bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Personal Imperative of Revelation: Emil Brunner, Dogmatics and Theological Existence
Authors: Brown Cynthia Bennett 
Published: October 2012

AbstractBased on the theology of Emil Brunner, this article seeks to demonstrate the relevance, even the imperative nature, of personal encounter both for the work of dogmatics and for theological existence. In particular it assesses what impact the personalness of God's self-revelation should have, not just on one's doctrinal conclusions, but also on one's self as a theologian. A range of Brunner's writings forms the backdrop for this focused study of a paradigm which shapes his theology and methodology: personal encounter. I start by introducing the broader context of Brunner's presuppositions about the theological task, including his regard for divine self-communication. With this in mind, attention will be paid to the relationship between revelation and scripture, and in particular to the Christocentric, personal and enduring character of God's unveiling. Brunner's regard for the apostolic witness as the authoritative testimony to God's full disclosure in Christ is high and determines the position that he affords the Bible throughout his work. A summary of Brunner's treatment of the divine-human encounter will follow, with a view to understanding him on this subject in his own terms. His small publication by the same name, The Divine-Human Encounter, serves as the focus of this examination. The term ‘personal correspondence’ requires special consideration for the central position it enjoys in Brunner's conception of divine revelation and its relationship to dogmatics. Further expressions related to this theme will come to light in the process of answering two questions regarding the connection between personal encounter in scripture and the work of theology. First, how true is our doctrine when its expression becomes distanced from the language of divine-human encounter which characterises revelation? Second, what is the relationship between scripture as theology's primary source and the ongoing revelation of God to the believer in personal encounter? The suggestion that theology cannot be restricted to intellectual pursuit will not be universally applauded, but the proposal that God's self-unveiling obliges a change in existence and not just an adjustment in knowledge is one that Brunner deems unavoidable. In this light I conclude by suggesting that the personal encounter of revelation issues an imperative for both individual and communal existence which must be considered by all who undertake the theological task.
Diet–obesity associations in children: approaches to counteract attenuation caused by misreporting
Authors: Börnhorst Claudia , Huybrechts Inge , Hebestreit Antje , Vanaelst Barbara , Molnár Dénes , Bel-Serrat Silvia , Mouratidou Theodora , Moreno Luis A , Pala Valeria , Eha Marge , Kourides Yiannis A , Siani Alfonso , Eiben Gabriele , Pigeot Iris 
Published: October 2012

AbstractObjectiveMeasurement errors in dietary data lead to attenuated estimates of associations between dietary exposures and health outcomes. The present study aimed to compare and evaluate different approaches of handling implausible reports by exemplary analysis of the association between dietary intakes (total energy, soft drinks, fruits/vegetables) and overweight/obesity in children.DesignCross-sectional multicentre study.SettingKindergartens/schools from eight European countries participating in the IDEFICS Study.SubjectsChildren (n5357) aged 2–9 years who provided one 24 h dietary recall and complete covariate information.ResultsThe 24 h recalls were classified into three reporting groups according to adapted Goldberg cut-offs: under-report, plausible report or over-report. In the basic logistic multilevel model (adjusted for age and sex, including study centre as random effect), the dietary exposures showed no significant association with overweight/obesity (energy intake: OR=0·996 (95 % CI 0·983, 1·010); soft drinks: OR = 0·999 (95 % CI 0·986, 1·013)) and revealed even a positive association for fruits/vegetables (OR = 1·009 (95 % CI 1·001, 1·018)). When adding the reporting group (dummy variables) and a propensity score for misreporting as adjustment terms, associations became significant for energy intake as well as soft drinks (energy: OR = 1·074 (95 % CI 1·053, 1·096); soft drinks: OR = 1·015 (95 % CI 1·000, 1·031)) and the association between fruits/vegetables and overweight/obesity pointed to the reverse direction compared with the basic model (OR = 0·993 (95 % CI 0·984, 1·002)).ConclusionsAssociations between dietary exposures and health outcomes are strongly affected or even masked by measurement errors. In the present analysis consideration of the reporting group and inclusion of a propensity score for misreporting turned out to be useful tools to counteract attenuation of effect estimates.
The Market for U.S. Livestock Feed Proteins
Authors: Mathews Kenneth H. , McConnell Michael J. 
Published: October 2012

AbstractParameters that characterize markets for livestock feed ingredients and inform an increasing array of policies motivated by a range of environmental, market, and animal disease issues are largely absent from the literature, which necessitates the use of often misleading assumptions in analyses of proposed feed‐market policies. Such parameters are derived here from a theoretically consistent, dual translog cost model of U.S. protein and energy feed markets. Own‐price elasticities ranged from a relatively inelastic −0.139 for feedgrains to a relatively elastic −0.568 for meat and bone meal (MBM). The cross elasticity for ethanol co‐products and oilseed meals (0.168) is larger than the elasticity with co‐products and feedgrains (0.024). Higher prices for protein feeds likely result in some substitution of feed grains for some protein (e.g. corn by oilseed meals = 0.125), which may also partially account for the relatively small feedgrains cross elasticity. Policies implemented as a result of bovine splongiform encephalopathy adversely affected the share of total costs attributed to MBM, but had a positive effect on oilseed meal cost share.
Predicting pseudoknotted structures across two RNA sequences
Authors: Sperschneider Jana , Datta Amitava , Wise Michael J. 
Published: October 2012

Abstract
Motivation: Laboratory RNA structure determination is demanding and costly and thus, computational structure prediction is an important task. Single sequence methods for RNA secondary structure prediction are limited by the accuracy of the underlying folding model, if a structure is supported by a family of evolutionarily related sequences, one can be more confident that the prediction is accurate. RNA pseudoknots are functional elements, which have highly conserved structures. However, few comparative structure prediction methods can handle pseudoknots due to the computational complexity.
Results: A comparative pseudoknot prediction method called DotKnot-PW is introduced based on structural comparison of secondary structure elements and H-type pseudoknot candidates. DotKnot-PW outperforms other methods from the literature on a hand-curated test set of RNA structures with experimental support.
Availability: DotKnot-PW and the RNA structure test set are available at the web site http://dotknot.csse.uwa.edu.au/pw.
Contact: janaspe@csse.uwa.edu.au
Supplementary information: Supplementary data are available at Bioinformatics online.
Nuclear transferred embryonic stem cells for analysis of B1 B-lymphocyte development
Authors: Takase Mitsuyo , Iida Ryuji , Maruya Mikako , Sakaue-Sawano Asako , Miyawaki Atsushi , Wakayama Teruhiko , Nishigami Satoshi , Fagarasan Sidonia , Kanagawa Osami 
Published: October 2012

Abstract
The transfer of nuclei of fully differentiated cells into enucleated oocytes is a well-recognized method for the generation of embryonic stem (ES) cells. Here, we demonstrate that nuclear transferred ES (NT-ES) cells can be established with high efficiency using innate-like B lymphocytes as donor cells. We established two mouse lines carrying rearranged immunoglobulin heavy and light chains using NT-ES cells containing nuclei from peritoneal cavity B1 cells. Analysis of B1 clone lines revealed that the B1-cell generation critically depends on the interaction between antigen (possibly self-antigen) and surface immunoglobulin, while the B1-cell maintenance requires the peritoneal environment. The B1-cell expansion takes place in spleen, and is held in check by competitor B2 cells. The results indicate that the NT-ES method could replace the transgenic or knock-in mouse approaches currently used to study the biology of cells that undergo somatic rearrangements of their antigen receptor genes.
An extended service recovery model: the moderating impact of temporal sequence of events
Authors: Prasongsukarn Kriengsin , Patterson Paul G. 
Published: October 2012

PurposeThe purpose of this empirical paper is to explore for the first time, in a temporal sequence of events framework, how the various forms of justice (procedural, interactional and outcome) impact on customer satisfaction with service recovery.Design/methodology/approachEmploying scenarios, an experimental design was employed with data collected from a student sample in an Eastern collectivist culture (Thailand).FindingsThe results reveal that affirmation of perceptions of all three forms of justice positively impact overall service recovery satisfaction. However, unlike previous models of recovery satisfaction, the findings presented here suggest a temporal sequence of events model involving the causal ordering of the three justice dimensions such that distributive justice mediates the relationship between procedural and interactional justice, and ultimate recovery satisfaction.Research limitations/implicationsBased on the findings here, future studies using the three forms of justice should consider the temporal element and undertake longitudinal analysis.Practical implicationsThe findings suggest that organizations should pay special attention to delivering high levels of interactional and procedural justice as they precede, and have an impact on, subsequent perceptions of outcome justice (i.e. compensation, re‐done work, etc.) in a service recovery situation.Originality/valueThis study adds to the knowledge on how firms can best recover from a service failure situation.
“Shared Pathway” national pilot project: the experience of a secure learning disability service
Authors: Esan Fola , Pittaway Melanie , Nyamande Beatrice , Graham Alex 
Published: October 2012

PurposeThis paper aims to describe the experience of a secure learning disability service in participating in the national Shared Pathway pilot project in secure services.Design/methodology/approachSome background drivers to the project are explored as well as the experience of service users and staff who were involved in the pilot project. Recommendations on service‐wide implementation of the Shared Pathway are made.FindingsThe Shared Pathway will lead to considerable changes in practice. This will also have resource implications.Originality/valueThe paper shows that the Shared Pathway may be useful in ensuring evidence based outcomes are routinely used by clinicians in secure services in collaboration with patients. It may also clarify to patients what their role is in engaging in treatment that helps them in moving through secure services.
Human Labour is Associated with a Decline in Myometrial Chemokine Receptor Expression: The Role of Prostaglandins, Oxytocin and Cytokines
Authors: Hua Renyi , Pease James E. , Cheng Weiwei , Sooranna Suren R. , Viney Jonathan M. , Nelson Scott M. , Myatt Les , Bennett Philip R. , Johnson Mark R. 
Published: October 2012

ProblemHuman labour is an inflammatory process with a heavy infiltration of immune cells into the myometrium and cervix induced by local chemokine production. Myometrial cells also express chemokine receptors, but there is little information about their behaviour or function during pregnancy and labour.Method of StudyWe studied the behaviour of the receptors (CCR2, CXCR1 and CXCR2) for the CCL2 and CXCL8 in human myometrium, because both have been shown to be important in labour.ResultsWe found that there was a significant decline in the mRNA expression of all three receptors in the upper segment and a similar trend in the lower segment with the onset of term labour (TL). Chemokine receptor mRNA expression was increased by stretch, reduced by oxytocin and PGF2α acting via phospholipase C (PLC). CXCR2 declined with exposure to CXCL8, consistent with the negative relationship observed in labouring myometrial tissue. The mRNA changes were confirmed by western analysis and flow cytometry.ConclusionThese data show that myometrial chemokine receptor expression is reduced with the onset of term labour probably in response to the increased activity of chemokines, oxytocin and PGF2α.
Ocean acidification increases the toxicity of contaminated sediments
Authors: Roberts David A. , Birchenough Silvana N. R. , Lewis Ceri , Sanders Matthew B. , Bolam Thi , Sheahan Dave 
Published: October 2012

AbstractOcean acidification (OA) may alter the behaviour of sediment‐bound metals, modifying their bioavailability and thus toxicity. We provide the first experimental test of this hypothesis with the amphipod Corophium volutator. Amphipods were exposed to two test sediments, one with relatively high metals concentrations (Σmetals 239 mg kg−1) and a reference sediment with lower contamination (Σmetals 82 mg kg−1) under conditions that mimic current and projected conditions of OA (390–1140 μatm pCO2). Survival and DNA damage was measured in the amphipods, whereas the flux of labile metals was measured in the sediment and water column (WC) using Diffusive Gradients in Thin‐films. The contaminated sediments became more acutely toxic to C. volutator under elevated pCO2 (1140 μatm). There was also a 2.7‐fold increase in DNA damage in amphipods exposed to the contaminated sediment at 750 μatm pCO2, as well as increased DNA damage in organisms exposed to the reference sediment, but only at 1140 μatm pCO2. The projected pCO2 concentrations increased the flux of nickel and zinc to labile states in the WC and pore water. However, the increase in metal flux at elevated pCO2 was equal between the reference and contaminated sediments or, occasionally, greater from reference sediments. Hence, the toxicological interaction between OA and contaminants could not be explained by e	ffects of pH on metal speciation. We propose that the additive physiological effects of OA and contaminants will be more important than changes in metal speciation in determining the responses of benthos to contaminated sediments under OA. Our data demonstrate clear potential for near‐future OA to increase the susceptibility of benthic ecosystems to contaminants. Environmental policy should consider contaminants within the context of changing environmental conditions. Specifically, sediment metals guidelines may need to be reevaluated to afford appropriate environmental protection under future conditions of OA.
Breast surgeons' perceptions and attitudes towards contralateral prophylactic mastectomy
Authors: Musiello Toni , Bornhammar Emelie , Saunders Christobel 
Published: October 2012

AbstractBackgroundThe rates of contralateral prophylactic mastectomy (CPM) are increasing worldwide. This study investigated Australian and New Zealand's breast surgeons' perceptions, knowledge and attitudes towards CPM, and explored if demographic characteristics of surgeons were associated with an increased tendency to recommend or perform CPM.MethodsA cross sectional research design was employed, with breast surgeons completing a self‐report questionnaire. The questionnaire collected information including surgeons' perceptions on CPM in their clinical practice, their attitudes and knowledge of CPM and surgeons' demographic information.Results Eighty‐one of 220 (37%) breast surgeons contacted via BreastSurgANZ participated in this study. Forty‐four per cent of surgeons perceived that the rates of CPMs they performed had increased over the last year. CPM rates were found to be unrelated to surgeons' age (P = 0.773) or gender (P = 0.941). The main reasons a surgeon recommended a CPM to patients included known BRCA+ mutation, family history of breast cancer and patient factors including fear and anxiety and a desire to avoid further breast cancer treatment.ConclusionsBreast surgeons perceived that rates of CPM were increasing in their own clinical practice. CPM rates were unrelated to surgeon demographics including age and gender. While surgeons are aware of the objective risk factors that make performing a CPM advisable, they also report taking into account subjective factors, including patient fear and anxiety and a desire for breast symmetry when recommending a CPM.
Non-Parametric Survival Analysis of Infectious Disease Data
Authors: Kenah Eben 
Published: October 2012

SummaryThe paper develops non-parametric methods based on contact intervals for the analysis of infectious disease data. The contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j, where we define infectious contact as a contact sufficient to infect a susceptible individual. The hazard function of the contact interval distribution equals the hazard of infectious contact from i to j, so it provides a summary of the evolution of infectiousness over time. When who infects whom is observed, the Nelson–Aalen estimator produces an unbiased estimate of the cumulative hazard function of the contact interval distribution. When who infects whom is not observed, we use an expectation–maximization algorithm to average the Nelson–Aalen estimates from all possible combinations of who infected whom consistent with the observed data. This converges to a non-parametric maximum likelihood estimate of the cumulative hazard function that we call the marginal Nelson–Aalen estimate. We study the behaviour of these methods in simulations and use them to analyse household surveillance data from the 2009 influenza A(H1N1) pandemic.
THE COMBINED INTRAVAGINAL SLING AND TUCK OPERATION. AN AMBULATORY PROCEDURE FOR CURE OF STRESS AND URGE INCONTINENCE
Authors: Petros Peter E. Papa , Ulmsten Ulf I. 
Published: October 2012

Abstract Thirty patients with symptoms and signs of stress and urge incontinence were treated with a Combined Intravaginal Sling and Tuck procedure. Primarily, only the first part of the procedure, the Sling operation was undertaken. This procedure creates an artificial pubourethral ligament which is achieved by controlled deposition of collagen around a retropubically implanted, removable, 0.5 cm wide Mersilene tape, inserted through a special tunneler. This part, stage 1 of the combined surgical procedure is mainly performed under local anaesthesia without postoperative catheterization, and early return to work. Urgency symptoms were cured simultaneously with the stress symptoms.The 50% success rate of the sling procedure was improved to 82% when the second part (stage 2) of this operation was undertaken. This procedure, the “Tuck” operation, tightens the suburethral vagina. The results of the combined procedure indicate that both an intact pubourethral ligament and tight suburethral vagina are equally important for cure as proposed in the Integral Theory of Female Urinary Incontinence.
Candidates for detecting exoplanetary radio emissions generated by magnetosphere—ionosphere coupling
Authors: Nichols J. D. 
Published: October 2012

Abstract
In this Letter we consider the magnetosphere—ionosphere (M—I) coupling at Jupiter-like exoplanets with internal plasma sources such as volcanic moons, and we have determined the best candidates for detection of these radio emissions by estimating the maximum spectral flux density expected from planets orbiting stars within 25 pc using data listed in the NASA/IPAC/NExScI Star and Exoplanet Database (NStED). In total we identify 91 potential targets, of which 40 already host planets and 51 have stellar X-ray luminosity over 100 times the solar value. In general, we find that higher planetary field strength, combined with larger rotation rate, higher stellar XUV luminosity and lower stellar wind dynamic pressure, results in higher radio power. The top two targets that host planets are ε Eri and HIP 85523, and the top two targets that have X-ray luminosity over 100 times the solar value are CPD—28 332 and FF And.
Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice
Authors: Shi Da , Xu Su , Waddell Jaylyn , Scafidi Susanna , Roys Steven , Gullapalli Rao P. , McKenna Mary C. 
Published: October 2012

AbstractFragile X syndrome (FXS) is the most common form of inherited mental retardation and is studied in the Fmr1 knockout (KO) mouse, which models both the anatomical and behavioral changes observed in FXS patients. In vitro studies have shown many alterations in synaptic plasticity and increased density of immature dendritic spines in the hippocampus, a region involved in learning and memory. In this study, magnetic resonance imaging (MRI) and 1H magnetic resonance spectroscopy (MRS) were used to determine in vivo longitudinal changes in volume and metabolites in the hippocampus during the critical period of early myelination and synaptogenesis at post‐natal days (PND) 18, 21, and 30 in Fmr1 KO mice compared with wild‐type (WT) controls. MRI demonstrated an increase in volume of the hippocampus in the Fmr1 KO mouse compared with controls. MRS revealed significant developmental changes in the ratios of hippocampal metabolites N‐acetylaspartate (NAA), myo‐inositol (Ins), and taurine to total creatine (tCr) in Fmr1 KO mice compared with WT controls. Ins was decreased at PND 30, and taurine was increased at all ages studied in Fmr1 KO mice compared with controls. An imbalance of brain metabolites in the hippocampus of Fmr1 KO mice during the critical developmental period of synaptogenesis and early myelination could have long‐lasting effects that adversely affect brain development and contribute to ongoing alterations in brain function.
Structural basis for selective GABA binding in bacterial pathogens
Authors: Planamente Sara , Mondy Samuel , Hommais Florence , Vigouroux Armelle , Moréra Solange , Faure Denis 
Published: October 2012

SummaryGABA acts as an intercellular signal in eukaryotes and as an interspecies signal in host–microbe interactions. Structural characteristics of selective eukaryotic GABA receptors and bacterial GABA sensors are unknown. Here, we identified the selective GABA‐binding protein, called Atu4243, in the plant pathogen Agrobacterium tumefaciens. A constructed atu4243 mutant was affected in GABA transport and in expression of the GABA‐regulated functions, including aggressiveness on two plant hosts and degradation of the quorum‐sensing signal. The GABA‐bound Atu4243 structure at 1.28 Å reveals that GABA adopts a conformation never observed so far and interacts with two key residues, Arg203 and Asp226 of which the role in GABA binding and GABA signalling in Agrobacterium has been validated using appropriate mutants. The conformational GABA‐analogue trans‐4‐aminocrotonic acid (TACA) antagonizes GABA activity, suggesting structural similarities between the binding sites of the bacterial sensor Atu4243 and mammalian GABAC receptors. Exploration of genomic databases reveals Atu4243 orthologues in several pathogenic and symbiotic proteobacteria, such as Rhizobium, Azospirillum, Burkholderia and Pseudomonas. Thus, this study establishes a structural basis for selective GABA sensors and offers opportunities for deciphering the role of the GABA‐mediated communication in several host–pathogen interactions.