bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higgs portal dark matter freeze-in at stronger coupling: observational benchmarks
Authors: Arcadi Giorgio , Costa Francesco , Goudelis Andreas , Lebedev Oleg 
Published: July 2024

Abstract
We study freeze-in production of Higgs portal dark matter (DM) at temperatures far below the dark matter mass. The temperature of the Standard Model (SM) thermal bath may have never been high such that dark matter production via thermal emission has been Boltzmann-suppressed. This allows for a significant coupling between the Higgs field and DM, which is being probed by the direct DM detection experiments and invisible Higgs decay searches at the LHC. We delineate the corresponding parameter space in the Higgs portal framework with dark matter of spin 0, 1/2 and 1.
Diffusion-weighted imaging in addition to contrast-enhanced MRI in identifying complete response in HER2-positive breast cancer
Authors: van der Voort Anna , van der Hoogt Kay J. J. , Wessels Ronni , Schipper Robert-Jan , Wesseling Jelle , Sonke Gabe S. , Mann Ritse M. 
Published: July 2024

Abstract
Objectives
The aim of this study is to investigate the added value of diffusion-weighted imaging (DWI) to dynamic-contrast enhanced (DCE)-MRI to identify a pathological complete response (pCR) in patients with HER2-positive breast cancer and radiological complete response (rCR).

Materials and methods
This is a single-center observational study of 102 patients with stage I-III HER2-positive breast cancer and real-world documented rCR on DCE-MRI. Patients were treated between 2015 and 2019. Both 1.5 T/3.0 T single-shot diffusion-weighted echo-planar sequence were used. Post neoadjuvant systemic treatment (NST) diffusion-weighted images were reviewed by two readers for visual evaluation and ADCmean. Discordant cases were resolved in a consensus meeting. pCR of the breast (ypT0/is) was used to calculate the negative predictive value (NPV). Breast pCR-percentages were tested with Fisher’s exact test. ADCmean and ∆ADCmean(%) for patients with and without pCR were compared using a Mann-Whitney U-test.

Results
The NPV for DWI added to DCE is 86% compared to 87% for DCE alone in hormone receptor (HR)-/HER2-positive and 67% compared to 64% in HR-positive/HER2-positive breast cancer. Twenty-seven of 39 non-rCR DWI cases were false positives. In HR-positive/HER2-positive breast cancer the NPV for DCE MRI differs between MRI field strength (1.5 T: 50% vs. 3 T: 81% [p = 0.02]). ADCmean at baseline, post-NST, and ∆ADCmean were similar between patients with and without pCR.

Conclusion
DWI has no clinically relevant effect on the NPV of DCE alone to identify a pCR in early HER2-positive breast cancer. The added value of DWI in HR-positive/HER2-positive breast cancer should be further investigated taken MRI field strength into account.

Clinical relevance statement
The residual signal on DWI after neoadjuvant systemic therapy in cases with early HER2-positive breast cancer and no residual pathologic enhancement on DCE-MRI breast should not (yet) be considered in assessing a complete radiologic response.

Key Points

Radiologic complete response is associated with a pathologic complete response (pCR) in HER2+ breast cancer but further improvement is warranted.

No relevant increase in negative predictive value was observed when DWI was added to DCE.

Residual signal on DW-images without pathologic enhancement on DCE-MRI, does not indicate a lower chance of pCR.
Transparent maltitol- cellulose nanocrystal film for high performance barrier
Authors: Nasiri Naghmeh , Cainglet Hans Estrella , Garnier Gil , Batchelor Warren 
Published: July 2024

AbstractThe broad applications of cellulose nanocrystal (CNC) films are restricted by their low resistance against water and brittleness. In this study, high barrier transparent films composed of CNCs and maltitol, used as a bio-plasticizer (at up to 30% weight), were prepared by spray deposition. Addition of plasticizer increased the optical transmittance of the films. It also improved elongation at break and flexibility of the films, while reducing Young’s modulus and tensile strength. The barrier properties of CNC films plasticized with maltitol were significantly improved over CNC. In particular, films containing 30 wt.% maltitol showed a water vapor permeability of 3.67 × 10–12 (g/Pa.s.m) and oxygen permeability of 4.75 (cm3.µm/m2.day.Pa) corresponding to 94% and 78% reductions over CNC films, respectively. This remarkable barrier improvement is attributed to a combination of decreased porosity and the interaction of hydroxy groups of maltitol and CNCs. This interaction led to a reduction of the free hydroxy groups available to interact with the water molecules diffusing in the nanocomposite films, as confirmed by dynamic vapor sorption measurements. This study presents maltitol as a green plasticizer significantly improving the CNC film properties and enabling new barrier applications.
3D wave dispersion analysis of graphene platelet-reinforced ultra-stiff double functionally graded nanocomposite sandwich plates with metamaterial honeycomb core layer
Authors: Aktaş Kerim Gökhan 
Published: July 2024

AbstractThis research addresses the three-dimensional thermomechanical wave propagation behavior in sandwich composite nanoplates with a metamaterial honeycomb core layer and double functionally graded (FG) ultra-stiff surface layers. Due to its potential for high-temperature applications, pure nickel (Ni) is preferred for the honeycomb core layer, and an Al2O3/Ni ceramic-metal matrix is preferred for the surface layers. The functional distribution of graphene platelets (GPLs) in three different patterns, Type-U, Type-X, and Type-O, in the metal-ceramic matrix with a power law distribution provides double-FG properties to the surface layers. The mechanical and thermal material characteristics of the core and surface layers, as well as the reinforcing GPLs, are temperature-dependent. The pattern of temperature variation over the plate thickness is considered to be nonlinear. The sandwich nanoplate’s motion equations are obtained by combining the sinusoidal higher-order shear deformation theory (SHSDT) with nonlocal integral elasticity and strain gradient elasticity theories. The wave equations are established by using Hamilton’s principle. Parametric simulations and graphical representations are performed to analyze the effects of honeycomb size variables, wave number, the power law index, the GPL distribution pattern, the GPL weight ratio, and the temperature rise on three-dimensional wave propagation in an ultra-stiff sandwich plate. The results of the analysis reveal that the 3D wave propagation of the sandwich nanoplate can be significantly modified or tuned depending on the desired parameters and conditions. Thus, the proposed sandwich structure is expected to provide essential contributions to radar/sonar stealth applications in air, space, and submarine vehicles in high or low-temperature environments, protection of microelectromechanical devices from high noise and vibration, soft robotics applications, and wearable health and protective equipment applications.
Cost avoidance of pharmacist-led deprescribing using STOPPFrail for older adults in nursing homes
Authors: Hurley Eoin , Byrne Stephen , Walsh Elaine , Foley Tony , Woods Noel , Dalton Kieran 
Published: July 2024

Abstract
Background
The Screening Tool of Older Persons Prescriptions in Frail adults with limited life expectancy (STOPPFrail) criteria aim to reduce inappropriate/unnecessary medications in frail older adults, which should minimise adverse drug events and additional healthcare expenditure. Little is known about the economic outcomes of applying these criteria as an intervention.

Aim
To evaluate cost avoidance of pharmacist-led application of STOPPFrail to frail older nursing home residents with limited life expectancy.

Method
Pharmacist-identified STOPPFrail-defined potentially inappropriate medications that were deprescribed by patients’ general practitioners were assigned a rating by a multidisciplinary panel, i.e. the probability of an adverse drug event occurring if the medication was not deprescribed. The intervention’s net cost benefit and cost–benefit ratio were then determined by factoring in adverse drug event cost avoidance (calculated from probability of adverse drug event ratings), direct cost savings (deprescribed medication costs/reimbursement fees), and healthcare professionals’ salaries.

Results
Of the 176 potentially inappropriate medications deprescribed across 69 patients, 65 (36.9%) were rated as having a medium or high probability of an adverse drug event occurring if not deprescribed. With €27,162 for direct cost savings, €61,336 for adverse drug event cost avoidance, and €2,589 for healthcare professionals' salary costs, there was a net cost benefit of €85,909 overall. The cost–benefit ratio was 33.2 and remained positive in all scenarios in sensitivity analyses.

Conclusion
Pharmacist-led application of STOPPFrail to frail older nursing home residents is associated with significant cost avoidance. Wider implementation of pharmacist interventions in frail older nursing home residents should be considered to reduce potentially inappropriate medications and patient harm, alongside substantial cost savings for healthcare systems.
Exploring the transition: biology, technology, and epistemic activities
Authors: Tamborini Marco 
Published: July 2024

AbstractBy focusing on biorobotics, this article explores the epistemological foundations necessary to support the transition from biological models to technological artifacts. To address this transition, I analyze the position of the German philosopher Thomas Fuchs, who represents one possible approach to the problem of the relationship between bio-inspired technology and biology. While Fuchs defends the idea of a unique ontological space for humans, this article contends that his categorical distinctions face challenges in establishing a robust epistemic foundation necessary to ground the transition from biology to technology. After identifying at least three interwoven reasons for rejecting Fuchs’ epistemic foundation, I ask how, through what methods, and by means of which practices the newly bio-inspired object is accessed and shaped. Expanding on philosophy of science and technology in practice, I argue that the plurality of answers to this question provides a possible epistemological foundation within the different frameworks of practices that produce the bio-inspired object. In addressing the potential epistemological foundation for pluralistically grounding the transition from biological models to technological ones, my approach helps us: (i) concretize and examine the relationship between biological and technological models, and (ii) investigate the features and validity of bio-inspired objects, effectively offering a more concrete and pluralistic picture of what bio-inspired sciences and technologies are and what they can (or cannot) do.
The Role of the Neural Exposome as a Novel Strategy to Identify and Mitigate Health Inequities in Alzheimer’s Disease and Related Dementias
Authors: Granov Ravid , Vedad Skyler , Wang Shu-Han , Durham Andrea , Shah Divyash , Pasinetti Giulio Maria 
Published: July 2024

AbstractWith the continuous increase of the elderly population, there is an urgency to understand and develop relevant treatments for Alzheimer’s disease and related dementias (ADRD). In tandem with this, the prevalence of health inequities continues to rise as disadvantaged communities fail to be included in mainstream research. The neural exposome poses as a relevant mechanistic approach and tool for investigating ADRD onset, progression, and pathology as it accounts for several different factors: exogenous, endogenous, and behavioral. Consequently, through the neural exposome, health inequities can be addressed in ADRD research. In this paper, we address how the neural exposome relates to ADRD by contributing to the discourse through defining how the neural exposome can be developed as a tool in accordance with machine learning. Through this, machine learning can allow for developing a greater insight into the application of transferring and making sense of experimental mouse models exposed to health inequities and potentially relate it to humans. The overall goal moving beyond this paper is to define a multitude of potential factors that can increase the risk of ADRD onset and integrate them to create an interdisciplinary approach to the study of ADRD and subsequently translate the findings to clinical research.
Unlocking wear resistance in an ultrastrong dual-phase high-entropy alloy by interface-constrained deformation of brittle Laves phases
Authors: Liang Fei , Sun Yixing , Wan Hongyuan , Li Yong , Lu Wenhao , Meng Ao , Gu Lei , Luo Zhaoping , Lin Yan , Zhang Yaping , Chen Xiang 
Published: July 2024

AbstractThe pronounced brittleness of hard Laves phase intermetallics is detrimental to their tribological properties at room temperature. In this study, we utilized a heterogeneous structure to engineer an ultrastrong dual-phase (Laves + B2) AlCoFeNiNb high-entropy alloy that exhibits a low wear rate (3.82×10−6 mm3/(N·m)) at room temperature. This wear resistance in the ball-on-disc sliding friction test with the counterpart of Al2O3 balls stems from the activated deformation ability in the ultrafine Laves lamellae under heterogeneous interface constraints. Furthermore, as tribological stress intensifies, the surface deformation mechanism transitions from dislocation slip on the basal and pyramidal planes to a unique combination of local shear and grain rotation within the Laves phase. Our study illuminates fresh perspectives for mitigating the embrittling effect of Laves phase intermetallics under tribological loading and for the development of wear-resistant materials.
Cleaning and coating procedures determine biological properties of gyroid porous titanium implants
Authors: Depboylu Fatma Nur , Taşkonak Beliz , Korkusuz Petek , Yasa Evren , Ajiteru Olatunji , Choi Kyu Young , Park Chan Hum , Poyraz Özgür , Popa Andrei-Alexandru , Korkusuz Feza 
Published: July 2024

AbstractCleaning and coating processes as well as biocompatibility of gyroid commercially pure titanium (Cp-Ti) biomedical implants using the laser powder bed fusion (L-PBF) technology were analyzed. Etching time for cleaning of gyroid Cp-Ti biomedical implants were determined to remove non-melted particles from the surface. Nano hydroxyapatite (nHA) and polylactic acid (PLA) composite coating on the gyroid Cp-Ti implants via dip coating were optimized. Dip coating’s withdrawal speed also, the amount of nHA:PLA and viscosity effects of composite were evaluated. 1000 mm/min withdrawal speed prevented clogging of the pores. In addition, silk fibroin was coated on gyroid Cp-Ti implants with electro deposition method. Optimum coating thicknesses were achieved. Biocompatibility after PLA:nHA and silk fibroin were studied. Gyroid and solid Cp-Ti presented 3% and 1% mass loss after a minute of HF/HNO3 etching. The three-minute etching protocol led to the highest micro pit width formation on the surfaces. 70:30 PLA:nHA and silk fibroin established crack-free coatings on gyroid Cp-Ti surfaces. MTT, live-dead cell assay revealed good biocompatibility after coating.
Chatter Identification on a Mobile Milling Machine: Experimental Insights Using Low-frequency Internal Sensors
Authors: Rowe James , Langrand Christopher , MASSET Maxime , Debarre Etienne , Delahaye Nicolas , Deprez Pascal , Debuchy Roger 
Published: July 2024

Abstract
Introduction
On-site milling with mobile machine tools is a popular solution for the modification of large or immobile metal parts. For such operations the transportation and setup of the machine constitutes a delicate process. Hence, mobile machine designs must find a good compromise between power, structural rigidity, and adaptability. However, this compromise can lead to flexible structures which are susceptible to chatter.

Materials and methods
The present article is dedicated to chatter identification in a numerically controlled mobile milling machine using low-frequency internal sensors. This solution is low-cost and removes the need for further sensor installation during on-site operations. Milling operations are carried out for a wide range of parameters and chatter is diagnosed using a high-frequency accelerometer. Then, time domain statistical features on the internal sensor signals are computed to evaluate their potential for chatter identification. Two strategies for chatter classification are tested: firstly, using an empirically determined threshold on the features, and, secondly, using Support Vector Machine (SVM).

Results
Using the linear thresholding technique, maximum agreement between the accelerometer classification and the internal sensor classification is 91 % for chatter and non chatter data. However, using the C-SVM method, classification was improved up to a 98 % agreement for the chatter cases and a 95 % agreement for the non-chatter cases.

Conclusion
Thus the authors conclude that using a C-SVM classification method allows accurate chatter detection in the mobile milling machine using internal sensor data.
Mitigating Combined Boron and Salt Stress in Lettuce (Lactuca Sativa L. Semental) through Salicylic Acid-Modified Rice Husk Biochar
Authors: Sahin Ozge , Gunes Aydin , Yagcıoglu Kiymet Deniz , Kadioglu Yusuf Kagan 
Published: July 2024

AbstractPurpose: This study thoroughly investigates innovative amendment salicylic acid (SA) modified rice husk biochar (SABC) designed to improve boron (B) and salinity tolerance in lettuce, providing a comprehensive exploration of their potential effects in alleviating stress-induced challenges. Methods: Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopy were used for the molecular and chemical characterization of the biochar samples. The treatments consisted of control, 40 mM NaCl plus 20 mg B kg-1 (NaCl + B), and 40 mM NaCl plus 20 mg B kg-1 and 5 g kg-1 SA-modified rice husk biochar (NaCl + B + SABC). Results: Under conditions of salt and B toxicity, SABC treatment significantly prevented the decrease in plant weight induced by stress. SABC reduced the concentrations of B, sodium (Na), and chloride (Cl) in plants, while increasing the concentrations of potassium (K) and silicon (Si). The hydrogen peroxide concentration, which increased as a result of B and salt toxicity, was decreased with SABC. The activities of the antioxidant enzymes superoxide dismutase (SOD) and ascorbate peroxidase (APX) showed a significant increase under stress, but due to the positive effect of SABC in reducing B and salt stress, there was a decrease in the activities of these enzymes. Conclusions: The results obtained from this study indicate that SABC is effective in reducing boron and salt stress. Testing the SABC molecule in different plants and under various stress conditions could provide significant contributions to the stress literature.
Investigation of in vitro biological activity of young Hordeum vulgare leaf in correlation with its bioactive compounds
Authors: Lantos Ferenc , Váczi Vivien , Gyalai Ingrid , Süli-Zakar Tímea , Szarvas Adrienn , Tar Melinda , Püski Péter , Bajtel Ákos , Kiss Tivadar 
Published: July 2024

AbstractYoung shoots of cereals are widely regarded as superfoods with health benefits attributed to their potential antioxidant activity and antioxidant-related effects (e.g. anticancer). The current study aimed to examine the chemical characteristics of Hordeum vulgare methanolic and aqueous extracts and assess their antioxidant activity using the DDPH and ORAC. Furthermore, the inhibitory effect of xanthine oxidase was screened. TLC bioautography was employed to determine the polarity of the compounds present in the extracts that exhibited the most potent free radical scavenging activity. Total flavonoid content of the methanolic and aqueous extracts was 0.14 mg QE/g and 0.012 mg QE/g, respectively. The antioxidant activity of the methanolic extract was found to be more potent, with a value of 0.97 ± 0.13 mmol TE/g than the aqueous extract which had no activity. This study presents novel findings on the xanthine inhibitory activity of H. vulgare. The methanolic extract demonstrated moderate inhibition of xanthine oxidase with a value of 23.24%. The results of our study were compared with the phytochemical and pharmacological analysis of Triticum aestivum, and further comparison was made with the data reported in the literature. Inconsistencies were observed in the chemical and pharmacological properties of H. vulgare, which could be a result of using herbal material harvested in different vegetative phases and various methods used for extraction. The findings of our study indicate that the timing of the harvest and extraction method may play crucial role in attaining the optimal phytochemical composition of H. vulgare, hence enhancing its pharmacological activity.
Evaluation of the effect of E-waste on the permeability properties of polymer concrete composites and their behavior in aggressive environments
Authors: Aydın Merve , Bulut H. Alperen 
Published: July 2024

AbstractThe rapid increase in the number of electronic products worldwide, in terms of both variety and advanced technology, together with the decrease in costs, has led to the generation of a large amount of electronic waste (e-waste), which has significantly increased environmental pollution. This study was conducted to investigate the hypothesis that the adhesion of polymer binders and plastic origin e-waste will be more effective and stronger, and therefore have a positive effect on the permeability properties of polymer concrete and its behavior against aggressive solutions. For this purpose, quartz aggregates and gravel used as an aggregate in polymer concrete were replaced with 0%, 3%, 6%, 9%, 12% and 15% e-waste. In the study where unsaturated polyester resin was used as a binder, the changes in the permeability properties (capillary water absorption, rapid chloride permeability) of the e-waste polymer concrete and its behavior against aggressive solutions (acid and sulfate attacks) were evaluated after 7, 28 and 90 days. In addition, mechanical experiments were conducted and comparisons were made. After the control concrete, the highest compressive strengths were obtained from the polymer concrete specimens using 3% e-waste, measured as 59.05 MPa, 64.5 MPa and 73.05 MPa after 7, 28 and 90 days, respectively. The research showed that polymer concretes with capillary water absorption coefficient values close to zero after 90 days can be produced with using up to 9% e-waste. The use of e-waste as an aggregate in polymer concrete at 3%, 6% and 9% e-waste, in particular, produced concrete with a high resistance to acid and sulfate attacks. The hypothesis of the study was confirmed after extensive experiments.
Graphical Abstract