bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alberta Stroke Program Early Computed Tomography Score to Select Patients for Endovascular Treatment
Authors: Hill Michael D. , Demchuk Andrew M. , Goyal Mayank , Jovin Tudor G. , Foster Lydia D. , Tomsick Thomas A. , von Kummer Rüdiger , Yeatts Sharon D. , Palesch Yuko Y. , Broderick Joseph P. 
Published: December 2013

Background and Purpose—
The Interventional Management of Stroke (IMS)-III trial randomized patients with acute ischemic stroke to intravenous tissue-type plasminogen activator (tPA) plus endovascular therapy versus intravenous tPA therapy alone within 3 hours from symptom onset. A predefined secondary hypothesis was that subjects with significant early ischemic change on the baseline scan would not respond to endovascular therapy.

Methods—
The primary outcome was 90-day modified Rankin Scale score 0 to 2. The baseline and follow-up computed tomographic (CT) scan images were reviewed centrally and blinded to any clinical information. We assessed whether the baseline Alberta Stroke Program Early CT Score (ASPECTS) predicted outcome and interacted with study treatment. We analyzed subgroups defined by time from onset to intravenous tPA initiation and baseline occlusion status at a prespecified α=0.01.

Results—
Baseline demographic and clinical characteristics of 656 randomized patients were similar between subjects with a baseline ASPECTS 8 to 10 (58% of the study sample) versus 0 to 7. Subjects with ASPECTS 8 to 10 were almost twice as likely (relative risk, 1.8; 99% confidence interval, 1.4–2.4) to achieve a favorable outcome. There was insufficient evidence of a treatment-by-ASPECTS interaction. In those treated with onset to intravenous tPA <120 minutes, in CT angiography–proven internal carotid artery or middle cerebral artery occlusion, and in both, results were similar. The probability of achieving recanalization (arterial occlusion lesion, 2–3) of the primary arterial occlusive lesion (relative risk, 1.3; 99% confidence interval, 1.0–1.8) or achieving thrombolysis in cerebral ischemia score 2b/3 reperfusion (relative risk 2.0; 99% confidence interval, 1.2–3.2) was higher among subjects with higher ASPECTS.

Conclusions—
ASPECTS is a strong predictor of outcome and a predictor of reperfusion. ASPECTS did not identify a subpopulation of subjects that particularly benefitted from endovascular therapy immediately after routine intravenous tPA.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00359424.
Modeled Contrast in the Response of the Surface Energy Balance to Heat Waves for Forest and Grassland
Authors: Stap Lennert B. , van den Hurk Bart J. J. M. , van Heerwaarden Chiel C. , Neggers Roel A. J. 
Published: December 2013

Abstract
Observations have shown that differences in surface energy fluxes over grasslands and forests are amplified during heat waves. The role of land–atmosphere feedbacks in this process is still uncertain. In this study, a single-column model (SCM) is used to investigate the difference between forest and grassland in their energy response to heat waves. Three simulations for the period 2005–11 were carried out: a control run using vegetation characteristics for Cabauw (the Netherlands), a run where the vegetation is changed to 100% forest, and a run with 100% short grass as vegetation. A surface evaporation tendency equation is used to analyze the impact of the land–atmosphere feedbacks on evapotranspiration and sensible heat release under normal summer and heat wave conditions with excessive shortwave radiation.
Land–atmosphere feedbacks modify the contrast in surface energy fluxes between forest and grass, particularly during heat wave conditions. The surface resistance feedback has the largest positive impact, while boundary layer feedbacks generally tend to reduce the contrast. Overall, forests give higher air temperatures and drier atmospheres during heat waves. In offline land surface model simulations, the difference between forest and grassland during heat waves cannot be diagnosed adequately owing to the absence of boundary layer feedbacks.
Three-Dimensional Double-Ridge Internal Tide Resonance in Luzon Strait
Authors: Buijsman Maarten C. , Klymak Jody M. , Legg Sonya , Alford Matthew H. , Farmer David , MacKinnon Jennifer A. , Nash Jonathan D. , Park Jae-Hun , Pickering Andy , Simmons Harper 
Published: December 2013

Abstract
The three-dimensional (3D) double-ridge internal tide interference in the Luzon Strait in the South China Sea is examined by comparing 3D and two-dimensional (2D) realistic simulations. Both the 3D simulations and observations indicate the presence of 3D first-mode (semi)diurnal standing waves in the 3.6-km-deep trench in the strait. As in an earlier 2D study, barotropic-to-baroclinic energy conversion, flux divergence, and dissipation are greatly enhanced when semidiurnal tides dominate relative to periods dominated by diurnal tides. The resonance in the 3D simulation is several times stronger than in the 2D simulations for the central strait. Idealized experiments indicate that, in addition to ridge height, the resonance is only a function of separation distance and not of the along-ridge length; that is, the enhanced resonance in 3D is not caused by 3D standing waves or basin modes. Instead, the difference in resonance between the 2D and 3D simulations is attributed to the topographic blocking of the barotropic flow by the 3D ridges, affecting wave generation, and a more constructive phasing between the remotely generated internal waves, arriving under oblique angles, and the barotropic tide. Most of the resonance occurs for the first mode. The contribution of the higher modes is reduced because of 3D radiation, multiple generation sites, scattering, and a rapid decay in amplitude away from the ridge.
Impact of ASCAT Soil Moisture Assimilation on Regional Precipitation Forecasts: A Case Study for Austria
Authors: Schneider Stefan , Wang Yong , Wagner Wolfgang , Mahfouf Jean-Francois 
Published: December 2013

AbstractIn this study, remotely sensed soil moisture data from the Advanced Scatterometer (ASCAT) on board the Meteorological Operational (MetOp) series of satellites are assimilated in the regional forecasting model, Aire Limitée Adaptation Dynamique Développement International (ALADIN-Austria), using a simplified extended Kalman filter. A pointwise bias correction method is applied to the ASCAT data as well as quality flags prepared by the data provider. The ASCAT assimilation case study is performed over central Europe during a 1-month period in July 2009. Forecasts of those assimilation experiments are compared to the control run provided by the operational ALADIN version of the Austrian Met Service, Zentralanstalt für Meteorologie und Geodynamik (ZAMG). Forecasts are furthermore verified versus in situ data. For a single-day case study the ability of the approach to improve precipitation forecast quality in the presence of high impact weather is demonstrated. Results show that 1) based on a one station in situ data evaluation, soil moisture analysis is improved, compared to the operational analysis, when ASCAT soil moisture data is assimilated; 2) pointwise bias correction of the satellite data is beneficial for forecast quality; 3) screen level parameter forecasts can be slightly improved as a result of this approach; and 4) convective precipitation forecast is improved over flatland for the investigation period while over mountainous regions the impact is neutral.
Errors in Ensemble Kalman Smoother Estimates of Cloud Microphysical Parameters
Authors: Posselt Derek J. , Hodyss Daniel , Bishop Craig H. 
Published: December 2013

Abstract
If forecast or observation error distributions are non-Gaussian, the true posterior mean and covariance depends on the distribution of observation errors and the observed values. The posterior distribution of analysis errors obtained from ensemble Kalman filters and smoothers is independent of observed values. Hence, the error in ensemble Kalman smoother (EnKS) state estimates is closely linked to the sensitivity of the true posterior to observed values. Here a Markov chain Monte Carlo (MCMC) algorithm is used to document the dependence of the errors in EnKS-based estimates of cloud microphysical parameters on observed values. It is shown that EnKS analysis distributions are grossly inaccurate for nonnegative microphysical parameters when parameter values are close to zero. Furthermore, numerical analysis is presented that shows that, by design, the posterior distributions given by EnKS and even nonlinear extensions of these smoothers approximate the average of all possible posterior analysis distributions associated with all possible observations given the prior. Multiple runs of the MCMC are made to approximate this distribution. This empirically derived average of Bayesian posterior analysis errors is shown to be qualitatively similar to the EnKS posterior. In this way, it is demonstrated that, in the presence of nonlinearity, EnKS algorithms do not estimate the true posterior error distribution given the specific values of the observations. Instead, they produce an error distribution that is consistent with an average of the true posterior variance, weighted by the probability of obtaining each possible observation. This seemingly subtle distinction gives rise to fundamental differences between the approximate EnKS posterior and the true Bayesian posterior distribution.
Increasing Influence of Party Identification on Perceived Scientific Agreement and Support for Government Action on Climate Change in the United States, 2006–12
Authors: McCright Aaron M. , Dunlap Riley E. , Xiao Chenyang 
Published: December 2013

Abstract
Since the mid-2000s, U.S. conservative leaders and Republican politicians have stepped up efforts to challenge the reality and seriousness of anthropogenic climate change (ACC). Especially with the rise of the Tea Party in 2009, ACC denial has become something of a litmus test for Republican politicians to prove their conservative bona fides. Two recent studies find that misperception of scientific agreement on ACC is associated with lower levels of support for government action to deal with ACC. Using nationally representative survey data from 2006 and 2012, the analytical model developed in those two studies was applied to investigate whether the effect of political orientation on perceived scientific agreement and support for government action to reduce emissions has increased since the heightened ACC denial by Republican politicians beginning in 2009. The results indicated that political ideology and party identification are moderately strong predictors of perceived scientific agreement; beliefs about the timing, human cause, seriousness, and threat of global warming; and support for government action in both 2006 and 2012. Further, as expected, the effect of party identification on perceived scientific agreement and support for government action increased from 2006 and 2012, evidence that rank-and-file Republicans in the general public are more strongly embracing the ACC denial espoused by Republican politicians in recent years. Such increased partisanship poses a formidable barrier to public understanding of ACC.
Self-management interventions for people living with human immunodeficiency virus: A scoping review
Authors: Bernardin Kaitlyn N. , Toews Dorothea N. , Restall Gayle J. , Vuongphan Lynn 
Published: December 2013

Background. Self-management is an important emerging intervention for people with human immunodeficiency virus (PHAs). The principles of self-management are consistent with the principles of client-centred occupational therapy. Purpose. This scoping review addressed three questions about self-management interventions for PHAs: (a) What knowledge, skills, and attitudes are taught? (b) What outcomes are intended? (c) What are the participation experiences of PHAs? Method. Questions were searched in six databases. Two researchers independently reviewed abstracts and articles before inclusion. Extracted data were iteratively themed. Findings. Thirty-five articles were included. Interventions taught self-care, interpersonal skills, technical knowledge, cognitive skills, positive attitudes, planning for the future, and role management. Outcomes included well-being, health and illness management, and health services use. Participation experiences reflected social experiences, needs of PHAs, specific needs of women, participation, empowerment, intervention importance, and experiences with service delivery. Implications. Self-management interventions are a promising approach for occupational therapists to enable PHAs’ occupational performance goals.
Psychotherapy: A profile of current occupational therapy practice in Ontario
Authors: Moll Sandra E. , Tryssenaar Joyce , Good Colleen R. , Detwiler Lisa M. 
Published: December 2013

Background. Psychotherapy can be an important part of psychosocial occupational therapy practice; however, it requires specialized training to achieve and maintain competence. Regulation varies by province, and in Ontario, occupational therapists were recently authorized to perform psychotherapy. Purpose. The purpose of this study was to explore the psychotherapy practice, training, and support needs of Ontario occupational therapists. Method. An online survey was sent to occupational therapists who had clients with mental health or chronic pain issues, asking about their expertise and support needs in relation to nine psychotherapy approaches. Findings. Of the 331 therapists who responded, there were variations in the nature and frequency of psychotherapy practice. Experienced therapists in outpatient settings were more likely to practice psychotherapy, and cognitive-behaviour therapy, motivational interviewing, and mindfulness were the most common approaches. Supervision and training varied, with many therapists interested in occupational therapy–specific training. Implications. Recommendations for a framework of support include education about the nature of psychotherapy, training and supervision guidelines, and advocacy for occupational therapy and psychotherapy.
Steering in a Random Forest
Authors: McDonald Anthony D. , Lee John D. , Schwarz Chris , Brown Timothy L. 
Published: December 2013

Objective: The aim of this study was to design and evaluate an algorithm for detecting drowsiness-related lane departures by applying a random forest classifier to steering wheel angle data. Background: Although algorithms exist to detect and mitigate driver drowsiness, the high rate of false alarms and missed detection of drowsiness represent persistent challenges. Current algorithms use a variety of data sources, definitions of drowsiness, and machine learning approaches to detect drowsiness. Method: We develop a new approach for detecting drowsiness-related lane departures using steering wheel angle data that employ an ensemble definition of drowsiness and a random forest algorithm. Data collected from 72 participants driving the National Advanced Driving Simulator are used to train and evaluate the model. The model’s performance was assessed relative to a commonly used algorithm, percentage eye closure (PERCLOS). Results: The random forest steering algorithm had a higher classification accuracy and area under the receiver operating characteristic curve than PERCLOS and had comparable positive predictive value. The algorithm succeeds at identifying two key scenarios associated with the drowsiness detection task. These two scenarios consist of instances when drivers depart their lane because they fail to modulate their steering behavior according to the demands of the simulated road and instances when drivers correctly modulate their steering behavior according to the demands of the road. Conclusion: The random forest steering algorithm is a promising approach to detect driver drowsiness. The algorithm’s ties to consequences of drowsy driving suggest that it can be easily paired with mitigation systems.
Effects of pulmonary artery perfusion with urinary trypsin inhibitor as a lung protective strategy under hypothermic low-flow cardiopulmonary bypass in an infant piglet model
Authors: Li W , Wu X , Yan F , Liu J , Tang Y , Ma K , Li S 
Published: December 2013

Objective: This study aimed to evaluate the effects of pulmonary artery perfusion with a urinary trypsin inhibitor (UTI) as a lung protective strategy in order to provide an experimental basis for immature lung clinical protective strategies on deep hypothermia with low-flow (DHLF) cardiopulmonary bypass (CPB)-induced pulmonary injury in an infant piglet model. Methods: The piglets (n=15), aged 18.7±0.3 days, weight 4.48±0.21kg, were randomly divided into 3 groups, with 5 piglets in each group: the control group, the pulmonary artery perfusion without UTI group (Group P) and the pulmonary artery perfusion with UTI group (Group U). The levels of the cytokines tumour necrosis factor-α, myeloperoxidase, malondialdehyde and interleukin-10 (TNF-α, MPO, MDA and IL-10) in pulmonary venous serum and lung tissue and the activity of NF-kappa B in lung tissue were measured by enzyme-linked immunosorbent assay (ELISA) and electrophoresis mobility shift assay (EMSA), respectively. Results: After DHLF-CPB, all of the piglets demonstrated a state of lung injury as a deterioration of lung function indices, lung injury scores, pulmonary ultrastructure changes, expression of TNF-α, MPO, MDA and IL-10 and the activities of nuclear factor-kappa B (NF-κB), while pulmonary artery perfusion with UTI significantly ameliorated lung function and histopathological changes, with greatly decreased serum levels of TNF-α and MPO compared to the other two groups. Also, we found an increase in the level of IL-10 in Group U lungs compared with that in Group P lungs, which correlated with a strong inhibition in the activity of NF-κB. Conclusion: Pulmonary artery perfusion with UTI ameliorated the DHLF-induced immature pulmonary injury in the lungs via a reduction of pro-inflammatory cytokine expression and up-regulated levels of IL-10 by inhibiting the activity of NF-κB.
Floating left innominate vein neoplastic thrombus: A rare case of mediastinal extension of follicular thyroid carcinoma
Authors: Franco IF , Gurrado A , Lissidini G , Di Meo G , Pasculli A , Testini M 
Published: December 2013

Objective We report a case of advanced follicular thyroid cancer with innominate vein involvement. To our knowledge, this seems to be the first case treated in emergency surgery, reported in literature. Method A 59-year-old woman with a five-year history of a large and mainly right-sided cervical mass presented with dyspnea, unilateral arm swelling, facial flushing, and venous congestion. An emergency computed tomography scan revealed a thyroid mass extending into the upper mediastinum with displacement and compression of the right jugular vein and carotid artery and apparent adherence to the superior vena cava and left innominate vein. Results An emergency total thyroidectomy was performed by means of a sternotomy. The lower portion of the retrosternal goiter projected directly into the left innominate vein, with tumor floating in its lumen. Removal of the neoplastic thrombus was performed, through an incision in the vein, en bloc with the thyroid mass. Both goiter and thrombus were completely replaced by follicular carcinoma. Conclusions Accurate preoperative assessment through contrast-enhanced computed tomography is strongly suggested in the presence of enlarged thyroid gland extending into the mediastinum whenever angioinvasion is suspected. This could prevent blinded maneuvers such as digital externalization of the thoracic component of the gland, which can be fatal in cases of cervico-mediastinal goiter extending into great cervical or mediastinal veins.
The application of sinusoidal blade-leading edges in a fan-design methodology to improve stall resistance
Authors: Corsini Alessandro , Delibra Giovanni , Sheard Anthony G 
Published: December 2013

Taking inspiration from previous biomimetic studies on the performance of humpback whale flippers, this paper reports a programme of work to design a ‘whale-fan’ that incorporates a sinusoidal leading-edge blade profile that mimics the tubercles on humpback whales flippers. Previous researchers have used two-dimensional cascades of aerofoils to study the effects of a sinusoidal profile on aerofoil lift and drag performance. The research was primarily concerned with elucidating the fluid-flow mechanisms induced by the sinusoidal profile and the impact of those mechanisms on aerofoil performance. The results indicate that a sinusoidal leading-edge profile has improved lift recovery post-stall and, thus, is inherently more aerodynamically resistant to the effect of stall. The reported research focuses on the application of previous research conducted with infinite span cascades of aerofoils to the design and optimisation of a finite span aerofoil. The paper presents the assumptions when developing a three-dimensional aerofoil-design methodology that correlates the sinusoidal profile of the blade-leading edge with the desired vorticity distribution at the trailing edge. The authors apply the developed methodology to the design of a fan blade’s tip region to control separation at the trailing edge. The paper presents numerically derived whale-fan performance characteristics and compares them with both numerically and experimentally derived performance characteristics of the baseline fan.
Magnetization transfer and adiabatic T1ρ MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis
Authors: Mangia Silvia , Carpenter Adam F , Tyan Andy E , Eberly Lynn E , Garwood Michael , Michaeli Shalom 
Published: December 2013

Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients that is “normal appearing” on T1-weighted and T2-weighted magnetic resonance images. Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, we implemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρ rotating frame relaxation methods. Methods: Nine relapsing–remitting MS patients and seven healthy controls were recruited. Relaxation parameters were measured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line. Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MS patients as compared with controls ( p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) was substantially more sensitive than the MT ratio for detecting differences between groups ( p = 0.0006). Adiabatic T1ρ was significantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differences were found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for any relaxation parameter. Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied by significant abnormalities in iron content.