bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interaction of CuInS2/ZnS/TGA quantum dots with tyrosine kinase inhibitor and its application
Authors: Liao Shenghua , Huang Yu , Zuo Jiaxin , Yan Zhengyu 
Published: July 2014

AbstractThe interactions between thioglycolic acid‐capped‐CuInS2/ZnS quantum dots (CuInS2/ZnS/TGA QDs) and tyrosine kinase inhibitor (TKI) were investigated using fluorescence, ultraviolet–visible spectrometry and Fourier transform infrared spectrometry. The results indicated that the fluorescence intensity of CuInS2/ZnS/TGA could be quenched by imatinib, dasatinib, nilotinib, gefitinib and erlotinib, which hinted that CuInS2/ZnS/TGA QDs could be used in the detection of TKI in active pharmaceutical ingredients (API). Calibration curves showed good linear correlation and low detection limits. The average recovery was between 98 and 102%. Moreover, the nature of the fluorescence quenching mechanism of CuInS2/ZnS/TGA QDs by TKI was discussed. A ground state complex was formed by hydrogen bonding between the carboxyl group of CuInS2/ZnS/TGA QDs and the amino group of TKI. This led to an increase in non‐radiative transition and fluorescence quenching of CuInS2/ZnS/TGA QDs. Copyright © 2014 John Wiley & Sons, Ltd.
Improved Stability and Half‐Life of Fluorinated Phosphotriesterase Using Rosetta
Authors: Yang Ching‐Yao , Renfrew P. Douglas , Olsen Andrew J. , Zhang Michelle , Yuvienco Carlo , Bonneau Richard , Montclare Jin Kim 
Published: July 2014

AbstractRecently we demonstrated that incorporating p‐fluorophenylalanine (pFF) into phosphotriesterase dramatically improved folding, thereby leading to enhanced stability and function at elevated temperatures. To further improve the stability of the fluorinated enzyme, Rosetta was used to identify multiple potential stabilizing mutations. One such variant, pFF‐F104A, exhibited enhanced activity at elevated temperature and maintained activity over many days in solution at room temperature.
Buffer pKa and Transport Govern the Concentration Overpotential in Electrochemical Oxygen Reduction at Neutral pH
Authors: Popat Sudeep C. , Ki Dongwon , Young Michelle N. , Rittmann Bruce E. , Torres César I. 
Published: July 2014

AbstractMicrobial fuel cells (MFCs) show large cathodic overpotentials for the O2 reduction reaction. The local cathode pH is important, as OH− ions accumulate on the catalyst surface, resulting in a Nernstian concentration overpotential. Herein, we explore how various relevant buffers affect cathode performance at neutral pH, by reducing the concentration overpotential. We show that NH4+ buffer results in the best performance at current densities >10 A m−2, owing to buffering of the local pH close to its pKa (ca. 9.2). With other buffers, the local pH increases to >12 at similar current densities. We also show the importance of diffusion in buffer transport. Increasing the buffer concentration or improving the hydrodynamic conditions leads to lower overpotentials. We also present a mathematical model that includes buffer diffusion, for use in predicting cathode polarization curves. Overall, our results point to the promise of reducing cathode overpotentials in MFCs using naturally available buffers.
Rapid, Photocatalytic, and Deep Debromination of Polybrominated Diphenyl Ethers on Pd–TiO2: Intermediates and Pathways
Authors: Li Lina , Chang Wei , Wang Ying , Ji Hongwei , Chen Chuncheng , Ma Wanhong , Zhao Jincai 
Published: July 2014

AbstractTitanium dioxide with surface‐loaded palladium (Pd–TiO2) was able to easily remove all ten bromine atoms from decabromodiphenyl ether (BDE209) within 1 h under the irradiation of sunlight or an artificial light source. By contrast, fewer than three bromine atoms were eliminated on the pristine TiO2 even with prolonged irradiation (5 h). During the photocatalytic debromination, moreover, the formed BDE intermediates exhibited a significant difference between the Pd–TiO2 and pristine TiO2 systems, and much less position selectivity for the debromination on Pd–TiO2 was observed than that on the pristine TiO2 surface. For another polybrominated diphenyl ether (BDE15), pristine TiO2 was incapable of its photocatalytic reduction, whereas the loading of Pd enabled its debromination to diphenyl ether within 20 min. In addition, an evident induction period appeared in the photocatalytic debromination of BDE15 on Pd–TiO2. The experiments imply that the Pd‐cocatalyzed effect changes significantly the photocatalytic reductive debromination pathways.
Synthesis of 1‐Indanols and 1‐Indanamines by Intramolecular Palladium(0)‐Catalyzed C(sp3)H Arylation: Impact of Conformational Effects
Authors: Janody Simon , Jazzar Rodolphe , Comte Arnaud , Holstein Philipp M. , Vors Jean‐Pierre , Ford Mark J. , Baudoin Olivier 
Published: July 2014

AbstractA range of valuable 1‐indanols and 1‐indanamines containing a tertiary C1 atom were synthesized by intramolecular palladium(0)‐catalyzed C(sp3)H arylation, despite unfavorable steric interactions. The efficiency of the reaction was found to correlate with the degree of substitution at C2, as expected from the Thorpe–Ingold effect. Additionally, the nature of the heteroatomic substituent at C1 had a marked influence on the diastereoselectivity at C1 and C2; indeed, 1‐indanols and 1‐indanamines were obtained with the opposite relative configuration. Analysis of the X‐ray and DFT‐optimized structures of the corresponding reactive intermediates provided useful insights into the subtle conformational effects induced by these substituents.
Insights into the Asymmetric Heterogeneous Catalysis in Porous Organic Polymers: Constructing A TADDOL‐Embedded Chiral Catalyst for Studying the Structure–Activity Relationship[]
Authors: An Wan‐Kai , Han Man‐Yi , Wang Chang‐An , Yu Si‐Min , Zhang Yuan , Bai Shi , Wang Wei 
Published: July 2014

AbstractConstruction of porous organic polymers (POPs) as asymmetric catalysts remains as an important but challenging task. Herein, we exploit the “bottom‐up” strategy to facilely synthesize an α,α,α′,α′‐tetraaryl‐1,3‐dioxolane‐4,5‐dimethanol (TADDOL)‐based chiral porous polymer (TADDOL‐CPP) for highly efficient asymmetric catalysis. Constructed through the covalent linkages among the three‐dimensional rigid monomers, TADDOL‐CPP possesses hierarchical porous structure, high Brunauer–Emmett–Teller (BET) surface area, together with abundant and uniformly‐distributed chiral sites. In the presence of [Ti(OiPr)4], TADDOL‐CPP acts as a highly efficient and recyclable catalyst in the asymmetric addition of diethylzinc (Et2Zn) to aromatic aldehydes. Based on the direct observation of the key intermediates, the reaction mechanism has been revealed by solid‐state 13C magic‐angle spinning (MAS) NMR spectroscopy. In combination with the catalytic testing results, characterization on the working catalyst provides further information for understanding the structure–activity relationship. We suggest that the catalytic activity of TADDOL‐CPP is largely affected by the structural rigidity, cooperative catalysis, local chiral environment, and hierarchical porous framework. We expect that the information obtained herein will benefit to the designed synthesis of robust POP catalysts toward practical applications.
Liquid‐Phase Enantioselective Chromatographic Resolution Using Interpenetrated, Homochiral Framework Materials
Authors: Boer Stephanie A. , Nolvachai Yada , Kulsing Chadin , McCormick Laura J. , Hawes Chris S. , Marriott Philip J. , Turner David R. 
Published: July 2014

AbstractEffective separation of mixtures of enantiomers is of continuing interest in analytical and preparative chromatography, with new materials frequently designed and tested. We report two new enantiomerically pure 2D→3D interpenetrated materials used as stationary liquid chromatographic (LC) phases that are shown to resolve selected racemic mixtures with enantiomeric and chemical selectivity. Dicarboxylate ligands derived from amino acids on naphthalene and perylene cores form 2D frameworks that interpenetrate to give 3D structures. Selectivity is initially tested by uptake from solution; subsequent LC methods show that the materials exhibit resolution of racemic analytes in ‘micro‐columns’ and that the two closely related materials show markedly different selectivity for different analytes with much greater activity than the ligands alone. Comparison with a close‐packed analogue suggests that the separation activity is largely due to surface effects.
ChemInform Abstract: Ca54In13B4‐xH23+x: A Complex Metal Subhydride Featuring Ionic and Metallic Regions.
Authors: Blankenship Trevor V. , Chen Banghao , Latturner Susan E. 
Published: July 2014

AbstractCa54In13B4‐xH23+x (2.4 < x < 4) is prepared by solid state reactions of Ca, Li, In, B, and CaH2 in the molar ratio of 10:10:1:1:1, resp., using Ca and Li as a flux (stainless steel container in evacuated silica tube, 1050 °C, 2 h; controlled cooling).
ChemInform Abstract: Crystal Structures of Li6B4O9 and Li3B11O18 and Application of the Dimensional Reduction Formalism to Lithium Borates.
Authors: Rousse Gwenaelle , Baptiste Benoit , Lelong Gerald 
Published: July 2014

AbstractThe crystal structures of the title compounds are determined by single crystal XRD and Rietveld refinement of powder XRD data.
ChemInform Abstract: Control of the Superconducting Properties of Sr2‐xCaxVO3FeAs Through Isovalent Substitution.
Authors: Corkett Alex J. , Free David G. , Cassidy Simon J. , Ramos Silvia , Clarke Simon J. 
Published: July 2014

AbstractThe title compounds (0 ≤ x ≤ 0.5) are synthesized from stoichiometric mixtures of SrO, CaO, V, Fe2O3, Fe, and As (alumina crucibles, 1100 °C, 48 h).
ChemInform Abstract: Taking Advantage of Gold′s Electronegativity in R4Mn3‐xAu10+x (R: Gd or Y; 0.2 ≤ x ≤ 1).
Authors: Samal Saroj L. , Pandey Abhishek , Johnston David C. , Corbett John D. , Miller Gordon J. 
Published: July 2014

AbstractLn4Mn3‐xAu10+x (Ln: Gd, Y; 0.2 ≤ x ≤ 1) compounds are prepared by arc melting of stoichiometric amounts of the elements followed by annealing (Ta ampules in evacuated silica jackets, 1050 °C, 3—4 d).
ChemInform Abstract: Prediction of New Stable Compounds and Promising Thermoelectrics in the Cu—Sb—Se System.
Authors: Zhang Yongsheng , Ozolins Vidvuds , Morelli Donald , Wolverton C. 
Published: July 2014

AbstractPhase stabilities and a prediction of as yet unreported compounds are given for the title system on the basis of a combination of total energies from DFT calculations with vibrational entropies from phonon calculations within the harmonic approximation and configurational entropies treated with cluster expansions.
ChemInform Abstract: Ionic Conduction in Cubic Na3TiP3O9N, a Secondary Na‐Ion Battery Cathode with Extremely Low Volume Change.
Authors: Khalifah Peter , et al. et al. 
Published: July 2014

AbstractIsotropic mobility of Na at room temperature is demonstrated for Na3TiP3O9N which is prepared by solid state reaction of NaPO3, TiO2 (molar ratio of 3.05:1), and ascorbic acid (quartz boat, 850 °C, 20 h, flowing NH3).
ChemInform Abstract: Synthesis and Thermal Stability Studies of a Series of Metastable Dion—Jacobson Double‐Layered Neodymium‐Niobate Perovskites.
Authors: Josepha Elisha A. , Farooq Sara , Mitchell Cinnamon M. , Wiley John B. 
Published: July 2014

AbstractThe compounds (VI), (VIII), and (X) are prepared by topotactic ion exchange using (IV) as the precursor.
ChemInform Abstract: A Versatile and Highly Efficient Method for 1‐Chlorination of Terminal and Trialkylsilyl‐Protected Alkynes.
Authors: Gulia Nurbey , Pigulski Bartlomiej , Charewicz Marta , Szafert Slawomir 
Published: July 2014

AbstractAn efficient procedure for the chlorination of trialkylsilyl‐substituted alkynes is developed.
ChemInform Abstract: Highly Stereoselective Synthesis of 2‐Methyl‐1,3‐dienes by Palladium‐Catalyzed Cross‐Coupling Reaction with Trimethylaluminum.
Authors: Miyazawa Masahiro , Takehana Risa , Sanga Takao , Hosomori Aoi , Yokoyama Hajime , Hirai Yoshiro 
Published: July 2014

AbstractTreatment of bromodienes with trimethylaluminum in the presence of a palladium catalyst with tricyclohexylphosphine as ligand leads to geometrically pure methyl‐branched conjugated dienes.
ChemInform Abstract: Copper‐Catalyzed Z‐Selective Semihydrogenation of Alkynes with Hydrosilane: A Convenient Approach to cis‐Alkenes.
Authors: Wang Guang‐Hui , Bin Huai‐Yu , Sun Miao , Chen Shu‐Wei , Liu Ji‐Hong , Zhong Chong‐Min 
Published: July 2014

AbstractApplication of this method is demonstrated by the total synthesis of Combretastatin A‐4 (VII).
ChemInform Abstract: Direct C—H Arylations of Unactivated Arenes Catalyzed by Amido‐Functionalized Imidazolium Salts.
Authors: Ghosh Debalina , Lee Jhen‐Yi , Liu Chian‐Yu , Chiang Yen‐Hsin , Lee Hon Man 
Published: July 2014

AbstractAn effective organocatalytic system based on an amido‐functionalized imidazolium salt allows the synthesis of biaryls from arylhalides and benzene.
ChemInform Abstract: Palladium‐Catalyzed [2 + 2 + 1] Oxidative Annulation of 4‐Hydroxycoumarins with Unactivated Internal Alkynes: Access to Spiro Cyclopentadiene‐chroman‐2,4‐dione Complexes.
Authors: Peng Shiyong , Gao Tao , Sun Shaofa , Peng Yanhong , Wu Minghu , Guo Haibing , Wang Jian 
Published: July 2014

AbstractIn the presence of Cu(OAc)2 the title compounds are obtained while K2S2O8 promotes the formation of furan derivatives.
ChemInform Abstract: Stable Chiral Complexes of Ionic Liquids with Aluminium and Biaryl Ligands as Efficient Catalysts for the Synthesis of Chiral Lactones.
Authors: Drozdz Agnieszka , Foreiter Magdalena B. , Chrobok Anna 
Published: July 2014

AbstractThe asymmetric Baeyer‐Villiger oxidation of monosubstituted prochiral cyclobutanones to γ‐butyrolactones proceeds in the presence of aluminium complexes with biaryl ligands and ionic liquids.
ChemInform Abstract: Synthesis of 2‐Acylthiophenes by Palladium‐Catalyzed Addition of Thiophenes to Nitriles.
Authors: Jiang Tao‐Shan , Wang Guan‐Wu 
Published: July 2014

AbstractThe synthesis of 2‐acylthiophenes is accomplished by Pd‐catalyzed reaction of thiophenes with nitriles in the presence of (+)‐camphorsulfonic acid and water as hydrolysis reagents.
ChemInform Abstract: A Mild and Selective Pd‐Mediated Methodology for the Synthesis of Highly Fluorescent 2‐Arylated Tryptophans and Tryptophan‐Containing Peptides: A Catalytic Role for Pd0 Nanoparticles?
Authors: Williams Thomas J. , Reay Alan J. , Whitwood Adrian C. , Fairlamb Ian J. S. 
Published: July 2014

AbstractThe structures of products (IIId,e) are confirmed by X‐ray analysis.
ChemInform Abstract: Broensted Acid‐Catalyzed Straightforward Synthesis of Benzo[b]carbazoles from 2,3‐Unsubstituted Indoles.
Authors: Suarez Anisley , Garcia‐Garcia Patricia , Fernandez‐Rodriguez Manuel A. , Sanz Roberto 
Published: July 2014

AbstractAcid‐catalyzed condensation of indoles with ortho‐[α‐(hydroxy)benzyl]benzaldehyde acetals offers a straightforward synthesis of annulated carbazole derivatives.
ChemInform Abstract: Synthesis and Characterization of Some Novel Multisubstituted 6,7‐Dihydro‐5H‐cyclopenta[b]pyridine Derivatives.
Authors: Guerdere Meliha Burcu , Yilmaz Burhan , Budak Yakup 
Published: July 2014

AbstractA mild, efficient, and convenient method for the synthesis of the title compounds (II) from cheap and easily available starting materials is described.
ChemInform Abstract: Iron‐Catalyzed Chemo‐, Regio‐, and Stereoselective Hydrosilylation of Alkenes and Alkynes Using a Bench‐Stable Iron(II) Pre‐Catalyst.
Authors: Greenhalgh Mark D. , Frank Dominik J. , Thomas Stephen P. 
Published: July 2014

AbstractThe formed silanes can be further converted to alcohols and ketones by oxidation with H2O2.
ChemInform Abstract: Metal‐Free Oxidative Arylphosphination of Activated N‐Substituted‐N‐arylacrylamide Derivatives Using K2S2O8.
Authors: Li Ya‐Min , Shen Yuehai , Chang Kwen‐Jen , Yang Shang‐Dong 
Published: July 2014

AbstractOnly diphenylphosphine oxide reacts with acrylamides in the presence of K2S2O8.
ChemInform Abstract: New Cassane‐Type Diterpenoids of Caesalpinia echinata (Leguminosae) Exhibiting NF‐ϰB Inhibitory Activities.
Authors: Mitsui Taichi , Ishihara Risa , Hayashi Ken‐ichiro , Sunadome Mitsuhisa , Matsuura Nobuyasu , Nozaki Hiroshi 
Published: July 2014

AbstractEchinalides C (IIa) and D (IIb) significantly inhibit NF‐ϰB‐responsive reporter gene expression.
ChemInform Abstract: Suzuki Coupling Based Synthesis and in vitro Cytotoxic Evaluation of 7‐Heteroaryl‐Substituted Camptothecin Analogues.
Authors: Wang Lei , Huang Ying , Zhang Jie , Tong Linjiang , Chen Yi , Lu Wei , Huang Qingqing 
Published: July 2014

AbstractAll of the new compounds (IV) show potent inhibition of human tumor cell growth.
ChemInform Abstract: Lipoxygenase Inhibitors Derived from Marine Macroalgae.
Authors: Kurihara Hideyuki , Kagawa Yoshio , Konno Remi , Kim Sang Moo , Takahashi Koretaro 
Published: July 2014

AbstractThe alkapolyenes (I) and (II) show higher inhibitory activity than the known inhibitor nordihydroguaiaretic acid.
ChemInform Abstract: Asymmetric Epoxidation of Olefins with Homogeneous Chiral (Salen) Manganese(III) Complexes
Authors: Shi Qian‐Ping , Shi Zhi‐Hao , Li Nian‐Guang , Tang Yu‐Ping , Li Wei , Tang Hao , Zhang Wei , Shen Min‐Zhe , Duan Jin‐Ao 
Published: July 2014

AbstractReview: 138 refs.
ChemInform Abstract: Formation and Role of Palladium Chalcogenide and Other Species in Suzuki—Miyaura and Heck C—C Coupling Reactions Catalyzed with Palladium(II) Complexes of Organochalcogen Ligands: Realities and Speculations
Authors: Kumar Arun , Rao Gyandshwar Kumar , Kumar Satyendra , Singh Ajai K. 
Published: July 2014

AbstractReview: 174 refs.
Enzymatic Hydrolysis of Esters Containing a Tetrazole Ring
Authors: Łukowska‐Chojnacka Edyta , Mierzejewska Jolanta 
Published: July 2014

ABSTRACTThe lipase‐catalyzed enantioselective hydrolysis of acetates containing tetrazole moiety was studied. Among all tested lipases, Novozyme SP 435 allowed to obtain optically active 4‐(5‐aryl‐2H‐tetrazol‐2yl)butan‐2‐ol and 1‐(5‐aryl‐2H‐tetrazol‐2yl)‐propan‐2‐ol and their acetates with the highest optical purities (ee = 95%‐99%) and excellent enantioselectivity (E>100). Some of the synthesized tetrazole derivatives were screened for their antifungal activity. Racemic mixtures of 4‐[5‐(4‐chlorophenyl)‐2H‐tetrazol‐2‐yl)butan‐2‐ol as well as pure enantiomers of this compound showed promising antifungal activity against F. sambucinum, F. oxysporum, C. coccodes, and A. niger. Chirality 26: 811–816, 2014. © 2014 Wiley Periodicals, Inc.
Efficient multiple sources network coding signature in the standard model
Authors: Zhang Jinlin , Shao Jun , Ling Yun , Ji Min , Wei Guiyi , Ying Bishan 
Published: July 2014

SummaryNetwork coding is a new routing technique that can improve a network's throughput. The key idea is to allow network routers to code the received packets before transmission. However, network coding is vulnerable to pollution attacks where malicious node(s) can flood the network with invalid packets and prevent the receiver from the right decoding. Network coding signature offers a good solution to this problem. Nevertheless, existing network coding signature schemes cannot either be proven secure in the standard model, support multiple sources, or in‐time signing. In this paper, we propose a new network coding signature scheme to solve the aforementioned problems. Copyright © 2014 John Wiley & Sons, Ltd.
A First‐Principles Investigation on Microscopic Atom Distribution and Configuration‐Averaged Properties in Cd1−xZnxS Solid Solutions
Authors: Zhou Zhaohui , Shi Jinwen , Wu Po , Guo Liejin 
Published: July 2014

AbstractThe structural, energetic, and electronic properties of zincblende and wurtzite phase Cd1−xZnxS (0≤x≤1) solid solutions were investigated by first‐principles calculations. It was revealed that the trend of atom distribution in configurations with the same x value can be quantitatively characterized by the average length of the ZnS bonds. The origin of this trend was attributed to the strong interaction of the ZnS bonds, which acted against the aggregation of Zn atoms in this solid solution. By using a configuration‐averaged method, structural and energetic properties were estimated as a function of Zn content at the level of the generalized gradient approximation, whereas electronic properties were corrected by using a hybrid functional. Phase diagrams of both solid solutions were established. An optimal x value of approximately 0.5 for photocatalytic hydrogen production was determined by taking both the band edges and band gaps into consideration; this conclusion was supported by the results of a variety of experiments.
GLP‐1 receptor agonists: effects on the progression of non‐alcoholic fatty liver disease
Authors: Liu Jia , Wang Guang , Jia Yumei , Xu Yuan 
Published: July 2014

SummaryNon‐alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, and its incidence has been increasing recently. In addition to hepatic complications, NAFLD is also recognized as an independent risk factor for cardiovascular disease. Unfortunately, the current therapies for NAFLD display variable efficacy; a novel and effective drug is urgently needed. Glucagon‐like peptide‐1 (GLP‐1), a receptor agonist is a new drug approved for treating type 2 diabetes. Recently, these types of agents have shown a novel therapeutic effect on NAFLD. However, the mechanisms of GLP‐1 receptor agonists on the treatment of NAFLD have not yet been explained precisely. Recent studies have demonstrated that GLP‐1 reverses the progression of NAFLD not only indirectly through an incretin effect that improves key parameters involved in NAFLD, but also a direct effect on lipid metabolism of hepatocytes and inflammation in liver. In this review, we provided an overview of the role and mechanisms of GLP‐1 in the therapy of NAFLD. Copyright © 2014 John Wiley & Sons, Ltd.
Advanced complicated diabetes mellitus is associated with a reduced risk of thoracic and abdominal aortic aneurysm rupture: a population‐based cohort study
Authors: Tsai Chung‐Lin , Lin Cheng‐Li , Wu Yi‐Ying , Shieh Dong‐Chen , Sung Fung‐Chang , Kao Chia‐Hung 
Published: July 2014

AbstractBackgroundStudies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity.MethodsWe identified 160 391 patients with type 2 DM diagnosed from 1998 to 2008 and 646 710 comparison subjects without DM, frequency matched by diagnosis date, sex and age (mainly the elderly). The DM severity was partitioned into advanced and uncomplicated status according to DM‐related comorbidities.ResultsBy the end of 2010, the overall pooled incidence rate of thoracic aortic aneurysm and abdominal aortic aneurysm was 15% lower in the type 2 DM cohort than in non‐DM cohort, with an adjusted hazard ratio of 0.64 [95% confidence interval (CI) 0.56–0.74] in the multivariable Cox model. Patients with advanced type 2 DM were significantly associated with reduced thoracic aortic aneurysm rupture and abdominal aortic aneurysm without rupture, with adjusted hazard ratios of 0.50 (95% CI 0.35–0.71) and 0.53 (95% CI 0.40–0.69), respectively. Uncomplicated type 2 DM was also associated with reduced abdominal aortic aneurysm without rapture (aHR = 0.58, 95% CI 0.45–0.74).ConclusionsOur results demonstrate that patients with diabetes in this Asian population have reduced prevalence of thoracic and abdominal aortic aneurysms. The observed paradoxical inverse relationship between severity of DM and aortic aneurysms is clear. Further research is required to investigate the underlying mechanisms for the reduced risk of aortic aneurysms associated with diabetes. Copyright © 2014 John Wiley & Sons, Ltd.