bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKTOR YANG MEMPENGARUHI PENURUNAN ANGKA PERNIKAHAN DI INDONESIA
Authors: Ningtias Indira Setia 
Published: August 2024

Pertumbuhan penduduk yang tidak terkendali akan menimbulkan berbagai masalah, baik dari aspek lingkungan, sosial, hingga budaya. Malthus dalam teorinya telah memprediksi kondisi pertumbuhan penduduk yang semakin tidak terkendali, pembatasan pertumbuhan penduduk yang mungkin dapat dilakukan adalah dengan pengekangan diri dengan menunda pernikahan. Pernikahan merupakan salah satu peristiwa kependudukan diakui legalitasnya apabila pasangan sudah terdaftar dan memperoleh dokumen kependudukan sebagai bukti keabsahan. Namun dalam sepuluh tahun terakhir terjadi penurunan angka pernikahan di Indonesia. Penelitian ini berfokus pada kondisi turunnya angka pernikahan didasari oleh dimensi Preventife Checks dalam teori yang dikemukakan Malthus, mengingat dimensi Positive Checks merupakan dimensi yang tidak diharapkan terjadi. Metode penulisan menggunakan library research dengan mengumpulkan berbagai sumber studi pustaka dan internet. Hasil penelitian menunjukan pertumbuhan penduduk di Indonesia khususnya yang terjadi pada 5 (lima) tahun terakhir mengalami penurunan seiring dengan turunnya angka pernikahan. Hal ini dipengaruhi berbagai fenomena yang berkembang di Indonesia diantaranya globalisasi yang berpengaruh pada pola pikir anak usia muda saat ini, masalah sosial yang menuntut standar kesuksesan, fenomena naiknya angka perceraian dalam masyarakat yang mempengaruhi mental calon pasangan muda, pandemi covid-19, lahirnya Undang-undang Nomor 16 Tahun 2019 serta fenomena nikah siri yang menjadikan pernikahan tersebut tidak tercatat dan tidak diakui secara hukum.

Kata kunci : dokumen kependudukan; globalisasi; pernikahan; pertumbuhan penduduk; undang-undang.
Efektivitas Pemberian Edukasi Dengan Metode Focus Group Discussion (FGD) Menggunakan Media Audio-Visual Terhadap Rasionalitas Penggunaan Antibiotik Di Desa Kresik Bura
Authors: Mursidah Diana Aulia , Saputri Rina , Aryzki Saftia , Syamsu Erlina 
Published: August 2024

Latar belakang: Penggunaan antibiotik yang tidak rasional dapat menyebabkan kegagalan terapi dan resiko resistensi. Salah satu faktor yang mempengaruhi penggunaan antibiotik yaitu pengetahuan yang dapat ditingkatkan dengan pemberian edukasi. Metode FGD bertujuan untuk mengeksplorasi masalah yang lebih spesifik berkaitan dengan topik yang dibahas. Edukasi dengan media audio-visual memudahkan dalam penyampaian informasi dan lebih mudah diterima oleh masyarakat.
Tujuan: Menganalisis efektivitas pemberian edukasi dengan metode Focus Group Discussion (FGD) menggunakan media audio-visual terhadap rasionalitas penggunaan antibiotik di masyarakat Desa Kresik Bura.
Metode: True eksperimental dengan desain pretest posttest control group. Teknik sampling yang digunakan adalah stratified random sampling dengan jumlah sampel sebanyak 100 responden. Penelitian ini dilakukan di Desa Kersik Bura pada Bulan Juni 2023-Juli 2023.
Hasil: Hasil rasionalitas penggunaan antibiotik sebelum edukasi dengan hasil rasional sebanyak 40%, setelah diberikan edukasi terjadi peningkatkan menjadi 72%. Hasil uji wilcoxon pada kelompok kontrol 0.180 dan pada kelompok eksperimen 0.000. Hasil uji mann-whitney diperoleh p-value 0.000.
Kesimpulan: Pemberian edukasi dengan metode FGD menggunakan media audio-visual efektif dalam meningkatkan rasionalitas penggunaan antibiotik.
Small pituitary volume and central nervous system anomalies in Fanconi Anemia
Authors: Corredor Beatriz , Solís Inés , Zubicaray Josune , Sevilla Julián , Argente Jesús 
Published: August 2024

IntroductionFanconi anemia (FA) is a genomic instability disorder associated with congenital abnormalities, including short stature and the presence of central nervous system anomalies, especially in the hypothalamic-pituitary area. Thus, differences in pituitary size could associate with the short stature observed in these patients. Our aim was to evaluate whether central nervous system abnormalities and pituitary gland volume correlate with height and hormone deficiencies in these patients.MethodsIn this cross-sectional exploratory study 21 patients diagnosed with FA between 2017 and 2022 in a Spanish Reference Center were investigated. Magnetic resonance imaging (MRI) was performed and pituitary volume calculated and corelated with height and other endocrine parameters.ResultsThe percentage of abnormalities in our series was 81%, with a small pituitary (pituitary volume less than 1 SD) being the most frequent, followed by Chiari malformation type 1. The median value of pituitary volume was -1.03 SD (IQR: -1.56, -0.36). Short stature was found in 66.7% [CI95% 43-85.4]. Total volume (mm3) increases significantly with age and in pubertal stages. There were no differences between volume SD and pubertal stage, or the presence of endocrine deficiencies. No correlations were found between pituitary volume and the presence of short stature. The intraclass correlation index (ICC) average for volume was 0.85 [CI95% 0.61-0.94] indicating a good‐to‐excellent correlation of measurements.DiscussionCentral nervous system anomalies are part of the FA phenotype, the most frequent after pituitary hypoplasia being posterior fossa abnormalities, which may have clinical repercussions in the patient. It is therefore necessary to identify those who could be candidates for neurosurgical intervention. The size of the pituitary gland is smaller in these patients, but this does not seem to be related to hormone deficiency and short stature or exposure to a low dose of total body irradiation.
Association of atherogenic index of plasma and triglyceride glucose-body mass index and sarcopenia in adults from 20 to 59: a cross-sectional study
Authors: Pan Ruirong , Wang Tingwei , Tang Ruixue , Qian Zifan 
Published: August 2024

BackgroundThe relationship between atherogenic index of plasma (AIP) and triglyceride glucose-body mass index (TyG-BMI) and sarcopenia has not been studied in the United States (US) population.MethodsThis research included 4,835 people from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018. The relationship between sarcopenia and TyG-BMI, as well as the AIP index, was examined through the utilization of restricted cubic spline (RCS) analysis, subgroup analysis, and multivariate logistic regression analysis. Diagnostic value of AIP and TyG-BMI for sarcopenia was compared by receiver operating characteristic (ROC) curves.ResultsIn this research, 428 people with sarcopenia were identified among the 4,835 subjects that were included in the experiment. AIP and sarcopenia were positively associated with an odds ratio (OR) of 1.58 and a 95% confidence interval (CI) of (1.07, 2.34) on fully adjusted multivariate logistic regression analysis. Similarly, TyG-BMI and sarcopenia were positively associated with an OR of 8.83 and a 95% CI of (5.46, 14.26). AIP and sarcopenia had a non-linear positive connection (P-value&lt;0.001, P-Nonlinear=0.010), while TyG-BMI and sarcopenia had a linear positive correlation (P-value&lt;0.001, P-Nonlinear=0.064), according to RCS analysis. Subgroup analyses showed a significant interaction between TyG-BMI and sarcopenia due to gender (P = 0.023). ROC curves showed that TyG-BMI (AUC:0.738, 95% CI: 0.714 - 0.761) was more useful than AIP (AUC:0.648, 95% CI: 0.622 - 0.673) in diagnosing sarcopenia.ConclusionIn US adults aged 20–59 years, our study revealed a correlation between elevated AIP and TyG-BMI levels and heightened sarcopenia risk. Moreover, TyG-BMI has better diagnostic validity than AIP.
Effect and consequence of the rheological properties of nano Fe2O3-modified drilling muds in the Dibella oil field
Authors: Mahamadou Abdoulaye seyni , Jun Gu , Moctar Maimouna Issa 
Published: August 2024

The development of supportable, cost-effective, and high-performance nanoparticles (NPs) is one of the new examination points within penetrating applications. The consideration of tailorable nanoparticles offers the chance to figure out water-based drilling fluids (WBDFs) with upgraded properties, providing exceptional opportunities in the energy, oil, gas, water, or framework enterprises. In WBDFs, nano and micron materials are investigated to control their rheological properties and their influence. This paper aims to analyze the influence of nano Fe2O3 on the rheological behavior of drilling fluid muds under high temperatures and pressure. Additionally, we seek to identify the optimal concentration of iron oxide nanoparticles that maintain consistent rheology; we examined the interfering effects of shear rates and iron oxide nanoparticle temperature on the shear type of the changed depleting liquid in the Dibella oil field to make the penetrating activity efficient, realistic, and skilled. We observe that as the temperature increases, the water-based mud (WBM), plastic viscosity (PV), yield point (YP), and gel strength (Gs) decrease until the reject structure is disrupted. Therefore, we must proceed with our assessment using nano Fe2O3 to resolve the shortcomings of the slope framework. Six water-based mud cakes containing 0.5, 1, 1.5, 2, 2.5, and 3 g weight percent of iron oxide (Fe2O3) nanoparticles were prepared for this evaluation. The experimental outcomes revealed an optimal nanoparticle mixing of 2.5 g weight percent, which resulted in a 13.8% reduction in the API filtrate volume and a 40% reduction in filter cake thickness. At 300°F temperature and type 10.00 pressure, the results of our experiments consistently demonstrate a decrease of 14.77% in the rheological properties of PV and YP and 10 s and 10 min in the gel strength of carbon oxide nanoparticles. The YP–PV span is 2.7, and the yield strength is 11 lb/100 ft2. On the other hand, mud cake A, which contains 0.5 wt% NPs, loses 6 mL of fluid after 30 min. In contrast, drilling mud cake E, which is composed of 3 wt% NPs, shows a fluid loss of 5.1 mL in the API filter press test. Based on the Bingham plastic model, the maximum shear stress versus shear rate was observed for bentonite drilling muds E and F, with 2.5 wt% and 3 wt% NPs, respectively, and this result indicates that the use of nano Fe2O3 can effectively adjust the properties of drilling fluids.
MicroRNA dysregulation in ataxia telangiectasia
Authors: Cirillo Emilia , Tarallo Antonietta , Toriello Elisabetta , Carissimo Annamaria , Giardino Giuliana , De Rosa Antonio , Damiano Carla , Soresina Annarosa , Badolato Raffaele , Dellepiane Rosa Maria , Baselli Lucia A. , Carrabba Maria , Fabio Giovanna , Bertolini Patrizia , Montin Davide , Conti Francesca , Romano Roberta , Pozzi Elisa , Ferrero Giulio , Roncarati Roberta , Ferracin Manuela , Brusco Alfredo , Parenti Giancarlo , Pignata Claudio 
Published: August 2024

IntroductionAtaxia telangiectasia (AT) is a rare disorder characterized by neurodegeneration, combined immunodeficiency, a predisposition to malignancies, and high clinical variability. Profiling of microRNAs (miRNAs) may offer insights into the underlying mechanisms of complex rare human diseases, as miRNAs play a role in various biological functions including proliferation, differentiation, and DNA repair. In this study, we investigate the differential expression of miRNAs in samples from AT patients to identify miRNA patterns and analyze how these patterns are related to the disease.MethodsWe enrolled 20 AT patients (mean age 17.7 ± 9.6 years old) and collected clinical and genetic data. We performed short non-coding RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) and fibroblasts to compare the miRNA expression profile between AT patients and controls.ResultsWe observed 42 differentially expressed (DE)-miRNAs in blood samples and 26 in fibroblast samples. Among these, three DE-miRNAs, miR-342-3p, miR-30a-5p, and miR-195-5p, were further validated in additional AT samples, confirming their dysregulation.DiscussionWe identified an AT-related miRNA signature in blood cells and fibroblast samples collected from a group of AT patients. We also predicted several dysregulated pathways, primarily related to cancer, immune system control, or inflammatory processes. The findings suggest that miRNAs may provide insights into the pathophysiology and tumorigenesis of AT and have the potential to serve as useful biomarkers in cancer research.
Acute and chronic ocular outcomes in SJS/TEN patients treated with oral ciclosporin vs intravenous immunoglobulin
Authors: Foo Valencia Hui Xian , Yueh Lee Haur , Mehta Jodhbir S. , Ong Hon Shing 
Published: August 2024

Background/AimTo evaluate differences in ocular complications of Stevens Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) patients receiving either systemic IVIG or Ciclosporin (CsA) as initial treatments.MethodsRetrospective review of consecutive patients admitted for SJS/TEN at the Singapore General Hospital (SGH) from 2011 to 2017 who received either IVIG or Ciclosporin at the onset of the disease and had ophthalmological follow-up of at least 6 months were included. Acute ocular severity of SJS/TEN was graded using the Gregory grading score; chronic ocular complications were graded using the Sotozono system.ResultsA total of 18 subjects were included for analysis, with eight in the IVIG group and 10 in the CsA group. There were no significant differences in acute Gregory severity grading between the two groups. The CsA group had a trend towards worse overall chronic Sotozono grading scores compared to the IVIG group (median [IQR]: 2 [0–3] vs. 1 [0–6.5], p = 0.27), with a higher incidence of acute severe cornea involvement (60% vs. 25%, p = 0.93) and chronic corneal and eyelid involvement in the former than the latter. SJS/TEN patients with worse acute ocular involvement were more likely to have TEN and perianal mucosal involvement (50% vs. 0, p = 0.01).ConclusionCompared to those who received IVIG, SJS/TEN patients who received CsA at the acute disease stage, seemed to have worse acute corneal and chronic corneal and eyelid complications. Larger studies are needed to confirm this finding.
A pilot study on the differential urine proteomic profile of subjects with community-acquired acute kidney injury who recover versus those who do not recover completely at 4 months after hospital discharge
Authors: Kaur Harpreet , Kamboj Kajal , Naik Sachin , Kumar Vivek , Yadav Ashok Kumar 
Published: August 2024

BackgroundCommunity-acquired acute kidney injury (CA-AKI) is a sudden structural damage and loss of kidney function in otherwise healthy individuals outside of hospital settings having high morbidity and mortality rates worldwide. Long-term sequelae of AKI involve an associated risk of progression to chronic kidney disease (CKD). Serum creatinine (SCr), the currently used clinical parameter for diagnosing AKI, varies greatly with age, gender, diet, and muscle mass. In the present study, we investigated the difference in urinary proteomic profile of subjects that recovered (R) and incompletely recovered (IR) from CA-AKI, 4 months after hospital discharge.MethodsStudy subjects were recruited from ongoing study of CA-AKI cohort. Patients with either sex or age &gt; 18 years with no underline CKD were enrolled at the time of hospital discharge. Incomplete recovery from CA-AKI was defined as eGFR &lt; 60 mL/min/1.73 m2 or dialysis dependence at 4 months after discharge. Second-morning urine samples were collected, and proteome analysis was performed with LC–MS/MS. Data were analyzed by Proteome Discoverer platform 2.2 (Thermo Scientific) using statistical and various bioinformatics tools for abundance of protein, cellular component, protein class and biological process were analyzed in the recovered and incompletely recovered groups.ResultsA total of 28 subjects (14 in each group) were enrolled. Collectively, 2019 peptides and proteins with 30 high-abundance proteins in the incompletely recovered group (R/IR &lt;0.5, abundance ratio adj. p-value &lt;0.05) and 11 high-abundance proteins in the incompletely recovered group (R/IR &gt;2.0, abundance ratio adj. p-value &lt;0.05) were identified. Tissue specificity analysis, GO enrichment analysis, and pathway enrichment analysis revealed significant proteins in both the groups that are part of different pathways and might be playing crucial role in renal recovery during the 4-month span after hospital discharge.ConclusionIn conclusion, this study helped in identifying potential proteins and associated pathways that are either upregulated or downregulated at the time of hospital discharge in incompletely recovered CA-AKI patients that can be further investigated to check for their exact role in the disease progression or repair.
Physical activity, sedentary behavior, and risk of sepsis: a two-sample mendelian randomization study
Authors: Zhang Yang , Rong Yu , Mao Jun , Zhang Jin , Xiao Wenyan , Yang Min 
Published: August 2024

ObjectiveThis investigation aimed to explore the potential causal relationship between physical activity, sedentary behavior and the risk of sepsis.MethodsUsing a two-sample Mendelian randomization approach, this study evaluated the association between physical activity (including moderate to vigorous physical activity [MVPA], vigorous physical activity [VPA], and accelerometer assessed physical activity) and sedentary behaviors (including television watching, computer use, and driving) with the risk of sepsis. This assessment was based on whole-genome association study data from the UK Biobank and the FinnGen database. Causal inferences were estimated using inverse variance-weighted, weighted median, and MR-Egger methods. Sensitivity analyses were performed using Cochran’s Q test, the MR-Egger intercept test, and the leave-one-out method.ResultsThe risk of sepsis was significantly inversely associated with genetically predicted MVPA (odds ratio [OR] 0.47, 95% confidence interval [CI] 0.24–0.93, P = 0.0296) and VPA alone (OR 0.19, 95% CI 0.04–0.87, P = 0.0324). Conversely, prolonged driving time showed a significant positive association with the risk of sepsis (OR 3.99, 95% CI 1.40–11.40, P = 0.0097).ConclusionThis study provides preliminary evidence of a causal relationship between MVPA and VPA and a reduced risk of sepsis, while prolonged sedentary behaviors such as driving are positively associated with an increased risk of sepsis. These findings provided essential scientific evidence for the development of effective sepsis prevention strategies.
Investigating genomic diversity of Staphylococcus aureus associated with pediatric atopic dermatitis in South Africa
Authors: Ndhlovu Gillian O. N. , Javkar Kiran G. , Matuvhunye Takudzwa , Ngondoh Froodia , Jamrozy Dorota , Bentley Stephen , Shittu Adebayo O. , Dube Felix S. 
Published: August 2024

ImportanceStaphylococcus aureus frequently colonizes the skin and nose of patients with atopic dermatitis (AD), a disease associated with skin barrier dysfunction and chronic cutaneous inflammation. Published genomic studies on AD-associated S. aureus in pediatric populations in sub-Saharan Africa are limited.ObjectivesTo investigate the phenotypic and genomic diversity of S. aureus in children with and without AD during early childhood.Data, setting and participantsA cross-sectional study of 220 children (aged 9–38 months) with AD (cases) and without AD (controls) from Cape Town and Umtata, South Africa.Main outcomes and measuresS. aureus phenotypic and genomic diversity were investigated using whole-genome sequencing, antibiotic susceptibility testing and biofilm microtiter assay.ResultsOf the 124 S. aureus isolates recovered from 220 children, 96 isolates (79 cases and 17 controls) with high-quality sequences were analyzed. Isolates from cases showed greater phenotypic resistance to gentamicin (10%), rifampicin (4%), chloramphenicol (4%), and exhibited multidrug resistance (9%) than in controls. Furthermore, the isolates from cases formed stronger biofilms than those from controls (76% vs. 35%, p = 0.001), but showed no dominance of any virulence factor gene or mobile genetic elements. There was no significant difference in the distribution of immune evasion cluster types between cases and controls. However, IEC type G was identified only among cases.Conclusion and relevanceAD-associated S. aureus has phenotypic and genetic features that are important for successful pathogenic colonization and survival. Further studies are needed to assess the pathological implications of colonization of various S. aureus lineages in vivo to elucidate their pathological contribution to AD pathogenesis and pathophysiology.
The association between dexterity and upper limb impairment during stroke recovery
Authors: Valladares Belen , Kundert Robinson Georg , Pohl Johannes , Held Jeremia P. O. , Luft Andreas R. , Veerbeek Janne Marieke , Branscheidt Meret 
Published: August 2024

IntroductionStroke-induced upper limb disabilities can be characterized by both motor impairments and activity limitations, commonly assessed using Fugl-Meyer Motor Assessment for Upper Extremity (FMMA-UE) and Action Research Arm Test (ARAT), respectively. The relationship between the two assessments during recovery is largely unstudied. Expectedly they diverge over time when recovery of impairment (restitution) plateaus, but compensation-driven improvements still occur. The objective of this study is to evaluate the alignment between FMMA-UE and ARAT in defining upper limb functional recovery categories by ARAT scores. We aimed to establish cut-off scores for both measures from the acute/early subacute, subacute and chronic stages of stroke recovery.MethodsSecondary analysis of four prospective cohort studies (acute/early subacute: n = 133, subacute: n = 113, chronic: n = 92) stages post-stroke. Receiver operating characteristic curves calculated the area under the curve (AUC) to establish optimal FMMA-UE cut-offs based on predefined ARAT thresholds distinguishing five activity levels from no activity to full activity. Weighted kappa was used to determine agreement between the two assessments. We used minimally clinically important difference (MCID) and minimal detectable change (MDC95) for comparison.ResultsFMMA-UE and ARAT scores showed no relevant divergence across all recovery stages. Results indicated similar cut-off scores in all recovery stages with variability below MCID and MDC95 levels. Cut-off scores demonstrated robust AUC values from 0.77 to 0.86 at every recovery stage. Only in highly functional patients at the chronic stage, we found a reduced specificity of 0.55. At all other times sensitivity ranged between 0.68 and 0.99 and specificity between 0.71 and 0.99. Weighted kappa at the acute/early subacute, subacute and chronic stages was 0.76, 0.83, and 0.81, respectively.DiscussionOur research shows a strong alignment between FMMA-UE and ARAT cut-off scores throughout stroke recovery, except among the subgroup of highly recovered patients at the chronic stage. Discrepancies in specificity potentially stem from fine motor deficits affecting dexterity outcomes that are not captured by FMMA-UE. Additionally, the high congruence of both measures suggests they are not suited to distinguish between restitution and compensation. Calling for more comprehensive assessment methods to better understand upper limb functionality in rehabilitation.