bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direkte Hydroborierung von BB‐Bindungen: eine milde Methode zum Aufbau von BB‐Bindungen
Authors: Braunschweig Holger , Dewhurst Rian D. , Hörl Christian , Phukan Ashwini K. , Pinzner Florian , Ullrich Stefan 
Published: February 2014

AbstractDer präparative Zugang zu elektronenpräzisen Borketten wird durch die bevorzugte Bildung nichtklassischer Strukturen erschwert. Die wenigen bekannten Wege zu solchen Ketten führen über starke Reduktionsmittel oder Übergangsmetallkatalysatoren und haben unterschiedliche Nachteile. Hier berichten wir über die Synthese neuer Furyl‐ und Thienyl‐substituierter Diborene und deren direkte Hydroborierung mit Catecholboran unter Bildung einer B3‐Kette mit einer neuen elektronenpräzisen BB‐Bindung. Die Reaktion ist diastereoselektiv und verläuft unter milden Bedingungen ohne den Einsatz der für die BB‐Kupplung sonst üblichen starken Reduktionsmittel oder Übergangsmetallkatalysatoren.
Low‐Temperature Oxidation of Carbon Monoxide with Gold(III) Ions Supported on Titanium Oxide
Authors: Grünert Wolfgang , Großmann Dennis , Noei Heshmat , Pohl Marga‐Martina , Sinev Ilya , De Toni Andrea , Wang Yuemin , Muhler Martin 
Published: February 2014

AbstractAu/TiO2 catalysts prepared by a deposition–precipitation process and used for CO oxidation without previous calcination exhibited high, largely temperature‐independent conversions at low temperatures, with apparent activation energies of about zero. Thermal treatments, such as He at 623 K, changed the conversion–temperature characteristics to the well‐known S‐shape, with activation energies slightly below 30 kJ mol−1. Sample characterization by XAFS and electron microscopy and a low‐temperature IR study of CO adsorption and oxidation showed that CO can be oxidized by gas‐phase O2 at 90 K already over the freeze‐dried catalyst in the initial state that contained Au exclusively in the +3 oxidation state. CO conversion after activation in the feed at 303 K is due to AuIII‐containing sites at low temperatures, while Au0 dominates conversion at higher temperatures. After thermal treatments, CO conversion in the whole investigated temperature range results from sites containing exclusively Au0.
Preparation of betaine‐modified cationic cellulose and its application in the treatment of reactive dye wastewater
Authors: Ma Wei , Yan Shumin , Meng Mei , Zhang Shufen 
Published: February 2014

ABSTRACTBetaine‐modified cationic cellulose was prepared through the reaction of cellulose with betaine hydrochloride by an efficient one‐step dry method. Dicyandiamide was used as a dehydrating agent to promote the formation of ester bonds between the reactants. Fourier transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy were used to characterize the cellulose betainate. Experiments showed that at a molar ratio of the cellulose glucose unit, betaine hydrochloride to dicyandiamide, of 1:1:0.5 at 150°C for 3 h, the degree of substitution of the cationic group reached 0.80. The adsorption of simulated C. I. Reactive Red 24 and C. I. Reactive Red 195 wastewater on the cationic cellulose was carried out, and the effects of the adsorbent dose, initial dye concentration, and salt concentration on the dye removal efficiency were investigated. The equilibrium adsorption isotherm data of the cationic cellulose exhibited a better fit to the Langmuir isotherm model than the Freundlich one. The experimental results suggest that the prepared cationic cellulose materials show potential application for reactive dye wastewater treatment. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40522.
Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8
Authors: Maier Sarah , Pflüger Tobias , Loesgen Sandra , Asmus Katharina , Brötz Elke , Paululat Thomas , Zeeck Axel , Andrade Susana , Bechthold Andreas 
Published: February 2014

AbstractMensacarcin, a potential antitumour drug, is produced by Streptomyces bottropensis. The structure consists of a three‐membered ring system with many oxygen atoms. Of vital importance in this context is an epoxy moiety in the side chain of mensacarcin. Our studies with different mensacarcin derivatives have demonstrated that this epoxy group is primarily responsible for the cytotoxic effect of mensacarcin. In order to obtain further information about this epoxy moiety, inactivation experiments in the gene cluster were carried out to identify the epoxy‐forming enzyme. Therefore the cosmid cos2, which covers almost the complete type II polyketide synthase (PKS) gene cluster, was heterologously expressed in Streptomyces albus. This led to production of didesmethylmensacarcin, due to the fact that methyltransferase genes are missing in the cosmid. Further gene inactivation experiments on this cosmid showed that MsnO8, a luciferase‐like monooxygenase, introduces the epoxy group at the end of the biosynthesis of mensacarcin. In addition, the protein MsnO8 was purified, and its crystal structure was determined to a resolution of 1.80 Å.
New Aminocoumarins from the Rare ActinomyceteCatenulispora acidiphilaDSM 44928: Identification, Structure Elucidation, and Heterologous Production
Authors: Zettler Judith , Xia Haiyang , Burkard Nadja , Kulik Andreas , Grond Stephanie , Heide Lutz , Apel Alexander K. 
Published: February 2014

AbstractGenome mining led to the discovery of a novel aminocoumarin gene cluster in the rare actinomyceteCatenulispora acidiphilaDSM 44928. Sequence analysis revealed the presence of genes putatively involved in export/resistance, regulation, and biosynthesis of the aminocoumarin moiety and its halogenation, as well as several genes with so far unknown function. Two new aminocoumarins, cacibiocin A and B, were identified in the culture broth ofC. acidiphila. Heterologous expression of the putative gene cluster inStreptomyces coelicolorM1152 confirmed that this cluster is responsible for cacibiocin biosynthesis. Furthermore, total production levels of cacibiocins could be increased by heterologous expression and screening of different culture media from an initial yield of 4.9 mg L−1inC. acidiphilato 60 mg L−1inS. coelicolorM1152. By HR‐MS and NMR analysis, cacibiocin A was found to contain a 3‐amino‐4,7‐dihydroxycoumarin moiety linked by an amide bond to a pyrrole‐2,5‐dicarboxylic acid. The latter structural motif has not been identified previously in any natural compound. Additionally, cacibiocin B contains two chlorine atoms at positions 6′ and 8′ of the aminocoumarin moiety.
Extended follow‐up following “full‐metal jacket” percutaneous coronary interventions with drug‐eluting stents
Authors: Basavarajaiah Sandeep , Naganuma Toru , Latib Azeem , Hasegawa Tasuku , Sharp Andrew , Rezq Ahmed , Sticchi Alessandro , Figini Filipo , Amato Antonio , Colombo Antonio 
Published: February 2014

ObjectivesTo report very long‐term follow‐up of “Full‐Metal Jacket” (FMJ) percutaneous coronary interventions (PCI) in long‐diffuse coronary lesions with drug‐eluting stents (DES).BackgroundPCI for long‐diffuse lesions may result in FMJ, which is not preferred by some operators due to long‐term risk of restenosis and stent thrombosis. The data on long‐term follow‐up of patients with FMJ are limited and would be useful in understanding the safety and feasibility of such a strategy.MethodsBetween April 2002 and March 2007, 274 patients (297 lesions in native coronary arteries) underwent PCI utilizing DES. FMJ was described as lesions requiring ≥ 60 mm of continuous stent. The measured endpoints were cardiac death, target‐vessel myocardial infarction (MI), target lesion revascularization (TLR), target‐vessel revascularization (TVR), and major adverse cardiac events (MACE) defined as composite of cardiac death, target‐vessel MI, and TVR.ResultsThe mean age of patients was 62.1 ± 11 years. The mean length of total stents used was 75.1 ± 16.4 mm (60–150). During the median follow‐up of 74.7 months (interquartile range: 58–96), the rates of cardiac death, MI, TLR, and TVR were: 5.8% (n = 16), 6.2% (n = 17), 27.3% (n = 81), and 30% (n = 89), respectively. The MACE rate was 34%. Definite and probable stent thrombosis occurred in 10 patients (3.6%).ConclusionThe long‐term follow‐up of patients with FMJ is acceptable especially in regards to hard endpoints (death and MI) given the complexity of lesions treated. The high MACE rate was driven mainly by TVR. The availability of newer‐generation DES and bioabsorbable scaffolds may improve these results. © 2014 Wiley Periodicals, Inc.
Electrochemical Co‐Deposition of Phosphonate‐Modified Carbon Nanotubes and Tantalum on Nitinol
Authors: Maho Anthony , Detriche Simon , Fonder Grégory , Delhalle Joseph , Mekhalif Zineb 
Published: February 2014

AbstractNitinol substrates are coated with thin surface films made of carbon nanotubes (CNTs) and tantalum (Ta), with the aim of fostering their osseointegration aptitudes. Exceptional mechanical and chemical characteristics of CNTs combined with the resistance to corrosion and strong bioactive properties of tantalum allow for the generation of adherent, protective and functional layers on metallic biomaterial platforms. The composite coatings are elaborated on Nitinol through a two‐step electrochemical protocol; firstly, through the electrophoretic deposition of phosphonate‐modified CNTs and, secondly, with electrodeposition of Ta. As a preliminary step, phosphonate groups, acting, in addition, as specific Ta‐capture entities, are introduced on the CNT sidewalls by means of diazonium derivatives, which imply no hard oxidative treatment. X‐ray photoelectron spectroscopy as well as scanning and transmission electronic microscopies are used to analyse the chemical composition, structure and morphology of the different layers.
Anhydrous Lanthanide MOFs and Direct Photoluminescent Sensing for Polyoxometalates in Aqueous Solution
Authors: Bo Qi‐Bing , Zhang Hai‐Tao , Wang Hong‐Yan , Miao Jin‐Ling , Zhang Zhen‐Wei 
Published: February 2014

AbstractNew anhydrous lanthanide metal–organic frameworks (MOFs) [Pr(tip)1.5]2n (tip‐Pr), [Nd(tip)1.5]2n (tip‐Nd), [Eu(tip)1.5]2n (tip‐Eu), and [Eu(OH)(mip)]n (mip‐Eu) (tip=5‐tert‐butylisophthalate anion, mip=5‐methylisophthalate ion), have been hydrothermally synthesized and structurally characterized by elemental analyses, FT‐IR spectroscopy, single‐crystal X‐ray diffraction, thermal gravimetric analysis/differential thermal analysis (TG/DTA), and X‐ray powder diffraction (XRPD) techniques. MOFs tip‐Pr, tip‐Nd, and tip‐Eu are isostructural anhydrous compounds, and exhibit an unprecedented 3D microporous structure with hexagonal channel arrays. The selectively prepared MOF mip‐Eu presents an interpenetrated 3D microporous architecture containing the hydroxyl cluster chains. Solid‐state photoluminescence properties at room temperature indicate that both tip‐Eu and mip‐Eu display the characteristic of the Eu3+ ion spectrum dominated by the 5D0→7FJ (J=0‐4) transition. Compared with mip‐Eu, tip‐Eu displays the very high solid‐state quantum yield (0.62±0.03) and longer lifetime value (0.94±0.01 ms), which is due to the absence of the hydroxyl groups from the solid‐state structure of tip‐Eu. More importantly, a new method to directly investigate the potential of solid‐state lanthanide MOFs for ionic sensing in aqueous solutions has been developed, and successfully applied it to study the potential sensing function of tip‐Eu for polyoxometalates (POMs). The possible mechanism for the quenching effect of POMs on the fluorescence of tip‐Eu is elucidated by the strongly competitive absorption of the excited light source energy between POMs and tip ligands. The very promise for the highly sensitive sensing for polyoxometalates, together with the characteristic of the reversible fluorescence response, suggest that solid‐state tip‐Eu can be an excellent candidate for the directly photoluminescent detection of POMs in aqueous solutions.
Evaluation of the pharmacokinetics and pharmacodynamics of two leuprolide acetate 45 mg 6‐month depot formulations in patients with prostate cancer
Authors: Mostafa Nael M. , Chwalisz Kristof , Larsen Lois , Mattia‐Goldberg Cynthia , Spitz Aaron , Pradhan Rajendra S. 
Published: February 2014

AbstractThe pharmacokinetics (PK) and pharmacodynamics of two leuprolide acetate (LA) 45 mg 6‐month depot formulations were characterized in prostate cancer patients. Subjects (planned N = 150 in each cohort) received two intramuscular injections of LA Formulation‐A or Formulation‐B administered 24 weeks apart. Samples were collected for the measurement of testosterone, LH (all subjects) and leuprolide (in a subset of subjects approximately N = 24 in each cohort) at the same time points. Leuprolide PK profile showed an initial peak followed by a rapid decline over the first week post‐dose, with mean leuprolide concentrations staying relatively constant through the end of 24‐week period. Mean testosterone and LH serum concentrations showed initial increases above baseline values after the first dose and then decreased to 16.0 ng/dL and 0.6 mIU/mL by Week 4 for Formulation‐A and were maintained at ≤14.3 ng/dL and 0.4 mIU/mL, thereafter, with negligible mean increases after the second dose. Formulation‐A showed a lower initial peak and higher leuprolide concentration during the sustained release phase which may explain higher testosterone suppression rates for Formulation‐A compared to Formulation‐B. Differences in PK between LA depot formulations were reflected in pharmacodynamic responses, with a higher rate of testosterone suppression and less escapes and acute‐on‐chronic responses for Formulation‐A.
A Phase I cardiac safety and pharmacokinetic study of tivozanib hydrochloride in patients with advanced solid tumors
Authors: Moore Kathleen , Infante Jeffrey R. , Cotreau Monette M. , Wilson Lindsey , Strahs Andrew L. , Vargo Dennis L. , Chadha Manpreet 
Published: February 2014

AbstractTivozanib hydrochloride (tivozanib) is a potent, selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors, with a long half‐life. Tivozanib's effects on the QTc interval in patients with advanced solid tumors were assessed. Patients received 1.5 mg of tivozanib orally, once daily, for 21 days. Safety evaluations, serial blood samples for pharmacokinetic measurements, and time‐matched, triplicate, 12‐lead electrocardiograms (ECG) were collected. Fifty patients were evaluable. The maximum change in QTcF was 9.3 milliseconds (90% confidence interval [CI] 5–13.6), occurring 2.5 hours after dosing on Day 21. The central tendency change across all time points was +2.2 milliseconds. The slope of the exposure–ΔQTcF relationship was 0.08464 ms/ng/mL, with a predicted QTcF change of 8.27 milliseconds at the average tivozanib Tmax of 118.1 ng/mL (upper CI 12.6 milliseconds). There were no QTcF values >500 milliseconds or significant changes from baseline observed in heart rate, PR interval, and QRS complex. These data, evaluated along with other tivozanib preclinical and clinical study results, suggest that administration of 1.5 mg tivozanib for 21 days has a minimal effect on cardiac repolarization or ECG morphology in oncology subjects.
Reliability of high‐resolution electron backscatter diffraction determination of strain and rotation variations using phase‐only and cross correlation
Authors: Riedl T. , Wendrock H. 
Published: February 2014

This contribution analyzes the reliability of strain and rotation variation determination using cross‐ as well as phase‐only correlation of experimental wide‐angle electron backscatter diffraction (EBSD) patterns. For both rotation and three‐point bending the resulting displacement gradient tensor components are examined in terms of magnitude and statistical scatter as a function of various correlation procedure parameters and signal‐to‐noise ratio. It is shown that on the one hand the Fourier filter width has a major impact on the strain results. At higher noise level a smaller filter width has to be applied for obtaining maximum precision. On the other hand, the influence of the degree of overlap of the regions of interest positioned in the patterns is less important. For both rotation and bending experiments the cross‐correlation variant yields a smaller standard deviation with respect to phase‐only correlation, in particular for elevated noise level. The difference is attributed to the stronger propagation of noise effects in the course of phase‐only correlation function calculation and fitting. In the rotation experiment a standard deviation of ∼1.0 × 10−4, averaged over the displacement gradient tensor components, and a rotational precision of ∼1.5 × 10−4 rad have been achieved by using optimized evaluation settings.
Performance evaluation of IEEE 802.15.4 sensor networks in industrial applications
Authors: Du Wan , Navarro David , Mieyeville Fabien 
Published: February 2014

SummaryWireless sensor networks have been widely applied in industrial applications especially since the release of IEEE 802.15.4 standard. By participating in an automobile project in which an IEEE 802.15.4 based sensor and actuator network is deployed to measure and control the vibrations of an automotive system, we need to study many metrics of IEEE 802.15.4 sensor networks (e.g., packet delivery rate, latency, and energy consumption) under various sampling rates. In order to provide detailed modeling of hardware and software as well as network behaviors on each sensor node, we conduct plenty of experiments on a SystemC‐based wireless sensor networks simulator IDEA1, which supports the hardware and software co‐simulation of sensor nodes with certain flexibility of abstraction level. Compared with the existing works on performance evaluation of IEEE 802.15.4 protocols, the main contributions of this paper are the comprehensive studies of both beacon‐enabled and nonbeacon‐enabled modes under various parameter settings and the beacon tracking synchronization mechanism in the IEEE 802.15.4 standard, which is ignored in most previous works. Additionally, the in‐depth analysis of simulation results enables us to find the best parameter configurations to different traffic loads and application requirements, which can be used as general experiences for other applications.Copyright © 2014 John Wiley & Sons, Ltd.
Clinical evaluation, imaging studies, indications for cytologic study, and preprocedural requirements for duct brushing studies and pancreatic FNA: The papanicolaou society of cytopathology recommendations for pancreatic and biliary cytology
Authors: Adler Douglas , Max Schmidt C. , Al‐Haddad Mohammad , Barthel James S. , Ljung Britt‐Marie , Merchant Nipun B. , Romagnuolo Joseph , Shaaban Akram M. , Simeone Diane , Bishop Pitman Martha , Field Andrew , Layfield Lester J. 
Published: February 2014

The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreaticobiliary cytology including indications for endoscopic ultrasound (EUS) and fine‐needle aspiration (FNA) biopsy, techniques for EUS‐FNA, terminology and nomenclature to be used for pancreaticobiliary disease, ancillary testing, and post‐biopsy management. All documents are based on expertise of the authors, literature review, discussions of the draft document at national and international meetings, and synthesis of online comments of the draft document. This document selectively presents the results of these discussions. This document summarizes recommendations for the clinical and imaging work‐up of pancreatic and biliary tract lesions along with indications for cytologic study of these lesions. Prebrushing and FNA requirements are also discussed. Diagn. Cytopathol. 2014;42:325–332. © 2014 Wiley Periodicals, Inc.
Rank perception and self‐evaluation in eating disorders
Authors: Cardi Valentina , Di Matteo Rosalia , Gilbert Paul , Treasure Janet 
Published: February 2014

ABSTRACTObjectivesHeightened sensitivity to social comparison and negative self‐evaluation have been implicated in the development and maintenance of eating disorders (EDs). This study used behavioral tasks, as well as self‐report measures, to examine processing of social rank‐related cues and implicit self‐concept in participants with EDs.MethodFifty healthy participants (HCs), 46 people with an ED, and 22 people recovered from an ED (REC) undertook an attentional bias task using social rank‐related cues and an implicit self‐evaluation task. In addition, they completed self‐report measures of social comparison, submissive behavior, and shame.ResultsPeople with EDs showed vigilance toward social rank‐related stimuli and lower implicit positive self‐evaluation than HCs. Self‐report data confirmed the behavioral findings and showed that people with EDs had higher levels of unfavorable social comparison, submissive behaviors, and external and internal shame than HCs. People who had recovered from an ED showed an intermediate profile between the two groups.DiscussionPeople with EDs have heightened sensitivity to social rank‐related cues and impaired self‐evaluation at an automatic level of processing. Some of these biases remain in people who have recovered. Interventions which aim to remediate social threat sensitivity and negative bias about self and others might be of benefit in EDs. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:543–552)
Thermodynamical Criteria of the Higher Selectivity of Zirconium Oxycations over Hafnium Oxycations towards Organophosphorus Ligands: Density Functional Theoretical Investigation
Authors: Ali Sk. Musharaf 
Published: February 2014

AbstractDensity Functional theory (DFT) has been used to optimize the structures of Cyanex925 [bis(2,4,4‐trimethylpentyl)octylphosphine oxide], tributyl phosphate (TBP), and their complexes with Hf and Zr oxycations by employing the triple‐zeta valence plus polarization (TZVP) basis set. The effect of noncovalent interactions was examined by using the TPSSH and M06‐2X density functionals. The free energy of extraction ΔGextfrom the aqueous to organic phase was calculated by using the standard thermodynamic procedure in conjunction with the conductor‐like screening model (COSMO). The calculated ΔGext, either with an implicit or explicit solvation model, fails to capture the experimentally reported preferential selectivity of ZrO2+ions over HfO2+ions in the absence of nitrate anions towards Cyanex925 over TBP. The presence of nitrate anions along with the second solvation shell (n= 6 + 1 water molecules) around the oxycation shows consistent results with the calculated ΔGextfor the selectivity as reported in solvent extraction experiments [the calculated ΔΔΔGextvalue (–4.72 kcal/mol) is in qualitative agreement with the experimental ΔΔΔGext(–0.82 kcal/mol) results; separation factor (SF) ≈ exp(–ΔΔΔGex/RT)]. Different bonding analyses indicate the electrostatic nature of the interactions between the metal oxycations and the organophosphorus ligands. The present study will further assist in the design of new ligand/solvent systems for the preferential extraction of ZrO2+ions over HfO2+ions in solvent extraction experiments.