bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attenuated serotonin transporter association between dorsal raphe and ventral striatum in major depression
Authors: Hahn Andreas , Haeusler Daniela , Kraus Christoph , Höflich Anna S. , Kranz Georg S. , Baldinger Pia , Savli Markus , Mitterhauser Markus , Wadsak Wolfgang , Karanikas Georgios , Kasper Siegfried , Lanzenberger Rupert 
Published: January 2014

AbstractSuffering from anhedonia, patients with major depressive disorder (MDD) exhibit alterations in several parts of the serotonergic neurotransmitter system, which are in turn involved in reward processing. However, previous investigations of the serotonin transporter (SERT) focused on regional differences with varying results depending on the clinical syndrome. Here, we aimed to describe the serotonergic system of MDD patients on a network level by evaluating SERT associations across brain regions. Twenty medication free patients with major depression and 20 healthy controls underwent positron emission tomography using the radioligand [11C]DASB. SERT binding potentials (BPND) were quantified voxel‐wise with the multilinear reference tissue model 2. In addition, SERT BPND was extracted from the dorsal raphe nucleus (DRN) as an indicator of midbrain serotonergic neurotransmission. Whole‐brain linear regression analysis was applied to evaluate the association of DRN SERT bindings to those in projection areas, which was followed by ANCOVA to assess differences in interregional relationships between patients and controls. Although both groups showed widespread positive correlations, group differences were restricted to decreased SERT associations between the DRN and the ventral striatum (right and left respectively: t = 5.85, P < 0.05 corrected and t = 5.07, P < 0.1 corrected) when comparing MDD patients (R2 = 0.11 and 0.24) to healthy subjects (R2 = 0.72 and 0.66, P < 0.01 and 0.05 corrected). Adjusting for age and sex did not change these findings. This study indicates a disturbed regulation between key regions involved in reward processing via the SERT. Our interregional approach highlights the importance of evaluating pathophysiological alterations on a network level to gain complementary information in addition to regional investigations. Hum Brain Mapp 35:3857–3866, 2014. © 2014 Wiley Periodicals, Inc.
Intensity and sulci landmark combined brain atlas construction for Chinese pediatric population
Authors: Luo Yishan , Shi Lin , Weng Jian , He Hongjian , Chu Winnie C.W. , Chen Feiyan , Wang Defeng 
Published: January 2014

AbstractConstructing an atlas from a population of brain images is of vital importance to medical image analysis. Especially in neuroscience study, creating a brain atlas is useful for intra‐ and inter‐population comparison. Research on brain atlas construction has attracted great attention in recent years, but the research on pediatric population is still limited, mainly due to the limited availability and the relatively low quality of pediatric magnetic resonance brain images. This article is targeted at creating a high quality representative brain atlas for Chinese pediatric population. To achieve this goal, we have designed a set of preprocessing procedures to improve the image quality and developed an intensity and sulci landmark combined groupwise registration method to align the population of images for atlas construction. As demonstrated in experiments, the newly constructed atlas can better represent the size and shape of brains of Chinese pediatric population, and show better performance in Chinese pediatric brain image analysis compared with other standard atlases. Hum Brain Mapp 35:3880–3892, 2014. © 2014 Wiley Periodicals, Inc.
How to Improve E‐Satisfaction and E‐Loyalty and Strengthen the Links Between Them: Value From Regulatory Fit
Authors: Wu Cou‐Chen , Hsu Chia‐Lin 
Published: January 2014

AbstractThis article aims to investigate how regulatory fit can improve e‐satisfaction and e‐loyalty and strengthen the links between e‐satisfaction and both its antecedents (two technology acceptance model factors and the perceived quality of e‐shopping) and consequence (e‐loyalty). The research model and hypotheses are constructed through a literature review. An empirical study is performed to test the proposed research model, using survey research. The data are gathered via a questionnaire, which is developed on the basis of prior empirical studies. Results from this study point to the following: first, the two technology acceptance model factors and the perceived quality of e‐shopping significantly affect e‐satisfaction, which in turn e‐loyalty. Second, regulatory fit not only improves e‐satisfaction and e‐loyalty but also strengthens the links between e‐satisfaction and both its antecedents and consequence. On the basis of these findings, the implications are discussed and directions for future research are highlighted.
Palladium‐ and Solvent‐Free Synthesis of Ynones by Copper(I)‐Catalyzed Acylation of Terminal Alkynes with Acyl Chlorides under Aerobic Conditions
Authors: Mohammadi Elmira , Movassagh Barahman , Navidi Mozhgan 
Published: January 2014

AbstractAir‐stable CuI/cryptand‐22 complex was found to be a highly active catalyst for the solvent‐free cross‐coupling reaction of terminal alkynes with different acyl chlorides in the presence of Et3N as base to give the corresponding ynones in quantitative yields.
Insights into the Synthesis of Steroidal A‐Ring Olefins
Authors: Varela Carla L. , Roleira Fernanda M. F. , Costa Saul C. P. , Pinto Alexandra S. C. T. , Martins Ana I. O. S. , Carvalho Rui A. , Teixeira Natércia A. , Correia‐da‐Silva Georgina , Tavares‐da‐Silva Elisiário 
Published: January 2014

AbstractThe classical synthesis, followed by purification of the steroidal A‐ring Δ1‐olefin, 5α‐androst‐1‐en‐17‐one (5), from the Δ1‐3‐keto enone, (5α,17β)‐3‐oxo‐5‐androst‐1‐en‐17‐yl acetate (1), through a strategy involving the reaction of Δ1‐3‐hydroxy allylic alcohol, 3β‐hydroxy‐5α‐androst‐1‐en‐17β‐yl acetate (2), with SOCl2, was revisited in order to prepare and biologically evaluate 5 as aromatase inhibitor for breast cancer treatment. Surprisingly, the followed strategy also afforded the isomeric Δ2‐olefin 6 as a by‐product, which could only be detected on the basis of NMR analysis. Optimization of the purification and detection procedures allowed us to reach 96% purity required for biological assays of compound 5. The same synthetic strategy was applied, using the Δ4‐3‐keto enone, 3‐oxoandrost‐4‐en‐17β‐yl acetate (8), as starting material, to prepare the potent aromatase inhibitor Δ4‐olefin, androst‐4‐en‐17‐one (15). Unexpectedly, a different aromatase inhibitor, the Δ3,5‐diene, androst‐3,5‐dien‐17‐one (12), was formed. To overcome this drawback, another strategy was developed for the preparation of 15 from 8. The data now presented show the unequal reactivity of the two steroidal A‐ring Δ1‐ and Δ4‐3‐hydroxy allylic alcohol intermediates, 3β‐hydroxy‐5α‐androst‐1‐en‐17β‐yl acetate (2) and 3β‐hydroxyandrost‐4‐en‐17β‐yl acetate (9), towards SOCl2, and provides a new strategy for the preparation of the aromatase inhibitor 12. Additionally, a new pathway to prepare compound 15 was achieved, which avoids the formation of undesirable by‐products.
Three New Chromanones from Calea clausseniana
Authors: do Nascimento Andréa M. , de Oliveira Dionéia C. R. 
Published: January 2014

AbstractThree new chromanones, uniflorol A acetate (1), uniflorol B acetate (2), and 2,2‐dimethyl‐6‐{1‐[(4′‐acetoxy)angeloyloxy]ethyl}chroman‐4‐one (3), together with the known chromanone 4, and two known p‐hydroxyacetophenone derivatives, 5 and 6, were isolated from the CH2Cl2 crude extract of the underground parts of Calea clausseniana Baker. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.
Irigermanone, a Noriridal with Unprecedented Methylketone Function, from Iris germanica
Authors: Potterat Olivier , Herzog Carmela , Raith Melanie , Ebrahimi Samad Nejad , Hamburger Matthias 
Published: January 2014

AbstractA new iridal, irigermanone (1) and nine known congeners, 2–10, respectively, have been isolated from the dried rhizomes of German iris (Iris germanica). The structure of 1 was established by spectroscopic methods including HR‐ESI‐MS, 1D‐ and 2D‐NMR, and electronic circular dichroism (ECD) spectroscopy. Compound 1 is a structurally unique noriridal, and it possesses an unprecedented methylcarbonyl group instead of the α,β‐unsaturated aldehyde function typical for this group of triterpenes.
Global nonlinear and nonstationary climate change effects on regional precipitation and forest phenology in Panama, Central America
Authors: Chang Ni‐Bin , Vasquez Miguel Valdez , Chen Chi‐Farn , Imen Sanaz , Mullon Lee 
Published: January 2014

AbstractThe inherent effects of global sea surface temperature (SST) anomalies on hydrological cycle and vegetation cover complicate the structure of tropical climate at the regional scale. Assessing hydrological processes related to climate forcing is important in Central America because it is surrounded by both the Pacific and Atlantic oceans and two continental landmasses. In this study, the use of high‐resolution remote sensing imagery in wavelet analysis helps identify nonstationary characteristics of hydrological and ecological responses. The wavelet‐based empirical orthogonal function (WEOF) further reflects the nonlinear relationship between the Atlantic and Pacific SST and the greenness of a pristine forested site in Panama, La Amistad International Park. Integrated WEOF and descriptive statistics for data analysis reveal a higher temporal variability in terrestrial precipitation relative to in situ land surface temperature and its probable effects on the presence of dry periods. Such teleconnection signals of SST were identified as a driving force of decline in tropical forest greenness during dry periods. The results of our remote sensing‐based wavelet analysis showed intra‐annual high‐frequency and biennial to triennial low‐frequency signals between enhanced vegetation index/precipitation datasets and SST indices in both Atlantic and Pacific oceans. A spatiotemporal priority search further confirmed the importance of the effects of the El Niño–Southern Oscillation (ENSO) over terrestrial responses in the selected study site. Coincidence of the effect of ENSO teleconnection patterns on precipitation and vegetation suggests possible impacts of El Niño‐associated droughts in Central America, accompanied by reduced rainfall, especially during the first months of rainy season (June, July, and August), and decline in vegetation cover during the dry season (March and April). Copyright © 2014 John Wiley & Sons, Ltd.
Human bone reactions around implants with adverse interfacial bone strain over 20 years
Authors: Traini Tonino , Mangano Carlo , Perrotti Vittoria , Caputi Sergio , Coelho Paulo , Piattelli Adriano , Iezzi Giovanna 
Published: January 2014

AbstractAimsIt has been accepted that bone damage and subsequent resorption occurs in cases of adverse interfacial bone strain. Fractured implants represents an important opportunity for evaluating the bone response to overstrain. The objective of the study was to analyze the bone morphology and morphometry around retrieved fractured implants in humans. Five fractured implants retrieved after 22.4 (± 2.8) years were used in the present study. The investigation was conducted in a transmitted brightfield and circularly polarized light Microscope. The parameters considered were the total bone area, total bone remodeling area, bone‐remodeling rate (BRR), and bone transverse collagen fibers orientation (CFO).FindingsFor grouped samples, the BRR was 51.9% (± 10) while the transverse CFO was 13.0% (± 9.7). The interthread BRR was 58.1% (± 4.0) for level 1 and 40.4% (± 12.8) for level 2 with a significant decrease in BRR (p = 0.019) as a function of depth along the implant length.ConclusionsBoth bone level and bone quality attains stability to a certain level with respect to implant neck fracture following physiologic interaction between mechanical and biological inputs. The BRR significantly decrease as function of threads depth. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1342–1352, 2014.
Biodegradable polymeric coatings on cochlear implant surfaces and their influence on spiral ganglion cell survival
Authors: Ceschi P. , Bohl A. , Sternberg K. , Neumeister A. , Senz V. , Schmitz K.P. , Kietzmann M. , Scheper V. , Lenarz T. , Stöver T. , Paasche G. 
Published: January 2014

AbstractTo improve the electrode–nerve interface of cochlear implants (CI), the role of poly(L‐lactide) (PLLA) and poly(4‐hydroxybutyrate) (P(4HB)) as potential coating matrices for CI was assessed both in vitro and in vivo in terms of degradation behavior and effects on spiral ganglion neurons, the main target of the electrical stimulation with a CI. Growth rates of fibroblasts on the polymers were investigated and a direct‐contact test with freshly isolated spiral ganglion cells (SGC) was performed. In addition, the effects of the polymer degradation inside the inner ear were evaluated in vivo. The polymer degradation was assessed by use of scanning electron microscopy in combination with an energy‐dispersive X‐ray analysis. In vitro, no influence of the polymers was detected on fibroblasts' viability and on SGC survival rate. In vivo, SGC density was decreased only 6 months after implantation in the basal and middle turns of the cochlea in comparison to normal‐hearing animals but not between implanted groups (coated or uncoated). The analysis of the electrode models showed that in vivo P(4HB) is characterized by a gradual degradation completed after 6 months; whereas, the PLLA coatings burst along their longitudinal axis but showed only little degradation within the same time frame. In conclusion, both polymers seem to justify further evaluation as possible coating for CI electrodes. Of the two options, due to its excellent coating adhesion/stability and optimal degradation behavior, P(4HB) may prove to be the more promising biodegradable polymer for designing a drug delivery system from the surface of CI electrodes. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1255–1267, 2014.
Efficacy of Salmonella typhimurium A1‐R Versus Chemotherapy on a Pancreatic Cancer Patient‐Derived Orthotopic Xenograft (PDOX)
Authors: Hiroshima Yukihiko , Zhao Ming , Maawy Ali , Zhang Yong , Katz Matthew H.G. , Fleming Jason B. , Uehara Fuminari , Miwa Shinji , Yano Shuya , Momiyama Masashi , Suetsugu Atsushi , Chishima Takashi , Tanaka Kuniya , Bouvet Michael , Endo Itaru , Hoffman Robert M. 
Published: January 2014

ABSTRACTThe aim of this study is to determine the efficacy of tumor‐targeting Salmonella typhimurium A1‐R (A1‐R) on pancreatic cancer patient‐derived orthotopic xenografts (PDOX). The PDOX model was originally established from a pancreatic cancer patient in SCID‐NOD mice. The pancreatic cancer PDOX was subsequently transplanted by surgical orthotopic implantation (SOI) in transgenic nude red fluorescent protein (RFP) mice in order that the PDOX stably acquired red fluorescent protein (RFP)‐expressing stroma for the purpose of imaging the tumor after passage to non‐transgenic nude mice in order to visualize tumor growth and drug efficacy. The nude mice with human pancreatic PDOX were treated with A1‐R or standard chemotherapy, including gemcitabine (GEM), which is first‐line therapy for pancreatic cancer, for comparison of efficacy. A1‐R treatment significantly reduced tumor weight, as well as tumor fluorescence area, compared to untreated control (P = 0.011), with comparable efficacy of GEM, CDDP, and 5‐FU. Histopathological response to treatment was defined according to Evans's criteria and A1‐R had increased efficacy compared to standard chemotherapy. The present report is the first to show that A1‐R is effective against a very low‐passage patient tumor, in this case, pancreatic cancer. The data of the present report suggest A1‐1 will have clinical activity in pancreatic cancer, a highly lethal and treatment‐resistant disease and may be most effectively used in combination with other agents. J. Cell. Biochem. 115: 1254–1261, 2014. © 2014 Wiley Periodicals, Inc.
SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response
Authors: Liu Diana J. , Hammer David , Komlos Daniel , Chen Kuang Yu , Firestein Bonnie L. , Liu Alice Y.‐C. 
Published: January 2014

AbstractNeurons have a limited capacity for heat shock protein (HSP) induction and are vulnerable to the pathogenic consequence of protein misfolding and aggregation as seen in age‐related neurodegenerative diseases. Sirtuin 1 (SIRT1), an NAD+‐dependent lysine deacetylase with important biological functions, has been shown to sustain the DNA‐binding state of HSF1 for HSP induction. Here we show that differentiation and maturation of embryonic cortical neurons and N2a neuroprogenitor cells is associated with decreases in SIRT1 expression and heat shock‐dependent induction of HSP70 protein. Tests of a pharmacological activator and an inhibitor of SIRT1 affirm the regulatory role of SIRT1 in HSP70 induction. Protein cross‐linking studies show that nuclear SIRT1 and HSF1 form a co‐migrating high molecular weight complex upon stress. The use of retroviral vectors to manipulate SIRT1 expression in N2a cells show that shRNA‐mediated knock down of SIRT1 causes spontaneous neurite outgrowth coincident with reduced growth rate and decreased induction of hsp70‐reporter gene, whereas SIRT1 over‐expression blocks the induced neural differentiation of N2a cells. Our results suggest that decreased SIRT1 expression is conducive to neuronal differentiation and this decrease contributes to the attenuated induction of HSPs in neurons. J. Cell. Physiol. 229: 1224–1235, 2014. © 2014 Wiley Periodicals, Inc.
Accelerating phase‐encoded proton MR spectroscopic imaging by compressed sensing
Authors: Cao Peng , Wu Ed X. 
Published: January 2014

PurposeTo develop a phase encoding reduction scheme based on compressed sensing (CS) for phase‐encoded 1H MR spectroscopic imaging (MRSI).Materials and MethodsPhantom and in vivo rat brain MRSI experiments were performed at 7 Tesla to examine the performance of CS approach and compare it with the full k‐space acquisition. The CS undersampling was performed by acquiring a pseudorandom and density‐varying subset of phase encodings. Residual water resonance was first removed from the undersampled k‐space dataset before CS reconstruction. The CS reconstruction was performed by a linearized Bregman iteration procedure for efficiency in computing large scale L1 minimization. The spectral and spatial fidelity was evaluated by comparing spectral linewidths and metabolite maps and voxel‐wise Bland‐Altman analysis.ResultsCS preserved the spectral resolution and metabolite content levels. No spectral broadening was observed, and the estimation biases of the metabolite content levels were no more than 4%. CS clearly preserved the boundaries of metabolite maps but led to slight loss of details in metabolite maps.ConclusionThis study demonstrated the feasibility of the proposed CS approach to accelerate phase‐encoded 1H MRSI. J. Magn. Reson. Imaging 2015;41:487–495.© 2013 Wiley Periodicals, Inc.
The Sky and Sustainable Tourism Development: A Case Study of a Dark Sky Reserve Implementation in Alqueva
Authors: Rodrigues Aurea L. O. , Rodrigues Apolónia , Peroff Deidre M. 
Published: January 2014

AbstractThis paper shows the development of a tourism product in a destination that uses the night sky as its main source of attraction. Using this innovative product has helped to create a distinctive image, which is likely to attract a more diverse range of visitors and has assisted in improving economic, social and environmental sustainability. First, we present an overview about sustainable tourism and the sky as a tourism resource followed by a case study, in Portugal, that illustrates the potential of Dark Sky activities for tourism development in rural regions. Copyright © 2014 John Wiley & Sons, Ltd.
Combining Ring‐Opening Metathesis Polymerization and Thiol‐Ene Coupling Chemistries: Facile Access to Novel Functional Linear and Nonlinear Macromolecules
Authors: Lowe Andrew B. , Liu Meina , van Hensbergen Johannes Arend , Burford Robert P. 
Published: January 2014

The aim of this article is to highlight recent examples in which two powerful synthetic tools, namely ring‐opening metathesis polymerization (ROMP) and thiol‐ene (including the thiol‐Michael variant) click chemistry have been combined to facilitate the preparation of novel functional materials of varying topology.
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Three‐dimensional brain MRI for DBS patients within ultra‐low radiofrequency power limits
Authors: Sarkar Subhendra N. , Papavassiliou Efstathios , Hackney David B. , Alsop David C. , Shih Ludy C. , Madhuranthakam Ananth J. , Busse Reed F. , La Ruche Susan , Bhadelia Rafeeque A. 
Published: January 2014

ABSTRACTBackgroundFor patients with deep brain stimulators (DBS), local absorbed radiofrequency (RF) power is unknown and is much higher than what the system estimates. We developed a comprehensive, high‐quality brain magnetic resonance imaging (MRI) protocol for DBS patients utilizing three‐dimensional (3D) magnetic resonance sequences at very low RF power.MethodsSix patients with DBS were imaged (10 sessions) using a transmit/receive head coil at 1.5 Tesla with modified 3D sequences within ultra‐low specific absorption rate (SAR) limits (0.1 W/kg) using T2, fast fluid‐attenuated inversion recovery (FLAIR) and T1‐weighted image contrast. Tissue signal and tissue contrast from the low‐SAR images were subjectively and objectively compared with routine clinical images of six age‐matched controls.ResultsLow‐SAR images of DBS patients demonstrated tissue contrast comparable to high‐SAR images and were of diagnostic quality except for slightly reduced signal.ConclusionsAlthough preliminary, we demonstrated diagnostic quality brain MRI with optimized, volumetric sequences in DBS patients within very conservative RF safety guidelines offering a greater safety margin. © 2014 International Parkinson and Movement Disorder Society
Evaluation of high resolution rainfall forecasts over Karnataka for the 2011 southwest and northeast monsoon seasons
Authors: Rakesh V. , Goswami P. , Prakash V. S. 
Published: January 2014

ABSTRACTEvaluation of real‐time rainfall forecast at the hobli (village cluster ∼10 km2) level from an atmospheric mesoscale model over Karnataka (located at southwest India, with nearly 56% of the workforce engaged in agricultural activities) for the southwest (June–September) and northeast (October–December) monsoon seasons of 2011 is presented in this study. The forecast system has been operationally implemented through data assimilation from a number of local observatories for effective applications as well as for proof of concept. A highlight of the study is the validation of the rainfall forecasts against observations at comparable resolution established by Karnataka State Natural Disaster Monitoring Centre, Government of Karnataka (KSNDMC). An evaluation of the forecast skill against daily observed rainfall is presented. A number of statistical evaluations show that the forecasts have enough skill to be useful for end users. A few areas of systematic bias and relatively higher forecast error were identified for further improvement in forecast skill.