bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Response Optimization of Haynes-25 Using Taguchi Grey Relational Analysis with Die-Sinking Electric Discharge Machine
Authors: Pathan Abrarkhan M. , Kumar Abhishek , Badheka Vishvesh , Oza Ankit D. , Kumar Sandeep , Kumar Rahul 
Published: August 2024

Background:
The recent development of new and advanced materials has led to industry
experiments, innovation, and patents. As a result, various alloys were developed and implanted for
multiple applications in the space, automobile, chemical, steel, and manufacturing industries. Cobalt-
and nickel-based alloys have been designed to cater to high-temperature and oxidationresistance
alloys.

Objective:
Here, various literature reviews are investigated, and the machining of Haynes-25 is
done using an electrical discharge machine with an optimization technique of the L27 orthogonal selection
of Taguchi. The controllable input procedure constraints are Pulse On time (Ton), Duty factor
(Df), Current (I), Gap voltage (Vg), and Flushing pressure (Fp).

Methods:
The performance characteristics output parameters considered are material removal rate,
tool wear rate, and surface roughness values (Ra). Moreover, confirmation tests are conducted to
determine the percentage error of the predicted model.

Results:
The confirmation tests and results showed that the duty factor and current greatly influence
the M.R.R, E.W.R, and Ra machining performance. The optimized condition is obtained at the implementation
of the confirmation test and using the level of significance, i.e., A3B2C3D3E3, which
can be used for the patent with the value of M.R.R..R as 0.05702, E.W.R. of 0.0091, and Ra of 2.34.
Furthermore, regression models are developed to predict the material removal rate, tool wear rate,
and surface roughness.

Conclusion:
It is suggested that industries use these optimum conditions to lessen unused material
and raise the productivity of Haynes-25 Electrical Discharge Machining, which can be patented.
A Remote Oral Self-Care Behaviors Assessment System in Vulnerable Populations: Usability and Feasibility Study
Authors: LaVine Danielle , Greer Zara , Kim Jiyun , Kumar Santosh , Belin Thomas , Shetty Vivek 
Published: August 2024

Background
Preventative self-care can reduce dental disease that disproportionately burdens vulnerable populations. Personalized digital oral self-care behavioral interventions offer a promising solution. However, the success of these digital interventions depends on toothbrushing data collection e-platforms attuned to the needs and preferences of vulnerable communities.

Objective
The aim of this study is to assess the usability and feasibility of the Remote Oral Behaviors Assessment System (ROBAS), which has been adapted to address the unique requirements of socioeconomically disadvantaged minority individuals.

Methods
A cohort of 53 community-clinic participants, including 31 (58%) Latino and 22 (42%) Black individuals with no prior experience using electric toothbrushes, were recruited to use ROBAS, with planned assessments at baseline, 2 months, and 4 months. Beyond evaluating ROBAS’s technical performance, extensive feedback was gathered to gauge users’ experiences, viewpoints, and overall contentment. The System Usability Scale (SUS) served as a primary metric for assessing user satisfaction and acceptability.

Results
ROBAS exhibited largely reliable and consistent data-gathering capabilities. SUS scores (mean 75.6, SD 14.5) reflected participant contentment within a range of values for other commonly used digital devices and technologies. Among participants who answered questions about willingness to pay for ROBAS, 97% (30/31) indicated that they were willing to pay for ROBAS either as a one-time payment or as a subscription-based service. Additionally, 87.5% of participants expressed that they would endorse it to acquaintances. Most participants expressed no reservations about privacy; among those who expressed privacy concerns (n=20, 50%), the concerns included exposure of information (n=18, 45%), monitoring of brushing habits (n=12, 30%), and collection of information (n=14, 35%), although these concerns did not significantly correlate with specific participant traits. In qualitative terms, users valued ROBAS's ability to monitor brushing habits but called for refinements, especially in Wi-Fi and application connectivity. Recommendations for system improvements encompassed enhanced app functionality, individualized coaching, more comprehensive brushing data, and the addition of flossing activity tracking.

Conclusions
The research highlights ROBAS's promise as a digital platform for unobtrusively tracking daily oral self-care activities in marginalized communities. The system proved to be both feasible, as evidenced by its stable and accurate data capture of brushing behaviors, and user-friendly, as reflected by strong SUS scores and positive user feedback. Influential factors for its uptake included ease of learning and operation, and the feedback provided.
Digital Mental Health Interventions for Alleviating Depression and Anxiety During Psychotherapy Waiting Lists: Systematic Review
Authors: Huang Sijia , Wang Yiyue , Li Gen , Hall Brian J , Nyman Thomas J 
Published: August 2024

Background
Depression and anxiety have become increasingly prevalent across the globe. The rising need for treatment and the lack of clinicians has resulted in prolonged waiting times for patients to receive their first session. Responding to this gap, digital mental health interventions (DMHIs) have been found effective in treating depression and anxiety and are potentially promising pretreatments for patients who are awaiting face-to-face psychotherapy. Nevertheless, whether digital interventions effectively alleviate symptoms for patients on waiting lists for face-to-face psychotherapy remains unclear.

Objective
This review aimed to synthesize the effectiveness of DMHIs for relieving depression and anxiety symptoms of patients on waiting lists for face-to-face therapy. This review also investigated the features, perceived credibility, and usability of DMHIs during waiting times.

Methods
In this systematic review, we searched PubMed, PsycINFO, Cochrane, and Web of Science for research studies investigating the effectiveness of DMHIs in reducing either depression or anxiety symptoms among individuals waiting for face-to-face psychotherapy. The search was conducted in June 2024, and we have included the studies that met the inclusion criteria and were published before June 6, 2024.

Results
Of the 9267 unique records identified, 8 studies met the eligibility criteria and were included in the systematic review. Five studies were randomized controlled trials (RCTs), and 3 studies were not. Among the RCTs, we found that digital interventions reduced depression and anxiety symptoms, but the majority of interventions were not more effective compared to the control groups where participants simply waited or received a self-help book. For the non-RCTs, the interventions also reduced symptoms, but without control groups, the interpretation of the findings is limited. Finally, participants in the included studies perceived the digital interventions to be credible and useful, but high dropout rates raised concerns about treatment adherence.

Conclusions
Due to the lack of effective interventions among the reviewed studies, especially among the RCTs, our results suggest that waiting list DMHIs are not more effective compared to simply waiting or using a self-help book. However, more high-quality RCTs with larger sample sizes are warranted in order to draw a more robust conclusion. Additionally, as this review revealed concerns regarding the high dropout rate in digital interventions, future studies could perhaps adopt more personalized and human-centered functions in interventions to increase user engagement, with the potential to increase treatment adherence and effectiveness.
The Impact of Information Relevancy and Interactivity on Intensivists’ Trust in a Machine Learning–Based Bacteremia Prediction System: Simulation Study
Authors: Katzburg Omer , Roimi Michael , Frenkel Amit , Ilan Roy , Bitan Yuval 
Published: August 2024

Abstract

Background
The exponential growth in computing power and the increasing digitization of information have substantially advanced the machine learning (ML) research field. However, ML algorithms are often considered “black boxes,” and this fosters distrust. In medical domains, in which mistakes can result in fatal outcomes, practitioners may be especially reluctant to trust ML algorithms.

Objective
The aim of this study is to explore the effect of user-interface design features on intensivists’ trust in an ML-based clinical decision support system.

Methods
A total of 47 physicians from critical care specialties were presented with 3 patient cases of bacteremia in the setting of an ML-based simulation system. Three conditions of the simulation were tested according to combinations of information relevancy and interactivity. Participants’ trust in the system was assessed by their agreement with the system’s prediction and a postexperiment questionnaire. Linear regression models were applied to measure the effects.

Results
Participants’ agreement with the system’s prediction did not differ according to the experimental conditions. However, in the postexperiment questionnaire, higher information relevancy ratings and interactivity ratings were associated with higher perceived trust in the system (P<.001 for both). The explicit visual presentation of the features of the ML algorithm on the user interface resulted in lower trust among the participants (P=.05).

Conclusions
Information relevancy and interactivity features should be considered in the design of the user interface of ML-based clinical decision support systems to enhance intensivists’ trust. This study sheds light on the connection between information relevancy, interactivity, and trust in human-ML interaction, specifically in the intensive care unit environment.
Biological and molecular targets for targeted therapy in colorectal cancer (literature review)
Authors: Malovanna A.Yu. , Kolesnik O.P. , Zvirych V.V. , Trehub Ye.S. 
Published: August 2024

Colon and rectal cancer are often grouped together and generally classified as colorectal cancer (CRC), despite their different clinical behaviors and treatment needs. CRC accounts for approximately 10 % of all cancers and is the second cause of cancer death. Clinical manifestations of metastatic CRC occur in approximately 20 % of patients. About 50 % of patients with loca­lized disease will eventually develop metastases. Considerable effort has been made to uncover and investigate the mutational landscape of metastatic colorectal cancer. The effect of tumor location on patient survival and response to therapy has been shown in large clinical trials; understanding that the right colon has a different embryological origin and blood supply than the left colon and the rectum became one of the key factors in choosing an approach to diagnosis and treatment of two fundamentally different diseases of the same organ. However, the underlying tumor biology that explains these differences has also been systematically investigated. As a result, four consensus molecular subtypes were identified, which are based on the anatomical location and selection of molecular markers that can act as potential targets and be used to develop individual treatment methods for each patient. In fact, the molecular stratification on which the current treatment algorithm for metastatic colorectal cancer is based is a significant step for a broader clinical understanding of genetic profiling in order to implement more effective therapeutic approaches. This resulted in a significant improvement of metastatic colorectal cancer control and patient survival. In this review, we attempt to systematize the data and summarize current knowledge about clinical and molecular differences between right- and left-sided colon cancer, which improve the therapy for metastatic colorectal cancer in the era of precision medicine.
Гастроінтестинальні стромальні пухлини: сучасні особливості діагностики та лікування
Authors: Sorokin B.V. , Litvinenko O.O. , Dyadyk O.O. , Samusieva A.A. 
Published: August 2024

Гастроінтестинальні стромальні пухлини (GIST) — рідкісні злоякісні новоутворення шлунково-кишкового тракту, однак є найпоширенішим варіантом серед сарком. Більшість таких пухлин діагностується у шлунку (80 %), до 20 % припадає на тонку кишку. Лікування пацієнтів з гастроінтестинальними стромальними пухлинами зазнало значних змін з появою інгібіторів тирозинкінази, які пригнічують тирозинкінази c-KIT та рецептор тромбоцитарного фактора росту альфа. Цей огляд охоплює аспекти ведення пацієнтів з гастроінтестинальними стромальними пухлинами, а саме користь неоад’ювантної та ад’ювантної системної терапії для пацієнтів з такими пухлинами, а також особливості виконання хірургічних втручань у пацієнтів з метастатичними ураженнями та без них. Поліпшилась терапія хворих з поширеними та метастатичними GIST завдяки застосуванню нових тирозинкіназних інгібіторів і хворих з визначеними драйверними мутаціями при «дикому» типі GIST. Чітко визначене поняття іматиніб-нечутливих GIST. Завдяки комплексному підходу до лікування можливе поліпшення прогнозу захворювання та досягнення тривалої ремісії у пацієнтів з метастатичним перебігом.
Improvement of Bixin Carotenoid Stability through the Formation of M–bixin (M = Mg<sup>2+</sup>, Ca<sup>2+</sup>, Zn<sup>2+</sup>, and Se<sup>4+</sup>) Complex Compounds Based on Photodegradation Kinetic Studies
Authors: Rahmalia Winda , Shofiyani Anis , Kusuma Dewi Yohana Sutiknyawati , Indriani Fani , Putri Alintianni Yolla , Septiani Septiani 
Published: August 2024

Bixin is used in wide-ranging food applications but is susceptible to degradation by many factors, including light. This research aims to increase bixin photostability through metal complexation. Bixin was complexed with Mg2+, Ca2+, Zn2+, and Se4+. The synthesis process was carried out in deep eutectic solvent media. Metal-bixin complexes have been successfully synthesized, indicated by the change in retention factor and %III/II ratio values resulting from thin-layer chromatography and UV-vis spectrophotometer analysis, respectively. The Fourier transform infrared analysis showed the interaction between central metal ion with bixin ligand has occurred by hydroxyl and carbonyl groups of bixin, which was characterized by a decrease in the intensity of the absorption peak in wavenumber 3000–4000 cm−1 (for the –OH carboxylic group vibration) and the peak shift of metal-bixin complexes towards the larger compared to bixin in the range wavenumber 1600–1700 cm−1 (for C=O ester vibrations). First-order photodegradation kinetics studies showed that the metal-bixin complexes were more stable than pure bixin. Se-bixin was four times more stable than pure bixin. Complexation of bixin with metals was shown to be a potential method to increase the stability of bixin, especially against light exposure.
FiberCreme Addition in Rice Increases the Dietary Fiber, Resistant Starch and Decreases Glycemic Index
Authors: Fibri Dwi Larasatie Nur , Marsono Yustinus 
Published: August 2024

A study on the addition of FiberCreme in cooking of rice has been conducted. The aim was to evaluate the effect of adding FiberCreme when cooking rice on chemical composition, dietary fiber and resistant starch of cooked rice as well as the glycemic index of rice with FiberCreme added. FiberCreme is a non-dairy creamer composed of coconut oil as the source of fat and dietary fiber as source of carbohydrate substituting sucrose in the traditional creamer. FiberCreme with different fiber sources were used including isomalto oligosaccharides (FC01), inulin (FC05) and isomaltodextrin (FC14). The FiberCreme added was 12% of weight of the rice grain. The addition of FiberCreme in cooked rice increase the total fat content from 0.33% (control rice) to 3.17%-3.33% (FiberCreme rice) but decrease the total carbohydrates content to 89.18%-89.43%, the total dietary fiber increase by 5.18%, 2.76% dan 4.5% in FC01, FC05 and FC14, respectively, and the resistant starch increase from 3.40% (control rice) to 5.11% (FC01 rice), 5.21% (FC05 rice) and 4.92% (FC14 rice), respectively. In human studies, it showed that addition of FiberCreme decrease the Glycemic Index (GI) of FiberCreme added cooked rice to 73.8 (FC01 rice), 70.7 (FC05 rice) and 76.5(FC14 rice) compared to 79.8 (control rice).
THE EFFECT OF PROBLEM BASED ELECTRONIC WORKSHEET WITH PROBLEM-BASED LEARNING MODEL ON STUDENT COMPETENCE ACHIEVEMENT IN PHYSICS LEARNING CLASS X SMAS ADABIAH 1 PADANG
Authors: Armanda Berliana Putry , Putra Amali 
Published: August 2024

In the achievement of students' have at physics competence, it is seen that has not shown optimal results. The causative factor at the learning process students is not active. This condition has happen because students not accustomed to problem soling at physics problems, the teacher is not have any more for giving instructions in the problem solving for physics problems, and lass motivation for students to take part in physics learning at class. Learning physics requires must have resources for learning that all needs for students, one of which is teaching materials. The teaching materials is teaching materials that can make improve student competence in the form of Student Worksheets (LKPD) based problem with problem-based learning models with the advantage by using electronic worksheet. This study aims to determine the effect of problem-based electronic worksheet with problem-based learning model on the physics competency achievement of class X MIPA SMAS Adabiah 1 Padang. This type of research is Quasi Experiment Design with a Randomized Group Only Design. The research population was class X MIPA SMAS Adabiah 1 Padang in the 2022/2023 academic year. The analysis obtained two sample classes are X MIPA 1 and 4. problem-based electronic worksheet with problem-based learning model as for experimental class and X MIPA 4 as a control class using by LKPD at school. The instrument used for knowledge competence is a written test which has been refined through trials and competency skills by assessing student performance. The data obtained was trials and analyzed statistically. The results of the study for both aspects of competency show that classes using electronic worksheet based problem have an average score higher than classes that do not use problem-based electronic worksheet with problem-based learning model. The results of the statistical tests performed showed differences as seen from the data descriptions of the two classes with a significant level of 0.05. The tvalue > ttable , so that it can be concluded that by using the problem-based electronic worksheet students' competence will be better. The effect of the influence exerted by the problem-based electronic worksheet with problem-based learning model on the achievement of students' physics knowledge and skill competencies, respectively, is 65.02% and 73.26%.
PENGARUH LINGKUNGAN KERJA, MOTIVASI KERJA, DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PADA PT GRIYA RESIK MANDIRI SURABAYA
Authors: Agusta Dos Santos  
Published: August 2024

Penelitian ini bertujuan untuk mengetahui beberapa faktor yang dapat mempengaruhi Kinerja Karyawan yaitu Lingkungan Kerja, Motivasi Kerja dan Disiplin Kerja. Lingkungan kerja adalah kondisi yang ada di sekitar tempat kerja. Motivasi Kerja adalah dorongan kebutuhan dan keinginan individu menuju tujuan tercapainya kepuasan dari apa yang dibutuhkan. Disiplin Kerja adalah suatu alat yang dipergunakan para manajer untuk berkomunikasi dengan karyawan agar mereka bersedia untuk mengubah suatu perilaku sebagai suatu upaya untuk meningkatkan kesadaran dan kesediaan seseorang dalam memenuhi segala peraturan perusahaan dan norma-norma sosial yang berlaku. Metode yang digunakan adalah metode analisis deskriptif kuantitatif.
Adanya penelitian ini diharapkan mampu menunjukkan bahwa penyelarasan faktor kinerja karyawan perlu terus dikembangkan agar mampu meningkatkan kinerja karyawan. Karena dengan karyawan yang bekerja dengan baik maka perusahaan akan lebih muda dalam mencapai visi dan misinya.
Dari hasil penelitian analisis regresi linear berganda diperoleh nilai konstanta sebesar 1.145 dan nilai koefisien regresi pada variabel lingkungan kerja sebesar 0.155, nilai koefisien regersi pada variabel motivasi kerja sebesar 0.189 sedangkan nilai koefisien regresi pada variabel disiplin kerja sebesar 0.421. Nilai koefisien determinasi adjusted R Square sebesar 0.588 menunjukan sekiat 58,8% memberikan hasil yang baik sehingga sisanya 41,2% dapat dijelaskan oleh variabel lain. Hasil uji t variabel lingkungan kerja terhadap variabel kinerja karyawan adalah 0.000 < 0.05 dan nilai t hitung 5.156 > t tabel 2.012 hipotesisnya diterima, uji t variabel motivasi kerja terhadap variabel kinerja karyawan adalah 0.000 < 0.05 dan nilai t hitung 5.321 > t tabel 2.012 hipotesisnya diterima, hasil uji t variabel disiplin kerja terhadap variabel kinerja karyawan adalah 0.000 < 0.05 dan nilai t hitung 7.326 > t tabel 2.012 hipotesinya diterima. Hasil nilai signifikan dari uji F (simultan) pada variabel lingkungan kerja, motivasi kerja, disiplin kerja terhadap kinerja karyawan adalah 0.000 < 0.05 dan nilai F hitung 24.355 > F tabel 2.810 hipotesisnya diterima.
Efficacy of Piroxicam and Tramadol for Relieving Pain Associated with Therapeutic Dental Extractions followed by Immediate Archwire Loading during Orthodontic Treatment: A Cross-Over Randomized Clinical Trial
Authors: Tiwari Aditi , Jain Madhu Sweta , Sawant Hitesh Ramdas , Gangurde Parag Vishnu , Kharkar Viraj Rajeev , Kalsi Harjit Singh , Sachdev Sanpreet Singh 
Published: August 2024

Objectives:
Extraction of premolars and archwire loading during orthodontic treatment is associated with postoperative pain that affects the patient’s quality of life and acceptability for the treatment. Prompt management of post-operative pain can improve patient’s compliance and confidence in the dental profession.

Material and Methods:
The present split-mouth double-blinded randomized clinical trial was conducted on 30 patients undergoing bilateral maxillary first premolar extraction followed by archwire placement for orthodontic treatment. Patients were administered either of the two drugs, tramadol or piroxicam, and their pain levels were recorded by visual analog scale at 2-hours (h), 4-h, and 6-h intervals. The same protocol was repeated for extraction of the contralateral premolar 1 week later, and the patients were provided with the other drug not received during the first extraction, followed by an assessment of the pain levels.

Results:
The pain levels were significantly higher (P < 0.01) at 2 h in the patients taking piroxicam as compared to 4-h and 6-h intervals. There was a significant rise in pain at the 4- and 6-h intervals compared to the 2-h interval following the administration of tramadol. The pain levels were significantly higher (P < 0.01) in the piroxicam group at the 2-h and 4-h intervals as compared to patients in the tramadol group. On the contrary, when considering the pain levels at the 6-h intervals, the pain levels were found to be significantly lower for patients administered with piroxicam.

Conclusion:
The use of piroxicam for the management of pain following the extraction and archwire placement during orthodontic treatment is more beneficial than the use of tramadol due to the sustenance of its effect over a prolonged duration of time.