bluuebunny/crossref_metadata_2025_split huggingface dataset:
tert‐Butylcarbamate‐Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells
Authors: Valente Sergio , Trisciuoglio Daniela , Tardugno Maria , Benedetti Rosaria , Labella Donatella , Secci Daniela , Mercurio Ciro , Boggio Roberto , Tomassi Stefano , Di Maro Salvatore , Novellino Ettore , Altucci Lucia , Del Bufalo Donatella , Mai Antonello , Cosconati Sandro 
Published: March 2013

AbstractHerein we report novel pyrrole‐ and benzene‐based hydroxamates (8, 10) and 2′‐aminoanilides (9, 11) bearing the tert‐butylcarbamate group at the CAP moiety as histone deacetylase (HDAC) inhibitors. Compounds 8 b and 10 c selectively inhibited HDAC6 at the nanomolar level, whereas the other hydroxamates effected an increase in acetyl‐α‐tubulin levels in human acute myeloid leukemia U937 cells. In the same cell line, compounds 8 b and 10 c elicited 18.4 and 21.4 % apoptosis, respectively (SAHA: 16.9 %), and the pyrrole anilide 9 c displayed the highest cytodifferentiating effect (90.9 %). In tests against a wide range of various cancer cell lines to determine its antiproliferative effects, compound 10 c exhibited growth inhibition from sub‐micromolar (neuroblastoma LAN‐5 and SH‐SY5Y cells, chronic myeloid leukemia K562 cells) to low‐micromolar (lung H1299 and A549, colon HCT116 and HT29 cancer cells) concentrations. In HT29 cells, 10 c increased histone H3 acetylation, and decreased the colony‐forming potential of the cancer cells by up to 60 %.
Tomographic Reconstruction of Designer Free‐Electron Wave Packets
Authors: Wollenhaupt Matthias , Lux Christian , Krug Marc , Baumert Thomas 
Published: March 2013

AbstractWe review the generation and tomographic reconstruction of designer electron wave packets, that is, electron wave packets with a tailored momentum distribution in the continuum. Generation is accomplished by means of multiphoton ionization of an atomic prototype using polarization‐shaped femtosecond laser pulses. Both the electronic structure of the neutral and interference of matter wave packets in the continuum contribute to the final shape. For the measurement of the resulting three‐dimensional photoelectron angular distributions (3dPAD) we combine the established technique of velocity map imaging (VMI) with a tomographic reconstruction method. This novel experimental approach can be employed to characterize the 3dPAD in the laboratory frame as well as in the molecular frame of larger molecules. Due to its sensitivity to electronic structure this method can be further developed to highly sensitive analytic techniques in the gas phase, for instance for the identification of chiral molecules.
Molecular Suction Pads: Self‐Assembled Monolayers of Subphthalocyaninatoboron Complexes on Gold
Authors: Glebe Ulrich , Baio Joe E. , Árnadóttir Líney , Siemeling Ulrich , Weidner Tobias 
Published: March 2013

AbstractSubphthalocyaninatoboron complexes with six long‐chain alkylthio substituents in their periphery are applicable for the formation of self‐assembled monolayers (SAMs) on gold. Such films are prepared from solution with the axially chlorido‐substituted derivatives and characterised by near‐edge X‐ray absorption fine structure (NEXAFS) spectroscopy, X‐ray photoelectron spectroscopy (XPS) and time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). The results are in accord with the formation of SAMs assembled by the chemisorption of both covalently bound thiolate‐type as well as coordinatively bound thioether units. The adsorbate molecules adopt an essentially flat adsorption geometry on the substrate, resembling a suction pad on a surface.
The Protective Role of Self‐compassion in Relation to Psychopathology Symptoms and Quality of Life in Chronic and in Cancer Patients
Authors: Pinto‐Gouveia José , Duarte Cristiana , Matos Marcela , Fráguas Sofia 
Published: March 2013

The importance of self‐compassion in the context of medical problems has been highlighted in previous research. Its role in the psychological adjustment of cancer patients, however, has remained unexplored. The current study aimed at examining whether self‐compassion and self‐critical judgement would distinctively predict general psychopathological symptoms and quality of life in three distinct groups: a mixed sample of cancer patients (n = 63), patients with chronic illnesses (n = 68) and healthy subjects (n = 71).Correlation analyses revealed significant associations between lower self‐compassion and increased depressive and stress symptoms, and lower scores in quality of life dimensions in the patients' samples. The opposite correlational pattern was found regarding self‐critical judgement. In the case of healthy subjects, these correlations were weaker or nonsignificant. Regression analyses revealed that in patients with chronic illnesses, self‐critical judgement emerged as the best predictor of depressive and stress symptoms, and quality of life dimensions. In patients with cancer, however, it was the affiliate dimension of self‐compassion that was found to significantly predict lower levels of depressive and stress symptoms, and increased quality of life.These findings have important clinical implications by suggesting the relevance of nurturing a caring and kind relation with oneself in the face of challenging medical conditions, particularly in patients with cancer. Copyright © 2013 John Wiley & Sons, Ltd.Key Practitioner Message

The link between self‐compassion and psychopathology and quality of life was examined in a mixed sample of cancer patients, in chronic patients, and in healthy subjects.
Self‐compassion is associated with decreased psychopathological symptoms of stress and depression, and better quality of life in patients with chronic illnesses, and especially in patients with cancer.
Psychological supportive interventions targeting the development of self‐compassionate attributes and skills may have beneficial effects in the psychological adjustment of medically ill patients, namely patients with cancer.
Efficient inhibition of human leukocytic elastase by means of α1‐antitrypsin/peptide complexes
Authors: Leßig Jacqueline , Reibetanz Uta , Schönberg Maria , Neundorf Ines 
Published: March 2013

Abstractα1‐Antitrypsin (AT), a serine protease inhibitor that specifically targets hydrolytic enzymes, plays a significant role in the termination of tissue inflammation and can therefore represent a key factor in chronic incidences as chronic obstructive pulmonary disease (COPD) or chronic hepatitis. A local and low‐dose therapy for the treatment of acquired chronic inflammatory processes which are characterized by insufficient AT amounts but also of genetically conditioned AT deficiencies is supposed to be more effective and less cost‐intensive compared to current therapies. In this study, a noncovalent complex formation between the cell‐penetrating peptide carrier hCT(18‐32)‐k7 and AT was performed. The complex was applied to HEK293T/17 cells, as proof‐of‐principle, and polymorphonuclear leukocytes (PMN), which are responsible for tissue destruction and the perpetuation of inflammation in chronic processes. Both cell species show a successful uptake and subsequently both, an intracellular dot‐shaped and homogeneous distribution of the complex demonstrating phagolysosomal as well as cytoplasmic availability. Furthermore, a decreased human leukocytic elastase (HLE) activity was observed after the direct complex administration to PMN. Since the application did not cause an enhanced vitality loss, the complex could facilitate an improvement in direct, local and low‐dose treatment of chronically proceeding processes in order to attenuate protease‐mediated tissue destruction. © 2013 International Society for Advancement of Cytometry
Synthesis and Pharmacological Evaluation of 6‐Arylpyridazinones as Potent Vasorelaxants
Authors: Bansal Ranju , Kumar Dinesh , Sharma Deepika , Calle Carmen , Carron Rosalia 
Published: March 2013

Abstract

Preclinical Research

As part of a research program to identify compounds with potent antihypertensive properties, a new series of dihydropyridazin‐3(2H)‐one analogs was synthesized and evaluated for vasodilator activity in rat thoracic aortic rings. Most of the newly synthesized compounds displayed good vasorelaxant activity as compared with SK&F‐93741 and hydralazine, with the N2‐unsubstituted 4‐isobutyramidophenylpyridazinone derivative 5 being the most potent vasorelaxant, producing vasorelaxation greater than that of hydralazine and equipotent to SK&F‐93741. A significant effect of the 6‐phenyl substituents and substitution at N‐2 position of pyridazinone nucleus on the vasodilatory activity was observed.
Check dam influence on vegetation species diversity in mountain torrents of the Mediterranean environment
Authors: Bombino Giuseppe , Boix‐Fayos Carolina , Gurnell Angela M. , Tamburino Vincenzo , Zema Demetrio Antonio , Zimbone Santo Marcello 
Published: March 2013

ABSTRACTPrevious research has developed a method to assess the impact of check dams on riparian vegetation and related river bed sediment size with vegetation coverage and development. On the basis of this knowledge, this paper aims to investigate the effects on riparian species diversity induced by 32 check dams in four torrent headwaters of Southern Italy. Species richness and composition of riparian vegetation in the active channel were surveyed upstream and downstream of each check dam and in intermediate (less disturbed) sites. Furthermore, links between hydromorphological processes and vegetation diversity were analysed.The identified differences in species diversity seem to be related to the morphological adjustments of the channel after the installation of check dams. These fluvial morphological adjustments introduced variations to the flood depth and frequency of the riparian areas creating new riparian conditions. Higher species richness and evenness were observed upstream of check dams, where alien species prevail over native ones in new habitats on the sedimentation wedge behind the dam. Conversely, downstream of check dams, where the boundary of the inundated area moves down towards the thalweg (due to incision processes after check dam installation), riparian vegetation tends to assume a terrestrial character, losing some herbaceous species of the riparian environment.This research confirms that the discontinuity in the fluvial environment caused by check dams induces morphological adjustments that can be translated in new riparian conditions for the establishment of vegetation, affecting the ecological aspects and species diversity of riparian habitats. Copyright © 2013 John Wiley & Sons, Ltd.
Can Substitution of Chlorides Enhance the Cytotoxicity of Vanadocene Dichloride?
Authors: Vinklárek Jaromír , Hurychová Hana , Honzíček Jan , Šebestová Lucie , Padělková Zdeňka , Řezáčová Martina 
Published: March 2013

AbstractA series of vanadocene complexes [Cp′2V(L)][OTf]2 (Cp′ = η5‐C5H5, η5‐C5H4Me; L = phen, 5‐NO2‐phen, 5‐NH2‐phen, 4,7‐Ph2‐phen) was prepared and characterized by mass spectrometry and EPR spectroscopy. Structures of two complexes that contain an N,N′‐chelating ligand, [(η5‐C5H4Me)2V(phen)][OTf]2·0.5Me2CO and [(η5‐C5H5)2V(5‐NH2‐phen)][OTf]2, and the triflate intermediate [(η5‐C5H5)2V(OTf)2] were further confirmed by X‐ray diffraction analysis. The cytotoxicity study has shown that complexes that contain phenanthroline ligands have considerably higher in vitro activity toward human leukemia cells MOLT‐4 and HL‐60 than their parent dichlorides ([Cp′2VCl2]). The high activity of these complexes coheres with their higher stability in various aqueous media. This study has further shown that substitution of chloride ligands in the vanadocene dichloride has a considerably higher effect on cytotoxicity than expected on the basis of established mechanistic rules.
Examining the Draw of Diversity: How Diversity Climate Perceptions Affect Job‐Pursuit Intentions
Authors: Avery Derek R. , Volpone Sabrina D. , Stewart Robert W. , Luksyte Aleksandra , Hernandez Morela , McKay Patrick F. , Hebl Michelle (Mikki) R. 
Published: March 2013

AbstractOrganizations must target talented applicants, who will often be demographically diverse, to attract the most competent and competitive workforce possible. Despite the bottom‐line implications of attracting the best and brightest, surprisingly little is known about how and why diversity recruitment strategies affect recruitment outcomes (e.g., job‐pursuit intentions). To gain insight into this question, we conducted an initial experimental study (N = 194) to test the premise that other‐group orientation moderates the relationship between perceived organizational value of diversity and job‐pursuit intentions. In a follow‐up experiment (N = 255), identity affirmation was examined as the mediating mechanism for the interaction observed in the first study. Mediated moderation analyses supported the proposed model. Collectively, the studies indicate that job seekers high in other‐group orientation are more intent on pursuing employment with organizations deemed to value diversity because they feel that their salient identities are likely to be affirmed. No such indirect effect is present for those lower in other‐group orientation.
Inducing Employees to Leave: A Comparison of Four Severance Options
Authors: Strandholm Karen , Schatzel Kim , Callahan Thomas 
Published: March 2013

AbstractThis study examines the demographic, economic, and psychographic characteristics of 324 blue‐collar workers who were offered four options for either retirement or severance from the organization. Consistent with previous research, individuals who accepted retirement options have more organizational tenure and believed that the packages would provide stable financial futures. A key finding for those who accepted the nonretirement options is that comparable employment would be available. The study concludes with research limitations and suggestions for future research.
The Link Between Diversity and Equality Management Practice Bundles and Racial Diversity in the Managerial Ranks: Does Firm Size Matter?
Authors: Richard Orlando C. , Roh Hyuntak , Pieper Jenna R. 
Published: March 2013

AbstractInvoking strategic human resource management (SHRM) theory and tenets of the resource‐based view of the firm, we explore how two bundles of diversity and equality management (DEM) practices influence racial diversity in the managerial ranks. By considering the conceptualization of DEM practices and the moderating role of firm size, our study disentangles subtle nuances in the DEM practices–racial diversity in managerial ranks relationship. Based on a sample of 137 Fortune 1,000 firms over a two‐year period, our results suggest that minority opportunity‐based DEM practices and manager accountability DEM practices positively relate to racial diversity in managerial ranks, and these relationships are stronger in smaller companies than large ones. Theoretical and practical implications for a strategic perspective on future diversity management research are elaborated.
Skeletal clinical characteristics of osteogenesis imperfecta caused by haploinsufficiency mutations in COL1A1
Authors: Ben Amor I Mouna , Roughley Peter , Glorieux Francis H , Rauch Frank 
Published: March 2013

ABSTRACT

COL1A1 haploinsufficiency mutations lead to the mildest form of osteogenesis imperfecta (OI), OI type I. The skeletal clinical characteristics resulting from such mutations have not been characterized in detail. In this study we assessed 86 patients (36 male, 50 female; mean age 13.3 years; range, 0.6 to 54 years) with COL1A1 haploinsufficiency mutations, of whom 70 were aged 21 years or less (“pediatric” patients). Birth history was positive for fracture or long-bone deformity in 12% of patients. The average rate of long-bone fracture (femur, tibia/fibula, humerus, radius/ulna) in pediatric patients was 0.62 fractures per year, one-half of which affected the tibia/fibula. Long-bone fracture rate was negatively associated with age and lumbar spine areal bone mineral density. Vertebral compression fractures were observed in 71% of the 58 pediatric patients who had lateral spine radiographs. The median number of vertebral fractures was higher for females (median 4; range, 0 to 14) than for males (median 1; range, 0 to 8) (p = 0.03). Lumbar spine areal bone mineral density was negatively associated with the severity of vertebral compression fractures, as reflected in the spine deformity index. Scoliosis was present in about 30% of pediatric patients but the Cobb angle was &lt;30 degrees in all cases. The average final height Z-score was –1.1, representing a deficit of 8 to 10 cm compared to the general population. In summary, OI patients with COL1A1 haploinsufficiency mutations have high rates of significant skeletal involvement. Systematic follow-up of growing patients with COL1A1 haploinsufficiency mutations including radiographic screening for vertebral compression fractures and scoliosis is warranted.
Salivary Cortisol Lower in Posttraumatic Stress Disorder
Authors: Wahbeh Helané , Oken Barry S. 
Published: March 2013

Altered cortisol has been demonstrated to be lower in those with posttraumatic stress disorder (PTSD) in most studies. This cross‐sectional study evaluated salivary cortisol at waking and 30 minutes after, and at bedtime in 51 combat veterans with PTSD compared to 20 veterans without PTSD. It also examined the relationship of cortisol to PTSD symptoms using 2 classifications: the Diagnostic and Statistical Manual of Mental Disorders (4th ed., DSM‐IV; American Psychiatric Association, 1994) and the more recent 4‐factor classification proposed for DSM‐5. The PTSD group had lower cortisol values than the control group, F(6, 69) = 3.35, p = .006. This significance did not change when adding age, body mass index, smoking, medications affecting cortisol, awakening time, sleep duration, season, depression, perceived stress, service era, combat exposure, and lifetime trauma to the model. Post hoc analyses revealed that the PTSD group had lower area‐under‐the‐curve ground and waking, 30 min, and bedtime values; the cortisol awakening response and area‐under‐the‐curve increase were not different between groups. The 4‐factor avoidance PTSD symptom cluster was associated with cortisol, but not the other symptom clusters. This study supports the finding that cortisol is lower in people with PTSD.
Determinants of bilateral audiometric notches in noise‐induced hearing loss
Authors: Hsu Tun‐Yen , Wu Chen‐Chi , Chang Jan‐Gowth , Lee Shiann‐Yann , Hsu Chuan‐Jen 
Published: March 2013

AbstractObjectives/Hypothesis:To explore the possible determinants of bilateral audiometric notches in noise‐induced hearing loss (NIHL).Study Design:Prospectively enrolled cohort with cross‐sectional analysis.Methods:Male workers (n = 412) with exposure to continuous loud noise (noise exposure level normalized to a nominal 8‐hour working day >75 dBA) during work were included in this cohort study. The relationship between the presence of bilateral audiometric notches and age, noise exposure duration, noise exposure level, and shift from the predicted thresholds over different frequencies were determined by regression model analysis, receiver operating characteristic analysis, and area under the curve analysis.Results:The presence of bilateral audiometric notches was closely associated with the shifts from the predicted thresholds over 1, 2, 3, 4, and 6 kHz. The shift pattern was somewhat different between those who used hearing protection devices and those who did not. The shifts from the predicted thresholds demonstrated a stronger association with bilateral audiometric notches than did age, gender, noise exposure level, or noise exposure duration.Conclusions:The bilateral audiometric notches in NIHL could not be determined only on the basis of age, gender, noise exposure level, or noise exposure duration. The importance of other factors associated with bilateral audiometric notches should be recognized. Elucidation of the factors of formation of bilateral audiometric notches would help us to develop a more comprehensive protection strategy to prevent further NIHL.
Real‐time measurement of electrode impedance during intracochlear electrode insertion
Authors: Tan Chin‐Tuan , Svirsky Mario , Anwar Abbas , Kumar Shaun , Caessens Bernie , Carter Paul , Treaba Claudiu , Roland J. Thomas 
Published: March 2013

AbstractObjectives/Hypothesis:This pilot study details the use of a software tool that uses continuous impedance measurement during electrode insertion, with the eventual potential to assess and optimize electrode position and reduce insertional trauma.Study Design:Software development and experimental study with human cadaveric cochleae and two live surgeries.Methods:A prototype program to measure intracochlear electrode impedance and display it graphically in real time has been developed. The software was evaluated in human cadaveric temporal bones while simultaneously making real‐time fluoroscopic recordings and in two live surgeries during intracochlear electrode insertion.Results:Impedance changes were observed with various scalar positions, and values were consistent with those obtained using clinically available software. Using Contour Advance electrodes, impedance values increased after stylet removal, particularly when using the monopolar mode.Conclusions:Impedance values seem systematically affected by electrode position, with higher values being associated with proximity to the cochlear wall. The new software is capable of acquiring impedance measurements during electrode insertion, and these data may be useful to guide surgeons to achieve optimal and atraumatic electrode insertion, to guide robotic electrode insertion, and to provide insights about electrode position in the cochlea.
Quantifying the effects of altering ambient humidity on ionic composition of vocal fold surface fluid
Authors: Sivasankar M. Preeti , Carroll Thomas L. , Kosinski Aaron M. , Rosen Clark A. 
Published: March 2013

Objectives/HypothesisVocal fold surface fluid (VFSF) is important in hydration and defense of underlying epithelial cells. The objective of this study was to quantify changes in the ionic composition of VFSF after altering the humidity of inhaled air. We tested the hypothesis that low humidity exposure would increase the concentration of VFSF sodium (Na+) and chloride (Cl−) ions but that high humidity exposure would decrease the concentration of VFSF Na+ and Cl− ions as compared to the low humidity challenge.Study DesignProspective design.MethodsEighteen healthy adults participated in this study. VFSF was collected from each subject at baseline and following exposure to low humidity and high humidity environments. VFSF Na+ concentration was assessed using inductively coupled plasma mass spectrometry. VFSF Cl− concentration was measured with indirect potentiometry. All analyses were completed by personnel blinded to the hypothesis being tested.ResultsThe low humidity environment increased Na+ concentration in the majority of the subjects. Data for changes in Cl− concentrations were variable. Overall the data did not reach statistical significance (P > .05). Subjective impressions suggested that VFSF collection was more difficult in low humidity as compared to the high humidity and baseline conditions.ConclusionsThis study is the first attempt to measure the ionic concentration of VFSF. The results from the current study have important implications for future programmatic research quantifying the effects of pollutants and laryngopharyngeal reflux on VFSF composition, epithelial hydration, and vocal fold defense.