bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Variable-Resolution Meshes on Midlatitude Baroclinic Eddies Using CAM-MPAS-A
Authors: Rauscher Sara A. , Ringler Todd D. 
Published: July 2014

Abstract
The effects of a variable-resolution mesh on simulated midlatitude baroclinic eddies in idealized settings are examined. Both aquaplanet and Held–Suarez experiments are performed using the Model for Prediction Across Scales-Atmosphere (MPAS-A) hydrostatic dynamical core implemented within the National Science Foundation–Department of Energy (NSF–DOE) Community Atmosphere Model (CAM-MPAS-A). In the real world, midlatitude eddy activity is organized by orography, land–sea contrasts, and sea surface temperature anomalies. In these zonally symmetric idealized settings, transients should have an equal probability of occurring at any longitude. However, the use of a variable-resolution mesh with a circular high-resolution region centered at 30°N results in a maximum in eddy kinetic energy on the eastern side and downstream of this high-resolution region in both aquaplanet and Held–Suarez CAM-MPAS-A simulations. The presence of a geographically confined maximum in both simulations suggests this response is mainly attributable to CAM-MPAS-A’s ability to resolve eddies via the model dynamics as resolution increases. However, in the aquaplanet simulation, a secondary maximum in eddy kinetic energy is present, which is probably linked to the resolution dependencies of the CAM physics. These mesh responses must be considered when interpreting real-world variable-resolution CAM-MPAS-A simulations, particularly in climate change experiments.
Auricular Reconstruction After Human Bite Amputation Using the Baudet Technique
Authors: Norman Zachary I. , Cracchiolo Jennifer R. , Allen Shannon H. , Soliman Ahmed M.S. 
Published: July 2014

Objective: This study aimed to present a case of a successful re-implantation of an amputated auricle following a human bite using the Baudet technique. Methods: Case report and review of the literature. Results: The patient had a very satisfactory postoperative result in terms of appearance and function of the reattached auricle. Cartilage loss was minimal. Conclusion: Reattachment of an amputated auricle as a composite graft following a traumatic human bite is feasible. The Baudet technique is a simple alternative that avoids the complexity of microsurgical anastomosis while improving upon the high failure rate associated with simple reattachment.
Sleep apnea in patients with cluster headache: A case-control study
Authors: Evers Stefan , Barth Birke , Frese Achim , Husstedt Ingo-W , Happe Svenja 
Published: July 2014

Objective Polysomnographic investigations have shown an unspecific association between cluster headache and obstructive sleep apnea syndrome. The aim of this study was to investigate this association in a cluster episode compared with a symptom free interval, and to further characterize this association. Methods We investigated 42 patients with episodic ( n = 26) or chronic ( n = 16) cluster headache by means of polygraphic screening for sleep apnea and compared the data to 28 healthy control subjects matched according to age, sex, and BMI. The patients with episodic cluster headache were screened twice, once in a cluster episode and once in a symptom free interval. Results Patients with active cluster headache showed a significantly higher respiratory distress index (8.6 ± 16.0) compared with healthy control subjects (3.4 ± 2.1; p = 0.002). More patients fulfilled the criteria for an obstructive sleep apnea syndrome (29%) than control subjects (7%; p = 0.018). Patients only, but not the control subjects, had central apneas. These differences were only significant when measured during an active cluster episode but not during a symptom free interval. Conclusion Cluster headache is associated with a sleep apnea syndrome only in the active cluster episode. The increased rate of central apneas might be a result of involvement of the hypothalamus in the pathophysiology of cluster headache. Out of five anecdotal cases treated with nasal continuous positive airway pressure, only one patient showed benefit with respect to cluster headache attack frequency.
Association Between Smoking and Wound Infection Rates Following Calcaneal Fracture Fixation
Authors: Soni Ashish , Vollans Samuel , Malhotra Karan , Mann Christopher 
Published: July 2014

Fixation of displaced, intra-articular calcaneal fractures has shown to improve outcome, but wound complications can be devastating for the patient. While smoking remains a factor associated with poor outcome, evidence is still somewhat contradictory. We studied the association of smoking and wound complication after calcaneal fracture fixation. In addition, we evaluated infection rates and association with age of patient, delay in surgery, tourniquet time, and Sanders classification. We conducted a retrospective cohort study in a teaching hospital from 2004 to 2011 evaluating a single surgeon series of calcaneal open reduction internal fixation via an extensile lateral approach. Patient demographics, mechanism of injury, history preexisting medical comorbidity, smoking status, soft tissue condition, delay in surgery, tourniquet time, presence of superficial or deep infection, and treatment of any infection were noted. Superficial and deep infection rate were 11.6% and 2.9%, respectively. Smokers had an increased rate of 12.5% and 6.25%, respectively. Most infections settled with antibiotics, and only 2 cases required surgical debridement. In conclusion, all the deep infections occurred in smokers whose surgery was delayed for more than 14 days. We found no increase in the rate of wound complications in association with age of patient, Sanders grading, or tourniquet time. Levels of Evidence: Prognostic Level III, retrospective comparative cohort study
Short-term glutamine supplementation decreases lung inflammation and the receptor for advanced glycation end-products expression in direct acute lung injury in mice
Authors: Chuang Yin-Ching , Shaw Huey-Mei , Chen Chi-Chung , Pan He-Jia , Lai Wei-Chih , Huang Hui-Ling 
Published: July 2014

AbstractBackgroundGlutamine (GLN) has been reported to improve clinical and experimental sepsis outcomes. However, the mechanisms underlying the actions of GLN remain unclear, and may depend upon the route of GLN administration and the model of acute lung injury (ALI) used. The aim of this study was to investigate whether short-term GLN supplementation had an ameliorative effect on the inflammation induced by direct acid and lipopolysaccharide (LPS) challenge in mice.MethodsFemale BALB/c mice were divided into two groups, a control group and a GLN group (4.17% GLN supplementation). After a 10-day feeding period, ALI was induced by intratracheal administration of hydrochloric acid (pH 1.0; 2 mL/kg of body weight [BW]) and LPS (5 mg/kg BW). Mice were sacrificed 3 h after ALI challenge. In this early phase of ALI, serum, lungs, and bronchoalveolar lavage fluid (BALF) from the mice were collected for further analysis.ResultsThe results of this study showed that ALI-challenged mice had a significant increase in myeloperoxidase activity and expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in the lung compared with unchallenged mice. Compared with the control group, GLN pretreatment in ALI-challenged mice reduced the levels of receptor for advanced glycation end-products (RAGE) and IL-1β production in BALF, with a corresponding decrease in their mRNA expression. The GLN group also had markedly lower in mRNA expression of cyclooxygenase-2 and NADPH oxidase-1.ConclusionsThese results suggest that the benefit of dietary GLN may be partly contributed to an inhibitory effect on RAGE expression and pro-inflammatory cytokines production at an early stage in direct acid and LPS-induced ALI in mice.
Concordance between decision analysis and matching systematic review of randomized controlled trials in assessment of treatment comparisons: a systematic review
Authors: Mhaskar Rahul S , Wao Hesborn , Mahony Helen , Kumar Ambuj , Djulbegovic Benjamin 
Published: July 2014

Abstract

Background
Systematic review (SR) of randomized controlled trials (RCT) is the gold standard for informing treatment choice. Decision analyses (DA) also play an important role in informing health care decisions. It is unknown how often the results of DA and matching SR of RCTs are in concordance. We assessed whether the results of DA are in concordance with SR of RCTs matched on patient population, intervention, control, and outcomes.

Methods
We searched PubMed up to 2008 for DAs comparing at least two interventions followed by matching SRs of RCTs. Data were extracted on patient population, intervention, control, and outcomes from DAs and matching SRs of RCTs. Data extraction from DAs was done by one reviewer and from SR of RCTs by two independent reviewers.

Results
We identified 28 DAs representing 37 comparisons for which we found matching SR of RCTs. Results of the DAs and SRs of RCTs were in concordance in 73% (27/37) of cases. The sensitivity analyses conducted in either DA or SR of RCTs did not impact the concordance. Use of single (4/37) versus multiple data source (33/37) in design of DA model was statistically significantly associated with concordance between DA and SR of RCTs.

Conclusions
Our findings illustrate the high concordance of current DA models compared with SR of RCTs. It is shown previously that there is 50% concordance between DA and matching single RCT. Our study showing the concordance of 73% between DA and matching SR of RCTs underlines the importance of totality of evidence (i.e. SR of RCTs) in the design of DA models and in general medical decision-making.
Inflammatory myofibroblastic tumor of the thigh without bone involvement: a case report
Authors: Lin Jun , Liu Hao , Zhuang Yin , Yang Peng , Zheng Yifei , Yang Yan , Yang Huilin 
Published: July 2014

AbstractInflammatory myofibroblastic tumors are rare, and those located in the extremities without bone involvement are even rarer. We present the case of a 61-year-old Chinese male patient with an inflammatory myofibroblastic tumor of the right thigh. It was excised and a histopathologic examination revealed an inflammatory myofibroblastic tumor. This case is presented by virtue of its rare location.
Redistribution of elements of metals in plant tissues under treatment by non-ionic colloidal solution of biogenic metal nanoparticles
Authors: Taran Nataliya , Batsmanova Ludmila , Konotop Yevheniya , Okanenko Alexander 
Published: July 2014

Abstract
The content of metal elements in plant tissues of 10-day wheat seedlings after seed pre-treatment and foliar treatment with non-ionic colloidal solution of metal nanoparticles (Fe, Mn, Cu, Zn) was determined by an atomic absorption spectrometer. It was shown that metal nanoparticles due to their physical properties (nanoscale and uncharged state) were capable of penetrating rapidly into plant cells and optimizing plant metabolic processes at the early stages of growth and development.
The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis
Authors: Engdahl Cecilia , Börjesson Anna E , Forsman Huamei F , Andersson Annica , Stubelius Alexandra , Krust Andree , Chambon Pierre , Islander Ulrika , Ohlsson Claes , Carlsten Hans , Lagerquist Marie K 
Published: July 2014

Abstract
Introduction
Estrogen (E2) delays onset and decreases severity of experimental arthritis. The aim of this study was to investigate the importance of total estrogen receptor alpha (ERα) expression and cartilage-specific ERα expression in genetically modified mice for the ameliorating effect of estrogen treatment in experimental arthritis.

Methods
Mice with total (total ERα-/-) or cartilage-specific (Col2α1-ERα-/-) inactivation of ERα and wild-type (WT) littermates were ovariectomized, treated with E2 or placebo, and induced with antigen-induced arthritis (AIA). At termination, knees were collected for histology, synovial and splenic cells were investigated by using flow cytometry, and splenic cells were subjected to a T-cell proliferation assay.

Results
E2 decreased synovitis and joint destruction in WT mice. Amelioration of arthritis was associated with decreased frequencies of inflammatory cells in synovial tissue and decreased splenic T-cell proliferation. E2 did not affect synovitis or joint destruction in total ERα-/- mice. In Col2α1-ERα-/- mice, E2 protected against joint destruction to a similar extent as in WT mice. In contrast, E2 did not significantly ameliorate synovitis in Col2α1-ERα-/- mice.

Conclusions
Treatment with E2 ameliorates both synovitis and joint destruction in ovariectomized mice with AIA via ERα. This decreased severity in arthritis is associated with decreased synovial inflammatory cell frequencies and reduced splenic T-cell proliferation. ERα expression in cartilage is not required for estrogenic amelioration of joint destruction. However, our data indicate that ERα expression in cartilage is involved in estrogenic effects on synovitis, suggesting different mechanisms for the amelioration of joint destruction and synovitis by E2.
Development of antibiotic treatment algorithms based on local ecology and respiratory surveillance cultures to restrict the use of broad-spectrum antimicrobial drugs in the treatment of hospital-acquired pneumonia in the intensive care unit: a retrospective analysis
Authors: De Bus Liesbet , Saerens Lies , Gadeyne Bram , Boelens Jerina , Claeys Geert , De Waele Jan J , Benoit Dominique D , Decruyenaere Johan , Depuydt Pieter O 
Published: July 2014

Abstract
Introduction
Timely administration of appropriate antibiotic therapy has been shown to improve outcome in hospital-acquired pneumonia (HAP). Empirical treatment guidelines tailored to local ecology have been advocated in antibiotic stewardship programs. We compared a local ecology based algorithm (LEBA) to a surveillance culture based algorithm (SCBA) in terms of appropriate coverage and spectrum of antimicrobial activity.

Methods
We retrospectively assessed 2 hypothetical empirical antibiotic treatment algorithms for HAP on an existing high-quality prospectively collected database in a mixed 36-bed tertiary intensive care unit (ICU). Data on consecutive episodes of microbiologically confirmed HAP were collected over a period of 40 months and divided in a derivation (1 July 2009 to 31 October 2010) and validation (1 November 2010 until 31 October 2012) cohort. On the derivation cohort we constructed a LEBA, based on overall observed bacterial resistance patterns, and a SCBA, which targeted therapy to surveillance culture (SC) in the individual patient. Therapy was directed against pathogens found in respiratory SC collected two to five days before HAP, and in the absence of these, presence or absence of multi-drug resistant (MDR) pathogens in other SC dictated broad-spectrum, respectively narrow spectrum antibiotic therapy. Subsequently, LEBA and SCBA were retrospectively reviewed and compared with actually prescribed antibiotics in the validation cohort.

Results
The first 100 HAP episodes made up the derivation cohort and the subsequent 113 HAP episodes the validation cohort. Appropriate antibiotic coverage rates by applying LEBA and SCBA were 88.5% and 87.6%, respectively, and did not differ significantly with respect to appropriateness of the actually prescribed initial therapy (84.1%). SCBA proposed more narrow spectrum therapy as compared to LEBA and the actually prescribed antimicrobials (P <0.001). SCBA recommended significantly less combination therapy and carbapenems compared to LEBA (P <0.001). SCBA targeted antibiotics to recent respiratory SC in 38.1% (43 out of 113 episodes) of HAP; in these cases adequacy was 93% (40 out of 43).

Conclusion
Rates of appropriate antimicrobial coverage were identical in LEBA and SCBA. However, in this setting of moderate MDR prevalence, the use of SCBA would result in a significant reduction of the use of broad-spectrum drugs and may be a preferential strategy when implementing antibiotic stewardship programs.
Enhanced luminescence intensity of novel red-emitting phosphor -Sr3Lu2(BO3)4:Bi3+,Eu3+ via energy transfer
Authors: Maggay Irish Valerie B , Lin Pin-Chun , Liu Wei-Ren 
Published: July 2014

Abstract
Bi3+/Eu3+ co-activated Sr3Lu2(BO3)4 was successfully synthesized via a solid state reaction. The optimal concentration of Bi3+,Eu3+ and Bi3+/Eu3+ are 1 mol%, 60 mol% and 1 mol%/20 mol%, respectively. The emission spectra of Sr3Lu2(BO3)4:Bi3+, Eu3+ gives three peaks located at 405 nm, 489 nm which were attributed to Bi3+ S6 (blue) and C2 (green) site symmetry, respectively and 610 nm which was ascribed to Eu3+ (5D0 → 7 F2) transition. The emission intensity of Bi3+ decreases with increasing Eu3+ content which indicates that a efficient energy transfer occurred in the Sr3Lu2(BO3)4 host. The relative intensity of Sr3Lu1.79(BO3)4:0.01Bi3+,0.20Eu3+ excited at 327 nm and 370 nm was remarkably enhanced by 201% and 265%, respectively, via the energy transfer from Bi3+ to Eu3+. The results indicate that Sr3Lu2(BO3)4:Bi3+, Eu3+ is a potential novel red-emitting phosphor for UV LED applications.
Differences in Parent-Provider Concordance Regarding Prognosis and Goals of Care Among Children With Advanced Cancer
Authors: Rosenberg Abby R. , Orellana Liliana , Kang Tammy I. , Geyer J. Russell , Feudtner Chris , Dussel Veronica , Wolfe Joanne 
Published: July 2014

Purpose Concordance between parents of children with advanced cancer and health care providers has not been described. We aimed to describe parent-provider concordance regarding prognosis and goals of care, including differences by cancer type. Patients and Methods A total of 104 pediatric patients with recurrent or refractory cancer were enrolled at three large children's hospitals. On enrollment, their parents and providers were invited to complete a survey assessing perceived prognosis and goals of care. Patients' survival status was retrospectively abstracted from medical records. Concordance was assessed via discrepancies in perceived prognosis, κ statistics, and McNemar's test. Distribution of categorical variables and survival rates across cancer type were compared with Fisher's exact and log-rank tests, respectively. Results Data were available from 77 dyads (74% of enrolled). Parent-provider agreement regarding prognosis and goals of care was poor (κ, 0.12 to 0.30). Parents were more likely to report cure was likely (P < .001). The frequency of perceived likelihood of cure and the goal of cure varied by cancer type for both parents and providers (P < .001 to .004). Relatively optimistic responses were more common among parents and providers of patients with hematologic malignancies, although there were no differences in survival. Conclusion Parent-provider concordance regarding prognosis and goals in advanced pediatric cancer is generally poor. Perceptions of prognosis and goals of care vary by cancer type. Understanding these differences may inform parent-provider communication and decision making.
BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence
Authors: Xing Mingzhao , Liu Rengyun , Liu Xiaoli , Murugan Avaniyapuram Kannan , Zhu Guangwu , Zeiger Martha A. , Pai Sara , Bishop Justin 
Published: July 2014

Purpose To investigate the prognostic value of the BRAF V600E mutation and the recently identified TERT promoter mutation chr5:1,295,228C>T (C228T), individually and in their coexistence, in papillary thyroid cancer (PTC). Patients and Methods We performed a retrospective study of the relationship of BRAF and TERT C228T mutations with clinicopathologic outcomes of PTC in 507 patients (365 women and 142 men) age 45.9 ± 14.0 years (mean ± SD) with a median follow-up of 24 months (interquartile range, 8 to 78 months). Results Coexisting BRAF V600E and TERT C228T mutations were more commonly associated with high-risk clinicopathologic characteristics of PTC than they were individually. Tumor recurrence rates were 25.8% (50 of 194;77.60 recurrences per 1,000 person-years; 95% CI, 58.81 to 102.38) versus 9.6% (30 of 313; 22.88 recurrences per 1,000 person-years; 95% CI, 16.00 to 32.72) in BRAF mutation–positive versus –negative patients (hazard ratio [HR], 3.22; 95% CI, 2.05 to 5.07) and 47.5% (29 of 61; 108.55 recurrences per 1,000 person-years; 95% CI, 75.43 to 156.20) versus 11.4% (51 of 446; 30.21 recurrences per 1,000 person-years; 95% CI, 22.96 to 39.74) in TERT mutation–positive versus –negative patients (HR, 3.46; 95% CI, 2.19 to 5.45). Recurrence rates were 68.6% (24 of 35; 211.76 recurrences per 1,000 person-years; 95% CI, 141.94 to 315.94) versus 8.7% (25 of 287; 21.60 recurrences per 1,000 person-years; 95% CI, 14.59 to 31.97) in patients harboring both mutations versus patients harboring neither mutation (HR, 8.51; 95% CI, 4.84 to 14.97), which remained significant after clinicopathologic cofactor adjustments. Disease-free patient survival curves displayed a moderate decline with BRAF V600E or TERT C228T alone but a sharp decline with two coexisting mutations. Conclusion Coexisting BRAF V600E and TERT C228T mutations form a novel genetic background that defines PTC with the worst clinicopathologic outcomes, providing unique prognostic and therapeutic implications.
Characteristic of labour potential of Primosrsky Krai
Authors: Дроздова  , Drozdova Ekaterina , Палагутина  , Palagutina N. , Мельникова  , Melnikova Marina 
Published: July 2014

Study of labor potential most actually from a line item of an assessment of implementation of potential of the person in the given working conditions as gives a certain idea of the strong and weaknesses of control of regional development as a whole.
The characteristic of labor potential is provided in this article taking into account two pacing factors of its formation and development: 1) human potential (potential of human development), 2) potential of regional social and economic subsystems. Authors gave detail statistical data across Primorsky Krai, the population characterizing a standard of living, expected life expectancy in case of the birth, a health care status, an education level — indexes which define component values of an index of the human development, published in the annual report «About human development in the Russian Federation».
The assessment of perspectives and threats of reproduction of labor capacity of Primorsky Krai has the high practical significance. Special attention is deserved by calculation of security of strategy of social and economic development of Primorsky Krai made by authors till 2025 human resources.
Support of the high level of quality of life of the population is offered As the main action for increase of use and development of labor potential of the researched region.