bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of body mass index on the prognosis of children and adolescents with high‐grade mature B‐cell non‐Hodgkin lymphoma
Authors: Zeng Chenggong , Wei Zhiqing , Huang Junting , Zhu Jia , Sun Feifei , Wang Juan , Lu Suying , Zhang Yizhuo , Sun Xiaofei , Zhen Zijun 
Published: August 2024

AbstractBackgroundLittle progress has been made in determining the prognostic factors for children and adolescents with high‐grade mature B‐cell non‐Hodgkin lymphoma (HG B‐NHL). Based on the important role of body mass index (BMI) in cancer, this study explored the effect of BMI on the prognosis of patients with HG B‐NHL.MethodsPatients aged <18 years with newly diagnosed HG B‐NHL were enrolled. Patients were divided into normal, overweight, obese, and emaciated BMI groups according to the growth criteria for children and adolescents.ResultsIn total, 435 patients were enrolled in this study. There were 329 (75.6%), 46 (10.6%), 13 (3.0%), and 47 (10.8%) patients stratified into the normal, overweight, obese, and emaciated BMI groups, respectively. The event‐free survival and overall survival rates of the entire cohort were 89.3% and 92.4%, respectively. The 5‐year event‐free survival rate for the patients with obese BMI was worse than those with overweight BMI (76.2% vs. 95.6%, p = .04). The 5‐year overall survival rate for the patients with emaciated BMI was worse than those with normal (84.5% vs. 93.1%, p = .04) or overweight BMI (84.5% vs. 97.7%, p = .03). Cox multivariate analysis showed that obese or emaciated BMI at diagnosis was associated with an increased risk of death (p = 0.04; HR, 2.26) and was identified as an independent adverse prognostic factor in pediatric HG B‐NHL.ConclusionObese or emaciated BMI at diagnosis is associated with poor prognosis in pediatric HG B‐NHL and can be used for risk stratification.
Revolutionizing Construction: Harnessing Phosphorus Tailings for Lightweight, High‐Strength Wall Materials
Authors: Wang Haiyang , Zhang Hao , Cao Hong , Xue Jun , Arramel  , Zou Jing , Jiang Jizhou 
Published: August 2024

AbstractThe beneficiation of low‐grade phosphate ore leads to the production of a substantial quantity of phosphate tailings, thereby not only occupying land but also endangering the environment and potentially posing safety concerns. In this work, extrusion molding, steam‐curing, and calcined phosphate tailings are employed to fabricate lightweight wall materials with superior strength. It is found that the wall material has a special structure of interwoven needle‐like crystals as a way to provide high flexural strength. The main composition of 34.94% phosphate tailings, 36.75% calcined phosphate tailings, 16.64% silica fume, 6.67% anhydrous magnesium sulfate is required to achieve an optimal maintenance process for 4 h of heat preservation at 120 °C saturated vapor pressure environment. The prepared wall materials yield a flexural strength of 24.9 MPa, compressive strength of 18.9 MPa, softening coefficient of 0.81, apparent density of 1.594 g cm−3, and thermal conductivity of 0.269 w/(m K), which meet the requirements of the Chinese standard “Lightweight strip board for building partition walls”. Moreover, the calculation revealed that phosphate tailings have a comprehensive utilization rate of 77.23%, effectively mitigating the issues arising from their accumulation and serving as an efficient means of utilizing solid waste derived from phosphate tailings.
PUS7‐dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression
Authors: Chang Yongxia , Jin Hao , Cui Yun , Yang Feng , Chen Kanghua , Kuang Wenjun , Huo Chunxiao , Xu Zhangqi , Li Ya , Lin Aifu , Yang Bo , Liu Wei , Xie Shanshan , Zhou Tianhua 
Published: August 2024

AbstractBackgroundRNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions. Despite its significance, the role of mRNA pseudouridylation in cancer remains poorly understood. This study investigates the impact of pseudouridine synthase 7 (PUS7)‐mediated pseudouridylation of Alpha‐ketoglutarate‐dependent Dioxygenase alkB Homolog 3 (ALKBH3) mRNA in gastric cancer.MethodsImmunohistochemistry and Western blotting were used to assess PUS7 protein levels in human gastric cancer tissues. The relationship between PUS7 and gastric cancer progression was examined using 3D colony formation assays and subcutaneous xenograft models. Real‐time quantitative PCR (RT‐qPCR), Western blotting, and polysome profiling assays were conducted to investigate how PUS7 regulates ALKBH3. A locus‐specific pseudouridine (Ψ) detection assay was used to identify Ψ sites on ALKBH3 mRNA.ResultsOur findings indicate a significant reduction of PUS7 in gastric cancer tissues compared to adjacent non‐tumour tissues. Functional analyses reveal that PUS7 inhibits gastric cancer cell proliferation and tumour growth via its catalytic activity. Additionally, PUS7 enhances the translation efficiency of ALKBH3 mRNA by modifying the U696 site with pseudouridine, thereby attenuating tumour growth. Importantly, ALKBH3 functions as a tumour suppressor in gastric cancer, with its expression closely correlated with PUS7 levels in tumour tissues.ConclusionsPUS7‐dependent pseudouridylation of ALKBH3 mRNA enhances its translation, thereby suppressing gastric cancer progression. These findings highlight the potential significance of mRNA pseudouridylation in cancer biology and suggest a therapeutic target for gastric cancer.Highlights
PUS7 enhances the translation efficiency of ALKBH3 through its pseudouridylation activity on ALKBH3 mRNA, thereby inhibiting gastric tumourigenesis.
The expression levels of PUS7 and ALKBH3 are significantly correlated in gastric tumours, which may be potential prognostic predictors and therapeutic targets for patients with gastric cancer.
Gut microbial changes in a specialist blister beetle larvae and their nutritional metabolic characteristics
Authors: Ma Jinnan , Fu Zhaohui , Yang Xin , Ming Wenqin , Song Xuhao , Du Chao 
Published: August 2024

AbstractInsect gut microbiota and their metabolites play a significant role in the shaping of hosts' diets and feeding habits. We conducted 16S rDNA amplicon sequencing on the gut microbiota of specialist blister beetle larvae that feed on locust eggs and artificial food at different instars, to explore the relationship between gut microbiota and the specialized feeding habit of the blister beetle larvae. There is no significant difference in the gut microbial structure among the second to the fourth instar larvae under the same rearing conditions, but the gut microbial structure of the first instar larvae was significantly different from the second to the fourth instar larvae fed by different diets. Bacteria associated with polysaccharide utilization are relatively barren in first instar larvae. Compared to the carbohydrate content between the artificial diet and locust eggs, we speculate that an excessive amount of polysaccharides in the artificial diet may be detrimental to the growth and development of first instar larvae. Gut microbiota of the second to the fourth instar larvae fed with different diets significantly differ in microbial community structure. The different bacteria, especially the metabolism‐related intestinal bacteria in locust eggs‐fed larvae, may help the hosts adapt to the environment and contribute to the production of active ingredients. The relative abundance of polysaccharide utilization‐related bacteria was significantly higher in the artificial diet‐fed larvae compared to the locust eggs‐fed larvae, which showed the same result when compared to the first instar larvae. Changes in gut microbes of blister beetle larvae and their metabolic inferences could enrich our understanding of the nutritional requirements of the specialist and help optimize the artificial diet of medicinal cantharides.
Does pain influence control of muscle force? A systematic review and meta‐analysis
Authors: Arvanitidis Michail , Falla Deborah , Sanderson Andy , Martinez‐Valdes Eduardo 
Published: August 2024

AbstractBackground and ObjectiveIn the presence of pain, whether clinical or experimentally induced, individuals commonly show impairments in the control of muscle force (commonly known as force steadiness). In this systematic review and meta‐analysis, we synthesized the available evidence on the influence of clinical and experimental pain on force steadiness.Databases and Data TreatmentMEDLINE, EMBASE, PubMed, CINAHL Plus and Web of Science databases were searched from their inception to 19 December 2023, using MeSH terms and pre‐selected keywords related to pain and force steadiness. Two independent reviewers screened studies for inclusion and assessed their methodological quality using a modified Newcastle–Ottawa risk of bias tool.ResultsIn total, 32 studies (19 clinical pain and 13 experimental pain) were included. Meta‐analyses revealed reduced force steadiness in the presence of clinical pain as measured by the coefficient of variation (CoV) and standard deviation (SD) of force (standardized mean difference; SMD = 0.80, 95% CI = 0.31–1.28 and SMD = 0.61, 95% CI = 0.11–1.11). These findings were supported by moderate and low strength of evidence respectively. In the presence of experimental pain, meta‐analyses revealed reductions in force steadiness when measured by the CoV of force but not by the SD of force (SMD = 0.50, 95% CI = 0.01–0.99; and SMD = 0.44, 95% CI = −0.04 to 0.92), each supported by very low strength of evidence.ConclusionsThis work demonstrates that pain, particularly clinical pain, impairs force steadiness. Such impairments likely have clinical relevance and could become targets for treatment when managing people experiencing musculoskeletal pain.Significance StatementThis systematic review and meta‐analyses enhances our understanding of motor impairments observed in people experiencing musculoskeletal pain. It underscores the significance of incorporating force steadiness assessment when managing individuals experiencing musculoskeletal pain. Additionally, it suggests that future research should explore the potential benefits of force steadiness training in alleviating patients' symptoms and enhancing their functional performance. This could potentially lead to the development of innovative therapeutic approaches for individuals suffering from musculoskeletal pain.
Italian report on RARE epilepsies (i‐RARE): A consensus on multidisciplinarity
Authors: Riva Antonella , Coppola Antonietta , Bisulli Francesca , Verrotti Alberto , Bagnasco Irene , Elia Maurizio , Darra Francesca , Lattanzi Simona , Meletti Stefano , La Neve Angela , Di Gennaro Giancarlo , Brambilla Isabella , Santoro Katia , Prisco Tommaso , Macari Francesca , Gambardella Antonio , di Bonaventura Carlo , Balestrini Simona , Marini Carla , Pruna Dario , Capovilla Giuseppe , Specchio Nicola , Gobbi Giuseppe , Striano Pasquale ,   the iRARE Study Group
Published: August 2024

AbstractObjectiveRare and complex epilepsies encompass a diverse range of disorders characterized by seizures. We aimed to establish a consensus on key issues related to these conditions through collaboration among experienced neurologists, neuropediatricians, and patient advocacy representatives.MethodsEmploying a modified Delphi method, a scientific board comprising 20 physicians and 4 patient advocacy representatives synthesized existing literature with their expertise to formulate statements on contentious topics. A final 32‐member expert panel, representing diverse regions of Italy, validated these statements through a two‐round voting process, with consensus defined as an average score ≥7.ResultsSixteen statements reached a consensus, emphasizing the necessity for epidemiological studies to ascertain the true prevalence of rare epilepsies. Etiology emerged as a crucial factor influencing therapeutic strategies and outcome prediction, with particular concern regarding prolonged and tonic–clonic seizures. The importance of early implementation of specific drugs and non‐pharmacological interventions in the treatment algorithm for developmental and epileptic encephalopathies (DEEs) was underscored. Multidisciplinary care involving experts with diverse skills was deemed essential, emphasizing non‐seizure outcomes in adolescence and adulthood.SignificanceThis national consensus underscores the imperative for personalized, comprehensive, and multidisciplinary management of rare epilepsies/DEEs. It advocates for increased research, particularly in epidemiology and therapeutic approaches, to inform clinical decision‐making and healthcare policies, ultimately enhancing patients' outcomes.Plain Language SummaryThe modified Delphi method is broadly used to evaluate debated topics. In this work, we sought the consensus on integrated and social care in epilepsy management. Both representatives of high‐level epilepsy centers and patients' caregivers were directly involved.
A multi‐objective optimization metaheuristic hybrid technique for forecasting the electricity consumption of the UAE: A grey wolf approach
Authors: Karathanasopoulos Andreas , Lo Chia Chun , Sovan Mitra , Osman Mohamed , von Mettenheim Hans‐Jörg , Skander Slim 
Published: August 2024

AbstractBy implementing a multi‐objective optimization approach in forecasting, we introduce three optimization models grey wolf optimizer, genetic algorithm, and differential evolution algorithm combined with multilayer perceptron neural networks and support vector machines to predict electricity consumption in the UAE. The hybrid models' accuracy and efficiency were evaluated using various forecasting metrics. This study's contributions are threefold: it is the first to employ such a sophisticated hybrid approach, particularly using the recently introduced grey wolf optimizer, it compares optimization techniques with the established Pearson correlation‐based method for dimensionality reduction and it represents one of the most extensive macroeconomic forecasts in the UAE using multi‐objective heuristic hybrid optimization methods. Our findings indicate that the grey wolf optimizer significantly outperforms all other models, followed by the genetic algorithm.
Specification of the health production function and its behavioral implications
Authors: Bolin Kristian , Caputo Michael R. 
Published: August 2024

AbstractThe health production function of the canonical health‐capital model is generalized to allow the state of health to affect the total and marginal products of health investment. If the total and marginal products of health investment are nonincreasing functions of the state of health, then the solution of the generalized model is locally qualitatively identical to that of the canonical model. Moreover, and in contrast to the canonical model, the generalized model is able to rationalize the cycling of the state of health and health investment observed in some individuals. The necessary conditions on the health production function for cyclical behavior are identified as well.
Unsteady MHD viscous dissipative Kuvshinski fluid past an infinite vertical porous plate with radiation, Soret, and Joule heating effect
Authors: Khayer Saleem Jabed Al , Chakraborty Shyamanta 
Published: August 2024

AbstractThis paper scrutinizes the combined effect of radiation, Soret, Joule heating, and chemical reaction on an unsteady magnetohydrodynamic visco‐elastic (Kuvshiniski type) fluid flow over an infinite vertical moving plate. The viscous dissipation, heat source, thermal and solutal buoyancy forces are taken into account. The plate is assumed to be embedded in a porous media and a transverse magnetic field is applied to the stream. The nondimensional governing equations are solved analytically using perturbation techniques. The influences of various dimensionless parameters on fluid velocity, temperature and concentration profiles, as well as the skin‐friction, Nusselt number and Sherwood number are analyzed and discussed graphically. Also, the present results are compared with previous studies and is found to be in excellent agreement. It has been shown that rising Soret numbers cause velocity, temperature and concentration to rise. Further, a hike in visco‐elastic parameter leads to decrease in motion, temperature and concentration profile.
Practical estimation and use of natural background concentrations in surface waters for nickel in Europe
Authors: Wilson Iain , Peters Adam , Merrington Graham , Middleton Ellie , Schlekat Christian , Garman Emily 
Published: August 2024

Abstract
Estimates of ambient background concentrations in surface waters, referred to as natural background concentrations (NBCs) in European guidance documents, may be an important factor in determining whether a monitoring site meets the legally binding Environmental Quality Standard (EQS) when assessing naturally occurring substances. Here, we focus on utilizing routine regulatory surface water monitoring data to provide risk assessors and environmental practitioners with a transparent, implementable, repeatable, and resource-effective approach to estimate NBCs. The methodology does not use additional environmental sampling beyond that which is routine or require advanced statistical methods, or the incorporation of highly specialist, and not always readily accessible, local knowledge. It determines both whether a site is suitable for NBC assessment as well as the identification of suitable surrogate sites and local NBCs using 11 criteria: six for identifying if a site is suitable for NBC correction, and five for identifying suitable surrogate sites for local NBC values. The criteria consider both the extent of any EQS exceedance, after accounting for bioavailability in line with the European guidance and potential anthropogenic impacts at the site, and can be applied in a simple sequential procedure. The method has been applied to derive NBCs for nickel on three case-study countries—Cyprus, France, and Spain—to determine its useability and impact on compliance. The methodology presented addresses a gap in the current guidance regarding the practical and consistent implementation of NBCs and could be applied to other naturally occurring substances in an EQS or Water Quality Guideline compliance assessment process. Integr Environ Assess Manag 2024;20:2128–2141. © 2024 WCA Environment Ltd and NiPERA Inc. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Key Points
A methodology is presented utilizing routine regulatory surface water monitoring data to provide risk assessors and environmental practitioners with a transparent, implementable, repeatable, and resource-effective approach to estimate natural background concentrations (NBCs). The methodology determines both whether a site is suitable for NBC assessment as well as the identification of suitable surrogate sites and local NBCs using 11 criteria: six for identifying if a site is suitable for NBC correction, and five for identifying suitable surrogate sites for local NBC values. The method has been applied to derive NBCs for nickel on three case-study countries—Cyprus, France, and Spain—to determine its useability and impact on compliance.
Recurrent cervical cancer detection using DNA methylation markers in self‐collected samples from home
Authors: Schaafsma Mirte , van den Helder Rianne , Mom Constantijne H. , Steenbergen Renske D. M. , Bleeker Maaike C. G. , van Trommel Nienke E. 
Published: August 2024

AbstractEarly detection of recurrent cervical cancer is important to improve survival rates. The aim of this study was to explore the clinical performance of DNA methylation markers and high‐risk human papillomavirus (HPV) in cervicovaginal self‐samples and urine for the detection of recurrent cervical cancer. Cervical cancer patients without recurrence (n = 47) collected cervicovaginal self‐samples and urine pre‐ and posttreatment. Additionally, 20 patients with recurrent cervical cancer collected cervicovaginal self‐samples and urine at time of recurrence. All samples were self‐collected at home and tested for DNA methylation and high‐risk HPV DNA by PCR. In patients without recurrent cervical cancer, DNA methylation levels decreased 2‐years posttreatment compared to pretreatment in cervicovaginal self‐samples (p < .0001) and urine (p < .0001). DNA methylation positivity in cervicovaginal self‐samples was more frequently observed in patients with recurrence (77.8%) than in patients without recurrence 2‐years posttreatment (25.5%; p = .0004). Also in urine, DNA methylation positivity was more frequently observed in patients with recurrence (65%) compared to those without recurrence (35.6%; p = .038). Similarly, high‐risk HPV positivity in both cervicovaginal self‐samples and urine was more frequent (52.6% and 55%, respectively) in patients with recurrence compared to patients without recurrence (14.9% and 8.5%, respectively) (p = .004 and p = .0001). In conclusion, this study shows the potential of posttreatment monitoring of cervical cancer patients for recurrence by DNA methylation and high‐risk HPV testing in cervicovaginal and urine samples collected at home. The highest recurrence detection rate was achieved by DNA methylation testing in cervicovaginal self‐samples, detecting 77.8% of all recurrences and, specifically, 100% of the local recurrences.
Impact of respectful maternal care training of health care providers on satisfaction with birth experience in mothers undergoing normal vaginal birth: A prospective interventional study
Authors: Singh Meenakshi , Baruhee Shailley , Saxena Pikee 
Published: August 2024

AbstractObjectiveTo study the impact of respectful maternity care (RMC) training of health care providers on RMC and birth satisfaction in mothers undergoing normal vaginal birth.MethodsA prospective interventional study was performed comparing RMC and birth satisfaction in women undergoing vaginal births before and after RMC training of health care providers from November 2021 to March 2023 in a tertiary care center in India. Person‐centered maternity care (PCMC) and birth satisfaction scale‐revised (BSSR) scales were used to study women's RMC and birth satisfaction, respectively.ResultsA total of 100 women undergoing normal vaginal birth were enrolled in pre‐ and post‐intervention phases. The intervention was done through formal and onsite training of health care providers in RMC. The mean total PCMC scale score in the post‐training group demonstrated a remarkable increase to 51.95 ± 6.50, significantly higher than the pre‐training mean of 32.82 ± 8.47 (P < 0.0001). The mean ± SD of the BSSR scale total score in the post‐training group increased significantly to 27.17 ± 3.67, surpassing the pre‐training mean of 21.19 ± 5.48 (P < 0.0001).ConclusionThe study showed significant improvement in RMC and birth satisfaction score in the post‐training group thereby emphasizing the importance of RMC training of health care providers in the facility.
On the nature of ergastic substances in the seeds of some Nigerian Leguminosae – II
Authors: Gill L. S. , Olabanji G. O. , Husaini S. W. H. 
Published: August 2024

SummarySeeds of 49 species of Leguminosae from Nigeria were examined for the presence of starch grains, proteins and fats and oils. Out of 32 species of Papilionoideae, 23 species are devoid of starch. In Caesalpinoideae, the starch grains were determined only in two species and only one species of Mimosoideae was found to contain starch grains. The morphological characteristics of starch grains are given. In general, arborescent taxa lack starch grains.