bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute lymphocyte count recovery at 1 month after transplantation predicts favorable outcomes of patients with hepatocellular carcinoma
Authors: Zheng Zhiyun , Lin Bingyi , Zhang Jing , Yang Zhe , Xie Haiyang , Zhou Lin , Zhang Min , Zheng Shusen 
Published: September 2014

AbstractBackground and AimsAbsolute lymphocyte count (ALC) and the recovery of ALC after treatment have been identified as a prognostic biomarker for several malignancies. In this study, we aimed to investigate the prognostic role of peritransplant ALC and ALC recovery after liver transplantation (LT) in hepatocellular carcinoma (HCC) patients.MethodsA total of 269 HCC patients undergoing LT were enrolled in our study. Clinicopathological data were retrospectively collected and reviewed. Peritransplant ALC and the change of ALC (2 weeks, 1 month, 3 months post‐LT) were carefully monitored. All potential risk factors were analyzed by univariate and multivariate cox regression analysis.ResultsOver a mean follow‐up of 35.9 months, 120 recurrences and 89 deaths were recorded. In the multivariate analysis, HCC with ALC no recovery at 1 month after LT (P < 0.001), high pretransplant alpha fetoprotein (P = 0.010), total tumor size > 8 cm (P = 0.003), and beyond Milan criteria (P < 0.001) were four independent risk factors for HCC recurrence. For overall survival (OS) after LT, ALC no recovery at 1 month after LT (P = 0.003), total tumor size > 8 cm (P = 0.011), pretransplant albumin < 2.8 g/dL (P = 0.049), model of end‐stage liver disease score > 15 (P = 0.017), and beyond Milan criteria (P = 0.001) were significantly related to poor OS. When subgroup analyses were performed according to the Milan criteria, the results showed that the recovery of ALC at 1 month after LT still indicated longer recurrence‐free survival (RFS) (P < 0.001) and OS (P = 0.005) beyond Milan criteria as well as RFS (P < 0.001) within Milan criteria, but not OS (P = 0.157) within Milan criteria.ConclusionsALC recovery at 1 month after LT indicated favorable outcomes of HCC patients.
Ubiquitin D is an independent prognostic marker for survival in stage IIB–IIC colon cancer patients treated with 5‐fluoruracil‐based adjuvant chemotherapy
Authors: Zhao Senlin , Jiang Tao , Tang Huamei , Cui Feifei , Liu Chenchen , Guo Feng , Lu Huijun , Xue Yingming , Jiang Weiliang , Peng Zhihai , Yan Dongwang 
Published: September 2014

AbstractBackgroundPostoperative 5‐fluoruracil (5‐FU)‐based adjuvant chemotherapy is recommended for stage II colon cancer patients with high conventional risk factors; however, some of these patients still experience tumor recurrence. Identifying novel biomarkers to distinguish the risk of tumor recurrence after surgery is vital for improving their prognoses. We previously showed that ubiquitin D (UBD) can predict the prognosis of colon cancer; however, there are limited data on whether UBD is an independent prognostic factor for stage II patients treated with 5‐FU‐based adjuvant chemotherapy.MethodsQuantitative real‐time PCR and Western blot analyses were used to examine UBD expression in randomly selected stage II patients' tumor tissues. UBD expression and p65 distribution were assessed using immunohistochemistry in paraffin‐embedded specimens from the 101 tumor recurrence patients and 178 nonrelapse patients who received postoperative 5‐FU‐based adjuvant chemotherapy.ResultsUBD expression, both at transcriptional and posttranscriptional levels, was higher in relapse tumors (P < 0.001). Immunohistochemistry staining of UBD and p65 showed significant differences between the two groups (P < 0.001). Patients with tumor tissues that UBD‐positive expression alone or in combination with p65 nuclei translocation recurred early had a significantly shorter survival time (P < 0.001), especially in stage IIB‐IIC patients. UBD‐positive expression accompanied with p65 nuclei translocation was a significant independent predictive high risk factor for overall survival (HR 8.76; 95% CI, 5.35–14.27; P = 0.004) and disease‐free survival (HR 5.70; 95% CI, 1.43–11.55; P = 0.016).ConclusionUBD may help to identify recurrent risk in stage IIB‐IIC colon cancer patients and further predict which patients benefit from postoperative 5‐FU‐based adjuvant chemotherapy.
Cystic fibrosis: An update for clinicians. Part 2: Hepatobiliary and pancreatic manifestations
Authors: Ledder Oren , Haller Wolfram , Couper Richard TL , Lewindon Peter , Oliver Mark 
Published: September 2014

AbstractThis paper, the second in the series, will build on the first and explore the importance of liver and pancreatic manifestations of cystic fibrosis (CF) and the effect on morbidity and mortality of this multifaceted genetic condition. It will also further develop the critical role of the gastroenterologist as part of the multidisciplinary group of clinicians and allied health staff in the effective management of patients withCF.
The modest alcohol consumption reduces the incidence of fatty liver in men: a population‐based large‐scale cohort study
Authors: Hashimoto Yoshitaka , Hamaguchi Masahide , Kojima Takao , Ohshima Yasuhiro , Ohbora Akihiro , Kato Takahiro , Nakamura Naoto , Fukui Michiaki 
Published: September 2014

AbstractBackground and AimRecent cross‐sectional studies have been reported the possibility that light to moderate alcohol consumption might be negatively associated with fatty liver. However, there has been no large‐scale longitudinal study addressing an impact of alcohol consumption on a development of fatty liver diagnosed by ultrasonography. Thus, we investigated the impact of alcohol consumption on a natural history of fatty liver.MethodsWe analyzed 5437 apparently healthy Japanese who received the health checkup programs repeatedly over 10 years. In this study, we used a standardized questionnaire for addressing the medical history and lifestyle and used a standardized ultrasonographic diagnosis for fatty liver. The total amount of alcohol consumed per week was calculated and classified into four grades; none or minimal, light, moderate, or heavy alcohol consumption (< 40, 40–140, 140–280 or > 280 g/week, respectively). The hazard risks of alcohol consumption for the development of fatty liver were calculated by Cox hazard model after adjusting age, BMI, and parameters for lifestyle.ResultsDuring 10 years of follow‐up, fatty liver was continuously diagnosed just in 10% of men and 20% of women with fatty liver at the baseline. In men, the adjusted hazard risks of light and moderate alcohol consumption for the development of fatty liver were 0.72 (95% confidence interval 0.60–0.86, P < 0.001) and 0.69 (0.57–0.84, P < 0.001), respectively. However, they were not significant in women.ConclusionsThe newly onset of fatty liver was significantly repressed in apparently healthy men who consume light to moderate alcohol.
Evaluation of two observational pain assessment scales during the anaesthesia recovery period in Chinese surgical older adults
Authors: Guo Li‐Li , Li Li , Liu Yao‐Wei , Herr Keela 
Published: September 2014

Aims and objectivesTo evaluate the reliability and validity of the Pain Assessment in Advanced Dementia scale and the Checklist of Nonverbal Pain Indicators in Chinese older adults post surgery during the anaesthesia recovery period.BackgroundPain assessment in older surgical patients is complicated by factors such as anaesthesia and opioid administration. Although observational pain behavioural assessment tools have been validated for those unable to self‐report, research on their application during the anaesthesia recovery period is limited.DesignA prospective correlational design.MethodsNinety‐three older patients admitted for scheduled abdominal surgery were recruited in a university‐affiliated hospital. The two observational scales were used to conduct pain assessments during the anaesthesia recovery period. On the first and the third postoperative day, participants recalled their pain intensity during the recovery period using the Numeric Rating Scale or the Faces Pain Scale‐Revised.ResultsThe internal consistency reliability of the Pain Assessment in Advanced Dementia scale and the Checklist of Nonverbal Pain Indicators was 0·81 and 0·69 respectively. The correlation between scores of the two observational scales was 0·95. The recalled self‐reports of pain intensity were significantly correlated. The correlation of the Pain Assessment in Advanced Dementia scale and patients’ recalled self‐reports was 0·55, 0·54, and the correlation between the Checklist of Nonverbal Pain Indicators and the two recalled pain scores was both 0·60.ConclusionsBoth the two observational scales had good reliability and validity when used to assess pain in Chinese surgical older adults during the anaesthesia recovery period.Relevance to clinical practiceObservational pain scales can be useful as a tool for patients unable to self‐report. Accurate use of one of the observational pain tools can help identify pain during the anaesthesia recovery period, when patients are unable to self‐report, to support effective pain management during this period.
Supporting family carers providing end‐of‐life home care: a qualitative study on the impact of a hospice at home service
Authors: Jack Barbara A , O'Brien Mary R , Scrutton Joyce , Baldry Catherine R , Groves Karen E 
Published: September 2014

Aims and objectivesTo explore bereaved family carers' perceptions and experiences of a hospice at home service.BackgroundThe increasing demand for the development of home‐based end‐of‐life services is not confined to the western world; such services are also emerging in resource‐poor countries where palliative care services are developing with limited inpatient facilities. Despite this growing trend, studies show a variety of interrelated factors, with an emphasis on the availability of informal carers and their ability to cope, which can influence whether terminally ill patients actually remain at home. A hospice at home service was developed to meet patients' and families' needs by providing individually tailored resources.DesignA qualitative study.MethodsData were collected by semi‐structured, digitally recorded interviews from 20 family carers who had experienced the service. Interviews were transcribed verbatim and a thematic approach adopted for analysis.ResultsAll participants reported a personal positive impact of the service. Family carers commented the service provided a valued presence, they felt in good hands and importantly it helped in supporting normal life.ConclusionsThe impact of an individualised, targeted, hospice at home service using dedicated, palliative care trained, staff, is perceived positively by family carers and importantly, supportive of those with additional caring or employment commitments.Relevance to clinical practiceThe emergence of hospice at home services has resulted in more options for patients and their families, when the increased amount of care a family member has to provide in these circumstances needs to be adequately supported, with the provision of a flexible service tailored to individual needs and delivered by appropriately trained staff.
Isolation of turbinaric acid as a chemomarker of Turbinaria conoides (J. Agardh) Kützing from South Pacific Islands
Authors: Le Lann Klervi , Kraffe Edouard , Kervarec Nelly , Cerantola Stéphane , Payri Claude Elisabeth , Stiger‐Pouvreau Valérie 
Published: September 2014

Several species of the genus Turbinaria coexist along the coasts of islands in the Indian and Pacific Oceans. Among these brown algae, Turbinaria ornata and T. conoides are sister species that are difficult to differentiate using exclusively morphological characters. Based on in vivo nuclear magnetic resonance and chromatographic techniques, i.e., liquid and gas chromatography‐mass spectrometry analysis, combined with phylogenetic data, we successfully identified turbinaric acid in T. conoides samples from several Indian and Pacific Ocean islands. This nonvariable discriminant molecule was only identified in T. conoides specimens, but not in the two allied species T. ornata and T. decurrens. Results are discussed with regard to turbinaric acid as an interesting chemomarker isolated from T. conoides and the rapid discrimination of Turbinaria specimens using chemical assays.
Predictors of Task-Persistent and Fear-Avoiding Behaviors in Women with Sexual Pain Disorders
Authors: Brauer Marieke , Lakeman Mariëlle , van Lunsen Rik , Laan Ellen 
Published: September 2014

Abstract

Introduction
Dyspareunia and vaginismus are the most common sexual pain disorders (SPDs). Literature suggests that many women with dyspareunia continue with intercourse despite pain (task persistence), whereas many women with vaginismus avoid penetrative activities that may cause pain (fear avoidance). Both forms of sexual pain behavior may maintain or aggravate complaints.

Aim
This study examined (i) whether women with SPD differ from pain-free controls in motives for sexual intercourse, sexual autonomy, maladaptive beliefs regarding vaginal penetration, and partner responses to pain; and (ii) which of these factors best predict whether women with SPD stop or continue painful intercourse (attempts).

Methods
Women with superficial dyspareunia (n = 50), women with lifelong vaginismus (n = 20), and pain-free controls (n = 45) completed questionnaires.

Main Outcome Measures
For Aim 1, the main outcome measures were (i) motives for intercourse; (ii) sexual autonomy; (iii) maladaptive beliefs regarding vaginal penetration; and (iv) partner responses to pain. For Aim 2, sexual pain behavior (to continue or discontinue with painful intercourse) was the outcome measure.

Results
(i) Women with dyspareunia exhibited more mate guarding and duty/pressure motives for intercourse and were less sexually autonomous than controls. (ii) Symptomatic women had more maladaptive penetration-related beliefs than controls, with women with vaginismus reporting the strongest maladaptive beliefs. (iii) Partners of women with dyspareunia self-reported more negative responses to pain than those of women with vaginismus. (iv) The factors that best predicted sexual pain behavior were the partner responses to pain and the woman's maladaptive beliefs regarding vaginal penetration.

Conclusions
Our findings reveal support for task persistence in women with dyspareunia and fear avoidance in women with lifelong vaginismus. As such, it is important to consider these distinct types of responding to sexual pain when treating SPD.
Anti‐kelch‐like 12 and anti‐hexokinase 1: novel autoantibodies in primary biliary cirrhosis
Authors: Norman Gary L. , Yang Chen‐Yen , Ostendorff Heather P. , Shums Zakera , Lim Mark J. , Wang Jinjun , Awad Amany , Hirschfield Gideon M. , Milkiewicz Piotr , Bloch Donald B. , Rothschild Kenneth J. , Bowlus Christopher L. , Adamopoulos Iannis E. , Leung Patrick S.C. , Janssen Harry J. , Cheung Angela C. , Coltescu Catalina , Gershwin M. Eric 
Published: September 2014

AbstractBackground & AimsUsing high‐density human recombinant protein microarrays, we identified two potential biomarkers, kelch‐like 12 (KLHL12) and hexokinase‐1 (HK1), in primary biliary cirrhosis (PBC). The objective of this study was to determine the diagnostic value of anti‐KLHL12/HK1 autoantibodies in PBC. Initial discovery used sera from 22 patients with PBC and 62 non‐PBC controls. KLHL12 and HK1 proteins were then analysed for immunoglobulin reactivity by immunoblot and enzyme‐linked immunosorbent assay (ELISA) in two independent cohorts of PBC and disease/healthy control patients.MethodsSerum samples from 100 patients with PBC and 165 non‐PBC disease controls were analysed by immunoblot and samples from 366 patients with PBC, 174 disease controls, and 80 healthy donors were tested by ELISA.ResultsAnti‐KLHL12 and anti‐HK1 antibodies were each detected more frequently in PBC compared with non‐PBC disease controls (P < 0.001). Not only are both markers highly specific for PBC (≥95%) but they also yielded higher sensitivity than anti‐gp210 and anti‐sp100 antibodies. Combining anti‐HK1 and anti‐KLHL12 with available markers (MIT3, gp210 and sp100), increased the diagnostic sensitivity for PBC. Most importantly, anti‐KLHL12 and anti‐HK1 antibodies were present in 10–35% of anti‐mitochondrial antibody (AMA)‐negative PBC patients and adding these two biomarkers to conventional PBC assays dramatically improved the serological sensitivity in AMA‐negative PBC from 55% to 75% in immunoblot and 48.3% to 68.5% in ELISA.ConclusionsThe addition of tests for highly specific anti‐KLHL12 and anti‐HK1 antibodies to AMA and ANA serological assays significantly improves efficacy in the clinical detection and diagnosis of PBC, especially for AMA‐negative subjects.
The relationship between upper airways and craniofacial morphology studied in 3D. A CBCT study
Authors: Di Carlo G. , Polimeni A. , Melsen B. , Cattaneo P. M. 
Published: September 2014

Structured AbstractObjectivesTo assess whether morphology and dimension of the upper airway differ between patients characterized by various craniofacial morphology.Setting and Sample PopulationNinety young adult patients from the Postgraduate Clinic, Section of Orthodontics, Department of Dentistry, Health, Aarhus University, Denmark, with no obvious signs of respiratory diseases and no previous adeno‐tonsillectomy procedures. Thirty patients were characterized as Class I (−0.5 < ANB < 4.5), 30 as Class II (ANB > 4.5), and 30 as Class III (ANB < −0.5).Material and MethodsCone‐beam computed tomography (CBCT) scans obtained in a supine position for all patients. Cephalometric landmarks were identified in 3D. Sagittal and transversal dimensions, cross sections, and partial and total volumes of the upper airway were correlated with the cephalometric measurements in all three planes of space. The cross‐sectional minimal area of the upper airway was assessed as well.ResultsNo statistical significant relationships between dimension and morphology of upper airways and skeletal malocclusion were found.ConclusionDifferences in craniofacial morphology as identified by the sagittal jaw relationship were not correlated with variation in upper airway volumes. A clinical significant relation was detected between minimal area and total upper airway volume.
The role of the dental practitioner in diagnosing connective tissue and other systemic disorders: a case report of a patient diagnosed with type III Ehlers–Danlos syndrome
Authors: Awal D. , Lloyd T.W. , Petersen H.J. 
Published: September 2014

AbstractAn adolescent patient was referred to our specialist oral surgery unit for orthodontic exposure of an ectopic upper canine. The medical history revealed a recent diagnosis of mitral valve prolapse as well as an anecdotal tendency towards regular fainting/lethargy. Examination revealed a hypermobile temporomandibular joint, and an orthopantomogram showed lower supernumerary premolar teeth. Combined, these findings indicated a likely underlying connective tissue disorder, and an indirect referral to a specialist in hypermobility syndromes confirmed a diagnosis of type III Ehlers–Danlos syndrome with postural orthostatic tachycardia syndrome. This case highlights the importance of the dental practitioner in being able to provide holistic care for their patients.
Generalized Lenticular Atrophoderma of Pasini and Pierini
Authors: Avancini Joao , Valente Neusa Yuriko S. , Romiti Ricardo 
Published: September 2014

AbstractWe present a 16‐year‐old boy with multiple, well‐circumscribed, atrophic, light‐brown patches on his neck, chest, and back. The authors believe that it represents an unusual presentation of atrophoderma of Pasini and Pierini and suggest the designation “generalized lenticular APP.”
Pathotypic and genetic diversity in the population of Rhizoctonia solani AG1‐IA causing rice sheath blight in China
Authors: Wang L. , Liu L. M. , Hou Y. X. , Li L. , Huang S. W. 
Published: September 2014

Sheath blight, caused by Rhizoctonia solani AG1‐IA, is one of the most serious diseases of rice. In this study, a total of 175 isolates of R. solani AG1‐IA were collected from five rice‐growing regions in China. Pathogenicity tests revealed that all isolates were virulent to five cultivars with different levels of resistance at the rice seedling stage in the greenhouse. There was considerable variation in aggressiveness, and the isolates were classified into three pathotypes based on disease severity, with moderately virulent isolates prevalent in the population. Forty‐three haplotypes were identified based on ITS sequencing, and 39 haplotypes were distinct among isolates. There were high levels of haplotype diversity and nucleotide diversity within the populations of R. solani AG1‐IA. High gene flow (Nm = 1·63–5·22) was detected, consistent with relatively low differentiation between pairs of populations. Five populations were divided into two distinct clusters by the unweighted pair group method with arithmetic mean (UPGMA), and no spatial population differentiation was discernible. The majority (97·8%) of genetic diversity was distributed among isolates within populations, with only 2·2% of the genetic diversity attributed to differences among populations. The star‐like shape of the haplotype network provided evidence of signatures of population expansion in recent history. No significant relationships were found between the genetic diversity and aggressiveness or geographic origin among populations of R. solani AG1‐IA. These results highlight that the population characteristics of R. solani AG1‐IA should be taken into account in evaluating the germplasm resistance of rice cultivars to sheath blight.
Deciding treatment for miscarriage – experiences of women and healthcare professionals
Authors: Linnet Olesen Mette , Graungaard Anette H. , Husted Gitte R. 
Published: September 2014

IntroductionWomen experiencing miscarriage are offered a choice of different treatments to terminate their wanted pregnancy at a time when they are often shocked and distressed. Women's and healthcare professionals’ experiences of the decision‐making process are not well described. We aimed to gain insight into this process and the circumstances that may affect it.MethodA qualitative study using a grounded theory approach. Data were obtained through semi‐structured interviews with six women who had chosen and completed either surgical, medical or expectant treatment for miscarriage and five healthcare professionals involved in the decision‐making at an emergency gynaecological department in Denmark. An inductive explorative method was chosen due to limited knowledge about the decision‐making process, and a theoretical perspective was not applied until the final analysis.ResultsDespite information and pretreatment counselling, choice of treatment was often determined by unspoken emotional considerations, including fear of seeing the foetus or fear of anaesthesia. These considerations were not discussed during the decision‐making process, which was a time when the women were under time pressure and experienced emotional distress. Healthcare professionals did not explore women's considerations for choosing a particular treatment and prioritised information differently. We found theory about coping and decision‐making in stressful situations useful in increasing our understanding of the women's reactions. In relation to theory about informed consent, our findings suggest that women need more understanding of the treatments before making a decision. This study is limited due to a small sample size, but it generates important findings that need to be examined in a larger sample.ConclusionFrequently, women did not use information provided about treatment pros and cons in their decision‐making process. Because of unspoken thoughts, and women's needs being unexplored by healthcare professionals, information did not target women's needs and their reasoning remained unapparent.