bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methoxyflurane analgesia for outpatient hysteroscopy: A double‐blind, randomised, controlled trial
Authors: Twidale Emily K. , Neutens Sofie , Hynt Lyn , Dudley Narena , Streeton Catherine 
Published: July 2024

BackgroundDespite clinical and economic benefits, pain during outpatient hysteroscopy (OPH) remains a barrier to use. There is a lack of evidence to support routine use of one analgesic over another versus no analgesic.AimsTo study the efficacy and safety of methoxyflurane analgesia during OPH.Materials and MethodsA single‐centre, randomised, double‐blind, placebo‐controlled experiment was performed; 90 patients were randomly assigned (1:1). Participants allocated to the treatment group (cases) received 3 mL of methoxyflurane through an inhaler. The control group received a placebo. The primary outcome was a mean difference in pain, via a change in Visual Analog Scale (VAS) score from baseline at diagnostic hysteroscopy. Secondary outcomes were a mean difference in VAS score with any subsequent operative procedures; a mean difference in VAS score at 15 min post‐procedure; participant and clinician‐reported adverse effects and events; and participant‐reported procedure acceptability, adjuvant nitrous oxide (N2O2) use and a composite of ‘distress’.ResultsDuring diagnostic hysteroscopy, there was a mean difference of 11.5 mm/100 (95% confidence interval (CI) 0.08–22.95), P = 0.05, with the lower score in the cases, compared with controls. During subsequent operative procedures, there was a mean difference of 15 mm/100 (95% CI 2.71–28.22), P = 0.02, with the lower pain score in the cases, compared with controls. There was no significant difference in pain 15 min post‐procedure, participant‐ and clinician‐ reported adverse effects and events, procedure acceptability and the ‘distress’ composite.ConclusionsMethoxyflurane significantly reduced pain during OPH compared with placebo, for diagnostic as well as operative procedures. Furthermore, methoxyflurane was well tolerated, with no adverse events.
Indigenous Natures and the Anthropocene: Racial Capitalism, Violent Materialities, and the Colonial Politics of Representation
Authors: Anthias Penelope , Asher Kiran 
Published: July 2024

AbstractIndigenous Peoples are gaining renewed attention within both policy and academia, as examples of “resilience” and of non‐humanist, non‐modern ways of relating to nature, which might, it is hoped, provide tools to withstand the socio‐ecological crises associated with “the Anthropocene”. This paper argues that such representations obscure both their own colonial foundations and the ongoing forms of racialised dispossession and ecocide faced by Indigenous Peoples today. Instead, we conceptualise indigeneity and nature as deeply entangled categories that are co‐produced with capitalist modernity. Engaging anti‐colonial and Marxist scholarship, and drawing on our long‐term research with Indigenous movements in Bolivia and Colombia, we highlight how discursive and material assemblages of indigeneity and nature are dialectically linked to capitalist processes of dispossession and subaltern efforts to contest these. We further highlight how romanticised accounts of non‐modern nature‐cultures are unsettled by the violent world‐making of colonial capitalism and the unequal burdens placed on Indigenous territories and bodies. We use an ethnographic vignette from the Bolivian Chaco to illustrate the messy everyday ways in which real Indigenous people navigate, contest, endure, and make do amidst the contradictory processes of racialisation, dispossession, and conditional recognition that characterise their positioning within colonial capitalism. In doing so, we show how thinking from the sacrifice zones of extractive capitalism unsettles contemporary debates on decolonising nature in the Anthropocene.
FOXM1/DEPDC1 feedback loop promotes hepatocarcinogenesis and represents promising targets for cancer therapy
Authors: Wei Teng , Zeng Chenquan , Li Qineng , Xiao Zhiyuan , Zhang Leisheng , Zhang Qiangnu , Ren Lili 
Published: July 2024

AbstractForkhead box M1 (FOXM1) is a key regulator of mitosis and is identified as an oncogene involved in several kinds of human malignancies. However, how it induces carcinogenesis and related therapeutic approaches remains not fully understood. In this study, we aimed to identify a regulatory axis involving FOXM1 and its target gene DEP domain containing 1 (DEPDC1) and investigate their biological functions. FOXM1 bound to the promoter and transcriptionally induced DEPDC1 expression, in turn, DEPDC1 physically interacted with FOXM1, promoted its nuclear translocation, and reinforced its transcriptional activities. The FOXM1/DEPDC1 axis was indispensable for cancer cells, as evidenced by the fact that DEPDC1 rescued cell growth inhibition caused by FOXM1 knockdown, and silencing DEPDC1 efficiently attenuated tumor growth in a murine hepatocellular carcinoma model. Furthermore, strong positive associations between FOXM1/DEPDC1 axis and poor clinical outcome were observed in human hepatocellular carcinoma samples, further indicating their significance for hepatocarcinogenesis. Finally, we attempted to exploit immunotherapy approaches to target the FOXM1/DEPDC1 axis. Several HLA‐A24:02‐restricted T‐cell epitopes targeting FOXM1 or DEPDC1 were identified through bioinformatic analysis. Then, T cell receptor (TCR)‐engineered T cells targeting FOXM1262‐270 or DEPDC1294‐302 were successfully established and proved to efficiently eradicate tumor cells. Our findings highlight the significance of the FOXM1/DEPDC1 axis in the process of oncogenesis and indicate their potential as immunotherapy targets.
Clinically amyopathic dermatomyositis: Clinical, laboratory, and histopathological features
Authors: Wang Xintong , De Moll Ellen , Koschitzky Merav , Shihab Nahla , Khattri Saakshi , Phelps Robert 
Published: July 2024

AbstractBackgroundDespite the advancements in the categorization of clinically amyopathic dermatomyositis (CADM), the classification and diagnosis of its subtypes are still challenging. The aim of our study was to describe the clinicopathological features of CADM and assess the differences between amyopathic dermatomyositis (ADM) and hypomyopathic dermatomyositis (HDM).MethodsThis retrospective study included 43 patients with CADM diagnosed at our institution from 2016 to 2020. Patients were subclassed into ADM (n = 30) and HDM (n = 13) groups to assess their clinicopathological differences.ResultsAll included patients had characteristic cutaneous manifestations of dermatomyositis; 67.4% had myositis‐associated auto‐antibodies, including ANA (32.6%), RNP (14.0%), anti‐Ro52 (9.3%), anti‐p155/140 (7.0%), rheumatoid factor (7.0%), anti‐NXP‐2 (4.7%), anti‐MDA5 (2.3%), and anti‐Jo‐1 (2.3%) antibodies. One patient had associated interstitial lung disease, and another patient had oral squamous cell carcinoma. The histopathological findings included mucin deposition (69.8%), telangiectasia (65.1%), lymphocytic infiltrate (48.8%), vacuolar interface dermatitis (46.5%), and epidermal atrophy (14.0%). Compared to patients with HDM, ADM patients were significantly less likely to have epidermal atrophy, 3.3% versus 38.5% (p = 0.006), and more likely to have mucin deposition, 80.0% versus 46.2% (p = 0.028).ConclusionWe described the clinicopathological features of CADM and highlighted the distinctions between ADM and HDM dermatopathologic findings. This information may prove helpful in diagnosing ambiguous lesions.
Accessing supports due to others' harmful drinking
Authors: Rintala Jade , Smit Koen , Room Robin , Jiang Heng , Laslett Anne‐Marie 
Published: July 2024

AbstractIntroductionAlcohol's harm to others (AHTO) refers to harms caused to those other than the drinker. The current paper estimates the prevalence of formal and informal supports sought due to AHTO and examines whether the type of support accessed varies by sociodemographic, economic and harm‐related characteristics.MethodsAn Australian sample of 2574 people completed the 2021 AHTO survey, out of which 888 perceived they experienced harm from another's drinking. Prevalence of accessing services and supports was measured. Additionally, several sociodemographic factors, economic factors and harm‐related factors were included in multivariable logistic regression models predicting service/support use. Specifically, four models were constructed probing use of any service/support, use of police, use of counselling services and use of family/friend support.ResultsOf the survey sample, 12.4% accessed any support/service. Seeking support from family and/or friends was most common, followed by police, counselling, healthcare services and being admitted to hospital. Women had higher odds of accessing counselling and family/friend support. Respondents with a higher education level and two or more financial stressors had higher odds of accessing police and counselling. Respondents harmed by a stranger had higher odds of accessing police, whereas respondents harmed by someone they know had higher odds of seeking support from family/friends. Experiencing more severe harm was associated with greater odds of accessing any support.Discussion and ConclusionsSeveral sociodemographic and economic factors were associated with accessing different supports. These findings may inform service development, interventions and policy changes for people affected by others' drinking.
Climatic fluctuations, geographic features, and evolutionary forces: Shaping high genomic diversity and local adaptation in Muntiacus reevesi
Authors: Chen Guotao , Sun Zhonglou , Shi Wenbo , Wang Hui , Shi Guohui , Hu Yibo , Fan Huizhong , Wu Qi , Zhang Baowei 
Published: July 2024

AbstractAimGenetic diversity is crucial for species adaptability. Understanding the mechanisms behind its formation and maintenance is essential for effective conservation. Recent studies have demonstrated that despite experiencing severe population bottlenecks, Muntiacus reevesi retains high genetic diversity and continues its northward migration, indicative of ongoing adaptive evolution. However, our comprehension of this phenomenon remains incomplete. The objective of this study is to explore the mechanisms underlying the formation of high genetic diversity and the genomic characteristics associated with local adaptation, using M. reevesi as a case study.LocationSouthern China.MethodsWe analysed resequencing data from 62 genomes and identified 29,124,081 high‐quality single‐nucleotide polymorphisms (SNPs). We used population genetics, demographic history, population differentiation, gene flow analysis software, and genotype‐environment association (GEA) models to assess the factors that have contributed to high genetic diversity and environmental adaptability in the historical climate and geographical context.ResultsThe study identified that during Pleistocene climatic fluctuations, M. reevesi diverged into eastern (DB and WJW populations) and western lineages (WL, BA, and QL populations), all displayed high genetic diversity. Historically, M. reevesi maintained large effective populations, but contemporary human‐induced threats have led to a significant decline. Population differentiation models suggest distinct expansion pathways for eastern and western lineages, resulting in population admixture, with mountain corridors facilitating gene flow and maintaining high genetic diversity. Additionally, environmental‐genotype analysis revealed local adaptation in the QL‐BA population, highlighting candidate adaptive genes (ME3 and PRKG1) potentially linked to cold adaptation and foraging behaviour.ConclusionThis study enhances our understanding of the mechanisms behind the high genetic diversity and environmental adaptability of M. reevesi, offering insights into how bottleneck populations maintain diversity, crucial for biogeographic research and conservation strategies for similar species.
Does use of formal and informal credit reduce poverty in rural Mexico?
Authors: van Gameren Edwin , García‐Mora Fernando , Mora‐Rivera Jorge 
Published: July 2024

AbstractMotivationDespite efforts to reduce poverty, both income and multidimensional poverty continue to be high in Mexico, especially in rural areas. Most studies concerned with the effect of credit use on poverty analyse formal credit, but little is known about the impacts of different types of credit on poverty.PurposeWe investigate the impacts of the use of formal credit and informal loans obtained (primarily) for productive and investment purposes on multidimensional and income poverty of rural households in Mexico.Approach and methodsWe use data from the 2013 and 2015 CONEVAL Surveys of Rural Households in Mexico, representative of rural communities with fewer than 2,500 inhabitants, to investigate the impact of credit on poverty. We apply inverse probability of treatment weighting (IPTW) to account for differences between users of formal credit, users of informal loans, and non‐users of credit.FindingsBoth formal and informal credit usage reduce poverty in rural Mexico, generally with clearer impacts on moderate rather than extreme poverty. Informal credit appears to have largely reached households that could most benefit from it. Broader access to formal credit would potentially further reduce poverty.Policy implicationsPublic policies to reduce rural poverty should promote a greater access to the formal financial sector. Including vulnerable low‐income rural households in formal finance should be accompanied by financial education.
Assessment of cancer therapy‐related cardiac dysfunction in breast cancer women using a new speckle tracking echocardiography index: The GAVS
Authors: Di Lisi Daniela , Madaudo Cristina , Ortello Antonella , Rubino Luigi , Scelfo Domenico , Sinagra Francesco Paolo , Comparato Francesco , Triolo Oreste Fabio , Rossetto Ludovico , Galassi Alfredo Ruggero , Novo Giuseppina 
Published: July 2024

AbstractBackgroundRecently, peak atrial longitudinal strain (PALS) has emerged as a possible predictor of Cancer therapy‐related cardiac dysfunction (CTRCD) in cancer patients (CP), in addition to left ventricular global longitudinal strain (GLS). Thus, considering the link between left atrium and left ventricle, the aim of this study was to assess the global atrio‐ventricular strain (GAVS) in CP, to detect early cardiotoxicity.MethodsA prospective study was carried out enrolling 131 breast cancer women (mean age 51.4 ± 10.4 years) receiving anti‐cancer treatment. Clinical and echocardiographic evaluation was performed at baseline (T0), 3 (T1), 6 (T2) and 12 months (T3) after starting treatment. CTRCD was defined according to the 2022 ESC Cardio‐Oncology guidelines.ResultsForty‐four patients developed CTRCD (3 moderate and 41 mild CTRCD group A) and 87 patients did not (group B). In group A, significant changes in GLS, PALS, GAVS, LASi (left atrial stiffness index) and LVEF/GLS occurred earlier than LVEF, that reduced significantly only at T3 (p‐value < .05). Significant changes in LASi, PALS and GAVS occurred even in group B but reduction in GAVS (−21% vs. −5%) and PALS (−24% vs. −12%) was significantly greater in group A compared to group B (p‐value = .04).ConclusionsOur study confirms high sensitivity of speckle tracking echocardiography in detecting subclinical myocardial damage in CP and the usefulness of a multiparametric echocardiographic evaluation including PALS and GLS (GAVS) for having a global evaluation of the phenomenon cardiotoxicity.
Comparative in‐vitro analysis of amniotic Fluid's efficacy in sustaining viability and regulating apoptosis of periodontal fibroblasts versus HBSS
Authors: Harjai Gunica , Shanbhog Raghavendra 
Published: July 2024

AbstractBackgroundTooth avulsion necessitates swift replantation, for which the preservation of periodontal ligament (PDL) cell viability is paramount. Various storage media have been explored, yet a comparison between amniotic fluid (AF) obtained at different gestational stages (amniocentesis and full‐term) and HBSS is lacking.AimThis study aims to evaluate AF (amniocentesis and full‐term) against HBSS in sustaining PDL cell viability and regulating apoptosis at different time points.Material and MethodsPeriodontal fibroblasts cultured in α‐MEM were treated with 100% AF (amniocentesis), 100% AF (full‐term), and HBSS, incubated for 1, 3, 24, and 48 h at 37°C, and assessed using the MTT assay for viability and AO/EB staining for apoptosis, which was analyzed via fluorescent microscopy after 24 h. Statistical analysis was conducted using one‐way ANOVA, multivariate ANOVA, and post hoc Tukey's multiple comparison tests (p < .05).ResultsAmniotic fluid (amniocentesis) exhibited the highest optical density (OD), which implies the highest cell viability across time intervals, followed by AF (full‐term) and HBSS. While HBSS maintained PDL morphology, both AF groups showed altered morphology. No cell death was observed after 24 h.ConclusionsWithin the limitations of this study, both AF groups showed the potential to sustain PDL cell viability after 1, 3, 24, and 48 h of storage. However, further investigation is warranted regarding their suitability as storage media.
Like coloured pencils in a pencil case: A portray of the connections between learning style preferences, needs satisfaction, academic motivation, and psychological well‐being from the window of self‐determination theory
Authors: Namaziandost Ehsan , Kargar Behbahani Hossein , Heydarnejad Tahereh 
Published: July 2024

AbstractSelf‐determination theory (SDT) has been the subject of pioneering studies in recent years. SDT is centered on the basic psychological needs of autonomy, competence, and relatedness and their necessary role in self‐determined motivation, well‐being, and growth. The objective of the present research was to investigate the relationships between learning style preference, motivational regulation, and psychological well‐being of 417 EFL students at the intermediate level in private schools in three provinces in Iran. The researchers collected the data via electronic surveys using the Perceptual Learning Style Preference Questionnaire, Academic Motivation (AM) Scale, Basic Psychological Needs Satisfaction Measure, and Psychological Well‐Being (PWB) Scale. The quantitative analyses using structural equation modelling showed positive correlations between the learning style preferences and AM and the PWB. Moreover, the satisfaction level with needs was a significant factor in predicting AM and PWB scores. The study highlights the importance of recognizing and accommodating diverse learning styles in educational settings and the significance of needs satisfaction in fostering intrinsic motivation and overall well‐being among EFL learners. These findings emphasize the need for practitioners to target and tailor their pedagogical strategies to meet the needs of their learners and create a learning environment that fosters the three psychological needs as determined by SDT.
Experience and naturalism
Authors: Zweber Adam 
Published: July 2024

AbstractMuch of contemporary metaethics revolves around the issue of “naturalism.” However, there is little agreement on what “naturalism” is or why it should be of significance. In this paper, I aim to rectify this situation by providing a set of necessary conditions on what positions ought to count as “naturalistic.” A metaethical view should count as an instance of naturalism only if it claims that there can be evidence for normative claims that is both public and spatiotemporal. I argue that, unlike other characterizations of “naturalism,” this view shows a clear difference between many metaethical positions and the sciences. The view thereby renders debates about naturalism philosophically significant: the division between naturalists and non‐naturalists is that between philosophers who hold that ethics is relevantly similar to the sciences and those who deny this.
Forecasting potential invaders to prevent future biological invasions worldwide
Authors: Pili Arman N. , Leroy Boris , Measey John G. , Farquhar Jules E. , Toomes Adam , Cassey Phillip , Chekunov Sebastian , Grenié Matthias , van Winkel Dylan , Maria Lisa , Diesmos Mae Lowe L. , Diesmos Arvin C. , Zurell Damaris , Courchamp Franck , Chapple David G. 
Published: July 2024

AbstractThe ever‐increasing and expanding globalisation of trade and transport underpins the escalating global problem of biological invasions. Developing biosecurity infrastructures is crucial to anticipate and prevent the transport and introduction of invasive alien species. Still, robust and defensible forecasts of potential invaders are rare, especially for species without known invasion history. Here, we aim to support decision‐making by developing a quantitative invasion risk assessment tool based on invasion syndromes (i.e., generalising typical attributes of invasive alien species). We implemented a workflow based on ‘Multiple Imputation with Chain Equation’ to estimate invasion syndromes from imputed datasets of species' life‐history and ecological traits and macroecological patterns. Importantly, our models disentangle the factors explaining (i) transport and introduction and (ii) establishment. We showcase our tool by modelling the invasion syndromes of 466 amphibians and reptile species with invasion history. Then, we project these models to amphibians and reptiles worldwide (16,236 species [c.76% global coverage]) to identify species with a risk of being unintentionally transported and introduced, and risk of establishing alien populations. Our invasion syndrome models showed high predictive accuracy with a good balance between specificity and generality. Unintentionally transported and introduced species tend to be common and thrive well in human‐disturbed habitats. In contrast, those with established alien populations tend to be large‐sized, are habitat generalists, thrive well in human‐disturbed habitats, and have large native geographic ranges. We forecast that 160 amphibians and reptiles without known invasion history could be unintentionally transported and introduced in the future. Among them, 57 species have a high risk of establishing alien populations. Our reliable, reproducible, transferable, statistically robust and scientifically defensible quantitative invasion risk assessment tool is a significant new addition to the suite of decision‐support tools needed for developing a future‐proof preventative biosecurity globally.
Superior comprehensive performance CaO‐based core achieved by optimizing particle gradation via orthogonal experiments
Authors: Huang Jiefei , Liu Fuchu , Han Guangchao , Fan Zitian 
Published: July 2024

AbstractThe effect of CaCO3 particle size on the viscosity of slurry, phase formation, microstructural evolution, and performances of the water‐soluble CaO‐based ceramic core sintered at different temperatures was systematically investigated and discussed, and the particle gradation orthogonal experiments were used to adjust flexural strength, water‐soluble rate, shrinkage rate, apparent porosity, and hygroscopicity rate. The results showed that the finer particle size increased the effective contact area between CaO and SiO2, which promoted the generation of CaO–SiO2 system phase and the dense microstructure in the sintered CaO‐based cores. The higher sintering resulted in dense microstructure. The optimal gradation scheme included 28 wt.%, 56 wt.%, and 16 wt.% CaCO3 powder with D50 = 11.0 µm, 6.17 µm, and 4.62 µm, respectively, and the resulting flexural strength was 9.57 MPa, water‐soluble rate was 65.37 g/h in 60°C water, shrinkage rate was 8.62%, porosity rate was 38.85%, presenting a well‐balanced comprehensive performance, which is significant for the complex internal castings.