bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Identification of Sorting Receptors Involved in Trafficking of Soluble Lytic Vacuolar Proteins in Vegetative Cells of Arabidopsis
Authors: Lee Yongjik , Jang Mihue , Song Kyungyoung , Kang Hyangju , Lee Myoung Hui , Lee Dong Wook , Zouhar Jan , Rojo Enrique , Sohn Eun Ju , Hwang Inhwan 
Published: November 2012

Abstract
In eukaryotic cells, protein trafficking plays an essential role in biogenesis of proteins that belong to the endomembrane compartments. In this process, an important step is the sorting of organellar proteins depending on their final destinations. For vacuolar proteins, vacuolar sorting receptors (VSRs) and receptor homology-transmembrane-RING H2 domain proteins (RMRs) are thought to be responsible. Arabidopsis (Arabidopsis thaliana) contains seven VSRs. Among them, VSR1, VSR3, and VSR4 are involved in sorting storage proteins targeted to the protein storage vacuole (PSV) in seeds. However, the identity of VSRs for soluble proteins of the lytic vacuole in vegetative cells remains controversial. Here, we provide evidence that VSR1, VSR3, and VSR4 are involved in sorting soluble lytic vacuolar and PSV proteins in vegetative cells. In protoplasts from leaf tissues of vsr1vsr3 and vsr1vsr4 but not vsr5vsr6, and rmr1rmr2 and rmr3rmr4 double mutants, soluble lytic vacuolar (Arabidopsis aleurain-like protein:green fluorescent protein [GFP] and carboxypeptidase Y:GFP and PSV (phaseolin) proteins, but not the vacuolar membrane protein Arabidopsis βFructosidase4:GFP, exhibited defects in their trafficking; they accumulated to the endoplasmic reticulum with an increased secretion into medium. The trafficking defects in vsr1vsr4 protoplasts were rescued by VSR1 or VSR4 but not VSR5 or AtRMR1. Furthermore, of the luminal domain swapping mutants between VSR1 and VSR5, the mutant with the luminal domain of VSR1, but not that of VSR5, rescued the trafficking defects of Arabidopsis aleurain-like protein:GFP and phaseolin in vsr1vsr4 protoplasts. Based on these results, we propose that VSR1, VSR3, and VSR4, but not other VSRs, are involved in sorting soluble lytic vacuolar and PSV proteins for their trafficking to the vacuoles in vegetative cells.
Dignity in care survey in North Wales
Authors: Morgan Gareth 
Published: November 2012

PurposeThis paper aims to report on a survey conducted within North Wales regarding the perceptions of older people on dignity in care issues in the services received.Design/methodology/approachThe North Wales Dignity in Care Forum did a survey, driven by the question: What one change today could make a difference to you tomorrow? National Health Service and local authority organisations participated in the survey. In total, 499 responses were received.FindingsSome key themes were identified, particularly relating to keeping independence, individual respect and personal care. National Health Service and local authority responses had some differences.Research limitations/implicationsLimitations include an absence of demographic data, an open sampling frame, so a response rate was difficult to measure and an inability to validate or further explore issues raised. This survey shows the value of a rapid and simple method of collecting information from older people accessing services.Originality/valueThe findings of the North Wales survey may help in taking forward new models of working for older people, especially for the most vulnerable.
Rethinking a framework for dementia 2: a new model of care
Authors: Minghella Edana , Schneider Kate 
Published: November 2012

PurposeThis is the second of two papers that aim to propose a revised model of care for dementia based on the combined findings of a number of projects undertaken by the authors.Design/methodology/approachThe paper is a conceptual discussion based on the findings from a series of projects in which the key methodologies included listening to people with dementia and carers, non‐participant observation of services, and reviews of good practice, policy and literature.FindingsThe paper challenges traditional approaches to dementia services, and offers a radical new approach, based on a five‐pronged model of care: guiding principles, the condition itself, the person with the condition, services and effectiveness.Practical implicationsThis paper challenges commissioners and service planners to make a radical shift in their approach to dementia, people living with it and services and opportunities that should be in place. It proposes that dementia services should be delivered principally in the community, led by primary care, with opportunities for inclusion and social engagement. Specialist dementia services need to refocus on providing effective interventions, training, advice and support. People living with dementia have assets as well as needs; this means changing practice to work alongside people as partners in care, nurture their capacity and capabilities and recognise and pre‐empt increasing needs.Originality/valueThe revised model of care implies a radically different approach to commissioning, designing and delivering services. It is a challenging, but optimistic, model, in which high quality, focused, cost‐effective services and community developments could work together as a whole system, to make living well with dementia a real possibility.
Time banking – new social currency or waste of time?
Authors: Lashko Gary 
Published: November 2012

PurposeThe aims of this article are to introduce and explore the concept of time banking and then to give an example of how one housing association, the CHS Group, is trying to apply this to its social investment work in Cambridgeshire. Along the way, the article seeks to explore some of the related concepts such as co‐production, bartering, and social capital. Its purpose is to brief other housing and social care practitioners about recent developments in thinking and practice around community organisation.Design/methodology/approachThe article summarises key information about time banking, publishes the detail of a proposal to produce a social support time banking project, and draws conclusions about future directions.FindingsThere are numerous questions still to answer, such as: How we can enable all of our staff, resources permitting, to think and act in a community organising way? How best to engage and support customers in participating? How to avoid this being seen solely as a response to cuts in statutory funding, rather than a way of releasing civic potential and capacity to produce a more personalised support? How to reorganise performance management systems to include community organisation? How should staff and organisational time banking be organised in the context of providing closely regulated services, and managing risk while working with vulnerable group? Are there enough people out there who want to, or have the capacity for engagement, and if so how best to reach them?Research limitations/implicationsThis is not unique primary research: the methodology is to use existing published documents and documents from within CHS Group. The article is limited by the absence of statistical data.Practical implicationsThere are some lessons and ideas about how to structure a programme using timebanking to support vulnerable people in communities.Social implicationsFinding the right answers to the questions might assist services providers and customers to navigate through the impending welfare reform and social funding cut backs.Originality/valueThe article explores approaches to time banking used by a variety of agencies including the Department of Health POPP programme as applicable in social housing.
Limits of Mental Capacity Act training for residential care homes
Authors: Gough Matthew , Kerlin Lianne 
Published: November 2012

PurposeThe Mental Capacity Act (MCA) was implemented in 2007 as a piece of legislation to empower and protect adults who require support making decisions. Many older adults in residential care homes will be in this position due to developmental disabilities associated with functional impairments of the mind and brain. This paper aims to evaluate the impact of MCA training within older persons' care homes within an East‐Midlands local authority.Design/methodology/approachSemi structured interviews were conducted with key informants who had strategic responsibility for implementation of MCA training as well as a focus group conducted with managers/deputy managers of care homes within the local authority.FindingsWith a primary focus on training, data revealed issues surrounding the delivery and content of training, and the organisational factors relating to both training and the subsequent implementation of the knowledge learned.Research limitations/implicationsThe key informants for this paper are limited to management perspectives. Interviews and a focus group were conducted with stakeholders who either had direct responsibility for service delivery or managerial oversight for training and development.Practical implicationsThe paper suggests methods of delivery with the Mental Capacity Act which offer a tailored, engaging and cost effective alternative to conventional “away day” training sessions.Originality/valueThe paper challenges and critiques conventional approaches to training the social care workforce.
Going global with health and wellbeing analytics
Authors: Barron Gen 
Published: November 2012

PurposeMedtronic needed a comprehensive, integrated, measurable and global approach to employee wellness. Its primary focus was putting the critical factors of prevention and early detection at the forefront of its employee health rewards. The ability to monitor and measure health and wellbeing across the organization was also vital in giving Medtronic key insight, through analytics, into the impact that employee health had on the business. This paper aims to examine this approach.Design/methodology/approachMedtronic's Total Health global employee wellness brand focused on investing in health rather than the cost of treatment and improving employee health through behavior change. Seeing that the web was critical to delivery and collection of information in this environment it sought an online health and wellbeing platform with the capability to be deployed globally.FindingsInitial health assessments conducted through the online platform have provided essential baseline data to understand overall global health trends as well as territory specific differences and priorities. Medtronic has been able to establish an average employee health score. Digging deeper it has noted priority health indicators for global employees based on the number who are recorded to be “at risk” in each case.Originality/valueSuccessful use of analytics and web‐based tools has helped Medtronic accelerate towards its vision of personalized, consistent wellbeing support for all employees. It now has greater insight into their health status to define the right strategy, and the tools to drive targeted initiatives where they are needed.
What do engagement measures really mean?
Authors: Baron Angela 
Published: November 2012

PurposeThis paper aims to discuss how and with what employees engage at work. It seeks to offer an explanation of “locus of engagement” – what aspects of their work individuals engage with to a lesser or greater extent – and “emotional” and “transactional” engagement – demonstrating that people can engage at different levels, both of which might result in performance but also in very different behaviors.Design/methodology/approachThe paper is based on research completed for CIPD by The Kingston Engagement Consortium drawing on both quantative and qualitative data collected from member companies over a six‐year period of study.FindingsThe paper argues that managers need a deeper understanding of how employees are engaging with their work to effectively leverage performance through engagement. It finds that despite much work on engagement, the issues of with what and at what level people are engaging is still relatively unexplored. It also finds that how and with what people engage can have implications for their performance and other behavior which will impact on the success of the organization.Originality/valueThis has practical implications for managers and demonstrates that engagement surveys alone will not give sufficient information to enable them to manage engagement effectively.
The current state of integrated care: an overview
Authors: Minkman Mirella M.N. 
Published: November 2012

PurposeAlthough a large amount of literature about the levels, aims, and relevance of integrated care is present, to realise change in practice knowledge about the implementation and development process of integrated care is also crucial. Instruments such as quality management models can facilitate improvement, but are not frequently used in integrated care practice. The purpose of this paper, therefore, is to present further insight into these models and into the related literature about network and organisational development.Design/methodology/approachAn overview of the recent literature is presented.FindingsThe improvement of integrated care is complex and there is no consensus about a set of relevant elements for integrated care. Available quality management models vary in their underlying evidence and do not have integrated care as their central focus or are aimed at specific patient groups such as the chronically ill. The lack of a consistent set of elements and the need for a generic, evidence‐based quality management model for integrated care is important for integrated care improvement. It can be assumed that, as described in the literature about networks and organisations, dynamic stages or phases could be relevant for integrated care. These issues raise important next questions for further research and for facilitating organisational change.Originality/valueThe paper presents a current overview of the available literature about the concept of integrated care, with a special focus on integrated care improvement and its dynamics. It raises the relevant questions and challenges for the further expansion of knowledge about these topics, which will be addressed in a second article in a later issue of Journal of Integrated Care.
Implementing the Transforming Your Care agenda in Northern Ireland within integrated structures
Authors: Birrell Derek , Heenan Deirdre 
Published: November 2012

PurposeThis paper assesses the recommendations and proposals contained in Transforming Your Care, the recent review of health and social care in Northern Ireland, in the context of the existing integrated structures. It is designed to promote a better understanding of the implications of the proposed reconfiguration of health and social care.Design/methodology/approachThis paper reviews a number of published documents encompassing an independent review and subsequent plans and strategies. It also draws upon a case study of a Rapid Access Clinic undertaken by the authors as part of a wider research project.FindingsThe paper concludes that the planned changes question the ability of an integrated structure operating across primary, secondary and social care. It notes that there are real concerns about the capacity of the social care workforce to deliver services. It is suggested that the proposal for Integrated Care Partnerships can be seen as a reflection of the need for a more localised approach to delivery.Research limitations/implicationsThe findings are derived from a small‐scale study and as such may make generalisation difficult. There is a clear need for a more robust evidence‐based approach to the evaluation of structural integration in health and social care and a process for monitoring of this change process.Originality/valueThe article is a reminder of the unique example of structural integration within the UK. As such it could have important lessons for England, Scotland and Wales which are moving in a similar direction.
Miaow miaow: a review of the new psychoactive drug mephedrone
Authors: Brennan Rebekah , Claire Van Hout Marie 
Published: November 2012

PurposeMephedrone is a synthetic stimulant drug causing entactogenic and hallucinogenic effects. A systematic review of all existing empirical research and literature from 2009‐2012 on this new psychoactive drug was conducted. This paper aims to report on that review.Design/methodology/approachThe review was conducted according to PRISMA guidelines. Electronic databases were utilised using the search terms “mephedrone” and product nomenclature; “Plant Food”, “Feeder”, “Meow Meow”, “Miaow”, “Drone”, “Meph” “Bubbles”, “Charge”, and “MCat”. The search was restricted to publications from 2009‐2012, and produced 702 results. Data were collected by one member of the research team and cross checked by another. A primary screening was carried out to exclude inaccurate search results and drugs other than mephedrone. The results were studied and duplicates removed; 598 results were discarded, with 104 deemed suitable for inclusion.FindingsThe review underscores mephedrone's popularity despite legislative controls. Drug displacement patterns from illicit to licit were observed prior to controls, with blending of mephedrone and other substitute cathinones with street drugs thereafter. User consumptive choices are grounded in availability, perceptions of legality and safety, curiosity and perceived quality of drug outcomes within poly drug taking repertoires. Clinical reports indicate that mephedrone has high abuse potential and toxicity, with several dependence symptoms. Risk assessment, detection, diagnosis and treatment of mephedrone use are difficult due to polydrug use and associated mental health disorders.Research limitations/implicationsThe review points to the need for further research into the pharmacology and toxicity of mephedrone in order to better equip clinicians with assessment, diagnosis and treatment strategies to reduce morbidity.Practical implicationsThe increasingly diversified new psycho stimulant market where mephedrone is a major player poses unprecedented challenges for drug surveillance, policy, community and clinical practice.Social implicationsStricter legislative controls including internet vendor responsibility for supply of mephedrone have been suggested, along with raising public awareness on an international level through coordinated efforts.Originality/valueThe last review was published in 2009 by the Psychonaut Webmapping Group. This review brings together a comprehensive new set of data sources as they relate to this drug.
Karen refugees from Burma: focus group analysis
Authors: Power David V. , Pratt Rebekah J. 
Published: November 2012

PurposeThis paper's aim is to describe the health experiences of a recently arrived group of refugees, the Karen from Burma, in an American midwestern city.Design/methodology/approachFour focus groups were conducted in their native language with 40 Karen refugees: one group of ten Sgaw Karen speaking men and one of women, one of East Pwo Karen speaking men and one of women. The focus groups and two additional individual interviews were coded using NVivo‐9.FindingsThe findings emphasize the significant communication barriers experienced by the Karen. The data provide rich insights into the struggles being experienced by these new Americans in their own words and highlight some of their differences from previous Asian refugees.Research limitations/implicationsThese data are derived from focus groups with refugees in one city in the USA with few available demographic details. Their experiences and observations may not apply to other Burmese refugee groups in other cities and countries.Practical implicationsThe data emphasize the complexity of language of this group of Burmese refugees which acts as a significant barrier to accessing health care. Poor or improper interpretation has increased obstacles. Data indicate that many struggle with simple health care tasks that are likely taken for granted by most providers. There appears to be more alcohol and tobacco usage amongst both genders than in other recently arrived Asian groups.Originality/valueThis is original research, which supplements a prior chart review and overview paper by the first author and supplements the otherwise scant literature on this group outside Asia.
Health needs and access to care in immigration detention: perceptions of former detainees
Authors: Zimmerman Susan E. , Chatty Dawn , Nørredam Marie Louise 
Published: November 2012

PurposeAs immigration detainee numbers grow, doubts have arisen over the consistency, quality and suitability of the health care services provided among the UK detention estate and in other Western countries. Detained immigrants, due to their past and present situations, may be especially vulnerable in terms of their health. They may simultaneously lack entitlements to care due to their legal situation. Health needs and access to health care services in immigration detention is understudied. Therefore, this exploratory study aims to test the usefulness of a questionnaire among former detainees examining perceptions of their health needs and access to care within immigration detention in the UK.Design/methodology/approachIn total, 30 former detainees completed questionnaires, and 27 of these also participated in semi‐structured interviews, in June/July 2010. Frequency analyses of questionnaire responses were performed.FindingsThe results showed that 66 per cent of the participants entered detention with pre‐existing mental or physical health conditions that required ongoing or new treatments. In addition, new mental/emotional (93 per cent) or physical (53 per cent) health problems arose for the majority of the participants within detention.Research limitations/implicationsAccess to health care in detention was often problematic in its effectiveness or availability due to a variety of formal and informal challenges.Originality/valueThe results of this exploratory study cast doubt on how appropriately the mental and physical health needs of detainees are being provided for within the current UK detention estate.