bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Do Right‐to‐Work Laws Do? Evidence from a Synthetic Control Method Analysis
Authors: Eren Ozkan , Ozbeklik Serkan 
Published: July 2015

AbstractUsing the case study of Oklahoma and a recently developed econometric technique, we examine the impact of right‐to‐work (RTW) laws on state‐level labor market outcomes. Our results show that the passage of RTW laws in Oklahoma decreased private sector unionization rates. Several other state outcomes including total employment rate and private sector average wages, on the other hand, were not affected by RTW laws. The findings for the private sector generally carry over to the manufacturing sector.
Inferior vena cava (IVC) filters in children: A 10‐year single center experience
Authors: Rottenstreich Amihai , Revel‐Vilk Shoshana , Bloom Allan I. , Kalish Yosef 
Published: July 2015

BackgroundVenous thromboembolism (VTE) is an increasingly recognized problem among children and adolescents. Although inferior vena cava (IVC) filter placement for pulmonary embolism prevention is well reported in adults, data regarding safety and efficacy in the pediatric age group are lacking.ProcedureAt a large university hospital with a level I trauma center, medical records of children and adolescents who underwent IVC filter insertion were reviewed. Appropriateness of referral for retrieval was assessed in each case.ResultsFifty‐nine children and adolescents (mean age 16 years) successfully underwent IVC filter insertion. All filters placed were retrievable. In 47 patients (79.7%), prophylactic filters were placed in the absence of acute VTE in the setting of trauma. In eight patients (13.5%), filters were placed due to contraindication to anticoagulation therapy with concomitant lower extremity deep vein thrombosis or pulmonary embolism. Filters were successfully retrieved in only 12 patients (20.3%), although an attempt at removal was appropriate and feasible in over 90% of cases. Mean duration of follow‐up was 2.1 (range 0.4–7.3) years. A significantly higher retrieval rate was found in patients followed at our thrombosis clinic (P < 0.01). Ten patients (17%) experienced at least one filter‐related complication.ConclusionsAlthough in most cases, IVC filters were placed for prophylactic indications, the evidence to support their role in this setting is limited. Their low retrieval rate and high filter‐related complication rate question their extensive utilization in children. Dedicated follow‐up is necessary to detect complications and to ensure that an attempt at retrieval is made when feasible. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Strategic planning as a complex and enabling managerial tool
Authors: Arend Richard J. , Zhao Y. Lisa , Song Michael , Im Subin 
Published: July 2015

Research summary: The role of the strategic planning process in the ongoing generation of innovative knowledge is vital to the survival and growth of a firm, especially when technologies and market conditions are rapidly changing. We analyze data from a survey of firms in high‐technology industries to determine whether it is possible to break the commonly experienced trade‐off between strategic planning's positive influence on firm profitability and its negative influence on firm innovation. We draw on Adler and Borys's (1996) conceptualization of bureaucratic process types to identify several firm characteristics that have the potential to affect whether employees perceive strategic planning as enabling to their creative endeavors. We find that contingent effects between strategic planning and the identified firm characteristics exist that can break the trade‐off.Managerial summary: A tension exits in the literature about whether strategic planning hurts or helps innovative activity. Our analysis of data from 227 business units in high‐technology industries indicates that strategic planning is a complex process that can be perceived by employees as enabling or coercive. Our results confirm that strategic planning negatively affects innovative activity but positively affects profitability for average firms. We find, however, controllable firm characteristics—risk‐taking and knowledge‐based reward systems—affect the trade‐off. Given the higher levels of risk‐taking and knowledge‐based reward systems, firms can use strategic planning to achieve both high returns on investment and a high level of innovative activity. Copyright © 2015 John Wiley & Sons, Ltd.
Assessing traceability—practical experiences and lessons learned
Authors: Regan Gilbert , Biro Miklos , Flood Derek , McCaffery Fergal 
Published: July 2015

AbstractMost existing software systems that lack explicit traceability links between artefacts, or if implemented, are often not leveraged to take advantage of the information it can provide to a development or validation team.Within the medical device domain, as in other safety critical domains, regulation normally requires such systems that are certified before entering service. This involves submission of a safety case (a reasoned argument that the system is acceptably safe) to the regulator. A safety case should include evidence that the organisation has established effective software development processes. At the heart of such processes, they must incorporate traceability.However, numerous barriers such as a lack of awareness of traceability and a lack of guidance as to how to implement traceability hamper its effective implementation. In this paper, we address the lack of guidance on traceability implementation by presenting our experience of developing and trialling a traceability assessment model in two medical device organisations. We show that the assessment model was successful in identifying strengths and weaknesses in both organisations' implementation of traceability. Through experience of trialling the model, we propose an idea to improve it by automation, using the Open Services for Lifecycle Collaboration initiative. Copyright © 2015 John Wiley & Sons, Ltd.
Alpha‐phellandrene‐induced apoptosis in mice leukemia WEHI‐3 cells in vitro
Authors: Lin Jen‐Jyh , Hsu Shu‐Chun , Lu Kung‐Wen , Ma Yi‐Shih , Wu Chih‐Chung , Lu Hsu‐Feng , Chen Jaw‐Chyun , Lin Jaung‐Geng , Wu Ping‐Ping , Chung Jing‐Gung 
Published: July 2015

ABSTRACTAlthough reports have shown that α‐phellandrene (α‐PA) is one of the monoterpenes and is often used in the food and perfume industry, our previous studies have indicated that α‐PA promoted immune responses in normal mice in vivo. However, there is no available information to show that α‐PA induced cell apoptosis in cancer cells, thus, we investigated the effects of α‐PA on the cell morphology, viability, cell cycle distribution, and apoptosis in mice leukemia WEHI‐3 cells in vitro. Results indicated that α‐PA induced cell morphological changes and decreased viability, induced G0/G1 arrest and sub‐G1 phase (apoptosis) in WEHI‐3 cells. α‐PA increased the productions of reactive oxygen species (ROS) and Ca2+ and decreased the levels of mitochondrial membrane potential (ΔΨm) in dose‐ and time‐dependent manners in WEHI‐3 cells that were analyzed by flow cytometer. Results from confocal laser microscopic system examinations show that α‐PA promoted the release of cytochrome c, AIF, and Endo G from mitochondria in WEHI‐3 cells. These results are the first findings to provide new information for understanding the mechanisms by which α‐PA induces cell cycle arrest and apoptosis in WEHI‐3 cells in vitro. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1640–1651, 2016.
Synthesis, Structures, and Luminescent Properties of Three Coordination Polymers Constructed from Tricarboxylate and Bisbenzoimidazole Ligand
Authors: Wen Yong‐Hong , Wang Dong‐Mei , Wen Hui‐Ling , Zhang Yue , Yao Kuo 
Published: July 2015

AbstractThe hydrothermal reaction of the tricarboxylate ligand 5‐(carboxymethoxy)isophthalic acid (H3L) with ZnII, CdII, and SnII salts in the presence of the bisbenzoimidazole coligand 1, 3‐bis(benzimidazol‐2‐yl)‐2‐oxapropane (bbop) afforded the coordination polymers, [Zn(HL)(bbop)]n (1), [Cd(HL)(bbop)]n (2), and {[H2(bbop)][Sn2L2]}n (3). The complexes were characterized by elemental analyses, IR spectroscopy, single‐crystal X‐ray diffraction analyses, thermogravimetric analyses, and fluorescence properties. The structures of complexes 1 and 2 are constructed by 1D chains and show strong blue luminescence emission. The structure of complex 3 is a 2D anionic dilayer, and shows a vase‐like porous structure occupied by the bulky [H2(bbop)]2+ cation, which is an uncommon structural feature in transition metal coordination polymers. The three complexes are further connected by hydrogen bonds to form 3D supramolecular architectures.
Hydrothermal Syntheses, Crystal Structures, and Luminescent Properties of Two Zinc(II) Coordination Polymers
Authors: Liu Haiyan , Jia Anqiang , Wang Zichen , Zhang Lihui 
Published: July 2015

AbstractTwo zinc(II) compounds, namely [Zn5(AmTAZ)6(OH)2]n·2n(NO3)·6n(H2O) (1) and [Zn3(AmTAZ)2(mal)2]n (2) (HAmTAZ = 3‐amino‐1,2,4‐triazole, H2mal = malonic acid), were hydrothermally synthesized and characterized by elemental analysis, IR spectroscopy, and X‐ray diffraction. Single crystal X‐ray diffraction analysis reveals that compound 1 features a 3D framework with dodecahedral cages occupied by free nitrate ions and lattice water molecules and can be reduced into a (4, 8)‐connected flu topological network. Compound 2 features a 3D framework based on two different 1D chains. Moreover, the thermal stabilities and luminescent properties of compounds 1 and 2 were investigated.
Hypercholesterolemia Induced Immune Response and Inflammation on Progression of Atherosclerosis in Apobtm2SgyLdlrtm1Her/J Mice
Authors: Rao Lakshmi Narasimha , Ponnusamy Thiruvelselvan , Philip Sheena , Mukhopadhyay Rupak , Kakkar Vijay V. , Mundkur Lakshmi 
Published: July 2015

AbstractThe effect of hypercholesterolemia induced immune response and inflammation on progression of atherosclerosis in ApoBtm25gyLDLrtm1Her mice, expressing only ApoB100 and deficient in the low density lipoprotein (LDL) receptor, thus closely resembling human cholesterol transport is not well defined. Atherosclerosis was induced by a high cholesterol diet and its progression was studied at 8, 14 and 20 weeks. Antibody response was determined by ELISA. Lymphocytes in spleen and aortic expression of inflammatory markers were studied by flow cytometry, and immunohistochemistry respectively. A rapid increase in plasma LDL levels in the first 8 weeks was followed by the exponential development of atherosclerosis between 8 and 14 weeks. Progression of the disease was accompanied by an accumulation of macrophages and increased expression of IL17 and IFN‐γ in the aorta. Hypercholesterolemia resulted in increased immune response to modified lipids and aortic inflammation, with an expansion of Th17 cells in the spleen. Progression of atherosclerosis showed a positive correlation (r = 0.84, P < 0.001) with Th17 cells and a negative correlation with Treg cells (r = 0.83, P < 0.001). IgM antibodies to Ox‐LDL and Th17 cells in spleen showed greatest association with disease development. Our results suggest that anti Ox‐LDL IgM antibodies, Th17 cells could be developed as a potential marker to study disease progression and to study the effect of therapeutic regulation of inflammation.
Degeneration of internal Kelvin waves in a continuous two-layer stratification
Authors: Ulloa Hugo N. , Winters Kraig B. , de la Fuente Alberto , Niño Yarko 
Published: July 2015

We explore the evolution of the gravest internal Kelvin wave in a two-layer rotating cylindrical basin, using direct numerical simulations (DNS) with a hyper-viscosity/diffusion approach to illustrate different dynamic and energetic regimes. The initial condition is derived from Csanady’s (J. Geophys. Res., vol. 72, 1967, pp. 4151–4162) conceptual model, which is adapted by allowing molecular diffusion to smooth the discontinuous idealized solution over a transition scale, ${\it\delta}_{i}$, taken to be small compared to both layer thicknesses $h_{\ell },\ell =1,2$. The different regimes are obtained by varying the initial wave amplitude, ${\it\eta}_{0}$, for the same stratification and rotation. Increasing ${\it\eta}_{0}$ increases both the tendency for wave steepening and the shear in the vicinity of the density interface. We present results across several regimes: from the damped, linear–laminar regime (DLR), for which ${\it\eta}_{0}\sim {\it\delta}_{i}$ and the Kelvin wave retains its linear character, to the nonlinear–turbulent transition regime (TR), for which the amplitude ${\it\eta}_{0}$ approaches the thickness of the (thinner) upper layer $h_{1}$, and nonlinearity and dispersion become significant, leading to hydrodynamic instabilities at the interface. In the TR, localized turbulent patches are produced by Kelvin wave breaking, i.e. shear and convective instabilities that occur at the front and tail of energetic waves within an internal Rossby radius of deformation from the boundary. The mixing and dissipation associated with the patches are characterized in terms of dimensionless turbulence intensity parameters that quantify the locally elevated dissipation rates of kinetic energy and buoyancy variance.
Theoretical Estimation of Maximum Ellipsoidal Magnitude of a Low-Viscosity Droplet in a Parallel Gas Stream
Authors: Wang Z.-B. , Bai H.-F. , Xia J.-X. , Zhong H.-Q. , Li Y.-C. 
Published: July 2015

ABSTRACTMaximum ellipsoidal magnitude of the droplet is an important basic parameter for calculating drag force, droplets axial-velocity and dispersed-phase pressure gradient in an annular-mist pipe flow. An analytical correlation to predict the maximum ellipsoidal magnitude of a low-viscosity droplet in a parallel gas stream based on energy conservation and volume conservation. Stagnant pressure distribution on droplet surface is revised from Flachsbart's formula. The proposed correlation has clear physical meaning and easy to use. The correlation captures the deformation mechanism with an average absolute percent error of 9.53%. The effect of stagnant pressure distribution on the proposed correlation's accuracy is discussed.
Simulations of Asymmetric Flow Structures around a Moving Sphere at Moderate Reynolds Number
Authors: Young D.-L. , Wu C.-S. , Wu C. , Lin Y.-C. 
Published: July 2015

ABSTRACTThe evolution of asymmetric leeward-side flow structures around a moving sphere in the viscous flow is investigated. Simulations are carried out to investigate the variations of vortex-ring system at the moderate Reynolds number. A parallel laboratory experiment is undertaken in this study. The sphere travels a certain distance at constant speed and then stops to collide with a wall. The motion of moving sphere in fluid is described by the hybrid Cartesian immersed boundary method. Drag forces behind the moving sphere are extremely substantial as the solid body falls through viscous fluid for comprehending the formation of wake flow. The dynamic behavior consists of growth and breakup of the vortices which depend on two specific moderate Reynolds numbers. The onset of physical instability in the wake is obviously affected at the Reynolds number of 800. The generated vortex-ring system rolls upward to compact the primary vortex ring and interact with the secondary vortex. An asymmetric generation of the pairs of vortices is developed since the physical instability effect leads to shed in the wake with the increasing Reynolds number. The results from numerical simulations are also conducted to exhibit good comparison with those from the laboratory experiment.
Investigations in Hydrostatic Planar Bearings Compensated by Tapered-Spool Restrictors II: Load Capacity and Static Stiffness
Authors: Kang Y. , Cheng H.-C. , Lee C.-W. , Hu S.-Y. 
Published: July 2015

ABSTRACTThis study including two parts investigates the influence of design parameters of tapered-spool restrictors and hydrostatic planar bearing on static characteristics of load capacity and static stiffness. The former part provides guides for the design of single-action and double-action tapered-spool restrictors. This part provides design guides for planar hydrostatic bearing and for matching up with tapered-spool restrictor. The equations of flow continuity are utilized to determine the film thickness for open-type planar bearing and worktable displacement for closed-type planar bearing with respect to the recess pressure, respectively. The load capacity can be obtained by multiplying recess pressure by effective area of bearing pad. Furthermore, the static stiffness can be obtained by differentiating the recess pressure with respect to film thickness or worktable displacement. The finding results give that the usage range of recess pressure, and the availability ranges of design parameters of restrictor and bearing parameters. Which are found for getting the maximum stiffness.
Magnetohydrodynamic Free Convective Flow of Nanofluids Past an Oscillating Porous Flat Plate in A Rotating System with Thermal Radiation and Hall Effects
Authors: Das S. , Jana R.N. , Makinde O.D. 
Published: July 2015

ABSTRACTThe unsteady magnetohydrodynamic free convective flow due to an oscillating porous flat plate in a rotating frame of reference are studied when thermal radiation and Hall currents are taken into consideration. The entire system rotates with a uniform angular velocity about an axis normal to the plate. A uniform magnetic field is applied along the normal to the plate directed into the fluid region. Copper, alumina and titania water nanofluids are considered. The governing equations are solved analytically by employing the small perturbation approximation. The numerical results for fluid velocity and temperature are presented graphically for the pertinent parameters and discussed in details.
Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies
Authors: Touvier Mathilde , Fassier Philippine , His Mathilde , Norat Teresa , Chan Doris S. M. , Blacher Jacques , Hercberg Serge , Galan Pilar , Druesne-Pecollo Nathalie , Latino-Martel Paule 
Published: July 2015

The objective of the present study was to conduct the first systematic review and meta-analysis of prospective studies investigating the associations between total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels and the risk of breast cancer. Relevant studies were identified in PubMed (up to January 2014). Inclusion criteria were original peer-reviewed publications with a prospective design. Random-effects models were used to estimate summary hazard ratios (HR) and 95 % CI. Distinction was made between studies that did or did not exclude cancer cases diagnosed during the first years of follow-up, thereby eliminating potential preclinical bias. Overall, the summary HR for the association between TC and breast cancer risk was 0·97 (95 % CI 0·94, 1·00; dose–response per 1 mmol/l increment, thirteen studies), and that between HDL-C and breast cancer risk was 0·86 (95 % CI 0·69, 1·09; dose–response per 1 mmol/l increment, six studies), with high heterogeneity (I2= 67 and 47 %, respectively). For studies that eliminated preclinical bias, an inverse association was observed between the risk of breast cancer and TC (dose–response HR 0·94 (95 % CI 0·89, 0·99), seven studies, I2= 78 %; highest v. lowest HR 0·82 (95 % CI 0·66, 1·02), nine studies, I2= 81 %) and HDL-C (dose–response HR 0·81 (95 % CI 0·65, 1·02), five studies, I2= 30 %; highest v. lowest HR 0·82 (95 % CI 0·69, 0·98), five studies, I2= 0 %). There was no association observed between LDL-C and the risk of breast cancer (four studies). The present meta-analysis confirms the evidence of a modest but statistically significant inverse association between TC and more specifically HDL-C and the risk of breast cancer, supported by mechanistic plausibility from experimental studies. Further large prospective studies that adequately control for preclinical bias are needed to confirm the results on the role of cholesterol level and its fractions in the aetiology of breast cancer.
Incidence of neoplasia in patients with unilateral epiphora
Authors: Bewes T , Sacks R , Sacks P L , Chin D , Mrad N , Wilcsek G , Tumuluri K , Harvey R 
Published: July 2015

AbstractBackground:Nasolacrimal duct obstruction is common and is usually a result of benign stricture formation. Although neoplasia near or around the lacrimal system may produce epiphora, the incidence of neoplasia from within the lacrimal system as a cause of nasolacrimal duct obstruction is not well documented.Methods:A retrospective study was performed on all patients undergoing dacryocystorhinostomy with a history of epiphora. The incidence of patients with operative findings of intra-lacrimal neoplasm was sought. Histopathologically confirmed cases were included.Results:The study comprised 537 patients, who underwent a total of 631 endoscopic dacryocystorhinostomy procedures between January 1998 and July 2013. Non-stenotic causes of nasolacrimal duct obstruction were encountered in 3.01 per cent of dacryocystorhinostomy procedures, and included neoplastic, inflammatory and infectious pathologies. Inverted papilloma was the most common cause, encountered in 0.79 per cent of dacryocystorhinostomy operations.Conclusion:These findings suggest that neoplasia is an uncommon but not a rare cause of nasolacrimal duct obstruction. Surgical teams performing high numbers of dacryocystorhinostomy procedures should be aware of such pathology and patients counselled appropriately.
Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study
Authors: Klump K. L. , Hildebrandt B. A. , O'Connor S. M. , Keel P. K. , Neale M. , Sisk C. L. , Boker S. , Burt S. A. 
Published: July 2015

BackgroundPrevious studies have shown significant within-person changes in binge eating and emotional eating across the menstrual cycle, with substantial increases in both phenotypes during post-ovulation. Increases in both estradiol and progesterone levels appear to account for these changes in phenotypic risk, possibly via increases in genetic effects. However, to date, no study has examined changes in genetic risk for binge phenotypes (or any other phenotype) across the menstrual cycle. The goal of the present study was to examine within-person changes in genetic risk for emotional eating scores across the menstrual cycle.MethodParticipants were 230 female twin pairs (460 twins) from the Michigan State University Twin Registry who completed daily measures of emotional eating for 45 consecutive days. Menstrual cycle phase was coded based on dates of menstrual bleeding and daily ovarian hormone levels.ResultsFindings revealed important shifts in genetic and environmental influences, where estimates of genetic influences were two times higher in post- as compared with pre-ovulation. Surprisingly, pre-ovulation was marked by a predominance of environmental influences, including shared environmental effects which have not been previously detected for binge eating phenotypes in adulthood.ConclusionsOur study was the first to examine within-person shifts in genetic and environmental influences on a behavioral phenotype across the menstrual cycle. Results highlight a potentially critical role for these shifts in risk for emotional eating across the menstrual cycle and underscore the need for additional, large-scale studies to identify the genetic and environmental factors contributing to menstrual cycle effects.