bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments
Authors: Redman Aaron D. , Parkerton Thomas F. , Paumen Miriam Leon , McGrath Joy A. , den Haan Klaas , Di Toro Dominic M. 
Published: September 2014

Abstract

Substance risk assessments require estimation of predicted no-effect concentrations (PNECs) in soil and sediment. The present study applies the target lipid model (TLM) and equilibrium partitioning (EqP) model to toxicity data to evaluate the extrapolation of the TLM-derived aquatic PNECs to these compartments. This extrapolation assumes that the sensitivity of aquatic species is similar to that of terrestrial and benthic species. The acute species sensitivity distribution, expressed in terms of species-specific critical target lipid body burdens, was computed using the TLM-EqP framework and found to span a similar range as the aquatic organism species sensitivity distribution but with a slightly lower median value (less than 2 times). The species sensitivity distribution for acute-to-chronic ratios also exhibited a similar range and distribution across species, suggesting similar mechanisms of action. This hypothesis was further tested by comparing empirical soil/sediment chronic effect levels to the calculated PNEC derived using TLM-EqP. The results showed that 95% of the compiled chronic effects data fell above the PNEC, confirming an adequate protection level. These findings support the conclusion that TLM-derived aquatic PNECs can be successfully extrapolated to derive credible PNECs for soil and sediment compartments. Environ Toxicol Chem 2014;33:2679–2687. © 2014 SETAC
HPV‐related oropharyngeal cancer: Risk factors for treatment failure in patients managed with primary transoral robotic surgery
Authors: Kaczmar John M. , Tan Kay See , Heitjan Daniel F. , Lin Alexander , Ahn Peter H. , Newman Jason G. , Rassekh Christopher H. , Chalian Ara A. , O'Malley Bert W. , Cohen Roger B. , Weinstein Gregory S. 
Published: September 2014

ABSTRACTBackgroundThe purpose of this study was to determine clinical factors that predict locoregional recurrence or distant metastasis in patients with human papillomavirus (HPV)‐positive oropharyngeal cancer treated with surgery and guideline‐indicated adjuvant therapy.MethodsWe identified all presumed HPV‐positive patients with oropharyngeal cancer in our health system from January 2010 to August 2012 treated with surgery and guideline‐indicated adjuvant therapy. Statistical analysis was performed to identify clinical predictors associated with treatment failure.ResultsOne hundred fourteen p16+ oropharyngeal cancers managed with initial surgical resection were identified. Median follow‐up was 17 months. Two‐year locoregional failure was 3.3% and distant failure was 8.4%. Statistical analysis found that conventional poor prognostic features did not predict treatment failure.ConclusionLocoregional recurrence and development of distant metastatic disease are uncommon in patients who are appropriately selected for surgical management of p16+ oropharyngeal cancer regardless of the presence or absence of conventional poor prognostic features. © 2015 Wiley Periodicals, Inc. Head Neck 38: 59–65, 2016
SALES, INVENTORIES AND REAL INTEREST RATES: A CENTURY OF STYLIZED FACTS
Authors: Benati Luca , Lubik Thomas A. 
Published: September 2014

SUMMARYWe use Bayesian time‐varying parameter structural vector autoregressions with stochastic volatility to investigate changes in reduced‐form and structural correlations between inventories and either sales growth or the real interest rate in the USA during both the inter‐war and post‐World War II periods. We identify four structural shocks by combining a single long‐run restriction to identify a permanent output shock with three sign restrictions to identify demand‐ and supply‐side transitory shocks. We show that during both the inter‐war and post‐war periods the structural correlation between inventories and real interest rate conditional on identified interest rate shocks is systematically positive; the reduced‐form correlation between the two series is positive during the post‐war period, but in line with the predictions of theory it is robustly negative during the inter‐war era; during that era the correlations between inventories and either of the two other series exhibit a remarkably strong co‐movement with output at business cycle frequencies. Copyright © 2014 John Wiley & Sons, Ltd.
Heparinized PLLA/PLCL nanofibrous scaffold for potential engineering of small‐diameter blood vessel: Tunable elasticity and anticoagulation property
Authors: Wang Weizhong , Hu Jinwei , He Chuanglong , Nie Wei , Feng Wei , Qiu Kexin , Zhou Xiaojun , Gao Yu , Wang Guoqing 
Published: September 2014

AbstractThe success of tissue engineered vascular grafts depends greatly on the synthetic tubular scaffold, which can mimic the architecture, mechanical, and anticoagulation properties of native blood vessels. In this study, small‐diameter tubular scaffolds were fabricated with different weight ratios of poly(l‐lactic acid) (PLLA) and poly(l‐lactide‐co‐ɛ‐caprolactone) (PLCL) by means of thermally induced phase separation technique. To improve the anticoagulation property of materials, heparin was covalently linked to the tubular scaffolds by N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide hydrochloride and N‐hydroxysuccinimide coupling chemistry. The as‐prepared PLLA/PLCL scaffolds retained microporous nanofibrous structure as observed in the neat PLLA scaffolds, and their structural and mechanical properties can be fine‐tuned by changing the ratio of two components. The scaffold containing 60% PLCL content was found to be the most promising scaffold for engineering small‐diameter blood vessel in terms of elastic properties and structural integrity. The heparinized scaffolds showed higher hydrophilicity, lower protein adsorption ability, and better in vitro anticoagulation property than their untreated counterparts. Pig iliac endothelial cells seeded on the heparinized scaffold showed good cellular attachment, spreading, proliferation, and phenotypic maintenance. Furthermore, the heparinized scaffolds exhibited neovascularization after subcutaneous implantation into the New Zealand white rabbits for 1 and 2 months. Taken together, the heparinized PLLA/PLCL nanofibrous scaffolds have the great potential for vascular tissue engineering application. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1784–1797, 2015.
Tubular perfusion system for chondrocyte culture and superficial zone protein expression
Authors: Yu Li , Ferlin Kimberly M. , Nguyen Bao‐Ngoc B. , Fisher John P. 
Published: September 2014

AbstractTissue engineering is an alternative method for articular cartilage repair. Mechanical stimulus has been found to be an important element to the healthy development of chondrocytes and maintenance of their native phenotype. To enhance nutrient transport and apply mechanical stress, we have developed a novel bioreactor, the tubular perfusion system (TPS), to culture chondrocytes in three‐dimensional scaffolds. In our design, chondrocytes are encapsulated in alginate scaffolds and placed into a tubular growth chamber, which is perfused with media to enhance nutrient transfer and expose cells to fluid flow. Results demonstrate that TPS culture promotes the proliferation of chondrocytes compared to static culture as shown by DNA content and histochemical staining. After 14 days of culture, low messenger RNA expression of proinflammatory and apoptotic markers in TPS bioreactor culture confirmed that a flow rate of 3 mL/min does not damage the chondrocytes embedded in alginate scaffolds. Additionally, cells cultured in the TPS bioreactor showed increased gene expression levels of aggrecan, type II collagen, and superficial zone protein compared to the static group, indicative of the emergence of the superficial zone specific phenotype. Therefore, the TPS bioreactor is an effective means to enhance the proliferation and phenotype maintenance of chondrocytes in vitro. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1864–1874, 2015.
Ventricular septal rupture, right ventricular dissection, and tricuspid chordae rupture—A rare complication after inferior and right ventricular infarction
Authors: Li Xiao‐hong , Zhao Ying , Dong Jianzeng , He Yihua , Liu Wenxu , Han Jiancheng 
Published: September 2014

ABSTRACTA 76‐year‐old man under stable hemodynamic condition was admitted to our hospital for delayed percutaneous coronary intervention following a diagnosis of acute inferior myocardial infarction. Bedside echocardiography revealed ventricular septal rupture at the basal posteroinferior wall with a large left‐to‐right shunt. Right ventricular free‐wall intramyocardial dissection and tricuspid chordae rupture were noted. Coronary angiography demonstrated occlusion of the proximal right coronary artery, which was treated by balloon angioplasty and stenting. While preparing for surgical repair, the patient's overall cardiac and renal function deteriorated and surgery was contraindicated. The patient died 16 days after discharge. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 43:512–515 2015
Simplified dipole concept for the assessment of transient electromagnetic field in the vicinity of grounding grid
Authors: Chouki Makhlouf , Nekhoul Bachir , Poljak Dragan , Kerroum Kamal , Drissi Khalil El Khamlichi 
Published: September 2014

AbstractThe objective of this work is to provide a simplified model to analyse the electromagnetic emission of the grounding grid thus enabling engineers to perform parametric studies rapidly without greater loss of accuracy. The proposed approach is based on the use of the transmission line theory and the concept of dipole radiation in the presence of a lossy half‐space including the Sommerfeld integral approach. The model proposes to determine the electromagnetic fields (soil and air) and current distribution in a grounding system. The proposed model is described and illustrated with applications. The limitations and advantages are also discussed and compared against antenna theory counter parts. Copyright © 2014 John Wiley & Sons, Ltd.
Deglycosylation of isoflavone C‐glycosides by newly isolated human intestinal bacteria
Authors: Kim Mihyang , Lee Jaekwan , Han Jaehong 
Published: September 2014

AbstractBACKGROUNDPlant isoflavones are mostly present in the glycoside form. Isoflavone aglycones produced by intestinal microflora are reported to be more bioactive than the glycoside form. However, the deglycosylation of isoflavone C‐glycosides is known to be rare, and is less studied.RESULTSThree new bacteria were isolated from human faecal samples, two of which hydrolysed the C‐glycosidic bond of puerarin, daidzein‐8‐C‐glucoside. They were identified as two Lactococcus species, herein designated as MRG‐IFC‐1 and MRG‐IFC‐3, and an Enterococcus species, herein designated MRG‐IFC‐2, based on their 16S rDNA sequences. From a reactivity study, it was found that Lactococcus sp. MRG‐IFC‐1 and Enterococcus sp. MRG‐IFC‐2 hydrolysed isoflavone C‐ and O‐glycosides, as well as the flavone O‐glycoside apigetrin, but could not hydrolyse the flavone C‐glycosidic bond of vitexin. The other Lactococcus sp., MRG‐IF‐3, could not hydrolyse the C‐glycosidic linkage of puerarin, while it showed a broad substrate spectrum of O‐glycosidase activity similar to the other two bacteria. Puerarin was completely converted to daidzein within 100 min by Lactococcus sp. MRG‐IFC‐1 and Enterococcus sp. MRG‐IFC‐2, which is the fastest conversion among the reported human intestinal bacteria.CONCLUSIONTwo new puerarin‐metabolising human intestinal bacteria were isolated and identified, and the deglycosylation activity for various flavonoid glycosides was investigated. The results could facilitate the study of C‐glycosidase reaction mechanisms, as well as the pharmacokinetics of bioactive C‐glycoside natural products. © 2014 Society of Chemical Industry
Efficiency of Artemisia nilagirica (Clarke) Pamp. essential oil as a mycotoxicant against postharvest mycobiota of table grapes
Authors: Sonker Nivedita , Pandey Abhay K , Singh Pooja 
Published: September 2014

AbstractBACKGROUNDIn order to get a potent botanical fungicide for the management of fungal decay of table grapes, an experiment was conducted in which 20 essential oils of higher plants were screened at 0.33 µL mL−1 against dominant fungi causing decay of table grapes, including Aspergillus flavus, A. niger and A. ochraceus. Furthermore, the minimum inhibitory/fungicidal concentration, fungitoxic spectrum and mycotoxin inhibition activity of the most potent oil were determined. The efficacy of the most potent oil in preservation of table grapes, along with organoleptic evaluation, was also carried out by storing 1 kg of grapes in the oil vapour.RESULTSArtemisia nilagirica oil was found to be most toxic, exhibiting 100% mycelia inhibition of all test fungi. Moreover, 0.29 µL mL−1 A. nilagirica oil was fungistatic and 0.58 µL mL−1 was fungicidal for all tested species of Aspergillus. The oil exhibited a broad range of fungitoxicity against other grape berry‐rotting fungi. Artemisia nilagirica oil completely suppressed the growth and mycotoxin (AFB1 and OTA) secretion of aflatoxigenic and ochratoxigenic strains of Aspergillus at 1.6 µL mL−1. During the in vivo experiment, fumigation of 1 kg of table grapes with 200 and 300 µL dosage of A. nilagirica oil enhanced the shelf life for up to 9 days. The oil did not show any phytotoxic effect. Besides, oil application did not substantively change the sensory properties of the fruits.CONCLUSIONArtemisia nilagirica oil can be used as an alternative botanical fungicide for the control of fruit‐rotting fungi of stored grapes. © 2014 Society of Chemical Industry
Nothing Less Than More Affordable Lithium‐Ion Batteries
Authors: Walter Dmitrij , Schmieder Benjamin , Moldovan Vasil Raul 
Published: September 2014

AbstractE‐Mobility will only become established when the energy storage units required in the car become more affordable – on this point the experts agree. The key here is lowering production costs. To accomplish this, the high‐tech engineering company Manz is relying on a new type of laser welding in the production of lithium‐ion batteries which is raising the bar for the quality of welding seams, process stability, and the required output of the beam source.
Keyhole Depth is just a Distance
Authors: Bautze Thibault , Kogel‐Hollacher Markus 
Published: September 2014

AbstractTalking about laser welding predominately means talking about the generation of a keyhole, the physics behind and invariably the depth of this steam capillary. Having the ability to measure this depth would undoubtedly raise the confidence in laser welding and also raise the quality of the processed part on a higher level.
Neurotized sural flap: An alternative in sensory reconstruction of the foot and ankle defects
Authors: Tan Onder , Aydin Osman E. , Demir Recep , Barin Ensar Z. , Cinal Hakan , Algan Said 
Published: September 2014

IntroductionThe sensory reconstruction of the lower extremity is one of the main goals in lower extremity reconstruction. Reconstructive options endowing sensory recovery are limited. The aim of this report is to evaluate the neurotized sural flap in reconstruction of foot and ankle defects.Patients and MethodsSeven cases that were operated for foot and ankle skin defects with the neurotized sural flap were reported. The largest flap was 10 cm × 14 cm in size. Median age was 38 years. Four defects were on the heel, two were on the ankle, and one was on the dorsum of the foot. The sural nerve was coaptated to a recipient nerve in seven patients.ResultsAll flaps survived totally. Follow‐up time ranged between 9 and 29 months. All cases had hot–cold perception and two‐point discrimination at average 14 ± 1.63 mm at 6th month. Sensory conduction test revealed very low action potentials related to stimulation of the flap.ConclusionThe neurotized sural flap is a versatile modification, for the sensory reconstruction of the moderate size foot and ankle defects. © 2014 Wiley Periodicals, Inc. Microsurgery 35:183–189, 2015.
Resolving confounding enrichment kinetics due to overlapping resonance signals from 13C‐enriched long chain fatty acid oxidation and uptake within intact hearts
Authors: O'Donnell J. Michael , Fasano Matthew J. , Lewandowski E. Douglas 
Published: September 2014

PurposeLong chain fatty acid (LCFA) oxidation measurements in the intact heart from 13C‐NMR rely on detection of 13C‐enriched glutamate. However, progressive increases in overlapping resonance signal from LCFA can confound detection of the glutamate 4‐carbon (GLU‐C4) signal. We evaluated alternative 13C labeling for exogenous LCFA and developed a simple scheme to distinguish kinetics of LCFA uptake and storage from oxidation.MethodsSequential 13C‐NMR spectra were acquired from isolated rat hearts perfused with 13C LCFA and glucose. Spectra were evaluated from hearts supplied: U 13C LCFA, [2,4,6,8,10,12,14,16‐13C8] palmitate, [2,4,6,8,10,12,14,16,18‐13C9] oleate, [4,6,8,10,12,14,16‐13C7] palmitate, or [4,6,8,10,12,14,16,18‐13C8] oleate.Results13C signal reflected the progressive enrichment at 34.6 ppm from GLU‐C4, confounded by additional signal with distinct kinetics attributed to 13C‐enriched LCFA 2‐carbon (34.0 ppm). Excluding 13C at the 2‐carbon of both palmitate and oleate eliminated signal overlap and enabled detection of the exponential enrichment of GLU‐C4 for assessing LCFA oxidation.ConclusionEliminating enrichment at the 2‐carbon of 13C LCFA resolved confounding kinetics between GLU‐C4 and LCFA 2‐carbon signals. With this enrichment scheme, oxidation of LCFA, the primary fuel for cardiac ATP synthesis, can now be more consistently examined in whole organs with dynamic mode, proton‐decoupled 13C‐NMR. Magn Reson Med 74:330–335, 2015. © 2014 Wiley Periodicals, Inc.
Manifold Learning in MR spectroscopy using nonlinear dimensionality reduction and unsupervised clustering
Authors: Yang Guang , Raschke Felix , Barrick Thomas R. , Howe Franklyn A. 
Published: September 2014

PurposeTo investigate whether nonlinear dimensionality reduction improves unsupervised classification of 1H MRS brain tumor data compared with a linear method.MethodsIn vivo single‐voxel 1H magnetic resonance spectroscopy (55 patients) and 1H magnetic resonance spectroscopy imaging (MRSI) (29 patients) data were acquired from histopathologically diagnosed gliomas. Data reduction using Laplacian eigenmaps (LE) or independent component analysis (ICA) was followed by k‐means clustering or agglomerative hierarchical clustering (AHC) for unsupervised learning to assess tumor grade and for tissue type segmentation of MRSI data.ResultsAn accuracy of 93% in classification of glioma grade II and grade IV, with 100% accuracy in distinguishing tumor and normal spectra, was obtained by LE with unsupervised clustering, but not with the combination of k‐means and ICA. With 1H MRSI data, LE provided a more linear distribution of data for cluster analysis and better cluster stability than ICA. LE combined with k‐means or AHC provided 91% accuracy for classifying tumor grade and 100% accuracy for identifying normal tissue voxels. Color‐coded visualization of normal brain, tumor core, and infiltration regions was achieved with LE combined with AHC.ConclusionThe LE method is promising for unsupervised clustering to separate brain and tumor tissue with automated color‐coding for visualization of 1H MRSI data after cluster analysis. Magn Reson Med 74:868–878, 2015. © 2014 Wiley Periodicals, Inc.
An analytical solution for deforming twin‐parallel tunnels in an elastic half plane
Authors: Fu Jinyang , Yang Junsheng , Yan Li , Abbas Syed Muntazir 
Published: September 2014

SummaryThe interaction between twin‐parallel tunnels affects the tunnelling‐induced ground deformation, which may endanger the nearby structures. In this paper, an analytical solution is presented for problems in determining displacements and stresses around deforming twin‐parallel tunnels in an elastic half plane, on the basis of complex variable theory. As an example, a uniform radial displacement was assumed as the boundary condition for each of the two tunnels. Special attention was paid to the effects of tunnel depth and spacing between the two tunnels on the surface movement to gain deep insight into the effect of the interaction between twin‐parallel tunnels using the proposed analytical approach. It is revealed that the influence of twin tunnel interaction on surface movements diminishes with both the increase of the tunnel depth and the spacing between the two tunnels. The presented analytical solution manifests that, similar to most of the existing numerical results, the principle of superposition can be applied to determine ground deformation of twin‐parallel tunnels with a certain large depth and spacing; otherwise, the interaction effect between the two tunnels should be taken into account for predicting reliable ground movement. Copyright © 2014 John Wiley & Sons, Ltd.
Preparation and characterization of narrow compositional distribution polyampholytes as potential biomaterials: Copolymers of N‐(3‐aminopropyl)methacrylamide hydrochloride (APM) and methacrylic acid (MAA)
Authors: Dubey Ankita , Burke Nicholas A. D. , Stöver Harald D. H. 
Published: September 2014

ABSTRACTThis article describes the preparation and solution properties of a series of polyampholytes composed of N‐(3‐aminopropyl)methacrylamide hydrochloride (APM) and methacrylic acid (MAA). In particular, conditions were found where the copolymers could be formed with little or no drift in composition over the course of polymerization to quite high conversions. The compositional drift, common to many copolymerizations, was limited by adjusting the reactivity of MAA through control of its degree of ionization (i.e., pH). As revealed by potentiometric measurements and changes in 1H NMR spectra, the solution pH drifted over the course of some polymerizations. This was ascribed to changes in the pKa values of the ammonium and carboxylate groups upon incorporation in the copolymer. The pH drift led to a change in degree of MAA ionization, and hence the relative reactivities of APM and MAA, but this effect could be minimized by using a buffer. Precipitation, which occurred during some polymerizations, could be prevented, in some cases, by the addition of salt or an organic cosolvent. Even in cases where precipitation could not be prevented, it was found that the copolymer was still formed with minimal compositional drift. The solubility of the resulting polyampholytes in aqueous solution was found to depend on their composition, as well as pH, ionic strength and temperature. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 353–365