bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonsuicidal Self‐Injury among Adolescents: A Training Priority for Primary Care Providers
Authors: Taliaferro Lindsay A. , Muehlenkamp Jennifer J. , Hetler Joel , Edwall Glenace , Wright Catherine , Edwards Anne , Borowsky Iris W. 
Published: April 2013

Primary care providers were surveyed to determine how prepared they feel to address nonsuicidal self‐injury (NSSI) among adolescents, their interest in training on NSSI, and factors associated with routinely asking about NSSI when providing health supervision. Participants included family medicine physicians (n = 260), pediatricians (n = 127), family nurse practitioners (n = 96), and pediatric nurse practitioners (n = 54). Almost 50% felt unprepared to address NSSI, and over 70% wanted training in this area. Overall, relative to other areas of mental health care, clinicians felt least prepared to address and wanted more training on NSSI. Just 27% reported they routinely inquired about NSSI during health supervision. Factors associated with routinely asking about NSSI were identifying as female (OR = 2.37; 95% CI = 1.25–4.49), feeling better prepared to address NSSI (OR = 1.51; 95% CI = 1.04–2.20), and more frequently using a psychosocial interview to identify adolescents in distress (OR = 1.23; 95% CI = 1.02–1.48). Teaching clinicians to assess NSSI within a psychosocial interview may increase screening for and identification of the behavior among adolescents in primary care.
miR396 affects mycorrhization and root meristem activity in the legume Medicago truncatula
Authors: Bazin Jérémie , Khan Ghazanfar Abbas , Combier Jean‐Philippe , Bustos‐Sanmamed Pilar , Debernardi Juan Manuel , Rodriguez Ramiro , Sorin Céline , Palatnik Javier , Hartmann Caroline , Crespi Martin , Lelandais‐Brière Christine 
Published: April 2013

SummaryThe root system is crucial for acquisition of resources from the soil. In legumes, the efficiency of mineral and water uptake by the roots may be reinforced due to establishment of symbiotic relationships with mycorrhizal fungi and interactions with soil rhizobia. Here, we investigated the role of miR396 in regulating the architecture of the root system and in symbiotic interactions in the model legume Medicago truncatula. Analyses with promoter–GUS fusions suggested that the mtr‐miR396a and miR396b genes are highly expressed in root tips, preferentially in the transition zone, and display distinct expression profiles during lateral root and nodule development. Transgenic roots of composite plants that over‐express the miR396b precursor showed lower expression of six growth‐regulating factor genes (MtGRF) and two bHLH79‐like target genes, as well as reduced growth and mycorrhizal associations. miR396 inactivation by mimicry caused contrasting tendencies, with increased target expression, higher root biomass and more efficient colonization by arbuscular mycorrhizal fungi. In contrast to MtbHLH79, repression of three GRF targets by RNA interference severely impaired root growth. Early activation of mtr‐miR396b, concomitant with post‐transcriptional repression of MtGRF5 expression, was also observed in response to exogenous brassinosteroids. Growth limitation in miR396 over‐expressing roots correlated with a reduction in cell‐cycle gene expression and the number of dividing cells in the root apical meristem. These results link the miR396 network to the regulation of root growth and mycorrhizal associations in plants.
Evaluating noise reduction techniques while considering anatomical noise in dual‐energy contrast‐enhanced mammography
Authors: Allec Nicholas , Abbaszadeh Shiva , Scott Chris C. , Karim Karim S. , Lewin John M. 
Published: April 2013

Purpose:The authors describe modifications to previously developed cascaded systems analysis to include the anatomical noise in evaluation of dual‐energy noise reduction techniques. Previous models have ignored the anatomical noise in theoretical analysis of noise reduction techniques. The inclusion of anatomical noise leads to more accurate estimation of potential noise reduction improvements and optimization.Methods:The model is applied to dual‐energy contrast‐enhanced mammography. The effect of linear noise reduction filters on the anatomical noise is taken into account using cascaded systems analysis. The noise model is included in the ideal observer detectability for performance evaluation of the noise reduction techniques.Results:Dual‐energy image noise with and without including the effect of anatomical noise in noise reduction technique analysis is reported. The theoretical model is compared with clinical images from a previous dual‐energy contrast enhanced mammography clinical study and good agreement is observed. The results suggest that the inclusion of anatomical noise in the evaluation and comparison of noise reduction techniques is highly warranted for more accurate analysis.Conclusions:This work establishes a useful extension to dual‐energy cascaded systems analysis for maximizing image quality using noise reduction techniques. The extension includes the effect of linear image filtering, such as that used for noise reduction, on anatomical noise. The results suggest that the inclusion of anatomical noise in the evaluation of noise reduction techniques can lead to more accurate optimization, noise, and performance estimations.
Write activity reduction on non-volatile main memories for embedded chip multiprocessors
Authors: Hu Jingtong , Xue Chun Jason , Zhuge Qingfeng , Tseng Wei-Che , Sha Edwin H.-M. 
Published: April 2013

Recent advances in circuit and semiconductor technologies have pushed Non-Volatile Memory (NVM) technologies into a new era. These technologies exhibit appealing properties such as low power consumption, non-volatility, shock-resistivity, and high density. However, there are challenges to which we need answers in the road of applying non-volatile memories as main memory in embedded computer systems. First, when compared with DRAM, NVMs have a limited number of write/erase cycles. Second, write activities on NVM are more expensive than DRAM memory in terms of energy consumption and access latency. Both challenges will benefit from the reduction of the write activities on the NVMs.
In this paper, we target embedded Chip Multiprocessors (CMPs) with Scratch Pad Memory (SPM) and non-volatile main memory. We introduce scheduling, data migration, and recomputation techniques to reduce the number of write activities on NVMs. Experimental results show that the proposed methods can reduce the number of writes by 58.46% on average, which means that the NVM can last 2.8 times as long as before. For Phase Change Memory (PCM), the lifetime is extended from 2.5 years to about 7 years on average and 15 years at the most. Also, the finish time of the tested programs is reduced by an average of 38.07%, and the energy consumption is reduced by an average of 51.23%.
TLB Improvements for Chip Multiprocessors
Authors: Lustig Daniel , Bhattacharjee Abhishek , Martonosi Margaret 
Published: April 2013

Translation Lookaside Buffers (TLBs) are critical to overall system performance. Much past research has addressed uniprocessor TLBs, lowering access times and miss rates. However, as Chip MultiProcessors (CMPs) become ubiquitous, TLB design and performance must be reevaluated. Our article begins by performing a thorough TLB performance evaluation of sequential and parallel benchmarks running on a real-world, modern CMP system using hardware performance counters. This analysis demonstrates the need for further improvement of TLB hit rates for both classes of application, and it also points out that the data TLB has a significantly higher miss rate than the instruction TLB in both cases.
In response to the characterization data, we propose and evaluate both Inter-Core Cooperative (ICC) TLB prefetchers and Shared Last-Level (SLL) TLBs as alternatives to the commercial norm of private, per-core L2 TLBs. ICC prefetchers eliminate 19% to 90% of Data TLB (D-TLB) misses across parallel workloads while requiring only modest changes in hardware. SLL TLBs eliminate 7% to 79% of D-TLB misses for parallel workloads and 35% to 95% of D-TLB misses for multiprogrammed sequential workloads. This corresponds to 27% and 21% increases in hit rates as compared to private, per-core L2 TLBs, respectively, and is achieved this using even more modest hardware requirements.
Because of their benefits for parallel applications, their applicability to sequential workloads, and their readily implementable hardware, SLL TLBs and ICC TLB prefetchers hold great promise for CMPs.
The McPAT Framework for Multicore and Manycore Architectures
Authors: Li Sheng , Ahn Jung Ho , Strong Richard D. , Brockman Jay B. , Tullsen Dean M. , Jouppi Norman P. 
Published: April 2013

This article introduces McPAT, an integrated power, area, and timing modeling framework that supports comprehensive design space exploration for multicore and manycore processor configurations ranging from 90nm to 22nm and beyond. At microarchitectural level, McPAT includes models for the fundamental components of a complete chip multiprocessor, including in-order and out-of-order processor cores, networks-on-chip, shared caches, and integrated system components such as memory controllers and Ethernet controllers. At circuit level, McPAT supports detailed modeling of critical-path timing, area, and power. At technology level, McPAT models timing, area, and power for the device types forecast in the ITRS roadmap. McPAT has a flexible XML interface to facilitate its use with many performance simulators.
Combined with a performance simulator, McPAT enables architects to accurately quantify the cost of new ideas and assess trade-offs of different architectures using new metrics such as Energy-Delay-Area2 Product (EDA2P) and Energy-Delay-Area Product (EDAP). This article explores the interconnect options of future manycore processors by varying the degree of clustering over generations of process technologies. Clustering will bring interesting trade-offs between area and performance because the interconnects needed to group cores into clusters incur area overhead, but many applications can make good use of them due to synergies from cache sharing. Combining power, area, and timing results of McPAT with performance simulation of PARSEC benchmarks for manycore designs at the 22nm technology shows that 8-core clustering gives the best energy-delay product, whereas when die area is taken into account, 4-core clustering gives the best EDA2P and EDAP.
Long-Term Survival of Patients Undergoing Mitral Valve Repair and Replacement
Authors: Vassileva Christina M. , Mishkel Gregory , McNeely Christian , Boley Theresa , Markwell Stephen , Scaife Steven , Hazelrigg Stephen 
Published: April 2013

Background—
Despite the established superiority of mitral repair over replacement, its adoption in the treatment of elderly patients has not been uniform, partly because of a lack of robust long-term survival data. We present the long-term survival of Medicare fee-for-service beneficiaries undergoing mitral valve repair and replacement over a 10-year period.

Methods and Results—
We used the Medicare database to identify 47 279 fee-for-service beneficiaries ≥65 years of age undergoing primary isolated mitral valve repair or replacement from 2000 to 2009. Operative mortality and long-term survival are presented for repair and replacement. Operative mortality was 3.9% for patients undergoing repair and 8.9% for patients undergoing replacement. The 1-, 5-, and 10-year Kaplan-Meier survival estimates for patients undergoing repair were 90.9%, 77.1%, and 53.6%. The 1-, 5-, and 10-year Kaplan-Meier survival estimates for patients undergoing replacement were 82.6%, 64.7%, and 37.2%. Important predictors of mitral repair included younger age (odds ratio, 1.10; 95% confidence interval, 1.05–1.14), elective admission status (odds ratio, 1.34; 95% confidence interval, 1.27–1.41), and annual mitral procedure volume >40 cases per year (odds ratio, 1.57; 95% confidence interval, 1.36–1.81). Female sex and the presence of comorbidities were associated with a lower likelihood of repair.

Conclusions—
Mitral valve surgery in the Medicare population carries less risk than previously reported. Given the favorable outcomes of elderly patients undergoing mitral valve surgery, especially mitral valve repair, an approach of earlier identification and surgical referral appears justified regardless of age.
Long‐term Efficacy of Specific Immunotherapy on House Dust Mite–Induced Allergic Rhinitis in China
Authors: Peng Hua , Li Chun Wei , Lin Zhi Bin , Li Tian Ying 
Published: April 2013

ObjectiveAlthough the effect of specific immunotherapy (SIT) on allergic rhinitis (AR) has been well documented in developed countries, its long‐term efficacy in patients in developing countries (such as China) is poorly understood. This study investigated the long‐term therapeutic and preventive effects of SIT on house dust mite (HDM)–induced AR in patients from China.DesignHistorical cohort study.SettingUniversity hospital.Subjects and MethodsOne hundred forty‐six AR patients with/without asthma allergic to HDM were investigated for 5 years after initiation of a 3‐year course of subcutaneous SIT (SIT group, n = 106) or no SIT (control group, n = 40). The clinical responses of all patients were evaluated at baseline, the stop point of SIT (third year), and 2 years after SIT termination (fifth year), by clinical index including symptom and rescue medication scores (SMS), visual analog scale (VAS), total immunoglobulin E (tIgE), and specific IgE (sIgE). Asthma was assessed by clinical evaluation.ResultsThe decrease of SMS and VAS from baseline was significantly improved in the SIT group compared with controls at both the third and fifth year. For patients without asthma at baseline, the odds ratio for no asthma was 3.57 (95% confidence interval, 1.05‐12.91; P <. 05) in favor of SIT. The serum sIgE/tIgE ratio was significantly increased after SIT treatment in the SIT group, but it was not related to SIT efficacy.ConclusionSIT has a long‐term effect of improving clinical symptoms and reducing the risk of development of asthma in Chinese AR patients.
Intraoperative Use of FloSeal with Adenotonsillectomy to Prevent Adverse Postoperative Outcomes in Pediatric Patients
Authors: Dyer Steven R. , Bathula Samba , Durvasula Phani , Madgy David , Haupert Michael , Dworkin James , Sana Saidshoib 
Published: April 2013

ObjectiveThe purpose of this study was to compare postoperative complications associated with monopolar dissection adenotonsillectomy, with and without the application of FloSeal at the completion of the procedure.Study DesignRetrospective cohort study.SettingTertiary care pediatric hospital.Subjects and MethodsThis was a retrospective cohort study of 800 cases of adenotonsillectomy. Two cohorts of patients were identified based on whether or not FloSeal was used intraoperatively during the completion of the monopolar dissection adenotonsillectomy. Outcomes that were measured included: (1) age, (2) sex, (3) diagnosis, (4) primary hemorrhage, (5) secondary hemorrhage, (6) return to operating room, and (7) dehydration. All binomial outcomes measured were subjected to chi‐square and t tests.ResultsAge and gender were similar between the 2 groups. Chronic tonsillitis was the primary indication more often in the control group; this was statistically significant. Primary hemorrhage occurred in 1 subject from each group (0.28%); secondary hemorrhage occurred in 11 subjects from the FloSeal group (3.22%) and 7 from the control group (1.87%). Both outcomes were not statistically different between the 2 groups. Return to operating room showed no statistically significant difference between groups. The need for postoperative admission for dehydration failed to show statistical significance between groups.ConclusionIn our experience, the application of FloSeal hemostatic matrix after monopolar adenotonsillectomy demonstrates no additional reduction in postoperative adverse events encountered in the pediatric population. Specifically, our data failed to demonstrate statistically significant reduction of: (1) primary hemorrhage, (2) secondary hemorrhage, (3) return to operating theatre, or (4) dehydration.
PARP1 is required for chromosomal translocations
Authors: Wray Justin , Williamson Elizabeth A. , Singh Sudha B. , Wu Yuehan , Cogle Christopher R. , Weinstock David M. , Zhang Yu , Lee Suk-Hee , Zhou Daohong , Shao Lijian , Hauer-Jensen Martin , Pathak Rupak , Klimek Virginia , Nickoloff Jac A. , Hromas Robert 
Published: April 2013

Key Points
Chromosomal translocations are mediated by PARP1 and can be suppressed by the clinical PARP1 inhibitors.
SF3B1 mutations in chronic lymphocytic leukemia
Authors: Wan Youzhong , Wu Catherine J. 
Published: April 2013

Abstract
SF3B1 is a critical component of the splicing machinery, which catalyzes the removal of introns from precursor messenger RNA (mRNA). Next-generation sequencing studies have identified mutations in SF3B1 in chronic lymphocytic leukemia (CLL) at high frequency. In CLL, SF3B1 mutation is associated with more aggressive disease and shorter survival, and recent studies suggest that it can be incorporated into prognostic schema to improve the prediction of disease progression. Mutations in SF3B1 are predominantly subclonal genetic events in CLL, and hence are likely later events in the progression of CLL. Evidence of altered pre-mRNA splicing has been detected in CLL cases with SF3B1 mutations. Although the causative link between SF3B1 mutation and CLL pathogenesis remains unclear, several lines of evidence suggest SF3B1 mutation might be linked to genomic stability and epigenetic modification.
BioNLP Shared Task - The Bacteria Track
Authors: Bossy Robert , Jourde Julien , Manine Alain-Pierre , Veber Philippe , Alphonse Erick , van de Guchte Maarten , Bessières Philippe , Nédellec Claire 
Published: April 2013

Abstract

Background
We present the BioNLP 2011 Shared Task Bacteria Track, the first Information Extraction challenge entirely dedicated to bacteria. It includes three tasks that cover different levels of biological knowledge. The Bacteria Gene Renaming supporting task is aimed at extracting gene renaming and gene name synonymy in PubMed abstracts. The Bacteria Gene Interaction is a gene/protein interaction extraction task from individual sentences. The interactions have been categorized into ten different sub-types, thus giving a detailed account of genetic regulations at the molecular level. Finally, the Bacteria Biotopes task focuses on the localization and environment of bacteria mentioned in textbook articles.
We describe the process of creation for the three corpora, including document acquisition and manual annotation, as well as the metrics used to evaluate the participants' submissions.

Results
Three teams submitted to the Bacteria Gene Renaming task; the best team achieved an F-score of 87%. For the Bacteria Gene Interaction task, the only participant's score had reached a global F-score of 77%, although the system efficiency varies significantly from one sub-type to another. Three teams submitted to the Bacteria Biotopes task with very different approaches; the best team achieved an F-score of 45%. However, the detailed study of the participating systems efficiency reveals the strengths and weaknesses of each participating system.

Conclusions
The three tasks of the Bacteria Track offer participants a chance to address a wide range of issues in Information Extraction, including entity recognition, semantic typing and coreference resolution. We found commond trends in the most efficient systems: the systematic use of syntactic dependencies and machine learning. Nevertheless, the originality of the Bacteria Biotopes task encouraged the use of interesting novel methods and techniques, such as term compositionality, scopes wider than the sentence.
TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aeruginosa
Authors: Neidig Anke , Yeung Amy TY , Rosay Thibaut , Tettmann Beatrix , Strempel Nikola , Rueger Martina , Lesouhaitier Olivier , Overhage Joerg 
Published: April 2013

AbstractBackgroundPseudomonas aeruginosais an important opportunistic human pathogen and is extremely difficult to treat due to its high intrinsic and adaptive antibiotic resistance, ability to form biofilms in chronic infections and broad arsenal of virulence factors, which are finely regulated. TypA is a GTPase that has recently been identified to modulate virulence in enteric Gram-negative pathogens.ResultsHere, we demonstrate that mutation oftypAinP. aeruginosaresulted in reduced virulence in phagocytic amoebae and human macrophage models of infection. In addition, thetypAmutant was attenuated in rapid cell attachment to surfaces and biofilm formation, and exhibited reduced antibiotic resistance to ß-lactam, tetracycline and antimicrobial peptide antibiotics. Quantitative RT-PCR revealed the down-regulation, in atypAmutant, of important virulence-related genes such as those involved in regulation and assembly of the Type III secretion system, consistent with the observed phenotypes and role in virulence ofP. aeruginosa.ConclusionsThese data suggest that TypA is a newly identified modulator of pathogenesis inP. aeruginosaand is involved in multiple virulence-related characteristics.
Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies
Authors: Titova Olga E , Hjorth Olof C , Schiöth Helgi B , Brooks Samantha J 
Published: April 2013

Abstract

Background
Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done.

Methods
In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using global and regional analyses.

Results
Anorexia nervosa (AN) patients have global reductions in gray (effect size = −0.66) and white matter (effect size = −0.74) and increased cerebrospinal fluid (effect size = 0.98) and have regional decreases in left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate, and no significant increases. No significant difference in hemispheric lateralization was found.

Conclusions
Global and regional meta-analyses suggest that excessive restrained eating as found in those with anorexia nervosa coincides with structural brain changes analogous to clinical symptoms.