bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proliferative effect and osteoinductive potential of extracellular matrix coated on cell culture plates
Authors: Guo Yong , Zeng Qiangchen , Yan Yuxian , Shen Liang , Liu Lu , Li Ruixin , Zhang Xizheng , Wu Jimin , Guan Jing , Huang Shujie 
Published: July 2013

Abstract
Different cell/tissue derived extracellular matrix (ECM) display subtle differences that might provide important cues for proliferation and differentiation of cells in vitro or in vivo. However, the bioactivities of different ECMs in vitro were not fully understood. In this study, osteoblasts-derived and fibroblast-derived ECM-coated cell culture dishes were prepared respectively by culturing osteoblastic MC3T3-E1 cells and rat fibroblast then decellularizing the cultures. We investigated the bioactivities of the two different ECMs coated on cell culture plates using cellular, biochemical and molecular method. The proliferative activity of the bone marrow-derived mesenchymal stem cells (BMSCs) cultured on osteoblast-ECM was lower than for BMSCs grown on fibroblast-ECM. Compared with the BMSCs cultured on fibroblast-derived ECM, the cells grown on osteoblastic ECM showed enhanced alkaline phosphatase (ALP) activity, higher BMP-2 and osteopontin protein levels, increased secreted calcium content, and higher levels of runt-related transcriptional factor 2 (Runx 2) and osteocalcin (OCN) mRNA. Knockdown of BMP-2 or FGF-2 with shRNA transfection hardly effected osteoblastic differentiation or proliferation of MC3T3-E1 seeded on osteoblast-ECM or fibroblast-ECM. Therefore, the osteoblastic ECM had better osteoinductive potential and lower proliferative effect than fibroblastic ECM, and the two ECM presented enough bioactivity, knockdown of growth factors had no significant effect on differentiation and proliferation of re-seeded cells.
Photo and Thermal Control of Liposome Solubilization
Authors: Igarashi Takashi , Kuwahara Shota , Katayama Kenji 
Published: July 2013

Abstract
The solubilization of liposomes induced by the addition of surfactants was photocontrolled under temperature control. The instability of the membrane was increased both by photoisomerization of photoresponsive molecules included in the membrane and by changing temperature. By addition of a spiropyran to the liposome membrane, charge-separated structure was formed by UV irradiation, causing local polarization and subsequent motion in the membrane. We found a difference in the solubilization processes in a specific temperature range under UV irradiated and nonirradiated conditions, and figured out that the solubilization of liposomes smaller than 2 µm can be distinctly photocontrolled in a certain temperature range.
Universality of Molten State of Alkyl Chain in Liquid-Crystalline Mesophases: Smectic E Phase of 6-Alkyl-2-phenylazulene
Authors: Adachi Takuya , Saitoh Hideki , Yamamura Yasuhisa , Hishida Mafumi , Ueda Mao , Ito Shunji , Saito Kazuya 
Published: July 2013

Abstract
Through thermodynamic, spectroscopic, and structural studies, the molten state of the alkyl chain in SmE phase, which is the liquid-crystalline mesophase closest to an ordered crystalline phase, has been established in a calamitic mesogen nPA. Combining the same conclusion for the SmE phase of another calamitic mesogen nTCB, it is concluded that the alkyl chain attached at end(s) of a rod-like core is molten in any liquid-crystalline mesophase. The thermodynamic implications are briefly discussed.
Institutions and information in multilateral bargaining experiments
Authors: Shupp Robert , Cadigan John , Schmitt Pamela M. , Swope Kurtis J. 
Published: July 2013

AbstractThis paper examines the behavior in multilateral bargaining experiments with alternating offers and asymmetric information. In all experiments, a single buyer has up to ten bargaining periods to purchase one unit of a good from each of two sellers. Treatments vary based on who makes the first offer (buyer or sellers), timing (consistent buyer-offer/sellers-demand or alternating), and information (buyer’s value and sellers’ costs are known or come from a uniform distribution). We find that actual bargaining outcomes are virtually identical when offers alternate, regardless of which player makes the first offer. We find that alternating offers reduce bargaining delay slightly compared to treatments in which one side or the other makes repeated take-it-or-leave-it offers. Finally, we find that incomplete information increases bargaining delay and the likelihood of failed agreements.
Syphilis Cycles
Authors: Aadland David , Finnoff David C. , Huang Kevin X.D. 
Published: July 2013

AbstractSyphilis has re-emerged as a global public health issue. In lesser developed countries, millions of people are contracting the disease, which can be fatal without access to proper treatment. In developed countries, prevalence is on the rise and has cycled around endemic levels for decades. We investigate syphilis dynamics by extending the classic SIRS epidemiological model to incorporate forward-looking, rational individuals. The integrated economic-epidemiological model shows that human preferences over health and sexual activity are central to the nature of syphilis cycles. We find that low-activity individuals will behave in a manner that significantly dampen the cycles, while high-activity individuals will tend to exacerbate the cycles, a phenomenon we refer to asrational dynamic resonance. The model also provides insights into failed attempts by the U.S. government to eradicate syphilis from the U.S. population.
Informal Care and Inter-vivos Transfers: Results from the National Longitudinal Survey of Mature Women
Authors: Norton Edward C. , Nicholas Lauren H. , Huang Sean Sheng-Hsiu 
Published: July 2013

Abstract
Informal care is the largest source of long-term care for elderly, surpassing home health care and nursing home care. By definition, informal care is unpaid. It remains a puzzle why so many adult children give freely of their time. Transfers of time to the older generation may be balanced by financial transfers going to the younger generation. This leads to the question of whether informal care and inter-vivos transfers are causally related. We analyze data from the 1999 and 2003 waves of National Longitudinal Survey of Mature Women. We examine whether the elderly parents give more inter-vivos monetary transfers to adult children who provide informal care, by examining both the extensive and intensive margins of financial transfers and of informal care. We find statistically significant results that a child who provides informal care is more likely to receive inter-vivos transfers than a sibling who does not. If a child does provide care, there is no statistically significant effect on the amount of the transfer.
Effects of the Endogenous Scope of Preferentialism on International Goods Trade
Authors: Egger Peter , Wamser Georg 
Published: July 2013

Abstract
Previous empirical research has assumed that goods trade responds to goods trade preferentialism only, while other forms of preferentialism — such as services trade or investment preferentialism — are irrelevant for goods trade. This article provides novel evidence for the gains from a broader scope of preferentialism (in terms of the number of dimensions covered: goods, services, and investment) at the intensive and extensive country margins of bilateral goods trade.
Molecular insights into type I secretion systems
Authors: Lenders Michael H.H. , Reimann Sven , Smits Sander H. J. , Schmitt Lutz 
Published: July 2013

Abstract
Type 1 secretion systems are one of the main machineries in Gram-negative bacteria involved in the secretion of a wide range of substrates from the cytoplasm across the inner and outer membrane in one step to the extracellular space. The range of substrates varies from small proteins up to large surface layer proteins of about 900 kDa. Most of the substrates have a non-cleavable C-terminal secretion signal and so-called GG repeats that are able to bind calcium ions. The translocator complex is composed of a trimeric outer membrane protein that provides a pore in the outer membrane. A multimeric membrane fusion protein spans the periplasm and forms a continuous channel connecting the outer membrane protein with a dimeric ATP-binding cassette transporter in the inner membrane. The ATP-binding cassette-transporter is thought to form a channel through the inner membrane and energizes the transport process. This review will provide a detailed view of the components of the translocator and will summarize structural as well as functional data.
Revisiting Disrupted-in-Schizophrenia 1 as a scaffold protein
Authors: Yerabham Antony S.K. , Weiergräber Oliver H. , Bradshaw Nicholas J. , Korth Carsten 
Published: July 2013

Abstract

Disrupted-in-Schizophrenia 1 (DISC1) is a widely-accepted genetic risk factor for schizophrenia and many other major mental illnesses. Traditionally DISC1 has been referred to as a ‘scaffold protein’ because of its ability to bind to a wide array of other proteins, including those of importance for neurodevelopment. Here, we review the characteristic properties shared between established scaffold proteins and DISC1. We find DISC1 to have many, but not all, of the characteristics of a scaffold protein, as it affects a considerable number of different, but related, signaling pathways, in most cases through inhibition of key enzymes. Using threading algorithms, the C-terminal portion of DISC1 could be mapped to extended helical structures, yet it may not closely resemble any of the known tertiary folds. While not completely fitting the classification of a classical scaffold protein, DISC1 does appear to be a tightly regulated and multi-faceted inhibitor of a wide range of enzymes from interrelated signaling cascades (Diverse Inhibitor of Signaling Cascades), which together contribute to neurodevelopment and synaptic homeostasis. Consequently, disruption of this complex regulation would be expected to lead to the range of major mental illnesses in which the DISC1 gene has been implicated.
Deformation Mechanisms of Tandem Hot Rolled GH4169 Superalloy during Creep
Authors: Li Zhenrong , Ma Chunlei , Tian Sugui , Chen Liqing , Liu Xianghua 
Published: July 2013

AbstractBy means of direct aged treatment, creep property measurement and high resolution TEM microstructure observation, the deformation mechanisms of Tandem Hot Rolled GH4169 superalloy during creep are investigated. Results show that, after direct aging treatment, fine γ″ particles with different sizes and shapes dispersedly precipitate in the alloy, which is one of important factors for the alloy possessing good creep resistance. And the deformation mechanisms of the alloy are that the deformed twinnings with different orientations are activated on {111} plane by pole mechanism, thereinto, the twinning dislocation may continuously slip around a pole axis dislocation on the twinning planes when the applied stress exceeds the critical value, and the twinnings may multiply by the dislocation reactions and mutual indemnification. As creep goes on, the denser dislocations with single or double orientations slip in the different twinnings, which play an important role of coordinating the grain deformation to enhance the creep resistance of the alloy.
A systematic review of transition readiness and transfer satisfaction measures for adolescents with chronic illness
Authors: Stinson Jennifer , Kohut Sara Ahola , Spiegel Lynn , White Meghan , Gill Navreet , Colbourne Gina , Sigurdson Samantha , Duffy Karen Watanabe , Tucker Lori , Stringer Elizabeth , Hazel Beth , Hochman Jacqueline , Reiss John , Kaufman Miriam 
Published: July 2013

AbstractBackground:The transition from pediatric to adult health care can be challenging for adolescents with chronic illnesses. As a result, many adolescents are unable to transfer to adult health care successfully. Adequate measurement of transition readiness and transfer satisfaction with disease management is necessary in order to determine areas to target for intervention towards improving transfer outcomes.Objectives:This study aims to systematically review and critically appraise research on transition readiness and transfer satisfaction measures for adolescents with chronic illnesses as well as to assess the psychometric quality of these measures.Methods:Electronic searches were conducted in MEDLINE, EMBASE, CINAHL, PsychINFO, ERIC, and ISI Web of Knowledge for transition readiness and transfer satisfaction measures for adolescents with chronic health conditions. Two reviewers independently selected articles for review and assessed methodological quality.Results:In all, eight readiness and six satisfaction measures met the inclusion criteria, for a total of 14 studies, which were included in the final analysis. None of these measures have well-established evidence of reliability and validity. Most of the measures were developed ad hoc by the study investigators, with minimal to no evidence of reliability and/or validity using the Cohen criteria and COSMIN checklist.Conclusion:This research indicates a major gap in our knowledge of transitional care in this population, because there is currently no well-validated questionnaire that measures readiness for transfer to adult health care. Future research must focus on the development of well-validated transition readiness questionnaires, the validation of existing measures, and reaching consensus on outcomes of successful transfer.
A Novel Reactor for Microwave Hydrothermal Scale-up Nanopowder Synthesis
Authors: Majcher Andrzej , Wiejak Jan , Przybylski Jan , Chudoba Tadeusz , Wojnarowicz Jacek 
Published: July 2013

Abstract
The article presents a novel microwave reactor for hydrothermal synthesis of nanopowders. The reactor has a unique design of a process chamber, which, when used in conjunction with a batch control system, allows a highly efficient production of nanopowders. The design of the reactor together with the new principles of operation, structural materials and distribution of electromagnetic field are described. The article also presents a control system for the reactor, which allows for an automatic operation in the stop–flow mode, control of process pressure, continuous monitoring of process parameters and safe operation of the device. The device verification process is shown on the basis of the results of cobalt-doped zinc oxide nanopowder synthesis.
Modeling and Simulation of a Fischer–Tropsch Slurry Bubble Column Reactor Using Different Kinetic Rate Expressions for Iron and Cobalt Catalysts
Authors: Sehabiague Laurent , Morsi Badie I. 
Published: July 2013

Abstract
A user-friendly simulator based on a comprehensive computer model for slurry bubble column reactor (SBCR) was used to predict the performance of a conceptual commercial-scale (9-m ID and 50-m height) SBCR for Fischer–Tropsch (F–T) synthesis. Novel correlations for predicting the hydrodynamic and mass transfer parameters; a new relationship between the axial dispersion of large gas bubbles and their average diameter; and up to ten different kinetic rate expressions available in the literature for iron and cobalt-based catalysts were included in the simulator. The effects of operating conditions, including catalyst concentration, pressure, temperature, H2/CO ratio, and superficial gas velocity on the SBCR performance were predicted using the simulator for both types of catalysts. The predictions showed that the performance of the reactor was strongly dependent on the type of catalyst and the kinetic rate expression used.
Mass Transfer and Conservation from a Finite Source to an Infinite Media
Authors: Samimi Abianeh O. , Chen C. P. , Cerro Ramon L. 
Published: July 2013

Abstract
A theoretical/computational approach has been developed to satisfy mass transfer rates and molar fraction constraints simultaneously when modeling mass transfer from a finite source towards an infinite surrounding media. The procedure is based on using a mass balance of individual molecular species coupled with individual mass transfer rates. Since the surrounding media is assumed insoluble in the finite media, the total number of moles transferred across the interface is computed on the basis of modified molar fractions of the transferring species. Two simple examples are shown: the first is an evaporating droplet in air and the second example is a droplet being dissolved in water. These examples have very large differences in time scales and illustrate the versatility and accuracy of the computational procedure.
Production of Amino and Organic Acids from Protein Using Sub-Critical Water Technology
Authors: Abdelmoez Wael , Yoshida Hiroyuki 
Published: July 2013

Abstract
This work presents the hydrolysis of a water-soluble protein, bovine serum albumin (BSA), for the production of both amino and organic acids under the sub-critical water condition in the temperature range of 200–300°C. The products of the reaction were a water-insoluble solid phase, an aqueous phase, and an insignificant gas phase which was neglected in this study. Results have shown that BSA passes through an aggregation step, followed by a gel formation process which results in the formation of insoluble solid aggregates. Then, such formed solids unfolded with releasing polypeptides as an intermediate product then finally hydrolyzed to produce low molecular mass products such as amino and organic acids. It was found that there were insignificant amino acids produced in the temperature ranges of 200–225°C within 2 min and 275–300°C within 0.5 min. However, by extending the reaction time, the protein transferred to both amino and organic acids.
Gamma-irradiated liposome/niosome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis
Authors: Turker Selcan , Yekta Özer A. , Kiliç Ekrem , Özalp Meral , Çolak Seyda , Korkmaz Mustafa 
Published: July 2013

Abstract
Treatment of rheumatoid arthritis by intraarticular administration of anti-inflammatory drugs encapsulated in drug delivery systems, such as liposomes/niosomes and lipogelosomes/niogelosomes, prolongs the residence time of the drugs in the joint. It was therefore anticipated that liposome/niosome entrapment would enhance the efficacy of drugs in the inflammatory sides. Liposomes are good candidates for the local delivery of therapeutic agents, such as diclofenac sodium (DFNa), for intraarticular delivery. Drugs for parenteral delivery must be sterile, and radiation sterilization is a method recognized by pharmacopoeias to achieve sterility of drugs. However, irradiation might also affect the performance of drug delivery systems. One of the most critical points is irradiation dose, because certain undesirable chemical and physical changes may accompany with the treatment, especially with the traditionally applied dose of 25 kGy. The present study aims to determine the effects of gamma irradiation on DFNa-loaded liposomes/niosomes and lipogelosomes/niogelosomes for the treatment of rheumatoid arthritis.
Facile synthesis of hydrodynamic solid lubricant MoS2 from molybdenum trioxide nanorods
Authors: Sibi Malayil Gopalan , Rana Bharat Singh , Konathala Lakshmi Narayana Sivakumar , Thakre Gananath D. , Saran S. , Sinha Anil Kumar 
Published: July 2013

Abstract
Economical Reactive Powder Concrete Cast Using Available Materials in North Sinai, Egypt
Authors: Meleka Nageh N. , Bashandy Alaa A. , Arab Mohamed A. 
Published: July 2013

Abstract In this research reactive powder concrete (RPC) was prepared using sand from North Sinai. The mechanical properties of locally cast RPC were investigated and evaluated by studying the effects of using different cement and silica fume contents and new steel fibers’ aspect ratios as reinforcement for RPC. Specimens’ preparation, curing regimes and testing procedures to evaluate the compressive strength, the modulus of elasticity, the indirect tensile strength and the flexural strength were discussed. A compressive strength of 154.5MPa, indirect tensile strength of 11.98MPa, modulus of elasticity of 45.1GPa and flexural strength of 30.26MPa have been achieved for reinforced RPC contains 800 kg/m3 cement content and silica fume content 30% of cement weight. The test results showed some improvements by increasing cement and silica fume contentsas well as adding steel fibers on the compressive strength, modulus of elasticity and indirect tensile strength.
Evaluation of Probability of Bridge Damage as a Result of Terrorist Attack
Authors: Duchaczek A. , Skorupka D. 
Published: July 2013

Abstract The paper presents an approach for evaluation of the likelihood of damage to the transportation infrastructure in the context of the terrorist attacks on the example of a number of bridges located in Wrocław (Poland). Assuming that there will be only one bridge destroyed in a given area, in order to determine the probability of damage to one of the objects, there was one of multi-criteria optimization methods used, i.e. the method of Analytical Hierarchy Process (AHP). The main advantage of the analysis carried out was that the accepted hierarchy of decision-making options could be easily explained in a scientific manner, not only with reference to personal knowledge, experience, and intuition.
Investigations of Fatigue of Asphalt Layers with Geosynthetics
Authors: Zieliński P. 
Published: July 2013

Abstract This paper presents the results of an extensive investigation of asphalt concrete beams with geosynthetics interlayer. The subject of the research is an evaluation of influence of geosynthetics interlayer applied to bituminous samples on their fatigue life. The results of the tests evidences that when geosynthetics are used, the fatigue life depends mainly on the type of bituminous mixture, the type of geosynthetics, and the type and the amount of bitumen used for saturation and sticking. The amount of bitumen used to saturate and fix the geosynthetic significantly changes the samples fatigue properties. Essential positive correlation between fatigue and parameters of interlayer bonding (shear strength, shear stiffness) occurs in both testing temperatures.
The Investigation of Mercury Contents in Polish Coal Samples
Authors: Wichliński Michał , Kobyłecki Rafał , Bis Zbigniew 
Published: July 2013

Abstract
This paper presents the results of the investigation associated with the determination of mercury content in Polish hard coal and lignite samples. Those coals are major fuels used for electricity generation in Poland. The results indicated that the average content of mercury in the coal samples was roughly about 100 ng/g. Apart from the determination of the mercury contents a detailed ultimate and proximate analysis of the coal samples was also carried out. The relationships between the mercury content and ash, as well as fixed carbon, volatile matter, sulfur, and high heating value of the coal samples were also established. Furthermore, the effect of coal enrichment was also investigated, and it was found that the enrichment process enabled the removal of up to 75% of the coal mercury from the samples.
Biosorption of Pb(II) and Zn(II) by Extracellular Polymeric Substance (Eps) of Rhizobium Radiobacter: Equilibrium, Kinetics and Reuse Studies
Authors: Wang Lili , Yang Jixian , Chen Zhonglin , Liu Xiaowei , Ma Fang 
Published: July 2013

Abstract
The extracellular polymeric substance (EPS) produced from Rhizobium radiobacter F2, designated as EPSF2, was investigated as a biosorbent for the removal of Pb(II) and Zn(II) from aqueous solution. The optimum biosorption pH values were 5.0 for Pb(II) and 6.0 for Zn(II). Kinetics study revealed that the biosorption followed pseudo-first-order model well, and the equilibrium data fit the Langmuir model better. The adsorbed metal ions could be effectively desorbed by HCl. Desrobed EPSF2 regained 80% of the initial biosorption capacity after five cycles of biosorption-desorption-elution. These results demonstrated that EPSF2 could be a promising alternative for Pb(II) and Zn(II) removal from aqueous solution.