bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dampak Gadget pada Anak Usia Dini
Authors: Fauziah Fajriyati , Elan Elan , Aprily Nuraly Ma’sum 
Published: July 2024

The purpose of this study to describe the impact of gadgets for early childhood. A gadget is a small telecommunications device that has specific practical purposes and useful functions that are generally assigned to something new. Gadget users are currently very common and users range from children to the elderly. Early childhood has great potential in developing all the potential that exists within them. Talking, socializing, getting to know the environment, showing his abilities, understanding a problem and then naturally solving the problem according to the mindset of children his age who have their own perspective. The impact that occurs when a child is addicted to gadgets is that there are negative and positive impacts. This study uses a qualitative research method. The type of this research is a literature study.Tujuan penelitian ini untuk menjelaskan dampak gadget pada anak usia dini. Gadget adalah suatu alat telekomunikasi kecil yang memiliki tujuan dan fungsi praktis spesifik yang berguna yang umumnya diberikan terhadap suatu yang baru. Pengguna gadget pada saat ini sangat marak terjadi dan penggunanya mulai dari anak-anak hingga orang tua. Anak usia dini memiliki potensi besar dalam mengembangkan segala potensi yang ada di dalam dirinya. Bercakap, bersosialisasi, mengenal lingkungan, menunjukkan kemampuan dirinya, memahami suatu masalah lalu dengan alami menyelesaikan masalah tersebut sesuai dengan pola pikir anak seusianya yang memiliki cara pandang tersendiri. Dampak yang terjadi jika anak kecanduan gadget yaitu ada dampak negative dan dampak positif. Penelitian ini menggunakan Metode penelitian Kualitatif., jenis dari penelitian ini adalah studi kepustakaan.
Pengembangan Kecerdasan Linguistik Anak melalui Media Puzzle Huruf
Authors: Daulay Zharifah Zahwa , Sa’Dia Amanda Halimatus , Sit Masganti 
Published: July 2024

This study aims to explore the development of children's linguistic intelligence through the use of letter puzzle media at Hamdaniyah Kindergarten. Descriptive qualitative research methods were used to understand the experiences and perceptions of teachers and children in interaction with the media. The results showed that children demonstrated significant improvements in various aspects of linguistic intelligence, including communication skills, vocabulary, early reading, early writing, listening, and comprehension, as a result of their participation in the letter puzzle activity. In addition, positive responses from children and teachers indicated that the use of letter puzzles can be an effective method in increasing learning motivation and building children's confidence in language learning at Hamdaniyah Kindergarten.Penelitian ini bertujuan untuk mengeksplorasi pengembangan kecerdasan linguistik anak melalui penggunaan media puzzle huruf di TK Hamdaniyah. Metode penelitian kualitatif deskriptif digunakan untuk memahami pengalaman dan persepsi guru serta anak-anak dalam interaksi dengan media tersebut. Hasil penelitian menunjukkan bahwa anak-anak menunjukkan peningkatan signifikan dalam berbagai aspek kecerdasan linguistik, termasuk kemampuan berkomunikasi, kosa kata, membaca awal, menulis awal, mendengar, dan memahami, sebagai hasil dari partisipasi mereka dalam aktivitas puzzle huruf. Selain itu, respon positif dari anak-anak dan guru-guru mengindikasikan bahwa penggunaan puzzle huruf dapat menjadi metode yang efektif dalam meningkatkan motivasi belajar dan membangun rasa percaya diri anak-anak dalam pembelajaran bahasa di TK Hamdaniyah.
The myriad presentations of peripartum cardiomyopathy
Authors: Banerjee Yajnaseni , Tilve Arundhati 
Published: July 2024

Peripartum cardiomyopathy (PPCM) is an idiopathic, non-ischemic systolic type of heart failure which can present anytime from the last month of pregnancy till the end of 5th month post-partum. The incidence of PPCM in the Indian population is 1:1340 with 60% of the cases occurring post-partum. PPCM has a mortality rate of 11.7% with unpredictable sequelae ranging from worsening heart failure, cardiogenic shock, development of arrythmias to complete recovery and recurrence in subsequent pregnancies. With an idiopathic aetiology with multiple theories, PPCM remains a diagnosis of exclusion, demanding a high index of suspicion and surveillance in pregnant women. The management involves a multidisciplinary approach involving the obstetrician, cardiologist and at times the anaesthesiologist and includes various drugs like beta- blockers, diuretics, digoxin, bromocriptine. In severe cases, maternal circulatory support may also be needed. We present three cases of PPCM diagnosed in the antepartum, intrapartum and immediate post-partum periods respectively. Out of 3 patients, one delivered vaginally and two underwent emergency caesarean sections. All of patients went home post-delivery with good outcomes and were doing well after 4 weeks of delivery.
CARACTERIZACIÓN INMUNOQUÍMICA Y MOLECULAR DE LOS ALERGENOS DE BLOMIA TROPICALIS, UN ACARO CAUSANTE DE ASMA EN EL TRÓPICO
Authors: Caraballo Luis 
Published: July 2024

La mayoría de los casos de asma son de origen alérgico. Esta enfermedad es causada, en personas genéticamente susceptibles, por los alergenos de los ácaros del polvo de habitación. En el trópico, los ácaros más comunes son B. tropicalis y Dermatophagoides pteronyssinus. La importancia clínica del primero se ha descrito en la última década y gran parte de esta información se ha generado en nuestro laboratorio. Este artículo describe los procedimientos y resultados de la caracterización inmunoquímica y molecular de los alergenos de B. tropicalis, en un enfoque general que llevaría a su manipulación genética con el fin de obtener reactivos para el tratamiento de las enfermedades alérgicas.
Fragmentation as a Generational Strategy
Authors: Afanasov N.B. 
Published: July 2024

The article represents the author&#x27;s reflection on the key features of the philosophical generation that was formed in the Russian-speaking space in the 10s of the 20th century. The author believes that a relevant theoretical lens for considering the specifics that distinguish young people who began their journey in philosophy during these years could be an appeal to the sociological typology of generations. According to the authoritative sociologist Vadim Radaev, the designated philosophical generation belongs to the “millennials.” The key characteristics that distinguish these young people include isolation, passion for gadgets and everyday digitalization, lack of desire to build a career, and inability to integrate into large hierarchical structures. Based on his personal experience, presented in the form of brief notes on key topics shaping the intellectual generation – magazines, people, books, places – the author invites the reader to consider some circumstances of his personal intellectual biography that could serve as evidence confirming the hypothesis. Without hoping to be able to “capture” the essence of his generation, the author hopes that his memories may be useful for subsequent comparative analysis.
Herramientas de modelaje y optimización en el ámbito de la investigación operativa
Authors: Burbano Pantoja Víctor Miguel Ángel , Valdivieso Miranda Margoth Adriana 
Published: July 2024

Históricamente, los seres humanos han observado y buscado diferentes formas de representar y solucionar los problemas que se han suscitado en su entorno natural y social. Para esto han utilizado herramientas de modelaje como las matemáticas en general, la geometría, los métodos ingenieriles, la experimentación en el campo de las ciencias naturales y la hermenéutica en las ciencias sociales, entre otros. Durante los dos últimos siglos, la sociedad ha experimentado avances acelerados en todos los campos del saber, en la producción de bienes y servicios y en actividades investigativas. Cada vez se requieren herramientas más sofisticadas para optimizar los procesos administrativos, productivos, académicos e investigativos, como en el caso de las técnicas asociadas con la investigación operativa, la teoría de sistemas, las TIC y la inteligencia artificial, solo por mencionar algunas.En esta obra se abordan algunas herramientas de modelaje y optimización en el ámbito de la investigación operativa, destinadas a contribuir a la formación del estudiantado universitario y a potenciar sus competencias profesionales desde una mirada sistémica y cuantitativa. Mediante la transposición didáctica se han generado distintas situaciones de aprendizaje, para que el lector pueda acrecentar sus conocimientos sobre tópicos de optimización con programación lineal como el método gráfico, simplex, dual, la asignación de actividades o la teoría de redes y de las decisiones, entre otros.
Sexual Exploitation in Marriage Tourism: Justice and Legal Protection for Victims in Cianjur and Jember
Authors: Faisol Muhammad , Saadah Sri Lumatus , Safira Martha Eri , Mufidah Lailatul 
Published: July 2024

This article aims to provide recommendations for establishing regional regulations related to tourist marriage, the imposition of strict sanctions, and efforts to protect victims. The urgency of this research is because, in several tourist areas, there has been a practice of contract marriage involving women and children with tourists for years. This research uses descriptive-qualitative data analysis with a case study approach. In contrast, data collection techniques are done through interviews and a literature review of online source data. Based on the results of the research, it was found that contract marriage cases in the Puncak Bogor area and the Jember area are one type of sexual trafficking with child victims involving marriage brokers, parents, and tourists. This marriage is motivated by economic factors to save themselves and their families from poverty. Victims are primarily virgin girls aged 14-18 years who are married off on a transactional basis in exchange for half of the promised dowry. In practice, marriages are conducted are not registered. The local government in Jember has passed a local regulation on protecting women and children, while in Cianjur a district head regulation on the prohibition of contract marriages was passed. Socialization from the Religious Affairs Office and local government is still done in tourist areas. However, some contract marriage practices can still be found because women do not feel they are victims of sexual trafficking. This research provides a basis for local government policy towards handling and minimizing the practice of contract marriage.
Heterogeneity of thymic output in elderly and its association with sex and smoking
Authors: Longhi Paula , Sandhar Balraj , Vyas Vishal , Harding Daniel , Ragazzini Roberta , Bonfanti Paola , Marelli-Berg Federica , Bell Christopher , Chain Benny 
Published: July 2024

Abstract

Thymic involution is an age-related process that results in reduced T cell production and impaired adaptive immunity. However, it remains uncertain the extent of thymic activity later in life and how this contributes to immunological ageing. Here, we identified thymic tissue within mediastinal adipose locations in aged individuals and confirmed its functional capacity through multi-omics analysis. Percentage of CD31+ CD4+ T cells correlated positively with thymic tissue presence. Thymic output in elderly showed a high degree of heterogeneity was modulated by gender and smoking history. Thymus activity was associated with a diverse TCR repertoire, unique transcriptomic profile, and distinct epigenetic signature. Adipose tissue inflammation was found to be independent of thymic activity but associated with the presence of circulating T cells with an immunosenescent phenotype. Further analysis revealed functional and phenotypic heterogeneity within distinct naïve CD4 T cell subsets, which are influenced by thymic activity.
A Novel Approach for Prediction of Rock Brittleness Based on Stacking integrated algorithm
Authors: Jia Jing , Li Diquan , Zhang Ziyi , Sun Pinghe , Fan Qinghu , Han Cao 
Published: July 2024

Abstract

The significance of rock brittleness is well-recognized in the fields of geotechnical engineering and energy exploration. To enhance the predictive precision of rock brittleness, this paper proposes a Stacking integrated algorithm. This algorithm synergistically combines various meta models and foundational models, utilizing a suite of nine algorithm modes: Gaussian Process Regression, Support Vector Machine, Backpropagation Neural network, Extreme Learning Machine network, Decision Tree, Random Forest, Extreme Gradient Boosting, Lasso Regression, and Ridge Regression. Furthermore, Tuna and Bayesian optimization algorithms are utilized to refine the model’s performance. Additionally, a new diversity index, k, based on the ratio of correlation coefficients, has been introduced to facilitate the optimal selection of base models for the Stacking integrated algorithm. The predictive accuracy of the Stacking integrated model, as determined by the proposed diversity index k, surpasses that of the finest individual base model and outperforms other sets of five integrated base models with an equivalent number of components. This underscores the efficacy of the diversity index k in guiding the selection of appropriate base models for the stacking process. The most effective model for predicting rock brittleness incorporates the Extreme Learning Machine network, Decision Tree, Random Forest and Extreme Gradient Boosting. This ensemble model demonstrates superior accuracy over the single best model, the Decision Tree, by reducing the average brittleness prediction error rate by 0.3745 and elevating the determination coefficient (R2) value from 0.9118 to 0. 9629.When compared with the Particle Swarm Optimization model, this composite model achieves an increase of 0.1498 in R2.
Exogenous dsRNA-Mediated Control of Rice Blast Fungus Involves Sequence-Specific RNAi and Sequence-Unspecific Fungal Stress Responses
Authors: Ladera-Carmona Maria , Zheng Ying , Moorlach Benjamin , Jakobs-Schönwandt Desiree , Patel Anant , Pastacaldi Chiara , Jacob Stefan , Sede Ana , Heinlein Manfred , Poranen Minna , Kogel Karl-Heinz 
Published: July 2024

Abstract

In vertebrates and plants, double-stranded (ds)RNA plays crucial roles as a pathogen-associated molecular pattern (PAMP) and as a mediator of RNA interference (RNAi). However, our understanding of fungal responses to dsRNA remains limited. Here, we demonstrate that Magnaporthe oryzae (Mo), a globally significant crop pathogen, actively internalizes exogenous dsRNA across a broad size range of 21 to about 3000 bp. Treatment of Mo conidia with dsRNA, irrespective of size or sequence, induces aberrant germ tube elongation. Additionally, application of dsRNA to Brachypodium distachyon leaves suppresses disease progression upon Mo infection. Intriguingly, dsRNA elicits canonical stress pathways in Mo, as evidenced by nuclear accumulation of the stress marker mitogen-activated protein kinase Hog1p and the production of reactive oxygen species. However, these sequence-nonspecific effects are transient, while sequence-specific RNAi activity predominates in a preventive intervention scenario, when a time interval of several days between dsRNA application and fungal inoculation is maintained, and dsRNA is stabilized in novel alginate-chitosan nanoparticles. Overall, our data show that the effects of dsRNA on fungi and the diseases they cause can be multifaceted and complex, which has implications for the development and application of dsRNA pesticides in agricultural practice.
High versus low IMA ligation: lymph node yield and anastomosis feasibility impact
Authors: Cheng Daqing , Zhang Yunpeng , Lin Qunjun , Xu Ming , Wang Jue , Sun Peng , Han Bo 
Published: July 2024

Abstract

This study investigated the postoperative complications and pathological outcomes of patients undergoing high and low ligation of the inferior mesenteric artery. After ligation of the inferior mesenteric artery, indocyanine green (ICG) angiography staining technology was used to determine the blood supply location and complete anastomosis instead of traditional empirical judgment. We analyzed 380 patients with rectal or sigmoid colon cancer. The results showed no significant differences in gender, age, body mass index, diabetes, other comorbidities, ASA classification, estimated intraoperative blood loss, preoperative albumin levels, tumor pathological type, and postoperative hospital stay. However, the high ligation group had higher preoperative CEA levels, a lower proportion of hypertension, longer surgical duration, later T and N stages, higher hospitalization costs, and a higher proportion of ostomy creation. There was no difference in the incidence of deep space infection and fistulas between the two groups, and the overall complication rate was also similar. More lymph nodes were obtained in the high ligation group. In summary, ICG angiography can effectively ensure the blood supply to the anastomotic site, reduce the possibility of anastomotic fistula caused by insufficient blood supply to the anastomotic site, and high ligation is associated with more lymph node dissection. These findings highlight the objective assessment capabilities of ICG in determining blood supply to the anastomotic intestinal tract and the advantages of high ligation in terms of thorough lymph node dissection.
De novo Design of Near Infrared Fluorescent Proteins
Authors: Baker David , Xu Chunfu , Liu Yulai , Arús Bernardo , Mishra Kanuj , Luciano Michael , Bandi Venu , Kumar Akaash , Guo Ziyu , Bick Matthew , Xu Miaomiao , Zhang Kun , Lingg Jakob , Bae Jessica , Kang Alex , Gerben Stacey , Bera Asim , Vaughan Joshua , Manton James , Derivery Emmanuel , Schnermann Martin , Stiel Andre , Bruns Oliver , Guan Yun 
Published: July 2024

Abstract

Fluorescent proteins have revolutionized the field of molecular imaging, enabling the visualization of diverse biological processes. Biological imaging in the near-infrared (NIR, 800-1000 nm) and shortwave infrared (SWIR, 1000-2000 nm) ranges confers a number of photophysical advantages, but remains a challenge in practice due to the dearth of suitable fluorescent proteins for these optical windows. To address this limitation, we sought to develop a general approach integrating computational protein design with organic synthesis for creating long-wavelength fluorescent proteins from scratch. We used this approach to design a new class of proteins that specifically bind to synthetic merocyanine dyes, forming Schiff base covalent linkages, which when protonated activate fluorescence with large redshifts in both excitation and emission wavelengths. Our de novo designed far-red fluorescent protein MC7BP34 exhibited a brightness greater than that of existing protein probes in a similar wavelength range. The de novo designed NIR fluorescent protein MC9BP81 with excitation at 892 nm and emission extending into the SWIR range demonstrated higher contrast and imaging sensitivity in vivo than the previously developed iRFP720 (excitation 672 nm) owing to the reduced tissue autofluorescence at longer wavelengths. Our results are a substantial step towards genetically encodable probes in the SWIR region, and our approach lays the groundwork for the development of NIR biosensors for specific biological applications.
High-Frequency Radar observation of strong and contrasted currents: the Alderney race paradigm
Authors: Dumas Dylan , Bennis Anne-Claire , Guérin Charles-Antoine , Lopez Guiomar , Benoit Laurent 
Published: July 2024

Abstract

The Alderney Race has been identified as a future site for the development of tidal energy, due to its bidirectional strong current reaching 5 m/s during spring tides. This hydrodynamics is very difficult to measure by in-situ or remote sensing means. High-frequency coastal radars can provide a synoptic and near-real-time view of such a complex circulation, but the classical processing algorithms are not adapted to the extreme situation of strongly sheared currents. We propose an improved high-resolution direction-finding technique for the azimuthal processing of such radar data. It uses phased-array systems and combines the advantages of the usual beam-forming technique to eliminate many problems related to the distortion of Doppler spectra by extreme currents. The method is evaluated with a unique data set of radar measurements at two radar frequencies (13 and 24.5MHz) and three spatial resolutions (200, 750, and 1500 m). The radar-based surface currents are analyzed in the light of a high-resolution numerical model and also compared with in-situ measurements. While high azimuthal resolution can be achieved in this way, it is shown that the typical range resolutions of 750 and 1500 m are insufficient to account for the strong spatial variations of the surface current at some specific times and locations.
Integrating multi-hazard, socio-physical information in a holistic index for decision making on disaster risk reduction
Authors: Tocchi Gabriella , Cremen Gemma , Galasso Carmine , Polese Maria 
Published: July 2024

Abstract

Effective disaster-risk management requires holistic risk-modelling approaches, which: (1) capture the effects of multiple (natural) hazards on the system/community of interest; and (2) account for social vulnerability factors that influence how different sectors within the community experience, respond to and cope with these effects. We propose a straightforward multi-risk index that integrates both of these crucial considerations. The index represents a combination of indicators for individual risks of interest. It appropriately accounts for uncertainties in the underlying dimensions of risk, relying on probabilistic distributions of hazard, physical and social vulnerability, and population exposure information. Furthermore, these dimensions are weighted in the index calculation to explicitly reflect variable stakeholder priorities on associated matters (e.g., policymaking). We demonstrate the index for earthquake and flood risk across the entire country of Italy (at the resolution of municipalities), using easily accessible open data. The proposed index identifies hotspots across the country that should be prioritised for disaster risk reduction actions. Sensitivity analyses of the applied weights reveal how these hotspots can change as a function of stakeholder preferences and/or variations in the emphasis placed on different types of hazards, ultimately underlining the importance of accounting for accurate stakeholder feedback and adopting a multi-layered view of risk in disaster-related decision making. A prominent advantage of the proposed index is that it is relatively simple and could be easily adopted for practical multi-risk decision support across any other national or transnational context of interest.
Automatic Generation of a Fault Database in Electrical Power Distribution Networks Using ATPDraw/ATP
Authors: Abreu Francisco C. M. , Machado Vinícius P. , Aumeida Aryfrance R. , Rabêlo Ricardo de A. L. , Filho José C. C. L. Silva 
Published: July 2024

Abstract

Fault location in electric power distribution networks is essential to improve the continuity and quality of the power supply. Among the fault location methods, those based on artificial intelligence are less sensitive to noise in the input data and considerably more accurate compared to other methods. However, these methods require a substantial amount of training data. Thus, this study proposes a method to automatically generate a fault database for faults in electric power distribution networks using ATPDraw/ATP software and the Python programming language. The IEEE34 bus system was used to validate the proposed method, resulting in a fault database, made available to the scientific community, with 6700 files containing different types of faults, incidence angles, and fault resistances.