bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMMUNOLOGICAL ASPECTS OF LEPROSY
Authors: Bhutani Lalit K. 
Published: April 2015

ABSTRACTLeprosy has been regarded as a host dependent disease that presents an immunological spectrum. Various parameters of in vivo and in vitro cell‐mediated and humoral responses in different forms of leprosy were studied. Lepromatous leprosy patients showed hyper gammaglobulinemia with significantly elevated levels of IgG and IgA while tuberculoid leprosy patients showed raised IgG levels.Cutaneous reactions to lepromin antigen were significantly depressed in patients with lepromatous leprosy while those to PPD were normal. Mitogenic response of peripheral leucocytes to phytoheamagglutinin was considerably depressed in untreated lepromatous leprosy and normal in tuberculoid leprosy. Dapsone‐treated patients with lepromatous leprosy showed a normal or enhanced response. Contributory factors were also found in plasma. T‐lymphocytes were significantly reduced in lepromatous leprosy with high bacillary load. B‐cells were increased in lepromatous patients. Tuberculoid leprosy patients had normal values.Phagocytic and bacteriolytic activity of blood derived macrophages was not altered in the lepromatous or tuberculoid patients.
GLYCOPROTEIN IN CULTURED HUMAN SKIN FIBROBLASTS
Authors: Maekawa Yoshihiro , Shinkai Hiroshi , Sano Shigeharu 
Published: April 2015

ABSTRACTA unique glycoprotein has been isolated from cultured human embryonic fibroblasts and their culture medium. Analysis showed a composition of 17.5 γ/mg uronic acid, 40 γ/mg hexosamine, and 93.5 γ/mg sialic acid. Gas chromatography revealed fucose, mannose, galactose, and glucose. Ten percent acrylamide 0.1% sodium sulfate acrylamide disc electrophorisis of the glycoprotein after treatment with 6 M urea showed a RF ratio of 0.3 and a molecular weight of about 95,000. The protein content was 454 γ/mg and amino acid analysis revealed high contents of aspartic acid, threonine, glutamic acid, alanine, and leucine.The existence of acidic glycoproteins in human fibroblasts suggests an association with collagen fibril maturation and may be of etiologic and diagnostic significance in connective tissue disease of the skin.
THE ENZYMATIC DETERMINATION OF ACIDIC GLYCOSAMINOGLYCANS IN SCAR AND KELOID WITH CHONDROITINASE
Authors: Sasaki Soichiro , Akashi Yukio 
Published: April 2015

ABSTRACTAcidic glycosaminoglycans (GAG) prepared from scar and keloid, was assayed for separation and quantitative measurement with the paper chromatographic characteristic of the unsaturated disaccharide unit after chondroitinase digestion. The following results were obtained:

It was found that the total amount of GAG in scars was greatly increased, especially in earlier phases, in comparison with that of normal tissue, and it gradually decreased with time. Even in different phases of scar, a decrease of hyaluronic acid (HA) was commonly observed in contrast to an increase in sulfated GAG, i.e. dermatan sulfate (DS) in particular amoung constituents.
A similar behavior of GAG to their mentioned above was observed in keloid specimens.
Any striking difference of GAG constituents between the scar in the hypertrophic phase and the keloid remained indistinguishable.
AN UNUSUAL HAIR FOLLICLE TUMOR—AN INTIMATE RELATIVE OF TRICHOGENIC ADNEXAL TUMOR (HEADINGTON AND FRENCH)
Authors: Arata Jirô 
Published: April 2015

ABSTRACTWe have presented here an unusual tumor of the hair follicle which did not correspond exactly to any hitherto described hair follicle tumor. This tumor was characterized by an intimate stromal‐epithelial interaction, unmistakable morphodifferentiation towards hair follicle, formation of hair‐like structures and pluripotential adenomatous deviation. In 1962 Headington and French described a tumor to which they gave the noncommital term “trichogenic adnexal tumor”. They thought it was a hair matrix neoplasm in which morphodifferentiation towards hair follicle is distinct and is induced by intimate stromal‐epithelial relationship. In this sense our tumor is considered to be in the category of trichogenic adexal tumor, or at least its intimate relative, although the tumor presented here was better organized with a more complicated adenomatous deviation. It will surely be important as another example for further analysis of hair follicle tumors.
SIGNIFICANCE OF IN VIVO‐BOUND IMMUNOGLOBULINS AND COMPLEMENT IN THE SKIN OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS
Authors: Deng Jau‐Shyong , Lin Ruey‐Yi , Lü Yau‐Chin 
Published: April 2015

ABSTRACTA direct immunofluorescent test was used to demonstrate the in vivo deposits of immunoglobulin (Ig) and complement in the skin of 30 patients with systemic lupus erythematosus (SLE). These deposits were demonstrated in all skin lesions and in 70% of apparently normal skin of patients with lupus nephritis. On the contrary, they were seldom found in seemingly normal skin of patients without nephritis, though they could be seen in skin lesions. There was significant difference between these two groups and as well as an intimate relation of the deposits to clinical severity. The fixed Ig and/or complement could be found in a band arrangement in the basement membrane zone (BMZ) area, nuclear areas of epidermal and/or dermal cells or both BMZ area and nuclear areas.
STAPHYLOCOCCAL SCALDED SKIN SYNDROME
Authors: Nishioka Kiyoshi , Nakano Toshiko , Hirao Nobuyuki , Asada Yasuo 
Published: April 2015

ABSTRACTExfoliatin, an exotoxin produced by phage group 2 staphylococci, was separated and was analyzed. The toxin was separated in a single peak by Sephadex G‐100 gel filtration and subsequent DEAE Sephadex chromatography. By acrylamide gel disc electrophoresis this single peak was found to contain 2 components both of which posessed exfoliative activity and the same antigenic properties. Their molecular weight, however, differed; the major component had a molecular weight of 30,000 and the minor component had 27,000. The toxin was stable when heated at 60°C for 40 minutes, and labile at 100°C for 20 minutes.The toxin was immunogenic to mice and produced antibody Which could be transmitted to neonatal mice to neutralize exfoliative activity of the toxin. Innoculation of the bacteria caused the production of antibodies against both exfoliatin and α‐hemolysin in mice. The antibodies were also transmitted to neonatal mice to neutralize the exfoliative activity of exfoliatin.
STAPHYLOCOCCAL SCALDED SKIN SYNDROME
Authors: Nishioka Kiyoshi , Nakano Toshiko , Hirao Nobuyuki , Teranishi Harumitsu , Asada Yasuo 
Published: April 2015

ABSTRACTIn order to study the differences between staphylococcal scalded skin syndrome (SSSS) and bullous impetigo, the anti exfoliatin level was assessed in the sera from both groups of patients, and no significant difference in the level was found. However a significant difference was noted in the anti α‐toxin levels in sera from both group of patients; that of SSSS patients was much lower than that of impetigo patients and of children in a control group. Five out of 6 patients with SSSS showed an unchaged level of anti α‐toxin at the second examination, while an increased anti exfoliatin level was noted in 4 out of 6 SSSS patients.
A CASE OF MINOCYCLINE‐INDUCED FIXED DRUG ERUPTION
Authors: Shimizu Yasuyuki , Shimao Shuhei 
Published: April 2015

ABSTRACTA case of fixed drug eruption induced by minocycline on the glans penis of a 26‐year‐old man is reported. Later oral administration of minocycline reproduced the same type of eruption, but tetracycline, possessing the same starting structure as minocycline, did not induce the eruption. Laboratory findings were normal. This seems to be the first case of fixed drug eruption induced by minocycline to appear in the literature.
A PECULIAR ACANTHOLYTIG DERMATOSIS
Authors: Saito Ryuzo , Kamata Naoko 
Published: April 2015

ABSTRACTThis paper reports a peculiar case seen in a 36‐year‐old woman who every summer since the age of 30 has developed numerous solitary vesicles or crusted papules with intense pruritus in the seborrheic zones. There are no general symptoms and no hereditary relations. The individual rash disappears completely in a week to a month and there is no eruption in winter.The clinical picture resembles that of Darier's disease, but histopathological tests reveal intraepidermal cleft or bulla formation due to acantholysis but no dyskeratosis. Clinicopathological consideration indicates a disease akin to familial benign chronic pemphigus, but as our case does not correspond to any known disease, it is therefore reported as a peculiar acantholytic dermatosis.
PURINE PHOSPHORIBOSYLTRANSEERASE ACTIVITIES IN GUINEA PIG EPIDERMIS
Authors: Matsuo Itsuro , Ohkido Muneo , Kizaki Harutoshi , Sakurada Tomomi 
Published: April 2015

ABSTRACTPurine phosphoribosyltransferase activities in normal and experimental hyperkeratotic epidermis of guinea pig skin were demonstrated quantitatively by a new microassay method.The ratio of HGPRTase with hypoxanthine as a substrate to APRTase activity in normal and hyperkeratotic epidermis was found to be 0.94 and 0.60, respectively. The HGPRTase and APRTase activities expressed as μmoles per gram wet weight per min. were increased in experimental hyperkeratotic epidermis and it is suggested that the salvage pathway for purine nucleotide biosynthesis is activated in experimental hyperkeratotic epidermis.The pH optimum of these enzymes and their stability in the frozen state were also demonstrated.
A CASE OF EOSINOPHILIC LYMPHFOLLICULOSIS OF THE SKIN (KIMURA'S DISEASE)
Authors: Inada Shuichi , Yamamoto Shoso , Kitaura Hiroyuki , Yamura Takuso 
Published: April 2015

ABSTRACTEosinophilic lymphfolliculosis of the skin (Kimura's disease) in a 31‐year‐old male is reported. He had two subcutaneous tumors, 10 × 9 × 3 cm and 9 × 7 × 2 cm in size, in the right retroauricular and submaxillary areas respectively.Histopathologic examination of the tumors showed marked infiltration of eosinophils, mast cells and lymphocytes, and angiomatous proliferation of blood vessels from the dermis to the skeletal muscular tissue. In subcutaneous adipose tissue, there were numerous lymphfollicles with germinal centers in which IgE deposition with reticular appearance was observed by immunofluorescent technique. Study of the peripheral blood showed marked eosinophilia and an increase of serum IgE level.These findings suggest the possibility that Type 1 allergic reaction may be involved in the histogenesis of eosinophilic lymphfolliculosis of the skin, although there is no direct evidence for the existence of antigens which react to IgE antibody in the skin lesion.
EXPERIMENTAL HYPERKERATOSIS
Authors: Ohkawara Akira , Mizumoto Toshihiro , Ohkuma Noritaka , Honda Saho 
Published: April 2015

ABSTRACTThe following conclusions will be drawn from the data obtained in this study.

Topical VA ointments which contain 5,000 IU and 10,000 IU VA respectively could not prevent n‐hexadecane‐induced epidermal proliferation and hyperkeratosis during the period studied.
After the epidermal hypertrophy and hyperkeratosis were established, continuous application of VA ointments of 5,000 IU and 10,000 IU resulted in even greater activity of the enzymes than those observed with the control (hydrophilic ointment alone).
Judging from the data obtained from the present study, VA ointment can be useful in the treatment of hyperkeratotic conditions characterized by the normal or decreased epidermal proliferation, because they promote the epidermal metabolic rate.
PEMPHIGUS: A SURVEY OF 85 PATIENTS BETWEEN 1970 AND 1974
Authors: Hirone Takae 
Published: April 2015

ABSTRACTA survey was made of 85 cases of pemphigus seen at the dermatology departments of 11 Japanese universities from 1970 to 1974. The overall mortality for all types of pemphigus was 8%. The mortality from pemphigus vulgaris and pemphigus vegetans treated with systemic corticosteroids was 11%. An analysis of the data indicated that 88% of patients with pemphigus vulgaris and pemphigus vegetans were controlled with 100mg of a prednisone equivalent or less daily, and supported the view that both mortality and incidence of therapy complications closely correlate with the maximum daily dose of steroids required to bring about remission. The suggestion is that in the treatment of pemphigus better results may be obtained with moderate rather than high doses of steroid.
MULTIPLE BOWEN'S DISEASE OBSERVED IN FORMER WORKERS OF A POISON GAS FACTORY IN JAPAN, WITH SPECIAL REFERENCE TO MUSTARD GAS EXPOSURE
Authors: Inada Shuichi , Hiragun Keiko , Seo Koichi , Yamura Takuso 
Published: April 2015

ABSTRACTA study was made on five cases of multiple Bowen's disease observed in former workers of a poison gas factory which was in operation from 1929 to 1945 at Okunojima, Hiroshima, Japan. The age of these patients ranged from 63 to 70 years with an average of 66 years. The period engaged in poison gas production averaged 9.3 years. The averaged interval from initiation of the poison gas production to determination of diagnosis of Bowen's disease was 39.2 years. All five patients were engaged in the production of mustard gas which is a vesicant poison gas and an alkylic agent. The number of lesions of Bowen's disease in a patient ranged from 2 to 7. Ten lesions were found on the trunk and 13 on the extremities. In addition, there were numerous pigmented and depigmented spots and hyperkeratotic papular eruptions on the skin of all patients.There are no reports in the literature on Bowen's disease caused by mustard gas. The results of this study strongly suggest that multiple Bowen's disease in workers formerly engaged in the production of poison gas is caused by exposure of mustard gas experimentally demonstrated to be a carcinogen.
PRURIGO PIGMENTOSA
Authors: Nagashima Masaji 
Published: April 2015

ABSTRACTClinical observations of fourteen Japanese patients with prurigo pigmentosa, a peculiar pruritic pigmented dermatosis, were reported. Clinically the dermatosis is characterized by the sudden appearance of reddish papules accompanied by severe pruritus. Gross reticular pigmentation occurred after the disappearance of the papules. Histopathological findings of the papular lesions are non‐specific, although they show lichenoid tissue reactions. The dermatosis shows some preference for females, particularly in adolescence. Sites of predilection are the back, the nucha, the clavicular regions and the chest. Although the cause of the disease still remains unknown, it is speculated that some unknown environmental contaminant in today's Japan may play a role in the development of this dermatosis.
STUDIES ON SKIN SURFACE BARRIER FUNCTIONS—SKIN SURFACE LIPIDS AND TRANSEPIDERMAL WATER LOSS IN ATOPIC SKIN DURING CHILDHOOD—
Authors: Abe Takashi , Ohkido Muneo , Yamamoto Kazuya 
Published: April 2015

ABSTRACTThe relationship between skin surface lipids and transepidermal water loss (TWL) was investigated in 22 children with atopic skin.TWL values and casual and replacement lipids were measured by electro‐hygrometric and gravimetric methods respectively. Free and total cholesterol and squalene were measured by gas chromatography.The inverse correlations between casual lipids, especially total cholesterol, and TWL exhibited in the normal adult and juvenile skin were not found in the atopic skin.In addition, a significant increase in TWL and decrease in sebaceous lipids was characteristic of atopic skin.In conclusion, the inhibitory action of epidermal cholesterol on TWL is considered to exist only when the skin has a normal keratinization process.
A CASE OF SENSITIZATION TO ORAL CORTICOSTEROIDS
Authors: Shigemi Fumio , Tanaka Masasuke , Ohtsuka Toshio 
Published: April 2015

ABSTRACTA 29 year‐old woman who developed generalized erythematous eruptions after oral treatment with predonisolone tablets for facial dermatitis is described. Patch tests showed a positive reaction to both predonisolone tablets diluted in cream and a commercial predonisolone ointment. After oral challenges with 5mg predonisolone in tablet form and 4mg predonisolone powder, similar eruptions reappeared the next day. In both patch and dose testing with many kinds of corticosteroids, the patient showed a cross‐sensitivity to methyl‐predonisolone and its acetate only.
HISTOGENESIS OF HYALINOSIS CUTIS ET MUCOSAE
Authors: Ishibashi Akira 
Published: April 2015

ABSTRACTLight microscopically, reticulum fibers and argyrophilic materials were found by reticulum staining, and lipid droplets by Sudan III staining, around the blood vessels and in the interstices of the smooth muscle fibers of tunica dartos; toluidine blue staining of thick sections of Epon‐embedded tissue revealed poorly‐stained, glass‐like, amorphous hyalin with configuration of collagen fibers in the same areas and hyalinized muscle fibers in tunica dartos.Electron microscopy disclosed that multiplication of the basal lamina and its transition to the fibrogranular amorphous material, probably a hyalin substance, was seen around the true smooth muscle cells of tunica dartos and also around the blood vessels. In addition, dilated rough‐surfaced endoplasmic reticulums with fibrogranular content were often observed in the endothelial cells, pericytes, and smooth muscle cells, with Golgi apparatus in some parts.These findings suggest that hyalinosis cutis et mucosae is due to the accumulation and invasion of hyalin into the normal collagen fibers due to a genetic abnormality in the synthetic processes of smooth muscle cells, vascular endothelial cells, pericytes and some fibroblast‐like connective tissue cells. In my speculation, the hyalin substance in this disease may be normal collagen invaded by basal lamina glycoprotein, most probably involving type III and/or type IV collagen.
PROLIFERATING TRICHILEMMAL CYST ON THE BACK
Authors: Yoshikawa Kunihiko , Nakanishi Ayako 
Published: April 2015

ABSTRACTA large intradermal tumor, 5times4 cm in size, developed on the back of 67‐year‐old Japanese woman.Histological examination revealed a large cyst next to a mass of irregular proliferation of the cystic wall, most of which showed typical trichilemmal keratinization. The accompanying partial calcification of the homogeneous cystic content allowed the diagnosis of proliferating trichilemmal cyst.Since this tumor is quite rare among the Japanese, the 15 cases so far reported in the Japanese literature are reviewed and summerized.
AXILLARY INVOLVEMENTS IN GENITAL PAGET'S DISEASE
Authors: Miki Yoshiharu , Kawatsu Tomoyuki , Kawatsu Tomoko , Yamada Tetsutaro , Okada Tetsuya 
Published: April 2015

ABSTRACTSimultaneous occurrence of bilateral axillary Paget's disease in a 61‐year‐old male with genital Paget's disease of 2 years' duration was presented. Invasive adenocarcimoma was found in the genital lesion. No regional lymph node metastases ware apparent. The lesions were excised in toto. There has been no recurrence 14 months later.Four previously reported cases of double or triple extramammary Paget's disease, together with two more cases were summarized. Generally, the axillary lesions were clinically insignificant, faintly erythematous patches and could hardly be identified without histological examination.
GAMMA‐GLUTAMYL TRANSPEPTIDASE ACTIVITY IN HUMAN SKIN
Authors: Kim Young Pio , Kahng Johng Bong 
Published: April 2015

ABSTRACTGamma‐glutamyl transpeptidase (γ‐GT) activity was measured in a homogenate of penile foreskin, using γ‐glutamyl‐p‐nitroanilide as a substrate. It was found that γ‐GT activity was present in both the epidermis and the dermis, being more active in the former.The optimum pH for the enzyme was 8.5–9.0 in Tris buffer, which is similar to that for the rat kidney and human serum enzymes. It was also revealed that glycylglycine was the most effective activator of the enzyme. Some activation was also observed in the presence of L‐glutamine. But L‐methionine, L‐homoserine, L‐glutamic acid, L‐arginine, L‐aspartic acid, glycine and L‐valine inhibited the activity, suggesting that these amino acids do not act as acceptors of the γ‐glutamyl moiety. The enzyme was remarkably inhibited by bromsulphalein, oxidized glutathione, and by L‐serine in the presence of borate. These inhibitions were more severe than thoes observed with rat kidney and human serum enzymes.
CUTANEOUS ALTERNARIOSIS
Authors: Mikoshiba Hajime , Okubo Seiki , Wakamatsu Katsuo , Nijo Sadako 
Published: April 2015

ABSTRACTA 37‐year‐old man has had a skin lesion on his left cheek for twenty‐five years. After ten years his right cheek also became involved. Alternaria alternata was isolated from the biopsy tissue. The upper and middle parts of the dermis were the site of a granulomatous inflammation in which there were many giant cells containing round spore‐like bodies. In PAS‐stained sections the walls of the spore‐like bodies stained positive.
ERYTHEMA ELEVATUM DIUTINUM DEVELOPING SQUAMOUS CELL CARCINOMA
Authors: Idemori Masahiro , Arao Tatsuyoshi 
Published: April 2015

ABSTRACTAfter a 25‐year history of erythema elevatum diutinum involving the extremities and later the face and the buttocks in a 70‐year‐old Japanese man, squamous cell carcinoma developed from one of the lesions on the right foot. Histological examination of erythema elevatum diutinum revealed leukocytoclastic angiitis of the upper dermal vessels and perivascular fibrosis. DDS was not effective for erythema elevatum diutinum.
REFLECTION ULTRAVIOLET PHOTOGRAPHY IN DERMATOLOGY
Authors: Kikuchi Ichiro , Idemori Masahiro , Uchimura Hideo , Inoue Shohei 
Published: April 2015

ABSTRACTBecause reflection ultraviolet photography in dermatology records the reflected ultraviolet radiation (UVR), the data include information on relatively superficial changes such as of the skin. Dermatologic applications are discussed in detail. UV photography is indicated when one wants 1) to reveal minute changes of the surface 2) to intensify the changes of the upper skin and to erase the changes of lower skin and 3) to find if there is any change in the reflection of UVR in a given skin lesion.
IMMUNOPATHOLOGICAL STUDIES ON PSORIASIS
Authors: Kohda Mamoru , Gotoh Masako , Mimura Shigeru , Namba Masako , Nakagawa Shojiro , Ueki Hiroaki 
Published: April 2015

ABSTRACTIn vivo deposits of fibrin, fibrinogen, plasminogen, complements and immunoglobulins were observed using immunofluorescent (IF) staining of psoriatic lesions. Deposits of fibrin were seen in either the horny layer or the dermal papillae. A linear cytoplasmic appearance of fluorescence in the psoriatic scales was a common pattern of the staining. IF staining of the psoriatic horny layer for fibrinogen and plasminogen yielded essentially the same pattern as those of fibrin and IgG.These findings suggest that some fibrinolytic processes may be associated with an immune reaction in psoriatic skin, although they be secondary phenomena.
ATRICHIA WITH PAPULAR LESIONS ASSOCIATED WITH GASTROINTESTINAL POLYPOSIS
Authors: Ishii Yoshimitsu , Kusuhara Toshiyuki , Nagata Takashi 
Published: April 2015

ABSTRACTA 41‐year‐old Japanese male presented extensive polyposis involving the stomach, deodenum, jejunum, ileum, colon and the rectum; atrichia, pigmentation and epidermal cysts. This case does not fit any of the known syndromes, including Peutz‐Jeghers syndrome, Gardner's syndrome, Cronkhite‐Canada syndrome and atrichia with papular lesions. We diagnosed it as atrichia with papular lesions associated with gastrointestinal polyposis.
MULTIPLE SUBCUTANEOUS LIPOGRANULOMAS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS‐LIKE SYMPTOMS
Authors: Ishizaki Hiroshi , Sano Tsutomu , Kawashima Yoshio , Fukushiro Ryoichi , Takashima Tsutomu 
Published: April 2015

ABSTRACTA case of a 45 year old woman with multiple subcutaneous nodules and systemic lupus erythematosus‐like symptoms is reported. Histologically the nodules were identical to sclerosing lipogranuloma. The oily substance within the nodules was suspected to be due to depot penicillin injected ten years before. The patient was treated with corticosteroids and finally died of pulmonary fibrosis. This case may be included in the entity of adjuvant diseases of man.