bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Retrospective Review Comparing Renuvion Helium Plasma Radiofrequency with BodyTite Bipolar Radiofrequency after Liposuction or Body Contouring
Authors: Kluska Michael , Deal R. Chad , Summers Kyle , Chang Steven 
Published: August 2024

Background:
Driven by demand for nonexcisional alternatives to address lax skin following liposuction, various energy-based technologies have become available. Helium plasma radiofrequency (RF) and bipolar RF have gained prominence. These technologies have distinctly different methods of action and indications, potentially influencing procedural safety and duration.

Methods:
Conducted to collect and evaluate real-world procedure and safety data, this retrospective, single-center, contiguous series study included patients who underwent either helium plasma RF or bipolar RF following a liposuction or body contouring procedure.

Results:
The helium plasma RF group (N = 229) averaged 4.9 concurrent procedures, whereas the bipolar RF group (N = 236) averaged 4.4 concurrent procedures. The total treatment time, including concurrent procedures, was 182 minutes for the helium plasma RF group and 196 minutes for the bipolar RF group. The findings from the subanalysis group (n = 9) indicated that the treatment time for the helium plasma RF side of the body was 50% shorter than the bipolar RF side. A statistically significant difference in adverse events by group was observed. There were 45 events in 34 patients for helium plasma RF and 93 events in 62 patients for bipolar RF. Notably, fewer occurrences of burns, hematoma, hypertrophic scar, and seroma were reported for helium plasma RF compared with bipolar RF.

Conclusions:
The analysis reveals a notable difference in the occurrence of adverse events, with statistically significantly fewer incidents observed for helium plasma RF compared with bipolar RF. Data suggests that helium plasma RF exhibits shorter durations in the operating room compared with bipolar RF, suggesting increased procedural efficiency.
Customized Negative Pressure Wound Therapy: Innovative Design in Polyurethane Foam for Complex Burn Reconstruction
Authors: Amaris-Acuña Juan Sebastián , Mendoza-Toro Bibiana , Camacho-Obando David , Gómez-Ortega Viviana 
Published: August 2024

Summary:
The use of negative pressure wound therapy (NPWT) throughout the entire treatment of a burn patient boosts wound healing and recovery. Hand burns require specialized management that enhances wound healing and facilitates early physical rehabilitation. Thus, this article showcases a novel idea of NPWT foam customization that boosts recovery and rehabilitation in patients with hand burns. We present two patients with hand burns treated with NPWT using a customized foam design that allowed for early rehabilitation while providing and optimized recovery. In the two cases presented, the patients required two surgical stages; in the first surgery, debridement of the burns was performed and customized NPWT with instillation was applied, and in the second surgical stage, the bed was reconstructed with partial-thickness skin grafts, which were bolstered with customized conventional NPWT. The management, reconstruction, and rehabilitation were accomplished in under 2 weeks, achieving a remarkable 100% success rate in graft integration during the acute phase on the first attempt. This highlights the effectiveness of incorporating NPWT across all burn treatment phases, expediting recovery and ensuring optimal functional outcomes for patients. Surgeons can customize different NPWT foam shapes that facilitate its use on difficult-to-treat areas, allowing for a faster recovery and better rehabilitation outcomes.
Suitability and Early Clinical Outcomes of Corneal Donor Tissue in the 76–80-Year-Old Age Group
Authors: Greenwald Miles F. , Sawant Onkar B. , Titus Michael S. , Ballouz Dena , Hood Christopher T. , Mian Shahzad I. 
Published: August 2024

Purpose:
There is a significant global shortage of corneal donor tissue suitable for keratoplasty. One simple strategy for addressing this shortage is to increase the upper age limit for acceptable tissue over the current customary upper limit of age 75. We describe a pilot study completed at one eye bank procuring, processing, and distributing keratoplasty tissue from donors aged 76 to 80 years.

Methods:
This is a retrospective case series of donor tissues aged 76 to 80 years in comparison with donor tissues aged 71 to 75 years. Standard tissue parameters were evaluated for all tissues, including tissue suitability, mean endothelial cell density (ECD), death-to-procurement time, and cause of death. For the older tissues, clinical outcomes through 3 months were obtained from each surgeon, including intraoperative and postoperative complications.

Results:
Corneal tissues from donors aged 76 to 80 years had a similar suitability rate (57%) when compared with donors aged 71 to 75 years (59%) (P = 0.635). Both groups had comparable ECDs (P = 0.097). Early clinical outcomes of corneal grafts from donors older than 76 years were favorable, with no early graft failure or significant concerns for clinical safety or efficacy.

Conclusions:
Our findings suggest that corneal tissues aged 76 to 80 years can be safely and efficiently transplanted in the United States. While additional study is needed, our results strengthen the case that expanding the upper age limit for donor age has the potential to help meet the global shortage for suitable keratoplasty tissue.
Characterization of vault with two models of posterior chamber phakic intraocular lenses
Authors: Paredes Beatriz , Mora de Oñate Javier , Martín Sánchez Dolores , Piñero David P. 
Published: August 2024

Purpose:
To evaluate and compare dynamic vault range (DVR) and asymmetry of the vault during a 3-month follow-up after the implantation of 2 posterior chamber phakic intraocular lenses (pIOLs).

Setting:
Aver Clinic, Madrid, Spain.

Design:
Prospective comparative study.

Methods:
119 eyes (65 patients) that underwent refractive surgical correction with implantation of 1 of 2 distinct pIOLs were enrolled: Eyecryl Phakic from Biotech Vision Care (Eyecryl group, 72 eyes) and Evo Visian Implantable Contact Lens from Staar Surgical (ICL group, 47 eyes). Besides evaluation of visual acuity, refraction, and ocular integrity, the pIOL vault centrally and at 2 mm nasally and temporally as well as the DVR from photopic (50 lux) to mesopic (10 lux) illumination conditions were measured.

Results:
No significant differences were found between the pIOL groups in visual and refractive outcomes (P ≥ .454). No significant differences between the groups were found in central (523.72 ± 168.4 vs 494.16 ± 156.7 μm, P = .248) and temporal (499.43 ± 155.8 vs 431.28 ± 150.5 μm, P = .067) vaults. However, nasal vault was significantly lower in the ICL group (465.6 ± 149.1 vs 375.4 ± 144.0 μm, P = .045). A trend of a larger DVR was observed in the ICL group, although differences between groups did not reach statistical significance (54.00 ± 36.39 vs 86.5 ± 57.9 μm, P = .070). The pIOL diameter only correlated significantly with vault measurements in the ICL group (r ≥ 0.650, P < .001).

Conclusions:
The Eyecryl pIOL showed more symmetric vaults and a trend of fewer light-induced changes in the central vault compared with the ICL pIOL. The clinical relevance of this finding should be investigated further.
Emergent epileptiform activity in spinal sensory circuits drives ectopic bursting in afferent axons and sensory dysfunction after cord injury
Authors: Bryson Matthew , Kloefkorn Heidi , Idlett-Ali Shaquia , Carrasco Dario I. , Noble Donald James , Martin Karmarcha , Sawchuk Michael A. , Au Yong Nicholas , Garraway Sandra M. , Hochman Shawn 
Published: August 2024

Abstract
Spinal cord injury leads to hyperexcitability and dysfunction in spinal sensory processing. As hyperexcitable circuits can become epileptiform, we explored whether such activity emerges in a thoracic spinal cord injury (SCI) contusion model of neuropathic pain. Recordings from spinal sensory axons in multiple below-lesion segmental dorsal roots demonstrated that SCI facilitated the emergence of spontaneous ectopic burst spiking in afferent axons, which were correlated across multiple adjacent dorsal roots. Burst frequency correlated with behavioral mechanosensitivity. The same bursting events were recruited by afferent stimulation, and timing interactions with ongoing spontaneous bursts revealed that recruitment was limited by a prolonged post-burst refractory period. Ectopic bursting in afferent axons was driven by GABAA receptor activation, presumably by conversion of subthreshold GABAergic interneuronal presynaptic axoaxonic inhibitory actions to suprathreshold spiking. Collectively, the emergence of stereotyped bursting circuitry with hypersynchrony, sensory input activation, post-burst refractory period, and reorganization of connectivity represent defining features of an epileptiform network. Indeed, these same features were reproduced in naive animals with the convulsant 4-aminopyridine (fampridine). We conclude that spinal cord injury promotes the emergence of epileptiform activity in spinal sensory networks that promote profound corruption of sensory signaling. This includes hyperexcitability and bursting by ectopic spiking in afferent axons that propagate bidirectionally by reentrant central and peripheral projections as well as sensory circuit hypoexcitability during the burst refractory period. More broadly, the work links circuit hyperexcitability to epileptiform circuit emergence, further strengthening it as a conceptual basis to understand features of sensory dysfunction and neuropathic pain.
“Where No One Has Gone Before”: Questions to Ensure the Ethical, Rigorous, and Thoughtful Application of Artificial Intelligence in the Analysis of HIV Research
Authors: Bergman Alanna J. , McNabb Katherine C. , Relf Michael V. , Dredze Mark H. 
Published: August 2024

Abstract
ChatGPT, an artificial intelligence (AI) system released by OpenAI on November 30th, 2022, has upended scientific and educational paradigms, reshaping the way that we think about teaching, writing, and now research. Since that time, qualitative data analytic software programs such as ATLAS.ti have quickly incorporated AI into their programs to assist with or even replace human coding. Qualitative research is key to understanding the complexity and nuance of HIV-related behaviors, through descriptive and historical textual research, as well as the lived experiences of people with HIV. This commentary weighs the pros and cons of the use of AI coding in HIV-related qualitative research. We pose guiding questions that may help researchers evaluate the application and scope of AI in qualitative research as determined by the research question, underlying epistemology, and goal(s). Qualitative data encompasses a variety of media, methodologies, and styles that exist on a spectrum underpinned by epistemology. The research question and the data sources are informed by the researcher's epistemological viewpoint. Given the heterogeneous applications of qualitative research in nursing, medicine, and public health there are circumstances where qualitative AI coding is appropriate, but this should be congruent with the aims and underlying epistemology of the research.
A rare case report: Brucellosis as an extreme cause of shoulder subluxation and rotator cuff tendinopathy
Authors: Tang Bo , Fan Cheng 
Published: August 2024

Rationale:
Shoulder subluxation and rotator cuff tendinopathy is commonly associated with degeneration or trauma, and brucellosis has been reported to be correlated with shoulder subacromial bursitis, arthritis. However, brucellosis as a cause of shoulder subluxation and rotator cuff tendinopathy has never been reported in the English medical literature.

Patient concerns:
A 46-year-old man complained of left shoulder weakness and limited movement ongoing for 1 month. He was primarily diagnosed with shoulder subluxation and rotator cuff tear based on magnetic resonance imaging, and was advised to undergo arthroscopic rotator cuff surgical repair.

Diagnoses:
Although rotator cuff tear was diagnosed in another hospital, some doubts remained. First, a tendon profile with a relative high signal in T2-weighted magnetic resonance images in the supraspinatus tear area still existed. The findings were clearly different from the usual full-thickness rotator cuff tear, and no tendon profile could be found in the tear area. Second, degenerative rotator cuff tear mainly occurs in the aged population and this patient was relatively young, without a history of trauma. His left shoulder was painless but the weakness and the limited movement were extreme and all of these factors did not support the diagnosis of rotator cuff tear. Some infectious disease was suspected to be the cause and relevant laboratory tests were conducted. This patient was eventually diagnosed as having brucellosis-associated shoulder subluxation and rotator cuff tendinopathy based on positive serum standard tube agglutination test and buffer plate agglutination test for brucellosis.

Interventions:
Oral drug therapy with rifampicin and doxycycline was used for 8 weeks.

Outcomes:
A complete response with normal shoulder strength and movement was achieved at 8 weeks. At the one-year follow-up no signs of recurrence were detected.

Lessons:
Brucellosis-associated shoulder subluxation and rotator cuff tendinopathy may be misdiagnosed as a rotator cuff tear in magnetic resonance imaging and be further managed with indeterminate arthroscopic repair. A comprehensive understanding of the patient’s previous medical history, imaging and laboratory data and a careful physical examination are of great clinic value for the accurate diagnosis of the condition and the subsequent prognosis of the patient.
Towards a minimum data set for the female stress urinary incontinence surgical literature: a collaborative work
Authors: Rovner Eric S. 
Published: August 2024

Purpose of review
There has been a need for an acceptable common minimum data set in the scientific literature as regards the surgical treatment of female stress urinary incontinence (SUI). Such a data set, if widely adopted, would improve the quality of the literature and allow objective comparisons between and across interventions.

Recent findings
The surgical treatment of female stress urinary incontinence has evolved considerably over the past few decades. The corresponding body of literature has grown exponentially describing the outcomes of hundreds of studies of these novel interventions. However, historically, the literature in this space has been of uneven quality. In order to improve the reporting of clinical studies, and ultimately patient outcomes, a standard minimum data set for trial design and publications was created by a collaborative group formed from leading scientific societies.

Summary
The consensus document created from this novel collaboration between members of SUFU (Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction), AUGS (American Urogynecologic Society), and ICS (International Continence Society) provides clear guidance for the structure of clinical studies and reporting of results in the peer-reviewed literature. This has substantial potential ramifications for scientific journals, journal editors, peer reviewers, investigators, regulatory agencies, industry, clinicians, and patients.
Mixed reality-supported near-infrared photoimmunotherapy for oropharyngeal cancer: a case report
Authors: Okada Ryuhei , Ito Taku , Kawabe Hiroaki , Tsutsumi Takeshi , Asakage Takahiro 
Published: August 2024

Introduction and importance:
Near-infrared photoimmunotherapy (NIR-PIT, Alluminox) uses an antibody-photoabsorber conjugate and light excitation, requiring precise illumination. Mixed reality (MR) technology can enhance medical procedures through advanced visualization and planning.

Case presentation:
An 86-year-old man with recurrent oropharyngeal cancer and right cervical metastasis received NIR-PIT. Three-dimensional models from computed tomography (CT) and FDG-PET/CT images were used as holograms on a head-mounted display (HMD) for precise light targeting.

Clinical discussion:
HMD-MR technology was utilized for preoperative simulation and guided ideal light direction during surgery. This improved the effectiveness of NIR-PIT.

Conclusion:
Three months post-treatment, no residual lesion was observed, demonstrating the utility of HMD-MR technology in optimizing NIR-PIT outcomes.
Respiratory viral infections in children with cancer and febrile neutropenia and children undergoing hematopoietic stem cell transplantation
Authors: Torres Juan P. , Santolaya María E. 
Published: August 2024

Purpose of review
The scope of this review is to understand the epidemiology and potential role of respiratory viral infections in children with cancer and febrile neutropenia, as well as in children, undergoing hematopoietic stem cell transplantation. Early detection of respiratory viral infections through molecular diagnostic techniques has allowed recent randomized clinical studies to advance the possibility of more rational use of antimicrobials in this susceptible population.

Recent findings
Progress has been made in the early detection of respiratory viruses in episodes of fever and neutropenia in children with cancer. In selected patients who meet specific clinical safety criteria and have negative bacterial cultures, it has been possible to safely and effectively discontinue antimicrobials. This has been validated in recent randomized clinical studies. However, more evidence is still needed for a similar indication in children, undergoing hematopoietic stem cell transplantation with viral respiratory infection episodes.

Summary
Understanding the role of respiratory viral infections in populations of immunocompromised children may contribute to a more rational use of antimicrobials and, in the near future, may help to decrease antimicrobial resistance in this susceptible population.
New antibiotics in clinical pipeline for treating infections caused by metallo-β-lactamases producing Gram-negative bacteria
Authors: Bassetti Matteo , Vena Antonio , Larosa Barbara , Giacobbe Daniele Roberto 
Published: August 2024

Purpose of review
To discuss novel antibiotics under clinical development, focusing on agents showing in-vitro activity against metallo-β-lactamases (MBL)-producing carbapenem-resistant Gram-negative bacteria (CR-GNB).

Recent findings
Currently, only a few approved agents show activity, alone or in synergistic combinations, against MBL-producing CR-GNB. If approved by regulatory agencies in case of favorable results from ongoing (and, for some agents, already completed) phase-3 studies, some novel β-lactam/β-lactamase inhibitor (BL/BLI) combinations could become available in the next few years as additional important options for treating MBL-producing CR-GNB infections. Additional interesting agents that belong both to BL/BLI combinations and to antibiotic classes other than BL and BL/BLI combinations have also shown activity against MBL-producing CR-GNB, with most of them being in early phases of clinical development.

Summary
Improving the use of these novel agents through virtuous antimicrobial stewardship frameworks able to guarantee both the efficacious treatment of infections requiring their use and the avoidance of their use whenever not necessary remains a challenge of utmost importance that should not be overlooked.
Dynamic landscape of a competing endogenous RNA network in early-onset preeclampsia under hypoxia conditions
Authors: Wei Chun-Yan , Hu Xiao-Lin 
Published: August 2024

Objective:
Early-onset preeclampsia (EOPE) manifests as elevated blood pressure and indications of organ damage, predominantly in the kidneys, in women before 34 weeks of gestation. A growing body of evidence suggests that hypoxia triggers a series of maladaptive responses culminating in the progression of EOPE. However, the precise mechanisms underlying these processes remain largely undefined. This study aimed to map the dynamic interplay within the competing endogenous RNA (ceRNA) network in EOPE under hypoxic conditions to provide insights into its molecular etiology.

Methods:
To investigate the oxidative stress response in EOPE, RNA sequencing data (ID: GSE119265) were retrieved from the Gene Expression Omnibus database for exhaustive analysis. Oxygen-sensitive differentially expressed genes (DEGs) were identified by comparing EOPE samples to controls at 5% and 20% O2 concentrations, respectively. Furthermore, the STRING database facilitated the construction of a protein–protein interaction network, highlighting critical hub genes among the identified DEGs.

Results:
An intricate ceRNA network encompassing four representative DEGs (AOC1, DCN, TGFB1, and SYNE3) and seven differentially expressed long non-coding RNAs (HCG27, MEG3, XIST, LINC01119, LINC00964, LINC01118, and LINC01588) was established.

Conclusions:
Our analysis revealed a set of long non-coding RNA that respond to hypoxic stress, shedding light on their possible roles in the oxygen-dependent pathophysiology of EOPE. These insights offer new avenues for targeted EOPE diagnosis and treatment. Further studies are required to elucidate their precise functions.
Omitting the Escalating Dosage of Alpha-adrenergic Blockade Before Pheochromocytoma Resection
Authors: Holscher Isabelle , Engelsman Anton F. , Dreijerink Koen M.A. , Hollmann Markus W. , van den Berg Tijs J. , Nieveen van Dijkum Els J.M. 
Published: August 2024

Objective:
This study describes the effects of introducing a protocol omitting preoperative α-blockade dose-escalation (de-escalation) in a prospective patient group.

Background:
The decline of mortality and morbidity associated with pheochromocytoma resection is frequently attributed to the introduction of preoperative α-blockade. Current protocols require preoperative α-blockade dose-escalation and multiple-day hospital admissions. However, correlating evidence is lacking. Moreover, recent data suggest equal perioperative safety regardless of preoperative α-blockade escalation.

Methods:
Single-institution evaluation of protocol implementation, including patients who underwent adrenalectomy for pheochromocytoma between 2015 and 2023. Intraoperative hemodynamic control was regulated by active adjustment of blood pressure using vasoactive agents. The primary outcome was intraoperative hypertension, defined as the time-weighted average of systolic blood pressure (TWA-SBP) above 200 mm Hg. Secondary outcomes included perioperative hypotension, postoperative blood pressure support requirement, hospital stay duration, and complications.

Results:
Of 102 pheochromocytoma patients, 82 were included; 44 in the de-escalated preoperative α-adrenergic protocol and 38 following the previous dose-escalation protocol. Median [IQR] TWA-SBP above 200 mm Hg was 0.01 [0.0–0.4] mm Hg in the de-escalated group versus 0.0 [0.0–0.1] mm Hg in the dose-escalated group (P=0.073). The median duration of postoperative continuous norepinephrine administration was 0.3 hours [0.0–5.5] versus 5.1 hours [0.0–14.3], respectively (P=0.003). Postoperative symptomatic hypotension occurred in 34.2% versus 9.1% of patients (P=0.005). Median hospital stay was 2.5 days [1.9–3.6] versus 7.1 days [6.0–11.9] (P<0.001). No significant differences in complication rates were observed.

Conclusion:
Our data suggest that adrenalectomy for pheochromocytoma employing a de-escalated preoperative α-blockade protocol is safe and results in a shorter hospital stay.