bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Recent Trend in Esophageal Adenocarcinoma Incidence and Mortality Using Comparative Simulation Modeling
Authors: Kong Chung Yin , Kroep Sonja , Curtius Kit , Hazelton William D. , Jeon Jihyoun , Meza Rafael , Heberle Curtis R. , Miller Melecia C. , Choi Sung Eun , Lansdorp-Vogelaar Iris , van Ballegooijen Marjolein , Feuer Eric J. , Inadomi John M. , Hur Chin , Luebeck E. Georg 
Published: April 2014

Abstract
Background: The incidence of esophageal adenocarcinoma (EAC) has increased five-fold in the United States since 1975. The aim of our study was to estimate future U.S. EAC incidence and mortality and to shed light on the potential drivers in the disease process that are conduits for the dramatic increase in EAC incidence.
Methods: A consortium of three research groups calibrated independent mathematical models to clinical and epidemiologic data including EAC incidence from the Surveillance, Epidemiology, and End Results (SEER 9) registry from 1975 to 2010. We then used a comparative modeling approach to project EAC incidence and mortality to year 2030.
Results: Importantly, all three models identified birth cohort trends affecting cancer progression as a major driver of the observed increases in EAC incidence and mortality. All models predict that incidence and mortality rates will continue to increase until 2030 but with a plateauing trend for recent male cohorts. The predicted ranges of incidence and mortality rates (cases per 100,000 person years) in 2030 are 8.4 to 10.1 and 5.4 to 7.4, respectively, for males, and 1.3 to 1.8 and 0.9 to 1.2 for females. Estimates of cumulative cause-specific EAC deaths between both sexes for years 2011 to 2030 range between 142,300 and 186,298, almost double the number of deaths in the past 20 years.
Conclusions: Through comparative modeling, the projected increases in EAC cases and deaths represent a critical public health concern that warrants attention from cancer control planners to prepare potential interventions.
Impact: Quantifying this burden of disease will aid health policy makers to plan appropriate cancer control measures. Cancer Epidemiol Biomarkers Prev; 23(6); 997–1006. ©2014 AACR.
Circulating 25-hydroxyvitamin D Levels and Prognosis among Cancer Patients: A Systematic Review
Authors: Toriola Adetunji T. , Nguyen Nhi , Scheitler-Ring Kristen , Colditz Graham A. 
Published: April 2014

Abstract
Circulating 25-hydroxyvitamin D (25-OHD) is associated with a reduction in risk of some cancers, but its association with prognosis among patients with cancer is poorly understood. In view of the increasing number of cancer survivors in the United States and the high prevalence of vitamin D deficiency among patients with cancer, an evaluation of the role of circulating 25-OHD in prognosis among patients with cancer is essential. We conducted a systematic review of studies published in the following databases—PubMed, OvidSP, BioMed Central, EMBASE, and Scopus till September 2013 using the following search terms: “vitamin D,” “25-hydroxyvitamin D,” “calcidiol,” “cancer,” “survival,” “mortality,” and “prognosis.” Our search yielded 1,397 articles. From the 1,397 articles, we identified 26 studies that evaluated the associations of circulating 25-OHD with prognosis among patients with cancer. Evidence suggests that circulating 25-OHD levels may be associated with better prognosis in patients with breast and colorectal cancer, but there is a paucity of information on its association with prognosis in other cancers. This review highlights the need for further studies evaluating the role of vitamin D in prognosis among patients with cancer. Cancer Epidemiol Biomarkers Prev; 23(6); 917–33. ©2014 AACR.
Comparison of Statistical Analysis Plans in Randomize-All Phase III Trials with a Predictive Biomarker
Authors: Matsui Shigeyuki , Choai Yuki , Nonaka Takahiro 
Published: April 2014

Abstract
When there are no compelling biologic or early trial data for a candidate predictive biomarker with regard to its ability to predict the effect of an anticancer treatment at the initiation of definitive phase III trials, it is generally reasonable to include all patients as eligible for randomization but to plan for a prospective subgroup analysis based on the biomarker. We assessed such statistical analysis plans, fixed-sequence, fallback, and treatment-by-biomarker interaction approaches, in terms of the probability of asserting treatment efficacy for either the overall patient population or a biomarker-positive subpopulation of patients. If there was some evidence that the treatment would work better in the biomarker-positive subgroup than the biomarker-negative subgroup, then the fixed-sequence approaches would be favored, whereas if evidence was weak that there would be much difference in responsiveness between the two subgroups, then the fallback approach would be favored. If there was substantial uncertainty in the difference in treatment effects between the two subgroups, the treatment-by-biomarker interaction approach could be a reasonable choice as this approach generally provided a high probability of asserting treatment efficacy for the right patient population under homogeneous treatment effects and a qualitative interaction over biomarker-based subgroups. Clin Cancer Res; 20(11); 2820–30. ©2014 AACR.
Phase II Results of Dovitinib (TKI258) in Patients with Metastatic Renal Cell Cancer
Authors: Escudier Bernard , Grünwald Viktor , Ravaud Alain , Ou Yen-Chuan , Castellano Daniel , Lin Chia-Chi , Gschwend Jürgen E. , Harzstark Andrea , Beall Sarah , Pirotta Nicoletta , Squires Matthew , Shi Michael , Angevin Eric 
Published: April 2014

Abstract
Purpose: Fibroblast growth factor (FGF) signaling regulates tumor growth and vascularization and partly mediates antiangiogenic escape from VEGF receptor (VEGFR) inhibitors. Dovitinib (TKI258) is a tyrosine kinase inhibitor (TKI) that inhibits FGF receptor (FGFR), VEGFR, and platelet-derived growth factor receptor, which are known drivers of antiangiogenic escape, angiogenesis, and tumor growth in renal cell carcinoma (RCC).
Experimental Design: Patients with advanced or metastatic RCC were treated with oral dovitinib 500 mg/day (5-days-on/2-days-off schedule). The study population was enriched for patients previously treated with a VEGFR TKI and an mTOR inhibitor.
Results: Of 67 patients enrolled, 55 patients (82.1%) were previously treated with ≥1 VEGFR TKI and ≥1 mTOR inhibitor (per-protocol efficacy set). The 8-week overall response rate and disease control rate in this population were 1.8% and 52.7%, respectively. Disease control rate during the entire study period was 56.4% (50.9% ≥4 months). Median progression-free survival and overall survival in the entire population were 3.7 and 11.8 months, respectively. Pharmacodynamic analyses demonstrated dovitinib-induced inhibition of VEGFR (as determined by increased levels of placental growth factor and decreased levels of soluble VEGFR2) and FGFR (as determined by increased FGF23 serum measures). The most frequently reported treatment-related adverse events of all grades included nausea (65.7%), diarrhea (62.7%), vomiting (61.2%), decreased appetite (47.8%), and fatigue (32.8%).
Conclusion: Dovitinib was shown to be an effective and tolerable therapy for patients with metastatic RCC who had progressed following treatment with VEGFR TKIs and mTOR inhibitors. Clin Cancer Res; 20(11); 3012–22. ©2014 AACR.
Safety and Efficacy of a Potential Treatment Algorithm by Using Manual Compression Repair and Ultrasound-Guided Thrombin Injection for the Management of Iatrogenic Femoral Artery Pseudoaneurysm in a Large Patient Cohort
Authors: Dzijan-Horn Marijana , Langwieser Nicolas , Groha Philipp , Bradaric Christian , Linhardt Maryam , Böttiger Corinna , Byrne Robert A. , Steppich Birgit , Koppara Tobias , Gödel Julia , Hadamitzky Martin , Ott Ilka , von Beckerath Nicolas , Kastrati Adnan , Laugwitz Karl-Ludwig , Ibrahim Tareq 
Published: April 2014

Background—
Because of the risk of associated complications, femoral pseudoaneurysm (PSA) formation implies further treatment. Ultrasound-guided thrombin injection (UGTI) is becoming the accepted gold standard, but manual compression (MC) represents an established treatment option including PSAs not feasible for UGTI. This study aims to assess our experience in PSA treatment using MC or UGTI according to a potential algorithm based on morphological properties in a large patient cohort.

Methods and Results—
Between January 2007 and January 2011, a total of 432 PSAs were diagnosed in 29091 consecutive patients (1.49%) undergoing femoral artery catheterization. When compressible, small PSAs (<20 mm), PSAs without clearly definable neck, PSAs directly adjacent to vessels, and PSAs with concomitant arteriovenous fistula were referred to MC (n=145, 34%). All other PSAs were treated by UGTI (n=287, 66%). Follow-up duplex scans were performed within 12 to 14 hours after manual compression therapy and within 4 to 6 hours after UGTI or by the next morning and were available for 428 patients (99.1%). The overall success rate of our institutional therapeutic approach was 97.2%, which was achieved by 178 MC- and 357 UGTI-procedures, respectively. Procedural complications occurred in 5 cases (1.4%) after UGTI and in 3 cases (1.7%) after MC, respectively. The treatment algorithm was not successful in 12 patients, whereas 2 PSAs (0.5%) were successfully excluded by implantation of a covered stent-graft, and 10 patients necessitated surgical intervention (2.3%), which was associated with a high complication rate (30%).

Conclusions—
The presented treatment algorithm facilitates effective and safe PSA elimination.
Incidence, Trends, and Predictors of Ischemic Stroke 30 Days After an Acute Myocardial Infarction
Authors: Kajermo Ulf , Ulvenstam Anders , Modica Angelo , Jernberg Tomas , Mooe Thomas 
Published: April 2014

Background and Purpose—
Ischemic stroke is a known complication of acute myocardial infarction (AMI). Treatment of AMI has undergone great changes in recent years. We aimed to investigate whether changes in treatment corresponded to a lower incidence of ischemic stroke and which factors predicted ischemic stroke after AMI.

Methods—
Data were taken from the Swedish Register of Information and Knowledge about Swedish Heart Intensive Care Admissions. Patients with their first registered AMI between 1998 and 2008 were included. To identify ischemic strokes, we used the Swedish national patient register. To study a potential trend in the incidence of ischemic stroke after AMI over time, we divided the patient population into 5 time periods. Event-free survival was studied by Kaplan–Meier analysis. Cox proportional hazards regression model was used to identify stroke predictors.

Results—

Of 173 233 patients with AMI, 3571 (2.1%) developed ischemic stroke within 30 days. The incidence of ischemic stroke was significantly lower during the years 2007 to 2008 compared with 1998 to 2000, with respective rates of 2.0% and 2.2% (
P
=0.02). Independent predictors of an increased risk of stroke were age, female sex, prior stroke, diabetes mellitus, atrial fibrillation, clinical signs of heart failure in hospital, ST-segment–elevation myocardial infarction, coronary artery bypass grafting, and angiotensin-converting enzyme inhibitor treatment at discharge. Percutaneous coronary intervention, fibrinolysis, acetylsalicylic acid, statins, and P2Y12 inhibitors were predictors of reduced risk of stroke.

Conclusions—
The incidence of ischemic stroke within 30 days of an AMI has decreased during the period 1998 to 2008. This decrease is associated with increased use of acetylsalicylic acid, P2Y12 inhibitors, statins, and percutaneous coronary intervention.
Two New Species of Neomarica Sprague (Trimezieae-Iridaceae) from Bahia State, Northeastern Brazil
Authors: GIL ANDRÉ DOS SANTOS BRAGANÇA , BITTRICH VOLKER , AMARAL MARIA DO CARMO ESTANISLAU DO 
Published: April 2014

Neomarica eburnea and N. floscella, two new species of Iridaceae (Trimezieae) from Bahia state (Northeastern Brazil) are here described. Illustrations, diagnostic comparisons with morphologically similar species and an identification key for the species of the genus occurring in Bahia state are presented. Neomarica eburnea and N. floscella, two new species of Iridaceae (Trimezieae) from Bahia state (Northeastern Brazil) are here described. Illustrations, diagnostic comparisons with morphologically similar species and an identification key for the species of the genus occurring in Bahia state are presented.
Madden–Julian Oscillation and the Winter Rainfall in Taiwan
Authors: Hung Chih-wen , Lin Ho-Jiunn , Hsu Huang-Hsiung 
Published: April 2014

Abstract
This study discusses major impacts of the Madden–Julian oscillation (MJO) on the winter (November–April) rainfall in Taiwan. The results show that Taiwan has more rainfall in MJO phases 3 and 4 (MJO convectively active phase in the Indian Ocean and the western part of the Maritime Continent), and less rainfall in phases 7 and 8 (the western Pacific warm pool area). Mechanisms associated with the MJO are suggested as follows. 1) The tropics to midlatitude wave train: when the MJO moves to the middle Indian Ocean, a Matsuno–Gill-type pattern is induced. The feature of this tropical atmospheric response to the MJO diabatic heating is a pair of upper-level anomalous anticyclones symmetric about the equator to the west of the heating. The northern anomalous anticyclone over the Arabian Sea and northern India induces a northeastward-propagating wave train to the midlatitudes. The wave pattern consists of a cyclonic anomaly centered at East Asia that enhances the winter rainfall in Taiwan. 2) Increase of moisture supply from the South China Sea: when the MJO convection approaches Sumatra and Java of the Maritime Continent, the eastward penetration of equatorial convection enhances a low-level southerly flow that transports the moisture northward to Taiwan and southern China. As a consequence, with the increase of moisture supply from the south, more winter monsoon rainfall is observed in Taiwan.
Comparison of Disdrometer and X-Band Mobile Radar Observations in Convective Precipitation
Authors: Kalina Evan A. , Friedrich Katja , Ellis Scott M. , Burgess Donald W. 
Published: April 2014

Abstract
Microphysical data from thunderstorms are sparse, yet they are essential to validate microphysical schemes in numerical models. Mobile, dual-polarization, X-band radars are capable of providing a wealth of data that include radar reflectivity, drop shape, and hydrometeor type. However, X-band radars suffer from beam attenuation in heavy rainfall and hail, which can be partially corrected with attenuation correction schemes. In this research, the authors compare surface disdrometer observations to results from a differential phase-based attenuation correction scheme. This scheme is applied to data recorded by the National Oceanic and Atmospheric Administration (NOAA) X-band dual-polarized (NOXP) mobile radar, which was deployed during the second Verification of the Origins of Rotation in Tornadoes Experiment (VORTEX2). Results are presented from five supercell thunderstorms and one squall line (183 min of data). The median disagreement (radar–disdrometer) in attenuation-corrected reflectivity Z and differential reflectivity ZDR is just 1.0 and 0.19 dB, respectively. However, two data subsets reveal much larger discrepancies in Z (ZDR): 5.8 (1.6) dB in a hailstorm and −13 (−0.61) dB when the radar signal quality index (SQI) is less than 0.8. The discrepancies are much smaller when disdrometer and S-band Weather Surveillance Radar-1988 Doppler (WSR-88D) Z are compared, with differences of −1.5 dB (hailstorm) and −0.66 dB (NOXP SQI &lt; 0.8). A comparison of the hydrometeor type retrieved from disdrometer and NOXP radar data is also presented, in which the same class is assigned 63% of the time.
Refsum’s Disease and Cochlear Implantation
Authors: Nogueira Claudia , Meehan Thomasina , O’Donoghue Gerard 
Published: April 2014

Objectives: The objective was to describe a case of bilateral cochlear implantation in a 59-year-old man with hearing and visual impairment due to Refsum’s disease. Method: A retrospective case review was performed. Results: After cochlear implantation, the patient demonstrated much improved audiometric performance and reported improved sound localization. Conclusions: Bilateral cochlear implantation is an important strategy in the improvement of hearing and quality of life in individuals with Refsum’s disease.
Simultaneous Labyrinthectomy With Cochlear Implantation in Patients With Bilateral Ménière’s Disease
Authors: MacKeith Samuel A. C. , Bottrill Ian D. , Ramsden James D. 
Published: April 2014

Objective: The development of second-side Ménière’s disease in the only remaining serviceable ear is difficult to treat. We describe an intervention to control disabling disease combining a labyrinthectomy and cochlear implant to restore hearing. Methods: Following a thorough preoperative assessment and consenting process, 2 patients underwent labyrinthectomy of the affected ear with simultaneous cochlear implantation. Results: Both patients achieved control of Ménière’s attacks with improved hearing rehabilitation. Oscillopsia was noted by both patients. Both patients were pleased to have undergone the treatment. Conclusion: Severe symptomatic second-side Ménière’s disease in the only hearing ear is uncommon. We report the successful treatment of 2 patients in this difficult management scenario, by simultaneous surgical labyrinthectomy and cochlear implantation. We propose this as a potential management strategy in this rare but complex group of patients in whom all less destructive measures have failed.
Randomized cross-over trial to investigate the efficacy of a two-week physiotherapy programme with repetitive exercises of cueing to reduce the severity of freezing of gait in patients with Parkinson’s disease
Authors: Fietzek Urban M , Schroeteler Frauke E , Ziegler Kerstin , Zwosta Jens , Ceballos-Baumann Andres O 
Published: April 2014

Objective: To investigate the efficacy of a two-week programme of repetitive exercise with cueing and movement strategies upon freezing of gait in people with Parkinson’s disease. Design: Randomized cross-over trial. Setting: Specialist clinic for Parkinson’s disease. Subjects: A total of 22 patients with Parkinson’s disease and freezing while other symptoms had favorably responded to dopaminergic treatment. Intervention: Patients were randomized into a four-week cross-over trial, and received either treatment (Group 1) or no treatment (Group 2) during Period 1, and switched during Period 2. Treatment consisted of a two-week programme during which the patients exercised cueing, and movement strategies together with a physiotherapist. Main measure: The primary outcome measure was a freezing score assessed from blinded and random ratings of video recordings. The secondary outcome measure was a patient-reported freezing questionnaire. Mean differences between the treatment periods (treatment arms) were evaluated for treatment (period) effects. Sums of treatment periods were evaluated for carry-over effects. Results: The programme led to a significant treatment effect in the freezing score of 3.0 improvement (95% confidence interval 0.9–5.0; p < 0.01). No carry-over or period effects were detected. The questionnaire revealed a period effect, so groups were compared after Period 1, where a significant difference was found (15.0 vs. 11.7; p < 0.05). Conclusions: The two-week physiotherapy programme reduced the severity of freezing in patients with Parkinson’s disease.
Ginsenoside Rg3 enhances radiosensitization of hypoxic oesophageal cancer cell lines through vascular endothelial growth factor and hypoxia inducible factor 1α
Authors: Ge Xiaolin , Zhen Fuxi , Yang Baixia , Yang Xi , Cai Jing , Zhang Chi , Zhang Sheng , Cao Yuandong , Ma Jianxin , Cheng Hongyan , Sun Xinchen 
Published: April 2014

Objective To determine if the pretreatment of hypoxic human oesophageal carcinoma cell lines (EC109, TE1 and KYSE170) with ginsenoside Rg3 (Rg3) increases their radiosensitivity to X-rays. Methods The growth inhibitory effect of different Rg3 concentrations was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. Radiation sensitivity was measured using a clone formation assay and flow cytometry was used to measure the effects of Rg3 on radiation-induced apoptosis. Western blot analysis was used to measure the effects of Rg3 on the levels of hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF). Results Rg3 inhibited EC109, TE1 and KYSE170 cell growth in a dose- and time-dependent manner. Pretreatment with 10 µmol/ml Rg3 increased EC109, TE1 and KYSE170 radiosensitivity. Rg3 plus radiation significantly increased the apoptosis rate compared with radiation alone. Rg3 also decreased VEGF and HIF-1α protein levels in EC109 cells in a dose-dependent manner. The combination of Rg3 and radiation increased the fragmentation of double-stranded DNA. Conclusion Rg3 enhanced the radiosensitivity of human oesophageal carcinoma cell lines cultured under hypoxic conditions possibly by downregulating VEGF and HIF-1α protein levels.
Classification of Olecranon Stress Fractures in Baseball Players
Authors: Furushima Kozo , Itoh Yoshiyasu , Iwabu Shohei , Yamamoto Yuzuru , Koga Ryuji , Shimizu Masaki 
Published: April 2014

Background: Although the onset mechanism of an olecranon stress fracture (OSF) due to a throwing disorder is believed to involve valgus extension overload, olecranon posteromedial impingement, or triceps traction force, this issue is still debated in the literature. Purpose: To establish a classification system for the different types of OSFs to improve diagnosis and clarify the onset mechanism. Study Design: Case series; Level of evidence, 4. Methods: A total of 200 baseball players (198 male, 2 female; mean age, 16.1 years; age range, 13-27 years) who were diagnosed with an OSF from January 1987 to July 2012 were studied. Combined disorders as well as the direction and form of the fracture line were analyzed on plain radiographs, computed tomography, and magnetic resonance imaging. Furthermore, the presence or absence of ulnar collateral ligament (UCL) injuries and avulsion fractures of the lower pole of the medial epicondyle was determined by imaging findings to calculate the combined percentage of OSFs. In addition, the prevalence of OSFs was evaluated among patients who were evaluated between April 2008 and March 2011 for throwing elbow disorders. Results: There were 5 types of OSFs identified in the new classification system: physeal, classic, transitional, sclerotic, and distal. The physeal type was further separated into stages 1 to 4 based on severity. The mean age for each type identified was as follows: physeal, 14.1 years; classic, 18.6 years; transitional, 16.9 years; sclerotic, 18.0 years; and distal, 19.6 years. A concomitant UCL injury and/or medial epicondyle avulsion fracture was diagnosed in 71% to 95% of cases, depending on the OSF type. Among baseball-related elbow disorders, the incidence of OSFs was 5.4%. Conclusion: This study presents a new classification system for the different types of OSFs based on the origin and direction of the fracture plane. This new system was strongly influenced by the age at symptom onset. Such information is essential for successful open reduction and internal fixation by ensuring that fixation pressure is perpendicular to the fracture plane, which will avoid the recurrence of stress fractures. In addition, the prevalence of UCL injuries suggests that it is a major risk factor for the development of OSFs.