bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Crystal Structure, Spectral and Thermal Characterization of cis-Diaquabis(1,10-phenanthroline)zinc(II) Diorotate Hydrate, cis-[Zn(H2O)2(phen)2](H2Or)2 · (H2O)2.125
Authors: Yeşilel Okan Zafer , Uçar İbrahim , Bulut Ahmet , Ölmez Halis , Büyükgüngör Orhan 
Published: February 2015

Abstract
Preparation, X-ray crystal structure, thermal behavior, and IR spectroscopic studies of cis-diaquabis(1,10-phenanthroline)zinc(II) diorotate hydrate are described. In the compound [Zn(H2O)2(C12H8N2)2](C5H3N2O4)2·(H2O)2.125 (1), the zinc ion, located on a twofold axis, is coordinated by two aqua ligands together with a pair of bidentate 1,10-phenanthroline (phen) molecules, and exhibits a distorted octahedral coordination. The orotate anions have a single negative charge each. The metal−coordinated water molecules link the orotate ions to the metal complex via O-H· · ·O hydrogen bonds. Also the uncoordinated water molecules are bonded to orotate ions through O-H· · ·O hydrogen bonds. Thus, an extensive network of hydrogen bonds together with π-π, and π-ring interactions stabilize the crystal structure and form an infinitive three dimensional structure. The thermal decomposition pathway of 1 has been investigated by the help of thermal analysis data (TG, DTG and DTA).
Synthesis, Spectral, Thermal and Structural Characterization of the Copper(II) Saccharinato Complex of 2–Aminopyrimidine, [Cu(sac–O)2(ampym–N)2(H2O)2]·2ampym
Authors: Yeşilel Okan Zafer , Ölmez Halis , Paşaoğlu Hümeyra , Kaştaş Gökhan , Büyükgüngör Orhan 
Published: February 2015

Abstract
Bis(2-aminopyrimidine-N)diaquabis(saccharinato-O)copper(II) di(2-aminopyrimidine), [Cu(sac-O)2(ampym-N)2(H2O)2] · 2ampym was synthesized and characterized by means of elemental analysis, IR and UV-vis spectroscopy, magnetic susceptibility, simultaneous TG, DTG, DTA techniques, and X-ray diffraction. The complex crystallizes in the monoclinic space group P21/c [a = 7.4697(5), b = 10.1679(5), c = 22.743(2)Å , β = 92.844(5), Z = 2, R = 0.0275, wR= 0.0757, V = 1725.26(19) Å3]. The copper atom is bonded to two ampym N atoms and two sac O atoms as well as to two water O atoms in trans positions in the geometry of a distorted octahedron. There are also two ampym moieties as solvate molecules in the unit cell. The crystal structure is stabilized by N-H· · ·O, O-H· · ·N and C-H· · ·O type hydrogen bonding interactions. Intermolecular π−π interactions between the phenyl rings of ampym groups and C-H· · ·π interactions also support the packing of the molecules. The thermal decomposition of the complex has been studied.
Improved Synthesis of 2-(4-Propylphenyl)ethanol
Authors: Hashmi A. Stephen K. , Burkert Tobias , Bats Jan W. , Martyniak Aleksandra 
Published: February 2015

Abstract
A new procedure for the synthesis of 2-(4-propylphenyl)ethanol is provided. This new procedure significantly reduces side-products as 1-(4-propylphenyl)ethanol and 2-bromoethanol, which are obtained when using the previously known procedure. Only with the new procedure an efficient purification on the large scale needed for avoided-level-crossing muon-spin resonance experiments was possible.
Structural details of the title compound could be derived from an X-ray structure analysis of a crystalline derivative, the nitrobenzoyl ester.
Synthesis and Characterization of Silver(I) Saccharinate Complexes with Pyrazole and Imidazole Ligands: [Ag(sac)(pz)(H2O)]n and [Ag(sac)(im)] · 2H2O
Authors: Yilmaz Veysel T. , Hamamci Sevim , Büyükgüngör Orhan 
Published: February 2015

Abstract
Two new silver(I) saccharinate (sac) complexes, [Ag(sac)(pz)(H2O)]n (1) and [Ag(sac)(im)]·2H2O (2) (pz = pyrazole and im = imidazole), have been prepared and characterized by elemental analysis, IR spectroscopy, thermal analysis and single crystal X-ray diffraction. Complexes 1 and 2 crystallize in the monoclinic space group P21/c and triclinic space group P1̅, respectively. The sac, pz and im ligands all are N-coordinated. In 1, the [Ag(sac)(pz)] units are bridged by aqua ligands to generate a one-dimensional helical chain, in which the silver(I) ions exhibit a distorted square-planar AgN2O2 coordination geometry. The polymeric chains are connected by N-H· · ·O hydrogen bonds into sheets, which are further linked by aromatic π(pz) · · ·π(sac) stacking interactions into a three-dimensional supramolecular network. Complex 2 consists of individual molecules containing linearly coordinated silver(I) ions with a slightly distorted coordination of AgN2. The molecules interact with each other through hydrogen bonds and π· · ·π interactions to form a three-dimensional supramolecular network.
Synthesis and Structure of 1-Substituted Benzopyrano- [4’,3’-c]benzo[3”,4”-ƒ]-2,8-dioxabicyclo[3.3.1]nonane
Authors: Manolov Ilia , Maichle-Moessmer Caecilia , Niquet Elke 
Published: February 2015

Abstract
The base catalyzed condensation reaction between 4-hydroxycoumarin and 3-acetylcoumarin (3-benzoylcoumarin) in water at reflux led to the formation of 1-methyl (1-phenyl)- benzopyrano[4’,3’-c]-benzo[3”,4”-ƒ ]-2,8-dioxabicyclo[3.3.1]nonane (2a, b) as final products. When 4-hydroxycoumarin and 3-acetylcoumarin reacted in a glacial acetic acid in the presence of potassium acetate the final product was 7-[3-acetyl-2-oxo-3,4-dihydro-2H-[1]benzopyran-4-yl]methyl- 6H,14H,14bH-bis-([1]benzopyrano)[4,3-b:4’,3’-d]pyran-6,14-dione (4). 4-Hydroxycoumarin and 4-(5-bromo-2-hydroxyphenyl)-3-buten-2-one were condensed in water at reflux and 1- methylcoumarino-[4’,3’-c]-bromobenzo[3”,4”-ƒ ]-2,8-dioxabicyclo[3.3.1]nonane was a final product (3).
Synthesis, Semiempirical, Stereoselectivity and Pharmacological Activity of a New Class of Spiro Pyrrolidine and Isoquinoline Derivatives
Authors: Londhe A.V. , Gupta B. , Kohli S. , Pardasani P. , Pardasani R. T. 
Published: February 2015

Abstract
1,3-Dipolar cycloaddition of azomethine ylides derived from acenaphthylene-1,2-dione and 5- methyl-benzo[b]-thiophene-2,3-dione with L-proline, thiazolidine-4-carboxylic acid and 1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid with various electron deficient dipolarophiles leads to the formation of novel spiroheterocycles having two or more chiral centers. Semiempirical studies have been performed to understand the stereochemical course of the reaction. The synthesized cycloadducts have been screened for antimicrobial and toxicological activity.
Structure of the Cocrystal of 2,2’-Diamino-4,4’-bis(1,3-thiazole) and 4,4’-Bipyridine
Authors: Amiri Maryam G. , Ranjbar Zohreh R. , Morsali Ali , Xiao Hong-Ping 
Published: February 2015

Abstract
A new cocrystal based upon 2,2’-diamino-4,4’-bis(1,3-thiazole) and 4,4’-bipyridine has been synthesized and characterized. Self-assembly of this compound in the solid state is likely caused by both hydrogen boding and π-π stacking, and the network contains large vacant voids.
1,1- and 1,2-Allylboration of Alkyn-1-ylsilanes Bearing Si-H Functions. Electron-Deficient Si-H-B Bridges, and Intramolecular Hydrosilylation
Authors: Wrackmeyer Bernd , Tok Oleg L. 
Published: February 2015

Abstract
The reactions of n-hexyn-1-ylsilanes or arylethyn-1-ylsilanes, bearing methyl groups and one (2), two (3) or three hydride functions (4) at the silicon atom, with triallylborane 1 lead primarily to products of 1,1- or 1,2-allylboration. In the alkenes (5, 9, 13) formed by stereoselective 1,1-allylboration, with the silyl and the diallylboryl groups in cis-positions at the C=C bond an electron-deficient Si-H-B bridge is present. The activation of the Si-H bond in these alkenes induces intramolecular hydrosilylation under very mild reaction conditions to give 1,4-silabora-cyclohept-2-enes (7 and 11). The products of 1,2-allylboration (6, 10, 14) are further transformed into 1-boracyclohex-2-enes (8, 12, 15) and 7-borabicyclo[3.3.1]non-2-enes (16, 17) by intramolecular 1,2-allylboration reactions. The proposed structures are based on consistent sets of 1H, 11B, 13C and 29Si NMR data.
Redox Behaviour of Pyrazolyl-Substituted 1,4-Dihydroxyarenes: Formation of the Corresponding Semiquinones, Quinhydrones and Quinones
Authors: Lerner Hans-Wolfram , Margraf Günter , Kretz Tonia , Schiemann Olav , Bats Jan W. , Dürner Gerd , Biani Fabrizia Fabrizi de , Zanello Piero , Boltea Michael , Wagner Matthias 
Published: February 2015

Abstract
Pyrazolyl-substituted 1,4-dihydroxybenzene and 1,4-dihydroxynaphthene derivatives have been synthesized by reaction of 1,4-benzoquinone and 1,4-naphthoquinone, respectively, with pyrazole. Cyclovoltammetric measurements have shown that 1,4-benzoquinone possesses the potential to oxidize 2-(pyrazol-1-yl)- and 2,5-bis(pyrazol-1-yl)-1,4-dihydroxybenzene. The 2,5-bis(pyrazol-1-yl)- 1,4-dihydroxybenzene reacts with air to give quantitatively black insoluble 2,5-bis(pyrazol-1-yl)-1,4- quinhydrone. Black crystals of 2,5-bis(pyrazol-1-yl)-1,4-quinhydrone suitable for X-ray diffraction were grown from methanol at ambient temperature (monoclinic C2/c). The poor yields of pyrazolylsubstituted 1,4-dihydroxybenzene and 1,4-dihydroxynaphthene derivatives can be explained by the formation of insoluble black quinhydrons in the reaction of benzoquinone and naphthoquinone with pyrazole. The dianions of 2-(pyrazol-1-yl)- and 2,5-bis(pyrazol-1-yl)-1,4-dihydroxybenzene react with oxygen to give the corresponding semiquinone anions. 2,5-Bis(pyrazol-1-yl)-1,4-benzoquinone shows two reversible one-electron reduction processes in cyclovoltammetric measurements, whereas pyrazolyl-substituted 1,4-dihdroxybenzene and -naphthene derivatives undergo irreversibile electrontransfer processes.
Dimethylaminomethylene-α-D-xylo-hept-5-ulofuranurononitrile as Building Block in the Synthesis of ‘Reversed’ C-Nucleoside Analogues
Authors: Hashmi Imran Ali , Feist Holger , Michalik Manfred , Reinke Helmut , Peseke Klaus 
Published: February 2015

Abstract
3-O-Benzyl-6-deoxy-1,2-O-isopropylidene-6-(dimethylaminomethylene)-α-D-xylo-hept-5-ulofuranurononitrile (1) was reacted with amidinium salts, S-methylisothiouronium sulfate, and guanidinium chloride, respectively, in the presence of bases to furnish the 4-(3-O-benzyl-1,2-O-isopropylidene- α-D-xylo-tetrofuranos-4-yl)pyrimidine-5-carbonitriles 2 and the 4-(1,2-O-isopropylidene- α-D-glycero-tetr-3-enofuranos-4-yl)pyrimidine-5-carbonitriles 3, respectively. Treatment of 1 with ethyl 5-aminopyrazole-4-carboxylates yielded the ethyl 7-(3-O-benzyl-1,2-O-isopropylidene- α-D-xylo-tetrofuranos-4-yl)-6-cyanopyrazolo[1,5-a]pyrimidine-3-carboxylates 4 and the ethyl 7-amino-6-(3-O-benzyl-1,2-O-isopropylidene-α-D-xylo-pentofuranuronoyl)pyrazolo[1,5-a]pyrimidine- 3-carboxylates 5, respectively. Reaction of 1 with 2-benzimidazolylacetonitrile in the presence of sodium methanolate afforded 1-amino-2-(3-O-benzyl-1,2-O-isopropylidene-α-D-xylo-pentofuranuronoyl) benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile (6) and 1-amino-2-(3-deoxy-1,2-O-isopropylidene- α-D-glycero-pent-3-enofuranuronoyl)benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile (7).
Oxetanes from Photocycloaddition of 2-Aminopropenenitriles to Methyl Phenylglyoxylate and Benzils
Authors: Wolven Christiane van , Döpp Dietrich , Henkel Gerald 
Published: February 2015

Abstract
By irradiation of methyl phenylglyoxylate (1) in benzene solution in presence of equimolar amounts of 2-aminopropenenitriles H2C=C(NR2)CN (3a - e, NR2 = morpholino, 1-pyrrolidinyl, 1-piperidinyl, hexamethyleneimino, heptamethyleneimino) the corresponding 2R∗,3R∗ head-to-head oxetanes 4a - e were obtained in moderate yields (11 - 52%) along with 2 - 28% of rac-dimethyl 2,3- diphenyltartrate (2). In presence of (S)-2-(2-methoxymethylpiperidin-1-yl)propenenitrile ((+)-3g) 1 is transformed into 26% of 2 and 33% of a mixture of diastereomeric oxetanes 4g,4’g in a ratio of 1.4 : 1 which could be improved to 2.5 : 1 by preparative layer chromatography. The absolute configuration of the major diastereomer 4g was unambiguously confirmed by a single crystal X-ray structure determination to be 2R,3R,2’S. Analogous photoadditions to benzil (5a), 4,4’-bis-(trifluoromethyl)benzil (5b) and 4,4’-dichlorobenzil (5c) with (+)-3g and its lower homologue (S)-2-(2-methoxymethylpyrrolidin- 1-yl)propenenitrile ((-)-3f) gave oxetanes only in low yield as detected by 1H NMR. Byproducts arise from competitive symmetrical α-cleavage of 5.
Oxokohlenstoffe und verwandte Verbindungen, 30 [1]. Über die Umsetzung von Quadratsäure mit Pyrazolinonen / Oxocarbons and Related Compounds, 30 [1]. On the Reaction of Squaric Acid with Pyrazolinones
Authors: Schmidt Arthur H. , Schreck Timo , Rötz Ralf , Freytag-Loringhoven Sarah von 
Published: February 2015

Abstract
Heating of squaric acid (1) with the 1-aryl-3-methyl-5-oxo-2,5-dihydro-1H-pyrazoles 3a - j and the 1,3-disubstituted pyrazolinones 7a - d in the molar ratio of 1:2 in a mixture of n-BuOH/toluene afforded the bis(pyrazolyl)-squaraines 4a - j and 8a - d, respectively. Reaction of an excess of 1 with the pyrazolinone 3j yielded 4j and the 3-hydroxy-4-pyrazolyl-cyclobutene-1,2-dione 6 as a byproduct. In contrast to disubstituted pyrazolinones, the trisubstituted pyrazolinones 9a - e reacted with squaric acid (1) to give the hydroxy-oxopyrazolyl-cyclobutenediones 10a - e.
Prefluostatin and New Urauchimycin Derivatives Produced by Streptomycete Isolates
Authors: Yao C. B. Fondja , Schiebel M. , Helmke E. , Anke H. , Laatsch H. 
Published: February 2015

Abstract
Guided by chemical screening, two new members of the antimycin group, urauchimycin C (1b) and D (1a), were isolated from the marine-derived Streptomyces sp. isolate B1751 and from a terrestrial strain AdM21, together with prefluostatin (2), a new natural derivative of isoprekinamycin (4). Their structures were established on the basis of NMR data and by comparison with known compounds. In the agar diffusion test, urauchimycin C (1b) and D (1a) were antibiotically inactive against some bacteria and fungi at a concentration of 25 μg per paper disk, while the isoprekinamycin derivative 2 showed weak cytotoxicity and moderate activity in the agar diffusion test against Bacillus subtilis, Mucor miehei, Escherichia coli and Staphylococcus aureus at concentrations of 20 μg per paper disk.
Aromatization of Hantzsch 1,4-Dihydropyridines with Urea-Hydrogen Peroxide/Maleic Anhydride
Authors: Momeni Ahmad R. , Aliyan Hamid , Mombeini Heidar , Massah Ahmad R. , Naghash Hamid J. 
Published: February 2015

Abstract
A simple method for the oxidative aromatization of Hantzsch 1,4-dihydropyridines to the corresponding pyridines is reported using urea-hydrogen peroxide/maleic anhydride in acetonitrile.
Synthesis, Characterization and Antibacterial Studies of Some 1,2,4-Triazole Derivatives Containing a 6-Chloropyridin-3-yl methyl Moiety
Authors: Holla Bantwala S. , Prasanna Channamata S. , Poojary Boja , Ashok Mithun , Rao Kottapalli S. , Shridhara Kanakamajalu 
Published: February 2015

Abstract
5-(6-Chloropyridin-3-yl methyl)-4-phenyl-1,2,4-triazole-3-thiol (2) and 5-substituted-4-phenyl- 1,2,4-triazole-3-thiols (3) were synthesized. Alkylation and aminomethylation reactions of these triazoles were also carried out. Some of the newly synthesized compounds were screened for their antibacterial activities.
Crystal Structure of NdNiO3 at 123 and 292 K
Authors: Alonso José A. , Demazeau Gérard , Largeteau Alain , Kurowski Daniel , Hoffmann Rolf-Dieter , Pöttgen Rainer 
Published: February 2015

Abstract
Well-shaped, small single crystals of the NdNiO3 perovskite were grown under high oxygen pressure conditions in a belt-type press at 4 GPa. The reaction took place in sealed platinum capsules in the presence of KClO3 as oxidizing agent. It seems that the choice of hydroxides of the involved cations as precursor reagents is crucial for the success of the crystal growth, via water vapor transport reactions. NdNiO3 was investigated by X-ray powder and single crystal diffraction at 123 and 292 K: GdFeO3 type, Pbnm, a = 538.10(7), b = 537.91(7), c = 760.26(10) pm, wR2 = 0.0434, 338 F2 values, and 29 variables at 292 K. The lowtemperature data gave no hint for a monoclinic distortion: Pbnm, a = 537.91(8), b = 538.49(8), c = 760.02(12) pm, wR2=0.0299, 338 F2 values, and 29 variables. At room temperature, the Ni-O distances vary from 193.9 to 194.2 pm, and the O-Ni-O angles cover the range from 89.5 to 90.5°. Similar small distortions are observed for the NiO6 octahedra at 123 K. Due to the strong orthorhombic distortion, the neodymium atoms have only nine oxygen neighbors at Nd-O distances from 236.0 to 295.7 pm.
ζ-Y2[Si2O7]: Ein neuer Strukturtyp in der Yttrialit-Reihe / ζ -Y2[Si2O7]: A New Structure Type within the Yttrialite Series
Authors: Hartenbach Ingo , Meier Steffen F. , Schleid Thomas 
Published: February 2015

Abstract
During attempts of preparing yttrium oxotellurates(IV) using Y2O3 and TeO2 in YCl3 fluxes, the occasional reaction of these educts with the walls of the evacuated silica ampoules led to colourless, lath-shaped single crystals of Y2[Si2O7] in the new ζ -type structure as a minor by-product which was investigated by X-ray diffraction. The title compound crystallizes monoclinically in the space group P21/m (a = 503.59(5), b = 806.47(8), c = 732.65(7) pm, β = 108.633(6)°) with two formula units per unit cell. The crystallographically unique Y3+ cation is coordinated by seven oxygen atoms (d(Y-O = 221 - 248 pm) arranged in the shape of a slightly distorted monocapped octahedron. The isolated oxodisilicate units [Si2O7]6− consist of two Si4+ cations and seven O2− anions of which five are crystallographically independent. These pyroanions (d(Si-O) = 161 - 168 pm, ∢ (O-Si-O) = 91 - 117°, ∢ (Si-O-Si) = 156°) exhibit an almost perfectly eclipsed conformation built of a horseshoeshaped backbone with the two silicon and three of the oxygen atoms situated on the mirror planes of the unit cell. The remaining four oxide anions complete this [Si2O7]6− entity of two vertex-sharing [SiO4]4− tetrahedra as terminal ligands for silicon. Assembled in planar layers parallel to (−1 0 1), the [Si2O7]6− anions are packed with their wide basal faces of the tetrahedra pointing towards the small waist of the adjacent units and vice versa. The yttrium cations reside between these layers in order to interconnect them three-dimensionally.
Synthesis, Spectral and Thermal Studies, and Crystal Structure of cis-Bis(imidazole)bis(picolinato)copper(II) Dihydrate [Cu(pic)2(im)2] ·2H2O
Authors: Heren Zerrin , Keser Cem , Ersanlı C. Cüneyt , Yeşilel O. Zafer , Büyükgüngör Orhan 
Published: February 2015

Abstract
The mixed-ligand picolinato (pic) complex of Cu(II) with imidazole (im), [Cu(pic)2(im)2] ・2H2O, was synthesized and characterized by elemental analysis, magnetic susceptibility, spectral methods (UV/vis and FT-IR), simultaneous TG, DTA techniques, mass spectroscopy, and X-ray diffraction. The complex crystallizes in the monoclinic space group Cc with the following unit cell parameters: a = 16.381(1), b = 9.556(1), c = 5.177(1) Å , β = 119.074(5)°, Z = 4. In the octahedral complex, the picolinato ligands are coordinated to the copper(II) ion as bidentate N,O-donors forming chelate rings. The imidazole ligands are N-coordinated at cis positions. The thermal decomposition pathway of the complex has been studied by the help of thermal analyses data (TG and DTA) and of the mass spectroscopic fragmentation pattern. The volatile products observed in the thermal decomposition process were also observed in the mass spectrometer ionisation process, except for the molecular peak, and it was concluded that the ionisation and thermal decomposition pathways of the complex resemble each other.
Dimethyl Sulfoxide Containing Platinum(II) and Palladium(II) Chelate Complexes of Glyoxylic and Pyruvic Acid Thiosemicarbazones. A New Class of Cytotoxic Metal Complexes
Authors: Dodoff Nicolay I. , Kovala-Demertzi Dimitra , Kubiak Maria , Kuduk-Jaworska Janina , Kochel Andrzej , Gorneva Galina A. 
Published: February 2015

Abstract
The complexes [Pt(DMSO)(GT)]·DMSO (1), [Pt(DMSO)(PT)]· 1/2 DMSO (2) and [Pd(DMSO)- (PT)] (3), where DMSO = dimethyl sulfoxide, H2GT = glyoxylic acid thiosemicarbazone and H2PT = pyruvic acid thiosemicarbazone, have been synthesized and characterized by elemental analysis, molar electric conductivity, IR, electronic and NMR (1H and 13C) spectra. The single crystal X-ray diffraction analysis has revealed for 1 (orthorhombic, Pnma, a = 12.941(3), b = 7.108(2), c = 15.148(3) Å , Z = 4) that the doubly deprotonated thiosemicarbazone molecule is coordinated to Pt(II) via the carboxylato O, azomethine N and thiolato S atoms forming two condensed fivemembered chelate rings. The fourth coordination site of Pt(II) is occupied by the S atom of DMSO. All the atoms of the complex molecule are coplanar except the methyl groups. The O atom of DMSO is in cis-position towards the thiolato-S atom (point group Cs). A system of hydrogen bonds of the type N-H· · ·O links the complex molecules between them and with the lattice DMSO molecules. Similar structures have been deduced for the remaining two complexes on the basis of spectroscopic data. The three complexes and the ligand H2GT exhibit cytotoxic activity against F4N leukemia cells, whereas the ligand H2PT is inactive.
Recurvosides A and B, Antifungal Novel Steroidal Glucosides from Haloxylon recurvum
Authors: Sharif Ahsan , Ahmed Ejaz , Malik Abdul 
Published: February 2015

Abstract
Recurvosides A (1) and B (2), new steroidal glucosides, have been isolated from the ethyl acetate soluble fraction of Haloxylon recurvum and their structures elucidated by spectroscopic techniques including two-dimensional NMR. Both the compounds exhibited potent antifungal activity.
A New Bioactive Steroidal Saponin from Leaves of Furcraea gigantea
Authors: Silva Bernadete P. da , Parente José P. 
Published: February 2015

Abstract
A new bidesmosidic furostanol saponin was isolated from leaves of Furcraea gigantea Vent. Its structure was established as 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β -D-glucopyranosyl-( 1→3)-O-[O-β -D-glucopyranosyl-(1→3)-β -D-glucopyranosyl-(1→2)-O-β -D-glucopyranosyl- (1→4)-β -D-galactopyranosyl)oxy]-(3β ,5α,15α,22α,25R)-26-(β -D-glucopyranosyloxy)-15,22-dihydroxy- furost-12-one. Its structural identification was performed using detailed analyses of 1H and 13C NMR spectra including 2D NMR spectroscopic techniques (DEPT, COSY, HETCOR and COLOC) and chemical conversions. The steroidal saponin showed no haemolytic effects in the in vitro assays and demonstrated inhibition of the capillary permeability activity.
A Novel Route to 4-Aminopyrazoles and Aminopyrazolo[4,3-b]pyridines
Authors: Salaheldin Abdellatif M. , Abdallah Tayseer A. , Radwan Naglaa F. , Hassaneen Hamdi M. 
Published: February 2015

Abstract
3-Oxo-2-arylhydrazononitriles 6 are readily converted into 4-aminopyrazoles 1 via reaction with α-haloketones, chloroacetonitrile and ethyl chloroacetate. The aminopyrazoles are readily converted into aminopyrazolo[4,3-b]pyridines upon treatment with malononitrile. Compounds are readily diazotized to yield unstable diazonium salts that readily cyclized into pyrazolo[4,3-c]pyridazines.
Triterpene Saponins from Calendula arvensis
Authors: Kırmızıbekmez Hasan , Bassarello Carla , Piacente Sonia , Pizza Cosimo , Çalış İhsan 
Published: February 2015

Abstract
From the aerial parts of Calendula arvensis a new triterpene saponin arvensoside C (1) was isolated together with four known triterpene saponins. The aglycon moieties had the oleanane skeleton for all of them. Three known flavonol glycosides, isorhamnetin 3-O-β -D-glucopyranoside, quercetin 3-O-β -D-glucopyranoside and quercetin 3-O-β -D-galactopyranoside were also obtained and characterized. Their structures were elucidated by 1D and 2D NMR experiments including 1D-TOCSY, DQF-COSY, HOHAHA, HSQC and HMBC spectroscopy as well as HRESIMS analysis.