bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences reporting on mental illness and suicide: Findings from interviews with Australian news professionals
Authors: Ross Anna M , Dickson Kara , Morgan Amy J , Paton Elizabeth , McNaught Gayle , Reavley Nicola J 
Published: August 2024

Improvements in the quality of news portrayals of mental illness and suicide can be attributed to the introduction of media guidelines, particularly the Mindframe guidelines in Australia. However, based on reports about problematic media content, there remains scope for improvement. This study sought to further investigate the experiences of Australian news media professionals in reporting on mental illness and suicide, including their experiences of using the Mindframe guidelines and developing news stories about people with lived experience. We conducted semi-structured interviews with 12 media professionals, including junior reporters, senior reporters, and news editors. Media professionals had an average of 10.1 years’ (SD = 9.4) experience and represented a range of work experiences. Three key themes were generated from participant responses about their experiences reporting on mental illness and suicide: 1. Awareness of responsible reporting guidelines and how to proactively increase this; 2. Newsroom processes, values and subjectivity in applying guidelines; and 3. The importance and challenge in sharing lived experience stories, and improving support for covering these stories. Further resources and education are needed across newsrooms and universities to increase awareness and use of the Mindframe guidelines, and ultimately improve the quality of Australian media portrayals of mental illness and suicide. Editors and managers should be targeted with this training to best influence organisational change. Media professionals require additional preparation and support to develop lived experience stories, particularly in working with people bereaved by suicide to ensure this is a safe engagement for both parties.
Basilar artery occlusion management: An international survey of gender influence on management
Authors: Peacock Meabh , Drumm Brian , Klein Piers , Raymond Jean , Huo Xiaochuan , Chen Yimin , Abdalkader Mohamad , Schonewille Wouter J. , Liu Xinfeng , Hu Wei , Li Chuanhui , Ji Xunming , Alemseged Fana , Liu Liping , Siegler James E. , Nagel Simon , Strbian Daniel , Sacco Simona , Yaghi Shadi , Qureshi Muhammad M. , Fischer Urs , Aguiar de Sousa Diana , Yamagami Hiroshi , Michel Patrik , Puetz Volker , Mujanovic Adnan , Marto João Pedro , Kristoffersen Espen Saxhaug , Sandset Else C. , Demeestere Jelle , Hanning Uta , Novakovic Robin , Kenmuir Cynthia , Agid Ronit , Romoli Michele , Diana Francesco , Lobotesis Kyriakos , Roi Dylan , Masoud Hesham E. , Ma Alice , Zhu Yuyou , Sang Hongfei , Sun Dapeng , Ton Mai Duy , Raynald  , Li Fengli , Nasreldein Ahmed , Jesser Jessica , Kaesmacher Johannes , Weyland Charlotte S. , Meyer Lukas , Yeo Leonard L.L. , Yang Qingwu , Thomalla Götz , Yang Pengfei , Poli Sven , Campbell Bruce C.V. , Qureshi Adnan I. , Chen Hui-Sheng , Zaidat Osama O. , Qiu Zhongming , Nogueira Raul G. , Jovin Tudor G. , Miao Zhongrong , Nguyen Thanh N. , Banerjee Soma 
Published: August 2024

Background The superiority of endovascular thrombectomy (EVT) over medical management was not established in two early basilar artery occlusion (BAO) randomized controlled trials. Despite this, many clinicians recommended EVT for acute BAO under certain circumstances. This paper aims to compare physicians’ diagnostic and management strategies of BAO according to gender. Methods From January to March 2022 an international survey was conducted regarding management strategies in acute BAO. We compared responses between clinicians by identifying gender. Questions were designed to examine clinical and imaging parameters influencing management of patients with BAO. Results Among the 1245 respondents from 73 countries, 311 (25.0%) identified as female. This figure was 13.6% amongst interventionists. Geographically, female respondents were lowest in Asia (14.5%) and North America (23.9%). The proportion of respondents identifying as female was consistent regardless of their years of experience. Female respondents were more likely to choose time of onset as time of first estimated stroke like symptom (48.0% vs. 38.5%, p < .01), were less likely to favor thrombectomy in the V4 segment of vertebrobasilar artery occlusions (31.5% vs. 43.3%, p < .01), and were less likely to find it acceptable to enroll all patients who met trial criteria in the standard medical treatment arm of a clinical trial (41.2% vs. 47.0%, p = .01). Male respondents were more likely to agree that thrombolysis would not alter their decision on proceeding with EVT (93.7% vs. 88.3%, p < .01). Conclusions Female clinicians appear to be significantly underrepresented in stroke medicine. This is most pronounced amongst interventionists and in Asia. Although male and female opinions were closely aligned on many aspects of BAO management, differences in opinion were observed in a number of significant areas which influence decision making.
Differential miR-195-5p and its potential role during the development of carotid artery stenosis
Authors: Gao Haining , Zhao Liansheng , Cao Xuemei , Zhang Guoxin 
Published: August 2024

Objectives Carotid artery stenosis (CAS) is a leading cause of cerebral ischemic events (CIE). Timely detection and risk assessment can aid in managing CAS patients and improving their prognosis. The aim of the current study is to identify a new biomarker for CAS and to further investigate the impact of miR-195-5p on cellular processes in vascular smooth muscle cells (VSMCs). Methods This study involved 112 CAS patients and 65 healthy individuals. Serum miR-195-5p levels were measured using RT-qPCR. The ROC curve was then plotted to evaluate the diagnostic potential of miR-195-5p for CAS. The Kaplan–Meier curve and Cox regression were employed to determine miR-195-5p′s prognostic significance. In vitro, the effects of miR-195-5p mimic or inhibitor on VSMC proliferation and migration were assessed using CCK-8 and Transwell assays. Results In CAS patients, serum miR-195-5p levels were elevated and correlated with the degree of CAS. The ROC curve had an AUC value of 0.897, with sensitivity of 71.4% and specificity of 95.4%. Higher levels of miR-195-5p indicated a higher risk of CIE occurrence and may serve as an independent predictor of CIE. The upregulation of miR-195-5p promoted VSMC proliferation and migration, while downregulation had the opposite effect. Conclusions miR-195-5p was demonstrated to have diagnostic and prognostic significance in CAS and may serve as a potential biomarker. It may contribute to the progression of CAS by promoting the proliferation and migration of VSMCs.
A rare presentation of bone cement implantation syndrome as hypertensive anaphylaxis: A diagnostic and management dilemma
Authors: Neeradi Vishal Kumar , Aluka Sandeep Kund Reddy , Katroth Chander , Bora Hemalatha , Sultana Tarannum , Maremanda Krishna Rao 
Published: August 2024

Background: Bone cement implantation syndrome characteristically involves acute alterations in the function of respiratory and cardiovascular systems. We present a case report of cement reaction with unusual presentation, that is, hypoxia, hypertension and tachycardia. A 74-year-old hypertensive male on regular medications sustained a slip and fall, presented with a right intertrochanteric neck of femur fracture, now posted for cemented hemiarthroplasty. Intraoperatively, after applying bone cement, the patient developed sweating, dyspnoea, bilateral wheezing and tachypnoea and desaturation of up to 80%–84%. Respiratory symptoms were associated with tachycardia (140–160 bpm) and hypertension (220/110 mm Hg). The surgeon was alerted about the event, the patient was reassured, and respiration was assisted with positive pressure ventilation with supplementation of 100% oxygen. Discussion: Several mechanisms have been proposed, such as the toxic effect of systemically absorbed methyl methacrylate, exothermic reaction, fat and marrow embolism, high marrow pressure during cementing and anaphylactic reaction. The administration of adrenaline, which can worsen the clinical picture, is the mainstay in managing anaphylaxis. Conclusion: The association of hypertension and tachycardia with bone cement implantation syndrome, previously not reported, can have distinct pathomechanisms and cause a diagnostic and management dilemma.
Comparing remote versus in-person assessment of learning skills in children with specific learning disabilities
Authors: Lampis Valentina , Dondena Chiara , Mauri Chiara , Villa Martina , Salandi Antonio , Molteni Massimo , Cantiani Chiara , Mascheretti Sara 
Published: August 2024

Background Interactive telemedicine applications have been progressively introduced in the assessment of cognitive and literacy skills. However, there is still a lack of research focusing on the validity of this methodology for the neuropsychological assessment of children with Specific Learning Disorder (SLD). Methods Seventy-nine children including 40 typically developing children (18 males, age 11.5 ± 1.06) and 39 children with SLD (24 males, age 12.3 ± 1.28) were recruited. Each participant underwent the same neuropsychological battery assessing reading accuracy, speed, and comprehension, writing, numerical processing, computation, and semantic numerical sense, twice (once during an in-person session (I) and once during a remote (R) home-based videoconference session). Four groups were subsequently defined based on the administration order. Repeated-measure-ANOVAs with assessment type (R vs. I testing) as within-subject factor and diagnosis (SLD vs. TR) and administration order (R-I vs. I-R) as between-subject factors, and between-group t-tests comparing the two assessment types within each time of administration, were run. Results No differences emerged between I and R assessments of reading accuracy and speed, numerical processing, and computation; on the contrary, potential biases against R assessment emerged when evaluating skills in writing, reading comprehension, and semantic numerical sense. However, regardless of the assessment type, the scores obtained with I and R assessments within the same administration time point overlapped. Discussion These results partially support the validity and reliability of the assessment of children's learning skills via a remote home-based videoconferencing system. Implementing telemedicine as an assessment tool may increase timely access to primary health care and to support research activity.
The positive predictive value of MOG-IgG testing based on the 2023 diagnostic criteria for MOGAD
Authors: Nguyen Linda , Singh Sumit , Feltrin Fabricio S , Tardo Lauren M , Clarke Rebekah L , Wang Cynthia X , Greenberg Benjamin M 
Published: August 2024

Background Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is a relatively new disease entity in the field of demyelinating disorders. Its first diagnostic criteria have recently been published. Objectives We evaluated the positive predictive value (PPV) for MOG-IgG testing and report the clinical and radiologic features with respect to the recently published criteria. Methods A retrospective study was conducted at three centers in Dallas, Texas. Patients with positive MOG-IgG testing on cell-based assays at any time were included. Positive cases were reviewed by at least two neuroimmunologists for fulfillment of the criteria. Results We included 235 patients. The PPV of seropositivity at any time was 78.3% overall, 52.6% for low titer, and 90.1% for high titer. Children had a higher PPV than adults (93.9% versus 67.2%). Positive predictive value was 6.3% in those without a core clinical demyelinating attack. Children more often have the typical imaging features of MOGAD in optic neuritis than adults. Conclusions We report a PPV of 78.3% for MOG-IgG testing using the 2023 MOGAD diagnostic criteria. Children had higher PPV and frequency of supporting imaging features. Careful consideration is necessary when assigning patients with no core demyelinating event and low titers a MOGAD diagnosis.
Patient Preferences for Graft Selection in Anterior Cruciate Ligament Reconstruction
Authors: Pearsall Christian , Chen Aaron Z. , Abdelaziz Abed , Saltzman Bryan M. , Piasecki Dana P. , Popkin Charles A. , Redler Lauren H. , Levine William N. , Ahmad Christopher S. , Trofa David P. 
Published: August 2024

Background: Selecting an appropriate graft for anterior cruciate ligament (ACL) reconstruction requires consideration of a patient's preferences, goals, age, and physical demands alongside the risks and benefits of each graft choice. Purpose: To determine the most popular ACL reconstruction grafts among patients and the most important factors influencing their decisions. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Patients undergoing ACL reconstruction between October 2022 and April 2023 completed a survey either before (nonconsult group) or after (consult group) speaking with their surgeon, who provided an evidence-based description of the pros and cons of an allograft and the following autografts: bone-patellar tendon-bone (BPTB), hamstring tendon (HT), and quadriceps tendon (QT). Patient characteristics, graft choice, information influencing their graft choice, and surgeon recommendation were collected and compared between the groups. Results: Among the 100 included patients, 59.0% were male, and the mean age was 28.3 ± 10.4 years. The most popular grafts were the BPTB (56.0%), followed by the QT (29.0%), HT (8.0%), and allograft (7.0%). No significant difference was observed in the graft selection between the consult group (n = 60; BPTB, 46.7%; QT, 38.3%; HT, 8.3%; allograft, 6.7%) and nonconsult group (n = 40; BPTB, 70.0%; QT, 15.0%; HT, 7.5%; allograft, 7.5%) ( P = .0757). In the consult group, 81.7% of patients selected the graft recommended to them by their surgeon. The top 2 graft selection reasons were usage in professional athletes and failure rates, while the top 2 ACL surgery concerns were returning to their desired level of athletics and graft failure risk. Among the 93 patients who researched their ACL graft options before their visit, the most popular information source was some form of media (72.0% [67/93]). Conclusion: The study findings underscore the importance of patient preference and surgeon recommendation in a patient's graft selection and highlight the need to be cognizant of the information sources available to patients when researching their graft options.
Incidence of Osteoarthritis Between ACL Reconstruction With Different Graft Types and Between ACL Reconstruction and Repair: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Vendrig Tom , Keizer Michèle N.J. , Brouwer Reinoud W. , Hoogeslag Roy A.G. 
Published: August 2024

Background: Variation in stiffness, fixation methods, and donor-site morbidity after anterior cruciate ligament reconstruction (ACLR) with different graft types and with anterior cruciate ligament suture repair (ACLSR) can lead to differences in dynamic knee laxity and consequent differences in posttraumatic osteoarthritis (PTOA) development. Purpose: To compare the incidence of PTOA between different graft types used for primary ACLR and between primary ACLR and ACLSR. It was hypothesized that the incidence of PTOA would vary between ACLR with different autografts and allografts and between ACLR and ACLSR. Study Design: Systematic review; Level of evidence, 1. Methods: A search of the literature was performed to identify all randomized controlled trials (RCTs) comparing radiographic evidence of PTOA after ACLR between different graft types—hamstring tendon (HT) autograft, bone-patellar tendon-bone (BPTB) autograft, quadriceps tendon autograft, and allograft—and between ACLR and ACLSR. The minimum follow-up was 2 years. Study quality was assessed using the modified Coleman Methodology Score. A meta-analysis was performed to determine whether there was a difference in the incidence of PTOA between the different graft types and between ACLR and ACLSR. Results: Eleven randomized controlled trials were included in the meta-analysis—HT: 440 patients (mean follow-up, 9.7 years); BPTB: 307 patients (mean follow-up, 11.8 years); allograft: 246 patients (mean follow-up, 5 years); ACLSR, 22 patients (5 years). No study reporting the incidence after ACLR with quadriceps tendon was included. The study quality ranged from 70 to 88. The meta-analysis indicated no significant difference in the incidence of PTOA between graft types used for ACLR and between ACLR and ACLSR (risk ratios: HT vs BPTB, 1.05; HT vs allograft, 0.81; BPTB vs allograft, 0.82; HT vs ACLSR, not estimable [ P > .05 for all]). The combined number of patients with PTOA in all studies per graft type showed that patients who underwent ACLR with a BPTB autograft had the highest percentage of PTOA (HT, 23.4%; BPTB, 29.6%; allograft, 8.1%; ACLSR, 0%). However, excluding studies with a follow-up <5 years resulted in similar outcomes for patients with an HT autograft and a BPTB autograft. Conclusion: This meta-analysis reported no difference in the incidence of PTOA between graft types used for ACLR and between ACLR and ACLSR. More research is necessary to make a reliable conclusion about which technique is associated with the lowest incidence of PTOA after ACL surgery.
The Role of Humeral Torsion on Glenohumeral Rotation in Injured Baseball Players
Authors: Entler Kalie , Kruseman J. Kaylin , Kennedy Sean M. , Conway John E. , Reyes Griffin J. , Garrison J. Craig , Bailey Lane B. , Myers Natalie L. 
Published: August 2024

Background: Differences in rotational range of motion (ROM) compared to humeral retrotorsion (HRT)–corrected rotational ROM exist in healthy baseball athletes, but it is unclear whether these differences exist in a pathological population. Purpose/Hypothesis: The purpose of this study was to determine if there are disparities between objectively measured differences in ROM and HRT-corrected deficits in injured baseball players. It was hypothesized that disparities would exist between (1) the side-to-side difference in glenohumeral external rotation (GER) and the HRT-corrected glenohumeral external rotation deficit (GERD) and (2) the side-to-side difference in glenohumeral internal rotation (GIR) and the HRT-corrected glenohumeral internal rotation deficit (GIRD). Study Design: Cross-sectional study; Level of evidence, 3. Methods: Data from 172 baseball players with shoulder or elbow injuries (45 shoulder, 127 elbow) were reviewed in July 2023. GER and GIR were measured on the injured and noninjured sides of all players, and diagnostic ultrasound was used to measure HRT. Dependent t tests were run to compare the side-to side differences in GER and GIR with the HRT-corrected GERD and GIRD, respectively. Results: In the players with a shoulder injury, there was a significant disparity between the side-to-side difference in GER and the HRT-corrected GERD (2°± 14° vs −13°± 15°, respectively) and between the side-to-side difference in GIR and the HRT-corrected GIRD (–14°± 8° vs 2°± 9°, respectively) ( P < .001 for both). Similarly, players with an elbow injury had significant disparities between the side-to-side difference in GER and the HRT-corrected GERD (6°± 9° vs −10°± 9°, respectively) and between the side-to-side difference in GIR and the HRT-corrected GIRD (–12°± 8° vs 4°± 10°, respectively) ( P < .001 for both). Conclusion: The results supported our hypothesis that there were disparities between objectively measured differences in GER and GIR compared with the HRT-corrected GERD and GIRD in injured baseball players. Consideration must be given to osseous adaptations that occur at the glenohumeral joint when evaluating and treating this population.
Phenytoin relieves acute exacerbations of trigeminal neuralgia: Results of a retrospective case series
Authors: Kolakowski Lukasz , Pohl Heiko , Kleinsorge Marie Therese , Wegener Susanne 
Published: August 2024

Introduction The management of acute exacerbations of trigeminal neuralgia remains a major clinical challenge due to the limited availability of clinical evidence. This retrospective case series aims to evaluate the effectiveness and safety of intravenous phenytoin in the treatment of these exacerbations. Methods We retrospectively analyzed the outcome of patients treated with intravenous phenytoin for acute exacerbations of trigeminal neuralgia at the University Hospital Zurich between January 2016 and December 2023. Statistical analyses were performed to assess the associations of patient and disease characteristics with phenytoin response. Results In our sample of 45 cases, treatment with phenytoin resulted in a significant or complete relief in 30 cases (66.7%), while 11 (24.4%) experienced slight relief and 4 (8.9%) none. Patient or disease characteristics were not associated with treatment response. Side effects were rare, with skin itching occurring in only one case. Conclusion This retrospective case series demonstrates, that phenytoin is a safe and effective treatment for acute exacerbations of trigeminal neuralgia. However, larger prospective studies are needed.
A systematic review of procedural and sampling techniques for cryobiopsy in interstitial lung disease
Authors: Lachowicz Julia A. , Smallwood Natasha E. , Prasad Jyotika D. , Patel Purab , Voutier Catherine , Khor Yet H. , Steinfort Daniel P. 
Published: August 2024

BackgroundTransbronchial lung cryobiopsy (TBLC) is an alternative to surgical lung biopsy for histopathological evaluation of unclassifiable interstitial lung disease (ILD) or ILD diagnosed with low confidence. This meta-analysis synthesised current literature regarding cryobiopsy diagnostic performance and safety, focusing on procedural and sampling techniques.MethodsMedline and Embase were searched on 11 April 2022. Studies included adults with unclassifiable ILD, reporting diagnostic yield, complications and methodological techniques of TBLC. Meta-analyses were performed for diagnostic yield, pneumothorax and bleeding. Subgroup analyses and meta-regression assessed methodological variables. PROSPERO registration: CRD42022312386.Results70 studies were included with 6183 participants. Diagnostic yield of TBLC was 81% (95% CI 79–83%, I2=97%), with better yield being observed with general anaesthesia (p=0.007), ILD multidisciplinary meeting prior to cryobiopsy (p=0.02), 2.4 mm cryoprobe (p=0.04), higher mean forced vital capacity (p=0.046) and higher mean diffusing capacity for carbon monoxide (p=0.023). Pneumothorax rate was 5% (95% CI 4–5%, I2=91%), with higher rates associated with a 2.4 mm cryoprobe (p<0.00001), routine post-procedure imaging (p<0.00001), multiple lobe sampling (p<0.0001), reduced mean diffusing capacity for carbon monoxide (p=0.028) and general anaesthesia (p=0.05). Moderate-to-severe bleeding rate was 12% (11–14%, I2=95%) and higher rates were associated with a 2.4 mm cryoprobe (p=0.001) and bleeding score selection (p=0.04).InterpretationPatient characteristics and modifiable factors, including procedural methods and anaesthetic techniques, impacted diagnostic yield and safety outcomes of TBLC in people with unclassifiable ILD and contributed to heterogeneity of clinical outcomes. These variables should be considered for individualised clinical decision making and guideline development and warrant routine reporting in future research.