bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mineral Reconnaissance Through Scientific Consensus: First National Prospectivity Maps for PGE–Ni–Cu–Cr and Witwatersrand-type Au Deposits in South Africa
Authors: Nwaila Glen T. , Zhang Steven E. , Bourdeau Julie E. , Carranza Emmanuel John M. , Enslin Stephanie , Manzi Musa S. D. , Andriampenomanana Fenitra , Ghorbani Yousef 
Published: August 2024

AbstractWe present here the first experimental science (consensus)-based mineral prospectivity mapping (MPM) method and its validation results in the form of national prospectivity maps and datasets for PGE–Ni–Cu–Cr and Witwatersrand-type Au deposits in South Africa. The research objectives were: (1) to develop the method toward applicative uses; (2) to the extent possible, validate the effectiveness of the method; and (3) to provide national MPM products. The MPM method was validated by targeting mega-deposits within the world’s largest and best exploited geological systems and mining districts—the Bushveld Complex and the Witwatersrand Basin. Their incomparable knowledge and mega-deposit status make them the most useful for validating MPM methods, serving as “certified reference targets”. Our MPM method is built using scientific consensus via deep ensemble construction, using workflow experimentation that propagates uncertainty of subjective workflow choices by mimicking the outcome of an ensemble of data scientists. The consensus models are a data-driven equivalent to expert aggregation, increasing confidence in our MPM products. By capturing workflow-induced uncertainty, the study produced MPM products that not only highlight potential exploration targets but also offer a spatial consensus level for each, de-risking downstream exploration. Our MPM results agree qualitatively with exploration and geological knowledge. In particular, our method identified areas of high prospectivity in known exploration regions and geologically and geospatially corresponding to the known extents of both mineral systems. The convergence rate of the ensemble demonstrated a high level of statistical durability of our MPM products, suggesting that they can guide exploration at a national scale until significant new data emerge. Potential new exploration targets for PGE–Ni–Cu–Cr are located northwest of the Bushveld Complex; for Au, promising areas are west of the Witwatersrand Basin. The broader implications of this work for the mineral industry are profound. As exploration becomes more data-driven, the question of trust in MPM products must be addressed; it can be done using the proposed scientific method.
Graphical Abstract
Impact of geohazards on cadastral data: an assessment after the 6 February 2023 Kahramanmaras earthquakes (Türkiye)
Authors: Yildiz Umit , Gokceoglu Candan , Kocaman Sultan 
Published: August 2024

Abstract
Humans set boundaries on land for thousands of years. Cadastre emerged as a system for registering them, whether they are marked on the ground (visible) or unmarked (invisible). Parcel boundary data stored in geospatial databases and supported with registration documents are legally binding in many countries. They are however subject to change physically due to anthropogenic activities and natural processes. Seismic activities inducing surface rupture, lateral spread, landslide, liquefaction, and rockfall are among the main natural causes yielding physical boundary alterations. Spatial pattern and magnitude of alterations depend on the geohazard type and geological characteristics of the area. If a cadastral database is not updated, the physical and registered boundary begins to diverge, leading to uncertainty that needs to be understood by both people and authorities. As a prominent example, the 6 February 2023 Kahramanmaras (Turkiye) earthquakes (Mw7.7 and Mw7.6), which affected a very large region covering approximately 100,000 km2, caused enormous alterations on the physical boundaries of approximately 5 million land parcels. In this study, we analyzed different boundary changes caused by this major event and proposed a conceptual framework based on physical, documentary, and spatial boundary definitions of cadastral parcels with examples from the Kahramanmaras earthquakes. Considering the size of the area and the immense cost of cadastral renovation projects, we analyzed the deformation patterns and possible magnitudes from an interdisciplinary perspective and presented an overview. The study findings provide insights for addressing boundary discrepancies, although additional research is required for comprehensive quantitative assessments across the entire area.
Stepwise Multi-Temperature Thermogravimetric Analysis (SMT-TGA) for Rapid Alloy Development
Authors: Monceau Daniel , Enjalbert Hugo , Desgranges Clara , Sanviemvongsak Tom , Casadebaigt Antoine , Perez Thomas 
Published: August 2024

AbstractA stepwise multi-temperature thermogravimetric analysis (SMT-TGA) method is a rapid and time- and material-efficient measurement procedure for oxidation kinetics over a wide range of temperatures. It is suitable for alloy design and material selection procedures. It involves subjecting a sample to a series of steps at increasing temperatures, followed by steps at decreasing temperatures to identify possible effects on the evolution of oxide layer microstructures on oxidation kinetics. This method has been tested for a wide range of metallic alloys in the present work, allowing for the mapping of possible ranges of parabolic oxidation kinetics of industrial alloys between 600 and 1300°C. Two examples of effects of thermal history have also been described in this publication.
Integrated analyses of the plant and soil microbiome identify Phytopythium vexans as agent of the Kiwifruit Vine Decline Syndrome
Authors: Mosca Saveria , Aci Meriem Miyassa , Procopio Giuseppina , Vadalà Vittoria , Vizzari Giuseppina , Francomano Edda , Mohamed Nesma Zakaria , Li Destri Nicosia Maria Giulia , Agosteo Giovanni Enrico , Spadaro Davide , Schena Leonardo , Malacrinò Antonino 
Published: August 2024

Abstract
Background and aims
The Kiwifruit Vine Decline Syndrome (KVDS) is a disease that is currently a challenge for kiwifruit production in Italy, and it is spreading in new production areas. However, the causal agent of this syndrome has not been clearly identified, and we still know little about the overall effects of KVDS on the interactions between the host plant and its microbiome.

Methods
In this study, we combined metabarcoding and targeted isolation (leaf baiting) to characterize the changes in the rhizosphere and root microbiomes associated with symptoms of KVDS.

Results
Our results suggest that KVDS has little impact on the bacterial, fungal, and oomycete communities associated with soil and roots, and we detected weak signatures of potential dysbiosis. On the other hand, we found a consistent association of the oomycete Phytopythium vexans with samples from plants symptomatic to KVDS, which matches the nucleotide sequences of the isolates obtained through baiting and, partially, the isolates from previous studies.

Conclusion
While our results support the idea that P. vexans might be the major candidate agent of KVDS, there are still several unanswered questions that need to be addressed before being able to provide effective solutions to this emerging challenge in kiwifruit production.
Comparing patient-reported outcomes measurement information system® (PROMIS®)-16 domain scores with the PROMIS-29 and 5-item PROMIS cognitive function scores
Authors: Zeng Chengbo , Hays Ron D. , Rodriguez Anthony , Hanmer Janel , Herman Patricia M. , Edelen Maria Orlando 
Published: August 2024

Abstract

Purpose
This study evaluates the interpretability of Patient-Reported Outcomes Measurement Information System® (PROMIS®)-16 profile domain scores (physical function, ability to participate in social roles and activities, anxiety, depression, sleep disturbance, pain interference, cognitive function – abilities, and fatigue) compared to the PROMIS-29 scores and a 5-item PROMIS cognitive function score. The study aims to provide insights into using these measures in clinical and research settings.

Methods
Analyses were conducted using data from 4130 adults from a nationally representative, probability-based internet panel between September and October 2022. A subset of 1256 individuals with back pain was followed up at six months. We compared the PROMIS-16 profile with the corresponding domain scores from the PROMIS-29 and a custom five-item cognitive function measure. We evaluated (1) reliability through inter-item correlations within each domain and (2) criterion validity by comparing PROMIS-16 profile with the corresponding longer PROMIS measures: (a) standardized mean differences in domain scores, (b) correlations, and (c) concordance of change (i.e., got worse, stayed the same, got better) among those with back pain from baseline to six months later using the reliable change index. We report the Kappa coefficient of agreement and the frequency and percentage of participants with concordant classifications.

Results
Inter-item correlations for the PROMIS-16 domains ranged from 0.65 in cognitive function to 0.92 in pain interference. Standardized mean differences between PROMIS-16 and the scores for the corresponding longer PROMIS domains were minimal (< 0.2). Correlations among the corresponding domain scores ranged from 0.82 for sleep disturbance to 0.98 for pain interference. The percentage of concordance in change groups ranged from 63% for sleep disturbance to 88% for pain interference. Except for sleep disturbance, the change groups derived from the PROMIS-16 showed moderate to substantial agreement with scores estimated from the longer PROMIS measures (Kappa coefficients ≥ 0.41).

Conclusion
The PROMIS-16 domain scores perform similarly to the longer PROMIS measures and can be interpreted in the same way. This similarity indicates that PROMIS-16 can be useful for research as a brief health-related quality-of-life profile measure.
The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
Authors: Roesner Lennart Matthias , Gupta Manoj Kumar , Kopfnagel Verena , van Unen Nienke , Kemmling Yvonne , Heise Jana-Kristin , Castell Stephanie , Jiang Xun , Riemann Lennart , Traidl Stephan , Lange Berit , Sühs Kurt-Wolfram , Illig Thomas , Strowig Till , Li Yang , Förster Reinhold , Huehn Jochen , Schulz Thomas Friedrich , Werfel Thomas ,   the RESIST SI Cohort Investigators, Bošnjak Berislav , Gutierrez Jauregui Rodrigo , Jenniches Felix , Klopp Norman , Lesker Till Robin , Stangel Martin 
Published: August 2024

AbstractThe number of older adults worldwide is growing exponentially. However, while living longer, older individuals are more susceptible to both non-infectious and infectious diseases, at least in part due to alterations of the immune system. Here, we report on a prospective cohort study investigating the influence of age on immune responses and susceptibility to infection. The RESIST Senior Individuals (SI) cohort was established as a general population cohort with a focus on the elderly, enrolling an age- and sex-stratified sample of 650 individuals (n = 100 20-39y, n = 550 61-94y, 2019–2023, Hannover, Germany). It includes clinical, demographic, and lifestyle data and also extensive biomaterial sampling. Initial insights indicate that the SI cohort exhibits characteristics of the aging immune system and the associated susceptibility to infection, thereby providing a suitable platform for the decoding of age-related alterations of the immune system and unraveling the molecular mechanisms underlying the impaired immune responsiveness in aging populations by exploring comprehensive, unbiased multi-omics datasets.
Nutrient Status and Supplement Use During Pregnancy Following Metabolic Bariatric Surgery: A Multicenter Observational Cohort Study
Authors: Heusschen Laura , Berendsen Agnes A. M. , van Bon Arianne C. , van Laar Judith O. E. H. , Krabbendam Ineke , Hazebroek Eric J. 
Published: August 2024

Abstract
Introduction
Pregnant women with a history of metabolic bariatric surgery (MBS) are at high risk of developing nutrient deficiencies, leading to greater challenges to reach nutritional requirements. This study compared nutrient status of women using specialized “weight loss surgery” multivitamin supplementation (WLS-MVS) to those using standard supplementation (sMVS) during pregnancy following MBS.

Methods
Multicenter observational cohort study including 119 pregnant women at 41.0 (18.5–70.0) months after Roux-en-Y gastric bypass (RYGB, n = 80) or sleeve gastrectomy (SG, n = 39). Routine blood samples were analyzed every trimester (T1, T2, T3), and micronutrient serum levels were compared between WLS-MVS and sMVS users.

Results
During pregnancy after RYGB, WLS-MVS users demonstrated higher serum concentrations of hemoglobin (7.4 [7.2, 7.5] vs. 7.0 [6.8, 7.3] mmol/L), ferritin (23.2 [15.0, 35.7] vs. 13.7 [8.4, 22.4] µg/L), and folic acid (31.4 [28.7, 34.2] vs. 25.4 [21.3, 29.4] nmol/L) and lower serum vitamin B6 levels (T1: 90.6 [82.0, 99.8] vs. 132.1 [114.6, 152.4] nmol/L) compared to sMVS users. Iron deficiencies and elevated serum vitamin B6 levels were less prevalent in the WLS-MVS group. During pregnancy after SG, WLS-MVS users showed higher serum vitamin D concentrations (89.7 [77.6, 101.8] vs. 65.4 [53.3, 77.4] nmol/L) and lower serum vitamin B1 concentrations (T2: 137.4 [124.2, 150.6] vs. 161.6 [149.0, 174.1] nmol/L, T3: 133.9 [120.1, 147.7] vs. 154.7 [141.9, 167.5] nmol/L) compared to sMVS users.

Conclusion
Low maternal concentrations of micronutrients are highly prevalent during pregnancy after MBS. The use of specialized multivitamin supplementation generally resulted in higher serum levels during pregnancy compared to standard supplementation. Future research is needed to investigate how supplementation strategies can be optimized for this high-risk population.

Graphical Abstract
Implementation of fracture risk assessment in men with prostate cancer requiring long-term androgen deprivation therapy: a systematic scoping review using the i-PARIHS implementation framework
Authors: Huang Qizhi , Mitchell Caroline , Theodoulou Elisavet , Lee Andrew C. K. , Brown Janet 
Published: August 2024

Abstract
Purpose
Androgen deprivation therapy (ADT) is a mainstay of treatment for prostate cancer (PCa) and is associated with increased risks of osteoporosis and fragility fractures. Despite international guidelines to mitigate fracture risk, osteoporosis is under-diagnosed and under-treated due to poor implementation. This scoping review aims to synthesise knowledge surrounding the implementation of guidelines to inform health service interventions to reduce fracture risk in men with PCa-taking ADT (PCa-ADT).

Method
Four databases and additional literature were searched for studies published between January 2000 and January 2023. Studies that provided evidence influencing guidelines implementation were included. The i-PARIHS (Promoting Action on Research Implementation in Health Services) implementation framework was used to inform the narrative synthesis.

Results
Of the 1229 studies identified, 9 studies met the inclusion criteria. Overall, an improvement in fracture risk assessment was observed across heterogeneous study designs and outcome measures. Six studies were from Canada. Two studies involved family physicians or a community healthcare programme. Two studies incorporated patient or specialist surveys. One utilised an implementation framework. Implementation barriers included the lack of knowledge for both patients and clinicians, time constraints, unsupportive organisational structures, and challenges in transferring patient care from specialists to primary care. Effective strategies included education, novel care pathways using a multidisciplinary approach, incorporating a healthy bone prescription tool into routine care, point-of-care interventions, and bespoke clinics.

Conclusion
There is an unmet need to provide evidence-based bone healthcare in men with PCa receiving ADT. This study highlights barriers and strategies in the implementation of fracture risk assessment for PCa-ADT patients.

Implications for Cancer Survivors
Primary care clinicians can play a significant role in the management of complications from long-term cancer treatment such as treatment-induced bone loss. Future studies should consult patients, families, specialists, and primary care clinicians in service re-design.
Association between JAK2V617F variable allele frequency and risk of thrombotic events in patients with myeloproliferative neoplasms
Authors: Brown Ryan , Jasiakiewicz Joanna , Greer Victoria , Hindley Andrew , McDowell Katie , Devlin Eadaoin , Clarke Kathryn , Buckley Frances , Crean Clare , McGimpsey Julie , Cuthbert Robert J. G. , Cunningham Nick , Arnold Claire , Finnegan Damian , Benson Gary , McMullin Mary Frances , Catherwood Mark A. 
Published: August 2024

Abstract
Background
Myeloproliferative neoplasms (MPNs) are a group of chronic disorders of the bone marrow characterised by the overproduction of clonal myeloid stem cells. The most common driver mutation found in MPNs is a point mutation on exon 14 of the JAK2 gene, JAK2V617F. Various studies have suggested that measuring the variable allele frequency (VAF) of JAK2V617F may provide useful insight regarding diagnosis, treatment, risks and outcomes in MPN patients. In particular, JAK2V617F has been associated with increased risk of thrombotic events, a leading cause of mortality in MPNs.

Aims
The aim of this study was to determine if JAK2V617F VAF was associated with clinical outcomes in patients with MPN.

Methods
JAK2V617F VAF was determined by quantitative PCR (qPCR) in a cohort of 159 newly diagnosed MPN patients, and the association of JAK2V617F VAF and risk of thrombosis was examined in this cohort.

Results
We observed a significantly higher JAK2V617F VAF in PV and PMF versus ET. A significant association was observed between JAK2V617F VAF and risk of thrombotic events. When patients were stratified by thrombotic events prior to and post diagnosis, an association with JAK2V617F VAF was only observed with post diagnosis thrombotic events. Of note, these associations were not observed when looking at each MPN subtype in isolation.

Conclusions
We have shown that a higher JAK2V617F VAF is associated with thrombotic events post MPN diagnosis. JAK2V617F VAF may therefore provide a valuable prognostic indicator for risk of thrombosis in MPNs.
Application of Steady-State and Time-Resolved Fluorescence Spectroscopy in Identification of Bee Products
Authors: Szukay Beata , Gałęcki Krystian , Kowalska-Baron Agnieszka , Budzyński Jacek , Fisz Jacek J. 
Published: August 2024

AbstractIn this study, steady-state and time-resolved fluorescence spectroscopy techniques have been applied to determine fluorescence characteristics and fluorescence decay kinetics parameters (fluorescence lifetimes and their amplitudes) of available on the Polish market bee products, including several nectar honeys, royal jelly, bee bread in honey and in liquid artificial honey. The fluorescence properties of the tested bee products arise from the presence of a unique composition of aromatic amino acids, vitamins, phenolic compounds and Maillard reaction products. In the 300–550 nm region of the emission spectra (excited at 280 nm), each of the tested bee products exhibited (showed) a specific and distinctive vibronic structure, which was not observed in the spectrum of artificial honey. Quantitative and qualitative composition as well as specific interactions between fluorescent constituents determine the specific fluorescence characteristics of a given bee product providing a unique fingerprint that can be used in the identification of bee products of different botanical origin. Combination of stationary and time-resolved fluorescence techniques seems to be a promising approach in the identification, authentication and quality control of bee products to verify their health-beneficial properties.
Which heart failure patients benefit most from non-invasive telemedicine? An overview of current evidence and future directions
Authors: van Eijk Jorna , Luijken Kim , Trappenburg Jaap , Jaarsma Tiny , Asselbergs Folkert W. 
Published: August 2024

AbstractTelemedicine in heart failure (HF) management may positively impact health outcomes, but varied effects in studies hinder guidance in HF guidelines. Evidence on the effectiveness of telemedicine in HF subpopulations is limited. We conducted a scoping review to evaluate and synthesise evidence on the effectiveness of telemedicine across HF subpopulations that could guide telemedicine strategies in routine practice. Meta-analyses concerning randomised controlled trials (RCTs) with subgroup analyses on telemedicine effectives were identified in PubMed. We identified 15 RCTs, encompassing 21 different subgroups based on characteristics of HF patients. Findings varied across studies and no definite evidence was found about which patients benefit most from telemedicine. Subgroup definitions were inconsistent, not always a priori defined and subgroups contained few patients. Some studies found heterogeneous effects of telemedicine on mortality and hospitalisation across subgroups defined by: New York Heart Association (NYHA) classification, previous HF decompensation, implantable device, concurrent depression, time since hospital discharge and duration of HF. Patients represented in the RCTs were mostly male, aged 65–75 years, with HF with reduced ejection fraction and NYHA class II/III. Traditional RCTs have not been able to provide clinicians with guidance; continuous real-world evidence generation could enhance monitoring and identify who benefits from telemedicine.