bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 2502: Proteomic identification of carboplatin resistance in ovarian cancer cells.
Authors: Wrzeszczynski Kazimierz O. , Fan Gaofeng , Fu Cexiong , Pappin Darryl J. , Lucito Robert , Tonks Nicholas K. 
Published: August 2014

Abstract
The analysis of quantitative protein expression is necessary for the determination of actual biochemical protein concentrations that can lead to a more accurate description of cellular function. A knowledgebase of cancer function based on cellular protein levels can more directly implicate potential gene candidates for the detection and treatment of disease. Therefore, we analyzed iTRAQ (isobaric tag for relative and absolute quantification) data from 11 serous ovarian cancer cell lines and 2 normal ovarian surface epithelial cell lines. We profiled cellular protein abundance in over 3000 proteins with 749 proteins common to all 13 cell lines. Of the 749, 52 proteins exhibited elevated expression and 46 proteins had diminished expression in the cancerous cells when compared to the normal cell lines. We identified the 300 most variable iTRAQ expressed proteins based on median absolute deviation within 8 carboplatin sensitive and resistant cell lines. Using iTRAQ protein expression profiles from these 300 we successfully segregated the cell lines based on carboplatin sensitivity and resistance measurements. We further examined correlations among iTRAQ protein expression, individual gene RNA expression and DNA methylation data. There was no substantial correlation between protein abundance and RNA expression or epigenetic data. Furthermore RNA expression and DNA methylation data alone did not show any significant discrimination for chemosensitivity or resistance. We therefore present the potential of proteomics based discovery for carboplatin response in ovarian cancer and also identify putative gene candidates that may be functionally responsible for chemotherapy response which otherwise would not have been predicted using other singular whole genome data sources.
Citation Format: Kazimierz O. Wrzeszczynski, Gaofeng Fan, Cexiong Fu, Darryl J. Pappin, Robert Lucito, Nicholas K. Tonks. Proteomic identification of carboplatin resistance in ovarian cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2502. doi:10.1158/1538-7445.AM2013-2502
Abstract 2511: Comprehensive metabolic profiling of hepatocellular carcinoma and pancreatic tumors by capillary electrophoresis-mass spectrometry.
Authors: Tada Motohisa , Hirayama Akiyoshi , Kanai Fumihiko , Yoshitomi Hideyuki , Ohtsuka Masayuki , Miyazaki Masaru , Soga Tomoyoshi , Yokosuka Osamu 
Published: August 2014

Abstract
(Background) Most cancer types have been widely known to generate energy primarily by glycolysis rather than oxidative phosphorylation even under normoxia (Warburg effect). However, inadequate blood supply resulting from defective angiogenesis is often observed in different kinds of cancer tissues, and their microenvironment is considered nutritionally unfavorable. How these cancer cells generate ATP is therefore still unclear. We previously reported enhanced glycolysis and significant accumulation of all amino acids except glutamine in both colon and stomach cancer tissues (Hirayama A, et al Cancer Res 2009). (Methods) Here, we investigated the metabolic microenvironment of hepatocelluar carcinoma (HCC)(n=28, HBV-positive (B) 7, HCV-positive (C) 6, NonBnonC (NBNC) 15), and pancreatic tumors (n=40, Invasive ductal adenocarcinoma (PDAC) 21, Intraductal papillary mucinous adenoma (IPMA) 5, Intraductal papillary mucinous carcinoma (IPMC) 14), using capillary electrophoresis-mass spectrometry (CE-MS). (Results) The amount of glucose were more than ten times higher in liver tissues, which indicates that liver tissue exist in nutritionally favorable microenvironment even in tumor tissue compared with pancreas tissue. Significant lactate accumulation was found in all cancer tissues (HCC, IPMC, and PDAC), which imply enhanced glycolysis. However, significant organ-specific differences were found in the levels of amino acids. Organ and etiology-specific difference were found in intermediates of TCA cycle. For example, citrate was increased in B-HCC, malate was decreased in NBNC-HCC, fumarate was decreased in B-HCC, NBNC-HCC, and PDAC, citrate was decreased in IPMC, iso-citrate was decreased in PDAC, compared to normal tissue, significantly. The concentration of most amino acids were not changed between normal and tumor tissues in HCC and pancreatic tumors, which suggests that these type of cancers do not depend on autophagy for their amino acid source. (Conclusions)Overall, these results provide metabolic phenotypes of different cancer tissues that reflect the tumor microenvironment.
Citation Format: Motohisa Tada, Akiyoshi Hirayama, Fumihiko Kanai, Hideyuki Yoshitomi, Masayuki Ohtsuka, Masaru Miyazaki, Tomoyoshi Soga, Osamu Yokosuka. Comprehensive metabolic profiling of hepatocellular carcinoma and pancreatic tumors by capillary electrophoresis-mass spectrometry. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2511. doi:10.1158/1538-7445.AM2013-2511
Abstract 2512: Extreme value distributions describe cancer age-specific incidence data.
Authors: Soto-Ortiz Luis , Brody James P. 
Published: August 2014

Abstract
The incidence of cancers varies with age, if normalized this is called the age-specific incidence. A mathematical model that describes this variation should provide a better understanding of how cancers develop. We suggest that the age-specific incidence should follow an extreme value distribution, based on three widely accepted assumptions: (1) a tumor develops from a single cell, (2) many potential tumor progenitor cells exist in a tissue, and (3) cancer is diagnosed when the first of these many potential tumor cells develops into a tumor. We tested this hypothesis by comparing the predicted distribution to the age-specific incidence data for colon and prostate carcinomas collected by the Surveillance, Epidemiology and End Results network of 17 cancer registries. We found that colon carcinoma age-specific incidence data is consistent with an extreme value distribution, while prostate carcinomas age-specific incidence data generally follows the distribution. This model indicates that both colon and prostate carcinomas only occur in a subset of the population (22% for prostate and 13.5% for colon.) Because of their very general nature, extreme value distributions might be applicable to understanding other chronic human diseases.
Citation Format: Luis Soto-Ortiz, James P. Brody. Extreme value distributions describe cancer age-specific incidence data. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2512. doi:10.1158/1538-7445.AM2013-2512
Abstract 2516: Are alcohol drinking and cigarette smoking related to risk of glioma? A large prospective U.S. cohort study.
Authors: Braganza Melissa Z. , Rajaraman Preetha , Park Yikyung , Inskip Peter D. , Freedman Neal D. , Berrington de González Amy , Kitahara Cari M. 
Published: August 2014

Abstract
Background: Glioma is a relatively uncommon and highly fatal malignancy with few known risk factors. Alcohol consumption and cigarette smoking are associated with an increased risk of several types of cancer, but whether these exposures are related to the risk of glioma remains unclear.
Methods: We prospectively examined the relationship between cigarette smoking, alcohol intake, and risk of glioma in the National Institutes of Health-AARP Diet and Health Study, a large prospective cohort of 477,095 U.S. men and women between the ages of 50-71 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) for glioma risk according to alcohol intake (total alcohol, beer, wine, and liquor) and smoking status, intensity, and, among former smokers, time since quitting were calculated using models adjusted for sex, education, marital status, and race/ethnicity.
Results: During a median 10.5 person-years of follow-up, 492 men and 212 women were diagnosed with glioma. Among men, current, heavier (&gt;20 cigarettes per day) smoking was associated with a reduced risk of glioma compared to never smoking (HR=0.40, 95% CI: 0.21-0.79). Men who quit smoking &lt;5 years before baseline had a non-significant reduced risk of glioma (HR=0.73, 95% CI: 0.46-1.14) relative to male never smokers. Smoking behaviors were not associated with glioma risk in women. Greater alcohol consumption was associated with a decreasing risk of glioma in men (&gt;2 drinks per day versus &lt;1 drink per week: HR=0.65, 95% CI: 0.47-0.90; P-trend=0.02) but not women. An inverse association with greater beer intake was apparent both in men (&gt;2 drinks per day versus &lt;1 drink per week: HR=0.56, 95% CI: 0.33-0.93; P-trend=0.03) and women (≥1 drink per week versus &lt;1 drink per week: HR=0.66, 95% CI: 0.33-1.34; P-trend=0.27). Results were similar by education level, after mutual adjustment for smoking and alcohol, and after restricting to glioblastoma, the most common and lethal histological subtype of glioma.
Conclusions: Among men, current, heavy cigarette smoking and greater alcohol, particularly beer, consumption were inversely associated with the risk of glioma. Pooled analyses of prospective studies are needed to investigate more precisely the potential influence of these exposures on glioma risk.
Citation Format: Melissa Z. Braganza, Preetha Rajaraman, Yikyung Park, Peter D. Inskip, Neal D. Freedman, Amy Berrington de González, Cari M. Kitahara. Are alcohol drinking and cigarette smoking related to risk of glioma? A large prospective U.S. cohort study. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2516. doi:10.1158/1538-7445.AM2013-2516
Abstract 2517: Deaths due to smoking in a population where women started to smoke as teenagers: Nationally representative prospective cohort study.
Authors: Gram Inger T. , Sandin Sven , Braaten Tonje , Lund Eiliv , Weiderpass Elisabete 
Published: August 2014

Abstract
Background: Recent studies suggest that the population attributable fraction (PAF) of mortality due to smoking is larger than previously reported. We wanted to examine the effect of smoking on all-cause and cause-specific mortality and calculate the corresponding PAF in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.
Methods: We followed 85,320 women, aged 31-70 years, who completed a questionnaire in 1991-1997, through linkages to national registries through December 2008. Questionnaire data included information on lifestyle factors, including lifetime history of smoking. Poisson regression models were fitted to estimate relative risk s (RR) with 95% confidence intervals (CIs) adjusting for age, birth cohort, education, alcohol consumption and body mass index, all at enrollment. During a mean follow-up time of 14 years 2,842 deaths occurred. Compared with that of never smokers, current smokers had a mortality rate that was double (RR=2.38; 95% CI 2.17-2.62) from deaths overall, triple (RR=3.32; 95% CI 2.27-4.85) from cerebrovascular diseases, almost four fold (RR=3.71; 95% CI 2.21-6.21) from myocardial infarction (MI), twelve times (RR=12.26; 95% CI 7.89-19.07) from lung cancer and seventeen times (RR=17.08; 95% CI 5.98-48.81) from chronic obstructive pulmonary diseases . The attributable fraction and the PAF of mortality due to smoking was 47% and 30%, respectively Conclusions: We find that one in two deaths among ever smokers, and one in three deaths among middle aged women in Norway can be attributed to smoking. Our results may be generalizable to populations where women start to smoke as teenagers.
Citation Format: Inger T. Gram, Sven Sandin, Tonje Braaten, Eiliv Lund, Elisabete Weiderpass. Deaths due to smoking in a population where women started to smoke as teenagers: Nationally representative prospective cohort study. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2517. doi:10.1158/1538-7445.AM2013-2517
Abstract 2522: Complementary and alternative medicine use among cancer survivors in the United States.
Authors: Laiyemo Maryam , Nunlee-Bland Gail , Lombardo Frederick , Adams R. George , Laiyemo Adeyinka 
Published: August 2014

Abstract
Background: Although there is little evidence of effectiveness of Complementary and Alternative Medicine (CAM), there has been an increase in the number of patients turning to these largely unproven medical therapies. In this study, we sought to determine if those with a personal history of cancer were more likely to have utilized CAM as compared to those without a history of cancer.
Methods: We analyzed the 2007 Health Information National Trends Survey (HINTS) and identified 976 respondents who were cancer survivors and 6,235 respondents without a personal history of cancer. We compared the demographic, lifestyle, and healthcare perceptions of these participants and used logistic regression models to evaluate the association of personal history of cancer, cancer treatment and the time since cancer treatment with CAM use. We used survey weights in all analysis and Taylor series linearization to perform variance estimations to account for the complex survey design.
Results: Overall, cancer survivors were as likely as those without history of cancer to use CAM in the previous 12 months (27.1% vs. 25.2%; OR = 1.09; 95%CI: 0.86-1.38). Cancer treatment and time since cancer treatment was not associated with CAM use (Table 1).
Conclusions: Cancer survivors were as likely as adults without a history of cancer to use complementary and alternative medicine irrespective of cancer treatment.
Table 1. The effect of cancer treatment and time since treatment on CAM use among cancer survivors By cancer treatment Cancer survivor characteristics Weighted% with CAM use CAM use versus no CAM use OR (95% CI) No history of cancer (n = 6,235) 25.2% Reference No cancer treatment (n = 117) 32.6% 1.69 (0.82–3.47) Had cancer treatment (n = 847) 26.3% 1.01 (0.78–1.29) By time since cancer treatment No history of cancer (n = 6,235) Reference Still undergoing cancer treatment (n = 94) 29.4% 1.15 (0.50–2.63) Completed cancer treatment less than 1 year ago (n = 143) 22.6% 0.96 (0.55–1.66) Completed cancer treatment 1 or more years ago (n = 537) 26.5% 1.00 (0.72–1.41)
Adjusted for respondent's age, sex, marital status, place of birth, race, income, education level, health insurance status, BMI, perception of health status, perception of health care quality received, and confidence in taking care of one's own health
Citation Format: Maryam Laiyemo, Gail Nunlee-Bland, Frederick Lombardo, R. George Adams, Adeyinka Laiyemo. Complementary and alternative medicine use among cancer survivors in the United States. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2522. doi:10.1158/1538-7445.AM2013-2522
Abstract 2533: Inverse association between circulating vitamin D and mortality - dependent on sex and cause of death.
Authors: Rohrmann Sabine , Braun Julia , Bopp Matthias , Faeh David 
Published: August 2014

Abstract
Background: Vitamin D has immune-modulation properties as well as effects on cell differentiation and proliferation, on angiogenesis, but also on blood pressure and glucose tolerance, and in various populations, vitamin D deficiency is associated with chronic diseases and mortality. We examined the association between concentration of circulating 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, with all-cause and cause-specific mortality.
Methods: The study included 3191 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Serum 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and overall and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status.
Results: Mean serum 25(OH)D concentration was 19.8 ng/mL in men and 20.5 ng/mL in women. Participants with low 25(OH)D (≤13.4 ng/mL) were more likely to have participated during winter months, but less likely to have spent ≥30 minutes outdoors per day or been on vacation in the month prior to blood collection. Individuals with 25(OH)D concentrations ≥25 ng/mL tended to be less often of foreign nationality, current smokers and more frequently in the upper educational level. During the follow-up period, 459 study participants died (188 of cancer and 122 of cardiovascular diseases). Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR=0.83; 95% CI 0.74-0.92). Excluding the first five years of follow-up did not materially affect the observed associations. 25(OH)D concentration was inversely associated with cardiovascular mortality in women (0.68, 0.46-1.00), but not in men (0.97; 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (0.72, 0.57-0.91), but not in women (1.14, 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association.
Conclusion: 25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular- and cancer-related mortality.
Citation Format: Sabine Rohrmann, Julia Braun, Matthias Bopp, David Faeh. Inverse association between circulating vitamin D and mortality - dependent on sex and cause of death. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2533. doi:10.1158/1538-7445.AM2013-2533
Abstract 2540: Survival after cutaneous melanoma in kidney transplant recipients: a population-based matched cohort study.
Authors: Vajdic Claire M. , Chong Alvin H. , Kelly Patrick J. , Meagher Nicola S. , van Leeuwen Marina T. , Grulich Andrew E. , Webster Angela C. 
Published: August 2014

Abstract
BACKGROUND
Early detection and tailored treatment algorithms have resulted in improved outcomes for patients with cutaneous melanoma. Solid organ transplant recipients are at elevated risk of melanoma, and may have poorer outcomes than non-transplant recipients, although the evidence is unreliable.
METHODS
We conducted a national, population-based, matched cohort study of de novo invasive cutaneous melanoma in Australian kidney transplant recipients and in randomly selected members of the general population matched for age, sex, state of residence, and year of diagnosis (1982-2003). Melanoma histopathological characteristics were extracted from cancer registry notifications and date of death was obtained by linkage with the National Death Index (1982-2011). Kaplan Meier curves and Cox proportional hazard models were used to analyse the overall survival of transplant and non-transplant recipients, adjusted for matching and histopathological characteristics.
RESULTS
Compared to non-transplant recipients (n=202), melanomas in transplant recipients (n=75) were more likely to have a higher AJCC pathologic stage (P=0.003) at diagnosis. Survival was significantly lower for recipients compared to non-recipients, overall and for stage I melanomas (P&lt;0.001). Transplantation was associated with a significantly increased risk of death (adjusted hazards ratio 8.06; 95% confidence interval, 3.92 to 16.6, P&lt;0.0001). Pathologic stage (P=0.0004) and histology (P=0.009) also independently predicted risk of death.
CONCLUSIONS
Transplant recipients have a markedly poorer outcome than non-recipients after melanoma diagnosis. A review of patient education and skin cancer screening guidelines is warranted. Treatment algorithms developed for the general population with melanoma do not appear to apply to transplant recipients.
Citation Format: Claire M. Vajdic, Alvin H. Chong, Patrick J. Kelly, Nicola S. Meagher, Marina T. van Leeuwen, Andrew E. Grulich, Angela C. Webster. Survival after cutaneous melanoma in kidney transplant recipients: a population-based matched cohort study. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2540. doi:10.1158/1538-7445.AM2013-2540
Abstract 2543: A genome-wide analysis of ROHs identifies two susceptibility regions for non-cardia gastric cancer in han Chinese.
Authors: Hu Zhibin , Wang Cheng , Jin Guangfu , Lin Dongxin , Shen Hongbing 
Published: August 2014

Abstract
Runs of homozygosity (ROHs) are a novel class of genomic variation and may involve in the individual susceptibility to diseases. To better understand ROH and its relationship with non-cardia gastric cancer, we performed a genome-wide ROH analysis in two independent case-control studies (Nanjing study: 565 cases and 1,162 controls; and Beijing study: 468 cases and 1,123 controls) from Han Chinese populations. ROHs with a length from 0.5 to 1.5 Mb defined by at least 50 single nucleotide polymorphisms (SNPs) were evaluated with the association of non-cardia gastric cancer risk using genome-wide SNP data. We found that the overall ROH levels were significantly associated with a decreased risk of non-cardia gastric cancer risk (odds ratio (OR) =0.60; 95% confidence interval (CI): 0.50-0.73; P = 2.95×10-7). We also identified two ROHs at 15q13.2 and 2q14.2 that were consistently associated with non-cardia gastric cancer risk in both the Nanjing study (15q13.2: OR=0.55; and 2q14.2: OR=1.69) and the Beijing study (15q13.2: OR=0.41; and 2q14.2: OR=1.67). After combining the two studies, the association reached genome-wide significance level (9,749 ROHs, P&lt;5×10-6) for 15q13.2 (OR=0.51, 95%CI: 0.38-0.67, P=2.49×10-6) but not 2q14.2 (OR=1.68, 95%CI: 1.30-2.18, P=9.06×10-5). These results suggest that overall ROH levels may play a protective effect against non-cardia gastric cancer, and 15q13.2 and 2q14.2 regions may be new susceptibility loci for non-cardia gastric cancer.
Citation Format: Zhibin Hu, Cheng Wang, Guangfu Jin, Dongxin Lin, Hongbing Shen. A genome-wide analysis of ROHs identifies two susceptibility regions for non-cardia gastric cancer in han Chinese. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2543. doi:10.1158/1538-7445.AM2013-2543