bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hashimoto’s Thyroiditis as a Risk Factor of Papillary Thyroid Cancer May Improve Cancer Prognosis
Authors: Lun Yu , Wu Xiaoyu , Xia Qian , Han Yanshuo , Zhang Xiaoyu , Liu Zhimin , Wang Fengyi , Duan Zhiquan , Xin Shijie , Zhang Jian 
Published: January 2013

ObjectiveHashimoto’s thyroiditis (HT) has been associated with an elevated risk of papillary thyroid cancer (PTC). To investigate the possible influence of HT on the prognosis of PTC patients, we assessed the related clinical factors linking these conditions, especially serum thyroid‐stimulating hormone (TSH) concentration.Study DesignCase‐control study.SettingThe First Hospital of China Medical University.Subjects and MethodsThe demographic and histological characteristics of 2478 patients who underwent thyroidectomy at our center from 2004 to 2012 were analyzed.ResultsCompared with patients with benign thyroid nodular disease, patients with PTC showed a significantly higher prevalence of HT (18.8% vs 7.2%, P <. 001), mean TSH concentrations (2.02 ± 1.76 vs 1.46 ± 1.21 mIU/L, P <. 001), and positivity rates for anti–thyroglobulin antibodies (TGAB; 40.0% vs 20.4%, P <. 001) and anti–thyroid peroxidase antibodies (24.8% vs 12.5%, P <. 001). These differences remained after excluding all HT patients. The TSH concentrations were significantly higher in PTC patients with HT than in those without HT (2.54 ± 2.06 vs 1.90 ± 1.66 mIU/L, P =. 001). Patients with PTC and HT were younger, with a female predominance, and had smaller sized tumors with less advanced TNM stage compared with those without HT, indicating a better prognosis. Multivariate analysis showed that HT, higher TSH concentration, male sex, and TGAB positivity were independent risk factors for PTC development.ConclusionHistologically confirmed HT is associated with a significantly higher risk of PTC, due primarily to the higher serum TSH concentrations resulting from the tendency to hypothyroidism in HT. Autoimmunity is another independent risk factor for PTC but may be associated with a better prognosis.
The crystal structure of kraisslite, [4]Zn3(Mn, Mg)25(Fe3+,Al)(As3+O3)2[(Si,As5+)O4]10(OH)16, from the Sterling Hill mine, Ogdensburg, Sussex County, New Jersey,
USA
Authors: Cooper M. A. , Hawthorne F. C. 
Published: January 2013

AbstractThe crystal structure of kraisslite, orthorhombic (pseudo-hexagonal), a = 8.1821(1), b = 14.1946(3), c = 43.9103(8) Å, V = 5099.8(2) Å3, Z = 4 and dcalc = 4.083 g cm–3, has been solved by direct methods and refined in the space group C2221 to an R1 index of 1.68% for 7432 observed (|Fo| > 4σ|F|) reflections. Electron-microprobe analysis gave the following chemical composition: As2O510.86, As2O36.18, SiO213.39, Al2O30.25, Fe2O32.06, MnO 51.14, ZnO 7.39, MgO 2.13, CaO 0.05, H2Ocalc = 4.50, sum 97.95 wt.%; and empirical formula: Zn2.91(Mn23.07Mg1.69Ca0.03)Σ=24.79(Fe0.833+Al0.16)Σ=0.99(As3+O3)2[(Si0.71As0.305+)O4]10(OH)16 calculated on the basis of 62 anions with (OH) = 16 and As3+/(As3+ + As5+) taken from the refined crystal structure. The general formula, [4]Zn3(Mn,Mg)25(Fe3+,Al)(As3+O3)2[(Si,As5+)O4]10(OH)16, differs from those given previously.There is one As3+ site with a <As–O> distance of 1.780 Å and a stereochemistry typical of a stereoactive lone-pair of electrons. There are five tetrahedrally coordinated T sites with <T–O> distances from 1.635 to 1.692 Å; the T(1) site is fully occupied by As5+, and the T(2)–T(5) sites are occupied by both Si and As5+. There are two tetrahedrally coordinated Zn sites with <T–O> distances of ∼1.996 Å, both of which are occupied by dominant Zn and minor Mn2+. There are thirteen octahedrally coordinated M sites, twelve of which are occupied by dominant Mn2+ with lesser Mg and minor Zn; <M–O> distances are in the range 2.197–2.284 Å. The <M(13)–O> distance is 2.083 Å and its lower site scattering indicates occupancy by Fe3+, Mn2+, Mg and Al. The structure consists of five crystallographically distinct layers of polyhedra, labelled m = 0 – 4. Layer m = 0 consists of corner-sharing Zn and (Si, As5+) tetrahedra, and layers m = 1–4 each consist of trimers of Mn2+ octahedra linked by (Si, As5+) tetrahedra and intrasheet hydrogen bonds (m = 1, 3) or (Si, As5+) tetrahedra and (Fe3+,Al) octahedra (m = 2) or (As5+) tetrahedra and (As3+O3) triangular pyramids and intrasheet hydrogen bonds (m = 4). The layers stack along [001] with reversals of the sequence m = 1, 2, 3, 4 at z = 0, ¼, ½ and ¾. Kraisslite is a member of the mcgovernite family.
A note on the Analogue of Lebesgue-Radon-Nikodym theorem with respect to weighted p-adic q-measure on "Equation missing"
Authors: Pak Hong Kyung , Rim Seog Hoon , Jeong Joohee 
Published: January 2013

Abstract
We give the analogue of the Lebesgue-Radon-Nikodym theorem with respect to a weighted p-adic q-measure on

Z
p

. In a special case, when the weight

q
x

is 1, we can derive the same result as Kim et al. (Abstr. Appl. Anal. 2011:637634, 2011). And if

q
=
1

, we have the same result as Kim (Russ. J. Math. Phys. 19:193-196, 2012).

MSC:11B68, 11S80.
Differential proteomics and physiology of Pseudomonas putida KT2440 under filament-inducing conditions
Authors: Crabbé Aurélie , Leroy Baptiste , Wattiez Ruddy , Aertsen Abram , Leys Natalie , Cornelis Pierre , Van Houdt Rob 
Published: January 2013

AbstractBackgroundPseudomonas putidaexerts a filamentous phenotype in response to environmental stress conditions that are encountered during its natural life cycle. This study assessed whetherP. putidafilamentation could confer survival advantages. Filamentation ofP. putidawas induced through culturing at low shaking speed and was compared to culturing in high shaking speed conditions, after which whole proteomic analysis and stress exposure assays were performed.ResultsP. putidagrown in filament-inducing conditions showed increased resistance to heat and saline stressors compared to non-filamented cultures. Proteomic analysis showed a significant metabolic change and a pronounced induction of the heat shock protein IbpA and recombinase RecA in filament-inducing conditions. Our data further indicated that the associated heat shock resistance, but not filamentation, was dependent of RecA.ConclusionsThis study provides insights into the altered metabolism ofP. putidain filament-inducing conditions, and indicates that the formation of filaments could potentially be utilized byP. putidaas a survival strategy in its hostile, recurrently changing habitat.
Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients
Authors: Ansemant Thiphaine , Mahy Sophie , Piroth Christine , Ornetti Paul , Ewing Stephanie , Guilland Jean-Claude , Croisier Delphine , Duvillard Laurence , Chavanet Pascal , Maillefert Jean-Francis , Piroth Lionel 
Published: January 2013

Abstract

Background
Even though it has been suggested that antiretroviral therapy has an impact on severe hypovitaminosis D (SHD) in HIV infected patients, it could be speculated that the different levels of residual inflammation on HAART (Highly Active Anti Retroviral Therapy) could contribute to SHD and aggravate bone catabolism in these patients.

Methods
A cross-sectional study was carried out in an unselected cohort of 263 HIV infected outpatients consulting during Spring 2010. Clinical examinations were performed and medical history, food habits, sun exposure and addictions were collected. Fasting blood samples were taken for immunological, virological, inflammation, endocrine and bone markers evaluations.

Results
Ninety-five (36%) patients had SHD. In univariate analysis, a significant and positive association was found between SHD and IL6 (p = 0.001), hsCRP (p = 0.04), increased serum C-Telopeptides X (CTX) (p = 0.005) and Parathyroid Hormon (PTH) (p < 0.0001) levels. In multivariate analysis, SHD deficiency correlated significantly with increased IL-6, high serum CTX levels, lower mean daily exposure to the sun, current or past smoking, hepatitis C, and functional status (falls), but not with the time spent on the current HAART (by specific drug or overall).

Conclusions
SHD is frequent and correlates with inflammation in HIV infected patients. Since SHD is also associated with falls and increased bone catabolism, it may be of interest to take into account not only the type of antiretroviral therapy but also the residual inflammation on HAART in order to assess functional and bone risks. This finding also suggests that vitamin D supplementation may be beneficial in these HIV-infected patients.
Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon
Authors: Senedese Juliana Marques , Alves Jacqueline Morais , Lima Ildercílio Mota de Souza , de Andrade Erick Augusto Pedroso , Furtado Ricardo Andrade , Bastos Jairo Kenupp , Tavares Denise Crispim 
Published: January 2013

Abstract

Background
Natural antioxidants present in common foods and beverages have drawn great attention to cancer prevention due to its health benefits, remarkable lack of toxicity and side effects. Copaifera langsdorffii, known as “copaiba”, “capaiva”, or “pau-de-óleo“, belongs to the Leguminosae family and occurs in fields and grasslands in the northern and northeastern parts of Brazil. Biological studies of Copaifera corroborate its widespread use by the population. This paper describes the effects of C. langsdorffii leaves hydroalcoholic extract on the 1,2-dimethylhydrazine (DMH)-induced DNA damage and aberrant crypt foci (ACF) in the colon of male Wistar rats.

Methods
The hydroalcoholic extract of C. langsdorffii was administered to rats by gavage at daily doses of 20, 40 and 80 mg/kg body weight. To evaluate DNA damage by the comet assay, animals received the C. langsdorffii extract for seven days and a single subcutaneous injection (sc) of 1,2-dimethylhydrazine (DMH) at a dose of 40 mg/kg on day 7. Animals were sacrificed 4 h after injection of DMH, to assess DNA damage. For the ACF assay, animals were acclimatized for one week (week 1) and then treated with the C. langsdorffii extract five times a week for four weeks (weeks 2 to 5). The rats received sc injections of DMH (40 mg/kg) on days 2 and 5 of weeks 2 and 3, to induce ACF. Animals were euthanized at week 5; i.e., four weeks after the first DMH treatment.

Results
Animals treated with different doses of the C. langsdorffii extract combined with DMH had significantly lower frequency of DNA damage as compared with the positive control (animals treated with DMH only). The percentage of reduction in the frequency of DNA damage ranged from 14.30% to 38.8%. The groups treated with 40 and 80 mg/kg C. langsdorffii extract during and after DMH treatment presented significantly lower numbers of ACF and aberrant crypts compared with the control.

Conclusion
The C. langsdorffii extract significantly reduced the extent of DNA damage and ACF induced by DMH, suggesting that the extract has a protective effect against colon carcinogenesis.
Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice
Authors: Castillo-Pichardo Linette , Cubano Luis A , Dharmawardhane Suranganie 
Published: January 2013

Abstract

Background
Resveratrol, a polyphenol from grapes and red wine has many health beneficial effects, including protection against cardiovascular and neurodegenerative diseases and cancer. However, our group and others have provided evidence for a dual cancer promoting or inhibitory role for resveratrol in breast cancer, dependent on estrogenic or antiestrogenic activities. Moreover, much of the inhibitory effects of resveratrol have been reported from studies with high non-physiological concentrations.

Methods
We investigated the effects of a range of concentrations (0.5, 5, 50 mg/kg body weight) of resveratrol on mammary tumor development post-initiation, using immunocompromised mice.

Results
Our findings suggest promotion of mammary tumor growth and metastasis by resveratrol at all concentrations tested in tumors derived from the low metastatic estrogen receptor (ER)α(-), ERβ(+) MDA-MB-231 and the highly metastatic ER(-) MDA-MB-435 cancer cell lines. Additionally, the activity of the migration/invasion regulator Rac, which we have previously shown to be regulated by resveratrol in vitro, was measured in tumors from resveratrol treated mice. Our results show a significant induction of tumoral Rac activity and a trend in increased expression of the Rac downstream effector PAK1 and other tumor promoting molecules following resveratrol treatment.

Conclusion
Taken together, our findings implicate low concentrations of resveratrol in potential promotion of breast cancer. Therefore, this study illuminates the importance of further delineating resveratrol’s concentration dependent effects, particularly in breast cancer, before it can be tested in the clinic or used as a dietary supplement for breast cancer patients.
Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum
Authors: Noone Cariosa , Parkinson Michael , Dowling David J , Aldridge Allison , Kirwan Patrick , Molloy Síle F , Asaolu Samuel O , Holland Celia , O’Neill Sandra M 
Published: January 2013

AbstractBackgroundMalaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected withPlasmodium falciparumfrom four semi-urban villages near Ile-Ife, Osun State, Nigeria.MethodsBlood was obtained from 231 children (aged 39–73 months) who were classified according to meanP. falciparumdensity per μl of blood (uninfected (n = 89), low density (<1,000, n = 51), medium density (1,000-10,000, n = 65) and high density (>10,000, n = 22)). IL-12p70, IL-10, Nitric oxide, IFN-γ, TNF, IL-17, IL-4 and TGF-β, C-C chemokine RANTES, MMP-8 and TIMP-1 were measured in plasma. Peripheral blood mononuclear cells were obtained and examined markers of innate immune cells (CD14, CD36, CD56, CD54, CD11c AND HLA-DR). T-cell sub-populations (CD4, CD3 and γδTCR) were intracellularly stained for IL-10, IFN-γ and TNF following polyclonal stimulation or stimulated with malaria parasites.Ascaris lumbricoideswas endemic in these villages and all data were analysed taking into account the potential impact of bystander helminth infection. All data were analysed using SPSS 15 for windows and in all tests,p<0.05 was deemed significant.ResultsThe level ofP. falciparumparasitaemia was positively associated with plasma IL-10 and negatively associated with IL-12p70. The percentage of monocytes was significantly decreased in malaria-infected individuals while malaria parasitaemia was positively associated with increasing percentages of CD54+, CD11c+and CD56+cell populations. No association was observed in cytokine expression in mitogen-activated T-cell populations between groups and no malaria specific immune responses were detected. AlthoughA. lumbricoidesis endemic in these villages, an analysis of the data showed no impact of this helminth infection onP. falciparumparasitaemia or on immune responses associated withP. falciparuminfection.ConclusionsThese findings indicate that Nigerian children infected withP. falciparumexhibit immune responses associated with active malaria infection and these responses were positively associated with increasedP. falciparumparasitaemia.
Calcium plus vitamin D3 supplementation facilitated Fat loss in overweight and obese college students with very-low calcium consumption: a randomized controlled trial
Authors: Zhu Wei , Cai Donglian , Wang Ying , Lin Ning , Hu Qingqing , Qi Yang , Ma Shuangshuang , Amarasekara Sidath 
Published: January 2013

Abstract

Background
Recent evidence suggests that higher calcium and/or vitamin D intake may be associated with lower body weight and better metabolic health. Due to contradictory findings from intervention trials, we investigated the effect of calcium plus vitamin D3 (calcium+D) supplementation on anthropometric and metabolic profiles during energy restriction in healthy, overweight and obese adults with very-low calcium consumption.

Methods
Fifty-three subjects were randomly assigned in an open-label, randomized controlled trial to receive either an energy-restricted diet (−500 kcal/d) supplemented with 600 mg elemental calcium and 125 IU vitamin D3 or energy restriction alone for 12 weeks. Repeated measurements of variance were performed to evaluate the differences between groups for changes in body weight, BMI, body composition, waist circumference, and blood pressures, as well as in plasma TG, TC, HDL, LDL, glucose and insulin concentrations.

Results
Eighty-one percent of participants completed the trial (85% from the calcium + D group; 78% from the control group). A significantly greater decrease in fat mass loss was observed in the calcium + D group (−2.8±1.3 vs.-1.8±1.3 kg; P=0.02) than in the control group, although there was no significant difference in body weight change (P>0.05) between groups. The calcium + D group also exhibited greater decrease in visceral fat mass and visceral fat area (P<0.05 for both). No significant difference was detected for changes in metabolic variables (P>0.05).

Conclusion
Calcium plus vitamin D3 supplementation for 12 weeks augmented body fat and visceral fat loss in very-low calcium consumers during energy restriction.

Trial registration
ClinicalTrials.gov (NCT01447433, http://clinicaltrials.gov/).
Resection of an intra-operative ruptured hepatocellular carcinoma with continuous pringle maneuver and in situ hypothermic perfusion through the inferior mesenteric vein - a case report
Authors: Lin Yueh-Ming , Chiang Li-Wei , Wang Shih-Ho , Lin Chih-Che , Chen Chao-Long , Millan Carlos A , Wang Chih-Chi 
Published: January 2013

Abstract
Intra-operative tumor rupture is a serious complication during resection of large hepatocellular carcinoma (HCC) leading to more blood loss. We report our experience in applying continuous Pringle maneuver with in situ hypothermic perfusion via inferior mesenteric vein catheterization to the portal vein of the remnant liver for resection during an extended left lobectomy of a large HCC which ruptured intraoperatively. Using this method, we successfully managed the patient without any further morbidity. This technique provides easier accessibility of in situ perfusion, decreases operative blood loss and prevents warm ischemic injury to the remnant liver during parenchymal transection. This method could be effective for the resection of large ruptured HCC.
Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection
Authors: Zeng Jun , Yang Xudan , Cheng Lin , Liu Rui , Lei Yunlong , Dong Dandan , Li Fanghua , Lau Quek Choon , Deng Longfei , Nice Edouard C , Xie Ke , Huang Canhua 
Published: January 2013

AbstractBackgroundThe chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern and significance of CXCL14 in CRC progression.Method265 colorectal carcinoma specimens and 129 matched adjacent normal colorectal mucosa specimens were collected. Expression of CXCL14 in clinical samples was examined by immunostaining. The effect of CXCL14 on colorectal carcinoma cell proliferation was measured by MTT assay, BrdU incorporation assay and colony formation assay. The impact of CXCL14 on migration and invasion of colorectal carcinoma cells was determined by transwell assay and Matrigel invasion assay, respectively.ResultsCXCL14 expression was significantly up-regulated in tumor tissues compared with adjacent nontumorous mucosa tissues (P < 0.001). Tumoral CXCL14 expression levels were significantly correlated with TNM (Tumor-node-metastasis) stage, histodifferentiation, and tumor size. In multivariate Cox regression analysis, high CXCL14 expression in tumor specimens (n = 91) from stage I/II patients was associated with increased risk for disease recurrence (risk ratio, 2.92; 95% CI, 1.15-7.40;P = 0.024). Elevated CXCL14 expression in tumor specimens (n = 135) from stage III/IV patients correlated with worse overall survival (risk ratio, 3.087; 95% CI, 1.866-5.107;P < 0.001). Functional studies demonstrated that enforced expression of CXCL14 in SW620 colorectal carcinoma cells resulted in more aggressive phenotypes. In contrast, knockdown of CXCL14 expression could mitigate the proliferative, migratory and invasive potential of HCT116 colorectal carcinoma cells.ConclusionTaken together, CXCL14 might be a potential novel prognostic factor to predict the disease recurrence and overall survival and could be a potential target of postoperative adjuvant therapy in CRC patients.
Multi-scale numerical simulations of thermal expansion properties of CNT-reinforced nanocomposites
Authors: Alamusi  , Hu Ning , Qiu Jianhui , Li Yuan , Chang Christiana , Atobe Satoshi , Fukunaga Hisao , Liu Yaolu , Ning Huiming , Wu Liangke , Li Jinhua , Yuan Weifeng , Watanabe Tomonori , Yan Cheng , Zhang Yajun 
Published: January 2013

Abstract
In this work, the thermal expansion properties of carbon nanotube (CNT)-reinforced nanocomposites with CNT content ranging from 1 to 15 wt% were evaluated using a multi-scale numerical approach, in which the effects of two parameters, i.e., temperature and CNT content, were investigated extensively. For all CNT contents, the obtained results clearly revealed that within a wide low-temperature range (30°C ~ 62°C), thermal contraction is observed, while thermal expansion occurs in a high-temperature range (62°C ~ 120°C). It was found that at any specified CNT content, the thermal expansion properties vary with temperature - as temperature increases, the thermal expansion rate increases linearly. However, at a specified temperature, the absolute value of the thermal expansion rate decreases nonlinearly as the CNT content increases. Moreover, the results provided by the present multi-scale numerical model were in good agreement with those obtained from the corresponding theoretical analyses and experimental measurements in this work, which indicates that this multi-scale numerical approach provides a powerful tool to evaluate the thermal expansion properties of any type of CNT/polymer nanocomposites and therefore promotes the understanding on the thermal behaviors of CNT/polymer nanocomposites for their applications in temperature sensors, nanoelectronics devices, etc.