bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome wide identification and expression profile in epithelial cells exposed to TiO2 particles
Authors: Kim Tae‐Hoon , Shin Seung‐Woo , Park Jong‐Sook , Park Choon‐Sik 
Published: September 2013

ABSTRACTEnvironmental particles are believed to provoke airway inflammation in susceptible individuals by stimulating epithelial cells to release mediators that exacerbate lung diseases. Here, we sought to identify genes expressed throughout the genome by epithelial cells stimulated with TiO2 particles. A human bronchial epithelial cell line, BEAS‐2B, was stimulated with or without 40 µg TiO2 for 2 h. RNA was purified from cells and subjected to microarray analysis. Genes exhibiting more than a twofold change in RNA expression were selected. Candidate genes were then analyzed using bioinformatics tools, including pathway, ontology, and network analyses. ITGAV mRNA expression levels were measured in BEAS‐2B cells using real‐time polymerase chain reaction. Among 37,803 genes, 92 genes displayed more than a twofold change in mRNA levels according to the microarray analysis; 87 genes were upregulated while five genes were downregulated. The 92 genes were classified based on functional annotation using a protein information resource database search for biological processes and a pathway search using the KEGG pathway database. These genes are related to macromolecule biosynthesis, metabolic processes and, in particular, RNA metabolism. When genes with more than a threefold change were analyzed, KIF11, ITGAV, SEMA3C, IBTK, and DEK were selected as candidate genes induced by TiO2‐stimulated BEAS‐2B cells. To validate these results, BEAS‐2B cells stimulated with 40 µg TiO2 expressed threefold higher ITGAV mRNA levels compared to those without TiO2 particle stimulation. We conclude that KIF11, ITGAV, SEMA3C, IBTK, and DEK are candidate genes expressed by epithelial cells when stimulated with TiO2 particles. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 293–300, 2015.
Reintroduction medicine: Whooping cranes in Wisconsin
Authors: Keller Dominique L. , Hartup Barry K. 
Published: September 2013

AbstractThis paper presents veterinary management strategies and diagnostic findings in the reintroduction of the endangered whooping crane (Grus americana). Between 2005 and 2010, 63 (27 male, 36 female) hatchling whooping cranes were assigned to a reintroduction project involving autumn release of costume‐reared chicks in Wisconsin. Veterinary care included preventive measures and comprehensive pre‐release evaluations to improve fitness and reduce translocation of potential disease agents to native habitats. A total of 44 clinically normal birds were released (70% of assigned individuals). Cases of morbidity were classified according to primary body system affected. Musculoskeletal disorders were described in 57 birds (90%); five birds were removed from the project prior to release (8%), all for abnormalities that prevented normal function. Fourteen birds died or were euthanized prior to release (22%); pre‐release mortality was attributed to developmental abnormality, predation, trauma or infectious disease. Chronic respiratory aspergillosis, diagnosed in seven birds (11%), was the most common infectious disease of concern. Predation and trauma were primary causes of post‐release mortality; no evidence of infectious disease of captive origin was detected in the study population by the end of 2010. The assessment of data accumulated by this project helped to outline successful health management strategies, as well as identify and mitigate ongoing risks to captive whooping cranes that impede reintroduction efforts and achieving management goals for species recovery. Zoo Biol. 32:600–607, 2013. © 2013 Wiley Periodicals, Inc.
Projections of fractal percolations
Authors: RAMS MICHAŁ , SIMON KÁROLY 
Published: September 2013

AbstractIn this paper we study the radial and orthogonal projections and the distance sets of the random Cantor sets $E\subset { \mathbb{R} }^{2} $, which are called Mandelbrot percolation or percolation fractals. We prove that the following assertion holds almost surely: if the Hausdorff dimension of $E$ is greater than $1$ then the orthogonal projection to every line, the radial projection with every centre, and the distance set from every point contain intervals.
The Operator Space Projective Tensor Product: Embedding into the Second Dual and Ideal Structure
Authors: Jain Ranjana , Kumar Ajay 
Published: September 2013

AbstractWe prove that, for operator spaces V and W, the operator space V** ⊗hW** can be completely isometrically embedded into (V ⊗hW)**, ⊗h being the Haagerup tensor product. We also show that, for exact operator spaces V and W, a jointly completely bounded bilinear form on V × W can be extended uniquely to a separately w*-continuous jointly completely bounded bilinear form on V× W**. This paves the way to obtaining a canonical embedding of into with a continuous inverse, where is the operator space projective tensor product. Further, for C*-algebras A and B, we study the (closed) ideal structure of which, in particular, determines the lattice of closed ideals of completely.
Phenological and growth response of legume cover crops to shading
Authors: MAURO R. P. , SORTINO O. , DIPASQUALE M. , MAUROMICALE G. 
Published: September 2013

SUMMARYAnnual medics and clovers have distinct properties in terms of usage as cover crops in Mediterranean orchards, but little is known of their capacity to adapt to the level of shading encountered on an orchard floor. A 2-year field experiment was conducted in South–Eastern Sicily to investigate the effects of withholding 0·50 of sunlight on the phenology and growth pattern of four medic and five clover accessions, focusing on traits known to be important for cover cropping. Shading delayed both seedling emergence and the onset of flowering (by up to 5 and 9 days, respectively), while it extended both the growth period and the overall life-cycle duration (by up to 5 and 11 days, respectively). It also induced an increase in cover crop height (from 34 to 38 cm) and crop light use (from 0·60 to 0·94 g DW/m2/MJ), but a reduction in soil coverage, above-ground dry biomass, maximum growth rate and maximum relative growth rate (by up to 13, 18, 21 and 7%, respectively), so compromising the competitiveness of cover crops against weeds. The responses to shading varied between genotypes. Medicago polymorpha ecotype S. Rosalia, Medicago rugosa ecotype Piano Lauro and ecotype Zappulla were the strongest competitors against weeds, whereas Trifolium tomentosum ecotype Bucampello was interesting in terms of its biomass yield and crop light use. The performance was unstable over seasons, so any future attempt to improve the species’ performances under shade by breeding will need to focus on reseeding capacity.
Trophic importance of meiofauna to polychaetes in a seagrass (Zostera marina) bed as traced by stable isotopes
Authors: Ha Sun_Yong , Min Won-Ki , Kim Dong-Sung , Shin Kyung-Hoon 
Published: September 2013

Stable carbon and nitrogen isotope ratios of benthic invertebrates and their potential food sources, such as suspended particulate organic matter (POM), benthic microalgae, attached algae and seagrass, were identified in Dong-dae Bay during the winter. The carbon stable isotope ratios demonstrate that filter feeders, such as oysters (−19.5 ± 1.0‰), use benthic microalgae (−21.2 ± 0.2‰) as a major food, and polychaetes such as Glycera spp. (−14.0 ± 0.6 ‰) preferentially use meiofauna, such as nematodes (−14.0 ± 0.4‰) and copepods (−13.3 ± 1.0‰). These meiofauna may feed on mixed resources (including bacteria) with the isotope ratios between benthic microalgae (−21.2 ± 0.2‰) and seagrass (−9.3 ± 01.0‰). These findings are consistent with the trophic enrichment in the nitrogen isotope ratios (by 3–4‰) between consumers and food sources. Moreover, the results of the MixSIR model based on the observed isotope ratios suggest a large seagrass contribution to the food sources of benthic organisms such as meiofauna (~53.7–62.6%) and macrobenthos (~41.1–68%) through the food web. This model additionally suggests a relatively large contribution of benthic microalgae to the food sources of filter feeders (i.e. 26.4% for oysters).
Aortopulmonary window: a rare mechanism of inter-circulatory mixing and prepared left ventricle in transposition of the great arteries with intact ventricular septum
Authors: Gopalan Nair Rajesh , Kalathingathodika Sajeer , Bastian Cicy 
Published: September 2013

AbstractTransposition of the great arteries with intact ventricular septum and aortopulmonary window is an extremely rare anatomic combination associated with high morbidity and mortality. We report a case of a 3-month-old baby with d-transposition of the great arteries with intact ventricular septum and a large aortopulmonary window as a mechanism of inter-circulatory mixing.
Is the school food environment conducive to healthy eating in poorly resourced South African schools?
Authors: Faber Mieke , Laurie Sunette , Maduna Mamokhele , Magudulela Thokozile , Muehlhoff Ellen 
Published: September 2013

AbstractObjectiveTo assess the school food environment in terms of breakfast consumption, school meals, learners’ lunch box, school vending and classroom activities related to nutrition.DesignCross-sectional survey.SettingNinety purposively selected poorly resourced schools in South Africa.SubjectsQuestionnaires were completed by school principals (n 85), school feeding coordinators (n 77), food handlers (n 84), educators (n 687), randomly selected grade 5 to 7 learners (n 2547) and a convenience sample of parents (n 731). The school menu (n 75), meal served on the survey day, and foods at tuck shops and food vendors (n 74) were recorded.ResultsTwenty-two per cent of learners had not eaten breakfast; 24 % brought a lunch box, mostly with bread. Vegetables (61 %) were more often on the school menu than fruit (28 %) and were served in 41 % of schools on the survey day compared with 4 % serving fruit. Fifty-seven per cent of learners brought money to school. Parents advised learners to buy fruit (37 %) and healthy foods (23 %). Tuck shops and vendors sold mostly unhealthy foods. Lack of money/poverty (74 %) and high food prices (68 %) were major challenges for healthy eating. Most (83 %) educators showed interest in nutrition, but only 15 % had received training in nutrition. Eighty-one per cent of educators taught nutrition as part of school subjects.ConclusionsThe school food environment has large scope for improvement towards promoting healthy eating. This includes increasing access to vegetables and fruit, encouraging learners to carry a healthy lunch box, and regulating foods sold through tuck shops and food vendors.
Mother's education is the most important factor in socio-economic inequality of child stunting in Iran
Authors: Emamian Mohammad Hassan , Fateh Mansooreh , Gorgani Neman , Fotouhi Akbar 
Published: September 2013

AbstractObjectiveMalnutrition is one of the most important health problems, especially in developing countries. The present study aimed to describe the socio-economic inequality in stunting and its determinants in Iran for the first time.DesignCross-sectional, population-based survey, carried out in 2009. Using randomized cluster sampling, weight and height of children were measured and anthropometric indices were calculated based on child growth standards given by the WHO. Socio-economic status of families was determined using principal component analysis on household assets and social specifications of families. The concentration index was used to calculate socio-economic inequality in stunting and its determinants were measured by decomposition of this index. Factors affecting the gap between socio-economic groups were recognized by using the Oaxaca–Blinder decomposition method.SettingShahroud District in north-eastern Iran.SubjectsChildren (n 1395) aged <6 years.ResultsThe concentration index for socio-economic inequality in stunting was −0·1913. Mother's education contributed 70 % in decomposition of this index. Mean height-for-age Z-score was −0·544 and −0·335 for low and high socio-economic groups, respectively. Mother's education was the factor contributing most to the gap between these two groups.ConclusionsThere was a significant socio-economic inequality in the studied children. If mother's education is distributed equally in all the different groups of Iranian society, one can expect to eliminate 70 % of the socio-economic inequalities. Even in high socio-economic groups, the mean height-for-age Z-score was lower than the international standards. These issues emphasize the necessity of applying new interventions especially for the improvement of maternal education.
Fourteen-year trends in sodium content of menu offerings at eight leading fast-food restaurants in the USA
Authors: Rudelt Amanda , French Simone , Harnack Lisa 
Published: September 2013

AbstractObjectiveTo examine changes in the Na content of lunch/dinner menu offerings at eight of the leading fast-food restaurants in the USA between 1997/1998 and 2009/2010.DesignMenu offerings and nutrient composition information for the menu items were obtained from archival versions of the University of Minnesota Nutrition Coordinating Center (NCC) Food and Nutrient Database. Nutrient composition information for lunch/dinner menu items sold by the fast-food restaurants included in the present study was updated in the database biannually. Menus were analysed for changes in mean Na content of all menu offerings (except beverages) and specific categories of menu items among all restaurants and for each individual restaurant.SettingUSA.SubjectsLunch/dinner food menu of eight leading US fast-food restaurants.ResultsBetween 1997/1998 and 2009/2010 the mean Na content of menu offerings across the eight restaurants increased by 23·4 %. Examining specific food categories, mean Na content of entrées by increased 17·2 % and that of condiments increased by 26·1 %. Only side dishes showed a decrease of 6·6 %. None of the restaurants examined had a decrease in Na across the lunch/dinner menu offerings over the 14 years examined.ConclusionsResults suggest that over the time period studied there has been no meaningful reduction in the Na content of lunch/dinner menu offerings at the leading fast-food restaurants examined in the present study.
The Baltic Sea Diet Score: a tool for assessing healthy eating in Nordic countries
Authors: Kanerva Noora , Kaartinen Niina E , Schwab Ursula , Lahti-Koski Marjaana , Männistö Satu 
Published: September 2013

AbstractObjectiveThe health-related effects of the Nordic diet remain mostly unidentified. We created a Baltic Sea Diet Score (BSDS) for epidemiological research to indicate adherence to a healthy Nordic diet. We examined associations between the score and nutrient intakes that are considered important in promoting public health. We also examined the performance of the BSDS under two different cut-off strategies.DesignThe cross-sectional study included two phases of the National FINRISK 2007 Study. Diet was assessed using a validated FFQ. Food and nutrient intakes were calculated using in-house software. Nine components were selected for the score. Each component was scored according to both sex-specific consumption quartiles (BSDS-Q) and medians (BSDS-M), and summed to give the final score values.SettingA large representative sample of the Finnish population.SubjectsMen (n 2217) and women (n 2493) aged 25 to 74 years.ResultsIn the age- and energy-adjusted model, adherence to the diet was associated with a higher intake of carbohydrates (E%), and lower intakes of SFA (E%) and alcohol (E%, where E% is percentage of total energy intake; P < 0·01). Furthermore, the intakes of fibre, Fe, vitamins A, C and D, and folate were higher among participants who adhered to the diet (P < 0·05). After further adjustments, the results remained significant (P < 0·05) and did not differ remarkably between BSDS-Q and BSDS-M.ConclusionsThe BSDS can be used as a measure of a healthy Nordic diet to assess diet–health relationships in public health surveys in Nordic countries.
Solar-Blind Photodetectors for Harsh Electronics
Authors: Tsai Dung-Sheng , Lien Wei-Cheng , Lien Der-Hsien , Chen Kuan-Ming , Tsai Meng-Lin , Senesky Debbie G. , Yu Yueh-Chung , Pisano Albert P. , He Jr-Hau 
Published: September 2013

AbstractWe demonstrate solar-blind photodetectors (PDs) by employing AlN thin films on Si(100) substrates with excellent temperature tolerance and radiation hardness. Even at a bias higher than 200 V the AlN PDs on Si show a dark current as low as ~ 1 nA. The working temperature is up to 300°C and the radiation tolerance is up to 1013 cm−2 of 2-MeV proton fluences for AlN metal-semiconductor-metal (MSM) PDs. Moreover, the AlN PDs show a photoresponse time as fast as ~ 110 ms (the rise time) and ~ 80 ms (the fall time) at 5 V bias. The results demonstrate that AlN MSM PDs hold high potential in next-generation deep ultraviolet PDs for use in harsh environments.
Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors
Authors: Douglas Ross G. , Sharma Rajni K. , Masuyer Geoffrey , Lubbe Lizelle , Zamora Ismael , Acharya K. Ravi , Chibale Kelly , Sturrock Edward D. 
Published: September 2013

ACE (angiotensin-1-converting enzyme) is a zinc metallopeptidase that plays a prominent role in blood pressure regulation and electrolyte homeostasis. ACE consists of two homologous domains that despite similarities of sequence and topology display differences in substrate processing and inhibitor binding. The design of inhibitors that selectively inhibit the N-domain (N-selective) could be useful in treating conditions of tissue injury and fibrosis due to build-up of N-domain-specific substrate Ac-SDKP (N-acetyl-Ser–Asp–Lys–Pro). Using a receptor-based SHOP (scaffold hopping) approach with N-selective inhibitor RXP407, a shortlist of scaffolds that consisted of modified RXP407 backbones with novel chemotypes was generated. These scaffolds were selected on the basis of enhanced predicted interaction energies with N-domain residues that differed from their C-domain counterparts. One scaffold was synthesized and inhibitory binding tested using a fluorogenic ACE assay. A molecule incorporating a tetrazole moiety in the P2 position (compound 33RE) displayed potent inhibition (Ki=11.21±0.74 nM) and was 927-fold more selective for the N-domain than the C-domain. A crystal structure of compound 33RE in complex with the N-domain revealed its mode of binding through aromatic stacking with His388 and a direct hydrogen bond with the hydroxy group of the N-domain specific Tyr369. This work further elucidates the molecular basis for N-domainselective inhibition and assists in the design of novel N-selective ACE inhibitors that could be employed in treatment of fibrosis disorders.
Quantitative Assessment of Interutterance Stability: Application to Dysarthria
Authors: Cummins Fred , Lowit Anja , van Brenk Frits 
Published: September 2013

Purpose
Following recent attempts to quantify articulatory impairment in speech, the present study evaluates the usefulness of a novel measure of motor stability to characterize dysarthria.

Method
The study included 8 speakers with ataxic dysarthria (AD), 16 speakers with hypokinetic dysarthria (HD) as a result of Parkinson's disease, and 24 unimpaired control participants. Each participant performed a series of sentence repetitions under habitual, fast, and slow speaking rate conditions. An algorithm to measure utterance-to-utterance spectro-temporal variation (UUV; Cummins, 2009) was used. Speech rate and intelligibility were also measured.

Results
UUV scores were significantly correlated with perceptually based intelligibility scores. There were significant differences in UUV between control speakers and the AD but not the HD groups, presumably because of differences in intelligibility in the samples used and not because of differences in pathology. Habitual speaking rate did not correlate with UUV scores. All speaker groups had greater UUV levels in the slow conditions compared with habitual and fast speaking rates.

Conclusions
UUV results were consistent with those of other variability indices and thus appear to capture motor control issues in a similar way. The results suggest that the UUV could be developed into an easy-to-use clinical tool that could function as a valid and reliable assessment and outcome measure.

Supplemental Material

https://doi.org/10.23641/asha.6170402
Tongue Motion Patterns in Post-Glossectomy and Typical Speakers: A Principal Components Analysis
Authors: Stone Maureen , Langguth Julie M. , Woo Jonghye , Chen Hegang , Prince Jerry L. 
Published: September 2013

PurposeIn this study, the authors examined changes in tongue motion caused by glossectomy surgery. A speech task that involved subtle changes in tongue-tip positioning (the motion from /i/ to /s/) was measured. The hypothesis was that patients would have limited motion on the tumor (resected) side and would compensate with greater motion on the nontumor side in order to elevate the tongue tip and blade for /s/.MethodVelocity fields were extracted from tagged magnetic resonance images in the left, middle, and right tongue of 3 patients and 10 controls. Principal components (PCs) analysis quantified motion differences and distinguished between the subject groups.ResultsPCs 1 and 2 represented variance in (a) size and independence of the tongue tip, and (b) direction of motion of the tip, body, or both. Patients and controls were correctly separated by a small number of PCs.ConclusionsMotion of the tumor slice was different between patients and controls, but the nontumor side of the patients' tongues did not show excessive or adaptive motion. Both groups contained apical and laminal /s/ users, and 1 patient created apical /s/ in a highly unusual manner.
Influence of optical amplifier on inter‐satellite microwave photonics links employing a low‐biased Mach‐Zehnder modulator
Authors: Zhu Zihang , Zhao Shanghong , Yao Zhoushi , Li Yongjun , Jiang Wei , Wang Xiang , Zhao Guhao 
Published: September 2013

An exact analytical expression of signal‐to‐noise ratio (SNR) for inter‐satellite microwave photonics links using a low‐biased Mach‐Zehnder modulator, and with both an optical booster amplifier and a preamplifier, is derived with the method of Bessel expansion and Graf's addition theorem. It is observed that the most limitative noise is changed from the thermal noise to the signal‐amplifier spontaneous emission beating noise that arises from the optical preamplifier, and the signal power is seen to increase more compared with the power of noise because of optical preamplifier. Thus, the SNR of system configurations with both an optical booster amplifier and an optical preamplifier can be improved compared with the SNR of system configurations with only an optical booster amplifier. For the preamplifier gain of 20 dB and noise figure of 3 dB, an increase of about 19.7 dB in optimum SNR is accessible. In addition, the effect of optical booster amplifier and preamplifier parameters on the optimum DC bias phase shift and SNR is also investigated.
A simulator for spatially extended kappa models
Authors: Sorokina Oksana , Sorokin Anatoly , Douglas Armstrong J. , Danos Vincent 
Published: September 2013

Abstract
Summary: Spatial Kappa is a simulator of models written in a variant of the rule-based stochastic modelling language Kappa, with spatial extensions.
Availability: The spatial kappa simulator is an open-source project licensed under the LGPLv3, with Java source, binaries and manual available at http://github.com/lptolik/SpatialKappa.
Contact: oksana.sorokina@ed.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.