bluuebunny/crossref_metadata_2025_split huggingface dataset:
iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review
Authors: Ali Eltahir Abdelrazig Mohamed , Smaida Rana , Meyer Morgane , Ou Wenxin , Li Zongjin , Han Zhongchao , Benkirane-Jessel Nadia , Gottenberg Jacques Eric , Hua Guoqiang 
Published: June 2024

AbstractCartilage, an important connective tissue, provides structural support to other body tissues, and serves as a cushion against impacts throughout the body. Found at the end of the bones, cartilage decreases friction and averts bone-on-bone contact during joint movement. Therefore, defects of cartilage can result from natural wear and tear, or from traumatic events, such as injuries or sudden changes in direction during sports activities. Overtime, these cartilage defects which do not always produce immediate symptoms, could lead to severe clinical pathologies. The emergence of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine, providing a promising platform for generating various cell types for therapeutic applications. Thus, chondrocytes differentiated from iPSCs become a promising avenue for non-invasive clinical interventions for cartilage injuries and diseases. In this review, we aim to highlight the current strategies used for in vitro chondrogenic differentiation of iPSCs and to explore their multifaceted applications in disease modeling, drug screening, and personalized regenerative medicine. Achieving abundant functional iPSC-derived chondrocytes requires optimization of culture conditions, incorporating specific growth factors, and precise temporal control. Continual improvements in differentiation methods and integration of emerging genome editing, organoids, and 3D bioprinting technologies will enhance the translational applications of iPSC-derived chondrocytes. Finally, to unlock the benefits for patients suffering from cartilage diseases through iPSCs-derived technologies in chondrogenesis, automatic cell therapy manufacturing systems will not only reduce human intervention and ensure sterile processes within isolator-like platforms to minimize contamination risks, but also provide customized production processes with enhanced scalability and efficiency.
Graphical abstract
Adaptive scheduling-based fine-grained greybox fuzzing for cloud-native applications
Authors: Yang Jiageng , Liu Chuanyi , Fang Binxing 
Published: June 2024

AbstractCoverage-guided fuzzing is one of the most popular approaches to detect bugs in programs. Existing work has shown that coverage metrics are a crucial factor in guiding fuzzing exploration of targets. A fine-grained coverage metric can help fuzzing to detect more bugs and trigger more execution states. Cloud-native applications that written by Golang play an important role in the modern computing paradigm. However, existing fuzzers for Golang still employ coarse-grained block coverage metrics, and there is no fuzzer specifically for cloud-native applications, which hinders the bug detection in cloud-native applications. Using fine-grained coverage metrics introduces more seeds and even leads to seed explosion, especially in large targets such as cloud-native applications. Therefore, we employ an accurate edge coverage metric in fuzzer for Golang, which achieves finer test granularity and more accurate coverage information than block coverage metrics. To mitigate the seed explosion problem caused by fine-grained coverage metrics and large target sizes, we propose smart seed selection and adaptive task scheduling algorithms based on a variant of the classical adversarial multi-armed bandit (AMAB) algorithm. Extensive evaluation of our prototype on 16 targets in real-world cloud-native infrastructures shows that our approach detects 233% more bugs than go-fuzz, achieving an average coverage improvement of 100.7%. Our approach effectively mitigates seed explosion by reducing the number of seeds generated by 41% and introduces only 14% performance overhead.
Repercussions of the COVID-19 pandemic on the HIV care continuum and related factors in economically disadvantaged nations: an integrated analysis using mixed-methods systematic review
Authors: Ojukwu Emmanuela , Pashaei Ava , Maia Juliana Cunha , Omobhude Oserekpamen Favour , Tawfik Abdulaziz , Nguyen Yvonne 
Published: June 2024

AbstractBackgroundThe COVID-19 pandemic affected the self-management and care of people living with HIV, requiring adaptations in the way health services are provided. However, it is unclear how these changes impacted HIV care in low-income countries.MethodsA systematic review including the current evidence related to changes in HIV care continuum during COVID-19 was conducted through a systematic search in the online databases including CINAHL, OVID-Medline, CAB Direct, and OVID-Embase. A two-step screening process was carried out to include eligible papers and reports according to inclusion criteria.ResultsFrom the searches we identified 21 total studies published between 2021 and 2024, the studies revealed mostly negative impacts on all stages of the HIV care continuum in low-income countries. There were impacts related to the blocking measures due to COVID-19, fear of contracting the disease, difficulties in providing resources such as income, food and transports, reductions in the provision of care from prevention to viral suppression.ConclusionOverall, researchers identified several negative impacts of COVID-19 restrictions on HIV care continuum during pandemic; however, some observations indicated indirect positive impacts on some aspects of HIV care. Decline in HIV care practices during pandemic compared to before pandemic were observed including using preventative methods, counseling and testing, receiving HIV healthcare services, HIV medical appointments, antiretroviral adherence, engagement with treatment, and poor viral suppression. However, in some evidence improvement in ART adherence and PrEP use were observed.
Using proximity loggers in studies of sheep behavior: an estimation of the daily frequency of water consumption
Authors: Abecia José A. , Erden Pelin , Canto Francisco 
Published: June 2024

Abstract
Background
Proximity loggers are a biotelemetry technology used to quantify animal–animal interactions non-invasively. They are small devices can be affixed to a target animal and detects and records if another device is within a certain distance, which can provide unprecedented insights into individual behavior and interactions with other animals or other aspects of the environment. Proximity loggers also can record the duration and distance between the two or more individuals detected, and have been used to study a diverse array of interactions. Studying drinking behavior in sheep is important for several critical reasons, such as improving animal welfare, enhancing productivity, managing resources efficiently, and ensuring sustainable agricultural practices. The objective of this study was to test the capacity for Bluetooth Low Energy proximity loggers to quantify drinking habits in sheep (n = 7 adult females). At all times, they had access to water from two drinking troughs. Animals wore neck collars that contained a mobile logger, and two stationary loggers were placed under the drinking troughs. To store the records downloaded from the stationary loggers, a gateway was placed close to the troughs. The mobile loggers were programmed as beacons to transmit their ID to the stationary loggers, which were programmed as receivers to scan the proximity of the mobile loggers, record the time, the IDs of the mobile loggers, and the received signal strength of the contact with the mobile loggers.

Results
Ewes visited the drinking troughs 2.4 ± 0.5 times per day (rank 1.4–2.9), most frequently (42%) between 0800 and 1000 h, and 84% occurred in the daytime. Mean length of each water intake was 1.72 ± 0.30 min. The cosinor analysis of the distribution of drinking events revealed a significant (P < 0.0001) 24-h circadian rhythm in drinking events, and the acrophase (time of the highest proportion of events) occurred at 1054 h.

Conclusions
Considering that studying water intake in sheep is crucial for optimizing their health, welfare, and management, the proximity loggers were demonstrated to be appropriate for documenting the drinking habits of sheep, and probably, would be suitable for studies of other behaviors that involve approaching other animals or objects.
Extending the theory of planned behavior model to explain people’s behavioral intentions to follow China’s AI generated content law
Authors: Li Jie-Chun , Lin Yi , Yang Yi-Chun 
Published: June 2024

AbstractAI Generated Content Law was extensively promoted in 2023; hence, it is crucial to uncover factors influencing people’s behavioral intentions to comply with the AI Generated Content Law. This study extends the theory of planned behavior to explore the factors influencing people to follow AI Generated Content Law in China. In addition to the factors in TPB model, such as one’s attitudinal factors, normative factors, and perceived behavioral control, we add another factor-moral obligation to extend the theory of planned behavior model. We used convenient sampling and there were 712 effective samples. Using the statistical software Amos17.0, the result shows that attitude, subjective norms, perceived behavioral control and moral obligation all have positive effects on intentions to follow AI Generated Content Law.
Can watching the World Cup make you mentally healthier? Positive associations between involvement in physical activities and flourishing were mediated by psychological need satisfaction
Authors: Zhou Hui , Hui Bryant Pui Hung , Yang Hong Mian , Wu Anise M. S. 
Published: June 2024

Abstract
Background
The current understanding of the relationship between physical activity involvement and flourishing, as well as the underlying psychological mechanisms, remains limited. Building upon the basic psychological need theory, this study investigates whether and how engaging in physical activities, either as a spectator (e.g., in sports events such as the World Cup) or a participant, explains individual differences in flourishing.

Methods
A total of 1201 Hong Kong-based Chinese adults (Mage = 42.90, SD = 11.40; 54% female) completed an anonymous online survey from the quarter-final to final stages of the 2022 FIFA World Cup in December 2022.

Results
Findings showed that spectator (World Cup) involvement and participant involvement were positively correlated. Moreover, both types of involvements were correlated with flourishing. In addition to the hypothesized positive association with relatedness satisfaction, spectator (World Cup) involvement was also demonstrated significant associations with autonomy and competence satisfaction. Path analysis indicated that associations between physical activities and flourishing were partially mediated by the satisfaction of all three basic psychological needs.

Conclusions
This study is the first to apply the basic psychological need theory in the context of physical activity and supports its relevance in understanding individual differences in flourishing. Different stakeholders are encouraged to recognize the benefits of both spectator and participant involvements in physical activities, which may help them develop supportive strategies (e.g., physical activities with parents, sports events for spectators and participants, and funding for media/communities) in mental health promotion.
Optimization-based convolutional neural model for the classification of white blood cells
Authors: Devi Tulasi Gayatri , Patil Nagamma 
Published: June 2024

AbstractWhite blood cells (WBCs) are one of the most significant parts of the human immune system, and they play a crucial role in diagnosing the characteristics of pathologists and blood-related diseases. The characteristics of WBCs are well-defined based on the morphological behavior of their nuclei, and the number and types of WBCs can often determine the presence of diseases or illnesses. Generally, there are different types of WBCs, and the accurate classification of WBCs helps in proper diagnosis and treatment. Although various classification models were developed in the past, they face issues like less classification accuracy, high error rate, and large execution. Hence, a novel classification strategy named the African Buffalo-based Convolutional Neural Model (ABCNM) is proposed to classify the types of WBCs accurately. The proposed strategy commences with collecting WBC sample databases, which are preprocessed and trained into the system for classification. The preprocessing phase removes the noises and training flaws, which helps improve the dataset's quality and consistency. Further, feature extraction is performed to segment the WBCs, and African Buffalo fitness is updated in the classification layer for the correct classification of WBCs. The proposed framework is modeled in Python, and the experimental analysis depicts that it achieved 99.12% accuracy, 98.16% precision, 99% sensitivity, 99.04% specificity, and 99.02% f-measure. Furthermore, a comparative assessment with the existing techniques validated that the proposed strategy obtained better performances than the conventional models.
The simulation of the Indo-Pacific warm pool SST warming trend in CMIP5 and CMIP6
Authors: Bai Wenrong , Liu Hailong , Lin Pengfei , Shen Hongyan 
Published: June 2024

AbstractThis paper evaluates Indo-Pacific warm pool (IPWP) sea surface temperature (SST) warming biases of Coupled Model Intercomparison Project Phase 5 (CMIP5) and CMIP6. The IPWP warming trend in the CMIP5 multi-model ensemble (MME) is closer to observation than in CMIP6 MME, but the IPWP expanding trend is the opposite. There is no qualitative improvement in the simulation of IPWP warming from CMIP5 to CMIP6. In addition, four metrics were used to investigate the performance of Indo-Pacific region warming trends in all models. CMIP6 models perform better than CMIP5 with smaller root mean square error and bias in MME and higher skill scores in MME and top models, which is tightly linked to their better performance in simulating associated physical processes in CMIP6 models. IPWP warming biases are mainly attributed to the combined effects of positive atmospheric process biases and negative ocean dynamics term biases. The positive atmospheric process biases are primarily related to the shortwave radiation and latent heat flux from atmospheric forcing, the latter of which can be attributed to the biases in surface wind fields. Compared with CMIP5 models, the IPWP warming simulated by CMIP6 models is weaker, related to the less robust atmospheric processes and the shallower thermocline anomalies simulated by CMIP6.
Dietary salt intake and kidney function in rural Senegalese populations: a cross-sectional study
Authors: Modou Ndongo , Motoula Latou Lot Nehemie , Maimouna Toure , Dia Amadou Diop , Seck Sidy Mohamed 
Published: June 2024

Abstract
Introduction
High salt intake is a major risk factor for hypertension and its complications such as chronic kidney disease (CKD) and cardiovascular diseases. The present study aimed to determine level of sodium consumption and its relation with kidney function in the rural populations of Ferlo (centre of Senegal).

Subjects and methods
We performed a cross-sectional study including 400 volunteers aged > 18 years. Clinical, biological and dietary data were collected during household visits. Daily sodium intake was measured in the 24 h-urine outpout and CKD was defined as eGFR < 60 ml/min. Linear regression analysis was used to assess association between sodium intake and covariates.

Results
Mean age was 46.42 ± 15.60 and sex-ratio was 1.05. Prevalence of hypertension, CKD and overweight were 21.5, 11.7 and 20.5%, respectively. The median daily salt intake was 11.7 g with interquartile range of 14.8 g. Only 11.25% of participants consumed less than 5 g/day. After multivariate analysis, high salt intake was associated with age > 60 years, overweight and CKD. However, gender and hypertension were not significantly associated with salt intake. Industrial broths (91.5%) and bread (85%) represented the main sources of dietary salt.

Conclusion
This study revealed high levels of daily salt intake contrasting with low potassium intakes in the majority of participants. Participants with CKD, overweight and age > 60 years presented higher salt consumption. Stategies to reduce salt consumption are urgently needed to reduce burden of CKD in rural Senegalese populations.
Use of concept mapping to inform a participatory engagement approach for implementation of evidence-based HPV vaccination strategies in safety-net clinics
Authors: Tsui Jennifer , Shin Michelle , Sloan Kylie , Mackie Thomas I. , Garcia Samantha , Fehrenbacher Anne E. , Crabtree Benjamin F. , Palinkas Lawrence A. 
Published: June 2024

Abstract
Background
Multiple evidence-based strategies (EBS) for promoting HPV vaccination exist. However, adolescent HPV vaccination rates remain below target levels in communities at high risk for HPV-associated cancers and served by safety-net clinics. Participatory engaged approaches are needed to leverage the expertise of community and clinical partners in selecting EBS relevant to their local context. We engaged concept mapping as a method to inform the adoption and adaptation of EBS that seeks to empower implementation partners to prioritize, select, and ultimately implement context-relevant EBS for HPV vaccination.

Methods
Using 38 EBS statements generated from qualitative interviews and national HPV vaccine advocacy sources, we conducted a modified concept mapping activity with partners internal to safety-net clinics and external community members in two study sites of a larger implementation study (Greater Los Angeles and New Jersey), to sort EBS into clusters and rate each EBS by importance and feasibility for increasing HPV vaccination within safety-net clinics. Concept mapping findings (EBS statement ratings, ladder graphs and go-zones) were shared with leaders from a large federally qualified health center (FQHC) system (focusing on three clinic sites), to select and implement EBS over 12 months.

Results
Concept mapping participants (n=23) sorted and rated statements, resulting in an eight-cluster solution: 1) Community education and outreach; 2) Advocacy and policy; 3) Data access/quality improvement monitoring; 4) Provider tracking/audit and feedback; 5) Provider recommendation/communication; 6) Expanding vaccine access; 7) Reducing missed opportunities; and 8) Nurse/staff workflow and training. The FQHC partner then selected to intervene on eight of 17 EBS statements in the “go-zone” for action, with three from “reducing missed opportunities,” two from “nurse/staff workflow and training,” and one each from “provider tracking/audit and feedback,” “provider recommendation/communication,” and “expanding vaccine access,” which the research team addressed through the implementation of three multi-level intervention strategies (e.g., physician communication training, staff training and workflow assessment, audit and feedback of clinic processes).

Conclusions
Concept mapping provided a powerful participatory approach to identify multilevel EBS for HPV vaccination relevant to the local safety-net clinic context, particularly when several strategies exist, and prioritization is necessary. This study demonstrates how a clinic system benefited directly from the ratings and prioritization of EBS by multilevel clinic and community partners within the broader safety-net clinic context to identify and adapt prioritized solutions needed to advance HPV vaccine equity.
Efficacy of imetelstat on red blood cell (RBC)-transfusion independence (TI) in the absence of platelet transfusions or myeloid growth factors in IMerge.
Authors: Zeidan Amer Methqal , Santini Valeria , Platzbecker Uwe , Sekeres Mikkael A. , Savona Michael R. , Fenaux Pierre , Madanat Yazan , Raza Azra , Xia Qi , Sun Libo , Riggs Jennifer , Shah Sheetal , Navada Shyamala Chendeal , Berry Tymara , Komrokji Rami S. 
Published: June 2024

6566 Background: In the IMerge trial (NCT02598661) of RBC transfusion-dependent (TD) patients (pts) with lower-risk myelodysplastic syndromes (LR-MDS) relapsed/refractory to or ineligible for erythropoiesis stimulating agents, imetelstat showed significant efficacy vs placebo (PBO) for 8-wk, 24-wk, and 1-y TI endpoints, with neutropenia and thrombocytopenia as the most common adverse events (Platzbecker. Lancet 2024). Supportive care was given to all pts as needed, per investigator discretion. Here we report RBC-TI rates in the absence of platelet transfusions or myeloid growth factor use. Separately, RBC-TI with mean central hemoglobin (Hb) rise of ≥1.5 g/d was assessed in all pts. Methods: Pts were randomized 2:1 to receive imetelstat (n=118) 7.5 mg/kg or PBO (n=60) Q4W IV until disease progression. Primary endpoint was 8-wk RBC-TI; 24-wk RBC-TI was a key secondary endpoint. Primary analysis cutoff was Oct 2022, with Oct 2023 cutoff for 1-y RBC-TI analyses. Results: Overall, 21/118 (18%) pts in the imetelstat group and 1/60 (2%) pts in the PBO group needed platelet transfusions; 41/118 (35%) and 2/60 (3%) pts received myeloid growth factors, respectively. Significantly higher percentages of pts achieved 8-wk, 24-wk, and 1-y RBC-TI with imetelstat vs PBO in the absence of either platelet transfusions or growth factor support (Table). In a separate analysis, 8-wk, 24-wk, and 1-y RBC-TI and concurrent Hb rise of ≥1.5 g/dL with imetelstat vs PBO occurred in 28% vs 2%, 23% vs 0%, and 17% vs 0% of pts, respectively (Table). Among responders, imetelstat increased median central Hb levels compared with PBO: 3.6 g/dL vs 0.8 g/dL for 8-wk, 4.2 g/dL vs 1.1 g/dL for 24-wk, and 5.2 g/dL vs 1.7 g/dL for 1-y RBC-TI. Conclusions: Results from this subanalysis confirm that pts who achieve RBC-TI with imetelstat do so without developing severe neutropenia and thrombocytopenia (functionally defined as needing myeloid growth factors or platelet transfusions, respectively), therefore not negating the clinical benefit of the drug. Imetelstat also led to significant rise in Hb levels in RBC-TI responders, particularly long-term responders. These data further support the efficacy of imetelstat in TD pts with LR-MDS. Clinical trial information: NCT02598661 . [Table: see text]