bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐efficiency dual‐input converter with high‐voltage gain and internal charge function
Authors: Wai Rong‐Jong , Hong Lian‐Sheng 
Published: August 2013

In this study, a high‐efficiency dual‐input converter with an internal charge circuit is developed. The proposed coupled‐inductor‐based converter can boost the voltages of two input power sources with different low‐voltage levels to a controllable high‐voltage DC bus. The high‐voltage DC bus can be taken as the main power for a high‐voltage DC load or the front terminal of a DC–AC inverter. The charge circuit inside the proposed dual‐input converter can provide the redundant energy from the major source for the auxiliary power source (e.g. battery module) to save the manufacturing cost. According to the operation of power management, the operational states of the proposed dual‐input converter can be divided into three situations including a standalone power‐supply state, a charge state and a unify power‐supply state. The techniques of voltage clamping and soft switching are employed in this converter, and the corresponding device specifications are adequately performed. Thus, the goal of high‐efficiency dual‐input power conversion with high‐voltage gain can be achieved. Some experimental results via a 1.5 kW‐level prototype are given to verify the effectiveness of the proposed dual‐input converter in practical applications.
fmcsR: mismatch tolerant maximum common substructure searching in R
Authors: Wang Yan , Backman Tyler W. H. , Horan Kevin , Girke Thomas 
Published: August 2013

Abstract
Motivation: The ability to accurately measure structural similarities among small molecules is important for many analysis routines in drug discovery and chemical genomics. Algorithms used for this purpose include fragment-based fingerprint and graph-based maximum common substructure (MCS) methods. MCS approaches provide one of the most accurate similarity measures. However, their rigid matching policies limit them to the identification of perfect MCSs. To eliminate this restriction, we introduce a new mismatch tolerant search method for identifying flexible MCSs (FMCSs) containing a user-definable number of atom and/or bond mismatches.
Results: The fmcsR package provides an R interface, with the time-consuming steps of the FMCS algorithm implemented in C++. It includes utilities for pairwise compound comparisons, structure similarity searching, clustering and visualization of MCSs. In comparison with an existing MCS tool, fmcsR shows better time performance over a wide range of compound sizes. When mismatching of atoms or bonds is turned on, the compute times increase as expected, and the resulting FMCSs are often substantially larger than their strict MCS counterparts. Based on extensive virtual screening (VS) tests, the flexible matching feature enhances the enrichment of active structures at the top of MCS-based similarity search results. With respect to overall and early enrichment performance, FMCS outperforms most of the seven other VS methods considered in these tests.
Availability: fmcsR is freely available for all common operating systems from the Bioconductor site (http://www.bioconductor.org/packages/devel/bioc/html/fmcsR.html).
Contact: thomas.girke@ucr.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Public perceptions of wetland restoration benefits in Louisiana
Authors: Kim Tae-Goun , Petrolia Daniel R. 
Published: August 2013

AbstractKim, T-G., and Petrolia, D. R. 2013. Public perceptions of wetland restoration benefits in Louisiana. – ICES Journal of Marine Science, 70: 1045–1054. We conducted a referendum-style contingent-valuation survey to investigate public perceptions of wetland restoration benefits including storm protection, ecosystem services, and recreational benefits and to analyse willingness to pay (WTP) for large-scale coastal restoration in Louisiana. Results of the ordered probit and binary probit models indicate that the public perceives both a strong relationship between increased wetland loss and an increased storm risk and a substantial likelihood of increased storm-protection benefits from wetland restoration. However, respondents expressed that they were less likely to believe the improved storm reduction benefits from restoration when they perceived a high frequency of category 3 or greater storms. Additionally, we found that hurricane protection benefits were the most important factor explaining WTP for wetland restoration for preventing expected future land losses in coastal Louisiana.
Overconfidence in model projections
Authors: Brander Keith , Neuheimer Anna , Andersen Ken Haste , Hartvig Martin 
Published: August 2013

Abstract
Brander, K., Neuheimer, A., Andersen, K. H., and Hartvig, M. 2013. Overconfidence in model projections. – ICES Journal of Marine Science, 70: 1065–1068. There is considerable public and political interest in the state of marine ecosystems and fisheries, but the reliability of some recent projections has been called into question. New information about declining fish stocks, loss of biodiversity, climate impacts, and management failure is frequently reported in the major news media, based on publications in prominent scientific journals. Public and political awareness of the generally negative changes taking place in marine ecosystems is welcome, especially if it results in effective remedial action, but the scientific basis for such action must be reliable and uncertainties arising from models and data shortcomings must be presented fully and transparently. Scientific journals play an important role and should require more detailed analysis and presentation of uncertainties.
How to make progress in projecting climate change impacts
Authors: Cheung William W. L. , Pauly Daniel , Sarmiento Jorge L. 
Published: August 2013

Abstract
Cheung, W. W. L., Pauly, D., and Sarmiento, J. L. 2013. How to make progress in projecting climate change impacts. – ICES Journal of Marine Science, 70: 1069–1074. Scientific modelling has become a crucial tool for assessing climate change impacts on marine resources. Brander et al. criticize the treatment of reliability and uncertainty of such models, with specific reference to Cheung et al. (2013, Nature Climate Change, 3: 254–258) and their projections of a decrease in maximum body size of marine fish under climate change. Here, we use the specific criticisms of Brander et al. (2013, ICES Journal of Marine Science) on Cheung et al. (2013) as examples to discuss ways to make progress in scientific modelling in marine science. We address the technical criticisms by Brander et al., then their more general comments on uncertainty. The growth of fish is controlled and limited by oxygen, as documented in a vast body of peer-reviewed literature that elaborates on a robust theory based on abundant data. The results from Cheung et al. were obtained using published, reproducible and peer-reviewed methods, and the results agree with the empirical data; the key assumptions and uncertainties of the analysis were stated. These findings can serve as a step towards improving our understanding of climate change impacts on marine ecosystems. We suggest that, as in other fields of science, it is important to develop incrementally (or radically) new approaches and analyses that extend, and ultimately improve, our understanding and projections of climate change effects on marine ecosystems.
Effect of Molecular Adsorbents Recirculating System Treatment in Children With Acute Liver Failure Caused by Wilson Disease
Authors: Rustom Najla , Bost Muriel , Cour‐Andlauer Fleur , Lachaux Alain , Brunet Anne‐Sophie , Boillot Olivier , Bordet Fabienne , Valla Frederic , Richard Nathalie , Javouhey Etienne 
Published: August 2013

ABSTRACTObjectives:Because fulminant Wilson disease (WD) has an extremely poor prognosis, the use of liver support that can bridge patients to liver transplantation is lifesaving. We report the experience of albumin dialysis in acute liver failure (ALF) caused by WD in children.Methods:Chart review of children admitted for ALF secondary to acute WD and treated by the molecular adsorbents and recirculating system. Measures of copper level in blood and within the circuit during molecular adsorbents recirculating system (MARS) sessions were performed. Clinical and biological assessments after MARS session were reported.Results:Four children, with a median age of 12.3 years, were treated from 2004 to 2009 for a severe ALF associated with acute renal failure, haemolysis, and severe cholestasis. All of the children had a new Wilson index >12. A total of 14 MARS sessions were performed, for a median duration of 7.5 hours. Tolerance was good, except for 1 child who experienced haemorrhage because of vascular injury following insertion of the dialysis catheter. A neurological improvement or stabilisation was noted in all of the children along with an improvement in the Fisher index and ammonia level after MARS treatment. MARS was able to remove copper, to decrease the serum copper level of 28% in mean, and to decrease the bilirubin and creatinin levels >25%. All of the children were subsequently underwent liver transplants with a good outcome without disability.Conclusions:MARS is able to remove copper and to stabilise children with ALF secondary to WD, allowing bridging to LT.
Enteric Neural Disruption in Necrotizing Enterocolitis Occurs in Association With Myenteric Glial Cell CCL20 Expression
Authors: Fagbemi Andrew O. , Torrente Franco , Puleston Joanne , Lakhoo Kokila , James Sean , Murch Simon H. 
Published: August 2013

ABSTRACTObjective:The aetiology of necrotising enterocolitis (NEC) is unknown, but luminal factors and epithelial leakiness appear critical triggers of an inflammatory cascade. A separate finding has been suggested in mouse models, in which disruption of glial cells in the myenteric plexus induced a severe NEC‐like lesion. We have thus looked for evidence of neuroglial abnormality in NEC.Methods:We studied full‐thickness resected specimens from 20 preterm infants with acute NEC and from 13 control infants undergoing resection for other indications. Immunohistochemical analysis was performed for immunological (CD3, syndecan‐1, human leucocyte antigen‐DR), neural (glial fibrillary acidic protein [GFAP], nerve growth factor receptor, neurofilament protein, neuron‐specific enolase), and functional markers (Ki67), and for potential inflammatory regulators (interleukin‐12, transforming growth factor‐β, CCL20, CCR6).Results:Expression of the chemokine CCL20 and its receptor CCR6 was significantly upregulated in myenteric plexus in NEC, with CCL20 strongly expressed by glial cells. In 9 of 20 cases with NEC, myenteric plexus architecture and GFAP+ glial cells were normal, with preserved submucosal and mucosal innervation; however, 11 cases showed disrupted myenteric plexus architecture, reduced GFAP expression, and loss of submucosal and mucosal innervation. Persistent abnormalities were identified in the 2 infants who had ongoing inflammation at ileostomy closure.Conclusions:Our findings identified heterogeneity among patients with NEC. Approximately half showed evidence of marked neural abnormality extending from the deeper layers of the intestine, associated with glial activation and myenteric plexus disruption. The factors that may activate enteric glia in this manner, potentially including bacterial products or viruses, remain to be determined.
Exome Sequencing Finds a Novel PCSK1 Mutation in a Child With Generalized Malabsorptive Diarrhea and Diabetes Insipidus
Authors: Yourshaw Michael , Solorzano‐Vargas R. Sergio , Pickett Lindsay A. , Lindberg Iris , Wang Jiafang , Cortina Galen , Pawlikowska‐Haddal Anna , Baron Howard , Venick Robert S. , Nelson Stanley F. , Martín Martín G. 
Published: August 2013

ABSTRACTObjectives:Congenital diarrhea disorders are a group of genetically diverse and typically autosomal recessive disorders that have yet to be well characterized phenotypically or molecularly. Diagnostic assessments are generally limited to nutritional challenges and histologic evaluation, and many subjects eventually require a prolonged course of intravenous nutrition. Here we describe next‐generation sequencing techniques to investigate a child with perplexing congenital malabsorptive diarrhea and other presumably unrelated clinical problems; this method provides an alternative approach to molecular diagnosis.Methods:We screened the diploid genome of an affected individual, using exome sequencing, for uncommon variants that have observed protein‐coding consequences. We assessed the functional activity of the mutant protein, as well as its lack of expression using immunohistochemistry.Results:Among several rare variants detected was a homozygous nonsense mutation in the catalytic domain of the proprotein convertase subtilisin/kexin type 1 gene. The mutation abolishes prohormone convertase 1/3 endoprotease activity as well as expression in the intestine. These primary genetic findings prompted a careful endocrine reevaluation of the child at 4.5 years of age, and multiple significant problems were subsequently identified consistent with the known phenotypic consequences of proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations. Based on the molecular diagnosis, alternate medical and dietary management was implemented for diabetes insipidus, polyphagia, and micropenis.Conclusions:Whole‐exome sequencing provides a powerful diagnostic tool to clinicians managing rare genetic disorders with multiple perplexing clinical manifestations.
Developing your organization with models and simulations
Authors: Mayfield Jacqueline , Mayfield Milton 
Published: August 2013

PurposeThis paper discusses how simulations can be used to improve organizations.Design/methodology/approachThe paper provides an overview of three major simulation methods – Petri nets, system dynamics, and agent based modeling.FindingsThe overview shows that while each method has different complexity levels and more appropriate areas for implementation, all can be used better understand organizational processes.Originality/valueThis paper provides a unique comparison of simulation methods in a developmental context.
Intercultural awareness and the global economy: Chinese students and academic literacy – a lesson larger than just paraphrasing
Authors: Henderson PhD Fiona , Whitelaw PhD Paul A. 
Published: August 2013

PurposeThe purpose of this paper is to evaluate a suite of academic literacy multimedia materials for Chinese students and reflect on educational approaches for the workplace.Design/methodology/approachThe literature review informed the initial resources which were trialled with volunteer groups of Chinese students in both Australia and China. A series of focus groups, follow up interviews and a workshop formed the basis of this qualitative studyFindingsAcademic literacy is one of the graduate attributes which students should obtain through their studies. Another area which demands student and employer attention in a globalised world is intercultural skills. It was found that students' engagement with interdisciplinary generic skills is lacking, sometimes due to the mostly textual way universities attempt to communicate with students about these skills. The multilayered, multimedia approach was successful; it is inclusive and sustainable for higher education and the workplace. A cross‐cultural understanding of academic literacy should enhance graduates' employability.Practical implicationsThe resources developed and assessed can be employed to enhance the transition of non‐Western students into the western higher education classroom and workplace.Originality/valueThe project advances existing national and international knowledge particularly with regards to teaching academic literacy to international students in Australia and the use of multimedia tools to assist understanding of key concepts and adoption of appropriate behaviours. Therefore, the use of a similar approach is suggested for business settings particularly for new graduate employees' learning of intercultural skills.
Embedding leadership throughout your organization
Authors: by Gareth Bell Interview 
Published: August 2013

PurposeThe aim is to provide an interview with Harshvendra Soin, VP Leadership Acquisition and Development, Tech MahindraDesign/methodology/approachInterviews Soin about Tech Mahindra's Young CEO programFindingsThe paper discusses the intended outcomes of the program.Practical implicationsThe paper outlines the company's desire to distribute leadership throughout the organization, by nurturing existing high‐potential employees.Originality/valueThe paper presents the insights of a leading practitioner in the field learning and development
Digital preservation policy in National Information Centres in Nigeria
Authors: Shiloba Gbaje Ezra , Mohammed Zakari 
Published: August 2013

PurposeThe study aims to examine availability, coverage of digital preservation policy and the structures put in place by National Information Centres in Nigeria to preserve digital information.Design/methodology/approachA qualitative research methodology using a case study approach was adopted. Documentary sources, a semi‐structured questionnaire for the focus group, and interviews were the instruments used to collect data. While a homogeneous sampling of five staff in the digitisation/digital preservation unit was adopted for the focus group interview, only one top management staff member from the rank of Assistant Director of each of the selected three National Information Centres was interviewed.FindingsThe National Bureau of Statistics and the National Library of Nigeria have digital preservation policies. However, the area of coverage of the available policies is not adequate enough to ensure the long‐term preservation of digital information. Similarly, the study revealed that the lack of institutional support from the National Information Centres studied is one of the challenges in the implementation of the digital preservation policy.Practical implicationsFor any National Information Centre to ensure the accessibility and reuse of its digital information, it must have a digital preservation policy, without which the active management of digital information will be very challenging and can result in the loss of vital digital information of significant importance.Originality/valueThere is currently no research work addressing issues on digital preservation policy with a particular focus on Nigeria. This paper therefore highlights shortcomings of the available digital preservation policy and proposes a national digital preservation policy that will chart a road map for effective digital preservation activities in any National Information Centre.
Library automation to resource discovery: a review of emerging challenges
Authors: Balaji Babu Preedip , Krishnamurthy M. 
Published: August 2013

PurposeThe purpose of this paper is to analyse the paradigm shift of library automation to resource discovery by exploring the applications of resource discovery. The present status of India on adapting resource discovery applications is discussed.Design/methodology/approachAn evaluative method to examine the status quo of India automation and resource discovery scenario is drawn with a related literature review. Moreover, various pertinent global challenges of embracing discovery tools in the digital environment are highlighted.FindingsThe growth of the Indian library automation industry is booming. However, library software adaptation, next‐generation catalogue enhancements and community development avenues are dearth, seemingly remote and far from satisfactory.Originality/valueThe paper focuses on the emerging scenario of resource discovery applications with an overview of global challenges.
Green supplier selection based on IFS and GRA
Authors: Bali Ozkan , Kose Erkan , Gumus Serkan 
Published: August 2013

PurposeGreen supply chain management (GSCM) has become an important issue with increasing awareness of environmental protection. A firm's environmental approach is not only relevant to its inner efforts, but its suppliers' environmental performance is also important. The aim of this study is to propose an integrated multi‐criteria decision‐making (MCDM) approach based on intuitionistic fuzzy set (IFS) and grey relational analysis (GRA) for green supplier selection.Design/methodology/approachGreen supplier selection is a MCDM process that contains different kinds of uncertainties. Because of the vagueness and imprecision of decision makers' evaluations and subjectivity of the criteria, IFS and GRA are exploited to handle these uncertainties.FindingsA numerical example is presented for the proposed approach. The analyses of the results show that fuzzy set theory and grey theory can be used jointly for green supplier selection problems in uncertain environments.Originality/valueThere are different kinds of uncertainties in the supplier selection process. The novelty of this study is to use proper uncertainty methods in different steps instead of denoting the whole selection process by the same uncertainty theory. Supplier selection problems occupy wide space in operations research literature. Different criteria are used in different papers. In this study, detailed literature review has been carried out and some criteria among frequently confronted ones proposed for green supplier selection.
Research on grey function analysis model (1,1) based on regional economy impact analysis
Authors: Wang Qunfeng , Fang Zhigeng , Guo Yuqiang , Yuan Chaoqing , Liu Hongqi , Xu Ruiting 
Published: August 2013

PurposeThe purpose of this paper is to realize scientific reasoning and prediction in economic catastrophe, which occurs in the short‐term and leads to invalidation of most classical prediction models through lacking basic sample data.Design/methodology/approachBased on functional theory, grey number algebra theory, Bayesian network theory and interval grey number theory, the authors established GFAM (1,1), which is grey function analysis model (1,1), to excavate and utilize the existing data sufficiently.FindingsThis paper proved least squares parameters theorem and prediction theorem and the process of GFAM (1,1). A case was established and demonstrated the utility and good prediction of this model.Originality/valueThis paper established GFAM (1,1), which overcomes the hysteretic defect of classical prediction model and provides a preferable solution in system prediction in economic catastrophe.