bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles
Authors: Tothill Richard , Flynn Aidan , Pattison Andrew , Balachander Shiva , Boehm Emma , Bowen Blake , Dwight Trisha , Rossello Fernando , Hofmann Oliver , Martelotto Luciano , Zethoven Magnus , Kirschner Lawrence , Else Tobias , Fishbein Lauren , Gill Anthony , Tischler Arthur , Giordano Thomas , Noble Jane , Prodanov Tamara , Reddel Roger , Trainer Alison , Ghayee Hans , Bourdeau Isabelle , Elston Marianne , Ishak Nur Diana Binte , Yie Joanne Ngeow Yuen , Hicks Rodney , Crona Joakim , Åkerström Tobias , Stålberg Peter , Dahia Patricia , Grimmond Sean , Clifton-Bligh Roderick , Pacak Karel 
Published: June 2024

Abstract

Hereditary SDHB-mutant pheochromocytomas (PC) and paragangliomas (PG) are rare tumours with a high propensity to metastasize although their clinical behaviour is unpredictable. To characterize the genomic landscape of these tumours and identify metastasis biomarkers, we performed multi-omic analysis on 94 tumours from 79 patients using seven molecular methods. Sympathetic (chromaffin cell) and parasympathetic (non-chromaffin cell) PCPG had distinct molecular profiles reflecting their cell-of-origin and biochemical profile. TERT and ATRX-alterations were associated with metastatic PCPG and these tumours had an increased mutation load, and distinct transcriptional and telomeric features. Most PCPG had quiet genomes with some rare co-operative driver events observed, including EPAS1/HIF-2α mutations. Two mechanisms of acquired resistance to DNA alkylating chemotherapies were also detected - MGMT overexpression and mismatch repair-deficiency causing hypermutation. Our comprehensive multi-omic analysis of SDHB-mutant PCPG therefore identified features of metastatic disease and treatment response, expanding our understanding of these rare neuroendocrine tumours.
Influential Node Detection in Social Networks for Real-World Applications
Authors: Dutta Sangita , Kule Malay , Chakraborty Susanta 
Published: June 2024

Abstract

Influential node detection is a crucial task in real-world networks, such as social networks, biological networks, or information networks. It helps us to understand network dynamics as well as identify important participants. A commonly used method for detecting important nodes involves the utilisation of community detection, which seeks to divide the network into clusters of nodes that reflect high levels of connectivity. The Overlapping Community Detection approach named as Internal-External overlapping Community Detection method has been proposed to find different communities. We have introduced a new factor namely Influence Detection Factor that is used to determine influential node of a network. State transition of every node occurred in a time-varying network. State transition based on the influential node can be useful for tracking different frames of every influential node with time. Dynamic Social network analysis in disease spreading is an emerging field of research. Disease Network can be considered a real-world application in various contexts. We have considered COVID-19 India data as a case study. Each node and edge is depicted as a province/district and the number of COVID-19 cases, in the network respectively. Edge Weight is calculated using our proposed metric. We have used different centrality measures, such as degree centrality, closeness centrality, betweenness centrality, etc., to compare our metrics over real-world datasets. The observations obtained through our proposed method demonstrate a significant correlation with the real-time occurrences. Experimental results of our proposed methodology demonstrate better results in comparison to other existing approaches.
Transforming Decision-Making: A Three-Phase Deployment of an Intuitionistic Fuzzy Environment
Authors: Tarray Tanveer Ahmad , Khaki Zahid Gulzar , Ganie Zahoor Ahmad , Sultan Adil 
Published: June 2024

Abstract

This study proposes a revolutionary approach to decision-making based on the tri-phase execution of an innovative fuzzy logic model. Our work uses a three-stage stratified random sample approach supplemented by a randomized response technique to tackle the critical challenge of minimizing variance while accounting for costs. Using the alpha-cut method, our proposed model generates an efficient allocation strategy that efficiently balances cost constraints and variance reduction goals. We present numerical examples to demonstrate our model's usefulness in real-world scenarios. Our contribution is to provide decision-makers with a comprehensive framework for enhancing data collection methods, especially when respondent privacy is crucial. Our technique, which blends fuzzy logic and randomized response approaches, presents a pioneering solution to the inherent challenges of acquiring sensitive information, while maintaining data integrity and cost-effectiveness.
A novel organic-inorganic nanohybrid, DOPO-AS@M (OH)(OCH3) (M = Co, Ni), enhances the flame retardancy and mechanical properties of epoxy resin
Authors: Duan Qiancheng , Dong Xiang , Sun Zhiyu , Dai Guowei , Li De-long , Xie Le , Liu Song 
Published: June 2024

Abstract

In this work, we synthesized a novel organic-inorganic hybrid, DOPO-AS@M(OH)(OCH3) (DOPO-AS@M (M = Co,Ni)), and utilized it to prepare the epoxy resin (EP) composite with enhanced flame retardancy and mechanical properties. Specifically, the DOPO-AS was synthesized using 3-aminopropyltriethoxysilane (APTES), salicylaldehyde (Salal), and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO). Subsequently, the DOPO-AS was utilized as a surface modification of the novel 2D nanosheet M(OH)(OCH3) and the obtained organic-inorganic hybrid was used to prepare the EP composites. The results showed that the addition of only 5 wt% DOPO-AS@M enabled EP to achieve the UL-94 of V-1 rating, with the limiting oxygen index (LOI) increasing from 28.7–31.0%. The peak heat release rate (pHRR) of EP/DOPO-AS@M 5% was 1007.5 kW/m2, with the reduction of 48% compared to pure EP. In addition, the elongation at break of EP/DOPO-AS@M 5% increased from 3.9–4.2%. The DOPO-AS@M nanohybrid proposed in this study providing the new solution for simultaneously enhanced the flame retardancy and mechanical properties of EP, thus broadening the application of EP in the market.
Simulation of light environments inside lunar holes and their associated subsurface caverns
Authors: Ikeya Kodai , Haruyama Junichi , Miyake Wataru , Tanaka Makoto , Toyokawa Kosei , Nozawa Hitoshi 
Published: June 2024

Abstract

Vertical holes of several tens of meters in diameter and depth have been discovered on the Moon, potentially serving as skylights into subsurface volcanic caverns resembling lava tubes. Because of their scientific importance and potential for use as future lunar bases, these lunar holes and caverns are expected to be targets of intensive exploration in the near future. Using numerical simulations, this study investigates the light environment within a directly and/or indirectly sunlit subsurface cavern accessed through a skylight hole. We specifically analyze the Mare Tranquillitatis Hole (MTH), one of the largest lunar vertical holes, situated near the Moon's nearside meridian. The floor and walls of the hole, and the walls and ceiling of its associated subsurface cavern are lit by reflected sunlight from other parts of the hole and cavern, such as the floors, depending on the solar elevation angle. Furthermore, this paper presents estimation results for camera imaging for a case in which solar elevation angle is 45 degrees in the morning, which is appropriate timing for exploration. Assuming reflectance of 0.1 for the lunar hole and cavern surfaces, we estimate the incident energy onto each pixel of a camera as it descends to the hole's floor. We specifically simulate conditions for a camera with a 12-bit dynamic range, similar to the wide-angle optical navigation camera (ONC-W) onboard the Hayabusa 2 spacecraft. The results suggest that a camera with a fixed gain would struggle to capture both directly and indirectly sunlit areas simultaneously, without saturating bright areas and ensuring minimum incident energy resolution (say, a 10 digital number) for darker areas. To overcome this challenge, adjusting the camera gain based on the hole's and cavern's illumination conditions is necessary.
A Library of Microsatellite Markers for Efficiently Characterizing the Aquatic Macrophyte Myriophyllum heterophyllum
Authors: Bernacki Lucas E 
Published: June 2024

Abstract

Myriophyllum heterophyllum is an aquatic macrophyte that is invasive to the northeastern United States and several western European countries. Spreading by vegetative clonal propagation, especially fragmentation, extensive resources are devoted to limit its growth and spread; however, genetic assessments are not typically included in management strategies. Reduction in genetic (clonal) diversity should accompany biomass reduction, yet without genetic assessment the efficacy of plant removal remains unclear. This paper is the first to describe a microsatellite marker library and its use in characterization of the genetic diversity of Myriophyllum heterophyllum.
Eighty-seven tissue samples were collected across the invasive distribution of Myriophyllum heterophyllum in Maine, USA. DNA was extracted and PCR amplification was employed to screen 13 of the microsatellites published in Wu et al. 2013. Sequencing of the amplified loci was performed to characterize repeat motifs and confirm primer binding sites. Fragment sizing of PCR amplicons was employed to determine microsatellite lengths across the 87 samples.
Eight of the 13 tested markers amplified with seven of those eight found to be variable. Polyploidy was evident from allelic diversity within individuals, although precise ploidy could not be determined. Expected heterozygosity ranged from 0.12 to 0.89 across variable markers.
This seven-marker library was effective in characterizing the genetic diversity of both newly discovered (<5 years) and older (>50 years) infestations and is expected to be suitable for assessment of genetic diversity in populations within the native range of M. heterophyllum. The marker library also shows promise for use in several other Myriophyllum species.
A preoperative noninvasive index prediction model for TURP surgical outcomes in patients with benign prostatic hyperplasia
Authors: yang jiyao , zhan hui , yang xiaorong , liang yuan , li ji , liu yidao 
Published: June 2024

Abstract

Background
To investigate the influence of preoperative noninvasive indexes on surgical outcomes of benign prostatic hyperplasia (BPH) patients and to establish a clinical prediction model.
Methods
A total of 250 cases of BPH patients treated with transurethral resection of the prostate (TURP) in our center from December 2020 to June 2023 were included. The evaluation was completed by detailed history questionnaire, an international prostate symptom score (IPSS) assessment, and a urological ultrasonography.
Results
Among included patients, 185 had effective outcomes and 65 had ineffective outcomes, with an effective rate of 74%. Univariate and multivariate analyses identified international prostatic symptom score-voiding/storage subscore ratio (IPSS-V/S), postvoid residual urine ratio (PVR-R), disease duration, IPP, history of diabetes, history of urinary retention, as independent predictive factors of surgical outcomes, which were further subjected to construct the prediction model. Receiver operating characteristic curve indicated an area under curve of 0.894. The sensitivity and specificity of the model were 79.46% and 87.69%, respectively. Internal validation and the calibration curve indicated good agreement between the predicted outcome and the actual outcome. Clinical decision curves found that the model had a greater net clinical benefit than the "all-intervention" and "no-intervention" scenarios.
Conclusion
The results suggested that BPH patients with a shorter disease duration, a larger IPSS-V/S, a larger IPP, a smaller PVR-R, and no history of diabetes or urinary retention were more likely to have a better outcome after TURP.
Molecular beam epitaxial In2Te3 electronic devices
Authors: Yi Gyu-Chul , Kim Imhwan , Ryu Jinseok , Lee Eunsu , Lee Sangmin , Lee Seokje , Suh Wonwoo , Lee Jamin , Kim Miyoung , Oh Hongseok 
Published: June 2024

Abstract

We report on electrical characteristics of field-effect transistors (FETs) and Schottky diodes based on In2Te3 grown on hexagonal boron nitride (h-BN) substrates utilizing molecular beam epitaxy (MBE). A two-step growth method was used to enhance surface coverage and large grain sizes for high-quality In2Te3. Scanning transmission electron microscopy (STEM) imaging demonstrated an atomically clean and abrupt interface between the In2Te3 and h-BN substrates. The MBE-grown In2Te3 FETs exhibited superior electrical properties compared to previously reported In2Te3 FETs, including a mobility of 6.07 cm² V⁻¹ s⁻¹, a subthreshold swing close to 6 V dec⁻¹, and an impressive on/off ratio of about 10⁵. Furthermore, the Ti/In2Te3 Schottky diodes exhibits a low saturation current of 0.4 nA, an ideality factor of 26.7, and a Schottky barrier height of 0.68 eV.
Canine colorectal proliferative lesions: A retrospective study of 217 cases
Authors: Fiedorowicz Joanna , Czapula Katarzyna Paździor - , Domagała Iwona Otrocka - 
Published: June 2024

Abstract

Colorectal proliferative lesions are not common in dogs. However, recently we have observed an increase in the number of diagnosed cases and a lack of publications providing current epidemiological data on changes of the large intestine in dogs. The aim of this study was a retrospective analysis of 217 canine colorectal non-neoplastic and neoplastic tumours, and assessment of the frequency of occurrence of individual lesions and whether there is a risk of their occurrence depending on age, sex, or dogs breed. Histopathological diagnosis was based on routine staining (hematoxylin and eosin) and appropriate immunohistochemistry when was necessary for definitive diagnosis. Half of the cases (52.5%) were malignant tumours with male predisposition and a significant predominance of adenocarcinoma (42.9%). In the group of malignant non-epithelial lesions, lymphoma and sarcomas predominated (4.1% and 4.1%, respectively) followed by three cases of plasmacytoma. Benign neoplastic tumours constituted almost one-third of all cases (26.7%) with obvious dominance of adenoma (24.0%) and young male predisposition. Benign mesenchymal tumours were represented only by leiomyoma (2.8%). The non-neoplastic lesions were represented by a heterogeneous group of polyps (20.3%) with a slight advantage of hyperplastic type (9.7%) and less numerous inflammatory, fibroblastic, lymphoid, and hamartomatous polyps. The one case of ganglioneuromatosis in hamartomatous polyp was diagnosed. Non-neoplastic lesions were frequently diagnosed in female. We have observed for the first time that French Bulldogs are susceptible to developing colorectal proliferative lesions, including adenomas, adenocarcinomas and polyps. The results of our research provided new data expanding knowledge about the epidemiology of colorectal neoplastic and non-neoplastic proliferative lesion in dogs. We were also able to determine sex- and breed-specific risk factors associated with the occurrence of adenocarcinomas, adenomas, and non-neoplastic polyps. Our results are alarming and imply the necessity of implement routine colonoscopy in dogs in early detection of lesion and prevention of the development and progression of malignant tumours.
Investigating the Foaming Process of a Thermoplastic Elastomer (TPE) Using Rheology and Image Analysis
Authors: Kong Hyo Jae , Song Hyeong Yong , Lee Seung Hak , Lee Sumkun , Kim Gyungbok , Yun Nakyong , Hyun Kyu 
Published: June 2024

Abstract

This study introduced a method to simultaneously characterize time-resolved rheological and volumetric changes occurring during the foaming process of a thermoplastic elastomer containing an encapsulated physical blowing agent. For this, a conventional rotational rheometer was equipped with a commercial digital camera to capture video recordings. These video recordings were digitized into volumetric data using custom-written computer-vision-based algorithm. We firstly investigated rheological and volumetric changes during temperature ramp tests. The calculated cell volume fractions varied quantitatively depending on cell expansion and shrinkage. The viscoelastic moduli followed the characteristic behavior of the cell volume fraction. Furthermore, to analyze the volumetric changes under hypothetical processing conditions, a four-stage protocol comprising time sweep and temperature ramp was designed. The results revealed that the cell shrinkage induced by internal gas permeation at high temperatures was significantly greater than that induced by internal pressure reduction during cooling. Finally, comparison between foam densities computed using our algorithm and those measured using a densimeter revealed good agreement within 3% relative error. This demonstrates the applicability of our algorithm for quantitatively assessing volumetric changes of foam.
Comparison of the preoperative transpapillary unilateral biliary drainage methods for the future remnant liver in patients with hilar cholangiocarcinoma with liver resection: A retrospective cross-sectional study
Authors: Okuno Mitsuru , Iwata Keisuke , Iwashita Takuji , Mukai Tsuyoshi , Shimojo Kota , Ohashi Yosuke , Iwasa Yuhei , Senju Akihiko , Iwata Shota , Tezuka Ryuichi , Ichikawa Hironao , Mita Naoki , Uemura Shinya , Yoshida Kensaku , Maruta Akinori , Tomita Eiichi , Yasuda Ichiro , Shimizu Masahito 
Published: June 2024

Abstract

Background and Aims:
Transpapillary preoperative biliary drainage (PBD) only for the future remnant liver (FRL) in hilar cholangiocarcinoma (HCCA) can be performed minimally invasively, with the expectation of swelling of the FRL. However, verification of the appropriate transpapillary unilateral PBD method for FRL is limited since the cases of liver resection are insufficient.
Methods:
A total of 63 patients with resectable HCCA were evaluated. Twelve unilateral across-the-papilla plastic stent placement cases (PS group), 14 unilateral intraductal plastic stent placement cases (IS group), and 11 unilateral endoscopic nasobiliary drainage cases (ENBD group) met the inclusion criteria. Each group was compared regarding the hospital stay duration for the endoscopic procedure, recurrent biliary obstruction (RBO), time to RBO (TRBO), overall survival (OS), and surgical outcomes.
Results:
No significant differences were observed in the patient characteristics between the groups. Hospital stay for the endoscopic procedure was significantly longer in the ENBD group (50[33-163]days) than in the PS group (14[2-36]days; P<0.01) or IS group (21[6-118]days; P<0.01). There were no significant differences in the RBO, TRBO, OS, surgical time, amount of intraoperative blood loss, or post-surgical adverse events (AEs) between the groups. In the multivariate analysis, there were no significantly related factors for RBO, TRBO, OS, and post-surgical AEs.
Conclusions:
The PS, IS, and ENBD groups showed similar clinical outcomes in liver resection cases for HCCA, excluding the hospital stay duration for the endoscopic procedure. Considering the hospital stay duration, unilateral PS and IS placement can be considered acceptable for transpapillary PBD.
Clinical Trial Registration: UMIN000052598
Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection
Authors: Gon Hidetoshi , Komatsu Shohei , Soyama Hirotoshi , Tanaka Motofumi , Fukushima Kenji , Urade Takeshi , So Shinichi , Yoshida Toshihiko , Arai Keisuke , Ishida Jun , Nanno Yoshihide , Tsugawa Daisuke , Yanagimoto Hiroaki , Toyama Hirochika , Kido Masahiro , Fukumoto Takumi 
Published: June 2024

Abstract

Purpose
The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection.
Methods
Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan–Meier method.
Results
A total of 779 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 41 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 34% and 29% for the bile leak and no bile leak groups, respectively (P = 0.877). The 5-year overall survival rates were 45% and 52% for the bile leak and no bile leak groups, respectively (P = 0.360).
Conclusion
Overall, bile leak did not have a profound negative impact on the prognosis of patients included in this study. Proper management of bile leak could be attributed to reducing its negative impact on prognosis.
Influence of external load during back squats on knee joint arthrokinematics analyzed by vibroarthrography
Authors: Borzucka Dorota , Kręcisz Krzysztof , Bączkowicz Dawid 
Published: June 2024

Abstract

Background
This study aimed to use vibroarthrography to evaluate the effect of different external loads on the arthrokinematics of the patellofemoral joint during the back squat motion in vivo. The level of vibroarthrographic signal was expected to increase with the level of applied load; however, the trend of increase was unknown.
Methods
Participants, who were recruited from team sport athletes, were requested to perform eight trials: four bodyweight squats and four back-loaded barbell squats of 10–70 kg, with 1 min rest between tests. Finally, 38 male volunteers (age: 22.0 ± 1.1 years, body mass: 82.8 ± 10.1 kg, height: 186,7 ± 7.9 cm) were included in the study. All participants described their health condition as “very good.” An average physical activity of moderate-to-vigorous intensity, mostly aerobic, was considered as 12,47 ± 3,37 hours across the week. The arthrokinematic quality of movement of the PFJ was assessed using an accelerometer sensor placed 1 cm above the apex of the patella.
Results
The experimental results revealed that the vibroarthrographic signal level steadily increased with an increasing knee load during squatting, which could be attributed to higher contact stress and kinetic friction of the joint surfaces. The phenomenon was analyzed throughout the range of loads applied, which followed a linear pattern.
Conclusions
The proposed method is a promising tool for monitoring the effects of external loads on the knee joint mechanics and adaptive changes that occur during training. Moreover athletes and coaches should take into account that increased loads can result in accelerated joint wear and tear.