bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of the spray angle on thermally sprayed heating coatings
Authors: Bobzin K. , Heinemann H. , Erck M. , Schacht A. , Hopmann C. , Fritsche D. , Kahve C. , Vogels C. 
Published: August 2024

AbstractTemperature control of mould surfaces is of high relevance for part quality in moulding processes. Due to highly dynamic heating behaviour, heating elements applied by thermal spraying can be an alternative to existing tempering methods. To ensure the feasibility of these heating coatings on industry‐relevant moulds, the coating system needs to be applied onto more demanding non‐flat geometries. For this purpose, the spray angle of the plasma spraying process is varied during the application of the titanium oxide/chromium oxide heating coating and the insulating aluminium oxide coating. Subsequently, the results are related to application‐oriented cavity shapes. Spray angle deviations from the optimal perpendicular angle are leading to decreasing dielectric strength of the coating system and an increase of the electrical resistivity. Additionally, the application efficiency reduces with the spray angle variation. Knowledge of the spray angle's influence on coating properties can help to coat more demanding shapes, including free formed surfaces or corners.
Exploring Analysis Approaches for Using the Dopamine Transporter Striatal Binding Ratio in Early‐ to Mid‐Stage Parkinson's Disease Modification Trials
Authors: Vijiaratnam Nirosen , Girges Christine , Athauda Dilan , King Alexa , Auld Grace , McComish Rachel , Chowdhury Kashfia , Skene Simon , Maclagan Kate , Chaudhuri Kallol Ray , Libri Vincenzo , Dickson John , Foltynie Thomas 
Published: August 2024

AbstractBackgroundThe dopamine transporter striatal binding ratio (DAT SBR) has been used as an outcome measure in Parkinson's disease (PD) trials of potential disease‐modifying therapies; however, both patient characteristics and analysis approach potentially complicate its interpretation.ObjectiveThe aim was to explore how well DAT SBR reflects PD motor severity across different striatal subregions and the relationship to disease duration, and side of onset.MethodsDAT SBR for the anterior and posterior putamen and caudate in both hemispheres was obtained using validated automated quantitative software on baseline scans of 132 patients recruited for the Exenatide PD2 and PD3 trials. Associations between mean and lateralized SBR subregions (posterior and anterior putamen and caudate) and summed and lateralized motor characteristics were explored using regression analysis. Analyses were repeated considering disease duration and limiting analysis to the less‐affected hemisphere.ResultsLateralized bradykinesia was most consistently associated with the loss of DAT uptake in the contralateral anterior putamen. There was much higher variance in the posterior putamen, and in all regions in those with longer duration disease, although bradykinesia remained robustly associated with anterior putaminal DAT uptake even in longer‐duration patients. Restricting analyses to the less‐affected side did not usefully reduce the variance compared to the overall cohort.ConclusionThese data suggest that DAT SBR could be a useful biomarker in disease‐modifying trials, but a focus on anterior striatal subregions and incorporating disease duration into analyses may improve its utility.
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology
Authors: Zununi Vahed Sepideh , Hosseiniyan Khatibi Seyed Mahdi , Ardalan Mohammadreza 
Published: August 2024

AbstractGlomerulonephritis (GN) is an important cause of renal inflammation resulting from kidney‐targeted adaptive and innate immune responses and consequent glomerular damage. Given the lack of autoantibodies, immune complexes, or the infiltrating immune cells in some forms of GN, for example, focal segmental glomerulosclerosis and minimal change disease, along with paraneoplastic syndrome and a special form of renal involvement in some viral infections, the likeliest causative scenario would be secreted factors, mainly cytokine(s). Since cytokines can modulate the inflammatory mechanisms, severity, and clinical outcomes of GN, it is rational to consider the umbrella term of cytokine GN as a new outlook to reclassify a group of previously known GN. We focus here, particularly, on cytokines that have the central “canonical effect” in the development of GN.
Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future
Authors: Li Junfang , Wang Xiaodong , Zhang Honghua , Hu Xiaoling , Peng Xue , Jiang Weifan , Zhuo Linsheng , Peng Yan , Zeng Guo , Wang Zhen 
Published: August 2024

AbstractFenamates as classical nonsteroidal anti‐inflammatory agents are widely used for relieving pain. Preclinical studies and epidemiological data highlight their chemo‐preventive and chemotherapeutic potential for cancer. However, comprehensive reviews of fenamates in cancer are limited. To accelerate the repurposing of fenamates, this review summarizes the results of fenamates alone or in combination with existing chemotherapeutic agents. This paper also explores targets of fenamates in cancer therapy, including COX, AKR family, AR, gap junction, FTO, TEAD, DHODH, TAS2R14, ion channels, and DNA. Besides, this paper discusses other mechanisms, such as regulating Wnt/β‐catenin, TGF‐β, p38 MAPK, and NF‐κB pathway, and the regulation of the expressions of Sp, EGR‐1, NAG‐1, ATF‐3, ErbB2, AR, as well as the modulation of the tumor immune microenvironment. Furthermore, this paper outlined the structural modifications of fenamates, highlighting their potential as promising leads for anticancer drugs.
A GCPW slow‐wave transmission line with improved wavelength reduction technique by adopting capacitor array
Authors: Chang Ngu Quyen , Yun Byeonghun , Park Dae‐Woong , Lee Sang‐Gug 
Published: August 2024

AbstractThis letter presents a grounded coplanar waveguide (GCPW) slow‐wave transmission line (SWTL) with an improved wavelength reduction technique by adopting capacitor array. By cross‐interleaving additional capacitors between a signal line and side ground planes, the total capacitance in the capacitor array increases approximately two times compared to the conventional structure, allowing designers to choose a smaller signal conductor's width for higher inductance, thus, improving wavelength reduction performance while preserving the same characteristic impedance. At the 150 GHz frequency of interest, the proposed GCPW SWTL shows approximately 20% and 62.16% reduction in wavelength compared to the reported GCPW SWTL and regular CPW, respectively, with the same characteristic impedance. To prove the effectiveness of the proposed SWTL concept, the proposed GCPW SWTL test patterns are fabricated in a 65 nm CMOS process.
HerbMet: Enhancing metabolomics data analysis for accurate identification of Chinese herbal medicines using deep learning
Authors: Sha Yuyang , Jiang Meiting , Luo Gang , Meng Weiyu , Zhai Xiaobing , Pan Hongxin , Li Junrong , Yan Yan , Qiao Yongkang , Yang Wenzhi , Li Kefeng 
Published: August 2024

AbstractIntroductionChinese herbal medicines have been utilized for thousands of years to prevent and treat diseases. Accurate identification is crucial since their medicinal effects vary between species and varieties. Metabolomics is a promising approach to distinguish herbs. However, current metabolomics data analysis and modeling in Chinese herbal medicines are limited by small sample sizes, high dimensionality, and overfitting.ObjectivesThis study aims to use metabolomics data to develop HerbMet, a high‐performance artificial intelligence system for accurately identifying Chinese herbal medicines, particularly those from different species of the same genus.MethodsWe propose HerbMet, an AI‐based system for accurately identifying Chinese herbal medicines. HerbMet employs a 1D‐ResNet architecture to extract discriminative features from input samples and uses a multilayer perceptron for classification. Additionally, we design the double dropout regularization module to alleviate overfitting and improve model's performance.ResultsCompared to 10 commonly used machine learning and deep learning methods, HerbMet achieves superior accuracy and robustness, with an accuracy of 0.9571 and an F1‐score of 0.9542 for distinguishing seven similar Panax ginseng species. After feature selection by 25 different feature ranking techniques in combination with prior knowledge, we obtained 100% accuracy and an F1‐score for discriminating P. ginseng species. Furthermore, HerbMet exhibits acceptable inference speed and computational costs compared to existing approaches on both CPU and GPU.ConclusionsHerbMet surpasses existing solutions for identifying Chinese herbal medicines species. It is simple to use in real‐world scenarios, eliminating the need for feature ranking and selection in classical machine learning‐based methods.
Enhanced sustainable packaging solutions through corn stover‐reinforced polypropylene biomass composites: Characterization, performance, and potential applications
Authors: Du Jian‐Hua , Yao Wei‐Hua , Tsou Chih‐Yuan , Wu Chin‐San , Meng Lei , Hu Xue‐Fei , Tsou Chi‐Hui 
Published: August 2024

AbstractThis research systematically explores the use of corn stover (CS) with polypropylene (PP) and modified polypropylene (MPP) for sustainable food packaging. MPP is produced via melt mixing with dicumyl peroxide followed by maleic anhydride. The study aims to assess the potential of these biomass composites in eco‐friendly packaging applications. Our comprehensive evaluations include crystalline behavior, water absorption rate, contact angle, water vapor permeation coefficients, and oxygen transmission rates. Notably, at 20% CS content, the tensile strength of the MPP/CS composite material is about 120% higher than PP/CS composites. We also observed that CS significantly alters key properties of PP and MPP. The weight loss analysis of vegetables and water vapor transmission rate tests indicate that the MPP/CS composite film with 20% CS has the best effect on water vapor barrier and preservation of vegetables. Additionally, microbial growth analysis reveals that Escherichia coli and Staphylococcus aureus grow less abundantly on composites with lower CS contents, and MPP/CS composites show reduced microbial growth compared to PP/CS. This integrated study demonstrates the optimization of composite material performance through CS variables, revealing innovative potential for CS in enhancing PP and guiding the design of future sustainable packaging materials.Highlights
20% CS in MPP/CS boosts tensile strength by 120% versus PP/CS composites.
20% CS in MPP/CS gives optimal water vapor barrier and veggie preservation.
MPP/CS reduces E. coli and S. aureus growth better than PP/CS, especially at low CS.
MPP's functional group enhances CS compatibility, dispersion, structure, and crystallinity.
Corn stover‐reinforced PP composites offer a sustainable, eco‐friendly packaging option.
If They'd Said You Should Only Drink Five Units I'd Have Listened: A Mixed Methods Study of Alcohol Consumption Following a Diagnosis of Breast Cancer
Authors: Davies Emma L. , McGeagh Lucy , Matheson Lauren , Bennett Julie , Matthews Sara , Brett Jo , Watson Eila 
Published: August 2024

ABSTRACTObjectivesAs part of a wider study describing the impact of a breast cancer diagnosis on lifestyle behaviours, this paper describes the impact of a breast cancer diagnosis on alcohol consumption and factors influencing consumption.MethodsCross‐sectional online survey of 140 people (138 women) and interviews with 21 women diagnosed with breast cancer in the last 10 years.ResultsOf the 100 survey participants who drank alcohol 25% were drinking at increasing or higher risk levels and 17% strongly wanted to change their drinking behaviour. The habitual aspects of alcohol consumption were the strongest predictor of current alcohol consumption behaviours. Social norms and perceptions about conflicting information were substantial barriers to change.ConclusionsBreast cancer survivors need accurate information about the risks of alcohol consumption and guidelines in order to make informed decisions about making changes to their behaviour. Interventions to support breast cancer survivors to reduce alcohol consumption need to focus on the development of healthy habits and may benefit from a focus which includes partners and friends.
Bronchopulmonary dysplasia and diuretic use in an outpatient setting
Authors: McGlynn Julianne R. , Martin Amanda , Aoyama Brianna C. , Bamat Nicolas A. , Collaco Joseph M. , McGrath‐Morrow Sharon A. 
Published: August 2024

AbstractIntroductionDuring Neonatal Intensive Care Unit hospitalization, children born preterm with bronchopulmonary dysplasia (BPD) are frequently prescribed diuretics for chronic respiratory symptoms. However, less is known about diuretic use and weaning in an outpatient setting. The study sought to characterize clinical features associated with outpatient diuretic use and timing of diuretic weaning in children with BPD.MethodsData was obtained by chart review from 1224 registry participants born <32 weeks gestation, discharged between 2008 and 2023 and recruited from outpatient BPD clinics at Johns Hopkins Children's Center and the Children's Hospital of Philadelphia (97.4% diagnosed with BPD). Data was analyzed using Chi‐square tests, t‐tests, and ANOVA tests.ResultsChildren on diuretics at their first pulmonary visit (n = 737) were more likely to have lower birth weights, earlier gestational age, and severe BPD compared to those not on diuretics (n = 487). Of those prescribed diuretics, most children were on a thiazide alone (46.4%) or a thiazide and a potassium sparing agent (44.8%) with a minority prescribed loop diuretics alone (3.3%) or loop diuretic combinations (4.7%). Most children weaned off diuretics by 2 years of age. Public insurance, early gestational age, technology dependence, home supplemental oxygen use and loop diuretics were associated with slower diuretic weaning.ConclusionOutpatient diuretic use is common in children with BPD, however variations in diuretic use and diuretic combinations exist across centers. Time to wean off home supplemental oxygen is similar between children on one diuretic compared to none. Timing of outpatient diuretic weaning is influenced by diuretic class, respiratory support, and co‐morbidities.
luxA Gene From Enhygromyxa salina Encodes a Functional Homodimeric Luciferase
Authors: Yudenko Anna , Bazhenov Sergey V. , Aleksenko Vladimir A. , Goncharov Ivan M. , Semenov Oleg , Remeeva Alina , Nazarenko Vera V. , Kuznetsova Elizaveta , Fomin Vadim V. , Konopleva Maria N. , Al Ebrahim Rahaf , Sluchanko Nikolai N. , Ryzhykau Yury , Semenov Yury S. , Kuklin Alexander , Manukhov Ilya V. , Gushchin Ivan 
Published: August 2024

ABSTRACTSeveral clades of luminescent bacteria are known currently. They all contain similar lux operons, which include the genes luxA and luxB encoding a heterodimeric luciferase. The aldehyde oxygenation reaction is presumed to be catalyzed primarily by the subunit LuxA, whereas LuxB is required for efficiency and stability of the complex. Recently, genomic analysis identified a subset of bacterial species with rearranged lux operons lacking luxB. Here, we show that the product of the luxA gene from the reduced luxACDE operon of Enhygromyxa salina is luminescent upon addition of aldehydes both in vivo in Escherichia coli and in vitro. Overall, EsLuxA is much less bright compared with luciferases from Aliivibrio fischeri (AfLuxAB) and Photorhabdus luminescens (PlLuxAB), and most active with medium‐chain C4–C9 aldehydes. Crystal structure of EsLuxA determined at the resolution of 2.71 Å reveals a (β/α)8 TIM‐barrel fold, characteristic for other bacterial luciferases, and the protein preferentially forms a dimer in solution. The mobile loop residues 264–293, which form a β‐hairpin or a coil in Vibrio harveyi LuxA, form α‐helices in EsLuxA. Phylogenetic analysis shows EsLuxA and related proteins may be bacterial protoluciferases that arose prior to duplication of the luxA gene and its speciation to luxA and luxB in the previously described luminescent bacteria. Our work paves the way for the development of new bacterial luciferases that have an advantage of being encoded by a single gene.
Insecticidal activities of three recombinant venom proteins of the predatory stink bug, Arma custos
Authors: Wang Xinyi , Li Wenhong , Yang Xiang , Yang Mingwei , Gu Yucheng , Du Zhao , Yang Jingyi , Wen Mingxia , Park Yoonseong , Huang Chunyang , He Yueping 
Published: August 2024

AbstractBACKGROUNDWidespread resistance of insect pests to insecticides and transgenic crops in the field is a significant challenge for sustainable agriculture, and calls for the development of novel alternative strategies to control insect pests. One potential resource for the discovery of novel insecticidal molecules is natural toxins, particularly those derived from the venoms of insect predators.RESULTSIn this study, we identified three insecticidal proteinaceous toxins from the venom glands (VGs) of the predatory stink bug, Arma custos (Hemiptera: Asopinae). Transcriptomic analysis of A. custos VGs revealed 151 potentially secreted VG‐rich venom proteins. Three VG‐rich venom proteins (designated AcVP1 ~ 3) were produced by overexpression in Escherichia coli. Injection of the recombinant proteins into tobacco cutworm (Spodoptera litura) larvae showed that all of the three recombinant proteins caused paralysis, liquefaction and death. Injection of recombinant proteins into rice brown planthopper (Nilaparvata lugens) nymphs showed higher insecticidal activities, among which a trypsin (AcVP2) caused 100% mortality postinjection at 1.27 pmol mg−1 body weight.CONCLUSIONA natural toolkit for the discovery of insecticidal toxins from predatory insects has been revealed by the present study. © 2024 Society of Chemical Industry.
Contextual resources supporting the co‐evolution of teachers' collective inquiry and classroom practice after the grant ended
Authors: Shim Soo‐Yean , Thompson Jessica 
Published: August 2024

AbstractWe explored how various contextual resources accumulated over multiple years operated together to facilitate a team of high school teachers' sustained and agentive learning after a 4‐year research–practice partnership (RPP) grant concluded. Specifically, we examined constellations of resources that promoted the co‐evolution of the teachers' collective inquiry in the professional learning community (PLC) and classroom instruction, focused on supporting students' scientific explanations. We qualitatively analyzed the video/audio recordings of the PLC members' interactions in eight 75‐min PLC meetings (11 h) and a full‐day professional development (8 h) and classroom teaching (34 lessons) over the period of 6 months. We found that the contextual resources accumulated from the historical 4‐year RPP—including a culture of collaborative inquiry, collegial relationships, structures for teacher collaboration, and expertise embedded in individuals as well as co‐developed tools and practices (cultural, social, structural, and expertise resources)—were important. These resources, in combination with emerging teacher leadership (leadership resource) and timely supports, such as school leadership and district‐based funding for sustaining structures for collaboration (leadership and structural resources), enabled the teachers to launch and drive their own collaborative inquiry and shift instruction after the conclusion of the grant. The harmonized contexts led the teachers to learn across the PLC and classrooms by engaging in co‐evolution mechanisms—setting goals based on classroom data, reasoning about instructional practices using various representations of teaching, and experimenting on a set of common practices across classrooms. This paper is part of the special issue on Teacher Learning and Organizational Contexts.
Curcumin Analogues as Organic Fluorophores for Latent Fingerprint Imaging
Authors: Kush Durgi Nikita , N. Pavana , D. K. Ramesh , Pralhad Pujar Prasad 
Published: August 2024

AbstractSynthesis and characterization of two curcumin analogues BAA and Br‐AA via a condensation reaction was reported. Both the synthesized organic luminophores exhibited aggregation‐induced emission (AIE) with bright yellow and green emission respectively. Increase in the water% enhanced the emission by both the compounds confirmed the AIE property. A detailed study of latent fingerprints visualization was also carried out for both the analogues. Both the compounds showed good to normal capability to develop latent fingerprints (LFPs). Compound BAA performed better as a fluorescent material to develop LFPs compared to Br‐AA. The LFPs developed were analyzed to obtain 1–3 level of fingerprint patterns under UV 365 nm illumination. The LFPs developed using BAA exhibited excellent efficiency, sensitivity, high contrast with low background interreference. All three levels of fingerprint patterns were identified by BAA. However, Br‐AA showed inability to develop high clarity images of latent fingerprints. The solid‐state emission nature of the analogues was also evaluated from their emission spectra and CIE coordinates were found to be were (0,187, 0.518) and (0.265, 0.484) for BAA and Br‐AA respectively.
Imidazole‐Oxadiazole Hybrid as Potential Antimicrobial Agents: Design, Synthesis, Drug–Likeness, Pharmacophore and Molecular Docking Study
Authors: Reddy Anjanareddy Basava , Allaka Tejeswara Rao , Avuthu Vidya Sagar Reddy , Kishore Pilli V. V. N. , Nagarajaiah Honnappa 
Published: August 2024

AbstractA new series of imidazole linked 1,3,4‐oxadizoles were designed and synthesized from 2‐butyl‐4‐chloro‐1H‐imidazole‐5‐carbaldehyde (1) as a starting material. The synthesized compounds were characterized by well–known spectroscopic techniques, i. e., IR, 1H NMR, 13C NMR, and mass spectrometry. Against Gram–positive bacteria S. aureus, compounds 8 e, 8 i, and 8 k showed the highest antibacterial activity with diameter zone values 25±0.44, 25±0.65, 22±0.91 mm respectively. Compounds 8 e, 8 g, and 8 i are active against Gram–negative bacteria E. coli with ZI of 26±0.58, 21±0.51, 26±0.71 mm. Interestingly, the molecules 8 a, and 8 h were more selective towards antifungal activity against F. oxysporum (ZI=21±0.11, 21±0.51 mm), compared to clotrimazole (19±0.13 mm). The docking study results of compound 8 d formed highly stable H‐bonding with Asp‐89, Asn‐145, Val‐88, Arg‐144 amino acids, which are plays a crucial role in ensuring efficient binding of the ligand in a crystal structure of S. aureus mutated in GyrB ATPase domain (PDB: 3U2K). The study of computer aided ADMET was also carried out, using SwissADME, ADMETlab2.0 to investigate the pharmacokinetic properties of the tested triazole compounds.
Functionalized and Ag‐Loaded Nano‐Delivery System for Doxorubicin: Loading, Controlled Release and Kinetic Studies
Authors: Aydogdu Burcu , Kaplan Ince Olcay , Ince Muharrem , Unal Ilkay 
Published: August 2024

AbstractMulti‐walled carbon nanotubes (fMWCNTs) that functionalized and loaded Ag nanoparticles (AgNPs) were investigated to adsorp doxorubicin hydrochloride (DXR). DXR release behavior efficiency was determined using kinetic studies. DXR agent was treated into fMWCNTs@AgNPs material with different drug loading rates. The material was successfully established and characterized using transmission electron microscopy, and fourier transform–infrared spectroscopy. Thermogravimetric analysis was performed to elucidate the effect of temperature on mass loss and X‐ray diffraction analysis was systematically assessed the crystalline state of DXR. Various kinetic models including Higuchi, Baker Hixson‐Crowell, and power‐law were applied. It was revealed that DXR has more binding affinity to the fMWCNTs@AgNPs material system surface as a nanocarrier at pH 7.4 and showed more release at pH 5.0. Functionalized material confirmed its efficiency as pH‐based drug delivery system. Used material can be utilized as promising nanocarriers, and findings will contribute to the rational design of novel delivery tools for drugs.