bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease
Authors: Clemmer John S. , Pruett W. Andrew , Hester Robert L. 
Published: July 2024

Chronic kidney disease (CKD) is associated with the progressive loss of functional nephrons and hypertension (HTN). Clinical studies demonstrate calcium channel blocker (CCB) therapy mitigates the decline in renal function in humans with essential HTN. However, there are few long-term clinical studies that determine the impact of CCBs in patients with hypertensive CKD. African Americans (AA) have a higher prevalence of CKD and a faster progression to total kidney failure as compared to the white population but the mechanisms are poorly understood. Both clinical evidence (the African American Study of Kidney Disease and Hypertension, or AASK trial) and experimental studies have demonstrated that CCB may expose glomerular capillaries to high systemic pressures and exacerbate CKD progression. Therefore, using a large physiological model, we set out to replicate the AASK trial findings, predict renal hemodynamic responses and the role of the renin-angiotensin system during CCB antihypertensive therapy in a virtual population, and hypothesize mechanisms underlying those findings. Our current mathematical model, HumMod, is comprised of integrated systems that play an integral role in long-term blood pressure (BP) control such as neural, endocrine, circulatory, and renal systems. Parameters (n = 341) that control these systems were randomly varied and resulted in 1,400 unique models that we define as a virtual population. We calibrated these models to individual patient level data from the AASK trial: BP and glomerular filtration rate (GFR) before and after 3 years of amlodipine (10 mg/day). After calibration, the new virtual population (n = 165) was associated with statistically similar BP and GFR before and after CCB. Baseline factors such as elevated single nephron GFR and low tubuloglomerular feedback were correlated with greater declines in renal function and increased glomerulosclerosis after 3 years of CCB. Blocking the renin-angiotensin system (RAS) in the virtual population decreased glomerular pressure, limited glomerular damage, and further decreased BP (−14 ± 8 mmHg) as compared to CCB alone (−11 ± 9 mmHg). Our simulations echo the potential risk of CCB monotherapy in AA CKD patients and support blockade of the renin angiotensin system as a valuable tool in renal disease treatment when combined with CCB therapy.
Veterinary and pet owner perspectives on addressing access to veterinary care and workforce challenges
Authors: Niemiec Rebecca , Champine Veronica , Frey Danielle , Lobdell Allyce , Steele Apryl , Vaiden Claire , Kogan Lori , Mertens Andrew 
Published: July 2024

Objectives(1) Assess and compare the perceptions of pet owners and veterinary professionals pertaining to the extent of veterinary workforce and access to care challenges in 2023 in Colorado, and (2) Assess what programs, policies, and resources veterinary professionals and pet owners believe would be most effective at addressing access to care and workforce challenges in Colorado.Sample736 veterinarians, veterinary technicians, or practice/owner manager (“veterinary professionals”) in Colorado. A total of 1,209 pet owners (919 from an online survey and 290 from in-person surveying).ProceduresDistribution of an online anonymous survey to veterinary professionals in Colorado. Pet owners were surveyed both online and in-person at pet pantry or shelter events.ResultsVeterinary professionals reported significant workforce challenges, including having to frequently divert clients, clients forced to decline medical care or having to euthanize their pets due to cost. Veterinary professionals were especially supportive of policy efforts to enhance recruitment and retention of technicians, including through mechanisms such as clarifying their scope of practice, loan repayment programs, and enhancing career pathways. Colorado pet owners’ responses pertaining to the scope of access to care challenges were similar to prior national research. Pet owners reported particularly needing low-cost emergency clinics in their community as well as resources to reduce the cost of care. Pet owners were generally supportive of expanding veterinary care access through telemedicine; indicating they would feel comfortable seeing a veterinarian via telemedicine, even for the first time, and that expanded use of telemedicine would increase their ability to obtain care.Conclusions and clinical relevanceColorado pet owners and veterinary professionals both identified numerous access to care challenges as well as indicated support for the development of several potential initiatives to address the problem. Low-cost clinics that provide sick and emergency care was the resource rated as being most helpful among pet owners. Further exploration of grants, voucher programs, expansion of telemedicine, increased utilization and title protection for CVTs, and the creation of the veterinary professional associate position are all initiatives that were noted to be worthy of further exploration.
Unraveling the Potential of Saccharum officinarum and Chlorella vulgaris towards 5-Fluorouracil-Induced Nephrotoxicity in Rats
Authors: El-Gendy Hanem F. , El-Bahrawy Amanallah , Mansour Doaa A. , Sheraiba Nagwa I. , Abdel-Megeid Nazema S. , Selim Shaimaa , Alhotan Rashed A. , Ayyoub Anam , El Hanbally Saber 
Published: July 2024

5-Fluorouracil (5-FU) is often used as a chemotherapeutic agent in treating tumors and is said to have adverse effects, including nephrotoxicity. Therefore, the present study aimed to evaluate the protective effects of Chlorella vulgaris (VL) and Saccharum officinarum L. (SOL) against 5-FU-induced nephrotoxicity in rats through the measurement of renal histology, kidney damage indicators, and antioxidant measures. A total of forty-eight male rats were allotted into six groups: group 1 acted as a control negative group (control), group 2 received 5-FU and worked as a control positive group (FU), group 3 received SOL 15 mL/kg (SOL), group 4 received VL 400 mg/kg (VL), group 5 received 5-FU+SOL (5-FU+SOL), and group 6 received 5-FU+VL (5-FU+VL). After fifteen days, blood and renal tissue specimens were collected for hematological, biochemical, molecular, and histopathological examinations. Findings of the current investigation showed that 5-FU leads to hematological alterations and kidney injury evinced by elevated serum concentrations of uric acid, creatinine, and urea (p < 0.01), and a marked increase in kidney MDA and NO levels with a reduction in kidney CAT, SOD and GSH activities (p < 0.05). Alterations of the histopathological structure of kidney tissue in the FU group were noticed compared to the other groups. 5-FU administration elevated expression levels of TNF-α, lipocalin 2, and KIM1 (p < 0.01) compared to the control ones. 5-FU-induced nephrotoxicity was ameliorated after treatment with SOL and VL via their free radical scavenging, potent antioxidant, and anti-inflammatory effects. In conclusion, our findings demonstrate that the treatment with SOL and VL significantly improved nephrotoxicity induced by 5-FU in rats.
EFFICIENCY OF CROSSING CHAROLAIS AND LIMOUSIN BULLS WITH RED STEPPE AND SCHWYZ COWS
Authors: СМАКУЕВ Д.Р. , КУЛИНЦЕВ В.В. , СУРОВ А.И. , ШЕВХУЖЕВ А.Ф. 
Published: July 2024

Одним из эффективных решений в скотоводстве может стать скрещивание бычков мясных пород с коровами комбинированного и молочного направления продуктивности. Исследования проводили в сельхозпредприятии Карачаево-Черкесской Республики. Изучали мясную продуктивность помесей шароле и лимузинов с коровами красной степной и швицкой пород. Установлено, что при рождении помеси с шароле отличались от чистопородных особей на 42—70%, а лимузинов — на 29—30%. В конце откорма живая масса шаролезских и лимузинских помесных бычков была выше, чем у их сверстников материнских пород, на 13,0 и 7,1% соответственно. Наиболее высокие затраты корма на прирост были у особей красной степной и швицкой пород — 8,0—7,9 ЭКЕ, у шаролезских и лимузинских помесей — 7,3—7,7 ЭКЕ. Помесный молодняк превосходил чистопородных бычков по массе и выходу туш. Шаролезские помеси имели выход туши 60,8—62,4%, лимузинские — 58,7—60,2%. В результате откорма превышение прироста живой массы у помесных животных составляло 11,5—9,1%, а масса туши и жира возросла на 31—32%. У помесей красной степной породы удельный вес мяса и жира в туше после нагула в среднем в обеих группах составил 69,9%, а у помесей швицкой породы — 73,4%, в то время как в конце откорма этот показатель увеличился до 75,0 и 81,3% соответственно. Установлено, что скрещивание шаролезских и лимузинских быков с коровами швицкой породы более эффективно, чем скрещивание этих пород с коровами красной степной породы.
One of the effective solutions in cattle breeding can be crossbreeding of beef bulls with cows of combined and dairy direction of productivity. The research was carried out in an agricultural enterprise of the Karachay-Cherkess Republic. The meat productivity of Charolais and Limousin mixes with red steppe and Shvitz cows was studied. It was found that at birth Charolais litters differed from purebred individuals by 42—70%, and Limousin litters by 29—30%. At the end of fattening the live weight of Charolais and Limousin crossbred steers was 13.0 and 7.1% higher than that of their peers of maternal breeds, respectively. The highest feed costs per gain were in Red Steppe and Shvitz breeds — 8.0—7.9 ECU, in Charolais and Limousin littermates — 7.3—7.7 ECU. The pomace bulls were superior to purebred bulls in terms of carcass weight and carcass yield. Charolais pigs had a carcass yield of 60.8—62.4%, Limousin pigs — 58.7—60.2%. As a result of fattening, the excess of live weight gain in pomace animals was 11.5—9.1%, and carcass weight and fat increased by 31—32%. The specific weight of meat and fat in the carcass of red steppe breed pigs after fattening averaged 69.9% in both groups and 73.4% in Shvitz breed pigs, while at the end of fattening this indicator increased to 75.0 and 81.3%, respectively. It was found that crossing Charolais and Limousin bulls with Shvitz cows is more effective than crossing these breeds with red steppe cows.
Chronic disease medication management at home: a quantitative survey among 180 patients
Authors: Bayen Sabine , Haegeman Yolaine , Messaadi Nassir , Bayen Marc , Ponchant Maurice , Haro Anthony , Quersin François , Calafiore Matthieu 
Published: July 2024

Background
In France, 40% of people aged >16 years (20 million) report having at least one chronic disease requiring long-term treatment. Compliance with treatment at home is estimated to be 50% on average.

Aim
To study the practical management of oral treatments at home by people living with one or more chronic diseases.

Design & setting
A quantitative, descriptive, observational, cross-sectional study. Thirty GPs in France were invited by email to enrol 10 consecutive patients with chronic diseases.

Method
Standardised questionnaires were used to assess the sociodemographic profile of doctors and patients, and the management of oral medication at home.

Results
Twenty GPs collected 180 questionnaires of which 70% responders said they did not find taking their medication a problem; 43% used a pillbox; 79% said they knew 'all' their medications; and 61% reported forgetting to take their medication (versus 30% who reported never forgetting to take their medication).

Conclusion
More than half of patients are non-adherent to taking oral medication at home for their long-term conditions. Personalised reminders could reduce unintentional medication non-adherence.
Exploring the Relationship Between Corporate Social Responsibility and Corporate Sustainability within the Food and Beverage Industry
Authors: Fatunnisa Hani , Hamdani Nizar Alam , Permana Intan 
Published: July 2024

The objective of this paper is to examine the relationship between corporate social responsibility and corporate sustainability. Moreover, the paper examines how dimensions correlate with corporate sustainability. This research uses quantitative research methods. The data analysis technique used is simple linier regression with the help of SPSS 29. Based on the results of the research conducted, there is a relathionship between corporate social responbility and corporate sustainability. The result of this study support the result of previous studies that by using a corporate social responbility approach, companies will not only get economic benefits, but will also get social benefits. Thus the sustainability of the companies can take place well. It is concluded that companies with corporate social responsibility approach, the company not only gains economic benefits but gains social benefits. Business continuity can last well over a long period of time. This research has benefits so that business owners in various industries continue to carry out environment responsibility for business sustainability. In addition, the study also finds a positive relationship between corporate social responsibility and corporate sustainability. The analysis of the paper is based on survey responses from 44 stakeholders (i.e., shareholders, employees, and customers) within the food and beverage industry.
Pengaruh Motivasi Dan Lingkungan Kerja Terhadap Kinerja Karyawan Pada Umkm Zocha Graha Kriya
Authors: Purnomo Hadi , Saputri R A , Gurning K , Azhari Z F , Akbar M I , Mualim A 
Published: July 2024

Tujuan dari penelitian ini untuk mengetahui bagaimana lingkungan kerja dan motivasi karyawan dapat berpengaruh terhadap kinerja mereka di UMKM Zocha Graha Kriya. Sebagaimana diketahui bahwa motivasi sangat penting untuk sebuah perusahaan. Dengan adanya motivasi dan lingkungan kerja yang positif, karyawan dapat melakukan pekerjaan mereka dengan baik dan mencapai hasil terbaik untuk perusahaan. Penelitian ini menggunakan metode analisis kualitatif deskriptif dengan teknis analisis SWOT (Strengths, Weakneeses, Opportunities, Threats), IFAS (Internal Factor Analysis Summary), EFAS (Eksternal Factor Analysis Summary) dan IE (Internal-External). Nilai yang dihasilkan dari matrik IFAS dan EFAS di atas rata-rata dari semua faktor internal dan eksternalnya. Menurut analisis matrik SWOT, Strategi Strengths Opportunities (SO) memiliki skor nilai tertinggi. Posisi UMKM Zocha Graha Kriya ditunjukkan oleh hasil analisis matriks Internal Eksternal (IE) pada kuadran I yang menunjukan kondisinya secara internal memiliki situasi yang sangat menguntungkan. Selain itu, UMKM Zocha Graha Kriya berada dalam posisi yang mendukung kebijakan pertumbuhan yang agresif (growth oriented strategy), seperti yang ditunjukkan dalam posisi kuadran I. Strategi Strengths Opportunities (SO) harus didukung dengan cara memaksimalkan kekuatan yang dimiliki, UMKM ini perlu meningkatkan kemampuan sumber daya manusia (human resource capabilities), pemasaran produk (product marketing) dan inovasi produk (product innovation).
Kata Kunci : Motivasi, Lingkungan Kerja, Kinerja Karyawan
Operating Capacity, Sales Growth, Managerial Agency Costs, Ownership Structure on Financial Distress in Indonesian Companies
Authors: Puspasari Oktaviani Rita , Zahra Salsabila , Purnama* Dendi , Embuningtyas Sandra Sukma 
Published: July 2024

This research aims to examine the influence of operational capacity, sales growth, managerial agency costs, managerial ownership, and institutional ownership on financial distress. The research method used is both descriptive and verificative. The study's population comprises companies in the transportation and logistics sector listed on the Indonesia Stock Exchange from 2017 to 2021. A total of 23 companies over five years, resulting in 115 data observations, were selected using purposive sampling. Hypothesis testing was conducted using panel data regression analysis. The research findings indicate that operational capacity and sales growth have a significant negative impact on financial distress. However, managerial agency costs and managerial ownership have a significant positive impact on financial distress. Meanwhile, institutional ownership also has a significant negative impact on financial distress. This study contributes to the corporate governance literature by predicting factors related to financial distress and providing empirical evidence for the use of the Springate Method in predicting financial distress.
Keywords: Operating Capacity; Sales Growth; Managerial Agency Costs; Ownership Structure; Financial Distress

Abstrak
Penelitian ini bertujuan untuk menguji pengaruh kapasitas operasi, pertumbuhan penjualan, biaya keagenan manajerial, kepemilikan manajerial, dan kepemilikan institusional terhadap financial distress. Metode yang digunakan adalah deskriptif dan verifikatif. Populasi penelitian yaitu perusahaan sektor jasa transportasi dan logistik yang terdaftar di Bursa Efek Indonesia tahun 2017-2021. Jumlah sampel sebanyak 23 perusahaan selama 5 tahun atau 115 data observasi menggunakan teknik purposive sampling. Pengujian hipotesis menggunakan analisis regresi data panel. Temuan penelitian menunjukkan bahwa kapasitas operasi dan pertumbuhan penjualan berpengaruh negatif signifikan terhadap kesulitan keuangan. Namun biaya keagenan manajerial dan kepemilikan manajerial berpengaruh positif signifikan terhadap financial distress. Sementara itu, kepemilikan institusional juga berpengaruh negatif signifikan terhadap financial distress. Penelitian ini memberikan literatur mengenai peran mekanisme tata kelola perusahaan dalam memprediksi kesulitan keuangan dan memberikan bukti empiris penggunaan Metode Springate dalam memprediksi kesulitan keuangan.
Kata Kunci: Kapasitas Operasional; Pertumbuhan Penjualan; Biaya Agensi Manajerial; Kepemilikan Manajerial; Kesulitan Keuangan
A Microscope Medley for High School Students
Authors: Parthasarathy Raghuveer 
Published: July 2024

ABSTRACT
Microscopy is crucial to much of biophysics. The variety of approaches to imaging exemplified by contemporary microscopes is remarkable, yet this breadth is generally unknown to students, limiting perceptions of biology, physics, and related fields and of potential career paths. We therefore created and implemented an outreach activity as part of a day camp that especially targeted low-income high school students. The students engaged with 3 very different microscopes: a simple transmitted light microscope; a light sheet fluorescence microscope; and a newly invented multicamera array microscope. With these instruments, we examined subjects such as transgenic zebrafish larvae with fluorescent immune cells, contrasting the various instruments’ capabilities, including resolution and field of view. Pre- and postactivity questions showed that the activity succeeded in expanding students’ understanding and appreciation of the varied aims and abilities of modern microscopes and moreover led to discussions of model organisms, biophysics, and science funding. Additional activities briefly illustrated the nature of digital images and mathematic manipulation. I describe here the activities and goals, as well as ways they can be generalized and implemented at other institutions with access to different sorts of imaging tools.
SOLUSI MENGATASI DUALITAS PENGATURAN SANKSI ADMINISTRASI ATAU SANKSI PIDANA DALAM UNDANG-UNDANG KETENTUAN UMUM PERPAJAKAN
Authors: Suharsono Agus , Prasetyoningsih Nanik 
Published: July 2024

Penelitian ini menganalisis dualitas ketentuan pengenaan sanksi administrasi atau sanksi pidana bagi WP yang tidak mendaftarkan diri untuk diberikan NPWP atau tidak melaporkan usahanya untuk dikukuhkan sebagai PKP sehingga menimbulkan kerugian negara karena dapat menimbulkan ketidakpastian hukum dan ketidakadilan. Penelitian ini adalah penelitian doktrinal yang menganalisis sumber hukum primer dan sekunder dengan pendekatan perundang-undangan, pendekatan konseptual, dan pendekatan analitis. Hasil penelitian diketahui bahwa Undang-Undang KUP sudah mengatur sanksi administrasi bagi WP yang tidak mendaftarkan diri untuk diberikan NPWP atau tidak melaporkan usahanya untuk dikukuhkan sebagai PKP sehingga menimbulkan kerugian negara yaitu dengan pemberian NPWP dan pengukuhan PKP secara jabatan serta penerbitan SKPKB beserta sanksi administrasinya. Berdasarkan asas-asas pembentukan peraturan perundang-undangan dan asas hukum hulprecht, una via, ultimum remedium, serta nullum delictum, nulla poena, sine praevia lege poenali karena sudah ada ketentuan pengenaan sanksi administrasi, maka untuk kepastian hukum dan keadilan ketentuan Pasal 39 ayat (1) huruf a Undang-Undang KUP sebaiknya dihapus agar tidak ada dualitas pengenaan sanksi atas pelanggaran yang sama.
The Effect of Ease of Use, Usefulness, Trust, and Security on Decisions Using M-Banking Bank Syariah Indonesia
Authors: Hasyim Fuad , Sari Intan , Rahayu Nanik 
Published: July 2024

This study aims to analyze the effect ofÂ ease of use, usefulness,Â trust, and security to decision using m-banking BankÂ Syariah Indonesia. This study used a questionnaire to collect data and reach 100 respondents. The respondent is a customer who usesÂ m-banking Bank Syariah Indonesia. Sample determination uses simple random sampling method, and the analysis method using multiple linear regression analysis. The results of this study are usefulness,Â trust,Â andÂ securityÂ variables influence the decision to use m-banking Bank Syariah Indonesia.Â In contrast, the ease of use does not affect the decision to use m-banking Bank Syariah Indonesia.Â These findings indicate that the m-banking system needs to be upgraded to minimize cases of transaction errors, bugs and slow access.
Pengaruh Motivasi Kerja, Kompetensi, dan Lingkungan Kerja Terhadap Kinerja Karyawan PT Pegadaian Area Semarang
Authors: Puspitasari Amalia , Kodir Mochammad Abdul , Muslikh Moh. 
Published: July 2024

ABSTRACTThis research aims to identify the effect of Work Motivation, Competence, and Work Environment simultaneously or partially towards Employees Performance at PT Pegadaian Semarang Area. The population in this research are all employee at PT Pegadaian Semarang Area. The sampling technique uses Slovin formula, as amount to 72 respondents. The data uses in this research are primary data obtained through distributing questionnaires. The data analysis model used the Multiple Linear Regression Analysis Model. Data analysis technique uses the Test Statistic T, Test Statistic F, and The Coefficient of Determination (R2). The result of the analysis and discussion shows that the variable of work motivation, competence, and work environment simultaneously had a significant effect on employee performance at PT Pegadaian Semarang Area. Partially, work motivation and competence variable each has a significant effect whereas work environment variable partially has no significant effect on employee performance at PT Pegadaian Semarang Area.Keywords: Work Motivation, Competence, Work Environment, Employee Performance ABSTRAKPenelitian ini bertujuan untuk mengetahui signifikansi Pengaruh Motivasi Kerja, Kompetensi, dan Lingkungan Kerja Terhadap Kinerja Karyawan PT Pegadaian Area Semarang baik secara simultan maupun parsial. Populasi dalam penelitian ini adalah seluruh karyawan PT Pegadaian Area Semarang. Teknik pengambilan sampel menggunakan rumus Slovin, sebanyak 72 responden. Data yang digunakan dalam penelitian ini adalah data primer yang diperoleh melalui penyebaran kuesioner. Model analisis data menggunakan Model Analisis Regresi Linier Berganda. Sedangkan Teknik analisi data menggunakan Uji Statistik F, Uji Statistik T, dan Koefisien Determinasi (R2). Hasil analisis dan pembahasan menunjukkan bahwa variable motivasi kerja, kompetensi, dan lingkungan kerja secara simultan berpengaruh signifikan terhadap kinerja karyawan PT Pegadaian Area Semarang. Secara parsial, variable motivasi kerja dan kompetensi berpengaruh signifikan terhadap kinerja karyawan, sedangkan variable lingkungan kerja secara parsial tidak berpengaruh signifikan terhadap kinerja karyawan PT Pegadaian Area Semarang.Kata Kunci: Motivasi Kerja, Kompetensi, Lingkungan Kerja, Kinerja Karyawan.