bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Effectiveness of Wide Antral Versus Ostial Pulmonary Vein Isolation
Authors: Proietti Riccardo , Santangeli Pasquale , Di Biase Luigi , Joza Jacqueline , Bernier Martin Louis , Wang Yang , Sagone Antonio , Viecca Maurizio , Essebag Vidal , Natale Andrea 
Published: January 2014

Background—
For the past decade, electric pulmonary vein isolation (PVI) has become a procedure implemented worldwide for the treatment of atrial fibrillation. Currently, 2 main approaches are used for PVI: ostial isolation of the PVs and wide antral PVI. The aims of this systematic review are to evaluate the relative merits of each technique with a pooled comparative analysis of efficacy and complications.

Methods and Results—

Studies were identified by searching electronic databases for studies on ostial versus antral PVI. Information was extracted from each included trial. Odds ratio was the primary measure of treatment effect or side effects. The proportion of patients with recurrences of atrial fibrillation or other atrial tachyarrhythmias was evaluated at the end of the follow-up periods in 12 trials, including 1183 patients. The recurrence rate of total supraventricular arrhythmias was significantly lower in wide antral than in segmental PVI group (odds ratio, 0.42; 95% confidence interval, 0.32–0.56;
P
<0.00001). Atrial fibrillation recurrence was significantly lower in the wide antral group (odds ratio, 0.33; 95% confidence interval, 0.24–0.46;
P
<0,00001). A trend toward a higher incidence of left atrial tachycardia occurrence in the wide antral circumferential ablation group was detected, which did not reach statistical significance (odds ratio, 1.53; 95% confidence interval, 0.88–2.69;
P
=0.13).

Conclusions—
Our primary finding is that PVI performed with a wide antral approach is more effective than ostial PVI in achieving freedom from total atrial tachyarrhythmia recurrence at long-term follow-up.
Assessing Reperfusion With Whole-Brain Arterial Spin Labeling
Authors: Mirasol Raymond V. , Bokkers Reinoud P.H. , Hernandez Daymara A. , Merino José G. , Luby Marie , Warach Steven , Latour Lawrence L. 
Published: January 2014

Background and Purpose—
Arterial spin labeling (ASL) is a perfusion imaging technique that does not require gadolinium. The study aimed to assess the reliability of ASL for evaluating reperfusion in acute ischemic stroke in comparison with dynamic susceptibility contrast (DSC) imaging.

Methods—
The study included 24 patients with acute ischemic stroke on admission and 24-hour follow-up ASL and DSC scans. Two readers rated images for interpretability and evidence of reperfusion. Cohen unweighted κ was used to assess (1) inter-rater reliability between readers for determining interpretability and the presence of reperfusion, (2) agreement between ASL and DSC for determining reperfusion for individual raters, and (3) agreement between ASL and DSC for determining reperfusion after consensus.

Results—
Inter-rater reliability for both ASL and DSC was moderate to good (κ of 0.67 versus 0.55, respectively). Reader 1 rated 16 patients as having interpretable ASL and DSC when compared with 15 patients for reader 2. The κ between ASL and DSC for determining reperfusion was 0.50 for reader 1 and 0.595 for reader 2. After consensus, 18 ASL and 17 DSC image sets were rated interpretable for reperfusion and 13 had both interpretable ASL and DSC scans, yielding a κ for assessment of reperfusion of 0.8.

Conclusions—
Inter-rater reliability of ASL and DSC was moderate to good. Agreement between ASL and DSC for determining reperfusion was moderate for each individual rater and increased substantially after consensus. ASL is a noninvasive and practical alternative to DSC for reperfusion assessments in patients with confirmed acute ischemic stroke.
Stable Boundary Layer and Its Impact on Tropical Cyclone Structure in a Coupled Atmosphere–Ocean Model
Authors: Lee Chia-Ying , Chen Shuyi S. 
Published: January 2014

Abstract
The atmospheric boundary layer (BL) in tropical cyclones (TCs) connects deep convection within rainbands and the eyewall to the air–sea interface. Although the importance of the BL in TCs has been widely recognized in recent studies, how physical processes affect TC structure and intensity are still not well understood. This study focuses on a particular physical mechanism through which a TC-induced upper-ocean cooling within the core circulation of the TC can affect the BL and TC structure. A coupled atmosphere–ocean model forecast of Typhoon Choi-Wan (2009) is used to better understand the physical processes of air–sea interaction in TCs. A persistent stable boundary layer (SBL) is found to form over the cold wake within the TC’s right-rear quadrant, which influences TC structure by suppressing convection in rainbands downstream of the cold wake and enhancing the BL inflow into the inner core by increasing inflow angles over strong SST and pressure gradients. Tracer and trajectory analyses show that the air in the SBL stays in the BL longer and gains extra energy from surface heat and moisture fluxes. The enhanced inflow helps transport air in the SBL into the eyewall. In contrast, in the absence of a TC-induced cold wake and an SBL in an uncoupled atmosphere model forecast, the air in the right-rear quadrant within the BL tends to rise into local rainbands. The SBL formed over the cold wake in the coupled model seems to be a key feature that enhances the transport of high energy air into the TC inner core and may increase the storm efficiency.
A Novel Financial Market for Mitigating Hurricane Risk. Part II: Empirical Validation
Authors: Meyer Robert J. , Horowitz Michael , Wilks Daniel S. , Horowitz Kenneth A. 
Published: January 2014

AbstractThis paper explores the empirical features of a novel commodity option trading instrument described in the companion paper (Part I) that allows market participants to hedge against the risk that a coastal county or region in the eastern United States will experience a hurricane landfall. In this instrument investors can speculate on whether a landfall event will occur in any one of a number of coastal counties or regions, with option prices being determined by an adaptive control algorithm that reflects previous purchasing decisions of other market participants. In this paper, the authors report the results of an experiment designed to test the empirical robustness of this mechanism using data from traders buying landfall options over the course of a simulated hurricane season. In the experiment traders are given the opportunity to buy landfall options in the primary market as well as sell and buy options in a conventional bilateral secondary market. The data show that aggregate market prices quickly converge to rational (efficient) levels among market participants after limited amounts of trading experience. Some systematic anomalies are observed in the trading of options for individual outcomes, however, with the most notable being an initial tendency to overvalue landfall options that have the highest prior probabilities and for valuations of the “No Landfall” option to be inflated immediately after a storm threat passes without making landfall.
Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts
Authors: van Bladel Esther R. , Laarhoven Annemieke G. , van der Heijden Laila B. , Heitink-Pollé Katja M. , Porcelijn Leendert , van der Schoot C. Ellen , de Haas Masja , Roest Mark , Vidarsson Gestur , de Groot Philip G. , Bruin Marrie C. A. 
Published: January 2014

Key PointsPediatric chronic ITP patients with a severe bleeding phenotype exhibit functional platelet defects. The platelet microaggregation test and the platelet reactivity assay are able to assess platelet function at extremely low platelet count.
Robust isolation of malignant plasma cells in multiple myeloma
Authors: Frigyesi Ildikó , Adolfsson Jörgen , Ali Mina , Kronborg Christophersen Mikael , Johnsson Ellinor , Turesson Ingemar , Gullberg Urban , Hansson Markus , Nilsson Björn 
Published: January 2014

Key Points
Molecular characterization of myeloma requires isolation of malignant plasma cells, which is currently hampered by the instability of CD138. We identified CD319 and CD269 as robust replacements for CD138, facilitating molecular diagnostics in myeloma.
Efficacy of Metarhizium anisopliae isolate MAX-2 from Shangri-la, China under desiccation stress
Authors: Chen Zi-Hong , Xu Ling , Yang Feng-lian , Ji Guang-Hai , Yang Jing , Wang Jian-Yun 
Published: January 2014

Abstract

Background

Metarhizium anisopliae, a soil-borne entomopathogen found worldwide, is an interesting fungus for biological control. However, its efficacy in the fields is significantly affected by environmental conditions, particularly moisture. To overcome the weakness of Metarhizium and determine its isolates with antistress capacity, the efficacies of four M. anisopliae isolates, which were collected from arid regions of Yunnan Province in China during the dry season, were determined at different moisture levels, and the efficacy of the isolate MAX-2 from Shangri-la under desiccation stress was evaluated at low moisture level.

Results

M. anisopliae isolates MAX-2, MAC-6, MAL-1, and MAQ-28 showed gradient descent efficacies against sterile Tenebrio molitor larvae, and gradient descent capacities against desiccation with the decrease in moisture levels. The efficacy of MAX-2 showed no significant differences at 35% moisture level than those of the other isolates. However, significant differences were found at 8% to 30% moisture levels. The efficacies of all isolates decreased with the decrease in moisture levels. MAX-2 was relatively less affected by desiccation stress. Its efficacy was almost unaffected by the decrease at moisture levels > 25%, but slowly decreased at moisture levels < 25%. By contrast, the efficacies of other isolates rapidly decreased with the decrease in moisture levels. MAX-2 caused different infection characteristics on T. molitor larvae under desiccation stress and in wet microhabitat. Local black patches were found on the cuticles of the insects, and the cadavers dried without fungal growth under desiccation stress. However, dark black internodes and fungal growth were found after death of the insects in the wet microhabitat.

Conclusions
MAX-2 showed significantly higher efficacy and superior antistress capacity than the other isolates under desiccation stress. The infection of sterile T. molitor larvae at low moisture level constituted a valid laboratory bioassay system in evaluating M. anisopliae efficacy under desiccation stress.
Detection of drug effects on gastric emptying and contractility using a wireless motility capsule
Authors: Rozov-Ung Inna , Mreyoud Amjad , Moore John , Wilding Gregory E , Khawam Elias , Lackner Jeffrey M , Semler John R , Sitrin Michael D 
Published: January 2014

Abstract

Background
A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility.

Methods
15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer’s software.

Results
GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance.

Conclusions
A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders.
Sublingual buprenorphine for acute renal colic pain management: a double-blind, randomized controlled trial
Authors: Payandemehr Pooya , Jalili Mohammad , Mostafazadeh Davani Babak , Dehpour Ahmad Reza 
Published: January 2014

Abstract

Background
The aim of this study was to compare the efficacy and safety of sublingual buprenorphine with intravenous morphine sulfate for acute renal colic in the emergency department.

Methods
In this double-dummy, randomized controlled trial, we enrolled patients aged 18 to 55 years who had a clinical diagnosis of acute renal colic. Patients received either 2 mg sublingual buprenorphine with an IV placebo, or 0.1 mg/kg IV morphine sulfate with a sublingual placebo. Subjects graded their pain with a standard 11-point numeric rating scale (NRS) before medication administration and 20 and 40 minutes after that. The need for rescue analgesia and occurrence of side effects were also recorded in the two groups.

Results
Of 69 patients analyzed, 37 had received buprenorphine, and 32 had taken morphine. Baseline characteristics were similar in both groups. NRS pain scores were reduced across time by administration of both buprenorphine (from 9.8 to 5.22 and then 2.30) and morphine (from 9.78 to 4.25 and then 1.8), significantly (P <0.0001). The two regimens did not differ significantly for pain reduction (P?=?0.260). Dizziness was more frequently reported by the buprenorphine group (62.1% versus 37.5%, P <0.05) but other adverse effects observed within 40 minutes were similar in the two groups.

Conclusions
Sublingual buprenorphine (2 mg) is as effective as morphine sulfate (0.1 mg/kg) in acute renal colic pain management.
Significant dose Escalation of Idarubicin in the treatment of aggressive Non- Hodgkin Lymphoma leads to increased hematotoxicity without improvement in efficacy in comparison to standard CHOEP-14: 9-year follow up results of the CIVEP trial of the DSHNHL
Authors: Hohloch Karin , Zwick Carsten , Ziepert Marita , Hasenclever Dirk , Kaiser Ulrich , Engert Andreas , Höffkes Heinz-Gert , Kroschinsky Frank , Mesters Rolf , Feller Andreas C , Löffler Markus , Trümper Lorenz , Pfreundschuh Michael 
Published: January 2014

Abstract

Background
Dose escalation and modification of CHOP has improved the prognosis of patients with aggressive lymphoma; even in the rituximab era, dose escalation for high-risk patients is exploited and frequently limited by drug toxicity. Idarubicin (Id) is a 4-demethoxy anthracycline analogue of daunorubicin with activity against lymphoma and has been reported to cause less cardiotoxicity than other anthracylines. The aim of this study was to replace doxorubicine with idarubicin in the CHOEP regimen and to find the maximum tolerable dose (MTD) of idarubicin based on hematotoxicity.

Patients and methods
Between 11/96 and 09/98, 64 patients (pts) aged 18–75 yrs (pts. 18–60, LDH not elevated, >60 years all risk groups) with newly diagnosed aggressive lymphoma received 6 cycles of CIVEP-14 with an escalating dose of idarubicin, consisting of idarubicin (11–16 mg/m2 d1) and standard doses of cyclophosphamide, vincristine, etoposide, and prednisone with G-CSF support.

Results
55 pts (median age 56 yrs) were evaluable for a final analysis with a median observation time of 9.3 years. The CR-rate was 77.4% ; the 5 and 8-year-EFS rates were 46.4% (95%CI 32.5-60.3%) and 43.5% (29.4-57.6%), respectively, and the 5- and 8 yr OS rates were 64.6% (51.7-77.5%) and 59.9% (46.4-73.4%). 14/55 patients have died due to lymphoma progression, and 2/55 patients (3.6%) due to treatment related toxicity, 4/55 due to other causes (3 infections, 1 acute heart failure). In a matched pair analysis comparing CHOEP-14 and CIVEP-14, CIVEP-14 had a higher hematotoxicity with no significant differences in the event free and overall survival for the two regimens.

Conclusions
Thus, idarubicin cannot be used instead doxorubicin even if its dose is escalated to achieve similar hematotoxicity. Doxorubicin remains the standard anthracycline for the treatment of aggressive NHL.
Novel intracellular functions of apolipoproteins: the ApoO protein family as constituents of the Mitofilin/MINOS complex determines cristae morphology in mitochondria
Authors: Koob Sebastian , Reichert Andreas S. 
Published: January 2014

Abstract
Mitochondria exist in a highly dynamic network that is constantly altered by fusion and fission events depending on various factors such as cellular bioenergetic state and cell cycle. Next to this dynamic nature of the organelle, its cristae membrane also undergoes drastic morphological changes upon physiological or pathological alterations. The Mitofilin/mitochondrial inner membrane organizing system (MINOS) complex was recently reported to ensure mitochondrial architecture and crista junction integrity. Several subunits of this complex are linked to a diverse set of neurological human disorders. Recently, two apolipoproteins, ApoO (APOO) and ApoO-like (APOOL) were suggested to represent constituents of the mammalian Mitofilin/MINOS complex. APOOL was shown to bind the mitochondrial phospholipid cardiolipin (CL) and to interact physically with this complex. In this review we highlight the current view on the mammalian Mitofilin/MINOS complex and focus on APOOL and the role of CL in determining cristae morphology. We will discuss possible functions of the Mitofilin/MINOS complex on lipid transport, on assembly of respiratory supercomplexes, on F1FO-ATP synthase organization, on contact site formation, and on trapping CL within the cristae subcompartment.
Cat-Scratch Disease In Adult Hospitalized For Prolonged-Fever Associated With Multiple Lymphadenopathies and Weight Loss
Authors: Guiyedi Vincent , Haddad Hanna , Okome-Nkoumou Madeleine , Gire Fabien , Ongali Brice , Lore Philippes , Gameiro Luis 
Published: January 2014

We report a 19-year-old patient with a Cat-scratch disease presenting three months continuous alteration of the general condition, including prolonged-fever, anorexia, asthenia, weight loss associated with adenitis and multiple thoracic-abdominal adenopathies, leukocytosis with neutrophil polynuclear predominance, and increased of C-reactive protein. The serologies of toxoplasmosis, infectious mononucleosis, human immunodeficiency virus, Brucellosis, Bartonellosis and the tuberculosis research by tuberculin reaction test and Ziehl acid-alcohol resistant bacilli direct examination were negatives. The cytomegalovirus and Epstein-Barr virus serologies were positives only for immunoglobulin-G. The Bartonella henselae diagnosis was made with the analysis of histopathological specimens. The clinical and biological symptoms regressed following eight weeks of azithromycin's treatment.
According to this observation, the cat-scratch disease should be considered in differential diagnosis of patients presenting prolonged-fever associated with multiple lymphadenopathies and weight loss. The azithromycin would be an alternative therapeutic issue for this pathology in case of confirmed efficacy by studies in a large patient population.
Potential Contradictions Connected to the Inclusion of Stable Schools in
the Legislation for Danish Organic Dairy Farms
Authors: M. Vaarst , I. Fisker 
Published: January 2014

This article aims to raise questions and discuss how a previous farmer-driven group approach (Stable Schools)
works under a legislation framework as a part of an obligatory health advisory service for Danish organic dairy producers.
The study takes its starting point in an on-line questionnaire evaluation (79 farmer respondents) conducted after one year
(2011) with the Stable School approach as part of the legislation. This is followed by a discussion on the perspectives of
‘obligatory farmer groups’ supported by literature on experience from other institutionalized advisory approaches.
Respondents generally found the Stable Schools useful for many organic farmers, also after introduction to the legislation,
given that farmers are motivated and the process is actively supported by a skilled facilitator. We raise the question of a
potential mismatch between the legislative aims and the farmer group approach. Shifts between different advisory approaches
at the farm level can potentially stimulate continuous on-farm development.
Validating Emergency Department Vital Signs Using a Data Quality Engine for Data Warehouse
Authors: Genes N , Chandra D , Ellis S , Baumlin K 
Published: January 2014

Background:
Vital signs in our emergency department information system were entered into free-text fields for heart rate, respiratory rate, blood pressure, temperature and oxygen saturation.

Objective:
We sought to convert these text entries into a more useful form, for research and QA purposes, upon entry into a data warehouse.

Methods:
We derived a series of rules and assigned quality scores to the transformed values, conforming to physiologic parameters for vital signs across the age range and spectrum of illness seen in the emergency department.

Results:
Validating these entries revealed that 98% of free-text data had perfect quality scores, conforming to established vital sign parameters. Average vital signs varied as expected by age. Degradations in quality scores were most commonly attributed logging temperature in Fahrenheit instead of Celsius; vital signs with this error could still be transformed for use. Errors occurred more frequently during periods of high triage, though error rates did not correlate with triage volume.

Conclusions:
In developing a method for importing free-text vital sign data from our emergency department information system, we now have a data warehouse with a broad array of quality-checked vital signs, permitting analysis and correlation with demographics and outcomes.
Development of an Anomaly Detection Model for a Bank's Transitory Account System
Authors: Kim Yongbum , Kogan Alexander 
Published: January 2014

ABSTRACT
Fraud detection is one of the key components of an internal control system that is designed to provide reasonable assurance regarding reliable financial statements, effective and efficient operations, compliance with applicable laws and regulations, and safeguarding of assets (AICPA 2002; Committee of Sponsoring Organizations of the Treadway Commission 1992). Practically, however, it is challenging to determine what should be investigated among myriads of a company's transactions, most of which are normal and/or free from material error. Limited human resources and cost constraints are major barriers to fraud detection in practice. This study proposes a multi-step fraud detection model that screens transactions at various levels, which leads to a manageable number of transactions that internal auditors can examine. To that end, a broad screening criterion is applied at the highest level, while more detailed criteria are used at the lowest level. This study provides an example of development of a practicable fraud detection model.