bluuebunny/crossref_metadata_2025_split huggingface dataset:
1052 – Assessment Of The Degree Of Dependence According To The Principles Of The Icf Concerning People Suffering From Mental And Behavioural Disorders
Authors: Čeledová L. , Čevela R. , Ptáček R. , Kuželová H. 
Published: July 2013

IntroductionSince 2007, there has been a gradual increase in the total number of the institutionally approved dependency regarding mental disorders (21 596 cases in 2007, 24 317 cases in 2011). The newly proposed criteria of the assessment of the degree of dependence from January 1, 2012 are set according to the principles of the International Classification of Functioning, Disability and Health (ICF). The aim was to take into account the social needs of patients suffering from mental disorders.Ten basic needsThe assessment of the degree of dependence includes the evaluation of the functional impact of the longterm unfavourable state of health on the ability to manage the 10 basic needs. The basic needs are further specified by the ICF principles and activities. Prior to the adoption of this method, assessing the degree of dependence had been tested in terms of its functionality, reliability and impact on disabled people. The tests have demonstrated moderate benefits of this method for people suffering from mental disorders.[The 10 basic needs in the ICF classification].MobilityChapter 4 Mobility, such as d 450 Walking, d 460, d 410OrientationChapter 1 Learning and applying knowledge, such as codes d 110 - 129CommunicationChapter 3 Communication, d 310 - d 360Self-feedingChapter 5 Self-care, eating and drinking, d 550 - 560Putting on clothes and footwearChapter 5 Self-care, d 540Washing oneselfChapter 5 Self-care, d 510 - 520ToiletingChapter 5 Self-care, d 530Looking after one's healthChapter 5 Self-care, d 570, Chapter 2 General tasks and demands, such as d 230Personal activitiesChapter 8 Major life areas, such as d 810 - 820, Chapter 9 Community, social and civic life, such as d 910 - 920Household tasksChapter 6 Domestic life, such as d 630 - 640ConclusionThe method in question provides an efficient interconnection within the ICF application in both healthcare and dependence degree assessment. Thus, the reflection of ICF in new medical assessment criteria used to assess the degree of dependence will contribute to a change in how healthcare professionals perceive disabilities, and it will ensure that the areas of healthcare, aftercare or long-term care, and the social area are combined more effectively.
1054 – Assessment Of Health And Working Capacity Of People With Dementia For Purposes Of The Social Security System
Authors: Čevela R. , Čeledová L. , Ptáček R. , Kuželová H. 
Published: July 2013

IntroductionA new approach to health assessment and the rate of working capacity decline of patients suffering from dementia, is based on the results (as of January 1, 2010) of a project entitled: Advances in medical science reflected in functional health state assessment and working incapacity in relation to International Classification of Diseases and International Classification of Functioning, Disability and Health.Disability due to dementiaThe total number of hospitalizations due to dementia (F01, F03, G30) increased by more than one fifth (from 6549 to 7981 hospitalizations) between 2006 and 2010. However, the overall number of disabilities between 2006 and 2009 decreased by one half (from 2998 to 1571), and between 2010 and 2011 dropped to 5% of its original number (190 and 144 cases respectively). Nevertheless, between 2007 and 2011, there was a 50% increase in the number of patients with institutionally confirmed disabilities (from 6270 to 9504).Conclusion The new approach to incapacity assessment is in accordance with medical experts' opinions and advances in medical science, related to function ability, activity and participation.The new way of incapacity assessment could be the reason for the dramatic decrease in the number of institutionally confirmed disabilities in 2010 and 2011, despite the growing number of patients suffering from dementia.Such discrepancy may also be explained by early diagnostics and more effective treatment, which prevent patients with dementia from becoming disabled.Moreover, this hypothesis corresponds to the increasing number of patients with a certain degree of dependence due to dementia.
1057 – Evaluation Of Quality Of Life, Psychosocial Functioning, And Medication Adherence Among Patients Switched To Lurasidone From Other Antipsychotics
Authors: Awad G. , Hassan M. , Loebel A. , Hsu J. , Pikalov A. , Rajagopalan K. 
Published: July 2013

IntroductionPatient reported outcomes (PROs), i.e. quality of life (QoL), psychosocial functioning and medication adherence are vital assessments of results in schizophrenia treatment.ObjectivesQuality of life, psychosocial functioning and adherence attitude were evaluated among adult patients with schizophrenia switched from current antipsychotics to lurasidone, using the Personal Evaluation of Transitions in Treatment (PETiT) scale, a PRO measure.AimsEvaluate PROs after switching to lurasidone.MethodsStable but symptomatic adult outpatients with schizophrenia were switched from their previous antipsychotics to lurasidone, in a 6-week, open-label trial. Subjective responses to antipsychotic therapy were evaluated at baseline and study endpoint using PETiT (Higher scores=better outcomes). Score change was obtained for all patients and those switched from “sedating” (olanzapine, quetiapine) or “non-sedating” (risperidone, aripriprazole, ziprasidone, others) agents. Change from baseline to endpoint in total (overall QoL) and subscale scores (psychosocial functioning, adherence attitude) were compared using ANCOVA.ResultsOf the 244 patients switched to lurasidone, 213 had available data. Changes from baseline in mean total PETiT score (3.2, P< 0.0001) and subscale scores of psychosocial functioning (2.5) and adherence attitude (0.7) were reported in all patient groups (p< 0.001). Improvement in mean total PETiT score was observed in patients switched from non-sedating (3.5, n=139) and sedating (2.7, n=74) antipsychotics and was statistically significant (P< 0.0001) in the non-sedating group. Differences in statistical significance (sedating vs non-sedating) may arise from smaller changes, not sample size.ConclusionsIn this study, patients switching to lurasidone experienced improvement in QoL, psychosocial functioning and adherence attitude.
1059 – Clinical Psychiatric Research School
Authors: Okkels N. , Ahlers F.S. , Andersson N.A.W. , Harboe L.F. , Knudsen M.S. , Lundberg A.S. , Midtgaard J. , Okkels A.S.L. , Munk-Jørgensen P. ,   Clinical Psychiatric Research School
Published: July 2013

IntroductionDuring the past three decades psychiatry has suffered from a decline in the recruitment of young physicians across Europe. The challenges for clinical psychiatric research are even worse. After psychiatry has declared itself a medical (neuro) speciality the situation is now shifting towards the better.Active innovation programs are however needed to accelerate this recent positive trend.ObjectiveTo introduce and train medical students in clinical psychiatric research methodology by practical research work supported by theoretical teaching.AimsTo describe a local initiative done by AUH Risskov, Department M in Denmark implementing a clinical research teaching program for medical students.MethodsWe invited students of medicine known as dedicated and pro-active and posted the program on our website. Students responding positively to our invitation were interviewed by the first and senior author before being accepted into the program.ResultsThe group consists of 8 medical students and one psychology student in their third to the tenth term (of 12) at university. They are all given minor research questions relevant to the clinical department. The trainees are supervised in groups and individually parallel to systematic teaching. Further details will be given at the presentation.We have deliberately sought out the most qualified students with an elitist approach. The participants commit themselves to act in an active, independent and disciplined way when accepted into the program.The participants will be present at the Nice congress ready for discussion and with answers to any questions about the program.
1060 – The Role Of Clinical And Dimensional Personality Factors On Chronic Medical Comorbidty In Patients With Major Depressive Disorder
Authors: Enatescu V.R. , Enatescu I. , Enatescu V. , Romosan R.S. , Papava I. , Ienciu L.M. 
Published: July 2013

IntroductionMajor depressive disorder, the most prevalent psychiatric disorder in general population, raises a series of clinical challenges, chronic medical comorbidity being regular one.ObjectivesOur main objective was to analyze the weight of anxiety and depressive symptoms levels, and that of premorbid personality traits, in co-occurrence of medical diseases in subjects with major depressive disorder.MethodsA cross-sectional research was performed on 32 inpatient subjects admitted in Timisoara Psychiatric Clinic during 2010 - 2012 with major depressive disorder. Anxiety symptoms level were self-assessed with Beck Anxiety Inventory and depressive symptoms level were self-assessed with Beck Depression Inventory. Temperament and character personality traits were self-assessed using Cloninger TCI tool, which was administrated once that clinical remission has occurred.ResultsMajority of studied subjects (71%) have had at least one comorbid chronic medical diseases. Despite the results of other studies, the level of depressive and anxiety symptoms has no significant impact in medical comorbidity occurrence. Major depressive subjects with medical comorbidity, have had significant higher scores in Harm Avoidance, more exactly in Shyness with Strangers (p = 0.007) and Fatigability (p = 0.013). Significant higher total scores were revealed, in the same subjects, for all three character dimensions like as Self-Directedness (p = 0.004), Cooperativeness (p = 0.039) and Self-Transcendence (p = 0.030).ConclusionsAccording to our research results, rather than temporary clinical symptoms constituting clinical picture of subjects with major depression there is possible that premorbid personality traits could weigh more significant to the appearance of medical comorbid conditions.
1062 – Predictors For Remission Of Major Depression And Anxious Disorders And For Developing Disorders In An Epidemiologic Catchment Area In Montreal, Canada: a Longitudinal Study
Authors: Caron J. , Aihua L. ,   Équie des IRSC en Épidémiologie Sociale et Psychiatrique
Published: July 2013

ObjectivesThe aim of this study is identifying the predictors of major depression and anxiety disorders and the predictors of the remission of these disorders.MethodsA longitudinal study under the form of a community survey includes a randomly selected sample of 2,434 individuals between 15 and 65 years of age (T1); 1,815 agreed to be re-interviewed two years later (T2). Mental disorders were identified with the Composite International Diagnostic Interview, including mood disorders (major depression, and mania), and some anxiety disorders: panic disorder (PD), social phobia (SP), and agoraphobia (AG). Logistic regression was used to identify predictors (T1) of remission of mood disoders and anxiety disorders at T2 and predictor of new cases at T2.ResultsThe prevalence of mental disorders for the two waves of the research program will be presented. For major depression (MD), among the 145 subjects who had MD at T1, 69% recovered at T2 and among the 1553 that did not have MD at T1, 5.7% developed MD at T2. For anxiety disorders, among the 93 subjects who had these disorders at T1, 78.4% recovered at T2 and among the 1635 subjects who were free of an anxiety disorder at T1, 1.8% developed it at T2. Predictors identified for remission of disorders and for developing new disorders at T2 will be presented.ConclusionThe predictors of new cases identified will allow to develop more effective prevention program and those associated to remissions will help to improve mental health services.
1064 – Does Internet Promote Self-harm Behavior?
Authors: Guerra C. , Ferreira P. , Moura M. , Silva A. 
Published: July 2013

IntroductionSelf-harm is a major public health problem, being a frequent condition among youth and young adults. Psychiatric conditions, like borderline personality, depression, substance misuse and anxiety disorders, are commonly associated with self-harm. The effects of media and contagion are also important and the internet has an important role in divulging and sharing self-harm behaviors.AimsWe pretend to study the role the internet in potentiating or preventing self-harm behaviors.MethodsWe used combined literature searches in PubMed and B-on using the terms “self-harm”, “self injury”, “self mutilation” and “internet” and we also present a clinical case from our service.ResultsMost of the individuals that have self-harm behaviors may never present in psychiatric ward. Today, there is more information about self-harm available to the public domain than ever and web sites about self-harm include personal pages, forums, blogs, communities and even video-sharing sites. These web sites have supportive content that allow the users feeling that they are not alone, sharing feelings and narratives. However, most of them have potentially harmful material, including self-injury related tips, reinforcing messages and triggering material, normalizing or even glamorizing self-injury.ConclusionsMost of the websites normalize and promote self-harm behaviors. Only the better knowledge of these phenomena would allow the use of internet as an effective tool for self-harm prevention, especially for socially-isolated and vulnerable individuals.
1066 – Inflammation As Common Denominator Of Ed And Mdd
Authors: Khan M.H. , Mukhtar M.Z. , Javad R. , Naiz S. 
Published: July 2013

IntroductionComorbidity between ED and depression is high. Causal relation between two is bidirectional. Person with ED can have MDD because of psychological factors. MDD symptoms and associated hypogonadism affect on libido and erectile function. Diseases like ankolysing spondolysis, asthma, rheumatoid arthritis, coronary heart disease, psoriasis, diabetes, and multiple sclerosis have strong co morbid ED and MDD. Inflammation is common overlapping factor in these illnesses.MethodAn internet search was made on pubmed, and psychiatrist.com, using key words, major depression, endothelial dysfunction, inflammation, erectile dysfunction, and cytokines. This was followed by study of relevant martial in different journal and books.ResultMen with ED had high levels of depressive, somatic, and anxious symptoms. Approximately one-third of people with MDD had higher levels of peripheral inflammatory marker. Incidences of ED are two fold higher in depressed people as compared with nondepressed.DiscussionLevels of pro inflammatory cytokine like IL-1,I patient L-6,TNF,CRP, interferon-gamma and homosystien are raised in MDD. Cytokines effect on the HPA axis, glucocorticoid resistance, neurotransmission and hippocampal neurogenesis. Patients treated with interferon have higher risk of developing MDD .Antidepressant therapy results in decreased inflammatory response.Erectile function depends on integrity of endothelium which is target of inflammation. Endothelial dysfunction is linked to ED as they share a common pathway through the release of nitric oxide. Proinflammatory cytokines and homosystien play role, both in ED and MDD.ConclusionInflammation and its markers need to be considered in cases of co morbid ED and MDD.
1070 – Expression Of Caspase-12 And Grp94 In Medial Prefrontal Cortex Of Ptsd Rats
Authors: Zhao D. , Han F. , Shi Y. 
Published: July 2013

IntroductionPost-traumatic stress disorder is an important manifestation of mental and behavioral disorders after the disaste Single-prolonged stress (SPS) is an received established animal model for post-traumatic stress disorder.ObjectivesTo investigate endoplasmic reticulum apoptosis pathway and unfolded protein reaction plays an important role in medial Prefrontal Cortex of PTSD rats by Single-prolonged stress (SPS).AimsDetermined by the change of free intracellular Ca2+ the glucose-regulated Protein (GRP)94 and apoptosis-related cacaspase-12 expression.MethodsA total of 60 healthy, male Wistar rats were selected for this study,randomly divided into a normal control group and SPS groups of 1d,4d,7d,14day and 28day. Behavioral of learning and memory capabilities of rats was observed by using Morris water maze. The expression of, GRP94 and cacaspase-12 was detected using immunohistochemical,Western Blotting and reverse transcription-polymerase chain reaction.ResultsIn this study compared with control groups the intracellular free calcium level in mPFC was increased 1 day after SPS exposure (P< 0.05) decreased 7 days after SPS. The expression cacaspase-12 peaked at SPS 7d and then gradually decreased. GRP94 express in normal control group and increased 1 day after SPS exposure peaked at SPS 7d and then gradually decreased, at SPS 28d still higher than normal control group.ConclusionsIn SPS-PTSD rats the learning and memory capabilities of the rats decline;mPFC free intracellular Ca2+ may relate to endoplasmic reticulum stress;Endoplasmic reticulum stress launch unfolded protein reaction Endoplasmic reticulum apoptotic process which may relate to the pathogenesis of medial prefrontal cortex abnormal function in PTSD.
1072 – OPRM1 Gene Polymorphisms In Opioid Addiction
Authors: González D. , Cañadas M. , Aguilera M. , Reyes J.A. , Calleja M.Á. , Plaza A. 
Published: July 2013

IntroductionOpioid addiction is a serious health/social problem, associated with high morbidity and mortality.Several gene polymorphisms on the mu-opioid receptor gene(OPRM1), which plays an important role in reward system, have been related to opioid dependence (A118G, C17T, C2044A). A118G is the most studied and probably the most promising biomarker of better response in these patients, despite discrepancies has been manifested even in studies conducted on the same ethnicity.Objectives and aimsDescription of A118G, C17T and C2044A allele frequencies in an opioid-dependent population. Evaluation of the association of A118G gene polymorphism with opioid dependence.MethodsCase-control Study.Case group: 16 patients with opioid addiction, included in a Heroin Prescription Program in Andalusia, based on the protocolized individual prescription of diacetylmorphine. Control group: 32 non opioid-dependent subjects.Genotyping of A118G, C17T and C2044A was performed by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism.ResultsCase group: 12 patients were AA homozygous (12/16;75%) and 4 patients were heterozygous AG (4/12;25%) for A118G. All patients were homozygous CC for C17T and C2044A (16/16;100%). The distribution of the genotype frequencies of OPRM1 gene polymorphisms in the case series were not statistically different from those reported for European populations in HapMap for A118G (p=0.6418) and the GENO PANEL for C17T. Control group:19 patients were AA homozygous(19/32; 59.4%) and 13 patients were heterozygous AG (13/32;40.6%) for A118G. This polymorphism was not associated to opioid addiction (p=0.3503).ConclusionsDistribution of genotype frequencies in opioid dependants corresponded to specific frequencies from European population for A118G and C17T polymorphisms. OPRM1 gene polymorphisms were not associated to opioid addiction in this population.
1073 – Assessment Of Behavioral Symptoms In Dementia Patients With The Help Of Icts
Authors: König A. 
Published: July 2013

IntroductionBehavioral and psychological symptoms in dementia patients (BPSD), represent a strong predictor of dementia progression. Current interview-based assessment methods lack objectivity to ensure reliable early differential detection. Therefore, the use of Information and Communication Technologies (ICT) such as actigraphy and automatized video monitoring are of interest in addition to current assessment methods because they allow capturing the patients’ performances and actions in real time and real life situations.ObjectivesTo improve the quality of clinical assessments of BPSD by validating the use of objective measurements obtained by ICTs in dementia patients in an experimental design, undergoing an „ecological assessment“.MethodsDemented and pre-demented patients (with and without apathy) and healthy controls underwent an experimental trial wearing an actigraph and being filmed over a free period of 15 minutes in a in 16-zone divided room. Apathy was assessed using NPI apathy subscore. Frequency of zone displacement, and of goal-oriented zones, object manipulation, mean motor activity and speed of walking were assessed with the help of ICT.ResultsSignificant differences were found between apathy and non-apathy AD patients for the parameter of object manipulation (OM) and OM in goal-oriented zones (GOZ) but not for frequency of zone displacement (FZD).ConclusionsModerate evidence for a reliable detection of apathy in dementia patients through data obtained by ICTs was found. Therefore, it represents a promising addition to conventional neuropsychological methods for future studies, focusing in particular on object manipulation and visuomotor deficits.
1078 – Is There Evidence For a Link Between Stress And Addiction?
Authors: Christoforou R. , Hagan C.C. , Jones P.S. , Williams G.B. , Ersche K.D. ,   KD Ersche s Addiction Research Lab
Published: July 2013

IntroductionStress and reward processing are two of the principal mechanisms involved in the modulation of homeostasis in the body. According to neurobiological research, these two mechanisms overlap in the cortico-striatal-limbic circuit, which can be disrupted due to chronic stress and substance abuse. Stress is primarily modulated by the hypothalamic-pituitary-adrenal (HPA) axis, from which cortisol is an end-product.ObjectivesThe aim of the study was to investigate the effects of chronic stimulant abuse on the cortico-striatal limbic circuit. This was examined by relating cortisol levels with grey matter volume in brain structures associated with addiction and stress.AimsWe hypothesised that stimulant-dependent individuals show increased cortisol levels and abnormalities in the corticostriatal- limbic circuit. We further hypothesised relationships between altered grey matter volume and increased cortisol levels in the patients.MethodsTwenty-two stimulant-dependent individuals and 21 healthy volunteers (matched for age and gender) underwent an assessment session and structural MRI brain scan. Cortisol was assessed in saliva and blood plasma. Mood, impulsivity and compulsivity were measured by clinical instruments.ResultsStimulant-dependent individuals showed higher levels of cortisol in both saliva and blood, which were associated with distinct alterations in grey matter volume in fronto-limbic structures. Plasma cortisol was positively correlated with the duration of cocaine use. No relationships were found with current mood, trait-impulsivity and drug-related compulsivity.ConclusionsThe relationships observed between cortisol and fronto-limbic structures may, in part, be explained by HPA axis dysfunction and its downstream effects on brain structures involved in stress modulation in stimulant-dependent individuals.