bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environment‐dependent relationships between corticosterone and energy expenditure during reproduction: Insights from seabirds in the context of climate change
Authors: Grunst Andrea S. , Grunst Melissa L. , Grémillet David , Chastel Olivier , Cruz‐Flores Marta , Gentès Sophie , Grissot Antoine , Jakubas Dariusz , Kato Akiko , Parteneau Charline , Wojczulanis‐Jakubas Katarzyna , Fort Jérôme 
Published: August 2024

Abstract

Alternative hypotheses have been proposed regarding how the hormone corticosterone (CORT) mediates energy expenditure during reproduction. Elevated baseline CORT (CORTb) could support daily energy expenditure (DEE), promoting reproductive effort or downregulate costly behaviours in low quality individuals facing allostatic overload.
We investigated relationships between CORTb, time activity budgets (TABs), DEE and diving behaviour across 2 years and colonies of little auk (Alle alle), an Arctic seabird in which elevating DEE may support reproduction in the face of climate change.
We also explored whether mercury (Hg) contamination might suppress DEE by affecting the hypothalamus‐pituitary–adrenal (HPA) axis and CORT production.
Furthermore, we performed phylogenetically controlled analysis across breeding seabird species to build broader understanding of CORT‐DEE relationships.
CORTb positively correlated with little auk activity, DEE and dive duration during a cold year in East Greenland, when CORTb was elevated in the population, but not during a warmer year, or at Svalbard. CORTb did not predict chick provisioning nor did Hg suppress CORTb.
Across breeding seabird species, CORTb and DEE were uncorrelated. Rather, contrary to predictions, CORTb was higher in species breeding at lower latitudes.
Intraspecific results suggest environment‐dependent relationships between CORTb, behaviour and DEE, with implications for understanding CORTb's role in climate change resiliency.
Interspecific analyses suggest absence of correlational selection between CORTb and DEE during reproduction, and that DEE thresholds that induce changes in CORTb might differ between species.

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Meaningful gazes: Conditioned reinforcement for following gaze as a prerequisite for joint attention
Authors: Luke Nicole , Chin Cherisse , Kulmiye Hanan , Keith Avery 
Published: August 2024

AbstractJoint attention is an important developmental skill. This series of studies investigated the teaching of component joint attention skills to 10 children with autism ranging in age from three to five years. The goal was to teach gaze shifting within a joint attention interaction. An additional goal was to expand some participants' community of reinforcers to include social reinforcers. Each study employed a single‐case research design using design variations for one dependent variable: gaze shifting. All 10 children improved their ability to shift their gaze to a therapist. Four participants demonstrated acquisition of social reinforcers.
Using orthographic support to reduce the impact of noise on oral vocabulary learning in adults
Authors: Salins Andrea , Cupples Linda , Leigh Greg , Castles Anne 
Published: August 2024

BackgroundAlthough most prevalent in childhood, the acquisition of new words in oral vocabulary takes place right across the lifespan. Of the many factors that influence oral vocabulary learning, one extrinsic factor is the listening environment. The current study aimed to examine whether the presence of noise impacts oral vocabulary learning in adult native speakers of English and, if so, whether this can be alleviated by the incidental presence of orthography when introducing new words.MethodsSixty 18–35‐year‐old native speakers of English were divided into two groups: orthography present and orthography absent and were taught novel picture–word pairs either in quiet or in noise. Word learning was assessed using picture naming and picture–word‐matching tasks.ResultsThe results revealed that the presence of orthography during training reduced the negative impact of noise and supported word learning and retention in adults.ConclusionThese results are promising for vocabulary instruction practices in less‐than‐ideal listening environments where structural modifications are not a feasible option.
ELSEWHERES OF THE UNBUILT: The Global Effects of Transnational Energy Infrastructure Projects
Authors: Larsen Maren , Jenss Alke , Schuetze Benjamin , Cupers Kenny 
Published: August 2024

AbstractPipelines and refineries, hydropower dams, and solar and wind power projects feeding into emerging transnational energy networks make up the thrust of a new push for infrastructural expansion in the global South. This article argues that understanding the effects of this expansion requires attending to the multiple elsewheres of transnational energy projects in various states of realization. By this we mean accounting for the ways in which these projects are financed, planned, contested, contracted, built, transformed and withheld at multiple, sometimes connected and sometimes disparate, sites across the globe. Focusing on the East African Crude Oil Pipeline (EACOP), the Central American Electric Interconnection System (SIEPAC) and the Mediterranean Electricity Ring (MedRing), our research shows that such projects are ‘global’ not only in their physical reach and forging of connections between disparate and expansive geographies, but also in the ways they bring into being new, transnational or global publics.
The impact of telehealth cost‐sharing on healthcare utilization: Evidence from high‐deductible health plans
Authors: Gidwani Risha , Yank Veronica , Burgette Lane , Kofner Aaron , Asch Steven M. , Wagner Zachary 
Published: August 2024

AbstractObjectiveEvaluate whether cost‐sharing decreases led high‐deductible health plans (HDHP) enrollees to increase their use of healthcare.Data Sources, Study SettingNational sample of chronically‐ill patients age 18–64 from 2018 to 2020 (n = 1,318,178).Study DesignDifference‐in‐differences analyses using entropy‐balancing weights were used to evaluate the effect of a policy shift to $0 cost‐sharing for telehealth on utilization for HDHP compared with non‐HDHP enrollees. Due to this shock, HDHP enrollees experienced substantial declines in cost‐sharing for telehealth, while non‐HDHP enrollees experienced small declines. Event study models were also used to evaluate changes over time.Data Collection/Extraction MethodsOutcomes included use of any outpatient care; use of $0 telehealth; use of $0 telehealth as a proportion of all outpatient care; and use of any telehealth. To test whether any differences were due to preferences for care modality versus cost‐sharing, we further evaluated use of non‐$0 telehealth as a placebo test.Principal FindingsThere was no difference in change in overall outpatient visits (p = 0.84), with chronicall‐ill HDHP enrollees using less care both before and after the policy shift. However, compared with non‐HDHP enrollees, HDHP enrollees increased their use of $0 telehealth by 0.08 visits over a 9‐month period, a 27% increase (95% CI 0.07–0.09, p < 0.001) and shifted 1.2 percentage points more of their care to $0 telehealth, a 15% increase (ß = 0.01, 95% CI 0.01, 0.01, p < 0.001). However, HDHP enrollees had lower uptake of non‐$0 telehealth than non‐HDHP enrollees (ß = −0.01, 95%CI −0.02, 0.00, p = 0.04).ConclusionsRecent‐but‐expiring federal legislation exempts telehealth from HDHP deductibles for care provided in 2023 and 2024. Our results indicate that extending the protections provided by this legislation could help reduce the gap in access to care for chronically‐ill persons enrolled in HDHPs.
Interventions based on alternative and sustainable strategies for postharvest control of anthracnose and maintain quality in tropical fruits
Authors: Fernandes Karina Felix Dias , Queiroga Talita Silveira , Lima Maiara da Costa , de Oliveira Kataryne Árabe Rimá , de Souza Evandro Leite 
Published: August 2024

AbstractColletotrichum spp. is a phytopathogen causing anthracnose in a variety of tropical fruits. Strategies used to control postharvest diseases in tropical fruits typically rely on the use of synthetic fungicides, which have stimulated the emergence of resistant pathogens. Safer alternative strategies to control anthracnose in tropical fruits have been described in the literature. This review presents and discusses the main innovative interventions concerning the application of sustainable alternative strategies in the postharvest control of pathogenic Colletotrichum species in tropical fruits, with a particular emphasis on the studies published in the last 5 years. The available studies have shown the use of various methods, including physical barriers, natural antimicrobials, and biological control with antagonistic microorganisms, to reduce anthracnose lesion severity and incidence in tropical fruits. The available literature showed high inhibitory activity in vitro, reduced anthracnose incidence and lesion diameter, and total disease inhibition in tropical fruits. Most studies focused on the inhibition of Colletotrichum gloeosporioides on avocado, papaya, and mango, as well as of Colletotrichum musae on banana; however, the inhibition of other Colletotrichum species was also demonstrated. The application of emerging sustainable alternative methods, including natural antimicrobial substances, also stimulated the induction of defense systems in tropical fruits, including enzymatic activity, such as polyphenol oxidase, peroxidase, and phenylalanine ammonia‐lyase. The retrieved data helped to understand the current state of the research field and reveal new perspectives on developing efficient and sustainable intervention strategies to control pathogenic Colletotrichum species and anthracnose development in tropical fruits.
The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus—A living systematic review and meta‐analysis
Authors: Lee Vivian Y. , Monjur Mohammad R. , Santos Joseph Alvin , Patel Anushka , Liu Rong , Di Tanna Gian Luca , Gupta Yashdeep , Goyal Alpesh , Ajanthan Saumiyah , Praveen Devarsetty , Lakshmi J. K. , de Silva H. Asita , Tandon Nikhil 
Published: August 2024

AbstractBackgroundWhile previously considered a transient condition, with no lasting adverse impact, gestational diabetes mellitus (GDM) is now a well‐established risk factor for developing type 2 diabetes mellitus (T2DM). The risk of developing T2DM appears to be particularly high in the first few years after childbirth, providing a compelling case for early intervention. This review provides an up‐to‐date systematic review and meta‐analysis to assess the effectiveness of interventions to reduce incidence of T2DM in women with a recent history of GDM.MethodsThe search was conducted on October 20, 2023 with an annual surveillance planned for the next 5 years to maintain a living systematic review. The inclusion criteria were randomized controlled trials of any type in women within 5 years of GDM‐complicated pregnancy that reported outcomes of T2DM diagnosis or measures of dysglycemia with a follow‐up of at least 12 months.ResultsSeventeen studies met our inclusion criteria and have been included in this review. There were 3 pharmacological and 14 lifestyle interventions. Intervention was not associated with significant reduction in the primary outcome of T2DM (risk ratio, 0.78; 95% confidence interval [CI]: 0.43–1.41; p = 0.41; I2 = 79%) compared with the control group (placebo or usual care). However, meta‐analysis of the four studies reporting hazard ratios suggested a reduction in diabetes incidence (hazard ratio, 0.68; 95% CI: 0.48–0.97; p = 0.03; I2 = 31%).ConclusionThis review provides equivocal evidence about the efficacy of interventions to reduce the risk of T2DM in women within 5 years of GDM‐complicated pregnancy and highlights the need for further studies, including pharmacotherapy.image
Trends in diabetic ketoacidosis‐ and hyperosmolar hyperglycemic state‐related mortality during theCOVID‐19 pandemic in the United States: A population‐based study
Authors: He Xinyuan , Huang Amy Huaishiuan , Lv Fan , Gao Xu , Guo Yuxin , Liu Yishan , Hu Xiaoqin , Xie Jingyi , Gao Ning , Jiao Yang , Wang Yuan , Zu Jian , Zhang Lei , Ji Fanpu , Yeo Yee Hui 
Published: August 2024

AbstractBackgroundDuring the pandemic, a notable increase in diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS), conditions that warrant emergent management, was reported. We aimed to investigate the trend of DKA‐ and HHS‐related mortality and excess deaths during the pandemic.MethodsAnnual age‐standardized mortality rates related to DKA and HHS between 2006 and 2021 were estimated using a nationwide database. Forecast analyses based on prepandemic data were conducted to predict the mortality rates during the pandemic. Excess mortality rates were calculated by comparing the observed versus predicted mortality rates. Subgroup analyses of demographic factors were performed.ResultsThere were 71 575 DKA‐related deaths and 8618 HHS‐related deaths documented during 2006–2021. DKA, which showed a steady increase before the pandemic, demonstrated a pronounced excess mortality during the pandemic (36.91% in 2020 and 46.58% in 2021) with an annual percentage change (APC) of 29.4% (95% CI: 16.0%–44.0%). Although HHS incurred a downward trend during 2006–2019, the excess deaths in 2020 (40.60%) and 2021 (56.64%) were profound. Pediatric decedents exhibited the highest excess mortality. More than half of the excess deaths due to DKA were coronavirus disease 2019 (COVID‐19) related (51.3% in 2020 and 63.4% in 2021), whereas only less than a quarter of excess deaths due to HHS were COVID‐19 related. A widened racial/ethnic disparity was observed, and females exhibited higher excess mortality than males.ConclusionsThe DKA‐ and HHS‐related excess mortality during the pandemic and relevant disparities emphasize the urgent need for targeted strategies to mitigate the escalated risk in these populations during public health crises.image
Probiotic treatment with viable α‐galactosylceramide‐producing Bacteroides fragilis reduces diabetes incidence in female nonobese diabetic mice
Authors: Hansen Camilla H. F. , Jozipovic Danica , Zachariassen Line F. , Nielsen Dennis S. , Hansen Axel K. , Buschard Karsten 
Published: August 2024

AbstractBackgroundWe aimed to investigate whether alpha‐galactosylceramide (α‐GalCer)‐producing Bacteroides fragilis could induce natural killer T (NKT) cells in nonobese diabetic (NOD) mice and reduce their diabetes incidence.MethodsFive‐week‐old female NOD mice were treated orally with B. fragilis, and islet pathology and diabetes onset were monitored. Immune responses were analyzed by flow cytometry and multiplex technology. Effects of ultraviolet (UV)‐killed α‐GalCer‐producing B. fragilis and their culture medium on invariant NKT (iNKT) cells were tested ex vivo on murine splenocytes, and the immunosuppressive capacity of splenocytes from B. fragilis‐treated NOD mice were tested by adoptive transfer to nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice.ResultsB. fragilis reduced the diabetes incidence from 69% to 33% and the percent of islets with insulitis from 40% to 7%, which doubled the serum insulin level compared with the vehicle‐treated control mice. Furthermore, the early treatment reduced proinflammatory mediators in the serum, whereas the proportion of CD4+ NKT cell population was increased by 33%. B. fragilis growth media stimulated iNKT cells and anti‐inflammatory M2 macrophages ex vivo in contrast to UV‐killed bacteria, which had no effect, strongly indicating an α‐GalCer‐mediated effect. Adoptive transfer of splenocytes from B. fragilis‐treated NOD mice induced a similar diabetes incidence as splenocytes from untreated NOD mice.ConclusionsB. fragilis induced iNKT cells and M2 macrophages and reduced type 1 diabetes in NOD mice. The protective effect seemed to be more centered on gut–pancreas interactions rather than a systemic immunosuppression. B. fragilis should be considered for probiotic use in individuals at risk of developing type 1 diabetes.image
Discovery of a new bacterium, Microbacterium betulae sp. nov., in birch wood associated with hypersensitivity pneumonitis in woodworkers
Authors: Paściak Mariola , Pawlik Krzysztof J. , Martynowski Dariusz , Łaczmański Łukasz , Ciekot Jarosław , Szponar Bogumiła , Wójcik‐Fatla Angelina , Mackiewicz Barbara , Farian Ewelina , Cholewa Grażyna , Cholewa Alicja , Dutkiewicz Jacek 
Published: August 2024

AbstractA Gram‐positive, aerobic, rod‐shaped mesophilic bacterium was isolated from birch wood, referred to as the AB strain. Allergological tests suggest that this strain may cause allergic alveolitis in sawmill workers. Employing a polyphasic taxonomic approach, the AB strain's 16S rRNA gene sequence showed high similarity to Microbacterium barkeri and M. oryzae, with 97.25% and 96.91%, respectively, a finding supported by rpoB and gyrB sequence analysis. Further genome sequence comparison with the closely related M. barkeri type strain indicated a digital DNA–DNA hybridization value of 25.5% and an average nucleotide identity of 82.52%. The AB strain's cell wall peptidoglycan contains ornithine, and its polar lipids comprise diphosphatidylglycerol, phosphatidylglycerol, and unidentified glycolipids. Its major fatty acids include anteiso C15:0, anteiso C17:0, and iso C16:0, while MK‐10 is its predominant respiratory quinone. Comprehensive analysis through 16S rRNA, whole‐genome sequencing, phenotyping, chemotaxonomy, and MALDI‐TOF MS profiling indicates that the AB strain represents a new species within the Microbacterium genus. It has been proposed to name this species Microbacterium betulae sp. nov., with ABT (PCM 3040T = CEST 30706T) designated as the type strain.
Wide‐ranging genetic variation in sensitivity to rapamycin in Drosophila melanogaster
Authors: Harrison Benjamin R. , Lee Mitchell B. , Zhang Shufan , Young Bill , Han Kenneth , Sukomol Jiranut , Paus Vanessa , Tran Sarina , Kim David , Fitchett Hannah , Pan Yu‐Chen , Tesfaye Philmon , Johnson Alia W. , Zhao Xiaqing , Djukovic Danijel , Raftery Daniel , Promislow Daniel E. L. 
Published: August 2024

AbstractThe progress made in aging research using laboratory organisms is undeniable. Yet, with few exceptions, these studies are conducted in a limited number of isogenic strains. The path from laboratory discoveries to treatment in human populations is complicated by the reality of genetic variation in nature. To model the effect of genetic variation on the action of the drug rapamycin, here we use the growth of Drosophila melanogaster larvae. We screened 140 lines from the Drosophila Genetic References Panel for the extent of developmental delay and found wide‐ranging variation in their response, from lines whose development time is nearly doubled by rapamycin, to those that appear to be completely resistant. Sensitivity did not associate with any single genetic marker, nor with any gene. However, variation at the level of genetic pathways was associated with rapamycin sensitivity and might provide insight into sensitivity. In contrast to the genetic analysis, metabolomic analysis showed a strong response of the metabolome to rapamycin, but only among the sensitive larvae. In particular, we found that rapamycin altered levels of amino acids in sensitive larvae, and in a direction strikingly similar to the metabolome response to nutrient deprivation. This work demonstrates the need to evaluate interventions across genetic backgrounds and highlights the potential of omic approaches to reveal biomarkers of drug efficacy and to shed light on mechanisms underlying sensitivity to interventions aimed at increasing lifespan.
Accelerated forest restoration may benefit spotted owls through landscape complementation
Authors: Jones G. M. , Stanley C. K. , Peery M. Z. , Maxwell C. , Wilson K. N. 
Published: August 2024

AbstractAnimals often rely on the presence of multiple, spatially segregated cover types to satisfy their ecological needs; the juxtaposition of these cover types is called landscape complementation. In ecosystems that have been homogenized because of human land use, such as fire‐suppressed forests, management activities have the potential to increase the heterogeneity of cover types and, therefore, landscape complementation. We modeled changes to California spotted owl (Strix occidentalis occidentalis) nesting/roosting habitat, foraging habitat and habitat co‐occurrence (i.e. landscape complementation) within a 971 245‐ha forest landscape restoration project area, the Tahoe‐Central Sierra Initiative (TCSI) landscape, through mid‐century as a function of fuels reduction, fire and climate change. Compared to a minimal management scenario, accelerated management within the TCSI landscape was predicted to increase the number of potential 400‐ha spotted owl territories containing a high degree of landscape complementation (defined as containing >20% nest/roost habitat and >20% foraging habitat) at lower elevations (<5000 ft.) by an average of 90 to 118 territories by 2050, depending on the climate scenario examined. At higher elevations (>5000 ft.), potential benefits of treatments to spotted owl nesting/roosting and foraging habitat were less evident, but accelerated management did not result in habitat loss. Our results suggest that accelerated fuels reduction and forest restoration treatments within this large landscape are expected to benefit spotted owls by improving the spatial juxtaposition of nesting/roosting and foraging cover types by 2050 compared to a minimal management scenario. Fuels reduction and forest restoration in this landscape thus can both increase the resilience of forest ecosystems to disturbances as well as benefit the habitat of a sensitive old‐forest species.
What is the prevalence of anabolic‐androgenic steroid use among women? A systematic review
Authors: Piatkowski Timothy , Whiteside Bianca , Robertson Jonathan , Henning April , Lau Eric H. Y. , Dunn Matthew 
Published: August 2024

AbstractBackground and aimEvidence suggests there has been an increase in anabolic‐androgenic steroid (AAS) use among women, driven by the evolving landscape of women's participation in sport. However, the extent of use is unknown. This systematic review aimed to estimate the prevalence of women's AAS use.MethodWe conducted a systematic review of peer‐reviewed articles in English, focusing on AAS use among women aged 18 and above. We excluded grey literature and studies that measured doping through some form of analysis (e.g. urine or hair). Searched databases were MEDLINE, CINAHL, PsycINFO, SocINDEX, SPORTDiscus, Embase and Cochrane Library. Titles and abstracts for all articles were screened, followed by full‐text assessment and data extraction of included articles by multiple authors for accuracy. The pooled prevalence of lifetime use was determined using a random effects model and the risk of bias was assessed using the Joanna Briggs Institute Prevalence Critical Appraisal Tool.ResultsBased on 18 studies, participant numbers averaged 669 per study (median = 189; range = 16 to 7051). The overall pooled AAS use prevalence was 4% (95% confidence interval [CI] = 2–9%) with high heterogeneity overall (I2 = 95%). In the subgroup analysis, AAS use prevalence was 16.8% (95% CI = 11.0–24.9%, I2 = 44%) in the bodybuilder subgroup, 4.4% (95% CI = 1.2–15.1%, I2 = 93%) in athletes/recreational gym user subgroup, and 1.4% (95% CI = 0.4–4.7%, I2 = 96%) in the general population/other subgroup. Meta‐regression demonstrated significantly higher AAS use in bodybuilders compared with the other subgroup (P = 0.011).ConclusionAnabolic‐androgenic steroid use among women appears to be substantially higher among bodybuilders and athletes/recreational gym users than the general female population.