bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization of HAMP rs10421768 gene and phenotypic expression of hepcidin; a case-control study among sickle cell anaemia patients in Ghana
Authors: Appiah Samuel Kwasi , Nkansah Charles , Abbam Gabriel , Osei-Boakye Felix , Mensah Kofi , Bani Simon Bannison , Chemogo Solomon , Sarpong Lydia , Addae Takyi Godfred , Sefa Daniel Boamah , Croffien Richard Adu , Adom Larry , Rauf Rekhiatu Oboirien Abdul , Boadu Farrid , Amoah Godfred Appiah , Chukwurah Ejike Felix 
Published: June 2024

Background
The sporadic nature of blood transfusion therapy coupled with the alteration of HAMP genes may exacerbate the risk of iron burden in sickle cell anaemia (SCA) patients. The study determined the polymorphic distribution of the HAMP promoter gene rs10421768 and hepcidin levels in SCA patients.

Method
Sixty participants aged ≥12years [45 SCA patients and 15 controls (HbA)] were recruited from 15th March, 2023 to 20th July, 2023 for a case-control study at Methodist Hospital Wenchi, Ghana. Complete blood count and hepcidin levels assessment were done using haematology analyzer and ELISA, respectively. Genomic DNA was extracted using the Qiagen Kit, and HAMP gene rs10421768 (c.-582 A>G) was sequenced using the MassARRAY method. Data were analysed using SPSS version 26.0.

Results
The frequencies of the HAMP promoter rs10421768 genotypes AA, AG, and GG were 64.4%, 33.3%, and 2.2% in SCA patients, and 86.7%, 13.3%, and 0% in the controls, respectively. Serum hepcidin levels were significantly higher among controls than cases [204.0 (154.1–219.3) vs 150.2 (108.1–195.6)μg/L, p<0.010]. Participants with HAMP rs10421768 homozygous A genotype had higher serum levels of hepcidin compared with those in the wild genotypes (AG/GG) group [(188.7 (130.9–226.9) vs 136.8 (109.7–157.8)μg/L, p<0.016]. Disease severity and blood cell parameters were not associated with the HAMP variants (p>0.05).

Conclusion
The HAMP promoter rs10421768 AA genotype has the highest frequency of distribution and the GG genotype with the least distribution. Participants with HAMP rs10421768 G allele (c.-582A>G) had reduced levels of hepcidin. HAMP rs10421768 genotypes had no association with blood cell parameters and disease severity. The HAMP rs10421768 genotypes may influence serum levels of hepcidin. Further study is required to elucidate the potential effect of the G allele on hepcidin transcription.
Evaluation of the role of some non-enzymatic antioxidants among Iraqi patients with non-alcoholic fatty liver disease
Authors: Hussein Ammar L. , Nema Dunia T. , Nasir Gulboy A. 
Published: June 2024

Abstract
Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic fat accumulation in individuals consuming little or no alcohol, has become highly prevalent globally. Oxidative stress plays a central role in instigating inflammation and cell death pathways driving NAFLD progression. This case–control study aimed to elucidate the association between circulating levels of the pivotal non-enzymatic antioxidants – coenzyme Q10 and vitamins E and C – and liver injury parameters among 60 Iraqi NAFLD patients versus 30 healthy controls. NAFLD diagnosis entailed over 5% hepatic steatosis on ultrasound excluding other etiologies. Patients spanned three age groups: 20–29, 30–39, and 40–49. Substantially diminished antioxidant levels concurrent with elevated alkaline phosphatase enzyme were unveiled in NAFLD patients relative to controls (all p < 0.001). Age-based analysis reinforced widespread antioxidant depletion and liver enzyme augmentation across NAFLD patients. Significant correlations also emerged between antioxidants and liver parameters. Our novel observations confirm an antioxidant inadequacy likely perpetuating pathogenic oxidative reactions in NAFLD. Restoring such deficits through lifestyle or therapeutic interventions may confer preventative and disease-modifying value.
The role of Phafin proteins in cell signaling pathways and diseases
Authors: Tang Tuoxian , Sun Jing , Li Chen 
Published: June 2024

Abstract
Membrane-associated proteins are important membrane readers that mediate and facilitate the signaling and trafficking pathways in eukaryotic membrane-bound compartments. The protein members in the Phafin family are membrane readers containing two phosphoinositide recognition domains: the Pleckstrin Homology domain and the FYVE (Fab1, YOTB, Vac1, and early endosome antigen 1) domain. Phafin proteins, categorized into two subfamilies, Phafin1 and Phafin2, associate with cellular membranes through interactions involving membrane-embedded phosphoinositides and phosphoinositide-binding domains. These membrane-associated Phafin proteins play pivotal roles by recruiting binding partners and forming complexes, which contribute significantly to apoptotic, autophagic, and macropinocytotic pathways. Elevated expression levels of Phafin1 and Phafin2 are observed in various cancers. A recent study highlights a significant increase in Phafin1 protein levels in the lungs of idiopathic pulmonary fibrosis patients compared to normal subjects, suggesting a crucial role for Phafin1 in the pathogenesis of pulmonary fibrosis. Additionally, phosphatidylinositol-3-phosphate-binding 2 (Pib2), a close relative of the Phafin1 protein, functions as an amino acid sensor activating the TOCR1 pathway in yeasts. This review focuses on delineating the involvement of Phafin proteins in cellular signaling and their implications in diseases and briefly discusses the latest research findings concerning Pib2.
Из истории термина «футуризм» в литературно-художественной жизни России и СССР первой трети ХХ века
Authors: Крусанов Андрей Васильевич 
Published: June 2024

Аннотация
В статье рассмотрены смысловые изменения терминов «футуризм» и «футуристы» в художественной жизни России первой трети ХХ века, а также влияние общественной и социально-политической обстановки на их восприятие. Термин «футуризм» приобрел в России различные толкования, подчас далекие от эстетики и художественной программы итальянских футуристов. В то же время разрушительная тенденция, выраженная в эстетике и практике итальянского и российского футуризмов, соответствовала социально-политическим стремлениям социалистов к ниспровержению существующего строя, но выражалась языком искусства и применялась не к социуму, а к его изображению в живописи и литературе. При этом поиски новых форм общественной жизни сопровождались поиском новых форм живописного и словесного изображения. Переход к мирному строительству в начале 1920-х гг. привел в общественной жизни к смене разрушительной тенденции на созидательную, а в искусстве – к распаду футуризма и замене его конструктивизмом.
Examining the dual effect of copper nanoparticles and nitrogen doping on Cu@N-TiO2
Authors: Rátiva-Parada Wilson , Gómez-Cuaspud Jairo A. , Cerón-Achicanoy María A. , Vera-López Enrique , Carda-Castelló Juan B. 
Published: June 2024

Abstract
The study of six compositions of Cu@N-TiO2 with different amounts of copper and nitrogen synthesized using a sol–gel method is reported. X-ray diffraction patterns and Raman spectra indicated the formation of a single anatase TiO2 phase in all materials without evidence of secondary phases including copper or nitrogen. Electron microscopy images showed a homogeneous distribution of the copper particles around a TiO2 matrix, just as that the insertion of nitrogen did not have a significant effect on the morphology of the particles. X-ray photoelectron spectroscopy analysis confirmed that nitrogen was inserted in the atomic arrangement of titanium dioxide, while copper was presented mainly as metallic element on the TiO2 surface. Characterization of the optical properties and photoactivity test confirm that band gap strongly depends on the copper and nitrogen content phenomenon attributed to the combined presence of modifiers over the TiO2 surface and the promotion of a plasmonic effect, which displaced the absorption UV bands to higher wavelengths with respect to un-doped TiO2. The catalytic test performed using rhodamine-B as probe molecule, confirm that TiCuN2 and TiCuN3 samples exhibit the best decomposition percentages of 38 and 36 % respectively. Such results confirm the surface plasmon resonance effect associated to Cu particles on the TiO2 as main cause in the increase in current along synthesized samples and the use of cyclic voltammetry technique to identify these effects between 0.0 and 1.5 V.
Transparent poly(methyl methacrylate-butyl acrylate-hexafluorobutyl methacrylate) for conservation of stone relics: synthesis and test
Authors: Ma Chuang , Chin Sim Yee , Zhang Yue , Ghazali Suriati B. , Zhang Hengqiang 
Published: June 2024

Abstract
A transparent poly(methyl methacrylate-butyl acrylate-hexafluorobutyl methacrylate) stone relics protective material was synthesized using one-pot method. The synthesized polymer was coated on the surface of the stone samples or glass plates. SEM was used to observe the micromorphology of pristine stone and stone covered polymer coating samples. Physical properties of polymer coatings were characterized by FTIR, XRD and TGA-DSC. The conservation properties of polymer coatings were investigated by testing adhesion, transparency, hydrophobicity, mass loss rate and appearance of the simulated stone relics after freeze–thaw, UV irradiation and acid aging processes. Results show that poly (MMA-BA-20.04 %HFMA) outperformed the others with water contact angle remained 108.23°, 109.34° and 106.96° as well as the change of chromaticity difference values of 0.79, 0.02 and 0.08, after freeze-thaw, UV-aging and acid-aging processes, respectively. All these data indicate that the as-synthesized polymer could potentially use in conservating the stone relics due to its superior hydrophobicity, transparency, anti-acid and anti-UV aging properties as well as durability for freeze–thaw.
Recent advances in carbon quantum dots for antibiotics detection
Authors: Ding Guojun , Yan Fanyong , Yang Shangpeng , Fu Yang 
Published: June 2024

Abstract
A great deal of attention has been pressed to the hazards caused by the remains of antibiotics in the environment. Fluorescent sensing materials are favored for their rapid qualitative and quantitative detection of antibiotics, with carbon quantum dots (CQDs) being widely used as typical fluorescent materials. CQDs have demonstrated superior performances in conducting antibiotic diagnosis, which makes them a key tool for tackling antibiotic residues. This review article investigates recent advances in CQDs for the assessment and determination of antibiotics residues, involved antibiotic assay components are classified according to the assay mechanism as Static quenching effect (SQE), Dynamic quenching effect (DQE), Internal filtering effect (IFE), and Förster resonance energy transfer (FRET) quenching mechanisms. We hope to provide valuable guidelines for the preparation of high-quality probes as well as limited detection of antibiotics, so as to promote the advancement of CQDs in the antimicrobial field.
Medieval grammars as non-literary source for syntax: The Wiki format for terminological analyses
Authors: Cotticelli-Kurras Paola , Cotugno Francesca 
Published: June 2024

AbstractThis paper aims at presenting the Wiki database of a current project and has a distinctly computational signature. It is a fitting complement to years of work in the study of linguistic variation, of non-classical forms of Latin, but also the infinite possibilities offered by this field of study in terms of historical linguistics and database implementation. In the specific case, we will use the metalinguistic term constructio as an example of the analytical potential offered by the WikiMedia of the SiRe project Parts of speech meet Rhetorics: Searching for syntax in the continuity between the Middle Ages and the Modern Age.
Rules over words: Regulation of chatbots in the legal market and ethical considerations
Authors: Necz Daniel 
Published: June 2024

AbstractThe emergence and fast proliferation of chatbot solutions have reshaped how we interact with customer services, professionals and organizations providing advisory services. Law firms and legal professionals have also been affected by chatbots, which have become an integral part of the legal market. They are used for training, discovery, legal research and various other tasks by multinational law firms and sole practitioners alike.Besides their benefits, however, chatbot solutions also face a number of limitations and their use could raise both legal and ethical concerns. Unsupervised use of such solutions can lead to serious professional responsibility issues, while their use in certain cases, such as in cases involving acting as a defense counsel or advising on sensitive matters, can also raise ethical concerns, or endanger the trust in lawyers built by generations of legal professionals. The processing of certain data or confidential information can further raise privacy or confidentiality issues, especially with respect to the need for artificial intelligence (AI) based solutions to constantly rely on huge datasets.Bearing the above in mind, the regulation of chatbots in the legal market is certainly a complex topic with many challenges. In this paper, I provide an overview of the use of chatbots in the legal market, summarize the main concerns regarding their use (especially including professional liability, privacy and ethical concerns) and also highlight the main challenges concerning AI and chatbot regulation and the potential approaches regulators could follow to prevent or minimize risks associated with the unlawful or unethical use of technology and disperse unnecessary fears by also supporting technological development and by preserving the positive effects of the use of chatbots in the legal market.
Microencapsulation of flaxseed oil produced by sequential rotor stator homogenization and spray drying – Optimization of emulsion composition
Authors: Yakdhane Asma , Chaabane Donia , Yakdhane Eya , Molnár Máté András , Nath Arijit , Koris András 
Published: June 2024

AbstractMicroencapsulation of flaxseed oil (FO) has received lots of attention in the food and biopharmaceutical industries. To produce FO microcapsules, aqueous emulsions of FO with polymeric carbohydrates (maltodextrin (MD) with dextrose equivalent (DE) 19, gum Arabic (GA) and modified starch (MS)) were prepared by a rotor stator homogenization and subsequently, dehydration of emulsions were performed by spray drying (SD). The objective of this research was to study the effects of different combinations of polymeric carbohydrates with FO in emulsion to obtain maximum encapsulation efficiency (EE). A 3 factorials–3 levels Box–Behnken design was used for the optimization purpose. The maximum EE was achieved using 0.79 MD-GA ratio, 20.23% MS and 24.62% FO in emulsion. Microcapsules obtained by optimum condition had EE 77.68%, particle size (D32) 120.0 ± 0.43 μm, moisture content1.6 ± 0.13%, wettability 192 ± 5.5 s, solubility 75.49 ± 1.3%, bulk density 0.31 ± 0.025 g mL−1, tapped density 0.36 ± 0.01 g mL−1, Carr's Index 13.88 ± 0.01% and Hausner Ratio 1.16 ± 0.01.
La Chapelle and Massialot
Authors: Hyman Philip , Hyman Mary 
Published: June 2024

A number of important new cookery books appeared in France in the latter part of the 17th century. And a further cloudburst of new works rained down in the middle years of the 18th century. But from about 1695 until 1740 or so there was a curious lull. With only minor exceptions, all the new cookery books of this period were the work of two men, François Massialot and Vincent La Chapelle.
Massialot had in fact produced the first version of his book, which was originally called Le Cuisinier roial et bourgeois, in 1691 and it was reprinted on at least four occasions during the following fifteen years. But in 1712 he produced a changed and enlarged version called Le nouveau Cuisinier Royal et Bourgeois and this was again enlarged in 1730 and later. The enlargements were sufficiently considerable to warrant describing the later versions as new writing.
La Chapelle first published his work The Modern Cook (in English) in 1733. In 1735 he published both a French version (Le Cuisinier Moderne) and a reprint of the English version. A second French edition, with a new volume added, came out in 1742.
Thus these two writers dominated the field for some time; and they did so in sharp rivalry. Massialot accused LaChapelle of plagiarising him unscrupulously. La Chapelle rejected the charge outright and held up some of Massialot's recipes to ridicule. He invited anyone to compare the two rival works and stated his conviction that the result could only be a complete vindication of his own position.
One might have expected Massialot to take up the challenge. But he did not. It seems likely that he died or had died (the year of his death seems not to have been established with certainty) at the relevant time. And there is no sign, so far as we know, that the gage flung down by La Chapelle in 1742 has been taken up until now, 237 years later.
Philip and Mary Hyman, Americans who live in Paris and who have for years been studying the history of French cookery and French cookery writing, have, at long last, carried out the methodical comparison needed to establish the truth. We are glad to present here the rather startling results; and we hope that they will follow up this investigation by attempting, next year, a considered assessment of La Chapelle's work and of his reputation as an innovator in the history of French cooking.
Early Arab Cooking and Cookery Manuscripts
Authors: Roden Claudia 
Published: June 2024

Claudia Roden, author of A Book of Middle Eastern Food, was led in her researches for it to examine the surviving evidence about Arab cooking in the pre-Islamic period and the era of the Moslem Empire.
Learned articles by Professor A.J. Arberry and Professor Maxime Rodinson formed a basis on which she prepared a talk delivered to the Symposium on Cookery Books held at Saint Antony's College, Oxford, on 31 May 1980.
Professor Arberry's article 'A Baghdad Cookery Book', published in Islamic Culture 13 (1939) includes a translation of a manuscript cookery book of 1226.
In 1949 the eminent French orientalist Professor Maxime Rodinson published 'Recherches sur les Documents Arabes Relatifs ala Cuisine' in the Revue des Etudes Islamiques. In this sociological study of the history of food in the Arab world, he discusses early culinary literature, analyses cookery manuals and describes the court cuisine of the 12th and 13th centuries. Professor Rodinson later contributed to the first symposium of the 'Accademia Italiana Della Cucina,' in Venice in 1967, an essay on 'The Spice Trade and the Oriental influence on European Cooking'.
The novel perspectives revealed to Claudia Roden's audience at Oxford aroused great interest and a keen demand for 'the text'. However, like the early scribes whose work she cited, she had only a manuscript. The present essay is a slightly elaborated version of that manuscript. We print it in the belief that it is an important contribution to an area of research in which much work remains to be done - work which can be expected to cast fresh light on the origins of European cuisines of the Renaissance and later.
A holistic approach to acute pain in trauma: From assessment to intervention
Authors: Shetti Akshaya N 
Published: June 2024

Effective management of acute pain in trauma situations demands a comprehensive and holistic approach that encompasses various aspects ranging from initial assessment to intervention strategies. Meticulous assessment of pain severity, characteristics, and underlying etiology is essential for tailoring individualized treatment plans. This involves utilizing validated pain assessment tools, considering patient-reported pain scales, and integrating clinical judgment to accurately gauge pain intensity and quality.Subsequently, intervention strategies must be multifaceted, integrating pharmacological and non-pharmacological modalities to address pain effectively while minimizing adverse effects and promoting patient safety. Pharmacological interventions may include analgesics such as opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and adjuvant medications, administered judiciously based on pain severity and patient factors. Meanwhile, non-pharmacological approaches encompass techniques like regional anaesthesia, physical therapy, cognitive-behavioural therapy, and integrative therapies to augment pain relief and enhance overall well-being.
Economic assessment of convulsive status epilepticus: Investigating socioeconomic correlations in hospitalization costs and outcomes in Northern India
Authors: Ansari Ahmad Ghayas , Nasar Ariba , Nasar Hiba 
Published: June 2024

Convulsive Status Epilepticus (CSE) poses a considerable health challenge globally, especially in resource-limited regions like Northern India. Despite its medical implications, the economic impact of CSE remains understudied in these settings. This study aimed to evaluate the socio-economic impact of CSE by examining hospital costs and the financial strain experienced by patients in Northern India. Patients who presented with CSE were included in the study. Their demographic parameters, socioeconomic parameters and expenditure during the hospital stay were noted and outcome was assessed. Statistical analyses were conducted to identify associations between economic factors and clinical outcomes.The study comprised a total of 110 patients. Out of the total sample size of 110 individuals, 50.9% (n =56) were residents of rural areas, whereas 49.1% (n = 54) were from urban areas. A significant association with poor outcomes was observed between the education score of the family head (p=0.001), the Modified Kuppuswamy socio-economic class V (p=0.038) and the length of hospital stay (p=0.012). However, on performing a univariate logistic regression analysis to determine independent risk variables for poor outcome, it was observed that patients with an education status score of less than 4 (p=0.036, OR 65.405 95% CI 1.322 - 3235.454) and belonging to Modified Kuppuswamy socio-economic class IV or class V (p=0.045, OR 1.198 95% CI 1.013 - 1.305 and p=0.022, OR 2.156 95% CI 1.235 - 9.307 respectively) were significantly associated with poor outcome. The study underscores the substantial economic burden imposed by CSE on patients in Northern India, emphasizing the urgent need for targeted interventions to mitigate financial strain and enhance access to healthcare services.
SWOT of a Non-Communicable Diseases (NCD) care program in western India – lessons learned
Authors: Roy Kallol , Swati A Roy  , Amol R Dongre  
Published: June 2024

: Shree Krishna Hospital Program for Advancement of Rural and Social Health (SPARSH), it means “touch” in Hindi) aims to address the NCD burden through community-based service delivery.: We carried out SWOT analysis to understand the Strengths, Weaknesses, Opportunities, and Threats of SPARSH for further strategic planning.: Exploration of items for SWOT with staff was done. Salient items (items with more frequency) for each domain were selected to develop a five-point Likert type scale. Consensus score of each item was calculated and a score above 75% was considered salient.: Major strength was door to door medicine service & delivery worked. Weakness was communication gap while working in a large team. Staff felt that in era of emerging pandemics, NCD care must be strengthened and financial stability to run such a program was perceived as a threat.: SWOT explored the strengths which need to be strengthened. Weaknesses and opportunities to be addressed in future planning and program development.