bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic variations in TERT‐CLPTM1L locus are associated with risk of lung cancer in chinese population
Authors: Zhong Rong , Liu Li , Zou Li , Zhu Yaowu , Chen Wei , Zhu Beibei , Shen Na , Rui Rui , Long Lu , Ke Juntao , Lu Xuzai , Zhang Ti , Zhang Yu , Wang Zhenling , Liu Lifeng , Sun Yu , Cheng Liming , Miao Xiaoping 
Published: June 2013

AbstractRecent genome‐wide association studies (GWAS) have reported multiple genetic variations at 5p15.33 (TERT‐CLPTM1L) associated with risk of lung cancer. However, most of the associated variations identified by GWAS thus far are unlikely to be the actual causal variants, but may be mostly marker‐single nucleotide polymorphisms tagging functional variations that influence gene expression. This study aimed to explore the function‐validated and potentially functional variations in TERT‐CLPTM1L locus conferring susceptibility to lung cancer. A case–control study including 502 cases and 502 controls in Chinese Han population was firstly conducted. Bioinformatic approaches are applied to prioritize genetic variations based on their potential functionality. In the logistic regression analysis, TERT‐rs2853669, rs2736108, and CLPTM1L‐rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22–1.75; OR = 1.22, 95% CI = 1.00–1.49 and OR = 1.74, 95% CI = 1.35–2.23 under additive model, respectively). The significant associations were observed in non‐small‐cell lung cancer but not‐in‐small‐cell lung cancer, and more prominent in adenocarcinoma. Haplotype analysis presented a significant allele‐dose effect of haplotypes in increasing risk of lung cancer (P for trend = 1.894 × 10−6). Moreover, significant multiplicative interactions were observed between smoking and these three polymorphisms of TERT‐rs2853669, rs2736108, and CLPTM1L‐rs31490, even after bonferroni correction for multiple comparisons (Pinteraction = 1.316 × 10−9, 3.912 × 10−4, and 2.483 × 10−5, respectively). These findings indicated that the function‐validated and potentially functional variations in TERT‐CLPTM1L locus, modified by smoking, may play a substantial role in the susceptibility to lung cancer. © 2013 Wiley Periodicals, Inc.
Promoter hypermethylation along with LOH, but not mutation, contributes to inactivation of DLC‐1 in nasopharyngeal carcinoma
Authors: Feng Xiangling , Ren Caiping , Zhou Wen , Liu Weidong , Zeng Liang , Li Guifei , Wang Lei , Li Min , Zhu Bin , Yao Kaitai , Jiang Xingjun 
Published: June 2013

AbstractPrevious studies have shown that promoter hypermethylation plays a key role in DLC‐1 inactivation in nasopharyngeal carcinoma (NPC). However, DLC‐1 mutation in NPC has not been reported, and there remain some discrepancies in methods and results between different groups. Here, we examined the mRNA and protein expression of DLC‐1 in chronic nasopharyngitis (CN) and NPC tissues by reverse transcription‐polymerase chain reaction/qPCR and immunohistochemistry, respectively. DLC‐1 mRNA was undetectable in all the seven widely used NPC cell lines and absent or significantly down‐regulated in 70% of NPC tissues. DLC‐1 protein level was reduced in 74.3% of NPCs when compared with CN tissues, and significantly lower in NPC samples at advanced clinical stages than that at early stages. Then, we purified the same batch of specimens by microdissection and analyzed the possible mechanisms of DLC‐1 downregulation with mutation and allelic loss analysis, methylation‐specific PCR and bisulfite genomic sequencing. Only one mutation was detected at codon 693 of exon 8 in 3.3% of NPCs and five single nucleotide polymorphisms (SNPs) were identified. Loss of DLC‐1 was detected in 23.3% of NPC tissues. The 100% of NPC cell lines, 80% of primary NPC and 22.2% of CN tissues showed methylation in DLC‐1 promoter, while DLC‐1 expression was recovered in seven NPC cell lines after 5‐aza‐dC treatment. Patched methylation assay confirmed that promoter methylation could repress DLC‐1 expression. This report demonstrates that DLC‐1 is negatively associated with NPC carcinogenesis, and promoter hypermethylation along with loss of heterozygosity, but not mutation, contributes to inactivation of DLC‐1 in NPC. © 2013 Wiley Periodicals, Inc.
Transparente Energiebilanz im Steinkohlenbergbau
Authors: Schmidt Carsten , Traxler Rudolf 
Published: June 2013

AbstractWo wird wie viel Energie benötigt? Auf diese Frage wissen viele Industrieunternehmen keine Antwort. Allerdings schwindet dieses Manko immer mehr, denn die ISO 50001 verleiht der Forderung Nachdruck, den Energieverbrauch nachhaltig zu reduzieren. So haben sich die Betreiber des Steinkohlenbergwerks Auguste Victoria zu einem Pilotprojekt entschlossen, ein umfassendes Energiedaten‐Managementsystem für den Untertagebereich zu installieren. Die Auswertung der Energiedaten bildet die Grundlage für Optimierungen und Energiesparmaßnahmen.
Stand der Bohrtechnik im konventionellen Streckenvortrieb im Flözhorizont Zollverein 6 auf dem Bergwerk Auguste Victoria
Authors: Roßbach Stefan , Andrzejewski Michael , Gastberg Ingolf 
Published: June 2013

AbstractDie zukünftigen Abbau‐ und Vorleistungsaktivitäten auf dem Bergwerk Auguste Victoria konzentrieren sich hauptsächlich im Niveau des Flözhorizonts Zollverein 6 [Einheitsbezeichnung EB Zv. 7/8]. Das Erreichen einer Teufenlage von rund 1.400 m in Verbindung mit schwierigen geologischen Rahmenbedingungen stellt besondere Anforderungen an die Planung, Technik, Organisation und Sicherheit beim Streckenvortrieb, sodass entsprechende Anpassungen in der Vortriebstechnik erforderlich wurden.Im Rahmen des vorliegenden Beitrags werden die aus den geologischen Bedingungen resultierenden verfahrenstypischen Besonderheiten beim konventionellen Streckenvortrieb im Flözniveau Zollverein 6 dargestellt.
The mERG1a channel modulates skeletal muscle MuRF1, but not MAFbx, expression
Authors: Pond Amber L. , Nedele Carrie , Wang Wen‐Horng , Wang Xun , Walther Claire , Jaeger Christine , Bradley Kevin S. , Du Huahua , Fujita Naoya , Hockerman Gregory H. , Hannon Kevin M. 
Published: June 2013

ABSTRACTIntroduction: We investigated the mechanism by which the MERG1a K+ channel increases ubiquitin proteasome proteolysis (UPP). Methods: Hindlimb suspension and electro‐transfer of Merg1a cDNA into mouse gastrocnemius muscles induced atrophy. Results: Atrophic gastrocnemius muscles of hindlimb‐suspended mice express Merg1a, Murf1, and Mafbx genes. Electrotransfer of Merg1a significantly decreases muscle fiber size (12.6%) and increases UPP E3 ligase Murf1 mRNA (2.1‐fold) and protein (23.7%), but does not affect Mafbx E3 ligase expression. Neither Merg1a‐induced decreased fiber size nor Merg1a‐induced increased Murf1 expression is curtailed significantly by coexpression of inactive HR‐Foxo3a, a gene encoding a transcription factor known to induce Mafbx expression. Conclusions: The MERG1a K+ channel significantly increases expression of Murf1, but not Mafbx. We explored this expression pattern by expressing inactive Foxo3a and showing that it is not involved in MERG1a‐mediated expression of Murf1. These findings suggest that MERG1a may not modulate Murf1 expression through the AKT/FOXO pathway. Muscle Nerve 49:378–388, 2014
Incorporation of Bulky and Cationic Cyclam‐Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity
Authors: Yu Mingfeng , Lim Ngee H. , Ellis Samantha , Nagase Hideaki , Triccas James A. , Rutledge Peter J. , Todd Matthew H. 
Published: June 2013

AbstractThe synthesis and matrix metalloproteinase (MMP) inhibitory activity of a cyclam–marimastat conjugate and its metal complexes are described. The conjugate, synthesized with a copper(I)‐catalyzed Huisgen 1,3‐dipolar cycloaddition (“click” reaction), contains two zinc‐binding groups (ZBGs). The metal complexation behavior with copper(II) and zinc(II) was investigated using UV/Vis spectrophotometry and 1H NMR spectroscopy, respectively, demonstrating that the first equivalent of the metal ion was chelated by the cyclam‐triazole moiety rather than the hydroxamic acid site. Thus, the corresponding mononuclear metal–cyclam complexes were successfully prepared with one equivalent of the metal salt. Both the cyclam–marimastat conjugate and its metal complexes exhibited slightly reduced potency against MMP‐1, but essentially identical inhibitory activity against MMP‐3. The conjugate and its metal complexes displayed little or no cytotoxicity, further supporting their potential suitability for imaging MMP localization and activity. To the best of our knowledge, this is the first report that describes the incorporation of metal complexes into an MMP inhibitor without influencing the preexisting ZBG, and the first report of the evaluation of structures containing more than one ZBG as MMP inhibitors.
Viral irony: using irony to spread the questioning of questionable consumption
Authors: Pehlivan Ekin , Berthon Pierre , Berthon Jean‐Paul , Cross Ian 
Published: June 2013

There is iron in irony (Ewart, G. 1980. Selected Poems 1933–1988. New Directions Books: New York, NY).Acentral concern of public affairs is the notion of social justice and the scrutinizing of truth claims in public discourse where the power of social actors is asymmetrical. The mechanisms of rejection of truth claims tend to fall into two camps: direct and indirect. The direct method is simply a public rebuff, whereas the indirect method is to employ a rhetorical device such as irony so that citizens question the claim for themselves and, as importantly, pass the message onto others. It is on this latter mechanism that this paper focuses using the case study of the coal industry's truth claim of ‘clean coal’. Our paper is set out as follows. First, we explore how irony can been used to question the ‘green’ or environmentally friendly claims of powerful organizations. Second, we review the theory of ironic communication and use it to deconstruct the video ‘Coal McClean’. Third, we explore how irony can help a subversive message spread through social networks, or to go ‘viral,’ in ways a direct message cannot. We conclude with a reflection on the research opportunities that the notion of viral irony provides in public affairs. Copyright © 2013 John Wiley & Sons, Ltd.
Efficient synthesis of β‐(1,6)‐linked oligosaccharides through microwave‐assisted glycosylation
Authors: Li Lingyao , Franckowiak Emily A. , Xu Yi , McClain Evan , Du Wenjun 
Published: June 2013

ABSTRACTA microwave‐assisted glycosylation method was developed for efficient synthesis of oligosaccharides. Di‐functional AB monomers, 2,3,4‐tri‐O‐acetyl‐α‐d‐galactopyranosyl bromide (3a) and 2,3,4‐tri‐O‐acetyl‐α‐d‐glucopyranosyl bromide (3b) were designed and synthesized as weakly reactive monomers to avoid unwanted glycosylation or degradation during preparation and storage. The glycosylations of these monomers gave low conversions and low molecular weight oligosaccharides at rt, reflux, and under low microwave energy irradiation. However, the glycosylation became very effective when high microwave energy was applied, giving 100% conversion and producing oligosaccharides with Mn = 4.76 kDa for 3a and Mn = 4.05 kDa for 3b. The acetylated oligosaccharides were further subjected to deprotection for structural analysis, which indicated the oligosaccharides contain predominantly linear β‐(1,6)‐glycosyl linkages. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3693–3699
Intramolecular cyclization assistance for fast degradation of ornithine‐based poly(ester amide)s
Authors: de Gracia Lux Caroline , Olejniczak Jason , Fomina Nadezda , Viger Mathieu L. , Almutairi Adah 
Published: June 2013

ABSTRACTInspired by the spontaneous cyclization of ornithine in peptides, polyesters containing protected ornithine (Orn) side chains along the backbone were synthesized and shown to degrade rapidly upon deprotection through intramolecular cyclization. A new ornithine‐based poly(ester amide) PEA 1 and a lysine‐based control PEA 2, both bearing the light‐sensitive protecting group o‐nitrobenzyl alcohol (ONB), were synthesized. Tert‐butyl carbamate (Boc)‐protected versions 1‐Boc and 2‐Boc were also synthesized for proof of concept. GPC confirmed that 1‐Boc degrades over 40 times faster than 2‐Boc following deprotection into the designed intramolecular cyclization products. Finally, TEM visualization of particles made from 1 encapsulating iron oxide nanoparticles reveals complete disruption of nanoparticles and release of payload within a day upon UV irradiation. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3783–3790
Interplay of I‐TASSER and QUARK for template‐based and ab initio protein structure prediction in CASP10
Authors: Zhang Yang 
Published: June 2013

ABSTRACTWe develop and test a new pipeline in CASP10 to predict protein structures based on an interplay of I‐TASSER and QUARK for both free‐modeling (FM) and template‐based modeling (TBM) targets. The most noteworthy observation is that sorting through the threading template pool using the QUARK‐based ab initio models as probes allows the detection of distant‐homology templates which might be ignored by the traditional sequence profile‐based threading alignment algorithms. Further template assembly refinement by I‐TASSER resulted in successful folding of two medium‐sized FM targets with >150 residues. For TBM, the multiple threading alignments from LOMETS are, for the first time, incorporated into the ab initio QUARK simulations, which were further refined by I‐TASSER assembly refinement. Compared with the traditional threading assembly refinement procedures, the inclusion of the threading‐constrained ab initio folding models can consistently improve the quality of the full‐length models as assessed by the GDT‐HA and hydrogen‐bonding scores. Despite the success, significant challenges still exist in domain boundary prediction and consistent folding of medium‐size proteins (especially beta‐proteins) for nonhomologous targets. Further developments of sensitive fold‐recognition and ab initio folding methods are critical for solving these problems. Proteins 2014; 82(Suppl 2):175–187. © 2013 Wiley Periodicals, Inc.
Impact of subgrid‐scale vertical turbulent mixing on eyewall asymmetric structures and mesovortices of hurricanes
Authors: Zhu Ping , Menelaou Konstantinos , Zhu Zhenduo 
Published: June 2013

AbstractIn this study, the multiple nested state‐of‐the‐art Weather Research and Forecasting (WRF) model is used to investigate the impact of the subgrid‐scale (SGS) vertical turbulent mixing parametrization on hurricane eyewall asymmetric structures and the formation of eyewall mesovortices. Hurricane Isabel (2003) was simulated by a series of numerical experiments with different SGS vertical turbulent mixing parametrizations including the Yonsei University, Mellor–Yamada–Janjic, Mellor–Yamada–Nakanishi–Niino 2.5 level and Mellor–Yamada–Nakanishi–Niino 3 level schemes. The simulations show that the vertical turbulent mixing scheme not only substantially affects the SGS vertical transport of heat and moisture but also has an important bearing on the storm axisymmetric structure, eyewall mesovortices and other resolved asymmetric features in the vicinity of the hurricane eyewall. The analyses show that the vertical turbulent mixing processes provide a mechanism to affect the barotropic instability for generation of eyewall mesovortices through changing the vortex basic state potential vorticity (PV) field and generating eyewall disturbances with different frequencies. Our numerical experiments show for given external conditions that the magnitude and vertical distribution of the eddy exchange coefficients are the key factors that regulate the characteristics of eyewall disturbances. Such a modulation of eyewall structure by the eddy exchange coefficients is realized through the complicated interaction among SGS vertical turbulent mixing, mesoscale structures, diabatic heating and barotropic instability.
Attribution of strong winds to a cold conveyor belt and sting jet
Authors: Smart D. J. , Browning K. A. 
Published: June 2013

AbstractA high‐resolution version of the WRF (Weather Research and Forecasting) model has been used to study the ﬁne structure of a cloud head and its associated cold conveyor belt jet (CJ) and sting jet (SJ) in an intense extratropical cyclone that produced damaging surface winds in northern Ireland and central Scotland on 3 January 2012. The model was run with many diﬀerent initialisation times and physical parametrisations, and a run was selected that veriﬁed well against a variety of observations. New methods have been devised to visualise the 3D structure of the CJ and SJ and to attribute strong surface winds to one or other of them, and the validity of regarding the SJ as a semi‐Lagrangian feature has been assessed. The model suggests that, whereas the CJ remained mainly below the 850 hPa level as it circulated around the bent‐back front, the SJ consisted of a stream or streams of air within the bent‐back frontal zone that ﬁrst ascended from close to the surface into the middle and upper‐level parts of the cloud head before descending from evaporating cloud ﬁlaments at the tip of the cloud head and reaching the top of the boundary layer slightly ahead of the CJ. The simulations did not support the idea that either the evaporation or conditional symmetric instability (CSI) played a major role in the development of these jets. The strong gusts (up to 47 m s−1) which were recorded on the north coast of Ireland appear to have been due mainly to the CJ, which by then was undercutting the SJ. The SJ was responsible for stronger surface winds than the CJ several hours earlier during the initial stage of frontal fracture, but only for a limited period.
Interaction of North Atlantic baroclinic wave packets and the Mediterranean storm track
Authors: Ahmadi‐Givi F. , Nasr‐Esfahany M. , Mohebalhojeh A. R. 
Published: June 2013

AbstractObservational studies show that the main energy source for developing cyclones is due to downstream radiation from existing upstream disturbances. This process is involved in the propagation of coherent wave packets linking the North Atlantic and Mediterranean storm tracks in winter. To understand the link, the Rossby wave packets have been analyzed for the winter season 2004/05 by means of wave envelope, energetic, and wave‐activity diagnostics. Two specifically selected cases are presented: one with clear propagation of the wave packet to the Mediterranean region from the North Atlantic storm track, and the other with zonal propagation of the wave packets along the central latitude of the North Atlantic storm track. The dynamical effects leading to the distinct propagation characteristics of the two cases are discussed. It is shown that the two cases make clear impacts on the horizontal flux of wave activity across a domain surrounding the Mediterranean storm track.
Intelligent combinatorial auctions of decentralized task assignment for AGV with multiple loading capacity
Authors: Fauadi Muhammad Haﬁdz Fazli bin Md , Yahaya Saifudin Haﬁz , Murata Tomohiro 
Published: June 2013

AbstractThe need to have an eﬃcient transportation system has attracted worldwide attention. Although there is increasing demand to implement distributed control system for industrial applications, there is still an unexplored potential of deploying distributed transportation system. This paper focuses on dynamic assignment of transportation requests to a ﬂeet of vehicles in real time. We introduce an improved combinatorial auction methodology to accommodate the distributed task assignment procedure. Based on a multiagent architecture, each vehicle is represented by an intelligent agent that bids for task and plans its own schedule. On the other hand, the auctioneer has the objective of minimizing transportation tardiness. An automated guided vehicle (AGV) has been selected as the case study, and numerical experiments have been carried out. The result obtained shows that the improved task assignment approach is able to produce performance competitive to a conventional task assignment. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Synthesis, Structures, and Properties of Two Novel Coordination Polymers with a V‐shaped Diphosphonate Ligand
Authors: Lv Xiaoxia , Tang Sifu , Li Liangjun , Xu Xianrui , Zhao Xuebo 
Published: June 2013

AbstractTwo novel coordination polymers, [Cu(H2L)(bipy)(H2O)2]·H2O (1) and [Ni2(H2L)(bipy)2.5(H2O)6]·(H2L)·7H2O (2) with the V‐shaped diphosphonate ligand (2,4,6‐trimethyl‐1,3‐phenylene)bis(methylene)diphosphonic acid (H4L) were synthesized via hydrothermal reactions in the presence of auxiliary ligand 4,4′‐bipyridine. Their structures were determined by single‐crystal X‐ray diffraction and further characterized by elemental analysis, infrared spectroscopy (IR), and thermogravimetric analysis (TGA). Compound 1 crystallizes in the Pnma space group and compound 2 crystallizes in the P21212 space group. They display square‐grid layer and bilayer two‐dimensional network, respectively.
Vapor Composition over Solid Indium Trichloride and in ­Indium Chloride Unsaturated Vapor
Authors: Tsirelnikov Viacheslav I. , Melnikov Petr , Nascimento Valter A. 
Published: June 2013

AbstractThe dependence of indium trichloride saturated and unsaturated vapor pressure on temperature was studied in the range of 630–950 K by static methods using a quartz membrane zero‐manometer and taking into account the volume of its working chamber and substance mass. The thermodynamic data on the process of dissociation of dimeric molecules and sublimation of monomer and dimer from solid indium trichloride were calculated: ΔH0subl InCl3(g)298 = 155.3 ± 6.2 kJ·mol–1; ΔS0subl InCl3(g)298 = 199.5 ± 7.9 J·mol–1·K–1; ΔH0subl In2Cl6(g)298 = 159.3 ± 6.2 kJ·mol–1; ΔS0subl In2Cl6(g)298 = 207.1±3.8 J·mol–1·K–1; ΔH0dis In2Cl6(g)298 = 152.6 ± 5.5 kJ·mol–1 and ΔS0dis In2Cl6(g)298 = 171.6 ± 5.2 J·mol–1·K–1. The saturated vapor over solid indium trichloride consists mainly of a mixture of monomeric and dimeric molecules (InCl3 and In2Cl6), and the content of the latter is slightly growing with increasing temperature.
Four Complexes with the Rigid Ligand 1,4‐Bis(1H‐imidazol‐4‐yl)benzene and Varied Carboxylate Ligands
Authors: Chen Shui‐Sheng , Qiao Rui , Sheng Liang‐Quan , Yang Song , Liu Zhao‐Di 
Published: June 2013

AbstractFour metal‐organic coordination polymers [Co2(L)3(nipa)2]·6H2O (1), [Cd(L)(nipa)]·3H2O (2), [Co(L) (Hoxba)2] (3) and [Ni2(L)2(oxba)2(H2O)]·1.5L·3H2O (4) were synthesized by reactions of the corresponding metal(II) salts with the rigid ligand 1,4‐bis(1H‐imidazol‐4‐yl)benzene (L) and different derivatives of 5‐nitroisophthalic acid (H2nipa) and 4,4′‐oxybis(benzoic acid) (H2oxba), respectively. The structures of the complexes were characterized by elemental analysis, FT‐IR spectroscopy and single‐crystal X‐ray diffraction. Complexes 1 and 3 have the same one‐dimensional (1D) chain while 2 is a 6‐connected twofold interpenetrating three‐dimensional (3D) network with α‐Po 412·63 topology based on the binuclear CdII subunits. Compound 4 features a puckered two‐dimensional (2D) (4,4) network, and the large voids of the packing 2D nets have accommodated the uncoordinated L guest molecules. An abundant of N–H···O, O–H···O and C–H···O hydrogen bonding interactions exist in complexes 1–4, which contributes to stabilize the crystal structure and extend the low‐dimensional entities into high‐dimensional frameworks. Lastly, the photoluminiscent properties of compounds 2 were also investigated.