bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification and site-specific analysis of co-occupied N- and O-glycopeptides
Authors: Chongsaritsinsuk Joann , Rangel-Angarita Valentina , Mahoney Keira E. , Lucas Taryn M. , Enny Olivia M. , Katemauswa Mitchelle , Malaker Stacy A. 
Published: July 2024

AbstractProtein glycosylation is a complex post-translational modification that is generally classified as N- or O-linked. Site-specific analysis of glycopeptides is accomplished with a variety of fragmentation methods, depending on the type of glycosylation being investigated and the instrumentation available. For instance, collisional dissociation methods are frequently used for N-glycoproteomic analysis with the assumption that one N-sequon exists per tryptic peptide. Alternatively, electron-based methods are indispensable for O-glycosite localization. However, the presence of simultaneously N- and O-glycosylated peptides could suggest the necessity of electron-based fragmentation methods for N-glycoproteomics, which is not commonly performed. Thus, we quantified the prevalence of N- and O-glycopeptides in mucins and other glycoproteins. A much higher frequency of co-occupancy within mucins was detected whereas only a negligible occurrence occurred within non-mucin glycoproteins. This was demonstrated from analyses of recombinant and/or purified proteins, as well as more complex samples. Where co-occupancy occurred, O-glycosites were frequently localized to the Ser/Thr within the N-sequon. Additionally, we found that O-glycans in close proximity to the occupied Asn were predominantly unelaborated core 1 structures, while those further away were more extended. Overall, we demonstrate electron-based methods are required for robust site-specific analysis of mucins, wherein co-occupancy is more prevalent. Conversely, collisional methods are generally sufficient for analyses of other types of glycoproteins.Abstract Figure
Modifiable Risk Factors for Stroke, Dementia, and Late-Life Depression: A Systematic Review and DALY Weighted Risk Factors for a Composite Outcome
Authors: Senff Jasper R. , Tack Reinier W.P. , Mallick Akashleena , Gutierrez-Martinez Leidys , Duskin Jonathan , Kimball Tamara N. , Chemali Zeina , Newhouse Amy , Kourkoulis Christina , Rivier Cyprien , Falcone Guido J , Sheth Kevin N , Lazar Ronald M , Ibrahim RN Sarah , Pikula Aleksandra , Tanzi Rudolph E. , Fricchione Gregory , Brouwers H. Bart , Rinkel Gabrël J.E. , Yechoor Nirupama , Rosand Jonathan , Anderson Christopher D. , Singh Sanjula D. 
Published: July 2024

AbstractBackgroundAt least 60% of stroke, 40% of dementia, and 35% of late-life depression (LLD) are attributable to modifiable risk factors, with great overlap due to a shared underlying pathophysiology. This study aims to systematically identify overlapping risk factors for these diseases and calculate their relative impact on a composite outcome.MethodsA systematic literature review was performed in Pubmed, Embase, and PsycInfo, between January 2000 and September 2023. We included meta-analyses reporting effect sizes of modifiable risk factors on the incidence of stroke, dementia, and/or LLD. The most relevant meta-analyses were selected, and Disability Adjusted Life Year (DALY) weighted beta-coefficients were calculated for a composite outcome. The beta-coefficients were then normalized to assess relative impact.ResultsOur search yielded 182 meta-analyses meeting the inclusion criteria, of which 59 were selected to calculate DALY-weighted risk factors for a composite outcome. Identified risk factors included alcohol use (normalized beta-coefficient highest category: -20), blood pressure (87), BMI (42), fasting plasma glucose (57), total cholesterol (14), leisure time cognitive activity (-54), depressive symptoms (34), diet (27), hearing loss (35), kidney function (60), pain (25), physical activity (-34), purpose in life (-30), sleep (44), smoking (58), social engagement (32), and stress (32).DiscussionThis study identified overlapping modifiable risk factors and calculated the relative impact of these factors on the risk of a composite outcome of stroke, dementia, and LLD. These findings could guide preventative strategies and serve as an empirical foundation for future development of tools that can empower people to reduce their risk of these diseases.FundingUS National Institutes of Health and American Heart Association.
Associations between social network characteristics and COVID-19 vaccination intention – the SaNAE study
Authors: Steijvers Lisanne CJ , van Bilsen Céline JA , Brinkhues Stephanie , Stutterheim Sarah E , Crutzen Rik , Ruiter Robert AC , Hoebe Christian JPA , Dukers-Muijrers Nicole HTM 
Published: July 2024

ABSTRACTBackgroundSocial networks, our social relationships, play a role in the spread of infectious diseases but also in infection prevention behaviors such as vaccination. Here, we aimed to assess which individual, interpersonal (social network characteristics), community and societal factors are associated with COVID-19 vaccination intention during the second wave of the COVID-19 pandemic.MethodsThe cross-sectional study utilized online questionnaire data collected between August and November 2020 in community-dwelling adults aged 40 years and older. COVID-19 vaccination intention was measured by assessing whether respondents were willing to receive a COVID-19 vaccination if the vaccines became available. At the time of data collection, vaccines were still in development. Associations between individual (sociodemographic variables, health, health concerns), interpersonal (social network characteristics including structure, function, and quality), community (social and labor participation) and societal factors (degree of urbanization), and the outcome variables COVID-19 vaccination intention (yes vs no, yes vs unsure, unsure vs no) were assessed in stepwise multivariable regression analyses.ResultsOf all participants (N=3,396), 59% reported a positive intention to vaccinate against COVID-19, 35% were unsure, and 6% had no intention. Men, individuals of older age, those with a college or university degree, and those concerned about their personal and family health were more likely to have the intention to vaccinate. Interpersonal factors associated included having a larger network size (social network structure) and a larger proportion of informational and emotional supporters (social network function). Living outside of urban areas, a societal factor was also associated with the intention to vaccinate.ConclusionIn this study, we determined key characteristics of COVID-19 vaccination intention. Health promotion and vaccination communication strategies should focus not only on individual factors but also incorporate the social environment. Our findings highlight the importance of organizing social networks to mobilize social support for pandemic preparedness.
Perceived levels of mental health service accessibility and associated factors among psychiatric outpatients in Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2024
Authors: Ayenew Surafel , Haile Kibrom , Leyew Weldehawariat , Abate Solomon , Chaka Asrat 
Published: July 2024

AbstractBackgroundWe live in multifaceted, dynamic and interconnected world in which the importance of physical, mental, and social wellbeing has not been well emphasized. Given the intricate nature of life, it is clear that mental health is essential to the welfare of people, communities, nations, and the entire planet. The main tactic to address unmet mental health needs has been to integrate psychiatric treatment into primary care, however this approach has been ineffective, and psychiatric services have been concentrated in Ethiopia and other major cities in sub-Saharan Africa. This study aimed to assess the perceived levels of mental health service accessibility and associated factors among psychiatric outpatients at Amanuel mental specialized hospital, Addis Ababa, Ethiopia, 2024.ObjectiveTo assess the perceived levels of mental health service accessibility and associated factors among psychiatric outpatients at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2024.MethodsInstitution-based cross-sectional study were employed from 03 January, to 03 February 2024. A total of 415 participants were participated. A systematic sampling technique was used. Binary logistic regression model was fitted to identify the factors associated with service accessibility. Adjusted odds ratio (AOR) with 95% confidence interval (CI) and p-value less than 0.05 during multivariable logistic regression were used to declare the factors associated with the outcome variable.ResultsThe perceived level of mental health service accessibility was 10.4%; 95% CI: (7.5%, 25. 9%).Service accessibility was associated with urban resident [(AOR = 3.563, 95% CI: (1.065, 11.9155)], and Medication access [(AOR = 2.604, 95%CI: (1.220, 5.555)].Conclusions and recommendationsThe study observed that the prevalence of perceived service accessibility was found to be low in this study. Availability of medication and urban resident are the factors associated with perceived level of mental health service accessibility. There is a need to have proper coordination and cooperation among various mental health service providers.
Gender-specific associations of adverse childhood experiences (ACEs) and schizotypal traits – an observational study in healthy young adults
Authors: Christina Kirchhoff , David Riedl , Maria-Sophie Rothmund , Katharina Hüfner , Gabrielle Scantamburlo , Felix Scholtes , Marius Brandenberg , Anna Steiner , Noemi Dannecker , Werner Surbeck , Philipp Homan 
Published: July 2024

AbstractBackground and HypothesesSchizotypy is a complex model containing a broad spectrum of personality traits that can be observed in the general population as well as in psychiatric patients. There is compelling evidence that Adverse Childhood Experiences (ACEs) are correlated with schizotypal traits in healthy individuals. We hypothesize that associations between specific forms of abuse and distinct schizotypal traits will demonstrate gender-specific differences.Study DesignThe present study relies on a dataset designed and collected for the VELAS-study (VELAS: Ventral language stream in schizophrenia with regard to semantic and visuo-spatial processing anomalies) in Zurich, Switzerland. Young adults completed an online questionnaire which included the Childhood Trauma Questionnaire (CTQ) and the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE). To test individual associations, gender-specific linear regression models were calculated.Study ResultsA total of 597 healthy young adults completed the online questionnaire. Gender-specific linear regression models revealed strong associations of emotional abuse with all schizotypal traits in both sexes with stronger effect sizes for male subjects. In men, sexual abuse was associated with Unusual Experiences, while in women it was associated with Disorganisation. Emotional neglect showed an association with Introvertive Anhedonia in both genders, with stronger effect sizes for male than female participants. Physical neglect exhibited an association with Introvertive Anhedonia solely in male subjects.ConclusionsOur gender-specific results give a deeper insight into associations of ACEs with schizotypal traits and serve as a puzzle piece in understanding risk constellations in the development of schizophrenia spectrum disorders.
Unearthed Novel Molecular Phenotypes and Potential Therapeutic Targets in Esophagogastric Adenocarcinoma
Authors: Windon Annika , Al Assaad Majd , Hadi Kevin , Mendelson Nicole , Hissong Erika , Deshpande Aditya , Tranquille Marvel , Mclee Justin , Patel Minal , Medina-Martínez Juan S. , Chiu Kenrry , Manohar Jyothi , Sigouros Michael , Ocean Allyson J. , Sboner Andrea , Jessurun José , Elemento Olivier , Shah Manish , Mosquera Juan Miguel 
Published: July 2024

AbstractBackgroundEsophagogastric adenocarcinoma demands a deeper molecular understanding to advance treatment strategies and improve patient outcomes. Here, we profiled the genome and transcriptome landscape of these cancers, explored molecular characteristics that are invisible to other sequencing platforms, and analyzed their potential clinical ramification.MethodsOur study employed state-of-the-art analyses of whole genome and transcriptome sequencing on 52 matched tumor and germline samples from 47 patients, aiming to unravel new therapeutic targets and deepen our understanding of these cancers’ molecular foundations.ResultsThe analyses revealed 88 targetable oncogenic mutations and fusions in 62% of the patients, and further elucidated molecular signatures associated with mismatch repair and homologous recombination deficiency. Notably, we identifiedCDK12-type genomic instability associated withCDK12fusions, novelNTRK, NRG1, ALK,andMETfusions, and structural variants in relevant cancer genes likeRAD51B.ConclusionsOur findings demonstrate the power of integrative whole genome and transcriptome sequencing in identifying additional therapeutic targets, supporting a promising path for precision medicine in treating esophagogastric adenocarcinoma.
Magnetotransport of fluxoids in intermediate-phase type-II superconducting NbN thin films around
Tc
Authors: Kanduri Sai Vaishnavi , Vegesna Sahitya V. , Bürger Danilo , Li Zichao , Born Detlef , Schmidt Heidemarie 
Published: July 2024

The mixed state transport properties of type-II superconductors are strongly influenced by the dynamic behavior of quantized magnetic fluxoids around the critical temperature (Tc), where a combination of normal and superconducting properties is exhibited. To understand the mixed state transport properties of type-II superconducting NbN ultrathin films (2D) we measured sheet resistance (RxxM) and Hall resistance (RxyM) of a 5-nm-thick NbN film around Tc (10.75 K) at temperatures 10.40, 10.68, and 10.77 K. Hall resistance (HR) was measured in external out-of-plane and in-plane magnetic fields up to 6 T, using 100 µA and 1 mA driving current in Van der Pauw geometry. The electric field of applied bias and Lorentz force of applied external magnetic field causes a movement of the normal conducting electrons within each fluxoid. The moving fluxoids cause dissipation and generation of Hall voltage. We developed a macroscopic analysis of the Hall resistance arising from fluxoids, to advance the differentiation between dissipating current and superconducting currents in type-II superconductors at Tc. We have extracted the number of normal conducting carriers per fluxoid and areal density and mobility of the fluxoids in dependence on the external magnetic field. This differentiation provides valuable insights into the dissipation mechanisms observed during transport measurements, e.g., after localized heating due to single photon absorption in nanostructured type-II superconductors. Furthermore, the developed macroscopic analysis of Hall resistance of fluxoids shows promising potential for investigating the fundamental aspects of fluxoid-defect interactions in type-II superconductors.

Published by the American Physical Society
2024
Research on relative reachable domain in target orbit for maneuvering spacecraft
Authors: Li Xuehua , Zhang Lei 
Published: July 2024

Purpose
Lots of successful space missions require that the maneuvering spacecraft can reach the target spacecraft. Therefore, research on relative reachable domain (RRD) in target orbit for maneuvering spacecraft is particularly important and is currently a hot-debated topic in the field of aerospace. This paper aims at analyzing and simulating the RRD in target orbit for maneuvering spacecrafts with a single fixed-magnitude impulse and continuous thrust, respectively, to provide a basis for analyzing the feasibility of spacecraft maneuvering missions and improving the design efficiency of spacecraft maneuvering missions.

Design/methodology/approach
Based on the kinematics model of relative motion, RRD in target orbit for maneuvering spacecraft with a single fixed-magnitude impulse can be calculated via analyzing the relationship between orbital elements, position vector and velocity vector of spacecrafts, and relevant studies are introduced to compare simulation results for the same case and validate the method proposed in the paper. With analysis of the dynamic model of relative motion, the calculation of RRD in target orbit for maneuvering spacecraft with continuous thrust can be transformed as the solution of the optimal control problem, and example emulations are carried out to validate the method.

Findings
For the case with a single fixed-magnitude impulse, simulation results show preliminarily that the method is in agreement with the method in Ref. (Wen et al., 2016), which treats the same case and thus is plausibly correct and feasible. For the case with continuous thrust, analysis and simulation results confirm the validity of the proposed method. The methods based on relative motion in this paper can efficiently determining the RRD in target orbit for maneuvering spacecraft.

Originality/value
Both theoretical analyses and simulation results indicate that the method proposed in this paper is comparatively simple but efficient for determine the RRD in target orbit for maneuvering spacecraft swiftly and precisely.
Accuracy compensation method with the combined dissimilar measurement devices for enhanced measurement quality: a digital aircraft assembly technology
Authors: Miah Md Helal , Singh Chand Dharmahinder , Malhi Gurmail Singh 
Published: July 2024

Purpose
The pivotal aspect of aircraft assembly lies in precise measurement accuracy. While a solitary digital measuring tool suffices for analytical and small surfaces, it falls short for extensive synthetic surfaces like aircraft fuselage panels and wing spars. The purpose of this study is to develop a “combined measurement method” (CMM) that enhances measurement quality and expands the evaluative scope, addressing the limitations posed by singular digital devices in meeting measurement requirements across various aircraft components.

Design/methodology/approach
The study illustrated the utilization of the CMM by combining a laser tracker and a portable arm-measuring machine. This innovative approach is tailored to address the intricate nature and substantial dimensions of aircraft fuselage panels. The portable arm-measuring machine performs precise scans of panel components, while common points recorded by the laser tracker undergo coordinate conversion to reconstruct the fuselage panel’s shape. The research outlines the CMM’s measurement procedure and scrutinizes the data processing technique. Ultimately, the investigation yields a deviation vector matrix and chromatogram deviation distribution, pivotal in achieving enhanced measurement precision for the novel CMM device.

Findings
The use of CMM noticeably enhances fuselage panel assembly accuracy, concurrently reducing assembly time and enhancing efficiency compared to conventional measurement systems.

Practical implications
The research’s practical implication lies in revolutionizing aircraft assembly by mitigating accuracy issues through the innovative digital CMM for aircraft synthetic structure type product (aircraft fuselage panel). This ensures safer flights, reduces rework and enhances overall efficiency in the aerospace industry.

Originality/value
Introducing a new aircraft assembly accuracy compensation method through digital combined measurement, pioneering improved assembly precision. Also, it enhances aerospace assembly quality, safety and efficiency, offering innovative insights for optimized aviation manufacturing processes.
ChatGPT in education: unveiling frontiers and future directions through systematic literature review and bibliometric analysis
Authors: Amarathunga Buddhini 
Published: July 2024

PurposeThis is a dual-focused study that anticipates qualitatively and quantitatively examining the literature on the recently initiated revolutionizing concept of ChatGPT in education by performing a Systematic Literature Review (SLR) and bibliometric analysis. Current study analyzed eight research questions: (1) the main information and annual scientific publications on ChatGPT in education, (2) the pioneer authors and collaborative authors exploring ChatGPT in education, (3) the authors' productivity through Lotka’s Law of Authors’ Scientific Productivity, (4) the most pertinent sources on ChatGPT in education and how are sources clustered through Bradford’s Law of Scattering, (5) the most related, cited countries and the nature of international collaborations exploring ChatGPT in education, (6) the most relevant publications exploring ChatGPT in education, (7) the most occurring and trending keywords in the empirical studies on ChatGPT in education, and (8) the themes and areas for future investigations on ChatGPT in education.Design/methodology/approachThe current study was designed as a SLR and bibliometric analysis, extracting articles from the Scopus database and utilizing both Biblioshiny and VOSviewer software for advanced scientific mapping and visualizations via quantitative and qualitative analysis approaches.FindingsThe results indicated that ChatGPT in education is a progressively evolving worldwide concept generating 45 scientific publications from 2023 to 2024 (May). The USA, China, and Indonesia are the most productive countries that have published articles on ChatGPT in education. The education systems, AI, students, educational computing, human experiments, teaching, educational status, chatbots, generative AI, academic integrity, educational technology, worldwide education, and technology acceptance are the pertinent future directions in the field of ChatGPT in education.Originality/valueThe analysis’s outcomes will enhance the area of study with theoretical and practical implications and benefit students, teachers, policymakers, regulators of educational and higher educational sectors, government, and the general public worldwide with effective utilization of ChatGPT in education.
A conceptual exploration of researcher positionality and critical reflexivity in disaster research through the lens of Bourdieu
Authors: Uekusa Shinya 
Published: July 2024

PurposeThe purpose of this paper is to deconstruct the current discourse on researcher positionality in disaster research and it aims to enhance disaster researchers’ reflexivity, using Bourdieu’s capital, field and habitus theories.Design/methodology/approachThis conceptual paper relies on secondary literature from empirical and theoretical works and incorporates critical self-reflection from author’s own research experience.FindingsAs Bourdieu would argue, one’s habitus is interactive and responsive to contexts (field and other agents’ habitus and capital), thus reflexivity requires more than the acknowledgement of one’s ascribed and achieved social characteristics. Bourdieu’s theories help disaster researchers enhance their reflexivity and better understand the nature of researcher positionality: contextual, dynamic and negotiated.Originality/valueThis research provides a critical and theoretical discussion of researcher positionality in disaster research. Drawing from Bourdieu’s theories, researcher positionality can be framed in relation to not only researcher’s structurally differentiated insider–outsider status but also how interactions with the research participants and contexts in which the research is conducted influence that positionality.