bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models
Authors: Kulkarni Ajinkya , Ferreira Nathalia , Scodellaro Riccardo , Choezom Dolma , Alves Frauke 
Published: July 2024

AbstractTumor organoids are three-dimensional in vitro models which can recapitulate the complex mutational landscape and tissue architecture observed in cancer patients, providing a realistic model for testing novel therapies, including immunotherapies. A significant challenge in organoid research in oncology lies in developing efficient and reliable methods for segmenting organoid images, quantifying organoid growth, regression and response to treatments, as well as predicting the behavior of organoid systems. Up to now, a curated dataset of organoids co-cultured with immune cells is not available. To address this gap, we present a new public dataset, comprising both phase-contrast images of murine and patient-derived tumor organoids of one of the deadliest cancer types, the Pancreatic Ductal Adenocarcinoma, co-cultured with immune cells, and state-of-the-art algorithms for object detection and segmentation. Our dataset, OrganoIDNetData, encompassing 180 images with 33906 organoids, can be a potential common benchmark for different organoids segmentation protocols, moving beyond the current practice of training and testing these algorithms on isolated datasets.
Distribution and habitat database of fluvial Plecoptera, Trichoptera and Coleoptera from Sierra Nevada, Spain
Authors: López-Rodríguez Manuel Jesús , Ros-Candeira Andrea , Fajardo Merlo María del Carmen , Sáinz Bariáin Marta , Sainz-Cantero Caparrós Carmen Elisa , Tierno de Figueroa José Manuel , Zamora-Muñoz Carmen 
Published: July 2024

AbstractSierra Nevada (southern Iberian Peninsula) harbours a great biodiversity and the studies on some aquatic insect groups have been and continue to be numerous there. This database brings together information on Plecoptera, Trichoptera and Coleoptera inhabiting running waters of this mountain system above 800 m of altitude. It includes data on the number, life stage and sex of individuals as well as the available information on abiotic characteristics of their habitats. The dataset is composed of 1,718 sampling events carried out between 1901 and 2022 in approximately 60 different water bodies, 15,347 occurrences pertaining to more than 203,000 individuals, and 10,173 records of associated measurements (23 physico-chemical parameters). The dataset is the result of a comprehensive review of scientific literature and of integrating data from recent research projects and the Sierra Nevada Global-Change Observatory’s long-term monitoring data. This information is valuable for those studying past distributions and abundances of the species in the dataset, for building predictive models or just studying temporal trends in the current context of climate change.
Defining a core breath profile for healthy, non-human primates
Authors: Bobak Carly A. , Stevenson Keisean A. J. M. , Sun Ning , Khan Mohammad S. , Azmir Jannatul , Beccaria Marco , Tomko Jaime A. , Fillmore Daniel , Scanga Charles A. , Lin Philana L. , Flynn JoAnne L. , Hill Jane E. 
Published: July 2024

AbstractNon-human primates remain the most useful and reliable pre-clinical model for many human diseases. Primate breath profiles have previously distinguished healthy animals from diseased, including non-human primates. Breath collection is relatively non-invasive, so this motivated us to define a healthy baseline breath profile that could be used in studies evaluating disease, therapies, and vaccines in non-human primates. A pilot study, which enrolled 30 healthy macaques, was conducted. Macaque breath molecules were sampled into a Tedlar bag, concentrated onto a thermal desorption tube, then desorbed and analyzed by comprehensive two-dimensional gas chromatography-time of flight mass spectrometry. These breath samples contained 2,017 features, of which 113 molecules were present in all breath samples. The core breathprint was dominated by aliphatic hydrocarbons, aromatic compounds, and carbonyl compounds. The data were internally validated with additional breath samples from a subset of 19 of these non-human primates. A critical core consisting of 23 highly abundant and invariant molecules was identified as a pragmatic breathprint set, useful for future validation studies in healthy primates.
Sand mining deteriorates soil fertility and farming livelihoods around Accra, Ghana
Authors: Hemmler Katharina Salomea , Asare Kofi Yeboah , Tenkorang Emmanuel Yamoah , Buerkert Andreas 
Published: July 2024

AbstractUrbanization in Sub-Saharan Africa requires vast quantities of sand to meet infrastructural demands. In Accra, Ghana, sand mining occurs predominantly on farmlands at the city’s periphery. We selected three study communities to assess the effects of sand mining on agriculture using interviews with local farmers and soil analyses of mined and unmined fields. The results underscore the profound repercussions of sand mining on farmers, characterized by substantial agricultural land loss, the destruction of food crops, and the absence of compensation payments or land reclamation. The study further reveals a significant decline in soil fertility of mined fields compared to unmined fields as evidenced by reduced levels of carbon (C, by 6.3 g kg-1) and macronutrients (nitrogen (N, by 0.6 g kg-1), phosphorus (P, 12.7 mg kg-1), potassium (K, 77 mg kg-1) and magnesium (Mg, 88 mg kg-1)), and an increase in soil compaction (bulk density by 0.13 g cm-3 and penetration resistance by 0.11 MPa). Soil texture and pH were altered and sodium (Na, by 16 mg kg-1) and soil moisture (by 4%) increased. On a communal level, sand mining adversely affected water availability, road infrastructure, and the health of residents. The study fills research gaps on the effects of sand mining on agricultural productivity, soil fertility and livelihoods, emphasizing the urgent need for effective regulation, law enforcement and collaboration as well as compensation and land reclamation mechanisms to limit the adverse impacts of sand mining on ecosystem services. Further, the use of more sustainable building materials should be fostered to reduce the demand for sand in Ghana.
Soil conditions modify species diversity effects on tree functional trait expression
Authors: Davrinche Andréa , Haider Sylvia 
Published: July 2024

AbstractExamples of positive effects of biodiversity on ecosystem functions have kept accumulating in the last two decades, and functional traits are considered suitable tools to explain their underlying mechanisms. However, traits are rarely studied at the scale where these mechanisms (e.g., complementarity) are likely to originate, that is, between two interacting individuals. In an 18-month greenhouse experiment, we investigated how species diversity (i.e., monospecific or heterospecific tree pairs) affects within-individual leaf traits expression and variation and how this effect is modified by soil conditions. While resource addition through phosphorus fertilization partly strengthened the diversity effects, inoculation of soil microbiota (potentially leading to increased resource accessibility) resulted in counter effects. Hence, in contrast to our expectations, we did not find synergistic effects of the two soil treatments, but we found distinct effects on species following an acquisitive or conservative growth strategy. Overall, our study showed that the effect of species diversity on young trees’ adaptability and resource-use strategy needs to be considered alongside soil biotic and abiotic aspects. The influence of soil conditions on species diversity effects is essential to understand mechanisms behind complementarity at the individual level, which ultimately translate to the community scale.
Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer
Authors: Zhang Huicong , li yuhao , Lu Huixia 
Published: July 2024

AbstractThis study aimed to evaluate the expression and clinical significance of budding uninhibited by benzimidazole 1 (BUB1) and BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) in endometrial carcinoma (EC). BUB1 and BUBIB expressions were evaluated by bioinformatics. Protein expression, clinical features, prognosis and immune cell infiltration were explored in 20 EC tumors. siRNA was used to evaluate BUB1 and BUBIB function in EC cells. BUB1 and BUBIB were highly expressed in 26 cancers. BUB1 was associated with overall survival (OS) in eight cancers and disease-free survival in ten; BUB1B was associated with OS in nine cancers and DFS in eleven. BUB1 and BUBIB exhibited high frequencies of gene changes (mainly mutations, > 5%) in cancer. BUB1 was negatively correlated and BUB1B was positively correlated with cancer-associated fibroblasts and endothelial cell infiltration. BUB1 and BUBIB knockdown decreased migration and invasion in EC cells. High BUB1 expression correlated with tumor malignant phenotypes (P < 0.05). High BUB1 mRNA expression reduced OS (P = 0.00036) and recurrence-free survival (P = 0.0011). High BUB1B mRNA expression reduced OS (P = 0.0024). BUB1/BUB1B correlated with activated CD8 + T and CD4 + T cell infiltration. BUB1 and BUBIB are highly expressed and correlated with clinicopathological characteristics in EC. BUB1 and BUBIB are potential prognosis markers and immunotherapy targets.
A randomised controlled test in virtual reality of the effects on paranoid thoughts of virtual humans’ facial animation and expression
Authors: Wei Shu , Freeman Daniel , Harris Victoria , Rovira Aitor 
Published: July 2024

AbstractVirtual reality (VR) is increasingly used in the study and treatment of paranoia. This is based on the finding that people who mistakenly perceive hostile intent from other people also perceive similar threat from virtual characters. However, there has been no study of the programming characteristics of virtual characters that may influence their interpretation. We set out to investigate how the animation and expressions of virtual humans may affect paranoia. In a two-by-two factor, between-groups, randomized design, 122 individuals with elevated paranoia rated their perceptions of virtual humans, set in an eye-tracking enabled VR lift scenario, that varied in facial animation (static or animated) and expression (neutral or positive). Both facial animation (group difference = 102.328 [51.783, 152.872], p < 0.001, $${\eta }_{p}^{2}\hspace{0.17em}$$

η

p

2

= 0.125) and positive expressions (group difference = 53.016 [0.054, 105.979], p = 0.049, $${\eta }_{p}^{2}\hspace{0.17em}$$

η

p

2

= 0.033) led to less triggering of paranoid thoughts about the virtual humans. Facial animation (group difference = 2.442 [− 4.161, − 0.724], p = 0.006, $${\eta }_{p}^{2}\hspace{0.17em}$$

η

p

2

= 0.063) but not positive expressions (group difference = 0.344 [− 1.429, 2.110], p = 0.681, $${\eta }_{p}^{2}\hspace{0.17em}$$

η

p

2

= 0.001) significantly increased the likelihood of neutral thoughts about the characters. Our study shows that the detailed programming of virtual humans can impact the occurrence of paranoid thoughts in VR. The programming of virtual humans needs careful consideration depending on the purpose of their use.
Regression course of ostium granulomas under topical intranasal steroids coverage after endoscopic dacryocystorhinostomy
Authors: Ma Shang-Te , Shin Seonae , Navale Apurva , Woo Kyung In 
Published: July 2024

AbstractThis study aimed to elucidate the regression process of ostium granulomas under the usage of intranasal steroid after primary endoscopic dacryocystorhinostomy (DCR). The authors retrospectively reviewed 57 patients (a total of 72 ostia) who had ostium granulomas after primary endoscopic DCR between 2011 and 2015. Topical intranasal steroid spray was applied in all the patients since postoperative day 1. Adjunctive intralesional triamcinolone acetonide injections were administered for extensive and large-sized granulomas that caused impending ostium blockage. Sequential regression of the ostium granulomas and success rates of DCR were assessed using endoscopic photos. The granulomas completely disappeared in 69 (95.8%) ostia, and the average time interval from the surgery to the disappearance was 6.9 ± 2.8 months. Anatomical and functional surgical success rates were 90.3% and 84.7%, respectively. Intralesional steroid injections for ostium granulomas did not alter the outcomes compared to topical intranasal steroid usage significantly (p = 0.445). In conclusion, we observed that, by continuing the usage of intranasal steroids, ostium granulomas disappear gradually at postoperative 6 months. The intranasal surgical manipulation of granulomas, which results in more mucosal cicatricial change and impedes patient satisfaction, can be successfully avoided.
B cells secrete functional antigen-specific IgG antibodies on extracellular vesicles
Authors: Rival Claudia , Mandal Mahua , Cramton Kayla , Qiao Hui , Arish Mohd , Sun Jie , McCann James V. , Dudley Andrew C. , Solga Michael D. , Erdbrügger Uta , Erickson Loren D. 
Published: July 2024

AbstractB cells and the antibodies they produce are critical in host defense against pathogens and contribute to various immune-mediated diseases. B cells responding to activating signals in vitro release extracellular vesicles (EV) that carry surface antibodies, yet B cell production of EVs that express antibodies and their function in vivo is incompletely understood. Using transgenic mice expressing the Cre recombinase in B cells switching to IgG1 to induce expression of fusion proteins between emerald green fluorescent protein (emGFP) and the EV tetraspanin CD63 as a model, we identify emGFP expression in B cells responding to foreign antigen in vivo and characterize the emGFP+ EVs they release. Our data suggests that emGFP+ germinal center B cells undergoing immunoglobulin class switching to express IgG and their progeny memory B cells and plasma cells, also emGFP+, are sources of circulating antigen-specific IgG+ EVs. Furthermore, using a mouse model of influenza virus infection, we find that IgG+ EVs specific for the influenza hemagglutinin antigen protect against virus infection. In addition, crossing the B cell Cre driver EV reporter mice onto the Nba2 lupus-prone strain revealed increased circulating emGFP+ EVs that expressed surface IgG against nuclear antigens linked to autoimmunity. These data identify EVs loaded with antibodies as a novel route for antibody secretion in B cells that contribute to adaptive immune responses, with important implications for different functions of IgG+ EVs in infection and autoimmunity.
Intensification of Cr(VI) adsorption using activated carbon adsorbent modified with ammonium persulfate
Authors: Zahakifar Fazel , Dashtinejad Maryam , Sepehrian Hamid , Samadfam Mohammad , Fasihi Javad , Yadollahi Ali 
Published: July 2024

AbstractGranular activated carbon has been modified by ammonium persulfate as a new adsorbent for Cr(VI) adsorption from aqueous solutions. The adsorbent was characterized by nitrogen adsorption–desorption isotherm data and infrared spectroscopy. The impact of different factors, such as the initial pH level of the solution, time, temperature, ionic strength, and initial concentration of the Cr(VI) ion, on the adsorption efficiencies of the adsorbent has been studied by batch experiments. Kinetic studies and the adsorption thermodynamics of Cr(VI) with ammonium persulfate-modified activated carbon adsorbent were carefully studied. The results showed that the Cr(VI) adsorption follows a pseudo-second-order kinetic model and the adsorption reaction is endothermic and spontaneous. The adsorption isotherm was scrutinized, and the fitting results showed that the Langmuir model could well represent the adsorption process. The maximum adsorption capacity of Cr(VI) onto persulfate-modified activated carbon was 108.69 mg g−1. The research results showed that using persulfate-modified activated carbon adsorbent can greatly remove Cr(VI) from aqueous solutions.
Functionalization of PEDOT:PSS for aptamer-based sensing of IL6 using organic electrochemical transistors
Authors: Burtscher Bernhard , Diacci Chiara , Makhinia Anatolii , Savvakis Marios , Gabrielsson Erik O. , Veith Lothar , Liu Xianjie , Strakosas Xenofon , Simon Daniel T. 
Published: July 2024

AbstractHere we propose a strategy to functionalize poly(ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) based organic electrochemical transistors (OECTs) for sensing the inflammatory cytokine interleukin 6 (IL6). For this aim we use diazonium chemistry to couple 4-aminobenzoic acid to sulfonate moieties on the PSS, which can act as anchors for aptamers or other recognition elements (e.g., fluorescent, or redox probes). We investigated this approach with a commercial screen-printable PEDOT:PSS formulation but also studied the effect of PEDOT to PSS ratio as well as the amount of crosslinker in other PEDOT:PSS formulations. For screen printed OECTs, it was possible to distinguish between IL6 and bovine serum albumin (BSA) in buffer solution and detect IL6 when added in bovine plasma in the nanomolar range. Furthermore, functionalization of PEDOT:PSS formulations with higher PSS content (compared to the “standard” solutions used for OECTs) combined with frequency dependent measurements showed the potential to detect IL6 concentrations below 100 pM.
DRRN: Differential rectification & refinement network for ischemic infarct segmentation
Authors: Zhou Wenxue , Yang Wenming , Liao Qingmin 
Published: July 2024

AbstractAccurate segmentation of infarct tissue in ischemic stroke is essential to determine the extent of injury and assess the risk and choose optimal treatment for this life‐threatening disease. With the prior knowledge that asymmetric analysis of anatomical structures can provide discriminative information, plenty of symmetry‐based approaches have emerged to detect abnormalities in brain images. However, the inevitable non‐pathological noise has not been fully alleviated and weakened, leading to unsatisfactory results. A novel differential rectification and refinement network (DRRN) for the automatic segmentation of ischemic strokes is proposed. Specifically, a differential feature perception encoder (DFPE) is developed to fully exploit and propagate the bilateral quasi‐symmetry of healthy brains. In DFPE, an erasure‐rectification (ER) module is devised to rectify pseudo‐lesion features caused by non‐pathological noise through utilising discriminant features within the symmetric neighbourhood of the original image. And a differential‐attention (DA) mechanism is also integrated to fully perceive the differences in cross‐axial features and estimate the similarity of long‐range spatial context information. In addition, a crisscross differential feature reinforce module embedded with multiple boundary enhancement attention modules is designed to effectively integrate multi‐scale features and refine textual details and margins of the infarct area. Experimental results on the public ATLAS and Kaggle dataset demonstrate the effectiveness of DRRN over state‐of‐the‐arts.
Public event lobbying: how interest groups use seminars and conferences for political influence
Authors: Fredheim Nanna A. G. 
Published: July 2024

AbstractWhile interest groups frequently arrange seminars and conferences, the strategic use of public events for political influence has largely evaded scholarly scrutiny. Drawing on systematic, in-depth data from 49 interviews, quantitative event mapping and extensive ethnographic observation within the health field, this study proposes that public event lobbying serve two key purposes: first, to forward policy issues and -solutions directly to policy makers within a public, communicatively controlled setting, and second, to network with a broad range of issue stakeholders, including policy makers. By arranging public events, interest groups in practice construct non-institutional arenas for direct access which afford substantial control over how issues are presented, and by whom. Moreover, by physically assembling decision makers and issue stakeholders, public event lobbying directly or indirectly contributes to establish and strengthen policy communities. Theoretically, public event lobbying is proposed as a direct outsider lobbying strategy, which serve both short-term issue influence objectives and long-term capacity building for lobbying through the construction of supportive networks. While public event lobbying is applied across group types, the study finds that financial resources and inter-organizational cooperation are key determinants for event organizing.
David Singing at the End of the Psalter
Authors: Goff Matthew 
Published: July 2024

Abstract
This short chapter contains a succinct overview of Psalm 151, which is part of the biblical book of Psalms in the Eastern Orthodox tradition but is not in Catholic or Protestant Bibles. Ancient biblical manuscripts present this psalm as the end of the Psalter in various ways. The poem focuses on the figure of David as a young shepherd, singing while tending his sheep. A lengthy Psalms Scroll found among the Dead Sea Scrolls brought to light a lost ancient Hebrew version of the poem, which is substantially different from the better-known Greek version. The psalm’s placement at the end of the Psalms imbues the entire collection with an impression of Davidic authorship.
Forgotten Scripture
Authors: Goff Matthew 
Published: July 2024

Abstract
This chapter examines 1 Enoch and the book of Jubilees. These two books are in the Old Testament of the Ethiopian Orthodox Church. The Dead Sea Scrolls and early Christian literature demonstrate that both these texts had a degree of authoritative status in antiquity. 1 Enoch is a collection of five separate apocalyptic works attributed to Enoch, who is extolled as a legendary antediluvian sage. Enochic literature stresses that male angels came down to earth and slept with women who gave birth to horrendous giants, whose rampages triggered Noah’s flood (the watchers myth). The book of Jubilees is an extensive retelling of Genesis and part of Exodus. It claims to be a transcription of the revelation Moses received when on Mount Sinai. 1 Enoch and Jubilees indicate that texts considered to have scriptural status in antiquity encompassed a larger corpus of texts than the writings preserved in the Bible.
War Power
Authors: Gould Philip 
Published: July 2024

Abstract
War Power reconsiders the literature of the Civil War North in light of the transformation of the power of the federal state. While literary scholarship about the Civil War generally has focused on the rise of wartime nationalism, it looks particularly at how literary works engage the subjects of censorship, propaganda, and the reconfigured meanings of “loyalty” and “treason” at a time of political crisis. During the war the Lincoln administration shut down opposition newspapers, curtailed free expression and civil liberties protected by the US Constitution, and Lincoln suspended the writ of habeas corpus to deal with political dissenters and try to control public opinion. Early on in the war, he coined the phrase “war power” to describe the (presumed) powers to address this crisis, and his policies became controversial throughout the conflict. War Power considers literary production in this “total war” that radically changed the federal government’s (and its military’s) relation to traditional norms and spaces of private, domestic, and social life. Each chapter focuses on a major writer in the Civil War North’s engagement with questions of identity, affect, and affiliation: Could one love the Union as one loved home and family? What were the implications for literary expression in the midst of a political culture being reshaped by censorship and propaganda? The book’s final two chapters address the role and plight of African Americans in the Civil War and its aftermath, focusing particularly on African American military service as the supposed means by which racially disenfranchised Americans might become citizens.