bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of historical control data for assessing treatment effects in clinical trials
Authors: Viele Kert , Berry Scott , Neuenschwander Beat , Amzal Billy , Chen Fang , Enas Nathan , Hobbs Brian , Ibrahim Joseph G. , Kinnersley Nelson , Lindborg Stacy , Micallef Sandrine , Roychoudhury Satrajit , Thompson Laura 
Published: August 2013

ABSTRACTClinical trials rarely, if ever, occur in a vacuum. Generally, large amounts of clinical data are available prior to the start of a study, particularly on the current study's control arm. There is obvious appeal in using (i.e., ‘borrowing’) this information. With historical data providing information on the control arm, more trial resources can be devoted to the novel treatment while retaining accurate estimates of the current control arm parameters. This can result in more accurate point estimates, increased power, and reduced type I error in clinical trials, provided the historical information is sufficiently similar to the current control data. If this assumption of similarity is not satisfied, however, one can acquire increased mean square error of point estimates due to bias and either reduced power or increased type I error depending on the direction of the bias. In this manuscript, we review several methods for historical borrowing, illustrating how key parameters in each method affect borrowing behavior, and then, we compare these methods on the basis of mean square error, power and type I error. We emphasize two main themes. First, we discuss the idea of ‘dynamic’ (versus ‘static’) borrowing. Second, we emphasize the decision process involved in determining whether or not to include historical borrowing in terms of the perceived likelihood that the current control arm is sufficiently similar to the historical data. Our goal is to provide a clear review of the key issues involved in historical borrowing and provide a comparison of several methods useful for practitioners. Copyright © 2013 John Wiley & Sons, Ltd.
A new turbulence model for offshore wind turbine standards
Authors: Wang H. , Barthelmie R. J. , Pryor S. C. , Kim H. G. 
Published: August 2013

ABSTRACTCorrect turbulence intensity modeling is crucial for fatigue load estimation for wind turbine structural design. It is well known that the International Electrotechnical Commission 61400‐3 Normal Turbulence Model recommended for offshore wind turbine design is not representative of offshore wind conditions. A new model is urgently needed as offshore wind energy is rapidly developing worldwide. After evaluating the suitability of the Normal Turbulence Model at three sites in Asia, Europe and the USA, it is found that wind–wave interaction and stability correction should be taken into account in modeling the offshore turbulence intensity and wind speed relationship. Therefore, a new turbulence intensity model, which models wind–wave interaction with the Charnock equation and adjusts for the influence of atmospheric stability through empirical turbulence scaling functions for the unstable atmospheric boundary layer, was developed. The new model is physically based and is tested against observations from the three sites. It shows better performance than the Normal Turbulence Model and hence is recommended to replace the Normal Turbulence Model. For model application, only two parameters are required, which are defined herein to represent offshore sites with high, medium and low turbulence intensities. Copyright © 2013 John Wiley & Sons, Ltd.
Gradient schemes for two‐phase flow in heterogeneous porous media and Richards equation
Authors: Eymard R. , Guichard C. , Herbin R. , Masson R. 
Published: August 2013

AbstractThe gradient scheme family, which includes the conforming and mixed finite elements as well as the mimetic mixed hybrid family, is used for the approximation of Richards equation and the two‐phase flow problem in heterogeneous porous media. We prove the convergence of the approximate saturation and of the approximate pressures and approximate pressure gradients thanks to monotony and compactness arguments under an assumption of non‐degeneracy of the phase relative permeabilities. Strong convergence results stem from the convergence of the norms of the gradients of pressures, which demand handling the nonlinear time term. Numerical results show the efficiency on these problems of a particular gradient scheme, called the Vertex Approximate Gradient scheme.
Authentication of Edible Vegetable Oil and Refined Recycled Cooking Oil Using a Micro‐UV Spectrophotometer Based on Chemometrics
Authors: Liu Tie‐bing , Zhou Yang , Lv Jin , Chen Zheng‐wei , Li Bo‐bin , Shi Yang 
Published: August 2013

AbstractWe have developed a new method to make a clear distinction between edible oil and refined recycled cooking oil by using a micro‐ultraviolet spectrophotometer and analysis of spectra full data combined with principal component analysis (PCA) and cluster discriminant analysis (CDA). This method shows an excellent capability of distinguishing edible oil from refined recycled cooking oil, which is difficult to accomplish by previous methods using physical and chemical properties. Edible oils and refined recycled cooking oils have the different positions on the resulting plot of PCA and CDA. The oil samples are respectively concentrated relatively distribution and distinct from other kinds, with a certain amount of edge intersection between samples. But the edible oil and refined recycled cooking oil samples have a clear divisional interface. By the increase in sampling and the improvement of modeling, the edge intersection or overlap of commonality between samples can be reduced. Using this method, it is possible to determine qualitatively the identity of unknown samples.
Survey on automatic transcription of music
Authors: Fernandes Tavares Tiago , Garcia Arnal Barbedo Jayme , Attux Romis , Lopes Amauri 
Published: August 2013

Abstract
An automatic music transcriber is a device that detects, without human interference, the musical gestures required to play a particular piece. Many techniques have been proposed to solve the problem of automatic music transcription. This paper presents an overview on the theme, discussing digital signal processing techniques, pattern classification techniques and heuristic assumptions derived from music knowledge that were used to build some of the main systems found in the literature. The paper is focused on the motivations behind each technique, aiming to serve both as an introduction to the theme and as resource for the development of new solutions for automatic transcription.
MEN AND THE 1970s BRITISH WOMEN'S LIBERATION MOVEMENT
Authors: OWEN NICHOLAS 
Published: August 2013

ABSTRACTThis article examines the causes and consequences of the exclusion of men from the British Women's Liberation Movement in the 1970s. In common with many of the new social movements of the period, the Women's Liberation Movement was strongly committed to organizational autonomy and self-reliance, in the belief that the demands of oppressed groups should be formulated and presented directly by the oppressed themselves rather than made on their behalf by others, however sympathetic. Using contemporary archival sources, especially newsletters, conference papers, reports, and correspondence, the article explores the debates that surrounded this commitment, and the differing perspectives offered by socialist, radical, revolutionary, and other feminists. It describes the problems created by the presence of men on the edges of the Women's Liberation Movement in its early years, and the controversies that arose over their removal and the definition of women-only spaces. However, even absent men proved to be divisive, and the ‘problem of men’ persisted throughout the decade. The article also considers the responses of men to their exclusion, and their own self-organization in men's groups.
READING THE RUNES? THE UNITED STATES AND THE MUSLIM BROTHERHOOD AS SEEN THROUGH THE WIKILEAKS CABLES
Authors: FRAMPTON MARTYN , ROSEN EHUD 
Published: August 2013

ABSTRACTThe aftermath of Hosni Mubarak's forced abdication as president of Egypt in 2011 brought the culmination of a long-running debate over whether Western governments should engage with the Muslim Brotherhood. At the heart of that debate was the question of how to judge the Brothers: as ‘moderates’ with whom the US might do business, or as part of a movement ultimately hostile to American interests. As this article demonstrates, the idea of engaging in some form of dialogue with the Brotherhood is itself nothing new to United States diplomats. An examination of the Wikileaks cache of documents confirms that contacts of varying kinds have existed since the first half of the 1980s (with dialogue only abandoned for a brief period during the early years of the ‘war on terror’). Such contacts were a product of the normal, low-level political intelligence-gathering conducted by all American embassies; at no stage were they allowed to jeopardize America's key strategic alliance with the Mubarak regime. Nevertheless, the cables pertaining to the Muslim Brotherhood do reveal the limits of such diplomacy, with officials often struggling either to understand the character of the Brotherhood, or read the runes of its internal contours. In particular, the question of whether the Muslim Brothers should indeed be seen as ‘moderates ‘– and as suitable partners for the US – is shown to be one of enduring, but unresolved, concern. The history of this relationship thus serves as a crucial backdrop to contemporary debates and developments.
The Tertiary relict tree Zelkova abelicea (Ulmaceae): distribution, population structure and conservation status on Crete
Authors: Kozlowski Gregor , Frey David , Fazan Laurence , Egli Bernhard , Bétrisey Sébastien , Gratzfeld Joachim , Garfì Giuseppe , Pirintsos Stergios 
Published: August 2013

AbstractRelict species provide a unique opportunity to understand past and recent biogeographical and evolutionary processes. Zelkova abelicea (Ulmaceae), which is endemic to the island of Crete (Greece), is one of the most prominent Tertiary relict trees of the Mediterranean region. We collected distribution, threat and population structure data by reviewing literature and herbaria and through field surveys at 14 study plots throughout the range of the species. The present distribution of Z. abelicea is extremely fragmented. Although the total estimated number of individuals is relatively high, the populations are dominated by dwarf, severely browsed, non-flowering individuals. The population structure is asymmetric. At most, 5% of a plot's trees are large and fruit-bearing. The asymmetric structure is particularly pronounced in isolated and small populations. Based on its limited geographical range, the fragmented spatial pattern, and data on distribution and population structure, our study confirms that Z. abelicea is a threatened species (IUCN category Endangered). Our research aim is to promote the development of new approaches for the improvement of conservation strategies for Tertiary relict trees characterized by major local disjunctions.
An RNA folding motif: GNRA tetraloop–receptor interactions
Authors: Fiore Julie L. , Nesbitt David J. 
Published: August 2013

AbstractNearly two decades after Westhof and Michel first proposed that RNA tetraloops may interact with distal helices, tetraloop–receptor interactions have been recognized as ubiquitous elements of RNA tertiary structure. The unique architecture of GNRA tetraloops (N=any nucleotide, R=purine) enables interaction with a variety of receptors, e.g., helical minor grooves and asymmetric internal loops. The most common example of the latter is the GAAA tetraloop–11 nt tetraloop receptor motif. Biophysical characterization of this motif provided evidence for the modularity of RNA structure, with applications spanning improved crystallization methods to RNA tectonics. In this review, we identify and compare types of GNRA tetraloop–receptor interactions. Then we explore the abundance of structural, kinetic, and thermodynamic information on the frequently occurring and most widely studied GAAA tetraloop–11 nt receptor motif. Studies of this interaction have revealed powerful paradigms for structural assembly of RNA, as well as providing new insights into the roles of cations, transition states and protein chaperones in RNA folding pathways. However, further research will clearly be necessary to characterize other tetraloop–receptor and long-range tertiary binding interactions in detail – an important milestone in the quantitative prediction of free energy landscapes for RNA folding.
Outbreak ofSalmonella entericaserotype I 4,5,12:i:- infections: the challenges of hypothesis generation and microwave cooking
Authors: MODY R. K. , MEYER S. , TREES E. , WHITE P. L. , NGUYEN T. , SOWADSKY R. , HENAO O. L. , LAFON P. C. , AUSTIN J. , AZZAM I. , GRIFFIN P. M. , TAUXE R. V. , SMITH K. , WILLIAMS I. T. 
Published: August 2013

SUMMARYWe investigated an outbreak of 396Salmonella entericaserotype I 4,5,12:i:- infections to determine the source. After 7 weeks of extensive hypothesis-generation interviews, no refined hypothesis was formed. Nevertheless, a case-control study was initiated. Subsequently, an iterative hypothesis-generation approach used by a single interviewing team identified brand A not-ready-to-eat frozen pot pies as a likely vehicle. The case-control study, modified to assess this new hypothesis, along with product testing indicated that the turkey variety of pot pies was responsible. Review of product labels identified inconsistent language regarding preparation, and the cooking instructions included undefined microwave wattage categories. Surveys found that most patients did not follow the product's cooking instructions and did not know their oven's wattage. The manufacturer voluntarily recalled pot pies and improved the product's cooking instructions. This investigation highlights the value of careful hypothesis-generation and the risks posed by frozen not-ready-to-eat microwavable foods.
Influence of electron injection into 27 cm audio plasma cell on the plasma diagnostics
Authors: Haleem N. A. , El Fiki S. A. , Nouh S. A. , El Disoki T. M. , Ragheb M. S. , Zakhary S. G. 
Published: August 2013

In this article, the plasma is created in a Pyrex tube (L = 27 cm, ϕ = 4 cm) as a single cell, by a capacitive audio frequency (AF) discharge (f = 10–100 kHz), at a definite pressure of ∼0.2 Torr. A couple of tube linear and deviating arrangements show plasma characteristic conformity. The applied AF plasma and the injection of electrons into two gas mediums Ar and N2 revealed the increase of electron density at distinct tube regions by one order to attain 1013/cm3. The electrons temperature and density strengths are in contrast to each other. While their distributions differ along the plasma tube length, they show a decaying sinusoidal shape where their peaks position varies by the gas type. The electrons injection moderates electron temperature and expands their density. The later highest peak holds for the N2 gas, at electrons injection it changes to hold for the Ar. The sinusoidal decaying density behavior generates electric fields depending on the gas used and independent of tube geometry. The effect of the injected electrons performs a responsive impact on electrons density not attributed to the gas discharge. Analytical tools investigate the interaction of the plasma, the discharge current, and the gas used on the electrodes. It points to the emigration of atoms from each one but for greater majority they behave to a preferred direction. Meanwhile, only in the linear regime, small percentage of atoms still moves in reverse direction. Traces of gas atoms revealed on both electrodes due to sheath regions denote lack of their participation in the discharge current. In addition, atoms travel from one electrode to the other by overcoming the sheaths regions occurring transportation of particles agglomeration from one electrode to the other. The electrons injection has contributed to increase the plasma electron density peaks. These electrons populations have raised the generated electrostatic fields assisting the elemental ions emigration to a preferred electrode direction. Regardless of plasma electrodes positions and plasma shape, ions can be departed from one electrode to deposit on the other one. In consequence, as an application the AF plasma type can enhance the metal deposition from one electrode to the other.
A Strain of Siniperca chuatsi Rhabdovirus Causes High Mortality among Cultured Largemouth Bass in South China
Authors: Ma Dongmei , Deng Guocheng , Bai Junjie , Li Shengjie , Yu Lingyun , Quan Yingchun , Yang Xiaojing , Jiang Xiaoyan , Zhu Zemin , Ye Xing 
Published: August 2013

Abstract
In April 2011, 40% mortality of Largemouth Bass Micropterus salmoides juveniles occurred at a farm of Zhongshan City, Guangdong Province, China. Infected fish became lethargic, exhibited corkscrew and irregular swimming, and developed a distended abdomen and crooked body. Fish began to die within 2 d after the appearance of clinical signs. In order to analyze the pathogeny and diagnose the disease earlier, observation of clinical signs, cell infection, titer calculation, electron microscopy, immersion infection assay for fish, and nucleotide sequence analysis were carried out. Fathead minnow (FHM) cell cultures, inoculated with filtrate of liver and spleen homogenates from the diseased fish, developed the obvious cytopathic effect 46 h after inoculation in the primary culture and 24 h at the first passage. Typical rhabdovirus particles, 115–143 nm in length and 62–78 nm in diameter, were observed in infected FHM cells by direct transmission electron microscopy. The isolated virus produced a titer of 107.15 TCID50/mL. Immersion-Fish infected with the virus had similar clinical signs and 80% mortality with 102.5 LD50/mL. The data indicated that the rhabdovirus was the lethal pathogeny of the current disease. Based on nucleoprotein-gene nucleotide sequence multiple alignment analysis, the newly isolated virus is a strain of Siniperca chuatsi rhabdovirus (SCRV) under family Rhabdoviridae, which was initially isolated from Mandarin Fish Siniperca chuatsi. Up to the present, at least four virus strains have been isolated from diseased Largemouth Bass, which have had different clinical signs. Comparison of the clinical signs can help in an early diagnosis of the disease.
Received October 30, 2012; accepted April 19, 2013
The ecology of seed dispersal by small rodents: a role for predator and conspecific scents
Authors: Sunyer Pau , Muñoz Alberto , Bonal Raúl , Espelta Josep M. 
Published: August 2013

Summary

Seed‐caching rodents play a key role in the ecology of seed dispersal by not only consuming but also dispersing seeds. Rodent foraging behaviour is usually framed within optimal models, which predict that their decisions should maximize food intake and minimize foraging costs. Although predation risk and seed pilferage by conspecifics have been envisaged as two potential costs, their relevance for seed‐caching behaviour and seed dispersal has barely been addressed.

To test the effect of predation and pilferage risk on the patterns of seed predation/dispersal by rodents, we performed a field experiment using a tri‐trophic‐level model (plant–mice–carnivore; Quercus spp‐Apodemus sylvaticus‐Genetta genetta) and the scents of the predator and conspecifics as direct cues. The behaviour of mice was analysed with video cameras set for continuous recording on consecutive nights, and we used tagged acorns to assess the patterns of acorn predation and dispersal.

Our results revealed that rodents were able to discriminate between the scents of genet and conspecifics and modified their seed dispersal behaviour accordingly. Mice spent more time ‘sniffing’ in rodent cages than in genet cages, where they displayed more ‘vigilance and freezing’ behaviours. In sites with mice scents, acorns were dispersed at shorter distances and were less predated. Conversely, in sites with genet scents acorn removal was delayed.

These results show that chemosensory information on predators and conspecifics influences the foraging decisions of seed‐caching rodents over short spatial and temporal scales. This might entail cascading effects on the regeneration of plants. In sites where rodents perceive the risk of predation, inefficient foraging behaviour may result in less successful seed dispersal. Conversely, the detection of conspecific scents may increase dispersal efficiency and seedling recruitment.

Ultimately, the relationships between two distant levels in trophic webs (plants–carnivores) appear intricate, since carnivores may affect seed dispersal by changing the foraging behaviour of their prey (the seed disperser). This indirect relationship should be considered as a new dimension of the ecology of seed dispersal by small rodents.
Convergent effects of elevation on functional leaf traits within and among species
Authors: Read Quentin D. , Moorhead Leigh C. , Swenson Nathan G. , Bailey Joseph K. , Sanders Nathan J. 
Published: August 2013

Summary

Spatial variation in filters imposed by the abiotic environment causes variation in functional traits within and among plant species. This is abundantly clear for plant species along elevational gradients, where parallel abiotic selection pressures give rise to predictable variation in leaf phenotypes among ecosystems. Understanding the factors responsible for such patterns may provide insight into the current and future drivers of biodiversity, local community structure and ecosystem function.

In order to explore patterns in trait variation along elevational gradients, we conducted a meta‐analysis of published observational studies that measured three key leaf functional traits that are associated with axes of variation in both resource competition and stress tolerance: leaf mass:area ratio (LMA), leaf nitrogen content per unit mass (Nmass) and N content per unit area (Narea). To examine whether there may be evidence for a genetic basis underlying the trait variation, we conducted a review of published results from common garden experiments that measured the same leaf traits.

Within studies, LMA and Narea tended to decrease with mean annual temperature (MAT) along elevational gradients, while Nmass did not vary systematically with MAT. Correlations among pairs of traits varied significantly with MAT: LMA was most strongly correlated with Nmass and Narea at high‐elevation sites with relatively lower MAT. The strengths of the relationships were equal or greater within species relative to the relationships among species, suggesting parallel evolutionary dynamics along elevational gradients among disparate biomes. Evidence from common garden studies further suggests that there is an underlying genetic basis to the functional trait variation that we documented along elevational gradients.

Taken together, these results indicate that environmental filtering both selects locally adapted genotypes within plant species and constrains species to elevational ranges based on their ranges of potential leaf trait values. If individual phenotypes are filtered from populations in the same way that species are filtered from regional species pools, changing climate may affect both the species and functional trait composition of plant communities.