bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extrapolation Of A Controversial Subject In Pregnancy And Puerperium: The Influence Of Combined Oral Contraceptive Use Over Body Mass Index And Biliary Symptoms
Authors: Tica Irina , Tica V.I. , Mihailov Claudia , Mitroi A. 
Published: February 2013

Abstract

Introduction and aim: Because for the majority of women one of the most unwanted effect of combined oral contraceptive use is considered to be weight increasement, our study aim was to find out if there is a correlation between the use of combined oral contraceptives in the present or past and the body mass index in a group of pregnant, puerperal and matching control patients.

Material, patients and method: In a prospective cohort (Regional University Hospital - Constanţa), 176 patients were included in 3 groups: pregnant, puerperal and matching non-pregnant women (control). For each patient a chart was considered, with the following parameters, age, height, weight, BMI, type of diet, use of combined oral contraceptives in the present or in the past (more than 6 months), ultrasound evaluation of gallbladder’ content.

Conclusion: In our study, the use of combined oral contraceptives was not correlated with a high BMI but it seems to correlate with a higher incidence of biliary dyspeptic symptoms in patients without biliary sludge or stones.
Emergence of Staphylococcus hominis Strains in General Infections
Authors: Voineagu Lavinia , Braga Victoria , Botnarciuc Mihaela , Barbu Adina , Tataru Mirela 
Published: February 2013

Abstract
A retrospective analysis of microbiology data from general infections was performed. From 105 isolates strains of Staphylococcus spp. 36 (34,28%) were Staphylococcus epidermidis, 33 (31,42%) Staphylococcus aureus, 21 (20%) Staphylococcus haemolyticus, and 15 (14,28%) were Staphylococcus hominis. Results: S. hominis isolates were predominantly resistant to betalactamins (93,33 %) and even Imidazole (60 %). 53,33 % of strains were resistent to aminosides and 33,33 % to Ciprofloxacin. All strains (100%) were sensitive to Vancomycin, but also all were susceptibile to Quinupristin-Dalfopristin. A high percentage of S. hominis were sensitive to Moxifloxacin, Linezolid (93,33 %), and to teicoplanin (86,67%). Discussion: S. hominis is a member of skin normal flora, but all strains of S. hominis were isolated from generalized infection with a high rate of mortality.
A case of acute leukaemia in a 38-years old female
Authors: Adina Barbu 
Published: February 2013

Abstract
Leukaemia is cancer that starts in blood-forming tissues, such as bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the bloodstream. The stem cells usually develop into a type of white blood cell called myeloblasts which do not mature into healthy white blood cells. The leukaemia cells are unable to do their usual work and can build up in the blood and bone marrow so there is less space for healthy white blood cells, red blood cells and platelets. Anemia is a major sign but diagnosis is provided only microscopic examination of peripheral blood smear.
Research on the diagnosis of peritoneal micrometastases in tumors of the subdiaphragmatic digestive tract
Authors: Ciufu N. , Vieru Alina , Costea D.O. 
Published: February 2013

Abstract
This presentation is aimed at analyzing the possibility of detecting the peritoneal micrometastases through multiple peritoneal biopsies to the patients with tumors of the subdiaphragmatic digestive tract.
Nowadays, detection of the micrometastases is performed indirectly through cytological analysis and / PCR analysis of the peritoneal liquid, through the histopathological study of the peritoneal fragments intraoperatively collected and the immunohistochemical study.
This presentation is aimed at analyzing the possibility of detecting the peritoneal micrometastases through multiple peritoneal biopsies and to correlate this with various factors such us: staging neoplasia, the affected organ, histopathological type, tumoral grading.
Inclusion of the patients that find themselves in the early stage of peritoneal carcinomatosis - of peritoneal micrometastases - would allow for the application of an adequate treatment and could greatly increase the patient’s survival chances
Capsule endoscopy – accurate diagnosis method for detection of obscure digestive bleedings and secondary chronic anemia
Authors: Suceveanu A.P. , Suceveanu Andra-Iulia , Mazilu Laura , Parepa Irinel-Raluca , Voinea F. 
Published: February 2013

Abstract
Background. Capsule endoscopy is a revolutionary new diagnostic method for the detection of digestive diseases, especially localized at the level of small bowel and colorectal tract. This method is the only technique that allows endoscopic examination of the digestive tract without sedation. Obscure gastrointestinal bleeding is the most common indication for capsule endoscopy, which commonly diagnoses arteriovenous malformations, small bowel tumors, ulcers or tumors missed at standard endoscopy or other imaging examinations [1]. Aim. Our study aimed to detect the accuracy of endoscopic videocapsule in detecting the cause of microscopic anemia in patients with supposed digestive pathologies. Material and method. We used PillCam 2 Platform provided by Given Imaging, a system consisting of PillCam 2 videocapsules, a data recorder, a set of sensors and the Rapid 7 Access computer soft capable to receive and transform pictures into films, in order to visualize the entire digestive gastrointestinal tract. We examined 25 patients with chronic anemia, all of them without any known hematologic, renal or digestive disease, investigated by standard imagistic and lab techniques. Results. From the total of 25 investigated patients, 18 (72%) of them presented sources of bleeding discovered with videocapsule endoscopy. The source of bleeding was the small bowel in 10 cases (55%) and the colorectal tract in 8 cases (45%). The accuracy of videocapsule was very good for detecting the digestive tract obscure sources of bleeding (Sn=74%, Sp=87%). Conclusions. The videocapsule endoscopy is an accurate imagistic option to detect digestive sources of bleeding and to identify the cause of many chronic anemia
Daily noise exposure effects on serum transaminases
Authors: Chirică R. , Comșa G.I. 
Published: February 2013

Abstract
Noise pollution is one of the biggest problems that europeans is facing in our days. Half of europeans live in a permanent noise and one third suffer from insomnia due to noise pollution. Also, besides affecting social life, exposure to noise can cause changes in the organs, and it can be a triggering cause disease.
Water and nitrate movements in an agricultural field with different soil frost depths: field experiments and numerical simulation
Authors: Iwata Yukiyoshi , Yazaki Tomotsugu , Suzuki Shinji , Hirota Tomoyoshi 
Published: February 2013

AbstractTo evaluate water and anion movement in an agricultural field in different frost conditions, a paired-plot field experiment was conducted at an agricultural site in northern Japan where a significant decrease in the frost depth has occurred during the past 20 years. Snow cover was removed to enhance soil freezing in one plot (treated plot), whereas natural conditions were maintained in a control plot. The maximum frost depth was 0.43 m in the treated plot and 0.11 m in the control plot, which induced substantial differences in water movement throughout the winter. A substantial amount of water moved upward before the onset of snowmelt. However, nitrate did not move markedly before the snowmelt period in either plot. The amount of snowmelt infiltration in the control plot was larger than in the treated plot. Correspondingly, the peak of nitrate content in the control plot was deeper than that in the treated plot after the snowmelt period. Soil freezing, snow accumulation and snowmelt processes were simulated reasonably well using a one-dimensional numerical model: Simultaneous Heat and Water (SHAW). Nevertheless, the model performed poorly for simulating soil thawing and soil water movement, suggesting a need for improvement.
The contribution of the Vaccine adverse event Text Mining system to the classification of possible Guillain-Barré Syndrome reports
Authors: Woo E. J. , Ball R. , Botsis T. 
Published: February 2013

Summary
Background: We previously demonstrated that a general purpose text mining system, the Vaccine adverse event Text Mining (VaeTM) system, could be used to automatically classify reports of anaphylaxis for post-marketing safety surveillance of vaccines.
Objective: To evaluate the ability of VaeTM to classify reports to the Vaccine Adverse Event Reporting System (VAERS) of possible Guillain-Barré Syndrome (GBS).
Methods: We used VaeTM to extract the key diagnostic features from the text of reports in VAERS. Then, we applied the Brighton Collaboration (BC) case definition for GBS, and an information retrieval strategy (i.e. the vector space model) to quantify the specific information that is included in the key features extracted by VaeTM and compared it with the encoded information that is already stored in VAERS as Medical Dictionary for Regulatory Activities (MedDRA) Preferred Terms (PTs). We also evaluated the contribution of the primary (diagnosis and cause of death) and secondary (second level diagnosis and symptoms) diagnostic VaeTM-based features to the total VaeTM-based information.
Results: MedDRA captured more information and better supported the classification of reports for GBS than VaeTM (AUC: 0.904 vs. 0.777); the lower performance of VaeTM is likely due to the lack of extraction by VaeTM of specific laboratory results that are included in the BC criteria for GBS. On the other hand, the VaeTM-based classification exhibited greater specificity than the MedDRA-based approach (94.96% vs. 87.65%). Most of the VaeTM-based information was contained in the secondary diagnostic features.
Conclusion: For GBS, clinical signs and symptoms alone are not sufficient to match MedDRA coding for purposes of case classification, but are preferred if specificity is the priority.
Citation: Botsis T, Woo EJ, Ball R. The contribution of the vaccine adverse event text mining system to the classification of possible Guillain-Barré syndrome reports. Appl Clin Inf 2013; 4: 88–99http://dx.doi.org/10.4338/ACI-2012-11-RA-0049
Routine Intraoperative Transesophageal Echocardiography: Impact on Intraoperative Surgical Decision Making, a Single Center Interim Analysis
Authors: Badamali Ashok Kumar , Madhavan J Sethu , Ghuman BPS , Subash S , Mishra Abhi , Mishra Ajay , Arya VK , Kumar Bhupesh , Jayant Aveek , Shyam KST , Rana Sandeep Singh , Kuthe Sachin , Mahajan Sachin , Prasad Shiva , Mathew Sarin , Arora Inderjeet 
Published: February 2013

ABSTRACTTransesophageal echocardiography (TEE) has become an important part of armamentarium for anesthesiologists in the management of patients undergoing cardiac surgery. Many studies have demonstrated the safety and utility of TEE in cardiac surgery. With advances in hardware and software, easy availability of resources for learning and optimal understanding of image generation and interpretation, many new findings crop up in the operating room (OR) which may have been missed in preoperative transthoracic echocardiography (TTE), leading to necessary changes in planned surgical procedure. In our retrospective analysis of 726 cases in which TEE was performed over the last 1 year, changes in decision was made in 65 (8.9%) of cases. This included 42 unanticipated findings prior to cardiopulmonary bypass and 23 new findings after CPB, requiring revision in 15 cases. With the increasing use and further impending advances of TEE, the number of cases in which surgical decision will be altered may increase in near future.How to cite this articleBadamali AK, Madhavan JS, Ghuman BPS, Subash S, Raj R, Mishra A, Mishra A, Arya VK, Kumar B, Jayant A, Shyam KST, Rana SS, Singh H, Mishra A, Kuthe S, Mahajan S, Prasad S, Mathew S, Arora I, Puri GD. Routine Intraoperative Transesophageal Echocardiography: Impact on Intraoperative Surgical Decision Making, a Single Center Interim Analysis. J Perioper Echocardiogr 2013;1(1):16-20.
Acquired thrombotic thrombocytopenic purpura
Authors: Studt J.-D. , Voorberg J. , Hovinga J. A. Kremer , Schaller M. 
Published: February 2013

SummaryThe von Willebrand factor (VWF)-cleaving metalloprotease, ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motifs-13) is the only known target of the dysregulated immune response in acquired TTP. Autoantibodies to ADAMTS13 either neutralize its activity or accelerate its clearance, thereby causing a severe deficiency of ADAMTS13 in plasma. As a consequence, size regulation of VWF is impaired and the persistence of ultra-large VWF (ULVWF) multimers facilitates micro vascular platelet aggregation causing microangiopathic haemolytic anaemia and ischaemic organ damage. Autoimmune TTP although a rare disease with an annual incidence of 1.72 cases has a mortality rate of 20% even with adequate therapy.We describe the mechanisms involved in ADAMTS13 autoimmunity with a focus on the role of B- and T-cells in the pathogenesis of this disorder. We discuss the potential translation of recent experimental findings into future therapeutic concepts for the treatment of acquired TTP.
Accéder au meilleur quartier possible : types de famille et ségrégation résidentielle croisée à Montréal
Authors: Pelletier David 
Published: February 2013

Le sujet principal de ce texte est une forme très ciblée de ségrégation démographique : la ségrégation des familles avec enfants selon leur type. Cependant, puisque la répartition spatiale des familles avec couple marié, avec couple en union libre, monoparentales à chef féminin et monoparentales à chef masculin ne dépend pas uniquement de leur structure, il faut aussi considérer d’autres facettes de leur identité, notamment leurs caractéristiques socioéconomiques et ethnoculturelles. La combinaison de ces facteurs engendre une ségrégation croisée que nous explorons avec les microdonnées du recensement de 2006 pour la région métropolitaine de Montréal. Nous utilisons d’abord des indices de ségrégation pour mettre en évidence une ségrégation familiale « brute », puis nous avons recours à des modèles de locational attainment pour déterminer l’effet « net » du type de famille sur le revenu médian du quartier de résidence. Nous trouvons qu’il existe une interaction importante entre l’appartenance ethnoculturelle et le type de famille, ce qui nous conduit à relativiser les résultats de recherches qui ne prennent pas en compte l’hétérogénéité interne des types de famille.
Dans les pas des recenseurs : une analyse critique des dimensions géographiques et familiales du recensement canadien de 1852
Authors: Dillon Lisa , Joubert Katrina 
Published: February 2013

Le premier recensement nominatif canadien du xixe siècle, celui de 1851-1852 pour le Canada-Est et le Canada-Ouest, représente une occasion unique de comprendre les comportements sociaux observés à cette époque. Cette analyse approfondie, axée sur un échantillon aléatoire de 20 %, relativise les critiques formulées à son encontre : les données provenant des manuscrits témoignent d’un dénombrement principalement (mais pas toujours) systématique. Relativement peu de recenseurs ont utilisé les marques « ditto » ou les totaux au lieu des marques unitaires par individu, peu également ont attribué plus d’un statut familial à chaque personne. Les membres des familles nucléaires, les parents du chef de ménage et les domestiques ont été classés, dans la plupart des cas, de façon uniforme d’un recenseur à l’autre. L’absence d’un tiers des manuscrits du recensement de 1852 pose un plus grand défi, mais notre échantillon est néanmoins représentatif de la population à l’échelle de la province en égard au sexe, à l’âge et à l’état matrimonial.
Trajectoires conjugales des parents et rendement scolaire des enfants en première année du primaire
Authors: Lardoux Solène , Pelletier David 
Published: February 2013

Dans la société québécoise, l’union libre est devenue une alternative au mariage comme cadre de formation des familles. Cependant, très peu de recherches ont comparé le développement des enfants de parents en union libre et de parents mariés. De même, les effets de la séparation d’une union libre et d’un mariage ont rarement été distingués les uns des autres. Avec un échantillon représentatif de 1 347 enfants provenant de l’Étude longitudinale du développement des enfants du Québec (ÉLDEQ), nous nous intéressons aux liens entre l’état matrimonial des parents à la naissance de l’enfant, la survenue d’une rupture conjugale et le rendement scolaire des enfants en première année du primaire (évalué par l’enseignant et par des tests cognitifs). Le rôle modérateur du genre est aussi examiné. Contrairement à ce que constatent les chercheurs américains, nous ne trouvons pas d’association négative entre une naissance en union libre et le rendement scolaire au Québec. Nous identifions plutôt de faibles associations positives pour les filles. Enfin, la séparation des parents est parfois liée à un plus faible rendement scolaire, mais cette relation varie selon l’état matrimonial à la naissance et le genre de l’enfant.
Mechanisms for High‐Performance and Non‐Local Photoisomerization Gratings in a Sol–Gel Material
Authors: Gallego‐Gómez Francisco , del Monte Francisco , Meerholz Klaus 
Published: February 2013

AbstractNovel azo‐containing sol–gel films exhibiting outstanding properties for optical applications via nonlocal photoisomerization gratings were reported recently, although the underlying mechanisms were not well understood, especially regarding the unexpected non‐local effect. Here, this photoisomerizable sol–gel material is characterized in‐depth, analyzing the design and fabrication strategy, and discussing the aspects that enable the efficient photoresponse, with focus on the holographic recording. The material consists of an azochromophore‐rich silica matrix containing glycidoxypropyl groups, which provide increased flexibility and internal free volume for improved dye photoresponse. The matrix characteristics allow a novel procedure for fabrication of thick optical films, in which chromophore aggregation is ruptured by thermal annealing while keeping the material centrosymmetry (beneficial for high hologram contrast). The molecular photo‐orientation promotes alignment of microscopic domains in a cooperative motion, not reported previously in sol–gel materials. This collective mechanism enhances the material response and explains some intriguing features of photoisomerization gratings. In particular, there is evidence that spatially shifted domains are related to the grating nonlocal nature. Different recording (write–erase–write) procedures that distinctly affect the photoalignment at both molecular and microscopic level are studied. The holographic performance drastically changes, which can be selectively exploited for either long‐term or dynamic holography.
Immobilization of Quantum Dots in Nanostructured Porous Silicon Films: Characterizations and Signal Amplification for Dual‐Mode Optical Biosensing
Authors: Gaur Girija , Koktysh Dmitry S. , Weiss Sharon M. 
Published: February 2013

AbstractHighly sensitive dual‐mode labeled detection of biotin in well‐characterized porous silicon (PSi) films using colloidal quantum dots (QDs) as signal amplifiers are demonstrated. Optimization of the PSi platform for targeted QD infiltration and immobilization is carried out by characterizing and tuning the porosity, film depth, and pore size. Binding events of target QD‐biotin conjugates with streptavidin probes immobilized on the pore walls are monitored by reflective interferometric spectroscopy and fluorescence measurements. QD labeling of the target biotin molecules enables detection based on a distinct fluorescent signal as well as a greater than 5‐fold enhancement in the measured spectral reflectance fringe shift and a nearly three order of magnitude improvement in the detection limit for only 6% surface area coverage of QDs inside the porous matrix. Utilizing the QD signal amplifiers, an exceptional biotin detection limit of ≈6 fg mm−2 is demonstrated with sub‐fg mm−2 detection limits achievable.
Pretibial linear vertical creases or indentations (shin dimples) associated with arthrogryposis
Authors: Hall Judith G. 
Published: February 2013

AbstractAmong 2,500 cases of arthrogryposis, 14 families and 17 individuals were identified that had a linear vertical crease (indentation/dimple) along the anterior tibia, usually bilaterally. Approximately half had developmental delay/intellectual disability and the others had normal intellectual development. There are generalized flexion contractures with the legs more severely affected than the arms. The ankles are flexed at birth suggesting a relationship of contraction of the anterior tibial compartment to the in utero development of the anterior tibial crease. Dislocated hips are seen in 60%. Hands open with physical therapy and become quite functional. Those with normal intelligence are ambulatory, often with a crouching stance. Three families had recurrence suggesting a recessive pattern of inheritance. All parents were normal. No affected individuals have had offspring. Several have had CGH arrays, which were normal. The presence of this crease in cases of arthrogryposis appears to be a helpful clinical observation and may even be pathognomonic. © 2013 Wiley Periodicals, Inc.
Barriers for integrating personalized medicine into clinical practice: A qualitative analysis
Authors: Najafzadeh Mehdi , Davis Jennifer C. , Joshi Pamela , Marra Carlo 
Published: February 2013

AbstractPersonalized medicine—tailoring interventions based on individual's genetic information—will likely change routine clinical practice in the future. Yet, how practitioners plan to apply genetic information to inform medical decision making remains unclear. We aimed to investigate physician's perception about the future role of personalized medicine, and to identify the factors that influence their decision in using genetic testing in their practice. We conducted three semi‐structured focus groups in three health regions (Fraser, Vancouver coastal, and Interior) in British Columbia, Canada. In the focus groups, participants discussed four topics on personalized medicine: (i) physicians' general understanding, (ii) advantages and disadvantages, (iii) potential impact and role in future clinical practice, and (iv) perceived barriers to integrating personalized medicine into clinical practice. Approximately 36% (n = 9) of physicians self‐reported that they were not familiar with the concept of personalized medicine. After introducing the concept, the majority of physicians (68%, n = 19 of 28) were interested in incorporating personalized medicine in their practice, provided they have access to the necessary knowledge and tools. Participants mostly believed that genetic developments will directly affect their practice in the future. The key concerns highlighted were physician's access to clinical guidelines and training opportunities for the use of genetic testing and data interpretation. Despite the challenges that personalized medicine can create, in general, physicians in the focus groups expressed strong interest in using genetic information in their practice if they have access to the necessary knowledge and tools. © 2013 Wiley Periodicals, Inc.