bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structured caustic vector vortex optical field: manipulating optical angular momentum flux and polarization rotation
Authors: Chen Rui-Pin , Chen Zhaozhong , Chew Khian-Hooi , Li Pei-Gang , Yu Zhongliang , Ding Jianping , He Sailing 
Published: May 2015

AbstractA caustic vector vortex optical field is experimentally generated and demonstrated by a caustic-based approach. The desired caustic with arbitrary acceleration trajectories, as well as the structured states of polarization (SoP) and vortex orders located in different positions in the field cross-section, is generated by imposing the corresponding spatial phase function in a vector vortex optical field. Our study reveals that different spin and orbital angular momentum flux distributions (including opposite directions) in different positions in the cross-section of a caustic vector vortex optical field can be dynamically managed during propagation by intentionally choosing the initial polarization and vortex topological charges, as a result of the modulation of the caustic phase. We find that the SoP in the field cross-section rotates during propagation due to the existence of the vortex. The unique structured feature of the caustic vector vortex optical field opens the possibility of multi-manipulation of optical angular momentum fluxes and SoP, leading to more complex manipulation of the optical field scenarios. Thus this approach further expands the functionality of an optical system.
Characterization of the antibody response against EV71 capsid proteins in Chinese individuals by NEIBM-ELISA
Authors: Ding Yingying , Chen Xuguang , Qian Baohua , Wu Guorong , He Ting , Feng Jiaojiao , Gao Caixia , Wang Lili , Wang Jinhong , Li Xiangyu , Cao Mingmei , Peng Heng , Zhao Chunyan , Pan Wei 
Published: May 2015

AbstractHuman enterovirus 71 (EV71) has become the major pathogen of hand, foot and mouth disease (HFMD) worldwide, while the anti-EV71 antibody responses other than neutralizing epitopes have not been characterized. In this study, EV71 capsid proteins VP1, VP3, VP0 and various VP1 antigens were constructed to analyze anti-EV71 response in severe HFMD cases, non-HFMD outpatient children and normal adults using a novel evolved immunoglobulin-binding molecule (NEIBM)-based ELISA. The high prevalence of antibody responses against all three capsid proteins was demonstrated and anti-EV71 VP1 showed the main antibody response. Anti-EV71 VP1 antibody response was found to predominantly target to epitopes based on the common enterovirus cross-reactive sequence. Moreover, inhibition pattern against anti-EV71 VP1 reactions in three groups was obviously different. Taken together, these results firstly characterized the anti-EV71 antibody responses which are predominantly against VP1 epitopes based on common enterovirus cross-reactive sequence. This finding could be helpful for the better understanding of anti-EV71 humoral immunity and useful for seroepidemiological surveillance.
The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels
Authors: Chen Yi-An , Peng Yi-Jheng , Hu Meng-Chun , Huang Jing-Jia , Chien Yun-Chia , Wu June-Tai , Chen Tsung-Yu , Tang Chih-Yung 
Published: May 2015

AbstractVoltage-gated CLC-1 chloride channels play a critical role in controlling the membrane excitability of skeletal muscles. Mutations in human CLC-1 channels have been linked to the hereditary muscle disorder myotonia congenita. We have previously demonstrated that disease-associated CLC-1 A531V mutant protein may fail to pass the endoplasmic reticulum quality control system and display enhanced protein degradation as well as defective membrane trafficking. Currently the molecular basis of protein degradation for CLC-1 channels is virtually unknown. Here we aim to identify the E3 ubiquitin ligase of CLC-1 channels. The protein abundance of CLC-1 was notably enhanced in the presence of MLN4924, a specific inhibitor of cullin-RING E3 ligases. Subsequent investigation with dominant-negative constructs against specific subtypes of cullin-RING E3 ligases suggested that CLC-1 seemed to serve as the substrate for cullin 4A (CUL4A) and 4B (CUL4B). Biochemical examinations further indicated that CUL4A/B, damage-specific DNA binding protein 1 (DDB1) and cereblon (CRBN) appeared to co-exist in the same protein complex with CLC-1. Moreover, suppression of CUL4A/B E3 ligase activity significantly enhanced the functional expression of the A531V mutant. Our data are consistent with the idea that the CUL4A/B-DDB1-CRBN complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 channels.
PAX6 does not regulate Nfia and Nfib expression during neocortical development
Authors: Bunt Jens , Lim Jonathan W. C. , Zhao Lu , Mason Sharon , Richards Linda J. 
Published: May 2015

AbstractThe Nuclear factor I (NFI) family of transcription factors regulates proliferation and differentiation throughout the developing central nervous system. In the developing telencephalon of humans and mice, reducedNfiexpression is associated with agenesis of the corpus callosum and other neurodevelopmental defects. Currently, little is known about howNfiexpression is regulated during early telencephalic development. PAX6, a transcription factor important for telencephalic development, has been proposed as an upstream regulator ofNfiexpression in the neocortex. Here we demonstrate that, in the developing neocortex of mice, NFIA and NFIB are endogenously expressed in gradients with high caudo-medial to low rostro-lateral expression and are most highly expressed in the cortical plate. We found that this expression pattern deviates from that of PAX6, suggesting that PAX6 does not driveNfiexpression. This is supported byin vitroreporter assays showing that PAX6 over-expression does not regulateNfipromoter activity. Similarly, we also found that in thePax6 Small Eyemutant, no changes inNfimRNA or protein expression are observed in the neocortical ventricular zone where PAX6 and the NFIs are expressed. Together these data demonstrate that in mice, PAX6 is not a transcriptional activator ofNfiexpression during neocortical development.
Efficient delivery of antigen to DCs using yeast-derived microparticles
Authors: Pan Ying , Li Xiaopeng , Kang Tianyi , Meng Hui , Chen Zhouli , Yang Li , Wu Yang , Wei Yuquan , Gou Maling 
Published: May 2015

AbstractSome pathogens can be naturally recognized and internalized by antigen presentation cells (APCs) in vivo, providing a platform for efficient vaccine delivery. However, the biosafety concerns discourage the clinical applications of live pathogens. Here, yeast-derived microparticles were prepared for cancer vaccine delivery. By chemical treatment of bread yeast, capsular yeast shell (YS) microparticles were obtained. Ovalbumin (OVA), as a model antigen, was conjugated to the surface of YS. Results indicated that these YS microparticles with a uniform size of ~3.4 μm can be recognized and internalized by dendritic cells (DCs). The YS-mediated antigen delivery can enhance the cellular uptake of antigen by DCs, promote the maturation of DCs and trigger DCs to release immune co-stimulatory molecules. Immunization with YS-mediated antigen can induce an effective immune response against tumor cells in vivo, with contributions from both humoral and cellular immunity. This work suggests that yeast shell microparticles as efficient vaccine delivery system has promising applications in cancer immunotherapy.
New breast cancer prognostic factors identified by computer-aided image analysis of HE stained histopathology images
Authors: Chen Jia-Mei , Qu Ai-Ping , Wang Lin-Wei , Yuan Jing-Ping , Yang Fang , Xiang Qing-Ming , Maskey Ninu , Yang Gui-Fang , Liu Juan , Li Yan 
Published: May 2015

AbstractComputer-aided image analysis (CAI) can help objectively quantify morphologic features of hematoxylin-eosin (HE) histopathology images and provide potentially useful prognostic information on breast cancer. We performed a CAI workflow on 1,150 HE images from 230 patients with invasive ductal carcinoma (IDC) of the breast. We used a pixel-wise support vector machine classifier for tumor nests (TNs)-stroma segmentation and a marker-controlled watershed algorithm for nuclei segmentation. 730 morphologic parameters were extracted after segmentation and 12 parameters identified by Kaplan-Meier analysis were significantly associated with 8-year disease free survival (P < 0.05 for all). Moreover, four image features including TNs feature (HR 1.327, 95%CI [1.001 - 1.759], P = 0.049), TNs cell nuclei feature (HR 0.729, 95%CI [0.537 - 0.989], P = 0.042), TNs cell density (HR 1.625, 95%CI [1.177 - 2.244], P = 0.003) and stromal cell structure feature (HR 1.596, 95%CI [1.142 - 2.229], P = 0.006) were identified by multivariate Cox proportional hazards model to be new independent prognostic factors. The results indicated that CAI can assist the pathologist in extracting prognostic information from HE histopathology images for IDC. The TNs feature, TNs cell nuclei feature, TNs cell density and stromal cell structure feature could be new prognostic factors.
Time-resolved imaging of pulse-induced magnetization reversal with a microwave assist field
Authors: Rao Siddharth , Rhensius Jan , Bisig Andre , Mawass Mohamad-Assaad , Weigand Markus , Kläui Mathias , Bhatia Charanjit S. , Yang Hyunsoo 
Published: May 2015

AbstractThe reversal of the magnetization under the influence of a field pulse has been previously predicted to be an incoherent process with several competing phenomena such as domain wall relaxation, spin wave-mediated instability regions and vortex-core mediated reversal dynamics. However, there has been no study on the direct observation of the switching process with the aid of a microwave signal input. We report a time-resolved imaging study of magnetization reversal in patterned magnetic structures under the influence of a field pulse with microwave assistance. The microwave frequency is varied to demonstrate the effect of resonant microwave-assisted switching. We observe that the switching process is dominated by spin wave dynamics generated as a result of magnetic instabilities in the structures and identify the frequencies that are most dominant in magnetization reversal.
Slow Spin Dynamics in Superconducting Ca0.9Ce0.1Fe2As2
Authors: Nadeem K. , Zhang W. , Chen D. Y. , Ren Z. A. , Qiu X. G. 
Published: May 2015

AbstractSlow spin dynamics has been observed in superconducting under-doped Ca0.9Ce0.1Fe2As2 single crystal. Below 100 K, the system exhibits hysteresis in the cooling and warming protocols of temperature dependent resistivity due to first order tetragonal to orthorhombic structural transition with simultaneous magnetic transition from paramagnetic to spin density wave antiferromagnetic state of the iron (Fe) ions. Zero field cooled/field cooled (ZFC/FC) magnetization curves showed splitting at 32 K followed by a sharp increase of the FC curve and then FC plateau at low temperatures. Slow spin relaxation in both the ZFC and FC protocols was observed which is typical for spin-glass system. The system also showed features analogue to spin-glass behavior such as ZFC peak, FC plateau, ZFC slow spin relaxation, magnetic hysteresis and ZFC ac memory effect. The spin-glass like behavior was rather weak and vanished at higher fields. The origin of the slow spin dynamics could be the inhomogeneous distribution of the cerium (Ce) spins ordered along the c-axis OR interactions between Fe and Ce spins which lead to magnetic frustration of Ce spins. All these findings support the coexistence of slow spin dynamics of Ce spins and superconductivity in Ca0.9Ce0.1Fe2As2 single crystal.
Biodistribution and function of extracellular miRNA-155 in mice
Authors: Bala Shashi , Csak Timea , Momen-Heravi Fatemeh , Lippai Dora , Kodys Karen , Catalano Donna , Satishchandran Abhishek , Ambros Victor , Szabo Gyongyi 
Published: May 2015

AbstractCirculating miRNAs can be found in extracellular vesicles (EV) and could be involved in intercellular communication. Here, we report the biodistribution of EV associated miR-155 using miR-155 KO mouse model. Administration of exosomes loaded with synthetic miR-155 mimic into miR-155 KO mice resulted in a rapid accumulation and clearance of miR-155 in the plasma with subsequent distribution in the liver, adipose tissue, lung, muscle and kidney (highest to lowest, respectively). miR-155 expression was detected in isolated hepatocytes and liver mononuclear cells of recipient KO mice suggesting its cellular uptake. In vitro, exosome-mediated restoration of miR-155 in Kupffer cells from miR-155 deficient mice augmented their LPS-induced MCP1 mRNA increase. The systemic delivery of wild type plasma to miR-155 KO mice also resulted in a rapid accumulation of miR-155 in the circulation and distribution to the liver and adipose tissue. In summary, our results demonstrate tissue biodistribution and biologic function of EV-associated miR-155.
Meta-analysis of the association of MTHFR polymorphisms with multiple myeloma risk
Authors: Ma Li-Min , Ruan Lin-Hai , Yang Hai-Ping 
Published: May 2015

AbstractThe association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with multiple myeloma (MM) risk has been explored, but the results remain controversial. Thus, a meta-analysis was performed to provide a comprehensively estimate. The case-control studies about MTHFR C677T and A1298C polymorphisms with MM risk were collected by searching PubMed, Elsevier, China National Knowledge Infrastructure and Wanfang Databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the strength of association. Overall, no significant association was found between MTHFR A1298C polymorphism and MM risk under all four genetic models (AC vs. AA, OR = 0.99, 95%CI = 0.82-1.20; CC vs. AA, OR = 1.14, 95%CI = 0.77-1.68; recessive model, OR = 1.10, 95%CI = 0.76-1.59; dominant model, OR = 1.01, 95%CI = 0.84-1.22). The risk was also not significantly altered for C677T polymorphism and MM in overall comparisons (CT vs. CC, OR = 1.04, 95%CI = 0.93-1.17; TT vs. CC, OR = 1.16, 95%CI = 0.98-1.37; recessive model, OR = 1.13, 95%CI = 0.98-1.32; dominant model, OR = 1.07, 95%CI = 0.96-1.20). In subgroup analyses by ethnicity, no significant association was observed in both Caucasians and Asians. This meta-analysis suggested that MTHFR polymorphisms were not associated with MM risk.
A Late Devonian Fertile Organ with Seed Plant Affinities from China
Authors: Wang Deming , Liu Le , Guo Yun , Xue Jinzhuang , Meng Meicen 
Published: May 2015

AbstractSeed plants underwent first major evolutionary radiation in the Late Devonian (Famennian), as evidenced by the numerous ovules described to date. However, the early pollen organs are underrepresented, so that their structure and evolution remain poorly known. Here we report a new taxon of pollen organ Placotheca minuta from the Late Devonian. The synangium consists of many basally and more or less laterally fused microsporangia borne on the margin of a pad. The prepollen is spherical and trilete. The appearance of Famennian synangia especially in Placotheca does not support the current understanding that the earliest pollen organs closely resembled the fructifications of the ancestral progymnosperms. Placotheca indicates earlier diversification of pollen organs than previously expected and is highly derived among the early pollen organs with trilete prepollen. It is suggested that, immediately after the origination of seed plants, pollen organs had evolved at a rapid rate, whereas their prepollen remained primitively spore-like.
Electromagnetically induced absorption in a three-resonator metasurface system
Authors: Zhang Xueqian , Xu Ningning , Qu Kenan , Tian Zhen , Singh Ranjan , Han Jiaguang , Agarwal Girish S. , Zhang Weili 
Published: May 2015

AbstractMimicking the quantum phenomena in metamaterials through coupled classical resonators has attracted enormous interest. Metamaterial analogs of electromagnetically induced transparency (EIT) enable promising applications in telecommunications, light storage, slow light and sensing. Although the EIT effect has been studied extensively in coupled metamaterial systems, excitation of electromagnetically induced absorption (EIA) through near-field coupling in these systems has only been sparsely explored. Here we present the observation of the EIA analog due to constructive interference in a vertically coupled three-resonator metamaterial system that consists of two bright and one dark resonator. The absorption resonance is one of the collective modes of the tripartite unit cell. Theoretical analysis shows that the absorption arises from a magnetic resonance induced by the near-field coupling of the three resonators within the unit cell. A classical analog of EIA opens up opportunities for designing novel photonic devices for narrow-band filtering, absorptive switching, optical modulation and absorber applications.
Follower ants in a tandem pair are not always naïve
Authors: Schultheiss Patrick , Raderschall Chloé A , Narendra Ajay 
Published: May 2015

AbstractIn addition to foraging individually several species of ants guide nestmates to a goal by tandem running. We found that the Australian ant, Camponotus consobrinus, forages both individually and by tandem running to head to the same goal, nest-specific native Australian trees on which they forage. While paths of solitary foragers and initial paths of tandem followers showed no differences in heading directions or straightness, tandem followers moved at about half the speed of solitary runs. When leaders were experimentally removed, follower ants initially engaged in a systematic search around the point of interruption, following which they either (a) headed directly towards and successfully reached the foraging trees, or (b) continued searching or (c) returned to the nest. The high incidence of followers that successfully navigated towards the foraging trees on their own provides strong evidence that many tandem followers are in fact experienced foragers. Detailed analysis of the searching behaviour revealed that even seemingly lost followers displayed a directional bias towards the foraging trees in their search path. Our results show that in a foraging context follower ants in a tandem pair are not always naïve.
Signal detection analysis of blindsight in monkeys
Authors: Yoshida Masatoshi , Isa Tadashi 
Published: May 2015

AbstractMacaque monkeys with a unilateral lesion in V1 have been used as an animal model of blindsight. While objective proof of blindsight requires that the two aspects of blindsight (residual forced-choice localization and attenuated yes-no detection) should be tested under identical stimulus conditions using bias-free measures of sensitivity, these have not been attained in studies of nonhuman primates. Here we tested two macaque monkeys with a unilateral V1 lesion with two saccade tasks using identical stimuli: a forced-choice (FC) task and a yes-no (YN) task. An analysis based on signal detection theory revealed that sensitivity in the FC task was significantly higher than that in the YN task. Such dissociation of sensitivity between the two tasks was not observed when near-threshold visual stimuli were presented in the normal, unaffected hemifield. These results suggest that the V1-lesioned monkeys resemble the well-studied blindsight patient G.Y., whose visual experience per se was completely abolished.
Necking and notch strengthening in metallic glass with symmetric sharp-and-deep notches
Authors: Sha Z. D. , Pei Q. X. , Liu Z. S. , Zhang Y. W. , Wang T. J. 
Published: May 2015

AbstractNotched metallic glasses (MGs) have received much attention recently due to their intriguing mechanical properties compared to their unnotched counterparts, but so far no fundamental understanding of the correlation between failure behavior and notch depth/sharpness exists. Using molecular dynamics simulations, we report necking and large notch strengthening in MGs with symmetric sharp-and-deep notches. Our work reveals that the failure mode and strength of notched MGs are strongly dependent on the notch depth and notch sharpness. By increasing the notch depth and the notch sharpness, we observe a failure mode transition from shear banding to necking and also a large notch strengthening. This necking is found to be caused by the combined effects of large stress gradient at the notch roots and the impingement and subsequent arrest of shear bands emanating from the notch roots. The present study not only shows the failure mode transition and the large notch strengthening in notched MGs, but also provides significant insights into the deformation and failure mechanisms of notched MGs that may offer new strategies for the design and engineering of MGs.
Indigenes’ Responses to Immigrants’ Consumer Acculturation: A Relational Configuration Analysis
Authors: Luedicke Marius K. 
Published: May 2015

AbstractConsumer research commonly conceptualizes consumer acculturation as a project that immigrants pursue when adjusting their consumer identities and practices to unfamiliar sociocultural environments. This article broadens this prevailing view by conceptualizing consumer acculturation as a relational, interactive adaptation process that involves not only immigrant consumption practices but also indigenes who interpret and adjust to these practices, thereby shaping the paths of possibility for mutual adaptation. Based on a Fiskenian relational configuration analysis, the study shows how indigenes in a rural European town interpret certain immigrant consumption practices as manifestations of a gradual sell-out of the indigenous community, a crumbling of their authority, a violation of equality rules, and of indigenes being torn between contradictory micro- and macro-social morals. The article contributes a broader conceptualization of consumer acculturation, highlights four sources of ethnic group conflict in a consumer acculturation context, and demonstrates the epistemic value of Fiskenian relational configuration analysis for consumer culture theory.
Turning to Space: Social Density, Social Class, and the Value of Things in Stores
Authors: O’Guinn Thomas Clayton , Tanner Robin J. , Maeng Ahreum 
Published: May 2015

Abstract
This article is about social space and material objects for sale within that space. We draw primarily on Goffman’s (1971) concepts of use space and possession territories to predict that as the social density of a given space increases, inferences of the subjective social class and income of people in that space fall. Eight studies confirm that this is indeed the case, with the result holding even for stick figures, thus controlling for typical visual indicators of social class such as clothing or jewelry. Furthermore, these social class inferences mediate a relationship between social density and product valuation, with individuals assessing both higher prices and a greater willingness to pay for products presented in less crowded contexts. This effect of inferred class on product valuation is explained by status-motivated individuals’ desire to associate with higher-status people. To the best of our knowledge, this research is the first to reveal the link between social density, status inferences, and object valuations. As such, it makes a novel contribution to what has come to be known in sociology as the topological turn: a renewed focus on social space.