bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipolysis pathways modulate lipid mediator release and endocannabinoid system signaling in dairy cows’ adipocytes
Authors: Myers Madison N. , Chirivi Miguel , Gandy Jeff C. , Tam Joseph , Zachut Maya , Contreras G. Andres 
Published: August 2024

Abstract
Background
As cows transition from pregnancy to lactation, free fatty acids (FFA) are mobilized from adipose tissues (AT) through lipolysis to counter energy deficits. In clinically healthy cows, lipolysis intensity is reduced throughout lactation; however, if FFA release exceeds tissue demands or the liver’s metabolic capacity, lipid byproducts accumulate, increasing cows’ risk of metabolic and infectious disease. Endocannabinoids (eCBs) and their congeners, N-acylethanolamines (NAEs), are lipid-based compounds that modulate metabolism and inflammation. Their synthesis and release depend upon the availability of FFA precursors and the abundance of synthesizing and degrading enzymes and transporters. Therefore, we hypothesized that eCB production and transcription of endocannabinoid system components are modulated by lipolysis pathways in adipocytes. To test this hypothesis, we stimulated canonical (isoproterenol, 1 µmol/L; ISO) and inflammatory (lipopolysaccharide, 1 µg/mL; LPS) lipolysis pathways in adipocytes isolated from the AT of 5 Holstein dairy cows. Following, we assessed lipolysis intensity, adipocytes’ release of eCBs, and transcription of endocannabinoid system components.

Results
We found that ISO and LPS stimulated lipolysis at comparable intensities. Exposure to either treatment tended to elevate the release of eCBs and NAEs by cultured adipocytes; however, specific eCBs and NAEs and the transcriptional profiles differed by treatment. On one hand, ISO enhanced adipocytes’ release of 2-arachidonoylglycerol (2-AG) but reduced NAE production. Notably, ISO enhanced the cells’ expression of enzymes associated with 2-AG biosynthesis (INPP5F, GDPD5, GPAT4), transport (CD36), and adipogenesis (PPARG). Conversely, LPS enhanced adipocytes’ synthesis and release of N-arachidonoylethanolamide (AEA). This change coincided with enhanced transcription of the NAE-biosynthesizing enzyme, PTPN22, and adipocytes’ transcription of genes related to eCB degradation (PTGS2, MGLL, CYP27B1). Furthermore, LPS enhanced adipocytes’ transcription of eCB and NAE transporters (HSPA1A, SCP2) and the expression of the anti-adipogenic ion channel, TRPV3.

Conclusions
Our data provide evidence for distinct modulatory roles of canonical and inflammatory lipolysis pathways over eCB release and transcriptional regulation of biosynthesis, degradation, transport, and ECS signaling in cows’ adipocytes. Based on our findings, we conclude that, within adipocytes, eCB production and ECS component expression are, at least in part, mediated by lipolysis in a pathway-dependent manner. These findings contribute to a deeper understanding of the molecular mechanisms underlying metabolic regulation in dairy cows’ AT, with potential implications for prevention and treatment of inflammatory and metabolic disorders.

Graphical Abstract
Fitcam: detecting and counting repetitive exercises with deep learning
Authors: Japhne Ferdinandz , Janada Kevin , Theodorus Agustinus , Chowanda Andry 
Published: August 2024

AbstractPhysical fitness is one of the most important traits a person could have for health longevity. Conducting regular exercise is fundamental to maintaining physical fitness, but with the caveat of occurring injury if not done properly. Several algorithms exists to automatically monitor and evaluate exercise using the user’s pose. However, it is not an easy task to accurately monitor and evaluate exercise poses automatically. Moreover, there are limited number of datasets exists in this area. In our work, we attempt to construct a neural network model that could be used to evaluate exercise poses based on key points extracted from exercise video frames. First, we collected several images consists of different exercise poses. We utilize the the OpenPose library to extract key points from exercise video datasets and LSTM neural network to learn exercise patterns. The result of our experiment has shown that the methods used are quite effective for exercise types of push-up, sit-up, squat, and plank. The neural-network model achieved more than 90% accuracy for the four exercise types.
TVRAVNF: an efficient low-cost TEE-based virtual remote attestation scheme for virtual network functions
Authors: Yuan Jie , Xu Rui , Wei Xinghai , Miao Keji , Liu Dongxiao 
Published: August 2024

AbstractWith the continuous advancement of virtualization technology and the widespread adoption of 5G networks, the application of the Network Function Virtualization (NFV) architecture has become increasingly popular and prevalent. While the NFV architecture brings a lot of advantages, it also introduces security challenges, including the effective and efficient verification of the integrity of deployed Virtual Network Functions (VNFs) and ensuring the secure operation of VNFs. To address the challenge of efficiently conducting virtual remote attestation for VNFs and establishing trust in virtualized environments like NFV architecture, we propose TVRAVNF, which is a highly efficient and low-cost TEE-based virtual remote attestation scheme for VNFs. The scheme we proposed ensures the security and effectiveness of the virtual remote attestation process by leveraging TEE. Furthermore, we introduces a novel local attestation mechanism, which not only reduces the overall overhead of the virtual remote attestation process but also shortens the attestation interval to mitigate Time-Of-Check-Time-Of-Use attacks, thereby enhancing overall security. We conduct experiments to validate the overhead of the TVRAVNF scheme and compare its performance with that of a typical remote attestation process within a maximum unattested time interval. The experimental results demonstrate that, by employing the local attestation mechanism, our solution achieves nearly an 80% significant performance improvement with a relatively small time overhead for small to medium-sized files. This further substantiates the significant advantages of our approach in both security and efficiency.
Potential antidiabetic activity of probiotic and Garcinia kola-yoghurt and its role in regulation of male fertility-stimulating hormones in high-fat diet/low dose streptozotocin-treated rats
Authors: Mohamed Rasha S. , Fouda Karem , Zaghloul Ahmed H. , Abdel-Salam Ahmed M. 
Published: August 2024

AbstractGarcinia kola Heckel seed is widely used in the African traditional medicine as a aphrodisiac and male fertility enhancer. Probiotics can reestablish glucose homeostasis and improve blood lipid profiles by altering the composition of the intestinal flora. The study was planned to assess the efficacy of co-administration of Garcinia kola seed aqueous infusion and probiotic yoghurt in the management of diabetes and associated male fertility-stimulating hormones abnormalities. G. kola seed infusion was prepared, assessed for radical scavenging capacity, total phenolic content and phenolic profile using HPLC. Fermented yoghurt was prepared and inoculated with probiotic mixture. Rats were given a high-fat diet for four weeks and received an intraperitoneal injection of streptozotocin (30 mg/kg) to induce type 2 diabetes. Diabetic rats were received 200 mg/kg freeze-dried infusion of G. kola seed, probiotics yoghurt, and probiotic yoghurt mixed with G. kola once a day for four weeks. The levels of glucose, insulin, testosterone, follicle-stimulating hormone, luteinizing hormone, inflammatory indicators, oxidative markers, lipid profiles and liver as well as kidney biochemical indicators were measured. The administration of G. kola seed, probiotic yoghurt, or their combination to diabetic rats demonstrated potential anti-diabetic effects as evidenced by the down-regulation in glucose, insulin, lipid profile, oxidative markers, and inflammatory markers simultaneously with an up-regulation in testosterone, FSH, and LH levels compared to diabetic rats. G. kola seed, probiotic yoghurt, or their combination increased testosterone, FSH, and LH levels and are thought to have therapeutic promise for T2DM and its related oxidative stress.
Graphical Abstract
Global and regional cardiac magnetic resonance feature tracking left ventricular strain analysis in assessing early myocardial disease in β thalassemia major patients
Authors: Batouty Nihal M. , Tawfik Ahmad M. , Sobh Donia M. , Gadelhak Basma N. , El-Ashwah Shimaa , Hussein Mohamed Abdelghafar , Gad Mai , Aziz A. Ashraf Abd El , El-Shahed Mahmoud Abd , Karam Rasha 
Published: August 2024

Abstract
Background
Cardiac magnetic resonance imaging (CMR) is the modality of choice for quantification of myocardial iron overload in β-thalassemia major patients using the T2* sequence. CMR feature tracking (FT) is a recent magnetic resonance imaging tool that gives an idea about myocardial fibers deformation; thus, it can detect early impairment in myocardial function even before the reduction in ejection fraction.

Methods
This study aims to assess the ability of left ventricular CMR-FT in the early detection of systolic dysfunction in β thalassemia major patients and to correlate it with the degree of myocardial iron overload measured by CMR T2*. This prospective study enrolled 57 β thalassemia major patients who received long-term blood transfusion and 20 healthy controls. CMR was used to evaluate left ventricular volumes, ejection fraction, and the amount of myocardial T2*. A two-dimensional left ventricular FT analysis was performed. Both global and segmental left ventricular strain values were obtained.

Results
The mean global circumferential strain (GCS) and global radial strain (GRS) values were significantly lower in patients compared to control (P = 0.002 and P = 0.006, respectively). No correlation was found between T2* values and ejection fraction; however, there was a significant correlation between T2* values and GCS and GRS (P = 0.012 and P = 0.025, respectively) in thalassemia patients. Regional strain revealed significantly lower values of GCS and GRS in basal regions compared to apical ones (P = 0.000).

Conclusions
Our study revealed that CMR-FT can play a role in the early detection of systolic impairment in thalassemia patients.
International teacher survey on green and sustainable chemistry (GSC) practical activities: design and implementation
Authors: Delaney Seamus , Chiavaroli Lisa , Dissanayake Tharani , Pham Lam , Schultz Madeleine 
Published: August 2024

Abstract
High school chemistry teachers typically share a passion to engage students with hands-on practical experiences. However, teachers worldwide face similar challenges of lack of time and resources for laboratory activities. National standards and traditions can also constrain and dictate the level and content of school chemistry practical experiences. In recent years, some national curricula have included a growing focus on the relevance of chemistry to sustainability and environmental issues. Until now, little has been known about what practical activities teachers actually do with their students, and whether practical activities concerning green and sustainable chemistry are being implemented in schools. In this project, we aimed to determine a baseline of teacher perspectives – how often they run practical activities with their students, what factors are important when choosing a practical activity, what barriers they face in running practical activities, and whether their activities relate to sustainability. This was approached through a major international survey of in-service high school chemistry teachers conducted in over 35 local languages in over 60 countries. Here, we present the initial stages of the project: design of the survey, recruitment of country coordinators, translation, and the implementation process.
Comparing the quality of life of adolescent girls with and without polycystic ovary syndrome and identifying the predictor factors
Authors: Homaei Ali , Razzaghi Alireza , Dodangeh Samira , Kaveh Azin , Daneshi Salman , Hushmandi Kiavash , Saffari Fatemeh 
Published: August 2024

Abstract

Objectives
Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that affects the endocrine glands and reproductive processes in adolescent girls, potentially impacting their quality of life. This study aims to compare the quality of life between adolescent girls with PCOS and those without PCOS.

Methods
The present study is an analytical cross-sectional study. It involved 12–18-year-old girls who were diagnosed with PCOS based on the Rotterdam criteria for the case group. An ordinal logistic regression model was employed to assess the impact of the studied variables on different levels of quality of life, and Odds Ratio (OR) values were determined for predictor variables.

Results
The findings of the study revealed that the control group had a significantly higher percentage of individuals with excellent quality of life (score 209–260) compared to the group with polycystic ovary syndrome (p<0.05). The results of the ordinal logistic regression analysis indicated that age variables (OR=0.64, CI 95 %; 0.44–0.93), menstrual disorders (OR=0.07, CI 95 %; 0.01–0.38), and micromastia (OR=0.03, CI 95 %; 0.004–0.34) were identified as factors influencing the quality of life of girls with polycystic ovary syndrome.

Conclusions
It was concluded that patients with PCOS had a lower quality of life score. The variables of age, menstrual disorders, and micromastia were determined as influencing factors the quality of life. The results of this study are significant and warrant further research in this area, particularly with regard to the financial resources of patients in the challenging economic circumstances facing the nation – the majority of which are brought on by economic sanctions.
Curious ill-posedness phenomena in the composition of non-compact linear operators in Hilbert spaces
Authors: Kindermann Stefan , Hofmann Bernd 
Published: August 2024

Abstract
We consider the composition of
operators with non-closed range in
Hilbert spaces and how the nature of
ill-posedness is affected by their composition. Specifically, we study the
Hausdorff-, Cesàro-, integration
operator, and their adjoints, as well as some combinations of those. For the composition
of the Hausdorff- and the
Cesàro-operator,
we give
estimates of the decay of the corresponding singular values.
As a curiosity, this provides also
an example of two practically relevant
non-compact operators, for which
their composition is compact.
Furthermore, we characterize those operators for which a composition with
a non-compact operator gives a compact one.
BDNF-altering cell death mechanisms of brain disorders: pyroptosis and/or ferroptosis? A systematic review
Authors: Ahmad Abdullah Amirul Hafiz , Jufri Nurul Farhana , Masre Siti Fathiah , Rajab Nor Fadilah , Damanhuri Hanafi Ahmad , Che Roos Nur Aishah , Ibrahim Farah Wahida 
Published: August 2024

Abstract
The brain plays a central role in controlling and regulating bodily activities. Given its significance, the brain needs to remain in optimal condition to function properly. Neurodegenerative diseases arise when the mechanisms maintaining brain homeostasis fail, resulting in prolonged and uncontrolled activation of cell death pathways. Increasingly, researchers are focusing on specific types of cell death, such as ferroptosis and pyroptosis, due to their potential as targets for preventing and treating neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) is a crucial growth factor for neurogenesis, neuronal survival, and maintenance, and is thus implicated in cell death mechanisms. This review aims to elucidate the role of BDNF in the ferroptosis and pyroptosis mechanisms that impact brain health. To achieve this, three databases – PubMed, Scopus, and Web of Science – were searched for relevant studies, yielding 95 articles, of which only 14 were aligned with the study’s aim. Ferroptosis (iron-dependent cell death) and pyroptosis (inflammatory cell death) are distinct modes of cell death; however, this review found both mechanisms are associated with oxidative stress. Consequently, the findings suggest that ferroptosis and pyroptosis collectively impact brain health conditions such as depression, cognitive deficiencies, and anxiety, which are notably linked to reduced BDNF levels.
Entre a Pedagogia da Rua e a Sociedade Capsular
Authors: Assumpção Rodrigo Vitorino , Busnardo Filho Antonio 
Published: August 2024

O presente trabalho tem como tema as ruas da cidade pós-moderna, que emerge com um papel estruturante no contexto urbano contemporâneo. A rua estabelece planos de vivências em diferentes momentos da vida social. O homem marca seu espaço e seu tempo nas ruas da cidade. Isso significa que cada sociedade abordará diferentemente as questões sobre a rua, pois em cada período da História, o homem deixa seus registros no tempo e no espaço. Nesse contexto, a rua tem um papel ambíguo, é vista ora como palco e cenário, ora como plateia das manifestações sócio culturais dos seus habitantes. Desta forma, a cidade pode ser interpretada como um sistema simbólico onde a identidade urbana e sua respectiva arquitetura (como produtos da cultura humana) são reflexos de sociedades que habitaram - ou habitam - esse espaço. A rua coloca-se em um papel fundamental para pensar a cidade, pois é nela que o homem deixa sua marca no tempo e no espaço. Na cidade contemporânea, as ruas são palco de uma sociedade capsular, isto é, habitantes com comportamentos endógenos, individualizados. Isso acarreta uma sociedade do medo, da indiferença, da pedagogia do desapego. Mas é na rua que emerge uma pedagogia urbana – essência da Polis Grega – pouco discutida contemporaneamente. Nesse contexto, caminhar pela cidade constitui uma ação fundamental para refletir sobre a pedagogia urbana. O presente trabalho apresenta uma relação antagônica entre a sociedade capsular e a pedagogia urbana, a fim de compreender como as relações sociais se estabelecem nas ruas da cidade contemporânea.
IDENTIFIKASI SUARA JANTUNG BERBASIS KOMPUTER
Authors: Listyalina Latifah 
Published: August 2024

Penelitian tentang klasifikasi suara jantung manusia berbasis komputer dimotivasi oleh kebutuhan akan alat bantu yang lebih efisien bagi dokter dalam proses klasifikasi suara jantung daripada stetoskop konvensional. Alat ini memanfaatkan proses komputasi untuk memungkinkan penilaian yang lebih mudah, cepat, dan akurat terhadap suara jantung. Dengan menggunakan pendekatan komputasi, alat ini dapat membantu dokter dalam mendiagnosis kondisi jantung dengan lebih baik. Klasifikasi suara jantung manusia berbasis komputer diciptakan sebagai solusi dalam dunia medis, bertujuan untuk membantu dokter dalam menganalisis suara jantung dan menghasilkan diagnosis yang lebih tepat. Melalui penggunaan metode fractal, alat ini mampu mengolah data suara jantung dengan efisien. Software Klasifikasi Suara Jantung Manusia Berbasis ini telah terbukti mampu mengklasifikasikan sampel suara jantung menggunakan metode KNN (K_Nearest Neighbour) dengan baik, meningkatkan kinerja diagnosis yang diberikan oleh dokter.
RANCANG BANGUN SISTEM INFORMASI DI BALAI LATIHAN KERJA KOTA PALOPO
Authors: Mukramin Mukramin , Fitrah A'Afiaat , Muhallim Muhlis 
Published: August 2024

Perkembangan teknologi yang pesat di berbagai bidang, termasuk pendidikan, pemerintahan, sosial, budaya, dan bisnis, telah menghasilkan perangkat elektronik seperti komputer yang mampu mengolah dan menyimpan data secara cepat dan akurat. Menghadapi situasi ini, diperlukan sistem terkomputerisasi untuk mengolah data dan informasi pelatihan yang sebelumnya dilakukan secara manual di BLK Kota Palopo. Penelitian dengan judul "Perancangan Aplikasi di Balai Latihan Kerja Kota Palopo" bertujuan untuk mengatasi masalah ini. Data dikumpulkan melalui wawancara dengan pihak terkait dan kuesioner yang disebarkan kepada 10 calon dan alumni pelatihan aktif. Perancangan aplikasi menggunakan Metode Waterfall, yang terdiri dari tahap-tahap berurutan seperti requirement, design, implementation, verification, dan maintenance. Setelah mengumpulkan dan menghitung kuesioner, total skor yang diperoleh adalah 148 dari maksimal 160, menghasilkan persentase 92,5%. Berdasarkan tabel Kriteria Interpretasi Skor, hasil ini termasuk kategori "sangat baik" (81-100%). Penelitian ini menunjukkan bahwa pendekatan sistematis dalam pengembangan aplikasi dapat menghasilkan sistem yang efektif dan sesuai kebutuhan pengguna, meningkatkan efisiensi dan akurasi pengolahan data pelatihan di BLK Kota Palopo. Keywords:Sistem Informasi, BLK Kota Palopo, Waterfall,Website.
PERANCANGAN ANTARMUKA APLIKASI PENYEWAAN GEDUNG PERTEMUAN “TITIK TEMU” MENGGUNAKAN METODE DESIGN THINKING
Authors: Badriyyah Shofiyyatul , Kartika Dhian Satria Yudha , Najaf Abdul Rezha Efrat 
Published: August 2024

Gedung pertemuan adalah suatu bangunan yang dibangun khusus yang digunakan untuk menjadi tempat diselanggarakannya berbagai jenis acara yang memungkinkan melibatkan orang banyak. Aktivitas penyewaan gedung pertemuan banyak memberikan manfaat kepada penyewa karena selain menyediakan tempat yang memadai, biasanya didukung dengan fasilitas yang disediakan oleh pengelola gedung. Namun sayangnya proses penyewaan masih tergolong rumit karena terdapat beberapa kendala dan belum efisien. Maka dari itu, penelitian ini bertujuan untuk melakukan perancangan desain antarmuka aplikasi penyewaan gedung pertemuan yang memiliki nilai kegunaan yang baik. Penelitian ini membahas desain antarmuka aplikasi penyewaan gedung pertemuan berbasis mobile menggunakan metode Design Thinking, yang berfokus pada pemahaman pengguna dan redefinisi masalah untuk menemukan strategi dan solusi inovatif. Desain diuji dengan dua jenis pengujian yaitu usability testing melalui platform Maze.co yang mendapatkan nilai kegunaan 84 untuk penyewa dan 86 untuk pengelola, serta system usability scale (SUS) yang mendapatkan nilai 85 (good dan acceptable).
PENGEMBANGAN BACKEND MENGGUNAKAN METODE EXTREME PROGRAMMING (XP) PADA APLIKASI RESERVASI PESONA JAVA IJEN HOMESTAY
Authors: Viani Devi Okta , No Subo , Prasetyo Junaedi Adi 
Published: August 2024

Pesona Java Ijen merupakan sebuah homestay yang beroperasi di Desa Tamansari Licin Banyuwangi. Homestay adalah jenis akomodasi yang ideal untuk dikembangkan di desa wisata karena selain memiliki harga yang terjangkau, juga dapat meningkatkan pendapatan. Berdasarkan survey di lapangan, sistem informasi reservasi kamar di Pesona Java Ijen ini reservasinya masih manual atau masih menggunakan via whatsapp dan tidak ada fitur untuk reservasinya juga fitur-fitur lainnya dan tampilan sistem informasinya itu masih kurang menarik untuk para wisatawan hanya terdapat gambar homestay nya saja. Masalah ini dapat diselesaikan dengan mengembangkan sistem informasi reservasi yang memusatkan semua data reservasi dan mempercepat serta mempermudah proses reservasi. Sistem ini dikembangkan menggunakan Framework Laravel dengan metode Extreme Programming (XP) dalam model Agile untuk menyelesaikan masalah tersebut. Metode ini diterapkan untuk menganalisis kebutuhan pengguna, mengestimasi waktu pengembangan sistem, merancang penyimpanan data dan antarmuka sistem, membangun sistem, serta menyerahkannya. Sistem informasi reservasi homestay ini dikembangkan berbasis website. Dengan adanya website ini, pemesan dapat melakukan reservasi tanpa harus terlebih dahulu menanyakan ketersediaan kamar kepada pihak Pesona Java Ijen, sekaligus memudahkan Pesona Java Ijen dalam pendataan reservasi.Kata kunci : Pengembangan, Reservasi Homestay, Framework Laravel, Extreme Programming.