bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomics Reveals Broad-Scale Metabolic Perturbations in Hyperglycemic Mothers During Pregnancy
Authors: Scholtens Denise M. , Muehlbauer Michael J. , Daya Natalie R. , Stevens Robert D. , Dyer Alan R. , Lowe Lynn P. , Metzger Boyd E. , Newgard Christopher B. , Bain James R. , Lowe William L. ,   for the HAPO Study Cooperative Research Group
Published: August 2013

OBJECTIVETo characterize metabolites across the range of maternal glucose by comparing metabolomic profiles of mothers with high and low fasting plasma glucose (FPG).RESEARCH DESIGN AND METHODSWe compared fasting serum from an oral glucose tolerance test at ∼28 weeks’ gestation from 67 Northern European ancestry mothers from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study with high (&gt;90th percentile) FPG with 50 mothers with low (&lt;10th percentile) FPG but comparable BMI. Metabolic data from biochemical analyses of conventional clinical metabolites, targeted mass spectrometry (MS)-based measurement of amino acids, and nontargeted gas chromatography/MS were subjected to per-metabolite analyses and collective pathway analyses using Unipathway annotation.RESULTSHigh-FPG mothers had a metabolic profile consistent with insulin resistance including higher triglycerides, 3-hydroxybutyrate, and amino acids including alanine, proline, and branched-chain amino acids (false discovery rate [FDR]-adjusted P &lt; 0.05). Lower 1,5-anhydroglucitol in high-FPG mothers suggested recent hyperglycemic excursions (FDR-adjusted P &lt; 0.05). Pathway analyses indicated differences in amino acid degradation pathways for the two groups (FDR-adjusted P &lt; 0.05), consistent with population-based findings in nonpregnant populations. Exploratory analyses with newborn outcomes indicated positive associations for maternal triglycerides with neonatal sum of skinfolds and cord C-peptide and a negative association between maternal glycine and cord C-peptide (P &lt; 0.05).CONCLUSIONSMetabolomics reveals perturbations in metabolism of major macronutrients and amino acid degradation pathways in high- versus low-FPG mothers.
GLP-1 Responses Are Heritable and Blunted in Acquired Obesity With High Liver Fat and Insulin Resistance
Authors: Matikainen Niina , Bogl Leonie H. , Hakkarainen Antti , Lundbom Jesper , Lundbom Nina , Kaprio Jaakko , Rissanen Aila , Holst Jens J. , Pietiläinen Kirsi H. 
Published: August 2013

OBJECTIVE
Impaired incretin response represents an early and uniform defect in type 2 diabetes, but the contributions of genes and the environment are poorly characterized.

RESEARCH DESIGN AND METHODS
We studied 35 monozygotic (MZ) and 75 dizygotic (DZ) twin pairs (discordant and concordant for obesity) to determine the heritability of glucagon-like peptide 1 (GLP-1) responses to an oral glucose tolerance test (OGTT) and the influence of acquired obesity to GLP-1, glucose-dependent insulinotropic peptide (GIP), and peptide YY (PYY) during OGTT or meal test.

RESULTS
The heritability of GLP-1 area under the curve was 67% (95% CI 45–80). Cotwins from weight-concordant MZ and DZ pairs and weight-discordant MZ pairs but concordant for liver fat content demonstrated similar glucose, insulin, and incretin profiles after the OGTT and meal tests. In contrast, higher insulin responses and blunted 60-min GLP-1 responses during the OGTT were observed in the heavier as compared with leaner MZ cotwins discordant for BMI, liver fat, and insulin sensitivity. Blunted GLP-1 response to OGTT was observed in heavier as compared with leaner DZ cotwins discordant for obesity and insulin sensitivity.

CONCLUSIONS
Whereas the GLP-1 response to the OGTT is heritable, an acquired unhealthy pattern of obesity characterized by liver fat accumulation and insulin resistance is closely related to impaired GLP-1 response in young adults.
Gnathostoma binucleatum antigens induce peripheral blood lymphocytic cells proliferation
Authors: Zambrano-Zaragoza J. , J. Durán-Avelar M. , Messina-Robles M. , Vibanco-Pérez N. 
Published: August 2013

Abstract
Gnathostomiasis is an emerging infectious disease, in which the agent Gnathostoma binucleatum is the only species known to infect humans in Mexico. Although the humoral immune response to G. binucleatum has been analyzed previously, here we evaluated the lymphoproliferative response of peripheral blood lymphocytic cells from patients clinically diagnosed with gnathostomiasis against a crude extract of G. binucleatum using the MTT method, and compared the response to that of healthy subjects. No differences in the response to concanavalin A were found between the groups; however, the response to the crude extract was statistically higher in patients compared to healthy controls (1.188 ± 0.135, and 1.000 ± 0.045, p = 0.0004). Patients at > 6 months after diagnosis showed a higher lymphoproliferative response than the group of healthy subjects, and those at < 6 months after diagnosis (p = 0.0001, and 0.0164 respectively). These data suggest that the parasite induces non-protective immunological memory.
Cartographie successive des entreprises métallurgiques dans les Pyrénées nord-catalanes ; support préliminaire à l'étude éco-historique des forêts charbonnées
Authors: Izard Véronique 
Published: August 2013

The historic approach of the mountain environment, and this of the dynamic evolution of theforest settlements, which are characterized by the charcoal metallurgy, is included in a combined research project. The successive cartography of the geographic implantation of the iron and steel industry, constitutes a preliminary source document necessary for the study of paleosettlements in the Catalan Pyrénées. The forest, long considered as an inexhaustible energy source, has been in the heart of the protoindustrial economy. Victim of the "charcoal-burners axe", it still shows the scars of a centuries old exploitation, the marks of which are to befound everywhere in the landscape.
Through this study, the spreading of the iron and steel industry, arises quite clearly, both in space and in time, and its repercussions of the environement also appear. It shows a coherent image of the " iron-landscapes ", integral part of the Catalan patrimony.
How to Promote Learning in African Countries? Open d-learning System Based on an Open Content
Authors: Daoudi Najima , Amrous Naila , Ettaki Badia 
Published: August 2013

The learning process has always been a privileged appeal for individuals to improve their knowledge and skills to enable them to become more productive and contribute to the sustainable development of society. However, poverty in most African countries generally, hampers the implementation of the learning process-face. These prove to be expensive when considering the cost of construction of facilities, teaching materials and also paying the teachers for tracking learners and contents production. To overcome the various constraints (personal, social and pedagogic) that impede the classical process of learning, we propose to use an open d-learning system.
It is a learning system that relies largely on contents 2.0 produced by researchers and experts and open content (open archives and open journal). Digital libraries can provide our system with a favorable environment in order to engage learners, motivate them and orientate them along their researches. Pedagogy and technology go together in this system to provide a quality learning environment. Indeed, management systems for the content of the company ECM provide an environment capable of managing the content despite their diversity and dispersal in several servers. The recommended pedagogy is the one which is active and constructive centered on the learner. An open d-learning plays an important role for the promotion of human development and thereby ensures the progress and changes in developing countries. The proposed system deals with an open generic and modular design to meet scalability of content and learning services always evolving. It allows access through several data -processing objects in the first level. The second one provides different learning services such as exercises, assessments, conducting practical work or projects. An intermediate level has been proposed to capitalize and gather the free content on the web identified as being useful for learning to enable their re-use and their sustainability. Finally, the fourth level which is in the form of an educational heritage consists of a free content but rich and varied. Such a system would be able to offer new opportunities for the countries in the process of development to guarantee human development and to become thus more competing at the era of globalization and the emergent technological development.
Multiple bone metastases detected 10 years after mastectomy with silicone reconstruction for DCIS and contralateral augmentation
Authors: Mori Ryutaro , Nagao Yasuko 
Published: August 2013

Key Clinical MessageThe patient developed multiple bone metastases following mastectomy with silicone reconstruction and contralateral augmentation for ductal carcinoma in situ (DCIS) of the breast. She was diagnosed with contralateral invasive cancer. Distant metastasis of DCIS is rare, and other metastatic origins must be screened. However, screening of augmented breasts is difficult.
ChemInform Abstract: Thorium Fluorides ThF, ThF2, ThF3, ThF4, ThF3(F2), and ThF5‐ Characterized by Infrared Spectra in Solid Argon and Electronic Structure and Vibrational Frequency Calculations.
Authors: Andrews Lester , Thanthiriwatte K. Sahan , Wang Xuefeng , Dixon David A. 
Published: August 2013

AbstractLaser‐ablated Th atoms are reacted with different F2 concentrations to produce ThFx (x = 1, 2, 3, 4), ThF3(F2) and ThF5‐.
ChemInform Abstract: Structural Transition and Unusually Strong Antiferromagnetic Superexchange Coupling in Perovskite KAgF3.
Authors: Kurzydlowski Dominik , Mazej Zoran , Jaglicic Zvonko , Filinchuk Yaroslav , Grochala Wojciech 
Published: August 2013

AbstractHigh‐purity samples of KAgF3 are prepared by thermal decomposition of KAgF4 at 440 °C for 6 d.
ChemInform Abstract: Photoconductivity in Tl6SI4: A Novel Semiconductor for Hard Radiation Detection.
Authors: Kanatzidis Mercouri G. , et al. et al. 
Published: August 2013

AbstractThe title compound is synthesized from a stoichiometric mixture of Tl2S and TlI (550 °C, 24 h) and characterized by single crystal XRD, optical diffuse reflectance spectroscopy, conductivity measurements, and FLAPW band structure calculations.
ChemInform Abstract: First Incorporation of the Tetrahedral [Sn4]4‐ Cluster into a Discrete Solvate Na4[Sn4]·(NH3)13 from Solutions of Na4Sn4 in Liquid Ammonia.
Authors: Waibel Markus , Faessler Thomas F. 
Published: August 2013

AbstractNa4[Sn4]·13NH3 is obtained from deep red suspensions of Na4Sn4, Cu‐Mst, and 18‐crown‐6 in liquid NH3 (‐70 °C, 19 weeks, 25% yield).
ChemInform Abstract: Na2.9KMo12S14: A Novel Quaternary Reduced Molybdenum Sulfide Containing Mo12 Clusters with a Channel Structure.
Authors: Gougeon Patrick , Gall Philippe , Salloum Diala 
Published: August 2013

AbstractThe title compound is prepared by reduction of KMo12S14 (I) in Na2S2O3/NaOH (333 K, 3 d).
ChemInform Abstract: Iodine(I) Reagents in Hydrochloric Acid‐Catalyzed Oxidative Iodination of Aromatic Compounds by Hydrogen Peroxide and Iodine.
Authors: Bedrac Leon , Iskra Jernej 
Published: August 2013

AbstractHydrochloric acid activates the oxidative iodination of aromatic compounds (I) and (III) with the iodine‐hydrogen peroxide system through the formation of dichloroiodic(I) acid as iodinating reagent.
ChemInform Abstract: [Omim][BF4] Ionic Liquid, a Green and Recyclable Medium for One‐Pot Aminomethylation of Electron‐Rich Aromatic Compounds.
Authors: Arzephoni Amene Yaghoubi , Naimi‐Jamal M. Reza , Sharifi Ali , Abaee M. Saeed , Mirzaei Mojtaba 
Published: August 2013

AbstractThe employed ionic liquid can be used for at least four consecutive runs without considerable loss of its activity.
ChemInform Abstract: CAL‐B Catalyzed Desymmetrization of 3‐Alkylglutarate: “Olefin Effect” and Asymmetric Synthesis of Pregabalin.
Authors: Jung Jae‐Hoon , Yoon Doo‐Ha , Kang Philjun , Lee Won Koo , Eum Heesung , Ha Hyun‐Joon 
Published: August 2013

AbstractThe title reaction is performed to prepare optically active 3‐alkylglutaric acid monoesters (II) bearing various alkyl substituents.
ChemInform Abstract: Regiospecific Synthesis of Dithiocarbamates via Markovnikov Addition Reaction.
Authors: Halimehjani Azim Ziyaei , Zanussi Hamed Pasha , Ranjbari Mohammad Amin 
Published: August 2013

AbstractN‐Vinylpyrrolidine reacts with dithiocarbamic acids, generated in situ, to give the target compounds as Markovnikov products.
ChemInform Abstract: Ring Expansion of Alkynyl Cyclopropanes to Highly Substituted Cyclobutenes via a N‐Sulfonyl‐1,2,3‐triazole Intermediate.
Authors: Liu Renhe , Zhang Min , Winston‐McPherson Gabrielle , Tang Weiping 
Published: August 2013

AbstractRegioselective ring expansion of alkynyl cyclopropanes to substituted cyclobutenes is described.
ChemInform Abstract: Synthesis of Small Ring‐Containing Conjugated Dienes via the Coupling Reaction of Cyclopropyl‐ and Cyclobutylmagnesium Carbenoids with α‐Sulfonylallyllithiums.
Authors: Kimura Tsutomu , Inumaru Mio , Migimatsu Takuma , Ishigaki Masashi , Satoh Tsuyoshi 
Published: August 2013

AbstractThe deprotonation‐isomerization of sulfones (I) and a subsequent reaction of sulfonylallyllithium intermediates with in situ generated magnesium carbenoids lead to desired adducts (III), (VII), and (IX).
ChemInform Abstract: Organocatalytic Formal [2 + 2] Cycloaddition Initiated by Vinylogous Friedel—Crafts Alkylation: Enantioselective Synthesis of Substituted Cyclobutane Derivatives.
Authors: Duan Guo‐Jian , Ling Jun‐Bing , Wang Wei‐Ping , Luo Yong‐Chun , Xu Peng‐Fei 
Published: August 2013

AbstractBy tandem iminium‐enamine activation of enals transformable pyrrole‐functionalized cyclobutanes are obtained with high regio‐, diastereo‐ and enantioselectivity.
ChemInform Abstract: Palladium‐Catalyzed Intermolecular Dehydrogenative Aminohalogenation of Alkenes under Molecular Oxygen: An Approach to Brominated Enamines.
Authors: Ji Xiaochen , Huang Huawen , Wu Wanqing , Jiang Huanfeng 
Published: August 2013

AbstractThe reaction proceeds with mostly excellent (Z)‐selectivity.
ChemInform Abstract: Regioselective Threefold Aromatic Substitution of Benzoic Acid Derivatives by Dearomatization, Regioselective Functionalization, and Rearomatization.
Authors: Koch Eva , Studer Armido 
Published: August 2013

AbstractThe alkylation of carboxylic acids (I) proceeds with high regio‐ and diastereoselectivity to give products (III).
ChemInform Abstract: New Efficient Ligand‐Free, Copper Nanoparticle Catalyzed Coupling Reactions of Aryl Halides with Diethyl Malonate to Produce α‐Arylation of Malonates.
Authors: Pai Gita , Chattopadhyay Asoke P. 
Published: August 2013

AbstractBoth aryl iodides and bromides can be used with success.
ChemInform Abstract: Ru(II)‐Catalyzed Intermolecular ortho‐C—H Amidation of Aromatic Ketones with Sulfonyl Azides.
Authors: Bhanuchandra M. , Yadav M. Ramu , Rit Raja K. , Kuram Malleswara Rao , Sahoo Akhila K. 
Published: August 2013

AbstractThe Rh(II)‐catalyzed amidation of ketones (I) with tosyl azide leads to ortho‐amidated derivatives (III) as single products.
ChemInform Abstract: Copper(I)‐Catalyzed Stereoselective Synthesis of (1E,3E)‐2‐Sulfonyl‐1,3‐dienes from N‐Propargylic Sulfonohydrazones.
Authors: Zhu Yu , Tang Hai‐Tao , Zhan Zhuang‐Ping 
Published: August 2013

AbstractA new method for the synthesis of highly substituted (1E,3E)‐2‐sulfonyl‐1,3‐dienes (II) from hydrazones (I) is developed via Cu(I)‐catalyzed [3,3]‐rearrangement and highly regioselective migration of the sulfonyl group.
ChemInform Abstract: Desymmetrization and Switching of Stereoselectivity in Direct Organocatalytic Michael Addition of Ketones to 1,1‐Bis(phenylsulfonyl)ethylene.
Authors: Chen Yan ming , Lee Pei‐Hsun , Lin Jun , Chen Lwunmin 
Published: August 2013

AbstractCamphor‐derived pyrrolidine catalyst bearing a thiourea‐group and cinchonidine‐derived catalyst are used to prepare the enantiomeric ketosulfones with comparable yields and stereoselectivities.
ChemInform Abstract: Scope and Limitations of the Heck—Matsuda‐Coupling of Phenol Diazonium Salts and Styrenes: A Protecting‐Group Economic Synthesis of Phenolic Stilbenes.
Authors: Schmidt Bernd , Elizarov Nelli , Berger Rene , Hoelter Frank 
Published: August 2013

Abstract4‐Phenol diazonium salts (II) undergo Pd‐catalyzed Heck reactions with various styrenes (I) to 4′‐hydroxy stilbenes (III).
ChemInform Abstract: Synthesis of Axially Chiral 1,1′‐Binaphthalenes by Palladium‐Catalyzed Cross‐Coupling Reactions of Triorganoindium Reagents.
Authors: Mosquera Angeles , Pena Miguel A. , Perez Sestelo Jose , Sarandeses Luis A. 
Published: August 2013

AbstractIn some cases increasing the amount of triorganyl indium reagent can increase the yields of the products [cf.
ChemInform Abstract: Palladium‐Catalyzed Formation of C=C Bonds: A Regioselective Strategy for the Synthesis of 2‐Vinylfurans by 1,2‐H Shift of Palladium—Carbene Complexes.
Authors: Zhan Haiying , Lin Xiulian , Qiu Yanying , Du Zuodong , Li Peixian , Li Yongjian , Cao Hua 
Published: August 2013

AbstractThe authors present a new one‐pot cyclization reaction to the corresponding furan derivatives which proceeds under mild conditions.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Cyclic Ethers Containing an α‐Tetrasubstituted Stereocenter.
Authors: Cox Nick , Uehling Mycah R. , Haelsig Karl T. , Lalic Gojko 
Published: August 2013

AbstractAn exo‐selective cyclization of enantioenriched trisubstituted allenes is developed in the presence of combined Au/Ag catalyst which allows the asymmetric preparation of cyclic ethers containing a tetrasubstituted stereocenter.
ChemInform Abstract: Direct Access to Benzo[b]furans Through Palladium‐Catalyzed Oxidative Annulation of Phenols and Unactivated Internal Alkynes.
Authors: Kuram Malleswara Rao , Bhanuchandra M. , Sahoo Akhila K. 
Published: August 2013

AbstractVarious different substituted benzofurans are synthesized by this novel one‐pot procedure starting from readily accessible unactivated alkynes.
ChemInform Abstract: Efficient Pseudo‐Five‐Component Coupling‐Fiesselmann Synthesis of Luminescent Oligothiophenes and Their Modification.
Authors: Teiber Marco , Giebeler Soenke , Lessing Timo , Mueller Thomas J. J. 
Published: August 2013

AbstractSymmetrically disubstituted ter‐ and quinquethiophenes and phenylene analogues are obtained via an efficient consecutive pseudo‐five‐component synthesis.
ChemInform Abstract: A Novel Method to Access Chiral Nonnatural 2,4‐Disubstituted Pyrrolidines from Aldehydes and Nitroolefins Only with an α‐Substituent.
Authors: Zheng Bo , Wang Hui , Han Yong , Liu Changlu , Peng Yungui 
Published: August 2013

Abstractγ‐Nitro carbonyl products (III) are obtained in good yields and stereoselectivities via the organocatalytic asymmetric Michael addition of nitroolefins (II) with aldehydes (I).
ChemInform Abstract: Enantioselective Synthesis of 4‐Aminopyrrolidine‐2,4‐dicarboxylate Derivatives via Ag‐Catalyzed Cycloaddition of Azomethine Ylides with Alkylidene Azlactones.
Authors: Gonzales‐Esguevillas Maria , Adrio Javier , Carretero Juan C. 
Published: August 2013

AbstractBy subsequent basic hydrolysis of the product′s ester groups the corresponding 4‐amidopyrrolidine‐2,4‐dicarboxylic acids are formed.
ChemInform Abstract: Aerobic Synthesis of Pyrroles and Dihydropyrroles from Imines: Palladium(II)‐Catalyzed Intramolecular C—H Dehydrogenative Cyclization.
Authors: Shi Zhuangzhi , Suri Mamta , Glorius Frank 
Published: August 2013

AbstractThe mild cyclization of imines to various pyrrole structures uses molecular oxygen as the sole stoichiometric oxidant.
ChemInform Abstract: Highly Enantioselective Organocatalytic Michael Addition/Cyclization Cascade Reaction of Ylideneoxindoles with Isothiocyanato Oxindoles: A Formal [3 + 2] Cycloaddition Approach to Optically Active Bispirooxindole Derivatives.
Authors: Tan Fen , Cheng Hong‐Gang , Feng Bin , Zou You‐Quan , Duan Shu‐Wen , Chen Jia‐Rong , Xiao Wen‐Jing 
Published: August 2013

AbstractThe title reaction allows the rapid construction of bispirooxindole skeletons bearing three contiguous stereogenic centers with two quaternary stereocenters in almost quantitative yields and with extraordinarily high enantio‐ and diastereoselectivities.
ChemInform Abstract: Synthesis of 1,2‐Diaryl‐1H‐indol‐4‐ols and 1,2‐Diaryl‐7‐ethoxy‐1,5,6,7‐tetrahydroindol‐4‐ones from Arylglyoxals and Enamines Through Domino Reactions.
Authors: Maity Subhendu , Pathak Sudipta , Pramanik Animesh 
Published: August 2013

AbstractBy a simple change of the solvent from acetonitrile to ethanol, different products can be obtained [cf.
ChemInform Abstract: A Three‐Component Palladium‐Catalyzed Oxidative C—C Coupling Reaction: A Domino Process in Two Dimensions.
Authors: Nimje Roshan Y. , Leskinen Mikko V. , Pihko Petri M. 
Published: August 2013

AbstractThe process tolerates a broad spectrum of substrates and the highly functionalized indole scaffolds are formed under mild conditions with excellent regioselectivity.
ChemInform Abstract: Enantioselective Iron‐Catalyzed Azidation of β‐Keto Esters and Oxindoles.
Authors: Deng Qing‐Hai , Bleith Tim , Wadepohl Hubert , Gade Lutz H. 
Published: August 2013

AbstractThe reaction is effective for the cyclic β‐ketoesters and 3‐oxindoles using azidoiodinane as an azide source.
ChemInform Abstract: Iodine‐Catalyzed Regioselective Sulfenylation of Indoles with Sulfonyl Hydrazides.
Authors: Yang Fu‐Lai , Tian Shi‐Kai 
Published: August 2013

AbstractAn unprecedented sulfenylation of indoles with sulfonyl hydrazides proceeds through the cleavage of the sulfur—oxygen and the sulfur—nitrogen bond.
ChemInform Abstract: Synthesis and Fungicidal Activity of 5‐Aryl‐1‐(aryloxyacetyl)‐3‐(tert‐butyl or phenyl)‐4‐(1H‐1,2,4‐triazol‐1‐yl)‐4,5‐dihydropyrazole.
Authors: Mao Hui‐Yu , Song Hong , Shi De‐Qing 
Published: August 2013

AbstractPreliminary bioassays indicate that some of the synthesized compounds display moderate to excellent fungicidal activity.
ChemInform Abstract: Synthesis of Chromones Through LiOtBu/Air‐Mediated Oxidation and Regioselective Cyclization of o‐Hdroxyphenyl Propargyl Carbinols.
Authors: Zhang Shuai , Wan Changfeng , Wang Qiang , Zhang Baiqun , Gao Lingfeng , Zha Zhenggen , Wang Zhiyong 
Published: August 2013

AbstractThe cascade oxidative cyclization reaction for the synthesis of chromones proceeds in the presence of LiO‐tBu as a mediator and air as an oxidant without the assistance of a transition metal.
ChemInform Abstract: Synthesis of 5‐(Trifluoromethyl)‐5H‐chromeno[3,4‐b]pyridines from 3‐Nitro‐2‐(trifluoromethyl)‐2H‐chromenes and Aminoenones Derived from Acetylacetone and Cyclic Amines.
Authors: Korotaev Vladislav Yu. , Barkov Alexey Yu. , Sosnovskikh Vyacheslav Ya. 
Published: August 2013

AbstractNucleophilic addition of enamines (II) to chromenes (I) furnishes products (III).
ChemInform Abstract: Highly Regioselective Assembly of Di‐ or Trisubstituted Pyridines from Arynes, Isocyanides, and 3‐Bromo‐ or 3‐Acetoxypropynes.
Authors: Sha Feng , Shen Hui , Wu Xin‐Yan 
Published: August 2013

AbstractThe reaction proceeds with high regioselectivity via a novel intramolecular pericyclization of the in situ generated key azatriene intermediates.
ChemInform Abstract: Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation of 1‐Aryl‐Substituted Dihydroisoquinolines: Access to Valuable Chiral 1‐Aryl‐Tetrahydroisoquinoline Scaffolds.
Authors: Wu Zi , Perez Marc , Scalone Michelangelo , Ayad Tahar , Ratovelomanana‐Vidal Virginie 
Published: August 2013

AbstractNotable features of the process include mild conditions, operational simplicity, high yields and enantioselectivities.
ChemInform Abstract: Light‐Induced Stereospecific Intramolecular [2 + 2]‐Cycloaddition of Atropisomeric 3,4‐Dihydro‐2‐pyridones.
Authors: Kumarasamy Elango , Sivaguru J. 
Published: August 2013

AbstractAtropisomeric pyridones (I) and (III) undergo stereospecific [2 + 2]‐cycloaddition in solution with high stereoselectivity.