bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life among pediatric patients with cancer: Contributions of time since diagnosis and parental chronic stress
Authors: Hamner Taralee , Latzman Robert D. , Latzman Natasha E. , Elkin T. David , Majumdar Suvankar 
Published: March 2015

BackgroundPediatric cancer is associated with a host of negative psychosocial consequences; however, outcomes vary extensively suggesting a need to better understand this variation. Empirical research suggests a positive association between time since diagnosis (TSD) and Quality of Life (QoL). In addition to TSD, family stressors have been found to be particularly important in predicting QoL among children. The current study examined parental chronic stress beyond TSD in explanation of QoL functioning among a sample of pediatric patients with cancer.ProcedureParticipants included 43 pediatric patients aged 5–18 years (Mage = 10.2 ± 3.6) who were undergoing oncological treatment. Parents reported on TSD, child's QoL, and their own chronic stress.ResultsTSD was associated with greater physical functioning (r = 0.30, P < 0.05). Parental chronic stress was associated with poorer emotional (r = −0.54, P < 0.01), physical (r = −0.41, P < 0.01), and social functioning (r = −0.44, P < 0.01). Further, hierarchal linear regression analyzes indicated parental chronic stress contributed incrementally beyond TSD in the explanation of physical (β = −0.37, t = −2.58, P < 0.01), emotional (β = −0.47, t = −3.51, P < 0.00), and social functioning (β = −0.38, t = −2.67, P < 0.01).ConclusionsParental chronic stress is associated with reduced levels of emotional, physical, and social functioning among pediatric patients. Future research is needed to further investigate the process by which chronic stress within the family interferes with adaptive coping among pediatric patients. In addition, clinical services may benefit from increased consideration of family factors, such as parental chronic stress, during oncological treatment. Pediatr Blood Cancer 2015;62:1232–1236. © 2015 Wiley Periodicals, Inc.
Does prenatal MRI enhance fetal diagnosis of intra‐abdominal cysts?
Authors: Hugele Florence , Dumont Coralie , Boulot Pierre , Couture Alain , Prodhomme Olivier 
Published: March 2015

AbstractObjectiveThe aim of this study was to evaluate the contribution of prenatal magnetic resonance imaging (MRI) to ultrasound (US) in the prenatal diagnosis of intra‐abdominal cystic masses, correlated with the postnatal diagnosis.MethodsIn this retrospective, observational study, prenatal MRI and US diagnoses were compared with postnatal diagnoses. MRI was performed in 56 fetuses with intra‐abdominal cyst diagnosed by US between 2004 and 2013. Final diagnosis, revealed by postnatal evaluation, was obtained for 49 of them and was taken as the reference. MRI was evaluated as superior, equal, or inferior to US.ResultsAn accurate diagnosis was provided by US in 25 cases (51%) and by MRI in 36 out of the 49 cases (73.4%). MRI corrected the US diagnosis in 13 cases (26.5%) by providing a more precise localization or additional etiologic information. In two cases (4%), MRI wrongly changed the diagnosis correctly made by US.ConclusionPrenatal MRI better characterized the nature of abdominal cystic lesions previously diagnosed by US in 13 cases. This enhanced postnatal therapeutic planning and so improved parental counseling and pregnancy management. © 2015 John Wiley & Sons, Ltd.
Infant pulmonary function testing in chronic pneumonitis of infancy due to surfactant protein C mutation
Authors: Hevroni Avigdor , Goldman Aliza , Springer Chaim 
Published: March 2015

SummaryPulmonary function testing is a vital tool in evaluation and management of adult ILD patients and is rarely overlooked during workup. However, there is paucity of data regarding its usefulness in management of infants with suspected interstitial lung disease. In this paper, we present the contribution of infant pulmonary function testing (iPFT) to the management of two infants with biopsy confirmed chronic pneumonitis of infancy due to surfactant protein C mutation. We have productively and safely used serial iPFT for decision making both during diagnosis and follow‐up of these infants. Pediatr Pulmonol. 2015; 50:E17–E23. © 2015 Wiley Periodicals, Inc.
Molecular structure of an N‐formyltransferase from Providencia alcalifaciensO30
Authors: Genthe Nicholas A. , Thoden James B. , Benning Matthew M. , Holden Hazel M. 
Published: March 2015

AbstractThe existence of N‐formylated sugars in the O‐antigens of Gram‐negative bacteria has been known since the middle 1980s, but only recently have the biosynthetic pathways for their production been reported. In these pathways, glucose‐1‐phosphate is first activated by attachment to a dTMP moiety. This step is followed by a dehydration reaction and an amination. The last step in these pathways is catalyzed by N‐formyltransferases that utilize N10‐formyltetrahydrofolate as the carbon source. Here we describe the three‐dimensional structure of one of these N‐formyltransferases, namely VioF from Providencia alcalifaciens O30. Specifically, this enzyme catalyzes the conversion of dTDP‐4‐amino‐4,6‐dideoxyglucose (dTDP‐Qui4N) to dTDP‐4,6‐dideoxy‐4‐formamido‐d‐glucose (dTDP‐Qui4NFo). For this analysis, the structure of VioF was solved to 1.9 Å resolution in both its apoform and in complex with tetrahydrofolate and dTDP‐Qui4N. The crystals used in the investigation belonged to the space group R32 and demonstrated reticular merohedral twinning. The overall catalytic core of the VioF subunit is characterized by a six stranded mixed β‐sheet flanked on one side by three α‐helices and on the other side by mostly random coil. This N‐terminal domain is followed by an α‐helix and a β‐hairpin that form the subunit:subunit interface. The active site of the enzyme is shallow and solvent‐exposed. Notably, the pyranosyl moiety of dTDP‐Qui4N is positioned into the active site by only one hydrogen bond provided by Lys 77. Comparison of the VioF model to that of a previously determined N‐formyltransferase suggests that substrate specificity is determined by interactions between the protein and the pyrophosphoryl group of the dTDP‐sugar substrate.
Chemical cross‐linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex
Authors: Nguyen‐Huynh Nha‐Thi , Sharov Grigory , Potel Clément , Fichter Pélagie , Trowitzsch Simon , Berger Imre , Lamour Valérie , Schultz Patrick , Potier Noëlle , Leize‐Wagner Emmanuelle 
Published: March 2015

AbstractUnderstanding the way how proteins interact with each other to form transient or stable protein complexes is a key aspect in structural biology. In this study, we combined chemical cross‐linking with mass spectrometry to determine the binding stoichiometry and map the protein–protein interaction network of a human SAGA HAT subcomplex. MALDI‐MS equipped with high mass detection was used to follow the cross‐linking reaction using bis[sulfosuccinimidyl] suberate (BS3) and confirm the heterotetrameric stoichiometry of the specific stabilized subcomplex. Cross‐linking with isotopically labeled BS3 d0‐d4 followed by trypsin digestion allowed the identification of intra‐ and intercross‐linked peptides using two dedicated search engines: pLink and xQuest. The identified interlinked peptides suggest a strong network of interaction between GCN5, ADA2B and ADA3 subunits; SGF29 is interacting with GCN5 and ADA3 but not with ADA2B. These restraint data were combined to molecular modeling and a low‐resolution interacting model for the human SAGA HAT subcomplex could be proposed, illustrating the potential of an integrative strategy using cross‐linking and mass spectrometry for addressing the structural architecture of multiprotein complexes.
The relationship between prostate‐specific antigen and TNM classification or Gleason score in prostate cancer patients with low prostate‐specific antigen levels
Authors: Izumi Kouji , Ikeda Hiroko , Maolake Aerken , Machioka Kazuaki , Nohara Takahiro , Narimoto Kazutaka , Ueno Satoru , Kadono Yoshifumi , Kitagawa Yasuhide , Konaka Hiroyuki , Mizokami Atsushi , Namiki Mikio 
Published: March 2015

AbstractBACKGROUNDProstate‐specific antigen (PSA) is a useful biomarker for risk classification in patients with prostate cancer. However, it is unclear whether a correlation exists between low PSA levels (<10 ng/ml) at diagnosis and prognosis.METHODSOf the 642 Japanese patients who underwent prostate biopsy and were diagnosed with prostate cancer at Kanazawa University Hospital from 2000 to 2010, 406 patients with a PSA level <20 ng/ml were retrospectively reviewed.RESULTSPSA levels in 275 (68%) patients were <10 ng/ml. Although the percentage of Gleason score 8–10 in patients with a PSA level of <3.5 ng/ml was higher than that in patients with a PSA level between 3.5 and 10 ng/ml, it was not statistically significant. On the other hand, the percentage of higher stage (T3 and T4) patients with a PSA level <3.5 ng/ml was significantly greater than that in patients with a PSA level between 3.5 and 10 ng/ml (P < 0.0001). The percentage of metastases (N1 and M1) in patients with a PSA level <3.5 ng/ml was also significantly higher than that in patients with a PSA level between 3.5 and 10 ng/ml (P = 0.0112).CONCLUSIONSPatients with prostate cancer with a PSA level <3.5 ng/ml at diagnosis had a more advanced stage of cancer compared with those with a PSA level between 3.5 and 10 ng/ml. Therefore, risk classification using PSA levels at diagnosis may need to take into consideration this specific PSA range in order to better predict survival. Prostate 75:1034–1042, 2015. © 2015 Wiley Periodicals, Inc.
Modeling the Effect of Asymmetric Rolling on Mechanical Properties of Al–Mg Alloys
Authors: de Almeida Grácio José Joaquim , Vincze Gabriela , Yoon Jeong Whan , Cardoso Rui Pedro Ramos , Rauch Edgar Fernand , Barlat Frédéric Gérard 
Published: March 2015

AbstractThe mechanical behavior under uniaxial tension of Al–Mg alloy 5182 pre‐deformed in conventional rolling (CR), asymmetric rolling‐continuous (ASRC), and asymmetric rolling‐reversed (ASRR) was investigated and modeled with a rate dependent crystal plasticity finite element method and VPSC (Visco‐Plastic Self Consistent) model. M–K theory combined with Yld2000 model by Barlat et al. (Int. J. Plasticity 2003, 19, 1297) was used to predict the strain‐based and stress‐based formability for AA 5182 material. It was concluded that the new ASRR process has very compatible formability with improved strength compared to CR process. These merits can be directly applied for clam‐shell resistant design in rigid‐packaging industry.
Basal Joint Arthroplasty Decreases Carpal Tunnel Pressure
Authors: Lutsky Kevin , Ilyas Asif , Kim Nayoung , Beredjiklian Pedro 
Published: March 2015

Background There is a well-documented association between carpal tunnel syndrome (CTS) and thumb carpometacarpal (CMC) arthritis, and these conditions commonly coexist. We have observed that patients who have previously undergone thumb basal joint arthroplasty (BJA) seem rarely to present subsequently with CTS. Our hypothesis is that BJA decreases the pressure within the carpal tunnel. Methods Twenty-eight patients (6 with coexistent CTS) undergoing BJA were enrolled in the study. The pressure within the carpal tunnel immediately before and after BJA was measured using a commercially available pressure monitor device (Stryker STIC; Kalamazoo, MI). In patients with concomitant CTS undergoing both BJA and carpal tunnel release (CTR), the pressure was measured after BJA but prior to release of the transverse carpal ligament. Results The pressure within the carpal tunnel decreased after BJA in all patients. There were 3 patients with stage II arthritis, 15 patients with stage III arthritis, and 10 patients with stage IV arthritis. The mean pressure prior to BJA among all patients was 23.9 mmHg and decreased to 11.0 mmHg after BJA. Patients with concomitant CTS had a mean pre-BJA pressure of 26.5 mmHg, which decreased to 7.3 mmHg after BJA. Conclusions BJA decompresses the carpal tunnel and decreases the pressure within. In patients with concomitant CTS, the BJA alone (without additional release of the transverse carpal ligament) decreases the carpal tunnel pressure. Further study is warranted to determine the need for discrete release of the transverse carpal ligament in patients with CTS who are undergoing BJA. Level of Evidence Level II, diagnostic.
Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
Authors: Oliver‐Williams Clare T. , Steer Philip J. 
Published: March 2015

AbstractObjectiveTo assess the relationship between race and spontaneous abortion, whether the relationship varies by risk factors, and the effect of spontaneous abortions on subsequent pregnancies.MethodsA retrospective study was undertaken using data collected in London, UK, between 1988 and 2000. Logistic regression evaluated histories of spontaneous abortion and associations with small‐for‐gestational‐age and preterm births in black African, black Caribbean, and South Asian women relative to white European women. Interactions with risk factors were assessed.ResultsOverall, 196 040 women were included. Compared with white Europeans, the odds of a previous spontaneous abortion were increased in black African (adjusted odds ratio [aOR] 1.20; 95% confidence interval [CI] 1.12–1.29) and black Caribbean women (aOR 1.31; 95% CI 1.21–1.41). The strength of the association with black African race increased with age (P = 0.002), and the association with South Asian race increased with age and body mass index (P < 0.001 for both). Spontaneous abortion was associated with preterm birth in all races, but was strongest in black African women (aOR 1.47; 95% CI 1.29–1.67).ConclusionThe greater incidence of spontaneous abortion in black African and black Caribbean women should prompt further study of risk factors in relation to race. The interaction with age in black African and South Asian women could be important for counseling in relation to timing of pregnancy.
Postcrania of juvenilePinacosaurus grangeri(Ornithischia: Ankylosauria) from the Upper Cretaceous Alagteeg Formation, Alag Teeg, Mongolia: implications for ontogenetic allometry in ankylosaurs
Authors: Burns Michael E. , Tumanova Tatiana A. , Currie Philip J. 
Published: March 2015

AbstractThe ankylosaurinePinacosaurusis one of the best known ankylosaur to date in terms of the number and preservational quality of specimens. Juvenile to sub-adult postcrania collected by the Soviet-Mongolian Paleontological Expedition from the Upper Cretaceous Alagteeg Formation at Alag Teeg, Mongolia can be assigned toPinacosaurus grangeribased on discrete cranial characters. One individual is significantly larger than the others and demonstrates delayed fusion of postcranial elements with the earliest occurring between dorsal ribs and vertebrae. The robustness of forelimb elements is positively allometric with respect to their length, indicating weight-bearing relationship. Such length-dependent correlations are not seen in the hind limbs. Finally, incipient cervical half rings suggest a developmental pathway of outgrowths from the underlying band combined with fusion of overlying osteoderms.
Wenlock and Pridoli (Silurian) crinoids from Saaremaa, western Estonia (Phylum Echinodermata)
Authors: Ausich William I. , Wilson Mark A. , Vinn Olev 
Published: March 2015

AbstractStudy of new collections of the Wenlock and Pridoli, Silurian, crinoids from Saaremaa, western Estonia, result in taxonomic revision, expanded ranges, and new taxa. Eucalyptocrinites regularis and Periechocrinus laevis are recognized outside of Sweden for the first time. Desmidocrinus laevigatus Ausich et al., 2012 is reassigned to Methabocrinus. Because the type species of Methabocrinus was previously known only from glacial sediments, the age and provenance of this genus are constrained for the first time. A new crotalocrinitid, Velocrinus coniculus new genus and species, is described. Although the Pridoli faunas of western Estonia contain only twelve species-level taxa assigned to nine genera, this fauna is one of the four richest Pridoli faunas known.
Maternal PUFA status and offspring allergic diseases up to the age of 18 months
Authors: Yu Ya-Mei , Chan Yiong-Huak , Calder Philip C. , Hardjojo Antony , Soh Shu-E , Lim Ai Lin , Fisk Helena L. , Teoh Oon Hoe , Goh Anne , Saw Seang-Mei , Kwek Kenneth , Gluckman Peter D. , Godfrey Keith M. , Chong Yap-Seng , Shek Lynette Pei-Chi , Pan An , Chong Mary Foong Fong , van Bever Hugo P. S. 
Published: March 2015

Studies have suggested that maternal PUFA status during pregnancy may influence early childhood allergic diseases, although findings are inconsistent. We examined the relationship between maternal PUFA status and risk of allergic diseases in early childhood in an Asian cohort. Maternal plasma samples from the Growing Up in Singapore Towards Healthy Outcomes mother–offspring cohort were assayed at 26–28 weeks of gestation for relative abundance of PUFA. Offspring (n 960) were followed up from 3 weeks to 18 months of age, and clinical outcomes of potential allergic diseases (rhinitis, eczema and wheezing) were assessed by repeated questionnaires. Skin prick testing (SPT) was also performed at the age of 18 months. Any allergic disease with positive SPT was defined as having any one of the clinical outcomes plus a positive SPT. The prevalence of a positive SPT, rhinitis, eczema, wheezing and any allergic disease with positive SPT was 14·1 % (103/728), 26·5 % (214/808), 17·6 % (147/833), 10·9 % (94/859) and 9·4 % (62/657), respectively. After adjustment for confounders, maternal total n-3, n-6 PUFA status and the n-6:n-3 PUFA ratio were not significantly associated with offspring rhinitis, eczema, wheezing, a positive SPT and having any allergic disease with positive SPT in the offspring (P>0·01 for all). A weak trend of higher maternal n-3 PUFA being associated with higher risk of allergic diseases with positive SPT in offspring was observed. These findings do not support the hypothesis that the risk of early childhood allergic diseases is modified by variation in maternal n-3 and n-6 PUFA status during pregnancy in an Asian population.
Unequal Access to College in China: How Far Have Poor, Rural Students Been Left Behind?
Authors: Li Hongbin , Loyalka Prashant , Rozelle Scott , Wu Binzhen , Xie Jieyu 
Published: March 2015

AbstractIn the 1990s, rural youth from poor counties in China had limited access to college. After mass college expansion started in 1998, however, it was unclear whether rural youth from poor counties would gain greater access. The aim of this paper is to examine the gap in college and elite college access between rural youth from poor counties and other students after expansion. We estimate the gaps in access by using data on all students who took the college entrance exam in 2003. Our results show that gaps in access remained high even after expansion. Rural youth from poor counties were seven and 11 times less likely to access any college and elite Project 211 colleges than urban youth, respectively. Much larger gaps existed for disadvantaged subgroups (female or ethnic minority) of rural youth from poor counties. We also find that the gaps in college access were mainly driven by rural–urban differences rather than differences between poor and non-poor counties within rural or urban areas.
A Brief Political History of South Australian Agriculture
Authors: FIELKE SIMON J. , BARDSLEY DOUGLAS K. 
Published: March 2015

Abstract:This paper aims to explain why South Australian agricultural land use is focused on continually increasing productivity, when the majority of produce is exported, at the long-term expense of agriculturally-based communities and the environment. A historical analysis of literature relevant to the agricultural development of South Australia is used chronologically to report aspects of the industry that continue to cause concerns in the present day. The historically dominant capitalist socio-economic system and ‘anthropocentric’ world views of farmers, politicians, and key stakeholders have resulted in detrimental social, environmental and political outcomes. Although recognition of the environmental impacts of agricultural land use has increased dramatically since the 1980s, conventional productivist, export oriented farming still dominates the South Australian landscape. A combination of market oriented initiatives and concerned producers are, however, contributing to increasing the recognition of the environmental and social outcomes of agricultural practice and it is argued here that South Australia has the opportunity to value multifunctional land use more explicitly via innovative policy.
The Wolf in the Landscape: Antonio Cesena and Attitudes to Wolves in Sixteenth-Century Liguria
Authors: HEARN ROBERT , BALZARETTI ROSS , WATKINS CHARLES 
Published: March 2015

Abstract:The recent reappearance of wolves in many areas of Europe has stimulated an interest in the past relationships between the species and humans in various different geographical locations and historical epochs. The image of wolves approaching and entering human settlements is a potent image of the wild, ‘natural’ world encroaching on that of the domestic and ‘cultural’. This paper examines the existence of the wolf in the psychological and physical landscape through a micro-historical analysis of a vernacular manuscript from the mid sixteenth century in north-west Italy. The paper demonstrates that the wolf existed both as a ‘mythological beast’ and as a ‘biological animal’ that was a normal, frequently encountered component of the Ligurian faunal assemblage.
Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo
Authors: Wilms Christian D. , Häusser Michael 
Published: March 2015

AbstractThe spatiotemporal pattern of synaptic inputs to the dendritic tree is crucial for synaptic integration and plasticity. However, it is not known if input patterns driven by sensory stimuli are structured or random. Here we investigate the spatial patterning of synaptic inputs by directly monitoring presynaptic activity in the intact mouse brain on the micron scale. Using in vivo calcium imaging of multiple neighbouring cerebellar parallel fibre axons, we find evidence for clustered patterns of axonal activity during sensory processing. The clustered parallel fibre input we observe is ideally suited for driving dendritic spikes, postsynaptic calcium signalling, and synaptic plasticity in downstream Purkinje cells, and is thus likely to be a major feature of cerebellar function during sensory processing.
High dissolved organic carbon release by benthic cyanobacterial mats in a Caribbean reef ecosystem
Authors: Brocke Hannah J. , Wenzhoefer Frank , de Beer Dirk , Mueller Benjamin , van Duyl Fleur C. , Nugues Maggy M. 
Published: March 2015

AbstractBenthic cyanobacterial mats (BCMs) are increasing in abundance on coral reefs worldwide. However, their impacts on biogeochemical cycling in the surrounding water and sediment are virtually unknown. By measuring chemical fluxes in benthic chambers placed over sediment covered by BCMs and sediment with BCMs removed on coral reefs in Curaçao, Southern Caribbean, we found that sediment covered by BCMs released 1.4 and 3.5 mmol C m−2 h−1 of dissolved organic carbon (DOC) during day and night, respectively. Conversely, sediment with BCMs removed took up DOC, with day and night uptake rates of 0.9 and 0.6 mmol C m−2 h−1. DOC release by BCMs was higher than reported rates for benthic algae (turf and macroalgae) and was estimated to represent 79% of the total DOC released over a 24 h diel cycle at our study site. The high nocturnal release of DOC by BCMs is most likely the result of anaerobic metabolism and degradation processes, as shown by high respiration rates at the mat surface during nighttime. We conclude that BCMs are significant sources of DOC. Their increased abundance on coral reefs will lead to increased DOC release into the water column, which is likely to have negative implications for reef health.