bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemotherapy with intravenous, intratumoral, or combined administration of bleomycin in the treatment of colorectal hepatic metastases in a rat model
Authors: Spiliotis Antonios E. , Holländer Sebastian , Wagenpfeil Gudrun , Eisele Robert , Nika Spyridon , Mallis Kyriakides Orestis , Laschke Matthias W. , Menger Michael D. , Glanemann Matthias , Gäbelein Gereon 
Published: July 2024

AbstractElectrochemotherapy (ECT) combines the reversible electroporation (rEP) with intravenous (i.v.) or intratumoral (i.t.) administration of chemotherapeutic drugs. We conducted this study to compare the efficacy of i.v., i.t., and i.v. + i.t. injection of bleomycin (BLM) in ECT treatment of colorectal hepatic metastases in a rat model. WAG/Rij rats were randomized into three groups and underwent ECT with i.v., i.t., or i.v. + i.t. injection of BLM. Tumor volumes and oxygenation were measured by means of ultrasound and photoacoustic imaging. Moreover, liver and tumor tissue were analyzed by histology and immunohistochemistry. The i.v. and i.v. + i.t. groups exhibited a 44.0% and 46.6% reduction in oxygen saturation of the tumor tissue when compared to pretreatment values, whereas the i.t. group only showed a reduction of 35.2%. The extent of tumor tissue necrosis did not statistically differ between the groups. However, the i.t. group showed a tendency towards a lower necrosis rate. Cell proliferation, apoptotic cell death, vascularization, and immune cell infiltration were comparable in the treated tumors of the three groups. ECT with i.v. administration of BLM should be preferred in clinical practice, as the combined i.v. + i.t. therapy did not show superior oncological outcomes in the present study.
Kidney outcomes are altered by preconception weight modulation in rodent mothers with obesity
Authors: Rodrigo Natassia , Chen Hui , Pollock Carol A. , Glastras Sarah J. 
Published: July 2024

AbstractObesity increases the risk of chronic kidney disease. We have previously demonstrated the benefits of preconception maternal weight loss on fertility and pregnancy outcomes in a mouse model of maternal obesity. Here, we elucidate if preconception weight loss, either by diet modification or the glucose-like peptide 1 agonist liraglutide, used in the treatment of diabetes and obesity, improves maternal kidney outcomes in late gestation. C57BL/6 female mice were fed either a high-fat-diet (HFD) or a chow (control) diet for 8 weeks. To induce pre-pregnancy weight loss, HFD-fed dams were switched to chow diet (HFD-C) or administered liraglutide (0.3 mg/kg subcutaneous) whilst continuing on HFD (HFD-L). Liraglutide was discontinued one week prior to mating. HFD-V mice continued on HFD, with saline injections. A group of HFD-fed dams were ‘diet switched’ to chow after conception (post-conception, HFD-PC). Maternal body weight and glucose tolerance were measured: (1) preconception and (2) during late gestation followed by blood, urine and kidney collection. Serum creatinine, urinary creatinine and albumin, kidney tissue gene expression and protein were measured. In the preconception period, HFD-L and HFD-C mothers have lower urine albumin:creatinine ratios (UACR) and fatty acid synthase (FAS) protein expression (P < 0.005 vs. HFD-V). At late gestation, kidneys of HFD-V and HFD-PC dams have increased gene expression of insulin receptor and FAS (P < 0.05) and higher UACR compared to controls (P < 0.01). In the HFD-PC group, kidneys show increased mRNA and protein expression of metabolic and oxidative stress markers (FAS, 8-OHdG vs. control, P < 0.05, P < 0.0001 respectively). The preconception intervention groups with liraglutide, or diet change show reduced oxidative stress (protein expression of 8-OHdG, P < 0.05 vs. HFD), mRNA and protein expression of FAS (P < 0.05 vs. HFD), protein expression of fibrosis markers (collagen IV, fibronectin vs. HFD, P < 0.05), and UACR (P < 0.05 vs. HFD). This study suggests that preconception weight loss benefits maternal kidney health during pregnancy, superior to diet intervention once already pregnant.
Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning
Authors: Yagi Masashi , Wakisaka Yushi , Takeno Jun , Kanada Shintaro , Tsubouchi Toshiro , Hamatani Noriaki , Maruo Hiroyasu , Takashina Masaaki , Ishii Takayoshi , Kanai Tatsuaki , Shimizu Shinichi , Ogawa Kazuhiko 
Published: July 2024

AbstractFew reports have documented how the accuracy of stopping power ratio (SPR) prediction for porous bone tissue affects the dose distribution of scanned carbon-ion beam therapy. The estimated SPR based on single-energy computed tomography (SECT) and dual-energy CT (DECT) were compared for the femur of a Rando phantom which simulates the porosity of human bone, NEOBONE which is the hydroxyapatite synthetic bone substitute, and soft tissue samples. Dose differences between SECT and DECT were evaluated for a scanned carbon-ion therapy treatment plan for the Rando phantom. The difference in the water equivalent length was measured to extract the SPR of the examined samples. The differences for SPR estimated from the DECT-SPR conversion were small with − 1.8% and − 3.3% for the Rando phantom femur and NEOBONE, respectively, whereas the differences for SECT-SPR were between 7.6 and 70.7%, illustrating a 1.5-mm shift of the range and a dose difference of 13.3% at maximum point in the evaluation of the dose distribution. This study demonstrated that the DECT-SPR conversion method better estimated the SPR of the porosity of bone tissues than SECT-SPR followed by the accurate range of the carbon-ion beams on carbon-ion dose calculations.
Non-invasive ventral cervical magnetoneurography as a proxy of in vivo lipopolysaccharide-induced inflammation
Authors: Bu Yifeng , Burks Jamison , Yang Kun , Prince Jacob , Borna Amir , Coe Christopher L. , Simmons Alan , Tu Xin M. , Baker Dewleen , Kimball Donald , Rao Ramesh , Shah Vishal , Huang Mingxiong , Schwindt Peter , Coleman Todd P. , Lerman Imanuel 
Published: July 2024

AbstractMaintenance of autonomic homeostasis is continuously calibrated by sensory fibers of the vagus nerve and sympathetic chain that convey compound action potentials (CAPs) to the central nervous system. Lipopolysaccharide (LPS) intravenous challenge reliably elicits a robust inflammatory response that can resemble systemic inflammation and acute endotoxemia. Here, we administered LPS intravenously in nine healthy subjects while recording ventral cervical magnetoneurography (vcMNG)-derived CAPs at the rostral Right Nodose Ganglion (RNG) and the caudal Right Carotid Artery (RCA) with optically pumped magnetometers (OPM). We observed vcMNG RNG and RCA neural firing rates that tracked changes in TNF-α levels in the systemic circulation. Further, endotype subgroups based on high and low IL-6 responders segregate RNG CAP frequency (at 30-120 min) and based on high and low IL-10 response discriminate RCA CAP frequency (at 0-30 min). These vcMNG tools may enhance understanding and management of the neuroimmune axis that can guide personalized treatment based on an individual’s distinct endophenotype.
Quasi square wave operation of modular multilevel converter based dual active bridge DC–DC converter with inductor energy recovery
Authors: Xia Peizhou , Hao Chuantong , Judge Paul , Merlin Michael , Finney Stephen 
Published: July 2024

AbstractThe modular multilevel DC–DC transformer (MMDCT) provides a reliable solution to overcome the challenges of conventional dual‐active‐bridge converters in terms of power semiconductors ratings and dv/dt stress on transformer coupling windings. An alternative modulation method, quasi‐square‐wave, was proposed to reduce the cell capacitance of modular multilevel bridges. However the application of quasi‐square‐wave modulation is found to result in underdamped switching transients and losses when resetting energy stored in arm inductance. This paper presents a detailed transient analysis of MMDCT arm insertion based on an equivalent circuit, which contributes to a more accurate component sizing and gives voltage estimation for individual half‐bridge submodules. Additionally, a revised switching sequence is proposed to recover this inductor energy and lower the oscillation‐related losses. Simulated and experimental results from a scaled test rig of MMDCT are implemented and validate the proposed component sizing and switching sequence, indicating that the converter efficiency can be improved under revised switching sequence. Finally, a silicon carbide based, high‐frequency MMDCT is proposed and simulated.
Assessment of the near-Sun magnetic field of the 10 March 2022 coronal mass ejection observed by Solar Orbiter
Authors: Koya S. , Patsourakos S. , Georgoulis M. K , Nindos A. 
Published: July 2024

Aims. We estimate the near-Sun axial magnetic field of a coronal mass ejection (CME) on 10 March 2022. Solar Orbiter’s in situ measurements, 7.8 degrees east of the Sun-Earth line at 0.43 AU, provided a unique vantage point, along with the WIND measurements at 0.99 AU. We determine a single power-law index from near-Sun to L1, including in situ measurements from both vantage points.
Methods. We tracked the temporal evolution of the instantaneous relative magnetic helicity of the source active region (AR), NOAA AR 12962. By estimating the helicity budget of the pre-and post-eruption AR, we estimated the helicity transported to the CME. Assuming a Lundquist flux-rope model and geometrical parameters obtained through the graduated cylindrical shell (GCS) CME forward modelling, we determined the CME axial magnetic field at a GCS-fitted height. Assuming a power-law variation of the axial magnetic field with heliocentric distance, we extrapolated the estimated near-Sun axial magnetic field to in situ measurements at 0.43 AU and 0.99 AU.
Results. The net helicity difference between the post-and pre-eruption AR is ( − 7.1 ± 1.2)×1041 Mx2, which is assumed to be bodily transported to the CME. The estimated CME axial magnetic field at a near-Sun heliocentric distance of 0.03 AU is 2067 ± 405 nT. From 0.03 AU to L1, a single power-law falloff, including both vantage points at 0.43 AU and 0.99 AU, gives an index −1.23 ± 0.18.
Conclusions. We observed a significant decrease in the pre-eruptive AR helicity budget. Extending previous studies on inner-heliospheric intervals from 0.3 AU to ∼1 AU, referring to estimates from 0.03 AU to measurements at ∼1 AU. Our findings indicate a less steep decline in the magnetic field strength with distance compared to previous studies, but they align with studies that include near-Sun in situ magnetic field measurements, such as from Parker Solar Probe.
Irradiation effect and binary radio pulsars with giant companions
Authors: Lan Shunyi , Meng Xiangcun 
Published: July 2024

Context. Pulsars are neutron stars that rotate rapidly. Most of the pulsars in binary systems tend to spin faster than those in isolation. According to binary evolution theory, radio pulsars in binary systems can have various types of companion stars. However, binary radio pulsars with giant stars, helium stars, and black holes as companions are lacking so far.
Aims. We aim to investigate the possible parameter space of binary radio pulsars with giant companions.
Methods. We used the MESA stellar evolution code to consider the effect of irradiation in binary evolution and evolved a series of binary models.
Results. We present the potential physical properties of binary radio pulsars with giant star companions in the framework of the classical recycling scenario and the irradiation model. We found that the parameter space of binary radio pulsars with giant companions can be greatly expanded by the effect of irradiation. Moreover, when irradiation is strong enough, submillisecond pulsars might be accompanied by giant companion stars. We also demonstrate a correlation between the timescale of the binary system as a low-mass X-ray binary and the irradiation efficiency.
Conclusions. The birthrate problem between millisecond pulsars and low-mass X-ray binaries might not be resolved by the irradiation effect. A more detailed binary population synthesis is necessary. Our findings may offer guidance for observers that wish to locate binary radio pulsars with giant companions or submillisecond pulsars.
SO2 and OCS toward high-mass protostars
Authors: Santos Julia C. , van Gelder Martijn L. , Nazari Pooneh , Ahmadi Aida , van Dishoeck Ewine F. 
Published: July 2024

Context. OCS and SO2 are both major carriers of gaseous sulfur and are the only sulfurated molecules detected in interstellar ices to date. They are thus the ideal candidates for exploring the evolution of the volatile sulfur content throughout the different stages of star formation.
Aims. We aim to investigate the chemical history of interstellar OCS and SO2 by deriving a statistically significant sample of gas-phase column densities toward massive protostars and comparing them to observations of gas and ices toward other sources, from dark clouds to comets.
Methods. We analyzed a subset of 26 line-rich massive protostars observed by ALMA in Band 6 as part of the High Mass Protocluster Formation in the Galaxy (ALMAGAL) survey. Column densities were derived for OCS and SO2 from their rare isotopologs O13CS and 34SO2 toward the compact gas around the hot cores. We compared the abundance ratios of gaseous OCS, SO2, and CH3OH with ice detections toward both high- and low-mass sources as well as dark clouds and comets.
Results. We find that gas-phase column density ratios of OCS and SO2 with respect to methanol remain fairly constant as a function of luminosity between low- and high-mass sources, despite their very different physical conditions. In our dataset, OCS and SO2 are weakly correlated. The derived gaseous OCS and SO2 abundances relative to CH3OH are overall similar to protostellar ice values, with a significantly larger scatter for SO2 than for OCS. Cometary and dark-cloud ice values agree well with protostellar gas-phase ratios for OCS, whereas higher abundances of SO2 are generally seen in comets compared to the other sources. Gaseous SO2/OCS ratios are consistent with ices toward dark clouds, protostars, and comets, albeit with some scatter.
Conclusions. The constant gas-phase column density ratios throughout low- and high-mass sources indicate an early-stage formation before intense environmental differentiation begins. Icy protostellar values are similar to the gas-phase medians and are compatible with an icy origin for these species followed by thermal sublimation. The larger spread in SO2 compared to OCS ratios with respect to CH3OH is likely due to a more water-rich chemical environment associated with the former, as opposed to a CO-rich origin for the latter. Post-sublimation gas-phase processing of SO2 can also contribute to the large spread. Comparisons to ices in dark clouds and comets point to a significant inheritance of OCS from earlier to later evolutionary stages.
Diagnostic Value of HALP Score in Detecting Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
Authors: Tel Burcin Meryem Atak , Tel Mustafa Ramiz , Bilgin Satilmis , Duman Tuba Taslamacioglu , Aktas Gulali 
Published: July 2024

Abstract
Introduction Hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been used to predict the prognosis in several types of cancers for the last few years. We aimed to reveal whether HALP score has high sensitivity and specificity in the detection of diabetic nephropathy.
Methods A cross-sectional study developed in Abant Izzet Baysal University Hospital in Bolu, Türkiye. Patients with type 2 diabetes mellitus (DM) were enrolled in the study. Study cohort included patients with diabetic nephropathy and patients without diabetic nephropathy. Pregnant women, subjects with malignancy, active infections conditions, and rheumatologic or hematologic diseases were excluded. We retrospectively analyzed and compared the HALP scores of the type 2 DM patients with and without diabetic nephropathy. Moreover, we sought correlation between HALP score and fasting glucose, glycated hemoglobin (HbA1c), and estimated glomerular filtration rate (eGFR).
Results A total of 356 DM patients, 162 with nephropathy and 194 without nephropathy were included in the study. The HALP score was 44.86 (4.5–119.9) in the nephropathic group, while it was 55.14 (13.2–173.7) in the nonnephropathic group (p < 0.001). HALP score was negatively correlated with HbA1c (r = –0.66, p = 0.003) and fasting glucose (r = –0.65, p = 0.002), while positive correlation was found between HALP score and eGFR (r = 0.13, p = 0.02). HALP score lower than 45.9% have 73% sensitivity and 52% specificity in detecting diabetic nephropathy (area under the curve: 0.64, p < 0.001, 95% confidence interval: 0.59–0.70).
Conclusion We suggest that HALP score can become a simple and easy to assess marker for diabetic nephropathy in addition to standard tests.
Capitolunate versus Four-Corner Arthrodesis for Midcarpal Arthrosis
Authors: Kurucan Etka , Kasper Alexis , Sherman Matthew , Fletcher Daniel , Beredjiklian Pedro , Tosti Rick 
Published: July 2024

Abstract
Background Midcarpal fusion is a procedure indicated for midcarpal arthrosis or instability, though the merits of fusing the triquetrohamate joint in addition to the capitolunate joint are not known. The purpose of this study was to compare capitolunate fusion with four-corner fusion with a null hypothesis that no differences would exist in outcomes.
Methods A retrospective chart review of patients with midcarpal arthrosis who underwent midcarpal fusion between the years 2013 and 2023 was conducted. Patients were separated into groups according to fusion type. Demographics and methods of fixation were recorded. Outcomes evaluated included subjective outcomes, radiographic alignment, success of fusion, range of motion, strength, and complications.
Results In total, 51 patients met inclusion criteria. Of these, 20 had capitolunate fusions and 31 had four-corner fusions. Staples were the most common form of fixation. Postoperative strength and range of motion were relatively preserved from preoperative levels in both groups. Both groups also had similar improvements in Disabilities of Arm, Shoulder, and Hand score. Capitolunate angles were not significantly different between groups; however, ulnar translocation was greater in the four-corner fusion group. Revision surgery was required in 10% of capitolunate fusions versus 29% of four-corner fusions, although this difference was not calculated to be significantly different.
Conclusion Capitolunate fusion and four-corner fusion yielded comparable improvements with respect to clinical and radiographic outcomes. Fusing the triquetrohamate joint does not appear to enhance outcomes.
Effects of Short-Term Creatine Monohydrate Supplementation Combined with Strength Training on the Physical Fitness Characteristics and Muscle Hypertrophy in Junior Women Wrestlers
Authors: Zahabi Ghadir , García-Ramos Amador , Ilic Vladimir , Nedeljkovic Aleksandar , Štajer Valdemar , Žugaj Nenad , Pekas Damir 
Published: July 2024

Abstract
Background Creatine is a nutritional supplement commonly used to increase strength performance and muscle mass, but its effects on female wrestlers are still unclear and equivocal. The purpose of the present study is to investigate the efficacy of short-term creatine monohydrate supplementation combined with strength training on the physical fitness characteristics and muscle hypertrophy in junior women wrestlers.
Methodology Eighteen women wrestlers (age = 18.7 ± 0.9 years, body mass index = 21.4 ± 2.5 kg/m2) participated in this research. Participants were randomly divided into three groups: Experimental Group 1—EXP1: (training with creatine supplementation), Experimental Group 2—EXP2: (training without creatine supplementation), and Control group (without training or creatine supplementation). Strength training was performed for 6 weeks, four sessions per week, with a training intensity ranging from 65 to 75% of the maximal heart rate reserve and one-repetition maximum. EXP1 was supplemented with 10 g creatine during training days. Various physical fitness characteristics and muscle hypertrophy variables were collected at three time points (pretest, midtest, and posttest).
Results A number of variables were significantly improved in the EXP1 after 6 weeks (weight, body mass index, one-repetition maximum, agility, muscular power, and hypertrophy) but not in the EXP2 and control groups.
Conclusion Short-term creatine supplementation, in conjunction with strength training, emerges as a highly effective approach for enhancing hypertrophy and boosting physical fitness factors in female wrestlers. Therefore, it is recommended that junior wrestlers individuals supplement with creatine during their strength training routines.
Menstrual Abnormalities and Body Adiposity among the Poumai Women of Manipur, North East India
Authors: Pao Vaveine , Meitei Sanjenbam Yaiphaba 
Published: July 2024

Abstract
Objective The present study aims to understand the prevalence of certain menstrual abnormalities among the adolescents and adults of the Poumai tribe of Manipur and explore the association of anthropometric variables and body adiposity with menstrual disorders.
Materials and Methods The study is a cross-sectional study conducted on 1,008 Poumai women among the reproductive age groups, consisting of 496 adolescents and 512 adults. Menstrual history was collected from each participant, and menstrual abnormalities in the menstrual frequency and flow volume were identified per the International Federation of Gynecology and Obstetrics classification. Relative indices of the measured anthropometric variables defined body adiposity. Descriptive statistics and tests of significance were calculated. Regression odd ratio analysis was also conducted to infer the odds ratio risk of menstrual abnormalities.
Results The overall prevalence of menstrual frequent and infrequent is 8.2% and 19.6%, respectively, where frequent is more prevalent in adolescents and infrequent in adults. Note that 15.4% and 5.6% of the women have a heavy and light flow, while comparatively, adults have a higher prevalence of heavy and light flow than adolescents. Anthropometric variables are associated with menstrual frequency abnormalities among adolescents, while these variables are associated with menstrual frequency and flow volume abnormalities in adults. Higher body adiposity has a higher odd ratio to the studied menstrual abnormalities, significantly with light menstrual flow.
Conclusion Disparity observed in the menstrual abnormalities among adolescents and adults could reflect hormonal changes. The association of obesity with menstrual abnormalities highlights the concern of weight management that can lead to healthy reproductive health in women.