bluuebunny/crossref_metadata_2025_split huggingface dataset:
How national context moderates the impact of family-supportive supervisory behavior on job performance and turnover intentions
Authors: Las Heras Mireia , Trefalt Spela , Escribano Pablo Ignacio 
Published: June 2015

Purpose– The purpose of this study was to examine how national context moderates the impact of family supportive supervisory behavior (FSSB) on employee’s job performance and turnover intentions. The authors consider direct and indirect (through work–family positive spillover) effects of FSSB. Our model is based on conservation of resources (COR) theory and boundary theory. The authors conceptualize national context as contributing resources to or threatening with loss of resources for individuals. To test the model, the authors use data from three Latin American countries – Brazil, Chile and Ecuador.Design/methodology/approach– This is a cross-sectional study based on a survey of almost 988 individuals. The authors first test the direct and indirect effects (via bi-directional positive spillover) of FSBB on performance and turnover intentions without considering the moderating effects of national context (mediation analysis). Then, the authors test the effect of national context in our baseline model by conducting a moderation analysis of direct and indirect effects. The authors use seemingly unrelated regressions and account for control variables and country-level effects.Findings– The results confirm that national context affects the relationships between FSSB and outcomes. As unemployment rises, the effect of FSSB on turnover intentions is stronger and the effect of FSSB on performance, via bi-directional work–family positive spillover, is stronger. When social expenditures increase, the relationship between FSSB and performance via work–family positive spillover becomes weaker. In addition, the authors find some unexpected results.Originality/value– The authors advance the understanding of how national context affects the impact of FSSB on outcomes, specifically in Latin America. The authors conceptualize national context as providing or threatening individuals’ resources, using publicly available data on unemployment and social expenditures.
Mode‐converted volcanogenic massive sulphide ore lens reflections in vertical seismic profiles from Flin Flon, Manitoba, Canada
Authors: Melanson D.M. , White D.J. , Samson C. , Bellefleur G. , Schetselaar E. , Schmitt D.R. 
Published: June 2015

ABSTRACTIn October 2006, three‐component zero‐offset vertical seismic profile data were acquired from a deviated well in the Flin Flon mining camp in Manitoba, Canada, using a dynamite source. These vertical seismic profile data were processed to reveal reflections originating from the 85.5 Mt Flin Flon‐Callinan‐777 volcanogenic massive sulphide ore system. From drill records, mine plans, surficial maps, and seismic data, 3D voxel models of the local geology and known ore zones were built, which were then used in 3D finite‐difference modelled simulations of the vertical seismic profile surveys. The number of geological units partitioning the model was incrementally increased to study the effects of the massive sulphide ore and the major rock units on the seismic response. The simulations and field data were jointly visualized, and reflections originating at some of the known ore zones were identified. These reflections were observed in each of the three components in both the real field and the forward modelled data and indicate a strong mode‐converted component of the reflected wavefield.
Earthquake detection probability within a seismically quiet area: application to the Bruchsal geothermal field
Authors: Gaucher Emmanuel 
Published: June 2015

ABSTRACTIn applications such as oil and gas production, deep geothermal energy production, underground storage, and mining, it is common practice to implement local seismic networks to monitor and to mitigate induced seismicity. For this purpose, it is crucial to determine the capability of the network to detect a seismic event of predefined magnitude in the target area. The determination of the magnitude of completeness of a network is particularly required to properly interpret seismic monitoring results. We propose a method to compute the detection probability for existing local seismic networks, which (i) strictly follows the applied detection sequence; (ii) estimates the detection capability where seismicity has not yet occurred; and (iii) delivers the results in terms of probabilities. The procedure includes a calibration of a local magnitude scale using regional earthquakes recorded by the network and located outside the monitored area. It involves pre‐processing of the seismograms recorded at each station as performed during the triggering sequence, which is assumed based on amplitude thresholds. Then, the calibrated magnitude–distance–amplitude relations are extrapolated at short distances and combined to reproduce the network detection sequence. This generates a probability to detect a seismic event of a given magnitude at a specified location. This observation‐based approach is an alternative to a fully theoretical detection capability modelling and includes field conditions. Seismic wave attenuation by geometrical spreading and intrinsic attenuation, site effect, and instrumental responses are partly accounted for by the calibration. We apply this procedure on the seismic network deployed in the Bruchsal geothermal field (Germany). Although the system was in good working order, no induced seismicity was identified in the area between June 2010, when monitoring started, and November 2012. The recording of distant seismicity during this time period, however, allowed the application of the proposed procedure. According to the applied network detection parameters, the results indicate that the absence of seismicity can be interpreted as a 95% probability that no seismic event with ML ≥ 0.7 occurred below the network at 2.4‐km depth, i.e., in the geothermal reservoir.
Staff perceptions of palliative care in a public Australian, metropolitan emergency department
Authors: Russ Andrew , Mountain David , Rogers Ian R , Shearer Freya , Monterosso Leanne , Ross‐Adjie Gail , Rogers Jeremy R 
Published: June 2015

AbstractObjectiveThe primary aim was to investigate staff experiences and attitudes towards palliative care provision in a public metropolitan ED.MethodsUsing a previously validated survey tool, data were collected from ED clinical staff using Likert‐type, open‐ended and dichotomous items asking about perceptions of palliative care and education needs. Comparisons were made between nursing and medical staff.ResultsMedical staff and nurses' perceptions of palliative care were similar, differing on only 10 of 37 (Likert) items. All staff reported confidence with symptom management, whereas medical staff felt more confident with decision‐oriented communication and nurses were more supportive of nasogastric feeding. Staff were moderately accurate in determining the five most common causes of death. Four out of five conditions selected as appropriate for palliative care were cancer diagnoses. End‐of‐life communication and ethical issues were the two most frequently requested areas for further education.ConclusionsOur study suggests that overall ED staff were confident regarding symptom management in palliative care. Cancer diagnoses were overrepresented in both the top five causes of death and conditions most appropriate for a palliative approach, suggesting that staff might underestimate the role of a palliative approach in non‐cancer diagnoses. Areas suggested for further education include communication and ethical issues surrounding end‐of‐life care.
Pseudoepitheliomatous hyperplasia secondary to allergic contact dermatitis to Grevillea Robyn Gordon
Authors: Meani Rowena E , Nixon Rosemary L , O'Keefe Rodney , Chong Alvin H 
Published: June 2015

AbstractWe report a case of pseudoepitheliomatous hyperplasia (PEH) in a 55‐year‐old woman following allergic contact dermatitis (ACD) to Grevillea Robyn Gordon. We believe this to be the first reported case of PEH secondary to ACD, and postulate that this was an exaggerated response to severe ACD as a result of a lack of topical treatment.
Ownership Structure and the Survival of Listed Firms: Evidence from Korean Reverse Mergers
Authors: Han Seung Hun , Kwon Yonghyun 
Published: June 2015

AbstractWe examine the impact of ownership structure on the post‐performance of Korean firms that go public as the result of a reverse merger. Although a reverse‐merger announcement has positive cumulative abnormal returns (CARs), we find that 24.8% of reverse‐merged firms become delisted because of poor post‐performance, seemingly due to the agency problem. We also find that expected changes in management after a reverse merger positively affect the CARs of public target firms around the time of the reverse‐merger announcement. However, the post‐performance of reverse‐merged firms is relatively poor compared to firms that undertake regular initial public offerings. Further, we find that ownership concentration alleviates poor performance following a reverse merger.
Anaesthetic and pharmacological techniques to decrease blood loss in liver surgery: a systematic review
Authors: Pathak Samir , Hakeem Abdul , Pike Thomas , Toogood Giles J. , Simpson Matthew , Prasad K. Raj , Miskovic Danilo 
Published: June 2015

AbstractBackgroundThere is increasing evidence that perioperative blood loss and blood transfusions are associated with poorer short‐ and long‐term outcomes in patients undergoing hepatectomy. The aim of this study was to systematically review the literature for non‐surgical measures to decrease intraoperative blood loss during liver surgery.MethodsThe literature search was performed using PubMed, Embase, Cochrane Library, CINAHL and Google Scholar databases. The primary outcome measures were perioperative blood loss and transfusion requirements. A secondary outcome measure was development of ischaemia–reperfusion injury.ResultsSeventeen studies met the inclusion criteria and included 1573 patients. All were randomized controlled studies. In eight studies (n = 894), pharmacological methods, and in another nine studies (n = 679), anaesthetic methods to decrease blood loss were investigated. Anti‐fibrinolytic drugs, acute normovolaemic haemodilution, autologous blood donation and use of inhalational anaesthetic agent may affect blood loss and post‐operative hepatic function.ConclusionsThere is potential for use of non‐surgical techniques to decrease perioperative bleeding. However, on the basis of this review alone, due to heterogeneity of randomized trials conducted, no particular strategy can be recommended. Future studies should be conducted looking at pathways to decrease bleeding in liver surgery.
Hepatic resection for malignant liver tumours in the elderly: a systematic review and meta‐analysis
Authors: Phan Kevin , An Vincent Vinh Gia , Ha Hakeem , Phan Steven , Lam Vincent , Pleass Henry 
Published: June 2015

AbstractBackgroundThe number of elderly patients undergoing hepatic resection for surgical treatment of benign and malignant cancers is increasing. However, there is limited clinical data on the complications and long‐term survival rates associated with liver surgery in the elderly patients (≥70 years) versus younger patients for malignant liver conditions.MethodsSix electronic databases were searched for original published studies comparing elderly (≥70) versus younger (<70) cohorts for malignant liver tumours. Data were extracted and analysed according to predefined clinical endpoints.ResultsTwenty‐seven comparative studies were identified, including 4769 elderly patients versus 15 855 younger patients (n = 20 624). There was significantly higher 30‐day mortality in the elderly colorectal liver metastasis group (P < 0.00002) and significant difference between elderly and young in terms of overall survival (hazard ration (HR), 1.10; P = 0.02). However, there was no difference in disease‐free survival (HR, 1.05; P = 0.27). Post‐operative pneumonia, renal failure and infection were more frequent in the elderly group.ConclusionsLiver resection for malignant hepatic tumours in the elderly is associated with a greater 30‐day mortality and overall mortality when compared with younger cohorts, but similar disease‐free survival. Length of stay and transfusions were not significantly different while pneumonia, renal failure and infections were more frequent in the elderly group.
The Activist Polis: Topologies of Conflict in Indigenous Solidarity Activism
Authors: Mott Carrie 
Published: June 2015

AbstractInterpersonal conflict poses a serious threat to social justice activism. In the context of indigenous solidarity activism in southern Arizona, conflicts are often born of the challenges accompanying differentials in social privilege due to differences in race and ethnicity relative to white supremacist settler colonialism. This paper examines activist collaboration between Tohono O'odham and non‐Native anarchist activists in southern Arizona, arguing that a topological activist polis is a useful lens through which we can better understand the roots of conflict in social justice activism. Non‐Native activists are often aware of the ways white supremacist settler colonial society privileges particular identities while marginalizing others. Nonetheless, settler and white privilege give rise to tensions which can be seen topologically through the very different relationships non‐Native and indigenous activists have to ongoing processes of white supremacy and to histories of the genocide of indigenous peoples.
What is underneath the cesarean request?
Authors: Dweik Diána , Sluijs Anne‐Marie 
Published: June 2015

AbstractIn the Nordic countries, where there is a real pursuit to keep cesarean section rates at a relatively low level, the efforts to align maternity care to the needs of women reflect a unique approach among high‐income countries. Electively performed cesarean section due to fear of childbirth is one example of this increased attention. The antenatal counseling services’ primary aim is the promotion of a positive childbirth experience, regardless of mode of delivery. It is very likely, however, that even a fulfilled request for cesarean section is not enough to ensure a positive birth experience. Therefore, a maternal request for cesarean delivery should first be interpreted as a sign of increased maternal vulnerability rather than a need that should be met unconditionally.
Systematic review: factors associated with relapse of inflammatory bowel disease after discontinuation of anti‐TNF therapy
Authors: Gisbert J. P. , Marín A. C. , Chaparro M. 
Published: June 2015

SummaryBackgroundThe discontinuation of anti‐tumour necrosis factor (anti‐TNF) treatment in inflammatory bowel disease (IBD) patients in remission could be considered.AimTo evaluate the factors associated with relapse of IBD after discontinuation of anti‐TNF therapy.MethodsElectronic (PubMed/Embase) and manual search up to January 2015.ResultsThe overall risk of relapse after discontinuation of anti‐TNFs (27 studies) was 44% for Crohn's disease (CD; follow‐up range: 6–125 months) and 38% for ulcerative colitis (follow‐up range: 6–24 months). Several factors were investigated to identify patients who are more likely to achieve long‐lasting remission after anti‐TNF discontinuation. The factors associated with a higher risk of relapse are younger age, smoking, longer disease duration, and fistulising perianal CD. Laboratory markers such as low haemoglobin levels, high C‐reactive protein levels and high faecal calprotectin seem to increase the risk of relapse. On the other hand, low serum anti‐TNF levels seem to be associated with a lower risk of flare‐up. Mucosal healing seems to decrease the risk of relapse after anti‐TNF discontinuation (overall, this risk is 26% at 1 year with mucosal healing and 42% without), although this observation has not been confirmed by some authors. In patients receiving escalated anti‐TNF doses or receiving anti‐TNFs for the prevention of post‐operative CD recurrence, the risk of relapse after discontinuation is high (>75%). Re‐administration of the drug in those who relapsed after stopping treatment is effective and safe.ConclusionsA high proportion of patients with IBD relapse after discontinuation of anti‐TNF treatment. As available data are insufficient to make strong recommendations on when anti‐TNF therapy could be stopped, decisions should be taken on an individual basis.
High Helicobacter pylori cure rate with sitafloxacin‐based triple therapy
Authors: Sugimoto M. , Sahara S. , Ichikawa H. , Kagami T. , Uotani T. , Furuta T. 
Published: June 2015

SummaryBackgroundBacterial resistance of Helicobacter pylori to antibiotics is increasing and it often leads to failure of antibiotic treatment. A new sitafloxacin‐based triple therapy was developed to counter this situation; the fluoroquinolone sitafloxacin has a low minimum inhibitory concentration for H. pylori.AimTo investigate the efficacy in Japanese patients of sitafloxacin‐based triple therapy and document its efficacy in relation to anti‐microbial susceptibility.MethodsWe investigated the efficacy of a 1‐week sitafloxicin‐based regimen of rabeprazole 10 mg four times daily (q.d.s.), metronidazole 250 mg twice daily (b.d.) and sitafloxacin 100 mg b.d. in 180 H. pylori‐positive Japanese patients (first‐line treatment: n = 45, second‐line; n = 41, third‐line: n = 94). At 8 weeks, patients were given the 13C‐urea breath test to assess eradication status.ResultsEradication rate was 92.2% [95% confidence interval (CI): 87.3–95.7%, 166/180] in intention‐to‐treat analysis. Although the eradication rate was higher in patients treated with first‐line therapy [45/45 (100%, 95% CI: 83.4–100%)] than in those with second‐ [38/41 (92.7%, 80.1–98.5%)] or third‐line therapy [83/94 (88.3%, 80.0–94.0%)], no significant differences were noted with respect to the number of previous therapy attempts (P = 0.054). Eradication rates in patients infected with sensitive‐ and resistant strains to metronidazole were 96.6% (28/29) and 96.3% (77/80) (P = 0.941), respectively, while rates were 98.4% (60/61) in sitafloxacin‐sensitive and 50.0% (1/2) in sitafloxacin resistant strains (P < 0.001).ConclusionSitofloxacin‐based triple therapy with metronidazole b.d. and rabeprazole q.d.s. achieved an eradication rate exceeding 88%, irrespective of eradication history, CYP2C19 genotype, or metronidazole resistance status.
Inter‐study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta‐analysis
Authors: Gotta V , Cools F , van Ammel K , Gallacher D J , Visser S A G , Sannajust F , Morissette P , Danhof M , van der Graaf P H 
Published: June 2015

Background and PurposePreclinical cardiovascular safety studies (CVS) have been compared between facilities with respect to their sensitivity to detect drug‐induced QTc prolongation (ΔQTc). Little is known about the consistency of quantitative ΔQTc predictions that are relevant for translation to humans.Experimental ApproachWe derived typical ΔQTc predictions at therapeutic exposure (ΔQTcTHER) with 95% confidence intervals (95%CI) for 3 Kv11.1 (hERG) channel blockers (moxifloxacin, dofetilide and sotalol) from a total of 14 CVS with variable designs in the conscious dog. Population pharmacokinetic‐pharmacodynamic (PKPD) analysis of each study was followed by a meta‐analysis (pooling 2–6 studies including 10–32 dogs per compound) to derive meta‐predictions of typical ΔQTcTHER. Meta‐predictions were used as a reference to evaluate the consistency of study predictions and to relate results to those found in the clinical literature.Key ResultsThe 95%CIs of study‐predicted ΔQTcTHER comprised in 13 out of 14 cases the meta‐prediction. Overall inter‐study variability (mean deviation from meta‐prediction at upper level of therapeutic exposure) was 30% (range: 1–69%). Meta‐ΔQTcTHER predictions for moxifloxacin, dofetilide and sotalol overlapped with reported clinical QTc prolongation when expressed as %‐prolongation from baseline.Conclusions and ImplicationsConsistent exposure‐ΔQTc predictions were obtained from single preclinical dog studies of highly variable designs by systematic PKPD analysis, which is suitable for translational purposes. The good preclinical–clinical pharmacodynamic correlations obtained suggest that such an analysis should be more routinely applied to increase the informative and predictive value of results obtained from animal experiments.
Pleiotropic, heart rate‐independent cardioprotection by ivabradine
Authors: Kleinbongard P , Gedik N , Witting P , Freedman B , Klöcker N , Heusch G 
Published: June 2015

Background and PurposeIn pigs, ivabradine reduces infarct size even when given only at reperfusion and in the absence of heart rate reduction. The mechanism of this non‐heart rate‐related cardioprotection is unknown. Hence, in the present study we assessed the pleiotropic action of ivabradine in more detail.Experimental ApproachAnaesthetized mice were pretreated with ivabradine (1.7 mg·kg−1 i.v.) or placebo (control) before a cycle of coronary occlusion/reperfusion (30/120 min ± left atrial pacing). Infarct size was determined. Isolated ventricular cardiomyocytes were exposed to simulated ischaemia/reperfusion (60/5 min) in the absence and presence of ivabradine, viability was then quantified and intra‐ and extracellular reactive oxygen species (ROS) formation was detected. Mitochondria were isolated from mouse hearts and exposed to simulated ischaemia/reperfusion (6/3 min) in glutamate/malate‐ and ADP‐containing buffer in the absence and presence of ivabradine respectively. Mitochondrial respiration, extramitochondrial ROS, mitochondrial ATP production and calcium retention capacity (CRC) were assessed.Key ResultsIvabradine decreased infarct size even with atrial pacing. Cardiomyocyte viability after simulated ischaemia/reperfusion was better preserved with ivabradin, the accumulation of intra‐ and extracellular ROS decreased in parallel. Mitochondrial complex I respiration was not different without/with ivabradine, but ivabradine significantly inhibited the accumulation of extramitochondrial ROS, increased mitochondrial ATP production and increased CRC.Conclusion and ImplicationsIvabradine reduces infarct size independently of a reduction in heart rate and improves ventricular cardiomyocyte viability, possibly by reducing mitochondrial ROS formation, increasing ATP production and CRC.
La fonction publique canadienne a perdu ses repères
Authors: Savoie Donald J. 
Published: June 2015

SommaireIl y a une trentaine d'années, dans les démocraties anglo‐américaines, les politiciens ont adopté une série de mesures conçues pour leur assurer une position dominante dans l'élaboration des politiques publiques et pousser les hauts fonctionnaires à devenir de meilleurs gestionnaires. Le gouvernement du Canada n'y a pas fait exception. Essentiellement, les politiciens ont décidé de se tourner vers le secteur privé pour améliorer la gestion du secteur public. Ces efforts ont échoué, ont coûté cher aux contribuables et ont rompu les amarres de la fonction publique fédérale. Cet article soutient que la fonction publique a besoin de redécouvrir ses racines, et qu'elle doit abandonner les hypothèses simples liées aux intérêts personnels et aux modèles déductifs et le mantra voulant que les réformes inspirées du secteur privé puissent engendrer des changements productifs dans le secteur public.