bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of internal herniation after gastric bypass surgery
Authors: Geubbels N , Lijftogt N , Fiocco M , van Leersum N J , Wouters M W J M , de Brauw L M 
Published: February 2015

AbstractBackgroundThe aim of this study was to provide a systematic and quantitative summary of the association between laparoscopic Roux-en-Y gastric bypass (LRYGB) and the reported incidence of internal herniation (IH). The route of the Roux limb and closure of mesenteric and/or mesocolonic defects are described as factors of influence.MethodsMEDLINE, Embase, the Cochrane Library and Web of Science were searched for relevant literature, references and citations according to the PRISMA statement. Two independent reviewers selected studies that evaluated incidence of IH after LRYGB and possible techniques for prevention. Data were pooled by route of the Roux limb and closure/non-closure of the mesenteric and/or mesocolonic defects.ResultsForty-five articles included data on 31 320 patients. Lowest IH incidence was in the antecolic group, with closure of all defects (1 per cent; P &lt; 0·001), followed by the antecolic group, with all defects left open and the retrocolic group with closure of the mesenteric and mesocolonic defect (both 2 per cent; P &lt; 0·001). The incidence of IH was highest in the antecolic group, with closure of the jejunal defect, and in the retrocolic group, with closure of all defects (both 3 per cent).ConclusionThe present systematic review includes a random-effects meta-analysis. The antecolic procedure, with closure of both the mesenteric and Petersen defects, has the lowest internal herniation incidence following laparoscopic Roux-en-Y gastric bypass.
Comprehensive Geriatric Assessment and predicted 3-year survival in treatment planning for frail patients with early breast cancer
Authors: Stotter A , Reed M W , Gray L J , Moore N , Robinson T G 
Published: February 2015

AbstractBackgroundEndocrine therapy alone has been a popular treatment for oestrogen receptor-positive breast cancer in elderly patients, although it may be inadequate in those surviving more than 2–3 years. The aim of this study was to estimate 3-year survival in frail patients with early breast cancer, to inform treatment decisions.MethodsA risk score was created to estimate 3-year survival in individual patients using data from patients who had Comprehensive Geriatric Assessment (CGA) in a specialist clinic before decisions about their breast cancer treatment were made. The data were analysed using logistic regression.ResultsNinety-seven (29·6 per cent) of the 328 patients had died by 3 years. Four components of the assessment proved strongly associated with survival: Mini Mental State Examination, Barthel Index of Activities of Daily Living, instrumental Activities of Daily Living and American Association of Anesthesiologists fitness grade. The derived CGA risk score gave an adequate level of discrimination and calibration, with an area under the receiver operating characteristic (ROC) curve of 0·75 (95 per cent c.i. 0·67 to 0·82) (Hosmer–Lemeshow statistic χ2 = 7·9, P = 0·448).ConclusionDetailed assessment can allow prediction of survival probability in frail elderly patients. Good scores indicate good survival prospects and a likely benefit from surgery; poor scores are associated with reduced survival, although with wide variation. CGA is recommended before making decisions on best treatment.
Two‐year results of a low‐dose drug‐coated balloon for revascularization of the femoropopliteal artery: Outcomes from the ILLUMENATE first‐in‐human study
Authors: Schroeder Henrik , Meyer Dirk‐Roelfs , Lux Beata , Ruecker Ferdinand , Martorana Marcello , Duda Stephan 
Published: February 2015

ObjectivesTo assess the safety and effectiveness of the Stellarex™ drug‐coated angioplasty balloon (DCB) to inhibit restenosis in the superficial femoral and/or popliteal artery.BackgroundTreatment of peripheral arterial disease is challenged by restenosis, requiring revascularization procedures to maintain patency. DCBs are designed to deliver an anti‐proliferative drug to the vessel wall to diminish smooth muscle cell proliferation and maintain patency.MethodsThis prospective, single‐arm, multicenter study enrolled 50 patients with 58 lesions in the first cohort that required pre‐dilatation with an uncoated angioplasty balloon prior to inflation of the DCB. The primary effectiveness endpoint was 6‐month late lumen loss (LLL). The major secondary endpoint was major adverse event (MAE) rate at 6 months, defined as cardiovascular death, amputation, and/or ischemia‐driven target lesion revascularization.ResultsThe mean lesion length was 7.2 cm and baseline stenosis was 75.1%. Calcification was present in 62.1% of lesions and 12.1% were occluded. Both endpoints met their prespecified performance goals; at 6 months, the MAE rate was 4% and the mean LLL was 0.54 mm. The primary patency rate was 89.5% at 12 months and 80.3% at 24 months. The freedom from clinically‐driven target lesion revascularization rate, per Kaplan‐Meier estimate, was 90.0% at 12 months and 85.8% at 24 months. Additionally, there were no amputations or cardiovascular deaths reported through 24 months.ConclusionsThe Stellarex DCB provides safe and durable clinical outcomes for treatment of femoropopliteal artery disease through 24 months. © 2015 Wiley Periodicals, Inc.
XAS and XES Techniques Shed Light on the Dark Side of Ziegler–Natta Catalysts: Active‐Site Generation
Authors: Groppo Elena , Gallo Erik , Seenivasan Kalaivani , Lomachenko Kirill A. , Sommazzi Anna , Bordiga Silvia , Glatzel Pieter , van Silfhout Roelof , Kachatkou Anton , Bras Wim , Lamberti Carlo 
Published: February 2015

AbstractThe local structure and the electronic properties of the active Ti sites in heterogeneous Ziegler–Natta catalysts, generated in situ by interaction of the precatalyst with different Al‐alkyl activators, were investigated by combining X‐ray absorption and valence‐to‐core X‐ray emission spectroscopy (XAS and vtc‐XES), coupled with UV/Vis, FTIR, and DFT theoretical calculations. Irrespective of the activator used, the active system was found to be a highly dispersed TiCl3‐like phase in which the Ti sites are surrounded, not only by bridged chlorine ligands (with the same bond length of bulk TiCl3), but also by terminal chlorine ligands, at a much shorter distance. These results set Ziegler–Natta catalysts in the category of complex nanomaterials. Despite the observation that the investigated catalysts polymerize ethylene, cutting‐edge XAS and XES techniques do not yet offer unequivocal proof for the presence of any alkyl chain attached to the Ti sites, as a consequence of the small fraction of the active sites.
Copper‐Mediated Aromatic Radiofluorination Revisited: Efficient Production of PET Tracers on a Preparative Scale
Authors: Zlatopolskiy Boris D. , Zischler Johannes , Krapf Philipp , Zarrad Fadi , Urusova Elizaveta A. , Kordys Elena , Endepols Heike , Neumaier Bernd 
Published: February 2015

AbstractTwo novel methods for copper‐mediated aromatic nucleophilic radiofluorination were recently reported. Evaluation of these methods reveals that, although both are efficient in small‐scale experiments, they are inoperative for the production of positron emission tomography (PET) tracers. Since high base content turned out to be responsible for low radiochemical conversions, a “low base” protocol has been developed which affords 18F‐labeled arenes from diaryliodonium salts and aryl pinacol boronates in reasonable yields. Furthermore, implementation of our “minimalist” approach to the copper‐mediated [18F]‐fluorination of (mesityl)(aryl)iodonium salts allows the preparation of 18F‐labeled arenes in excellent RCCs. The novel radiofluorination method circumvents time‐consuming azeotropic drying and avoids the utilization of base and other additives, such as cryptands. Furthermore, this procedure enables the production of clinically relevant PET tracers; [18F]FDA, 4‐[18F]FPhe, and [18F]DAA1106 are obtained in good isolated radiochemical yields. Additionally, [18F]DAA1106 has been evaluated in a rat stroke model and demonstrates excellent potential for visualization of translocator protein 18 kDa overexpression associated with neuroinflammation after ischemic stroke.
ChemInform Abstract: Chemical Modification and Energetically Favorable Atomic Disorder of a Layered Thermoelectric Material TmCuTe2 Leading to High Performance.
Authors: Lin Hua , Chen Hong , Shen Jin‐Ni , Chen Ling , Wu Li‐Ming 
Published: February 2015

AbstractTmCuTe2 is prepared by heating stoichiometric amounts of the elements (SiO2 crucible in evacuated quartz tube, 723 K, 1 d, 2.
ChemInform Abstract: Rational Design of Lower‐Temperature Solid Oxide Fuel Cell Cathodes via Nanotailoring of Co‐Assembled Composite Structures.
Authors: Lee Kang Taek , Lidie Ashley A. , Yoon Hee Sung , Wachsman Eric D. 
Published: February 2015

AbstractThe nanocomposite La0.8Sr0.2MnO3/Bi1.6 Er0.4O3 cathode is obtained by an in situ co‐assembly process through uniquely conjugated reverse‐strike coprecipitation and glycine‐nitrate combustion at extremely low temperature (<300 °C).
ChemInform Abstract: Copper Incorporated CuxMo6S8 (x ≥ 1) Chevrel‐Phase Cathode Materials Synthesized by Chemical Intercalation Process for Rechargeable Magnesium Batteries.
Authors: Woo Sang‐Gil , Yoo Jong‐Yeol , Cho Woosuk , Park Min‐Sik , Kim Ki Jae , Kim Jae‐Hun , Kim Jeom‐Soo , Kim Young‐Jun 
Published: February 2015

AbstractThe title Chevrel phases with x up to x = 1.7 as cathode materials for rechargeable Mg batteries are synthesized by chemical intercalation from stoichiometric mixtures of Mo6S8 powder and Cu metal (80 °C, 36 h).
ChemInform Abstract: Two New Four‐Connected Zeolite‐Like Magnesium Aluminophosphates with Intersecting 8‐Ring Channels.
Authors: Wang Y. Y. , Mu Y. , Sun Y. J. , Li J. Y. 
Published: February 2015

AbstractTwo new Mg‐containing aluminophosphates, (H2pip) [Mg2Al6(PO4)8 (H2O)4] (pip: piperazine) are hydrothermally obtained from gels of overall molar compositions of 1.0Al2O3:0.67MgO:2.91P2O5 :1.7pip:224H2O (I) or 1.0Al2O3:0.67MgO:2.62P2O5 :2.63pip:224H2O (II) differing slightly in the H3PO4 and piperazine amounts (autoclave, 180 °C, 3 d).
ChemInform Abstract: Asymmetric Benzoylation and Henry Reaction Using Reusable Polytopic Bis(oxazoline) Ligands and Copper(II).
Authors: Torres‐Werle Maria , Nano Adela , Maisse‐Francois Aline , Bellemin‐Laponnaz Stephane 
Published: February 2015

AbstractThe method for the asymmetric benzoylation of meso‐hydrobenzoin (I) can also be used for the resolution of rac‐hydrobenzoin using similar conditions.
ChemInform Abstract: Regioselective Ring‐Opening Nucleophilic Addition of Aziridines Through Photoredox Catalyst.
Authors: Sun Hongnan , Yang Chao , Lin Run , Xia Wujiong 
Published: February 2015

AbstractVisible light induced regioselective ring‐opening of aziridines by nucleophiles provides a convenient access to various 1,2‐bifunctional compounds.
ChemInform Abstract: Syntheses of Acridines and Quinazoline‐2,4(1H,3H)‐dithiones by Rearrangements of N‐Heterocyclic Carbenes of Indazole.
Authors: Schmidt Andreas , Guan Zong , Gjikaj Mimoza 
Published: February 2015

AbstractN‐Heterocyclic carbenes generated by deprotonation of imidazolium salts (III) with K3PO4 or K2CO3 suffer a rearrangement to acidines in refluxing organic solvents.
ChemInform Abstract: Selective Difluoroalkylation of Alkenes by Using Visible Light Photoredox Catalysis.
Authors: Yu Chunghyeon , Iqbal Naeem , Park Sehyun , Cho Eun Jin 
Published: February 2015

AbstractThe chemoselectivity of the title mild reaction is controlled by the choice of the base producing difluoroalkylated alkanes and alkenes.
ChemInform Abstract: Exploiting the Nucleophilicity of N—H Imines: Synthesis of Enamides from Alkyl Azides and Acid Anhydrides.
Authors: Han Junghoon , Jeon Mina , Pak Han Kyu , Rhee Young Ho , Park Jaiwook 
Published: February 2015

AbstractPhotolysis of azides in the presence of a dimeric Ru‐complex catalyst gives N‐H intermediates, which upon subsequent acylation and isomerization furnish a wide variety of enamide derivatives.
ChemInform Abstract: General and Selective Reductive Amination of Carbonyl Compounds Using a Core—Shell Structured Co3O4/NGr@C Catalyst.
Authors: Stemmler Tobias , Westerhaus Felix A. , Surkus Annette‐Enrica , Pohl Marga‐Martina , Junge Kathrin , Beller Matthias 
Published: February 2015

AbstractThe cheap heterogeneous catalyst, core‐shell structured Co3O4 nanocomposite encapsulated with N‐doped graphene, allows an efficient domino reductive amination of carbonyl compounds with nitroarenes.
ChemInform Abstract: A Highly Efficient, Ligand‐Free and Recyclable SBA‐15 Supported Cu2O Catalyzed Cyanation of Aryl Iodides with Potassium Hexacyanoferrate(II).
Authors: Yin Wenzhu , Liu Rui , He Guangke , Lv Wangjie , Zhu Hongjun 
Published: February 2015

AbstractThe highly selective supported Cu2O catalyst exhibits wide functional group tolerance.
ChemInform Abstract: Visible Light‐Induced γ‐Alkoxynitrile Synthesis via Three‐Component Alkoxycyanomethylation of Alkenes.
Authors: Yi Hong , Zhang Xu , Qin Chu , Liao Zhixiong , Liu Jie , Lei Aiwen 
Published: February 2015

AbstractThe photolytic three‐component alkoxycyanomethylation of alkenes, bromoacetonitril, and alcohols in the presence of an Ir‐photoredox catalyst is developed.
ChemInform Abstract: HBF4·OEt2: An Efficient Fluorinated Acid Catalyst for the One‐Pot Synthesis of Secondary and Tertiary N‐Homoallylic Carbamates.
Authors: Baishya Gakul , Hazarika Nabajyoti , Sarmah Barnali 
Published: February 2015

AbstractThe advantages of the new method, compared with existing procedures, are reduced reaction times, higher yields, mild reaction conditions, easy scalability and use of readily available catalyst.
ChemInform Abstract: Synthesis of Conjugated Dienes and Polyenes via Diethyl Phosphite Promoted Carbonyl Olefination.
Authors: Wang Ru , Zhang Songlin 
Published: February 2015

AbstractThe products (II), (V), and (VII) are obtained as mixtures of their E/Z‐isomers, the ratio of which can only be determined for 2‐tolyl substituted α,β‐unsaturated derivatives.
ChemInform Abstract: Oxidative Cyclization Reaction of 2‐Aryl‐Substituted Cinnamates to Form Phenanthrene Carboxylates by Using MoCl5.
Authors: Wehming Kathrin , Schubert Moritz , Schnakenburg Gregor , Waldvogel Siegfried R. 
Published: February 2015

AbstractThe reagent mixture MoCl5/TiCl4 is successfully applied for the oxidative cyclization of α‐aryl substituted cinnamates to the corresponding phenanthrenes.
ChemInform Abstract: Efficient Construction of Highly Functionalized endo′‐Selective Spiro[pyrrolidin‐2,3′‐oxindoles] via a Regioselective 1,3‐Dipolar Cycloaddition Reaction Between 3‐Amino Oxindoles as Azomethine Ylide Precursors and Nitroalkenes.
Authors: Sun Hongbao , Wang Xiaoyan , Chen Yi , Ouyang Liang , Liu Jie , Zhang Yiwen 
Published: February 2015

AbstractAzomethine ylides, generated in situ from oxindoles and aldehydes undergo 1,3‐dipolar cycloaddition with nitroalkanes.
ChemInform Abstract: Consecutive Oxygen‐Based Oxidations Convert Amines to α‐Cyanoepoxides.
Authors: Ushakov Dmitry B. , Gilmore Kerry , Seeberger Peter H. 
Published: February 2015

AbstractThe photooxidation of amines in a continuous‐flow reactor followed by treatment of intermediate imines with methyl cyanoacetate or malononitrile leads to desired α‐cyanoepoxides such as (III) and (V).
ChemInform Abstract: N‐Chlorophthalimide as a Mild and Efficient Chlorination Reagent in the Gassman ortho Alkylation of Aromatic Amines. Synthesis of 3‐(Methylthio)oxindoles.
Authors: Cybulski Marcin , Formela Adam , Fokt Izabela 
Published: February 2015

AbstractThe modified mild conditions for Gassman ortho alkylation of aromatic amines allow the isolation of the intermediate α‐amidosulfides (III), which are cyclized to produce 3‐(methylthio)oxindoles.
ChemInform Abstract: I2‐Mediated C3‐Formylation of Indoles by Tertiary Amine and H2O.
Authors: Zhang Bo , Liu Bin , Chen Jianbin , Wang Jiehui , Liu Miaochang 
Published: February 2015

AbstractUsing TMEDA as carbonyl source, I2/Na2CO3‐promoted formylation of N‐alkylated as well as free indoles gives 3‐formylated indoles regioselectively under tolerance of a broad spectrum of functional groups.
ChemInform Abstract: One‐Pot Regioselective Synthesis of Novel Oximino Ester‐Containing 1‐Aryl‐4‐chloro‐3‐oxypyrazoles as Potential Fungicides.
Authors: Li Yi , Liu Yuan‐Yuan , Chen Nan‐Qing , Lue Kun‐Zhi , Xiong Xiao‐Hui , Li Jie 
Published: February 2015

AbstractNew compounds (III) are tested for their fungicidal activities against Sclerotinia sclerotiorum and Gibberella zeae.
ChemInform Abstract: Chromeno[2,3‐c]pyrroles by One‐Pot Multicomponent Domino Addition—Amination Reaction.
Authors: Terzidis Michael A. , Tsiaras Vassilios G. , Drosos Nicolaos M. , Kasapidou Paraskevi M. , Stephanidou‐Stephanatou Julia , Tsoleridis Constantinos A. , Buth Gernot , Kostakis George E. 
Published: February 2015

AbstractThe use of diisopropyl azodicarboxylate instead of the diethyl ester (II) results in lower yields.
ChemInform Abstract: Regiospecific Synthesis of 1‐Trifluoromethylisoquinolines Enabled by Photoredox Somophilic Vinyl Isocyanide Insertion.
Authors: Cheng Yuanzheng , Yuan Xiangai , Jiang Heng , Wang Ruzhi , Ma Jing , Zhang Yan , Yu Shouyun 
Published: February 2015

AbstractThe title reaction is achieved from isocyanides of type (I), (IV), and (VII) with Umemoto′s reagent (II) in the presence of an Ir‐catalyst.
ChemInform Abstract: One‐Pot Synthesis of Novel Pyrido[2,3‐d]pyrimidines Using HAp‐Encapsulated‐γ‐Fe2O3 Supported Sulfonic Acid Nanocatalyst under Solvent‐Free Conditions.
Authors: Mohsenimehr Moona , Mamaghani Manouchehr , Shirini Farhad , Sheykhan Mehdi , Moghaddam Fatemeh Azimian 
Published: February 2015

AbstractOptimum reaction conditions are examined for the three‐component one‐pot reaction of pyrimidine (I), aromatic aldehydes (II), and Meldrum′s acid (III) to afford title compounds (IV).
ChemInform Abstract: Dehydrogenative N‐Incorporation: A Direct Approach to Quinoxaline N‐Oxides under Mild Conditions.
Authors: Chen Feng , Huang Xiaoqiang , Li Xinyao , Shen Tao , Zou Miancheng , Jiao Ning 
Published: February 2015

AbstractA one‐pot method starting from anisidine (XI) and acetophenone (XII) is also demonstrated.
ChemInform Abstract: Synthesis of N‐Alkyl‐N′‐aryl‐piperazines via Copper‐Catalyzed C—N Bond Formation.
Authors: Yavari Issa , Bayat Mohammad J. , Ghazanfarpour‐Darjani Majid 
Published: February 2015

AbstractSequential CuI‐catalyzed alkylation/arylation of DABCO gives the title compounds in yields between 70‐80%.
ChemInform Abstract: Synthesis of Trifluoromethylated [1,4]Diazepines from 1,1,1‐Trifluoroalk‐3‐yn‐2‐ones.
Authors: Romanov Alexey R. , Rulev Alexander Yu. , Ushakov Igor A. , Muzalevskiy Vasiliy M. , Nenajdenko Valentine G. 
Published: February 2015

AbstractThe target heterocycles are formed under mild conditions in good yields and with high selectivity.
ChemInform Abstract: Bioinspired Total Synthesis of Gymnothelignan N.
Authors: Li Huilin , Zhang Yuanyuan , Xie Xingang , Ma Haichen , Zhao Changgui , Zhao Gaoyuan , She Xuegong 
Published: February 2015

AbstractThe total synthesis of the title compound (I) is accomplished in 13 steps and 6.7% overall yield via syn Evans aldol reaction, an intramolecular hydrogenative dehydration reaction, and a phenol oxidative dearomatization/Friedel‐crafts reaction.
ChemInform Abstract: Biomineralization‐Inspired Synthesis of Functional Organic/Inorganic Hybrid Materials: Organic Molecular Control of Self‐Organization of Hybrids
Authors: Arakaki Atsushi , Shimizu Katsuhiko , Oda Mayumi , Sakamoto Takeshi , Nishimura Tatsuya , Kato Takashi 
Published: February 2015

AbstractReview: 140 refs.
Kontinuierliche Reaktionsführung der selektiven Hydrierung von Benzol zu Cyclohexen in einem Vier‐Phasensystem
Authors: Spod Hendrik , Lucas Martin , Claus Peter 
Published: February 2015

AbstractDie Produktion von Nylon 6 und Nylon 6.6 basiert derzeit auf der vollständigen Hydrierung von Benzol zu Cyclohexan an Nickel‐ oder Platinkatalysatoren und dessen anschließender Oxidation bei sehr geringen Umsätzen zu einem Cyclohexanol/Cyclohexanon‐Produktgemisch. Dieses wird weiter zu ϵ‐Caprolactam oder Adipinsäure umgesetzt. Eine alternative Reaktionsroute ist die selektive Hydrierung von Benzol zu Cyclohexen und der anschließenden Hydratisierung an sauren Katalysatoren zu Cyclohexanol. Ein Laborverfahren zur selektiven Benzolhydrierung unter Verwendung eines Gas/Flüssig/Flüssig/Fest(G/L/L/S)‐Systems in einem kontinuierlich betriebenen Rührkessel (CSTR) wird vorgestellt.
Left Ventricular Diastolic Dysfunction and E/E′ Ratio as the Strongest Echocardiographic Predictors of Reduced Exercise Capacity After Acute Myocardial Infarction
Authors: Fontes‐Carvalho Ricardo , Sampaio Francisco , Teixeira Madalena , Rocha‐Gonçalves Francisco , Gama Vasco , Azevedo Ana , Leite‐Moreira Adelino 
Published: February 2015

AbstractBackgroundThe mechanisms that determine reduced exercise capacity after acute myocardial infarction (AMI) are not fully understood, especially the relative role of left ventricular diastolic and systolic function.HypothesisTo evaluate the role of different diastolic and systolic function echocardiographic parameters as predictors of reduced functional capacity in patients after AMI.MethodsOne month after AMI, 225 patients (84% male; mean age, 55.1 ± 10.9 years) were enrolled and underwent detailed echocardiography and cardiopulmonary exercise test on the same day. Systolic and diastolic function was evaluated by echocardiography according to the latest consensus recommendations, including tissue Doppler evaluation. Exercise capacity was evaluated with peak oxygen consumption (VO2).ResultsPeak VO2 was significantly correlated with early diastolic tissue Doppler velocity (E′) septal (r = 0.42, P < 0.001), E′ lateral (r = 0.35, P < 0.001), septal E/E′ ratio (r = −0.35, P = 0.001), and lateral E/E′ (r = −0.27, P < 0.001). These diastolic function parameters predicted impaired exercise capacity (VO2 <19 mL/kg/min), with an area under the receiver operating characteristic curve of 0.77 (95% confidence interval [CI]: 0.68–0.86, P < 0.001) for septal E/E′. On multivariate analysis, for each unit increase in septal E/E′ ratio there was a −0.35 (95% CI: −0.54 to −0.15) mL/kg/min decrease in peak VO2 independently of age, sex, body mass index, hypertension, and diabetes. There was a mild correlation between peak VO2 and systolic function parameters (r = 0.17, P = 0.01 with ejection fraction; and r = 0.23, P = 0.02 with lateral systolic tissue Doppler velocity) that persisted after multivariate adjustment.ConclusionsAfter AMI, resting diastolic function parameters were the strongest correlates of exercise tolerance. Septal E/E′ ratio was the best echocardiographic predictor of reduced functional capacity.