bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of hexavalent chromium removal from aqueous solutions using Eichhornia crassipes-derived adsorbents through a response surface methodology
Authors: Tri Chu Luong , Tung Vo Hoang , Hong Nguyen Thi , Tuan Le , Nguyen Dinh Duc , Nguyen X. Cuong , La D. Duc , Le Duy Khuong 
Published: July 2024

Abstract

Heavy metal contamination, particularly hexavalent chromium (Cr(VI)), in water bodies poses severe environmental and health risks. In recent years, using natural adsorbents for removing heavy metals has gained intensive interest thanks to their eco-friendliness and cost-effectiveness. In this work, lignocellulosic biomass materials were modified and employed as adsorbents to remove Cr(VI) from contaminated water. Adsorbent materials derived from Eichhornia crassipes showed the significance of removing Cr (VI) from the aqueous solution after being treated by H2SO4 acid 1.5% w/v at 45oC for 30 h. After localising the upper and lower limits of each factor, design under the response surface models (RSM) using the Box–Behnken Design (BBD) method was used to optimise enhancement of the removal of Cr(VI). The strategy showcased the ability to construct a second-degree polynomial model that is highly valid (R2˃0.9805) and includes statistically significant interactions (P < 0.05). The findings indicated that the highest capacity for adsorbing Cr(VI) was 41.53 mg/g, which was attained by using 15 g/L of adsorbent, maintaining a pH of 3, starting with a Cr(VI) concentration of 130 mg/L, and allowing a contact duration of 80 minutes.
Mitochondria transfer transiently rescues cerebellar neurodegeneration at early stage by alleviating mitophagy
Authors: Wang Yayun , Li Shu-Jiao , Zheng Qian-Wen , Zheng Jie , Zhang Jin-Bao , Liu Hui , Tie Jing-Jing , Zhang Kun-Long , Wu Feifei , Li Xiaodong , Zhang Shuai , Sun Xin , Yang Yan-Ling 
Published: July 2024

Abstract

Cerebellar ataxia is the main manifestation of cerebellar degenerative diseases, and the mitochondrial function of Purkinje cells (PCs) plays a key role in the disease. And treatments targeting the cerebellum need further research. We constructed a model of cerebellar PCs degeneration, characterized by ataxia, through conditional knockout of Drp1 in PCs (PCKO mice). And we further explored the pathogenesis and possible effective treatment of cerebellar degenerative diseases. Drp1 knockout results in pervasive and progressive apoptosis of PCs, accompanied by severe glial cell activation surrounding them. Mitochondrial dysfunction, as a cause of mitophagy, is a key pathogenic factor of PCs morphological damage and dysfunction. Transfer of liver-derived mitochondria into the cerebellum of PCKO mice at 1 month improved mitochondrial function and reduced mitophagy, resulting in a delay of PCs apoptosis and cerebellar ataxia for 3 weeks. This study demonstrates that mitochondria transfer may be an potential treatment for cerebellar degenerative diseases.
Relationship between peritumoral brain edema and Ki-67 antigen labelling index in intracranial meningiomas
Authors: Mahbub Abdullah Al , Esha Tamanna Ahmed , Rahman Mantaka , Nath Prof. Dr. Haradhan Deb 
Published: July 2024

Abstract

Introduction: The most common benign non-glial cerebral tumor in adults is a meningioma. In roughly 50–78% of instances, peripheral brain edema (PTBE) is a common observation in meningioma, while it may not be present in others. Although the Ki67 proliferation index may be able to predict the recurrence of tumors in meningioma patients, there is a lack of conclusive evidence and relationships.
Objective: To enhance evaluation, correlate the Ki67 index of meningioma patients with peritumoral cerebral edema.
Methods: This cross-sectional study involved 24 patients with meningioma (20 female, 4 male; mean age 39.95 ± 14.54 years). Pre-operative neuroimaging was used to evaluate all patients for the presence of cerebral edema surrounding the lesion using brain MRI and histological confirmation. An immune-histochemical staining known as the Ki-67 index was used to measure proliferative activity. The possibility of a relationship between the levels of the Ki67 index and the existence of PTBE was investigated.
Result: WHO grade I tumors were identified in approximately twenty-three (95.8%) of the patients with PTBE, mean age 39.95 with 14.54 SD and male to female ratio 5:1. Eight patients (33.3%) were classified as GR1patients, one as GR2, and the majority of patients (15/62.5%) as GR0 patients. For G1, the greatest level is represented by the mean value of the Ki-67 Index level, which is 7.00. When compared to gender, tumor location, and meningioma type (p>0.05), the PTBE grading was statistically significant when it came to the Ki-67 indices (p<0.05). Furthermore, the grading of peritumoral edema (PTBE) and the Ki-67 labelling index value exhibited a substantial positive association, as indicated by the spearman correlation test, with a significant p-value <0.05 and a coefficient value of r = 0.647.
Conclusion: Peritumoral brain edema (PTBE)-encircled meningioma had a strong correlation with Ki67 indices.
51 year old patient with Familial Mediterranean fever (FMF), Type 2 Diabetes Mellites (T2DM) and Multiple Sclerosis (MS)- case report
Authors: Tassabehji Omar , Alayoubi Alisar , mansour anas , Arkoub Hussein , Jbeily Rajwa Daowd 
Published: July 2024

Abstract

Familial Mediterranean fever (FMF) is a genetic disorder that follows an autosomal recessive pattern and is characterized by recurrent episodes of febrile peritonitis, synovitis, and pleuritis. Many studies associate FMF with MS1. Multiple Sclerosis is the most common non-traumatic disabling disease affecting young adults.2 The cause of MS remains unclear, since MS is a complex disease, Inflammation, demyelination, and axonal degeneration are the major pathologic mechanisms that cause the clinical manifestations.3 Type 2 Diabetes Mellites( T2DM ) is considered to have the highest prevalence amongst other diseases affecting over 340 million people worldwide4 characterized with resistance to insulin and disrupted function for beta cell istle in the pancreas. Which together result in insufficient supply of insulin5.
our patient is a 51-year-old male, that has FMF and T2DM and recently developed neurological symptoms related to MS, which is a very rare occurrence that urged us to do further testing and imaging which made the diagnosis clear it was MS. All three diseases co existing is the reason we wrote this case report, to shed the light on such abandoned cases for patients who might be diagnosed earlier if got regularly clinical tests.
Evolution of radiology staff perspectives during artificial intelligence (AI) implementation for expedited lung cancer triage
Authors: Togher Daniel , Dean Geraldine , Moon Jo , Mayola Richard , Medina Arman , Repec Jadwiga , Meheux Moesha , Mather Sarah , Storey Mathew , Rickaby Simon , Abubacker Mohamed Ziad , Shelmerdine Susan 
Published: July 2024

Abstract

ObjectivesTo investigate radiology staff perceptions of an AI tool for chest radiography triage, flagging findings suspicious for lung cancer to expedite same day CT chest examination studies.MethodsSurveys were distributed to all radiology staff at three time points: at pre-implementation, one month and also seven months post-implementation of AI. Survey questions captured feedback on AI use and patient impact.ResultsSurvey response rates at the three time periods were 23.1% (45/195), 14.9% (29/195) and 27.2% (53/195) respectively. Most respondents initially anticipated AI to be time saving for the department and patient (50.8%), but this shifted to faster follow-up care for patients after AI implementation (51.7%). From the free text comments, early apprehension about job role changes evolved into frustration regarding technical integration challenges after implmentation. This later transitioned to a more balanced view of recognised patient benefits versus minor ongoing logistical issues by the late post-implementation stage. There was majority disagreement across all survey periods that AI could be considered to be used autonomously (53.3 - 72.5%), yet acceptance grew for personal AI usage if staff were to be patients themselves (from 31.1% pre-implementation to 47.2% post-implementation).ConclusionSuccessful AI integration in radiology demands active staff engagement, addressing concerns to transform initial mixed excitement and resistance into constructive adaptation. Continual feedback is vital for refining AI deployment strategies, ensuring its beneficial and sustainable incorporation into clinical care pathways.
Eksplorasi Nilai-Nilai Pancasila Dalam Memerangi Bullying di Lingkungan Perguruan Tinggi
Authors: Sahrona Sahrona 
Published: July 2024

This study explores the implementation of Pancasila values, specifically justice, tolerance, equitable humanity, mutual cooperation, and wise leadership, in the Pancasila Education course at the higher education level to address bullying cases. The research employs a qualitative method with a phenomenological approach to deeply understand students' comprehension of Pancasila values in this context. The results indicate that the incorporation of these values in the coursework significantly enhances students' understanding, attitudes, and commitment to preventing and addressing bullying on campus. By involving students in learning activities that include discussions, projects, field practices, awareness campaigns, and reflections, character education grounded in Pancasila can serve as a crucial foundation in shaping students with strong social consciousness, preparing them to face future challenges.

Penelitian ini mengeksplorasi pelaksanaan nilai-nilai Pancasila, khususnya nilai keadilan, toleransi, kemanusiaan yang adil, gotong royong, dan kepemimpinan bijaksana, dalam mata kuliah Pendidikan Pancasila pada tingkat perguruan tinggi untuk menanggulangi kasus bullying. Penelitian menggunakan metode kualitatif dengan pendekatan fenomenologi untuk mendalami pemahaman mahasiswa terhadap nilai-nilai Pancasila dalam konteks ini. Hasilnya menunjukkan bahwa pelaksanaan nilai-nilai tersebut dalam perkuliahan secara signifikan meningkatkan pemahaman, sikap, dan komitmen mahasiswa dalam mencegah dan mengatasi bullying di lingkungan kampus. Dengan melibatkan mahasiswa dalam kegiatan pembelajaran yang mencakup diskusi, proyek, praktik lapangan, kampanye kesadaran, dan refleksi, pendidikan karakter yang kuat didukung oleh Pancasila dapat menjadi landasan penting dalam membentuk mahasiswa yang memiliki jiwa sosial yang kuat dan siap menghadapi tantangan di masa depan.
Design storm parameterisation for urban drainage studies derived from regional rainfall datasets: A case study in the Spanish Mediterranean region
Authors: Balbastre-Soldevila Rosario , Andrés-Doménech Ignacio , García-Bartual Rafael 
Published: July 2024

ABSTRACT

A significant amount of information on regional rainfall characteristics is available nowadays, allowing its use in hydrological applications. This article is motivated by the availability of regional studies regarding maximum daily rainfall and intensity–duration–frequency curves that can be coupled with the design storm concept for urban hydrology studies. This is accomplished through a convenient index describing temporal variability of rainfall. More precisely, a methodology for regionalising the two parameters (i0, φ) of the two-parameter gamma design storm (G2P) is developed herein. A three-step methodology is proposed for obtaining the two parameters (i0, φ) for a given location. The results obtained in a case study show coherence with previous studies concerning maximum rainfall statistics.
Review paper on applications of the HEC-RAS model for flooding, agriculture, and water quality simulation
Authors: Zainal Norsaliha Najwa , Abu Talib Siti Hidayah 
Published: July 2024

ABSTRACT
The Hydrologic Engineering Center (HEC) of the United States Army Corps of Engineers (USACE) has developed the HEC-River Analysis System (RAS) hydraulic channel flow model as part of its portfolio of hydrologic and hydraulic modeling tools. HEC-RAS is a new version with capabilities to model flooding, modeling for agriculture production computations for water quality, and many more related to hydraulic modeling. The analysis components of the HEC-RAS system include one-dimensional steady flow water surface profile computations, one-dimensional and or two-dimensional unsteady flow simulation, one-dimensional and two-dimensional computations of quasi-unsteady or fully unsteady flow movable boundary sediment transport, and one-dimensional water quality analysis. The main objective of this paper is to review the use of HEC-RAS on flooding, agriculture, and water quality. The three primary components of the data input are plan data, geometry data, and flow data. Three of these scenarios applied to HEC-RAS and were proven by previous reviewers.
Tax aggressiveness in a scenario of economic crisis and financial difficulty: an analysis of companies listed on B3
Authors: Ferreira Cássia de Oliveira , Carvalho Laiz de Fátima , Carvalho Otávio Araújo de , Cunha Jacqueline Veneroso Alves da 
Published: July 2024

Objective: This study aimed to examine the relationship between economic crisis scenarios, financial difficulties, and tax aggressiveness in companies listed on B3.
Methodology: This descriptive and documentary study employed a quantitative approach, incorporating a sample of 326 companies. Data analysis entailed using descriptive statistics and regression analysis with panel data.
Results: The findings of this study suggest that a crisis environment does not promote the adoption of aggressive tax strategies by the companies within the sample. This contradicts established literature, which has posited that there is a heightened effort to decrease tax liability during periods of crisis. Nonetheless, it was observed that companies experiencing financial difficulties tend to adopt aggressive tax strategies in an effort to alleviate their tax burdens.
Study Contributions: This research aims to contribute to discussing tax aggressiveness among Brazilian companies during economic crises, pointing out discrepancies with previous studies. Additionally, it seeks to broaden the understanding of tax aggressiveness in situations of crisis and financial difficulty, thereby enhancing the body of knowledge in the tax domain.
Nigella sativa Oil-loaded Ethanolic Vesicular Gel for Imiquimod-induced Plaque Psoriasis: Physicochemical Characterization, Rheological Studies, and In vivo Efficacy
Authors: Vihal Samar , Pundir Swati , Rathore Charul , Ranjan Lal Uma , Gupta Gaurav , Kumar Singh Sachin , Dua Kamal , Kumar Chellappan Dinesh , Negi Poonam 
Published: July 2024

Background:
The therapeutic effect of NS oil in mild to moderate psoriasis is limited owing
to low play load of thymoquinone (<15 %w/w), irritation, dripping, low viscosity and thus, less
contact time on the lesions.

Aims::
This study aimed at developing and characterizing the ethanolic vesicular hydrogel system of
Nigella sativa (NS) oil (NS EV hydrogel) for the enhancement of anti-psoriatic activity.

Objective:
The objective of this study was to develop NS EV hydrogel and evaluate its anti-psoriatic
activity.

Methods:
The identification and quantification of TQ content in different NS seed extracts and marketed
oil were measured by an HPTLC method using n-hexane and ethyl acetate as solvent systems.
Preparation of ethanolic vesicles (EVs) was performed by solvent injection method, while its antipsoriatic
activity was evaluated employing an Imiquad (IMQ)-induced plaque psoriasis animal model.

Results:
A compact HPTLC band was obtained for TQ at an Rf value of 0.651. The calibration plot
was linear in the range of 1-10 μg/spot, and the correlation coefficient of 0.990 was indicative of
good linear dependence of peak area on concentration. From the different NS sources, the high TQ
content was obtained in the marketed cold press oil, i.e., 1.45±0.08mg/ml. Out of various NS oilloaded
EVs, the F6 formulation revealed the smallest particle size (278.1nm), with log-normal size
distribution (0.459) and adequate entrapment efficiency. A non-uniform shape was observed in the
transmission electron microscopy. The viscosity of F6 formulation hydrogel was 32.34 (Pa·s), which
exhibited plastic behavior. In vivo, efficacy studies demonstrated decreased inflammation of the epidermis
and dermis and a marked decrease in the levels of IL-17 by NS EV hydrogel compared to
plain NS oil and standard drugs (Betamethasone and Dr. JRK Psorolin Oil).

Conclusion:
It may be concluded from the findings that NS-loaded EV gel was as good as betamethasone
cream but more efficacious than the other treatments.
Karakteristik Sabun Padat Pada Perlakuan Penambahan Penstabil Tween 80
Authors: Viani Sofia Charlotie , Putranti Jessica Ayuningtyas , Jelau Kaprianto , Wrasiati Luh Putu 
Published: July 2024

The research conducted sought to determine the impact of the addition and amount of tween 80 to obtain the best solid soap characteristics. This research is a one-factor experimental study, namely the percentage of tween 80 addition (0%, 0.25%, 0.5%, 0.75%, and 1%). The results showed that the addition of tween 80 had a significant effect on the hardness, pH, foam, moisture, firmness, brightness (L*), and yellowness (b*) of solid soap, but had no significant effect on redness (a*) and foam stability. Increasing the level of tween in the mixture will cause the moisture of the foam to increase, resulting in a firmer, higher pH, brighter and more yellow color intensity. The conclusion based on the data encountered by the author is that the solid soap added with tween 80 as much as 0.75% has the best characteristics, referring to the physicochemical data which shows the results of foam with a pH of 10.45 ± 0.49, foam stability of 85.67 ± 3.30, texture of 22.38 ± 0.70, level of brightness (L*) 86.35 ± 0.354, level of redness (a*) 0.95 ± 0.636, and level of yellowness (b*) 2.7 ± 0.141. As for the organoleptic test (scoring and hedonic), panelists prefer soap with the treatment of adding 1% tween 80 showing the highest value, namely the foam is rated 4.75 ± 0.44, the stickiness is 4.45 ± 0.89, the humidity is 4.45 ± 0.69, and the overall acceptance is 5.95 ± 0.83.
Keywords : tween 80, characteristics, solid soap
Penelitian yang dilakukan berupaya menentukan dampak penambahan dan jumlah tween 80 untuk mendapatkan karakteristik sabun padat terbaik. Penelitian ini adalah studi eksperimental satu faktor, yaitu persentase penambahan tween 80 (0%, 0,25%, 0,5%, 0,75%, dan 1%). Adapun beberapa bahan dalam penelitian pembuatan sabun padat ini diantaranya yakni air, NaOH, coconut oil, serta tween 80. Hasil penelitian menunjukkan bahwa penambahan tween 80 memiliki pengaruh signifikan terhadap kekerasan, pH, busa, kelembaban, kekesatan, kecerahan (L*), dan kekuningan (b*) sabun padat, tetapi tidak memiliki pengaruh signifikan terhadap kemerahan (a*) dan stabilitas busa. Peningkatan kadar tween didalam campuran akan menyebabkan kelembapan busa meningkat, sehingga hasilnya lebih kesat, pH lebih tinggi, intensitas warna lebih cerah dan lebih kuning. Kesimpulan berdasarkan data yang ditemui penulis yakni sabun padat yang ditambahkan tween 80 sebanyak 0,75% memiliki karakteristik paling baik, mengacu pada data fisikokimianya yang menunjukkan hasil busa dengan pH 10,45±0,49, stabilitas busa 85,67±3,30, tekstur 22,38±0,70, tingkat kecerahan (L*) 86,35±0,354, tingkat kemerahan (a*) 0,95±0,636, serta tingkat kekuningan (b*) 2,7±0,141. Adapun untuk uji organoleptik (skoring dan hedonik), panelis lebih memilih sabun dengan perlakuan ditambahkannya tween 80 1% menunjukkan nilai paling tinggi yakni busanya dinilai 4,75±0,44, kekesatan sebesar 4,45±0,89, kelembaban 4,45±0,69, dan penerimaan keseluruhan sebesar 5,95±0,83.
Kata kunci : tween 80, karakteristik, sabun padat
Commercial, Cultural and Social Aspects of Related to the Winegrowing Sector
Authors: Souza Karen Letícia , Gil Henric Pietro Vicente , Carmo Reginaldo Divino do , Coelho Ricardo Limongi França , Barbosa Alverne Passos , Gil Eric de Souza 
Published: July 2024

Objective: The objective of this review study is to investigate the trends and preferences of wine consumers globally, evaluating social and cultural aspects, marketing strategies, sensory perceptions, in addition to studying pricing and marketing linked to winemaking.

Theoretical Framework: To understand the aspects of the desired objectives, research was carried out in several academic works addressing the aforementioned themes that, for better organization and understanding, were divided into three interrelated categories: consumer behavior, multisensory perception and wine pricing.

Method: The methodology adopted for this research comprises the literature revision from 1995 to 2024, taking into account the key words wine princing, wine consumers, willingness to pay, wine attributes, wine quality, sensory drivers.

Results and Discussion: By evaluating publications from various geographic regions and synthesizing them, it was possible to understand the regional nuances and particularities and the weight they present in the global winemaking framework. Consumer behavior is seen as being a consequence of social and cultural aspects, influenced by sensory perceptions, price, brand and expertise, among others. The studies evaluated indicate that multisensory perception is related to sensory stimuli and the way they interact, enabling a sensorial experience for the consumer, adding up to another important parameter influencing the consumer in their choices. Regarding the issue of wine pricing, studies point to conceivable factors such as vintage, origin, bottle design, quality assessments by experts, being factors that impact wine pricing.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of wine sector. These implications could encompass the main sensorial attributes that drives the wine pricing.

Originality/Value: This study contributes to the literature by bringing the main aspects related to willing to pay for wines. The relevance and value of this research are evidenced by anthropological and psico social. This study brings a synthesis of several academic studies related to winemaking and its social and cultural aspects, covering consumer behavior, sensory perceptions and wine pricing, perceptions that guide the production chain and consumers from experts to beginners in order to expand the knowledge of all aspects involving winemaking.