bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Ruthenium Carboxylate Complexes as Efficient Catalysts for the Addition of Carboxylic Acids to Propargylic Alcohols.
Authors: Jeschke Janine , Gaebler Christian , Korb Marcus , Rueffer Tobias , Lang Heinrich 
Published: October 2015

AbstractNewly synthesized ruthenium complexes are applied as catalysts in the addition of carboxylic acids to propargylic alcohols to give the corresponding β‐oxo esters in high yields even in air.
ChemInform Abstract: Stereoselective Synthesis of Mexiletine and Structural Analogues with Chiral tert‐Butanesulfinamide.
Authors: Ryan Daniel A. , Okolotowicz Karl J. , Mercola Mark , Cashman John R. 
Published: October 2015

AbstractThe approach relies on a two‐step condensation‐reduction procedure, and the stereochemical outcome is reversed by the appropriate reducing agent.
ChemInform Abstract: Preparation of 1‐Tosyloxy‐4‐substituted‐2‐butenes Using Ag(I) Salts.
Authors: Stehouwer Jeffrey S. , Goodman Mark M. 
Published: October 2015

AbstractDibromo‐ and dichloro‐2‐butenes (I) and (V) react with silver tosylate to give tosyloxy substituted 2‐butenes, which can be further converted into 4‐fluoro derivatives upon treatment with AgF or KF.
ChemInform Abstract: Enantioselective Synthesis of β‐Arylamines via Chiral Phosphoric Acid‐Catalyzed Asymmetric Reductive Amination.
Authors: Kim Kyung‐Hee , Lee Chun‐Young , Cheon Cheol‐Hong 
Published: October 2015

AbstractA novel method for the synthesis of chiral β‐aryl amines (III) is achieved by Hantzsch ester promoted enantioselective reductive amination of benzyl methyl ketones with anisidine in the presence of a BINOL derived phosphonic acid catalyst.
ChemInform Abstract: Vicinal Functionalization of N‐Alkoxyenamines: Tandem Umpolung Phenylation‐Nucleophilic Addition Reaction Sequence.
Authors: Sato Shohei , Takeda Norihiko , Miyoshi Tetsuya , Ueda Masafumi , Miyata Okiko 
Published: October 2015

AbstractVarious amine derivatives are obtained by vicinal functionalization of N‐alkoxyenamines, derived in situ from aldehydes and isoxazolidine, with the formation of two new carbon‐carbon bonds using an organo‐aluminum reagent and subsequent allyl‐magnesium bromide or tributyltin cyanide as external carbon‐centered nucleophiles.
ChemInform Abstract: Electrosynthesis of Enaminones Directly from Methyl Ketones and Amines with Nitromethane as a Carbon Source.
Authors: Xu Kun , Zhang Zhenlei , Qian Peng , Zha Zhenggen , Wang Zhiyong 
Published: October 2015

AbstractThe one‐step metall‐free strategy tolerates arylmethyl ketones endowed with a variety of functional groups and cyclic as well as acyclic secondary aliphatic amines.
ChemInform Abstract: Catalytic Enantioselective Reaction of α‐Phenylthioacetonitriles with Imines Using Chiral Bis(imidazoline)‐Palladium Catalysts.
Authors: Kondo Masaru , Kobayashi Natsumi , Hatanaka Tsubasa , Funahashi Yasuhiro , Nakamura Shuichi 
Published: October 2015

AbstractThe first highly enantioselective reaction of α‐thioacetonitriles with imines in the presence of a bis(imidazoline)‐palladium pincer complex as a chiral Lewis acid catalyst is presented.
ChemInform Abstract: Ru‐Catalyzed Regioselective CH‐Hydroarylation of Alkynes with Benzylthioethers Using Sulfur as Directing Group.
Authors: Villuendas Pedro , Urriolabeitia Esteban P. 
Published: October 2015

AbstractThe sulfur atom as efficient directing group allows the regioselective ortho‐substitution of the thioethers.
ChemInform Abstract: tert‐Butyl Sulfoxides: Key Precursors for Palladium‐Catalyzed Arylation of Sulfenate Salts.
Authors: Gelat Fabien , Lohier Jean‐Francois , Gaumont Annie‐Claude , Perrio Stephane 
Published: October 2015

AbstractSulfenate salts, generated in situ by pyrolysis of tert‐butyl sulfoxides in the presence of K3PO4 undergo Pd‐catalyzed cross‐coupling reaction with aryl iodides, bromides, and triflates to give aryl sulfoxides.
ChemInform Abstract: Tetrabutylammonium Iodide‐Catalyzed Oxidative Coupling of Enamides with Sulfonylhydrazides: Synthesis of β‐Keto‐Sulfones.
Authors: Tang Yucai , Zhang Ye , Wang Kaifeng , Li Xiaoqing , Xu Xiangsheng , Du Xiaohua 
Published: October 2015

AbstractA novel protocol for the catalyst‐ and base‐free synthesis of pharmaceutically interesting β‐keto sulfones is developed.
ChemInform Abstract: FeCl3 Mediated Synthesis of Substituted Indenones by a Formal [2 + 2] Cycloaddition/ring Opening Cascade of o‐Keto‐Cinnamates.
Authors: Dethe Dattatraya H. , Murhade Ganesh M. 
Published: October 2015

AbstractThe reaction tolerates a broad range of functional groups including halogen, amide, acid, and ester groups as well as aryl and hetaryl substituents.
ChemInform Abstract: Gold‐Catalyzed Cascade Cyclization of 2‐Alkynyl‐N‐Propargylanilines by Rearrangement of a Propargyl Group.
Authors: Tokimizu Yusuke , Oishi Shinya , Fujii Nobutaka , Ohno Hiroaki 
Published: October 2015

AbstractThe key feature of the construction of tetracyclic fused indolines is the migration of a propargyl substituent from an aniline nitrogen atom to the C‐3 position of an indole from 2‐alkynyl‐N‐propargylanilines.
ChemInform Abstract: Catalytic Asymmetric Desymmetrization of N‐Arylmaleimides: Efficient Construction of Both Atom Chirality and Axial Chirality.
Authors: Zhang Jianlin , Zhang Yulong , Lin Lili , Yao Qian , Liu Xiaohua , Feng Xiaoming 
Published: October 2015

AbstractThe catalytic asymmetric Michael addition/desymmetrization reaction of N‐(2‐t‐butylphenyl)maleimides with unprotected 3‐substituted‐2‐oxindoles is successfully realized using a chiral N,N′‐dioxide‐Sc(III) complex, leading to succinimides with two kinds of stereogenic elements: atom chirality and axial chirality.
ChemInform Abstract: CoCl2·6H2O‐Promoted Pinner—Dimroth Tandem Reaction: Facile Synthesis of 3‐Substituted Isoindolinones
Authors: Shi Daxin , Li Jiarong , Liu Mingxing , Zhang Qi 
Published: October 2015

Abstractby reaction of 2‐cyanobenzaldehyde with 1,3‐dicarbonyl compounds
ChemInform Abstract: Catalytic Enantioselective Ring‐Opening and Ring‐Closing Reactions of 3‐Isothiocyanato Oxindoles and N‐(2‐Picolinoyl)aziridines.
Authors: Wang Linqing , Yang Dongxu , Li Dan , Wang Rui 
Published: October 2015

AbstractFor the first time, an asymmetric formal [3 + 3] cycloaddition reaction between 3‐isothiocyanato oxindoles and aziridines is reported.
ChemInform Abstract: Gold‐Catalyzed Cycloisomerization and Diels—Alder Reaction of 1,4,9‐Dienyne Esters to 3a,6‐Methanoisoindole Esters with Pro‐Inflammatory Cytokine Antagonist Activity.
Authors: Susanti Dewi , Liu Li‐Juan , Rao Weidong , Lin Sheng , Ma Dik‐Lung , Leung Chung‐Hang , Chan Philip Wai Hong 
Published: October 2015

AbstractThe gold‐catalyzed tandem 1,2‐acetyloxy migration / Nazarov cyclization followed by Diels—Alder reaction of dienynes gives rise to desired 3a,6‐methanoisoindole esters (II) and (IV).
ChemInform Abstract: The Intramolecular Diels—Alder Vinylfuran (IMDAV) Reaction: A Short Approach To Aza‐Analogues of Pinguisane‐Type Sesquiterpenes.
Authors: Zubkov Fedor I. , et al.  
Published: October 2015

AbstractA domino sequence involving acylation of amines (I) with maleic anhydride, intramolecular Diels—Alder reaction, and proton shift steps provides the title compounds as single diastereoisomers.
ChemInform Abstract: Recyclable Bifunctional Polystyrene and Silica Gel‐Supported Organocatalyst for the Coupling of CO2 with Epoxides.
Authors: Kohrt Christina , Werner Thomas 
Published: October 2015

AbstractDioxolanones are prepared by coupling of CO2 with epoxides using silica‐ and polystyrene‐supported catalysts, respectively.
ChemInform Abstract: Direct Annulation of Hydrazides to 1,3,4‐Oxadiazoles via Oxidative C(CO)—C(Methyl) Bond Cleavage of Methyl Ketones.
Authors: Gao Qinghe , Liu Shan , Wu Xia , Zhang Jingjing , Wu Anxin 
Published: October 2015

AbstractAryl or hetaryl methyl ketones react with aryl or hetaryl hydrazides to efficiently form 2‐substituted 1,3,4‐oxadiazoles.
ChemInform Abstract: Enantioselective Synthesis of Functionalized 2‐Amino‐4H‐chromenes via the O‐Quinone Methides Generated from 2‐(1‐Tosylalkyl)phenols.
Authors: Wu Bo , Gao Xiang , Yan Zhong , Huang Wen‐Xue , Zhou Yong‐Gui 
Published: October 2015

AbstractMichael addition/cyclization reaction of o‐quinone methides generated in situ from substrates (I) and (VI) with active methylene compounds gives chromene derivatives in excellent yields with high enantioselectivities.
ChemInform Abstract: Regioselective Tandem [4 + 1]—[4 + 2] Synthesis of Amino‐Substituted Dihydroxanthones and Xanthones.
Authors: Bornadiego Ana , Diaz Jesus , Marcos Carlos F. 
Published: October 2015

AbstractThe tandem reaction between 3‐ketochromones (I), isocyanides (III) and vinyl methyl ketone (II) or acrylonitrile (V) gives the dihydroxanthones in good to high yields.
ChemInform Abstract: Synthesis of Novel Amide Functionalized 2H‐Chromene Derivatives by Ritter Amidation of Primary Alcohol Using HBF4·OEt2 as a Mild and Versatile Reagent and Evaluation of Their Antimicrobial and anti‐Biofilm Activities.
Authors: Ratnakar Reddy K. , Poornachandra Y. , Jitender Dev G. , Mallareddy G. , Nanubolu Jagadeesh B. , Kumar C. Ganesh , Narsaiah B. 
Published: October 2015

AbstractAmong all the tested compounds (IV), derivative (IVe) appears to be the most potent sample with respect to antimicrobial, MBC and anti bio‐film activities.
ChemInform Abstract: Copper(II)/Amine Synergistically Catalyzed Enantioselective Alkylation of Cyclic N‐Acyl Hemiaminals with Aldehydes.
Authors: Sun Shutao , Mao Ying , Lou Hongxiang , Liu Lei 
Published: October 2015

AbstractAn efficient catalytic system is found for the enantioselective alkylation of N‐acyl dihydroquinolines (I) and tetrahydroisoquinoline (VIII) with aldehydes.
ChemInform Abstract: Annulated N‐Heterocycles by Tandem Gold(I)‐Catalyzed [3,3]‐Rearrangement/Nazarov Reaction of Propargylic Ester Derivatives: An Experimental and Computational Study.
Authors: Petrovic Martina , Scarpi Dina , Fiser Bela , Gomez‐Bengoa Enrique , Occhiato Ernesto G. 
Published: October 2015

AbstractThis rearrangement generates a divinyl cation which undergoes a 4π electrocyclization leading to the target cyclopenta‐fused N‐heterocycles.The influence of the reaction conditions and the structure of the substrates on the reaction rate, regio‐ and stereoselectivity is also investigated.
ChemInform Abstract: Indolizine Synthesis via Oxidative Cross‐Coupling/Cyclization of Alkenes and 2‐(Pyridin‐2‐yl)acetate Derivatives.
Authors: Liu Ren‐Rong , Hong Jian‐Jun , Lu Chuan‐Jun , Xu Meng , Gao Jian‐Rong , Jia Yi‐Xia 
Published: October 2015

AbstractA novel access to various indolizines via copper/I2‐mediated oxidative cross‐coupling/cyclization of 2‐(pyridin‐2‐yl)acetate derivatives and simple olefins is given.
ChemInform Abstract: Synthesis of Indolo[1,2‐a][1,8]naphthyridines by Rhodium(III)‐Catalyzed Dehydrogenative Coupling via Rollover Cyclometalation.
Authors: Morioka Ryosuke , Nobushige Kazunori , Satoh Tetsuya , Hirano Koji , Miura Masahiro 
Published: October 2015

AbstractMost of the π‐conjugated products exhibit intense solid‐state fluorescence.
ChemInform Abstract: Copper‐Catalyzed Oxy‐Alkenylation of Homoallylic Alcohols to Generate Functional syn‐1,3‐Diol Derivatives.
Authors: Holt Dean , Gaunt Matthew J. 
Published: October 2015

AbstractA novel approach for the synthesis of various functionalized syn‐1,3‐diol derivatives involving the combination of readily available substituted homoallylic alcohol derivatives and alkenyl(aryl) iodinium salts is presented.
ChemInform Abstract: A One‐Pot Copper(II)‐Catalyzed Tandem Synthesis of 2‐Substituted Pyrrolo[1,2‐b]pyridazin‐4(1H)‐ones.
Authors: Tan Cun , Xiang Haoyue , He Qian , Yang Chunhao 
Published: October 2015

AbstractVarious aryl‐substituted oxo esters are treated with pyrrole (II) and analogues (VII) to produce the desired heterocyclic scaffold under conditions A).
ChemInform Abstract: Dy/Chitosan: A Highly Efficient and Recyclable Heterogeneous Nano Catalyst for the Synthesis of Hexahydropyrimidines in Aqueous Media.
Authors: Ahmed Nayeem , Tarannum Saima , Siddiqui Zeba N. 
Published: October 2015

AbstractThe applied catalyst is prepared in one step from dysprosium(III) nitrate and chitosan.
ChemInform Abstract: New Synthetic Approach Leading to 1‐ or 1,3‐Disubstituted 2‐Thiouracil‐5‐carboxylates via Dimroth Rearrangement of Isomeric Thiazines.
Authors: Hanusek Jiri , Hladikova Veronika , Kammel Richard 
Published: October 2015

AbstractCyclization of isothiuronium salts (III) affords the corresponding 2‐iminothiazines, which are unstable under basic conditions and immediately undergo a nucleophile‐assisted Dimroth rearrangement to 2‐thiouracils (IV).
ChemInform Abstract: Tetrahydro‐1,3‐oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation.
Authors: Skvorcova Marija , Grigorjeva Liene , Jirgensons Aigars 
Published: October 2015

AbstractThe transformation of cyclopropyl‐group containing bis‐imidates to cyclopropylmethyl cations followed by an intramolecular regioselective amination of the latter is described.
ChemInform Abstract: Synthesis and Characterization of Oxadisilole‐Fused Phenanthridines and Dioxatrisilole‐Fused Phenanthridines from Benzyne.
Authors: Chen Jingda , Chen Yali , Wang Xueli , Kong Kundi , Cao Weiguo , Chen Jie 
Published: October 2015

AbstractThe title phenanthridines are obtained by aza Diels—Alder reactions and dehydrogenation aromatization reactions of in situ generated benzyne with N‐benzylideneanilines.
ChemInform Abstract: Stereo‐ and Regioselective Formation of Silyl‐Dienyl Boronates.
Authors: Kaminsky Lauren , Wilson Robert J. , Clark Daniel A. 
Published: October 2015

AbstractThe formation of silyl‐dienyl boronates by intramolecular trans‐silylruthenation of internal alkynes and subsequent insertion of a vinyl boronate is demonstrated.
ChemInform Abstract: The β‐Silyl Effect on the Memory of Chirality in Friedel—Crafts Alkylation Using Chiral α‐Aryl Alcohols.
Authors: Nokami Toshiki , Yamane Yu , Oshitani Shunsuke , Kobayashi Jun‐ka , Matsui Shin‐ichiro , Nishihara Takashi , Uno Hidemitsu , Hayase Shuichi , Itoh Toshiyuki 
Published: October 2015

AbstractIt is found that the retention of the configuration of the hydroxyl group as a leaving group bases on the conformational stability of the carbocation intermediate supported by a flexible silyl substituent.
ChemInform Abstract: 10β‐Acetoxy‐8α,9α‐epoxy‐14β‐hydroxy‐7‐oxodolastane — A New Diterpene Isolated from the Brazilian Brown Macroalga Canistrocarpus cervicornis
Authors: Bianco Everson Miguel , Martins Francisco Thiago , Basilio Pinheiro Carlos , Bagueira de Vasconcellos Azeredo R. , Teixeira Valeria Laneuville , Pereira Renato Crespo 
Published: October 2015

Abstractisolation and structure elucidation of (I)
ChemInform Abstract: New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species
Authors: Yang Bin , Huang Jingxia , Lin Xiuping , Liao Shengrong , Zhou Xuefeng , Liu Juan , Wang Junfeng , Wang Lishu , Liu Yonghong 
Published: October 2015

Abstractisolation and structure elucudation of sinularcasbanes G—L (I‐VI)
ChemInform Abstract: A New N‐Glucosylated Indole Alkaloid and a New O‐Serine Glycoside from Berberis koreana.
Authors: Lee Kang Ro , Kim Ki Hyun , Moon Eunjung , Choi Sang Un , Kang Ki Sung , Kim Sun Yeou , Kang Hee Rae 
Published: October 2015

AbstractBoth compounds (I) and (II) reduce the nitric oxide production in lipopolysaccharide‐activated BV‐2 cells.
ChemInform Abstract: Synthesis of Polyhydroxylated Azetidine Iminosugars and 3‐Hydroxy‐N‐methylazetidine‐2‐carboxylic Acid from D‐Glucose.
Authors: Lawande Pravin P. , Sontakke Vyankat A. , Nair Roopa J. , Khan Ayesha , Sabharwal Sushma G. , Shinde Vaishali S. 
Published: October 2015

AbstractThe enantiopure title azetidines are synthesized utilizing an intramolecular Mitsunobu reaction as key step.
ChemInform Abstract: Glycosmisines A and B: Isolation of Two New Carbazole—Indole‐Type Dimeric Alkaloids from Glycosmis pentaphylla and an Evaluation of Their Antiproliferative Activities.
Authors: Chen Yu , Tang Chu , Wu Yi , Mo Shasha , Wang Sha , Yang Guangzhong , Mei Zhinan 
Published: October 2015

AbstractBiological tests reveal significant cytotoxicity and an apoptosis inducing effect of the newly isolated compounds (I) and (II).
ChemInform Abstract: A Carbohydrate Approach for the First Total Synthesis of Cochliomycin C (I): Stereoselective Total Synthesis of Paecilomycin E, Paecilomycin F and 6′‐epi‐Cochliomycin C.
Authors: Mahankali Bakkolla , Srihari Pabbaraja 
Published: October 2015

AbstractStarting from readily available sugar D‐lyxose, a unique strategy for the total synthesis of natural resorcylic acid lactones involving an Ohira—Bestmann alkynylation, ring closing metathesis, and regioselective methylation under Mitsunobu conditions as key steps is accomplished.
ChemInform Abstract: Recent Developments Regarding the Use of Thieno[2,3‐d]pyrimidin‐4‐one Derivatives in Medicinal Chemistry, with a Focus on Their Synthesis and Anticancer Properties
Authors: Bozorov Khurshed , Zhao Jiang‐Yu , Elmuradov Burkhon , Pataer Apar , Aisa Haji A. 
Published: October 2015

AbstractReview: 91 refs.
ChemInform Abstract: Investigation of the Cleanliness of Transferred Graphene: The First Step Toward Its Application as a Window Material for Electron Microscopy and Spectroscopy
Authors: Ma Tao , Miyazaki Kotaro , Ariga Hiroko , Takakusagi Satoru , Asakura Kiyotaka 
Published: October 2015

AbstractReview: 48 refs.
Efficacy of electrical stimulation and exercise for dysphagia in patients with head and neck cancer: A randomized clinical trial
Authors: Langmore Susan E. , McCulloch Timothy M. , Krisciunas Gintas P. , Lazarus Cathy L. , Van Daele Douglas J. , Pauloski Barbara Roa , Rybin Denis , Doros Gheorghe 
Published: October 2015

AbstractBackgroundNeuromuscular electrical stimulation (NMES) is a highly sought after but poorly studied treatment for dysphagia among patients with head and neck cancer with dysphagia. This study investigated the efficacy of NMES in this patient population.MethodsIn this double‐blinded, randomized controlled trial, 170 patients with head and neck cancer experiencing posttreatment dysphagia were randomized into active NMES + swallow exercise versus sham NMES + swallow exercise groups. Outcomes after a 12‐week program included changes in fluoroscopy measures, diet, and quality of life.ResultsAfter the 12‐week program, the active NMES group had significantly worse Penetration Aspiration Scale scores than the sham group. Both groups reported significantly better diet and quality of life. No other measures were significant.ConclusionNMES did not add benefit to traditional swallow exercises. Unfortunately, swallow exercises were not effective by themselves either. For patients with head and neck cancer with moderate to severe dysphagia caused by radiation therapy, current behavioral therapies are of limited help in reversing long‐term dysphagia. © 2015 Wiley Periodicals,Head Neck38: E1221–E1231, 2016
Effect of Column Type on Polyolefin Fractionation by High‐Temperature Thermal Gradient Interaction Chromatography
Authors: Al‐Khazaal Abdulaal Z. , Soares João B. P. 
Published: October 2015

SummaryHigh‐temperature thermal gradient interaction chromatography (HT‐TGIC) can be used to measure the chemical composition distribution (CCD) of semi‐crystalline and amorphous polyolefins. HT‐TGIC extends the range of polyolefin chemical compositions that can be measured today with crystallization‐based techniques. Hypercarb® columns packed with porous graphitic carbon are commonly used as the stationary phase in HT‐TGIC fractionation. We used a set of ethylene/1‐octene copolymers having different comonomer fractions (up to 25% of 1‐octene) and approximately the same molecular weight average to investigate how commercial Hypercarb® columns with distinct lengths and particle sizes affected HT‐TGIC fractionation. Binary copolymer blends were also analyzed to study how different blend compositions affected HT‐TGIC peak positions and shapes.
Activation of a Bis‐(Phenoxyimine) Titanium (IV) Catalyst Using Different Aluminoxane Co‐Catalysts
Authors: Romano Dario , Ronca Sara , Rastogi Sanjay 
Published: October 2015

SummaryThe activation of a bis‐phenoxyimine catalyst based on titanium (IV) using different aluminoxanes (MAO, PMAO and MMAO12) has been studied. The effect of a co‐catalyst modifier (BHT) used in combination with the MAO has been also tested. In particular, the effect of the activation time between the catalyst and the different aluminoxanes has been taken into consideration. On increasing the activation time between catalyst and the different aluminoxanes and TMA‐free MAO, differences in the catalyst activities have been observed. UHMWPEs having a reduced number of entanglements have been synthesized activating the FI catalyst with MAO and TMA‐free MAO. The obtained reactor powders can be solid‐state processed below the melting temperature in order to obtain high modulus/high tenacity tapes used for body armor and vehicle protection applications.
Development of Bimodality Criterion for the Sequence Length Distribution of Ethylene/1‐Olefin Copolymers
Authors: Anantawaraskul Siripon 
Published: October 2015

SummaryCombination of two single‐site‐type metallocene catalysts can be used to produce polymers with well‐defined, broad microstructural distributions. Copolymers with unimodal and bimodal microstructural distributions were known to have distinct properties; therefore, it would be useful for the product development to have bimodality criterion for these microstructural distributions. In this work, a bimodality criterion for ethylene sequence length distribution (SLD) of ethylene/1‐olefin copolymers produced with two metallocene catalysts was theoretically developed to predict if a given combination of two metallocene catalysts would produce copolymers with bimodal or unimodal SLD. The proposed criterion was validated using simulation data of four hypothetical ethylene/1‐olefin copolymer blends, each with various compositional ratios. The characteristics of simulated SLD results were in a good agreement with the predictions from the proposed criterion.
Sleep aspects on video‐polysomnography in LRRK2 mutation carriers
Authors: Ehrminger Mickael , Leu‐Semenescu Smaranda , Cormier Florence , Corvol Jean‐Christophe , Vidailhet Marie , Debellemaniere Eden , Brice Alexis , Arnulf Isabelle 
Published: October 2015

AbstractBackgroundRapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine‐rich repeat kinase 2 mutations is unknown.MethodsTen patients with leucine‐rich repeat kinase 2‐associated PD, four healthy leucine‐rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video‐polysomnography.ResultsNo sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine‐rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine‐rich repeat kinase 2–associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.ConclusionsThe sleep phenotype in leucine‐rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages. © 2015 International Parkinson and Movement Disorder Society