bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Brother Albert’: Albert Erskine, Malcolm Lowry, and the Editing of Under the Volcano
Authors: King Daniel Robert 
Published: August 2024

Abstract
In this essay, I draw on a range of archival sources to examine the working relationship between the modernist author Malcolm Lowry and the literary editor Albert Erskine. I examine Erskine’s editing of Lowry’s Under the Volcano (1947) at the firm Reynal and Hitchcock and unpack Erskine’s input into the final shape of the novel. Erskine worked with Lowry extensively on the manuscript of Under the Volcano in 1946 and 1947 and oversaw several significant changes to the text. In this essay, I examine Erskine’s approach to literary editing, exploring its origins in the New Criticism of Robert Penn Warren and Cleanth Brooks, and Erskine’s negotiations between the practicalities and demands of commercial postwar publishing and Lowry’s exacting and experimental approach to his work. In doing so, I explore firstly how Erskine’s literary editing was shaped by his training in a particularly American form of New Criticism and, secondly, how these editorial principles were carried out and shaped the final form of Under the Volcano.
The Challenge of Evaluating the Impact of NGOs on the Human Capital and Life Satisfaction of Syrian Refugees in Turkey
Authors: Kırkıç Ayşe Perihan 
Published: August 2024

Abstract
The number of projects designed by non-governmental organisations (NGOs) to meet refugees’ needs in Turkey has steadily increased since the arrival of Syrian refugees. In existing studies, the projects of NGOs working with Syrian refugees have not been evaluated from a lens of human capital and life satisfaction. Given the crucial role of NGOs in implementing social policies within host countries, it becomes imperative to conduct thorough analyses of the effects of their projects on the target groups. The objective of this study is to evaluate the significance of human capital and life satisfaction within NGO projects, as perceived by NGO employees. Semi-structured interviews were conducted with national and international NGO representatives in Istanbul to probe the impact of the projects on Syrian refugees. Based on the findings, despite the considerable number of projects carried out with Syrian refugees, the absence of a dedicated methodology to measure changes in participants’ human capital and life satisfaction poses significant challenges in evaluating project outcomes. In this research, I propose a five-step method for assessing the impacts of NGO-applied projects. This method acknowledges existing limitations and promotes the improvement of the evaluation process.
Static and Dynamic Dysconnectivity in Early Psychosis: Relationship With Symptom Dimensions
Authors: Cattarinussi Giulia , Grimaldi David Antonio , Aarabi Mohammad Hadi , Sambataro Fabio 
Published: August 2024

Abstract

Background and Hypothesis
Altered functional connectivity (FC) has been frequently reported in psychosis. Studying FC and its time-varying patterns in early-stage psychosis allows the investigation of the neural mechanisms of this disorder without the confounding effects of drug treatment or illness-related factors.

Study Design
We employed resting-state functional magnetic resonance imaging (rs-fMRI) to explore FC in individuals with early psychosis (EP), who also underwent clinical and neuropsychological assessments. 96 EP and 56 demographically matched healthy controls (HC) from the Human Connectome Project for Early Psychosis database were included. Multivariate analyses using spatial group independent component analysis were used to compute static FC and dynamic functional network connectivity (dFNC). Partial correlations between FC measures and clinical and cognitive variables were performed to test brain-behavior associations.

Study Results
Compared to HC, EP showed higher static FC in the striatum and temporal, frontal, and parietal cortex, as well as lower FC in the frontal, parietal, and occipital gyrus. We found a negative correlation in EP between cognitive function and FC in the right striatum FC (pFWE = 0.009). All dFNC parameters, including dynamism and fluidity measures, were altered in EP, and positive symptoms were negatively correlated with the meta-state changes and the total distance (pFWE = 0.040 and pFWE = 0.049).

Conclusions
Our findings support the view that psychosis is characterized from the early stages by complex alterations in intrinsic static and dynamic FC, that may ultimately result in positive symptoms and cognitive deficits.
Schizophrenia and Neurodevelopment: Insights From Connectome Perspective
Authors: Sun Xiaoyi , Xia Mingrui 
Published: August 2024

Abstract

Background
Schizophrenia is conceptualized as a brain connectome disorder that can emerge as early as late childhood and adolescence. However, the underlying neurodevelopmental basis remains unclear. Recent interest has grown in children and adolescent patients who experience symptom onset during critical brain development periods. Inspired by advanced methodological theories and large patient cohorts, Chinese researchers have made significant original contributions to understanding altered brain connectome development in early-onset schizophrenia (EOS).

Study Design
We conducted a search of PubMed and Web of Science for studies on brain connectomes in schizophrenia and neurodevelopment. In this selective review, we first address the latest theories of brain structural and functional development. Subsequently, we synthesize Chinese findings regarding mechanisms of brain structural and functional abnormalities in EOS. Finally, we highlight several pivotal challenges and issues in this field.

Study Results
Typical neurodevelopment follows a trajectory characterized by gray matter volume pruning, enhanced structural and functional connectivity, improved structural connectome efficiency, and differentiated modules in the functional connectome during late childhood and adolescence. Conversely, EOS deviates with excessive gray matter volume decline, cortical thinning, reduced information processing efficiency in the structural brain network, and dysregulated maturation of the functional brain network. Additionally, common functional connectome disruptions of default mode regions were found in early- and adult-onset patients.

Conclusions
Chinese research on brain connectomes of EOS provides crucial evidence for understanding pathological mechanisms. Further studies, utilizing standardized analyses based on large-sample multicenter datasets, have the potential to offer objective markers for early intervention and disease treatment.
Where are inequalities produced? Comparing the variations of graduate employment between the UK’s districts and universities
Authors: Yu Yang 
Published: August 2024

Abstract
This study presents the first set of estimates of inequalities in high-status employment between UK districts and universities. Making use of graduate data from the Higher Education Statistics Agency, this study compares how graduates’ employment and social mobility vary based on their place of origin and the university attended. Inequality and social mobility are measured by the chance of entering a higher professional occupation 15 months after graduation. The results showed that the occupation inequalities between universities were much larger than those between local authority districts, indicating that our higher education system is evidently (re)producing an even greater amount of inequality than spatial disparities. These findings contribute to the emerging academic and policy narrative regarding the social and geographic inequalities in the UK, addressing the inequalities in graduate employment across universities may be crucial in meeting the demands of the labor market and driving upward mobility throughout the country.
A molecular mechanism for angiotensin II receptor blocker‐mediated slit membrane protection: Angiotensin II increases nephrin endocytosis via AT1‐receptor‐dependent ERK 1/2 activation
Authors: Königshausen Eva , Zierhut Ulf M. , Ruetze Martin , Rump Lars C. , Sellin Lorenz 
Published: August 2024

AbstractAlbuminuria is characterized by a disruption of the glomerular filtration barrier, which is composed of the fenestrated endothelium, the glomerular basement membrane, and the slit diaphragm. Nephrin is a major component of the slit diaphragm. Apart from hemodynamic effects, Ang II enhances albuminuria by β‐Arrestin2‐mediated nephrin endocytosis. Blocking the AT1 receptor with candesartan and irbesartan reduces the Ang II‐mediated nephrin‐β‐Arrestin2 interaction. The inhibition of MAPK ERK 1/2 blocks Ang II‐enhanced nephrin‐β‐Arrestin2 binding. ERK 1/2 signaling, which follows AT1 receptor activation, is mediated by G‐protein signaling, EGFR transactivation, and β‐Arrestin2 recruitment. A mutant AT1 receptor defective in EGFR transactivation and β‐Arrestin2 recruitment reduces the Ang II‐mediated increase in nephrin β‐Arrestin2 binding. The mutation of β‐Arrestin2K11,K12, critical for AT1 receptor binding, completely abrogates the interaction with nephrin, independent of Ang II stimulation. β‐Arrestin2K11R,K12R does not influence nephrin cell surface expression. The data presented here deepen our molecular understanding of a blood‐pressure‐independent molecular mechanism of AT‐1 receptor blockers (ARBs) in reducing albuminuria.
Association Between Clubfoot and Neonatal Abstinence Syndrome in the United States, 2018–2022
Authors: Dhodapkar Meera M. , Jonnalagadda Anshu , Socci Adrienne R. , Franklin Corinna 
Published: August 2024

Purpose:
The United States has seen an increase in opioid use and misuse over the last 2 decades. Infants have been impacted by the opioid epidemic, with a reported 5-fold increase in the incidence of neonatal abstinence syndrome (NAS) over the last 2 decades. There are many conditions associated with NAS, and thus, the current study sought to examine the association between NAS and clubfoot.

Methods:
The study was retrospective, utilizing patient data from the Pediatric Hospital Information System (PHIS) database. Neonates presenting to any PHIS hospital between 2018 and 2022 were identified and included in the study. Patients with NAS and clubfoot were identified utilizing the International Classification of Diseases (ICD)-9 and 10 codes. Univariable and multivariable analyses were performed to investigate associations between clubfoot, race, ethnicity, insurance type, gestational age, length of stay, NAS, and comorbidity burden.

Results:
A total of 458,274 patients were identified, of whom 2337 (0.5%) had a clubfoot diagnosis and 5431 (1.2%) had a diagnosis of NAS. Multivariable logistic regression revealed higher independent odds of clubfoot among patients with a diagnosis of NAS [odds ratio (OR): 1.49], patients with a greater number of comorbidities (OR: 4.75 for 1 comorbidity vs. none, and 21.19 for 2+ comorbidities, vs. none), patients with a greater gestational age (OR: 1.01 per week increase), and those with an increased length of stay (OR: 1.00 per day increase). A lower independent odds of clubfoot was observed among patients of Asian race (OR: 0.66), Hispanic/Latino ethnicity (OR: 0.80), non-Hispanic Black (OR: 0.75), and multiracial (OR: 0.80) ethnicity/race relative to non-Hispanic/Latino White patients (P<0.05 for all).

Conclusion:
Patients with a diagnosis of NAS demonstrated higher odds of clubfoot, in addition to sociodemographic factors, as well as comorbidity burden.
Long-term Outcomes of Intramedullary Nails in Osteogenesis Imperfecta: Fewer Surgeries and Longer Survival Times With Telescoping Rods in Patients With Over Ten Years Follow-up
Authors: Nguyen Cynthia V. , Makarewich Christopher A. , Poon Selina C. , Cho Robert H. , Hennessey Theresa A. 
Published: August 2024

Objective:
Intramedullary rodding of lower extremity long bones in patients with osteogenesis imperfecta (OI) is a widely accepted technique for fracture treatment and prevention. Previous small studies with short to medium-term follow-up have shown that telescoping rods have longer survival times compared with static rods. However, there are no long-term studies (10 or more years) longitudinally evaluating the results of these procedures. The purpose of this study was to compare the rod survival duration and number of procedures in patients treated with static versus telescoping rods with 10 years minimum follow-up.

Methods:
This was a multicenter retrospective comparative study of patients with a diagnosis of OI who had intramedullary nailing of the femur and/or tibia. Each bone included in the study had a 10-year minimum follow-up, only one type of rod utilized over the follow-up period, and no rod replacement surgeries outside of the primary hospital system. Patient demographics, clinical data, and details of each procedure were obtained. Groups were compared using univariate analysis with a 2-independent samples t test for continuous variables, χ2 for categorical variables, and the Kaplan-Meier method for survival analysis.

Results:
A total of 119 bones in 52 patients met inclusion criteria. Average follow up was 13.1 (range: 10.2 to 18.4) years. There were no differences between groups in follow-up length, Sillence type, bisphosphonate use, or age at first-rod placement. There were significantly more tibias treated in the static rod group compared with the telescopic rod group. The average survival length was significantly longer for telescopic rods, 5.8 ± 3.9 years versus 4.0±3.6 years for static rods. On average, bones treated with telescopic rods had significantly fewer surgeries compared with static rods (2.2 ± 0.8 vs 3.3 ± 1.6).

Conclusion:
At long term follow up, bone segments in patients with OI treated with telescopic rods required fewer surgeries and had longer implant survival times compared with those treated with static rods. When available, surgeons should consider telescopic rods as the initial implant choice in this patient population.
Association of Plasma Cabozantinib Concentration With Treatment Response and Adverse Events in Japanese Patients With Advanced Renal Cell Carcinoma
Authors: Maruyama Shinichi , Kobayashi Hiroaki , Hiraga Tatsuru , Anno Tadatsugu , Sanjo Tansei , Arai Masashi , Ishida Masaru , Kanno Hiroshi , Kato Masaru 
Published: August 2024

Background:
Cabozantinib is highly effective against advanced renal cell carcinoma (RCC). However, approximately 60% of the patients require a dose reduction due to severe adverse events. Although associations between trough concentrations of cabozantinib and its efficacy and safety have been reported in other countries, reports on Japanese patients are unavailable. Therefore, we investigated the association of cabozantinib trough concentration with therapeutic efficacy and adverse events in Japanese patients with RCC and evaluated the usefulness of therapeutic drug monitoring.

Methods:
In this prospective observational study, we measured the trough concentrations of cabozantinib in 10 Japanese patients with RCC enrolled between May 2022 and September 2023. The associations of trough concentration with treatment response, as determined by RECIST 1.1, and the occurrence of grade 2 or higher adverse events were assessed.

Results:
Trough concentration was higher in patients with controlled cancer than in those with progressive cancer (1024 ± 352 versus 457 ± 216 ng/mL, P = 0.035). In addition, patients with grade 2 or higher adverse events showed a significantly higher trough concentration than those without (1560 ± 513 versus 807 ± 319 ng/mL, P = 0.032). In particular, grade 2 or higher dysgeusia, anorexia, fatigue, and dyspepsia significantly correlated with trough concentrations.

Conclusions:
This is the first clinical study to demonstrate a correlation between cabozantinib trough concentration, therapeutic efficacy, and adverse events in Japanese patients with RCC. The therapeutic drug monitoring of cabozantinib could be useful for improving therapeutic efficacy and avoiding serious adverse events.
Perspectives and Factors Related to Pre-exposure Prophylaxis Use Among Young Men Who Have Sex With Men in the United States: A Mixed-Methods Study on the Role of History of PrEP Use
Authors: Ma Junye , Soberano Zach , Stamp Bryce F. , Rosso Matthew , Hightow-Weidman Lisa , Powers Kimberly A. , Stocks Jacob Benjamin , Hosek Sybil , Horvath Keith J. 
Published: August 2024

Abstract
This study quantitatively examined factors related to young men who have sex with men (YMSM)'s decisions to use pre-exposure prophylaxis (PrEP) by their history of PrEP use and qualitatively elicited their perspectives on PrEP options. Higher proportions of YMSM who had never used (vs. ever used) PrEP considered the following factors as important in their decisions to use PrEP: (a) Returning to PrEP follow-up visits (p = .02), (b) having to talk about sex/PrEP with providers (p = .013), (c) people assuming they are infected with HIV (p = .021), (d) family finding out about their PrEP use (p = .001), and (e) friends finding out about their PrEP use (p = .008). Through inductive content analysis, qualitative data showed that a higher proportion of YMSM who had never used PrEP (vs. ever used) expressed concerns about HIV stigma from nonaffirming health care providers and the potential risk of inadvertently revealing their LGBTQ+ identity to others, which were described as potential barriers to PrEP use. Overall, our findings suggest that future interventions may consider tailoring PrEP messaging to YMSM's history of PrEP use, which may ultimately increase PrEP uptake and adherence.
Distinct features of immune activation and exhaustion markers in people with perinatally acquired HIV
Authors: Taramasso Lucia , Dentone Chiara , Cama Isabella , Fenoglio Daniela , Altosole Tiziana , Parodi Alessia , Campi Cristina , Piana Michele , Mora Sara , Giacomini Mauro , Labate Laura , Garbarino Sara , Bruzzone Bianca , Filaci Gilberto , Bassetti Matteo , Di Biagio Antonio 
Published: August 2024

Objective:
The aim of this study was to characterize T-cell activation, exhaustion, maturation and Treg frequencies in individuals who acquire perinatal HIV (PHIV), in individuals who acquired HIV as adult (AHIV), and in healthy controls.

Design:
This cross-sectional study included people with HIV at least 14 and younger than 40 years, HIV-RNA less than 50 copies/ml on antiretroviral therapy for at least 6 months, and HC.

Methods:
We assessed the expression of PD-1, TIM-3, EOMES, CD38+ DR+, maturation status by CD4+ and CD8+ T cells and the frequency of CD4+ and CD8+ Treg cells. Principal component analysis (PCA) and k-means cluster analysis investigated which combination of immunological parameters better associated with each group.

Results:
Twenty-six PHIV and 18 AHIV with median ages of 26 (8.0) and 28 (6.8) years were consecutively enrolled. PHIV showed significant higher frequency of naive and lower frequency of terminal effector memory CD4+ and CD8+ T cells than AHIV. AHIV exhibited higher expression of exhaustion and activation markers. The statistical analysis returned two clusters with 94% of specificity and 88% of sensitivity identifying PHIV vs. AHIV. The nine healthy controls had a lower expression of exhaustion markers on both CD4+ and CD8+ T lymphocytes than PHIV and AHIV.

Conclusion:
These data may exclude major alterations of lymphopoiesis in PHIV, with even lower state of immune-activation and exhaustion compared with AHIV. This suggests that recent lack of virological control, may affect immune activation and exhaustion of CD4+ and CD8+ T cells.
GENETIC ABLATION OF THE C-TYPE LECTIN RECEPTOR CLEC2D INCREASES PERITONITIS MORTALITY, INFLAMMATION, AND PHYSIOLOGY WITHOUT DIMINISHING ORGAN INJURY
Authors: Stolarski Allan E. , Lai Jiann-Jyh , Kim Jiyoun , Rock Kenneth L. , Remick Daniel 
Published: August 2024

ABSTRACTBackground:Sepsis accounts for substantial morbidity and mortality motivating investigators to continue the search for pathways and molecules driving the pathogenesis of the disease. The current study examined if the novel C-type lectin receptor (CLR), Clec2d, plays a significant role in the pathogenesis of sepsis.Methods:Clec2d knockout (KO) mice were fully backcrossed onto the C57/BL6 background. Acute endotoxemia was induced with an intraperitoneal injection of lipopolysaccharide (LPS). Sepsis was induced in two different models, cecal ligation and puncture (CLP) andPseudomonas aeruginosapneumonia. Both models were treated with antibiotics and fluid resuscitation. In the sepsis models, physiologic and hematologic measurements were measured at 24 h by collecting a small sample of peripheral blood. Mortality was followed for 14 days.Results: A total of 197 mice were studied, 58 wild type (WT) and 54 knock-out (KO) in the LPS model; 27 wild type and 21 KO mice in the CLP model; and 22 WT and 15 KO mice in the pneumonia model. Clec2d KO mice had greater mortality in the LPS and CLP studies but not the pneumonia model. There were significant differences in multiple parameters determined 24 h post sepsis between mice who subsequently died and those lived. Consistent with previous reports in the CLP model, higher concentrations of IL-6, increased numbers of peripheral blood lymphocytes and greater renal injury were found in the dying mice. In contrast, in the pneumonia model, IL-6 was higher in the surviving mice; however, the IL-6 levels in the pneumonia model (0.6 ± 0.3 ng/mL mean ± SEM) were less than 2% of the IL-6 levels of mice that died in the CLP model (41 ± 9 ng/mL, mean ± SEM). There were no differences in the lymphocyte count or renal injury between living and dying mice in the pneumonia model. In both sepsis models, dying mice had lower heart rates, respiratory rates, and body temperatures. These values were also lower in the KO mice compared to the WT in CLP, but the breath rate and body temperature were increased in the KO pneumonia mice.Conclusion:The C-type lectin receptor Clec2d plays a complicated role in the pathogenesis of sepsis, which varies with source of infection as demonstrated in the models used to study the disease. These data highlight the heterogeneity of the responses to sepsis and provide further evidence that a single common pathway driving sepsis organ injury and death likely does not exist.
Fat embolism syndrome after trauma: What you need to know
Authors: Kwon Junsik , Coimbra Raul 
Published: August 2024

ABSTRACT
Fat embolism syndrome refers to a systemic condition caused by the circulation of fat droplets in the bloodstream, reaching various target organs typically after major bone fractures or related surgical procedures. Although most cases resolve spontaneously, severe instances can lead to significant respiratory failure, neurological damage, and even mortality. Therefore, appropriate prevention, timely diagnosis, and management are crucial for trauma patients at risk. The objective of this review article is to explore the definition, epidemiology, risk factors, clinical presentation, and pathophysiology of fat embolism syndrome. Furthermore, it aims to examine current recommendations for the accurate diagnosis, prevention, and treatment of it, providing a comprehensive guide for the effective management of patients prone to this condition.