bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Change in Thigh Muscle Strength Prior to and Concurrent With Minimum Clinically Important Worsening or Improvement in Knee Function: Data From the Osteoarthritis Initiative
Authors: Ruhdorfer Anja , Wirth Wolfgang , Eckstein Felix 
Published: November 2015

ObjectiveTo investigate whether a clinically relevant change in knee function in patients with or at risk for osteoarthritis (OA) of the knee is associated with concurrent or prior change in thigh muscle strength.MethodsParticipants in the Osteoarthritis Initiative (n = 2,675 [1,485 women and 1,190 men]) with available measurements of isometric muscle strength at baseline, 2‐year follow‐up, and 4‐year follow‐up were grouped into those with greater than minimum clinically important worsening (score of ≥6 [of a possible 68] on the Western Ontario and McMaster Universities Osteoarthritis Index function subscale) between 2‐year follow‐up and 4‐year follow‐up, those with greater than minimum clinically important improvement, and those without relevant change. Changes in isometric muscle strength concurrent with function change (between 2‐year follow‐up and 4‐year follow‐up) and preceding function change (between baseline and 2‐year follow‐up), with 95% confidence intervals (95% CIs), were determined, and differences between groups were assessed by analysis of covariance.ResultsConcurrent loss in extensor muscle strength in participants with worsening knee function during the 2‐year follow‐up−4‐year follow‐up period differed significantly from that in participants without change in knee function (−4.6% [95% CI −6.8, −2.4] and −2.2% [95% CI −3.0, −1.4], respectively; P = 0.03), as did the concurrent increase in strength among those with functional improvement (2.2% [95% CI −0.3, 4.7]; P < 0.0001). This increase in strength among subjects with improved function remained significantly different from the change in subjects with no change in function after adjustment for covariates, but was preceded by a greater loss in strength (−7.7% [95% CI −10.3, −5.0], P = 0.02) during the baseline−year 2 period compared to those without change in function during the year 2−year 4 period (−4.3% [95% CI −5.2, −3.4]). The decrease in strength during the baseline−year 2 period in those with worsening knee function during the year 2−year 4 period (−4.5% [95% CI −6.9, −2.2]) did not differ significantly from that in patients without a change in function (P = 0.87). No differences in changes in flexor muscle strength were observed between groups.ConclusionThese findings suggest that there is a positive concurrent longitudinal association between change in extensor muscle strength and worsening/improvement in knee function in patients with knee OA. However, a corresponding change in thigh muscle strength preceding the change in function was not observed.
In Vivo Therapeutic Success of MicroRNA‐155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage
Authors: Zhou Shiyu , Wang Yan , Meng Yao , Xiao Chunyuan , Liu Zheng , Brohawn Philip , Higgs Brandon W. , Jallal Bahija , Jia Qian , Qu Bo , Huang Xinfang , Tang Yuanjia , Yao Yihong , Harley John B. , Shen Nan 
Published: November 2015

ObjectiveDiffuse alveolar hemorrhage (DAH) is a rare but life‐threatening complication of systemic lupus erythematosus (SLE). Pristane‐treated B6 mice develop severe DAH within 2 weeks of treatment. MicroRNA‐155 (miR‐155) is a pleiotropic microRNA that plays a crucial role in the regulation of immune responses. Recent studies have revealed a pathogenic role of miR‐155 in various autoimmune disorders. The purpose of this study was to examine the role of miR‐155 in the development of DAH in pristane‐induced lupus using miR‐155–knockout (miR‐155−/−) mice and miR‐155 antagomir to silence miR‐155.MethodsDAH was induced by an intraperitoneal injection of 0.5 ml of pristane. MicroRNA‐155 antagomir was administered intravenously to silence miR‐155 expression. Lung tissues were collected for RNA extraction and were embedded in paraffin for sectioning. Gene expression profiling data were analyzed using Ingenuity Pathway Analysis. Real‐time quantitative polymerase chain reaction analysis was used for single‐gene validation. Luciferase reporter assay and argonaute 2 immunoprecipitation were performed for target validation.ResultsMicroRNA‐155 expression was significantly increased during the development of DAH. Disease progression was reduced in miR‐155−/− mice as well as by in vivo silencing of miR‐155 using a miR‐155 antagomir. MicroRNA‐155 silencing dampened pristane‐induced ectopic activation of multiple inflammatory pathways and reduced the expression of proinflammatory cytokines. Several negative regulators of NF‐κB signaling were inhibited by pristane and were reactivated in miR‐155−/− mice. In particular, the antiinflammatory factor peroxisome proliferator–activated receptor α was identified as a direct target of miR‐155.ConclusionMicroRNA‐155 promotes pristane‐induced lung inflammation. It contributes to ectopic activation of NF‐κB signaling pathways by targeting multiple negative regulators. MicroRNA‐155 antagomir may be a promising therapeutic strategy for treating acute lung inflammation in lupus.
The Incidence and Risk Factors for Psoriatic Arthritis in Patients With Psoriasis: A Prospective Cohort Study
Authors: Eder Lihi , Haddad Amir , Rosen Cheryl F. , Lee Ker‐Ai , Chandran Vinod , Cook Richard , Gladman Dafna D. 
Published: November 2015

ObjectiveTo estimate the incidence of psoriatic arthritis (PsA) in patients with psoriasis, and to identify risk factors for its development.MethodsThe study was designed as a prospective cohort study involving psoriasis patients who did not have a diagnosis of arthritis at the time of study enrollment. Information was collected about lifestyle habits, comorbidities, psoriasis activity, and medications. Patients who developed inflammatory arthritis or spondylitis were classified as having PsA if they fulfilled the criteria of the Classification of Psoriatic Arthritis Study group. The annual incidence of PsA was estimated using an event per person‐years analysis. Cox proportional hazards models, involving fixed and time‐dependent explanatory variables, were fitted to obtain estimates of the relative risk (RR) of the onset of PsA, determined in multivariate models stratified by sex and controlled for age at onset of psoriasis.ResultsThe data obtained from the 464 patients who were followed up for 8 years were analyzed. A total of 51 patients developed PsA during the 8 years since enrollment. The annual incidence rate of PsA was 2.7 cases (95% confidence interval 2.1–3.6) per 100 psoriasis patients. The following baseline variables were associated with the development of PsA in multivariate analysis: severe psoriasis (RR 5.4, P = 0.006), low level of education (university/college versus high school incomplete RR 0.22, P = 0.005; high school graduate versus high school incomplete RR 0.30, P = 0.049), and use of retinoid medications (RR 3.4, P = 0.02). In multivariate models with time‐dependent variables, psoriatic nail pitting (RR 2.5, P = 0.002) and uveitis (RR 31.5, P = 0.0002) were associated with the development of PsA.ConclusionThe incidence of PsA in patients with psoriasis is higher than previously reported. A severe psoriasis phenotype, presence of nail pitting, low level of education, and uveitis are predictive of the development of PsA in patients with psoriasis.
Robust Adaptive Soft Landing Control of an Electromagnetic Valve Actuator for Camless Engines
Authors: Mercorelli Paolo 
Published: November 2015

AbstractThis paper deals with a signal‐based robust adaptive approximation technique for a proportional derivative (PD) regulator which is applied to an electromagnetic valve actuator control for camless internal combustion engines. PD regulators generate very high spikes in the presence of unavoidable noise. These spikes cause high power dissipation and poor dynamic performance with a lack of precision. The presented method allows the reduction of the noise and not robust nonlinear uncertainties effects by using minimum variance analysis. The technique with which the PD regulator is approximated does not depend on the model of the controlled system. Hence, the technique is quite general and can be applied to any type of system. In addition, this paper describes a feasible real‐time self‐tuning of an approximated discrete PD regulator using a backward Euler technique. The main contribution of the paper is the presentation of an approximated PD controller using a minimum variance control strategy together with a weighted least squares method to adapt the parameters of this approximated controller. This control law realises a robust control technique with respect to the noise and nonlinear uncertainties. Moreover, a comparison with the approximate PD controller proposed in MATLAB by Mathworks is provided. The presented technique ensures a good dynamic performance, including low dissipation as well as accurate positioning and soft landing control.
Interaction between fasudil hydrochloride and bovine serum albumin: spectroscopic study
Authors: Yu Xianyong , Jiang Bingfei , Xun Caifang , Yao Qing 
Published: November 2015

AbstractThe interaction between fasudil hydrochloride (FSD) and bovine serum albumin (BSA) was investigated using fluorescence and ultraviolet spectroscopy under imitated physiological conditions. The Stern–Volmer quenching model has been successfully applied and the results revealed that FSD could quench the intrinsic fluorescence of BSA effectively via static quenching. The binding constants and binding sites for the BSA–FSD system were evaluated. The corresponding thermodynamic parameters obtained at different temperatures indicated that hydrophobic force played a major role in the interaction of FSD and BSA. The distance between the donor (BSA) and the acceptor (FSD) was obtained according to fluorescence resonance energy transfer (FRET). Synchronous fluorescence spectroscopy and FT‐IR spectra showed that the conformation of BSA was changed in the presence of FSD. Copyright © 2015 John Wiley & Sons, Ltd.
Polarity‐based fractionation in proteomics: hydrophilic interaction vs reversed‐phase liquid chromatography
Authors: Jafari M. , Mirzaie M. , Khodabandeh M. , Rezadoost H. , Ghassempour A. , Aboul‐Enein H. Y. 
Published: November 2015

AbstractDuring recent decades, hydrophilic interaction liquid chromatography (HILIC) ahs been introduced to fractionate or purify especially polar solutes such as peptides and proteins while reversed‐phase liquid chromatography (RPLC) is also a common strategy. RPLC is also a common dimension in multidimensional chromatography. In this study, the potential of HILIC vs RPLC chromatography was compared for proteome mapping of human peripheral blood mononuclear cell extract. In HILIC a silica‐based stationary phase and for RPLC a C18 column were applied. Then separated proteins were eluted to an ion trap mass spectrometry system. Our results showed that the HILIC leads to more proteins being identified in comparison to RPLC. Among the total 181 identified proteins, 56 and 38 proteins were fractionated specifically by HILIC and RPLC, respectively. In order to demonstrate this, the physicochemical properties of identified proteins such as polarity and hydrophobicity were considered. This analysis indicated that polarity may play a major role in the HILIC separation of proteins vs RPLC. Using gene ontology enrichment analysis, it was also observed that differences in physicochemical properties conform to the cellular compartment and biological features. Finally, this study highlighted the potential of HILIC and the great orthogonality of RPLC in gel‐free proteomic studies. Copyright © 2015 John Wiley & Sons, Ltd.
α‐Methylenation of Methyl Propanoate by the Catalytic Dehydrogenation of Methanol
Authors: Lorusso Patrizia , Coetzee Jacorien , Eastham Graham R. , Cole‐Hamilton David J. 
Published: November 2015

AbstractA one‐pot system for the conversion of methyl propanoate (MeP) to methyl methacrylate (MMA) has been investigated. In particular, this study is focused on the possibility of performing catalytic dehydrogenation of methanol for the in situ production of anhydrous formaldehyde, which is then consumed in a one‐pot base‐catalysed condensation with MeP to afford methyl 3‐hydroxy‐2‐methylpropanoate, which spontaneously dehydrogenates to MMA, some of which is subsequently hydrogenated to methyl 2‐methypropanoate (MiBu).
ChemInform Abstract: Crystallographic and Magnetic Descriptions of a Novel Erbium Rich Aluminide: Er10Co1+xAl3‐x (x = 0.30).
Authors: Nasri N. , Pasturel Mathieu , Dorcet V. , Belgacem B. , Ben Hassen R. , Tougait O. 
Published: November 2015

AbstractEr10Co1.3Al2.7 is prepared by arc melting of the elements followed by annealing (alumina crucible in evacuated silica ampoule, 1123 K, 1 week).
ChemInform Abstract: High‐Pressure Synthesis, Crystal Structures, and Properties of CdMn7O12 and SrMn7O12 Perovskites.
Authors: Glazkova Yana S. , Terada Noriki , Matsushita Yoshitaka , Katsuya Yoshio , Tanaka Masahiko , Sobolev Alexey V. , Presniakov Igor A. , Belik Alexei A. 
Published: November 2015

AbstractCdMn7O12 (I) and SrMn7‐xFexO12 (x = 0 (II), 0.08, 0.5) perovskites are prepared by hot pressing of stoichiometric mixtures of Mn2O3, MnO2, and CdO as well as Mn2O3, Fe2O3, and 4H‐SrMnO3, resp.
ChemInform Abstract: Synthesis of Garnet‐Type Li7La3Zr2O12 by Coprecipitation Method.
Authors: Hamao Naoki , Akimoto Junji 
Published: November 2015

AbstractThe title compound is synthesized by calcination (air, alumina crucible, 950 °C, 10 h) of a mixture of LiOH·H2O and a precursor obtained by coprecipitation from an aqueous solution of LaCl3, ZrOCl2, and LiOH.
ChemInform Abstract: Synthesis and Crystal Structure of a New Quinary Nitride: Li3Ca4(Ga3Ge)N8.
Authors: Park Dong Gon , DiSalvo Francis J. 
Published: November 2015

AbstractSingle crystals of the title compound are synthesized from mixtures of the corresponding metals and NaN3 in molten Na (Na:Ge:Ga:Ca:Li = 13:1:1:0.5:0.5, 760 °C, 48 h).
ChemInform Abstract: Synthesis and Single Crystal Study of CuMn3As2 and Cu2Mn4As3.
Authors: Uhlirova Klara , Tarasenko Robert , Martinez‐Casado Francisco Javier , Vondrackova Barbora , Matej Zdenek 
Published: November 2015

AbstractSingle crystals of CuMn3As2 (I) and Cu2Mn4As3 (II) are obtained from the elements in a Bi flux (Cu:Mn:As:Bi = 0.8:1.2:1:12; alumina crucible in evacuated quartz ampoule, 850 °C, 10 h).
ChemInform Abstract: High Pressure Synthesis of a New Phase of YbAg2: Structure, Valence of Yb and Properties.
Authors: Tsvyashchenko A. V. , et al.  
Published: November 2015

AbstractYbAg2 is obtained by melting the constituent elements under a pressure of 5 GPa (rock‐salt tubular ampoules with Ag end caps in a toroid‐type pressure cell, 1450 °C).
ChemInform Abstract: Mixed‐Valent Selenium Ligands in the Uncharged Iridium Complexes [Ir4Se10Br16] and [Ir6Se8Cl30].
Authors: Stolze Karoline , Rasche Bertold , Ruck Michael 
Published: November 2015

AbstractThe crystal structures of the new compounds (IV) and (VI) are determined by single crystal XRD.
ChemInform Abstract: Organocatalytic Enantioselective Aza‐Michael Reaction of Benzotriazole to β,β‐Disubstituted Nitroalkenes.
Authors: Chen Sheng‐Wei , Zhang Gui‐Cheng , Lou Qin‐Xin , Cui Wei , Zhang Sha‐Sha , Hu Wen‐Hui , Zhao Jun‐Ling 
Published: November 2015

Abstractleading to Michael adducts (III) bearing a quaternary stereogenic center
ChemInform Abstract: Catalytic Enantioselective Synthesis of α‐(Benzylamino)cyclobutanones.
Authors: Melis Nicola , Ghisu Lorenza , Guillot Regis , Caboni Pierluigi , Secci Francesco , Aitken David J. , Frongia Angelo 
Published: November 2015

Abstractvia tandem condensation/intramolecular rearrangement/proton transfer reaction of hydroxycyclobutanone and various secondary amines
ChemInform Abstract: New Phosphine—Imine Ligands Derived from D‐Gluco‐ and D‐Galactosamine in Pd‐Catalyzed Asymmetric Allylic Alkylation.
Authors: Szulc Izabela , Kolodziuk Robert , Kryczka Boguslaw , Zawisza Anna 
Published: November 2015

AbstractIt is demonstrated, that the carbohydrate based new phosphine‐imine (DGA) is an efficient ligand for the asymmetric allylic alkylation of acetate (I) with malonates.
ChemInform Abstract: [2:1] and [2:2] Cycloadducts from N‐Sulfonylamines and Azomethines.
Authors: Lender Andreas , Walker Nigel P. C. , Schaumann Ernst 
Published: November 2015

AbstractThe cycloaddition of N‐sulfonylamine (I) with azomethine (II) gives 2:1 cycloadduct (III).
ChemInform Abstract: Photoredox‐Catalyzed Reductive Coupling of Aldehydes, Ketones, and Imines with Visible Light.
Authors: Nakajima Masaki , Fava Eleonora , Loescher Sebastian , Jiang Zhen , Rueping Magnus 
Published: November 2015

AbstractIn the photocatalytic protocol tributylamine acts not only as an electron donor but also serves to activate the substrates, thus allowing the coupling of aldehydes, ketones, and imines under mild conditions.
ChemInform Abstract: Chiral Rh Phosphine—Phosphite Catalysts Immobilized on Ionic Resins for the Enantioselective Hydrogenation of Olefins in Water.
Authors: Kleman P. , Barbaro P. , Pizzano A. 
Published: November 2015

AbstractHigh conversions and high enantioselectivities are obtained in the hydrogenation of acrylates of type (I) using a chiral rhodium catalyst immobilized on an ionic resin.
ChemInform Abstract: Design of Modified Amine Transfer Reagents Allows the Synthesis of α‐Chiral Secondary Amines via CuH‐Catalyzed Hydroamination.
Authors: Niu Dawen , Buchwald Stephen L. 
Published: November 2015

AbstractThe described method for the synthesis of chiral secondary amines uses a modified monoalkylamine transfer reagent, which limits side and competitive reactions of previously reported methods.
ChemInform Abstract: Direct N‐Methylation Reaction Using DMSO as One‐Carbon Bridge: Convenient Access to Heterocycle‐Containing β‐Amino Ketones.
Authors: Sun Kai , Wang Xin , Jiang Yongqing , Lv Yunhe , Zhang Liping , Xiao Beibei , Li Donghui , Zhu Zhonghong , Liu Lin 
Published: November 2015

AbstractA series of acetyl heteroarenes (I) and (V) are selectively converted into the corresponding β‐amino ketones (IV) via a novel oxidative C—S bond cleavage reaction of DMSO (II) for dual C—C and C—N bond formation.
ChemInform Abstract: Iodoarene‐Catalyzed Stereospecific Intramolecular sp3 C—H Amination: Reaction Development and Mechanistic Insights.
Authors: Zhu Chendan , Liang Yong , Hong Xin , Sun Heqing , Sun Wei‐Yin , Houk K. N. , Shi Zhuangzhi 
Published: November 2015

AbstractA new method for preparation of γ‐lactams through iodoarene‐catalyzed intramolecular amination is developed.
ChemInform Abstract: Direct Arylation of 5‐Iodouracil and 5‐Iodouridine with Heteroarenes and Benzene via Photochemical Reaction.
Authors: Yang Qian , Wei Tao , He Yun , Liang Yong , Zhang Zun‐Ting 
Published: November 2015

AbstractThe radical arylation reactions proceed smoothly without use of transition metals or ligands.
ChemInform Abstract: Palladium Nanoparticles Supported on Sulfonic Acid Functionalized Silica as Trifunctional Heterogeneous Catalysts for Heck and Suzuki Reactions.
Authors: Oger Nicolas , Le Grognec Erwan , Felpin Francois‐Xavier 
Published: November 2015

AbstractThe catalyst is successfully applied in the 3‐step synthesis of the fungicide boscalid (XVII).
ChemInform Abstract: A Modified Procedure for the Palladium Catalyzed Borylation/Suzuki—Miyaura Cross‐Coupling of Aryl and Heteroaryl Halides Utilizing Bis‐boronic Acid.
Authors: Molander Gary A. , Trice Sarah L.J. , Tschaen Brittany 
Published: November 2015

AbstractNotable advantages of the improved one‐pot protocol using ethylene glycol as an additive are increased yields, shorter reaction times and a broader substrate scope.
ChemInform Abstract: Highly Efficient Aerobic Oxidation of Alcohols by Using Less‐Hindered Nitroxyl‐Radical/Copper Catalysis: Optimum Catalyst Combinations and Their Substrate Scope.
Authors: Sasano Yusuke , Kogure Naoki , Nishiyama Tomohiro , Nagasawa Shota , Iwabuchi Yoshiharu 
Published: November 2015

AbstractThe corresponding carbonyl compounds are efficiently obtained under mild reaction conditions from various alcohols, including highly hindered and heteroatom‐rich ones.
ChemInform Abstract: Nucleophilic Difluoro(trimethylsilyl)methylation of Arylidene Meldrum′s Acids.
Authors: Volodin Alexander D. , Zemtsov Artem A. , Levin Vitalij V. , Struchkova Marina I. , Dilman Alexander D. 
Published: November 2015

AbstractThe addition of arylidene Meldrum′s acid with difluoro(trimethylsilyl)methyl zinc bromide (II) followed by hydrolization, decarboxylation and esterification affords β‐Me3SiCF2 substituted esters of type (V).
ChemInform Abstract: A Metal‐Free Approach for Transamidation of Amides with Amines in Aqueous Media.
Authors: Srinivas Mahesuni , Hudwekar Abhinandan D. , Venkateswarlu Vunnam , Reddy G. Lakshma , Kumar K. A. Aravinda , Vishwakarma Ram A. , Sawant Sanghapal D. 
Published: November 2015

AbstractThe title method furnishing amides in excellent yields can be carried out under microwave irradiation as well as conventional heating conditions.
ChemInform Abstract: Synthesis of Polycycles by Single or Double Domino Nucleophilic Substitution/Diels—Alder Reaction.
Authors: Camps Pelayo , Lozano David , Font‐Bardia Merce 
Published: November 2015

AbstractKey step in the synthesis of novel bridged polycycles is a single or double domino nucleophilic substitution of neopentyl‐type iodides with potassium cyclopentadienide, followed by an intramolecular Diels—Alder cycloaddition.
ChemInform Abstract: Visible Light Photoredox Catalysis: Regioselective Radical Addition of Aminoalkyl Radicals to 2,3‐Allenoates.
Authors: Dai Xiaojun , Mao Renjie , Guan Baochuan , Xu Xiaoliang , Li Xiaonian 
Published: November 2015

AbstractUnsaturated γ‐aminobutyric ester derivatives are efficiently obtained by a simple method.
ChemInform Abstract: Aryl Alkyl Carbene—Pd Complex Assisted C—Cl Bond Activation: An Unprecedented Cross‐Coupling Route to trans‐Stilbenes.
Authors: Jha Abadh Kishor , Kishor Shyam , Jain Nidhi 
Published: November 2015

AbstractTrans‐stilbenes are highly regio‐ and stereospecifically obtained by microwave assisted reaction of various aryl chlorides with 1‐(bromoethyl)benzene.
ChemInform Abstract: Sonogashira Cross‐Coupling in a Designer Ionic Liquid (IL) Without Copper, External Base, or Additive, and with Recycling and Reuse of the IL.
Authors: Srinivas Reddy A. , Laali Kenneth K. 
Published: November 2015

AbstractThe facile protocol uses the ionic liquid (ILQ), which acts as both solvent and base in the Sonogashira coupling to afford a wide variety of internal alkynes including SF5‐substituted derivatives (V).
ChemInform Abstract: Alkyne‐Mediated Approach to the Synthesis of (4R,5R)‐5‐Hydroxy‐4‐decanolide and (‐)‐Muricatacin.
Authors: Raji Reddy Chada , Suman Devatha , Narsimha Rao Nagavaram 
Published: November 2015

Abstract(4R,5R)‐5‐hydroxy‐4‐decanolide (IIIa) and (‐)‐muricatacin (IIIb) are stereoselectively synthesized starting in a new six‐step reaction sequence involving the Sonogashira coupling for the desired carbon‐chain extension followed by Sharpless asymmetric dihydroxylation to construct the hydroxy‐lactone framework as key steps.
ChemInform Abstract: An Alternative to Precious Metals: Hg(ClO4)2·3H2O as a Cheap and Water‐Tolerant Catalyst for the Cycloisomerization of Allenols.
Authors: Alcaide Benito , Almendros Pedro , Luna Amparo , Soriano Elena 
Published: November 2015

AbstractA wide range of 2,5‐dihydrofurans are efficiently and selectively obtained by Hg‐catalyzed cycloisomerization of allenols.
ChemInform Abstract: Selective Thiolative Lactonization of Internal Alkynes Bearing a Hydroxyl Group with Carbon Monoxide and Organic Disulfides Catalyzed by Transition‐Metal Complexes
Authors: Higashimae Shinya , Tamai Taichi , Nomoto Akihiro , Ogawa Akiya 
Published: November 2015

AbstractPd(PPh3)4 or Co2(CO)8