bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of social disadvantage in moderate-to-severe chronic kidney disease: an equity-focused systematic review*
Authors: Morton Rachael Lisa , Schlackow Iryna , Mihaylova Borislava , Staplin Natalie Dawn , Gray Alastair , Cass Alan 
Published: January 2015

AbstractIt is unclear whether a social gradient in health outcomes exists for people with moderate-to-severe chronic kidney disease (CKD). We critically review the literature for evidence of social gradients in health and investigate the ‘suitability’ of statistical analyses in the primary studies. In this equity-focused systematic review among adults with moderate-to-severe CKD, factors of disadvantage included gender, race/ethnicity, religion, education, socio-economic status or social capital, occupation and place of residence. Outcomes included access to healthcare, kidney disease progression, cardiovascular events, all-cause mortality and suitability of analyses. Twenty-four studies in the pre-dialysis population and 34 in the dialysis population representing 8.9 million people from 10 countries were included. In methodologically suitable studies among pre-dialysis patients, a significant social gradient was observed in access to healthcare for those with no health insurance and no home ownership. Low income and no home ownership were associated with higher cardiovascular event rates and higher mortality [HR 1.94, 95% confidence interval (CI) 1.27–2.98; HR 1.28, 95% CI 1.04–1.58], respectively. In methodologically suitable studies among dialysis patients, females, ethnic minorities, those with low education, no health insurance, low occupational level or no home ownership were significantly less likely to access cardiovascular healthcare than their more advantaged dialysis counterparts. Low education level and geographic remoteness were associated with higher cardiovascular event rates and higher mortality (HR 1.54, 95% CI 1.01–2.35; HR 1.21, 95% CI 1.08–1.37), respectively. Socially disadvantaged pre-dialysis and dialysis patients experience poorer access to specialist cardiovascular health services, and higher rates of cardiovascular events and mortality than their more advantaged counterparts.
Bolshevism Debated, 1921–1932
Authors: Gorsuch Anne E. 
Published: January 2015

Abstract
Focusing on the transnational flow and exchange of ideas, rather than on divisions and borders, this chapter emphasizes the ways in which early debates about ‘Sovietness’ related to multiple imaginings, understandings, and experiences of the ‘West’. This perspective builds on work that has reconsidered the history of the Soviet Union within the larger framework of European and North American modernity. ‘Being Soviet’ in the formative years of Bolshevism included ideas, technologies, and cultures that were ‘Western’. Some were openly and positively identified as such; others were covert or unacknowledged. The relationship was deeply ambivalent. But the resultant heterodoxy was notably different from Cold War concepts of the Soviet Union as rigid and impermeable.
Jonson’s Critical History
Authors: Sterling Eric 
Published: January 2015

AbstractThis chapter provides an overview of Jonson scholarship since 1900. The Biography section focuses on his social class, relationship with his family and peers, and his education. Edited and general literary criticism covers many seminal articles that appeared in print in edited collections. These books cover genre studies, the impact of the failed comedy The New Inn on his reputation, and analysis of the great comedies such as Volpone and The Alchemist, the epigrams, and other works. The poetry section covers classical influences, patronage, and the poet as a self-conscious craftsman. The section on masques discusses the influence of Inigo Jones, the use of spectacle, and Jonson’s desire for patronage and his political motivations. The final section covers the great comedies and the lesser-known dramas, focusing on satire, Jonson’s concern for his reputation, and the rise and fall of his career.
Lessons from Ethnic Studies
Authors: Fong Kelly , Lai Clement 
Published: January 2015

Abstract
This chapter argues for interdisciplinary collaboration between historical archaeology and Asian American Studies/Ethnic Studies, and it articulates a Chinese American historical archaeology. Both fields stand to benefit from collaboration, with the potential for contributions to archaeological work in the Chinese diaspora more broadly. Ethnic Studies brings to historical archaeology a more nuanced understanding about race, specifically with regard to theories of racialization and racial triangulation, as well as decades of experience doing politically conscious, community-engaged, anti-racist work. Historical archaeology provides Ethnic Studies with a framework for studying material culture, something that Ethnic Studies scholars have yet to study in depth, in conjunction with oral histories and the documentary record. Furthermore, interdisciplinary collaboration has the potential for reorienting Ethnic Studies towards researching community social histories. The chapter argues for continued interdisciplinary collaboration to promote historical archaeologies of Chinese Americans and of Asian Americans more broadly.
Culture, Language, and Number
Authors: Saxe Geoffrey B. 
Published: January 2015

Abstract
Some time ago, Bryant (1997) remarked, ‘Piaget and Vygotsky set the scene for much of the work that has been done over the last twenty years or so on children’s mathematical understanding.’ (p. 142.) Today, Piaget and Vygotsky’s conceptual and empirical frameworks still define principal contours of contemporary work on cognitive development. In introducing this section on culture, language, and number with chapters by Okamoto, Towse, Nunez and Marghetis, and Sturman, I situate the authors’ contributions in relation to Vygotsky’s and Piaget’s seminal writings and some contemporary strands of empirical and conceptual inquiry. I am particularly attentive to the way the authors extend ideas that were core to Piaget’s and Vygotsky’s writings.
Transatlantic Music Studies
Authors: Goodman Glenda 
Published: January 2015

Abstract
Transatlantic music studies is a growing field in music scholarship that investigates music, musicians, and ideas about music that circulated around the Atlantic Ocean from the fifteenth century to today. It is an interdisciplinary field that draws on Atlantic history to understand how music was shaped by—and helped to shape—the Atlantic world. Transatlantic music studies makes two significant contributions to musicology: it brings a distinctly transnational orientation to scholarship, and it highlights the important role of intercultural encounter and the contributions of non-white musicians in Western music history, particularly in the early modern period. This essay outlines the parameters and theoretical precepts of transatlantic music studies and delineates three methods for pursuing research: tracing the circulation of ideas and materials; conducting micro-historical investigations of the experiences of individuals; and mapping key locations in the cis- and circum-Atlantic world.
GWAS‐Identified Common Variants With Nonalcoholic Fatty Liver Disease in Chinese Children
Authors: Shang Xiao‐Rui , Song Jie‐Yun , Liu Fang‐Hong , Ma Jun , Wang Hai‐Jun 
Published: January 2015

ABSTRACTObjectives:Three genome‐wide association studies were previously done for nonalcoholic fatty liver disease (NAFLD) among individuals of Western countries and identified several genetic variants associated with NAFLD. The study aimed to identify whether 7 GWAS‐identified common variants (GCKR rs780094, PDGFA rs343064, FDFT1 rs2645424, COL13A1 rs1227756, EHBP1L1 rs6591182, NCAN rs2228603, and PNPLA3 rs738409) were associated with NAFLD in Chinese children.Methods:This case‐control study recruited 1027 Chinese children of age 7 to 18 years, including 162 children with NAFLD and 865 children without NAFLD. Anthropometric measurements, alanine transaminase (ALT) detection, liver ultrasound examination, and genotyping of 7 variants were performed.Results:The G‐allele of PNPLA3 rs738409 was associated with NAFLD (odds ratio [OR] 1.55, 95% confidence interval 1.13–2.11, P = 0.006) and moderate‐to‐severe steatosis (OR 3.77, 95% confidence interval 1.78–7.98, P = 0.001) adjusted for age, sex, and BMI standard deviation score. In addition, we found each G‐allele of rs738409 increased ALT level by 1.09 IU/L (P = 0.011). Subjects carrying 10 or more risk alleles of 7 variants had an OR of 4.76 (P = 0.025) for NAFLD compared with subjects carrying 3 or fewer risk alleles.Conclusions:The PNPLA3 rs738409 G‐allele was associated with NAFLD and ALT level in Chinese children. It had stronger association with moderate‐to‐severe steatosis. Children carrying 10 or more risk alleles of 7 variants were susceptible for NAFLD.
MMPs‐2 and ‐14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy
Authors: Beppu Lisa , Yang Tom , Luk Michelle , Newbury Robert O. , Palmquist Jacob , Dohil Ranjan , Kurten Richard C. , Broide David H. , Aceves Seema S. 
Published: January 2015

ABSTRACTObjectives:Eosinophilic esophagitis (EoE) is a chronic, antigen‐mediated disease in children and adults associated with substantial esophageal remodeling and fibrosis. The expression of the remodeling‐associated matrix metalloproteinases (MMPs) has not been previously detailed in EoE.Methods:MMP‐2 and ‐14 expression and cellular localization were assessed using real‐time quantitative polymerase chain reaction and immunohistochemistry/immunofluorescence in EoE fibroblasts, active and inactive pediatric EoE biopsies, and nondiseased control biopsies. The effect of transforming growth factor (TGF)‐β1 treatment on MMP‐2 expression in cultured esophageal epithelial (HET1A) cells was analyzed.Results:MMP‐2 and ‐14 mRNA were expressed in EoE fibroblasts and biopsies. Proliferating epithelial cells produced MMP‐14 more abundantly in EoE than in controls (P < 0.001) and the degree of epithelial MMP‐14 expression correlated positively with basal zone hyperplasia (r = 0.65, P = 0.002). EoE lamina propria had higher numbers of MMP‐2‐ and ‐14‐positive cells (906 ± 167 and 701 ± 93 cells/mm2) as compared with controls (258 ± 93 cells/mm2, P < 0.01 and 232 ± 54 cells/mm2, P < 0.01), and MMP‐14 expression correlated with the severity of fibrosis. Following therapy with topical corticosteroids, MMP‐14 and ‐2 were significantly diminished (P < 0.01). TGF‐β1 increased the expression and secretion of MMP‐2 from esophageal epithelial HET1A cells.Conclusions:MMP‐2 and ‐14 are elevated in pediatric patients with EoE and significantly decrease following topical corticosteroid therapy. TGF‐β1 increases MMP‐2 in esophageal epithelial cells. This alludes to previously unappreciated role for MMPs in EoE‐associated esophageal remodeling and a potential positive feedback loop via TGF‐β1.
Use of Lactobacillus casei rhamnosus to Prevent Cholangitis in Biliary Atresia After Kasai Operation
Authors: Lien Tien‐Hau , Bu Ling‐Nan , Wu Jia‐Feng , Chen Huey‐Ling , Chen An‐Chyi , Lai Ming‐Wei , Shih Hsiang‐Hung , Lee I‐Hsien , Hsu Hong‐Yuan , Ni Yen‐Hsuan , Chang Mei‐Hwei 
Published: January 2015

ABSTRACTObjectives:Recurrent cholangitis may aggravate cholestatic liver cirrhosis in biliary atresia (BA) after the Kasai operation. This pilot study aimed to investigate whether Lactobacillus casei rhamnosus has the prophylactic efficacy for recurrent cholangitis in comparison with the conventional neomycin prophylaxis.Methods:Twenty jaundice‐free patients with BA ages 0 to 3 years who underwent a Kasai operation were enrolled and randomized into 2 groups with 10 patients each: neomycin (25 mg · kg−1 · day−1 for 4 days/wk) and L casei rhamnosus (8 × 108 colony‐forming unit per day) groups. The treatment duration was 6 months. Bacterial stool cultures were performed before treatment and 1, 3, and 6 months after starting treatment. In addition, 10 patients with BA with similar status but without prophylaxis served as the historical control group.Results:In the Lactobacillus group, 2 patients (20%, mean 0.03 ± 0.07 episodes per month) developed cholangitis during the study period, with the same frequency as in the neomycin group and significantly lower than that in the control group (80%, P = 0.005, mean 0.22 ± 0.16 episodes per month). The mean change in body weight z score during the 6 months in the Lactobacillus group was 0.97 ± 0.59, which was significantly better than that in the control group (−0.01 ± 0.79, P = 0.006). In bacterial stool cultures, the Lactobacillus and Escherichia coli populations significantly increased and decreased, respectively, in the Lactobacillus group.Conclusions:The use of L casei rhamnosus was as effective as neomycin in preventing cholangitis in patients with BA who underwent Kasai operation, and therefore could be considered as a potential alternative prophylactic regimen.
Laboratory Procedures Update on Hirschsprung Disease
Authors: Takawira Catherine , D'Agostini Stephanie , Shenouda Suzan , Persad Rabin , Sergi Consolato 
Published: January 2015

ABSTRACTObjectives:The detection of ganglion cells in rectal biopsies of infants or toddlers with severe constipation is routinely performed by pediatric pathologists in many institutions. Hirschsprung disease (HD) is defined by the lack of ganglion cells (aganglionosis). The early recognition and the prompt implementation of surgical procedures obviously protect infants affected with HD from potential life‐threatening conditions, including enterocolitis and debilitating constipation. Image‐based and non–image‐based clinical techniques and some laboratory tests have been reevaluated along the years, but often fragmentarily. Immunohistochemical markers have been increasingly used in pathology laboratories to detect ganglion cells and nerve fibers. Recently, calretinin, a vitamin D–dependent calcium‐binding protein with expression in ganglion cells and nerves, has been described as an adjunctive or primary diagnostic test in HD. The aim of the present study was to systematically summarize and update laboratory procedures targeting ganglion cells in rectal biopsies.Methods:Procedures and tests have been reviewed and values of specificity and sensitivity have been calculated according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines.Results:Contrast enema has the lowest sensitivity and specificity of all of the 3‐index investigations under the lens: contrast enema, anorectal manometry, and biopsy with histology. The latter procedure seems to have the highest sensitivity and specificity. Acetylcholinesterase staining on fresh‐frozen material has been found to have slightly higher rates of sensitivity and specificity when compared with hematoxylin and eosin only. Calretinin staining may be supportive for the diagnosis, although some cases with false‐positivity may be of some concern.Conclusions:Hematoxylin and eosin with or without acetylcholinesterase remains the criterion standard according to our PRISMA‐based data. In our opinion, the number of false‐positive results with potential overtreatment may limit the increasing advocacy for calretinin staining. Both the “primum non nocere” dictum and the “loss aversion heuristic” need to be satisfied harmoniously by preventing harm from unnecessary surgery.
Celiac Disease Can Be Predicted by High Levels of Anti‐Tissue Transglutaminase Antibodies in Population‐Based Screening
Authors: Webb Charlotta , Norström Fredrik , Myléus Anna , Ivarsson Anneli , Halvarsson Britta , Högberg Lotta , Lagerqvist Carina , Rosén Anna , Sandström Olof , Stenhammar Lars , Carlsson Annelie 
Published: January 2015

ABSTRACTObjectives:The aim of the present study was to evaluate any potential correlation between anti‐tissue transglutaminase antibodies of type immunoglobulin A (tTG‐IgA) and the degree of gluten‐induced enteropathy in children participating in a screening study for celiac disease (CD) and to assess to what extent the revised European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines cover this group of patients.Methods:The present study is a substudy of a cross‐sectional CD screening study, Exploring the Iceberg of Celiacs in Sweden, a 2‐phased study performed during 2005 to 2006 and 2009 to 2010. The 13,279 participating children had a blood test obtained, and those with positive tTG‐IgA were recommended a small intestinal biopsy. The tTG‐IgA levels at the time of biopsy were compared with those at the assessment of the biopsy.Results:There were 267 children included, of whom 230 were diagnosed as having CD. Of all of the children, 67 children had low tTG‐IgA levels (<5 U/mL), of whom 55% had Marsh 3 lesions. All of the children with tTG‐IgA levels exceeding 10 times the upper limit of normal values of 5 U/mL, that is, 50 U/mL, were diagnosed as having CD. Lowering the cutoff to 3 U/mL, all but 1 child with 30 U/mL got CD diagnosis.Conclusions:By adopting the revised ESPGHAN criteria, biopsies could have been omitted in one‐fourth of all of the patients. Our results indicate that the criteria may be useful even in screened children. Further studies are needed to confirm whether the 2012 ESPGHAN guidelines should be revised to also apply to the populations being screened.
Dietary Nucleotide and Nucleoside Exposure in Infancy and Atopic Dermatitis, Recurrent Wheeze, and Allergic Sensitization
Authors: Timmermans Marijke J.C. , Dagnelie Pieter C. , Theunisz Esther H.E. , Ewalds Doreen , Thijs Carel , Mommers Monique , Arts Ilja C.W. 
Published: January 2015

ABSTRACTWe hypothesized that early life exposure to nucleotides and nucleosides lowers the risk of recurrent wheeze, atopic dermatitis, and allergic sensitization among n = 429 children. Concentrations in breast milk were established by high‐performance liquid chromatography; concentrations in formula milks were obtained from manufacturers. Questionnaires and home visits were used to assess outcomes. Adjusted odds ratios in the highest tertile compared with those in the lowest tertile of exposure ranged from 1.11 to 1.99 in predominantly formula‐fed children, and from 0.40 to 0.53 in predominantly breast‐fed children, but were not significant. Thus, we found no evidence for association between nucleotide and nucleoside exposure and the development of atopic outcomes in children up to 2 years.
Early Introduction of Complementary Foods in Preterm Infants
Authors: Braid Susan , Harvey Elizabeth M. , Bernstein Jenny , Matoba Nana 
Published: January 2015

ABSTRACTObjectives:The aim of the present study was to determine the odds of early introduction of solid foods in a nationally representative sample of preterm infants when compared with term infants and to examine whether factors associated with early introduction are the same for preterm and term infants.Methods:Our sample of 7650 came from the first wave of the Early Childhood Longitudinal Study, Birth Cohort (2001–2002). We performed multivariable logistic regression to determine whether preterm infants were introduced to solid foods more frequently before 4 months than term infants using adjusted age for preterm infants and chronological age for term infants. In a separate analysis in preterm infants, we used multivariable logistic regression to determine whether the factors associated with early introduction in term infants were the same in the preterm sample.Results:Infants born 22 to 32 weeks' gestation had a 9.90 (95% confidence interval 5.54–18.0) odds of being fed solid food before 4 months compared with term infants, and infants born 33 to 36 weeks' gestation had a 6.19 (95% confidence interval 4.58–8.36) odds. Race/ethnicity and maternal smoking were the only factors that predicted early solid feeding in both preterm and term infants; the remaining predictors differed.Conclusions:Preterm infants are significantly more likely to be introduced to complementary foods early compared with term infants. The predictors of early solid feeding differ for preterm infants. Given the health implications, specific guidelines for preterm infants should be developed and future research should examine predictors of early introduction in preterm infants.
Understanding the Biochemical Basis of Temperature-Induced Lipid Pathway Adjustments in Plants
Authors: Li Qiang , Zheng Qian , Shen Wenyun , Cram Dustin , Fowler D. Brian , Wei Yangdou , Zou Jitao 
Published: January 2015

AbstractGlycerolipid biosynthesis in plants proceeds through two major pathways compartmentalized in the chloroplast and the endoplasmic reticulum (ER). The involvement of glycerolipid pathway interactions in modulating membrane desaturation under temperature stress has been suggested but not fully explored. We profiled glycerolipid changes as well as transcript dynamics under suboptimal temperature conditions in three plant species that are distinctively different in the mode of lipid pathway interactions. In Arabidopsis thaliana, a 16:3 plant, the chloroplast pathway is upregulated in response to low temperature, whereas high temperature promotes the eukaryotic pathway. Operating under a similar mechanistic framework, Atriplex lentiformis at high temperature drastically increases the contribution of the eukaryotic pathway and correspondingly suppresses the prokaryotic pathway, resulting in the switch of lipid profile from 16:3 to 18:3. In wheat (Triticum aestivum), an 18:3 plant, low temperature also influences the channeling of glycerolipids from the ER to chloroplast. Evidence of differential trafficking of diacylglycerol moieties from the ER to chloroplast was uncovered in three plant species as another layer of metabolic adaptation under temperature stress. We propose a model that highlights the predominance and prevalence of lipid pathway interactions in temperature-induced lipid compositional changes.
I worship, so I download? Idol worship, music purchase and piracy by young consumers in Taiwan
Authors: Huang Yu-An , Lin Chad , Su Hung-Jen , Tung Mei-Lien 
Published: January 2015

Purpose– The purpose of this paper is to examine the effect of parental and peer norms on idol worship as well as the effect of idol worship on the intention to purchase and obtain the idol’s music products legally and illegally.Design/methodology/approach– A stratified, two-stage, cluster sampling procedure was applied to a list of high schools obtained from the Ministry of Education in Taiwan. A return rate of 80 per cent yielded 723 usable questionnaires, the data from which were analysed by the LISREL structural equation modelling software.Findings– The results suggest that both social worship and personal worship have a significant and positive impact on the intention to purchase music. However, personal worship has a negative impact on the intention to pirate music while social worship appears to strengthen it.Research limitations/implications– The findings suggest that idol worship is more complex than previously understood. The constructs chosen in this research should be seen only as a snapshot but other variables such as vanity trait, autonomy, romanticism or involvement are not taken into account. Future studies would benefit from inclusion of these variables and a wider geographical scope.Practical implications– The findings contain many implications to help marketing executives and planners better revise their existing marketing and communication strategies to increase their revenue.Originality/value– Existing research has tended to examine the impact of idol worship as a whole on the reduction of music piracy, but overlook the two-dimensional aspects of idol worship, hence ignoring the fact that many music firms have not properly utilised idol worship to deal with the challenges associated with music piracy. The findings broaden existing understanding about the causes of two different dimensions of idol worship and their different impacts on the intention to music piracy.