bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of kakkatin derivatives and their anti-tumor activity
Authors: Jiang Yu-Ying , Dong Hui-Hua , Zhou Wen-Ting , Luo Jia-Zi , Wei Xian , Huang Yan-Qiang 
Published: August 2024

BACKGROUND
Modern pharmacological studies have confirmed that plant-derived compounds from Puerariae flos (PF) has significant biological activities against liver damage, tumors and inflammation. Kakkatin is an isoflavone polyphenolic compound isolated from PF flower. However, the effect of kakkatin and its derivatives on anti-tumor has not been well explored.
AIM
To design and synthesize a kakkatin derivative [6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one (HK)] to explore its anti-tumor biological activity.
METHODS
Hept-6-yn-1-yl ethanesulfonate was introduced to replace hydrogen at the hydroxyl position of kakkatin phenol, and the derivative of kakkatin was prepared; the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide was used to detect cell viability, a clone formation assay was adopted to detect cell proliferation, apoptosis, necrosis, and cell cycles were analyzed by Annexin V/propidium iodide staining and flow cytometry. Cell migration and invasion ability were evaluated by cell scratch assay and transwell assay. The potential mechanism of HK on hepatocellular carcinoma (HCC) SMMC-7721 cells was explored through network pharmacology and molecular docking, and finally real-time PCR assays was used to verify the potential targets and evaluate the biological activity of HK.
RESULTS
Compared with kakkatin, the modified HK did not significantly increase the inhibitory activity of gastric cancer MGC803 cells, but the inhibitory activity of HCC SMMC-7721 cells was increased by about 30 times, with an IC50 value of 2.5 μM, and the tumor inhibition effect was better than cisplatin, which could significantly inhibit the cloning, invasion and metastasis of HCC SMMC-7721 cells, and induce apoptosis and G2/M cycle arrest. Its mechanism of action is mainly related to the upregulation of PDE3B and NFKB1 target proteins in the cAMP pathway.
CONCLUSION
HK have a significant inhibitory effect on HCC SMMC-7721 cells, and the targets of their action may be PDE3B and NFKB1 proteins in the cAMP pathway, making it a good lead drug for the treatment of HCC.
Non-Hodgkin's lymphoma involving chronic difficult-to-heal wounds: A case report
Authors: Zhang Pei-Shen , Wang Rong , Wu Hu-Wen , Zhou Han , Deng Han-Bin , Fan Wen-Xuan , Li Jia-Cheng , Cheng Shao-Wen 
Published: August 2024

BACKGROUND
Non-Hodgkin's lymphoma (NHL) is a malignant tumor that originates from the lymphoid tissues and can potentially affect numerous organs within the body. Among these, the skin stands out as one of the primary sites affected by NHL, often presenting with multiple extra-nodal manifestations. In this report, we present an unusual case of NHL involving chronic wounds in the lower extremities that were difficult to heal. The scars were successfully treated using radiotherapy in combination with extended excision debridement and peroneal artery perforator flap grafting, resulting in satisfactory outcomes.
CASE SUMMARY
A 19-year-old male patient presented with ulceration of the skin on the left calf near the ankle accompanied by purulent discharge. Subsequent pathologic biopsy confirmed a diagnosis of NHL (extranodal NK/T-cell lymphoma, nasal type). Initial treatment comprised local radiotherapy and wound care; however, the wound exhibited prolonged non-healing. Consequently, the patient underwent a series of interventions including radiotherapy, wound enlargement excision debridement, and peroneal artery perforator flap grafting. Ultimately, successful healing was achieved with favorable postoperative outcomes characterized by good texture of the flap without any signs of rupture or infection.
CONCLUSION
The combination of radiotherapy, wound enlargement excision debridement, and peroneal artery perforator flap grafting may present a favorable treatment modality for chronic non-healing lower leg wounds resulting from NHL.
Peran DPK dalam memoderasi pembiayaan murabahah pada bank umum syariah
Authors: Sari Deny Kurnia , Annisa Arna Asna 
Published: August 2024

This research aims to determine the effect of non-performing financing, net operating margin and financing-to-deposit ratio on murabahah financing with third-party funds as a moderating variable in Islamic commercial banks in Indonesia. This type of research is quantitative and involves a population of Islamic commercial banks registered with the Financial Services Authority (OJK). Meanwhile, the sample for this research was determined using a purposive sampling method with criteria determined by the researcher so that 60 samples were obtained from 12 Islamic commercial banks in 2016–2020. The type of data used is panel data. The analysis method used is moderated regression analysis (MRA). The research results show that the NPF and NOM variables hurt murabahah financing. Meanwhile, FDR hurts murabahah financing. DPK, as a moderating variable, is able to moderate the relationship between NPF, NOM and FDR variables on murabahah financing with varying results.
Eksplorasi Etnomatematika Permainan Tradisional Kartu Wayang Umbul
Authors: Hasanah Uswatun , Basri Hasan , Muplihah Muplihah , Ramadhani Ahmad Rizky 
Published: August 2024

Tujuan penelitian ini adalah untuk menganalisis dan mendeskripsikan unsur- unsur etnomatematika pada permainan tradisional kartu wayang umbul. Penelitian ini dilakukan dengan metode penelitian kualitatif dengan menggunakan pendekatan etnografi. Instrument pada penelitian ini adalah mengumpulkan data, literatur, dokumentasi, observasi dan wawancara. Etnomatematika pada permainan tradisional kartu wayang umbul diidentifikasi melalui observasi dan dokumentasi, dan nilai-nilai budaya yang ada melalui wawancara dan literatur. Hasil penelitian menunjukkan bahwa pada permainan tradisional kartu wayang umbul terdapat beberapa unsur-unsur matematika (etnomatematika), yaitu: konsep bangun datar, konsep bilangan bulat positif, sifat kongruensi, operasi pembagian, konsep bilangan/angka satuan, dan konsep perbandingan. Melalui kegiatan permainan kartu wayang umbul dalam pembelajaran matematika nampak bahwa permainan tradisonal kartu wayang umbul dapat digunakan untuk mengajar matematika dengan cara yang lebih kontekstual.
Implementasi Aplikasi Company Profile Desa Agrowisata Berbasis Android
Authors: Putra Andre Mariza 
Published: August 2024

Pariwisata menjadi slah satu sektor yang menyumbang kemajuan ekonomi. Salah satu jenis pariwisata yang mulai banyak diminati wisatawan adalah Agrowisata. Agrowisata memiliki beragam variasi, seperti menawarkan pembelajaran di bidang teknologi agronomi, perkebunan, perikanan, petemakan, juga sebagai sarana hiburan masyarakat sekitar. Namun keterbatasan jangkauan promosi dari pengelola maupun pemilik menjadikan jenis wisata ini belum banyak diketahui. Aplikasi company profile diharapkan dapat menjadi salah satu media promosi untuk memperkenalkan agrowisata tersebut. Aplikasi dibuat berbasis android karena masyarakat rerata merupakan pengguna android saat ini. Harapanya dengan adanya aplikasi tersebut, agrowisata dapat diketahui masyarakat luas dan menjadi salah satu tujuan wisatawan untuk berlibur
Structured Reflection Tasks for Transformative Language and Culture Learning
Authors: Fabbian Chiara , Carney Emanuela Zanotti 
Published: August 2024

Abstract
Drawing on research at the intersection of adult transformative learning and language education, this article argues that by triggering metacognitive processes, language awareness, and perspective transformation, structured reflection (SR) tasks across language and culture curricula contribute to the development of learners as interculturally competent world citizens rather than global human capital. As their learning objectives align with the 2022 Council of Europe's recommendations on intercultural education, SR should be part and parcel of teachers’ training. This qualitative study seeks to offer a theoretical framework and a discussion of best practices to help educators implement SR tasks into the language curriculum.
Friends or Foes: Gendered Environmental Relationships in Italo Calvino's La Speculazione Edilizia
Authors: Santucci Daniele 
Published: August 2024

Abstract
In this article, I conduct an analysis of the characters of Italo Calvino's La speculazione edilizia. I specifically focus on their relationship with the natural environment to highlight gender-related differences. I argue that while men are more inclined to be seduced by the material gain of real estate speculation that damages the environment, women actively demonstrate their commitment to environmental protection and display a strong connection to nature that is neither subordinate nor passive. Through my analysis, I demonstrate how women offer male characters a chance for redemption through the awakening of their emotions, in a consistent effort to establish a human relationship that parallels the retrieval of a lost environmental one.
FREQUENCY OF CLINICAL SYNDROMES IN CHILDREN WITH CONGENITAL HEART DEFECTS ADMITTED AT TERTIARY CARE HOSPITAL
Authors: REHMAN ZU , HAMID M , KHAN A , GUL S , ALI S , AHMAD I , ULLAH S 
Published: August 2024

Congenital Heart Disease, more commonly known as CHD, is among the most common forms of heart disease that affect children as well as adults. Objective: The study's primary purpose is to find the frequency of clinical syndromes in children with congenital heart defects admitted at tertiary care hospitals. Methods: This retrospective observational study was conducted at MMC Teaching Hospital Peshawar from January 2023 to June 2023. Data were collected from 295 patients suffering from CHD and admitted at tertiary care hospitals. Children aged 0-18 years and with confirmed diagnosis of CHDs via echocardiography, cardiac MRI, or cardiac catheterization were included in the study. Patients who underwent heart surgery before initial diagnosis at the study hospital were excluded. Data were collected from hospital records, including demographic information, clinical presentation, type of congenital heart defect, associated clinical syndromes, and comorbidities. Results: Data were collected from 295 patients. Patients with congenital heart defects (CHDs) were young children, with 64.4% aged between 0 to 5 years. There was a slight male predominance, accounting for 54.2% of the patients. Cyanosis was most prevalent in patients with Tetralogy of Fallot (77.8%), while heart failure was commonly observed in those with Ventricular Septal Defect (44.4%) and Coarctation of the Aorta (50.0%). Growth retardation was significantly associated with Tetralogy of Fallot (44.4%) and Ventricular Septal Defect (27.8%). Conclusion: It is concluded that children with congenital heart defects experience a high frequency of clinical syndromes, necessitating early diagnosis and specialized, multidisciplinary care. Tailored management strategies based on specific CHD types can significantly improve these patients' health outcomes and quality of life.
PENGARUH BESARNYA PEMBIAYAAN MUDHARABAH TERHADAP PENDAPATAN USAHA ANGGOTA DI KOPERASI SYARI’AH LAKSANAMEKAR KECAMATAN PADALARANG KABUPATEN BANDUNG BARAT PERIODE TAHUN 2015 SAMPAI DENGAN TAHUN 2019
Authors: Rusdiani Meri 
Published: August 2024

Koperasi Syariah Laksanamekar Kecamatan Padalarang Kabupaten Bandung Barat merupakan salah satu Koperasi Syariah yang menjadi salah satu alternative tempat atau lembaga peminjaman dan pembiayaan bagi para pedagang dan masyarakat sekitar. Salah satu bentuk pembiayaan yang mendominasi adalah pembiayaan mudharabah. Melalui pembiayaan mudharabah diharapkan mampu mempunyai efek yang sangat kuat dalam menjalankan misinya dan dapat mengurangi ketergantungan pengusaha kecil dari lembaga-lembaga keuangan informal yang bunganya relatif terlalu tinggi. Sebelum melakukan transaksi pembiayaan antara pihak Koperasi Syariah dengan nasabah, untuk menentukan bagi hasil maka akan ada kesepakatan yang harus disetujui oleh kedua belah pihak, dan kesepakatan tersebut tertuang dalam sebuah akad pembiayaan. Dengan menggunakan metode penelitian deskriptif, penulis berusaha untuk memecahkan masalah yang dihadapi pada masa sekarang. Deskripsi sebagai gambaran dari desain penelitian yang mana untuk mengetahui perspektif atau suatu kerangka acuan dan memandang sesuatu teori yang diajukan dalam penelitian melalui pendugaan pengujian hipotesis dan untuk mengetahui ada tidaknya pengaruh antara variabel pembiayaan (variable bebas X) terhadap pendapatan usaha anggota koperasi (variable terikat Y). Secara operasional variabel ini bertujuan agar tidak terjadi kesalah pahaman dalam interpretasi, serta untuk mendapatkan pengertian yang sama terhadap istilah yang digunakan pada judul penelitian.
STRATEGI BIRO ADMINISTRASI PIMPINAN SETDA PROVINSI SUMATERA BARAT DALAM MENGELOLA MEDIA SOSIAL INSTAGRAM @HUMAS.SUMBAR
Authors: Dzikra Khaira Ansury  , Amalia Djuwita  
Published: August 2024

Pemerintah memiliki tanggung jawab dalam mengkomunikasikan program pemerintahan. Penyampaian informasi di media sosial saat ini merupakan pemanfaatan fungsi manajemen humas pemerintahan. Dalam menjalankan fungsi manajemen tentunya humas pemerintah memerlukan strategi. Riset penelitian ini membahas mengenai Strategi Biro Administrasi Pimpinan dalam mengelola akun media sosial Instagram @humas.Sumbar. Tujuan dari riset penelitian ini untuk mengetahui bagaimana Strategi Biro Administrasi Pimpinan Setda Provinsi Sumatera Barat dalam mengelola media sosial Instagram @humas.sumbar. Riset penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif, pengumpulan hasil data riset ini diperoleh melalui wawancara, observasi dan dokumentasi. Riset penelitian ini menggunakan teori strategi humas dalam pengelolaan media sosial oleh Regina Luttrell yaitu The Circular Model of SoMe, terdapat empat aspek tahapan-tahapan yang terdiri dari Share (berbagi), Optimize (Optimalisasi), Manage (Mengelola) dan Engage (Melibatkan). Hasil Penelitian menyatakan bahwa Biro Administrasi Pimpinan Setda Provinsi Sumatera Barat sudah menerapkan strategi pengelolaan media sosial dan mengimplementasikan dengan menggunakan teori The Circular Model of SoMe yang dilakukan terdiri dari empat tahap, yakni (1) share dengan membagikan informasi melalui media sosial Instagram @humas.sumbar; (2) Optimize mengoptimalkan dalam perencanaan konten; (3) Manage mengeolola Instagram melalui monitoring; (4) Engage melibatkan audiens.
KETERLIBATAN AYAH DALAM PENGASUHAN ANAK USIA DINI MENURUT PERSPEKTIF IBU
Authors: Esterilita Mari , Utami Nazera Nur 
Published: August 2024

Ibu adalah individu yang paling dekat dan mampu menilai keterlibatan ayah dalam pengasuhan anak secara langsung. Perspektif ibu mengenai pengasuhan anak oleh ayah menjadi penting untuk memahami seberapa besar keterlibatan ayah dalam pengasuhan, yang dapat mempengaruhi realisasi dan harapan ibu terkait pembagian beban pengasuhan. Keterlibatan ayah dalam pengasuhan memberikan dampak positif, tidak hanya pada perkembangan anak, tetapi juga pada pemulihan mental ibu pasca melahirkan, serta menjaga keharmonisan dalam pernikahan. Penelitian ini bertujuan untuk mengukur sejauh mana keterlibatan ayah dalam pengasuhan anak menurut pandangan ibu. Penelitian ini menggunakan pendekatan kuantitatif dengan analisis deskriptif, dan data dikumpulkan melalui penyebaran kuesioner dengan skala Likert. Populasi dan sampel penelitian terdiri dari 19 responden, yaitu ibu yang memiliki balita usia 1-3 tahun dan tinggal di RW 07 Kelurahan Rancamaya, Kabupaten Bogor. Teknik pengambilan sampel yang digunakan adalah purposive sampling. Hasil penelitian menunjukkan bahwa keterlibatan ayah dalam pengasuhan anak bervariasi pada berbagai aspek. Pada aspek komunikasi, 47,4% ayah terlibat; pada aspek mengajarkan, 52,6% ayah terlibat; pada aspek pengawasan, 36,8% ayah terlibat; pada aspek proses kognitif, 42,1% ayah cukup terlibat; pada aspek mengurus, 42,1% ayah terlibat; pada aspek perawatan anak, 36,8% ayah kurang terlibat; pada aspek berbagi pengalaman, 42,1% ayah cukup terlibat; pada aspek mampu hadir dan menunjukkan keberadaan bagi anak, 47,4% ayah kurang terlibat; pada aspek perencanaan, 47,4% ayah terlibat; pada aspek berbagi aktivitas menyenangkan bersama, 47,4% ayah terlibat; pada aspek mempersiapkan kegiatan, 47,7% ayah terlibat; pada aspek memberikan kasih sayang dan sentuhan emosional, 36,8% ayah terlibat; pada aspek memberikan perlindungan, 42,1% ayah sangat terlibat; dan pada aspek memberikan dukungan emosional, 42,1% ayah terlibat. Kesimpulan dari penelitian ini adalah bahwa ayah terlibat dalam berbagai aspek pengasuhan anak. Namun, pada aspek proses kognitif, perawatan anak, berbagi pengalaman, dan keberadaan yang nyata bagi anak, keterlibatan ayah masih kurang dan perlu ditingkatkan.
Manajemen Program Arabic Culture Dalam Menciptakan Bi’ah Arabiyah Di Perguruan Tinggi Islam
Authors: Jazilah Ela , Mufidah Nuril 
Published: August 2024

This research aims to describe the management of the Arabic Culture Program run by an Islamic university in Indonesia, UIN KHAS Jember. This university has succeeded in developing an Arabic Culture program which can create an Arabic language environment (bi'ah Arabiyah), thus producing a generation of achievers in the field of Arabic. The research focuses on exploring planning and implementation activities and looking for supporting and inhibiting factors in implementing the program. The research uses a descriptive qualitative type, with data collection techniques using observation and interviews. In-depth interviews were conducted with the President of International Culture and Islamic Studies (ICIS), the head of the Arabic language division, tutors and program participants. Using Miles and Huberman data analysis, the results of the research show that: program planning is carried out through reviewing division goals and organizational mottos. Next, classes are grouped according to the level of Arabic language skills. 2) This program is implemented for 1 year with 2 meetings in 1 week with peer tutors who have better abilities than other friends, using material according to ability, based on strategies levels and direct methods as well as collaborative systems. 3) Supporting factors for program effectiveness come from tutor competence, shared goals of program participants and support from leaders. Meanwhile, obstacles come from the low commitment of tutors and participants, limited infrastructure (learning places), and the heterogeneity of program participant backgrounds. Practically, these findings provide an overview that can be adopted by other educational institutions to improve students' Arabic language skills through comprehensive planning, collaborative implementation, and systematic evaluation.
Implementasi Aws Cloud Computing dan Devops pada Infrastruktur Aplikasi Monitoring Linux Server
Authors: Orlando Eriek , Chandra Yudi Irawan 
Published: August 2024

Penelitian ini bertujuan mengoptimalkan infrastruktur aplikasi monitoring Linux server di cloud computing menggunakan AWS dan Terraform. Infrastruktur tradisional seperti server baremetal memiliki biaya tinggi, sedangkan virtualisasi server dengan VMware mahal. Perusahaan-perusahaan IT perlu mengurangi biaya, meningkatkan efisiensi, dan memaksimalkan penggunaan server. AWS menawarkan layanan sewa server dengan prinsip pay as you go. Hashicorp menciptakan Terraform sebagai alat otomasi untuk membangun infrastruktur dan aplikasi di cloud computing. Terraform menjadi alat populer dalam dunia DevOps untuk mengotomatisasi proses deployment aplikasi di AWS, membantu tim mengelola infrastruktur dan aplikasi dengan efisien. Dengan memanfaatkan AWS Cloud Computing dan automasi dengan Terraform, solusi terbaik dapat tercapai.
De handelings(on)vrijheid van sociale partners: artikel 7:668a BW in het licht van clausule 8(4) Richtlijn 1999/70/EG
Authors: Ter Haar B.P. , Peters S.S.M. 
Published: August 2024

De handelings(on)vrijheid van sociale partners: artikel 7:668a BW in het licht van clausule 8(4) Richtlijn 1999/70/EG
In deze bijdrage betogen de auteurs dat de wijzigingen in de Nederlandse ketenregeling die de handelingsruimte van sociale partners steeds verder inperken, in strijd zijn met clausule 8(4) van Richtlijn 1999/70/EG betreffende contracten voor bepaalde tijd. In clausule 8(4) is een bijzondere rol toegekend aan sociale partners bij de tenuitvoerlegging van de richtlijn. In die rol kunnen sociale partners afwijkende maatregelen treffen waarmee wordt voorzien in specifieke behoeften. De rechter kan dergelijke maatregelen van sociale partners slechts marginaal toetsen en de wetgever kan zelf afwijkende maatregelen treffen, zolang er ruimte gelaten wordt voor nadere afwijkende maatregelen van sociale partners. Van sociale partners mag verwacht worden dat ze bij het treffen van dergelijke maatregelen in de geest van de richtlijn handelen en dit kenbaar gemotiveerd doen.
Beloning in het internationaal wegtransport: zwoegen met gezichtspunten
Authors: Even J.H. , Zwanenburg A. 
Published: August 2024

Beloning in het internationaal wegtransport: zwoegen met gezichtspunten
De procedures tegen transportbedrijf Van den Bosch en zijn buitenlandse zusterondernemingen met als inzet een Nederlands loon voor buitenlandse chauffeurs hebben inmiddels de hoogste nationale en Europese instanties bereikt. In deze bijdrage geven de auteurs de stand van zaken weer en plaatsen wij de procedures in het internationaal privaatrechtelijk kader.
COVID-19 Modified mRNA “Vaccines”: Lessons Learned from Clinical Trials, Mass Vaccination, and the Bio-Pharmaceutical Complex, Part 2
Authors: Mead M. Nathaniel , Seneff Stephanie , Rose Jessica , Wolfinger Russ , Hulscher Nicolas , McCullough Peter A. 
Published: August 2024

The COVID-19 modified mRNA (modmRNA) lipid nanoparticle-based “vaccines” are not classical antigen-based vaccines but instead prodrugs informed by gene therapy technology. Of considerable note, these products have been linked to atypical adverse and serious adverse event profiles. As discussed in Part 1, health-related risks and drawbacks were drastically misreported and underreported in the Pfizer and Moderna trial evaluations of these genetic products. Now in Part 2, we examine the main structural and functional aspects of these injectables. The COVID-19 modmRNA injectable products introduce a unique set of biological challenges to the human body with the potential to induce an extensive range of adverse, crippling, and life-threatening effects. Based on the fact that there is no current method to quantify host (cell-based) spike protein production in vivo following injection with these prodrugs, there is no standard “dose”. This is in part due to differences in spike protein production output, which depends on cell metabolism and transfection efficiency. It is therefore difficult to predict adverse event profiles on an individual basis, but considering that millions of adults across the world have reported severe and serious adverse events in the context of these modmRNA COVID-19 products, valid concerns are raised regarding injection of infants and younger age groups for whom COVID-19 poses only minimal risks. We address the process-related genetic impurities inherent in mass production of these products, and the potential risks posed by these contaminants. We then categorize the principal adverse events associated with the modmRNA products with a brief systems-based synopsis of each of the six domains of potential harms: (1) cardiovascular, (2) neurological, (3) hematologic; (4) immunological, (5) oncological, and (6) reproductive. We conclude with a discussion of the primary public health and regulatory issues arising from this evidence-informed synthesis of the literature and reiterate the urgency of imposing a global moratorium on the modmRNA-LNP-based platform.