bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychische Belastung des intensivmedizinischen Personals in Deutschland im Verlauf der COVID-19-Pandemie. Evidenz aus der VOICE-Studie
Authors: Niecke Alexander , Henning Michaela , Hellmich Martin , Erim Yesim , Morawa Eva , Beschoner Petra , Jerg-Bretzke Lucia , Geiser Franziska , Baranowski Andreas M. , Weidner Kerstin , Mogwitz Sabine , Albus Christian 
Published: August 2024

Zusammenfassung

Hintergrund
Die Coronavirus(COVID-19)-Pandemie hat das Gesundheitswesen weltweit vor große Herausforderungen gestellt und zu besonderen Belastungen des medizinisch tätigen Personals geführt. Das Ziel dieser Analyse war es zu untersuchen, wie hoch in Deutschland die globale psychische Belastung von in der direkten Krankenversorgung tätigem Personal im Verlauf der COVID-19-Pandemie war.

Methoden
In dieser prospektiven Querschnittstudie mit vier Messzeitpunkten (T1: 4–5/2020, T2: 11/2020–1/2021, T3: 5–7/2021, T4: 2–5/2022) wurden psychische Belastungssymptome im Rahmen eines Online-Surveys mit dem Patient Health Questionnaire (PHQ-4) bei Krankenhauspersonal, das in der direkten Patientenversorgung tätig war, erfasst (N = 5408 Datensätze). Der Gesamtdatensatz wurde explorativ nach Tätigkeitsbereich, Geschlecht und Berufsgruppenzugehörigkeit analysiert sowie der Verlauf über die vier Messzeitpunkte hinweg betrachtet.

Ergebnisse
Eine klinisch relevante psychische Belastung (PHQ-4 ≥ 5) lag bei 29,3 % (n = 419/1429) des intensivmedizinischen Personals vor. Im Vergleich der vier Querschnittserhebungen zeigte sich eine signifikante Steigerung der Rate klinisch relevanter psychischer Belastung im ersten Pandemiejahr (23,2 % zu T1 vs. 30,6 % zu T2; p < 0,01), welche sich im zweiten Pandemiejahr auf hohem Niveau stabilisierte (33,6 % zu T3 bzw. 32,0 % zu T4). Frauen unterschieden sich dabei nicht von den Männern (n = 280/919 vs. n = 139/508 bzw. 30,4 % vs. 27,4 %; p = 0,74). Pflegekräfte waren signifikant häufiger psychisch belastet als ärztliches Personal (n = 339/1105 vs. n = 80/324 bzw. 30,7 % vs. 24,7 %; p = 0,03). Das Intensivpersonal wies keine signifikant höhere Belastung auf als das in nichtintensivmedizinischen Funktionsbereichen tätige Personal (n = 419/1429 vs. n = 1149/3979 bzw. 29,3 % vs. 28,7 %, p = 0,21).

Schlussfolgerung
Mitarbeitende im deutschen Gesundheitswesen gaben in der Pandemie eine hohe und im Verlauf ansteigende psychische Belastung an, jedoch fand sich in unserer Stichprobe kein signifikanter Unterschied zwischen intensivmedizinischem und nichtintensivmedizinischem Personal. Dies ist möglicherweise dadurch bedingt, dass die Pandemie in Deutschland international vergleichsweise moderat verlief und weder ein Kollaps des Gesundheitssystems im Allgemeinen noch eine Dekompensation des intensivmedizinischen Versorgungssektors im Besonderen stattfand.
Transobturator-cable-fixation in pelvic ring injuries with symphyseal disruption – a last resort?
Authors: Jordan Martin C. , Wagner Richard , Hufnagel Lukas , Bremer Justus , Heilig Maximilian , Heilig Philipp , Bretherton Christopher P. , Meffert Rainer H. 
Published: August 2024

Abstract
Purpose
The role of transobturator-cable-fixation (TOCF) in traumatic symphyseal rupture of the pelvic ring remains unclear. This case series aims to evaluate TOCF in complex and revision cases in pelvic surgery.

Methods
A retrospective analysis of a chronological case series was conducted, studying pelvic fractures stabilized using TOCF between January 2006 and December 2022. The variables considered included age, gender, fracture classification, Injury Severity Score (ISS), Body Mass Index (BMI), trauma mechanism, time to surgery, fixation technique, hospital duration, complications, status on discharge (Glasgow Outcome Scale; GOS), follow-up time and indication for the use of TOCF.

Results
All patients (N = 7) were male with a mean age of 64 years and a mean BMI of 29. The mean ISS was 45, with the lowest ISS of 25, indicating that only polytraumatized patients were included. Two anterior-posterior-compression-, four lateral-compression-, and one vertical-shear-pelvic-injury were identified. TOCF was added in six cases to support symphyseal plating and in one case to external fixation. The mean hospital stay was 49 days and the mean follow-up duration was 8.5 months. No complications associated with TOCF were observed during the surgical procedure or follow-up.

Conclusion
TOCF showed no procedure-associated complications and effectively supported symphyseal healing in all cases. The main indications were obesity, poor bone quality in elderly patients, and revision cases. TOCF could be considered as a last treatment option in open-book pelvic injuries where plating or external fixation is at risk to fail.
The Knee injury and Osteoarthritis Outcome Score (KOOS) for lateral tibial plateau fractures– relevance, reliability and responsiveness
Authors: Traerup Jens , Larsen Peter , Elsøe Rasmus 
Published: August 2024

Abstract
Background
This study aimed to evaluate the patient-reported relevance, test-retest reliability, and responsiveness for each of the five KOOS subscales in patients with lateral tibial plateau fractures.

Methods
Adult patients with surgically treated lateral tibial plateau fractures (AO 41B) were included. The primary outcome measure was the KOOS subscales: Pain, Symptoms, Activity of Daily Living (ADL), Sport and Recreational Activities (Sport/rec), and kne-related Quality of Life (QOL). The KOOS was repeated at 14 and 15 days, six weeks, and 6 and 12 months. Content validity was partly evaluated by patients ranking the relevance of all the items in the KOOS, test-retest reliability by an interclass correlation coefficient, and responsiveness by effect size and based on 3 pre-defined hypotheses related the the global rating of change.

Results
Forty-one patients with a mean age of 54.8 years (ranging from 21 to 81 years) were included. The results showed an acceptable relevance of all the KOOS subscales. The test-retest reliability was moderate to high for all five subscales, with an interclass-correlation coefficient ranging from 0.6 to 0.9. At the 6- and 12-month follow-ups, the responsiveness showed large effect sizes for all the KOOS subscales, ranging from 0.9 to 2.1. Moderate to high correlations (r ≥ 0.4)was observed for the predefine hypotheses.

Conclusion
The KOOS questionnaire showed acceptable relevance, high test-retest reliability and acceptable responsivness within one year following a lateral tibial plateau fracture. More research is needed for further validation of psychometric properties of KOOS for patients with lateral tibial plateau fractures.
Analysis of spine motion during prehospital extrication procedures in motorsport
Authors: Uzun Davut Deniz , Klein Roman , Rittmann Adrian , Häske David , Schneider Niko R. E. , Kreinest Michael 
Published: August 2024

Abstract
Purpose
The appropriate extrication techniques for trauma patients after car accidents remain a topic of controversy. Various techniques for immobilizing the cervical spine during prehospital extrication have been investigated.

Methods
This explorative study compared the amount of spinal motion during five different extrication procedures from a racecar and a rallycar performed by two teams: a professional motorsport extrication team and a team of professional emergency medical technicians (EMTs). Two different microelectromechanical systems were used to measure spinal motion, and a motionscore was calculated to compare the amount of remaining spinal motion. A high motionscore indicates high remaining motion and a low motionscore indicates low remaining motion.

Results
The use of an extricable seat results in a mean overall motion score of 1617 [95% CI 308–2926]. Emergency extrication without equipment resulted in the lowest overall motionscore 1448 [95% CI 1070–1826]. In case of urgent extrication the Extrication team attained a motionscore of 2118 [95% CI 517–3718] and the EMT team a motionscore of 2932 [95% CI 1427–4435]. When performing the procedure with the aid of a rescue boa, the EMT team achieved an overall mean motionscore in the same range 2725 [95% CI 568–4881] with boa vs. 2932 [95% CI 1427–4435] without boa. When mean scores of individual spinal segments were analyzed, we found that the EMT team did especially worse in immobilizing the cervical spine 198 vs. 758.

Conclusions
Regular training of extrication procedures has paid off considerably in reducing spinal movement during extrication from a racecar. If an extricable seat is available, extrication should be performed using it. However, if emergency extrication is necessary, an additional manual cervical spine immobilization should be conducted using the Rautek maneuver to sufficiently reduce cervical spine movement.
Hemoglobin level, degree of mobilization, and pneumonia are associated with the development of postoperative delirium in cemented hemiarthroplasty after femoral neck fracture
Authors: Riemenschneider Julia , Dobrawa Pascal , Sturm Ramona , Meier Simon L. , Verboket René , Marzi Ingo , Störmann Philipp 
Published: August 2024

Abstract
Purpose
The aim of this retrospective study was to identify independent prognostic factors for developing a postoperative delirium (POD) in patients suffering from a proximal femoral neck fracture and treated by implantation of a hemiprosthesis.

Methods
A retrospective study, including patients with hip hemiarthroplasty due to a femoral neck fracture between 2011 and 2020 was performed. Demographic data, preexisting conditions, intra-/postoperative complications, mobilization and laboratory results were extracted from the patients’ charts. The different parameters were analyzed comparing patients with and without POD.

Results
412 patients, mean age of 81 ± 9.58 years were included, 66.5% (n = 274) were female, 18.2% (n = 75) of them developed a POD. Significantly higher incidence of POD was associated with older age (p < 0.001), lower level of haemoglobin (p < 0.001), higher post-surgery interleukin 6 (IL 6) level (p = 0.008), higher postoperative level of leukocytes (p = 0.01). Patients with POD received more units of packed red blood cells (PRBC) (p = 0.007). Patients with no mobility limitations pre-operatively developed POD less frequently (p = 0.01), whereas suffering from pneumonia (p = 0.03) or limited mobility postoperatively increased the risk of POD (p < 0.001).

Conclusion
This study could help to identify patients with a risk for developing POD after a hemiarthroplasty in femoral neck fractures. As a consequence, frequent controls of Hb, IL 6 and leucocytes levels to avoid anemia and infections, as well as the well surgical treatment to guarantee a good postoperative outcome.
Microstructures and mechanical properties of friction stir welded additively manufactured Scalmalloy®
Authors: Mirandola Pietro , Novel David , Perini Matteo , Benedetti Matteo , Lombardi Franco , Lunetto Vincenzo , Spena Pasquale Russo 
Published: August 2024

AbstractThe development of high-strength advanced additively manufactured (AM) aluminum alloys is driven by the need for weight reduction in complex-shaped structural applications. In this context, heat-treatable aluminum-scandium alloy, known commercially as Scalmalloy®, offers high strength and lightness, also at high temperatures, due to solution strengthening Al3(Sc, Zr) particles. A widespread diffusion of such AM alloy is also related to welding technologies that could preserve its engineered microstructure. This study investigates the microstructural and mechanical properties of butt friction stir welding (FSW) joints of LPBF Scalmalloy® plates under different welding settings. Joint performance was evaluated under quasi-static and cyclic loading conditions. Porosity in Scalmalloy® and welds was assessed using 3D X-ray computed tomography. An aging heat treatment assessed the extent of precipitation hardening in the FSW joints. Results show that metal stirring during FSW notably reduced the intrinsic porosity of Scalmalloy®, decreasing the equivalent pore diameter from about 200 μm to 60 μm in the welded joints. Under quasi-static loading, welded specimens failed at the interface between the thermo-mechanically affected and the stir zones on the advancing side. The aging heat treatment improved the mechanical strength of Scalmalloy® from approximately 400 to 480 MPa, albeit at the expense of ductility (elongation at fracture decreased from 16 to 4%). The higher heat input and stirring developed at a low welding speed reduced lazy S defects but limited the effectiveness of subsequent aging. In fatigue testing, welded joints consistently failed within the aged base material due to the intrinsic porosity of Scalmalloy®.
Impact of additives on syntrophic propionate and acetate enrichments under high-ammonia conditions
Authors: Pinela Eduardo , Schnürer Anna , Neubeck Anna , Moestedt Jan , Westerholm Maria 
Published: August 2024

Abstract
High ammonia concentrations in anaerobic degradation systems cause volatile fatty acid accumulation and reduced methane yield, which often derive from restricted activity of syntrophic acid-oxidising bacteria and hydrogenotrophic methanogens. Inclusion of additives that facilitate the electron transfer or increase cell proximity of syntrophic species by flocculation can be a suitable strategy to counteract these problems, but its actual impact on syntrophic interactions has yet to be determined. In this study, microbial cultivation and molecular and microscopic analysis were performed to evaluate the impact of conductive (graphene, iron oxide) and non-conductive (zeolite) additives on the degradation rate of acetate and propionate to methane by highly enriched ammonia-tolerant syntrophic cultures derived from a biogas process. All additives had a low impact on the lag phase but resulted in a higher rate of acetate (except graphene) and propionate degradation. The syntrophic bacteria ‘Candidatus Syntrophopropionicum ammoniitolerans’, Syntrophaceticus schinkii and a novel hydrogenotrophic methanogen were found in higher relative abundance and higher gene copy numbers in flocculating communities than in planktonic communities in the cultures, indicating benefits to syntrophs of living in close proximity to their cooperating partner. Microscopy and element analysis showed precipitation of phosphates and biofilm formation in all batches except on the graphene batches, possibly enhancing the rate of acetate and propionate degradation. Overall, the concordance of responses observed in both acetate- and propionate-fed cultures highlight the suitability of the addition of iron oxide or zeolites to enhance acid conversion to methane in high-ammonia biogas processes.

Key points
• All additives promoted acetate (except graphene) and propionate degradation.
• A preference for floc formation by ammonia-tolerant syntrophs was revealed.
• Microbes colonised the surfaces of iron oxide and zeolite, but not graphene.

Graphical Abstract
Scandinavium lactucae sp. nov. Isolated from Healthy Lettuce in South Korea
Authors: Park Jiwon , Park Sieun , Oh Kwang-Kyo , Franz Charles M. A. P. , Cho Gyu-Sung 
Published: August 2024

AbstractFour Gram-negative, facultative anaerobic, oxidase-negative and catalase-positive strains were isolated from lettuce sample collected from test beds at the National Institute of Agricultural Sciences in Wanju, South Korea. The whole genome sequences of the strains ranged from 4,624,629 to 4,849,846 bp in size, with DNA G + C contents of 54.32 to 54.56 mol%. Phylogenetic analyses based on 16S rRNA gene and four housekeeping (atpD, gyrB, infB, and rpoB) gene sequences showed that the four strains clustered closely together with Scandinavium type strains within the Enterobacteriaceae family. Moreover, the average nucleotide identity and digital DNA-DNA hybridization value of the proposed type strain (V105_6T) with the closely related Scandinavium type strains were in the range of 85.71–86.16% and 30.2–31.2%, respectively, which were all below the species delineation threshold values. The major cellular fatty acid of V105_6T was C16:0. Growth was observed at 7, 10 and 35 °C, and in the presence of 7% NaCl concentration. Based on phenotypic and genotypic results, strain V105_6T represents a novel species of the genus Scandinavium, for which the name Scandinavium lactucae sp. nov. is proposed. The type strain is V105_6T (= LMG 33389T = DSM 117134T).
Osteology provides insight into the biology of the enigmatic Antarctic notothenioid fish Gvozdarus svetovidovi
Authors: Eastman Joseph T. , Voskoboinikova Olga S. 
Published: August 2024

AbstractGvozdarus svetovidovi (Nototheniidae) is the rarest notothenioid fish, represented by only two specimens collected in 1970 and 1988. As it is little known, we present aspects of the cranial osteology of this species and use this, and other features of its morphology, to infer fundamental aspects of its biology. As in other pelagic nototheniids, G. svetovidovi has an elongated neurocranium and jaws but it does not have a paedomorphic skeleton. Although not unique to G. svetovidovi, the bones of the skull have some well-developed ridges for support and possibly for containment of subcutaneous fat. The skeleton is most similar to that of Dissostichus. G. svetovidovi has a high fat content, primarily within the trunk musculature and in a layer over the skull. It is probably neutrally buoyant in mesopelagic waters, where it has been captured at 295–550 m depth north of the Antarctic Slope Front (approximately the shelf break) and south of the southern boundary of the Antarctic Circumpolar Current. It likely relies on vision and mechanosensation to detect its prey, including bioluminescent, energy-dense myctophids and krill in this resource-rich area of the Southern Ocean. Strays near shelf waters feed on Pleuragramma antarcticum. G. svetovidovi is unlike all other notothenioids in fundamental aspects of its biology including its habitat, diet and distribution. Although it may be on the path to extinction, if our postulated life history of G. svetovidovi is accurate, it expands the current perception of the bounds of the notothenioid radiation into a locality in the Southern Ocean not previously known to be occupied by this group.
Resilience of turbid coral communities to marine heatwave
Authors: Zweifler Adi , Dee Shannon , Browne Nicola K. 
Published: August 2024

AbstractHigh sea surface temperatures recorded in summer 2021 introduced a unique opportunity for ‘real-time’ assessment of Exmouth Gulf turbid reef’s resilience to a marine heatwave event. Four sites along a turbidity and temperature gradient were surveyed during (March 2021) and after (October 2021) the event to assess bleaching rates (Bleaching Index = BI), differences in coral morphological responses to the heat wave, and post-event changes in benthic and coral community structure. Despite experiencing higher temperatures (> 30 °C) and Degree Heating Weeks (DHW = 8), the most turbid reef site, Somerville, displayed greater resilience to heat stress (BI = 14) compared to the “clear water” site, Bundegi (BI = 19.3), where temperatures never exceeded 30 °C (3 DHW). Our results also reveal that encrusting and massive corals, often considered more resilient to bleaching, displayed increased bleaching susceptibility at the turbid sites, potentially due to the synergistic effects of sedimentation and heat stress. In contrast, branching and foliose corals showed greater resilience to the heat wave in turbid water settings, while encrusting and branching corals exhibited lower resilience in the clearwater site. These findings highlight complex interactions between heat and reduced UV stress on turbid reefs potentially increasing resilience to bleaching but likely only for those coral morphologies that are not heavily impacted by sedimentation.
Characteristics of pelvic obliquity in dysplastic hip osteoarthritis
Authors: Ozawa Yuto , Osawa Yusuke , Takegami Yasuhiko , Funahashi Hiroto , Tanaka Shinya , Imagama Shiro 
Published: August 2024

Abstract
Purpose
Factors affecting direction of pelvic obliquity (PO) in dysplastic hip osteoarthritis (DHOA) remains unclear. This retrospective cohort study evaluates morphological characteristics, spinal alignment, and hip function in patients with unilateral DHOA.

Methods
Between 2018 and 2022, 104 patients with unilateral DHA were enrolled. Patients were categorized into flat PO (F-PO group; PO < 2°), affected side PO (A-PO group; PO downward by ≥ 2°), and unaffected side PO (U-PO group; PO upward by ≥ 2°). Demographics, radiographic hip and lower limb parameters, spinal parameters, and functional scores were compared between the groups.

Results
There were 39, 44, and 21 patients in the F-PO, A-PO, and U-PO group, respectively. The subluxation percentage of Crowe classification showed a significant difference among the three groups. The femoral head lateralization distance was significantly greater in the U-PO group than in the F-PO and A-PO groups. Furthermore, the hip adduction angle was significantly lower in the A-PO group than in the F-PO and U-PO groups. The lumbar scoliosis angle was significantly different between the groups. In multivariate analysis, hip adduction angle was extracted as an independent factor associated with the A-PO. Age, subluxation percentage, and hip adduction angle were identified as independent factors associated with the U-PO. Harris hip score was significantly poorer in U-PO group than in F-PO group.

Conclusions
Hip adduction angle influenced A-PO, while age, subluxation percentage, and hip adduction angle influenced U-PO; lumbar scoliosis angle was associated with PO direction. U-PO patients had poorer functional scores, indicating the impact of hip contracture and subluxation on PO direction in DHOA.
Natural history of non-polyglutamine CACNA1A disease in Austria
Authors: Indelicato Elisabetta , Nachbauer Wolfgang , Amprosi Matthias S. , Maier Sarah , Unterberger Iris , Delazer Margarete , Kaltseis Katharina , Kiechl Stefan , Broessner Gregor , Baumann Matthias , Boesch Sylvia 
Published: August 2024

Abstract
Background and objectives
Non-polyglutamine CACNA1A variants underlie an extremely variable phenotypic spectrum encompassing developmental delay, hemiplegic migraine, epilepsy, psychiatric symptoms, episodic and chronic cerebellar signs. We provide our experience with the long-term follow-up of CACNA1A patients and their response to interval therapy.

Methods
Patients with genetically confirmed non-polyglutamine CACNA1A disease were prospectively followed at the Center for Rare Movement Disorders of the Medical University of Innsbruck from 2004 to 2024.

Results
We recruited 41 subjects with non-polyglutamine CACNA1A disease, of which 38 (93%) familial cases. The mean age at the first examination was 35 ± 22 years. Disease onset was in the childhood/adolescence in 31/41 patients (76%). Developmental delay and episodic symptoms were the first disease manifestation in 9/41 (22%) and 32/41 (78%) patients respectively. Chronic neurological signs encompassed a cerebellar syndrome in 35/41 (85%), which showed almost no progression during the observation period, as well as cognitive deficits in 9/20 (45%, MOCA test score < 26), psychiatric and behavioral symptoms in 11/41(27%). Seizures occurred in two patients concomitant to severe hemiplegic migraine. At the last visit, 27/41 patients (66%) required an interval prophylaxis (including acetazolamide, flunarizine, 4-aminopyridine, topiramate), which was efficacious in reducing the frequency and severity of episodic symptoms in all cases. In one patient in his 70ies with progressively therapy resistant hemiplegic migraine, treatment with the anti-CGRP antibody galcanezumab successfully reduced the frequency of migraine days from 4 to 1/month.

Conclusions
Non-polyglutamine CACNA1A disease show an evolving age-dependent presentation. Interval prophylaxis is effective in reducing the burden of episodic symptoms.