bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between circulating estradiol and thyroid autoimmunity in males
Authors: Chailurkit La-or , Aekplakorn Wichai , Ongphiphadhanakul Boonsong 
Published: October 2013

IntroductionAlthough autoimmune thyroid disease is less common in males, it is unclear whether estrogen contributes to the difference in susceptibility among males.ObjectiveTo examine whether circulating estradiol (E2) is related to thyroid autoimmunity in males.Patients and methodsOne-thousand two-hundred and sixty-three males aged 15–94 years were studied. Serum levels of E2, TSH receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), free thyroxine (FT4), and TSH were measured by ELISA.ResultsCirculating E2varied widely in males, ranging 18.4–403.7 pmol/l with a mean value of 136.2±51.7 pmol/l. E2increased with age (r=0.18,P<0.001). No relationship between E2and BMI was found. When comparing the difference in E2according to the test results of TRAb, TPOAb, and TgAb, it was found that E2was significantly higher in subjects with positive TRAb (TRAb positive, E2=170.3±59.8 pmol/l; TRAb negative, E2=134.0±50.6 pmol/l;P<0.001). No difference in E2was demonstrated according to the results of TPOAb or TgAb. Logistic regression analysis showed that E2was a determinant of positive TRAb, independent of age and BMI. There was no relationship between serum E2and TSH or FT4. However, E2was negatively related to TSH (r=−0.45,P<0.01) in subjects whose TSH levels fell below the reference range (0.3–4.2 mIU/l).ConclusionHigher circulating E2is related to thyroid autoimmunity in males as reflected by positive TRAb.
Cerebral Blood Flow and Glucose Metabolism in Appetite-Related Brain Regions in Type 1 Diabetic Patients After Treatment With Insulin Detemir and NPH Insulin
Authors: van Golen Larissa W. , IJzerman Richard G. , Huisman Marc C. , Hensbergen Jolanda F. , Hoogma Roel P. , Drent Madeleine L. , Lammertsma Adriaan A. , Diamant Michaela 
Published: October 2013

OBJECTIVE
To test the hypothesis that insulin detemir, which is associated with less weight gain than other basal insulin formulations, exerts its weight-modulating effects by acting on brain regions involved in appetite regulation, as represented by altered cerebral blood flow (CBF) or cerebral glucose metabolism (CMRglu).

RESEARCH DESIGN AND METHODS
Twenty-eight male type 1 diabetic patients (age 36.9 ± 9.7 years, BMI 24.9 ± 2.7 kg/m2, A1C 7.5 ± 0.6%) successfully completed a randomized crossover study, consisting of two periods of 12-week treatment with either insulin detemir or NPH insulin, both in combination with prandial insulin aspart. After each treatment period, patients underwent positron emission tomography scans to measure regional CBF and CMRglu.

RESULTS
After 12 weeks, A1C, daily insulin doses, fasting insulin, and blood glucose levels were similar between treatments. Insulin detemir resulted in body weight loss, whereas NPH insulin induced weight gain (between-treatment difference 1.3 kg; P = 0.02). After treatment with insulin detemir relative to NPH insulin, CBF was higher in brain regions involved in appetite regulation, whereas no significant difference in CMRglu was observed.

CONCLUSIONS
Treatment with insulin detemir versus NPH insulin resulted in weight loss, paralleled by increased CBF in appetite-related brain regions in the resting state, in men with well-controlled type 1 diabetes. These findings lend support to the hypothesis that a differential effect on the brain may contribute to the consistently observed weight-sparing effect of insulin detemir.
Diabetes and Risk of Hospitalized Fall Injury Among Older Adults
Authors: Yau Rebecca K. , Strotmeyer Elsa S. , Resnick Helaine E. , Sellmeyer Deborah E. , Feingold Kenneth R. , Cauley Jane A. , Vittinghoff Eric , De Rekeneire Nathalie , Harris Tamara B. , Nevitt Michael C. , Cummings Steven R. , Shorr Ronald I. , Schwartz Ann V. 
Published: October 2013

OBJECTIVE
To determine whether older adults with diabetes are at increased risk of an injurious fall requiring hospitalization.

RESEARCH DESIGN AND METHODS
The longitudinal Health, Aging, and Body Composition Study included 3,075 adults aged 70–79 years at baseline. Hospitalizations that included ICD-9-Clinical Modification codes for a fall and an injury were identified. The effect of diabetes with and without insulin use on the rate of first fall-related injury hospitalization was assessed using proportional hazards models.

RESULTS
At baseline, 719 participants had diabetes, and 117 of them were using insulin. Of the 293 participants who were hospitalized for a fall-related injury, 71 had diabetes, and 16 were using insulin. Diabetes was associated with a higher rate of injurious fall requiring hospitalization (hazard ratio [HR] 1.48 [95% CI 1.12–1.95]) in models adjusted for age, race, sex, BMI, and education. In those participants using insulin, compared with participants without diabetes, the HR was 3.00 (1.78–5.07). Additional adjustment for potential intermediaries, such as fainting in the past year, standing balance score, cystatin C level, and number of prescription medications, accounted for some of the increased risk associated with diabetes (1.41 [1.05–1.88]) and insulin-treated diabetes (2.24 [1.24–4.03]). Among participants with diabetes, a history of falling, poor standing balance score, and A1C level ≥8% were risk factors for an injurious fall requiring hospitalization.

CONCLUSIONS
Older adults with diabetes, in particular those using insulin, are at greater risk of an injurious fall requiring hospitalization than those without diabetes. Among those with diabetes, poor glycemic control may increase the risk of an injurious fall.
Decreased Circulatory Response to Hypovolemic Stress in Young Women With Type 1 Diabetes
Authors: Lindenberger Marcus , Lindström Torbjörn , Länne Toste 
Published: October 2013

OBJECTIVE
Diabetes is associated with hemodynamic instability during different situations involving acute circulatory stress in daily life. Young men with type 1 diabetes have been shown to have impaired circulatory response to hypovolemic stress. The effect of type 1 diabetes on cardiovascular response to hypovolemia in young women is unknown, however.

RESEARCH DESIGN AND METHODS
Lower body negative pressure of 30 cm H2O was used to create rapid hypovolemic stress in 15 young women with type 1 diabetes (DW) and 16 healthy women (control subjects [C]). Compensatory mobilization of venous capacitance blood (capacitance response) and net fluid absorption from tissue to blood were measured with a volumetric technique. Overall cardiovascular responses and plasma norepinephrine levels were measured.

RESULTS
Capacitance response was reduced (DW, 0.67 ± 0.05; C, 0.92 ± 0.06) and developed slower in DW (P &lt; 0.01). Capacitance response was further reduced with increasing levels of HbA1c. Fluid absorption was almost halved in DW (P &lt; 0.01). The initial vasoconstrictor response was reduced and developed slower in DW (P &lt; 0.05). Arterial vasoconstriction was further reduced in the presence of microvascular complications (P &lt; 0.05).

CONCLUSIONS
DW present with decreased and slower mobilization of venous capacitance blood and decreased net fluid absorption from tissue to blood during hypovolemic circulatory stress. Collectively, this indicates that DW are prone to hemodynamic instability, especially in the presence of microvascular complications and poor glycemic control.
Iron Status and Survival in Diabetic Patients With Coronary Artery Disease
Authors: Ponikowska Beata , Suchocki Tomasz , Paleczny Bartłomiej , Olesinska Martyna , Powierza Slawomir , Borodulin-Nadzieja Ludmila , Reczuch Krzysztof , von Haehling Stephan , Doehner Wolfram , Anker Stefan D. , Cleland John G.F. , Jankowska Ewa A. 
Published: October 2013

OBJECTIVE
To investigate the impact of iron status on survival in patients with type 2 diabetes and coronary artery disease (CAD).

RESEARCH DESIGN AND METHODS
Serum ferritin, transferrin saturation (Tsat), and soluble transferrin receptor (sTfR) were measured in 287 patients with type 2 diabetes and stable CAD (65 ± 9 years of age, 78% men).

RESULTS
During a mean follow-up of 45 ± 19 months, there were 59 (21%) deaths and 60 (21%) cardiovascular hospitalizations. Both serum ferritin and sTfR strongly predicted 5-year all-cause mortality rates, independently of other variables (including hemoglobin, measures of renal function, inflammation, and neurohormonal activation). There was an exponential relationship between sTfR and mortality (adjusted hazard ratio [HR] per 1 log mg/L: 4.24 [95% CI 1.43–12.58], P = 0.01), whereas the relationship between ferritin and mortality was U-shaped (for the lowest and the highest quintiles vs. the middle quintile [reference group], respectively: adjusted HR 7.18 [95% CI 2.03–25.46], P = 0.002, and adjusted HR 5.12 [1.48–17.73], P = 0.01). Similar patterns were observed for the composite outcome of all-cause mortality or cardiovascular hospitalization, and in these multivariable models, low Tsat was related to unfavorable outcome.

CONCLUSIONS
Both low and high serum ferritin (possibly reflecting depleted and excessive iron stores, respectively) along with high serum sTfR (reflecting reduced metabolically available iron) identify patients with type 2 diabetes and CAD who have a poor prognosis.
Dose-Response Effect of Fruit and Vegetables on Insulin Resistance in People at High Risk of Cardiovascular Disease
Authors: Wallace Ian R. , McEvoy Claire T. , Hunter Steven J. , Hamill Lesley L. , Ennis Cieran N. , Bell Patrick M. , Patterson Chris C. , Woodside Jayne V. , Young Ian S. , McKinley Michelle C. 
Published: October 2013

OBJECTIVE
The purpose of this randomized controlled trial was to investigate the dose-response effect of fruit and vegetable (F&V) intake on insulin resistance (IR) in people who are overweight and at high risk of cardiovascular disease (CVD).

RESEARCH DESIGN AND METHODS
A total of 105 participants (mean age 56 years) followed a 4-week washout diet (one to two portions of F&Vs per day). Ninety-two participants completed the washout and were randomized to receive one to two, four, or seven portions of F&Vs per day for 12 weeks. IR was assessed at the start and end of this 12-week period by the two-step euglycemic-hyperinsulinemic clamp. Compliance was monitored using a combination of 4-day food diaries and plasma biomarkers of F&V intake.

RESULTS
A total of 89 participants completed the study. Participants attained self-reported F&V intakes of 1.8, 3.8, and 7.0 portions per day (P &lt; 0.001) per group. There was a significant linear increase in serum lutein status across the groups, indicating good compliance (P &lt; 0.001), and body weight was maintained (P = 0.77). No significant difference was found between groups in terms of a change in measures of whole-body, peripheral, or hepatic IR or adiponectin multimers.

CONCLUSIONS
Increased consumption of F&Vs, as advocated in public-health advice, has no effect on IR in overweight individuals who are at high risk of CVD when body weight is maintained. Recent evidence from systematic reviews indicates that particular classes or types of F&Vs may have particular antidiabetic properties; hence, it is possible that benefits may only be observed in response to a more specific fruit or vegetable intervention.
Effect of Custom-Made Footwear on Foot Ulcer Recurrence in Diabetes
Authors: Bus Sicco A. , Waaijman Roelof , Arts Mark , de Haart Mirjam , Busch-Westbroek Tessa , van Baal Jeff , Nollet Frans 
Published: October 2013

OBJECTIVE
Custom-made footwear is the treatment of choice to prevent foot ulcer recurrence in diabetes. This footwear primarily aims to offload plantar regions at high ulcer risk. However, ulcer recurrence rates are high. We assessed the effect of offloading-improved custom-made footwear and the role of footwear adherence on plantar foot ulcer recurrence.

RESEARCH DESIGN AND METHODS
We randomly assigned 171 neuropathic diabetic patients with a recently healed plantar foot ulcer to custom-made footwear with improved and subsequently preserved offloading (∼20% peak pressure relief by modifying the footwear) or to usual care (i.e., nonimproved custom-made footwear). Primary outcome was plantar foot ulcer recurrence in 18 months. Secondary outcome was ulcer recurrence in patients with an objectively measured adherence of ≥80% of steps taken.

RESULTS
On the basis of intention-to-treat, 33 of 85 patients (38.8%) with improved footwear and 38 of 86 patients (44.2%) with usual care had a recurrent ulcer (relative risk −11%, odds ratio 0.80 [95% CI 0.44–1.47], P = 0.48). Ulcer-free survival curves were not significantly different between groups (P = 0.40). In the 79 patients (46% of total group) with high adherence, 9 of 35 (25.7%) with improved footwear and 21 of 44 (47.8%) with usual care had a recurrent ulcer (relative risk −46%, odds ratio 0.38 [0.15–0.99], P = 0.045).

CONCLUSIONS
Offloading-improved custom-made footwear does not significantly reduce the incidence of plantar foot ulcer recurrence in diabetes compared with custom-made footwear that does not undergo such improvement, unless it is worn as recommended.
Effectiveness of Early Intensive Therapy on β-Cell Preservation in Type 1 Diabetes
Authors: Buckingham Bruce , Beck Roy W. , Ruedy Katrina J. , Cheng Peiyao , Kollman Craig , Weinzimer Stuart A. , DiMeglio Linda A. , Bremer Andrew A. , Slover Robert , Tamborlane William V. ,   Diabetes Research in Children Network (DirecNet) and Type 1 Diabetes TrialNet Study Groups
Published: October 2013

OBJECTIVE
To assess effectiveness of inpatient hybrid closed-loop control (HCLC) followed by outpatient sensor-augmented pump (SAP) therapy initiated within 7 days of diagnosis of type 1 diabetes on the preservation of β-cell function at 1 year.

RESEARCH DESIGN AND METHODS
Sixty-eight individuals (mean age 13.3 ± 5.7 years; 35% female, 92% Caucasian) were randomized to HCLC followed by SAP therapy (intensive group; N = 48) or to the usual-care group treated with multiple daily injections or insulin pump therapy (N = 20). Primary outcome was C-peptide concentrations during mixed-meal tolerance tests at 12 months.

RESULTS
Intensive-group participants initiated HCLC a median of 6 days after diagnosis for a median duration of 71.3 h, during which median participant mean glucose concentration was 140 mg/dL (interquartile range 134–153 mg/dL). During outpatient SAP, continuous glucose monitor (CGM) use decreased over time, and at 12 months, only 33% of intensive participants averaged sensor use ≥6 days/week. In the usual-care group, insulin pump and CGM use were initiated prior to 12 months by 15 and 5 participants, respectively. Mean HbA1c levels were similar in both groups throughout the study. At 12 months, the geometric mean (95% CI) of C-peptide area under the curve was 0.43 (0.34–0.52) pmol/mL in the intensive group and 0.52 (0.32–0.75) pmol/mL in the usual-care group (P = 0.49). Thirty-seven (79%) intensive and 16 (80%) usual-care participants had a peak C-peptide concentration ≥0.2 pmol/mL (P = 0.30).

CONCLUSIONS
In new-onset type 1 diabetes, HCLC followed by SAP therapy did not provide benefit in preserving β-cell function compared with current standards of care.
Peripartum Management of Glycemia in Women With Type 1 Diabetes
Authors: Achong Naomi , Duncan Emma L. , McIntyre H. David , Callaway Leonie 
Published: October 2013

OBJECTIVE
We aimed to 1) describe the peripartum management of type 1 diabetes at an Australian teaching hospital and 2) discuss factors influencing the apparent transient insulin independence postpartum.

RESEARCH DESIGN AND METHODS
We conducted a retrospective review of women with type 1 diabetes delivering singleton pregnancies from 2005 to 2010. Information was collected regarding demographics, medical history, peripartum management and outcome, and breast-feeding. To detect a difference in time to first postpartum blood glucose level (BGL) &gt;8 mmol/L between women with an early (&lt;4 h) and late (&gt;12 h) requirement for insulin postpartum, with a power of 80% and a type 1 error of 0.05, at least 24 patients were required.

RESULTS
An intravenous insulin infusion was commenced in almost 95% of women. Univariate analysis showed that increased BMI at term, lower creatinine at term, longer duration from last dose of long- or intermediate-acting insulin, and discontinuation of an insulin infusion postpartum were associated with a shorter time to first requirement of insulin postpartum (P = 0.005, 0.026, 0.026, and &lt;0.001, respectively). There was a correlation between higher doses of insulin commenced postpartum and number of out-of-range BGLs (r[36] = 0.358, P = 0.030) and hypoglycemia (r[36] = 0.434, P = 0.007). Almost 60% had at least one BGL &lt;3.5 mmol/L between delivery and discharge.

CONCLUSIONS
Changes in the pharmacodynamic profile of insulin may contribute to the transient insulin independence sometimes observed postpartum in type 1 diabetes. A dose of 50–60% of the prepregnancy insulin requirement resulted in the lowest rate of hypoglycemia and glucose excursions. These results require validation in a larger, prospective study.
Antibiotics Versus Conservative Surgery for Treating Diabetic Foot Osteomyelitis: A Randomized Comparative Trial
Authors: Lázaro-Martínez José Luis , Aragón-Sánchez Javier , García-Morales Esther 
Published: October 2013

OBJECTIVE
No prospective trials have been carried out comparing antibiotic treatment alone with primarily surgical treatment in patients with diabetes and foot osteomyelitis. The aim of the current study was to compare the outcomes of the treatment of diabetic foot osteomyelitis in patients treated exclusively with antibiotics versus patients who underwent conservative surgery, following up the patients for a period of 12 weeks after healing.

RESEARCH DESIGN AND METHODS
Between 1 January 2010 and 31 December 2012, a prospective randomized comparative trial (clinical trial reg. no. NCT01137903, clinicaltrials.gov) of patients with diabetes who had received a diagnosis of neuropathic foot ulcers complicated by osteomyelitis was carried out at the Diabetic Foot Unit at the Complutense University of Madrid. Patients were randomized into the following two groups: the antibiotics group (AG) and the surgical group (SG). Antibiotics were given for a period of 90 days in the AG. Patients in the SG received conservative surgery with postoperative antibiotic treatment for 10 days.

RESULTS
Eighteen patients (75%) achieved primary healing in the AG, and 19 (86.3%) in the SG (P = 0.33). The median time to healing was 7 weeks (quartile [Q] 1 to Q5, Q3–Q8) in the AG and 6 weeks (Q1–Q3, Q3–Q9) in the SG (P = 0.72). The conditions of four patients from the AG worsened (16.6%), and they underwent surgery. Three patients from the SG required reoperation. No difference was found between the two groups regarding minor amputations (P = 0.336).

CONCLUSIONS
Antibiotic therapy and surgical treatment had similar outcomes in terms of healing rates, time to healing, and short-term complications in patients with neuropathic forefoot ulcers complicated by osteomyelitis without ischemia or necrotizing soft tissue infections.
Etiology of Hyperglycemia in Hospitalized Patients Using the A1C Test
Authors: Katsnelson Svetlana , Balliu Erjola , Ozbek Ayse Bag , Schiwek Anna , Lohiya Sheela , Aravind Deepa , Patiag Ronald , Gavi Shai , Charitou Marina M. 
Published: October 2013

IN BRIEF
This article describes a single-center study evaluating hospitalized hyperglycemic patients using the A1C test. Results indicated that A1C measurement may be a useful test for hyperglycemic patients in the inpatient setting.
Palaeontology, taxonomic revision and variability of some species of the genus Gassendiceras Bert et al., 2006 (Ammonitina, Upper Barremian) from southeastern Franc
Authors: Bert Didier , Bersac Stéphane , Delanoy Gérard , Canut Léon 
Published: October 2013

Abstract
Bed-by-bed sampling of twelve Barremian sections in southeastern France from pelagic basin (Vocontian Basin) to neritic platforms (Arc of Castellane, Arc of Nice and Provencal Domain) has enabled the collection of isochronous samples of the ammonite genus Gassendiceras. Three poorly known species of the Toxancyloceras vandenheckei Zone (Upper Barremian) are revised: G. alpinum, G. multicostatum and G. hoheneggeri; two new species are described (G. rebouleti nov. sp. and G. bosellii nov. sp.). The intraspecific variability of particular species was recognised. This variability is between slender peramorphic and robust paedomorphic extreme morphologies, with the presence of all intermediates.
Organic geochemistry of Upper Carboniferous bituminous coals and clastic sediments from the Lublin Coal Basin
Authors: Gola Marek R. , Karger Michał , Gazda Lucjan , Grafka Oliwia 
Published: October 2013

Abstract
Bituminous coals and clastic rocks from the Lublin Formation (Pennsylvanian, Westphalian B) were subjected to detailed biomarker and Rock-Eval analyses. The investigation of aliphatic and aromatic fractions and Rock-Eval Tmax suggests that the Carboniferous deposits attained relatively low levels of thermal maturity, at the end of the microbial processes/initial phase of the oil window. Somewhat higher values of maturity in the clastic sediments were caused by postdiagenetic biodegradation of organic matter. The dominance of the odd carbon-numbered n-alkanes in the range n-C25 to n-C31 , high concentrations of moretanes and a predominance of C 28 and C29 steranes are indicative of a terrigenous origin of the organic matter in the study material. This is supported by the presence of eudesmane, bisabolane, dihydro-ar-curcumene and cadalene, found mainly in the coal samples. In addition, tri- and tetracyclic diterpanes, e. g. 16β(H)-kaurane, 16β(H)-phyllocladane, 16α(H)-kaurane and norisopimarane, were identified, suggesting an admixture of conifer ancestors among the deposited higher plants. Parameters Pr/n-C17 and Rdit in the coal samples show deposition of organic matter from peat swamp environments, with the water levels varying from high (water-logged swamp) to very low (ephemeral swamp). Clastic deposits were accumulated in a flood plain environment with local small ponds/lakes. In pond/lake sediments, apart from the dominant terrigenous organic matter, research also revealed a certain quantity of algal matter, indicated, i.a., by the presence of tricyclic triterpanes C28 and C29 and elevated concentrations of steranes. The Paq parameter can prove to be a useful tool in the identification of organic matter, but the processes of organic matter biodegradation observed in clastic rocks most likely influence the value of the parameter, at the same time lowering the interpretation potential of these compounds. The value of Pr/Ph varies from 0.93 to 5.24 and from 3.49 to 22.57 in the clastic sediments and coals respectively. The microbial degradation of organic matter in both type of rocks and during early stages of diagenesis is confirmed by a high concentration of hopanes, the presence of drimane homologues, bicyclic alkanes and benzohopanes. Moreover, bacteria could also have been connected with the primary input of organic matter, which is shown by the presence of e.g. C30 neohop-13(18)-ene.