bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online streaming feature selection for high-dimensional small-sample data
Authors: Gong Kuangfeng , Li Guohe , Guo Lingyun , Lin Yaojin 
Published: July 2024

Abstract

Within the domain of high-dimensional small-sample data classification tasks, there are several significant challenges. The feature space of samples typically has high dimensionality, and the features of samples may be extracted sequentially. In addition, the distribution of data categories is imbalanced. For this purpose, a novel online feature selection algorithm specifically designed for this scenario is presented in this paper. First, an adaptive neighborhood relation is proposed, which is based on class density, and the distribution of the target sample's category is fully utilized. Second, a neighborhood consistency metric is defined based on the proposed neighborhood relation. Moreover, the proposed online feature selection algorithm consists of three main phases: significance judgment, correlation analysis, and redundancy update. Comprehensive experimental studies on 12 datasets illustrate that our method significantly enhances the prediction of minority class samples compared to several popular online streaming feature selection algorithms.
Mesh-reinforced Vaseline-assisted graphene transfer compatible with industrial automation operations
Authors: Li Xuesong , Guo Xiaomeng , Qing Fangzhu , Liu Wei , Liu Yaxin , Liang Yiji , Li Runlai , li Pingjian , Tu Xiaoming , Liu Chunlin , Li Zhancheng , Wang Huaipeng , Ran Yutong , Shi Haofei , Xie Dan , Zhu Hongwei , Niu Xiaobin , Zhao Zejia , Shen Changqing 
Published: July 2024

Abstract

The growth of graphene on Cu via chemical vapor deposition has been well established for producing large-area high-quality graphene films, with graphene transfer to other substrate as an essential step for its applications. Various transfer techniques have been studied, but real industrial automation operations have seldom been developed. We report a mesh-reinforced Vaseline-assisted transfer method, which utilizes a mesh embedded Vaseline structure, similar to reinforced concrete, as a carrier film for graphene transfer. Vaseline acts as an adhesive layer that preserves graphene’s integrity and can be easily removed, while the mesh reinforcement ensures the structure self-support and therefore easy processing, compatible with industrial automation operations. Successful graphene transfers onto SiO2/Si wafers and curved surfaces with good integrity and cleanliness are demonstrated and an automated graphene transfer production line is also presented, highlighting the potential for mass production and applicability to other two-dimensional materials and thin films as well.
South African patenting trends based on the European Patent Office (EPO)’s worldwide patent statistical database (PATSTAT)
Authors: Mafata Mpho , Linde Ian van der 
Published: July 2024

Abstract

This study describes South African (SA) patenting trends based on data from the European Patent Office’s (EPO) patent statistics (PATSTAT) database. We aimed to answer; where, what, and with whom are South Africans patenting over the past 22 years (i.e., 2000 to 2021). By counting the number of patent families and applications per office/authority we described the intensity in patenting. Counting the patents and technology types indicated the focus areas of these patents. We found that the South African patenting landscape is predominantly domestic, with a trend towards otherwise filing at the major patenting offices (i.e., the United States patenting office – USPTO and the EPO). Generally, there has been a decline in filings at international offices since peaking in 2010. Most granted patents were in human necessities (medicine and agriculture) and physical/chemical processes (petroleum). SA inventors collaborated mainly with US, German, and United Kingdom inventors. This may indicate financial non-viability of South African patent filing/ownership (where inventors relinquish their rights for financial gain), outsourcing of South African inventive capacity, or centralised filings by international firms with headquarters outside of SA. The latter may be part of the larger matter of emigration of South African talent/inventive capacity.
An integrated framework for waterfront development to recognize nature-based solutions (NBS) in urban areas: evaluating the condition of two projects in Bangladesh
Authors: Bin Zaman K. M. Ulil Amor , Tumpa Rifat Tabassoom , Chowdhooree Imon 
Published: July 2024

ABSTRACT

Nature-based solutions (NBS) often suggest improving the degraded urban environment through the implementation of projects for revitalizing water bodies and adjacent areas. Among various concepts of developing waterfront urban spaces, ‘water sensitive urban design (WSUD)’ asks for integrated design and management of urban water resources and water cycle, following a holistic approach. This research proposes a framework that assimilates the components of WSUD with the concept of ‘integrated urban water management (IUWM)’ that mainly focuses on governance, management, and stakeholders' engagement. This integrated approach emphasizes the need for developing a holistic framework for the management of planning and design of waterfront development projects. The framework includes detailed criteria for water sensitive approach and acts as a holistic checklist for evaluating or designing waterfront development projects. Such comprehensive guidelines that includes planning, governance, and design challenges are rare in the current body of literature. To test the framework, the research conducts a comparative study among two waterfront projects in Bangladesh and through a scored evaluation based on the proposed framework, reveals the lack of water sensitive planning, design and management processes of the projects, which has narrowed down the scope and the opportunities of practicing NBS through reviving lost urban waterbodies.
Optimizing Prostate Imaging Practices in Saudi Arabian Hospitals: A Comprehensive Analysis of PI-RADS Compliance in Multiparametric MRI
Authors: Alshuhri Mohammed S. , Alhulail Ahmad A. , Alqahtani Abdullalh G. M. , Madkhali Yahia , Alshehri Abdullah M. , Alghuraybi Rakan A. , Alqahtani Saeed , BinMhusien Meshari Ali , Alqahtani Mansour , Qaisi Abdulrahman 
Published: July 2024

Background:
Prostate cancer, a significant contributor to male cancer mortality globally, demands improved diagnostic strategies. In Saudi Arabia, where the
incidence is expected to double, this study assessed the compliance of multiparametric MRI (mpMRI) practices with Prostate Imaging-Reporting
and Data System version 2 (PI-RADS v2) guidelines across diverse healthcare institutions.

Methods:
A survey was distributed to the radiology departments of all tertiary referral hospitals in Saudi Arabia (n=60) to assess their compliance with the
technical specifications outlined in PI-RADS v2. Statistical analysis included chi-square, Fisher exact, ANOVA, and Student t-tests to examine the
collected data;

Results:
The study revealed an overall commendable compliance rate of 95.23%. However, significant variations were observed in technical parameters,
particularly between 1.5 Tesla and 3 Tesla scanners and tertiary versus non-tertiary hospitals. Notable adherence in certain sequences contrasted
with discrepancies in T2-weighted and diffusion-weighted imaging parameters

Conclusion:
These findings underscore the need for nuanced approaches to optimize prostate imaging protocols, considering field strength and institutional
differences. The study contributes to the ongoing refinement of standardized mpMRI practices, aiming to enhance diagnostic accuracy and improve
clinical outcomes in prostate cancer.
N,N-Disubstituted 4-Sulfamoylbenzoic Acid Derivatives as Inhibitors of Cytosolic Phospholipase A2α: Synthesis, Aqueous Solubility, and Activity in a Vesicle and a Whole Blood Assay
Authors: Borecki Daniel , Vilsendorf Imke Meyer zu , Fabian Jörg , Lehr Matthias 
Published: July 2024

Background:
Cytosolic phospholipase A2α (cPLA2α) is the key enzyme that initiates the
arachidonic acid cascade through which pro-inflammatory lipid mediators can be formed. Therefore,
cPLA2α is considered an interesting target for the development of anti-inflammatory drugs.
Although several effective inhibitors of the enzyme have been developed, none of them has yet
reached clinical application.

Objective:
Recently, we have prepared new 4-sulfamoylbenzoic acid derivatives based on a cPLA2α
inhibitor found in a ligand-based virtual screening. The most effective of these compounds were
now subjected to further variations in which the substitution pattern on the sulfamoyl nitrogen atom
was changed.

Methods:
The new compounds were tested in vitro in a vesicle assay for cPLA2α inhibition as well
as for their water solubility, metabolic stability, and selectivity towards related enzymes. In addition,
they were evaluated ex vivo in a whole blood assay in which metabolites of the arachidonic
acid cascade formed after activation of cPLA2α were quantified using a combined online dilution/
online solid phase extraction HPLC-MS method.

Results:
Inhibitors with submicromolar inhibitory in vitro potency were found with favourable
water solubility and selectivity. However, their efficacy did not match that of the highly effective,
known, structurally related cPLA2α inhibitor giripladib, which was also tested as a reference. One
advantage of some of the new compounds compared to giripladib was their significantly improved
water solubility. When analyzing the substances in the ex vivo whole blood assay, it was found that
the obtained inhibition data correlated better with the in vivo results when the phorbol ester 12-Otetradecanoylphorbol-
13-acetate was used for activation of the enzyme in the blood cells instead of
the calcium ionophore A23187.

Conclusion:
New compounds with good activity towards cPLA2α and reasonable physicochemical
properties were identified. Overall, the results obtained could be helpful in the development of clinically
applicable inhibitors of this enzyme.
Efficacy of Semaglutide in Reactive Hypoglycemia Related to Dumping
Syndrome after Bariatric Surgery
Authors: Fiore Angelo , Gaetano Santoro , Ausilia Lombardo , Federica Spitali , Giulia Sceusa , Damiano Gullo 
Published: July 2024

Introduction:
Postprandial hypoglycemia induced by Dumping Syndrome (DS) represents
a side effect of bariatric surgery linked to glucose-dependent hyperinsulinemia, which
can cause serious symptoms 2-3 hours after the meal hypoglycemia. This clinical case shows
the effectiveness of semaglutide, a long-acting GLP1 receptor agonist, in one patient previously
subjected to gastric bypass (GBP), with persistent late postprandial hypoglycaemic symptoms
occurring after surgery.

Case Report::
A female patient, 31 years old, subjected to GBP 10 years earlier, with the diagnosis
of diabetes, was admitted to our unit for persistent post-prandial reactive hypoglycemia,
confirmed by Flash Glucose Monitoring (FGM) FreeStyle. The patient was intolerant to metformin,
had been treated with acarbose with poor results. HbA1c 7.9%. Acarbose was suspended,
and semaglutide was started sc at increasing doses, 0.25 mg/week for 1 month and subsequently
0.5 mg/week. After the first few weeks, symptoms of DS were significantly reduced
with improvement of the daily glycemic profile and disappearance of hypoglycemic events. The
time-below range, time spent with blood glucose <70 mg/dl, decreased by 12% to 4% during
treatment with semaglutide 0.25 mg/week, up to 1% with a dose of 0.5 mg/week. The effect of
the drug on reducing hypoglycemic episodes was persistent for up to 8 months.

Conclusion::
Treatment of post-bariatric reactive hypoglycemia includes nutritional therapy, the
use of glucosidase inhibitors, and somatostatin analogues. The use of short-acting GLP-1RA
analogues has also recently been reported. In our patient, therapy with semaglutide s.c. significantly
reduced episodes of reactive hypoglycemia with an improvement in the quality of life.
Recent Advances in Heterogeneously Catalyzed Acceptorless Dehydrogenation of Alcohols to Carbonyl Derivatives and N-heterocyclic Compounds
Authors: Bordoloi Krisangi , Baruah Jyotishma , Gogoi Bibekananda , Das Pankaj 
Published: July 2024

:
Oxidation of alcohols in an oxidant-free condition, commonly known as the acceptorless dehydrogenation (AD) reaction, has recently emerged as
one of the widely used processes in synthetic organic chemistry. Alcohol acts as an excellent chemical precursor that produces a variety of
dehydrogenated value-added products such as carbonyls, acids, acetals, and several coupling products, followed by the concomitant evolution of
molecular hydrogen gas. AD reaction of alcohol, therefore, can be considered as a vital reaction for the hydrogen economy using alcohols as a
liquid hydrogen carrier. Over the past decade, the growing importance of AD reactions has set the way for the continuous development of various
homogeneous and heterogeneous catalytic systems. With the advantage of reusability and recyclability, heterogeneous catalysts have now become
more promising and significant in the catalytic domain. This review aims to make an overview of the transition metal-based heterogeneous
catalytic system of acceptorless alcohol dehydrogenation reaction reported till December, 2023.
What are Proteome Atlases good for?
Authors: Kumar Yadav Amit , Aggarwal Suruchi 
Published: July 2024

:
The technological advances in mass spectrometry and associated computational tools have enabled the development of proteome atlases and
comprehensive catalogs of proteome snapshots that have gradually transformed biomedical research. These proteome catalogs in specific
biological contexts, which focused initially on model organisms, have now expanded their scope to encompass diverse organisms, tissues, and
experimental conditions. These atlases, such as the Human Protein Atlas (HPA), Peptide Atlas, and Global Proteome Machine Database
(GPMDB), etc. provide invaluable insights into protein expression, subcellular localization, interactions, modifications, and functions. They aid in
understanding biological processes, identifying disease biomarkers, and discovering novel therapeutic targets. Despite their potential, proteome
atlases face challenges like data completeness, integration with other omics data, and ethical considerations. Addressing these challenges is vital
for further progress. Proteome atlases serve as indispensable resources, driving biomedical discovery and innovation.
Microwave Revolution: Transforming Biomedical Synthesis for Tissue Engineering Advancements
Authors: Sridhar Srikruthi Kunigal , Bhavani Penmetsa Durga , Noothi Sadhana , Gajula Lakshmi Radhika , Goudanavar Prakash , Gowthami Buduru , Naveen Nimbagal Raghavendra 
Published: July 2024

:
Microwave-Assisted Synthesis (MAS) has emerged as a groundbreaking technique revolutionizing
the field of biomedical and tissue engineering. This review aims to explore the fundamental
principles, techniques, and applications of MAS in these domains. Beginning with an overview
highlighting its significance, we delve into the basic principles, mechanisms, and comparative
analysis with conventional methods. Subsequently, the review explores MAS techniques in biomaterial
synthesis, tissue scaffold fabrication, functionalization, and nanomaterial synthesis, along
with their role in drug delivery systems. We then examine its diverse applications, including rapid
biomaterial synthesis, property tailoring, biocompatibility enhancements, and tissue regeneration
strategies. Furthermore, we address the challenges and future perspectives, focusing on safety considerations,
understanding cellular responses, integration with advanced technologies, regulatory
aspects, and future directions. This comprehensive review underscores MAS as a transformative
tool driving innovations in biomedical research and therapeutic applications.
Patient Safety Incident Reporting and Learning Guidelines Implemented by Health Care Professionals in Specialized Care Units: Scoping Review
Authors: Gqaleni Tusiwe Mabel , Mkhize Sipho Wellington , Chironda Geldine 
Published: July 2024

Background
Implementing Patient Safety Incident Reporting and Learning (PSIRL) guidelines is critical in guiding clinical practice and improving clinical outcomes in specialized care units (SCUs). There is limited research on the evidence of the implemented PSIRL guidelines in SCUs at the global level.

Objective
This review aims to map the evidence of PSIRL guidelines implemented by health care professionals in specialized care units globally.

Methods
A scoping review methodology, according to Joanna Briggs Institute, was adopted. The eligibility criteria were guided by the Population, Concept, and Context (PCC) framework, with the Population including health care professionals, the Concept including PSIRL guidelines, and the Context including specialized units globally. Papers written in English were searched from relevant databases and search engines. The PRISMA-ScR (Preferred Reporting Items for Scoping Reviews and Meta-Analyses extension for Scoping Reviews) checklist for used.

Results
The 13 selected studies were published from 2003 to 2023. Most articles are from the Netherlands and Switzerland (n=3), followed by South Africa (n=2). The nature of implemented PSIRL guidelines was computer-based (n=11) and paper-based incident reporting (n=2). The reporting system was intended for all the health care professionals within the specialized units, focusing on patients, staff members, and families. The outcomes of implemented incident reporting guidelines were positive, as evidenced by improved reporting of incidents, including medication errors (n=8) and decreased rate of incidents and errors (n=4). Furthermore, 1 study showed no change (n=1) in implementing the incident reporting guidelines.

Conclusions
The implementation of reporting of patient safety incidents (PSIs) in specialized units started to be reported around 2002; however, the frequency of yearly publications remains very low. Although some specialized units are still using multifaceted interventions and paper reporting systems in reporting PSIs, the implementation of electronic and computer-based reporting systems is gaining momentum. The effective implementation of an electronic-based reporting system should extend into other units beyond critical care units, as it increases the reporting of PSIs, reducing time to make an informed reporting of PSIs and immediate accessibility to information when needed for analysis. The evidence on the implementation of PSI reporting guidelines in SCUs comes from 5 different continents (Asia, Africa, Australia, Europe, and North America). However, the number identified for certain countries within each continent is very minimal.
Composition and zoogeography of marine-estuarine fish from a lagoon system in a temperate-tropical transition zone of the Eastern Pacific
Authors: Rábago-Quiroz Carlos Hiram , González-Acosta Adrián Felipe , Ruiz-Campos Gorgonio , Franco-López Jonathan , García-Borbón Juan Antonio , Magaña Joaquín D. 
Published: July 2024

We present an updated systematic checklist of fishes from the Bahía Magdalena-Almejas lagoon system (Mexico), including notes on taxonomy, zoogeography, and conservation status, supported by field samplings and the critical review of published and online data. The ichthyofauna is composed by 2 classes, 30 orders, 104 families, 240 genera and 416 species, mainly represented by the class Actinopterygii. Zoogeographically, the fishes showed highest affinity to the San Diego (87.2%), Cortez (81.4%) and Mexican (70%) provinces, reflecting the ancient relationship between the Californian and Tropical Eastern Pacific regions and the existence of a transitional zone in the Baja California Peninsula for fish assemblages from boreal-temperate and warm-tropical derivation, standing out the presence of the endemic Paraclinus magdalenae. The 91% of the ichthyofauna is included by the IUCN Red List as Lower Concern, Data Deficient and Not Evaluated, while Holacanthus clarionensis and Hippocampus ingens, are under Special Protection by the Mexican regulation. Ecologically, 233 species are marine-euryhaline and 177 marine-stenohaline, which preferentially inhabit soft (57%) and rocky (27.5%) bottoms; most species are demersal (60%), benthic (25%) and pelagic (14.4%). The updated checklist could improve the design and implementation of effective fishing regulation strategies and conservation programs for fishes inhabiting this coastal ecosystem.
TRANSLATION TECHNIQUES OF RACIAL SLURS IN THE MOVIE '42' SUBTITLES
Authors: Nugroho Muhammad Aprianto Budie , Agustiana Vina , Budi Farid Faqih Kusuma 
Published: July 2024

This research aimed to classify racism slurs translation techniques in the subtitles of the movie entitled 42 made by professional (Netflix) and fan subtitlers (Movieku). It applied a qualitative approach with a case study design. For analyzing the data, it used document analysis with the objects the movie transcripts and subtitles. The data were analyzed by using the theory of translation technique from Molina and Albir (2002). From the total 192 data (96 for each category) there were found 11 types of translation techniques applied, i.e.: amplification, compensation, description, established equivalent, literal translation, linguistic compression,
modulation, naturalization borrowing, particularization, pure borrowing, and reduction. The data show that both professional and fansub use more than one type of translation techniques that can be grouped into single (22.4%), duplet (58.8%), triplet (18.2%), and quartet group (0.5%). The frequency of occurrences of each group of the translation techniques in the professional subtitles are 20 times or 20.83% for single, 50 (52.08%) for duplet, 25 (26.04%) for triplet, and only 1 (1.04%) for quartet. In fansubs, there are 23 occurrences or 23.96% for single, 63 (65.62%) for duplet, 10 (10.41%) for triplet, and none for quartet. The result of this research is expected to be a reference for the other research with the same topic.
Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries
Authors: Mandla Ravi , Schroeder Philip H. , Florez Jose C. , Mercader Josep M. , Leong Aaron 
Published: July 2024

OBJECTIVE
Individuals with diabetes who carry genetic variants that lower hemoglobin A1c (HbA1c) independently of glycemia may have higher real, but undetected, hyperglycemia compared with those without these variants despite achieving similar HbA1c targets, potentially placing them at greater risk for diabetes-related complications. We sought to determine whether these genetic variants, aggregated in a polygenic score, and the large-effect African ancestry–specific missense variant in G6PD (rs1050828) that lower HbA1c were associated with higher retinopathy risk.

RESEARCH DESIGN AND METHODS
Using data from 29,828 type 2 diabetes cases of genetically inferred African American/African British and European ancestries, we calculated ancestry-specific nonglycemic HbA1c polygenic scores (ngA1cPS) composed of 122 variants associated with HbA1c at genome-wide significance, but not with glucose. We tested the association of the ngA1cPS and the G6PD variant with retinopathy, adjusting for measured HbA1c and retinopathy risk factors.

RESULTS
Participants in the bottom quintile of the ngA1cPS showed between 20% and 50% higher retinopathy prevalence, compared with those above this quintile, despite similar levels of measured HbA1c. The adjusted meta-analytic odds ratio for the bottom quintile was 1.31 (95% CI 1.0, 1.73; P = 0.05) in African ancestry and 1.31 (95% CI 1.15, 1.50; P = 6.5 × 10−5) in European ancestry. Among individuals of African ancestry with HbA1c below 7%, retinopathy prevalence was higher in individuals below, compared with above, the 50th percentile of the ngA1cPS regardless of sex or G6PD carrier status.

CONCLUSIONS
Genetic effects need to be considered to personalize HbA1c targets and improve outcomes of people with diabetes from diverse ancestries.