bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal fraction in maternal plasma cell‐free DNA at 11–13 weeks' gestation: relation to maternal and fetal characteristics
Authors: Ashoor G. , Syngelaki A. , Poon L. C. Y. , Rezende J. C. , Nicolaides K. H. 
Published: October 2012

AbstractObjectiveTo examine the possible effects of maternal and fetal characteristics on the fetal fraction in maternal plasma cell‐free (cf) DNA at 11–13 weeks' gestation and estimate the proportion of pregnancies at high risk of non‐invasive prenatal testing (NIPT) failure because the fetal fraction is less than 4%.MethodsIn 1949 singleton pregnancies at 11–13 weeks' gestation cf‐DNA was extracted from maternal plasma. Chromosome‐selective sequencing of non‐polymorphic and polymorphic loci, where fetal alleles differ from maternal alleles, was used to determine the proportion of cf‐DNA that was of fetal origin. Multivariable regression analysis was used to determine significant predictors of the fetal fraction among maternal and fetal characteristics.ResultsThe fetal fraction decreased with increased maternal weight, it was lower in women of Afro‐Caribbean origin than in Caucasians and increased with fetal crown–rump length, serum pregnancy‐associated plasma protein‐A, serum free β‐human chorionic gonadotropin, smoking and trisomy 21 karyotype. The median fetal fraction was 10.0% (interquartile range, 7.8–13.0%) and this decreased with maternal weight from 11.7% at 60 kg to 3.9% at 160 kg. The estimated proportion with fetal fraction below 4% increased with maternal weight from 0.7% at 60 kg to 7.1% at 100 kg and 51.1% at 160 kg.ConclusionsFetal fraction in maternal plasma cf‐DNA is affected by maternal and fetal characteristics.Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Plastie pénoscrotale pour volumineux éléphantiasis des organes génitaux externes : à propos d’un cas à la clinique universitaire d’urologie-andrologie de Cotonou
Authors: Gandaho I. , Avakoudjo J. , Hounnasso P. -P. , Hodonou F. , Akpo C. 
Published: October 2012

Résumé
Bien qu’ayant été par le passé une zone d’endémie filarienne, les séquelles de la filariose lymphatique deviennent de plus en plus rares au Bénin. Nous rapportons un cas de volumineux éléphantiasis pénoscrotal pris en charge à la clinique universitaire d’urologie-andrologie de Cotonou. Il a été réalisé une plastie pénoscrotale par réduction volumétrique et reconstitution scrotale par deux lambeaux latéraux. Les résultats après un recul de six mois sont satisfaisants.
Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer
Authors: Wei Siwei , Liu Lingyan , Zhang Jian , Bowers Jeremiah , Gowda G.A. Nagana , Seeger Harald , Fehm Tanja , Neubauer Hans J. , Vogel Ulrich , Clare Susan E. , Raftery Daniel 
Published: October 2012

Breast cancer is a clinically heterogeneous disease, which necessitates a variety of treatments and leads to different outcomes. As an example, only some women will benefit from chemotherapy. Identifying patients who will respond to chemotherapy and thereby improve their long‐term survival has important implications to treatment protocols and outcomes, while identifying non responders may enable these patients to avail themselves of other investigational approaches or other potentially effective treatments. In this study, serum metabolite profiling was performed to identify potential biomarker candidates that can predict response to neoadjuvant chemotherapy for breast cancer. Metabolic profiles of serum from patients with complete (n = 8), partial (n = 14) and no response (n = 6) to chemotherapy were studied using a combination of nuclear magnetic resonance (NMR) spectroscopy, liquid chromatography–mass spectrometry (LC–MS) and statistical analysis methods. The concentrations of four metabolites, three (threonine, isoleucine, glutamine) from NMR and one (linolenic acid) from LC–MS were significantly different when comparing response to chemotherapy. A prediction model developed by combining NMR and MS derived metabolites correctly identified 80% of the patients whose tumors did not show complete response to chemotherapy. These results show promise for larger studies that could result in more personalized treatment protocols for breast cancer patients.
TYPES OF MARRIAGES, POPULATION STRUCTURE AND GENETIC DISEASE
Authors: MACHADO T. M. B. , BOMFIM T. F. , SOUZA L. V. , SOARES N. , SANTOS F. L. , ACOSTA A. X. , ABE-SANDES K. 
Published: October 2012

SummaryA high occurrence rate of consanguineous marriages may favour the onset and increased frequency of autosomal recessive diseases in a population. The population of Monte Santo, Bahia, Brazil, has a high frequency of rare genetic diseases such as mucopolysaccharidosis type VI, whose observed frequency in this population is 1:5000, while the incidence of this disease recorded in other regions of the world varies from 1:43,261 in Turkey to 1:1,505,160 in Switzerland. To verify the influence of consanguineous marriage on the increased frequency of observed genetic diseases in this population, the population structure and frequency of different types of marriage during different time periods were evaluated. A total of 9765 marriages were found in an analysis of parish marriage records from the city. Over three periods, 1860–1895, 1950–1961 and 1975–2010, the inbreeding rates were 37.1%, 13.2% and 4.2% respectively. Although there was a high rate of inbreeding, endogamic marriages were the dominant marriage type in all three periods. In the most recent period, there was an increase in the number of exogamous marriages and those among immigrants, but most of these occurred among individuals from cities that neighbour Monte Santo. The low rate of migration and high frequency of endogamic and consanguineous marriages show that growth of this population is predominantly internal and could explain the occurrence, and increase in frequency, of recessive genetic diseases in the city.
Neurocognitive Late Effects of Pediatric Brain Tumors of the Posterior Fossa: A Quantitative Review
Authors: Robinson Kristen E. , Fraley Claire E. , Pearson Matthew M. , Kuttesch John F. , Compas Bruce E. 
Published: October 2012

AbstractDeficits in neurocognitive functioning are an important area of late effects in survivors of pediatric brain tumors; however, a quantitative analysis of the magnitude of these deficits in survivors of brain tumors of the posterior fossa has not been conducted. Despite tumor locations in the posterior regions of the brain, individual studies have documented deficits in a variety of domains, reflective of impairment in other brain regions. The current study provides a comprehensive meta-analysis of literature on neurocognitive late effects found in survivors of posterior fossa tumors. Results indicated significant deficits in both specific and broad indices of neurocognitive functioning, and the overall magnitude of effects across domains ranged from medium to large (g= −0.62 to −1.69) with a large mean overall effect size (g= −1.03). Moderator analyses indicated significantly greater effects for survivors diagnosed at a younger age and those who received radiation therapy. These findings underscore the importance of monitoring neurocognitive late effects in survivors of pediatric brain tumors of the posterior fossa, as well as the need for more consistent consideration of demographic, diagnostic, and treatment-related variables to allow for examination of factors that moderate these deficits. (JINS, 2012,19, 1–10)
Prospective Memory and Antiretroviral Medication Non-Adherence in HIV: An Analysis of Ongoing Task Delay Length Using the Memory for Intentions Screening Test
Authors: Poquette Amelia J. , Moore David J. , Gouaux Ben , Morgan Erin E. , Grant Igor , Woods Steven Paul ,   The HNRP Group
Published: October 2012

AbstractUsing multi-process framework by McDaniel and Einstein (2000), the current study examined whether the length of prospective memory (PM) delay intervals as measured by the 2- and 15-min subscales of the Memory for Intentions Screening Test (MIST) have differential predictive value for antiretroviral (ARV) adherence. Participants included 74 HIV-infected individuals whose ARV adherence was tracked with an electronic monitoring system. Participants were classified as “adherent” (n = 49) or “non-adherent” (n = 25) based on recorded pill bottle openings of ≥90% of prescribed doses over 30 days. An adherence group by MIST delay interval interaction was observed, such that non-adherent participants had worse performance on the 15-min, but not 2-min delay PM MIST subscales. The observed MIST 15-min delay effects were significantly more pronounced on time- versus event-cued PM trials. Long-delay time-based PM was predictive of non-adherence independent of demographics, mood state, self-reported adherence, and general cognitive functioning. Findings from this clinical study indicate that ARV non-adherence may be particularly associated with deficits in strategic cue monitoring over longer PM delays, which may inform interventions to improve adherence among persons living with HIV infection. (JINS, 2012, 18, 1–7)
Microscopy and Microanalysis of Hematological Parameters in Common Carp, Cyprinus carpio, Inhabiting a Polluted Lake in North East India
Authors: Massar Bashida , Dey Sudip , Barua R. , Dutta K. 
Published: October 2012

AbstractOptical and scanning electron microscopy (SEM) of red blood cells (RBCs) of common carp, Cyprinus carpio, inhabiting a polluted lake in Northeast India revealed a number of abnormalities. About 7% of the RBC showed the presence of a micronucleus, besides the presence of some bi-nucleated and abnormally shaped nuclei. RBCs, white blood cells, and hemoglobin content were found to be reduced significantly as compared to the control. SEM showed the presence of spherocytes, early stages of echinocytes, cytoplasmic blebbing, erythrocytes with contraction from one side, abnormal shape of erythrocytes (hexagonal/pentagonal/tetragonal), development of lobopodial projections, cell rupture, membrane internalization, and formation of ring-shaped RBC. Energy dispersive X-ray spectroscopy (EDS) showed the presence of a considerable percentage of silicon and lead in erythrocytes of the fish collected from the polluted lake, in contrast to a negligible concentration of the two elements in control fish. Significance of the study in relation to fish health in a polluted body of water and the importance of SEM, EDS, and light microscopy in utilizing hematological parameters as pollution indicators are discussed.
Structure of the subduction system in southern Peru from seismic array data
Authors: Phillips Kristin , Clayton Robert W. , Davis Paul , Tavera Hernando , Guy Richard , Skinner Steven , Stubailo Igor , Audin Laurence , Aguilar Victor 
Published: October 2012

The subduction zone in southern Peru is imaged using converted phases from teleseismic P, PP, and PKP waves and Pwave tomography using local and teleseismic events with a linear array of 50 broadband seismic stations spanning 300 km from the coast to near Lake Titicaca. The slab dips at 30° and can be observed to a depth of over 200 km. The Moho is seen as a continuous interface along the profile, and the crustal thickness in the back‐arc region (the Altiplano) is 75 km thick, which is sufficient to isostatically support the Andes, as evidenced by the gravity. The shallow crust has zones of negative impedance at a depth of 20 km, which is likely the result of volcanism. At the midcrustal level of 40 km, there is a continuous structure with a positive impedance contrast, which we interpret as the western extent of the Brazilian Craton as it underthrusts to the west.Vp/Vs ratios estimated from receiver function stacks show average values for this region with a few areas of elevated Vp/Vs near the volcanic arc and at a few points in the Altiplano. The results support a model of crustal thickening in which the margin crust is underthrust by the Brazilian Shield.
Variability of the Denmark Strait overflow: Moored time series from 1996–2011
Authors: Jochumsen Kerstin , Quadfasel Detlef , Valdimarsson Heðinn , Jónsson Steingrímur 
Published: October 2012

The Denmark Strait overflow provides about half of the total dense water overflow from the Nordic Seas into the North Atlantic Ocean. The velocity of the overflow has been monitored in the Strait with two moored Acoustic Doppler Current Profilers since 1996 with several interruptions due to mooring losses or instrument failure. So far, overflow transports were only calculated when data from both moorings were available. In this work, we introduce a linear model to fill gaps in the time series when data from only one instrument is available. The mean overflow transport is 3.4 Sv and exhibits a variance of 2.0 Sv2. No significant trend was detected in the time series. The highest variability in the transport is associated with the passage of mesoscale eddies with time scales of 2–10 days (associated with a variance of 1.5 Sv2). Seasonal variability is weak and explains less than 5% of the variance in all time series, which is in contrast to the strong seasonal cycle found in high resolution model simulations. Interannual variability is on the order of 10% of the mean. A relation to atmospheric forcing such as the local wind stress curl, as well as to larger scale phenomena, e.g. the North Atlantic Oscillation, is not detected. Since 2005 data from moored temperature, conductivity and pressure recorders have been available as well, monitoring the hydrographic variability at the bottom of Denmark Strait. In recent years the temperature time series of the Denmark Strait overflow revealed a cooling, while the salinity stayed nearly constant.
Evidence of Eu2+ 4f electrons in the valence band spectra of EuTiO3 and EuZrO3
Authors: Kolodiazhnyi T. , Valant M. , Williams J. R. , Bugnet M. , Botton G. A. , Ohashi N. , Sakka Y. 
Published: October 2012

We report on optical band gap and valence electronic structure of two Eu2+-based perovskites, EuTiO3 and EuZrO3 as revealed by diffuse optical scattering, electron energy loss spectroscopy, and valence-band x-ray photoelectron spectroscopy. The data show good agreement with the first-principles studies in which the top of the valence band structure is formed by the narrow Eu 4f7 electron band. The O 2p band shows the features similar to those of the Ba(Sr)TiO3 perovskites except that it is shifted to higher binding energies. Appearance of the Eu2+ 4f7 band is a reason for narrowing of the optical band gap in the title compounds as compared to their Sr-based analogues.
Dissociative versus Associative Responses to Social Identity Threat: The Role of Consumer Self-Construal
Authors: White Katherine , Argo Jennifer J. , Sengupta Jaideep 
Published: October 2012

Abstract
The current research examines the conditions under which consumers demonstrate associative versus dissociative responses to identity-linked products as a consequence of a social identity threat. Across four studies, the authors test the notion that reactions to social identity threat may be moderated by self-construal by examining subcultural differences in ethnic background, priming self-construal, and investigating cross-national differences in cultural background. Those with more independent self-construals tend to avoid identity-linked products when that identity is threatened versus not threatened. Those with more interdependent self-construals, in contrast, demonstrate more positive preferences for identity-linked products when that aspect of social identity is threatened. These effects arise because, while independents are motivated to restore positive self-worth when a social identity is threatened, interdependents access a repertoire of social identities to fulfill belongingness needs when threatened.
The Exception Is the Rule: Underestimating and Overspending on Exceptional Expenses
Authors: Sussman Abigail B. , Alter Adam L. 
Published: October 2012

Abstract
Purchases fall along a continuum from ordinary (common or frequent) to exceptional (unusual or infrequent), with many of the largest expenses (e.g., electronics, celebrations) being the most exceptional. Across seven studies, we show that, while people are fairly adept at budgeting and predicting how much they will spend on ordinary items, they both underestimate their spending on exceptional purchases overall and overspend on each individual purchase. Based on the principles of mental accounting and choice bracketing, we show that this discrepancy arises in part because consumers categorize exceptional expenses too narrowly, construing each as a unique occurrence and consequently overspending across a series of discretely exceptional expenses. We conclude by proposing an intervention that diminishes this tendency by helping consumers consider their spending on exceptional items as part of a larger set of purchases.
Frustrated Fatshionistas: An Institutional Theory Perspective on Consumer Quests for Greater Choice in Mainstream Markets
Authors: Scaraboto Daiane , Fischer Eileen 
Published: October 2012

Abstract
Why and how do marginalized consumers mobilize to seek greater inclusion in and more choice from mainstream markets? We develop answers to these questions drawing on institutional theory and a qualitative investigation of Fatshionistas, plus-sized consumers who want more options from mainstream fashion marketers. Three triggers for mobilization are posited: development of a collective identity, identification of inspiring institutional entrepreneurs, and access to mobilizing institutional logics from adjacent fields. Several change strategies that reinforce institutional logics while unsettling specific institutionalized practices are identified. Our discussion highlights diverse market change dynamics that are likely when consumers are more versus less legitimate in the eyes of mainstream marketers and in instances where the changes consumers seek are more versus less consistent with prevailing institutions and logics.
Money Isn’t Everything, but It Helps If It Doesn’t Look Used: How the Physical Appearance of Money Influences Spending
Authors: Di Muro Fabrizio , Noseworthy Theodore J. 
Published: October 2012

Abstract
Despite evidence that currency denomination can influence spending, researchers have yet to examine whether the physical appearance of money can do the same. This is important because smaller denomination bills tend to suffer greater wear than larger denomination bills. Using real money in the context of real purchases, this article demonstrates that the physical appearance of money can override the influence of denomination. The reason being, people want to rid themselves of worn bills because they are disgusted by the contamination from others, whereas people put a premium on crisp currency because they take pride in owning bills that can be spent around others. This suggests that the physical appearance of money matters more than traditionally thought, and like most things in life, it too is inextricably linked to the social context. The results suggest that money may be less fungible than people think.
Cost-Effectiveness of Different Screening Strategies (Single or Dual) for the Diagnosis of Tuberculosis Infection in Healthcare Workers
Authors: del Campo M. Teresa , Fouad Hadia , Solís-Bravo M. Marcela , Sánchez-Uriz M. Angeles , Mahíllo-Fernández Ignacio , Esteban Jaime 
Published: October 2012

Objective.To evaluate the cost-effectiveness of a dual strategy of tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT-G) for screening of latent tuberculosis infection (LTBI) in healthcare workers (HCWs) and, as a secondary objective, to study relationships between TST results, QFT-G results, and sociodemographic factors.Design.Cross-sectional prospective study.Setting.University hospital in Madrid.Participants.A total of 103 HCWs.Methods.QFT-G was requested for all positive TST results; QFT-G results were compared with TST results, and their relationships with sociodemographic factors were analyzed. A cost-effectiveness analysis was conducted for the dual strategy (TST/QFT-G) and for TST or QFT alone, taking into account the indication of and compliance with isoniazid, the risk of hepatotoxicity, and postexposure tuberculosis.Results.Of all HCWs studied, 42.3% showed a positive result by QFT-G, and 49.5% had received bacille Calmette-Guérin (BCG) vaccination; no significant association was detected between BCG and QFT-G results. Increased TST was linked to higher positive QFT-G values (TST of 5–9.9 mm, 27.6%; TST of 15 mm or more, 56.5%; P = .03). The probability of positive QFT-G results was 1.04 times higher for each year of age (odds ratio, 1.04 [95% confidence interval, 1.01–1.09]; P = .0257). The incremental cost per active TB case prevented was lower for TST/QFT-G than for the other strategies studied (€14,211 per 1,000 HCWs). The number of people treated for LTBI per case of active TB prevented (number needed to treat) for TST/QFT-G was lower than for TST alone (17.2 vs 95.3 and 88.7 with the 5- and 10-mm cutoff value, respectively) or QFT-G alone (69.6).Conclusions.Dual strategy with TST/QFT-G is more cost-effective than TST or QFT-G alone for the diagnosis of LTBI in HCWs.
Two distinct SSB protein families in nucleo-cytoplasmic large DNA viruses
Authors: Kazlauskas Darius , Venclovas Česlovas 
Published: October 2012

Abstract
Motivation: Eukaryote-infecting nucleo-cytoplasmic large DNA viruses (NCLDVs) feature some of the largest genomes in the viral world. These viruses typically do not strongly depend on the host DNA replication systems. In line with this observation, a number of essential DNA replication proteins, such as DNA polymerases, primases, helicases and ligases, have been identified in the NCLDVs. One other ubiquitous component of DNA replisomes is the single-stranded DNA-binding (SSB) protein. Intriguingly, no NCLDV homologs of canonical OB-fold-containing SSB proteins had previously been detected. Only in poxviruses, one of seven NCLDV families, I3 was identified as the SSB protein. However, whether I3 is related to any known protein structure has not yet been established.
Results: Here, we addressed the case of ‘missing’ canonical SSB proteins in the NCLDVs and also probed evolutionary origins of the I3 family. Using advanced computational methods, in four NCLDV families, we detected homologs of the bacteriophage T7 SSB protein (gp2.5). We found the properties of these homologs to be consistent with the SSB function. Moreover, we implicated specific residues in single-stranded DNA binding. At the same time, we found no evolutionary link between the T7 gp2.5-like NCLDV SSB homologs and the poxviral SSB protein (I3). Instead, we identified a distant relationship between I3 and small protein B (SmpB), a bacterial RNA-binding protein. Thus, apparently, the NCLDVs have the two major distinct sets of SSB proteins having bacteriophage and bacterial origins, respectively.
Contact: venclovas@ibt.lt
Supplementary information: Supplementary data are available at Bioinformatics online.