bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teriflunomide
Authors: Cada Dennis J. , Demaris Kendra , Levien Terri L. , Baker Danial E. 
Published: March 2013

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. Subscribers to The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. A drug class review is now published monthly with The Formulary Monograph Service. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The March 2013 monograph topics are apixaban, bedaquiline, raxibacumab, teduglutide, and loxapine inhalation. The DUE/MUE is on apixaban.
Inhaled Corticosteroid Metered-Dose Inhalers: How Do Variations in Technique for Solutions Versus Suspensions Affect Drug Distribution?
Authors: Robinson Christie A , Tsourounis Candy 
Published: March 2013

OBJECTIVE To assess the literature that evaluates how variations in metereddose inhaler (MDI) technique affect lung distribution for inhaled corticosteroids (ICSs) formulated as MDI suspensions and solutions. DATA SOURCES PubMed (up to November 2012) and Cochrane Library (up to November 2012) were searched using the terms metered-dose inhalers, HFA 134a, Asthma/*drug therapy, and inhaled corticosteroids. In addition, reference citations from publications identified were reviewed. STUDY SELECTION AND DATA EXTRACTION All articles in English from the data sources that assessed MDI technique comparing total lung distribution (TLD) of MDI solutions or suspensions formulated with ICSs were included in the review. Five relevant studies were identified. DATA SYNTHESIS Five controlled studies compared how variations in MDI technique affect TLD for ICS MDI solutions with suspensions. MDI solutions resulted in greater TLD compared with larger particle MDI suspensions. Delayed or early inspiration upon device actuation of MDI solutions resulted in less TLD than coordinated actuation, but with a 3- to 4-times greater TLD than MDI suspensions inhaled using a standard technique. A sixth study evaluated inspiratory flow rates (IFR) for small, medium, and large particles. Rapid and slow IFRs resulted in similar TLD for small particles, while far fewer particles reached the airways with medium and large particles at rapid, rather than slow, IFRs. CONCLUSIONS Based on the literature evaluated, standard MDI technique should be used for ICS suspensions. ICS MDI solutions can provide a higher average TLD than larger-particle ICS suspensions using standard technique, discoordinated inspiration and medication actuation timing, or rapid and slow IFRs. ICS MDI solutions allow for a more forgiving technique, which makes them uniquely suitable options for patients with asthma who have difficultly with MDI technique.
Prevalence and Risk of Potential Cytochrome P450–Mediated Drug-Drug Interactions in Older Hospitalized Patients with Polypharmacy
Authors: Doan Julie , Zakrzewski-Jakubiak Hubert , Roy Julie , Turgeon Jacques , Tannenbaum Cara 
Published: March 2013

BACKGROUND As rates of polypharmacy rise and medication regimens become more complex, the risk of potential cytochrome P450 (CYP)–mediated drug-drug interactions (DDIs) is a growing clinical concern for older adults. objective: To determine the prevalence of potential CYP-mediated DDIs in older hospitalized adults with polypharmacy and analyze the relationship between the number of drugs dispensed and the probability of these interactions in this high-risk population. METHODS A prospective 16-week cohort study was conducted among consecutive new patients aged 65 years and older with polypharmacy (>5 drugs) admitted to a community hospital. The medication profiles of these patients were analyzed with a new multidrug cytochrome-specific software program. The prevalence of potential CYP-mediated DDIs was determined, with the probability calculated as a function of the number of medications dispensed using multivariate Poisson regression adjusted for age and sex. Comparative performance of the software program and a standard 2-drug alert program for detecting these DDIs was evaluated using the Wilcoxon-Mann-Whitney rank-sum test. Pharmacists' decisions to recommend medication adjustment based on the probability of CYP-mediated DDIs were recorded. RESULTS The prevalence of potential CYP-mediated DDIs detected among 275 older adults with polypharmacy was 80%. The probability of at least 1 CYP-mediated DDI was 50% for persons taking 5–9 drugs, 81% with 10–14 drugs, 92% with 15–19 drugs, and 100% with 20 or more drugs. Addition of each medication to a 5-drug regimen conferred a 12% increased risk of a potential CYP-mediated DDI after adjustment for age and sex (OR 1.12; 95% CI 1.09–1.14). The multidrug software identified a median increase of 3 (95% CI 2.5–3.5) potential CYP-mediated DDIs per patient, compared to use of the standard 2-drug alert software. Pharmacists targeted patients for medication adjustment or close clinical monitoring in 23% of cases. CONCLUSIONS The prevalence of potential CYP-mediated DDIs is high in geriatric patients with polypharmacy. The risk of DDIs increases as a function of the number of medications dispensed. Pharmacists' decision to intervene for potential CYP-mediated DDIs depends on clinical judgment in addition to the output from drug alert software programs, but may be facilitated by a single multicomponent, multidrug potential CYP-mediated DDI assessment.
Cardiac Troponin Assay Classification by Both Clinical and Analytical Performance Characteristics: A Study on Outcome Prediction
Authors: Venge Per , Lindahl Bertil 
Published: March 2013

BACKGROUND
Cardiac troponin assays have been classified according to whether they measure the 99th percentile concentration of a healthy reference population with imprecision (expressed as CV) of ≤10%, between 10% and 20%, or &gt;20%. Assays in these categories have been deemed “guideline acceptable,” “clinically usable,” or “not acceptable,” respectively. We compared four widely used “clinically usable” cardiac troponin I (cTnI) assays with an assay designated “not acceptable” for accuracy in predicting the clinical outcome of death.

METHODS
Blood was collected from 259 men and 249 women, mean (SD) age 68.8 (17.8) and 70.2 (17.8) years, respectively, admitted to the emergency department for suspected myocardial infarction. We measured cTnI by the Access, Architect, i-Stat, Stratus CS, and VIDAS assays. Deaths in this population were recorded over a 31-month period.

RESULTS
We found VIDAS cTnI assay measurement CVs of 10% and 20% at concentrations of 0.04 and 0.02 μg/L, respectively. Comparing at the 10% CV cutoff concentration, VIDAS cTnI was less sensitive than the Access and Architect assays (P &lt; 0.001) but more sensitive than i-Stat (P &lt; 0.001) and Stratus CS (P &lt; 0.001) in identifying patients with poor outcomes. At the 20% CV cutoff, the VIDAS assay was equivalent to the other assays in identifying patients with poor outcomes.

CONCLUSIONS
For outcome prediction, the VIDAS cTnI assay was clinically equivalent or superior to other cTnI assays judged to be acceptable from a pure analytical standpoint. Thus, comparison of cardiac troponin assays should consider not only analytical performance, but also clinical performance characteristics.
The Organization of Prefrontal-Subthalamic Inputs in Primates Provides an Anatomical Substrate for Both Functional Specificity and Integration: Implications for Basal Ganglia Models and Deep Brain Stimulation
Authors: Haynes William I. A. , Haber Suzanne N. 
Published: March 2013

The identification of a hyperdirect cortico-subthalamic nucleus connection highlighted the important role of the subthalamic nucleus (STN) in regulating behavior. However, this pathway was shown primarily from motor areas. Hyperdirect pathways associated with cognitive and motivational cortical regions are particularly relevant given recent data from deep brain stimulation, both for neurologic and psychiatric disorders. Our experiments were designed to demonstrate the existence and organization of prefrontal-STN projections, help delineate the “limbic” STN, and determine whether convergence between cortico-STN fibers from functionally diverse cortical areas exists in the STN. We injected anterograde tracers in the ventromedial prefrontal, orbitofrontal, anterior cingulate, and dorsal prefrontal cortices ofMacaca nemestrinaandMacaca fascicularisto analyze the organization of terminals and passing fibers in the STN.Results show a topographically organized prefrontal hyperdirect pathway in primates. Limbic areas project to the medial tip of the nucleus, straddling its border and extending into the lateral hypothalamus. Associative areas project to the medial half, motor areas to the lateral half. Limbic projections terminated primarily rostrally and motor projections more caudally. The extension of limbic projections into the lateral hypothalamus, suggests that this region be included in the STN. A high degree of convergence exists between projections from functionally diverse cortical areas, creating potentially important interfaces between terminal fields. Taken together, the results provide an anatomical substrate to extend the role of the hyperdirect pathway in models of basal ganglia function, and new keys for understanding deep brain stimulation effects on cognitive and motivational aspects of behavior.
Thermoelectric behaviour of p- and n- type Ti-Ni-Sn half Heusler alloy variants and their amorphous equivalents
Authors: Zhu Song , Vitta Satish , Tritt Terry M. 
Published: March 2013

ABSTRACTTi-Ni-Sn type half-Heusler alloys which have the versatility to be either p- or n-type depending on the type of substitution, have been synthesized and investigated in the present work. The added advantage of doping them with multiple elements is that they will be amenable to bulk amorphous phase formation. The hole doped alloys were predominantly single phase with a cubic structure, while the electron doped alloys were found to have minor additional phases. All the alloys exhibit extremely weak metallic-like or degenerate semiconductor transport behaviour in the temperature range 20 K to 1000 K. The resistivity of p-type alloys exhibits semi-metallic-to-semiconducting transition at ∼ 500 K while the n-type alloys exhibit a weak metallic-like behaviour in the complete temperature range. The Seebeck coefficient has strong temperature dependence with a maximum of 45 μV K−1 in the temperature range 600-700 K in the p-type alloys. The n-type alloys however exhibit a linear variation of the Seebeck coefficient with temperature. The total thermal conductivity of the alloys increases with increasing temperature without any peak at low temperatures indicating significant disorder induced scattering. The p-type alloys have the lowest thermal conductivity compared to the n-type alloys. These alloys become amorphous after pulsed laser deposition except one alloy which exhibits compensated transport behaviour.
Grazing Incidence X-ray Topographic Studies of Threading Dislocations in Hydrothermal Grown ZnO Single Crystal Substrates
Authors: Zhou Tianyi , Raghothamachar Balaji , Wu Fangzhen , Dudley Michael 
Published: March 2013

ABSTRACTZnO single crystal substrates grown by the hydrothermal method have been characterized by grazing incidence X-ray topography using both monochromaticand whitesynchrotron X ray beams.11$\bar 2$4 reflection wasrecorded from the (0001) wafers and the different contrast patterns produced by different threading defects were noted. To uniquely identify the Burgers vectors of these threading dislocation defects, we use raytracingsimulation to compare with observed defect contrast. Our studies showed that threading screw dislocations are not commonly observed.Most threading edge dislocationshavetheBurgers vector of1⁄3[2$\bar 1$$\bar 1$0] or1⁄3[12$\bar 2$10]and a density of 2.88×104/cm2.
Triggered Cell Release from Shellac-Cells Composite Microcapsules
Authors: Hamad Shwan A. , Stoyanov Simeon D. , Paunov Vesselin N. 
Published: March 2013

ABSTRACTWe have fabricated novel shellac-cells composite microcapsules capable of pH-stimulus induced release of cells in a narrow pH range. The microcapsules were produced with yeast cells as a model for probiotics which were co-precipitated from an aqueous solution of ammonium shellac doped with pH-sensitive polyelectrolytes. The yeast cells in the composite shellac-cell microcapsules retained their viability even when treated with aqueous solutions of very low pH and subjected to shear stress. We studied the pH triggered release of cells from these microcapsules and measured their disintegration times. These microcapsules showed versatile responses ranging from slow release to explosive swelling at higher pH depending on the type and concentration of the polyelectrolyte integrated in the shellac microcapsules. We also observed growth-triggered release of cells from these microcapsules upon exposure to culture media. In both cases the cells retained their viability following their release from the microcapsules into the aqueous solution.
Microfluidics via Controlled Imbibition
Authors: Jokinen Ville , Franssila Sami 
Published: March 2013

ABSTRACTStrategies for controlled imbibition utilizing both topographical cues as well as patterned surface chemistries are presented. Triangle-like microstructures were used for directional wetting of liquids into a limited sector of the surface. Chemical patterns on top of a nanopillar geometry allowed the patterning of both water and oil droplets. Applications of controlled imbibition in dried droplet mass spectrometry as well as liquid-liquid extraction are also presented.
Spider silk morphology for responsive materials
Authors: Guan Juan , Porter David , Vollrath Fritz 
Published: March 2013

ABSTRACTThis study reveals that an “old” mechanism for shape memory in oriented polymers is in fact just one separate contribution for “supercontraction” in Nephila spider major ampulate silks. When Nephila spider silks are in contact with liquid water, they “super”-contract up to 28% of the original stretched length. However, we discovered that under glass transition conditions these silks only relax with a maximum shrinkage of 13%, and this phenomenon is defined as Tg-contraction. Structural components permanent order (PO), permanent disorder (PD), meta order (MO) and meta disorder (MD) were proposed from the primary amino-acid sequence of the silk protein to explain morphological changes in the two contraction phenomena: MD contributes 13% of the full supercontraction and contributes to Tg-contraction; whereas MO (the proline-containing motifs) contributes the rest for the full super-contraction and does not contribute to Tg-contraction. The morphology in Nephila spider silk structure suggests two separate mechanisms to generate the shape memory effect in synthetic polymers.
Single polynomials that correspond to pairs of cyclotomic polynomials with interlacing zeros
Authors: McKee James , Smyth Chris 
Published: March 2013

Abstract
We give a complete classification of all pairs of cyclotomic polynomials whose zeros interlace on the unit circle, making explicit a result essentially contained in work of Beukers and Heckman. We show that each such pair corresponds to a single polynomial from a certain special class of integer polynomials, the 2-reciprocal discbionic polynomials. We also show that each such pair also corresponds (in four different ways) to a single Pisot polynomial from a certain restricted class, the cyclogenic Pisot polynomials. We investigate properties of this class of Pisot polynomials.
Galois realizability of groups of orders p
5 and p
6
Authors: Michailov Ivo 
Published: March 2013

Abstract
Let p be an odd prime and k an arbitrary field of characteristic not p. We determine the obstructions for the realizability as Galois groups over k of all groups of orders p
5 and p
6 that have an abelian quotient obtained by factoring out central subgroups of order p or p
2. These obstructions are decomposed as products of p-cyclic algebras, provided that k contains certain roots of unity.
Reconstruction of the probability density function by means of the degree of polarization for one-photon mixed states
Authors: Michalik Lukasz , Domanski Andrzej 
Published: March 2013

Abstract
In this paper the authors discuss an alternative way for reconstructing one-photon mixed states of a partially polarized optical field. The task is to represent the probability density distribution describing these kind of states with the Stokes parameters which also characterize the effective state of polarization. These parameters can be measured by means of the degree of polarization with an experimental setup containing a rotating linear polarizer and a circular polarizer. A thought experiment is presented which assumes that the measurement is undertaken on an analyzed beam coupled with a reference beam containing photons polarized in a well-known way. The method discussed in the paper is an alternative for the most commonly used quantum tomography approach.
Synthesis of novel fluorene-functionalised nanoporous silica and its luminescence behaviour in acidic media
Authors: Yadavi Marzieh , Badiei Alireza , Ziarani Ghodsi , Abbasi Alireza 
Published: March 2013

AbstractFluorene-functionalised nanoporous silica (FL-NH2-SBA-15) was prepared using the post-synthesis grafting method of SBA-15. The material thus obtained was characterised by means of small- and wide-angle X-ray diffraction, nitrogen adsorption-desorption, Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis, and elemental analysis. The results showed that the organised structure is preserved after the post-grafting procedure. Surface area and pore-size decreased by attaching functional groups to the pore surface. In addition, the pore volume was reduced with functionalisation. The amount of fluorene grafted onto the surface of SBA-15 was 0.55 mmol with a yield of approximately 46 %. The emission spectra of FL-NH2-SBA-15 in acidic media were studied and are discussed in detail. The structural change between FL-NH2-SBA-15 and the protonated form might be an effective candidate for acid-dependent molecular-sensor models for advanced application in molecular sensors in the future.
Effective immobilisation of lipase to enhance esterification potential and reusability
Authors: Kumar Ashok , Sharma Vikrant , Sharma Prachi , Kanwar Shamsher 
Published: March 2013

AbstractA commercial lipase, “Lipolase T100”, was immobilised onto silica by means of physical adsorption. The silica-bound lipase was subsequently exposed to 1 vol. % glutaraldehyde (pentane-1,5-dial). The silica was loaded repeatedly with the Lipolase T100 in 0.05 M Tris buffer (pH 8.5) until saturation was achieved. During the 1st, 2nd, 3rd, 4th, and 5th cycles of loading of silica with the enzyme, the protein-binding on the silica achieved 51.73 %, 48.27 %, 26.92 %, 10.73 %, and 4.29 %, respectively. The synthesis of methyl salicylate (methyl 2-hydroxybenzoate) and linalyl ferulate (3,7-dimethylocta-1,6-dien-3-yl 4-hydroxy-3-methoxycinnamate) carried out at 45°C under shaking with mole ratios of 200 mM of acid and 500 mM alcohol in DMSO using 15 mg mL−1 of hyper-activated biocatalyst resulted in yield(s) of 77.2 % of methyl salicylate and 65.3 % of linalyl ferulate in the presence of molecular sieves. The hyper-activated biocatalyst was more efficient than the previously reported silica-bound lipase with minimum leaching of the enzyme from the reaction mixture. The K m and V max of the free (0.142 mM and 38.31 μmol min−1 mL−1, respectively) and silica-bound lipase (0.043 mM and 26.32 μmol min−1 mg−1, respectively) were determined for the hydrolysis of p-NPP. During repeated esterification studies using silica-bound lipase, yields of 50.1 % of methyl salicylate after the 5th cycle, and 53.9 % of linalyl ferulate after the 7th cycle of esterification were recorded. In the presence of molecular sieves (30 mg mL−1) in the reaction mixture, the maximum syntheses of methyl salicylate (77.2 %) and linalyl ferulate (65.3 %) were also observed. In a volumetric batch scale-up, when the reaction volume was increased to 50 mL, 44.9 % and 31.4 % yields of methyl salicylate and linalyl ferulate, respectively, were achieved.
Validity and Sensitivity to Change of Patient-Reported Pain and Disability Measures for Elbow Pathologies
Authors: Vincent Joshua I. , MacDermid Joy C. , King Graham J.W. , Grewal Ruby 
Published: March 2013

Study Design Prospective cohort study. Objective To evaluate the internal consistency, concurrent construct validity, longitudinal validity, sensitivity to change, and factor structure of the Patient-Rated Elbow Evaluation form (PREE), the patient-reported form of the American Shoulder and Elbow Surgeons Elbow Questionnaire (pASES-e), and the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH) in a diverse group of patients who had surgery for various elbow pathologies. Background Measuring functional outcomes after surgical procedures of the elbow requires valid patient-reported pain and disability questionnaires. The PREE, the pASES-e, and the DASH are commonly used questionnaires. There is, however, insufficient evidence available concerning their validity and sensitivity to change. Methods Data were prospectively collected from 128 patients (mean ± SD age, 46.5 ± 12.8 years) post-elbow surgery. Patients completed the PREE, the pASES-e, the DASH, and the Medical Outcomes Study 36-Item Short-Form Health Survey at baseline (first visit after surgery) and 6 months postsurgery. Concurrent construct validity, longitudinal validity, sensitivity to change, and factor structure were analyzed. Results Concurrent construct validity was demonstrated by confirmation of expected relationships; the strongest correlations were observed between the PREE pain score, the PREE total score, the pASES-e pain score, and the DASH score (r = 0.73–0.87). The pASES-e function score correlated the least with other constructs. Longitudinal validity demonstrated similar findings: the pASES-e pain change score and PREE change score were most strongly correlated, and the pASES-e function change score and DASH change score were moderately to weakly correlated. All 3 patient-reported questionnaires demonstrated a large effect size and standardized response means greater than 1.0. Structural validity was supported for the PREE (R2 = 77.2%, 4 factors) and the pASES-e (R2 = 74.4%, 4 factors), but not for the DASH (R2 = 71.3%, 5 factors). Conclusion The PREE, the pASES-e, and the DASH have acceptable validity and sensitivity to change. The pASES-e function subscale is the least sensitive to change and is less correlated to other measures. J Orthop Sports Phys Ther 2013;43(4):263–274. Epub 13 March 2013. doi:10.2519/jospt.2013.4029