bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primordial Vasculogenic Mimicry Formation in Uveal Melanoma
Authors: Bellido Daniel Delgado , Chacon-Barrado Antonio , Olmedo-Pelayo Joaquin , Perez Carmen Jordan , Garcia-Diaz Angel , pozo javier oliver , de Álava Enrique 
Published: July 2024

Abstract

Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults and where Vasculogenic Mimicry (VM) was first described. VM allows aggressive cancer cells to form blood networks independently, complicating treatment to patients from different tumor origin. Previous studies linked VE-Cadherin phosphorylation at Y658 to gene expression via Focal Adhesion Kinase (FAK) enhance the Kaiso/β-catenin/TCF-4 associates with VE-cadherin, enhancing VM. Disabling FAK prevents Y658 phosphorylation, causing VE-Cadherin/β-catenin dissociation and β-catenin degradation, reducing TCF-4-dependent gene transcription. Combined FAK inhibitor PF-271 and bevacizumab treatment significantly reduces tumor growth. Recently, an allosteric HIF2 inhibitor (Belzutifan) was FDA approved for VHL-associated ccRCCs and is in phase III testing for sporadic ccRCCs. In this original article, we decipher the primary causes of VM formation in UM patients with chromosome 3 loss and chromosome 8 gain, with VHL, BAP1, and FAK playing significant roles in initiating VM and consequently causing metastasis-related death in these patients. Using a combination of Belzutifan and FAKi, we observe a significant reduction in xenograft UM cells. In conclusion, we propose the combination of HIF-2i and FAKi as a prophylactic measure and for UM patients with metastasis, as this prevents VM formation and the hypoxic conditions generated by the chromosome 3 loss 8 gain.
Reducing Alcohol Misuse and Promoting Treatment Initiation Among Veterans Through a Brief Internet-Based Intervention: Protocol for a Randomized Controlled Trial
Authors: Pedersen Eric R , Davis Jordan P , Hummer Justin F , Bouskill Kathryn , Buch Keegan D , Shute Ireland M , Fitzke Reagan E , Tran Denise D , Neighbors Clayton , Saba Shaddy 
Published: July 2024

Background
Young adult veterans who served after the September 11 attacks on the United States in 2001 (ie, post-9/11) are at heightened risk for experiencing behavioral health distress and disorders including hazardous drinking, posttraumatic stress disorder, and depression. These veterans often face significant barriers to behavioral health treatment, and reaching them through brief mobile phone–based interventions may help reduce drinking and promote treatment engagement.

Objective
Following a successful pilot study, this randomized controlled trial (RCT) aims to further test the efficacy of a brief (ie, single session) mobile phone–delivered personalized normative feedback intervention enhanced with content to promote treatment engagement.

Methods
We will conduct an RCT with 800 post-9/11 young adult veterans (aged 18 to 40 years) with potentially hazardous drinking and who have not recently received treatment for any behavioral health problems. Participants will be randomly assigned to the personalized intervention or a control condition with resources for seeking care. The personalized normative feedback module in the intervention focuses on the correction of misperceived norms of peer alcohol use and uses empirically informed approaches to increase motivation to address alcohol use and co-occurring behavioral health problems. Past 30-day drinking, alcohol-related consequences, and treatment-seeking behaviors will be assessed at baseline and 3, 6, 9, and 12 months post intervention. Sex, barriers to care, posttraumatic stress disorder, depression, and severity of alcohol use disorder symptoms will be explored as potential moderators of outcomes.

Results
We expect recruitment to be completed within 6 months, with data collection taking 12 months for each enrolled participant. Analyses will begin within 3 months of the final data collection point (ie, 12 months follow-up).

Conclusions
This RCT will evaluate the efficacy of a novel intervention for non–treatment-seeking veterans who struggle with hazardous drinking and possible co-occurring behavioral health problems. This intervention has the potential to improve veteran health outcomes and overcome significant barriers to treatment.

Trial Registration
ClinicalTrials.gov NCT04244461; https://clinicaltrials.gov/study/NCT04244461

International Registered Report Identifier (IRRID)
DERR1-10.2196/59993
Persepsi Wisatawan Domestik Terhadap Daya Tarik Wisata Ditinjau Dari Komponen 4A
Authors: Saputra Guruh Anandra , Laba I Nengah , Muliadiasa I Ketut 
Published: July 2024

Penelitian ini bersifat deskriptif kuantitatif. Tujuan dari penelitian ini adalah untuk mengetahui persepsi wisatawan domestik di Pantai Pandawa lihat dari komponen 4A. Ulasan positif terhadap daerah tujuan wisata terkait Attraction, Amenities, Accessibility, Ancillary Service (4A) wisatawan menjadi salah satu kunci untuk menjamin perkembangan suatu daerah tujuan wisata. Dalam menganalisis hal tersebut digunakan teknik analisis statistik deskriptif. Metode pengumpulan data yang digunakan yaitu wawancara, kuesioner, dan observasi. Sampel pada penelitian ini terdiri dari 40 orang wisatawan domestik yang berkunjung ke Pantai Pandawa pada bulan September 2022. Total nilai persepsi rata-rata sebesar 29,86 berada pada interval 27,23 – 33,63 yang berarti persepsi wisatawan domestik terhadap daya tarik wisata Pantai Pandawa ditinjau dari komponen 4A masuk kategori baik. Komponen attraction mendapat nilai rata- rata sebesar 31,84; accessibilities mendapat nilai rata-rata sebesar 28,78; amenities memiliki nilai rata-rata sebesar 27,8; dan komponen ancillary service dengan nilai rata-rata sebesar 31,08. Komponen amenitas memperoleh penilaian rata-rata paling rendah.

This research is quantitative descriptive. The purpose of this study was to determine the perception of domestic tourist to the Pandawa Beach tourist attraction in terms of component 4A. Positive review of tourist destinations related to attraction, accessibilities, amenities, and ancillary services for tourist will be one of the keys to guaranteeing the development of tourist destinations. In analysing data, descriptive statistical data analysis techniques are used. Data collection methods used are interviews, questionnaires, and observation. The sample in this study consisted of 40 domestic tourist who visited Pandawa Beach in September 2022. The total average value of perception of 29,86 was in the interval of 27,23 – 33,63 which is means the perception of domestic tourists to the tourist attraction of Pandawa Beach in terms of component 4A is included in the good category. The attraction component got an average score of 31,84; accessibilities got an average score of 28,78; amenities scored an average of 27,8; and the ancillary services scored an average of 31,08. Thus the amenities component gets the lowest rating.
Strategi Tour and Travel dalam Meningkatkan Kualitas Pelayanan Pemandu Wisata
Authors: Riyadi I Putu Agus , Sutiarso Moh. Agus , Koeswiryono Dika Pranadwipa 
Published: July 2024

Jenis.penelitian menggunakan metode kualitatif dengan Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi Menggunakan. Teknik analisis SOAR (Strengths, Opportunities, Aspiration, dan Results). Alat analisis yang digunakan adalah pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Dengan adanya pelatihan-pelatihan yang diberikan oleh perusahaan maka akan meningkatkan kepercayaan diri pemandu wisata dan juga wawasan maupun pengetahuan mereka yang mana akan sangat berdampak baik kedepannya bagi citra perusahaan. Selain itu dengan adanya program pelatihan ini juga akan meningkatkan loyalitas pemandu wisata. Karena berdasarkan pengetahuan penulis selama ini, sangat jarang yang namanya perusahaan Travel Agent memberikan program seperti ini. Dengan adanya kerjasama antara agent luar perlu bagi pemandu wisata meningkatkan kualitas pelayan bagi wisatawan. Dengan adanya reward kemungkinan besar pemandu wisata akan lebih loyal terhadap perusahaan.Bisa dikatakan kinerja pemandu wisata sudah sangat bagus, tetapi terkadang ada beberapa hal kecil yang menyebabkan kesalahan seperti datang terlambat dan cara berpakaian yang kurang rapi.

This type of research is qualitative with data collection techniques using observation, interviews, and documentation. Using SOAR analysis technique (Strengths, Opportunities, Aspiration, and Results). The analytical tools used.are data. collection, data reduction, .data presentation, .and drawing conclusions. With the training provided by the company, it will increase the confidence of tour guides and also their insight and knowledge which will have a very good impact on the company's image in the future. In addition, this training program will also increase the loyalty of tour guides. Because based on the author's knowledge so far, it is very rare for Travel Agent companies to provide programs like this. With the cooperation between outside agents, it is necessary for tour guides to improve the quality of service for tourists. With a reward, it is likely that the tour guide will be more loyal to the company. It can be said that the performance of the tour guide has been very good, but sometimes there are some small things that cause errors such as arriving late and dressing that is not neat.
Analisis Pengelolaan Linen Housekeeping di Hotel
Authors: Wardana I Putu Wisnu , Parwati Komang Shanty Muni 
Published: July 2024

Penelitian ini membahas tentang Analisis Pengelolaan Linen Housekeeping (Room Linen) di Hotel Sheraton Bali Kuta Resort. Pengelolaan linen di Hotel Sheraton Bali Kuta Resort terbilang cukup baik namun akhir-akhir ini tidak jarang tamu mengeluhkan kondisi linen dan towel yang dianggap kurang baik atau dibawah standar. Tujuan penelitian ini yaitu mengatahui pengeloalaan dan hambatan dalam pengelolaan linen di Hotel Sheraton Bali Kuta Resort. Penelitian ini dilakukan di bulan Januari 2023 sampai Juni 2023 dan jenis penelitian yaitu deskritif kualitatif dan teknik analisis data menggunakan analisis data deskritif kuanitatif. Hasil dari penelitian yaitu kurangnya jumlah linen serta perlu adanya penambahan jumlah linen yang jumlahnya tidak memadai seperti pillow case, hand towel, face towel, batrobe. Selain itu beberapa pengelolaan room linen perlu ditingkatkan. Terdapat proses yang tidak dikelola sempurna, masih beredarnya linen yang rusak. Perlu adanya evaluasi dan pengawasan yang dilakukan agar memberikan kinerja yang lebih baik.

This study discusses the analysis of Linen Housekeeping Management (Room Linen) at Sheraton Bali Kuta Resort Hotel. Linen management at Sheraton Bali Kuta Resort Hotel is quite good but lately it is not uncommon for guests to complain about the condition of linen and towels which are considered poor or below standard. The purpose of this research is to know the management and obstacles in linen management at Sheraton Bali Kuta Resort Hotel. This research was conducted from January 2023 to June 2023 and the type of research is quantitative descriptive and data analysis techniques using qualitative descriptive data analysis. The results of the study are the lack of linen and the need to increase the number of inadequate linen such as pillow cases, hand towels, face towels, batrobe. In addition, some room linen management needs to be improved. There are processes that are not perfectly managed, and damaged linen is still circulating. There needs to be evaluation and supervision carried out in order to provide better performance.
Strategi Promosi dalam Penjualan Restoran pada Masa Pemulihan Pandemi Covid-19
Authors: Renda Putu Addie Dianatha , Muliadiasa I Ketut 
Published: July 2024

Strategi promosi adalah suatu tindakan untuk mencapai sasaran yang diinginkan dalam suatu bisnis, hal ini sangat diperlukan dalam hal penjualan jasa maupun barang, tentunya dalam melakukan strategi promosi sangat penting untuk memperhatikan pasar yang sedang beredar maupun situasi yang dialami disekitar lokasi restoran, untuk meningkatkan suatu penjualan. Jaya at The Setai merupakan restoran yang berada dibawah The Setai Hotel Miami yang salah satu dari banyak restoran di Miami yang mengalami penutupan selama 1 tahun akibat dari Pandemi COVID-19, dan saat awal buka kembali tentunya penjualan sangat rendah dari sebelumnya, maka untuk memulihkan dan meningkatkan penjualan strategi promosi baru sangat diperlukan dalam masa pemulihan sektor pariwisata di bidang restoran yang mulai bangkit perlahan dalam situasi pemulihan ini. Sehingga tujuan dari penelitian ini adalah untuk mengetahui beberapa strategi promosi yang digunakan untuk menarik minat pelanggan dimasa pemulihan pandemic covid-19.

The promotion strategy is an action to achieve the desired goals in a business, this is very necessary in terms of selling services and goods, of course in carrying out a promotion strategy it is very important to pay attention to the market that is currently circulating and the situation experienced around the location of the restaurant, to increase sales. . Jaya at The Setai is a restaurant under The Setai Hotel Miami which is one of the many restaurants in Miami which has been closed for 1 year as a result of the COVID-19 Pandemic, and when it first reopened of course sales were very low compared to before, so to recover and increasing sales a new promotion strategy is urgently needed during the recovery period of the tourism sector in the restaurant sector which is starting to revive slowly in this recovery situation. So the purpose of this research is to find out some of the promotional strategies used to attract customers during the recovery from the Covid-19 pandemic.
Efektivitas J1 Internship Bagi Mahasiswa Pariwisata Internasional
Authors: Devi Ayu Mega Paramitha , Susanti Luh Eka 
Published: July 2024

Banyaknya tuntutan dunia karir masa kini, semakin banyak program kuliah yang melibatkan program magang. J1 sendiri merupakan visa magang/training bagi mahasiswa/I yang berkeinginan melakukan training di United State of America selama setahun. Kata efektif di ambil dari kata efek yang artinya akibat atau pengaruh dari suatu unsur. Tujuan dari penelitian ini untuk mengetahui efektivitas J1 internship bagi mahasiswa IPB Internasional. Penelitian ini menggunakan Teknik pengumpulan data berupa kuesioner yang disebar melalui google form dan dokumentasi. Hasil dari penelitian , efektivitas J1 internship bagi mahasiswa IPB Internasional secara umum J1 internship dapat di katakan efektiv . para mahasiswa mampu menyelesaikan program dengan baik serta para mahasiswa mendapat pengalam yang akan berguna di masa depan, namu beberapa mahasiswa mengalami kesulitan dalam mengikuti J1 program ini.

With the many demands of today's career world, more and more college programs involve apprenticeship programs. J1 itself is an apprentice/training visa for students who wish to conduct training at the United States of America for a year. The word effective is taken from the word effect which means the effect or influence of an element. The purpose of this study was to determine the effectiveness of the j1 internship for The International Institute of Tourism & Business students. This study uses data collection techniques in the form of questionnaires distributed through google forms and documentation. The results of the research, the effectiveness of the J1 internship for The International Institute of Tourism & Business students students in general, the J1 internship can be said to be effective. The students were able to complete the program well and the students got experience that would be useful in the future, but some students experienced difficulties in participating in this J1 program.
Subtitusi Tepung Sorgum dalam Pembuatan Kue Kering Havermut
Authors: Gracia Gabriela , Wardana Miko Andi 
Published: July 2024

Untuk menciptakan inovasi terbaru bagi para penderita celiac, serta mengurangi tingginya angka impor tepung terigu, pada kesempatan ini penulis akan menggunakan tepung sorgum sebagai bahan tambahan dan bahan pengganti untuk tepung terigu dalam pembuatan kue kering havermut. Maksud dan tujuan dari penelitian ini adalah untuk mengetahui kualitas kue kering havermut dengan tepung sorgum dibandingkan dengan kue kering havermut dengan penggunaan tepung terigu serta diperuntukkan untuk kalangan gluten free. Metode penelitian yang digunakan adalah ADDIE (Analyze, Design, Develop, Implement, & Evaluate). Untuk Teknik Pengumpulan data, penelitian ini menggunakan teknik deskriptif kuantitatif berbasis uji organoleptik dan uji minat konsumen dengan penilaian 30 panelis, 8 panelis ahli di bidang tataboga, 4 pegawai swasta, dan 18 mahasiswa. Hasil penelitian untuk 100% tepung sorgum yang diuji kepada 30 panelis dan mendapatkan skor warna 123 (menarik) dan skor rasa 132 (sangat enak) dan skor aroma 115 (harum) dan skor tekstur 130 (sangat renyah). Berdasarkan hasil uji daya tahan, kue kering havermut dengan tepung sorgum dapat bertahan hingga satu bulan. Hasil dari uji minat beli konsumen, masyarakat tertarik untuk membeli produk ini. Biaya total (fixed cost) dan biaya variabel (variable cost) dalam pembuatan kue kering havermut dengan subtitusi tepung sorgum ini adalah Rp. 69.050 dan setelah dihitung menggunakan rumus akan dijual dengan harga Rp. 30.000 per toples 250 gr.

To create the lastest innovations for celiac sufferers and reduce the high number of wheat flour imports, on this occasion the author will use sorghum flour as an additive or a substitute for wheat flour in making oatmeal cookies. The aims and purposes of this study were to determine the quality of oatmeal cookies with sorghum flour compared to oatmeal cookies using wheat flour and for gluten free people. The research method is ADDIE (Analyze, Design, Develop, Implement, & Evaluate). For collect the data, this study used a quantitative descriptive technique based on organoleptic tests and customer interest tests with the assessment of 30 panelists, 8 expert panelists in the field of culinary arts, 4 private employees, and 18 students. The results for 100% sorghum flour were tested on 30 panelist and obtained a color score 123 (attractive) and a taste score of 132 (very tasty) and aroma score of 115 (fragrant) and a texture score of 130 (very crunchy). Based on the durability test results, oatmeal cookies with sorghum flour can last up to one month. The results of the customer buying interest test show that people are interested in buying this product. The total cost (fixed cost) and variable cost in making this oatmeal cookies with sorghum flour substitution is Rp.69.050 and after being calculated using the formula it will be sold at Rp.30.000 for one jar of 250 gr.
Pemanfaatan Daun Cemcem sebagai Bahan Tambahan Pada Panna Cotta
Authors: Dewi Ni Made Ayu Candra , Sudiarta I Nyoman 
Published: July 2024

Penelitian ini membahas tentang Pemanfaatan Daun Cemcem Sebagai Bahan Tambahan Pada Panna Cotta. Penggunaan daun cemcem pada panna cotta ini diharapkan dapat menjadi salah satu alternatif makanan sehat yang menggunakan bahan tambahan tanaman herbal untuk mendorong orang untuk mengonsumsi makanan sehat. Tujuan dari penelitian ini adalah untuk menentukan kualitas dan masa kadaluarsa panna cotta dengan bahan tambahan daun cemcem. Analisis deskriptif kuantitatif digunakan untuk menganalisis tes uji organoleptik yang dinilai oleh 30 responden, dan analisis deskriptif kualitatif digunakan untuk memahami data tentang masa kadaluarsa. Hasil uji organoleptik menunjukkan bahwa panna cotta dengan daun cemcem memiliki skor 111 poin untuk indikator rasa, skor 127 poin untuk indikator warna, skor 122 poin untuk indikator tekstur, dan skor 106 poin untuk indikator aroma. Hasil penelitian menunjukkan bahwa panna cotta dengan bahan tambahan daun cemcem memiliki rasa yang enak, warna yang sangat menarik, tekatur yang lembut, dan bau harum. Panna cotta dengan bahan tambahan daum cem-cem ini dapat bertahan lima hari pada refrigerator dan satu hari pada suhu ruangan. Dapat disimpulkan bahwa daun cemcem ini dapat dimanfaatkan untuk membuat panna cotta, yang memiliki rasa dan sensasi yang berbeda dari panna cotta biasa.

This study discusses the use of Cemcem leaves as an additional ingredient in Panna Cotta. The use of cemcem leaves in panna cotta is expected to be an alternative to healthy foods that use herbal plant additives to encourage people to eat healthy foods. The purpose of this study was to determine the quality and expiration period of panna cotta with cemcem leaf additives. Quantitative descriptive analysis was used to analyze organoleptic test tests assessed by 30 respondents, and qualitative descriptive analysis was used to understand data about expiration times. The organoleptic test results showed that panna cotta with cemcem leaves had a score of 111 points for the taste indicator, a score of 127 points for the color indicator, a score of 122 points for the texture indicator, and a score of 106 points for the aroma indicator. The results showed that panna cotta with cemcem leaf additives has a good taste, very attractive color, soft texture, and fragrant smell. Panna cotta with daum cem-cem additives can last five days at refrigerator and one day at room temperature. Itcan be concluded thatthis cemcem can be used to make panna cotta , which has a different taste and sensation from ordinary panna cotta.
Implementasi Hygiene Sanitasi terhadap Pengolahan Bahan Makanan
Authors: Tumbol Raldy Semuel Levinus , Purnantara I Made Hadi 
Published: July 2024

Di masa pandemi COVID-19, praktik kebersihan sangat diperlukan di hotel, terutama di sektor makanan dan minuman. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana praktek sanitasi yang diterapkan dalam pengolahan bahan makanan di pasar Stratton. ) dan apakah sudah benar, dalam prakteknya metode pengumpulan data dilakukan dengan cara observasi, wawancara dan dokumentasi. Teknik analisis yang digunakan dalam penelitian ini adalah deskriptif stabil. Survei praktik di restoran menunjukkan bahwa standar tidak terpenuhi dalam praktik kebersihan yang diterapkan. Untuk itu evaluasi dan pelatihan perlu dilakukan untuk meningkatkan implementasi SOP dari sebelumnya.

During the COVID-19 pandemic, cleanliness practices are very necessary in hotels, especially in the food and beverage sector. The aim of this research is to find out how sanitation practices are applied in processing food ingredients at the Stratton market. ) and is it correct, in practice the data collection method is carried out by means of observation, interviews and documentation. The analysis technique used in this research is stable descriptive. A survey of restaurant practices indicated that standards were not met in the hygiene practices implemented. For this reason, evaluation and training need to be carried out to improve the implementation of SOPs from before.