bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning as Leaving Home: Fear, Empathy, and Hospitality in the Theology and Religion Classroom
Authors: Fleming Daniel , Lovat Terence 
Published: July 2015

AbstractThe article is a response to this journal's call for papers on metaphors for teaching, and also draws from a previous publication in which Kent Eilers developed a methodology for teaching global theologies. In this methodology, the ultimate goal was the development of “hermeneutical dispositions of empathy, hospitality, and receptivity toward culturally diverse voices” (2014, 165). This article considers the goals of Eilers' methodology, and others like his, and how it is that the metaphors of “leaving home” and “communal imagination” highlight the importance of the ambient and interpersonal features of a classroom and their effect on the attainment of the above goals. In so doing, it extends the conversation beyond content and methodology in teaching theology and religion into the realms of philosophy of education, as well as the fields of moral and values education. It is contended that the metaphors informed by these areas of study facilitate the attainment of such goals, and similar ones, by demonstrating that the cultivation of an ambience of care, trust, and compassion within the classroom constitutes an essential foundation for learning in which students “leave home” and cultivate “communal imagination.” The article finishes with practical suggestions for educators in theology and religion.
Teaching Religious Studies at the International Islamic University Malaysia
Authors: Kenney Jeffrey T. 
Published: July 2015

AbstractThis essay is part of a collection of short essays solicited from authors around the globe who teach religion courses at the college level (not for professional religious training). They are published together with an introduction in Teaching Theology and Religion 18:3 (July 2015). The authors were asked to provide a brief overview of the curriculum, student learning goals, and pedagogical techniques employed in their courses.
Teaching Church History in Global Perspective in New Zealand
Authors: Cooper Tim 
Published: July 2015

AbstractThis essay is part of a collection of short essays solicited from authors around the globe who teach religion courses at the college level (not for professional religious training). They are published together with an introduction in Teaching Theology and Religion 18:3 (July 2015). The authors were asked to provide a brief overview of the curriculum, student learning goals, and pedagogical techniques employed in their courses.
Student Learning in an Introductory GIS Course: Using a Project‐Based Approach
Authors: Bowlick Forrest J. , Bednarz Sarah W. , Goldberg Daniel W. 
Published: July 2015

AbstractIntroductory courses in Geographic Information Science (GIS) expose students to the concepts and practices necessary for future academic and professional use of GIS tools. Traditional GIS courses balance lectures in the theories of GIS with pre‐built and pre‐packaged lab activities to learn the practices of GIS. This article presents a case study of an experimental introductory course in which students conducted novel, independent project‐based group research under the supervision of graduate or advanced undergraduate students enrolled in the course, culminating in a class presentation and publication quality paper. Surveys and interviews indicated that students reacted more positively to project‐based group research than to traditional activities. Students felt the projects better prepared them for ‘real world’ applications of GIS, and recommend project‐based group research in other GIS coursework. Additionally, our findings indicate that students appreciate interactions with peers of varying skill levels and experiences, as these broaden their capabilities to work with other GIS users.
Functional characterization of mutants affected in the carbonic anhydrase domain of the respiratory complex I in Arabidopsis thaliana
Authors: Soto Débora , Córdoba Juan Pablo , Villarreal Fernando , Bartoli Carlos , Schmitz Jessica , Maurino Veronica G. , Braun Hans Peter , Pagnussat Gabriela C. , Zabaleta Eduardo 
Published: July 2015

SummaryThe NADH–ubiquinone oxidoreductase complex (complex I) (EC 1.6.5.3) is the main entrance site of electrons into the respiratory chain. In a variety of eukaryotic organisms, except animals and fungi (Opisthokonta), it contains an extra domain comprising trimers of putative γ–carbonic anhydrases, named the CA domain, which has been proposed to be essential for assembly of complex I. However, its physiological role in plants is not fully understood. Here, we report that Arabidopsis mutants defective in two CA subunits show an altered photorespiratory phenotype. Mutants grown in ambient air show growth retardation compared to wild–type plants, a feature that is reversed by cultivating plants in a high‐CO2 atmosphere. Moreover, under photorespiratory conditions, carbon assimilation is diminished and glycine accumulates, suggesting an imbalance with respect to photorespiration. Additionally, transcript levels of specific CA subunits are reduced in plants grown under non‐photorespiratory conditions. Taken together, these results suggest that the CA domain of plant complex I contributes to sustaining efficient photosynthesis under ambient (photorespiratory) conditions.
Analytic errors in Sysmex‐generated hematology results in blood from a dog with chronic lymphocytic leukemia
Authors: Novacco Marilisa , Martini Valeria , Grande Carmen , Comazzi Stefano 
Published: July 2015

AbstractA blood sample from a 14‐year‐old dog was submitted to the veterinary diagnostic laboratory of the University of Milan for marked leukocytosis with atypical cells. A diagnosis of chronic T‐cell lymphocytic leukemia (CLL) was made based on blood smear evaluation and flow cytometric phenotyping. ACBCby SysmexXT‐2000iV revealed a moderate normocytic normochromic anemia. Red blood cells counted by optic flow cytometry (RBC‐O) resulted in a higher value than using electrical impedance (RBC‐I). The relative reticulocyte count based onRNAcontent and size was 35.3%, while the manual reticulocyte count was < 1%. TheWBCcount of 1,562,680 cells/μL was accompanied by a flag. Manual counts forRBCandWBCusing the Bürker chamber confirmed the Sysmex impedance results. Finally the manualPCVwas lower thanHCTby Sysmex. While SysmexXTcan differentiate betweenRBCandWBCby impedance, even in the face of extreme lymphocytosis due toCLL,RBC‐O can be affected by bias, resulting in falsely increasedRBCand reticulocyte numbers. Overestimation ofRBC‐O may be due to incorrect Sysmex classification of leukemic cells or their fragments as reticulocytes. This phenomenon is known as pseudoreticulocytosis and can lead to misinterpretation of regenerative anemia. On the other sidePCVcan be affected by bias inCLLdue to the trapping ofRBCin the buffy coat, resulting in a pink hue in the separation area. AsHGBconcentration is not affected by flow cytometric or other cell‐related artifacts it may represent the most reliable variable to assess the degree of anemia in cases ofCLL.
Effectiveness of a combined (4% chlorhexidine digluconate shampoo and solution) protocol in MRS and non‐MRS canine superficial pyoderma: a randomized, blinded, antibiotic‐controlled study
Authors: Borio Stefano , Colombo Silvia , La Rosa Giuseppe , De Lucia Michela , Damborg Peter , Guardabassi Luca 
Published: July 2015

BackgroundThere is a lack of studies comparing topical antiseptics to systemic antibiotics in the treatment of canine superficial pyoderma.Hypothesis/ObjectivesTo compare the efficacy of topical chlorhexidine with systemic amoxicillin–clavulanic acid for the treatment of canine superficial pyoderma.AnimalsA randomized controlled trial was conducted in dogs with superficial pyoderma. Group T (n = 31) was treated topically with 4% chlorhexidine digluconate shampoo (twice weekly) and solution (once daily) for 4 weeks. Group S (n = 20) was treated orally with amoxicillin–clavulanic acid (25 mg/kg) twice daily for 4 weeks.MethodsBacterial culture and susceptibility testing were performed on clinical specimens collected before treatment. Severity of lesions and number of intracellular bacteria were evaluated using four‐point scales to calculate a total pyoderma score for each dog. Pruritus was assessed by owners using a visual analog scale (range 0–10). Scores were analysed for statistical differences between groups T and S.ResultsStaphylococcus pseudintermedius was isolated from 48 dogs, including eight meticillin‐resistant strains (MRSP). Although the number of dogs was small, no significant differences in pyoderma and pruritus scores were observed between groups throughout the study except for day 1, when group S had a significantly higher total score than group T (P = 0.03). Treatment with chlorhexidine products resulted in resolution of clinical signs in all dogs including those infected with MRSP.Conclusion and clinical importanceTopical therapy with chlorhexidine digluconate products may be as effective as systemic therapy with amoxicillin–clavulanic acid. This finding supports the current recommendations to use topical antiseptics alone for the management of superficial pyoderma.
Nucleolin enhances the proliferation and migration of heat‐denatured human dermal fibroblasts
Authors: Jiang Bimei , Li Yuanbin , Liang Pengfei , Liu Yanjuan , Huang Xu , Tong Zhongyi , Zhang Pihong , Huang Xiaoyuan , Liu Ying , Liu Zhenguo 
Published: July 2015

ABSTRACTDenatured dermis, a part of dermis in burned skin, has the ability to restore its normal morphology and functions after their surrounding microenvironment is improved. However, the cellular and molecular mechanisms by which the denatured dermis could improve wound healing are still unclear. This study aimed to investigate the role of nucleolin during the recovery of heat‐denatured human dermal fibroblasts. Nucleolin mRNA and protein expression were significantly increased time‐dependently during the recovery of heat‐denatured human dermal fibroblasts (52 °C, 30 seconds). Heat‐denaturation promoted a time‐dependent cell proliferation, migration, chemotaxis, and scratched wound healing during the recovery of human dermal fibroblasts. These effects were prevented by knockdown of nucleolin expression with small interference RNA (siRNA), whereas overexpression of nucleolin enhanced cell proliferation, migration, and chemotaxis of human dermal fibroblasts with heat‐denaturation. In addition, the expression of transforming growth factor‐beta 1(TGF‐β1) was significantly increased during the recovery of heat‐denatured dermis and human dermal fibroblasts. TGF‐β1 expression was up‐regulated by nucleolin in human dermal fibroblasts. The results suggest that nucleolin expression is up‐regulated, and play an important role in promoting cell proliferation, migration, and chemotaxis of human dermal fibroblasts during the recovery of heat‐denatured dermis with a mechanism probably related to TGF‐β1.
Advances in genetic therapeutic strategies for Duchenne muscular dystrophy
Authors: Guiraud Simon , Chen Huijia , Burns David T. , Davies Kay E. 
Published: July 2015

New Findings

What is the topic of this review?
This review highlights recent progress in genetically based therapies targeting the primary defect of Duchenne muscular dystrophy.

What advances does it highlight?
Over the last two decades, considerable progress has been made in understanding the mechanisms underlying Duchenne muscular dystrophy, leading to the development of genetic therapies. These include manipulation of the expression of the gene or related genes, the splicing of the gene and its translation, and replacement of the gene using viral approaches.

Duchenne muscular dystrophy is a lethal X‐linked disorder caused by mutations in the dystrophin gene. In the absence of the dystrophin protein, the link between the cytoskeleton and extracellular matrix is destroyed, and this severely compromises the strength, flexibility and stability of muscle fibres. The devastating consequence is progressive muscle wasting and premature death in Duchenne muscular dystrophy patients. There is currently no cure, and despite exhaustive palliative care, patients are restricted to a wheelchair by the age of 12 years and usually succumb to cardiac or respiratory complications in their late 20s. This review provides an update on the current genetically based therapies and clinical trials that target or compensate for the primary defect of this disease. These include dystrophin gene‐replacement strategies, genetic modification techniques to restore dystrophin expression, and modulation of the dystrophin homologue, utrophin, as a surrogate to re‐establish muscle function.
Arterial structure and function in vascular ageing: are you as old as your arteries?
Authors: Thijssen Dick H. J. , Carter Sophie E. , Green Daniel J. 
Published: July 2015

AbstractAdvancing age may be the most potent independent predictor of future cardiovascular events, a relationship that is not fully explained by time‐related changes in traditional cardiovascular risk factors. Since some arteries exhibit differential susceptibility to atherosclerosis, generalisations regarding the impact of ageing in humans may be overly simplistic, whereas in vivo assessment of arterial function and health provide direct insight. Coronary and peripheral (conduit, resistance and skin) arteries demonstrate a gradual, age‐related impairment in vascular function that is likely to be related to a reduction in endothelium‐derived nitric oxide bioavailability and/or increased production of vasoconstrictors (e.g. endothelin‐1). Increased exposure and impaired ability for defence mechanisms to resist oxidative stress and inflammation, but also cellular senescence processes, may contribute to age‐related changes in vascular function and health. Arteries also undergo structural changes as they age. Gradual thickening of the arterial wall, changes in wall content (i.e. less elastin, advanced glycation end‐products) and increase in conduit artery diameter are observed with older age and occur similarly in central and peripheral arteries. These changes in structure have important interactive effects on artery function, with increases in small and large arterial stiffness representing a characteristic change with older age. Importantly, direct measures of arterial function and structure predict future cardiovascular events, independent of age or other cardiovascular risk factors. Taken together, and given the differential susceptibility of arteries to atherosclerosis in humans, direct measurement of arterial function and health may help to distinguish between biological and chronological age‐related change in arterial health in humans.
Observation of phononic helical edge states in a mechanical topological insulator
Authors: Süsstrunk Roman , Huber Sebastian D. 
Published: July 2015

Designing mechanical complexity
The quantum properties of topological insulators translate to mechanical systems governed by Newton's equations of motion. Many-body interactions and the multiple degrees of freedom available to charge carriers give electronic systems a range of exotic behaviors. Süsstrunk and Huber show that this extends to mechanical systems made up of a large lattice of coupled pendula. Mechanical excitations can be eliminated from the inner part of the lattice and confined to the edges, much like topological insulators. In addition to presenting a tractable toy system in which to study complex phenomena, the approach has potential uses in vibration isolation.

Science
, this issue p.
47
Draft Genome Sequence of Picalivirus D Recovered from San Francisco Wastewater
Authors: Greninger Alexander L. , DeRisi Joseph L. 
Published: July 2015

ABSTRACT

We report here the draft genome sequence of picalivirus D, a member of picalivirus, a picorna-like superfamily, and likely member of the order
Picornavirales
, assembled from metagenomic sequencing of organisms in San Francisco wastewater. This virus likely constitutes a novel genus within the picalivirus family.
Complete Genomic Sequence of Issyk-Kul Virus
Authors: Atkinson Barry , Marston Denise A. , Ellis Richard J. , Fooks Anthony R. , Hewson Roger 
Published: July 2015

ABSTRACT

Issyk-Kul virus (ISKV) is an ungrouped virus tentatively assigned to the
Bunyaviridae
family and is associated with an acute febrile illness in several central Asian countries. Using next-generation sequencing technologies, we report here the full-genome sequence for this novel unclassified arboviral pathogen circulating in central Asia.
Complete Genome Sequence of Bacillus thuringiensis Serovar Tolworthi Strain Pasteur Institute Standard
Authors: Kanda Kohzo , Nakashima Kaede , Nagano Yukio 
Published: July 2015

ABSTRACT

The genome sequence of
Bacillus thuringiensis
serovar tolworthi strain Pasteur Institute Standard was determined. The genome consists of a 5.9-Mb chromosome and eight plasmids, one of which is linear. The second largest plasmid (293 kb) carries the genes encoding insecticidal proteins.
Whole-Genome Sequence of Multidrug-Resistant Staphylococcus caprae Strain 9557, Isolated from Cerebrospinal Fluid
Authors: Zheng Beiwen , Jiang Xiawei , Li Ang , Yao Jian , Zhang Jing , Hu Xinjun , Li Lanjuan 
Published: July 2015

ABSTRACT

Staphylococcus caprae
strain 9557 was isolated from a cerebrospinal fluid sample. The assembled genome contained 2,747,651-bp nucleotides with 33.34% GC content. Consistent with its phenotypic characteristics, the genome harbors a varying repertoire of putative virulence factors involved in invasion, survival, and growth in the host cells.
Draft Genome Sequence of Jiangella alkaliphila KCTC 19222
T
, Isolated from Cave Soil in Jeju, Republic of Korea
Authors: Jiao Jian-Yu , Liu Lan , Park Dong-Jin , Kim Chang-Jin , Xiao Min , Chen Jing , Li Li , Zhong Jing-Mei , Zhao Jiao , Li Wen-Jun 
Published: July 2015

ABSTRACT

We report the draft genome sequence of
Jiangella alkaliphila
KCTC 19222
T
, isolated from cave soil in Jeju, Republic of Korea. This genome sequence, together with the previously sequenced
J. gansuensis
strain DSM 44835
T
, identified from a desert environmental source, will give us a better understanding of the school of “evolutionary taxonomy.”
Draft Genome Sequences of Vibrio alginolyticus Strains V1 and V2, Opportunistic Marine Pathogens
Authors: Castillo Daniel , D’Alvise Paul , Kalatzis Panos G. , Kokkari Constantina , Middelboe Mathias , Gram Lone , Liu Siyang , Katharios Pantelis 
Published: July 2015

ABSTRACT

We announce the draft genome sequences of
Vibrio alginolyticus
strains V1 and V2, isolated from juvenile
Sparus aurata
and
Dentex dentex
, respectively, during outbreaks of vibriosis. The genome sequences are 5,257,950 bp with a G+C content of 44.5% for
V. alginolyticus
V1 and 5,068,299 bp with a G+C content of 44.8% for strain V2. These genomes provide further insights into the putative virulence factors, prophage carriage, and evolution of this opportunistic marine pathogen.
Using simplified peer review processes to fund research: a prospective study
Authors: Herbert Danielle L , Graves Nicholas , Clarke Philip , Barnett Adrian G 
Published: July 2015

ObjectiveTo prospectively test two simplified peer review processes, estimate the agreement between the simplified and official processes, and compare the costs of peer review.Design, participants and settingA prospective parallel study of Project Grant proposals submitted in 2013 to the National Health and Medical Research Council (NHMRC) of Australia. The official funding outcomes were compared with two simplified processes using proposals in Public Health and Basic Science. The two simplified processes were: panels of 7 reviewers who met face-to-face and reviewed only the nine-page research proposal and track record (simplified panel); and 2 reviewers who independently reviewed only the nine-page research proposal (journal panel). The official process used panels of 12 reviewers who met face-to-face and reviewed longer proposals of around 100 pages. We compared the funding outcomes of 72 proposals that were peer reviewed by the simplified and official processes.Main outcome measuresAgreement in funding outcomes; costs of peer review based on reviewers’ time and travel costs.ResultsThe agreement between the simplified and official panels (72%, 95% CI 61% to 82%), and the journal and official panels (74%, 62% to 83%), was just below the acceptable threshold of 75%. Using the simplified processes would save $A2.1–$A4.9 million per year in peer review costs.ConclusionsUsing shorter applications and simpler peer review processes gave reasonable agreement with the more complex official process. Simplified processes save time and money that could be reallocated to actual research. Funding agencies should consider streamlining their application processes.
Chronic Kidney Disease in Patients With Lacunar Stroke
Authors: Xiao Lulu , Lan Wenya , Sun Wen , Dai Qiliang , Xiong Yunyun , Li Ling , Zhou Yan , Zheng Ping , Fan Wenping , Ma Nan , Guo Zhiliang , Chen Xin , Xie Xia , Xu Lili , Zhu Wusheng , Xu Gelin , Liu Xinfeng 
Published: July 2015

Background and Purpose—
The relationship between chronic kidney disease and cerebral small vessel disease (cSVD), especially enlarged perivascular spaces (EPVS), has not been fully understood. This study aimed to investigate the association of chronic kidney disease and EPVS, as well as the total burden of cSVD on magnetic resonance imaging, expressed by the simultaneous presence of multiple markers of cSVD, among patients with first-ever lacunar stroke.

Methods—
Four hundred and thirteen consecutive patients were prospectively enrolled. Centrum semiovale and basal ganglia EPVS on T2-weighted magnetic resonance imaging, as well as other imaging markers of cSVD, including lacune, white matter lesions, and cerebral microbleeds, were rated using validated scales. Chronic kidney disease was defined as either reduced estimated glomerular filtration rate or the presence of proteinuria.

Results—
After adjustments for potential confounders by logistic regression, proteinuria and impaired estimated glomerular filtration rate were correlated with the severity of EPVS in both centrum semiovale (odds ratio [OR] 2.59; 95% confidence interval [CI] 1.19–5.64 and OR 2.37; 95% CI 1.19–4.73) and basal ganglia (OR 5.12; 95% CI 2.70–12.10 and OR 4.17; 95% CI 2.08–8.37). A similar association was also found between proteinuria and low estimated glomerular filtration rate levels and the comprehensive cSVD burden (OR 2.13; 95% CI 1.10–4.14 and OR 5.59; 95% CI 2.58–12.08).

Conclusions—
Proteinuria and impaired estimated glomerular filtration rate are associated with increasing EPVS severity and, furthermore, accumulated magnetic resonance imaging burden of cSVD in patients with first-ever acute lacunar stroke.