bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musical agency reduces perceived exertion during strenuous physical performance
Authors: Fritz Thomas Hans , Hardikar Samyogita , Demoucron Matthias , Niessen Margot , Demey Michiel , Giot Olivier , Li Yongming , Haynes John-Dylan , Villringer Arno , Leman Marc 
Published: October 2013

Significance
Here we present a data set demonstrating that musical agency greatly decreases the perceived exertion during strenuous activity. We believe these findings are a major contribution to how we consider the role of music in the emergence of human societies. Furthermore, these findings are timely because they crucially help to understand the therapeutic power of music, a scientific field about to unfold. Although one would expect this workout with musical feedback (jymmin') to be a rather unconventional and dimensionally constrained (each instrument one-dimensionally regulates a musical signal) way to experience musical agency, the experience of the performers suggests an intimate entwinement of ecstatic pleasure and exertion during the performance.
ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair
Authors: Mourgues Sophie , Gautier Violette , Lagarou Anna , Bordier Christine , Mourcet Amandine , Slingerland Joris , Kaddoum Lara , Coin Frédéric , Vermeulen Wim , Gonzales de Peredo Anne , Monsarrat Bernard , Mari Pierre-Olivier , Giglia-Mari Giuseppina 
Published: October 2013

Significance
A variety of genotoxic agents cause DNA lesions which, when located on a transcribed gene, will block the RNA polymerase II and recruit DNA repair proteins, including the basal transcription factor IIH, to restore the genetic information via the pathway known as transcription-coupled repair. Once the repair process is completed, transcription is expected to restart to restore proper cellular functions. RNA polymerase II restart after DNA repair in higher eukaryotes has not been studied mechanistically. We have identified eleven-nineteen lysine-rich leukemia as specifically involved in transcription resumption after DNA repair and have been able to measure the effect of its absence on transcription and the dynamic behavior of RNA polymerase II during transcription-coupled repair.
Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation
Authors: Matsumoto Shunsuke , Shimada Atsushi , Nyirenda James , Igura Mayumi , Kawano Yoshiaki , Kohda Daisuke 
Published: October 2013

Significance
Asparagine-linked glycosylation is one of the most ubiquitous posttranslational protein modifications in all kingdoms of life. A membrane enzyme, oligosaccharyltransferase (OST), catalyzes the transfer of sugar chains onto the asparagine residues of the Asn-X-Ser/Thr sequon in acceptor proteins. We determined the structures of an archaeal OST in two crystal forms. The comparison with the previous eubacterial OST structure revealed the structural conservation of the catalytic core and the membrane-spanning region. The archaeal and eubacterial OST structures probably correspond to different steps in the OST reaction cycle. The conversion between the structured and unstructured states of a characteristic loop in the membrane-spanning region is the structural basis for the dynamic recognition of the Asn residue in the sequon.
Reduced choice-related activity and correlated noise accompany perceptual deficits following unilateral vestibular lesion
Authors: Liu Sheng , Dickman J. David , Newlands Shawn D. , DeAngelis Gregory C. , Angelaki Dora E. 
Published: October 2013

Significance
Correlations between single-neuron activity and perceptual decisions are used to probe functional links between sensory neurons and perception, but the roles of correlated noise and decoding strategy in shaping these correlations remain unclear. The peripheral vestibular system provides an ideal model system to explore these questions, due to interactions between afferent signals from the two sides of the brain. We made a unilateral lesion to the vestibular labyrinth and recorded from neurons in the contralateral vestibular and cerebellar nuclei. The lesion led to reduced neural sensitivity, reduced correlations with perceptual decisions, and less correlated noise among neurons. Simulations show that these changes could account for the effects of the lesion on behavior.
Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation
Authors: Wood Jeremy P. , Bunce Matthew W. , Maroney Susan A. , Tracy Paula B. , Camire Rodney M. , Mast Alan E. 
Published: October 2013

Significance
The generation of thrombin by prothrombinase, a complex composed of activated (a) factors X (FXa) and V (FVa), is a final step in blood coagulation. We demonstrate that tissue factor pathway inhibitor (TFPI) blocks thrombin generation by prothrombinase at physiologically relevant rates and concentrations, but only during the initiation of clot formation. TFPI mediates this inhibitory activity through two high-affinity interactions, one with FXa and one with FVa. This is the first description of an endogenous human protein that inhibits prothrombinase under physiological conditions and may prevent a full thrombotic response to subthreshold coagulant stimuli that otherwise could occlude blood vessels. It provides unique understanding of thrombotic disorders and has important implications for development of anti-TFPI agents to treat hemophilia.
Differentiated kidney epithelial cells repair injured proximal tubule
Authors: Kusaba Tetsuro , Lalli Matthew , Kramann Rafael , Kobayashi Akio , Humphreys Benjamin D. 
Published: October 2013

Significance
When epithelial cells in the proximal portion of the nephron are damaged they rapidly proliferate to repair the damage to the kidney. Whether a stem cell is responsible for this proliferative response or not is controversial. Although a scattered population of cells can be found in the human proximal tubule that seem to have stem-cell characteristics, they could also represent isolated damaged cells that have dedifferentiated and lost their epithelial characteristics. We resolve these conflicting models using genetic lineage analysis to demonstrate that fully differentiated proximal tubule cells not only proliferate after injury, but they also upregulate apparent stem-cell markers. This study shows that epithelial dedifferentiation is responsible for repair of mouse proximal tubule, rather than an adult stem-cell population.
Hemoglobin-derived porphyrins preserved in a Middle Eocene blood-engorged mosquito
Authors: Greenwalt Dale E. , Goreva Yulia S. , Siljeström Sandra M. , Rose Tim , Harbach Ralph E. 
Published: October 2013

SignificanceFossils, in addition to documenting the existence of extinct species, can often provide information on the behavior of ancient organisms. The present study describes the fossil of a blood-engorged mosquito in oil shale from northwestern Montana. The existence of this rare specimen extends the existence of blood-feeding behavior in this family of insects 46 million years into the past. Heme, the oxygen-carrying group of hemoglobin in the host’s blood, was identified in the abdomen of the fossil mosquito by nondestructive mass-spectrometry analysis. Although large and fragile molecules such as DNA cannot survive fossilization, other complex organic molecules, in this case iron-stabilized heme, can survive intact and provide information relative to the mechanisms of the fossilization process.
Cytosolic reducing power preserves glutamate in retina
Authors: Du Jianhai , Cleghorn Whitney , Contreras Laura , Linton Jonathan D. , Chan Guy C.-K. , Chertov Andrei O. , Saheki Takeyori , Govindaraju Viren , Sadilek Martin , Satrústegui Jorgina , Hurley James B. 
Published: October 2013

Significance
This report shows that the reducing power in the environment influences oxidation of glutamate in a neuronal tissue. Glutamate is a neurotransmitter, and it is especially important as a metabolite because it is required for synthesis of glutathione, other amino acids, and proteins. Glutamate also is a key intermediate in glutamine-dependent anaplerosis, now considered to be a principal source of citric acid cycle intermediates in cancer cells. Our analyses also show that the reducing power in the environmental can influence glutamate oxidation in cancer cells.
Nitric oxide mediates local activity-dependent excitatory synapse development
Authors: Nikonenko Irina , Nikonenko Alexander , Mendez Pablo , Michurina Tatyana V. , Enikolopov Grigori , Muller Dominique 
Published: October 2013

Significance
The development of brain networks is regulated through plasticity and activity-dependent mechanisms that control the continuous formation and pruning of spine synapses. However, the molecular events that contribute to these aspects of structural plasticity remain unclear. By assessing synapse development and spine dynamics in the rodent hippocampus, we find that activity-dependent spine formation is mediated by a postsynaptic signaling cascade implicating NO, cGMP, and vasodilator-stimulated phosphoprotein phosphorylation. Loss of this NO signaling mechanism interferes with the development of excitatory synapses and prevents structural adaptation of hippocampal excitatory synapses to environmental enrichment. These results provide a new understanding of the role played by NO in cognitive deficits and diseases, such as schizophrenia.
Observation of orientation-dependent electron transfer in molecule–surface collisions
Authors: Bartels Nils , Golibrzuch Kai , Bartels Christof , Chen Li , Auerbach Daniel J. , Wodtke Alec M. , Schäfer Tim 
Published: October 2013

Significance
How molecules point in space—that is, their spatial orientation—determines how they interact with their environment. Exchange of energy, photons, and particles as well as chemical reactions are all elementary processes that depend on orientation. Electron transfer reactions are of particular interest because of their importance in a remarkably wide range of phenomena. In this work, we examine electron transfer reactions at surfaces, which control the change of oxidation state in surface chemistry, a critical factor explaining catalytic activity and selectivity. We report a strong orientation dependence for vibrational relaxation of a diatomic molecule colliding with a metal surface, an energy transfer process driven by electron transfer. These observations represent a challenge to modern theories of surface chemistry.
Crystal structure of
Bacillus subtilis
GabR, an autorepressor and transcriptional activator of
gabT
Authors: Edayathumangalam Raji , Wu Rui , Garcia Roman , Wang Yuguang , Wang Wei , Kreinbring Cheryl A. , Bach Alicia , Liao Jingling , Stone Todd A. , Terwilliger Thomas C. , Hoang Quyen Q. , Belitsky Boris R. , Petsko Gregory A. , Ringe Dagmar , Liu Dali 
Published: October 2013

Significance
GabR is a member of the MocR/GabR subfamily of the GntR family of bacterial transcription regulators. It regulates the metabolism of γ-aminobutyric acid, an important nitrogen and carbon source in many bacteria. The crystal structures reported here show that this protein has evolved from the fusion of a type I aminotransferase and a winged helix-turn-helix DNA-binding protein to form a chimeric protein that adopts a dimeric head-to-tail configuration. The pyridoxal 5′-phosphate–binding regulatory domain of GabR is therefore an example of a coenzyme playing a role in transcription regulation rather than in enzymatic catalysis. Our structural and biochemical studies lay the mechanistic foundation for understanding the regulatory functions of the MocR/GabR subfamily of transcription regulators.
Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction
Authors: Unsöld Bernhard , Kaul Axel , Sbroggiò Mauro , Schubert Carola , Regitz-Zagrosek Vera , Brancaccio Mara , Damilano Federico , Hirsch Emilio , Van Bilsen Marc , Munts Chantal , Sipido Karin , Bito Virginie , Detre Elke , Wagner Nana Maria , Schäfer Katrin , Seidler Tim , Vogt Johannes , Neef Stefan , Bleckmann Annalen , Maier Lars S. , Balligand Jean Luc , Bouzin Caroline , Ventura-Clapier Renée , Garnier Anne , Eschenhagen Thomas , El-Armouche Ali , Knöll Ralph , Tarone Guido , Hasenfuß Gerd 
Published: October 2013

Abstract

Aims
Melusin is a muscle-specific chaperone protein whose expression is required for a compensatory hypertrophy response to pressure overload. Here, we evaluated the consequences of melusin overexpression in the setting of myocardial infarction (MI) using a comprehensive multicentre approach.

Methods and results
Mice overexpressing melusin in the heart (TG) and wild-type controls (WT) were subjected to permanent LAD ligation and both the acute response (Day 3) and subsequent remodelling (2 weeks) were examined. Mortality in wild-type mice was significant between Days 3 and 7, primarily due to cardiac rupture, but melusin's overexpression strongly reduced mortality (43.2% in wild-type vs. 27.3% in melusin-TG, P = 0.005). At Day 3 after MI, a time point preceding the mortality peak, TG hearts had increased heat shock protein 70 expression, increased ERK1/2 signalling, reduced cardiomyocyte hyper-contractility and inflammatory cell infiltrates, and increased matricellular protein expression in the infarcted area.
At 2 weeks after MI, melusin overexpression conferred a favourable adaptive remodelling characterized by reduced left ventricle dilatation and better preserved contractility in the presence of a comparable degree of hypertrophy. Adaptive remodelling in melusin TG mice was characterized by reduced apoptosis and fibrosis as well as increased cardiomyocyte contractility.

Conclusions
Consistent with its function as a chaperone protein, melusin overexpression exerts a dual protective action following MI reducing an array of maladaptive processes. In the early phase after MI, reduced inflammation and myocyte remodelling protect against cardiac rupture. Chronically, reduced myocyte loss and matrix remodelling, with preserved myocyte contractility, confer adaptive LV remodelling.
Selecting relative abundance proxies for BMSY and BMEY
Authors: Punt André E. , Smith Anthony D. M. , Smith David C. , Tuck Geoffrey N. , Klaer Neil L. 
Published: October 2013

AbstractThe objectives for many commercial fisheries include maximizing either yield or profit. Clearly specified management targets are a key element of effective fisheries management. Biomass targets are often specified for major commercial fisheries that are managed using quantitative stock assessments where biomass is calculated and tracked over time. BMSY, the biomass corresponding to Maximum Sustainable Yield, is often used as a target when maximizing yield is important, while BMEY is the biomass target to maximize profit. There are difficulties in estimating both quantities accurately, and this paper explores default proxies for each target biomass, expressed as biomass levels relative to carrying capacity, which are more easily estimated. Integration across a range of uncertainties about stock dynamics and the costs of fishing suggests that a proxy for BMSY in the range of 35–40% of carrying capacity minimizes the potential loss in yield compared with that which would arise if BMSY was known exactly, while a proxy for BMEY of 50–60% of carrying capacity minimizes the corresponding potential loss in profit. These estimates can be refined given stock-specific information regarding productivity (particularly the parameter which defines the resilience of recruitment to changes in spawning stock size) and costs and prices. It is more difficult to find a biomass level that achieves a high expected profit than a biomass level that achieves a high expected catch, because the former is sensitive to uncertainties related to costs and prices, as well as parameters which determine productivity.
Motivational interviewing and recovery: experiences of hope, meaning, and empowerment
Authors: Glassman Scott , Kottsieper Petra , Zuckoff Allan , A. Gosch Elizabeth 
Published: October 2013

Purpose
– Non-participation in outpatient dual diagnosis services presents a challenge for providers assisting clients in their recovery. To better understand factors that facilitate participation, the purpose of this paper is to examine positive recovery states – hope, meaning, and empowerment – as they relate to motivational interviewing (MI) and service use.

Design/methodology/approach
– Six dually diagnosed adults completed four baseline assessments, four MI sessions, a post-MI tape-assisted recall interview, and one-month follow-up measures. Simulation modeling analysis of phone survey responses, comparisons of baseline and intervention phase data, and grounded theory analysis of interviews were conducted to determine MI's relationship to the dependent variables.

Findings
– MI was associated with modest improvement in levels of participation, hope, empowerment, and with greater change in life purpose. Key recovery themes were: positive sense of self, increased self-efficacy, and improved relationships. Feelings of safety and trust were tied to greater self-disclosure while more active emotions were more closely linked to the discussion of recovery progress.

Research limitations/implications
– The paper's finding are limited by small sample size and phone survey response sets.

Practical implications
– To better help dually diagnosed clients sustain treatment involvement, MI practitioners should pay special attention to recovery accomplishments, values, abilities, and self-esteem, while linking these attributes to service participation where appropriate and creating a safe, valuing atmosphere conducive to self-disclosure.

Originality/value
– This is the first paper to measure key recovery constructs within MI process, and to explore the role of positive emotions related to MI, recovery, and service participation.
Understanding communication channel choices in team knowledge sharing
Authors: Snyder Jason , Eng Lee-Partridge Joo 
Published: October 2013

Purpose– The goal of this paper is to develop and test a model that explains information and communication channel (ICC) choice for knowledge sharing in work teams.Design/methodology/approach– This paper reviews relevant literature in information and knowledge sharing and communication channel choices to develop the four-layered model. From the four-layered model, an online questionnaire was developed to look at the ICCs that participants have available to them, the ICCs they actually use when sharing information in teams, and their motivations for making their ICC choices.Findings– Although participants reported having access to a wide variety of ICCs, they tended to rely on face-to-face interactions, telephone and e-mail for sharing knowledge. In accordance with the four-layer model, participants reported that ICC choice was impacted by the type of knowledge being shared. In addition, ease of use, reliability, convenience, and the ability of the channel to document communications were all factors motivating ICC selection.Research limitations/implications– The layered model provides a framework for further research to investigate the factors at the outer layers of the four-layered model and the interaction among the layers in affecting ICC choices.Practical implications– The paper attempts to build a model that organizations can use as a guide to implementing strategies for information and knowledge sharing in teams.Originality/value– This paper develops and partially tests a model to understand communication choices and information sharing. It provides a framework to examine “traditional” communication choices in the midst of the uproar of the availability of Web 2.0 technologies.
Media coverage about organisations in critical situations
Authors: Korn Christine , Einwiller Sabine 
Published: October 2013

Purpose– This research aims to investigate how critical media coverage of an organisation affects its employees. The authors expect the effects to be similar to the way media coverage about an individual would affect this person, termed “reciprocal effects”.Design/methodology/approach– Drawing on a framework for the analysis of reciprocal effects of mass media by Kepplinger and qualitative interviews among employees of 14 different organisations undergoing a crisis, the authors develop an employee-model of reciprocal effects for the context of organisational crises.Findings– This qualitative research shows that employees are affected by media coverage on a critical issue about their employer. Mass media are an important source of information for employees in critical situations. The data indicate interpersonal conversations with colleagues are also important for obtaining information and coping with the situation. Employees show emotional reactions, such as helplessness or shame, and a tendency to defend their employer. The better employees feel informed by their organisation's internal communication, the better they know how to cope with the situation. The data indicate that the effects vary with the employees' level of organisational identification.Practical implications– The findings imply that open and constant internal communication with employees during a crisis fosters reactions that stabilise the organisation in critical situations.Originality/value– The study presented here is the first systematic analysis of the impact of media coverage of an organisation on its employees.
Factors associated with the publication of a CEO letter
Authors: Andreia Costa Graciete , Cristina Oliveira Lídia , Lima Rodrigues Lúcia , Craig Russell 
Published: October 2013

Purpose– In most European code-law oriented Latin countries, the publication of a CEO's letter to shareholders in a company's annual report is a fairly recent phenomenon. In this paper, the authors seek to determine the characteristics that explain why companies in one such country, i.e. Portugal, published a CEO letter.Design/methodology/approach– The paper's holistic theoretical framework draws on elements of agency theory, institutional theory and signalling theory. To understand the characteristics of Portuguese holding companies that published CEO letters, the authors used a logistic regression model to explore 266 observations over the years 2006-2011.Findings– The publication of a CEO letter becomes more likely if a firm is audited by a Big 4 accounting firm; has a higher level of profitability; and has a high number of foreign subsidiaries. Other findings are that finance companies are slightly more likely to publish a CEO letter than non-finance companies. The number of CEO letters increased to a peak in 2008, and then declined.Practical implications– The increasing number of companies now publishing a CEO letter raises the concern for regulatory authorities of whether the content of the CEO letter should be audited, since any numbers presented in the management report have to be audited in Portugal.Originality/value– To the best of the authors' knowledge this is the first empirical exploration of the characteristics that explain why companies publish a CEO letter. Mimetic and normative isomorphism is revealed to be a potentially important influence, since there is a tendency of companies audited by Big 4 accounting companies, and with foreign subsidiaries, to publish a CEO letter.