bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrolyte‐Assisted Structure Reconstruction Optimization of Sn‐Zn Hybrid Oxide Boosts the Electrochemical CO2‐to‐HCOO− Conversion
Authors: Feng Jinxian , Liu Chunfa , Qiao Lulu , An Keyu , Lin Sen , Ip Weng Fai , Pan Hui 
Published: August 2024

AbstractElectrolyte plays crucial roles in electrochemical CO2 reduction reaction (e‐CO2RR), yet how it affects the e‐CO2RR performance still being unclarified. In this work, it is reported that Sn‐Zn hybrid oxide enables excellent CO2‐to‐HCOO− conversion in KHCO3 with a HCOO− Faraday efficiency ≈89%, a yield rate ≈0.58 mmol cm−2 h−1 and a stability up to ≈60 h at −0.93 V, which are higher than those in NaHCO3 and K2SO4. Systematical characterizations unveil that the surface reconstruction on Sn‐Zn greatly depends on the electrolyte using: the Sn‐SnO2/ZnO, the ZnO encapsulated Sn‐SnO2/ZnO and the Sn‐SnO2/Zn‐ZnO are reconstructed on the surface by KHCO3, NaHCO3 and K2SO4, respectively. The improved CO2‐to‐HCOO− performance in KHCO3 is highly attributed to the reconstructed Sn‐SnO2/ZnO, which can enhance the charge transportation, promote the CO2 adsorption and optimize the adsorption configuration, accumulate the protons by enhancing water adsorption/cleavage and limit the hydrogen evolution. The findings may provide insightful understanding on the relationship between electrolyte and surface reconstruction in e‐CO2RR and guide the design of novel electrocatalyst for effective CO2 reduction.
Ubiquitination of NS1 Confers Differential Adaptation of Zika Virus in Mammalian Hosts and Mosquito Vectors
Authors: Huang Chenxiao , Jiang Tao , Pan Wen , Feng Tingting , Zhou Xia , Wu Qihan , Ma Feng , Dai Jianfeng 
Published: August 2024

AbstractArboviruses, transmitted by medical arthropods, pose a serious health threat worldwide. During viral infection, Post Translational Modifications (PTMs) are present on both host and viral proteins, regulating multiple processes of the viral lifecycle. In this study, a mammalian E3 ubiquitin ligase WWP2 (WW domain containing E3 ubiquitin ligase 2) is identified, which interacts with the NS1 protein of Zika virus (ZIKV) and mediates K63 and K48 ubiquitination of Lys 265 and Lys 284, respectively. WWP2‐mediated NS1 ubiquitination leads to NS1 degradation via the ubiquitin‐proteasome pathway, thereby inhibiting ZIKV infection in mammalian hosts. Simultaneously, it is found Su(dx), a protein highly homologous to host WWP2 in mosquitoes, is capable of ubiquitinating NS1 in mosquito cells. Unexpectedly, ubiquitination of NS1 in mosquitoes does not lead to NS1 degradation; instead, it promotes viral infection in mosquitoes. Correspondingly, the NS1 K265R mutant virus is less infectious to mosquitoes than the wild‐type (WT) virus. The above results suggest that the ubiquitination of the NS1 protein confers different adaptations of ZIKV to hosts and vectors, and more importantly, this explains why NS1 K265‐type strains have become predominantly endemic in nature. This study highlights the potential application in antiviral drug and vaccine development by targeting viral proteins' PTMs.
Are Sulfide‐Based Solid‐State Electrolytes the Best Pair for Si Anodes in Li‐Ion Batteries?
Authors: Sun Qing , Zeng Guifang , Xu Xiao , Li Jing , Biendicho Jordi Jacas , Wang Shang , Tian Yanhong , Ci Lijie , Cabot Andreu 
Published: August 2024

AbstractThe integration of Si‐based anodes within sulfide‐based solid electrolyte (SSE) Li‐ion batteries (LIB) has emerged as a promising avenue of research and development, attracting increasing interest in recent years. This work comprehensively examines the latest research directions and major strides in this field. It covers the key advances in the design and engineering of nano‐ and micro‐structured Si anode architectures, and strategies of surface modification. Additionally, it explores the impacts of external pressure, the role of binders and conductive additives, and the implications of varying Si particle size. Beyond providing a detailed account of the evolution of Si anodes within SSE LIBs, this work also identifies critical research challenges that urgently need addressing. These include the electrochemical‐mechanical evolution behavior and failure mechanism of Si anodes in SSE LIBs, strategies for structural and interface modifications, methods for preparing Si electrodes, advancements in high‐performance SSEs, and the development of scalable technologies for SSE thin films. Moreover, it discusses high‐energy cathodes tailored for Si‐based SSE LIBs. The identified research priorities are set to offer crucial guidance and insights, supporting the ongoing investigations and innovations in this dynamic area of research.
Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex
Authors: Lu Ziang , Xu Jinglei , Chen Yuqi , Zhou Yuanyuan , Zhou Xiaolu , Wang Qi , Wei Qi , Han Shaoqing , Zhao Ruiqi , Weng Xiaocheng , Zhang Xiaolian , Zhou Xiang 
Published: August 2024

AbstractAccumulating evidence indicates that G‐quadruplexes (G4s) are involved in transcriptional regulation. Previous studies have demonstrated that DHX36 preferentially resolves G4s, suggesting its potential impact on gene transcription mediated by these structures. However, systematic validation is required to establish a link between DHX36 activity and its roles in transcriptional regulation. In this study, we investigate the role of DHX36 in transcription. First, we employ the cleavage under targets and tagmentation (CUT&Tag), an efficient method for mapping protein–DNA interactions, to identify the binding sites in the chromatin of MCF‐7 cells. Subsequently, we use the auxin‐inducible degron (AID) protein degradation system and improved nascent RNA sequencing method acrylonitrile‐mediated uridine‐to‐cytidine conversion sequencing (AMUC‐seq) to pinpoint genes directly regulated by DHX36. Our results reveal a significant enrichment of G4 structures at DHX36 target sites, predominantly located in active genomic regions. In vitro assays further demonstrate DHX36's interaction with G4 sequences from three specific oncogenes. These findings underscore the potential role of DHX36 in modulating gene transcription through G4 structures.
Polaritonic Chemistry Enabled by Non‐Local Metasurfaces
Authors: Verdelli Francesco , Wei Yu‐Chen , Joseph Kripa , Abdelkhalik Mohamed S. , Goudarzi Masoumeh , Askes Sven H. C. , Baldi Andrea , Meijer E. W. , Gomez Rivas Jaime 
Published: August 2024

AbstractVibrational strong coupling can modify chemical reaction pathways in unconventional ways. Thus far, Fabry‐Perot cavities formed by pairs of facing mirrors have been mostly utilized to achieve vibrational strong coupling. In this study, we demonstrate the application of non‐local metasurfaces that can sustain surface lattice resonances, enabling chemical reactions under vibrational strong coupling. We show that the solvolysis kinetics of para‐nitrophenyl acetate can be accelerated by a factor of 2.7 by strong coupling to the carbonyl bond of the solvent and the solute with a surface lattice resonance. Our work introduces a new platform to investigate polaritonic chemical reactions. In contrast to Fabry‐Perot cavities, metasurfaces define open optical cavities with single surfaces, which removes alignment hurdles, facilitating polaritonic chemistry across large areas.
Highly Durable Inverted Inorganic Perovskite/Organic Tandem Solar Cells Enabled by Multifunctional Additives
Authors: Li Yanxun , Yan Yichao , Fu Yuang , Jiang Wenlin , Liu Ming , Chen Mingqian , Huang Xiaofeng , Lu Guanghao , Lu Xinhui , Yin Jun , Wu Shengfan , Jen Alex K.‐Y. 
Published: August 2024

AbstractInverted perovskite/organic tandem solar cells (P/O TSCs) suffer from poor long‐term device stability due to halide segregation in organic–inorganic hybrid wide‐band gap (WBG) perovskites, which hinders their practical deployment. Therefore, developing all‐inorganic WBG perovskites for incorporation into P/O TSCs is a promising strategy because of their superior stability under continuous illumination. However, these inorganic WBG perovskites also face some critical issues, including rapid crystallization, phase instability, and large energy loss, etc. To tackle these issues, two multifunctional additives based on 9,10‐anthraquinone‐2‐sulfonic acid (AQS) are developed to regulate the perovskite crystallization by mediating the intermediate phases and suppress the halide segregation through the redox‐shuttle effect. By coupling with organic cations having the desirable functional groups and dipole moments, these additives can effectively passivate the defects and adjust the alignment of interface energy levels. Consequently, a record Voc approaching 1.3 V with high power conversion efficiency (PCE) of 18.59 % could be achieved in a 1.78 eV band gap single‐junction inverted all‐inorganic PSC. More importantly, the P/O TSC derived from this cell demonstrates a T90 lifetime of 1000 h under continuous operation, presenting the most stable P/O TSCs reported so far.
Self‐Assembled Hydrazide‐Based Nanochannels: Efficient Water Translocation and Salt Rejection
Authors: Mondal Abhishek , Mondal Debashis , Sarkar Susmita , Shivpuje Umesh , Mondal Jagannath , Talukdar Pinaki 
Published: August 2024

AbstractNature has ingeniously developed specialized water transporters that effectively reject ions, including protons, while transporting water across membranes. These natural water channels, known as aquaporins (AQPs), have inspired the creation of Artificial Water Channels (AWCs). However, replicating superfast water transport with synthetic molecular structures that exclude salts and protons is a challenging task. This endeavor demands the coexistence of a suitable water‐binding site and a selective filter for precise water transportation. Here, we present small‐molecule hydrazides 1 b–1 d that self‐assemble into a rosette‐type nanochannel assembly through intermolecular hydrogen bonding and π‐π stacking interactions, and selectively transport water molecules across lipid bilayer membranes. The experimental analysis demonstrates notable permeability rates for the 1 c derivative, enabling approximately 3.18×108 water molecules to traverse the channel per second. This permeability rate is about one order of magnitude lower than that of AQPs. Of particular significance, the 1 c ensures exclusive passage of water molecules while effectively blocking salts and protons. MD simulation studies confirmed the stability and water transport properties of the water channel assembly inside the bilayer membranes at ambient conditions.
Allostery at a Protein‐Protein Interface Harboring an Intermolecular Motional Network
Authors: Medina Gomez Sara , Gonzalez Tye I. , Vasa Suresh K. , Linser Rasmus 
Published: August 2024

AbstractMotional properties of proteins govern recognition, catalysis, and regulation. The dynamics of tightly interacting residues can form intramolecular dynamic networks, dependencies fine‐tuned by evolution to optimize a plethora of functional aspects. The constructive interaction of residues from different proteins to assemble intermolecular dynamic networks is a similarly likely case but has escaped thorough experimental assessment due to interfering association/dissociation dynamics. Here, we use fast‐MAS solid‐state 15N R1ρ NMR relaxation dispersion aided by molecular‐dynamics simulations to mechanistically assess the hierarchy of individual μs timescale motions arising from a crystal‐crystal contact, in the absence of translational motion. In contrast to the monomer, where particular mutations entail isolated perturbations, specific intermolecular interactions couple the motional properties between distant residues in the same protein. The mechanistic insights obtained from this conceptual work may improve our understanding on how intramolecular allostery can be tuned by intermolecular interactions via assembly of dynamic networks from previously isolated elements.
Studies on Structure, Morphology and Antimicrobial and Anticancer Activities of [BMIM][BF4]‐Coated ZnO Nanoparticles
Authors: Rajarajeswari Arumugam , Stella Selvaraj 
Published: August 2024

ABSTRACTZinc oxide (ZnO) nanoparticles (NPs) coated with 1‐butyl‐3‐methylimidazolium tetrafluoroborate ionic liquid (IL) (ZnO‐[BMIM][BF4] NPs) and ZnO NPs without IL coating were both synthesized by co‐precipitation. Various analytical methods were used to characterize the synthesized NPs. X‐ray diffraction (XRD) analysis revealed that ZnO NPs had a mean crystallite size of 32 nm and that of ZnO‐[BMIM][BF4] NPs was 22 nm. IL alters the Fourier transform infrared spectroscopy (FTIR) peaks of the as‐prepared ZnO NPs. A blueshift was seen in the absorption peak of ZnO‐[BMIM][BF4] NPs as compared to bare ZnO NPs. An examination of the UV–visible (UV–Vis) spectra revealed that the optical bandgap decreases with the addition of IL to ZnO NPs. Scanning electron microscopy (SEM) and high‐resolution transmission electron microscopy (HR‐TEM) investigation revealed the morphology and size of the nanostructured particles. The chemically prepared ZnO‐[BMIM][BF4] NPs displayed the irregular spherical‐shaped morphologies in the range of nanoscale. Transmission electron microscopy (TEM) showed the conventional hexagonal wurtzite structure of ZnO‐[BMIM][BF4] NPs. Synthesized ZnO‐NPs in water have a zeta potential of −13.1 mV, showing that they are stable solutions. Thermal behaviour of ZnO NPs was studied using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The agar‐well diffusion technique was used to investigate and compare the antimicrobial activity of synthesized ZnO‐[BMIM][BF4] NPs against the following bacteria and fungi: Streptococcus aureus, Pseudomonas aeruginosa and Candida albicans. The MCF7 breast cancer cells were used to assess the anticancer capabilities of ZnO‐[BMIM][BF4] NPs at various doses (100 μg/mL, 10 μg/mL, 1 μg/mL, 100 ng/mL, 10 ng/mL and 1 ng/mL) using MTT assays. The range of cell inhibition was determined to be from 19.14% to 70.52%. The percentage of cytotoxicity increases was observed when the concentration of synthesized ZnO‐[BMIM][BF4] NPs ranges from 1 ng/mL to 100 μg/mL.
Molecular insights into the oleic acid accumulation in safflower
Authors: Salunke Gayatri , Badhe Yogesh , Singh Vrijendra , Ghorpade Prakash , Hegde Mahabaleshwar , Kadoo Narendra 
Published: August 2024

AbstractMost of the Indian safflower (Carthamus tinctorius L.) varieties produce oil rich in linoleic acid (LA, ~75%) and low in oleic acid (OA, ~15%). In the fatty acid biosynthetic pathway, the fatty acid desaturase 2 (FAD2) enzyme converts OA to LA. Safflower is reported to have 12–20 FAD2 genes. Gene expression analysis of four FAD2 genes during seed development in a high LA variety, PBNS‐12, revealed high expression of FAD2‐1 at 21 days after flowering (DAF), correlating with high LA accumulation. Fatty acid profiling of 448 Indian safflower germplasm accessions revealed four lines to have high (58%–77%) OA content, with NASF‐39 having the highest OA content. Interestingly, all four high OA lines showed the same mutation in the FAD2‐1 gene. The DNA sequence of FAD2‐1 from the four high OA lines showed a deletion of C at the +606 position, resulting in a premature stop codon at the +733 position and a truncated protein of 244 amino acids. Hence, despite the high expression levels of FAD2‐1 in NASF‐39 at 18–21 DAF, it exhibited high OA (77%). The dysfunctional nature of the truncated FAD2‐1 in NASF‐39 was evident in molecular docking studies with 1‐stearoyl‐2‐oleoyl phosphatidylcholine. We also sequenced FATB, a thioesterase responsible for releasing stearic acid from acyl carrier protein for further desaturation to oleic acid, where an A773G substitution was observed. This resulted in E258G substitution in NASF‐39 FATB compared to that of PBNS‐12. This probably made the acyl‐binding pocket of NASF‐39 FATB unstable, contributing to high OA accumulation. Thus, the outcomes of this study can help develop super and ultra‐high oleic safflower varieties through various genetics and genomics approaches.
Suppression of Zinc Dendrite Growth by Enhanced Polyacrylamide Gel Electrolytes in Zinc‐Ion Battery
Authors: Yuan Jingjing , Li Yifan , Ma Yuqing , Ruan Yuan , He Junjie , Xu Hui , Zhang Zhongqiang , He Guangyu , Chen Haiqun 
Published: August 2024

AbstractAqueous zinc‐ion batteries have become a promising energy storage battery due to high theoretical specific capacity, abundant zinc resources and low cost. However, zinc dendrite growth and hydrogen evolution reaction limit their application. This study aims to improve the cycling performance and stability of aqueous zinc‐ion batteries by improving the gel electrolyte. Polyacrylamide (PAM) is selected as the base material of the gel electrolyte, which has good stability and safety, but the water retention capacity, Zn2+ migration number, and ionic conductivity of PAM are low, which affects the long‐term stability of the battery. In response to these problems, we optimized PAM by chemical cross‐linking method, and formed an enhanced PAM gel by adding disodium citrate dihydrate (SC). Experimental results show that the introduction of an appropriate amount of SC in the enhanced PAM gel electrolyte can significantly improve its electrochemical performance. The zinc‐ion symmetric battery achieved a stable cycle of more than 2100 hours at a current density of 0.5 mA cm−2, which is mainly attributed to the inhibitory effect of the enhanced PAM gel on zinc dendrite growth and hydrogen evolution reaction. This study provides a new direction for the development and application of flexible zinc‐ion batteries.
A Clean Slate: Adapting the Realization Effect to Online Gambling and Its Effectiveness in People With Gambling Problems
Authors: Zhang Ke , Imas Alex , Clark Luke 
Published: August 2024

ABSTRACTBetting more after losses (i.e., “loss‐chasing”) is a central clinical feature of disordered gambling. According to prospect theory, increasing risk‐seeking following losses could arise from a failure to “re‐reference.” By contrast, successful re‐referencing between successive decisions closes the mental account, and any losses are regarded as final or realized; gamblers should not chase realized losses. The present study sought to test this “realization effect” among gamblers using an ecologically valid online gambling task. We were further interested in whether the effectiveness of the loss realization varied as a function of problem gambling severity. Using online recruitment of past‐year gamblers stratified on the Problem Gambling Severity Index, we tested a group without gambling problems (n = 227), a group with at‐risk gambling (n = 239), and a group with gambling problems (n = 223). Over a sequence of nine bets, after the sixth bet, half of the participants underwent a simulated realization procedure that entailed cashing out from the gambling website and redepositing their remaining funds on another website. The feedback comparison group were shown their account balance after the sixth bet but did not withdraw or transfer their funds. In line with the realization effect, the group with non‐problem gambling significantly reduced their bet after cashing out. The realization procedure did not significantly ameliorate loss‐chasing in the groups with at‐risk gambling or gambling problems. We conclude that the realization effect can be elicited in an online gambling context but that stronger interventions for realizing losses may be required for people experiencing gambling problems.
The interplay of cash flow uncertainty and firm life cycle on sustainability disclosure
Authors: Shiljas K , Kumar Dilip 
Published: August 2024

AbstractThis study investigates the role of cash flow uncertainty and firm life cycle on sustainability disclosures using environmental, social and governance (ESG) disclosure score data. We conduct our analysis on a sample of 190 Indian firms for a period of 12 years from 2010 to 2021. Drawing upon the real‐option theory and organisational‐inertia theory, we document a negative impact of cash flow uncertainty and firm life cycle on a firm's commitment to disclose sustainability information. We also find a significant impact of managerial risk inclination and risk tolerance at the firm level in moderating the above relationships. Our findings can help managers equip themselves to meet the challenges of sustainability commitments during cash flow constraints and firm life‐cycle transitions. Moreover, our results can also help policymakers in assessing the need to enforce sustainability disclosures depending on the hurdles confronted by a firm.
Acyclovir‐induced psychiatric and renal adverse effects in a diabetic patient: A case report
Authors: Roshanzamiri Soheil , Mousavizadeh Seyyedeh Azam , Razazzadeh Sareh , Ziaie Shadi 
Published: August 2024

Key Clinical MessageAcyclovir can cause neurotoxicity and nephrotoxicity, especially in diabetic patients with renal impairment. Consider acyclovir dose adjustment, close monitoring of kidney function, and hemodialysis as a potential therapeutic option in such cases.
Cardiac interventricular septum hemangioma in a colon cancer patient treated with Capecitabine: A case report and review of literature
Authors: Zonooz Yasamin Afsari , Alizadehasl Azin , Davani Delaram Narimani , Jebelli Seyedeh Fatemeh Hosseini , Aliabadi Azam Yalameh , Najdaghi Soroush , Meshgi Shahla , Shafieeardestani Soudabeh 
Published: August 2024

Key Clinical MessageWe report a case of a 21‐year‐old male with stage IIIB sigmoid colon adenocarcinoma who experienced atypical chest pain post‐adjuvant chemotherapy with Capecitabine (5‐FU prodrug). Evaluation revealed an unexpectedly detected interventricular septum hemangioma. Due to the vasospasm effect of chemotherapy presenting with semi‐ischemia, conservative management was chosen for atypical presentation.
Concomitant manifestations of systemic lupus erythematosus flare‐up and nodal marginal zone B‐cell lymphoma in a 41‐year‐old male patient: A challenging case report
Authors: Zarafshani Mohammadkian , Rahmanian Ehsan , Manouchehri Ardekani Reza , Matini Seyed Amir Hassan , Loghman Maryam , Faezi Seyedeh Tahereh 
Published: August 2024

Key Clinical MessageMalignancy may be a possible cause of systemic lupus erythematosus (SLE) flare‐ups, and it is necessary to consider it in the context of treatment resistance. In this case, we present a challenging instance of concomitant nodal marginal zone B‐cell lymphoma (NMZL) and SLE flare‐up in a 41‐year‐old male patient.AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that can cause various symptoms and affect multiple organs in the body. It is also associated with the development of malignancies, especially lymphomas. This case report discusses a patient who experienced a flare‐up of SLE along with hypercalcemia, which led to the diagnosis of nodal marginal zone B‐cell lymphoma (NMZL). This is the first case of its kind to be reported. A 41‐year‐old man with a 10‐year history of SLE and antiphospholipid syndrome (APS) was referred to our center due to several symptoms, including fatigue, oral lesions, dyspnea, bilateral wrist pain and inflammation, mild pericardial effusion, organ enlargement, pancytopenia, high erythrocyte sedimentation (ESR) level, high anti‐double stranded DNA (anti‐dsDNA) level, low complement level, resistant hypercalcemia, and high brain natriuretic peptide (pro‐BNP) level. After further testing, it was discovered that the patient had NMZL, which was the ultimate diagnosis. He underwent six cycles of the R‐CHOP chemotherapy regimen, and his clinical and laboratory conditions improved during follow‐ups. The initial case of SLE flare‐up, with concomitant NMZL is being reported as the final diagnosis. In simpler terms, it is possible for lymphoma to manifest as a potential cause of SLE flare‐ups, and clinicians should be mindful that they need to consider malignant conditions when faced with treatment resistance.