bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent progress in melasma pathogenesis
Authors: Lee Ai‐Young 
Published: July 2015

SummaryMelasma is a common skin pigmentation condition. Given therapeutic difficulty as one of the biggest concerns, understanding of the etiology and pathogenesis of melasma becomes essential. UV irradiation, female sex hormones, and inflammatory processes are addressed as triggering factors with genetic predisposition. The mechanism of UV‐induced melanogenesis has been extensively investigated as a model system to study melasma pathogenesis. Hitherto, treatment modalities for melasma are similar to other hyperpigmentation disorders. However, individual triggering factors induce a separate pigmentation disease, whose pathogenic mechanisms and clinical phenotypes are different from the ones encountered in melasma. Fortunately, there have been ongoing updates on melasma pathogenesis with regard to major triggering factors. Presence of certain factors working independently of UV exposure and role of dermal factors and microRNAs are being identified as novel discoveries about melasma pathogenesis. In this review, the melasma pathogenesis is reviewed in association with updated and new findings.
Pediatric Toxic Epidermal Necrolysis: Experience of a Tertiary Burn Center
Authors: Rizzo Julie A. , Johnson Rebekah , Cartie Richard J. 
Published: July 2015

AbstractBackgroundPediatric toxic epidermal necrolysis (TEN) is a rare and potentially fatal skin disease with a multitude of causative factors and no consensus on treatment guidelines and, as a result, it has a variety of short‐ and long‐term outcomes. We present the experience of a large specialty burn center to share our diagnostic and treatment principles.MethodsA retrospective review from 1989 to 2010 at the Joseph M. Still Burn Center was performed to find patients with a diagnosis of Steven–Johnson syndrome (SJS) or TEN. Information was obtained on demographic and physiologic parameters such as age, race, total body surface area involved, treatments, hospital stay, and need for ventilator support.ResultsWe identified SJS or TEN in 21 patients. Prescription drugs were the most common etiology (in 15 patients), with antibiotics as the most common causative agent. Histology confirmed the clinical diagnosis of TEN in 14 patients. Our treatment plan included a multidisciplinary team, early initiation of intravenous immunoglobulin, bronchoscopy, strict management of electrolyte and fluid balances, and meticulous surgical wound care. Mortality was 9.5%.ConclusionOur experience in treating this rare but devastating disease affords us the opportunity to share the diagnostic dilemmas we faced and the treatment principles we used to treat this unique patient population successfully.
Successful treatment of secondary graft failure following unrelated cord blood transplant with hematopoietic growth factors in a pediatric patient with Fanconi anemia
Authors: Buchbinder David , Hsieh Loan , Mahajerin Arash , Puthenveetil Geetha , Soni Amit , Nugent Diane 
Published: July 2015

AbstractGraft failure following allogeneic HCT in Fanconi anemia is associated with significant mortality. Retransplantation may be considered; however, the limited toxicity profile of HGFs also makes them an option for the treatment of graft failure. We describe a five‐yr‐old female diagnosed with Fanconi anemia and marrow failure treated with HCT. The course was complicated by secondary graft failure treated successfully with HGFs including G‐CSF, EPO, and romiplostim. The outcome could be related to the intervention, but could also be the natural course of recovery, including recovering from a recent CMV infection treated with ganciclovir. We found the use of HGFs to be an effective and safe alternative to the potential complications as well as morbidity and mortality associated with the use of retransplantation.
The western segment of the suture between the Yangtze and Cathaysia blocks: constraints from inherited and co‐magmatic zircons from Permian S‐type granitoids in Guangxi, South China
Authors: Qiao Long , Wang Qingfei , Li Chusi 
Published: July 2015

AbstractThe location of the suture between the Yangtze craton and the Cathaysia block is uncertain in the west. Three proposed locations for the western segment of the suture all go through Guangxi but are up to ~150 km apart. Inherited zircon crystals from the Darongshan Permian S‐type granitoid plutons, which are derived from the lower crust and occur north of the southernmost location for the suture, yield U–Pb ages with a major peak at ~960 Ma. The εHf(t) values of the inherited zircons with ages around the major peak vary from +6.4 to −23.4. The age distribution and Hf isotope variations of the inherited zircons are remarkably similar to those of Precambrian detrital zircon crystals from the western Cathaysia block but strikingly different from those of Precambrian detrital zircon crystals from the Yangtze craton. These results indicate that the western part of the suture is situated to the north of the Darongshan granitoid belt.
Virulence Factor Genes Detected in the Complete Genome Sequence of Corynebacterium uterequi DSM 45634, Isolated from the Uterus of a Maiden Mare
Authors: Rückert Christian , Kriete Martin , Jaenicke Sebastian , Winkler Anika , Tauch Andreas 
Published: July 2015

ABSTRACT

The complete genome sequence of the type strain
Corynebacterium uterequi
DSM 45634 from an equine urogenital tract specimen comprises 2,419,437 bp and 2,163 protein-coding genes. Candidate virulence factors are homologs of DIP0733, DIP1281, and DIP1621 from
Corynebacterium diphtheriae
and of sialidase precursors from
Trueperella pyogenes
and
Chlamydia trachomatis
.
Characterization and Sequencing of a Genotype XII Newcastle Disease Virus Isolated from a Peacock (
Pavo cristatus
) in Peru
Authors: Chumbe Ana , Izquierdo-Lara Ray , Tataje-Lavanda Luis , Figueroa Aling , Segovia Karen , Gonzalez Rosa , Cribillero Giovana , Montalvan Angela , Fernández-Díaz Manolo , Icochea Eliana 
Published: July 2015

ABSTRACT
Here, we report the first complete sequence and biological characterization of a Newcastle disease virus (NDV) isolated from a peacock in South America (NDV/peacock/Peru/2011). This isolate, classified as genotype XII in class II, highlights the need for increased surveillance of noncommercial avian species.
Draft Genome Sequence of Shiga Toxin-Producing Escherichia coli Strain D92/09
Authors: Da Silva Santos Ana Carolina , Rodrigues Josias 
Published: July 2015

ABSTRACT

Escherichia coli
is suspected to be involved with Crohn's disease. Adherence and invasion to epithelial cells are properties commonly observed in these bacteria. Here, we present a draft genome sequence of
E. coli
D92/09, a multidrug-resistant strain, which besides showing these properties produces Shiga cytotoxin-1 and possibly other toxins.
Draft Genome Sequence of the Bacteriocin-Producing Bradyrhizobium japonicum Strain FN1
Authors: Kohlmeier MacLean G. , Yudistira Harry , Zhang Xiang Li , Fristensky Brian , Levin David B. , Sparling Richard , Oresnik Ivan J. 
Published: July 2015

ABSTRACT

Bradyrhizobium japonicum
strain FN1 was found to produce bacteriocin-like zones of clearing when tested against other strains of bradyrhizbia. The genome was sequenced, and several putative bacteriocin-producing genes, in addition to the expected genes involved in nodulation and nitrogen fixation, were identified.
Draft Genome Sequence of Saccharomyces cerevisiae Strain NCIM3186 Used in the Production of Bioethanol from Sweet Sorghum
Authors: Sravanthi Goud Burragoni , Ulaganathan Kandasamy 
Published: July 2015

ABSTRACT

Here, we report the draft genome sequence of
Saccharomyces cerevisiae
strain NCIM3186 used in bioethanol production from sweet sorghum. The size of the genome is approximately 11.9 Mb and contains 5,347 protein-coding genes.
Draft Genome Sequences of Five Pseudomonas fluorescens Subclade I and II Strains, Isolated from Human Respiratory Samples
Authors: Scales Brittan S. , Erb-Downward John R. , LiPuma John J. , Huffnagle Gary B. 
Published: July 2015

ABSTRACT

We report the draft genomes of five
Pseudomonas fluorescens
strains, isolated from clinical samples. Phylogenetic analysis places three in subclade I and two in subclade II of the
P. fluorescens
species complex. The average G+C content and genomic size are 63% and 7.1 Mbp (subclade I) and 59.6% and 6.14 Mbp (subclade II), respectively.
Draft Genome Sequence of the Lactobacillus agilis Strain Marseille
Authors: Drissi Fatima , Labas Noémie , Merhej Vicky , Raoult Didier 
Published: July 2015

ABSTRACT

We report the draft genome sequence of
Lactobacillus agilis
strain Marseille, isolated from stool samples of a child suffering from kwashiorkor. This strain can use two metabolic pathways allowing the assimilation of glucose and xylose. Here, we present the first draft genome of the
Lactobacillus agilis
species.
Draft Genome Sequence of the Lactobacillus mucosae Strain Marseille
Authors: Drissi Fatima , Merhej Vicky , Blanc-Tailleur Caroline , Raoult Didier 
Published: July 2015

ABSTRACT

Lactobacillus mucosae
strain Marseille, isolated from stool samples of a child suffering from a malnutrition disorder called Kwashiorkor, produces bacteriocin and seems to have specific carbohydrate and lipid metabolisms different from those of other
Lactobacillus
organisms. The draft genome sequence of this strain is presented here.
Isolation, Identification, Whole-Genome Sequencing, and Annotation of Four
Bacillus
Species, B. anthracis RIT375,
B. circulans
RIT379,
B. altitudinis
RIT380, and B. megaterium RIT381, from Internal Stem Tissue of the Insulin Plant
Costus igneus
Authors: Polter Steven J. , Caraballo Alexander A. , Lee Yin P. , Eng Wilhelm W. H. , Gan Han M. , Wheatley Matthew S. , Savka Michael A. , Thomas Bolaji N. , Hudson André O. 
Published: July 2015

ABSTRACT

Here, we report the isolation, identification, whole-genome sequencing, and annotation of four
Bacillus
species from internal stem tissue of the insulin plant
Costus igneus
, grown in Puerto Rico. The plant is of medicinal importance, as extracts from its leaves have been shown to lower blood sugar levels of hyperglycemic rats.
Draft Genome Sequences of Human-Pathogenic Escherichia coli O26:H11 Strains Carrying the
stx
2
Gene Only and Circulating in France
Authors: Delannoy Sabine , Mariani-Kurkdjian Patricia , Bonacorsi Stephane , Liguori Sandrine , Ison Sarah A. , Fach Patrick 
Published: July 2015

ABSTRACT

Shiga toxin-producing
Escherichia coli
(STEC) O26:H11 is one of the most frequent pathogens associated with diarrhea and hemolytic-uremic syndrome (HUS). In this report, we present the draft genome sequences of seven strains of STEC O26:H11 carrying the
stx
2a
or stx
2d
gene only and isolated in France from HUS patients.
First Insights into the Genome of
Fructobacillus
sp. EFB-N1, Isolated from Honey Bee Larva Infected with European Foulbrood
Authors: Djukic Marvin , Daniel Rolf , Poehlein Anja 
Published: July 2015

ABSTRACT

European foulbrood is a worldwide disease affecting the honey bee brood. Here, we report the draft genome sequence of
Fructobacillus
sp. EFB-N1, which was isolated from an infected honey bee larva derived from a Swiss European foulbrood outbreak. The genome consists of 68 contigs and harbors 1,629 predicted protein-encoding genes.
miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma
Authors: Zhang Manchao , Piao Longzhu , Datta Jharna , Lang James C. , Xie Xiujie , Teknos Theodoros N. , Mapp Anna K. , Pan Quintin 
Published: July 2015

Abstract
Epithelial-restricted with serine box (ESX), a member of the ETS transcription factor family, is elevated and regulates EGFR in head and neck squamous cell carcinoma (HNSCC). However, the molecular mechanisms that contribute to ESX dysregulation remain to be elucidated. In this study, in silico analysis of the 3′-untranslated region (UTR) of ESX predicted two miR-124–binding sites. Delivery of miR-124 inhibited the 3′UTR ESX-driven reporter activity by 50% (P &lt; 0.05) confirming ESX as a direct target of miR-124. Loss of miR-124 was found to be a frequent event in HNSCC. miR-124 expression was significantly depleted in the primary tumor compared with matched normal tissue in 100% (12/12) of HNSCC patients; relative mean miR-124 expression of 0.01197 and 0.00118 (P &lt; 0.001, n = 12) in matched normal adjacent tissue and primary HNSCC tumor, respectively. Overexpression of miR-124 decreased ESX and EGFR levels in miR-124low/ESXhigh/EGFRhigh SCC15 HNSCC cells and reduced cell invasion, migration, proliferation, and colony formation. SCC15 cells with miR-124 restoration were less tumorigenic in vivo than miR-control SCC15 cells (70% inhibition, P &lt; 0.01). Restoration of miR-124 in SCC15 cells enhanced the antiproliferative efficacy of the EGFR/Her2 tyrosine kinase inhibitors. Furthermore, recapitulation of EGFR in miR-124–overexpressing SCC15 cells was sufficient to completely block the antiproliferative effects of lapatinib and afatinib. Taken together, our work provides intriguing evidence that miR-124 is a novel therapeutic approach to reduce ESX/EGFR, and may be a tractable strategy to enhance the response rate of HNSCC patients to current anti-EGFR/Her2 therapies. Mol Cancer Ther; 14(10); 2313–20. ©2015 AACR.
Microbleed Status and 3-Month Outcome After Intravenous Thrombolysis in 717 Patients With Acute Ischemic Stroke
Authors: Turc Guillaume , Sallem Asmaa , Moulin Solène , Tisserand Marie , Machet Alexandre , Edjlali Myriam , Baron Jean-Claude , Leclerc Xavier , Leys Didier , Mas Jean-Louis , Cordonnier Charlotte , Oppenheim Catherine 
Published: July 2015

Background and Purpose—
Whether cerebral microbleeds (CMBs) detected on pretreatment magnetic resonance imaging increase the risks of symptomatic intracranial hemorrhage (sICH) and, most importantly, poor outcome in patients treated by intravenous thrombolysis for acute ischemic stroke is still debated. We assessed the effect of CMB presence and burden on 3-month modified Rankin Scale and sICH in a multicentric cohort.

Methods—
We analyzed prospectively collected data of consecutive patients solely treated by intravenous thrombolysis for acute ischemic stroke, in 2 centers where magnetic resonance imaging is the first-line pretreatment imaging. Neuroradiologists blinded to clinical data rated CMBs on T2* sequence using a validated scale. Logistic regressions were used to assess relationships between CMBs and 3-month modified Rankin Scale or sICH.

Results—

Among 717 patients, 150 (20.9%) had ≥1 CMBs. CMB burden was associated with worse modified Rankin Scale in univariable shift analysis (odds ratio, 1.07; 95% confidence interval, 1.00–1.15 per 1-CMB increase;
P
=0.049), but significance was lost after adjustment for age, hypertension, and atrial fibrillation (odds ratio, 1.03; 95% confidence interval, 0.96–1.11 per 1-CMB increase;
P
=0.37). Results remained nonsignificant when taking into account CMB location or presumed underlying vasculopathy. The incidence of sICH ranged from 3.8% to 9.1%, depending on the definition. Neither CMB presence, burden, location, nor presumed underlying vasculopathy was independently associated with sICH.

Conclusions—
Poor outcome or sICH was not associated with CMB presence or burden on pre–intravenous thrombolysis magnetic resonance imaging after adjustment for confounding factors. An individual patient data meta-analysis is needed to determine whether a subgroup of patients with CMBs carries an independent risk of poor outcome that might outweigh the expected benefit of intravenous thrombolysis.
Deferoxamine, Cerebrovascular Hemodynamics, and Vascular Aging
Authors: Sorond Farzaneh A. , Tan Can Ozan , LaRose Sarah , Monk Andrew D. , Fichorova Raina , Ryan Stanthia , Lipsitz Lewis A. 
Published: July 2015

Background and Purpose—
Iron chelation therapy is emerging as a novel neuroprotective strategy. The mechanisms of neuroprotection are diverse and include both neuronal and vascular pathways. We sought to examine the effect of iron chelation on cerebrovascular function in healthy aging and to explore whether hypoxia-inducible transcription factor-1 activation may be temporally correlated with vascular changes.

Methods—
We assessed cerebrovascular function (autoregulation, vasoreactivity, and neurovascular coupling) and serum concentrations of vascular endothelial growth factor and erythropoietin, as representative measures of hypoxia-inducible transcription factor-1 activation, during 6 hours of deferoxamine infusion in 24 young and 24 older healthy volunteers in a randomized, blinded, placebo-controlled cross-over study design. Cerebrovascular function was assessed using the transcranial Doppler ultrasound. Vascular endothelial growth factor and erythropoietin serum protein assays were conducted using the Meso Scale Discovery platform.

Results—

Deferoxamine elicited a strong age- and time-dependent increase in the plasma concentrations of erythropoietin and vascular endothelial growth factor, which persisted ≤3 hours post infusion (age effect
P
=0.04; treatment×time
P
<0.01). Deferoxamine infusion also resulted in a significant time- and age-dependent improvement in cerebral vasoreactivity (treatment×time
P
<0.01; age
P
<0.01) and cerebral autoregulation (gain: age×time×treatment
P
=0.04).

Conclusions—
Deferoxamine infusion improved cerebrovascular function, particularly in older individuals. The temporal association between improved cerebrovascular function and increased serum vascular endothelial growth factor and erythropoietin concentrations is supportive of shared hypoxia-inducible transcription factor-1–regulated pathways. Therefore, pharmacological activation of hypoxia-inducible transcription factor-1 to enhance cerebrovascular function may be a promising neuroprotective strategy in acute and chronic ischemic syndromes, especially in elderly patients.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT013655104.
Objective Diagnostics and the Madden–Julian Oscillation. Part II: Application to Moist Static Energy and Moisture Budgets
Authors: Wolding Brandon O. , Maloney Eric D. 
Published: July 2015

Abstract
Processes controlling moisture variations associated with the MJO are investigated using budgets of moist static energy (MSE) and moisture. To first order, precipitation anomalies are maintained by anomalous large-scale vertical moisture advection, which can be understood through application of a weak temperature gradient balance framework to the MSE budget. Intraseasonal variations in longwave radiative cooling play a crucial role in destabilizing the MJO by enhancing intraseasonal variations in large-scale vertical moisture advection. This enhancement allows the effect of intraseasonal variations in large-scale vertical moisture advection to meet or exceed the effect of intraseasonal variations in net condensation, resulting in a positive feedback between the net effect of these processes and moisture anomalies. Intraseasonal variations in surface latent heat flux (SLHF) enhance this positive feedback, but appear to be insufficient to destabilize the MJO in the absence of radiative feedbacks.
The effect an ensemble cloud population has on large-scale moisture is investigated using fields where only high-frequency variability has been removed. During the enhanced phase, approximately 85% of the moisture removed by net condensation is resupplied by the large-scale vertical moisture advection associated with apparent heating by microphysical processes and subgrid-scale vertical fluxes of dry static energy. This suggests that a relatively large increase in net condensation could be supported by a relatively small anomalous moisture source, even in the absence of radiative feedbacks. These results highlight the importance of process-oriented assessment of MJO-like variability within models, and suggest that a weak temperature gradient (WTG) balance framework may be used to identify destabilization mechanisms, thereby distinguishing between MJO-like variability of fundamentally different character.
Factors affecting stigma toward suicide and depression: A Korean nationwide study
Authors: Park Soowon , Kim Min-Ji , Cho Maeng Je , Lee Jun-Young 
Published: July 2015

Background: Suicide attempts and depression are considerably misunderstood by Korean society. Studies regarding factors should provide basic information concerning the factors that should be considered when examining stigmatization. Aim: This study aimed to investigate sociodemographic factors related to the social stigma toward people with a history of suicide attempts or depression in a Korean nationwide community sample. Method: Face-to-face interviews were conducted with participants selected via a multi-stage cluster sampling method; 779 respondents completed Link’s Perceived Devaluation and Discrimination (PDD) scale to assess the social stigma they attached to suicide attempts, and another 743 completed PDD scale to assess the social stigma they attached to depression. Multiple regression analysis, including socioeconomic and psychiatric variables, was performed to identify the factors predictive of social stigma. Results: Results of multiple regressions revealed that age ( β = .12, p = .018), sex ( β = .08, p = .038), years of education ( β = −.31, p = .006) and history of suicide attempts ( β = −.11, p = .009) significantly predicted the degree of stigma toward people who had made suicide attempts, whereas age ( β = .15, p = .003) and education ( β = −.40, p = .001) also predicted the social stigma toward people with depression, sex and history of a depressive episode did not. Conclusion: Older men with less education and no experience with suicide perceived suicide attempts more negatively. Similarly, older people with less education placed a greater stigma on people suffering from depression. These results suggest that greater access to higher education may reduce stigma toward people with mental illness.