bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal integration in sound localization via head rotation
Authors: Macpherson Ewan A. , Kim Janet 
Published: November 2012

Information about a sound source’s location in the front/back dimension is present in the relation between head rotation and the resulting changes in interaural time- or level-difference cues. The use of such dynamic cues for localization requires the auditory system to have access to an accurate representation of the orientation and motion of the head in space. We measured, in active and passive rotation conditions, and as a function of head-rotation angle and velocity, normally hearing human listeners’ ability to localize front and rear sources of a low-frequency (0.5–1 kHz) noise band that was not accurately localizable in the absence of head motion. Targets were presented while the head was in motion at velocities of 50–400°/s (active neck rotation) or 25–100°/s (whole-body passive rotation), and were gated on and off as the head passed through a variable-width spatial window. Accuracy increased as window width was increased, which provided access to larger interaural cue changes, but decreased as head-turn velocity increased, which reduced the duration of the stimuli. For both active and passive rotation, these effects were almost exactly reciprocal, such that performance was related primarily to the duration of the stimulus, with ∼100 ms duration required for 75% correct front/back discrimination regardless of the cue-change magnitude or mode of rotation. The efficacy of the dynamic auditory cues in the passive rotation condition suggests that vestibular input is sufficient to inform the auditory system about head motion.
“Rodnik”: A Source of Inspiration
Authors: Oser Jesco 
Published: November 2012

Abstract
The article discusses the history of Princess Mariia Tenishevaʼs workshops at Talashkino which, in the early 1900s, played a significant role in Russia’s Arts and Crafts movement. Recently discovered photographs of the interior of “Rodnik,” the store in Moscow that marketed Talashkino wares from 1903 to 1906, were the occasion to shed more light on Tenisheva’s attempt to revive popular craft traditions by creating artist-designed and hand manufactured goods for daily use.
Sculpture at the “Last Futurist Exhibition of Paintings ‘0.10’ (Zero-Ten)”
Authors: Lodder Christina 
Published: November 2012

Abstract
This article explores the “Last Futurist Exhibition of Paintings ‘0.10’” (1915) as a key moment when Russian painters began to work seriously in three dimensions, exploring the nature of materials, questioning the relationship between art and reality, and ultimately laying the foundation for the subsequent emergence of the Constructivist movement. The exhibition revealed an important strand in Russian creative thinking and practice concerning sculpture and the nature of artistic materials.
The Challenger: Vadim Sidur and His Art
Authors: Glants Musya 
Published: November 2012

Abstract
This article introduces the art of the Russian sculptor Vadim Abramovich Sidur (1924-86), whose innovative sculptural style contrasted the canons of Socialist Realism. Different periods in Sidur’s work are united by universal themes: love and violence, death and birth, the horror of war and its deadly effects on human life. His sculptural heritage is a symbolic reflection of the troubling reality of people whose existence is blighted by hatred and oppression in different forms and shapes. His work combines an apparent lack of emotion with an inner emotional strength that is highly expressive.
Strategic Monuments: Zurab Tsereteli’s Gift Sculptures to the United States in the Eras of Détente, Perestroika, and Anti-Terrorism, 1979-2006
Authors: Woodburn Stephen M. 
Published: November 2012

Abstract
Best known for transforming the look of Moscow in the 1990s, sculptor and artist Zurab Tsereteli has also donated gift monuments abroad to coincide with diplomatic initiatives of the Soviet Union and Russia. This article examines Tsereteli’s gift monuments to the United States, spanning from the era of détente in the late-1970s to the brief window of anti-terrorist solidarity after 11 September 2001. The monuments are located mostly in or near New York City, although the unfortunate Columbus monument still awaits a permanent home (contrary to rumor, however, it did not return to Moscow as Peter the Great). While the motives and intentions informing the gifts provide the initial footing for the reception of the works, they fade to obscurity as the monuments accrue a legacy within the host community over time.
Militia Training and State Control in Republican Hu’nan
Authors: McCord Edward A. 
Published: November 2012

Abstract
This study of Hunan province during China’s Nanjing decade (1927-1937) shows how militia training could play a key role in the extension of state control both over local militia and through militia into local society. Provincial authorities in Hunan used an argument for the need to increase the efficacy of militia through more rigorous military training to justify an activist intervention in local militia organizations. This training goal then provided a means of extending increased state control over militia as provincial personnel were dispatched to “supervise” local militia training, as local militia leaders were evaluated on the basis of their ability to provide this training, and as training content was expanded to include political indoctrination as well as military skills. Meanwhile the government strengthened ties with local militia officers through extended training programs in the provincial capital or in army units. While many of these efforts focused on standing militia forces and their officers, training programs were also instituted for the mass membership of lower-level “volunteer corps.” More than just political indoctrination, the regimentation instilled by regular training programs also worked to increase the state’s control over the lives of its citizens.
Secondary chronic cluster headache treated by posterior hypothalamic deep brain stimulation: First reported case
Authors: Messina Giuseppe , Rizzi Michele , Cordella Roberto , Caraceni Augusto , Zecca Ernesto , Bussone Gennaro , Franzini Angelo , Leone Massimo 
Published: November 2012

Introduction Deep brain stimulation (DBS) of the posterior hypothalamus (pHyp) has been reported as an effective treatment for primary, drug-refractory and chronic cluster headache (CCH). We here describe the use of such a procedure for the treatment of secondary CCH due to a neoplasm affecting the soft tissues of the right hemiface. Methods A 27-year-old man affected by infiltrating angiomyolipoma of the right hemiface who subsequently developed drug refractory homolateral CCH underwent DBS of the right pHyp region at the Fondazione IRCCS Istituto Nazionale Neurologico Carlo Besta. Results After surgery, the patient presented a significant reduction in frequency of pain bouts. However, because of a subsequent infection, the entire system was removed. After re-implantation of the system, successful outcome was observed at 2 years follow-up. Discussion This brief report shows the feasibility of pHyp DBS in secondary drug-refractory CCH syndromes; future reports are needed in order to confirm our positive result.
SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms
Authors: Montes-Moreno Santiago , Ramos-Medina Rocio , Martínez-López Azahara , Barrionuevo Cornejo Carlos , Parra Cubillos Alejandro , Quintana-Truyenque Shirley , Rodriguez Pinilla Socorro María , Pajares Raquel , Sanchez-Verde Lydia , Martinez-Torrecuadrada Jorge , Roncador Giovanna , Piris Miguel Angel 
Published: November 2012

Abstract
SPIB is an Ets transcription factor that is expressed exclusively in mature B cells, T-cell progenitors, and plasmacytoid dendritic cells. In the present study, we developed a novel mAb against the SPIB protein and characterized its expression in major hematolymphoid neoplasms, including a series of 45 cases of blastic plasmacytoid dendritic cell (BPDC) neoplasms and their potential cutaneous mimics. We found that SPIB is expressed heterogeneously among B- and T-cell lymphoma types. Interestingly, SPIB is expressed in a large proportion of nongerminal center type DLBCLs. In cutaneous neoplasms, SPIB is overexpressed in all BPDC neoplasms, but none of its cutaneous mimics. SPIB remains overexpressed in all cases that lack 1 or 2 of the markers used for BPDC neoplasms (ie, CD4, CD56, TCL1, and CD123). We conclude that SPIB expression can be used as a tool for diagnosing BPDC neoplasms, but it needs to be tested in conjunction with the growing arsenal of markers for human plasmacytoid dendritic cells.
Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis
Authors: Cha Seung-Ick , Ryerson Christopher J , Lee Joyce S , Kukreja Jasleen , Barry Sophia S , Jones Kirk D , Elicker Brett M , Kim Dong Soon , Papa Feroz R , Collard Harold R , Wolters Paul J 
Published: November 2012

AbstractBackgroundStress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our objectives were to determine whether circulating caspase-cleaved cytokeratin-18 (cCK-18) is a marker of AEC apoptosis in IPF, define the relationship of cCK-18 with activation of the UPR, and assess its utility as a diagnostic biomarker.MethodsIPF and normal lung tissues were stained with the antibody (M30) that specifically binds cCK-18. The relationship between markers of the UPR and cCK-18 was determined in AECs exposed in vitro to thapsigargin to induce ER stress. cCK-18 was measured in serum from subjects with IPF, hypersensitivity pneumonitis (HP), nonspecific interstitial pneumonia (NSIP), and control subjects.ResultscCK-18 immunoreactivity was present in AECs of IPF lung, but not in control subjects. Markers of the UPR (phosphorylated IRE-1α and spliced XBP-1) were more highly expressed in IPF type II AECs than in normal type II AECs. Phosphorylated IRE-1α and cCK-18 increased following thapsigargin-induced ER stress. Serum cCK-18 level distinguished IPF from diseased and control subjects. Serum cCK-18 was not associated with disease severity or outcome.ConclusionscCK-18 may be a marker of AEC apoptosis and UPR activation in patients with IPF. Circulating levels of cCK-18 are increased in patients with IPF and cCK-18 may be a useful diagnostic biomarker.
Predictors for health facility delivery in Busia district of Uganda: a cross sectional study
Authors: Anyait Agnes , Mukanga David , Oundo George Bwire , Nuwaha Fred 
Published: November 2012

Abstract

Background
Among the factors contributing to the high maternal morbidity and mortality in Uganda is the high proportion of pregnant women who do not deliver under supervision in health facilities. This study aimed to identify the independent predictors of health facility delivery in Busia a rural district in Uganda with a view of suggesting measures for remedial action.

Methods
In a cross sectional survey, 500 women who had a delivery in the past two years (from November 16 2005 to November 15 2007) were interviewed regarding place of delivery, demographic characteristics, reproductive history, attendance for antenatal care, accessibility of health services, preferred delivery positions, preference for disposal of placenta and mother’s autonomy in decision making. In addition the household socio economic status was assessed. The independent predictors of health facility delivery were identified by comparing women who delivered in health facilities to those who did not, using bivariate and binary logistic regression analysis.

Results
Eight independent predictors that favoured delivery in a health facility include: being of high socio-economic status (adjusted odds ratio [AOR] 2.8 95% Confidence interval [95% CI]1.2–6.3), previous difficult delivery (AOR 4.2, 95% CI 3.0–8.0), parity less than four (AOR 2.9, 95% CI 1.6–5.6), preference of supine position for second stage of labour (AOR 5.9, 95% CI 3.5–11.1) preferring health workers to dispose the placenta (AOR 12.1, 95% CI 4.3–34.1), not having difficulty with transport (AOR 2.0, 95% CI 1.2–3.5), being autonomous in decision to attend antenatal care (AOR 1.9, 95% CI 1.1–3.4) and depending on other people (e.g. spouse) in making a decision of where to deliver from (AOR 2.4, 95% CI 1.4–4.6). A model with these 8 variables had an overall correct classification of 81.4% (chi square = 230.3, P < 0.001).

Conclusions
These data suggest that in order to increase health facility deliveries there is need for reaching women of low social economic status and of higher parity with suitable interventions aimed at reducing barriers that make women less likely to deliver in health units such as ensuring availability of transport and involving spouses in the birth plan.
Tumorigenic potential of pituitary tumor transforming gene (PTTG) in vivoinvestigated using a transgenic mouse model, and effects of cross breeding with p53 (+/−) transgenic mice
Authors: Fong Miranda Y , Farghaly Hanan , Kakar Sham S 
Published: November 2012

Abstract

Background
Pituitary tumor-transforming gene (PTTG) is an oncogene that is overexpressed in variety of tumors and exhibits characteristics of a transforming gene. Previous transgenic mouse models to access the tumorigenic potential in the pituitary and ovary have resulted in dysplasia without formation of visible tumors, possibly due to the insufficient expression of PTTG. PTTG expression level is critical for ovarian tumorigenesis in a xenograft model. Therefore, the tumorigenic function of PTTG in vivo remains unclear. We generated a transgenic mouse that overexpresses PTTG driven by the CMV promoter to determine whether PTTG functions as a transforming oncogene that is capable of initiating tumorigenesis.

Methods
Transgenic animals were generated by microinjection of PTTG transgene into the male pronucleus of FVB 0.5 day old embryos. Expression levels of PTTG in tissues of transgenic animals were analyzed using an immunohistochemical analysis. H&E staining and immunohistostaining were performed to examine the type of tumor in transgenic and PTTG transgenic/p53+/- animals.

Results
PTTG transgenic offspring (TgPTTG) were monitored for tumor development at various ages. H&E analysis was performed to identify the presence of cancer and hyperplastic conditions verified with the proliferation marker PCNA and the microvessel marker CD31. Immunohistochemistry was performed to determine transgene expression, revealing localization to the epithelium of the fallopian tube, with more generalized expression in the liver, lung, kidney, and spleen. At eight months of age, 2 out of 15 TgPTTG developed ovarian cancer, 2 out of 15 developed benign tumors, 2 out of 15 developed cervical dysplasia, and 3 out of 15 developed adenomyosis of the uterus. At ten months of age, 2 out of 10 TgPTTG developed adenocarcinoma of the ovary, 1 out of 10 developed a papillary serous adenocarcinoma, and 2 out of 10 presented with atypia of ovarian epithelial cells. Tumorigenesis is a multi-step process, often requiring multiple oncogenes and/or inactivation of tumor suppressor genes. Therefore, to understand the contribution of p53 to PTTG induced tumorigenesis, we crossbred TgPTTG to p53+/− mice and maintained those 8 to 10 months. TgPTTG/p53+/− animals developed sarcomas faster than p53+/− alone as well as different tumor types in addition to cervical carcinomas in situ in 10 out of 17 females.

Conclusions
We conclude that while PTTG is a functional transforming oncogene, it requires an additional partner to effectively promote tumorigenesis through the loss of p53 include or between function or modulation.
Let-7 miRNA-binding site polymorphism in the KRAS 3′UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/− cetuximab
Authors: Kjersem Janne B , Ikdahl Tone , Guren Tormod , Skovlund Eva , Sorbye Halfdan , Hamfjord Julian , Pfeiffer Per , Glimelius Bengt , Kersten Christian , Solvang Hiroko , Tveit Kjell M , Kure Elin H 
Published: November 2012

Abstract

Background
Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site (LCS6) within the 3′untranslated region (3′UTR) of KRAS (rs61764370) and clinical outcome in metastatic colorectal cancer (mCRC) patients receiving cetuximab. The variant allele has also been associated with increased cancer risk. We aimed to reveal the incidence of the variant allele in a colorectal cancer screening population and to investigate the clinical relevance of the variant allele in mCRC patients treated with 1st line Nordic FLOX (bolus 5-fluorouracil/folinic acid and oxaliplatin) +/− cetuximab.

Methods
The feasibility of the variant allele as a risk factor for CRC was investigated by comparing the LCS6 gene frequencies in 197 CRC patients, 1060 individuals with colorectal polyps, and 358 healthy controls. The relationship between clinical outcome and LCS6 genotype was analyzed in 180 mCRC patients receiving Nordic FLOX and 355 patients receiving Nordic FLOX + cetuximab in the NORDIC-VII trial (NCT00145314).

Results
LCS6 frequencies did not vary between CRC patients (23%), individuals with polyps (20%), and healthy controls (20%) (P = 0.50). No statistically significant differences were demonstrated in the NORDIC-VII cohort even if numerically increased progression-free survival (PFS) and overall survival (OS) were found in patients with the LCS6 variant allele (8.5 (95% CI: 7.3-9.7 months) versus 7.8 months (95% CI: 7.4-8.3 months), P = 0.16 and 23.5 (95% CI: 21.6-25.4 months) versus 19.5 months (95% CI: 17.8-21.2 months), P = 0.31, respectively). Addition of cetuximab seemed to improve response rate more in variant carriers than in wild-type carriers (from 35% to 57% versus 44% to 47%), however the difference was not statistically significant (interaction P = 0.16).

Conclusions
The LCS6 variant allele does not seem to be a risk factor for development of colorectal polyps or CRC. No statistically significant effect of the LCS6 variant allele on response rate, PFS or OS was found in mCRC patients treated with 1st line Nordic FLOX +/− cetuximab.
Current iodine nutrition status and progress toward elimination of iodine deficiency disorders in Jazan, Saudi Arabia
Authors: Alsanosy Rashad Mohammed Ali , Gaffar Abdelrahim Mutwakel , Khalafalla Husam Eldin Elsawi , Mahfouz Mohamed Salih , Zaid Abdel Naser Shaaban , Bani Ibrahim Ahmed 
Published: November 2012

AbstractBackgroundThe term iodine deficiency disorders (IDD) refers to all the effects of iodine deficiency on growth and development in human and animal populations that can be prevented by correction of the iodine deficiency. The objective of this paper was to determine the iodine nutrition status among schoolchildren in the Jazan Region of the Kingdom of Saudi Arabia (KSA), by measuring urinary iodine concentrations and by clinical assessments of goiter rate.MethodsA school-based cross-sectional survey was conducted in the Jazan region of southwestern KSA from May to November 2010. A total of 311 children, aged 6–13 years, drawn from 12 schools, were selected by a three-stage cluster random sampling method. Data on sociodemographic characteristics were collected using a structured questionnaire. Urine samples were collected and physical examinations were conducted to determine the presence or absence of goiter. Data were analyzed using SPSS version 17.0. Chi square and independentt-tests were used for proportions and mean comparisons between groups.ResultsOut of 360 selected children, 311 were examined. There were 131 males (42%) and 180 females (58%). The median urinary iodine concentration (UIC) of the study group was 421 μg/L. The study population proportion with UIC > 300 μg/L was 74% with a higher proportion among males and urban populations. The proportion of children with UIC of 100–300 μg/L was only 21% and was significantly higher among females compared with males (p< 0.001). Only about 3% of the children had a median UIC less than 50 μg/L. The prevalence of total goiter rate (TGR) among the sample of schoolchildren in Jazan was 11%, with significant variations between rural and urban populations and by gender.ConclusionsThe present study demonstrates a remarkable achievement in Universal Salt Iodization (USI) and IDD elimination goals in the Jazan area. However, UIC levels reflect excessive iodine intake and may put the population at risk of adverse health consequences like iodine-induced hyperthyroidism and autoimmune thyroid diseases.
Respiratory symptoms and illnesses among brick kiln workers: a cross sectional study from rural districts of Pakistan
Authors: Shaikh Shiraz , Nafees Asaad Ahmed , Khetpal Vikash , Jamali Abid Ali , Arain Abdul Manan , Yousuf Akram 
Published: November 2012

Abstract

Background
Occupational risk factors are one of the major causes of respiratory illnesses and symptoms, and account for 13% of chronic obstructive pulmonary disease and 11% of asthma worldwide. Majority of brick kilns in Pakistan use wood and coal for baking the bricks which makes the brick kiln workers susceptible to high exposure of air pollution. This study was designed to describe frequency of chronic respiratory symptoms and illnesses and study the association between these symptoms and different types of work.

Methods
This was a questionnaire based cross sectional survey conducted among the brick kiln workers in Larkana and Dadu districts, Sindh, Pakistan. A total of 340 adult men were assessed using translated version of the American Thoracic Society Division of Lung Disease (ATS-DLD) questionnaire. Logistic regression analysis was done to determine the relationship between various socio-demographic and occupational factors (age, education, type of work, number of years at work, smoking status), and the respiratory symptoms and illnesses (chronic cough, chronic phlegm, wheeze, Chronic Bronchitis and asthma).

Results
Results of the study show that 22.4% workers had chronic cough while 21.2% reported chronic phlegm. 13.8% had two or more attacks of shortness of breath with wheezing. 17.1% workers were suffering from Chronic Bronchitis while 8.2% reported physician diagnosed asthma. Amongst the non-smoking workers 8.9% had Chronic Bronchitis. Multivariate analysis found that workers involved in brick baking were more likely to have Chronic Bronchitis (OR= 3.7, 95% CI 1.1-11.6, p=<0.05) and asthma (OR= 3.9, 95% CI 1.01-15.5, p=<0.05) compared to those involved in carriage and placement work.

Conclusion
A high frequency of respiratory symptoms and illnesses was observed among brick kiln workers. Age, nature of work and smoking were strong predictors of developing these symptoms and illnesses.