bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Potential Prognostic Markers for Knee Osteoarthritis by Serum Proteomic Analysis
Authors: Takinami Yoshihiko , Yoshimatsu Shinya , Uchiumi Takaoki , Toyosaki-Maeda Tomoko , Morita Atsushi , Ishihara Takeshi , Yamane Shoji , Fukuda Isao , Okamoto Hiroyuki , Numata Yoshito , Fukui Naoshi 
Published: July 2013

Background As osteoarthritis (OA) is a highly heterogeneous disease in terms of progression, establishment of prognostic biomarkers would be highly beneficial for treatment. The present study was performed to identify novel biomarkers capable of predicting the progression of knee OA. Methods A total of 69 plasma samples (OA patients undergoing radiographic progression, n = 25; nonprogression, n = 33; healthy donors, n = 11) were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), and ion peaks of interest were identified by liquid chromatography and matrix-assisted laser desorption/ionization (MALDI)-TOF MS. The identities of these proteins were further validated by immunoprecipitation combined with SELDI-TOF MS analysis. Results SELDI-TOF MS analysis indicated that the intensities of 3 ion peaks differed significantly between progressors and nonprogressors. Subsequent analyses indicated that these peaks corresponded to apolipoprotein C-I, C-III, and an N-terminal truncated form of transthyretin, respectively. The identities of these proteins were confirmed by the loss of ion peaks in SELDI-TOF MS spectra by immunoprecipitation using specific antibodies for the respective proteins. Conclusions Three potential biomarkers were identified whose serum levels differed significantly between OA progressors and nonprogressors. These biomarkers are expected to be prognostic biomarkers for knee OA and to facilitate the development of novel disease-modifying treatments for OA.
Editorial to the Special Issue
Authors: Niechoj Torsten , van Treeck Till 
Published: July 2013

First paragraph
The financial market crisis that transformed into a global recession is a challenge for both economic theory and policy. In retrospect, nearly three years after the first signs of the crisis, a few tentative conclusions concerning the appropriateness and effectiveness of the responses to the crisis might be possible. After an initial state of shock, the political system acted forcefully and issued programmes to stabilise both financial sector and the real economy all over the world. Moreover, governments started to talk about an encompassing regulation of the financial sector, which was supported by many economists. This is indeed remarkable compared to what used to be common sense in the years before within advisory bodies – among others the European Commission, the IMF and academic think tanks. Privatisation and liberalisation of markets were, then, thought to be key to increasing the capacity of the economy to absorb shocks and to guarantee high growth rates and economic well-being. Although in that respect politicians and economists obviously did learn from the crisis and began to take seriously alternative ideas which had for a long time been absent in the debates, a ›return to normality‹ is already imminent; the planned fiscal retrenchment programmes, particularly within the European Union, and the deferral of regulatory measures for financial markets are testament to this. The king is dead, long live the king? From today's view it is not clear whether or not, in the longer run, this crisis has really shaken the foundations of economic thinking and policy making.
Editorial to the Special Issue
Authors: Arestis Philip 
Published: July 2013

First paragraph
This special issue of Intervention. European Journal of Economics and Economic Policies is devoted to Geoff Harcourt, self-proclaimed Australian patriot and Cambridge economist. His work is squarely within the Political Economy approach to economics. In 2010 Geoff Harcourt decided to return back to his Australian roots and it is for this reason that the organisers of the 7th international conference, Developments in Economic Theory and Policy, Bilbao (Spain), 1–2 July 2010, Department of Applied Economics V, University of the Basque Country, and Cambridge Centre for Economic and Public Policy, University of Cambridge, set up two sessions to celebrate Geoff Harcourt's work. The editors of Intervention very kindly offered to publish the proceedings of the two sessions in this issue. Not only did Geoff Harcourt attend the conference, he also contributed to the sessions. This special issue begins with his contribution.
Incomes policy: Two approaches
Authors: Sardoni Claudio 
Published: July 2013

Post-Keynesians in general, and Geoff Harcourt in particular, have always laid much emphasis on incomes policies, which allow policy-makers to implement expansionary demand-side policies and ensure price stability. Mainstream economics, instead, gives little, if any, relevance to incomes policies. The central bank's monetary policy is the main tool to be used to ensure price stability. In the mainstream approach, price stability is ensured by constraining the economy's level of output and employment below full employment. This can be defined as the mainstream implicit incomes policy.
This article argues that policy indications different from the mainstream can be derived. This, in particular, is done by removing the typical hypothesis that, in the short period, productivity is constant and independent of variations of aggregate output. This sort of approach allows for non-inflationary demand expansionary policies, which at the same time can promote the productivity and efficiency of the economy as a whole. This line of analysis is largely influenced by the work of Geoff Harcourt.
Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance
Authors: Kim Dae Hwan , Shin Nari , Kim Gwang Ha , Song Geum Am , Jeon Tae-Yong , Kim Dong-Heon , Lauwers Gregory Y. , Park Do Youn 
Published: July 2013

Context.—The clinical validity of mucin expression in gastric cancer is debated. Whereas several reports demonstrate a correlation between mucin expression and prognosis, others deny such an association.
Objectives.—This survival analysis study aims to elucidate the prognostic significance of mucin expression in gastric cancer.
Design.—A retrospective survival analysis was done with 412 cases of gastric cancer characterized on the basis of MUC immunohistochemistry using MUC2, MUC5AC, MUC6, and CD10 antibodies; the cases were divided into those with a gastric, an intestinal, or a null mucin phenotype based on the predominant mucin.
Results.—There was no association between mucin expression and survival when considering overall gastric cancers or the advanced gastric cancer subtype. However, early gastric cancers with a gastric mucin phenotype showed longer survival than those with an intestinal mucin phenotype (P = .01) or a null phenotype (P = .01). In particular, MUC5AC-positive early gastric cancers resulted in longer survival than did those that did not express MUC5AC (P = .009). The loss of MUC5AC expression was identified as an independent, poor prognostic factor in early gastric cancers using the Cox regression proportional hazard model (hazard ratio, 3.50; P = .045).
Conclusions.—MUC5AC expression is significantly associated with patient survival and can be used to predict outcomes in the gastric cancers, especially in the early gastric cancers.
Un parcours pluridisciplinaire dans les Grassfields du Cameroun
Authors: Warnier Jean-Pierre 
Published: July 2013

En 1985, l’auteur publiait un livre intitulé Échanges, développement et hiérarchies dans le Bamenda précolonial – Cameroun. Quinze ans plus tard, il est apparu que ce livre marchait sur la tête. Pour pasticher Marx : il fallait le remettre sur ses pieds. L’auteur se propose ici de faire le récit de ce renversement. L’objectif est de faire l’analyse d’un terrain africain – celui des Grassfields du Cameroun – et de voir comment celle-ci a été reformulée à plusieurs reprises au fil de quarante années de montée en puissance des recherches effectuées dans de multiples disciplines, entraînant des changements de paradigmes anthropologiques dans le sens d’une interdisciplinarité de plus en plus affirmée.
Mort, autopsie et funérailles chez les Dìì de l’Adamaoua (Nord-Cameroun)
Authors: Muller Jean-Claude 
Published: July 2013

Cet article décrit les changements apportés aux rites de décès, autopsies et deuils chez les Dìì depuis que nous avons sur eux des documents écrits qui datent maintenant d’un peu plus de cent ans. Malgré des modifications importantes, une caractéristique cruciale s’est – en règle générale – maintenue malgré la différenciation religieuse entre traditionalistes, chrétiens et musulmans : le régime communautaire des cimetières.
La polyphonie textuelle balzacienne en espagnol et en anglais
Authors: Zambrano Carballo Pablo 
Published: July 2013

Définie par Balzac lui-même comme « l’oeuvre capitale dans l’oeuvre », Illusions perdues révèle la plupart les stratégies, thématiques, narratives et stylistiques mises en oeuvre dans La comédie humaine. L’une de ces stratégies est la reproduction fidèle d’une grande variété de discours oraux et écrits. Le présent article fait état, en premier lieu, d’une analyse de la relation entre le concept aristotélicien de la mimesis et la technique réaliste de la vraisemblance, que Balzac fait reposer en grande partie sur des bases linguistiques et métalinguistiques. Par ailleurs, grâce à une comparaison de diverses traductions espagnoles et anglaises d’Illusions perdues, l’article examine une sélection représentative des discours contenus dans le roman et souligne l’importance capitale, pour les traducteurs, d’être conscients de la variété des styles dans l’oeuvre balzacienne, afin de restituer dans les langues d’arrivée un effet de vraisemblance comparable à celui de l’original.
PECONPI: A novel software for uncovering pathogenic copy number variations in non‐syndromic sensorineural hearing loss and other genetically heterogeneous disorders
Authors: Tsai Ellen A. , Berman Micah A. , Conlin Laura K. , Rehm Heidi L. , Francey Lauren J. , Deardorff Matthew A. , Holst Jenelle , Kaur Maninder , Gallant Emily , Clark Dinah M. , Glessner Joseph T. , Jensen Shane T. , Grant Struan F.A. , Gruber Peter J. , Hakonarson Hakon , Spinner Nancy B. , Krantz Ian D. 
Published: July 2013

ABSTRACTThis report describes an algorithm developed to predict the pathogenicity of copy number variants (CNVs) in large sample cohorts. CNVs (genomic deletions and duplications) are found in healthy individuals and in individuals with genetic diagnoses, and differentiation of these two classes of CNVs can be challenging and usually requires extensive manual curation. We have developed PECONPI, an algorithm to assess the pathogenicity of CNVs based on gene content and CNV frequency. This software was applied to a large cohort of patients with genetically heterogeneous non‐syndromic hearing loss to score and rank each CNV based on its relative pathogenicity. Of 636 individuals tested, we identified the likely underlying etiology of the hearing loss in 14 (2%) of the patients (1 with a homozygous deletion, 7 with a deletion of a known hearing loss gene and a point mutation on the trans allele and 6 with a deletion larger than 1 Mb). We also identified two probands with smaller deletions encompassing genes that may be functionally related to their hearing loss. The ability of PECONPI to determine the pathogenicity of CNVs was tested on a second genetically heterogenous cohort with congenital heart defects (CHDs). It successfully identified a likely etiology in 6 of 355 individuals (2%). We believe this tool is useful for researchers with large genetically heterogeneous cohorts to help identify known pathogenic causes and novel disease genes. © 2013 Wiley Periodicals, Inc.
Pure duplication of 19p13.3
Authors: Ishikawa Aki , Enomoto Keisuke , Tominaga Makiko , Saito Toshiyuki , Nagai Jun‐ichi , Furuya Noritaka , Ueno Kentaro , Ueda Hideaki , Masuno Mitsuo , Kurosawa Kenji 
Published: July 2013

ABSTRACTChromosomal abnormalities involving 19p13.3 have rarely been described in the published literature. Here, we report on a girl with a pure terminal duplication of 6.1 Mb on 19p13.3, caused by an unbalanced translocation der(19)t(10;19)(qter;p13.3)dn. Her phenotype included severe psychomotor developmental delay, skeletal malformations, and a distinctive facial appearance, similar to that of a patient previously reported by Lybaek et al. [Lybaek et al. (2009); Eur J Hum Genet 17:904–910]. These results suggest that a duplication of >3 Mb at the terminus of 19p13.3 might represent a distinct chromosomal syndrome. © 2013 Wiley Periodicals, Inc.
Missense mutations in FBN1 exons 41 and 42 cause Weill–Marchesani syndrome with thoracic aortic disease and Marfan syndrome
Authors: Cecchi Alana , Ogawa Naomi , Martinez Hugo R. , Carlson Alicia , Fan Yuxin , Penny Daniel J. , Guo Dong‐chuan , Eisenberg Steven , Safi Hazim , Estrera Anthony , Lewis Richard A. , Meyers Deborah , Milewicz Dianna M. 
Published: July 2013

AbstractMutations in FBN1 cause a range of overlapping but distinct conditions including Marfan syndrome (MFS), Weill–Marchesani syndrome (WMS), familial thoracic aortic aneurysms/dissections (FTAAD), acromicric dysplasia (AD), and geleophysic dysplasia (GD). Two forms of acromelic dysplasia, AD and GD, characterized by short stature, brachydactyly, reduced joint mobility, and characteristic facies, result from heterozygous missense mutations occurring in exons 41 and 42 of FBN1; missense mutations in these exons have not been reported to cause MFS or other syndromes. Here we report on probands with MFS and WMS who have heterozygous FBN1 missense mutations in exons 41 and 42, respectively. The proband with WMS has ectopia lentis, short stature, thickened pinnae, tight skin, striae atrophicae, reduced extension of the elbows, contractures of the fingers and toes, and brachydactyly and has a missense mutation in exon 42 of FBN1 (c.5242T>C; p.C1748R). He also experienced a previously unreported complication of WMS, an acute thoracic aortic dissection. The second proband displays classic characteristics of MFS, including ectopia lentis, skeletal features, and aortic root dilatation, and has a missense mutation in exon 41 of FBN1 (c.5084G>A; p.C1695Y). These phenotypes provide evidence that missense mutations in exons 41 and 42 of FBN1 lead to MFS and WMS in addition to AD and GD and also suggest that all individuals with pathogenic FBN1 mutations in these exons should be assessed for thoracic aortic disease and ectopia lentis. Further studies are necessary to elucidate the factors responsible for the different phenotypes associated with missense mutations in these exons of FBN1. © 2013 Wiley Periodicals, Inc.
Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus
Authors: Sparrow Duncan B. , Faqeih Eissa Ali , Sallout Bahauddin , Alswaid Abdulrahman , Ababneh Faroug , Al‐Sayed Moeenaldeen , Rukban Hadeel , Eyaid Wafaa M. , Kageyama Ryoichiro , Ellard Sian , Turnpenny Peter D. , Dunwoodie Sally L. 
Published: July 2013

AbstractSpondylocostal dysotosis (SCD) is a rare developmental congenital abnormality of the axial skeleton. Mutation of genes in the Notch signaling pathway cause SCD types 1–5. Dextrocardia with situs inversus is a rare congenital malformation in which the thoracic and abdominal organs are mirror images of normal. Such laterality defects are associated with gene mutations in the Nodal signaling pathway or cilia assembly or function. We investigated two distantly related individuals with a rare combination of severe segmental defects of the vertebrae (SDV) and dextrocardia with situs inversus. We found that both individuals were homozygous for the same mutation in HES7, and that this mutation caused a significant reduction of HES7 protein function; HES7 mutation causes SCD4. Two other individuals with SDV from two unrelated families were found to be homozygous for the same mutation. Interestingly, although the penetrance of the vertebral defects was complete, only 3/7 had dextrocardia with situs inversus, suggesting randomization of left–right patterning. Two of the affected individuals presented with neural tube malformations including myelomeningocele, spina bifida occulta and/or Chiari II malformation. Such neural tube phenotypes are shared with the originally identified SCD4 patient, but have not been reported in the other forms of SCD. In conclusion, it appears that mutation of HES7 is uniquely associated with defects in vertebral, heart and neural tube formation, and this observation will help provide a discriminatory diagnostic guide in patients with SCD, as well as inform molecular genetic testing. © 2013 Wiley Periodicals, Inc.
Ecology of reproduction in Sanje mangabeys (Cercocebus sanjei): Dietary strategies and energetic condition during a high fruit period
Authors: McCabe Gráinne Michelle , Fernández David , Ehardt Carolyn L. 
Published: July 2013

AbstractThe ability to increase energy storage when food is abundant for later use during late gestation and early lactation is often considered the primary benefit of the capital breeding strategy (clustering conceptions during high food periods, HFP) that promotes reproductive success among females living in unpredictable environments. Capital breeding, however, may also enable preconceptive females to increase hormone production for ovulation, which has been linked to energetic condition in capital breeders, and/or allow females entering the subsequent HFP to increase their energetic condition in order to continue nursing unweaned infants. Here, we investigate whether capital breeding provides these additional benefits in 16 female Sanje mangabeys (Cercocebus sanjei) and determine the dietary strategies used to increase energetic condition (measured by urinary C‐peptide: UCP) during the HFP. Fecal estradiol (fE2) and UCP were negatively correlated with number of cycles before conception (r = −0.591, r = −0.646, P < 0.01) and were highest in conceptive cycles. Both peri‐conceptive (preconception and early gestation) and non‐peri‐conceptive (lactation) females increased energetic condition over the HFP (r = 0.612, r = 0.583, P < 0.001) by increasing dietary fat (r = 0.619, r = 0.703, P < 0.001) and, for non‐peri‐conceptive females, protein (r = 0.437, P < 0.001). Feeding intake rate (FIR) and time spent foraging and feeding did not change over the HFP; however, non‐peri‐conceptive females exhibited a faster FIR compared to peri‐conceptive females (t = −2.324, P < 0.05), consuming almost twice as much food per unit time. The results of this study confirm that Sanje mangabeys benefit in multiple phases of the reproductive cycle by using capital breeding, which may explain how this strategy promotes female reproductive success. Am. J. Primatol. 75:1196–1208, 2013. © 2013 Wiley Periodicals, Inc.
Effects of blending time and catalyst on the properties of nylon 1010/acrylate rubber blends
Authors: Lu Xianbo , Zhang Hongmei , Zhang Yong 
Published: July 2013

ABSTRACTNylon 1010 and acrylate rubber (ACM) were prepared by melt blending. The effects of blending time and catalyst on the properties of the blends were studied. It was found that ester‐amide exchange reactions between the Nylon 1010 and ACM occurred during melt processing. Long blending time and Tetrabutyl titanate (Ti(OBu)4) as a catalyst could promote the reactions, and grafted copolymer Nylon‐g‐ACM was in situ generated as a compatibilizer during processing procedure. The tensile strength of the blends increased from about 12.0–15.0 MPa when the blending time increased from 10 to 30 min. The presence of Ti(OBu)4 led to the decrease in melt flow index (MFI), independent of the blending time (30 or 60 min). Glass transition temperature and heat of fusion of the blends increased after addition of the catalyst. Rheological behavior analysis provided evidence of formation of Nylon‐g‐ACM graft copolymer. Scanning electron microscopy (SEM) showed that the compatibility of the blends was improved by longer blending time and the addition of catalyst. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4587–4597, 2013
Lightly branched poly(vinyl alcohol) for fluid loss additive
Authors: Han Haifeng , Zhang Junhua 
Published: July 2013

ABSTRACTOne kind of branched Poly(vinyl alcohol) has been synthesized via common radical copolymerization of vinyl acetate in methanol by adding a bifunctional monomer Allyl methacrylate (AMA) followed by saponification. The comonomer AMA has two reactive double bonds that can provide the branching points to macromolecule chain structure. With these reactive points, the copolymer with long chain branches can be obtained. The long chain branches bring the copolymer higher viscosity by the entanglement of them between macromolecules and strong hydrogen bonding between long chain branches. The viscosity of the water solutions increased with the amount of the comonomers' addition increased. The branched PVA has good water maintenance properties at relatively high temperature. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4608–4612, 2013
TAT‐modified mixed micelles as biodegradable targeting and delivering system for cancer therapeutics
Authors: Li Xiaoyuan , Wang Mingzhe , Liu Changbai , Jing Xiabin , Huang Yubin 
Published: July 2013

ABSTRACTA mixed micellar system of novel function was designed and synthesized by co‐assembling TAT (cell penetrating peptide)‐modified poly (ethylene glycol)‐poly(l‐lactide) (PEG‐PLA) copolymer with the drug‐conjugated poly(ethylene glycol)‐b‐poly(l‐lactide‐co‐2‐methyl‐2‐carboxyl‐propylene carbonate) (mPEG‐b‐P(LA‐co‐MCC)) copolymer. UV‐Vis, Matrix‐assisted laser desorption/ionization time‐of‐flight, and XPS were used to ensure the successful modification of the copolymers with TAT and anti‐tumor drugs. The size of spherical nanomicelles increased from 50 to 60 nm as of empty polymeric micelles to 100–150 nm as of drug‐loaded ones, determined by dynamic light scattering and TEM. Daunorubicin was selected as model drug for in vitro evaluations on different cell lines. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay clearly indicated an improved cell growth inhibition of the TAT‐modified mixed micelles. While green fluorescent protein was used as a marker for the mixed micelle, small amount of DMSO was necessary to enhance the accumulation of the mixed micelles in cell lines Caski. Mediated by TAT, mixed micelles containing Apoptin (a tumor‐specific apoptosis drug) showed higher level of tumor cell internalization and growth inhibition than that of mixed micelles without TAT modification. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4598–4607, 2013