bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of Oleyl Phosphate‐Modified TiO2/Poly(methyl methacrylate) Hybrid Thin Films for Investigation of Their Optical Properties
Authors: Fujita Masato , Idota Naokazu , Matsukawa Kimihiro , Sugahara Yoshiyuki 
Published: May 2015

TiO2 nanoparticles (NPs) modified with oleyl phosphate were synthesized through stable Ti–O–P bonds and were utilized to prepare poly(methyl methacrylate)‐ (PMMA‐) based hybrid thin films via the ex situ route for investigation of their optical properties. After surface modification of TiO2 NPs with oleyl phosphate, IR and 13C CP/MAS NMR spectroscopy showed the presence of oleyl groups. The solid‐state 31P MAS NMR spectrum of the product revealed that the signal due to oleyl phosphate (OP) shifted upon reaction, indicating formation of covalent Ti–O–P bonds. The modified TiO2 NPs could be homogeneously dispersed in toluene, and the median size was 16.1 nm, which is likely to be sufficient to suppress Rayleigh scattering effectively. The TEM images of TiO2/PMMA hybrid thin films also showed a homogeneous dispersion of TiO2 NPs, and they exhibited excellent optical transparency even though the TiO2 content was 20 vol%. The refractive indices of the OP‐modified TiO2/PMMA hybrid thin films changed higher with increases in TiO2 volume fraction, and the hybrid thin film with 20 vol% of TiO2 showed the highest refractive index (n = 1.86).
Abstract 3658: 90K attenuates the development of colitis-associated colorectal tumors through negative regulation of intestinal epithelial Toll-like receptor 4
Authors: Chung Ik-Joo , Hwang Jun-Eul , Lee Ji-Hee 
Published: May 2015

Abstract
Background:
Inflammation is a risk factor for colon cancer. TLR4 expression is upregulated in almost all colitis-associated cancer and dysplasia. The molecular mechanisms linking inflammation and colon carcinogenesis are incompletely understood. We found that tumor associated antigen 90K antagonized TLR4/NF-kB signaling pathway in colon cancer cells. We hypothesized that 90K is involved in TLR4 expression in colitis-induced colon carcinogenesis.
Methods:
The effect of 90K against TLR4 was analysed by cell cultures, NF-kB reporter assay, and immunoprecipitation. C57BL/6 mice were treated with 3% dextran sodium sulfate (DSS) for acute colitis model. Colitis was assessed by disease activity index (DAI) including weight loss, stool consistency and rectal bleeding, and histopathology.
Results:
90K interacts with TLR4, suppresses the NF-kB signal in the MYD88-dependent pathway that is major adaptor molecules in TLRs/NF-kB signal. Adenoviral 90K administration attenuated the severity of acute DSS-induced colitis as assessed by DAI and histopathologic scoring compared with the control group. 90K restored body weight loss and the severity of acute DSS colitis through the suppression of TLR4/MYD88/NF-kB signal.
Conclusions:
Tumor associated antigen 90K is involved in negative regulation of inflammatory signaling triggered by TLR4-induced NF-kB activation. The data suggest that 90K might thereby suppress proliferation and progression of colon cancers.
Citation Format: Ik-Joo Chung, Jun-Eul Hwang, Ji-Hee Lee. 90K attenuates the development of colitis-associated colorectal tumors through negative regulation of intestinal epithelial Toll-like receptor 4. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3658. doi:10.1158/1538-7445.AM2014-3658
Abstract 3773: Identification of ALDH1A3 as a driver of resistance to both low-dose metronomic and conventional cyclophosphamide chemotherapy in prostate cancer
Authors: Hoang Van C. , Chow Annabelle , Wong Amy , Sivanathan Lavarnan , Emmenegger Urban 
Published: May 2015

Abstract
Prostate cancer (PCa) is the most common cancer in North American males. Conventional, maximum tolerated dose (MTD) chemotherapy with cyclophosphamide (CPA) has been used in the past for PCa treatment, but has been replaced by docetaxel. However, renewed interest in CPA is emerging given its frequent use in low-dose metronomic (LDM) chemotherapy regimens known for their antiangiogenic properties. While therapeutic resistance limits the clinical utility of both LDM and MTD CPA, such resistance appears to occur through at least partially distinct mechanisms.
To investigate the molecular changes contributing to resistance formation, we have generated LDM and MTD CPA resistant PC-3 human prostate cancer cell variants (LCR and MCR, respectively), and corresponding control variants (NS), through in vivo passaging in mice. Using next-generation sequencing and gene expression analysis, we observed 453 differentially regulated genes in LCR vs NS, and 1141 genes in MCR vs NS. An intersecting set of 158 genes found to be differentially expressed in both resistant tumor cell lines was further characterized. The genes most up-regulated (including ALDH1A3, MAGEA2 and ELOVL2) and down-regulated (comprising FN1, IL8 and IGFBP3) were chosen for validation by qRT-PCR studies. We also undertook pathway analysis using the DAVID database and the Reactome FI Cytoscape Plugin.
Collectively, our studies revealed that glycolysis/gluconeogenesis, biosynthesis of unsaturated fatty acids and activated drug metabolism may contribute to resistance to both LDM and MTD CPA. In addition, numerous chemokine signaling pathway-related genes were found to be downregulated. Current studies are focusing on the role of ALDH1A3 in LDM and MTD CPA resistance. ALDH1A3 is amongst the most differentially regulated genes found in our analysis, and it has been associated with chemotherapy resistance, ‘stemness’ and aggressive tumor behaviour.
Despite different mechanisms of action, there are overlapping mechanisms of resistance to LDM and MTD CPA chemotherapy. If our studies confirm an essential role of ALDH13A in such resistance, this could be rapidly clinically translated by repurposing approved pharmacological ALDH inhibitors as anticancer agents.
Citation Format: Van C. Hoang, Annabelle Chow, Amy Wong, Lavarnan Sivanathan, Urban Emmenegger. Identification of ALDH1A3 as a driver of resistance to both low-dose metronomic and conventional cyclophosphamide chemotherapy in prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3773. doi:10.1158/1538-7445.AM2014-3773
Abstract 3777: Combining VELIPARIB (ABT-888) with temozolomide shows strong synergy when treating temozolomide-resistant and recurrent GBM cell lines
Authors: McDonald Kerrie , Nozue-Okada Kyoko , Khasraw Mustafa 
Published: May 2015

Abstract
Introduction: The survival trends for glioblastoma (GBM) patients have remained largely static, reflecting lack of improvement in the therapeutic options for patients. Less than 5% of newly diagnosed GBM survive more than 5 years. Standard treatment for GBM comprises of radiotherapy and temozolomide (TMZ) chemotherapy (chemoradiotherapy). Methylation of the promoter region of MGMT has been shown to be predictive of response to chemoradiotherapy. Approximately 30% of GBM are MGMT methylated. ABT-888 (Veliparib; Abbvie) is a Poly (ADP-ribose) polymerase (PARP) inhibitor that has been shown to enhance response of GBM to chemoradiotherapy in MGMT methylated patients. However, despite response (and lack of response in the case of MGMT unmethylated patients), recurrent GBM is refractory to treatment, occurring 2-3cm from the original resection and patient die within few months after recurrence. Herein we demonstrate the use of ABT-888 might be effective in patients who have recurrent GBM.
Methods: We tested ABT-888 alone and in combination with TMZ on low passage patient derived cell lines cultured from patients with recurrent GBM. We have used low passage patient derived cells including BAH and HW that are MGMT methylated. We also used U87, U251 and LN229 that are immortalized cells that are MGMT methylated. Of these lines, only U251 harbors a mutation in the binding domain of TP53. We also tested MGMT methylated low passage patient derived cell lines where TMZ resistance was selected for through continuous TMZ treatment of the cell line.
Results: Consistent with previous studies, monotherapy with ABT-888 was largely ineffective on all of the cell lines. We combined a low dose of ABT-888 (5μM) with a range of TMZ concentrations. Combination treatment was highly efficacious with sensitivity to TMZ improved by 30-70% when tested in 5 recurrent cell lines. All cell lines were MGMT unmethylated. We continuously treated 3 cell lines (2 MGMT methylated and 1 MGMT unmethylated) with TMZ until resistance was achieved. We found a response to the ABT-888/ TMZ combination was dramatic. Cells were 75% more sensitive to ABT-888/TMZ compared to retreatment with TMZ.
Conclusion: This novel strategy of combining ABT-888 with TMZ demonstrated synergistic antitumor activity for the treatment of relapsed and/or “chemo-resistant” GBM cell lines. Further investigation of this synergy has potential for rapid translation into clinical studies.
Citation Format: Kerrie McDonald, Kyoko Nozue-Okada, Mustafa Khasraw. Combining VELIPARIB (ABT-888) with temozolomide shows strong synergy when treating temozolomide-resistant and recurrent GBM cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3777. doi:10.1158/1538-7445.AM2014-3777
Black/White Disparities in Receipt of Treatment and Survival Among Men With Early-Stage Breast Cancer
Authors: Sineshaw Helmneh M. , Freedman Rachel A. , Ward Elizabeth M. , Flanders W. Dana , Jemal Ahmedin 
Published: May 2015

Purpose To examine the extent of black/white disparities in receipt of treatment and survival for early-stage breast cancer in men age 18 to 64 and ≥ 65 years. Patients and Methods We identified 725 non-Hispanic black (black) and 5,247 non-Hispanic white (white) men diagnosed with early-stage breast cancer from 2004 to 2011 in the National Cancer Data Base. We used multivariable logistic regression and calculated standardized risk ratios to predict receipt of treatment and a proportional hazards model to estimate overall hazard ratios (HRs) in black versus white men age 18 to 64 and ≥ 65 years, separately. Results Receipt of treatment was remarkably similar between blacks and whites in both age groups. Black and white older men had lower receipt of chemotherapy (39.2% and 42.0%, respectively) compared with younger patients (76.7% and 79.3%, respectively). Younger black men had a 76% higher risk of death than younger white men after adjustment for clinical factors only (HR, 1.76; 95% CI, 1.11 to 2.78), but this difference significantly diminished after subsequent adjustment for insurance and income (HR, 1.37; 95% CI, 0.83 to 2.24). In those age ≥ 65 years, the excess risk of death in blacks versus whites was nonsignificant and not affected by adjustment for covariates. Conclusion The excess risk of death in black versus white men diagnosed with early-stage breast cancer was largely confined to those age 18 to 64 years and became nonsignificant after adjustment for differences in insurance and income. These findings suggest the importance of improving access to care in reducing racial disparities in male breast cancer mortality.
‘Gotta keep the customer satisfied’: Puppeteers as director-surrogates in The Cabin in the Woods
Authors: Kooyman Ben 
Published: May 2015

Abstract
The postmodern horror comedy The Cabin in the Woods by Goddard (2012) depicts the heavily engineered ritual sacrifice of a group of college students on a recreational getaway. The chief orchestrators of this sacrifice – dubbed ‘puppeteers’ by the film’s protagonists – are Sitterson and Hadley, who in the film clearly inhabit the role of horror director-surrogates. While the parallels between their work and the film-making process have been widely noted, little has been said about what their on-screen representation actually has to say about horror film-makers. This ­article identifies four key premises on which the narrative hinges – that Sitterson and Hadley are journeyman directors rather than auteurs, that the directorial process is collaborative rather than auteur-centred, that horror directors must work with a prescribed number of finite formulas, and that their work is of considerable societal value – elucidating within The Cabin in the Woods a dialectical dialogue around the role, value and function of contemporary horror film authorship.
‘We are not who we are’: Lovecraftian conspiracy and magical humanism in The Cabin in the Woods
Authors: Lockett Christopher 
Published: May 2015

Abstract
Joss Whedon and Drew Goddard’s film The Cabin in the Woods (2012) conflates the two genres of slasher horror and conspiracy theory in such a way that articulates a trenchant critique of two totalizing grad narratives: religion and instrumental reason. Indeed, in the suturing of the story of a vast, technocratic conspiracy onto a Lovecraftian mythos about ancient gods demanding blood sacrifice, Cabin effectively dramatizes the central thesis of Dialectic of Enlightenment, by Theodor Adorno and Max Horkheimer (2002), insofar as blind adherence to rationality (manifested in the hyperadvanced technology of the conspiracy) is transformed into the madness of unreason. In marrying the supernatural and the technological, however, the film opens a space in which to articulate a humanist ethos, one best described as ‘magical humanism’.
When Dorian meets Holmes: An interview with Scott Handcock
Authors: Ue Tom 
Published: May 2015

Abstract
Completed shortly after the first series, this interview with Scott Handcock explores his creative process with The Confessions of Dorian Gray (2012-present), an ongoing audio-play series for the British company Big Finish Productions. Handcock, a writer, producer, and director based in Cardiff, has worked on Doctor Who for both AudioGo and Big Finish, and Bernice Summerfield (1998-present), Gallifrey (2004-present), and Dark Shadows (2006-present). Dorian Gray stars Alexander Vlahos as its titular character. In 2014, Handcock’s full-cast dramatization of Frankenstein, adapted by Jonathan Barnes, stars Arthur Darvill as Victor Frankenstein and Nicholas Briggs as the Creature. In this interview, we examine Handcock’s views about horror, and how our understandings of Wilde’s character and horror change as his story is set in different times and spaces.
Suicide, spectral politics and the ghosts of history in Elizabeth Kostova’s The Historian
Authors: Ambrisco Alan S. 
Published: May 2015

Abstract
This article examines Elizabeth Kostova’s 2005 Gothic novel The Historian, a vampire novel that undermines its fantasies of a wholly accessible past by repeated assurances that history is always fabricated. The novel in fact presents not just Dracula but the past itself as a ghostly amalgam of absence and presence. This spectralization of the past is a symptom of the narrator’s own traumatic past, and Dracula becomes a mask for a repressed family narrative of suicide. In Kostova’s handling, however, the Gothic also becomes a way of engaging larger societal traumas when the novel presents Dracula as a figure for the suicidal terrorist. This post-9/11 novel ultimately points to and represses the fears and complexities surrounding terrorism since 9/11, especially the overwhelming fear that US efforts at counter-terrorism are turning America into the very thing it is trying to fight.
‘I’ll give you television, I’ll give you eyes of blue, I’ll give you a man who wants to rule the world’: The commodification of women and the desire for the West in Takashi Miike’s Imprint
Authors: Green Amy M. 
Published: May 2015

Abstract
The theme of sacrificed identity resonates in popular film and television culture, and is especially exemplified in Imprint, a short film commissioned for the Masters of Horror series, which originally aired on Showtime from 2005 to 2007. Imprint was originally released in 2006, although due to its graphic content, the episode aired only in the United Kingdom and not in the United States. Despite the relative ubiquity of the eroticized Asian woman in western media culture, Imprint strikes a particular nerve in its exploration of these themes, one underscored by an unflinching use of graphic violence as a storytelling vehicle. Horror offerings often fail to garner much critical attention, or are dismissed out of hand strictly because of their genre. Extreme horror, often gathered inaccurately under a broad banner of ‘torture porn’ is especially prone to critical rejection. Imprint, as an exploration of cultural identity and loss, deserves just such critical attention.
Ideas of motherhood in Inside
Authors: Grafius Brandon R. 
Published: May 2015

Abstract
As Simone de Beauvoir and many others have discussed, western society too often assumes that the single goal of a woman’s life should be motherhood. These assumptions can be very damaging for women who choose to pursue other avenues instead of or in addition to motherhood. This article will use the writings of Beauvoir, Sarah Hrdy and Élisabeth Badinter to demonstrate how the recent horror film À l’Intérieur/Inside (2007), by Bustillo and Maury, examines these ideas by portraying a conflict between differing ideals of motherhood, each embodied as one of the film’s main characters. The article will argue that Inside understands modern constructions of motherhood as being damaging to society and destructive to mothers themselves.
Educating Edward and others: The issue of endless education in Meyer’s Twilight series
Authors: Crossen Carys 
Published: May 2015

Abstract
The issue of education within the Twilight series has received comparatively little critical attention to date, despite the importance of its high school setting in both the great romance between Bella and Edward, and the Cullen family’s repeated attendance of high school and college in order to blend in with the human population. There are other elements of education embedded throughout the series: the Cullens learning to resist the allure of human blood; Bella and Edward’s acquisition of self-knowledge via self-denial and suffering; and Bella’s learning to recognize herself as vampire. The purpose of this article is to explore these different types of education within the Twilight series, and in the first section to recognize their possibilities. The second section of the article will explore the limitations and problems presented by a seemingly endless education in Twilight. The article will address issues of education in relation to romance, identity and maturity, and whether or not the vampire characters of the Twilight series ever attain any kind of maturity.
Research cluster – ‘A Growing Global Darkness’: Dialectics of culture in Goddard’s The Cabin in the Woods
Authors: Blouin Michael J. 
Published: May 2015

Abstract
This article argues that Drew Goddard’s The Cabin in the Woods (2012) navigates between global and local strains emergent within the horror genre. Specifically, by scrutinizing the manner in which nightmares unique to American audiences are passed off as universal, the film offers a pointed critique of neo-liberalism. At the same time, Goddard’s film postulates that such fearful conditions may ultimately promote an alternative sense of community on the world stage. This shift has the potential to foster what theorists Michael Hardt and Antonio Negri label as the ‘monstrous multitude’.
801 - Evaluation of research strategies applied to Workplace Health Promotion
Authors: Gonçalo Camila Silva , Mialhe Fabio Luiz 
Published: May 2015

Introduction: Workplace Health Promotion (WHP) is conceptualized as a set of strategies and interventions to help people change their lifestyles and the environment where they develop their activities seeking to reach an optimum state of health. Objective: To present the results of a critical literature review about the more used research strategies and themes studied relation to health promotion at workplace. Methods: We conducted a bibliographical research on the American Journal of Health Promotion. This journal was chosen because it contained important studies about WHP. We only included observational and interventional studies published from 2005 to 2009. Results: Thirty-two articles were included in this research. The observational studies were the most cited design than interventions studies. The measurement procedures most used were questionnaire (n= 14; 44%) and telephone survey (n=6; 19%). The two themes more recurrent in the analyzed articles were: financial questions (n=9;28%) and smoking control (n=5;15,5%). The dental health (n=1;3%) and the stress management (n=1;3%) were the two themes less present among the articles analyzed. Final considerations: The WHP was exploited in various ways and the studies analyzed presented different types of evaluation. These data can support the planning and the actions with intersectoral and multidisciplinary approach when implementing strategies to WHP.Keyword: Health Promotion - Workplace - Occupational Health
Microabrasion Technique for Enamel with Fluorosis: A Case Report Utilizing Two Distinct Pastes
Authors: Ramos Carla Müller , Bim Júnior Odair , Borges Ana Flávia Sanches , Wang Linda , Mondelli Rafael Francisco Lia 
Published: May 2015

The technique of enamel microabrasion is considered an aesthetic alternative conservative and effective for stain removal or surface irregularities of the enamel and different materials or pastes can be used for this purpose Objetives: The objective of this study was to compare the efficiency of the technique of enamel microabrasion using two different pastes at removing hypoplastic stains by fluorosis. Methods: The female patient, 18 years, was submitted to enamel microabrasion, and in the right half of the maxilla was manipulated in the proportion of 1:1 by volume a paste of pumice (SSWhite) and 37% phosphoric acid (Etch Alpha, DFL), and in the left half of the maxilla used paste based on hydrochloric acid and 6.6% silicon carbide (Micropol, DMC Equipment Ltd.). In both hemi-arches was performed the same clinical protocol and repeated three times, by the application of 1.0 mm thickness of paste and realized the enamel microabrasion through mechanical friction with rubber cup at low speed for 10 seconds. Then, the teeth were polished with felt disc and diamond paste, and topical fluoride APF 1.23% for 3 minutes was applied. Results: The clinical outcome was similar for both hemi-arches, regardless of the used technique. The success in removing stains on tooth enamel is directly related to a correct diagnosis and accurate indication of microabrasion technique. Conclusions: It can be concluded that the two pastes used in the enamel microabrasion were effective for removing intrinsic stains from fluorosis, with similar results and with the re-establishment of aesthetics of the teeth involved.