bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic factors are not the direct mediators of the association between type 2 diabetes and osteoporosis
Authors: Yang Qifan , Wang Xinyu , Liu Yanwei , Liu Jing , Zhu Dong 
Published: July 2024

ObjectiveThe causal relationship between type 2 diabetes mellitus (T2DM) and osteoporosis (OS) remains unclear. This study aims to investigate the causal relationship and explore the potential metabolic mechanism and its mediating role.MethodsWe conducted a comprehensive study, gathering data on 490,089 T2DM patients from the genome-wide association study (GWAS) database and selecting OS data from FinnGen and MRC-IEU sources, including 212,778 and 463,010 patients, respectively, for causal analysis. Simultaneously, we explored the potential roles of three obesity traits and 30 metabolic and inflammation-related mediating variables in the causal relationship.ResultsThere is a strong causal relationship between T2DM and OS. The data from our two different database sources appeared in the same direction, but after correcting for body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR), the direction became the same. T2DM may increase the risk of OS [odds ratio (OR) &gt; 1.5, p &lt; 0.001]. Steiger’s test results show that there is no reverse causality. No risk factors related to glycolipid metabolism, amino acid metabolism, and inflammation were found to mediate the causal relationship.ConclusionThis study’s findings indicate a robust causal relationship between T2DM and OS, influenced by relevant factors such as BMI. Our results shed light on the pathogenesis of OS and underscore the importance for clinicians to treat metabolic disorders to prevent osteoporosis.
Association between genetically plasma proteins and osteonecrosis: a proteome-wide Mendelian randomization analysis
Authors: Meng Chen , Ren Junxiao , Gu Honglin , Shi Hongxin , Luo Huan , Wang Zhihao , Li Chuan , Xu Yongqing 
Published: July 2024

BackgroundPrevious studies have explored the role of plasma proteins on osteonecrosis. This Mendelian randomization (MR) study further assessed plasma proteins on osteonecrosis whether a causal relationship exists and provides some evidence of causality.MethodsSummary-level data of 4,907 circulating protein levels were extracted from a large-scale protein quantitative trait loci study including 35,559 individuals by the deCODE Genetics Consortium. The outcome data for osteonecrosis were sourced from the FinnGen study, comprising 1,543 cases and 391,037 controls. MR analysis was conducted to estimate the associations between protein and osteonecrosis risk. Additionally, Phenome-wide MR analysis, and candidate drug prediction were employed to identify potential causal circulating proteins and novel drug targets.ResultsWe totally assessed the effect of 1,676 plasma proteins on osteonecrosis risk, of which 71 plasma proteins had a suggestive association with outcome risk (P &lt; 0.05). Notably, Heme-binding protein 1 (HEBP1) was significant positively associated with osteonecrosis risk with convening evidence (OR, 1.40, 95% CI, 1.19 to 1.65, P = 3.96 × 10−5, PFDR = 0.044). This association was further confirmed in other MR analysis methods and did not detect heterogeneity and pleiotropy (all P &gt; 0.05). To comprehensively explore the health effect of HEBP1, the phenome-wide MR analysis found it was associated with 136 phenotypes excluding osteonecrosis (P &lt; 0.05). However, no significant association was observed after the false discovery rate adjustment.ConclusionThis comprehensive MR study identifies 71 plasma proteins associated with osteonecrosis, with HEBP1, ITIH1, SMOC1, and CREG1 showing potential as biomarkers of osteonecrosis. Nonetheless, further studies are needed to validate this candidate plasma protein.
Hypermethylation of the glutathione peroxidase 4 promoter predicts poor prognosis in patients with hepatitis B virus-associated acute-on-chronic liver failure
Authors: Su Xing , Han Li-Yan , Wang Jing , Zhang Ying , Luo Peng-Yu , Gao Shuai , Fan Yu-Chen , Wang Jing-Wei , Wang Kai 
Published: July 2024

BackgroundHepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a syn-drome with a high short-term mortality rate, and its prognosis is critical in clinical management. This study aimed to investigate the clinical significance of glutathione peroxidase 4 (GPX4) in the occurrence and development of HBV-ACLF and its prognostic value for 90-day mortality.MethodsThe expression levels of GPX4, oxidative stress-related molecules and inflammatory cytokines in serum or peripheral blood mononuclear cells (PBMCs) of 289 participants were determined by RT-qPCR or ELISA, and the methylation level of GPX4 promoter in PBMCs was determined by MethyLight.ResultsThe expression levels of GPX4 in the PBMCs and serum of HBV-ACLF patients were lower than those in non-HBV-associated acute-on-chronic liver failure (non-HBV ACLF) patients, patients with chronic hepatitis B (CHB) and healthy control (HC) individuals, while the methylation level of the GPX4 promoter was greater. In HBV-ACLF patients, the methylation level of the GPX4 promoter is correlated with oxidative stress, inflammation-related molecules, and some clinicopathological indicators. The methylation level of the GPX4 promoter was identified as an independent risk factor for 90-day mortality in HBV-ACLF patients and yielded a larger area under the receiver operating characteristic curve (AUROC) than the model for end-stage liver disease (MELD) score in predicting 90-day mortality.ConclusionThe GPX4 promoter methylation level has promising potential as a predictor of 90-day mortality in patients with HBV-ACLF.
Dual chiral structures in the cuticle of Protaetia mirifica analyzed with Mueller matrix spectroscopic ellipsometry
Authors: Mendoza-Galván Arturo , Magnusson Roger , Jansson Nicklas , Arwin Hans , Järrendahl Kenneth 
Published: July 2024

Many species of beetles from the family Scarabaeidae reflect light with near-circular polarization. In some cases, spectral narrow-band polarization phenomena result in a distinct color with a metallic shine. In other cases, broad-band features are seen, and these beetles have a silvery or goldish appearance. These features in the cuticles originate from helicoidal structures, so-called circular Bragg structures and also referred to as Bouligand structures. In this communication, Protaetia mirifica, exhibiting near-circular polarization properties in dual spectral regions, centered approximately at the wavelengths of 474 and 770 nm, is investigated in considerable detail using Mueller matrix spectroscopic ellipsometry (MMSE). From interference oscillations in the MMSE spectra, the pitch profile of the helicoidal structures in the beetle cuticle is extracted and further used in electromagnetic modeling of the cuticle structure, including the determination of epicuticle and exocuticle thicknesses (280 nm and 8.1 μm, respectively) and anisotropic optical properties. These findings are confirmed by scanning electron microscopy. The analysis shows that the uppermost 4 μm of the cuticle has a nearly constant pitch of 310 nm, which abruptly jumps to 440 nm and then gradually increases up to 575 nm. Sum decompositions of MMSE spectra reveal that the beetle cuticle reflects like a circular polarizer or like a dielectric mirror, depending on the spectral region.
The effect of aromatherapy on post-stroke depression: study protocol for a pilot randomized controlled trial
Authors: Li Yujia , Hu Zekai , Zhou Kun , Wang Yanyu , Zhang Xinglin , Xue Han , Hu Jun , Wang Jie 
Published: July 2024

BackgroundPost-stroke depression (PSD) is a prevalent psychiatric disorder affecting about one-third of stroke survivors, significantly hindering recovery and quality of life. PSD also imposes a substantial burden on caregivers and healthcare systems. Aromatherapy has shown promise in alleviating depression, anxiety, and sleep disorders. This pilot randomized controlled trial aims to assess the feasibility and preliminary efficacy of mixed herb aromatherapy in treating PSD. Feasibility outcomes encompass recruitment, intervention adherence, assessment completion and safety assessment. Secondary outcomes include evaluations of depression, anxiety, cognitive function, sleep quality, quality of life, and brain function using EEG and fNIRS.MethodsThis single-blind pilot randomized controlled trial will be conducted at the Second Rehabilitation Hospital of Shanghai, enrolling ninety-nine post-stroke patients with PSD. Participants will be randomized into three groups: a Non-Active Control Group receiving standardized rehabilitation therapy, a CBT Group receiving conventional rehabilitation with bi-weekly CBT sessions, and an Aromatherapy Group receiving conventional rehabilitation with daily aromatic inhalation sessions. Interventions will last for four weeks, with efficacy assessed at baseline, post-intervention, and one month post-intervention. Rating scales will be used to measure changes in depression, sleep quality, cognitive function, and quality of life. EEG and fNIRS will specifically be used to measure changes in cerebral cortex activity and their correlations with depression. Feasibility will be evaluated through recruitment, intervention adherence, assessment completion and safety assessment.DiscussionThis pilot study highlights the potential of mixed herb aromatherapy inhalation for treating PSD, addressing limitations of CBT by promoting self-management. While demonstrating feasibility through recruitment, adherence, assessment completion and safety assessment, the study also acknowledges limitations such as unequal intervention times, the lack of physical function data. And the use of culturally relevant plant powders may enhance compliance but limits generalizability. Despite these constraints, the study provides valuable preliminary data and insights into the mechanisms of aromatherapy, encouraging further research and development of effective PSD treatments.
Mortality trends in people with disabilities before and during the COVID-19 pandemic in South Korea, 2017–2022
Authors: Kim Ye-Soon , Kim Ju-Hee , Kwon Sooyoung , Kim Joo-Hee , Kim Hyun-Ji , Ho Seung Hee 
Published: July 2024

ObjectiveTo investigate temporal trends in mortality rates and underlying causes of death in persons with disabilities before and during the coronavirus disease 2019 (COVID-19) pandemic.MethodsAnnual mortality rates and causes of death were analyzed using data covering the 2017–2022 period.ResultsThe mortality rate among people with disabilities increased from 2017 to 2022; the rate was five times higher during COVID-19 in this population than in the general population. When analyzing the cause of death, the incidence of infectious diseases and tuberculosis decreased after COVID-19. In contrast, the incidence of other bacillary disorders (A30–A49) increased. The incidence of respiratory system diseases (J00–J99), influenza and pneumonia (J09–J18), and other acute lower respiratory infections (J20–J22) decreased before COVID-19, while the incidence of lung diseases due to external agents (J60–J70), other respiratory diseases principally affecting the interstitium (J80–J84), and other diseases of the pleura (J90–J94) increased during the pandemic. The risk of COVID-19 death among people with disabilities was 1.1-fold higher for female patients (95% CI = 1.06–1.142), 1.41-fold for patients aged 70 years and older (95% CI = 1.09–1.82), and 1.24-fold higher for people with severe disabilities (95% CI = 1.19–1.28).ConclusionsThe mortality rate in people with disabilities significantly increased during COVID-19, compared with that before the pandemic. People with disabilities had a higher mortality rate during COVID-19 compared with the general population. Risk factors must be reduced to prevent high mortality rates in this population.
Residential childcare worker perceptions of work-related achievement and pride
Authors: Brend Denise Michelle , Olaniyan Oyeniyi Samuel , Collin-Vézina Delphine 
Published: July 2024

IntroductionMultiple risk and protective factors influence the wellbeing and retention of child protective and youth justice professionals. Less attention has been given to empirically understand how residential childcare workers (RCW) experience these factors. A sense of pride and of achievement may be related to competence and satisfaction, which have been identified as protective factors against staff turnover.MethodsResponses to the Secure Base Interview Protocol question “What aspects of caring for (name of child in their care) have given you the greatest sense of pride or achievement?” were extracted from individual interview transcripts from Canadian RCW and analyzed using the Interpretive Description methodology. Themes were aggregated using the thematic analysis technique to create descriptions of RCW pride and achievement.ResultsThe RCW identified many experiences of work-related pride and achievement while caring for children and youth. These positive experiences were described to occur contingent on the level of mutuality and trust in the helping relationship shared between the RCW and child or youth in their care.DiscussionThe reciprocal nature of the relationships described by RCW that gave rise to their felt sense of pride and accomplishment is a novel finding. Future work is indicated to better understand how protective factors related to RCW wellbeing may indeed be relationally constructed and dependent.
Benchmark of the Oxford Nanopore, EM-seq, and HumanMethylationEPIC BeadChip for the detection of the 5mC sites in cancer and normal samples
Authors: Deinichenko Kseniia A. , Vynogradskaya Valentina G. , Grebnev Pavel A. , Mikova Valeriya M. , Bobylev Dmitriy O. , Shaymardanov Abusaid M. , Ivashechkin Alexey A. , Erokhina Marina V. , Akinshina Alexandra I. , Semyanihina Anna V. , Mitrofanov Sergey I. , Grammatikati Konstantin S. , Yudin Vladimir S. , Yudin Sergey M. , Makhotenko Antonida V. , Keskinov Anton A. , Kraevoy Sergey A. , Makarova Anna S. , Snigir Ekaterina A. , Svetlichnyy Dmitry V. , Skvortsova Veronika I. 
Published: July 2024

Introduction: Whole-genome DNA methylation identification is crucial for profiling physiologically and clinically relevant epigenetic changes. Although there are multiple experimental methods, their accuracy, advantages, and disadvantages need to be investigated in their application to complex tissue objects. In this study, we performed a benchmark of 5mC detection with Oxford Nanopore and enzymatic methyl-sequencing (EM-seq) methods.Material and Methods: To this end, we profiled in a genome-wide manner 5mC sites in colorectal tumors and normal tissues for three patients and applied the HumanMethylationEPIC BeadChip as an additional control approach. We estimated the whole-genome scale of the methylation detection that each method yields.Results: Our investigation describes the sensitivity and specificity of each platform and the impact that sequencing coverage brings. Our analysis revealed the higher sensitivity and specificity of Nanopore sequencing over the EM-seq method. Moreover, Oxford Nanopore Technology (ONT) sequencing, followed by Megalodon methylation detection, demonstrates better quantitative agreement of the epigenetic signals between biological replicates. Furthermore, our analysis highlights that with 40× and above coverage, EM-seq slightly outperforms ONT and yields highly accurate detection of the 5mC signals (AuPR = 0.99178 and AuROC = 0.98161).Conclusion: The study was performed on colon cancer and adjacent normal tissue samples, placing our investigation close to the real application of methylation studies in oncology.
Effects of sensorimotor training on functional and pain outcomes in achilles tendinopathy: a systematic review
Authors: Kim Myoung-Hwee , Martin Wille , Quarmby Andrew , Stoll Josefine , Engel Tilman , Cassel Michael 
Published: July 2024

BackgroundConsidering the neuromuscular alterations in Achilles tendinopathy (AT), sensorimotor training (SMT) might be beneficial to restore the neuromuscular capacity of the muscle-tendon complex and thereby improve patients' functions and alleviate symptoms. However, there is still a lack of knowledge concerning the effects of SMT on improving functional (e.g., strength) and pain outcomes in this population. Thus, the purpose of this study was to synthesize current evidence to analyze the efficacy of SMT in people with AT.MethodsA systematic electronic search was performed in PubMed, Web of Science, and Cochrane Central Register of Controlled Trials from inception to December 2023. Studies applying SMT in people with AT investigating functional or clinical pain outcomes were considered. Protocols had to incorporate balance, stabilization, proprioception, or vibration training. Patients with insertional or mid-portion AT (≥18 years age) diagnosed with clinical or sonographic evaluation were included.ResultsThe search yielded 823 records. A total of three randomized controlled trials were considered eligible for the analysis. Each trial used a different SMT protocol: balance training, balance with stabilization training, or whole-body vibration training (WBVT) with other co-interventions. Most functional and pain parameters improved compared to baseline. The first study reported a decrease in pain and an increase in performance (i.e., countermovement jump height) and endurance (i.e., number of heel-raises) by 12-week use of a balance training in addition to isometric, concentric/eccentric, and eccentric exercises. The second study evaluated the four weeks effect of SMT (balance and stabilization training plus eccentric exercises) in addition to passive physiotherapy (deep frictions, ice, ultrasound), resulting in an increased plantarflexion peak torque and reduced pain levels. The third study investigating WBVT reported at 12 weeks an increase in flexibility and a decrease in tendon pain.DiscussionSMT in addition to other co-interventions (i.e., eccentric, isometric, concentric/eccentric training, physiotherapy) showed improvements in strength, performance, muscle flexibility, and alleviated clinical outcomes of pain. SMT might therefore be useful as part of a multimodal treatment strategy protocol in patients suffering from AT. However, due to the small number of studies included and the diversity of SMT protocols, the current evidence is weak; its additional effectiveness should be evaluated.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=467698, Identifier CRD42023467698.
Novel reconstruction method using long and narrow gastric tube in laparoscopic proximal gastrectomy for cancer: a retrospective case series study
Authors: Ueda Yoshitake , Kawasaki Takahide , Tanabe Sanshi , Suzuki Kosuke , Ninomiya Shigeo , Etoh Tsuyoshi , Inomata Masafumi , Shiraishi Norio 
Published: July 2024

Background and objectivesTo clarify the safety and feasibility of laparoscopic proximal gastrectomy (LPG) with our novel reconstruction methods.MethodsNovel method is a reconstruction with a long and narrow gastric tube with widening of the proximal side created by linear stapler, and esophagogastrostomy is performed by linear stapler. In conventional method, esophagogastrostomy is performed by a circular stapler. Short- and long-term outcomes of a novel method were compared with those of conventional method.ResultsA total of 44 patients whom LPG was performed were enrolled in this retrospective study. No cases of anastomotic leakage and stenosis were observed in both groups. The cases of postoperative reflux esophagitis (Grade B or higher) at 1 year after operation in the Novel group were less than those in the Conventional group (17% vs. 44%).ConclusionLPG with novel reconstruction method can be easily performed, and may be feasible for the treatment of proximal gastric cancer.
Digital Competency Model as a Talent Management Tool
Authors: Тарзимина М.В. , Байкова Э.Р. , Косурина А.В. 
Published: July 2024

В современную эпоху стремительного технологического и научного развития быть конкурентоспособным значит уметь приспосабливаться к изменчивым условиям экономики и рынка, быть готовым совершенствовать имеющиеся и осваивать новые компетенции. Поэтому передовые компании особое место уделяют обучению и развитию персонала своего главного ресурса. На сегодняшний день управление развитием талантов осуществляется с помощью информационных платформ. Авторы статьи провели сравнение HR-платформ и выдвинули идею о создании новой усовершенствованной программы по оцифровке компетенций сотрудников с целью их дальнейшего развития.
In the modern era of rapid technological and science development to be competitive means to be able to adapt to the changing conditions of the economy and market, to be ready to improve and to learn new skills. Therefore, successful companies pay special attention to training and development of personnel their main resource. Today, talent development is managed through information platforms. The authors of the article compared these platforms and put forward the idea of creating a new improved program for digitizing employee competencies for their further development.
Value-based Management: Evolution of the Concept
Authors: Гали А.И. 
Published: July 2024

В статье анализируется концепция стоимостного управления организацией, ее ключевые принципы. Эволюция концепции рассмотрена с точки зрения отношений компании с ее заинтересованными лицами и с позиции структурных характеристик организации. В конечном итоге построена схема, систематизирующая аспекты стоимостного управления.
The article analyzes the concept of value-based management of an organization, its key principles. The evolution of the concept is considered from the point of view of the relationship of the company with its stakeholders and from the position of the structural characteristics of the organization. In the end, a scheme is constructed that systematizes the aspects of value-based management.
Development Trends in the Russian Insurance Market
Authors: Шарифьянова З.Ф. , Альтдинова Г.З. , Нафикова Р.Р. 
Published: July 2024

В данной статье рассмотрено современное состояние российского рынка страхования, основные тенденции его развития, а также приведены ключевые показатели деятельности страховщиков за 2019 год. Сделаны выводы о приостановлении роста страховых премий в I квартале и невысоких показателях страхового рынка за II квартал 2019 года. Выявлены некоторые проблемы в различных сегментах рынка, приведены наиболее эффективные меры для его развития в краткосрочной перспективе.
This article discusses the current state of the Russian insurance market, the main trends in its development, and also provides key indicators of insurers activities for 2019. Conclusions are made about the suspension of growth of insurance premiums in the first quarter and low indicators of the insurance market for the second quarter of 2019. Some problems were identified in various market segments, the most effective measures for its development in the short term are given.
Use of Electronic Digital Technologies in Human Resource Management
Authors: Ризванова М.А. 
Published: July 2024

В данной статье рассмотрены вопросы, связанные с внедрением и использованием электронно-цифровых технологий в системе управления человеческими ресурсами выявлены современные тенденции в области HRM, играющие важную роль при формировании бизнес-стратегии по управлению персоналом. На основе анализа электронно-цифровых HR-инструментов сформированы принципы и условия использования компаниями веб-технологий при организации управленческих решений.
This article addresses issues related to the implementation and use of electronic-digital technologies in the human resources management system revealed modern trends in the field of HRM, which play an important role in the formation of a business strategy for personnel management. Based on the analysis of electronic digital HR-tools, the principles and conditions for the use of web technologies by companies in the organization of management decisions are formed.