bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of miR‐126‐3p and its Target Talin2 in the Bovine Corpus Luteum during the Oestrus Cycle
Authors: Dai L , Xu J , Liu S , Ma T , Zhu Y , Xu F , Gao Y , Yuan B , Wang S , Zhang Y , Sun G , Zhang J 
Published: September 2014

ContentsAlthough clear advances have been made in understanding of gene transcriptional regulation in the corpous luteum (CL) during the oestrous cycle, little is known about the involvement of microRNAs (miRNAs) in this physiological process. In the present study, expression of miR‐126‐3p was preliminarily detected in bovine CL throughout the oestrous cycle, while the expression during the middle or late stages was significantly more abundant (p < 0.01) than that during the early or regressed stages. Localization of miR‐126‐3p was subsequently observed in large and small luteal cells during the oestrous cycle in cattle. Meanwhile, to further investigate the function of miR‐126‐3p, its potential targets and responsive elements were determined and evaluated. It was revealed that miR‐126‐3p could target talin2 (TLN2) directly by binding the responsive element within the 3′‐UTR. Quantitative analysis of TLN2 at mRNA and protein level also suggested that there was an inverse correlation between miR‐126‐3p and TLN2 at the developmental luteal stages in cattle. Collectively, these results demonstrated that difference in the expression pattern and location of miR‐126‐3p occurred at different stages of the bovine CL and that miR‐126‐3p acted as an important regulator of TLN2, suggesting their putative involvement in the development of bovine CL during the oestrous cycle.
Tectonically driven deposition and landscape evolution within upland incised valleys: Ambra Valley fill, Pliocene–Pleistocene, Tuscany, Italy
Authors: Bianchi Valeria , Ghinassi Massimiliano , Aldinucci Mauro , Boaga Jacopo , Brogi Andrea , Deiana Rita 
Published: September 2014

AbstractSedimentation in the upstream reaches of incised valleys is predominantly of alluvial origin and, in most cases, independent from relative sea‐level or lake‐level oscillations. Preserved facies distributions record the depositional response to a combination of allogenic factors, including tectonics, climate and landscape evolution. Tectonics drive fluvial aggradation and degradation through local changes in gradient, both longitudinal and transverse to the valley slope. This article deals with a Pliocene–Pleistocene fluvial valley fill developed in the north‐eastern shoulder of the Siena Basin (Northern Apennines, Italy). Evolution of the valley was not influenced by sea‐level or lake‐level changes and morphological and depositional evolution of valley resulted from extensional tectonics that gave rise to normal and oblique‐slip faults orthogonal and parallel to the valley axis. Data from both field observations and geophysical study are interpreted to develop a comprehensive tectono‐sedimentary model of coeval longitudinal and lateral tilting of the developing alluvial plain. Longitudinal tilting was generated by a transverse, upstream‐dipping normal fault that controlled the aggradation of fining‐upward strata sets. Upstream of the fault zone, valley back‐filling generated an architecture similar to that of classic, sea‐level‐controlled, coastal incised valleys. Downstream of the fault zone, valley down‐filling was related to an overwhelming sediment supply sourced and routed from the active fault zone itself. Lateral tilting was promoted by the activity of a fault oriented parallel to the valley axis, as well as by different offsets along near orthogonal faults. As a result, the valley trunk system experienced complex lateral shifts, which were governed by interacting fault‐generated subsidence and by the topographic confinement of progradational, flank‐sourced alluvial fans.
What Type of Resources? Household Effects and Female Electoral Participation
Authors: Stadelmann‐Steffen Isabelle , Koller Daniela 
Published: September 2014

AbstractThis paper investigates the relationship between socioeconomic resources and women's political participation, more precisely whether the distinction between individual and household resources helps to identify different mechanisms behind a possible “resource effect”. Based on a Bayesian multilevel analysis using the Swiss Election Study 2011, we show that both individual and household resources matter for explaining female electoral participation. However, resource effects must not necessarily be positive: While higher education of women and their partners tend to increase female participation, a demanding job of either the woman and/or her partner rather decreases her propensity to vote. Moreover, the mechanisms behind partner effects are contingent on women's individual resource endowment. While low and medium educated women most strongly profit from higher educational partner resources, i.e. from a compensatory mechanism, the resource “time” seems to particularly confine political involvement of women with both high professional status or no employment.
Unrelated donor HLA re‐typing effort to verify prevalence of newer alleles: HLA‐A*24:23, A*30:10, DRB1*08:11, DRB1*15:03, and DRB1*15:06
Authors: Kempenich J. , Dehn J. , Flickinger G. , Setterholm M. 
Published: September 2014

AbstractThe National Marrow Donor Program (NMDP) is committed to maintaining accurate human leukocyte antigen (HLA) data for each of the 11.5 million volunteer donors on the Be The Match Registry®. Qualitative data analysis identified five population specific alleles suspect of being incorrectly characterized. Alleles evaluated were HLA‐A*24:03 for the presence of A*24:23 in Native Americans, A*30:02 for the presence of A*30:10 when B*41 and DRB1*04:05 were in the haplotype, DRB1*08:02 for the presence of DRB1*08:11 in Native Americans, and DRB1*15:01 for the presence of DRB1*15:03 in African Americans or DRB1*15:06 in Asian donors. Discrepancy rate was 55%, 86%, 31%, 75%, and 13%, respectively. Utilizing the HLA typing date, race, and date an allele in question was described may provide a selection strategy leading to the consideration of additional unrelated donors for searching patients.
Infant twin mortality and hospitalisations after the perinatal period – a prospective cohort study from Guinea‐Bissau
Authors: Bjerregaard‐Andersen M. , Biering‐Sørensen S. , Gomes G. M. , Bidonga A. , Jensen D. M. , Rodrigues A. , Christensen K. , Aaby P. , Beck‐Nielsen H. , Benn C. S. , Sodemann M. 
Published: September 2014

AbstractObjectiveTo examine mortality and hospitalisations among infant twins and singletons after the perinatal period in Guinea‐Bissau.MethodsThe study was conducted from September 2009 to November 2012 by the Bandim Health Project (BHP). Newborn twins and unmatched singleton controls were included at the National Hospital Simão Mendes in the capital Bissau. Children were examined clinically at enrolment. Maternal, pregnancy and obstetric information was collected and HIV testing offered at birth. Follow‐up occurred at home at 2, 6 and 12 months and through linkage with the paediatric admission register at the National Hospital.ResultsAbout 495 twins and 333 singletons were alive on day 7 after birth. In total, 36 twins and 12 singletons died during follow‐up, the post‐perinatal infant mortality rate being 91/1000 person‐years for twins and 42/1000 for singletons (HR = 2.11, 95% CI: 1.09–4.07). In a multivariable analysis among twins only, birth weight <2000 g [3.32, (1.36–8.07)], death of the cotwin perinatally [2.54, (1.16–5.57)] and severe maternal illness during pregnancy [2.35, (1.00–5.51)] were significant risk factors for twin death. In the subgroup with available HIV status, maternal HIV infection was strongly associated with twin mortality [3.16, (1.24–8.05)]. Death occurred at home for 60% of twins and 67% of singletons. During follow‐up, 90 first‐time hospital admissions were registered, with similar rates observed for twins (139/1000) and singletons (143/1000) [0.97, (0.61–1.52)].ConclusionThe post‐perinatal infant mortality rate of twins was double that of singletons. No excess in twin hospitalisations was observed, possibly implying obstacles to hospital admission for twins in case of severe illness.
Human Rabies Post‐Exposure Prophylaxis and Animal Rabies in Ontario, Canada, 2001–2012
Authors: Middleton D. , Johnson K. O. , Rosatte R. C. , Hobbs J. L. , Moore S. R. , Rosella L. , Crowcroft N. S. 
Published: September 2014

SummaryIn Ontario, Canada, the implementation of an annual rabies control programme in wildlife that began in 1989 resulted in a marked, steady decrease in the number of animal rabies cases. The number of animal rabies cases decreased from 1870 in 1989 to 183 in 2000 (Nunan et al., 2002 Emerg Infect Dis 8, 214). In our study period, the number of animal rabies cases continued to decrease from 210 in 2001 to 28 in 2012. The marked decrease in animal rabies cases since 1989 has resulted in a decrease in the risk of human infection. A concomitant decrease in the number of rabies post‐exposure prophylaxis (RPEP) administered was anticipated but failed to occur. The mean rate of RPEP, 13.9 RPEP administered per 100 000 persons, from 2001–2012 was approximately the same as the rate in the 1990s. Two possible reasons that the rate of RPEP administration has not decreased include strict adherence to RPEP recommendations and administration of RPEP when it is not recommended. A reduction in the number of RPEP administered, consistent with the decrease in the animal rabies cases, would provide some financial savings for the government. Ideally, an increased use of the risk assessment approach in keeping with recent guidelines, rather than adhering to previous prescriptive recommendations for RPEP administration, coupled with a continuing low incidence of animal rabies cases will result in decreased, and yet appropriate, use of RPEP. Consideration should be given to identify how guidelines could be revised to more effectively target high‐risk exposures and reduce the administration of RPEP for instances in which the risk of rabies virus exposure is exceedingly low.
Tick Bite Prophylaxis: Results From a 2012 Survey of Healthcare Providers
Authors: Perea A. E. , Hinckley A. F. , Mead P. S. 
Published: September 2014

SummaryIn a recent national survey, over 30% of healthcare providers (HCPs) reported prescribing tick bite prophylaxis in the previous year. To clarify provider practices, we surveyed HCPs to determine how frequently and for what reasons they prescribed tick bite prophylaxis. We included four questions regarding tick bite prophylaxis in the DocStyles 2012 survey, a computer‐administered questionnaire of 2205 US primary care physicians, paediatricians and nurse practitioners. Responses in 14 states with high Lyme disease incidence (high LDI) were compared with responses from other states (low LDI). Overall, 56.4% of 1485 providers reported prescribing tick bite prophylaxis at least once in the previous year, including 73.9% of HCPs in high LDI and 48.2% in low LDI states. The reasons given were ‘to prevent Lyme disease’ (76.9%), ‘patients request it’ (40.4%) and ‘to prevent other tickborne diseases’ (29.4%). Among HCPs who provided prophylaxis, 45.2% did so despite feeling that it was not indicated. Given a hypothetical scenario involving a patient with an attached tick, 38.1% of HCPs from high LDI states and 15.1% from low LDI states would prescribe a single dose of doxycycline; 19.0% from high LDI states and 27.5% from low LDI states would prescribe a full course of doxycycline. HCPs prescribe tick bite prophylaxis frequently in areas where Lyme disease is rare and for tickborne diseases for which it has not been shown effective. HCPs may be unaware of current tick bite prophylaxis guidelines or find them difficult to implement. More information is needed regarding the efficacy of tick bite prophylaxis for diseases other than Lyme disease.
Dogs Entering the United States from Rabies‐Endemic Countries, 2011–2012
Authors: Sinclair J. R. , Washburn F. , Fox S. , Lankau E. W. 
Published: September 2014

SummaryInternational dog imports pose a risk because of the potential movement of disease agents, including the canine rabies virus variant which has been eliminated from the United States since 2007. US regulations require a rabies vaccination certificate for dogs arriving from rabies‐endemic countries, but permit the importation of dogs that have not been adequately immunized against rabies, provided that the dogs are confined under conditions that restrict their contact with humans and other animals until they have been immunized. CDC Form 75.37, ‘Notice to Owners and Importers of Dogs’, explains the confinement requirements and serves as a binding confinement agreement with the importer. In this evaluation, we describe the characteristics of unimmunized dogs imported into the United States over a 1‐year period based upon dog confinement agreements recorded at the Centers for Disease Control and Prevention (CDC) quarantine stations. Confinement agreements were issued for nearly 2800 unimmunized dogs that entered the United States during 1 June 2011–31 May 2012, the majority of which travelled to the United States by air and without any seasonal pattern in import volume. Over 60% of these animals were puppies <3 months of age and included a wide variety of breeds. The dogs arrived from 81 countries, with the majority arriving from North America or Europe. Dogs placed on confinement agreements had final destinations in 49 states. California, New York, Texas, Washington and Florida received the largest number of dogs on confinement agreements. These results (which do not reflect human travel or US dog ownership data) suggest that a large portion of unimmunized dogs arrive from rabies‐endemic countries for commercial, shelter and rescue purposes. Further evaluation and key stakeholder involvement are needed to assess whether the current dog importation regulations are an adequate compromise between the benefits and risks of dog importation.
Retention of Black and White Participants in the Selenium and Vitamin E Cancer Prevention Trial (SWOG-Coordinated Intergroup Study S0000)
Authors: Arnold Kathryn B. , Hermos John A. , Anderson Karen B. , Minasian Lori , Tangen Catherine M. , Probstfield Jeffrey F. , Cook Elise D. 
Published: September 2014

Abstract
Background: Disproportionally low retention of minority populations can adversely affect the generalizability of clinical research trials. We determine the overall retention rates for White and Black participants from the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and explore participant and site characteristics associated with retention failure (study disengagement) for these groups.
Methods: A secondary analysis of 28,118 White (age ≥55), and 4,322 Black (age ≥ 50) SELECT participants used multivariate Cox regression to estimate overall retention rates and to calculate HRs and 95% confidence intervals (CI).
Results: Blacks had higher age-adjusted risk of disengagement than Whites (HR, 1.92; 95% CI, 1.77–2.08). Among Black participants, those ages 50 to 54 were at three times the risk of disengagement than those ≥65 years of age (HR, 3.61; 95% CI, 2.41–5.41). Blacks age ≥65 had 1.6 times the risk of disengagement than Whites age ≥65 (HR, 1.60; 95% CI, 1.38–1.87). By 6 years after randomization, 84% of Whites and 69% of Blacks remained engaged in the study. Current smoking status was an independent risk factor for study disengagement for both White and Black participants. For both groups, sites whose staffs missed SELECT training sessions or who received SELECT Retention and Adherence grants were associated with increased and decreased disengagement risks, respectively.
Conclusions: SELECT retention was disproportionately lower for Blacks than for Whites.
Impact: The observed difference in retention rates for Blacks and Whites and factors identified by race for study disengagement in SELECT may inform retention efforts for future long-term, cancer prevention trials. Cancer Epidemiol Biomarkers Prev; 23(12); 2895–905. ©2014 AACR.
Driving Blind: Weather-Related Vision Hazards and Fatal Motor Vehicle Crashes
Authors: Ashley Walker S. , Strader Stephen , Dziubla Douglas C. , Haberlie Alex 
Published: September 2014

AbstractVisibility-related weather hazards have significant impacts on motor vehicle operators because of decreased driver vision, reduced roadway speed, amplified speed variability, and elevated crash risk. This research presents a national analysis of fog-, smoke-, and dust storm–associated vehicular fatalities in the United States. Initially, a database of weather-related motor vehicle crash fatalities from 1994 to 2011 is constructed from National Highway Traffic Safety Administration data. Thereafter, spatiotemporal analyses of visibility-related (crashes where a vision hazard was reported at time of event) and vision-obscured (driver’s vision was recorded as obscured by weather, and a weather-related vision hazard was reported) fatal vehicular crashes are presented. Results reveal that the annual number of fatalities associated with weather-related, vision-obscured vehicular crashes is comparable to those of more notable and captivating hazards such as tornadoes, floods, tropical cyclones, and lightning. The majority of these vision-obscured crash fatalities occurred in fog, on state and U.S. numbered highways, during the cool season and during the morning commuting hours of 0500 to 0800 local time. Areas that experience the greatest frequencies of vision-obscured fatal crashes are located in the Central Valley of California, Appalachian Mountain and mid-Atlantic region, the Midwest, and along the Gulf Coast. From 2007 to 2011, 72% of all vision-obscured fatal crashes occurred when there was no National Weather Service weather-related visibility advisory in effect. The deadliest weather-related visibility hazard crashes during the period are exhibited, revealing a spectrum of environmental and geographical settings that can trigger these high-end events.
Roles of the Synoptic-Scale Wave Train, the Intraseasonal Oscillation, and High-Frequency Eddies in the Genesis of Typhoon Manyi (2001)*
Authors: Xu Yamei , Li Tim , Peng Melinda 
Published: September 2014

Abstract
Experiments using the Weather Research and Forecasting (WRF) Model were conducted to investigate the effects of multiscale motions on the genesis of Typhoon Manyi (2001) in the western North Pacific. The precursor signal associated with this typhoon genesis was identified as a northwest–southeast-oriented synoptic-scale wave train (SWT). The model successfully simulated the genesis of the typhoon in the wake of the SWT. Further experiments were conducted to isolate the effects of the SWT, the intraseasonal oscillation (ISO), and high-frequency (shorter than 3 days) eddies in the typhoon formation.
Removing the SWT in the initial and boundary conditions eliminates the typhoon genesis. This points out the importance of the SWT in the typhoon genesis. It was noted that the SWT strengthened the wake cyclone through southeastward energy dispersion. The strengthening wake cyclone triggered multiple episodes of strong sustained convective updrafts, leading to aggregation of vertical vorticity and formation of a self-amplified mesoscale core vortex through a “bottom up” development process. Removing the ISO flow eliminates the typhoon genesis, as the ISO significantly modulated the strength of the SWT through accumulation of wave activity. In the absence of SWT–ISO-scale interaction, the southeastward energy dispersion was weakened significantly, and thus the strengthening of the wake cyclone did not occur. As a result, the successive strong sustained convective updrafts disappeared. Removing the high-frequency eddies did not eliminate the typhoon genesis but postponed the genesis for about 36 h.
The Red Sea: A Natural Laboratory for Wind and Wave Modeling
Authors: Langodan Sabique , Cavaleri Luigi , Viswanadhapalli Yesubabu , Hoteit Ibrahim 
Published: September 2014

Abstract
The Red Sea is a narrow, elongated basin that is more than 2000 km long. This deceivingly simple structure offers very interesting challenges for wind and wave modeling, not easily, if ever, found elsewhere. Using standard meteorological products and local wind and wave models, this study explores how well the general and unusual wind and wave patterns of the Red Sea could be reproduced. The authors obtain the best results using two rather opposite approaches: the high-resolution Weather Research Forecasting (WRF) local model and the slightly enhanced surface winds from the global European Centre for Medium-Range Weather Forecasts model. The reasons why these two approaches produce the best results and the implications on wave modeling in the Red Sea are discussed. The unusual wind and wave patterns in the Red Sea suggest that the currently available wave model source functions may not properly represent the evolution of local fields. However, within limits, the WAVEWATCH III wave model, based on Janssen’s and also Ardhuin’s wave model physics, provides very reasonable results in many cases. The authors also discuss these findings and outline related future work.
Analysis of Strengthening and Dissipating Mesoscale Convective Systems Propagating off the West African Coast
Authors: Dieng Abdou L. , Eymard Laurence , Sall Saidou M. , Lazar Alban , Leduc-Leballeur Marion 
Published: September 2014

Abstract
A large number of Atlantic tropical depressions are generated in the eastern basin in relation to the African easterly wave (AEW) and embedded mesoscale convective systems (MCSs) coming from the African continent. In this paper, the structures of strengthening and dissipating MCSs evolving near the West African coast are analyzed, including the role of the ocean surface conditions in their evolution.
Satellite infrared brightness temperature and meteorological radar data over seven summer seasons between 1993 and 2006 are used to subjectively select 20 cases of strengthening and dissipating MCSs in the vicinity of the Senegal coast. With these observed MCSs, a lagged composite analysis is then performed using Interim ECMWF Re-Analysis (ERA-Interim) and Climate Forecast System Reanalysis (CFSR).
It is shown that the strengthening MCS is generally preceded by prior passage of an AEW near the West African coast. This previous wave trough is associated with a convective cyclonic circulation in the low and middle troposphere, which enhances the southwesterly flow and then provides humidity to the strengthening MCS, located in the vicinity of the subsequent AEW trough. This is favored by the contraction of the wavelength associated with the two troughs. The sea surface contributes to the MCS enhancement through surface evaporation flux. But this contribution is found to be less important than advection of humidity from the previous wave trough. These conditions are almost not found in the dissipating MCS cases, which dissipate in a dry environment dominated by a subsident and anticyclonic circulation, with generally no interaction with a previous wave trough.
Primary Ewing sarcoma/primitive neuroectodermal tumor of the renal pelvis: a case report
Authors: Liu Zhihong , Wang Xianding , Lu You , Chen Libo , Lu Yiping 
Published: September 2014

Abstract
Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a childhood malignancy, typically occurring in the bone and rarely in any other part of the body. We herein present a case of ES/PNET of the renal pelvis. A 37-year-old male patient presented with a chief complaint of pain in the left flank and gross hematuria. The tumor had caused moderate hydronephrosis, and ureteroscopic biopsy findings were highly suspicious of sarcoma. Subsequently, radical nephroureterectomy was performed. On the basis of the pathological and cytogenetic findings, a final diagnosis of primary ES/PNET of left renal pelvis was made. Adjuvant chemotherapy with adriamycin and ifosfamide was initiated as ES/PNET often exhibits aggressive biological behavior. The patient was disease-free at his last regular follow-up visit 18 months after the surgery. To our knowledge, this is the first reported case of primary ES/PNET of the renal pelvis.