bluuebunny/crossref_metadata_2025_split huggingface dataset:
La paroisse Saint-Louis de Strasbourg administrée par les chanoines réguliers lorrains
Authors: Andriot Cédric 
Published: October 2012

Avec l’époque moderne, le temps était venu pour les congrégations religieuses de redéfinir leurs fonctions. Certaines, comme la congrégation lorraine de Notre-Sauveur, décidèrent de s’orienter vers la pastorale. Or la ville de Strasbourg, devenue française à la fin du XVIIe siècle, offrait un champ d’expérimentation nouveau pour ces religieux déterminés à faire progresser leur foi au-delà de la dorsale catholique, en cette terre de mission qu’était l’Alsace protestante. Toutefois, le bilan ne fut pas à la hauteur des attentes de la monarchie et des espérances des religieux : une fois passé l’enthousiasme des premières années, la paroisse Saint-Louis de Strasbourg se limita à entretenir la foi des catholiques francophones. Privée de moyens, elle déclina au XVIIIe siècle et disparut sans bruit avec la Révolution, non sans avoir marqué durant plus d’un siècle la vie religieuse strasbourgeoise.
Recherches sur le Magistrat du Rhin
Authors: Descombes René 
Published: October 2012

Le Magistrat du Rhin, une institution de Napoléon Ier, siégeant à Strasbourg, a été créé par le décret du 27 octobre 1808 : il était « chargé de l’examen et de la décision de toutes les questions relatives à la conservation de la rive gauche du Rhin, depuis Huningue jusqu’à la frontière du royaume de Hollande ». Jean François Merlet, ancien Préfet de la Vendée, fut président du Magistrat du Rhin de 1809 à 1812. Rentrant en Vendée, il embarqua les archives du Magistrat du Rhin, dont on devait longtemps perdre la trace…Ces « Recherches sur le Magistrat du Rhin », basées en partie sur ces archives retrouvées, permettent d’avoir une vue d’ensemble sur cette institution, qui fonctionna de 1809 jusqu’à la chute du Premier Empire (1814), et « produisit d’excellents résultats, surtout relativement à l’entente entre les administrations des deux rives » (M. Coumes). On suivra avec intérêt les avatars du Président Merlet, qui n’a vraiment pas été à son aise à Strasbourg, mais qui, prenant à cœur ses attributions, poursuivit sa tâche avec zèle et compétence sans relâche, prenant ainsi part aux « affaires » du Strasbourg impérial. Ce « Magistrat du Rhin » est l’ancêtre direct de la « Commission Centrale pour la Navigation du Rhin », une création du congrès de Vienne (1815).
Faire connaître Liszt en son temps : Alfred et Marie Jaëll, « passeurs » oubliés
Authors: Ingelaere Marie-Laure 
Published: October 2012

La carrière des pianistes Alfred et Marie Jaëll a été largement influencée par Franz Liszt dont ils ont été les disciples d’une manière ou d’une autre. Mais Liszt leur est aussi redevable. Le virtuose Alfred Jaëll (1832-1882) a mis les œuvres de Liszt très tôt à son répertoire, dès les années 1855 et a contribué de plus à diffuser sa musique par le biais des « paraphrases » qu’il composait. Marie Jaëll-Trautmann (1846-1925), son épouse, s’imposera toute sa vie comme interprète incontestée de Liszt. Le cycle de six concerts qu’elle consacre en 1892 à Paris aux œuvres pour piano connues de Liszt marque son temps. L’étude des relations entre Liszt et Marie Jaëll éclaire la personnalité de cette dernière en tant que virtuose et compositrice et aussi en tant qu’initiatrice d’une nouvelle méthode pianistique basée sur une approche scientifique.
Le choc d’« Avant l’Oubli » de Philippe Avril et Gisèle Rapp-Meichler (1986, 1988)
Authors: Igersheim François 
Published: October 2012

Les associations de « Malgré-Nous » obtiennent par un accord franco-allemand du 31 mars 1981, l’indemnisation des « incorporés de force alsaciens et mosellans », qui sera effectivement appliquée en 1984. Des initiatives sont prises au début des années 80, par de jeunes historiens, journalistes et documentaristes alsaciens qui ont pour but de mettre en lumière ce drame, « nœud traumatique prégnant », qui marque l’opinion alsacienne de la fin du XXe siècle. Parmi eux celle de Philippe Avril et Gisèle Rapp‑Meichler. À partir de 1983, ils montent le projet qui prendra le nom « Avant l’oubli ». Ils réunissent plus de 200 heures d’entretien filmés, auxquels s’ajoutent 60 heures d’images d’actualité. Le tout est monté dans 3 épisodes de 30 et 40 minutes d’un film intitulé « Alsace, prise de guerre », diffusé en novembre 1986. Le film fait une impression profonde dans la population alsacienne : les générations d’après-guerre découvrent le drame des « Malgré-Nous ». Les entretiens sont pour la majorité menés en alsacien, sous-titré français, et à cette époque-là, la majorité de la population alsacienne comprend suffisamment l’alsacien pour être saisi par l’émotion des récits simples des témoins. Cette projection est suivie en 1988, d’une série d’expositions, à Mulhouse, Strasbourg, Forbach, Metz, Colmar. Même si des questions de droits d’auteurs, a définitivement cantonnée l’œuvre dans les archives de l’Institut national français de l’audiovisuel (INA) d’où il n’est jamais ressorti ce qui est regrettable, l’opération « Avant l’oubli » est un précurseur de l’entreprise du Mémorial de Schirmeck, lancé en 1993 et en 1999.
Les historiens anglophones et l’Alsace : une fascination durable
Authors: Carrol Alison 
Published: October 2012

L’Alsace est la région française la plus étudiée par les historiens anglophones. Cet article situe l’attention durable des chercheurs anglo-saxons dans une série de questions politiques et théoriques contemporaines : débats sur le régionalisme et la diversité de la France, questions de la construction des nations modernes et des identités nationales, discussions sur le rôle des frontières, et des régions frontalières dans l’Europe contemporaine et un mouvement intellectuel plus large qui vise à écrire l’histoire française de la perspective ‘transnationale.’ Cette historiographie anglophone a produit des résultats significatifs, notamment, il a montré la centralité de l’Alsace dans l’histoire nationale et européenne. Pourtant, en réintégrant l’histoire alsacienne dans les questions générales, les chercheurs anglo-saxons risquent adopter l’approche des administrateurs parisiens ou berlinois vis-à-vis de l’Alsace.
Les élections présidentielles et législatives du printemps 2012 en Alsace
Authors: Kleinschmager Richard 
Published: October 2012

Les élections présidentielles et législatives du printemps de 2012 ont confirmé l’ancrage à droite de l’Alsace, à contre-courant du changement national de majorité. Aux élections présidentielles, Nicolas Sarkozy a confirmé sa première place de 2007 dans la région et Marine Le Pen a reconquis l’influence perdue à l’élection présidentielle précédente par son père. François Hollande a stabilisé la présence du PS tandis que François Bayrou a perdu une part significative de son électorat. Aux élections législatives, dans le souffle de la victoire présidentielle de François Hollande, le PS a obtenu un deuxième député sur les quinze députés de la région dont l’écrasante majorité se rattachent à l’UMP. Le PS consolide ses positions dans les principales villes, en particulier Strasbourg qui compte désormais deux députés se réclamant de la nouvelle majorité présidentielle socialiste. Ces élections ont marqué un certain renouvellement de génération dans la représentation parlementaire du Bas‑Rhin dont cinq députés sur neuf se sont fait élire pour la première fois contrairement au Haut‑Rhin dont tous les députés élus sont des sortants.
APRIL Binding to BCMA Activates a JNK2–FOXO3–GADD45 Pathway and Induces a G2/M Cell Growth Arrest in Liver Cells
Authors: Notas George , Alexaki Vassilia-Ismini , Kampa Marilena , Pelekanou Vassiliki , Charalampopoulos Ioannis , Sabour-Alaoui Sanaa , Pediaditakis Iosif , Dessirier Valérie , Gravanis Achille , Stathopoulos Efstathios N. , Tsapis Andreas , Castanas Elias 
Published: October 2012

Abstract
The TNF superfamily ligands APRIL and BAFF bind with different affinity to two receptors, BCMA and TACI, and induce cell survival and/or proliferation, whereas BAFF also binds specifically to BAFFR. These molecules were considered specific for the immune system. Recently, however, they were also found in epithelial and mesenchymal noncancerous and cancerous tissues and cell lines. In this article, we report that hepatocellular carcinoma (HCC) cell lines HepG2 and Hep3B and HCC specimens express APRIL and BAFF and their receptors BCMA and BAFFR, but not TACI; APRIL/BCMA is enhanced in HCC, compared with normal liver tissue. In contrast to previous reports, APRIL binding to BCMA decreases cell proliferation by inducing G2/M cell cycle arrest, whereas BAFF has no effect on cell growth. HCC cells therefore represent a rare system in which these two ligands (APRIL and BAFF) exert a differential effect and may serve as a model for specific APRIL/BCMA actions. We show that the effect of APRIL is mediated via BCMA, which does not activate the classical NF-κB pathway, whereas it induces a novel signaling pathway, which involves JNK2 phosphorylation, FOXO3A activation, and GADD45 transcription. In addition, JNK2 mediates the phosphorylation of Akt, which is activated but does not participate in the antiproliferative effect of APRIL. Furthermore, transcriptome analysis revealed that APRIL modifies genes specifically related to cell cycle modulation, including MCM2/4/5/6, CDC6, PCNA, and POLE2. Our data, therefore, identify a novel APRIL/BCMA signaling pathway in HCC and suggest that APRIL could have a pleiotropic role in tumor biology.
Mouse Clr-g, a Ligand for NK Cell Activation Receptor NKR-P1F: Crystal Structure and Biophysical Properties
Authors: Skálová Tereza , Kotýnková Kristýna , Dušková Jarmila , Hašek Jindřich , Kovaǐ Tomáš , Kolenko Petr , Novák Petr , Man Petr , Hanč Pavel , Vaněk Ondřej , Bezouška Karel , Dohnálek Jan 
Published: October 2012

AbstractInteractions between C-type lectin-like NK cell receptors and their protein ligands form one of the key recognition mechanisms of the innate immune system that is involved in the elimination of cells that have been malignantly transformed, virally infected, or stressed by chemotherapy or other factors. We determined an x-ray structure for the extracellular domain of mouse C-type lectin related (Clr) protein g, a ligand for the activation receptor NKR-P1F. Clr-g forms dimers in the crystal structure resembling those of human CD69. This newly reported structure, together with the previously determined structure of mouse receptor NKR-P1A, allowed the modeling and calculations of electrostatic profiles for other closely related receptors and ligands. Despite the high similarity among Clr-g, Clr-b, and human CD69, these molecules have fundamentally different electrostatics, with distinct polarization of Clr-g. The electrostatic profile of NKR-P1F is complementary to that of Clr-g, which suggests a plausible interaction mechanism based on contacts between surface sites of opposite potential.
Specific Serum Ig Recognizing Staphylococcal Wall Teichoic Acid Induces Complement-Mediated Opsonophagocytosis against Staphylococcus aureus
Authors: Jung Dong-Jun , An Jang-Hyun , Kurokawa Kenji , Jung Yoon-Chuel , Kim Min-Jung , Aoyagi Youko , Matsushita Misao , Takahashi Shinji , Lee Hee-Seung , Takahashi Kazue , Lee Bok Luel 
Published: October 2012

Abstract
Wall teichoic acid (WTA) of Staphylococcus aureus is a major cell envelope-associated glycopolymer that is a key molecule in promoting colonization during S. aureus infection. The complement system plays a key role in the opsonization and clearance of pathogens. We recently reported that S. aureus WTA functions as a ligand of human serum mannose-binding lectin (MBL), a recognition molecule of the lectin complement pathway. Intriguingly, serum MBL in adults does not bind to WTA because of an inhibitory effect of serum anti–WTA-IgG. In this study, serum anti–WTA-IgG was purified to homogeneity using a purified S. aureus WTA-coupled affinity column to examine the biological function of human anti–WTA-IgG. The purified anti–WTA-IgG contained the IgG2 subclass as a major component and specifically induced C4 and C3 deposition on the S. aureus surface in the anti–WTA-IgG–depleted serum, but not in C1q-deficient serum. Furthermore, the anti–WTA-IgG–dependent C3 deposition induced phagocytosis of S. aureus cells by human polymorphonuclear leukocytes. These results demonstrate that serum anti–WTA-IgG is a real trigger for the induction of classical complement-dependent opsonophagocytosis against S. aureus. Our results also support the fact that a lack of the lectin complement pathway in MBL-deficient adults is compensated by Ag-specific, Ab-mediated adaptive immunity.
Yersinia enterocolitica YadA Mediates Complement Evasion by Recruitment and Inactivation of C3 Products
Authors: Schindler Magnus K. H. , Schütz Monika S. , Mühlenkamp Melanie C. , Rooijakkers Suzan H. M. , Hallström Teresia , Zipfel Peter F. , Autenrieth Ingo B. 
Published: October 2012

Abstract
Yersinia adhesin A (YadA) is a major virulence factor of Yersinia enterocolitica. YadA mediates host cell binding and autoaggregation and protects the pathogen from killing by the complement system. Previous studies demonstrated that YadA is the most important single factor mediating serum resistance of Y. enterocolitica, presumably by binding C4b binding protein (C4BP) and factor H, which are both complement inhibitors. Factor H acts as a cofactor for factor I-mediated cleavage of C3b into the inactive form iC3b and thus prevents formation of inflammatory effector compounds and the terminal complement complex. In this study, we challenged the current direct binding model of factor H to YadA and show that Y. enterocolitica YadA recruits C3b and iC3b directly, without the need of an active complement cascade or additional serum factors. Enhanced binding of C3b does not decrease survival of YadA-expressing Yersiniae because C3b becomes readily inactivated by factor H and factor I. Binding of factor H to YadA is greatly reduced in the absence of C3. Experiments using Yersinia lacking YadA or expressing YadA with reduced trimeric stability clearly demonstrate that both the presence and full trimeric stability of YadA are essential for complement resistance. A novel mechanism of factor H binding is presented in which YadA exploits recruitment of C3b or iC3b to attract large amounts of factor H. As a consequence, formation of the terminal complement complex is limited and bacterial survival is enhanced. These findings add a new aspect of how Y. enterocolitica effectively evades the host complement system.
Laparoscopic Nephrectomy Treatment of Renal Tumors over 7 cm: Our Experience
Authors: Montisci Erica , Corona Andrea , Serra Simona , De Lisa Antonello 
Published: October 2012

Introduction Radical nephrectomy by open surgery is the gold standard treatment for localized renal cancers. Several studies can demonstrate the efficacy and safety of laparoscopic radical nephrectomy for tumors in stage T1. Materials and Methods From June 2004 to June 2011 we studied 132 patients undergoing videolaparoscopic radical nephrectomy, and analyzed the following parameters: cancer site, cancer dimension, eventual lymphadenectomy and surrenectomy approach used (transperitoneal or retroperitoneal), surgery time, pre- and post-surgery (24h) hemoglobin and creatinine. Patients were then divided in 2 groups: Group A (78 patients): T1 cancer (dimension less than 7 cm); Group B (54 patients): T2–T3 cancer (dimension equal or larger than 7 cm) (T2 = 62%; T3 = 38%). Results There were no significant statistic differences between the 2 groups about number of patients, decrease of hemoglobin and increase of creatinine. On the other side, significant differences were found about surgery time: 127 min for Group A against 170 min for Group B. Conclusions Laparoscopic radical nephrectomy shows a lower morbidity compared to open surgery, although this is confirmed by a few studies; cancer controls seem equivalent between the T1 and T2 tumors. Radical nephrectomy by laparoscopy was and is still recommended for T1 and T2 cancers, but there is no enough evidence that it can be useful in the same way for T3 cases. Our study supports the thesis that laparoscopic radical nephrectomy is a safe and effective approach for tumors at and above 7 cm and not just those smaller, with an equal number of complications compared to an increase in the average surgery time.
Optimal Pricing and Coordination Schemes for the Eastern Route of the South‐to‐North Water Diversion Supply Chain System in China
Authors: Wang Huimin , Chen Zhisong , Ivan Su Shong‐Iee 
Published: October 2012

AbstractThe Eastern Route of the South‐to‐North Water Diversion (SNWD‐ER) project in China is a highly complex interbasin water‐diversion system, which is constructed to pump, store, and supply water to support the rational water redistribution in China. This article presents the optimization modeling approach for the pricing and coordinating schemes of SNWD‐ER project, and discusses the analysis results and their policy implications on the pricing and coordinating mechanisms in the SNWD‐ER water‐resource supply chain. For the government, formulating reasonable retail price upper bound is important to control the water resource wholesale price and retail price. Besides, various water‐saving mechanisms can increase the price elasticity of water demand and affect the wholesale and retail prices. For the corporations, increasing the water resource production capacity and its supply will decrease the wholesale and retail prices. Furthermore, keeping enough initial water resource inventory by enhancing the rainfall using rate, and using ‘free supply sources’‐rainfall, or even some flooding sources can effectively decrease the wholesale and retail prices. Finally, for the end‐users, enhancing the rainfall using rate can effectively decrease the wholesale and retail prices and reduce the energy consumption, which is good for the sustainable development and a low‐carbon economy.
<b> Escolha profissional na perspectiva de professores de educação infantil </b>
Authors: Brasil Ive Carina Rodrigues Lima , Galvão Afonso Celso Tanus 
Published: October 2012

http://dx.doi.org/10.5902/198464442530 Esta pesquisa qualitativa e exploratória teve por objetivo investigar os motivos subjacentes à escolha profissional de professores que atuam na educação infantil. Foram entrevistados 17 professores (07 de escolas públicas e 10 de escolas particulares) a partir de um roteiro semiestruturado que tinha por base a pergunta: que motivos orientaram a sua escolha profissional? Resultados sugerem que os motivos que nortearam a escolha dos professores pelo trabalho na educação infantil foram associados ao fato de gostar de criança, à influência familiar, oportunidade, idealismo, encantamento e talento entre outras coisas. Parte dos professores entrevistados passou a atuar na educação infantil por escolha consciente, enquanto que outros foram levados meramente pelas circunstâncias. As conseqüências desse discurso para fortalecimento de noções estereotipadas da profissão (maternagem, profissão feminina) são abordadas na discussão.
<b> Quem é seu melhor professor universitário e por quê? características do bom professor universitário sob o olhar de licenciandos </b>
Authors: Pachane Graziela Giusti 
Published: October 2012

http://dx.doi.org/10.5902/198464442926 A presente pesquisa objetiva analisar a percepção de alunos de diferentes cursos de licenciatura de uma universidade de Minas Gerais a respeito das características do bom professor universitário. Conduzida a partir de dados levantados para elaboração de um trabalho de conclusão de uma disciplina de graduação, o estudo foi ampliado e incorporado a um projeto mais amplo, que visa analisar questões relativas à pedagogia universitária. Tendo por base estudos realizados por pesquisadores nacionais e internacionais acerca da formação pedagógica e do trabalho do professor universitário, foram analisados os dados obtidos a partir do questionário criado para conhecer quem eram os melhores professores na visão dos licenciandos e por que razão eles se distinguiam. Os resultados apontam para a importância da didática, do bom relacionamento pessoal com os alunos, do domínio aprofundado do conteúdo, das habilidades de comunicação e da preocupação com a aprendizagem dos estudantes como os fatores que se sobressaem na caracterização dos bons professores universitários, segundo a percepção destes licenciandos. Abrem, ainda, oportunidade a uma série de questionamentos, muitos deles acerca do papel desses professores, por sua vez formadores de formadores.
<b>A infância em face do desenvolvimento tecnológico: um estudo das representações sociais de criança</b>
Authors: Bona Viviane De , Maia Licia De Souza Leão 
Published: October 2012

http://dx.doi.org/10.5902/198464443107 A pesquisa que deu origem a este trabalho buscou compreender o sentido atribuído à infância em um mundo habitado pelas tecnologias da informação, em especial as digitais. O presente artigo propõe a análise das representações sociais de criança compartilhadas por 200 professores da rede pública de ensino do Recife(PE) com o intuito de entender o significado social da palavra criança, veiculado e usado como sistema de referência que guia as pessoas nos seus relacionamentos com esse grupo de sujeitos. Para tanto, foram utilizados testes de associação livre como instrumentos de coleta de dados. Com o apoio do software Trideux e da Análise de Conteúdo, foram feitas as análises das associações. Os resultados da pesquisa apontam alguns aspectos que parecem se perpetuar em relação à definição do ser criança, tais como: brincar, ir para a escola e possuir bons sentimentos. Em relação à tecnologia, evidenciam-se a dimensão lúdica e formativa desses recursos. Palavras-chave: criança; tecnologias; representações sociais.
<b>“É a lei”: o Ensino Fundamental de 9 anos da perspectiva de graduandas/o de Pedagogia</b>
Authors: Rocha Maria Silvia P. de M. L. da 
Published: October 2012

http://dx.doi.org/10.5902/198464444069 Trata-se dos resultados de pesquisa qualitativa delineada com objetivo geral de identificar concepções de graduandas/o de um curso de Pedagogia sobre o novo Ensino Fundamental de 9 anos (EF). Os procedimentos metodológicos utilizados foram a produção de um texto sobre o EF e entrevistas semiestru-turadas. Neste artigo, focalizam-se os resultados obtidos pela produção de textos. Dela, participaram 33 graduandos de Pedagogia de uma universidade privada do interior de São Paulo, concluintes desta graduação em 2010. O material empírico foi analisado através de categorias construídas a posteriori, pela leitura intensiva do material, buscando núcleos temáticos recorrentes nas produções, interpretados à luz da teoria histórico-cultural. Dos resultados, destacam-se concepções essencialmente positivas do novo EF, menções quanto à importância de preparo dos professores e das escolas e abordagem incipiente da atividade lúdica (predominando um tratamento genérico da mesma). Esses resultados permitem localizar pontos importantes de serem abordados na formação inicial e continuada dos professores que trabalham e trabalharão na construção do novo EF e problematizar o modo pelo qual graduandas/o de Pedagogia interpretam o estatuto das leis no campo da educação. Palavras-chave: Ensino Fundamental de 9 anos; atividade lúdica; formação inicial de professores.