bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Ether‐Based Electrolytes for Lithium‐ion Batteries
Authors: Wang Shizhu , Shi Jianyu , Liu Zhenhui , Xia Yongyao 
Published: July 2024

AbstractLithium‐ion batteries (LIBs) have emerged as vital elements of energy storage systems permeating every facet of modern living, particularly in portable electronic devices and electric vehicles. However, with the sustained economic and social development, new‐generation LIBs with high energy density, wide operating temperature range, fast charge, and high safety are eagerly expected, while conventional ethylene carbonate (EC)‐based carbonate electrolytes fail to satisfy corresponding requirements. Comparatively, ether‐based electrolyte systems with fascinating properties have recently been revived in LIBs fields, and many advanced LIBs with exciting performances under ether‐based electrolytes have been developed. This review provides an extensive overview of the latest breakthroughs concerning ether‐based electrolytes applied in LIBs with intercalation cathodes. To systematically outline the progression of ether‐based electrolytes, this review is categorized from the perspective of anodes as follows: i) graphite anode‐based LIBs; ii) silicon anode‐based LIBs; iii) lithium metal anode‐based LIBs.
The strategies pursued by urban households to cope with food insecurity: Insights from selected towns in Southern Ethiopia
Authors: Borku Abraham Woru , Utallo Abera Uncha , Tora Thomas Toma 
Published: July 2024

AbstractIntroductionFood security has become a major global concern, particularly in urban areas where households are struggling to address the issue of basic necessities mainly food that crucially dictates human health. Overcoming these challenges will require effective management mechanisms to inform policy interventions and enhance resilience at both local and global levels.ObjectivesThis study aimed to explore the coping strategies (CS) pursued by urban households in the Southern Ethiopia. Furthermore, the focus is on how households to cope with food insecurity and how using these strategies varies within households.MethodsA household survey questionnaire was conducted using a cross‐sectional design, combining both qualitative and quantitative methods to collect data. A total of 310 household heads were targeted for the required data acquisition with: The coping strategy index (CSI) to capture how people perceive and cope with food insecurity that threatens human health.ResultsThe results indicate that households used the top seven CS to address the problem of food insecurity: limiting the size of portions at mealtimes (83.9%), depending on less expensive or seasonal foods (68.1%), reducing adult consumption (66.1%), reducing the amount of food consumed (65.8%), purchasing food on credit (60.3%), renting household assets (54.8%), and migrating household members for wage labor (53.5%).ConclusionMoreover, the finding shows that the frequency of CS used by urban households in response to food insecurity is rated differently as never, rarely, sometimes, and more than 4 times per week. Therefore, targeted support programs for vulnerable groups should be implemented to ensure they receive adequate food during times of food insecurity wherein the victims' health status is imperatively to be bettered.
Antibiofilm Metabolites from Marine‐derived Streptomyces sp. ZS‐A31
Authors: Xu Yan , Pu Fanqi , Cui Yaqing , Wu Yanping , Lei Zhen , Jiang Yongjun 
Published: July 2024

AbstractA novel compound streptothiomycin F (1), and a new natural product, N‐(5‐nitropentyl)acetamide (2), were discovered alongside ten previously identified compounds (3‐12) through solid fermentation of marine‐derived Streptomyces sp. ZS−A31 based on rice. The chemical structures of compounds 1–2 were elucidated using 1D and 2D NMR, as well as HRESIMS data analysis. Evaluation of all isolated compounds for their antibiofilm and antibacterial activities against P. aeruginosa was carried out using microdilution and crystal violet staining methods. Results highlighted the weak potency of the known compounds lumichrome (3) and vanillic acid (7) in inhibiting biofilm formation.
CO2‐Mediated Oxidative Dehydrogenation of Propane over Zn Modified SSZ‐39 Catalysts
Authors: Zhou Shiqi , Zhang Hengwei , Jiang Xiao , Liu Chunyan , Chen Shaoyun , Liu Jiaxu 
Published: July 2024

AbstractTo reveal the catalytic function of Brønsted acid sites (BAS) and different Zn Lewis acid sites (LAS) over SSZ‐39 and Zn modified SSZ‐39 in the direct dehydrogenation of propane (DHP) and CO2‐mediated oxidative dehydrogenation (CO2‐ODHP) to propylene, a series of Zn‐modified H(Na)SSZ‐39 catalysts with various Zn loadings was prepared and conducted comparative studies between DHP and CO2‐ODHP. Detailed characterization results reveal the Zn‐loading‐dependent formation of Zn sites, primarily including Zn2+ and [Zn−O−Zn]2+, as well as their contributions in generating Lewis acid sites while neutralizing Brønsted acid sites of HSSZ‐39, namely bridged Si(OH)Al groups. In DHP, in comparison to bare HSSZ‐39, Zn/HSSZ‐39 catalysts exhibited a significantly enhanced C3H8 conversion. The presence of CO2 even further promoted C3H8 conversion in comparison to DHP. Given the above observations, we prepared Zn/NaSSZ‐39, in which the incorporation of Na further enriches the Lewis acid sites while neutralizing Brønsted acid sites of zeolite. Zn/NaSSZ‐39 even outperforms Zn/HSSZ‐39 catalysts with almost doubled C3H6 yield for CO2‐ODHP. The BAS has a poor CO2‐ODHP performance but can enhance the CO2 conversion towards CO significantly, while the Zn LAS is favorable for the CO2‐ODHP reaction, and plausible reaction paths of CO2‐ODHP on active sites are proposed.
Evaluating artificial intelligence–enhanced digital urine cytology for bladder cancer diagnosis
Authors: Liu Tien‐Jen , Yang Wen‐Chi , Huang Shin‐Min , Yang Wei‐Lei , Wu Hsing‐Ju , Ho Hui Wen , Hsu Shih‐Wen , Yeh Cheng‐Hung , Lin Ming‐Yu , Hwang Yi‐Ting , Chu Pei‐Yi 
Published: July 2024

AbstractBackgroundThis study evaluated the diagnostic effectiveness of the AIxURO platform, an artificial intelligence–based tool, to support urine cytology for bladder cancer management, which typically requires experienced cytopathologists and substantial diagnosis time.MethodsOne cytopathologist and two cytotechnologists reviewed 116 urine cytology slides and corresponding whole‐slide images (WSIs) from urology patients. They used three diagnostic modalities: microscopy, WSI review, and AIxURO, per The Paris System for Reporting Urinary Cytology (TPS) criteria. Performance metrics, including TPS‐guided and binary diagnosis, inter‐ and intraobserver agreement, and screening time, were compared across all methods and reviewers.ResultsAIxURO improved diagnostic accuracy by increasing sensitivity (from 25.0%–30.6% to 63.9%), positive predictive value (PPV; from 21.6%–24.3% to 31.1%), and negative predictive value (NPV; from 91.3%–91.6% to 95.3%) for atypical urothelial cell (AUC) cases. For suspicious for high‐grade urothelial carcinoma (SHGUC) cases, it improved sensitivity (from 15.2%–27.3% to 33.3%), PPV (from 31.3%–47.4% to 61.1%), and NPV (from 91.6%–92.7% to 93.3%). Binary diagnoses exhibited an improvement in sensitivity (from 77.8%–82.2% to 90.0%) and NPV (from 91.7%–93.4% to 95.8%). Interobserver agreement across all methods showed moderate consistency (κ = 0.57–0.61), with the cytopathologist demonstrating higher intraobserver agreement than the two cytotechnologists across the methods (κ = 0.75–0.88). AIxURO significantly reduced screening time by 52.3%–83.2% from microscopy and 43.6%–86.7% from WSI review across all reviewers. Screening‐positive (AUC+) cases required more time than negative cases across all methods and reviewers.ConclusionsAIxURO demonstrates the potential to improve both sensitivity and efficiency in bladder cancer diagnostics via urine cytology. Its integration into the cytopathological screening workflow could markedly decrease screening times, which would improve overall diagnostic processes.
Study on the role of MYCN in retinoblastoma by inhibiting p53 and activating wnt/βcatenin/Fra‐1 signaling pathway by reducing DKK3
Authors: Chen Xinke , Ouyang Lijuan , Ke Ning , Pi Lianhong , Zhou Xiyuan 
Published: July 2024

AbstractRetinoblastoma (RB) is a pediatric malignancy, typically diagnosed at birth or during early childhood. The pathogenesis of RB is marked by the amplification of the Basic Helix–Loop–Helix (BHLH) Transcription Factor MYCN, which serves as a transcriptional regulator capable of binding to Dickkopf 3 (DKK3). However, the precise role of DKK3 in the malignant progression of RB cells caused by MYCN remains elusive. In the present study, the expression of MYCN was either overexpressed or interfered in RB cells. Subsequently, the expression level of DKK3 was assessed through quantitative real‐time polymerase chain reaction and western blot analysis. Cell proliferation was evaluated using the Cell Counting Kit‐8 assay and 5‐ethynyl‐2′‐deoxyuridine staining, while cell cycle progression and apoptosis were analyzed by flow cytometry and western blot analysis, respectively. Additionally, the expression of proteins involved in the Wnt/β‐catenin/Fra‐1/p53 signaling pathway was evaluated via western blot analysis. To gain further insights, Wnt agonists and the P53 inhibitor PFT‐α were introduced into exploration. The current investigation revealed a negative correlation between the expression levels of MYCN and DKK3 in RB cells. Additionally, DKK3 overexpression inhibited cell proliferation, promoted cell apoptosis, and arrested cell cycle in RB cells with high expression of MYCN. Moreover, enhanced DKK3 expression inhibited proliferation, promoted cell cycle arrest and apoptosis of RB cells by modulating the wnt/βcatenin/Fra‐1/p53 signaling pathway. Furthermore, in vivo experiments revealed that overexpression of DKK3 inhibits the growth of RB tumors. Collectively, our findings elucidate that MYCN stimulates the Wnt/β‐catenin/Fra‐1 pathway by suppressing DKK3 expression, ultimately suppressing p53 activity and contributing to malignant progression of RB.
Detection differences between eDNA and mid‐water trawls are driven by fish biomass and habitat preferences
Authors: Rehill Tessa , Millard‐Martin Ben , Lemay Matt , Sheridan Kate , Mueller Anya , Morien Evan , Clemente‐Carvalho Rute B. G. , Hunt Brian P. V. , Sunday Jennifer M. 
Published: July 2024

AbstractMarine scientific trawl surveys are commonly used to assess the distribution and population size of fisheries‐related species, yet the method is effort‐intensive and can be environmentally destructive. Sequencing environmental DNA (eDNA) from water samples can reveal the presence of organisms in a community without capturing them; however, we expect the detectability of taxa to differ between eDNA and trawl surveys, and understanding how species traits and population variables contribute to detection differences can help calibrate our expectations from each form of sampling. Here, we coupled eDNA metabarcoding and capture trawl surveys in British Columbia, Canada, to examine species traits that explain recurrent differences in detectability between the two methods, including habitat, body size, and biomass. At the regional scale, 17 of 23 fish species (74%) captured by the trawl were detected by eDNA metabarcoding, and 39 additional species were detected by eDNA sampling only. We found that eDNA metabarcoding disproportionately detected trawl‐caught species with greater local biomass (i.e., greater biomass in the adjacent trawl). Fish detected only in eDNA had a greater range of body lengths and a broader range of habitat preferences outside the trawls' target size and sampling areas. Our results suggest that with our level of sampling, eDNA metabarcoding can adequately recapitulate detection of fish communities detected by trawl surveys, but with a bias toward fish of high population biomass and greater inclusion of fish from outside the trawled area.
Comparative evaluation of craving, sleep quality, sexual function and quality of life in opioid use disorder patients in remission with buprenorphine/naloxone maintenance treatment
Authors: Türker Zübeyde Güllü , Erdoğan Ali , Cinemre Buket , Metin Özmen , Kulaksızoğlu Burak 
Published: July 2024

AbstractAimTo compare opioid use disorder (OUD) patients who continue to use opioids and are in remission with buprenorphine‐naloxone (B/N) in terms of some parameters and to evaluate the relationship between B/N dose and these parameters.MethodWe included 141 OUD patients in remission with B/N maintenance treatment for at least 6 months, 141 who still used opioids, and 141 healthy volunteers. Substance Craving Scale (SCS), Pittsburgh Sleep Quality Index (PSQI), Arizona Sexual Experiences Scale (ASEX), and Short Form 36 (SF‐36) were administered.ResultsPSQI scores and ASEX scores were higher in those who continued to use opiates than in OUD in remission, and in OUD in remission compared to controls. OUD patients with current opioid use also had lower SF‐36 scores compared to both patients in remission and healthy controls. SCS, PSQI, ASEX, and SF‐36 scores were similar when the three groups were examined based on the dosage of B/N (below 8, 8–15, and 16 mg/day and above) use in OUD in remission.ConclusionsQuality of life, craving, sleep and sexual functions improved significantly with B/N; however, these effects are not dependent on B/N dosage.
Cervical cancer incidence in Denmark: Disentangling determinants of time trend
Authors: Lynge Elsebeth , Bennekou Schroll Jeppe , Andersen Berit , Balasubramaniam Kirubakaran , Poulsgaard Frandsen Anna , Ibfelt Else Helene , Jochumsen Kirsten Marie , Bruun Laustsen Maja Ulrikka , Nielsen Susanne , Salmani Rouzbeh , Schledermann Doris , Hall Viborg Petra Birgitta , Waldstrøm Marianne , Napolitano George , Serizawa Reza 
Published: July 2024

AbstractCervical cancer is a preventable disease. Nevertheless, stagnation has been seen in incidence rates also in countries with well‐functioning healthcare. On this basis, we investigated associations between control interventions and changes in cervical cancer incidence in Denmark from 2009 to 2022. Data on human papillomavirus (HPV)‐vaccination were retrieved from Staten's Serum Institute; on screening recommendations from Danish Health Authority, on screening performance from Danish Quality Database for Cervical Screening; and on cervical cancer incidence from Nordcan and Danish Cancer Register. We reported coverage with HPV vaccination (1+ dose); coverage with cervical cell samples; number of women with primary HPV tests; proportion of non‐normal cell samples without timely follow‐up; number of conizations; and cervical cancer incidence rates. In 2022, all women aged ≤29 had been offered childhood HPV vaccination with coverage of 80%–90%. By 2020–2022, the cervical cancer incidence rate in women aged 20–29 was 3 per 100,000; at level of disease elimination. In 2017, women aged 70+ were offered a one‐time HPV screening, and by 2020–2022, the old‐age peak in cervical cancer incidence had largely disappeared. From 2009 to 2022, proportion of non‐normal cell samples without timely follow‐up decreased from 20% to 10%, and conventional cytology was largely replaced by SurePath liquid‐based cytology; these factors could explain the steady decrease in cervical cancer incidence rate. Implementation of primary HPV screening in women aged 30–59 in 2021 was reflected in a, probably temporary, increase in the 2022 cervical cancer incidence rate. In conclusion, combined interventions with childhood HPV vaccination; one‐time HPV screening of elderly women; and better management of screening broke previous stagnation in cervical cancer incidence rate.
Medical marijuana legalization and parenting behaviors: An analysis of the time use of parents
Authors: Bansak Cynthia , Kim Jun Hyung 
Published: July 2024

SummaryCan access to medical marijuana improve parenting? We examine the consequences of state‐level medical marijuana legalization (MML) on parents' time use. Medical marijuana may increase parenting time by improving parents' health but only if parents do not abuse marijuana. We find that MML increases parenting time, with bigger impacts for those less likely to abuse marijuana. The effects correspond to 12.56% of the gap in active childcare and 8.92% of the gap in passive childcare by parents' education level. MML also reduces inactive time and increases sleep, consistent with medical marijuana's health benefits.
MicroRNA‐505‐3p mediates cell motility of epithelial ovarian cancer via suppressing PEAK1 expression
Authors: Wu Yanni , Xue Lei , Xiong Wei , Li Haiyang , Wu Jiao , Xie Wei , Long Ying , Liu Ying , Luo Chenhui 
Published: July 2024

AbstractMicroRNAs (miRNAs) are a class of small RNA genes with important roles in cancer biology regulation. There are considerable studies regarding the roles of microRNA‐505‐3p (miR‐505‐3p) in cancer development and progression, but the function of miR‐505‐3p in epithelial ovarian cancer (EOC) has not been fully clarified. Comparative analysis of miRNA expression data set was used to select differentially expressed miRNAs. Quantitative real‐time polymerase chain reaction was applied to detect expression levels of RNAs, while western blot and immunofluorescence staining were performed to detect expression levels of proteins of interest. The motility of EOC cells was assessed by wound healing and transwell assays. The binding and regulating relationship between miRNA and its direct target gene was investigated by dual‐luciferase assay. Our results show that miR‐505‐3p was upregulated in recurrent EOC, which significantly inhibits EOC cell motility via modulating cell epithelial–mesenchymal transition. Furthermore, our results indicated that PEAK1 expression was inhibited by direct binding of miR‐505‐3p into its 3′‐URT in EOC cells. Importantly, knockdown of PEAK1 attenuated the effect of mi‐505‐3p inhibitor on EOC cell migration and invasion. In conclusion, our findings indicate that miRNA‐505‐3p inhibits EOC cell motility by targeting PEAK1.
Fracture resistance of ultratranslucent multilayered zirconia veneers with different facial thicknesses
Authors: Jurado Carlos A. , Tsujimoto Akimasa , Rojas‐Rueda Silvia , Mekled Salwa , Alaqeely Razan , Alsayed Hussain D. , Alhotan Abdulaziz 
Published: July 2024

AbstractTo assess the fracture resistance of computer‐aided design and computer‐aided manufacturing (CAD/CAM) ultratranslucent multilayered zirconia (5Y‐YZP) veneers with varying facial thickness. Sixty translucent zirconia veneers were designed and milled using a chairside CAD/CAM system for maxillary central incisors. The butt joint incisal veneer tooth preparations consisted of 1.00 mm incisal reduction, 0.40 mm chamfer margin, and three different facial reductions; 0.50, 0.75, and 1 mm, respectively. The ceramic veneers were cemented to printed resin dies and subjected to thermal cycling. Subsequently, the restorations were loaded with compressive loading force, and fracture occurrences were recorded. Scanning electron microscope (SEM) images of the fractured specimens were captured. The fracture resistance varied among the veneers with different facial thicknesses. Ultratranslucent zirconia veneers with a facial thickness of 1.00 mm exhibited the highest fracture resistance values (742.15 N), followed by those with 0.75 mm facial thickness (673 N). Minimally invasive veneers with 0.50 mm thickness displayed similar fracture resistance as thicker veneers with 0.75 mm. However, veneers with 1.00 mm thickness displayed the highest values. SEM fracture patterns for 0.50 and 0.75 mm display similar and fewer crack lines than 1.00 mm veneers.Research Highlights
Minimally invasive zirconia veneers exhibit similar fracture resistance to thicker veneers.
Peri‐implantitis induction and resolution around zirconia versus titanium implants
Authors: Esplin Kaleb C. , Tsai Yi‐Wen , Vela Kathryn , Diogenes Anibal , Hachem Lea El , Palaiologou Archontia , Cochran David L. , Kotsakis Georgios A. 
Published: July 2024

AbstractBackgroundThis study compared titanium and zirconia implant ligature‐induced peri‐implant defect progression and response to regenerative surgical intervention.MethodsEight tissue‐level endosseous implants were placed in 6 mixed‐breed foxhounds, with 2 zirconia and 2 titanium alternating in each hemimandible. Cotton ligatures were placed subgingivally for 16 weeks followed by 8 weeks of spontaneous progression. Standardized radiographs were captured every 2 weeks to evaluate the rate of bone loss. Regenerative surgery was performed utilizing water‐jet decontamination, enamel matrix derivative, and locally harvested autogenous bone. After 16 weeks of healing, final radiographic bone levels as well as probing depths, recession, and clinical attachment levels were assessed.ResultsAll 48 implants integrated successfully. The final average post‐ligature radiographic defects were 2.88 and 3.05 mm for titanium and zirconia implants, respectively. There was no significant difference between materials in the rate of radiographic bone loss (p = 0.09). Following regenerative surgery, the total average amount of radiographic bone gain was 1.41 and 1.20 mm for titanium and zirconia, respectively. The percentage of defect fill was 51.56% and 37.98% (p = 0.03) for titanium and zirconia, respectively. Inter‐group differences were minimal for clinical parameters at the time of sacrifice including periodontal pocket depths (p = 0.81), recession (p = 0.98), or clinical attachment levels (p = 0.51).ConclusionsNo significant difference was found in the rate of peri‐implant defect development between titanium and zirconia implants. Both materials gained significant radiographic bone following regenerative surgery with significantly greater defect percentage fill in titanium implants. The final clinical parameters were similar in both groups.
Convergence analysis of state estimation for UAV formation under GPS‐denied environments
Authors: Ding Yu , Wang Zhengye , Cong Yirui , Wang Xiangke 
Published: July 2024

AbstractIn this article, we focus on the state estimation and formation control problem for a multi‐UAV system, where only parts of UAVs have GPS measurements, that is, the anchors, and the other UAVs measure their relative positions with anchors. With a second‐order discrete‐time model of each UAV in the formation, we analyze the convergence of state estimation (including its expectation and covariance) for commonly used consensus‐based formation control protocols, under the effect of control and measurement noise. More specifically, based on the discrete‐time stability analysis, we obtain the sufficient and necessary conditions for the expectation stability of the formation control. Using the fixed point theorem in positive symmetric matrix subspace and observability analysis, we rigorously prove that the covariance of estimation is bounded if and only if the anchor node set is globally reachable. Based on our analysis, the formation control parameters and system topology can be designed to satisfy sufficient conditions, such that the desired formation pattern can be achieved for the multi‐UAV dynamic system under GPS‐denied environments. Simulation results corroborate the effectiveness of our theoretical results.