bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis
Authors: Ahanger Sajad Hamid , Zhang Chujing , Semenza Evan R. , Gil Eugene , Cole Mitchel A. , Wang Li , Kriegstein Arnold R. , Lim Daniel A. 
Published: August 2024

AbstractThe nuclear genome is spatially organized into a three-dimensional (3D) architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina at the radial periphery and nuclear speckles within the nucleoplasm1–5. However, how spatial genome architecture regulates human brain development has been overlooked owing to technical limitations. Here, we generate high-resolution maps of genomic interactions with the lamina and speckles in cells of the neurogenic lineage isolated from midgestational human cortex, uncovering an intimate association between subnuclear genome compartmentalization, chromatin state and transcription. During cortical neurogenesis, spatial genome organization is extensively remodeled, relocating hundreds of neuronal genes from the lamina to speckles including key neurodevelopmental genes bivalent for H3K27me3 and H3K4me3. At the lamina, bivalent genes have exceptionally low expression, and relocation to speckles enhances resolution of bivalent chromatin to H3K4me3 and increases transcription >7-fold. We further demonstrate that proximity to the nuclear periphery – not the presence of H3K27me3 – is the dominant factor in maintaining the lowly expressed, poised state of bivalent genes embedded in the lamina. In addition to uncovering a critical role of subnuclear genome compartmentalization in neurogenic transcriptional regulation, our results establish a new paradigm in which knowing the spatial location of a gene is necessary to understanding its epigenomic regulation.
Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells
Authors: Krawczynska Natalia , Wang Yu , Lim Ki , Das Gupta Anasuya , Lenczowski Adam , Abughazaleh Marwan , Bendre Shruti V. , Kockaya Lara I. , Schane Claire P. , Fei Yifan , Hernandez Alvaro G , Drnevich Jenny , Chan Jefferson , Dobrucki Lawrence W. , Boppart Marni D. , Ostrander Julie , Nelson Erik R. 
Published: August 2024

ABSTRACTSmall extracellular vesicles (sEVs) are emerging as critical mediators of intercellular communication in the tumor microenvironment (TME). Here, we investigate the mechanisms by which sEVs derived from neutrophils treated with the cholesterol metabolite, 27-hydroxycholesterol (27HC), influence breast cancer progression. sEVs released from 27HC treated neutrophils enhance epithelial-mesenchymal transition (EMT) and stem-like properties in breast cancer cells, resulting in loss of adherence, increased migratory capacity and resistance to cytotoxic chemotherapy. Decreased microRNAs (miRs) within the sEVs resulted in activation of the WNT/β-catenin signaling pathway in recipient cells and suggest that this may be a predominant pathway for stem-like phenotype and EMT. Our findings underscore a novel mechanism by which 27HC-modulated neutrophils contribute to breast cancer pathophysiology through EV-mediated intercellular communication, suggesting potential therapeutic targets in cancer treatment.
Fractional heterogeneous telegraph processes: Interplay between heterogeneity, memory, and stochastic resetting
Authors: Sandev Trifce , Iomin Alexander 
Published: August 2024

Fractional heterogeneous telegraph processes are considered in the framework of telegrapher's equations accompanied by memory effects. The integral decomposition method is developed for the rigorous treating of the problem. Exact solutions for the probability density functions and the mean squared displacements are obtained. A relation between the fractional heterogeneous telegrapher's equation and the corresponding Langevin equation has been established in the framework of the developed subordination approach. The telegraph process in the presence of stochastic resetting has been studied, as well. An exact expression for both the nonequilibrium stationary distributions/states and the mean squared displacements are obtained.

Published by the American Physical Society
2024
Does audit committee composition influence firm performance? Evidence from the top NSE-listed non-financial companies of India
Authors: Singhania Abhisheck Kumar , Panda Nagari Mohan 
Published: August 2024

PurposeThis study aims to examine the influence of Audit Committee (AC) composition on Firm Performance (FP) by measuring AC composition (ACC) with a composite score based on the varying effect of each composition-characteristic.Design/methodology/approachPartial Least Squares- Structural Equation Modeling (PLS-SEM) technique is used to weigh ACC characteristics. Based on 133 companies and covering five years from 2016 to 2020, the study analyses data after controlling endogeneity through the Gaussian Copula approach.FindingsWe find a significant positive influence of ACC on Firm Performance. Among the ACC characteristics, the absence of executive directors has the highest positive weight on ACC to influence FP, followed by AC size and Gender diversity. AC independence and members' accounting and financial expertise have no significant weight on its composition.Practical implicationsApart from the theoretical contribution, the study reveals that each ACC characteristic has a varying effect on AC effectiveness to influence the FP that needs to be considered by regulators while framing regulations on ACC and by BOD while constituting AC for a company.Originality/valueThe study claims originality by being pioneering to reveal that AC composition, with a synergy of its disparate characteristics, positively impacts FP. It highlights that the absence of executive directors and gender diversity in AC (characteristics overlooked by the extant literature) significantly and positively influence FP. Methodologically, it introduces the use of the PLS-SEM algorithm to weigh the characteristics in governance studies. Further, these findings remain relevant amid recent Indian legal reforms, offering contemporary insights for policy consideration.
Mapping the way to a dark green enterprise: fuzzy cognitive map based analysis of factors affecting environmental performance for sustainable development
Authors: Kocabey Ciftci Pinar 
Published: August 2024

PurposeIt is crucial to transform current enterprises to greener versions of them to reach the sustainable development goals. The first step of this transformation can be understanding comprehensively environmental performances of enterprises. This study presents a practical analysis for evaluation of factors affecting environmental performance of enterprises to call them as a “dark green.”Design/methodology/approachFor this purpose, a detailed factor search was primarily performed and then the weights of them on environmental performance of the enterprises to support sustainable development were analyzed using fuzzy cognitive map (FCM) that incorporates the casual relationships between factors and represents the dynamics of the complex systems. The FCM was also supported with extended great deluge algorithm (EGDA), which is an evolutionary algorithm with high performance to increase robustness of the study.FindingsThe findings indicated that the most influential factors on environmental performance of an activist enterprise are “loyalty to regulations,” “digitalization level,” “tendency to produce environmentally friendly products/services,” “productivity efforts” and “fossil fuel consumption,” respectively. While the first four of them affect the environmental performance positively, fossil fuel consumption affects it negatively.Practical implicationsThe results of this study can help companies to prioritize the critical points for their environmental perspectives, observe at which factors they are good or lacking and find where to start improvement.Originality/valueThis study is one of the pioneering studies to investigate the importance of criteria for a dark green business, considering 21 factors from different sources to make a detailed representation of corporate environmental sustainability.
The influence of the board’s size, independence and sociodemography on the firm’s climate change orientation: evidence from the GALPLACC index
Authors: Lippi Andrea , Galavotti Ilaria 
Published: August 2024

Purpose
This paper aims to explore the relationship between board composition and a firm’s commitment to combatting climate change. Specifically, this study investigates how various characteristics of the board, namely its size and presence of independent directors, and of the directors themselves, including gender diversity, age, educational background and national homogeneity, affect the corporate-level climate change orientation. From a theoretical standpoint, the authors take a cross-fertilizing perspective, bridging upper echelons theory with agency, resource dependence and critical mass theories.

Design/methodology/approach
The study uses ordered probit regression models on a hand-collected multi-country and multi-industry sample of 35 listed firms included in the Global Climate Change Liquid Equity Index (GALPLACC) provided by ECPI. This index is particularly relevant as it focuses on firms that have demonstrated a commitment to climate change, providing a robust dataset for the analysis.

Findings
The findings underscore the importance of disentangling various characteristics of corporate boards and directors. Specifically, the orientation toward climate change is negatively influenced by both board size and having a higher number of independent directors, while it is positively affected by reaching a critical mass of women on the board. Conversely, factors such as average age, educational background and the level of national homogeneity do not show significant effects.

Originality/value
This paper has an exploratory nature and contributes to the ongoing debate on the crucial, yet controversial role played by board-level and directors’ sociodemographic characteristics in shaping a firm’s environmental stance. Moreover, this study offers potential recommendations for policymakers regarding board composition to enhance firms’ climate change orientation.
Cautious or confident? Directors’ and officers’ liability insurance and enterprise strategic change: a model of mediating effect and joint moderating effects
Authors: Li Chao , Huo Mengjun , Liu Renhuai 
Published: August 2024

Purpose
The purpose of this paper is to empirically analyze the impact of directors’ and officers’ (D&O) liability insurance on enterprise strategic change. It also explores the mediating role of litigation risk, the moderating roles of enterprise science and technology level and precipitation organizational slack between them. In addition, it examines the joint moderating roles of the top management team (TMT) external social network and enterprise science and technology level, and enterprise scale and precipitation organizational slack.

Design/methodology/approach
Using the unbalanced panel data of A-share listed companies in the Shanghai and Shenzhen stock exchanges of China from 2002 to 2020 as the research sample, this paper uses the ordinary least square method and fixed-effect model to study the relationship between D&O liability insurance and enterprise strategic change. The study also focuses on the mediating mechanism and moderating mechanisms between them.

Findings
The authors find that D&O liability insurance has an “incentive effect,” which can significantly promote enterprise strategic change. Litigation risk plays a partial mediating role between D&O liability insurance and enterprise strategic change. Enterprise science and technology level and precipitation organizational slack negatively moderate the relationship between D&O liability insurance and enterprise strategic change. TMT external social network and enterprise science and technology level, and enterprise-scale and precipitation organizational slack have joint moderating effects on the relationship between D&O liability insurance and enterprise strategic change.

Originality/value
This paper confirms the “incentive effect hypothesis” of the impact of D&O liability insurance on enterprise strategic change, which not only broadens the research perspective of enterprise strategic management but also further expands the research scope of D&O liability insurance. Besides, this paper thoroughly explores the influencing mechanisms between D&O liability insurance and enterprise strategic change, providing incremental contributions to the research literature in the field of enterprise risk management and corporate governance. The findings have practical guiding significance for expanding the coverage of D&O liability insurance, promoting the implementation of strategic changes and improving the level of corporate governance of Chinese enterprises.
Does ChatGPT generate fake results? Challenges in retrieving content through ChatGPT
Authors: Safdar Muhammad , Siddique Nadeem , Gulzar Ayesha , Yasin Haisim , Khan Muhammad Ajmal 
Published: August 2024

Purpose
ChatGPT is a new development in this technological era. This artificial intelligence-based tool responds to individuals’ queries and produces the requested content within seconds. Therefore, it is becoming popular among academics, the research community and library professionals. This study aims to test (through personal interaction with the tool) the authenticity of the ChatGPT’s produced records. Another objective of the research is to check the relevance between the individuals’ queries and the tool’s results. The research also intends to identify the challenges in retrieving information through ChatGPT.

Design/methodology/approach
The five researchers from different countries and organizations experienced ChatGPT by asking questions on more than 70 subjects. The responses were recorded in Notepad and converted into MS Excel and MS Access to standardize and analyze the data. The investigators consulted 11 reputed databases/sources, including Web of Science and Scopus, to assess the authenticity of the data retrieved through ChatGPT.

Findings
The findings confirmed that over 90% of results produced by ChatGPT were fake (the information did not exist in the literature). Similarly, the study sheds light on the discrepancies, such as irrelevant and incomplete information in the data generated by ChatGPT.

Originality/value
This is a unique study that shares the findings based on the different regions’ researchers’ personal experiences with ChatGPT. The researchers covered different subject areas (above 70) while asking questions to ChatGPT. The paper shares implications for researchers, students, faculty members, academic/research organizations and policymakers.
The role of individual factors in perceived sustainable employability: an application in higher education
Authors: Álvarez-González Paula , López-Miguens María J. , Caballero Gloria 
Published: August 2024

PurposeSustainable employability has emerged as a multifaceted construct that measures individuals' abilities to function in the labour market throughout their working lives. Therefore, it is no longer just about analysing how to achieve a successful transition from school/university to employment, but also about identifying the conditions that will allow people to continue to be capable and motivated in the long term. The aim of this work was to identify and rank the personal factors of an individual that contribute to his or her perceived sustainable employability.Design/methodology/approachThe authors used a quantitative methodology to estimate the structural model proposed. A stratified random procedure was used to administer an online questionnaire to 202 university master’s degree students. Before testing the structural model, the validation of each scale was performed, both at the exploratory and confirmatory levels.FindingsThe results indicate that four groups were key to improve individual sustainable employability: (1) Health Status; (2) Career Competencies; (3) Core Self-Evaluations and (4) Overcoming Competencies.Research limitations/implicationsThe results are of interest to any individual, employed or not, insofar as they can reflect on the relevance of each category and how to improve them at the individual level.Originality/valueThis study contributes to research on sustainable employability focus on the analysis of young people by providing empirical evidence on its relationship with other key variables, in an area where the literature remains mainly conceptual and centred in workers.
Gender and business creation: similarities and differences
Authors: Reynolds Paul D. 
Published: August 2024

PurposeThis paper explores the scope and impact of gender in the process of starting new businesses, with a particular focus on understanding how participation, motivations and outcomes differ between men and women entrepreneurs.Design/methodology/approachThis paper utilizes data from the Global Entrepreneurship Monitor (GEM) and the Panel Studies of Entrepreneurial Dynamics (PSED). The GEM data provide a global overview, drawing from representative national samples across over 100 countries to assess the extent of business creation activity and gender participation globally. The longitudinal PSED data set provides information on the business creation process and outcomes.FindingsOver the last 20 years, the presence of women in the early stages of starting a business in the United States of America has seen a notable increase, doubling their representation among entrepreneurs and nearing parity with men, who also saw growth but at a slower rate. This shift marks a significant move towards greater gender balance in the entrepreneurial landscape.Originality/valueThe originality of this paper lies in its comprehensive analysis of the evolving landscape of gender dynamics within entrepreneurship over two decades, particularly highlighting the significant increase in women's participation in business creation.
Intent to stay of Chinese agency workers in the information technology outsourcing industry
Authors: Zhang Xiwei , Liang Xiaoyan , Xiao Qijie 
Published: August 2024

PurposeThe literature on information technology outsourcing (ITO) prioritises monetary considerations and overlooks human aspects. This qualitative study adopts a contextualised approach to address a research gap in understanding agency workers’ intent to stay in the ITO sector.Design/methodology/approachIn contrast to previous studies that focus on intra-organisational factors and use quantitative designs, this study takes a qualitative approach. It analyses data from 85 in-depth interviews with agency workers in the Chinese ITO supply chain and project managers of supplier and client firms.FindingsThe study constructs an integrated framework covering 15 factors at three levels and shows how they interact to influence Chinese agency workers’ intent to stay in the ITO supply chain. Variations in outsourcing management styles and practices among U.S., Japanese and Chinese client firms are presented to enrich the understanding of outsourcing dynamics in a global context.Originality/valueThis study contributes to the ITO literature by providing new insights into the retention of highly skilled agency workers and deepening the contextual understanding of this issue, throwing light on the human aspects often overshadowed by monetary considerations.
Metaverse, entrepreneurial learning and opportunity exploitation
Authors: Abaddi Samer 
Published: August 2024

Purpose
In the cosmic expanse of the digital universe, a new celestial body emerges the Metaverse. This study embarks on an interstellar journey to scrutinize the dynamics of entrepreneurial learning (EL) and opportunity in the burgeoning realm of the metaverse. This study aims to understand how personal entrepreneurial characteristics (PEC) and Metaverse environment characteristics (MEC) influence these processes.

Design/methodology/approach
The study devotes a dual-lens approach, combining the power of interviews (Phase I) and the precision of a survey (Phase II). It harnesses the insights of the entrepreneurial event model (EEM) and the technology acceptance model (TAM), serving as twin beacons guiding our exploration of the constructs under PEC/MEC.

Findings
The study uncovers a fascinating tapestry of interwoven variables. Certain threads in the PEC/MEC weave significantly into the fabric of EL, which in turn embroiders the pattern of opportunity exploitation. However, some threads, namely, Metaverse scalability, entrepreneurial risk-taking and innovativeness, do not significantly contribute to the design of EL.

Practical implications
The findings serve as a compass for various stakeholders in the metaverse. They guide the design of entrepreneurial education programs, inform the development of user-friendly metaverse platforms, shape policies promoting entrepreneurship in the metaverse and provide strategic insights for entrepreneurs and investors.

Originality/value
This study is a trailblazer, being among the first to apply the EEM and TAM in the context of the Metaverse. It offers fresh perspectives on entrepreneurial processes in virtual environments, enriching the emerging narrative on metaverse entrepreneurship and charting unexplored territories for future research.
Islamic bonds (sukuk) a safe haven for investors? Truth or myth?
Authors: Qadri Hussain Mohi-Ud-Din , Mustafa Atta Ul , Ali Hassnian , Tahir Atta Ul Mustafa 
Published: August 2024

Purpose
This study aims to find whether sukuk (Islamic bonds) possess a safe haven property for investors or not.

Design/methodology/approach
To analyze this statement, the study used data from MSCI World conventional and MSCI World Islamic indices from August 17, 2012 to June 8, 2022. The study used the generalized autoregressive conditional heteroskedasticity (GARCH) variance technique, the most common technique used in stock data analysis.

Findings
The results dictate the absence of sukuk as a safe haven for investors as both the conventional and Islamic markets show decoupling behavior. The study finds concrete evidence of a strong association between the debt-based bond market and the Islamic sukuk market. As these markets mostly like to move in a parallel direction, a recession in a conventional bond market likely means a recession in the Islamic sukuk market.

Originality/value
This study is unique in incorporating the MSCI World Islamic Index and other Islamic indices of several Muslim countries, which was absent in previous research. Second, this study is unique because it adds a separate regression for the COVID era to show whether the movement of indices changed during regression.