bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanically Consistent Model of the 2018 Christmas Volcano‐Tectonic Event at Etna
Authors: Iozzia A. , Currenti G. , Cayol V. , Bonforte A. , Cannata A. , Froger J. L. 
Published: July 2024

AbstractThe interaction between volcanic activity and flank instability during the Christmas Eve eruption at Mount Etna in 2018 is explored, using a mechanically consistent inverse model fitting high spatial resolution SAR data. Inversions search for fractures that may be curved and can accommodate co‐eval pressure and shear stress changes. Displacements associated with the eruption result from the interaction between two intrusion sources: a buried dyke and a curved sheared intrusion that fed the eruption. Moreover, we identify that the sheared magmatic intrusion induced the observed eastward slip on the Pernicana fault, while the Fiandaca fault was undergoing stress accumulation, which was suddenly released during a M5.0 seismic event. The Fiandaca fault is determined to be listric, rooting beneath the mobile eastern flank of the volcano. This study highlights the role of curved fractures, acting as sheared intrusions or as faults, in volcanoes exhibiting flank instabilities.
Improved Temperature‐Dependent Ice Refractive Index Compilation in the Far‐Infrared Spectrum
Authors: Wang Siheng , Ren Tong , Yang Ping , Saito Masanori , Brindley Helen E. 
Published: July 2024

AbstractA new ice refractive index compilation is reported for a broad spectrum ranging from 0.0443 to 106 μm, focusing on the pronounced temperature‐dependence of ice optical properties in the far‐infrared (far‐IR) segment (15–100 μm). A sensitivity study assuming spherical particles shows that selecting ice refractive indices at 12 temperatures and 215 wavelengths in the far‐IR region gives sufficient accuracy in interpolated refractive indices for developing a new ice crystal optical property database. Furthermore, we demonstrate the differences between the bulk single‐scattering properties computed for hexagonal ice particles with this new compilation compared to a previous iteration at three far‐IR wavelengths where substantial differences are noticed between the two ice refractive index compilations. We suggest that our new ice refractive index data set will improve downstream light‐scattering applications for upcoming far‐IR satellite missions and allow robust modeling of outgoing longwave radiation under ice cloud conditions.
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
Authors: Chaudhry Sana , Beckedorff Felipe , Jasdanwala Shaista Shabbir , Totiger Tulasigeri M. , Affer Maurizio , Lawal Abimbola Eunice , Montoya Skye , Tamiro Francesco , Tonini Olivia , Chirino Alexandra , Adams Andrew , Sondhi Anya K. , Noudali Stephen , Cornista Alyssa Mauri , Nicholls Miah , Afaghani Jumana , Robayo Paola , Bilbao Daniel , Nimer Stephen D. , Rodríguez Jose Antonio , Bhatt Shruti , Wang Eric , Taylor Justin 
Published: July 2024

AbstractSF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) revealed responders were enriched with SF3B1 mutations. Given that XPO1 (Exportin-1) is a nuclear exporter responsible for the export of proteins and multiple RNA species, this led to the hypothesis that SF3B1-mutant cells are sensitive to XPO1 inhibition, potentially due to altered splicing. Subsequent RNA sequencing after XPO1 inhibition in SF3B1 wildtype and mutant cells showed increased nuclear retention of RNA transcripts and increased alternative splicing in the SF3B1 mutant cells particularly of genes that impact apoptotic pathways. To identify novel drug combinations that synergize with XPO1 inhibition, a forward genetic screen was performed with eltanexor treatment implicating anti-apoptotic targets BCL2 and BCLXL, which were validated by functional testing in vitro and in vivo. These targets were tested in vivo using Sf3b1K700E conditional knock-in mice, which showed that the combination of eltanexor and venetoclax (BCL2 inhibitor) had a preferential sensitivity for SF3B1 mutant cells without excessive toxicity. In this study, we unveil the mechanisms underlying sensitization to XPO1 inhibition in SF3B1-mutant MDS and preclinically rationalize the combination of eltanexor and venetoclax for high-risk MDS.
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Authors: Chen Zhan-Li , Xie Chen , Zeng Wei , Huang Rui-Qi , Yang Jin-E , Liu Jin-Yu , Chen Ya-Jing , Zhuang Shi-Mei 
Published: July 2024

AbstractMitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasome-mediated protein degradation is crucial for M-phase. Bortezomib (BTZ), which inhibits the 20S catalytic particle of proteasome, is approved to treat multiple myeloma and mantle cell lymphoma, but not solid tumors due to primary resistance. To date, whether and how proteasome inhibitor affected the fates of cells in M-phase remains unexplored. Here, we show that BTZ treatment, or silencing of PSMC5, a subunit of 19S regulatory particle of proteasome, causes G2- and M-phase arrest, multi-polar spindle formation, and consequent caspase-3/GSDME-mediated pyroptosis in M-phase (designated as mitotic pyroptosis). Further investigations reveal that inhibitor of WEE1/PKMYT1 (PD0166285), but not inhibitor of ATR, CHK1 or CHK2, abrogates the BTZ-induced G2-phase arrest, thus exacerbates the BTZ-induced mitotic arrest and pyroptosis. Combined BTZ and PD0166285 treatment (named BP-Combo) selectively kills various types of solid tumor cells, and significantly lessens the IC50 of both BTZ and PD0166285 compared to BTZ or PD0166285 monotreatment. Studies using various mouse models show that BP-Combo has much stronger inhibition on tumor growth and metastasis than BTZ or PD0166285 monotreatment, and no obvious toxicity is observed in BP-Combo-treated mice. These findings disclose the effect of proteasome inhibitors in inducing pyroptosis in M-phase, characterize pyroptosis as a new death form of mitotic catastrophe, and identify dual inhibition of proteasome and WEE family kinases as a promising anti-cancer strategy to selectively kill solid tumor cells.
PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Authors: Kamakura Takeshi , Kameda Kazuaki , Manabe Masahiko , Torii Kan , Sugiura Yuki , Ito Seiko , Nakayama Shunya , Shimizu Takanobu , Nagashima Etsuko , Kamiya Kosuke , Oka Masahiro , Tanaka Masafumi , Otsuka Motoyuki , Ohtsuka Masato , Kotani Ai 
Published: July 2024

AbstractSome RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions, and biological significance of RNA degradation in apoptosis remain elusive. Y RNAs are non-coding RNAs widely conserved from bacteria to mammals, and are major components of Ro ribonucleoprotein (RNP) complexes which contain the 60 kDa Ro protein (SS-A) and the 50 kDa La protein (SS-B). The autoantigenic Ro and La proteins were identified by autoantibodies present in the sera from patients with Systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SjS). We previously identified novel, functional small RNAs named AGO-taxis small RNAs (ASRs) that are specifically bound to Argonaute protein 1 (AGO1), which are processed from Y RNAs. Cell-free analysis combined with fractionation methods revealed that the apoptosis-specific biogenesis of ASRs or cleavage of Y RNA was induced by truncation of polypyrimidine tract-binding protein 1 (PTBP1), which is an endoribonuclease inhibitor of Y RNAs by caspase 3. Caspase 3-resistant PTBP1 mutant protected cleavage of Y RNAs in apoptosis induced by staurosporine. Furthermore, caspase 3-resistant PTBP1 mutant knock-in mice showed elevated cytokines, dysregulation of the germinal center formation compared to the wild-type mice at LPS stimulation, and high positivity of antinuclear antibody. Those results suggest that cleavage of Y RNAs or biogenesis of ASR during apoptosis has critical biological functions and their deregulation result in immune dysregulation and the formation of autoantibody, possibly leading to the development of autoimmune diseases.
Universal hydrogel adhesives with robust chain entanglement for bridging soft electronic materials
Authors: Jo Yejin , Lee Yurim , Heo Jeong Hyun , Son Yeonzu , Kim Tae Young , Park Kijun , Kim Soye , Kim Seo Jung , Jin Yoonhee , Park Seongjun , Seo Jungmok 
Published: July 2024

AbstractEnsuring stable integration of diverse soft electronic components for reliable operation under dynamic conditions is crucial. However, integrating soft electronics, comprising various materials like polymers, metals, and hydrogels, poses challenges due to their different mechanical and chemical properties. This study introduces a dried-hydrogel adhesive made of poly(vinyl alcohol) and tannic acid multilayers (d-HAPT), which integrates soft electronic materials through moisture-derived chain entanglement. d-HAPT is a thin (~1 µm) and highly transparent (over 85% transmittance in the visible light region) adhesive, showing robust bonding (up to 3.6 MPa) within a short time (<1 min). d-HAPT demonstrates practical application in wearable devices, including a hydrogel touch panel and strain sensors. Additionally, the potential of d-HAPT for use in implantable electronics is demonstrated through in vivo neuromodulation and electrocardiographic recording experiments while confirming its biocompatibility both in vitro and in vivo. It is expected that d-HAPT will provide a reliable platform for integrating soft electronic applications.
Molecular weight insight into critical component contributing to reverse osmosis membrane fouling in wastewater reclamation
Authors: Bai Yuan , Wu Yinhu , Zhang Ziwei , Mao Yu , Wang Ruining , Tong Xin , Xue Song , Wang Haobin , Hu Hongying 
Published: July 2024

AbstractMolecular weight (MW) of organics was one of the important factors influencing membrane fouling propensity. This study identified critical foulants of reverse osmosis (RO) membranes in reclaimed water by MW fractionation. MW > 10 kDa component was identified as the critical fouling contributor (CFC) in secondary effluent (SE), which accounted for only 13 ± 5% of dissolved organic carbon (DOC) but contributed to 86 ± 11% of flux decline. Throughout 12-month monitoring, SE and MW > 10 kDa component showed a similar fouling variation tendency: apparently higher fouling potential in winter and lower in summer, while MW < 10 kDa component presented minor fouling changes. Morphology of membrane fouled by CFC characterized a smooth and thick foulant layer on membrane surface. CFC was mainly composed of proteins and polysaccharides, and a protein-polysaccharide-protein “sandwich” fouling layer structure was preferentially formed on membrane surface. extended Derjaguin–Landau-Verwey–Overbeek (xDLVO) analysis demonstrated that strong attractive interactions between CFC and membrane surface dominated the fouling process. Furthermore, computational fluid dynamics (CFD) simulation revealed strong filtration resistance of CFC, confirming its significant fouling potential. Dual effects including attractive interactions and advantageous ridge-and-valley surface appearance accounted for the significant fouling propensity of MW > 10 kDa component and glean valuable insights into RO fouling mechanisms of reclaimed water in practical application.
Contributions of core, mantle and climatological processes to Earth’s polar motion
Authors: Kiani Shahvandi Mostafa , Adhikari Surendra , Dumberry Mathieu , Modiri Sadegh , Heinkelmann Robert , Schuh Harald , Mishra Siddhartha , Soja Benedikt 
Published: July 2024

AbstractEarth’s spin axis slowly moves relative to the crust over time. A 120-year-long record of this polar motion from astronomical and more modern geodetic measurements displays interannual and multidecadal fluctuations of 20 to 40 milliarcseconds superimposed on a secular trend of about 3 milliarcseconds per year. Earth’s polar motion is thought to be driven by various surface and interior processes, but how these processes operate and interact to produce the observed signal remains enigmatic. Here we show that predictions made by an ensemble of physics-informed neural networks trained on measurements to capture geophysical processes can explain the main features of the observed polar motion. We find that glacial isostatic adjustment and mantle convection primarily account for the secular trend. Mass redistribution on the Earth’s surface—for example, ice melting and global changes in water storage—yields a relatively weak trend but explains about 90% of the interannual and multidecadal variations. We also find that core processes contribute to both the secular trend and fluctuations in polar motion, either due to variations in torque at the core–mantle boundary or dynamical feedback of the core in response to surface mass changes. Our findings provide constraints on core–mantle interactions for which observations are rare and global ice mass balance over the past century and suggest feedback operating between climate-related surface processes and core dynamics.
A database of high-pressure crystal structures from hydrogen to lanthanum
Authors: Giannessi Federico , Di Cataldo Simone , Saha Santanu , Boeri Lilia 
Published: July 2024

AbstractThis paper introduces the HEX (High-pressure Elemental Xstals) database, a complete database of the ground-state crystal structures of the first 57 elements of the periodic table, from H to La, at 0, 100, 200 and 300 GPa. HEX aims to provide a unified reference for high-pressure research, by compiling all available experimental information on elements at high pressure, and complementing it with the results of accurate evolutionary crystal structure prediction runs based on Density Functional Theory. Besides offering a much-needed reference, our work also serves as a benchmark of the accuracy of current ab-initio methods for crystal structure prediction. We find that, in 98% of the cases in which experimental information is available, ab-initio crystal structure prediction yields structures which either coincide or are degenerate in enthalpy to within 300 K with experimental ones. The main manuscript contains synthetic tables and figures, while the Crystallographic Information File (cif) for all structures can be downloaded from the related figshare online repository.
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
Authors: Fernandez Maria Victoria , Liu Menghan , Beric Aleksandra , Johnson Matt , Cetin Arda , Patel Maulik , Budde John , Kohlfeld Pat , Bergmann Kristy , Lowery Joseph , Flynn Allison , Brock William , Sanchez Montejo Brenda , Gentsch Jen , Sykora Nicholas , Norton Joanne , Gentsch Jen , Valdez Olga , Gorijala Priyanka , Sanford Jessie , Sun Yichen , Wang Ciyang , Western Dan , Timsina Jigyasha , Mangetti Goncalves Tassia , Do Anh N. , Sung Yun Ju , Zhao Guoyan , Morris John C. , Moulder Krista , Holtzman David M. , Bateman Randall J. , Karch Celeste , Hassenstab Jason , Xiong Chengjie , Schindler Suzanne E. , Balls-Berry Joyce , Benzinger Tammie L. S. , Perrin Richard J. , Denny Andrea , Snider B. Joy , Stark Susan L. , Ibanez Laura , Cruchaga Carlos 
Published: July 2024

AbstractThe Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, and peripheral blood mononuclear cells. The GHTO has performed deep molecular profiling (genomic, transcriptomic, epigenomic, proteomic, and metabolomic) from large number of brain (n = 2,117), CSF (n = 2,012) and blood/plasma (n = 8,265) samples with the goal of identifying novel risk and protective variants, identify novel molecular biomarkers and causal and druggable targets. Overall, the resources available at GHTO support the increase of our understanding of Alzheimer Disease.
Chromosome-level Genome Assembly of Theretra japonica (Lepidoptera: Sphingidae)
Authors: Yan Ming , Su Bao-Shan , Huang Yi-Xin , Xu Zhen-Bang , Jiang Zhuo-Heng , Wang Xu 
Published: July 2024

AbstractTheretra japonica is an important pollinator and agricultural pest in the family Sphingidae with a wide range of host plants. High-quality genomic resources facilitate investigations into behavioral ecology, morphological and physiological adaptations, and the evolution of genomic architecture. However, chromosome-level genome of T. japonica is still lacking. Here we sequenced and assembled the high-quality genome of T. japonica by combining PacBio long reads, Illumina short reads, and Hi-C data. The genome was contained in 95 scaffolds with an accumulated length of 409.55 Mb (BUSCO calculated a genome completeness of 99.2%). The 29 pseudochromosomes had a combined length of 403.77 Mb, with a mapping rate of 98.59%. The genomic characterisation of T. japonica will contribute to further studies for Sphingidae and Lepidoptera.
Small non-coding RNA transcriptomic profiling in adult and fetal human brain
Authors: Smal Marharyta , Memoli Domenico , Alexandrova Elena , Di Rosa Domenico , D’Agostino Ylenia , Russo Fabio , Giurato Giorgio , Nassa Giovanni , Tarallo Roberta , Weisz Alessandro , Rizzo Francesca 
Published: July 2024

AbstractSmall non-coding RNAs (sncRNAs) make up ~1% of the transcriptome; nevertheless, they play significant roles in regulating cellular processes. Given the complexity of the central nervous system, sncRNAs likely hold particular importance in the human brain. In this study, we provide sncRNA transcriptomic profiles in a range of adult and prenatal brain regions, with a focus on piRNAs, due to their underexplored expression in somatic cells and tissue-specific nature. Using the WIND workflow, which combines two detection methods, we found 1333 (731 miRNAs, 249 piRNAs, 285 snoRNAs, and 68 other sncRNAs) and 1445 unique sncRNAs (770 miRNAs, 307 piRNAs, 289 snoRNAs, and 79 other sncRNAs) in developing and adult brains, respectively. Significant variations were found upon comparison of fetal and adult brain groups, with 82 miRNAs, 17 piRNAs, and 70 snoRNAs enriched in fetal brains and 22 miRNAs, 11 piRNAs in adult brains. This dataset represents a valuable resource for exploring the sncRNA roles in brain function, their involvement in neurological diseases, and the molecular mechanisms behind brain region interactions.
Choline consumption reduces CVD risk via body composition modification
Authors: Wang Haomiao , Lin Jinxin , Fan Shitao , Zhang Xuyang , Zhou Tengyuan , Luo Ran , Zhang Chao , Zhang Shuixian , Yang Qingwu , Hu Rong 
Published: July 2024

AbstractDespite extensive research on the relationship between choline and cardiovascular disease (CVD), conflicting findings have been reported. We aim to investigate the relationship between choline and CVD. Our analysis screened a retrospective cohort study of 14,663 participants from the National Health and Nutrition Examination Survey conducted between 2013 and 2018. Propensity score matching and restricted cubic splines was used to access the association between choline intake and the risk of CVD. A two-sample Mendelian randomization (MR) analysis was conducted to examine the potential causality. Additionally, sets of single cell RNA-sequencing data were extracted and analyzed, in order to explore the role of choline metabolism pathway in the progression and severity of the CVD and the underlying potential mechanisms involved. The adjusted odds ratios and 95% confidence intervals for stroke were 0.72 (0.53–0.98; p = 0.035) for quartile 3 and 0.54 (0.39–0.75; p < 0.001) for quartile 4. A stratified analysis revealed that the relationship between choline intake and stroke varied among different body mass index and waist circumference groups. The results of MR analysis showed that choline and phosphatidylcholine had a predominantly negative causal effect on fat percentage, fat mass, and fat-free mass, while glycine had opposite effects. Results from bioinformatics analysis revealed that alterations in the choline metabolism pathway following stroke may be associated with the prognosis. Our study indicated that the consumption of an appropriate quantity of choline in the diet may help to protect against CVD and the effect may be choline-mediated, resulting in a healthier body composition. Furthermore, the regulation of the choline metabolism pathway following stroke may be a promising therapeutic target.
Microwave-assisted synthesis of ZnS@CuInxSy for photocatalytic degradation of coloured and non-coloured pollutants
Authors: Rahman Ashmalina , Khan Fazlurrahman , Jennings James Robert , Kim Young-Mog , Khan Mohammad Mansoob 
Published: July 2024

AbstractCopper indium sulfide (CuInS2) exhibits strong visible light absorption and thus has the potential for good photocatalytic activity; however, rapid charge recombination limits its practical usage. An intriguing strategy to overcome this issue is to couple CuInS2 with another semiconductor to form a heterojunction, which can improve the charge carrier separation and, hence, enhance the photocatalytic activity. In this study, photocatalysts comprising CuInS2 with a secondary CuS phase (termed CuInxSy) and CuInxSy loaded with ZnS (termed ZnS@CuInxSy) were synthesized via a microwave-assisted method. Structural and morphological characterization revealed that the ZnS@CuInxSy photocatalyst comprised tetragonal CuInS2 containing a secondary phase of hexagonal CuS, coupled with hexagonal ZnS. The effective band gap energy of CuInxSy was widened from 2.23 to 2.71 as the ZnS loading increased from 0 to 30%. The coupling of CuInxSy with ZnS leads to long-lived charge carriers and efficient visible-light harvesting properties, which in turn lead to a remarkably high activity for the photocatalytic degradation of brilliant green (95.6% in 5 h) and conversion of 4-nitrophenol to 4-nitrophenolate ions (95.4% in 5 h). The active species involved in these photocatalytic processes were evaluated using suitable trapping agents. Based on the obtained results, photocatalytic mechanisms are proposed that emphasize the importance of h+, O2•–, and OH− in photocatalytic processes using ZnS@CuInxSy.