bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: On DABAL‐Me3 Promoted Formation of Amides.
Authors: Dubois Nathalie , Glynn Daniel , McInally Thomas , Rhodes Barrie , Woodward Simon , Irvine Derek J. , Dodds Chris 
Published: March 2014

AbstractRange and utility of couplings of methyl esters and free carboxylic acids with primary and secondary amines in the presence of DABAL‐Me3, an adduct of trimethylaluminum and DABCO, are studied.
ChemInform Abstract: Nanocrystalline Titania‐Based Sulfonic Acid (TiO2—Pr—SO3H) as a New, Highly Efficient and Recyclable Solid Acid Catalyst for the N‐Boc Protection of Amines at Room Temperature.
Authors: Atghia S. V. , Beigbaghlou S. Sarvi 
Published: March 2014

AbstractA simple protocol employing the title catalyst allows the N‐Boc protection of primary and secondary amines in short reaction times with excellent yields.
ChemInform Abstract: Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ent‐Sitagliptin.
Authors: Bao Hongli , Bayeh Liela , Tambar Uttam K. 
Published: March 2014

AbstractA two‐step ene‐reaction/[2,3]‐rearrangement for the enantioselective allylic amination of nonactivated olefins is developed.
ChemInform Abstract: A Novel p‐Terphenyl Derivative Inducing Cell‐Cycle Arrest and Apoptosis in MDA‐MB‐435 Cells Through Topoisomerase Inhibition.
Authors: Qiu Jin , Zhao Baobing , Shen Yan , Chen Wang , Ma Yudao , Shen Yuemao 
Published: March 2014

AbstractTerphenyl derivatives (III) and (IV) and 10 other OH‐ and OMe‐substituted derivatives are prepared, and their in vitro anticancer activities are evaluated.
ChemInform Abstract: Highly Enantioselective Iron(II)‐Catalyzed Opening Reaction of Aromatic meso‐Epoxides with Indoles.
Authors: Plancq Baptiste , Lafantaisie Mathieu , Companys Simon , Maroun Cendrella , Ollevier Thierry 
Published: March 2014

AbstractUnprecedented high enantioselectivities are obtained in the ring opening of cis‐stilbene oxide (II) with indoles (I) using iron perchlorate and a chiral bipyridine ligand as catalyst system.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Benzylation of Azlactones.
Authors: Trost Barry M. , Czabaniuk Lara C. 
Published: March 2014

AbstractThe asymmetric Pd‐catalyzed benzylation of prochiral azlactones with a variety of benzylic‐type compounds such as carbonates (I) and (IV) or phosphates such as (VI) and (VIII) by using enantiopure bis(diphenylphosphinobenzoyl)diamines as ligands is developed.
ChemInform Abstract: Recyclization of 4‐Alkyl(aryl)‐2,6‐diamino‐3,5‐dicyano‐4H‐thiopyrans with 2‐Aminoethanol and (2‐Furyl)methylamine.
Authors: Dyachenko V. D. , Rylskaya T. A. 
Published: March 2014

AbstractTitle reaction leading to pyridines (III) occurs through C—S cleavage, nucleophilic attack by amines (II), heterocyclization, and oxidative dehydrogenation.
ChemInform Abstract: Rh(III)‐Catalyzed C—H Activation and Double Directing Group Strategy for the Synthesis of Naphthyridinones.
Authors: Huckins John R. , Becot Eric A. , Thiel Oliver R. , Hwang Tsang‐Lin , Bio Matthew M. 
Published: March 2014

AbstractThe approach uses a double activation and directing properties of nicotinamide N‐oxides as substrates.
ChemInform Abstract: Tandem Grignard Addition/Aromatic Aza‐Cope Rearrangement Route to the Synthesis of 3,4‐Dihydropyrrolo[2,1‐a]isoquinoline Derivatives.
Authors: Huq C. A. M. A. , Raj A. R. Naresh 
Published: March 2014

AbstractThe first example for a one‐pot synthesis of functionalized dihydropyrroloisoquinoline derivatives (III) via a tandem Grignard addition/aromatic aza‐Cope rearrangement of arylmagnesium bromides and N‐vinyl‐2‐pyrrolidinone is described.
ChemInform Abstract: Design, Synthesis, Docking Study and Biological Evaluation of Some Novel Tetrahydrochromeno [3′,4′:5,6]Pyrano[2,3‐b]quinolin‐6(7H)‐one Derivatives Against Acetyl‐ and Butyrylcholinesterase.
Authors: Khoobi Mehdi , Alipour Masoumeh , Moradi Alireza , Sakhteman Amirhossein , Nadri Hamid , Razavi Seyyede Faeze , Ghandi Mehdi , Foroumadi Alireza , Shafiee Abbas 
Published: March 2014

Abstract18 Title compounds of type (III) are prepared and evaluated for their AChE and BuChE inhibitory activities.
ChemInform Abstract: Hydrazones Derived from Thiooxamohydrazides and 3‐Formyl‐4‐hydroxycoumarin: Synthesis, Structures, and Fragmentation.
Authors: Milevsky B. G. , Solov'eva N. P. , Chibisova T. A. , Yarovenko V. N. , Zayakin E. S. , Chernyshev V. V. , Krayushkin M. M. , Traven V. F. 
Published: March 2014

AbstractSeven hydrazones of type (III) are prepared.
ChemInform Abstract: 4,4‐Dimethyl‐3,4‐dihydro‐2H‐1,4‐thiasiline — The First Cyclic Organosilicon Vinyl Sulfide.
Authors: Suslova Elena N. , Shainyan Bagrat A. 
Published: March 2014

AbstractThe title compound (II) is obtained by Pummerer rearrangement of the corresponding sulfoxide (I) along with the hydrolysis by‐product (III).
ChemInform Abstract: Palladium‐Catalyzed Direct Synthesis of Phosphole Derivatives from Triarylphosphines Through Cleavage of Carbon—Hydrogen and Carbon—Phosphorus Bonds.
Authors: Baba Katsuaki , Tobisu Mamoru , Chatani Naoto 
Published: March 2014

AbstractA new palladium‐catalyzed method to prepare phosphole skeletons directly from triarylphosphines through C—H and C—P bond cleavage is developed.
ChemInform Abstract: Actinoranone, a Cytotoxic Meroterpenoid of Unprecedented Structure from a Marine Adapted Streptomyces sp.
Authors: Nam Sang‐Jip , Kauffman Christopher A. , Paul Lauren A. , Jensen Paul R. , Fenical William 
Published: March 2014

AbstractActinoranone (I) exhibits cytotoxicity against HCT‐116 human colon cancer cells.
Comprehensive, open‐source resource usage measurement and analysis for HPC systems
Authors: Browne James C. , DeLeon Robert L. , Patra Abani K. , Barth William L. , Hammond John , Jones Matthew D. , Furlani Thomas R. , Schneider Barry I. , Gallo Steven M. , Ghadersohi Amin , Gentner Ryan J. , Palmer Jeffrey T. , Simakov Nikolay , Innus Martins , Bruno Andrew E. , White Joseph P. , Cornelius Cynthia D. , Yearke Thomas , Marcus Kyle , von Laszewski Gregor , Wang Fugang 
Published: March 2014

SUMMARYThe important role high‐performance computing (HPC) resources play in science and engineering research, coupled with its high cost (capital, power and manpower), short life and oversubscription, requires us to optimize its usage – an outcome that is only possible if adequate analytical data are collected and used to drive systems management at different granularities – job, application, user and system. This paper presents a method for comprehensive job, application and system‐level resource use measurement, and analysis and its implementation. The steps in the method are system‐wide collection of comprehensive resource use and performance statistics at the job and node levels in a uniform format across all resources, mapping and storage of the resultant job‐wise data to a relational database, which enables further implementation and transformation of the data to the formats required by specific statistical and analytical algorithms. Analyses can be carried out at different levels of granularity: job, user, application or system‐wide. Measurements are based on a new lightweight job‐centric measurement tool ‘TACC_Stats’, which gathers a comprehensive set of resource use metrics on all compute nodes and data logged by the system scheduler. The data mapping and analysis tools are an extension of the XDMoD project. The method is illustrated with analyses of resource use for the Texas Advanced Computing Center's Lonestar4, Ranger and Stampede supercomputers and the HPC cluster at the Center for Computational Research. The illustrations are focused on resource use at the system, job and application levels and reveal many interesting insights into system usage patterns and also anomalous behavior due to failure/misuse. The method can be applied to any system that runs the TACC_Stats measurement tool and a tool to extract job execution environment data from the system scheduler. Copyright © 2014 John Wiley & Sons, Ltd.
Low‐dose γ‐radiation inhibits IL‐1β‐induced dedifferentiation and inflammation of articular chondrocytes via blockage of catenin signaling
Authors: Hong Eun‐Hee , Song Jie‐Young , Lee Su‐Jae , Park In‐Chul , Um Hong‐Duck , Park Jong Kuk , Lee Kee‐Ho , Nam Seon Young , Hwang Sang‐Gu 
Published: March 2014

AbstractAlthough low‐dose radiation (LDR) regulates a wide range of biological processes, limited information is available on the effects of LDR on the chondrocyte phenotype. Here, we found that LDR, at doses of 0.5–2 centiGray (cGy), inhibited interleukin (IL)‐1β‐induced chondrocyte destruction without causing side effects, such as cell death and senescence. IL‐1β treatment induced an increase in the expression of α‐, β‐, and γ‐catenin proteins in chondrocytes via Akt signaling, thereby promoting dedifferentiation through catenin‐dependent suppression of Sox‐9 transcription factor expression and induction of inflammation through activation of the NF‐κB pathway. Notably, LDR blocked cartilage disorders by inhibiting IL‐1β‐induced catenin signaling and subsequent catenin‐dependent suppression of the Sox‐9 pathway and activation of the NF‐κB pathway, without directly altering catenin expression. LDR also inhibited chondrocyte destruction through the catenin pathway induced by epidermal growth factor, phorbol 12‐myristate 13‐acetate, and retinoic acid. Collectively, these results identify the molecular mechanisms by which LDR suppresses pathophysiological processes and establish LDR as a potentially valuable therapeutic tool for patients with cytokine‐ or soluble factors‐mediated cartilage disorders. © 2014 The Authors IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 66(2):128–137, 2014
Optimization of the reference region method for dual pharmacokinetic modeling using Gd‐DTPA/MRI and 18F‐FDG/PET
Authors: Poulin Éric , Lebel Réjean , Croteau Étienne , Blanchette Marie , Tremblay Luc , Lecomte Roger , Bentourkia M'hamed , Lepage Martin 
Published: March 2014

PurposeThe combination of MRI and positron emission tomography (PET) offers new possibilities for the development of novel methodologies. In pharmacokinetic image analysis, the blood concentration of the imaging compound as a function of time, [i.e., the arterial input function (AIF)] is required for MRI and PET. In this study, we tested whether an AIF extracted from a reference region (RR) in MRI can be used as a surrogate for the manually sampled 18F‐FDG AIF for pharmacokinetic modeling.MethodsAn MRI contrast agent, gadolinium‐diethylenetriaminepentaacetic acid (Gd‐DTPA) and a radiotracer, 18F‐fluorodeoxyglucose (18F‐FDG), were simultaneously injected in a F98 glioblastoma rat model. A correction to the RR AIF for Gd‐DTPA is proposed to adequately represent the manually sampled AIF. A previously published conversion method was applied to convert this AIF into a 18F‐FDG AIF.ResultsThe tumor metabolic rate of glucose (TMRGlc) calculated with the manually sampled 18F‐FDG AIF, the 18F‐FDG AIF converted from the RR AIF and the 18F‐FDG AIF converted from the corrected RR AIF were found not statistically different (P > 0.05).ConclusionAn AIF derived from an RR in MRI can be accurately converted into a 18F‐FDG AIF and used in PET pharmacokinetic modeling. Magn Reson Med 73:740–748, 2015. © 2014 Wiley Periodicals, Inc.
Altered RIG‐I/DDX58‐mediated innate immunity in dermatomyositis
Authors: Suárez‐Calvet Xavier , Gallardo Eduard , Nogales‐Gadea Gisela , Querol Luis , Navas Miquel , Díaz‐Manera Jordi , Rojas‐Garcia Ricard , Illa Isabel 
Published: March 2014

AbstractWe investigated the molecular mechanisms involved in the pathogenesis of three inflammatory myopathies, dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). We performed microarray experiments† using microdissected pathological muscle fibres from 15 patients with these disorders and five controls. Differentially expressed candidate genes were validated by immunohistochemistry on muscle biopsies, and the altered pathways were analysed in human myotube cultures. Up‐regulation of genes involved in viral and nucleic acid recognition were found in the three myopathies but not in controls. In DM, retinoic acid‐inducible gene 1 (RIG‐I, DDX58) and the novel antiviral factor DDX60, which promotes RIG‐I‐mediated signalling, were significantly up‐regulated, followed by IFIH1 (MDA5) and TLR3. Immunohistochemistry confirmed over‐expression of RIG‐I in pathological muscle fibres in 5/5 DM, 0/5 PM and 0/5 IBM patients, and in 0/5 controls. Stimulation of human myotubes with a ligand of RIG‐I produced a significant secretion of interferon‐β (IFNβ; p < 0.05) and up‐regulation of class I MHC, RIG‐I and TLR3 (p < 0.05) by IFNβ‐dependent and TLR3‐independent mechanisms. RIG‐I‐mediated innate immunity, triggered by a viral or damage signal, plays a significant role in the pathogenesis of DM, but not in that of PM or IBM. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
MiR‐506 suppresses proliferation and induces senescence by directly targeting the CDK4/6–FOXM1 axis in ovarian cancer
Authors: Liu Guoyan , Sun Yan , Ji Ping , Li Xia , Cogdell David , Yang Da , Parker Kerrigan Brittany C , Shmulevich Ilya , Chen Kexin , Sood Anil K , Xue Fengxia , Zhang Wei 
Published: March 2014

AbstractOvarian carcinoma is the most lethal gynaecological malignancy. Better understanding of the molecular pathogenesis of this disease and effective targeted therapies are needed to improve patient outcomes. MicroRNAs play important roles in cancer progression and have the potential for use as either therapeutic agents or targets. Studies in other cancers have suggested that miR‐506 has anti‐tumour activity, but its function has yet to be elucidated. We found that deregulation of miR‐506 in ovarian carcinoma promotes an aggressive phenotype. Ectopic over‐expression of miR‐506 in ovarian cancer cells was sufficient to inhibit proliferation and to promote senescence. We also demonstrated that CDK4 and CDK6 are direct targets of miR‐506, and that miR‐506 can inhibit CDK4/6–FOXM1 signalling, which is activated in the majority of serous ovarian carcinomas. This newly recognized miR‐506–CDK4/6–FOXM1 axis provides further insight into the pathogenesis of ovarian carcinoma and identifies a potential novel therapeutic agent. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
Outpatient versus inpatient IV antibiotic management for pediatric oncology patients with low risk febrile neutropenia: A randomised trial
Authors: Orme Lisa M. , Babl Franz E. , Barnes Chris , Barnett Peter , Donath Susan , Ashley David M. 
Published: March 2014

BackgroundFebrile neutropenia (FN) is a frequent, serious complication of intensive pediatric chemotherapy regimens. The aim of this trial was to compare quality of life (QOL) between inpatient and outpatient intravenous antibiotic management of children and adolescents with low risk febrile neutropenia (LRFN).ProcedureIn this randomised non‐blinded trial, patients between 1 and 21 years old, receiving low/moderate intensity chemotherapy were pre‐consented and, on presentation to emergency (ED) with FN satisfying low risk criteria, randomised to either outpatient or inpatient care with intravenous cefepime 50 mg/kg (12 hourly). All patients continued antibiotics for at least 48 hours, until afebrile for 24 hours and demonstrating a rising absolute neutrophil count ≥200/mm3. Several domains of QOL were examined by daily questionnaire.ResultsEighty‐one patients presented to ED with 159 episodes of fever. Thirty‐seven FN presentations involving 27 patients were randomised to inpatient (18) and outpatient (19) management. Combined QOL mean scores for parents were higher for the outpatient group and scores for three specific parent variables (keeping up with household tasks/time spent with partner/time spent with other children) were higher among outpatients. There was no difference in parent confidence/satisfaction in care between groups. Patients scored better in the outpatient group overall and for sleep and appetite. The mean length of fever was equivalent between groups and there were no serious adverse events attributable to cefepime or outpatient care.ConclusionOutpatient cefepime management of LRFN provided significant benefit to parents and patients across several QOL domains and appeared both feasible and safe. Pediatr Blood Cancer 2014; 61:1427–1433. © 2014 Wiley Periodicals, Inc.
Changes in protein expression in rat bronchoalveolar lavage fluid after exposure to zinc oxide nanoparticles: an iTRAQ proteomic approach
Authors: Juang Yu‐Min , Lai Ben‐Heng , Chien Han‐Ju , Ho Meng , Cheng Tsun‐Jen , Lai Chien‐Chen 
Published: March 2014

RATIONALEZinc oxide nanoparticles (ZnO NPs) are widely used in consumer products and various biomedical fields. As a result, humans are frequently exposed to these NPs. However, there is a lack of information about the proteins that are expressed in the airway in response to exposure to ZnO NPs.METHODSBronchoalveolar lavage fluid (BALF) from Sprague‐Dawley (SD) rats that had been exposed to high‐dose 35 nm ZnO NPs (N = 6) and filtered air (N = 4) was collected and then labeled with isobaric tags for relative and absolute quantitation (iTRAQ). The differentially expressed proteins were identified by two‐dimensional liquid chromatography/tandem mass spectrometry (2D‐LC/MS/MS) and further classified by Gene Ontology (GO) annotation.RESULTSA total of 46 proteins displayed significant changes after exposure. GO annotation of these differentially expressed proteins indicated that exposure to ZnO NPs mainly affected immune and inflammatory processes. Furthermore, S100A8 and S100A9, candidate markers of idiopathic pulmonary fibrosis and lung cancer, were significantly up‐regulated (2.78‐ and 2.87‐fold, respectively) following exposure.CONCLUSIONSOur data are consistent with recent study results that exposure to ZnO NPs induces lung inflammation. These data contribute to a better understanding of how exposure to ZnO NPs leads to lung damage through the functional classification of these proteins. Copyright © 2014 John Wiley & Sons, Ltd.
Effects of Ownership on Hospital Efficiency in Germany
Authors: Tiemann Oliver , Schreyögg Jonas 
Published: March 2014

AbstractThe objective of our study was to evaluate the efficiency of public, private for-profit, and private non-profit hospitals in Germany. First, bootstrapped data envelopment analysis (DEA) was used to evaluate the efficiency of a panel (n = 1,046) of public, private for-profit, and private non-profit hospitals between 2002 and 2006. This was followed by a second-step truncated linear regression model with bootstrapped DEA efficiency scores as dependent variable. The results show that public hospitals performed significantly better than their private for-profit and non-profit counterparts. In addition, we found a significant positive association between hospital size and efficiency, and that competitive pressure had a significant negative impact on hospital efficiency.
VHB-JOURQUAL2: Method, Results, and Implications of the German Academic Association for Business Research’s Journal Ranking
Authors: Schrader Ulf , Hennig-Thurau Thorsten 
Published: March 2014

AbstractVHB-JOURQUAL represents the official journal ranking of the German Academic Association for Business Research. Since its introduction in 2003, the ranking has become the most influential journal evaluation approach in German-speaking countries, impacting several key managerial decisions of German, Austrian, and Swiss business schools. This article reports the methodological approach of the ranking’s second edition. It also presents the main results and additional analyses on the validity of the rating and the underlying decision processes of the respondents. Selected implications for researchers and higher-education institutions are discussed.
Path Constitution Analysis: A Methodology for Understanding Path Dependence and Path Creation
Authors: Sydow Jörg , Windeler Arnold , Müller-Seitz Gordon , Lange Knut 
Published: March 2014

AbstractAlthough an increasing number of studies of technological, institutional and organizational change refer to the concepts of path dependence and path creation, few attempts have been made to consider these concepts explicitly in their methodological accounts. This paper addresses this gap and contributes to the literature by developing a comprehensive methodology that originates from the concepts of path dependence and path creation — path constitution analysis (PCA) — and allows for the integration of multi-actor constellations on multiple levels of analysis within a process perspective. Based upon a longitudinal case study in the field of semiconductors, we illustrate PCA ‘in action’ as a template for other researchers and critically examine its adequacy. We conclude with implications for further path-oriented inquiries.
On Transport Service Selection in Intermodal Rail/Road Distribution Networks
Authors: Bierwirth Christian , Kirschstein Thomas , Meisel Frank 
Published: March 2014

AbstractIntermodal rail/road freight transport constitutes an alternative to long-haul road transport for the distribution of large volumes of goods. The paper introduces the intermodal transportation problem for the tactical planning of mode and service selection. In rail mode, shippers either book train capacity on a per-unit basis or charter block trains completely. Road mode is used for short-distance haulage to intermodal terminals and for direct shipments to customers. We analyze the competition of road and intermodal transportation with regard to freight consolidation and service cost on a model basis. The approach is applied to a distribution system of an industrial company serving customers in eastern Europe. The case study investigates the impact of transport cost and consolidation on the optimal modal split.
A Column-Generation Approach for a Short-Term Production Planning Problem in Closed-Loop Supply Chains
Authors: Sahling Florian 
Published: March 2014

AbstractWe present a new model formulation for a multi-product lot-sizing problem with product returns and remanufacturing subject to a capacity constraint. The given external demand of the products has to be satisfied by remanufactured or newly produced goods. The objective is to determine a feasible production plan, which minimizes production, holding, and setup costs. As the LP relaxation of a model formulation based on the well-known CLSP leads to very poor lower bounds, we propose a column-generation approach to determine tighter bounds. The lower bound obtained by column generation can be easily transferred into a feasible solution by a truncated branch-and-bound approach using CPLEX. The results of an extensive numerical study show the high solution quality of the proposed solution approach.