bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palmitate de palipéridone à doses flexibles chez des patients non-aigus atteints de schizophrénie après échec d’un autre traitement par antipsychotiques injectables à action prolongée
Authors: Cherubin P. , Hargater L. , Bergmans B. , Bjorner A. , Knegtering H. , Parellada E. , Carpiniello B. , Vidailhet P. , Mertens C. , Schreiner A. 
Published: November 2013

ObjectifsÉvaluer la tolérance, la sécurité d’emploi et la réponse à un traitement par palmitate de palipéridone (PP) à doses flexibles chez des patients non aigus atteints de schizophrénie, après échec d’un traitement par un autre antipsychotique injectable à action prolongée : décanoate d’halopéridol (Déc-Hal), décanoate de flupentixol (Déc-Fpt), décanoate de fluphénazine (Déc-Flu), zuclopenthixol (Zuc) ou rispéridone à libération prolongée (RIS-LP).MéthodesÉtude internationale, prospective, ouverte, de six mois, chez des patients atteints de schizophrénie, non aigus mais insuffisamment contrôlés par d’autres antipsychotiques injectables à action prolongée.Critères d’évaluationTaux de réponse (amélioration ≥ 20 % du score total à la PANSS [Positive and Negative Syndrome Scale]), score à la PSP (Personal and Social Performance scale), événements indésirables (EIs).RésultatsLes analyses ont été réalisées sur la population en intention de traiter de façon stratifiée pour chaque traitement : 53 patients Déc-Hal, 35 Déc-Fpt, 44 Déc-Flu, 42 Zuc, 56 RIS-LP. Les scores totaux moyens à la PANSS initiale variaient de 67,7 ± 20,3 [RIS-LP] à 75,7 ± 13,2 [Déc-Hal]. Entre 71,4 % [RIS-LP] et 85,7 % [Déc-Fpt] des patients ont terminé l’étude. À la fin de l’étude, 53,7 % [Zuc], 54,7 % [Déc-Hal], 59,1 % [Déc-Flu], 61,1 % [RIS-LP] et 61,8 % [Déc- Fpt] des patients ont vu leur score total à la PANSS diminuer d’au moins 20 %. Les scores moyens de PSP de base étaient de 48,7 [Déc-Hal], 59,6 [Déc-Fpt], 53,5 [Déc-Flu], 52,9 [Zuc] et 60,1 [RIS-LP], et le changement en fin d’étude était respectivement de : 5,2 ; 6,1 ; 6,0 ; 6,4 ; et 5,2 (p ≤ 0,0163 pour tous les traitements). Les EIs rapportés au moins une fois dans tous les sous-groupes : douleur au site d’injection, insomnie, trouble psychotique.ConclusionsLe PP à doses flexibles a été bien toléré et a permis une réponse thérapeutique cliniquement significative chez des patients non aigus atteints de schizophrénie, après échec d’un traitement par d’autres antipsychotiques injectables à action prolongée.
Metaphors and creativity: Direct, moderating, and mediating effects
Authors: Marin Alex , Reimann Martin , Castaño Raquel 
Published: November 2013

AbstractThrough five experiments, this research advances knowledge about the influence of metaphors on creative cognition by showing that perceiving images that carry metaphoric meaning can alter consumers' creativity. While the results of Experiment 1 reveal that positive metaphors representing ideas like “Thinking outside the box” increase creative output, Experiment 2 uncovers that a negative metaphor conveying “I am burnt out” decreases it. Experiment 3 shows that the metaphor–creativity link is moderated by analogical reasoning skills, and Experiments 4a and 4b reveal the mediating role of creative intent. In addition to implying that marketers can use metaphors to enhance consumers' creative feedback in areas like new product development, this research also makes important theoretical contributions by showing (1) that metaphors that are visually conveyed (in addition to tangible objects or physical exercises) can not only raise but also lower creative output, (2) that a unique cognitive skill alters the metaphor–creativity link, and (3) that consumers' creative intent contributes to that relationship.
Seeing the world through GREEN‐tinted glasses: Green consumption values and responses to environmentally friendly products
Authors: Haws Kelly L. , Winterich Karen Page , Naylor Rebecca Walker 
Published: November 2013

AbstractThe primary goal of this research is to conceptualize and develop a scale of green consumption values, which we define as the tendency to express the value of environmental protection through one's purchases and consumption behaviors. Across six studies, we demonstrate that the six‐item measure we develop (i.e., the GREEN scale) can be used to capture green consumption values in a reliable, valid, and parsimonious manner. We further theorize and empirically demonstrate that green consumption values are part of a larger nomological network associated with conservation of not just environmental resources but also personal financial and physical resources. Finally, we demonstrate that the GREEN scale predicts consumer preference for environmentally friendly products. In doing so, we demonstrate that stronger green consumption values increase preference for environmentally friendly products through more favorable evaluations of the non‐environmental attributes of these products. These results have important implications for consumer responses to the growing number of environmentally friendly products.
THEORY FROM CHAOS
Authors: Dickson Michael 
Published: November 2013

AbstractI explore an agent-based model of the development and dissemination of scientific theory that makes very little use of any pre-defined “social structure” (such as partnerships or collaborations). In these models, under a broad range of values of the parameters, widespread (but not universal) “agreement” about scientific theory emerges. Moreover, the residual disagreement turns out to be important to developing new theories in the face of new evidence.
Collisional effects on the relativistic current-filamentation instability in dense plasmas
Authors: Hao B. , Sheng Z.M. , Zhang J. , Li Y.T. 
Published: November 2013

AbstractCollisional effects on the current-filamentation instability (CFI), accounting for the space charge effect (SCE), are investigated kinetically for a relativistic beam propagating in dense plasmas. It is shown that collisions can completely suppress the SCE in low temperature dense plasma, leading to enhancement of the CFI. This kind of decoupling mechanism is quite different from the well-known resistive mechanism [Molvig (1975).Phys. Rev. Lett.35, 1504]. In particular, we find the present decoupling mechanism can well explain the recent numerical simulation results [Karmakaret al.(2008).Phys. Rev. Lett. doi: 101, 255001]. In the parameter regime related to the laser-solid interaction and fast ignition scenario (FIS), the CFI growth rate with SCE included is enhanced in the low plasma density region through the decoupling mechanism. In the high plasma density region, it is enhanced mainly through the resistive mechanism.
Independent associations of income and education with nutrient intakes in Brazilian adults: 2008–2009 National Dietary Survey
Authors: Araujo Marina Campos , Verly Junior Eliseu , Junger Washington Leite , Sichieri Rosely 
Published: November 2013

AbstractObjectiveTo verify associations of income and education with nutrient intakes in Brazilian adults.DesignData from the population-based National Dietary Survey conducted in 2008–2009. Family per capita income and education levels were categorized into quartiles. Prevalences of inadequate nutrient intakes and excessive intakes of saturated fat and Na were calculated by using the method prescribed by the National Cancer Institute. The Estimated Average Requirement was used as a reference for micronutrient intake. Linear regression models for both the independent and the mutually adjusted associations of education and income with nutrient intakes were tested. Interaction between education and income was tested.SettingHouseholds (n 13 569) selected using a two-stage cluster sampling design.SubjectsFood records for two non-consecutive days were obtained for 21 003 Brazilian adults (aged 20–59 years).ResultsFor most of eleven nutrients, the prevalence of inadequate intake declined with increasing income and education levels; however, it remained high across all income and education quartiles. Excessive intake of saturated fat and low fibre intake increased with both variables. Most nutrients were independently associated with income and education in both sexes. Fe, vitamin B12 and Na intakes among women were associated only with education. There was an interaction between income and education for Na intake in men, P intake in women and Ca intake in both sexes.ConclusionsEducation is one important step to improve nutrient intakes in Brazil. Emphasis should be laid on enhancing dietary knowledge and formulating economic strategies that would allow lower-income individuals to adopt a healthy diet.
When Interdependence Shapes Social Perception: Cooperation and Competition Moderate Implicit Gender Stereotyping
Authors: de Lemus Soledad , Bukowski Marcin 
Published: November 2013

AbstractWe examined the influence of interdependence goals on the accessibility of implicit gender stereotypical associations. Participants were asked to cooperate with or compete against a woman on a mathematical abilities task and subsequently the relative activation of positive and negative warmth and competence traits was measured using a primed categorization task. Results showed that female primes (vs. male primes) facilitated the activation of low warmth and high competence in the competition condition, whereas high warmth was activated in the cooperation condition and no differences were found for competence traits. These results are discussed referring to the stereotype content model and the compensation effect in person perception. The goal dependent nature of implicit gender stereotypes is emphasized.
Therapeutischer Misserfolg in der ambulanten Psychotherapie
Authors: Nelson Nicole E. , Hiller Wolfgang 
Published: November 2013

Theoretischer Hintergrund: Zum Thema therapeutischer Misserfolg in der Psychotherapie fehlen methodisch gut vergleichbare Studien, sodass Forschungsbedarf besteht. Fragestellung: Ziele der vorliegenden Arbeit sind eine Replikation der Studie zur Häufigkeit therapeutischen Misserfolgs von Jacobi, Uhmann und Hoyer (2011) sowie die Erweiterung der Definition therapeutischen Misserfolgs. Methode: Wir analysierten die Daten von 1866 konsekutiven Patienten hinsichtlich Non-Response, Verschlechterung, auffälligen und hoch-symptomatischen Therapieabschlusswerten. Als Messinstrumente kamen der BSI, BDI und der GAF zum Einsatz. Ergebnisse: Verschlechterungen (i. S. einer Untermenge therapeutischen Misserfolgs) traten mit 0.9 – 3.8 % selten auf, therapeutischen Misserfolg fanden wir bei 17.1 % der Stichprobe. Es zeigten sich Zusammenhänge zum Schweregrad der psychopathologischen Belastung und zur Anzahl der vorhandenen Störungen, außerdem fanden sich Störungsbilder bei denen es häufiger zu therapeutischem Misserfolg kam. Schlussfolgerungen: Es bedarf weiterer Studien zur Identifikation von Prädiktoren therapeutischen Misserfolgs.
DoMosaics: software for domain arrangement visualization and domain-centric analysis of proteins
Authors: Moore Andrew D. , Held Andreas , Terrapon Nicolas , Weiner January , Bornberg-Bauer Erich 
Published: November 2013

Abstract
Summary: DoMosaics is an application that unifies protein domain annotation, domain arrangement analysis and visualization in a single tool. It simplifies the analysis of protein families by consolidating disjunct procedures based on often inconvenient command-line applications and complex analysis tools. It provides a simple user interface with access to domain annotation services such as InterProScan or a local HMMER installation, and can be used to compare, analyze and visualize the evolution of domain architectures.
Availability and implementation: DoMosaics is licensed under the Apache License, Version 2.0, and binaries can be freely obtained from www.domosaics.net.
Contact: radmoore@uni-muenster.de or e.bornberg@uni-muenster.de
Uneven Distribution of Zinc in the Dorsal and Ventral Sections of Rice Grain
Authors: Jaksomsak Pennapa , Sangruan Preeyaporn , Thomson Gordon , Rerkasem Benjavan , Dell Bernard , Prom‐u‐thai Chanakan 
Published: November 2013

ABSTRACTThis study examined the distribution of zinc in dorsal and ventral grain sections of rice varieties with low (RD21), moderate (CNT1 and KDML105), and high (KPK and NR) zinc concentrations. Samples of unhusked rice grain were partitioned longitudinally and analyzed for zinc. The concentration of zinc was higher in the dorsal grain section than the ventral section, but to a different extent in different varieties. In unpolished rice, the zinc concentration in the dorsal section exceeded that in the ventral section by 14% in CNT1 to 63% in RD21. The higher zinc concentration in the dorsal section of unpolished rice might be explained by storage in the multiple cell layered aleurone and thicker pericarp. The higher concentration of dorsal zinc, however, was maintained after polishing, irrespective of the removal of grain surface by polishing that varied with variety and polishing time from 11 to 207 μm in depth. Zinc concentration of polished rice, ranging from 14 to 28 mg of zinc/kg, was strongly predicted by the zinc in unpolished rice (P < 0.01). This uneven distribution of zinc in the dorsal and ventral sections of rice grain suggests a specific pattern by which zinc is laid down. Whether the region of endosperm and aleurone proximal to the dorsal vascular bundle may have a greater concentration of zinc transporters and zinc storage structures than in more distal areas is yet to be investigated. Understanding this distribution may aid efforts in zinc biofortification and evaluation of rice varieties for other nutritive characteristics.
First Report of Root-Knot Nematode Meloidogyne enterolobii on Sweet Potato in China
Authors: Gao B. , Wang R. Y. , Chen S. L. , Li X. H. , Ma J. 
Published: November 2013

Sweet potato (Ipomoea batatas Lam.) is the fifth largest staple crop after rice, wheat, maize, and soybean in China. Sweet potato tubers were received from Zhanjiang, Guangdong Province, China, in June 2013 for research purposes. Upon inspection, the storage roots showed typical symptoms of being infected by root-knot nematodes, Meloidogyne spp.; the incidence of infection was 95%. Meloidogyne spp. females and egg masses were dissected from the symptomatic roots. Each root contained about 32 females on average (n = 20). The perineal patterns of most female specimens (n = 10) were oval shaped, with moderately high to high dorsal arch and mostly lacking obvious lateral lines. The second-stage juvenile had large and triangular lateral lips and broad, bluntly rounded tail tip. These morphological characteristics are similar to those reported in the original description of Meloidogyne enterolobii Yang & Eisenback (2). The 28S rRNA D2D3 expansion domain was amplified with primers MF/MR (GGGGATGTTTGAGGCAGATTTG/AACCGCTTCGGACTTCCACCAG) (1). The sequence obtained for this population (n = 5) of Meloidogyne sp. (GenBank Accession No. KF646797) was 100% identical to the sequence of M. enterolobii (JN005864). For further confirmation, M. incognita specific primers Mi-F/Mi-R (GTGAGGATTCAGCTCCCCAG/ACGAGGAACA TACTTCTCCGTCC), M. javanica specific primers Fjav/Rjav (GGTGCGCGATTGAACTGAGC/CAGGCCCTTCAGTGGAACTATAC), and M. enterolobii specific primers Me-F/Me-R (AACTTTTGTGAAAGTGCCGCTG/ TCAGTTCAGGCAGGATCAACC) were used for amplification of the respective DNA sequences (1). The electrophoresis results showed a bright band (~200 bp) only in the lane with the M. enterolobii specific primers. Therefore, this population of Meloidogyne sp. on sweet potato was identified as M. enterolobii based on its morphological and molecular characteristics. M. enterolobii has been reported to infect more than 20 plant species from six plant families: Fabaceae, Cucurbitaceae, Solanaceae, Myrtaceae, Annonaceae, and Marantaceae (1). To our knowledge, this is the first report of M. enterolobii on a member of the Convolvulaceae in China. Refrences: (1) M. X. Hu et al. Phytopathol. 101:1270, 2011. (2) B. Yang and J. D. Eisenback. J. Nematol. 15:381, 1983.
The Cold Signaling Attenuator HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 Activates FLOWERING LOCUS C Transcription via Chromatin Remodeling under Short-Term Cold Stress in Arabidopsis
Authors: Jung Jae-Hoon , Park Ju-Hyung , Lee Sangmin , To Taiko Kim , Kim Jong-Myong , Seki Motoaki , Park Chung-Mo 
Published: November 2013

Abstract
Exposure to short-term cold stress delays flowering by activating the floral repressor FLOWERING LOCUS C (FLC) in Arabidopsis thaliana. The cold signaling attenuator HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 (HOS1) negatively regulates cold responses. Notably, HOS1-deficient mutants exhibit early flowering, and FLC expression is suppressed in the mutants. However, it remains unknown how HOS1 regulates FLC expression. Here, we show that HOS1 induces FLC expression by antagonizing the actions of FVE and its interacting partner histone deacetylase 6 (HDA6) under short-term cold stress. HOS1 binds to FLC chromatin in an FVE-dependent manner, and FVE is essential for the HOS1-mediated activation of FLC transcription. HOS1 also interacts with HDA6 and inhibits the binding of HDA6 to FLC chromatin. Intermittent cold treatments induce FLC expression by activating HOS1, which attenuates the activity of HDA6 in silencing FLC chromatin, and the effects of intermittent cold are diminished in hos1 and fve mutants. These observations indicate that HOS1 acts as a chromatin remodeling factor for FLC regulation under short-term cold stress.
Adolescent food literacy programmes: A review of the literature
Authors: Brooks Natalie , Begley Andrea 
Published: November 2013

AbstractAimThe aim of this study was to explore what is known about food literacy programmes targeting adolescents, including identification of the constituents of food literacy addressed, assessment of programme effectiveness, and description of programme design or delivery specific to adolescents.MethodsA review of the peer‐reviewed literature surrounding adolescent food literacy was conducted using scholarly electronic databases. Programme reports were identified in the grey literature using online searching and cross‐referencing to support the research aim. Programmes from 2000 to 2012 targeting adolescents aged 13–17 years were included.ResultsA total of 19 peer‐reviewed papers and four grey literature programmes met the search criteria. Interventions focused on practical cooking and/or food preparation skills and targeted younger adolescent age groups. Programmes were most commonly held in schools and community settings. The majority of programmes (n = 16/23) did not use a theoretical basis for their development. Programme evaluation encompassed the use of pre‐ and post‐intervention questionnaires and focus groups. Only nine studies included a dietary behaviour‐based outcome measure. Although 19 of the 23 studies reviewed reported positive changes related to the intervention, these did not include significant changes in diet quality or cooking frequency at home.ConclusionsFew existing adolescent food literacy programmes have demonstrated a positive impact on dietary behaviours to date. Adolescent target groups present unique challenges in programme development and delivery. However, the physical, social and emotional health needs of this age group and potential to influence lifelong behaviours highlight the need to design effective and age‐appropriate adolescent food literacy programmes.
Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab‐Indian haplotype is not benign
Authors: Alsultan Abdulrahman , Alabdulaali Mohammed K. , Griffin Paula J. , AlSuliman Ahmed M. , Ghabbour Hazem A. , Sebastiani Paola , Albuali Waleed H. , Al‐Ali Amein K. , Chui David H. K. , Steinberg Martin H. 
Published: November 2013

SummarySickle cell disease (SCD) in Saudi patients from the Eastern Province is associated with the Arab‐Indian (AI) HBB (β‐globin gene) haplotype. The phenotype of AI SCD in children was described as benign and was attributed to their high fetal haemoglobin (HbF). We conducted a hospital‐based study to assess the pattern of SCD complications in adults. A total of 104 patients with average age of 27 years were enrolled. Ninety‐six per cent of these patients reported history of painful crisis; 47% had at least one episode of acute chest syndrome, however, only 15% had two or more episodes; symptomatic osteonecrosis was reported in 18%; priapism in 17%; overt stroke in 6%; none had leg ulcers. The majority of patients had persistent splenomegaly and 66% had gallstones. Half of the patients co‐inherited α‐thalassaemia and about one‐third had glucose‐6‐phosphate dehydrogenase deficiency. Higher HbF correlated with higher rate of splenic sequestration but not with other phenotypes. The phenotype of adult patients with AI SCD is not benign despite their relatively high HbF level. This is probably due to the continued decline in HbF level in adults and the heterocellular and variable distribution of HbF amongst F‐cells.
Internalization routes of cell‐penetrating melanoma antigen peptides into human dendritic cells
Authors: Buhl Timo , Braun Andrea , Forkel Susann , Möbius Wiebke , van Werven Lars , Jahn Olaf , Rezaei‐Ghaleh Nasrollah , Zweckstetter Markus , Mempel Martin , Schön Michael P. , Haenssle Holger A. 
Published: November 2013

AbstractOptimized delivery of antigens combined with sustainable maturation of dendritic cells (DCs) is crucial for generation of effective antitumoral immune responses. Multiple approaches for ex vivo antigen loading and improvement in immunogenicity have been described. We have recently established a single‐step protocol consisting of a fusion peptide (a sequence of the melanoma antigen Melan‐A and a cationic cell‐penetrating HIV TAT domain) bound in complexes with a toll‐like receptor agonist. As the exact cellular uptake mechanisms of TAT‐coupled antigens have been a matter of considerable debate and significantly depend on cell type, cargo and concentrations, we evaluated internalization routes into human immature DCs in comparison with non‐phagocytic cell lines. We found that Melan‐A‐TAT fusion peptide uptake by DCs is mainly energy dependent, superior compared with polylysine‐coupled Melan‐A and significantly higher in DCs as compared with Jurkat cells or HUVECs. Furthermore, we could track the uptake of the fusion peptide exclusively through early endosomes to lysosome compartments after 90 min by fluorescence microscopy and immunoelectron microscopy. Specific endocytosis inhibitors revealed major internalization of the fusion peptide by DCs via clathrin‐mediated endocytosis, whereas uptake by non‐phagocytic HUVECs differed significantly, involving macropinocytosis as well as clathrin‐mediated endocytosis. As our understanding of the processes involved in internalization of TAT‐coupled cargos by human DCs broadens, and DC activation becomes available by single‐step procedures as described, further development of simultaneous DC maturation and intra‐cellular peptide targeting is warranted.
Vitalist strategies in contemporary Western herbal medicine
Authors: Hiller Sabine 
Published: November 2013

AbstractVitalism has long been discredited and considered superfluous in the life sciences. How does contemporary Western herbal medicine (CWHM) justify its continued adherence to vitalism? While the appeals made to philosophy, science and complexity theory by CWHM authors are unsuccessful, vitalism plays an important role in providing a distinct professional identity.