bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Solar Radiation in North America: A Comparison of Observations, Reanalyses, Satellite, and Derived Products*
Authors: Slater Andrew G. 
Published: October 2015

Abstract
Observations of daily surface solar or shortwave radiation data from over 4000 stations have been gathered, covering much of the continental United States as well as portions of Alberta and British Columbia, Canada. The quantity of data increases almost linearly from 1998, when only several hundred stations had data. A quality-control procedure utilizing threshold values along with computing the clear-sky radiation envelope for individual stations was implemented to both screen bad data and rescue informative data. Over two-thirds of the observations are seen as acceptable. There are 15 different surface solar radiation products assessed relative to observations, including reanalyses [Twentieth-Century Reanalysis (20CR), CFS Reanalysis and Reforecast (CFSRR), ERA-Interim, Japanese 55-year Reanalysis Project (JRA-55), MERRA, NARR, and NCEP–NCAR Reanalysis 1 (NCEP-1)], derived products [observations from the CRU and NCEP-1 (CRU–NCEP); Daily Surface Weather and Climatological Summaries (Daymet); Global Land Data Assimilation System, version 1 (GLDAS-1); Global Soil Wetness Project Phase 3 (GSWP3); Multiscale Synthesis and Terrestrial Model Intercomparison Project (MsTMIP); and phase 2 of the North American Land Data Assimilation System (NLDAS-2)], and two satellite products (CERES and GOES). All except the CERES product have daily or finer temporal resolution. The RMSE of spatial biases is greater than 18 W m−2 for 13 of the 15 products over the summer season (June–August). None of the daily resolution products fulfill all three desirable criteria of low (&lt;5%) annual or seasonal bias, high correlation with observed cloudiness, and correct distribution of clear-sky radiation. Some products display vestiges of underlying algorithm issues [e.g., from the Mountain Microclimate Simulation Model, version 4.3 (MTCLIM 4.3)] or bias-correction methods. A new bias-correction method is introduced that preserves clear-sky radiation values and better replicates cloudiness statistics. The current quantity of data over the continental United States suggests that a solar radiation product based on, or enhanced with, observations is feasible.
The Occupation of the Parque Indoamericano in Buenos Aires: Discourse Dynamics and Stakeholder Practices
Authors: Hölzl Corinna 
Published: October 2015

In 2010, some 13,000 people occupied the second-largest park in Buenos Aires, located in the most deprived area of the city. The city and state governments reacted with violent repression leading to three deaths. After government officials promised that a housing program would be provided, the problem was viewed as “solved.” However, four years later not a single home had been built. Interpretive frames and political practices in Buenos Aires were influenced by the conflict, and this ultimately strengthened the positions of the national and local governments. This, in turn, intensified structural discrimination against lower-income groups in Buenos Aires. Thus, far from bringing about sustainable housing solutions, the occupation reinforced policies of security and sanction. En 2010, cerca de 13,000 personas ocuparon el segundo parque más grande de Buenos Aires, ubicado en la zona más pobre de la ciudad. Los gobiernos de la ciudad y del estado reaccionaron con una violenta represión que causó tres muertes. Después de que los funcionarios gubernamentales prometieron establecer un programa de vivienda, el problema se dio por “solucionado.” Sin embargo, cuatro años más tarde no se había construido ni una sola casa. Los marcos interpretativos y las prácticas políticas en Buenos Aires se vieron influenciados por el conflicto, y esto terminó por reforzar las posiciones de los gobiernos nacionales y locales. Esto, a su vez, intensificó la discriminación estructural contra los grupos de más bajos ingresos en Buenos Aires. Por consiguiente, lejos de traer soluciones de vivienda sostenibles, la ocupación reforzó las políticas de seguridad y sanción.
The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients
Authors: Siritho Sasitorn , Sato Douglas K , Kaneko Kimihiko , Fujihara Kazuo , Prayoonwiwat Naraporn 
Published: October 2015

Background: Myelin oligodendrocyte glycoprotein (anti-MOG) antibody was reported in anti-aquaporin-4 (anti-AQP4) seronegative neuromyelitis optica spectrum disorders (NMOSD) patients. Objectives: To describe clinical phenotypes associated with anti-MOG. Methods: Seventy consecutive Thai patients with inflammatory idiopathic demyelinating central nervous system disorders (IIDCD) who were previously anti-AQP4 seronegative were tested for anti-MOG. Results: Anti-MOG was positive in six patients, representing 20.7% of the IIDCD anti-AQP4 seronegative patients with a non-multiple sclerosis phenotype, and most had relapses. All first presented with optic neuritis with good visual recovery after treatment. Conclusions: Anti-MOG positive patients may have manifestations that mimic NMOSD but differ in their course and prognosis from anti-AQP4 positive NMOSD.
Interpreters – experts in careful listening and efficient encoding? Findings of a prose recall test
Authors: Hiltunen Sinikka , Vik Gun-Viol 
Published: October 2015

Research Questions: The purpose of the present experiment was to study interpreters’ recall of spoken prose. Design: The prose recall of simultaneous and consecutive interpreters was compared to that of foreign language teachers and non-linguistic experts. The professional experience of participants (21–24 participants in each group) was 10 years as a aminimum. The auditory presentation of the prose passage to be recalled, divided into eleven speech sequences, resembled the working conditions of interpreters. Data: Transcripted prose recall recordings were analysed quantitatively through an idea unit measure and qualitatively through meaning-based expressions. Findings: The foreign language expert groups outperformed the non-linguistic experts in both quantitative and qualitative measures. Additionally, compared to foreign language teachers, interpreters indicated a better recall of time expressions and topic sentences, as well as of complicated emotional and causal expressions. The explanation for these findings could indicate expertise-dependent tendencies: possibly a continuous practising of careful listening and the demand for a quick comprehension of the source text under the extreme time pressure of interpreters’ work leads to better results in prose recall. However, the findings can only be generalized to a limited extent because the prose passage used contained only one or two expressions of each type studied in the qualitative analysis. Originality: The study differs from previous studies in that the memory of interpreters, and especially of consecutive interpreters, was studied for the first time with a prose recall measure. Significance: The prose recall test revealed that the abilities of careful listening and effective comprehension of coherence and causality seem to play a significant role in explaining memory functions of simultaneous and consecutive interpreters compared to those of foreign language teachers and non-linguistic experts.
Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN
Authors: Simonneau Gérald , Channick Richard N. , Delcroix Marion , Galiè Nazzareno , Ghofrani Hossein-Ardeschir , Jansa Pavel , Le Brun Franck-Olivier , Mehta Sanjay , Perchenet Loic , Pulido Tomás , Sastry B.K.S. , Sitbon Olivier , Souza Rogério , Torbicki Adam , Rubin Lewis J. 
Published: October 2015

In SERAPHIN, a long-term, randomised, controlled trial (NCT00660179) in pulmonary arterial hypertension (PAH), macitentan significantly reduced the risk of morbidity/mortality and PAH-related death/hospitalisation. We evaluated disease progression and the effect of macitentan in treatment-naïve incident and prevalent cohorts.Patients allocated to placebo, or macitentan 3 mg or 10 mg were classified by time from diagnosis to enrolment as incident (≤6 months; n=110) or prevalent (>6 months; n=157). The risk of morbidity/mortality and PAH-related death/hospitalisation was determined using Cox regression.The risk of morbidity/mortality (Kaplan–Meier estimates at month 12: 54.4%versus26.7%; p=0.006) and PAH-related death/hospitalisation (Kaplan–Meier estimates at month 12: 47.3%versus19.9%; p=0.006) were significantly higher for incidentversusprevalent patients receiving placebo, respectively. There was no significant difference in the risk of all-cause death between incident and prevalent cohorts (p=0.587). Macitentan 10 mg significantly reduced the risk of morbidity/mortality and PAH-related death/hospitalisationversusplacebo in incident and prevalent cohorts.Incident patients had a higher risk for PAH progression compared with prevalent patients but not a higher risk of death. Macitentan delayed disease progression in both incident and prevalent PAH patients.
CC-chemokine ligand 2 inhibition in idiopathic pulmonary fibrosis: a phase 2 trial of carlumab
Authors: Raghu Ganesh , Martinez Fernando J. , Brown Kevin K. , Costabel Ulrich , Cottin Vincent , Wells Athol U. , Lancaster Lisa , Gibson Kevin F. , Haddad Tarik , Agarwal Prasheen , Mack Michael , Dasgupta Bidisha , Nnane Ivo P. , Flavin Susan K. , Barnathan Elliot S. 
Published: October 2015

The objective of this study was to determine the safety and efficacy of carlumab in the treatment of idiopathic pulmonary fibrosis (IPF).A phase 2, randomised, double-blind placebo-controlled dose-ranging study was conducted in patients with IPF (n=126). Patients were randomised to carlumab (1 mg·kg−1, 5 mg·kg−1, or 15 mg·kg−1) or placebo every 4 weeks. The primary endpoint was the rate of percentage change in forced vital capacity (FVC). Secondary endpoints were time to disease progression, absolute change in FVC, relative change in diffusing capacity of the lung for carbon monoxide (DLCO), and St George's Respiratory Questionnaire (SGRQ) total score.Due to a pre-planned, unfavourable interim benefit–risk analysis, dosing was suspended. The rate of percentage change in FVC showed no treatment effect (placebo −0.582%, 1 mg·kg−1−0.533%, 5 mg·kg−1−0.799% and 15 mg·kg−1−0.470%; p=0.261). All active treatment groups showed a greater decline in FVC (1 mg·kg−1−290 mL, 5 mg·kg−1−370 mL and 15 mg·kg−1−320 mL) compared with placebo (−130 mL). No effect on disease progression,DLCO, infection rates or mortality was observed. SGRQ scores showed a nonsignificant trend toward worsening with active treatment. Unexpectedly, free CC-chemokine ligand 2 levels were elevated above baseline at both 24 and 52 weeks. A higher proportion of patients with one or more serious adverse events was observed in the 5 mg·kg−1group (53.1%) compared with 1 mg·kg−1(15.2%), 15 mg·kg−1(21.9%) and placebo (46.4%), although no unexpected serious adverse events were noted.Although dosing was stopped prematurely, it is unlikely that carlumab provides benefit to IPF patients.
Enhanced angiogenesis in ischemic skeletal muscle after transplantation of cell sheets from baculovirus-transduced adipose-derived stromal cells expressing VEGF165
Authors: Makarevich Pavel I. , Boldyreva Maria A. , Gluhanyuk Evgeny V. , Efimenko Anastasia Yu , Dergilev Konstantin V. , Shevchenko Evgeny K. , Sharonov Georgy V. , Gallinger Julia O. , Rodina Polina A. , Sarkisyan Stepan S. , Hu Yu-Chen , Parfyonova Yelena V. 
Published: October 2015

Abstract
Introduction
Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. Administration technique is crucial and among others minimal constructs - cell sheets (CS) have certain advantages. Delivery of CS allows transplantation of cells along with matrix proteins to facilitate engraftment. Cells’ therapeutic potential can be also increased by expression of proangiogenic factors by viral transduction. In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia.

Methods
Mouse ADSC (mADSC) isolated from C57 male mice were expanded for CS formation (106cells per CS). Constructs were transduced to express human VEGF165 by baculoviral (BV) system. CS were transplanted subcutaneously to mice with surgically induced limb ischemia and followed by laser Doppler perfusion measurements. At endpoint animals were sacrificed and skeletal muscle was evaluated for necrosis and vessel density; CS with underlying muscle was stained for apoptosis, proliferation, monocytes and blood vessels.

Results
Using BV system and sodium butyrate treatment we expressed human VEGF165 in mADSC (production of VEGF165 reached ≈ 25-27 ng/ml/105 cells) and optimized conditions to ensure cells’ viability after transduction. Implantation of mock-transduced CS resulted in significant improvement of limb perfusion, increased capillary density and necrosis reduction at 2 weeks post-surgery compared to untreated animals. Additional improvement of blood flow and angiogenesis was observed after transplantation of VEGF165-expressing CS indicating enhanced therapeutic potential of genetically modified constructs. Moreover, we found delivery of mADSC as CS to be superior to equivalent dose of suspended cells in terms of perfusion and angiogenesis. Histology analysis of extracted CS detected limited proliferation and approximately 10 % prevalence of apoptosis in transplanted mADSC. Significant vascularization of CS and infiltration by monocytes were found in both – BV-transduced and control CS indicating graft and host interaction after transplantation.

Conclusions
Delivery of ADSC by subcutaneous transplantation of CS is effective for stimulation of angiogenesis and tissue protection in limb ischemia with a potential for efficacy improvement by BV transduction to express VEGF165.
A large and diverse collection of bovine genome sequences from the Canadian Cattle Genome Project
Authors: Stothard Paul , Liao Xiaoping , Arantes Adriano S. , De Pauw Mary , Coros Colin , Plastow Graham S. , Sargolzaei Mehdi , Crowley John J. , Basarab John A. , Schenkel Flavio , Moore Stephen , Miller Stephen P. 
Published: October 2015

Abstract

Background
The Canadian Cattle Genome Project is a large-scale international project that aims to develop genomics-based tools to enhance the efficiency and sustainability of beef and dairy production. Obtaining DNA sequence information is an important part of achieving this goal as it facilitates efforts to associate specific DNA differences with phenotypic variation. These associations can be used to guide breeding decisions and provide valuable insight into the molecular basis of traits.

Findings
We describe a dataset of 379 whole-genome sequences, taken primarily from key historic Bos taurus animals, along with the analyses that were performed to assess data quality. The sequenced animals represent ten populations relevant to beef or dairy production. Animal information (name, breed, population), sequence data metrics (mapping rate, depth, concordance), and sequence repository identifiers (NCBI BioProject and BioSample IDs) are provided to enable others to access and exploit this sequence information.

Conclusions
The large number of whole-genome sequences generated as a result of this project will contribute to ongoing work aiming to catalogue the variation that exists in cattle as well as efforts to improve traits through genotype-guided selection. Studies of gene function, population structure, and sequence evolution are also likely to benefit from the availability of this resource.
Complete genome sequence of Propionibacterium freudenreichii DSM 20271T
Authors: Koskinen Patrik , Deptula Paulina , Smolander Olli-Pekka , Tamene Fitsum , Kammonen Juhana , Savijoki Kirsi , Paulin Lars , Piironen Vieno , Auvinen Petri , Varmanen Pekka 
Published: October 2015

AbstractPropionibacterium freudenreichii subsp. freudenreichii DSM 20271T is the type strain of species Propionibacterium freudenreichii that has a long history of safe use in the production dairy products and B12 vitamin. P. freudenreichii is the type species of the genus Propionibacterium which contains Gram-positive, non-motile and non-sporeforming bacteria with a high G + C content. We describe the genome of P. freudenreichii subsp. freudenreichii DSM 20271T consisting of a 2,649,166 bp chromosome containing 2320 protein-coding genes and 50 RNA-only encoding genes.
Do phages impact microbial dynamics, prokaryotic community structure and nutrient dynamics in Lake Bourget?
Authors: Meunier Antony , Jacquet Stéphan 
Published: October 2015

ABSTRACTPhages are the most abundant and diversified biological entities in aquatic ecosystems. Understanding their functional role requires laboratory experiments on a short time-scale. Using samples of surface waters of Lake Bourget, we studied whether viruses impact (i) the abundance patterns of the bacterial and phytoplankton communities, (ii) a part of the prokaryotic community composition (both for Eubacteria and Archaea), and (iii) the recycling of nutrients and/or organic matter. Three experiments were performed (one each in February, March and April) at the transition between winter and spring in 2013. The experiment reduced or increased the abundance of virus-like particles in samples containing only the picoplanktonic fraction. Viral and cellular abundances, bacterial and archaeal community structures as well as nutrient concentrations were analysed every 24 h for 3 days. Some of the results reveal that increasing the phage abundance increased the diversity of the eubacterial community. Consistent with the ‘killing the winner’ concept, viruses are thus likely to significantly change the composition of the bacterial community. This suggests a positive association between viral abundance and bacterial diversity. In contrast, the composition of the archaeal community did not seem to be affected by phage abundance, suggesting the absence of viral control on this community or the inability to observe it at this period of year, either based on the time scale of the investigation or because the archaeal virus titre was too low to induce a significant and visible effect. Lastly, we were unable to demonstrate viruses driving the cycling of nutrients or the response of plankton to nutrient concentration changes in a significant way, suggesting that the role of viruses may be subtle or difficult to assess through the use of such experimental procedures.
UK national survey of management of breast lobular carcinoma in situ
Authors: Chester R , Bokinni O , Ahmed I , Kasem A 
Published: October 2015

IntroductionThere is no national standard treatment for patients with breast lobular carcinoma in situ (LCIS). Association of Breast Surgery guidelines for the management of breast cancer suggest that lesions containing LCIS should be excised for definitive diagnosis and recommend close surveillance after excision biopsy. The aim of this study was to form a picture of the current management of LCIS by UK breast surgeons.MethodsA questionnaire about the management of LCIS was sent to 490 UK breast surgeons.ResultsOf 490 questionnaires sent out, 173 (35%) were returned. When LCIS is present in a core biopsy, 61% of breast surgeons perform surgical excision, 22% would not excise but would continue follow-up and the remainder perform neither or set no clear management plan. Over half (54%) follow patients up with five years of annual mammography. If classic LCIS were found at the margins of wide local excision, 92% would not re-excise. Conversely, if pleomorphic LCIS were found, 71% would achieve clear margins. Respondents were split evenly regarding management of classic LCIS with a family history as 54% would not alter management whereas 43% would treat the disease more aggressively.ConclusionsOur survey has shown that in cases where LCIS is found at core biopsy, most surgeons follow Association of Breast Surgery guidance, obtaining further histological samples to exclude pleomorphic LCIS, ductal carcinoma in situ or invasive cancer, whereas others opt for annual surveillance and some discharge the patient. This study highlighted the huge variability in LCIS management, and the need for randomised controlled trials and input into national audits such as the Sloane Project to establish evidence-based national standard guidelines.
Determination of a safe INR for joint injections in patients taking warfarin
Authors: Bashir MA , Ray R , Sarda P , Li S , Corbett S 
Published: October 2015

Introduction With an increase in life expectancy in ‘developed’ countries, the number of elderly patients receiving joint injections for arthritis is increasing. There are legitimate concerns about an increased risk of thromboembolism if anticoagulation is stopped or reversed for such an injection. Despite being a common dilemma, the literature on this issue is scarce. Methods We undertook 2,084 joint injections of the knee and shoulder in 1,714 patients between August 2008 and December 2013. Within this cohort, we noted 41 patients who were taking warfarin and followed them immediately after joint injection in the clinic or radiology department, looking carefully for complications. Then, we sought clinical follow-up, correspondence, and imaging evidence for 4 weeks, looking for complications from these joint injections. We recorded International Normalised Ratio (INR) values before injection. Results No complications were associated with the procedure after any joint injection. The radiologists who undertook ultrasound-guided injections to shoulders re-scanned the joints looking for haemarthroses: they found none. A similar outcome was noted clinically after injections in the outpatient setting. Conclusion With a mean INR of 2.77 (range, 1.7–5.5) and a maximum INR within this group of 5.5, joint injections to the shoulder and knee can be undertaken safely in primary or secondary care settings despite the patient taking warfarin.
Litigation costs of wrong-site surgery and other non-technical errors in orthopaedic operating theatres
Authors: Harrison WD , Narayan B , Newton AW , Banks JV , Cheung G 
Published: October 2015

Introduction This study reviews the litigation costs of avoidable errors in orthopaedic operating theatres (OOTs) in England and Wales from 1995 to 2010 using the National Health Service Litigation Authority Database. Materials and methods Litigation specifically against non-technical errors (NTEs) in OOTs and issues regarding obtaining adequate consent was identified and analysed for the year of incident, compensation fee, cost of legal defence, and likelihood of compensation. Results There were 550 claims relating to consent and NTEs in OOTs. Negligence was related to consent (n=126), wrong-site surgery (104), injuries in the OOT (54), foreign body left in situ (54), diathermy and skin-preparation burns (54), operator error (40), incorrect equipment (25), medication errors (15) and tourniquet injuries (10). Mean cost per claim was £40,322. Cumulative cost for all cases was £20 million. Wrong-site surgery was error that elicited the most successful litigation (89% of cases). Litigation relating to implantation of an incorrect prosthesis (eg right-sided prosthesis in a left knee) cost £2.9 million. Prevalence of litigation against NTEs has declined since 2007. Conclusions Improved patient-safety strategies such as the World Health Organization Surgical Checklist may be responsible for the recent reduction in prevalence of litigation for NTEs. However, addition of a specific feature in orthopaedic surgery, an ‘implant time-out’ could translate into a cost benefit for National Health Service hospital trusts and improve patient safety.