bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating drug withdrawal syndrome risks through food and drug administration adverse event reporting system: a comprehensive disproportionality analysis
Authors: Zhang Zheng , Yang Qianzhi , Chen Minghao , Yang Wah , Wang Yuping 
Published: July 2024

ObjectiveThe study aims to identify the drugs associated with drug withdrawal syndrome in the Food and Drug Administration Adverse Event Reporting System (FAERS) and estimate their risks of causing withdrawal syndrome.MethodsAll the data were collected from FAERS from the first quarter of 2004 to the third quarter of 2023. Disproportionality analyses of odds ratio (ROR) and proportional reported ratio were conducted to identify potential adverse effects signal of drug withdrawal syndrome.ResultsA total of 94,370 reports related to withdrawal syndrome from the data. The top 50 drugs with most frequency reported were analyzed, and 29 exhibited a positive signal based on the number of reports. The top three categories of drugs with positive signals included opioids, antidepressant drugs and antianxiety drugs. Other classifications included opioid antagonist, muscle relaxant, antiepileptic drugs, analgesics, hypnotic sedative drugs and antipsychotic drugs.ConclusionOur analysis of FAERS data yielded a comprehensive list of drugs associated with withdrawal syndrome. This information is vital for healthcare professionals, including doctors and pharmacists, as it aids in better recognition and management of withdrawal symptoms in patients undergoing treatment with these medications.
Hypoxia-inducible factor-prolyl hydroxylase inhibitors for treatment of anemia in chronic kidney disease: a systematic review and network meta-analysis
Authors: Ren Song , Zhao Yurong , Wu Jingyu , Ren Shangqing , Feng Yunlin 
Published: July 2024

PurposeTo review current evidence on the efficacy and safety outcomes of HIF-PHIs in chronic kidney disease (CKD) populations with an emphasize on the safety profile.MethodsA systematic search was conducted in the Medline, Embase, and Cochrane Central databases. Randomized controlled trials that had assessed the efficacy and safety of HIF-PHIs for anemia in CKD were included. The efficacy outcome included change of hemoglobin and the safety outcomes any adverse events, severe adverse events, major adverse cardiovascular events, and mortality. The qualities of studies were assessed using the Cochrane ROB tool.Results47 studies encompassing 55 RCTs for the study outcomes were included in this study. All six commercially available HIF-PHIs had direct comparisons to ESA and placebo, yet lacked direct comparisons among each other. The network analysis demonstrated all six HIF-PHIs were able to effectively elevate hemoglobin in the general CKD patients compared to placebo. All HIF-PHIs did not differ among each other in the efficacy of correcting anemia. Roxadustat and daprodustat had the largest number of reports in terms of adverse events. The overall risk of each safety outcome did not increase in comparison to erythropoiesis stimulating agent (ESA) or placebo, and did not differ among different types of HIF-PHIs.ConclusionHIF-PHIs can effectively elevate hemoglobin without causing higher risk of safety concerns in CKD patients with anemia. Further evidence from long-term studies and the ongoing post-market surveillance is necessary.
Bacillus velezensis HN-2: a potent antiviral agent against pepper veinal mottle virus
Authors: Xuan Zhe , Wang Yu , Shen Yuying , Pan Xiao , Wang Jiatong , Liu Wenbo , Miao Weiguo , Jin Pengfei 
Published: July 2024

BackgroundPepper veinal mottle virus (PVMV) belongs to the genus Potyvirus within the family Potyviridae and is a major threat to pepper production, causing reduction in yield and fruit quality; however, efficient pesticides and chemical treatments for plant protection against viral infections are lacking. Hence, there is a critical need to discover highly active and environment-friendly antiviral agents derived from natural sources. Bacillus spp. are widely utilized as biocontrol agents to manage fungal, bacterial, and viral plant diseases. Particularly, Bacillus velezensis HN-2 exhibits a strong antibiotic activity against plant pathogens and can also induce plant resistance.MethodsThe experimental subjects employed in this study were Bacillus velezensis HN-2, benzothiadiazole, and dufulin, aiming to evaluate their impact on antioxidant activity, levels of reactive oxygen species, activity of defense enzymes, and expression of defense-related genes in Nicotiana benthamiana. Furthermore, the colonization ability of Bacillus velezensis HN-2 in Capsicum chinense was investigated. ResultsThe results of bioassays revealed the robust colonization capability of Bacillus velezensis HN-2, particularly in intercellular spaces, leading to delayed infection and enhanced protection against PVMV through multiple plant defense mechanisms, thereby promoting plant growth. Furthermore, Bacillus velezensis HN-2 increased the activities of antioxidant enzymes, thereby mitigating the PVMV-induced ROS production in Nicotiana benthamiana. Moreover, the application of Bacillus velezensis HN-2 at 5 dpi significantly increased the expression of JA-responsive genes, whereas the expression of salicylic acid-responsive genes remained unchanged, implying the activation of the JA signaling pathway as a crucial mechanism underlying Bacillus velezensis HN-2-induced anti-PVMV activity. Immunoblot analysis revealed that HN-2 treatment delayed PVMV infection at 15 dpi, further highlighting its role in inducing plant resistance and promoting growth and development. ConclusionsThese findings underscore the potential of Bacillus velezensis HN-2 for field application in managing viral plant diseases effectively.
Physical activity and recreational screen time among Chinese children and adolescents: a national cross-sectional study
Authors: Guo Mingming , Zhu Yangming , Wang Xiaozan 
Published: July 2024

BackgroundThe increasing prevalence of physical inactivity and prolonged Recreational Screen Time (RST) among children and adolescents is emerging as a significant public health concern. This study investigates the current status of Physical Activity (PA) and RST among Chinese children and adolescents from 2017 to 2019. It also examines variations in PA and RST across different school levels, genders, urban–rural areas, regions, and seasons.MethodsA national cross-sectional survey, conducted in China from 2017 to 2019, included 53,101 children and adolescents from grades 4 to 12 (aged 10 to 18 years old). Data on PA and RST were collected via self-administered questionnaires. The study employed descriptive statistics, calculated weighted prevalence rates, and conducted differential analysis across diverse demographic groups.ResultsBetween 2017 and 2019 in China, merely 28.73% of children and adolescents adhered to World Health Organization’s PA guidelines, while 76.09% met China’s RST guidelines. Notably, females, higher-grade students, rural residents, and children and adolescents from southern regions exhibited significantly lower levels of PA compared to their male, lower-grade, urban, and northern counterparts. Concurrently, RST was significantly higher among males, lower-grade students, rural residents, and those from northern regions. Seasonal variations were also observed, with lower PA and higher RST in autumn and winter as compared to spring.ConclusionThe study reveals a concerning low level of PA among Chinese children and adolescents, with marked disparities in PA and RST across different groups. This underscores the need for targeted health promotion strategies to enhance PA and mitigate RST among various child and adolescent populations.
Implementing concepts from green logistics in the turkey production supply chain
Authors: Wilson Griffin , Horsey Bazyl , Stone Richard 
Published: July 2024

IntroductionThe global turkey market represents a sector of increasing growth in the previous decade, and projections for the next decade reflect the probable continuation of this growth. Industry trends also indicate the globalization of turkey meat production, as the loci of production has continually shifted from one dominated by the United States to one with an increasing number of production units globally. In contrast with other popular meat products, comparatively fewer resources have been devoted to academic research concerning the growth, production, distribution, and sale of turkey and turkey products. This lack of research is particularly notable in the area of supply chain management and environmental sustainability. Given the increasing volume of turkey production and lower volume of academic interest, it stands to reason that there remain many opportunities for improvement across the value chain in this industry.MethodsIn this paper, we take a “green logistics” approach and use data provided by one of the largest turkey producers in the United States to formulate a mixed-integer program aimed at minimizing the environmental impact of turkey products in a segment of the product supply chain.ResultsImplementation of the resulting brooder-finisher farm assignments developed by the model would yield an average 50% decrease (184 metric ton) in greenhouse gas emissions at the operation under investigation while also addressing other areas of significant vulnerability for the industry (production costs, biosecurity risk, and animal wellbeing).DiscussionAs consolidated turkey meat production systems continue to expand globally, we argue that a similar approach could readily be deployed by these growing and emerging production systems.
Development of multiplex real-time PCR for simultaneous detection of SARS-CoV-2, CCoV, and FIPV
Authors: Liu Yan , Zhu Zhen , Du Jige , Zhu Xiaojie , Pan Chenfan , Yin Chunsheng , Sun Weidong 
Published: July 2024

IntroductionCoronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), canine coronavirus (CCoV), and feline infectious peritonitis virus (FIPV), have the potential for interspecies transmission. These viruses can be present in complex environments where humans, dogs, and cats coexist, posing a significant threat to both human and animal safety.Methods and resultsIn this study, we developed a novel multiplex TaqMan-probe-based real-time PCR assay for the simultaneous detection and differentiation of SARS-CoV-2, CCoV, and FIPV. Specific primers and TaqMan fluorescent probes were designed based on the N region of SARS-CoV-2 and FIPV, as well as the S region of CCoV, which demonstrated a remarkable sensitivity and specificity toward the targeted viruses, as few as 21.83, 17.25 and 9.25 copies/μL for SARS-CoV-2, CCoV and FIPV, respectively. The standard curve constructed by the optimized method in our present study showed a high amplification efficiency within or near the optimal range of 91% to 116% and R(2) values were at least 0.95 for the abovementioned coronaviruses. A total of 91 samples, including six plasmid mixed mock samples, four virus fluid mixing simulated samples, and 81 clinical samples, were analyzed using this method. Results demonstrated strong agreement with conventional approaches.DiscussionBy enabling the simultaneous detection of three viruses, this method enhances testing efficiency while decreasing costs. Importantly, it provides a valuable tool for the prevalence and geographical distribution of suspected and co-infected animals, ultimately contributing to the advancement of both animal and public health.
Climate Disaster and Cognitive Ability: Evidence From Wildfire
Authors: Du Ran , Liu Ke , Zhao Dangru , Fang Qiyun 
Published: July 2024

ObjectivesWe investigate the impact of wildfire disasters on cognitive health (i.e., thinking and language skills) in individuals aged 10 years and older using 2014 and 2018 wildfire and cognitive ability survey data from China.MethodsWe distinguished wildfires in each county at different wind directions each day by exogenous wind direction changes, and analyzed the effects of wildfires on cognitive abilities through upwind and non-upwind wildfires.ResultsOur analysis shows that for every 10-unit increase in upwind wildfires compared to non-upwind wildfires, respondents’ scores on word and math tests decrease by 0.235 and 0.236 standard deviations, respectively. Furthermore, we find that the impact of wildfire on cognitive ability is more pronounced in younger individuals, and those with lower defensive expenditures experience more severe impacts. Additionally, wildfires negatively affect individuals’ cognitive abilities by generating air pollution.ConclusionWildfires significantly reduce individuals’ cognitive abilities. Two recommendations are as follows: 1) governments should follow the principle of green development, introduce relevant regulations, and increase investment in adaptive technologies. 2) Individuals should raise awareness of climate hazards preparedness and strengthen defensive protection.
From prenatal diagnosis to surgical treatment: two case reports of congenital granular cell epulis
Authors: Han Yibing , Qiu Wen , Zhang Yu , Hua Mengmeng , Liu Shaohua , Dong Zuoqing 
Published: July 2024

Herein, we detail a multidisciplinary approach and sequential treatment for two infants with congenital granular cell epulis (CGCE). Ultrasonic examinations at 34 weeks of gestation revealed prominent oral masses in both fetuses. To devise a carefully considered treatment strategy, a comprehensive multidisciplinary consultation including oral and maxillofacial surgeons, pediatricians, obstetricians, and anesthesiologists was convened. Following cesarean sections, the lesions were successfully removed, measuring approximately 30 × 15 mm and 30 × 20 mm in size, respectively. Immunohistochemical analysis showed that vimentin was positive, S-100 protein was negative, and NSE protein and CD68 protein were negative. These findings underscore the importance of prenatal diagnosis of congenital granular cell epulis for the effective management of these rare benign conditions.
EFEKTIVITAS MEDIA FINGERPRINT TERHADAP PENINGKATAN DISIPLIN KARYAWAN PADA YAYASAN AL-FATH BEKASI
Authors: Budi Tarwanto Irwan 
Published: July 2024

Penelitian ini mengkaji tentang penerapan media fingerprint terhadap peningkatan disiplin karyawan pada sebuah instansi, dengan tujuan memberikan peningkatan produktivitas karyawan terhadap instansi yang berawal dari kedisiplinan atas kehadiran karyawan di tempat kerja sehingga membantu instansi agar terus berkembang. Penulisan Laporan penelitian ini disajikan secara deskriptif untuk memperoleh gambaran dan informasi yang jelas mengenai efektivitas media fingerprint terhadap peningkatan disiplin karyawan pada Yayasan Al-Fath Bekasi. Metode pengumpulan data yang dilakukan penulis yaitu dengan studi pustaka, studi lapangan yang terdiri dari wawancara, pengamatan (observasi) dan teknik dokumentasi. Kesimpulan yang dapat diambil bahwa penerapan fingerprint di Kantor Pengawasan dan Pelayanan Bea dan Cukai Tipe Madya Pabean Cikarang sudah cukup efektif dan berguna untuk memberikan informasi yang selengkap-lengkapnya kepada pimpinan yang berhubungan dengan kedisiplinan karyawan.
Targeted H
2
S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane
Authors: Liu Lin , Yao Yucen , Liu Yang , Hong Bingrong , Li Ziqing , Chen Xuejun , Zhang Yaofeng , Fu Hongbo , Yang Degong , Yang Chunrong 
Published: July 2024

Management of myocardial ischemia–reperfusion injury (MIRI) in reperfusion therapy remains a major obstacle in the field of cardiovascular disease, but current available therapies have not yet been achieved in mitigating myocardial injury due to the complex pathological mechanisms of MIRI. Exogenous delivery of hydrogen sulfide (H
2
S) to the injured myocardium can be an effective strategy for treating MIRI due to the multiple physiologic functions of H
2
S, including anti-inflammatory, anti-apoptotic, and mitochondrial protective effects. Here, to realize the precise delivery and release of H
2
S, we proposed the targeted H
2
S-mediated gas therapy with pH-sensitive release property mediated by platelet membranes (PMs). In this study, a biomimetic functional poly(lactic-co-ethanolic acid) nanoparticle (RAPA/JK-1-PLGA@PM) was fabricated by loading rapamycin (RAPA; mTOR inhibitor) and JK-1 (H
2
S donor) and then coated with PM. In vitro observations were conducted including pharmaceutical evaluation, H
2
S release behaviors, hemolysis analysis, serum stability, cellular uptake, cytotoxicity, inhibition of myocardial apoptosis, and anti-inflammation. In vivo examinations were performed including targeting ability, restoration of cardiac function, inhibition of pathological remodeling, and anti-inflammation. RAPA/JK-1-PLGA@PM was successfully prepared with good size distribution and stability. Utilizing the natural infarct-homing ability of PM, RAPA/JK-1-PLGA@PM could be effectively targeted to the damaged myocardium. RAPA/JK-1-PLGA@PM continuously released H
2
S triggered by inflammatory microenvironment, which could inhibit cardiomyocyte apoptosis, realize the transition of pro-inflammation, and alleviate myocardial injury demonstrated in hypoxia/reoxygenation myocardial cell in vitro. Precise delivery and release of H
2
S attenuated inflammatory response and cardiac damage, promoted cardiac repair, and ameliorated cardiac function proven in MIRI mouse model in vivo. This research outlined the novel nanoplatform that combined immunosuppressant agents and H
2
S donor with the pH-sensitive release property, offering a promising therapeutic for MIRI treatment that leveraged the synergistic effects of gas therapy.
Pendekatan Sintesis Narasi Sabat Tanah dan Tradisi Ma’pebulam serta Implementasinya Bagi Penanganan Krisis Ekologi Tanah dan Air
Authors: Jimmy Jimmy Sucipto 
Published: July 2024

From this research, it was found that ecological crises, especially soil and water, can be prevented by providing space for soil and water to "breathe or rest for a while" and interpreting the word rest with postulates of the consequences that can be caused. The Mamasan people understanding of the ma’pebulam tradition can be interpreted in a new understanding as God's way of playing the role of man in His care and resting His ecological creation through a mandate for humans as empowerment partners. From this research, it was found that ecological crisis that occurs to land and water can be prevented by providing an understanding that land and water must be given enough rest time for them to renew themselves, followed by a description of the consequences as a complement so that there is full attention to it. The ma’pebulam tradition emphasizes the importance of mystical matters that build community beliefs with consequences if they are not followed and the land sabbath as a 'commandment of God', followed by implications if it is not obeyed. The assertion of 'consequences' will allow space for mindfulness of the need for the land and water to 'breathe' or rest.
Penelitian ini bertujuan memberikan sumbangsi dalam menciptakan keadilan ekologi dalam hal penanganan krisis tanah dan air, serta memberikan pemahaman baru terhadap masyarakat Mamasa mengenai tradisi ma’ pebulam. Metode penelitian yang digunakan adalah model teologi kontekstual yakni sintesis yang diperkenalkan oleh Stephen B. Bevans. Metode ini dilakukan dengan cara, penyusunan kembali elemen-elemen, penekanan pada kesamaan, atau bahkan penciptaan kerangka kerja teologis yang baru yang mencangkup bagian yang didialogkan tersebut. Dari penelitian ini ditemukan bahwa Krisis ekologis yang terjadi terhadap tanah dan air dapat dicegah dengan memberikan pemahaman bahwa tanah dan air harus diberikan waktu istirahat yang cukup baginya untuk memperbaharui “diri” namun diikuti dengan pemaparan akibat yang ditimbulkan sebagai pelengkap agar ada perhatian penuh terhadap hal tersebut. Tradisi ma’pebulam menegaskan betapa pentingnya hal-hal mistik yang membangun kepercayaan masyarakat dengan akibat jika tidak mengikutinya serta sabat tanah sebagai perintah Tuhan, yang juga diikuti akibat Ketika hal itu tidak dipatuhi. Penyataan akibat akan memberikan ruang untuk perhatian penuh bagi perlunya tanah dan air “bernapas sejenak” atau beristirahat.
Ethical Empowerment: Integrating Malay Local Wisdom with VCT to Fortify Students' Moral Character in History Learning
Authors: Bunari Bunari , Fikri Asyrul , Zakaria Nurhijrah Binti , Mkumbachi Ramadhani Lausi 
Published: July 2024

As juvenile delinquency rates rise in Indonesia, addressing the underlying moral degradation among adolescents becomes crucial. This study investigates the integration of Tanjak Melayu's local wisdom with Value Clarification Technique (VCT) in history education as a strategy for moral character enhancement in students. Using a qualitative ethnographic approach, data was collected through observation, interviews, document reviews, and validity tests, with data analysis performed via triangulation. The study identifies key values of Tanjak Melayu—dignity, politeness, and attractiveness—that can be effectively incorporated into history lessons using VCT. This integration shows a positive impact on student's moral character, providing not only knowledge but also facilitating practical learning tasks. The incorporation of Tanjak Melayu values into educational settings via VCT not only preserves cultural heritage but also actively promotes moral virtues among students. The findings suggest that VCT can be a dynamic tool in moral education, enhancing student engagement and ethical development. This study underscores the potential of culturally integrated education technologies in addressing adolescent behavioral issues. By embedding local cultural values into the curriculum, educational institutions can play a pivotal role in shaping the moral landscape of the next generation. This approach offers a scalable model for similar interventions across diverse educational contexts, aiming to curb juvenile delinquency through enhanced character education. The successful integration of Tanjak Melayu values into history education via VCT demonstrates a viable path towards improving the moral character of students, suggesting that similar cultural and technological adaptations in educational curricula could be beneficial on a broader scale.
Integration of AI Chatbots in Islamic Religious Education: Potential and Challenges from a Doctoral Student Perspective
Authors: Sholeh Mohammad , Rusydiyah Evi Fatimatur , Abu Bakar M. Yunus 
Published: July 2024

This article examines the application of artificial intelligence (AI), particularly chatbot technology such as ChatGPT, in higher education, with a specific focus on Islamic religious learning. The study involved 27 doctoral students from Sunan Ampel State Islamic University, Surabaya, using a survey method to explore their perceptions of ChatGPT in Islamic religious learning. Data was obtained via Google Forms using purposive and convenience sampling techniques. The survey contains 28 questions covering various aspects of ChatGPT's uses, benefits, limitations, and ethical issues. Data analysis using SPSS software, including frequency analysis, mean, and reliability. The results show a high level of reliability and reveal that using ChatGPT can improve productivity, learning quality, and personalization. However, there are limitations such as a lack of context understanding, limited personalization capabilities, and the potential to hinder human-to-human interactions. In addition, students also raised concerns about ethical issues such as plagiarism, assessment fairness, data privacy, dependency, and information bias. This article provides insights into the use of ChatGPT in higher education and emphasises the importance of considering ethical aspects in its implementation. To mitigate the ethical risks that may arise from the use of ChatGPT in educational settings, it is recommended that institutions develop policies, provide education, and ensure the availability of adequate resources. The article also emphasises the need for ethical risk mitigation measures associated with the use of ChatGPT in the educational environment.