bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Histopathological Characteristics of Basal Cell Carcinoma in Korean Patients
Authors: Cho Soyun , Kim Myung‐Hwa , Whang Kyu‐Kwang , Hahm Jeong‐Hee 
Published: April 2015

AbstractSeventy‐eight Korean patients with basal cell carcinoma (BCC) between 1984 and 1998 were retrospectively examined at Ewha Womans University Tongdaemun Hospital, Seoul, Korea. We analyzed the annual incidence, age and sex distribution, site of the lesions, clinical appearance, including the proportion of clinically pigmented tumors, modalities of treatment, incidence of recurrence and metastasis of the tumors, the histopathological patterns, and whether solar elastosis, microscopic pigmentation, or adamantinoid feature were associated. The male‐to‐female ratio was 0.902, and the average age of the patients at first examination was 58.2 years. Eighty percent of the tumors occurred on the head and neck, most commonly on the nose (26.9%), followed by the cheek, eyelid, and upper lip. Ulcerated nodules were the most common clinical presentation. Clinically, 55% of the tumors were pigmented. Six tumors recurred; none metastasized. Surgical excision was the most common modality of treatment. The most frequent histopathological pattern was the solid type (60.3%), followed by the superficial (11.5%) and fibrosing (9.0%) types. The occurrence of the superficial type was significantly associated with truncal lesions (p<0.001). Solar elastosis was present in 62.1% of the tumors on the head and neck, compared with 8.3% in those of the trunk and limbs (p<0.001), indicating the significance of sun exposure in the pathogenesis of BCC on exposed areas. Microscopic pigmentation was seen in 69.2% of the tumors. The focal adamantinoid feature was found in 14.1%, which is much higher than the previously reported incidence.
A Case of Lipodystrophia Centrifugalis Abdominalis Infantilis with Morphea
Authors: Ikoma Akihiko , Tanaka Toshihiro , Miyachi Yoshiki 
Published: April 2015

AbstractA 5‐year‐old female developed three depressed lesions sequentially on her left hip, left upper arm and left Achilles tendon; we diagnosed them as lipodystrophia centrifugalis abdominalis infantilis (LCAI). She also developed two sclerotic lesions, at almost the same time, on her left upper arm and left forearm; we diagnosed them as morphea. Clinical and histopathological examination revealed that the LCAI and morphea seen in our case were completely different. Although two other cases of co‐existing LCAI and morphea have already been reported, they were not described in detail and their morphea lesions were adjacent to their LCAI lesions. We herein report a case of LCAI with morphea in which the lesions were not adjacent.
New Technologies toward Dendritic Cell‐Based Cancer Immunotherapies
Authors: Matsue Hiroyuki , Morita Akimichi , Matsue Keiko , Takashima Akira 
Published: April 2015

AbstractImmunologically naive T cells are activated most efficiently or even exclusively by special subsets of antigen presenting cells, termed dendritic cells (DC). Members of the DC family have been identified in virtually all epithelial tissues that are constantly exposed to environmental antigens or infectious microbes. For example, skin is equipped with at least two members of this family, epidermal Langerhans cells (LC) and dermal DC. DC have been shown to play pathogenic roles in several different inflammatory/immunological disorders and protective roles against infectious pathogens and cancer development. In this review article, we will overview the recent progress in the development of DC‐based immunotherapies for the prevention and treatment of cancers.
Vascular Tumors Arising in Port‐Wine Stains: Two Cases of Pyogenic Granuloma and a Case of Acquired Tufted Angioma
Authors: Kim Tae‐Hyun , Choi Eung Ho , Ahn Sung Ku , Lee Sung Hun 
Published: April 2015

AbstractThree female patients affected by intradermal vascular tumors were presented. The lesions were acquired and developed from preexisting port‐wine stains (PWS). Among the three patients observed, two had a pyogenic granuloma (PG) and the third patient had tufted anigomas. As reported earlier, formation of a PG within the lesion of a PWS supports the assumption that arteriovenous anastomoses are associated with its pathogenesis. Occurrence of tufted angioma from a PWS, as well as coexisting but separate PWS, has been reported. However, the tufted angiomas of our patient were located in different sites, one in the PWS and others separate from the PWS. This has never previously been reported.
A Case of Pediatric Behçet's Disease with Intestinal Involvement
Authors: Yamazaki Sayuri , Koyano Taeko 
Published: April 2015

AbstractWe report a 6‐year‐old girl with recurrent oral aphthae, genital and perianal ulcers, and folliculitis‐like erythema followed by intestinal symptoms. No ocular lesions were found. Her ailment was diagnosed as incomplete Behçet's disease with intestinal involvement. According to the literature, pediatric Behçet's disease is characterizesd by a low incidence of ocular lesions and a high incidence of intestinal involvement, as exhibited in this case. As intestinal lesions in pediatric Behçet's disease are often life‐threatening, a barium enema must be given to exclude the possibility of intestinal involvement when pediatric patients with Behçet's disease complain of abdominal pain
Osteo‐nevus of Nanta: A Case Report and Review of the Japanese Literature
Authors: Sasaki Satsuki , Mitsuhashi Yoshihiko , Ito Yoshihiko 
Published: April 2015

AbstractWe reported a 58‐year‐old Japanese male with osteo‐nevus of Nanta on his right cheek. Histological examination revealed nests of nevus cells throughout the entire dermis. Just beneath the nevus in the lower dermis, several basophilic oval‐shaped membranous structures were positive with Kossa stain. No inflammatory infiltrate or foreign‐body granuloma were seen. We reviewed 28 cases of osteo‐nevus of Nanta reported in the Japanese literature and discussed the pathogenesis of ossification in the lesions of nevus cell nevi.
A Case of Metastatic Extramammary Paget's Disease That Responded to Combination Chemotherapy
Authors: Yamazaki Naoya , Yamamoto Akifumi , Wada Takashi , Ishikawa Masashi , Moriya Yoshihiro , Nakanishi Yukihiro 
Published: April 2015

AbstractExtramammary Paget's disease is considered to be a malignant tumor originating from the sweat glands. Some cases of extramammary Paget's disease infiltrate the dermis and metastasize to the regional lymph nodes. No standard treatment has been established for advanced cases. Few previous studies of the treatment for metastatic Paget's disease have revealed an effective regimen. The prognosis of metastasized cases is very poor.We encountered a patient in whom extramammary Paget's disease had metastasized to the lymph nodes beyond the regional lymph nodes and systemic chemotherapy was partially effective. Combination chemotherapy consisted of mitomycin C 3.5 mg/m2 and epirubicin 50 mg/m2 on day 1, vincristine 0.6 mg/m2 on days 1 and 7, cisplatin 30 mg/m2 from days 1 to 3, and 5‐fluorouracil 350 mg/m2 from days 3 to 7. After two courses of chemotherapy, the metastatic lymph nodes decreased in size by more than 90% compared to that before chemotherapy. We defined the treatment effect of this regimen as a partial response (PR). Microscopic examination of the resected lymph nodes revealed replacement of metastatic lesions by fibrous tissue, suggesting a therapeutic effect. Anorexia, alopecia, and leukopenia (neutropenia) have been reported as toxicities, but all were tolerated.Our results may provide useful indications for the management of this tumor. This particular combination chemotherapy is recommended for extramammary Paget's disease patients with systemic nodal metastases.
A Reactive Acrosyringeal Proliferation in a Patient with Ectodermal Dysplasia: Eccrine Syringofibroadenoma‐like Lesion
Authors: Utani Atsushi , Hattori Yukari 
Published: April 2015

AbstractA 33‐year‐old man with ectodermal dysplasia (ED) has suffered from keratotic, exudative, erythematous plaques on the genital area, thighs, and soles since age 17. Verrucous soft nodules in a cobblestone arrangement developed on the erythematous plaque on his left thigh when he was 31 years old. Histologic examination of the verrucous nodules demonstrated that they were composed of anastomosing thin cords of uniform, cuboidal, epithelial cells and a fibrovascular stroma. The changes are indicative of eccrine syringofibroadenoma of Mascaro (ESFA), which has been reported as a neoplasm, a hamartoma, or a nevus. With etretinate treatment, the verrucous nodules completely disappeared within two months. Similar, but much flatter, verrucous lesions recurred and disappeared twice during the subsequent two years period. These verrucous lesions were likely induced by irritation from urine, stool, and/or mechanical friction. This case of ESFA in a patient with ED clearly showed a reactive process which was successfully managed with oral etretinate.
A Case of Unna‐Thost Disease Accompained by Epidermophyton floccosum Infection
Authors: Maruyama Ryuji , Katoh Takuro , Nishioka Kiyoshi 
Published: April 2015

AbstractWe report herein a case of 61‐year‐old man with Unna‐Thost disease (nonepidermolytic hereditary palmoplantar keratoderma) who had been suffering from refractory dermatophyte infection. Diffuse palmoplantar hyperkeratosis developed in his infancy. Coarse scaling, fissures, marked erythema, and nail deformities appeared in his early adult life. Microscopic examination revealed fungal elements in scales and nail particles. Cultures of those scales isolated Epidermophyton floccosum. Genealogical study demonstrated that his mother, sister, brother, daughter, and niece had had similar tylosis, and all of the affected individuals except his daughter had been proved to have E. floccosum or Trichophyton rubrum infection. Oral itraconazole (100mg/day) was highly effective in treating his dermatophytosis without any adverse effects. Scaling, fissures and underlying erythema disappeared within four months.
Erythema Dyschromicum Perstans in Early Childhood
Authors: Lee Sang‐ju , Chung Kee‐Yang 
Published: April 2015

AbstractErythema dyschromicum perstans (EDP) is a rare disorder characterized by asymptomatic, slowly progressive, ash‐gray macular pigmentation of the skin which usually occurs from age 5 through adult life. We have experienced two cases of EDP in children aged 2 and 3, both exceptionally younger than the previously reported cases. We therefore suggest that EDP should be included in the differential diagnosis of pigmentary disorders occurring at an early age.
A Case of Edematous Striae Distensae in Lupus Nephritis
Authors: Lee Ji Ho , Lee Eun Kyoung , Kim Chung Won , Kim Tae Yoon 
Published: April 2015

AbstractA 17‐year‐old girl with systemic lupus erythematosus presented with painful edematous abdominal striae. She had been treated with systemic steroid for the systemic lupus erythematosus. At the time of presentation, she had abruptly gained 10kg due to combined lupus nephritis. The histopathologic finding of the edematous striae distensae included dermal edema with separation of collagen fibers and small fragmented elastic fibers. Edematous striae distensae are uncommon but can develop from the combined effects of glucocorticoid and generalized edema.
Difficulties in Treating Steroid Withdrawal: Intermittent ACTH and Low Dose Systemic Cyclosporin Used to Treat a Senile Erythroderma Patient
Authors: Horiuchi Yasuhiro 
Published: April 2015

AbstractThe tapering or termination of prolonged strong topical and/or systemic corticosteroid application for extensive generalized eczema has adverse effects on the body and thus presents a very difficult situation. The present case is that of a 68‐year‐old man with erythroderma following eczema, whose steroid withdrawal was successfully treated with intermittent ACTH and low dose systemic cyclosporin administration over a period of one year.
Granuloma Annulare in Herpes Zoster Scars
Authors: Ohata Chika , Shirabe Hirotsugu , Takagi Keiichi , Kawatsu Tomoyuki 
Published: April 2015

AbstractA 54‐year‐old Japanese female developed granuloma annulare twice in herpes zoster scars. Soon after the second event, she developed ulcerative colitis, which was well controled by sulfonamides and corticosteroid suppository. She had no history of diabetes mellitus. There was no recurrence of granuloma annulare by June of 1999. Granuloma annulare might have contributed to the complications of ulcerative colitis, although this had not been noticed before.
Cutaneous CD30 (Ki‐1)‐Positive Anaplastic Large Cell Lymphoma Preceded by Hodgkin's Disease
Authors: Terao Hiroshi , Kiryu Hiromaro , Ohshima Koichi , Kikuchi Masahiro , Furue Masutaka 
Published: April 2015

AbstractA 38‐year‐old female was diagnosed as Hodgkin's disease of the axillar lymph nodes, nodular sclerosis type, as evidenced by the presence of Reed‐Sternberg cells positive for CD30 and CD15 and negative for CD3, CD20, and CD45. She achieved complete remission after combination chemotherapy. Two years later, she noticed a red papule on her pubic area without any lymph node involvement. The biopsy specimens showed diffuse proliferation of large‐sized atypical lymphoid cells positive for CD30 and CD45, and negative for CD3, CD20 and CD15. These findings were mostly compatible with CD30 (Ki‐1)‐positive anaplastic large cell lymphoma (Ki‐1 lymphoma). Our case is considered to be cutaneous Ki‐1 lymphoma preceded by Hodgkin's disease.
Effect of Zinc Supplementation on Epidermal Langerhans' Cells of Elderly Patients with Decubital Ulcers
Authors: Kohn Sarah , Kohn David , Schiller Dan 
Published: April 2015

AbstractIn the present study, Langerhans' cells (LCs) in the sacral epidermis, 8–10 cm from lesions of patients (mean age 71 years) with decubital ulcers, were compared ultrastructurally and morphometrically with those in the patients' own normal epidermis from the upper leg, before and after supplementation with 50 mg/day elementary zinc (in the form of a 220‐mg tablet of Avazinc, administered once daily) for four months. Zinc intake resulted in from 80% to full healing of the decubital ulcers in the patients studied. The percentages of LCs were low in both perilesional sacral epidermis (2.07 ± 0.71%) and in control leg epidermis (2.71 ± 1.38%) before zinc supplementation and also afterward (2.12 ± 0.16% and 2.59 ± 0.88%, respectively). LCs demonstrated a more dendritic morphology after zinc supplementation: 68.15 ± 9.28% and 77.0 ± 3.45% of sacral and of control leg epidermal LCs, respectively, had dendrites before, and 91.52 ± 3.43% and 84.15 ± 3.64% of sacral and of control leg epidermal LCs, respectively, had dendrites after zinc supplementation. The LC section area in the sacral epidermis near the lesion as well as in the control leg epidermis and the number of LC granules in LC sections were not affected by zinc supplementation. The higher percentage of LCs having dendrites in the epidermis of patients with decubital ulcers after zinc supplementation may indicate that these LCs are in a more motile state, which might affect the healing process of the lesions.
A Case of Pemphigus Vulgaris Successfully Treated with Single Filtration Plasmapheresis: A Correlation of Clinical Disease Activity with Serum Antibody Levels
Authors: Yano Chizuko , Ishiji Takaoki , Kamide Ryoichi , Niimura Michihito 
Published: April 2015

AbstractWe report a patient with pemphigus vulgaris (PV) successfully treated with single filtration plasmapheresis. A 40‐year‐old man with PV was started on therapy with prednisolone (PSL). Although the dosage of PSL was doubled, and both cyclosporin A (CyA) and pulse therapy were added, the disease was not controlled. After single filtration plasmapheresis began, most of the eroded lesions on the trunk reepithelialized. A switch to double filtration was followed by recurrence. Finally, additional treatments with single filtration plasmapheresis were required to obtain remission. To evaluate the efficacy of the treatment, circulating antibodies were measured by immunofluorescence (IIF) and enzyme‐linked immunosorbent assays (ELISAs) using recombinant desmoglein (Dsg) 3. IIF titer and the ELISA scores correlated with the clinical disease activity. It is suggested that ELISA was more sensitive than IIF.
Quinolone Drug Rash in a Patient with Infectious Mononucleosis
Authors: Paily Rejith 
Published: April 2015

AbstractInfectious mononucleosis and the associated ampicillin rash are well documented. The case of a patient with infectious mononucleosis who was treated with levofloxacin and developed a rash similar to the ampicillin rash is reviewed. The exact mechanism is not understood. With closer observation, physicians may be able to recognize more cases with similar phenomena.
Topical Anthralin for Psoriasis Vulgaris: Evaluation of 70 Japanese Patients
Authors: Yamamoto Toshiyuki , Matsuuchi Mizue , Irimajiri Junya , Otoyama Kazunobu , Nishioka Kiyoshi 
Published: April 2015

AbstractIn order to determine the usefulness of anthralin in the treatment of psoriasis, we evaluated the effectiveness of topical anthralin therapy in patients with psoriasis vulgaris in our hospital. Seventy patients with plaque‐type psoriasis (58 men and 12 women), aged 17–79 years‐old (mean; 47.6 years‐old), who were treated at the Department of Dermatology, Tokyo Medical and Dental University, between 1992 and 1999, were retrospectively evaluated. Mean psoriasis activity and severity index (PASI) score before therapy was 24.6. Patients were treated with 0.1–2.0% topical anthralin. Responses were determined by clinical examination. The mean PASI score decreased to 8.7 after three months. The most effective anthralin concentration was 0.4–0.5%. The overall response rate was 85.7%, complete remission was obtained in 21.4%, and partial remission in 64.3%. Ten patients (14.3%) were anthralin‐resistant. In all patients who entered complete remission, recurrence was noted within six months after stopping anthralin. Minor skin irritation and pigmentation occurred in most of the patients; however, no severe side effects were noted during the treatment. Our study indicated that anthralin is effective for chronic plaque‐type psoriasis.
An Open Trial of Oral Macrolide Treatment for Psoriasis Vulgaris
Authors: Komine Mayumi , Tamaki Kunihiko 
Published: April 2015

AbstractSeventeen patients were included in a clinical open trial of macrolides for treatment of psoriasis vulgaris. PASI scores, itch and ointment scores were used to evaluate their effectiveness. PASI scores dropped from 22.8 to 13.7; this was statistically significant. Itch reduced in 11 out of 13 patients, and the extent of itch reduced significantly by 54% on average. Ointment scores reduced from 44.9 to 34.4, which was also statistically significant. Macrolides are known not only as potent anti‐biotics, but also as immunomodulatory agents. These data suggest that macrolides could be used as one of the adjunctive therapies of psoriasis vulgaris, and this study is a first step toward the future evaluation of macrolides in a double blind trial.
Dermatitis Herpetiformis in a Japanese Patient with Anaplastic Large Cell Lymphoma
Authors: Amo Yasuyuki , Tanei Ryoji , Tanabe Kazumi , Katsuoka Kensei 
Published: April 2015

AbstractWe report a 73‐year‐old Japanese man with dermatitis herpetiformis which developed after diagnosis of anaplastic large cell lymphoma. The patient suffered fever, sweating, shivering, and multiple enlarged cervical lymph nodes. The diagnosis of anaplastic large cell lymphoma was confirmed by the histologic features of a biopsied cervical lymph node. The patient underwent combination chemotherapy. However, one month after the initial therapy, pruritic erythematous skin lesions with peripheral vesicles appeared on his buttocks. A skin biopsy showed subepidermal blister formation associated with polymorphonuclear and mononuclear cell infiltrates. Direct immunofluorescence examination of the area adjacent to the lesion showed granular deposits of IgA at the dermoepidermal junction. While it is well‐known that dermatitis herpetiformis can develop into lymphoma, there have been only a few reports of its appearance after a diagnosis of lymphoma. This case suggests that dermatitis herpetiformis may be induced by anaplastic large cell lymphoma.
Lichen Planus: A Clinical and Epidemiological Study
Authors: Bhattacharya Madhumita , Kaur Inderjeet , Kumar Bhushan 
Published: April 2015

AbstractClinical and epidemiological data from 232 patients with lichen planus is presented. Lichen planus constituted 0.38% of the total dermatology outpatients diagnosed. The patient ages ranged from 8 to 76 years, most being in the age range from 20 to 49 years. Duration of disease varied from 1 month to 7 years. Both sexes were equally affected. The majority of the patients (47.4%) had classical lesions followed by hypertrophic and actinic lichen planus next in frequency. Itching was the predominant symptom in 79.3%. Limbs were the most frequent initial site of onset (55.6%). Mucosal involvement along with cutaneous lesions were observed in 16.8% and genital involvement in only 5.2%. Nail changes were observed in 15.1% of patients. A history of recurrence of the disease was obtained from 10.3% of patients. Liver disease was found to be associated in 2.2% of patients. No malignant changes were observed in any of the lesions of lichen planus.
Changes in Plasma Serotonin Concentration and Acceleration Plethysmograms in Patients with Raynaud's Phenomenon after Long‐term Treatment with a 5‐HT2 Receptor Antagonist
Authors: Igarashi Masaru , Okuda Tomoki , Oh‐i Tsunao , Koga Michiyuki 
Published: April 2015

AbstractHigh blood serotonin concentrations have been reported in patients with Raynaud's phenomenon and a relationship has been suggested. Because of the difficulty in evaluating Raynaud's phenomenon objectively, a possible correlation between blood serotonin concentrations and clinical findings has not yet been evaluated. We measured plasma serotonin concentrations and acceleration plethysmograms (APG) before and one year after administration of a serotonin receptor antagonist. Twenty‐seven patients with either collagen disease or diseases associated with Raynaud's phenomenon were given a combined 5‐HT2 and serotonin receptor antagonist, sarpogrelate hydrochloride. Plasma serotonin concentrations were determined before and after administration and the APG d/a value was measured as an index of peripheral hemodynamics. These values were compared with the clinical symptoms of the patients. After one year of treatment, the subjective symptoms improved in 59.3% of patients who has Raynaud's phenomenon. The pre‐treatment plasma serotonin concentrations of the study patients were significantly higher than those of the normal controls, but became significantly decreased following 5‐HT2 administration. However, there was no clear‐cut relationship with the clinical symptoms. The pre‐treatment APG d/a value of the patients was significantly lower than that of the normal controls, although there was no significant difference after administration when analyzed as an entire group or in a subset of patients whose symptoms did not subjectively improve or worsened after one year of treatment. In the subset in whom the subjective symptoms improved, however, the value significantly increased following administration, suggesting an improvement in peripheral hemodynamics. These results suggest the possibility that APG can be used as an objective index of peripheral hemodynamics.