bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, in silico and biodistribution studies of a novel 47Sc-radiolabeled α-amino acid ester derivative attached to pyrazine and tetrazole rings for tumor targeted radiotherapy
Authors: Gizawy Mohamed A. , Shamsel-Din Hesham A. , El-Tahawy Mohsen M. T. , Ibrahim Ayman A. 
Published: July 2024

Abstract
Recently, tumor-targeted radionuclide therapy has gained much recognition for the treatment of metastasized cancer. There is a growing interest in using the theranostic radionuclide 47Sc, owing to its excellent chemical and nuclear properties. However, the available chelating agents require a relatively high temperature for their radiolabeling, which could denature biomolecules. The aim of the present study is to synthesize a dipeptide agent that forms a thermodynamically more stable complex with 47Sc at room temperature. A novel α-amino acid ester derivative attached to pyrazine and tetrazole heterocyclic rings has been prepared by the azide coupling method. Different spectroscopic methods (FT-IR, 1H NMR, and mass spectra) were used for characterization of the target compound. The newly synthesized dipeptide was radiolabeled with 47Sc, and a high radiochemical yield of 98.5 ± 1.5 % and in vitro serum stability up to 72 h were attained at room temperature within 20 min. The quantum chemical calculations at B3PW91/6-31G(d) level were employed to establish the molecular structure of the dipeptide and its complexation with 47Sc. The selectivity of 47Sc-dipeptide toward localization in tumor cells was performed by molecular docking on different receptors in addition to in vivo biodistribution on solid tumor-bearing mice. A high T/NT ratio of 8.16 was obtained after 4 h p.i, suggesting that this complex could be used as a potential cancer theranostic agent.
On the goals of theoretical linguistics
Authors: Culicover Peter W. , Varaschin Giuseppe 
Published: July 2024

Abstract
We review some of the main goals of theoretical linguistics in the tradition of Generative Grammar: description, evolvability and learnability. We evaluate recent efforts to address these goals, culminating with the Minimalist Program. We suggest that the most prominent versions of the Minimalist Program represent just one possible approach to addressing these goals, and not a particularly illuminating one in many respects. Some desirable features of an alternative minimalist theory are the dissociation between syntax and linear order, the emphasis on representational economy (i.e. Simpler Syntax) and an extra-grammatical account of non-local constraints (e.g. islands). We conclude with the outline of an alternative minimalist perspective that we believe points to more satisfactory accounts of the observed phenomena.
Social meaning
Authors: Eckert Penelope 
Published: July 2024

Abstract
In recent decades, semanticists moving beyond truth conditional meaning and sociolinguists moving beyond correlations with social structural categories have developed a shared interest in what is commonly called social meaning. This raises the possibility of a comprehensive theory of meaning, moving away from the exclusively propositional model of grammar, and treating language not just as structure but as practice. The paper briefly traces the emergence of social meaning in sociolinguistics, and discusses some issues involved in a broader theory, such as what counts as social meaning, the notions of context and intention, and the need to adopt the Peircian sign.
Reflections on the grammatical view of scalar implicatures
Authors: Xue Bo , Pan Haihua 
Published: July 2024

Abstract
This paper first introduces the standard recipe for deriving quantity implicatures in the neo-Gricean framework. Then, it compares this pragmatic stance with the grammatical view that argues that scalar implicatures should be generated via an operator in syntax. After showing how the grammatical view can derive canonical scalar implicatures, motivations for this view are discussed which include embedded implicatures, obligatory scalar implicatures concerning the Hurford Constraint, and Free Choice inferences. This paper finally examines basic tenets of the grammatical view and points out three potential problems for this approach.
Synthesis and structural characterization of supramolecular cocrystals of [(4-cyano-1-methylpyridinium)2-(18-crown-6)] diiodide
Authors: Balasubramanian Venkataraman , Kalpana Sukumar , Ibragimov Aziz , Balakrishnan Chellakarungu 
Published: July 2024

Abstract
This study focuses on synthesizing and characterizing supramolecular cocrystals derived from 4-cyano-1-methylpyridinium iodide and 18-crown-6. The synthesis employed a solvent evaporation technique, followed by a thorough structural analysis utilizing XRD methods. The compound’s purity is confirmed by powder XRD analysis, while single-crystal XRD confirms its triclinic system packing with a centrosymmetric space group (

P

1
‾

$P\overline{1}$

). The findings unveiled the emergence of unique cocrystals characterized by distinct molecular configurations supported by hydrogen bonding and ion-dipole interactions. Through diffuse reflectance spectral measurements, the direct band gap energy was assessed at 2.36 eV. Thermogravimetric analysis was utilized to evaluate the thermal properties of the compound across varying temperatures. The compound’s elemental composition and surface morphology were analyzed through investigations using EDS and SEM.
Sistema prisional e migrações: os instrumentos jurídicos do Brasil e do Uruguai
Authors: Núñez Almeida Letícia , Dutra Fernández Thais , Garibaldi Rivoir Cecilia 
Published: July 2024

O presente estudo tem como objetivos principais apresentar algumas interfaces, proximidades e distâncias entre as políticas migratórias e as políticas penitenciárias, e nessa paisagem, analisar comparativamente os instrumentos jurídicos dos Estados brasileiro e uruguaio. Buscando apresentar de forma esquematizada e didática as legislações vigentes que regem as situações de pessoas estrangeiras em conflito com a lei no Brasil e no Uruguai. Para tanto utilizou-se do método descritivo e comparativo, identificando peculiaridades e dificuldades na aplicação das normas nos dois países.AbstractThe main objectives of this study are to present the main aspects, similarities and divergences between Brazilian and Uruguayan migration and penitentiary policies and to compare legal instruments from both countries. We aim to present and summarize current laws that govern the status of foreigners in conflict with the law in Brazil and in Uruguay. Therefore, we apply descriptive and comparative methods seeking to identify peculiarities and obstacles to the application of the law in both countries.Keywords: prison system; migratory policies; legislation of Brazil and Uruguay.
Transcatheter Treatment Options for Functional Mitral Regurgitation: Which Device for Which Patients?
Authors: Tom Stephanie K , Kalra Kanika , Perdoncin Emily , Tully Andy , Devireddy Chandan M , Inci Errol , Greenbaum Adam , Grubb Kendra J 
Published: July 2024

Mitral regurgitation is the most common valvular disease in the developed world, with approximately 24.2 million people being affected worldwide and a higher prevalence in older age groups. Surgical correction of degenerative mitral regurgitation is the standard of care and can restore cardiac function and provide a lasting result, especially when the mitral valve can be repaired. Secondary mitral regurgitation, or functional mitral regurgitation (FMR), describes atrial or ventricular factors leading to poor coaptation of an otherwise non-diseased valve. For FMR, traditional surgery has not produced the same level of benefit. Transcatheter mitral repair and replacement techniques that mimic surgical correction are under investigation. Transcatheter edge-to-edge repair is the only approved catheter-based therapy for FMR in the US. Here, the transcatheter treatment options for FMR are reviewed.
Levels of emotional intelligence and student engagement in Eritrean college students
Authors: Gebregergis Werede Tareke , Beraki Furtuna , Michael Mulubrhan , Ahmedin Munira , Debesay Nahom , Atoshm Tsega , Tekleberhan Wizdan , Kovacs Karolina Eszter , Csukonyi Csilla 
Published: July 2024

AbstractThe study sought to explore the levels of emotional intelligence and academic engagement among college students, which has not been extensively represented in the existing literature within the Eritrean higher educational context. The study comprised a sample of 119 senior Asmara College of Education students selected through the convenience sampling strategy. The Self-Report Emotional Intelligence Test and Student Engagement Scale were employed to assess the levels of emotional intelligence and student engagement of the participants. Frequency distribution, Pearson-moment correlation, and independent sample t-tests were conducted for data analysis. A significance level of 0.05 was selected to determine statistical significance when testing the relationships of emotional intelligence and engagement with demographic variables. The findings of the study revealed that most students exhibited moderate to high levels of emotional intelligence and academic engagement. The independent sample t-tests indicated that female students tended to have higher levels of emotional intelligence and also reported higher behavioral engagement compared to male students. Regarding the program of study, students from the Department of Psychology and Educational Administration showed higher levels of emotional intelligence than Science education students. Conversely, Science Education students displayed greater cognitive engagement compared to those in Psychology and Educational Administration. Age was found to have a significant association with academic engagement, with older students demonstrating higher levels compared to younger students. However, the Pearson product-moment results demonstrated that significant emotional intelligence scores did not significantly differ across different age groups. The findings are expected to offer significant insights into student engagement and emotional intelligence within the context of higher education. Moreover, this study can offer practical guidance for college communities on fostering students' levels of engagement in learning and emotional skills.
The practical implementations of axes in the design of a systematic office layout
Authors: Abu-Lail Dana Maher Ayoub , Zoltán Erzsébet Szeréna 
Published: July 2024

AbstractIn the ever-changing realm of the contemporary workplace, adaptability and flexibility have emerged as crucial attributes for office buildings. The method of axes system design, in conjunction with modular structures, fosters a workspace that can seamlessly adapt to the evolving needs of offices. This system embodies a comprehensive approach to office design, emphasizing the integration of four important principles: modularity, adaptability, interconnectedness, and flexibility. The modular nature of the structural axes design allows for swift and cost-effective adjustments, facilitating customer needs. The dynamism of this system ensures that office spaces are in a perpetual state of evolution, reflecting the changing dynamics of the contemporary workplace as to be shown in this paper.
Collision and contiguity in the transformation of Prishtina's urban form
Authors: Jashanica Kaltrina , Dullinja Ejup 
Published: July 2024

AbstractThe work focuses in architectural dimension of urban form, by confronting the plans of three neighborhoods in Prishtina that represent potentially three main urban paradigms of the last decades in city's urban transformation. The study aims to unfold the main elements, confront them, and expose to possible transformation. The work progressively decomposes each case into basic components and deductively to their minimal unit.The research, through interpretation and graphic illustrations, analyzes the three plans by layers: basic elements and their relational modalities, urban matrix, open space character and composing minimal units. The process will identify the main components, and their generic potentiality to be considered as future inputs in city's development.
Vivir habitando “lugares”. El lugar de la memoria en la razón viviente poéticapictórica de María Zambrano
Authors: López Sáenz María Carmen 
Published: July 2024

En este artículo procederemos, en primer lugar, a clarificar las características de la razón poética de M. Zambrano en relación con la vida, la historia y, por ende, con la razón vital-histórica de Ortega y Gasset. A continuación, mostraremos de qué modo la primera incluye la poiésis de la pintura. Veremos entonces la relación que la “razón poética-pictórica” guarda con la memoria, así como el tipo de memoria que la filósofa reivindica en comparación con uno de los filósofos a los que leyó desde su juventud: Henri Bergson. Al hilo de esta exposición analizaremos el sentido que la pensadora le otorga al “lugar”, con el objeto de descifrar el título de su obra “Algunos lugares de la pintura”. Solo así lograremos entender la preocupación zambraniana por abrir lugares espaciotemporales habitables en los que detenerse a contemplar. Nos preguntaremos en nuestra conclusión si esto es todavía posible en la era de la información.
El concepto de prudencia en la antropología kantiana Horizontes y técnicas para una vida buena
Authors: Cifuentes Yarce Jesús David 
Published: July 2024

Este artículo explora la Antropología en sentido pragmático y las Lecciones de Antropología con el fin de buscar las reglas de la prudencia, los horizontes y las técnicas que Kant propuso para saber vivir consigo mismo y con los otros. Estas técnicas las dirigió a los modos del pensar (Denkungsart), ya que en el pensamiento es donde se manifiesta la voz de la razón y en la razón todos los seres humanos tienen voz; por tanto, también en ella reside la posibilidad de construir juntos un mundo común. Por otra parte, se estudiará cómo la prudencia es la cura del egoísmo -el cual es el mayor obstáculo para el cosmopolitismo y para la construcción de una vida vinculada-, pues es la base de una buena vida.
Cuerpos como fronteras heridas, intervenidas y resistentes: la enfermedad y el buen vivir
Authors: Chamorro Muñoz Alicia Natali 
Published: July 2024

El presente artículo pretende proponer una reflexión sobre la vida buena desde la filosofía de la enfermedad. Asume que para entender los desafíos que la enfermedad suscita a nivel social y político vale la pena concebir el cuerpo como frontera. Esta idea de frontera, presentada por Anzaldúa, permite comprender tres relaciones esenciales: la particular comprensión de identidad del sujeto enfermo que en suma complejiza toda forma de identidad personal; la relación entre tecnología y cuerpo en la condición de una vida buena desde la perspectiva posthumanista, y, finalmente, la comprensión de una biopolítica que, al asumir la radicalidad de la relación entre enfermedad y salud, reconduzca a nuevas prácticas sociales de la vida buena.
Política a contratiempo. Apuntes para un futuro posible en el marco de la sociedad del rendimiento (Leistungsgesellschaft)
Authors: Botero-Bernal Andrés , Aguirre-Román Javier Orlando , Almeyda-Sarmiento Juan David 
Published: July 2024

Esta investigación expone cómo el tiempo, en cuanto categoría existencial, es fundamental en el marco actual de dominación y control neoliberal. Para ello, el artículo se divide en tres momentos: el primero, expone el actual neoliberalismo temporal como esa figura hegemónica con la cualidad de capturar y cancelar el futuro, y evitar toda alternativa a dicho sistema. El segundo presenta los elementos de la ontología aromática, como una forma de resistencia frente a la aceleración, la hiperindividualización y el rendimiento del Homo digitalis. Finalmente, muestra cómo dicho proyecto da paso a una política a contratiempo, la cual, en la práctica, impacta y rompe la barrera de control que el sistema extiende sobre lo cotidiano con la intención de impedir que el sujeto imagine algún futuro posible fuera de la reproducción neoliberal.
La distopía como espíritu de nuestra época: crisis de la modernidad y del imaginario utópico
Authors: Retamal Christian 
Published: July 2024

Este artículo analiza cómo el imaginario distópico contemporáneo expresa una crisis profunda de los ideales ilustrados de la modernidad. La distopía, en cuanto representación de sociedades opresivas, concentra diversos temores sociales generalizados que cuestionan las promesas de emancipación de la modernidad. En su origen, la modernidad se basaba en concepciones utópicas y en la noción del progreso como motor histórico. Pero sus contradicciones internas erosionaron la imaginación utópica. En su reemplazo surgieron imaginarios distópicos que globalizaron ansiedades sobre el totalitarismo, la crisis ecológica, la pérdida de individualidad, etcétera. La pandemia y la experiencia cotidiana del cambio climático intensificaron la sensación de catástrofe inminente. El artículo examina los problemas sociales y filosóficos implicados en la preeminencia actual de la distopía. Aborda temas como la incertidumbre, la ansiedad existencial, el cuestionamiento de la identidad y el surgimiento de nuevos nihilismos. Analiza la expresión de la distopía en la cultura de masas, sus manifestaciones políticas y su impacto en la visión del futuro. Asimismo, explora problemas filosóficos como la crisis de la noción de progreso, el quiebre de la teleología histórica y la extensión de la melancolía de izquierda. En conjunto, este análisis apunta a elucidar cómo la distopía erosiona los ideales emancipadores del proyecto ilustrado de la modernidad. A pesar de ello, se analiza cómo en la distopía hay un débil utopismo invertido en espera de ser desarrollado.
La vida buena: dossier
Authors: Pino Posada Pablo , Manrique Tisnés Horacio , Altuna Lizaso Belén 
Published: July 2024

A juzgar por los artículos aquí publicados, es posible nombrar para el ámbito de las humanidades por lo menos tres tendencias en la reflexión contemporánea sobre la vida buena. En primer lugar, resulta manifiesta la perspectiva crítica desde la que se aborda el problema propuesto. De un lado, una serie de artículos desmitifican escenarios, prácticas y estados que tradicionalmente se han considerado propicios, cuando no paradigmáticos, para la persecución de la vida plena. De otro lado, varias contribuciones acuden al subgénero crítico de los diagnósticos sociales y leen en los tiempos que corren los síntomas de un buen número de patologías, no por conocidas menos alarmantes. En este caso los autores tematizan la dominación neoliberal, el desencanto de la distopía y el retorno de la barbarie. El desenmascaramiento emprendido por estas contribuciones también se aventura en una estrategia de contragolpe que busca actualizar remedios, maniobras y recursos, entre otros. La tercera tendencia tiene que ver con la actualidad de una teoría particular de la vida buena. Nos referimos de manera específica a la pertinencia de la teoría de la resonancia de Hartmut Rosa. Los autores de tres artículos se sintieron llamados a reflexionar sistemáticamente sobre el aporte de la teoría de la resonancia en el diálogo con otros cuerpos teóricos, como el de la misma Teoría Crítica en sus desarrollos recientes (donde es posible situar a Rosa), el de la justicia epistémica y el de la recepción literaria.
Intracoronary Administration of Epinephrine in the Refractory No-Reflow Phenomenon in Patients With Acute Myocardial Infarction
Authors: Vyshlov E. V. , Dil S. V. , Baev А. Е. , Gergert Е. S. , Pekarsky S. E. , Ryabov V. V. 
Published: July 2024

Aim. To evaluate the efficacy and safety of intracoronary epinephrine for the treatment of refractory no-reflow phenomenon in patients with ST-segment elevation myocardial infarction (STEMI) during percutaneous coronary intervention (PCI).Material and methods. A single-site prospective controlled study “Intracoronary administration of epinephrine for refractory no-reflow phenomenon in patients with acute myocardial infarction” was conducted (registration on ClinicalTrials.gov: NCT04573751). The study included 40 patients with refractory no-reflow phenomenon, which was identified when it was not resolved with at least one of the following means: nitroglycerin, adenosine, papaverine, platelet receptor inhibitors IIB/IIIA, or thromboaspiration. Patients were divided into 2 groups: patients of group 1 (n=18) were injected with intracoronary epinephrine 100 μg, patients of group 2 (n=22) received standard therapy without epinephrine. The groups did not differ in the main baseline clinical and anamnestic characteristics, with the exception of the predominance of men in the control group: 86.4% vs. 55.6% (p=0.03). Results. In the epinephrine group, TIMI 3 blood flow was more often achieved: 55.6% vs. 0% (p<0.01); reduction in ST elevation >50% within 1 hour after PCI: 72.2% vs. 31.8% (p=0.01). Concentrations of troponin I 12-24 h after PCI were significantly lower in the epinephrine group than in the control group: 15.2 (6;25) ng/ml vs. 25 (10;40) ng/ml (p=0.03). No life-threatening hemodynamic disorders or cardiac arrhythmias were recorded after the administration of epinephrine. No statistically significant differences were found in cardiac ultrasound data and MACE (Major Adverse Cardiovascular Events) during 30 days of follow-up.Conclusions. Intracoronary epinephrine 100 μg in STEMI patients with refractory no-reflow phenomenon during PCI is a safe and effective method for improving the blood flow in the infarct-related coronary artery. The prevalence of refractory no-reflow phenomenon among STEMI patients in our study reached 4.6%.
Tenon’s patch grafting: An inexpensive technique for managing corneal perforation and descemetocele - Our experience of 12 months post-operative follow-up
Authors: Mazumdar Shefali , Maurya Rajendra  P , Gangwar Alok , Singh Jatin Kumar , Wahab Adeeba , Gupta Arpit , Gupta Siddhartha 
Published: July 2024

To assess the results of tenon’s patch grafting (TPG) in corneal perforation and descemetocele ranging from 2 to 5.5 mm with a minimum 12 months follow-up. This study was a prospective interventional study in which 35 eyes with corneal perforation (25, 71.4%) and descemetocele (10, 28.5%) of different sizes (2-5.5mm) were surgically treated with tenon's patch grafting (TPG) by a single surgeon at a tertiary centre. Preoperative, operative, and post-operative data were recorded. The eyes were evaluated over a minimum postoperative period of 12 months. The outcome of TPG was assessed based on the achievement and maintenance of the anatomical integrity of the eye. Statistical analysis was conducted using SPSS. The mean size of the corneal lesions for corneal perforation was (3.1±1.04 mm) and for descemetocele was (2.45±0.42 mm). The most common underlying ocular pathology was infectious keratitis in 23(65.7%) patients. The most common systemic comorbidity was diabetes mellitus in 10 (28.5%) patients. At 12 months postoperative follow-up, the integrity of the globe was maintained in 69% eyes. In the entire post-op follow-up eight Keratoplasty procedures, seven cataract surgeries, two repeat TPG procedures and one evisceration were done as additional surgeries. Tenon’s Patch grafting is a simple, inexpensive and an effective surgical modality for achieving globe integrity with minimal post-operative care in corneal perforation/descemetocele of 2-5mm.