bluuebunny/crossref_metadata_2025_split huggingface dataset:
Printable Magnetoelectronics
Authors: Makarov Denys , Karnaushenko Daniil , Schmidt Oliver G. 
Published: April 2013

AbstractThe field of printable electronics is well developed. A large variety of electronic components assembled as printable optoelectronic devices and communication modules are already available. However, the element responding to a magnetic field, which is highly demanded for the concept of printable electronics has only been realized very recently. A printable magnetic sensing device has been one of the remaining missing building blocks crucial to realize the concept of entirely printable electronics. Here, we position the novel topic of printable magnetic sensorics in a family of printable electronics and highlight possible application directions of this technology.
Oriented orthorhombic Lead Oxide film grown by vapour phase deposition for X‐ray detector applications
Authors: Benassi G. , Zambelli N. , Villani M. , Calestani D. , Pavesi M. , Zappettini A. , Zanotti L. , Paorici C. 
Published: April 2013

AbstractSeveral materials are under investigations for flat panel x‐ray detector applications. Among them, PbO shows interesting properties, i.e. high sensitivity, large stopping power and high resistivity at room temperature. However, the exploitation of PbO is limited by the difficulty to obtain good quality films constituted by a single phase. In this paper, we describe a new approach for the vapour phase growth of orthorhombic PbO films. The grown layers show a single phase, good crystallinity, and preferential orientation along the c axis. Optical characterization evidenced the presence of a broad defect band. Gold contacted films showed very high electrical resistivity and appreciable response to X‐ray radiation.
One‐Pot Conversion of Sugar and Sugar Polyols to n‐Alkanes without CC Dissociation over the Ir‐ReOx/SiO2 Catalyst Combined with H‐ZSM‐5
Authors: Chen Kaiyou , Tamura Masazumi , Yuan Zhenle , Nakagawa Yoshinao , Tomishige Keiichi 
Published: April 2013

AbstractInvited for this month′s cover is the group of Keiichi Tomishige at Tohoku University, Sendai (Japan). The image shows how OH groups of biomass‐derived compounds such as sugar polyols are selectively cut off by hydrogenolysis over an Ir‐ReOx/SiO2 catalyst, similar to how the skin of a pineapple can be cut off by using a knife. Read the full text of the article at 10.1002/cssc.201200940
CHIC—an automated approach for the detection of dynamic variations in complex microbial communities
Authors: Koch Christin , Fetzer Ingo , Harms Hauke , Müller Susann 
Published: April 2013

AbstractAltering environmental conditions change structures of microbial communities. These effects have an impact on the single‐cell level and can be sensitively detected using community flow cytometry. However, although highly accurate, microbial monitoring campaigns are still rarely performed applying this technique. One reason is the limited access to pattern analysis approaches for the evaluation of microbial cytometric data. In this article, a new analyzing tool, Cytometric Histogram Image Comparison (CHIC), is presented, which realizes trend interpretation of variations in microbial community structures (i) without any previous definition of gates, by working (ii) person independent, and (iii) with low computational demand. Various factors influencing a sensitive determination of changes in community structures were tested. The sensitivity of this technique was found to discriminate down to 0.5% internal variation. The final protocol was exemplarily applied to a complex microbial community dataset, and correlations to experimental variation were successfully shown. © 2013 International Society for Advancement of Cytometry
High‐precision characterization of individual E. coli cell morphology by scanning flow cytometry
Authors: Konokhova Anastasiya I. , Gelash Andrey A. , Yurkin Maxim A. , Chernyshev Andrey V. , Maltsev Valeri P. 
Published: April 2013

AbstractWe demonstrate a flow‐cytometric method to measure length and diameter of single Escherichia coli cells with sub‐diffraction precision. The method is based on the original scanning flow cytometer that measures angle‐resolved light‐scattering patterns (LSPs) of individual particles. We modeled the shape of E. coli cells as a cylinder capped with hemispheres of the same radius, and simulated light scattering by the models using the discrete dipole approximation. We computed a database of the LSPs of individual bacteria in a wide range of model parameters and used it to solve the inverse light‐scattering problem by the nearest‐neighbor interpolation. The solution allows us to determine length and diameter of each individual bacterium, including uncertainties of these estimates. The developed method was tested on two strains of E. coli. The resulting precision of bacteria length and diameter measurements varied from 50 nm to 250 nm and from 5 nm to 25 nm, respectively. The measured distributions of samples over length and diameter were in good agreement with measurements performed by optical microscopy and literature data. The described approach can be applied for rapid morphological characterization of any rod‐shaped bacteria. © 2013 International Society for Advancement of Cytometry
Sparse least mean fourth algorithm for adaptive channel estimation in low signal‐to‐noise ratio region
Authors: Gui Guan , Adachi Fumiyuki 
Published: April 2013

SUMMARYBoth least mean square (LMS) and least mean fourth (LMF) are popular adaptive algorithms with application to adaptive channel estimation. Because the wireless channel vector is often sparse, sparse LMS‐based approaches have been proposed with different sparse penalties, for example, zero‐attracting LMS and Lp‐norm LMS. However, these proposed methods lead to suboptimal solutions in low signal‐to‐noise ratio (SNR) region, and the suboptimal solutions are caused by LMS‐based algorithms that are sensitive to the scaling of input signal and strong noise. Comparatively, LMF can achieve better solution in low SNR region. However, LMF cannot exploit the sparse information because the algorithm depends only on its adaptive updating error but neglects the inherent sparse channel structure. In this paper, we propose several sparse LMF algorithms with different sparse penalties to achieve better solution in low SNR region and take the advantage of channel sparsity at the same time. The contribution of this paper is briefly summarized as follows: (1) construct the cost functions of the LMF algorithm with different sparse penalties; (2) derive their lower bounds; and (3) provide experiment results to show the performance advantage of the propose method in low SNR region. Copyright © 2013 John Wiley & Sons, Ltd.
A consistent on‐line Bayesian procedure for detecting change points
Authors: Moreno Elías , Javier Girón F. , García–Ferrer Antonio 
Published: April 2013

Bayesian inference on the change points in a given sample is a statistical model selection problem that presents two main difficulties. The first one is the selection of a reasonable prior distribution over the set of models, the number of which depends exponentially on the sample size, and the second is the high computational burden involved even when Markov chain Monte Carlo methods are used.We consider normal linear sampling models for describing the data between consecutive change points, the hierarchical uniform prior over the set of models, intrinsic priors over their model parameters, and to discuss an on‐line Bayesian procedure that alleviates the computational burden for moderate or large sample sizes. Under wide conditions, this procedure is shown to be consistent. Illustrations on simulated and real data sets are given, including the analysis of the change points in the annual mean temperature in central England for the years 1659 to 2011. Copyright © 2013 John Wiley & Sons, Ltd.
DERIVING TIME DISCOUNTING CORRECTION FACTORS FOR TTO TARIFFS
Authors: Attema Arthur E. , Brouwer Werner B.F. 
Published: April 2013

ABSTRACTThe Time Trade‐off (TTO) method is a popular method for valuing health state utilities and is frequently used in economic evaluations. However, this method produces utilities that are distorted by several biases. One important bias entails the failure to incorporate time discounting. This paper aims to measure time discounting for health outcomes in a sample representative for the general population. In particular, we estimate TTO scores alongside time discounting in order to derive a set of correction factors that can be employed to correct raw TTO scores for the downward bias caused by time discounting. We find substantial positive correction factors, which are increasing with the severity of the health state. Furthermore, higher discounting is found when using more severe health states in the discounting elicitation task. More research is needed to further develop discount rate elicitation procedures and test their validity, especially in general public samples. Moreover, future research should investigate the correction of TTO values for other biases as well, such as loss aversion, and to develop a criterion to test the external validity of TTO scores. Copyright © 2013 John Wiley & Sons, Ltd.
Beyond feedback control: the interactive use of performance management systems. Implications for process innovation in Italian healthcare organizations
Authors: Demartini Chiara , Mella Piero 
Published: April 2013

SUMMARYThis paper shows how the use of performance management systems affects managers' perception of satisfaction, the effectiveness of the control system and the performance related to process innovation. An exploratory empirical research has been conducted on 85 managers operating in Italian healthcare organizations. Empirical findings put forward that the interactive—as opposed to diagnostic—use of performance management systems enhances managerial satisfaction with the control system and managerial perception of effectiveness. The present study then showed that it is not the control itself that is an obstacle to innovation in organizations in general (and in health organizations in particular) but the diagnostic use of the control mechanisms, which impedes the interaction between the control personnel and those subject to the control. Finally, this paper addresses managerial implications and further research avenues. Copyright © 2013 John Wiley & Sons, Ltd.
Heat and mass transfer effects on MHD flow of a couple‐stress fluid in a horizontal wavy channel with viscous dissipation and porous medium
Authors: Muthuraj R. , Srinivas S. , Selvi R.K. 
Published: April 2013

AbstractThis paper looks at heat and mass transfer effects on an unsteady MHD flow of a couple‐stress fluid in a horizontal wavy porous space with travelling thermal waves in the presence of a heat source and viscous dissipation. Initially the temperatures of the walls are maintained at different constant temperatures. The analytical expressions for velocity, temperature, and concentration field are obtained by the regular perturbation technique. The results are presented graphically for various values of emerging dimensionless parameters of the problem and are discussed to show interesting aspects of the solution. © 2013 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21040PACS: 44.15.+a, 44.30.+f, 44.27.nd, 47.50.Cd
Family and Cultural Predictors of Depression Among Samoan American Middle and High School Students
Authors: Yeh Christine J. , Borrero Noah E. , Tito Patsy 
Published: April 2013

This study investigated family intergenerational conflict and collective self‐esteem as predictors of depression in a sample of 128 Samoan middle and high school students. Simultaneous regression analyses revealed that each independent variable significantly contributed to an overall model that accounted for 13% of the variance in depression. Implications for counseling research and practice are discussed in terms of how schools may consider ways to promote these youth's cultural worth and positive family dynamics.Este estudio investigó el conflicto familiar intergeneracional y la autoestima colectiva como predictores de depresión en una muestra de 128 estudiantes samoanos de enseñanza media y secundaria. Los análisis simultáneos de regresión revelaron que cada variable independiente contribuyó de forma significativa a un modelo general que explicó un 13% de la varianza en depresión. Se discuten las implicaciones para la investigación y práctica de la consejería, en términos de cómo las escuelas pueden considerar formas de promover el valor cultural de estos jóvenes y una dinámica familiar positiva.
Degradation and antibacterial properties of magnesium alloys in artificial urine for potential resorbable ureteral stent applications
Authors: Lock Jaclyn Y. , Wyatt Eric , Upadhyayula Srigokul , Whall Andrew , Nuñez Vicente , Vullev Valentine I. , Liu Huinan 
Published: April 2013

AbstractThis article presents an investigation on the effectiveness of magnesium and its alloys as a novel class of antibacterial and biodegradable materials for ureteral stent applications. Magnesium is a lightweight and biodegradable metallic material with beneficial properties for use in medical devices. Ureteral stent is one such example of a medical device that is widely used to treat ureteral canal blockages clinically. The bacterial colony formation coupled with the encrustation on the stent surface from extended use often leads to clinical complications and contributes to the failure of indwelling medical devices. We demonstrated that magnesium alloys decreased Escherichia coli viability and reduced the colony forming units over a 3‐day incubation period in an artificial urine (AU) solution when compared with currently used commercial polyurethane stent. Moreover, the magnesium degradation resulted in alkaline pH and increased magnesium ion concentration in the AU solution. The antibacterial and degradation properties support the potential use of magnesium‐based materials for next‐generation ureteral stents. Further studies are needed for clinical translation of biodegradable metallic ureteral stents. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 781–792, 2014.
Synthesis of strong polycations with improved biological properties
Authors: Wytrwal Magdalena , Koczurkiewicz Paulina , Wójcik Kinga , Michalik Marta , Kozik Bartłomiej , Żylewski Marek , Nowakowska Maria , Kepczynski Mariusz 
Published: April 2013

AbstractPoly(allylamine hydrochloride) (PAH) has found many applications both in biotechnology and biomedical fields. However, its high toxicity toward various mammalian cells significantly limits its effective usage. This study focuses on improving the biological properties of PAH by its modification to strong polyelectrolytes. The strong polycations were prepared by the direct quaternization of PAH amino groups or by the attachment of glycidyltrimethylammonium chloride to these groups. The biological properties, such as cytotoxicity toward human skin fibroblasts (HSFs), proliferation and migration of the cells on a polymeric surface, and antibacterial activities against two pathogenic bacteria, Staphylococcus aureus and Escherichia coli, were determined. All the modified polyelectrolytes are considerably less toxic to HSFs as compared to PAH. Moreover, the directly quaternized polycations are stronger biocides against S. aureus than the parent polymer. Contrary to PAH, thin films of the modified polyelectrolytes improve or do not affect HSFs proliferation and can stimulate cell migration into the wound, as was demonstrated using an in vitro model. The relationship between the structure of the modified polymers (amount and localization of the quaternary ammonium groups) and the biological activity is discussed. Due to the improved biological properties, the obtained polycations may be potentially useful for a variety of biotechnological and biomedical applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 721–731, 2014.
In vitro characterization of macrophage interaction with mesenchymal stromal cell‐hyaluronan hydrogel constructs
Authors: King Suzanne N. , Hanson Summer E. , Chen Xia , Kim Jaehyup , Hematti Peiman , Thibeault Susan L. 
Published: April 2013

AbstractMacrophages play a critical role in mediating not only normal tissue healing, but also the host reaction against biomaterial scaffolds. There is increasing interest in regenerative medicine to combine mesenchymal stromal/stem cells (MSCs) with biomaterial scaffolds to modulate inflammatory response while restoring tissue architecture. The objective of the current study was to investigate the interaction between MSCs (derived from bone marrow, adipose or vocal fold tissue) encapsulated in hyaluronan‐based hydrogel and differentiating macrophages as measured by extracellular matrix (ECM) gene expression and cytokine, chemokine, and growth factor concentrations. Gene expression was analyzed using real‐time polymerase chain reaction from MSCs embedded in Carbylan‐GSX after 7 days of coculture with or without CD14+ cells. Protein concentrations were measured using a Bio‐plex assay from cell culture supernatants on days 3 and 7 for all conditions. Following 7 days, we identified upregulation of collagen‐I, collagen‐III, procollagen, and matrix metalloproteinase‐9 genes compared to control conditions. We demonstrate increased concentrations of immunoregulatory cytokines [interleukin (IL)‐1β, tumor necrosis factor‐α, macrophage inflammatory protein‐1α, IFN‐γ, IL‐12, and IL‐10] and remodeling growth factors (vascular endothelial growth factor, hepatocyte growth factor) in MSC‐3D constructs cocultured with macrophages compared to control conditions, with some temporal variation. Our results indicate an alteration of expression of ECM proteins important to tissue regeneration and cytokines critical to the inflammatory cascade when 3D constructs were cultured with differentiating macrophages. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 890–902, 2014.
The TERE1 protein interacts with mitochondrial TBL2: Regulation of trans‐membrane potential, ROS/RNS and SXR target genes
Authors: Fredericks William J. , McGarvey Terry , Wang Huiyi , Zheng Yongmu , Fredericks Nathaniel J. , Yin Hankun , Wang Li‐Ping , Hsiao Wayland , Lee Rob , Weiss Jayne S. , Nickerson Michael L. , Kruth Howard S. , RauscherIII Frank J. , Malkowicz S. Bruce 
Published: April 2013

AbstractWe originally discovered TERE1 as a potential tumor suppressor protein based upon reduced expression in bladder and prostate cancer specimens and growth inhibition of tumor cell lines/xenografts upon ectopic expression. Analysis of TERE1 (aka UBIAD1) has shown it is a prenyltransferase enzyme in the natural bio‐synthetic pathways for both vitamin K‐2 and COQ10 production and exhibits multiple subcellular localizations including mitochondria, endoplasmic reticulum, and golgi. Vitamin K‐2 is involved in mitochondrial electron transport, SXR nuclear hormone receptor signaling and redox cycling: together these functions may form the basis for tumor suppressor function. To gain further insight into mechanisms of growth suppression and enzymatic regulation of TERE1 we isolated TERE1 associated proteins and identified the WD40 repeat, mitochondrial protein TBL2. We examined whether disease specific mutations in TERE1 affected interactions with TBL2 and the role of each protein in altering mitochondrial function, ROS/RNS production and SXR target gene regulation. Biochemical binding assays demonstrated a direct, high affinity interaction between TERE1 and TBL2 proteins; TERE1 was localized to both mitochondrial and non‐mitochondrial membranes whereas TBL2 was predominantly mitochondrial; multiple independent single amino acid substitutions in TERE1 which cause a human hereditary corneal disease reduced binding to TBL2 strongly suggesting the relevance of this interaction. Ectopic TERE1 expression elevated mitochondrial trans‐membrane potential, oxidative stress, NO production, and activated SXR targets. A TERE1‐TBL2 complex likely functions in oxidative/nitrosative stress, lipid metabolism, and SXR signaling pathways in its role as a tumor suppressor. J. Cell. Biochem. 114: 2170–2187, 2013. © 2013 Wiley Periodicals, Inc.
Insulin induces human acyl‐coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer‐binding protein α
Authors: Ge Jing , Zhai Wei , Cheng Bei , He Ping , Qi Benling , Lu Han , Zeng Yongli , Chen Xin 
Published: April 2013

ABSTRACTInsulin resistance characterized by hyperinsulinemia is associated with increased risk of atherosclerosis. Acyl‐coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme involved in cellular cholesterol homeostasis and in atherosclerotic foam cell formation. To investigate the relationship between hyperinsulinemia and atherosclerosis, we investigated whether insulin induced ACAT1 gene expression and found that insulin up‐regulated ACAT1 mRNA, protein and enzyme activity in human THP‐1 cells and THP‐1–derived macrophages. Moreover, luciferase assays revealed that insulin enhanced the ACAT1 gene P1 promoter activity but not the P7 promoter. To explore the molecular mechanisms involved, deletion analysis of the human ACAT1 P1 promoter revealed an insulin response element (IRE) upstream of the P1 promoter (from −603 to −580), EMSA experiments demonstrated that CCAAT/enhancer binding protein α(C/EBPα) bound to the P1 promoter IRE. Insulin‐induced ACAT1 upregulation was blocked by the presence of PD98059 (an inhibitor of extracellular signal‐regulated kinase, ERK) and SB203580 (an inhibitor of p38 mitogen‐activated protein kinase, p38MAPK) but not by Wortmannin (an inhibitor of phosphatidylinositol 3‐kinase, PI3K) or U73122 (an inhibitor of phospholipase C‐γ, PLCγ). These studies demonstrate that insulin promotes ACAT1 gene expression at the transcriptional level. The molecular mechanism of insulin action is mediated via interaction of the functional IRE upstream of the ACAT1 P1 promoter with C/EBPα and is MAPK‐dependent. J. Cell. Biochem. 114: 2188–2198, 2013. © 2013 Wiley Periodicals, Inc.
Response of E. faecalis biofilms to different associations of auxiliary substances during root canal preparation: A confocal laser microscopy analysis
Authors: Hohscheidt Gabriela Luisa , Böttcher Daiana Elisabeth , Fatturi Parolo Clarissa Cavalcanti , Montagner Francisco , Grecca Fabiana Soares 
Published: April 2013

ABSTRACTObjective: This in vitro study evaluated the effect of different endodontic auxiliary chemical substances over Enterococcus faecalis (Ef) biofilm through confocal laser scanning microscopy (CLSM). Methods: Forty‐five bovine incisors were infected with Ef for 21 days. Teeth were divided into five groups: group 1: 2.5% NaOCl + EDTA, group 2: 2% CHX gel + EDTA, group 3: 2% CHX liquid + EDTA, group 4: 2.5% NaOCl + 2% CHX gel + EDTA, group 5: 2.5% NaOCl + 2% CHX liquid + EDTA and a negative and a positive control group (NCG; PCG). The samples were stained with SYTO9 and propidium iodide and analyzed by CLSM. Bacterial viability was quantitatively analyzed by the proportions of dead and live bacteria in the biofilm remnants. Scores were standardized according to the total bacterial load (TBL)—1: ≤25%, 2: >25 ≤50%, 3: >50 ≤75%, 4: >75% and debris—1: absence of debris; 2: presence of debris. Statistical analysis was carried out through the Kruskal–Wallis and the Fischer exact tests (P = 0.05). Results: No statistical differences were observed to CFU, debris and bacterial viability. Conclusion: None of the tested substances could completely eliminate Ef from the root canal space. Microsc. Res. Tech. 76:658–662, 2013. © 2013 Wiley Periodicals, Inc.