bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic liability to human serum metabolites is causally linked to telomere length: insights from genome-wide Mendelian randomization and metabolic pathways analysis
Authors: Liu Jingwen , Pan Renbing 
Published: August 2024

BackgroundTelomere has been recognized as a biomarker of accelerating aging, and telomere length (TL) shortening is closely related to diverse chronic illnesses. Human serum metabolites have demonstrated close correlations with TL maintenance or shortening in observational studies. Nevertheless, little is known about the underlying pathological mechanisms, and Mendelian randomization (MR) analysis of serum metabolites may provide a more comprehensive understanding of the potential biological process.MethodsWe employed a two-sample MR analysis method to assess the causal links between 486 serum metabolites and TL. We applied the inverse-variance weighted (IVW) approach as our primary analysis, and to assure the stability and robustness of our results, additional analysis methods including the weighted median, MR-Egger, and weighted mode were conducted. MR-Egger intercept test was utilized to detect the pleiotropy. Cochran’s Q test was implemented to quantify the extent of heterogeneity. Furthermore, the pathway analysis was conducted to identify potential metabolic pathways.ResultsWe identified 11 known blood metabolites associated with TL. Among these metabolites, four were lipid (taurocholate, dodecanedioate, 5,8-tetradecadienoate, and 15-methylpalmitate), one amino acid (levulinate (4-oxovaleate)), one carbohydrate (lactate), one nucleotide (pseudouridine), one energy (phosphate), and three xenobiotics (2-hydroxyacetaminophen sulfate, paraxanthine, and ergothioneine). The known protective metabolites included levulinate (4-oxovaleate), dodecanedioate, 5,8-tetradecadienoate, lactate, phosphate, paraxanthine, and ergothioneine. Multiple metabolic pathways have been identified as being implicated in the maintenance of telomere length.ConclusionOur MR analysis provided suggestive evidence supporting the causal relationships between 11 identified blood metabolites and TL, necessitating further exploration to clarify the mechanisms by which these serum metabolites and metabolic pathways may affect the progression of telomeres.
Bibliometric analysis of global research in palliative care for cervical cancer
Authors: Almobarak Fhaied 
Published: August 2024

ObjectiveThe present study aims to conduct a comprehensive bibliometric analysis of global research in palliative care for cervical cancer, providing insights into publication trends, authorship patterns, influential journals, and thematic concentrations.MethodsA bibliometric analysis approach was employed using metadata extracted from Scopus spanning 2000-2023. The search utilized main terms related to cervical cancer and palliative care. Data analysis and visualization were performed using the Bibliometrix R Package’s web app Biblioshiny and VOSviewer software.ResultsThe study identified 2,492 publications on palliative care for cervical cancer, with a notable peak in 2021. The analysis revealed a diverse publication landscape, encompassing primarily articles. Citation analysis showed a staggering 63,994 citations. The most relevant journals were The Lancet Oncology, Gynecologic Oncology, and International Journal of Gynecological Cancer. The study also highlighted influential authors, institutions, and countries, with Harvard University, the University of Toronto, and the University of Texas MD Anderson Cancer Center leading in publications.DiscussionThe findings reflected a growing interest in palliative care for cervical cancer, marked by increasing publications over the years. However, the analysis indicated limited international collaborations, with research efforts concentrated in high-income countries. Thematic areas include surgery, palliative care, chemotherapy, radiotherapy, and quality of life. Thus, further collaborations and research in developing countries are needed.ConclusionThis bibliometric analysis showcased a comprehensive overview of the global research landscape on palliative care for cervical cancer. The study identified trends, key contributors, and thematic concentrations, offering valuable insights for future research directions and enhancing palliative care services. Addressing the identified gaps, fostering international collaborations, and directing research efforts toward developing countries can contribute to the advancement of palliative care for cervical cancer globally.
Changes of masseter muscle after mandible distraction osteogenesis in patients with Hemifacial microsomia: a retrospective study
Authors: Han Wenqing , Kim Byeong Seop , Zhang Ziwei , Chen Xiaojun , Yan Yingjie , Lin Li , Zhang Yan , Chai Gang 
Published: August 2024

IntroductionMandible distraction osteogenesis (MDO) is widely used to reconstruct the mandible in patients with mild Hemifacial microsomia (HFM). However, the masseter's response to mandible distraction remains unclear.MethodsIn this study, we analyze the effect of the surgical intervention on masseter muscle by a retrospective analysis. The procedure consisted of a five-day latent period, a three-week distraction period, and a six-month consolidation period. CT data were manually segmented and measured with Mimics software before surgery, within 3 months, and more than 1 year postoperatively. Masseter volume, masseter length, masseter width, and mandible ramus height were measured and analyzed using paired t-test, Pearson, and Spearman correlation analysis.ResultsWe included 21 patients with HFM who underwent mandible distraction osteogenesis from 2015 to 2020. The masseter volume on the affected side increased immediately after surgery from (6,505.33 ± 3,671.95) mm3 to (10,194.60 ± 5638.79) mm3, but decreased to (8,148.38 ± 3,472.57) mm3 at the second follow-up correlated to mandible ramus height (r = 0.395, P = 0.038). A similar trend was observed in changes in masseter length. Symmetry and width of masseter muscle had no longitudinal statistical significance.DiscussionMasseter muscle involvement benefits from MDO in the short term. To achieve long-term efficacy, more attention should be paid to muscle reconstruction.
Mechanism of emergency phytoremediation technology based on a 3D-QSAR pharmacological model
Authors: Li Minghao , Wang Siming , Sun Shimei 
Published: August 2024

IntroductionThe ability of transgenic plants to respond to sudden environmental pollution accidents has become viable. Nonetheless, there is a dearth of research regarding the mechanism by which transgenic plants degrade organic pollutants. Hence, this study aimed to elucidate the process of organic pollutant degradation by plants, offering theoretical support for the application of transgenic plant emergency phytoremediation technology.MethodsIn this investigation, we developed a 3D-QSAR pharmacophore model to represent the collective impact of plant resistance and phytodegradation. This was achieved by employing integrated effect values following treatment with a sine function approach. Moreover, we have undertaken an inaugural exploration of the coregulatory mechanism involved in plant resistance and pollutant degradation within plants. Additionally, we applied virtual molecular modification techniques for analysis and validation, striving for a more indepth understanding of the molecular-level enhancement mechanism related to the degradation of pollutants within plant organisms. Results and discussionThe mechanism analysis results of the Hypo 1 pharmacophore model were verified, indicating that hydrophobic characteristics affect the resistance and degradation of PCBs in plants, significantly affecting the degradation effect of pollutants in plants.
The impact of public art education on college students’ mental health literacy
Authors: Zhang Shengyu , Zhao Lege 
Published: August 2024

IntroductionThis study aims to explore the impact of public art education on the mental health literacy of College Students.MethodsConducted over a four-month period, the intervention involved freshmen from a Chinese college, comparing 1,334 students in the experimental group with 1,139 in the control group. Data were collected through a self-developed questionnaire and a standardized mental health literacy scale before and after the intervention.ResultsResults showed that the experimental group’s overall mental health literacy score significantly increased from 64.051 pre-intervention to 79.260 post-intervention, while the control group showed no significant changes during the same period. The experimental group demonstrated significant improvements in their ability to identify psychological disorders, belief in receiving professional help, attitudes towards seeking appropriate help, and knowledge in seeking mental health information. Furthermore, the frequency of classroom interaction was positively correlated with improvements in mental health literacy (regression coefficient = 2.261***), highlighting the critical role of active participation in public art education settings.ConclusionThis study underscores the importance and effectiveness of implementing public art education in higher education and provides empirical support for future educational policies and practices.
A stakeholder co-design approach to designing a dental service for adults experiencing homelessness
Authors: Cairns Declan , Rodriguez Andrea 
Published: August 2024

IntroductionThe homeless population faces a “cliff edge of inequality” when trying to access essential dental services. There are several additional barriers to accessing dental care in comparison to the general population and the heterogeneous nature of patients presents a significant challenge when designing dental services to meet their needs. Following the Smile4Life report in 2009, there is limited up-to-date and population-specific evidence available for the optimal model of service delivery.AimThis study aimed to co-design principles for a prospective dental service for adults experiencing homelessness.MethodsA qualitative methodology was used to incorporate experts-by-experience into elements of co-designing a dental service for adults experiencing homelessness. The study combined elements of an experienced-based co-design framework for healthcare innovation with community-based participatory research. Focus groups with people experiencing homelessness and healthcare practitioners were conducted to identify principles for any prospective dental service, as well as several barriers and enablers to establishing a homeless dental service. The findings were transcribed and analysed using thematic analysis on Nvivo software.ResultsFrom the qualitative analysis five key themes emerged: (1) Impact and expectations of oral health while experiencing homelessness, (2) Barriers to accessing dental care; (3) Practitioner's views about homelessness and access to care; (4) Barriers to designing a homeless service and (5) Enablers for co-designing a new model of dental care delivery for the homeless population.Five key principles for a new model of homeless dental service were identified: (i) Services designed to address the needs of patients; (ii) Services delivered in a safe and welcoming environment (iii) Training and consistency of staff; (iv) Focus on dental education (v) Developing peer mentoring and peer support.ConclusionWhile the barriers to accessing dental care while homeless are well established and understood by healthcare practitioners, more work is required to gain consensus on the most effective way to deliver an innovative a sustainable dental service for patients experiencing homelessness. Previous negative experiences, lack of readily available information on services and barriers to access in the current system could be addressed by developing peer mentors within the homeless community, empowering individuals to share their knowledge and skills to support others in improving their oral health.
The effect of a 5-week therapeutic massage on erector spinae and upper trapezius muscle stiffness as determined by shear-wave elastography: a randomized controlled trial
Authors: Jelen Amadej , Javornik Erina , Meh Sara Gloria , Kozinc Žiga 
Published: August 2024

IntroductionMassage is an effective treatment for reducing pain, swelling, stiffness, and improving muscle mobility. Although self-reported benefits on muscle stiffness and pain are well-known, studies measuring muscle stiffness objectively are scarce.MethodsA randomized controlled trial involving 30 recreationally active young women (22.3 ± 0.4 years) was conducted. The participants were randomly assigned to either the control group or the intervention group which received a series of five 30-min whole back therapeutic massage sessions over 5 weeks. Shear wave elastography was used to assess muscle stiffness (erector spinae (ESp) and upper trapezius (UT) muscles) before and after the intervention and at 3-week follow-up.ResultsFor ESp, there was no statistically significant time × group interaction (F = 2.908; p = 0.063). However, there was a statistically significant and large time × group interaction for UT (F = 13.533; p = 0.006; η2 = 0.19). Post-hoc testing for time indicated that the shear modulus in the intervention group was reduced at follow-up (p = 0.005; d = 1.02), while the difference between baseline and post-intervention measurements were not statistically significant (p = 0.053; d = 0.75).ConclusionIn conclusion, massage significantly reduced proximal UT stiffness both 3 days and 3 weeks after the intervention. However, it had no significant effect on the distal part of UT or the ESp muscle.
PENINGKATAN PENGETAHUAN DAN PERILAKU SARAPAN PADA ANAK SEKOLAH DASAR DENGAN MEDIA VIDEO STOP MOTION
Authors: Dinda Winalda , Gumilar Mulus , Mahmudah Umi , Suprihartono Agung 
Published: August 2024

Sarapan merupakan suatu hal yang penting, tetapi sering diabaikan akibat dari adanya pengetahuan yang tidak memadai dan sikap yang tidak baik tentang pentingnya sarapan. Data menunjukkan 44,6% anak usia sekolah dasar mengonsumsi sarapan dengan kualitas rendah, yaitu dengan asupan energi kurang dari 15% kebutuhan gizi harian. Perlu diberikan penyuluhan gizi untuk meningkatkan pengetahuan dan perilaku sarapan pagi. Media yang digunakan adalah video stop motion. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penyuluhan gizi dengan video stop motion dan power point terhadap pengetahuan dan perilaku sarapan pagi pada siswa SDN Semplak Barat 2 Bogor. Metode Penelitian ini adalah Quasy Experiment with control group pre-test dan post-test design. Sampel penelitian ini adalah siswa kelas V dengan jumlah sampel yang dibagi menjadi dua yaitu kelompok perlakuan diberikan video stop motion (n=20) dan kelompok kontrol diberikan media Power Point (n=20). Hasil penelitian menunjukkan terdapat pengaruh penyuluhan gizi terhadap pengetahuan dan perilaku sebelum dan sesudah diberikan video stop motion dan Power Point dengan nilai p<0,05 (p=0,000), kemudian tidak terdapat perbedaan rata-rata yang signifkan antara pemberian perlakuan menggunakan video stop motion dengan Power Point dalam penyuluhan gizi terhadap pengetahuan (nilai p=0,876) dan perilaku sarapan pagi (nilai p=0,611) dengan nilai p>0,05. Penyuluhan perlu melibatkan orang tua.
Peningkatan Daya Saing Lulusan SMAN 1 Banyumas dalam Memasuki Jenjang Pendidikan Tinggi melalui Pelatihan Tes Potensi Skolastik
Authors: Setyawan Yudi , Suryowati Kris , Hamzah Amir , Daton Balamakin Virgilius 
Published: August 2024

Abstrak
Kegiatan pengabdian masyarakat ini merupakan salah satu realisasi kerjasama antara Jurusan Statistika IST AKPRIND Yogyakarta dengan SMAN 1 Banyumas Jawa Tengah. Sebagian besar peserta didik Kelas XII di SMAN 1 Banyumas ingin melanjutkan studi di perguruan tinggi negeri melalui Seleksi Masuk Berbasis Prestasi (SMBP) dan Seleksi Masuk Berbasis Test (SNBT). Mengingat kuota SNBP sangat terbatas, siswa harus mengikuti SNBT yang tingkat keketatannya tinggi. Karena itu siswa perlu diberi pembekalan tentang hal-hal terkait dengan pemilihan program studi di perguruan tinggi, kuota yang tersedia, serta jenis tes yang digunakan dalam seleksi masuk. Salah satu materi seleksi yang belum terlalu dikenal oleh siswa adalah tes potensi skolastik. Dalam kegiatan ini siswa diberikan sosialisasi tentang materi tes potensi skolastik, contoh-contoh soal tes, tips and tricks dalam mengerjakan soal, serta kiat-kiat lainnya agar dapat memperoleh hasil yang optimal. Melalui evaluasi nilai pre-test dan post-test dapat diketahui bahwa kegiatan ini berhasil meningkatkan nilai test potensi skolastik secara signifikan.
Kata Kunci: Tes Potensi Skolastik, Seleksi Nasional Berbasis Tes, SMAN 1 Banyumas

Abstract
This community service activity is one of the realizations of the collaboration between the Department of Statistics IST AKPRIND Yogyakarta and SMAN 1 Banyumas, Central Java. Most of the Class XII students at SMAN 1 Banyumas wish to continue their studies at public universities through the Achievement-Based Entrance Selection (SMBP) and Test-Based Entrance Selection (SNBT). Given the very limited SNBP quota, students must take part in the SNBT which has a very high level of stringency. Therefore, it is necessary to provide training on several matters related to the selection of study programs in Higher Educations, the available quotas, and the types of tests used in the admission selection. One of the selection materials that students are still not very familiar with is the scholastic aptitude test. In this activity students are given socialization about scholastic aptitude test material, examples of test questions, tips and tricks in working on questions, as well as other tips in order to obtain optimal results. Through the evaluation of the pre-test and post-test results, it can be seen that this activity succeeded in significantly increasing the value of the scholastic aptitude test.

Key Words: Scholastic Aptitude Test, Test-Based National Selection, SMAN 1 Banyumas
Pemberdayaan Santriwati di Pondok Pesantren Al-Miftah dengan Pelatihan Sabun Cuci Piring sebagai Bekal Berwirausaha
Authors: Purwanti Ani , Khasanah Rahayu 
Published: August 2024

Cairan pencuci piring merupakan cairan kental bening berwarna yang mempunyai fungsi untuk membersihkan peralatan dapur. Produk pencuci piring yang berupa cairan pemakaiannya cenderung meningkat di kalangan santriwati Pondok Pesantren Al-Miftah, Mlangi, Nogotirto, Yogyakarta. Hal ini dapat dikorelasikan dengan kebiasaan pencucian piring dan alat rumah tangga lain yang sudah banyak bergeser dari cara-cara yang konvensional dengan menggunakan abu gosok dan sabun colek menuju cara yang baru yang lebih praktis. Di pasaran sudah banyak terdapat produk sabun cair pencuci piring. Setelah dipelajari, ternyata sabun cair ini mudah pembuatannya dan dapat diroduksi sendiri dengan biaya yang lebih sedikit. Untuk meningkatkan pemberdayaan santriwati di Pondok Pesantren Al-Miftah, pengasuh pondok meminta bantuan kepada dosen dari Jurusan Teknik Kimia dan Jurusan Teknik Industri IST AKPRIND Yogyakarta untuk dapat memberikan sosialisasi, pelatihan pembuatan sabun cair cuci piring, dan mendampingi santriwati di pondok tersebut untuk memproduksi sabun cair cuci piring. Kegiatan ini dimaksud untuk dapat memberdayakan santriwati agar dapat memenuhi sendiri kebutuhan sabun cair cuci piring dan santriwati juga diharapkan dapat mempunyai bekal untuk berwirausaha. Pelaksanaan pemberdayaan dimulai pada tanggal 5 Mei 2023 sampai dengan tanggal 7 Mei 2023 dengan beberapa tahapan kegiatan yaitu sosialisasi, pelatihan pembuatan sabun cair cuci piring, dan mendampingi santriwati di pondok Al-Miftah untuk memproduksi sabun cair cuci piring. Pelaksanaan kegiatan ini dapat berjalan dengan baik dan lancar. Santriwati yang mengikuti acara ini antusias menerima materi yang disampaikan, hal ini terlihat dari proses tanya jawab seputar materi pelatihan dan kesungguhan pada saat praktek membuat sabun.

Kata Kunci: sabun cair, cuci piring, santriwati, wirausaha
Pemberdayaan Masyarakat Dalam Memanfaatkan Sumberdaya Lokal Di Girikerto, Turi, Sleman
Authors: Suyanto  
Published: August 2024

Program pemberdayaan masyarakat dilaksanakan dengan mitra yaitu Pemerintah Kalurahan Girikerto, Kapanewonan Turi, Kabupaten Slema. Kegiataan Pengabdian Masyarakat ini bertujuan untuk memberdayakan Masyarakat Kalurahan Girikerto dengan memanfaatkan sumberdaya potensi lokal yang ada dilingkungannya, melalui program pemberdayaan masyarakat anggota UMKM. Kalurahan Girikerto mempunyai potensi lokal yang sangat banyak baik dalam sektor pertaian, perkebunan, peternakan, perikanan, wisaata, buadaya dan industri kreatif. Dalam pelaksanaan kegiatan Pemberdayaan Masyarakat khususnya anggota UMKM dari berbagai sektor sangat antusian mengikuti kegiatan baik dalam bentuk penyuluhan, sarasehan maupun diskusi yang diselenggarakan. Dalam Kegiatan ini melibatkan Pemerintah Kalurahan, Masyarakat bersama sama dengan pengurus dan anggota UMKM. Pihak Universitas Aisyiyah Yogjakarta melakukan koordinasi, dan narasumber dalam pemberdayaan pengembangan potensi lokal dan narasumber dalam pelatihan. Target luaran Kegiatan ini adalah terbinanya masyarakat yang mampu mendayagunakan sumberdaya potensi lokal menjadi bernilai ekonomi, yang mampu meningkatkan perdapatan masyarakat dan lebih sejahtera. Pelaksanaan Kegiatan dilaksanakan dengan metode penyuluhan, sarasehan, dan Diskusi.
Pendampingan Peserta Kompetisi Sains Nasional Bidang Kimia Bagi Siswa SMA N 1 Prambanan, Sleman
Authors: Sulistyaningsih Eka , Purwanti Ani , Sunarsih Sri 
Published: August 2024

Penguasaan ilmu pengetahuan dan teknologi dengan nilai integritas tinggi merupakan salah satu syarat utama bagi kemajuan suatu bangsa. Upaya-upaya dilakukan dalam berbagai kompetisi baik nasional maupun internasional, salah satunya melalui Kompetisi Sains Nasional (KSN) yang dilaksanakan setiap tahun. Salah satu bidang yang diikuti oleh siswa SMA N 1 Prambanan adalah Kimia. Kimia merupakan ilmu tentang materi, sifatnya, strukturnya, perubahan/reaksinya serta energi yang menyertai perubahan tersebut. Mata Pelajaran kimia selama ini dianggap momok yang menakutkan oleh siswa. Untuk memperoleh gelar juara pada ajang KSN diperlukan persiapan yang maksimal dalam bimbingan kepada siswa serta motivasi belajar yang besar harus ditumbuhkan dalam pribadi siswa Pelaksanaan kegiatan pendampingan persiapan KSN bidang Kimia diawali dengan memberi motivasi belajar kepada siswa dan dilanjutkan dengan pembahasan soal-soal KSN kimia. Berbagai manfaat dari kerjasama dan kolaborasi dapat dirasakan oleh siswa yaitu siswa dapat pengalaman belajar dari pendamping yang bervariasi, merasakan lingkungan belajar yang baru yakni di kampus. Selain itu siswa juga memperoleh sumber belajar yang lebih banyak.