bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trainee Therapists' Experiences of Supervision During Training: A Meta‐synthesis
Authors: Wilson Hannah M. N. , Davies Jenny S. , Weatherhead Stephen 
Published: April 2015

PurposeSupervision is typically mandatory for therapists in training and plays an important role in their professional development. A number of qualitative studies have considered specific aspects of supervision. This systematic review aimed to synthesize these studies' findings and explore the experience and impact of supervision for trainee therapists.MethodsA systematic search of the literature was conducted, and inclusion/exclusion criteria were applied. This led to a sample of 15 qualitative studies, with which a meta‐synthesis was conducted.ResultsThe meta‐synthesis led to four key concepts: supervision as a learning opportunity, the supervisory relationship, power in supervision and the impact of supervision. These themes explored helpful and unhelpful aspects of supervision, including some concerns regarding the evaluation of supervision.ConclusionsSupervision can effectively support trainee therapists in their personal and professional development. However, it can also lead to feelings of distress and self‐doubt. Supervisors need to consider the power differential within supervision and attend to different factors within the supervisory relationship. Copyright © 2015 John Wiley & Sons, Ltd.Key Practitioner Message

Supervision can encourage personal and professional development, but it can also have a detrimental impact on trainee therapists' well‐being, and consequently their clinical work and clients' experiences.
Supervisees may not disclose unhelpful events or impacts from supervision, for fear of negative evaluation.
Evaluation of supervisors should be facilitated and encouraged, to maintain good practice.
Detection of small abnormal B‐Lymphoblast populations at diagnosis of chronic myelogenous leukemia, BCR‐ABL1+: Incidence, phenotypic features, and clinical implications
Authors: Vrotsos Elena , Gorgan Maria , DiGiuseppe Joseph A. 
Published: April 2015

BackgroundAccording to the 2008 World Health Organization (WHO) Classification of Tumors of the Haematopoietic and Lymphoid Tissues, the finding of B lymphoblasts in the blood or bone marrow of a patient with chronic myelogenous leukemia, BCR‐ABL1+ (CML) should raise a concern for progression of the disease to B‐lymphoblastic blast phase. Data addressing the incidence and phenotypic features of abnormal B lymphoblasts in CML, and whether the detection of B lymphoblasts inexorably heralds blast phase in CML, though, are limited.MethodsWe reviewed a consecutive series of patients with newly diagnosed CML who had undergone bone marrow examination with flow cytometric immunophenotyping. Polychromatic immunophenotyping data were reviewed, and clinical follow‐up data were obtained.ResultsA precursor B‐cell population with an abnormal composite immunophenotype was detected in 4 of 36 (11.1%) diagnostic bone marrow samples, at levels ranging from 0.01% to 0.30% of viable single cells acquired. The most common phenotypic aberrations were abnormally bright expression of CD10 and CD19 (seen in four and three cases, respectively), and abnormally dim expression of CD38 (seen in four cases). All three patients with adequate clinical follow‐up have achieved and maintained a deep or major molecular response with a tyrosine kinase inhibitor, and none has progressed to B‐lymphoblastic blast phase (follow‐up duration: 17–46 months).ConclusionsIn chronic‐phase CML, a small (<0.5%) abnormal B‐lymphoblast population is present in a significant minority of diagnostic bone marrow samples, but does not inevitably herald progression to B‐lymphoblastic blast phase. © 2015 International Clinical Cytometry Society
Prognostic role of cardiac power index in ambulatory patients with advanced heart failure
Authors: Grodin Justin L. , Mullens Wilfried , Dupont Matthias , Wu Yuping , Taylor David O. , Starling Randall C. , Tang W. H. Wilson 
Published: April 2015

BackgroundCardiac pump function is often quantified by left ventricular ejection fraction by various imaging modalities. As the heart is commonly conceptualized as a hydraulic pump, cardiac power describes the hydraulic function of the heart. We aim to describe the prognostic value of resting cardiac power index (CPI) in ambulatory patients with advanced heart failure.Methods and resultsWe calculated CPI in 495 sequential ambulatory patients with advanced heart failure who underwent invasive haemodynamic assessment with longitudinal follow‐up of adverse outcomes (all‐cause mortality, cardiac transplantation, or ventricular assist device placement). The median CPI was 0.44 W/m2 (interquartile range 0.37, 0.52). Over a median of 3.3 years, there were 117 deaths, 104 transplants, and 20 ventricular assist device placements in our cohort. Diminished CPI (<0.44 W/m2) was associated with increased adverse outcomes [hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.8–3.1, P < 0.0001). The prognostic value of CPI remained significant after adjustment for age, gender, pulmonary capillary wedge pressure, cardiac index, pulmonary vascular resistance, left ventricular ejection fraction, and creatinine [HR 1.5, 95% CI 1.03–2.3, P = 0.04). Furthermore, CPI can risk stratify independently of peak oxygen consumption (HR 2.2, 95% CI 1.4–3.4, P = 0.0003).ConclusionResting cardiac power index provides independent and incremental prediction in adverse outcomes beyond traditional haemodynamic and cardio‐renal risk factors.
Dioxomolybdenum(VI) and ‐tungsten(VI) Complexes with Multidentate Aminobisphenol Ligands as Catalysts for Olefin Epoxidation
Authors: Dupé Antoine , Hossain Md. Kamal , Schachner Jörg A. , Belaj Ferdinand , Lehtonen Ari , Nordlander Ebbe , Mösch‐Zanetti Nadia C. 
Published: April 2015

AbstractThe synthesis of four molybdenum and tungsten complexes bearing tetradentate tripodal amino bisphenolate ligands with either hydroxyethylene (1a) or hydroxyglycolene (1b) substituents is reported. The molybdenum dioxo complexes [MoO2L] (L = 2a, 2b) and tungsten complexes [WO2L] (3a, 3b) were synthesized using [MoO2(acac)2] and [W(eg)3] (eg = 1,2‐ethanediolato, ethylene glycolate), respectively, as precursors. All complexes were characterized by spectroscopic means as well as by single‐crystal X‐ray diffraction analyses. The latter reveal, in all cases, hexacoordinate complexes in which the hydrogen atom of the hydroxy group is involved in hydrogen bonding with one of the metal oxo groups. In the case of the glycol substituent, the ether oxygen atom is coordinated to the metal whereas the hydroxy group remains uncoordinated. The complexes were tested as catalysts in the epoxidation of cyclooctene under eco‐friendly conditions, using an aqueous solution of H2O2 as the oxidant and dimethyl carbonate (DMC) as solvent or neat conditions, as substitutes for chlorinated solvents. Molybdenum complexes 2a and 2b showed good catalytic activity using H2O2 without added solvent, and tungsten complexes 3a and 3b showed very high activity in the epoxidation of cyclooctene using H2O2 and DMC as solvents.
Bis(phosphinimino)amide Supported Borondihydride and Heteroleptic Dihalo Compounds of Group 13
Authors: Jaiswal Kuldeep , Prashanth Billa , Bawari Deependra , Singh Sanjay 
Published: April 2015

AbstractThe reaction of tetraphenyldiphosphazane (Ph2P)2NH with mesityl azide 2,4,6‐Me3C6H2‐N3 affords a new [N,N′] chelating ligand, [HN(Ph2PN(2,4,6‐Me3C6H2))2] (LH). The ligand can be easily deprotonated by using nBuLi or Li[N(SiMe3)2] in Et2O to yield [{N(Ph2PN(2,4,6‐Me3C6H2))2}Li·OEt2] (1). The reaction of LH with AlMe3 and BH3·SMe2, respectively, gives the corresponding mononuclear complexes [{N(Ph2PN(2,4,6‐Me3C6H2))2}AlMe2] (2) and a rare borondihydride [{N(Ph2PN(2,4,6‐Me3C6H2))2}BH2] (3). Similarly, reaction of 1 with the trihalides, MX3, of group 13 elements afford the corresponding dihalo complexes, [{N(Ph2PN(2,4,6‐Me3C6H2))2}MX2] [M = B, X = F (4); M = Al, X = Cl (5); M = Ga, X = Cl (6); M = In, X = Br (7)]. All the complexes reported in this work have been isolated in good yields and are expected to serve as useful synthons in a number of reactions. The solid‐state structure of LH and 1–7 have been investigated by single‐crystal X‐ray structural analysis.
Pd/Pivalic Acid Mediated Direct Arylation of 2‐Pyrones and Related Heterocycles
Authors: Pardo Leticia M. , Prendergast Aisling M. , Nolan Marie‐T. , Ó Muimhneacháin Eoin , McGlacken Gerard P. 
Published: April 2015

AbstractDirect arylation represents a favourable alternative to traditional cross‐coupling reactions and has found widespread use with simple aryls and robust heterocycles. Herein a direct arylation protocol has been optimised and applied to more delicate, privileged biological motifs. The intramolecular direct arylation of 2‐pyrones, 2‐coumarins, 2‐pyridones and 2‐quinolones occurs in very good to excellent yields using a Pd0 source and pivalic acid as a crucial additive. Preliminary mechanistic investigations were also carried out.
Performance analysis of space modulation techniques over α − μ and κ − μ fading channels with imperfect channel estimation
Authors: Badarneh Osamah S. , Mesleh Raed 
Published: April 2015

AbstractIn this paper, the performance analysis of spatial modulation and space shift keying multiple‐input multiple‐output techniques over generalised α − μ and κ − μ fading channels with imperfect channel state information at the receiver is presented. In particular, the pair‐wise error probability (PEP) of the systems under study is derived. The PEP expression jointly considers the envelope and the phase distributions of the fading channels. The obtained PEP is then used to derive an upper bound closed‐form expression for the average bit error rate. The influence of the fading parameters (i.e. α,κ and μ) and the channel estimation error on the system performance are analysed and discussed through representative numerical examples. The correctness of the conducted analysis is validated by means of Monte‐Carlo simulations. Copyright © 2015 John Wiley & Sons, Ltd.
Development of lysozyme‐combined antibacterial system to reduce sulfur dioxide and to stabilizeItalianRiesling ice wine during aging process
Authors: Chen Kai , Han Shun‐yu , Zhang Bo , Li Min , Sheng Wen‐jun 
Published: April 2015

AbstractFor the purpose ofSO2reduction and stabilizing ice wine, a new antibacterial technique was developed and verified in order to reduce the content of sulfur dioxide (SO2) and simultaneously maintain protein stability during ice wine aging process. Hazardous bacterial strain (lactic acid bacteria,LAB) and protein stability of Italian Riesling ice wine were evaluated in terms of different amounts of lysozyme,SO2, polyphenols, and winepHby single‐factor experiments. Subsequently, a quadratic rotation‐orthogonal composite design with four variables was conducted to establish the multiple linear regression model that demonstrated the influence of different treatments on synthesis score betweenLABinhibition and protein stability of ice wine. The results showed that, synthesis score can be influenced by lysozyme andSO2concentrations on an extremely significant level (P < 0.01). Furthermore, the lysozyme‐combined antibacterial system, which is specially designed for ice wine aging, was optimized step by step by response surface methodology and ridge analysis. As a result, the optimal proportion should be control in ice wine as follows: 179.31 mg L−1lysozyme, 177.14 mg L−1SO2, 0.60 g L−1polyphenols, and 4.01 ice winepH. Based on this system, the normalized synthesis score betweenLABinhibition and protein stability can reach the highest point 0.920. Finally, by the experiments of verification and comparison, it was indicated that lysozyme‐combined antibacterial system, which was a practical and prospective method to reduceSO2concentration and effectively prevent contamination from hazardousLAB, can be used to stabilize ice wine during aging process.
A Behavioral Economic Model of Alcohol Advertising and Price
Authors: Saffer Henry , Dave Dhaval , Grossman Michael 
Published: April 2015

SummaryThis paper presents a new empirical study of the effects of televised alcohol advertising and alcohol price on alcohol consumption. A novel feature of this study is that the empirical work is guided by insights from behavioral economic theory. Unlike the theory used in most prior studies, this theory predicts that restriction on alcohol advertising on TV would be more effective in reducing consumption for individuals with high consumption levels but less effective for individuals with low consumption levels. The estimation work employs data from the National Longitudinal Survey of Youth, and the empirical model is estimated with quantile regressions. The results show that advertising has a small positive effect on consumption and that this effect is relatively larger at high consumption levels. The continuing importance of alcohol taxes is also supported. Education is employed as a proxy for self‐regulation, and the results are consistent with this assumption. The key conclusion is that restrictions on alcohol advertising on TV would have a small negative effect on drinking, and this effect would be larger for heavy drinkers. Copyright © 2015 John Wiley & Sons, Ltd.
How Business Cycles Affect the Healthcare Sector: A Cross‐country Investigation
Authors: Cleeren Kathleen , Lamey Lien , Meyer Jan‐Hinrich , De Ruyter Ko 
Published: April 2015

AbstractThe long‐term relationship between the general economy and healthcare expenditures has been extensively researched, to explain differences in healthcare spending between countries, but the midterm (i.e., business cycle) perspective has been overlooked. This study explores business cycle sensitivity in both public and private parts of the healthcare sector across 32 countries. Responses to the business cycle vary notably, both across spending sources and across countries. Whereas in some countries, consumers and/or governments cut back, in others, private and/or public healthcare buyers tend to spend more. We also assess long‐term consequences of business cycle sensitivity and show that public cost cutting during economic downturns deflates the mortality rates, whereas private cut backs increase the long‐term growth in total healthcare expenditures. Finally, multiple factors help explain variability in cyclical sensitivity. Private cost cuts during economic downturns are smaller in countries with a predominantly publicly funded healthcare system and more preventive public activities. Public cut backs during contractions are smaller in countries that rely more on tax‐based resources rather than social health insurances. Copyright © 2015 John Wiley & Sons, Ltd.
Follicular dendritic cell sarcoma of the head and neck: Case report, literature review, and pooled analysis of 97 cases
Authors: Pang John , Mydlarz Wojciech K. , Gooi Zhen , Waters Kevin M. , Bishop Justin , Sciubba James J. , Kim Young J. , Fakhry Carole 
Published: April 2015

AbstractBackgroundFollicular dendritic cell sarcoma (FDCS) is a rare lymphoid neoplasm presenting in the head and neck. There are no pooled analyses of head and neck FDCS cases in the English language literature.MethodsA MEDLINE and PubMed review of cases from 1978 to February 2014 was performed. Demographics, clinicopathologic data, and outcomes were summarized.ResultsWe presented 2 patients and analyzed 97 cases. The mean age was 42.7 years (SD = 16.3 years). Outcomes were available for 76 patients. Tumors ≤4 cm had better disease‐free survival (63% vs 28% at 5 years; p = .0282). Locoregional recurrence was significantly less likely with surgery and radiation compared to surgery alone (15% vs 45%; p = .019) and in patients receiving a neck dissection (10% vs 43%; p = .046).ConclusionThis pooled analysis provides the largest sample size of FDCS of the head and neck to date and suggests that radiation and neck dissection may be beneficial to locoregional oncologic control. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2241–E2249, 2016
Irrigation Water Management in a Mediterranean Greenhouse District: Irrigation Adequacy Assessment
Authors: Sánchez José A. , Reca Juan , Martínez Juan 
Published: April 2015

AbstractThe sustainability of greenhouse production in semi‐arid regions in the Mediterranean basin depends on the availability of water resources. However, the increasing demand for water has caused environmental and water availability concerns. The main objective of this work is to assess irrigation adequacy in an irrigation district located in southern Spain with major water resource problems in terms of both quantity and quality.Two resolution levels were considered: crop and farm. Relative irrigation supply (RIS) index was calculated for a wide sample of crops and farms in the area over the course of four consecutive agricultural seasons.An overall RIS value of 1.12 was obtained. This value indicates that irrigation water exceeded net irrigation needs and, consequently, moderate leaching fractions were applied. However, a high RIS variability was observed. The effect of several factors was statistically analysed to explain this variability.The average water supply to farms was slightly higher than that applied in similar greenhouse districts, possibly due to higher irrigation water salinity. The high variability in the annual relative water supply (ARIS) to the farms confirmed that the main source of variability was farmer management decisions. Irrigation performance in this area could be improved with a proper extension of good irrigation practices. Copyright © 2015 John Wiley & Sons, Ltd.
The Effect of Fragmentation in Trading on Market Quality in the UK Equity Market
Authors: Boneva Lena , Linton Oliver , Vogt Michael 
Published: April 2015

SummaryWe investigate the effects of fragmentation in equity markets on the quality of trading outcomes in a panel of FTSE stocks over the period 2008–2011. This period coincided with a great deal of turbulence in the UK equity markets, which had multiple causes that need to be controlled for. To achieve this, we use the common correlated effects estimator for large heterogeneous panels. We extend this estimator to quantile regression to analyse the whole conditional distribution of market quality. We find that both fragmentation in visible order books and dark trading that is offered outside the visible order book lower volatility. But dark trading increases the variability of volatility, while visible fragmentation has the opposite effect, in particular at the upper quantiles of the conditional distribution. The transition from a monopolistic to a fragmented market is non‐monotonic with respect to the degree of fragmentation. Copyright © 2015 John Wiley & Sons, Ltd.
Effect of combined treatment with immunoadsorption and membrane filtration on plasma coagulation—Results of a randomized controlled crossover study
Authors: Biesenbach Peter , Eskandary Farsad , Ay Cihan , Wiegele Marion , Derfler Kurt , Schaden Eva , Haslacher Helmuth , Oberbauer Rainer , Böhmig Georg A. 
Published: April 2015

The combined use of immunoadsorption (IA) and membrane filtration (MF) may markedly enhance removal of IgM and complement component C1q, supporting its use as an element of recipient desensitization in antibody‐incompatible transplantation. However, coagulation factor removal may contribute to altered hemostasis, posing a risk of bleeding in the perioperative setting. This secondary endpoint analysis of standard coagulation assays and rotational thromboelastometry (ROTEM®) was performed in the context of a randomized controlled crossover study designed to assess the effect of combined IA (GAM‐146‐peptide) and MF on levels of ABO antigen‐specific IgM. Fourteen patients with autoimmune disorders were randomized to a single treatment with IA+MF followed by IA alone, or vice versa. MF was found to markedly enhance fibrinogen depletion (57% vs. 28% median decrease after IA alone, P < 0.001), whereby four patients showed post‐treatment fibrinogen concentrations below 100 mg dL−1. In support of a critical contribution of fibrinogen depletion to impaired coagulation, extrinsically activated ROTEM® analysis revealed a marked reduction in fibrinogen‐dependent clot formation upon IA+MF (59% median decrease in FIBTEM mean clot firmness (MCF) as compared to 24% after IA alone, P < 0.001). Moreover, the addition of MF led to a substantial prolongation of activated partial thromboplastin time, possibly due to depletion of macromolecular coagulation factors contributing to intrinsically activated coagulation. Our study demonstrates substantial effects of combined IA+MF on clot formation, which may be mainly attributable to fibrinogen depletion. We suggest that the use of combined apheresis in the setting of transplant surgery may necessitate a careful monitoring of coagulation. J. Clin. Apheresis 31:29–37, 2016. © 2015 Wiley Periodicals, Inc.
Nitric Oxide Mediates Bleomycin‐induced Angiogenesis and Pulmonary Fibrosis via Regulation of VEGF
Authors: Iyer Anand Krishnan V. , Ramesh Vani , Castro Carlos A. , Kaushik Vivek , Kulkarni Yogesh M. , Wright Clayton A. , Venkatadri Rajkumar , Rojanasakul Yon , Azad Neelam 
Published: April 2015

ABSTRACTPulmonary fibrosis is a progressive lung disease hallmarked by increased fibroblast proliferation, amplified levels of extracellular matrix deposition and increased angiogenesis. Although dysregulation of angiogenic mediators has been implicated in pulmonary fibrosis, the specific rate‐limiting angiogenic markers involved and their role in the progression of pulmonary fibrosis remains unclear. We demonstrate that bleomycin treatment induces angiogenesis, and inhibition of the central angiogenic mediator VEGF using anti‐VEGF antibody CBO‐P11 significantly attenuates bleomycin‐induced pulmonary fibrosis in vivo. Bleomycin‐induced nitric oxide (NO) was observed to be the key upstream regulator of VEGF via the PI3k/Akt pathway. VEGF regulated other important angiogenic proteins including PAI‐1 and IL‐8 in response to bleomycin exposure. Inhibition of NO and VEGF activity significantly mitigated bleomycin‐induced angiogenic and fibrogenic responses. NO and VEGF are key mediators of bleomycin‐induced pulmonary fibrosis, and could serve as important targets against this debilitating disease. Overall, our data suggests an important role for angiogenic mediators in the pathogenesis of bleomycin‐induced pulmonary fibrosis. J. Cell. Biochem. 116: 2484–2493, 2015. © 2015 Wiley Periodicals, Inc.