bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Limit: Fuzzy Logic Based Anti-Collision Algorithm for Industrial Internet of Things Applications
Authors: Zhong Dongbo , Cui Zhiyong , Xie Yufei 
Published: June 2024

Passive RFID has the advantages of rapid identification of multi-target objects and low implementation cost. It is the most critical technology in the Industrial Internet of Things information-gathering layer and is extensively applied in various industries, such as smart production, asset management, and monitoring. The signal collision caused by the communication between the reader/writer and tags sharing the same wireless channel has caused a series of problems, such as the reduction of the identification efficiency of the reader/writer and the increment of the missed reading rate, thus restricting the further development of RFID. At present, many hybrid anti-collision algorithms integrate the advantages of Aloha and TS algorithms to optimize RFID system performance, but these solutions also suffer from performance bottlenecks. In order to break through such performance bottleneck, based on the ISE-BS algorithm, we combined the sub-frame observation mechanism and the Q value adjustment strategy and proposed two hybrid anti-collision algorithms. The experimental results show that the two algorithms proposed in this paper have obvious advantages in system throughput, time efficiency and other metrics, surpassing existing UHF RFID anti-collision algorithms.
Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets
Authors: Chen Monica F. , Yang Soo-Ryum , Tao Jessica J. , Desilets Antoine , Diamond Eli L. , Wilhelm Clare , Rosen Ezra , Gong Yixiao , Mullaney Kerry , Torrisi Jean , Young Robert J. , Somwar Romel , Yu Helena A. , Kris Mark G. , Riely Gregory J. , Arcila Maria E. , Ladanyi Marc , Donoghue Mark T.A. , Rosen Neal , Yaeger Rona , Drilon Alexander , Murciano-Goroff Yonina R. , Offin Michael 
Published: June 2024

Abstract

Purpose:
Even though BRAF fusions are increasingly detected in standard multigene next-generation sequencing panels, few reports have explored their structure and impact on clinical course.

Experimental Design:
We collected data from patients with BRAF fusion–positive cancers identified through a genotyping protocol of 97,024 samples. Fusions were characterized and reviewed for oncogenic potential (in-frame status, non-BRAF partner gene, and intact BRAF kinase domain).

Results:
We found 241 BRAF fusion–positive tumors from 212 patients with 82 unique 5′ fusion partners spanning 52 histologies. Thirty-nine fusion partners were not previously reported, and 61 were identified once. BRAF fusion incidence was enriched in pilocytic astrocytomas, gangliogliomas, low-grade neuroepithelial tumors, and acinar cell carcinoma of the pancreas. Twenty-four patients spanning multiple histologies were treated with MAPK-directed therapies, of which 20 were evaluable for RECIST. Best response was partial response (N = 2), stable disease (N = 11), and progressive disease (N = 7). The median time on therapy was 1 month with MEK plus BRAF inhibitors [(N = 11), range 0–18 months] and 8 months for MEK inhibitors [(N = 14), range 1–26 months]. Nine patients remained on treatment for longer than 6 months [pilocytic astrocytomas (N = 6), Erdheim–Chester disease (N = 1), extraventricular neurocytoma (N = 1), and melanoma (N = 1)]. Fifteen patients had acquired BRAF fusions.

Conclusions:
BRAF fusions are found across histologies and represent an emerging actionable target. BRAF fusions have a diverse set of fusion partners. Durable responses to MAPK therapies were seen, particularly in pilocytic astrocytomas. Acquired BRAF fusions were identified after targeted therapy, underscoring the importance of postprogression biopsies to optimize treatment at relapse in these patients.
Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition
Authors: Schmiester Leonard , Brasó-Maristany Fara , González-Farré Blanca , Pascual Tomás , Gavilá Joaquín , Tekpli Xavier , Geisler Jürgen , Kristensen Vessela N. , Frigessi Arnoldo , Prat Aleix , Köhn-Luque Alvaro 
Published: June 2024

Abstract

Purpose:
Development of a computational biomarker to predict, prior to treatment, the response to CDK4/6 inhibition (CDK4/6i) in combination with endocrine therapy in patients with breast cancer.

Experimental Design:
A mechanistic mathematical model that accounts for protein signaling and drug mechanisms of action was developed and trained on extensive, publicly available data from breast cancer cell lines. The model was built to provide a patient-specific response score based on the expression of six genes (CCND1, CCNE1, ESR1, RB1, MYC, and CDKN1A). The model was validated in five independent cohorts of 148 patients in total with early-stage or advanced breast cancer treated with endocrine therapy and CDK4/6i. Response was measured either by evaluating Ki67 levels and PAM50 risk of relapse (ROR) after neoadjuvant treatment or by evaluating progression-free survival (PFS).

Results:
The model showed significant association with patient’s outcomes in all five cohorts. The model predicted high Ki67 [area under the curve; AUC (95% confidence interval, CI) of 0.80 (0.64–0.92), 0.81 (0.60–1.00) and 0.80 (0.65–0.93)] and high PAM50 ROR [AUC of 0.78 (0.64–0.89)]. This observation was not obtained in patients treated with chemotherapy. In the other cohorts, patient stratification based on the model prediction was significantly associated with PFS [hazard ratio (HR) = 2.92 (95% CI, 1.08–7.86), P = 0.034 and HR = 2.16 (1.02 4.55), P = 0.043].

Conclusions:
A mathematical modeling approach accurately predicts patient outcome following CDK4/6i plus endocrine therapy that marks a step toward more personalized treatments in patients with Luminal B breast cancer.
A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2
-Altered Advanced Solid Tumor Malignancies (NCI 10170)
Authors: Maldonado Edward , Rathmell W. Kimryn , Shapiro Geoffrey I. , Takebe Naoko , Rodon Jordi , Mahalingam Devalingam , Trikalinos Nikolaos A. , Kalebasty Arash R. , Parikh Mamta , Boerner Scott A. , Balido Celene , Krings Gregor , Burns Timothy F. , Bergsland Emily K. , Munster Pamela N. , Ashworth Alan , LoRusso Patricia , Aggarwal Rahul R. 
Published: June 2024

Abstract

We sought to evaluate the efficacy of WEE1 inhibitor adavosertib in patients with solid tumor malignancies (cohort A) and clear cell renal cell carcinoma (ccRCC; cohort B). NCT03284385 was a parallel cohort, Simon two-stage, phase II study of adavosertib (300 mg QDAY by mouth on days 1–5 and 8–12 of each 21-day cycle) in patients with solid tumor malignancies harboring a pathogenic SETD2 mutation. The primary endpoint was the objective response rate. Correlative assays evaluated the loss of H3K36me3 by IHC, a downstream consequence of SETD2 loss, in archival tumor tissue. Eighteen patients were enrolled (9/cohort). The median age was 60 years (range 45–74). The median duration of treatment was 1.28 months (range 0–24+). No objective responses were observed in either cohort; accrual was halted following stage 1. Minor tumor regressions were observed in 4/18 (22%) evaluable patients. Stable disease (SD) was the best overall response in 10/18 (56%) patients, including three patients with SD &gt; 4 months. One patient with ccRCC remains on treatment for &gt;24 months. The most common adverse events of any grade were nausea (59%), anemia (41%), diarrhea (41%), and neutropenia (41%). Nine patients (50%) experienced a Grade ≥3 adverse event. Of eight evaluable archival tissue samples, six (75%) had a loss of H3K36me3 by IHC. Adavosertib failed to exhibit objective responses in SETD2-altered ccRCC and other solid tumor malignancies although prolonged SD was observed in a subset of patients. Combination approaches may yield greater depth of tumor response.

Significance:
WEE1 inhibition with adavosertib monotherapy demonstrated limited clinical activity in patients with SETD2-altered solid tumors despite compelling preclinical data indicating a synthetic lethal effect, which did not translate into robust tumor regression. Loss of the H3K36me3 trimethylation mark caused by SETD2-deficiency was confirmed in the majority of evaluable tumors. A subset of patients derived clinical benefit as manifested by minor tumor regressions and prolonged SD.
As três grandes refutações: a crítica pessoana de Eduardo Lourenço pelo prisma da ironia
Authors: Gagliardi Caio 
Published: June 2024

The purpose of this study is to outline the image of Eduardo Lourenço as a critic of Fernando Pessoa, taking into account the totality of Lourenço's texts about the writer, collected in the two volumes of the Complete Works. As a working hypothesis, we analyze the three major refutations of Lourenço's Pessoan criticism: the psychobiography of João Gaspar Simões; José Augusto Seabra's Barthesian thesis related to Caeiro; and the genesic exaltation of Walt Whitman. Along this path, we seek, concomitantly, to highlight, in all these refutations, the recurrence of Pessoa's irony as a fundamental analytical assumption.
The Influence of Immersion on Situational Awareness in a Virtual Environment
Authors: Hébert-Lavoie Maxence , Ozell Benoît , Doyon-Poulin Philippe 
Published: June 2024

Abstract
Researchers have pointed out the need to find an alternative to subjective questionnaires to measure presence in a virtual environment. Situational awareness has been proposed to objectively measure the concept of presence. However, the link between situational awareness and specific factors of presence has not been established. To study this relationship, 60 participants executed a driving task in a virtual environment under different visual conditions while we measured their situational awareness with the situational awareness global assessment technique (SAGAT), and their presence with the presence questionnaire (PQ). During the driving task, we objectively and meaningfully manipulated immersion, a factor of presence, by varying our participants' contrast sensitivity, size of the field of view, and visual acuity. The meaningful manipulation of presence also allowed us to evaluate the functional thresholds of the three aforementioned visual qualities for a driving task, which were previously measured from a multidirectional selection test. Our results indicated a significant positive correlation between SAGAT and PQ. They also showed that SAGAT was sensitive to an immersion's degradation and brought a good diagnosticity on the effect of an immersion's manipulation. Consequently, we conclude that it could represent an objective alternative to subjective questionnaires to measure presence in a virtual environment. Moreover, our assessment of the functional thresholds allowed us to confirm that they were context dependent. Our results indicated that only the contrast sensitivity functional threshold was valid in both a multidirectional selection test and a driving task.
The Attribution of February Extremes over North America: A Forecast-Based Storyline Study
Authors: Lee Donghyun , Sparrow Sarah , Leach Nicholas , Osprey Scott , Lee Jinah , Allen Myles 
Published: June 2024

Abstract
The importance of extreme event attribution rises as climate change causes severe damage to populations resulting from unprecedented events. In February 2019, a planetary wave shifted along the U.S.–Canadian border, simultaneously leading to troughing with anomalous cold events and ridging over Alaska and northern Canada with abnormal warm events. Also, a dry-stabilized anticyclonic circulation over low latitudes induced warm extreme events over Mexico and Florida. Most attribution studies compare the climate model simulations under natural or actual forcing conditions and assess probabilistically from a climatological point of view. However, in this study, we use multiple ensembles from an operational forecast model, promising statistical as well as dynamically constrained attribution assessment, often referred to as the storyline approach to extreme event attribution. In the globally averaged results, increasing CO2 concentrations lead to distinct warming signals at the surface, resulting mainly from diabatic heating. Our study finds that CO2-induced warming eventually affects the possibility of extreme events in North America, quantifying the impact of anthropogenic forcing over less than a week’s forecast simulation. Our study assesses the validity of the storyline approach conditional on the forecast lead times, which is hindered by rising noise in CO2 signals and the declining performance of the forecast model. The forecast-based storyline approach is valid for at least half of the land area within a 6-day lead time before the target extreme occurrence. Our attribution results highlight the importance of achieving net-zero emissions ahead of schedule to reduce the occurrence of severe heatwaves.
Exercise-based interventions targeting balance and falls in people with COPD: a systematic review and meta-analysis
Authors: Loughran Kirsti J. , Emerson Jonathan , Avery Leah , Suri Sophie , Flynn Darren , Kaner Eileen , Rapley Tim , Martin Denis , McPhee Jamie , Fernandes-James Caroline , Harrison Samantha L. 
Published: June 2024

IntroductionThis review quantifies the mean treatment effect of exercise-based interventions on balance and falls risk in people with COPD.MethodsA structured search strategy (2000–2023) was applied to eight databases to identify studies evaluating the impact of exercise-based interventions (≥14 days in duration) on balance or falls in people with COPD. Pooled mean treatment effects (95% confidence intervals (CIs), 95% prediction intervals (PIs)) were calculated for outcomes reported in five or more studies. Inter-individual response variance and the promise of behaviour change techniques (BCTs) were explored.Results34 studies (n=1712) were included. There were greater improvements in balance post intervention compared to controls for the Berg Balance Scale (BBS) (mean 2.51, 95% CI 0.22–4.80, 95% PI −4.60–9.63), Timed Up and Go (TUG) test (mean −1.12 s, 95% CI −1.69– −0.55 s, 95% PI −2.78–0.54 s), Single-Leg Stance (SLS) test (mean 3.25 s, 95% CI 2.72–3.77 s, 95% PI 2.64–3.86 s) and Activities-specific Balance Confidence (ABC) scale (mean 8.50%, 95% CI 2.41–14.58%, 95% PI −8.92–25.92%). Effect on falls remains unknown. Treatment effects were larger in maleversusmixed-sex groups for the ABC scale and SLS test, and in balance trainingversusother exercise-based interventions for the BBS and TUG test. Falls history was not associated with changes in balance. Meta-analysis of individual response variance was not possible and study-level results were inconclusive. Eleven promising BCTs were identified (promise ratio ≥2).ConclusionEvidence for the effect of exercise-based interventions eliciting clinically important improvements in balance for people with COPD is weak, but targeted balance training produces the greatest benefits. Future exercise interventions may benefit from inclusion of the identified promising BCTs.
Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
Authors: Liu Yunpeng , Lu Shuaiyao , Yang Jing , Yang Yun , Jiao Li , Hu Jingwen , Li Yanyan , Yang Fengmei , Pang Yunli , Zhao Yuan , Gao Yanpan , Liu Wei , Shu Pengcheng , Ge Wei , He Zhanlong , Peng Xiaozhong 
Published: June 2024

Abstract
Background
Aging is a prominent risk factor for diverse diseases; therefore, an in-depth understanding of its physiological mechanisms is required. Nonhuman primates, which share the closest genetic relationship with humans, serve as an ideal model for exploring the complex aging process. However, the potential of the nonhuman primate animal model in the screening of human aging markers is still not fully exploited. Multiomics analysis of nonhuman primate peripheral blood offers a promising approach to evaluate new therapies and biomarkers. This study explores aging-related biomarker through multilayer omics, including transcriptomics (mRNA, lncRNA, and circRNA) and proteomics (serum and serum-derived exosomes) in rhesus monkeys (Macaca mulatta).

Results
Our findings reveal that, unlike mRNAs and circRNAs, highly expressed lncRNAs are abundant during the key aging period and are associated with cancer pathways. Comparative analysis highlighted exosomal proteins contain more types of proteins than serum proteins, indicating that serum-derived exosomes primarily regulate aging through metabolic pathways. Finally, eight candidate aging biomarkers were identified, which may serve as blood-based indicators for detecting age-related brain changes.

Conclusions
Our results provide a comprehensive understanding of nonhuman primate blood transcriptomes and proteomes, offering novel insights into the aging mechanisms for preventing or treating age-related diseases.
Primary care doctors in acute call-outs to severe trauma incidents in Norway – variations by rural-urban settings and time factors
Authors: Myklevoll Kristian Rikstad , Zakariassen Erik , Morken Tone , Baste Valborg , Blinkenberg Jesper , Bondevik Gunnar Tschudi 
Published: June 2024

Abstract
Background
A severely injured patient needs fast transportation to a hospital that can provide definitive care. In Norway, approximately 20% of the population live in rural areas. Primary care doctors (PCDs) play an important role in prehospital trauma care. The aim of this study was to investigate how variations in PCD call-outs to severe trauma incidents in Norway were associated with rural-urban settings and time factors.

Methods
In this study on severe trauma patients admitted to Norwegian hospitals from 2012 to 2018, we linked data from four official Norwegian registries. Through this, we investigated the call-out responses of PCDs to severe trauma incidents. In multivariable log-binomial regression models, we investigated whether factors related to rural-urban settings and time factors were associated with PCD call-outs.

Results
There was a significantly higher probability of PCD call-outs to severe trauma incidents in the municipalities in the four most rural centrality categories compared to the most urban category. The largest difference in adjusted relative risk (95% confidence interval (CI)) was 2.08 (1.27–3.41) for centrality category four. PCDs had a significantly higher proportion of call-outs in the Western (RR = 1.46 (1.23–1.73)) and Central Norway (RR = 1.30 (1.08–1.58)) Regional Health Authority areas compared to in the South-Eastern area. We observed a large variation (0.47 to 4.71) in call-out rates to severe trauma incidents per 100,000 inhabitants per year across the 16 Emergency Medical Communication Centre areas in Norway.

Conclusions
Centrality affects the proportion of PCD call-outs to severe trauma incidents, and call-out rates were higher in rural than in urban areas. We found no significant difference in call-out rates according to time factors. Possible consequences of these findings should be further investigated.
Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma
Authors: Wongpattaraworakul Wattawan , Choi Allen , Buchakjian Marisa R. , Lanzel Emily A. , KD Anand Rajan , Simons Andrean L. 
Published: June 2024

Abstract
Background
In oral squamous cell carcinoma (OSCC), the tumor-node-metastasis (TNM) staging system is a significant factor that influences prognosis and treatment decisions for OSCC patients. Unfortunately, TNM staging does not consistently predict patient prognosis and patients with identical clinicopathological characteristics may have vastly different survival outcomes. Host immunity plays an important role in tumor progression but is not included in the TNM staging system. Tumor-infiltrating lymphocytes (TILs) are part of the host immune response that recognizes tumor cells; and the presence of TILs has emerged as potential candidates for prognostic markers for many types of cancers. The present study aims to determine the association of T cell-specific markers (CD3, CD4, CD8, and FOXP3) with clinicopathological characteristics and survival outcomes in OSCC patients. The prognostic value of CD3, CD4, and CD8 will also be evaluated based on tumor stage.

Methods
Tissue microarrays were constructed containing 231 OSCC cases and analyzed by immunohistochemical staining for the expression of CD3, CD4, CD8, and FOXP3. The expression scores for each marker were correlated with clinicopathological parameters and survival outcomes. The prognostic impact of CD3, CD4 and CD8 were further analyzed based on tumor stage (early or advanced).

Results
CD3, CD4, and CD8 were found to be significantly associated with both overall survival and progression-free survival using univariate analysis. However, none of these markers were found to independently predict the survival outcomes of OSCC using multivariate analysis. Only conventional factors such as nodal status, tumor differentiation and perineural invasion (PNI) were independent predictors of survival outcomes, with nodal status being the strongest independent predictor. Additionally, low CD4 (but not CD3 or CD8) expression was found to identify early-stage OSCC patients with exceptionally poor prognosis which was similar to that of advanced staged OSCC patients.

Conclusions
TIL markers such as CD3, CD4, CD8, and FOXP3 can predict the survival outcomes of OSCC patients, but do not serve as independent prognostic markers as found with conventional factors (i.e. nodal status, tumor differentiation and PNI). CD4 expression may assist with risk stratification in early-stage OSCC patients which may influence treatment planning and decision making for early-stage OSCC patients.
Brain and the whole-body bone imaging appearances in Menkes disease: a case report and literature review
Authors: Zhu Juncheng , Liao Yi , Li Xuesheng , Jia Fenglin , Ma Xinmao , Qu Haibo 
Published: June 2024

Abstract
Background
Menkes disease (MD) is a rare, inherited, multisystemic copper metabolism disorder. Classical Menkes disease is characterized by low serum copper and ceruloplasmin concentrations, leading to multiple abnormalities in the whole-body, especially in connective tissue and central nervous system. However, serum copper and ceruloplasmin levels are not reliable diagnostic biomarkers due to the low concentrations in healthy newborns either. The featured imaging manifestations play an important role in diagnosing Menkes disease. To our knowledge, there are few reports on the systemic imaging manifestations of Menkes disease.

Case presentation
A 4-month-old male patient presented with recurrent seizures. He had cognitive, intellectual, growth, gross motor, precision movement, and language developmental lags. The patient’s hemoglobin and serum ceruloplasmin level were low. On MRI, increased intracranial vascular tortuosity, cerebral and cerebellar atrophy, white matter changes, and basal ganglia abnormalities were observed. Plain radiograph revealed wormian bones, rib flaring, metaphyseal spurring, and periosteal reactions in the long bones of the limbs. A pathogenic variant in ATP7A gene was identified in the patient, so he was confirmed the diagnosis of Menkes disease. His symptoms did not improve despite symptomatic and supportive treatment during his hospitalization. Unfortunately, the infant died 3 months after leaving hospital.

Conclusion
A comprehensive and intuitive understanding of the disease’s imaging manifestations can help clinicians to identify the disease and avoid delays in care.