bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrologic Implications of Different Large-Scale Meteorological Model Forcing Datasets in Mountainous Regions
Authors: Mizukami Naoki , P. Clark Martyn , G. Slater Andrew , D. Brekke Levi , M. Elsner Marketa , R. Arnold Jeffrey , Gangopadhyay Subhrendu 
Published: August 2013

Abstract
Process-based hydrologic models require extensive meteorological forcing data, including data on precipitation, temperature, shortwave and longwave radiation, humidity, surface pressure, and wind speed. Observations of precipitation and temperature are more common than other variables; consequently, radiation, humidity, pressure, and wind speed often must be either estimated using empirical relationships with precipitation and temperature or obtained from numerical weather prediction models. This study examines two climate forcing datasets using different methods to estimate radiative energy fluxes and humidity and investigates the effects of the choice of forcing data on hydrologic simulations over the mountainous upper Colorado River basin (293 472 km2). Comparisons of model simulations forced by two climate datasets illustrate that the methods used to estimate shortwave radiation impact hydrologic states and fluxes, particularly at high elevation (e.g., ~20% difference in runoff above 3000-m elevation), substantially altering the timing of snowmelt and runoff (~20 days difference) and the partitioning of precipitation between evapotranspiration and runoff. The different forcing datasets also exhibit differences in hydrologic sensitivity to interannual temperature at high elevation. The results suggest that the choice of forcing dataset is an important consideration when conducting climate impact assessments and the subsequent applications of these assessments for water resources planning and management.
Perceived tutor benefits of teaching near peers: insights from two near peer teaching programmes in South East Scotland
Authors: Qureshi ZU , Gibson KR , Ross MT , Maxwell S 
Published: August 2013

Background and aims There is little evidence about the benefits to junior doctors of participating in teaching, or how to train doctors as teachers. We explore (through South East Scotland based teaching programmes): (a) How prepared do junior doctors feel to teach? (b) What junior doctors consider to be the main challenges of teaching? (c) What motivates the junior doctors to continue teaching, and what is the perceived impact of teaching on their professional development? Methods and results ‘Questionnaire 1’, distributed at ‘tutor training days’, explored (i) attitudes towards teaching and (ii) tutors’ preparedness to teach. ‘Questionnaire 2’, distributed after completion of a teaching programme, evaluated the tutor experience of teaching. Results Seventy-six per cent of tutors reported no previous teacher training; 10% were able to teach during allocated work hours. The strongest motivation for teaching was to help students with their learning and to develop teaching skills. Ninety one per cent of tutors felt more prepared to teach by the end of the programme. Tutors also improved their clinical skills from teaching. Conclusions There is a body of junior doctors, who see teaching as an important part of their career, developing both teaching and clinical skills in the tutor. If teaching is expected of foundation doctors, rotas ought to be more flexible to facilitate both teaching and teacher training.
Nineteenth century mortality at the Royal Hospital for Sick Children, Glasgow
Authors: Cullis PS , Young DG 
Published: August 2013

Background and aims Since Glasgow’s Royal Hospital for Sick Children opened in 1882, significant advances have been made in child health. Our aim was to investigate the hospital mortality that occurred in the last decade of the 19th century at Royal Hospital for Sick Children. Methods and results Hospital mortality records for the decades, 1890–1899, were collected from the Archives of the Royal Hospital for Sick Children. Data were extracted from the hospital inpatient records and the pathology records. In the decade 1890–1899, there were 731 hospital deaths. The main cause of death at that time in the 19th Century was infection, particularly of the respiratory tract. The age at which death occurred was analysed and the recorded cause were analysed as was the distance patients travelled to the hospital. The ratio of boys to girls and length of inpatient stay was similar to that seen in the hospital currently. Conclusion This study records the mortality in a children’s hospital in a large developing industrial city in the 19th century as experienced in a children’s hospital.
The epidemiology and management of adult poisonings admitted to the short-stay ward of a large Scottish emergency department
Authors: Teo AIC , Cooper JG 
Published: August 2013

Background and aims The emergency department of Aberdeen Royal Infirmary receives around 68,000 new adult admissions annually. All poisoning cases are admitted to a 14-bedded short-stay ward, except those admitted to intensive care or immediately discharged. This study aimed to analyse epidemiological trends and management of short-stay ward admissions for poisonings. Method and results Adult (>13 years) poisoning presentations admitted to the emergency department short-stay ward of Aberdeen Royal Infirmary from 1 January–31 December 2009 were retrospectively reviewed using patient discharge summaries. During 2009, there were 1062 poisoning cases, of which repeat episodes were responsible for 15%. The mean age of presentation was 33.9 years (SD 14.4) and there was a female preponderance (62%). Almost half of poisonings were polypharmacy, alcohol was involved in 40% of cases and overdoses most commonly involved paracetamol (43%). Management involved basic observations only (66%), N-acetylcysteine (24%), naloxone (4%) and activated charcoal (1%). Liaison psychiatry reviewed 84% presentations and admitted 9% to the psychiatric unit. Conclusions The short-stay ward is important for acute management of poisonings and the data gained from this study should help to direct patient services appropriately.
The role of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography in the management of patients with carcinoma of unknown primary
Authors: Deonarine P , Han S , Poon FW , de Wet C 
Published: August 2013

Purpose Carcinoma of unknown primary is one of the ten most frequent cancers worldwide. Its median survival time is less than 10 months. Detecting primary tumour locations and/or occult metastatic lesions may inform definitive treatment and improve patients’ prognosis. We aimed to determine: (1) the sensitivity, specificity and accuracy of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography; (2) its detection rate of primary tumour locations and occult metastases and (3) factors associated with improved survival times. Methods We retrospectively reviewed all cases in the West of Scotland for the period 1 December 2007 to 31 May 2011 that met all our selection criteria: (1) diagnosis of carcinoma of unknown primary; (2) a thorough but negative ‘work-up’ and (3) 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography report. Statistical methods included frequencies, Kaplan-Meier graphs and log-rank tests to compare survival times. Results 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography detected primary tumour sites in 19/51 (37.3%) and occult metastases in 28/51 (54.9%) of eligible patients. Its sensitivity, specificity and accuracy were 79.2%, 70.4% and 74.5%, respectively; 20/51 (39.2%) patients died during the study period with a median survival of 8.4 months (range 21.4, SD ± 6.2). The number of metastatic locations was strongly associated with survival ( p = 0.002), but detection of a primary tumour site ( p = 0.174) or histopathology ( p = 0.301) was not. Conclusion 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography detected occult metastatic sites in the majority and a primary cancer location in a substantial minority of patients. Our results were comparable with international literature and may indicate that 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography have an early role to improve the accuracy of cancer staging and to optimise carcinoma of unknown primary management.
Inflammatory myofibroblastic tumor with extensive involvement of the bladder in an adolescent: a case report
Authors: Yi Xin Lin , Lu Hao Yuan , Wu Yue Xian , Li Wen Hui , Meng Qing Gui , Cheng Ji Weng , Tang Yong , Liu Yu , Bai Xian Zhong 
Published: August 2013

Abstract
Inflammatory myofibroblastic tumor (IMT) is a rare lesion of unclear pathogenesis that shows a wide, highly variable spectrum of clinical behavior. We describe the case of a 17-year-old boy with a large IMT that infiltrated the bladder, ileocecal junction, peritoneum and pelvic retroperitoneal space. The tumor was associated with extensive toughening and thickening of the bladder, and, although it showed a tendency for invasive growth, it affected mainly the bladder and adjacent tissue. To the best of our knowledge, this case report is the first to describe an IMT involving the entire bladder and several adjacent pelviabdominal organs. The bladder wall was tough and could hardly be cut by scalpel. Levels of inflammatory response markers such as C-reactive protein fell after surgery.
Evaluating a community-based early childhood education and development program in Indonesia: study protocol for a pragmatic cluster randomized controlled trial with supplementary matched control group
Authors: Pradhan Menno , Brinkman Sally A , Beatty Amanda , Maika Amelia , Satriawan Elan , de Ree Joppe , Hasan Amer 
Published: August 2013

Abstract

Background
This paper presents the study protocol for a pragmatic cluster randomized controlled trial (RCT) with a supplementary matched control group. The aim of the trial is to evaluate a community-based early education and development program launched by the Government of Indonesia. The program was developed in collaboration with the World Bank with a total budget of US$127.7 million, and targets an estimated 738,000 children aged 0 to 6 years living in approximately 6,000 poor communities. The aim of the program is to increase access to early childhood services with the secondary aim of improving school readiness.

Methods/Design
The study is being conducted across nine districts. The baseline survey contained 310 villages, of which 100 were originally allocated to the intervention arm, 20 originally allocated to a 9-month delay staggered start, 100 originally allocated to an 18-month delay staggered start and 90 allocated to a matched control group (no intervention). The study consists of two cohorts, one comprising children aged 12 to 23 months and the other comprising children aged 48 to 59 months at baseline. The data collection instruments include child observations and task/game-based assessments as well as a questionnaire suite, village head questionnaire, service level questionnaires, household questionnaire, and child caretaker questionnaire. The baseline survey was conducted from March to April 2009, midline was conducted from April to August 2010 and endline conducted early 2013. The resultant participation rates at both the district and village levels were 90%. At the child level, the participation rate was 99.92%. The retention rate at the child level at midline was 99.67%.

Discussion
This protocol paper provides a detailed record of the trial design including a discussion regarding difficulties faced with compliance to the randomization, compliance to the dispersion schedule of community block grants, and procurement delays for baseline and midline data collections. Considering the execution of the program and the resultant threats to the study, we discuss our analytical plan and intentions for endline data collection.

Trials registration
Current Controlled Trials ISRCTN76061874
Steroids or pentoxifylline for alcoholic hepatitis (STOPAH): study protocol for a randomised controlled trial
Authors: Forrest Ewan , Mellor Jane , Stanton Louise , Bowers Megan , Ryder Priscilla , Austin Andrew , Day Christopher , Gleeson Dermot , O’Grady John , Masson Steven , McCune Anne , Patch David , Richardson Paul , Roderick Paul , Ryder Stephen , Wright Mark , Thursz Mark 
Published: August 2013

Abstract

Background
Alcoholic hepatitis is the most florid presentation of alcohol-related liver disease. In its severe form, defined by a Maddrey’s discriminant function (DF) ≥32, the 28-day mortality rate is approximately 35%. A number of potential treatments have been subjected to clinical trials, of which two, corticosteroids and pentoxifylline, may have therapeutic benefit. The role of corticosteroids is controversial as trial results have been inconsistent, whereas the role of pentoxifylline requires confirmation as only one previous placebo-controlled trial has been published.

Methods/design
STOPAH is a multicentre, double-blind, factorial (2 × 2) trial in which patients are randomised to one of four groups:

Group A: placebo / placebo

Group B: placebo / prednisolone

Group C: pentoxifylline / placebo

Group D: pentoxifylline / prednisolone

The trial aims to randomise 1,200 patients with severe alcoholic hepatitis, in order to provide sufficient power to determine whether either of the two interventions is effective. The primary endpoint of the study is mortality at 28 days, with secondary endpoints being mortality at 90 days and 1 year.

Discussion
STOPAH aims to be a definitive study to resolve controversy around the existing treatments for alcoholic hepatitis. Eligibility criteria are based on clinical parameters rather than liver biopsy, which are aligned with standard clinical practice in most hospitals. The use of a factorial design will allow two treatments to be evaluated in parallel, with efficient use of patient numbers to achieve high statistical power.

Trial registration
EudraCT reference number: 2009-013897-42
ISRCTN reference number: ISRCTN88782125
Identification of genuine primary pulmonary NK cell lymphoma via clinicopathologic observation and clonality assay
Authors: Gong Li , Wei Long-Xiao , Huang Gao-Sheng , Zhang Wen-Dong , Wang Lu , Zhu Shao-Jun , Han Xiu-Juan , Yao Li , Lan Miao , Li Yan-Hong , Zhang Wei 
Published: August 2013

Abstract

Abstract
Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is an uncommon lymphoma associated with the Epstein-Barr virus (EBV). It most commonly involves the nasal cavity and upper respiratory tract. Primary pulmonary NK/T cell lymphoma is extremely rare. If a patient with a NK or T-cell tumor has an unusual reaction to treatment or an unusual prognosis, it is wise to differentiate NK from T-cell tumors. The clinicopathologic characteristics, immunophenotype, EBV in situ hybridization, and T cell receptor (TCR) gene rearrangement of primary pulmonary NK cell lymphoma from a 73-year-old Chinese woman were investigated and the clonal status was determined using female X-chromosomal inactivation mosaicism and polymorphisms at the phosphoglycerate kinase (PGK) gene. The lesion showed the typical histopathologic characteristics and immunohistochemical features of NK/T cell lymphoma. However, the sample was negative for TCR gene rearrangement. A clonality assay demonstrated that the lesion was monoclonal. It is concluded that this is the first recorded case of genuine primary pulmonary NK cell lymphoma. The purpose of the present work is to recommend that pathologists carefully investigate the whole lesion to reduce the likelihood that primary pulmonary NK cell lymphoma will be misdiagnosed as an infectious lesion. In addition, TCR gene rearrangement and clonal analysis, which is based on female X-chromosomal inactivation mosaicism and polymorphisms at PGK and androgen receptor (AR) loci, were found to play important roles in differentiating NK cell lymphoma from T cell lymphoma.

Virtual slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5205300349457729
Who contributes? A strategic approach to a European immigration policy
Authors: Russo Giuseppe , Senatore Luigi 
Published: August 2013

Abstract
Who pays for immigration control? According to the Lisbon Treaty the cost of enforcing the European border against illegal immigration shall be shared among the EU members. Nonetheless, the Treaty is vague with respect to the “appropriate measures” to adopt in order to distribute the financial burden. Members who do not share their borders with source countries have an incentive to free ride on the other countries. We study a novel contribution game in which a border country and a central country minimize a loss function with respect to their national immigration target. We consider both sequential and simultaneous decisions and we show that joint contribution occurs only if the immigration targets are not too different. Total contribution is higher in the simultaneous game, but the sequential framework reduces the incentive to free ride.

Jel codes D78, H72, H77
Multiparameter TTI tomography of P-wave reflection and VSP data
Authors: Wang Xiaoxiang , Tsvankin Ilya 
Published: August 2013

Transversely isotropic models with a tilted symmetry axis (TTI media) are widely used in depth imaging of complex geologic structures. Here, we present a modification of a previously developed 2D P-wave tomographic algorithm for estimating heterogeneous TTI velocity fields and apply it to synthetic and field data. The symmetry-direction velocity [Formula: see text], anisotropy parameters [Formula: see text] and [Formula: see text], and symmetry-axis tilt [Formula: see text] are defined on a rectangular grid. To ensure stable reconstruction of the TTI parameters, reflection data are combined with walkaway vertical seismic profiling (VSP) traveltimes in joint tomographic inversion. To improve the convergence of the algorithm, we develop a three-stage model-updating procedure that gradually relaxes the constraints on the spatial variations of the anisotropy parameters, while the symmetry axis is kept orthogonal to the reflectors. Only at the final stage of the inversion are the parameters [Formula: see text], [Formula: see text], and [Formula: see text] updated on the same grid. We also incorporate geologic constraints into tomography by designing regularization terms that penalize parameter variations in the direction parallel to the interfaces. First, we examine the performance of the regularized joint tomography of reflection and VSP data for two sections of the BP TTI model that contain an anticline and a salt dome. All three TTI parameters in the shallow part of both sections (down to 5 km) are well resolved by the proposed model-updating process. Then, the algorithm is applied to a 2D section from 3D ocean-bottom seismic data acquired at Volve field in the North Sea. The inverted TTI model produces well-focused reflectors throughout the section and accurately positions the key horizons, which is confirmed by the available well markers.
Implications of pore microgeometry heterogeneity for the movement and chemical reactivity of CO2 in carbonates
Authors: Vialle Stéphanie , Dvorkin Jack , Mavko Gary 
Published: August 2013

We studied the heterogeneity of natural rocks with respect to their pore-size distribution, obtained from mercury-intrusion capillary pressure (MICP) tests, at a scale about one-fifth of the standard plug size (2.5 cm). We investigated two Fontainebleau sandstone and two limestone samples. We found that at the scale of the MICP tests, heterogeneities are practically nonexistent. Still, there are large differences in the capillary curves from one rock type to another. Also, carbonate rocks, unlike Fontainebleau sandstone, show heterogeneities at a scale smaller than the scale used in MICP tests, as seen by the complexity in the mercury saturation versus pressure curves. We used this diversity between the capillary curves and this complexity within a single capillary curve to obtain information about the movement and chemical reactivity of [Formula: see text] in carbonates. The method consists of three steps: first, subdividing the carbonate pore system into microstructural facies, each of them having a specific range of pore throat size (e.g., tight micrite, microporous rounded micrite, small vugs, …); second, getting a characteristic value of their petrophysical properties (namely porosity, effective surface area, and permeability) from the collected MICP data; and third, computing, for experimental conditions corresponding to a transport-controlled system, the dimensionless Péclet and Damköhler numbers, expressed as a function of the aforementioned permeability and effective surface area. These numbers allowed us to infer the dominant process (i.e., diffusion, advection, or kinetics) controlling the dissolution/precipitation reaction induced by the carbonic acid. Because of heterogeneities in the pore microstructure, we found that either diffusion or advection is locally the dominant mechanism, which renders some zones (e.g., vugs or, to a lesser extent, microporous rounded micrite) chemically more reactive than others (e.g., tight micrite or spar cement).
Mff functions with Pex11pβ and DLP1 in peroxisomal fission
Authors: Itoyama Akinori , Michiyuki Satoru , Honsho Masanori , Yamamoto Taizo , Moser Ann , Yoshida Yumi , Fujiki Yukio 
Published: August 2013

Summary
Peroxisomal division comprises three steps: elongation, constriction, and fission. Translocation of dynamin-like protein 1 (DLP1), a member of the large GTPase family, from the cytosol to peroxisomes is a prerequisite for membrane fission; however, the molecular machinery for peroxisomal targeting of DLP1 remains unclear. This study investigated whether mitochondrial fission factor (Mff), which targets DLP1 to mitochondria, may also recruit DLP1 to peroxisomes. Results show that endogenous Mff is localized to peroxisomes, especially at the membrane-constricted regions of elongated peroxisomes, in addition to mitochondria. Knockdown of MFF abrogates the fission stage of peroxisomal division and is associated with failure to recruit DLP1 to peroxisomes, while ectopic expression of MFF increases the peroxisomal targeting of DLP1. Co-expression of MFF and PEX11β, the latter being a key player in peroxisomal elongation, increases peroxisome abundance. Overexpression of MFF also increases the interaction between DLP1 and Pex11pβ, which knockdown of MFF, but not Fis1, abolishes. Moreover, results show that Pex11pβ interacts with Mff in a DLP1-dependent manner. In conclusion, Mff contributes to the peroxisomal targeting of DLP1 and plays a key role in the fission of the peroxisomal membrane by acting in concert with Pex11pβ and DLP1.
Titanium dioxide nanoparticles and the oral uptake-route
Authors: Fröhlich Eleonore , Teubl Birgit Johanna , Roblegg Eva 
Published: August 2013

AbstractTitanium dioxide (TiO2) is a common additive that is increasingly used in consumer products, food, pharmaceutical dosage forms and cosmetic articles. However, due to size reduction of TiO2 particles from the microscale to the nanoscale, application areas of this material are expanding, especially in the food sector, which makes investigations of nano-TiO2 crucial. This review focuses on two important topics of current research regarding the oral pathway: 1) anatomy of the orogastrointestinal tract, composition of epithelial and mucus layer, and pH changes; 2) cell entry mechanisms, cytotoxicity and translocation. Sufficient knowledge on the oral uptake route is not yet available but is highly needed for human risk evaluation.