bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implications of Transnational Adoption Status for Adult Korean Adoptees
Authors: Langrehr Kimberly J. , Yoon Eunju , Hacker Jason , Caudill Kathy 
Published: January 2015

This study used a consensual qualitative research method to explore the implications of transnational adoption in the lives of 12 adult Korean adoptees. From the analysis, 6 domains emerged: (a) adoption history and preadoptive memories, (b) meaning of adoption, (c) adoptive family dynamics, (d) racism, (e) identity formation, and (f) counseling experiences. Results highlight the need for more awareness surrounding transnational adoption throughout the life span. Additional suggestions concerning research and practice are discussed.Este estudio usó un método de investigación cualitativa consensual para explorar las implicaciones de la adopción transnacional en las vidas de 12 adultos coreanos adoptados. A partir del análisis, surgieron 6 parámetros: (a) la historia de adopción y las memorias preadoptivas, (b) el significado de la adopción, (c) la dinámica de la familia adoptiva, (d) racismo, (e) formación de la identidad, y (f) experiencias en consejería. Los resultados destacan la necesidad de prestar mayor atención a la adopción transnacional a lo largo de toda la vida. Se discuten sugerencias adicionales relacionadas con la investigación y la práctica.
Foreign‐Born Therapists: How Acculturation and Supervisors' Multicultural Competence Are Associated With Clinical Self‐Efficacy
Authors: Kissil Karni , Davey Maureen , Davey Adam 
Published: January 2015

The authors examined the associations between acculturation, supervisors' multicultural competence, and clinicians' self‐efficacy in a sample of 153 immigrant therapists currently practicing in the United States. Participants completed a demographic questionnaire and 3 additional questionnaires that examined their levels of acculturation, perceived supervisors' multicultural competence, and clinical self‐efficacy. Results suggested that perceived prejudice, not level of acculturation, was significantly associated with foreign‐born therapists' clinical self‐efficacy. Perceived supervisors' multicultural competence was significantly associated with therapists' clinical self‐efficacy. Recommendations for supervisors working with foreign‐born therapists are provided.Los autores examinaron las asociaciones entre aculturación, competencia multicultural de los supervisores y autoeficacia de los profesionales clínicos en una muestra de 153 terapeutas inmigrantes actualmente en activo en los Estados Unidos. Los participantes completaron un cuestionario demográfico y tres cuestionarios adicionales que examinaron sus niveles de aculturación, la competencia multicultural percibida de sus supervisores y la autoeficacia clínica. Los resultados sugieren que los prejuicios percibidos, no el nivel de aculturación, están asociados de forma significativa con la autoeficacia clínica de los terapeutas nacidos en el extranjero. La competencia multicultural percibida de sus supervisores está asociada significativamente con la autoeficacia clínica de los terapeutas. Se proporcionan recomendaciones para supervisores que trabajan con terapeutas nacidos en el extranjero.
The Role of Internalized Stereotyping, Parental Pressure, and Parental Support on Asian Americans' Choice of College Major
Authors: Shen Frances C. 
Published: January 2015

The author explored the relationship between internalized stereotyping, parental pressure, and parental support on major choices among 315 Asian American undergraduate and graduate students. Results indicated that parental support, but not parental pressure, toward certain majors was associated with more stereotypical major choices. In addition, internalization of academic and career stereotypes was associated with more stereotypical major choices.El autor exploró la relación entre los estereotipos internalizados, la presión de los padres y el apoyo de los padres en la elección de estudios universitarios de 315 estudiantes de grado y posgrado asiático‐americanos. Los resultados indicaron que el apoyo de los padres, pero no la presión de los padres, hacia ciertas carreras está asociado con elecciones de estudios más estereotípicos. También, la internalización de estereotipos académicos y de carrera laboral está asociada con elecciones de estudios más estereotípicos.
Population pharmacokinetics of pomalidomide
Authors: Li Yan , Xu Yejun , Liu Liangang , Wang Xiaomin , Palmisano Maria , Zhou Simon 
Published: January 2015

AbstractA population pharmacokinetic (PPK) model of pomalidomide was developed and the influence of demographic and disease‐related covariates on PPK parameters was assessed based on data from 6 clinical trials of pomalidomide (dose range, 0.5–10 mg) in healthy participants (n = 96) and patients with multiple myeloma (MM; n = 144). PPK data described herein suggest that systemic clearance of pomalidomide is comparable between healthy study participants and patients with MM. However, apparent peripheral volume of distribution and apparent intercompartmental clearance between central and peripheral compartments were 8‐ and 3.7‐fold higher in patients with MM vs. healthy subjects, suggesting drug exposure is higher in peripheral compartments of patients with MM vs. healthy subjects. Covariate analysis suggested pomalidomide clearance is not affected by demographic factors except for gender, and it is unlikely this factor is clinically relevant. In addition, renal function as measured by creatinine clearance or renal impairment (RI) does not significantly affect clearance of pomalidomide. In conclusion, pomalidomide has robust pharmacokinetic exposure, not affected by demographic factors or renal impairment. Pomalidomide is preferentially taken up by tumors over healthy tissues in patients with MM.
Cost‐distance analysis of mesopredators as a tool for avian habitat restoration on a naturally fragmented landscape
Authors: Porter John H. , Dueser Raymond D. , Moncrief Nancy D. 
Published: January 2015

ABSTRACTRemoval of mammalian mesopredators is a strategy frequently applied to problems of conservation management, such as protection of rare or endangered species. Effectiveness of predator removal is often dependent on the ease with which additional predators can immigrate into the removal area. We applied cost‐distance analysis, coupled to a sensitivity analysis, and least‐cost path analysis to raccoons (Procyon lotor) and red foxes (Vulpes vulpes) on the Virginia barrier islands to determine the landscape resistance (i.e., difficulty) for mesopredators to reach individual islands from both mainland and island sources, to assess the relative role of mainland versus island populations as sources of immigrants to unoccupied (or depopulated) islands, and to formulate strategies that focus management efforts on a few key predator sources. The minimum energetic resistances to immigration varied over 3 orders of magnitude, making some islands better targets for removal efforts than others. Additionally, because of differences in the distribution of resident populations on the islands, resistance to immigration to a typical island is at least 3 times less for raccoons than for red foxes. Landscape resistance to red fox immigration is typically lower from the mainland, whereas for raccoons inter‐island movements are typically less costly. Empirical data from long‐term field studies of raccoons and red foxes in this system support the resistance structure identified. Overwater transits made by marked and resighted raccoons all were relatively short and relatively low‐cost. Similarly, islands that were recolonized following the removal of raccoons and red foxes all were characterized by very low resistance values. These results are used to identify specific islands for which predator removal efforts are most likely to be successful in aiding the recovery of beach‐nesting and colonial waterbirds in this system. A similar approach may be applied in any landscape where there are distinct differences in the costs of traversing different elements of the landscape. © 2015 The Wildlife Society.
What Is Left Unsaid: An Interpretive Description of the Information Needs of Parents of Children With Asthma
Authors: Archibald Mandy M. , Caine Vera , Ali Samina , Hartling Lisa , Scott Shannon D. 
Published: January 2015

AbstractParents of children with asthma provide the vast majority of day‐to‐day asthma care. Understanding their information needs is an essential step to provide meaningful and effective family‐centered asthma education. To gain insight into the information needs and information deficits of parents of children with asthma, we conducted an interpretive descriptive study to capture the perspectives of 21 parents from diverse backgrounds whose 23 children with asthma had a range of illness trajectories and management scenarios. Parents were purposively sampled from two asthma clinics and one pediatric emergency department in a large urban center in North America. Semi‐structured interviews were conducted in 2011–2012. In data analysis, parents’ self‐identified information needs were distinguished from analysts’ interpretations of information deficits. Participants’ knowledge did not always reflect time since diagnosis, and information needs and deficits persisted for years. Parents often reported receiving little or no little or no education about asthma and its management. An asthma management information hierarchy was identified, starting with the most foundational, recognizing severity; followed by acute management; prevention versus crisis orientation; and knowing “about” asthma. In the absence of adequate and accurate education, parents’ beliefs about the nature of asthma as an acute rather than chronic condition shaped their asthma management decisions and information‐seeking behaviors. Information deficits were affected by interactions with health care providers. These parents’ pervasive unmet information needs and deficits highlight the need for comprehensive, problem‐oriented asthma education. © 2015 Wiley Periodicals, Inc.
Synthesis and Characterization of CeO2 Nanoparticles via Solution Combustion Method for Photocatalytic and Antibacterial Activity Studies
Authors: Ravishankar Thammadihalli Nanjundaiah , Ramakrishnappa Thippeswamy , Nagaraju Ganganagappa , Rajanaika Hanumanaika 
Published: January 2015

AbstractCeO2 nanoparticles have been proven to be competent photocatalysts for environmental applications because of their strong redox ability, nontoxicity, long‐term stability, and low cost. We have synthesized CeO2 nanoparticles via solution combustion method using ceric ammonium nitrate as an oxidizer and ethylenediaminetetraacetic acid (EDTA) as fuel at 450 °C. These nanoparticles exhibit good photocatalytic degradation and antibacterial activity. The obtained product was characterized by various techniques. X‐ray diffraction data confirms a cerianite structure: a cubic phase CeO2 having crystallite size of 35 nm. The infrared spectrum shows a strong band below 700 cm−1 due to the Ce−O−Ce stretching vibrations. The UV/Vis spectrum shows maximum absorption at 302 nm. The photoluminescence spectrum shows characteristic peaks of CeO2 nanoparticles. Scanning electron microscopy (SEM) images clearly show the presence of a porous network with a lot of voids. From transmission electron microscopy (TEM) images, it is clear that the particles are almost spherical, and the average size of the nanoparticles is found to be 42 nm. CeO2 nanoparticles exhibit photocatalytic activity against trypan blue at pH 10 in UV light, and the reaction follows pseudo first‐order kinetics. Finally, CeO2 nanoparticles also reduce CrVI to CrIII and show antibacterial activity against Pseudomonas aeruginosa.
Direct fungal fermentation of lignocellulosic biomass into itaconic, fumaric, and malic acids: current and future prospects
Authors: Mondala Andro H 
Published: January 2015

Abstract
Various economic and environmental sustainability concerns as well as consumer preference for bio-based products from natural sources have paved the way for the development and expansion of biorefining technologies. These involve the conversion of renewable biomass feedstock to fuels and chemicals using biological systems as alternatives to petroleum-based products. Filamentous fungi possess an expansive portfolio of products including the multifunctional organic acids itaconic, fumaric, and malic acids that have wide-ranging current applications and potentially addressable markets as platform chemicals. However, current bioprocessing technologies for the production of these compounds are mostly based on submerged fermentation, which necessitates physicochemical pretreatment and hydrolysis of lignocellulose biomass to soluble fermentable sugars in liquid media. This review will focus on current research work on fungal production of itaconic, fumaric, and malic acids and perspectives on the potential application of solid-state fungal cultivation techniques for the consolidated hydrolysis and organic acid fermentation of lignocellulosic biomass.
The responses of hypothalamic NPY and OBRb mRNA expression to food deprivation develop during the neonatal‐prepubertal period and exhibit gender differences in rats
Authors: Matsuzaki Toshiya , Iwasa Takeshi , Tungalagsuvd Altankhuu , Munkhzaya Munkhsaikhan , Kawami Takako , Yamasaki Mikio , Murakami Masahiro , Kato Takeshi , Kuwahara Akira , Yasui Toshiyuki , Irahara Minoru 
Published: January 2015

AbstractNeuropeptide Y (NPY) is an important hypothalamic orexigenic neuropeptide that acts in the brain. It has been established that the fasting‐induced up‐regulation of NPY expression is mainly caused by a reduction in the activity of leptin, which is a hormone secreted by adipose tissue. We have reported that in female rats hypothalamic NPY mRNA expression does not respond to fasting during the early neonatal period, but subsequently becomes sensitive to it later in the neonatal period. In this study, we compared the developmental changes in the responses of NPY and leptin expression to fasting between male and female rats during the neonatal to pre‐pubertal period. Fasting was induced by maternal deprivation during the pre‐weaning period (postnatal days 10 and 20) and by food deprivation during the post‐weaning period (postnatal day 30). Hypothalamic NPY mRNA expression was not affected by fasting on postnatal day 10, whereas it was increased by fasting on postnatal day 20 and 30 in both males and females. On the other hand, the serum leptin level was decreased by fasting at all examined ages in both sexes. Namely, hypothalamic NPY mRNA expression was not correlated with the reduction in the serum leptin level at postnatal day 10 in either sex. Under the fasted conditions, the hypothalamic NPY mRNA levels of the males were higher than those of the females on postnatal days 20 and 30, whereas no such differences were observed under the normal nourishment conditions. The serum leptin levels observed under the fasted conditions did not differ between males and females at any examined age. These results suggest that some hypothalamic NPY functions develop during the neonatal period and that there is no major difference between the sexes with regard to the time when NPY neurons become sensitive to fasting. They also indicate that hypothalamic NPY expression is more sensitive to under‐nutrition in male rats than in female rats, at least during the pre‐pubertal period.
Protein design algorithms predict viable resistance to an experimental antifolate
Authors: Reeve Stephanie M. , Gainza Pablo , Frey Kathleen M. , Georgiev Ivelin , Donald Bruce R. , Anderson Amy C. 
Published: January 2015

Significance
Computationally predicting drug resistance mutations early in the discovery phase would be an important breakthrough in drug development. The most meaningful predictions of target mutations will show reduced affinity for the drug while maintaining viability in the complex context of a cell. Here, the protein design algorithm K* in Osprey was used to predict a single-nucleotide polymorphism in the target dihydrofolate reductase that confers resistance to an experimental antifolate in the preclinical discovery phase. Excitingly, the mutation was also selected in bacteria under antifolate pressure, confirming the prediction of a viable molecular response to external stress.
Percolation transition in dynamical traffic network with evolving critical bottlenecks
Authors: Li Daqing , Fu Bowen , Wang Yunpeng , Lu Guangquan , Berezin Yehiel , Stanley H. Eugene , Havlin Shlomo 
Published: January 2015

Significance
The transition between free flow and congestions in traffic can be observed in our daily life. Although this traffic phenomenon is well studied in highways, traffic in a network scale (representing a city) is far from being understood. A fundamental unsolved question is how the global flow in a city is being integrated from local flows. Here, we identify a fundamental mechanism of traffic organization in a network scale as a percolation process, and we show how global traffic breaks down when identified bottlenecks are congested. These bottlenecks evolve with time according to traffic dynamics and are different from structural bottleneck links found by traditional network analysis. Improvement of traffic on these bottlenecks can significantly improve the global traffic.
Purification and characterization of Fab fragments with rapid reaction kinetics against myoglobin
Authors: Song Hyung-Nam , Kim Dong-Hyung , Park Sung-Goo , Lee Myung Kyu , Paek Se-Hwan , Woo Eui-Jeon 
Published: January 2015

AbstractMyoglobin is an early biomarker for acute myocardial infarction. Recently, we isolated the antibody IgG-Myo2-7ds, which exhibits unique rapid reaction kinetics toward human myoglobin antigen. Antibodies with rapid dissociation kinetics are thought to be premature IgG forms that are produced during the early stage of in vivo immunization. In the present study, we identified the epitope region of the IgG-Myo2-7ds antibody to be the C-terminal region of myoglobin, which corresponds to 144–154 aa. The Fab fragment was directly purified by papain cleavage and protein G affinity chromatography and demonstrated kinetics of an association constant of 4.02 × 104 M−1 s−1 and a dissociation constant of 2.28 × 10−2 s−1, which retained the unique reaction kinetics of intact IgG-Myo2-7ds antibodies. Because a rapid dissociation antibody can be utilized for antibody recycling, the results from this study would provide a platform for the development of antibody engineering in potential diagnostic areas such as a continuous monitoring system for heart disease.
Mechanism for the antibacterial action of epigallocatechin gallate (EGCg) on Bacillus subtilis
Authors: Nakayama Motokazu , Shimatani Kanami , Ozawa Tadahiro , Shigemune Naofumi , Tomiyama Daisuke , Yui Koji , Katsuki Mao , Ikeda Keisuke , Nonaka Ai , Miyamoto Takahisa 
Published: January 2015

Abstract
Catechins are a class of polyphenols and have high anti-bacterial activity against various microorganisms. Here, we report the mechanism for antibacterial activity of epigallocatechin gallate (EGCg) against Gram-positive bacteria Bacillus subtilis, which is highly sensitive to EGCg. Transmission electron microscope analysis revealed that deposits containing EGCg were found throughout the cell envelope from the outermost surface to the outer surface of cytoplasmic membrane. Aggregating forms of proteins and EGCg were identified as spots that disappeared or showed markedly decreased intensity after the treatment with EGCg compared to the control by two-dimensional electrophoresis. Among the identified proteins included 4 cell surface proteins, such as oligopeptide ABC transporter binding lipoprotein, glucose phosphotransferase system transporter protein, phosphate ABC transporter substrate-binding protein, and penicillin-binding protein 5. Observations of glucose uptake of cells and cell shape B. subtilis after the treatment with EGCg suggested that EGCg inhibits the major functions of these proteins, leading to growth inhibition of B. subtilis.
The chromodomain-containing histone acetyltransferase TIP60 acts as a code reader, recognizing the epigenetic codes for initiating transcription
Authors: Kim Chul-Hong , Kim Jung-Woong , Jang Sang-Min , An Joo-Hee , Seo Sang-Beom , Choi Kyung-Hee 
Published: January 2015

Abstract
TIP60 can act as a transcriptional activator or a repressor depending on the cellular context. However, little is known about the role of the chromodomain in the functional regulation of TIP60. In this study, we found that TIP60 interacted with H3K4me3 in response to TNF-α signaling. TIP60 bound to H3K4me3 at the promoters of the NF-κB target genes IL6 and IL8. Unlike the wild-type protein, a TIP60 chromodomain mutant did not localize to chromatin regions. Because TIP60 binds to histones with specific modifications and transcriptional regulators, we used a histone peptide assay to identify histone codes recognized by TIP60. TIP60 preferentially interacted with methylated or acetylated histone H3 and H4 peptides. Phosphorylation near a lysine residue significantly reduced the affinity of TIP60 for the modified histone peptides. Our findings suggest that TIP60 acts as a functional link between the histone code and transcriptional regulators.
Extra tyrosine in the carbohydrate-binding module of Irpex lacteus Xyn10B enhances its cellulose-binding ability
Authors: Nishijima Hiroto , Nozaki Kouichi , Mizuno Masahiro , Arai Tsutomu , Amano Yoshihiko 
Published: January 2015

Abstract
The xylanase (Xyn10B) that strongly adsorbs on microcrystalline cellulose was isolated from Driselase. The Xyn10B contains a Carbohydrate-binding module family 1 (CBM1) (IrpCBMXyn10B) at N-terminus. The canonical essential aromatic residues required for cellulose binding were conserved in IrpCBMXyn10B; however, its adsorption ability was markedly higher than that typically observed for the CBM1 of an endoglucanase from Trametes hirsuta (ThCBMEG1). An analysis of the CBM-GFP fusion proteins revealed that the binding capacity to cellulose (7.8 μmol/g) and distribution coefficient (2.0 L/μmol) of IrpCBMXyn10B-GFP were twofold higher than those of ThCBMEG1-GFP (3.4 μmol/g and 1.2 L/μmol, respectively), used as a reference structure. Besides the canonical aromatic residues (W24-Y50-Y51) of typical CBM1-containing proteins, IrpCBMXyn10B had an additional aromatic residue (Y52). The mutation of Y52 to Ser (IrpCBMY52S-GFP) reduced these adsorption parameters to 4.4 μmol/g and 1.5 L/μmol, which were similar to those of ThCBMEG1-GFP. These results indicate that Y52 plays a crucial role in strong cellulose binding.
Small molecule-sensing strategy and techniques for understanding the functionality of green tea
Authors: Fujimura Yoshinori 
Published: January 2015

Abstract
Various low-molecular-weight phytochemicals in green tea (Camellia sinensis L.), especially (–)-epigallocatechin-3-O-gallate (EGCG), are known to be involved in health promotion and disease risk reduction. However, the underlying mechanism has remained elusive because of the absence of an analytical technique that can easily detect the precise behavior of such a small molecule. Recently, we have identified a cell-surface EGCG-sensing receptor and the related signaling molecules that control the physiological functions of EGCG. We also developed a novel in situ label-free imaging technique for visualizing spatially resolved biotransformations based on simultaneous mapping of EGCG and its phase II metabolites. Furthermore, we established a chemometric method capable of evaluating the functionality of multicomponent green tea extracts by focusing on their compositional balances. This review highlights our proposed small molecule-sensing techniques for detecting the complex behavior of green tea components and linking such information to an enhanced understanding of green tea functionality.