bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed surgical debridement in pediatric open fractures: A systematic review and meta-analysis
Authors: Ibrahim Talal , Riaz Muhammad , Hegazy Abdelsalam , Erwin Patricia J. , Tleyjeh Imad M. 
Published: February 2014

Purpose Open fractures are considered orthopedic emergencies that are traditionally treated with surgical debridement within 6 h of injury to prevent infection. However, this proclaimed “6-h rule” is arbitrary and not based on rigorous scientific evidence. The aim of our study was to systematically review the literature that compares late (>6 h from the time of injury) to early (<6 h from the time of injury) surgical debridement of pediatric open fractures. Methods We searched several databases from 1946 to 2013 for any observational or experimental studies that evaluated late and early surgical debridement of pediatric open fractures. We performed a meta-analysis using a random effects model to pool odds ratios for a comparison of infection rates between children undergoing late versus early surgical debridement. We also investigated the infection rates in upper- and lower-limb pediatric open fractures. Descriptive, quantitative, and qualitative data were extracted. Results Of the 12 articles identified, three studies (retrospective cohort studies) were eligible for the meta-analysis, encompassing a total of 714 open fractures. The pooled odds ratio (OR = 0.79) for infection between late and early surgical debridement was in favor of late surgical debridement but was not statistically significant (95 % CI 0.32, 1.99; p = 0.38, I2 = 0 %). No significant difference in infection rate was detected between pediatric open fractures in the upper and lower limbs according to the time threshold in the included studies (OR = 0.72, 95 % CI 0.29, 1.82; p = 0.40, I2 = 0 %). Conclusions The cumulative evidence does not, at present, indicate an association between late surgical debridement and higher infection rates in pediatric open fractures. However, initial expedient surgical debridement of open fractures in children should always remain the rule. Thus, multi-center randomized controlled trials or prospective cohort studies will be able to answer this question with more certainty and a higher level of evidence. Level of evidence Level III.
Stable incidence of surgical treatment and hospitalisation for humeral shaft fractures among 0- to 16-year-old patients in Finland from 1987 to 2010
Authors: Salonen A. , Pajulo O. , Lahdes-Vasama T. , Mattila V. M. 
Published: February 2014

Background Studies among children experiencing fractures report an increasing trend toward operative management. In the present study, we examined whether the same trend has occurred for humeral shaft fractures in accordance with increasing interest toward intramedullary nailing and other operative treatments. The number, incidence and treatment of all hospitalised 0- to 16-year-old patients with humeral shaft fractures in Finland was assessed over a recent 24-year period. Method The study included the entire adolescent (0–16 years) population in Finland during the 24-year period from January 1, 1987, to December 31, 2010. Data on hospitalised patients who sustained humeral shaft fractures were obtained from the nationwide National Hospital Discharge Register (NHDR) of Finland. Results During the study period, there were a total of 1,165 hospitalisations with a main or secondary diagnosis of humeral shaft fracture. The incidence of hospitalisation due to humeral shaft fractures was 4.8 per 100,000 person-years. The incidence increased only slightly among girls from 3.3 per 100,000 person-years in 1987 to 5.3 per 100,000 person-years in 2010. The incidence of reposition and casting was 1.1 per 100,000 person-years and the incidence of reposition with osteosynthesis, including intramedullary nailing, was 1.4 per 100,000 person-years. The specific incidence of intramedullary nailing remained low with no signs of increased incidence, and the incidence was 0.3 per 100,000 person-years. There were no significant changes in the incidence of surgical treatment during the 24-year study period. Conclusion Despite an overall increasing trend toward operative management of fractures in children, conservative management remains the treatment of choice for humeral shaft fractures based on the low and steady incidence of surgical treatment during the 24-year study period. In addition, the incidence of hospitalisation for fractures remained low without a significant increase during the study period.
Report on the 7th international workshop on the CCN family of genes
Authors: Perbal B. , Trackman P. , Castellot J. , Brigstock D. , Takigawa M. , Lau L. , Leask A. 
Published: February 2014

AbstractIn this report, chairs of the 7th International Workshop on the CCN family of Genes, review the progress made in understanding the biological functions of CCN proteins (CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6) with a particular focus on their implications in various pathological conditions, including cancer, fibrosis, diabetes, and cardiovascular diseases.
The Port Clearance Test: Why It Is Important to Clinicians
Authors: Dalton Michael , Pheil Natan , Lacy Jim , Dalton Jordan 
Published: February 2014

Abstract
Understanding proper chamber flushing volume for each port manufacturer and port chamber shape is of value to both clinicians and patients. Failing to follow adequate flushing volumes may lead to sludge buildup and further complications. By sampling the chamber flushing volume of ports of various shapes from different manufacturers, we were able to assess cumulative volume flushing rates using a mixture approximating the viscosity of blood. The data collected highlight the relationship between chamber shape, flushing volume, and flow rate and why it is important that manufacturers recommend adequate flushing volumes specific to each port.
Guidewires Unintentionally Retained During Central Venous Catheterization
Authors: Williams Tamara L. , Bowdle T. Andrew , Winters Bradford D. , Pavkovic Stephen D. , Szekendi Marilyn K. 
Published: February 2014

AbstractBackground: A number of mechanical complications can occur during the insertion of a central venous catheter (CVC), including breakage or loss of the wire and unrecognized failure to remove the wire. Complications related to retention of a guidewire can be serious or fatal.Methods: Incident reports on retained CVC guidewires entered into the University HealthSystem Consortium (UHC) Safety Intelligence Patient Safety Organization (PSO) database (Chicago, IL) over a 5-year period were reviewed to improve our understanding of their circumstances, causes, and related patient outcomes.Findings: A total of 42 events that involved retention of a whole guidewire or a fragment of a wire were found in the UHC Safety Intelligence PSO database from 2008 through 2012. Although one-third of these events were discovered during or at the end of the CVC insertion procedure, retained CVC guidewires were commonly discovered days to years after the procedure and on imaging tests performed for unrelated reasons or during other subsequent care. Managers who reviewed the events commonly recommended education and training to prevent retained CVC guidewires, but factors contributing to these events such as distractions and emergency situations also suggest the need for a device design that prevents the occurrence.Conclusions: Efforts to prevent the loss of CVC guidewires should include clinician education and the development of a device design that prevents inadvertent guidewire loss and alerts clinicians when the end of the guidewire is near.
The case for mistletoe in the treatment of laryngeal cancer
Authors: Shakeel M , Trinidade A , Geider S , Ah-See K W 
Published: February 2014

AbstractIntroduction:Complementary and alternative medicine usage, though rising, remains largely devoid of a sound scientific basis; however, there is increasing evidence to support its use in cancer therapy.Aim:To present the case of a patient with laryngeal carcinoma who made a full recovery following mistletoe therapy, despite failing to respond to chemoradiotherapy and salvage laryngectomy.Design:Case report with relevant literature review.Results:The patient developed extensive, unresectable stomal recurrence, and it was deemed appropriate to supply palliative care only. Following treatment with mistletoe extract injections after palliative radiotherapy, he recovered fully and was eventually discharged from care.Conclusion:The benefit of mistletoe in laryngeal cancer treatment requires further investigation, and might be considered in selected patients, as an adjunct or when other conventional therapies have failed.
The Environmental Rules of Economic Development: Governing Air Pollution from Smelters in Chuquicamata and La Oroya
Authors: ORIHUELA JOSÉ CARLOS 
Published: February 2014

AbstractWhy and how do societies transform the environmental rules of economic development, or fail to do so? This article compares the experiences of Chile and Peru in the regulation of smelting activities between 1990 and 2010. Air pollution from smelters in Chuquicamata and La Oroya, each emblematic of the two countries’ mining industries, did not give rise to nationally destabilising protest. Nevertheless, despite the absence of pressing discontent with pollution, the environmental rules for mining could still be improved as a result of policy network activism and through highly idiosyncratic institutional channels. The analysis shows that policy entrepreneurship for Chuquicamata was enhanced by a national institutional environment that favoured bureaucratic autonomy, while parallel action for La Oroya was constrained by a political economy of state weakness and elite disregard.
The Army of the Andes: Chilean and Rioplatense Politics in an Age of Military Organisation, 1814–1817
Authors: CRUZ JUAN LUIS OSSA SANTA 
Published: February 2014

AbstractThis article analyses the organisation of the Army of the Andes, created in Mendoza between 1814 and 1817 with the aim of reconquering Chile from the royalists. The first section studies the role of José de San Martín as an informal arbiter in Bernardo O'Higgins’ dispute with José Miguel Carrera. The aim is to explain why San Martín decided to support O'Higgins, and the immediate consequences of this alliance. The second section addresses the main characteristics of the Army of the Andes and the process of militarisation experienced by the local inhabitants. Everyday life in Mendoza became inseparable from the needs of the revolutionary army. The paper then considers the so-called guerra de zapa and the participation of irregular agents. The involvement of spies and guerrilla officers in the revolution increased as warfare intensified. The final section analyses the crossing of the cordillera by the insurgents and the revolutionary triumph of 12 February 1817 at Chacabuco.
Controlling invasive species by empowering environmental stakeholders: ecotourism boat operators as potential guardians of wildlife against the invasive American mink
Authors: Fraser Elaine J. , Macdonald David W. , Bryce Rosalind , Lambin Xavier 
Published: February 2014

AbstractPeople who have a stake in their environment are more likely to volunteer to assist conservation but they must be empowered to do so. This study explored the possibility of harnessing volunteers in the control of an invasive predator, the American mink Neovison vison, which decimates seabird colonies in coastal west Scotland. A questionnaire was sent to ecotourism boat operators, a group assumed to have an economic interest in wildlife biodiversity and a stake in their environment, to gauge their opinion on lethal control of American mink. The majority (64%) of respondents were concerned about the presence of mink in their area, agreed with control in principle and were willing to become involved in a volunteer capacity. Respondents who would not volunteer but agreed with control (21%) might reconsider if mink had a visible impact on their local wildlife. The minimum level of support people expected was information on where to get, and how to deploy, monitoring and trapping equipment. This study confirms that people with an intrinsic interest in wildlife consider themselves willing to protect their local biodiversity, with only limited resource input, such as an information pack, from external sources.
The dichotomy between protection and logging of the Endangered and valuable timber speciesAmburana cearensisin north-west Argentina
Authors: Politi Natalia , Rivera Luis , Lizárraga Leónidas , Hunter Malcolm , Defossé Guillermo E. 
Published: February 2014

AbstractAmburana cearensisis a commercially valuable timber species, categorized as Endangered on the IUCN Red List. It is distributed throughout the seasonal dry tropical forests of Brazil, Paraguay, Bolivia, Peru and Argentina. In Argentina it is restricted to the provinces of Salta, where legislation sets a minimum cutting diameter of 60 cm, and Jujuy, where logging of this species has been banned since 1972. The effect of these laws on the species’ conservation status has not been assessed. We estimated species density, using distance sampling methodology, and measured the diameter at breast height of each individual encountered at 13 sites in north-west Argentina. Across both provinces we found a density of 1.12 individuals ha−1(95% CI 0.48–2.63) and there was no significant difference between the density in Salta (5.15 ha−1;; 95% CI 3.14–8.45) and that in Jujuy (3.67 ha−1;; 95% CI 2.59–5.17), although 84% of the individuals encountered in Salta were found at one site. Diameter at breast height was significantly lower in Salta than in Jujuy (23 ± 12 vs 41 ± 18 cm; P < 0.05). These differences in the demography of the species between the provinces may be attributable to the application of different legislation. Our results indicate that it would be prudent to halt logging of this species in Salta until further information is gathered and a sustainable management plan developed.
Depressive symptoms and body mass index: co-morbidity and direction of association in a British birth cohort followed over 50 years
Authors: Geoffroy M.-C. , Li L. , Power C. 
Published: February 2014

BackgroundAn unhealthy body mass index (BMI) has been associated with depression but the direction of association is uncertain. Our aim was to estimate the co-morbidity and direction of association between BMI and depressive symptoms at several ages, from childhood to mid-adulthood.MethodThe data were from 18 558 individuals born in 1 week in March 1958, in England, Scotland and Wales, with follow-up at ages 7, 11, 16, 23, 33, 42, 45 and 50 years. Depression (scores ⩾90th percentile) was identified from child/adolescent (teacher questionnaires) and adult (self-complete questionnaires and clinical interview) measures. BMI (kg/m2) measured in child/adolescence and adulthood was classified as underweight, normal, overweight or obese.ResultsIn cross-sectional analyses, obesity and underweight (not overweight) from 11 to 45 years were associated respectively with 1.3–2.1 and 1.5–2.3 times the risk of depression compared with normal weight. Using the time-lagged generalized estimating equation (GEE) approach, we tested (a) whether underweight or obesity at prior ages (7 to 45 years) predicted subsequent risk of depression (11 to 50 years), adjusting for baseline depression; and (b) whether depression at prior ages (7 to 42 years) predicted subsequent risk of underweight or obesity (11 to 45 years), adjusting for baseline BMI. In longitudinal analyses, underweight predicted subsequent depression in both sexes [odds ratio (OR) 1.25, 95% confidence interval (CI) 1.11–1.40] and depression predicted subsequent underweight in males only (OR 1.84, 95% CI 1.52–2.23). Obesity predicted subsequent depressive symptoms in females only (OR 1.34, 95% CI 1.14–1.56), but depression did not predict obesity.ConclusionsClinicians should consider screening routinely for depression patients with unhealthy BMI, namely underweight and obesity, and vice versa.
Personality change associated with chronic diseases: pooled analysis of four prospective cohort studies
Authors: Jokela M. , Hakulinen C. , Singh-Manoux A. , Kivimäki M. 
Published: February 2014

BackgroundCommon chronic conditions, such as heart disease and cancer, are associated with increased psychological distress, functional limitations and shortened life expectancy, but whether these diseases alter aspects of personality remains unclear.MethodTo examine whether the onset of heart disease, stroke, diabetes, cancer, hypertension, arthritis and respiratory disease is associated with subsequent changes in personality traits of the five-factor model, we pooled data from the Health and Retirement Study, the Midlife in the United States Survey, and the graduate and sibling samples of the Wisconsin Longitudinal Study for an individual-participant meta-analysis (total n = 17 493; mean age at baseline 55.8 years).ResultsAfter adjustment for age, we observed consistent decreases in extraversion [−0.25 T-scores per one disease; 95% confidence interval (CI) −0.40 to −0.10], emotional stability (−0.40, 95% CI −0.61 to −0.19), conscientiousness (−0.44, 95% CI −0.57 to −0.30) and openness to experience (−0.25, 95% CI −0.37 to −0.13) but not in agreeableness (−0.05, 95% CI −0.19 to 0.08) after the onset of chronic diseases. The onset of each additional chronic disease accelerated the average age-related personality change by 2.5 years in decreasing extraversion, 5.5 years in decreasing conscientiousness, and 1.6 years in decreasing openness to experience, and attenuated the increasing levels of emotional stability by 1.9 years. Co-morbid conditions were associated with larger changes than single diseases, suggesting a dose–response association between morbidity and personality change.ConclusionsThese results support the hypothesis that chronic diseases influence personality development in adulthood.
The Roman Marching Camp and Road at Loups Fell, Tebay
Authors: Gethin Bryn , Toller Hugh 
Published: February 2014

AbstractA 15.2-ha Roman marching camp has been identified at the northern end of the Lune gorge where the Roman road northwards from Ribchester emerges into the Eden valley and the Cumbrian plain. The road runs here on an alignment that has not been determined before. The camp lies astride the road and faced east. The remains of the camp and the road are described and discussed.
Impact of vanB vancomycin-resistant enterococcal bacteraemia analysed as a time-varying covariate on length of hospital stay
Authors: CHEAH A. L. Y. , SPELMAN T. , PEEL T. , HOWDEN B. P. , SPELMAN D. , GRAYSON M. L. , NATION R. L. , KONG D. C. M. 
Published: February 2014

SUMMARYThe impact of vanB vancomycin-resistant enterococci (VRE) bacteraemia on length of stay (LOS) in hospital, after adjusting for the time-varying nature of enterococcal bacteraemia (variable onset of bacteraemia post-admission), is unknown. Survival analyses (time-varying Cox and competing risks regression) were performed on vanB VRE bacteraemia patients, matched 1:1 with vancomycin-susceptible enterococci bacteraemia patients to determine the factors associated with LOS in these patients. In Cox regression analysis, vanB VRE bacteraemia, intensive-care-unit admission, Charlson co-morbidity index score ⩾4, and an increase in the time to receive appropriate antibiotics were associated with prolonged LOS. Competing risks regression which accounts for the influence of in-patient mortality on the ability to observe the event discharge alive from hospital suggests that, vanB VRE bacteraemia was not significantly associated with prolonged LOS. For the first time, the rate of discharge from hospital in patients with vanB VRE bacteraemia has been quantified.
The role of guided induction in paper-based data-driven learning
Authors: Smart Jonathan 
Published: February 2014

AbstractThis study examines the role of guided induction as an instructional approach in paper-based data-driven learning (DDL) in the context of an ESL grammar course during an intensive English program at an American public university. Specifically, it examines whether corpus-informed grammar instruction is more effective through inductive, data-driven learning or through traditional deductive instruction. In the study, 49 participants completed two weeks of ESL grammar instruction on the passive voice in English. The learners participated in one of three instructional treatments: a data-driven learning treatment, a deductive instructional treatment using corpus-informed teaching materials, and a deductive instructional treatment using traditional (i.e., non-corpus-informed) materials. Results from pre-test, post-test, and delayed post-test indicated that the DDL group significantly improved their grammar ability with the passive voice, while the other two treatment groups did not show significant gains. The findings from this study suggest that in this learning context there are measurable benefits to teaching ESL grammar inductively using paper-based DDL.
The use of corpus examples for language comprehension and production
Authors: Frankenberg-Garcia Ana 
Published: February 2014

AbstractOne of the many new features of English language learners’ dictionaries derived from the technological developments that have taken place over recent decades is the presence of corpus-based examples to illustrate the use of words in context. However, empirical studies have generally not been able to produce conclusive evidence about their actual worth. In Frankenberg-Garcia (2012a), I argued that these studies – and indeed learners’ dictionaries themselves – do not distinguish sufficiently between examples meant to aid language comprehension and examples that focus on enhancing language production. The present study reports on an experiment with secondary school students carried out to test the usefulness of separate corpus examples for comprehension and production. The results support the need for different types of examples for comprehension and production, and provide evidence in support of data-driven learning, particularly if learners have access to more than one example.
In Situ Cryogenic Transmission Electron Microscopy for Characterizing the Evolution of Solidifying Water Ice in Colloidal Systems
Authors: Tai Kaiping , Liu Yin , Dillon Shen J. 
Published: February 2014

AbstractThe details of ice interface dynamics in complex systems are critical to a variety of natural and commercial processes. A platform for low temperature environmental transmission electron microscopy is developed and applied to characterization of ice crystallization in colloidal solutions. The platform is utilized for studying the phase evolution in ice during crystallization and the dynamic interactions of Au nanoparticles at the crystallization front. The results indicate that models developed to treat ice–particle interactions at the micron scale extend well to the nanoscale.
Effect of Reflux Time on Nanoparticle Shape
Authors: Srivastava Chandan , KVL Sushma 
Published: February 2014

AbstractIn the present work, Pt nanoparticles were produced from a reaction mixture containing a trace amount of cobalt carbonyl salt acting as a shape inducer. Nanoparticle shape evolution during reaction mixture reflux was monitored by characterizing particles extracted from the reaction mixture at different times. It was observed that 5 min of reflux produced spherical nanoparticles, 30 min of reflux produced cube shaped nanoparticles, and 60 min of reflux produced truncated octahedron morphology nanoparticles. It is illustrated that during nanoparticle synthesis the reflux process can provide energy needed for shape transformation from a metastable cube morphology to a truncated octahedron morphology which is thermodynamically the most stable geometry for fcc crystals. An optimization of the reaction reflux is thus needed for isolating metastable shapes.