bluuebunny/crossref_metadata_2025_split huggingface dataset:
90Yttrium-Ibritumomab-Tiuxetan as First-Line Treatment for Follicular Lymphoma: 30 Months of Follow-Up Data From an International Multicenter Phase II Clinical Trial
Authors: Scholz Christian W. , Pinto Antonello , Linkesch Werner , Lindén Ola , Viardot Andreas , Keller Ulrich , Hess Georg , Lastoria Secondo , Lerch Kristina , Frigeri Ferdinando , Arcamone Manuela , Stroux Andrea , Frericks Bernd , Pott Christiane , Pezzutto Antonio 
Published: December 2012

Purpose We report on a multicenter phase II trial of 90yttrium-ibritumomab-tiuxetan (90YIT) as first-line stand-alone therapy for patients with follicular lymphoma (FL). Patients and Methods Fifty-nine patients with CD20+ FL grade 1 to 3a in stages II, III, or IV, age 50 years old or older requiring therapy were enrolled. They received 90YIT according to standard procedure. If complete response (CR) or unconfirmed complete response (CRu) without evidence for minimal residual disease (MRD) 6 months after application of 90YIT was achieved, patients were observed without further intervention. The same applied to patients with partial response (PR) or with stable disease (SD). Patients with CR but with persisting MRD were to receive a consolidation treatment with rituximab. Primary end point was the clinical and molecular response rate. Secondary end points were time to progression, safety, and tolerability. Results Six months after treatment with 90YIT, 56% of the patients showed a CR or CRu and 31% achieved a PR. After a median follow-up of 30.6 months, the progression-free survival (PFS) was 26 months. There was a trend for shorter PFS in patients with increased lactate dehydrogenase (LDH). Of the 26 patients who had CR 12 months after 90YIT, only three had relapsed. Median time to next treatment has not been reached. The most common toxicities were transient thrombocytopenia and leukocytopenia. Nonhematologic toxicities never exceeded grade 2 according to Common Terminology Criteria for Adverse Events (CTCAE v2.0). Conclusion 90YIT is well tolerated and achieves high response rates. Patients with increased LDH tend to relapse earlier, and individuals in remission 1 year after 90YIT appear to have long- lasting responses.
Persistent Overall Survival Benefit and No Increased Risk of Second Malignancies With Bortezomib-Melphalan-Prednisone Versus Melphalan-Prednisone in Patients With Previously Untreated Multiple Myeloma
Authors: San Miguel Jesús F. , Schlag Rudolf , Khuageva Nuriet K. , Dimopoulos Meletios A. , Shpilberg Ofer , Kropff Martin , Spicka Ivan , Petrucci Maria Teresa , Palumbo Antonio , Samoilova Olga S. , Dmoszynska Anna , Abdulkadyrov Kudrat M. , Delforge Michel , Jiang Bin , Mateos Maria-Victoria , Anderson Kenneth C. , Esseltine Dixie-Lee , Liu Kevin , Deraedt William , Cakana Andrew , van de Velde Helgi , Richardson Paul G. 
Published: December 2012

Purpose This final analysis of the phase III VISTA trial (Velcade As Initial Standard Therapy in Multiple Myeloma: Assessment With Melphalan and Prednisone) was conducted to determine whether the overall survival (OS) benefit with bortezomib-melphalan-prednisone (VMP) versus melphalan-prednisone (MP) in patients with myeloma who were ineligible for transplantation was maintained after 5 years of follow-up and to explore the risk of second primary malignancies. Patients and Methods In all, 682 patients received up to nine 6-week cycles of VMP or MP and were then observed every 12 weeks or less. Data on second primary malignancies were collected by individual patient inquiries at all sites from 655 patients. Results After median follow-up of 60.1 months (range, 0 to 74 months), there was a 31% reduced risk of death with VMP versus MP (hazard ratio [HR], 0.695; P < .001; median OS 56.4 v 43.1 months). OS benefit with VMP was seen across prespecified patient subgroups (age ≥ 75 years, stage III myeloma, creatinine clearance < 60 mL/min). Sixty-three percent of VMP patients and 73% of MP patients had received subsequent therapy. Time to next therapy (median, 30.7 v 20.5 months; HR, 0.557; P < .001) was longer with VMP than with MP. Among patients who received subsequent therapies, survival from start of subsequent therapy was similar following VMP (median, 28.1 months) or MP (median, 26.8 months; HR, 0.914). Following VMP/MP, incidence proportions of hematologic malignancies (1%/1%) and solid tumors (5%/3%) and exposure-adjusted incidence rates (0.017/0.013 per patient-year) were similar and were consistent with background rates. Conclusion VMP resulted in a significant reduction in risk of death versus MP that was maintained after 5 years' follow-up and despite substantial use of novel-agent-based salvage therapies. There is no emerging safety signal for second primary malignancies following VMP.
Book Reviews
Authors: Rand Graham K. 
Published: December 2012

In Book Reviews, we review an extensive and diverse range of books. They cover theory and applications in operations research, statistics, management science, econometrics, mathematics, computers, and information systems. In addition, we include books in other fields that emphasize technical applications. The editor will be pleased to receive an email from those willing to review a book, with an indication of specific areas of interest. If you are aware of a specific book that you would like to review, or that you think should be reviewed, please contact the editor. The following books are reviewed in this issue of Interfaces, 42(6), November–December 2012: Not for Free: Revenue Strategies for a New World, Saul J. Berman; Queueing Networks: A Fundamental Approach, Richard J. Boucherie and Nico M. Van Dijk, eds.; Rational Decision Making, Franz Eisenführ, Martin Weber, and Thomas Langer; Trends in Multiple Criteria Decision Analysis, Salvatore Greco, Matthias Ehrgott, and José Rui Figueira, eds.; You're Next!, Terry Green; Multiple Criteria Decision Making: From Early History to the 21st Century, Murat Köksalan, Jyrki Wallenius, and Stanley Zionts; A Strategy for Using Multicriteria Analysis in Decision-Making: A Guide for Simple and Complex Environmental Projects, Nolberto Munier.
Implementation and Outcome Assessment of an Inpatient Antimicrobial Stewardship Program
Authors: Hagert Brandie L. , Williams Cristin , Wieser Catherine M. , Rohrich Melissa A. , Lo Tze Shien , Newman William P. , Koo Ji M. 
Published: December 2012

Background An antimicrobial stewardship program (ASP), aiming to optimize antimicrobial usage, was implemented at a Veterans Affairs Health Care System (VA HCS). Objective The main objective of this study was to compare antimicrobial usage before and after implementation of an ASP and to assess ASP interventions. Method This retrospective study was conducted at the Fargo VA HCS. A total of 1,017 inpatient charts were reviewed for 2 distinct time periods, February through September 2008 (pre ASP) and February through September 2010 (post ASP). The data that were collected and analyzed included the number of hospitalized patients prescribed antimicrobials, antimicrobial therapy duration, duration of hospital stay, and inpatient antimicrobial costs. Subgroup analyses were performed on the top 5 antimicrobials and the top 6 indications. The number, types of, and overall acceptance rate of ASP interventions were also assessed. Results When the pre- to post-ASP periods were compared, the percentage of patients on antimicrobial therapy decreased from 36.8% to 25% ( P < .001), the median duration of antimicrobial therapy significantly decreased ( P = .02), and the defined daily dose (DDD) per 1,000 patient bed days was reduced for piperacillin/tazobactam, vancomycin, and ciprofloxacin. In addition, the total inpatient antimicrobial costs decreased by $48,044 (25%). The overall ASP intervention acceptance rate was 81.6% (315 out of 386 total interventions). Conclusion The results of this study show that ASP implementation has been highly accepted by providers and has been associated with a reduction in the number of patients prescribed antimicrobials, median duration of antimicrobial therapy, and antimicrobial inpatient costs.
Severity of Infantile Nystagmus Syndrome-Like Ocular Motor Phenotype Is Linked to the Extent of the Underlying Optic Nerve Projection Defect in ZebrafishbelladonnaMutant
Authors: Huber-Reggi Sabina P. , Chen Chien-Cheng , Grimm Lea , Straumann Dominik , Neuhauss Stephan C. F. , Huang Melody Ying-Yu 
Published: December 2012

Infantile nystagmus syndrome (INS), formerly known as congenital nystagmus, is an ocular motor disorder in humans characterized by spontaneous eye oscillations (SOs) and, in several cases, reversed optokinetic response (OKR). Its etiology and pathomechanism is largely unknown, but misrouting of the optic nerve has been observed in some patients. Likewise, optic nerve misrouting, a reversed OKR and SOs with INS-like waveforms are observed in zebrafishbelladonna(bel) mutants. We aimed to investigate whether and how misrouting of the optic nerve correlates with the ocular motor behaviors inbellarvae.OKR and SOs were quantified and subsequently the optic nerve fibers were stained with fluorescent lipophilic dyes. Eye velocity during OKR was reduced in larvae with few misprojecting optic nerve fibers and reversed in larvae with a substantial fraction of misprojecting fibers. All larvae with reversed OKR also displayed SOs. A stronger reversed OKR correlated with more frequent SOs. Since we did not find a correlation between additional retinal defects and ocular motor behavior, we suggest that axon misrouting is in fact origin of INS in the zebrafish animal model. Depending on the ratio between misprojecting ipsilateral and correctly projecting contralateral fibers, the negative feedback loop normally regulating OKR can turn into a positive loop, resulting in an increase in retinal slip. Our data not only give new insights into the etiology of INS but may also be of interest for studies on how the brain deals with and adapts to conflicting inputs.
Unternehmensformen oder Formen von Unternehmungen zwischen Spätmittelalter und beginnender Früher Neuzeit
Authors: Rothmann Michael 
Published: December 2012

Abstract
The article “Business forms or types of companies between the late Middle Ages and the onset of the early modern” focuses on “entrepreneurial” activity on the one hand and on the business-like structures and networks of capital and labor-intensive large undertakings between 1300 and 1550 on the other. The first case study shows how intensively the domain was involved in the economy and markets already at this time through good planning and accounting, by taking the example of a noble estate in the 15th Century. The article then compares the operational and corporate organizational structures in the central European mining sector in the early 16th Century by means of a second case study. It shows that mining and metallurgy emerged early on in various corporate and operational forms, because of the capital requirements of large-scale production conditions, distance and the differentiated division of labor organization, but differed greatly from each other because of their strong adjustment in respective political and environmental conditions. Based on the “Corporate Governance” of the Italian banking houses of the 14th Century the third example explains how early the company’s size and distance relationships were able to mould the organizational structure of these financial institutions. With increasing international trade and credit transactions only the semantics of family and kinship survived. Overall, the article is able to show by means of its examples, that increasing company size, greater market orientation, an increasing need for capital, the internationalization of market relations and the question of the risk limit lead to the emergence of new institutional forms of business organization from the late Middle Ages onwards.
Vorindustrielle Unternehmer? Ökonomische Akteure und Betriebsformen im 18. und frühen 19. Jahrhundert
Authors: Gorißen Stefan 
Published: December 2012

Abstract
In recent economic history entrepreneurship seems to be a subject that is only dealt with in modern industrial societies, although the term is often used even in reference to medieval and early modern trading companies. Given this confusion in terminology this article proposes to define enterprise in terms of transaction costs-theory and to assess the building of enterprises as a process of vertical integration. In pre-industrial times this relates mostly the integration of production and distribution in a common entrepreneurial framework. In order to supply evidence in favour of this model the article looks at three protoindustrial production systems: wool production in the Aachen region; iron and steel processing trades in the duty of Berg; and the linen trades in Silesia.
Die Transformation von Märkten und die Entstehung moderner Unternehmen
Authors: Engel Alexander 
Published: December 2012

Abstract
According to institutional economics, transactions are carried out either in the market or within firms, with the latter emerging when market transactions become internalized. This suggests that the history of modern enterprises cannot be fully understood without investigating the history of markets as well. This paper makes some socioeconomic generalizations about the specific configuration of pre-modern markets and their transformation in the 19th century. When the focus shifted from a fairly invariable range of moderately processed commodities to a dynamic range of more highly processed, producerspecific specialties, it rendered the formerly useful separation of production and consumption by a sphere of independent all-purpose merchant ineffective, and fostered the combination of production, distribution, and functions relating to product innovation (R&D, marketing, legal protection). This necessitated the close coordination of specialists, prompting the rise of integrated organizations, whose success finalized the transformation of markets.
Zur Funktion der Aktiengesellschaften in der frühen Industrialisierung
Authors: Reckendrees Alfred 
Published: December 2012

Abstract
Based on a new dataset of Prussian joint stock companies founded before 1870 this article indicates that early German joint stock companies were concentrated in a few highly developed regions. After the region became Prussian in 1815 the Rhine Province with its favourable institutional environment due to the persistence of French law (Code de Commerce) hosted a very large part of the Prussian industrial joint stock companies. Qualitative analysis of early joint stock companies in the industrial district of Aachen shows that the new institution allowed for related diversification of industrial investments into new industries within the region and contributed to the regional diffusion of technology, management knowhow, and economic expertise.
Wrong opinions of Dead Men? On the relevance of the history of economic thought for modern economics – A plea for the history of economic thought
Authors: Pierenkemper Toni 
Published: December 2012

Abstract
Over the last 250 years economic thinking has undergone considerable changes. This article gives a brief overview of major developments and their respective representations within this scientific field. It then elaborates on the fact that the development of these different opinions – or approaches – is mainly due to changing historical circumstances. Economists try to solve contemporary problems; their aims, objects, and methods vary accordingly. However, this does not affect the relevance traditional approaches might have for modern economics. They can indeed prove to be very helpful in tackling today’s economic problems, if economists manage to adjust them to actual circumstances. Within the history of economic thought those traditional concepts are preserved and assembled to enable contemporary scientists to learn from the past.
“Secret Mechanism”: Les Contes d'Hoffmann and the Intermedial Uncanny in the Metropolitan Opera's Live in HD Series
Authors: Wells Brianna 
Published: December 2012

Abstract
The Metropolitan Opera's Live in HD series has sparked interdisciplinary interest in understanding opera in twenty-first-century contexts. This article posits that the Live in HD series creates an intermedial experience for its viewers, one that forms new relationships between operatic performance and audiences through the ongoing intersections of production elements (story, text, music, mise-en-scène, performers) and media-specific concerns (spectatorial gaze, hypermediacy, immediacy, reproducibility, liveness). A reading of act I from the 2009 Metropolitan Opera simulcast of Offenbach's Les Contes d'Hoffmann engages the shifting relations regarding the human and the technological as presented to the Live in HD viewer from the vantage point of on, back, beside, in front of, and yet completely discrete from the Lincoln Center stage.
The mediated and mediatized relationships engendered by this constant resituating of the audience create a sense of the familiar rendered strange, of being somehow out of place in one's relation to the stage. Media and performance theory are employed in concert with Freud's influential work on the uncanny to describe this as the “intermedial uncanny”: an important aspect of this emergent audience experience.
Atomic Scale Simulation of the Effect of Hydrogen on Dislocations in Zr
Authors: Domain C. , Legris A. 
Published: December 2012

AbstractIn nuclear power plants, Zr–based cladding is corroded by the primary coolant. Concomitantly, it undergoes hydrogen pick–up which induces modifications of its mechanical properties, especially creep and recrystallization rates. Below 600K, the deformation in hcp Zr is partially controlled by screw dislocations, which due to their intricate core structure have reduced intrinsic mobility. Here, we address the possible hydrogen induced modifications of the core structure of screw dislocations. We used first–principle calculations based on the density functional theory to evaluate the interaction between hydrogen and screw dislocation cores and also to evaluate the hydrogen induced modifications of the prismatic and basal gamma surfaces. We show that the presence of hydrogen results in significant reductions of the stacking fault energies.
Selection of Proppants for Long-Term Stability
Authors: Raysoni Neelam , Weaver Jim 
Published: December 2012

Abstract
Proppant is used to keep hydraulic fractures open and to maintain the conductivity of the fracture. This helps operators produce the well economically. It is normal for well productivity to decline as reservoir pressure declines. However, steeper rates of decline are often observed, which have been attributed to additional damage mechanisms, such as proppant crushing, embedment, and fines migration.
Proppant diagenesis may also be a contributing factor affecting production decline. Proppant diagenesis has been discussed previously (Weaver and Rickman 2010), where pressure solution and the compaction mechanisms are proposed to be responsible for causing diagenesis of proppant. This concept has gained momentum and has been the subject of other recent studies and discussions, particularly in the hydrothermal industry.
Choosing the correct proppant for a given formation at the reservoir temperature and stress becomes an important factor. Selection of proppant should not be based solely on the crush strength of the proppant at the applied stress value, but should also depend on the overall integrity of the proppant after being exposed to the reservoir conditions. Choosing the proper proppant for the job should be more economical for the long-term stability of the well.
This paper provides details of the testing protocols developed to provide improved understanding of proppant diagenesis under different reservoir conditions. The discussion should help operators understand the importance of the procedures used to obtain accurate results, as well as shed light on the process of selecting the correct proppant for long-term fracture stability.
3-D Modeling of Fracture Initiation From Perforated Non-Cemented Wellbore
Authors: Alekseenko O. P. , Potapenko D. I. , Cherny S. G. , Esipov D. V. , Kuranakov D. S. , Lapin V. N. 
Published: December 2012

Abstract
A 3D numerical model of fracture initiation from a perforated wellbore in linear elastic rock is developed, which allows one to determine the fracture initiation pressure (FIP) and the location and direction of an initial rupture. The model assumes that the fracture initiates at the point where the local maximum tensile stress exceeds the rock tensile strength. The 3D boundary element method is used for stress analysis.
The model is aiming at predicting the location of initial fractures and the difference in FIP between different perforation intervals in arbitrarily oriented non-cemented wellbores. There are many practical applications where this knowledge is required, but of particular interest for this research is the employment of differently oriented perforations for creating heterogeneity of FIP between wellbore intervals in multistage fracturing treatment. This can enable stimulation of these intervals in a sequential mode and significantly simplify current treatment diversion and completion practices.
Comprehensive analysis revealed that the main parameter that can be used for controlling FIP during multistage fracturing treatment is the angle between the direction of the perforation channel and the preferred fracture plane. The model allows obtaining the range of the angles that is the most suitable for designing and implementation of diversion between the perforated wellbore intervals. The influence of geometrical parameters of perforation (e.g. length, diameter and shape) on FIP is substantially less. Addtionally we found that against all expectations increase of perforation diameter can result in higher FIP. It was also discovered that the influence of the intermediate in-situ stress on FIP is comparable with the effect of perforation misalignment especially in the situation of horizontal wellbore and properly aligned perforations. Based on the model developed, an approximate approach to the evaluation of the impact of wellbore cementation on fracture initiation was suggested. It was discovered that taking into account the state of stress within the cement prior to well pressurization can result in both an increase and reduction of FIP depending on the parameters of perforating as well as wellbore orientation.
The presented model is the necessary step toward predictable and controllable fracture initiation, which is vital for multistage fracturing treatment diversion.