bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asian Monsoon Forcing of Subtropical Easterlies in the Community Atmosphere Model: Summer Climate Implications for the Western Atlantic
Authors: Kelly Patrick , Mapes Brian 
Published: October 2012

Abstract
The effects of a progressively enhanced Asian summer monsoon on the mean zonal wind are examined in a series of experiments using the Community Atmosphere Model version 4 (CAM4). The response of the barotropic mean zonal wind varies in a linear fashion with the forcings of 5, 10, and 20 W m−2 in net radiation over South Asia. The authors increase the strength of the monsoon by making the South Asian land surface hotter (via lower soil albedo). This leads to an enhanced Rossby wave source region over the Balkan Peninsula at 45°N, northwest of the upper-level Tibetan high (TH). Equatorward propagation of Rossby waves causes stationary eddy momentum flux divergence (SEMFD) to the south of this source region. This local area of SEMFD produces easterly tendencies of the barotropic part of the mean zonal wind in the subtropics. As the easterly mean flow strengthens, so do low-level easterlies across the subtropical Atlantic, leading to a westward displacement of the North Atlantic subtropical high (NASH) on its equatorward flank. The western intensification of the NASH causes drying in the west Atlantic and neighboring land masses primarily because of near-surface wind divergence in the anticyclone. These modeling results confirm the mechanisms deduced in the authors’ recent observational analysis of the mean seasonal cycle’s midsummer drought.
Austral Summer Teleconnections of Indo-Pacific Variability: Their Nonlinearity and Impacts on Australian Climate
Authors: Cai Wenju , van Rensch Peter 
Published: October 2012

Abstract
In austral summer, El Niño–Southern Oscillation (ENSO) covaries with the Indian Ocean Basin Mode (IOBM) and with the southern annular mode (SAM). The present study addresses how the IOBM and the SAM modulate the impact of ENSO on Australia. The authors show that the modulating effect of the SAM is limited; in particular, the SAM does not modify the ENSO teleconnection pattern. However, the IOBM extends ENSO-induced convection anomalies westward over northern Australia and over the eastern Indian Ocean, whereby extending the ENSO tropical teleconnection to the northwest of Australia. The IOBM also generates an equivalent-barotropic Rossby wave train through convection anomalies over northern Australia. The wave train shares an anomaly center over the Tasman Sea latitudes with the Pacific–South American (PSA) pattern, shifting the anomaly center of the PSA pattern to within a closer proximity to Australia. There is a strong asymmetry in the IOBM modulating effect. During an IOBM negative phase, which tends to coincide with La Niña events, the rainfall increase is far greater than the reduction during a positive IOBM phase, which tends to coincide with El Niño events. This modulation asymmetry is consistent with an asymmetry in the ENSO–rainfall teleconnection over Australia, in which the La Niña–rainfall teleconnection is stronger than the El Niño–rainfall teleconnection. This asymmetric ENSO–rainfall teleconnection ensures a higher coherence of northern Australia convective anomalies with La Niña or with a negative phase of the IOBM, hence a greater modification of the PSA pattern, underpinning the asymmetric modulating role of the IOBM.
On the Role of Coastal Troughs in the Circulation of Warm Circumpolar Deep Water on Antarctic Shelves
Authors: St-Laurent Pierre , Klinck John M. , Dinniman Michael S. 
Published: October 2012

Abstract
Oceanic exchanges across the continental shelves of Antarctica play an important role in biological systems and the mass balance of ice sheets. The focus of this study is on the mechanisms responsible for the circulation of warm Circumpolar Deep Water (CDW) within troughs running perpendicular to the continental shelf. This is examined using process-oriented numerical experiments with an eddy-resolving (1 km) 3D ocean model that includes a static and thermodynamically active ice shelf. Three mechanisms that create a significant onshore flow within the trough are identified: 1) a deep onshore flow driven by the melt of the ice shelf, 2) interaction between the longshore mean flow and the trough, and 3) interaction between a Rossby wave along the shelf break and the trough. In each case the onshore flow is sufficient to maintain the warm temperatures underneath the ice shelf and basal melt rates of O(1 m yr−1). The third mechanism in particular reproduces several features revealed by moorings from Marguerite Trough (Bellingshausen Sea): the temperature maximum at middepth, a stronger intrusion on the downstream edge of the trough, and the appearance of warm anticyclonic anomalies every week. Sensitivity experiments highlight the need to properly resolve the small baroclinic radii of these regions (5 km on the shelf)—simulations at 3-km resolution cannot reproduce mechanism 3 and the associated heat transport.
Sleep disturbance, personality and the onset of depression and anxiety: Prospective cohort study
Authors: Batterham Philip J , Glozier Nicholas , Christensen Helen 
Published: October 2012

Objective: Previous studies have shown associations between sleep disturbance and the onset of depression and anxiety. However, this relationship may reflect an underlying vulnerability, such as temperament or cognitive style, which accounts for an association between the two. This study aimed to evaluate the relationship between sleep disturbance and the onset of a mental disorder after a 4-year follow-up, and whether this was accounted for by ruminative style and neuroticism. Method: The nine-item Patient Health Questionnaire was used to assess the criteria for major depression, generalized anxiety disorder (GAD) and panic disorder (PD) in a community cohort of 3636 young and middle-aged Australian adults, free of any disorder at baseline, over a 4-year period. Sleep disturbance was based on a factor derived from the sleep items of the Goldberg Depression and Anxiety Scales. The associations between baseline sleep disturbance and a new episode of the assessed disorders were estimated and the impact of temperament and cognitive style on these associations was evaluated. Results: Self-reported sleep disturbance was significantly associated with an onset of major depressive disorder [MDD; odds ratio (OR) = 1.33, p = 0.006], GAD (OR = 1.37, p < 0.001) and PD (OR = 1.62, p < 0.001) after 4 years. However, the relationship for MDD was attenuated to nonsignificance (OR = 1.19, p = 0.116) after adjusting for neuroticism (measured by the Eysenck Personality Questionnaire-Revised) and rumination (measured by the adapted Ruminative Style scale). Conclusions: These data suggest that the often-observed association between sleep disturbance and depression onset may be linked to an underlying ruminative style and/or neuroticism. However, the fact that the effect of sleep disturbance on PD and GAD onset was not accounted for by personality factors is a novel finding and suggests a potential role of early identification in selective preventive interventions.
The impact of depression heterogeneity on cognitive control in major depressive disorder
Authors: Quinn Candice R , Harris Anthony , Felmingham Kim , Boyce Philip , Kemp Andrew 
Published: October 2012

Objective: Depressed patients display a variety of deficits in neuropsychological function, and contradictory findings in the literature may be due to disorder heterogeneity. The aim of this study was to examine the impact of severity, subtype and symptoms on cognitive control. Methods: Neuropsychological function across a range of cognitive control tasks was examined in melancholic ( n = 65) and non-melancholic depressed patients ( n = 59) relative to controls ( n = 124). The relationship between subtype (melancholia vs non-melancholia) and anxiety was also examined. Results: Melancholia was characterised by attention and working memory deficits typically associated with the dorsolateral prefrontal cortex, while non-melancholia was characterised by verbal memory recall deficits indicative of left frontal lobe and medial temporal lobe function. The severity of anxious arousal and psychomotor disturbance contributed to cognitive impairment more than the severity of depression symptoms and anxious apprehension. Conclusions: Findings highlight a differential impact of depression subtype and severity, and suggest that anxious arousal and psychomotor disturbance may contribute to poorer performance on neuropsychological tasks associated with dorsolateral prefrontal cortex function.
Intraperitoneal influx of neutrophils in response to IL-33 is mast cell–dependent
Authors: Enoksson Mattias , Möller-Westerberg Christine , Wicher Grzegorz , Fallon Padraic G. , Forsberg-Nilsson Karin , Lunderius-Andersson Carolina , Nilsson Gunnar 
Published: October 2012

Abstract
IL-33 is a recently discovered cytokine involved in induction of Th2 responses and functions as an alarmin. Despite numerous recent studies targeting IL-33, its role in vivo is incompletely understood. Here we investigated inflammatory responses to intraperitoneal IL-33 injections in wild-type and mast cell–deficient mice. We found that wild-type mice, but not mast cell–deficient Wsh/Wsh mice, respond to IL-33 treatment with neutrophil infiltration to the peritoneum, whereas other investigated cell types remained unchanged. In Wsh/Wsh mice, the IL-33–induced innate neutrophil response could be rescued by local reconstitution with wild-type but not with T1/ST2−/− mast cells, demonstrating a mast cell–dependent mechanism. Furthermore, we found this mechanism to be partially dependent on mast cell–derived TNF, as we observed reduced neutrophil infiltration in Wsh/Wsh mice reconstituted with TNF−/− bone marrow–derived mast cells compared with those reconstituted with wild-type bone marrow–derived mast cells. In agreement with our in vivo findings, we demonstrate that humanneutrophils migrate toward the supernatant of IL-33–treated human mast cells. Taken together, our findings reveal that IL-33 activates mast cells in vivo to recruit neutrophils, a mechanism dependent on IL-33R expression on peritoneal mast cells. Mast cells activated in vivo by IL-33 probably play an important role in inflammatory reactions.
Combination coating of chitosan and anti-CD34 antibody applied on sirolimus-eluting stents can promote endothelialization while reducing neointimal formation
Authors: Yang Feng , Feng Shi-Chao , Pang Xiang-Jun , Li Wei-Xiao , Bi Yong-Hua , Zhao Qian , Zhang Shi-Xuan , Wang Yang , Feng Bo 
Published: October 2012

AbstractBackgroundCirculating endothelial progenitor cells (EPCs) capture technology improves endothelialization rates of sirolimus-eluting stents (SES), but the problem of delayed re-endothelialization, as well as endothelial dysfunction, has still not been overcome. Therefore, we investigated whether the combination coating of hyaluronan-chitosan (HC) and anti-CD34 antibody applied on an SES (HCASES) can promote endothelialization, while reducing neointimal formation and inflammation.MethodsSirolimus-eluting stents(SES), anti-CD34 antibody stents (GS) and HC-anti-CD34 antibody combined with sirolimus-eluting stents (HCASES) were deployed in 54 normal porcine arteries and harvested for scanning electron microscopy (SEM) and histological analysis. The ratio of endothelial coverage above the stents was evaluated by SEM analysis at 7, 14 and 28 days. The percentage of in-stent stenosis was histologically analyzed at 14 and 28 days.ResultsSEM analysis at 7 days showed that endothelial strut coverage was increased in the HCASES group (68±7%) compared with that in the SES group (31±4%, p=0.02). At 14 days, stent surface endothelialization, evaluated by SEM, showed a significantly higher extent of endothelial coverage above struts in the GS (95 ± 2%) and the HCASES groups (87±4%) compared with that in the SES group (51±6%, p=0.02). Histological examination showed that the percentage of stenosis in the HCASES group was not significantly different to that of the SES and GS groups (both p> 0.05). At 28 days, there was no difference in the rates of endothelial coverage between the HCASES and GS groups. The HCASES group showed less stenosis than that in the GS group (P < 0.05), but it was not significantly different from the SES group (P=0.068).ConclusionsSEM and histology demonstrated that HCASESs can promote re-endothelialization while enhancing antiproliferative effects.
Analysis of the clinical relevance of antimitochondrial antibodies to the β- and γ-subunits of the F1F0-ATPase in patients with primary biliary cirrhosis
Authors: Nann Dominik , Berg Christoph P , Preuß Beate E , Klein Reinhild 
Published: October 2012

AbstractBackgroundIn a recent study we showed that in patients with primary biliary cirrhosis (PBC) being positive or negative for anti-M2 antibodies reacting with the 2-oxoacid-dehydrogenase complex (ODC) also antibodies to the beta- and gamma-subunits of F1F0-ATPase (anti-β, anti-γ) occur. This is a mitochondrial enzyme but parts are also expressed on plasma membranes of endothelial cells. Here we wanted to analyse in more detail their clinical relevance.MethodsFifty-nine untreated and histologically defined PBC patients who had been followed for at least five years were included into the study (51 anti-M2 positive, 8 anti-M2 negative). Twenty-three of them were treated in the follow up with ursodeoxycholic acid (UDCA), eight received during a trial methotrexate (MTX). In 13 patients orthotopic liver transplantation (OLT) had to be performed. Serum samples before and during therapy were available. Patients were analysed with respect to laboratory parameters, disease activity and histological stages.Patients’ sera were tested by ELISA for IgG- and IgM-antibodies against the beta- and gamma-subunits which had been recombinant expressed inE.coliand highly purified by electro-elution from SDS-gels after electrophoresis.ResultsFifty-nine percent of the anti-M2 positive and 50% of the anti-M2 negative PBC patients had anti-β- and/or anti-γ-antibodies. There were no differences between anti-β- and/or anti-γ-antibody positive or negative patients with respect to biochemical parameters, immunoglobulins, histological stages or disease activity. Antibody reactivity significantly decreased during UDCA and MTX-treatment and also after OLT.ConclusionsAntibodies to the β- and γ-subunits of F1F0-ATPase occur in anti-M2 positive and –negative PBC but do not have any relevance with respect to clinical activity or prognosis. However, in contrast to the anti-M2 antibodies they decrease during UDCA and immunosuppressive therapy.
miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells
Authors: Gong Ai-Yu , Eischeid Alex N , Xiao Jing , Zhao Jian , Chen Dongqing , Wang Zhao-Yi , Young Charles YF , Chen Xian-Ming 
Published: October 2012

Abstract

Background
Androgen receptor (AR) signalling is critical to the initiation and progression of prostate cancer (PCa). Transcriptional activity of AR involves chromatin recruitment of co-activators, including the p300/CBP-associated factor (PCAF). Distinct miRNA expression profiles have been identified in PCa cells during the development and progression of the disease. Whether miRNAs regulate PCAF expression in PCa cells to regulate AR transcriptional activity is still unclear.

Methods
Expression of PCAF was investigated in several PCa cell lines by qRT-PCR, Western blot, and immunocytochemistry. The effects of PCAF expression on AR-regulated transcriptional activity and cell growth in PCa cells were determined by chromatin immunoprecipitation, reporter gene construct analysis, and MTS assay. Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay.

Results
PCAF was upregulated in several PCa cell lines. Upregulation of PCAF promoted AR transcriptional activation and cell growth in cultured PCa cells. Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p. Targeting of the 3’-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation, and, consequently, modulation of AR transcriptional activity in PCa cells.

Conclusions
PCAF is upregulated in cultured PCa cells, and upregulation of PCAF is associated with the downregulation of miR-17-5p. Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells.
What are the effects of having an illness or injury whilst deployed on post deployment mental health? A population based record linkage study of UK Army personnel who have served in Iraq or Afghanistan
Authors: Forbes Harriet J , Jones Norman , Woodhead Charlotte , Greenberg Neil , Harrison Kate , White Sandra , Wessely Simon , Fear Nicola T 
Published: October 2012

Abstract

Background
The negative impact of sustaining an injury on a military deployment on subsequent mental health is well-documented, however, the relationship between having an illness on a military operation and subsequent mental health is unknown.

Methods
Population based study, linking routinely collected data of attendances at emergency departments in military hospitals in Iraq and Afghanistan [Operational Emergency Department Attendance Register (OpEDAR)], with data on 3896 UK Army personnel who participated in a military health study between 2007 and 2009 and deployed to Iraq or Afghanistan between 2003 to 2009.

Results
In total, 13.8% (531/3896) of participants had an event recorded on OpEDAR during deployment; 2.3% (89/3884) were medically evacuated. As expected, those medically evacuated for an injury were at increased risk of post deployment probable PTSD (odds ratio 4.27, 95% confidence interval 1.80-10.12). Less expected was that being medically evacuated for an illness was also associated with a similarly increased risk of probable PTSD (4.39, 1.60-12.07) and common mental disorders (2.79, 1.41-5.51). There was no association between having an OpEDAR event and alcohol misuse. Having an injury caused by hostile action was associated with increased risk of probable PTSD compared to those with a non-hostile injury (3.88, 1.15 to 13.06).

Conclusions
Personnel sustaining illnesses on deployment are just as, if not more, at risk of having subsequent mental health problems as personnel who have sustained an injury. Monitoring of mental health problems should consider those with illnesses as well as physical injuries.
Developing standards for malaria microscopy: external competency assessment for malaria microscopists in the Asia-Pacific
Authors: Ashraf Sania , Kao Angie , Hugo Cecilia , Christophel Eva M , Fatunmbi Bayo , Luchavez Jennifer , Lilley Ken , Bell David 
Published: October 2012

Abstract

Background
Malaria diagnosis has received renewed interest in recent years, associated with the increasing accessibility of accurate diagnosis through the introduction of rapid diagnostic tests and new World Health Organization guidelines recommending parasite-based diagnosis prior to anti-malarial therapy. However, light microscopy, established over 100 years ago and frequently considered the reference standard for clinical diagnosis, has been neglected in control programmes and in the malaria literature and evidence suggests field standards are commonly poor. Microscopy remains the most accessible method for parasite quantitation, for drug efficacy monitoring, and as a reference of assessing other diagnostic tools. This mismatch between quality and need highlights the importance of the establishment of reliable standards and procedures for assessing and assuring quality. This paper describes the development, function and impact of a multi-country microscopy external quality assurance network set up for this purpose in Asia.

Methods
Surveys were used for key informants and past participants for feedback on the quality assurance programme. Competency scores for each country from 14 participating countries were compiled for analyses using paired sample t-tests. In-depth interviews were conducted with key informants including the programme facilitators and national level microscopists.

Results
External assessments and limited retraining through a formalized programme based on a reference slide bank has demonstrated an increase in standards of competence of senior microscopists over a relatively short period of time, at a potentially sustainable cost. The network involved in the programme now exceeds 14 countries in the Asia-Pacific, and the methods are extended to other regions.

Conclusions
While the impact on national programmes varies, it has translated in some instances into a strengthening of national microscopy standards and offers a possibility both for supporting revival of national microcopy programmes, and for the development of globally recognized standards of competency needed both for patient management and field research.
A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition
Authors: Masola Valentina , Onisto Maurizio , Zaza Gianluigi , Lupo Antonio , Gambaro Giovanni 
Published: October 2012

Abstract

Background
Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). The signaling of FGF-2, a growth factor involved in this mechanism, is regulated by glycosaminoglycans. Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition. Well known Heparanase-1 inhibitors are heparin(s) and sulodexide, a low-molecular weight heparin – dermatan sulphate blend, which is effective in the treatment of DN.

Methods
We have investigated the inhibition by sulodexide and its components of Heparanase-1 by an ELISA assay. We have analyzed its effect on the epithelial-mesenchymal transition of tubular cells by real time gene expression analysis, zymography and migration assay.

Results
Results show that sulodexide is an effective heparanase-1 inhibitor, exclusively in virtue to the heparin component, with an IC50 of 5 μg/ml. In FGF-2 treated tubular cells, sulodexide also prevents the over-expression of the mesenchymal markers αSMA, vimentin and fibronectin and the motility increase, i.e. the epithelial-mesenchymal transition of tubular cells. Moreover, sulodexide prevents FGF-2 induced heparanase-1 and MMP9 increase switching off the autocrine loop that FGF-2 activates to support its signal.

Conclusions
The findings highlight the capacity of sulodexide to inhibit heparanase-1 and to control tubular fibrosis triggered by epithelial-mesenchymal transition. In conclusion, these sulodexide activities support the value of this agent in controlling the progression of nephropathy to renal failure.
Quantitative study of GaAs nanowires catalyzed by Au film of different thicknesses
Authors: Xu Hong-yi , Guo Ya-nan , Sun Wen , Liao Zhi-ming , Burgess Timothy , Lu Hao-feng , Gao Qiang , Tan Hark Hoe , Jagadish Chennupati , Zou Jin 
Published: October 2012

Abstract
In this letter, we quantitatively investigated epitaxial GaAs nanowires catalyzed by thin Au films of different thicknesses on GaAs (111)B substrates in a metal-organic chemical vapor deposition reactor. Prior to nanowire growth, the de-wetting of Au thin films to form Au nanoparticles on GaAs (111)B in AsH3 ambient at different temperatures is investigated. It is found that with increasing film thickness, the size of the Au nanoparticles increases while the density of the nanoparticles reduces. Furthermore, higher annealing temperature produces larger Au nanoparticles for a fixed film thickness. As expected, the diameters and densities of the as-grown GaAs nanowires catalyzed by these thin Au films reflect these trends.