bluuebunny/crossref_metadata_2025_split huggingface dataset:
The incremental and cumulative effects of dynamic capability building on service innovation in collaborative service organizations
Authors: Agarwal Renu , Selen Willem 
Published: May 2014

AbstractIncreasingly, innovation in services is brought to market by a network of firms, or alliance networks, asset orchestration, knowledge sharing capabilities, resources and competencies, and operated in a coordinated manner. Recent literature has recognized the evolutionary nature of dynamic capabilities in that managers may adapt their alliance networks dynamically to sustain competitive advantage, as well as identified a continuing gap in the lack of empirical studies on feedbacks between network environments, dynamic capabilities, and innovation performance. In addition, other literature calls for more quantitative research on examining dynamic capabilities in a network environment to provide a better understanding of how firms should direct their resources and capabilities to successfully respond to competition. This study contributes towards closing both gaps by empirically examining thecumulative and incrementaleffects of fostering and deploying different dynamic capabilities on services innovation, and by quantifying their impact, thus providing managers with a better account of how services innovation comes about in a service value network. It does so using empirical data from 449 respondents from a telecommunications service provider in Australia and its partnering organizations, using structural equation modelling.
Inward−outward guanxi contagion and employees’ responses to managerial guanxi practices
Authors: Jiang Han , Cannella Albert , Gao Lifang , Jiao Jie 
Published: May 2014

AbstractOur study develops a new conceptual framework in which guanxi practices (managerial use of interpersonal ties to benefit their organizations) are analyzed by their focus (resources flowing inward or resources flowing outward) and their base (familiar – based on friendship ties; or family – based on kinship ties). Using this framework, we highlight the linkage between costs and benefits from using guanxi in Chinese business organizations, and show how the linkage depends on the guanxi base. Finally, we show how guanxi focus and guanxi base importantly affect employee responses to the use of guanxi practices in their organizations.
Postglacial Fringing-Reef to Barrier-Reef conversion on Tahiti links Darwin's reef types
Authors: Blanchon Paul , Granados-Corea Marian , Abbey Elizabeth , Braga Juan C. , Braithwaite Colin , Kennedy David M. , Spencer Tom , Webster Jody M. , Woodroffe Colin D. 
Published: May 2014

AbstractIn 1842 Charles Darwin claimed that vertical growth on a subsiding foundation caused fringing reefs to transform into barrier reefs then atolls. Yet historically no transition between reef types has been discovered and they are widely considered to develop independently from antecedent foundations during glacio-eustatic sea-level rise. Here we reconstruct reef development from cores recovered by IODP Expedition 310 to Tahiti and show that a fringing reef retreated upslope during postglacial sea-level rise and transformed into a barrier reef when it encountered a Pleistocene reef-flat platform. The reef became stranded on the platform edge, creating a lagoon that isolated it from coastal sediment and facilitated a switch to a faster-growing coral assemblage dominated by acroporids. The switch increased the reef's accretion rate, allowing it to keep pace with rising sea level and transform into a barrier reef. This retreat mechanism not only links Darwin's reef types, but explains the re-occupation of reefs during Pleistocene glacio-eustacy.
Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X3 inhibits the release of a pain mediator
Authors: Ma Hui , Meng Jianghui , Wang Jiafu , Hearty Stephen , Dolly J. Oliver , O’Kennedy Richard 
Published: May 2014

P2X3 (P2X purinoceptor 3) is predominantly expressed on nociceptive sensory neurons and plays a crucial role in signalling leading to chronic inflammatory pain and some features of neuropathic pain. Thus it represents a potential target for pain therapeutics. BoNT/A (botulinum neurooxin type A) effectively relieves certain types of pain through inhibiting the neuronal release of pain peptides. A recombinant single-chain variable fragment (scFv) antibody designated MH7C was generated against the extracellular domain of P2X3 using phage display. The genes encoding the scFv and activated di-chain form of BoNT/A without the C-terminal-binding subdomain (LC–HN–HCN/A) were ligated and expressed in Escherichia coli cells as a composite fusion protein. The purified protein bound and entered P2X3-containing sensory neurons, cleaved synaptosomal-associated protein of 25 kDa and inhibited the release of a pain peptide. This novel fusion protein designated ‘LC–HN–HCN/A–MH7C’ has potential clinical applications in the treatment of chronic inflammatory and sympathetically maintained neuropathic pain.
HEXIM1 plays a critical role in the inhibition of the androgen receptor by anti-androgens
Authors: Yeh I-Ju , Song Kyung , Wittmann Bryan M. , Bai Xiaodong , Danielpour David , Montano Monica M. 
Published: May 2014

We show that HEXIM1 (hexamethylene bis-acetamide inducible 1) functions as an AR (androgen receptor) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation. Oncomine™ database and IHC (immunohistochemistry) analyses of human prostate tissues revealed that expression of HEXIM1 mRNA and protein are down-regulated during the development and progression of prostate cancer. Enforced down-regulation of HEXIM1 in parental hormone-dependent LNCaP cells results in resistance to the inhibitory action of anti-androgens. Conversely, ectopic expression of HEXIM1 in the CRPC (castration-resistant prostate cancer) cell line, C4-2, enhances their sensitivity to the repressive effects of the anti-androgen bicalutamide. Novel insight into the mechanistic basis for HEXIM1 inhibition of AR activity is provided by the present studies showing that HEXIM1 induces expression of the histone demethylase KDM5B (lysine-specific demethylase 5B) and inhibits histone methylation, resulting in the inhibition of FOXA1 (forkhead box A1) licensing activity. This is a new mechanism of action attributed to HEXIM1, and distinct from what has been reported so far to be involved in HEXIM1 regulation of other nuclear hormone receptors, including the oestrogen receptor.
Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels
Authors: Reyhani Vahid , Seddigh Pegah , Guss Bengt , Gustafsson Renata , Rask Lars , Rubin Kristofer 
Published: May 2014

The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen type I) and used the Col I fibre network as a base to provide a functional interface matrix that connects cells to the Col I fibres through αVβ3 integrins. This allowed murine myoblast C2C12 cells to contract the collagenous composite gel via αVβ3 integrin. We show that fibrinogen specifically bound to immobilized native Col I at the site known to bind matrix metalloproteinase-1, discoidin domain receptor-2 and fibronectin, and that binding had no effect on Col I fibrillation. A specific competitive inhibitor blocking the Col-I-binding site for fibrinogen abolished the organization of fibrin into discernable fibrils, as well as the C2C12-mediated contraction of Col I gels. Our data show that fibrin can function as a linkage protein between Col I fibres and cells, and suggest that fibrin at inflammatory sites indirectly connects αVβ3 integrins to Col I fibres and thereby promotes cell-mediated contraction of collagenous tissue structures.
A conformational change of C-reactive protein in burn wounds unmasks its proinflammatory properties
Authors: Braig David , Kaiser Benedict , Thiele Jan R. , Bannasch Holger , Peter Karlheinz , Stark G. Björn , Koch Hans-Georg , Eisenhardt Steffen U. 
Published: May 2014

AbstractTissue damage in burn injury leads to a rapid increase of leukocytes and acute phase reactants. Plasma levels of C-reactive protein (CRP) rise within hours after the insult. No deficiency of this protein has been reported in humans, suggesting it plays a pivotal role in innate immunity. CRP in circulation is composed of five identical subunits [pentameric CRP (pCRP)]. Recently, deposits of structurally modified CRP (mCRP) have been found in inflammatory diseases. Little is known about this structural change and how it affects CRP functions. We analyzed CRP deposits in burn wounds and serum by immunohistochemistry, western blot and dot blot analysis. CRP was deposited in necrotic and inflamed tissue, but not in adjacent healthy tissue. Tissue deposited CRP was detected by mCRP-specific antibodies and structurally different from serum pCRP. mCRP but not pCRP induced reactive oxygen species production by monocytes and facilitated uptake of necrotic Jurkat cells by macrophages. In addition, it accelerated migration of keratinocytes in a scratch wound assay. The structural changes that occur in pCRP upon localization to damaged and inflamed tissue in burn wounds result in a functionally altered protein with distinct functions. mCRP exhibits opsonic, proinflammatory and promigratory properties which modulate wound healing.
Fusarium Wilt of Lettuce Caused by Fusarium oxysporum f. sp. lactucae in Argentina
Authors: Malbrán I. , Mourelos C. A. , Mitidieri M. S. , Ronco B. L. , Lori G. A. 
Published: May 2014

The green belt area surrounding the city of La Plata, Argentina, produces more than 70% (around 280 ha) of the lettuce (Lactuca sativa L.) cultivated under greenhouse for fresh consumption in the country. In February 2011, April 2012, and December 2013, butterhead lettuce plants from cv. Lores showing wilt and stunted growth symptoms, red-to-brown discoloration of vascular tissues, and yellow leaves were found in greenhouses in La Plata. Sections of tap root, crown and stem from symptomatic plants showing dark-brown streaking of the vascular tissue were surface sterilized and isolations were made. A total of 21 monosporic isolates obtained from different lettuce production fields were identified as Fusarium oxysporum Schltdl. based on morphological characteristics (2). Vegetative compatibility group (VCG) analysis (1) was conducted on 11 of these isolates and all isolates belonged to the same VCG. To fulfil Koch's postulates, two pathogenicity tests were conducted with these 11 isolates in winter (July 2012) and summer (December 2013). Healthy 20-day-old butterhead lettuce seedlings of two cultivars (Reina de Mayo and Lores in the winter and summer tests, respectively) were inoculated by dipping the roots of each plant in a spore suspension (~3 × 105 CFU ml−1), planted in 1-liter pots containing autoclaved soil and grown in a greenhouse with only natural daylight. Control treatments were prepared by dipping the seedling roots in sterilized distilled water. All inoculated plants showed wilt symptoms 15 to 20 days after inoculation (dai) and 45 to 50 dai in the summer and winter pathogenicity tests, respectively. The delay in the appearance of symptoms observed during the winter test is consistent with the effect of planting date on the development and final incidence of Fusarium wilt of lettuce reported by Matheron et al. (3). No symptoms were observed in control treatments. F. oxysporum was re-isolated from vascular tissues of the stems of symptomatic plants and the formae speciales lactucae J.C. Hubb. & Gerik was confirmed by PCR using the specific primer pair GYCF1 and R943 (4). The identification of only one VCG for the tested isolates agrees with the hypothesis of seed transmission of the pathogen, which might explain the dissemination of Fusarium wilt of lettuce in geographically distant areas (2). Studies are being carried out to determine the race of these Argentinian isolates of F. oxysporum f. sp. lactucae. To our knowledge, this is the first report of F. oxysporum f. sp. lactucae infecting lettuce in Argentina. References: (1) J. C. Correll et al. Phytopathology 77:1640, 1987. (2) J. F. Leslie and B. A. Summerell. The Fusarium Laboratory Manual. Blackwell Publishing, Ames, IA, 2006. (3) M. E. Matheron et al. Plant Dis. 89:565, 2005. (4) G. C. Y. Mbofung and B. M. Pryor. Plant Dis. 94:860, 2010.
Identifying risks inherent in farmer cooperatives in China
Authors: Zhang Ying , Hui Huang Zu 
Published: May 2014

Purpose
– The purpose of this paper is to investigate risks faced by farmer cooperatives in China, using farmer cooperatives in Zhejiang province as a case. Specifically, the authors identify risks inherent in two primary types of farmer cooperatives in China (traditional and modern ones) when the external environment changes, the cooperative size expands and heterogeneity in membership widens.

Design/methodology/approach
– The authors assume that the “uncertainty of the external environment” and the “deviation of organisational adaptation” constitute the two dynamic factors that generated risks for farmer cooperatives. A survey of 158 farmer cooperatives is obtained in Zhejiang province in 2010, and factor analysis is employed to identify the risks and their critical degrees of traditional and modern cooperatives.

Findings
– The results indicate that two types of cooperatives in China face drastically different sets of risks. Traditional cooperatives face larger competitive and human resources risks, whereas modern cooperatives face larger decision-making and behavioural risks. Product market risk, macroeconomic policy risk and financial risk are common critical risks faced by both types of cooperatives.

Originality/value
– In this paper, risks in China's farmer cooperatives were empirically studied and systematically discussed. The paper offers a typology to identify risks inherent in two primary types of farmer cooperatives in China (traditional and modern ones) according to property rights arrangements and governance structure.
Minimum energy control of descriptor positive discrete-time linear systems
Authors: Kaczorek Tadeusz 
Published: May 2014

Purpose– The purpose of this paper is to formulate and solve the minimum energy control problem of descriptor positive discrete-time linear systems.Design/methodology/approach– A procedure for computation of the optimal input sequences and the minimal value of the performance index is proposed.Findings– Necessary and sufficient conditions for the positivity and reachability of descriptor positive discrete-time linear systems and sufficient conditions for the existence of solution to the minimum energy control problem are given.Originality/value– A method for solving of the minimum energy control problem of descriptor positive discrete-time linear systems is proposed.
Topology optimization of magnetostatic shielding using multistep evolutionary algorithms with additional searches in a restricted design space
Authors: Okamoto Yoshifumi , Tominaga Yusuke , Wakao Shinji , Sato Shuji 
Published: May 2014

Purpose
– The purpose of this paper is to improve the multistep algorithm using evolutionary algorithm (EA) for the topology optimization of magnetostatic shielding, and the paper reveals the effectiveness of methodology by comparison with conventional optimization method. Furthermore, the design target is to obtain the novel shape of magnetostatic shielding.

Design/methodology/approach
– The EAs based on random search allow engineers to define general-purpose objects with various constraint conditions; however, many iterations are required in the FEA for the evaluation of the objective function, and it is difficult to realize a practical solution without island and void distribution. Then, the authors proposed the multistep algorithm with design space restriction, and improved the multistep algorithm in order to get better solution than the previous one.

Findings
– The variant model of optimized topology derived from improved multistep algorithm is defined to clarify the effectiveness of the optimized topology. The upper curvature of the inner shielding contributed to the reduction of magnetic flux density in the target domain.

Research limitations/implications
– Because the converged topology has many pixel element unevenness, the special smoother to remove the unevenness will play an important role for the realization of practical magnetostatic shielding.

Practical implications
– The optimized topology will give us useful detailed structure of magnetostatic shielding.

Originality/value
– First, while the conventional algorithm could not find the reasonable shape, the improved multistep optimization can capture the reasonable shape. Second, An additional search is attached to the multistep optimization procedure. It is shown that the performance of improved multistep algorithm is better than that of conventional algorithm.
High-speed functionality optimization of five-phase PM machine using third harmonic current
Authors: Gong Jinlin , Aslan Bassel , Gillon Frédéric , Semail Eric 
Published: May 2014

Purpose– The purpose of this paper is to apply some surrogate-assisted optimization techniques in order to improve the performances of a five-phase permanent magnet machine in the context of a complex model requiring computation time.Design/methodology/approach– An optimal control of four independent currents is proposed in order to minimize the total losses with the respect of functioning constraints. Moreover, some geometrical parameters are added to the optimization process allowing a co-design between control and dimensioning.Findings– The optimization results prove the remarkable effect of using the freedom degree offered by a five-phase structure on iron and magnets losses. The performances of the five-phase machine with concentrated windings are notably improved at high speed (16,000 rpm).Originality/value– The effectiveness of the method allows solving the challenge which consists in taking into account inside the control strategy the eddy-current losses in magnets and iron. In fact, magnet losses are a critical point to protect the machine from demagnetization in flux-weakening region.
MHD nanofluid flow analysis in divergent and convergent channels using WRMs and numerical method
Authors: Hatami M. , Ganji D.D. 
Published: May 2014

Purpose
– The purpose of this paper is to demonstrate the eligibility of the Weighted Residual Methods (WRMs) applied to magneto hydro dynamic (MHD) nanofluid flow in divergent and convergent channels. Selecting the most appropriate method among the WRMs and discussing about Jeffery-Hamel flow's treatment in divergent and convergent channels are the other important purposes of the present research.

Design/methodology/approach
– Three analytical methods (Collocation, Galerkin and Least Square Method) and numerical method have been applied to solve the governing equations. The reliability of the methods is also approved by a comparison made between the fourth-order Runge-Kutta numerical method.

Findings
– The obtained solutions revealed that WRMs can be simple, powerful and efficient techniques for finding analytical solutions in science and engineering non-linear differential equations.

Originality/value
– It could be considered as a first endeavor to use the solution of the MHD nanofluid flow in divergent and convergent channels using these kinds of analytical methods along with the numerical approach.
A new algorithm for internal heat generation in nanofluid flow due to a stretching sheet in a porous medium
Authors: Kameswaran P.K. , Makukula Z.G. , Sibanda P. , Motsa S.S. , Murthy P.V.S.N. 
Published: May 2014

Purpose
– The purpose of this paper is to study heat and mass transfer in copper-water and silver-water nanofluid flow over stretching sheet placed in saturated porous medium with internal heat generation or absorption. The authors further introduce a new algorithm for solving heat transfer problems in fluid mechanics. The model used for the nanofluid incorporates the nanoparticle volume fraction parameter and a consideration of the chemical reaction effects among other features.

Design/methodology/approach
– The partial differential equations for heat and mass transfer in copper-water and silver-water nanofluid flow over stretching sheet were transformed into a system of nonlinear ordinary differential equations. Exact solutions for the boundary layer equations were obtained in terms of a confluent hypergeometric series. A novel spectral relaxation method (SRM) is used to obtain numerical approximations of the governing differential equations. The exact solutions are used to test the convergence and accuracy of the SRM.

Findings
– Results were obtained for the fluid properties as well as the skin friction, and the heat and mass transfer rates. The results are compared with limiting cases from previous studies and they show that the proposed technique is an efficient numerical algorithm with assured convergence that serves as an alternative to numerical methods for solving nonlinear boundary value problems.

Originality/value
– A new algorithm is used for the first time in this paper. In addition, new exact solutions for the energy and mass transport equations have been obtained in terms of a confluent hypergeometric series.
Education-based occupational segregation and the gender wage gap: evidence from France
Authors: Couppié Thomas , Dupray Arnaud , Moullet Stéphanie 
Published: May 2014

Purpose
– The purpose of this paper is to test whether the gender wage gap at the beginning of the working life in France varies with the gender composition of occupations (male-dominated, female-dominated or mixed) and its main determinant (educational pre-sorting or labour market sorting).

Design/methodology/approach
– The first stage of the methodology is to decompose segregation indexes at occupation level into the two components of determination noted above. The occupations are then divided into five groups on the basis of their gender composition and the weight of the educational segregation. Oaxaca-Blinder decompositions are then applied to each group.

Findings
– Among 54 strongly gendered occupations, the segregation in 26 stems mainly from educational pre-sorting. This context is favourable to reduction of the gender wage gap. However, a modest wage differential is not proof of convergence towards equity, as it may conceal the existence of a significant discrimination component, as in male occupations.

Research limitations/implications
– The results relate to a cohort of French youth. The earnings-equalizing impact of education-based occupational segregation should be tested in other national contexts.

Social implications
– Public authorities should put in place incentives to encourage women's participation in a greater range of education and training courses and to improve the matching between education and the skill content of jobs.

Originality/value
– The originality lies in the suggestion that a strong connection between education and skill requirements helps to narrow the occupational gender wage gap.