bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryptocurrency Trading and Associated Mental Health Factors: A Scoping Review
Authors: Jain Lakshit , Velez-Figueroa Luis , Karlapati Surya , Forand Mary , Ahmed Rizwan , Sarfraz Zouina 
Published: February 2025

Background: Cryptocurrency trading seemingly mirrors the high-risk, high-reward nature of gambling, and may cause significant psychological challenges to traders. As cryptocurrency trading becomes mainstream, this scoping review aims to synthesize evidence from empirical studies to understand the emotional, cognitive, and social influences on cryptocurrency traders, and identify associated mental health traits/attributes influencing their behaviors. Methods: This review adhered to PRISMA-ScR guidelines, pooling in 13 studies involving 11,177 participants across multiple countries. A detailed literature search was conducted up to August 4, 2024, and was rerun on October 9, 2024 using databases including PubMed/Medline, Web of Science, Embase, and Scopus. Keywords used included psychiatry, psychology, mental health, cryptocurrency, trading behavior, mental health, substance use, gambling, investment, and/or emotional impact. These terms were refined through iterative searches to retrieve the most relevant studies. Results: The scoping review found several key psychological factors affecting cryptocurrency trading behaviors. Many traders exhibited addiction-like behaviors, compulsively trading even when it leads to financial losses. Social media was found to have a strong influence, encouraging herd behavior and impulsive decision-making to follow trends. High levels of psychological distress, including anxiety and depression, were found to be linked to the market’s volatility and risks. Overconfidence bias was observed to make traders underestimate risks and overestimate their ability to predict the market. Cognitive biases like confirmation bias and the disposition effect caused traders to hold onto losing investments and sell winning ones too early. Conclusion: Due to the shared psychological traits between cryptocurrency trading and gambling, it is imperative to implement targeted early interventions to mitigate the risk of its progression into a pathological condition. Tools like the Problematic Cryptocurrency Trading Scale may help identify and manage risky behaviors. Ongoing research is crucial to identify both positive and negative impact of cryptocurrency trading to develop effective support systems and regulatory policies to address traders’ mental well-being.
The Impact of Medicaid Expansion on Acute Diabetes Complication by Care Delivery Settings
Authors: Kulbak Danielle , Dinh Dang , Larson Annie E. , Suchocki Andrew , Springer Rachel , Marino Miguel , DeVoe Jennifer E. , Hwang Jun , Huguet Nathalie 
Published: February 2025

Objective: This study evaluates whether gaining Medicaid following the Affordable Care Act (ACA) expansion led to changes in the rate of acute diabetes complications diagnosed in primary care settings, relative to in inpatient, emergency department (ED), or urgent care (UC) settings. Methods: This retrospective cohort study used Medicaid administrative claims data linked to electronic health records for 3767 patients, aged 19 to 64 years, who experienced acute preventable complications of diabetes between 2014 and 2019 diagnosed in inpatient, ED, UC, or primary care settings in the state of Oregon. These patients were classified as either continuously Medicaid-insured or having gained Medicaid. Results: Annual rates of acute complications diagnosed in primary care and inpatient/ED/UC settings increased for both continuously [Adjusted Rate Ratio (aRR) = 2.20, 95% CI = 1.65-2.91] and newly Medicaid-insured patients (aRR = 2.67, 95% CI = 2.05-3.47) after the ACA. Among newly Medicaid-insured, annual rates of abnormal blood glucose diagnosed in primary care settings significantly increased with time while those diagnosed in inpatient/ED/UC decreased (2014 vs 2016 aRR = 3.36, 95% CI = 1.60-7.09). Conclusion: We found a significantly greater rate of abnormal blood glucose diagnosed in primary care clinics among patients who gained Medicaid post-ACA and a corresponding decline in diagnosis in inpatient/ED/UC settings.
Exploring eye-movement changes as digital biomarkers and endophenotypes in subclinical eating disorders: an eye tracking study
Authors: Navas-León Sergio , Sánchez-Martín Milagrosa , Tajadura-Jiménez Ana , De Coster Lize , Borda-Mas Mercedes , Morales Luis 
Published: February 2025

Abstract

Objective
Previous research has indicated that patients with Anorexia Nervosa (AN) exhibit specific eye movement changes, identified through eye tracking sensor technology. These changes have been proposed as potential digital biomarkers and endophenotypes for early diagnosis and preventive clinical interventions. This study aims to explore whether these eye movement changes are also present in individuals with subclinical eating disorder (ED) symptomatology compared to control participants.

Method
The study recruited participants using convenience sampling and employed the Eating Disorder Examination Questionnaire for initial screening. The sample was subsequently divided into two groups: individuals exhibiting subclinical ED symptomatology and control participants. Both groups performed various tasks, including a fixation task, prosaccade/antisaccade task, and memory-guided task. Alongside these tasks, anxiety and premorbid intelligence were measured as potential confounding variables. The data were analyzed through means comparison and exploratory Pearson’s correlations.

Results
No significant differences were found between the two groups in the three eye tracking tasks.

Discussion
The findings suggest that the observed changes in previous research might be more related to the clinical state of the illness rather than a putative trait. Implications for the applicability of eye movement changes as early biomarkers and endophenotypes for EDs in subclinical populations are discussed. Further research is needed to validate these findings and understand their implications for preventive diagnostics.

Registration

https://jeatdisord.biomedcentral.com/articles/10.1186/s40337-022-00573-2
Health related quality of life (HRQOL) from the perspective of patients with chronic whiplash-associated disorders (WAD) in Sweden
Authors: Dalal Koustuv , Peterson Gunnel , Peolsson Anneli 
Published: February 2025

Abstract

Background
The current study investigated Whiplash Associated Disorders (WAD) and health related quality of life (HRQOL) from the perspective of Swedish patients. Another aim was to assess medicine consumption and income loss due to WAD.

Method
The present study was a planned secondary analysis using baseline data from a prospective, multicentre randomized controlled trial. The study participants were WAD patients, victims of four-wheel motor vehicle collisions at least six months but not more than five years ago. Neck Disability Index and HRQOL were measured. HRQOL was measured by the EQ-5D instrument. Cross tabulations, Box Plots, and regression analyses were performed.

Trial registration section
The study was registered before data collection started (ClinicalTrials.gov Protocol ID: NCT03022812, initial release 12/20/2016).

Results
There were 137 WAD participants (78.8% women), and almost three-fourths (74.5%) were married. The majority (54.7%) of the WAD patients were in white-collar jobs, followed by blue-collar jobs (35%) and students /unemployed (10.2%). Both consumption of medicine for neck pain and income loss due to WAD have a negative relation with the Neck Disability Index (NDI). On average, EQ-VAS for WAD women is 58.21 (± 17.625), and for men, it is 61.11 (± 16.444). WAD patients with a university education have the highest EQ-VAS average of 60.42 (± 17.738).

Conclusions
The low HRQOL seen in WAD patients in this study should warrant the attention of the medical fraternity, researchers and policymakers.
Effect of add-on therapy with leukotriene receptor antagonists and Chungsangboha-tang in patients with asthma: a protocol for a randomized, placebo-controlled, parallel, multicenter trial
Authors: Kang Sung-Woo , Nam Hae-Seong , Park Yang-Chun , Choi Jun-Yong , Kim Ki-Tae , Ha Seo-Jung , Kim Kwan-Il , Jung Hee-Jae , Lee Beom-Joon 
Published: February 2025

Abstract

Background
Asthma is a chronic disease characterized by airway inflammation and obstruction. Treatment aims to control symptoms with minimal medication, using disease-controlling and symptom-relieving drugs. Inhaled steroids and beta2 agonists are common treatments; however, their long-term use can cause side effects. Leukotriene receptor antagonists (LTRAs) are used in combination with inhaled steroids to manage asthma because of their anti-inflammatory and bronchodilatory effects. Combining LTRAs with Chungsangboha-tang (CSBHT), a Korean medicine, may enhance their efficacy. This study aimed to evaluate the potential of CSBHT as an adjunctive therapy for asthma management in a randomized, placebo-controlled, double-blind, multicenter clinical trial.

Methods
This randomized, placebo-controlled, double-blind, parallel-group, multicenter study aims to evaluate the efficacy and safety of CSBHT as an additional treatment for patients with asthma, particularly for those with LTRAs. Overall, 198 participants will be randomly divided into intervention and control groups, with the former receiving CSBHT thrice daily and the latter receiving a placebo. Follow-ups at weeks 0, 4, and 8 will include outcome measurements, medication dispensation, and adverse reaction monitoring. The primary outcome is the mean change in forced expiratory volume in one-second scores, with secondary outcomes including changes in peak expiratory flow, forced vital capacity, forced expiratory flow 25–75%, fractional exhaled nitric oxide, Asthma Control Test, Asthma Quality of Life Questionnaire, serum IgE, eosinophil count, C-reactive protein, rescue medication usage, and a descriptive analysis of the questionnaire on asthma symptoms in Korean medicine. Safety assessments will be conducted using laboratory tests, vital signs, and monitoring of adverse events. Economic evaluations will be conducted using either cost-minimization analysis or cost-utility analysis.

Discussion
This trial will evaluate the efficacy, safety, and cost-effectiveness of CSBHT as an add-on therapy to LTRAs to establish its potential as an adjuvant therapy in asthma management.

Trial registration
This study was registered in the Clinical Research Information Service of Korea (KCT0006005), on March 16, 2021.
The impact of polycystic ovary syndrome on attention: an empirical investigation
Authors: Redkar Maitreyi , Khan Azizuddin 
Published: February 2025

Abstract

Background
Polycystic Ovary Syndrome (PCOS) is an endocrinal dysfunction characterized by androgen excess, irregular or absent menstruation, and polycystic ovarian morphology. While extensive research is conducted on the biochemical and medical ramifications of PCOS. However, there is not much research on cognitive mechanisms, especially attention. Attention is the fundamental cognitive ability that influences other cognitive and psychological phenomena. Therefore, the present study attempts to investigate the effect of PCOS on attention.

Methods
Flanker’s task examining focussed attention and Posner’s cueing task measuring divided attention was administered to 173 female participants, of which 101 constituted the PCOS group and the remaining were control. The Analysis of Variance was used to analyze the data.

Results
These findings demonstrated that the PCOS group took longer in focused attention, 557.21 milliseconds (SD = 169.70), compared to the reaction time of 462.88 milliseconds (SD = 120.80) in divided attention. Concerning accuracy, the PCOS group made more errors in the focused attention task at 0.98 (SD = 0.41), while for the divided attention task, it was 0.99 (SD = 0.27).

Conclusions
Women with PCOS showed more error and slower reaction time in focused attention.
High albumin leakage rather than increased dialysis dose can increase the α1-microglobulin reduction ratio in patients on predilution online hemodiafiltration
Authors: Okada Kazuyoshi , Tashiro Manabu , Michiwaki Hiroyuki , Yamaguchi Sumiyo , Inoue Tomoko , Minakuchi Jun 
Published: February 2025

Abstract

Background
When increasing the reduction ratio (RR) of α1-microglobulin (α1MG) to improve symptoms, the dialysis dose is usually increased. However, no studies on its effectiveness have been reported.

Methods
This cross-sectional study included 113 patients on predilution online hemodiafiltration (pre-OHDF) as of 1 July 2023. Univariate and multiple regression analyses were performed to investigate factors associated with the RR of α1MG.

Results
In univariate analysis, the RR of α1MG was significantly correlated with age, normalized protein catabolism rate (nPCR), membrane surface area, blood flow rate, ultrafiltration volume, and albumin leakage, but not with body mass index, albumin, C-reactive protein, substitution volume, transmembrane pressure, or Kt/V.
In multiple regression analysis, the RR of α1MG remained significantly correlated with nPCR (P = 0.007) and albumin leakage (P < 0.001).

Conclusions
These findings suggest that in patients undergoing pre-OHDF with high protein intake, the use of high albumin leakage membranes rather than increasing the dialysis dose can significantly increase the RR of α1MG.

Trial registration UMIN Clinical Trials Registry, UMIN000055718. Prospectively registered 3 October 2024. https://center6.umin.ac.jp/cgi-bin/ctr/ctr_view_reg.cgi?recptno=R000063229
Safety and Efficacy of Neoadjuvant Durvalumab Plus Gemcitabine/Cisplatin or Carboplatin in Patients With Operable High-Risk Upper Tract Urothelial Carcinoma: The iNDUCT-GETUG V08 Trial
Authors: Houédé Nadine , Chevallier Thierry , Audenet François , Thibault Constance , Neuzillet Yann , Abraham Christine , Masson-Lecomte Alexandra , Gauthier Hélène , Gravis Gwenaëlle , Pignot Géraldine , Tartas Sophie , Ruffion Alain , Pouessel Damien , Roumiguié Mathieu , Laguerre Brigitte , Bensalah Karim , Xylinas Evanguelos , Jaffrelot Loïc , Droupy Stéphane , Luquiens Guillaume , Rouprêt Morgan 
Published: February 2025

PURPOSE
After radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), prognosis is poor for high-risk patients. This study evaluated safety and efficacy of neoadjuvant chemotherapy (cisplatin or carboplatin + gemcitabine) in combination with durvalumab in these patients.

PATIENTS AND METHODS

This phase II trial (ClinicalTrials.gov identifier:
NCT04617756
) included patients with nonmetastatic, high-grade UTUC, on the basis of the ureteroscopic biopsy or urine cytology, and/or infiltrative aspect of the renal pelvis/ureteral wall by computed tomography imaging. Before RNU, patients received durvalumab plus gemcitabine/cisplatin (cohort 1) or durvalumab plus gemcitabine/carboplatin (cohort 2) once every 3 weeks for a total of four cycles (cohort choice on the basis of the glomerular filtration rate). The primary objective was the pathologic complete response (ypT0) rate in each cohort.

RESULTS
Fifty patients were enrolled between 2021 and 2024 (31 in cohort 1; 19 in cohort 2). Median age was 68 years (range, 38-79), and 59% were men. Forty-five patients received four cycles of treatment, three patients three cycles, and one patient two cycles. Five patients switched to carboplatin during treatment. At surgery (N = 45 patients), rates of pT0 were 13% (4/29) in cohort 1 and 5% (1/19) in cohort 2. Fifty percent (15/29) of patients were pTa/pT1 in cohort 1, and 42% (8/19) in cohort 2. No severe immunotherapy-mediated toxicity was observed. Four patients had chemotherapy-related grade 3 neutropenia, one grade 4; one patient had grade 3 thrombopenia, one grade 4; and four patients had grade 3 anemia.

CONCLUSION
Although our negative study did not meet its primary end point in either cohort, the combination of durvalumab and platin-based chemotherapy, especially cisplatin, showed promising results in terms of downstaging. The safety profile was good and the surgical risk was not increased.
Integral Roles of the TGFβ Signaling Pathway in Uterine Function and Disease
Authors: Unser Anna Catherine , Monsivais Diana 
Published: February 2025

Abstract
The uterus is a complex organ that requires precise signaling networks to mediate functions necessary for homeostasis and reproductive processes. The transforming growth factor β (TGFβ) superfamily regulates integral signaling pathways throughout many physiological processes, including cell proliferation, differentiation, and development. In this review, we summarize the current understanding of how the TGFβ signaling family controls key uterine functions, with a specific focus on the endometrium. These uterine functions include endometrial receptivity, implantation, decidualization, placentation, remodeling, and regeneration. Improving our understanding of the signaling networks that regulate these processes is integral to identifying, diagnosing, and treating uterine and reproductive diseases such as endometriosis, adenomyosis, recurrent pregnancy loss, and recurrent implantation failure.
A Settler-Colonial Genealogy of Modernism: Albert Camus and the Aesthetics of Elimination
Authors: Dalley Hamish 
Published: February 2025

Abstract
This article explores the influence of settler colonialism on the emergence and development of literary modernism in the mid-twentieth century. It focuses on Algeria-born Albert Camus's first novel, L’étranger (1942), questioning the critical tendency to read this work solely in relation to metropolitan literary and philosophical trends. Recontextualizing L’étranger with regard to a largely forgotten corpus of French-Algerian colonial fiction, including novels by Louis Bertrand, Robert Randau, and Paul Achard, reveals parallels between Camus's “absurd hero” and the hypermasculine and violent protagonists often idealized in this cultural milieu. Reading L’étranger within a French-Algerian context suggests that Meursault's “existential” transcendence of conventional morality emerges within the ideological nexus of settler colonialism—a situation defined by the need to eliminate the indigenous population while disavowing responsibility for doing so. This analysis suggests tantalizing connections between the aesthetic innovations commonly called modernism and the material-affective structures of settler violence. Such parallels make it important to consider the frontier as a space that is central to the cultural developments of modern literary history.
Generic Gayness: Andrew Holleran's Dancer from the Dance and a Not-So-Grand Theory of the Gay Novel
Authors: Davidson Guy 
Published: February 2025

Abstract
The novel has been widely acknowledged as a historically significant factor in the construction of gay identities, and the novel is central to queer literary studies. Yet the genre of the gay novel is curiously undertheorized. Scholars seldom address the transformations wrought on the novel by engagements with queerness, generally treating it as simply a delivery system for queer representation and queer affect. This essay addresses this gap in queer literary studies through an analysis of Andrew Holleran's Dancer from the Dance (1978) as a hyperparadigmatic example of the gay novel. Deploying novel theory and genre theory, this article argues that Dancer indicates how gayness transforms the novel and how the novel enables the lived experience of gay identity. Dancer, and the gay novel generally, complicate novel theory's assumption that the genre always privileges the individual over the collective. The “marked” form of individuality that is gay identity is often suffused by collectivity in a way that is not the case in novels with “unmarked” protagonists. The simultaneously personal and collective dimensions of gay life are also evident in the reception of gay novels. Like other examples of what Lauren Berlant calls the “minoritized arts,” Dancer provides “a complex of consolation, confirmation, discipline, and discussion about how to live as an x.” Dancer has been the focus of intense and enduring forms of “discussion about how to live” as a gay man, and it therefore provides a particularly informative instance of the gay novel's cultural work.
“She Knew She Ought to Be Happy”: Socialized Subjects in Emma
Authors: Stasi Paul 
Published: February 2025

Abstract
This article argues that we have consistently misunderstood Jane Austen's subjects by assimilating them to a political liberalism in which she was uninterested. What matters in Austen is not subjective interiority so much as social status; her presentation of character resists the abstract equality characteristic of liberalism, which separates individuals from their social worlds. In contrast, Austen's subjects are almost entirely social. Tying Austen's presentation of the subject to the famous theses by Tom Nairn and Perry Anderson about the particular class compromise characteristic of English society, this article reads socialization in Emma as ideological and utopian in equal measure, suggesting a positive side to the socialization that a critical tradition invested in liberalism can only see as ideological inscription.
Constructing Attachment: Persistent and Elided Speech in Jane Austen's Novels
Authors: Menon Tara K. 
Published: February 2025

Abstract
This article argues that theorists of the novel have consistently overlooked direct speech even though it proliferates in realist fiction. Using the novels of Jane Austen as a case study, I show how close attention to direct speech can improve our understanding of both major and minor characters as well as the complex relations between characters. Using computational tools alongside close analysis of scenes in Pride and Prejudice, Emma, Sense and Sensibility, and Mansfield Park, I identify two recurrent features in the representation of direct speech across Austen's novels: what I call “persistent” and “elided” speech. By identifying and analyzing the effects of persistent and elided speech, I provide new answers to long-standing questions about affective responses to literary characters such as: What are the narrative mechanisms that create readerly affect? How is it that readers feel for or about fictional characters? Why do readers dislike or like specific characters?