bluuebunny/crossref_metadata_2025_split huggingface dataset:
Somatic IDH1 mutation in a pituitary adenoma of a patient with Maffucci syndrome
Authors: Hao Shuyu , Hong Christopher S. , Feng Jie , Yang Chunzhang , Chittiboina Prashant , Zhang Junting , Zhuang Zhengping 
Published: October 2015

Maffucci syndrome is a rare disease characterized by multiple enchondromas and soft-tissue hemangiomas. Additionally, neuroendocrine tumors including pituitary adenomas have been described in these patients. The underlying genetic etiology lies in somatic mosaicism of mutations in isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2). This report describes a patient with Maffucci syndrome who presented with intracranial tumors of the skull base and suprasellar region. The patient underwent resection of both intracranial tumors, revealing histopathological diagnoses of chondrosarcoma and pituitary adenoma. DNA sequencing of the tumors was performed to identify common IDH1/2 mutations. Clinical, radiological, and biochemical assessments were performed. Genotypic studies used standard Sanger sequencing in conjunction with a target-specific peptide nucleic acid to detect IDH1 mutations in tumor tissues. DNA sequencing demonstrated identical IDH1 mutations (c.394C > T) in both tumors.
To the authors’ knowledge, this report provides the first genetic evidence for the inclusion of pituitary adenomas among tumors characterizing Maffucci syndrome. In patients who are newly diagnosed with Maffucci syndrome, it is appropriate to monitor for development of pituitary pathology and neuroendocrine dysfunction.
The Longitudinal Course of Fatigue in Rheumatoid Arthritis: Results from the Norfolk Arthritis Register
Authors: Druce Katie L. , Jones Gareth T. , Macfarlane Gary J. , Verstappen Suzanne M.M. , Basu Neil 
Published: October 2015

Objective.Fatigue is common and burdensome in rheumatoid arthritis (RA). Despite RA fatigue progression varying significantly between individuals in practice, existing longitudinal analyses only examine symptom advancement on a population level. This study aimed to determine fatigue trajectories at an individual level and to characterize those patients with the poorest prognosis, with a view to enabling earlier interventions.Methods.Patients with RA reporting clinically relevant baseline fatigue (≥ 20 mm on a 0–100 mm visual analog scale) were identified from a longterm inflammatory polyarthritis cohort (the Norfolk Arthritis Register). Fatigue changes from baseline to 1- and 4-year followups were calculated, and sex-stratified group-based trajectory modeling (GBTM) determined trajectories of the symptom between which baseline characteristics were compared.Results.Among 338 patients, only minimal average changes were observed between recruitment to 1 year (6.0 mm, SD 26.9) and 4 years (5.5 mm, SD 29.3). This was despite 45.6% and 40.7% of participants reporting clinically significant improvements (≥ 10 mm) at these respective followups. GBTM revealed varied trajectories of fatigue, which for both sexes consisted of Improved (men, n = 48 and women, n = 81) or persistent Moderate-high paths (n = 54, n = 105), and further included a persistent High trajectory in women (n = 50). Participants who followed persistent trajectories were best distinguished from improvers by patient-reported rather than demographic or clinical variables.Conclusion.Among patients with RA presenting with clinically relevant fatigue, distinct longitudinal symptom trajectories were identified on an individual level despite nominal average changes in fatigue on a group level. It is possible to identify and characterize subgroups of participants who report persistent fatigue and should therefore be targeted to receive future fatigue-alleviating interventions.
COMPARISON OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN HEALTHY COMMUNITY HOSPITAL VISITORS[CA-MRSA] AND HOSPITAL STAFF [HA-MRSA]
Authors: Pathare Nirmal A , Pathare Anil 
Published: October 2015

Background: The prevalence of community associated methicillin resistant Staphylococcus aureus [CA-MRSA] in unknown in Oman.Methods: Nasal and cell phones swabs were collected from hospital visitors and health-care workers on sterile polyester swabs and directly inoculated onto a mannitol salt agar containing oxacillin, allowing growth of methicillin-resistant microorganisms. Antibiotic susceptibility tests were performed using Kirby Bauer’s disc diffusion method on the isolates. A brief survey questionnaire was requested be filled to ascertain the exposure to known risk factors for CA-MRSA carriage.Results: Overall, nasal colonization with CA-MRSA was seen in 34 individuals (18%, 95% confidence interval [CI] =12.5%-23.5%), whereas, CA-MRSA was additionally isolated from the cell phone surface in 12 participants (6.3%, 95% CI =5.6%-6.98%). Nasal colonization prevalence with HA-MRSA was seen in 16 individuals (13.8%, 95% confidence interval [CI] =7.5%-20.06%), whereas, HA-MRSA was additionally isolated from the cell phone surface in 3 participants (2.6%, 95% CI =1.7-4.54). Antibiotic sensitivity was 100% to linezolid and rifampicin in the CA-MRSA isolates. Antibiotic resistance to vancomycin and clindamycin varied between 9-11 % in the CA-MRSA isolates. There was no statistically significant correlation between CA-MRSA nasal carriage and the risk factors (P>0.05, Chi-square test).Conclusions: The prevalence of CA-MRSA in the healthy community hospital visitors was 18 % (95% CI, 12.5% to 23.5%) as compared to 13.8% [HA-MRSA] in the hospital health-care staff. In spite of a significant prevalence of CA-MRSA, these strains were mostly sensitive. Recommendation the universal techniques of hand washing, personal hygiene and sanitation are thus warranted.
BACTERIAL INFECTIONS FOLLOWING SPLENECTOMY FOR MALIGNANT AND NONMALIGNANT HEMATOLOGIC DISEASES
Authors: Leone Giuseppe , Pizzigallo Eligio 
Published: October 2015

Splenectomy, while often necessary in otherwise healthy patients after major trauma, find its primary indication for patients with an underlying malignant or nonmalignant hematologic diseases. Indications of splenectomy for hematologic diseases have been reducing in the last few years, due to improved diagnostic and therapeutic tools. In high-income countries, there is a clear decrease over calendar time in the incidence of all indication splenectomy except nonmalignant hematologic diseases. However, splenectomy, even if with different modalities including laparoscopic splenectomy and partial splenectomy, continue to be a current surgical practice both in nonmalignant hematologic diseases, such as Immune Thrombocytopenic Purpura (ITP), Autoimmune Hemolytic Anemia (AIHA), Congenital Hemolytic Anemia such as Spherocytosis, Sickle Cell Anemia and Thalassemia and Malignant Hematological Disease, such as lymphoma. Today millions of people in the world are splenectomized. Splenectomy, independently of its cause, induces an early and late increase in the incidence of venous thromboembolism and infections. Infections remain the most dangerous complication of splenectomy. After splenectomy, the levels of antibody are preserved but there is a loss of memory B cells against pneumococcus and tetanus, and the loss of marginal zone monocytes deputed to immunological defense from capsulated bacteria. Commonly, the infections strictly correlated to the absence of the spleen or a decreased or absent splenic function are due to encapsulated bacteria that are the most virulent pathogens in this set of patients. Vaccination with polysaccharide and conjugate vaccines again Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis should be performed before the splenectomy. This practice reduces but does not eliminate the occurrence of overwhelming infections due to capsulated bacteria. At present, most of infection found in splenectomized patients are due to Gram-negative (G-) bacteria. The underlying disease is the most important factor in determining the frequency and severity of infections.So, splenectomy for malignant diseases has the major risk of infections.Keywords: Splenectomy, Infections, Bacteria,Str. Pneumoniae, Vaccine.
Avances en Sistemas de Información Espacial 3D. Aplicaciones en patrimonio y arqueología virtual
Authors: Robles Ortega María Dolores , Ortega Alvarado Lidia , Feito Higueruela Francisco Ramón 
Published: October 2015

<p>Large point clouds from radars and these-dimensional scanners are commonly used in Archaeology. However, in most cases these models cannot be properly integrated and used in software such as heritage management due to its large size. Therefore, some tools to make this management easier and optimize the processing are needed. In this work, we propone the integration between OpenVDB and GRASS in a C++ module to combine the widen functionality of GRASS GIS with the 3D models management efficiency of OpenVDB. Specifically, this application is used to combine the topographic information of a city with the 3D models of the most significant buildings. This application can be useful for both current cities as well as for virtual reconstruction of existing villages in the olden days and currently disappeared. </p>
Functional Deficits and Quality of Life Among Cancer Survivors: Implications for Occupational Therapy in Cancer Survivorship Care
Authors: Hwang Eric J. , Lokietz Nicole C. , Lozano Rachel L. , Parke Megan A. 
Published: October 2015

Abstract
This study aimed to explore functional deficits and perceived quality of life (QoL) among cancer survivors. Sixty-six participants completed the Post Cancer Outcome Survey developed for the purpose of this study. The results indicated (1) modest to moderate degrees of functional deficits in 28 of the 70 items measuring areas of occupation, performance skills, body functions, and psychosocial well-being within the first year after cancer treatment; (2) significantly lower perceived QoL during the first year of survivorship compared with that before diagnosis, at present, and 5 yr hereafter (p &lt; .001); (3) significant moderate negative correlations between the reported functional deficits and QoL (rs = –.45 to –.57); and (4) a very low percentage of participants (4.5%) receiving occupational therapy during the first year posttreatment. Functional difficulties and compromised QoL identified in this study indicate the need for occupational therapy among cancer survivors. Increasing clients’ awareness of occupational therapy for postcancer care is also suggested.
Perspectives on the Use of Standardized Parents to Teach Collaboration to Graduate Occupational Therapy Students
Authors: Cahill Susan M. 
Published: October 2015

AbstractOBJECTIVE. Pediatric occupational therapy practitioners interview parents on a daily basis to gain important patient information and develop collaborative intervention goals. A standardized parent experience was developed to help master’s-level occupational therapy students gain the skills needed to interview parents after their child’s traumatic injury. This article describes the pedagogical approach used to develop the standardized parent experience and reports the students’ general perspectives related to this assignment.METHOD. Outcome data were collected through focus groups (n = 9) and document review (n = 12) and then analyzed for themes.RESULTS. Two main themes emerged from the data: It felt real and It helped me to think deeper.CONCLUSION. A standardized parent experience may help occupational therapy students develop the habits of mind associated with collaboration.
Modelos de impacto en la agricultura teniendo en cuenta los escenarios de la agricultura del cambio climático
Authors: Vázquez Montenegro Ranses José , Zarabozo Odil Durán , Baca Marcio 
Published: October 2015

La presente reseña o recopilación de estudios realizados en Cuba y Nicaragua, tiene como propósito examinar, los impactos potenciales del cambio climático sobre el sector agropecuario mediante el uso de la modelación, con el fin de brindar elementos que puedan tomarse en cuenta para la formulación de políticas agropecuarias y ambientales, ya que conocer los posibles impactos del cambio climático, es un primer paso hacia la acción eficaz. Se analizan los posibles impactos de las variaciones de las variables climáticas sobre el sector agropecuario, sobre algunos de los cultivos más importantes. Asimismo se contabilizan los impactos económicos a través escenarios climáticos futuros. El estudio en el sector de agricultura arrojó una amplia gama de resultados que abarcan tanto consecuencias perjudiciales como beneficiosas, en función de que los niveles del efecto de fertilización por CO2 (estimados en los laboratorios) se alcancen en la práctica para las plantas de ciclo fotosintético C3.
Charcot-Marie-Tooth disease type I diagnosed in a 5-year-old boy after vincristine neurotoxicity, resulting in maternal diagnosis
Authors: Olek Michael J , Bordeaux Bryan , Leshner Robert T 
Published: October 2015

Abstract
Charcot-Marie-Tooth disease type 1, also known as hereditary motor sensory neuropathy type 1, is an uncommon autosomal dominant disease that causes destruction of peripheral nerves with a varied clinical course, but often leads to muscle weakness. If the peroneal muscle is involved, the patient may develop a characteristic slapping gait. The dose-limiting side effect of the chemotherapeutic agentvincristine is usually its neurotoxicity. We report the case of a 5-year-old patient with leukemia who developed an acute polyneuropathy after treatment with vincristine. Charcot-Marie-Tooth disease type 1 was diagnosed in the patient and, subsequently, in his mother only after vincristine toxicity was observed.
Health hazards reported by international travelers
Authors: Licciardone John C. 
Published: October 2015

Abstract
International travel projections suggest that physicians will be increasingly involved in cotmseling their traveling patients on the prevention of health hazards. A mail survey of 121 returning international travelers indicated that their leading problems involved drinking water (odds ratio [OR], 19.4; 95% confidence interval [CI], 9.6 to 39.1), sanitation (OR, 13.8; 95% CI, 6.9 to 27.5), jet lag (OR, 12.4; 95% CI, 6.2 to 24.6), and food (OR, 9.5; 95% CI, 4.8 to 18.8). Medication for treatment of travelers' diarrhea and countermeasures for jet lag were not significantly associated with better outcomes. Compliance with malaria chemoprophylaxis was greater than previously reported.
Psychogenic stridor: A cause of acute upper airway obstruction
Authors: Carbone Jared , Litman Ronald S 
Published: October 2015

Abstract
A 17-year-old boy was seen in the emergency department with signs and symptoms of acute upper airway obstruction, closely resembling epiglottitis. Inunediate management consisted of induction of general anesthesia with spontaneous ventilation. Because no organic pathologic process was found, and in combination with subsequently known psychosocial stressors, a diagnosis of psychogenic stridor, a conversion disorder, was made. Conversion disorders may be seen by the busy family practitioner or pediatrician and are frequently underdiagnosed.
Visualization technology in medical education
Authors: Faao Sherman Gorbis, , Hallgren Richard C 
Published: October 2015

Abstract
Visualization technology offers the possibility of profoundly changing the way in which osteopathic medical students assimilate basic osteopathic principles by giving them the ability to interactively explore biomechanical components of the musculoskeletal system, and to investigate the effects that changes in physical properties can have on functionality. The authors are developing a multiple-volume series of computer-assisted learning modules that use three-dimensional, visualization technology to enhance the acquisition of knowledge and skills necessary for clinical evaluation and treatment of the lumbar and cervical spines. These materials, designed to serve as an adjunct to teaching strategies that faculty are currendy using, are available to students on campus through the Kobiljak Resource Center at Michigan State University College of Osteopathic Medicine (MSUCOM) and via the Internet (http://hal.binl.msu.edulEdTech) to individuals and groups who are physically removed from the Michigan State University campus. In addition to addressing needs in undergraduate and graduate medical education, these osteopathic materials, delivered to users via CD-ROM, have been approved for obtaining Category 1-B CME credits (http://hal.bim.msu.edulcme).Itis anticipated that the use of these materials will facilitate understanding of static and dynamic relationships among physical components of the musculoskeletal system, thus contributing to ongoing efforts to develop and maintain physician, faculty, and student expertise in areas that are uniquely osteopathic. Although initial efforts were restricted to the cervical and lumbar spines, future modules will include other regions of the body. The ultimate goal is to enable students to visualize the effects of pathologic processes as they interactively control an articulation in three-dimensional space.
The role of physical activity in the management of obesity
Authors: Harris Jeffrey E 
Published: October 2015

Abstract
Sedentary lifestyle is associated with obesity and obesity-related chronic diseases. Increased physical activity can produce clinically significant changes in body composition and a reduction in risk of obesity-related chronic diseases in obese people. Because a great proportion of a primary care physician's patient population will be obese, it is essential that physicians know the scientific facts about the role of physical activity in the treatment of obesity and how to effectively prescribe it. This article summarizes significant research .conclusions about the relationship between physical activity, obesity, and health. It also provides practical strategies for helping obese patients integrate physical activity into their lives.
Advances in the understanding and treatment of obesity
Authors: Still, Christopher D 
Published: October 2015

Abstract
The epidemic of obesity in the United States has major consequences for society. Healthcare proViders need to have an appreciation for obesity's complexity and related multiple comorbid medical problems. This article reviews the epidemiology, definitions, and assessment of obesity with emphasis on its clinical consequences. In addition, current techniques in evaluating and treating the obese patient are also described.
Scripted role play: A technique for teaching sexual history taking
Authors: Schweickert Eileen A , Heeren Allison B 
Published: October 2015

Abstract
Many inexperienced physicians are uncertain as to how to go about gathering a sexual history. They have had courses in basic history taking, but they do not know how to go about obtaining the information in a nonthreatening way. Their opportunities for interaction with real patients have typically been limited. Scripted role play is a very effective method for providing residents with an opportunity to enhance their sexual-history-taking skills. This article describes scripted role play as a teaching method; explains why it is effective for teaching sexual history taking; presents general guidelines for script writing for this purpose; details how to organize a teaching session; and provides some tips for thesession facilitator.
Rheumatoid arthritis and primary care: The case for early diagnosis and treatment
Authors: Calabrese Leonard H. 
Published: October 2015

Abstract
Rheumatoid arthritis is a chronic inflammatory disease that can cause severe pain and disability. Disease management historically was based on a "therapeutic pyramid" in which treatment escalated as symptoms worsened. However, the demonstration of early joint damage in patients with rheumatoid arthritis has emphasized the importance of early identification and treatment. Key features in establishing a diagnosis include joint examinations, assessments of extra-articular manifestations, laboratory tests, and radiologic examinations. Care must be taken to rule outother disorders with symptoms that overlap those of rheumatoid arthritis. Treatment of rheumatoid arthritis typically involves disease-modifying antirheumatic drugs, nonsteroidal anti-inflammatory drugs, and low-dose corticosteroids-often used in combination. A new class of therapeutic agents designed to neutralize inflammatory cytokines has added a new dimension to the therapeutic armamentarium against rheumatoid arthritis. Etanercept, a bioengineered soluble receptor fusion protein that blocks tumor necrosis factor activity, is the first compound in this class to be approved for treatment of patients with refractory rheumatoid arthritis. Therapeutic trials indicate that etanercept can reduce disease activity with relatively few drug-related adverse effects, thus helping persons with rheumatoid arthritis return to more normal, healthy lives.
Revisiting diagenesis on the Ontong Java Plateau: Evidence for authigenic crust precipitation in Globorotalia tumida
Authors: Branson Oscar , Read Elizabeth , Redfern Simon A. T. , Rau Christoph , Elderfield Henry 
Published: October 2015

AbstractThe calcite tests of foraminifera lie in marine sediments for thousands to millions of years, before being analyzed to generate trace element and isotope paleoproxy records. These sediments constitute a distinct physio‐chemical environment from the conditions in which the tests formed. Storage in sediments can modify the trace element and isotopic content of foraminiferal calcite through diagenetic alteration, which has the potential to confound their paleoceanographic interpretation. A previous study of Globorotalia tumida from the Ontong Java Plateau, western equatorial Pacific, found that preferential dissolution of higher‐Mg chamber calcite and the preservation of a low‐Mg crust on the tests significantly reduced whole‐test Mg/Ca and Sr/Ca. Here we revisit specimens with a combination of synchrotron X‐ray computed tomography (sXCT) and electron probe microanalyses to reevaluate the nature of their diagenetic alteration. The dissolution of higher‐Mg calcite with depth was directly observed in the sXCT data, confirming the inference of the previous study. The sXCT data further reveal a thickening of the chemically and structurally distinct calcite crust with depth. We propose that these crusts have a diagenetic origin, driven by the simultaneous dissolution of high‐Mg chamber calcite and precipitation of low‐Mg crust from the resulting modified pore water solution. While the breadth of the study is limited by the nature of the techniques, the observation of both dissolution and reprecipitation of foraminiferal calcite serves to demonstrate the action of two simultaneous diagenetic alteration processes, with significant impacts on the resulting paleoproxy signals.