bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accumulation of contaminants of emerging concern in food crops—part 1: Edible strawberries and lettuce grown in reclaimed water
Authors: Hyland Katherine C. , Blaine Andrea C. , Dickenson Eric R.V. , Higgins Christopher P. 
Published: May 2015

Abstract

Contaminants of emerging concern present in domestic waste streams include a highly diverse group of potentially biologically active compounds that can be detected at trace levels in wastewater. Concerns about potential uptake into crops arise when reclaimed water is used in food crop production. The present study investigated how 9 contaminants of emerging concern in reclaimed water are taken up into edible portions of two food crops. Two flame retardant chemicals, tris(1-chloro-2-propyl) phosphate (TCPP) and tris(2-chloroethyl) phosphate (TCEP) and several polar pharmaceuticals (carbamazepine, diphenhydramine, sulfamethoxazole, and trimethoprim) accumulated in a linear, concentration-dependent manner in lettuce (Lactuca sativa) irrigated with reclaimed water, suggesting passive uptake of both neutral and ionizable chemical contaminants in lettuce. Furthermore, concentration-dependent accumulation of TCEP and TCPP from reclaimed water was also observed in strawberry fruits (Fragaria ananassa). Collectively, these data suggest that highly polar or charged contaminants can be taken up by crops from water bearing contaminants of emerging concern and can be accumulated in the edible portions. Using these data, however, estimates of human exposure to these contaminants from reclaimed water food crop accumulation suggest that exposure to the contaminants of emerging concern examined in the present study is likely substantially lower than current exposure guidelines. Environ Toxicol Chem 2015;34:2213–2221. © 2015 SETAC
A pressure–velocity coupling approach for high void fraction free surface bubbly flows in overset curvilinear grids
Authors: Li Jiajia , Castro Alejandro M. , Carrica Pablo M. 
Published: May 2015

SummaryA methodology for improved robustness in the simulation of high void fraction free surface polydisperse bubbly flows in curvilinear overset grids is presented. The method is fully two‐way coupled in the sense that the bubbly field affects the continuous fluid and vice versa. A hybrid projection approach is used in which staggered contravariant velocities at cell faces are computed for transport and pressure–velocity coupling while the momentum equation is solved on a collocated grid arrangement. Conservation of mass is formulated such that a strong coupling between void fraction, pressure, and velocity is achieved within a partitioned approach, solving each field separately. A pressure–velocity projection solver is iterated together with a predictor stage for the void fraction to achieve a robust coupling. The implementation is described for general curvilinear grids detailing particulars in the neighborhood to overset interfaces or a free surface. A balanced forced method to avoid the generation of spurious currents is extended for curvilinear grids. The overall methodology allows simulation of high void fraction flows and is stable even when strong packing forces accounting for bubble collisions are included. Convergence and stability in one‐dimensional (1D) and two‐dimensional (2D) configurations is evaluated. Finally, a full‐scale simulation of the bubbly flow around a flat‐bottom boat is performed demonstrating the applicability of the methodology to complex problems of engineering interest. Copyright © 2015 John Wiley & Sons, Ltd.
Fiber heart valve prosthesis: Early in vitro fatigue results
Authors: Vaesken Antoine , Khoffi Foued , Heim Frederic , Dieval Florence , Chakfe Nabil 
Published: May 2015

AbstractTranscatheter aortic valve replacement has become today a largely considered alternative technique to surgical valve replacement in patients with high risk for open chest surgery. Biological valve tissue used in the transcatheter devices has shown success over 5 years now, but the procedure remains expensive. Moreover, different studies point out potential degradations that the tissue can undergo when folded to lower diameter and released in calcified environment with irregular geometry, which may jeopardize the durability of the device. The use of synthetic materials, like textile in particular, to replace biological valve leaflets would help reducing the procedure costs, and limit the degradations when the valve is crimped. Textile polyester material has been extensively used in the vascular surgery and is characterized by outstanding folding and strength properties combined with proven biocompatibility. However, the friction effects that occur between filaments and between yarns within a fabric under flexure loading could be critical for the resistance of the material on the long term. The purpose of this study was to assess the early fatigue performances of textile valve prototypes under accelerated cyclic loading up to 200 Mio cycles. Durability tests show that the fibrous material undergoes rearrangements between fibrous elements within the textile construction and the mechanical properties are modified on the long term. But testing is not complete with 200 Mio cycles. The material should be tested up to a higher number of cycles in future work to test the effective long‐term durability. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 986–992, 2016.
Artificial Zinc Finger DNA Binding Domains: Versatile Tools for Genome Engineering and Modulation of Gene Expression
Authors: Hossain Mir A. , Barrow Joeva J. , Shen Yong , Haq MD Imdadul , Bungert Jörg 
Published: May 2015

ABSTRACTGenome editing and alteration of gene expression by synthetic DNA binding activities gained a lot of momentum over the last decade. This is due to the development of new DNA binding molecules with enhanced binding specificity. The most commonly used DNA binding modules are zinc fingers (ZFs), TALE‐domains, and the RNA component of the CRISPR/Cas9 system. These binding modules are fused or linked to either nucleases that cut the DNA and induce DNA repair processes, or to protein domains that activate or repress transcription of genes close to the targeted site in the genome. This review focuses on the structure, design, and applications of ZF DNA binding domains (ZFDBDs). ZFDBDs are relatively small and have been shown to penetrate the cell membrane without additional tags suggesting that they could be delivered to cells without a DNA or RNA intermediate. Advanced algorithms that are based on extensive knowledge of the mode of ZF/DNA interactions are used to design the amino acid composition of ZFDBDs so that they bind to unique sites in the genome. Off‐target binding has been a concern for all synthetic DNA binding molecules. Thus, increasing the specificity and affinity of ZFDBDs will have a significant impact on their use in analytical or therapeutic settings. J. Cell. Biochem. 116: 2435–2444, 2015. © 2015 Wiley Periodicals, Inc.
Developing Creative Behavior in Elementary School Students with Robotics
Authors: Nemiro Jill , Larriva Cesar , Jawaharlal Mariappan 
Published: May 2015

AbstractThe School Robotics Initiative (SRI), a problem‐based robotics program for elementary school students, was developed with the objective of reaching students early on to instill an interest in Science, Technology, Engineering, and Math disciplines. The purpose of this exploratory, observational study was to examine how the SRI fosters student creative behavior. Weekly observations of 194 students (4th–6th grade) were conducted in three classrooms, over 3 years. Supplemental data were collected from student‐written journals. Data were coded for themes. The findings revealed that the robotics classrooms were characterized by a high degree of energy. The students worked intensely on robotic tasks, engaging in a two‐stage creative process that involved first designing a robot with a preplanned or spontaneous work approach, followed by an iterative period of trial and error creative programming. A variety of creativity techniques were observed being used. The SRI was shown to develop creative behavior in the students through the myriad of creative robot products generated. Based on the findings, the authors propose a componential model for developing creative behavior in the students through robotics, which includes a set of social, psychological, and physical elements necessary for the students to produce creative results in school robotics programs.
In‐vivo three‐dimensional knee kinematics during daily activities in dogs
Authors: Kim Stanley E. , Jones Stephen C. , Lewis Daniel D. , Banks Scott A. , Conrad Bryan P. , Tremolada Giovanni , Abbasi Abdullah Z. , Coggeshall Jason D. , Pozzi Antonio 
Published: May 2015

ABSTRACTThe canine knee is morphologically similar to the human knee and thus dogs have been used in experimental models to study human knee pathology. To date, there is limited data of normal canine 3D knee kinematics during daily activities. The objective of this study was to characterize 3D in‐vivo femorotibial kinematics in normal dogs during commonly performed daily activities. Using single‐plane fluoroscopy, six normal dogs were imaged performing walk, trot, sit, and stair ascent activities. CT‐generated bone models were used for kinematic measurement using a 3D‐to‐2D model registration technique. Increasing knee flexion angle was typically associated with increasing tibial internal rotation, abduction and anterior translation during all four activities. The precise relationship between flexion angle and these movements varied both within and between activities. Significant differences in axial rotation and coronal angulation were found at the same flexion angle during different phases of the walk and trot. This was also found with anterior tibial translation during the trot only. Normal canine knees accommodate motion in all planes; precise kinematics within this envelope of motion are activity dependent. This data establishes the characteristics of normal 3D femorotibial joint kinematics in dogs that can be used as a comparison for future studies. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1603–1610, 2015.
Rapid volumetric t1 mapping of the abdomen using three‐dimensional through‐time spiral GRAPPA
Authors: Chen Yong , Lee Gregory R. , Aandal Gunhild , Badve Chaitra , Wright Katherine L. , Griswold Mark A. , Seiberlich Nicole , Gulani Vikas 
Published: May 2015

PurposeTo develop an ultrafast T1 mapping method for high‐resolution, volumetric T1 measurements in the abdomen.MethodsThe Look‐Locker method was combined with a stack‐of‐spirals acquisition accelerated using three‐dimensional (3D) through‐time spiral GRAPPA reconstruction for fast data acquisition. A segmented k‐space acquisition scheme was proposed and the time delay between segments for the recovery of longitudinal magnetization was optimized using Bloch equation simulations. The accuracy of this method was validated in a phantom experiment and in vivo T1 measurements were performed with 35 asymptomatic subjects on both 1.5 Tesla (T) and 3T MRI systems.ResultsPhantom experiments yielded close agreement between the proposed method and gold standard measurements for a large range of T1 values (200 to 1600 ms). The in vivo results further demonstrate that high‐resolution T1 maps (2 × 2 × 4 mm3) for 32 slices can be achieved in a single clinically feasible breath‐hold of approximately 20 s. The T1 values for multiple organs and tissues in the abdomen are in agreement with the published literature.ConclusionA high‐resolution 3D abdominal T1 mapping technique was developed, which allows fast and accurate T1 mapping of multiple abdominal organs and tissues in a single breath‐hold. Magn Reson Med 75:1457–1465, 2016. © 2015 Wiley Periodicals, Inc.
Developing a Tailored Smoking Cessation Intervention for Rheumatoid Arthritis Patients
Authors: Aimer Pip , Stamp Lisa K. , Stebbings Simon , Cameron Vicky , Kirby Sandra , Croft Suzanne , Treharne Gareth J. 
Published: May 2015

AbstractPurposeSmoking is associated with an increased risk of comorbidities in rheumatoid arthritis (RA) and may reduce the efficacy of anti‐rheumatic therapies. Smoking cessation is therefore an important goal in RA. Our previous qualitative research identified five RA‐related barriers to smoking cessation: lack of support; limited knowledge of the relationship between smoking and RA; uncontrolled pain; inability to exercise; and using smoking as a coping strategy. The aim of this article is to describe the process of developing a smoking cessation intervention for RA patients based on these themes.MethodsA comprehensive review of the literature on smoking cessation was undertaken. A tailored smoking cessation programme was designed to address each RA‐specific barrier. A meeting was convened with key staff of Arthritis New Zealand to develop a consensus on feasible design to deliver a smoking cessation programme based on existing best practice and smoking cessation resources, and tailored within existing Arthritis New Zealand service delivery frameworks.ResultsA three‐month intervention was designed to be delivered by trained arthritis educators, with the following key components: nicotine replacement therapy for eight weeks; a telephone or face‐to‐face interview with each patient to determine their individual specific RA‐related barriers to smoking cessation; and individualized education and support activities which addressed these barriers. The intervention also included three follow‐up telephone calls; a support website; and 12 weekly smoking cessation advice emails.ConclusionsA RA‐specific smoking cessation invention was developed, matching support to specific issues within each patient's experience. A pilot study is in progress to evaluate the programme's efficacy. Copyright © 2015 John Wiley & Sons, Ltd.
Management of refractory chylothorax in pulmonary lymphangioleiomyomatosis
Authors: Ellender Claire M. , Williams Trevor J. , Gooi Julian , Snell Gregory I. , Whitford Helen M. 
Published: May 2015

AbstractThis case reports the successful management of chylothorax in a non‐transplanted patient with pulmonary lymphangioleiomyomatosis (pLAM). Prolonged initial therapy failed, including total parenteral nutrition, pleural drainage, surgical pleurodesis, and pleurectomy. Commencement of sirolimus 2 mg daily (2 mg alternating days had failed) led to resolution of chylothorax after 20 days. Discontinuation of sirolimus for abdominal surgery led to recurrence of the chylothorax. Reinstitution of sirolimus led to rapid resolution of the effusion, stabilization of lung function, and there has been no recurrence in the ensuing 4 years. We conclude that sirolimus should be considered in the management of pLAM‐related chylothorax, perhaps before surgical intervention.
Assessing Systemic Risk to Cloud‐Computing Technology as Complex Interconnected Systems of Systems
Authors: Haimes Yacov Y. , Horowitz Barry M. , Guo Zhenyu , Andrijcic Eva , Bogdanor Joshua 
Published: May 2015

ABSTRACTThis paper presents a methodology for modeling cloud‐computing technology (CCT), its users, and, most important, would‐be malicious intruders as complex interdependent and interconnected systems of systems (S‐o‐S). The paper posits and demonstrates that due to the inherent structure of CCT as S‐o‐S, users of public CCT are at a higher risk of unlawful intrusion than users of non‐CCT systems. At the same time, the flexibility and the agility of CCT S‐o‐S provide advantages relative to most non‐CCT S‐o‐S. The need is for the CCT community to employ these advantages as an integral part of its cyber security strategy. Our analysis builds on the following theory and methodology: we consider CCT and its users as complex interconnected hardware and software subsystems that interact as S‐o‐S through shared states, resources, and subsystems, which are connected in series (rather than in parallel, as is the case for most non‐CCT systems); exploiting the serial connectivity of CCT S‐o‐S, we use fault‐tree analysis to demonstrate the resulting unreliability of CCT S‐o‐S; building on the published literature, we incorporate Pareto‐optimal frontiers to compare the risks faced by security‐conscious users of CCT (e.g., large corporations) versus those faced by cost‐conscious users (e.g., small or startup companies); and we show that users of CCT as S‐o‐S are at a higher risk than users of non‐CCT systems for certain assumptions and types of cyber attacks. The paper is structured as follows: Part A outlines the characteristics of CCT S‐o‐S, addresses the inherent vulnerability of CCT S‐o‐S to cyber intrusion and attack, and provides a brief literature review; Part B offers a rationale for modeling CCT as interconnected and interdependent S‐o‐S; Part C demonstrates, through the use of fault‐tree analysis, the higher risk faced by CCT and its users as complex S‐o‐S; Part D presents an economic analysis of the security of CCT as S‐o‐S; and Part E offers conclusions and lessons learned.
Qualitative Exploration of an Effective Depression Literacy Fotonovela with at Risk Latina Immigrants
Authors: Hernandez Maria Y. , Organista Kurt C. 
Published: May 2015

AbstractWhile depression is prevalent among immigrant Latinas, mental health literacy is low. Culturally tailored health narratives can improve mental health literacy and are now increasingly featured in Spanish language fotonovelas (i.e., booklets in a comic book format with posed photographs and dialogue bubbles). The purpose of this qualitative study is to explore why a depression literacy fotonovela proved effective with Latina immigrants at risk for depression in a quantitative randomized control study. This study is the qualitative companion of the previously published quantitative piece of a mixed methods study, the latter revealing posttest improvements in depression knowledge, self‐efficacy to identify the need for treatment, and decreased stigma towards mental health care (Hernandez and Organista in Am J Community Psychol 2013. doi:10.1007/s10464‐013‐9587‐1). Twenty‐five immigrant Latinas participated in structured interviews, in the current qualitative study, 3 weeks after participating in the quantitative study. Results suggest depression literacy improved because participants evidenced high recall of the storyline and characters, which they also found appealing (e.g., liked peer and professional support offered to depressed main character). Further, identification with the main character was reflected in participants recalling similar circumstances impacting their mental health. Despite some improvement, stigma related to depression and its treatment remained for some women. Future research for the improvement of health literacy tools is discussed.
Experiences of Women Who Underwent Predictive BRCA 1/2 Mutation Testing Before the Age of 30
Authors: Brunstrom Kate , Murray Alexandra , McAllister Marion 
Published: May 2015

AbstractThis qualitative interview study focuses on the experiences of a sample of British female BRCA 1/2 carriers who had predictive testing before the age of 30, which is the minimum age for breast screening in the UK. Following appropriate informed consent procedures participants were recruited through the Cancer Genetics Service for Wales. Semi‐structured interviews were conducted face‐to‐face with seven participants, transcribed in full and analyzed using thematic analysis. The motives for testing and perceived advantages described by participants were similar to those identified in previous studies with older participants, such as increased awareness and knowledge and feeling more in control. However some of the perceived disadvantages were specific to younger women, including feeling pressured to make important life decisions earlier than they would have liked, such as about family planning and risk reducing surgery. Participants also reported feeling abandoned or forgotten because of lack of ongoing clinical contact, or feeling “stuck waiting” for screening to begin. However, none felt that these disadvantages were a reason to regret having testing. Findings in this small study suggest that having BRCA 1/2 predictive testing can have positive outcomes for young women even though they may be unable to access interventions such as breast screening. However it may be helpful to encourage young women during pre‐test counseling to explore the decisions and choices they may face. These young women could benefit from ongoing support and follow up and increased interaction with healthcare professionals.
Cyber victimization by peers: Prospective associations with adolescent social anxiety and depressive symptoms
Authors: Landoll Ryan R. , La Greca Annette M. , Lai Betty S. , Chan Sherilynn F. , Herge Whitney M. 
Published: May 2015

ABSTRACTPeer victimization that occurs via electronic media, also termed cybervictimization, is a growing area of concern for adolescents. The current study evaluated the short‐term prospective relationship between cybervictimization and adolescents' symptoms of social anxiety and depression over a six‐week period. Participants were 839 high‐school aged adolescents (14–18 years; 58% female; 73% Hispanic White), who completed measures of traditional peer victimization, cybervictimization, depression, and social anxiety at two time points. Findings supported the distinctiveness of cybervictimization as a unique form of peer victimization. Furthermore, only cybervictimization was associated with increased levels of depressive symptoms over time, and only relational victimization was associated with increased social anxiety over time, after controlling for the comorbidity of social anxiety and depression among youth. Cybervictimization appears to be a unique form of victimization that contributes to adolescents' depressive symptoms and may be important to target in clinical and preventive interventions for adolescent depression.
Relationships between perceived teachers' controlling behaviour, psychological need thwarting, anger and bullying behaviour in high‐school students
Authors: Hein Vello , Koka Andre , Hagger Martin S. 
Published: May 2015

ABSTRACTWe tested a model of the associations between students' perceptions of their physical education teacher's controlling behaviour, perceptions of basic psychological need thwarting, anger and bullying behaviour. School students (N = 602; M age = 12.88, SD = 1.37) from 10 schools completed measures of perceived teachers' controlling behaviour and perceived thwarting of the psychological needs for autonomy, competence, and relatedness in physical education context and self‐reported bullying and anger. A well‐fitting structural equation model demonstrated that students' perceptions of the negative conditional regard and intimidation exhibited by the teacher had significant indirect effect on students' feelings of anger and bullying behaviour through the perceived psychological need thwarting in physical education. Findings suggest that physical education teachers who avoid the use of negative conditional regard and intimidation in their classes have students who perceive less need thwarting and report less bullying behaviour.