bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for Anxiety Symptoms in Parkinson Disease
Authors: Stefanova Elka , Ziropadja Ljubomir , Petrović Mirjana , Stojković Tanja , Kostić Vladimir 
Published: February 2013

Background: A limited number of studies examined anxiety in Parkinson disease (PD). Questionable validity of the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) defined anxiety disorders in PD population as well as a lack of validated rating scales hampered the investigation in this field. Objective: To screen for prevalence of anxiety symptoms and their associated demographic and clinical features in an outpatient-based cohort with PD. Patients and methods: A consecutive series of 360 patients with PD underwent investigation with the Hamilton Anxiety Rating Scale (HARS), the 17-item Hamilton Depression Rating Scale, Neuropsychiatric Inventory, section E (anxiety), motor scoring with Hoehn and Yahr staging, the Unified Parkinson’s Disease Rating Scale, and cognitive screening with the Mini-Mental State Examination. Results: In all, 136 (37.8%) patients with PD of our cohort had anxiety symptoms, whereas both depression and anxiety were recorded in 5.6% of the patients, while in 56.7% neither anxiety nor depression was present. Female gender, motor disability, and core depression symptoms were the main markers of anxiety in patients with PD. The severity of anxiety symptoms was not associated with asymmetry of motor symptoms. Education, disease duration, and levodopa dose were poor predictors in the model. The HARS had a satisfactory inter-item correlation, convergent validity, and factorial structure. Conclusions: Anxiety may be present as an isolated symptom, with specific demographic and clinical markers, and not only as a feature of depression in PD population. This highlighted the importance of identifying anxiety symptoms when treating patients with PD.
AAFP and ISFM Feline Environmental Needs Guidelines
Authors: Ellis Sarah L H , Rodan Ilona , Carney Hazel C , Heath Sarah , Rochlitz Irene , Shearburn Lorinda D , Sundahl Eliza , Westropp Jodi L 
Published: February 2013

Guidelines rationale: A cat’s level of comfort with its environment is intrinsically linked to its physical health, emotional wellbeing and behavior. Having a basic understanding of the cat’s species-specific environmental needs and how cats interact with their environment will provide a foundation for addressing these fundamental requirements. Environmental needs: Addressing environmental needs is essential (not optional) for optimum wellbeing of the cat. Environmental needs include those relating not only to the cat’s physical surroundings (indoors or outdoors; in the home environment or at the veterinary practice) but also those affecting social interaction, including responses to human contact. Five ‘pillars’ framework: The authorship panel has organized the Guidelines around five primary concepts (‘pillars’) that provide the framework for a healthy feline environment. Understanding these principles and the unique environmental needs of the cat will help veterinarians, cat owners and care-givers to reduce stress, the incidence of stress-related disorders, and unwanted behavior in their feline patients and pets. The recommendations in the Guidelines apply to all pet cats, regardless of lifestyle.
Perceived and actual arm performance in multiple sclerosis: relationship with clinical tests according to hand dominance
Authors: Lamers Ilse , Kerkhofs Lore , Raats Joke , Kos Daphne , Van Wijmeersch Bart , Feys Peter 
Published: February 2013

Background: The real-life relevance of frequently applied clinical arm tests is not well known in multiple sclerosis (MS). Objective: This study aimed to determine the relation between real-life arm performance and clinical tests in MS. Methods: Thirty wheelchair-bound MS patients and 30 healthy controls were included. Actual and perceived real-life arm performance was measured by using accelerometry and a self-reported measure (Motor Activity Log). Clinical tests on ‘body functions & structures’ (JAMAR handgrip strength, Motricity Index (MI), Fugl Meyer (FM)) and ‘activity’ level (Nine Hole Peg Test (NHPT), Action Research Arm test) of the International Classification of Functioning were conducted. Statistical analyses were performed separately for current dominant and non-dominant arm. Results: For all outcome measures, MS patients scored with both arms significantly lower than the control group. Higher correlations between actual arm performance and clinical tests were found for the non-dominant arm (0.63–0.80). The FM (55%) was a good predictor of actual arm performance, while the MI (46%) and NHPT (55%) were good predictors of perceived arm performance. Conclusions: Real-life arm performance is decreased in wheelchair-bound MS patients and can be best predicted by measures on ‘body functions & structures’ level and fine motor control. Hand dominance influenced the magnitude of relationships.
CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype
Authors: Masetti Riccardo , Pigazzi Martina , Togni Marco , Astolfi Annalisa , Indio Valentina , Manara Elena , Casadio Rita , Pession Andrea , Basso Giuseppe , Locatelli Franco 
Published: February 2013

Key Points
The CBFA2T3-GLIS2 fusion transcript is common in pediatric cytogenetically normal AML and not restricted to FAB M7 subtype. The CBFA2T3-GLIS2 fusion transcript is associated with poor prognosis in pediatric patients with AML.
RETRACTED ARTICLE: Fuzzy fractional Ostrowski inequality with Caputo differentiability
Authors: Allahviranloo Tofigh , Avazpour Lutfi , Ebadi Mohammad J , Baleanu Dumitru , Salahshour Soheil 
Published: February 2013

Abstract

Abstract
The use of fractional inequalities in mathematical models is increasingly widespread in recent years. In this manuscript, we firstly propose the right Caputo derivative of fuzzy-valued functions about fractional order ν (

0
<
ν
<
1

). To this end, we consider two types of differentiability (similar to the non-fractional case). Then we derive the equivalent integral forms of original fuzzy fractional differential equations. Finally, we prove the fuzzy Ostrowski inequality involving three functions under Caputo’s differentiability. In this regard, we state some new results.
Learning contextual gene set interaction networks of cancer with condition specificity
Authors: Jung Sungwon , Verdicchio Michael , Kiefer Jeff , Hoff Daniel Von , Berens Michael , Bittner Michael , Kim Seungchan 
Published: February 2013

Abstract

Background
Identifying similarities and differences in the molecular constitutions of various types of cancer is one of the key challenges in cancer research. The appearances of a cancer depend on complex molecular interactions, including gene regulatory networks and gene-environment interactions. This complexity makes it challenging to decipher the molecular origin of the cancer. In recent years, many studies reported methods to uncover heterogeneous depictions of complex cancers, which are often categorized into different subtypes. The challenge is to identify diverse molecular contexts within a cancer, to relate them to different subtypes, and to learn underlying molecular interactions specific to molecular contexts so that we can recommend context-specific treatment to patients.

Results
In this study, we describe a novel method to discern molecular interactions specific to certain molecular contexts. Unlike conventional approaches to build modular networks of individual genes, our focus is to identify cancer-generic and subtype-specific interactions between contextual gene sets, of which each gene set share coherent transcriptional patterns across a subset of samples, termed contextual gene set. We then apply a novel formulation for quantitating the effect of the samples from each subtype on the calculated strength of interactions observed. Two cancer data sets were analyzed to support the validity of condition-specificity of identified interactions. When compared to an existing approach, the proposed method was much more sensitive in identifying condition-specific interactions even in heterogeneous data set. The results also revealed that network components specific to different types of cancer are related to different biological functions than cancer-generic network components. We found not only the results that are consistent with previous studies, but also new hypotheses on the biological mechanisms specific to certain cancer types that warrant further investigations.

Conclusions
The analysis on the contextual gene sets and characterization of networks of interaction composed of these sets discovered distinct functional differences underlying various types of cancer. The results show that our method successfully reveals many subtype-specific regions in the identified maps of biological contexts, which well represent biological functions that can be connected to specific subtypes.
Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer
Authors: Hudson Robert S , Yi Ming , Volfovsky Natalia , Prueitt Robyn L , Esposito Dominic , Volinia Stefano , Liu Chang-Gong , Schetter Aaron J , Van Roosbroeck Katrien , Stephens Robert M , Calin George A , Croce Carlo M , Ambs Stefan 
Published: February 2013

Abstract

Background
Ultraconserved regions (UCR) are genomic segments of more than 200 base pairs that are evolutionarily conserved among mammalian species. They are thought to have functions as transcriptional enhancers and regulators of alternative splicing. Recently, it was shown that numerous RNAs are transcribed from these regions. These UCR-encoded transcripts (ucRNAs) were found to be expressed in a tissue- and disease-specific manner and may interfere with the function of other RNAs through RNA: RNA interactions. We hypothesized that ucRNAs have unidentified roles in the pathogenesis of human prostate cancer. In a pilot study, we examined ucRNA expression profiles in human prostate tumors.

Methods
Using a custom microarray with 962 probesets representing sense and antisense sequences for the 481 human UCRs, we examined ucRNA expression in resected, fresh-frozen human prostate tissues (57 tumors, 7 non-cancerous prostate tissues) and in cultured prostate cancer cells treated with either epigenetic drugs (the hypomethylating agent, 5-Aza 2′deoxycytidine, and the histone deacetylase inhibitor, trichostatin A) or a synthetic androgen, R1881. Expression of selected ucRNAs was also assessed by qRT-PCR and NanoString®-based assays. Because ucRNAs may function as RNAs that target protein-coding genes through direct and inhibitory RNA: RNA interactions, computational analyses were applied to identify candidate ucRNA:mRNA binding pairs.

Results
We observed altered ucRNA expression in prostate cancer (e.g., uc.106+, uc.477+, uc.363 + A, uc.454 + A) and found that these ucRNAs were associated with cancer development, Gleason score, and extraprostatic extension after controlling for false discovery (false discovery rate < 5% for many of the transcripts). We also identified several ucRNAs that were responsive to treatment with either epigenetic drugs or androgen (R1881). For example, experiments with LNCaP human prostate cancer cells showed that uc.287+ is induced by R1881 (P < 0.05) whereas uc.283 + A was up-regulated following treatment with combined 5-Aza 2′deoxycytidine and trichostatin A (P < 0.05). Additional computational analyses predicted RNA loop-loop interactions of 302 different sense and antisense ucRNAs with 1058 different mRNAs, inferring possible functions of ucRNAs via direct interactions with mRNAs.

Conclusions
This first study of ucRNA expression in human prostate cancer indicates an altered transcript expression in the disease.
Silver nanoparticles of Albizia adianthifolia: the induction of apoptosis in human lung carcinoma cell line
Authors: Govender Rishalan , Phulukdaree Alisa , Gengan Robert M , Anand Krishnan , Chuturgoon Anil A 
Published: February 2013

AbstractBackgroundSilver nanoparticles (AgNP), the most popular nano-compounds, possess unique properties.Albizia adianthifolia(AA) is a plant of the Fabaceae family that is rich in saponins. The biological properties of a novel AgNP, synthesized from an aqueous leaf extract of AA (AAAgNP), were investigated on A549 lung cells. Cell viability was determined by the MTT assay. Cellular oxidative status (lipid peroxidation and glutathione (GSH) levels), ATP concentration, caspase-3/-7, -8 and −9 activities were determined. Apoptosis, mitochondrial (mt) membrane depolarization (flow cytometry) and DNA fragmentation (comet assay) were assessed. The expression of CD95 receptors, p53, bax, PARP-1 and smac/DIABLO was evaluated by flow cytometry and/or western blotting.ResultsSilver nanoparticles of AA caused a dose-dependent decrease in cell viability with a significant increase in lipid peroxidation (5-fold vs. control;p = 0.0098) and decreased intracellular GSH (p = 0.1184). A significant 2.5-fold decrease in cellular ATP was observed upon AAAgNPexposure (p = 0.0040) with a highly significant elevation in mt depolarization (3.3-fold vs. control;p < 0.0001). Apoptosis was also significantly higher (1.5-fold) in AAAgNPtreated cells (p < 0.0001) with a significant decline in expression of CD95 receptors (p = 0.0416). Silver nanoparticles of AA caused a significant 2.5-fold reduction in caspase-8 activity (p = 0.0024) with contrasting increases in caspase-3/-7 (1.7-fold vs. control;p = 0.0180) and −9 activity (1.4-fold vs. control;p = 0.0117). Western blots showed increased expression of smac/DIABLO (4.1-fold) in treated cells (p = 0.0033). Furthermore, AAAgNPsignificantly increased the expression of p53, bax and PARP-1 (1.2-fold;p = 0.0498, 1.6-fold;p = 0.0083 and 1.1-fold;p = 0.0359 respectively).ConclusionData suggests that AAAgNPinduces cell death in the A549 lung cells via the mt mediated intrinsic apoptotic program. Further investigation is required to potentiate the use of this novel compound in cancer therapy trials.
BOOK REVIEWS
Authors: Marrone Daniel , Shamsavari Sina , Oksman Tahneer 
Published: February 2013

Lynda Barry: Girlhood through the Looking Glass, Susan E. Kirtley (2012) University Press of Mississippi, 217 pp., 9781617032356, Paperback, £25.99
No Straight Lines: Four Decades of Queer Comics, Justin Hall (ed.), Fantagraphics Books, 328 pp., 9781606995068, Hardback, $35
Projections:
Comics and the History of Twenty-First Century Storytelling, Jared Garner (2012) Palo Alto: Stanford University Press, 240 pp., ISBN: 978-08-04771474, Paperback, $24.95
Zwischen Innovation, User Involvement und digitaler Ausrichtung
Authors: Seitenbecher Manuel 
Published: February 2013

Zusammenfassung:
Am Jahresende 2014 bezieht die Hauptbibliothek Aarhus ihr neues Domizil im Urban Mediaspace. Der Weg dorthin ist geprägt von innovativen Projekten und dem Ausbau der Öffentlichen Bibliothek zur interaktiven Erlebnisstätte, von User Involvement und der verstärkten Fokussierung auf digitale Angebote. Manuel Seitenbecher konnte diesen Prozess vier Wochen lang begleiten. Der Bericht gibt einen Überblick über die vorbildliche Arbeit des Teams der Hauptbibliothek Aarhus sowie über aktuelle Entwicklungen im dänischen Bibliothekswesen.
Quantitative structure-activity relationship analysis of thiazolidineones: potent antidiabetic compounds
Authors: Vishvakarma Vijay Kumar , Singh Prashant , Dubey Monica , Kumari Kamlesh , Chandra Ramesh , Pandey Narender D. 
Published: February 2013

Abstract

Background: Type 2 diabetes is the most common form of diabetes, accounting for over 90% of cases. Current treatment approaches for type 2 diabetes include diet, exercise, and a variety of pharmacologic agents, including insulin, biguanides, sulfonylureas, and thiazolidinediones.

Methods: In the present scenario, researchers focused themselves on thiazolidine ring-based compounds to cure type 2 diabetes mellitus. Among the peroxisome proliferator activated receptor (PPAR) family, PPAR-γ is the most effective in curing glucose homeostasis.

Results and conclusions: Thiazolidine ring-based compounds act as PPAR-γ agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.
Electrical application of polystyrene (PS) reinforced with old tire rubber (GTR): dielectric, thermal, and mechanical properties
Authors: Mujal-Rosas Ramon , Ramis-Juan Xavier 
Published: February 2013

AbstractMass production of tires and their subsequent storage after use are serious environmental problems that are being tried to be solved in various ways. One of these is the mixture of these old used tires [ground rubber tire (GTR)] with various thermoplastic and thermostable polymers. The present work aimed to obtain materials suitable for the electric industry from the mixture of polystyrene (PS) with old used tires (GTR), starting from the requirement of minimum recycling costs, i.e., by using vulcanized GTR without any prior treatment but acting on the particle sizes with a simple and inexpensive screening. In order to do so, dielectric, mechanical, thermal, and microstructure analyses were performed for a large number of compounds, which were obtained using three GTR particle sizes (p<200 μm, 200 μm<p<500 μm, and p>500 μm) and seven concentrations of GTR in the compound (0%, 5%, 10%, 20%, 40%, 50%, and 70%). All these data have allowed an accurate characterization of the properties of the new compounds, and according to these results, possible electrical applications have been explored.
Isothermal Stress Relaxation in Passivated Alsicu- and Al- Lines with Different Aspect Ratios
Authors: Roths Ch. , Hönings J. , Eppler I. , Schroeder H. 
Published: February 2013

ABSTRACTMechanical stress relaxation in passivateci metal lines generally has two components, shear relaxation at constant volume, changing the stress distribution, and volumetric relaxation changing the hydrostatic stress. In order to contribute to the understanding of the underlying mechanisms we have collected detailed data on relaxation of passivated Al- and AlSiCu-lines with different aspect ratios a (0.2 ≤ a ≤ 1) and different thicknesses. A bending beam technique was used to measure the stress of these lines during thermal cycling from RT to 450°C and isothermal relaxation at different temperatures between RT and 350°C. Main results are: i) During thermal cycling the stress at RT and the total stress amplitude increase with increasing aspect ratio a, while stress hysteresis formation increases with decreasing a. ii) During isothermal relaxation the relaxed stress is strongly dependent on temperature with maxima between 150 and 250°C. The maximum shifts to lower temperatures with decreasing aspect ratio. From the temperature dependence the effective activation energy of 0.6±0.3eV for AlSiCu can be determined, iii) Finite element calculation and the method of “eigenstrains” are used to estimate seperately volumetric (voiding) and shear plasticity in these lines. Clearly voiding dominates the isothermal stress relaxation in all measured samples.
Residual Ion Implantation Damage at Source/Drain Junctions of Excimer Laser Annealed Polycrystalline Silicon Thin Film Transistor
Authors: Park Kee-Chan , Kim Jae-Shin , Nam Woo-Jin , Han Min-Koo 
Published: February 2013

AbstractResidual ion implantation damage at source/drain junctions of excimer laser annealed polycrystalline silicon (poly-Si) thin film transistor (TFT) was investigated by high-resolution transmission electron microscopy (HR-TEM). Cross-sectional TEM observation showed that XeCl excimer laser (λ=308 nm) energy decreased considerably at the source/drain junctions of top-gated poly-Si TFT due to laser beam diffraction at the gate electrode edges and that the silicon layer amorphized by ion implantation, was not completely annealed at the juncions. The HR-TEM observation showed severe lattice disorder at the junctions of poly-Si TFT.
The Influence of Socioeconomic Markers on the Association Between Fine Particulate Matter and Hospital Admissions for Respiratory Conditions Among Children
Authors: Yap Poh-Sin , Gilbreath Susan , Garcia Cynthia , Jareen Nargis , Goodrich Bryan 
Published: February 2013

Objectives. We evaluated the influence of socioeconomic status (SES) on hospital admissions for respiratory conditions associated with ambient particulate matter that is 2.5 micrometers or less in aerodynamic diameter (PM2.5) in children aged 1 to 9 years in 12 California counties, from 2000 to 2005. Methods. We linked daily hospital admissions for respiratory conditions (acute respiratory infections, pneumonia, and asthma) to meteorological, air pollution, and census data. Results. In San Diego, San Bernardino, Riverside, and Los Angeles counties, the admission rates for children associated with PM2.5 ranged from 1.03 to 1.07 for combined respiratory conditions and 1.03 to 1.08 for asthma in regions with lower SES. We observed 2 distinct patterns of the influence of the composite SES Townsend index. In lower-SES South Coast areas, PM2.5-associated hospital admission rates for all respiratory outcomes were predominantly positive whereas results in the Central Valley were variable, often tending toward the null. Conclusions. These distinct patterns could be attributed to the heterogeneity of regional confounders as well as the seasonal variation of emission sources of PM2.5. Composite SES is one potential factor for increasing susceptibility to air pollution.
Military Exceptionalism or Tobacco Exceptionalism: How Civilian Health Leaders' Beliefs May Impede Military Tobacco Control Efforts
Authors: Smith Elizabeth A. , Malone Ruth E. 
Published: February 2013

Smoking impairs the readiness and performance of military personnel, yet congressional opposition has thwarted military tobacco control initiatives. Involvement of civilian organizations might alter this political dynamic. We interviewed 13 leaders of national civilian public health and tobacco control organizations to explore their perspectives on military tobacco control, inductively analyzing data for themes. Leaders believed that military tobacco use was problematic but lacked specific knowledge. Most supported smoke-free policies and prohibiting smoking in uniform; however, they opposed banning tobacco use, arguing that it would violate smokers’ rights. Most leaders inappropriately applied civilian models of policy development to the military context. A tobacco-free military is unlikely to be achieved without military–civilian partnerships that include educating civilian health leaders about military policy development and implementation.
Abortion Law Around the World: Progress and Pushback
Authors: Finer Louise , Fine Johanna B. 
Published: February 2013

There is a global trend toward the liberalization of abortion laws driven by women’s rights, public health, and human rights advocates. This trend reflects the recognition of women’s access to legal abortion services as a matter of women’s rights and self-determination and an understanding of the dire public health implications of criminalizing abortion. Nonetheless, legal strategies to introduce barriers that impede access to legal abortion services, such as mandatory waiting periods, biased counseling requirements, and the unregulated practice of conscientious objection, are emerging in response to this trend. These barriers stigmatize and demean women and compromise their health. Public health evidence and human rights guarantees provide a compelling rationale for challenging abortion bans and these restrictions.