bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Dementia and Cognitive Impairment in East Africa Region: A Scoping Review of Population-Based Studies and Call for Further Research
Authors: Yenesew Muluken A. , Krell-Roesch Janina , Fekadu Betelhem , Nigatu Dabere , Endalamaw Aklilu , Mekonnen Alemtsehay , Biyadgie Mulugeta , Wubetu Gizachew Y. , Debiso Alemu T. , Beyene Kassu M. , Kelkile Teshome S. , Enquobahrie Daniel A. , Mersha Tesfaye B. , Eagan Danielle E. , Geda Yonas E. 
Published: July 2024

Background: Population-based research on the prevalence and determinants of dementia, Alzheimer’s disease, and cognitive impairment is scarce in East Africa. Objective: To provide an overview of community- and population-based studies among older adults on the prevalence of dementia and cognitive impairment in East Africa, and identify research gaps. Methods: We carried out a literature search using three electronic databases (PubMed, Scopus, Google Scholar) using pertinent search terms. Results: After screening 445 publications, we identified four publications on the population-based prevalence of dementia, and three on cognitive impairment. Prevalence rates varied from 6– 23% for dementia, and 7– 44% for cognitive impairment, among participants aged≥50–70 years. Old age and a lower education level were risk factors for dementia and cognitive impairment. Physical inactivity, lack of a ventilated kitchen, and history of central nervous system infections and chronic headache were associated with increased odds of dementia. Female sex, depression, having no spouse, increased lifetime alcohol consumption, low income, rural residence, and low family support were associated with increased odds of cognitive impairment. Potential misclassification and non-standardized data collection methods are research gaps that should be addressed in future studies. Conclusions: Establishing collaborative networks and partnering with international research institutions may enhance the capacity for conducting population-based studies on dementia and cognitive impairment in East Africa. Longitudinal studies may provide valuable insights on incidence, as well as potential risk and protective factors of dementia and cognitive impairment, and may inform the development of targeted interventions including preventive strategies in the region.
Functional regulation of hydroxyproline, ascorbic acid and lipid peroxidation during GABA chitosan nanoparticles mediated liver regeneration
Authors: Shilpa J. , Nebu G.T. 
Published: July 2024

BACKGROUND: Liver is a vital organ and the role of Gamma aminobutyric acid (GABA) conjugated chitosan nanoparticles in enhancing the hepatocyte proliferation was reported. To understand the influence of these nanoparticles on various biochemical parameters during enhanced liver regeneration will improve its clinical significance. OBJECTIVE: To highlight the influence of GABA chitosan nanoparticles on ascorbic acid, hydroxyproline and lipid peroxidation levels during liver regeneration. METHODS: Intraperitoneal administration of nanoparticles was done to partially hepatectomised female Sprague Dawley rats (GCNP) and compared the biochemical parameters with sham operated control (C) and with no treatment (PHNT) cases. RESULTS: The hydroxyproline content was increased in the liver of GCNP when compared to PHNT ( P < 0.05). The lipid peroxidation level was increased ( P < 0.01) in PHNT compared to the control whereas, decreased in GCNP when compared ( P < 0.01) with PHNT. There was a significant increase ( P < 0.01) in the ascorbic acid content in PHNT when compared with C. It was significantly decreased ( P < 0.01) in GCNP when compared with PHNT. CONCLUSION: This highlighted the therapeutic implications of lipid peroxidation, hydroxyproline and ascorbic acid in GABA chitosan nanoparticles mediated liver regeneration, which will have immense clinical relevance in maintaining liver health.
How Information Affects Patients with Parkinson’s Disease: A Scoping Review of the Literature
Authors: Kurpershoek Elisabeth , Visser Leonie N.C. , Malekzadeh Arjan , de Bie Rob M.A. , Dijk Joke M. , Hillen Marij A. 
Published: July 2024

Background: Patients with Parkinson’s disease (PD) need to receive adequate information to manage their disease. However, little is known about how information provision affects patients. Objective: To conduct a scoping review of the literature on the relationship between content, timing, manner of delivery, and source of PD-specific information on the one hand, and patient outcomes on the other. Methods: All literature reporting about original data and published until April 2024 in peer-reviewed journals was searched in MEDLINE (Ovid), Embase (Ovid) and PsychInfo (Ovid). Subsequently, data were extracted and synthesized. Results: 40 publications describing the effects of information provision or patients’ evaluation thereof were retrieved. Four categories of patient outcomes were described, namely 1) evaluation and experience of information provision; 2) physical functioning; 3) psychosocial well-being; and 4) quality of life. In intervention studies, patients generally valued the provided information. Findings from cross-sectional and qualitative studies showed the importance of tailoring information to individuals’ needs and capabilities. Due to variation in study designs and outcomes, no unambiguous conclusions could be drawn regarding the relationship between information and outcomes. Conclusions: This scoping review identified how PD patients acquire information and revealed a lack of systematic research into the effect of information on patient outcomes. Future studies should assess 1) what information is currently provided by clinicians; 2) what additional information might be beneficial to provide; and 3) how information can be effectively aligned to benefit patients. This will eventually yield insight into how information might optimally empower PD patients.
Meta-Analysis: Impact of Sustainable Development on Pedagogical Approaches in Education
Authors: Hafeez Rabia , Muhammad Akram Tayyaba , Nazir Asim 
Published: July 2024

Sustainable development in education system can lead towards an innovative and productive world. In this study, meta-analytical approach is used to provide key themes of education for sustainable development (ESD), its basic competencies, and pedagogies. The main agenda of ESD is to achieve the goals of sustainable development (SD) by 2030. This review article focuses on an educational perspective that strengthens the educational institutions and empowers all the stakeholders. The current study shows the practices of last ten years to manifest that sustainable development is a significant tool in education. The primary focus of SD is to ensure advancement in the field of skill development. By following this process, teaching becomes constructive and meaningful. In this study, the meta-analysis research method is followed, reporting the analysis of more than sixty (60) research articles. The results and findings were interpreted through a screening process. The results showed that there is a positive and significant effect of sustainable development in the domain of education. Therefore, ESD competencies and pedagogies validate the performance of teachers, students, and all the stakeholders who desire to attain expertise in their respective practices.
Bunga Rampai Digital Sebagai Media Peningkatan Kompetensi Diri Dalam Komunikasi Dakwah Bagi Ikatan Mahasiswa Muhammadiyah
Authors: Susanti Ari , Angraeni Astri Widyarulli , Mukaromah Naimatul , Devananda Gede , Roji M. Ainur 
Published: July 2024

Produksi bunga rampai digital merupakan salah satu upaya menggerakkan Ikatan Mahasiswa Muhammadiyah (IMM) dengan cara meningkatkan kompetensi diri yang disesuaikan dengan hasrat generasi Z. Pengabdian ini diawali pelatihan pembuatan bunga rampai digital kemudian dilanjutkan dengan produksi sebagai implementasi hasil pelatihan. Tujuan produksi bunga rampai digital ini agar IMM memiliki karya inovatif dan kreatif untuk menunjang kegiatan-kegiatan keagamaan, kemahasiswaan dan kemasyarakatan seperti media promosi, media dakwah, media aktualisasi diri dan catatan sejarah IMM secara digital. Proses pembuatan bunga rampai digital ini memerlukan waktu kurang lebih 4 bulan. Proses pembuatan bunga rampai digital ini ada tema besar, yaitu (1) Kiprah IMM, (2) Senior IMM Turun Gunung, dan (3) Film Pendek Serba Serbi Dakwah IMM. Produksi 3 tema ini menjadi tonggak IMM yang senantiasa beradaptasi menyesuaikan selera generasi Z dan selalu berinovasi dalam penegakkan dakwah Al Islam dan Kemuhammadiyahan melalui digitalisasi media di era 5.0. Diharapkan, produksi bunga rampai digital ini mampu menjadi jawaban untuk pengembangan kaderisasi di Ikatan Mahasiswa Muhammadiyah.
Implementasi Progressive Web Apps Pada Platform Freelance Digital Dengan Metode Rapid Application Development
Authors: Saputra Reyhan Adi , Kautsar Irwan Alnarus , Ariyanti Novia , Aurusta Cindy 
Published: July 2024

Dalam beberapa tahun belakangan ini, jumlah freelancer di Indonesia telah meningkat secara signifikan. Banyak orang memilih menjadi freelancer karena mereka bisa bekerja dengan waktu yang lebih fleksibel, memiliki potensi penghasilan yang lebih besar, dan lebih memiliki kendali atas pekerjaan yang mereka lakukan. Freelancer juga dapat memberikan pekerjaan terhadap mitra di platform freelance digital ketika orderan menumpuk dan tidak dapat ditangani sendiri. Platform freelance digital menyediakan ruang dimana mitra dan freelancer dapat terhubung secara fleksibel melalui website, akan tetapi untuk mengunjungi Uniform Resource Locator (URL) website dilakukan secara berulang saat ingin mengunjungi platform tersebut. Progressive Web Apps (PWA) menjadikan solusi pada permasalahan tersebut. Penelitian ini bertujuan untuk mengimplementasikan PWA pada platform freelance digital. Metode yang digunakan adalah metode Rapid Application Development (RAD) dengan tahapan Requirements Planning, Design Workshop, dan implementation . Hasil penelitian menunjukkan bahwa PWA telah berhasil diimplementasikan pada platform freelance digital. Hal ini dibuktikan dengan hasil pengujian tool dari peramban web, pengujian manual instalasi di layar utama, pengujian responsif, dan pengujian service worker dengan black box. Hasil uji respon pengguna menunjukkan bahwa PWA diterima dengan baik oleh pengguna. Hal ini dibuktikan dengan hasil kuesioner yang menunjukkan bahwa presentase rata-rata kepuasan pengguna adalah 93,5% dengan kategori "Sangat Bagus".
Hubungan Pengetahuan, Sikap, Sarana Prasarana Puskesmas tentang Gizi Seimbang terhadap Perilaku Pemenuhan Gizi Balita
Authors: Anggraeni Putik Silvia , Munawaroh Madinah , Ciptiasrini Uci 
Published: July 2024

Berdasarkan Riset Kesehatan Dasar (RISKESDAS) Tahun 2018, Angka Gizi Buruk dan Stunting masih menjadi permasalahan kesehatan gizi di indonesia, maka hal ini harus segera diatasi agar angka tersebut tidak semakin meningkat. Gizi Merupakan unsur terpenting dalam proses pertumbuhan dan perkembangan balita. Asupan gizi yang baik adalah sesuai dengan pedoman gizi seimbang. Tujuan penelitian untuk mengetahui hubungan pengetahuan, sikap ibu, sarana prasarana puskesmas tentang gizi seimbang terhadap perilaku pemenuhan gizi balita. Jenis penelitiannya adalah penelitian kuantitatif dengan rancangan cross sectional. Penelitian dilakukan bulan Agustus sampai September Tahun 2020, Populasi penelitian adalah ibu yang memiliki balita usia 12-59 Bulan yang ada saat pengambilan sampel, yang dilakukan secara door to door di Wilayah Kelurahan Jatiasih dengan jumlah sampel 219 responden dengan teknik Purposive Sampling. Penelitian ini menggunakan lembar kuesioner. Hasil analisis menunjukkan pengetahuan ibu (P=0,047), Sikap Ibu (P=0,018), dan Sarana Prasarana Puskesmas (P=0,001) bahwa H0 ditolak dikarenakan 3 variabel independen mempunyai nilai p-value < 0.005 yang berarti ada hubungan antara Pengetahuan, Sikap Ibu, dan Sarana Prasarana Puskesmas tentang gizi seimbang terhadap Perilaku pemenuhan gizi balita. Saran bagi Puskesmas diharapkan dapat melakukan advokasi kepada ibu yang memiliki balita mengenai pentingnya pemenuhan gizi seimbang bagi balita sehingga dapat membantu menurunkan angka Stunting dan Gizi Buruk.
Perbandingan Model Pembelajaran ADDIE dan PAIKEM Hasil Belajar Anatomi Fisiologis Kebidanan STIKIM, Indonesia
Authors: Subur Rina Yuliana , Rahayu Sri 
Published: July 2024

Saat ini dalam proses pembelajaran menuntut adanya keanekaragaman atau variasi dalam pembelajaran yang mengarah pada PAIKEM. Penggunaan Model pembelajaran ADDIE menunjukan bahwa aktifitas belajar mengalami peningkatan nilai rata-rata yang cukup baik. Penelitian ini bertujuan untuk mengetahui perbandingan antara penggunaan model pembelajaran ADDIE dan PAIKEM terhadap hasil belajar mata kuliah Anatmoi-Fisiologis mahasiswa kebidanan STIKIM tahun 2014. Penelitian ini menggunakan penelitian Eksperimen dengan Rancangan Eksprerimen semu (Pre Experimental Design) dengan menggunakan rancangan Pretest and Posttest Group. Pengambilan sampel sebanyak 36 responden yang dipecah menjadi 2 kelompok eksperimen yaitu kelompok ADDIE dan kelompok PAIKEM yang akan diberikan Pretest sebelum Treatment kemudian dilakukan Posttest. Analisa data menggunakan uji statistic Non-Parametic yaitu Uji Wilcoxon yang sebelumnya dilakukan pengujian normalitas data menggunakan Uji-Shapiro-Wilk dengan nilai Sig dari Pretest ADDIE adalah 0,033, nilai Sig dari Posttest 0,262. Sedangkan nilai Sig dari Pretest PAIKEM adalah 0,094, nilai Sig dari Posttest PAIKEM 0,885. Hasil Uji-Wilcoxon menunjukan nilai Pretest-Posttest ADDIE (p=0,000), nilai Pretest-Posttest PAIKEM (p=0,000) dari kedua nilai Significancy menunjukan 0,000 (p> 0,005) dengan demikian dapat disimpulkan bahwa ada perbedaan yang signifikan antara hasil belajar Pretest-Posttest dengan model pembelajaran ADDIE dan PAIKEM diperkuat dengan wawancara oleh pihak terkait yang berkompeten yang disarankan mengikuti situasi dan kondisi saat ini.
Penatalaksanaan Pertolongan Pertama Balita Sakit Berbasis MTBS untuk Mencegah Stunting di Desa Cikunir Tasikmalaya
Authors: Apriasih Hapi 
Published: July 2024

Masa balita merupakan masa rentan terhadap berbagai permasalahan kesehatan diantaranya stunting, salah satu penyebabnya adalah riwayat penyakit infeksi serta faktor genetik yang meningkatan kejadian kesakitan dan kematian, dan dapat menyebabkan perkembangan kognitif, motorik, dan verbal pada anak tidak optimal, serta peningkatan biaya kesehatan. Saat ini pengelolaan balita sakit oleh para tenaga kesehatan berbasis Manajemen terpadu balita sakit bertujuan untuk meningkatkan derajat kesehatan anak serta kualitas pelayanan kesehatan anak, dan dimasa pandemic covid 19 ini seharusnya para orangtua mampu melaksanakan penanganan awal balita sakit di rumah. Metode Penelitian adalah Deskriptif, dengan sampel 24 ibu yang mempunyai balita sakit. Hasil penelitian didapatkan penatalaksanaan pertolongan pertama dengan batuk adalah dikompres sebanyak 60%, diberi obat sebanyak 20%, dibalur minyak dan tidak tahu 10%. Pada balita diare adalah 50 % diberi oralit, 25 % diberi balur daun-daunan, bawang minyak. Pada balita dengan demam adalah balur daun-daunan, bawang, minyak dan diberi obat batuk sebanyak 33%, dan dibawa ke dokter 22 %, dan 12 % diberi banyak minum air putih, istirahat yang cukup, kepala diposisikan lebih tinggi dan olesan balsam khusus untuk anak dan penatalaksanaan masalah infeksi telinga adalah langsung dibawa ke dokter spesialis. Dapat disimpulkan pertolongan balita sakit mengkombinasikan antara pengobatan medis dan tradisional.
Design, fabrication, and evaluation of single- and multi-level 3D-printed non-covering cervical spinal fusion surgery templates
Authors: Safahieh A. H. , Nazemi H. , Arjmand N. , Azimi P. , Khalaf K. 
Published: July 2024

BackgroundCervical spinal fusion surgeries require accurate placement of the pedicle screws. Any misplacement/misalignment of these screws may lead to injuries to the spinal cord, arteries and other organs. Template guides have emerged as accurate and cost-effective tools for the safe and rapid insertions of pedicle screws.Questions/PurposesNovel patient-specific single- and multi-level non-covering templates for cervical pedicle screw insertions were designed, 3D-printed, and evaluated.MethodsCT scans of two patients were acquired to reconstruct their 3D spine model. Two sets of single-level (C3-C7) and multi-level (C4-C6) templates were designed and 3D-printed. Pedicle screws were inserted into the 3D-printed vertebrae by free-hand and guided techniques. For single-level templates, a total of 40 screws (2 patients × 5 vertebrae × 2 methods × 2 screws) and for multi-level templates 24 screws (2 patients × 3 vertebrae × 2 methods × 2 screws) were inserted by an experienced surgeon. Postoperative CT images were acquired to measure the errors of the entry point, 3D angle, as well as axial and sagittal plane angles of the inserted screws as compared to the initial pre-surgery designs. Accuracy of free-hand and guided screw insertions, as well as those of the single- and multi-level guides, were also compared using paired t-tests.ResultsDespite the minimal removal of soft tissues, the 3D-printed templates had acceptable stability on the vertebrae during drillings and their utilization led to statistically significant reductions in all error variables. The mean error of entry point decreased from 3.02 mm (free-hand) to 0.29 mm (guided) using the single-level templates and from 5.7 mm to 0.76 mm using the multi-level templates. The percentage reduction in mean of other error variables for, respectively, single- and multi-level templates were as follows: axial plane angle: 72% and 87%, sagittal plane angle: 56% and 78%, and 3D angle: 67% and 83%. The error variables for the multi-level templates generally exceeded those of the single-level templates. The use of single- and multi-level templates also considerably reduced the duration of pedicle screw placements.ConclusionThe novel single- and multi-level non-covering templates are valuable tools for the accurate placement of cervical pedicle screws.
Comprehensive analysis of bioactive compounds in Crocus sativus stamens extracts by HPLC-DAD: investigating antidiabetic activity via in vitro, in vivo, and molecular docking simulation
Authors: Mamri Samira , Daoudi Nour Elhouda , Baraich Abedellah , Ouahhoud Sabir , Khoulati Amine , Choukri Mohammed , Asehraou Abdeslam , Bnouham Mohamed , Jaouadi Bassem , Abousalham Abdelkrim , Dabiellil Fakhreldeen , Salamatullah Ahmad Mohammad , Saalaoui Ennouamane 
Published: July 2024

Introduction: Medicinal herbs used in traditional diabetes treatment are a rich source of anti-diabetic compounds. Pancreatic α-amylase inhibitors offer an effective strategy to reduce postprandial hyperglycemic levels via control of starch degradation. In this context, our study for the first time investigates the effect of Crocus sativus stamens extracts on α-amylase inhibition.Material and methods: The hydromethanolic and hydroethanolic extracts were obtained by macerating the dried stamen powder with methanol/water or ethanol/water, respectively. The total phenolic content of the stamen extracts was assessed using the Folin-Ciocalteu reagent method, while the total flavonoid content was determined using the Aluminum Chloride method. Phytochemicals were further quantified and identified using HPLC-DAD. For evaluation of hypoglycemic activity, in vitro α-amylase enzyme inhibition was calculated. The results were confirmed in vivo using an oral starch tolerance test in both normal and diabetic rats.Results: Our findings demonstrated a higher level of polyphenols and flavonoids in the hydroethanolic extract. Important flavonoids found were kaempferol, rutin, and vanillic acid, while prominent carotenoids contained trans- and cis-crocins. The in vitro study showed that both hydromethanolic and hydroethanolic extracts had considerable inhibitory effects, with maximum inhibitions of approximately 83% and 89%, respectively. In vivo tests indicated that both extracts effectively lowered peak blood glucose and area under the curve in both normal and diabetic rats following oral starch treatment. The obtained results are also supported by a docking study.Conclusion: These findings imply that C. sativus stamens possess a distinctive capability to reduce postprandial blood glucose levels. This effect is likely mediated through the inhibition of α-amylase, presenting a novel dietary avenue for managing diabetes.
Screening for anti-influenza virus compounds from traditional Mongolian medicine by GFP-based reporter virus
Authors: Nie Mao-Shun , Li Xiao-He , Zhang Sen , Zeng Dan-Dan , Cai Yu-Rong , Peng Da-Xin , Jiang Tao , Shi Jian-Ping , Li Jing 
Published: July 2024

IntroductionScreening for effective antiviral compounds from traditional Mongolian medicine not only aids in the research of antiviral mechanisms of traditional medicines, but is also of significant importance for the development of new antiviral drugs targeting influenza A virus. Our study aimed to establish high-throughput, rapid screening methods for antiviral compounds against influenza A virus from abundant resources of Mongolian medicine.MethodsThe use of GFP-based reporter viruses plays a pivotal role in antiviral drugs screening by enabling rapid and precise identification of compounds that inhibit viral replication. Herein, a GFP-based reporter influenza A virus was used to identify potent anti-influenza compounds within traditional Mongolian medicine.ResultsOur study led to the discovery of three active compounds: Cardamonin, Curcumin, and Kaempferide, all of which exhibited significant antiviral properties in vitro. Subsequent analysis confirmed that their effectiveness was largely due to the stimulation of the antiviral signaling pathways of host cells, rather than direct interference with the viral components, such as the viral polymerase.DiscussionThis study showcased the use of GFP-based reporter viruses in high-throughput screening to unearth antiviral agents from traditional Mongolian medicine, which contains rich antiviral compounds and deserves further exploration. Despite certain limitations, fluorescent reporter viruses present substantial potential for antiviral drug screening research due to their high throughput and efficiency.