bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardization of Inpatient Hypertension Management
Authors: Krishna Lavu Vamsi , Aldaoud Nour , Salvi Dhairya , Yesilyaprak Abdullah , Tegeltija Vesna 
Published: August 2024

Introduction: Hypertension is a frequent occurrence during hospitalization and physicians are routinely called to treat hypertensive events despite the asymptomatic nature of patients. Although guidelines about outpatient management of hypertension are available, management strategies for asymptomatic inpatient hypertension are lacking. Without a standardized approach, physicians treat asymptomatic hypertension utilizing inconsistent strategies including intravenous antihypertensives (IVAHs). The use of IVAHs has shown to have adverse effects that are associated with increased morbidity and mortality. Aim: The aim of this project is to standardize the approach to inpatient asymptomatic hypertension and minimize use of IVAHs by 25% in 6 months. Method: Using the IHI Model, a quality improvement project was initiated. Root cause analysis revealed a lack of standard approach to managing asymptomatic hypertension. For PDSA 1, a standardized approach algorithm was created, and residents were educated about criteria for assessing symptoms, any contributing factors/secondary hypertension and if they had a history of hypertension/home meds. For PDSA 2, we expanded education for the nursing staff and provided them with the treatment flowchart. We also included the pharmacy department in our initiative, to form a multidisciplinary approach. For PDSA 3, we included Nurse Practitioners in our education. Results: Prior to PDSA 1, 24 charts were analysed and over 58% of patients (14/24) had received inappropriate IVAHs. Post-intervention, 31 charts were analysed and showed a 32.5 % reduction in IVAH use. Prior to PDSA 2, another 36 patient charts were analysed and 25% of patients had received inappropriate IVAHs. Post-intervention, 21 charts were analysed and showed an 11 % reduction in IVAH use. For PDSA 3, 53% of patients had received inappropriate IVAHs. Which reduced by 11% post intervention. Our post-intervention analysis is ongoing, and although data suggests a promising decrease in the use of inappropriate IVAHs, it has been inconsistent, and sustainability will become a challenge. Conclusion/Next Steps: Our project led to the implementation of a standardized algorithm, thus decreasing inappropriate use of IVAHs and minimizing cost. Management of asymptomatic hypertension in the hospital begins with addressing contributing factors such as pain or anxiety, then reviewing held home medication. With the implementation of a standardized algorithm, we found some success in the reduction of use of IVAHs. Our next steps include implementing the algorithm in the EMR system to have an alert system to clarify when IVAHs are indicated and when other options should be reviewed. We plan to continue our multidisciplinary efforts with the pharmacy and EMR staff along with new admission PA/NP service. Re-education throughout the year will also be implemented to improve sustainability.
Development of Smart Pocket Learning Media to Improve the Ability to Recognize Number Concepts in Children Aged 5-6 Years
Authors: Delpiyani Delpiyani , Tabroni Imam , Brunel Benjamin , Alan Milton 
Published: August 2024

This study aims to produce valid Smart Pocket learning media to improve symbolic thinking skills in children aged 5-6 years. This research is a development research with the development model used by Sugiyono. In this study, researchers only used 7 (seven) stages, namely knowing problems and potential, data collection, product design, design validation, design revision, product trials and product manufacturing. The next stage was not carried out due to cost and time constraints. The data collection technique used is a questionnaire, where the questionnaire is validated by material experts, media experts and educators. The type of data generated is quantitative and qualitative data. The average percentage result of the pretest conducted on 3 children is 10.3%, proving that the child's condition is still in the stage of starting to develop. Then the posttest is carried out, namely the condition after the child is given Smart Pocket media, the average percentage result of this posttest is 16% which proves that the child has changed the condition to develop as expected. So it can be concluded that Smart Pocket media to improve the ability to think symbollically for children aged 5-6 years has met the criteria for validity.
Application of K-Means Clustering Algorithm to Obtain Recommendations for Strategies to Increase the Number of Students in the Information Systems Study Program at ITB Ahmad Dahlan Jakarta
Authors: Yusuf Diana , Guilin Xie , Jiao Deng 
Published: August 2024

The rapid development of technology today has almost touched all sectors of life such as the economy, health and education. The technology currently used produces a lot of data every day, one of which is in the field of education. Data mining is a group of methods used to investigate and reveal complex relationships in very large data sets. Data here means information organized in a tabular format, as is often used in relational database management. This research uses data from the academic section of ITB Ahmad Dahlan, namely data on students of the Information Systems study program from 2019 to 2022. The attributes that will be used for this research are student gender, student employment status and student achievement index. Recommendations for promotional strategies to increase the number of new students are to conduct visits to high schools or vocational schools. Not only that, the new student admission team can also promote to companies or offices.
Pengaruh Budaya Organisasi Dan Pengembangan Karir Terhadap Prestasi Kerja Pegawai Pada Dinas PUPR Kabupaten Bima
Authors: Putri Mildan , Wulandari Wulandari 
Published: August 2024

Penelitian ini meneliti masalah : 1) masih adanya pegawai sering datang terlambat masuk kerja. 2) masih adanya pegawai tidak memakai seragam yang sudah ditetapkan. 3) masih ada pegawai belum puas terhadap pekerjaan yang dilakukan. 4) adanya pegawai yang belum memiliki kualitas kerja meliputi ketepatan dan ketelitian pegawai dalam melaksanakan pekerjaannya. Tujuan penelitian untuk mengetahui adakah pengaruh positif dan signifikan budaya organisasi dan pengembangan karir terhadap prestasi pegawai pada Dinas PUPR Kabupaten Bima. Metode penelitian yaitu kuantitatif. Hasil penelitian analisis persamaan regresi berganda = ý = 46.003 + 0,293 (χ1) + 0,285 (χ2). Dan uji statistik secara parsial χ1 didapati t-hit> t-tabel atau 2.179 > 1.997 sig sebesar 0,033 < 0,05. Berarti h1 diterima, disimpulkan terdapat pengaruh positif dan sig budaya organisasi terhadap prestasi kerja . Untuk χ2 = t-hit< t-tab atau –0,562 < 1.997 dan sig sebesar 0,123 > 0,05 berarti h2 ditolak, berarti tidak terdapat pengaruh positif dan signifikan pengembangan karir terhadap prestasi kerja. Untuk uji f secara simultan f hitung < f tabel = 2,384 < 3,13 dan nilai sig yaitu 0,100 > 0,05 sehingga hipotesis h3 ditolak, disimpulkan budaya organisasi dan pengembangan karir tidak berpengaruh positif dan signifikan terhadap prestasi kerja pegawai pada Dinas PUPR Kabupaten Bima.
SUJEITO E CIDADE: apontamentos sobre a restauração da cidade subjetiva
Authors: Rodrigues Rogério 
Published: August 2024

O objetivo deste ensaio busca colocar em debate o conceito contemporâneo de subjetividade, a partir de Felix Guattari (2000), o qual coloca em evidência as dificuldades da restauração da cidade subjetiva. O modelo de desenvolvimento e de tecnologias tem produzido a cidade na distopia como lugar de pouca ou nenhuma sustentabilidade, em que prevalece a lógica especulativa de mercado. Neste contexto, o sujeito perde a relação com o espaço e compreende a cidade apenas como instrumento para locomoção, moradia, trabalho e formas de consumo, portanto, destituído completamente de elementos reflexivos com o lugar. A metodologia utilizada neste ensaio encontra-se no campo da teoria crítica, tomando como aporte teórico a Filosofia da Educação, como forma de interpretar os processos formativos. A nossa conclusão se refere diretamente em apresentar a nossa dificuldade em realizar a ruptura desse modelo de cidade instrumental, que segmenta a relação do sujeito com o espaço da cidade.
Predicting student success in MOOCs: a comprehensive analysis using machine learning models
Authors: Althibyani Hosam A. 
Published: August 2024

Background
This study was motivated by the increasing popularity of Massive Open Online Courses (MOOCs) and the challenges they face, such as high dropout and failure rates. The existing knowledge primarily focused on predicting student dropout, but this study aimed to go beyond that by predicting both student dropout and course results. By using machine learning models and analyzing various data sources, the study sought to improve our understanding of factors influencing student success in MOOCs.

Objectives
The primary aim of this research was to develop accurate predictions of students’ course outcomes in MOOCs, specifically whether they would pass or fail. Unlike previous studies, this study took into account demographic, assessment, and student interaction data to provide comprehensive predictions.

Methods
The study utilized demographic, assessment, and student interaction data to develop predictive models. Two machine learning methods, logistic regression, and random forest classification were employed to predict students’ course outcomes. The accuracy of the models was evaluated based on four-class classification (predicting four possible outcomes) and two-class classification (predicting pass or fail).

Results and Conclusions
The study found that simple indicators, such as a student’s activity level on a given day, could be as effective as more complex data combinations or personal information in predicting student success. The logistic regression model achieved an accuracy of 72.1% for four-class classification and 92.4% for 2-class classification, while the random forest classifier achieved an accuracy of 74.6% for four-class classification and 95.7% for two-class classification. These findings highlight the potential of machine learning models in predicting and understanding students’ course outcomes in MOOCs, offering valuable insights for improving student engagement and success in online learning environments.
Changes of Tamarix austromongolica forests with embankment dams along the Laizhou bay
Authors: Yang Hongxiao , Liu Fangfang , Liu Xinwei , Zhou Zhenfeng , Pan Yanxia , Chu Jianmin 
Published: August 2024

Background
Embankment dams were built south of the Laizhou bay in China for controlling storm surge disasters, but they are not enough to replace coastal forests in protecting the land. This study was designed to evaluate the effects of embankment dams on natural forests dominated by Tamarix austromongolica and test whether the dam-shrub system is a preferable updated defense.

Methods
Coastal forests on two typical flats, one before and one behind embankment dams, were investigated using quadrats and lines. Land bareness, vegetation composition and species co-occurrence were assessed; structures of T. austromongolica populations were evaluated; and spatial patterns of the populations were analyzed using Ripley’s K and K1,2 functions.

Results
In the area before embankment dams, 84.8% of T. austromongolica were juveniles (basal diameter ≤ 3 cm), and 15.2% were adults (basal diameter > 3 cm); behind the dams, 52.9% were juveniles, and 47.1 were adults. In the area before the dams, the land bareness was 13.7%, four species occurred, and they all were ready to co-occur with T. austromongolica; behind the dams, the land bareness was 0%, and 16 species occurred whereas they somewhat resisted co-occurrence with T. austromongolica. In the area before the dams, the T. austromongolica population was aggregated in heterogeneous patches, and the juveniles tended to co-occur with the adults; behind the dams, they were over-dispersed as nearly uniform distributions, while the juveniles could recruit and were primarily independent of the adults. These results indicate that the T. austromongolica species did not suffer from the unnatural dams, but benefited somehow in population expansion and development. Overall, the T. austromongolica species can adapt to artificial embankment dams to create a synthetic defense against storm surges.
Field Efficacy of Biocapsules of Entomopathogenic Fungi for the Management of Aphis craccivora Koch (Homoptera: Aphididae)
Authors: M Parvathi 
Published: August 2024

Many agro-ecosystems have been seriously undermined using synthetic pesticides, and are losing incentive in terms of productivity, with substantial loss of biodiversity. To reclaim ecosystem health and protect global health, there is an important need to put the ecology standards back at the core of crop protection. Biological control methods are favourable alternative methods to the chemical method. In the evaluation of the efficacy of biocapsules of Lecanicillium lecanii (Zimmermann) Zare and Gams and L. saksenae (Kushwaha) Kurihara and Sukarno for the management of cowpea aphid Aphis craccivora Koch (Homoptera: Aphididae), it was revealed that foliar application of L. saksenae and L. lecanii three capsules L-1 sprayed twice (at weekly intervals) were similarly effective in causing 94.38 and 92.28 per cent reduction in the population of A. craccivora and with lower dose at two and one capsules L-1 population noted was 37.51 to 63.96 per cent. The spore suspensions of both fungi were more effective than the lower doses (78.73 - 83.53 per cent reduction) in cowpeas. While Thiamethoxam 25 WG, was 95.79 per cent. Biocapsule treatment did not affect the natural enemy populations significantly. The yield recorded in the plots with L. saksenae capsules at two and three L-1 was higher than other treated and untreated plots. Therefore, the need-based creation of biocontrol formulations in capsules, tablets, powder, etc. should be popularized.
The impact of ozone depleting substances on the circulation, temperature, and salinity of the Southern Ocean: An attribution study with CESM1(WACCM)
Authors: Solomon A. , Polvani L. M. , Smith K. L. , Abernathey R. P. 
Published: June 2015

AbstractObservations show robust changes in the circulation, temperature, and salinity of the Southern Ocean in recent decades. To what extent these changes are related to the formation of the ozone hole in the late twentieth century is an open question. Using a comprehensive chemistry‐climate Earth system model, we contrast model runs with varying and with fixed surface concentrations of ozone depleting substances (ODS) from 1955 to 2005. In our model, ODS cause the majority of the summertime changes in surface wind stress which, in turn, induce a clear poleward shift of the ocean's meridional overturning circulation. In addition, more than 30% of the model changes in the temperature and salinity of the Southern Ocean are caused by ODS. These findings offer unambiguous evidence that increased concentrations of ODS in the late twentieth century are likely to have been been an important driver of changes in the Southern Ocean.
Dynamical downscaling simulation and future projection of precipitation over China
Authors: Bao Jiawei , Feng Jinming , Wang Yongli 
Published: June 2015

AbstractThis study assesses present‐day and future precipitation changes over China by using the Weather Research and Forecasting (WRF) model version 3.5.1. The WRF model was driven by the Geophysical Fluid Dynamics Laboratory Earth System Model with the Generalized Ocean Layer Dynamics component (GFDL‐ESM2G) output over China at the resolution of 30 km for the present day (1976–2005) and near future (2031–2050) under the Representative Concentration Pathways 4.5 (RCP4.5) scenario. The results demonstrate that with improved resolution and better representation of finer‐scale physical process, dynamical downscaling adds value to the regional precipitation simulation. WRF downscaling generally simulates more reliable spatial distributions of total precipitation and extreme precipitation in China with higher spatial pattern correlations and closer magnitude. It is able to successfully eliminate the artificial precipitation maximum area simulated by GFDL‐ESM2G over the west of the Sichuan Basin, along the eastern edge of the Tibetan Plateau in both summer and winter. Besides, the regional annual cycle and frequencies of precipitation intensity are also well depicted by WRF. In the future projections, under the RCP4.5 scenario, both models project that summer precipitation over most parts of China will increase, especially in western and northern China, and that precipitation over some southern regions is projected to decrease. The projected increase of future extreme precipitation makes great contributions to the total precipitation increase. In southern regions, the projected larger extreme precipitation amounts accompanied with fewer extreme precipitation frequencies suggest that future daily extreme precipitation intensity is likely to increase in these regions.
Decadal variability of surface incident solar radiation over China: Observations, satellite retrievals, and reanalyses
Authors: Wang Kaicun , Ma Qian , Li Zhijun , Wang Jiankai 
Published: June 2015

AbstractExisting studies have shown that observed surface incident solar radiation (Rs) over China may have important inhomogeneity issues. This study provides metadata and reference data to homogenize observed Rs, from which the decadal variability of Rs over China can be accurately derived. From 1958 to 1990, diffuse solar radiation (Rsdif) and direct solar radiation (Rsdir) were measured separately, and Rs was calculated as their sum. The pyranometers used to measure Rsdif had a strong sensitivity drift problem, which introduced a spurious decreasing trend into the observed Rsdif and Rs data, whereas the observed Rsdir did not suffer from this sensitivity drift problem. From 1990 to 1993, instruments and measurement methods were replaced and measuring stations were restructured in China, which introduced an abrupt increase in the observed Rs. Intercomparisons between observation‐based and model‐based Rs performed in this research show that sunshine duration (SunDu)‐derived Rs is of high quality and can be used as reference data to homogenize observed Rs data. The homogenized and adjusted data of observed Rs combines the advantages of observed Rs in quantifying hourly to monthly variability and SunDu‐derived Rs in depicting decadal variability and trend. Rs averaged over 105 stations in China decreased at −2.9 W m−2 per decade from 1961 to 1990 and remained stable afterward. This decadal variability is confirmed by the observed Rsdir and diurnal temperature ranges, and can be reproduced by high‐quality Earth System Models. However, neither satellite retrievals nor reanalyses can accurately reproduce such decadal variability over China.
The relationship between environmental change and the extinction of the nannoplankton Discoaster in the early Pleistocene
Authors: Schueth Jonathan D. , Bralower Timothy J. 
Published: June 2015

AbstractThe long‐ranging nannoplankton genus Discoaster went extinct in the early Pleistocene, one of the most significant events in the Cenozoic nannofossil record. The causal factors of this extinction are poorly constrained, at least partially because the ecology of Discoaster is not well understood. We investigate the relationship between the extinction and environmental changes by comparing a suite of high‐resolution nannofossil assemblage data at four Ocean Drilling Program sites to published environmental proxy records. Through the use of multivariate analysis, we determine Discoaster shared environmental preferences with the extant species Florisphaera profunda which thrives in the lower photic zone near the nutricline in locations where the water column is stratified. We show that the last occurrence of Discoaster was globally diachronous, rather than synchronous as previously thought, and likely took place in the equatorial Atlantic Ocean. We propose that the demise of Discoaster was a two‐stage process. A decrease in sea surface temperatures and increase in climate variability led to a global decline in Discoaster abundance. The extinction event itself correlates to shoaling of the nutricline as signified by a decrease in the carbon isotopic gradient between surface and thermocline foraminifera. We hypothesize that the combination of global cooling and a shoaling of the nutricline greatly reduced Discoaster's deepwater niche and contributed to its extinction. This may suggest that ocean stratification and the depth of the nutricline are important contributors to overall nannoplankton diversity.
Early cytotoxic lymphocyte expansion contributes to a deep molecular response to dasatinib in patients with newly diagnosed chronic myeloid leukemia in the chronic phase: results of the D‐first study
Authors: Iriyama Noriyoshi , Fujisawa Shin , Yoshida Chikashi , Wakita Hisashi , Chiba Shigeru , Okamoto Shinichiro , Kawakami Kimihiro , Takezako Naoki , Kumagai Takashi , Inokuchi Koiti , Ohyashiki Kazuma , Taguchi Jun , Yano Shingo , Igarashi Tadahiko , Kouzai Yasuji , Morita Satoshi , Sakamoto Junichi , Sakamaki Hisashi 
Published: June 2015

Dasatinib is one of the key treatment options for chronic myeloid leukemia (CML) patients. Increase in lymphocyte counts has been known to be predictive of a good treatment response under dasatinib treatment as a second line therapy. However, clinical significance of lymphocyte dynamics in the upfront setting has yet to be clarified. To investigate the significance of lymphocyte dynamics in newly diagnosed chronic phase (CP)‐CML, patient data of D‐First study (ClinicalTrials.gov NCT01464411) were analyzed. Fifty‐two CML‐CP patients enrolled to this study were treated with dasatinib (100 mg day−1) and all were followed‐up for 18 months. The incidence of lymphocyosis was observed in 14 (27%), but it was not associated with deep molecular response achievement. However, natural killer (NK) cell or cytotoxic T lymphocyte (CTL) counts at 1 month were significantly higher in patients with deep molecular response (DMR) by 18 months compared to those without DMR. When the patients were divided into two groups according to those calculated thresholds by receiver operating characteristic curve (407/μL for NK cells and 347/μL for CTLs), the cumulative DMR rates by 18 months were significantly better in higher value group compared to lower value group. In contrast, regulatory T cell counts were significantly lower at 12 and 15 months in patients achieved DMR. These results suggest the presence of dual effects of dasatinib on immune system through the cytotoxic lymphocytes activation and Treg deregulation in different periods in newly diagnosed CML‐CP. Am. J. Hematol. 90:819–824, 2015. © 2015 Wiley Periodicals, Inc.
Selective Synthesis of Acenaphtho[1,2‐b]indole Derivatives via Tandem Regioselective Aza‐Ene Addition/N‐Cyclization/SN1 Type Reaction
Authors: Chen Xue‐Bing , Luo Ting‐Bi , Gou Gao‐Zhang , Wang Jing , Liu Wei , Lin Jun 
Published: June 2015

AbstractA concise and efficient synthesis of acenaphtho[1,2‐b]indoles with different substitution patterns from a [3+2] condensation of enaminones with acenaphthoquinone has been developed. During the first pathway, products 3 were synthesized in the presence of Et3N, while a second reaction in the presence of p‐toluenesulfonic acid leads to compounds 5 via intramolecular cyclization and highly regioselective SN1‐type reaction with alcohols under solvent‐free conditions. Both procedures give excellent yields and are highly eco‐benign, are convenient one‐pot operations, are highly regioselectivity, and use environmentally friendly solvent systems or operate under solvent‐free conditions. This method offers an alternative to regioselective construction of biologically meaningful polycyclic indoles.