bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loneliness Predicts Suffering in Advanced Cancer Patients
Authors: Rendon Ana Maria Higuita , Medina Angela Medina , Gonzalez Carolina Palacio , Gomez John Jairo Vargas , Limonero Joaquin , Daveloza Alicia Krikorian 
Published: July 2024

Abstract

Objective: To determine the relationship between suffering, loneliness, social interaction, and symptom distress in patients with advanced cancer.
Methodology: Quantitative, observational, analytical cross-sectional study. Patients with advanced cancer attending a Pain and Palliative Care unit of an oncology institution participated. Assessment instruments included PRISM (suffering), the UCLA Loneliness Scale, the Edmonton Symptom Assessment Questionnaire, and Cohen´s Social Network Index (SNI). Univariate, bivariate, and multiple regression analyses were performed.
Results: One-hundred forty-four patients participated, mostly women (68.1 %), with a median age of 62 years, and 48.6% lived with a partner. About 75% reported moderate to severe suffering, 33% had clinically significant loneliness, and half reported a network width of at least eight people. ESAS showed fatigue as the most common problem and well-being had a median score of 5; In general, a low symptomatic burden was found. Suffering was significantly correlated with loneliness, pain, fatigue, depression, and anxiety, but not with levels of social interaction. According to the multiple regression analysis, loneliness has a positive and significant influence on the increase in suffering.
Conclusions: A high percentage of patients show significant suffering and almost a third show clinical levels of loneliness, which contrasts with a relatively large social network with frequent interactions, and a generally low symptomatic burden. The most single important predictor of suffering was loneliness. Our study points to the need to regularly assess these feelings and address them in treatment to lessen suffering. Future studies should delve deeper into the relationship between suffering and loneliness.
SLC34 mutation: Personal experience with six families and literature review
Authors: Bennani Hamza Naciri , Chtioui Imane , Allirot Camille , Somrani Rim , Jouve Thomas , Bourdat-Michel Guylhene , ROSTAING Lionel 
Published: July 2024

Abstract

Background
Mutations in SLC34A1 and SLC34A2 genes, which encode co-transporters NaPi2a and NaPi2c, respectively, can lead hypophosphatemia due to renal phosphate loss. This condition results in hypercalcitriolemia and hypercalciuria, leading formation of kidney stones and nephrocalcinosis. Phenotype is highly variable. Management include hyperhydration, dietary modifications, and/or phosphate supplementation. Thiazides and azoles may be used, but randomized studies are needed to confirm their clinical efficacy.
Methods
We conducted a retrospective study in pediatric nephrology unit at Grenoble University Hospital from January 2010 to December 2023. Study aimed to describe clinical and biological symptoms of patients with confirmed SLC34A1 and SLC34A3 gene mutations and their outcomes.
Results
A total of 11 patients (9 females) from 6 different families had mutations in the SLC34A1 (5 patients) and SLC34A3 (6 patients) genes. Median age at diagnosis was 72 [1-108] months. Average follow-up duration was 8.1 ± 4.5 years. Presenting symptom was nephrocalcinosis (4 cases), followed by renal colic (3 cases). At diagnosis, 90% of patients had hypercalciuria and 45% had hypercalcitriolemia. Management included hyperhydration and dietary advice. All patients showed favorable outcomes with normal growth and school attendance. One patient with an SLC34A3 mutation showed regression of nephrocalcinosis. Renal function remained normal.
Conclusion
Clinical and biological manifestations of SLC34 gene mutations are highly variable, even among siblings; therefore, management must be personalized. Hygienic-dietary measures (such as hyperhydration, a low sodium diet, and age-appropriate calcium intake) result in favorable outcomes in most cases. Use of azoles (e.g., fluconazole) appears to be a promising therapeutic option.
Radiotherapy for Refractory, Corticosteroid-Resistant Orbital Inflammatory Diseases: Plan Design, Clinical Efficacy, and Prognosis/Outcomes
Authors: Ma Yan , Chen Haiyang , Huang Fujing , Pang Xiaolin , Zheng Jian , He Fang 
Published: July 2024

Abstract

Purpose
Orbital inflammatory diseases (OID), including Graves’ ophthalmopathy (GO), orbital pseudotumor (OP), and IgG4-related ophthalmic disease (IgG4-ROD), often require prolonged corticosteroid therapy, which may lead to severe hormonal side effects. These diseases are notably refractory and resistant to corticosteroids. While opposing lateral-field radiotherapy has shown positive results, the potential of volumetric-modulated arc therapy (VMAT) to enhance efficacy and reduce side effects remains uncertain. This study evaluates the radiation dose, clinical efficacy, side effects, and outcomes of orbital VMAT in patients with refractory, corticosteroid-resistant OID.
Methods and materials:
A retrospective analysis was conducted on 58 patients with refractory, corticosteroid-resistant OID treated with orbital VMAT from November 2019 to July 2022. The primary endpoint was the reduction or cessation of corticosteroid use following radiotherapy, with secondary endpoints including improvements in ocular clinical symptoms (diplopia, proptosis, visual acuity, and extraocular movement) and long-term side effects.
Results
The median target dose was 20 Gy, with an average lens irradiation dose of 5.4 Gy. Initially, all 58 patients received corticosteroids. After a median follow-up of 27.5 months, 89.7% (52/58) of patients responded positively to radiotherapy: specifically, 55.2% (32/58) completely tapered off corticosteroids, while 34.5% (20/58) reduced their dosage. Symptomatic improvements were observed in diplopia (66.0%), proptosis (63.5%), visual acuity (55.2%), and extraocular movements (66.7%). Regarding the long-term side effects of radiotherapy, incidences of dry eye syndrome and lens opacities were reported at 3.4% and 1.7%, respectively.
Conclusions
Orbital VMAT is an effective treatment for refractory, corticosteroid-resistant OID, reducing corticosteroid use and improving ocular symptoms with minimal side effects. Further prospective clinical trials are warranted to validate more appropriate VMAT doses and planning models, enhancing treatment outcomes without increasing radiotherapy side effects.
Tilt and self-potential observations of Kibedani Geyser, Japan: Relationship between fluid flow and CO2-driven geyser activity
Authors: Tanabe Harutou , Aizawa Koki , Matsushima Takeshi 
Published: July 2024

Abstract

Multi-parameter, multi-site observations were undertaken at the Kibedani Geyser, Japan, where the eruption of cold spring-water (20℃) is driven by underground CO2 pressure. Video, temperature, self-potential (SP), ground tilt, and acoustic observations were undertaken. Tilt and SP data display temporal changes related to the geyser cycle of 38 min (32 min between eruptions, with 6 min of eruption). Tilt data indicate that an inclined crack-shaped cavity pressure source expands between eruptions and contracts during eruption, with post-eruption re-expansion beginning ~2.5 min after eruption, when ground tremor has ceased. SP changes suggest groundwater inflow to the pressure source. We conclude that CO2 accumulates in the cavity, uplifting water for eruption. Tilt and SP multi-site observations were effective in estimating fluid flows associated with geyser activity.
Nuclear magnetic resonance spectroscopy based investigation of placenta and serum metabolic signatures in an L-NAME-induced preeclampsia rat model
Authors: Xu Xiaomin , Gao Lidan , Sun Congcong , Li Xiaoqing , Li Yanjun , Wang Wenhuan , Yang Xiaokai , Zheng Yanyan 
Published: July 2024

Abstract

Introduction
Despite numerous studies investigating potential metabolic biomarkers of preeclampsia (PE), there remains a dearth of comprehensive animal model validation to ascertain the utility of these metabolic markers as predictors for PE risk.
Objective
To characterize the serum and placental metabolome profiles in a N-nitro-L-arginine methyl ester (L-NAME) induced PE rat model, and identify potential differential metabolites to improve disease classification based on existing diagnostic markers.
Methods
The serological indicators and uterine artery blood flow indexes were measured in L-NAME-induced early-onset PE (EOPE) and late-onset PE (LOPE) rat models. Untargeted proton nuclear magnetic resonance metabolomics analysis was employed to compare serum and placenta tissue extracts, aiming to identify distinguishing metabolites. The random forest decision tree algorithm was utilized for validating biomarker metabolites and establishing classification models.
Results
Several characteristic metabolites associated with the development of preeclampsia in humans can be validated using L-name-induced PE as a model. EOPE and lope exhibit distinct and overlapping metabolic signatures, indicating unique and shared pathways. A combination of two serum metabolites (aspartate/ tryptophan/ 3-hydroxybutyrate) could effectively discriminate between different groups. Moreover, the classification accuracy of placental metabolites (creatine/acetate) combined with serum tryptophan surpasses that of existing serum markers and uterine artery blood flow indexes.
Conclusion
The identification of serum and placental metabolites holds potential to augment the classification accuracy of existing biomarkers. Nevertheless, comprehensive validation of metabolic markers necessitates further support from additional PE animal models.
The short-term clinical outcomes of endoscopic rubber band ligation for grade I~III internal hemorrhoids
Authors: Xu Shanshan , Li Zhenjuan , Ding Hui , Zhang Hao , Li Xiuling 
Published: July 2024

Abstract

Background To investigate the short-term safety and efficacy of endoscopic rubber band ligation (ERBL) for grade I~III internal hemorrhoids, and to analyze the related factors of adverse events after ERBL.
Methods The clinical data of 266 patients with grade I~III internal hemorrhoids treated by ERBL in Henan Provincial People's Hospital from January 2021 to June 2023 were retrospectively analyzed. According to the Goligher’s grading of internal hemorrhoids, the patients were divided into three groups: grade I (98 patients), grade II (56 patients) and grade III internal hemorrhoids (112 patients). The clinical efficacy and adverse events (AEs) 24h after ERBL of the three groups were compared and analyzed.
Results The effectiveness rate of grade I, II and III internal hemorrhoids were 88.8%, 87.5% and 86.6%, respectively, with no statistical difference (p>0.05). A total of 107 (40.2%) patients had AEs 24h after ERBL, of which 11 (4.1%) had postoperative bleeding, 48 (18.0%) had anal pain, 80 (30.1%) had sense of anal sagging, and 15 (5.6%) had urinary retention. The postoperative adverse events of grade I, II and III internal hemorrhoids were 42.9% (42/98), 51.8% (29/ 56) and 32.1% (36/112), respectively, and the difference was statistically significant (p<0.05). Univariate and multivariate analysis showed that the suspension ligation was the protective factor for postoperative AEs [OR (95%CI): 9.64 (2.124,43.79), p=0.04].
Conclusions ERBL is effective for grade I~III internal hemorrhoids, but it is safer for grade III internal hemorrhoids. Suspension ligation can reduce postoperative adverse reactions. Multicenter, prospective studies are needed to verify our conclusion.
Investigation of psychological distress and sleep quality in hematopoietic stem cell transplantation patients: a cross-sectional study
Authors: Wu Qian , Xu Jing , Huang Jing , Chen Lin , Zhang Yongjia , Zhang Yuan , Wang Tiehao 
Published: July 2024

Abstract

Objective
The aim of this study was to investigate the current status and correlation between psychological distress and sleep quality in hematopoietic stem cell transplantation, and to identify risk factors affecting psychological distress and sleep quality in patients.
Methods
This study investigated 275 patients who underwent hematopoietic stem cell transplantation in the laminar flow research unit of West China Hospital of Sichuan University. Surveys were conducted after they underwent transplantation, including demographic characteristics, the West China Heart Clearance Index score, and the Pittsburgh Sleep Quality Index.
Results
Anxiety and depression were present in 106 of the 275 patients. 198 patients had sleep disturbances. Sleep quality was significantly associated with anxiety and depression. Length of hospitalization, transplant complications and sleep disorders were risk factors for anxiety and depression. Transplant complications and anxiety and depression were risk factors for sleep disorders.
Conclusion
Hematopoietic stem cell transplant patients commonly experience anxiety, depression, and sleep disturbances during hospitalization. Early assessment and intervention can improve patient prognosis and quality of life in the mid- and long-term.
Single specimen genome assembly of Culicoides stellifer shows evidence of a non-retroviral endogenous viral element
Authors: Castellanos-Labarcena Jessica , Milián-García Yoamel , Elliott Tyler A. , Steinke Dirk , Hanner Robert , Adamowicz Sarah J. 
Published: July 2024

Abstract

Background Advancing our knowledge of vector species genomes is a key step in our battle against the spread of diseases. Biting midges of the genus Culicoides are vectors of arboviruses that significantly affect livestock worldwide. Culicoides stellifer is a suspected vector with a wide range distribution in North America, for which cryptic diversity has been described.Results With just one specimen of C. stellifer, we assembled and annotated both a high-quality nuclear and a mitochondrial genome using the ultra-low input DNA PacBio protocol. The genome assembly is 119 Mb in length with a contig N50 value of 479.3 kb, contains 11% repeat sequences and 18,895 annotated protein-coding genes. To further elucidate the role of this species as a vector, we provide genomic evidence of a non-retroviral endogenous viral element integrated into the genome that corresponds to rhabdovirus nucleocapsid proteins, the same family as the Vesicular Stomatitis Virus.Conclusions This genomic information will pave the way for future investigations into this species's putative vector role. We also demonstrate the practicability of completing genomic studies in small dipterans using single specimens preserved in ethanol as well as introduce a workflow for data analysis that considers the challenges of insect genome assembly.
Treatment options for traumatic abducens nerve injury: a dual-center clinical experience
Authors: Hou Xiaofei , Hu Guancheng , Fu Hua , Yang ShengWei 
Published: July 2024

Abstract

Objective: This study aimed to assess the therapeutic efficacy of surgical and conservative treatments in patients with traumatic abducens nerve injury on neurofunctional recovery based on dual-center clinical experience.
Methods: A retrospective analysis was conducted on the clinical data of 71 patients with traumatic abducens nerve injury. Patients were categorized into the operation group and the conservative treatment group based on whether patients underwent surgical intervention during their hospitalization. A comparison was made between the two groups regarding ocular motility recovery before and after treatment. In addition, patients were further divided into complete paralysis and incomplete paralysis groups based on their initial ocular position score for subgroup analysis.
Results: The overall effective rate of conservative treatment group was 81.82%, while the overall effective rate of operation group was 88.89%. there is no statistically significant difference (χ2=0.173, P=0.678) between two groups. Subgroup analysis indicated that both in the conservative treatment group and in the surgical group, the efficacy rate is significantly lower in the complete paralysis subgroup compared to the incomplete paralysis subgroup. Results showed the total effective rate was 92.31% vs .66.67%（χ2=4.70, P<0.05） on conservative treatment group and 100% vs .66.67% （χ2=3.857, P<0.05）on operation group.
Conclusion: The total effectiveness rate of the conservative treatment group was similar to that of the operation group, suggesting no difference in treatment effectiveness between two treatment plans, and the prognosis of traumatic abducens nerve injuries remains favorable. However, the higher the initial ocular position score of the patient, the more severe the paralysis symptoms, and the worse the treatment effect. Thus, treatment choices should be individualized to ensure optimal results.
Teachers' Perception of Artificial Intelligence Integration in Learning: A Cross-Sectional Online Questionnaire Survey
Authors: Prasetya Yovian Yustiko , Reba Yansen Alberth , Muttaqin M.Zaenul , Susongko Purwo , Sudibyo Hanung , Taufiqulloh Taufiqulloh 
Published: July 2024

Abstract

This study aimed to analyze the influence of teaching experience and age on teachers' perceptions of AI integration in learning. The study involved 108 junior and senior high school teachers from Papua and Central Java, using quantitative methods with one-way ANOVA analysis. The results showed significant differences in teachers' perceptions based on teaching experience (F(2, 105) = 3.2154, p = 0.0441), with experienced teachers > 10 years having more positive perceptions than experienced teachers < 5 years. In contrast, no significant difference was found based on age (F(2, 105) = 2.0124, p = 0.1386). This finding suggests that AI training programs need to consider the level of teaching experience, but do not need to differentiate by age. In conclusion, teaching experience plays an important role in shaping teachers' perceptions of AI integration, while age has no significant influence. This study provides valuable insights for the development of teacher training programs that are effective in integrating AI into learning.
An UPLC method for determination of structural analogues of DM1, the payload of trastuzumab emtansine (T-DM1)
Authors: Yao Junliang 
Published: July 2024

Abstract

DM1, a derivative of maytansine, is the payload of trastuzumab emtansine (T-DM1). In this work, a new gradient reverse-phase ultra-performance chromatographic (RP-UPLC) method was proposed for analysis of five structural analogues (DM1-2, AP-3, DM1-4D, DM1-3D, DM1-3L) of DM1. The chromatographic separation was accomplished by using a Waters BEH Phenyl column (50 × 2.1 mm, 1.7 µm), at the wavelength of 252 nm. Validation of the method was carried out according the ICH guidelines in terms of specificity, accuracy, precision, linearity and robustness. The developed method was proved to be convenient and reliable for quantitative determination of the DM1 analogue impurities. It can also be used for the related substances determination in DM1 bulk samples.
Neural Community Search with Compressed Graph Embeddings
Authors: Wang Yuxiang , Wu Xiangying , Gou Xiaoxuan , Xu Xiaoliang , Wu Tianxing , Ke Xiangyu , Suzuki Yoshimi , Geng Yuxia , Chen Runhuai , Yu Zhiyuan 
Published: July 2024

Abstract

Given a graph $G$ and a query node $q$, community search (CS) aims to find a cohesive subgraph from $G$ that contains $q$ as the desired community of $q$. CS is a fundamental problem in graph data analytics that has gained much research interest. Recently, a new thought of using the deep learning model to support CS has emerged. Supervised models using Graph Neural Networks are presented (i.e., neural community search). However, the lack of explicit consideration for community features results in suboptimal graph embeddings for online community inference, which adversely affects search accuracy. This motivates our solutions. (1) We first present an offline community-injected graph embedding method that incorporates community cohesiveness features into the learned node representations, ensuring the effectiveness of CS. Next, we present a self-augmented method based on KL divergence to optimize node representations. Then, we conduct an efficient online community search based on the enhanced node representations, by employing inner product operation between $q$ and other candidate nodes. (2) To reduce the memory usage of online community search, we employ an Encoder-Decoder model that achieves nearly lossless compression of graph embeddings, while maintaining the effectiveness of online CS. Comprehensive experimental studies on eight real-world datasets show our solution's superiority on effectiveness (at least 9.6\% improvement) and efficiency (one to two orders of magnitude faster). Notably, the proposed optimized solution with compressed graph embeddings achieves a comparable performance with the one without compression, while using only 15.2\% (on average) of the memory usage in online community search.
Urban and Non-Urban Contributions to the Social Cost of Carbon
Authors: Estrada Francisco , Lupi Veronica , Botzen W.J. Wouter , Tol Richard 
Published: July 2024

Abstract

The social cost of carbon (SCC) serves as a concise measure of climate change's economic impact, often reported at the global and country level. SCC values tend to be disproportionately high for less-developed, populous countries. Previous studies do not distinguish between urban and non-urban areas and ignore the synergies between local and global warming. High exposure and concurrent socioenvironmental problems exacerbate climate change risks in cities. Using a spatially explicit integrated assessment model, the SCC is estimated at USD$187/tCO2, rising to USD$484/tCO2 when including urban heat island (UHI) warming. Urban SCC dominates, representing about 96% of the global SCC, due to both urban exposure and the UHI. This finding implies that the highest global greenhouse gases (GHGs) emitters also experience the largest economic losses. Global cities have significant leverage on climate policy at the national and global scales and strong incentives for a swift transition to a low-carbon economy.
Simulation of knowledge transfer in complex networks by coupling ABM and GIS: a local road freight transport system as a case study
Authors: Salas-Peña Aitor , García-Palomares Juan Carlos 
Published: July 2024

Abstract

Some complex social networks are driven by adaptive and co-evolutionary patterns. However, these can be difficult to detect and analyse since the links between actors are circumstantial and often not revealed. This paper employs a GIS-integrated agent-based approach to simulate co-evolution in a complex social network. A case study is proposed for the modelling of contractual relationships between road freight transport companies. The model employs empirical data from a survey of transport companies located in the Basque Country (Spain) and utilises a community detection algorithm to observe the effect of cluster size in the network. Additionally, a local spatial association indicator is employed to identify potentially favourable environments. The model enables the evolution of the network, leading to more complex collaborative structures. By means of iterative simulations, the study demonstrates how collaborative networks self-organise by distributing activity and knowledge and evolving into complex polarised systems. Furthermore, the simulations with different minimum cluster sizes indicate that clusters benefit the agents that are part of them, although they are not a determining factor in the network participation of other non-clustered agents.