bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpersonal Factors Are Associated with Lower Therapist Adherence in Cognitive–Behavioural Therapy for Panic Disorder
Authors: Zickgraf Hana F. , Chambless Dianne L. , McCarthy Kevin S. , Gallop Robert , Sharpless Brian A. , Milrod Barbara L. , Barber Jacques P. 
Published: April 2015

ObjectiveThe contributions of disorder severity, comorbidity and interpersonal variables to therapists' adherence to a cognitive–behavioural treatment (CBT) manual were tested.MethodThirty‐eight patients received panic control therapy (PCT) for panic disorder. Trained observers watching videotapes of the sixth session of a 24‐session protocol rated therapists' adherence to PCT and their use of interventions from outside the CBT model. Different observers rated patients' behavioural resistance to therapy in the same session using the client resistance code. Interview measures obtained before treatment included the Panic Disorder Severity Scale, the anxiety disorders interview schedule for Diagnostic and Statistical Manual of Mental Disorders (DSM)‐IV and the structured clinical interview for DSM‐IV, Axis II. Questionnaire measures were the anxiety sensitivity index at intake, and, at session 2, the therapist and client versions of the working alliance inventory—short form.ResultsThe higher the patients' resistance and the more Axis II traits a patient had, the less adherent the therapist. Moreover, the more resistant the client, the more therapists resorted to interventions from outside the CBT model. Stronger therapist and patient alliance was also generally related to better adherence, but these results were somewhat inconsistent across therapists. Pretreatment disorder severity and comorbidity were not related to adherence.ConclusionsInterpersonal variables, particularly behavioural resistance to therapy, are related to therapists' ability to adhere to a treatment manual and to their use of interventions from outside of the CBT model. Copyright © 2015 John Wiley & Sons, Ltd.Key Practitioner message

Patients' behavioural resistance to therapy may make it more difficult for cognitive–behavioural clinicians to adhere to a structured treatment protocol and more likely for them to borrow interventions from outside the CBT model.
Patients' Axis II traits may make adherence to treatment CBT protocol more difficult, although whether this is true varies across therapists.
Therapists' adherence to a structured protocol and borrowing from outside of the CBT model do not appear to be affected by disorder severity or Axis I comorbidity.
Selective Hydrogenation of Furfural to Furfuryl Alcohol in the Presence of a Recyclable Cobalt/SBA‐15 Catalyst
Authors: Audemar Maïté , Ciotonea Carmen , De Oliveira Vigier Karine , Royer Sébastien , Ungureanu Adrian , Dragoi Brindusa , Dumitriu Emil , Jérôme François 
Published: April 2015

AbstractThe hydrogenation of furfural to furfuryl alcohol was performed in the presence of a Co/SBA‐15 catalyst. High selectivity (96 %) at a conversion higher than 95 % is reported over this catalytic system. As the conversion of furfural to furfuryl alcohol occurs over metallic Co sites, the effect of reduction temperature, H2 pressure, and reaction temperature were studied. Optimum reaction conditions were: 150 °C, 1.5 h, 2.0 MPa of H2. The catalyst was recyclable, and furfuryl alcohol was recovered with a purity higher than 90 %. The effect of the solvent concentration was also studied. With a minimum of 50 wt % of solvent, the selectivity to furfuryl alcohol and the conversion of furfural remained high (both over 80 %). Likewise, the activity of the catalyst is maintained even in pure furfural, which confirms the real potential of the proposed catalytic system. This catalyst was also used in the hydrogenation of levulinic acid to produce γ‐valerolactone selectively.
Highly Selective Condensation of Biomass‐Derived Methyl Ketones as a Source of Aviation Fuel
Authors: Sacia Eric R. , Balakrishnan Madhesan , Deaner Matthew H. , Goulas Konstantinos A. , Toste F. Dean , Bell Alexis T. 
Published: April 2015

AbstractAviation fuel (i.e., jet fuel) requires a mixture of C9–C16 hydrocarbons having both a high energy density and a low freezing point. While jet fuel is currently produced from petroleum, increasing concern with the release of CO2 into the atmosphere from the combustion of petroleum‐based fuels has led to policy changes mandating the inclusion of biomass‐based fuels into the fuel pool. Here we report a novel way to produce a mixture of branched cyclohexane derivatives in very high yield (>94 %) that match or exceed many required properties of jet fuel. As starting materials, we use a mixture of n‐alkyl methyl ketones and their derivatives obtained from biomass. These synthons are condensed into trimers via base‐catalyzed aldol condensation and Michael addition. Hydrodeoxygenation of these products yields mixtures of C12–C21 branched, cyclic alkanes. Using models for predicting the carbon number distribution obtained from a mixture of n‐alkyl methyl ketones and for predicting the boiling point distribution of the final mixture of cyclic alkanes, we show that it is possible to define the mixture of synthons that will closely reproduce the distillation curve of traditional jet fuel.
Mechanism of Brønsted Acid‐Catalyzed Glucose Dehydration
Authors: Yang Liu , Tsilomelekis George , Caratzoulas Stavros , Vlachos Dionisios G. 
Published: April 2015

AbstractInvited for this month′s cover is the group of Dionisios Vlachos and Stavros Caratzoulas at the University of Delaware. The image shows how a multidisciplinary approach can be utilized to solve complex problem in biomass conversion. The Full Paper itself is available at 10.1002/cssc.201403264.
Measuring murine chromosome orientation in interphase nuclei
Authors: Righolt Christiaan H. , Schmälter Ann‐Kristin , Kuzyk Alexandra , Young Ian T. , van Vliet Lucas J. , Mai Sabine 
Published: April 2015

AbstractThe nuclear architecture of a cell may change as a result of various diseases, including cancer. A variety of nuclear features are, therefore, of interest to cell biologists. Recently, several studies have investigated the orientation of chromosomes in the interphase nucleus either visually or semi‐automatically. In this article an automated method to measure this orientation is presented. The theoretical difference between performing these measurements in two and three dimensions is discussed and experimentally verified. The results computed from measurements of murine nuclei correspond with results from visual inspection. We found significant differences in the orientation of chromosome 11 between nuclei from a PreB cell line of BALB/c origin and primary B nuclei from congenic [T38HxBALB/c]N wild‐type mice. Since our new automatic method concurs with both the visual and semi‐automatic methods, we conclude that the automatic method can replace these methods in assessing chromosome orientation. © 2015 International Society for Advancement of Cytometry
Experimental‐numerical research on the seismic performance of URM buildings made of lightweight AAC blocks / Experimentell‐numerische Untersuchung zum seismischen Verhalten von unbewehrten Mauerwerksgebäuden aus Porenbetonblöcken
Authors: Penna Andra , Magenes Guido , Rota Maria , Mandirola Martina , Rosti Annalisa 
Published: April 2015

AbstractMasonry walls constructed with lightweight AAC blocks and thin‐layer mortar meet the increasingly strict requirements of energy efficiency and sustainability. In this sense, they represent an excellent solution for modern buildings, not only for external cladding but also as loadbearing elements. Despite the possible advantages of using lightweight AAC masonry, a specific assessment of its seismic performance is mandatory in order to set design recommendations allowing to reach safety levels consistent with those required for other masonry types complying with EN 1998 standard requirements.A comprehensive study on the seismic performance of unreinforced masonry buildings made of lightweight AAC was carried out in an integrated experimental‐numerical approach. The experimental campaign provided the necessary information to setup a reliable numerical model to be extensively used to assess the seismic performance of a number of prototype AAC masonry buildings with different characteristics, by means of both linear and nonlinear static (pushover) analysis.The results of this systematic numerical assessment were eventually used to draft design recommendations, to set parameters (behaviour factors) to be used in linear analysis and to calibrate rules for simple buildings.
Generation and characterization of PDGFRα‐GFPCreERt2 knock‐In mouse line
Authors: Miwa Hiroyuki , Era Takumi 
Published: April 2015

SummaryPlatelet‐derived growth factor (PDGF) and its receptor play an important role in embryogenesis. PDGF receptor α (PDGFRα) is expressed specifically in the embryonic day 7.5 (E7.5) mesoderm and in the E9.5 neural crest among other tissues. PDGFRα‐expressing cells and their descendants are involved in the formation of various tissues. To trace PDGFRα‐expressing cells in vivo, we generated a knock‐in mouse line that expressed a fusion protein of green fluorescent protein (GFP), Cre recombinase (Cre), and mutated estrogen receptor ligand‐binding domain (ERT2) under the control of the PDGFRα promoter. In these mice, Cre activity in PDGFRα‐expressing cells could be induced by tamoxifen treatment. Taken together, our results suggest that the knock‐in mouse line generated here could be useful for studying PDGFRα‐expressing cells and their descendants in vivo at various stages of development. genesis 53:329–336, 2015. © 2015 Wiley Periodicals, Inc.
Model Forests in the Russian Federation: Local Perspectives, Challenges and Outcomes
Authors: Ulybina Olga 
Published: April 2015

AbstractWe discuss the development, challenges and outcomes of model forests in the Russian Federation as potential tools to help ensure forest‐based sustainable development. We use in‐depth interviews to explore local perspectives on Pskov and Gassinski model forests. We find that despite demand for change from some local non‐governmental and companies, as well as support from international players, the idea of participatory environmental governance is still not widely accepted, the system remains dominated by the traditionally big state and effects of such alternative initiatives remain limited. Using our case studies, we show that unless domestic and international stakeholders of model forests refocus their efforts, model forests are likely to remain unstable ‘islands’ of change with only limited local impact. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Terpenyl Selenides: Synthesis and Application in Asymmetric Epoxidation
Authors: Banach Anna , Ścianowski Jacek , Uzarewicz‐Baig Magdalena , Wojtczak Andrzej 
Published: April 2015

AbstractSynthesis of terpenyl selenides derived from limonene, menthol, caranol, and myrtanol is described. Three methodologies for the synthesis of terpenyl selenonium salts are compared. The results of selenium‐mediated epoxidation through the use of isoselenocineole derived from limonene and methyl terpenyl, phenyl terpenyl, diterpenyl selenides, and selenonium salts are presented. The influence of solvent, counteranion, and diastereomeric purity of selenonium salt on the enantioselectivity of the epoxidation reaction is discussed.
Phospholane‐Catalyzed Wittig Reaction
Authors: Werner Thomas , Hoffmann Marcel , Deshmukh Sunetra 
Published: April 2015

AbstractWe identified 2‐phenylisophosphindoline 2‐oxide as a suitable and potentially tunable catalyst for the catalytic Wittig reaction of aldehydes with activated organohalides. This catalyst was obtained by a straightforward two‐step synthesis. Trimethoxysilane proved to be an efficient reducing agent for the in situ generation and regeneration of the catalyst from the corresponding phosphane oxide. Sodium carbonate was identified as a suitable base for the transformation. It is noteworthy that the particle size of the sodium carbonate had a tremendous effect on the outcome of the reaction. Under the optimized reaction conditions, 23 aldehydes were converted into the corresponding alkenes in high isolated yields of up to 88 %. Moreover, an asymmetric catalytic Wittig reaction was performed for the desymmetrization of a prochiral diketone.
Synthesis of Diiodinated Biphenyls and Iodinated meta‐Terphenyls by Regioselective Suzuki–Miyaura Cross‐Coupling Reactions of 5‐Substituted 1,2,3‐Triiodobenzenes
Authors: Al‐Zoubi Raed M. , Al‐Jammal Walid K. , El‐Khateeb Mohammad Y. , McDonald Robert 
Published: April 2015

AbstractA variety of 2,3‐diiodinated biphenyl and iodinated meta‐terphenyl derivatives were synthesized by a regioselective Suzuki–Miyaura cross‐coupling reaction of 5‐substituted 1,2,3‐triiodobenzenes. By using 1 equiv. of arylboronic acid, the Suzuki–Miyaura reaction yielded 2,3‐diiodinated biphenyl derivatives with excellent regioselectivity. The coupling reaction predominantly occurred at the terminal position of the 5‐substituted 1,2,3‐triiodobenzene, which is the less sterically hindered and more electronically deficient site. With 2 equiv. of arylboronic acids, the one‐pot reaction provided iodinated meta‐terphenyls in good yields. This facile and efficient one‐step method is also quite general in scope as well as scalable.
Electropolymerized Eugenol‐MWNT‐Based Electrode for Voltammetric Evaluation of Wine Antioxidant Capacity
Authors: Ziyatdinova Guzel , Kozlova Ekaterina , Budnikov Herman 
Published: April 2015

AbstractEugenol electropolymerization conditions on multiwalled carbon nanotube based glassy carbon electrode (MWNT/GCE) have been found. The polyeugenol/MWNT/GCE shows reversible redox steps of o‐quinone fragment in acidic media. Natural phenolic antioxidants are oxidized on polyeugenol/MWNT/GCE at 0.52 V excluding resveratrol (0.62 V). Differential pulse voltammetry on polyeugenol/MWNT/GCE was applied for the evaluation of wine antioxidant capacity (AOC). The AOC was expressed in catechin equivalents per 1 L of wine. The linear dynamic range is 1.00–250 µM with LOD and LOQ of 0.21 and 0.71 µM of catechin, respectively. Positive correlations for AOC with antioxidant activity (r=0.9840) and total phenolics content (r=0.9944) were observed.
Simple, Rapid and Sensitive Electrochemical Method for the Determination of the Triketone Herbicide Sulcotrione in River Water Using a Glassy Carbon Electrode
Authors: Stanković Dalibor M. , Mehmeti Eda , Svorc Lubomir , Kalcher Kurt 
Published: April 2015

AbstractWe report a novel, simple, rapid and sensitive electrochemical method for the determination of sulcotrione, a member of the relatively new class of triketone herbicides, using differential pulse voltammetry on a glassy carbon electrode. Its electrochemical behavior including influences of electrolyte composition, pH and scan rate was studied to select optimal experimental parameters for its determination. In BrittonRobinson buffer at pH 3 sulcotrione provided a well‐defined reduction peak at −0.84 V (vs. Ag/AgCl electrode), with good repeatability (relative standard deviation of 2.3 % for 8 measurements at 10 µM concentration level). With optimized parameters differential pulse voltammetry rendered two linear concentration ranges from 0.2 to 2 µM and from 2 to 50 µM with a detection limit of 0.05 µM. The proposed procedure was successfully applied to the determination of sulcotrione in spiked river water samples with satisfactory recoveries (93–109 %). The developed method may represent a simple, rapid and sensitive alternative to highly toxic mercury electrodes and chromatographic methods.
Contact sensitization to fragrance mix I and II, to Myroxylon pereirae resin and oil of tupentine: multifactorial analysis of risk factors based on data of the IVDK network
Authors: Uter Wolfgang , Fieβler Cornelia , Gefeller Olaf , Geier Johannes , Schnuch Axel 
Published: April 2015

AbstractFragrances are among the most common contact sensitizers. Changes in exposure lead to subsequent changes of sensitization incidence; patterns of exposure may be reflected in certain surrogate markers such as affected anatomical site or occupation. The objective of this study was to provide current results on sensitization prevalences to the fragrance allergy screening markers of the patch test baseline series, on time trends and on risk factors associated with sensitization. Data of all patients tested between 1999 and 2012 with fragrance mix I (8% petrolatum (pet.) n = 130 325), fragrance mix II (14% pet., since 2005, n = 81 290), Myroxylon pereirae resin (25% pet., n = 130 258) and oil of turpentine (10% pet., n = 131 595), respectively, in the Information Network of Departments of Dermatology (IVDK, www.ivkd.org) were subject to descriptive and log‐binomial regression analysis. Overall, 16.31% of patients had a positive patch test reaction to at least one of the four markers. The prevalence to each of the four single markers was 8.71, 4.87, 8.36 and 1.95%. A peculiar downward trend of FM I until around 2006/2007 with subsequent increase, both significant, was noted. Mostly, sensitization risk was higher in older patients and females, and was to a varying extent associated with certain anatomical sites. The mostly stable or even increasing time trends warrant further in‐depth research into causative exposures, addressing the effectiveness of (self‐) regulation, aggregate exposure and ‘cocktail effect’. Copyright © 2015 John Wiley & Sons, Ltd.
Kernel Approach for Modeling Interaction Effects in Genetic Association Studies of Complex Quantitative Traits
Authors: Broadaway K. Alaine , Duncan Richard , Conneely Karen N. , Almli Lynn M. , Bradley Bekh , Ressler Kerry J. , Epstein Michael P. 
Published: April 2015

ABSTRACTThe etiology of complex traits likely involves the effects of genetic and environmental factors, along with complicated interaction effects between them. Consequently, there has been interest in applying genetic association tests of complex traits that account for potential modification of the genetic effect in the presence of an environmental factor. One can perform such an analysis using a joint test of gene and gene‐environment interaction. An optimal joint test would be one that remains powerful under a variety of models ranging from those of strong gene‐environment interaction effect to those of little or no gene‐environment interaction effect. To fill this demand, we have extended a kernel machine based approach for association mapping of multiple SNPs to consider joint tests of gene and gene‐environment interaction. The kernel‐based approach for joint testing is promising, because it incorporates linkage disequilibrium information from multiple SNPs simultaneously in analysis and permits flexible modeling of interaction effects. Using simulated data, we show that our kernel machine approach typically outperforms the traditional joint test under strong gene‐environment interaction models and further outperforms the traditional main‐effect association test under models of weak or no gene‐environment interaction effects. We illustrate our test using genome‐wide association data from the Grady Trauma Project, a cohort of highly traumatized, at‐risk individuals, which has previously been investigated for interaction effects.
Physical Organic ChemistryDevelopment and Perspectives
Authors: Mayr Herbert 
Published: April 2015

AbstractOriginal documents by L. P. Hammett and C. K. Ingold are presented which elucidate the origin of physical organic chemistry in the late 1920s and early 1930s. The field gained fast popularity, and within four decades created the presently accepted mechanistic model of organic chemistry. As the focus of research in organic chemistry shifted to synthesis around 1970, physical organic chemistry lost visibility, though mechanistic investigations became integral aspects of synthetic method development. While important subdisciplines of physical organic chemistry, e. g., supramolecular chemistry or mechanistic enzymology, continued to develop under separate headings, the systematic use of newly developed techniques (gas phase chemistry, laser spectroscopy, matrix isolation) is expected to lead to a renaissance of classical physical organic chemistry.
Digital Game‐Based Learning
Authors: Spires Hiller A. 
Published: April 2015

AbstractJust as literacy practices are contextualized in social situations and relationships, game players establish shared language and understandings within a game; in essence, they gain fluency in specialized languages. This commentary explores the importance of digital game‐based learning for schooling, the relationship between game‐based learning, and results from Crystal Island, a NSF‐funded research project on digital gameplay. Suggestions for how teachers can use games in the classroom are highlighted.
Physicochemical properties and responses in microcirculation of native tapioca starch‐based plasma expander
Authors: Chatpun Surapong , Meesane Jirut , Rujirojindakul Pairaya 
Published: April 2015

AbstractPlasma expanders (PEs) such as hydroxyethyl strach are widely used for volume replacement. The plantation and production of tapioca in Thailand is abundant which may provide a new source for PEs starch with novel properties. This work investigated the properties and circulatory effects of native tapioca starch‐based PE (TPE). Various formulations of mixture between native tapioca starch and 0.9% sodium chloride solution were prepared and characterized in order to obtain the proper physicochemical and rheological properties. About 1% concentration by weight per volume of TPE was compared with 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride (HES130/0.4) using an acute hemodilution by 40% of blood volume in an animal protocol. TPE had higher turbidity and viscosity but lower colloid osmotic pressure compared with HES 130/0.4. The in vivo study demonstrated that Golden Syrian hamsters hemodiluted with TPE maintained a mean arterial blood pressure and no significant difference compared to HES 130/0.4. The arterial vasodilation and functional capillary density in the animals hemodiluted with TPE had higher values than in the animals hemodiluted with HES 130/0.4. Although the in vivo study reported positive results using this native tapioca starch‐based PE, the product needs work to improve some of its physiochemical properties. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 395–401, 2016.
Soft hydrogels interpenetrating silicone—A polymer network for drug‐releasing medical devices
Authors: Steffensen Søren L. , Vestergaard Merete H. , Møller Eva H. , Groenning Minna , Alm Martin , Franzyk Henrik , Nielsen Hanne M. 
Published: April 2015

AbstractMaterials for the next generation of medical devices will require not only the mechanical stability of current devices, but must also possess other properties such as sustained release of drugs in a controlled manner over a prolonged period of time. This work focuses on creating such a sophisticated material by forming an interpenetrating polymer network (IPN) material through modification of silicone elastomers with a poly(2‐hydroxyethyl methacrylate) (PHEMA)‐based hydrogel. IPN materials with a PHEMA content in the range of 13%–38% (w/w) were synthesized by using carbon dioxide‐based solvent mixtures under high pressure. These IPNs were characterized with regard to microstructure as well as ability of the hydrogel to form a surface‐connected hydrophilic carrier network inside the silicone. A critical limit for hydrogel connectivity was found both via simulation and by visualization of water uptake in approximately 25% (w/w) PHEMA, indicating that entrapment of gel occurs at low gel concentrations. The optimized IPN material was loaded with the antibiotic ciprofloxacin, and the resulting drug release was shown to inhibit bacterial growth when placed on agar, thus demonstrating the potential of this IPN material for future applications in drug‐releasing medical devices. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 402–410, 2016.