bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and long-term survival of proximal gastrectomy after neoadjuvant therapy for locally advanced proximal gastric cancer: A propensity-score-matched analysis
Authors: Gu Tingfei , Wang Yinkui , Wu Zhouqiao , He Ning , Li Yingai , Shan Fei , Li Ziyu , Ji Jiafu 
Published: August 2024

Abstract

Background:
Neoadjuvant therapy enhances the possibility of achieving radical resection and improves the prognosis for locally advanced gastric cancer (GC). However, there is a lack of evidence regarding the optimal extent of resection for locally advanced proximal GC after neoadjuvant therapy.

Methods:
In this study, 330 patients underwent resection in Peking University Cancer Hospital, with curative intent after neoadjuvant therapy for histologically confirmed proximal GC from January 2009 to December 2022. Among them, 45 patients underwent proximal gastrectomy (PG), while 285 underwent total gastrectomy (TG).

Results:
In this study, 45 patients underwent proximal gastrectomy (PG), while 285 underwent total gastrectomy (TG). After propensity-score matching, 110 patients (71 TG and 39 PG) were included in the analysis. No significant differences between PG and TG regarding short-term outcomes and long-term prognosis were found. Specifically, PG demonstrated comparable overall survival to TG (P = 0.47). Subgroup analysis revealed that although not statistically significant, PG showed a potential advantage over TG in overall survival for patients with tumor-long diameters less than 4 cm (P = 0.31). However, for those with a long diameter larger than 4 cm, TG had a better survival probability (P = 0.81). No substantial differences were observed in baseline characteristics, surgical safety, postoperative recovery, and postoperative complications.

Conclusion:
For locally advanced proximal GC with objective response to neoadjuvant therapy (long diameter <4 cm), PG is an alternative surgical procedure. Further research and prospective studies are warranted to validate these findings and guide clinical decision-making.
Malignant hypertension in a patient with Turner syndrome: A case report
Authors: Yang Ying , Ye Yong , Wang Huibo , Wu Hui , Zhang Jing , Lv Zhiyang , Li Wen , Yang Jian 
Published: August 2024

Rationale:Turner syndrome is characterized by complete or partial loss of the second sex chromosome. In patients with Turner syndrome, hypertension is well described. However, the literature regarding malignant hypertension is scarce. Therefore, an accurate and timely diagnosis and treatment are important.Patient concerns:A 13-year-old female with Turner syndrome presented to the emergency department with malignant hypertension, headache, spraying vomiting, convulsion, and loss of consciousness. Considering her medical history, symptoms, and auxiliary examination, secondary hypertension (primary reninism) was suspected, but without any occupying or hyperplasia in renal and adrenal.Diagnosis:A type of secondary hypertension, primary reninism.Interventions:The patient was immediately transferred to the pediatric intensive care unit. Subsequently, she was given nifedipine 0.35 mg/kg and captopril 0.35mg/kg to reduce blood pressure (BP), mannitol and furosemide to reduce cranial pressure, and phenobarbital and midazolam to terminate restlessness successively. Three hours later, the BP was consistently higher than 170/120 mm Hg, sodium nitroprusside was pumped intravenously, then, giving oral drug transition. Finally, she was given Valsartan-Amlodipine Tablets (I) (80 mg valsartan and 5 mg amlodipine per day) and bisoprolol (2.5 mg per day).Outcomes:For 2.5 years of follow-up, the BP reduced to 110–130/60–85 mm Hg, heart rate ranged between 65 and 80 bpm, and she could go to school without any headache, convulsion, and syncope.Lessons:The clinical phenotype of Turner syndrome is complex and varied, affecting multiple systems and organs. Turner syndrome with malignant hypertension is rare, so we should systematically evaluate secondary hypertension, target-organ damage, and accompanied by standard management when Turner syndrome presents with hypertension.
Optical molecular imaging in cancer research: current impact and future prospect
Authors: Li Yinuo , Li Zihan , Li Yuting , Gao Xiaofan , Wang Tian , Ma Xiangyi , Wu Mingfu 
Published: August 2024

Abstract
Cancer has long been a major threat to human health. Recent advancements in molecular imaging have revolutionized cancer research by enabling early and precise disease localization, essential for effective management. In particular, optical molecular imaging is an invaluable cancer detection tool in preoperative planning, intraoperative guidance, and postoperative monitoring owing to its noninvasive nature, rapid turnover, safety, and ease of use. The tumor microenvironment and cells within it express distinct biomarkers. Optical imaging technology leverages these markers to differentiate tumor tissues from surrounding tissues and capture real-time images with high resolution. Nevertheless, a robust understanding of these cancer-related molecules and their dynamic changes is crucial for effectively managing cancer. Recent advancements in optical molecular imaging technologies offer novel approaches for cancer investigation in research and practice. This review investigates the modern optical molecular imaging techniques employed in both preclinical and clinical research, including bioluminescence, fluorescence, chemiluminescence, photoacoustic imaging, and Raman spectroscopy. We explore the current paradigm of optical molecular imaging modalities, their current status in preclinical cancer research and clinical applications, and future perspectives in the fields of cancer research and treatment.
Cadherin-26 drives macrophage alternative activation via suppressing STUB1-mediated IL-4Rα ubiquitination in asthma
Authors: Chen Gongqi , Chen Shengchong , Huang Chunli , Gu Wei , Jie Huiru , Zhao Lu , Kong Weiqiang , Gao Jiali , Feng Yuchen , Yi Lingling , Gao Peisong , Zhen Guohua 
Published: August 2024

IntroductionIL-4 receptor (IL-4R)-mediated alternative activation of macrophage drives type 2 airway inflammation. Cadherin-26 (CDH26) upregulates epithelial type II IL-4R signaling in asthma. However, whether CDH26 contributes to type I IL-4R-mediated macrophage activation and the mechanism by which CDH26 upregulates IL-4R expression remains unknown.MethodsCDH26 expression in bronchoalveolar lavage cells of asthma patients was examined using quantitative PCR and immunostaining. Airway inflammation and macrophage activation were assessed in ovalbumin-sensitized and challengedCdh26fl/flLyz2Creand control mice. Mechanistic experiments included IL-4Rα degradation and ubiquitination assay, CDH26 co-immunoprecipitation and mass spectrometry analysis.Cdh26siRNA encapsulated lipid nanoparticles were used to treat the mouse model.ResultsCDH26 expression was enhanced in bronchoalveolar lavage cells from patients with eosinophilic asthma and was localized to macrophages. Airway eosinophilia, mucous cell metaplasia and macrophage alternative activation were significantly suppressed in ovalbumin-challengedCdh26fl/flLyz2Cremice compared to control mice.Cdh26deficiency inhibited the expression of M2 markers as well as IL-4Rα expression in mouse bronchoalveolar lavage macrophages, cultured bone marrow-derived macrophages, and primary lung macrophages. Furthermore, CDH26 knockdown enhanced whereas CDH26 overexpression suppressed IL-4Rα ubiquitination and proteasomal degradation in vitro. Mechanistically, CDH26 directly interacts with STUB1 and suppresses the binding of STUB1 to IL-4Rα and subsequent ubiquitination-proteasomal degradation.Cdh26siRNA encapsulated lipid nanoparticles markedly alleviated airway eosinophilia, mucus metaplasia and macrophage alternative activation in the mouse model.ConclusionsCDH26 interacts with STUB1 and suppresses STUB1-mediated IL-4Rα ubiquitination-proteasomal degradation, thereby amplifying IL-4R signaling in macrophages in asthma. CDH26 is a potential therapeutic target for asthma.Take-Home MessageMacrophage CDH26 is upregulated in asthma patients, andCdh26deficiency suppresses macrophage alternative activation. CDH26 directly interacts with STUB1 and inhibits STUB1-mediated IL-4Rα ubiquitination and degradation, thus amplifying IL-4R signaling.
ARPE-19 Epithelial Cells Fail To Initiate Type-I Interferon Signaling in Response to Human Cytomegalovirus Infection
Authors: Andrade-Medina Mariana , Greco Todd M. , Cristea Ileana M. , Oberstein Adam 
Published: August 2024

AbstractARPE-19 cells are a commonly used epithelial model for studying human cytomegalovirus (HCMV) infection. We recently found that ARPE-19 cells assume a mesenchymal phenotype when maintained at low confluency and that ARPE-19 cells resemble mesenchymal fibroblasts rather than epithelial cells in HCMV infection assays. Here, using comparative proteomics analysis, we find that subconfluent ARPE-19 cells are also deficient in their ability to initiate canonical type-I interferon signaling. Comparative proteomic analysis between subconfluent ARPE-19 and MRC-5 cells revealed a lack of canonical type-I interferon response in ARPE-19 cells upon HCMV infection, evidenced by the absence of interferon stimulated gene (ISG) induction. qRT-PCR and RNA-sequencing analysis revealed that ARPE-19 cells fail to initiateinterferon-betatranscription in response to HCMV infection, yet they are competent to respond to exogenously interferon-b, indicating a failure in early pathogen detection. ARPE-19 cells showed low baseline levels of key intracellular pattern recognition receptors (PRRs) such as CGAS and IFI16, as well as the signaling molecule STING. This deficiency was associated with a failure to activate IRF3 phosphorylation, a crucial step in interferon signaling. These findings suggest an upstream defect in the early detection of viral components, likely due to reduced expression of critical PRRs. ARPE-19 cells may be inherently deficient in initiating interferon responses due to their derivation or possibly due to their origin from an immune-privileged tissue. Our results continue to highlight important phenotypic characteristics of the ARPE-19 cell line; important considerations for those using ARPE-19 cells as an experimental infection model for studying HCMV or other human viruses.
Making a big splash: packaging imagery with implied motion enhances product liking through design appeal and naturalness perception
Authors: Lidón López Iván , Gil-Pérez Ignacio , Rebollar Rubén , Díez-Calvo Susana , Heras-Romanos Elena 
Published: August 2024

PurposeThis paper aims to investigate how implying movement in food packaging imagery may affect product liking. Furthermore, the underlying mechanism is investigated by studying the effect of implied motion visuals on design appeal and naturalness perception.Design/methodology/approachTwo packages of pineapple juice were designed in which the implied motion depicted in their imagery was manipulated, and a tasting experiment was conducted in which two samples of the same juice were evaluated.FindingsThe results show that the effect of packaging imagery on product liking occurs indirectly through both design appeal and the product naturalness perception. The results of a parallel multiple-mediator analysis show that (1) depicting implied motion made the package be perceived as more appealing, (2) the product corresponding to the package depicting implied motion was perceived as being more natural, and (3) both effects equally contributed to the positive effect of visuals depicting implied motion on product liking.Originality/valueOverall, these findings widen our understanding of the effects of packaging design on product liking and may help both designers and manufacturers design more appropriate packaging for their products.
Supply risk management and timely completion of force account construction projects among local government authorities in Dodoma, Tanzania
Authors: Mwaiseje Shadrack Samwel , Mchopa Alban Dismas , Panga Faustine Peter 
Published: August 2024

PurposeThe study’s purpose is to contribute to the supply risk management literature by examining its implications in Tanzania, specifically in the timely completion of force account construction projects in Local Government Authorities (LGAs).Design/methodology/approachA cross-sectional survey design was employed to gather data from 318 respondents in primary schools within the Dodoma region. A covariance-based structural equation modelling (CB-SEM) structural equation modelling was employed to examine the relationship of the variables.FindingsThe study’s findings underscore the crucial role of supply risk management, including multi-sourcing, effective supplier selection, post-qualification of suppliers, and effective communication with suppliers in the timely completion of FA construction projects. Notably, effective supplier selection emerges as the most influential factor, significantly contributing to the timely completion of these projects.Research limitations/implicationsThe study focused on LGAs in Tanzania. It is important to exercise caution when making broad generalizations about the findings. Also, the study was based on a cross sectional survey design; future research could consider a longitudinal design approach.Practical implicationsThis study offers practical insights for procurement practitioners and members of the Force Account committee in the public sector, offering guidance on how to improve the management of supply risks and, consequently, enhance the timely completion of construction projects.Originality/valueThis study stands out in the literature by examining the implications of supply risk management on the timely completion of force account construction projects in Tanzania. It significantly enriches the existing knowledge of supply risk management, particularly in the context of effective supplier selection in public procurement. These insights are of great value to researchers, practitioners, and policymakers in the field.
Fire hazard management in dining properties: a case study
Authors: Hassanain Mohammad A. , Sawalha Haitham , Hamida Mohammad B. , Alshibani Adel , Zami Mohammad Sharif 
Published: August 2024

PurposeThis paper explores the relevant fire code requirements and outlines the development of an evaluation tool based on these codes to evaluate fire safety measures in dining properties.Design/methodology/approachExisting literature was examined to identify the combustible materials, fire causes and factors making these properties prone to fire incidents. An evaluation method, based on code regulations, for ensuring fire safety in dining properties was then developed and tested on a specific dining facility to validate its practicality.FindingsForty requirements, grouped into seven categories, were identified for ensuring fire safety in dining properties. The case study exposed multiple violations of fire safety, leading to corrective measures for enhancing the fire safety status of the building.Practical implicationsThis study introduced a methodical approach for raising awareness, among property managers of dining properties, about fire incidences and their consequences. It presents an evaluation tool for assessing the compliance level with fire codes and standards.Originality/valueDining properties are facilities that offer both dine-in and take-out food services. Given the increasing number of fire incidents in dining properties worldwide, there is a substantial demand for a process to audit the adherence to fire safety codes in these properties. This study presents a systematic approach to increase public knowledge of fire events and their effects in dining properties.
Social inclusion practices in the upstream supply chain: a systematic literature review
Authors: Castre-de Chabot Svetlana , Ruel Salomée , Jaegler Anicia , Gold Stefan 
Published: August 2024

PurposeThis study conducts a systematic literature review (SLR) on social inclusion within upstream supply chains, targeting a notable literature gap in modern SCM discourse. By delving into this critical, yet underexamined, domain, this study spotlights the pressing need to incorporate social inclusion practices, particularly as global supply chains face increased scrutiny over their social ramifications. It examines social inclusion’s intricacies, offering practical insights for industry professionals to adopt, so that trustworthy social inclusion practices can proliferate across their upstream supply chains, thereby making a substantial contribution to both theoretical understanding and practical application.Design/methodology/approachEmploying five search queries across two leading academic databases, this investigation reviewed 86 articles that examined social issues related to social inclusion in the upstream supply chain. Via content analysis, this study aims to answer essential research questions and employs statistical bibliometric analyses to investigate the collected data further.FindingsThis study’s findings establish a definition of social inclusion within the upstream supply chain and present a conceptual framework delineating levers and indicators for evaluating such practices. Through rigorous analysis, it becomes apparent that mechanisms such as supplier compliance, collaboration and development are crucial for promoting social inclusion; however, their importance differs at various levels of suppliers in multi-tiered supply chains. Furthermore, a methodological matrix is introduced for assessing social inclusion practices’ efficacy, equipping practitioners with a roadmap for developing and executing strategies that extend social inclusion efforts throughout the supply chain, as well as emphasising these levers through monitoring, assessment and application of six specified indicators.Originality/valueThis study contributes to the dialogue surrounding upstream supply chain management by spotlighting social inclusion practices, addressing the literature gap in comprehending how social inclusion dynamics operate within upstream supply chains and outlining a distinct direction for forthcoming research. By highlighting the pressing importance of enhancing social inclusion practices, this study not only enriches the theoretical landscape but also lays the groundwork for subsequent empirical studies aimed at deciphering the complexities and practical hurdles associated with the efficient execution of these practices.
The effect of leadership self-efficacy on the decision to be a school principal: the mediating roles of motivation-to-lead and worries-about-leadership
Authors: Arastaman Gökhan , Fidan Tuncer , Ayyıldız Pınar , Kurt Türker 
Published: August 2024

PurposeThis study aimed to examine the relationship between leadership self-efficacy and the decision to be a school principal and the mediating effects of motivation-to-lead and worries-about-leadership in this relationship.Design/methodology/approachA total of 375 teachers working in public high schools in Ankara, Türkiye participated in this cross-sectional predictive study. Descriptive statistics, structural equation modeling and bootstrapping were used in the analysis of the data.FindingsLeadership self-efficacy was found to increase both motivation-to-lead and worries-about-leadership. Motivation-to-lead positively influenced the decision to be a school principal, whereas worries-about-leadership did so negatively. Furthermore, leadership self-efficacy had an indirect positive effect on the decision to be a school principal through motivation-to-lead and worries-about-leadership.Practical implicationsBased on the findings, it is recommended to offer teachers training programs on school administration and leadership. Furthermore, we suggested providing teachers with administrative internship and mentorship opportunities to help them gain field experience and benefit from the experiences of incumbent school principals in school leadership.Originality/valueThis study confirmed that theoretical assumptions about self-efficacy are also relevant in the decision-making process regarding the school principalship: leadership self-efficacy can be the source of both motivation and worry. This study also implied that teachers make their choices about the school principalship by considering the potential advantages and disadvantages of the position.
The impact of remote auditing on audit quality: the moderating role of technology readiness
Authors: Alma’aitah Ruba Taleb , Al-Hajaya Krayyem , Sawan Nedal , Alzeban Abdulaziz 
Published: August 2024

Purpose
This study aims to investigate the impact of remote auditing on audit quality and explore the moderating role of both the client’s and the audit firm’s technology readiness in this interaction.

Design/methodology/approach
Data was collected through a questionnaire survey distributed to 360 audit professionals in Jordan, resulting in 208 valid responses. The data was analysed using SmartPLS – structural equation modelling.

Findings
The results showed that remote auditing significantly and positively affect audit quality. This study found that the technology readiness of both the audit firm and the client greatly influences audit quality. Notably, the technology readiness of the client positively enhances the relationship between remote auditing and audit quality, while the technology readiness of the audit firm does not play such a role.

Practical implications
The findings are of value to policymakers in terms of the positive impact of remote auditing on audit quality, and the role of technology readiness in this regard. In particular, they allow policymakers and regulators of audit profession to make informed and relevant decisions pertaining to the adoption of remote auditing. The findings also indicate the significance for audit firms and business institutions to pay special attention to developing their technology capabilities to keep abreast of rapid technology advancements, ensuring the maximum benefits for auditing profession, thereby enhancing their efficiency and effectiveness.

Originality/value
The importance of this study lies in its unique contribution to bridging the research gap related to understanding the pivotal role of technology readiness in enhancing the relationship between the use of remote auditing and the achievement of high audit quality.