bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Nanoparticles for Cancer Theranostics: A Critical Review on Design, Synthesis, and Multifunctional Capabilities
Authors: Raka Saurabh , Belemkar Sateesh , Bhattacharya Sankha 
Published: June 2024

Abstract:
Theranostics, a method that combines targeted therapy and diagnostic imaging,
has emerged as a viable route for enhancing cancer treatment, and hybrid nanoparticles
(HNPs) are at the forefront of this field. Metallic, polymeric, lipid-based, and silica-
based HNPs are studied for targeting and biocompatibility. Using HNPs, chemotherapeutic
drugs, small interfering RNA, and therapeutic genes can be given precisely and
controlled. This enhances therapeutic efficacy and reduces adverse effects. With fluorescence
dyes, MRI contrast agents, and PET tracers, real-time therapy response monitoring
is conceivable. A nano platform with therapeutic and diagnostic capabilities holds
great promise for personalized medicine and precision oncology. The present study discusses
HNPs' biocompatibility, stability, immunogenicity, and long-term biosafety,
which are crucial to the clinical translation of cancer theranostics. Further, in this in-
-depth investigation, we investigated the design, synthesis, and multifunctional activities
of HNPs for use in cancer theranostics.
Nanocarriers: Exploring the Potential of Oligonucleotide Delivery
Authors: Alsaidan Omar Awad 
Published: June 2024

Abstract:
Nanoparticle-based delivery systems have emerged as promising tools in oligonucleotide therapeutics, facilitating precise and targeted delivery to address several disease conditions. The multifaceted landscape of nanoparticle-based oligonucleotide delivery encompasses the
fundamental aspects of nanotechnology in delivery systems, various classes of oligonucleotides,
and the growing field of ON-based therapeutics. These ON-based therapeutics are utilized to target specific genetic sequences within cells, offering promising avenues for treating various diseases by regulating gene expression or interfering with specific cellular processes. The integration of
nanotechnology in delivery systems offers several advantages, given their intricate systems. Being
a diverse class of agents, oligonucleotides provide a wide range of potential owed to each class of
agents that support therapeutic interventions. Oligonucleotide-based platforms have demonstrated
their versatility in molecular targeting and intervention strategies. Moreover, the complexities and
delivery challenges in oligonucleotide therapeutics are expected to be overcome by the application
of nanotechnology-based platforms.Because nanoparticles can overcome biological barriers and
improve bioavailability, stability, and specificity, their role in developing oligonucleotide delivery
systems is greatly valued. The innovative solutions facilitated by nanoparticles are efficient strategies to address the arduous barriers. These strategies beat obstacles like enzymatic degradation,
cellular uptake, and immune response, which in turn paves the way for enhanced therapeutic efficacy. This review paper intends to explore the various applications of nanoparticle-mediated oligonucleotide delivery in a variety of diseases. It outlines the promising growth of therapies enabled by these systems, extending from cancer to genetic disorders, neurodegenerative diseases,
etc. We have underscored the pivotal role of nanoparticle-based delivery systems in uncovering
the full potential of oligonucleotide therapeutics, thereby fostering advancements in precision
medicine and targeted therapies.
Exploring the Relationship between ACE Gene Variants and Systemic
Lupus Erythematosus Susceptibility in the Hainan Population through
Genetic Association Analysis
Authors: Lin Guiling , Zhuang Yanping , Zhang Xuan , Zhang Qi , Wu Huitao , Xu Wenlu , Wang Zhe , He Ziman , Su Linglan , Jia Xiaokang , Gong Aimin 
Published: June 2024

Background:
The purpose of this study was to determine the association between single nucleotide polymorphisms (SNPs) at the rs4331, rs4341, and rs4351 loci of the angiotensinconverting enzyme (ACE) gene and genetic susceptibility to systemic lupus erythematosus (SLE)
in the Hainan population.

Methods:
This study involved a total of 428 participants, with 214 individuals diagnosed with
SLE and an equal number of healthy controls. The SNaPshot sequencing technique was used to determine the base sequences at the ACE gene rs4331, rs4341, and rs4351 loci in the study subjects.
Logistic regression was employed to compare the frequency distribution of genotypes and allele
frequencies at each locus between the case group and the control group. HaploView 4.2 software
was used to analyze the relationship between haplotypes at each locus and genetic susceptibility to
SLE.

Results:
The GG genotype and G allele frequency at the rs4341 locus were higher in the case
group compared to the control group. In the rs4341 recessive model, carriers of the GG genotype
were more likely to develop SLE compared to carriers of the CG+CC genotype (OR = 1.889, 95%
CI: 1.195-2.988, P = 0.006). In the rs4351 overdominant model, carriers of the AC genotype had
an increased risk of developing SLE compared to carriers of the AA+CC genotype (OR = 1.514,
95% CI: 1.033-2.219, P = 0.033). The rs4341 and rs4351 loci exhibited linkage disequilibrium,
and the CA haplotype (OR = 0.630, 95% CI: 0.481-0.826, P = 0.001) was a protective factor
against SLE. The GA haplotype (OR = 2.849, 95% CI: 1.901-4.270, P < 0.01) and the CC haplotype (OR = 2.309, 95% CI: 1.210-4.405, P = 0.009) were risk factors for genetic susceptibility to
SLE in the Hainan population.

Conclusion:
The rs4341 locus of the ACE gene is associated with genetic susceptibility to SLE in
the Hainan population
The Combination of Gd-EOB-DTPA Enhanced T1 Mapping with Apparent
Diffusion Coefficient could Improve the Diagnostic Efficacy of Hepatocellular
Carcinoma Grading
Authors: He Hui , Li Xiaotian , Liu Jing , Tong Qiuyun , Ling Min , Zeng Zisan , Zhou Zhipeng 
Published: June 2024

Background::
Accurately predicting the hepatocellular carcinoma (HCC) grade may facilitate the rational selection of treatment strategies. The diagnostic
efficacy of the combination of Gadolinium ethoxybenzy diethylenetriamine pentaacetic (Gd-EOB-DTPA) enhancement T1 mapping and apparent
diffusion coefficient (ADC) values in predicting HCC grade needs further validation.

Objectives::
This study aimed to assess the capacity of Gd-EOB-DTPA-enhanced T1 mapping and ADC values, both individually and in combination, to
discriminate between different grades of HCC.

Materials and Methods::
From July 2017 to February 2020, 96 patients (male, 83; mean age, 53.67 years; age range, 29-71 years) clinically diagnosed with HCC were
included in the present study. All patients underwent Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI, including T1 mapping
sequence) before surgery or biopsy. All the patients were categorized into 3 groups according to the pathological results (including 24 cases of
well-differentiated HCCs, 59 cases of moderately differentiated HCCs, 13 cases of and poorly differentiated HCCs). The mean Gd-EOB-DTPA
enhanced T1 values (ΔT1=[(T1pre-T1post)/T1pre]×100%) and ADC values between different grading groups of HCC were calculated and
compared. The area under the characteristics curve (AUC), the diagnostic threshold, sensitivity, and specificity of ΔT1 and ADC for differential
diagnosis were analyzed.

Results::
Mean ΔT1 was 58% for well-differentiated HCCs, 50% for moderately-differentiated HCCs, and 43% for poorly-differentiated HCCs. ΔT1 showed
statistical differences between the groups (P<0.001). The mean ADC values of the 3 groups were 1.11×10−3 mm2/s, 0.91×10−3 mm2/s, and
0.80×10−3mm2/s, respectively. ADC showed statistical differences between the groups (P<0.001). In discriminating well- differentiated group
from the moderately differentiated group, the AUC of ΔT1 was 0.751 (95% CI: 0.642, 0.859), the AUC of ADC was 0.782 (95% CI: 0.671, 0.894),
the AUC of combined model was 0.811 (95% CI: 0.709, 0.914). In discriminating the poorly differentiated group from the moderately
differentiated group, the AUC of ΔT1 was 0.768 (95% CI: 0.634, 0.902), the AUC of ADC was 0.754 (95% CI: 0.603, 0.904), and the AUC of the
combined model was 0.841 (95% CI: 0.729, 0.953).

Conclusion::
Gd-EOB-DTPA enhanced T1 mapping, and ADC values have complementary effects on the sensitivity and specificity for identifying different
HCC grades. A combined model of Gd-EOB-DTPA-enhanced MRI T1 mapping and ADC values could improve diagnostic performance for
predicting HCC grades.
Phytochemicals as Autophagy Modulators in Hepatocellular Carcinoma
Authors: Ghosh Nibedita , James Rajana , Saha Dipankar , Das Bhrigu Kumar 
Published: June 2024

Background:
Hepatocellular carcinoma (HCC) poses a threat to human health due to
several risk factors associated with one’s lifestyle, including liver cirrhosis, alcohol intake, obesity, exposure to aflatoxin, hepatitis B and/or C virus infection, non-alcoholic steatohepatitis
(NASH), diabetes and many other factors. The treatment of HCC involves several distinct approaches, including significant advancement in surgical interventions. Given the toxicity of conventional medicines or the need for a suitable approach focusing on the stages of HCC progression, the current treatment is not very effective, which brings a significant focus on improving
alternative-targeted approaches as anti-HCC moieties.

Objective:
Therefore, this review provides an update on how the phytoconstituents exhibit their
anti-HCC effect by intervening in the control of autophagy

Methods:
This study conducted a thorough literature search on hepatocellular carcinoma (HCC),
autophagy, and phytoconstituents. The search was performed using multiple search engines and
the main keywords, and only English publications published before April 2023 were included.

Results:
One of the various molecular-mediated mechanisms used in cancer therapies is ‘Autophagy,’ a metabolic process whereby cellular stress causes damaged cells to be cleared out to preserve cellular homeostasis and provide cells with the nutrients they need to survive. Because of its
dual activity as a tumor suppressor or tumorigenesis, autophagy-mediated manipulation could be
a promising option for treating cancer

Conclusion:
Phytochemicals derived from natural sources offer an antitumorigenic effect and
reduce the probability of HCC by regulating autophagy-mediated mechanisms and functioning as
tumor suppressors.
A Comprehensive Review of Nanomaterials as Potential Weapons against
Multidrug-Resistant Staphylococcus aureus
Authors: Devliya Bhargav , Patel Bimalkumar , Chauhan Shreya J , Patel Hitesh D. 
Published: June 2024

Abstract:
Multidrug-resistant Staphylococcus aureus is a serious public health problem with high
fatality rates and difficult treatment. Conventional antimicrobials are limited in their effectiveness
against MRSA due to developing resistance mechanisms and protective biofilms. Nanomaterials
present a potential alternative since they offer targeted drug delivery and synergetic effects of nanoconjugates, eradicate biofilms, and use photothermal and photodynamic therapies. Furthermore, the
discovery of nanovaccines holds the potential for enhancing immune responses against multidrugresistant S. aureus. Nanoparticles show considerable promise in the battle against multidrugresistant S. aureus, but significant obstacles remain, including determining their possible toxicity,
scalability, and cost-effectiveness for widespread clinical application. However, by overcoming
these barriers, nanomaterial-based techniques provide a viable route for tackling multidrug resistance in S. aureus, opening the path for a future in which successful therapies are within reach.
The Association of Broadband Internet Use With Drug Overdose Mortality Rates in the United States: Cross-Sectional Analysis
Authors: Karakis Ioannis , Kostandini Genti , Tsamakis Konstantinos , Zahirovic-Herbert Velma 
Published: June 2024

Background
The availability and use of broadband internet play an increasingly important role in health care and public health.

Objective
This study examined the associations between broadband internet availability and use with drug overdose deaths in the United States.

Methods
We linked 2019 county-level drug overdose death data in restricted-access multiple causes of death files from the National Vital Statistics System at the US Centers for Disease Control and Prevention with the 2019 county-level broadband internet rollout data from the Federal Communications Commission and the 2019 county-level broadband usage data available from Microsoft’s Airband Initiative. Cross-sectional analysis was performed with the fixed-effects regression method to assess the association of broadband internet availability and usage with opioid overdose deaths. Our model also controlled for county-level socioeconomic characteristics and county-level health policy variables.

Results
Overall, a 1% increase in broadband internet use was linked with a 1.2% increase in overall drug overdose deaths. No significant association was observed for broadband internet availability. Although similar positive associations were found for both male and female populations, the association varied across different age subgroups. The positive association on overall drug overdose deaths was the greatest among Hispanic and Non-Hispanic White populations.

Conclusions
Broadband internet use was positively associated with increased drug overdose deaths among the overall US population and some subpopulations, even after controlling for broadband availability, sociodemographic characteristics, unemployment, and median household income.
Evaluasi Sistem Pencatatan dan Pelaporan dalam Implementasi Program PONED di Kabupaten Purbalingga
Authors: Ismiratri Nia , Hasanbasri Mubasysyir , Marthias Tiara 
Published: June 2024

Peningkatan derajat kesehatan akan dapat terwujud apabila terdapat rancangan sistem yang baik. Sistem informasi kesehatan merupakan salah satu komponen dasar di dalam sistem kesehatan karena dari sistem informasi kesehatan akan didapatkan data yang berkualitas, sebagai sumber informasi dan dasar pengambilan keputusan di masing-masing blok atau komponen lain pada sistem kesehatan. Namun, sistem pencatatan dan pelaporan sebagai salah satu instrumen dalam sistem informasi, seringkali menjadi masalah yang dihadapi di berbagai organisasi pelayanan kesehatan, salah satunya pada penyelenggaraan PONED di Puskesmas dalam rangka percepatan penurunan AKI dan AKB. Secara umum penelitian ini bertujuan untuk mengeksplorasi bagaimana pelaksanaan program PONED di Kabupaten Purbalingga. Tujuan khusus penelitian ini adalah mengevaluasi sistem pencatatan dan pelaporan program PONED, peran bidan koordinator PONED, dan penanganan keluhan pelanggan sebagai salah satu alat monitoring dan evaluasi program PONED. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif yang dilaksanakan di Puskesmas Karangmoncol dan Dinas Kesehatan Kabupaten Purbalingga. Data dikumpulkan melalui wawancara mendalam, observasi dan penelusuran dokumen. Hasil penelitian menunjukkan bahwa masih adanya tim PONED di Puskesmas yang personilnya belum tersertifikasi pelatihan PONED. Sistem pencatatan dan pelaporan program PONED di Kabupaten Purbalingga masih dilaksanakan secara manual dan belum dilakukan analisis maupun penyajian secara tertib. Peran bidan koordinator di Puskesmas maupun di Dinas Kesehatan belum berjalan optimal. Mekanisme untuk mendapatkan umpan balik dari pelanggan PONED sudah dilaksanakan melalui berbagai media, namun belum dilaksanakan analisis umpan balik dari pelanggan untuk menentukan langkah perbaikan yang perlu dilakukan. Kesimpulan yang diperoleh adalah penyelenggaraan PONED di Kabupaten Purbalingga sudah berjalan, meskipun belum termonitor dan terevaluasi secara tertib. Sistem pencatatan dan pelaporan juga sudah dilaksanakan, namun belum dapat dipastikan kualitas data yang didapatkan, karena belum ada mekanisme yang diatur mengenai analisis dan penyajian data. Kata kunci: keluhan pelanggan, evaluasi, pencatatan dan pelaporan, Puskesmas PONED.
Analisis Kesiapan Penerapan Rekam Medis Elektronik RSUD Bandar Negara Husada Provinsi Lampung Tahun 2023
Authors: Kapitan Rifki , Farich Achmad , Perdana Agung Aji 
Published: June 2024

Permenkes Republik Indonesia Nomor 24 Tahun 2022 tentang Rekam Medis, menyebutkan bahwa seluruh Fasilitas Pelayanan Kesehatan harus menyelenggarakan Rekam Medis Elektronik (RME) paling lambat pada tanggal 31 Desember 2023. Tujuan penelitian ini adalah untuk mengetahui kesiapan penerapan rekam medis elektronik di RSUD Bandar Negara Husada Provinsi Lampung tahun 2023. Jenis penelitian kualitatif, dengan rancangan studi kasus. Penelitian dilakukan di RSUD Bandar Negara Husada Provinsi Lampung dari bulan Juli sampai dengan bulan Agustus 2023. Jumlah subyek penelitian sebanyak 6 informan, yaitu Direktur, Kepala Bidang Program, Hukum dan Informasi, Kepala Seksi Hukum dan Informasi, Kepala Rekam Medis, Tenaga Informasi Teknologi (IT), dan Kepala Seksi Perencanaan. Pengumpulan data dengan metode wawancara, telaah dokumentasi, dan observasi. Keabsahan data menggunakan triangulasi. Analisis data meliputi reduksi data, display data, dan penarikan kesimpulan. Hasil penelitian didapatkan, kesiapan penerapan RME mendapatkan dukungan dari aspek manajemen dan pemangku kepentingan, aspek analisa pemangku kepentingan, aspek persiapan operasional, dan aspek teknologi, namun terdapat satu aspek yang belum mendukung kesiapan penerapan RME, yaitu aspek pelatihan. Rumah sakit belum melakukan pelatihan bagi tenaga operasional dan pengguna akhir. Secara umum dapat dikatakan RSUD Bandar Negara Husada siap menerapkan RME namun perlu melakukan perbaikan pada beberapa aspek terutama pada aspek pelatihan. Penanggung jawab penyelenggara RME yaitu Kepala Seksi Hukum dan Informasi perlu melakukan percepatan untuk mengadakan pelatihan bagi pegawai untuk menggunakan RME agar rumah sakit sepenuhnya siap menerapkan RME.
Reducing Unmet Need for Family Planning in Indonesia: A Policy Analysis Report
Authors: Frans Sandra , Djasri Hanevi 
Published: June 2024

The Indonesian government has already initiated many policies to reduce unmet need for Family Planning (FP), which is one of the three zeros commitment. It is crucial to understand whether a regulatory perspective is sufficient to solve the unmet need for family planning in Indonesia. This report explores the policy response to the unmet need of FP in Indonesia. This report draws from two sets of data. First, a document review contained 45 policies. The second set of data was qualitative interviews with the key informants collected as part of the policy analysis process of unmet need of FP. Forty five policies identified in the form of decrees, government regulations, and presidential regulations related to the unmet need for FP. Three themes emerged from the analysis: demand creation, supply side, and socio-demographic factors related to women. In the demand creation, we found varying commitments of the Provincial and District Governments in manage the FP programs. On the supply side, the government guaranteed the availability of contraceptives for all public and private health facilities, as long as they are registered in the BKKBN reporting system. However, there are still problems in distributing contraceptives, especially at the district level to the facilities. The last factors related to the unmet need for FP are the socio-demographic factors, such as fertility and socio-economic factors. In conclusion, at the national level, the policy covered has been adequate to address the demand creation and supply side, but not many about couple factors. The success of FP programs depends on the local government's strong commitment to including the unmet need of FP as their strategic plans
AHP TOPSIS Analysis in Selecting Waste Processing Technology Based on Energy Justice
Authors: Miza Zuda Nurlael  , Rudy Hartanto  , Wing Wahyu Winarno  , Irfan Budi Santoso  
Published: June 2024

The amount of waste in Bantul Regency increased by 4.96% from 2020 to 2021, indicating that the capacity of final disposal sites (FDS) in Piyungan District, Bantul Regency, was decreasing. The peak occurred from 23 July 2023 to 5 September 2023, during which the Piyungan FDS could not provide waste disposal services. The high poverty rate in Bantul Regency forces the government to process waste into energy as a sustainable waste management effort. However, numerous criteria make it difficult to determine which technology is most suitable for this purpose. Energy justice criteria need to be considered when choosing technology and efforts to improve the welfare of Bantul Regency's residents. This research aimed to present an assessment of each alternative technology for processing waste into energy and decide one suitable alternative for sustainable waste management in Bantul Regency using a combination of AHP and TOPSIS methods based on energy justice. AHP was used to assess the level of importance of each criterion, while TOPSIS was used to determine the optimal alternative based on the criteria by considering costs and benefits. The findings showed that the preference value for three alternatives was 0.579, 0.414, and 0.341 for incineration, pyrolysis, and gasification, respectively. According to these preference value, incineration was identified as the foremost viable alternative technology for implementation in Bantul Regency. Gasification and pyrolysis ranked as the subsequent and third alternatives, respectively.
Pengaruh Edukasi Gizi Menggunakan Leaflet dan Video Kementerian Kesehatan terhadap Pengetahuan tentang Isi Piringku pada Anak Usia Sekolah di SDN 21 Sanggalea Kabupaten Maros
Authors: Islam Mar'atul , MB Andi Rahmaniar , Yusuf Kurnia , Masithah St. , Syafruddin Syafruddin 
Published: June 2024

Informasi pendidikan gizi merupakan peran penting dalam kehidupan sehari–hari. Kurangnya pemahaman tentang gizi seimbang dapat menimbulkan berbagai masalah kesehatan dan gizi. Ketidakseimbangan asupan makanan baik gizi kurang maupun gizi berlebih akan menghambat pertumbuhan dan perkembangan manusia yang merupakan salah satu permasalahan yang terjadi. Adapun tujuan untuk mengetahui apakah ada pengaruh pemberian edukasi gizi menggunakan leaflet dan Video Kementerian Kesehatan terhadap pengetahuan tentang Isi Piringku pada anak usia sekolah di SDN 21 Sanggalea Kabupaten Maros.Penelitian ini mengacu pada pendekatan penelitian kuantitatif dengan desain penelitian pre-post test two group design,kelompok intervensi media leaflet dan kelompok pembanding media video. Perbedaan pengetahuan pada media leaflet dan media video yaitu pada media leaflet 11,09 sedangkan pada media video 7,11. Pada nilai median pengetahuan edukasi menggunakan media leaflet yaitu 12,00 dan nilai media yaitu 7,00. Selain itu, nilai Sig. (2-tailed) atau nilai probabilitas dalam Uji Wilcoxon adalah 0.000 Hasil tersebut jika dibandingkan dengan taraf signifikasi 5% (0,05) maka nilai Sig. (2-tailed). Pada hasil uji Wilcoxon Signed Ranks Test didapatkan nilai Sig. (2-tailed) atau nilai probabilitas adalah 0.000. Oleh karena nilai p-value < α (0,05), maka dapat disimpulkan bahwa terdapat pengaruh pengetahuan sebelum dan sesudah diberikan edukasi mengenai isi piringku di SDN 21 Sanggalea Kabupaten Maros.