bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter — Determining Validation Requirements
Authors: Humby Frances , Kelly Stephen , Bugatti Serena , Manzo Antonio , Filer Andrew , Mahto Arti , Fonseca Joao Eurico , Lauwerys Bernard , D’Agostino Maria-Antonietta , Naredo Esperanza , Lories Rik , Montecucco Carlomaurizio , Tak Paul Peter , Fitzgerald Oliver , Smith Malcolm D. , Veale Douglas J. , Choy Ernest H. , Strand Vibeke , Pitzalis Costantino 
Published: June 2015

Objective.Because limited data currently support the clinical utility of peripherally expressed biomarkers in guiding treatment decisions for patients with rheumatoid arthritis, the search has turned to the disease tissue. The strategic aim of the Outcome Measures in Rheumatology (OMERACT) synovitis working group over the years has been to develop novel diagnostic and prognostic synovial biomarkers. A critical step in this process is to refine and validate minimally invasive, technically simple, robust techniques to sample synovial tissue, for use both in clinical trials and routine clinical practice. The objective of the synovitis working group (SWG) at OMERACT 12 (2014) was to examine whether recently developed ultrasound (US)-guided synovial biopsy techniques could be validated according to the OMERACT filter for future clinical use recommendation.MethodsThe SWG examined whether current data reporting US-guided synovial biopsy of both large and small joints addressed the OMERACT filters of truth, discrimination, and feasibility.Results.There are currently limited data examining the performance of US-guided synovial biopsy, mainly from observational studies. Thus, it remains critical to evaluate its performance, within the clinical trials context, against the current gold standard of arthroscopic biopsy, with particular reference to: (1) synovial tissue yield, (2) capacity to determine treatment response as measured by a validated synovial biomarker, and (3) tolerability of the procedure.Conclusion.We summarize the discrete work packages agreed to as requirements to validate US-guided synovial biopsy and therefore lead to a global consensus on the use of synovial biopsy for research and clinical practice.
Knee Pain and a Prior Injury Are Associated with Increased Risk of a New Knee Injury: Data from the Osteoarthritis Initiative
Authors: Driban Jeffrey B. , Lo Grace H. , Eaton Charles B. , Price Lori Lyn , Lu Bing , McAlindon Timothy E. 
Published: June 2015

Objective.We explored whether knee pain or a history of knee injury were associated with a knee injury in the following 12 months.Methods.We conducted longitudinal knee-based analyses among knees in the Osteoarthritis Initiative. We included both knees of all participants who had at least 1 followup visit with complete data. Our first sets of exposures were knee pain (chronic knee symptoms and severity) at baseline, 12-month, 24-month, and 36-month visits. Another exposure was a history of injury that we defined as a self-reported injury at any time prior to baseline, 12-month, 24-month, or 36-month visit. The outcome was self-reported knee injury during the past year at 12-month, 24-month, 36-month, and 48-month visits. We evaluated the association between ipsilateral and contralateral knee pain or history of injury and a new knee injury within 12 months of the exposure using generalized linear mixed model for repeated binary outcomes.Results.A knee with reported chronic knee symptoms or ipsilateral or contralateral history of an injury was more likely to experience a new knee injury in the following 12 months than a knee without chronic knee symptoms (OR 1.84, 95% CI 1.57–2.16) or prior injury (prior ipsilateral knee injury: OR 1.81, 95% CI 1.56–2.09. Prior contralateral knee injury: OR 1.43, 95% CI 1.23–1.66).Conclusion.Knee pain and a history of injury are associated with new knee injuries. It may be beneficial for individuals with knee pain or a history of injury to participate in injury prevention programs.
La thèse humboldtienne de l’ individualité de la langue
Authors: Borsche Tilman , Gendre Frédéric 
Published: June 2015

Cet article propose un éclairage de la notion humboldtienne de langue comme individualité spirituelle. Il dessine l’arrière-plan historique et philosophique de la notion d’individualité sur lequel la pensée de Humboldt se fonde, mais se détache également. Comment penser une langue (particulière) sur fond de langues multiples aux identités propres et aux variations parfois très grandes ? Quels sont leurs rapports ? Le recours à la notion d’organisme vivant pour décrire la langue, inséparable des usages et des pratiques qui s’y attachent, permet d’envisager aussi bien les langues particulières que la langue en général (cette faculté proprement humaine) comme liées par un dynamisme. Plus que des objets naturels, les langues sont des êtres-reconnus (c’est-à-dire pratiqués), leur identité comme leur dynamisme est inséparable d’une dimension spirituelle. Ce qui en fait des objets complexes puisant aussi bien dans le vitalisme que dans les formes symboliques.
De l’anthropologie parisienne aux langues du Nouveau Continent
Authors: Trabant Jürgen 
Published: June 2015

L’article esquisse le chemin de Wilhelm von Humboldt d’une anthropologie de la culture européenne et parisienne vers une science des langues du Nouveau Continent et des langues du monde entier. Un des premiers textes qui expose le projet d’une étude comparée des langues est l’Essai sur les langues du Nouveau Continent , écrit en français, dans lequel Humboldt explique les buts philosophiques d’une étude des langues : elle s’inscrit très clairement dans une perspective leibnizienne d’une étude de l’esprit humain dans sa variété : Les langues sont des « visions » ( Ansichten ) individuelles du monde. Humboldt lutte contre la vieille conception sémiotico-communicative et pour une conception cognitive du langage et des langues.
Humboldt et l’Orient. Confrontation des interprétations de Humboldt et de Hegel de la Bhagavad-Gîta
Authors: Quillien Jean 
Published: June 2015

L’Orient exerça une forte attirance au tournant des XVIII e et XIX e siècles, avec la mise au premier plan du sanscrit. Deux penseurs contemporains, Hegel et Humboldt, le premier à travers la recension d’une étude du second, s’opposèrent nettement sur la question de la signification du monde oriental. Pour Hegel il est la première étape, produit encore enfantin, de l’histoire mondiale, que traduit si bien la Bhagavad-Gîta. Pour Humboldt, l’I nde a son sens authentiquement humain en elle-même et ce grand poème du Mahabharata est une œuvre d’art universelle. L’un considère comme essentiel le contenu, l’autre la forme, en laquelle seule réside l’art.
Les éléments kantiens dans la philosophie du langage de Wilhelm von Humboldt*
Authors: Cassirer Ernst , Djian Aurélien 
Published: June 2015

Dans ce texte de 1923, Cassirer cherche à réaliser le programme échafaudé par Haym dans sa biographie de Humboldt publiée en 1856, mais qui n’a selon lui jamais été accompli dans le détail, à savoir montrer l’influence du système critique de Kant, et notamment de sa Critique de la raison pure , sur la philosophie du langage de Wilhelm von Humboldt. La première partie expose l’objection qui ne manque pas d’être spontanément soulevée à la vue d’un tel projet. Dans le système critique, organisé autour des deux centres de la nature et de la liberté, il n’y a en effet pas de place pour le langage. Une telle situation apparaît d’ailleurs surprenante lorsque, comme le fait la seconde partie de ce texte, on place la Critique à côté des grands systèmes philosophiques des XVI e, XVII e et XVIII e siècles, où le langage constituait un thème important. En quoi la Critique de Kant, éloignée des problèmes du langage, pourrait-elle dès lors avoir une influence véritable sur Humboldt ? La réponse vient une fois la place de Humboldt définie dans cette reconstruction historique. En effet, sa philosophie du langage résout précisément le conflit entre Kant et son idéalisme critique d’un côté, et Herder et sa conception de la vie et de la spontanéité de l’esprit de l’autre. La troisième partie tente dès lors de montrer à quel point cet idéalisme critique – notamment par le biais de son motif transcendantal, comprenant un nouveau concept d’objet, d’objectivité et de sujet, et de sa paire matière/forme – travaille de manière souterraine la philosophie du langage de Humboldt, ce qui aboutit en retour à réévaluer la place de la Critique dans l’histoire des problèmes du langage.
« La voix d’une brise légère »
Authors: Balmand Pascal 
Published: June 2015

À la fois clairement ancré dans l’Église et largement ouvert à tous, l’Enseignement catholique constitue un lieu particulièrement sensible à la question de la possibilité d’une parole chrétienne dans un milieu qui ne l’est pas totalement. Pourquoi la langue catholique de l’institution peine-t-elle à parler à tous ses acteurs ? Et, surtout, comment trouver la voie d’une voix audible ? Peut-être autour de cinq critères : une parole nourrie de l’écoute, une parole-conversation, une parole capable d’assumer sa propre fragilité, une parole habitée, une parole portée par la Parole.
Justice et charité dans l’encyclique Caritas in veritate à la lumière de Gaston Fessard (1897-1978)
Authors: Serra-Coatanéa Dominique 
Published: June 2015

Relire cette encyclique de Benoît XVI avec l’apport du jésuite G. Fessard donne d’étonnants résultats. Les bases théologales apparaissent plus nettement. Les débouchés anthropologiques sont plus riches. L’action morale conduite par la charité se fait plus pressante. Fessard met au point une tension dialectique au profit d’une meilleure compréhension de la doctrine sociale. La reprise de la révélation biblique chez Fessard est un lieu de passage inéludable. Il est possible aussi d’interroger, grâce à Fessard, la mondialisation actuelle et d’envisager une gradualité de notre marche vers la perfection de la charité. L’enseignement de Populorum Progressio (Paul VI) et de Centesimus annus (Jean-Paul II) se trouve valorisé par la lecture fessardienne.
A Model of Global Cooperation to Enable Intelligent Metrology Applications by Means of an Integrated Teleoperation System
Authors: Durakbasa Numan , Bas Gokcen , Riepl David , Bauer J. M. 
Published: June 2015

Today’s advanced production industry faces challenges of increasing quality and competition requirements in the global market. The new aspects of cooperation between the production industry and metrology laboratories enable a development capacity providing an information highway and expertise exchange by accommodating rising demand of services. This paper proposes a novel approach to develop a global network on two different continents that will moreover be a model for the industry without any limits of location, time difference or facility.
Due to the high cost of special infrastructure, equipment and expertise for production of complex components, this study also proposes a strategic approach to develop a remotely controlled high precision metrology system with high accuracy as well as with the smallest measurement uncertainties for the micro- and nanotechnologies and intelligent integrated management system applicable in advanced manufacturing industry. This will provide a roadmap for the industrial applications as well as in educational organizations with the developed and integrated low-cost telepresence and teleoperation system.
Seven Q-Tracks Monitors of Laboratory Quality Drive General Performance Improvement: Experience From the College of American Pathologists Q-Tracks Program 1999–2011
Authors: Meier Frederick A. , Souers Rhona J. , Howanitz Peter J. , Tworek Joseph A. , Perrotta Peter L. , Nakhleh Raouf E. , Karcher Donald S. , Bashleben Christine , Darcy Teresa P. , Schifman Ron B. , Jones Bruce A. 
Published: June 2015

ContextMany production systems employ standardized statistical monitors that measure defect rates and cycle times, as indices of performance quality. Clinical laboratory testing, a system that produces test results, is amenable to such monitoring.ObjectiveTo demonstrate patterns in clinical laboratory testing defect rates and cycle time using 7 College of American Pathologists Q-Tracks program monitors.DesignSubscribers measured monthly rates of outpatient order-entry errors, identification band defects, and specimen rejections; median troponin order-to-report cycle times and rates of STAT test receipt-to-report turnaround time outliers; and critical values reporting event defects, and corrected reports. From these submissions Q-Tracks program staff produced quarterly and annual reports. These charted each subscriber's performance relative to other participating laboratories and aggregate and subgroup performance over time, dividing participants into best and median performers and performers with the most room to improve. Each monitor's patterns of change present percentile distributions of subscribers' performance in relation to monitoring durations and numbers of participating subscribers. Changes over time in defect frequencies and the cycle duration quantify effects on performance of monitor participation.ResultsAll monitors showed significant decreases in defect rates as the 7 monitors ran variously for 6, 6, 7, 11, 12, 13, and 13 years. The most striking decreases occurred among performers who initially had the most room to improve and among subscribers who participated the longest. All 7 monitors registered significant improvement. Participation effects improved between 0.85% and 5.1% per quarter of participation.ConclusionsUsing statistical quality measures, collecting data monthly, and receiving reports quarterly and yearly, subscribers to a comparative monitoring program documented significant decreases in defect rates and shortening of a cycle time for 6 to 13 years in all 7 ongoing clinical laboratory quality monitors.
Autologous Hematopoietic Stem Cell Transplantation—10 Years of Data From a Developing Country
Authors: Ali Natasha , Adil Salman Naseem , Shaikh Mohammad Usman 
Published: June 2015

Abstract

Intensive chemotherapy followed by autologous stem cell transplantation is the treatment of choice for patients with hematological malignancies. The objective of the present study was to evaluate the outcomes of patients with mainly lymphoma and multiple myeloma after autologous stem cell transplant. The pretransplant workup consisted of the complete blood count, an evaluation of the liver, kidney, lung, and infectious profile, chest radiographs, and a dental review. For lymphoma, all patients who achieved at least a 25% reduction in the disease after salvage therapy were included in the study. Mobilization was done with cyclophosphamide, followed by granulocyte colony-stimulating factor, 300 µg twice daily. The conditioning regimens included BEAM (carmustine, etoposide, cytarabine, melphalan) and high-dose melphalan. A total of 206 transplants were performed from April 2004 to December 2014. Of these, 137 were allogeneic transplants and 69 were autologous. Of the patients receiving an autologous transplant, 49 were male and 20 were female. Of the 69 patients, 26 underwent transplantation for Hodgkin's lymphoma, 23 for non-Hodgkin's lymphoma, and 15 for multiple myeloma and 4 and 1 for Ewing's sarcoma and neuroblastoma, respectively. The median age ± SD was 34 ± 13.1 years (range, 4–64). A mean of 4.7 × 108 ± 1.7 mononuclear cells per kilogram were infused. The median time to white blood cell recovery was 18.2 ± 5.34 days. Transplant-related mortality occurred in 10 patients. After a median follow-up period of 104 months, the overall survival rate was 86%. High-dose chemotherapy, followed by autologous stem cell transplant, is an effective treatment option for patients with hematological malignancies, allowing further consolidation of response.

Significance
This report presents the results of autologous stem cell transplant in hematological malignancies from a developing country. This is a large cohort from Pakistan, with overall survival comparable to that from international data.
On the control of riverbed incision induced by run‐of‐river power plant
Authors: Bizzi Simone , Dinh Quang , Bernardi Dario , Denaro Simona , Schippa Leonardo , Soncini‐Sessa Rodolfo 
Published: June 2015

AbstractWater resource management (WRM) through dams or reservoirs is worldwide necessary to support key human‐related activities, ranging from hydropower production to water allocation and flood risk mitigation. Designing of reservoir operations aims primarily to fulfill the main purpose (or purposes) for which the structure has been built. However, it is well known that reservoirs strongly influence river geomorphic processes, causing sediment deficits downstream, altering water, and sediment fluxes, leading to riverbed incision and causing infrastructure instability and ecological degradation. We propose a framework that, by combining physically based modeling, surrogate modeling techniques, and multiobjective (MO) optimization, allows to include fluvial geomorphology into MO optimization whose main objectives are the maximization of hydropower revenue and the minimization of riverbed degradation. The case study is a run‐of‐the‐river power plant on the River Po (Italy). A 1‐D mobile‐bed hydro‐morphological model simulated the riverbed evolution over a 10 year horizon for alternatives operation rules of the power plant. The knowledge provided by such a physically based model is integrated into a MO optimization routine via surrogate modeling using the response surface methodology. Hence, this framework overcomes the high computational costs that so far hindered the integration of river geomorphology into WRM. We provided numerical proof that river morphologic processes and hydropower production are indeed in conflict but that the conflict may be mitigated with appropriate control strategies.
Ecohydrological modeling in agroecosystems: Examples and challenges
Authors: Porporato A. , Feng X. , Manzoni S. , Mau Y. , Parolari A. J. , Vico G. 
Published: June 2015

AbstractHuman societies are increasingly altering the water and biogeochemical cycles to both improve ecosystem productivity and reduce risks associated with the unpredictable variability of climatic drivers. These alterations, however, often cause large negative environmental consequences, raising the question as to how societies can ensure a sustainable use of natural resources for the future. Here we discuss how ecohydrological modeling may address these broad questions with special attention to agroecosystems. The challenges related to modeling the two‐way interaction between society and environment are illustrated by means of a dynamical model in which soil and water quality supports the growth of human society but is also degraded by excessive pressure, leading to critical transitions and sustained societal growth‐collapse cycles. We then focus on the coupled dynamics of soil water and solutes (nutrients or contaminants), emphasizing the modeling challenges, presented by the strong nonlinearities in the soil and plant system and the unpredictable hydroclimatic forcing, that need to be overcome to quantitatively analyze problems of soil water sustainability in both natural and agricultural ecosystems. We discuss applications of this framework to problems of irrigation, soil salinization, and fertilization and emphasize how optimal solutions for large‐scale, long‐term planning of soil and water resources in agroecosystems under uncertainty could be provided by methods from stochastic control, informed by physically and mathematically sound descriptions of ecohydrological and biogeochemical interactions.
Bildung von GaN‐Schichten auf Saphir durch Niedertemperatur‐Pufferschichten und Erzeugung von p‐GaN durch Magnesium‐Dotierung und Elektronenbeschuss (Nobel‐Aufsatz)
Authors: Amano Hiroshi 
Published: June 2015

AbstractDieser Aufsatz ist eine persönliche Schilderung der Forschungsarbeiten, die zur Entwicklung einer Methode zur Kristallzüchtung von Galliumnitrid (GaN) auf einem Saphir‐Substrat führten. Die Ergebnisse bereiteten den Weg für die Entwicklung von smarten Anzeigesystemen auf der Basis blauer LEDs. Die wichtigsten Arbeiten wurden Mitte bis Ende der 80er Jahre durchgeführt. Die Hintergründe der Arbeiten des Autors und die Ereignisse, die in der Technologie für die GaN‐Züchtung und die Erzeugung von p‐GaN resultierten, werden zusammengefasst.
Sensitivity analysis for selection of an optimum amine gas sweetening process with minimum cost requirement
Authors: Sharif Dashti Sajjad , Shariati Ahmad , Khosravi Nikou Mohammad Reza 
Published: June 2015

AbstractOne of the most commonly used processes for the removal of acid gases from natural gas is absorption in alkanolamine‐based solvents. Operating cost and energy consumption beside environmental cares are the main limiting factors, which lead process designers to select optimum values of sensitive parameters in sweetening plants. This paper summarizes a study that determines values of optimum operating parameters for sweetening a sour gas stream with 5 mol% of CO2 and 0.39 mol% of H2S considering optimum cost and energy consumption. A typical amine sweetening process plant is used to accomplish a steady–state simulation by HYSYS process simulator v8.4 using different amine solutions, i.e. single, mixed, and also activated amines. It also examined some of the important amine process parameters for each amine type such as amine circulation rate, lean amine temperature, corrosion and amine loss considerations. Finally, an economic evaluation is performed by Aspen process economic analyzer to compare operational and total capital costs of processes. It has been revealed that mixture of methyldiethanolamine and dieathanolamine is more applicable due to its higher absorption capacity, lower capital and operational expenditure, and lower costs related to corrosion and amine losses. © 2015 Curtin University of Technology and John Wiley & Sons, Ltd.
A G/G(n)/C/C state‐dependent simulation model for metro station corridor width design
Authors: Jiang Yangsheng , Zhu Juanxiu , Hu Lu , Lin Xi , Khattak Afaq 
Published: June 2015

SummaryMetro station corridor and passengers are described as a G/G(n)/C/C state‐dependent queuing system with a general random arrival interval G and a general random and state‐dependent service time G(n) to offset the shortcomings in existing design methods. The corresponding G/G(n)/C/C state‐dependent discrete event simulation model is developed, and its high‐fidelity is tested. Then the optimization algorithm based on the simulation model is designed to determine corridor width. The proposed simulation optimization method and the existing analytical optimization methods, based on M/G(n)/C/C and D/D/1/C queuing models, are applied to design corridor width in a numerical example of 48 combinations of passenger flow rates and level of service (LOS). The designed corridor widths are tested in a micro‐simulation model, and the performance measure is compared. The result shows that the corridor widths obtained by the new method are 0.357 m (7.4%) larger than that of the other two methods on average; the area per passenger of the new method increases 10.53% and 11.63%, respectively, compared with that of the other two methods; the widths designed by the new method satisfy the requirement of LOS under various passenger flows, whereas 93% of the corridor widths obtained by the other two methods fail to meet the requirement of LOS, and the corridor widths designed by the new method have high elasticity coefficients of LOS‐width. Copyright © 2015 John Wiley & Sons, Ltd.