bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary intake of vitamin D during adolescence and risk of adult‐onset systemic lupus erythematosus and rheumatoid arthritis
Authors: Hiraki Linda T. , Munger Kassandra L. , Costenbader Karen H. , Karlson Elizabeth W. 
Published: November 2012

AbstractObjectiveVitamin D has immunomodulatory properties with potential etiologic implications for autoimmune diseases. The relevant exposure time during which vitamin D may influence disease risk is unknown. Our objective was to examine the relationship between reported vitamin D intake during adolescence and adult‐onset rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) incidence in prospective cohort studies of women, the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII).MethodsFood frequency questionnaires concerning high school diet completed by 73,629 NHS (1986) and 45,544 NHSII (1998) participants were used to calculate nutrient intakes during adolescence. Incident RA and SLE cases prior to 2006 (NHS) and 2007 (NHSII) were confirmed by medical record review. Cox proportional hazards models calculated relative risks and 95% confidence intervals of incident RA and SLE according to quintile cutoffs of vitamin D intake. Age‐ and calorie‐adjusted and multivariable‐adjusted (including sun exposure factors) analyses were completed. Random‐effects models were used to meta‐analyze estimates of association from the 2 cohorts.ResultsIncident RA was confirmed in 652 NHS and 148 NHSII participants and SLE was confirmed in 122 NHS and 54 NHSII participants over a mean followup time of 351 months (NHS) and 209 months (NHSII). Age‐ and calorie‐adjusted and multivariable‐adjusted models did not show significant associations between adolescent vitamin D intake and risk of adult‐onset RA or SLE.ConclusionWe did not find associations between adolescent dietary vitamin D intake and adult RA or SLE risk among NHS and NHSII women, suggesting that other time periods during the life course should be studied.
Differences in physical activity patterns in patients with spondylarthritis
Authors: Haglund Emma , Bergman Stefan , Petersson Ingemar F. , Jacobsson Lennart T. H. , Strömbeck Britta , Bremander Ann 
Published: November 2012

AbstractObjectiveTo study patient‐reported physical activity in patients with spondylarthritis (SpA) and possible differences in physical activity patterns between the SpA subtypes and sexes.MethodsIn 2009, a questionnaire including inquiries concerning physical activity was sent to patients with a SpA diagnosis (n = 3,711). The World Health Organization (WHO) global recommendations of physical activity for health requiring 150 minutes of moderate‐intensity physical activity (MI‐PA) or 75 minutes of vigorous‐intensity physical activity (VI‐PA) per week were used as recommended levels. Standardized risk ratios (RRs) were calculated by using physical activity data from the Swedish population. The association within the SpA group between sex, age, disease‐related variables, anxiety, and depression and meeting recommended levels of MI‐PA and VI‐PA (dependent variables) was studied with multivariate analysis.ResultsA total of 2,167 patients with SpA (48% men, mean ± SD age 55 ± 14 years) responded to the questionnaire. Sixty‐eight percent of the patients met the WHO recommendations, more frequently in women than in men (70% versus 66%). The recommendations were more often met in the SpA group (RR 1.09, 95% confidence interval [95% CI] 1.04–1.15) compared with the Swedish population. There was a tendency for young women to meet the WHO recommendations less often than the Swedish population (RR 0.94, 95% CI 0.63–1.25). Different factors were found to influence whether the patients were exercising with a moderate or vigorous intensity.ConclusionSeven of 10 patients with SpA met the WHO recommendations of physical activity for health, but we found sex and disease subtype differences. This information can be useful in clinical practice when coaching patients to have a healthier lifestyle.
Foot‐related health care use in patients with rheumatoid arthritis in an outpatient secondary care center for rheumatology and rehabilitation in The Netherlands: A cohort study with a maximum of fifteen years of followup
Authors: Marsman Anneke F. , Dahmen Rutger , Roorda Leo D. , van Schaardenburg Dirkjan , Dekker Joost , Britsemmer Karin , Knol Dirk L. , van der Leeden Marike 
Published: November 2012

AbstractObjectiveTo describe foot‐related health care use over time in a cohort of rheumatoid arthritis (RA) patients in an outpatient secondary care center for rheumatology and rehabilitation in The Netherlands.MethodsA total of 1,087 patients with recent‐onset RA from 1995 to September 2010 were included in the study. All foot‐related visits to the podiatrist, rehabilitation physician, orthopedic surgeon, and the multidisciplinary foot‐care clinic were registered and described. Logistic regression techniques for longitudinal data were used to analyze the course of foot‐related health care use.ResultsA total of 32.9% of patients visited a podiatrist in secondary care during the course of their disease. For most patients, a visit to the podiatrist took place during the first year after diagnosis. This was followed by a significant decrease in visits in the ensuing years. Nine percent of patients visited the rehabilitation physician with foot symptoms, with peak prevalences between year 10 and 11 and during year 14 of followup. The orthopedic surgeon was visited by 5.3% of patients with foot symptoms, with a significant increase in visits over time. The multidisciplinary foot‐care clinic was visited by 7.5% of patients. This was significantly associated with visits to the rehabilitation physician.ConclusionIn an outpatient secondary care center in The Netherlands, RA patients with foot symptoms visited the podiatrist in an early stage of the disease. When foot symptoms worsened, patients visited the rehabilitation physician, who subsequently referred patients to the multidisciplinary foot‐care clinic for therapeutic footwear. The orthopedic surgeon was the final step in the management of foot symptoms.
Patient self‐report RADAI (Rheumatoid Arthritis Disease Activity Index) joint counts on an MDHAQ (Multidimensional Health Assessment Questionnaire) in usual care of consecutive patients with rheumatic diseases other than rheumatoid arthritis
Authors: Castrejón Isabel , Yazici Yusuf , Pincus Theodore 
Published: November 2012

AbstractObjectiveTo analyze a patient self‐report joint count from the Rheumatoid Arthritis Disease Activity Index (RADAI) on a Multidimensional Health Assessment Questionnaire (MDHAQ) in a cohort of consecutive patients seen in usual rheumatology care with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), osteoarthritis (OA), psoriatic arthritis (PsA), and gout.MethodsEach patient completed an MDHAQ, which included a RADAI, at each visit in one usual care setting. In order to include a physician measure, a random visit at which there was a recorded physician global estimate was selected for each of 465 patients (174 patients with RA, 75 with SLE, 113 with OA, 53 with PsA, and 50 patients with gout). The RADAI was analyzed for total scores (range 0–48), number of involved joint groups (range 0–16), and each specific joint group, and then compared in the 5 diagnostic groups to one another and to other MDHAQ measures and the Routine Assessment of Patient Index Data 3 (RAPID3).ResultsIn patients with RA, SLE, OA, PsA, and gout, mean RADAI scores (range 0–48) were 12.4, 6.5, 10.1, 6.7, and 2.7, respectively. The mean numbers of involved joint groups (range 0–16) were 6.9, 3.8, 4.8, 4.5, and 1.7, respectively, and the median numbers were 6, 2, 4, 4, and 1, respectively. RADAI scores were correlated significantly with the physician global estimate, except in SLE, and at higher levels with the MDHAQ and RAPID3 scores in all diagnostic groups.ConclusionThe RADAI self‐report joint counts can be used to record self‐report involvement of specific joints and joint groups in patients with SLE, OA, PsA, and gout, with minimal effort on the part of the rheumatologist.
Increase of body mass index in a tight controlled methotrexate‐based strategy with prednisone in early rheumatoid arthritis: Side effect of the prednisone or better control of disease activity?
Authors: Jurgens Maud S. , Jacobs Johannes W. G. , Geenen Rinie , Bossema Ercolie R. , Bakker Marije F. , Bijlsma Johannes W. J. , van Albada‐Kuipers Iet A. , Ehrlich Johan C. , Lafeber Floris P. J. G. , Welsing Paco M. J. ,   on behalf of The Utrecht Arthritis Cohort Study Group
Published: November 2012

AbstractObjectiveTo clarify whether increase of body weight in patients with early rheumatoid arthritis (RA) upon administration of prednisone is a side effect of prednisone or a result of better control of disease activity, we examined the association of prednisone and disease activity with a subsequent change in body mass index (BMI).MethodsIn the Computer Assisted Management in Early Rheumatoid Arthritis Trial‐II, patients ages ≥18 years with early RA (disease duration <1 year and no prior use of disease‐modifying antirheumatic drugs) had been randomized to a methotrexate (MTX)–based tight control strategy with either 10 mg of prednisone (MTX + prednisone) or placebo (MTX + placebo). The MTX + prednisone group had lower disease activity, but gained more weight than the MTX + placebo group (mean ± SD 2.9 ± 4.2 kg versus 1.3 ± 5.3 kg; P = 0.03). Data from patients with monthly measurements of disease activity (Disease Activity Score in 28 joints [DAS28]) and BMI were analyzed with a longitudinal regression (mixed model) analysis with BMI as the dependent variable and treatment strategy and DAS28 as the independent variables, correcting for baseline BMI and possible confounders (sex, age, and rheumatoid factor status).ResultsThere was no independent association of glucocorticoid therapy with a change in BMI, but a lower DAS28 was associated with an increased BMI 6 months later. The association of the DAS28 with BMI was most strongly present in postmenopausal women. Clinical cutoff points showed a clear association between DAS28 level and the change in BMI 6 months later.ConclusionWeight gain during treatment with prednisone seems attributable to a reduction of disease activity and is probably, at least partly, regained weight.
Adalimumab treatment in patients with rheumatoid arthritis with renal insufficiency
Authors: Sumida Keiichi , Ubara Yoshifumi , Suwabe Tatsuya , Hayami Noriko , Hiramatsu Rikako , Hasegawa Eiko , Yamanouchi Masayuki , Hoshino Junichi , Sawa Naoki , Takaichi Kenmei 
Published: November 2012

AbstractObjectiveTo elucidate the safety of adalimumab for rheumatoid arthritis (RA) patients with renal insufficiency, including those with end‐stage renal disease undergoing hemodialysis.MethodsSixty‐five RA patients, including 2 patients undergoing hemodialysis, treated with adalimumab in our hospital from December 1, 2008 to June 30, 2011 were retrospectively analyzed. Renal function was evaluated by the estimated glomerular filtration rate (eGFR) calculated from the Cockcroft‐Gault formula at the start and end of followup after adalimumab treatment. The proportion of the patients who discontinued or switched adalimumab treatment and the change of the eGFR were compared between patients with (n = 39) and without (n = 26) renal insufficiency, defined as an eGFR <60 ml/minute/1.73 m2.ResultsThere was no significant difference between the 2 groups in the proportion of the patients who discontinued or switched adalimumab treatment (51.3% versus 50.0%; P = 0.53). The mean ± SD changes of eGFR were from 41.6 ± 13.3 to 43.4 ± 17.9 ml/minute/1.73 m2 in patients with renal insufficiency and from 83.6 ± 17.5 to 83.0 ± 16.8 ml/minute/1.73 m2 in patients without renal insufficiency, and the differences in each group were not statistically significant (P = 0.92 and P = 0.78, respectively). No severe infections or other severe adverse events were observed in either group during adalimumab treatment.ConclusionOur data indicate that adalimumab does not worsen renal function and has no serious adverse events even for RA patients with renal insufficiency, including those undergoing hemodialysis, and suggest that it could be a potential therapeutic option for them.
Racial and ethnic differences in physical activity guidelines attainment among people at high risk of or having knee osteoarthritis
Authors: Song Jing , Hochberg Marc C. , Chang Rowland W. , Hootman Jennifer M. , Manheim Larry M. , Lee Jungwha , Semanik Pamela A. , Sharma Leena , Dunlop Dorothy D. ,   for the Osteoarthritis Initiative Investigators
Published: November 2012

AbstractObjectiveThis cross‐sectional study examined racial/ethnic differences in meeting the 2008 United States Department of Health and Human Services Physical Activity Guidelines aerobic component (≥150 moderate‐to‐vigorous minutes/week in bouts of ≥10 minutes) among persons with or at risk of radiographic knee osteoarthritis (RKOA).MethodsWe evaluated African American versus white differences in guideline attainment using multiple logistic regression, adjusting for sociodemographic (age, sex, site, income, and education) and health factors (comorbidity, depressive symptoms, overweight/obesity, and knee pain). Our analyses included adults ages 49–84 years who participated in accelerometer monitoring at the Osteoarthritis Initiative 48‐month visit (n = 1,142 with RKOA and n = 747 at risk of RKOA).ResultsTwo percent of African Americans and 13.0% of whites met the guidelines. For adults with and at risk of RKOA, significantly lower rates of guidelines attainment among African Americans compared to whites were partially attenuated by health factor differences, particularly overweight/obesity and knee pain (with RKOA: adjusted odds ratio [OR] 0.24, 95% confidence interval [95% CI] 0.08–0.72; at risk of RKOA: OR 0.28, 95% CI 0.07–1.05).ConclusionDespite known benefits from physical activity, attainment of the physical activity guidelines among persons with and at risk of RKOA was low. African Americans were 72–76% less likely than whites to meet the guidelines. Culturally relevant interventions and environmental strategies in the African American community targeting overweight/obesity and knee pain may reduce future racial/ethnic differences in physical activity and improve health outcomes.
Assessment of SpondyloArthritis International Society criteria for axial spondyloarthritis in chronic back pain patients with a high prevalence of HLA–B27
Authors: Bakland Gunnstein , Alsing Rikke , Singh Kulbir , Nossent Johannes C. 
Published: November 2012

AbstractObjectiveThe Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (SpA) allow SpA classification of HLA–B27–positive patients if ≥2 specific clinical SpA features are present. We investigated the performance of these clinical ASAS criteria in a population with a high prevalence of HLA–B27.MethodsA total of 807 persons reporting chronic back pain (CBP) lasting for >4 weeks during a population survey underwent a clinical, laboratory, and radiologic evaluation. The ASAS criteria for axial SpA were then used to determine classification status.ResultsOnly 332 patients (41% of all CBP patients) fulfilled the prerequisite ASAS definitions for CBP (duration of ≥3 months and onset at age <45 years). In this ASAS‐defined CBP cohort (51% women, CBP onset at age 27.2 years, 17% HLA–B27 positive), ASAS classification criteria for axial SpA were met by 8.4% of patients. Radiographic SpA by the modified New York criteria was present in 2.4%, while 6% fulfilled the clinical arm of the ASAS SpA criteria only. One‐fifth of patients with clinical SpA developed radiographic evidence of SpA after a median of 8 years.ConclusionApplication of the clinical ASAS classification criteria in an area with a high prevalence of HLA–B27 leads to significant increases in the prevalence of axial SpA compared to radiologic SpA among CBP patients. This increase in the prevalence of disease is likely to have significant ramifications for patient management and health care systems.
Excess body weight and four‐year function outcomes: Comparison of African Americans and whites in a prospective study of osteoarthritis
Authors: Colbert Carmelita J. , Almagor Orit , Chmiel Joan S. , Song Jing , Dunlop Dorothy , Hayes Karen W. , Sharma Leena 
Published: November 2012

AbstractObjectiveWe evaluated whether African Americans in the Osteoarthritis Initiative (OAI) have a greater risk (versus whites) of poor 4‐year function outcome within strata defined by sex, body mass index (BMI), and waist circumference.MethodsUsing Western Ontario and McMaster Universities Osteoarthritis Index function, 20‐meter walk, and chair stand performance, poor outcome was defined as moving into a worse function group or remaining in the 2 worst groups over 4 years. Logistic regression was used to evaluate the relationship between racial group and outcome within each stratum, adjusting for age, education, and income, and then further adjusting for BMI, comorbidity, depressive symptoms, physical activity, knee pain, and osteoarthritis (OA) severity.ResultsIn 3,695 persons with or at higher risk for knee OA, higher BMI and large waist circumference were each associated with poor outcome. Among women with high BMI and among women with large waist circumference, African Americans were at greater risk for poor outcome by every measure, adjusting for age, education, and income. From fully adjusted models, potential explanatory factors included income, comorbidity, depressive symptoms, pain, and disease severity. Findings were less consistent for men, emerging only for the 20‐meter walk or chair stand outcomes, and potentially explained by age and knee pain.ConclusionAmong OAI women with excess body weight, African Americans are at greater risk than whites for poor 4‐year outcome. Modifiable factors that may help to explain these findings in the OAI include comorbidity, depressive symptoms, and knee pain. Targeting such factors, while supporting weight loss, may help to lessen the outcome disparity between African American and white women.
Elderly‐ versus younger‐onset rheumatoid arthritis: Higher levels of ultrasound‐detected inflammation despite comparable clinical disease activity
Authors: Dejaco Christian , Duftner Christina , Wipfler‐Freissmuth Edith , Weiss Helmut , Schneider Thomas , Schirmer Michael 
Published: November 2012

AbstractObjectiveTo compare ultrasound‐verified joint inflammation between elderly‐onset rheumatoid arthritis (EORA) and younger‐onset rheumatoid arthritis (YORA) patients.MethodsWe conducted a retrospective analysis of 145 consecutive rheumatoid arthritis patients routinely assessed by sonography of wrists, metacarpophalangeal joints, and proximal interphalangeal joints, including semiquantitative scoring of synovial hypertrophy/effusion (SH/E) and power Doppler (PD) signals. Global ultrasound (GU) scores were calculated adding SH/E and PD results. EORA was defined by disease onset at age ≥60 years. Number of tender joints and swollen joints, global assessment of disease activity by physician or patient, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), and Simplified Disease Activity Index (SDAI) scores were recorded. Respective values for disease activity were accounted for in group comparisons using SPSS statistical software (version 18.0).ResultsSeventy patients were diagnosed with EORA (mean ± SD age 71.0 ± 7.3 years, 81.4% women) and 75 patients with YORA (mean ± SD age 46.8 ± 10.2 years, 86.7% women). EORA patients had higher GU scores (median 18.5 [interquartile range (IQR) 17.0] versus 12.0 [IQR 15.0], P = 0.009) and SH/E scores (median 12.0 [IQR 10.0] versus median 9.0 [IQR 9.0], P = 0.004) than patients with YORA. Patients with EORA were more likely to show PD signals in at least 1 joint than YORA patients (85% versus 72%; odds ratio 3.9 [95% confidence interval 1.3–11.5], P = 0.015). DAS28, CDAI, and SDAI scores did not differ between the groups. The sonographic pattern of joint involvement was similar in both groups, with active inflammation most commonly presenting at the wrists.ConclusionUltrasound examination indicated higher inflammatory burden in EORA patients than in YORA patients despite similar clinical disease activity.
Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: A prospective study
Authors: Chen Jiunn‐Horng , Pan Wen‐Harn , Hsu Chih‐Cheng , Yeh Wen‐Ting , Chuang Shao‐Yuan , Chen Pin‐Yu , Chen Hui‐Chen , Chang Chwen‐Tzuei , Huang Wei‐Lun 
Published: November 2012

AbstractObjectiveHyperuricemia is the most important risk factor for the development of gout; however, not all patients with hyperuricemia develop gout, and patients experiencing a gout attack are not necessarily found to have hyperuricemia. We hypothesized that the interactions between serum uric acid (sUA) and other potential metabolic comorbidities increase the risk of gout development.MethodsA prospective study was conducted to link baseline metabolic profiles from the MJ Health Screening Center to gout outcomes extracted from the Taiwan National Health Insurance database. A Cox proportional hazards model was used to assess the metabolic risks for incident gout stratified by hyperuricemia status (sUA level >7 mg/dl or not).ResultsDuring a mean followup period of 6.45 years (261,500 person‐years), 1,189 patients with clinical gout (899 men, 202 women ages >50 years, and 88 women ages ≤50 years) were identified among the 40,513 examinees. The multivariate adjusted hazard ratios (HRs) of hyperuricemia for gouty arthritis were 5.80 (95% confidence interval [95% CI] 4.93–6.81) in men and 4.37 (95% CI 3.38–5.66) in women. Hypertriglyceridemia (triglyceride level >150 mg/dl) was found as an independent risk factor, with HRs of 1.38 (95% CI 1.18–1.60) in men with hyperuricemia and 1.40 (95% CI 1.02–1.92) in men without hyperuricemia. General obesity (body mass index >27 kg/m2) was independently associated with gout in older women, with HRs of 1.72 (95% CI 1.15–2.56) in women with hyperuricemia and 2.19 (95% CI 1.47–3.26) in women without hyperuricemia.ConclusionGeneral obesity in women and hypertriglyceridemia in men may potentiate an sUA effect for gout development. Further investigation is needed.
Self‐oscillation loop design and measurement for an MEMS resonant accelerometer
Authors: Heng Liu , Li Meng Rui 
Published: November 2012

SUMMARYThis paper provides detailed information about the dynamic model and closed‐loop control theory of resonant accelerometer based on electrostatic stiffness. After the resonant accelerometer principle based on electrostatic stiffness has been analyzed, a dynamic model was built. According to the requirement of constant stable vibration amplitude for a different applied acceleration, control equations based on self‐sustained oscillation loop technology were also developed for the whole system. By applying the averaging method, the system behaviors were analyzed, and equilibria for the vibration amplitude were achieved. Theoretical analysis and simulation showed that the vibration amplitude became stable and attractive only when the stable criterion was satisfied. Using a PI controller, constant level vibrating amplitude can be achieved when the input acceleration changes. A resonant accelerometer was fabricated using bulk‐silicon dissolved process. Under the aforementioned conditions, the accelerometer was driven and tested using a self‐sustained oscillation loop. When the sensing voltage was 5 V, the sensitivity was 58 Hz/g, and the resolution was 3.5 mg for a single vibrating beam. Copyright © 2012 John Wiley & Sons, Ltd.