bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship between Temperamental Negative Affect, Effortful Control, and Sensory Regulation: A New Look
Authors: Gouze Karen R. , Lavigne John V. , Hopkins Joyce , Bryant Fred B. , Lebailly Susan A. 
Published: November 2012

AbstractTemperamental negative affectivity (NA) and effortful control (EC) have long been of interest to psychologists, but sensory regulation (SR) has received less attention. Using confirmatory factor analysis, the present study reexamined the Rothbart model of EC and NA using the Children's Behavior Questionnaire (CBQ; M.K. Rothbart, S.A. Ahadi, K.L. Hershy, & P. Fisher, 2001), along with alternative models of EC, NA, and SR using the CBQ and Short Sensory Profile. The results failed to replicate the Rothbart model of EC and NA, which includes SR within the EC and NA factors. A good fit was found for a three‐factor model (EC, NA, and SR) that was replicated in a holdout sample. A three‐factor model also showed a good fit when EC, NA, and SR items similar to symptoms of behavior problems were eliminated.
Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: A randomized clinical trial
Authors: Chilibeck Philip D , Vatanparast Hassanali , Pierson Roger , Case Allison , Olatunbosun Olufemi , Whiting Susan J , Beck Thomas J , Pahwa Punam , Biem H Jay 
Published: November 2012

Abstract
We determined the effects of 2 years of exercise training and soy isoflavone supplementation on bone mass and lipids in postmenopausal women provided with calcium and vitamin D. Women were randomized to four groups: exercise training (Ex); isoflavone supplementation (Iso: 165 mg/d [105 mg/d aglycone equivalent]); combined Ex and Iso (ExIso); and placebo (control). Exercise included resistance training (2 days/week) and walking (4 days/week). Our primary outcomes were lumbar spine and hip bone mineral density (BMD). Secondary outcomes included hip geometry, tibia and radius speed of sound (SOS), dynamic balance (6 m backward tandem walking), blood lipids, mammography, and endometrial thickness. A total of 351 women (Ex = 86, Iso = 90, ExIso = 87, control = 88) were randomized, with 298 analyzed at 2 years (Ex = 77, Iso = 76, ExIso = 72, control = 73). There was a significant interaction for total hip BMD (p &lt; 0.001) such that ExIso had a greater rate of decrease (absolute change [95% confidence interval] = −0.018 [−0.024, −0.012] g/cm2) than either the Ex or Iso groups alone (−0.005 [−0.01, 0.001] and −0.005 [−0.011, 0.001] g/cm2, respectively). There were no differences between groups for changes in lumbar spine BMD and minimal significant changes in hip geometric properties and bone SOS. Exercise groups improved dynamic balance as measured by a decrease in backward tandem walking time over 6 m (p = 0.017). Isoflavone groups decreased low density lipoproteins (Iso: −0.20 [−0.37, −0.02] mmol/L; ExIso: −0.23 [−0.40, −0.06] mmol/L; p = 0.003) compared to non-isoflavone groups (Ex: 0.01 [−0.16, 0.18] mmol/L; control: −0.09 [−0.27, 0.08] mmol/L) and had lower adverse reports of menopausal symptoms (14% versus 33%; p = 0.01) compared to non-isoflavone groups. Isoflavone supplementation did not increase endometrial thickness or abnormal mammograms. We conclude exercise training and isoflavone supplementation maintain hip BMD compared to control, but these two interventions interfere with each other when combined. Isoflavone supplementation decreased LDL and adverse events related to menopausal symptoms. © 2013 American Society for Bone and Mineral Research.
Synthesis and Qualitative Analysis of BACy and Its Self‐polymer
Authors: Lin Yan‐Su , Lee Hsuan‐Hsuan , Lee Wen‐Fu , Lin Chao‐Hsiung 
Published: November 2012

AbstractMany synthetic strategies of a reversible cross‐linker N,N′‐bis(acryloyl)cystamine (BACy) involve the typical condensation between the amino group of cystamine and the acyl group of acryloyl chloride in the mixed‐phase solvent system. In this study, the synthesis of BACy was performed in pure organic phase during the whole process. The yield and purity of synthesized BACy were comparable to those from aqueous/organic phase procedures. In addition, polymerization of BACy was also carried out by free radical reaction to prepare the self‐polymer and hydrogel which were characterized with FT‐IR, DSC and UV/VIS spectrophotometer. Notably, the BACy and its self‐polymer were both cleavable when exposed to the reducing agents, i.e. 1,4‐dithiothreitol (DTT) and 2‐mercaptoethanol (β‐ME). Interestingly, the reduced product of BACy contains vinyl and thiol groups, which could be further applied to the co‐polymerization with other monomeric units. On the other hand, carefully controlled reduction of BACy self‐polymer may be used to create the modified polymers with available thiol‐end groups for further chemistry. Together, our study provides modified procedure for BACy synthesis and characteristics of BACy self‐polymer and hydrogel. Further application of BACy and its self‐polymer in developing polymers with additional functionality is anticipated.
Euphorbiane: A Novel Triterpenoid with an Unprecedented Skeleton from Euphorbia tirucalli
Authors: Yu Hsi‐Jung , Shen Chien‐Chang , Yi Hsiu‐Mei , Chen Tai‐Hung , Hsueh Mao‐Lin , Lin Chu‐Chieh , Don Ming‐Jaw 
Published: November 2012

AbstractEuphorbiane (1), a novel triterpenoid exhibiting a unique skeleton, together with seven known compounds were isolated from the 95% EtOH extract of the fresh stems of Euphorbia tirucalli. The structure of 1 and relative stereochemistry were elucidated by extensive NMR and a single‐crystal X‐ray crystallographic analysis.
Zolpidem is independently associated with increased risk of inpatient falls
Authors: Kolla Bhanu Prakash , Lovely Jenna K. , Mansukhani Meghna P. , Morgenthaler Timothy I. 
Published: November 2012

AbstractBACKGROUND:Inpatient falls are associated with significant morbidity and increased healthcare costs. Zolpidem has been reported to decrease balance and is associated with falls. Yet, it is a commonly used hypnotic agent in the inpatient setting. Zolpidem use in hospitalized patients may be a significant and potentially modifiable risk factor for falling.OBJECTIVE:To determine whether inpatients administered zolpidem are at greater risk of falling.DESIGN:Retrospective cohort study.SETTING:Adult non‐intensive care unit (non‐ICU) inpatients at a tertiary care center.METHODS:Adult inpatients who were prescribed zolpidem were identified. Electronic medical records were reviewed to capture demographics and other risk factors for falls. The fall rate was compared in those administered zolpidem versus those only prescribed zolpidem. Multivariate analyses were performed to determine whether zolpidem was independently associated with falls.RESULTS:The fall rate among patients who were prescribed and received zolpidem (n = 4962) was significantly greater than among patients who were prescribed but did not receive zolpidem (n = 11,358) (3.04% vs 0.71%; P < 0.001). Zolpidem use continued to remain significantly associated with increased fall risk after accounting for age, gender, insomnia, delirium status, dose of zolpidem, Charlson comorbidity index, Hendrich's fall risk score, length of hospital stay, presence of visual impairment, gait abnormalities, and dementia/cognitive impairment (adjusted odds ratio [OR] 4.37, 95% confidence interval [CI] = 3.34–5.76; P < 0.001). Additionally, patients taking zolpidem who experienced a fall did not differ from other hospitalized adult patients who fell in terms of age, opioids, antidepressants, sedative‐antidepressants, antipsychotics, benzodiazepine, or antihistamine use.CONCLUSION:Zolpidem use was a strong, independent, and potentially modifiable risk factor for inpatient falls. Journal of Hospital Medicine 2013. © 2012 Society of Hospital Medicine
Evaluation of chondral repair using quantitative MRI
Authors: Nieminen Miika T. , Nissi Mikko J. , Mattila Lauri , Kiviranta Ilkka 
Published: November 2012

AbstractVarious quantitative magnetic resonance imaging (qMRI) biomarkers, including but not limited to parametric MRI mapping, semiquantitative evaluation, and morphological assessment, have been successfully applied to assess cartilage repair in both animal and human studies. Through the interaction between interstitial water and constituent macromolecules the compositional and structural properties of cartilage can be evaluated. In this review a comprehensive view of a variety of quantitative techniques, particularly those involving parametric mapping, and their relationship to the properties of cartilage repair is presented. Some techniques, such as T2 relaxation time mapping and delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC), are well established, while the full potential of more recently introduced techniques remain to be demonstrated. A combination of several MRI techniques is necessary for a comprehensive characterization of chondral repair. J. Magn. Reson. Imaging 2012; 36:1287–1299. © 2012 Wiley Periodicals, Inc.
Assessment of contrast‐enhanced computed tomography for imaging of cartilage during fracture healing
Authors: Hayward Lauren N.M. , de Bakker Chantal M.J. , Gerstenfeld Louis C. , Grinstaff Mark W. , Morgan Elise F. 
Published: November 2012

AbstractAssessment of the early stages of fracture healing via X‐rays and computed tomography is limited by the low radio‐opacity of cartilage. We validated a method of contrast‐enhanced computed tomography (CECT) for non‐destructive identification of cartilage within a healing fracture callus. Closed, stabilized fractures in femora of C57BL/6 mice were harvested on post‐operative day 9.5 and imaged ex vivo with micro‐computed tomography (µCT) before and after incubation in a cationic contrast agent that preferentially accumulates in cartilage due to the high concentration of sulfated glycosaminoglycans in the tissue. Co‐registration of the pre‐ and post‐incubation images, followed by image subtraction, enabled two‐ and three‐dimensional delineation of mineralized tissue, soft callus, and cartilage. The areas of cartilage and callus identified with CECT were compared to those identified with the gold‐standard method of histomorphometry. No difference was found between the areas of cartilage measured by the two methods (p = 0.999). Callus area measured by CECT was smaller than, but strongly predictive of (R2 = 0.80, p < 0.001), the corresponding histomorphometric measurements. CECT also enabled qualitative identification of mineralized cartilage. These findings indicate that the CECT method provides accurate, quantitative, and non‐destructive visualization of the shape and composition of the fracture callus, even during the early stages of repair when little mineralized tissue is present. The non‐destructive nature of this method would allow subsequent analyses, such as mechanical testing, to be performed on the callus, thus enabling higher‐throughput, comprehensive investigations of bone healing. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 567–573, 2013
In vitro 3D Full‐Thickness Skin‐Equivalent Tissue Model Using Silk and Collagen Biomaterials
Authors: Bellas Evangelia , Seiberg Miri , Garlick Jonathan , Kaplan David L. 
Published: November 2012

AbstractCurrent approaches to skin equivalents often only include the epidermis and dermis. Here, a full‐thickness skin equivalent is described including epidermis, dermis, and hypodermis, that could serve as an in vitro model for studying skin biology or as a platform for consumer product testing. The construct is easy to handle and is maintained for >14 d while expressing physiological morphologies of the epidermis and dermis, seen by keratin 10, collagens I and IV expression. The skin equivalent produces glycerol and leptin, markers of adipose metabolism. This work serves as a foundation for understanding a few necessary factors needed to develop a stable, functional model of full‐thickness skin. magnified image
Which Polyesters Can Mimic Polyethylene?
Authors: Stempfle Florian , Ortmann Patrick , Mecking Stefan 
Published: November 2012

AbstractSelf‐metathesis of erucic acid by [(PCy3)(η‐C‐C3H4N2Mes2)Cl2Ru = CHPh] (Grubbs second‐ generation catalyst) followed by catalytic hydrogenation and purification via the ester yields 1,26‐hexacosanedioate (>99% purity). Polyesterification with 1,26‐hexacosanediol, generated from the diester, affords polyester‐26,26, which features a Tm of 114 °C (Tc = 92 °C, ΔHm = 160 J g−1). Ultralong‐chain model polyesters‐38,23 (Tm = 109 °C) and −44,23 (Tm = 111 °C), generated via multistep procedures including acyclic diene metathesis polymerization, underline that melting points of such aliphatic polyesters do not gradually increase with methylene sequence chain length. Available data suggest that to mimic linear polyethylenes thermal properties, even longer sequences, amounting to at least four times a fatty acid chain, fully incorporated in a linear fashion are required.
Proteomics analysis of tumor microenvironment: Implications of metabolic and oxidative stresses in tumorigenesis
Authors: Zhou Shengtao , Liu Rui , Yuan Kefei , Yi Tao , Zhao Xia , Huang Canhua , Wei Yuquan 
Published: November 2012

AbstractTumorigenesis is always concomitant with microenvironmental alterations. The tumor microenvironment is a heterogeneous and complex milieu, which exerts a variety of stresses on tumor cells for proliferation, survival, or death. Recently, accumulated evidence revealed that metabolic and oxidative stresses both play significant roles in tumor development and progression that converge on a common autophagic pathway. Tumor cells display increased metabolic autonomy, and the hallmark is the exploitation of aerobic glycolysis (termed Warburg effect), which increased glucose consumption and decreased oxidative phosphorylation to support growth and proliferation. This characteristic renders cancer cells more aggressive; they devour tremendous amounts of nutrients from microenvironment to result in an ever‐growing appetite for new tumor vessel formation and the release of more “waste,” including key determinants of cell fate like lactate and reactive oxygen species (ROS). The intracellular ROS level of cancer cells can also be modulated by a variety of stimuli in the tumor microenvironment, such as pro‐growth and pro‐inflammatory factors. The intracellular redox state serves as a double‐edged sword in tumor development and progression: ROS overproduction results in cytotoxic effects and might lead to apoptotic cell death, whereas certain level of ROS can act as a second‐messenger for regulation of such cellular processes as cell survival, proliferation, and metastasis. The molecular mechanisms for cancer cell responses to metabolic and oxidative stresses are complex and are likely to involve multiple molecules or signaling pathways. In addition, the expression and modification of these proteins after metabolic or oxidative stress challenge are diverse in different cancer cells and endow them with different functions. Therefore, MS‐based high‐throughput platforms, such as proteomics, are indispensable in the global analysis of cancer cell responses to metabolic and oxidative stress. Herein, we highlight recent advances in the understanding of the metabolic and oxidative stresses associated with tumor progression with proteomics‐based systems biology approaches. © 2012 Wiley Periodicals, Inc., Mass Spec Rev 32:267–311, 2013
Free hemiback flap with surgical delay for reconstruction of extensive soft tissue defect: A case report
Authors: Fujiwara Masao , Nagata Takeshi , Matsushita Yuki , Fukamizu Hidekazu 
Published: November 2012

AbstractA delay procedure allows for reliable tissue transfer in random pattern flaps and axial pattern flaps. However, delay procedures have not been studied in free flaps. In this report, we present a case involving the use of a free extended latissimus dorsi musculocutaneous flap (hemiback flap) that included half of the total back skin and was based on thoracodorsal vessels for reconstruction of an extensive soft tissue defect of the flank and waist. The flap was tailored in combination with a delay procedure. Intraoperative indocyanine green fluorescence angiography indicated profuse perfusion except for the most inferomedial part of the flap, which was discarded. The flap survived. A free hemiback flap may offer a valuable option for reconstruction of extensive soft tissue defects. To our knowledge, this is the first report to demonstrate a free flap made in combination with a delay procedure. © 2012 Wiley Periodicals, Inc. Microsurgery, 2013.
T2 relaxometry with indirect echo compensation from highly undersampled data
Authors: Huang Chuan , Bilgin Ali , Barr Tomoe , Altbach Maria I. 
Published: November 2012

PurposeTo develop an algorithm for fast and accurate T2 estimation from highly undersampled multi‐echo spin‐echo data.MethodsThe algorithm combines a model‐based reconstruction with a signal decay based on the slice‐resolved extended phase graph (SEPG) model with the goal of reconstructing T2 maps from highly undersampled radial multi‐echo spin‐echo data with indirect echo compensation. To avoid problems associated with the nonlinearity of the SEPG model, principal component decomposition is used to linearize the signal model. The proposed CUrve Reconstruction via principal component‐based Linearization with Indirect Echo compensation (CURLIE) algorithm is used to estimate T2 curves from highly undersampled data. T2 maps are obtained by fitting the curves to the SEPG model.ResultsResults on phantoms showed T2 biases (1.9% to 18.4%) when indirect echoes are not taken into account. The T2 biases were reduced (< 3.2%) when the CURLIE reconstruction was performed along with SEPG fitting even for high degrees of undersampling (4% sampled). Experiments in vivo for brain, liver, and heart followed the same trend as the phantoms.ConclusionThe CURLIE reconstruction combined with SEPG fitting enables accurate T2 estimation from highly undersampled multi‐echo spin‐echo radial data thus, yielding a fast T2 mapping method without errors caused by indirect echoes. Magn Reson Med, 70:1026–1037, 2013. © 2012 Wiley Periodicals, Inc.
Cobalt(III)‐complex‐mediated terpolymerization of CO2, styrene oxide, and epoxides with an electron‐donating group
Authors: Wu Guang‐Peng , Xu Peng‐Xiang , Zu Yu‐Ping , Ren Wei‐Min , Lu Xiao‐Bing 
Published: November 2012

AbstractTerpolymerizations of CO2, styrene oxide (SO), and epoxides with an electron‐donating group such as propylene oxide (PO) or cyclohexene oxide (CHO) were carried out by using Co(III)–salen complexes in the presence of an intra‐ or intermolecular nucleophilic cocatalyst. The resultant terpolymers have only one thermolysis peak and one glass transition temperature (Tg), which can be easily adjusted by controlling the proportion of styrene carbonate linkages. During the CO2/SO/PO terpolymerization, the monomer reactivity ratios (rSO = 0.18 and rPO = 2.25) evaluated by Fineman–Ross plot indicates a random distribution of the two kinds of carbonate units in the resultant polymer. Contrarily, the monomer reactivity ratios were found to be rSO = 0.48 and rCHO = 0.79 in the CO2/SO/CHO terpolymerization, indicating that an alternating nature of the two different carbonate units predominantly exists in the resultant polycarbonate. The regioselective ring opening of SO has a significant effect on the reactivities of both SO and CHO during the terpolymerization with CO2. The matched reactivity is contributed to the enhanced regioselective ring opening of SO, caused by the attack of the dissociating polymer carboxylate anion, bearing a cyclohexene carbonate end unit. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
Rigid‐plane phonons in layered crystals
Authors: Michel K. H. , Verberck B. 
Published: November 2012

AbstractThe determination of the layer number ${\cal N}$ in nanoscale thin layered crystals is a challenging problem of technological relevance. In addition to innovative experimental techniques, a thorough knowledge of the underlying lattice dynamics is required. Starting from phenomenological atomic interaction potentials we have carried out an analytical study of the low‐frequency optical phonon dispersions in layered crystals. At the gamma point of the two‐dimensional Brillouin zone the optical phonon frequencies correspond to rigid‐plane shearing and compression modes. We have investigated graphene multilayers (GML) and hexagonal boron‐nitride multilayers (BNML). The frequencies show a characteristic dependence on ${\cal N}$. The results which are represented in the form of fan diagrams are very similar for both materials. Due to charge neutrality within layers Coulomb forces play no role, only van der Waals forces between nearest neighbor layers are relevant. The theoretical results agree with recent low‐frequency Raman results on rigid‐layer modes [Tan et al., Nature Mater. 11, 294 (2012)] in GML and double‐resonant Raman scattering data on rigid‐layer compression modes [Herziger et al., Phys. Rev. B 85, 235447 (2012)] in GML.
Lithium fluoride crystal as a novel high dynamic neutron imaging detector with microns scale spatial resolution
Authors: Faenov Anatoly , Matsubayashi Masahito , Pikuz Tatiana , Fukuda Yuji , Kando Masaki , Yasuda Ryo , Iikura Hiroshi , Nojima Takehiro , Sakai Takuro , Shiozawa Masahiro , Kato Yoshiaki 
Published: November 2012

AbstractRecently, a new field of application of optically stimulated luminescence of color centers (CCs) in lithium fluoride (LiF) crystals was proposed – using them for high‐performance neutron imaging – and promising results were obtained (Matsubayashi et al., Nucl. Instrum. Methods A 622, 637 (2010) and Matsubayashi et al., Nucl. Instrum. Methods A 651, 90 (2011)). Here we present the overview of main findings, which clearly demonstrated that the LiF crystal performs efficiently as neutron imaging detector in areas, where a high spatial resolution with a high image gradation resolution is needed. It was shown that the obtained neutron images are almost free from granular noises, have spatial resolution of ∼ 6 μm, and have practically linear response with the dynamic range of at least 103. It was also found that the LiF crystal detector offers a fairly good sensitivity. Moreover, detailed evaluation using a standard sensitivity indicator for neutron radiography showed that two holes with less than 2% transmittance differences could be distinguished. Additionally, we recently demonstrated that the high resolution neutron imaging with LiF crystals could be useful for quantitative characterizations of neutron sources and electric devices, comprising of low‐Z elements, for example, such as fuel cells. All of this gives new opportunity for microns scale spatial resolution imaging by neutrons (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)