bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beetle assemblage distribution along edge–forest gradient in a managed oak forest
Authors: Balázs Attila , Bezděk Jan , Šipoš Jan 
Published: July 2024

Abstract
Forest management practices creating small‐scale forest edge habitats in managed forests have substantial impacts on the formation of beetle assemblages.
In 2021, we conducted research in a managed oak woodland in Central Slovakia using three flight interception traps (FITs) to study beetle assemblages. Two FITs were installed at the forest edge, facing both, the clearing and the closed‐stand forest, while the third FIT was positioned 100 m within the closed‐canopy forest. We employed a novel methodological approach, which involved separately collected subsamples within the ecotone using FITs differentiated as ‘ecotone inwards’ and ‘ecotone outwards’ to capture distinct directional movements at the edge.
We recorded 5.997 beetle specimens, encompassing 417 species across 284 genera and 58 families. We found that the species diversity and abundance of beetles were not significantly different between the FITs. However, the species composition was significantly different.
The partial detrended canonical correspondence analysis suggests that these compositional differences might be closely associated with the distribution of trophic guilds, indicating varied responses to habitat modifications induced by forest edge creation. The results of our study showed that phloephagous, saproxylophagous, xylomycetophagous, xylophagous and zoophagous beetles exhibited a positive association with the forest edge, while mycophagous, phytophagous and saprophagous groups were distinctly associated with the closed‐canopy forest.
Our analyses indicated that the ‘ecotone outward’ part of forest edges of managed forest may attract higher number of trophic groups, while the ‘ecotone inward’ part of the forest edge hosted high abundances of phloephagous and xylomycetophagous species.
Characterization of omalizumab updosing patterns and predictive factors in chronic spontaneous urticaria: A prospective multicentric observational study
Authors: Pierrard Guillaume , Bernier Claire , Du‐Thanh Aurélie , Bara Corina , Soria Angèle , Castelain Florence , Boccon‐Gibod Isabelle , Hacard Florence , Delaunay Juliette , de Montjoye Laurence , Staumont‐Salle Delphine , Dezoteux Frédéric 
Published: July 2024

AbstractBackgroundLimited information is available on the use of omalizumab (OMA) updosing since its introduction as a second‐line therapy in chronic spontaneous urticaria (CSU) in 2014. Practical guidelines from health authorities are lacking, and the specific characteristics of patients requiring higher doses remain unknown. Our objectives were to characterize the patterns of OMA updosing (defined as changes in dose and/or injection intervals), to identify the predictive factors associated with updosing, and to improve CSU management.MethodsWe conducted a prospective, multicentric, real‐life observational study, including patients diagnosed with CSU and starting OMA. The data were collected at 0, 3, 6, and 9 months. The primary endpoint was the frequency of OMA updosing at 3 months. The secondary endpoints included an analysis of updosed patients' profile, and an assessment of OMA efficacy and safety.ResultsWe included 153 patients. Twenty percent of patients were updosed at 3 months, and 27% in total during the 9‐month follow‐up. Practitioners mainly chose to increase the frequency of injections (66%). At baseline, the updosed patients were more likely to have more severe CSU (UCT < 4, p < 0.030), a lower lymphocyte count (<2000/mm3, p = 0.037), and low IgE levels (<70 UI/mL, p = 0.024). The side effects of OMA were not more frequent after updosing.ConclusionOne in five patient underwent updosing within just 3 months. OMA updosing is frequent in particular in cases of severe disease and low IgE blood levels.
Rethinking the relation between human and nature: Insights from science fiction
Authors: Gendron Corinne , Audet René 
Published: July 2024

AbstractFacing the accumulation of data that suggest near‐future dramatic changes in our way of life, current visions of transition are anchored in an incremental paradigm that excludes radical change. Using science fiction literature and cinema, this article aims to build such drastic change hypotheses and explore the political–ecological features of future societies emerging from a rupture phenomenon. These post‐ecological societies need to be imagined and analyzed in order to better prepare for eventual dramatic changes and to engage in prospective exercises that contemplate the possibility of flourishing for all in the future. Our work builds on the idea that other forms of knowledge, such as artistic and creative insights produced by science fiction literature and cinema, are promising sources of imagination and must be engaged in a dialog with sociology and other social sciences in order to develop hypotheses of possible futures. The paper introduces six such hypotheses called “scenarios” that were induced from the systematic study of a body of work in classical science fiction production.
The potential for therapeutic drug monitoring of belatacept and other biologicals in solid organ transplantation
Authors: Bergan Stein , Vethe Nils Tore 
Published: July 2024

AbstractIn solid organ transplantation (SOT), biologicals such as recombinant therapeutic proteins, monoclonal antibodies, fusion proteins and conjugates are increasingly used for immunosuppression, desensitization, ABO (blood group) incompatibility, antibody‐mediated rejections and atypical haemolytic uremic syndrome. In this paper, we review the medical evidence available for biologicals used in SOT and the potential for improvement by the application of therapeutic drug monitoring (TDM) and model‐informed precision dosing. Biologicals are used for off‐label indications within the field of SOT, building on the experience from their use on labelled indications. Dosing is currently mostly standard, and experience vs. effect and toxicity is limited. Pharmacokinetic characteristics of these large, partly also immunogenic molecules differ from those of traditional small molecules. Individualization by concentration measurements and modelling has mostly been proof‐of‐concept or feasibility studies that lack the power to provide evidence for improvement in clinical outcome. For some drugs such as alemtuzumab, eculizumab, rituximab, tocilizumab and belatacept, studies have demonstrated significant interindividual variability in pharmacokinetics. Variability in absorption from subcutaneous administration may increase interindividual variability. There is also an economic aspect of appropriate dosing that needs to be pursued. Available assays and models to refine interpretation are in place, but trials of adequate size to document the usefulness of TDM and MIPD are scarce. Collaboration within the TDM community seems mandatory to establish studies of sufficient strength to provide evidence for the use of biologicals that are currently used off‐label in SOT and furthermore to identify the settings where TDM may be beneficial.
Model‐based population pharmacokinetic and exposure response analyses for safety and efficacy of nivolumab as adjuvant treatment in subjects with resected oesophageal or gastroesophageal junction cancer
Authors: Zhao Yue , Tsujimoto Akihide , Ide Takafumi , Zhang Jenny , Feng Yan , Gao Ling , Bello Akintunde , Roy Amit 
Published: July 2024

AimsNivolumab is approved as adjuvant treatment in subjects with resected oesophageal or gastroesophageal junction cancer (EC/GEJC) based on results from the pivotal CheckMate 577 trial. We present a model‐based clinical pharmacology profiling and benefit–risk assessment of nivolumab as adjuvant treatment in subjects with resected EC/GEJC supporting a less frequent dosing regimen.MethodsPopulation pharmacokinetic (popPK) analysis was conducted to characterize nivolumab pharmacokinetics (PK) using clinical data from 1493 subjects from seven monotherapy clinical studies across multiple solid tumours. The exposure‐response (E‐R) analyses included data from 756 patients from CheckMate 577. E‐R relationships for efficacy and safety were characterized by evaluating the relationship between nivolumab exposure and disease‐free survival (DFS) for efficacy; and time to first occurrence of Grade ≥2 immune‐mediated adverse events (Gr2 + IMAEs) for safety.ResultsNivolumab exposure was found to be associated with both DFS and risk of Gr2 + IMAEs. However, the hazard ratios (HRs) (95% confidence interval [CI]) at the 5th and 95th percentiles of nivolumab exposure were similar for DFS and Gr2 + IMAEs, indicating flat E‐R relationships within the exposure range produced by the studied regimen. Model‐predicted probability of DFS and Gr2 + IMAEs were similar between the two regimens of 240 mg every 2 weeks or 480 mg every 4 weeks for 16 weeks followed by 480 mg Q4W up to 1 year.ConclusionsThe analyses demonstrated a flat E‐R relationship over the range of exposures produced by the studied regimen and supported the approval of an alternative dosing regimen with less frequent dosing in patients with adjuvant EC/GEJC.
Behavioral skill practice as a predictor of mood and family functioning in adolescents with bipolar and depressive mood disorders: Results of a 6‐month randomized trial of family‐focused therapy
Authors: Weintraub Marc J. , Merranko John A. , Ichinose Megan C. , Denenny Danielle M. , Walshaw Patricia D. , Morgan‐Fleming Georga , Brown Robin D. , Arevian Armen C. , Miklowitz David J. 
Published: July 2024

AbstractObjectiveBehavioral interventions require considerable practice of treatment skills in between therapy sessions. The effects of these treatments may vary with the degree to which patients are able to implement these practices. In offspring of parents with bipolar and major depressive disorders, we examined whether youth who frequently practiced communication and problem‐solving skills between family‐focused therapy (FFT) sessions had less severe mood symptoms and better psychosocial functioning over 6 months than youth who practiced less frequently.MethodsWe randomly assigned offspring (ages 12–19) of parents with mood disorders to 12 sessions of FFT plus a mobile app that encouraged the practice of communication, problem‐solving and mood management skills (FFT‐MyCoachConnect [MCC] condition) or 12 sessions of FFT with an app that only allowed for tracking of symptoms and stress (FFT‐Track condition). Independent evaluators assessed youths' mood and psychosocial functioning at 9‐week intervals over 27 weeks. Clinicians rated participants' between‐session skill practice at each FFT session.ResultsFFT‐MCC was associated with more frequent skill practice than FFT‐Track over 18 weeks of treatment. Skill practice was associated with reductions in youths' mood instability and perceptions of family conflict over 27 weeks in both app conditions. Skill practice mediated the effects of app condition on youths' mood instability and family functioning.ConclusionsMobile applications as adjuncts to family therapy for youth with mood disorders can help increase skill practice. These findings provide preliminary causal evidence for behavioral skill practice improving mood symptoms and family functioning among youth with mood disorders.
Discovering novel derivatives of STAT3 and HDAC inhibitors with anti‐tumor activity
Authors: Yang Yu , Pu Yamin , Huang Xiaoli , Liao Mengya , Zhang Yiwen 
Published: July 2024

AbstractIn modern cancer therapy, blockage of more than one target is a standard approach, and there are already many dual‐target drugs that can achieve multiple inhibition through a single molecule. Herein, we designed and synthesized a series of novel derivatives with signal transducer and activator of transcription 3 (STAT3) and histone deacetylase (HDAC) inhibitory activity through strategy of combining pharmacophore based on the STAT3 inhibitor E28 and HDAC inhibitor MS‐275. Among them, compound 24 (IC50 = 8.22 ± 0.27 μM) showed better anti‐tumor activity than the clinical Class I HDAC inhibitor MS‐275 (IC50 = 14.65 ± 0.24 μM) in MCF‐7 breast cancer cells. Furthermore, the dual inhibition to HDAC and STAT3 of compound 24 was validated by western blot analysis. The study provides new tool compounds for further exploration of STAT3–HDAC pathway inhibitor achieved with a single molecule.
How best to support parents in the management of standing frame usage in home settings: A mixed methods study
Authors: Krarup Laerke Hartvig , Holsgaard‐Larsen Anders , Rasmussen Helle Mätzke , Kyed Stine Østergaard , Pawlowski Charlotte Skau 
Published: July 2024

AbstractBackgroundAn improved understanding of the current practice of standing frame use may have implications for supporting parents in managing standing frames. We aimed to investigate how parents of children with cerebral palsy perceive and manage standing frame use in home settings.MethodsWe conducted a mixed methods study with an explanatory sequential design, first collecting and analysing quantitative questionnaire data and then using these results to inform a qualitative follow‐up phase to explain them. The questionnaire was answered by 103 parents of children with cerebral palsy across five countries, Denmark, Norway, Great Britain, Canada and the United States, and 12 Danish families participated in the subsequent interviews. A descriptive analysis was conducted using the questionnaire data. The qualitative data were analysed using a directed content analysis, enabling integration of the quantitative and qualitative data.ResultsThe quantitative analysis showed that 89% of the parents felt confident with their child's standing frame, and 82% felt they had sufficient knowledge about how their child's standing frame could/should be used. However, the qualitative analysis showed that even when feeling confident, the parents experienced insecurity regarding whether their child was positioned correctly, and being responsible for positioning was challenging.ConclusionOur study implies a need for providing educational materials to assist the parents in ensuring optimal positioning of their child in the standing frame to decrease insecurity. Additionally, our study suggests a need to provide more thorough information about the benefits of using a standing frame and ensure alignment of expectations in relation to the child's prognosis of functional independence.
Assessing the acceptability of a culturally adapted group‐based pediatric intervention, Kokajjiriri, for Marshallese mothers and infants to improve nutrition and prevent childhood obesity
Authors: Ayers Britni L. , Short Eliza , Cline Chloe , Ammerman Alice S. , Council Sarah K. , Kabua Philmar Mendoza 
Published: July 2024

AbstractBackgroundMarshallese Pacific Islanders experience higher rates of obesity than other racial and/or ethnic communities. Despite the obesity rates experienced in this community, there are currently no childhood obesity prevention interventions designed for Marshallese Pacific Islanders in the United States. The purpose of this study is to assess the acceptability and feasibility of a culturally adapted group‐based pediatric intervention, Kokajjiriri, with Marshallese mothers to improve nutrition and reduce childhood obesity.MethodsA multi‐methods design was used to culturally adapt the Kokajjiriri intervention for Marshallese mothers in Arkansas (n = 17). In phase one, we conducted 24‐h dietary recalls with 20 Marshallese mothers to inform the cultural adaptation of the group‐based pediatric intervention, and then in phase two, we culturally adapted and piloted three sessions of the intervention to determine the acceptability and feasibility of the intervention.ResultsParticipants found the adapted intervention to be acceptable and feasible, found the location to be convenient and found the facilitator to be knowledgeable. Four themes emerged from the qualitative data: (1) Lactation Support; (2) Introducing Healthy Solids; (3) Rice Portion Control; and (4) Finding Resources.ConclusionsThis is the first study to assess the acceptability and feasibility of a culturally adapted group‐based pediatric intervention, Kokajjiriri, with Marshallese mothers to improve nutrition and reduce childhood obesity. The results from this culturally adapted group‐based pediatric intervention, Kokajjiriri, will be used to inform future adaptations and implementation of the full intervention for Marshallese women and children.
Healthcare providers' perceptions of infant physical activity and communication
Authors: Chaudhary Priyanka , Snyder Kailey , DeVeney Shari , Dinkel Danae 
Published: July 2024

AbstractBackgroundHealthcare providers (HPs) play a critical role in disseminating information about infant health and development. Two key developmental areas for infants are physical activity (PA) and communication. Few studies have examined HPs views of these topics. Thus, HPs may need support to promote these early development outcomes in infants. Thus, the study explored HPs' perceptions of infant PA and communication.MethodsA total of 13 HPs with a wide variety of backgrounds were recruited. Zoom semi‐structured interviews were based on the Health Belief Model. Deductive content analysis was utilized to analyze data.ResultsHPs knew little about PA guidelines. HPs were concerned about an infant's PA because of limited playtime and tummy time. Most HPs advised parents on PA and motor development milestones, with crawling, walking, and tummy time. HPs also wanted to learn about PA measurement tools. PA promotion was hindered by parents' busy schedules, lack of time, and language barriers. Most HPs advised parents on verbal and nonverbal communication. Many HPs were unfamiliar with communication assessment methods and wanted to learn more.ConclusionsHPs had limited knowledge about PA guidelines and communication measurement tools. Efforts are needed to identify easily accessible ways to educate HPs that could be disseminated to parents.
Online occupational therapy group training for mothers of children with feeding problems: A randomized controlled trial
Authors: Koca Rukiye Begum , Akyurek Gokcen 
Published: July 2024

AbstractAimThe aim of this study was to scrutinize how online occupational therapy group training for mothers influenced their attitudes and stress levels relating to feeding their children and the eating behaviours of the children. The secondary purpose of the study is to evaluate the satisfaction of the participants of this program. Twenty‐nine mothers of children aged 3–6 years, experiencing feeding issues, were randomly allocated to either an intervention or control group.BackgroundFeeding problems including selective eating, loss of appetite, and mealtime behaviour problems are prevalent during childhood. Parents play a fundamental role in acquiring knowledge about feeding. Problems in the feeding process may lead to parental stress, feelings of despair, and incorrect attitudes.ResultsThe mothers in the research group participated in the 4‐week training. Results indicated positive effects on both maternal attitudes and their children's eating behaviours (p < 0.05). No significant change was found in mothers' state and trait anxiety levels (p > 0.05). Participants were asked to score their satisfaction level with the program between 1 and 10, and the average of the scores was 9.78 ± 0.42.ConclusionThis study shows that online group education for mothers can support existing treatments and guide clinicians working with children with feeding problems.
Understanding allostasis: Early‐life self‐regulation involves both up‐ and down‐regulation of arousal
Authors: Wass S. V. , Mirza F. U. , Smith C. 
Published: July 2024

AbstractOptimal performance lies at intermediate autonomic arousal, but no previous research has examined whether the emergence of endogenous control associates with changes in children's up‐regulation from hypo‐arousal, as well as down‐regulation from hyper‐arousal. We used wearables to take day‐long recordings from N = 58, 12‐month‐olds (60% white/58% female); and, in the same infants, we measured self‐regulation in the lab with a still‐face paradigm. Overall, our findings suggest that infants who showed more self‐regulatory behaviors in the lab were more likely to actively change their behaviors in home settings moment‐by‐moment “on the fly” following changes in autonomic arousal, and that these changes result in up‐ as well as down‐regulation. Implications for the role of atypical self‐regulation in later psychopathology are discussed.
Insights from the first phylogenomic analysis of flat wasps (Hymenoptera, Bethylidae) reveal two new subfamilies
Authors: Santos Bernardo F. , Colombo Wesley D. , Murray Elizabeth A. , Brady Seán G. , Azevedo Celso O. 
Published: July 2024

AbstractDespite significant advances in alpha level taxonomy in the past few decades, the higher‐level phylogeny of flat wasps (Hymenoptera, Bethylidae) remains poorly explored. Herein we provide the first phylogenomic assessment of the family based on data from ultraconserved elements for 96 species in 61 genera of the family, with material from 29 countries and all biogeographic regions. Dataset cutoffs including ultraconserved element loci recovered for 50 and 70% of terminals resulted in matrices with 1513 and 451 loci, which were analysed in both parsimony and maximum likelihood frameworks. We also provide the first analyses of divergence dating for the family based on the calibration of 12 nodes. All analyses recovered the Bethylidae as a monophyletic group and estimated the origin of the family at around 143 Ma. The results suggest that all extant subfamilies had already diversified by the Late Cretaceous. All topologies suggest that Glenosema and Chilepyris form a clade separate from other Scleroderminae; owing to the morphological distinctiveness of each genus, we propose that they are accommodated in two new subfamilies, Glenoseminae subf. nov. and Chilepyrinae subf. nov. The monotypic sclerodermine genus Galodoxa was consistently recovered within Epyrinae and is transferred to the latter subfamily.
Clinical, radiographic and patient‐reported outcomes of zirconia and titanium implants in the posterior zone after 1 year of loading—A randomized controlled trial
Authors: Zuercher Anina N. , Balmer Marc , Brügger Lily V. , Thoma Daniel S. , Jung Ronald E. , Bienz Stefan P. 
Published: July 2024

AbstractObjectiveTo assess the clinical, radiographic and patient‐reported outcomes (PROMs) of posterior zirconia and titanium implants at 1 year of implant loading.Materials and MethodsForty‐two patients with two adjacent missing teeth were enrolled in a randomized controlled trial with a within‐subject controlled design. Each patient received one zirconia (Zr) and one titanium (Ti) implant, with the mesial and distal positions randomized. The implant restoration consisted of multiple layered zirconia, with the buccal aspect veneered. In group Zr, the restoration was intraorally cemented onto the one‐piece Zr implant, whereas in group Ti, the restoration was extraorally cemented onto the titanium base abutment and intraorally screw‐retained onto the Ti implant. Examinations were performed following restoration delivery at baseline (BL) and at 1 year. Measurements included clinical parameters, radiographic outcomes (MBL) and PROMs.ResultsBleeding on probing showed an increase from BL to 1 year (34 ± 30% for Zr; 25 ± 21% for Ti). MBL remained stable with minimal changes from BL to 1 year, measuring 0.1 ± 0.4 mm (mean ± SD) for Zr and −0.1 ± 0.7 mm for Ti. Veneering fractures were the most frequent technical complication and amounted to 17.5% in group Zr and 5% in group Ti (p = .100). Patients preferred Zr implants for their soft tissue color, with a significant difference in perception between patients and clinicians (p < .017).ConclusionThe study showed that both Zr and Ti implants had similar clinical outcomes, despite a high prevalence of mucositis and a few technical complications. Both implant types demonstrated stable marginal bone levels and similar patient‐reported outcome measures.