bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Multiregion Avian Benefits from Strategically Targeted Agricultural Buffers
Authors: EVANS KRISTINE O. , BURGER L. WES , RIFFELL SAM , SMITH MARK D. 
Published: April 2014

AbstractMounting evidence of wildlife population gains from targeted conservation practices has prompted the need to develop and evaluate practices that are integrated into production agriculture systems and targeted toward specific habitat objectives. However, effectiveness of targeted conservation actions across broader landscapes is poorly understood. We evaluated multiregion, multispecies avian densities on row‐crop fields with native grass field margins (i.e., buffers) as part of the first U.S. agricultural conservation practice designed to support habitat and population recovery objectives of a national wildlife conservation initiative. We coordinated breeding season point transect surveys for 6 grassland bird species on 1151 row‐crop fields with and without native grass buffers (9–37 m) in 14 U.S. states (10 ecoregions) from 2006 to 2011. In most regions, breeding season densities of 5 of 6 targeted bird species were greater in the 500‐m surrounding survey points centered on fields with native grass buffers than in landscapes without buffers. Relative effect sizes were greatest for Northern Bobwhite (Colinus virginianus), Dickcissel (Spiza americana), and Field Sparrow (Spizella pusilla) in the Mississippi Alluvial Valley and Eastern Tallgrass Prairie regions. Other species (e.g., Eastern Meadowlark [Sturnella magna], Grasshopper Sparrow [Ammodramus savannarum]) exhibited inconsistent relative effect sizes. Bird densities on fields with and without buffers were greatest in the Central Mixed‐grass Prairie region. Our results suggest that strategic use of conservation buffers in regions with the greatest potential for relative density increases in target species will elicit greater range‐wide population response than diffuse, uninformed, and broadly distributed implementation of buffers. We recommend integrating multiple conservation practices in broader agricultural landscapes to maximize conservation effectiveness for a larger suite of species.Evaluación de los Beneficios de la Mutliregionalidad de Aves a Partir de Amortiguadores Agriculturales Estratégicamente Señalados
Extracorporeal membrane oxygenation: experience in acute graft failure after heart transplantation
Authors: Lehmann Sven , Uhlemann Madlen , Etz Christian D. , Garbade Jens , Schroeter Thomas , Borger Michael , Misfeld Martin , Bittner Hartmuth B. , Mohr Friedrich Wilhelm 
Published: April 2014

AbstractIntroductionAcute graft failure is the leading cause of early mortality after heart transplantation (HTx). Extracorporeal membrane oxygenation (ECMO) is an efficient therapeutic option to treat various pathologies, unburden the left and right ventricle, and allow for functional recovery of the transplanted heart. We reviewed our ECMO experience and outcomes in HTx patients.MethodsRetrospectively, we analyzed all patients who received an orthotopic HTx (n = 298) in our department over a 15‐yr period (1997 through 2011) to assess the incidence of post‐HTx ECMO implantation, perioperative complications, early and one‐yr mortality as well as causes of death.ResultsECMO therapy was utilized to treat graft failure in 28 patients (10.6%) with a mean duration of ECMO support of 4.2 d (six h to 9.4 d). Multivariate analysis revealed as independent predictors for mortality low cardiac output (p = 0.028; odds ratio (OR) = 11.3) and stroke (p = 0.008; OR = 19.7). Cumulative survival rates were 46.4 ± 9.4% within 30 d and 25.0 ± 8.2% at one yr. Causes of death were multiorgan failure (n = 9), sepsis (n = 9), lung failure (n = 2), and intracerebral bleeding (n = 2). ECMO was implanted due to primary graft failure (PGF, n = 16), sepsis (n = 4), and right heart failure (n = 6).ConclusionTemporary ECMO support for postoperative output failure is an acceptable option as a last resort for otherwise doomed patients with fatal graft failure after HTx. The small fraction of patients surviving appear to have a decent long‐term prognosis.
Developmental trajectories of receptive and expressive communication in children and young adults with cerebral palsy
Authors: Vos Rimke C , Dallmeijer Annet J , Verhoef Marjolein , Van Schie Petra E M , Voorman Jeanine M , Wiegerink Diana J H G , Geytenbeek Joke J M , Roebroeck Marij E , Becher Jules G ,   the PERRIN+ Study Group
Published: April 2014

AimThe aim of this study was to determine the developmental trajectories of expressive (speech) and receptive (spoken and written language) communication by type of motor disorder and intellectual disability in individuals with cerebral palsy (CP).MethodThe development of 418 participants (261 males, 157 females; mean age 9y 6mo [SD 6y 2mo], range 1–24y; Gross Motor Function Classification System (GMFCS) level I [n=206], II [n=57], III [n=59], IV [n=54], V [n=42]) was followed for 2 to 4 years in a longitudinal study. Communication performance was measured using the Vineland Adaptive Behavior Scales. The type of motor disorder was differentiated by type of CP as unilateral spastic (USCP, n=161), bilateral spastic (BSCP, n=202), and non‐spastic (NSCP, n=55), while intellectual disability was determined by IQ or school type (regular or special). A multilevel analysis was then used to model the developmental trajectories.ResultsThe most favourable development of expressive communication was seen in USCP (vs BSCP β [SE]‐2.74 [1.06], NSCP β [SE]‐2.67 [1.44]). The difference between the development trajectory levels of children with and without intellectual disability was smaller for children with USCP than for those with BSCP and NSCP. For receptive communication, the most favourable development was found for all children with USCP and for BSCP or NSCP without intellectual disability (vs intellectual disability β [SE]‐4.00 [1.16]). Development of written language was most favourable for children without intellectual disability (vs intellectual disability β [SE]‐23.11 [2.85]).InterpretationThe development of expressive communication was found to be most closely related to type of motor disorder, whereas the development of receptive communication was found to be most closely related to intellectual disability.
The influence of sex on renal function decline in people with Type 2 diabetes
Authors: de Hauteclocque A. , Ragot S. , Slaoui Y. , Gand E. , Miot A. , Sosner P. , Halimi J.‐M. , Zaoui P. , Rigalleau V. , Roussel R. , Saulnier P.‐J. , Hadjadj Samy S. ,   The SURDIAGENE Study group
Published: April 2014

AbstractAimsSeveral reports have suggested a relationship between male sex and albuminuria in Type 2 diabetes, but impact on renal function decline has not been established. Our aim was to describe the influence of sex on renal function decline in Type 2 diabetes.MethodsSURDIAGENE, an inception cohort, consisted in 1470 people with Type 2 diabetes. Patients without renal replacement therapy and with ≥ 3 serum creatinine determinations during follow‐up prior to end‐stage renal disease were included in the study. Estimated glomerular filtration rate was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Primary outcome was steep estimated glomerular filtration rate (eGFR) decline, defined as a yearly slope value lower than –3.5 ml min−1 1.73 m−2. Secondary outcomes were estimated glomerular filtration rate trajectories according to sex and occurrence of end‐stage renal disease.ResultsA total of 22 914 serum creatinine determinations were considered in 1146 participants (60% men), aged 65 ± 11 years, with a median follow‐up duration of 5.7 years (range 0.1–10.2). Median yearly estimated glomerular filtration rate slope was –1.31 ml min−1 1.73 m−2 in women and –1.77 ml min−1 1.73 m−2 in men (P < 0.001). Men were more likely than women to develop end‐stage renal disease (22 men vs. 7 women; Plog‐rank = 0.03). Male sex was an independent risk factor of steep estimated glomerular filtration rate decline [adjusted odds ratio = 1.33 (1.02–1.76), P = 0.04] after adjustment for age, time from diagnosis of Type 2 diabetes, glycated haemoglobin, systolic blood pressure and urinary albumin:creatinine ratio. A multivariable linear mixed‐effects model showed a significant difference of estimated glomerular filtration rate trajectories between men and women (P < 0.001).ConclusionMale sex is an important independent factor associated with renal function decline in Type 2 diabetes.
Residential traffic and incidence of Type 2 diabetes: the German Health Interview and Examination Surveys
Authors: Heidemann C. , Niemann H. , Paprott R. , Du Y. , Rathmann W. , Scheidt‐Nave C. 
Published: April 2014

AbstractAimsTo investigate whether an indicator of overall traffic intensity is related to the risk of Type 2 diabetes in a nationwide cohort.MethodsThe study population comprised 3604 adults aged 18–79 years and without diabetes from the German National Health Interview and Examination Survey (GNHIES98, 1997–1999) who participated again in a follow‐up survey (DEGS1, 2008–2011). The association between the participants' reported traffic intensity at their residential address and Type 2 diabetes incidence was examined using logistic regression models.ResultsDuring a mean of 12.1 years of follow‐up, 252 of the participants included in the study developed Type 2 diabetes. Compared with people living in traffic‐calmed areas, odds ratios were 1.15 (95% CI 0.80–1.67) for people living on moderately busy side streets, 1.11 (95% CI 0.69–1.80) for people living on considerably busy side streets, 1.41 (95% CI 0.96–2.08) for people living on heavily busy roads, and 1.97 (95% CI 1.07–3.64) for people living on extremely busy roads, after adjusting for age, sex, active and passive smoking, type of heating, education, BMI, waist circumference, sport activity and parental diabetes history.ConclusionsThe twofold higher risk of Type 2 diabetes observed for people exposed to intense traffic in this nationwide cohort extends the limited evidence from previous selected populations. Although the underlying traffic‐related components and their biological mechanisms still need to be unravelled, traffic exposure control should be considered in public health strategies to reduce the global burden of diabetes.
Effects of an inpatient rehabilitation program after temporal lobe epilepsy surgery and other factors on employment 2 years after epilepsy surgery
Authors: Thorbecke Rupprecht , May Theodor W. , Koch‐Stoecker Steffi , Ebner Alois , Bien Christian G. , Specht Ulrich 
Published: April 2014

SummaryObjectiveTo evaluate the effects of a postsurgical rehabilitation program on employment status 2 years after temporal lobe epilepsy surgery in relation to other predictors.MethodsEmployment outcome 2 years after temporal lobe resection in a group of 232 adult patients with the offer of a 3‐week inpatient rehabilitation program immediately after surgery (“Reha group”) was compared to a group of 119 patients who had surgery before such a rehabilitation program existed. One hundred thirty‐nine (59.9%) of the Reha group patients attended the rehabilitation program. Further predictors for employment outcome were analyzed using multivariate logistic regression analysis.ResultsPreoperatively, the groups did not differ significantly in variables relevant for employment, including employment rate. Two years after surgery, the rate of those not being employed had decreased in the Reha group from 38.4% to 27.6% (p < 0.001, McNemar test), and slightly increased in the control group (37.8–42.0%; n.s.), resulting in a difference of 14.4% in favor of the Reha group (p = 0.008). General unemployment rates during the two observation periods were similar. In addition to the offer of rehabilitation support (“Reha group”) and preoperative employment, the following other variables were shown as significant predictors of employment post surgery in multivariate regression analysis: seizure outcome, diagnosis of a personality disorder preoperatively, and age at surgery (all, p < 0.01; Nagelkerkes R2 = 0.59).SignificanceIndependently from other factors, a 3‐week inpatient rehabilitation program after temporal lobe epilepsy surgery seems to improve employment status 2 years after surgery.A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.
Recurrent generalized seizures, visual loss, and palinopsia as phenotypic features of neuronal ceroid lipofuscinosis due to progranulin gene mutation
Authors: Canafoglia Laura , Morbin Michela , Scaioli Vidmer , Pareyson Davide , D'Incerti Ludovico , Fugnanesi Valeria , Tagliavini Fabrizio , Berkovic Samuel F. , Franceschetti Silvana 
Published: April 2014

SummaryWe detail the phenotype of a novel form of neuronal ceroid lipofuscinosis due to a homozygous progranulin gene mutation (c.813_816del; CLN11 MIM #614706). The symptoms appeared in two young adult siblings, and included progressive retinopathy, recurrent generalized seizures, moderate ataxia, and subtle cognitive dysfunction. Long‐lasting episodes of palinopsia were a recurring symptom and associated with polyphasic visual‐evoked potential waveform that suggested hyperexcitability of the occipital cortex. Electroencephalography showed rare spike‐wave paroxysms, and magnetic resonance imaging revealed selective cerebellar atrophy. Skin biopsy revealed fingerprint storage and the absence of progranulin protein. Electron microscopy of peripheral blood leukocytes showed fingerprint profiles in 1/100 lymphocytes. These findings define a novel phenotype and provide clues for better understanding of progranulin function.A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.
Role of integrin signalling through integrin‐linked kinase in skin physiology and pathology
Authors: Eckes Beate , Krieg Thomas , Wickström Sara A. 
Published: April 2014

AbstractCell–matrix adhesions provide structural stability to the tissue and regulate intracellular signalling pathways that are important for cell fate decisions of the different cell populations within the skin. As a consequence of these central functions, genetic or functional impairment of various key protein components of matrix adhesions plays a causative role in the aetiology or pathophysiology in a large variety of skin disorders. Research towards understanding the molecular composition of these adhesions as well as the mechanisms by which they transmit signals is therefore of obvious importance. In this essay, we discuss the roles of integrin‐linked kinase, a key component of cell–matrix adhesions, in the (patho)physiology of skin and in particular highlight its role in regulating mechanical tension and matrix remodelling both in the epidermis and in the dermis.
Comparative study of Hsp27, GSK3β, Wnt1 and PRDX3 in Hirschsprung's disease
Authors: Gao Hong , Liu Xiaomei , Chen Dong , Lv Liangying , Wu Mei , Mi Jie , Wang Weilin 
Published: April 2014

SummaryHirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system characterized by aganglionosis in distal gut. In this study, we used two‐dimensional gel electrophoresis (2‐DE) technology coupled with matrix assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF‐MS) analysis to identify differentially expressed proteins in the aganglionic (stenotic) and ganglionic (normal) colon segment tissues from patients with HSCR. We identified 15 proteins with different expression levels between the stenotic and the normal colon segment tissues from patients with HSCR. Nine proteins were upregulated and six proteins downregulated in the stenotic colon segment tissues compared to the normal colon segment tissues. Based on the biological functions, we selected the Hsp27 upregulated proteins and the PRDX3 downregulated proteins to confirm their expression in 20 patients. The protein and mRNA expressions of Hsp27 were statistically higher in the stenotic colon segment tissues than in the normal colon segment tissues, whereas the protein and mRNA expressions of PRDX3 were statistically lower in the stenotic colon segment tissues than in the normal colon segment tissues. These findings of changes in mRNA and protein in tissues from patients with HSCR provide information which may be helpful in understanding the pathomechanism that is implicated in the disease.
A novel KIR3DS1*0130107 allele isolated by sequencing from an Asian donor
Authors: Yindom L.‐M. , Wang L. , Xu K. , Dong T. , Rowland‐Jones S. L. 
Published: April 2014

SummaryThis novel KIR3DS1 allele officially named as KIR3DS1*0130107 was isolated from DNA samples from Asia using high‐resolution sequenced‐based techniques. KIR3DS1*0130107 differs from the first member of the KIR3DS1*013 subgroup (KIR3DS1*0130101) by a single mutation at position 8922A>G (intron 5), just nine nucleotides away from the start of exon 6.
Clinical and Radiological Heterogeneity in Aneurysmal Sub-Arachnoid Haemorrhage According to Risk-Factor Profile
Authors: Nieuwkamp Dennis J. , Algra Ale , Velthuis Birgitta K. , Rinkel Gabriël J.E. 
Published: April 2014

Background and Aim Risk factors for aneurysmal sub-arachnoid haemorrhage can be divided into environmental and inherited factors; the latter being presumed more important in young patients. We explored in young sub-arachnoid haemorrhage patients whether risk-factor profiles influence clinical and radiological characteristics of aneurysms and sub-arachnoid haemorrhage. Methods From the 2139 aneurysmal sub-arachnoid haemorrhage patients who had been entered in our prospectively collected database between January 1997 and August 2012, we retrieved data on young (18–40 years) aneurysmal sub-arachnoid haemorrhage patients and compared those with smoking or hypertension (atherogenic risk factors) with those without. Clinical and radiological characteristics were compared with risk ratios and corresponding 95% confidence intervals. Possible confounding by age and gender was adjusted with multivariable Poisson regression analysis. Results Patients with atherogenic risk factors ( n = 113) were less often female (risk ratio: 0·7; 95% confidence interval: 0·6↔0·9), had less often a small aneurysm (risk ratio: 0·4; 95% confidence interval: 0·2↔0·7), and tended to have less often middle cerebral artery aneurysms (risk ratio: 0·5; 95% confidence interval: 0·3↔1·1) than the 29 patients without these risk factors. After adjustment for gender and age, patients with atherogenic risk factors had more often multiple aneurysms (risk ratio: 7·5; 95% confidence interval: 1·1↔52·9). There were no overt differences in the amount of cisternal and intraventricular blood, the shape of the aneurysm, and configuration of the circle of Willis between the patient groups. After adjustment for gender and age, patients with atherogenic risk factors had more often poor outcome (risk ratio: 3·8; 95% confidence interval: 1·0↔14·5). Conclusions Young sub-arachnoid haemorrhage patients without atherogenic risk factors are rare. Clinical and radiological characteristics vary between sub-arachnoid haemorrhage patients with different risk-factor profiles. This clinical heterogeneity should be taken into account in future genetic and other etiological studies.
Effects of Mild and Severe Drought Stress on Photosynthetic Efficiency in Tolerant and Susceptible Barley (Hordeum vulgare L.) Genotypes
Authors: Ghotbi‐Ravandi A. A. , Shahbazi M. , Shariati M. , Mulo P. 
Published: April 2014

AbstractDrought stress is one of the most important abiotic factors which adversely affect growth, metabolism and yield of crops worldwide. The objective of this study was to determine the effects of drought stress on photosynthesis in barley and examine the differential responses of photosynthetic apparatus in relatively tolerant (Yousof) and susceptible (Morocco) barley genotypes. Plants were subjected to different levels of soil water availability including control, mild and severe drought stress. In both genotypes, drought stress led to decrease in chlorophylls, β‐carotene and stomatal conductance accompanied by decrease in CO2 assimilation rate. Significant increase in α‐tochoperol content was only observed in Yousof cultivar under drought stress. Initial slope and plateau phase of CO2 response curve of drought‐stressed plants as well as polyphasic chlorophyll a fluorescence transient curve (OJIP test) and fast fluorescence induction kinetics were influenced by drought stress. These parameters were more affected in Morocco cultivar by drought stress compare with Yousof. Drought stress also resulted in reduction of D1 protein content in both genotypes and accelerated photoinhibition process. Based on our results, stomatal conductance is the main factor limiting photosynthesis in Yousof genotype under mild drought stress. However, in Morocco, in addition to stomatal limitation, damage to photosystem II (PSII), reduced electron transport and carboxylation efficiencies were important parts of limitation in photosynthesis. Severe drought stress resulted in structural and biochemical impairment of light‐dependent reactions as well as carboxylation process of photosynthesis in both genotypes. Alpha‐tocopherol showed an important protective role against drought stress in Yousof cultivar as a relatively drought‐tolerant cultivar.
Antioxidant Activity in Salt‐Stressed Barley Leaves: Evaluating Time‐ and Age‐Dependence and Suitability for the Use as a Biochemical Marker in Breeding Programs
Authors: Fan Y. , Zhu M. , Shabala S. , Li C. D. , Johnson P. , Zhou M. X. 
Published: April 2014

AbstractSoil salinity disturbs the equilibrium between reactive oxygen species (ROS) production and removal, leading to a dramatic increase in ROS concentration and oxidative damage. Enzymatic scavenging is one of the two main mechanisms involved in ROS detoxification in plants. This study has investigated the role of major antioxidant (AO) enzymes in mitigating salinity‐induced oxidative stress in plant shoots. Firstly, two barley varieties were used to evaluate the activity of major AO enzymes in different leaves and at different times after salt treatment. Our results showed that AO enzyme activities had strong tissue and time specificity. A further study was conducted using six barley varieties contrasting in salinity tolerance. AO enzyme activities and proline contents were measured in the third leaves of seedlings after plants were treated with 240 mm NaCl for 10 days. No significant correlation was revealed between leaf AO activity and either plant grain yield or plant survival rate under salt stress. In contrast, a significant increase in leaf proline content under salt stress was found in all sensitive varieties, while in most tolerant varieties, salt stress did not change leaf proline level. It is concluded that although salinity induces changes in leaf AO enzyme activities, the changes cannot be used as biochemical indicators in breeding for salinity tolerance.