bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Targumic Interpretation in the Mishnah? Or a Case of Mistaken Identity?
Authors: Hayward Robert 
Published: February 2014

‭Interpretations of Exod. 17.11 and Num. 21.9 juxtaposed in Mishnah Rosh Ha-Shanah 3.8 bear strong resemblances to the Fragment Targum of these verses, while exhibiting certain marked differences. The Mekhilta also juxtaposes these verses using language close to that of mRH 3.6 without, however, employing terminology common to Targum and Mishnah. The same verses are explicated in tandem by the early Christian writers ‘Barnabas’ and Justin Martyr. The article explores pre-Christian interpretations of these verses and examines the wording of the Mishnah and the Targum, concluding that these texts can be regarded as extended ‘conversations’ between exegetes of different persuasions.‬
‘States not Governments’: Reforming Britain’s Practice on Diplomatic Recognition, 1973-1980
Authors: Young John W. 
Published: February 2014

Summary
The subject of recognition is basic to the way in which relations are conducted between states: they cannot easily communicate if they do not recognize one another’s existence. The question is also a difficult one in international law because, in practice, governments often adopt a pragmatic approach when specific instances of recognition arise. One important difference in practice was between countries — including Britain until 1980 — that extended recognition to particular governments and those that focused simply on the recognition of states. However, in April 1980, Britain’s Foreign Secretary, Lord Carrington, announced a change in practice, so that London would ‘recognize States in accordance with common international doctrine’. This announcement followed years of discussion within the Foreign and Commonwealth Office, a discussion that was influenced by complex legal considerations over recognition and by membership of the European Community. This article investigates how and why such a change in British practice on recognition came about, showing that the British also gave consideration to a compromise solution, which would have involved tacit recognition of new governments, short of dispensing with such recognition altogether.
Use of Flexible Esophagoscopy by Otolaryngologists
Authors: Wexler Sonya J. , Wernick Brian , Soliman Ahmed M. S. 
Published: February 2014

Objectives: We used questionnaires to determine current practice patterns for esophagoscopy by otolaryngologists in the United States, with attention to foreign body management. Methods: A 10-item questionnaire designed to determine the prevalence of flexible esophagoscopy use among otolaryngologists, with a particular focus on foreign body removal, was created and sent via e-mail to all members of the American Academy of Otolaryngology–Head and Neck Surgery. A second, 6-question survey to assess the level of resident training in flexible esophagoscopy was similarly created and sent to all directors of US otolaryngology residency programs. Results: There were a total of 160 respondents to the first survey from all geographic regions, most of whom were in group private practice. Overall, only 21.3% of the respondents were trained to perform flexible esophagoscopy during residency, whereas 43% of those who graduated after 1990 received this training. Most respondents performed flexible esophagoscopy without sedation in the office setting. The most common indications were evaluation of dysphagia, screening for complications of laryngopharyngeal reflux, and panendoscopy for head and neck cancer. Nearly 70% of the respondents were either primarily responsible for foreign body management at their institution or shared this responsibility with a gastroenterology department. Eighty-four percent used the rigid esophagoscope alone for this purpose. More than three quarters of otolaryngology residency programs currently include flexible esophagoscopy in their training, which is performed equally in the operating room and in the office; most favor rigid esophagoscopy for foreign body retrieval but use both techniques. Conclusions: There has been a rapid increase in the use of flexible esophagoscopy by otolaryngologists. The majority of residency programs currently include flexible esophagoscopy in their training. Otolaryngologists play a major role in esophageal foreign body management and primarily use the rigid esophagoscope for this purpose.
Bicarbonate Availability for Vocal Fold Epithelial Defense to Acidic Challenge
Authors: Durkes Abigail , Sivasankar M. Preeti 
Published: February 2014

Objectives: Bicarbonate is critical for acid-base tissue homeostasis. In this study we investigated the role of bicarbonate ion transport in vocal fold epithelial defense to acid challenges. Acidic insults to the larynx are common in gastric reflux, carcinogenesis and metastasis, and acute inflammation. Methods: Ion transport was measured in viable porcine vocal fold epithelium. First, 18 vocal folds were exposed to either the carbonic anhydrase antagonist acetazolamide or to vehicle. Second, 32 vocal folds were exposed to either a control buffer or a bicarbonate-free buffer on their luminal or basolateral surface or both. Third, 32 vocal folds were challenged with acid in the presence of bicarbonate-free or control buffer. Results: The vocal fold transepithelial resistance was greater than 300 Ω*cm2, suggesting robust barrier integrity. Ion transport did not change after exposure to acetazolamide (p > 0.05). Exposure to bicarbonate-free buffer did not compromise vocal fold ion transport (p > 0.05). Ion transport increased after acid challenge. This increase approached statistical significance and was the greatest for the control buffer and for the bicarbonate-free buffer applied to the basolateral surface. Conclusions: Bicarbonate secretion may contribute to vocal fold defense against acid challenge. Our data offer a potential novel role for bicarbonate as a therapeutic agent to reduce pH abnormalities in the larynx and prevent associated pathological changes.
Relapse Patterns After Transoral Laser Microsurgery and Postoperative Irradiation for Squamous Cell Carcinomas of the Tonsil and Tongue Base
Authors: Patel Samir H. , Munson Nathan D. , Grant David G. , Buskirk Steven J. , Hinni Michael L. , Perry William C. , Foote Robert L. , McNeil Rebecca B. , Halyard Michele Y. 
Published: February 2014

Objectives: We evaluated relapse patterns after transoral laser microsurgery (TLM) in squamous cell carcinoma (SCC) of the tonsil and tongue base and evaluated the indications for adjuvant irradiation. Methods: Between December 1, 1996, and December 31, 2005, 79 patients with previously untreated SCC of the tonsil or tongue base underwent TLM with or without neck dissection. Thirty-eight patients (48%) underwent postoperative irradiation (median, 62 Gy) to the primary site and the neck. Analysis of relapse patterns was performed on the basis of adverse risk factors and the presence or absence of adjuvant irradiation. Results: The median follow-up for living patients was 47 months (range, 10 to 107 months), and patients were monitored for at least 2 years or until recurrence or death. Local, regional, and distant treatment failures numbered 4, 6, and 4 for surgery alone (n = 41) and 0, 2, and 6 for adjuvant irradiation (n = 38), respectively. Patients with high-risk features (extracapsular extension or at least 2 adverse factors) had locoregional control rates at 2 or more years of 66% and 94% for TLM alone and TLM plus adjuvant irradiation, respectively. Conclusions: Adjuvant irradiation after TLM resection of oropharyngeal SCC with intermediate- or high-risk features improves locoregional control compared with TLM alone.
Comparison of Survival Rates Between Papillary and Follicular Thyroid Carcinomas Among 36,725 Patients
Authors: Oyer Sam L. , Fritsch Valerie A. , Lentsch Eric J. 
Published: February 2014

Objectives: We sought to determine the impact of histologic subtype on disease-specific survival (DSS) in cases of differentiated thyroid carcinoma. Methods: Adult patients with papillary thyroid carcinoma (PTC) or follicular thyroid carcinoma (FTC) were identified from the Surveillance, Epidemiology, and End Results (SEER) Database for the years 1988 to 2003. The patients were grouped according to tumor type (PTC or FTC), and their age, gender, tumor size and extension, and nodal or distant metastases were recorded. The Kaplan-Meier method was used to compare DSS rates on the basis of histologic subtype. Results: We identified 36,725 patients, of whom 77% were female and 23% were male; PTC was diagnosed in 91% of patients, and FTC in the remaining 9%. Patients with PTC were younger, were more likely to be female, and had smaller tumors with higher rates of regional metastases but fewer distant metastases than FTC patients (p < 0.0001 for all). When the cases were stratified by stage, FTC patients had a worse DSS than did PTC patients for all stages — except for stages III/IVA and IVC among patients more than 45 years of age. Conclusions: Follicular thyroid carcinoma portends a worse DSS than does PTC, even when the cases are controlled for stage. Consideration should be given to individual staging for these subtypes of differentiated thyroid carcinoma.
Stem Cell–Derived Tissue–Engineered Constructs for Hemilaryngeal Reconstruction
Authors: Halum Stacey L. , Bijangi-Vishehsaraei Khadijeh , Zhang Hongji , Sowinski John , Bottino Marco C. 
Published: February 2014

Objectives: As an initial step toward our goal of developing a completely tissue-engineered larynx, the aim of this study was to describe and compare three strategies of creating tissue-engineered muscle-polymer constructs for hemilaryngeal reconstruction. Methods: Cartilage-mimicking polymer was developed from electrospun poly(D,L-lactide-co-ε-caprolactone) (PCL). Primary muscle progenitor cell cultures were derived from syngeneic F344 rat skeletal muscle biopsies. Twenty F344 rats underwent resection of the outer hemilaryngeal cartilage with the underlying laryngeal adductor muscle. The defects were repaired with muscle stem cell–derived muscle–PCL constructs (5 animals), myotube-derived muscle–PCL constructs (5 animals), motor end plate–expressing muscle–PCL constructs (5 animals), or PCL alone (controls; 5 animals). The outcome measures at 1 month included animal survival, muscle thickness, and innervation status as determined by electromyography and immunohistochemistry. Results: All of the animals survived the 1-month implant period and had appropriate weight gain. The group that received motor end plate–expressing muscle–PCL constructs demonstrated the greatest muscle thickness and the strongest innervation, according to electromyographic activity and the percentage of motor end plates that had nerve contact. Conclusions: Although all of the tissue-engineered constructs provided effective reconstruction, those that expressed motor end plates before implantation yielded muscle that was more strongly innervated and viable. This finding suggests that this novel approach may be useful in the development of a tissue-engineered laryngeal replacement.
Ovine Model for Auricular Reconstruction
Authors: Hohman Marc H. , Lindsay Robin W. , Pomerantseva Irina , Bichara David A. , Zhao Xing , Johnson Matthew , Kulig Katherine M. , Sundback Cathryn A. , Randolph Mark A. , Vacanti Joseph P. , Cheney Mack L. , Hadlock Theresa A. 
Published: February 2014

Objectives: We developed a large animal model for auricular reconstruction with engineered cartilage frameworks and evaluated the performance of porous polyethylene auricular implants in this model. Methods: Eighteen high-density porous polyethylene auricular frameworks were implanted subcutaneously in the infra-auricular areas of 9 sheep. The implants were harvested 17 weeks later for gross and histologic examination. The perioperative and postoperative courses were carefully documented. Results: Five implants became exposed, and 2 implants needed to be removed at 7 weeks. Additionally, 1 infected implant was removed at 2 weeks. Seromas developed in 2 implants because of drain failures and were drained successfully during the first postoperative week. There were no other surgical site complications. The remaining 10 implants had an acceptable cosmetic appearance at 17 weeks. Conclusions: The perioperative complication rate in the ovine porous polyethylene auricular implant model was higher than that reported for auricular reconstructions in humans. The implant exposures were likely caused by ischemia and excessive stress on the thin overlying skin, because vascularized flap coverage was not used. The histologic findings were comparable to the results reported for other animal models. This large animal model is appropriate for auricular reconstruction experiments, including engineered constructs.
Service users’ views of the assessment process in stroke rehabilitation
Authors: Tyson Sarah F , Burton Louisa-Jane , McGovern Alison , Sharifi Sudi 
Published: February 2014

Objective: To investigate the service users’ (stroke survivors and care-givers) experiences and views of the rehabilitation assessment process. Design: Qualitative data analysis from three focus groups using a content analysis to identify the major themes. Setting: Participants were recruited from stroke support groups and community rehabilitation services in a large UK city. Subjects: Seventeen community-dwelling stroke survivors who had completed their rehabilitation within the previous year and six care-givers. Results: Five themes emerged: understanding the purpose of the assessment; repetition of assessments; feedback about assessments and progress; format of feedback and barriers to feedback. While all participants reported undergoing assessment, some felt their purpose was not always explained and resented unexplained repetitions of tests. Some participants reported a positive experience, but most wanted more information about their progress and predictions of recovery. They wanted regular, consistent, objective information presented in layman’s terms; verbally and in writing. Some carers reported difficulty accessing information particularly as a result of confidentiality policies. While some participants accepted these short-comings, others considered them due to staff’s disinterest or ineptitude, which undermined their trust in the team. Conclusions: Stroke service users require clear information about the purpose of assessments and regular, consistent, objective feedback about their progress using layman’s language both verbally and in writing.
New endoscopic classification system for biliary stricture after liver transplantation
Authors: Qin Zhichu , Linghu En-Qiang 
Published: February 2014

Aim A new classification system for biliary stricture (BS) after liver transplantation (LT) is proposed, aiming to standardize endoscopic treatment for this condition. Methods Data were retrospectively collected from patients who had undergone endoscopic retrograde cholangiography after LT, and who provided endoscopy images clear enough to reveal the biliary system. Images were classified separately by two endoscopists, who discussed and resolved any disputed findings. From these images, a new classification system is proposed (Ling classification): type A, normal biliary structure; type B, anastomotic stricture and normal intrahepatic biliary structure; type C, narrow and stiff intrahepatic biliary structure or beaded intrahepatic biliary structure or intrahepatic biliary cast without anastomotic stricture; type D, narrow and stiff intrahepatic biliary structure or beaded intrahepatic biliary structure or intrahepatic biliary cast with anastomotic stricture. Results Analysis involved 93 patients: 76 men and 17 women, median age 54 years (range, 12–69 years). Type B was the most commonly observed BS after LT, accounting for 44 cases (47.3%). Type A, the least commonly observed type, accounted for nine (9.7%), type C for 22 (23.7%) and type D for 18 (19.3%) cases. Conclusion A new endoscopic classification system for BS after LT is proposed, to help determine the most appropriate treatment for patients with each type of stricture.
Injectable Collagen Implant Improves Survival, Cardiac Remodeling, and Function in the Early Period After Myocarditis in Rats
Authors: Rinkevich-Shop Shunit , Landa-Rouben Natalie , Epstein Frederick H. , Holbova Radka , Feinberg Micha S. , Goitein Orly , Kushnir Tammar , Konen Eli , Leor Jonathan 
Published: February 2014

Aim: Despite clear evidence of immune system involvement in the pathogenesis of myocarditis, the treatment of myocarditis remains nonspecific and supportive. We sought to test the hypothesis that injection of a collagen-based implant into the inflamed myocardium would stabilize the left ventricular (LV) wall and prevent adverse remodeling and dysfunction. Methods and Results: Autoimmune myocarditis was induced in 42 male Lewis rats. Development of myocarditis was evaluated and confirmed by serial echocardiography and cardiac magnetic resonance scans, LV wall thickening, global and regional LV wall motion abnormalities, and in some cases pericardial effusion. Sick animals were randomized to either injectable collagen implantation or saline injection into the anterior inflamed myocardium 14 days after immunization. Significantly, injectable collagen implantation improved 31-day survival compared with controls (85.7% vs 50%; P = .03). Furthermore, although injectable collagen significantly attenuated LV systolic and diastolic dilatation and preserved LV geometry and function, control animals developed significant LV dilatation and dysfunction. These favorable effects on LV remodeling were confirmed by postmortem morphometry. Significantly, the injectable collagen implant attenuated cardiomyocyte hypertrophy and infiltration of macrophages and lymphocytes into the myocardium. Conclusions: The present study shows, for the first time, that injectable collagen biomaterial improves survival and attenuates cardiac inflammation, cardiomyocyte hypertrophy, LV remodeling, and dysfunction in the early period after myocarditis in rats. Our findings suggest a new biomaterial-based strategy to ameliorate the devastating effects of myocarditis.
An Unusual Case of Chronic Lateral Foot Pain Following Ankle Inversion Injury
Authors: Aydogan Umur , Dellenbaugh Samuel G. 
Published: February 2014

Osteoid osteomas are common benign tumors normally seen in the femur, tibia, and spine. They rarely are seen in the foot. We present an unusual case of osteoid osteoma of the cuboid in a 26-year-old man. This was initially thought to be an ankle sprain, as its first presentation was after a sporting injury. It was then treated as an infection before the true diagnosis—that of osteoid osteoma—was obtained. Level of Evidence: Therapeutic, Level IV: Case study
Glenohumeral Function of the Long Head of the Biceps Muscle
Authors: Chalmers Peter N. , Cip Johannes , Trombley Robert , Cole Brian J. , Wimmer Markus A. , Romeo Anthony A. , Verma Nikhil N. 
Published: February 2014

Background: Optimal treatment of superior labral anterior-posterior (SLAP) tears is controversial, in part because the dynamic role of the long head of the biceps muscle (LHBM) in the glenohumeral joint is unclear. The aim of this study was to determine dynamic LHBM behavior during shoulder activity by studying (1) the electromyographic activity of the LHBM during shoulder motion, (2) the effect of elbow immobilization on this activity, and (3) the effect of a load applied to the distal humerus on this activity. Hypothesis: The LHBM would not play a significant role in active glenohumeral range of motion. Study Design: Controlled laboratory study. Methods: Thirteen normal volunteers underwent surface electromyography (EMG) measurement of the LHBM, short head biceps muscle (SHBM), deltoid, infraspinatus, and brachioradialis during shoulder motion from the neutral position (0° of rotation, flexion, and abduction) to 45° of flexion, 90° of flexion, 45° of abduction, and 90° of abduction. These motions were repeated both with and without splint immobilization of the forearm and elbow at 100° of flexion and neutral rotation and with and without a 1-kg weight placed on the lateral distal humerus. Results: Mean EMG activity within the LHBM and the SHBM was low (≤11.6% ± 9.1%). LHBM activity was significant increased by flexion and abduction ( P < .049 in all cases), while SHBM activity was not. EMG activity from the middle head of the deltoid was significantly increased by loading with the shoulder positioned away from the body (ie, in abduction or flexion). When compared with the unloaded state, the addition of a distal humeral load significantly increased LHBM activity in 45° of abduction ( P = .028) and 90° of flexion ( P = .033) despite forearm and elbow immobilization. The SHBM showed similar trends. Conclusion: In normal volunteers with forearm and elbow immobilization and application of a load to the distal humerus, LHBM EMG activity is increased by both glenohumeral flexion and abduction, suggesting that this muscle plays a dynamic role in glenohumeral motion with higher demand activities. Clinical Relevance: Biceps tenodesis may result in dynamic change within the glenohumeral joint with higher demand activities.
Assessment of the normal and pathological alignment of the elbow in children using the trochleocapitellar index
Authors: Gorelick Lauren , Robinson Dror , Loberant Norman , Rozano-Gorelick Ayala , Yassin Mustafa , Garti Avraham , Ram Edward 
Published: February 2014

Abstract

Background
The current research is a retrospective study that involves the description of a new trochleocapitellar index (TCI), on basis of anteroposterior (AP) radiographs of normal and fractured paediatric elbows. This index may be useful in assessing the alignment of the elbow with a supracondylar fracture.

Methods
The index was evaluated to define its normal and pathological range in children between the ages of 1–13 years. A total of 212 elbows in 141 children were radiographically evaluated. 70 children without fracture elbows were evaluated by radiographs taken at the time of trauma. 35 children with unilateral fractures that healed in a normal alignment were compared to 33 patients that had a mal-union and three patients with bilateral elbow fractures. The patients were radiographically assessed at the time of fracture as well as after fracture healing as part of a routine clinical assessment. Treatment included observation, cast or internal fixation as needed.

Results
The current study establishes that the normal range of the TCI was 0.25-0.8. The average TCI is 0.45. The lower range correlates with a valgus alignment of the elbow while the higher range indicates a neutral alignment. The TCI in fractured elbows that have healed in a clinically normal alignment is different than the contra-lateral elbow’s TCI. This might indicate a sub-clinical remaining deformity.

Conclusions
In current practice, paediatric patients with elbow trauma, often undergo bilateral radiographs during emergency room visits. The TCI has high negative and positive predictive values and might be superior to direct angle measurement that is currently in use. The use of the TCI measurement is expected to reduce exposure to irradiation in elbow trauma patients as bilateral comparative films appear to be superfluous when this measurement is used.