bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
Authors: Lau Wen Min , Teng Eileen , Chong Hui Shan , Lopez Kirsten Anne Pagaduan , Tay Amy Yuh Ling , Salto-Tellez Manuel , Shabbir Asim , So Jimmy Bok Yan , Chan Shing Leng 
Published: March 2014

AbstractThe surface marker CD44 has been identified as one of several markers associated with cancer stem cells (CSC) in solid tumors, but its ubiquitous expression in many cell types, including hematopoietic cells, has hindered its use in targeting CSCs. In this study, 28 paired primary tumor and adjacent nontumor gastric tissue samples were analyzed for cell surface protein expression. Cells that expressed pan-CD44 were found to occur at significantly higher frequency in gastric tumor tissues. We identified CD44v8-10 as the predominant CD44 variant expressed in gastric cancer cells and verified its role as a gastric CSC marker by limiting dilution and serial transplantation assays. Parallel experiments using CD133 failed to enrich for gastric CSCs. Analyses of another 26 primary samples showed significant CD44v8-10 upregulation in gastric tumor sites. Exogenous expression of CD44v8-10 but not CD44 standard (CD44s) increased the frequency of tumor initiation in immunocompromised mice. Reciprocal silencing of total CD44 resulted in reduced tumor-initiating potential of gastric cancer cells that could be rescued by CD44v8-10 but not CD44s expression. Our findings provide important functional evidence that CD44v8-10 marks human gastric CSCs and contributes to tumor initiation, possibly through enhancing oxidative stress defense. In addition, we showed that CD44v8-10 expression is low in normal tissues. Because CD44 also marks CSCs of numerous human cancers, many of which may also overexpress CD44v8-10, CD44v8-10 may provide an avenue to target CSCs in other human cancers. Cancer Res; 74(9); 2630–41. ©2014 AACR.
Choice and Competition Between Adult Congenital Heart Disease Centers
Authors: Diller Gerhard-Paul , Kempny Aleksander , Piorkowski Adam , Grübler Martin , Swan Lorna , Baumgartner Helmut , Dimopoulos Konstantinos , Gatzoulis Michael A. 
Published: March 2014

Background—
Although concentrating adult congenital heart disease services at high-volume centers has been widely advocated, the potential beneficial effects of competition and patient choice have received relatively little attention. We aimed to assess the degree of patient choice and competition between adult congenital heart disease units and to investigate whether competition indices correlate with clinical quality or research output.

Methods and Results—
Competition between the 10 major adult congenital heart disease units in England was evaluated based on the Herfindahl–Hirschman Index, representing the sum of squared market shares of individual units. In addition, to account for geography and feasible access, we calculated spatial indices of competition based on travel time by road. These indices were correlated with 30-day mortality postpulmonary valve replacement in adult patients (as obtained from the National Central Cardiac Audit Database) and the aggregate research impact factors of individual centers. On a national level, a high level of competition without obvious dominant players was found (Herfindahl–Hirschman Index between 0.107 and 0.013). When accounting for geography, however, important disparities in patient choice and competition faced by individual centers emerged. The degree of local competition was correlated significantly with clinical outcomes and research output. In contrast, no association between center volume and outcome could be established.

Conclusions—
Beyond the usual focus on concentrating services at high-volume centers, the potentially beneficial effects of competition should not be ignored. Therefore, policymakers should consider fostering a competitive environment for adult congenital heart disease centers or at least avoiding creating government-granted monopolies in the field.
Comparison of Electrocardiographic Criteria for the Detection of Cardiac Abnormalities in Elite Black and White Athletes
Authors: Sheikh Nabeel , Papadakis Michael , Ghani Saqib , Zaidi Abbas , Gati Sabiha , Adami Paolo Emilio , Carré François , Schnell Frédéric , Wilson Mathew , Avila Paloma , McKenna William , Sharma Sanjay 
Published: March 2014

Background—
Recent efforts have focused on improving the specificity of the European Society of Cardiology (ESC) criteria for ECG interpretation in athletes. These criteria are derived predominantly from white athletes (WAs) and do not account for the effect of Afro-Caribbean ethnicity or novel research questioning the relevance of several isolated ECG patterns. We assessed the impact of the ESC criteria, the newly published Seattle criteria, and a group of proposed refined criteria in a large cohort of black athletes (BAs) and WAs.

Methods and Results—
Between 2000 and 2012, 1208 BAs were evaluated with history, examination, 12-lead ECG, and further investigations as appropriate. ECGs were retrospectively analyzed according to the ESC recommendations, Seattle criteria, and proposed refined criteria which exclude several specific ECG patterns when present in isolation. All 3 criteria were also applied to 4297 WAs and 103 young athletes with hypertrophic cardiomyopathy. The ESC recommendations raised suspicion of a cardiac abnormality in 40.4% of BAs and 16.2% of WAs. The Seattle criteria reduced abnormal ECGs to 18.4% in BAs and 7.1% in WAs. The refined criteria further reduced abnormal ECGs to 11.5% in BAs and 5.3% in WAs. All 3 criteria identified 98.1% of athletes with hypertrophic cardiomyopathy. Compared with ESC recommendations, the refined criteria improved specificity from 40.3% to 84.2% in BAs and from 73.8% to 94.1% in WAs without compromising the sensitivity of the ECG in detecting pathology.

Conclusion—
Refinement of current ECG screening criteria has the potential to significantly reduce the burden of false-positive ECGs in athletes, particularly BAs.
Assessing the Clinical Effect of Residual Cortical Disconnection After Ischemic Strokes
Authors: Bonilha Leonardo , Rorden Chris , Fridriksson Julius 
Published: March 2014

Background and Purpose—
Studies assessing the relationship between chronic poststroke language impairment (aphasia) and ischemic brain damage usually rely on measuring the extent of brain necrosis observed on MRI. Nonetheless, clinical observation suggests that patients can exhibit deficits that are more severe than what would be expected based on lesion location and size. This phenomenon is commonly explained as being the result of cortical disconnection. To understand whether disconnection contributes to clinical symptoms, we assessed the relationship between language impairments and structural brain connectivity (the connectome) in patients with chronic aphasia after a stroke.

Methods—
Thirty-nine patients with chronic aphasia underwent language assessment and MRI scanning. Relying on MRI data, we reconstructed the individual connectome from T1-weighted and diffusion tensor imaging. Deterministic fiber tractography was used to assess connectivity between each possible pair of cortical Brodmann areas. Multiple linear regression analyses were performed to evaluate the relationship between language performance and cortical necrosis and cortical disconnection.

Results—

We observed that structural disconnection of Brodmann area 45 (spared by the necrotic tissue) was independently associated with naming performance, controlling for the extent of Brodmann area 45 necrosis (
F
=4.62;
P
<0.01; necrosis: β=0.43;
P
=0.03; disconnection β=1.21;
P
<0.001).

Conclusions—
We suggest that cortical disconnection, as measured by the structural connectome, is an independent predictor of naming impairment in patients with chronic aphasia. The full extent of clinically relevant brain damage after an ischemic stroke may be underappreciated by visual inspection of cortical necrosis alone.
Acute Renal Failure Is Associated With Higher Death and Disability in Patients With Acute Ischemic Stroke
Authors: Saeed Fahad , Adil Malik M. , Khursheed Faraz , Daimee Usama A. , Branch Lionel A. , Vidal Gabriel A. , Qureshi Adnan I. 
Published: March 2014

Background and Purpose—
Acute renal failure (ARF) in setting of acute ischemic stroke (AIS) is associated with worse outcome. We sought to determine the prevalence of ARF and effect on outcomes of patients with AIS.

Methods—
Data from all patients admitted to US hospitals between 2002 and 2010 with a primary discharge diagnosis of ischemic stroke and secondary diagnosis of ARF were included. The effect of ARF on rates of intracerebral hemorrhage and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis.

Results—

Of 7 068 334 patients with AIS, 372 223 (5.3%) had ARF during hospitalization. Dialysis was required in 2364 (0.6%) of 372 223 patients. Patients with AIS with ARF had higher rates of moderate to severe disability (41.3% versus 30%;
P
<0.0001), intracerebral hemorrhage (1.0% versus 0.5%;
P
<0.0001), and in-hospital mortality (8.4% versus 2.9%;
P
<0.0001) compared with those without ARF. After adjusting for confounding factors, patients with AIS with ARF had higher odds of moderate to severe disability (odds ratio, 1.3; 95% confidence interval, 1.3–1.4;
P
<0.0001), intracerebral hemorrhage (odds ratio, 1.4; 95% confidence interval, 1.3–1.6;
P
<0.0001), and death (odds ratio, 2.2; 95% confidence interval, 2.0–2.2;
P
<0.0001).

Conclusions—
ARF in patients with AIS is associated with significantly higher rates of moderate to severe disability at discharge and in-hospital mortality.
A Reanalysis of the 1931–43 Atlantic Hurricane Database*
Authors: Landsea Christopher W. , Hagen Andrew , Bredemeyer William , Carrasco Cristina , Glenn David A. , Santiago Adrian , Strahan-Sakoskie Donna , Dickinson Michael 
Published: March 2014

Abstract
A reanalysis of the Atlantic basin tropical storm and hurricane database (“best track”) for the period from 1931 to 1943 has been completed as part of the Atlantic Hurricane Database Reanalysis Project. This reassessment of the main archive for tropical cyclones of the North Atlantic Ocean, Caribbean Sea, and Gulf of Mexico was necessary to correct systematic biases and random errors in the data as well as to search for previously unrecognized systems. Methodology for the reanalysis process for revising the track and intensity of tropical cyclone data is largely unchanged from that of the preceding couple of decades and has been detailed in a previous paper on the reanalysis. Accurate Environmental Forecasting’s numerical weather prediction-based wind field model was utilized here to help determine which states were impacted by various hurricane force winds in several U.S. landfalling major hurricanes during this era. The 1931–43 dataset now includes 23 new tropical cyclones, excludes five systems previously considered tropical storms, makes generally large alterations in the intensity estimates of most tropical cyclones (at various times both toward stronger and weaker intensities), and typically adjusts existing tracks with minor corrections. Average errors in intensity and track values are estimated for both open ocean conditions as well as for landfalling systems. Finally, highlights are given for changes to the more significant hurricanes to impact the United States, Central America, and the Caribbean for this time period.
Assessment of NASA GISS CMIP5 and Post-CMIP5 Simulated Clouds and TOA Radiation Budgets Using Satellite Observations. Part I: Cloud Fraction and Properties
Authors: Stanfield Ryan E. , Dong Xiquan , Xi Baike , Kennedy Aaron , Del Genio Anthony D. , Minnis Patrick , Jiang Jonathan H. 
Published: March 2014

Abstract
Although many improvements have been made in phase 5 of the Coupled Model Intercomparison Project (CMIP5), clouds remain a significant source of uncertainty in general circulation models (GCMs) because their structural and optical properties are strongly dependent upon interactions between aerosol/cloud microphysics and dynamics that are unresolved in such models. Recent changes to the planetary boundary layer (PBL) turbulence and moist convection parameterizations in the NASA GISS Model E2 atmospheric GCM (post-CMIP5, hereafter P5) have improved cloud simulations significantly compared to its CMIP5 (hereafter C5) predecessor. A study has been performed to evaluate these changes between the P5 and C5 versions of the GCM, both of which used prescribed sea surface temperatures. P5 and C5 simulated cloud fraction (CF), liquid water path (LWP), ice water path (IWP), cloud water path (CWP), precipitable water vapor (PWV), and relative humidity (RH) have been compared to multiple satellite observations including the Clouds and the Earth’s Radiant Energy System–Moderate Resolution Imaging Spectroradiometer (CERES-MODIS, hereafter CM), CloudSat–Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO; hereafter CC), Atmospheric Infrared Sounder (AIRS), and Advanced Microwave Scanning Radiometer for Earth Observing System (AMSR-E). Although some improvements are observed in the P5 simulation on a global scale, large improvements have been found over the southern midlatitudes (SMLs), where correlations increased and both bias and root-mean-square error (RMSE) significantly decreased, in relation to the previous C5 simulation, when compared to observations. Changes to the PBL scheme have resulted in improved total column CFs, particularly over the SMLs where marine boundary layer (MBL) CFs have increased by nearly 20% relative to the previous C5 simulation. Globally, the P5 simulated CWPs are 25 g m−2 lower than the previous C5 results. The P5 version of the GCM simulates PWV and RH higher than its C5 counterpart and agrees well with the AMSR-E and AIRS observations. The moister atmospheric conditions simulated by P5 are consistent with the CF comparison and provide a strong support for the increase in MBL clouds over the SMLs. Over the tropics, the P5 version of the GCM simulated total column CFs and CWPs are slightly lower than the previous C5 results, primarily as a result of the shallower tropical boundary layer in P5 relative to C5 in regions outside the marine stratocumulus decks.
Towards Subdaily Rainfall Disaggregation via Clausius–Clapeyron
Authors: Bürger G. , Heistermann M. , Bronstert A. 
Published: March 2014

AbstractTwo lines of research are combined in this study: first, the development of tools for the temporal disaggregation of precipitation, and second, some newer results on the exponential scaling of heavy short-term precipitation with temperature, roughly following the Clausius–Clapeyron (CC) relation. Having no extra temperature dependence, the traditional disaggregation schemes are shown to lack the crucial CC-type temperature dependence. The authors introduce a proof-of-concept adjustment of an existing disaggregation tool, the multiplicative cascade model of Olsson, and show that, in principal, it is possible to include temperature dependence in the disaggregation step, resulting in a fairly realistic temperature dependence of the CC type. They conclude by outlining the main calibration steps necessary to develop a full-fledged CC disaggregation scheme and discuss possible applications.
Investigating Short-Wavelength Correlated Errors on Low-Resolution Mode Altimetry
Authors: Dibarboure G. , Boy F. , Desjonqueres J. D. , Labroue S. , Lasne Y. , Picot N. , Poisson J. C. , Thibaut P. 
Published: March 2014

Abstract
The observation of ocean scales smaller than 100 km with low-resolution mode (LRM) altimetry products is degraded by the existence of a “hump artifact” visible on sea surface height (SSH) spectra.
Through an analysis of simulations and actual data from multiple missions, this paper shows that the hump originates in a response to inhomogeneities in backscatter strength. Current retrackers cannot fit their Brown model properly because they were designed for a scene with homogeneous backscatter properties. The error is also smoothed along track because of the size and shape of the LRM disc-shaped footprint. Therefore, the hump is modulated by the altimeter design and altitude and by the retracker used.
Because of the random nature of the phenomenon, a large majority of long topography segments (e.g., hundreds to thousands of kilometers) is affected. However, within these segments, a substantial fraction of the corruption is contained in small subsets of data (e.g., less than 10%). This paper shows that oceanography users interested in small-scale SSH signals can mitigate the hump corruption by using better editing and postprocessing algorithms on the 20-Hz rate of current products.
Last, the thin stripe-shaped footprint of Cryosat-2’s synthetic aperture radar mode (SARM) is not affected by the hump artifact, thus improving the observation of topography features ranging from 30 to 100 km. The differences between SARM and pseudo-LRM sigma0 can also be used to detect major hump events on pseudo-LRM data, which might be an asset to design/validate a new generation of algorithms aimed at reducing the hump artifact on the existing LRM record.
Seven years of teenage pregnancy in an inner London genitourinary medicine service – a retrospective cohort study
Authors: Hegazi Aseel , Daley Natalie , Williams Elizabeth , McLeod Felicity , Rafiezadeh Saba , Prime Katia 
Published: March 2014

Summary Young people attending genitourinary medicine services are at high risk of unplanned pregnancy. We performed a retrospective cohort study to identify characteristics of pregnant teenagers accessing an inner London genitourinary medicine service. There were 481 pregnancies in 458 teenagers with 54 previous pregnancies and 46 previous terminations of pregnancy. The under-18 and under-16 teenage pregnancy rates were 92.1 and 85.8 per 1000 age-matched clinic attendees, respectively. Median age was 17.1 years. ‘Black Other’ teenagers (‘Black British’, ‘Mixed White-Black Caribbean’ and ‘Mixed White-Black African’) were over-represented, compared to our clinic population, while those of White ethnicity were under-represented. Few pregnancies (1.5%) were planned with the majority (64%) intending terminations of pregnancy. Most teenagers did not use consistent contraception. Two-thirds of patients had attended genitourinary medicine services in the past and sexually transmitted infection prevalence at presentation was high. Effectively targeting the sexual and reproductive health needs of teenage genitourinary medicine clinic attendees may have a significant impact on reducing sexually transmitted infections, unplanned pregnancy and terminations of pregnancy in this group.
Barefoot Running
Authors: Mullen Scott , Cotton Jon , Bechtold Megan , Toby E. Bruce 
Published: March 2014

Background: It has been proposed that running barefoot can lead to improved strength and proprioception. However, the duration that a runner must train barefoot to observe these changes is unknown. Hypothesis: Runners participating in a barefoot running program will have improved proprioception, increased lower extremity strength, and an increase in the volume or size of the intrinsic musculature of the feet. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: In this 8-week study, 29 runners with a mean age of 36.34 years were randomized into either a control group (n = 10) who completed training in their regular running shoes or to an experimental barefoot group (n = 14). Pretraining tests consisted of a volumetric measurement of the foot followed by a strength and dynamic balance assessment. Five subjects completed the pretests but did not complete the study for reasons not related to study outcomes. Participants then completed 8 weeks of training runs. They repeated the strength and dynamic balance assessment after 8 weeks. Results: Significant changes from baseline to 8 weeks were observed within the barefoot group for single-leg hop (right, P = .0121; left, P = .0430) and reach and balance (right, P = .0029) and within the control group for single–left leg hop ( P = .0286) and reach and balance (right, P = .0096; left, P = .0014). However, when comparing the differences in changes from baseline to 8 weeks between the barefoot and control groups, the improvements were not significant at the .05 level for all measures. Conclusion: Although statistically significant changes were not observed between the pre- and posttest evaluations in strength and proprioception with the 8-week low-intensity barefoot running regimen, this does not necessarily mean that these changes do not occur. It is possible that it may take months or years to observe these changes, and a short course such as this trial is insufficient.
Meteorological factors and risk of scrub typhus in Guangzhou, southern China, 2006–2012
Authors: Li Tiegang , Yang Zhicong , Dong Zhiqiang , Wang Ming 
Published: March 2014

AbstractBackgroundScrub typhus is becoming the most common vector born disease in Guangzhou, southern China. In this study, we aimed to examine the effect of weather patterns on the incidence of Scrub typhus in the subtropical city of Guangzhou for the period 2006–2012, and assist public health prevention and control measures.MethodsScrub typhus reported cases during the period of 2006–2012 in Guangzhou were obtained from National Notifiable Disease Report System (NNDRS). Simultaneous meteorological data including temperature, relative humidity, atmospheric pressure, sunshine, and rainfall were obtained from the documentation of the Guangzhou Meteorological Bureau. A negative binomial regression was used to identify the relationship between meteorological variables and scrub typhus.ResultsAnnual incidence rates of scrub typhus from 2006 to 2012 were 3.25, 2.67, 3.81, 4.22, 4.41, 5.12, and 9.75 (per 100 000) respectively. Each 1°C rise in temperature corresponded to an increase of 14.98% (95% CI 13.65% to 16.33%) in the monthly number of scrub typhus cases, while a 1 hPa rise in atmospheric pressure corresponded to a decrease in the number of cases by 8.03% (95% CI −8.75% to −7.31%). Similarly, a 1 hour rise in sunshine corresponded to an increase of 0.17% or 0.54%, and a 1 millimeter rise in rainfall corresponded to an increase of 0.05% or 0.10%, in the monthly number of scrub typhus cases, depending on the variables considered in the model.ConclusionOur study provided evidence that climatic factors were associated with occurrence of scrub typhus in Guangzhou city, China. Temperature, duration of sunshine, and rainfall were positively associated with scrub typhus incidence, while atmospheric pressure was inversely associated with scrub typhus incidence. These findings should be considered in the prediction of future patterns of scrub typhus transmission.