bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Does It Mean to Successfully Age?: Multinational Study of Older Adults’ Perceptions
Authors: Burton Elissa , Teater Barbra , Chonody Jill , Alford Sabretta 
Published: August 2024

Abstract

Background and Objectives
Successful aging is a mainstay of the gerontological literature, but it is not without criticism, including the often-limited way that it is studied and measured as well as the exclusion of older adults’ voices in its formulation and understanding. This study sought to address these issues through a qualitative investigation across multiple countries.

Research Design and Methods
This was a mixed-methods, cross-sectional, exploratory study using an online survey. Nations that received the survey included Australia, New Zealand, the United Kingdom, Ireland, Canada, and the Unites States. Participants aged 65 and older were asked to describe what successful aging means to them in an open-ended survey item. Summative content analysis was utilized to examine the responses.

Results
Successful aging was defined by 1,994 participants, and 6 themes along with 20 subthemes were found. In contrast to conception that successful aging is solely or predominantly related to the absence of disease and decline, the most prominent theme in this study was “active, independent, and engaged” as the hallmark of success.

Discussion and Implications
Although health and health maintenance were present in other themes, these findings support a multidimensional definition of successful aging that promotes the perspectives of older people. Future research should seek to further investigate the ways in which person-in-environment factors influence definitions of successful aging, including culture, gender and gender identity, race and ethnicity, and socioeconomic background.
Ethylene in fruits: beyond ripening control
Authors: Huang Wei , Tan Cong , Guo Hongwei 
Published: August 2024

Abstract
Fruits are a rich source of nutrients, minerals, and dietary fibers for both humans and animals. While the gaseous phytohormone ethylene is well-known for its role in controlling fruit ripening, there is growing evidence that ethylene also plays crucial roles in regulating other developmental processes of fruits, such as sex determination, fruit set, and fruit growth. In this review, we aim to revisit these findings from various species like cucumber, melon, tomato, rice, maize, and more. These studies not only enhance our understanding of ethylene’s function in fruits but also highlight the potential for manipulating ethylene to improve crops. Furthermore, we discuss recent studies that show the ethylene precursor ACC (1-AMINOCYCLOPROPANE-1-CARBOXYLATE), and the ethylene signaling components EIN2 (ETHYLENE INSENSITIVE2) and EIN3 (ETHYLENE INSENSITIVE3) have ethylene-independent function in specific conditions. This phenomenon, combined with findings of dosage-dependent ethylene functions in certain conditions, highlights the importance of analyzing mutants with completely blocked ethylene pathways in different species at specific developmental stages and tissue types. Overall, this review offers a timely and essential summary of ethylene’s role in sex determination, fruit formation, and fruit growth, which could be beneficial for horticulture crop breeding.
Compatibility of medication admixtures in continuous subcutaneous infusions: prioritizing laboratory testing for common combinations
Authors: Leong Marco Cheok In , Michael Natasha , Wojnar Robert 
Published: August 2024

Abstract

Objectives
Continuous subcutaneous infusions (CSCIs) are indicated as an alternative therapy when the oral route is not viable. However, despite their widespread use in palliative care, the evidence for admixture compatibility remains a limitation. It is estimated that a significant number of admixtures used in practice are not supported by laboratory studies, which may lead to suboptimal clinical outcomes. The study aimed to determine the frequency of admixtures used in clinical practice without compatibility data generated by laboratory studies, and thereby identifying the most commonly prescribed admixtures that require laboratory data, which can help to guide the prioritization of future testing.

Methods
This study was conducted across five palliative care services (three inpatients and two communities) in Victoria, Australia between May and July 2021. Electronic or paper medication charts of CSCIs were reviewed across all participating sites for all infusions administered. Data collected included medication combinations, dose, diluent, final volume, duration of infusion, reports of infusion-related reactions, and observed incompatibility.

Key findings
A total of 616 infusions containing two to three medications were assessed. Only 60% of these infusions were validated by laboratory data. Eleven most commonly prescribed admixtures with no laboratory compatibility data were identified over the 3-month period.

Conclusion
Laboratory testing for the identified admixtures should be advocated to promote the safe and effective use of these medications.
The relationship between person-centred care and well-being and satisfaction with care of patients living with obesity
Authors: Crompvoets Paige I , Nieboer Anna P , van Rossum Elisabeth F. C , Cramm Jane M 
Published: August 2024

Abstract
Person-centred care (PCC) is associated with improved patient well-being and higher levels of satisfaction with care but its impact on individuals living with obesity is not well-established. The main aim of this study was to assess the relationship between PCC and the physical and social well-being of patients living with obesity, as well as their satisfaction with care. This study is based on a cross-sectional, web-based survey administered among a representative panel of Dutch individuals living with obesity. The primary outcomes were physical and social well-being and satisfaction with care. The primary exposure was a rating of overall PCC, encompassing its eight dimensions. In addition, covariates considered in the analyses included sex, age, marital status, education level, body mass index, and chronic illness. The data from a total of 590 participants were analysed using descriptive statistics, correlation analyses, and multiple regression analyses. Among PCC dimensions, participants rated ‘access to care’ the highest (M 4.1, SD 0.6), while ‘coordination of care’ (M 3.5, SD 0.8) was rated lower than all other dimensions. Participants’ overall PCC ratings were positively correlated with their physical (r = 0.255, P &lt; .001) and social well-being (r = 0.289, P &lt; .001) and their satisfaction with care (r = 0.788, P &lt; .001), as were the separate dimension scores. After controlling for sex, age, marital status, education level, body mass index, and chronic illness in the regression analyses, participants’ overall PCC ratings were positively related to their physical (β = 0.24, P &lt; .001) and social well-being (β = 0.26, P &lt; .001), and satisfaction with care (β = 0.79, P &lt; .001). PCC holds promise for improved outcomes among patients living with obesity, both in terms of physical and social well-being, as well as satisfaction with care. This is an important finding, particularly when considering the profound physical, social, and psychological consequences associated with obesity. In addition to highlighting the potential benefits of PCC in the healthcare of individuals living with obesity, the findings offer valuable insights into strategies for further refining the provision of PCC to meet the specific needs of these patients.
Jumping Performance and Behavior of the Globular Springtail Dicyrtomina minuta
Authors: Smith A A , Harrison J S 
Published: August 2024

Synopsis
Springtails are among the most abundant arthropods on earth and they exhibit unique latch-mediated spring-actuated jumping behaviors and anatomical systems. Despite this, springtail jumps have not been well described, especially for those with a globular body plan. Here, we provide a complete description and visualization of jumping in the globular springtail Dicyrtomina minuta. A furca-powered jump results in an average take-off velocity of 1 ms−1 in 1.7 ms, with a fastest acceleration to liftoff of 1938 ms−2. All jumps involve rapid backwards body rotation throughout, rotating on average at 282.2 Hz with a peak rate of 368.7 Hz. Despite body lengths of 1–2 mm, jumping resulted in a backwards trajectory traveling up to 102 mm in horizontal distance and 62 mm in vertical. Escape jumps in response to posterior stimulation did not elicit forward-facing jumps, suggesting that D. minuta is incapable of directing a jump off a flat surface within the 90° heading directly in front of them. Finally, two landing strategies were observed: collophore-anchoring, which allows for an immediate arrest and recovery, and uncontrolled landings where the springtail chaotically tumbles. In comparison to other fast jumping arthropods, linear performance measures globular springtail jumps place them between other systems like fleas and froghoppers. However, in angular body rotation, globular springtails like D. minuta surpass all other animal systems. Given the extraordinary performance measures, unique behavioral responses, and understudied nature of these species, globular springtails present promising opportunities for further description and comparison.
Chinese Firms in the US–China Trade War: Decoupling through Reshoring?
Authors: Zeng Ka , Kim Soo Yeon 
Published: August 2024

Abstract
This paper leverages firm-level data to examine the impact of the US–China trade war on the greenfield investment of Chinese investors. Our research yields a few interesting findings. Importantly, our longitudinal analysis of Chinese greenfield investment projects yields evidence that the tariffs have dampened overall Chinese investment. Further analyses for different world regions indicate that while the tariffs have generally had a chilling effect on Chinese investment in most world regions, they may have prompted Chinese investors to engage in “tariff-jumping” in the United States. Our analysis further shows that the trade war may have incentivized Chinese investors to increasingly invest in countries with good political ties with Beijing, presumably as a buffer against potential downturns in bilateral relations. It may also have contributed, at least in part, to a reduced willingness by Chinese state-owned enterprises to engage in overseas investment. However, we found no evidence that the tariffs have led to a perceptible shift in China's investment flows toward BRI countries. Overall, these findings help to illuminate the extent to which policies of “decoupling” may have induced shifts in Chinese investors’ investment patterns, at least in the short-run.
Exploring the Interactive Impacts of Citronellol, Thymol, and Trans-Cinnamaldehyde in Broilers: Moving towards an Improved Performance, Immunity, Gastrointestinal Integrity, and Clostridium perfringens Resistance
Authors: Abd El-Hamid Marwa I , El-Malt Rania M S , Al-Khalaifah H S , Al-Nasser Afaf , Elazab Sara T , Basiony Asmaa , Ali Amira M , Mohamed Dalia I , Nassan Mohamed A , Ibrahim Doaa 
Published: August 2024

Abstract

Aims
This study aimed to explore the effectiveness of dietary citronellol, thymol, and trans-cinnamaldehyde (CTC) essential oils blend on broilers` growth performance, immunity, intestinal microbial count, gut integrity, and resistance against Clostridium perfringens utilizing the necrotic enteritis (NE) challenge model.

Methods and results
A total of 200 Ross 308 male broiler chicks received either a control diet or diet supplemented with three graded levels of CTC blend including 300, 600, and 900 mg of CTC blend/Kg diet and experimentally infected with C. perfringens strain at 23 days of age. Herein, dietary CTC blend fortifications significantly improved the broilers` growth performance, which was supported by upregulating the expression levels of MUC-2, occludin, and JAM-2 genes. Moreover, dietary CTC blend inclusion significantly enhanced the levels of blood phagocytic percentage and serum IgA, IgG, and MPO, and reduced the values of serum CRP, and NO at 5 days pre-infection, 10-, and 15 days post-infection (dpi) with C. perfringens. At 15 dpi, CTC blend inclusion significantly reduced the intestinal digesta pH, coliforms and C. perfringens loads, and the expression levels of genes related to C. perfringens virulence (cpe, cnaA, and nanI), proinflammatory cytokines (IL-1β and TNF-α), and chemokines (CCL20), in addition to increasing the count of beneficial total Lactobacillus and total aerobic bacteria, and the expression levels of genes related to anti-inflammatory cytokines (IL-10) and chemokines (AvBD6, and AvBD612).

Conclusion
Our results point to the growth-provoking, immunostimulant, antibacterial, anti-inflammatory, and antivirulence characteristics of the CTC blend, which improves the broilers' resistance to C. perfringens and ameliorates the negative impacts of NE.
Overwintering potential of the Mediterranean fruit fly (Diptera: Tephritidae) in Austria
Authors: Wernicke Matthias , Egartner Alois , Blümel Sylvia , Moraiti Cleopatra A , Papadopoulos Nikos T 
Published: August 2024

Abstract
The Mediterranean fruit fly (medfly), Ceratitis capitata (Wiedemann), one of the most important invasive pests of fresh fruits and vegetables from the coastal Mediterranean habitats, is expanding its current geographic distribution to cooler more temperate areas of Europe. Every year since 2010 the fly is detected in the area of Vienna, Austria. However, whether it can establish permanent populations is not known. In this current paper, the capacity of C. capitata to overwinter in Vienna, Austria (48.1° northern latitude) was studied over 2 consecutive winter seasons (2020–2022). Overwintering trials with different life stages (larva, pupa, and adult) of C. capitata were performed in the open field and in the protected environment of a basement without a heating system. Control flies were kept under constant conditions in a climate chamber (25 °C, 60% RH, 14:10 L:D). Our data showed that no life stage of the Mediterranean fruit fly was able to survive the Austrian winter in the open field. However, in the protected environment C. capitata outlived the winter months in all studied life stages at least in small numbers and several surviving females were able to lay eggs at the time of the following fruiting season. Implications of these findings for the ongoing geographic range expansion of the pest in temperate European countries are discussed.
Genetic background affects neutrophil activity and determines the severity of autoinflammatory osteomyelitis in mice
Authors: Pavliuchenko Nataliia , Kuzmina Maria , Danek Petr , Spoutil Frantisek , Prochazka Jan , Skopcova Tereza , Pokorna Jana , Sedlacek Radislav , Alberich-Jorda Meritxell , Brdicka Tomas 
Published: August 2024

Abstract
The knowledge about the contribution of the innate immune system to health and disease is expanding. However, to obtain reliable results, it is critical to select appropriate mouse models for in vivo studies. Data on genetic and phenotypic changes associated with different mouse strains can assist in this task. Such data can also facilitate our understanding of how specific polymorphisms and genetic alterations affect gene function, phenotypes, and disease outcomes. Extensive information is available on genetic changes in all major mouse strains. However, comparatively little is known about their impact on immune response and, in particular, on innate immunity. Here, we analyzed a mouse model of chronic multifocal osteomyelitis, an autoinflammatory disease driven exclusively by the innate immune system, which is caused by an inactivating mutation in the Pstpip2 gene. We investigated how the genetic background of BALB/c, C57BL/6J, and C57BL/6NCrl strains alters the molecular mechanisms controlling disease progression. While all mice developed the disease, symptoms were significantly milder in BALB/c and partially also in C57BL/6J when compared to C57BL/6NCrl. Disease severity correlated with the number of infiltrating neutrophils and monocytes and with the production of chemokines attracting these cells to the site of inflammation. It also correlated with increased expression of genes associated with autoinflammation, rheumatoid arthritis, neutrophil activation, and degranulation, resulting in altered neutrophil activation in vivo. Together, our data demonstrate striking effects of genetic background on multiple parameters of neutrophil function and activity influencing the onset and course of chronic multifocal osteomyelitis.
Differential changes in mast cells with food reintroduction in children with eosinophilic esophagitis
Authors: Ebanks Andrew , Wang Ming-Yu , Hoffmann Natalie , Wershil Barry K , Wechsler Joshua B 
Published: August 2024

Abstract
Intraepithelial mast cells (MCs) are increased in eosinophilic esophagitis (EoE) and reduced with elimination of dietary antigens. Single food reintroduction can identify triggers of eosinophilia; however, the extent to which specific foods trigger intraepithelial mastocytosis remains unknown. We hypothesized that specific foods drive different degrees of MC inflammation. We previously reported a prospective pediatric EoE cohort treated with a 4-food elimination diet (4FED) with removal of soy, egg, wheat, and milk. We retrieved unstained slides in which baseline, 4FED, and post-4FED diet reintroduction time points were available. Slides were stained with tryptase, and intraepithelial MCs were counted. Comparisons were made by stratifying patients by eosinophilia, basal cell hyperplasia (BCH), endoscopic abnormalities, and symptoms. Pearson correlation was assessed for MCs with eosinophilic, endoscopic, and BCH severity; symptoms; and a novel mucosal activity score combining endoscopic and histologic structural severity. Slides were available from 37 patients with at least 1 food reintroduced. MCs were significantly reduced with 4FED. Wheat led to increased intraepithelial MCs in the upper esophagus and with food-induced eosinophilia, while milk led to significantly increased MCs in the upper and lower esophagus and was significantly associated with patients with food-triggered eosinophilia, endoscopic abnormalities, BCH, and symptoms. MCs best correlated with the mucosal activity score during milk reintroduction. In children with EoE, MCs are reduced with 4FED. During milk reintroduction, significant increases in MCs were observed with all metrics of inflammation along with moderate correlation with structural mucosal activity that was not seen with other foods. This suggests that milk exerts unique effects either directly or indirectly on MCs in the esophagus in EoE patients.
Bison mother–offspring acoustic communication
Authors: Clarke Jennifer A 
Published: August 2024

Abstract
Mother–offspring communication is especially crucial for social species in order to synchronize activities essential for early survival including nursing, resting, maintaining proximity during group movements between food or water sources, and locating one another if separated in a large social group. One of the most social ungulate species in North America is the American Bison (Bison bison), formerly known as buffalo. Adult female bison associate with their young for over a year and communication between mother and offspring is likely essential for establishing and maintaining a bond upon which the life of a calf depends. One goal of this study was to quantify and compare the acoustic form of vocalizations of adult female, subadult, and calf bison and to determine how age classes differed in call structure. The other goal was to identify the contexts in which bison vocalized. Vocalizations of 101 bison (53 adult females, 15 subadults, 33 calves) in a semi-free-ranging herd in Montana were analyzed and found to be pulsatile sounds, unlike vocalizations of bison bulls or domestic cows and calves. Vocalizations of bison cows, subadults, and calves differed significantly in total duration, numbers of pulses, pulse duration, and pulse rate. Seven distinct call contexts were identified. The majority of calls were “moving-on calls” (39%), when a cow called and her calf ran to her side and the 2 moved on together, and “contact calls” (21%) when a cow called and her calf called back but neither changed their location. “Imprinting calls” and “nursing calls” were also identified. Mother–offspring acoustic communication in bison appears especially critical for coordinating movements. Understanding the role of acoustic communication in maintaining the bond between bison mothers and their offspring can contribute to the humane management and welfare of this iconic species.
Cost trends of metastatic renal cell carcinoma therapy: the impact of oral anticancer agents and immunotherapy
Authors: Forman Rebecca , Long Jessica B , Westvold Sarah J , Agnish Khushi , Mcmanus Hannah D , Leapman Michael S , Hurwitz Michael E , Spees Lisa P , Wheeler Stephanie B , Gross Cary P , Dinan Michaela A 
Published: August 2024

Abstract

Background
Immunotherapy (IO) and oral anticancer agents (OAA) have improved outcomes for metastatic renal cell carcinoma (mRCC), but there is a need to understand real-world costs from the perspective of payers and patients.

Methods
We used retrospective fee-for-service Medicare 100% claims data to study patients diagnosed with mRCC in 2015-2019. We identified initial treatment type and costs (the year after diagnosis) and analyzed differences in monthly and 12-month costs over time and between OAA, IO, and combination groups and the association between Out-Of-Pocket (OOP) costs and adherence.

Results
We identified 15 407 patients with mRCC (61% male; 85% non-Hispanic White). A total of 6196 received OAA, IO, or combination OAA/IO as initial treatment. OAA use decreased (from 31% to 11%) with a simultaneous rise in patients receiving IO (3% to 26%) or combination IO/OAA therapy (1% to 11%). Medicare payments for all patients with mRCC increased by 41%, from $60 320 (95% confidence interval = 58 260 to 62 380) in 2015 to $85 130 (95% confidence interval = 82 630 to 87 630) in 2019. Payments increased in patients who received OAA, IO, or combination OAA/IO but were stable in those with other/no treatment. Initial higher OOP responsibility ($200-$1000) was associated with 13% decrease in percent days covered in patients receiving OAA in the first 90 days of treatment, compared with those whose OOP responsibility was less than $200.

Conclusion
From 2015 to 2019, costs for Medicare patients with mRCC rose substantially due to more patients receiving IO or IO/OAA combined therapy and increases in costs among those receiving those therapies. Increased OOP costs was associated with decreased adherence.
Migrant necropolitics in No Man’s Land camps
Authors: Pasha Suraina 
Published: August 2024

Abstract
Through genealogical explorations of the understudied No Man’s Land camps at Rukban and Zero Point, this paper aims to contribute a decolonial, South-centric perspective to critical refugee politics literature. The two No Man’s Land camps are conceptualized here as necropolitical spaces of migrant abandonment and containment, where States effectively determine ‘who may live and who must die’ through their violent expulsion of unwanted populations, securitized border policies and restrictions on life-saving aid. Despite their immobilization, the paper highlights how the displaced migrants formed self-government and engaged in claim-making for aid, rights, and homeland political change, thus transforming the death worlds of the No Man’s Land camps into spaces of vibrant political contention. This necropolitical resistance comes with the risk of death or redisplacement, but it provides tantalizing clues of the possibilities of living, even if only momentarily, beyond the law and the State.