bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective cohort study on rivaroxaban in the prevention of catheter-related thrombosis in breast cancer.
Authors: Sang Die , Zhang Yurong , Fan Shanmin , Li Shiyu , Su Yanfang , Yuan Peng 
Published: August 2024

e12602 Background: Chemotherapy is an important treatment strategy for breast cancer. Catheter related thrombosis (CRT) is one of the most common complications of catheterization, affecting patients’ living quality and survival. It is thus of great practical significance for exploring how to prevent CRT. That’s why we carried out this study to provide evidence-based medical data for the prevention and treatment of thrombosis in breast cancer patients. Methods: A prospective cohort study approach was adopted. Breast cancer patients who received deep vein catheterization chemotherapy from July 2021 to July 2023 were selected. Cohort A included patients in the treatment group: they received prophylactic anticoagulation after catheterization: Rivaroxaban, 10 mg, orally once/d for 2 months; cohort B included patients in the control group, who did not receive prophylactic anticoagulation. The thrombosis was compared between the patients in the two groups within six months after catheterization. The comparison between groups was tested by X2 test, and logistic regression analysis was used to analyze the influencing factors of CRT. Results: A total of 402 breast cancer patients were enrolled. The incidence of CRT was 2.0% (4/201) in the treatment group of 201 cases and 12.4% (25/201) in the control group of 201 cases ( P=0.000). The thrombus was mainly located around the axillary vein, basilic vein and subclavian vein, the innominate vein, and the internal jugular vein. There were 44.8% (13/29) patients developed CRT within 30 days after catheterization, 20.7% (6/29) patients developed CRT within 30~<60days, and 34.5% (10/29) patients developed CRT within 60~<120 days. Patients diagnosed with CRT received anticoagulant therapy for 3 months. Within three months, the thrombus regression rate reached 100.0% (29/29). Univariate analysis showed that whether to receive prophylactic anticoagulation, whether hemoglobin is normal, patients whether to experience previous endocrine therapy, different Age group and chemotherapy regimens were actors for thrombosis, P<0.05 respectively. Multivariate analysis indicated that age and whether to receive prophylactic anticoagulation were independent factors for thrombosis ( P=0.019, P=0.006, respectively). Patients diagnosed with CRT received deep vein cannulation while anticoagulation therapy was administered, with smooth infusion. They all completed antitumor therapy as planned, and no abnormalities such as new thrombosis and pulmonary embolism were found. Conclusions: The prophylactic anticoagulation regimen with Rivaroxaban can reduce the incidence of CRT in breast cancer, showing good efficacy and safety. Therefore, medical staff should carry out early prevention, early detection and early treatment for CRT to improve the living quality of patients. Clinical trial information: ChiCTR2000031649.
Efficacy and safety of neoadjuvant trastuzumab, pyrotinib, and dalpiciclib without chemotherapy in early-stage HR-negative/HER2-positive breast cancer: An open-label, single-arm phase II trial.
Authors: Zhi Xiao , Chen Feiyu , Liao Liqiu , Luo Shayang , Liu Xuan , Liu Xiangyan , Xu Tao , Hu Yu , Luo Na , Wang Kuansong , Wang Shouman 
Published: August 2024

e12613 Background: The chemotherapy-free neoadjuvant regimens of dual HER2 blockade has showed encouraging rates of pathological complete response (pCR) in patients with HER2-positive breast cancer. Additionally, combining cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors with anti-HER2 therapy has shown synergistic effects in hormone receptor (HR)-positive and HER2-positive breast cancer. However, there is limited data regarding this combination strategy in HR-negative/HER2-positive settings. The objective of this study was to evaluate the efficacy and safety of a chemotherapy-free regimen consisting of the CDK4/6 inhibitor dalpiciclib, and dual anti-HER2 components of pyrotinib and trastuzumab in patients with HR-negative/HER2-positive early breast cancer (EBC). Methods: This open-label, single-arm, phase II study was designed using the Simon two-stage method (Registration number: Chi-CTR-2200060748). Patients with HR-negative/HER2-positive operable EBC (tumor stage T1-3 and nodal stage N0-2) were enrolled. Eligible patients received trastuzumab (HLX02, 8 mg/kg loading dose, followed by 6 mg/kg every 3 weeks intravenously) for 15 weeks, plus pyrotinib (240 mg daily orally) and dalpiciclib (125 mg daily orally for 3 weeks, followed by 1 week off) for 16 weeks. Surgery was performed 3-6 weeks after the completion of the last cycle of study treatment. The primary endpoint was pCR (ypT0/Tis ypN0) at surgery, and secondary endpoints included objective response rate (ORR), change of Ki-67 labeling index, biomarker analysis, survival and safety. Results: Between Jun 24, 2022, and Sept 14, 2023, a total of 30 patients with a median age of 54.5 years (range: 35-66) were enrolled and treated in this ongoing trial. As of the data cutoff date on Jan 20, 2024, 26 patients underwent surgery, and pCR was achieved in 18 (69.2%) cases. Out of the 29 patients with evaluable response, 26 achieved partial response and 3 achieved stable disease, resulting in an ORR of 89.7%. The most common grade 3 or more treatment-related adverse events (AEs) were diarrhea (66.7%), decreased neutrophil count (33.3%), and decreased white blood cell count (20.8%). Most AEs were tolerable, and no treatment-related deaths occur. Conclusions: In patients with HR-negative/HER2-positive EBC, a dual HER2-targeted combination of pyrotinib and trastuzumab, along with dalpiciclib in the absence of chemotherapy showed promising efficacy with encouraging pCR and ORR rates, as well as a favorable safety profile in the neoadjuvant setting. Clinical trial information: Chi-CTR-2200060748.
Results of a phase 1/2 study of MHB036C: A potential best-in-class TROP2 antibody-drug conjugate (ADC) incorporating a potent DNA topoisomerase I inhibitor in locally advanced or metastatic solid tumors.
Authors: Lu Shun , Zhang Qingyuan , Meng Xiangjiao , Sun Yuping , Xiong Hui Hua , Lv Dongqing , Wang Xiaojia , Wu Lin , Dong Xiaorong , Ji Yuanyuan , Ji Yinghua , Han Liang , Lei Kaijian , Jiang Ou , Zhao Yanqiu , Zhang Zhen , Shi Junwei , Cao Guoqing 
Published: August 2024

e15007 Background: MHB036C, an investigational ADC, comprises a humanized anti-TROP2 monoclonal antibody engineered to minimize potential toxicities mediated by non-specific uptake, and a highly potent DNA topoisomerase I inhibitor (5~10 times more potent than DXd) conjugated via a stable cleavable linker. In preclinical studies, MHB036C demonstrated superior tumor killing activities (5~10 times more potent than the DS-1062a analog) and a favorable safety profile with no unique toxicities as compared to other TROP2 ADCs and no occurrences of interstitial lung disease (ILD). We here present the safety and efficacy results from a first-in-human phase 1/2 study of MHB036C. Methods: Patients with locally advanced or metastatic solid tumors were enrolled in dose-escalation (D-Esc) and dose-expansion (D-Exp) segments. The D-esc study, utilizing an accelerated titration followed by the traditional 3+3 design, assessed MHB036C at doses ranging from 0.25-2.25 mg/kg administered intravenously (IV) every 3 weeks. Results: At data cutoff (Dec 31, 2023), 26 pts were enrolled and received at least one dose of MHB036C (D-Esc, n=11, D-Exp, n=15). Two pts experienced dose-limiting toxicities (Grade 3 stomatitis) at 2.25 mg/kg. The MTD was determined to be 1.5 mg/kg. The most common TRAEs overall in ≥25% of pts were stomatitis, anemia, decreased appetite, vomiting, white blood cell (WBC) count decreased, fatigue, nausea, and neutrophil count decreased. The most common Grade ≥3 TRAEs (occurred in ≥5% of pts) were stomatitis (34.6%), WBC count decreased (11.5%), neutrophil count decreased (7.7%), and anemia (7.7%). No ILD was reported. Of 21 response-evaluable pts, 7 experienced partial responses. In the subset of 12 NSCLC pts treated with doses ranging from 1.3 to 2.25 mg/kg, the ORR was 33.3% (4/12) and the DCR was 83.3%. In the subset of 5 HER2-negative breast cancer pts encompassing 4 TNBC pts and 1 HR+/HER2- breast cancer patient, the ORR was 60.0% (3/5). Conclusions: MHB036C demonstrated a manageable safety profile without either major hematologic side effects or ILDs and encouraging efficacy in NSCLC and HER2- breast cancer, representing a potential best-in-class TROP2 ADC. The dose optimization and expansion study is ongoing to establish the RP2D for MHB036C. Clinical trial information: CTR20231246.
World War II and Socialist Integration: In Search of the Theoretical Foundations for Building the Socialist Bloc (1940–64)
Authors: Nenovsky Nikolay , Marinova Tsvetelina 
Published: August 2024

Abstract
This article presents the development of ideas on coordination between countries with socialist economic systems during World War II and in its immediate aftermath (1940–64). It studies the theoretical models of Hoselitz and the debates on the possibilities of interaction between socialist states after the war, as well as the first attempts to develop integration within the framework of the CMEA, or the Council for Mutual Economic Assistance, in practice. The lack of a clear theory made these processes difficult. Yugoslav economists considered nonequivalent exchange within the Marxist paradigm and attempts to create a monetary zone of the ruble encountered difficulties from the outset. Monetary reforms in socialist countries showed the need to adapt to the world (capitalist) market.
Economic Expertise at War: A Brief History of the Institutionalization of French Economic Expertise (1936–46)
Authors: Caldari Katia , Legrand Muriel Dal Pont 
Published: August 2024

Abstract
French economic expertise developed significantly during the interwar period when economic issues, and particularly those resulting directly from World War I, became the overriding concern for Europe's democracies. Before the end of World War II, three major institutes of conjuncture had been created, all of them driven by the need for economic policy indicators. ISRES was established in 1933 by Charles Rist, the Institut Français de la Conjoncture was founded in 1938 by Alfred Sauvy, and ISEA was founded in 1944 by François Perroux. Not surprisingly, all three were working on productivity measures. From 1936, debate was focused on the issue of the forty-hour week and then moved to the context of the arms race and the preparation for an inevitable war. The war period resulted in shortages that required planning of production; and in the postwar period the focus was on plans for the reconstruction of France and then Europe more generally. All these periods generated demand for differentiated economic expertise in productivity. In 1946, the first French National Accounts were published alongside the establishment of the Commissariat Général au Plan and INSEE, which resulted in another distinct period.
World War II and Industrialization Policies in Latin America: The Cases of Argentina and Brazil
Authors: Calcagno Adriana , Duarte Pedro Garcia 
Published: August 2024

Abstract
Raúl Prebisch and Celso Furtado were two important contributors to development economics and to the theories and policies defended by the United Nations Economic Commission for Latin America (ECLAC). In this article, we argue that understanding their ideas, and how industrialization became a key concern, requires paying closer attention to the geopolitical changes brought by World War II. We discuss how Argentina and Brazil, their home countries, navigated the troubled waters brought by the war and the international trade disruptions and turned state-led industrialization into a key development strategy. After the war, the United States became the new hegemonic power and adopted a universalist foreign policy, based on the newly created international agencies. At home, the internationalist businessmen promoted the partnership capitalism that became central to the foreign policy during the Truman administration and onward, making industrialization a key interest. Internationalism was also what Latin American countries used to counteract the US hegemony even before the war, which culminated in the creation of ECLAC after the war. The intellectual paths of Prebisch and Furtado toward industrialization policies were shaped by the changing international order and by local developments in their countries including the building of a more scientific statistical system that would better help the state to design development policies.
Economic Responses to Nazi Aggression in Europe: Albert Hirschman and Paul Rosenstein-Rodan on the Economic Sovereignty of Central and Eastern Europe
Authors: Alacevich Michele 
Published: August 2024

Abstract
Germany's expansion in Central and Eastern Europe was not just one among many aggressive moves by the Third Reich but the central strategy of the Nazi imperial project on the continent. Prominent economists, politicians, and think tanks agreed that crucial to this project was Germany's economic domination of the area, and they committed to developing a new vision for a postwar international order that avoided the instability and turmoil of the interwar years. This article discusses the analyses of the crisis of Central and Eastern Europe and solutions to it that Albert Hirschman and Paul Rosenstein-Rodan, then both virtually unknown and working independently one from the other, produced during World War II—Hirschman with a focus on the international dimension and Rosenstein-Rodan with a focus on the domestic one. This article offers a synthetic discussion of how the war deeply affected their economic thinking and how, in turn, their analyses became foundational elements of new and important disciplinary fields in the postwar decades, such as international political economy and development economics.
Forgettable Black and Amazigh Bodies
Authors: El Guabli Brahim 
Published: August 2024

Abstract
Boujemâa Hebaz (1943–1981), a Black and Amazigh professor at Mohammed V University, was forcibly disappeared in 1981. This article reads the irresolution of his case against the background of exclusion and amnesia that surrounds the fate of Black and Amazigh people in southeast/southwest Morocco. I argue that Hebaz's case reflects a wider history of absence, disappearance, and discrimination that impacts Black Amazigh Moroccans. Hebaz straddled identities that were simply disregarded throughout the Years of Lead (1956–1999). When the Moroccan police kidnapped Hebaz in April 1981, they were aware that he was from the southeast, an area that is not only predominantly Amazigh and Black but a region that had already been turned into a large prison for political detainees. The presence of several notorious secret prisons further exacerbated the region's territorial marginalization and disconnection from the rest of Morocco. This fact would later be officially acknowledged in the final Equity and Reconciliation Commission's (ERC) report and recommendations. Drawing on interviews, authentic materials, ERC reports, and other sources, the article demonstrates how Hebaz's absence is enmeshed in racism, territorial marginalization, and historical amnesia in Morocco.
Empowering the “Ecosystem”
Authors: Tobias Zak 
Published: August 2024

Abstract
This article draws upon original research including a series of interviews, extensive desk research, and a canon of political economy scholarship hailing from Lebanon and elsewhere to explore the political dynamics underpinning Lebanon's emerging tech “ecosystem.” It focuses on a seemingly peripheral actor within this ecosystem, the coding school, both as a window into the ecosystem's political machinery and as a surprisingly important site through which its wider interests are mediated. This focus explores how the coding school generates so-called empowerment conceived largely in terms of training and preparing Lebanon's “underprivileged youth” for global tech markets, through a strategic alignment with the ecosystem. Thus, empowerment becomes a political currency of sorts, helping to reify and repackage an enclave of Lebanon's economy. The article suggests that the political work to engineer this new economic landscape reflects how state-business interests come together to repackage so-called development and enforce new regimes of accumulation at a time of deepening crisis.
Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma
Authors: Morshed Ramin A. , Nguyen Minh P. , Youngblood Mark W. , Perlow Haley K. , Lucas Calixto-Hope G. , Patel Akash J. , Palmer Joshua D. , Chandler James P. , Theodosopoulos Philip V. , Magill Stephen T. , Chen William C. , Raleigh David R. 
Published: August 2024

BACKGROUND AND OBJECTIVE:
Patients who undergo gross total resection (GTR) of Central Nervous System World Health Organization (WHO) grade 1 meningioma constitute a “low-risk” group, but some low-risk meningiomas can recur despite reassuring clinical and histological features. In this study, gene expression values in newly diagnosed WHO grade 1 meningiomas that had undergone GTR were evaluated for their association with recurrence.

METHODS:
This was a retrospective, international, multicenter cohort study that included WHO grade 1 meningiomas that underwent GTR, as first treatment, based on postoperative magnetic resonance imaging. Normalized gene expression values from a previously validated 34-gene panel were evaluated for their association with recurrence. Kaplan-Meier, multivariable Cox proportional hazard analyses, and K-means clustering were performed to assess the association of genes of interest with recurrence and identify molecular subgroups among clinically and histologically low-risk meningiomas.

RESULTS:
In total, 442 patients with WHO grade 1 meningiomas that underwent GTR and had available gene expression profiling data were included in the study. The median follow-up was 5.0 years (interquartile range 2.6-7.7 years), local recurrence occurred in 36 patients (8.1%), 5-year local freedom from recurrence was 90.5%, and median time to recurrence was 2.9 years (range 0.5-10.7 years). Eleven genes were associated with local recurrence, including lower expression of ARID1B, ESR1, LINC02593, PGR, and TMEM30B and higher expression of CDK6, CDKN2C, CKS2, KIF20A, PGK1, and TAGLN. Of these genes, PGK1 had the largest effect size. K-means clustering based on these 11 genes distinguished 2 molecular groups of clinically and histologically low-risk meningiomas with significant differences in local freedom from recurrence (hazard ratio 2.5, 95% CI 1.2-5.1, P = .016).

CONCLUSION:
Gene expression profiling may help to identify newly diagnosed WHO grade 1 meningiomas that have an elevated risk of recurrence despite GTR.
Realizing Textbook Outcomes Following Liver Resection for Hepatic Neoplasms with Development and Validation of a Predictive Nomogram
Authors: Gundavda Kaival K. , Patkar Shraddha , Kannan Sadhana , Varty Gurudutt P. , Nandy Kunal , Shah Tanvi , Polusany Kaushik , Solanki Sohan Lal , Kulkarni Suyash , Shetty Nitin , Gala Kunal , Ostwal Vikas , Ramaswamy Anant , Bhargava Prabhat , Goel Mahesh 
Published: August 2024

Abstract
Background
‘Textbook Outcome’ (TO) represents an effort to define a standardized, composite quality benchmark based on intraoperative and postoperative endpoints. This study aimed to assess the applicability of TO as an outcome measure following liver resection for hepatic neoplasms from a low- to middle-income economy and determine its impact on long-term survival. Based on identified perioperative predictors, we developed and validated a nomogram-based scoring and risk stratification system.

Methods
We retrospectively analyzed patients undergoing curative resections for hepatic neoplasms between 2012 and 2023. Rates of TO were assessed over time and factors associated with achieving a TO were evaluated. Using stepwise regression, a prediction nomogram for achieving TO was established based on perioperative risk factors.

Results
Of the 1018 consecutive patients who underwent liver resections, a TO was achieved in 64.9% (661/1018). The factor most responsible for not achieving TO was significant post-hepatectomy liver failure (22%). Realization of TO was independently associated with improved overall and disease-free survival. On logistic regression, American Society of Anesthesiologists score of 2 (p = 0.0002), perihilar cholangiocarcinoma (p = 0.011), major hepatectomy (p = 0.0006), blood loss >1500 mL (p = 0.007), and presence of lymphovascular emboli on pathology (p = 0.026) were associated with the non-realization of TO. These independent risk factors were integrated into a nomogram prediction model with the predictive efficiency for TO (area under the curve 75.21%, 95% confidence interval 70.69–79.72%).

Conclusion
TO is a realizable outcome measure and should be adopted. We recommend the use of the nomogram proposed as a convenient tool for patient selection and prognosticating outcomes following hepatectomy.
Local anesthesia as an alternative to general anesthesia in ENT surgery – a review of selected procedures
Authors: Parfianowicz Agnieszka , Surma Alicja , Jaworski Arkadiusz , Grajnert Filip , Plizga Jakub , Głuszczyk Agnieszka , Cecot Jakub , Zarzecki Konrad , Mandryk Miłosz , Holdun Nazar 
Published: August 2024

Surgeries and procedures in otolaryngology require close collaboration between anesthesiologists and ENT specialists, especially for operations involving the larynx and airways, which pose challenges for maintaining airway patency and visibility. Choosing the type of anesthesia, whether general or local, is crucial. This study examines the benefits and drawbacks of both types of anesthesia in tonsillectomy and adenoidectomy, tympanostomy and myringotomy, and flexible endoscopic biopsy of the pharynx and larynx. A review of current guidelines, systematic reviews and relevant clinical cohort studies was conducted. The findings highlight several advantages of local anesthesia, including shorter operation times, reduced hospital stays, lower costs, decreased use of analgesics, and improved patient comfort.
Energy drinks: is there anything to be concerned about? A review of the literature with attention to the value of drinks among athletes
Authors: Witkowska Maria , Skotnicka Joanna , Błaszczak Karolina , Turek Monika , Jaroń Aleksandra , Jastrzębska Katarzyna , Wojciechowska Klara , Borkowski Adrian , Sawicki Mateusz 
Published: August 2024

Introduction:
Popular energy drinks containing caffeine, taurine or guarana are currently generating a lot of interest. Their supply is an increasingly popular method of boosting the body. Therefore, it is important to know the effects of such drinks on health.
Objective:
A review of the literature on the health effects of energy drinks with a focus on the value of their consumption in athletes.
Current Knowledge:
Many studies have been made and numerous medical cases have been analyzed to assess the health effects of energy drinks. The most commonly described complications are those involving the cardiovascular and neurological systems, but there are also cases of gastrointestinal, kidney, gynecological or skin diseases. The severity of these complications depends on the amount of energy drinks consumed and the time interval in which they were drunk. Nowadays, athletes are increasingly turning to energy drinks to boost their performance. It is also noticeable that children and adolescents who should not consume caffeine or sugar in excess consume this type of drink.
Conclusions:
The growing popularity of energy drinks, including among professional athletes as well as children and adolescents, is leading to an increasing number of complications due to their excessive consumption. Therefore, further research on their health effects and harmfulness is needed to determine their safe use.