bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pressure‐Controlled Electronic and Structural Phase Transitions in Thermoelectric Snse Revealed by Ultrafast Optical Spectroscopy
Authors: Han Yadong , Yang Yunfan , Du Rongxiao , Liu Lei , Fu Juntao , Yu Junhong , Zhang Hang , Hu Jianbo 
Published: February 2025

AbstractHigh‐pressure engineering presents a promising avenue to enhance the thermoelectric property of SnSe, but the behaviors of electronic/lattice systems under pressure, as well as their connections to the thermoelectric performance, remain poorly understood. This study employs in situ high‐pressure ultrafast optical pump‐probe spectroscopy to investigate the nonequilibrium dynamics of both Fermi and bosonic particles in SnSe. These results reveal an electronic structure phase transition (EPT) occurring in the low‐pressure region, alongside a structural phase transition (SPT) at higher pressures. Notably, at 4 GPa, anomalous behaviors of inter‐valley and intra‐valley scattering processes are observed, which band structure calculations attribute to a pressure‐induced abrupt change in electronic structure, identified as a Lifshitz transition. At 7 GPa, the evolution of electron‐phonon scattering lifetime and phonon frequency indicates a structural phase transition from Pnma to Bbmm. These insights into nonequilibrium behaviors of SnSe under high pressure provide a foundational understanding for further optimizing its thermoelectric efficiency.
Single‐Atom W Anchored Hexagonal Boron Nitride Piezoelectric Nanosonosensitizer Remodels Tumor Microenvironment for Enhanced Sonodynamic Therapy
Authors: Deng Hairui , Li Xianan , Pan Lingfeng , Tang Mengcheng , Song Pengyuan , Long Binghua , Sun Xu , Li Yao , Zhang Han , Wang Shibo , Wang Zhaojie , Kong Xiangdong 
Published: February 2025

AbstractSonodynamic therapy (SDT) is a non‐invasive, non‐toxic technique that shows strong potential for tumor treatment: however, its application is limited by a lack of efficient sonosensitizers, insufficient oxygen supply, and high levels of glutathione (GSH) in tumors. In this study, a nanosonosensitizer, single‐atom W anchored hexagonal boron nitride@ferrihydrite@trisulfide bond‐modified carboxymethyl chitosan (W‐BN@Fht@TSCM) nanocomplex, is developed that exhibits an efficient sonosensitizing effect and tumor microenvironment remodeling ability, thereby enhancing SDT. W‐BN is prepared by anchoring monatomic W onto the surface of hexagonal boron nitride (h‐BN) nanosheets, which exhibit a superior piezoelectric response to that of h‐BN owing to the breaking of lattice symmetry. This excellent piezoelectric response facilitates the production of more reactive oxygen species under ultrasound conditions. Moreover, H2O2 in the tumor microenvironment is decomposed to O2 by Fht nanoparticles, which serve as catalase‐like nanoenzymes, thereby alleviating hypoxia and providing sufficient substrates. Additionally, TSCM, which provides three unique redox sites and exhibits a high redox potential, rapidly and efficiently consumes GSH, weakens the antioxidant defense mechanism of tumor cells and enhances the efficacy of SDT. Improving the piezoelectric response of the material while remodeling the tumor microenvironment demonstrates strong therapeutic effects and provides a reference for the design of SDT nanosystems.
Naphthalimide‐Conjugated Spiropyran: Dual‐State Emission and Photo‐Responsive Dynamic Fluorescence Color for Information Encryption Application
Authors: Hu Xiaofang , Fang Bing , Li Pengyu , Wang Junxiao , Li Jie , Dai Yuhua , Yin Meizhen 
Published: February 2025

AbstractDeveloping photo‐switch molecules that show fluorescence in both monomeric and aggregated states, with light‐controllable fluorescence wavelength is far‐reaching and a great challenge. Spiropyran (SP) has received considerable attention in this field. Herein, by conjugating naphthalimide to the indole moiety of SP, a new spiropyran derivative, named NMI‐SP is obtained. NMI‐SP shows dual‐state emission with excellent fluorescence in both its monomeric and aggregated states, attributed to the intramolecular charge transfer character. Moreover, NMI‐SP demonstrates obvious photochromic behavior, accompanied by the visible color change from yellow to green in THF solution, and photo‐responsive fluorescence color change from orange to red in the aggregated state. This work provides new insights into the design of photo‐responsive materials based on SP fluorophore and highlights their potential applications in digital coding and information conversion.
Graded Hydroxyapatite Triply Periodic Minimal Surface Structures for Bone Tissue Engineering Applications
Authors: Koushik Tejas M. , Miller Catherine M. , Antunes Elsa 
Published: February 2025

AbstractPorous scaffolds in bone tissue engineering (BTE) play a crucial role in facilitating osteointegration with host tissues and providing nutrients to cells involved in bone healing. Scaffold architecture influences osteointegration, biofunctionality and mechanical strength, necessitating a clear understanding of its impact. In this study, hydroxyapatite scaffolds are 3D printed with three types of triply periodic minimal surface (TPMS) structures: gyroid, lidinoid, and split‐P, at porosities ranging from 50% to 80%. Split‐P architecture exhibits the highest compression strength, between 15 and 25 MPa, but provides the least surface area for bone apatite precipitation. Conversely, gyroid and lidinoid structures demonstrate the highest levels of bone apatite precipitation across all porosities when immersed in simulated body fluid. To optimise scaffold design, graded structures were designed with multiple TPMS structures arranged in a core‐shell configuration. A structure featuring a solid core and a 70% gyroid shell achieves the highest compression strength of 120 MPa, while also supporting cell attachment and differentiation comparable to that of a fully porous structure. This combination of compression strength similar to cancellous bone and ability for positive interaction with osteoblast cells makes it an ideal candidate for load‐bearing applications in BTE.
Pincer‐Type Pt(II)‐NHC Antibody‐Drug Conjugate for HER‐2‐Targeted Chemoimmunotherapy
Authors: Huang Tao , Huang Wan‐Qiong , Huang Gui‐Feng , Wei Xiao‐Long , Huang Yong‐Liang , Liu Tao , Liu Yungen , Ni Wen‐Xiu , Che Chi‐Ming 
Published: February 2025

AbstractPlatinum‐based chemotherapy drugs play an indispensable role in clinical cancer treatment, but exhibit considerable side effects due to their non‐specific mechanism of killing cancer cells and normal cells. In this regard, the use of antibodies conjugated to anti‐cancer platinum complexes will enable better differentiation of cancer cells from normal cells. Here, six pincer‐platinum(II) NHC (N‐heterocyclic carbene) complexes are reported, one of which has an amino group on the N‐alkyl group of the NHC ligand. This platinum(II) complex is used as the payload for platinum(II)‐based antibody‐drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER‐2). Notably, this ADC can specifically bind to the HER‐2 antigen, distinguish target cells from non‐target cells, and exhibit good anti‐tumor activity in vitro and in vivo.
Hypoxia‐Activated Liposomes Enable Synergistic Photodynamic Therapy for Oral Cancer
Authors: Chen Jiaxuan , Xu Xiaodi , Wang Kexuan , Xue Mingxia , Wang Qing , Zhong Weixiang , Wan Yan , Liu Xiaoyang , Zheng Junnian , Gao Ge , Wang Gang 
Published: February 2025

AbstractOral cancer is a significant public health problem, which is one of the most common malignancy with high mortality in the world. Apart from surgery, photodynamic therapy (PDT) is perceived as another capable method for the treatment of oral cancer. However, limited oxygen content of tumor microenvironment decreased the efficiency of current PDT. Hence, a complementary tumor‐killing system is developed to overcome PDT‐induced oxygen depletion by introducing hypoxia‐activated chemotherapy drugs into tumor‐targeting liposomes. First, liposomes derived from red blood cell (RBC) membrane are decorated with tumor‐targeting formic acid (FA) and designed to carrying photosensitizer TPP and the hypoxia‐activated drug TPZ (TPZ/TPP@RBC‐FA). Laser irradiation on tumor initiated the discharge of chemotherapeutic drugs (TPZ) from TPZ/TPP@RBC‐FA liposomes by increasing the reactive oxygen species, causing the aggravated intratumoral hypoxia and the further generation of the toxic TPZ radicals. The combination of hypoxia‐activated chemotherapy and photodynamic therapy will not only induced efficient cell apoptosis but also caused immunogenic cell death and immunocyte activation. The strategy of loading drugs into liposomes also demonstrated acceptable biosafety. It is believed that the strategy of combining of photodynamic therapy and hypoxia‐activated chemotherapy with liposomes can be implemented for the oral cancer treatment in the near future.
A Universal Thick Anode for Aqueous and Seawater Energy Storage Devices
Authors: Xu Zhixiao , Li Pengcheng , Zhao Jianbao , Hu Ke , Jia Wenting , Gasilov Sergey , Li Ge , Wang Xiaolei 
Published: February 2025

AbstractAqueous and seawater energy storage devices hold great potential for electrical grids application due to safety, affordability, and sustainability. However, their broader deployment has been constrained by the absence of a durable thick anode. Here, the first universal thick anode operating stably across 15 simple‐ion and 3 complex‐ion systems, including nonmetallic (H+, NH4
+), monovalent (Li+, Na+, K+), multivalent ions (Zn2+, Ca2+, Mg2+, Al3+), and seawater ions (>5 cations) is reported. Composed of polymer nanosheets and carbon nanotubes, this anode supports thick electrode fabrication (e.g., 100 mg cm−2 and 1 mm) with low porosity/tortuosity, superior electrical conductivity, mechanical robustness, and chemical stability. Consequently, it achieves exceptionable cycle life (up to 380 000 cycles) in supercapacitors and ultrahigh areal capacities (6.5 mAh cm−2) in batteries, even under practical/extreme conditions, attributed to the formation of a water‐scarce, cation‐rich electrical double‐layer structure, as revealed by simulations. Compatible with sea salt‐based electrolytes and paired with a metal‐free cathode, the anode enables seawater batteries with thousands‐cycle life and high energy/power density. Of universal ion storage, ultrahigh‐loading capability, unlimited resources, and cost‐effectiveness, this polymer electrode is promising for practical aqueous (seawater) energy devices.
Stabilizing Semi‐Interpenetrated Alginate/Pedot Hydrogels via Glyoxal‐Mediated Covalent Crosslinks for Water Steam Generation
Authors: Colombi Samuele , Mingot Julia , Morgado Jorge , Pérez‐Madrigal Maria M. , García‐Torres José , Armelin Elaine , Alemán Carlos 
Published: February 2025

AbstractThe chemical and physical stability of bio‐hydrogels are of utmost interest to avoid the premature degradation of the polymer and to favor cyclic material operations (i.e., material recovery and re‐using). In this work, the stability of different alginate hydrogels semi‐interpenetrated with poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate conducting polymer (Alg/PEDOT), which acts as a photothermal absorber is examined. More specifically, the behavior of Alg/PEDOT hydrogels ionically and covalently crosslinked with Ca2+ ions and glyoxal, respectively, has been compared when used as water purification platforms. The homogenous porosity and higher cycling capacity of the glyoxal‐crosslinked gels provide superior performance for water‐steam generation under sunlight irradiation than that of the ionically stabilized gel. Furthermore, increasing the glyoxal cross‐linking reaction time prove to have little effect on the porosity and the efficiency of freshwater supply from an artificial seawater solution. Covalent cross‐links provide thermal absorber (PEDOT:PSS) retention capacity in artificial seawater, which is critical to maintaining such efficiency with the increasing number of purification cycles. This research opens new frontiers to promote the use of alginate biopolymer in chemical engineering processes such as water desalination, directly addressing the United Nations Sustainable Development Goals for Clean Water & Life on Land.
Optimized EVA Decomposition in Bifacial Solar Panels: Sustainable Recovery of Polymerized Oil and Materials
Authors: Sulkan Chitra , Kumar Thakur Prashant , Sharma Shailza , Das Neeraj 
Published: February 2025

AbstractThe disposal of end‐of‐life (EOL) photovoltaic (PV) solar panels presents environmental challenges due to hazardous materials and complex structure. This study proposes an optimized method for recycling bifacial solar panels, which lack a back sheet and use ethylene‐vinyl acetate (EVA) as the sole encapsulant. The process achieves 100% recovery of valuable materials, including polymerized oil, clean glass, solar cells, and copper tape. Unlike traditional PV panels with back sheet polymers like PVF, PET, or PVDF, bifacial panels simplify the recycling process. EVA, composed of hydrogen, carbon, and oxygen, is more environmentally friendly, especially without fluorinated compounds. Using a modified pyrolysis reactor, the EVA layer is degraded in inert conditions, minimizing emissions and producing polymerized oil. This oil can be used as a lubricant, while the recovered glass, solar cells, and copper tape are reusable in manufacturing new panels. Optimized oil yield is achieved using Response Surface Methodology (RSM) and Box‐Behnken Design (BBD). At a heating rate of 8.92 °C min−1, a 31.82‐min hold time, and a maximum temperature of 528.22 °C, the process yields 57.53% polymerized oil. The oil is characterized by thermogravimetric analysis (TGA) and Fourier‐transform infrared spectroscopy (FT‐IR), meeting ASTM and Australian diesel standards. This method maximizes material recovery and supports a circular economy, enhancing solar energy system sustainability.
Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway
Authors: Liu Xue , Liu Xing , Liu Yunpeng , Long Anxiong , Liu Wei , Sun Shiyun , Lu Shuaibing , Wu Xianxian , Jia Xiaodi , Jose Pedro A , Wei Qiang , Jiang Xiaoliang , Zhang Haizeng , Yang Zhiwei 
Published: February 2025

AbstractThe Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in the development of type 2 diabetes (T2D). Intestinal epithelial cell‐specific Cckbr knockout mice and control wild‐type mice are fed normal diet (ND, 10% fat) or high fat diet (HFD, 60% fat) to study the effect of intestinal Gastrin/CCKBR on blood glucose levels. Gastrin‐SiO2 microspheres (20 mg kg−1 d−1) are designed so that gastrin specifically stimulates intestinal CCKBR, without its absorption into the circulation. Mice with silenced intestinal Cckbr has pre‐diabetes mellitus (Pre‐DM) that rapidly progressed into T2D when fed HFD. Moreover, Gastrin‐SiO2 microspheres markedly reduce glucose absorption in duodenum obtained from patients with T2D. In mice with HFD‐induced T2D, Gastrin‐SiO2 microspheres reduce intestinal glucose absorption by down‐regulating intestinal SGLT1 and GLUT2 expressions and stimulating incretin secretion. This study shows the important role of intestinal Gastrin/CCKBR in intestinal glucose absorption. Gastrin‐SiO2 microspheres may be a promising strategy for the treatment of patients with T2D.
Nanomedicine Penetrating Blood‐Pancreas Barrier for Effective Treatment of Acute Pancreatitis
Authors: Wang Dan , Wang Shuya , Liu Jinjin , Shi Xiaojing , Xiong Tingli , Li Ruishi , Wei Wei , Ji Liandong , Huang Qiong , Gong Xuejun , Ai Kelong 
Published: February 2025

AbstractAcute pancreatitis (AP) is a primary contributor to hospitalization and in‐hospital mortality worldwide. Targeted elimination of mitochondrial reactive oxygen species (mtROS) within pancreatic acinar cells (PACs) represents an ideal strategy for treating AP. However, existing drugs fail to overcome the physiological barriers of the pancreas to effectively reach PACs mitochondria due to the trade‐off between conventional positively charged mitochondrial‐targeting groups and their inability to penetrate the blood‐pancreas barrier (BPB). Here, a tungsten‐based heteropolyacid nano‐antioxidant (mTWNDs) is introduced, co‐modified with tannic acid (TA) and melanin, enabling site‐specific clearance of mtROS in PACs, offering a highly effective treatment for AP. TA exhibits a strong affinity for proline‐rich type III collagen and the mitochondrial outer membrane protein TOM20. This unique property allows mTWNDs to traverse the damaged BPB‐exposing type III collagen to reach PACs and subsequently penetrate mitochondria for targeted mtROS elimination. In cerulein‐induced AP mice, mTWNDs reversed AP at 1/50th the dose of N‐acetylcysteine, suppressing PACs apoptosis and inflammation by blocking the stimulator of the interferon genes pathway activation in macrophage. This study establishes a mitochondrial‐targeting antioxidant nanomedicine strategy for AP treatment.
Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas
Authors: Kim Jinjoo , Zhang Zefu , Albadawi Hassan , Keum Hyeongseop , Mayer Joseph L. , Graf Erin H. , Oklu Rahmi 
Published: February 2025

AbstractEnterocutaneous fistulas (ECF) are challenging to treat contributing to high morbidity and high mortality rates, significantly impacting the quality of life of the patients. Its susceptibility to antibiotic‐resistant infections often leads to chronic inflammation, complicating treatment with conventional methods. Here, 18NC75‐10P‐1IL is reported, which is a multi‐functional shear‐thinning hydrogel comprised of gelatin and nanosilicates for injectability, an ionic liquid for bactericidal effects, and platelet rich fibrin fraction for pro‐healing properties; this biomaterial is engineered for the treatment of ECFs. Through rigorous testing, the mechanical properties of 18NC75‐10P‐1IL were tailored for catheter injection to achieve durable occlusion of fistulous tracts under external pressures simulating clinical scenarios. 18NC75‐10P‐1IL demonstrated pro‐healing effects and anti‐microbial activity against highly resistant patient‐derived bacteria known to be associated with ECF. Subcutaneous implantation and anorectal fistula models confirmed its biocompatibility, pro‐healing, anti‐inflammatory, and anti‐microbial properties compared to control materials, suggesting promising potential for clinical translation in the treatment of human ECFs.
Hybrid Outer Membrane Vesicles with Genetically Engineering for Treatment of Implant‐Associated Infections and Relapse Prevention Through Host Immunomodulation
Authors: Wang Zhichao , Li Mingfei , Li Wenshuai , He Liuliang , Wang Long , Cai Kehan , Zhao Xiao , Chen Yazhou , Li Daifeng 
Published: February 2025

AbstractImplant‐associated infections (IAIs) are refractory to elimination, and the local immunosuppressive microenvironment (IME) exacerbates therapeutic difficulties, ultimately causing persistence and relapse. Therefore, exploring immunostrengthening treatments holds great promise for reversing IME and thoroughly eradicating chronic or repetitive infections. Bacterial outer membrane vesicles (OMVs) have emerged as potential immunostimulatory candidates; however, they lack active targeting capabilities and cause non‐specific inflammatory side effects. In this study, bone marrow‐derived mesenchymal stem cells (BMSCs) are genetically engineered to overexpress CXCR4 and isolated cell membranes (mBMSCCXCR4) for hybridization with OMVs derived from Escherichia coli (E. coli) to produce nanovesicles (mBMSCCXCR4@OMV). The resulting mBMSCCXCR4@OMV nanovesicles demonstrate excellent bone marrow targeting capability and are effectively taken up by bone marrow‐derived macrophages, triggering the efficient transition to pro‐inflammatory M1 status through TLR/NF‐κB pathway. This alteration promotes innate bactericidal capacity and antigen presentation. Subsequent activation of T and B cells and inhibition of myeloid‐derived suppressor cells (MDSCs) facilitated in vivo adaptive immunity in mouse models. Additionally, mBMSCCXCR4@OMV boosted memory B cell and bacteria‐specific antibody responses. Together, these data highlight the potential of mBMSCCXCR4@OMV to eradicate complicated IAIs and provide whole‐stage protection against postsurgical relapse, thus marking a significant immunotherapeutic advancement in the post‐antibiotic era.
Analysis of the spatial distribution and association of banana wilt (Fusarium oxysporum f. sp. cubense) with biophysical factors in Gamo zone, southern Ethiopia
Authors: Bekeko Zelalem , Kedir Biruk , Fininsa Chemeda 
Published: February 2025

AbstractBanana wilt, caused by Fusarium oxysporum f. sp. cubense (Foc), is one of the most important diseases of banana (Musa L.) worldwide including Ethiopia. Foc is responsible for sever yield losses of up to 90% in commercial and local banana cultivars planted in southern Ethiopia. However, there is limited research information about its epidemiology, distribution, and relative importance of the disease in the country particularly in Gamo zone, southern Ethiopia, where banana is dominantly grown. Hence, this study was conducted to investigate and analyze the distribution, importance, and intensity of the disease and its association with biophysical factors. Fields surveys were conducted in three major banana‐growing districts of Gamo zone in Arba Minch Zuria, Mirab Abaya, and Daramalo during the 2019/2020 cropping season in which a total of 90 fields were surveyed. The association of the disease incidence and severity with independent variables was analyzed using a logistic regression model in SAS under the GENMOD procedures. The results of the survey study indicated that Fusarium wilt was widely distributed all the three districts, regardless of agro‐ecological factors. The highest mean incidence (47.37%) and severity (46.31%) values were recorded at Daramalo, while the lowest incidence (20.75%) and severity (28.63%) values were recorded from Arba Minch Zuria district. Variables such as banana cultivars, age of plantations, weeding practices, and disease management methods were significantly associated with the incidence and severity of the disease. The use of improved cultivars reduced disease incidence by 43.60% and the severity by 30.10%, compared to that of local ones. Regression analysis of the biophysical factors with Fusarium wilt severity implied the necessity of effective and feasible integrated management options to be developed against the disease and as well as the importance of awareness raising with all stakeholders regarding its distribution, importance, and possible management options such as the usage of Foc‐resistant varieties in the study area.