bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra‐Tough Copper–Copper Bonding by Nano‐Oxide‐Dispersed Copper Nanomembranes
Authors: Teng Yun , Zhu Wenqing , Wang Qing , Zhang Zhibo , Wang Hang , Guo Baisong , Yang Ziyin , Gong Hao , He Chuan , Qu Boxi , Feng Shien‐Ping , Yang Yong 
Published: February 2025

AbstractMetal–metal bonding has played a pivotal role in advancing human technologies across various industrial sectors. As devices continue to miniaturize, there is an increasing need for efficient bonding techniques capable of achieving metal–metal bonds at smaller length scales. In this study, a facile but effective bonding technique is developed that enables the bonding of randomly oriented copper with copper nanomembranes under low temperatures and pressures. The fabricated copper nanomembranes, with a thickness of ≈50 nm and a width of 1 cm or above, exhibit a unique heterogeneous nanostructure, comprising copper nanocrystals along with nano‐copper‐oxide dispersions. Consequently, these copper nanomembranes display exceptional mechanical properties, including an ultra‐low elastic modulus of ≈35 GPa, a remarkable yield strength of ≈1 GPa, and excellent ductility of ≈40%, overcoming the conventional strength‐ductility trade‐off observed in various copper alloys. Most importantly, these ultra‐soft copper nanomembranes serve as metallic “glues”, promoting grain growth across the bonding interface between randomly oriented copper surfaces. This process leads to an average interfacial shear strength of up to 73 MPa at room temperature, representing an approximate 35 times increase in bonding strength compared to direct copper–copper bonding achieved under identical temperature and pressure conditions.
Adaptive Deployable Structure Enabled by Actively Controlled Tensegrity for Space Debris Removal
Authors: Shang Endong , Li Ao , Islam Md Shariful , Zhang Li‐Yuan , Cao Changyong (Chase) 
Published: February 2025

AbstractThe Earth's orbital environment is increasingly congested with space debris, posing a substantial risk to space operations and safety. Current mitigation strategies are primarily tailored to either small debris, through protective devices, or large debris, via spacecraft deorbiting methods, leaving medium‐sized debris (0.4–10 cm) as a significant unaddressed threat. This study introduces an innovative adaptive deployable structure, utilizing actively controlled tensegrity, designed specifically for the removal of medium debris. The basic configuration and deployment process of the structure is detailed, followed by an analysis of key structural parameters affecting its folding and deployment performance. Additionally, the load‐bearing capacity and impact resistance of the structure when integrated with a mesh fabric are evaluated. The optimal parameters and morphology for effective debris removal are identified, culminating in the construction of a 1:20 scale prototype for experimental validation. This structure not only adapts its configuration based on operational needs but also withstands impacts from space debris, thereby playing a crucial role in enhancing orbital safety.
Multifunctional Boron‐based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators
Authors: Xu Changyi , Liu Ming , Xie Xinran , Li Zhixin , Zhu Yuefei , Ye Yang , Du Mengya , Hu Suhua , Liu Tianrun , Guo Yubiao , Wen Weiping , Liu Huanliang , Tu Zhaoxu 
Published: February 2025

AbstractEffective management of serious respiratory diseases, such as asthma and recalcitrant rhinitis, remains a global challenge. Here, it is shown that induced sputum supernatants (ISS) from patients with asthma contain higher levels of cell‐free DNA (cfDNA) compared to that of healthy volunteers. Although cfDNA scavenging strategies have been developed for inflammation modulation in previous studies, this fall short in clinical settings due to the excessive neutrophil extracellular trap (NET) formation, reactive oxygen and nitrogen species (RONS) and bacterial infections in injured airway tissues. Based on this, a multifunctional boron‐based 2D nanoplatform B‐PM is designed by coating boron nanosheets (B‐NS) with polyamidoamine generation 1 (PG1) dendrimer, which can simultaneously target cfDNA, NETs, RONS, and bacteria. The effects of B‐PM in promoting mucosal repair, reducing airway inflammation, and mucus production have been demonstrated in model mice, and the therapeutic effect is superior to dexamethasone. Furthermore, flow cytometry with clustering analysis and transcriptome analysis with RNA‐sequencing are adopted to comprehensively evaluate the in vivo anti‐inflammation therapeutic effects. These findings emphasize the significance of a multi‐targeting strategy to modulate dysregulated inflammation and highlight multifunctional boron‐based 2D nanoplatforms for the amelioration of respiratory inflammatory diseases.
4D Assembly of Time‐dependent Lanthanide Supramolecular Multicolor Phosphorescence for Encryption and Visual Sensing
Authors: Wu Yun‐Ga , Zhou Wei‐Lei , Qiu Yugui , Wang Siwei , Liu Jinglin , Chen Yong , Xu Xiufang , Liu Yu 
Published: February 2025

AbstractSupramolecular dynamic room temperature phosphorescence (RTP) is the focus of current research because of its wide application in biological imaging and information anti‐counterfeiting. Herein, a time‐dependent supramolecular lanthanide phosphorescent 4D assembly material with multicolor luminescence including white, which is composed of 4‐(4‐bromophenyl)‐pyridine salt derivative (G), inorganic clay (LP)/Eu complex and pyridine dicarboxylic acid (DPA) is reported. Compared with the self‐assembled nanoparticle G, the lamellar assembly G/LP showed the double emission of fluorescence at 380 nm and phosphorescence at 516 nm over time. Within 60 min, the phosphorescence lifetime and the quantum yield increases from none to 7.4 ms and 27.53% respectively, achieving the time‐dependent phosphorescence emission, due to the limitation of progressive stacking of LP electrostatically driven “domino effect.” Furthermore, the 4D assembly of DPA and G/LP/Eu leads to a time‐resolved multicolor emission from colorless to purple to white, which is successfully applied to information multi‐level logic anti‐counterfeiting and efficiently antibiotic selective sensor.
Honokiol‐Magnolol‐Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti‐PD‐1 Immunotherapy in Colorectal Cancer by Triggering GSDME‐Dependent Pyroptosis
Authors: Gao Quan , Sheng Qinsong , Yang Zijing , Zhu ZhiYu , Li Lin , Xu Lihui , Xia Jing , Qiao Yunhao , Gu Jie , Zhu Xiaolong , Xie Tian , Sui Xinbing 
Published: February 2025

AbstractSignificant progress is made in the treatment of metastatic colorectal cancer (mCRC) patients, however, therapeutic options remain limited for patients with mCRC. In recent years, traditional Chinese medicine (TCM) has gained significant attention. Among these, Huangqin Houpo decoction has demonstrated efficacy in mCRC treatment. Despite its promise, the active ingredients and mechanisms underlying its anticancer effects remain unclear. Using integrative pharmacological approaches, six compounds are identified as the primary active ingredients in Huangqin Houpo decoction. Among them, honokiol (H), magnolol (M), and baicalin (B) are found to exhibit a synergistic anticancer effect on CRC. The HMB combination significantly outperforms mono‐ or bi‐agent treatments in reducing tumor growth. Furthermore, the anticancer efficacy of the HMB combination surpasses that of medium‐ and high‐dose Huangqin Houpo decoction and the FOLFOX regimen. Notably, HMB is comparable in efficacy to the FOLFOIRI regimen. Most importantly, HMB is shown to enhance the sensitivity of CRC cells to anti‐PD‐1 immunotherapy in vivo. Mechanistic studies reveal that the HMB combination exerts its synergistic anticancer effects and enhances anti‐PD‐1 immunotherapy by inducing GSDME‐dependent pyroptosis. Our study will hopefully provide a potential therapeutic strategy for mCRC patients in the future.
Mitoxantrone‐Encapsulated ZIF‐8 Enhances Chemo‐Immunotherapy via Amplified Immunogenic Cell Death
Authors: Li Junhong , Lv Wenxing , Han Ziwei , Li Yike , Deng Jinqi , Huang Yanjuan , Wan Shuo , Sun Jiashu , Dai Bo 
Published: February 2025

AbstractChemo‐immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of immune responses and systemic immune toxicity have hindered its clinical applications. Here, a zeolite imidazolate framework‐8 (ZIF‐8) that encapsulates mitoxantrone (MIT), an immune cell death (ICD)‐inducing chemotherapeutic agent (MIT@ZIF‐8), is synthesized using a one‐pot aqueous‐phase process. ZIF‐8 serves as a dual‐functional nanomaterial for chemo‐immunotherapy: a carrier to enhance tumor uptake of MIT for improved chemotherapy efficacy, and a pyroptosis inducer to amplify MIT‐induced ICD for augmented anti‐tumor immune responses. As a result, in vivo administration of MIT@ZIF‐8 markedly inhibits tumor growth in both immunologically “hot” colon cancer and immunologically “cold” prostate cancer. Moreover, MIT@ZIF‐8 treatment increases the abundance of cytotoxic CD8+ T cells and reduces the amount of immunosuppressive regulatory T cells in tumors, thereby enhancing anti‐tumor immunity and sensitizing prostate cancer to anti‐CTLA‐4 immunotherapy. In summary, MIT@ZIF‐8 offers a highly translational approach for chemo‐immunotherapy.
Evolutionary Perspectives, Comparative Approaches, and the Lived Experience of Menopause
Authors: Sievert Lynnette Leidy 
Published: February 2025

ABSTRACTThe purpose of this synthesis is to review age at menopause, symptom experience at midlife, and the evolution of menopause in a way that is helpful for biological anthropologists who are interested in the study of this challenging time of life. The synthesis begins with the biology of menopause, then shifts to the evolution of menopause with an emphasis on phylogenetic and adaptationist perspectives. Discussion of the biology and evolution of menopause incorporates a cross‐species perspective, with particular attention to whales and primates. The synthesis continues with a cross‐population review of variation in age at menopause. The final section is about symptom experience across populations with attention to the medical context of midlife, a focus on hot flashes, and consideration of the strengths and limitations of ethnographic and questionnaire‐based research. The review ends with suggestions for where biological anthropology can make important contributions to the research of midlife and menopause.
From the Design of LIonomers to the Development of Maleic Anhydride‐Grafted‐Polypropylene (PPgMA) Microcellular Foams
Authors: Hou Liutong , Gérard Jean‐François , Livi Sébastien , Duchet‐Rumeau Jannick 
Published: February 2025

ABSTRACTIn this paper, a new route is reported to design ionic liquid branched polypropylene (PP) from the reaction of 1‐aminoethyl‐3‐methylimidazolium bromide ([AEMIM] Br) and maleic anhydride grafted‐PP (PPgMA). Therefore, LIonomers, the 2.0 generation of ionomers, have been obtained. Series of LIonomers with different structures and morphologies are prepared via (i) tuning maleic anhydride (MA) and [AEMIM] Br contents, (ii) dispersion of ionic liquid, and (iii) the ionic liquids branches assembling. The microstructure especially the location and assembling of grafted [AEMIM] Br is determined by exploring the relaxation behavior of the materials. Thus, a significant increase of the melt viscosity resulting from the ionic interactions between ionic liquid branches is evidenced by shear rheology. As a consequence, foaming behavior of the neat PP and LIonomers are investigated by using supercritical carbon dioxide (scCO2) as foaming agent. All LIonomers show significantly improved foamability (expansion ratio, cell diameter, cell density and porosity) and compressive properties. These ones are mainly controlled by the assembling of ionic branches for LIonomers leading to a size of the ionic rich domains of about 60 μm. This phenomenon is attributed to the good compromise between rheological behavior and interactions established with CO2.
Composites With Epoxy‐Modified Waterborne Polyurethane Sizing Agents Enhance Mechanical and Thermal Properties
Authors: Song Shuoyao , Wu Dongliang , Xing Yuxuan , Qin Xuhao , Liu Xiaodong , Hu Chuanxiu , Ma Zhikai , Du Songyan , Liu Lei , Zhang Ruliang 
Published: February 2025

ABSTRACTThe interface is critical to the mechanical properties of carbon fiber‐reinforced polymer (CFRP) composites. This research introduced a range of epoxy‐modified waterborne polyurethane (WEPU) sizing agents to improve both the mechanical performance and interfacial properties of composites. The investigation focused on the effect of different sizing agent concentrations and the amount of epoxy resin added on the mechanical properties of the composites. In particular, 1.5% concentration of the WEPU‐4% agent provided the most significant improvement in CFRP interfacial strength. Carbon fiber (CF) treated with this agent exhibited a tensile strength of 3.27GPa, an increase of 6.58%. The contact angle between the fiber and epoxy was reduced from 54° to 48°, improving the wettability of the resin on the CF surface. In addition, the interlaminar shear strength (ILSS) of the composites increased to 79.09 MPa, an improvement of 37.29%. This study provides an efficient and effective approach to WPU modification that significantly improves the interfacial performance at the CF–resin interface. The sizing agent synthesis is straightforward and efficient, in line with contemporary principles of environmental sustainability.
Magnetite‐Functionalized Molecularly Imprinted Polymer for Selective Removal of Dimethyl Phthalate
Authors: Andreas Andreas , Fauzia Syiffa , Aristiawan Yosi , Muzdalifah Dian , Sari Septia Ratna 
Published: February 2025

ABSTRACTDimethyl phthalate (DMP), a plasticizer, causes several health issues and is dangerous for the environment. Thus, recent work has investigated a selective method, molecularly imprinted polymer (MIP), for DMP removal. MIP was synthesized via radical polymerization (bulk polymerization). The ratio of template to monomer was 1:4 mmol. A non‐imprinted polymer (MNIP) was prepared for comparison as well. The Fourier transform infrared (FTIR) spectrum showed a Si‐O‐Si bond at 1100–1050 cm−1 and a Fe‐O bond at 567.07 cm−1 indicating Fe3O4 has been successfully covered by SiO2. The DMP was characterized by the vibration of O‐H at wavenumber 1111–1151.50 cm−1 for MMIP. Scanning electron microscopy (SEM) indicated a spherical‐like particle of MMIP. Meanwhile, MNIP has a rough surface with uniform particles. The particle sizes of MMIP and MNIP were 2.675 and 2.231 nm, respectively. The optimum conditions were achieved at pH 9, contact time 60 min with adsorption capacity 175.60 μg/mg for MMIP and 172.41 μg/mg for MNIP. The percent efficiency of MMIP for DMP recognition in river water was 97.20%. The adsorption of DMP onto MMIP and MNIP obeyed the Langmuir isotherm and the pseudo‐second‐order model, denoting a chemical monolayer adsorption process through hydrogen bonding.
Natürliche Recarbonatisierung von Kalksandstein: Ein neuer Ansatz zur Bewertung der Nachhaltigkeit
Authors: Eden Wolfgang , Fouad Nabil A. , Istanbuly Zakaria 
Published: February 2025

AbstractDie Recarbonatisierung von Kalksandstein stellt einen natürlichen Prozess dar, bei dem während der Nutzungsphase die bei der Autoklavierung gebildeten Calcium‐Silikathydrate (CSH‐Phasen) CO2 aus der Umgebungsluft absorbieren. Der vorliegende Beitrag präsentiert die Ergebnisse umfassender Untersuchungen zur Recarbonatisierung von Kalksandstein, die im Zeitraum von 2021 bis 2024 an 76 repräsentativen Proben mittels chemisch‐mineralogischer Analysen durchgeführt wurden. Eine zentrale Erkenntnis dieser Untersuchungen ist, dass eine Tonne Kalksandstein etwa 50 kg CO2 dauerhaft binden kann. Die Recarbonatisierung verläuft allmählich von außen nach innen in das Kalksandsteinmaterial hinein und wird innerhalb eines Zeitraums von 50 Jahren vollständig abgeschlossen. Darüber hinaus wird in diesem Beitrag ein neuartiger Berechnungsansatz vorgestellt, der eine Quantifizierung und Bewertung der Nachhaltigkeit von Kalksandstein ermöglicht. Neben der Integration ökologischer, ökonomischer und technischer Parameter wird durch diesen Ansatz auch eine fundierte Prognose der durch Recarbonatisierung gebundenen CO2‐Mengen über definierte Zeiträume hinweg ermöglicht.
Bildgebende Schlierenverfahren zur Visualisierung von Raumluftströmungen in der Bauphysik
Authors: Benetas Lia , Wakoya Gena Amayu , Alsaad Hayder , Völker Conrad 
Published: February 2025

AbstractZur Visualisierung und Messung von Luftströmungen werden oft invasive Verfahren angewendet, welche die Strömung durch das Einbringen von Sensoren (bspw. Anemometer) oder Partikeln (bspw. Particle Image Velocimetry) beeinflussen. Alternativen bilden die Schlierenverfahren, namentlich das optische Schlierenverfahren mit Schlierenspiegel sowie das Background‐Oriented Schlierenverfahren (BOS), die an der Professur Bauphysik der Bauhaus‐Universität Weimar insbesondere zur Visualisierung von Raumluftströmungen optimiert wurden. Beide Verfahren arbeiten nicht‐invasiv und visualisieren Luftströmungen, die auf Dichtegradienten im Medium beruhen. Folgend werden beide Verfahren sowie verschiedene Anwendungen und Möglichkeiten zur quantitativen Auswertung vorgestellt. Die dargestellten Studien beleuchten Strömungen, die sowohl aus natürlicher wie auch erzwungener Konvektion resultieren und reichen von der Visualisierung personalisierter Lüftungssysteme über das Mikroklima des Menschen einschließlich der Ausbreitung der Atemluft in verschiedenen Szenarien (u. a. Tragen verschiedener Mund‐Nase‐Bedeckungen, beim Blasinstrumentenspiel und Singen, bei sportlicher Betätigung und nasaler Highflow‐Therapie) bis hin zur Untersuchung des Mikroklimas verschiedener Forschungsgegenstände (Betonzylinder und Globe‐Thermometer). Es wird angeregt, die Schlierenverfahren anzuwenden, um Raumluftströmungen in weiteren bauphysikalischen und angrenzenden Fachgebieten holistisch zu untersuchen.
Flüssigkunststoff‐Abdichtung für befahrbare Holzkonstruktionen: Alterung und Zugeigenschaften
Authors: Wick Adrian , Volkmer Thomas , Übelhör Dirk 
Published: February 2025

AbstractBefahrbare Holzdeckkonstruktionen findet man in der Form von Fußgänger‐ und Fahrradbrücken sowie Verkehrsflächen von Parkhäusern oder Autobrücken. Zu Gewährleistung einer langfristigen Funktionstüchtigkeit müssen Holzdecks üblicherweise vor dem Auffeuchten geschützt werden. Herkömmliche Systeme nutzen Bitumen als Abdichtung und Gussasphalt als Schutz‐ und Nutzschicht. Als Alternative wurde ein System auf der Basis von Flüssigkunststoff entwickelt. Die Vorteile sind: eine niedrigere Einbauhöhe, Gewichtsreduzierung, geringere Blasenbildung, schnellere Verarbeitung und die Zugänglichkeit für Inspektionen. Aufgrund der größeren Verformungen von Holzkonstruktionen im Vergleich zu Stahl‐ oder Betonkonstruktionen, bedingt durch die inhärenten Eigenschaften des niedrigeren E‐Moduls des orthotropen und hygroskopischen Materialverhaltens von Holz, kommt es dennoch vermehrt zu Rissbildungen. Ein bereits zugelassenes und verwendetes System für Betondecks, das auf heiß aufgesprühtem Polyurea basiert, wurde als vielversprechende Lösung erkannt. Anhand einer künstlichen Bewitterung wurde der Einfluss der Alterung gesondert am Polymersystem untersucht. Obwohl optisch nur eine begrenzte Veränderung an der Oberfläche der Versiegelung erkennbar ist, zeigen die mechanischen Zugprüfungen, dass es trotzdem zu einer ganzheitlichen Veränderung des Polymers kommt. Zudem können die Zugresultate durch die Prüfkörperhalterung beeinflusst werden, da thermische Ausdehnungen lokale Dehnungen verursachen, die das Polymer stärker schädigen als UV‐Strahlung.
Continuous Titration Based Method for Rapid In‐Solution Analysis of Non‐Covalent Interactions
Authors: Willmer Philipp , Hundahl Adam C. , Marie Rodolphe , Jensen Henrik 
Published: February 2025

AbstractDevelopment of new drugs typically involves the identification and validation of molecular inhibitors or promotors of endogenous biological processes. The identification of ligands that can bind the target of interest is typically achieved by screening large libraries of small molecules, using analytical methods that only provide yes/no answers. These methods are only qualitative and often associated with unacceptable amounts of false positives and negatives. Quantitative methods are in general more accurate but time intensive. This is mainly due to repeating measurements of a dilution series in order to generate a titration curve and measure the dissociation constant (Kd). In this work, we introduce Continuous Titration Based Spectral Related Intensity Change (cSPRING), that combines Taylor dispersion analysis (TDA) with ratiometric fluorescence detection to measure a Kd in a single experiment. cSPRING is an in‐solution method that reduces the sample preparation time 8‐fold and requires only nanograms of protein. We show a good agreement of cSPRING with other quantitative methods for three well‐known protein‐small molecule interactions with binding affinities ranging from the low nanomolar to high micromolar. In addition, we show that cSPRING is able to measure binding affinities in under a minute, highlighting its efficiency and potential for screening applications.
Exploring Bonding in Bioinorganic Chemistry: Ab Initio Valence Bond Calculations of Iron(II)‐CO and Iron(IV)‐Oxo Units in Cytochrome P450 under Oriented External Electric Fields
Authors: Zhang Enhua , Hirao Hajime 
Published: February 2025

AbstractWe performed ab initio valence bond (VB) calculations under oriented external electric fields (OEEFs) to explore the bonding nature of iron(II)‐CO and iron(IV)‐oxo units in cytochrome P450 enzymes (P450s). By utilizing ligand‐free models and analyzing changes in electronic structures under OEEFs, we gained insights into how ligands influence the iron center in realistic environments. Our findings revealed that ligand effects in P450s, exerted by the proximal and equatorial ligands, align with an electric field of approximately −0.125 to −0.100 au along the bond axis (Fz). Additionally, the proximal thiolate ligand alone corresponds to a weaker field, with Fz values around −0.060 to −0.050 au. Negative Fz values enhanced π backdonation while suppressing σ donation in iron(II)‐CO, whereas positive Fz values exhibited the opposite trend. Furthermore, negative Fz values significantly stabilized VB structures with higher oxidation states of Fe in iron(IV)‐oxo. In the absence of OEEFs, the oxidation state of Fe in iron(IV)‐oxo is predominantly Fe(II). However, under negative Fz values, VB structures with Fe(III) character become considerably more stable. These findings underscore the significant influence of external electric fields – and by extension, ligands – on the electronic properties of metal‐containing bioinorganic systems.