bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children's Sensitivity to Ulterior Motives When Evaluating Prosocial Behavior
Authors: Heyman Gail , Barner David , Heumann Jennifer , Schenck Lauren 
Published: September 2013

AbstractReasoning about ulterior motives was investigated among children ages 6–10 years (total N = 119). In each of two studies, participants were told about children who offered gifts to peers who needed help. Each giver chose to present a gift in either a public setting, which is consistent with having an ulterior motive to enhance one's reputation, or in a private setting, which is not consistent with having an ulterior motive. In each study, the 6‐ to 7‐year olds showed no evidence of understanding that the public givers might have ulterior motives, but the 8‐ to 10‐year olds rated the private givers more favorably. In , the older children were more likely than the younger children to refer to impression management when explaining their judgments of the givers. The younger children who mentioned impression management did so to justify a preference for public givers (e.g., by explaining that public givers are nicer because more of their peers will know that they are nice). Results from suggest that developmental change in children's reasoning about intentions and social outcomes contributes to their understanding of ulterior motives.
Whole-Genome Sequences of Staphylococcus aureus ST398 Strains of Animal Origin
Authors: Hernandez David , van der Mee-Marquet Nathalie , Kluytmans Jan , Donnio Pierre-Yves , Quentin Roland , Corvaglia Anna-Rita , François Patrice 
Published: September 2013

ABSTRACT

Staphylococcus aureus
sequence type 398 (ST398) was originally associated with animal infections. We announce the complete genome sequences of two ST398 methicillin-susceptible
S. aureus
strains from the livestock environment. These genome sequences assist in the characterization of interesting ST398 features relying on host tropism and epidemiological settings
.
Genome Sequences of Three hpAfrica2 Strains of Helicobacter pylori
Authors: Duncan Stacy S. , Bertoli M. Teresita , Kersulyte Dangeruta , Valk Pieter L. , Tamma Sravya , Segal Issy , McClain Mark S. , Cover Timothy L. , Berg Douglas E. 
Published: September 2013

ABSTRACT

We present the genome sequences of three hpAfrica2 strains of
Helicobacter pylori
, which are postulated to have evolved in isolation for many millennia in people of San ethnicity. Although previously considered to be ancestral to
Helicobacter acinonychis
, the hpAfrica2 strains differ markedly from
H. acinonychis
in their gene arrangement. These data provide new insights into
Helicobacter
evolution.
Whole-Genome Shotgun Sequencing of Rhodococcus erythropolis Strain P27, a Highly Radiation-Resistant Actinomycete from Antarctica
Authors: Gouvêa Taketani Rodrigo , Domingues Zucchi Tiago , Soares de Melo Itamar , Mendes Rodrigo 
Published: September 2013

ABSTRACT

Here, we report the draft genome sequence of radiation-resistant
Rhodococcus erythropolis
strain P27, isolated from leaves of
Deschampsia antarctica
Desv. (
Poaceae
) in the Admiralty Bay area, Antarctica.
Genome Sequence of Lactobacillus fermentum Strain MTCC 8711, a Probiotic Bacterium Isolated from Yogurt
Authors: Jayashree Sathyanarayanan , Pooja Sharma , Pushpanathan Muthuirulan , Vishnu Udayakumar , Sankarasubramanian Jagadesan , Rajendhran Jeyaprakash , Gunasekaran Paramasamy 
Published: September 2013

ABSTRACT

Lactobacillus fermentum
strain MTCC 8711 is a lactic acid bacterium isolated from yogurt. Here, we describe the draft genome sequence and annotation of this strain. The 2,566,297-bp-long genome consisted of a single chromosome and seven plasmids. The genome contains 2,609 protein-coding and 74 RNA genes.
Draft Genome Sequence of Exopolysaccharide-Producing Thermophilic Bacterium Brevibacillus thermoruber Strain 423
Authors: Yasar Yildiz Songul , Kambourova Margarita , Arga Kazim Yalcin , Toksoy Oner Ebru 
Published: September 2013

ABSTRACT

Brevibacillus thermoruber
strain 423 is a Gram-positive, spore-forming, aerobic, and thermophilic bacterium that produces mannogalactoglucan exopolysaccharide (EPS). We report the draft genome sequence of
B. thermoruber
423, which will accelerate research on the cellular organization of thermophilic bacteria, as well as the rational design and optimization of EPS production.
Complete Genome Sequence of Staphylococcus aureus 6850, a Highly Cytotoxic and Clinically Virulent Methicillin-Sensitive Strain with Distant Relatedness to Prototype Strains
Authors: Fraunholz Martin , Bernhardt Jörg , Schuldes Jörg , Daniel Rolf , Hecker Michael , Sinha Bhanu 
Published: September 2013

ABSTRACT

Staphylococcus aureus
is a frequent human commensal bacterium and pathogen. Here we report the complete genome sequence of strain 6850 (
spa
type t185; sequence type 50 [ST50]), a highly cytotoxic and clinically virulent methicillin-sensitive strain from a patient with complicated
S. aureus
bacteremia associated with osteomyelitis and septic arthritis.
Protocol for a randomised controlled trial: efficacy of donepezil against psychosis in Parkinson's disease (EDAP)
Authors: Sawada Hideyuki , Oeda Tomoko 
Published: September 2013

IntroductionPsychosis, including hallucinations and delusions, is one of the important non-motor problems in patients with Parkinson's disease (PD) and is possibly associated with cholinergic neuronal degeneration. The EDAP (Efficacy of Donepezil against Psychosis in PD) study will evaluate the efficacy of donepezil, a brain acetylcholine esterase inhibitor, for prevention of psychosis in PD.Methods and analysisPsychosis is assessed every 4 weeks using the Parkinson Psychosis Questionnaire (PPQ) and patients with PD whose PPQ-B score (hallucinations) and PPQ-C score (delusions) have been zero for 8 weeks before enrolment are randomised to two arms: patients receiving donepezil hydrochloride or patients receiving placebo. The patients are then followed for 96 weeks. The primary outcome measure is the time to the event, defined as getting 2 points or more on the PPQ-B score or PPQ-C score, which is assessed using a survival time analysis. The hypothesis being tested is that donepezil prevents psychosis in patients with PD. Efficacy will be tested statistically using the intention-to-treat analysis including a log-rank test or Cox proportional hazard models. Secondary outcomes, such as changes of PPQ scores and Unified Parkinson's Disease Rating Scale scores from baseline will be assessed.Ethics and disseminationEthics approval was received from the Central Review Board of the National Hospital Organization, Tokyo, Japan. The trial was declared and registered to the Pharmaceuticals and Medical Devices Agency(PMDA), Japan (No. 22-4018). All participants will receive a written informed consent that was approved by the Central Review. A completed written informed consent is required to enrol in the study. Severe adverse events will be monitored by investigators and in cases where a severe adverse event was previously unreported, it will be reported to the PMDA.Clinical Trial Registration NumberUMIN000005403.
Physical activity during pregnancy and offspring cardiovascular risk factors: findings from a prospective cohort study
Authors: Millard Louise A C , Lawlor Debbie A , Fraser Abigail , Howe Laura D 
Published: September 2013

ObjectivesThe long-term consequences of maternal physical activity during pregnancy for offspring cardiovascular health are unknown. We examined the association of maternal self-reported physical activity in pregnancy (18 weeks gestation) with offspring cardiovascular risk factors at age 15.DesignProspective cohort study.SettingThe Avon Longitudinal Study of Parents and Children (ALSPAC).Participants4665 maternal-offspring pairs (based on a sample with multiple imputation to deal with missing data) from the ALSPAC, a prospective cohort based in the South West of England with mothers recruited in pregnancy in 1991–1992.Primary and secondary outcome measuresOffspring cardiovascular risk factors at age 15; body mass index (BMI), waist circumference, systolic blood pressure, diastolic blood pressure, glucose, insulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides.ResultsGreater maternal physical activity was associated with lower BMI, waist circumference, glucose and insulin in unadjusted analyses. The magnitude of associations was generally small with wide CIs, and most associations attenuated towards the null after adjusting for confounders. The strongest evidence of association after adjustment for confounders was for glucose, although the 95% CI for this association includes the null; a one SD greater physical activity during pregnancy was associated with a −0.013 mmol/L difference in offspring glucose levels (equivalent to approximately one-third of a SD; 95% CI −0.027 to 0.001 mmol/L).ConclusionsOur results suggest that maternal physical activity in pregnancy, measured at 18 weeks gestation, is unlikely to be an important determinant of later offspring cardiovascular health. There was some suggestion of association with offspring glucose, but given that all other associations (including insulin) were null after adjustment for confounders, this result should be interpreted with caution.
Initial non-participation and loss to follow-up in a Danish youth cohort: implications for relative risk estimates
Authors: Winding Trine N , Andersen Johan H , Labriola Merete , Nohr Ellen A 
Published: September 2013

BackgroundInitial non-participation and loss to follow-up in the Danish youth cohort Vestliv could introduce selection bias of the measured risk estimates.ObjectiveTo investigate the impact of initial non-participation and loss to follow-up on the validity of descriptive measures and selected estimates of relative risk.MethodsOf the 3681 young people defining the source population, 83% answered a questionnaire at baseline in 2004. At follow-up waves in 2007 and 2010, the response rates were 71% and 64%, respectively. Relative ORs (RORs) were used to examine the impact of initial non-participation and loss to follow-up on the association between socioeconomic or personal risk factors at age 14/15 and educational attainment at age 20/21. RORs were calculated as OR (baseline population)/OR (source population) or OR (follow-up population)/OR (baseline population).ResultsThe participants had slightly better school abilities and came more often from homes with two adults, higher income or higher educational level. These differences increased at subsequent follow-ups. The effect of initial non-participation on the ORs was modest with most RORs being close to one. Loss to follow-up led to larger variations in the RORs ranging from 0.77 to 1.62 although for most estimates, the bias was minor. None of the measured RORs were statistically different from one indicating no significant bias.ConclusionsAlthough certain characteristics were related to those who initially chose to participate and especially to those who participated at follow-ups, it did not have any large influence on the relative risk estimates measured in the study.
Contribution of sexual practices (other than anal sex) to bacterial sexually transmitted infection transmission in men who have sex with men: a cross-sectional analysis using electronic health records
Authors: Nash Jessica L , Hocking Jane S , Read Tim R H , Chen Marcus Y , Bradshaw Catriona S , Forcey Dana S , Fairley Christopher K 
Published: September 2013

ObjectiveWe quantified the proportion of cases and risk of primary syphilis (PS), urethral chlamydia (UCT) and urethral gonorrhoea (UGC) attributable to sexual practices other than anal sex.MethodsIn this cross-sectional study, electronic records for men who have sex with men (MSM) who attended the Melbourne Sexual Health Centre between July 2002 (for PS) or January 2006 (for UCT and UGC) and October 2012, inclusive, were examined.ResultsThere were 37 533 eligible consultations; 2374 (6%) of these reported no anal sex. There were 204 PS diagnoses, 673 UCT diagnoses, and 618 UGC diagnoses; 12 (6%), 16 (2%) and 44 (7%) cases, respectively, occurred in consultations where no anal sex was reported in the previous 3 months (PS, UGC) or twelve months (UCT). Among MSM reporting no anal sex, PS was diagnosed in 0.5 cases/100 consultations, UCT was diagnosed in 1.5 cases/100 tests for UCT and UGC was diagnosed in 14 cases/100 tests for UGC. UCT was significantly more common in MSM reporting anal sex (OR 2.18, 95% CI 1.32 to 3.59, p=0.002), but PS (OR 1.07 95% CI 0.6 to 1.93, p=0.82) and UGC (OR 1.28 95% CI 0.92 to 1.79. p=0.14) were not. For MSM reporting anal sex, condom use was protective for all three infections (all p≤0.03).ConclusionsOur findings suggest that UCT uncommonly occurs from sexual practices other than anal sex; however, these practices contribute significantly to PS and UGC. Successful programmes to control PS and UGC will need strategies, such as frequent testing, in addition to promoting condom use.
Connectivity estimation between turbiditic channels and overbank deposits from the modelling of an outcrop analogue (Pab Formation, Maastrichtian, Pakistan)
Authors: Eschard R. , Deschamps R. , Doligez B. , Lerat O. , Langlais V. , Euzen T. 
Published: September 2013

Abstract
The facies associations of the overflow deposits associated with turbidite channels were studied in the outcrops of the Maastrichtian Pab Sandstone, in SW Pakistan. In this area, a basin-floor fan was preserved from the platform to the deep basin setting. In the mid-fan setting, a channel complex crops out in three dimensions, and consists of a dozen channels and their overflow deposits, including levees, crevasse lobes and spill-over lobes. The overbank deposits can be directly in contact with the channel-fill, but, in many cases, matrix-supported debris-flow deposits made lenses close to the channel base. Heterolithic drapes of thin-bedded turbidite deposits were also preserved along the channel margins. A three-dimensional (3D) static model describing the heterogeneity distribution within the turbiditic channel complex was compiled using both stochastic and deterministic approaches in a site where two channels were laterally connected by overbank deposits. Petro-acoustic properties derived from a subsurface database were then assigned to the facies to perform seismic simulations. The synthetic seismic simulations showed that the channel base can easily be misinterpreted compared to the geological model. Dynamic modelling, such as well test and streamline simulations, was also performed using the model to assess the transition between the channel and overbank deposits from a dynamic point of view. As a result of the streamline simulations, the overbank deposits connecting the channel homogenized the pressure regime in the reservoir. However, the sweeping efficiency of water injection can be affected by the heterogeneity distribution along the channel margins. A significant volume of oil could also be by-passed because of the occurrence of early water breakthrough through the spill-over lobes, or because the flow slowed down when it reached the heterogeneity along the channel margin.
Photodynamic Therapy of Murine Mastocytoma Induces Specific Immune Responses against the Cancer/Testis Antigen P1A
Authors: Mroz Pawel , Vatansever Fatma , Muchowicz Angelika , Hamblin Michael R. 
Published: September 2013

AbstractPhotodynamic therapy (PDT) involves the intravenous administration of photosensitizers followed by illumination of the tumor with visible light, leading to local production of reactive oxygen species that cause vascular shutdown and tumor cell death. Antitumor immunity is stimulated after PDT because of the acute inflammatory response that involves activation of the innate immune system, leading to stimulation of adaptive immunity. We carried out PDT using benzoporphyrin derivative and 690-nm light after 15 minutes, in DBA/2 mice bearing either the mastocytoma, P815, which expresses the naturally occurring cancer/testis antigen P1A, or the corresponding tumor P1.204 that lacks P1A expression. Tumor cures, significantly higher survival, and rejection of tumor rechallenge were obtained with P815, which were not seen with P1.204 or seen with P815 growing in nude mice. Both CD4 and CD8 T cells had higher levels of intracellular cytokines when isolated from mice receiving PDT of P815 tumors than P1.204 tumors and CD8 T cells from P815-cured mice recognized the peptide epitope of the P1A antigen (LPYLGWLVF) using pentamer staining. Taken together, these findings show that PDT can induce a potent antigen- and epitope-specific immune response against a naturally occurring mouse tumor antigen. Cancer Res; 73(21); 6462–70. ©2013 AACR.
Targeting Plasminogen Activator Inhibitor-1 Inhibits Angiogenesis and Tumor Growth in a Human Cancer Xenograft Model
Authors: Gomes-Giacoia Evan , Miyake Makito , Goodison Steve , Rosser Charles J. 
Published: September 2013

AbstractCancers of the urinary bladder result in aggressive and highly angiogenic tumors for which standard treatments have only limited success. Patients with advanced disease have a 5-year survival rate of less than 20%, and no new anticancer agent has been successfully introduced into the clinic armamentarium for the treatment of bladder cancer in more than 20 years. Investigations have identified plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, as being highly expressed in several malignancies, including bladder cancer, in which high expression is associated with a poor prognosis. In this study, we evaluated PAI-1 as a potential therapeutic target for bladder cancer. PAI-1 expression was manipulated in a panel of cell lines and functional inhibition was achieved using the small molecule tiplaxtinin. Reduction or inhibition of PAI-1 resulted in the reduction of cellular proliferation, cell adhesion, and colony formation, and the induction of apoptosis and anoikis in vitro. Treatment of T24 xenografts with tiplaxtinin resulted in inhibition of angiogenesis and induction of apoptosis, leading to a significant reduction in tumor growth. Similar results were obtained through evaluation of the human cervical cancer HeLa cell line, showing that PAI-1–mediated effects are not restricted to tumor cells of bladder origin. Collectively, these data show that targeting PAI-1 may be beneficial and support the notion that novel drugs such as tiplaxtinin could be investigated as anticancer agents. Mol Cancer Ther; 12(12); 2697–708. ©2013 AACR.
A Novel Combinatorial Nanotechnology-Based Oral Chemopreventive Regimen Demonstrates Significant Suppression of Pancreatic Cancer Neoplastic Lesions
Authors: Grandhi B. Karthik , Thakkar Arvind , Wang Jeffrey , Prabhu Sunil 
Published: September 2013

Abstract
Pancreatic cancer is a deadly disease killing 37,000 Americans each year. Despite two decades of research on treatment options, the chances of survival are still less than 5% upon diagnosis. Recently, chemopreventive strategies have gained considerable attention as an alternative to treatment. We have previously shown significant in vitro chemopreventive effects with low-dose combinations of aspirin, curcumin, and sulforaphane (ACS) on pancreatic cancer cell lines. Here, we report the results of 24-week chemopreventive study with the oral administration of ACS combinations on the N-nitrosobis (2-oxopropyl) amine (BOP)-treated Syrian golden hamster model to suppress the progression of pancreatic intraepithelial neoplasms (PanIN) using unmodified (free drug) combinations of ACS, and nanoencapsulated (solid lipid nanoparticles; SLN) combinations of aspirin, curcumin, and free sulforaphane. The use of three different doses (low, medium, and high) of unmodified ACS combinations exhibited reduction in tumor incidence by 18%, 50%, and 68.7% respectively; whereas the modified nanoencapsulated ACS regimens reduced tumor incidence by 33%, 67%, and 75%, respectively, at 10 times lower dose compared with the free drug combinations. Similarly, although the unmodified free ACS showed a notable reduction in cell proliferation, the SLN encapsulated ACS regimens showed significant reduction in cell proliferation at 6.3%, 58.6%, and 72.8% as evidenced by proliferating cell nuclear antigen expression. Cell apoptotic indices were also upregulated by 1.5, 2.8, and 3.2 times, respectively, compared with BOP control. These studies provide a proof-of-concept for the use of an oral, low-dose, nanotechnology-based combinatorial regimen for the long-term chemoprevention of pancreatic cancer. Cancer Prev Res; 6(10); 1015–25. ©2013 AACR.
ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry
Authors: Karreth Florian A. , Pandolfi Pier Paolo 
Published: September 2013

Abstract
The cancer transcriptome is characterized by aberrant expression of both protein-coding and noncoding transcripts. Similar to mRNAs, a significant portion of the noncoding transcriptome, including long noncoding RNAs and pseudogenes, harbors microRNA (miRNA)-response elements (MRE). The recent discovery of competitive endogenous RNAs (ceRNA), natural decoys that compete for a common pool of miRNAs, provides a framework to systematically functionalize MRE-harboring noncoding RNAs and integrate them with the protein-coding RNA dimension in complex ceRNA networks. Functional interactions in ceRNA networks aid in coordinating a number of biologic processes and, when perturbed, contribute to disease pathogenesis. In this review, we discuss recent discoveries that implicate natural miRNA decoys in the development of cancer.
Significance: Cross-talk between ceRNAs through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such as cancer. As cross-talk can be predicted on the basis of the overlap of miRNA-binding sites, we are now one step closer to a complete functionalization of the human transcriptome, especially the noncoding space. Cancer Discov; 3(10); 1113–21. ©2013 AACR.
Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL
Authors: Aspord Caroline , Leccia Marie-Therese , Charles Julie , Plumas Joel 
Published: September 2013

Abstract
Even though melanoma is considered to be one of the most immunogenic solid tumors, handling its development remains a challenge. The basis for such escape from antitumor immune control has not yet been documented. Plasmacytoid dendritic cells (pDC) are emerging as crucial but still enigmatic cells in cancer. In melanoma, the function of tumor-infiltrating pDCs remains poorly explored. We investigated the pathophysiologic role of pDCs in melanoma, both ex vivo from a large cohort of melanoma patients and in vivo in melanoma-bearing humanized mice. pDCs were found in high proportions in cutaneous melanoma and tumor-draining lymph nodes, yet associated with poor clinical outcome. We showed that pDCs migrating to the tumor microenvironment displayed particular features, subsequently promoting proinflammatory Th2 and regulatory immune profiles through OX40L and ICOSL expression. Elevated frequencies of interleukin (IL)-5-, IL-13- and IL-10–producing T cells in patients with melanoma correlated with high proportions of OX40L- and ICOSL-expressing pDCs. Strikingly TARC/CCL17, MDC/CCL22, and MMP-2 found in the melanoma microenvironment were associated with pDC accumulation, OX40L and ICOSL modulation, and/or early relapse. Thus, melanoma actively exploits pDC plasticity to promote its progression. By identifying novel insights into the mechanism of hijacking of immunity by melanoma, our study exposes potential for new therapeutic opportunities. Cancer Immunol Res; 1(6); 402–15. ©2013 AACR.