bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory Linear Verrucose Epidermal Nevus Coexisting with Lichen Amyloidosus
Authors: Zhuang Lihua , Zhu Wenyuan 
Published: April 2015

AbstractThe clinical and histopathological findings in a case of inflammatory linear verrucose epidermal nevus coexisting with lichen amyloidosus are presented. A 33‐year‐old woman had had linear verrucose lesions which were histopathologically compatible with ILVEN, and with which no amyloid deposits were associated, on her left lower leg for 30 years. She had noticed keratotic papules around the verrucose lesions on the left leg for the last 3 years. Histopathology of these papules revealed amyloid deposits in the upper dermis under the hyperkeratotic and acanthotic epidermis. Topical application of DMSO liniment with dexamethasone successfully treated the ILVEN. This remission of both lesions and itching also alleviated the keratotic papules on the left leg.
Two Cases of Pachydermodactyly
Authors: Kim Tae‐Heung , Cho Yoon‐Hyang , Park Heung‐Bae 
Published: April 2015

AbstractWe report two cases of pachydermodactyly. Case 1 was a 16‐year‐old girl who complained of asymptomatic, bulbous, firm swellings which developed insidiously on both sides of the proximal interphalangeal (PIP) joint of her right middle finger. Case 2 was a 14‐year‐old boy with similar lesions on the sides of the PIP joints of the index and middle fingers of both hands. They both had histories of mild, repetitive mechanical trauma of the fingers.Radiologic findings showed soft tissue swellings without any bony or articular abnormalities. Histopathologic findings from the bulbous swellings revealed marked hyperkeratosis, slight epidermal hyperplasia, and a markedly thickened dermis with a deposition of mucinous material among the collagen fibers. Ultrastructural examinations of both cases showed decreased diameters of collagen fibrils. The lesions temporarily improved with intralesional injection of triamcinolone acetonide.Pachydermodactyly is more commonly found in boys and the affected fingers are more numerous in boys. Both of the present cases had the habit of rubbing and gripping their fingers unconsciously. Mechanical trauma of the fingers around puberty may play an important role in pachydermodactyly.
Multiple Milia Localized to the Vulva
Authors: Kanekura Takuro , Kanda Akira , Higo Akiko , Kanzaki Tamotsu 
Published: April 2015

AbstractMilia are most commonly observed on the cheeks and eyelids. We studied a case of multiple milia localized to the vulva in a 64‐year‐old female. A review of English and Japanese literature for the last 20 years failed to uncover any reports of milia limited to this area.We describe this case in detail and provide a short review of the literature on cysts of the genitalia.
Scleroedema in a Child
Authors: Mitsuhashi Yoshihiko , Kondo Shigeo , Shimizu Yukitoshi 
Published: April 2015

AbstractA 3‐year‐old Japanese girl with scleroedema was reported. She had had no signs of diabetes but did have a preceding bacterial infection in the tonsils three weeks before the skin lesion appeared. The skin on the face, shoulders, extensor aspect of the upper arms, and proximal half of the forearms was indurated. The skin lesions expanded from the middle part of the forearms to the wrists during the observation period. Thereafter, the induration gradually disappeared. A literature review revealed there were only six reports of scleroedema in children under 15 years old before 1996 in Japan; a total of 166 cases of the disease was reported in the same period. Five out of these six cases were not diabetes‐associated. All but one of these six patients were female. Juvenile scleroedema seems to be rare in Japan.
Human Leukocyte Interferon‐α in a Hydrophilic Cream versus in a Gel for the Treatment of Genital Herpes in Males: A Placebo‐Controlled, Double‐Blind, Comparative Study
Authors: Syed Tanweer A. , Ahmadpour Oliver Abbas , Ahmad Seyed Ali , Ahmad Seyed Hamzeh 
Published: April 2015

AbstractThe aim of this double‐blind, placebo‐controlled, comparative study was to differentiate the clinical efficacy and tolerability of human leukocyte interferon‐α incorporated (2 times 106 IU/g) in a hydrophilic cream and in a gel to heal males afflicted with first episodes of genital herpes. Patients (n=60), aged 18–40 years (mean 23.2) with culture‐confirmed diagnosis of herpes genitalis were randomized to three parallel groups. Each patient was allocated a precoded 40‐g tube, containing either preparation or placebo. Cream or gel was applied three times daily for 5 consecutive days. The duration of the active treatment was two weeks. Patients were examined after 48 hours of initial treatment, and thereafter two times a week. A reepithelialized lesion with some residual erythema was recorded as healed. The study demonstrated that patients treated with leukocyte interferon‐α cream had both significantly shorter mean duration of lesions than gel and placebo recipients (5.3 days vs. 8 days, 13 days respectively; p<0.001) and a higher number of healed patients (80% vs. 55%, 20% respectively; p<0.001). Of the 60 patients, 49 (82%) complained of no drug‐related side effects. Eleven patients predominantly in the cream/gel groups reported non‐objective transitory increase in their body temperature (>38°C) with moderate headache, malaise and myalgia. The study was followed‐up for 24 months after the first day of the treatment, and out of 31/60 cured patients, 4 had a relapse after 18 months.In conlusion the study affirmed that human leukocyte interferon‐α (2 times 106 IU/g) in a hydrophilic cream is more efficacious than its incorporation in gel or placebo, thus suggesting that leukocyte interferon‐α in a hydrophilic cream, with a profile of non‐objective mild to moderate drug‐induced indications, may be considered an alternative and effective treatment modality to cure male patients afflicated with first episodes of genital herpes.
Lupus Panniculitis Treated by a Combination Therapy of Hydroxychloroquine and Quinacrine
Authors: Chung Hae‐Shin , Hann Seung‐Kyung 
Published: April 2015

AbstractLupus erythematosus panniculitis (LEP) is an unusual clinical variant of lupus erythematosus (LE) in which the cutaneous inflammatory reaction occurs primarily in the deeper corium. The common clinical features of LEP includes asymptomatic, firm, sharply defined nodules. The histologic findings are characterized by nonspecific panniculitis composed of lymphoid cells, plasma cells, and histiocytes with varying degrees of necrobiotic changes with fibrinoid deposits.In our case, a 24‐year‐old male patient visited our clinic with non‐tender, hard, plaquelike lesions and overlying erythema on the left zygomatic, nasal, and submandibular area. Histopathologic and direct immunofluorescent findings of the lesion were compatible with LEP. His skin lesions waxed and waned with systemic steroid or hydroxychloroquine therapy. He has responded well to a combination therapy of hydroxychloroquine and quinacrine.
Neonatal Lupus Erythematosus Occurring in Identical Twins
Authors: Shimosegawa Masako , Akasaka Toshihide , Matsuta Mayumi 
Published: April 2015

AbstractThe patients were one‐month‐old identical twins. Scaly erythema was noted mainly on the trunk, face, and scalp of one twin starting about three weeks after birth and starting about two weeks after birth in the other. The patients' courses were observed without treatment; the eruptions tended to disappear two months after birth. The mother had a past history of transient facial erythema. Both twins and mother were positive for anti‐nuclear antibody, anti‐SS‐A antibody, and anti‐SS‐B antibody. The histopathological findings corresponded to those of discoid lupus erythematosus (DLE). The class of HLA typing revealed Cw3 in both twins, which is frequently observed in neonatal lupus erythematosus (NLE), and A24 in the mother, which is frequently observed in mothers of babies with NLE.
Zeis Gland Carcinoma
Authors: Kato Naoko , Sotodate Akihiro , Tomita Yuki 
Published: April 2015

AbstractSebaceous carcinoma of the Zeis gland of the cilia is a rare malignant tumor. A 90‐year‐old Japanese man with a Zeis gland carcinoma on the left upper eyelid is reported. The tumor was a 12 times 3‐mm, reddish, partially yellow, papillomatous nodule accompanied by loss of several lashes. Histologically, two types of tumor cells, a dark basaloid cell and a larger pale cell, showed lobular and comedo‐acinar growth patterns. The carcinoma did not recur during the 8 months following surgery; however, the patient died of gastric carcinoma.
Erythema Nodosum Leprosum in Histoid Leprosy: A Case Report
Authors: Kumar Vijay , Mendiratta Vibhu , Sharma Ravi C. , Kakar Nirupama , Bajaj Promila 
Published: April 2015

AbstractA 28‐year‐old married female developed histoid papules and nodules de novo over her face, extremities, back, buttocks and thighs. She had developed erythema nodosum leprosum lesions without any antileprosy treatment. Histopathology from a histoid nodule showed well defined nodular collections of plump, spindle‐shaped histiocytes. A few globi were also seen with Ziehl Neelson staining. Leucocytoclastic vasculitis was present in the ENL lesion. The CD4: CD8 ratio was 1.5:1.
Prolidase Activity in Chronic Wound and Blister Fluids
Authors: Oono Takashi , Fujiwara Yutaka , Yoshioka Toshiko , Arata Jirô 
Published: April 2015

AbstractWe investigated prolidase activity in samples derived from wound fluid as well as blister fluid. Prolidase activity was elevated in fluid samples collected from wounds over the levels in sera collected from patients with chronic wounds (P<0.05). Prolidase activity was also present in samples taken from blister diseases. However, prolidase activity in blister fluid was not higher than that in sera collected from patients with blister diseases. Our results indicate that prolidase may play a role in wound healing.
Toxic Epidermal Necrolysis Possibly Linked to Hyperacute Graft‐versus‐Host Disease after Allogeneic Bone Marrow Transplantation
Authors: Takeda Hikaru , Mitsuhashi Yoshihiko , Kondo Shigeo , Kato Yu‐ichi , Tajima Katsufumi 
Published: April 2015

AbstractToxic epidermal necrolysis (TEN) is a severe blistering skin disease of high mortality. TEN may occur after bone marrow transplantation (BMT). In such cases, TEN have been attributed to graft‐versus‐host disease (GVHD) or an adverse drug reaction. It is very difficult to distinguish the causes of TEN after BMT. We report a 21‐year‐old Japanese man who developed TEN eight days after BMT, evaluate the differential diagnosis of hyperacute GVHD and an adverse drug reaction, and deduce that hyperacute GVHD was the more likely pathogenesis of TEN in this patient.
An Autopsy Case of Angioimmunoblastic T‐cell Lymphoma with a High Content of Epithelioid Cells in the Lymph Node: Immunohistochemical and Genomic Analyses
Authors: Morita Kazumasa , Matsumura Yumi , Kudo Hitoshi , Fujii Kimio , Tachibana Takao , Ohta Keiji , Kamoto Toshiyuki , Okamoto Hiroyuki , Yamabe Hirohiko , Imamura Sadao , Fukumoto Manabu 
Published: April 2015

AbstractA 79‐year‐old female developed red papulonodular eruptions on her extremities, facial erythema, generalized lymphadenopathy and high fever. Histopathology of an affected lymph node showed the features of angioimmunoblastic T‐cell lymphoma with a high content of epithelioid cells. She died about two years after the onset despite therapy. Genomic Southern blotting and immunostaining of the lymph nodes were performed twice. In August of 1993, Southern blotting did not show any rearrangement of the immunoglobulin or the T‐cell receptor (TCR) gene. Small or medium‐sized lymphoid cells were positive for CD4 or CD8 (CD4:CD8=2:1). However, in September of 1994 (at autopsy), rearrangements of TCR Cβ1, Jβ2 and Jγ genes were observed. Small or medium‐sized lymphoid cells were positive for CD4, but negative for CD8. Several large cells were positive for Latent Membrane Protein 1 (LMP1) of the Epstein‐Barr virus (EBV). Our results proved that selective oligoclonal proliferation of tumor cells (probably CD4+) accompanied the disease progress.
A Case of Contact Dermatitis Due to Sodium Bisulfite in an Ophthalmic Solution
Authors: Nagayama Hirotoshi , Hatamochi Atsushi , Shinkai Hiroshi 
Published: April 2015

AbstractWe report a case of contact dermatitis due to sodium bisulfite in Tathion® eye drops. A 72‐year‐old woman was treated daily with two solutions including Tathion® eye drops for senile cataract for two years and three months. She developed edema, swelling, erythema, and vesicles on her eyelids. Because contact dermatitis due to a topical medication was suspected, patch testing was performed after disappearance of her eruption. A positive reaction to sodium bisulfite in Tathion® eye drops was confirmed. Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite. The reaction to sodium sulfite in the next patch testing was negative. To the best of our knowledge, this is the first report from Japan about contact dermatitis caused by this medication.
Acute Gout of the Right Sacroiliac Joint
Authors: Abraham Zeev , Glück Zahava 
Published: April 2015

AbstractAn eighty‐year‐old woman suffered from acute idiopathic gout of the right sacroiliac joint and tophaceous deposits in two fingers of her right hand. Hyperuricemia and findings consistent with gout detected by histological examination of a biopsy specimen taken from the digital nodules supported the diagnosis. The radiological workup revealed osteolytic changes at the bases of the phalanges in Roentgenograms of the feet. Various aspects of the very rare incidence of sacroiliac gout are discussed.
Arteriovenous Malformation in the Buttock: Treatment with a Combination of Selective Embolization and Excision
Authors: Ishihara Tsuyoshi , Hirooka Minoru , Ono Tomomichi 
Published: April 2015

AbstractArteriovenous malformation (AVM) in a 22‐year‐old Japanese female is reported. The malformation presented as a nontender, pulsating tumor. An area of marked hypervascularity was revealed in the dermis and muscles of the right buttock by arteriography. The tumor was removed after embolizing the right superior and inferior gluteal arteries, which were the main feeding arteries. Histological examination revealed a number of artery‐like vessels, encircled by proliferating capillaries. Follow‐up three years after excision showed no clinically remarkable changes. Selective embolization was useful for the excision.
Epidermal Differentiation and Squamous Metaplasia: From Stem Cell to Cell Death
Authors: Jetten Anton M. , Harvat Beth L. 
Published: April 2015

AbstractEpidermal differentiation is a multi‐step process defined by a cascade of interrelated changes in the expression of growth‐regulatory and differentiation‐specific genes (Fig. 1). Irreversible growth arrest is an early event in epidermal differentiation which occurs when cells transit from the basal to the innermost suprabasal layer of the skin and begin to express squamous‐specific genes. In culture, interferon γ, phorbol esters, confluence and growth in suspension are effective signals to induce irreversible growth arrest and differentiation. The induction of differentiation‐specific genes occurs either concomitantly with or following growth arrest and is believed to be linked to the molecular events that control irreversible growth arrest. Such a link has been demonstrated in other cell systems undergoing terminal differentiation, such as myogenesis and adipogenesis. Genes encoding proteins involved in the formation of the cross‐linked envelope are one set of squamous‐specific genes which are induced in the suprabasal layers and include transglutaminase I and III, involucrin, loricrin and cornifins/small proline‐rich proteins. Squamous‐specific genes exhibit not only different patterns of tissue‐specific expression but are also induced at different stages during differentiation, suggesting that transcription of individual genes is regulated by distinct mechanisms. The latter is supported by the identification of different sets of regulatory elements controlling the transcription of these genes. The importance of understanding both the mechanisms that regulate growth arrest and the differentiation program is emphasized by the association found between specific skin diseases and genetic alterations in growth‐regulatory genes as well as differentiation markers. In addition, studies into those mechanisms will provide insight into the control of squamous metaplasia and the development of squamous cell carcinomas.
Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis Are Severity Variants of the Same Disease which Differs from Erythema Multiforme
Authors: Roujeau Jean‐Claude 
Published: April 2015

AbstractA new classification, based on the pattern and distribution of cutaneous lesions, separates erythema multiforme major from Stevens‐Johnson syndrome. A retrospective reclassification of 76 cases supported the validity of that separation by demonstrating differing causes and pathology. Another prospective international case‐control study found differing demographic characteristics and risk factors between erythema multiforme major on the one hand and Stevens‐Johnson syndrome or toxic epidermal necrolysis on the other. Erythema multiforme major was mainly related to Herpes virus infection, while Stevens‐Johnson syndrome and toxic epidermal necrolysis were associated with drug reactions.
Hyperkeratosis of the Nipple: Report of Two Cases
Authors: Alpsoy Erkan , Yilmaz Ertan , Aykol Ayten 
Published: April 2015

AbstractHyperkeratosis of the nipple and areola is a rare condition; its characteristic properties are verrucous thickening and brownish discoloration of the nipples and areola. The nevoid form of the disease is extremely rare, usually seen in women in the second or third decade of life. The nipple is seldom affected alone.We report two cases of the nevoid form of hyperkeratosis of the nipple. In both female patients, lesions developed after puberty and were confined to both nipples alone. One of the patients' lesions became darker and more verrucous during pregnancy, making breast feeding impossible.
Rupioid Psoriasis Associated with Arthropathy
Authors: Wang Jung‐Luh , Yang Jen‐Hung 
Published: April 2015

AbstractWe reported a rare case of rupioid psoriasis associated with arthropathy. A 28‐year‐old male had suffered from severe arthritis for 6 months and had limpet‐like, cone‐shaped skin lesions on the extremities for 3 months. The histopathology revealed remarkable Munro's and Kogoj microabscesses, intense dermal edema, and moderate inflammatory cell infiltration. The radiological examination showed bilateral sacroilitis. The skin lesions and arthritis responded dramatically in three weeks to i.m. methotrexate combined with topical steroids and emollients and occlusive dressing technique. There was no recurrence of such skin lesions during the two year follow‐up period.
Pilomatricoma with a Bullous Appearance
Authors: Inui Shigeki , Kanda Ryoji , Hata Seiichiro 
Published: April 2015

AbstractA 15‐year‐old Japanese girl had an asymptomatic nodule on the right thigh of seven months' duration. The clinical appearance was similar to that of a bulla. There was a history of blunt trauma from dog scratch to the skin over the tumor shortly before tumor growth. Histopathological findings were consistent with pilomatricoma. In the overlying dermis, the collagen bundles were compressed to the tissue surrounding the tumor and the large space was seen. Around the tumor, some dilated endothelium‐lined vascular channels were found, which were identified as lymphatic vessels.
A Case Report of Twenty‐Nail Dystrophy
Authors: Ohta Yukinori , Katsuoka Kensei 
Published: April 2015

AbstractA case report of twenty‐nail dystrophy in a 21‐year‐old woman is presented. All her finger nails were affected with numerous small superficial pits. The histological findings showed the focal spongiotic change in the nail matrix reflecting the clinical appearance of the nail plate surface.
Immunohistochemical Localization of Nitric Oxide Synthase in Normal Human Skin: Expression of Endothelial‐type and Inducible‐type Nitric Oxide Synthase in Keratinocytes
Authors: Shimizu Yoshinori , Sakai Masao , Umemura Yoshiki , Ueda Hiroshi 
Published: April 2015

AbstractNitric oxide (NO) is a critical mediator of various biological functions. NO is generated from L‐arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial‐type NOS (eNOS) and brain‐type NOS (bNOS) are constitutive enzymes, and inducible‐type NOS (iNOS) is expressed after stimulation. We investigated the expression of NOS in normal human skin by an immunohistochemical technique and western blotting analysis. In human skin, epidermal keratinocytes and the outer root sheath were labeled with not only eNOS antibody but also with iNOS antibody. Both eNOS and iNOS protein in epidermal keratinocytes were confirmed by western blotting. eNOS immunoreactivity was observed in endothelial cells, fibroblasts, the arrector pili muscle, apocrine secretory gland, eccrine coiled duct, and eccrine secretory gland. bNOS immunoreactivity was observed in mast cells. No staining with anti‐bNOS antibody was observed in any other cell type. Our present findings suggest that epidermal keratinocytes in normal human skin contain both eNOS and iNOS.
Acquired Dermal Melanocytosis on the Wrist
Authors: Kuniyuki Shuichi 
Published: April 2015

AbstractA 50‐year‐old Japanese man had a blue‐black patch on the dorsum of his right wrist. Light and electron microscopic study of the lesion revealed dermal melanocytes containing mature melanosomes, predominantly in the upper dermis. This case was diagnosed as acquired dermal melanocytosis confined to the right wrist.
Cutaneous Mixed Tumor Containing Ossification, Hair Matrix, and Sebaceous Ductal Differentiation
Authors: Akasaka Toshihide , Onodera Hanae , Matsuta Mayumi 
Published: April 2015

AbstractA 58‐year‐old Japanese male presented with a cutaneous mixed tumor containing ossification and hair matrix differentiation on the left side of the chin.Histologically, the tumor consisted almost exclusively of apocrine‐type epithelial ductal structures and chondroid stroma. Strands and aggregation of basaloid cells which contained keratinous cystic structures with a column of shadow cells arising from basophilic basaloid cells, sebaceous duct‐like structures, and ossification in the stroma were also evident. These findings suggest that cutaneous mixed tumors with ossification and hair matrix differentiation are related to both the whole hair follicle and the sweat aparatus.
A Case of Recessive X‐Linked Ichthyosis: Scale‐Specific Abnormalities of Lipid Composition May Explain the Pathogenesis of the Skin Manifestation
Authors: Hamanaka Sumiko , Ujihara Mayumi , Serizawa Shigeo , Nakazawa Schuichi , Otsuka Fujio 
Published: April 2015

AbstractWe analyzed the lipid content of the scales, red blood cells, and plasma from a recessive X‐linked icthyosis patient. The patient's scales accumulated cholesterol sulfate, had decreased levels of free sterols, sterol esters and sphingolipids, and lacked phospholipids. Although the accumulation of cholesterol sulfate was found in the patient's red blood cells and plasma as well as in the scales, other lipid composition abnormalities were specific for scales. Such scale‐specific abnormal lipid composition may explain the pathogenesis of generalized hyperkeratosis and abnormal scaling of the disease.