bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Influence of Fok1/Apa1 Polymorphic Variants on Adolescent Mental Health and Response to Vitamin D Supplementation in Embryonic Hippocampal Cell Lines
Authors: Gizzi Giulia , Fiorani Federico , Cataldi Samuela , Mandarano Martina , Delvecchio Elisa , Mazzeschi Claudia , Albi Elisabetta 
Published: July 2024

Several single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) have been observed in association with susceptibility to various pathologies, including autism, major depression, age-related changes in cognitive functioning, and Parkinson’s and Alzheimer’s diseases. This study aimed to establish the association between Fok1/Apa1 polymorphic variants and anxious/depressive symptoms in nonclinical adolescents from central Italy, with the goal of identifying the risk of developing both symptoms. We found no significant difference in genotype distribution or dominant/recessive models of Fok1/Apa1 VDR polymorphic variants between subjects with anxious/depressive symptoms and controls. HN9.10e cell lines carrying the AA genotype for Fok1 and the CC genotype for Apa1 responded better to treatment with vitamin D3 than cell lines carrying the AG genotype for Fok1 and CA genotype for Apa1. Cell lines carrying the GG genotype for Fok1 and the AA genotype for Apa1 did not respond at all, suggesting avenues for future studies in both the general population and individuals with mental and/or neuropsychiatric disorders. These studies suggest that the level of response to vitamin D3 administered to prevent and/or treat mental or neurological disorders could depend on the polymorphic variants of the vitamin D receptor.
Clinical Study and Serological Diagnosis of Vector-Borne Pathogens in Sardinian Dogs
Authors: Chisu Valentina , Tanda Antonio , Sechi Sara , Pinna Parpaglia Maria Luisa , Masu Gabriella , Loi Federica , Masala Giovanna 
Published: July 2024

Canine vector-borne diseases (CVBDs) comprise a group of infectious diseases caused by a wide range of pathogens transmitted by arthropod vectors. Clinical signs commonly involve symptoms such as fever, anorexia, weight loss, blood disorders, hepatosplenomegaly, and others that can lead to death in dogs with comorbidities. Some pathogens responsible for CVBDs constitute a serious threat to human health due to their zoonotic transmission. This study aimed to determine the prevalence of zoonotic vector-borne diseases (Rickettsia rickettsii, Anaplasma phagocytophilum, Ehrlichia canis, Bartonella henselae, and Leishmania infantum) in domestic Sardinian dogs with and without clinical signs of these pathogens. Blood serum samples were collected from 142 dogs and examined through serological analysis. Clinical signs suggestive of these pathogens were also evaluated. The results obtained showed that 33 (33/140; 23.6%), 22 (22/134; 16.4%), 14 (14/142; 9.9%), 20 (20/66; 30.3%), and 26 (26/108; 24.1%) dogs were seropositive for Rickettsia sp., Anaplasma sp., Ehrlichia sp., Bartonella sp., and Leishmania sp. antibodies, respectively. Among these dogs, 12 dogs presented with at least one clinical sign (8.5%), while 18 (12.7%) showed more than two symptoms at the same time. Furthermore, among the asymptomatic dogs (93/142; 65.5%), 13% (n = 12) tested positive for A. phagocytophilum, 12% (n = 11) tested positive for B. henselae, 9% (n = 8) tested positive for E. canis, 12% (n = 11) tested positive for L. infantum, and 19% (n = 18) tested positive for R. rickettsii. This survey represents the first study assessing different canine vector-borne pathogens in dogs from North Sardinia. Since the pathogens detected here represent emerging zoonotic diseases, these results highlight the need to undertake further studies to increase the knowledge of these under-reported vector-borne pathogens in Sardinia.
The Comparison of Antibody Responses to Natural COVID-19 Infection and Vaccination
Authors: Чмаг A.A. , Салман Б.Д. , Абдулрида Л.А. 
Published: July 2024

Введение. Гуморальный иммунный ответ является важной составляющей формирования иммунитета после вакцинации против SARS-CoV-2. Цель. Исследовать состояние иммунного ответа и защитные свойства антител после применения вакцин Оксфорд/АстраЗенека ChAdOx1, БиоНтех BNT162b2 и Синофарм. Материалы и методы. Для исследования были отобраны образцы крови (по 2 мл) 122 испытуемых с последующим получением сыворотки. Все иммунологические и ферментативные реакции проводили с использованием прибора mini VIDAS. Результаты. У 61 испытуемого после применения вакцины БиоНТех BNT162b2 уровень антител превышал уровень антител после применения вакцин Оксфорд/АстраЗенека ChAdOx1 и Синофарм. У женщин уровень антител после вакцинации был выше, чем у мужчин. Ранее перенесенная инфекция вызывала значительное повышение уровня антител в группе вакцинированных. Заключение. Констатированное увеличение количества выявленных в сыворотке крови антител сопровождалось усилением иммунной защиты организма от инфекции после проведенной вакцинации.
Introduction. Antibody responses are an important part of the immunity after SARS-CoV-2 vaccination. Purpose. To investigate antibody responses and associates of protection after vaccination with the Oxford/AstraZeneca ChAdOx1, BioNTech BNT162b2, and Sinopharm vaccines. Materials and methods. Blood samples (2 ml) were collected from 122 participants and the serum was obtained. All the immunological and enzymatic reactions were done using the mini VIDAS device. Results. In 61 participants, the BioNTech BNT162b2 vaccine was found to produce higher antibody levels compared with the levels produced by the Oxford/AstraZeneca ChAdOx1 and Sinopharm vaccines. Females had higher antibody levels following vaccination. Prior infection substantially increased antibody levels in the vaccinated group. Conclusion. The stated increase in the number of antibodies detected in the blood serum was accompanied by an increase in the body’s immune defence against infection after vaccination.
Pemanfaatan Teknik Konseling Behavior dalam Meningkatkan Kepercayaan Diri Terhadap Santri
Authors: Zuhri Bahrul Ulum , Sriharini  
Published: July 2024

Humans, including students at the Tamrinut Tullab Islamic boarding school, require self confidence to perform daily tasks. this relatively new Islamic boarding school, Tamrinut Tullab, in Ngaglik, Sleman Daerah Istimewa Yogyakarta, has not categorized students to learn to participate in activities, and some students have never had experience in the cottage so they experienced cultural shock that has an impact on their confidence. The main issue being researched in this journal is how to use behavior counseling techniques to help students at the Tamrinut tullab Islamic boarding school in Ngaglik, Sleman, Daerah Istimewa Yogyakarta feel more confident about themselves. This journal aims to describe how behavior counseling techniques are used to help students feel more confident. The findings of this study demonstrate how behavior counseling techniques can be used to help students feel more confident, develop an adaptable attitude, participate fully in activities at their Islamic boarding school, and make many other positive changes.
El origen del mal a través de los escritos de Ellen G. White
Authors: Aparicio-Jiménez Ricardo-Alfonso 
Published: July 2024

Es esencial para los seres humanos conocer las razones por las cuales el mundo actual está cada día mas sumergido en el mal, la injusticia y el egoísmo. La Biblia y los escritos del espíritu de profecía nos muestran el origen del mal en el universo, y cual ha sido su consecuencia en el ser humano.
Mathematical modeling and computer-aided simulation of one-degree-of-freedom mechanical system
Authors: BALMUS Nicolae 
Published: July 2024

Mathematical modeling and computer-assisted simulation of various phenomena and processes in nature are activities stipulated in the pre-university curriculum and university analytical programs for the disciplines of physics, mathematics, computer science. In this context, the paper describes and implements in the Pascal programming language an original algorithm for the numerical resolving of second-order differential equations. Interactive simulation applications are built in the Delphi programming environment. Based on the examples, detailed described in the paper, users can perform interactive simulation activities for any process, which from a mathematical point of view is described by a differential equation of the second degree.
IMPERATIVES FOR THE TRANSFORMATION OF SECTORAL MANAGEMENT, ADAPTED TO POSSIBLE EMERGENCY SITUATIONS, IN THE CONDITIONS OF THE MODERN ENERGY STRUCTURE AND IN THE FUTURE
Authors: Грабчак Е.П. , Епишкин И.И. , Логинов Е.Л. 
Published: July 2024

Исследуются идущие процессы трансформации отраслевого управления, расширяющие возможности его адаптации к возможным чрезвычайным ситуациям в условиях современной структуры энергетики и в перспективе. Рассмотрена организационно-техническая структура энергетики России, структурированы технологические тренды и тенденции, влияющие на техническую структуру отрасли, сформулированы стратегические задачи при развитии оперативного управления энергетикой России в отношении развития информационной инфраструктуры и процессов сбора и обработки информации.
The article examines the ongoing processes of transformation of sectoral management, expanding the possibilities of its adaptation to possible emergency situations in the conditions of the modern energy structure and in the future. The organizational and technical structure of the Russian energy sector is considered, technological trends and trends that affect the technical structure of the industry are structured, strategic tasks are formulated in the development ofoperational management of the Russian energy sector in relation to the development of information infrastructure and processes for collecting and processing information.
LEGAL REGULATION IN THE FIELD OF PROTECTION OF THE POPULATION AND TERRITORIES FROM EMERGENCY SITUATIONS (INNOVATIONS)
Authors: Назаренко Е.К. 
Published: July 2024

Проведен анализ нововведений в чрезвычайном законодательстве в 2022 году, направленных на повышение эффективности деятельности МЧС России.
The analysis of changes in legislation in the field of protection of the population and territories from emergencies in 2022, aimed at improving the efficiency of the EMERCOM of Russia.
PROBLEM QUESTIONS OF MODERN THEORY RISK CONCEPTS
Authors: Кармишин А.М. , Скворцова С.В. , Кулинкович А.В. , Тимошенко З.В. 
Published: July 2024

Осуществлен анализ понятия «безопасность», раскрываются недостатки его официальных определений. Рассматриваются количественные показатели, по которым можно судить о промышленной безопасности. Отмечается, что в настоящее время для описания безопасности потенциально опасных промышленных объектов широко используется теория риска и его количественные показатели: индивидуальный, потенциальный территориальный, коллективный и др. риски. Описание промышленной безопасности (опасности) в терминах риска не учитывает ряд принципиальных аспектов реализованной или потенциальной (прогнозируемой) опасности промышленных объектов. В основу разработки методов оценки опасности потенциально опасных промышленных объектов предлагается положить идеи квалиметрии: обосновать иерархию показателей опасности от простейших, до наиболее полных и интегральных, учитывающий реализацию опасности не только в пространстве, но и во времени при изолированном и комбинированном действии поражающих (производственных) факторов. Основываясь на системном анализе последовательности описания (изучения) опасности потенциально опасных промышленных объектов при их штатном и аварийном функционировании и опираясь на идеи квалиметрии, показывается, что изучение и описание опасности техногенных аварий (катастроф) должно осуществляться на трех взаимосвязанных уровнях обобщения, для каждого из которых необходимо обосновать свою система количественных показателей опасности.
The article analyzes the concept of "security", reveals the shortcomings of its official definitions. Quantitative indicators by which one can judge industrial safety are considered. It is noted that at present, to describe the safety of potentially hazard ous industrial facilities, the theory of risk and its quantitative indicators are widely used: individual, potential territorial, collective and other risks. The description of industrial safety (hazard) in terms of risk does not take into account a number of fundamental aspects of the realized or potential (projected) danger of industrial facilities. It is proposed to use the ideas of qualimetry as the basis for the development of methods for assessing the danger of potentially hazardous industrial facilities: to substantiate the hierarchy of hazard indicators from the simplest to the most complete and integral, taking into account the realization of danger not only in space, but also in time with isolated and combined action of damaging (production) factors. Based on a systematic analysis of the sequence of description (study) of the danger of potentially hazardous industrial facilities during their normal and emergency operation and based on the ideas of qualimetry, it is shown that the study and description of the danger of man-made accidents (catastrophes) should be carried out at three interrelated levels of generalization, for each of which it is necessary to substantiate its system of quantitative indicators of danger.
THE MAIN DIRECTIONS OF IMPROVING THE REGULATORY LEGAL FRAMEWORK GOVERNING THE TRAINING OF THE POPULATION IN THE FIELD OF CIVIL DEFENSE
Authors: Григорьев В.Н. , Назаренко Е.К. 
Published: July 2024

Проведены исследования нормативной правовой базы, регулирующей подготовку различных категорий населения страны в области гражданской обороны. Обозначены проблемные вопросы и предложены направления её совершенствования; при этом, учтены новые условия и правовые режимы ведения специальной военной операции.
Studies of the legal framework governing the training of various categories of the country's population in the field of civil defense have been carried out. Problematic issues are identified and directions for its improvement are proposed; at the same time, new conditions and legal regimes for conducting a special military operation are taken into account.
MODELS FOR MANAGING THE EFFECTIVENESS OF FORTIFICATION EQUIPMENT POSITIONS OF SECURITY UNITS AND ASSESSING ITS IMPACT ON THE PROTECTION OF HYDRAULIC STRUCTURE
Authors: Седнев В.А. , Копнышев С.Л. , Сергеенкова Н.А. , Седнев Ал.В. 
Published: July 2024

Фортификационное оборудование районов является одной из сложных и важных задач инженерного обеспечения защиты гидротехнических сооружений. Основной целью их фортификационного оборудования является обеспечение выполнения подразделениями охраны задач с наименьшими потерями от средств поражения нарушителей. Поэтому актуальной является постановка вопроса оценки эффективности фортификационного оборудования гидротехнического сооружения, то есть определение количественных показателей влияния фортификационного оборудования на достижение поставленной цели. Под эффективностью фортификационного оборудования понимается его влияние на сохранение или быстрое восстановление боеспособности подразделений охраны гидротехнического сооружения, и в статье обоснованы три модели управления системой физической защиты гидротехнического сооружения.
Fortification equipment of districts is one of the complex and important tasks of engineering support for the protection of hydraulic structures. The main purpose of their fortification equipment is to ensure that the security units perform tasks with the least losses from the means of destruction of violators. Therefore, it is relevant to raise the issue of evaluating the effectiveness of fortification equipment of a hydraulic structure, that is, determining quantitative indicators of the impact of fortification equipment on achieving the goal. The effectiveness of fortification equipment is understood to mean its impact on the preservation or rapid restoration of the combat capability of the units of the protection of hydraulic structures, and the article substantiates three models of management of the system of physical protection of hydraulic structures.
ALGORITHM OF INTERNAL AUDIT OF THE UNIFIED SYSTEM OF INDUSTRIAL SAFETY MANAGEMENT AT A COAL OPEN PIT
Authors: Ковалев М.А. , Москвичев В.В. 
Published: July 2024

Основная цель обеспечения безопасности при добыче угля на разрезе снижение рисков аварий до научно обоснованных уровней. Разработана не имеющая аналогов авторская методика оценки эффективности системы управления промышленной безопасностью угольных разрезов через алгоритм внутреннего аудита. Решение задач управления рисками аварий на объектах открытой угледобычи предлагается реализовать в рамках системы «человек-машина-среда» (Ч-М-С). Актуальность работы определяется тем, что разработанная методика учитывает специфику горнодобывающей отрасли и адаптирована к её критическим вызовам и потребностям. Является важным инструментом обеспечения оптимальных условий работы и поддержания требуемого уровня безопасности на открытых горных работах.
The main goal to be pursued in organizing surface coal mining operations from a safety point of view is to reduce the risk of accidents to acceptable science-based levels. To realize this goal, it’s necessary to form the structure and mechanisms of open pit management on the basis of quantitative risk assessment. To solve the problems of accident risk management at the objects of surface coal mining it’s proposed to use the system "man-machine-environment" (HM-E). The aim of the work is to determine the efficiency of the technology of work organization in the system "H-M-E" through the efficiency of the unified system of industrial safety management (USIMS) of a coal open pit. For this purpose, the author's methodology for assessing the effectiveness of the industrial safety management system of surface coal mining through the internal audit algorithm has been developed, which previously had no analogues.
PEOPLE AND ANIMALS IN THE PROSE OF S. T. AKSAKOV AND I. S. TURGENEV: SEMANTICS OF NARRATORY
Authors: Архипова Е.Ю. 
Published: July 2024

В статье рассматриваются и сравниваются анималистические мотивы в творчестве С. Т. Аксакова и И. С. Тургенева. В ходе анализа делаются выводы о том, то охотник у С. Т. Аксакова является лишь наблюдателем, но не частью природы, в то время как у И. С. Тургенева он гармонично вписан в природный мир. Если у И. С. Тургенева можно встретить «звериные» мотивы в портретах персонажей, то для Аксакова это скорее нетипично и встречается в единичных случаях. В «Записках ружейного охотника» на первом плане – животные, в то время как у Тургенева охота представляет лишь некую рамку, а основное внимание уделено людям, их характерам, быту. Кроме того, у Тургенева не встречаются такие подробные и красочные портреты рыб, птиц и зверей, как в текстах Аксакова, который в целом разделяет человеческий мир и мир животный: один связан с нравственной стороной, другой – с эстетической. Они могут периодически пересекаться, но чаще всего человеческий мир описывается с точки зрения характера и поведения его представителей, а мир животных – с точки зрения внешних (визуальных или поведенческих) особенностей, отличающих одни виды от других.
The article examines and compares animalistic motifs in the prose of S. T. Aksakov and I. S. Turgenev. During the analysis, conclusions are drawn that the hunter in S. T. Aksakov is only an observer, but not part of nature, while in I. S. Turgenev he is harmoniously integrated into the natural world. If in prose of I.S. Turgenev one can find “animal” motives in the portraits of characters, then for Aksakov this is rather atypical and occurs in isolated cases. In Aksakov’s “Notes of a gun Hunter,” animals are in the foreground while in Turgenev’s prose hunting represents only a certain frame, and the main attention is paid to people, their characters, and everyday life. In addition, Turgenev’s prose does not have such detailed and colorful portraits of fish, birds and animals as in the texts of Aksakov, who generally separates the human world and the animal world: one is associated with the moral side, the other with the aesthetic. They may overlap periodically, but most often the human world is described in terms of the character and behavior of its representatives, and the animal world in terms of external (visual or behavioral) features that distinguish one species from others.
Kompetensi dan Karakteristik Kepemimpinan Kepala Sekolah Islam Abad 21
Authors: Sastradiharja EE. Junaedi , Zairin Gentiga Muhammad 
Published: July 2024

Menjadi kepala sekolah Islam di era abad 21 bukan hal yang mudah, perlu adanya capacity building yang kuat, baik berupa kompetensi, karakteristik kepemimpinan maupun sikap dan kematangan kerja. Abad 21 adalah abad persaingan global, yang sangat berbeda dengan abad-abad sebelumnya. Perkembangan Information and Communication Technology (ICT) terjadi sangat luar biasa disegala bidang kehidupan. Pada abad ini, semua orang merasakan serba sophisticated menjadikan dunia ini terasa semakin sempit dan tanpa batas. Kecanggihan Information and Communication Technology (ICT) telah mengubah sesuatu yang sebelumnya sulit dan dianggap mustahil bisa terjadi, akan menjadi mudah, cepat dan akurat. Tidak dapat dipungkiri pada abad ke-21 ini permasalahan yang dihadapi manusia juga semakin complicated dan ruwet, misalnya terjadinya krisis ekonomi dan pemanasan global tak bisa dihindari, terorisme, rasisme, drug abuse, trafficking, masih rendahnya kesadaran multikultural. Sekolah Islam yang memiliki fungsi mencerdasakan kehidupan bangsa, mengembangkan karakter dan kecerdasan spiritual siswa, perlu dipimpin oleh kepala sekolah yang memiliki kompetensi dan karakteristik kepemimpinan sesuai kebutuhan abad 21. Penelitian ini mengunakan metode studi pustaka (library research) merupakan penelitian yang objeknya dicari dari berbagai informasi pustaka seperti buku, tesis, disertasi, jurnal ilmiah, majalah, koran, dan dokumen. Hasil penelitian menunjukkan bahwa kompetensi dan karakteristik kepemimpian kepala sekolah Islam adalah
The Ambiguous Cue Task: Measurement reliability of an experimental paradigm for the assessment of interpretation bias and associations with mental health
Authors: Armbruster-Genç Diana J. N. , Rammensee Rebecca A. , Jungmann Stefanie M. , Drake Philine , Wessa Michèle , Basten Ulrike 
Published: July 2024

AbstractInterpretation biases in the processing of ambiguous affective information are assumed to play an important role in the onset and maintenance of emotional disorders. Reports of low reliability for experimental measures of cognitive biases have called into question previous findings on the association of these measures with markers of mental health and demonstrated the need to systematically evaluate measurement reliability for measures of cognitive biases. We evaluated reliability and correlations with self-report measures of mental health for interpretation bias scores derived from the Ambiguous Cue Task (ACT), an experimental paradigm for the assessment of approach-avoidance behavior towards ambiguous affective stimuli. For a non-clinical sample, the measurement of an interpretation bias with the ACT showed high internal consistency (rSB = .91 – .96, N = 354) and acceptable 2-week test–retest correlations (rPearson = .61 – .65, n = 109). Correlations between the ACT interpretation bias scores and mental health-related self-report measures of personality and well-being were generally small (r ≤ |.11|) and statistically not significant when correcting for multiple comparisons. These findings suggest that in non-clinical populations, individual differences in the interpretation of ambiguous affective information as assessed with the ACT do not show a clear association with self-report markers of mental health. However, in allowing for a highly reliable measurement of interpretation bias, the ACT provides a valuable tool for studies considering potentially small effect sizes in non-clinical populations by studying bigger samples as well as for work on clinical populations, for which potentially greater effects can be expected.