bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Aligned and Laminated Nanostructured Carbon Hybrid Cathode for High‐Performance Lithium–Sulfur Batteries
Authors: Sun Qian , Fang Xin , Weng Wei , Deng Jue , Chen Peining , Ren Jing , Guan Guozhen , Wang Min , Peng Huisheng 
Published: July 2015

AbstractAn aligned and laminated sulfur‐absorbed mesoporous carbon/carbon nanotube (CNT) hybrid cathode has been developed for lithium–sulfur batteries with high performance. The mesoporous carbon acts as sulfur host and suppresses the diffusion of polysulfide, while the CNT network anchors the sulfur‐absorbed mesoporous carbon particles, providing pathways for rapid electron transport, alleviating polysulfide migration and enabling a high flexibility. The resulting lithium–sulfur battery delivers a high capacity of 1226 mAh g−1 and achieves a capacity retention of 75 % after 100 cycles at 0.1 C. Moreover, a high capacity of nearly 900 mAh g−1 is obtained for 20 mg cm−2, which is the highest sulfur load to the best of our knowledge. More importantly, the aligned and laminated hybrid cathode endows the battery with high flexibility and its electrochemical performances are well maintained under bending and after being folded for 500 times.
Selective Alcohol Oxidation by a Copper TEMPO Catalyst: Mechanistic Insights by Simultaneously Coupled Operando EPR/UV‐Vis/ATR‐IR Spectroscopy
Authors: Rabeah Jabor , Bentrup Ursula , Stößer Reinhard , Brückner Angelika 
Published: July 2015

AbstractThe first coupled operando EPR/UV‐Vis/ATR‐IR spectroscopy setup for mechanistic studies of gas‐liquid phase reactions is presented and exemplarily applied to the well‐known copper/TEMPO‐catalyzed (TEMPO=(2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl) oxidation of benzyl alcohol. In contrast to previous proposals, no direct redox reaction between TEMPO and CuI/CuII has been detected. Instead, the role of TEMPO is postulated to be the stabilization of a (bpy)(NMI)CuII‐O2⋅−‐TEMPO (bpy=2,2′‐bipyridine, NMI=N‐methylimidazole) intermediate formed by electron transfer from CuI to molecular O2.
Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti‐Cancer Properties
Authors: Krastel Philipp , Roggo Silvio , Schirle Markus , Ross Nathan T. , Perruccio Francesca , Aspesi Peter , Aust Thomas , Buntin Kathrin , Estoppey David , Liechty Brigitta , Mapa Felipa , Memmert Klaus , Miller Howard , Pan Xuewen , Riedl Ralph , Thibaut Christian , Thomas Jason , Wagner Trixie , Weber Eric , Xie Xiaobing , Schmitt Esther K. , Hoepfner Dominic 
Published: July 2015

AbstractCultivation of myxobacteria of the Nannocystis genus led to the isolation and structure elucidation of a class of novel cyclic lactone inhibitors of elongation factor 1. Whole genome sequence analysis and annotation enabled identification of the putative biosynthetic cluster and synthesis process. In biological assays the compounds displayed anti‐fungal and cytotoxic activity. Combined genetic and proteomic approaches identified the eukaryotic translation elongation factor 1α (EF‐1α) as the primary target for this compound class. Nannocystin A (1) displayed differential activity across various cancer cell lines and EEF1A1 expression levels appear to be the main differentiating factor. Biochemical and genetic evidence support an overlapping binding site of 1 with the anti‐cancer compound didemnin B on EF‐1α. This myxobacterial chemotype thus offers an interesting starting point for further investigations of the potential of therapeutics targeting elongation factor 1.
In vitro hydrolysis and magnesium release of poly(d,l‐lactide‐co‐glycolide)‐based composites containing bioresorbable glasses and magnesium hydroxide
Authors: Uppstu Peter , Paakki Charlotta , Rosling Ari 
Published: July 2015

ABSTRACTMagnesium is important for both bone growth and cartilage formation. However, the postoperative intake of antibiotics such as quinolones may cause a reduction in magnesium levels in tissue. The addition of magnesium to scaffolds may therefore be beneficial for the regeneration of osteochondral defects. In this study, porous composite scaffolds were produced by gas foaming of poly(d,l‐lactide‐co‐glycolide) (PLGA) rods with magnesium‐containing bioresorbable glasses and magnesium hydroxide as fillers. The in vitro hydrolytical degradation of the composite scaffolds in Tris buffer was followed over a 10‐week period. Mg2+ was released in a controlled manner from the scaffolds with varying release profiles between the different materials. Higher glass content resulted in a reduced mass loss compared to scaffolds with lower glass content. As a result of the foaming method, the scaffolds shrank initially, without evidence that the addition of hydrophilic fillers would decrease the initial shrinkage. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42646.
The Investigation of the Ardales Cave, Spain – 3D Documentation, Topographic Analyses, and Lighting Simulations based on Terrestrial Laser Scanning
Authors: Hoffmeister Dirk , Zellmann Stefan , Pastoors Andreas , Kehl Martin , Cantalejo Pedro , Ramos José , Weniger Gerd‐Christian , Bareth Georg 
Published: July 2015

AbstractThis contribution shows the application of terrestrial laser scanning in an integrative approach for the documentation and analyses of the Ardales Cave, southern Spain, which is in many respects an important geoarchaeological site. For the survey of the cave, a combination of the Riegl LMS Z420i laser scanner with a real‐time kinematic global positioning system (RTK‐GPS) from Topcon and further tachymetric measurements were used. The achieved three‐dimensional (3D) model of the cave and the surrounding hill documents the current topography and dimensions of the cave. Additional geoarchaeological data were successfully integrated in a 3D geographical information system (GIS) database and high‐resolution records of a structured‐light scanner were combined with the 3D model of the cave. The 3D model is further used for the estimation of the ceiling thickness that reveals areas for additional entrances. Lighting simulations based on path tracing were conducted for the determination of areas that are reached by natural direct or indirect light. In this case, the weight and size of the instrument was a logistic constraint to reach certain areas and to achieve a complete model of the cave. Overall, the method is feasible for the documentation of this cave and the investigations based on the derived 3D models. Copyright © 2015 John Wiley & Sons, Ltd.
IMAC capture of recombinant protein from unclarified mammalian cell feed streams
Authors: Kinna Alexander , Tolner Berend , Rota Enrique Miranda , Titchener‐Hooker Nigel , Nesbeth Darren , Chester Kerry 
Published: July 2015

ABSTRACTFusion‐tag affinity chromatography is a key technique in recombinant protein purification. Current methods for protein recovery from mammalian cells are hampered by the need for feed stream clarification. We have developed a method for direct capture using immobilized metal affinity chromatography (IMAC) of hexahistidine (His6) tagged proteins from unclarified mammalian cell feed streams. The process employs radial flow chromatography with 300–500 μm diameter agarose resin beads that allow free passage of cells but capture His‐tagged proteins from the feed stream; circumventing expensive and cumbersome centrifugation and/or filtration steps. The method is exemplified by Chinese Hamster Ovary (CHO) cell expression and subsequent recovery of recombinant His‐tagged carcinoembryonic antigen (CEA); a heavily glycosylated and clinically relevant protein. Despite operating at a high NaCl concentration necessary for IMAC binding, cells remained over 96% viable after passage through the column with host cell proteases and DNA detected at ∼8 U/mL and 2 ng/μL in column flow‐through, respectively. Recovery of His‐tagged CEA from unclarified feed yielded 71% product recovery. This work provides a basis for direct primary capture of fully glycosylated recombinant proteins from unclarified mammalian cell feed streams. Biotechnol. Bioeng. 2016;113: 130–140. © 2015 Wiley Periodicals, Inc.
Pharmacokinetic study of ofloxacin enantiomers in Pagrosomus major by chiral HPLC
Authors: Nie Jing , Wang Yang–Guang , Gao Xiao–Feng , OuYang Xiao–kun , Yang Li–Ye , Yu Di , Wu Wei–jian , Xu Hong–Ping 
Published: July 2015

Abstract(S)‐(−)‐Ofloxacin and (R)‐(+)‐ofloxacin concentrations in the plasma of Pagrosomus major after drug treatment were detected by chiral high‐performance liquid chromatography, and various pharmacokinetic parameters were calculated from these data. The elimination half‐life of (S)‐(−)‐ofloxacin was significantly shorter than that of the (R)‐(+) enantiomer. (S)‐(−)‐Ofloxacin also had a significantly lower maximum plasma concentration, area under the concentration–time curve from zero to infinity, and mean residence time than (R)‐(+)‐ofloxacin. However, the apparent volume of distribution and total body clearance of (S)‐(−)‐ofloxacin were greater than those of (R)‐(+)‐ofloxacin. The ratio of the (S)‐(−)‐ to (R)‐(+)‐ofloxacin plasma concentration was always <1.0. Together, these data suggest that (S)‐(−)‐ofloxacin was preferentially excreted and (R)‐(+)‐ofloxacin was preferentially absorbed. Although the difference in pharmacokinetic parameters was small, the metabolic behavior of the ofloxacin enantiomers in P. major was enantioselective. Copyright © 2015 John Wiley & Sons, Ltd.
Origin of the right coronary artery from the opposite sinus of Valsalva in adults: Characterization by intravascular ultrasonography at baseline and after stent angioplasty
Authors: Angelini Paolo , Uribe Carlo , Monge Jorge , Tobis Jonathan M. , Elayda MacArthur A. , Willerson James T. 
Published: July 2015

ObjectivesWe attempted to characterize the anatomy, function, clinical consequences, and treatment of right‐sided anomalous coronary artery origin from the opposite side (R‐ACAOS).BackgroundAnomalous aortic origin of a coronary artery is a source of great uncertainty in cardiology. A recent study by our group found that ACAOS had a high prevalence (0.48%) in a general population of adolescents.MethodsSixty‐seven consecutive patients were diagnosed with R‐ACAOS according to a new definition: ectopic right coronary artery (RCA) with an intramural proximal course. We used intravascular ultrasonograms of the RCA to quantify congenital stenosis (in patients with potentially serious clinical presentations), and we correlated these measurements with clinical manifestations.ResultsAll patients had some proximal intramural stenosis (mean 50%, range 16–83% of the cross‐sectional area). Forty‐two patients (62%) underwent stent‐percutaneous coronary intervention (PCI) of R‐ACAOS because of significant symptoms, positive stress tests, and/or significant stenosis. Stent‐PCI was successful in all cases and correlated with improved symptoms at >1‐year follow‐up in 30 patients (71%) who were available for clinical follow‐up. No ACAOS‐related deaths occurred. The instent restenosis rate was 4/30 (13%) at a mean follow‐up time of 5.0 years.ConclusionsThis preliminary, but large and unprecedented observational study shows that cases angiographically identified as R‐ACAOS universally feature an intramural aortic course but only occasionally severe stenosis on resting IVUS imaging. Our data suggest that stent‐PCI with IVUS monitoring ameliorates patients’ presenting symptoms. © 2015 Wiley Periodicals, Inc.
Plerixafor as a salvage mobilization strategy for haploidentical peripheral blood allogeneic stem cell transplantation
Authors: Nadeau Michelle , George Laeth , Yeager Andrew M. , Anwer Faiz , McBride Ali 
Published: July 2015

Key Clinical MessageIn allogeneic stem cell mobilization, peripheral blood stem cell mobilization with filgrastim can be considered standard of care. Poor mobilizers may be at risk for inadequate stem cell collection during apheresis. He we present a successful case of salvage plerixafor use with filgrastim in a haploidentical identical transplant patient.
ReDrop – A Simulation Tool for the Design of Extraction Columns Based on Single‐Drop Experiments
Authors: Ayesterán José , Kopriwa Nicole , Buchbender Florian , Kalem Murat , Pfennig Andreas 
Published: July 2015

AbstractThe design of extraction columns based on information from lab experiments and appropriate simulation tools allows reduction of time and costs compared to conventional design methods using pilot‐plant experiments. For this purpose, the behavior of drops and drop swarms is investigated in lab‐scale experiments in order to create mathematical models containing system‐specific parameters that have to be fitted to those experiments. These models are implemented in a simulation program that solves drop‐population balances in extraction columns. At AVT‐Thermal Process Engineering of the RWTH Aachen University this concept was implemented in the program ReDrop. ReDrop can predict the separation performance and flooding point of pulsed sieve tray and structured as well as random‐packing extraction columns for standard and technical systems. The program has successfully been extended to columns with rotating internals.
Chemical Modification of Graphene Oxide through Diazonium Chemistry and Its Influence on the Structure–Property Relationships of Graphene Oxide–Iron Oxide Nanocomposites
Authors: Rebuttini Valentina , Fazio Enza , Santangelo Saveria , Neri Fortunato , Caputo Gianvito , Martin Cédric , Brousse Thierry , Favier Frédéric , Pinna Nicola 
Published: July 2015

Abstract4‐Carboxyphenyl groups are covalently grafted onto graphene oxide via diazonium chemistry for studying their role on the adsorption of iron oxide nanoparticles. The nanoparticles are deposited via a novel phase‐transfer approach involving specific interactions at the interface between two immiscible solvents. The increased density and the homogeneous distribution of surface carboxyl moieties enable the preparation of a nanocomposite with improved iron oxide distribution and loading. Structure‐properties relationships are investigated by analysing the electrochemical properties of the nanocomposites, which are regarded as promising active materials for application in supercapacitors. It is demonstrated that the nature of the interactions between the components similarly affects the overall electrochemical performances of the nanocomposites and the structure of the materials.
Advancing Nanochemistry Education
Authors: Pagliaro Mario 
Published: July 2015

AbstractThe chemical approach to nanotechnology that has emerged in the last three decades has proved to be extremely fertile. As chemistry increasingly turns into nanochemistry, and renewable solar energy available in sunlight and in biomass emerges as the main energy and raw materials source available to mankind, effective teaching of nanochemistry becomes increasingly important. This Viewpoint identifies the requirements of a short course aimed to provide future scholars with the conceptual foundations, and a clear perspective, of an important discipline which turned out to be the enabler of nanotechnology.
Stereoselective Synthesis of Highly Functionalized Hydroindoles as Building Blocks for Rostratins B–D and Synthesis of the Pentacyclic Core of Rostratin C
Authors: Zhong Sabilla , Sauter Paul F. , Nieger Martin , Bräse Stefan 
Published: July 2015

AbstractThe stereoselective synthesis of a variety of functionalized hydroindoles suitable as building blocks for thiodiketopiperazine natural products such as rostratins B–D is reported. The key precursor for all transformations is a previously reported hexahydroindole compound. All functional groups were installed with the desired stereochemistry and the feasibility of the synthetic strategy was exemplified by dimerization of two hydroindole units to form the pentacyclic C2‐symmetric scaffold of rostratin C.
Monitoring Glycan–Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH–π Interactions
Authors: Calle Luis P. , Echeverria Begoña , Franconetti Antonio , Serna Sonia , Fernández‐Alonso M. Carmen , Diercks Tammo , Cañada F. Javier , Ardá Ana , Reichardt Niels‐Christian , Jiménez‐Barbero Jesús 
Published: July 2015

AbstractDetection of molecular recognition processes requires robust, specific, and easily implementable sensing methods, especially for screening applications. Here, we propose the difluoroacetamide moiety (an acetamide bioisoster) as a novel tag for detecting by NMR analysis those glycan–protein interactions that involve N‐acetylated sugars. Although difluoroacetamide has been used previously as a substituent in medicinal chemistry, here we employ it as a specific sensor to monitor interactions between GlcNAc‐containing glycans and a model lectin (wheat germ agglutinin). In contrast to the widely employed trifluoroacetamide group, the difluoroacetamide tag contains geminal 1H and 19F atoms that allow both 1H and 19F NMR methods for easy and robust detection of molecular recognition processes involving GlcNAc‐ (or GalNAc‐) moieties over a range of binding affinities. The CHF2CONH‐ moiety behaves in a manner that is very similar to that of the natural acetamide fragment in the involved aromatic‐sugar interactions, providing analogous binding energy and conformations, whereas the perfluorinated CF3CONH‐ analogue differs more significantly.
Synthesis of BiOClxBr1−x Nanoplate Solid Solutions as a Robust Photocatalyst with Tunable Band Structure
Authors: Zhang Xing , Wang Li‐Wei , Wang Chu‐Ya , Wang Wei‐Kang , Chen Ya‐Li , Huang Yu‐Xi , Li Wen‐Wei , Feng Yu‐Jie , Yu Han‐Qing 
Published: July 2015

AbstractThe use of bismuth oxyhalides as photocatalysts has received extensive interest because of their high photocatalytic activity and stability. However, available methods for the synthesis of bismuth oxyhalides with tailored morphologies, well‐defined facets, and tunable band gaps are still lacking. In this work, two‐dimensional BiOClxBr1−x solid solution with exposed {001} facets and tunable band gaps were synthesized by using solvothermal methods. The BiOClxBr1−x solid solution nanoplates crystallized in a homogeneous crystal structure but possessed continuously tuned band gaps from 3.39 to 2.78 eV by decreasing the ratio of Cl/Br. Among the synthesized nanoplates, the BiOCl0.5Br0.5 sample exhibited the highest photocatalytic activity for degrading Rhodamine B (RhB), a typical organic pollutant, under visible light. The highest photoactivity of the BiOCl0.5Br0.5 sample was attributed to a synergetic effect of higher surface area, facets exposed, and optimized band structure. The results are of profound significance for the design of novel photocatalyst materials.
Color Tuning of the Aggregation‐Induced Emission of Maleimide Dyes by Molecular Design and Morphology Control
Authors: Imoto Hiroaki , Kizaki Kohei , Watase Seiji , Matsukawa Kimihiro , Naka Kensuke 
Published: July 2015

AbstractAggregation‐induced emission (AIE)‐active maleimide dyes, namely, 2‐p‐toluidino‐N‐p‐tolylmaleimide, 3‐phenyl‐2‐toluidino‐N‐p‐tolylmaleimide, 2‐p‐thiocresyl‐3‐p‐toluidino‐N‐p‐tolylmaleimide, and 2,3‐dithiocresyl‐N‐arylmaleimides, were synthesized by facile synthetic procedures. The dyes show intense emission in the solid state, and emission colors were controlled from green (λmax=527 nm) to orange (λmax=609 nm) by varying the substituents at the 2‐ and 3‐positions of the maleimide and the packing structures in the solid state. 2,3‐Disubstituted maleimide dyes effectively underwent redshifts of their emission wavelength. Furthermore, some of the dyes exhibited mechanochromism and polymorphism, and their emission properties were dramatically dependent on the morphology of the solid samples. The mechanisms of the emission behaviors were investigated by X‐ray diffraction. The substituent of the nitrogen atom of the maleimide ring affected the intermolecular interactions and short contacts, which were observed by single crystal X‐ray crystallography, to result in completely different emission properties.
Regiospecific Intermolecular Aminohydroxylation of Olefins by Photoredox Catalysis
Authors: Miyazawa Kazuki , Koike Takashi , Akita Munetaka 
Published: July 2015

AbstractA simple and regiospecific aminohydroxylation of olefins by photoredox catalysis has been developed. N‐protected 1‐aminopyridinium salts are the key compounds and serve as amidyl radical precursors by the action of Ir photocatalysts, fac‐[Ir(ppy)3] and [Ir(ppy)2(dtbbpy)](PF6) (ppy=2‐pyridylphenyl, dtbbpy=4,4′‐di‐tert‐butyl‐2,2′‐bipyridine). The present photocatalytic system allows for synthesis of vicinal aminoalcohol derivatives from olefins with various functional groups under mild reaction conditions with easy handling.
Enantio‐ and Diastereoselective Formal Hetero‐Diels–Alder Reactions of Trifluoromethylated Enones Catalyzed by Chiral Primary Amines
Authors: Lin Yong‐Jun , Du Li‐Na , Kang Tai‐Ran , Liu Quan‐Zhong , Chen Ze‐Qin , He Long 
Published: July 2015

AbstractEnantioselective formal hetero‐Diels‐Alder reactions of trifluoromethylated enones and 2‐amino‐1,3‐butadienes generated in situ from aliphatic acyclic enones and chiral primary amines are reported. The corresponding tetrahydropyran‐4‐ones are formed in up to 94 % yield and with up to 94 % ee. The reaction was carried out through a stepwise mechanism, including initial aminocatalytic aldol condensation of 2‐amino‐1,3‐butadiene to the trifluoromethylated carbonyl group followed by an intramolecular oxa‐Michael addition. Both NMR investigation and theoretical calculations on the transition state indicate that the protonated tertiary amine could effectively activate the carbonyl group of the trifluoromethyl ketone to promote the addition process through hydrogen‐bonding interaction of NH⋅⋅⋅F and NH⋅⋅⋅O simultaneously, and thus provide a chiral environment for the approach of amino‐1,3‐butadienes to the activated trifluoromethyl ketone, resulting in high enantioselectivity.
Self‐Assembly of Tyrosine into Controlled Supramolecular Nanostructures
Authors: Ménard‐Moyon Cécilia , Venkatesh V. , Krishna K. Vijaya , Bonachera Fanny , Verma Sandeep , Bianco Alberto 
Published: July 2015

AbstractIn the context of designing novel amino acid nanostructures, the capacity of tyrosine alone to form well‐ordered structures under different conditions was explored. It was observed that Tyr can self‐assemble into well‐defined morphologies when deposited onto surfaces for transmission electron microscopy, atomic force microscopy, and scanning electron microscopy. The influence of various parameters that can modulate the self‐assembly process, including concentration of the amino acid, aging time, and solvent, was studied. Different supramolecular architectures, including nanoribbons, branched structures, and fern‐like arrangements were also observed.
A Stable Dimer of SiS2 Arranged between Two Carbene Molecules
Authors: Mohapatra Chandrajeet , Mondal Kartik Chandra , Samuel Prinson P. , Keil Helena , Niepötter Benedikt , Herbst‐Irmer Regine , Stalke Dietmar , Dutta Sayan , Koley Debasis , Roesky Herbert W. 
Published: July 2015

AbstractThe Me‐cAAC:‐stabilized dimer of silicon disulfide (SiS2) has been isolated in the molecular form as (Me‐cAAC:)2Si2S4 (2) at room temperature [Me‐cAAC:=cyclic alkyl(amino) carbene]. Compound 2 has been synthesized from the reaction of (Me‐cAAC:)2Si2 with elemental sulfur in a 1:4 molar ratio under oxidative addition. This is the smallest molecular unit of silicon disulfide characterized by X‐ray crystallography, electron ionization mass spectrometry, and NMR spectroscopy. Structures with three sulfur atoms arranged around a silicon atom are known; however, 2 is the first structurally characterized silicon–sulfur compound containing one terminal and two bridging sulfur atoms at each silicon atom. Compound 2 shows no decomposition after storing for three months in an inert atmosphere at ambient temperature. The bonding of 2 has been further studied by theoretical calculations.