bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary Study on the Relation between the Coping Patterns and Mental Health of Radiation Control Personnel and Nondestructive Inspectors Engaged in the Periodic Inspections of Nuclear Power Plants
Authors: Nagaoka Chika , Uchida Yukiko 
Published: April 2014

Preliminary Study on the Relation between the Coping Patterns and Mental Health of Radiation Control Personnel and Nondestructive Inspectors Engaged in the Periodic Inspections of Nuclear Power Plants: Chika NAGAOKA, et al. Department of Management, Otemon Gakuin University—ObjectiveIn order to safely manage nuclear power plants, their workforce should be mentally healthy. This study clarifies the coping strategies of radiation control personnel and nondestructive inspectors engaged in the periodic inspection of nuclear power plants, the effect of the coping strategies on their mental health, as well as any effect based on whether or not they had worked after the nuclear disaster caused by the Great East Japan Earthquake and tsunami in March 2011.MethodsA questionnaire survey was administered to 133 technicians attending a certification course, and among them, our subjects of analysis were 104 people with work experience in radiation control and/or nondestructive inspection.ResultsThe results indicated that even among workers of the same company who were assigned to similar duties in the periodic inspections of nuclear power plants, the group that had worked at a nuclear plant after the disaster had a tendency to use coping strategies, such as giving up and avoidancelike thinking, which was dissimilar to the group that had not worked at a nuclear plant after the disaster. Further, the former group had higher levels of distress than those who tended to use other coping strategies. In addition, the results suggested that the plan‐drafting strategy adopted by the group that had not worked after the disaster did not result in stress reduction.DiscussionBased on these results, we propose a stress management program specifically for radiation workers.
Photoluminescence Characterization of Phosphorus Diffusion and Hydrogenation in Continuous Wave Diode Laser Crystallized Si Thin-Film on Glass.
Authors: Jung Miga , Teal Anthony , Evans Rhett , Yun Jae Sung , Varlamov Sergey , Green Martin A. 
Published: April 2014

ABSTRACTIn this paper, the effect of phosphorus diffusion and hydrogen passivation on the material properties of laser crystallised silicon on glass is investigated. Photoluminescence imaging, as well as Hall effect and Suns-Voc techniques are applied for the characterisation of laser crystallized silicon thin-film material properties. Hall effect as well as Suns-Voc measurements supports the photoluminescence imaging results; phosphorus diffusion and hydrogen passivation of laser crystallized films improves the overall material quality. Hydrogen passivation is more effective at improving the electronic properties of the laser crystallized films than phosphorus diffusion. Hydrogen passivated samples improved the photoluminescence intensity even further by a factor of 3. In addition, a correlation between photoluminescence intensity and open-circuit voltage is demonstrated: samples with highest photoluminescence intensity (1678 counts/s), gave the highest voltage (530 mV). Hall effect measurement shows a significant improvement in the bulk material, with carrier mobility increasing from 208 cm2/Vs to 488 cm2/Vs.
A Critical Review of Nuisance Foam Formation and Biological Methods for Foam Management or Elimination in Nutrient Removal Facilities
Authors: Parker Denny , Bratby John , Esping Don , Hull Ted , Kelly Rick , Melcer Henryk , Merlo Rion , Pope Rod , Shafer Todd , Wahlberg Eric , Witzgall Robert 
Published: April 2014

ABSTRACT: The classifying selector was introduced to the wastewater industry in 2001, after several successful full‐scale applications. The classifying selector concept distinguishes itself from the earlier surface foam wasting schemes in that negative selection pressure is maintained so that nuisance foam‐causing organisms cannot gain a foothold in sufficient numbers to cause nuisance foams. The propensity of the nuisance‐causing organism to attach to bubbles and establish a rising velocity is used to enrich them in a surface mixed liquor layer, where they are wasted. Neither standard texts nor the Water Environment Federation's Manuals of Practice adequately describe this, and as a result, the benefits of foam elimination obtainable through use of the classifying selector concepts have not been broadly obtained in our industry. In certain types of processes that are inherently foam trapping situations, the only solution is surface foam wasting, as foam cannot be eliminated. Potential efficiency gains possible in these situations are addressed.
Osteosarcoma following tibial plateau leveling osteotomy in dogs: 29 cases (1997–2011)
Authors: Selmic Laura E. , Ryan Stewart D. , Boston Sarah E. , Liptak Julius M. , Culp William T. N. , Sartor Angela J. , Prpich Cassandra Y. , Withrow Stephen J. 
Published: April 2014

Abstract
Objective—To determine the signalment, tibial plateau leveling osteotomy (TPLO) plate type, clinical staging information, treatment, and oncological outcome in dogs that developed osteosarcoma at the proximal aspect of the tibia following TPLO and to calculate the interval between TPLO and osteosarcoma diagnosis.
Design—Multi-institutional retrospective case series.
Animals—29 dogs.
Procedures—Medical records from 8 participating institutions were searched for dogs that developed osteosarcoma (confirmed through cytologic or histologic evaluation) at previous TPLO sites. Signalment, TPLO details, staging tests, treatment data, and outcome information were recorded. Descriptive statistics were calculated, and disease-free intervals and survival times were evaluated by means of Kaplan-Meier analysis.
Results—29 dogs met the inclusion criteria. The mean age was 9.2 years and mean weight was 45.1 kg (99.2 lb) at the time of osteosarcoma diagnosis. Most dogs had swelling over the proximal aspect of the tibia (17/21) and lameness of the affected limb (28/29). The mean interval between TPLO and osteosarcoma diagnosis was 5.3 years. One type of cast stainless steel TPLO plate was used in most (18) dogs; the remaining dogs had received plates of wrought stainless steel (n = 4) or unrecorded type (7). Twenty-three of 29 dogs underwent treatment for osteosarcoma. Median survival time for 10 dogs that underwent amputation of the affected limb and received ≥ 1 chemotherapeutic treatment was 313 days.
Conclusions and Clinical Relevance—Results supported that osteosarcoma should be a differential diagnosis for dogs with a history of TPLO that later develop lameness and swelling at the previous surgical site. Oncological outcome following amputation and chemotherapy appeared to be similar to outcomes previously reported for dogs with appendicular osteosarcoma.
A cohomological index of Fuller type for parameterized set-valued maps in normed spaces
Authors: Skiba Robert 
Published: April 2014

Abstract
We construct a cohomological index of the Fuller type for set-valued flows in normed linear spaces satisfying the properties of existence, excision, additivity, homotopy and topological invariance. In particular, the constructed index detects periodic orbits and stationary points of set-valued dynamical systems, i.e., those generated by differential inclusions. The basic methods to calculate the index are also presented.
Statistical Large-Break LOCA analysis for PWRs with combined ECC injection
Authors: Seeberger G.-J. , Pauli E.-M. , Trewin R. , Zeisler L.-P. 
Published: April 2014

Abstract
A statistical analysis methodology based on the code scaling, applicability and uncertainty (CSAU) evaluation approach for predicting the safety margin in case of a postulated large-break loss-of-coolant accident (LBLOCA) in a pressurized-water reactor (PWR) was developed by AREVA. All expected LBLOCA phenomena are listed in the Phenomena Identification and Ranking Table (PIRT) and are prioritized according to their importance on the figure of merit, here the fuel rod peak cladding temperature (PCT). For the high-ranked phenomena parameters are identified, which allow a quantification of the analysis uncertainty. AREVA has updated the PIRT to the state of the art and extended it to the application to pressurized-water reactors with combined emergency core cooling injection of German-type PWRs. This paper describes how the uncertainty distributions, required for a statistical analysis, have been derived and presents the result of an exemplary statistical analysis for a German-type 4-loop plant compared to that of a conservative deterministic analysis.
Explicit formulation of a nodal transport method for discrete ordinates calculations in two-dimensional fixed-source problems
Authors: Tres A. , Picoloto C. B. , Filho J. F. Prolo , da Cunha R. D. , Barichello L. B. 
Published: April 2014

Abstract
In this work a study of two-dimensional fixed-source neutron transport problems, in Cartesian geometry, is reported. The approach reduces the complexity of the multidimensional problem using a combination of nodal schemes and the Analytical Discrete Ordinates Method (ADO). The unknown leakage terms on the boundaries that appear from the use of the derivation of the nodal scheme are incorporated to the problem source term, such as to couple the one-dimensional integrated solutions, made explicit in terms of the x and y spatial variables. The formulation leads to a considerable reduction of the order of the associated eigenvalue problems when combined with the usual symmetric quadratures, thereby providing solutions that have a higher degree of computational efficiency. Reflective-type boundary conditions are introduced to represent the domain on a simpler form than that previously considered in connection with the ADO method. Numerical results obtained with the technique are provided and compared to those present in the literature.
Platelet-mediated changes to neuronal glutamate receptor expression at sites of microthrombosis following experimental subarachnoid hemorrhage
Authors: Bell Joshua D. , Thomas Theresa Currier , Lass Elliot , Ai Jinglu , Wan Hoyee , Lifshitz Jonathan , Baker Andrew J. , Macdonald R. Loch 
Published: April 2014

Object
Glutamate is important in the pathogenesis of brain damage after cerebral ischemia and traumatic brain injury. Notably, brain extracellular and cerebrospinal fluid as well as blood glutamate concentrations increase after experimental and clinical trauma. While neurons are one potential source of glutamate, platelets also release glutamate as part of their recruitment and might mediate neuronal damage. This study investigates the hypothesis that platelet microthrombi release glutamate that mediates excitotoxic brain injury and neuron dysfunction after subarachnoid hemorrhage (SAH).

Methods
The authors used two models, primary neuronal cultures exposed to activated platelets, as well as a whole-animal SAH preparation. Propidium iodide was used to evaluate neuronal viability, and surface glutamate receptor staining was used to evaluate the phenotype of platelet-exposed neurons.

Results
The authors demonstrate that thrombin-activated platelet-rich plasma releases glutamate, at concentrations that can exceed 300 μM. When applied to neuronal cultures, this activated plasma is neurotoxic, and the toxicity is attenuated in part by glutamate receptor antagonists. The authors also demonstrate that exposure to thrombin-activated platelets induces marked downregulation of the surface glutamate receptor glutamate receptor 2, a marker of excitotoxicity exposure and a possible mechanism of neuronal dysfunction. Linear regression demonstrated that 7 days after SAH in rats there was a strong correlation between proximity to microthrombi and reduction of surface glutamate receptors.

Conclusions
The authors conclude that platelet-mediated microthrombosis contributes to neuronal glutamate receptor dysfunction and might mediate brain injury after SAH.
Changes in Biomarkers in HIV-1-Infected Treatment-Naive Patients Treated with Tenofovir DF/Emtricitabine plus Atazanavir/Ritonavir or Lopinavir/Ritonavir for 96 Weeks: The CASTLE Biomarker Substudy
Authors: Moyle Graeme , Hardy Helene , Uy Jonathan , Ray Neelanjana , Jimenez-Exposito Maria Jesus , McGrath Donnie , DeJesus Edwin 
Published: April 2014

Background The impact of boosted protease inhibitor therapy on inflammatory and cardiovascular biomarker levels in treatment-naive HIV-infected patients remains unclear and may differ between agents. Unconjugated bilirubin elevation, which favourably affects vascular biomarkers and cardiovascular disease risk in Gilbert's syndrome, occurs with atazanavir. Methods CASTLE was a 96-week study comparing efficacy and safety in treatment-naive HIV-1-infected patients randomized to atazanavir/ritonavir (ATV/r) versus lopinavir/ritonavir (LPV/r), each in combination with tenofovir disoproxil fumarate/emtricitabine. In this substudy, fasting plasma tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), high sensitivity C-reactive protein (hs-CRP), plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were assessed at baseline, week 12, 24, 48 and 96. Impact of grade 3–4 hyperbilirubinaemia on biomarkers was examined. Results CASTLE demonstrated similar efficacy in both treatment arms with higher rates of hyperbilirubinaemia on ATV/r and elevated lipids on LPV/r. In this substudy ( n=224), patterns of biomarker expression were similar between the ATV/r and LPV/r groups and between-group differences in biomarker percentage change from baseline were not significant at 48 and/or 96 weeks. Hyperbilirubinaemia did not influence fasting biomarker expression. Conclusions No significant differences were noted between ATV/r and LPV/r for biomarker percentage changes from baseline. Furthermore, no association was found between total bilirubin levels and biomarker expression.
La jouissance négativement phallique. De la belle Bouchère au rêve du cochon
Authors: Blaquière Hélène 
Published: April 2014

De quoi l’hystérique jouit-elle ? L’exploration de l’insatisfaction permet de mettre au jour un mode de jouissance spécifique, ni tout à fait réduit à une jouissance phallique, ni véritablement distinct. L’hystérique se tient sur ce bord, en maintenant son désir insatisfait. L’accès à une jouissance féminine, telle est notre hypothèse, repose sur l’assomption du fantasme incestueux. Ainsi seulement, pourrait-on accéder à une jouissance Autre.
Les leçons cliniques de Socrate
Authors: Zafiropoulos Markos 
Published: April 2014

Cet article vise à montrer comment et en quoi la lecture de Lacan du Banquet de Platon constitue aujourd’hui la leçon inaugurale de la clinique de l’hystérie masculine et pourquoi Lacan a fait de ce texte et donc de l’amour homosexuel au masculin la référence centrale de sa recherche sur l’éminente question du transfert pour son séminaire éponyme de 1960- 1961.
Cutting Edge: Dominance by an MHC-Independent Inhibitory Receptor Compromises NK Killing of Complex Targets
Authors: Wahle Joseph A. , Paraiso Kim H. T. , Costello Amy L. , Goll Emily L. , Sentman Charles L. , Kerr William G. 
Published: April 2014

Abstract
Inhibitory receptors that recognize MHC class I molecules regulate NK cell responses and self-tolerance. Recent evidence indicates that self-ligands not present in the MHC locus also can modulate NK function. In this study, we show that an inhibitory receptor that recognizes an MHC-independent ligand is over expressed in SHIP−/− mice at all stages of NK development and differentiation. Overexpression of this receptor compromises key cytolytic NK functions, including killing of allogeneic, tumor, and viral targets. These results further demonstrate the critical role that SHIP plays in regulation of the NK receptor repertoire and show that regulation of MHC-independent inhibitory receptors is crucial for NK recognition and cytolysis of complex targets.
Biliary Obstruction Selectively Expands and Activates Liver Myeloid Dendritic Cells
Authors: Bleier Joshua I. , Katz Steven C. , Chaudhry Umer I. , Pillarisetty Venu G. , Kingham T. Peter , Shah Alaap B. , Raab Jesse R. , DeMatteo Ronald P. 
Published: April 2014

Abstract
Obstructive jaundice is associated with immunologic derangements and hepatic inflammation and fibrosis. Because dendritic cells (DCs) play a major role in immune regulation, we hypothesized that the immunosuppression associated with jaundice may result from the functional impairment of liver DCs. We found that bile duct ligation (BDL) in mice expanded the myeloid subtype of liver DCs from 20 to 80% of total DCs and increased their absolute number by &gt;15-fold. Liver myeloid DCs following BDL, but not sham laparotomy, had increased Ag uptake in vivo, high IL-6 secretion in response to LPS, and enhanced ability to activate T cells. The effects of BDL were specific to liver DCs, as spleen DCs were not affected. Expansion of liver myeloid DCs depended on Gr-1+ cells, and we implicated monocyte chemotactic protein-1 as a potential mediator. Thus, obstructive jaundice selectively expands liver myeloid DCs that are highly functional and unlikely to be involved with impaired host immune responses.
In Situ Replication of Immediate Dendritic Cell (DC) Precursors Contributes to Conventional DC Homeostasis in Lymphoid Tissue
Authors: Diao Jun , Winter Erin , Cantin Claude , Chen Wenhao , Xu Luoling , Kelvin David , Phillips James , Cattral Mark S. 
Published: April 2014

AbstractThe developmental biology of dendritic cells (DC) under physiological conditions remains unclear. In this study, we show that mouse CD11c+ MHC class II−lineage− cells are immediate precursors of conventional DC and are widely distributed in both bone marrow and lymphoid tissues. These precursors have a high clonal efficiency, and when cocultured on a supportive stromal monolayer or adoptively transferred in vivo, generate a population CD11c+MHC class II+ DC that retain limited proliferation capacity. During steady state conditions, a small proportion of immediate DC precursors (DCp) and DCs are dividing actively in bone marrow and spleen. Cytokines that initiate and support proliferation of immediate DCp were defined. Collectively, our findings provide evidence of a distinct development pathway for conventional DC in both bone marrow and lymphoid tissues and highlight the importance of in situ replication of immediate DCp and DC in maintaining conventional DC populations.
Tyk2 Negatively Regulates Adaptive Th1 Immunity by Mediating IL-10 Signaling and Promoting IFN-γ-Dependent IL-10 Reactivation
Authors: Shaw Michael H. , Freeman Gordon J. , Scott Mark F. , Fox Barbara A. , Bzik David J. , Belkaid Yasmine , Yap George S. 
Published: April 2014

AbstractThe Jak, Tyk2, is activated in response to IL-12 and IFN-αβ and promotes IFN-γ production by Th1-type CD4 cells. Mice deficient in Tyk2 function have been previously shown to be resistant to autoimmune arthritis and septic shock but are acutely susceptible to opportunistic pathogens such as Toxoplasma gondii. In this study, we show that Tyk2, in addition to mediating the biological effects of IL-12 and IFN-αβ, is an important regulator for the signaling and expression of the immunosuppressive cytokine IL-10. In the absence of Tyk2, Ag-reactive CD4 cells exhibit impaired IL-10 synthesis following rechallenge of T. gondii vaccine-primed mice. The impaired IL-10 reactivation leads to unopposed antimicrobial effector mechanisms which results in a paradoxically superior protection of immune Tyk2−/− mice against virulent T. gondii challenge. We further demonstrate that Tyk2 indirectly controls CD4 IL-10 reactivation by signaling for maximal IFN-γ secretion. The unexpected role of IFN-γ in mediating IL-10 reactivation by Th1 cells provides compelling evidence that conditions driving Th1 responses establish a negative feedback loop, which will ultimately lead to its autoregulation. Thus, Tyk2 can be viewed as a dual-function Jak, mediating both pro and anti-inflammatory cytokine responses.
The Sialyltransferase ST3Gal-I Is Not Required for Regulation of CD8-Class I MHC Binding during T Cell Development
Authors: Kao Charlly , Sandau Michelle M. , Daniels Mark A. , Jameson Stephen C. 
Published: April 2014

AbstractThe CD8 coreceptor plays a crucial role in thymocyte and T cell sensitivity by binding to class I MHC and recruiting downstream signaling molecules to the TCR. Previous studies reported considerable changes in TCR-independent CD8/class I MHC binding (i.e., CD8 noncognate interactions) during T cell development, changes that correlated with altered glycosylation of surface molecules. In particular, expression of the sialyltransferase ST3Gal-I has been proposed as a critical factor regulating the attenuation of CD8 avidity during the double-positive to CD8 single-positive progression. This hypothesis is strengthened by the fact that ST3Gal-I−/− animals show a profound disregulation of CD8 T cell homeostasis. In contrast to this model, however, we report in this study that ST3Gal-I deficiency had no detectable impact on CD8 noncognate binding to multimeric peptide/MHC class I ligands at any stage of thymocyte development. We also found that the susceptibility to CD8-induced cell death is not markedly influenced by ST3Gal-I deficiency. Thus, the profound effects of ST3Gal-I on CD8 T cell survival evidently do not involve a role for this enzyme in controlling CD8-class I binding.
Diesel Exhaust Particle-Exposed Human Bronchial Epithelial Cells Induce Dendritic Cell Maturation
Authors: Bleck Bertram , Tse Doris B. , Jaspers Ilona , Curotto de Lafaille Maria A. , Reibman Joan 
Published: April 2014

Abstract
Increased exposure to air pollutants such as diesel exhaust particles (DEP) has been proposed as one mechanism to explain the rise in allergic disorders. However, the immunologic mechanisms by which DEP enhance allergic sensitization and asthma remain unclear. We hypothesized that DEP act as an adjuvant for immature dendritic cell (DC) maturation via its effect on airway epithelial cell-derived microenvironment for DC. Immature monocyte-derived DC (iMDDC) failed to undergo phenotypic (CD80, CD83, CD86) or functional (T cell activation) maturation in response to exposure to DEP (0.001–100 μg/ml). In contrast, primary cultures of human bronchial epithelial cells (HBEC) treated with DEP induced iMDDC phenotypic maturation (2.6 ± 0.1-fold increase in CD83 expression, n = 4, p &lt; 0.05) and functional maturation (2.6 ± 0.2-fold increase in T cell activation, n = 4, p &lt; 0.05). Functional maturation of iMDDC was induced by conditioned medium derived from DEP-treated HBEC, and was inhibited in cultures with DEP-treated HBEC and blocking Abs against GM-CSF, or GM-CSF-targeted small interfering RNA. These data suggest that DEP induce Ag-independent DC maturation via epithelial cell-DC interactions mediated by HBEC-derived GM-CSF. Although additional signals may be required for polarization of DC, these data suggest a novel mechanism by which environmental pollutants alter airway immune responses.