bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombolysis with tenecteplase in acute ischaemic stroke in a tertiary care setting in Sri Lanka: A retrospective study
Authors: Gooneratne Kishara , Vithanage Lakmal , Talagala Ishanka , Lokunarangoda Niroshan C. , Gamage Nilantha , Muthumala Nishantha P. , Rodrigo Aruna , Kosgahakumbura Jagath , Liyanage Gimhani , Perera Amandi , Ranawaka Udaya K. 
Published: August 2024

Introduction: Alteplase (ALT) is the standard thrombolytic treatment in acute ischaemic stroke (AIS). Tenecteplase (TNK) is proven to be effective in acute coronary syndrome, is relatively cheap, widely available and can easily be given as a single intravenous (IV) bolus. Despite evidence for its use, there is equivocal guidance for the use of TNK in AIS. On the background of a global reduction in stroke admissions, treatment interventions and prolonged treatment time metrics due to the COVID-19 pandemic, this study highlights the experience with TNK in a tertiary care setting in Sri Lanka, during the pandemic.Objectives: To describe the outcomes at 48 hours among stroke patients who underwent thrombolysis with TNK at District General Hospital Hambantota, Sri Lanka over a period of one year.Methods: We retrospectively reviewed records of adults with AIS thrombolysed with 0.25 mg/kg TNK. The National Institutes of Health Stroke Scale (NIHSS) was assessed on admission and at 24-hours following treatment. Patients were observed for 48-hours for potential adverse events.Results: We thrombolysed 20 consecutive patients over one-year. The baseline mean NIHSS was 9.7 (standard deviation (SD)=4.4; range 4-22), and the 24h-post thrombolysis mean NIHSS was 6.0 (SD=7.3; range 0-28). Seventy percent (n=14) showed an improved NIHSS of at least 1-point after thrombolysis (mean difference=3.7; SD=6.46), and 55%(n=11) displayed a major clinical improvement (change in NIHSS ≥ 4). Ten percent (n=2) developed major adverse effects (one intra-cranial haemorrhage; one haemorrhagic transformation). There were no deaths.Conclusions: TNK 0.25mg/kg for the treatment of AIS appeared efficacious and safe in our case series. The limitation in this study was the low number of patients who underwent thrombolysis during the study period, as a probable effect of the COVID-19 pandemic. Thrombolysis with TNK could be a cost-effective alternative to alteplase in resource-limited South Asian settings.
Frequency of depression and its correlation with sociodemographic and clinical characteristics among adult epilepsy patients in neurology clinics at a tertiary care hospital in Sri Lanka
Authors: Ratnayake Gimhani , Dissanayake Athula , Liyanage Damith , Sumanasekara Wasana , Sivanesan Pratheepa 
Published: August 2024

Background: Depression is a common concern among epilepsy patients and affects individuals globally. This presents substantial clinical, social, and economic ramifications, impacting healthcare requirements, quality of life, and productivity. Despite this, comprehensive data on depression in epilepsy remain scarce for Asia, with no published studies from Sri Lanka.Objective: This study aimed to determine the frequency of depression, and its associated sociodemographic and clinical characteristics, among adult epilepsy patients in a tertiary care hospital in Sri Lanka.Method: A descriptive cross-sectional study was performed at teaching hospital Karapitiya, involving 413 epilepsy patients. Exclusion criteria included individuals under 18 years, presence of other neurological conditions, chronic severe medical ailments, additional psychiatric comorbidities, history of active cancer within the last five years, and current illicit drug use. Consecutive sampling was employed. Data collection utilized an interviewer-administered sociodemographic and clinical characteristics questionnaire, alongside the 9-item Patient Health Questionnaire (PHQ-9). Statistical analysis was performed using SPSS software.Results: The observed frequency of depression among epilepsy patients attending the clinic was 29.8%. Among those affected, 21.3% exhibited mild depression, 5.6% moderate depression, 2.2% moderately severe depression, and 0.7% reported severe depression. The statistically significant associations with depression among epilepsy patients included recent seizure occurrence (p=0.001), marital status (p=0.009), and parenthood status (p=0.011).Conclusions: The observed frequency of depression among the study population surpassed that in the general Sri Lankan populace (4.1%). Timely identification and management of psychiatric comorbidities linked to epilepsy hold promise for optimising healthcare resource allocation in Sri Lanka.
Medical student learning on a distributed training platform in rural district hospitals
Authors: Ross Andrew J. , Nkabinde Thandaza C. , Gaede Bernhard 
Published: August 2024

Background: Decentralising medical school training enhances curriculum relevance, exposing students to generalist patient care in diverse contexts.Aim: The aim of the study was to understand the student experiences of learning during their 7-week Family Medicine rural rotation.Setting: Final year medical students who had completed their Family Medicine rotation in November 2022.Methods: A qualitative study involving 24 final year students (four semi- structured interviews and four focus group discussions [4 x 5 students]). All interviews were recorded, transcribed verbatim and analysed thematically.Results: Analysis revealed positive learning experiences and identified the following themes: taking responsibility for learning, the generalist context, teaching and learning in context and managing the learning environment.Conclusion: Active participation in hospital activities, exposure to disorientating dilemmas that challenged assumptions and reflection on these experiences led to transformative learning and knowledge co-construction.Contribution: The study contributes to the discussion and reinforces the advantages of distributed, experiential training, highlighting the positive impact of meaningful participation and transformative learning opportunities.
Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure: Systematic review and meta-analysis
Authors: Safwan Moaz , Bourgleh Mariam Safwan , Aldoush Mohamed , Haider Khawaja Husnain 
Published: August 2024

BACKGROUND
Mesenchymal stem cells (MSCs), as living biodrugs, have entered advanced phases of clinical assessment for cardiac function restoration in patients with myocardial infarction and heart failure. While MSCs are available from diverse tissue sources, bone-marrow-derived MSCs (BM-MSCs) remain the most well-studied cell type, besides umbilical-cord-derived MSCs (UC-MSCs). The latter offers advantages, including noninvasive availability without ethical considerations.
AIM
To compare the safety and efficacy of BM-MSCs and UC-MSCs in terms of left ventricular ejection fraction (LVEF), 6-min walking distance (6MWD), and major adverse cardiac events (MACEs).
METHODS
Five databases were systematically searched to identify randomized controlled trials (RCTs). Thirteen RCTs (693 patients) were included using predefined eligibility criteria. Weighted mean differences and odds ratio (OR) for the changes in the estimated treatment effects.
RESULTS
UC-MSCs significantly improved LVEF vs controls by 5.08% [95% confidence interval (CI): 2.20%-7.95%] at 6 mo and 2.78% (95%CI: 0.86%-4.70%) at 12 mo. However, no significant effect was observed for BM-MSCs vs controls. No significant changes were observed in the 6MWD with either of the two cell types. Also, no differences were observed for MACEs, except rehospitalization rates, which were lower only with BM-MSCs (odds ratio 0.48, 95%CI: 0.24-0.97) vs controls.
CONCLUSION
UC-MSCs significantly improved LVEF compared with BM-MSCs. Their advantageous characteristics position them as a promising alternative to MSC-based therapy.
Resepsi Organisasi Masyarakat Nahdlatul Ulama dan Wahdah Islamiyah terhadap Cadar di Kabupaten Majene
Authors: Octaviani Nur Afni , Nasir Muhammad Nasir , Yunan Muhammad 
Published: August 2024

Controversial debate surrounding the veil and its prohibition in several institutions in Indonesia. Employing a qualitative approach and a descriptive comparative method, primary data is obtained from the organizations' officials, while secondary data involves relevant literature. Data collection methods include observation, interviews, and documentation, with analysis using Hans Robert Jauss' reception theory. Nahdlatul Ulama sees the veil not as an obligation in Islam but as a pre-Islamic tradition. They emphasize the importance of covering the aurat according to specified conditions, irrespective of the model of aurat covering. Conversely, Wahdah Islamiyah considers the veil a duty and recommendation to preserve the honor of Muslim women. The research findings indicate that Nahdlatul Ulama is oriented towards the Quran, hadith, fiqh books, ijma, and qiyas, following the Shafi'i school, while Wahdah Islamiyah relies on the Hambali school and classical interpretations of related verses. Both organizations agree that the essence of wearing the veil lies in the purity of the heart and choosing clothing in accordance with religious norms.

Penelitian ini mengevaluasi pandangan Nahdlatul Ulama dan Wahdah Islamiyah terhadap cadar di Majene menggunakan metode Living Qur'an. Fokusnya pada perdebatan kontroversial seputar cadar dan pelarangan di beberapa instansi di Indonesia. Dengan pendekatan kualitatif dan metode deskriptif komparatif, data primer diperoleh dari pengurus ormas, sedangkan data sekunder melibatkan literatur terkait. Metode pengumpulan data melibatkan observasi, wawancara, dan dokumentasi, dengan analisis menggunakan teori resepsi Hans Robert Jauss. Nahdlatul Ulama melihat cadar bukan kewajiban Islam, melainkan tradisi pra-Islam. Mereka menekankan pentingnya menutup aurat sesuai syarat, tanpa memandang model penutup aurat. Wahdah Islamiyah, sebaliknya, menganggap cadar sebagai kewajiban dan anjuran untuk menjaga kehormatan wanita Muslim. Hasil penelitian menunjukkan Nahdlatul Ulama berorientasi pada al-Qur'an, hadis, kitab fiqih, ijma, dan qiyas, mengikuti mazhab Imam Syafi'i, sementara Wahdah Islamiyah berlandaskan pada mazhab Hambali. Keduanya sepakat bahwa inti penggunaan cadar adalah kebersihan hati dan pemilihan pakaian sesuai norma agama.
MEDIASI YUDISIAL KE DALAM SISTEM PERADILAN PERDATA DI INDONESIA
Authors: Adnantara Kadek Prediandrika 
Published: August 2024

Judicial mediation is an alternative method of dispute resolution that has been growing rapidly lately. Judicial mediation assigning judges as mediators has many advantages. The success of this mediation is expected to ease the task of the judge because with this mediation it means that the parties to the dispute have contributed to the implementation of the principle of fast, simple and low-cost justice. As for the background of the problem, how effective is the judicial mediation itself in the civil justice system and what are the obstacles during judicial mediation in civil courts. The purpose of writing this thesis is to find out the effectiveness of Judicial Mediation and the obstacles that occur in Civil Courts. 1 of 2002 concerning the Empowerment of Courts of First Instance to Implement Peaceful Institutions. Supreme Court Regulation (PERMA) Number 2 of 2003 concerning Mediation Procedures in Courts. PERMA Number 1 of 2008 concerning Mediation Procedures in Courts. PERMA Number 1 of 2016 concerning mediation procedures in court. The results of the study concluded that the effectiveness of the implementation of Judicial Mediation in Civil Courts is ineffective because of the small peace agreement in the implementation of mediation. This can be seen from the obstacles in reaching a peace agreement in the Judicial Mediation process in Civil Courts which are still low due to the fact that first the parties do not have good faith in mediation, the two mediator judges in court are still few, third the number of impartial advocates or lawyers to reconcile .
PENGARUH KNOWLEDGE SHARING DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN PADA SWARI SPA RELAXATION, BADUNG, BALI
Authors: Purnawati Ni Luh Gede Putu , Yudiastra Putu Pande , Ribek Pande Ketut 
Published: August 2024

Seiring dengan kemajuan ilmu pengetahuan dan teknologi, setiap perusahaan dituntut agar melakukan inovasi secara berkelanjutan serta memiliki sumber daya manusia dengan tingkat kinerja yang tinggi, sehingga dapat memiliki daya saing yang tinggi terhadap perusahaan lainnya. Hal tersebut juga berlaku kepada Swari Spa Relaxation. Penelitian ini bertujuan untuk menganalisis pengaruh knowledge sharing dan lingkungan kerja terhadap kinerja karyawan di Swari Spa Relaxation, Badung. Jumlah sampel yang digunakan pada penelitian ini sebanyak 46 orang dengan menggunakan metode sampel jenuh. Pengumpulan data menggunakan kuesioner. Teknik analisa data menggunakan analisis regresi linear berganda. Uji hipotesis menggunakan uji f dan uji t. Hasil penelitian menunjukkan bahwa knowledge sharing, berpengaruh positif dan signifikan terhadap kinerja karyawan di Swari Spa Relaxation, Badung. Lingkungan kerja berpengaruh positif dan signifikan terhadap kinerja karyawan di Swari Spa Relaxation, Badung. Adapun keterbatasan dalam penelitian ini yaitu penelitian ini hanya berfokus terhadap 2 variabel yaitu knowledge sharing dan lingkungan kerja, sedangkan masih banyak terdapat variabel-variabel lainnya yang diduga dapat memberi pengaruh terhadap kinerja karyawan. Kata Kunci: Knowledge Sharing, Lingkungan Kerja, Kinerja Karyawan
PENGARUH PERPUTARAN KAS DAN PERPUTARAN MODAL KERJA TERHADAP NET PROFIT MARGIN PADA PT. MALINDO FEEDMILL TBK.
Authors: Nurhardinnas Nurhardinnas , Pratiwi Aliah , Wulandari Wulandari 
Published: August 2024

Abstrak - Penelitian ini bertujuan untuk mengetahui pengaruh perputaran kas dan perputaran modal kerja terhadap Net Profit Margin (NPM), perputaran kasdan perputaran modal kerja terhadap net profit margin pada pt malindo feedmill tbk. Instumen penelitian ini yaitu menggunakan laporan keuangan di antara laporan neraca dan laba rugi pad apt malindo feedmill tbk adapundata yang digunakan dalam instrument penelitianyaitu data penjualan, pendapatan, modal kerja, dan laba dari tahun 2013-2022. Sedangkan teknik pengambilan sempel yang digunakan adalah purposive sampiling, kriterianya didasarkan pada ketersedian data terkini dan data variabel penelitian yang akan digunakan. Data dalam penelitian ini diolah mengunakan SPSS. Metode pengujian hipotesis menggunakan taraf signifikan 5%. Hasil penelitian menunjukan bahwa perputaran kas berpengaruh signifikan terhadap net prpfit margin (NPM), perputaran modal kerja berpengaruh signifikan terhadap net profit margin (NPM), dan perputaran kas dan perputaran modal kerja berpengaruh signifikan terhadap Net profit margin (NPM).
PENGARUH GAYA HIDUP DAN KELAS SOSIAL TERHADAP KEPUTUSAN BERKUNJUNG PADA CAFÉ SUNSHINE KOTA BIMA
Authors: Sebrio Sberio , Purnama Ita , Hamidah Nur Khusnul 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui Gaya Hidup Dan Kelas Sosial Terhadap Keputusan Berkunjung Pada Café Sunshine Kota Bima. Jenis penelitian ini adalah Asosiatif untuk mengetahui hubungan sebab akibat antara dua variable atau lebih, populasi yang dipake dalam penelitian ini dikota bima dengan jumlahnya tidak diketahui (unknow population) dimana sampel yang digunakan yaitu sebesar 55 dengan teknik purposive sampling. Teknik pengumpulan data yaitu melalui observasi, kuesioner, studi pustaka dengan menggunakan teknik analisa data uji validitas, realiabilitas, uji asumsi klasik, uji regresi linear berganda, determinasi dan korelasi uji t dan uji f. Hasil penellitian yang dilakukan oleh peneliti yaitu 1.) pengaruh gaya hidup (X1) berpengaruh secara signifikan dengan nilai t-hitung sebesar 3.579 t-tabel sebesar 2.007 dengan nilai signifikansi 0,001 0,05 2.) pengaruh kelas sosial (X2) berpengaruh secara signifikan dengan nilai t-hitung sebesar 3.439 t-tabel sebesar 2.007 dengan nilai signifikansi 0,001 0,05 3.) gaya hidup dan kelas sosial berpengaruh secara simultan terhadap keputusan berkunjung pada café sunshine kota bima dengan f-hitung sebesar 23.273 f-tabel sebesar 3,18 dengan signifikansi sebesar 0,000 0,05 maka disimpulkan bahwa hipotesis ketiga yang menyatakan bahwa “ Gaya Hidup Dan Kelas Sosial Persepsi berpengaruh secara simultan.
Socio-Demographic Characteristics Associated With Dental Caries among Patients Attending Malindi Sub-County Dental Clinic, Kenya
Authors: Ajuck Hossan , Magu Dennis , Kibiti Cromwell , Mwiti Kirimi 
Published: August 2024

Purpose: The goal of this study was to determine socio-demographic characteristics associated with dental caries among patients attending dental clinic at Malindi sub-county.
Methodology: The study design was a cross-sectional descriptive study design consisting of 223 participants. This study took place at the Malindi Sub County Dental Clinic. A systematic random sampling method was used to pick the participants on a daily basis until we had contacted all the eligible individuals and enrolled them. This study was done from March, 2023 to November, 2023 approved by ERC reference (ISERC/MSc/041/2022). The pretested questionnaire was used for collecting data on socio-demographic characteristics associated with dental caries among patients attending dental clinic at Malindi sub-county. The data were analyzed using statistical package for the Social Sciences (SPSS) Version 21.The descriptive statistics were done on socio-demographic factors, associated with the dental caries among dental patients seeking services in Malindi Sub County. The data was presented in frequency tables. Ethical approval no P688/09/2016) was obtained.
Findings: The study recruited 223 participants, 117 (52.5%) female and 106 (47.5%) males. Of the 223 participants, 49 (21.9%) were less than 18 years old, 63 (28.3%), 76 (34.1%) and 35(15.7%) were 18 to 29, 30 to 49 and ≥50 years old respectively. The prevalence of dental caries found in this study was 72.6% among patients attending Malindi sub county Hospital dental clinic. The socio-demographic factors, associated with the dental caries were those aged 18- 29 years who were 2 times at risk of having dental caries as compared with those aged less than 18years old. Almost two-thirds (n=138, 61.9%) reported to occasionally use sugary food, 72 (32.3%) moderately sugar exposures per day.
Unique Contribution to Theory, Practice and Policy: This study revealed a high prevalence of dental caries among patients visiting the dental clinic in Malindi Hospital. The demographic factors associated with dental caries were among ages 18 to 29 years old. Oral health care should focus on addressing dental caries and emphasized in the policies by Ministry of health aimed at mitigating dental caries among this age group.
ANALISIS FISIK,KIMIA DAN ORGANOLEPTIK TEPUNG KULIT PISANG KEPOK (Musa acuminata x balbisiana) DALAM PENGOLAHAN KUE BAY TAT
Authors: Moulina Methatias 
Published: August 2024

Kue bay tat adalah kue tradisional khas Provinsi Bengkulu berbahan baku tepung terigu yang mempunyai karakteristik menyerupai bolu dengan selai nanas di atasnya. Telah dilakukan penelitian yang bertujuan untuk menganalisis pengaruh substitusi tepung kulit pisang terhadap sifat fisik, kimia dan organoleptik kue bay tat. Penelitian menggunakan rancangan faktorial dengan 1 perlakuan dan 5 faktor perlakuan, yaitu perbandingan komposisi tepung terigu dan tepung kulit pisang kepok (0 : 100; 20 : 80; 40 : 60; 60 : 40 dan 80 : 20). Analisis yang dilakukan terdiri dari analisis tekstur, kadar air, kadar serat, kadar karbohidrat dan analisis tingkat kesukaan panelis terhadap warna, rasa dan tekstur). Rendemen kue bay tat berkisar antara 80,33 – 85,71 %. Semakin tinggi tepung kulit pisang kepok yang disubstitusikan, kue bay tat yang dihasilkan memiliki tekstur yang semakin keras (12,00 – 45,33 mm/dtk), kadar air yang semakin tinggi (18,53 – 19,87 %), kadar karbohidrat yang semakin tinggi (55,34 – 56,87 %) dan kadar serat yang semakin tinggi (0,74 – 5,17 %). Tingkat kesukaan panelis terhadap kue bay tat berkisar antara 2,45 – 4,60 (agak suka – suka) untuk parameter warna, 1,85 – 4,30 (tidak suka – suka) untuk parameter rasa dan 1,9 – 3,75 (tidak suka – suka) untuk parameter tekstur. Produksi kue bay tat dengan substitusi tepung kulit pisang menghasilkan keuntungan sebesar Rp. 35.000,- per loyang berukuran 20x20 cm.

Kata kunci : mutu, tekstur, kimia, tingkat kesukaan
RELATIONSHIP BETWEEN PARENTS’ LEVEL OF EDUCATION AND PUPIL’S ACADEMIC PERFORMANCE IN SELECTED PRIMARY SCHOOLS IN KAYUNGA DISTRICT. A CROSS SECTIONAL-STUDY.
Authors: MUGULA ISMAIL , TUGUME PATIENCE 
Published: August 2024

Background
Academic performance among pupils is influenced by numerous factors. Yet, excelling in academics is important in ensuring pupils not only pass exams but also lead rewarding lives. This study sought to determine the relationship between the parent’s level of education and pupils’ academic performance in primary schools.
Methodology
A mixed-method research approach was used in this study to generate data from 453 respondents drawn from eight primary schools in the Kayunga district. Using questionnaires and interview guides, data was collected from pupils, teachers, head teachers, parents, and the Area Education Officer.
Results
The correlation findings indicated a positive relationship between parents’ level of education and pupils’ academic performance (r = 0.297**, p =, 0.000) thus there was a positive relationship between parents’ level of education and pupils’ academic performance in Kayunga District.
Conclusion
There is a significant positive relationship between parents’ level of education and pupils’ academic performance. Attributed to parents checking books and homework of their children, assisting pupils in doing their homework, and assigning minimal domestic work to pupils at home to allow them to revise. Some of the parents visit schools to follow up on the academic progress of their pupils.
Recommendation
The study strongly recommends that parents should be made aware of the importance of the home environment in their children's academic performance. Teachers, educationists, and leaders should create awareness among parents of the importance of the home environment in improving the academic performance of pupils.
THE LOCAL GOVERNMENT POLICY IN BORDER AREA ON THE EDUCATION RIGHTS FULFILMENT FOR PERSON WITH DISABILITIES IN NORTH KALIMANTAN PROVINCE
Authors: Zein Yahya Ahmad , Rohman Arif , Nurvianti Dewi 
Published: August 2024

The research problems are; first, how is local government authority within human rights fulfilment for person with disabilities? Second, how is legal policy on human rights for person with disabilities?. Third, how is law protection from local government related to education rights fulfiment for person with disabilities in North Kalimantan?. The method of this research uses normative method be equipped by field research. This research is important considering the obligation of state to protect, to recognize and to fulfil of human rights for citizens in its region without discrimination particulary for person with disabilities in border area. Within an effort to implementation, Indonesia Government regulates some legal instrument of human rights, one of the newest is Law No 8 of 2016 on Person with Disabilities. North Kalimantan is youngest province in Indonesia, some local regulation on human rights has been regulated, but the human rights instrument particulary for person with disabilities has not been set up. The research urgency becomes one of the goals to regulate the local government policy on education rights particularly the rights of person with disabilities in North Kalimantan Province, its expected to be a solution against regulation plan in Indonesia on fulfilment of human rights degree for person with disabilities especially education rights for them in North Kalimantan Province. The methodology of this paper is normative that equipped by field research. The conclussion of this paper is in regulation, authority, and legal protection.