bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tyrosine kinase inhibitors in the treatment of leptomeningeal carcinomatosis
Authors: Ni Hanyu , Wang Zilan , Tang Yanbing , Lu Jiaye , Zhu Zixiang , Qiu Youjia , Chen Zhouqing , Wang Zhong 
Published: August 2024

AbstractLeptomeningeal carcinomatosis (LMC) is a devastating complication of advanced cancers, such as lung cancer and breast cancer, which is usually indicative of a poor prognosis. The current treatments for LMC include palliative care, with others aiming to prolong survival and relieve neurological symptoms. Traditional treatments for LMC include radiotherapy, systemic chemotherapy, and intrathecal injection. Furthermore, the application of molecularly targeted agents, such as antiepidermal growth factor receptor (anti‐EGFR), antihuman epidermal growth factor receptor 2 (anti‐HER2), and anti‐PD‐1 monoclonal antibody, have prolonged the survival of LMC patients. Targeted therapy with tyrosine kinase inhibitors has also been proven to be an effective treatment. Tyrosine kinases can be overactive or expressed at high levels in some cancer cells; therefore, the use of tyrosine kinase inhibitors may prevent the activation of tumor‐related pathways, preventing cancer cell growth. The EGFR family are cell surface receptors directly related to tumor occurrence with tyrosine kinase activity; it is the most widely used target for tyrosine kinase inhibitors in the treatment of LMC. In this review, we introduced the clinical manifestation and diagnostic criteria of LMC, clarified the treatment mechanism of tyrosine kinase inhibitors for LMC with mutations in EGFR, HER2, or anaplastic lymphoma kinase, reviewed the current application of various generation tyrosine kinase inhibitors in patients with LMC, and discussed new clinical trials and the future directions of tyrosine kinase inhibitor therapy.
Structural Deformations in Cucurbit[n]urils: Analysis, Host‐Guest Dependence, and Automated Ellipticity Measurements Using ElliptiCB[n]
Authors: Garcia Arman C. , Shavlik Michael , Harms Michael J. , Pluth Michael D. 
Published: August 2024

AbstractCucurbit[n]urils (CB[n]s) are cyclic macrocycles with rich host‐guest chemistry. In many cases, guest binding in CB[n]s results in host structural deformations. Unfortunately, measuring such deformations remains a major challenge, with only a handful of manual estimations reported in the literature. To address this challenge, we have developed the public program ElliptiCB[n], which is available on GitHub, that provides a robust and automated method for measuring the elliptical deformations in CB[n] hosts. We outline the development and validation of this approach, apply ElliptiCB[n] to measure the ellipticity of the 1113 available CB[n] structures from the Cambridge Structural Database (CSD), and directly investigate the structural deformations of CB[5], CB[6], CB[7], CB[8], and CB[10] hosts. We also report the general landscape of accessible CB[n] elliptical deformations and compare ellipticity distributions across CB[n] hosts and host‐guest complexes. We found that in almost all cases guest binding significantly impacts the distribution of host ellipticity distributions and that these distributions are dissimilar across host‐guest complexes of differently sized CB[n]s. We anticipate that this work will provide a useful approach for understanding of the flexibility of CB[n] hosts and will also enable future measurement and standardization of ellipticity measurements of CB[n]s.
Dual, Photo‐Responsive and Redox‐Active Supramolecular Foldamers
Authors: Davis Alexander R. , Dismorr Jack O. , Male Louise , Tucker James H. R. , Pike Sarah J. 
Published: August 2024

AbstractWe report on dual, light‐responsive and redox‐active foldamers that demonstrate reversible and robust stimuli‐induced behaviour. Herein, UV/Vis, 1H NMR and circular dichroism (CD) spectroscopy and cyclic voltammetry have been used to establish the reversibility and highly robust nature of the light‐ and redox‐driven behaviour of these new foldamers with minimal levels of fatigue observed even upon multiple cyclic treatments with irradiative/non‐irradiative and oxidative/reductive conditions. This proof‐of‐concept work paves the way towards the creation of novel stimuli‐responsive foldamers of increasing sophistication capable of demonstrating reversible and robust responses to multiple distinct stimuli.
Formate‐Mediated Synthesis of β‐Hydroxysulfides from Olefins and Thiosulfonates via EDA Complex Strategy under Visible Light Irradiation in Air
Authors: Shen Qing , Peng Xiaoyan , Sui Jiahong , Peng Min , Liu Xiangwei , Jiang Hezhong , Tan Rui , Zhou Min , Li Jiahong 
Published: August 2024

Comprehensive SummaryA visible‐light‐induced and efficient one‐pot synthesis of β‐hydroxysulfides from olefins, thiosulfonates and HCOOCs using an EDA complex strategy under air atmosphere at room temperature has been disclosed. A plausible radical involved mechanism is proposed. During the reaction process, formates play a crucial role: first, as donors in the EDA complex; second, as providers of the hydrogen source; and third, by generating CO2•– to reduce peroxide intermediates, leading to the formation of β‐hydroxysulfides. In contrast to the previously reported thiol‐oxygen co‐oxidation reactions, this simple and sustainable approach features mild reaction conditions, operational simplicity, odorless and excellent functional group tolerance.
Non‐Covalent Immobilization of Chiral Rhodium Catalysts on Carbon Nanotubes for Asymmetric Hydrogenation
Authors: Arora Zinnia , Rais Meriem , Pârvulescu Vasile I. , Philippot Karine , Durand Jérôme , Gouygou Maryse 
Published: August 2024

AbstractSupported chiral catalysts were prepared by ionic anchoring of two cationic rhodium complexes (A and B) onto functionalized carbon nanotubes (CNTs). The immobilization of the Rh complexes was done by applying two ionic anchoring strategies: i) electrostatic interaction with the negatively charged surface of carboxylate‐functionalized CNTs (CNT‐COO−); ii) electrostatic interaction through a heteropoly acid (HPA) spacer previously grafted at the CNTs surface (CNT‐HPA). The characterization of the obtained CNT‐COO−@complex A, CNT‐COO−@complex B, CNT‐HPA@complex A, and CNT‐HPA@complex B materials by ICP, TEM and XPS showed the successful anchoring of the Rh complexes onto the supports. The HPA spacer was found to increase the catalyst's stability and to limit the effect of the CNT surface on the catalytic performances of the immobilized Rh complexes. CNT‐HPA@complexes performed the hydrogenation of dimethyl itaconate into methyl succinate with high conversions (83–100 %) and good enantioselectivities (58–63 %). The recyclability tests showed the catalysts were less active but still enantioselective after recycling.
Theoretical Description of Hydride‐hydride Interactions in Selected Hydrogen Storage Materials
Authors: Ptaszek Aleksandra L. , Sagan Filip , Filas Radosław , Kubisiak Piotr , Mitoraj Mariusz P. 
Published: August 2024

AbstractIn recent years there has been growing interest in the use of metal hydrides as hydrogen rich sources. The high content of hydride‐hydride contacts Hδ−⋅⋅⋅δ−H in these materials appears to be relevant for hydrogen formation. At present time there is no consensus whether these contacts are attractive or repulsive. Accordingly, the main goal of this article is to shed light on physical factors which constitute homopolar hydride‐hydride interactions Hδ−⋅⋅⋅δ−H in selected transition metal complexes i. e. HCoL4, L=CO,PPh3,PH3. In order to achieve this goal, the charge and energy decomposition ETS‐NOCV approach along with the Interacting Quantum Atoms (IQA) and reduced density gradient (NCI) are applied for the bonded adducts L4CoH⋅⋅⋅HCoL4. Based on DFT and correlated methods it has been shown, contrary to classical interpretations, that hydride‐hydride interactions might be attractive and even far stronger than classical hydrogen bonds. The stability of the adducts is increased by phosphine ligand installation: overall Hδ−⋅⋅⋅δ−H bonding energy changes in the order: CO≪PPh3~PH3. It has been revealed that depending on monomer's conformations Hδ−⋅⋅⋅δ−H bonds are dominated by charge delocalization or London dispersion forces and the electrostatic term is also relevant. The side carbonyl ligands additionally stabilize the Hδ−⋅⋅⋅δ−H bonded structures through covalent charge delocalizations and Coulombic contributors. Furthermore, the sterically crowded systems containing bulky phosphine ligands are supported by π⋅⋅⋅π stacking, C−H⋅⋅⋅π and C−H⋅⋅⋅H−Co. It is finally determined by IQA energy decomposition, that diatomic hydride‐hydride interaction CoH⋅⋅⋅HCo is chameleon‐like, namely, it is attractive in CO4CoH⋅⋅⋅HCoCO4 and (PH3)4CoH⋅⋅⋅HCo(PH3)4, whereas the repulsion is unveiled in (CO)3(PPh3)CoH⋅⋅⋅HCo(CO)3(PPh3) where the monomers are of Cs symmetry.
Dye‐Containing Polymers with π‐Extened Diketopyrropyrrole Derivatives for Semi‐Transparent Organic Photovoltaics
Authors: Nishiyama Tomoki , Yamaoka Taiki , Nakajima Kento , Weng Weichun , Nakano Sota , Yamamoto Taro , Tanaka Senku , Wakabayashi Tomonari , Suzuki Hal , Kitoh‐Nishioka Hirotaka , Okubo Takashi 
Published: August 2024

AbstractDye‐containing polymers P1 (PEDPP‐OT‐BDT) and P2 (PEDPP‐OT‐BDTT) including a π‐extended diketopyropyrrole (DPP) derivative and electron‐rich thiophene fused ring units (4,8‐bis((2‐ethylhexyl)oxy)benzo[1,2‐b:4,5‐b′]dithiophene for P1 and 4,8‐bis(5‐(2‐ethylhexyl)thiophen‐2‐yl)benzo[1,2‐b:4,5‐b′]dithiophene for P2) were synthesized as narrow band gap dyes. A π‐extended DPP (EDPP‐OT‐BrPh), fragment of the polymers P1 and P2, was obtained by extending the π‐conjugation of DPP using Ru(III)‐catalyzed C−H and N−H activation reported by Gońka et al. in 2019, exhibiting a high quantum yield (ϕem=0.84) and small HOMO‐LUMO gap (Eg=1.69 eV) due to the spatial overlap of the HOMO and LUMO orbitals. The solubility of the π‐extended DPP was improved by introducing four 2‐octylthophene side chains around the periphery of the planer dye moiety, while maintaining the high planarity of the dye molecule, which is essential to the function of optoelectronic devices. As a result, P1 and P2, polymerized with the π‐extended DPP and BDT derivatives, exhibit carrier mobility of approximately 10−5 cm2/Vs in organic field‐effect transistors (OFETs). In bulk heterojunction (BHJ) solar cells with [6,6]‐phenyl‐C61‐butyric acid methyl ester (PCBM), they demonstrate a power conversion efficiency (PCE) of 1.0 % with an average transmittance (AVTs) of around 60 %.
Impact of corporate social responsibility on consumer retention and satisfaction with moderation of consumer social responsibility drawing on stakeholder theory analysis
Authors: Jiang He , Fang Wei 
Published: August 2024

AbstractHow corporate social responsibility (CSR) and consumer social responsibility (CnSR) can perform a preeminent role in satisfying and retaining consumers is an unprecedented research gap that needs to be uncovered in the existing literature. This study explores the multidimensional associations of CSR on consumers' satisfaction (CS) and consumer retention (CR) along with moderation of CnSR from a developing economy using rigorous empirical analysis within small and medium‐sized enterprises (SMEs) in China. The findings affirmed the positive nexus of CSR on CS and CR. The results asserted the significant moderating impact of CnSR among CSR, CR, and CS. These results yield insights for the management to reshape strategies by understanding social responsibility perspectives on both sides to align corporate and consumers' interests. Additionally, how the inclusion of CSR practices can bridge the gap between corporations and consumers is another unique contribution of this study. Finally, the paper confers interesting and valuable implications along with lines for future work.
Electrochemical Kinetics of LiFePO4 Cathode Material in Non‐flammable Inorganic Liquid Electrolyte
Authors: Ramar Vishwanathan , Pszolla Christian , Weinberger Manuel , Borck Markus , Zinck Laurent 
Published: August 2024

AbstractWe unveil the fundamental insights of electrochemical kinetics of LFP cathode material and the passivation layer formation in the SO2‐based non‐flammable inorganic liquid electrolyte (IE). The influence of temperature and electrochemical potential cutoff in the electrochemical activity of LFP cathode and IE is disclosed. Furthermore, the materials compatibility, structural and chemical stability of LFP in IE is demonstrated using very slow galvanostatic cycling in combination with LiFePO4||Li0.1FePO4 symmetric cells. The lithium storage performance of LFP half‐cell using inorganic electrolyte is presented with the optimum voltage window. LFP half‐cells exhibit discharge capacities of 147, 111, and 75 mAh/g at 1, 4, 8 C rates, respectively, with coulombic efficiencies of ~99.98 %. The electrochemical behavior and mechanism of LFP||Graphite cell in IE is investigated while concurrently tracking the electrochemical potentials of LFP and Graphite half‐cell.
Hybrid Red Deer and Improved Fireworks Optimization Algorithm–based Clustering Protocol for improving network longevity with energy stability in WSNs
Authors: Anupkant Sabnekar , Yugandhar Garapati 
Published: August 2024

SummaryClustering of nodes in wireless sensor networks (WSNs) plays a dominant role in gathering environmental data from the specific area of monitoring over which they are deployed for achieving a reactive decision‐making process. The design and development of an energy‐efficient clustering strategy with a potential cluster head (CH) selection process is a herculean task. This development of the CH selection scheme is referred as a non‐deterministic polynomial (NP) hard problem as it needs to optimize different parameters that influence the selection of potential sensor nodes as CH. It needs to concentrate on the process of enhancing network lifespan with energy efficiency by selecting optimal routing path during data dissemination activity. In this paper, a Hybrid Red Deer and Fireworks Optimization Algorithm (HIRDIFOA)–based energy efficient clustering technique is proposed for extending network lifespan with maximized stability in the network energy. This proposed HRDFOA integrated the exploration capability of Improved Red Deer Optimization (IRDOA) with the maximized exploitation tendency of the Modified Firework Optimization Algorithm (MFWOA) during the CH selection process. It facilitated the CH selection by evaluating the fitness functions that integrate the factors of residual energy (RE), distance between sensor and CH, distance between CH and sink, and radius of communication. It significantly adopted MWFOA for achieving sink node mobility such that data can be reliably routed from CH to sink. The outcomes of HRDFOA confirm better throughput of 19.21% with reduced energy consumption of 17.42% and reduced end‐to‐end delay of 18.52% in contrast to the competitive CH selection schemes used for investigation.
A Retrospective Cytomorphologic Analysis of Salivary Gland Fine Needle Aspirates Classified as Salivary Gland Neoplasm of Uncertain Malignant Potential: A 6‐year Institutional Experience
Authors: Agarwal Shweta 
Published: August 2024

ABSTRACTBackgroundThe Milan System for Reporting Salivary Gland Cytopathology is an effective reporting system for salivary gland fine needle aspirations with well‐established risks of malignancy. Salivary gland neoplasm of uncertain malignant potential (SUMP) comprises a heterogenous group of lesions which have features that can be recognized as at least neoplastic but preclude further classification into benign or malignant. In this study, we reviewed the cytomorphologic features of salivary gland fine needle aspirations diagnosed as SUMP at our institution (over the past 6 years) and correlated those with the final diagnosis on surgical follow up.DesignA retrospective search was performed to identify cases classified as SUMP at our institution from January 2018 to February 2024. Cytology slides were reviewed, and cases were subclassified based on key cytomorphologic features into the following categories: (1) basaloid, (2) oncocytic, (3) with clear cell features and (4) mixed features (myoepithelial/oncocytoid/squamoid features). Histologic diagnosis was recorded if available.ResultsA total of 36 cases of SUMP were identified; 31/36 had surgical follow up; final diagnosis included 22 benign lesions (2 non‐neoplastic and 20 benign neoplasms), and nine malignant lesions. The overall risk of neoplasm and risk of malignancy were 93.5% and 29% respectively, with the oncocytic sub‐category recording the highest ROM (42.8%). Mucoepidermoid carcinoma was the most common malignant diagnosis and pleomorphic adenoma the most common benign diagnoses.ConclusionsOur study supports the subclassification of SUMP lesions based on key cytomorphologic features, thereby aiding in refining this ambiguous entity and providing a precise risk assessment.
Bimodal spore release heights in the water column enhance local retention and population connectivity of bull kelp, Nereocystis luetkeana
Authors: Burnett Nicholas P. , Ricart Aurora M. , Winquist Tallulah , Saley Alisha M. , Edwards Matthew S. , Hughes Brent , Hodin Jason , Baskett Marissa L. , Gaylord Brian 
Published: August 2024

AbstractDispersal of reproductive propagules determines recruitment patterns and connectivity among populations and can influence how populations respond to major disturbance events. Dispersal distributions can depend on propagule release strategies. For instance, the bull kelp, Nereocystis luetkeana, can release propagules (spores) from two heights in the water column (“bimodal release”): at the water surface, directly from the reproductive tissues (sori) on the kelp's blades, and near the seafloor after the sori abscise and sink through the water column. N. luetkeana is a foundation species that occurs from central California to Alaska and is experiencing unprecedented levels of population declines near its southern range limit. We know little of the kelp's dispersal distributions, which could influence population recovery and restoration. Here, we quantify how bimodal spore release heights affect dispersal outcomes based on a numerical model specifically designed for N. luetkeana. The model incorporates oceanographic conditions typical of the species' coastal range and kelp biological traits. With bimodal release heights, 34% of spores are predicted to settle within 10 m of the parental alga and 60% are predicted to disperse beyond 100 m. As an annual species, bimodal release heights can facilitate the local regeneration of adults within a source kelp forest while also supporting connectivity among multiple forests within broader bull kelp metapopulations. To leverage this pattern of bimodal spore dispersal in bull kelp restoration management, directing resources toward strategically located focal populations that can seed other ones could amplify the scale of recovery.
Isothiocyanates attenuate heparin‐induced proliferation of colon cancer cells in vitro
Authors: Zhang Yizi , Saha Karabi , Nandani Raj , Yuan Jiahui , Dey Moul , Gu Zhengrong 
Published: August 2024

AbstractIsothiocyanates (ITCs), prevalent in cruciferous vegetables, are known for their anticarcinogenic properties. Prior research has indicated that heparin can stimulate the growth of colon cancer cells. However, the implications of ITCs in the diet of cancer patients receiving heparin‐based therapies have yet to be fully understood. This exploratory in vitro study examines the proliferative effects of low‐molecular‐weight heparin (LMWH) on human colon cancer cells and assesses the antiproliferative potential of four ITC compounds, exploring possible epidermal growth factor family of receptor tyrosine kinases (Erb‐B) related mechanisms. We evaluated cell viability in HCT‐116 and HT‐29 cell lines following treatment with ITCs alone or combined with LMWH (20 μg/mL) at various concentrations (1–100 μM). Clonogenic and wound‐healing assays were performed after 24 h of treatment with 5 μM ITCs. Additionally, messenger RNA (mRNA) and protein expression of Erb‐B family genes was measured using quantitative polymerase chain reaction (qPCR) and Western blotting. Statistical analysis was conducted using analysis of variance (ANOVA) with Dunnett's post hoc test. Results indicated that the half‐maximal inhibitory concentration (IC50) values for Phenylethyl isothiocyanate (PEITC), Benzyl isothiocyanate (BITC), and Sulforaphane (SFN) were lower than those of Allyl isothiocyanate (AITC) in LMWH‐stimulated HCT‐116 (20.77, 19.10, and 44.05 μM, respectively) and HT‐29 (74.94, 26.77, and 43.49 μM, respectively). PEITC and SFN significantly reduced ErbB1 (epidermal growth factor receptor (EGFR)) and ErbB4 (receptor tyrosine‐protein kinase erbB‐4) expression, while BITC decreased ErbB2 (receptor tyrosine‐protein kinase erbB‐2) and transforming growth factor beta (TGF‐β) expression in HCT‐116 cells (all, p < .05). PEITC, BITC, and SFN also increased proapoptotic Bax expression and decreased the antiapoptotic B‐cell lymphoma 2 (Bcl‐2) expression (all, p < .05). These findings suggest that specific ITCs may mitigate cancer cell proliferation induced by LMWH in cancer therapies, highlighting their potential therapeutic efficacy.
Investor Sentiment, Unexpected Inflation, and Bitcoin Basis Risk
Authors: Conlon Thomas , Corbet Shaen , Oxley Les 
Published: August 2024

ABSTRACTThe introduction of regulated CME futures contracts on Bitcoin in 2017 raised an expectation that cryptocurrencies would become part of mainstream financial markets. This also heightened links between traditional markets and Bitcoin, implying that the cryptocurrency would be subject to systematic spillovers. This paper uses high‐frequency data to examine whether Bitcoin basis risk is linked to investor sentiment from established financial markets. Our findings indicate that extreme investor sentiment, as reflected by the tail risk in various volatility indices, including the VIX, consistently correlates with a negative Bitcoin basis, where Bitcoin futures prices are lower than spot prices. Fluctuations significantly influence this relationship in the trading volume of Bitcoin futures and are more pronounced during periods of substantial unexpected inflation and deflation. These results underline the complex dynamics between market sentiment and cryptocurrency pricing, offering insights with substantial implications for investors and policymakers.
Theranostic scope of monometallic selenium and titanium dioxide nanoparticles in biomedicine: A review
Authors: Nagarajan Shwetha B. , Jayaraman Anuradha , Ramakrishnan Sanjeevi 
Published: August 2024

AbstractThe nanoparticles (NPs) of metals and metal oxides constitute significant components of technology in terms of monometallic NPs (MNPs). Over the last decade, the most fascinating and in‐depth uses of NPs have been found in the biomedical field, which has demonstrated the therapeutic potential of these particles. Significant strides have been made in the application of nanotechnology across various industries, including biomedical sciences. In biomedicine, two of the most important applications of NPs are in the diagnosis and treatment of disease. Given their ability to deliver specific drugs, these next‐generation NPs provide safe and effective pharmacotherapies for a wide range of disorders. Selenium nanoparticles (SeNPs) and titanium dioxide (TiO2) NPs offer potential treatments for various applications, including hair care and cancer treatment. SeNPs help with abiotic stress, plant disease, and growth, while TiO2 NPs enhance bio‐imaging and drug delivery. This comprehensive review focuses on MNPs like Se (metal‐based) and TiO2 (metal‐oxide based). It covers their synthesis methods, nanoscale physicochemical properties, and the definition of specific industrial applications in various fields of applied nanotechnology, including biomedicine.