bluuebunny/crossref_metadata_2025_split huggingface dataset:
The socioeconomic impacts of Rift Valley fever: A rapid review
Authors: O’Neill Luke , Gubbins Simon , Reynolds Christian , Limon Georgina , Giorgakoudi Kyriaki 
Published: August 2024

Rift Valley fever (RVF) is a neglected vector-borne disease which is endemic in many countries across Africa and has seen recent geographical expansions into the Arabian Peninsula. RVF can cause severe infections in both animals and humans. RVF infections in livestock can lead to mass fatalities. In humans, the symptoms are nonspecific and can often lead to misdiagnosis. However, a small proportion progresses to haemorrhagic infection with a significantly higher mortality rate. The culmination of this can cause severe socioeconomic impacts.
This review aims to identify the main socioeconomic impacts caused by RVF outbreaks as well as existing knowledge gaps.
Ninety-three academic and grey papers were selected, covering 19 countries and 10 methodological approaches. A variety of socioeconomic impacts were found across all levels of society: Livestock trade disruptions consequently impacted local food security, local and national economies. Most livestock farmers in endemic countries are subsistence farmers and so rely on their livestock for sustenance and income. RVF outbreaks resulted in a variety of socioeconomic impacts, e.g., the inability to pay for school fees. Main barriers to vaccine uptake in communities were lack of access, funds, interest along with other social aspects. The occupational risks for women (and pregnant women) are largely unknown.
To our knowledge, this is the first review on RVF to highlight the clear knowledge gap surrounding the potential gender differences on risks of RVF exposure, as well as differences on occupational health risk in pastoral communities. Further work is required to fill the gaps identified in this review and inform control policies.
Development of a Core Outcome Measure Instrument; "LeishCOM_LCL”, for Localised Cutaneous Leishmaniasis
Authors: Ranasinghe Shalindra , Senarathne Sujai , Somaratne Vijani , Lacey Charles J. N. , Jayakody Surangi , Wickramasinghe Amila , Kahawita Indira , Goto Hiro , Chatterjee Mitali , Lindoso José A. L. , Parkash Vivak , Chaudhuri Surya J. , Wickremasinghe Renu , Das Nilay K. , Kaye Paul M. , Layton Alison M. 
Published: August 2024

Background
Localized cutaneous leishmaniasis (LCL) is a chronic ulcerating disease. A literature review identified inconsistencies in clinical trials. The aims of this study were to reach a consensus on the most important domains to measure when assessing LCL, agree on parameters to measure the domains, and develop a tool representing a Core Outcome Set (COS), for use in clinical assessment of LCL.

Methodology & principal findings
A literature review was conducted to identify any existing COS for LCL embracing agreed Outcome Domains, i.e. what to measure and any Outcome Measurement Instruments (OMIs). As no COS was available, potential outcome domains for assessment of LCL were identified through an international collaborative approach using e-consultations and virtual discussions with expert stakeholders (n = 20) from geographically different LCL endemic countries. Subsequent judgmental validation process included a face-to-face multidisciplinary stakeholders’ meeting adopting the Nominal Group Technique. A final consensual agreement on outcome domains and items required to measure these domains was established. “Clinical Cure” was defined as the ideal overall "General Concept". The five Core Outcome Domains included Signs capturing clinical morphology, diameter, and induration of an index lesion with the aid of a palpability score, Treatment Efficacy assessing percentage change in size of the lesion and re-epithelialization compared to baseline, Treatment Impact which included an investigator and patient visual analogue score, and Clinical Sequelae rating pigment change, atrophic and hypertrophic/keloid scars. It was agreed that two open-ended questions should be included to capture some aspects of Health-Related Quality of Life as a means of capturing a patient-focused approach.

Conclusion
LeishCOM_LCL was generated to reflect a COS for LCL. This captured demographic details, agreed outcome domains and measures to assess these domains. Validation of LeishCOM_LCL will be reported in a separate paper. Development of a Patient Reported Outcome Measure will be considered in the future.
PathEX: Make good choice for whole slide image extraction
Authors: Yang Xinda , Zhang Ranze , Yang Yuan , Zhang Yu , Chen Kai 
Published: August 2024

Background
The tile-based approach has been widely used for slide-level predictions in whole slide image (WSI) analysis. However, the irregular shapes and variable dimensions of tumor regions pose challenges for the process. To address this issue, we proposed PathEX, a framework that integrates intersection over tile (IoT) and background over tile (BoT) algorithms to extract tile images around boundaries of annotated regions while excluding the blank tile images within these regions.

Methods
We developed PathEX, which incorporated IoT and BoT into tile extraction, for training a classification model in CAM (239 WSIs) and PAIP (40 WSIs) datasets. By adjusting the IoT and BoT parameters, we generated eight training sets and corresponding models for each dataset. The performance of PathEX was assessed on the testing set comprising 13,076 tile images from 48 WSIs of CAM dataset and 6,391 tile images from 10 WSIs of PAIP dataset.

Results
PathEX could extract tile images around boundaries of annotated region differently by adjusting the IoT parameter, while exclusion of blank tile images within annotated regions achieved by setting the BoT parameter. As adjusting IoT from 0.1 to 1.0, and 1—BoT from 0.0 to 0.5, we got 8 train sets. Experimentation revealed that set C demonstrates potential as the most optimal candidate. Nevertheless, a combination of IoT values ranging from 0.2 to 0.5 and 1-BoT values ranging from 0.2 to 0.5 also yielded favorable outcomes.

Conclusions
In this study, we proposed PathEX, a framework that integrates IoT and BoT algorithms for tile image extraction at the boundaries of annotated regions while excluding blank tiles within these regions. Researchers can conveniently set the thresholds for IoT and BoT to facilitate tile image extraction in their own studies. The insights gained from this research provide valuable guidance for tile image extraction in digital pathology applications.
Registered report protocol for an e: Health motor skills and physical activity intervention in early childhood education centers- e: Motor skills At Playtime (MAP)
Authors: Palmer Kara K. , Wang Lu 
Published: August 2024

Background
Children have alarmingly low levels of competency in fundamental motor skills (FMS) and high levels of physical inactivity. e:health interventions, interventions delivered electronically, are useful tools for intervention in the home through parents, but less is known about the effects of these interventions in early childhood education centers or settings. Therefore, we created the Motor skills At Playtime (MAP) e:health intervention (e:MAP) to be delivered in an early childhood education setting. The goals of this pilot study on e:MAP are to (1) determine the intervention effects on children’s FMS and physical activity and (2) explore the teachers’ perceptions and ability to facilitate e:MAP.

Methods
This pilot study uses a pretest/posttest randomized cluster control design. We will recruit at least 64 children (3.5–5 years of age) enrolled in a single early childhood education center. Children will be randomly assigned at the level of the classroom to an e:MAP group (n~30) or a control group (n~30). Children in classrooms assigned to e:MAP will complete an 8-week intervention. We will collect measures of child FMS and physical activity, and teacher’s perceptions of the program before (pretest) and after the intervention (posttest). FMS measures include process (Test of Gross Motor Development-3rd Edition) and product-oriented scores. Physical activity will be assessed using a 7-day accelerometer wear protocol. Teachers’ perceptions will be assessed through a brief survey. Lastly, we will collect data on teachers’ ability to facilitate e:MAP through a daily survey.

Potential significance
This study will yield novel insights into the effectiveness and feasibility of a health intervention in an early childhood education setting. Results from this work will expand our knowledge of how to harness e:health modalities, which have the potential to significantly expand the distribution and scalability of FMS interventions.
Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis
Authors: Wang Fanchen , Xiao Jiacong , Li Miao , He Qi , Wang Xintian , Pan Zhaofeng , Li Shaocong , Wang Haibin , Zhou Chi 
Published: August 2024

Background
Picroside II (P-II) is the main bioactive constituent of Picrorhiza Kurroa, a traditional Chinese herb of interest for its proven anti-inflammatory properties. Its beneficial effects have been noted across several physiological systems, including the nervous, circulatory, and digestive, capable of treating a wide range of diseases. Nevertheless, the potential of Picroside II to treat osteoarthritis (OA) and the mechanisms behind its efficacy remain largely unexplored.

Aim
This study aims to evaluate the efficacy of Picroside II in the treatment of osteoarthritis and its potential molecular mechanisms.

Methods
In vitro, we induced cellular inflammation in chondrocytes with lipopolysaccharide (LPS) and subsequently treated with Picroside II to assess protective effect on chondrocyte. We employed the Cell Counting Kit-8 (CCK-8) assay to assess the impact of Picroside II on cell viability and select the optimal Picroside II concentration for subsequent experiments. We explored the effect of Picroside II on chondrocyte pyroptosis and its underlying molecular mechanisms by qRT-PCR, Western blot (WB) and immunofluorescence. In vivo, we established the destabilization of the medial meniscus surgery to create an OA mouse model. The therapeutic effects of Picroside II were then assessed through Micro-CT scanning, Hematoxylin-eosin (H&E) staining, Safranin O-Fast Green (S&F) staining, immunohistochemistry and immunofluorescence.

Results
In in vitro studies, toluidine blue and CCK-8 results showed that a certain concentration of Picroside II had a restorative effect on the viability of chondrocytes inhibited by LPS. Picroside II notably suppressed the expression levels of caspase-1, IL-18, and IL-1β, which consequently led to the reduction of pyroptosis. Moreover, Picroside II was shown to decrease NLRP3 inflammasome activation, via the MAPK/NF-κB signaling pathway. In vivo studies have shown that Picroside II can effectively reduce subchondral bone destruction and osteophyte formation in the knee joint of mice after DMM surgery.

Conclusions
Our research suggests that Picroside II can inhibit chondrocyte pyroptosis and ameliorate osteoarthritis progression by modulating the MAPK/NF-κB signaling pathway.
Investigation of breast cancer molecular subtype in a multi-ethnic population using MRI
Authors: Ab Mumin Nazimah , Ramli Hamid Marlina Tanty , Wong Jeannie Hsiu Ding , Chiew Seow-Fan , Rahmat Kartini , Ng Kwan Hoong 
Published: August 2024

Objectives
Accurate subtyping of breast cancer is crucial for its diagnosis, management, and prognostication. This study aimed to determine the association of magnetic resonance imaging (MRI) breast features with the molecular subtype and aggressiveness of breast cancer in a multi-ethnic population.

Methods
Treatment-naive patients with invasive breast carcinoma were included in this retrospective study. Breast MRI features were recorded based on the American College of Radiology-Breast Imaging Reporting and Data System (ACR-BIRADS) criteria, with tumour size, and apparent diffusion coefficient value (ADC). The statistical association was tested with Pearson Chi-Square Test of Independence for categorical data or the Kruskal-Wallis/ Mann Whitney U test for numerical data between the MRI features and molecular subtype, receptor status, tumour grade, lymphovascular infiltration (LVI) and axillary lymph node (ALN). Multinomial logistic regression was used to test the predictive likelihood of the significant features. The breast cancer subtypes were determined via immunohistochemistry (IHC) and dual-color dual-hapten in-situ hybridization (D-DISH). The expression statuses of ER, PR, and HER-2, LVI, and ALN were obtained from the histopathology report. The ER / PR / HER-2 was evaluated according to the American Society of Clinical Oncology / College of American Pathologists.

Results
The study included 194 patients; 41.8% (n = 81) Chinese, 40.7% (n = 79) Malay, and 17.5% (n = 34) Indian, involving 71.6%(n = 139) luminal-like, 12.9%(n = 25) HER-2 enriched, and 15.5%(n = 30) Triple-negative breast cancer (TNBC). TNBC was associated with rim enhancement (p = 0.002) and peritumoral oedema (p = 0.004). HER-2 enriched tumour was associated with larger tumour size (p = 0.041). Luminal-like cancer was associated with irregular shape (p = 0.005) with circumscribed margin (p = 0.003). Other associations were ER-negative tumour with circumscribed margin (p = 0.002) and PR-negative with round shape (p = 0.001). Tumour sizes were larger in ER-negative (p = 0.044) and PR-negative (p = 0.022). Rim enhancement was significantly associated with higher grade (p = 0.001), and moderate peritumoral oedema with positive axillary lymph node (p = 0.002).

Conclusion
Certain MRI features can be applied to differentiate breast cancer molecular subtypes, receptor status and aggressiveness, even in a multi-ethnic population.
Confluências entre a Análise Discursiva Pecheutiana e a Linguística Funcional Centrada no Uso
Authors: Scaldelai Salles Ana Ligia 
Published: August 2024

Este artigo se propõe a discutir conceitos basilares e específicos de duas subáreas linguísticas, a Análise do Discurso Pecheutiana e a Linguística Funcional Centrada no Uso, com o intuito de elucidar confluências entre as abordagens. A justificativa se pauta na importância de se discutir como a intersecção entre as duas correntes teóricas acontece e como esse diálogo pode contribuir para a descrição de fatos linguísticos. A discussão se concentra na análise de conceitos teóricos no campo da Análise do Discurso, como noção de língua(gem), sujeito, sentido, discurso, ideologia, história e esquecimento mobilizados por autores como Orlandi (2012 [1999]; 2002) e Pêcheux (1990; 1995 [1975]), e como os conceitos de língua(gem), sujeito/falante, sentido, conhecimento linguístico, processos cognitivos e construção podem ser compreendidos no âmbito da Linguística Funcional Centrada no Uso, a partir de Bybee (2016 [2010]) e Traugott e Trousdale (2021 [2013]). Ademais, tais conceitos serão aplicados ao analisar ocorrências de três construções intensificadoras, a saber pra caralho, morri de e pra burro, para fins de tateamento teórico-analítico com o propósito de atestar a contribuição do diálogo das subáreas. Assim, através da presente investigação, constata-se que, apesar de as bases epistemológicas apresentarem conceitos específicos, alguns diálogos são possíveis, já que ambas valorizam a análise de textos reais e a língua em uso.
Addressing Street Children, Vagrants, and Beggars through the Role of Community Social Workers in Yogyakarta
Authors: Niswatun Hasanah  , Karimah Fatha 
Published: August 2024

This study seeks to address the growing social issues in society, particularly the rise in street children, homelessness, and begging. These issues require in-depth exploration to develop effective solutions. A critical group involved in tackling these challenges is the social volunteers, known as Community Social Workers (PSM). The research aims to examine the role of Community Social Workers in addressing these problems in Yogyakarta City. Using a qualitative descriptive approach, the study analyzes the role of PSM, guided by the framework provided in Ministerial Regulation No. 10 of 2019. It highlights that the efforts of PSM to address the needs of street children, homeless individuals, and beggars are not carried out in isolation but require collaboration with government social institutions in Yogyakarta. The findings demonstrate that the role of PSM in these efforts is a reflection of their empathy, commitment, and dedication to the well-being of the Yogyakarta community.
Keywords: Street Children, Homeless, beggars, Community Social Workers

Penelitian ini berusaha untuk mengatasi masalah sosial yang berkembang di masyarakat, terutama meningkatnya jumlah anak jalanan, tunawisma, dan pengemis. Isu-isu ini membutuhkan eksplorasi mendalam untuk mengembangkan solusi yang efektif. Salah satu kelompok penting yang terlibat dalam mengatasi tantangan-tantangan ini adalah relawan sosial, yang dikenal sebagai Pekerja Sosial Masyarakat (PSM). Penelitian ini bertujuan untuk melihat peran Pekerja Sosial Masyarakat dalam mengatasi masalah-masalah tersebut di Kota Yogyakarta. Dengan menggunakan pendekatan deskriptif kualitatif, penelitian ini menganalisis peran PSM dengan berpedoman pada kerangka kerja yang diatur dalam Peraturan Menteri Sosial No. 10 Tahun 2019. Studi ini menyoroti bahwa upaya PSM untuk memenuhi kebutuhan anak jalanan, gelandangan, dan pengemis tidak dilakukan sendiri-sendiri, tetapi membutuhkan kolaborasi dengan lembaga sosial pemerintah di Yogyakarta. Temuan ini menunjukkan bahwa peran PSM dalam upaya ini merupakan cerminan dari empati, komitmen, dan dedikasi mereka terhadap kesejahteraan masyarakat Yogyakarta.
Kata kunci: Anak Jalanan, Tunawisma, Pengemis, Pekerja Sosial Masyarakat
ICT enabled Information Services Using Web 2.0 in Public Libraries of Tamil Nadu
Authors: K.S. Akshaya Kumar , Walia Paramjeet K. 
Published: August 2024

Web 2.0 technologies have a great deal to offer while providing information services and can be used as a platform to increase the discoverability of digital collections, engage library patrons in library activities and to create online services that promote collaboration, cooperation, communication, and information sharing among public libraries at various levels in a country. Present study focuses on ICT enabled information services provided by Connemara Public Library and district central public libraries in Tamil Nadu, India. Study also try to identify the extent to which Web2.0 tools are used in public libraries to provide information services. Findings of the study show that Connemara Public Library and district central libraries in Tamil Nadu are providing ICT enabled information services but only a minority of these libraries are using Web 2.0 tools for the same. Analysis shows that district central public libraries are using Web 2.0 to provide only very basic information to the users. Librarians are not exploiting the full potential of Web 2.0 tools in providing information services.This paper will be helpful for library professionals working in public library system to implement ICT enabled information services in general and Web 2.0 in particular.
Studi Kandungan Dan Sebaran Bahan Organik Di Perairan Kota Pekalongan
Authors: Ningrum Riska Widyah , Zainuri Muhammad , Wulandari Sri Yulina 
Published: August 2024

Perairan pantai Kota Pekalongan mengalami tekanan pembuangan limbah akibat sejumlah aktifitas industri seperti batik, perikanan, UMKM dan lain-lain yang menggunakan sungai Banger sebagai tempat pembuangan limbah. Kandungan bahan organik dari limbah akan menggangu kondisi perairan. Penelitian ini bertujuan untuk mengetahui kandungan dan distribusi bahan organik di perairan Muara Sungai Banger, Kota Pekalongan serta faktor yang mempengaruhi pola distribusinya. Penelitian dilaksanakan dengan pendekatan kuantitatif dan dilaksanakan pada 19 Juni 2022. Data sampel air untuk bahan organik di ambil dan analisis dilakuan di Laboratorium Balai Besar Teknologi Pencegahan Pencemaran Industri (BBTPPI) Semarang. Analisis statistik koefisien korelasi diterapkan untuk mengetahui keterkaitan data lapangan dan peramalan untuk time series. Hasil penelitian menunjukkan bahwa kandungan Total Organic Matter (TOM) di perairan Muara Sungai Banger berkisar antara 3,963 – 7,086 mg/l dan kandungan Biological Oxygen Demand (BOD) di perairan Muara Sungai Banger berkisar antara 2,632 – 4,888 mg/l. Pola persebaran bahan organik di perairan Muara Sungai Banger memiliki kandungan yang lebih tinggi di wilayah pesisir dan berkurang menuju laut lepas. Pengaruh arus terhadap sebaran bahan organik di perairan Muara Sungai Banger menunjukkan korelasi pearson 0.788 yang mengindikasikan arus mempunyai pengaruh yang besar terhadap persebaran bahan organik di perairan.
Glokalisierte Bildungswelten
Authors: Scholz Stefan , Winkler Kathrin 
Published: August 2024

Zusammenfassung
Globale Konflikte bestimmen trotz ihrer Entfernung unseren Alltag mit und wirken auch in den Religionsunterricht hinein. Dieser Beitrag versucht zu skizzieren, was eine postkoloniale Kulturhermeneutik für die Bearbeitung globaler Konflikte im Religionsunterricht leisten kann. Im Vordergrund stehen nicht Lösungen für diese Konflikte vor Ort, sondern differenzierende Klärungen mit dem Ziel, hier bei uns Lernende mit unterschiedlichen biografischen Bezügen zu den Konflikten zu befähigen, sprach- und urteilsfähig zu werden und miteinander im Dialog zu bleiben. Fallbeispiele und eine qualitative Vignette geben in diesem Zusammenhang exemplarische Einblicke in die impliziten Wahrnehmungs- und Beurteilungsmuster von Schülerinnen und Schülern.
Seeking Abraham’s God after October 7th: From Radical Antisemitism to Relational Dialogue
Authors: Alexander Hanan 
Published: August 2024

Zusammenfassung
In diesem Beitrag argumentiere ich, dass das grausame Massaker durch islamische Terroristen der Hamas an unschuldigen israelischen Zivilisten am 7. Oktober 2023 eine Schändung und nicht eine Heiligung des Gottes Abrahams war. Es sollte von allen Menschen guten Willens bedingungslos verurteilt werden. Traurigerweise haben die Gräueltaten der Hamas als eine Form des Widerstands gegen Unterdrückung durch eine unheilige Allianz mit einer neuen Form des intellektuellen Antisemitismus, die in einer bestimmten Auffassung der kritisch-progressivistischen Position zu finden ist, wissenschaftliche Achtung gewonnen. Diese Sichtweise geht von einer stark vereinfachten Dichotomie zwischen Opfern und Tätern aus, in der die Palästinenser fälschlicherweise als Zielscheibe der jüdisch-israelischen Kolonialherrschaft angesehen werden. Ein konstruktiver Dialog zwischen Israelis und Palästinensern lässt sich jedoch durch eine Pädagogik der Differenz erreichen, die intelligente Interpretationen der israelischen und palästinensischen Narrative miteinander verbindet. Nur in der Beziehung, nicht im Radikalismus, können können wir den göttlichen Funken, der in jeder menschlichen Seele steckt, erkennen und wirklich den Gott finden, der zuerst zu Abraham sprach.