bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated basophil count is associated with increased odds of endometriosis
Authors: Feng Qian , Shigesi Nina , Guan Jun , Rahmioglu Nilufer , Bafadhel Mona , Paddon Kevin , Hubbard Carol , Zondervan Krina T , Becker Christian M , Hellner Karin 
Published: July 2024

Graphical abstract

Abstract
Immunological dysregulation plays a fundamental role in the inflammatory aspects of endometriosis. Circulating blood leukocytes, one of the most abundant immune cell populations in the human body, have been shown diagnostic significance in some diseases. Nevertheless, the association between peripheral blood leukocyte counts and endometriosis remains unexplored to date.
We analyzed two targeted study cohorts: a tertiary center cohort (Endometriosis at Oxford University (ENDOX) Study: 325 cases/177 controls) and a large-scale population study (UK Biobank (UKBB): 1537 cases/6331 controls). In both datasets, peripheral venous blood sample results were retrieved, and counts of leukocyte subpopulations, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils, were analyzed. Logistic regression models were used to investigate the association of leukocyte subtype alterations with endometriosis status, adjusting for confounding factors. We demonstrate that a higher blood basophil level is associated with increased odds of endometriosis. This association was first discovered in the ENDOX cohort (basophils >0.04 × 109/L: OR 1.65 (95% CI: 1.06–2.57), Ptrend = 0.025) and replicated in the UKBB dataset (basophils >0.04 × 109/L: OR 1.26 (95% CI: 1.09–1.45), Ptrend = 0.001). Notably, women with basophil counts in the upper tercile had significantly increased odds of having stage III/IV endometriosis (ENDOX study: OR = 2.30, 95% CI (1.25–4.22), Ptrend = 0.007; UKBB study (OR = 1.40, 95% CI (1.07–1.85), Ptrend = 0.015). None of the other leukocyte subtypes showed an association. Our findings suggest an association between inflammatory responses and the pathogenesis of endometriosis; future studies are warranted to investigate whether the association is causal.

Lay summary
Endometriosis is a long-term disease affecting approximately 10% of women during their fertile age. It happens when the tissue similar to the lining of the womb grows in other parts of the body, commonly causing pelvic pain and subfertility. Most diagnostic tests for endometriosis are neither accurate nor reliable, leading to a long wait before a correct diagnosis. Looking for changes in blood cell counts could guide doctors for further testing to confirm diagnosis. Our study shows that a higher number of basophils, a specialized type of white cells, commonly measured in a simple blood test, are positively linked with a higher likelihood of endometriosis. The link becomes stronger in severe endometriosis cases. Although we are showing a robust link, whether this can be used to find endometriosis sooner needs to be tested in future studies.
Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity
Authors: Jensen Erik A. , DeMauro Sara B. , Rysavy Matthew A. , Patel Ravi M. , Laughon Matthew M. , Eichenwald Eric C. , Do Barbara T. , Das Abhik , Wright Clyde J. ,   Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Published: July 2024

OBJECTIVE
Emerging data indicate that acetaminophen may adversely affect lung health. We examined whether acetaminophen compared with cyclooxygenase (COX) inhibitor alone for patent ductus arteriosus (PDA) is associated with mortality or respiratory morbidity in extremely preterm infants.

METHODS
This is a retrospective cohort study using data from the National Institute of Child Health and Human Development Neonatal Research Network. Infants were born at 22 to 28 weeks’ gestation or weighing 401 to 1000 g between 2016 and 2020 and received acetaminophen, ibuprofen, and/or indomethacin for PDA closure. The primary outcome was death or grade 2 to 3 bronchopulmonary dysplasia (BPD) at 36 weeks’ postmenstrual age. Secondary outcomes included predischarge mortality and respiratory morbidities. Risk ratios were adjusted for baseline and early postnatal factors. Additional exploratory analyses were adjusted for later postnatal covariates.

RESULTS
Of 1921 infants, 627 (32.6%) received acetaminophen and 1294 (67.3%) received COX inhibitor only. Multidrug therapy (42.9% vs 4.7%) and surgical or catheter PDA closure (26.5% vs 19.9%) were more common among acetaminophen-exposed infants. Death or grade 2 to 3 BPD at 36 weeks’ postmenstrual age was similar between infants treated with acetaminophen versus COX inhibitor only (57.1% vs 58.3%; adjusted relative risk [aRR] 0.96, 95% confidence interval [CI] 0.87–1.06). Acetaminophen was associated with increased risk of predischarge mortality (13.3% vs 10.0%) when adjusting for perinatal and early postnatal factors (aRR 1.42, 95% CI 1.02–1.93), but not in exploratory analyses that included later postnatal factors (aRR 1.28, 95% CI 0.91–1.82).

CONCLUSIONS
Treatment with acetaminophen versus COX inhibitor alone for PDA was not associated with the composite outcome of death or BPD in extremely preterm infants. Our results support further evaluation of whether acetaminophen for PDA increases mortality.
ОБГРУНТУВАННЯ ПАРАМЕТРІВ ПАСТЕРИЗАЦІЇ МОЛОКА У ТЕХНОЛОГІЇ СИРУ М’ЯКОГО КАМАМБЕР
Authors: Чагаровський О. П. , Ткаченко Н. А. , Дідух Е . Г. , Анічін В. В. 
Published: July 2024

Анотація. У статті розглянуто вплив параметрів пастеризації молока корів Гольштинської породи на Молочній Фермі Прикарпаття ТОВ «МУККО» у технології м’якого сиру Камамбер на вихід сиру, масову частку білків і жиру у сирі Камамбер та хімічний склад сироватки, а також визначено ефективність теплового оброблення молока за різних режимів пастеризації. Досліджено контрольний (температура 80 ºС, витримування 20 сек.) та три експериментальні режими пастеризації молока – перший експериментальний режим: температура 80 ºС, витримування 5 хв.;другий експериментальний режим: температура 85 ºС, витримування 20 сек.;третій експериментальний режим: температура 85 ºС, витримування 5 хв.
Визначено, що підвищення температури пастеризації молока з 80ºС до 85ºС та подовження витримування від 20 сек. до 5 хв. сприяє підвищенню виходу сиру м’якого Камамбер на 6,3%. Визначено вплив параметрів пастеризації молока на масову частку білка та жиру у сирі м’якому Камамбер: максимальний вміст білків має сир Камамбер, вироблений із молока, пастеризованого за температури 85 ºС з витримуванням 5 хв., водночас такий сир містить мінімальну кількість жиру (57,5% у сухій речовині сиру), що потребує корегування процесу нормалізації молока у технології м’якого сиру Камамбер при застосуванні нового режиму пастеризації.
Встановлено, що підвищення температури пастеризації молока та тривалості витримування його при цій температурі сприяє зменшенню вмісту сухих речовин у сироватці, зокрема, за рахунок зменшення масової частки білків, які переходять до сироватки у процесі синерезису.
Визначено, що пастеризація молока за температури 85ºС з витримуванням 20 сек. та 5 хв. забезпечує високу ефективність теплового оброблення (99,99 %) та інактивацію усіх ферментів, що забезпечить стабільну та прогнозовану якість готового продукту, оскільки у визріванні сиру м’якого Камамбер будуть приймати участь лише ферменти заквашувальних культур.
На основі проведених досліджень рекомендовано у технології сиру м’якого Камамбер використовувати пастеризацію молока за температури 85 ºС з витримуванням 5 хв.
Renovascular Disease and Mitochondrial Dysfunction in Human Mesenchymal Stem Cells
Authors: Eirin Alfonso , Siddiqi Sarosh , Hughes Autumn G. , Jiang Yamei , Zhu Xiang-Yang , Kazeminia Sara , Lu Bo , Xing Li , Lu Brandon , Tang Hui , Xue Ailing , Lerman Amir , Textor Stephen C. , Lerman Lilach O. 
Published: July 2024

Key Points

Renovascular disease impairs the capacity of human adipose tissue–derived mesenchymal stem/stromal cells to repair ischemic murine kidneys.miR-378h modulated the capacity of renovascular disease adipose tissue–derived mesenchymal stem/stromal cells to repair ischemic kidneys in vivo.

Background
Renovascular disease leads to renal ischemia, hypertension, and eventual kidney failure. Autologous transplantation of adipose tissue–derived mesenchymal stem/stromal cells (MSCs) improves perfusion and oxygenation in stenotic human kidneys, but associated atherosclerosis and hypertension might blunt their effectiveness. We hypothesized that renovascular disease alters the human MSC transcriptome and impairs their reparative potency.

Methods
MSCs were harvested from subcutaneous abdominal fat of patients with renovascular disease and healthy volunteers (n=3 each), characterized and subsequently injected (5×105/200 μl) into mice 2 weeks after renal artery stenosis or sham surgery (n=6/group). Two weeks later, mice underwent imaging and tissue studies. MSCs from healthy volunteers and in those with renovascular disease were also characterized by mRNA/microRNA (miRNA) sequencing. Based on these, MSC proliferation and mitochondrial damage were assessed in vitro before and after miRNA modulation and in vivo in additional renal artery stenosis mice administered with MSCs from renovascular disease pretreated with miR-378h mimic (n=5) or inhibitor (n=4).

Results
MSCs engrafted in stenotic mouse kidneys. Healthy volunteer MSCs (but not renovascular disease MSCs) decreased BP, improved serum creatinine levels and stenotic-kidney cortical perfusion and oxygenation, and attenuated peritubular capillary loss, tubular injury, and fibrosis. Genes upregulated in renovascular disease MSCs versus healthy volunteer MSCs were mostly implicated in transcription and cell proliferation, whereas those downregulated encoded mainly mitochondrial proteins. Upregulated miRNAs, including miR-378h, primarily target nuclear-encoded mitochondrial genes, whereas downregulated miRNAs mainly target genes implicated in transcription and cell proliferation. MSC proliferation was similar, but their mitochondrial structure and reparative function both in vivo and in vitro improved after miR-378h inhibition.

Conclusions
Renovascular disease impaired the reparative capacity of human MSCs, possibly by dysregulating miR-378h that targets mitochondrial genes.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2024_08_21_ASN0000000000000440.mp3
Employee Engagement, Organizational Commitment and Employee Performance: The Mediating Role of Organizational Citizenship Behavior
Authors: Nizar Mutia Attalia , Mintarti Rahayu , Christin Susilowati 
Published: July 2024

This study aims to analyze the role of organizational citizenship behavior as a mediation effect of employee engagement and organizational commitment on employee performance. This research includes quantitative research using questionnaires to collect data. The population in this study were RSIA Puri Bunda Malang employees. The sampling technique used proportional random sampling with a total sample of 119 respondents. The data analysis technique involved SEM-PLS (Structural Equation Modeling-Partial Least Square). The results indicated that employee engagement and organizational commitment had no effect on employee performance, while organizational citizenship behavior significantly can affect employee performance. The results also showed that organizational citizenship behavior can mediate both the effect of employee engagement and organizational commitment to employee performance. It indicates that the attitude of employee engagement and organizational commitment of employees does not affect employee performance. The presence of organizational citizenship behavior will strengthen the effect of employee engagement and organizational commitment on employee performance. Keywords: Employee engagement, Employee performance, Organizational commitment, Organizational citizenship behavior
Cultuurstelsel kopi Mandailing: antara aroma, derita kerja paksa, dan jalan raya
Authors: Sugandi Rafid , Hakim Lukmanul , Erasiah Erasiah 
Published: July 2024

This research reveals the history of Cultuurstelsel in Mandailing. The problems are the history of Cultuurstelsel, the practice of forced labor, and the construction of roads. The method used is the historical method. The stages of the historical method are source collection, source criticism, interpretation, and writing. The results showed that the coffee Cultuurstelsel (forced planting system) in Mandailing began in 1841 AD. The Mandailing coffee forced planting system is successful and dominates the world market. Mandailing coffee is the best quality coffee in the world. It is exported to America and Europe. The forced planting of Mandailing coffee and the delivery of coffee from Mandailing to Natal caused many residents to suffer, especially the laborers (coffee transporters). To speed up and multiply the slow coffee transportation, the Natal roadway was built, which was inaugurated by Van Swieten in March 1851 AD. Penelitian ini bertujuan untuk mengungkapkan Cultuurstelsel di Mandailing. Permasalahannya ialah sejarah Cultuurstelsel, praktik kerja paksa, dan pembangunan jalan raya. Metode yang digunakan adalah metode sejarah. Tahapan metode sejarah yaitu pengumpulan sumber, kritik sumber, penafsiran dan penulisan. Hasil penelitian menunjukkan Cultuurstelsel (sistem tanam paksa) kopi di Mandailing telah dimulai pada 1841 M. Sistem tanam paksa kopi Mandailing berhasil dan merajai komoditi ekspor pasar dunia terutama, Amerika dan Eropa. Kopi Mandailing “Mandheling Coffee” dinobatkan sebagai kopi dengan kualitas terbaik di dunia. Dalam prosesnya kopi dari Mandailing diangkut ke pelabuhan Natal, Padang, dan ke Eropa. Eksploitasi manusia secara paksa selama tanam paksa kopi Mandailing dan pengiriman kopi dari Mandailing ke Natal menyebabkan banyak penduduk yang menderita, terutama para buruh (pengangkut kopi). Oleh karena itu, untuk mempercepat dan memperbanyak pengangkutan kopi sebelumnya berjalan lambat, maka dibangunlah jalan raya Natal (penghubung dari Mandailing ke Natal) yang diresmikan oleh Van Swieten pada bulan Maret 1851 M.
The Secret Garden of Pakisjajar: Pengembangan Desa Wisata Berbasis Kearifan Lokal
Authors: Amiq Fahrial , Angga Prayogi Dwina 
Published: July 2024

Berbagai potensi yang dimiliki oleh Desa Pakisjajar tentunya dapat menjadi satu lokasi yang memungkinkan untuk dikembangkan sebagai objek wisata. Salah satu potensi yang dapat dikembangkan di Desa Pakisjajar adalah adanya enam sumber mata air yang cukup melimpah. Kegiatan pengandian kepada masyarakat dilakukan dengan pendekatan dengan memberikan kesempatan seluas-luasnya dan mengajak masyarakat Desa Pakisjajar untuk berperan serta secara aktif dalam proses pembangunan, pengembangan dan mewujudkan desa wisata yang berbasis alam. Terdapat tiga tahapan yang dilakukan pada kegiatan pengabdian kepada masyarakat ini, yaitu (1) penggalian informasi dan analisis kebutuhan; (2) penyusunan desain perencanaan; dan (3) perbaikan aksesibilitas. Hasil kegiatan pengabdian kepada masyarakat ini dikonstruksi dalam bentuk analisis kebutuhan sebagai dasar membuat rencana, rancangan atau desain tiga dimensi yang dapat dijadikan rencana induk pengembangan lokasi wisata di desa Pakisjajar dan menghasilkan prasarana berupa jalan (aksesibilitas) sebagai salah satu prasyarat dasar dalam pengembangan desa wisata. Adanya pengembangan kepariwisataan berbasis masyarakat pada kegiatan ini telah menjadikan sumber daya lokal dengan segala potensi yang dimiliki untuk dikelola secara swadaya guna peningkatan kesejahteraan masyarakat di Desa Pakisjajar. Kata kunci— Desa wisata, Pengembangan desa, Kearifan lokal Abstract The various potentials of Pakisjajar village can certainly be a location that allows it to be developed as a tourist attraction. The potentials that can be developed in Pakisjajar village is the existence of six springs which are quite abundant. Community service activities are carried out with an approach by providing the widest opportunity and inviting the Pakisjajar village community to participate actively in the process of development, development and realizing a nature-based tourism village. There are three stages carried out in this community service activity, namely (1) extracting information and analyzing needs; (2) preparation of planning designs; and (3) accessibility improvements. The results of this community service activity are constructed in the form of a needs analysis as a basis for making plans, designs or three-dimensional designs that can be used as a master plan for the development of tourist sites in Pakisjajar village and produce infrastructure in the form of roads (accessibility) as one of the basic prerequisites in developing a tourist village. The existence of community-based tourism development in this activity has made local resources with all their potential to be managed independently in order to improve the welfare of the community in Pakisjajar Village. Keywords— Village-based tourism, Village Development, Local Wisdom
Analysis on the condition and function of the “Ba” construction into the Bare-verb
Authors: Shi Shaojie 
Published: July 2024

The construction of "Ba" has always been one of the focus of modern Chinese research. This is not only because it is complicated and diverse in structure, but also is closely related to the semantic relationship expressed. This article analysis Bare-verb which can enter “Ba” construction, explore the scenario of the application of the sentence, and think about the teaching practice of the structure for the application scenario. This study divided Bare-verb into single syllables, two-syllables and multi-syllables Bare-verb according to syllables. By analyzing, the single syllables of Bare-verb must have the condition of rhetoric; the two-syllables of bare-verbs must have removal, completion and continuous righteousness. The multi-syllables of Bare-verb appear in the form of "-hua". The conclusion is that this type of Bare-verb will appear in prayer sentences, negative sentences, doubts, and compound sentences, and the sentence pattern has the asymmetric and enhanced language function.
Prevalence of preeclampsia and its associated risk factors in Rajshahi region, Bangladesh
Authors: Akhter Sultana Nasima , Khatun Rokeya , Shamima Mosammat Nargis , Sultana Nahid , Khatun Amina , Akhtar Rawshan , Jahan Nargis , Begum Monowara , Haque M. Jawadul , Hassan Parvez 
Published: July 2024

Background: Although preeclampsia claims lives of 70,000 mothers and 500,000 newborns each year, in Bangladesh the comprehensive data-sets are not well-documented. We studied the prevalence of preeclampsia, its trend and the associated risk factors in Rajshahi, Bangladesh.
Methods: Using a cross-sectional longitudinal design, 90 women hospitalized with preeclampsia in 7 hospitals of Rajshahi, Bangladesh were considered in the study, of which Rajshahi medical college hospital (RMCH) is a tertiary referral hospital. The data were collected by interviewing the patients, physical examinations and analyzing patients’ pathological profile. For statistical analyses, SPSS software was employed.
Results: During the five years (2013-2017), RMCH admitted pregnant mothers for delivery or with obstructed complications had increased from 11,523 to 17,201, leading to an increase in preeclamptic patients from 407 to 435. Its prevalence rate (3.21%) was found to be decreased linearly with time. The preeclamptic patients were of 16-40 years, averaging 25.90±0.65 years. The youngest (£20 years) preeclamptic mothers (24%) were at high risk of preeclampsia. The obese (40%) and overweight (29%) preeclamptic mothers experienced severe oedema, headache, vomiting, lower abdominal pain and hyperacidity. About three-fourths of the concerned patients were of lower socio-economic class, of which the majority was below education level 10. The majority were from joint families (58%) who took less than 2.2 L of drinking water per day.
Conclusions: The average prevalence preeclampsia rate was 3.21% that was found to decrease linearly with time. The youngest but obese (BMI of ³30 kg/m2) mothers were vulnerable for preeclampsia. Other risk factors include lower socio-economic class, less education, white complexion, joint family type and taking less amount of fluid.
Navigating the Complex Nature of Obesity Between Being A Chronic Disease or Personal Responsibility: Have You Betrayed Your Body or Have Your Body Betrayed You?
Authors: Atta Sama 
Published: July 2024

Obesity is a complex multifactorial condition that accumulated excess body fat leads to negative effects on health. Obesity continues to accelerate resulting in a pandemic that shows no significant signs of slowing down any time soon. Raised body mass index (BMI) is a risk factor for noncommunicable diseases such as diabetes, cardiovascular diseases, and musculoskeletal disorders, resulting in dramatic decrease of life quality and expectancy. The main cause of obesity is long-term energy imbalance between consumed calories and expended calories. Here, we explore the biological mechanisms of obesity with the aim of providing actionable treatment strategies to achieve a healthy body weight from nature to nurture. This review summarizes the global trends in obesity with a special focus on the pathogenesis of obesity from genetic factors to epigenetic factors, from social environmental factors to microenvironment factors.
Skazani na współpracę? Różne wymiary polityki Unii Europejskiej wobec państw azjatyckich
Authors: Iczetkin Aleksandra , Gajda Olga , Rusiecka Kamila , Kisiel Adrianna , Kukieła Julia , Suszwalak Oliwia , Filipińska Aleksandra , Serwatka Andżelika , Czapla Karolina , Pęczak Maciej , Bednarska Wiktoria , Gralewska Daria 
Published: July 2024

Polityka Unii Europejskiej wobec Azji stanowi interesujący obszar analizy i refleksji na tle zmieniającej się rzeczywistości międzynarodowej. UE, od momentu swojego powstania, zyskała pozycję znaczącego gracza na arenie międzynarodowej. Azja, z kolei, od połowy lat 90. XX wieku, stała się jednym z kluczowych obszarów dla polityki zagranicznej UE. To partnerstwo przekształcało się i rozwijało w odpowiedzi na zmieniające się okoliczności i wyzwania, stając się nieodłączną częścią globalnej strategii Unii. Początkowo skupiając się na kwestiach gospodarczych, obecnie współpraca unijno-azjatycka obejmuje szerokie spektrum tematyczne od handlu, polityki i bezpieczeństwa, przez dążenie do zrównoważonego rozwoju, ochronę środowiska i klimatu, po wzmacnianie praw człowieka i społeczeństwa obywatelskiego. Polityka UE wobec Azji wywodzi się zarówno z praktycznego podejścia, skupiającego się na rozwijaniu wymiany handlowe, jak i z dążenia do promowania wartości, takich jak demokracja, prawa człowieka i zrównoważony rozwój. UE jako wspólnota, która zbudowana jest na fundamentach pokoju, demokracji i praworządności, stawia na promocję tych wartości na arenie międzynarodowej, co przekłada się na jej aktywną rolę w Azji. Celem niniejszej książki jest przybliżenie polskiemu czytelnikowi wybranych aspektów współpracy UE z Azją, w trzech wzajemnie powiązanych obszarach: polityce rozwojowej, współpracy w zakresie ochrony środowiska i zmian klimatycznych oraz działań UE na rzecz rozwoju społeczeństwa obywatelskiego w Azji. Tematy te łączy to, że są istotnymi elementami polityki unijnej wobec Azji, a przy tym były w niewielki tylko stopniu analizowane w polskiej literaturze przedmiotu. Stąd też książka pozwala zrozumieć kompleksowy obraz specyfiki i dynamiki relacji między UE z kontynentem azjatyckim.

Publikacja powstała w ramach projektu Jean Monnet Module „Europe as an Actor in Asia”, finansowanego przez Komisję Europejską
Projekt współfinansowany w ramach programu Unii Europejskiej Erasmus +