bluuebunny/crossref_metadata_2025_split huggingface dataset:
1770 – Pattern Of Tobacco Use And Psychopathology In Patients With Schizophrenia And Bipolar Disorder That Participated In Multicomponent Smoking Cessation Program
Authors: García-Álvarez L. , García-Portilla P. , Rico-Villademoros P. , Elizagarate E. , Ubis A. , Sarramea F. , Torres A. , Galván G. , Díaz-Mesa E. , Sáiz P. , Bobes J. 
Published: July 2013

IntroductionPeople with schizophrenia and bipolar disorder are more likely to smoke, smoke more cigarettes per day and have greater mortality from smoking-related disease than those in the general population.ObjectivesTo describe the sample and to identify the relationship between the pattern of tobacco use and psychopathology.MethodsMulticenter, observational, prospective, 12-month follow up study to assess the clinical efficacy of a multicomponent smoking cessation program specifically designed for patients with severe mental illness.Sample65 patients from 3 Mental Health Centers sited in Spain [64.6% males; mean age (SD) = 44.63 (8.93)].Instruments(1)Pattern of tobacco use: Fargerstrom Test for Nicotine physical Dependence; Glover-Nilsson Test for Nicotine psychological Dependence; expired carbon monoxide (CO); n° cigarettes/day; n° smoking years.(2)Psychopathology: PANSS; Hamilton; Young; CGI-G.ResultsSchizophrenia 64.6% and bipolar 26.2%; suicide attempts 36.9% (2.83 mean of suicide attemps); economically active 7.7%. There is no differences: in psychopatology severity between “heavy smokers” (ppm ≥ 26 or n° cigarettes/day ≥ 30) and “non heavy smokers” (ppm < 26 or n° cigarettes/day < 30) and in the pattern of tobacco use between schizophrenia and bipolar patients. There is no relationship between psychopatology severity and the pattern of tobacco use in schizophrenia patients. Finally, there is relationship between depressive symptoms (Hamilton) and nicotine psychological dependence (Glover-Nilsson Test) in bipolar disorder patients (r = 0.72, p = 0.004).ConclusionsIn bipolar disorder patients, there is relationship between the severity of depressive symptoms and the dependence of nicotine.
1775 – Economic Impact Of Antidepressant Treatment Duration In a Real-life Setting
Authors: Tournier M. , Crott R. , Gaudron Y. , Verdoux H. 
Published: July 2013

IntroductionThe benefit-risk ratio of a long duration of antidepressant drug treatment (ADT) may not be favourable. A pragmatic way to study the consequences of ADT duration in accordance with practice guidelines is to assess its impact on health care use.ObjectivesTo assess the economic impact of ADT duration in a real-life setting through the changes in direct health care costs.MethodA historical fixed cohort study included 27,134 patients aged 18 and over with a new ADT registered in the national insurance database. The economic impact concerned health care expenditure in the first three months after treatment discontinuation. Generalized linear models compared two groups of treatment duration: less than six months and six months and over.ResultsAfter adjustment for care costs before and during ADT, gender, age, chronic diseases, welfare entitlement and prescriber specialty, total health care costs (in log) [-0.06 (-0.14;0.01) p = 0.11] and psychiatric care costs (in square root) [-0.08 (-0.41;0.25) p = 0.6] were similar in both groups after ADT discontinuation. Non-psychiatric care costs were significantly lower in the “long treatment duration” group compared with the “short treatment duration” group [-11.4 (-15.8;-7.0) p < 0.0001]. The decreases in total and non-psychiatric care costs after the ADT episode were larger in the “long treatment duration” group compared with the “short treatment duration” group.ConclusionsWith regard to health care costs and global health, ADT of short duration appear less effective than treatment of recommended duration.
1779 – Spectral Analysis Of Cerebral Hemodynamics And Gender During Set Shifting And Set Maintenance
Authors: Pude I. , Boeker H. , Seifritz E. , Schuepbach D. 
Published: July 2013

IntroductionSet shifting provokes gender related alterations of rapid cerebral hemodynamics in large basal cerebral arteries. However, no information on frequency patterns has been reported, especially when comparing phases of set shifting and set maintenance.ObjectivesIn the following functional transcranial Doppler study (fTCD), we introduced spectral analysis to rapid cerebral hemodynamic changes.AimsTo investigate signal characteristics during both phases and its correlate with sociodemographic and performance variables.MethodsMale and female participants performed the Wisconsin Card Sorting Test during measurement of the middle cerebral arteries. Cerebral hemodynamics underwent spectral transformation during set maintenance and set shifting. Correlation analyses examined the linkage with sociodemographic and performance variables.ResultsScattering of frequencies was significantly increased during set shifting as compared to set maintenance (P = 0.006). Increasing age was significantly associated with increasing variability of spectral frequencies during set maintenance (P < 0.002). In males, but not in females, higher age predicted increased variability of spectral frequencies during set shifting on the right hemisphere (P = 0.002). During that phase, males showed a frequency peak near 0.1 Hz (trend level).ConclusionsThis study provides evidence that spectral analysis of cerebral hemodynamics is a fruitful strategy to characterize gender differences and brain behavior relationships during higher cognitive functioning. Further covariates such as age, performance and hemisphere have to be considered. In other words, signal frequency of cerebral hemodynamics may be an underreported neurobiological marker in addition to signal strength, with special relevance for psychiatric diseases with cognitive dysfunction and/or gender differences, such as schizophrenia or major depression.
1784 – The Characteristics Of Nicotine Addiction Among Patients With Schizophrenia
Authors: Wojtyna E. , Wiszniewicz A. 
Published: July 2013

IntroductionNicotine addiction is common among people with schizophrenia and is associated with significant morbidity and mortality. This rate is a much higher than among the general population, where the percentage of smokers varies between 25-47%.AimsThis study aims to characterize nicotine dependence in schizophrenics compared to smokers not having mental health problems. The research was also to determine whether the affective psychological factors (anxiety and depression) and the level of distress are important predictors of smoking in a group of psychotic patients.Methods204 smokers participated in the research, including 104 people with schizophrenia and 100 healthy persons. Participants were interviewed and asked to complete five questionnaires: Fagerström Test for Nicotine Dependence, Test of Motivation for Smoking Cessation, Hospital Anxiety and Depression Scale and Distress Thermometer.ResultsThe study has shown that the schizophrenics smoked more, took a greater number of puffs, showed a higher level of dependence and were less motivated to give up smoking than the mentally healthy persons. The results show the important role of affective factors and feeling of distress in nicotine dependence. The study also confirmed a significant relationship between distress and the number of cigarettes smoked. Affective factors and distress explain 34% of variance of the number of cigarettes in the group of schizophrenics and 56% in the control group.ConclusionsThis study showed that psychological treatment should be implemented into programs for nicotine dependence to improve the functioning schizophrenics in terms of coping with stress and maintaining good mood.
1787 – The Importance Of Gender Proofing Government Policy To Tackle Gender Mental Health Inequality
Authors: Datta A. , Frewen J. 
Published: July 2013

IntroductionThe ongoing global economic recession has impacted most severely on the more vulnerable sections of society. The policy of economic austerity being pursued by the British government - 2011-2012 saw the first decline in spending on mental health in 10 years - has placed further strain on the underprivileged.ObjectivesThis paper will examine the impact of the recession and British government policy on gender mental health inequality and recommend corrective action as appropriate.AimsExamine impact of recession and British government policy ona)negative social determinants of mental health of womenb)how they contribute to mental health inequity andc)what measures might be adopted to tackle these negative social determinants.Methods1/Analyse arguments on impact of social determinants on mental health inequities.2/Review available hardcopy and internet literature on recession and government policies as they pertain to women and mental health inequalities.3/Determine optimal approach on behalf of government to prevent gender mental health inequalities.ResultsCurrent British government policies risk adversely impacting upon the social determinants of mental health of women in Britain, with negative consequences in terms of gender mental health equity. This is particularly true for women in economically disadvantaged circumstances.ConclusionsUrgent action is required to address this situation bya)reversing policies that negatively impact upon women and risk provoking mental health inequalities andb)introducing gender-proofed policies that will not negatively impact upon the social determinants of mental health of women in Britain.
1789 – Learning Resource For Water Control To Enhance Hemodialysis Patients’ Complience
Authors: Martins J.P.L.B. , Biavo B.M.M. , Caramello S.R. , Rocha J.C. , Santos J.A.P.d. , Barros C.M.D. , Ribeiro E. , Silva T. , Martins C.T.B. 
Published: July 2013

BackgroundTwo parameters for assessment compliance in HD patients are interdialytic weight gain (IWG) and absences, both influenced by psychological and nutritional aspects.ObjectiveAchieve greater compliance by using Water Control Dynamic (Bucket Dynamic - BD) to clarify risks of excessive IWG.MethodBD was performed during HD session by nutritionist and psychologist in 48 HD patients to show that HD doesn’t eliminate fluids as a healthy kidney. Two buckets (B) are presented; one filled with water (B1) another empty (B2). Professional holds an 250 mL glass (represents fluids someone ingests), the other holds a 50 mL glass (represents HD fluid removal capacity). The 250 mL glass, one professional takes water from B1 and places it in the B2. Meanwhile, the other uses the 50 mL glass to take water from B2. This analogy demonstrates that HD doesn’t remove all liquid someone can drink. Hence, water intake control necessity. Nutritionist clarifies patients’ nutritional concerns, while the psychologist addresses emotional issues. We compared percentage of IWG and absences in two months before and after BD.ResultsAfter BD, we observed decreases in absences (7,2% X 5,7%) p < 0,05 and IWG (4,9% X 4.1%) p < 0,05. IWG was within recommended levels (3.5% to 5% of dry weight) before and after BD, but, before BD, IWG was at the upper limit of the recommendation.ConclusionWe believe this experience fostered self-control, resulting in better compliance, and allowed us to benefit from an innovative work interaction between health professionals from different areas.
1794 – Augmentative Repetitive Transcranial Magnetic Stimulation (rtms) In The Acute Treatment Of Drug-resistant Depression
Authors: Camuri G. , Dell’Osso B. , Guerrieri I. , Arici C. , Oldani L. , Altamura A.C. 
Published: July 2013

IntroductionrTMS is a non invasive technique, used for the stimulation of the Dorsolateral Prefrontal Cortex (DLPFC) by means of coil-generated magnetic fields [1,2]. The present study was aimed to assess efficacy and tolerability of augmentative low and high frequency rTMS in TRD patients, with current moderate-severe major depressive episode.Methods24 patients with a diagnosis of drug-resistant Major Depressive Episode (Unipolar or Bipolar Depression) were treated with 4 weeks of rTMS. Subjects were randomly assigned to one of the following treatments: right DLPFC, 1 Hz, 110% of motor threshold (MT), 420 stimuli/day; right DLPFC, 1 Hz, 110% MT, 900 stimuli/day; left DLPFC, 10 Hz, 80% MT, 750 stimuli/day, according to safety guidelines [3]. Analyses were performed using t-test and ANOVA.Results3 subjects dropped out at the 1st or 2nd weeks of stimualtion. 21 patients completed the treatment, showing a statistically significant score reduction at HAM-D, MADRS, HAM-A e CGI-s (tr = 9.05, p < 0.005; tr = 7.93, p < 0.005; tr = 6.81, p < 0.005; tr = 4.37, p < 0.005). Response (reduction of HAM-D score of 50%) was achieved by 2 patients, one of whom considered remitter (HAM-D≤8). Partial response (reduction of HAM-D score between 25-50%) was obtained by 12 patients. No significant difference was observed in terms of efficacy between high vs low frequency. With respect to tolerability, only mild and transient side-effects were reported (discomfort, headache, insomnia). One patient withdrew because of hypomanic switch.ConclusionsBoth augmentative low and high-frequency rTMS appeared to be equally effective and well tolerated in the treatment of TRD.
1798 – Perfectionism, Insomnia And Depressive Symptoms In The Post-partum
Authors: Macedo A. , Bos S.C. , Soares M.J. , Marques M. , Maia B.R. , Azevedo M.H. , Valente J. , Nogueira V. , Madeira N. , Roque C. , Pereira A.T. 
Published: July 2013

IntroductionIt has been shown that perfectionism constitutes a risk factor both for insomnia and postpartum depression.ObjectiveTo analyse the relationship between perfectionism, depressive symptoms and insomnia in the postpartum.Methods201 3-months postpartum women (M=12.27 ± .91 weeks postpartum) completed the Portuguese versions of Postpartum Depression Screening Scale (PDSS) and Multidimensional Perfectionism Scale (MPS). Three MPS dimensions derived by factorial analysis with data from this sample were used: Self-Oriented Perfectionism/SOP, Social Prescribed Perfectionism-Conditional Acceptance/SPP-CA and SPP-Others Highs Standards/OHS. Women also answered 5 questions about sleep, considering the previous month, based on which three insomnia groups were formed: Good Sleepers/GS (women without insomnia symptoms or daytime impairment); Insomnia Symptoms Group (women with at least one insomnia symptom but no daytime impairment); Insomnia Syndrome Group/ISG (women with at least one insomnia symptom and sleep related daytime impairment).ResultsInsomnia and PDSS were correlated (r = .39, pr < .01). SOP was not correlated with insomnia neither with PDSS total score. SPP-CA was significantly correlated with insomnia and with PDSS (rr > .25, pr < .01). SPP-OHS was only significantly correlated with insomnia (r = .14, pr < .05). SPP-CA mean scores were significantly higher in ISG than in GS (23.45 ± 3.032 vs. 18.98 ± 8.81, p = 002). Considering insomnia as a quantitative variable, linear regression showed that SPP-CA (β = .20, p = .005) and PDSS (β = .17, p = .021) were both significant predictors of insomnia, explaining 8.7% of variance (pr < .001). The mediation analysis revealed that SPP-CA partially mediated the relationship between PDSS and insomnia (IC 95% .008-.005).ConclusionSPP-C is a relevant correlate of postpartum insomnia.
1812 – Complex Neuropsychiatric Symptoms After Suicidal Attempt By Double Gunshot To The Head
Authors: Croca M. , Mendes T. , Vian J. , Frade P. , Maltez J. , Levy P. 
Published: July 2013

Cranioencephalic trauma and resulting traumatic brain injury are sometimes associated with hard to manage psychiatric symptoms, requiring interpretation from an integrated neuropsychiatric perspective.We present the case of a 49-year-old man with no known psychiatric history who attempted suicide by gunshot to the head resulting in severe cranioencephalic trauma (GCS=7) and subsequent admission to our hospital's Neurosurgery ward. Brain-CT showed two intracranial projectiles, in left temporal and right occipital topography, as well as multiple haemorragic foci. He was transferred to our Psychiatry ward, as there was no neurosurgical indication and he repeatedly attempted suicide. At admission, he presented with level of consciousness fluctuations, temporospatial disorientation, anosognosia and difficult to assess depressive symptoms. Brief neuropsychological evaluation showed deficits on visual-perceptive abilities, executive functions, logical reasoning, and immediate verbal memory, with a MoCA (Montreal Cognitive Assessment) total score under the normative values. Some language capacities (i.e. naming and repetition) were found to be preserved. Neuroophthalmological evaluation evidenced damage to the anterior left optic tract and a right campimetric defect. The EEG revealed no epileptic activity. At the 34th day of hospitalization, after accidental choking, he began to exhibit delirium with accompanying psychotic symptoms. Presently, two-and-a-half months after admission, we observe remission of delirium, coherent and organized speech, an alexithymic pattern of response, ideative perseverance and no suicidal ideation.The noteworthiness of this case resides on the scarcity of published reports and on the difficulty it presents in terms of therapeutic and post-discharge management, originating from the hard-to-interpret symptoms and uncertain prognosis.
1818 – Early Onset Dementia: Socio-demographic And Clinical Characteristics
Authors: Guermani M. , Robbana L. , Moula O. , Bouasker A. , Ghachem R. 
Published: July 2013

IntroductionEarly onset dementia (EOD) is conventionally defined by age of onset less than 65 years. It is increasingly recognized as a real public health problem because it reaches potentially active people. Although little studied, it is not uncommon and has some clinical and etiological features.ObjectiveThe aim of our study was to evaluate the prevalence of early onset dementia in psychiatric consultation to examinate sociodemographic, clinical and etiological characteristics of this entity.Materials and methodsIt is a cross-sectional study in external consultation of the psychiatric hospital Razi. We collected the records of patients seen between 01/09/2011 and 01/09/2012 and in whom the diagnosis of dementia was retained as the diagnostic criteria of DSM IV.We compared the epidemiological, clinical, and evolutionary dementia, beginning before the age of 65 with late onset dementia (LOD) (after 65 years).Results50 patients were included. The prevalence of EOD was estimated at 20% of all dementias. There was an over representation of men in the early onset group. MMS average score of our patients was 16. This score did not differ between the two groups but differed significantly according to the etiological diagnosis. Alzheimer's disease was the main etiology for both groups. Compared to late-onset dementia, the EOD is characterized by greater heterogeneity in the etiologic diagnosis.ConclusionThe EOD and the LOD seem to have common characteristics, but some features of the EOD especially etiological, emphasize the value of a more comprehensive approach to the research of curable dementia.
1824 – Menstrually Related Cyclothymia: a Case Report
Authors: Skokou M. , Gourzis P. 
Published: July 2013

IntroductionPremenstrual dysphoric disorder is a premenstrual syndrome comprising physical and psychic symptoms. Bipolar disorders, particularly “soft” forms, share symptoms such as depressive mood, irritability or mood reactivity with premenstrual dysphoric disorder, posing challenges on differential diagnosis. In the present work a case of a woman suffering from cyclothymia is reported, with mood episodes confined in the luteal phase of the menstrual cycle.MethodsCase Report.ResultsA 42-year-old married Caucasian woman is presented, suffering from mood disorder episodes lasting for 10-12 days each, during the luteal phase of the menstrual cycle, and remitting after the beginning of her menses. The mood episodes occurred since the age of 20, in almost every menstrual cycle. The patient described hypomanic symptoms during the first 4-5 days of the luteal phase, reporting irritable mood, pressured speech, increased libido as well as vividness of her perceptions and excessive goal-directed activity. The hypomanic symptoms were followed by irritable and depressive mood, fatigue, hypersomnia, tearfulness, decreased self-esteem and pessimism, lasting for another 6-7 days. The patient also reported migraine and binge-eating episodes during each depressive phase. A full range of examinations, including blood and hormonal tests, yielded normal results. Lamotrigine was titrated at 200 mg/day, with subsequent amelioration of symptoms.ConclusionsThe exact relationship between premenstrual dysphoric disorder and other disturbances, which either coexist, or deteriorate premenstrually, or even synchronize with the menstrual cycle, has not been elucidated yet. Studies aiming at a better understanding of this relationship could aid at accurate diagnosis and treatment.
1828 – Improving Patient Safety In Mental Health Through Quality Risk Management
Authors: Cheema F. , Mckechnie L. , Riley P. , Carlyle A. , Ross J. , Renwick C. , Hall D. 
Published: July 2013

Fig. 1[Improvement in daily accessible risk assessments]We show enhanced patient safety through a quality improvement methodology project in an intensive psychiatric care unit of a psychiatric hospital in southwest of Scotland. This is a project as part of the national patient safety programme in mental health. The Scottish Patient Safety Programme for Mental Health aims to systematically reduce harm experienced by people using mental health services in Scotland, by supporting frontline staff to test, gather real-time data and reliably implement interventions, before spreading across their catchment area.Multidisciplinary staff worked together in improving recording of daily electronic and paper based risk assessments from a baseline of 20% to nearly 100% over a sixth month period. We expect better quality risk management by readily accessible risk assessments and safe practise through enhanced safety perception by the patients as well as staff. Patient and staff safety perception tools were designed to measure impact of improvement in risk management. We have seen drop in the number of critical incidents and challenging situations requiring restraint following coordinated approach to risk assessment and easy access to key information. We have been successful as the frontline staff became part of the process of change and this has enabled sustained improvement.