bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Quality-of-Care Disparities in Childhood Asthma:La Red de Asma InfantilIntervention in San Juan, Puerto Rico
Authors: Lara Marielena , Ramos-Valencia Gilberto , González-Gavillán Jesús A. , López-Malpica Fernando , Morales-Reyes Beatriz , Marín Heriberto , Rodríguez-Sánchez Mario H. , Mitchell Herman 
Published: March 2013

BACKGROUND AND OBJECTIVEAlthough children living in Puerto Rico have the highest asthma prevalence of all US children, little is known regarding the quality-of-care disparities they experience nor the adaptability of existing asthma evidence-based interventions to reduce these disparities. The objective of this study was to describe our experience in reducing quality-of-care disparities among Puerto Rican children with asthma by adapting 2 existing evidence-based asthma interventions.METHODS:We describe our experience in adapting and implementing 2 previously tested asthma evidence-based interventions: the Yes We Can program and the Inner-City Asthma Study intervention. We assessed the feasibility of combining key components of the 2 interventions to reduce asthma symptoms and estimated the potential cost savings associated with reductions in asthma-related hospitalizations and emergency department visits. A total of 117 children with moderate and severe asthma participated in the 12-month intervention in 2 housing projects in San Juan, Puerto Rico. A community-academic team with the necessary technical and cultural competences adapted and implemented the intervention.RESULTS:Our case study revealed the feasibility of implementing the combined intervention, henceforth referred to as La Red intervention, in the selected Puerto Rican communities experiencing a disproportionately high level of asthma burden. After 1-year follow-up, La Red intervention significantly reduced asthma symptoms and exceeded reductions of the original interventions. Asthma-related hospitalizations and emergency department use, and their associated high costs, were also significantly reduced.CONCLUSIONS:Asthma evidence-based interventions can be adapted to improve quality of care for children with asthma in a different cultural community setting.
National Quality Measures for Child Mental Health Care: Background, Progress, and Next Steps
Authors: Zima Bonnie T. , Murphy J. Michael , Scholle Sarah Hudson , Hoagwood Kimberly Eaton , Sachdeva Ramesh C. , Mangione-Smith Rita , Woods Donna , Kamin Hayley S. , Jellinek Michael 
Published: March 2013

OBJECTIVE:
To review recent health policies related to measuring child health care quality, the selection processes of national child health quality measures, the nationally recommended quality measures for child mental health care and their evidence strength, the progress made toward developing new measures, and early lessons learned from these national efforts.

METHODS:
Methods used included description of the selection process of child health care quality measures from 2 independent national initiatives, the recommended quality measures for child mental health care, and the strength of scientific evidence supporting them.

RESULTS:
Of the child health quality measures recommended or endorsed during these national initiatives, only 9 unique measures were related to child mental health.

CONCLUSIONS:
The development of new child mental health quality measures poses methodologic challenges that will require a paradigm shift to align research with its accelerated pace.
Do Parent Perceptions Predict Continuity of Publicly Funded Care for Attention-Deficit/Hyperactivity Disorder?
Authors: Zima Bonnie T. , Bussing Regina , Tang Lingqi , Zhang Lily 
Published: March 2013

OBJECTIVE:
To examine whether parent perceptions about care (barriers, disorder knowledge, treatment willingness) vary among children who drop out of or stay in publicly funded care for attention-deficit/hyperactivity disorder (ADHD) and to explore whether parent perceptions are predictive of staying in care over time.

METHODS:
A longitudinal cohort study of 529 children ages 5 to 11 years receiving care for ADHD in primary care or specialty mental health clinics in a large, countywide, managed-care Medicaid program. Multiple logistic regression analyses were performed to identify parent perceptions associated with the likelihood of staying in care across three 6-month time intervals, controlling for child and parent demographic characteristics, parental distress, clinical need, and recent special education use.

RESULTS:
At least three-fourths of children had at least 1 contact for any mental health care during a 6-month time interval (75%, 85%, 76%). Parent-perceived barriers, ADHD knowledge, and counseling willingness did not predict staying in care, whereas willingness for medication treatment was predictive at baseline. Minority status, nonmarried parent, parental distress, clinical need, and special education use were predictive of staying in care, but mostly during only one 6-month time interval, and their influence varied over time.

CONCLUSIONS:
Parent willingness for medication treatment along with several demographic and need factors predicted staying in care but not consistently over time. Future research is needed to develop practical tools for clinicians to elicit parent priorities about ADHD treatment and to integrate them into quality-improvement interventions targeted to improving shared decision-making for longer term ADHD care.
Annealing Behavior of Locally Confined Dislocation Loops Under Inert And Oxidizing Ambient
Authors: Tsamis C. , Skarlatos D. , Raptis I. , Tsoukalas D. , Calvo P. , Colombeau B. , Cristiano F. , Claverie A. 
Published: March 2013

AbstractIn this work, we report data for the growth kinetics of locally confined dislocation loops organized within lines of controlled dimension and periodicity. The dislocation loop lines were formed in the crystalline substrate after local Si implantation and annealing in predefined areas. The distance between the lines ranges between 0.2 νm to 5 μm. It is shown that the kinetics of the DLs depends on the distance between them. When the distance is less than 1 μm, the DLs behave in a similar fashion like those grown in a continuous layer, under inert and oxidizing conditions. However, when the distance between the lines is increased (eg. 5 μm), the behavior of the loops is changed. Fast dissolution of the dislocations loops is observed during annealing in inert ambient, due to enhanced interstitial losses, while under oxidizing conditions the loops grow faster.
Periodontal Tissue and Serum Concentration of Clarithromycin After Systemic Administration in Patients Affected by Chronic Periodontitis
Authors: Raghunatha K. , George Joann P. 
Published: March 2013

Background: During the past two decades, dentists and microbiologists have relied on periodontal antibiotic therapy in the management of periodontitis. This association has accumulated and strengthened exponentially. Macrolides attain high therapeutic concentrations in infected tissue, so they are potentially a good choice for inhibiting invasive periodontal pathogens. Clarithromycin accumulates in phagocytes, monocytes, fibroblasts, polymorphonuclear cells, macrophages, and lymphocytes. These cells are more numerous at inflamed sites, so it is reasonable to expect clarithromycin levels to be higher in periodontally diseased sites. This study determines the distribution profile of clarithromycin in the gingiva of patients with periodontitis compared to serum after systemic administration of clarithromycin.Methods: Twenty patients (14 males and six females, aged 25 to 45 years) with chronic periodontitis were enrolled in the study. Gingival index and plaque index were recorded at baseline and 3 days after administration of 500 mg clarithromycin, twice daily, for 3 days. Intravenous blood and biopsy of periodontal tissue samples were taken on the third day. These samples were analyzed for detection of clarithromycin concentration using high‐performance liquid chromatography.Results: Approximately 6 hours after the last dose of clarithromycin, mean clarithromycin concentrations in serum and periodontal tissue were 0.465 μg/mL and 2.61 μg/g, respectively, and the difference was statistically significant.Conclusions: Clarithromycin can attain higher levels in gingiva than serum of patients with periodontitis. This distribution profile of clarithromycin can thus be advantageous in the management of periodontal lesions.
The Significance of Keratinized Mucosa on Implant Health: A Systematic Review
Authors: Lin Guo‐Hao , Chan Hsun‐Liang , Wang Hom‐Lay 
Published: March 2013

Background: Whether a minimal width of keratinized mucosa (KM) is required to maintain peri‐implant tissue health has been a topic of interest. This systematic review and meta‐analysis aims to investigate the effect of KM on various peri‐implant health‐related parameters.Methods: An electronic search of five databases (from 1965 to October 2012) and a hand search of peer‐reviewed journals for relevant articles were performed. Human cross‐sectional or longitudinal studies with data on the relationship between the amount of KM around dental implants and various peri‐implant parameters, with a follow‐up period of at least 6 months, were included.Results: Eleven studies, seven cross‐sectional and four longitudinal, were included. Weighted mean difference (WMD) and confidence interval (CI) were calculated with meta‐analyses for each clinical parameter. The results showed statistically significant differences in plaque index (PI) and modified PI (WMD = −0.27, 95% CI = −0.43 to −0.11), modified gingival index (mGI) (WMD = −0.48, 95% CI = −0.70 to −0.27), mucosal recession (MR) (WMD = −0.60 mm, 95% CI = −0.85 to −0.36 mm), and attachment loss (AL) (WMD = −0.35 mm, 95% CI = −0.65 mm to −0.06 mm), all favoring implants with wide KM. However, comparisons of other parameters (bleeding on probing, modified bleeding index, GI, probing depth, and radiographic bone loss) did not reach statistically significant differences. The result of heterogeneity test showed only one parameter (AL, P value for the χ2 test = 0.30 and I2 test = 18%) had a low degree of heterogeneity among analyzed studies; meta‐analyses of other parameters presented moderate‐to‐high degree of heterogeneity. Limitations of the present review include limited number of selected studies (n = 11), existence of heterogeneity and publication bias, and only English‐written articles searched.Conclusion: Based on current available evidence, a lack of adequate KM around endosseous dental implants is associated with more plaque accumulation, tissue inflammation, MR, and AL.
Immunosuppression for Membranous Nephropathy
Authors: Chen Yizhi , Schieppati Arrigo , Cai Guangyan , Chen Xiangmei , Zamora Javier , Giuliano Giovanni A. , Braun Norbert , Perna Annalisa 
Published: March 2013

Summary

Background and objectives
The efficacy and safety of immunosuppression for idiopathic membranous nephropathy (IMN) with nephrotic syndrome are still controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was performed.

Design, setting, participants, & measurements
The Cochrane Library, PUBMED, EMBASE, Chinese Database, and Clinical Trial Registries (June 2012) were searched to identify RCTs investigating the effect of immunosuppression on adults with IMN and nephrotic syndrome.

Results
This review was an update (36 RCTs, 1762 participants) of the 2004 version (18 RCTs, 1025 participants). Immunosuppression significantly reduced all-cause mortality or ESRD (15 RCTs, 791 participants; risk ratio, 0.58 [95% confidence interval, 0.36–0.95]; P=0.03). However, the result was not consistent when prespecified subgroup analyses were undertaken. Immunosuppression increased complete or partial remission (CR + PR) (16 RCTs, 864 participants; 1.31 [1.01–1.70]; P=0.04) but resulted in more withdrawals or hospitalizations (16 RCTs, 880 participants; 5.35 [2.19–13.02]; P=0.002). Corticosteroids combined with alkylating agents significantly reduced all-cause mortality or ESRD (8 RCTs, 448 participants; 0.44 [0.26–0.75]; P=0.002) and increased CR + PR (7 RCTs, 422 participants; 1.46 [1.13–1.89]; P=0.004) but led to more adverse events (4 RCTs, 303 participants; 4.20 [1.15–15.32]; P=0.03). Cyclophosphamide was safer than chlorambucil (3 RCTs, 147 participants; 0.48 [0.26–0.90]; P=0.02). Cyclosporine and mycophenolate mofetil failed to show superiority over alkylating agents. Tacrolimus and adrenocorticotropic hormone significantly reduced proteinuria.

Conclusions
Alkylating agents plus corticosteroids had long-term and short-term benefits for adult IMN, but resulted in more withdrawals or hospitalizations.
Revenue and Branding Strategy in the Norwegian News Market
Authors: Sjøvaag Helle 
Published: March 2013

Abstract
Future revenue streams for journalism are said not to lie in breaking news, but in specialist journalism that can engender income to sustain news production. A case study of the Norwegian TV 2 News Channel, however, shows that its profit-making features lie not in its content but in its mode of distribution. The added value of the channel to DTT subscription packages is as much due to TV 2’s market power and news brand value as to the news channel concept itself. This article analyses the function of the news channel in today’s competitive journalistic landscape from the perspective of news sociology and media economy, presenting a quantitative content analysis of the news output of TV 2 News Channel, qualitative interviews with TV 2 news editors, and analysis of key strategy documents of the organization.
Letter to Editor: Impact of labor on uterine scar healing
Authors: Roberge Stéphanie , Bujold Emmanuel 
Published: March 2013

Abstract
Ultrasound of uterine scar after cesarean and measurement of its thickness can be used to evaluate its healing and risk factors for scar defect and uterine rupture. However, we believe that a period of up to 6 months after surgery is necessary to achieve complete healing of the scar, especially in cases of cesarean performed during labor.
Fabrication and characterization of polysilane: PCBM bulk heterojunction solar cells
Authors: Yoshida Kazumi , Oku Takeo , Suzuki Atsushi , Akiyama Tsuyoshi , Tokumitsu Katsuhisa , Nakamura Mika , Yamada Masahiro 
Published: March 2013

Abstract
Polysilane/fullerene bulk heterojunction solar cells were fabricated on indium tin oxide electrodes by a spin-coating method, and performance and microstructures of the solar cells were investigated. Decaphenylcyclopentasilane (PDPS), polymethlyphenylsilane (PMPS) and [6,6]-phenyl C61-butyric acid methyl ester (PCBM) were used for the solar cells. The conversion efficiencies of PDPS:PCBM solar cells were higher than those of PMPS:PCBM devises. Transmission electron microscopy and X-ray diffraction indicated that PDPS:PCBM layer had a nanocomposite structure.
Sidonie ou la compulsion suicidaire
Authors: Boissière Loïc 
Published: March 2013

Avec Sidonie, nous nous proposons d’interroger ici la dynamique d’entrée dans un processus compulsionnel de répétition suicidaire, des confins de l’adolescence jusqu’à l’orée de l’âge adulte. Nous faisons l’hypothèse qu’à partir d’une perte originelle et traumatique, impossible à intégrer, a pu s’initier, dans l’« après-coup », le processus suicidaire. Nous supposons encore qu’au-delà de la répétition « après-coup » de raptus traumatiques, réactionnels à la survenue réitérée d’évènements externes, a pu s’installer par la suite, et peut-être dans la cohabitation, une véritable compulsion à l’acte suicidaire. Celle-ci pourrait procéder en son origine de difficultés spécifiques du traitement de la perte et d’une inhibition de la conflictualité intrapsychique, dont les conséquences seraient l’impossible élaboration d’une souffrance dépressive inextinguible et des mouvements destructeurs qu’elle peut susciter à l’endroit des objets internes. Enfin, par delà ce glissement d’un processus réactionnel à un processus compulsionnel de répétition suicidaire, nous posons la question de l’évolution vers un « besoin de répétition », « au-delà du principe de plaisir », au terme d’une désunion pulsionnelle au long cours et d’un procès naissant de désobjectalisation.
Le dispositif d'évaluation dans la pratique clinique de l'expertise judiciaire : un initiateur au changement ?
Authors: Ravit Magali , Di Rocco Vincent 
Published: March 2013

Les auteurs interrogent la particularité du dispositif expertal, point de jonction et de tension entre le discours juridique et l’investigation clinique de tout autre nature. La particularité de ce dispositif clinique est envisagée selon trois axes qui conditionnent le cadre de la pratique : 1) le dispositif expertal est conduit par un processus associatif dans lequel les méthodes projectives permettent d’organiser une lecture clinique des processus qui s’y déploient ; 2) l’expertise est un acte de co-construction dans la mesure où l’histoire du sujet se construit dans une relation intersubjective où le clinicien rassemble les éléments déployés et organisés selon la narrativité, mais il prend aussi en compte des éléments plus primaires échappant à l’organisation du langage ; 3) cette rencontre est mue par un processus d’affectation du sujet dans l’autre, le sujet s’adressant à un autre-sujet semblable et différent. Deux vignettes cliniques appuieront ces propositions.
Le bilan psychologique dans les cliniques « périnévrotiques » en période de latence
Authors: Boucherat-Hue Valérie 
Published: March 2013

Les consultations de pédopsychiatrie sont motivées pour moitié pour des enfants en âge de latence et les motifs concernent classiquement des difficultés liées à la réussite et/ou à l’intégration scolaire. Dans les contextes cliniques d’ordre « périnévrotique », dominés par la massivité de l’inhibition intellectuelle et parfois motrice, le bilan psychologique aide à saisir la problématique psycho-affective qui sous-tend les entraves scolaires lorsqu’elles entrent dans le cadre d’une intelligence normale. Quelques rappels sur les aménagements psychiques attendus en latence permettront d’introduire la présentation du cas clinique d’une fillette de 8 ans dont l’examen psychologique révèle des aspects psychopathologiques inattendus et permet de préciser la problématique affective de l’enfant en référence aux modèles psychodynamiques de la latence. Chemin faisant, la question sera posée de savoir si les symptômes névrotiques, lorsqu’ils sont massifs et grèvent l’organisation de la latence, sont à considérer comme des rejetons « pseudo-névrotiques » ? Comment ne pas rabattre cette clinique sur les destins et pronostics des états-limites de l’enfance, ce qui risquerait d’enfermer le sujet dans une trajectoire prégénitale alors que le potentiel « périnévrotique » de l’organisation psychique est patent ?
Sinc Nyström Method for Singularly Perturbed Love's Integral Equation
Authors: Lin Fu-Rong , Lu Xin , Jin Xiao-Qing 
Published: March 2013

AbstractAn efficient numerical method is proposed for the solution of Love's integral equationwhere c > 0 is a small parameter, by using a sinc Nyström method based on a double exponential transformation. The method is derived using the property that the solution ƒ(x) of Love's integral equation satisfies ƒ (x) → 0.5 for x ∈ (−1, 1) when the parameter c → 0. Numerical results show that the proposed method is very efficient.
Antibacterial activity of oregano and sage plant extracts against decarboxylase-positive enterococci isolated from rabbit meat
Authors: Szabóová Renata , Lauková Andrea , Chrastinová Ľubica 
Published: March 2013

The effect of plant extracts (sage, oregano) against decarboxylase-positive enterococci from rabbit back limb meat was reported in this study. Oregano plant extract inhibited the growth of all 34 tested enterococci (the inhibitory zones: 12 to 45 mm). The growth of the majority of strains (n=23) was inhibited by oregano plant extract (the high size inhibitory zones (higher than 25 mm). The growth of 11 strains was inhibited by oregano extract reaching medium size inhibitory zones (10 to 25mm). The most sensitive strain to oregano extract was E. faecium M7bA (45 mm). Sage extract was less active against tested enterococci (n=16) reaching lower inhibitory zones (up to 10 mm).
Utility and Diagnostic Accuracy of Ureteroscopic Biopsy in Upper Tract Urothelial Carcinoma
Authors: Vashistha Vishal , Shabsigh Ahmad , Zynger Debra L. 
Published: March 2013

Context.—Ureteroscopic biopsy is the gold standard for the histopathologic diagnosis of urothelial carcinoma of the upper urinary tract.
Objective.—To assess the accuracy of endoscopically obtained biopsy samples in diagnosing, grading, and staging urothelial carcinoma and correlate diagnostic findings to biopsy sample size.
Design.—We retrospectively reviewed endoscopic biopsies of the ureter, renal pelvis, and ureteropelvic junction from 2008 to 2011. Biopsy diagnoses that were discordant with follow-up pathology and/or ureteroscopic impression were rereviewed and samples were immunohistochemically analyzed.
Results.—Endoscopic biopsies (n = 118) yielded a sensitivity of 85.4% for the ureter (n = 79), 77.8% for the renal pelvis (n = 37), and 100% for the ureteropelvic junction (n = 2). A specificity of 100% for all locations and a diagnostic accuracy of 98.3% were identified. The median sample size was 0.3 cm for true positives, 0.3 cm for true negatives, and 0.2 cm for false negatives with no statistical significance. We found that 87.1% of tumors diagnosed on biopsy had concordant grade and 60.0% had concordant pT stage with follow-up surgical resections (n = 43) and biopsies (n = 24). Biopsy samples with concordant tumor grades (mean = 0.6 cm) compared with follow-up resection were larger than biopsy samples with discordant grades (mean = 0.3 cm) (P = .04).
Conclusions.—Though highly specific, endoscopic biopsy does provide a significant false-negative rate owing to both sampling and diagnostic errors when assessing the upper urinary tract for urothelial carcinoma. Tumor grading is accurate, particularly with larger tissue samples, but tumor staging is unreliable.
A Guide to Understanding and Implementing Risk Evaluation and Mitigation Strategies in Organ Transplantation
Authors: Gabardi Steven , Tichy Eric M. 
Published: March 2013

Objective To review the components of the Congressional mandate for risk evaluation and mitigation strategies (REMS) managed by the Food and Drug Administration and assess their impact on health care providers practicing within the organ transplant arena. Data Sources and Extraction A non-date-limited search of MEDLINE and EMBASE (January 2007-June 2012) was conducted by using the following search terms: risk evaluation and mitigation strategies, REMS, and organ transplant, including a query of the individual organs. Information from the Federal Register and the Food and Drug Administration was also evaluated. Data Synthesis REMS are strategies implemented to manage known or potential risks associated with medications and to ensure ongoing pharmacovigilance throughout the life of a pharmaceutical product. Elements of REMS programs may consist of 3 levels: a medication guide, communication plan, and elements to assure safe use. A medication guide is used to help prevent serious adverse events, aid in patients' decision making, and enhance medication adherence. Communication plans help educate health care providers and encourage adherence with REMS. The elements to assure safe use is a restrictive process implemented when it is deemed necessary to ensure safe access for patients to products with known serious risks. In transplant medicine, REMS currently exist for belatacept (medication guide and communication plan) and the mycophenolic acid derivatives (medication guide and elements to assure safe use). Conclusion REMS are another step in the evolution of the development and marketing of pharmaceutical agents. Use of REMS in solid-organ transplant is becoming common. Transplant clinicians must provide required patient education and become involved with other aspects of REMS implementation to reduce the serious risks of pharmaceuticals and to improve patients' outcomes.