bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative Measurement-Based Approach to Supratip Deformity in Open Structural Rhinoplasty
Authors: Şibar Serhat , Erdal Ayhan Işık , Doruk Mert , Gündüz Nurullah , Özçiler Mehmet Fatih 
Published: July 2024

Background
Supratip deformity is one of the most common complications after open rhinoplasty. This study aimed to define a new risk scoring system for supratip deformity and determine the distances that should be left between the tip defining point (TDP) and anterior septal angle (ASA) to prevent it.

Methods
Four hundred sixty-nine patients who underwent open rhinoplasty between 2018–2022 were included in this retrospective study. The patients were evaluated according to the risk scoring system consisting of four parameters (skin thickness, lower lateral cartilage anatomy, amount of hump resection, and soft tissue procedures). Because of the presence of supratip deformity at the postoperative 12th month, the patients were divided into two groups: (i) without supratip deformity (n = 418) and (ii) with supratip deformity (n = 51). Statistical inferences were made regarding the development of supratip deformity by evaluating the relationship between the risk scores and the intraoperative TDP-ASA distances.

Results
There was a significant difference between the groups in risk scores (P < 0.05). In cases with high-risk scores, it was calculated that the probability of developing supratip deformity decreased significantly when the TDP-ASA distance was above 7.5 mm and increased significantly when the TDP-ASA distance was below 6.5 mm. In cases with low-risk scores, it was found that the probability of developing supratip deformity was reduced considerably when the TDP-ASA distance was over 6.0 mm.

Conclusions
The authors recommend keeping the TDP-ASA distance above 6.0 mm in low-risk patients and 7.5 mm in high-risk patients to avoid supratip deformity.
Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression
Authors: Tonkul Mustafa , Baune Bernhard T. , Kavakbasi Erhan 
Published: July 2024

Introduction
Intermittent theta burst stimulation (iTBS) is a novel form of repetitive transcranial magnetic stimulation (rTMS) conducted in patients with treatment-resistant depression (TRD). In this retrospective naturalistic study, we investigated the outcome of iTBS in treatment-resistant depression patients with (ECT+) and without (ECT−) history of electroconvulsive therapy (ECT) in their current depressive episode, as well as among previous ECT responders and nonresponders.

Methods
We included 66 inpatients (57.6% women; mean age, 52.7 years) at a German University Department of Psychiatry. A binary logistic regression model was utilized to investigate the impact of ECT treatment history on response to iTBS.

Results
Overall response rate was 51.5%. History of ECT in the current episode was present in 47% of patients. In the regression model, history of ECT in the current episode was associated with significantly worse response to iTBS (odds ratio, 0.252; 95% confidence interval, 0.085–0.743; P = 0.013), whereas other disease- and treatment-related covariates had no significant impact on treatment outcome. In the ECT+ group, ECT nonresponders showed a significantly worse outcome of iTBS than ECT responders. Overall rate of treatment discontinuations was 3%.

Conclusions
In this study, iTBS was most effective in patients without history of ECT in the current episode. Previous ECT responders had better outcome following iTBS than ECT nonresponders. Hence, patients with ECT response, who had to discontinue ECT due to side effects or complications, may be considered suitable candidates to be switched to iTBS.
comparison of genetic diversity and phylogenetic structure of 18S gene ofTrichomonas vaginalisin Hainan and Xinjiang provinces
Authors: Liu Jun , Dong Xiaoyang , Wang Daping , Chen Min , Nie Jing , Xiao Man 
Published: July 2024

AbstractTrichomonas vaginalisis a kind of flagellate parasite endemic all of the world. study compared the difference of genetic diversity and phylogenetic structure of 18S ribosomal RNA gene ofT. vaginalisfrom Hainan and Xinjiang Provinces, China. 20 samples and 47 samples from Hainan and Xinjiang respectively which confirmed for infection with T.vaginalis. The sequences were aligned using MEGA 11 software and phylogenetic trees were drawn by Neighbor-Joining method. The number of mutation, nucleotide diversity, and haploid diversity were analyzed using Dnaspv5 software. For Hainan samples, the analyses showed 31 polymorphisms, creat different haplotypes with a haplotype diversity of 0.589. Nucleotide diversity and average nucleotide different amongT.vaginaliswere estimated as 0.00679 and 3.447, respectively.Tajima’s D value in Tajiama’s neutrality test was -2.48147,which was significant (p<0.001). But for Xinjiang samples, the analyses showed 31 polymorphisms, creat different haplotypes with a haplotype diversity of 0.731. Nucleotide diversity and average nucleotide different among T.vaginalis were estimated as 0.00497 and 2.50435, respectively. Tajima’s D value in Tajiama’s neutrality test was -2.26284, which was significant (p<0.01). For all the sequence in this study, all the sequences form one phylogenetic tree, some of the sequence from two provinces showed a certain aggregating phenomenon. The differences between the samples from two province maybe for the local environment, ethnic, sample number and so on, it need further study for T.vaginalis.
The Association between Endometriosis and Immunological diseases
Authors: Shigesi Nina , Harris Holly R. , Fang Hai , Ndungu Anne , Lincoln Matthew R. , Cotsapas Chris , Knight Julian , Missmer Stacey A. , Morris Andrew P. , Becker Christian M. , Rahmioglu Nilufer , Zondervan Krina T. ,   The International Endometriosis Genome Consortium,   The 23andMe Research Team
Published: July 2024

AbstractThe evidence for a greater prevalence of immunological-diseases among endometriosis patients has varied in robustness and been subject to selection bias. We investigated the phenotypic and genetic association between endometriosis and 31 immunological-diseases in the UK Biobank (8,223 endometriosis, 64,620 immunological-disease cases). In cross-sectional and retrospective cohort analyses, endometriosis patients were at significantly increased (30-80%) risk of classical- autoimmune (rheumatoid arthritis, multiple sclerosis, coeliac disease), autoinflammatory (osteoarthritis) and mixed-pattern (psoriasis) diseases. Osteoarthritis (genetic-correlation (rg)=0.28, P=3.25×10-15), rheumatoid arthritis (rg=0.27, P=1.54×10-5) and multiple sclerosis (rg=0.09, P=4.00×10-3) were significantly genetically correlated with endometriosis. Mendelian randomisation analysis suggested a causal association between endometriosis and rheumatoid arthritis (OR=1.16, 95%CI=1.02-1.33). Expression QTL analyses highlighted effector genes enriched for seven pathways across all four conditions, with three genetic loci shared between endometriosis and osteoarthritis and one with rheumatoid arthritis. Although the increased risk of immunological-diseases among endometriosis patients is modest, their shared genetic basis opens-up opportunities for new treatments.
The Evolving Landscape of Substance Use Disorder Mortality in the United States: A Spatiotemporal Analysis of Emerging Hotspots and Vulnerable Populations (2005-2020)
Authors: Escobar Santiago , MacKinon Neil J. , Ambade Preshit , Hoffman Zach , Cuadros Diego F 
Published: July 2024

AbstractThe escalating Substance Use Disorder (SUD) crisis in the U.S., marked by a significant rise in mortality since 1999, underscores the urgent need for a comprehensive analysis of its spatiotemporal dynamics. This study aims to elucidate the heterogeneous geospatial distribution of SUD mortality, identifying specific locations where vulnerable communities face heightened risk. By examining SUD mortality data from the CDC for the period 2005-2020, we applied scan statistics to delineate temporal and geospatial clusters of elevated SUD-related deaths, further dissecting these patterns across racial subpopulations and regions. Our findings reveal 27 distinct clusters nation-wide, predominantly emerging post-2013 and persisting until 2020, indicating a shifting epicenter of the epidemic. Notably, the white subpopulation was associated with 26 clusters, closely mirroring the broader national trends, yet with a pronounced concentration in the eastern U.S. Conversely, the black subpopulation demonstrated a different pattern, with 17 clusters arising between 2013 and 2020, primarily post-2015, suggesting a temporal and spatial divergence in the impact of the epidemic across racial subpopulations. This analysis not only highlights the critical need for targeted public health interventions and policies but also calls for continued surveillance to monitor and mitigate the evolving SUD crisis. By understanding the complex spatiotemporal and racial variations in SUD mortality, we can better allocate resources, develop effective prevention strategies, and support the communities most in need.
Subsurface Microbial Colonization at Mineral-Filled Veins in 2-Billion-Year-Old Igneous Rock from the Bushveld Complex, South Africa
Authors: Suzuki Yohey , Webb Susan J. , Kouduka Mariko , Kobayashi Hanae , Castillo Julio H. , Kallmeyer Jens , Moganedi Kgabo , Allwright Amy J. , Klemd Reiner , Roelofse Frederick , Mapiloko Mabatho , Hill Stuart J. , Ashwal Lewis D. , Trumbull Robert B. 
Published: July 2024

AbstractRecent advances in subsurface microbiology have demonstrated the habitability of multi-million-year-old igneous rocks, despite the scarce energy supply from rockwater interactions. Given the minimal evolution coupled with exceedingly slow metabolic rates in subsurface ecosystems, spatiotemporally stable igneous rocks can sustain microbes over geological time scales. This study investigated 2-billion-year-old igneous rock in the Bushveld Complex, South Africa, where ultradeep drilling is being executed by the International Continental Scientific Drilling Program (ICDP). New procedures were successfully developed to simultaneously detect indigenous and contaminant microbial cells in a drill core sample. Precision rock sectioning coupled with infrared, fluorescence and electron microscopy imaging of the rock section with submicron resolution revealed microbial colonization in veins filled with smectite. The entry and exit of microbial cells in the veins are severely limited by tight packing with smectite, the formation of which supplies energy sources for long-term habitability. Further microbiological characterization of drilled rock cores from the Bushveld Complex will expand the understanding of microbial evolution in deep igneous rocks over 2 billion years.
Genetic architecture of the tomato fruit lipidome; new insights link lipid and volatile compounds
Authors: Kuhalskaya Anastasiya , Li Xiang , Lee Jeongah , Gonda Itay , von Steimker Julia , Bulut Mustafa , Karakas Esra , Fisher Josef , Krämer Konrad , Vanholme Ruben , Rosental Leah , Ahchige Micha Wijesingha , Garbowicz Karolina , Klemmer Annabella , Ruß Anne-Kathrin , Donath Andreas , Cuadros-Inostroza Alvaro , Boerjan Wout , Tieman Denise , Zamir Dani , Klee Harry , Alseekh Saleh 
Published: July 2024

AbstractTomato (Solanum lycopersicum L.) fruit flavor is determined by a combination of multiple volatile compounds, including several derived from lipids and fatty acids. Although fruit flavor has been intensively studied, the linkage between lipid metabolism and flavor remains largely undefined. Here, we performed a genome-wide association study (GWAS) and QTL mapping for the fruit lipid content from 550 tomato accessions and 107 backcross inbred lines (BILs) in two consecutive seasons. Over 130 lipid compounds were identified and mapped, allowing for the identification of over 600 metabolic QTL (mQTL). We further described and validated candidate genes associated with lipid content. Among them is a lipase-like protein (TomLLP) whose function was validatedin vivousing overexpression lines in tomato and knockout mutants in Arabidopsis. We also identified functions for three enzymes: a class III lipase (Sl-LIP8), a cyclopropane-fatty-acyl-phospholipid synthase (CFAPS1), and Lipoxygenase C (TomLoxC). By utilizing knockout lines forCFAPS1and CRISPR-Cas9 loss-of-function lines forSl-LIP8andTomLoxC, we demonstrated the functional importance of these enzymes in fruit lipid metabolism. Our study provides a comprehensive analysis of the tomato fruit lipidome and insights into key genes that shaped the natural variation in tomato lipid content and their links to flavor-associated volatile compounds.
Population connective field modeling reveals proto-retinotopic visual cortex organization in the prenatal human brain
Authors: Yoo So-Hyeon , Kieslinger Anne-Sophie , Skeide Michael A. 
Published: July 2024

AbstractThe visual space is sampled by cortical field maps in which nearby neuronal populations encode nearby locations of images received from the retina. Whether retinotopic cortical organization already emerges in the neonatal or even prenatal human brain is currently unknown. To answer this question in vivo, we applied population connective field modeling to 471 resting-state functional magnetic resonance imaging datasets ranging from prenatal to young adult age. We found topographically organized eccentricity and polar angle connectivity maps in V2 and V3 of the visual cortex as early as the 21st week of gestation. These results highlight that human proto-retinotopic cortical maps develop in the second trimester of pregnancy, predating visual experience.
Numerical simulation of RHIC polarized proton run 17 spin flipper experiments
Authors: Méot F. , Adams P. , Huang H. , Kewisch J. , Oddo P. , Roser T. 
Published: July 2024

RHIC nine-magnet spin flipper has been operated successfully during RHIC polarized proton Run 17, with 97% spin flip efficiency achieved. The results show the importance of mirror resonance removal, small spin tune spread, and proper spin flipper driving tune sweep speed. Detailed spin tracking simulations, based on a Lorentz force and Thomas-BMT differential equation numerical solver code for accuracy, have been carried out to understand the experimental results. Agreement within measurement accuracy is obtained at injection energy, 23.8 GeV. It is not as tight at 255 GeV, reasons for that are exposed. These measurements and numerical studies allow to determine the sensitivity of spin-flip efficiency to the dispersion slopes at the two Siberian snakes and to the ac dipole frequency sweep speed. They also provide guidance for future developments at BNL’s electron-ion collider.

Published by the American Physical Society
2024
Installed nacelle aerodynamics at cruise and windmilling conditions
Authors: Sánchez-Moreno Francisco , MacManus David , Tejero Fernando , Hueso-Rebassa Josep , Sheaf Christopher 
Published: July 2024

Purpose
The decrease in specific thrust achieved by Ultra-High Bypass Ratio (UHBPR) aero-engines allows for a reduction in specific fuel consumption. However, the typical associated larger fan size might increase the nacelle drag, weight and the detrimental interference effects with the airframe. Consequently, the benefits from the new UHBPR aero-engine cycle may be eroded. This paper aims to evaluate the potential improvement in the aerodynamic performance of compact nacelles for installed aero-engine configuration.

Design/methodology/approach
Drooped and scarfed non-axisymmetric compact and conventional nacelle designs were down selected from a multi-point CFD-based optimisation. These were computationally assessed at a set of installation positions on a contemporary wide-body, twin-engine transonic aircraft. Both cruise and off-design conditions were evaluated. A thrust and drag accounting method was applied to evaluate different aircraft, powerplant and nacelle performance metrics.

Findings
The aircraft with the compact nacelle configuration installed at a typical installation position provided a reduction in aircraft cruise fuel consumption of 0.44% relative to the conventional architecture. However, at the same installation position, the compact design exhibits a large flow separation at windmilling conditions that is translated into an overall aircraft drag penalty of approximately 5.6% of the standard cruise net thrust. Additionally, the interference effects of a compact nacelle are more sensitive to deviations in mass flow capture ratio (MFCR) from the nominal windmilling diversion condition.

Originality/value
This work provides a comprehensive analysis of not only the performance but also the aerodynamics at an aircraft level of compact nacelles compared to conventional configurations for a range of installations positions at cruise. Additionally, the engine-airframe integration aerodynamics is assessed at an off-design windmilling condition which constitutes a key novelty of this paper.
Examining the potential of virtual and augmented reality in enhancing tourism experiences
Authors: Shukla Vishal , Rana Sudhir , Prashar Sanjeev 
Published: July 2024

Purpose
This paper aims to explore the capabilities of virtual reality (VR) and augmented reality (AR) in enhancing the tourism experience and addressing physical travel constraints.

Design/methodology/approach
A survey was conducted among 412 tourists who had used VR and AR technologies for tourism purposes. Data was analysed using descriptive statistics, multidimensional scaling, multiple regression analysis, structural equation modelling and mediation and moderation analysis.

Findings
VR and AR enhance tourism via immersive experiences. They overcome traditional travel barriers, but accessibility concerns, like cost, persist. The perceived potential of these technologies strongly predicts future adoption, emphasising the need to highlight their immersive benefits.

Research limitations/implications
This study offers ground-breaking insights into VR and AR in tourism. It acknowledges inherent limitations in accessibility, with VR and AR technologies not being universally adoptable due to costs and complexity. Theoretically, the research enriches academic discourse by highlighting the pivotal role of perceived potential in technology adoption. It also delineates the intricate relationship between VR/AR experience, satisfaction, destination image and revisit intention.

Practical implications
The findings emphasise crafting immersive VR and AR experiences for differentiation. By integrating these technologies into strategic marketing, organisations can enhance customer satisfaction and provide richer destination experiences.

Social implications
The research underscores VR and AR’s potential to foster inclusive tourism, benefitting those with limitations. Additionally, promoting cultural exchange and sustainability, these technologies can drive societal harmony and contribute to economic growth through enriched tourism experiences.

Originality/value
This study stands out in its distinctive exploration of VR and AR in the tourism domain. The innovation lies in its comprehensive examination of the technologies’ immersive capabilities and their accessibility challenges. The value is accentuated by its insights, which bridge the gap between technological potential and its practical application in tourism.
Transforming digital resources into project management performance: a knowledge-based view
Authors: Jia Jianyao , Jiang Shan , Xiao Liang , Lu Fei 
Published: July 2024

PurposeThe adoption of emerging information and communication technologies in construction project teams has engendered numerous virtual spaces, characterized by communication visibility and content persistence. As a result, the knowledge exchanged in these virtual spaces serves as a team’s digital resources. However, the extant literature mostly takes a process-based approach to examine the impact of knowledge sharing, thus failing to fully comprehend the process of converting digital resources into performance, resulting in a gap in the literature.Design/methodology/approachThis study employs team resource-based theory to construct a theoretical model and develop hypotheses. Specifically, knowledge integration capability and team efficacy are hypothesized as two types of critical capabilities that mediate the links between knowledge sharing (quantity and quality) in virtual spaces and management performance. Data from 128 middle and senior construction project managers were collected to test the proposed theoretical model.FindingsThe results suggest that relationships between knowledge sharing (quantity and quality) and project management performance are both mediated by knowledge integration capability. Moreover, team efficacy could only partially translate knowledge sharing quantity into performance and couldn’t transform knowledge sharing quality into performance. Besides, knowledge integration is found to strengthen the link between knowledge sharing quantity and performance but weaken the relationship between knowledge sharing quality and performance.Originality/valueThis study explores how knowledge shared in virtual spaces could be leveraged for improving management performance in construction project teams. The findings in this study enhance the understanding of knowledge sharing in digital environments and afford important insights into transforming digital resources into performance within construction project teams.
Radio’s role in agricultural development: a review of broadcasting strategies for farmer education in South-West Nigeria
Authors: Shodipe Oluwafunmilayo Abimbola , Sanusi Bernice , Talabi Felix Olajide , Adelabu Omowale 
Published: July 2024

Purpose
This paper aims to assess the role of radio programmes in agricultural development and enhancing the capacity of farmers in Oyo and Ogun states, situated in the South-West region of Nigeria. Specifically, this study investigated Farm Radio International (FRI) radio broadcast strategies, their effectiveness and how they enhance the farmers’ knowledge, skills and practices.

Design/methodology/approach
The paper opted for a qualitative research design, using both interviews and focus group discussions to gather data from FRI radio partners and farmers.

Findings
Findings indicated that radio is effective in influencing the practices of farmers and helping them adopt new knowledge, ideas and skills. FRI partners use rural radio forum broadcasting strategy. Also, findings indicated that the most effective broadcasting strategy to reach the farmers with agricultural information is rural radio forum.

Practical implications
The paper includes implications for agricultural development organisations, providing a framework for monitoring and evaluating the impact of their communication interventions, helping ensure accountability and efficient use of funds.

Originality/value
This paper fulfils an identified need to investigate the broadcasting strategies that are most effective in reaching farmers with agricultural information and the influence of agricultural radio programmes on their farming practices.