bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulfur Imidations by Light‐Induced Ruthenium‐Catalyzed Nitrene Transfer Reactions
Authors: Bizet Vincent , Bolm Carsten 
Published: March 2015

AbstractN‐Acyl nitrenes have been generated from a range of heterocyclic precursors, and their applications in light‐induced ruthenium‐catalyzed sulfur imidations have been studied. Analyzing the reaction scope and determining the structural requirements of the in situ formed electrophilic nitrogen species for effective nitrene transfer allowed a mechanistic scheme to be proposed. The mechanistic conclusions were substantiated by the identification of potential intermediates.
Short‐Term Intensive Family Therapy for Adolescent Eating Disorders: 30‐Month Outcome
Authors: Marzola Enrica , Knatz Stephanie , Murray Stuart B. , Rockwell Roxanne , Boutelle Kerri , Eisler Ivan , Kaye Walter H. 
Published: March 2015

AbstractFamily therapy approaches have generated impressive empirical evidence in the treatment of adolescent eating disorders (EDs). However, the paucity of specialist treatment providers limits treatment uptake; therefore, our group developed the intensive family therapy (IFT)—a 5‐day treatment based on the principles of family‐based therapy for EDs. We retrospectively examined the long‐term efficacy of IFT in both single‐family (S‐IFT) and multi‐family (M‐IFT) settings evaluating 74 eating disordered adolescents who underwent IFT at the University of California, San Diego, between 2006 and 2013. Full remission was defined as normal weight (≥95% of expected for sex, age, and height), Eating Disorder Examination Questionnaire (EDE‐Q) global score within 1 SD of norms, and absence of binge–purging behaviours. Partial remission was defined as weight ≥85% of expected or ≥95% but with elevated EDE‐Q global score and presence of binge–purging symptoms (<1/week). Over a mean follow‐up period of 30 months, 87.8% of participants achieved either full (60.8%) or partial remission (27%), while 12.2% reported a poor outcome, with both S‐IFT and M‐IFT showing comparable outcomes. Short‐term, intensive treatments may be cost‐effective and clinically useful where access to regular specialist treatment is limited. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
On the impact of user segmentation and behaviour analysis over traffic generation in beyond 4G networks
Authors: Gonçalves Luís Carlos , Sebastião Pedro , Souto Nuno , Correia Américo 
Published: March 2015

AbstractIn this paper, a survey of the mobile data traffic growth over the last decade is performed, showing historically how data consumption patterns have evolved. Based on the results from the survey and the most important factors for unprecedented traffic growth from last years, a set of user‐centric services and scenarios are identified as the most prevalent by 2020. Based on service characteristics and subscribers' behaviour and consumption regarding traffic generation, four user segments are derived. All these factors allow introducing an impact model that characterises user segment's behaviour over post‐4G cellular networks, namely, its consistency and stability towards traffic generation, data consumption and service usage, providing mobile network operators with relevant information to predict user segment dispersion, stability and risk. Real and estimated market data are used to test the impact model, and most relevant results are shown. Overall, the proposed impact model aims to bring together technological, sociological and also economical perspectives into a single analytical framework, meeting both mobile network operators and subscriber's expectations of high quality of service with continuous cost decrease. Copyright © 2015 John Wiley & Sons, Ltd.
The State of Preparing Evaluators
Authors: LaVelle John M. , Donaldson Stewart I. 
Published: March 2015

AbstractThis chapter begins with an analysis of the prior status of the preparation of evaluators and what is going on currently in that regard. The varied, noticeably diverse, and growing options for individuals to enter the field are explained with some recent studies highlighted. The discussion goes beyond traditional university‐based programs to include those delivered by evaluation associations, distance education, and other mechanisms. One of the conclusions is a recommendation to more fully delve into what is now taking place and to dig more deeply into how evaluators enter the profession. © Wiley Periodicals, Inc., and the American Evaluation Association.
Credentialed Evaluator Designation Program, the Canadian Experience
Authors: Kuji‐Shikatani Keiko 
Published: March 2015

AbstractThe Credentialed Evaluator (CE) designation is a service provided by Canadian Evaluation Society (CES) to its members, who may elect to become credentialed on a voluntary basis. The designation means that the holder has provided evidence of the education and experience required by the CES to be a competent evaluator. The author briefly examines the impetus for the CE designation, the value it represents for the Canadian evaluation community, the development of the system including structure and administration, and how it is evolving as we learn from professionalizing evaluation in Canada. Concerns expressed during the development of the Competencies for Canadian Evaluation Practice mirrored those expressed about the development of a professional designation. The CE designation is about providing a path for new evaluators and a clearer direction for more established evaluators for their ongoing development. © Wiley Periodicals, Inc., and the American Evaluation Association.
Suppressive function of low‐dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha–induced nuclear factor‐kappa B signaling
Authors: Liu Yu‐Peng , Lee Jih‐Jong , Lai Tsung‐Ching , Lee Chien‐Hsin , Hsiao Ya‐Wen , Chen Po‐Shen , Liu Wei‐Ting , Hong Chi‐Yuan , Lin Se‐Kwan , Ping Kuo Mark‐Yen , Lu Pei‐Jung , Hsiao Michael 
Published: March 2015

AbstractBackgroundDeguelin has both antiproliferation and antimetastasis activities. However, high‐dose deguelin elicits many undesired side effects. The purpose of this study was to investigate whether the low‐dose deguelin can prevent the metastasis of oral cancer.MethodsThe dose effects of deguelin on metastasis of oral cancer cells were analyzed by in vitro invasion assay and an orthotropic xenograft mouse model. The involvement of tumor necrosis factor alpha (TNF‐α)‐induced nuclear factor‐kappa B (NF‐κB) signaling was examined by Western blot and reporter assay.ResultsLow‐dose deguelin, which has minimal cytotoxicity, significantly inhibited the invasion and migration of oral cancer cells. These inhibitory effects of low‐dose deguelin were mediated by suppressing TNF‐α‐induced activation of IκB kinase leading to the inhibition of IκB phosphorylation, NF‐κB transcriptional activity, and matrix metalloproteinase‐2 (MMP2) expression. The low‐dose deguelin treatment significantly inhibited tumor growth and invasion without systemic toxicity.ConclusionThe low‐dose deguelin suppressed the invasion and migration of oral cancer by downregulating TNF‐α‐induced NF‐κB signaling. © 2015 Wiley Periodicals, Inc. Head Neck 38: E524–E534, 2016
Establishment of a novel human papillomavirus–negative and radiosensitive head and neck squamous cell carcinoma cell line
Authors: Kim Kyung‐Min , Park Eun‐Ji , Yeo Jiyoung , Joo Young‐Hoon , Cho Kwang‐Jae , Kim Min‐Sik 
Published: March 2015

AbstractBackgroundThe purpose of this study was to develop a CMCSCC−1 cell line for head and neck cancer research into new therapies for head and neck squamous cell carcinoma (HNSCC).MethodsThe CMCSCC‐1 cell line was isolated from a primary oral tongue tumor specimen of a female patient. Tumor cells were evaluated for biomarkers expression by Western blots, reverse transcriptase‐polymerase chain reaction (RT‐PCR), fluorescence activated cell sorter, and immunostaining. Cell proliferation in response to radiation was measured by the WST‐8 assay.ResultsThe characterization analyses revealed a typical epithelial morphology; a doubling time of approximately 24 hours, high tumorigenicity in immunodeficient mice, and upregulated biomarkers. CMCSCC‐1 cells were negative for human papillomavirus (HPV) infection, but more sensitive to radiation compared with those FaDu cell lines.ConclusionCMCSCC‐1, a novel oral tongue SCC cell line, was established. It will help in the elucidation of the molecular pathogenesis of HPV‐negative radiosensitive tumors. © 2015 Wiley Periodicals, Inc. Head Neck 38: E542–E551, 2015
Phase II trial of bevacizumab + cetuximab + cisplatin with concurrent intensity‐modulated radiation therapy for patients with stage III/IVB head and neck squamous cell carcinoma
Authors: Fury Matthew G. , Xiao Han , Sherman Eric J. , Baxi Shrujal , Smith–Marrone Stephanie , Schupak Karen , Gewanter Richard , Gelblum Daphna , Haque Sofia , Schoder Heiko , Shah Jatin P. , Katabi Nora , Kurtzman Rachel , Lipson Brynna , Cox Lisa , Lee Nancy Y. , Pfister David G. 
Published: March 2015

AbstractBackgroundThe purpose of this study was to evaluate the efficacy and tolerability of the addition of 2 monoclonal antibodies, bevacizumab and cetuximab, to 2 cycles of high‐dose cisplatin administered concurrently with intensity‐modulated radiation therapy (IMRT) for head and neck squamous cell carcinoma (HNSCC).MethodsPatients with newly diagnosed stage III/IVB (M0) HNSCC received cetuximab (400 mg/m2 loading dose, followed by 250 mg/m2 weekly), bevacizumab (15 mg/kg, days 1 and 22), and cisplatin (50 mg/m2, days 1, 2, 22, and 23) concurrently with IMRT (70 Gy). The primary endpoint was progression‐free survival (PFS). Secondary endpoints were overall survival (OS) and safety and tolerability.ResultsAmong 30 patients enrolled in this study, the primary tumor site was the oropharynx in 24 patients (p16 immunohistochemistry was positive in 17, negative in 1, and not done in 6 of the oropharyngeal tumors). Median age was 57 years (range, 38–77 years) and 27 patients had clinical stage IVA disease. All patients completed the full planned dose of radiation therapy. The most common ≥ grade 3 adverse events were lymphopenia, mucositis (functional), and dysphagia. With a median follow‐up of 33.8 months, 2‐year PFS was 88.5% (95% confidence interval [CI] = 68.1–96.1) and 2‐year OS was 92.8% (95% CI = 74.2–98.1).ConclusionThe addition of bevacizumab and cetuximab to 2 cycles of cisplatin, given concurrently with IMRT, was well‐tolerated and was associated with favorable efficacy outcomes in this patient population. © 2015 Wiley Periodicals, Inc. Head Neck 38: E566–E570, 2016
Prognostic evaluation of percentage variation of metabolic tumor burden calculated by dual‐phase 18FDG PET‐CT imaging in patients with head and neck cancer
Authors: Abgral Ronan , Valette Gérald , Robin Philippe , Rousset Jean , Keromnes Nathalie , Le Roux Pierre‐Yves , Marianowski Rémi , Salaün Pierre‐Yves 
Published: March 2015

AbstractBackgroundThe purpose of this study was to investigate the prognostic value of percentage variation of metabolic tumor burden in patients with head and neck squamous cell carcinoma (HNSCC).MethodsPatients referred to undergo 18fluorodeoxyglucose (FDG) positron emission tomography (PET)‐CT for staging of HNSCC were included in this study. Using a dual‐phase method, standardized uptake value maximum (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were recorded and respectively used to calculate retention index (RI), %ΔMTV, and %ΔTLG. Recurrence‐free survival (RFS) was determined by Kaplan–Meier method and compared with studied PET parameters in univariate and multivariate.ResultsSeventy patients (61 men/9 women; 62.9 ± 9.1 years old) were included. In univariate, SUVmax, RI, MTV, and TLG (p ≤ .0001) were significantly correlated with RFS, unlike %ΔMTV (p = 137) and %ΔTLG (p = .517). In multivariate, RI (p = .005) and MTV (p = .022) persisted as independent prognostic factors.ConclusionOur results did not prove a prognostic interest of percentage variation of metabolic tumor burden in patients with HNSCC but confirmed that RI and MTV are independently correlated with RFS. © 2015 Wiley Periodicals, Inc. Head Neck 38: E600–E606, 2016
Early oral cancer diagnosis: The Aarhus statement perspective. A systematic review and meta‐analysis
Authors: Seoane Juan , Alvarez–Novoa Pablo , Gomez Iria , Takkouche Bahi , Diz Pedro , Warnakulasiruya Saman , Seoane–Romero Juan M. , Varela–Centelles Pablo 
Published: March 2015

ABSTRACTBackgroundMortality is linked to diagnostic intervals in certain cancers. As symptom perception is conditioned by tumor site, a specific study on oral cancer is needed.MethodsThis study's inclusion criteria were original data, symptomatic primary oral squamous cell carcinoma, and exposure of interest, diagnostic interval, or diagnostic delay. The outcome of interest was survival and disease stage. A meta‐analysis was undertaken to investigate the relationship between intervals to diagnosis, TNM classification, and survival in oral cancer.ResultsRegarding referral delay, the results present no heterogeneity and showed a risk increase in mortality of 2.48 (range = 1.39–4.42). The larger the diagnostic delay, the more advanced the stage at diagnosis. High quality studies reveal a higher risk increase than low quality studies (odds ratio [OR] = 2.44; 95% confidence interval [CI] = 1.36–4.36 vs OR = 1.53; 95% CI = 1.26–1.86).ConclusionA longer time interval from first symptom to referral for diagnosis is a risk factor for advanced stage and mortality of oral cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2182–E2189, 2016
Development of an adaptive monitoring framework for long-term programs: An example using indicators of fish health
Authors: Arciszewski Tim J , Munkittrick Kelly R 
Published: March 2015

Abstract
Detecting unwanted changes associated with localized human activities in aquatic ecosystems requires defining the value of an indicator expected at a site in the absence of development. Ideally, adequate and comparable baseline data will be collected at an exposure location before that development, but this is rarely done. Instead, comparisons are made using various designs to overcome the inadequate or missing baseline data. Commonly these comparisons are done over short periods, using information from local reference sites to estimate variability expected at the exposed site. Results of these truncated designs are often evaluated using p values that may have little bearing on ecologically relevant changes. To remedy the reliance of studies on small datasets collected at reference sites, other designs emphasize regional analyses, but these may be insensitive to site-specific changes. Some designs also may forego discussing the consequences of detecting any differences. A new monitoring framework has been proposed to use existing solutions, simplify analysis, and focus on the detection of meaningful changes. It is illustrated here by using data on fish health from a large-scale, long-term program in the Moose River basin in northern Ontario. This framework advocates interpretation of data at multiple scales: within-site, locally, and regionally. The primary focus is on estimating a range from a probability distribution of historical data collected at a specific location where 95% of future observations are predicted to occur. Changes at the exposed site are also compared with historical and contemporary expectations from proximate and regional reference sites. Critical effect sizes also can be derived from regional reference data to evaluate the magnitude of differences observed between any 2 sites. Any unexpected changes inform future monitoring decisions provided by a priori guidance. Adoption of this framework extends the utility of monitoring programs in which commitments to long-term collections have been made, advocates harmonization of studies over time and space, and focuses attention on unusual observations. Integr Environ Assess Manag 2015;X:000–000. ©2015 SETAC.
Key Points
Understanding the relevance of changes is difficult and is an overlooked component of monitoring studies. Ecological relevance can be described with critical effect sizes and normal ranges. Critical effect sizes can be defined by sampling reference sites. Monitoring can be evaluated at multiple spatial and temporal scales to better understand the relevance of changes.
Varying RGD concentration and cell phenotype alters the expression of extracellular matrix genes in vocal fold fibroblasts
Authors: Kosinski Aaron M. , Sivasankar M. Preeti , Panitch Alyssa 
Published: March 2015

AbstractThe impact of RGD integrin binding‐peptide concentration and cell phenotype on directing extracellular matrix (ECM) gene expression in vocal fold fibroblasts is little understood. Less is known about cell response to RGD concentration on a biomaterial when fibroblasts are in a scar‐like environment compared to a healthy environment. We investigated the effects of varying RGD integrin‐binding peptide surface concentration on ECM gene expression of elastin, collagen type 3 alpha 1, decorin, fibronectin, hyaluronan synthase 2, and collagen type 1 alpha 2 in scarred and unscarred immortalized human vocal fold fibroblasts (I‐HVFFs). Phenotype and RGD concentration affected ECM gene expression. Phenotype change from healthy to myofibroblast‐like resulted in ECM gene up‐regulation for all genes tested, except for decorin. Systematically altering RGD concentration affected the expression of elastin and collagen type 3 alpha 1 in a myofibroblast phenotype. Specifically greater up‐regulation in gene expression was observed with higher RGD concentrations. This research demonstrates that controlling RGD concentration may influence ECM gene expression levels in fibroblasts. Such knowledge is critical in developing the next generation of bioactive materials that, when implanted into sites of tissue damage and scarring, will direct cells to regenerate healthy tissues with normal ECM ratios and morphologies. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3094–3100, 2015.
Triethylbenzylammonium Chloride as a Useful and Efficient Catalyst for the Alkylation of Indole/substituted Indoles in Water: A Comparative Study between Conventional and Microwave Irradiation
Authors: Tumtina Shokip , Kathing Chingrishon , Phucho Ivulho Tovishe , Nongrum Ridaphun , Myrboh Bekington , Nongkhlaw Rishanlang 
Published: March 2015

AbstractA green and facile method for the alkylation of indole/substituted indole in water using a phase Transfer catalyst (Triethylbenzylammonium Chloride, TEBA) to synthesise bis‐indolyl methanes (BIMs) and Michael addition of indole to α,β‐unsaturated carbonyl compounds is reported. The substitution of indoles occurred exclusively at the 3‐position and products of N‐alkylation has not been observed. However, for 3‐substituted indoles, reactions were found to occur at the 2‐position. A comparative study between conventional heating and microwave irradiation has also been reported.
A morphological novelty for feeding and sound production in the yellowtail clownfish
Authors: Olivier Damien , Frédérich Bruno , Herrel Anthony , Parmentier Eric 
Published: March 2015

ABSTRACTThe yellowtail clownfish Amphiprion clarkii is able to close its mouth very quickly by means of the cerato‐mandibular (c‐md) ligament, a synapomorphic trait of Pomacentridae joining the hyoid bar to the medial part of the lower jaw. This fast closure induces tooth collision, thus producing sounds that the clownfish uses during agonistic behaviors. To investigate whether this rapid jaw movement is also used during feeding, we analyzed the kinematics of sound production and feeding. Sound production, feeding on live planktonic prey, and feeding on food attached to tweezers was filmed with a high‐speed camera. Three kinds of kinematic patterns were detected and were associated with the two different types of food presented: one performed to catch planktonic prey (PP), and two (called B‐1 and B‐2) to bite attached food items. The kinematic pattern of B‐2 is similar to that observed during sound production (SP) and the transection of the c‐md ligament highlights that sound production and biting‐2 motions are dependent on this morphological trait. Our data show that the c‐md ligament in addition to its role in sound production allows duplication of the mouth‐closing mechanism during feeding. This highlights the key role played by the c‐md ligament in sound production and feeding on attached prey. J. Exp. Zool. 323A: 227–238, 2015. © 2015 Wiley Periodicals, Inc.
Computational approach to radiogenomics of breast cancer: Luminal A and luminal B molecular subtypes are associated with imaging features on routine breast MRI extracted using computer vision algorithms
Authors: Grimm Lars J. , Zhang Jing , Mazurowski Maciej A. 
Published: March 2015

PurposeTo identify associations between semiautomatically extracted MRI features and breast cancer molecular subtypes.MethodsWe analyzed routine clinical pre‐operative breast MRIs from 275 breast cancer patients at a single institution in this retrospective, Institutional Review Board‐approved study. Six fellowship‐trained breast imagers reviewed the MRIs and annotated the cancers. Computer vision algorithms were then used to extract 56 imaging features from the cancers including morphologic, texture, and dynamic features. Surrogate markers (estrogen receptor [ER], progesterone receptor [PR], human epidermal growth factor receptor‐2 [HER2]) were used to categorize tumors by molecular subtype: ER/PR+, HER2− (luminal A); ER/PR+, HER2+ (luminal B); ER/PR−, HER2+ (HER2); ER/PR/HER2− (basal). A multivariate analysis was used to determine associations between the imaging features and molecular subtype.ResultsThe imaging features were associated with both luminal A (P = 0.0007) and luminal B (P = 0.0063) molecular subtypes. No association was found for either HER2 (P = 0.2465) or basal (P = 0.1014) molecular subtype and the imaging features. A P‐value of 0.0125 (0.05/4) was considered significant.ConclusionLuminal A and luminal B molecular subtype breast cancer are associated with semiautomatically extracted features from routine contrast enhanced breast MRI. J. Magn. Reson. Imaging 2015;42:902–907.
Aspergillus oryzae fermented germinated soybean extract alleviates perimenopausal symptoms in ovariectomised rats
Authors: Jeong Mingeum , Lee Dong Sung , Suh Hyung Joo , Park Yooheon 
Published: March 2015

AbstractBACKGROUNDSoybeans have been widely used to alleviate climacteric symptoms. In this study, we investigated the oestrogenic activities of isoflavones extracted from Aspergillus oryzae‐challenged germinated soybeans (AO‐GS). Eight‐week‐old virgin Sprague–Dawley female rats were ovariectomised (OVX). The rats were orally administered 0.1 mg kg−1 17α‐ethinyl oestradiol or three different doses of AO‐GS (0.5, 1.0 2.0 g kg−1 day−1) in distilled water for 6 weeks, while control rats were administered vehicle alone. Uterine weights and levels of oestradiol and testosterone in serum were measured. In addition to serum parameters, bone parameters were also acquired by using micro‐computed tomography scanning.RESULTSTreatments of OVX rats with AO‐GS changed the secretory profile of serum oestradiol and testosterone. Serum oestradiol levels were significantly increased in OVX rats treated with and AO‐GS (0.5, 1.0, 2.0 g kg−1 day−1), while serum testosterone levels were not significantly increased in OVX rats treated with 1.0 g kg−1 day−1 of AO‐GS. Furthermore, AO‐GS (2.0 g kg−1 day−1) significantly attenuated bone loss, increased trabecular bone volume fraction and trabecular thickness, and significantly decreased trabecular pattern factor.CONCLUSIONAO‐GS treatments caused moderate oestrogenic activity in OVX rats compared to those treated with oestradiol, suggesting the potential for the use of AO‐GS in the treatment of menopausal symptoms and in osteoporosis caused by oestrogen deficiency. © 2015 Society of Chemical Industry