bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches
Authors: Kooij Viola , Venkatraman Vidya , Kirk Jonathan A. , Ubaida‐Mohien Ceereena , Graham David R. , Faber Matthijs J. , Van Eyk Jennifer E. 
Published: June 2014

PurposeThe identification of protein isoforms in complex biological samples is challenging. We, therefore, used an MS approach to unambiguously identify cardiac myofilament protein isoforms based on the observation of a tryptic peptide consisting of a sequence unique to a particular isoform.Experimental designThree different workflows were used to isolate and fractionate rat cardiac myofilament subproteomes. All fractions were analyzed on an LTQ‐Orbitrap MS, proteins were identified using various search engines (MASCOT, X!Tandem, X!Tandem Kscore, and OMSSA) with results combined via PepArML Meta‐Search engine, and a postsearch analysis was performed by MASPECTRAS. All MS data have been deposited in the ProteomeXchange with identifier PXD000874 (http://proteomecentral.proteomexchange.org/dataset/PXD000874).ResultsThe combination of multiple workflows and search engines resulted in a larger number of nonredundant proteins identified than with individual methods. A total of 102 myofilament annotated proteins were observed overlapping in two or three of the workflows. Literature search for myofilament presence with manual validation of the MS spectra was carried out for unambiguous identification: ten cardiac myofilament and 17 cardiac myofilament‐associated proteins were identified with 39 isoforms and subisoforms.Conclusion and clinical relevanceWe have identified multiple isoforms of myofilament proteins that are present in cardiac tissue using unique tryptic peptides. Changes in distribution of these protein isoforms under pathological conditions could ultimately allow for clinical diagnostics or as therapeutic targets.
Polchinski's equation for group field theory
Authors: Krajewski T. , Toriumi R. 
Published: June 2014

AbstractWe derive an exact renormalization group equation in the context of (colored) group field theories. This equation describes the variation of the effective action as some of the modes of the fields are integrated out. From a combinatorial point of view, the effective action can be expressed using a boundary triangulation and the corresponding renormalization group equation identifies some of its simplexes, image In group field theory, terms in the effective action are parametrized by spin networks, while the group field theory Feynman graphs correspond to spin foams. This provides a formulation of group field theories that only involves boundary graphs.
To What Extent do Neighbouring Populations Affect Local Population Growth Over Time?
Authors: Han Mengjie , Håkansson Johan , Rönnegård Lars 
Published: June 2014

AbstractThis study covers a period when society changed from a pre‐industrial agricultural society to a post‐industrial service‐producing society. Parallel with this social transformation, major population changes took place. In this study, we analyse to what extent local population change is affected by neighbouring populations. To do this, we focused on the last 190 years of local population change that redistributed population in Sweden. We used literature to identify several different processes in the population redistribution. The different processes implied different spatial dependencies between local population change and the surrounding populations. The analysis is based on an unchanged historical parish division, and we used an index of local spatial correlation to describe different types of spatial dependencies that influenced the redistribution of the population. To control inherent time dependencies, we introduced a non‐separable spatial‐temporal correlation model into the analysis of population redistribution. Hereby, several different spatial dependencies could be simultaneously observed over time. The main conclusions are that while local population changes have been highly dependent on neighbouring populations in the 19th century, this spatial dependence became insignificant already when two parishes are separated by 5 km in the late 20th century. It is argued that the only process that significantly redistributed the population at the end of the 20th century is the immigration to Sweden. Copyright © 2014 John Wiley & Sons, Ltd.
Highly Skilled Migrant Workers and the UK Business Cycle
Authors: Vargas‐Silva Carlos 
Published: June 2014

AbstractThis article explores the labour market dynamics of three groups of highly skilled foreign nationals in the UK: non‐European Union (EU), Old EU (i.e. nationals of the other 14 countries that were members of the EU before 2004), and A8 (i.e. countries that joined the EU in 2004 with the exception of Malta and Cyprus). In particular, the article explores the impact of the UK business cycle on the labour market outcomes of these three groups and compares that impact with the one for highly skilled British nationals. Key findings include the following: (1) there is more evidence about the business cycle having an impact on employment and unemployment outcomes for those highly skilled workers who have greater access to the UK labour market and welfare system (i.e. British, Old EU, and A8 nationals); and (2) better economic conditions relate to a higher probability of self‐employment for British nationals and to a lower probability of self‐employment for A8 nationals. Copyright © 2014 John Wiley & Sons, Ltd.
A novel mechanism for anonymizing Global System for Mobile Communications calls using a resource‐based Session Initiation Protocol community network
Authors: Psaroudakis Ioannis , Katos Vasilios , Efraimidis Pavlos S. 
Published: June 2014

AbstractConsidering the widespread adoption of smartphones in mobile communications and the well‐established resource sharing use in the networking community, we present a novel mechanism to achieve anonymity in the Global System for Mobile Communications (GSM). We propose a Voice over Internet Protocol infrastructure using the Session Initiation Protocol (SIP) where a smartphone registers on a SIP registrar and can start GSM conversation through another smartphone acting as a GSM gateway, by using a SIP intermediate without an extra cost. The testbed that we developed for empirical evaluation revealed no significant quality of service degradation. Copyright © 2014 John Wiley & Sons, Ltd.
Time‐interval analysis of ductus venosus flow velocity waveforms in twin‐to‐twin transfusion syndrome treated with laser surgery
Authors: Tachibana D. , Glosemeyer P. , Diehl W. , Nakagawa K. , Wada N. , Kurihara Y. , Fukui M. , Koyama M. , Hecher K. 
Published: June 2014

ABSTRACTObjectivesTo investigate time‐interval variables of ductus venosus (DV) flow velocity waveforms (FVWs) in twin‐to‐twin transfusion syndrome (TTTS), comparing the results with reference ranges from normal singleton fetuses. The impact of laser surgery and the effect of prognostic factors were also evaluated.MethodsIn 107 TTTS cases, DV‐FVWs of both recipients and donors were recorded 1 day before and 2 days after laser therapy. Time intervals for systolic (S) and early diastolic (D) peaks were analyzed retrospectively with regard to acceleration time (acc‐S and acc‐D for S and D, respectively) and deceleration time (dec‐S and dec‐D for S and D, respectively). For each variable, Z‐scores were calculated with respect to previously reported normal reference ranges.ResultsZ‐scores for all variables showed statistically significant differences from those observed previously in normal fetuses, with the exception of dec‐S of donors. The most striking differences were observed in longer dec‐S of recipients (P < 0.001) and longer dec‐D of donors (P < 0.001). Laser therapy showed significant impact on dec‐S and acc‐D in recipients and on all variables in donors. Regarding the short‐term prognosis, acc‐S and dec‐S showed significant differences for the prediction of intrauterine fetal demise in donors (P = 0.009 and P = 0.011, respectively).ConclusionThis study demonstrates that time‐interval variables of DV‐FVWs may differentiate the characteristic hemodynamic changes caused by unbalanced blood volume between recipients and donors. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.
The future of emissions trading
Authors: Meckling Jonas 
Published: June 2014

Over the past 15 years, carbon markets have been set up by private and public actors at various geographic scales and with varying financial scope. The history of the early stage of carbon markets reveals a mixed record: the instrument diffused widely across the globe, while existing carbon markets performed rather slow, though anecdotal evidence suggests positive side effects on climate policymaking. Going forward, three key driving forces are likely to shape the future of emissions trading: (1) the source and sustainability of political demand for climate action in general and carbon markets in particular, (2) the governance of operating carbon markets including questions of bureaucratic capacity and regulatory capture, and (3) the pattern of market globalization, which encompasses issues of carbon price comparability, market linkage, and expansion. Depending on how these driving forces and fault lines play out, a number of scenarios are possible, ranging from strongly embedded and effective carbon markets to their collapse. The trajectory to any one of these scenarios could be characterized by tipping points, which are likely to come about incrementally. WIREs Clim Change 2014, 5:569–576. doi: 10.1002/wcc.293This article is categorized under:

Climate Economics > Economics of Mitigation
The Carbon Economy and Climate Mitigation > Policies, Instruments, Lifestyles, Behavior
Policy and Governance > Multilevel and Transnational Climate Change Governance
Inborn errors of purine metabolism: clinical update and therapies
Authors: Balasubramaniam Shanti , Duley John A. , Christodoulou John 
Published: June 2014

AbstractInborn errors of purine metabolism exhibit broad neurological, immunological, haematological and renal manifestations. Limited awareness of the phenotypic spectrum, the recent descriptions of newer disorders and considerable genetic heterogeneity, have contributed to long diagnostic odysseys for affected individuals. These enzymes are widely but not ubiquitously distributed in human tissues and are crucial for synthesis of essential nucleotides, such as ATP, which form the basis of DNA and RNA, oxidative phosphorylation, signal transduction and a range of molecular synthetic processes. Depletion of nucleotides or accumulation of toxic intermediates contributes to the pathogenesis of these disorders. Maintenance of cellular nucleotides depends on the three aspects of metabolism of purines (and related pyrimidines): de novo synthesis, catabolism and recycling of these metabolites. At present, treatments for the clinically significant defects of the purine pathway are restricted: purine 5′‐nucleotidase deficiency with uridine; familial juvenile hyperuricaemic nephropathy (FJHN), adenine phosphoribosyl transferase (APRT) deficiency, hypoxanthine phosphoribosyl transferase (HPRT) deficiency and phosphoribosyl‐pyrophosphate synthetase superactivity (PRPS) with allopurinol; adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiencies have been treated by bone marrow transplantation (BMT), and ADA deficiency with enzyme replacement with polyethylene glycol (PEG)‐ADA, or erythrocyte‐encapsulated ADA; myeloadenylate deaminase (MADA) and adenylosuccinate lyase (ADSL) deficiencies have had trials of oral ribose; PRPS, HPRT and adenosine kinase (ADK) deficiencies with S‐adenosylmethionine; and molybdenum cofactor deficiency of complementation group A (MOCODA) with cyclic pyranopterin monophosphate (cPMP). In this review we describe the known inborn errors of purine metabolism, their phenotypic presentations, established diagnostic methodology and recognised treatment options.
Interaction of a Novel Anionic Gemini Surfactant Containing a Triazine Ring with Cetyltrimethylammonium Bromide in Aqueous Solution
Authors: Hu Zhiyong , Wang Liqiong , Guo Jianfeng , Cao Duanlin , Chang Jing , Fan Li 
Published: June 2014

AbstractThe interaction between a novel anionic gemini surfactant containing a triazine ring, denoted as C8‐G, and cetyltrimethylammonium bromide (CTAB) has been investigated in aqueous solution. The surface tension vs log. molar concentration plots of the individual surfactants and their mixtures were measured at different temperatures (298, 303, 308, and 313 K) by the drop volume method. The surface properties and the interaction parameters of the adsorption monolayer and the mixed micelle were obtained from the plot. The results showed that the CMC of the C8‐G/CTAB mixture reached a minimum value of 3.20 × 10−5 mol/L when αG (the mole fraction of C8‐G in the mixed system) was 0.7 at 308 K, and the minimum γCMC was 28.1 mN/m obtained for the molar ratio of 0.9 at 308 K. Interaction between the two components was strongest () when αG was 0.7 at 303 K. All the C8‐G/CTAB mixtures exhibited synergism in both surface tension reduction efficiency and mixed micelle formation except when the mole fraction of C8‐G (αG) was 0.1, 0.5 and 0.9 at 313 K, and became greatest for the molar ratio of 0.7 at 303 K. The C8‐G/CTAB mixtures exhibited synergism in surface tension reduction effectiveness for all the complex ratios at 303 K, αG = 0.1, 0.3, 0.9 at 308 K and αG = 0.7 at 313 K, whereas the other surfactant mixtures did not show this synergism.
Catalytic Production of 1‐Octadecanol from Octadecanoic Acid by Hydrotreating in a Plug Flow Reactor
Authors: Potts Thomas M. , Durant Keiron , Hestekin Jamie , Beitle Robert , Ackerson Michael 
Published: June 2014

Abstract1‐Octadecanol (stearic alcohol) has uses ranging from lubricants to perfumes. The production of 1‐octadecanol from octadecanoic acid (stearic acid) was investigated in a liquid‐phase trickle‐bed reactor by hydrogenating octadecanoic acid using a Ni/Co/Mo sulfide catalyst. The primary reactions occurring in the reactor were the desired conversion of octadecanoic acid to 1‐octadecanol and the subsequent undesired conversion of 1‐octadecanol to octadecane. A model was developed to predict these two reactions. The model found to be most useful for this system was a series–parallel reaction first order in octadecanoic acid and 1‐octadecanol and pseudo‐zero order in hydrogen for both reactions. The activation energies of the first and second reactions were 63.7.8 and 45.6 kJ/mol, respectively. From these values, the conversion of octadecanoic acid and the selectivity to the desired product as functions of temperature, space velocity, and inlet octadecanoic acid concentration were estimated. The model predicts the maximum productivity of 1‐octadecanol occurs at higher temperatures with short residence times. Parametric plots show productivity to be ≥0.48 g 1‐octadecanol/g octadecanoic acid at 566 °F and a 0.1 h residence time.
Aresenopyrite–pyrite paragenesis in gold deposits (thermodynamic modeling)
Authors: Vilor N.V. , Kaz’min L.A. , Pavlova L.A. 
Published: June 2014

Abstract
The compositions of parageneses including arsenopyrite (Asp), pyrite (Py), and As-pyrite (As-Py) have been calculated by the solution of primal physicochemical modeling problems. The numerical models for the interaction of Py matrix with hydrothermal solution saturated with Asp are considered for three variants of the solution penetration into the Py matrix: percolation, spreading, and tightening at 100-300 °C and 300 bars. It is shown that Asp forms in the zone of an ore column where fluid (solution) is predominant, with the Py matrix being replaced independently of the type of the solution transfer. Prevailing As and Fe complexes are considered. The calculated models for the three types of interaction show that the redox potential in the solution varies from –0.055 V at the ends of the Asp-containing ore column to –0.55 V in its central zone. This difference makes an electrochemical geochemical barrier at the interface, where metallic gold is deposited with Asp–Py ores.
APSI: a proposed integrative model for suicide prevention
Authors: Kelly J. , Sammon N. , Byrne M. 
Published: June 2014

BackgroundDeaths by suicide have been increasing in recent years in Ireland, many of whom have co-morbid mental health difficulties and/or have attended primary care services 1 month before death.AimsTo profile how ‘Access to Psychological Services Ireland’ (APSI) provides stepped-care therapies for mild-to-moderate adult mental health presentations and the potential effectiveness of this model based on comparison to a review of evidence-based strategies in suicide prevention. A secondary aim is to highlight how APSI has the potential to target those at risk of suicide and provide an integrative after-care service to complement secondary care mental health services.FindingsIn a context of inter-agency working, APSI provides an integrated continuum of suicide prevention interventions that map onto or intervene across the continuum of suicide behaviour. Hence, APSI appears to implement what the literature suggests will work in preventing suicide. However, outcome research is needed to establish APSI’s impact in preventing suicide.RecommendationsIt is recommended that Irish-based research is conducted to establish APSI’s impact in preventing suicide with a view to rolling out APSI as a national mental health clinical care programme.
Turnaround management strategies in local authorities: managerial, political and national obstacles to recovery
Authors: Beeri Itai , Navot Doron 
Published: June 2014

AbstractOver recent decades, nations worldwide have been struggling with public finance difficulties and other organizational and functional challenges that,inter alia, led to the EU Fiscal Stability Treaty in 2012. Under various reforms, poor-performing local authorities are subject to continuous pressure to employ turnaround management strategies – strategies borrowed from the private sector that are assumed to be effective in public-sector contexts. Based on insights from institutional theory, we argue not only that turnaround management strategies have been either poorly matched to the causes of failure in the government sector or poorly implemented, but that turnaround management strategies will almost always tend to fail in the public context. Based on survey data collected in local authorities, we empirically verify this argument. Theoretical and practical lessons for improving reforms in the government sector and other public organizations that face crisis are suggested.
Iron and zinc concentrations in peanut (Arachis hypogaeaL.) seeds and their relationship with other nutritional and yield parameters
Authors: JANILA PASUPULETI , NIGAM S. N. , ABHISHEK R. , ANIL KUMAR V. , MANOHAR S. S. , VENUPRASAD R. 
Published: June 2014

SUMMARYBiofortification (delivery of micronutrientsviamicronutrient-dense crops) can be achieved through plant breeding and offers a cost-effective and sustainable approach to fighting micronutrient malnutrition. The present study was conducted to facilitate the initiation of a breeding programme to improve the concentration of iron (Fe) and zinc (Zn) in peanut (Arachis hypogaeaL.) seeds. The experiment was conducted with 64 diverse peanut genotypes for 2 years in eight different environments at the International Crops Research Institute for the Semi-Arid Tropics, Patancheru, India to assess the genetic variation for Fe and Zn concentrations in peanut seeds and their heritability and correlations with other traits. Significant differences were observed among the genotypes and environments for Fe (33–68 mg/kg), Zn (44–95 mg/kg), protein (150–310 mg/g) and oil (410–610 mg/g) concentration in seeds and their heritability was high, thus indicating the possibility of improving them through breeding. As seen in other plants, a significant positive association between concentrations of Fe and Zn was observed. Trade-offs between pod yield and Fe and Zn concentrations were not observed and the same was also true for oil content. Besides being high yielding, genotypes ICGV 06099 (57 mg/kg Fe and 81 mg/kg Zn) and ICGV 06040 (56 mg/kg Fe and 80 mg/kg Zn) had stable performance for Fe and Zn concentrations across environments. These are the ideal choices for use as parents in a breeding programme and in developing mapping populations.
Liberals and conservatives can show similarities in negativity bias
Authors: Brandt Mark J. , Wetherell Geoffrey , Reyna Christine 
Published: June 2014

AbstractNegativity bias may underlie the development of political ideologies, but liberals and conservatives are likely to respond to threats similarly. We review evidence from research on intolerance, motivated reasoning, and basic psychological threats that suggest liberals and conservatives are more similar than different when confronting threatening groups, situations, and information.
Political infants? Developmental origins of the negativity bias
Authors: Kinzler Katherine D. , Vaish Amrisha 
Published: June 2014

AbstractThe negativity bias in human cognition emerges in infancy and continues throughout childhood. To fully understand the relationship between differences in attention to negative stimuli and variance in political ideologies, it is critical to consider human development and the process by which early individual differences in negativity unfold and are shaped by both genes and environment.
Threat bias, not negativity bias, underpins differences in political ideology
Authors: Lilienfeld Scott O. , Latzman Robert D. 
Published: June 2014

AbstractAlthough disparities in political ideology are rooted partly in dispositional differences, Hibbing et al.'s analysis paints with an overly broad brush. Research on the personality correlates of liberal–conservative differences points not to global differences in negativity bias, but to differences in threat bias, probably emanating from differences in fearfulness. This distinction bears implications for etiological research and persuasion efforts.
Differences in negativity bias probably underlie variation in attitudes toward change generally, not political ideology specifically
Authors: Ludeke Steven G. , DeYoung Colin G. 
Published: June 2014

AbstractMany of the characteristics cited in Hibbing et al.'s account are ineffective predictors of economic conservatism. However, these same characteristics are often associated with differences not only in social conservatism but also in religiousness and authoritarianism. Hibbing et al. may have offered a useful explanation of traditionalism and attitudes toward change across domains rather than of general political attitudes.
The role of negativity bias in political judgment: A cultural neuroscience perspective
Authors: Pornpattananangkul Narun , Cheon Bobby K. , Chiao Joan Y. 
Published: June 2014

AbstractHibbing et al. provide a comprehensive overview of how being susceptible to heightened sensitivity to threat may lead to conservative ideologies. Yet, an emerging literature in social and cultural neuroscience shows the importance of genetic and cultural factors on negativity biases. Promising avenues for future investigation may include examining the bidirectional relationship of conservatism across multiple levels of analysis.
Explaining ideology: Two factors are better than one
Authors: Robbins Philip , Shields Kenneth 
Published: June 2014

AbstractHibbing et al. contend that individual differences in political ideology can be substantially accounted for in terms of differences in a single psychological factor, namely, strength of negativity bias. We argue that, given the multidimensional structure of ideology, a better explanation of ideological variation will take into account both individual differences in negativity bias and differences in empathic concern.