bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma
Authors: Jiang He‐Jiun , Hung Wei‐Wen , Hsiao Pi‐Jung 
Published: September 2013

AbstractAcromegaly is always complicated with comorbidities and increased mortality. The disease activity and mortality outcomes are highly correlated to the level of growth hormone and insulin‐like growth factor 1. A variety of clinical manifestations of acromegaly have been reported. We present a unique case where a 49‐year‐old male was diagnosed with acromegaly with a first manifestation as an episode of diabetic ketoacidosis. Because he refused any suggestion of treatment, a recurrent episode of diabetic ketoacidosis with pituitary apoplexy occurred. A huge B‐cell lymphoma displaying as a huge facial mass followed within 1 year of the diagnosis of acromegaly. Death from advanced cancer ensued 3 years later. This clinical experience strongly reinforces the urgency of controlling growth hormone and insulin‐like growth factor 1 as soon as possible once acromegaly is diagnosed.
Relationship between anthropometric indicators and cognitive performance in Southeast Asian school-aged children
Authors: Sandjaja  , Poh Bee Koon , Rojroonwasinkul Nipa , Le Nyugen Bao Khanh , Budiman Basuki , Ng Lai Oon , Soonthorndhada Kusol , Xuyen Hoang Thi , Deurenberg Paul , Parikh Panam 
Published: September 2013

Nutrition is an important factor in mental development and, as a consequence, in cognitive performance. Malnutrition is reflected in children's weight, height and BMI curves. The present cross-sectional study aimed to evaluate the association between anthropometric indices and cognitive performance in 6746 school-aged children (aged 6–12 years) of four Southeast Asian countries: Indonesia; Malaysia; Thailand; Vietnam. Cognitive performance (non-verbal intelligence quotient (IQ)) was measured using Raven's Progressive Matrices test or Test of Non-Verbal Intelligence, third edition (TONI-3). Height-for-age z-scores (HAZ), weight-for-age z-scores (WAZ) and BMI-for-age z-scores (BAZ) were used as anthropometric nutritional status indices. Data were weighted using age, sex and urban/rural weight factors to resemble the total primary school-aged population per country. Overall, 21 % of the children in the four countries were underweight and 19 % were stunted. Children with low WAZ were 3·5 times more likely to have a non-verbal IQ < 89 (OR 3·53 and 95 % CI 3·52, 3·54). The chance of having a non-verbal IQ < 89 was also doubled with low BAZ and HAZ. In contrast, except for severe obesity, the relationship between high BAZ and IQ was less clear and differed per country. The odds of having non-verbal IQ levels < 89 also increased with severe obesity. In conclusion, undernourishment and non-verbal IQ are significantly associated in 6–12-year-old children. Effective strategies to improve nutrition in preschoolers and school-aged children can have a pronounced effect on cognition and, in the longer term, help in positively contributing to individual and national development.
Belgian substages as a basis for an international chronostratigraphic division of the Tournaisian and Viséan
Authors: POTY EDOUARD , ARETZ MARKUS , HANCE LUC 
Published: September 2013

AbstractThe Tournaisian and Viséan were formerly considered as series and in Belgium were divided into two (Hastarian and Ivorian) and three stages (Moliniacian, Livian and Warnantian), which are now considered as substages. The Belgian substages are based on conodonts and foraminifers, and incidentally on rugose corals, and are described here. Their boundaries, biostratigraphy and sequence stratigraphy are well detailed and clearly defined. The base of the Hastarian (lower Tournaisian) corresponds to the base of the Tournaisian (base of Carboniferous); the base of the Ivorian (upper Tournaisian) corresponds to the appearance of the conodontPolygnathus communis carina, a little above the lastSiphonodella; the base of the Moliniacian (lower Viséan) corresponds to the base of the Viséan stage defined by the first occurrence of the foraminiferEoparastaffella simplex; the Livian (middle Viséan) corresponds to the foraminiferal MFZ12 Zone and is marked by the appearance ofKoskinotextulariaandPojarkovella nibelis; the base of the Warnantian (upper Viséan) is marked by the appearance ofNeoarchaediscus,Vissariotaxis,Planospirodiscus, andPalaeotextulariawith a bilaminar wall, the index taxa of the MFZ13-NeoarchaediscusZone. The up-to-date chronostratigraphic subdivision of the Tournaisian and Viséan is not limited to Belgium and the surrounding areas. It can be applied through Eurasia as far as South China. The Belgian units could therefore be the basis for a future international division of the Tournaisian into two parts (Hastarian and Ivorian) and of the Viséan into three parts (Moliniacian, Livian and Warnantian), corresponding to time intervals ofc.5–8 Ma.
Behavioural changes in the flour beetleTribolium confusuminfected with the spirurid nematodeProtospirura muricola
Authors: Schutgens M. , Cook B. , Gilbert F. , Behnke J.M. 
Published: September 2013

AbstractWe examined changes to the behaviour of flour beetles,Tribolium confusum, infected with the rodent stomach worm, the spiruridProtospirura muricola, in the context of the ‘Behavioural Manipulation Hypothesis’.Trobolium confusuminfected with the third-stage infective larvae ofP. muricolashowed consistently altered patterns of behaviour. Relative to uninfected beetles, over a measured time period, beetles infected withP. muricolawere likely to move over a shorter distance, when moving their speed of movement was slower, they were more likely to stay in the illuminated area of their environment, more likely to emerge from darkened areas into the illuminated areas, and their longevity was significantly shortened. The changes in behaviour, as reflected in effects on speed of movement, were only evident among beetles that actually harboured infective cysts and not among those carrying younger infections when the larvae within their haemocoels would have been at an earlier stage of development and not yet capable of infecting the definitive murine hosts. We discuss whether these changes would have made the beetles more susceptible to predation by rodents, and specifically by the omnivorous eastern spiny mouse,Acomys dimidiatus, the natural definitive host of this parasite in Egypt, from where theP. muricolaisolate originated, and whether they support the Behavioural Manipulation Hypothesis or reflect parasite-induced pathology.
Parasites of the grouper fishEpinephelus coioides(Serranidae) as potential environmental indicators in Indonesian coastal ecosystems
Authors: Kleinertz S. , Palm H.W. 
Published: September 2013

AbstractA total of 195Epinephelus coioides(Hamilton, 1822) were studied for fish parasites from Javanese (Segara Anakan lagoon) and Balinese waters. Up to 25 different parasite species belonging to the following taxa: one Ciliata, one Microsporea, five Digenea, one Monogenea, four Cestoda, four Nematoda, one Acanthocephala, one Hirudinea and seven Crustacea were identified with four new host and locality records. The dominant parasites included the monogeneanPseudorhabdosynochus lantauensis(53.3–97.1%), the nematodeSpirophilometra endangae(23.3–42.9%), the digeneanDidymodiclinussp. (2.9–40.0%), the nematodesPhilometrasp. (22.6–34.3%) andRaphidascarissp. (2.9–28.6%), and the isopodAlcironasp. (6.7–31.4%). Regional differences forE. coioideswere found in terms of endoparasite diversity, total diversity according to Shannon–Wiener, Simpson index and Evenness. A comparison with published data from Sumatera revealed highest endoparasite diversity (Shannon–Wiener: 1.86/1.67–2.04) and lowest ectoparasite/endoparasite ratio (0.73/0.57–0.88) off the Balinese coast, followed by Lampung Bay, Sumatera (1.84; 0.67), off the coast of Segara Anakan lagoon (1.71; 0.71), and in the lagoon (0.30/0.19–0.66; 0.85/0.67–1.00). The presented data demonstrate the natural range of these parameters and parasite prevalences according to habitat and region, allowing adjustment of the scale that has been used in the visual integration of the parasite parameters into a star graph. The parasite fauna ofE. coioidesin Segara Anakan lagoon ‘improved’ from 2004 until 2008/09, possibly related to earlier oil spill events in 2002 and 2004. The use of grouper fish parasites as an early warning system for environmental change in Indonesian coastal ecosystems is discussed.
Laser irradiation of thin films: Effect of energy transformation
Authors: Povarnitsyn Mikhail E. , Andreev Nikolay E. , Levashov Pavel R. , Khishchenko Konstantin V. , Kim Dmitry A. , Novikov Vladimir G. , Rosmej Olga N. 
Published: September 2013

AbstractThe irradiation of thin films by intensive subpicosecond laser pulses with nanosecond prepulse is accompanied by a number of various physical processes. The laser beam transmissions through the film as well as the re-emission flux on both sides of the film plasma have been evaluated by simulation for Al and CH2 materials. It has been demonstrated that the thickness of the film can be chosen to cut off the long nanosecond prepulse whereas the main pulse is transmitted through the plasma. Thus, thin films can be useful for the laser contrast improvement in experiments with different targets.Nevertheless, the laser energy transformation into the soft X-ray radiation on the back side of the shielding film plasma can reach up to 7% of the incident intensity for the Al film and result in strong preheating of the target. At the same time the re-emission flux produced by a CH2 film is an order lower than that in the case of Al film. The shielding of an Ag bulk target by Al and CH2 films is simulated and discussed.
Synthesis and X-ray powder diffraction data of cis-4-(4-methoxyphenyl)-3-methyl-6-nitro-2-phenyl-1,2,3,4-tetrahydroquinoline
Authors: Macías M.A. , Henao J.A. , Bohórquez Arnold R. Romero , Kouznetsov Vladimir V. 
Published: September 2013

The 2,4-diaryl 1,2,3,4-tetrahydroquinoline derivative (1), described in the title (Chemical formula: C23H22N2O3), was synthesized via the “one-pot” three-component imino Diels–Alder reaction catalyzed by Cu(OTf)2. Molecular characterization was performed by 1H and 13C NMR, Fourier transform-infrared, and gas chromatography-mass spectrometry. The X-ray powder diffraction pattern for the title compound was analyzed and found to be crystallized in an orthorhombic system with space group P212121 (No. 19) and refined unit-cell parameters a = 8.6415(8) Å, b = 12.679(2) Å, c = 17.601(2) Å, and V = 1928.4(2) Å3.
Nuclear and charge density distributions in ferroelectric PbTiO3: maximum entropy method analysis of neutron and X-ray diffraction data
Authors: Zhu Jinlong , Han Wei , Zhang Jianzhong , Xu Hongwu , Vogel Sven C. , Jin Changqing , Izumi Fujio , Momma Koichi , Kawamura Yukihiko , Zhao Yusheng 
Published: September 2013

We conducted in-situ high-temperature neutron and X-ray diffraction studies on tetragonal PbTiO3. Using a combination of Rietveld analysis and Maximum Entropy Method, the nuclear and charge density distributions were determined as a function of temperature up to 460 °C. The ionic states obtained from charge density distributions reveal that the covalency of Pb–O2 bonds gradually weakens with increasing temperature. The spontaneous polarizations calculated from the contributions of ionic state, ionic displacement, and nuclear polarization, are in good agreement with the experimental measurements. This method provides an effective approach to determine spontaneous polarizations in multiferroics with high-current leakage and low resistance.
Barcelona's water supply, 1867–1967: the transition to a modern system
Authors: GUARDIA MANEL , ROSSELLÓ MARIBEL , GARRIGA SERGI 
Published: September 2013

ABSTRACTThe development of modern water supply systems has varied widely in terms of speed, paths and results, and each supply system has been strongly conditioned by its spatial, socio-economic and cultural context. Barcelona provides a useful illustration of how such a modern system came into being in a particularly dynamic southern European setting. Despite being Spain's leading industrial centre, the driving force behind the introduction of its new water supply system did not come from an industrial imperative but rather from the city's expansion plan, approved in 1859, which gave rise to a proliferation of private initiatives. Later, decisive changes around the turn of the twentieth century led to a concentration of water companies, sewer renewal projects and the entry of water into the domestic sphere, and the extension of the water supply to people's homes. The development of a modern water supply system in Barcelona, however, required a period of a hundred years – from 1867, when the first steam-powered pumping station was built, to 1967, when the water from the Ter River transfer reached the city, allowing new consumption patterns to spread rapidly.
Cardiovascular health among Philadelphia adolescents: analysis of youth risk behaviour data, 2011
Authors: Lenhart Clare M. , Manjelievskaia Janna , Echeverri Andrea , Patterson Freda 
Published: September 2013

AbstractImproving population-level cardiovascular health is a public health priority. Guided by the American Heart Association's metrics for ideal heart health, we examined the prevalence of behavioural heart health indicators using a representative sample of urban adolescents. Less than 1% (0.6%) of the sample had ideal heart health. The alarmingly low percentage of ideal behavioural heart health suggests that primary prevention approaches to address cardiovascular health in youth are warranted.
Catheter ablation of idiopathic ventricular tachycardia in children using the EnSite NavX system with/without fluoroscopy
Authors: Ozyilmaz Isa , Ergul Yakup , Akdeniz Celal , Ozturk Erkut , Tanidir Ibrahim C. , Tuzcu Volkan 
Published: September 2013

AbstractObjectivesCurative therapy of idiopathic ventricular tachycardia remains a challenge in interventional electrophysiology. The aim of this study was to demonstrate the utility of an EnSite NavX system in the catheter ablation of idiopathic ventricular tachycardia in children.Patients and methodsIn all, 17 children with idiopathic ventricular tachycardia underwent electrophysiological studies using the EnSite NavX system guidance.ResultsThe mean patient age was 13 ± 2.4 years (range: 7.8–17.9) and the mean patient weight was 52.3 ± 11.9 kg (range: 32–75). The origin of ventricular tachycardia was in the right ventricular outflow tract in nine patients, in the left ventricle in six, near the bundle of His/right bundle branch in one, and in the left aortic cusp in one. The mean procedure and fluoroscopy times were 169.3 ± 43.2 minutes and 8 ± 10.8 minutes, respectively. No fluoroscopy was used in six patients. The mean radiation exposure was 33.1 ± 56.4 mGy. Acute success was achieved in 14 patients (82%). The focus of ventricular tachycardia was epicardial in two failed procedures. During a mean follow-up of 8.5 ± 7.6 months, ventricular tachycardia recurred in three patients, two of whom underwent a second procedure. Except for one patient who developed transient right bundle branch block, no complications were seen.ConclusionCatheter ablation of idiopathic ventricular tachycardia in children can be performed safely and effectively with low fluoroscopy exposure using the EnSite NavX system.
Nanolithography on Graphene by Using Scanning Tunneling Microscopy in a Methanol Environment
Authors: Kim Chulsu , Park Joonkyu , Seo Yongho , Ahn Jinho , Park In-Sung 
Published: September 2013

AbstractSince it was discovered in 2004, graphene has attracted enormous attention as an emerging material for future devices, but it has been found that conventional lithographic processes based on polymer resist degrade its intrinsic performance. Recently, our group studied a resist-free scanning tunneling microscopy-based lithography in various atmospheres by injecting volatile liquids into a chamber. In this study, multilayer graphene was scanned and etched by controlling bias voltage under methanol pressure. We focused on improving patterning results in terms of depth and line width, while the previous study was performed to find an optimum gas environment for patterning on a graphite surface. Specifically, we report patterning outputs depending on conditions of voltage, current, and pressure. The optimum conditions for methanol environment etching were a gas pressure in the range of 41–50 torr, a −4 V tip bias, and a 2 nA tunneling current.
The role of the keyworker in breaking down professional culture barriers to providing high-quality palliative care: a literature review
Authors: Feuz Carina 
Published: September 2013

AbstractBackgroundPalliative cancer care is by definition multi-professional in nature. An interdisciplinary approach to disease management emphasising continuity of care results in increased quality of life for patients and families. Complex disease management demands the provision of a full spectrum of high-quality care; requiring both specialist and generalist services. Appointed keyworkers are knowledgeable about patient preferences enabling effective coordination of care and promotes collaborative team-working. The need for diversity in the provision of palliative care is recommended but can challenge effective interdisciplinary collaboration by creating tension and limiting the interdisciplinary team (IDT) from reaching its full potential resulting in adverse outcomes.PurposeThe purpose of this paper is to review the literature available regarding how IDTs and keyworkers influence high-quality palliative care; evaluate how professional culture barriers can influence team collaboration; discuss the keyworker role in minimising these barriers and clinical implications.MethodologyA review of the English literature from 2003 to 2013 was performed using the databases PubMed (NML), OVID Medline and Google Scholar.Results and conclusionKeyworkers can help overcome professional culture barriers that result from ineffective team communication. Facilitating improved communication regarding professional roles fosters mutual understanding among team members. The dissemination of relevant and timely information minimises fragmentation, prompting team decision-making and promotes continuity of high-quality palliative care.
Vision and air flow combine to streamline flying honeybees
Authors: Taylor Gavin J. , Luu Tien , Ball David , Srinivasan Mandyam V. 
Published: September 2013

AbstractInsects face the challenge of integrating multi-sensory information to control their flight. Here we study a ‘streamlining’ response in honeybees, whereby honeybees raise their abdomen to reduce drag. We find that this response, which was recently reported to be mediated by optic flow, is also strongly modulated by the presence of air flow simulating a head wind. The Johnston's organs in the antennae were found to play a role in the measurement of the air speed that is used to control the streamlining response. The response to a combination of visual motion and wind is complex and can be explained by a model that incorporates a non-linear combination of the two stimuli. The use of visual and mechanosensory cues increases the strength of the streamlining response when the stimuli are present concurrently. We propose this multisensory integration will make the response more robust to transient disturbances in either modality.
Mechanism for activation of mutated epidermal growth factor receptors in lung cancer
Authors: Red Brewer Monica , Yun Cai-Hong , Lai Darson , Lemmon Mark A. , Eck Michael J. , Pao William 
Published: September 2013

Significance
This is a unique report of receptor tyrosine kinase (RTK) “superacceptor” activity in which mutated EGFRs associated with lung cancer preferentially adopt the “acceptor” or “receiver” position in the presence of WT epidermal growth factor receptor (EGFR) or ErbB-2. The mechanism of superacceptor activity is defined by biochemical reconstitution data in combination with the first crystal structure of the L834R/T766M (L858R/T790M in alternate numbering) mutant EGFR kinase asymmetric dimer in an active conformation. The data imply that mutant/wild-type interactions play a key role in tumorigenesis as well as sensitivity of cells to various EGFR tyrosine kinase inhibitors, which could be therapeutically important. Notably, none of the previous studies involving mutated EGFR have studied the contribution of WT EGFRs in heterogeneous cell populations, although in nearly all instances wild-type EGFR alleles are preserved within EGFR mutant tumor cells.
Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination
Authors: Misaghi Shahram , Senger Kate , Sai Tao , Qu Yan , Sun Yonglian , Hamidzadeh Kajal , Nguyen Allen , Jin Zhaoyu , Zhou Meijuan , Yan Donghong , Lin Wei Yu , Lin Zhonghua , Lorenzo Maria N. , Sebrell Andrew , Ding Jiabing , Xu Min , Caplazi Patrick , Austin Cary D. , Balazs Mercedesz , Roose-Girma Merone , DeForge Laura , Warming Søren , Lee Wyne P. , Dixit Vishva M. , Zarrin Ali A. 
Published: September 2013

SignificanceSwitch (S) regions are repetitive DNA sequences. During an immune response, one of several S regions recombine with a donor switch (Sμ) that is constitutively “on,” resulting in the production of antibodies with new functions. Donor Sμ is large and very repeat-rich, while another switch, Sε, is less than half its size with a low density of repeats. We replaced Sε with Sμ in mice. These mice switch to Sε more effectively and produce high levels of IgE antibodies implicated in asthma, making this a useful model to study disease. In addition, placing Sμ outside of its native context revealed insights into how switches work.
Broad-scale predictability of carbohydrates and exopolymers in Antarctic and Arctic sea ice
Authors: Underwood Graham J. C. , Aslam Shazia N. , Michel Christine , Niemi Andrea , Norman Louiza , Meiners Klaus M. , Laybourn-Parry Johanna , Paterson Harriet , Thomas David N. 
Published: September 2013

Significance
Many marine microalgae and bacteria secrete polysaccharide gels (exopolymers) in response to environmental stresses, such as the freezing temperatures and salt concentrations that organisms experience when in sea ice. This study of sea ice cores from both the Antarctic and Arctic identified compelling relationships between ice thickness and salinity, algal biomass, and the concentration of polysaccharides in the ice. Knowing the first three parameters, we were able to predict the polysaccharide concentrations of the ice. This predictability is the first step in estimating the importance of such secretions to the organic carbon content of the millions of square kilometers of the ice-covered Arctic and Southern Oceans.
Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter
Authors: Tsao Hsiao-Wei , Tai Tzong-Shyuan , Tseng William , Chang Hui-Hsin , Grenningloh Roland , Miaw Shi-Chuen , Ho I-Cheng 
Published: September 2013

Significance
IL-2 plays critical roles in many immune responses. However, its transcriptional regulation is still not fully understood. Data described in this paper demonstrate that the transcriptional factor E26 transformation-specific sequence 1 (Ets-1) promotes the expression of IL-2 by nuclear factor of activated T-cells (NFAT)-dependent mechanisms. Nuclear Ets-1 synergizes with NFAT in the transcription of IL-2. Ets-1 is also translocated to the cytoplasm in response to calcium-induced signals and facilitates the release of NFAT from noncoding RNA repressor of NFAT complex, which traps NFAT in the cytoplasm. This paper not only advances our understanding of the transcriptional regulation of IL-2 but also depicts a unique mechanism of action of Ets-1.