bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Coincident Metopic and Unilateral Lambdoid Craniosynostosis, a Rare Entity
Authors: Daly Gwendolyn E. , Ferry Andrew M. , Howell Lori K. , Selden Nathan R. , Wolfswinkel Erik M. 
Published: August 2024

Introduction: Multi-suture craniosynostosis is rare and comprises only 3% to 7% of all craniosynostosis cases. Depending on the sutures involved, there are multiple operative approaches for this disease. In this report, we describe the staged surgical management of a patient who presented with metopic and unilateral lambdoid synostosis with initial posterior cranial vault remodeling followed by fronto-orbital advancement (FOA). Methods: At our institution, case reports detailing a single patient are not considered human research by the Institutional Review Board and official approval was not sought. Written consent for inclusion of patient information and images was obtained from the patient’s legally authorized representative. Results: A male patient was treated for metopic and right unilateral lambdoid synostosis. Physical examination was notable for trigonocephaly, right sided posterior plagiocephaly, right mastoid bulging, and contralateral parietal bossing. Treatment of his synostotic deformities was delayed and treated in stages. This was achieved with initial posterior vault expansion, to treat his lambdoid synostosis, via a modification to the classic switch cranioplasty at 5 months of age. The patient subsequently underwent fronto-orbital advancement for correction of metopic synostosis at 10 months of age. The posterior cranial vault remodeling procedure permitted sufficient cranial vault expansion to delay fronto-orbital advancement until 10 months of age. Of note, excellent bone fill and union were observed of the posterior bone grafts at the time of scalp flap elevation during this second procedure. His most recent follow up appointment at 11 months status post FOA demonstrated continued deformational correction as well as good bone fill and wound healing. Conclusions: Multi-suture craniosynostosis is rare with only a single other report in the literature discussing concurrent metopic and unilateral lambdoid synostosis. A multi-stage approach is the most commonly employed technique and must be tailored to each patients’ unique presentation.
Status and determinants of healthcare supply chain practices in public health facilities, Northwest Ethiopia: Mixed-method study
Authors: Tefera Bereket Bahiru , Anbessa Gizachew Tilahun 
Published: August 2024

Objectives: This study sought to assess the current state of healthcare supply chain practices and discern the influencing factors from the perspective of healthcare professionals in the West Gojjam Zone, Ethiopia. Methodology: This research employed a cross-sectional study design, complemented by qualitative study. Data gathering encompassed self-administered surveys and in-depth face-to-face interviews conducted between 30 April and 30 June 2020. Epi-Data facilitated data entry, while SPSS version 20 conducted subsequent analysis. Multiple linear regression was executed, deeming variables with a p-value less than 0.05 as indicative of a significant association. Thematic analysis was applied to analyze the qualitative data. Result: A total of 425 questionnaires were disseminated, with 413 (97.2%) effectively completed and returned. Procurement, after-procurement service, and monitoring and evaluation emerged as areas with suboptimal performance, registering mean values of 2.85, 2.24, and 1.86, respectively. In contrast, storage practices demonstrated relatively superior performance, with a mean value of 3.34. Multiple linear regression analyses unveiled significant correlations between various practices and factors such as training frequency, proficiency of staff in Integrated Pharmaceutical Logistics System (IPLS), managerial support, and proximity to Pharmaceutical Fund and Supply Agency (PFSA). Moreover, impediments to supply chain practices were identified, encompassing limited medication availability at PFSA, budget constraints, tardy reimbursement by the Health Insurance Agency, and a dearth of technicians adept in medical equipment maintenance. Conclusion: The implementation status of healthcare supply chain practices within public health facilities was discerned to be inadequate, with several impediments hindering their effective execution.
Intracranial aneurysms in sickle cell disease are associated with hemodynamic stress and anemia
Authors: Wang Yan , Garland Jared S. , Fellah Slim , Reis Martin N. , Parsons Matthew S. , Guilliams Kristin P. , Fields Melanie E. , Mirro Amy E. , Lewis Josiah B. , Ying Chunwei , Cohen Rachel A. , Hulbert Monica L. , King Allison A. , Chen Yasheng , Lee Jin-Moo , An Hongyu , Ford Andria L. 
Published: August 2024

Abstract
Although hemodynamic stress plays a key role in aneurysm formation outside of sickle cell disease (SCD), its role is understudied in patients with SCD. We hypothesized that tissue-based markers of hemodynamic stress are associated with aneurysm presence in a prospective SCD cohort. Children and adults with SCD, with and without aneurysms, underwent longitudinal brain magnetic resonance imaging/magnetic resonance angiography (MRA) to assess cerebral blood flow (CBF) and oxygen extraction fraction (OEF). Baseline characteristics were recorded. In the subgroup of adults, stepwise mixed-effect logistic regression examined clinical variables, CBF, and OEF as predictors of aneurysm presence. Cumulative rates of new aneurysm formation were estimated using Kaplan-Meier analyses. Forty-three aneurysms were found in 27 of 155 patients (17%). Most aneurysms were ≤3 mm and in the intracranial internal carotid artery. On univariate analysis, older age (P = .07), lower hemoglobin (P = .002), higher CBF (P = .03), and higher OEF (P = .02) were associated with aneurysm presence. On multivariable analysis, age and CBF remained independently associated with aneurysm presence. Seventy-six patients (49% of enrollment) received follow-up MRAs (median, 3.5 years). No aneurysm grew or ruptured, however, 7 new aneurysms developed in 6 patients. The 3-year cumulative rate of aneurysm formation was 3.5%. In 155 patients with SCD, 17% had intracranial aneurysms. Three-year aneurysm formation rate was 3.5%, although limited by small longitudinal sample size and short follow-up duration. Aneurysm presence was associated with elevated CBF in adults, as a tissue-based marker of cerebral hemodynamic stress. Future studies may examine the predictive role of CBF in aneurysm development in SCD.
How will lung cancer screening and lung nodule management change the diagnostic and surgical lung cancer landscape?
Authors: Hardavella Georgia , Frille Armin , Chalela Roberto , Sreter Katherina B. , Petersen Rene H. , Novoa Nuria , de Koning Harry J. 
Published: August 2024

Introduction:
Implementation of lung cancer screening, with its subsequent findings, is anticipated to change the current diagnostic and surgical lung cancer landscape. This review aimed to identify and present the most updated expert opinion and discuss relevant evidence regarding the impact of lung cancer screening and lung nodule management on the diagnostic and surgical landscape of lung cancer, as well as summarise points for clinical practice.

Methods:
This article is based on relevant lectures and talks delivered during the European Society of Thoracic Surgeons–European Respiratory Society Collaborative Course on Thoracic Oncology (February 2023). Original lectures and talks and their relevant references were included. An additional literature search was conducted and peer-reviewed studies in English (December 2022 to June 2023) from the PubMed/Medline databases were evaluated with regards to immediate affinity of the published papers to the original talks presented at the course. An updated literature search was conducted (June 2023 to December 2023) to ensure that updated literature is included within this article.

Results:
Lung cancer screening suspicious findings are expected to increase the number of diagnostic investigations required therefore impacting on current capacity and resources. Healthcare systems already face a shortage of imaging and diagnostic slots and they are also challenged by the shortage of interventional radiologists. Thoracic surgery will be impacted by the wider lung cancer screening implementation with increased volume and earlier stages of lung cancer. Nonsuspicious findings reported at lung cancer screening will need attention and subsequent referrals where required to ensure participants are appropriately diagnosed and managed and that they are not lost within healthcare systems.

Conclusions:
Implementation of lung cancer screening requires appropriate mapping of existing resources and infrastructure to ensure a tailored restructuring strategy to ensure that healthcare systems can meet the new needs.
The awareness of enhanced recovery after surgery (ERAS) cesarean delivery guidelines among anesthesiology and reanimation assistants in Turkey; a questionnaire study
Authors: Dedebagı Zeliha , Özden Eyyüp Sabri , Özcan Mustafa Soner , Solmaz Filiz Alkaya , Kırdemir Pakize 
Published: August 2024

Abstract
Background
To reduce maternal-fetal morbidity and mortality, it is becoming increasingly important for anesthetists to understand and implement enhanced recovery after surgery (ERAS) cesarean delivery guidelines. Our aim was to reveal the knowledge of anesthesia assistants in Turkey about ERAS during cesarean delivery and to increase their awareness of ERAS.

Methods
This descriptive study was conducted in the city of Isparta, Turkey in 2023. The survey, which was approved by the ethics committee, was distributed to participants across Turkey via e-mail and online messages. The survey comprises of a total of 42 questions evaluating perioperative ERAS recommendations.

Results
Of the 404 participants in our survey, 59.9% were associated with university hospitals and 65.8% had completed three or more years of education. A total of 87.9% of the participants were familiar with ERAS; however, only 42.8% had received ERAS training. Although 93.8% of the participants’ institutions performed a cesarean delivery, ERAS recommendations were only implemented at a rate of 48%. This may be due to the absence of an ERAS team, which was identified in our survey at a high rate of 66.6%.

Conclusion
Awareness about ERAS was high among the participants, but the implementation rates of some recommendations were low. The reason for this may be the inability to form a multidisciplinary team and inadequate training of participants. For this purpose, we recommend the formation of a multidisciplinary team for ERAS protocol implementation and increased participant training opportunities.
A systematic review assessing the association of inflammatory markers with kidney dysfunction in people living with HIV on highly active antiretroviral therapy
Authors: Choshi Joel , Hanser Sidney , Mabhida Sihle E. , Mokoena Haskly , Moetlediwa Marakiya T. , Muvhulawa Ndivhuwo , Sekgala Machoene D , Nkambule Bongani B. , Mchiza Zandile J.R. , Ndwandwe Duduzile , Nqebelele Unati , Kengne André P. , Dludla Phiwayinkosi V. 
Published: August 2024

AbstractMonitoring chronic diseases, particularly kidney disorders, in people living with HIV (PLWH) is of paramount importance. Here, a systematic search was conducted across electronic search engine and databases like PubMed, Scopus, and Google Scholar, from date of inception until December 2023, to identify pertinent studies reporting on any association between inflammation and kidney function in PLWH. Only six clinical studies in peer-reviewed journals met the inclusion criteria, involving 1467 participants aged 37 to 51, with approximately 17% being females. The report emphasizes the potential impact of highly active antiretroviral therapy (HAART) on kidney function in PLWH, highlighting the significance of monitoring inflammation markers as indicators of kidney function, even when HAART is effective. Acknowledging study limitations, particularly the scarcity of relevant research, the findings highlight a need for more research to inform on clinical guidance to optimize HIV management, particularly regarding kidney health and HAART regimens. Although very limited studies were evaluated, the study lays an important foundation for future research to uncover the complex relationship between HAART, inflammation markers, and kidney health in PLWH.
Evaluating tuberculosis knowledge and awareness of effective control practices among health care workers in primary- and secondary-level medical institutions in Beijing, China
Authors: Zhang Lijie , Ma Xiaoge , Liu Menghan , Wu Sihui , Li Zhili , Liu Yuhong 
Published: August 2024

Abstract
Objective
Inadequate tuberculosis (TB) knowledge and awareness of proper TB control practices among health care workers (HCWs) may increase the risk of nosocomial TB transmission. This study aimed to assess HCWs’ TB-related knowledge and control practices to guide the development of more effective targeted TB health education and training programs.

Methods
In January 2023 a cross-sectional survey was administered to 323 HCWs employed by five primary health care centers and three secondary comprehensive medical institutions in Beijing, China. Survey data were collected using a standard questionnaire.

Results
Analysis of survey responses revealed TB knowledge and practices awareness rates of 60.4% and 90.6%, respectively. The overall average awareness rate across all 19 TB knowledge- and practice-related questions was 70.0%. Intermediate- and senior-level HCW’s average TB knowledge score was respectively 2.225 and 8.175 times higher than that of primary-level HCWs, while the average TB knowledge score of HCWs in secondary comprehensive medical institutions was 3.052 times higher than that of HCWs in primary health care centers. Higher average TB knowledge score correlated with higher-level professional titles and higher level work units, but higher average TB control practices score correlated with employment at primary health care center rather than secondary comprehensive medical institution. Notably, 13.6% of HCWs had not received TB training during the past three years, while 86.1% expressed willingness to undergo online TB training.

Conclusion
These findings highlight inadequate TB knowledge and awareness of proper TB control practices among HCWs in primary health care centers and secondary comprehensive medical institutions in Beijing, underscoring the urgent need for targeted educational and training initiatives to improve TB awareness and control efforts.
Fibrin-konjac glucomannan-black phosphorus hydrogel scaffolds loaded with nasal ectodermal mesenchymal stem cells accelerated alveolar bone regeneration
Authors: Zou Yin , Mei Xue , Wang Xinhe , Zhang Xuan , Wang Xun , Xiang Wen , Lu Naiyan 
Published: August 2024

AbstractBackgroundEffective treatments for the alveolar bone defect remain a major concern in dental therapy. The objectives of this study were to develop a fibrin and konjac glucomannan (KGM) composite hydrogel as scaffolds for the osteogenesis of nasal mucosa-derived ectodermal mesenchymal stem cells (EMSCs) for the regeneration of alveolar bone defect, and to investigate the osteogenesis-accelerating effects of black phosphorus nanoparticles (BPNs) embedded in the hydrogels.MethodsPrimary EMSCs were isolated from rat nasal mucosa and used for the alveolar bone recovery. Fibrin and KGM were prepared in different ratios for osteomimetic hydrogel scaffolds, and the optimal ratio was determined by mechanical properties and biocompatibility analysis. Then, the optimal hydrogels were integrated with BPNs to obtain BPNs/fibrin-KGM hydrogels, and the effects on osteogenic EMSCs in vitro were evaluated. To explore the osteogenesis-enhancing effects of hydrogels in vivo, the BPNs/fibrin-KGM scaffolds combined with EMSCs were implanted to a rat model of alveolar bone defect. Micro-computed tomography (CT), histological examination, real-time quantitative polymerase chain reaction (RT-qPCR) and western blot were conducted to evaluate the bone morphology and expression of osteogenesis-related genes of the bone regeneration.ResultsThe addition of KGM improved the mechanical properties and biodegradation characteristics of the fibrin hydrogels. In vitro, the BPNs-containing compound hydrogel was proved to be biocompatible and capable of enhancing the osteogenesis of EMSCs by upregulating the mineralization and the activity of alkaline phosphatase. In vivo, the micro-CT analysis and histological evaluation demonstrated that rats implanted EMSCs-BPNs/fibrin-KGM hydrogels exhibited the best bone reconstruction. And compared to the model group, the expression of osteogenesis genes including osteopontin (Opn,p < 0.0001), osteocalcin (Ocn,p < 0.0001), type collagen (Col ,p < 0.0001), bone morphogenetic protein-2 (Bmp2,p < 0.0001), Smad1 (p = 0.0006), and runt-related transcription factor 2 (Runx2,p < 0.0001) were all significantly upregulated.ConclusionsEMSCs/BPNs-containing fibrin-KGM hydrogels accelerated the recovery of the alveolar bone defect in rats by effectively up-regulating the expression of osteogenesis-related genes, promoting the formation and mineralisation of bone matrix.
Implementation of integrated care for type 2 diabetes Mellitus and Periodontitis in Germany: study protocol for a practice-based and cluster-randomized trial
Authors: Hennrich Patrick , Queder Annika , Altiner Attila , Awounvo Sinclair , Dyczmons Jan , Eigendorf Julian , Erdmann Stella , Grobe Thomas , Gutscher Andreas , Herzig Nicole , Jepsen Søren , Kairies-Schwarz Nadja , Kalmus Olivier , Kliemannel Fabian , Santos Sara , Vanella Patrizio , Wensing Michel , Wilm Stefan , Listl Stefan 
Published: August 2024

Abstract
Background
Type 2 Diabetes mellitus (T2DM) and periodontitis share common risk factors and influence one another. However, primary care and oral health care continue to operate separate from each other and fail to synchronize care for patients with T2DM and periodontitis. The purpose of this practice-based trial is to evaluate the implementation of a new integrated care pathway for patients with T2DM and periodontitis. The new approach integrates a screening for T2DM risk in dental care settings in patients with periodontitis, a screening for periodontitis risk in primary care settings in patients with T2DM, and mutual referrals between dentists and primary care physicians.

Methods
Two practice-based studies will be carried out in parallel: (i) In dental care settings: a practice-based, multi-centric, cluster-randomized, controlled trial with a control and an intervention group; (ii) in primary care settings: a practice-based, multi-centric, non-randomized, controlled trial with a synthetic control group calculated from claims data. Following a two-step recruitment approach, 166 dentists and 248 general practitioners will be recruited, who themselves will recruit a total of 3808 patients in their practices. Patient data will be collected at baseline, 12 months, and 24 months after study enrollment. The evaluation comprises: (i) impact evaluation, using a hierarchical linear mixed model; (ii) process evaluation, based on surveys alongside the trials; (iii) economic evaluation. In addition, a Discrete-Choice-Experiment will identify provider’s payment preferences for the new care approach.

Discussion
Upon successful implementation, the intervention will enable health care providers to detect a risk for T2DM and periodontitis in patients at an early stage, thus providing patients an opportunity for timely diagnosis and therapy. Ultimately, this can lead to increased quality of life and reduced health care expenditures. On a methodologic level, the project provides novel insights into a complex intervention on the intersection of general practice and dental care.

Trial registration
The study was prospectively registered at the German Clinical Trials Register (https://drks.de/search/de/trial/DRKS00030587) on 3. July 2023 under ID “DRKS00030587“.
The relationship professional commitment and ethics with patient rights: a cross-sectional descriptive study
Authors: Mohammadnejad Sara , Raiesifar Afsaneh , Karamelahi Zoleikha , Chehreh Razhan 
Published: August 2024

Abstract
Background
Ethical behavior of health workers is an important part of health services. The aim of the present study was to determine the relationship between ethics and professional commitment and its relationship with the level of respect for patient rights in medical students.

Material & methods
A cross-sectional descriptive study was conducted with the participation of nursing, midwifery and emergency medicine students of Ilam University of Medical Sciences. Sampling was done by stratified random method. The data was collected using Demographic, Professional Commitment, Professional ethics and a researcher made questioner on compliance with patient rights questionnaires.

Results
300 students were participated. The results showed that the average score of professional ethics in middle school students is high (64.07 ± 8.01), the average score of professional commitment is also high (64.07 ± 8.01) and the score of respect for patient rights is also high (10.74). ± 83.46) was obtained. The professional ethics score it showed a positive and statistically significant relationship with the patient’s rights compliance score. only professional commitment is related to gender, but the average of all three variables in different age groups and the type of residence (dormitory, private home, etc.) have meaningful statistical difference.

Conclusion
The findings of the study show that the level of ethics and professional commitment and respect for patient rights among nursing, midwifery and emergency medicine students was good. It is hoped that the results of this research will provide a basis for better planning for the development of knowledge and respect for patient rights among students.
Understanding the barriers and facilitators of healthcare services for brain injury and concurrent mental health and substance use issues: a qualitative study
Authors: Grewal Jasleen , Kennedy Cole J. , Mamman Rinni , Biagioni Janelle Breese , Garcia-Barrera Mauricio A. , Schmidt Julia 
Published: August 2024

Abstract
Background
People with acquired brain injury (ABI) may experience concurrent conditions such as, mental health and substance use concerns, that require specialized care. There are services that aim to support people with ABI and these conditions separately; however, little is known about the facilitators and barriers of these services. Therefore, the purpose of this study was to engage stakeholders to investigate the facilitators and barriers of healthcare services for ABI and concurrent issues.

Methods
Semi-structured focus groups were conducted in-person and virtually with people with ABI, caregivers, healthcare professionals, and policy makers during a one-day event in British Columbia, Canada. Manifest content analysis was used with a constructivist perspective to analyze data.

Results
90 participants (including 34 people with ABI) provided insights during 15 simultaneous focus groups. Three categories were identified: (1) complexity of ABI, (2) supports, (3) structure of care. Complexity of ABI outlined the ongoing basic needs after ABI and highlighted the need for public awareness of ABI. Supports outlined healthcare professional and community-based supports. Structure of care described people with ABI needing to meet criteria for support, experiences of navigating through the system and necessity of integrated services.

Conclusions
These findings highlight the facilitators and barriers of healthcare services for ABI and concurrent conditions and provide insights into the changes that may be needed. Doing so can improve the accessibility and quality of ABI healthcare services.