bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract IA09: Dynamic regulation of MYC and MYCN ubiquitination
Authors: Aifantis Iannis 
Published: October 2015

Abstract
The Myc proto-oncogenes have a well-established role in cellular transformation as well as in the maintenance of stem cells. Although the majority of previous studies have focused on the transcriptional regulation of Myc, the observation that Myc proteins have exceptionally short half-lives and that small perturbations in their expression lead to vast physiological consequences has illuminated the considerable importance of their post-translational regulators. Accordingly, FBXW7, which encodes a crucial subunit of the E3 ligase complex that polyubiquitylates both c-myc and N-myc, is one of the most frequently mutated genes in human cancers, including T-cell acute lymphoblastic leukemia (T-ALL). To study the effects of such lesions, we generated animals carrying regulatable Fbxw7 mutant alleles. We haave demonstrated that these mutations specifically bolster tumor-initiating activity in collaboration with NOTCH1 oncogenes, but spare normal hematopoietic stem cell (HSC) function. Stabilization of c-myc defines leukemia-initiating cells (LIC) and we demonstrated that the LIC population can be specifically ablated in vivo by depletion of c-myc, genetically or pharmacologically. Finally, we uncover a novel role for the HECT-family E3 ligase Huwe1 in the maintenance of HSC self-renewal and show that it functions specifically by controlling the stability of N-myc, but not c-myc. Molecular targets and interplay between c-Myc and N-Myc will be also presented and discussed, with a focus on hematopoiesis and induction of leukemia.
Citation Format: Iannis Aifantis. Dynamic regulation of MYC and MYCN ubiquitination. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr IA09.
Abstract IA23: An ancient signaling mechanism mediates the response of cells to fitness differences arising during tissue growth
Authors: Johnston Laura A. 
Published: October 2015

Abstract
Much work indicates that cells in developing tissues and organs use conserved mechanisms that allow them to cooperate or compete with their neighbors. These mechanisms allow cells to sense and respond to growth changes in their immediate environment, help to promote appropriate size control and ensure optimal organ fitness. One such mechanism, called cell competition, monitors cellular fitness so that potentially unfit cells are prevented from contributing to the tissue. We have developed models to determine how cell competition is regulated. In one model, mosaic tissues that contain cells with increased activity of the Myc transcription factor “compete” with wild-type cells and instruct them to die. As a result the higher-Myc cells (“winners”) are stimulated to proliferate more to fill the space. In another, cells deficient in one copy of a ribosomal protein compete with wild-type cells for occupancy of the tissue. Our recent work reveals that both types of cell competition use specific cohorts of components of the evolutionarily ancient innate immune system to eliminate the weaker cells. We find that Toll-related receptors (TRRs) and the cytokine Spätzle lead to NFkB-dependent apoptosis in both “loser” cell populations. However, diverse “loser” cells require different TRRs and NFkB factors, and activate distinct pro-death genes. Our results imply that the particular response to cell fitness differences is stipulated by context, just as innate immune genes respond to a variety of microbial pathogens. Our findings demonstrate a functional repurposing of components of TRRs and NFkB signaling modules in an internal cell fitness surveillance system that operates during development.
Citation Format: Laura A. Johnston. An ancient signaling mechanism mediates the response of cells to fitness differences arising during tissue growth. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr IA23.
Abstract PR02: Dynamic epigenetic regulation of glioblastoma tumorigenicity through a LSD1-MYC-OLIG2 axis
Authors: Chen Clark , Kozono David , Li Jie , Nitta Masayuki , Sampetrean Oltea , Ng Kimberly , Gonda David , Kushwaha Deepa S. , Merzon Dmitry , Ramakrishnan Valya , Zhu Shan , Zhu Kaya , Matsui Hiroko , Harismendy Olivier , Hua Wei , Mao Ying , Kwon Chang-Hyuk , Ligon Keith L. , Saya Hideyuki , Carter Bob S. , Pizzo Donald P. , VandenBerg Scott R. , Furnari Frank , Cavenee Webster 
Published: October 2015

Abstract
Glioblastoma is one of the most devastating of human cancers, with near-uniform fatality within two years of diagnosis. Therapeutic failure is thought to be related to small subpopulation of cells that exhibit the properties of self-renewal and tumorigenicity. Understanding how such subpopulations attain and retain these properties remains a central question in oncology. One fundamental issue is whether tumorigenicity exists within a static population of elite cells or whether the capacity is stochastically acquired. To test these models, we assayed the tumorigenicity of single-cell subclones derived from long-terms passaged and primary patient-derived xenograft (PDX) glioblastoma lines. Our findings were best described by a hybrid model that is largely deterministic (elite) but with opportunities for dynamic (stochastic) interchange between non-tumorigenic and tumorigenic states. To identify molecular determinants of tumorigenicity, we performed gene expression profiling of the subclones. Analysis of the data suggested that tumorigenicity in glioblastoma is a dynamic property driven by variation in MYC expression, which in turn regulates Olig2 expression, a neural stem cell marker. Ectopic expression of MYC conferred tumorigenicty and MYC silencing abolished tumorigenicity in vitro and in vivo for multiple PDX and GEMM models. Transition between tumorigenic and non-tumorigenic cell states was associated with changes in histone modification at the MYC locus mediated by expression of lysine-specific demethylase 1 (LSD1). The model suggests a critical LSD1-MYC-OLIG2 axis that regulates the dynamic transition between glioblastoma cell states of differing tumorigenicity and unveils a novel framework for glioblastoma therapeutic development.
Citation Format: Clark Chen, David Kozono, Jie Li, Masayuki Nitta, Oltea Sampetrean, Kimberly Ng, David Gonda, Deepa S. Kushwaha, Dmitry Merzon, Valya Ramakrishnan, Shan Zhu, Kaya Zhu, Hiroko Matsui, Olivier Harismendy, Wei Hua, Ying Mao, Chang-Hyuk Kwon, Keith L. Ligon, Hideyuki Saya, Bob S. Carter, Donald P. Pizzo, Scott R. VandenBerg, Frank Furnari, Webster Cavenee. Dynamic epigenetic regulation of glioblastoma tumorigenicity through a LSD1-MYC-OLIG2 axis. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr PR02.
Early Dynamics of Deep Blue XBT Probes
Authors: Bringas Francis , Goni Gustavo 
Published: October 2015

AbstractExpendable bathythermographs (XBTs) are probes widely used to monitor global ocean heat content, variability of ocean currents, and meridional heat transports. In the XBT temperature profile, the depth is estimated from the time of descent in the water using a fall-rate equation. There are two main errors in these profiles: temperature and depth errors. The reduction of error in the estimates of the depth allows a corresponding reduction in the errors in the computations in which XBTs are used. Two experiments were carried out to study the effect of the deployment height on the depth estimates of Deep Blue XBT probes. During these experiments, XBTs were deployed from different heights. The motion of the probes after entering the water was analyzed to determine the position and the velocity of the probes as a function of time, which was compared to that obtained using the Hanawa et al. fall-rate equation. Results showed a difference or offset between the experimentally observed depths and those derived from Hanawa et al. This offset was found to be linked to the deployment height. To eliminate the offset in the fall-rate equation for XBTs deployed from different heights, a methodology is proposed here based on the initial velocities of the probes in the water (or deployment height). Results indicate that the depth estimates in the profiles need to be corrected for an offset, which in addition to having a launch height dependence is time dependent during the first 1.5 s of descent of the probe in the water, and constant after that.
Suppression of Tinnitus in Chinese Patients Receiving Regular Cochlear Implant Programming
Authors: Liu Ying , Wang Hong , Han Dong Xu , Li Ming Hua , Wang Yu , Xiao Yu Li 
Published: October 2015

Objective: To assess the clinical effect of cochlear implant programming on tinnitus. Methods: Tinnitus patients (n = 234) were divided into 3 groups: (1) preoperative tinnitus (n = 108), (2) postoperative tinnitus occurring before implant switch-on at week 4 (n = 88), and (3) tinnitus occurring more than 1 year postoperatively (n = 44). Patients in each group were randomly allocated into a programming subgroup that received programming for 12 weeks postoperatively or after tinnitus occurrence or a control subgroup. Impedance testing and the Tinnitus Handicap Inventory (THI) were performed preoperatively and at 4, 6, 8, and 12 weeks postoperatively (groups 1 and 2) or after tinnitus occurrence (group 3). Comparisons were performed using t tests and chi-square tests. Results: Impedance was significantly lower in the programming subgroup than in the control subgroup in groups 1 and 2 at 8 and 12 weeks and in group 3 at 12 weeks. The THI scores decreased in both programming and control subgroups in all groups. However, this decrease was pronounced in the programming subgroup, whereas in the control subgroup, it occurred slowly over time. Conclusion: Cochlear implant programming decreases impedance and improves tinnitus symptoms.
Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012
Authors: Khaja Sobia F. , Hoffman Henry T. , Pagedar Nitin A. 
Published: October 2015

Objective: To identify trends in treatment and survival for patients with stage I glottic cancer and glottic carcinoma in situ (CIS). Methods: The 18-registry SEER data were analyzed for CIS and stage I glottic cancer. Treatment variables and observed and relative survival were assessed separately for stage I and glottic CIS. Results: Among 14 025 cases of stage I glottic cancer identified from 1988 to 2012, radiation was the most common treatment for all eras. An increase in surgical treatment occurred with a decline in combination therapy. There were 3169 cases of glottic CIS, with surgery the most common initial treatment but with radiotherapy increasing across the years. Relative survival was similar for treatment type and era of diagnosis. Among the 3738 patients with glottic CIS, 5.4% went on to develop invasive glottic carcinoma of any stage, with invasive cancer more common in patients treated by surgery alone compared to radiation or surgery with radiation. Conclusions: Despite changes in treatment modalities for CIS and stage I glottic cancer, there have not been significant changes in survival for CIS, with slightly improved survival for treatment with surgery alone. Patients treated with surgery alone had an increased rate of subsequent invasive cancer.
The development and preliminary evaluation of an education intervention to prevent driveway run-over incidents
Authors: Armstrong Kerry A , Watling Hanna , Davey Jeremy 
Published: October 2015

Objective: While driveway run-over incidents continue to be a cause of serious injury and deaths among young children in Australia, few empirically evaluated educational interventions have been developed which address these incidents. Addressing this gap, this study describes the development and evaluation of a paper-based driveway safety intervention targeting caregivers of children aged 5 years or younger. Design: Cross-sectional survey. Method and setting: Informed by previous research, the intervention targeted key caregiver safety behaviours that address driveway risks. To assess the impact of the intervention, 137 Queensland (Australia) caregivers (95.0% women; mean age = 34.97 years) were recruited. After receiving the intervention, changes to a number of outcomes such as caregiver risk perception, safety knowledge and behavioural intentions were measured. Results: Findings indicated that the intervention had increased general and specific situational risk awareness and safety knowledge among a substantial proportion of participants. Close to one-quarter of the sample strongly agreed that the intervention had increased these outcomes. In addition, 71.6% of the sample reported that they intended to make changes to their routine in and around the driveway, as a result of reading the intervention material and a further, quarter of the participants strongly agreed that the information provided would be a help both to themselves (26.5%) and other caregivers (33.8%) to keep their children safe in the driveway. Conclusion: While the educational intervention requires further validation, findings from this study suggest that intervention content and format increases driveway safety.
Cutaneous asthenia (Ehlers–Danlos-like syndrome) of Burmese cats
Authors: Hansen Naomi , Foster Susan F , Burrows Amanda K , Mackie John , Malik Richard 
Published: October 2015

Summary of cases: A 6-month-old Burmese kitten developed focal skin lesions following a routine ovariohysterectomy. These were eventually attributed to the patient struggling during catheter placement and induction of anaesthesia. The lesions were caused by fluid extravasation in the subcutis and ischaemic necrosis of the overlying dermis, giving rise to an eschar-like appearance. Such lesions have been seen previously in Burmese cats with cutaneous asthenia and it is thought that they arise due to poor collagenous support for dermal blood vessels. An increased skin extensibility index (>23%) supported a diagnosis of cutaneous asthenia (Ehlers–Danlos-like syndrome), which has been reported as an inherited condition of Burmese cats in Australia, New Zealand and Europe. An additional Burmese cat with cutaneous asthenia is presented in detail, with lifetime follow-up and further salient observations by the owner, a veterinarian. Photographs of three other affected Burmese cats are provided to illustrate the range of presentations encountered with this condition. All five affected cats were presented with eschars, atrophic alopecia and increased skin extensibility, while one cat also had skin ulcers. Routine histopathological examination, including use of special stains such as trichrome, was unhelpful in establishing the diagnosis. Clinical review: The clinical features of this genetic disease of Burmese cats are reviewed, especially in relation to the postulated ‘vasculopathy’ that gives rise to characteristic skin lesions. Long term management of this condition is discussed briefly.
Development and evaluation of a controlled drug delivery wound dressing based on polymeric porous microspheres
Authors: Khurshid Muhammad Furqan , Hussain Tanveer , Masood Rashid , Hussain Nisar 
Published: October 2015

The aim of the present work was to develop and evaluate a controlled drug delivery wound dressing based on polymeric porous microspheres, which are also termed as microsponge drug delivery system. For this purpose, turmeric (drug)-based polymeric porous microspheres formulations were developed by quasi-emulsion solvent diffusion method. The production yields, actual drug content, drug entrapment efficiency, particle size, formulation of the material, and in vitro release were studied. On the basis of maximum drug released, a formulation was selected to incorporate into wound dressings with the help of a binder by spraying technique. Finally, the selected formulation and samples of wound dressings containing microsponges were subjected to scanning electron microscopy and drug release analyses. The result of in vitro release shows that microsponge drug delivery system is a versatile tool that has a potential to convert any wound dressing into a controlled drug delivery wound dressing.
A McShane-type identity for closed surfaces
Authors: Huang Yi 
Published: October 2015

Abstract.We prove a McShane-type identity: a series, expressed in terms of geodesic lengths, that sums to 2π for any closed hyperbolic surface with one distinguished point. To do so, we prove a generalized Birman-Series theorem showing that the set of complete geodesics on a hyperbolic surface with large cone angles is sparse.
Trauma Related Guilt Inventory – psychometric properties of the Polish adaptation (TRGI-PL)
Authors: Popiel Agnieszka , Zawadzki Bogdan 
Published: October 2015

CelPoczucie winy to częsty problem pacjentów z PTSD, lecz dopiero w obecnej wersji DSM-5 znalazło odzwierciedlenie w kryteriach diagnostycznych. Poznawcza konceptualizacja zaproponowana przez Kubanyego została odzwierciedlona w narzędziu do oceny związanego z traumą poczucia winy –TRGI. Celem artykułu jest prezentacja właściwości psychometrycznych polskiej adaptacji inwentarza – TRGI-PL.MetodaBadaniem TRGI-PL objęto 280 uczestników wypadków komunikacyjnych (147 kobiet, 133 mężczyzn w wieku od 18 to 80 lat (M=34,93; SD=13,71), w okresie od jednego do 24 miesięcy po wypadku (M=10,18, SD=6,23). Walidacja narzędzia TRGI-PL polegała na zbadaniu struktury czynnikowej oraz określeniu trafności teoretycznej pomiaru - porównaniu emocjonalnych i poznawczych składowych poczucia winy badanych przez TRGI-PL z nasileniem objawów PTSD (mierzonych PTSD-K), przekonaniami potraumatycznymi (PTCI), nasileniem emocji negatywnych, oraz oceną sprawstwa wypadku przez sąd i subiektywną akceptacją tej oceny przez osobę badaną.WynikiWskaźniki dopasowania modelu zakładającego czteroczynnikową strukturę poczucia winy (1) Dystres; (2) Możliwość Przewidzenia i Zapobieżenia Wydarzeniu/ Odpowiedzialność; (3) Brak Usprawiedliwienia dla Własnych Zachowań; (4) Potępienie Własnych Czynów) są zadowalające (Satorra-Bentler chi2=518,62; df=203, p<0,01, RMSEA=0,079, CFI=0,96, GFI=0,97) i odpowiadają uzyskiwanym w badaniach nad oryginalną wersją językową. Uzyskane wyniki wskazują też na porównywalną z wersją oryginalną rzetelność i trafność teoretyczną pomiaru TRGI-PL.WnioskiWłasności psychometryczne TRGI-PL są porównywalne z narzędziem oryginalnym w ocenie poczucia winy jako wielowymiarowego konstruktu obejmującego składowe emocjonalne i poznawcze. Polska adaptacja – TRGI-PL może być użytecznym narzędziem do badania poczucia winy występującego u osób po traumatycznych doświadczeniach, planowania interwencji terapeutycznych i monitorowania przebiegu terapii.
Analysis of psychiatric consultations in a multidisciplinary hospital patients
Authors: Ścisło Piotr , Badura-Brzoza Karina , Gorczyca Piotr , Błachut Michał , Pudlo Robert , Piegza Magdalena , Hese Robert 
Published: October 2015

CelCelem pracy jest analiza konsultacji psychiatrycznych przeprowadzanych w szpitalu wielospecjalistycznym, ustalenie przyczyn konsultacji na podstawie analizy rozpoznań wg. ICD-10 oraz analiza konsultacji psychiatrycznych pod względem liczby na poszczególnych oddziałachMetodaW badaniu przeprowadzono retrospektywną analizę dokumentacji medycznej dotyczącej udzielonych konsultacji w ramach szpitala wielospecjalistycznego w Tarnowskich Górach w latach 2002-2010.W badaniach statystycznych wykorzystano m.in. : test Shapiro-Wilka, test Kruskala-Wllisa, test U Manna-Whitney’a, test niezależności CHI2WynikiW badanych latach odbyły się 3672 konsultacje, średnia wieku pacjentów konsultowanych wynosiła 46.9 lat. Wśród osób konsultowanych 41.99% stanowiły kobiety, 58.01% mężczyźni. Rozpoznania główne w ujęciu odsetkowym wszystkich konsultacji przedstawiały się następująco: F00-F09: 18,82%, F10-F19: 29,58%, F20-F29: 17,70%, F30-F39: 10,29%, F40-F48: 13,83%, F50-F59: 0,16%, F60-F69: 3,21%, F70-F79: 1,77%, F80-F89:0%, F90-F98: 1,01%,inne: 3,62%. Konsultacje odbywały się najczęściej na następujących oddziałach : Izba Przyjęc-13,21%,Szpitalny Oddział Ratunkowy-6,97%,Chirurgia-8,42%,Interna-6,51%,Neurologia-4,82%.WnioskiNajczęstszą przyczyną konsultacji były uzależnienia, następnie zaburzenia organiczne oraz zaburzenia psychotyczne, zaburzenia nerwicowe i afektywne. Konsultacje odbywały się najczęściej na Izbie Przyjęć /Szpitalnym Oddziale Ratunkowym, Chirurgii oraz Oddziale Wewnętrznym i Neurologii
Stability and boundedness of solutions of a certain n-dimensional nonlinear delay differential system of third-order
Authors: Mahmoud Ayman M. , Tunç Cemil 
Published: October 2015

AbstractIn this paper, by defining Lyapunov functionals, we investigate proper sufficient conditions for the uniform stability of the zero solution, and also for the uniform boundedness and uniform ultimate boundedness of all solutions of a certain third-order nonlinear vector delay differential equation of the type
Quantification of β-region IgA monoclonal proteins – should we include immunochemical Hevylite® measurements? Point
Authors: Evans Josie A.R. , Jenner Ellen L. , Carr Smith Hugh D. , Berlanga Oscar , Harding Stephen J. 
Published: October 2015

AbstractAccurate measurement of IgA monoclonal proteins presents a significant challenge to laboratory staff. IgA heavy/light chain (Hevylite, HLC) analysis is an alternative methodology for monoclonal protein assessment, giving an independent measure of IgAκ and IgAλ concentrations. Clonality is assessed by calculating the ratio of involved immunoglobulin to background uninvolved immunoglobulin concentrations (e.g. IgAκ/IgAλ in an IgAκ patient). Here we discuss the challenges faced by the laboratory in IgA monoclonal protein assessment, and compare the performance of Hevylite assays with electrophoresis and total IgA results. We present data which validates the use of Hevylite for response assessment: in most cases, Hevylite provides comparable response assignment to that provided by serum protein electrophoresis (SPE) and total IgA; in other cases Hevylite provides additional information, such as detection of residual disease or relapse.
Predicting the gender of Welsh nouns
Authors: Hammond Michael 
Published: October 2015

AbstractWelsh grammatical gender exhibits several unusual properties. This paper argues that these properties are necessarily connected. The argument is based on a series of corpus investigations using techniques from statistical natural language processing, specifically distinguishing properties that exhibit significant statistical patterns from those which can be used to make useable predictions. Specifically, it’s shown that the grammatical properties of Welsh gender are such that its unusual statistical properties follow.
A case of hereditary novel mutation in SLC26A2 gene (c.1796 A.> C) identified in a couple with a fetus affected with atelosteogenesis type 2 phenotype in an antecedent pregnancy
Authors: Vikraman Seneesh Kumar , Balakrishnan Bijoy , Chandra Vipin , Batra Meenu , Kuriakose Rekha , Kannoly Gopinathan 
Published: October 2015

Abstract
Atelosteogenesis type 2 also known as atelosteogenesis de la Chapelle type, De la Chapelle dysplasia, McAlister dysplasia or neonatal osseous dysplasia 1 is an extremely lethal osteochondrodysplasia with unknown incidence. Very few cases have been reported in the literature. We present a case with findings of prenatal ultrasound, autopsy and cytogenetic work up with report of a novel familial mutation.