bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalpol reduced LPS induced BV2 immunoreactivity through NF-κB/NLRP3 pathways: an in Vitro and in silico study
Authors: She Yong , Shao Chong-yu , Liu Yuan-feng , Huang Ying , Yang Jiehong , Wan Hai-tong 
Published: June 2024

Background: Ischemic Stroke (IS) stands as one of the primary cerebrovascular diseases profoundly linked with inflammation. In the context of neuroinflammation, an excessive activation of microglia has been observed. Consequently, regulating microglial activation emerges as a vital target for neuroinflammation treatment. Catalpol (CAT), a natural compound known for its anti-inflammatory properties, holds promise in this regard. However, its potential to modulate neuroinflammatory responses in the brain, especially on microglial cells, requires comprehensive exploration.Methods: In our study, we investigated into the potential anti-inflammatory effects of catalpol using lipopolysaccharide (LPS)-stimulated BV2 microglial cells as an experimental model. The production of nitric oxide (NO) by LPS-activated BV2 cells was quantified using the Griess reaction. Immunofluorescence was employed to measure glial cell activation markers. RT-qPCR was utilized to assess mRNA levels of various inflammatory markers. Western blot analysis examined protein expression in LPS-activated BV2 cells. NF-κB nuclear localization was detected by immunofluorescent staining. Additionally, molecular docking and molecular dynamics simulations (MDs) were conducted to explore the binding affinity of catalpol with key targets.Results: Catalpol effectively suppressed the production of nitric oxide (NO) induced by LPS and reduced the expression of microglial cell activation markers, including Iba-1. Furthermore, we observed that catalpol downregulated the mRNA expression of proinflammatory cytokines such as IL-6, TNF-α, and IL-1β, as well as key molecules involved in the NLRP3 inflammasome and NF-κB pathway, including NLRP3, NF-κB, caspase-1, and ASC. Our mechanistic investigations shed light on how catalpol operates against neuroinflammation. It was evident that catalpol significantly inhibited the phosphorylation of NF-κB and NLRP3 inflammasome activation, both of which serve as upstream regulators of the inflammatory cascade. Molecular docking and MDs showed strong binding interactions between catalpol and key targets such as NF-κB, NLRP3, and IL-1β.Conclusion: Our findings support the idea that catalpol holds the potential to alleviate neuroinflammation, and it is achieved by inhibiting the activation of NLRP3 inflammasome and NF-κB, ultimately leading to the downregulation of pro-inflammatory cytokines. Catalpol emerges as a promising candidate for the treatment of neuroinflammatory conditions.
Digitalization and job stress: exploring the mediating roles of job and personal aversion risk with gender as a moderator
Authors: Han Shibo 
Published: June 2024

BackgroundThis time-lagged study delves into the impact of digitalization on job stress. Digitalization is defined as the incorporation of digital technologies into various aspects of work life, fundamentally transforming processes, interactions, and decision-making.AimThe present research focuses on the mediating roles of job-related risk and personal risk, and the moderating effect of gender. We hypothesized that employees’ aversion to risks, both in their professional and personal facets, mediates the relationship between the rapid digitalization of their work environment and the resultant job stress. Regarding gender as a moderator, recent research suggests that gender can influence the experience of workplace stress, with women often experiencing higher levels of stress than men in certain situations. This indicates that gender might also moderate the relationship between digital living, risk perception, and job-related stress. This approach allows for an examination of the ways in which digital technology adoption influences workplace stress, considering the temporally spaced data.MethodsConducted over three waves of data collection among 795 Chinese employees, the research utilizes Hayes’s Model 8, adept at revealing the dynamics of digitalization’s influence in the workplace and its effects on individual well-being.ResultsThe study corroborates Hypothesis 1 by establishing a significant, albeit less pronounced, relationship between digital living and job stress. The findings also support Hypothesis 2 by demonstrating that both job risk and personal risk mediate this relationship. The study’s results also validate Hypothesis 3, indicating that gender moderates the relationship between digital living, job risk, personal risk, and job stress. Finally, the significant interaction effects found in the study, particularly the stronger conditional negative effect of digital living on perceptions of job and personal risks for males, despite the absence of statistical significance failed to support Hypothesis 4.ImplicationsThis study sheds light on the dynamics of job stress in the context of a digitalizing work environment. The results have important implications for designing workplace strategies and interventions that are sensitive to risk perceptions and gender differences in the digital era.
The effect of group art therapy on the stress coping ability of Chinese international students in South Korea: using the person-in-the-rain test
Authors: Yin Yue , Ko Kyung Soon 
Published: June 2024

IntroductionThis study aimed to determine the effectiveness of group therapy on the stress coping skills of Chinese students in Korea using a pre-test post-test control group design.MethodsThirty participants were randomly placed into an experimental group (EG; n = 15) and a control group (CG; n = 15). The EG completed eight 120-min sessions of group art therapy. The Person-in-the-Rain (PITR) drawing test was conducted with both groups before and after the EG completed art therapy.ResultsThe test revealed that EG members demonstrated lower stress and significantly higher stress resources and coping abilities than the CG members after the intervention. The group art therapy program improved the EG participants’ ability to deal with stress.DiscussionThis study’s findings may offer insights useful for determining how best to provide psychological and emotional support to international students who have left their home countries and are continuing their academic journeys abroad.
Adolescent mental health interventions: a narrative review of the positive effects of physical activity and implementation strategies
Authors: Li Zhaojin , Li Jie , Kong Jianda , Li Zhilin , Wang Rui , Jiang Fugao 
Published: June 2024

IntroductionThe psychological well-being of adolescents is a global concern due to increasing societal pressures and mental health issues. Physical activity is known to enhance physical health and has potential benefits for mental health, including reducing symptoms of anxiety and depression, boosting self-esteem, and improving social skills. This narrative review explores how physical activity can serve as an intervention to help adolescents manage psychological stress and prevent mental health issues.MethodsAn extensive literature search was conducted using databases such as PubMed, PsycINFO, Web of Science, and Scopus. Keywords included “adolescent mental health,” “physical activity,” “psychological intervention,” “types of exercise,” “anxiety,” “depression,” “self-esteem,” “social skills,” and “emotional regulation.” Studies were included based on relevance, peer-reviewed status, and involvement of adolescent populations. Data were extracted and analyzed qualitatively, focusing on the psychological impacts of different types of physical activity. Sixty one articles were eventually included.Results and conclusionThe review identified multiple studies highlighting the positive effects of various physical activities on adolescent mental health. Aerobic exercises were found to improve mood and cognitive function, strength training reduced depressive symptoms and increased self-efficacy, team sports enhanced social skills and a sense of community, and mind–body practices like yoga and tai chi improved stress management and emotional regulation. The findings suggest that physical activity can play a significant role in promoting adolescent mental health. Implementation strategies in school and community settings, including integrating physical activity into school curricula, offering diverse activity options, training professional instructors, encouraging family and community involvement, and regular monitoring and evaluation, are recommended. Future research should address limitations such as sample diversity and long-term effects. This narrative review underscores the importance of physical activity in enhancing adolescent mental health. Effective implementation strategies and multi-sector collaboration are essential for maximizing the benefits of physical activity interventions.
Transcutaneous auricular vagus nerve stimulation improves social deficits through the inhibition of IL-17a signaling in a mouse model of autism
Authors: Zhang Wenjing , Mou Zhiwei , Zhong Qi , Liu Xiaocao , Yan Lan , Gou Lei , Chen Zhuoming , So Kwok-Fai , Zhang Li 
Published: June 2024

BackgroundMaternal exposure to inflammation is one of the causes of autism spectrum disorder (ASD). Electrical stimulation of the vagus nerve exerts a neuroprotective effect via its anti-inflammatory action. We thus investigated whether transcutaneous auricular vagus nerve stimulation (taVNS) can enhance social abilities in a mouse model of ASD induced by maternal immune activation (MIA).MethodsASD mouse model were constructed by intraperitoneal injection of polyinosinic:polycytidylic acid (poly (I:C)). TaVNS with different parameters were tested in ASD mouse model and in C57BL/6 mice, then various behavioral tests and biochemical analyses related to autism were conducted. ASD model mice were injected with an interleukin (IL)-17a antibody into the brain, followed by behavioral testing and biochemical analyses.ResultsTaVNS reduced anxiety, improved social function, decreased the number of microglia, and inhibited M1 polarization of microglia. Additionally, taVNS attenuated the expression of the IL-17a protein in the prefrontal cortex and blood of ASD model mice. To examine the possible involvement of IL-17a in taVNS-induced neuroprotection, we injected an IL-17a antibody into the prefrontal cortex of ASD model mice and found that neutralizing IL-17a decreased the number of microglia and inhibited M1 polarization. Furthermore, neutralizing IL-17a improved social function in autism model mice.ConclusionOur study revealed that reduced neuroinflammation is an important mechanism of taVNS-mediated social improvement and neuroprotection against autism. This effect of taVNS could be attributed to the inhibition of the IL-17a pathway.
Participation as a means-implications for intervention reasoning
Authors: Granlund Mats , Imms Christine 
Published: June 2024

IntroductionThe increased focus among researchers and professionals on participation as an explicit intervention outcome has prompted a paradigm shift in both thought and practice. However, much research centers on altering participation outcomes in specific life situations and stages. This discussion paper considers “participation as a means” in pediatric rehabilitation and special education interventions, emphasizing its role in achieving lasting outcomes.MethodThis paper uses a Venn diagram approach to consider relations between three core concepts—participation, intervention, and outcomes—and their intersection. The paper's central theme revolves around the intersection of these concepts, wherein participation serves as a means to achieve enduring participation outcomes within the realms of rehabilitation and special education. The discussion is supported by contemporary empirical work and from literature identified in two recent scoping reviews focusing on the intervention process.ResultsAchieving enduring participation outcomes through participation in the intervention process necessitates creating a learning experience, with children and families actively participating in every step: identifying participation issues, seeking explanations, prioritizing intervention goals, selecting methods, implementing interventions, and evaluating the process and outcomes.DiscussionThis structured approach supports professionals and researchers to foster the skills and capacity required for lasting participation outcomes for children with impairments.
Yeast peptides alleviate lipopolysaccharide-induced intestinal barrier damage in rabbits involving Toll-like receptor signaling pathway modulation and gut microbiota regulation
Authors: Fan Jiaqi , Li Chong , Han Wenxiao , Wu Fengyang , Fan Huimin , Fan Dongfeng , Liu Yajuan , Gu Zilin , Wang Yuanyuan , Chen Saijuan , Chen Baojiang 
Published: June 2024

IntroductionYeast peptides have garnered attention as valuable nutritional modifiers due to their potential health benefits. However, the precise mechanisms underlying their effects remain elusive. This study aims to explore the potential of yeast peptides, when added to diets, to mitigate lipopolysaccharide (LPS)-induced intestinal damage and microbiota alterations in rabbits.MethodsA total of 160 35-day-old Hyla line rabbits (0.96 ± 0.06 kg) were randomly assigned to 4 groups. These groups constituted a 2 × 2 factorial arrangement: basal diet (CON), 100 mg/kg yeast peptide diet (YP), LPS challenge + basal diet (LPS), LPS challenge +100 mg/kg yeast peptide diet (L-YP). The experiment spanned 35 days, encompassing a 7-day pre-feeding period and a 28-day formal trial.ResultsThe results indicated that yeast peptides mitigated the intestinal barrier damage induced by LPS, as evidenced by a significant reduction in serum Diamine oxidase and D-lactic acid levels in rabbits in the L-YP group compared to the LPS group (p &lt; 0.05). Furthermore, in the jejunum, the L-YP group exhibited a significantly higher villus height compared to the LPS group (p &lt; 0.05). In comparison to the LPS group, the L-YP rabbits significantly upregulated the expression of Claudin-1, Occludin-1 and ZO-1 in the jejunum (p &lt; 0.05). Compared with the CON group, the YP group significantly reduced the levels of rabbit jejunal inflammatory cytokines (TNF-α, IL-1β and IL-6) and decreased the relative mRNA expression of jejunal signaling pathway-associated inflammatory factors such as TLR4, MyD88, NF-κB and IL-1β (p &lt; 0.05). Additionally, notable changes in the hindgut also included the concentration of short-chain fatty acids (SCFA) of the YP group was significantly higher than that of the CON group (p &lt; 0.05). 16S RNA sequencing revealed a substantial impact of yeast peptides on the composition of the cecal microbiota. Correlation analyses indicated potential associations of specific gut microbiota with jejunal inflammatory factors, tight junction proteins, and SCFA.ConclusionIn conclusion, yeast peptides have shown promise in mitigating LPS-induced intestinal barrier damage in rabbits through their anti-inflammatory effects, modulation of the gut microbiota, and maintenance of intestinal tight junctions.
Multi-Objective Optimization Study on the Coupling Mechanism of Underwater Wireless Power Transfer Systems
Authors: Hu Qiong , Zheng Meiling , Li Zhenfu , Qin Yu , Huang Junqiang , Ou Yujia 
Published: June 2024

Magnetically coupled resonant wireless power transfer (MCR-WPT) technology offers longer effective transmission distances and higher efficiency compared to traditional charging methods, making it better suited to the prolonged and efficient operation of autonomous underwater vehicles. This paper first establishes a traditional mathematical model and then refines it while analyzing the variations in the self-inductance and mutual inductance of underwater coils. To further enhance the system’s performance, a multi-objective optimization of the coupling mechanism is conducted. An orthogonal experiment is employed to determine the effects of various influencing factors on the coils’ self-inductance and mutual inductance. Subsequently, an RBF neural network is used to create a regression prediction model based on the results of the orthogonal experiment. The NSGA-II algorithm is then applied for the multi-objective optimization of the coupling mechanism, resulting in a Pareto front solution set. The optimized efficiency is 93.35%, representing an approximately 6% improvement over the original system, with the power density increasing from 1.267×106 W/m3 before optimization to 4.782×106 W/m3 after optimization. Significant enhancement in system performance is achieved.
Perancangan Mebel Fasilitas Belajar dan Bermain Anak-Anak Pra-Sekolah dengan Metoda Partisipatoris
Authors: Dharmawan Cherry Cherry 
Published: June 2024

Artikel ini membahas proses perancangan fasilitas belajar dan bermain untuk anak-anak pra sekolah dengan metode partisipatori di Taman Kanak-Kanak Al Qur’an (Tkq) Ikhlasunniyah, Bandung. Fasilitas belajar dan bermain berupa sebuah meja belajar dan bermain dalam satu fasilitas untuk ana-anak pra-sekolah. Permasalahan dari penelitian ini ialah Bagaimana desain fasilitas untuk belajar dan bermain yang murah. Selain itu juga permasalahan lainnya adalah bagaimana bahan-bahan tersebut harus mempunyai tingkat keamanan dan kesehatan pada . Penelitian ini menggunakan metode partsipatori, bepusat pada pengguna ( Human center design ), yang merupakan sebuah metoda dari pemikiran design thinking. Setiap tahapan harus melibatkan pengguna / user.Hasil akhir dari penilitian ini adalah prototipe sebuah meja belajar dan bermain dengan memanfaatan bahan-bahan bekas dari sisa proyek interior di workshop- workshop di Bandung yang merupakan terjemahan dari berbagai aktivitas yang dapat melatih motorik halus dari anak-anak pra-sekolah.
Identification and Mapping of Fintech Clustering Using a Qualitative-dominant Mixed Method
Authors: Karim Saima , Cunningham Isobel , Bradley McCauley Laura 
Published: June 2024

This research delves into the complex landscape of the fintech ecosystem, specifically focusing on the Northwest City region of Ireland, employing a mixed-method approach. The study focused on the methodology used to identify and map the fintech clusters. Different methodologies have been used to map and identify clustering due to its evolving nature. In our case, due to the lack of fintech companies' records on publicly available databases, and fintech being an emerging phenomenon, our methodology relied on a combination of approaches like desk research, stakeholder engagement, geospatial analysis, and in-depth interviews which fall under the qualitative-dominant mixed method approach. Despite a diverse range of methodologies being used to identify clusters, some known studies have used mixed methods. This research aims to provide guidelines for identifying clusters by developing a database of the companies in the fintech sector and its validation in an evolving field like Fintech. It also highlights the importance of the use of geospatial analysis in clustering by mapping the fintech companies, however at the same time questions the simple agglomeration of the firms in the region. It’s not only the physical proximity that develops the clusters but the local linkages, collaborations, and networks that play a pivotal role in reaping the benefits of clusters. The detailed interviews with the fintech companies in the region and their relationship with different components of the fintech ecosystem using the triple helix model highlighted the strengths and weaknesses of the fintech ecosystem in the region. The application of mixed methods in this research highlights the value gained in exploring fintech clustering and ecosystems. This study further enhances our understanding of the emerging phenomenon of fintech clusters and ecosystems in cluster-based economies, specifically how a combination of approaches could be used to map and identify fintech clusters. It also furthers the boundaries of knowledge in business and management methodological literature by introducing a comprehensive qualitative-dominant mixed method approach with a consolidating knowledge base on methodological approaches to clustering.
Natural Experiments and Causation in Strategy Research
Authors: Erickson Scott , Rothberg Helen 
Published: June 2024

Research to inform organizational strategy decisions studies the impact of specific managerial decisions on performance. While links from decisions to outcomes can be convincingly identified in individual, specific circumstances, trying to do the same with a larger set of decisions and outcomes can be problematic. In a situation with a substantive sample, relying on standard metrics such as financial statements, the link to particular outcomes can be difficult to establish. Especially when trying to choose metrics not already correlated in some way.

Our research is generally in the field of knowledge management (KM). The discipline has an extensive history of attempts to link better management of knowledge and other intangibles to performance outcomes. While the performance outcomes are fairly straightforward (financial success such as profitability or return on investment, innovation success, etc.), the metric for knowledge management is harder to pin down. The literature shows dozens of approaches. Some are for single firms or a small sample, but even if focusing only on metrics for a larger sample of firms, disagreement exists.

But even when a KM metric is chosen for a larger sample, there is often a direct tie between input and output measures, making correlation difficult to establish, let alone causation. If profitability is part of both the input and output measures, of course they are correlated. The most advanced statistical techniques don’t establish anything more than what the researcher should already know from a cursory look at the logic of the study and the specifics of the variables. As a result, whether KM actually results in better organizational performance is still an open and much debated question in the field.

One research approach that can get around this issue is the natural experiment. Pioneered by Nobel winner David Card and others, the natural experiment uses two measurements with a clear, consequential event separating the two—minimizing the impact of samples that might otherwise be connected contemporaneously. The event, such as a change in law, provides a change in circumstances delinking the measures. Whether structured as a pre/post experiment (measuring before or after the intervening event) or control/experimental group experiment (one group exposed to the event, the other not), the outcome can provide convincing results and can even suggest causation.

This paper will cover our work with natural experiments in relation to KM and performance outcomes for merger and acquisition (M&A) activity. Can KM metrics before an M&A event predict the success of the event? Success can be defined by the change in financial performance after the event takes place.