bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alkaline‐Earth (Mg–Ba) Coordination Networks Built Around the Tris(dipicolinato)cerate(3–) Ion: Highly Hydrated Networks That Survive Dehydration
Authors: Elahi S. M. , Rajasekharan M. V. 
Published: December 2014

AbstractAlkaline‐earth (AE)/cerium(III)‐based heterometallic coordination compounds of the biologically important ligand dipicolinic acid (dipicH2), namely [Mg(H2O)6]2[Ce(dipic)3][Ce(dipic)2(H2O)3]·2H2O (1), [Ca3(H2O)12Ce2(dipic)6]·6H2O (2), [Sr3(H2O)16Ce2(dipic)6]·4H2O (3) and [Ba2(H2O)7Ce(dipic)3NO3]·H2O (4), have been obtained by the reduction of an aqueous solution of (NH4)2Ce(NO3)6·6H2O in the presence of dipicH2 and alkaline‐earth oxides or carbonates. This series demonstrates the role of AE ions in controlling the topology of coordination networks based on the [Ce(dipic)3]3– anion. Compound 1 is a zero‐dimensional ionic compound, the crystal structure of compound 2 is based on a mixed four‐connected 3D network, compound 3 presents ladder‐shaped chains running along a crystallographic axis, and layers of squeezed CeBa6 pentagonal pyramids interconnected by nitrates generate a mixed five‐ and six‐connected network in 4. A thermal analysis showed that all four compounds exhibit reversible water‐uptake capacity and the basic nature of the frameworks could be intact up to at least 120 °C.
Synthesis, Characterisation, and Electroluminescence Properties of N‐Coumarin Derivatives Containing Peripheral Triphenylamine
Authors: Kotchapadist Palita , Prachumrak Narid , Sunonnam Thitiya , Namuangruk Supawadee , Sudyoadsuk Taweesak , Keawin Tinnagon , Jungsuttiwong Siriporn , Promarak Vinich 
Published: December 2014

AbstractA series of N‐coumarin derivatives, namely CThnT and CThnCT (n = 1–2), containing triphenylamine or triphenylamine‐substituted carbazole as substituent were synthesised, and their structures were confirmed by MALDI‐TOF MS, and NMR and IR spectroscopy. Their optical, physical and electroluminescence properties as non‐doped solution‐processed light‐emitters for OLEDs were investigated. DSC, TGA, AFM and PL spectra revealed their good film‐forming properties, high thermal and morphological stability, and good photoluminescence characteristics. The double‐layer solution‐processed OLEDs (ITO/PEDOT:PSS/EML/BCP/LiF:Al) fabricated using CThnT and CThnCT as the emissive layer and BCP as the electron‐transporting and hole‐blocking layer, exhibited stable green to orange electroluminescence (λEL = 536–592 nm) with turn‐on voltages of 2.7–2.9 V and maximum luminance efficiencies up to 3.94 cd A–1 at 17.6 mA cm–2 (maximum power efficiency of 1.62 lm W–1).
Synthesis of Saturated Benzodioxepinone Analogues: Insight into the Importance of the Aromatic Ring Binding Motif for Marine Odorants
Authors: Plummer Christopher M. , Gericke Robert , Kraft Philip , Raynor Aaron , Froese Jordan , Hudlický Tomáš , Rook Trevor J. , Jones Oliver A. H. , Hügel Helmut M. 
Published: December 2014

AbstractAs part of our research exploring the influence of molecular variations of Calone 1951® on marine fragrance performance, we report the synthesis, crystal structures, and olfactory analysis of the first saturated benzodioxepinone analogues. By substitution of the aromatic moiety of the benzodioxepinone fragrance molecule with a saturated ring counterpart, we endeavoured to discover the molecular interactions of the aromatic and aliphatic rings with fragrance receptor sites, and also to shed light on any potential chiral interactions occurring within the receptor. Our results showed that an aromatic ring system is necessary for binding to the marine odour receptor(s), and that the addition of an alkene or methyl substituent has little effect on the low receptor affinity. However, a weak marine odour character was found for the 6‐methyl saturated derivatives, which could possibly be explained by superposition analysis of the respective structures, which were derived from X‐ray coordinates.
Isolation and Structure Elucidation of Hyperibine J [Revised Structure of Adhyperfirin (7‐Deprenyl‐13‐methylhyperforin)]: Synthesis of Hyperibone J
Authors: Mitsopoulou Kornilia P. , Vidali Veroniki P. , Maranti Anna , Couladouros Elias A. 
Published: December 2014

AbstractStructure elucidation of hyperibine J, a new polycyclic polyprenylated acylphloroglucinol isolated from Hypericum sp., was investigated. Molecular weight and spectroscopic data comparison with adhyperfirin (7‐deprenyl‐13‐methylhyperforin) declared a structure revision of the latter. Moreover, chemical transformation to hyperibone J confirmed its proposed structure and absolute configuration. Hyperibine J was found to be very similar to hyperforin and possesses a methyl substituent instead of a prenyl group at C‐1.
Copper‐Catalyzed Cross‐Coupling of Thiols, Alcohols, and Oxygen for the Synthesis of Esters
Authors: Lim Seungyeon , Ji Miran , Wang Xi , Lee Chan , Jang Hye‐Young 
Published: December 2014

AbstractCopper‐catalyzed, one‐pot, three‐component coupling reactions using thiols, alcohols, and oxygen to form a variety of esters in good yields were studied. In the presence of easily oxidized benzylic and allylic alcohols, thiols were selectively oxidized to form thionoesters, which underwent facile S/O exchange to afford esters. Thiols may be used as an alternative benzoyl source under mild aerobic conditions.
Convenient Chemoenzymatic Route to Optically Active β‐Aryl‐δ‐iodo‐γ‐lactones and β‐Aryl‐γ‐iodo‐δ‐lactones with the Defined Configurations of Stereogenic Centers
Authors: Gładkowski Witold , Skrobiszewski Andrzej , Mazur Marcelina , Siepka Monika , Białońska Agata 
Published: December 2014

AbstractTwo δ‐iodo‐γ‐lactones and two γ‐iodo‐δ‐lactones substituted at the β‐position with phenyl or 4‐methylphenyl ring have been synthesized in both enantiomeric forms. The starting materials were enantiomerically enriched allyl alcohols with an (E)‐4‐phenylbut‐3‐en‐2‐ol system (ee in the range 88–99 %), which were obtained by lipase‐catalyzed transesterification. Alcohols were subjected to orthoacetate modification of the Claisen rearrangement. The high stereoselectivity of this reaction led to retention of (E)‐configuration of the double bond and complete transfer of chirality from the allyl alcohol to the benzylic position C‐3. As a result, chiral γ,δ‐unsaturated esters with retained configuration of the stereogenic center were produced. Their hydrolysis and iodolactonization afforded new enantiomers of iodolactones with high or excellent ee (97–99 %). Their configuration at C‐4 was a direct result of the configuration at C‐3 of the acid subjected to iodolactonization, whereas stereocenters at C‐5 and C‐6 were formed as a consequence of the reaction mechanism. For most of the synthesized isomers, the predicted configurations were established by X‐ray analysis. The presented chemoenzymatic pathway represents a useful strategy that can be applied in the asymmetric synthesis of variety of lactones from 4‐arylbut‐3‐en‐2‐ols.
Ceci n'est pas la mort: Evidence for the recruitment of self‐reference from surrealistic art under mortality salience
Authors: Silveira Sarita , Gutyrchik Evgeny , Wetherell Geoffrey , Bao Yan , Pöppel Ernst , Blautzik Janusch , Reiser Maximilian , Frey Dieter , Graupmann Verena 
Published: December 2014

AbstractPrevious research has demonstrated that death reminders influence how we perceive art. In the context of terror management theory, this has been explained by the death‐transcending quality of art to convey cultural meaning. In two studies, we examined psychological and neurocognitive responses to naturalistic and surrealistic art when death was primed. We found that naturalistic paintings were evaluated similarly in terms of personal reassurance in both mortality salience and control condition, whereas surrealistic paintings were evaluated as more reassuring in the mortality salience condition than in the control condition. Using high‐field functional magnetic resonance imaging in a second study, we found a similar pattern of results, showing specific activation in the precuneus, a brain area associated with self‐related operations, in all prime conditions for the viewing of naturalistic paintings, but only in the death and disgust prime conditions when viewing surrealistic paintings. Our results suggest motivated self‐reference when viewing both naturalistic and surrealistic artworks under mortality salience. Copyright © 2014 John Wiley & Sons, Ltd.
PENTEL Actin‐G Immunoelectrode: Immunoassay at the Tip of a Pencil
Authors: Rathod Dhanraj , Warren Susan , Seddon Brian , Singh Baljit , Dempsey Eithne 
Published: December 2014

AbstractHere we present design and assay methodology of an actin‐G immunoelectrode for the quantitation of muscle protein, actin. The immunoelectrode was assembled using a proprietary pencil material composed of a polymer‐resin and graphite composite as an antibody support and electronic conductor. An effective immobilisation procedure for the capture antibody and surface blocking protein is cited based on a two‐step physisorption chemistry. BSA coverage was demonstrated to reduce non‐specific interactions to below 8 % of the base polymer‐graphite binding capacity. Immunoassays performed with the actin immunoelectrode utilise an o‐benzoquinone‐diimine electrochemistry which is formed in‐situ by interfacial peroxidase oxidation. Cyclic voltammetry data revealed the immunoelectrode surface to be porous to the diimine signalling molecule, while remaining inaccessible to macromolecules of the ELISA. The molecular structure and poly‐functional nature of the immunoelectrode was further investigated using an anti‐antibody peroxidase conjugate. The findings suggest that capture antibody is randomly dispersed over the surface, exposing both Fc and actin binding sites. A saturation current density – concentration curve was analysed by Langmuir adsorption theory and an estimate for the antibody binding affinity derived (Ka≈1×105 M−1). The actin immunoelectrode was applied as a peroxidase detector in a double‐antibody immunoassay. The electrode shows a dose‐response characteristic which is most sensitive to actin over the concentration range 1–100 ng mL−1. Immunoelectrode sensitivity for actin is of the order of 5 nA mm−2/ng mL−1 (10–100 ng mL−1) with a limit of detection estimated at 10 ng mL−1 and measurement precision RSD 7.1 % (100 ng mL−1 actin). At higher concentrations of actin, >100 ng mL−1 the immunoelectrode response is more complex. A high‐dose hook characteristic becomes evident which arises from macromolecular steric interactions and other binding site limitations at the electrode surface.
Analysis of composite steel and concrete columns at high temperatures
Authors: Jacintho Ana Elisabete P. G. A. , Silva Valdir P. , Requena João A. V. , Lintz Rosa C. C. , Gachet‐Barbosa Luisa A. , Pimentel Lia L. 
Published: December 2014

SummaryThe growing demand for knowledge about the effect of fire on structures has stimulated research worldwide. This article presents experimental results of short, composite columns made of steel and concrete when submitted to high temperatures in furnaces, with and without axial compression loading, as well as a numerical analysis of the temperature distribution in these columns. The columns were modeled as concrete‐filled tubes with three thicknesses and two diameters considered. In addition, standard fire temperature–time curves were obtained experimentally for use in the numerical calculations. Copyright © 2014 John Wiley & Sons, Ltd.
Taxonomy and distribution of the genus Quillaja Molina (Quillajaceae)
Authors: Luebert Federico 
Published: December 2014

AbstractThe taxonomy and distribution of the genus Quillaja (Quillajaceae) is examined and two species, Q. brasiliensis and Q. saponaria, are recognised and keyed out. Quillaja bra‐ siliensis is distributed in southern Brazil, northern Uruguay, northeastern Argentina and eastern Paraguay. The presence of Q. brasiliensis in Peru, indicated in some sources, is not confirmed with herbarium specimens. Quillaja saponaria is distributed in central Chile, besides one doubtful collection from Andean Bolivia. The mention of its presence in Peru is likewise unjustified. A distribution map of the species is provided and two names are lectotypified here.Se examina la taxonomía y distribución del género Quillaja (Quillajaceae), donde dos especies, Q. brasiliensis y Q. saponaria, se reconocen y diferencian mediante una clave. Quillaja brasiliensis se distribuye en el sur de Brasil, norte de Uruguay, noreste de Argentina y este de Paraguay. La presencia de Q. brasiliensis en Perú, indicada en algunas fuentes, no se ve respaldada por ejemplares de herbario. Quillaja saponaria se distrbuye en Chile central, más una colección dudosa proveniente de los Andes de Bolivia. La mención de Q. saponaria para Perú tampoco se justifica. Se presenta un mapa de distribución de las especies y se lectotipifican dos nombres. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hydration properties and texture fingerprints of easy‐ and hard‐to‐cook bean varieties
Authors: Kinyanjui Peter K. , Njoroge Daniel M. , Makokha Anselimo O. , Christiaens Stefanie , Ndaka Daniel S. , Hendrickx Marc 
Published: December 2014

AbstractThe objective of this study was to understand the factors that affect the hydration and cooking profiles of different bean varieties. During this study, nine bean varieties were classified as either easy‐to‐cook (ETC) or hard‐to‐cook (HTC) based on a subjective finger pressing test and an objective cutting test. Rose coco, Red haricot, and Zebra beans were classified as ETC, while Canadian wonder, Soya fupi, Pinto, non‐nodulating, Mwezi moja, Gwaku, and New mwezi moja were HTC. The effect of different soaking (pre)‐treatments on the cooking behavior and/or water absorption of whole or dehulled beans was investigated. Dehulling, soaking in high pH and monovalent salt solutions reduced the cooking time of beans, while soaking in low pH and CaCl2 solutions increased the cooking time. Moisture uptake was faster in ETC and dehulled beans. Soaking at high temperatures also increased the hydration rate. The results point to pectin‐related aspects and the rate of water uptake as possible factors that influence the cooking rate of beans.
Association of sialolithiasis with cholelithiasis: A population‐based study
Authors: Hung Shih‐Han , Lin Herng‐Ching , Su Chin‐Hui , Chung Shiu‐Dong 
Published: December 2014

AbstractBackgroundThe purpose of this study was to evaluate the association between cholelithiasis and developing sialolithiasis using a population‐based coverage database.MethodsThe data for this study were sourced from the Taiwan Longitudinal Health Insurance Database. We included 745 subjects with sialolithiasis as cases and 3725 sex‐matched and age‐matched subjects without sialolithiasis as controls.ResultsChi‐square test revealed a significant difference in the prevalence of prior cholelithiasis between the cases and controls (8.6% vs 4.1%; p < .001). Furthermore, conditional logistic regression analysis indicated that the odds ratio (OR) of prior cholelithiasis for the cases was 2.19 (95% confidence interval [CI] = 1.62–2.98) when compared with the controls after adjusting for monthly income, geographic location, urbanization level, and tobacco use disorder. The adjusted OR of prior cholelithiasis for cases was 2.20 (95% CI = 1.46–3.33) and 2.15 (95% CI = 1.38–3.42) than controls for men and women, respectively.ConclusionThis study demonstrates an association between sialolithiasis and cholelithiasis. © 2015 Wiley Periodicals, Inc. Head Neck 38: 560–563, 2016
Multimodal imaging analysis of an orthotopic head and neck cancer mouse model and application of anti‐CD137 tumor immune therapy
Authors: Vahle Anne‐Kristin , Hermann Sven , Schäfers Michael , Wildner Michael , Kerem Alexander , Öztürk Ender , Jure–Kunkel Maria , Franklin Cindy , Lang Stephan , Brandau Sven 
Published: December 2014

AbstractBackgroundRecent technical progress makes sophisticated noninvasive imaging methods available for murine models. For the first time, in this study, we applied fluorodeoxyglucose (FDG)‐positron emission tomography (PET)‐CT and FDG‐PET‐MRI to a murine orthotopic model of head and neck cancer immunotherapy.MethodsTumor growth of floor of the mouth tumors was evaluated by multimodal small‐animal imaging using FDG‐PET‐CT and FDG‐PET‐MRI. The immunotherapeutic effects of anti‐CD137 antibody therapy were examined on body weight, tumor growth, and tumor‐infiltrating immune cells in longitudinal imaging studies and immunohistochemical analyses.ResultsImaging revealed aggressive, fast‐growing tumors without evidence of local or distant metastases. CD137 immunotherapy decreased tumor take and growth and stabilized body weight over time. A clear case of tumor regression was demonstrated by longitudinal PET‐CT.ConclusionThe murine model mimics the characteristics of head and neck cancer in humans and offers excellent opportunities to investigate immunomodulatory anticancer drugs. The CD137 antibody showed antitumor effects in some therapy‐responsive mice. © 2015 Wiley Periodicals, Inc. Head Neck 38: 542–549, 2016
Readability and quality assessment of internet‐based patient education materials related to laryngeal cancer
Authors: Narwani Vishal , Nalamada Keerthana , Lee Michael , Kothari Prasad , Lakhani Raj 
Published: December 2014

AbstractBackgroundPatients are increasingly using the internet to access health‐related information. The purpose of this study was to assess the readability and quality of laryngeal cancer‐related websites.MethodsPatient education materials were identified by performing an internet search using 3 search engines. Readability was assessed using Flesch Reading Ease Score (FRES), Flesch–Kincaid Grade Level (FKGL), and Gunning Fog Index (GFI). The DISCERN instrument was utilized to assess quality of health information.ResultsA total of 54 websites were included in the analysis. The mean readability scores were as follows: FRES, 48.2 (95% confidence interval [CI] = 44.8–51.6); FKGL, 10.9 (95% CI = 10.3–11.5); and GFI, 13.8 (95% CI = 11.3–16.3). These scores suggest that, on average, online information about patients with laryngeal cancer is written at an advanced level. The mean DISCERN score was 49.8 (95% CI = 45.4–54.2), suggesting that online information is of variable quality.ConclusionOur study suggests much of the laryngeal cancer information available online is of suboptimal quality and written at a level too difficult for the average adult to read comfortably. © 2015 Wiley Periodicals, Inc. Head Neck 38: 601–605, 2016
PTH(1-34) Treatment Increases Bisphosphonate Turnover in Fracture Repair in Rats
Authors: Murphy Ciara M , Schindeler Aaron , Cantrill Laurence C , Mikulec Kathy , Peacock Lauren , Little David G 
Published: December 2014

Abstract

Bisphosphonates (BP) are antiresorptive drugs with a high affinity for bone. Despite the therapeutic success in treating osteoporosis and metabolic bone diseases, chronic BP usage has been associated with reduced repair of microdamage and atypical femoral fracture (AFF). The latter has a poor prognosis, and although anabolic interventions such as teriparatide (PTH(1–34)) have been suggested as treatment options, there is a limited evidence base in support of their efficacy. Because PTH(1–34) acts to increase bone turnover, we hypothesized that it may be able to increase BP in turnover in the skeleton, which, in turn, may improve bone healing. To test this, we employed a mixture of fluorescent Alexa647-labelled pamidronate (Pam) and radiolabeled 14C-ZA (zoledronic acid). These traceable BPs were dosed to Wistar rats in models of normal growth and closed fracture repair. Rats were cotreated with saline or 25 μg/kg/d PTH(1–34), and the effects on BP liberation and bone healing were examined by X-ray, micro-CT, autoradiography, and fluorescent confocal microscopy. Consistent with increased BP remobilization with PTH(1–34), there was a significant decrease in fluorescence in both the long bones and in the fracture callus in treated animals compared with controls. This was further confirmed by autoradiography for 14C-ZA. In this model of acute BP treatment, callus bone volume (BV) was significantly increased in fractured limbs, and although we noted significant decreases in callus-bound BP with PTH(1–34), these were not sufficient to alter this BV. However, increased intracellular BP was noted in resorbing osteoclasts, confirming that, in principle, PTH(1–34) increases bone turnover as well as BP turnover. © 2015 American Society for Bone and Mineral Research.
Osteoblast-Specific Expression of the Fibrous Dysplasia (FD)–Causing Mutation GsαR201C Produces a High Bone Mass Phenotype but Does Not Reproduce FD in the Mouse
Authors: Remoli Cristina , Michienzi Stefano , Sacchetti Benedetto , Consiglio Alberto Di , Cersosimo Stefania , Spica Emanuela , Robey Pamela G , Holmbeck Kenn , Cumano Ana , Boyde Alan , Davis Graham , Saggio Isabella , Riminucci Mara , Bianco Paolo 
Published: December 2014

ABSTRACT

We recently reported the generation and initial characterization of the first direct model of human fibrous dysplasia (FD; OMIM #174800), obtained through the constitutive systemic expression of one of the disease-causing mutations, GsαR201C, in the mouse. To define the specific pathogenetic role(s) of individual cell types within the stromal/osteogenic system in FD, we generated mice expressing GsαR201C selectively in mature osteoblasts using the 2.3kb Col1a1 promoter. We show here that this results in a striking high bone mass phenotype but not in a mimicry of human FD. The high bone mass phenotype involves specifically a deforming excess of cortical bone and prolonged and ectopic cortical bone remodeling. Expression of genes characteristic of late stages of bone cell differentiation/maturation is profoundly altered as a result of expression of GsαR201C in osteoblasts, and expression of the Wnt inhibitor Sost is reduced. Although high bone mass is, in fact, a feature of some types/stages of FD lesions in humans, it is marrow fibrosis, localized loss of adipocytes and hematopoietic tissue, osteomalacia, and osteolytic changes that together represent the characteristic pathological profile of FD, as well as the sources of specific morbidity. None of these features are reproduced in mice with osteoblast-specific expression of GsαR201C. We further show that hematopoietic progenitor/stem cells, as well as more mature cell compartments, and adipocyte development are normal in these mice. These data demonstrate that effects of Gsα mutations underpinning FD-defining tissue changes and morbidity do not reflect the effects of the mutations on osteoblasts proper. © 2015 American Society for Bone and Mineral Research. © 2014 American Society for Bone and Mineral Research
Surface Plasmon Resonance‐based Inhibitive Immunoassay Coupled with Dummy Template Molecularly Imprinted Polymer Solid Phase Extraction for On‐line Analysis of Trace Clenbuterol
Authors: Tang Pingping , Huo Jichuan , Zhang Hongping , Lei Hong , Lin Xiaoyan 
Published: December 2014

AbstractA new indirect inhibitive immunoassay using surface plasmon resonance (SPR) coupled with molecularly imprinted polymer (MIP) was developed and applied for the analysis of trace clenbuterol (CL). A MIP coating using phenylephrine as the dummy template was synthesized in a flexible quartz capillary (30 cm×0.25 mm i.d.) by in situ polymerization technique, which then was used as the online solid phase extraction (SPE) tube before SPR detection. The thickness of the coating was 198 nm on average, illustrated by scanning electron microscope (SEM) image. The mechanism for adsorption of CL on dummy template MIP was found to be a Freundlich isotherm and pseudo‐second‐order model. The immunoassay was conducted on BIAcore 3000 biosensor automatically without pre‐treatment. The calibration curve was generated by linear fit in the range of 0.1–10 ng L‐1 and 10–100 ng L‐1. The detection limit was 0.1 ng L–1, which is super sensitive. This method was directly applied for the analysis of real‐world samples without pretreatment.