bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone mass density selectively correlates with serum markers of oxidative damage in post-menopausal women
Authors: Cervellati Carlo , Bonaccorsi Gloria , Cremonini Eleonora , Bergamini Carlo M. , Patella Alfredo , Castaldini Cristina , Ferrazzini Stefania , Capatti Alessandra , Picarelli Venelia , Pansini Francesco S. , Massari Leo 
Published: September 2012

Abstract

Background: Post-menopausal osteoporosis (PO) affecting a large fraction of elderly women, is triggered by the decline in 17β-estradiol (E2) level. Experimental studies in animal models and cell cultures have suggested that the fall in E2 might contribute to developing oxidative stress (OS) which in turn is believed to play an important role in PO pathogenesis. The scarcity of human studies focusing on this issue prompted us to investigate the effects of the reproductive and post-reproductive phase of women’s life on OS and bone health.

Methods: Serum parameters of oxidative challenge (lipid hydroperoxides and protein advanced oxidation products) and antioxidant defence (total serum antioxidants levels) along with bone mineral density (BMD) at femoral neck and lumbar spine were assessed in a sample of 191 women (98 pre- and 93 post-menopausal, of whom 30 osteoporotic).

Results: Pearson’s correlation analysis unveiled that spinal BMD was negatively correlated with lipid hydroperoxides in overall postmenopausal subsample (r=–0.251, p=0.012), while no significant link between these two variables was detected in women in reproductive age (r=–0.022, p=0.833). Noteworthy, stepwise multiple regression analysis showed that the association found in post-menopausal women retained significance after adjusting for potential confounding factors (p=0.001).

Conclusions: Our data showed that markers of oxidative challenge are associated with bone loss in women in post-menopausal status. We suggest that menopause-related estrogen withdrawal might contribute to make bone more vulnerable to oxidative injury thereby increasing the risk of PO development.
Improvement of a prenatal screening program for trisomy 18 in the first trimester of gestation
Authors: Martínez-Morillo Eduardo , Prieto Belén , Moreno Francisco , Álvarez Francisco V. 
Published: September 2012

Abstract

Background: The aim of this study was to evaluate population parameters (medians, standard deviations and coefficients of correlation) different from those used by the commercial software Elipse® v3.0 (Perkin Elmer) in the calculation of prenatal risk of trisomy 18. Moreover, the truncation limits used for extreme values of free β-human chorionic gonadotropin (fβ-hCG), pregnancy associated plasma protein-A (PAPP-A) and nuchal translucency (NT) were revised.

Methods: A calculation engine for the prenatal risk of trisomy 18 was developed [called FMF (Fetal Medicine Foundation) calculator]. Recently, published population parameters for fβ-hCG and PAPP-A as well as new truncation limits were included in this calculator. The patient-specific risks obtained by Elipse® v3.0 and FMF calculators, were compared in 18,801 pregnant women, including 13 cases of trisomy 18, four cases of trisomy 13 and one case of triploidy.

Results: Using a cut-off point of 1:250, FMF calculator increased the detection rate of trisomy 18 from 62% to 100% with a 0.31% increase in the false-positive rate (FPR). When the detection rate was fixed at 100%, the FPR generated by Elipse v3.0 (1.52%) was significantly higher (p<0.0001) than that generated by the FMF calculator (0.36%). Moreover, an improved detection in cases of trisomy 13 and triploidy was observed.

Conclusions: It is recommended that each laboratory reviews the population parameters and truncation limits used in the risk calculation of trisomy 18, in order to obtain an adequate performance in the screening.
Prepare(d) for Impact: PV Cost Reduction and Beyond
Authors: Wim C. Sinke 
Published: September 2012

AbstractPhotovoltaic solar energy technology (PV) may reach the terawatt deployment scale within a decade. This is enabled by rapid cost reduction through which PV is able to compete with conventional power in an increasing fraction of electricity markets globally. Although further cost reduction is essential for very large scale deployment and requires dedicated research and development efforts, it is not sufficient. Availability of fully sustainable technology and (electrical & physical) integration are other necessary ingredients for multi-terawatt-scale use. This paper quantifies and discusses the development challenges of PV and reviews some of the recent publications addressing the future of PV.
Acute myocardial infarction (AMI) (n-11026) on days of zero geomagnetic activity (GMA) and the following week: differences at months of maximal and minimal solar activity (SA) in solar cycles 23 and 24
Authors: Stoupel Eliyahu , Tamoshiunas Abdonas , Radishauskas Richardas , Bernotiene Gailute , Abramson Evgeny , Israelevich Peter 
Published: September 2012

Abstract

Background: Acute myocardial infarction (AMI) is one of most common cardiovascular pathologies in the industrial world. In addition to known risk factors, environmental physical activity factors such as solar activity (SA), geomagnetic activity (GMA), and cosmic ray activity (CRA) could be also involved in the timing of AMI. The aim of this study was to study AMI admissions at days of zero GMA, accompanied by high CRA, and the following week in the higher and lowest parts of solar cycles 23 and 24.

Methods: Patients admitted for AMI (n=11,026, 59.5% men) in years 2000–2009 at the Department of Cardiology of Lithuanian University of Medical Sciences were studied for all periods and separately for the higher part of the 11-year solar activity in cycles 23 and 24 (2000–2007) and its lowest part (2008–2009). Admissions at day of zero GMA as well as 1, 2, 6, and 7 days after zero-GMA day were compared.

Results: At high SA, zero-GMA days were rare and isolated (36 in years 2000–2007). They have been followed by significant increase in admissions on the following days. In the two lowest years of SA 2008–2009, there were 57 days of zero GMA, many of which were consecutive and in groups. For the whole solar cycle, there was a more gradual increase in AMI from 1 to 2 days after zero-GMA day, and there were significantly higher AMI admissions at 6 days after the first zero-GMA day (p=0.018).

Conclusions: Zero-GMA/high-neutron activity is followed by increase in AMI admissions at the days that follow. The effects are different at high and low parts of the 11-year solar cycle.
Crystal structure of (2R, 3R, 4S)-5-dibromomethyl-3,4-dihydro-3,4- dihydroxy-3,4-O-isopropylidene-2-(N-succinimido)-2H-pyrrole-1-oxide, C12H14Br2N2O5
Authors: Frey Wolfgang , Castiglia Amélie , Jäger Volker 
Published: September 2012

AbstractC12H14Br2N2O5, orthorhombic, P212121(no. 19), a = 5.7982(4) Å, b = 8.5837(6) Å, c = 29.676(2) Å, V = 1477.0 Å3, Z = 4, Rgt(F) = 0.0558, wRref(F2) = 0.1248, T = 100 K.
Crystal structure of 2-[(3-bromo-phenylimino)-methyl]-4-chloro-phenol, C13H9BrClNO
Authors: Zhang Xin-Li 
Published: September 2012

Abstract
C13H9BrClNO, monoclinic, Pc (no. 7), a = 10.929(4) Å, b = 4.3884(16) Å, c = 12.267(5) Å, β = 95.920(7)° V = 585.2(4)Å3, Z = 2, Rgt(F) = 0.039, wRref(F2) = 0.075, T = 153(2)K
Crystal structure of ethanediammonium 3,4,5,6-tetrabromo-2-(ethoxy carbonyl)benzoate hydrate, (C2H10N2)(C10H5Br4O4)2·2H2O, C22H24Br8N2O10
Authors: Li Jian 
Published: September 2012

Abstract
C11H12Br4NO5, monoclinic, P21/c (no. 14), a = 17.724(2) Å, b = 11.718(1) Å, c = 8.1510(7) Å, β = 100.655(1)°, V = 1663.7 Å3, Z = 4,Rgt(F) = 0.0471, wRref(F2) = 0.0961, T = 298 K.
Crystal structure of 2,2'-bipyridino-tetrafluorophthalato-copper(II) [Cu(C8HF4O4)(C10H8N2)2](C8H2F4O4)(C8HF4O4), C44H20CuF12N4O12
Authors: Zhang Jun , Liu Yuan-Ying , Ying Kun 
Published: September 2012

Abstract
C44H20CuF12N4O12, triclinic, P1̄ (no. 2), a = 12.274(1) Å, b = 14.621(3) Å, c = 14.623(2) Å, α = 104.891(2)°, β = 109.986(1)°, γ = 106.783(2)°, V = 2169.0 Å3, Z = 2, Rgt(F) = 0.0566, wRref(F2) = 0.1697, T = 296 K.
Crystal structure of 3-acetoxy-16-bromo-17-ethylenedioxyandrost-5-ene, C23H33BrO4
Authors: Xu Jia-Ying , Cheng Wei-Hua 
Published: September 2012

Abstract
C23H33BrO4, monoclinic, C2 (no. 5), a = 10.314(2) Å, b = 7.590(2) Å, c = 28.312(6) Å, β = 99.79(3)°, V = 2184.1 Å3, Z = 4, Rgt(F) = 0.0670, wRref(F2) = 0.1446, T = 293 K.
Crystal structure of (pyridine-2-carboxamide-N,O)[tris-(2-aminoethyl) amine-N,N',N'',N''']nickel(II) diperchlorate-monohydrate, [Ni(C6H18N4)(C6H6ON2)][ClO4]2·H2O, C12H26Cl2N6NiO10
Authors: Zhang Xin , Nie Feng-Mei 
Published: September 2012

Abstract
C12H26Cl2N6NiO10, orthorhombic, Pbca ( no. 61 ) , a = 12.295(3) Å, b = 11.377(2) Å, c = 30.245(6) Å, V = 4230.7 Å3, Z = 8, Rgt(F) = 0.0535, wRref(F2) = 0.1394, T = 153 K.
Crystal structure of 1,5-dimethyl-4-[(3-indoleyl)-methyleneamino]-2- phenyl-1H-pyrazol-3(2H)-one, C20H18N4O
Authors: Wang Jun-Ling , Ma Jun-Ying , Bai Zheng-Hui , Lin Hua 
Published: September 2012

Abstract
C20H18N4O, orthorhombic, P212121 (no. 19), a = 6.8679(8) Å, b = 15.768(2) Å, c = 16.498(2) Å, V = 1786.6 Å3, Z = 4, Rgt(F) = 0.0362, wRref(F2) = 0.0899, T = 296 K.
Fabrication of superhydrophobic surface of stearic acid grafted zinc by using an aqueous plasma etching technique
Authors: Gao Jinzhang , Li Yaping , Li Yan , Liu Hongwei , Yang Wu 
Published: September 2012

Abstract
A stable superhydrophobic surface of stearic acid grafted zinc was fabricated with two steps, that is, the zinc surface was firstly treated with glow discharge electrolysis plasma (GDEP) and then followed by a grafted reaction of stearic acid onto the treated zinc surface. Results indicated that the wettability of zinc substrate changed from superhydrophily to superhyphodrobicity with a water contact angle (CA) up to 158° and a water sliding angle (SA) less than 5°. The surface morphology and composition were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively.
Extraction properties of β-aminophosphine oxides towards lanthanides and alkaline earth metals
Authors: Matveeva Ekaterina , Sharova Elena , Turanov Alexander , Karandashev Vasilii , Odinets Irina 
Published: September 2012

Abstract
The investigation of the extraction properties of a series of polyoligodentate β-aminophosphine oxides 1–8 bearing from one to six phosphine oxide groups in a molecule towards Ln(III) and alkaline earth metals ions from neutral media has revealed that, using common diluents, the extraction efficiency increases with an increase of a number of P=O functions in a ligand. The addition of ionic liquid, namely 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([bmim][NTf2]), significantly increasing the extraction efficiency and application of IL concentration of 0.05 M (in 1,2-dichloroethane) providing the maximum recovery of metal ions with Lu/La separation factor reaching up to 91. Hexapodal tris[bis(2-diphenylphosphorylethyl)aminoethyl]amine 8 demonstrates the highest extraction under all conditions applied and the separation factor for U and Eu of this compound exceeded 103.
A concise synthesis of enantiomerically pure aroyl-l-alanines and dihydroaroyl-l-alanines
Authors: Gardiánová Mária , Slížik Ľuboš , Koreňová Anna , Považanec František , Berkeš Dušan 
Published: September 2012

AbstractStraightforward preparation of enantiomerically highly enriched N-substituted aroylalanines has been developed. This process involves the combination of crystallization-induced asymmetric transformation and a conjugate addition of N-nucleophiles to the corresponding aroylacrylic acids. Further transformations to 3,4-dichlorobenzoylalanine and aroyl-l-alanines via periodate oxidation and stereoselective reduction to N-substituted syn-4-aryl-4-hydroxy-2-aminobutanoic acids are also described.
Spectral characterisation of new organic fluorescent dyes with an alkoxysilane moiety and their utilisation for the labelling of layered silicates
Authors: Danko Martin , Mičušík Matej , Omastová Mária , Bujdák Juraj , Chorvát Dušan 
Published: September 2012

AbstractNew fluorescence dyes with an alkoxysilane moiety were synthesised by the condensation of 3-(triethoxysilyl)-1-propanamine (3-aminopropyltriethoxysilane) with 4,10-benzothioxanthene-3,1′-dicarboxylic acid anhydride (BTXA) and N,N-dimethylaminonaphthalene-1,8-dicarboxylic acid anhydride (DMANA), which was accompanied by the formation of an imidic bridge. The compounds N-(3-(triethoxysilyl)propyl)-thioxantheno[2,1,9-dej]isoquinoline-1,3-dione (BTX-S) and 4-(N′, N′-dimethyl)-N-(triethoxysilyl)propyl-1,8-naphthalene dicarboxylic acid imide (DMAN-S) were characterised by steady-state and time-resolved fluorescence spectroscopy in chloroform and ethanol. Both conjugates (BTX-S and DMAN-S) exhibited absorption and emission bands in the same region as the un-substituted BTXA and DMANA. An important Stokes shift was observed for DMAN-S in ethanol. A high fluorescence quantum yield was observed for BTX-S in both solvents and for DMAN-S in chloroform. In addition, the newly developed fluorescent silane dyes were covalently attached to the microscopic particles of layered silicates and on the surface of SiO2 wafers as a proof of concept for fluorescence particle (surface) visualisation. The surface wafer modification was precisely characterised by X-ray photoelectron spectroscopy (XPS). Successful covalent linkage onto the particles of layered silicates was proved by confocal laser scanning microscopy technique.
Conjugated push-pull salts derived from linear benzobisthiazole: preparation and optical properties
Authors: Čibová Alexandra , Magdolen Peter , Fülöpová Andrea , Zahradník Pavol 
Published: September 2012

AbstractA series of novel monomethylated salts derived from linear benzobisthiazole was prepared. The push-pull attributes of these new compounds are represented by a quaternised azolium cycle as the acceptor part at one end of the structure and the dialkylamino- or diarylamino-substituted benzene ring as the donor part at the opposite end. Both moieties are connected by a conjugated linker consisting of one or two double bonds. Such dipolar structures are promising candidates for non-linear optical materials. The quantum-chemical indices describing linear and non-linear optical properties were obtained from semi-empirical calculations. The relationships between the chemical structure and non-linear optical properties of the cations studied were obtained. Effective conjugation was confirmed by measuring the optical properties in the UV-VIS region.
Comparison of the 2010 American College of Rheumatology/European League Against Rheumatism and the 1987 American Rheumatism Association Classification Criteria for Rheumatoid Arthritis in an Early Arthritis Cohort in New Zealand
Authors: RAJA RAFI , CHAPMAN PETER T. , O’DONNELL JOHN L. , IPENBURG JAN , FRAMPTON CHRIS , HURST MIRIAM , STAMP LISA K. 
Published: September 2012

Objective.To compare the performance of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria with the 1987 American Rheumatism Association (ARA) criteria for rheumatoid arthritis (RA) in an early arthritis cohort.Methods.The study included 79 patients with early arthritis (symptoms < 12 months) and a minimum of 1 year of followup between January 2004 and August 2010. Case notes were reviewed to determine which criteria were fulfilled at initial, 3-month, 1-year, and 2-year visits. Requirements for disease-modifying antirheumatic drug (DMARD) therapy and presence of joint erosions were compared at 2 years.Results.At the initial visit, twice as many patients fulfilled the 2010 criteria (67%) compared with the 1987 criteria (34%; p < 0.001). Forty-four percent of patients who fulfilled only the 2010 criteria at the initial visit went on to fulfill both 1987 and 2010 criteria at 3 months (p < 0.001). Eight patients did not meet the 1987 RA criteria solely because of short symptom duration. All 17/79 patients who developed joint erosions went on to eventually fulfill both criteria. Of those patients who fulfilled only the 2010 criteria at baseline, 25/27 (93%) ultimately received DMARD therapy compared with 24/26 (92%) of those fulfilling both 1987 and 2010 criteria.Conclusion.The 2010 ACR/EULAR RA criteria allowed earlier RA classification compared to the 1987 ARA criteria, although both criteria were equivalent in predicting joint erosions and subsequent need for DMARD (Australian New Zealand Clinical Trials Registry ANZCTR 12608000292370).
The Belgian Systemic Sclerosis Cohort: Correlations Between Disease Severity Scores, Cutaneous Subsets, and Autoantibody Profile
Authors: VANTHUYNE MARIE , SMITH VANESSA , DE LANGHE ELLEN , VAN PRAET JENS , ARAT SEHER , DEPRESSEUX GENEVIÈVE , WESTHOVENS RENE , BLOCKMANS DANIEL , BADOT VALÉRIE , COGAN ELIE , DE KEYSER FILIP , HOUSSIAU FRÉDÉRIC A. 
Published: September 2012

Objective.To report baseline and followup data on the first 438 patients with systemic sclerosis (SSc) included in the Belgian Systemic Sclerosis Cohort.Methods.According to LeRoy and Medsger’s classification, 73 patients with limited SSc (lSSc), 279 with limited cutaneous SSc (lcSSc), and 86 with diffuse cutaneous SSc (dcSSc) were included. History was collected and clinical examination, blood tests, and paraclinical investigations were repeated. The Disease Activity Score (DAS) and Disease Severity Score (DSS) of several organ systems were computed. An organ system was considered to demonstrate SSc if the corresponding DSS was ≥ 1.Results.At baseline, patients with dcSSc had more general, joint/tendon, muscle, gastrointestinal, and kidney involvement. Mean DLCO was below normal in patients with lSSc, indicating unsuspected lung involvement. Patients with anti-Scl-70 had more vascular, skin, joint/tendon, and lung involvement. Patients with anti-RNA polymerase III had more skin and joint/tendon involvement compared to patients with anticentromere. Time to death was statistically shorter for patients with dcSSc. New-onset lung disease was the most common complication over time. No changes in DAS were observed. By contrast, the general and the skin DSS worsened in patients with lcSSc and lSSc, respectively. Fifteen percent of patients with lSSc shifted to lcSSc at Month 30, but neither serology nor capillaroscopy findings at baseline were helpful in identifying those at risk.Conclusion.Our data indicate that the DSS can be used to define organ involvement in SSc. Differences can be seen between subsets classified not only according to cutaneous subtypes but also to autoantibody profile.
Incidence of Spondyloarthropathy in Patients with Crohn’s Disease: A Population-based Study
Authors: SHIVASHANKAR RAINA , LOFTUS EDWARD V. , TREMAINE WILLIAM J. , BONGARTZ TIM , HARMSEN W. SCOTT , ZINSMEISTER ALAN R. , MATTESON ERIC L. 
Published: September 2012

Objective.Spondyloarthritis (SpA) is an extraintestinal manifestation of inflammatory bowel disease with significant clinical effects, although the frequency is uncertain. We assessed the cumulative incidence and clinical spectrum of SpA in patients with Crohn’s disease (CD) in a population-based cohort.Methods.The medical records of a population-based cohort of Olmsted County, Minnesota, residents diagnosed with CD between 1970 and 2004 were reviewed. Patients were followed longitudinally until migration, death, or December 31, 2010. We used the European Spondylarthropathy Study Group, Assessment of Spondyloarthritis international Society (ASAS) criteria and modified New York criteria to identify patients with SpA. The Kaplan-Meier method was used to estimate the cumulative incidence of SpA following diagnosis of CD.Results.The cohort included 311 patients with CD (49.8% females; median age 29.9 yrs, range 8–89). Thirty-two patients developed SpA based on ASAS criteria. The cumulative incidence of SpA after CD diagnosis was 6.7% (95% CI 2.5%–6.7%) at 10 years, 13.9% (95% CI 8.7%–18.8%) at 20 years, and 18.6% (95% CI 11.0%–25.5%) at 30 years. The 10-year cumulative incidence of ankylosing spondylitis was 0, while both the 20-year and 30-year cumulative incidences were 0.5% (95% CI 0–1.6%).Conclusion.We have for the first time defined the actual cumulative incidence of SpA in CD using complete medical record information in a population-based cohort. The cumulative incidence of all forms of SpA increased to approximately 19% by 30 years from diagnosis of CD. Our results emphasize the importance of maintaining a high level of suspicion for SpA when following patients with CD.
Prospective Study of Clinical Phenotypes in Neuropsychiatric Systemic Lupus Erythematosus; Multidisciplinary Approach to Diagnosis and Therapy
Authors: ZIRKZEE ELISABETH J.M. , STEUP-BEEKMAN GERDA M. , van der MAST ROOS C. , BOLLEN EDUARD L.E.M. , van der WEE NIC J.A. , BAPTIST ESTHER , SLEE THOMAS M. , HUISMAN MENNO V. , MIDDELKOOP HUUB A.M. , LUYENDIJK JASPER , van BUCHEM MARK A. , HUIZINGA TOM W.J. 
Published: September 2012

Objective.To describe clinical phenotypes in neuropsychiatric systemic lupus erythematosus (NPSLE).Methods.Data were prospectively collected in the Leiden NPSLE referral clinic, where patients suspected of having NPSLE are assessed in a standardized multidisciplinary manner. In consensus meetings, all medical specialists agreed on therapeutic strategy based on the suspected pathogenetic mechanism of NPSLE in the individual patient. An algorithm illustrates the process of decision-making during the consensus meeting. Clinical phenotypes are described, classified by pathogenetic mechanism.Results.One hundred consecutive patients were evaluated, of whom 71 had SLE (29 patients did not fulfill ≥ 4 American College of Rheumatology criteria) and 46 had NPSLE. Primary NPSLE was diagnosed in 38 patients (53%) and could be differentiated in 21 patients (55%) with inflammatory NPSLE who were advised on immunosuppressive therapy, 12 patients (32%) with ischemic NPSLE who were advised on anticoagulant therapy, and 5 patients (13%) with undefined NPSLE who were advised symptomatic treatment only. Cognitive dysfunction and higher level of disease activity were associated with inflammatory NPSLE. Although presence of immunoglobulin G anticardiolipin antibodies and abnormalities on magnetic resonance imaging (MRI) were associated with ischemic NPSLE, abnormalities on MRI lacked specificity to distinguish phenotypes. A history of renal disease and use of corticosteroids were associated with secondary NPSLE.Conclusion.We describe multidisciplinary consensus as a standard for diagnosing and defining phenotypes in NPSLE. These phenotypes show specific characteristics, which can be used to support diagnosis and guide therapeutic decisions. Clinical phenotyping and selection of patients becomes increasingly important when advances in experimental science lead to new targets for therapy in NPSLE.