bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical and chemical properties and sensory evaluation of camel meat and new camel meat jerky
Authors: Wu Jindi , He Xige , Yun Xueyan , Qi Mei , Menghe Buren , Chen Lu , Han Yunfei , Huang Yajuan , Wang Mingxu , Sha Rina , Borjigin Gerelt 
Published: August 2024

AbstractAlxa Bactrian camel meat is an organic diet that provides balanced nutrition and is easy to digest and absorb. Despite its potential, it is currently underutilized. To develop a new type of camel jerky, this study utilized a single‐factor design method to optimize the formula and fermentation process parameters of Alxa Bactrian camel jerky. Additionally, the physical and chemical composition, nutritional components, protein degradation, and microbial changes of the camel jerky were analyzed to evaluate the nutritional benefits of the new camel jerky created using modern fermentation technology. The results show that the optimal addition amounts of camel fermented jerky ingredients are 2.2% black pepper, 3% salt, 1.8% white sugar, and 9% cooking wine, whereas the optimal fermentation conditions by compound starter culture are 0.07% starter, 23 h of fermentation time, and a 30°C fermentation temperature. Compared to the single starter, the compound starter significantly increased the protein content, total amino acids, unsaturated fatty acids, trace elements, and a*, L*, and e‐values of jerky; however, it also decreased the water activity (aw), thiobarbituric acid, and pH values of jerky during storage. Compound starter strains can compensate for the shortage of single starters and improve the overall quality of meat products. These findings could provide new insights and serve as a reference for the development of camel meat products and hold significant importance for the growth of the camel industry.
Neoadjuvant chemotherapy followed by transoral robotic surgery versus upfront surgery for locoregionally advanced oropharyngeal carcinoma: A propensity score matched analysis
Authors: Sampieri Claudio , Cioccoloni Eleonora , Costantino Andrea , Kim Dahee , Lee Kyuin , Meccariello Giuseppe , Cammaroto Giovanni , Vicini Claudio , Kim Se‐Heon 
Published: August 2024

AbstractBackgroundTransoral robotic surgery (TORS) performed after neoadjuvant chemotherapy (NAC) is a promising treatment for advanced‐stage oropharyngeal carcinoma (OPSCC) able to reduce the adjuvant therapy administration rate.MethodsA retrospective bi‐centric study was conducted to analyze NAC + TORS versus upfront TORS patients. A 1:1 propensity score matching was used to compare the two groups.ResultsAmong the 300 patients with stage III‐IV OPSCC, 204 patients were matched for comparing NAC + TORS versus upfront TORS. Between the two groups, no significant difference was observed in recurrences and in survival for RFS, OS, and DSS. In the NAC + TORS p16‐positive population, adjuvant therapy could be spared in 51% versus 16% in the upfront surgery cohort (p < 0.001) due to the lower frequency of pathological risk factors after NAC.ConclusionsNAC followed by TORS for locoregionally advanced OPSCC demonstrated to achieve non‐inferior survival outcomes to upfront surgery, while in the p16‐positive population allowed to significantly spare adjuvant therapy.
Spillover effects in the nexus of finance‐institutions‐growth: New insights from spatial Durbin analysis on emerging economies
Authors: Ahmad Mahyudin , Hall Stephen G. , Law Siong Hook , Nayan Sabri 
Published: August 2024

AbstractDespite extensive finance‐growth literature, the critical role of spatial interdependence between countries has often been overlooked. This paper addresses this gap by utilising spatial Durbin modelling on a 30‐year panel dataset of 56 emerging economies, examining the spillover effects of financial development (FD) and institutions on economic growth. The findings reveal FD has a significant positive within‐country impact on growth; on average, FD is expected to raise growth by approximately 5.8% holding other factors constant. Meanwhile, the FD spillover effect on growth is estimated to be around 10 times its within‐country effect, which is not surprising given that the 10‐nearest‐neighbour is the preferred matrix for conceptualising the spatial dependence between the countries under study. The results however show no evidence of significant threshold effect of FD. Political institutions emerge as the most influential in driving growth both within and across countries, whereas improvement in economic institutions moderates the growth‐effect of FD. FD's within‐country effect on growth is largely driven by financial institutions, while its spillover effect stems primarily from the neighbours' financial markets. The findings' robustness is confirmed through a battery of tests. In conclusion, this study offers valuable insights into the complex finance‐institutions‐growth nexus in emerging economies. By considering spatial interdependencies and the role of institutions, policymakers can craft effective strategies to harness FD's positive effects and foster an environment for sustained, inclusive economic growth.
The LTAR Cropland Common Experiment in the Upper Chesapeake Bay
Authors: Dell Curtis J. , Karsten H. D. , Laboski C. A. M. , Adams Thomas S. , Goslee Sarah C. , Adler Paul R. 
Published: August 2024

AbstractDairy production is a key agricultural enterprise in the Upper Chesapeake Bay (UCB) basin, where phosphorous (P) and nitrogen (N) loading contribute to eutrophication. Import of forages and grains and application of mineral fertilizers contribute to nutrient imbalances in the basin. The UCB Long‐Term Agroecosystem Research Cropland Common Experiment aims to evaluate diverse crop rotations that minimize the need for imported feed, maximize year‐round living cover, and reduce nutrient losses. UCB's plot‐scale experiment was established in 2018, incorporating an ongoing cropping system study that was established by the Pennsylvania State University in 2010. An alternative dairy cropping rotation (including silage and grain corn [Zea mayes L.], alfalfa [Medicago sativa L.]/orchardgrass [Dactylis glomerata L.] mix, winter rye silage [Secale cereale L.], and sorghum‐sudangrass [Sorghum × drummondii (Steud.) Millsp. & Chas]) that employed manure injection, integrated pest management, and less frequent manure application was compared to a prevailing, conventionally managed silage corn–alfalfa rotation with higher manure application rates. A field‐scale experiment was established in 2019 to monitor alternative production practices (manure injection and avoidance of neonicotinoid seed treatment) and prevailing practices in three fields on a commercial dairy farm. Findings suggest that crop rotation diversification, manure injection, and integrated pest management have the potential to increase the economic and environmental sustainability of dairy cropping systems, but long‐term evaluation is needed for confirmation.
Exploring Creative Spaces Predict Domain‐Specific Creative Achievements
Authors: Goulet‐Pelletier Jean‐Christophe , Cousineau Denis 
Published: August 2024

ABSTRACTThis study aimed to understand the factors predicting creative activities and creative achievements among university students. Based on a recently proposed framework of 10 creative spaces, we hypothesized that exploring those creative spaces, alongside the personality trait openness to experience and divergent thinking abilities would predict creative activities and achievements in specific domains. Using the Inventory of Creative Activities and Achievements (ICAA) to evaluate eight domains of creativity, two divergent thinking tasks, and one associative task, we analyzed a sample of n = 300 university students. The results of Structural Equation Models revealed that the creative spaces significantly predicted creative activities and creative achievements in the eight domains assessed. The model explained in average 27% of the variance in creative activities and 17% in creative achievements. Openness significantly predicted creative activities in music, literature, and arts and crafts. Intellect did not significantly predict any domain. Lastly, fluency in divergent thinking was positively associated with all domains (average coefficient of β = .15), despite not always reaching significance. We discuss the roles of the recently proposed creative spaces, as well as openness to experience, and fluency in predicting creativity across various domains.
Comparing barriers to early stage diagnosis of hepatocellular carcinoma between safety net hospitals and academic medical centers: An analysis from the United States Safety‐Net Collaborative
Authors: Stylianos Sophia L. , Goel Caroline R. , Lee Rachel M. , Yopp Adam , Kronenfeld Joshua , Goel Neha , Datta Jashodeep , Lee Ann , Silberfein Eric , Russell Maria C. ,   and other members of the United States Safety‐Net Collaborative
Published: August 2024

AbstractBackground and ObjectivesEarly detection of hepatocellular carcinoma (HCC) is associated with improved survival. However, a greater proportion of patients treated at safety net hospitals (SNHs) present with late‐stage disease compared to those at academic medical centers (AMCs). This study aims to identify barriers to diagnosis of HCC, highlighting differences between SNHs and AMCs.MethodsThe US Safety Net Collaborative‐HCC database was queried. Patients were stratified by facility of diagnosis (SNH or AMC). Patient demographics and HCC screening rates were examined. The primary outcome was stage at diagnosis (AJCC I/II—“early”; AJCC III/IV—“late”).Results1290 patients were included; 50.2% diagnosed at SNHs and 49.8% at AMCs. At SNHs, 44.4% of patients were diagnosed late, compared to 27.6% at AMCs. On multivariable regression, Black race was associated with late diagnosis in both facilities (SNH: odds ratio 1.96, p = 0.03; AMC: 2.27, <0.01). Screening was associated with decreased odds of late diagnosis (SNH: 0.46, p = 0.04; AMC: 0.37, p < 0.01).ConclusionsBlack race was associated with late diagnosis of HCC, while screening was associated with early diagnosis across institutional types. These results suggest socially constructed racial bias in screening and diagnosis of HCC. Screening efforts targeting SNH patients and Black patients at all facilities are essential to reduce disparities.
Photonic Neuromorphic Pattern Recognition with a Spiking DFB‐SA Laser Subject to Incoherent Optical Injection
Authors: Zhang Yuna , Xiang Shuiying , Yu Chengyang , Gao Shuang , Han Yanan , Guo Xingxing , Zhang Yahui , Shi Yuechun , Hao Yue 
Published: August 2024

AbstractPhotonic neuromorphic computing is a competitive paradigm to overcome the bottleneck of von Neumann architectures. Incoherent and coherent synaptic networks are two popular schemes realizing photonic weighting functions. Previous works have proved the distributed feedback (DFB) laser with an intracavity saturable absorber (DFB‐SA) can behavior like a spiking neuron. However, the compatibility with the incoherent synaptic architecture has not yet been demonstrated. Here the neuron‐like dynamics of a DFB‐SA laser subject to single‐wavelength and multiple‐wavelengths incoherent optical injections are experimentally demonstrated. The results show that, for the DFB‐SA laser subject to single‐wavelength incoherent injection, the neuron‐like dynamics including threshold, temporal integration, and refractory period are achieved. Besides, the range of injection wavelength that leads to a successful neuron‐like response is identified. For the DFB‐SA laser with four‐wavelength incoherent optical injection, the neuron‐like dynamics can also be achieved. In addition, the effect of wavelength interval is also considered. The logic XOR operation and Iris recognition tasks are successfully implemented. Furthermore, the feasibility of a cascaded system for the DFB‐SA lasers with four‐wavelengths incoherent optical injection is demonstrated. This work provides a feasible scheme for the system integration of photonic spiking neurons and incoherent synaptic networks.
CBCT‐based synthetic CT image generation using a diffusion model for CBCT‐guided lung radiotherapy
Authors: Chen Xiaoqian , Qiu Richard L. J. , Peng Junbo , Shelton Joseph W. , Chang Chih‐Wei , Yang Xiaofeng , Kesarwala Aparna H. 
Published: August 2024

AbstractBackgroundAlthough cone beam computed tomography (CBCT) has lower resolution compared to planning CTs (pCT), its lower dose, higher high‐contrast resolution, and shorter scanning time support its widespread use in clinical applications, especially in ensuring accurate patient positioning during the image‐guided radiation therapy (IGRT) process.PurposeWhile CBCT is critical to IGRT, CBCT image quality can be compromised by severe stripe and scattering artifacts. Tumor movement secondary to respiratory motion also decreases CBCT resolution. In order to improve the image quality of CBCT, we propose a Lung Diffusion Model (L‐DM) framework.MethodsOur proposed algorithm is based on a conditional diffusion model trained on pCT and deformed CBCT (dCBCT) image pairs to synthesize lung CT images from dCBCT images and benefit CBCT‐based radiotherapy. dCBCT images were used as the constraint for the L‐DM. The image quality and Hounsfield unit (HU) values of the synthetic CTs (sCT) images generated by the proposed L‐DM were compared to three selected mainstream generation models.ResultsWe verified our model in both an institutional lung cancer dataset and a selected public dataset. Our L‐DM showed significant improvement in the four metrics of mean absolute error (MAE), peak signal‐to‐noise ratio (PSNR), normalized cross‐correlation (NCC), and structural similarity index measure (SSIM). In our institutional dataset, our proposed L‐DM decreased the MAE from 101.47 to 37.87 HU and increased the PSNR from 24.97 to 29.89 dB, the NCC from 0.81 to 0.97, and the SSIM from 0.80 to 0.93. In the public dataset, our proposed L‐DM decreased the MAE from 173.65 to 58.95 HU, while increasing the PSNR, NCC, and SSIM from 13.07 to 24.05 dB, 0.68 to 0.94, and 0.41 to 0.88, respectively.ConclusionsThe proposed L‐DM significantly improved sCT image quality compared to the pre‐correction CBCT and three mainstream generative models. Our model can benefit CBCT‐based IGRT and other potential clinical applications as it increases the HU accuracy and decreases the artifacts from input CBCT images.
Unraveling contributions to the Z‐spectrum signal at 3.5 ppm of human brain tumors
Authors: Heo Hye‐Young , Singh Munendra , Mahmud Sultan Z. , Blair Lindsay , Kamson David Olayinka , Zhou Jinyuan 
Published: August 2024

AbstractPurposeTo evaluate the influence of the confounding factors, direct water saturation (DWS), and magnetization transfer contrast (MTC) effects on measured Z‐spectra and amide proton transfer (APT) contrast in brain tumors.MethodsHigh‐grade glioma patients were scanned using an RF saturation‐encoded 3D MR fingerprinting (MRF) sequence at 3 T. For MRF reconstruction, a recurrent neural network was designed to learn free water and semisolid macromolecule parameter mappings of the underlying multiple tissue properties from saturation‐transfer MRF signals. The DWS spectra and MTC spectra were synthesized by solving Bloch‐McConnell equations and evaluated in brain tumors.ResultsThe dominant contribution to the saturation effect at 3.5 ppm was from DWS and MTC effects, but 25%–33% of the saturated signal in the gadolinium‐enhancing tumor (13%–20% for normal tissue) was due to the APT effect. The APT# signal of the gadolinium‐enhancing tumor was significantly higher than that of the normal‐appearing white matter (10.1% vs. 8.3% at 1 μT and 11.2% vs. 7.8% at 1.5 μT).ConclusionThe RF saturation‐encoded MRF allowed us to separate contributions to the saturation signal at 3.5 ppm in the Z‐spectrum. Although free water and semisolid MTC are the main contributors, significant APT contrast between tumor and normal tissues was observed.
Enhanced mechanical, thermal properties and thermal conductivities of epoxy composites via incorporating graphene oxide‐grafted carbon nanotubes hybrids
Authors: Liu Song , Zhang Jingshan , Fan Xiangying , Hu Linchen , Guan Jun , Zeng Shaohua 
Published: August 2024

AbstractA hetero‐structured hybrid was produced by grafting one‐dimensional (1D) amine‐functionalized multiwalled carbon nanotubes (MWCNTs) onto the basal plane of two‐dimensional (2D) graphene oxide (GO) via an amine‐epoxy ring‐opening reaction, and such hybrid was further applied for reinforcing epoxy composites. Based on this hybrid design, 1D MWCNTs anchored on the 2D GO nanosheets resisted the re‐stacking of GO nanosheets while GO improved the MWCNTs' dispersion state. Attributing to the synergistic effect of GO and MWCNTs, a multi‐dimensional conducting network within epoxy matrix was constructed and efficiently transferred stress and heat between hybrid and matrix. When just 0.5 wt% hybrids were incorporated, the mechanical properties, thermal stability and thermal conductivity of hybrid‐filled epoxy composites were significantly improved, compared with pure epoxies. This work gives a promising method for designing and preparing polymer composites for thermal management and protection applications.Highlights
A hetero‐structured hybrid consisting of MWCNTs and GO was obtained.
Better dispersion of GO–MWCNTs within matrix was achieved.
A multi‐dimensional GO–MWCNTs conducting network in matrix was constructed.
Enhanced properties were due to the synergistic effect of GO and MWCNTs.
Structural performance of GO and MWCNTs was maximized.
Internal consistency of measures for ICD‐11 personality disorder severity and traits: A systematic review and meta‐analysis
Authors: Hualparuca‐Olivera Luis , Caycho‐Rodríguez Tomás , Torales Julio , Ramos‐Vera Cristian , Ramos‐Campos Dayana , Córdova‐Gónzales Luis , Bach Bo 
Published: August 2024

AbstractA number of measures and scales have been developed for the ICD‐11 personality disorder (PD) diagnosis, including severity and trait dimensions. The present systematic review and meta‐analysis sought to evaluate the internal consistency of these measures across different populations and cultures. A systematic search was conducted across four databases where relevant studies were subjected to explicit eligibility criteria resulting in 49 included studies and 370 effect sizes. Study characteristics were tabulated, their methodological quality was evaluated, and findings were synthesized using random effects meta‐analysis. Findings overall indicated that measures of ICD‐11 PD severity and trait domains have adequate levels of internal consistency (α/ω = 0.82, 95% CI [0.81; 0.83], I2 = 97.3%). Aspects such as sample, country, language, format, and measured construct were significant sources of variation. Additional meta‐analyses revealed that some measures performed better than others for certain dimensions. Internal consistency was overall supported across ICD‐11 measures of severity and trait domains. Future research should further investigate the interrater reliability, test–retest reliability and stability, and alignment with interview‐based PD diagnoses.
Integrase inhibitor drugs during pregnancy and congenital anomalies: A case/non‐case study from the global pharmacovigilance database VigiBase®
Authors: Saint‐Lary Laura , Lacroix Isabelle , Leroy Valériane , Sommet Agnès 
Published: August 2024

AbstractIn 2018, a significant neural tube defects (NTD) signal was reported after pre‐conceptional exposure to dolutegravir, but was not confirmed in further analysis. Since 2019, dolutegravir‐based regimen, an integrase inhibitor (INI), is recommended by WHO as the most‐effective first‐line therapy in all patients living with HIV. To explore the potential INI‐related teratogenic effect, we searched disproportionate signals between exposure to INI‐class drugs and congenital anomalies, compared to non‐INI drugs, using the international pharmacovigilance database, VigiBase®. We selected all the reports registered in VigiBase® between 01/01/2007 and 30/03/2021 on any antiretroviral drug‐related fetal or neonatal adverse drug reactions, declared either in children (<2 years) exposed in utero or in pregnant women (12–50 years). A case/non‐case study was conducted to detected signals between congenital anomalies and prenatal exposure to any INI‐class drug, compared to non‐INI drugs, by estimating adjusted reporting odds ratios (aROR) with 95% confidence intervals (95%CI). We identified 2521 unique reports, among which 664 (26.3%) were related to INI‐class use. Overall, 520 congenital anomalies were cited from 327 unique reports, of whom 31.0% were INI‐related. Compared to non‐INI drugs, no significant disproportionate reporting signal between prenatal exposure to INI‐class drugs and congenital anomalies was found (aROR 1.13; 95% CI:0.85–1.51). However, specific significant signals were reported for raltegravir/elvitegravir/dolutegravir drug exposure and urinary malformations (aROR 2.43; 95%CI:1.08–5.43), digestive malformations (aROR 3.09; 95%CI:1.22–7.84), and NTDs (aROR 3.02; 95%CI:1.09–8.37). Although specific congenital anomalies signals associated with raltegravir/elvitegravir/dolutegravir exposure were notified, causal relationship needs to be further investigated in prospective studies.
Occurrence and potential diffusion of pine wilt disease mediated by insect vectors in China under climate change
Authors: Gao Ruihe , Liu Lei , Fan Shiming , Zheng Wenfang , Liu Ruyuan , Zhang Zhiwei , Huang Ruifen , Zhao Lijuan , Shi Juan 
Published: August 2024

AbstractBACKGROUNDPine wilt disease (PWD), a major international quarantined forest pest, causes serious ecological and economic damage to Pinus species in Asia and Europe. In China, PWD has spread northeasterly and northwesterly beyond its original northern limits. Consequently, an evaluation of the insect vector‐mediated occurrence and potential diffusion of PWD is needed to identify important transmission routes and control the spread of disease.RESULTSAn optimized MaxEnt model was used to assess the current and future geographical distribution of Bursaphelenchus xylophilus and its insect vectors in China. The predicted suitable area for B. xylophilus colonization is currently 212.32 × 104 km2 and mainly concentrated in Central, East, Southwest and South China, although is anticipated to include the northwestern regions of China in the future. As for the insect vectors, Monochamus alternatus and M. saltuarius are expected to spread toward the northwest and southwest, respectively. The maximum predicted dispersion area of PWD mediated by M. alternatus, M. saltuarius and both species was 91.85 × 104, 218.76 × 104 and 29.99 × 104 km2, respectively, with potential diffusion areas being anticipated to increase in the future. Both the suitable probabilities and areas of B. xylophilus and its insect vectors were found to vary substantially along the latitudinal gradient, with the latitudinal range of these species being predicted to expand in the future.CONCLUSIONThis is the first study to investigate the potential diffusion areas of PWD mediated by insect vectors in China, and our finding will provide a vital theoretical reference and empirical basis for developing more effective management strategies for the control of PWD in China. © 2024 Society of Chemical Industry.