bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lesion Sterilization Tissue Repair as Adjunct to Conventional Root Canal Treatment of Combined Periodontic-Endodontic Cases
Authors: Saleh Ahmed A , Eid Hossam A , Abdelaziz Khalid M 
Published: March 2014

ABSTRACT

Background
Treatment of perio-endo lesions is challenging for the clinician. A combination of root canal treatment and periodontal treatment is needed in order to provide good results. There is a high failure rate due to the difficulty in eliminating the microflora that colonizes and complicates the lesion. Conventional root canal treatment (RCT) sometimes is not enough to prevent failure in such lesions. Hence the Aim of this study was to evaluate of use of LSTR (Lesion Sterilization Tisssue Repair) therapy in conjunction with, periodontal therapy and RCT in management of combined perio-endo lesions.

Materials and methods
This study was conducted on 26 patients with perio-endo lesions, The affected teeth were tender to percussion, presented no mobility, and meticulous periodontal probing revealed all pockets to be more than 6 mm in depth. Periapical radiographs of the teeth confirmed the extensive coronal carious lesion involving the pulp and revealed large periapical lesion. The patients were classified into two groups, each of 14 patients, control group (A) RCT done by using conventional sealer, and group (B), RCT done by mixing sealer with LSTR material in equal proportions. All teeth were treated by open flap debridement.

Results
In group B patients, after follow-up for 3, 6, 9 and 12 months, we found excellent prognosis (98%), with no symptoms of pain and there was marked improvement in periodontal parameters for all teeth. However, on the other hand, in group A patients, the prognosis was found to be 90%.

Conclusion
According to results of this study, we highly recommend the use of LSTR with sealer in RCT together with periodontal treatment in management of perio-endo lesions to decrease the rate of failure and improve the periodontal condition.

How to cite this article
Saleh AA, Eid HA, Abdelaziz KM. Lesion Sterilization Tissue Repair as Adjunct to Conventional Root Canal Treatment of Combined Periodontic-Endodontic Cases. World J Dent 2014;5(1):47-52.
Customized Bluegrass Appliance
Authors: Surendran Sharmila , Amarlal Deepti , Thomas Eapen 
Published: March 2014

ABSTRACT

Background
Digit sucking is a common childhood behavior, which has an adaptive value for children up to the fourth year of life. Chronic prolonged habit may cause deleterious effects on dentofacial structures. Reminder therapy using blue grass appliance has been proven successful to intercept thumb sucking habit.

Methods
Four cases of digit sucking were corrected by nonpunitive reminder therapy using customized blue grass appliance.

Results and conclusion
Four patients’ digit sucking habit ceased after the insertion of the customized bluegrass appliance. These appliances were very comfortable to the patient and successful in intercepting the habit within a short period of time. It is an effective treatment option with limited treatment complications.

How to cite this article
Surendran S, Amarlal D, Asokan S, Thomas E. Customized Bluegrass Appliance. World J Dent 2014;5(1):64-66.
Interactions between Restorative Dentistry and Periodontics: Luting Post Nonmetallic (Part II)
Authors: Tonetto Mateus Rodrigues , Pinto Shelon Cristina Souza , Borges Alvaro Henrique , Saad José Roberto Cury , Bandéca Matheus Coelho , Frizzera Fausto , de Figueiredo Pereira Kamila , dos Santos Reidson Stanley Soares 
Published: March 2014

ABSTRACT
Endodontically treated teeth have necessary use of intracanal posts. Due to the constant need and search for esthetic materials with properties similar to tooth structure remaining fiberglass posts esthetic came good these shortcomings and are increasingly used as a first option for prosthetic rehabilitation. In this case report is described step by step how to perform the cementation of a nonmetallic post and core construction for making a piece prosthetic onlay in a simplified way, by choosing the self-etching cementation technique.

How to cite this article
Bandéca MC, Pinto SCS, Tonetto MR, Frizzera F, de Figueiredo Pereira K, Borges AH, Saad JRC, dos Santos RSS. Interactions between Restorative Dentistry and Periodontics: Luting Post Nonmetallic (Part II). World J Dent 2014;5(1):72-75.
Le transfert de connaissances au RRSSTQ
Authors: Lortie Monique , Desmarais Lise , Faye Cheikh , Laroche Éléna , Faurie Isabelle 
Published: March 2014

Cet article a pour objectif de poser un regard rétrospectif sur les activités scientifiques et les réflexions menées par le regroupement stratégique en transfert de connaissances (RS-TC) afin de dégager des axes de développement sur ce thème en lien avec la santé et sécurité au travail (SST). Afin de dresser ce bilan, nous avons effectué une analyse documentaire à partir de deux sources principales : 1) les activités de type symposiums et tables rondes organisées successivement en 2005, 2006, 2008, 2010 et 2011 et les diverses présentations et publications qui en sont issues et 2) les revues de littérature effectuées sur le transfert des connaissances en SST. Nous présentons d’abord un bref portrait des activités de transfert en SST réalisées par le RS-TC du Réseau de recherche en santé et sécurité du travail (RRSSTQ). Par la suite, nous proposons diverses pistes de réflexion développées à partir des activités menées depuis la création de ce regroupement au sein du RRSSTQ. Par exemple, le piège de restreindre le sens du terme connaissance et de s’y astreindre, le choix d’un intitulé représentatif de la question du transfert au Réseau, la nécessité d’opérer une double articulation individu/organisation, l’importance et la complexité du rôle des relayeurs, la multiplicité des outils de relais, la problématique de l’implantation. Nous terminons sur une piste de réflexion encore inexplorée par la communauté de chercheurs en TC de ce regroupement – les décideurs, auxquels peu d’efforts ont été consacrés – et sur les suites à donner au travail réalisé à ce jour : développer un cadre d’analyse propre à rendre compte des savoirs et savoir-faire développés au Réseau.
Comparison of upscaled models for multistage mass discharge from DNAPL source zones
Authors: Kokkinaki A. , Werth C. J. , Sleep B. E. 
Published: March 2014

AbstractAnalytical upscaled models that can describe the depletion of dense nonaqueous phase liquids (DNAPLs) and the associated mass discharge are a practical alternative to computationally demanding and data‐intensive multiphase numerical simulators. A major shortcoming of most existing upscaled models is that they cannot reproduce the nonmonotonic, multistage effluent concentrations often observed in experiments and numerical simulations. Upscaled models that can produce multistage concentrations either require calibration, which increases the cost of applying them in the field, or use dual‐domain conceptual models that may not apply for spatially complex source zones. In this study, a new upscaled model is presented that can describe the nonmonotonic, multistage average concentrations emanating from complex DNAPL source zones. This is achieved by explicitly considering the temporal evolution of three source zone parameters, namely source zone projected area, the average of local‐scale DNAPL saturations, and the average of local‐scale aqueous relative permeability, without using empirical parameters. The model is evaluated for two real and twelve hypothetical centimeter‐scale complex source zones. The proposed model captures the temporal variations in concentrations better than an empirical model and a dual‐domain ganglia‐to‐pool ratio model. The results provide evidence that effluent concentrations downgradient of DNAPL source zones are controlled by the evolution of the aforementioned macroscopic parameters. This knowledge can be useful for the interpretation of field observations of effluent concentrations downstream of DNAPL source zones, and for the development of predictive upscaled models. Advances in DNAPL characterization techniques are needed to quantify these macroscopic parameters that can be used to guide DNAPL remediation efforts.
Altitudinal gradients, midwinter melt, and wind effects on snow accumulation in semiarid midlatitude Andes under La Niña conditions
Authors: Ayala A. , McPhee J. , Vargas X. 
Published: March 2014

AbstractThe Andes Cordillera remains a sparsely monitored and studied snow hydrology environment in comparison to similar mountain ranges in the Northern Hemisphere. In order to uncover some of the key processes driving snow water equivalent (SWE) spatial variability, we present and analyze a distributed SWE data set, sampled at the end of accumulation season 2011. Three representative catchments across the region were monitored, obtaining measurements in an elevation range spanning 2000 to 3900 m asl and from 32.4° to 34.0°S in latitude. Climatic conditions during this season corresponded to a moderate La Niña phenomenon, which is generally correlated with lower‐than normal accumulation. Collected measurements can be described at the regional and watershed extents by altitudinal gradients that imply an increase by a factor of two in snow depth between 2200 and 3000 m asl, though with significant variability at the upper sites. In these upper sites, we found north‐facing, wind‐sheltered slopes showing 25% less average SWE values than south‐facing, wind‐exposed ones. This suggests that under these conditions, solar radiation dominated wind transport effects in controlling end‐of‐winter variability. Nevertheless, we found clusters of snow depth measurements above 3000 m asl that can be explained by wind exposure differences. This is the first documented snow depth data set of this spatial extent for this region, and it is framed within an ongoing research effort aimed at improving understanding and modeling of snow hydrology in the extratropical Andes Cordillera.
The Broader Autism Phenotype
Authors: Ingersoll Brooke , Wainer Allison 
Published: March 2014

AbstractThe broader autism phenotype (BAP) has been conceptualized as a constellation of subclinical traits that parallel the deficits observed in individuals with autism spectrum disorder (ASD). The BAP is thought to represent an intermediate phenotype that is more frequently observed in family members of individuals with ASD. This chapter discusses methodological issues in the assessment of the BAP and describes the domains thought to characterize the BAP in family members and in the general population. It also provides a brief discussion of the etiological significance of the BAP.
X‐linked hypohidrotic ectodermal dysplasia (XLHED): Clinical and diagnostic insights from an international patient registry
Authors: Fete Mary , Hermann Julie , Behrens Jeffrey , Huttner Kenneth M. 
Published: March 2014

The web‐based Ectodermal Dysplasia International Registry (EDIR) is a comprehensive patient‐reported survey contributing to an understanding of ectodermal dysplasia (ED). XLHED is the most common of the genetic ED syndromes and was the primary diagnosis reported by 223/835 respondents (141 males and 82 females). Overall, 96% of XLHED registrants reported as least one other affected family member and 21% reported a family history of infant or childhood deaths, consistent with the published mortality data in this disorder. In general, XLHED is diagnosed by the triad of decreased sweating, reduced hair, and hypodontia (present in 89%, 74%, and 74% of XLHED respondents). Additionally, the registry dataset confirmed a spectrum of life‐long XLHED clinical complications including recurrent sinus infections (49% males, 52% females), nasal congestion often foul smelling and interfering with feeding (73% males, 27% females), eczema (66% males, 40% females), wheezing (66% males, 45% females), and a hoarse, raspy voice (67% males, 23% females). The Registry results also highlighted features consistently differentiating XLHED from the non‐hypohidrotic ED syndromes including the frequency of infant/childhood deaths, the presence of limb/digit abnormalities, feeding issues related to nasal discharge, dentures, and a diagnosis of asthma.These results represent the largest collection of data on a broad‐spectrum of health‐related issues affecting ED patients. This project provides information for expanding knowledge of the natural history of XLHED, and as such may facilitate the diagnosis and treatment of its varied and lifelong medical challenges. © 2014 Wiley Periodicals, Inc.
Mutation spectrum of COL1A1 and COL1A2 genes in Indian patients with osteogenesis imperfecta
Authors: Stephen Joshi , Shukla Anju , Dalal Ashwin , Girisha Katta Mohan , Shah Hitesh , Gupta Neerja , Kabra Madhulika , Dabadghao Preeti , Phadke Shubha R. 
Published: March 2014

ABSTRACTOsteogenesis imperfecta (OI) is a condition of decreased bone density with heterogeneous etiologies. Most of the cases are inherited in an autosomal dominant fashion and are caused by mutations in the COL1A1 or COL1A2 genes. Since these two genes are very large, there are no data about mutations in Indian patients with OI. We selected 35 Indian patients who were clinically diagnosed with OI and all exons of both the genes were sequenced. Mutations in COL1A1 (14 cases, 6 novel) and COL1A2 (11 cases, 7 novel) were identified in 25 patients. A total of 55 polymorphisms were identified in both the genes with eight novel variants in the coding region, and nine novel variants in the non‐coding regions. No mutation was detected in 10 patients. Six of them were from consanguineous families, with one or two similarly affected siblings suggesting possible autosomal recessive inheritance. If we exclude families with consanguinity, mutations were identified in 25 out of 29 families giving 86% mutation detection rate. Mutations in COL1A1 accounted for 56% of the cases and COL1A2 44%, which is similar to the reported rate worldwide. © 2014 Wiley Periodicals, Inc.
Efficient Solid‐Phase Synthesis of pppRNA by Using Product‐Specific Labeling
Authors: Goldeck M. , Tuschl T. , Hartmann G. , Ludwig J. 
Published: March 2014

AbstractA novel solid‐phase synthesis and purification strategy for 5′‐triphosphate oligonucleotides by using lipophilic tagging of the triphosphate moiety is reported. This is based on triphosphate synthesis with 5′‐O‐cyclotriphosphate intermediates, whereby a lipophilic tag, such as decylamine, is introduced during the ring‐opening reaction to give a linear gamma‐phosphate‐tagged species. This method enables the highly efficient synthesis of 5′‐triphosphorylated RNA derivatives and their gamma‐phosphate‐substituted analogues and will especially facilitate the advancement of therapeutic approaches that make use of 5′‐triphosphate oligonucleotides as potent activators of the cytosolic immune sensor RIG‐I.
Carbon Fibers: Precursor Systems, Processing, Structure, and Properties
Authors: Frank Erik , Steudle Lisa M. , Ingildeev Denis , Spörl Johanna M. , Buchmeiser Michael R. 
Published: March 2014

AbstractThis Review gives an overview of precursor systems, their processing, and the final precursor‐dependent structure of carbon fibers (CFs) including new developments in precursor systems for low‐cost CFs. The following CF precursor systems are discussed: poly(acrylonitrile)‐based copolymers, pitch, cellulose, lignin, poly(ethylene), and new synthetic polymeric precursors for high‐end CFs. In addition, structure–property relationships and the different models for describing both the structure and morphology of CFs will be presented.
Separation of Photoactive Conformers Based on Hindered Diarylethenes: Efficient Modulation in Photocyclization Quantum Yields
Authors: Li Wenlong , Jiao Changhong , Li Xin , Xie Yongshu , Nakatani Keitaro , Tian He , Zhu Weihong 
Published: March 2014

AbstractEndowing both solvent independency and excellent thermal bistability, the benzobis(thiadiazole)‐bridged diarylethene system provides an efficient approach to realize extremely high photocyclization quantum yields (Φo‐c, up to 90.6 %) by both separating completely pure anti‐parallel conformer and suppressing intramolecular charge transfer (ICT).
Bidirectional Chemical Communication between Nanomechanical Switches
Authors: Pramanik Susnata , De Soumen , Schmittel Michael 
Published: March 2014

AbstractThe interplay of biological machines depends critically on the bidirectionality of chemical information exchange. The implementation of such a communication procedure for abiological systems is achieved using two nanoswitches that both operate as transmitters and receivers by transfering copper ions in oxidation states +I and +II. Even at micromolar concentrations, communication in both directions is remarkably fast, occurring at t1/2=2–3 min. Metal ion translocation triggers a 20 Å relocation of the toggle at both nanoswitches, entailing major geometric and electronic changes.
Total Synthesis of Syringolin A and Improvement of Its Biological Activity
Authors: Chiba Takuya , Hosono Hidetaka , Nakagawa Koji , Asaka Masahiro , Takeda Hiroshi , Matsuda Akira , Ichikawa Satoshi 
Published: March 2014

AbstractThe development process for syringolin A analogues having improved proteasome inhibitory and antitumor activity is described. The strategy was to first establish a convergent synthesis of syringolin A using a rare intramolecular Ugi three‐component reaction in the last stage of the synthesis, so as to gain access toa set of structure‐based analogues. The inhibitory activity of chymotrypsin‐like activity of 20S proteasome was largely improved by targeting the S3 subsite of the β5 subunit. Cytotoxic activity was also improved by installing the membrane‐permeable substituent. These biological properties are comparable to those of bortezomib, a clinically used first‐line proteasome inhibitor.
Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein
Authors: Bhattacharyya Aditi , Mukhopadhyay Piyasi , Kundu P. P. 
Published: March 2014

ABSTRACTWith the aim of using poly(ethylene terephthalate) (PET) waste for the synthesis of a value added product, we prepared polyurethane (PU) from bishydrohxyethylene terephthalate (BHET), a byproduct obtained from the glycolysis of PET. Biodegradable, water‐swelling PU was synthesized by the reaction of BHET, hexamethylene diisocyanate, and poly(ethylene glycol) (PEG). Both BHET and PU were characterized by Fourier transform infrared spectroscopy, and the formation of PU was further confirmed by NMR analysis. The swelling behavior of PU in water was examined in terms of the various molecular weights of PEG. Semi‐interpenetrating network beads of PU and sodium alginate were prepared with calcium chloride (CaCl2) as a crosslinker to attain a pH sensitivity for successful oral protein/drug delivery. Bovine serum albumin (BSA) was used as a model protein. The pH‐responsive swelling behavior and protein (BSA) release kinetics in different pH media corresponding to the gastrointestinal tract (pH 1.2 and 7.4) were investigated. The degree of swelling in the case of the PU–alginate beads at pH 1.2 was found to be at a minimum, whereas the degree of swelling was significantly elevated (1080%) at pH 7.4. This substantiated the pH sensitivity of the polymeric beads with a minimum loss of encapsulated protein in the stomach and the almost complete release of encapsulated protein in the intestine. This revealed good opportunities for oral protein/drug delivery with a polymer derived from waste PET. Moreover, the fungal biodegradation study confirmed its compatibility with the ecological system. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40650.
Effect of Various Intercalators on the Fenton‐Type Oxidative Cleavage of Double‐Stranded DNA
Authors: Kim Hyeon Jeong , Sung Giwoong , Kim Gyeongwon , Park Jongjin , Jin Biao , Kim Seog K. 
Published: March 2014

AbstractThe intensity of the linear dichroism (LD) in the absorption region of DNA (about 260 nm) decreased with time in the presence of [Fe(EDTA)]2+ (EDTA=ethylenediaminetetraacetic acid), H2O2, and ascorbate. The decrease in the LD signal indicated either an increase in flexibility, a shortening of the DNA stem, or both, owing to oxidative cleavage, and was best described by the difference between the two single‐exponential‐decay curves, thereby suggesting the involvement of two sequential first‐order reactions. The fast reaction was assigned to cleavage of one of two DNA strands, which increased the flexibility of the DNA. The slow reaction corresponded to cleavage at or near the first cleavage site, thereby shortening the DNA stem. The presence of an intercalator, including ethidium, propidium, 9‐aminoacridine, and proflavine, inhibited the first step of the cleavage reaction. One of the possible reasons for the observed inhibition might be a change in the DNA conformation near the intercalation site. Intercalation caused an unwinding and elongation of the DNA and resulted in changes in the location of the H atoms of the sugar moiety, which is known to be the main site at which hydroxyl radicals react.
The effect of oxygen tension on human articular chondrocyte matrix synthesis: Integration of experimental and computational approaches
Authors: Li S. , Oreffo R.O.C. , Sengers B.G. , Tare R.S. 
Published: March 2014

ABSTRACTSignificant oxygen gradients occur within tissue engineered cartilaginous constructs. Although oxygen tension is an important limiting parameter in the development of new cartilage matrix, its precise role in matrix formation by chondrocytes remains controversial, primarily due to discrepancies in the experimental setup applied in different studies. In this study, the specific effects of oxygen tension on the synthesis of cartilaginous matrix by human articular chondrocytes were studied using a combined experimental‐computational approach in a “scaffold‐free” 3D pellet culture model. Key parameters including cellular oxygen uptake rate were determined experimentally and used in conjunction with a mathematical model to estimate oxygen tension profiles in 21‐day cartilaginous pellets. A threshold oxygen tension (pO2 ≈ 8% atmospheric pressure) for human articular chondrocytes was estimated from these inferred oxygen profiles and histological analysis of pellet sections. Human articular chondrocytes that experienced oxygen tension below this threshold demonstrated enhanced proteoglycan deposition. Conversely, oxygen tension higher than the threshold favored collagen synthesis. This study has demonstrated a close relationship between oxygen tension and matrix synthesis by human articular chondrocytes in a “scaffold‐free” 3D pellet culture model, providing valuable insight into the understanding and optimization of cartilage bioengineering approaches. Biotechnol. Bioeng. 2014;111: 1876–1885. © 2014 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc.