bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ideias da Arquitectura Portuguesa em viagem
Authors: Silva Cristina Emília , Furtado Gonçalo 
Published: October 2015

Português No presente artigo, propomo-nos delinear alguns itinerários que a Arquitectura Portuguesa percorreu fora do território nacional e identificar os protagonistas com quem viajou rumo ao reconhecimento internacional que detém actualmente. Referência será feita a casos como Eduardo Anahory e a publicação World Architecture em Inglaterra, entre outras da década de 50 e 60. Expor-se-á como as viagens do arquitecto Nuno Portas e o interesse de arquitectos e editores do Sul da Europa, como por exemplo Oriol Bohigas, Vittorio Gregotti, Bruno Alfieri ou Bernard Huet, oriundos de Espanha, Itália e França, ou os encontros em seminários com a presença de nomes como Aldo Rossi, entre outros, fizeram do ano de 1976 um ano de autêntica viragem, de colocação da Arquitectura Portuguesa sob os holofotes da cena internacional arquitectónica. Em grande medida, os arquitectos Portugueses mostraram e ensinaram então, aos seus congéneres internacionais, hipóteses de saídas para a chamada Crise do Movimento Moderno. E, seriam necessários poucos anos, para que passássemos de uma situação de ser forçados a sair, para atrairmos outros a viajarem ao interior do nosso País e Arquitectura. Inglês The present article aims at presenting some of the itineraries that the Portuguese Architecture has gone through abroad while identifying the main protagonists it travelled with towards the achievement of a widely international recognition. It will be referred cases like Eduardo Anahory and the World Architecture edition in England, among others of the 50s and 60s. The importance of trips taken by the architect Nuno Portas and the interest of architects and editors from South of Europe like, for instance, Oriol Bohigas, Vittorio Gregotti, Bruno Alfieri or Bernard Huet, from Spain, Italy and France, or the meetings and seminars arranged by and with the presence of relevant names like Aldo Rossi, among others contributed decisively to make the year of 1976 a turning point. The international attention was focussed on the Portuguese Architecture putting it under the lights of the international architectural scene. The Portuguese architects showed and taught then to their international colleagues, possibilities for the solution of the so-called Crisis of the Modern Movement. Within a few years, the situation was reversed: it was our turn to attract them to visit our country and to know its Architecture.
Alexandre Alves Costa: A Viagem
Authors: Costa Alexandre Alves 
Published: October 2015

Esta é uma exposição que corresponde ao desafio que o Departamento de Arquitectura da FCTUC lançou ao Professor Alexandre Alves Costa para comissariar e conceber uma mostra subordinada ao tema “a minha Escola”.
Com o título Alexandre Alves Costa: a Viagem. À memória de Fernando Távora, percorre os caminhos que consolidam a memória e a identidade do Departamento, na altura em que celebra os vinte anos de existência, mas, acima de tudo, oferece-nos um contributo essencial para reflectirmos sobre a actual condição da arquitectura, no contexto universitário.
Alexandre Alves Costa, Professor Jubilado Catedrático da Faculdade de Arquitectura do Porto e Professor Catedrático Convidado do DARQ, é hoje uma referência fundamental do ensino da arquitectura. Os princípios orientadores da sua actividade pedagógica constroem-se e consolidam-se ao longo de um percurso que privilegia a história como matriz cultural e ontológica das práticas arquitectónicas. O Projecto e a História da Arquitectura são as áreas às quais, preferencialmente, se tem dedicado.
Esta exposição é uma estação desse percurso. Talvez mesmo por essa razão, é concebida como uma VIAGEM pelos seus interesses, pelos seus temas de ensino, pelas suas escolas. Mas é também um VIAGEM através da sua relação com o Professor Arquitecto Fernando Távora, uma relação que, em grande medida, foi consolidada em Coimbra, na construção do que é hoje o Departamento de Arquitectura.
The albertian meaning of 'villa'. A reading key for the rehabilitation of the “montes” alentejanos.
Authors: Moreia e Sá Mariana Ramos 
Published: October 2015

PT Observe-se o título: o termo “montes” encontra-se entre aspas devido à presente dificuldade em encontrar uma designação própria que permita caracterizar o objecto de estudo do Projecto de Investigação de Doutoramento em curso. Esta dificuldade surge pela existência de três realidades distintas em contexto alentejano: ‘quinta’, ‘monte’ e ‘herdade’. De forma a encontrar um nome para intitular esta realidade arquitectónica do mundo rural, recorreu-se à tradução, enquanto processo próprio de investigação: a tratadística clássica foi chamada a informar a contemporânea. Assim, percebeu-se que seria pertinente estudar o tratado ‘De Re Ædificatoria’ de Leon Battista Alberti, uma vez que caracteriza, este tipo de realidade. Optou-se pela leitura de quatro traduções, em línguas latinas, de três passagens do Livro V – ‘Edifícios para fins particulares’: a tradução de Giovanni Orlandi, a de Javier Fresnillo Núñez, a de Pierre Caye e Françoise Choay, bem como a de Arnaldo Espírito Santo e Mário Krüger. O tipo de “monte” que pretendo investigar, corresponde a uma arquitectura aparentemente anónima, mas que tem na sua génese um pensamento arquitectónico. Um dos ‘rastos escritos’ que possui, foi encontrado no tratado de Alberti, dando-lhe a ‘voz teórica’ que lhe falta, para lhe permitir ‘dizer aquilo que não é capaz’. EN Note the title: the term “montes” is in inverted commas due to the difficulty in finding an own designation that allows characterizing the study object of the PhD Research. This difficulty arises by the existence of three distinct realities in the ‘alentejano’ context: ‘quinta’, ‘monte’ and ‘herdade’. In order to find a name to title this architectural reality, we resorted to the translation, as a research process itself: the classical treatises were called to inform the contemporary one. In this way, we realized that it would be appropriate to study the treaty ‘De Re Ædificatoria’ of Leon Battista Alberti, once characterizes this type of reality. We decided reading four translations from three passages of the Book V – “Buildings for private purposes”, in Latin languages that are the translation of Giovanni Orlandi, of Javier Fresnillo Núñez, of Pierre Caye and Françoise Choay, and of Arnaldo Espírito Santo and Mário Krüger. The type of “monte” that we intend to investigate, corresponds to an apparently anonymous architecture, but that has in its genesis an architectural thinking. One of its ‘written tracks’ has been found in Alberti’s treatise, given the theoretical voice that lacks, in order to allow it ‘to say what can not’.
7. Bremer eBook-Tag
Authors: Rauchmann Sabine 
Published: October 2015

Zusammenfassung:
Seit 2006 richtet der Bibliotheksdienstleister Missing Link den Bremer eBook-Tag aus. Auf der diesjährigen Veranstaltung stellten Bibliothekare, Verlagsvertreter und Buchhändler ihre Erfahrungen mit der nutzergestützten (EBS) und der nutzergesteuerten (PDA) Erwerbung von E-Books vor. Weiterhin präsentierten drei Verlage ihre E-Book-Strategie. Der vorliegende Beitrag bietet einen Überblick über die Veranstaltung und fasst die Vorträge zusammen.
Two letters by Brutus and Cassius to Mark Antony: different people, different times, different styles
Authors: Calboli Gualtiero 
Published: October 2015

AbstractBetween end of May and beginning of August 44 M. Junius Brutus, praetor urbanus, and C. Cassius Longinus, praetor peregrinus, sent two letters to M. Antony who was consul. These letters were different in content and style but also the two senders were different. If we take into account the facts of this time we see that the situation in Rome changed and M. Antony gave up his previous position (assumed 17 March 44), which was oriented towards the
First Principles Study of Electronic Structure, Magnetic, and Mechanical Properties of Transition Metal Monoxides TMO(TM=Co and Ni)
Authors: Cinthia Arumainayagam Jemmy , Rajeswarapalanichamy Ratnavelu , Iyakutti Kombiah 
Published: October 2015

Abstract
The ground-state properties, electronic structure, magnetic and mechanical properties of cobalt oxide (CoO) and nickel oxide (NiO) are investigated using generalised gradient approximation parameterised by Perdew–Burke–Ernzerhof (GGA-PBE) and GGA-PBE+U formalisms. These oxides are found to be stable in the antiferromagnetic (AFM) state at normal pressure. The computed lattice parameters are in agreement with the experimental and other theoretical works. Pressure-induced magnetic transition from AFM to ferromagnetic (FM) state is predicted in NiO at a pressure of 84 GPa. Both these compounds are found to be mechanically stable in the AFM state at normal pressure.
The end of the affair: formal chronological modelling for the top of the Neolithic tell of Vinča-Belo Brdo
Authors: Tasić Nenad , Marić Miroslav , Penezić Kristina , Filipović Dragana , Borojević Ksenija , Russell Nicola , Reimer Paula , Barclay Alistair , Bayliss Alex , Borić Dušan , Gaydarska Bisserka , Whittle Alasdair 
Published: October 2015

Abstract
Estimation of Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data
Authors: Lopes Marcos S , Bastiaansen John W M , Janss Luc , Knol Egbert F , Bovenhuis Henk 
Published: October 2015

Abstract
Traditionally, exploration of genetic variance in humans, plants, and livestock species has been limited mostly to the use of additive effects estimated using pedigree data. However, with the development of dense panels of single-nucleotide polymorphisms (SNPs), the exploration of genetic variation of complex traits is moving from quantifying the resemblance between family members to the dissection of genetic variation at individual loci. With SNPs, we were able to quantify the contribution of additive, dominance, and imprinting variance to the total genetic variance by using a SNP regression method. The method was validated in simulated data and applied to three traits (number of teats, backfat, and lifetime daily gain) in three purebred pig populations. In simulated data, the estimates of additive, dominance, and imprinting variance were very close to the simulated values. In real data, dominance effects account for a substantial proportion of the total genetic variance (up to 44%) for these traits in these populations. The contribution of imprinting to the total phenotypic variance of the evaluated traits was relatively small (1–3%). Our results indicate a strong relationship between additive variance explained per chromosome and chromosome length, which has been described previously for other traits in other species. We also show that a similar linear relationship exists for dominance and imprinting variance. These novel results improve our understanding of the genetic architecture of the evaluated traits and shows promise to apply the SNP regression method to other traits and species, including human diseases.
Estimating Trait Heritability in Highly Fecund Species
Authors: Davies Sarah W , Scarpino Samuel V , Pongwarin Thanapat , Scott James , Matz Mikhail V 
Published: October 2015

Abstract
Increasingly, researchers are interested in estimating the heritability of traits for nonmodel organisms. However, estimating the heritability of these traits presents both experimental and statistical challenges, which typically arise from logistical difficulties associated with rearing large numbers of families independently in the field, a lack of known pedigree, the need to account for group or batch effects, etc. Here we develop both an empirical and computational methodology for estimating the narrow-sense heritability of traits for highly fecund species. Our experimental approach controls for undesirable culturing effects while minimizing culture numbers, increasing feasibility in the field. Our statistical approach accounts for known issues with model-selection by using a permutation test to calculate significance values and includes both fitting and power calculation methods. We further demonstrate that even with moderately high sample-sizes, the p-values derived from asymptotic properties of the likelihood ratio test are overly conservative, thus reducing statistical power. We illustrate our methodology by estimating the narrow-sense heritability for larval settlement, a key life-history trait, in the reef-building coral Orbicella faveolata. The experimental, statistical, and computational methods, along with all of the data from this study, are available in the R package multiDimBio.
A Nonsense Variant in COL6A1 in Landseer Dogs with Muscular Dystrophy
Authors: Steffen Frank , Bilzer Thomas , Brands Jan , Golini Lorenzo , Jagannathan Vidhya , Wiedmer Michaela , Drögemüller Michaela , Drögemüller Cord , Leeb Tosso 
Published: October 2015

Abstract
A novel canine muscular dystrophy in Landseer dogs was observed. We had access to five affected dogs from two litters. The clinical signs started at a few weeks of age, and the severe progressive muscle weakness led to euthanasia between 5 and 15 months of age. The pedigrees of the affected dogs suggested a monogenic autosomal-recessive inheritance of the trait. Linkage and homozygosity mapping indicated two potential genome segments for the causative variant on chromosomes 10 and 31 harboring a total of 4.8 Mb of DNA or 0.2% of the canine genome. Using the Illumina sequencing technology, we obtained a whole-genome sequence from one affected Landseer. Variants were called with respect to the dog reference genome and compared with the genetic variants of 170 control dogs from other breeds. The affected Landseer dog was homozygous for a single, private nonsynonymous variant in the critical intervals, a nonsense variant in the COL6A1 gene (Chr31:39,303,964G&gt;T; COL6A1:c.289G&gt;T; p.E97*). Genotypes at this variant showed perfect concordance with the muscular dystrophy phenotype in all five cases and more than 1000 control dogs. Variants in the human COL6A1 gene cause Bethlem myopathy or Ullrich congenital muscular dystrophy. We therefore conclude that the identified canine COL6A1 variant is most likely causative for the observed muscular dystrophy in Landseer dogs. On the basis of the nature of the genetic variant in Landseer dogs and their severe clinical phenotype these dogs represent a model for human Ullrich congenital muscular dystrophy.
A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas
Authors: Munhoz Rodrigo R. , D'Angelo Sandra P. , Gounder Mrinal M. , Keohan Mary L. , Chi Ping , Carvajal Richard D. , Singer Samuel , Crago Aimee M. , Landa Jonathan , Healey John H. , Qin Li-Xuan , Hameed Meera , Ezeoke Marietta O. , Singh Arun S. , Agulnik Mark , Chmielowski Bartosz , Luke Jason J. , Van Tine Brian A. , Schwartz Gary K. , Tap William D. , Dickson Mark A. 
Published: October 2015

Abstract

Author Summary

Lessons Learned
Our results highlight some of the challenges in the management of soft tissue sarcomas, which requires close cooperation between surgeons and medical oncologists and a careful selection of patients. The incidence of hepatotoxicity was a concerning finding and had been previously reported in patients treated with pazopanib. Although pharmacokinetic analysis was not part of this study, concomitant treatment with pazopanib has been recently reported to increase docetaxel exposure, which may explain the increased toxicity of combination regimens. It remains possible that lower doses of combined gemcitabine, docetaxel, and pazopanib may be tolerable. However, caution should be exercised in future trials investigating similar combinations.

Background.
For extremity soft tissue sarcomas (STS), surgical resection remains the standard of care, and the addition of chemotherapy is controversial. This was a phase Ib/II trial of neoadjuvant therapy for patients with STS.

Methods.
Patients with high grade, extremity STS of &gt;8 cm and amenable to definitive resection were treated with up to four 21-day cycles of 900 mg/m2 gemcitabine on days 1 and 8, 75 mg/m2 docetaxel on day 8, and 400 mg of pazopanib daily (GDP), followed by surgery and, if indicated, radiation therapy. Primary and secondary endpoints (phase Ib portion) were the safety and rate of pathologic response.

Results.
The trial was discontinued because of slow accrual after inclusion of five patients (leiomyosarcoma: two; undifferentiated pleomorphic sarcoma: three). Two patients completed four treatment cycles: one underwent surgery and one had insufficient response and received additional therapies. Three patients discontinued treatment because of toxicity. Grade 3 adverse events included hypertension, fatigue, aspartate aminotransferase (AST) or alanine aminotransferase (ALT) elevation, hoarseness, and myelotoxicity. There were no complete or partial responses. One patient had ≥90% pathologic response. Among four patients who underwent resection, three remain free of disease, and one patient eventually relapsed.

Conclusion.
GDP combination used in the neoadjuvant setting resulted in significant toxicity; despite pathologic responses, no objective responses occurred.
What is Successful Islet Transplantation in 2006?
Authors: Robertson R Paul 
Published: October 2015

Pre-Edmonton Era—The PastDuring the past six years, transplant teams have been intensely focused on improving the rather dismal history of pancreatic islet allograft transplantation in humans. This short review will consider the status of islet transplantation in 2006 in the context both of success rates of islet transplantation prior to 2000 and current success with whole pancreas transplantation.Successful clinical pancreas transplantation for type 1 diabetes was first reported by the University of Minnesota in 1966 (see Figure 1). In the ensuing years, operative techniques and immunosuppressive drug regimens improved significantly.
Beta-cell Defects in Type 2 Diabetes and the Possibility of Treatment Options with GLP-1-based Therapies
Authors: Gallwitz Baptist 
Published: October 2015

Type 2 Diabetes as a Progressive DiseaseIn type 2 diabetes, beta-cell dysfunction plays a major part not only in the pathogenesis of the disease, but also in disease progression over time. Under normal conditions, blood glucose concentrations are regulated within a very tight range. After a meal, insulin secretion from the beta cell is stimulated, whereas glucagon secretion from the alpha cells is suppressed. Insulin facilitates glucose uptake into the cells, whereas glucagon stimulates glucose production in the liver.
Correlation Between Visfatin, Insulin Resistance (Homeostasis Model Assesment of Insulin Resistance), Inflammation (High Sensitivity C-Reactive Protein) and HDL Cholesterol Concentration in Individuals with Visceral Obesity
Authors: Budiyati Rini , Lukito Widjaja , Wijaya Andi 
Published: October 2015

BACKGROUND: Visfatin is a novel adipokine secreted from visceral adipose tissue and has insulinomimetic properties. Visceral obesity is a risk factor for metabolic syndrome. Insulin resistance and inflammation are linked to visceral obesity and metabolic syndrome. Dysregulation of visfatin as an adipokine could play an important role in metabolic syndrome through insulin resistance and inflammation, or lower HDL cholesterol concentration. However, this need more evidence.METHOD: This was a crossectional study in 40 Indonesian obese men and 40 Indonesian obese women. Age: 30-60 years in men and 50-60 years for women, from February to March 2008 in Jakarta.RESULTS: No correlation between visfatin and hs-CRP as a marker of inflammation (r=0.190, p=0,101), or HOMA-IR as a marker of insulin resistance (r=-0.020, p=0.246). Suprisingly visfatin concentration is correlated with HDL Cholesterol (r=0.416, p=0.000).CONCLUSIONS: Visfatin plays an important role in metabolic syndrome through lipid metabolism. Positive correlation between visfatin and HDL cholesterol, was assumed that visfatin had a protective effect. Visfatin also known as as nicotinamide phosphoribosyltransferase (NAMPT) links Nicotinamide Adenine Dinucleotide (NAD) metabolism and raising of HDL Cholesterol. But the exact mechanisms need to be further studied.KEYWORDS: visceral obesity, metabolic syndrome, NAMPT, visfatin, HDL
Estimating Serving Sizes for Healthier and Unhealthier Versions of Food According to Canada’s Food Guide
Authors: Parikh Sina , Hamadeh Mazen J. , Kuk Jennifer L. 
Published: October 2015

Purpose: Canada’s Food Guide (CFG) defines food serving sizes and recommends a specific number of servings from each of the 4 food groups. However, there is no differentiation in serving sizes for different versions of foods that may differ in nutritional value.Methods: Participants (n = 20) estimated serving sizes of “healthier” and “unhealthier” versions of milk, bread, cereal, potatoes, chicken, fish, and juice and reported the amount normally consumed in 1 sitting.Results: Participants estimated unhealthier servings of cereal and juice to be smaller than healthier servings, but estimated unhealthier servings of chicken to be larger than healthier versions (P < 0.05). There were no differences for bread, milk, potatoes, and fish. Accordingly, estimated servings of juice (P < 0.01) had more calories than the unhealthier orange drink. There were no caloric differences for cereal (P = 0.12), but an estimated serving of bran flakes had more fat and fibre than frosted flakes cereal.Conclusions: In contrast with CFG, which does not account for different versions of food, certain unhealthier foods were estimated to be smaller or larger than the healthier versions. However, both healthy and unhealthy serving sizes still tended to be larger than what is prescribed in CFG. Thus, better education or revision of serving sizes in future editions of CFG may warrant consideration.
Development and Initial Reliability Testing of NAK-50+: A Nutrition Attitude and Knowledge Questionnaire for Adults 50+ Years of Age
Authors: Ducak Kate , Keller Heather 
Published: October 2015

Purpose: Few questionnaires to test nutrition knowledge and attitudes of older adults living independently in the community have been developed and tested to assess self-management tools such as Nutri-eSCREEN and other education programs. This study is a first step in the development of a questionnaire designed to evaluate the nutrition knowledge and attitudes of independent older adults (NAK-50+).Methods: The steps involved in this study were: (i) drafting initial questions based on the content of the Nutri-eSCREEN education material, (ii) using cognitive interviewing to determine if these questions were understandable and relevant (n = 9 adults ≥50 years of age), and (iii) completing test–retest reliability in a convenient community sample (n = 60 adults ≥50 years of age). Intra-class coefficients (ICC) and kappa were used to determine reliability.Results: A 33-item questionnaire resulted from this development and analysis. ICC for the total score was 0.68 indicating good agreement and thus initial reliability.Conclusions: NAK-50+ is a face valid and reliable questionnaire that assesses nutrition knowledge and attitudes in independent adults aged ≥50 years. Further work to determine construct validity and to refine the questionnaire is warranted. Availability of the questionnaire for this age group will support rigorous evaluation of education and self-management interventions for this segment of the population.