bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual Solvent Dependence of a Molecule‐Based FeII Macrocyclic Spin‐Crossover Complex
Authors: Wang Hongfeng , Sinito Chiara , Kaiba Abdellah , Costa José Sanchez , Desplanches Cédric , Dagault Philippe , Guionneau Philippe , Létard Jean‐François , Negrier Philippe , Mondieig Denise 
Published: August 2014

AbstractThis work illustrates in detail the reversible hydration–dehydration process of a molecule‐based material, which involves a drastic change of the switchable magnetic properties of the sample. Concretely, the complex [FeL222N3O2(CN)2]·H2O exhibits a spin crossover (SCO) accompanied by a change of the coordination number. The dehydration and rehydration of this SCO complex was carried out and monitored by different methods, which include X‐ray diffraction analysis. The corresponding samples display a thermal spin transition as well as a thermal quenching of the metastable high‐spin state at low temperature. In particular it was observed that the rehydrated material exhibits a particularly high temperature of relaxation, T(TIESST), of the metastable high‐spin state. On the other hand, it was shown that this compound exhibits a uncommon correlation between T(TIESST) and the thermal SCO, as compared with other spin‐crossover compounds that do not exhibit a change in coordination number.
Phosphate Diester Cleavage, DNA Interaction and Cytotoxic Activity of a Bimetallic Bis(1,4,7‐triazacyclononane) Zinc Complex
Authors: Montagner Diego , Gandin Valentina , Marzano Cristina , Erxleben Andrea 
Published: August 2014

AbstractInvited for the cover of this issue are researchers from the National University of Ireland, Galway, and the University of Padua, Italy. The cover image shows the X‐ray structure of the dinuclear bis(1,4,7‐triazacyclononane) zinc complex synthesized in this work. The complex converts supercoiled plasmid DNA into the nicked form at low micromolar concentration and shows promising in vitro antitumor activity against pancreatic and lung cancer cell lines.
Predicting the Intention to Use a Web‐Based Learning System: Perceived Content Quality, Anxiety, Perceived System Quality, Image, and the Technology Acceptance Model
Authors: Calisir Fethi , Altin Gumussoy Cigdem , Bayraktaroglu Ayse E. , Karaali Demet 
Published: August 2014

AbstractThe aim of this study is to determine the factors affecting blue‐collar workers’ intention to use a web‐based learning system in the preimplementation phase in the automotive industry. For that purpose an extended technology acceptance model (TAM) is proposed, which included factors such as image, perceived content quality, and perceived system quality as additions to the basic model. Data collected from 546 blue‐collar workers were used to test the proposed research model by using Linear Structural Relations software LISREL, Version 8.54. The findings of the study indicate that perceived usefulness is the strongest predictor of behavioral intention to use a web‐based learning system. In addition, a high proportion of perceived usefulness is explained by perceived content quality, and perceived ease of use is explained by perceived system quality and anxiety.
Extraversion Personality and Computer Game Play
Authors: Fang Xiaowen , Zhu Miaoqi , Chan Susy 
Published: August 2014

AbstractThis study explored the relationship between one of the personality traits, extraversion, and computer game play. Some interesting observations about extraversion scores and what game players played were made during an online survey on enjoyment of computer game play. On the basis of these observations, an exploratory study was designed and conducted to further explore in‐depth information that might help interpret the preliminary observations. Results from both the online survey and the exploratory study were analyzed and synthesized. A hypothesis was proposed and substantiated by both empirical observations and theory. The findings of this study will likely provide researchers with insights into designing games for special purposes, such as education and training.
Long‐term water budget imbalances and error sources for cold region drainage basins
Authors: Wang Shusen , Huang Jianliang , Yang Daqing , Pavlic Goran , Li Junhua 
Published: August 2014

AbstractThis study assessed the long‐term (1979–2008) water budget closures for 19 large cold region drainage basins in Canada using recently developed datasets for precipitation (P), land surface evapotranspiration and water surface evaporation, and observed streamflow. Total water storage (TWS) trends from the GRACE satellite observations were also used to assist the assessment. The objectives are to quantify the magnitudes and spatial patterns of the water budget imbalance (ε) and its source of errors for these cold region basins. Results showed that the water budget was closed within 10% of the P on average for all the basins. The ε showed a general pattern of positive values in the south and negative values in the north and mountainous regions over the country. Basins with large ε values were mostly found in the north. Uncertainties in the water budget variables, particularly P, were found to play a major role in the ε. Significant trends in TWS were found over 11 basins, which accounted for 31% of their ε on average. Improvements in the observation network, data quality assurance, and spatial models for P are critical for further improving the water budget closure for the cold region drainage basins. © 2014 Her Majesty the Queen in Right of Canada. Hydrological Processes. © John Wiley & Sons, Ltd.
FORWARD PROGRESS OF SCIENTIFIC INQUIRY INTO THE EARLY FATHER–CHILD RELATIONSHIP: INTRODUCTION TO THE SPECIAL ISSUE ON VERY YOUNG CHILDREN AND THEIR FATHERS
Authors: Bocknek Erika L. , Hossain Ziarat , Roggman Lori 
Published: August 2014

ABSTRACTResearch on fathering and the father–child relationship has made substantial progress in the most recent 15 years since the last special issue of the Infant Mental Health Journal on fathers and young children. This special issue on fathers and young children contains a series of papers exemplifying this progress, including advances in methodology—more direct assessment and more observational measures—in addition to the increasing dynamic complexity of the conceptual models used to study fathers, the diversity of fathers studied, and the growth of programs to support early father involvement. In assessing the current state of the field, special attention is given to contributions made by the papers contained in this special issue, and two critical areas for continued progress are addressed: (1) methodological and measurement development that specifically address fathers and fathering relationships and (2) cross‐cultural and ecologically valid research examining the diversity of models of fathering.
WORD RETRIEVAL LATENCIES AS A FUNCTION OF FREQUENCY AND AGE‐OF‐ACQUISITION PRIMING, REPEATED TRIALS, AND INDIVIDUAL DIFFERENCES
Authors: Carroll John B. 
Published: August 2014

ABSTRACTOver three immediately succeeding trials using different randomized orders of stimuli, 45 young adults, mostly males, named 50 pictures of objects, each as rapidly as possible; latencies were measured for each item. Fifteen of the subjects were tested in a control condition; before each of 5 blocks of 10 items in a trial, subjects in a second group (N = 15) were given information as to the word frequency (WF) level of the items' names, and a third group (N = 15) were given information as to the typical age of acquisition (AOA) level of the names, the pictures and names having been selected such that the WF and AOA levels had a correlation as low as possible. Under all conditions, the previous finding (Carroll & White, 1973a) that AOA was a stronger predictor of latencies than WF was confirmed. Scores on a psychometric test of speed of picture naming were highly correlated (within‐group r = .69) with mean reciprocals of latencies in the experimental picture‐naming situation. “Priming” of responses by prior information on AOA was more facilitative than WF information, but as compared to the control condition such information had a retarding effect. Speed of naming improved over trials in all conditions, but AOA levels of the names, as well as the lags between successive presentations of an item, affected the amount of improvement in a complex manner. It is suggested that retrieval of an item from TLTM (“truly long‐term memory”) places it in an immediate memory buffer.
ASSIGNMENT TO TREATMENT GROUP ON THE BASIS OF A COVARIATE
Authors: Rubin Donald B. 
Published: August 2014

ABSTRACTWhen assignment to treatment group is made solely on the basis of the value of a covariate, X, effort should be concentrated on estimating the conditional expectations of the dependent variable Y given X in the treatment and control groups. One then averages the difference between these conditional expectations over the distribution of X in the relevant population. There is no need for concern about “other” sources of bias, e.g., unreliability of X, unmeasured background variables. If the conditional expectations are parallel and linear, the proper regression adjustment is the simple covariance adjustment. However, since the resulting estimates may be somewhat sensitive to the adequacy of the underlying model, it is wise to search for non‐parallelism and non‐linearity in these conditional expectations. Blocking on the values of X is also appropriate, although the resulting estimates may be somewhat sensitive to the coarseness of the blocking employed.
Renal denervation using focused infrared fiber lasers: A potential treatment for hypertension
Authors: Alexander Vinay V. , Shi Zhennan , Iftekher Fariha , Welsh Michael J. , Gurm Hitinder S. , Rising Gail , Yanovich Amber , Walacavage Kim , Islam Mohammed N. 
Published: August 2014

Background and ObjectiveRenal denervation has recently become of great interest as a potential treatment for resistant hypertension. Denervation techniques using radio frequency (RF) or ultrasound energy sources have already been explored in literature. In this study, we investigate the use of lasers as a potential energy source for renal denervation. In vitro studies are performed in porcine/ovine renal arteries with focused laser beams at 980 nm, 1210 nm, and 1700 nm to study the ability to damage renal nerves without causing injury to non‐target tissue structures like the endothelium. Then, a 980 nm laser catheter prototype is built and used to demonstrate in vivo renal denervation in ovine renal arteries.Subjects and MethodsThis study utilizes fiber coupled infrared lasers at 980 nm, 1210 nm, and 1700 nm. In vitro laser denervation studies at 980 nm are performed in both porcine and ovine renal arteries to study the ability of focused laser beams to damage renal nerves without injuring the endothelium. In vitro studies using lasers close to the lipid absorption lines at 1210 nm and 1700 nm are also performed in porcine renal arteries to study the possibility of selectively damaging the renal nerves by targeting the lipid myelin sheaths surrounding the nerves. Then, a laser catheter prototype is designed and built for in vivo renal denervation in ovine renal arteries using the 980 nm laser (powers ranging from 2 to 4 W, 5 seconds per exposure). Histochemical evaluations of the frozen sections are performed using methylthiazolyldiphenyl‐tetrazolium bromide (MTT) assay.ResultsHistochemical analysis of in vitro laser treatments at 980 nm in porcine and ovine renal arteries show clear evidence of laser‐induced renal nerve damage without injury to the endothelium and part of the media. No evidence of selective nerve damage is observed using the 1210 nm and 1700 nm lasers with the current treatment parameters. Histochemical analysis of in vivo laser treatments in ovine renal arteries using a focused 980 nm laser show clear evidence of renal nerve damage with depths of damage extending > 1.5 mm from the artery wall. Sections with laser‐induced damage to the media/adventitia at depths of > 1 mm without injury to the endothelium are also observed.ConclusionsWe demonstrate the use of focused lasers as an attractive energy source for causing renal nerve damage without injury to the artery wall and thus, may have potential therapeutic applications for conditions such as resistant hypertension, where renal denervation has been shown to be a promising form of treatment. Lasers Surg. Med. 46:689–702, 2014. © 2014 Wiley Periodicals, Inc.
In‐Solution Structural Considerations by 1H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs
Authors: Catenacci Laura , Mandracchia Delia , Sorrenti Milena , Colombo Lino , Serra Massimo , Tripodo Giuseppe 
Published: August 2014

1H NMR is a suitable method to clarify the kind of interactions leading to the self‐assembly of amphiphilic polymers. This work shows, from 1H NMR studies performed in solution, that the self‐assembly ability of the synthesized Inulin‐d‐α‐tocopherol succinate (INVITE) amphiphilic polymers, can be addressed to specific π–π interactions between the aromatic regions of d‐α‐tocopherol. This result suggests the use of INVITE systems for the preferential loading of aromatic group bearing drugs such as curcumin. The preparation conditions, effect of drug loading, and lyophilization on the INVITE systems are evaluated by DSC and thermogravimetric analysis (TGA) analysis to assess whether common pharmaceutical processes could influence the physical properties of the amphiphilic polymers, such as crystallinity, glass‐transition temperature or thermal degradation, to predict the physical stability of the systems upon administration. Furthermore, the size stability of the micelle systems up to 60 days is monitored to assess the feasibility of the INVITE micelles’ long‐term storage upon reconstitution with water.
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A system biology study of BALF from patients affected by idiopathic pulmonary fibrosis (IPF) and healthy controls
Authors: Landi Claudia , Bargagli Elena , Carleo Alfonso , Bianchi Laura , Gagliardi Assunta , Prasse Antje , Perari Maria G. , Refini Rosa M. , Bini Luca , Rottoli Paola 
Published: August 2014

BackgroundIdiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by progressive loss of the alveolar integrity, recruitment, and activation of myofibroblast, and excessive collagen deposition that resulted in loss of parenchymal architecture and lung function. Although etiology is unknown, major risk factor of disease development is represented by cigarette smoke or exposure to dust.AimsAim of this proteomic study was to compare broncho alveolar lavage fluid protein profiles of IPF patients, never‐smoker healthy control (nonsmoker control) and smoker control subjects in order to investigate proteins potentially related to disease progression and pathogenesis.MethodsBroncho alveolar lavage fluid samples were resolved using 2D‐PAGE and the differentially expressed proteins were identified by MS. The performed PCA statistically proved the correlation existing between differentially expressed spots in the three groups. Functional analysis of the identified proteins was performed by pathway and enrichment analysis by MetaCore and Database for Annotation, Visualization and Integrated Discovery.ResultsInterestingly, transcriptional factors NF‐kB, PPARγ, and c‐myc emerged as well as a group of functional hubs. Enrichment analysis suggested that Gene Ontology (GO) process networks and pathway maps involved in IPF included angiotensin system maturation, renin‐angiotensin‐aldosteron system, heme metabolism, coagulation system, response to hypoxia, oxidative stress, and iron transport.ConclusionIn conclusion, the combination of proteomic data with system biology platforms allowed us to amplify the information obtained processing the results and indicated the principal pathways involved. These information can point to potential biomarkers and new therapeutic targets opening the way for further analysis.
Rheological Characterization of Metalized and Non‐Metalized Ethanol Gel Propellants
Authors: Jyoti Botchu. V. S. , Baek Seung Wook 
Published: August 2014

AbstractThe gellation of metalized and non‐metalized ethanol with a methylcellulose gelling agent and its effect on the rheological properties (flow and dynamic study) of these gels is reported herein. The rheological study shows that increasing the shear rate reduces the apparent viscosity for a given yield stress (for a shear rate range of 1 to 12 s−1) for both shear rate ranges (1 to 12 and 1 to 1000 s−1) covered in present experiment. The gellant and metal particle concentrations significantly influence the gel apparent viscosity. Distinct changes in thixotropic behavior were observed, while decreasing the concentration of MC gellant and Al metal particles in the ethanol gels. The dynamic study showed that all of the linear viscoelastic regions (LVE) of the gel samples were independent of strain percentage (1 to 10). The G′ values depended on the frequency and exceeded the G′′ values, which indicated a gel‐like highly structured material. The tanδ values showed that all of the ethanol gels were elastic and weak physical gels with a high degree of cross‐linking.
In‐situ Remediation of Hydrogen Fluoride During a Detonation Event
Authors: Caflin Kelley Corinne , Anderson Paul E. 
Published: August 2014

AbstractHydrogen fluoride (HF) is a known product from the combustion or detonation of explosives formulated with fluoropolymer binder systems. This presents the user with elevated risk levels during unintended combustion events or detonations in confined situations. In an effort to remediate the production of HF, calcium disilicide (CaSi2) was added to explosive formulations and the amount of HF formed was monitored. Viton A/calcium disilicide mixtures were made and the thermal decomposition characteristics studied using thermal gravimetric/differential thermal analysis (TG/DTA). The activation energy ranged from 145–190 kJ mol−1, indicative of CF scission in the Viton A binder prior to calcium fluoride formation. An energetic formulation was prepared which consisted of approximately a 5/3 mass ratio of Viton A/CaSi2. Combustion calorimetry in oxygen and air, and subsequent analysis of the residues using X‐ray diffraction (XRD) showed evidence of calcium fluoride (CaF2) formation. The decrease in HF formation was determined by trapping off gases and subsequent analysis in anion exchange chromatography of combustion and detonation products. Upon introduction of calcium disilicide into the formulation, a small decrease in HF formation was observed along with appearance of calcium fluoride and free Si in the residue. Such products are consistent with the mechanism following a general decomposition path of 2F−+CaSi2→CaF2+2Si. Under detonation conditions, the decomposition path followed nearly the same route with a net ca. 30 % decrease in HF formation, but with a portion of the silicon oxidizing slightly further to SiO2.
ERG expression in prostate cancer: The prognostic paradox
Authors: Taris Michael , Irani Jacques , Blanchet Pascal , Multigner Luc , Cathelineau Xavier , Fromont Gaelle 
Published: August 2014

BACKGROUNDTMPRSS2/ERG fusion resulting in ERG overexpression occurs in 30 to 50% of prostate cancer (PCa) in Caucasian patients, but its prognostic relevance remains controversial. In the present study, we investigated ERG expression in all stages of PCa progression, and evaluated the prognostic impact of ERG status in clinically localized PCa (CLC) and in castration resistant disease (CRPC).METHODSERG and AR expressions were evaluated by immunohistochemistry on tissue microarrays containing samples of high grade PIN (n = 57), CLC surgically treated (n = 299, including 185 Caucasians and 114 African‐Caribbeans), metastases (n = 17), and CRPC (n = 41).RESULTSIn Caucasians, ERG expression significantly increased from high grade PIN (17.5%) to pT2 (27%) and pT3 CLC (43%), then to metastases (53%). In CLC, stainings for ERG and AR were correlated, and ERG expression was less frequent in African–Caribbeans compared to Caucasians (11.5% vs. 33%). In Caucasians CLC, ERG was associated with longer recurrence free survival, after adjusting for classical prognostic markers. In CRPC, ERG was expressed in 29% of cases, and was associated with a longer overall survival.CONCLUSIONSOur results confirm that ERG expression is less frequent in PCa from patients of African descent. Although ERG expression increases during PCa natural history, positive ERG status is associated with better outcome in both CLC and CRPC. This paradox could be explained in part by the fact that ERG expression is AR dependant, then ERG positive cancers are likely to progress in a rich androgen environment, with a better response to androgen suppression. Prostate 74:1481–1487, 2014. © 2014 Wiley Periodicals, Inc.
Careers on the Move: International Doctoral Students at an Elite British University
Authors: Pásztor Adél 
Published: August 2014

AbstractInternational student mobility, especially at doctoral level, is a largely under‐researched component of international migration. This is in stark contrast with the case of credit mobility where much research has been undertaken on Erasmus students. The aim of this paper is to remedy the situation by focusing on international doctoral students who chose to study at an elite higher education institution in the UK. By analysing the role of – local, national and international – schemes of funding in shaping individual mobility decisions, the author argues against the portrayal of international students as ‘rational decision makers’ in favour of a more contextualised approach to mapping the graduate student migratory phenomenon. By contrasting the ‘entry channels’ of students with their future plans – in terms of the nature of future career and geographic location – the author challenges the assumption that internationally mobile students are coming with the intention of settling down in their study destination. The study cannot uphold the view of international students as a ‘migratory elite’ either; although some postgraduate students are indeed from more privileged backgrounds, many individuals undertake international doctoral mobility with the explicit aim of capital accumulation. Last but not least, the paper strongly argues for abandoning the term ‘spontaneous mobility’ in student mobility research because a significant proportion of degree mobility does not occur spontaneously but is a result of organised schemes of funding. Copyright © 2014 John Wiley & Sons, Ltd.