week 12 versus placebo and was similar between sP ≤5.5 and >5.5 mg/dl subgroups (least squares means 51.1% versus 57.6% [P = 0.20]). No significant relationships between sP and WI-NRS in patients receiving difelikefalin were identified in Study 3105 at any time point.

Conclusions
No correlation was observed between pruritus severity and sP or response to placebo or difelikefalin in patients with CKD-aP undergoing hemodialysis. Difelikefalin improved itch versus placebo irrespective of baseline sP.
Experience in the Treatment of Non-Scarring Alopecia Areata Using a Biomedical Cell Product Based on Autologous Follicular Stem Cells
Authors: Музыченко А.П. , Сикирицкая В.В. , Квачева З.Б. , Василевич И.Б. , Кумова И.В. , Качук М.В. , Павлович Н.А. , Надейко А.П. 
Published: July 2024

Введение. Алопеция является распространенным диагнозом в клинической практике. Наиболее частым ее видом является нерубцовая потеря волос, в большинстве случаев – андрогенная или телогеновая алопеция. Стволовые клетки фолликулярного происхождения благодаря своим пролиферативным свойствам лежат в основе регенеративного клеточного лечения выпадения волос. Цель. Изучение эффективности лечения нерубцовых алопеций с применением биомедицинского клеточного продукта на основе аутологичных фолликулярных стволовых клеток. Материалы и методы. Под динамическим наблюдением находился 21 пациент с верифицированным диагнозом андрогенной и телогеновой алопеции. Для оценки терапевтической эффективности апробируемого метода лечения были использованы трихоскопические критерии и дерматологический индекс качества жизни. Результаты. При оценке клинической эффективности проведенного лечения у 57% пациентов было достигнуто улучшение, что подтверждалось положительной динамикой показателей фототрихограмм. Таким образом, представленные данные свидетельствуют о терапевтической эффективности аутологичных фолликулярных стволовых клеток в лечении нерубцовых алопеций.
Introduction. Alopecia is a common diagnosis in clinical practice. The most prevalent type of alopecia is non-scarring alopecia, with the majority of cases being androgenetic alopecia or telogen effluvium. Because of its proliferative capabilities, follicle-derived stem cells lie at the heart of regenerative cellular treatment for hair restoration. Purpose. To evaluate the efficacy of treatment of non-scarring alopecia using a biomedical cell product based on autologous follicular stem cells. Materials and methods. This prospective study included 21 patients with androgenic alopecia and alopecia effluvium. Trichoscopic criteria and dermatological quality of life index were used to evaluate the therapeutic efficacy of the approbabled treatment. Results. Improvement was achieved in 57% of patients after treatment, which was confirmed by phototrichograms. Thus, the presented data indicate the therapeutic efficacy of autologous follicular stem cells in the non- scarring alopecia treatment.
To the Question of Diagnostic Criteria and Pathogenetic Features of Netherton’s Syndrome
Authors: Заславский Д.В. , Горланов И.А. , Таганов А.В. , Дроздова Л.Н. , Большакова Е.С. , Манылова Е.С. , Бондарь О.И. , Кучеренко Е.В. , Козлова Д.В. 
Published: July 2024

Линеарный огибающий ихтиоз Комеля – крайне редкое изолированное заболевание кожи, проявляющееся серпигинозными и мигрирующими эритематозными бляшками с ободком шелушения по периферии. Триада, включающая ихтиоз (у большинства – линеарный огибающий ихтиоз), изменения волос по типу Trichrrhexis invaginata и атопию, характеризует синдром Нетертона. На сегодняшний день нет сообщений об успешном лечении данного заболевания. Только благодаря современным возможностям медицинской генетики и лабораторной диагностики удалось установить патогенетические особенности заболевания, которые обусловлены мутацией гена SPINK5. Наличие мутации приводит к формированию дисфункции кожного барьера у пациентов, в результате чего при проникновении экзогенных антигенов в кожу формируется неспецифическое воспаление и активируется воспалительный ответ по Th2-пути. В мировой научной литературе опубликованы немногочисленные данные о лечении пациентов с заболеваниями из группы врожденных ихтиозов с применением дупилумаба. Полученные данные позволяют провести аналогию с патофизиологическими процессами при атопическом дерматите, в лечении которого наиболее эффективным сегодня является ингибитор IL-4, 13. Авторы наблюдали хороший клинический ответ у пациентов с заболеваниями из группы врожденных ихтиозов. Приводим описание успешного лечения пациента с линеарным огибающим ихтиозом Комеля в составе синдрома Нетертона с помощью ингибитора IL-4, 13 в педиатрической дерматологической практике.
Linear circumflex ichthyosis of Comel is an extremely rare isolated skin disease that manifests as serpiginous and migrating erythematous patches with double-edged scales. The triad of ichthyosis (often – linear circumflex ichthyosis), Trichorrhexis invaginata and atopy characterize Netherton syndrome. There are no reports of successful treatment of this disease. Due to the possibilities of medical genetics and laboratory diagnostics, it was possible to establish the pathogenetic features of the disease, which are caused by the mutation of the SPINK5 gene. This mutation leads to skin barrier dysfunction in patients, as a result exogenous antigens penetrate the skin, form there nonspecific inflammation and the activates inflammatory response mediated by Th2 pathway. Few data have been published in the world scientific literature about the treatment of patients with diseases from the group of congenital ichthyosis using dupilumab. Obtained data allow us to draw an analogy with the pathophysiological processes in atopic dermatitis, in the treatment of which the IL-4, 13 inhibitor is the most effective today. The authors observed a good clinical response in patients with diseases from the group of congenital ichthyosis. We describe the successful treatment of a patient with linear circumflex ichthyosis as a part of Netherton syndrome with an IL-4, 13 inhibitor in pediatric dermatological practice.
THE CONCEPT AND PROSPECTS OF CRYPTOCURRENCIES
Authors: МАХНЕНКО С.И. , СИМОНОВ А.А. 
Published: July 2024

В статье рассматривается место криптовалютных рынков в мировой экономике. Определены ключевые риски активного внедрения достижений IT в финансовом секторе. Показано, что криптовалюты связаны с расчетными операциями, инвестиционной деятельностью и спекуляциями на валютных рынках. Утверждалось, что доступность оборудования для производства цифровых валют, Распространение доверия со стороны пользователей и представителей бизнеса способствуют продвижению криптовалют и проникновению цифровых технологий. валюты в различных сферах экономической деятельности. Рассматривалось привлечение дополнительных ресурсов в экономику в условиях незначительных затрат на выход на криптовалютный рынок, которые становятся фактором распространения криптовалютных активов.
Branch of the Federal State Budgetary Educational Institution of Higher Education "Kuban State University", Slavyansk-on-Kuban The article examines the place of cryptocurrency markets in the global economy. The key risks of active implementation of IT achievements in the financial sector have been identified. It is shown that cryptocurrencies are associated with settlement transactions, investment activities and speculation in the foreign exchange markets. It was argued that the availability of equipment for the production of digital currencies, the spread of trust from users and business representatives contribute to the promotion of cryptocurrencies and the penetration of digital technologies. currencies in various fields of economic activity. It was considered to attract additional resources to the economy in conditions of insignificant costs for entering the cryptocurrency market, which are becoming a factor in the spread of cryptocurrency assets.
The economic concept by H. De Soto and its inconsistency
Authors: Матусевич А.П. 
Published: July 2024

В статье проводится анализ концепции перуанского экономиста неоинституцио нального направления Эрнандо де Сото. В первую очередь анализируется теория прав собственности, которая является краеугольным методологическим постулатом и самой теории, и практических ре комендаций на ее основе.
The article analyzes the concept of the Peruvian neo-institutional economist Hernando de Soto. First of all, the theory of property rights is analyzed, which is the cornerstone methodological postulate of both the theory itself and practical recommendations based on it.
The pharmaceutical market in Russia is the challenges of today
Authors: Просалова В.С. , Ветошкевич В.Г. , Гетман О.В. , Осипова Н.А. 
Published: July 2024

Фармацевтический рынок в России является стратегически важным не только с экономической точки зрения, как перспективное направление для инвестиций, но и играет большую социальную роль с точки зрения гарантий национальной лекарственной безопасности государства. В связи с чем следует подробно рассмотреть состояние отечественного фармацевтического рынка, проблемы и перспективы его развития. В представленной статье рассматриваются вопросы, связан ные с государственным регулированием фармацевтической отрасли, созданием и развитием фарма цевтических предприятий. Обсуждаются вопросы, связанные с локализацией иностранных фармацев тических производств.
The pharmaceutical market in Russia was strategically important not only from an economic point of view, as a promising destination for investment, but also played a large social role in guaranteeing the national drug security of the State. The state of the domestic pharmaceutical market, the problems and prospects for its development should be considered in detail. The paper addressed issues related to the State regulation of the pharmaceutical industry, the establishment and development of pharmaceutical enterprises. Issues related to localizational foreign pharmaceutical production are discussed.
ANALYSIS OF INDICATORS OF THE LEVEL OF CONCENTRATION OF MANUFACTURERS IN THE MARKET OF MANUFACTURERS OF PAPER STATIONERY
Authors: АЛАШКЕВИЧ Ю.Д. АЛАШКЕВИЧ Ю.Д. , РУБИНСКАЯ А.В. РУБИНСКАЯ А.В. , КОЖУХОВ В.А. КОЖУХОВ В.А. , САВЕНКОВ С.С. САВЕНКОВ С.С. , ВОРОНИН И.А. ВОРОНИН И.А. 
Published: July 2024

Современный рынок бумажных канцелярских принадлежностей представляет собой важный сектор, влияющий на множество отраслей и сфер деятельности. В данной статье проводится анализ показателей уровня концентрации производителей на рынке бумажных канцелярских принадлежностей с целью оценки состояния конкуренции и перспектив развития данного сегмента. Статья начинается с обзора текущей ситуации на рынке, анализа основных игроков и их доли рынка, а также рассмотрения конкурентных преимуществ и слабостей производителей. Затем проводится оценка динамики рынка. Далее авторы делают выводы, основанные на проведенном анализе. Они подчеркивают, что рынок бумажных канцелярских принадлежностей имеет умеренный уровень концентрации производителей, что способствует сохранению конкуренции и разнообразия предложений. Они также отмечают важность конкуренции для потребителей, с высоким выбором, доступными ценами и инновационными продуктами.
The modern paper stationery market is an important sector affecting many industries and fields of activity. This article analyzes the indicators of the level of concentration of manufacturers in the paper stationery market in order to assess the state of competition and prospects for the development of this segment. The article begins with an overview of the current market situation, an analysis of the main players and their market share, as well as a review of the competitive advantages and weaknesses of manufacturers. Then the market dynamics is assessed. Further, the authors draw conclusions based on the analysis. They emphasize that the paper stationery market has a moderate concentration of manufacturers, which contributes to maintaining competition and diversity of offers. They also point out the importance of competition for consumers, with high choice, affordable prices and innovative products.
SPECIFICS AND PROBLEMS OF BANKRUPTCY OF INDIVIDUALS IN THE RUSSIAN FEDERATION
Authors: АРАКЕЛЯН Г.А. АРАКЕЛЯН Г.А. 
Published: July 2024

Данная научная статья посвящена изучению специфики и проблематики банкротства физических лиц в Российской Федерации. В статье рассматривается текущее состояние и особенности банкротства физических лиц в правовом контексте России, а также анализируются основные проблемы и вызовы, с которыми сталкиваются граждане, находящиеся в процессе банкротства. Особое внимание уделяется законодательным актам, регулирующим процедуры банкротства физических лиц, и предлагаемым мерам по улучшению данной ситуации.
This scientific article is devoted to the study of the specifics and problems of bankruptcy of individuals in the Russian Federation. The article examines the current state and features of bankruptcy of individuals in the legal context of Russia, and also analyzes the main problems and challenges faced by citizens in the process of bankruptcy. Particular attention is paid to legislative acts regulating bankruptcy procedures for individuals and proposed measures to improve this situation.