bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assess perimenopausal symptoms among women
Authors: Soumya. A , Nageswaran Karpagavalli , Purohit Nisha 
Published: June 2024

Change is inevitable in human life; it brings benefits, challenges and rebeginning. In women's lives, Perimenopause is the transitional time around menopause, and it is a regular transient change with challenges, like physiological, psychological and other changes. The women aware of these changes will help to cope with them in a better way and reduce their anxiety and stress. In this view, researchers felt a need to assess perimenopausal symptoms among women and associate the findings with baseline data.The data was collected using the quantitative research approach, the non-experimental exploratory, descriptive survey method. Two hundred samples met the sampling criteria from selected areas by the non-probability convenience sampling method.The significant findings of this study reveal that 58.5% of the sample had moderate perimenopausal with different somatic, psychological and uro-genetic symptoms. All variables are statistically significant in association with baseline data as the P value is less than 0.05.
Quality of life of elderly in old age home and in the community
Authors: Singh Rajendra , Singh Pranesh , Singh Reena , Singh Hutesh 
Published: June 2024

: Old age is a period of transition when one has to deal not only with the physical wellbeing, but also with the challenges of mental, social and economic wellbeing. The elderly essentially require understanding, compassionate care, unconditional love and support with human touch. Family is the basic unit of the society and our elderly are its roots, they need tender care, respect and regards.To find out the difference in old person’s quality of life, living in a old age home & in the community.This was an observational studyconducted at Government run old age home, Araji bag, Azamgarh and at the OPD of Government SDJH Medical College & Hospital, Chandeswar, Azamgarh, Uttar Pradesh. For assesment OPQoL (WHO) questioner was used.This study shows that mean of OPQoL in group 1 (at community/at Home) was 60.20±6.94 and Mean of OPQoL in group 2 (At Old age Home) was 53.83±8.24. Paired T-test also shows that senior citizens living with family members were happier than senior citizens living at old age home.This study suggests that senior citizens living with family members were happier than senior citizens living at old age home.
Penetapan Pencatatan Perkawinan Beda Agama Pasca Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023 Tinjauan Yuridis Terhadap Putusan Pengadilan Negeri Jakarta Utara (Nomor: 423/Pdt.P/2023/Pn.Jkt.Utr)
Authors: Harahap Sarah Azzura , Prihatinah Tri Lisiani , Faradz Haedah 
Published: June 2024

Pencatatan perkawinan beda agama dilaksanakan melalui penetapan pengadilan. Tujuan dalam penelitian ini adalah untuk mengetahui dasar pertimbangan hukum hakim pengadilan negeri Jakarta Utara Nomor: 423/Pdt.P/2023/Pn.Jkt.Utr dalam mengabulkan permohonan pencatatan perkawinan beda agama dan mengetahui akibat hukum dikeluarkannya Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023. Penelitian ini menggunakan metode pendekatan yuridis normatif dengan spesifikasi penelitian preskriptif. Sumber data yang digunakan adalah data sekunder. Metode pengumpulan data dilakukan dengan studi kepustakaan. Berdasarkan penelitian diperoleh hasil bahwa hakim dalam memutus perkara Nomor: 423/Pdt.P/2023/Pn.Jkt.Utr. mempertimbangkan ketentuan Pasal 35 Huruf a Undang – Undang Nomor 23 Tahun 2006 tentang Administrasi Kependudukan, Pasal 50 ayat (3) Peraturan Menteri Dalam Negeri Republik Indonesia Nomor 108 Tahun 2019 tentang Peraturan Pelaksanaan Peraturan Presiden Nomor 96 Tahun 2018 Tentang Persyaratan dan Tata Cara Pendaftaran Penduduk dan Pencatatan Sipil, serta fakta bahwa Para Pemohon menikah secara Katholik. Putusan tersebut bertentangan dengan Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023 tentang Petunjuk Bagi Hakim Dalam Mengadili Perkara Permohonan Pencatatan Perkawinan Antar-Umat yang Berbeda Agama dan Kepercayaan dan Pasal 2 Ayat (1) jo Pasal 8 Huruf f Undang- Undang Nomor 1 Tahun 1974 tentang Perkawinan. Sehingga, hakim seharusnya dapat menambahkan kedua peraturan tersebut sebagai dasar pertimbangannya. Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023 melahirkan akibat hukum perkawinan beda agama tidak dapat dicatatkan secara administratif kependudukan dan menutup celah hukum bagi perkawinan beda agama untuk mendapatkan pengakuan melalui penetapan pengadilan.
Pengaruh Struktur Kepemilikan Terhadap Penghindaran Pajak dengan CSR sebagai Variabel Mediasi
Authors: Ramadhani Intan , Az'mi Yanis Ulul 
Published: June 2024

Tax avoidance is a legal method for minimizing company taxes by exploiting loopholes in the tax system. Ownership structure plays an important role in a company's tax avoidance decisions, because the level of ownership can give rise to differences in attitudes in a company's decision-making, including decisions regarding tax avoidance activities. This research aims to analyze the mediating effect of corporate social responsibility ownership structure on tax avoidance. This research sample includes manufacturing companies listed on the Indonesia Stock Exchange. The sampling technique used in this research was purposive sampling, so the sample used amounted to 249 data. Path analysis is used as an analysis method. This research shows that ownership structure encourages corporate social responsibility practices in companies. The research results show that corporate social responsibility can mediate the influence of ownership structure on tax avoidance. The research provides main implications regarding the important role of social responsibility for companies to minimize the potential for tax avoidance.
Implementation of Imam Al-Ghazali's Perspective Character Values in Nahwu Learning at UMALA
Authors: Amalia Dian Risky , Huda Miftahul , Sugirma Sugirma , Hidayat Ahmad Fadhel Syakir , Sulaikho Siti 
Published: June 2024

تم العثور على العديد من مرتكبي الاحتيال في الأكاديميين وهم محور المشاكل التي يتعرض لها الإهتمام إلى كفاءة المعلمين في عملية التعلم الخاصة بهم. يزيد من التدقيق العام في كفاءة المعلمين الذين يفتقرون إلى غرس قيم الشخصية في تعلمهم. إن تطبيق قيم الشخصية في تعلم اللغة على أساس الإمام الغزالي هو هدف صالح في هذه الدراسة، وتحديداً في الموازنة بين المعرفة و "الأعمال". منهج البحث وصفي ويستخدم منهجًا كميًا ، وهو مقياس ليكرت مع أسلوب أخذ العينات غير الاحتمالية ، أي أخذ العينات الكلية من طلاب الفصل الثالث المتخصصين في تعليم اللغة العربية. نتج عن هذا البحث تصور الشخصيات الأربع الرئيسية على أساس الإمام الغزالي ، وهي الحكمة والشجاعة والسماحة والعدل التي يمكن تنفيذها في تعلم النحوى. أظهرت النتائج أن 96٪ موافقون بشدة ومتفقون ومعتدلون ، و 4٪ غير موافقين ، بحيث لم يحصلوا فقط على نظرية قواعد النحوية ولكن أيضًا على قيم الشخصية التي يمكن أن يطبقوها معًا. بناء على التوازن بين العلم العمل التي لها أثرها على البعد الاجتماعي، وهي مفتاح الحصول على السعادة في الدنيا والآخرة.
الكلمات المفتاحية: التنفيذ ، القيم الشخصية ، الإمام الغزالي ، النحو.
Effectiveness of Memorizing The Qur’an on Arabic Vocabulary Mastery Among Students at Ar-Rahmah Boarding School for Tahfīdz Qur’an Balikpapan
Authors: Hidayat Tatang , Sagala Sadiyah Ratnasari , Istianah Istianah , Khatimah Husnul , Qosim Muhammad Nanang , Balah Abdel Rahman Elsayed Elsayed Abdel Ghaffar 
Published: June 2024

This research aims to find out the influence of the ability to memorize the Qur'an on the Arabic vocabulary mastery among students of the boarding school for tahfīdz Qur’an Balikpapan, and follows the analytical descriptive approach to this goal. The methods used by the researcher to collect data are testing, observation and documentation. It is quantitative research with the design of causal association research with a sample of 31 students from the second stage in the preservation of the Qur'an. For data analysis, the researcher used regression equation, selection factors and importance testing. The results of this research show that there is a significant impact of the preservation of the Qur'an with the mastery of Arabic vocabulary. By calculating the importance test analysis that indicates that tvalue (7,482) is greater than ttable (2,045), H0 was rejected and H1 was accepted, which means that there is a significant influence between the ability to memorize the Qur’an to the Arabic vocabulary mastery. The percentage of the influence of Qur'anic memorization ability on the ruling of Arabic vocabulary is 65.9%, and 34.1% by other factors.
Keywords: Memorization, Al-Qur'an, Mastery, Arabic Vocabulary, Boarding School for Tahfīdz Qur’an
Feasibility and effectiveness of real time digital postoperative follow-up following bariatric surgery
Authors: Farinella Eleonora , Papakonstantinou Dimitrios , Koliakos Nikolaos , Maréchal Marie-Thérèse ,   Mathilde Poras1, Pau Luca , Requière Arnaud , Plumacker Alain , Briganti Giovanni 
Published: June 2024

Abstract

Introduction: With the global prevalence of obesity steadily increasing, bariatric surgery has gained significance in managing this health challenge. Fast-track healthcare pathways have shown promise in improving outcomes and patient satisfaction for bariatric surgery. In this study, we aimed to evaluate the safety and effectiveness of real-time digital postoperative follow-up using a smartphone application.Materials and methods Consecutive patients undergoing bariatric surgery at CHU Saint-Pierre university hospital between September 2022 and October 2023 were prospectively enrolled. Patients were instructed to download and install the application on their smartphones, which prompted them with predetermined daily questions. Depending on their responses, alerts could be generated for review by medical staff A three-tiered alert system (orange, red, red+) was implemented to signify increasing significance.Results During the study period, a total of 1119 alerts were recorded from 104 patients, with 39.3% occurring within the first seven postoperative days. Patient alert profiles were significantly associated with postoperative outcomes, with worsening outcomes observed from basic orange alerts to red + alerts. Patients with red + alerts had nearly a threefold increase in postoperative morbidity rates, emergency department visits, and readmissions. No significant differences in weight loss outcomes were observed. Patient response adherence was 67.5%, while the overall satisfaction with the use of the application was 94%.Conclusion Remote follow-up via a mobile application holds promise for enhancing the management of bariatric surgery patients, complementing traditional practices. The implementation of a three-tiered alert system may help identify patients at risk of serious complications, potentially reducing unnecessary emergency department and hospital resource utilization.
Fracture Toughness of Ovine TMJ Disc: Effects of Crack Length and Orientation
Authors: Salehipour saeed , Hashemi Ata 
Published: June 2024

Abstract

The human mandible experiences mechanical stress from several directions as a result of activities such as speaking, chewing, and other everyday actions. The TMJ disc facilitates mandibular motion and absorbs all of the stresses associated with daily activities. Thus, the TMJ disc is likely to be susceptible to rupture. Hence, it is crucial to investigate its susceptibility to failure and rupture. The aim of this study was to determine the impact of fracture orientation, sample thickness, and crack-to-width ratio on the amount of energy needed to cause the growth of flaws on the disc. Fracture toughness was investigated by conducting cyclic tensile testing on 40 ovine TMJ discs in two different notch orientations: anteroposterior and mediolateral. The J-integral was chosen as a measure of the critical fracture energy of the TMJ disc. The Shapiro-Wilk test showed that fracture toughness data did not follow a normal distribution (P-value < 0.05). Due to unequal variances, the Kruskal-Wallis test was used to examine the data. The study revealed that the fracture toughness in the anteroposterior direction was much higher than that of the mediolateral, indicating a superior ability to resist tearing and fracture in the anteroposterior direction. Furthermore, the study's findings revealed that both the direction of the crack and its initial crack-to-width ratio influenced the TMJ disc's fracture toughness. The study also evaluated TMJ disc failure patterns to better understand its pathophysiology. The results showed that the crack growth profile in two orientations has a completely different structure. The 2D finite element analysis results also indicated a significant relationship between the fracture toughness and the percentage of cracks, demonstrating that increasing the crack-to-width ratio leads to a rise in fracture toughness. These findings help understand TMJ injuries to the disk and develop better treatments.
Prevalence and predictors of condom use among people who inject drugs in Georgia
Authors: Kajaia Maia , Butsashvili Maia , DeHovitz Jack A. , Kamkamidze George , Gulbiani Lasha , Abzianidze Tinatin , DjibutiMD Mamuka 
Published: June 2024

Abstract

Background
People who inject drugs (PWID) are more likely to engage in risky sexual behavior placing them at high risk of acquiring HIV and other STIs. This study aims to assess the prevalence and predictors of inconsistent condom use with casual and/or paid sexual partners among PWID in Georgia.
Methods
Integrated Bio-Behavioral Surveillance Survey was conducted among PWID in seven major cities of Georgia. Study design was cross-sectional with respondent-driven sampling (RDS) methodology. Data collection was carried out through individual face-to-face interviews. In this paper we analysed subsample of 619 PWID who reported having casual and/or paid sexual partners during last 12 months and described prevalence and predictors of consistent condom use.
Results
Consistent condom use during casual and/or paid sex in past 12 months was reported by 49.4% of respondents. The likelihood of consistent use with casual and/or paid sexual partners was statistically significantly associated with residence, family income, drug use frequency, drug dependance and HIV risk self-perceptions. In multivariate analysis independent predictors of always using condom at casual/paid sex during the last 12 months were place of residence (aOR = 6.4; 95% CI: 3.2–12.7), family income (aOR = 2.1; 95% CI:1.3–3.5) and drug use frequency (aOR = 0.6; 95% CI: 0.4–0.9).
Conclusion
The study revealed low prevalence of consistent condom use with casual and/or paid sexual partners among PWID in Georgia. Integration of safe sex educational interventions in harm reduction services will improve the rates of condom use among PWID and should focus PWID with lower socio-economic status and residing outside capital city.
Puerariae Flos promotes apoptosis through the ESR1-ERK1/2 signaling pathway to intervene in alcoholic hepatocellular carcinoma
Authors: Li Jun , An Mingyu , Cheng Guo , Luo DiDong , Zhang Nannan 
Published: June 2024

Abstract

Ethnopharmacological relevance: Increasing evidence indicates that conventional traditional Chinese medicine (TCM) plays a cardinal role in oncological remedies. Initially, our research group focused on research related to the sobering-up and liver-protecting effects of Gehua jiecheng fang, and found that these plants also have anticancer properties. Among these pathogens, Puerariae Flos (PF) is the main component of the fungus, and there is also literature supporting the use of PF for HCC care.
Aim of the study: PF is utilized to treat tumors in China. However, its effect on and mechanism involved in alcohol-associated hepatocellular carcinoma (alcohol-related HCC) remain elusive. This investigation aimed to address this knowledge gap through experiments and bioinformatics.
Materials and methods: Limid chromatography-tandem mass spectrometry (LC‒MS/MS) was used as an initial method for identifying chemical compounds that were present in the drug sera. The prognostic DEGs were determined using univariate Cox regression analysis. The diagnostic value of the DEGs was estimated by constructing survival curves and utilizing the curved TCGA and GEO datasets, which are connected to alcoholic HCC according to their recipient operation characteristics (ROC). The affinity and stability between the target and predictive chemical compounds were checked by means of molecular docking and molecular dynamics simulations. Furthermore, the selected genes were subjected to clinical correlation analysis and KEGG analysis. The impact of PF on migration and cell proliferation was evaluated via western blotting.
Results: LC‒MS/MS revealed 68 components and identified 844 objects, 63 of which overlapped with the aims of patients with alcoholic HCC. Seven methods were used to determine that the ESR1 and CDK1 genes have advantages in the diagnosis of alcoholic HCC. Molecular docking and molecular dynamics demonstrated strong binding affinities between key components andESR1. Pathway analysis revealed that the two core genes were involved in apoptosis in a complex manner, with ESR1 showing enrichment in the chemogenic receptor activation pathway. The diagnostic significance of ESR1 was confirmed by Western blot and in vitro experiments.
Conclusion: PF inhibits the migration and proliferation of alcohol-related HCC cells by regulating the ESR1/ERK1/2 pathway to promote cell apoptosis.
Exploring the role of new angiogenic tracer, 68Ga-DOTAGA-IAC and comparison of its diagnostic performance with 18F-FDG PET/CT in patients with radioiodine refractory differentiated thyroid carcinoma
Authors: Kumar Srinivas Ananth , Sood Ashwani , Kumar Rajender , Shukla Jaya , Mittal Bhagwant Rai 
Published: June 2024

Abstract

Introduction: Integrin antagonist carbamate (IAC) – a newer αvβ3 integrin antagonist peptidomimetic molecule in the pipeline, has made the molecular imaging of tumour angiogenesis amenable. The study aims to investigate the biodistribution, clinical efficacy of 68Ga DOTAGA-IAC PET/CT in the detection of radioiodine refractory differentiated thyroid carcinoma (RAIR-DTC), to compare its diagnostic performance with the most commonly used imaging tool, 18F-FDG PET/CT.
Materials and methods: This prospective pilot study included RAIR-DTC patients who underwent whole-body 18F-FDG-PET/CT followed by 68Ga-DOTAGA-IAC PET/CT. For each patient, using organ specific circular regions of interest (ROIs) were evaluated in 16 anatomical structures on 68Ga-DOTAGA-IAC PET/CT to find out the biodistribution. A five-point grading system was proposed for the radiotracer uptake on 68Ga-DOTAGA-IAC PET/CT. Abnormal, non-physiologic radiotracer uptake (grade II and higher-grade lesions showing tracer uptake more than the mediastinal bloodpool) at a site congruous with disease activity was considered positive finding. The imaging findings of both the PET/CT were interpreted and quantitative parameters like SUVmax, MTV and TLG were obtained and statistically analyzed.
Results: For the biodistribution, maximum physiological tracer uptake was identified in the kidneys followed by spleen. 18F-FDG PET/CT detected 97 lesions (excluding the lung nodules) in 30 patients, majority of them being nodal lesions (73.2%) followed by skeletal lesions (15.5%). 68Ga-DOTAGA-IAC PET/CT detected 34 lesions (lung nodules were not taken into consideration similar to 18F-FDG PET/CT) in 14 patients. Out of the 34 lesions, 50% were nodal lesions. Few of the analysed patients had multiple grade lesions, with 20% of them having coexisting higher grade lesions (grade II and higher lesions) consistent with disease activity on 68Ga-DOTAGA-IAC PET/CT. The median SUVmax values of the lesions at all sites and volumetric parameters like median total MTV and TLG on FDG PET/CT outperformed IAC PET/CT.
Conclusion: Angiogenesis imaging with 68Ga-DOTAGA-IAC PET/CT appears to be inferior in the detection of lesions in patients with RAIR-DTC compared to 18F-FDG PET/CT, retaining the domination of FDG PET/CT imaging in clinical practice.
Heteronymous feedback from quadriceps onto soleus in stroke survivors
Authors: Cuadra Cristian , Wolf Steven L. , Lyle Mark A. 
Published: June 2024

Abstract

Background:
Recent findings suggest increased excitatory heteronymous feedback from quadriceps onto soleus may contribute to abnormal coactivation of knee and ankle extensors after stroke. However, there is lack of consensus on whether persons post-stroke exhibit altered heteronymous reflexes and, when present, the origin of increased excitation (i.e. increased excitation alone and/or decreased inhibition). This study examined heteronymous excitation and inhibition from quadriceps onto soleus in paretic, nonparetic, and age-matched control limbs to determine whether increased excitation was due to excitatory and/or reduced inhibitory reflex circuits. A secondary purpose was to examine whether heteronymous reflex magnitudes were related to clinical measures of lower limb recovery, walking-speed, and dynamic balance.
Methods:
Heteronymous excitation and inhibition from quadriceps onto soleus were examined in fourteen persons post-stroke and fourteen age-matched unimpaired participants. Heteronymous feedback was elicited by femoral nerve and quadriceps muscle stimulation in separate trials while participants tonically activated soleus at 20% max. Fugl-Myer assessment of lower extremity, 10-meter walk test, and Mini-BESTest were assessed in stroke survivors.
Results:
Heteronymous excitation and inhibition onsets, durations, and magnitudes were not different between paretic, nonparetic or age-matched unimpaired limbs. Quadriceps stimulation elicited excitation that was half the magnitude of femoral nerve stimulation. Femoral nerve elicited paretic limb heteronymous excitation was positively correlated with walking speed but did not reach significance because only a subset of paretic limbs exhibited excitation (n = 8, Spearman r = 0.69, P = 0.058).
Conclusions:
Heteronymous feedback from quadriceps onto soleus assessed in a seated posture was not impaired in persons post-stroke. Despite being unable to identify whether reduced inhibition contributes to abnormal excitation reported in prior studies, our results indicate quadriceps stimulation may allow a better estimate of heteronymous inhibition in those that exhibit exaggerated excitation. Heteronymous excitation magnitude in the paretic limb was positively correlated with self-selected walking speed suggesting paretic limb excitation at the higher end of a normal range may facilitate walking ability after stroke. Future studies are needed to identify whether heteronymous feedback from Q onto SOL is altered after stroke in upright postures and during motor tasks as a necessary next step to identify mechanisms underlying motor impairment.