bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clarifying the learning experiences of healthcare professionals with in situ and off-site simulation-based medical education: a qualitative study
Authors: Sørensen Jette Led , Navne Laura Emdal , Martin Helle Max , Ottesen Bent , Albrecthsen Charlotte Krebs , Pedersen Berit Woetmann , Kjærgaard Hanne , van der Vleuten Cees 
Published: October 2015

ObjectiveTo examine how the setting in in situ simulation (ISS) and off-site simulation (OSS) in simulation-based medical education affects the perceptions and learning experience of healthcare professionals.DesignQualitative study using focus groups and content analysis.ParticipantsTwenty-five healthcare professionals (obstetricians, midwives, auxiliary nurses, anaesthesiologists, a nurse anaesthetist and operating theatre nurse) participated in four focus groups and were recruited due to their exposure to either ISS or OSS in multidisciplinary obstetric emergencies in a randomised trial.SettingDepartments of obstetrics and anaesthesia, Rigshospitalet, Copenhagen, Denmark.ResultsInitially participants preferred ISS, but this changed after the training when the simulation site became of less importance. There was a strong preference for simulation in authentic roles. These perceptions were independent of the ISS or OSS setting. Several positive and negative factors in simulation were identified, but these had no relation to the simulation setting. Participants from ISS and OSS generated a better understanding of and collaboration with the various health professionals. They also provided individual and team reflections on learning. ISS participants described more experiences that would involve organisational changes than the OSS participants did.ConclusionsMany psychological and sociological aspects related to the authenticity of the learning experience are important in simulation, but the physical setting of the simulation as an ISS and OSS is the least important. Based on these focus groups OSS can be used provided that all other authenticity elements are taken into consideration and respected. The only difference was that ISS had an organisational impact and ISS participants talked more about issues that would involve practical organisational changes. ISS and OSS participants did, however, go through similar individual and team learning experiences.
Longitudinal qualitative exploration of cancer information-seeking experiences across the disease trajectory: the INFO-SEEK protocol
Authors: Germeni Evi , Bianchi Monica , Valcarenghi Dario , Schulz Peter J 
Published: October 2015

IntroductionΑ substantial corpus of literature has sought to describe the information-seeking behaviour of patients with cancer. Yet, available evidence comes mainly from cross-sectional studies, which provide ‘snapshots’ of patients’ information needs and information-seeking styles at a single time point. Only a few longitudinal studies currently exist; however, these are quantitative in nature and, despite successfully documenting changes in patients’ information needs throughout the clinical course of cancer, they have failed to provide an evidence-based interpretation of the causes and consequences of change. The goal of this study is threefold: First, we wish to provide a holistic understanding of how cancer information-seeking behaviour may evolve across different stages of the patient journey. Second, we will seek to elucidate the contextual and intervening conditions that may affect possible changes in information seeking. Third, we will attempt to identify what the consequences of these changes are, while heightening their implications for clinical practice and policy.Methods and analysisWe will carry out a longitudinal qualitative study, based on face-to-face, in-depth interviews with approximately 25 individuals diagnosed with cancer. Patients will be recruited from 2 oncology hospitals located in Ticino, Switzerland, and will be interviewed at 3 different time points: (1) within 2 weeks after receiving the cancer diagnosis; (2) within 2 weeks after their initial treatment; and (3) 6 months after their initial treatment. All interviews will be recorded and transcribed verbatim. A grounded theory approach will be used for the analysis of the data.Ethics and disseminationThe study protocol has been approved by the Ethics Committee of Canton Ticino (CE 2813). Participation in the study will be voluntary, and confidentiality and anonymity ensured. Prior to study participation, patients will be asked to provide signed informed consent. Findings will be disseminated in international peer-reviewed journals and presented in relevant conferences.
The EARN-Health Trial: protocol for a randomised controlled trial to identify health effects of a financial savings programme among low-income US adults
Authors: Basu Sanjay , Hamad Rita , White Justin S , Modrek Sepideh , Rehkopf David H , Cullen Mark R 
Published: October 2015

IntroductionA theory within the social epidemiology field is that financial stress related to having inadequate financial savings may contribute to psychological stress, poor mental health and poor health-related behaviours among low-income US adults. Our objective is to test whether an intervention that encourages financial savings among low-income US adults improves health behaviours and mental health.Methods and analysisA parallel group two-arm controlled superiority trial will be performed in which 700 participants will be randomised to the intervention or a wait list. The intervention arm will be provided an online Individual Development Account (IDA) for 6 months, during which participants receive a $5 incentive (£3.2, €4.5) for every month they save $20 in their account (£12.8, €18), and an additional $5 if they save $20 for two consecutive months. Both groups will be provided links to standard online financial counselling materials. Online surveys in months 0 (prior to randomisation), 6 and 12 (6 months postintervention) will assess self-reported health behaviours and mental health among participants in both arms. The surveys items were tested previously in the US Centers for Disease Control and Prevention national health interviews and related health studies, including self-reported overall health, health-related quality of life, alcohol and tobacco use, depression symptoms, financial stress, optimism and locus of control, and spending and savings behaviours. Trial data will be analysed on an intent-to-treat basis.Ethics and disseminationThis protocol was approved by the Institutional Review Board of Stanford University (Protocol ID: 30641). The findings of the trial will be disseminated through peer-reviewed publication.Trial registration numberIdentifierNCT02185612; Pre-results.
On singular limits arising in the scale analysis of stratified fluid flows
Authors: Feireisl Eduard , Klein Rupert , Novotný Antonín , Zatorska Ewelina 
Published: October 2015

We study the low Mach low Freude numbers limit in the compressible Navier–Stokes equations and the transport equation for evolution of an entropy variable — the potential temperature [Formula: see text]. We consider the case of well-prepared initial data on “flat” torus and Reynolds number tending to infinity, and the case of ill-prepared data on an infinite slab. In both cases, we show that the weak solutions to the primitive system converge to the solution to the anelastic Navier–Stokes system and the transport equation for the second-order variation of [Formula: see text].
A traffic model aware of real time data
Authors: Colombo Rinaldo M. , Marcellini Francesca 
Published: October 2015

Nowadays, traffic monitoring systems have access to real time data, e.g. through GPS devices. We propose a new traffic model able to take into account these data and, hence, able to describe the effects of unpredictable accidents. The well-posedness of this model is proved and numerical integrations show qualitative features of the resulting solutions. As a further motivation for the use of real time data, we show that the inverse problem for the Lighthill–Whitham and Richards (LWR) model is ill-posed.
Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases
Authors: Kai Kazuharu , Kondo Kimie , Wang Xiaoping , Xie Xuemei , Pitner Mary K. , Reyes Monica E. , Torres-Adorno Angie M. , Masuda Hiroko , Hortobagyi Gabriel N. , Bartholomeusz Chandra , Saya Hideyuki , Tripathy Debu , Sen Subrata , Ueno Naoto T. 
Published: October 2015

Abstract
Currently, no targeted drug is available for triple-negative breast cancer (TNBC), an aggressive breast cancer that does not express estrogen receptor, progesterone receptor, or HER2. TNBC has high mitotic activity, and, because Aurora A and B mitotic kinases drive cell division and are overexpressed in tumors with a high mitotic index, we hypothesized that inhibiting Aurora A and B produces a significant antitumor effect in TNBC. We tested this hypothesis by determining the antitumor effects of KW-2450, a multikinase inhibitor of both Aurora A and B kinases. We observed significant inhibitory activities of KW-2450 on cell viability, apoptosis, colony formation in agar, and mammosphere formation in TNBC cells. The growth of TNBC xenografts was significantly inhibited with KW-2450. In cell-cycle analysis, KW-2450 induced tetraploid accumulation followed by apoptosis or surviving octaploid (8N) cells, depending on dose. These phenotypes resembled those of Aurora B knockdown and complete pharmaceutical inhibition of Aurora A. We demonstrated that 8N cells resulting from KW-2450 treatment depended on the activation of mitogen-activated protein kinase kinase (MEK) for their survival. When treated with the MEK inhibitor selumetinib combined with KW-2450, compared with KW-2450 alone, the 8N cell population was significantly reduced and apoptosis was increased. Indeed, this combination showed synergistic antitumor effect in SUM149 TNBC xenografts. Collectively, Aurora A and B inhibition had a significant antitumor effect against TNBC, and this antitumor effect was maximized by the combination of selumetinib with Aurora A and B inhibition. Mol Cancer Ther; 14(12); 2687–99. ©2015 AACR.
Replicating Patient-Specific Severe Aortic Valve Stenosis With Functional 3D Modeling
Authors: Maragiannis Dimitrios , Jackson Matthew S. , Igo Stephen R. , Schutt Robert C. , Connell Patrick , Grande-Allen Jane , Barker Colin M. , Chang Su Min , Reardon Michael J. , Zoghbi William A. , Little Stephen H. 
Published: October 2015

Background—
3D stereolithographic printing can be used to convert high-resolution computed tomography images into life-size physical models. We sought to apply 3D printing technologies to develop patient-specific models of the anatomic and functional characteristics of severe aortic valve stenosis.

Methods and Results—

Eight patient-specific models of severe aortic stenosis (6 tricuspid and 2 bicuspid) were created using dual-material fused 3D printing. Tissue types were identified and segmented from clinical computed tomography image data. A rigid material was used for printing calcific regions, and a rubber-like material was used for soft tissue structures of the outflow tract, aortic root, and noncalcified valve cusps. Each model was evaluated for its geometric valve orifice area, echocardiographic image quality, and aortic stenosis severity by Doppler and Gorlin methods under 7 different in vitro stroke volume conditions. Fused multimaterial 3D printed models replicated the focal calcific structures of aortic stenosis. Doppler-derived measures of peak and mean transvalvular gradient correlated well with reference standard pressure catheters across a range of flow conditions (
r
=0.988 and
r
=0.978 respectively,
P
<0.001). Aortic valve orifice area by Gorlin and Doppler methods correlated well (
r
=0.985,
P
<0.001). Calculated aortic valve area increased a small amount for both methods with increasing flow (
P
=0.002).

Conclusions—
By combing the technologies of high-spatial resolution computed tomography, computer-aided design software, and fused dual-material 3D printing, we demonstrate that patient-specific models can replicate both the anatomic and functional properties of severe degenerative aortic valve stenosis.
Bursaphelenchus parantoniae n. sp. (Tylenchina: Aphelenchoididae) found in packaging wood from Belgium
Authors: Maria Munawar , Fang Yiwu , He Jie , Gu Jianfeng , Li Hongmei 
Published: October 2015

Bursaphelenchus parantoniaen. sp. isolated in Ningbo, China, from packaging wood made ofPinussp. imported from Belgium, is described. It is characterised by a slim body (a = 32.6-51), lateral field with two lines, excretory pore locatedcaone metacorpal length posterior to median bulb, spicules stout and arcuate with triangular rostrum and flattened cucullus, and seven caudal papillae arranged as a single midventral precloacal papilla, one adcloacal pair and two postcloacal pairs. The vagina is inclined anteriorly, a vulval flap is present, the post-uterine branch extends for more than half of the vulva-anus distance, and the female tail is conical with a hyaline region and bluntly rounded terminus. Phylogenetic analyses showed thatB. parantoniaen. sp. clusters with thehylobianum-group and appears close toB. antoniae,B. chengi,B. hylobianumandB. niphades. The new species is distinguished from these species by morphology, ITS-RFLP patterns and molecular characters.
Warm Organized Rain Systems over the Tropical Eastern Pacific
Authors: Chen Baohua , Liu Chuntao 
Published: October 2015

Abstract
This study uses 16-yr Tropical Rainfall Measuring Mission (TRMM) radar precipitation feature (RPF) data to characterize warm rain systems in the tropics with large horizontal extensions, referred to as warm organized rain systems. The systems are selected by specifying the RPFs with minimum infrared brightness temperature warmer than 0°C and rain area greater than 500 km2. ERA-Interim atmospheric fields and SST from NOAA are analyzed to highlight the environmental characteristics of warm organized rain systems.
Warm organized systems occur over specific oceanic regions, including the eastern Pacific ITCZ, the eastern part of the SPCZ, and coastal regions. In contrast with ubiquitous warm isolated RPFs, warm organized systems have greater near-surface radar reflectivity. The rainfall amounts generated by warm organized systems are greater in winter than in summer.
Composite analyses indicate that warm organized RPFs prefer to coexist with a dry midtroposphere associated with a strong upper-level descent, an enhanced near-surface moisture convergence, and a strong low-level large-scale ascent. The shallow meridional circulation in the eastern Pacific is significantly stronger for warm organized RPFs compared to the circulation for warm isolated RPFs. Warm organized systems over the tropical eastern Pacific occur at warm SSTs with mean value of about 27°C and a strong SST meridional gradient. The warm organized RPFs in the tropical eastern Pacific are found to be at the southern edge of deep ITCZ cores. This is probably related to the meridional asymmetrical thermodynamic structure over the eastern Pacific ITCZ with a higher low-level humidity to the south. Similar favorable large-scale environments for the warm organized RPFs are also found over the SPCZ and other regions.
Outcomes in Advanced Head and Neck Cancer Treated with Up‐front Neck Dissection prior to (Chemo)Radiotherapy
Authors: Elicin Olgun , Albrecht Tobias , Haynes Alan G. , Bojaxhiu Beat , Nisa Lluís , Caversaccio Marco , Dal Pra Alan , Schmücking Michael , Aebersold Daniel M. , Giger Roland 
Published: October 2015

ObjectiveOur aim was to compare outcomes with and without up‐front neck dissection prior to (chemo)radiotherapy in head and neck squamous cell carcinoma.Study DesignCase series with chart review.SettingTertiary referral center.Subjects and MethodsOutcomes of oropharyngeal, laryngeal, and hypopharyngeal squamous cell carcinoma cases with neck lymph node metastases treated from January 2001 to March 2012 were analyzed. Due to imbalances in baseline characteristics between groups treated with (n = 129) and without (n = 95) up‐front neck dissection, propensity score matching was performed.ResultsMedian follow‐up was 48 months (range, 12‐148). With up‐front neck dissection, the hazard ratio for the primary end point, disease‐free survival, was 0.63 (95% confidence interval: 0.37‐1.06, P =. 08). Up‐front neck dissection reduced acute grade ≥3 toxicity significantly when xerostomia was excluded (odds ratio: 0.40, 95% confidence interval: 0.20‐0.82, P =. 012).ConclusionOur results indicate less acute treatment toxicity without any significant difference in terms of oncologic outcome with up‐front neck dissection prior to (chemo)radiotherapy as compared with (chemo)radiotherapy alone. Well‐designed randomized trials are required to verify this result and further investigate the impact of this strategy on late toxicity and oncologic outcome.
Prevalence of primary headache disorders diagnosed according to ICHD-3 beta in three different social groups
Authors: Lebedeva Elena R , Kobzeva Natalia R , Gilev Denis , Olesen Jes 
Published: October 2015

Background The aim of our study was to estimate the one-year prevalence of primary headache disorders in three different social groups using the third edition beta of the International Classification of Headache Disorders (ICHD-3 beta). Material and methods The study population included a total of 3124 participants: 1042 students (719 females, 323 males, mean age 20.6, age range 17–40), 1075 workers (146 females, 929 males, mean age 40.4, age range 21–67) and 1007 blood donors (484 females, 523 males, mean age 34.1, age range 18–64). We used a semi-structured, validated face-to-face interview. Results The age-adjusted one-year prevalence of migraine in females was significantly higher ( p < 0.001) in students (41.9%) than in workers (19.2%) and blood donors (18.7%). Age-adjusted prevalence of migraine among males did not differ among the three groups: 4.5% in students, 4.9% in workers and 4.5% in blood donors. Age-adjusted prevalence of tension-type headache (TTH) among females was almost the same in students and blood donors (68.8% and 66.7%) but female workers had a lower prevalence of TTH (57%). Age-adjusted prevalence of TTH among males did not differ significantly between students and blood donors (55.8% and 58.1%) but male workers had a significantly lower ( p < 0.001) prevalence of TTH (30.7%). The prevalence of chronic headache in students (TTH and/or migraine) was 3% and of probable medication-overuse headache 3%, significantly more than in workers and blood donors. Conclusion Headache prevalence was high and differed markedly among the three social groups. It is important that headache epidemiology also focus on socially defined groups in order to target future preventive efforts.
Time to invest in developing community mental health services
Authors: O’Halloran Paul , O’Connor Nick 
Published: October 2015

Objectives: To report on the evaluation of publicly funded community mental health services in two New South Wales health districts. Methods: Qualitative and quantitative data from 28 publicly funded adult community mental health teams in two NSW health districts were gathered using structured interviews, benchmarking surveys, focus groups and online questionnaires. Results: The community mental health services studied lacked a coherent strategic and recovery oriented framework or model of care for service delivery. There was evidence of poor role definition at the team level, resulting in duplication and inefficiency. There were inadequate staffing levels for stated objectives, a lack of training and continuing education in evidence based intervention, poor consumer and family participation in service design, and no development and monitoring of meaningful outcome measures. Conclusions: This review and benchmarking study highlights the need for mental health policy implementation to be further supported with: development of a service delivery framework outlining essential components of a specialist community mental health system; operational guidance to enable effective team specialisation in accordance with research; investment in practitioner training to support the development of evidence based practice; and processes to ensure effective consumer and carer participation in developing recovery oriented services.
Posterior Talar Shifting in Mobile-Bearing Total Ankle Replacement
Authors: Usuelli Federico G. , Maccario Camilla , Manzi Luigi , Tan Eric W. 
Published: October 2015

Background: End-stage ankle osteoarthritis frequently involves multiplanar malalignment in both the coronal and the sagittal planes. Sagittal malalignment often includes anterior translation of the talus relative to the tibia. Restoration of the correct tibial and talar alignment is essential for the long-term survival of total ankle replacement. Methods: This study includes 66 consecutive patients who underwent total ankle arthroplasty with the Hintegra prosthesis from May 2011 to April 2014. There were 28 females (42.4%) and 38 males (57.6%) with a mean age of about 57 years (25-82 years). Patients were clinically and radiologically assessed preoperatively and at 2, 6, and 12 months postoperatively. Results: At 12 months postoperatively, there was a statistically significant increase in American Orthopaedic Foot & Ankle Society scores from 31.9 to 72.3. Range of motion significantly increased from 9.5 to 25.4 degrees. In addition, there was a statistically significant decrease in visual analog scale (VAS) pain score from 8.9 to 2.2. Furthermore, there was a significant increase in the Tibio-Talar ratio from 2 to 6 months postoperatively (34.6%-37.2%). Conclusions: This study demonstrated significant improvements in clinical and radiologic outcomes after Hintegra total ankle arthroplasty. Significant movement of the talus occurs within the first 6 months postoperatively. This may be the result of rebalancing of muscle and ligament forces after surgery. Level of Evidence: Level IV, case series.
Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies
Authors: Matthews Geoffrey M. , Mehdipour Parinaz , Cluse Leonie A. , Falkenberg Katrina J. , Wang Eric , Roth Mareike , Santoro Fabio , Vidacs Eva , Stanley Kym , House Colin M. , Rusche James R. , Vakoc Christopher R. , Zuber Johannes , Minucci Saverio , Johnstone Ricky W. 
Published: October 2015

Key Points
Genetic studies suggest HDAC3-selective suppression may prove useful for treatment of hematological tumors but will not induce apoptosis. Genetic and pharmacological cosuppression of HDAC1 with HDAC2 induces a potent pro-apoptotic response of tumor cells.
Integration of mental health into primary care in low- and middle-income countries: The PRIME mental healthcare plans
Authors: Lund Crick , Tomlinson Mark , Patel Vikram 
Published: October 2015

SummaryThis supplement outlines the development and piloting of district mental healthcare plans from five low- and middle-income countries, together with the methods for their design, evaluation and costing. In this editorial we consider the challenges that these programmes face, highlight their innovations and draw conclusions.