bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported fatigue and its impact on patients with systemic lupus erythematosus
Authors: Sterling KL , Gallop K , Swinburn P , Flood E , French A , Sawah S Al , Iikuni N , Naegeli AN , Nixon A 
Published: November 2013

Fatigue is a hallmark symptom of systemic lupus erythematosus (SLE), often associated with flares, side effects of treatment, and extensive organ damage and may have a significant impact on health-related quality of life (HrQoL). To date, the experience of fatigue in patients with SLE is underexplored. This study explored the experience of fatigue in patients with SLE and its impact on their lives through qualitative interviews. This cross-sectional qualitative study was conducted with 22 adult patients with SLE, recruited from two clinical sites in the United States. In-person semi-structured interviews were conducted and thematic analysis was performed focusing on the experience of fatigue in SLE. Results indicated that 21 out of 22 patients experienced fatigue due to SLE. Patients reported that fatigue was variable in nature in terms of both severity and frequency. Fatigue was described as having an impact on multiple aspects of a patient’s life: emotions, cognition, work, activities of daily living, leisure activities, social activities, and family activities. Understanding how patients with SLE describe the symptom of fatigue and how it impacts their lives is the key to better understanding how to measure fatigue in clinical studies evaluating new treatments for SLE.
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
Authors: Thompson A. A. Roger , Elks Philip M. , Marriott Helen M. , Eamsamarng Suttida , Higgins Kathryn R. , Lewis Amy , Williams Lynne , Parmar Selina , Shaw Gary , McGrath Emmet E. , Formenti Federico , Van Eeden Fredericus J. , Kinnula Vuokko L. , Pugh Christopher W. , Sabroe Ian , Dockrell David H. , Chilvers Edwin R. , Robbins Peter A. , Percy Melanie J. , Simon M. Celeste , Johnson Randall S. , Renshaw Stephen A. , Whyte Moira K. B. , Walmsley Sarah R. 
Published: November 2013

Key PointsNeutrophil lifespan is extended in patients with gain-of-function HIF2A mutations. HIF-2α regulates in vivo neutrophil longevity and thus tissue inflammation and repair.
VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice
Authors: Savchenko Alexander S. , Borissoff Julian I. , Martinod Kimberly , De Meyer Simon F. , Gallant Maureen , Erpenbeck Luise , Brill Alexander , Wang Yanming , Wagner Denisa D. 
Published: November 2013

Key Points
PAD4-mediated chromatin decondensation and release by neutrophils exacerbate injury after MI/R. Combining reduction of neutrophil recruitment with extracellular DNA cleavage could be a new approach to reduce cardiac damage after MI.
Periodic solutions for a class of diffusive Nicholson’s blowflies model with Dirichlet boundary conditions
Authors: Liu Bingwen , Meng Junxia , Jiao Weidong 
Published: November 2013

Abstract
In this paper, we study the problem of periodic solutions for a class of diffusive Nicholson’s blowflies model with Dirichlet boundary conditions. By applying the Schauder fixed point theorem, the existence of nontrivial nonnegative periodic solutions of the considered model is established. Our results complement with some recent ones.

MSC:35B05, 35B10.
Common fixed point results for weak contractive mappings in ordered b-dislocated metric spaces with applications
Authors: Hussain Nawab , Roshan Jamal Rezaei , Parvaneh Vahid , Abbas Mujahid 
Published: November 2013

Abstract
We first introduce a new concept of b-dislocated metric space as a generalization of dislocated metric space and analyze different properties of such spaces. A fundamental result for the convergence of sequences in b-dislocated metric spaces is established and is employed to prove some common fixed point results for four mappings satisfying the generalized weak contractive condition in partially ordered b-dislocated metric spaces. Moreover, some examples and applications to integral equations are given here to illustrate the usability of the obtained results.

MSC:47H10, 54H25.
Global regularity for solutions of a class of quasilinear elliptic equations
Authors: Lu Yueming , Wang Tingting , Bao Gejun , Li Guanfeng 
Published: November 2013

Abstract
We derive interior and global Hölder estimates for solutions of a class of quasilinear elliptic equations. First, the interior Hölder continuity is obtained by the iteration of an oscillation estimate. Then, the Hölder continuity up to the boundary is established in domains with certain boundary constraints. Last, we prove the global Hölder continuity of solutions provided that their restrictions on boundary are Hölder continuous. The concluding section presents an application to illustrate our main results.

MSC:35B65, 35J60.
Interferon-inducible chemokines reflect severity and progression in sarcoidosis
Authors: Su Robert , Nguyen Michelle-Linh T , Agarwal Misha R , Kirby Christopher , Nguyen Christine P , Ramstein Joris , Darnell Eli P , Gomez Antonio D , Ho Melissa , Woodruff Prescott G , Koth Laura L 
Published: November 2013

AbstractBackgroundIdentification of serum proteins that track with disease course in sarcoidosis may have clinical and pathologic importance. We previously identified up-regulated transcripts for interferon-inducible chemokines CXCL9, and CXCL10, in blood of sarcoidosis patients compared to controls. The objective of this study was to determine whether proteins encoded by these transcripts were elevated in serum and identified patients with remitting vs. chronic progressive sarcoidosis longitudinally.MethodsSerum levels of CXCL9, CXCL10, and proteins associated with inflammation and/or disease activity (sIL2R, ACE, ESR and CRP) were measured in a prospective cohort of sarcoidosis subjects and controls. Comparisons were made between groups and clinical course using pulmonary function measures and a severity score developed by Wasfiet al.ResultsIn a cross-sectional analysis of 36 non-immunosuppressed sarcoidosis subjects, serum CXCL9, CXCL10, and sIL2R were significantly elevated compared to 46 controls (p < 0.0001). CXCL9 and CXCL10 were strongly inter-correlated (p = 0.0009). CXCL10 and CXCL9 were inversely correlated with FVC% predicted and DLCO% predicted, respectively. CXCL10 and CXCL9 significantly correlated with sarcoidosis severity score. sIL2R, ESR, CRP, and ACE serum levels did not correlate with pulmonary function measures or severity score. In the longitudinal analysis of 26 subjects, changes in serum CXCL10 level over time corresponded with progression versus remission of disease.ConclusionsInterferon-γ–inducible chemokines, CXCL9 and CXCL10, are elevated in sarcoidosis and inter-correlated with each other. Chemokine levels correlated with measures of disease severity. Serial measurements of CXCL10 corresponded to clinical course.
Resistance to treatment and change in anorexia nervosa: a clinical overview
Authors: Abbate-Daga Giovanni , Amianto Federico , Delsedime Nadia , De-Bacco Carlotta , Fassino Secondo 
Published: November 2013

AbstractBackgroundCurrent literature on Eating Disorders (EDs) is devoid of evidence-based findings providing support to effective treatments, mostly for anorexia nervosa (AN). This lack of successful guidelines may play a role in making these disorders even more resistant. In fact, many individuals do not respond to the available treatments and develop an enduring and disabling illness. With this overview we aimed to highlight and discuss treatment resistance in AN – with an in-depth investigation of resistance-related psychological factors.A literature search was conducted on PubMed and PsychINFO; English-language articles published between 1990 and 2013 investigating the phenomenon of resistance to treatment in AN have been considered.DiscussionThe selected papers have been then grouped into four main thematic areas: denial of illness; motivation to change; maintaining factors and treatment outcome; and therapeutic relationship. Eating symptomatology was found to only partially explain resistance to treatment. The role of duration of illness has been questioned whilst some maintaining factors seemed promising in providing a useful framework for this phenomenon. Emotive and relational aspects have been investigated on their role in resistance as well as therapists’ countertransference.SummaryRemarkably there has been little research done on resistance to treatment in the ED field, in spite of its clinical relevance. Motivation, insight and subjective meaning of the illness can be useful tools to manage the resistance phenomenon when coupled with a wider approach. The latter enables the therapists to be aware of their role in the therapeutic alliance through countertransference aspects and to consider the EDs as disorders of the development of both personality and self, entailing severe impairments as regards identity and relationships.
Association between diabetes-related factors and clinical periodontal parameters in type-2 diabetes mellitus
Authors: Kim Eun-Kyong , Lee Sang Gyu , Choi Youn-Hee , Won Kyu-Chang , Moon Jun Sung , Merchant Anwar T , Lee Hee-Kyung 
Published: November 2013

Abstract

Background
Evidence consistently shows that diabetes is a risk factor for increased prevalence of gingivitis and periodontitis. But there is a controversy about the relationship between diabetes related factors and periodontal health. The aim of the present study is to explore the relationship between diabetes related factors such as glycosylated hemoglobin, fasting blood glucose, duration of diabetes and compliance to diabetes self management and periodontal health status.

Methods
Periodontal health of 125 participants with type-2 diabetes mellitus was measured by the number of missing teeth, community periodontal index (CPI), Russell’s periodontal index and papillary bleeding index. Information on sociodemographic factors, oral hygiene behavior, duration and compliance to self management of diabetes, levels of glycosylated hemoglobin(HbA1c) and fasting blood glucose(FBG) were collected by interview and hospital medical records. Statistically, independent t-test, an analysis of variance (ANOVA), chi-squared test and multiple regression analyses were used to assess the association between diabetes-related factors and periodontal health.

Results
Periodontal parameters including the number of missing teeth and papillary bleeding index were significantly influenced by duration of diabetes, FBG and compliance to self management of diabetes. CPI was significantly influenced by duration of diabetes, FBG and HbA1C. And Russell’s periodontal index was significantly influenced by duration of diabetes, FBG, HbA1C and compliance to self management of diabetes. Results of multiple linear regression analysis showed that the duration of diabetes showed significant positive correlation with all of the periodontal health parameters, except for missing teeth. HbA1c was correlated with Russell's periodontal and papillary bleeding index. FBG and compliance to self management of diabetes were correlated with missing teeth and papillary bleeding index respectively.

Conclusions
Diabetes-related factors such as duration of diabetes, FBG, HbA1c and compliance to self management of diabetes were significantly correlated with periodontal health among individuals with type-2 diabetes.
Iteration scheme for common fixed points of hemicontractive and nonexpansive operators in Banach spaces
Authors: Hussain Nawab , Sahu DR , Rafiq Arif 
Published: November 2013

Abstract
The purpose of this paper is to characterize the conditions for the convergence of the iterative scheme in the sense of Agarwal et al. (J. Nonlinear Convex. Anal. 8(1): 61-79, 2007), associated with nonexpansive and ϕ-hemicontractive mappings in a nonempty convex subset of an arbitrary Banach space.
New approach to twisted q-Bernoulli polynomials
Authors: Kim Daeyeoul , Koo Ja Kyung , Park Yoon Kyung 
Published: November 2013

Abstract
By using the theory of basic hypergeometric series, we present some formulas for q-consecutive integers, and we find certain new identities for twisted q-Bernoulli polynomials and q-consecutive integers (Simsek in Adv. Stud. Contemp. Math. 16(2):251-278, 2008).

MSC: 11B68, 05A30.
Recurrent cutaneous necrotizing eosinophilic vasculitis: a case report and review of the literature
Authors: Li Wenfei , Cao Wang , Song Haiyan , Ciu Yanxia , Lu Xianmei , Zhang Furen 
Published: November 2013

Abstract
We report a case of recurrent cutaneous necrotizing eosinophilic vasculitis (RCNEV) in a 57-year-old male. The patient presented with papules and pruritus of the lower limbs of more than 1 month duration, and with angioedema and intensively pruritic, necrotizing lesions of the bilateral anterior tibias and feet for 2 weeks. Treatment with systemic corticosteroids was administered for 1 month, and resulted in a significant improvement. We also present a review of the pertinent literature and discuss the clinical features, histopathological features, and differentiation of RCNEV.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2065600765102207
Complete excision of a giant thyroid goiter in posterior mediastinum
Authors: Chen Xin , Xu Hongfei , Ni Yiming , Sun Ke , Li Weidong 
Published: November 2013

Abstract
Intrathoracic goiter is commonly located in the anterior mediastinum. Here we report a case of a 58-year-old Chinese male in whom we successfully removed the intrathoracic goiter and eased his dyspnea by a right posterolateral thoracotomy approach. Posterior mediastinal thyroid goiter with mediastinal compressive symptoms is an indication of surgery.
Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer
Authors: Li Kening , Li Zihui , Zhao Ning , Xu Yaoqun , Liu Yongjing , Zhou Yuanshuai , Shang Desi , Qiu Fujun , Zhang Rui , Chang Zhiqiang , Xu Yan 
Published: November 2013

Abstract

Background
Lung cancer, especially non-small cell lung cancer, is a leading cause of malignant tumor death worldwide. Understanding the mechanisms employed by the main regulators, such as microRNAs (miRNAs) and transcription factors (TFs), still remains elusive. The patterns of their cooperation and biological functions in the synergistic regulatory network have rarely been studied.

Results
Here, we describe the first miRNA-TF synergistic regulation network in human lung cancer. We identified important regulators (MYC, NFKB1, miR-590, and miR-570) and significant miRNA-TF synergistic regulatory motifs by random simulations. The two most significant motifs were the co-regulation of miRNAs and TFs, and TF-mediated cascade regulation. We also developed an algorithm to uncover the biological functions of the human lung cancer miRNA-TF synergistic regulatory network (regulation of apoptosis, cellular protein metabolic process, and cell cycle), and the specific functions of each miRNA-TF synergistic subnetwork. We found that the miR-17 family exerted important effects in the regulation of non-small cell lung cancer, such as in proliferation and cell cycle regulation by targeting the retinoblastoma protein (RB1) and forming a feed forward loop with the E2F1 TF. We proposed a model for the miR-17 family, E2F1, and RB1 to demonstrate their potential roles in the occurrence and development of non-small cell lung cancer.

Conclusions
This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies.
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
Authors: Dolfi Sonia C , Chan Leo Li-Ying , Qiu Jean , Tedeschi Philip M , Bertino Joseph R , Hirshfield Kim M , Oltvai Zoltán N , Vazquez Alexei 
Published: November 2013

Abstract

Background
Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that this inconsistency is rooted in the variability of cell size.

Results
We integrate previously reported data characterizing genome copy number variations, gene expression, protein expression and exchange fluxes with our own measurements of cell size and protein content in the NCI60 panel of cell lines. We show that protein content, DNA content, and protein synthesis per cell are proportional to the cell volume, and that larger cells proliferate slower than smaller cells. We estimate the metabolic fluxes of these cell lines and show that their magnitudes are proportional to their protein synthesis rate and, after correcting for cell volume, to their proliferation rate. At the level of gene expression, we observe that genes expressed at higher levels in smaller cells are enriched for genes involved in cell cycle, while genes expressed at higher levels in large cells are enriched for genes expressed in mesenchymal cells. The latter finding is further corroborated by the induction of those same genes following treatment with TGFβ, and the high vimentin but low E-cadherin protein levels in the larger cells. We also find that aromatase inhibitors, statins and mTOR inhibitors preferentially inhibit the in vitro growth of cancer cells with high protein synthesis rates per cell.

Conclusions
The NCI60 cell lines display various metabolic activities, and the type of metabolic activity that they possess correlates with their cell volume and protein content. In addition to cell proliferation, cell volume and/or biomarkers of protein synthesis may predict response to drugs targeting cancer metabolism.
Return migration and the age profile of
retirement among immigrants
Authors: Cobb-Clark Deborah A , Stillman Steven 
Published: November 2013

AbstractWe analyze the relationship between the age profile of retirement
within an immigrant population and aggregate return migration rates for individuals
from different countries of origin. The latter serves as a proxy for the relative
net benefits of return migration to that origin country. Our simple theoretical
model illustrates that under reasonable conditions the probability of return
migration is maximized at retirement. This implies that different immigrant
populations will have different retirement profiles, not only because individual
retirement behavior differs, but also because the propensity for return migration
varies. Consistent with our theoretical model, we estimate a negative relationship
between immigrants’ retirement status and the aggregate return migration rate of
their fellow countrymen. As theory suggests, this link is strongest for immigrants
who are near the retirement age.
JEL codes
J260, J010, J080
Group multi-criteria decision making using intuitionistic multi-fuzzy sets
Authors: Das Sujit , Kar Mohuya B , Kar Samarjit 
Published: November 2013

AbstractIn this paper we propose an efficient approach for group multi-criteria decision making (MCDM) based on intuitionistic multi-fuzzy set (IMFS). First we construct intuitionistic multi-fuzzy matrices for decision makers with respect to the criteria (attributes) of the alternatives. Based on intuitionistic multi-fuzzy matrices, we construct the aggregated intuitionistic multi-fuzzy matrix using the proposed intuitionistic multi-fuzzy weighted averaging (IMFWA) operator. Then we use Hamming distance and Euclidean distance measurements in the context of IMFS between the aggregated matrix and the specified sample matrix to reach the optimal decision. This paper also presents score function and accuracy function of IMFS with an application to MCDM. Finally, a real-life case study related to heart disease diagnosis problem is provided to illustrate the advantage of the proposed approach.
Metabolic reprogramming by viruses in the sunlit and dark ocean
Authors: Hurwitz Bonnie L , Hallam Steven J , Sullivan Matthew B 
Published: November 2013

Abstract
Background
Marine ecosystem function is largely determined by matter and energy transformations mediated by microbial community interaction networks. Viral infection modulates network properties through mortality, gene transfer and metabolic reprogramming.

Results
Here we explore the nature and extent of viral metabolic reprogramming throughout the Pacific Ocean depth continuum. We describe 35 marine viral gene families with potential to reprogram metabolic flux through central metabolic pathways recovered from Pacific Ocean waters. Four of these families have been previously reported but 31 are novel. These known and new carbon pathway auxiliary metabolic genes were recovered from a total of 22 viral metagenomes in which viral auxiliary metabolic genes were differentiated from low-level cellular DNA inputs based on small subunit ribosomal RNA gene content, taxonomy, fragment recruitment and genomic context information. Auxiliary metabolic gene distribution patterns reveal that marine viruses target overlapping, but relatively distinct pathways in sunlit and dark ocean waters to redirect host carbon flux towards energy production and viral genome replication under low nutrient, niche-differentiated conditions throughout the depth continuum.

Conclusions
Given half of ocean microbes are infected by viruses at any given time, these findings of broad viral metabolic reprogramming suggest the need for renewed consideration of viruses in global ocean carbon models.
AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation
Authors: Aldridge Sarah , Watt Stephen , Quail Michael A , Rayner Tim , Lukk Margus , Bimson Michael F , Gaffney Daniel , Odom Duncan T 
Published: November 2013

AbstractChIP-seq is an established manually-performed method for identifying DNA-protein interactions genome-wide. Here, we describe a protocol for automated high-throughput (AHT) ChIP-seq. To demonstrate the quality of data obtained using AHT-ChIP-seq, we applied it to five proteins in mouse livers using a single 96-well plate, demonstrating an extremely high degree of qualitative and quantitative reproducibility among biological and technical replicates. We estimated the optimum and minimum recommended cell numbers required to perform AHT-ChIP-seq by running an additional plate using HepG2 and MCF7 cells. With this protocol, commercially available robotics can perform four hundred experiments in five days.