bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of meningitis with a negative CSF Gram stain: under-utilization of available diagnostic tests
Authors: NESHER L. , HADI C. M. , SALAZAR L. , WOOTTON S. H. , GAREY K. W. , LASCO T. , LUCE A. M. , HASBUN R. 
Published: May 2015

SUMMARYMeningitis with a negative cerebrospinal fluid Gram stain (CSF-GS) poses a diagnostic challenge as more than 50% of patients remain without an aetiology. The introduction of polymerase chain reaction (PCR) and arboviral serologies have increased diagnostic capabilities, yet large scale epidemiological studies evaluating their use in clinical practice are lacking. We conducted a prospective observational study in New Orleans between November 1999 and September 2008 (early era) when PCR was not widely available, and in Houston between November 2008 and June 2013 (modern era), when PCR was commonly used. Patients presenting with meningitis and negative CSF-GS were followed for 4 weeks. All investigations, PCR used, and results were recorded as they became available. In 323 patients enrolled, PCR provided the highest diagnostic yield (24·2%) but was ordered for 128 (39·6%) patients; followed by serology for arboviruses (15%) that was ordered for 100 (31%) of all patients. The yield of blood cultures was (10·3%) and that of CSF cultures was 4%; the yield for all other tests was <10%. Overall, 65% of the patients remained without a diagnosis at 4 weeks: 72·1% in early era vs. 53·4% (P < 0·01) in modern era; this change was attributed to diagnosing more viral pathogens, 8·3% and 26·3% (P < 0·01), respectively. The introduction of PCR and arboviral serologies has improved the yield of diagnosing patients with meningitis and a negative CSF-GS, but both tests are being under-utilized.
Review of paediatric cardiology services in district general hospitals in the United Kingdom
Authors: Andrews Hannah , Singh Yogen 
Published: May 2015

AbstractFollowing the Safe and Sustainable review of Paediatric Services in 2012/2013, National Health Service England recommended that local paediatric cardiology services should be provided by specially trained paediatricians with expertise in cardiology in all non-specialist hospitals.AimTo understand the variation in local paediatric cardiology services provided across district general hospitals in the United Kingdom.Study design and methodsAn internet-based questionnaire was sent out via the Paediatrician with Expertise in Cardiology Special Interest Group and the Neonatologists with Interest in Cardiology and Haemodynamics contact databases and the National Health Service directory. Non-responders were followed-up via telephone.ResultsThe response rate was 80% (141 of 177 hospitals), and paediatricians with expertise in cardiology were available in 68% of those. Local cardiology clinics led by paediatricians with expertise in cardiology were provided in 96 hospitals (68%), whereas specialist outreach clinics were held in 123 centres (87%). A total of 11 hospitals provided neither specialist outreach clinics nor any local cardiology clinics led by paediatricians with expertise in cardiology. Paediatric echocardiography services were provided in 83% of the hospitals, 12-lead electrocardiogram in 96%, Holter electrocardiogram in 91%, and exercise testing in only 47% of the responding hospitals. Telemedicine facilities were established in only 52% of the centres, where sharing echocardiogram images via picture archiving and communication system was used most commonly.ConclusionThere has been a substantial increase in the availability of paediatricians with expertise in cardiology since 2008. Most of the hospitals are well-supported by specialist cardiology centres via outreach clinics; however, there remains significant variation in the local paediatric cardiology services provided across district general hospitals in the United Kingdom.
Relationship of Contextual Cueing and Hippocampal Volume in Amnestic Mild Cognitive Impairment Patients and Cognitively Normal Older Adults
Authors: Negash Selam , Kliot Daria , Howard Darlene V. , Howard James H. , Das Sandhistu R. , Yushkevich Paul A. , Pluta John B. , Arnold Steven E. , Wolk David A. 
Published: May 2015

AbstractThere is currently some debate as to whether hippocampus mediates contextual cueing. In the present study, we examined contextual cueing in patients diagnosed with mild cognitive impairment (MCI) and healthy older adults, with the main goal of investigating the role of hippocampus in this form of learning. Amnestic MCI (aMCI) patients and healthy controls completed the contextual cueing task, in which they were asked to search for a target (a horizontal T) in an array of distractors (rotated L’s). Unbeknownst to them, the spatial arrangement of elements on some displays was repeated thus making the configuration a contextual cue to the location of the target. In contrast, the configuration for novel displays was generated randomly on each trial. The difference in response times between repeated and novel configurations served as a measure of contextual learning. aMCI patients, as a group, were able to learn spatial contextual cues as well as healthy older adults. However, better learning on this task was associated with higher hippocampal volume, particularly in right hemisphere. Furthermore, contextual cueing performance was significantly associated with hippocampal volume, even after controlling for age and MCI status. These findings support the role of the hippocampus in learning of spatial contexts, and also suggest that the contextual cueing paradigm can be useful in detecting neuropathological changes associated with the hippocampus. (JINS, 2015, 21, 285–296)
Health effects of cow’s milk consumption in infants up to 3 years of age: a systematic review and meta-analysis
Authors: Griebler Ursula , Bruckmüller Melanie U , Kien Christina , Dieminger Birgit , Meidlinger Bettina , Seper Katrin , Hitthaller Ariane , Emprechtinger Robert , Wolf Alexandra , Gartlehner Gerald 
Published: May 2015

AbstractObjectiveTo summarize the best available evidence regarding the short- and long-term health effects of cow’s milk intake in healthy, full-term infants up to 3 years of age.DesignWe conducted a systematic review and meta-analysis.SettingWe searched MEDLINE (via PubMed), EMBASE and the Cochrane Library between 1960 and July 2013 and manually reviewed reference lists of pertinent articles. Two researchers independently reviewed abstracts and full-text articles and extracted relevant data.SubjectsWe included (randomized/non-randomized) controlled trials and observational studies.ResultsWe included data from twenty-three studies (one randomized controlled trial, four non-randomized controlled trials, eight case–control studies and ten cohort studies) for the evidence synthesis. Pooled results of four studies revealed a higher risk of Fe-deficiency anaemia for infants consuming cow’s milk compared with those consuming follow-on formula (relative risk=3·76; 95 % CI 2·73, 5·19). For type 1 diabetes mellitus, six out of seven case–control studies did not show a difference in the risk of developing this disease based on the age of introduction of cow’s milk. We did not find negative associations for other health effects.ConclusionsCow’s milk consumption in infancy is associated with an increased risk of developing Fe-deficiency anaemia. Limiting cow’s milk consumption may be important to ensure an adequate Fe intake for infants and toddlers. High-quality patient information for caregivers is needed on how infants’ Fe requirements can be met.
The association between socio-economic position and diet quality in Australian adults
Authors: Backholer Kathryn , Spencer Elizabeth , Gearon Emma , Magliano Dianna J , McNaughton Sarah A , Shaw Jonathan E , Peeters Anna 
Published: May 2015

AbstractObjectiveWe aimed to investigate the association between multiple measures of socio-economic position (SEP) and diet quality, using a diet quality index representing current national dietary guidelines, in the Australian adult population.DesignCross-sectional study. Linear regression analyses were used to estimate the association between indicators of SEP (educational attainment, level of income and area-level disadvantage) and diet quality (measured using the Dietary Guideline Index (DGI)) in the total sample and stratified by sex and age (≤55 years and >55 years).SettingA large randomly selected sample of the Australian adult population.SubjectsAustralian adults (n 9296; aged ≥25 years) from the Australian Diabetes, Obesity and Lifestyle Study.ResultsA higher level of educational attainment and income and a lower level of area-level disadvantage were significantly associated with a higher DGI score, across the gradient of SEP. The association between indicators of SEP and DGI score was consistently stronger among those aged ≤55 years compared with their older counterparts. The most disadvantaged group had a DGI score between 2 and 5 units lower (depending on the marker of SEP) compared with the group with the least disadvantage.ConclusionsA higher level of SEP was consistently associated with a higher level of diet quality for all indicators of SEP examined. In order to reduce socio-economic inequalities in diet quality, healthy eating initiatives need to act across the gradient of socio-economic disadvantage with a proportionate focus on those with greater socio-economic disadvantage.
A mixed-methods exploration of implementation of a comprehensive school healthy eating model one year after scale-up
Authors: Naylor Patti-Jean , McKay Heather A , Valente Maria , Mâsse Louise C 
Published: May 2015

AbstractObjectiveTo study the implementation of a school-based healthy eating (HE) model one year after scale-up in British Columbia (BC). Specifically, to examine implementation of Action Schools! BC (AS! BC) and its influence on implementation of classroom HE activities, and to explore factors associated with implementation.DesignDiffusion of Innovations, Social Cognitive and Organizational Change theories guided our approach. We used a mixed-methods research design including focus group interviews (seven schools, sixty-two implementers) and a cross-sectional multistage survey to principals (n36, 92 % response rate) and teachers of grades 4 to 7 (n168, 70 % response rate). Self-reported implementation of classroom HE activities and reported use of specific AS! BC HE activities were primary implementation measures. Thematic analysis of focus group data and multilevel mixed-effect logistic regression analyses of survey data were conducted.SettingElementary schools across BC, Canada.SubjectsThirty-nine school districts, thirty-six principals, 168 grade 4 to 7 teachers.ResultsForty-two per cent of teachers in registered schools were implementing AS! BC HE in their classrooms. Users were 6·25 times more likely to have delivered a HE lesson in the past week. Implementation facilitators were school champions, technical support and access to resources; barriers were lack of time, loss of leadership or momentum. Implementation predictors were teacher training, self-efficacy, experience with the physical activity component of AS! BC, supportive school climate and parental post-secondary education.ConclusionsOur findings reinforce that continued teacher training and support are important public health investments that contribute to successful implementation of school-based HE models after scale-up.
High cardiometabolic risk in healthy Chilean adolescents: associations with anthropometric, biological and lifestyle factors
Authors: Burrows Raquel , Correa-Burrows Paulina , Reyes Marcela , Blanco Estela , Albala Cecilia , Gahagan Sheila 
Published: May 2015

AbstractObjectiveTo analyse the prevalence of cardiovascular risk factors in healthy adolescents of low to middle socio-economic status and to study the influence of anthropometric, biological and lifestyle factors on the risk of metabolic syndrome (MetS).DesignCross-sectional study. BMI, waist circumference, blood pressure, fat and lean mass (by dual-energy X-ray absorptiometry), TAG, HDL-cholesterol, glucose, insulin, homeostatic model assessment–insulin resistance index (HOMA-IR), food intake and physical activity were measured. Cardiovascular risk factors were defined using the International Diabetes Federation criteria and insulin resistance using HOMA-IR ≥2·6. Bivariate and multivariate regressions examined the associations between MetS and anthropometric, biological and lifestyle factors.SettingObservational cohort study including Chilean adolescents, who were part of a follow-up study beginning in infancy.SubjectsAdolescents aged 16–17 years (n667).ResultsIn the sample, 16·2 % had obesity and 9·5 % had MetS. Low HDL-cholesterol (69·9 %), abdominal obesity (33·3 %) and fasting hyperglycaemia (8·7 %) were the most prevalent cardiovascular risk factors. In males, obesity (OR=3·7; 95 % CI 1·2, 10·8), insulin resistance (OR=3·0; 95 % CI 1·1, 8·2), physical inactivity (OR=2·9; 95 % CI 1·1, 7·7) and sarcopenia (OR=21·2; 95 % CI 4·2, 107·5) significantly increased the risk of MetS. In females, insulin resistance (OR=4·9; 95 % CI 1·9, 12·6) and sarcopenia (OR=3·6; 95 % CI 1·1, 11·9) were significantly associated with MetS.ConclusionsHigh prevalences of obesity, abdominal obesity, dyslipidaemia, fasting hyperglycaemia and MetS were found in healthy adolescents. In both sexes, sarcopenia and insulin resistance were important risk factors of MetS. Promotion of active lifestyles at the school level and regulation of the sale of energy-dense foods are needed.
Reducing salt in bread: a quasi-experimental feasibility study in a bakery in Lima, Peru
Authors: Saavedra-Garcia Lorena , Sosa-Zevallos Vanessa , Diez-Canseco Francisco , Miranda J Jaime , Bernabe-Ortiz Antonio 
Published: May 2015

AbstractObjectivesTo explore salt content in bread and to evaluate the feasibility of reducing salt contained in ‘pan francés’ bread.DesignThe study had two phases. Phase 1, an exploratory phase, involved the estimation of salt contained in bread as well as a triangle taste test to establish the amount of salt to be reduced in ‘pan francés’ bread without detection by consumers. In Phase 2, a quasi-experimental, pre–post intervention study assessed the effects of the introduction of low-salt bread on bakery sales.SettingA municipal bakery in Miraflores, Lima, Peru.SubjectsSixty-five clients of the bakery in Phase 1 of the study; sales to usual costumers in Phase 2.ResultsOn average, there was 1·25 g of salt per 100 g of bread. Sixty-five consumers were enrolled in the triangle taste test: fifty-four (83·1 %) females, mean age 58·9 (sd 13·7) years. Based on taste, bread samples prepared with salt reductions of 10 % (P=0·82) and 20 % (P=0·37) were not discernible from regular bread. The introduction of bread with 20 % of salt reduction, which contained 1 g of salt per 100 g of bread, did not change sales of ‘pan francés’ (P=0·70) or other types of bread (P=0·36). Results were consistent when using different statistical techniques.ConclusionsThe introduction of bread with a 20 % reduction in salt is feasible without affecting taste or bakery sales. Results suggest that these interventions are easily implementable, with the potential to contribute to larger sodium reduction strategies impacting the population’s cardiovascular health.
Characterization of Nanoporous Materials with Atom Probe Tomography
Authors: Pfeiffer Björn , Erichsen Torben , Epler Eike , Volkert Cynthia A. , Trompenaars Piet , Nowak Carsten 
Published: May 2015

AbstractA method to characterize open-cell nanoporous materials with atom probe tomography (APT) has been developed. For this, open-cell nanoporous gold with pore diameters of around 50 nm was used as a model system, and filled by electron beam-induced deposition (EBID) to obtain a compact material. Two different EBID precursors were successfully tested—dicobalt octacarbonyl [Co2(CO)8] and diiron nonacarbonyl [Fe2(CO)9]. Penetration and filling depth are sufficient for focused ion beam-based APT sample preparation. With this approach, stable APT analysis of the nanoporous material can be performed. Reconstruction reveals the composition of the deposited precursor and the nanoporous material, as well as chemical information of the interfaces between them. Thus, it is shown that, using an appropriate EBID process, local chemical information in three dimensions with sub-nanometer resolution can be obtained from nanoporous materials using APT.
High Vertical Resolution Full-Field Reflection-Type Three-Dimensional Angle-Deviation Microscope with Nonlinear Error Compensation
Authors: Chiu Ming-Hung , Tan Chen-Tai , Huang Shih-Feng , Chen Jhao-An 
Published: May 2015

AbstractThis study examines the use of reflectivity-height transformation in full-field angle-deviation microscopes (ADM). In such microscopes, two light intensity distribution images of a prism’s total internal reflection and critical angle are obtained separately with two charge-coupled devices (CCDs), and are converted into a reflectivity profile point-to-point and then into angle of deviation matrix after the beam is reflected by the test sample; finally, the surface height of the sample is found through the triangular geometrical relationship. This method obtains the image through the effective imaging area of CCD. Once the two-dimensional (2D) image is obtained, the third dimension, height, is added to create a full-field 3D surface profile. Its conversion process is nonlinear; therefore, compensation must be made to reduce measurement errors. The optical magnification of high vertical resolution full-field 3D reflection-type ADM could reach >250 times, thus providing submicron measurements with nanometer vertical resolution and allowing for the simultaneous measurement of 2D and 3D images. Small defects on both transparent and nontransparent surfaces can be rapidly detected.
Upper limits on the probability of an interstellar civilization arising in the local Solar neighbourhood
Authors: Cartin Daniel 
Published: May 2015

AbstractAt this point in time, there is very little empirical evidence on the likelihood of a space-faring species originating in the biosphere of a habitable world. However, there is a tension between the expectation that such a probability is relatively high (given our own origins on Earth), and the lack of any basis for believing the Solar System has ever been visited by an extraterrestrial colonization effort. From the latter observational fact, this paper seeks to place upper limits on the probability of an interstellar civilization arising on a habitable planet in its stellar system, using a percolation model to simulate the progress of such a hypothetical civilization's colonization efforts in the local Solar neighbourhood. To be as realistic as possible, the actual physical positions and characteristics of all stars within 40 parsecs of the Solar System are used as possible colony sites in the percolation process. If an interstellar civilization is very likely to have such colonization programmes, and they can travel over large distances, then the upper bound on the likelihood of such a species arising per habitable world is of the order of 10−3; on the other hand, if civilizations are not prone to colonize their neighbours, or do not travel very far, then the upper limiting probability is much larger, even of order one.
W. E. B. DU BOIS AND THE CRITIQUE OF THE COMPETITIVE SOCIETY
Authors: Douglas Andrew J. 
Published: May 2015

AbstractThis essay explores W. E. B. Du Bois’s evolving sense of disillusionment with the liberal paradigm in an effort to stimulate critical thinking about an American political culture consumed by both the fear and purported legitimacy of private competition. Du Bois always encouraged sustained critical appraisal of an American society torn between winners and losers, the favored and the damned. As his thinking developed into the 1930s, he focused more squarely upon the logic of capital accumulation, or the structural imperative to expand power in the service of private interest, and always in response to a suspicion or fear of the other—the competitor. I suggest that Du Bois’s claims about the racially biased character of the competitive society, as well as his argument, put forth in a series of speeches and writings on “Negro education,” that Black colleges ought to facilitate the critique of this society, may have some normative import today as widespread, often unreflective acquiescence to the principles of competitive liberalism seems poised to exacerbate and further legitimize racial and economic inequities.
EVERYDAY POLITICS OF SCHOOL CHOICE IN THE BLACK COMMUNITY
Authors: Pattillo Mary 
Published: May 2015

AbstractSchool choice is promoted as one strategy to improve educational outcomes for African Americans. Key themes in Black school choice politics are empowerment, control, and agency. Using qualitative interviews with seventy-seven poor and working-class Black parents in Chicago, this article asks: How well do the themes of empowerment, agency, and control characterize the experiences of low-income African American parents tasked with putting their children in schools? Also, what kind of political positions emerge from parents’ everyday experiences given the ubiquitous language of school choice? I find that in their own recounting parents focused on finding a quality school while experiencing numerous barriers to accessing such schools; parents expressed experiential knowledge of being chosen, rather than choosing; and parents highlighted the opacity, uncertainty, and burden of choice, even when they participated in it quite heartily. I argue that their stories convey limited and weak empowerment, limited individual agency, and no control. Their perspectives conjure policy frameworks and political ideologies that require a discussion of entitlements and provision, rather than choice.
RACIAL INEQUALITIES IN CONNECTEDNESS TO IMPRISONED INDIVIDUALS IN THE UNITED STATES
Authors: Lee Hedwig , McCormick Tyler , Hicken Margaret T. , Wildeman Christopher 
Published: May 2015

AbstractIn just the last forty years, imprisonment has been transformed from an event experienced by only the most marginalized to a common stage in the life course of American men—especially Black men with low levels of educational attainment. Although much research considers the causes of the prison boom and how the massive uptick in imprisonment has shaped crime rates and the life course of the men who experience imprisonment, in recent years, researchers have gained a keen interest in the spillover effects of mass imprisonment on families, children, and neighborhoods. Unfortunately, although this new wave of research documents the generally harmful effects of having a family member or loved one incarcerated, it remains unclear how much the prison boom shapes social inequality through these spillover effects because we lack precise estimates of the racial inequality in connectedness—through friends, family, and neighbors—to prisoners. Using the 2006 General Social Survey, we fill this pressing research gap by providing national estimates of connectedness to prisoners—defined in this article as knowing someone who is currently imprisoned, having a family member who is currently imprisoned, having someone you trust who is currently imprisoned, or having someone you know from your neighborhood who is currently imprisoned—for Black and White men and women. Most provocatively, we show that 44% of Black women (and 32% of Black men) but only 12% of White women (and 6% of White men) have a family member imprisoned. This means that about one in four women in the United States currently has a family member in prison. Given these high rates of connectedness to prisoners and the vast racial inequality in them, it is likely that mass imprisonment has fundamentally reshaped inequality not only for the adult men for whom imprisonment has become common, but also for their friends and families.