bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passivation of aluminium–n+ silicon contacts for solar cells by ultrathin Al2O3 and SiO2 dielectric layers
Authors: Bullock James , Yan Di , Cuevas Andrés 
Published: August 2013

AbstractUltra‐thin thermally grown SiO2 and atomic‐layer‐deposited (ALD) Al2O3 films are trialled as passivating dielectrics for metal–insulator–semiconductor (MIS) type contacts on top of phosphorus diffused regions applicable to high efficiency silicon solar cells. An investigation of the optimum insulator thickness in terms of contact recombination factor J0_cont and contact resistivity ρc is undertaken on 85 Ω/□ and 103 Ω/□ diffusions. An optimum ALD Al2O3 thickness of ∼22 Å produces a J0_cont of ∼300 fAcm–2 whilst maintaining a ρc lower than 1 mΩ cm2 for the 103 Ω/□ diffusion. This has the potential to improve the open‐circuit voltage by a maximum 15 mV. The thermally grown SiO2 fails to achieve equivalently low J0_cont values but exhibits greater thermal stability, resulting in slight improvements in ρc when annealed for 10 minutes at 300 °C without significant changes in J0_cont. The after‐anneal J0_cont reaches ∼600 fAcm–2 with a ρc of ∼2.5 mΩ cm2 for the 85 Ω/□ diffusion amounting to a maximum gain in open‐circuit voltage of 6 mV. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Latent class models for medical diagnostic tests in multicenter trials
Authors: Mori Joji , Kano Yutaka , Yoshizaki Masahiro , Fukinbara Satoru 
Published: August 2013

AbstractMedical diagnostic tests must enjoy appropriate validity and high reliability in order to qualify as adequate assessment tools. Without a gold standard test, available medical diagnostic tests are not perfect; hence, the reliability of such tests must be evaluated precisely. Kappa coefficient statistics are often utilized to assess reliability of tests when there are two or more medical diagnostic tests. However, the statistics are imprecise for a typical case when the prevalence rate of a target disease is unknown. Although latent class models could be used to assess reliability, the models cannot estimate reliability in the case of two tests, due to unidentifiability or the lack of degrees of freedom. An alternative approach to assess reliability for the case of two tests is stratifying a two‐by‐two contingency table under the assumption that sensitivities and specificities between the two tests be equal over all strata and that prevalence rates in the strata be different from each other. Because stratification is basically a multi‐sample analysis, it should not be applied to the situation where subsamples (i.e., centers) are randomly selected from a larger population. In this article, a type of mixed‐effect model is proposed to evaluate the reliability of two tests for trials in randomly selected multiple centers. Several types of distributions for prevalence rates over subpopulations are considered. Simulation studies show that our proposed method performs nicely. Analysis of real data is also reported. Copyright © 2013 John Wiley & Sons, Ltd.
Extended comprehensive study of association measures for fault localization
Authors: Lucia Lucia , Lo David , Jiang Lingxiao , Thung Ferdian , Budi Aditya 
Published: August 2013

ABSTRACTSpectrum‐based fault localization is a promising approach to automatically locate root causes of failures quickly. Two well‐known spectrum‐based fault localization techniques, Tarantula and Ochiai, measure how likely a program element is a root cause of failures based on profiles of correct and failed program executions. These techniques are conceptually similar to association measures that have been proposed in statistics, data mining, and have been utilized to quantify the relationship strength between two variables of interest (e.g., the use of a medicine and the cure rate of a disease). In this paper, we view fault localization as a measurement of the relationship strength between the execution of program elements and program failures. We investigate the effectiveness of 40 association measures from the literature on locating bugs. Our empirical evaluations involve single‐bug and multiple‐bug programs. We find there is no best single measure for all cases. Klosgen and Ochiai outperform other measures for localizing single‐bug programs. Although localizing multiple‐bug programs, Added Value could localize the bugs with on average smallest percentage of inspected code, whereas a number of other measures have similar performance. The accuracies of the measures in localizing multi‐bug programs are lower than single‐bug programs, which provokes future research. Copyright © 2013 John Wiley & Sons, Ltd.
Towards a hybrid testing process unifying exploratory testing and scripted testing
Authors: Shah Syed Muhammad Ali , Gencel Cigdem , Alvi Usman Sattar , Petersen Kai 
Published: August 2013

SUMMARYGiven the current state of the art in research, practitioners are faced with the challenge of choosing scripted testing (ST) or exploratory testing (ET). This study aims at systematically incorporating strengths of ET and ST in a hybrid testing process to overcome the weaknesses of each. We utilized systematic review and practitioner interviews to identify strengths and weaknesses of ET and ST. Strengths of ET were mapped to weaknesses of ST and vice versa. Noblit and Hare's lines‐of‐argument method was used for data analysis. The results of the mapping were used as input to codesign a hybrid process with experienced practitioners. We found a clear need to create a hybrid process as follows: (i) both ST and ET provide strengths and weaknesses, and these depend on some particular conditions, which prevents preference of one approach to another; and (ii) the mapping showed that it is possible to address the weaknesses in one process by the strengths of the other in a hybrid form. With the input from literature and industry experts, a flexible and iterative hybrid process was designed. Practitioners can clearly benefit from using a hybrid process given the mapping of advantages and disadvantages. Copyright © 2013 John Wiley & Sons, Ltd.
High‐resolution station‐based diurnal ionospheric total electron content (TEC) from dual‐frequency GPS observations
Authors: Çepni Murat S. , Potts Laramie V. , Miima John B. 
Published: August 2013

AbstractTotal electron content (TEC) estimates derived from Global Navigation Satellite System (GNSS) signal delays provide a rich source of information about the Earth's ionosphere. Networks of Global Positioning System (GPS) receivers data can be used to represent the ionosphere by a Global Ionospheric Map (GIM). Data input for GIMs is dual‐frequency GNSS‐only or a mixture of GNSS and altimetry observations. Parameterization of GNSS‐only GIMs approaches the ionosphere as a single‐layer model (SLM) to determine GPS TEC models over a region. Limitations in GNSS‐only GIM TEC are due largely to the nonhomogenous global distribution of GPS tracking stations with large data gaps over the oceans. The utility of slant GPS ionospheric‐induced path delays for high temporal resolution from a single‐station data rate offers better representation of TEC over a small region. A station‐based vertical TEC (TECV) approach modifies the traditional single‐layer model (SLM) GPS TEC method by introducing a zenith angle weighting (ZAW) filter to capture signal delays from mostly near‐zenith satellite passes. Comparison with GIMs shows the station‐dependent TEC (SD‐TEC) model exhibits robust performance under variable space weather conditions. The SD‐TEC model was applied to investigate ionospheric TEC variability during the geomagnetic storm event of 9 March 2012 at midlatitude station NJJJ located in New Jersey, USA. The high temporal resolution TEC results suggest TEC production and loss rate differences before, during, and after the storm.
Nitrogen regulation involved in the accumulation of urea in Saccharomyces cerevisiae
Authors: Zhao Xinrui , Zou Huijun , Fu Jianwei , Chen Jian , Zhou Jingwen , Du Guocheng 
Published: August 2013

AbstractRice wine is a popular traditional alcoholic drink with a long history in China. However, the presence of the potential carcinogen ethyl carbamate (EC) raises a series of food safety concerns. Although the metabolic pathway of urea (the major precusor of EC) has been characterized in Saccharomyces cerevisiae, the regulation of urea accumulation remains unclear, making the efficient elimination of urea difficult. To demonstrate the regulatory mechanisms governing urea accumulation, three key nitrogen sources that can inhibit urea utilization for a commercial S. cerevisiae strain were identified. In addition, regulators of nitrogen catabolite repression (NCR) and target of rapamycin (TOR) pathways were identified as being involved in urea accumulation by real‐time quantitative PCR. Based on these results, preferred nitrogen sources were found to repress urea utilization by converting them to glutamine or glutamate. Moreover, the results indicated that the manner of urea metabolism regulation was different for two positive regulators involved in NCR; Gln3p can be retained in the cytoplasm by glutamine, while Gat1p can be retained by glutamine and glutamate. Furthermore, this was confirmed by fluorescence location detection. These new findings provide new targets for eliminating EC and other harmful nitrogen‐containing compounds in fermented foods. Copyright © 2013 John Wiley & Sons, Ltd.
Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors
Authors: Jesson Gérald , Brisander Magnus , Andersson Per , Demirbüker Mustafa , Derand Helene , Lennernäs Hans , Malmsten Martin 
Published: August 2013

ABSTRACT

Purpose
A versatile methodology is demonstrated for improving dissolution kinetics, gastrointestinal (GI) absorption, and bioavailability of protein kinase inhibitors (PKIs).

Methods
The approach is based on nanoparticle precipitation by sub- or supercritical CO2 together with a matrix-forming polymer, incorporating surfactants either during or after nanoparticle formation. Notably, striking synergistic effects between hybrid PKI/polymer nanoparticles and surfactant added after particle formation is investigated.

Results
The hybrid nanoparticles, consisting of amorphous PKI embedded in a polymer matrix (also after 12 months), display dramatically increased release rate of nilotinib in both simulated gastric fluid and simulated intestinal fluid, particularly when surfactants are present on the hybrid nanoparticle surface. Similar results indicated flexibility of the approach regarding polymer identity, drug load, and choice of surfactant. The translation of the increased dissolution rate found in vitro into improved GI absorption and bioavalilability in vivo was demonstrated for male beagle dogs, where a 730% increase in the AUC0–24h was observed compared to the benchmark formulation. Finally, the generality of the formulation approach taken was demonstrated for a range of PKIs.

Conclusions
Hybrid nanoparticles combined with surfactant represent a promising approach for improving PKI dissolution rate, providing increased GI absorption and bioavailability following oral administration.
Prevalence of developmental dysplasia of the hip in children with clubfoot
Authors: Chou Daud TS , Ramachandran Manoj 
Published: August 2013

Purpose The relationship between congenital talipes equinovarus (CTEV) and developmental dysplasia of the hip (DDH) remains uncertain. The role of routine hip screening in children with CTEV is debated. A recent study has found a high incidence of DDH in patients with CTEV. The aim of our study was to determine the true prevalence of radiographic hip dysplasia and identify the need for routine hip screening in patients treated for CTEV. Methods From a single centre database of 165 children consisting of 260 CTEV, a prospective radiological prevalence study of 101 children was performed over a period of 3 months. A single anterior-posterior pelvic radiograph was performed at a minimum age of 5 months. The DDH was determined by a single senior investigator based on the age-adjusted acetabular index (AI) as described by Tonnis. Results There were no dislocations or subluxations. According to the age-adjusted AI, 16 children had ‘light’ dysplasia and one child had ‘severe’ dysplasia. The child with severe dysplasia was known to have DDH and had already undergone treatment. The 16 children with light dysplasia did not require any form of treatment. Conclusion Out of one hundred and one children with CTEV, only one had DDH requiring treatment. This is consistent with the majority of the literature supporting the premise that there is no true association between CTEV and DDH. We, therefore, feel that routine hip screening for children with CTEV is not supported by current evidence and cannot be recommended.
Achieving Near-Zero and Zero: Who Said Interventions and Controls Don't Matter?
Authors: Matocha Donna 
Published: August 2013

AbstractBackground: Implementation of the Institute for Healthcare Improvement's Central Line Bundle in 2005 did not result in attainment of 0 central line-associated bloodstream infections (CLABSIs).Purpose: To establish process improvements to eliminate CLABSIs.Methods: Infection Prevention and Intravenous Therapy Departments at our institution formed a collaborative partnership in 2008 to eliminate CLABSIs. Staff education, daily surveillance, and implementing evidence-based practice into policies, protocols, and product selection were utilized. A study designed to capture and track multiple interventions from the beginning versus time was implemented.Results: There were a total of 7 CLABSIs over 5 years, which trended down by year from 3 to 2 to 1 to 1 to 0. The average annual CLABSI rate of infections per 1,000 catheter line days declined from 1.068 to 0.849 to 0.508 to 0.449 to 0.000. The full 3-year simple average from 2009 to 2011, after all of the key interventions were phased-in, was 0.3048.Conclusions: Collaboration and commitment played a role in implementing changes. Empowering staff through education that increases knowledge, understanding, and skills improves patient safety and patient outcomes. Process changes and practice protocols supported by evidence-based practice along with efficacious products played a crucial part in getting to 0 CLABSIs. Layered kits with products placed in the correct order of use can increase aseptic technique compliance. Prompt identification of individual CLABSI episodes with prompt intervention to the specific individuals involved has been shown to be cost-effective and can be implemented in most hospitals.
Supporting the Sustainability Journey of Tertiary International Students in Australia
Authors: Sidiropoulos Liz , Wex Irene , Sibley Jonathan 
Published: August 2013

AbstractThis article reports the findings of a pilot Education for Sustainability (EfS) program implemented in 2011 for international students in a multi-campus distributed learning environment at an Australian university. It outlines the context of the pilot EfS program and reports survey findings of the environmental attitudes and sustainability worldviews of international students. The pilot EfS program entailed in-class presentations to students in a variety of Business and IT programs at diploma, undergraduate and postgraduate levels. Students were introduced to sustainability concepts and the role of graduate skills in their future professional practice. Students were also encouraged to adopt personal sustainability behaviours and assisted to connect their individual courses/programs to sustainability outcomes. Surveys consisting of open-ended questions and the Revised NEP (New Environmental Paradigm) questionnaire were conducted in a range of settings in order to develop an understanding of the sustainability attitudes and knowledge of international students. These were conducted in participating and non-participating EfS classes and also in classes with and without sustainability topics in the curriculum. The findings report the impact of these sustainability interventions on students’ environmental views and attitudes. Finally, these findings are contextualised in suggested routes for scaffolding the learning journey of international students towards sustainability.
Conditional statistics of the turbulent/non-turbulent interface in a jet flow
Authors: Gampert Markus , Narayanaswamy Venkat , Schaefer Philip , Peters Norbert 
Published: August 2013

AbstractUsing two-dimensional high-speed measurements of the mixture fraction $Z$ in a turbulent round jet with nozzle-based Reynolds numbers $R{e}_{0} $ between 3000 and 18 440, we investigate the scalar turbulent/non-turbulent (T/NT) interface of the flow. The mixture fraction steeply changes from $Z= 0$ to a final value which is typically larger than 0.1. Since combustion occurs in the vicinity of the stoichiometric mixture fraction, which is around $Z= 0. 06$ for typical fuel/air mixtures, it is expected to take place largely within the turbulent/non-turbulent interface. Therefore, deep understanding of this part of the flow is essential for an accurate modelling of turbulent non-premixed combustion. To this end, we use a composite model developed by Effelsberg & Peters (Combust. Flame, vol. 50, 1983, pp. 351–360) for the probability density function (p.d.f.) $P(Z)$ which takes into account the different contributions from the fully turbulent as well as the turbulent/non-turbulent interface part of the flow. A very good agreement between the measurements and the model is observed over a wide range of axial and radial locations as well as at varying intermittency factor $\gamma $ and shear. Furthermore, we observe a constant mean mixture fraction value in the fully turbulent region. The p.d.f. of this region is thus of non-marching character, which is attributed physically to the meandering nature of the fully turbulent core of the jet flow. Finally, the location and in particular the scaling of the thickness $\delta $ of the scalar turbulent/non-turbulent interface are investigated. We provide the first experimental results for the thickness of the interface over the above-mentioned Reynolds number range and observe $\delta / L\sim R{ e}_{\lambda }^{- 1} $, where $L$ is an integral length scale and $R{e}_{\lambda } $ the local Reynolds number based on the Taylor scale $\lambda $, meaning that $\delta \sim \lambda $. This result also supports the assumption often made in modelling of the stoichiometric scalar dissipation rate ${\chi }_{st} $ being a Reynolds-number-independent quantity.
Interpersonal exchange and freedom for resource acquisition
Authors: Adamopoulos John 
Published: August 2013

AbstractThe relationship of climate and monetary resources to various freedoms can be enriched if the conceptual links – “psychobehavioral adaptations” – are conceptualized more broadly as reflections of a richer cultural context that involves multiple physical and psychological resources, as proposed by social resource theory and a number of models of the emergence of social meaning.
Press freedom, oil exports, and risk for natural disasters: A challenge for climato-economic theory?
Authors: Arantes Joana , Grace Randolph C. , Kemp Simon 
Published: August 2013

AbstractDoes the interaction between climactic demands, monetary resources, and freedom suggest a more general relationship between the environmental challenges that human societies face and their resources to meet those challenges? Using data on press freedom (Van de Vliert 2011a), we found no evidence of a similar interaction with natural resources (as measured by oil exports) or risk for natural disasters.
Individual identity and freedom of choice in the context of environmental and economic conditions
Authors: Baumeister Roy F. , Park Jina , Ainsworth Sarah E. 
Published: August 2013

AbstractVan de Vliert's findings fit nicely with our recent arguments implying that (1) differentiated selfhood is partly motivated by requirements of cultural groups, and (2) free will mainly exists within culture. Some cultural groups promote individual freedom, whereas others constrict it so as to maintain elites' power and privilege. Thus, freedom is, to a great extent, a creation of culture.
Improving climato-economic theorizing at the individual level
Authors: Fischer Ronald 
Published: August 2013

AbstractUsing representative data from 55 nations, I show that individual level wealth interacts with climate in predicting individual happiness but not postmaterialism values. I propose that more research is needed to identify (a) the specific mechanisms of how wealth buffers climatic demands at the individual level and (b) the neurocognitive and physiological reactions of individuals situated in different ecological niches.
Shared adaptiveness is not group adaptation
Authors: Paternotte Cédric 
Published: August 2013

AbstractClimate stresses and monetary resources seem to lead to different collective adaptations. However, the reference to adaptation and to ambiguous collective dimensions appears premature; populations may entertain nothing more than shared adaptiveness. At this point, the intricacy of the underlying evolutionary processes (cultural selection, fitness-utility decoupling) very much obscures any diagnosis based on correlations.
Linkage between bacterial and fungal rhizosphere communities in hydrocarbon-contaminated soils is related to plant phylogeny
Authors: Bell Terrence H , El-Din Hassan Saad , Lauron-Moreau Aurélien , Al-Otaibi Fahad , Hijri Mohamed , Yergeau Etienne , St-Arnaud Marc 
Published: August 2013

Abstract
Phytoremediation is an attractive alternative to excavating and chemically treating contaminated soils. Certain plants can directly bioremediate by sequestering and/or transforming pollutants, but plants may also enhance bioremediation by promoting contaminant-degrading microorganisms in soils. In this study, we used high-throughput sequencing of bacterial 16S rRNA genes and the fungal internal transcribed spacer (ITS) region to compare the community composition of 66 soil samples from the rhizosphere of planted willows (Salix spp.) and six unplanted control samples at the site of a former petrochemical plant. The Bray–Curtis distance between bacterial communities across willow cultivars was significantly correlated with the distance between fungal communities in uncontaminated and moderately contaminated soils but not in highly contaminated (HC) soils (&gt;2000 mg kg−1 hydrocarbons). The mean dissimilarity between fungal, but not bacterial, communities from the rhizosphere of different cultivars increased substantially in the HC blocks. This divergence was partly related to high fungal sensitivity to hydrocarbon contaminants, as demonstrated by reduced Shannon diversity, but also to a stronger influence of willows on fungal communities. Abundance of the fungal class Pezizomycetes in HC soils was directly related to willow phylogeny, with Pezizomycetes dominating the rhizosphere of a monophyletic cluster of cultivars, while remaining in low relative abundance in other soils. This has implications for plant selection in phytoremediation, as fungal associations may affect the health of introduced plants and the success of co-inoculated microbial strains. An integrated understanding of the relationships between fungi, bacteria and plants will enable the design of treatments that specifically promote effective bioremediating communities.