bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Correlation between Follicular Fluid Antimullerian Hormone Levels and Fertilization and Embryo Quality in ART Cycles
Authors: Dalal Rutvij Jay , Mishra Akansha 
Published: March 2013

ABSTRACTBackgroundDetermination of oocyte and embryo quality are one of the most important goals inin vitrofertilization (IVF). Antimullerian hormone (AMH) is secreted by the ovarian granulosa cells into blood flow and follicular fluid. Follicular fluid (FF) AMH level is probably a marker of activity of granulosa cells.ObjectiveTo evaluate whether high level of FF AMH level is related to success of fertilization and better embryo quality.Materials and methodsSixty-two women, whose FF sample was obtained from a single follicle in each patient, underwent IVF with GnRH-agonist long protocol. Based on oocyte fertilization, the patients were divided into fertilized group (n = 42) and nonfertilized group (n = 20). FF AMH levels were measured in both groups and the quality of embryos was determined in fertilized group.ResultsMedian of FF AMH level in fertilized group was higher than that in nonfertilized group (5.7vs2.7 ng/ml) and a statistically significant difference was observed between the two groups. There was a significant difference between FF AMH level and scores of embryos (p < 0.001). The medians levels of FF AMH were 6.7 ng/ml in good quality embryos and 3.80 ng/ml in fair quality embryos.ConclusionOur results indicate that FF AMH level has positive correlation with fertilization and embryo quality; therefore, it can be considered as a marker of IVF outcome.How to cite this articleDalal RJ, Mishra A. The Correlation between Follicular Fluid Antimullerian Hormone Levels and Fertilization and Embryo Quality in ART Cycles. Int J Infertility Fetal Med 2012;3(3):83-86.
Successful Obstetrical Management of Over 100-day Interval between the First and Second Twin Delivery in an Infertility-Treated Patient: Counseling and Management Approach to Extreme Asynchronous Twin
Authors: Singh Tejshree Anurag , Majumdar Abha 
Published: March 2013

ABSTRACTBackgroundThis report describes a patient counseling approach, conservative and surgical management (cervical cerclage) of a dichorionic-diamniotic twin pregnancy, where delivery of the second twin followed the delivery of the first by 104 days.Case presentationA 35-year-old Indian lady, with 10 years of primary infertility, conceived twins, following ovulation induction with gonadotropin therapy. At 19 weeks and 4 days gestation, she aborted a female fetus of 410 gm. Tocolytic therapy was initiated; the placenta remainedin situand the umbilical cord of twin A was ligated high and McDonald's cerclage was placed and prophylactic antibiotics initiated. But since the patient's uterus continued to be irritable and the cerclage appeared to be under tension, at 20 weeks 6 days the stitch was taken out and all conservative treatment stopped for 24 hours, but reinitiated after this period, since the uterus remained quiescent. After 3 weeks of uterine inactivity, at 23 weeks 6 days gestation, McDonald's suture was reapplied following which conservative management was offered after counseling for possible risks associated with maternal sepsis, coagulopathy, need for extended hospitalization and potential for hysterectomy. Reassuring fetal status was observed for twin B without evidence of contractions or chorioamnionitis. A viable male infant (1,800 gm) was delivered vaginally at 34 weeks and 4 days gestation.ConclusionThis report outlines a counseling approach useful for patients with premature delivery of one twin, and presents application of conservative obstetrical management principles for the aftercoming twin, even when delivery interval is extreme.How to cite this articleSingh TA, Majumdar A. Successful Obstetrical Management of Over 100-day Interval between the First and Second Twin Delivery in an Infertility-Treated Patient: Counseling and Management Approach to Extreme Asynchronous Twin. Int J Infertility Fetal Med 2012;3(3): 97-101.
The Results of Switching between 2 Anti-VEGF Drugs, Bevacizumab and Ranibizumab, in the Treatment of Neovascular Age-related Macular Degeneration
Authors: Aslankurt Murat , Aslan Lokman , Aksoy Adnan , Erden Burak , Çekiç Osman 
Published: March 2013

Purpose To report the results of switching from intravitreal bevacizumab to ranibizumab or vice versa in the treatment of choroidal neovascularization (CNV) due to age-related macular degeneration. Methods Twenty eyes of 18 patients that underwent switch from intravitreal bevacizumab to ranibizumab and 10 eyes of 8 patients that underwent switch from ranibizumab to bevacizumab were retrospectively analyzed. The results were compared with 41 eyes of 37 patients treated with ranibizumab only. All eyes initially received 3 injections of ranibizumab or bevacizumab, which were repeated as needed (PRN dosing). Anti–vascular endothelial growth factor therapies were switched because of general health insurance applications and cost problems. The main outcome measures were best-corrected visual acuity (BCVA), injection number, and central macular thickness (CMT) obtained by optical coherence tomography. Results Once all patients evaluated together at the final visit, the mean BCVA improved and CMT decreased. When switching groups were taken into consideration, switching yielded improved BCVA and reduced CMT following switching. After switching, BCVA continuously improved in the bevacizumab to ranibizumab group, but stayed stable in the ranibizumab to bevacizumab group. The CMT was reduced at the switching time in both groups, but did not change after the switch. Final visual acuity improved or stabilized in all eyes in the ranibizumab-only group. The BCVA worsened in 20% of eyes in the bevacizumab to ranibizumab group and in 40% of eyes in the ranibizumab to bevacizumab group. Conclusions The ranibizumab-only group and the switching from bevacizumab to ranibizumab group seemed superior to the ranibizumab to bevacizumab group.
Corneal Biomechanical Properties and their Correlates with Healing Process after Descemetic versus Pre-Descemetic Lamellar Keratoplasty
Authors: Abdelkader Almamoun 
Published: March 2013

Purpose To evaluate the influence of the wound-healing process on corneal biomechanics in patients after 2 types of deep anterior lamellar keratoplasty: Descemetic with total stromal resection vs pre-Descemetic with deep stromal dissection. Methods This prospective comparative study consisted of 32 eyes of 32 patients. Patients were divided into 2 groups: Descemetic (17 eyes) and pre-Descemetic (15 eyes). Reichert ocular response analyzer was used to measure corneal hysteresis (CH) and corneal resistance factor (CRF) at 1 and 3 months postoperatively. Central corneal thickness (CCT) was measured using ultrasonic pachymetry. In vivo confocal microscopy was also used to study the corneal wound-healing process and to correlate these events with the corneal biomechanics postoperatively in both groups. Results Both mean CH and mean CRF were significantly lower in the Descemetic than the pre-Descemetic group at 1 and 3 months postoperatively (p≤0.0001). The reflectivity of activated keratocytes at both the interface and wound edge was less in the Descemetic than the pre-Descemetic group at all times as revealed by the confocal microscopy. No statistically significant difference in mean CCT was found between both groups at 1 and 3 months. Subsequent and progressive decrease in interface reflectivity of activated keratocytes was presented in both groups. Conclusions Healing process at the interface is key to optimal corneal integrity. In the pre-Descemetic group, stroma-to-stroma healing stimulated more activated keratocytes and hence stronger healing response, providing superior corneal biomechanics. Significant positive correlation between the intensity of the keratocyte activation and corneal integrity was found.
Verifying stabilizing controllers for performance improvement using closed‐loop data
Authors: Cha Sung H. , Dehghani Arvin , Chen Weitian , Anderson Brian D.O. 
Published: March 2013

SUMMARYIn iterative identification and control, one needs to determine the closed‐loop performance of a new controller designed with the current model so that a decision can be made on whether a new iteration of plant identification and controller design is necessary. In multiple model adaptive control, at times, a decision to connect a different controller is made. It is desirable to check the closed‐loop performance with a new controller before it is switched in. Consider a feedback interconnection of an unknown linear plant and a known linear stabilizing controller, and assume that some knowledge of the closed‐loop system is available. We aim to develop theory and tools for experimentally verifying the closed‐loop performance with a prospective stabilizing controller in advance. The simulation results demonstrate efficacy and versatility of our results.Copyright © 2013 John Wiley & Sons, Ltd.
Sliding‐window hybrid quasi‐Newton algorithm‐trained MBER equalisers
Authors: Zhu Renxiang , Wu Lenan 
Published: March 2013

SUMMARYNonlinear equalisers based on minimum BER are proposed for the equalisation of nonlinear time‐varying channels. To train the equalisers online, a sliding‐window‐based hybrid quasi‐Newton algorithm is proposed. Switching between sliding‐window stochastic gradient algorithm and sliding‐window quasi‐Newton algorithm makes the new algorithm significantly stabler with a fast convergence rate. Results from extensive simulation tests show that performance of nonlinear equalisers based on minimum BER is better than the equaliser based on minimum mean square error. The proposed algorithm demonstrates high efficiency as well. Copyright © 2013 John Wiley & Sons, Ltd.
Synchrotron X‐Ray Scanning Tunneling Microscopy: Fingerprinting Near to Far Field Transitions on Cu(111) Induced by Synchrotron Radiation
Authors: Rose Volker , Wang Kangkang , Chien TeYu , Hiller Jon , Rosenmann Daniel , Freeland John W. , Preissner Curt , Hla Saw‐Wai 
Published: March 2013

AbstractThe combination of the high spatial resolution of scanning tunneling microscopy with the chemical and magnetic contrast provided by synchrotron X‐rays has the potential to allow a unique characterization of advanced functional materials. While the scanning probe provides the high spatial resolution, synchrotron X‐rays that produce photo‐excitations of core electrons add chemical and magnetic contrast. However, in order to realize the method's full potential it is essential to maintain tunneling conditions, even while high brilliance X‐rays irradiate the sample surface. Different from conventional scanning tunneling microscopy, X‐rays can cause a transition of the tip out of the tunneling regime. Monitoring the reaction of the z‐piezo (the element that controls the tip to sample separation) alone is not sufficient, because a continuous tip current is obtained. As a solution, an unambiguous and direct way of fingerprinting such near to far field transitions of the tip that relies on the simultaneous analysis of the X‐ray‐induced tip and sample current is presented. This result is of considerable importance because it opens the path to the ultimate resolution in X‐ray enhanced scanning tunneling microscopy.
Nanomaterial‐Based Fluorescent DNA Analysis: A Comparative Study of the Quenching Effects of Graphene Oxide, Carbon Nanotubes, and Gold Nanoparticles
Authors: Li Fan , Pei Hao , Wang Lihua , Lu Jianxin , Gao Jimin , Jiang Bowei , Zhao Xingchun , Fan Chunhai 
Published: March 2013

AbstractA variety of nanomaterials have shown extraordinarily high quenching ability toward a broad range of fluorophores. Recently, there has been intense interest in developing new tools for fluorescent DNA analysis in solution or inside the cell based on this property, and by exploiting interactions between these nanoscale “superquenchers” and DNA molecules in the single‐stranded (ss‐) or double‐stranded (ds‐) forms. Here, a comparative study on the nanoqueching effects is performed by using a series of nanomaterials with different dimensions, i.e., gold nanoparticles (AuNPs, 0D), carbon nanotubes (CNTs, 1D), and graphene oxide (GO, 2D). The quenching efficiency, kinetics, differentiation ability, and influencing factors such as concentration and ionic strength are studied. Interestingly, GO exhibits superior quenching abilities to the other two materials in both the quenching efficiency and kinetics. As a result, a GO‐based fluorescent sensor, designed in a simple mix‐and‐detect format, can detect concentrations of DNA as low as 0.2 nM, which is better than either CNTs or AuNPs by an order of magnitude. This sensor can also differentiate single‐base mismatches much better than either CNTs‐ or AuNPs‐ based sensors. This study paves the way to better choice of nanomaterials for bioanalysis and elaborate design of biosensors for both in vitro diagnosis and in vivo bioimaging.
Nano‐Graphene Oxide: A Potential Multifunctional Platform for Cancer Therapy
Authors: Gonçalves Gil , Vila Mercedes , Portolés María‐Teresa , Vallet‐Regi María , Gracio José , Marques Paula Alexandrina A. P. 
Published: March 2013

AbstractNano‐GO is a graphene derivative with a 2D atomic layer of sp2 bonded carbon atoms in hexagonal conformation together with sp3 domains with carbon atoms linked to oxygen functional groups. The supremacy of nano‐GO resides essentially in its own intrinsic chemical and physical structure, which confers an extraordinary chemical versatility, high aspect ratio and unusual physical properties. The chemical versatility of nano‐GO arises from the oxygen functional groups on the carbon structure that make possible its relatively easy functionalization, under mild conditions, with organic molecules or biological structures in covalent or non‐covalent linkage. The synergistic effects resulting from the assembly of well‐defined structures at nano‐GO surface, in addition to its intrinsic optical, mechanical and electronic properties, allow the development of new multifunctional hybrid materials with a high potential in multimodal cancer therapy. Herein, a comprehensive review of the fundamental properties of nano‐GO requirements for cancer therapy and the first developments of nano‐GO as a platform for this purpose is presented.
The “Secret” in Secretions: Methodological Considerations in Deciphering Primate Olfactory Communication
Authors: DREA CHRISTINE M. , BOULET MARYLÈNE , DELBARCO‐TRILLO JAVIER , GREENE LYDIA K. , SACHA CAITLIN R. , GOODWIN THOMAS E. , DUBAY GEORGE R. 
Published: March 2013

AbstractOlfactory communication in primates is gaining recognition; however, studies on the production and perception of primate scent signals are still scant. In general, there are five tasks to be accomplished when deciphering the chemical signals contained in excretions and secretions: (1) obtaining the appropriate samples; (2) extracting the target organic compounds from the biological matrix; (3) separating the extracted compounds from one another (by gas chromatography, GC or liquid chromatography, LC); (4) identifying the compounds (by mass spectrometry, MS and associated procedures); and (5) revealing biologically meaningful patterns in the data. Ultimately, because some of the compounds identified in odorants may not be relevant, associated steps in understanding signal function involve verifying the perception or biological activity of putative semiochemicals via (6) behavioral bioassays or (7) receptor response studies. This review will focus on the chemical analyses and behavioral bioassays of volatile, primate scent signals. Throughout, we highlight the potential pitfalls of working with highly complex, chemical matrices and suggest ways for minimizing problems. A recurring theme in this review is that multiple approaches and instrumentation are required to characterize the full range of information contained in the complex mixtures that typify primate or, indeed, many vertebrate olfactory cues. Only by integrating studies of signal production with those verifying signal perception will we better understand the function of olfactory communication. Am. J. Primatol. 75:621–642, 2013. © 2013 Wiley Periodicals, Inc.
Population Density of Red Langurs in Sabangau Tropical Peat‐Swamp Forest, Central Kalimantan, Indonesia
Authors: EHLERS SMITH DAVID A. , EHLERS SMITH YVETTE C. 
Published: March 2013

AbstractBecause of the large‐scale destruction of Borneo's rainforests on mineral soils, tropical peat‐swamp forests (TPSFs) are increasingly essential for conserving remnant biodiversity, particularly in the lowlands where the majority of habitat conversion has occurred. Consequently, effective strategies for biodiversity conservation are required, which rely on accurate population density and distribution estimates as a baseline. We sought to establish the first population density estimates of the endemic red langur (Presbytis rubicunda) in Sabangau TPSF, the largest remaining contiguous lowland forest‐block on Borneo. Using Distance sampling principles, we conducted line transect surveys in two of Sabangau's three principle habitat sub‐classes and calculated group density at 2.52 groups km−2(95% CI 1.56–4.08) in the mixed‐swamp forest sub‐class. Based on an average recorded group size of 6.95 individuals, population density was 17.51 ind km−2, the second highest density recorded in this species. The accessible area of the tall‐interior forest, however, was too disturbed to yield density estimates representative of the entire sub‐class, andP. rubicundawas absent from the low‐pole forest, likely as a result of the low availability of the species' preferred foods. This absence in 30% of Sabangau's total area indicates the importance of in situ population surveys at the habitat‐specific level for accurately informing conservation strategies. We highlight the conservation value of TPSFs forP. rubicundagiven the high population density and large areas remaining, and recommend 1) quantifying the response ofP. rubicundato the logging and burning of its habitats; 2) surveying degraded TPSFs for viable populations, and 3) effectively delineating TPSF sub‐class boundaries from remote imagery to facilitate population estimates across the wider peat landscape, given the stark contrast in densities found across the habitat sub‐classes of Sabangau. Am. J. Primatol. 75:837–847, 2013. © 2013 Wiley Periodicals, Inc.
Indian ocean crossroads: Human genetic origin and population structure in the maldives
Authors: Pijpe Jeroen , de Voogt Alex , van Oven Mannis , Henneman Peter , van der Gaag Kristiaan J. , Kayser Manfred , de Knijff Peter 
Published: March 2013

ABSTRACTThe Maldives are an 850 km‐long string of atolls located centrally in the northern Indian Ocean basin. Because of this geographic situation, the present‐day Maldivian population has potential for uncovering genetic signatures of historic migration events in the region. We therefore studied autosomal DNA‐, mitochondrial DNA‐, and Y‐chromosomal DNA markers in a representative sample of 141 unrelated Maldivians, with 119 from six major settlements. We found a total of 63 different mtDNA haplotypes that could be allocated to 29 mtDNA haplogroups, mostly within the M, R, and U clades. We found 66 different Y‐STR haplotypes in 10 Y‐chromosome haplogroups, predominantly H1, J2, L, R1a1a, and R2. Parental admixture analysis for mtDNA‐ and Y‐haplogroup data indicates a strong genetic link between the Maldive Islands and mainland South Asia, and excludes significant gene flow from Southeast Asia. Paternal admixture from West Asia is detected, but cannot be distinguished from admixture from South Asia. Maternal admixture from West Asia is excluded. Within the Maldives, we find a subtle genetic substructure in all marker systems that is not directly related to geographic distance or linguistic dialect. We found reduced Y‐STR diversity and reduced male‐mediated gene flow between atolls, suggesting independent male founder effects for each atoll. Detected reduced female‐mediated gene flow between atolls confirms a Maldives‐specific history of matrilocality. In conclusion, our new genetic data agree with the commonly reported Maldivian ancestry in South Asia, but furthermore suggest multiple, independent immigration events and asymmetrical migration of females and males across the archipelago. Am J Phys Anthropol 151:58–67, 2013. © 2013 Wiley Periodicals, Inc.
JC virus antibody status underestimates infection rates
Authors: Berger Joseph R. , Houff Sidney A. , Gurwell Julie , Vega Nubia , Miller Craig S. , Danaher Robert J. 
Published: March 2013

ObjectiveJC virus (JCV) seropositivity is a risk factor for progressive multifocal leukoencephalopathy (PML) in patients on natalizumab. Accordingly, the JCV serological antibody test is of paramount importance in determining disease risk.MethodsWe tested the accuracy of the JCV serum antibody test by comparing the results of JCV serology to JCV viruria and viremia in 67 patients enrolled in a single‐center, retrospective cohort study. Bodily fluids (urine and blood) were assessed for JCV DNA by real time quantitative polymerase chain reaction 6 to 47 months (mean = 26.1 months) before JCV antibody testing. In 10 individuals, blood and urine samples were obtained on 2 separate occasions at 6‐month intervals.ResultsForty (59.7%) of the 67 patients were JCV seropositive. Of 27 JCV seronegative patients, 10 (37%) had JCV viruria. Urine JCV DNA copy numbers were significantly higher in the seropositive group (mean log copy number = 5.93, range = 1.85–9.21) than the seronegative group (mean log copy number = 2.41, range = 1.85–5.43; p = 0.0026). Considering all body fluid test results, 50 (74.6%) of the 67 patients were previously infected with JCV.InterpretationThe false‐negative rate of the JCV serology in this study was 37%; therefore, JCV serostatus does not appear to identify all patients infected with JCV. Thus, a negative JCV antibody result should not be conflated with absence of JCV infection. This discordance may be important in understanding JCV biology, risk for PML, and PML pathogenesis. Ann Neurol 2013;74:84–90