bluuebunny/crossref_metadata_2025_split huggingface dataset:
The research on mechanism and prevention strategy of coal and gas outburst in normal faults based on support body model
Authors: Yang Gang , Song Dazhao , He Xueqiu , Zhang Jianguo , Qiu Liming , Guo Minggong , Zhao Yingjie 
Published: August 2024

Abstract

The depth of coal mining in China is increasing year by year, and the coal and gas outburst disaster is becoming more and more serious, which threatens the safe production of coal energy. Most of the coal and gas outburst sites occur near normal faults tectonic zone. In this paper, the evolution law of stress field and displacement field of driving face under different tectonic zone width of the normal fault was studied, and the support body model of normal fault coal and gas outburst was constructed, the occurrence mechanism of normal fault coal and gas outburst was revealed, and the prevention and control strategy of normal fault coal and gas outburst was put forwarded. The results show that the greater the width of the fault tectonic zone, the higher the horizontal stress of the driving face, the greater the deformation degree, and the higher the risk of coal and gas outburst. Based on the support body model, the criterion of coal and gas outburst induced by disturbance of normal fault is proposed, and the evolution process of coal and gas outburst from start to end of normal fault is revealed. Using the microseismic and electromagnetic radiation to monitor the normal fault area, it is found that the fracture frequency and stress of coal rock in the normal fault area are significantly higher than those in the non-fault area, and the stress of fault hanging wall is higher than that of fault footwall. The prevention and control of coal and gas outburst in normal fault tectonic zone should be started from two aspects: eliminating the energy storage body and improving the supporting ability of tectonic zone. The research results provide a new strategy for the prevention and control of coal and gas outburst in fault zones.
MLKL are involved in the regulation of skin wound healing and the interplay between macrophages and myofibroblasts
Authors: Zhao Jiamin , Zhang Shuangyi , Bai Yunjie , Gong Zhiguo , Bao Wenhui , Yu Zhuoya , Liu Bo , Mao Wei , Hasi Surong 
Published: August 2024

Abstract

The pseudokinase mixed lineage kinase domain-like protein (MLKL) acts as a crucial effector in the necroptosis pathway. It is widely recognized that MLKL-dependent necrosis is closely related to inflammation in wound healing, which contributes to detrimental pathologies. In present study, transcriptome sequencing data indicate sustained overexpression of MLKL throughout the wound healing process, extending beyond the early inflammation phase. In vivo experiments clearly demonstrate that MLKL deficiency delays skin wound healing, as evidenced by morphological observations and pathological characteristics. MLKL deficiency impairs the synthesis of inflammatory factors (IL-6, TNF-α, and PGE2) and tissue repair-related molecules (EGF, VEGF, ERα, and MMP-9) at the wound site, potentially leading to delayed wound closure. Furthermore, we have identified the roles of MLKL and PGE2 in the interaction between macrophages (both classically activated and alternatively activated) and myofibroblasts, an interaction essential at each stage of wound healing. Our findings suggest that MLKL's involvement in wound healing may not solely rely on necrosis-induced inflammatory responses during the early stages but also contributes to other activities in tissue regeneration.
Expression of genes involved in insulin metabolism in subcutaneous adipose tissue of pregnant women with and without polycystic ovary syndrome (PCOS)
Authors: Alvandi Shirin Joodi , Ghoraeian Pegah , Alizadeh Alireza , Aghajanpour Sama , Emami Neda , Moini Ashraf , Shahhoseini Maryam , Schmutzler Andreas , Hafezi Maryam 
Published: August 2024

Abstract

Background
The qualitative analysis of adipose tissue (AT) is an exciting area for research and clinical applications in several diseases and it is emerging along with the approach to research on women with polycystic ovary syndrome (PCOS). PCOS is a common disorder in women of reproductive age, which is associated with dysfunction of AT. The aim of study was comparing the expression of genes involved in insulin metabolism in the subcutaneous adipose tissue (SAT) of pregnant women with and without PCOS.
Methods
In a case-control study, after cesarean section, SAT was taken from two groups of women with PCOS (n = 12) and without PCOS (non-PCOS;n = 24) (2:1 ratio control: case). Then the relative expression of Insulin receptor substrate 1 and 2 (IRS1, IRS2), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and phosphatidylinositol-4, 5-bisphosphate3-kinasecatalytic subunit alpha (PIK3CA) were measured using Real-time qPCR.
Results
No significant difference was observed in terms of age, pre-pregnancy BMI and BMI on the day of delivery between PCOS and non-PCOS groups. The mRNA levels of IRS1, IRS2, PIK3R1 and PIK3CA in the SAT of pregnant women with PCOS showed a significant decrease compared to non-PCOS pregnant women (P < 0.0001).
Conclusion
This is the first study in humans that investigated gene expression involved in insulin metabolism in subcutaneous AT of pregnant women with and without PCOS. Overall, dramatically decrease in mRNA abundance of IRS1, IRS2, PIK3R1 and PIK3CA in age and BMI-matched case and control groups, proposing the possible central role of AT for insulin metabolism in women suffering from PCOS during pregnancy and around parturition. Given that mRNA may not be directly proportional to the expression level of the proteins, further studies are warranted to elucidate the protein expression of selected factors in response to PCOS in pregnant women with PCOS.
Trial registration:
not applicable
Genome-wide and candidate gene association mapping for plant height in wheat
Authors: Suleman Hafiz Muhammad , Qayyum Humaira , ur-Rehman Sana , Majeed Khawar , Mukhtar Misbah , Zulfiqar Saima , Mahmood Zahid , Aziz Abdul , Fayyaz Muhammad , Cao Shuanghe , Rasheed Awais , He Zhonghu 
Published: August 2024

Abstract

Plant architecture and yield potential of wheat are significantly influenced by the plant height (PH). In the present study, a diversity panel consisting of 199 historical wheat cultivars of Pakistan was evaluated for PH in three environments, and a genome-wide association study (GWAS) was conducted to identify loci associated with reduced height. GWAS identified 19 loci that were associated with reduced height, out of which 12 loci were consistently identified in all environments. Allelic variations were analyzed in the diversity panel for five Rht genes including Rht-B1, Rht-D1, Rht13, Rht25, and Rht26 using diagnostic KASP markers. Furthermore, a KASP marker was developed for the identification of dwarfing allele Rht-B1p in wheat. Allelic frequency of the GA-insensitive dwarfing allele Rht-B1b was pre-dominant (69.6%) followed by the GA-sensitive Rht26 mutant allele (58.5%). Five dwarfing allele of Rht25 including Rht25c, Rht25d, and Rht25e were rarely present in the cultivars with a frequency of 1.5%, 1%, 0.5%, respectively. The use of alternate dwarfing alleles to reduce PH can increase the genetic base of wheat cultivars by removing selection pressure on Rht-B1b/Rht-D1b haplotype and can lead to the development of wheat cultivars with improved characteristics such as reduced lodging risk, increased resource allocation to grain, improved harvest efficiency, enhanced crop stability, and adaptability.
LncRNA-MEG3 mediated diabetic cerebral ischemic reperfusion injury-induced apoptosis via modulating interaction between Annexin A2 and Akt in mitochondria
Authors: Zhou Wanqing , Tan Chongyi , Xiong Di , Chen Cheng , Zhao Yanfei , Xie Yongqiu , Sun Bei , Wang Zhihua , Xia Pingping , Ye Zhi 
Published: August 2024

Abstract

Within clinical domains, encompassing neurosurgery and macrovascular cardiac procedures, certain interventions result in cerebral ischemic reperfusion injury (CIRI). Diabetes mellitus (DM) increases the risk of CIRI and worsens the severity of neurological impairment. It was documented that lncRNA-MEG3 contributed to the pathogenesis of CIRI. However, the pivotal significance of lncRNA-MEG3 in diabetic CIRI has never been studied. Firstly, diabetics or non-diabetics with acute ischemic stroke (AIS), as well as diabetics and controls were enrolled. LncRNA-MEG3 expression in DM + AIS cases was remarkably higher than that in cases with AIS and healthy controls. Moreover, lncRNA-MEG3 expression was strongly linked to the NIHSS. Additionally, our findings unveiled that lncRNA-MEG3 depletion alleviated neurological impairments following CIRI in diabetic rats, and cellular death resulted from OGD plus hyperglycemic reperfusion in rat brain microvascular endothelial cells (RBMVECs) that was concomitant with the increased phosphorylation of Annexin A2 (Anxa2) at Tyr23. Meanwhile, over-expression of Anxa2, identified as a lncRNA-MEG3-associated mitochondrial protein, significantly ablated mitochondria-derived apoptosis. Importantly, lncRNA-MEG3 knockdown enhanced the mitochondrial translocation of Anxa2 via promoting its phosphorylation at Tyr23 in OGD + HG-treated RBMVECs. Furthermore, Anxa2 enhanced Akt phosphorylation at Ser473 and bound to Akt in mitochondria, which was involved in lncRNA-MEG3 depletion-induced neuroprotection. However, lncRNA-MEG3 mobilized to mitochondria in Plectin-dependent manner and subsequently impeded the interaction between p-Anxa2 and p-Akt. The outcomes provided clinical evidence that lncRNA-MEG3 appeared as an unfavorable prognostic factor for diabetic CIRI and revealed that lncRNA-MEG3 knockdown could be protective against diabetic CIRI-induced mitochondria-related apoptosis through modulating Anxa2 binding to Akt in mitochondria.
Protected Landscape with Natural Habitat inside Urban Area Could Conserve Avifauna Biodiversity: A Long-term Study from an Overpopulated Subtropical Megacity
Authors: Shome Ashikur Rahman , Rabbe Md. Fazle , Jaman Mohammad Firoj , Khan Nahla , Islam Md. Aminul , Alam Md. Mahabub 
Published: August 2024

Abstract

Natural habitats were converted to human-modified landscape as a result of urbanizations in metropolitan areas which resulting in alteration of avian species composition. Analyzing bird habitat preferences and seasonal dynamics can help us better understand how they adapt to changing environments. We used the point count approach at Bangladesh's National Botanical Garden to gain a thorough picture of how a protected landscape playing role in avian biodiversity conservation in a mega-populated, highly polluted city with experienced with extremely modified natural habitat. Along with impacts of habitat heterogeneity and temporal changes on avian community composition was also detected for this three years long survey. Observations based on habitat and seasonal trends revealed a diverse avifauna with 133 bird species (about 20 percent of the country's avifauna) and 5931 individuals belonging to 16 orders and 46 families. Richness and abundance of birds varied significantly among the habitats and season types. The highest richness, abundance and diversity indices was calculated for tree (H = 3.645, D = 0.966) and the pair-wise ANOVA test for habitats was significant only for tree. Red-vented Bulbul Pycnonotus cafer ranked as the most abundant species and we found seven generalist species based on their habitat preferences. Bird assemblages were richer in winter showed significant variation in pair-wise ANOVA test. Although bird diversity was found maximum in winter (H = 3.935, D = 0.976), evenness was calculated the highest for rainy season (E = 0.711). The findings of this study demonstrated that bird variety is strongly linked to their various habitats and seasons. Avifaunal persistence was aided by habitat heterogeneity, which provided optimal foraging, roosting, and breeding options for birds. Diverse type of native plantations habitat and wetlands with natural habitat could aid in conservation of avian communities in urban area. The diversity of bird species revealed the ecosystems' intactness and ecological soundness. This finding provides the foundation for a long-term study of the bird-habitat connection and seasonal fluctuations.
Development and validation of a predictive model for increased drainage after open transforaminal lumbar posterior fusion
Authors: Han Kangen , Li Yu , Gu Hongwen , Hu Yin , Tang Shilei , Zhang Zhihao , Yu Hailong , Wang Hongwei 
Published: August 2024

Abstract

Objective
This study aims to investigate the risk factors associated with increased drainage volume following open transforaminal lumbar interbody fusion (TLIF) surgery and to develop and validate a predictive model.
Methods
We collected clinical data from 795 patients who underwent open TLIF at the Northern Theater Command General Hospital between January 2016 and December 2020. These patients were randomly divided into a training group (n = 557) and a validation group (n = 238), with no significant statistical difference between the groups (p > 0.05). Using variables selected via LASSO regression analysis, we constructed a multivariable logistic regression prediction model and developed a corresponding nomogram. The model's performance was internally validated using ROC curves, the Hosmer-Lemeshow goodness-of-fit test, and calibration curves. Its clinical utility was assessed using Decision Curve Analysis (DCA).
Results
Four predictive variables were identified through LASSO regression analysis: age, surgical segment, duration of surgery, and intraoperative blood loss. The ROC curve demonstrated that the model possesses excellent discriminative ability. Additionally, the Hosher-Lemeshow test and calibration curves indicated that the model's predicted probabilities align closely with actual outcomes, showing high calibration accuracy. The DCA confirmed the clinical utility of the predictive model, establishing its suitability for clinical application.
Conclusion
The risk factors for increased drainage volume post-open TLIF include age, surgical segment, duration of surgery, and intraoperative blood loss. The validation confirms that the constructed predictive model is robust and can be effectively applied in clinical settings.
First account of vivipary, including physical and chemical attributes, in fruits of Cereus hildmannianus K. Schum. (Cactaceae)
Authors: Santos Everaldo dos , Luz Gilberto Codignole , Mangolim Claudete , Machado María de Fátima Pires da Silva , Cota-Sanchez J. Hugo 
Published: August 2024

Abstract

The basic aspects of vivipary, precocious germination within the fruit, are known. Consequently, research on this topic in the Cactaceae has increased in the last two decades and becoming more diversified. The family is amongst the most viviparous-rich angiosperm families together with some mangrove lineages. In this paper we report a new case of facultative vivipary, specifically cryptovivipary, in Cereus hildmannianus, a South American columnar species and expand aspects regarding the physico-chemical traits of its fruits. The goals of this investigation were to: 1) report the first occurrence of vivipary in this species and characteristics of viviparous seedlings, and 2) describe some of the physical and chemical attributes of viviparous and non-viviparous fruits, such as size, weight, color, and total soluble solids (°Brix). Our findings show that this is third account in Cereus, for a 3% vivipary at the generic level. This discovery increases to 78 viviparous species for an overall 5.4% of viviparity family wide. Generally, the number and percentage of vivipary was low, with an average of 22.3 viviparous seedlings from an average of 1319 ungerminated seeds (= 1.7% vivipary/fruit). Statistical analyses indicate that non-viviparous fruits are larger, heavier, have higher content of soluble solids, thicker and brighter pericarp, and more seeds. Agriculturally, these attributes are more appealing to consumers suggesting that normal, non-viviparous fruits, are commercially more desirable; hence, vivipary is a detrimental character in fruit crops.
Declined intrinsic capacity and its influencing factors among older adults in China: a national cross-sectional survey
Authors: Fang Ying , Wang Ruilong , Qing Yanhua , Zou Guanyang , Zhang Caixia 
Published: August 2024

Abstract

Background
The decline in intrinsic capacity (IC) among older adults is a significant global health challenge, impacting their well-being and quality of life. Despite global efforts to promote healthy aging, research on factors contributing to IC decline in the Chinese population is limited. This study aims to investigate the decline of intrinsic capacity in Chinese older adults and to explore the influence of sociodemographic, health status, and lifestyle factors on the decline of intrinsic capacity.
Methods
Prevalence of intrinsic capacity decline was described using frequency analysis, while chi-square tests were used to analyze its associations with sociodemographic characteristics, health status, and lifestyle factors. Binary logistic regression analysis was used to identify significant factors influencing the decline of intrinsic capacity (α = 0.05).
Results
Among 6,941 respondents aged 60 years and above, 83.8% reported a decline in intrinsic capacity. Cognitive impairment was predominant (71.8%), followed by psychological (40.4%), locomotion (19.8%), vitality (17.2%), and sensory impairments (8.9%). Sociodemographic factors associated with a decline in intrinsic capacity included female gender, age 80 and older, unmarried, divorced or widowed status, rural residence, low education, and lack of health or pension insurance (p < 0.05). From the perspective of health status, factors associated with higher rates of intrinsic capacity decline include poor self-rated health, multiple chronic conditions, recent falls, frequent physical pain, recent outpatient visits, hospitalizations, and pessimistic life expectancy (p < 0.05). Lifestyle factors such as alcohol consumption, lack of social participation, prolonged sleep duration, and no Internet use were also linked to higher rates of intrinsic capacity decline (p < 0.05). The results of the binary logistic regression indicated that age, marital status, residence address, education level, pension insurance status, self-rated health, the presence of multiple chronic conditions, frequency of perceived physical pain, subjective life expectancy, social participation, sleep duration, and Internet access significantly influenced the decline of intrinsic capacity in older adults (p < 0.05).
Conclusions
The decline in intrinsic capacity among older adults in China, particularly in cognitive impairment, is concerning. Targeted interventions are necessary for vulnerable populations, especially those who are older, divorced or widowed, living in rural areas, or have lower education levels. Enhancing social pensions, promoting social participation, encouraging healthy sleep patterns, and improving digital inclusion to improve intrinsic capacity among older adults is important.
“I have never heard them say, ‘For those women who were already tested, they should go for blood testing again." Prevalence and factors associated with uptake of repeat HIV testing among pregnant women in Blantyre, Malawi
Authors: Chikalipo Maria Chifuniro , Kaula Martha Patience , Mwapasa Victor , Nyondo-Mipando Alinane Linda 
Published: August 2024

Abstract

Repeat HIV testing during pregnancy is significant to detect new maternal HIV infections and mitigate the risk of mother-to-child HIV transmission. Despite guidelines advocating retesting of initially HIV-negative pregnant women, there is limited information on the implementation of these recommendations. Methods We conducted a convergent parallel mixed method study from November 2021 to April 2022 to determine the prevalence and associated factors for a repeat HIV test among women in the third trimester from Ndirande and Lirangwe primary health facilities in Blantyre. Our quantitative approach involved a retrospective review of antenatal records from July 2019 to June 2020. STATA version 14 was used for descriptive analysis. Frequency distributions, fisher’s tests and multivariable logistic regressions were used to examine the association between repeat HIV testing and selected explanatory variables. The qualitative component was exploratory following phenomenological design. Data were collected from 44 pregnant women and 10 health workers who were purposively selected through focus group discussions in-depth and key informant interviews. Transcripts were coded deductively and inductively manually. The thematic analysis of the data was informed by the Consolidated Framework for Implementation Research (CFIR). Results Analysis of 369 antenatal records, with 302 from Ndirande and 67 from Lirangwe, revealed that only 30 (8.13%) participants received a repeat HIV test in the third trimester from both facilities. Increasing age reduced the likelihood of accessing repeat HIV testing in the third trimester compared to younger women (OR = 0.43; 95% CI: 0.05–3.86). Age, gravidity, and parity did not significantly impact the probability of retesting. Key factors impeding repeat HIV testing included unfamiliarity with the intervention, inadequate resources and clinic operations. In contrast, confirmation of HIV status and improved neonatal outcomes were motivators for repeat HIV testing. Conclusion. Information and counselling on the benefits of repeat HIV testing later in pregnancy is key in increasing uptake and implementation of the service in future pregnancies. In addition, integration of services should be emphasized to improve clinic operations which are vital in the implementation and uptake of repeat HIV testing among pregnant women.
Development of an ethical framework for the use of social robots in the care of individuals with major neurocognitive disorders: A qualitative study
Authors: Ware Caitlin , Rigaud Anne-Sophie , Blavette Lauriane , Damnée Souad , Dacunha Sebastien , Lenoir Hermine , Piccoli Mattieu , Cristancho-Lacroix Victoria , Pino Maribel 
Published: August 2024

Abstract

Background
Despite the growing use of social robots in geriatric care, there is a lack of standardized ethical guidelines to inform and guide professionals in their implementation.
Objective
This study has two main objectives: 1) to understand how professionals conducting social robot interventions (SRIs) perceive and approach the ethical issues linked to the use of social robots with older adults and 2) to establish ethical guidelines to help professionals carry out SRIs with older adults.
Methods
For this descriptive qualitative study, we conducted interviews with 20 healthcare professionals working in geriatric facilities. The interviews were recorded and transcribed, and a content analysis was performed to identify certain themes and recommendations concerning the use of social robots with older adults.
Results
Three main themes emerged from the analysis of the interviews: the clear and direct presentation of the robot, obtaining consent from the beneficiary concerning its use, and the emphasis on human contact in robot-mediated interventions. Additionally, the following subthemes were evoked: imposed social robotic use, extra time and effort, careful selection of beneficiaries for robotic therapy, adaptability, technical problems, and the need for guidelines and training in ethical social robot use.
Conclusion
The use of social robots should be guided by the same ethical guidelines followed in all therapeutic interventions; however, healthcare professionals express a need for special training and preparation for SRIs in geriatric settings. We have drafted several preliminary recommendations for carrying out SRIs with older adults. Future research should focus on standardizing guidelines and creating an accessible format for training.
Trial Registration:
IRB N°: 00012021-110