bluuebunny/crossref_metadata_2025_split huggingface dataset:
834 – Fighting Stigma of Psychiatric Disorders in Czech Republic
Authors: Ociskova M. , Prasko J. , Cerna M. , Grambal A. , Jelenova D. , Kamaradova D. , Latalova K. , Sedlackova Z. 
Published: July 2013

The most stigmatized patients are those suffering from schizophrenia and bipolar disorder, and highly affected are also patients with personality disorders, eating disorders, anxiety and OCD. There can also be a stigma in the psychiatric treatments. Psychopharmacs can be labelled as toxins that alter the psyche or body, psychotherapy as a brainwashing. Stigma of mental disorder is connected with a lack of knowledge about psychiatric disorder, fear, prejudice and discrimination of the patients.Czech mass media significantly contribute to the stigmatization of patients with mental disorder.There are already some programs with destigmatization message in the Czech Republic. These programs are in charge of organizations focused on patients with mental disorders, as well as individual professionals or even nonspecialists. the Czech psychiatric association declared the National Psychiatric Program. This program aims to improve the quality of psychiatric care with emphasis on the humane condition of the care and destigmatization. There are also several articles and TV relations describing the psychiatric patients non-stigmatization way published in local newspapers and magazines every year wrote by leading experts in psychiatry. Directly to the patients and their families there were published more than 45 books and about 40 booklets with most often psychiatric problems. Many patients found the information and stories helpful and were more comfortable seeking the treatment.Supported by:IGA MZ CR NT 11047-4/2010
848 – Assessment Of Spirituality Among Opiates Addicts During Detoxification And During Rehabilitation Program With Open Group Therapy
Authors: Rady A. , Salama H. , Molokhia T. , El-Nahas M. 
Published: July 2013

BackgroundThere's an increasing professional and popular interest in relation of spirituality and general health. Although mental health professionals have traditionally avoided concerns, evidence has been accumulating that people with mental illness attach significance to spiritual beliefs. In contrast, around 60% of psychiatrists report minimal interest in spiritual matters. Some authors found spiritual well being as an active relation with a higher power to be positively correlated to good mental health.MethodCross sectional comparative study design, 60 patients during detoxification and 20 patients in rehabilitation program with open group psychotherapy after detoxification, demographic data were collected and participants were subjected to spirituality subscale from substance misuse program philosophy questionnaire Arabic version.ResultsResponse to the 6 questions of the spirituality subscale used to assess level of spirituality didn’t show difference among the three groups, those during detoxification, those less than 3 months abstinence and those more than 3 months abstinence in rehabilitation program with open group psychotherapy.ConclusionSpirituality is persistently high through out detoxification and residential rehabilitation program. Spiritually inspired psychological intervention may be of help during the whole course of management of opiates addicts.
850 – Panic Disorder With And Without Personality Disorders-therapeutic Outcome Of Pharmacoresistant In-patients
Authors: Kamaradova D. , Prasko J. , Grambal A. , Diveky T. , Jelenova D. , Latalova K. , Cerna M. , Ociskova M. , Sigmundova Z. 
Published: July 2013

Most clinicians tend to believe that the occurrence of the anxiety disorder in tandem with a personality disorder often leads to longer treatment, worsens the prognosis, and thus increasing treatment costs. The study is designed to compare the shortterm effectiveness of combination of cognitive behavioral therapy and pharmacotherapy in patient suffering with panic disorder with and without personality disorder.MethodWe compared the efficacy of 6 week therapeutic program in pharmacoresistant patients suffering with panic disorder and comorbid personality disorder (19 patients) and panic disorder and/or agoraphobia without comorbid personality disorder (43 patients). Patients were treated with CBT and psychopharmacs. They were regularly assessed every week on the CGI, BAI, BDI. Before and after treatment were used also Sheehan anxiety scale, Dissociative experience scale, Quality of Life.ResultsA combination of CBT and pharmacotherapy proved to be the effective treatment of patients suffering with panic disorder and/or agoraphobia with or without comorbid personality disorder. The treatment effect between groups did not differ in rating scales, but there are more remitted patients in group without personality disorder.Supported by: Project IGA MZ ČR NS 10301-3/2009
857 – Findings From An Online Drug Monitoring And Safety Registry For Children Prescribed Antipsychotics
Authors: Wegner S.E. , Trygstad T. , Wegner L.M. , Christian R. , Farley J.F. , McKee J. , Pfeiffenberger T. , Stiles A.D. , Moran K. , Sheitman B. 
Published: July 2013

IntroductionThere is widespread concern over the perceived indiscriminant prescribing of antipsychotic medications in children, particularly for those residing in low-income households or foster care. Ongoing safety and efficacy monitoring is suggested by many professional associations.ObjectivesDescribe reported diagnosis and symptomology for over 15,000 children prescribed antipsychotics in the 17- month period from April 2011 through August 2012.AimsIncrease appropriate monitoring of children who are prescribed antipsychotics.MethodsA policy was developed by the North Carolina Division of Medical Assistance, in collaboration with Community Care of North Carolina, that requires prescribers to register patients via a web portal before reimbursement is allowed to the pharmacy. Required registration elements include a patient's primary diagnosis, target symptom for medication use, initiating prescriber, caregiver support of medication use, adverse drug event reporting, and metabolic monitoring deemed best practice by the literature review.ResultsFrom April of 2011 through August 2012, a total of 1,241 prescribers have written 29,691 prescriptions for 15,194 patients in the A+KIDS program. Unspecified Mood Disorder was the first most common representing 22%.of patients. Bipolar Disorder, Autism Spectrum Disorder, and ADHD, followed at 14%, 12%, and 12% respectively. “Aggression towards others,” “Irritability” and “Tantrums/temper” were the most common target symptoms (representing 63.6% of patients).
862 – Psychotherapy For Girls With Anxiety Disorders: a Culturally Sensitive Approach
Authors: Trangkasombat U. 
Published: July 2013

Background:Anxiety disorders are common in children. Much of anxiety in children is embedded in the parent- child relationship. In Asian countries many cultural practices can lead to insecure attachment and severe stress in children, especially in girls. Appropriate psychotherapeutic intervention must be sensitive to cultural influences.Objective:To report clinical symptoms, individual and family dynamics, important points in psychotherapy for a girl with an anxiety disorder.Method:A Thai-Chinese 9 year- old girl presented with obsessions about her mother dying and herself killing her mother. She also had hallucinations which she described as “voices telling me to kill my mother”. She was diagnosed as having OCD with psychotic features. The patient was the first twin and was described as a ‘moody’ and ‘not so smart’, while her twin brother, the only male grandchild of the family, was described as ‘pleasant’ and ‘clever’.Result:Family assessment revealed cultural practices that led to severe frustration and anxiety in this girl. The main factor was the practice of son preference. This, together with severe punishment, led to insecure attachment, feelings of rejection, anger, guilt and shame. Family therapy and behavior management were the main psychotherapeutic interventions in the early phase. CBT was initiated in the later phase. Interesting points in treatment and the VDO tape of psychotherapy sessions will be presented.Conclusion:The case vignette illustrated the role culture plays in initiating severe anxiety in girls. Understanding such a role will enable therapists to treat anxiety in girls more effectively.
863 – Vortioxetine, An Investigational Antidepressant: Implications Of Its Multimodal Mechanism Of Action In Preclinical Models Of Depression And Cognitive Function
Authors: Sanchez C. 
Published: July 2013

BackgroundVortioxetine is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter (SERT).ObjectivesTo study the in vitro properties of vortioxetine at rat and human targets and relate them to rat brain target occupancies and effects in rat models assessing antidepressant activity and cognitive function.MethodsThe in vitro properties were assessed using radioligand binding and cell-based functional assays, brain target occupancies were studied using ex vivo autoradiography, antidepressant activity was studied in conventional behavioural models and in a progesterone withdrawal model, and effects on cognitive function were assessed by quantitative EEG [qEEG] and after 5-HT depletion in recognition and spatial memory tasks.ResultsVortioxetine was more potent at human than rat 5-HT1A and 5-HT7 receptors and the SERT, whereas the opposite was found for 5-HT1D and 5-HT3 receptors. The rat in vitro and ex vivo potency rank orders were aligned. Vortioxetine showed antidepressant activity in conventional models and the fluoxetine-insensitive progesterone withdrawal model. qEEG analyses demonstrated increases across power bands with vortioxetine, but not duloxetine or escitalopram. Vortioxetine restored memory deficits induced by low 5-HT, whereas duloxetine and escitalopram had no effect.Conclusions1.Species comparisons of target activities and inclusion of target occupancy measures in animal studies supports thetranslation from preclinical to clinical settings.2.Vortioxetine exerts antidepressant and memory-enhancing effects in rats via mechanisms beyond that of SERT inhibition.
870 – The Prevalence Of Personality Disorders In Psychiatric Outpatients With An Intellectual Disability
Authors: Wieland J. , Wardenaar K. , Van den Brink A. , Zitman F.G. 
Published: July 2013

IntroductionThe diagnosis of personality disorder (PD) in individuals with an intellectual disability (ID) is clinically relevant, but there is little research on the subject. Because the impact of PD on both patients and carers is substantial, it is important to increase the understanding of how ID and PD co-occur.ObjectivesThe aim of the present study was to examine the prevalence of all axis II DSM-IV-TR PD diagnoses in a well- defined sample of ID out-patients in two specialized secondary care ou-patient treatment centers, in the Netherlands. Special attention was paid to borderline ID (70≤Total IQ < 85), prevalence of co-morbid axis I disorders and associations of PD with several demographic variables.MethodsThe present study was a cross-sectional medical chart review. On January first, 2011, 599 patients were registered at the two centers. Diagnostic information was available for 576 patients. Diagnoses were based on Došen's integrative approach and formulated according to the DM-ID.Results194 patients (33.7%) were diagnosed with a PD. PD NOS (19.1%) was most common, followed by borderline PD (8.7%). Patients with borderline ID were most likely to be diagnosed with a PD (43.7%). 85.1% of patients diagnosed with a PD had at least 1 co-morbid axis I diagnosis. PTSD was the most common co-morbid disorder (23.7%).ConclusionDiagnosed according to strict criteria, PDs often occur in ID out-patients, mostly together with axis I disorders. Importantly, PDs and PTSD often co-occur in this group, indicating special care needs and signifying an interesting direction for further research.
880 – Mutual Interaction Of Personality And Sexuality: a New Model For The Treatment Of Sexual Dysfunctions
Authors: Pirkalani K.K. , Talaee Rad Z. 
Published: July 2013

IntroductionPersonality, also designed as one's identity gives color to the notions, beliefs, social activities, self image … We wondered how personality could affect sexual life and functioning in a systematic way.ObjectivesMany sexual dysfunctions, either primary or acquired are rooted in deep personality related beliefs and cannot be treated easily.AimsTo find newer ways of treating more profound psychopathology in patients with sexual dysfunction by adding personality guided therapy into the sex therapy sessions.MethodsFifty four patients with sexual dysfunction were evaluated by Millon's clinical Multiaxial inventory III in addition to Questionnaire on Sexual attitude and function 2009. Half the patients received only sex therapy and if needed drug therapy while the other half received additionally intensive (twice weekly) personality guided therapy which included supportive psychotherapy, cognitive therapy and behavior therapy based on the personality category diagnosed at the beginning. After 12 weeks, both groups were evaluated with the same tools in addition to a clinical interview.ResultsThe latter group fared significantly (p< 0.03) better in regard to both personality and sexuality scales. A reduction of anxiety, depression, alcoholism and drug abuse scales was also encountered. Patients in the latter group explained themselves less disturbed, less ashamed and more ambitious to solve their problems as exemplified by the clinical interview.ConclusionsPersonality is a more and possibly the sole prominent risk factor of sexual dysfunction in the majority of patients and inclusion of treatment in this regard is extremely effective and with faster response.
904 – Prevalence And Co Morbidity Of Adult Adhd In Psychiatric Outpatient Admissions
Authors: Duran Ş. , Fistikci N. , Keyvan A. , Bilici M. 
Published: July 2013

AimIn the present study, the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) in adult psychiatric outpatients was investigated. Moreover, co morbid psychiatric diagnoses in adults with ADHD were determined. Patients with and without co morbid ADHD were compared regarding axis I-II co morbidity and socio-demographic characteristics.MethodThe current study included 246 patients admitted for the first time to Numune Hospital psychiatric outpatient clinic in a four months period where they were evaluated for adult ADHD. Diagnosis of ADHD was made by evaluating symptoms of childhood via WURS scale, Turgay's adult ADD / ADHD evaluation scale. For the exact diagnosis DSM-IV criteria were applied to the patients who exceeded the cut of points of both above-mentioned scales. To assess the presence of psychiatric co morbidity a structured clinical interview (SCID-I and II) were applied. Socio demographic characteristics of patients were determined with a semi-structured form. In addition, to grade general psychopathology, Symptom Check List (SCL-90-R), Beck Depression Inventory (BDI) were given.ResultsPrevalence of ADHD in adult psychiatric clinic was 15.9%. Adults with ADHD usually referred due to co morbid psychiatric problems. It was determined that they had deficits in education and social functions. Substance abuse and suicide were among the most prevalent psychiatric problems.ConclusionADHD was common in adult psychiatric outpatients and axis I-II co morbidity was highly prevalent among these patients.
910 – Schizophrenia And Violence At Home
Authors: Nascimento Osorio M.T. , Sabate Gomez A. , Corcoles Martinez D. , Gines Miranda J.M. , Gomez Perez L. , Bellsola Gonzalez M. , Gonzalez Fresnedo A.M. , Martin Lopez L.M. , Bulbena Vilarassa A. , Gasque Llopis S. , Castillo Magaña S. 
Published: July 2013

IntroductionThere is good evidence from epidemiological studies that the diagnosis of schizophrenia is associated with an increased risk of violence.Some studies have linked the presence of positive symptoms, first psychotic episode, duration of untreated psychosis and lack of insight with violent behavior.ObjectiveThe primary objective was to identify factors related to violent behavior in patients diagnosed with psychotic disorder attended by our group, a multidisciplinary mobile outreach team (EMSE).MethodologyWe evaluated a total of 249 patients diagnosed with psychotic disorder between 2007 and 2012. We administered the following scales: PANSS, GAF (Global Assessment of Functioning), CGI (Clinical Global Impression), GEP (Severity of psychiatric illness scale, AVAT (Instrument to assess violent behavior in mental illness) and SUMD (Scale unawareness of mental disorders). To study the correlation between the scales and the score of the AVAT instrument we used the Pearson correlation. Clinical variables were also compared between aggressive and non-aggressive patients using Chisquare and Student's.ResultsThere is a positive correlation between AVAT and PANSS-P (r = 0.544), ICG (r = 0.472), GEP (r = 0.515) and a negative correlation between AVAT and GAF (r = -0357). The correlation between AVAT and SUMD is positive (r = 0.119) but not statistically significant.ConclusionThe presence of positive symptoms and clinical severity has been linked to increased aggressiveness and to predict the occurrence of violent behavior in the course of psychotic disorder. Unlike other studies, no correlation was observed with the lack of insight.
923 – Safe Administration Of Clozapine In Hospitalized Psychiatric Patients
Authors: Begic D. , Bise S. , Kurtovic B. , Cemalovic O. , Ahmic M. 
Published: July 2013

Clozapine is indicated for the management of severely ill schizophrenic patientswho fail to respond adequately to standard drug treatment for schizophrenia. Agranulocytosis is a life-threatening adverse effect which can occur during administration of clozapine, and frequency estimation is between 0,5 and 2 % of patients. This research was conducted in 136 patients treated with Clozapine, from a total number of 528 patients hospitalized in the Psychiatric Hospital of Sarajevo in one year period. Fifty patients (36,26%) from total were females, and 86 patients (63,74%) were male. Average age was 43,43 years, hospitalized approximately 4,55 times in this hospital, they were treated with Clozapine in mono- or combined therapy with middle dosage of 162,32 mg per day. In most of the cases (68,75%) concomitant therapy was associated to Haloperidole.According to recommendations of manufacturers and algorithms, laboratory blood monitoring and differential blood monitoring were performed.In this trial there were no cases what so ever that would include differation of total White Blood Cells number or granulocytes of patients hospitalized and treated with Clozapine in one year period.
924 – Synergetic Integrative Model Of Group Psychotherapy For Schizophrenic Patient Relatives
Authors: Prazdnova V. , Zelenkova T. 
Published: July 2013

IntroductionThe authors propose an integrative approach in group work psychotherapy for schizophrenic patient’s relatives. This approach integrates three components into session: psycho education (knowledge for systemic family psychotherapy), cognitive behavior (family solving problem skills) and psychotherapy (reflection and coping strategies). These components are integrative for communication process, which provides their synergetic interaction within the theme educate limits.ObjectivesStudy the effectiveness of a synergetic approach in enhancing the impact of rehabilitation.AimsIdentifying markers of efficacy of the approach through a comparative analysis of the two groups of mothers of patients, one of whom used a synergistic approach, in the other using traditional programs.MethodsSCL-90-R (Derogatis); URICA (McConnaughy); MSPSS(Zimet). Objective conclusion is provided by using Mann-Whitney U-test.ResultsSynergetic integrative approach to group therapy significantly affects the reduction of somatization (p = 0,05), depression (p = 0,01), hostility (p = 0,05) and Global Severity Index (p = 0,05). In participants of the experimental group was significantly higher overall perception of social support (p = 0,01), measures of social support from family (p = 0,05), friends (p = 0,01) and significant others (p = 0,05). Diagnostic stage of psychotherapeutic process showed that participants of the control group mostly are on initial stages of therapy, while the experimental group members are at a mature stage.ConclusionsSynergetic integrative approach showed high efficiency to work with the families of schizophrenic patients by reducing the level of psychiatric symptoms, enhance feelings of social support and accelerate the psychotherapeutic process.
926 – Emotional Processing In Patients With Affective, Borderline And Dissociative Disorders
Authors: Grambal A. , Prasko J. , Cerna M. , Havlikova P. , Kamaradova D. , Ociskova M. , Sedlackova Z. , Sandoval A. , Sigmundova Z. , Latalova K. 
Published: July 2013

Many of patients suffering with affective, dissociative and dissociative disorders experienced significant stressful or traumatic events from childhood or later in their life. Many of them suffer as children with unsatisfactory fulfilled basic child's needs, such as security, acceptance or approbation. Without the systematic processing these traumatic experiences the treatment is unsuccessful and their problems persist. Although CBT stresses the importance of cognitions or thoughts in activating or maintaining negative affects, there has been increasing emphasis on considering the role of emotional processing. Many of our patients believe that one should be rational and logical all the time, never have conflicting feelings, and should ruminate in order to figure things out. Meaningful cognitive and simultaneously experiential technique for working with deep emotional schemas, formatted in childhood, is imaginal rescripting of the traumatic events, role playing and writing the therapeutic letters. Inclusions of emotion regulation skills in the treatment especially for patients with dissociative disorders enhance the efficacy of CBT. Several examples of emotional processing and trauma rescripting will be presented.Supported by the project IGA MZ CR NT 11047-4/2010
955 – Long-term Effectiveness Of Long- And Short-term Psychotherapy In The Treatment Of Depressive And Anxiety Disorders
Authors: Knekt P. , Jääskeläinen T. , Virtala E. , Härkänen T. , Laaksonen M. , Lindfors O. 
Published: July 2013

IntroductionLittle is known about long-term effects of psychotherapy on depressive or anxiety disorders.AimsTo compare the effectiveness of three psychotherapies of different length in a clinical trial with a 5-year follow-up.MethodsIn the Helsinki Psychotherapy Study, 326 outpatients with mood or anxiety disorder were randomly assigned to longterm psychodynamic psychotherapy (LPP), short-term psychodynamic psychotherapy (SPP), and solution-focused therapy (SFT), and were followed up for 5 years from start of treatment. Depressive, anxiety and general psychiatric symptoms (BDI, SCL-90-Anx, and SCL-90-GSI), working ability (WAI), and recovery (based on changes in psychiatric symptoms and use of auxiliary treatment) were used as outcome measures.ResultsFor patients with depressive disorder LPP was more effective than SPP or SFT in reducing symptoms, improving work ability and leading to recovery during the 3 last years of follow-up. For patients with anxiety disorder effectiveness of LPP was less pronounced with no differences between short-term and long-term therapy in recovery from anxiety symptoms. No differences were found between the effectiveness of the short-term therapies.ConclusionsLong-term psychotherapy is more effective than short-term therapy during a long follow-up especially in the treatment of depressive disorder. More research especially considering different anxiety disorders is still needed.