bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the internal modes on the sphaleron decay
Authors: Navarro-Obregón S. , Queiruga J. 
Published: August 2024

AbstractWe study the sphaleron solutions in two deformations of the $$\phi ^6$$

ϕ
6

model and analyze the oscillons originated from them. We find that the presence of internal modes plays a crucial role in the sphaleron collapse. The positive internal modes triggered by a squeezing of the sphaleron are able to change the direction of collapse. We provide an analytical understanding behind this phenomenon.
Data from Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Authors: Ma Xiaojun , Lembersky David , Kim Elena S. , Becich Michael J. , Testa Joseph R. , Bruno Tullia C. , Osmanbeyoglu Hatice U. 
Published: August 2024

<div>Abstract<p>Immunotherapies have demonstrated limited clinical efficacy in malignant mesothelioma treatment. We conducted multiplex immunofluorescence analyses on tissue microarrays (<i>n</i> = 3) from patients with malignant pleural mesothelioma (MPM, <i>n</i> = 88) and malignant peritoneal mesothelioma (MPeM, <i>n</i> = 25). Our study aimed to elucidate spatial distributions of key immune cell populations and their association with lymphocyte activation gene 3 (LAG3), BRCA1-associated protein 1 (BAP1), neurofibromatosis type 2 (NF2), and methylthioadenosine phosphorylase (MTAP), with MTAP serving as a cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/B) surrogate marker. Additionally, we examined the relationship between the spatial distribution of major immune cell types and prognosis and clinical characteristics of patients with malignant mesothelioma. We observed a higher degree of interaction between immune cells and tumor cells in MPM compared with MPeM. Notably, within MPM tumors, we detected a significantly increased interaction between tumor cells and CD8<sup>+</sup> T cells in tumors with low BAP1 expression compared with those with high BAP1 expression. To support the broader research community, we have developed The Human Spatial Atlas of Malignant Mesothelioma, containing hematoxylin and eosin and multiplex immunofluorescence images with corresponding metadata.</p>Significance:<p>Considering the limited therapeutic options available to patients with malignant mesothelioma, there is substantial translational potential in understanding the correlation between the spatial architecture of the malignant mesothelioma tumor immune microenvironment and tumor biology. Our investigation reveals critical cell–cell interactions that may influence the immune response against malignant mesothelioma tumors, potentially contributing to the differential behaviors observed in MPM and MPeM. These findings represent a valuable resource for the malignant mesothelioma cancer research community.</p></div>
The Law of International Responsibility Situated: From Halcyon Days to a Fragmented Global Order
Authors: Creutz Katja 
Published: August 2024

Abstract
The question of how international responsibility fares following the Russian aggression against Ukraine has become commonly discussed and explored. This article argues that the context is nevertheless more complicated as the global order is changing due to power shifts. International norms and institutions as Western states used to know them are no longer secure, but subject to great power contestation leaving it unclear if and how practices, pursuits and invocations of international responsibility change. By analysing, in turn, three institutional snapshots of responsibility from the UN General Assembly, the International Court of Justice, and the International Criminal Court respectively, the article identifies three themes prevalent in current responsibility practices: lawfare, short-term goals like prevention, and accusations of double standards. These attributes reflect the tensions of the reordering of the global order and stands far apart from the story of progress that characterised international responsibility in the Halcyon Days of the 1990s.
Artificial Intelligence-Assisted MRI Diagnosis in Lumbar Degenerative Disc Disease: A Systematic Review
Authors: Liawrungrueang Wongthawat , Park Jong-Beom , Cholamjiak Watcharaporn , Sarasombath Peem , Riew K. Daniel 
Published: August 2024

Study Design Systematic review. Objectives Lumbar degenerative disc disease (DDD) poses a significant global health care challenge, with accurate diagnosis being difficult using conventional methods. Artificial intelligence (AI), particularly machine learning and deep learning, offers promising tools for improving diagnostic accuracy and workflow in lumbar DDD. This study aims to review AI-assisted magnetic resonance imaging (MRI) diagnosis in lumbar DDD and discuss current research for clinical use. Methods A systematic search of electronic databases identified studies on AI applications in MRI-based lumbar DDD diagnosis, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Search terms included combinations of “Artificial Intelligence,” “Machine Learning,” “Deep Learning,” “Low Back Pain,” “Lumbar,” “Disc,” “Degeneration,” and “MRI,” targeting studies in English from January 1, 2010, to January 1, 2024. Inclusion criteria encompassed experimental and observational studies in peer-reviewed journals. Data extraction focused on study characteristics, AI techniques, performance metrics, and diagnostic outcomes, with quality assessed using predefined criteria. Results Twenty studies met the inclusion criteria, employing various AI methodologies, including machine learning and deep learning, to diagnose lumbar DDD manifestations such as disc degeneration, herniation, and bulging. AI models consistently outperformed conventional methods in accuracy, sensitivity, and specificity, with performance metrics ranging from 71.5% to 99% across different diagnostic objectives. Conclusion The algorithm model provides a structured framework for integrating AI into routine clinical practice, enhancing diagnostic precision and patient outcomes in lumbar DDD management. Further research and validation are needed to refine AI algorithms for real-world application in lumbar DDD diagnosis.
Analysis of Determinants of Stunting and Identifications of Stunting Risk Profiles Among Under 2-Year-Old Children in Ethiopia. A Latent Class Analysis
Authors: Fikrie Anteneh , Adula Berhanu , Beka Jitu , Hailu Dejene , Kitabo Cheru Atsmegiorgis , Spigt Mark 
Published: August 2024

Background Childhood stunting has a long-term impact on cognitive development and overall well-being. Understanding varying stunting profiles is crucial for targeted interventions and effective policy-making. Therefore, our study aimed to identify the determinants and stunting risk profiles among 2-year-old children in Ethiopia. Methods and materials A cross-sectional study was conducted on 395 mother–child pairs attending selected public health centers for growth monitoring and promotion under 5 outpatient departments and immunization services. The data were collected by face-to-face interviews, with the anthropometric data collected using the procedure stipulated by the World Health Organization. The data were entered using Epi Data version 4.6 and exported to STATA 16 and Jamovi version 2.3.28 for analysis. Bayesian logistic regression analysis was conducted to identify potential factors of stunting. Likewise, lifecycle assessment analysis (LCA) was used to examine the heterogeneity of the magnitude of stunting. Results The overall prevalence of stunting in children under 24 months was 47.34% (95% confidence interval (CI): 42.44-52.29%). The LCA identified 3 distinct risk profiles. The first profile is Class 1, which is labeled as low-risk, comprised 23.8% of the children, and had the lowest prevalence of stunting (23.4%). This group characterized as having a lower risk to stunting. The second profile is Class 2, which is identified as high-risk, comprised 47.1%, and had a high prevalence of stunting (66.7%), indicating a higher susceptibility to stunting compared to Class 1. The third profile is Class 3, which is categorized as mixed-risk and had a moderate stunting prevalence of 35.7%, indicating a complex interplay of factors contributing to stunting. Conclusion Our study identified 3 distinct risk profiles for stunting in young children. A substantial amount (almost half) is in the high-risk category, where stunting is far more common. The identification of stunting profiles necessitates considering heterogeneity in risk factors in interventions. Healthcare practitioners should screen, provide nutrition counseling, and promote breastfeeding. Policymakers should strengthen social safety nets and support primary education.
The response of labour demand to different COVID-19 containment measures: evidence from online job postings in Austria
Authors: Leitner Sandra M. , Reiter Oliver 
Published: August 2024

AbstractThis paper analyses changes in the speed of labour demand for new hires in response to the lockdowns that were repeatedly put in place to contain the spread of the COVID-19 pandemic. It tests whether the uncertainty-reducing effect of similar lockdowns occurring in quick succession increased the responsiveness of the labour market, thereby allowing for more rapid adjustment, both at the beginning and at the end of subsequent lockdowns. It uses high-frequency online job-posting data and applies an event study approach to the beginning of three national lockdowns and the subsequent reopening in Austria between 2020 and 2022. In view of the importance of progress in vaccination for labour market recovery, it also looks at vaccine roll-out as an additional COVID-19 containment measure, with 2021 as the main roll-out period. The results indicate very different responses to the three lockdowns, with a decline in job-posting activity of between 47 and 50% during the first lockdown and of between 29 and 31% during the second; but an increase of 23% to 28% during the last lockdown. Moreover, responses to the first lockdown were sluggish, with a slow decline at the beginning and a very slow recovery after it was lifted; but over subsequent lockdowns the responses were more rapid and more symmetrical. Responses to the various events differed by occupation and industry: the strongest responses were to be observed in the highly skilled and more-teleworkable occupations of technicians, and managers and professionals, who were badly affected during the first lockdown; the leisure and hospitality industry, which was the hardest hit on account of the mandatory closures and the widespread travel restrictions and bans, and which recovered only very slowly; and the IT, internet and telecommunications industry, where posting activity developed in a direction opposite to that seen in the other industries. Finally, there is little robust evidence of a differentiated effect of vaccinations during lockdowns, suggesting that vaccination roll-out did not have an additional demand-generating effect, over and above the lockdowns.
Effect of group antenatal care versus individualized antenatal care on birth preparedness and complication readiness: a cluster randomized controlled study among pregnant women in Eastern Region of Ghana
Authors: Kukula Vida A. , Awini Elizabeth , Ghosh Bidisha , Apetorgbor Veronica , Zielinski Ruth , Amankwah Georgina , Ofosu Winfred K. , James Katherine , Williams John E. O. , Lori Jody R. , Moyer Cheryl A. 
Published: August 2024

Abstract
Background
As utilization of individual antenatal care (I-ANC) has increased throughout sub-Saharan Africa, questions have arisen about whether individual versus group-based care might yield better outcomes. We implemented a trial of group-based antenatal care (G-ANC) to determine its impact on birth preparedness and complication readiness (BPCR) among pregnant women in Ghana.

Methods
We conducted a cluster randomized controlled trial comparing G-ANC to routine antenatal care in 14 health facilities in the Eastern Region of Ghana. We recruited women in their first trimester to participate in eight two-hour interactive group sessions throughout their pregnancies. Meetings were facilitated by midwives trained in G-ANC methods, and clinical assessments were conducted in addition to group discussions and activities. Data were collected at five timepoints, and results are presented comparing baseline (T0) to 34 weeks’ gestation to 3 weeks post-delivery (T1) for danger sign recognition, an 11-point additive scale of BPCR, as well as individual items comprising the scale.

Results
1285 participants completed T0 and T1 assessments (N = 668 I-ANC, N = 617, G-ANC). At T1, G-ANC participants were able to identify significantly more pregnancy danger signs than I-ANC participants (mean increase from 1.8 to 3.4 in G-ANC vs. 1.7 to 2.2 in I-ANC, p < 0.0001). Overall BPCR scores were significantly greater in the G-ANC group than the I-ANC group. The elements of BPCR that showed the greatest increases included arranging for emergency transport (I-ANC increased from 1.5 to 11.5% vs. G-ANC increasing from 2 to 41% (p < 0.0001)) and saving money for transportation (19–32% in the I-ANC group vs. 19–73% in the G-ANC group (p < 0.0001)). Identifying someone to accompany the woman to the facility rose from 1 to 3% in the I-ANC group vs. 2–20% in the G-ANC group (p < 0.001).

Conclusions
G-ANC significantly increased BPCR among women in rural Eastern Region of Ghana when compared to routine antenatal care. Given the success of this intervention, future efforts that prioritize the implementation of G-ANC are warranted.

Trial registration
ClinicalTrials.gov Identifier: NCT04033003 (25/07/2019).

Protocol available
Protocol Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508671/.
Comparative effectiveness analysis of survival with first-line palbociclib or ribociclib plus AI in HR + /HER2- advanced breast cancer (CEPRA study): preliminary analysis of real-world data from Thailand
Authors: Dajsakdipon Thanate , Susiriwatananont Thiti , Wongkraisri Concord , Ithimakin Suthinee , Parinyanitikul Napa , Supavavej Archara , Dechaphunkul Arunee , Sunpaweravong Patrapim , Neesanun Sunee , Akewanlop Charuwan , Dejthevaporn Thitiya ,   TSCO Breast Oncology Group
Published: August 2024

Abstract
Background
The current standard first-line treatment for hormone receptor-positive/human epidermal growth factor receptor 2 negative (HR + /HER2 −) advanced breast cancer (ABC) is a combination of aromatase inhibitor (AI) plus CDK4/6 inhibitors (CDK4/6i). Direct comparison trials of different CDK4/6i are scarce. This real-world study compared the effectiveness of first-line AI plus ribociclib versus palbociclib.

Methods
This multicenter retrospective cohort study, conducted in six cancer centers in Thailand, enrolled patients with HR + /HER2 − ABC treated with first-line AI, and either ribociclib or palbociclib. Propensity score matching (PSM) was performed. The primary endpoint was overall survival (OS). Secondary endpoints included progression-free survival (PFS), overall response rate (ORR), time to chemotherapy (TTC), and adverse events.

Results
Of the 250 patients enrolled, 134 patients with ribociclib and 49 patients with palbociclib were captured after PSM. Baseline characteristics were well-balanced between groups. Median PFS in patients receiving ribociclib and palbociclib were 27.9 and 31.8 months, respectively (hazard ratio: 0.87; 0.55–1.37). The median OS in the AI + ribociclib arm was 48.7 months compared to 59.1 months in the AI + palbociclib arm (hazard ratio: 0.55; 0.29–1.05). The median TTC in the AI + palbociclib group was 56 months, but not reached in the AI + ribociclib group (p = 0.42). The ORR of AI + ribociclib and AI + palbociclib were comparable (40.5% vs. 53.6%, p = 0.29). Patients receiving palbociclib demonstrated a higher proportion of neutropenia compared to those receiving ribociclib, despite a similar dose reduction rate (p = 0.28). Hepatitis rate was similar between the ribociclib (21%) and palbociclib groups (22%). Additionally, a low incidence of QT prolongation was observed in both the ribociclib (5%) and palbociclib groups (4%).

Conclusion
This preliminary analysis of a real-world study demonstrated the comparable effectiveness of ribociclib and palbociclib with AI as an initial therapy for HR + /HER2 − ABC. No statistically significant difference in PFS, OS, and TTC was found in patients treated with AI combined with palbociclib or ribociclib. Longer follow-up and further prospective randomized head-to-head studies are warranted.
Emergency infection prevention and control training in fragile, conflict-affected or vulnerable settings: a scoping review
Authors: Brainard Julii , Swindells Isabel Catalina , Wild Joanna , Hammer Charlotte Christiane , Hornsey Emilio , Mahamed Hibak Osman , Willet Victoria 
Published: August 2024

Abstract
Background
It is uncertain what could be the best training methods for infection prevention and control when an infectious disease threat is active or imminent in especially vulnerable or resource-scarce settings.

Methods
A scoping review was undertaken to find and summarise relevant information about training modalities, replicability and effectiveness of IPC training programmes for clinical staff as reported in multiple study designs. Eligible settings were conflict-affected or in countries classified as low-income or lower-middle income (World Bank 2022 classifications). Search terms for LILACS and Scopus were developed with input of an expert working group. Initially found articles were dual-screened independently, data were extracted especially about infection threat, training outcomes, needs assessment and teaching modalities. Backwards and forwards citation searches were done to find additional studies. Narrative summary describes outcomes and aspects of the training programmes. A customised quality assessment tool was developed to describe whether each study could be informative for developing specific future training programmes in relevant vulnerable settings, based on six questions about replicability and eight questions about other biases.

Findings
Included studies numbered 29, almost all (n = 27) were pre-post design, two were trials. Information within the included studies to enable replicability was low (average score 3.7/6). Nearly all studies reported significant improvement in outcomes suggesting that the predominant study design (pre-post) is inadequate to assess improvement with low bias, that any and all such training is beneficial, or that publication bias prevented reporting of less successful interventions and thus a informative overview.

Conclusion
It seems likely that many possible training formats and methods can lead to improved worker knowledge, skills and / or practice in infection prevention and control. Definitive evidence in favour of any specific training format or method is hard to demonstrate due to incomplete descriptions, lack of documentation about unsuccessful training, and few least-biased study designs (experimental trials). Our results suggest that there is a significant opportunity to design experiments that could give insights in favour of or against specific training methods. “Sleeping” protocols for randomised controlled trials could be developed and then applied quickly when relevant future events arise, with evaluation for outcomes such as knowledge, practices, skills, confidence, and awareness.
Socioeconomic inequality in breakfast skipping among Norwegian adolescents
Authors: Hovdenak Ingrid Marie , Helleve Arnfinn , Wolden Ida Emilie , Bere Elling 
Published: August 2024

Abstract
Background
Skipping breakfast is associated with negative health-related and school-related outcomes. Breakfast is the most frequently skipped meal among adolescents. Thus, there is a need to explore the reasons for breakfast skipping across population subgroups to better inform policy makers. The purpose of this study was to present the prevalence of adolescents skipping breakfast on schooldays, analyse the reasons for skipping breakfast and assess associations between the prevalence of skipping breakfast and the reasons for skipping breakfast according to sociodemographic variables.

Methods
The data of a random sample of 10 000 upper secondary school students (aged 16–18 years) from Viken County, Norway, were collected. Students completed a questionnaire measuring breakfast skipping, reasons for skipping breakfast, and sociodemographic variables. Chi-square tests were used to assess differences between the independent groups (family affluence scale (FAS), parental education, and gender) and skipping breakfast and reasons for skipping breakfast.

Results
22% of adolescents reported that they usually skipped breakfast on all schooldays. Skipping breakfast was more prevalent among females, older students, students with lower socioeconomic status and students in vocational education programmes. The difference in breakfast skipping between students with low and high FAS scores was 31% versus 16%, respectively. The most common self-reported reasons for skipping breakfast were time (59%) and not wanting to eat breakfast (48%). Furthermore, 9% reported health issues, and 3% reported economic constraints as a reason for skipping breakfast. Not wanting to eat breakfast was related to a higher FAS score, health issues were more common among girls, and economic constraints were more common among those with low socioeconomic status.

Conclusions
Skipping breakfast was common among Norwegian upper secondary school students. Lack of time and not wanting breakfast were clearly the most cited reasons for skipping breakfast. Health issues and economic constraints were also cited but were less common. The results showed diverging associations between different demographic characteristics and reasons for skipping breakfast. These results are important for developing effective programs to improve diet among adolescents.
The individualized treatment for minimally invasive repair of pectus carinatum in adolescent: a single center’ s retrospective study
Authors: Ran Xudong , Shen Weijia , Li Xin , Liao Jianyi , Yuan Hongliang , Wang Hao , Wu Songhua , Rong Shuhan 
Published: August 2024

Abstract
Background
Pectus carinatum (PC) mainly present at the growth spurt time of the early teenage years or the puberty. Poor outer appearance is a major reason for seeking help for surgeons to increase self-confidence and self-esteem. At present, minimally invasive repair (MIR) is one of effective ways to correct the chest wall deformity. Therefore, there is great practical significance to conduct clinical research on MIR about the adolescent PC.

Methods
We applied Abramson procedure in PC group or we applied Abramson procedure and Nuss procedure in PC/PE group. We retrospectively reviewed the results of 41 cases who underwent the surgical correction at our department from January 2020 to April 2023.

Results
All the procedures were successfully done without severe complications. The median operation Time was 80 min in PC group while was 130 min in PC/PE group. The median LOS were 4 days in PC group while 5 days in PC/PE group. The median compression depth was 32 mm in PC group while 12 mm in PC/PE group. Postoperatively, there are some complications. All Pneumothorax patients being treated conservatively were found in 9 patients in two groups. One patient suffered overcorrection after operation. There were 3 patients suffered steel wires breakage in two groups. One patient reoperation postoperatively for the dislocation of the bar secondary to steel wires breakage.

Conclusions
The Abramson procedure or Abramson procedure and Nuss procedure have good short-term results in repair PC and PC/PE. Select one or two procedures should be done individually based on whether the lower plane over depressed after Abramson procedure.