bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient‐reported physical functioning predicts the success of hematopoietic cell transplantation (BMT CTN 0902)
Authors: Wood William A. , Le‐Rademacher Jennifer , Syrjala Karen L. , Jim Heather , Jacobsen Paul B. , Knight Jennifer M. , Abidi Muneer H. , Wingard John R. , Majhail Navneet S. , Geller Nancy L. , Rizzo J. Douglas , Fei Mingwei , Wu Juan , Horowitz Mary M. , Lee Stephanie J. 
Published: October 2015

BACKGROUNDIn hematopoietic cell transplantation (HCT), current risk adjustment strategies are based on clinical and disease‐related variables. Although patient‐reported outcomes (PROs) predict mortality in multiple cancers, they have been less well studied within HCT. Improvements in risk adjustment strategies in HCT would inform patient selection, patient counseling, and quality reporting. The objective of the current study was to determine whether pre‐HCT PROs, in particular physical health, predict survival among patients undergoing autologous or allogeneic transplantation.METHODSIn this secondary analysis, the authors studied pre‐HCT PROs that were reported by 336 allogeneic and 310 autologous HCT recipients enrolled in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study with broad representation of patients who underwent transplantation in the United States.RESULTSAmong allogeneic HCT recipients, the pre‐HCT Medical Outcomes Study Short Form‐36 Health Survey (SF‐36) physical component summary (PCS) scale independently predicted overall mortality (hazards ratio, 1.40 per 10‐point decrease;P<.001) and performed at least as well as currently used, non‐PRO risk indices. Survival probability estimates at 1 year for the first, second, third, and fourth quartiles of the baseline PCS were 50%, 65%, 75%, and 83%, respectively. Early post‐HCT decreases in PCS were associated with higher overall and treatment‐related mortality. When adjusted for patient variables included in the US Stem Cell Therapeutic Outcomes Database model for transplant center‐specific reporting, the SF‐36 PCS retained independent prognostic value.CONCLUSIONSPROs have the potential to improve prognostication in HCT. The authors recommend the routine collection of PROs before HCT, and consideration of the incorporation of PROs into risk adjustment for quality reporting.Cancer2016;122:91–98.©2015 American Cancer Society.
Progress in Synthesis of Highly Active and Stable Nickel‐Based Catalysts for Carbon Dioxide Reforming of Methane
Authors: Kawi Sibudjing , Kathiraser Yasotha , Ni Jun , Oemar Usman , Li Ziwei , Saw Eng Toon 
Published: October 2015

AbstractIn recent decades, rising anthropogenic greenhouse gas emissions (mainly CO2 and CH4) have increased alarm due to escalating effects of global warming. The dry carbon dioxide reforming of methane (DRM) reaction is a sustainable way to utilize these notorious greenhouse gases. This paper presents a review of recent progress in the development of nickel‐based catalysts for the DRM reaction. The enviable low cost and wide availability of nickel compared with noble metals is the main reason for persistent research efforts in optimizing the synthesis of nickel‐based catalysts. Important catalyst features for the rational design of a coke‐resistant nickel‐based nanocatalyst for the DRM reaction are also discussed. In addition, several innovative developments based on salient features for the stabilization of nickel nanocatalysts through various means (which include functionalization with precursors, synthesis by plasma treatment, stabilization/confinement on mesoporous/microporous/carbon supports, and the formation of metal oxides) are highlighted. The final part of this review covers major issues and proposed improvement strategies pertaining to the rational design of nickel‐based catalysts with high activity and stability for the DRM reaction.
Molecular Catalyst Immobilized Photocathodes for Water/Proton and Carbon Dioxide Reduction
Authors: Tian Haining 
Published: October 2015

AbstractAs one of the components in a tandem photoelectrochemical cell for solar‐fuel production, the photocathode carries out the reduction reaction to convert solar light and the corresponding substrate (e.g., proton and CO2) into target fuels. Immobilizing molecular catalysts onto the photocathode is a promising strategy to enhance the interfacial electron/hole‐transfer process and to improve the stability of the catalysts. Furthermore, the molecular catalysts are beneficial in improving the selectivity of the reduction reaction, particularly for CO2 reduction. On the photocathode, the binding mode of the catalysts and the arrangement between the photosensitizer and the catalyst also play crucial roles in the performance and stability of the final device. How to firmly and effectively immobilize the catalyst on the photoelectrode is now becoming a scientific question. Recent publications on molecular catalyst immobilized photocathodes are therefore surveyed.
Competitive SWIFT cluster templates enhance detection of aging changes
Authors: Rebhahn Jonathan A. , Roumanes David R. , Qi Yilin , Khan Atif , Thakar Juilee , Rosenberg Alex , Lee F. Eun‐Hyung , Quataert Sally A. , Sharma Gaurav , Mosmann Tim R. 
Published: October 2015

AbstractClustering‐based algorithms for automated analysis of flow cytometry datasets have achieved more efficient and objective analysis than manual processing. Clustering organizes flow cytometry data into subpopulations with substantially homogenous characteristics but does not directly address the important problem of identifying the salient differences in subpopulations between subjects and groups. Here, we address this problem by augmenting SWIFT—a mixture model based clustering algorithm reported previously. First, we show that SWIFT clustering using a “template” mixture model, in which all subpopulations are represented, identifies small differences in cell numbers per subpopulation between samples. Second, we demonstrate that resolution of inter‐sample differences is increased by “competition” wherein a joint model is formed by combining the mixture model templates obtained from different groups. In the joint model, clusters from individual groups compete for the assignment of cells, sharpening differences between samples, particularly differences representing subpopulation shifts that are masked under clustering with a single template model. The benefit of competition was demonstrated first with a semisynthetic dataset obtained by deliberately shifting a known subpopulation within an actual flow cytometry sample. Single templates correctly identified changes in the number of cells in the subpopulation, but only the competition method detected small changes in median fluorescence. In further validation studies, competition identified a larger number of significantly altered subpopulations between young and elderly subjects. This enrichment was specific, because competition between templates from consensus male and female samples did not improve the detection of age‐related differences. Several changes between the young and elderly identified by SWIFT template competition were consistent with known alterations in the elderly, and additional altered subpopulations were also identified. Alternative algorithms detected far fewer significantly altered clusters. Thus SWIFT template competition is a powerful approach to sharpen comparisons between selected groups in flow cytometry datasets. © 2015 The Authors. Published Wiley Periodicals Inc.
Detection of early stage changes associated with adipogenesis using Raman spectroscopy under aseptic conditions
Authors: Mitchell Adam , Ashton Lorna , Yang Xuebin B. , Goodacre Royston , Smith Alistair , Kirkham Jennifer 
Published: October 2015

AbstractThere is growing interest in the development of methods capable of non‐invasive characterization of stem cells prior to their use in cell‐based therapies. Raman spectroscopy has previously been used to detect biochemical changes commensurate with the osteogenic, cardiogenic, and neurogenic differentiation of stem cells. The aim of this study was to characterize the adipogenic differentiation of live adipose derived stem cells (ASCs) under aseptic conditions. ASCs were cultured in adipogenic or basal culture medium for 14 days in customized culture flasks containing quartz windows. Raman spectra were acquired every 3 days. Principal component analysis (PCA) was used to identify spectral changes in the cultures over time. Adipogenic differentiation was confirmed using quantitative reverse transcription polymerase chain reaction for the marker genes PPARγ and ADIPOQ and Oil red O staining performed. PCA demonstrated that lipid associated spectral features varied throughout ASC differentiation with the earliest detection of the lipid associated peak at 1,438 cm−1 after 3 days of induction. After 7 days of culture there were clear differences between the spectra acquired from ASCs in adipogenic or basal culture medium. No changes were observed in the spectra acquired from undifferentiated ASCs. Significant up‐regulation in the expression of both PPARγ and ADIPOQ genes (P < 0.001) was observed after 14 days of differentiation as was prominent Oil red O staining. However, the Raman sampling process resulted in weaker gene expression compared with ASCs that had not undergone Raman analysis. This study demonstrated that Raman spectroscopy can be used to detect biochemical changes associated with adipogenic differentiation in a non‐invasive and aseptic manner and that this can be achieved as early as three days into the differentiation process. © 2015 The Authors. Published by Wiley Periodicals, Inc. on behalf of the International Society for Advancement of Cytometry.
Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish
Authors: Montgomery Jacob E. , Wiggin Timothy D. , Rivera‐Perez Luis M. , Lillesaar Christina , Masino Mark A. 
Published: October 2015

ABSTRACTZebrafish intraspinal serotonergic neuron (ISN) morphology and distribution have been examined in detail at different ages; however, some aspects of the development of these cells remain unclear. Although antibodies to serotonin (5‐HT) have detected ISNs in the ventral spinal cord of embryos, larvae, and adults, the only tryptophan hydroxylase (tph) transcript that has been described in the spinal cord is tph1a. Paradoxically, spinal tph1a is only expressed transiently in embryos, which brings the source of 5‐HT in the ISNs of larvae and adults into question. Because the pet1 and tph2 promoters drive transgene expression in the spinal cord, we hypothesized that tph2 is expressed in spinal cords of zebrafish larvae. We confirmed this hypothesis through in situ hybridization. Next, we used 5‐HT antibody labeling and transgenic markers of tph2‐expressing neurons to identify a transient population of ISNs in embryos that was distinct from ISNs that appeared later in development. The existence of separate ISN populations may not have been recognized previously due to their shared location in the ventral spinal cord. Finally, we used transgenic markers and immunohistochemical labeling to identify the transient ISN population as GABAergic Kolmer‐Agduhr double‐prime (KA″) neurons. Altogether, this study revealed a novel developmental paradigm in which KA″ neurons are transiently serotonergic before the appearance of a stable population of tph2‐expressing ISNs. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 673–687, 2016
Synthesis of the Single‐Crystalline Form and First‐Principles Calculations of Photomagnetic Copper(II) Octacyanidomolybdate(IV)
Authors: Umeta Yoshikazu , Chorazy Szymon , Nakabayashi Koji , Ohkoshi Shin‐ichi 
Published: October 2015

AbstractA gel crystallization technique was successfully applied in the pioneering preparation of a single‐crystalline form of the three‐dimensional copper(II) octacyanidomolybdate(IV) network, which is a photomagnetic material. This assembly crystallizes with the formula {[CuII(H2O)]2[MoIV(CN)8]}·2H2O in the tetragonal crystal system and reveals a three‐dimensional cyanido‐bridged framework constructed of five‐coordinate square‐pyramidal [CuII(H2O)(NC)4]2– complexes and [MoIV(CN)8]4– ions of square‐antiprismatic geometry. First‐principles calculations by the GGA + U method indicate that the visible‐light absorption band, crucial for the observation of a photomagnetic effect, is interpreted in terms of MoIV to CuII charge transfer, which is enabled owing to the accompanying pz → spx transition of the nitrogen atoms of the bridging cyanido ligands. The optical transitions in the visible range are anisotropic, and the most efficient light absorption along the [111] direction corresponds to the alignment of the cyanide bridges.
Hydride Abstraction and Deprotonation – an Efficient Route to Low Coordinate Phosphorus and Arsenic Species
Authors: Taylor Laurence J. , Bühl Michael , Wawrzyniak Piotr , Chalmers Brian A. , Woollins J. Derek , Slawin Alexandra M. Z. , Fuller Amy L. , Kilian Petr 
Published: October 2015

AbstractTreatment of Acenap(PiPr2)(EH2) (Acenap = acenaphthene‐5,6‐diyl; 1a, E = As; 1b, E = P) with Ph3C·BF4 resulted in hydride abstraction to give [Acenap(PiPr2)(EH)][BF4] (2a, E = As; 2b, E = P). These represent the first structurally characterised phosphino/arsino‐phosphonium salts with secondary arsine/phosphine groups, as well as the first example of a Lewis base stabilised primary arsenium cation. Compounds 2a and 2b were deprotonated with NaH to afford low coordinate species Acenap(PiPr2)(E) (3a, E = As; 3b, E = P). This provides an alternative and practical synthetic pathway to the phosphanylidene‐σ4‐phosphorane 3b and provides mechanistic insight into the formation of arsanylidene‐σ4‐phosphorane 3a, indirectly supporting the hypothesis that the previously reported dehydrogenation of 1a occurs via an ionic mechanism.
Ferrocene‐Based N‐Heterocyclic Carbenes with Functionalised Benzyl Substituents
Authors: Thie Charlotte , Bruhn Clemens , Siemeling Ulrich 
Published: October 2015

AbstractWe describe herein N‐heterocyclic carbenes (NHCs) with a 1,1′‐ferrocenylene backbone that contain substituents at the nitrogen atoms relevant for applications in the area of metallopharmaceuticals, namely benzyl units functionalised with dimethylamino and methoxy groups at the para position. These carbenes are too unstable for isolation. They were generated from the corresponding formamidinium tetrafluoroborates by deprotonation and efficiently trapped in situ. Trapping with elemental selenium afforded the corresponding selenourea derivatives, the 77Se NMR chemical shifts of which are in accord with the comparatively high electrophilicity typical of expanded‐ring NHCs. Coordinative trapping with [{Rh(μ‐Cl)(cod)}2] (cod = cycloocta‐1,5‐diene) furnished air‐stable complexes of the type [RhCl(cod)(NHC)], the benzyl CH2 groups of which are engaged in pronounced anagostic C–H···Rh interactions, both in solution and in the solid state.
Surface Termination Effect of Boron‐Doped Diamond on the Electrochemical Oxidation of Adenosine Phosphate
Authors: Asai Kai , Ivandini Tribidasari A. , Falah Muhammad M. , Einaga Yasuaki 
Published: October 2015

AbstractElectrochemical oxidation of adenosine phosphates, including adenosine 5′‐monophosphate (AMP), adenosine 5′‐diphosphate (ADP), and adenosine 5′‐triphosphate (ATP), have been studied using boron‐doped diamond (BDD) electrodes. Cyclic voltammograms in phosphate buffer solution pH 7.4 showed a typical oxidation peak at the potential of around +1.3 V (vs. Ag/AgCl) attributable to the oxidation of adenine base moiety. This peak appears at both cathodically and anodically treated BDD. However, investigation at low pH showed, whereas the oxidation peak could be well observed for the oxidation of each AMP, ADP, and ATP at cathodically treated BDD, it was only found for the oxidation of AMP at anodically‐treted BDD electrodes. Linear calibration curve can be achieved in the concentration range of 20 to 200 μM with an average detection limit of 2 μM (S/N=3). Furthermore, cathodic treatment has demonstrated its ability to maintain the electrode surface from biofouling, resulting in the excellent stability of current responses.
Electrochemical Determination of Bisphenol A Using a Molecularly Imprinted Chitosan‐acetylene Black Composite Film Modified Glassy Carbon Electrode
Authors: Tan Yuanbin , Jin Jing , Zhang Shenghui , Shi Zhen , Wang Jinshou , Zhang Jingdong , Pu Wenhong , Yang Changzhu 
Published: October 2015

AbstractIn this study, a simple electrochemical sensor based on glassy carbon electrode (GCE) modified with molecularly imprinted chitosan film doping with acetylene black (AB) has been developed for the determination of bisphenol A (BPA). Several important parameters controlling the performance of the sensor are investigated and optimised. Two good linear relationships between the oxidation peak current and BPA concentration are obtained in the ranges from 0.005 to 0.20 μM and 0.50 to 10.00 μM with a detection limit of 2 nM (S/N=3). Meanwhile, the fabricated sensor shows good selectivity and high sensitivity. The construction of this sensor is relatively simple and provided a rapid and economical electrochemical method for the determination of BPA. The sensor is successfully employed to detect BPA in drinking water samples.
Regional volumes in brain stem and cerebellum are associated with postural impairments in young brain‐injured patients
Authors: Drijkoningen David , Leunissen Inge , Caeyenberghs Karen , Hoogkamer Wouter , Sunaert Stefan , Duysens Jacques , Swinnen Stephan P 
Published: October 2015

AbstractMany patients with traumatic brain injury (TBI) suffer from postural control impairments that can profoundly affect daily life. The cerebellum and brain stem are crucial for the neural control of posture and have been shown to be vulnerable to primary and secondary structural consequences of TBI. The aim of this study was to investigate whether morphometric differences in the brain stem and cerebellum can account for impairments in static and dynamic postural control in TBI. TBI patients (n = 18) and healthy controls (n = 30) completed three challenging postural control tasks on the EquiTest® system (Neurocom). Infratentorial grey matter (GM) and white matter (WM) volumes were analyzed with cerebellum‐optimized voxel‐based morphometry using the spatially unbiased infratentorial toolbox. Volume loss in TBI patients was revealed in global cerebellar GM, global infratentorial WM, middle cerebellar peduncles, pons and midbrain. In the TBI group and across both groups, lower postural control performance was associated with reduced GM volume in the vermal/paravermal regions of lobules I–IV, V and VI. Moreover, across all participants, worse postural control performance was associated with lower WM volume in the pons, medulla, midbrain, superior and middle cerebellar peduncles and cerebellum. This is the first study in TBI patients to demonstrate an association between postural impairments and reduced volume in specific infratentorial brain areas. Volumetric measures of the brain stem and cerebellum may be valuable prognostic markers of the chronic neural pathology, which complicates rehabilitation of postural control in TBI. Hum Brain Mapp 36:4897–4909, 2015. © 2015 Wiley Periodicals, Inc.
Abnormal functional integration of thalamic low frequency oscillation in the BOLD signal after acute heroin treatment
Authors: Denier Niklaus , Schmidt André , Gerber Hana , Vogel Marc , Huber Christian G. , Lang Undine E. , Riecher‐Rossler Anita , Wiesbeck Gerhard A. , Radue Ernst‐Wilhelm , Walter Marc , Borgwardt Stefan 
Published: October 2015

AbstractHeroin addiction is a severe relapsing brain disorder associated with impaired cognitive control, including deficits in attention allocation. The thalamus has a high density of opiate receptors and is critically involved in orchestrating cortical activity during cognitive control. However, there have been no studies on how acute heroin treatment modulates thalamic activity. In a cross‐over, double‐blind, vehicle‐controlled study, 29 heroin‐maintained outpatients were studied after heroin and placebo administration, while 20 healthy controls were included for the placebo condition only. Resting‐state functional magnetic resonance imaging was used to analyze functional integration of the thalamus by three different resting state analysis techniques. Thalamocortical functional connectivity (FC) was analyzed by seed‐based correlation, while intrinsic thalamic oscillation was assessed by analysis of regional homogeneity (ReHo) and the fractional amplitude of low frequency fluctuations (fALFF). Relative to the placebo treatment and healthy controls, acute heroin administration reduced thalamocortical FC to cortical regions, including the frontal cortex, while the reductions in FC to the mediofrontal cortex, orbitofrontal cortex, and frontal pole were positively correlated with the plasma level of morphine, the main psychoactive metabolite of heroin. Furthermore, heroin treatment was associated with increased thalamic ReHo and fALFF values, whereas fALFF following heroin exposure correlated negatively with scores of attentional control. The heroin‐associated increase in fALFF was mainly dominated by slow‐4 (0.027–0.073 Hz) oscillations. Our findings show that there are acute effects of heroin within the thalamocortical system and may shed new light on the role of the thalamus in cognitive control in heroin addiction. Future research is needed to determine the underlying physiological mechanisms and their role in heroin addiction. Hum Brain Mapp 36:5287–5300, 2015. © 2015 Wiley Periodicals, Inc.