bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcranial direct current stimulation and neuronal functional connectivity in MCI: role of individual factors associated to AD
Authors: Kang Dong Woo , Wang Sheng-Min , Um Yoo Hyun , Kim Sunghwan , Kim TaeYeong , Kim Donghyeon , Lee Chang Uk , Lim Hyun Kook 
Published: August 2024

BackgroundAlzheimer’s disease (AD) encompasses a spectrum that may progress from mild cognitive impairment (MCI) to full dementia, characterized by amyloid-beta and tau accumulation. Transcranial direct current stimulation (tDCS) is being investigated as a therapeutic option, but its efficacy in relation to individual genetic and biological risk factors remains underexplored.ObjectiveTo evaluate the effects of a two-week anodal tDCS regimen on the left dorsolateral prefrontal cortex, focusing on functional connectivity changes in neural networks in MCI patients resulting from various possible underlying disorders, considering individual factors associated to AD such as amyloid-beta deposition, APOE ϵ4 allele, BDNF Val66Met polymorphism, and sex.MethodsIn a single-arm prospective study, 63 patients with MCI, including both amyloid-PET positive and negative cases, received 10 sessions of tDCS. We assessed intra- and inter-network functional connectivity (FC) using fMRI and analyzed interactions between tDCS effects and individual factors associated to AD.ResultstDCS significantly enhanced intra-network FC within the Salience Network (SN) and inter-network FC between the Central Executive Network and SN, predominantly in APOE ϵ4 carriers. We also observed significant sex*tDCS interactions that benefited inter-network FC among females. Furthermore, the effects of multiple modifiers, particularly the interaction of the BDNF Val66Met polymorphism and sex, were evident, as demonstrated by increased intra-network FC of the SN in female Met non-carriers. Lastly, the effects of tDCS on FC did not differ between the group of 26 MCI patients with cerebral amyloid-beta deposition detected by flutemetamol PET and the group of 37 MCI patients without cerebral amyloid-beta deposition.ConclusionsThe study highlights the importance of precision medicine in tDCS applications for MCI, suggesting that individual genetic and biological profiles significantly influence therapeutic outcomes. Tailoring interventions based on these profiles may optimize treatment efficacy in early stages of AD.
The efficacy and safety of continuous theta burst stimulation for auditory hallucinations: a systematic review and meta-analysis of randomized controlled trials
Authors: Ye Shi-Yi , Chen Chun-Nuan , Wei Bo , Zhan Jin-Qiong , Li Yi-Heng , Zhang Chen , Huang Jing-Jing , Yang Yuan-Jian 
Published: August 2024

ObjectiveAuditory hallucinations are the most frequently occurring psychotic symptom in schizophrenia. Continuous theta burst stimulation (cTBS) has been used as an adjuvant treatment for auditory hallucinations. This meta-analysis focused on randomized controlled clinical trials (RCTs) to assess the efficacy of adjuvant cTBS on auditory hallucinations in schizophrenia.MethodsWe performed a comprehensive search of four international databases from their inception to January 14, 2024, to identify relevant RCTs that assessed the effects of adjuvant cTBS on auditory hallucinations. The key words included “auditory hallucinations”, “continuous theta burst stimulation” and “transcranial magnetic stimulation”. Inclusion criteria included patients with auditory hallucinations in schizophrenia or schizoaffective disorder. The Revised Cochrane risk-of-bias tool for randomized trials (RoB1) were used to evaluate the risk of bias and the Review Manager Software Version 5.4 was employed to pool the data.ResultsA total of 4 RCTs involving 151 patients with auditory hallucinations were included in the analysis. The Cochrane risk of bias of these studies presented “low risk” in all items. Preliminary analysis showed no significant advantage of adjuvant cTBS over sham stimulation in reducing hallucinations [4 RCTs, n = 151; SMD: -0.45 (95%CI: -1.01, 0.12), P = 0.13; I2 = 61%]. Subgroup analysis revealed that patients treated with adjuvant cTBS for more than 10 stimulation sessions and total number of pulses more than 6000 [3 RCTs, n = 87; SMD: -4.43 (95%CI: -8.22, -0.63), P = 0.02; I2 = 47%] had a statistically significant improvement in hallucination symptoms. Moreover, the rates of adverse events and discontinuation did not show any significant difference between the cTBS and sham group.ConclusionsAlthough preliminary analysis did not revealed a significant advantage of adjuvant cTBS over sham stimulation, subgroup analysis showed that specific parameters of cTBS appear to be effective in the treatment of auditory hallucinations in schizophrenia. Further large-scale studies are needed to determine the standard protocol of cTBS for treating auditory hallucinations.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024534045.
National centralized drug procurement and health care expenditure of households—micro-evidence from CFPS
Authors: Li Xin , Tao Ran , Jin Yuning , Li Na 
Published: August 2024

ObjectiveThis paper utilizes data from the China Family Panel Studies (CFPS) to evaluate the impact of the “4 + 7” National Centralized Drug Procurement (NCDP) on Per Capita Household Health Care Expenditure (PCHHCE).MethodsThe study applies the Differences-in-Differences (DID) methodology to analyze the effects of NCDP. Various robustness tests were conducted, including the Permutation test, Propensity Score Matching, alterations in regression methodologies, and consideration of individual fixed effects.ResultsResearch indicates that the implementation of NCDP led to a reduction of 10.6% in PCHHCE. The results remained consistent across all robustness tests. Additionally, the research identifies diversity in NCDP effects among various household characteristics, with a more significant impact on households residing in rural regions of China, enrolled in Basic Medical Insurance for urban and rural residents and urban workers, and having an income bracket of 25–75%.ConclusionThese findings carry policy implications for the future expansion and advancement of NCDP in China. The study highlights the effectiveness of NCDP in reducing healthcare expenditures and suggests potential areas for policy improvement and further research.
MoveONParkinson: developing a personalized motivational solution for Parkinson’s disease management
Authors: Alves Beatriz , Mota Pedro R. , Sineiro Daniela , Carmo Ricardo , Santos Pedro , Macedo Patrícia , Carreira João Casaca , Madeira Rui Neves , Dias Sofia Balula , Pereira Carla Mendes 
Published: August 2024

IntroductionDespite the effectiveness of exercise-based interventions on symptom management and disease progression, many people with Parkinson’s Disease (PwPD) do not exercise regularly. In line with the ubiquitous use of digital health technology, the MoveONParkinson digital solution was developed, comprising a Web Platform and a Mobile App with a Conversational Agent (CA). The interface features were designed based on the principles of Social Cognitive Theory with the goal of fostering behavior change in PwPD for sustained exercise participation and improved disease management.MethodsUsing a mixed methods approach, this study aimed to collect feedback, assess the acceptability of the Mobile App and the Web Platform, and evaluate the usability of the latter. Quantitative data, which included questionnaire responses and the System Usability Scale (SUS) scores, were analyzed using descriptive statistics, heatmaps, and correlation matrices. Qualitative data, comprising semi-structured and thinking-aloud interview transcripts, were subjected to an inductive thematic analysis. A total of 28 participants were involved in the study, comprising 20 physiotherapists (average age: 34.50 ± 10.4), and eight PwPD (average age: 65.75 ± 8.63; mean Hoehn &amp; Yahr: 2.0 (± 0.76)).ResultsThree main themes emerged from the thematic analysis of the interviews, namely: Self-management (Theme 1), User Engagement (Theme 2), and Recommendations (Theme 3). The assessment of the Mobile App and the CA (mean score: 4.42/5.0 ± 0.79) suggests that PwPD were able to navigate this interface without notable difficulties. The mean SUS score of 79.50 (± 12.40%) with a 95% confidence interval ranging from 73.70 to 85.30, reveal good usability.DiscussionThese findings indicate a high level of acceptability of the MoveONParkinson digital solution, serving as a foundation for assessing its impact on exercise engagement and, subsequently, its influence on symptom management and quality of life of PwPD.
Maximizing farm resilience: the effect of climate smart agricultural adoption practices on food performance amid adverse weather events
Authors: Tunio Raza Ali , Li Dongmei , Khan Nawab 
Published: August 2024

IntroductionGlobal climate change (CC) significantly impacts sustainable food systems and the agricultural sector, primarily through increasing adverse weather events. This study aims to explore the adaptation strategies farmers use to address these challenges and evaluate the effectiveness of climate-smart agricultural (CSA) practices on food performance.MethodsWe collected data from 720 crop farmers located in three provinces of Pakistan using a random sampling method. To address potential biases, this study employed the endogenous switching regression (ESR) model. This model effectively addresses endogeneity and selection bias by considering both observable and unobservable characteristics.ResultsStudy findings indicate that CSA practices substantially enhance net farm returns, reduce volatility, and mitigate downside risks. The analysis also highlights key features affecting the acceptance of CSA practices, including higher education, age, climate information, and availability of agricultural extension services.DiscussionThese insights are essential for policymakers, offering a framework for informed decision-making to tackle CC’s effects on food production, improve living standards, and enhance global food security.
Flow cytometric-based detection of CD80 is a useful diagnostic marker of acute myeloid leukemia in dogs
Authors: Stokol Tracy , Thomas Sophie Isabella , Hoffman Martha , Zhao Shay 
Published: August 2024

IntroductionCD80, a co-stimulatory molecule required for optimal T cell activation, is expressed on antigen-presenting cells, including monocytes and dendritic cells, in dogs and humans. We hypothesized that CD80 would be expressed on tumor cells in dogs from acute myeloid leukemia (AML) but not dogs with lymphoid neoplasms.Methods and resultsWe first evaluated the cellular staining pattern of a hamster anti-murine CD80 antibody (clone 16-10A1, ThermoFisher Scientific Cat# 17–0801-82, RRID: AB_469417) in blood and bone marrow aspirates from healthy dogs. Using flow cytometric analysis and examination of modified Wright’s-stained cytologic smears of unsorted and flow cytometric or immunomagnetic bead-sorted leukocytes, we show that the antibody binds to mature and immature neutrophils and monocytes, but not lymphocytes or eosinophils, in blood and bone marrow. We then added the antibody to routine flow cytometric panels for immunophenotyping hematopoietic neoplasms in dogs. We found that the antibody labeled tumor cells in 72% of 39 dogs with AML and 36% of 11 dogs with acute leukemia expressing lymphoid and myeloid markers (“mixed lineage”) but none of the dogs with B (n = 37) or T (n = 35) lymphoid neoplasms. A higher proportion of tumor cells in dogs with AML were labeled with the anti-CD80 antibody vs antibodies against other myeloid-associated antigens, including CD4 (36%, p = 0.003), CD11b (44%), CD11c (46%), CD14 (38%, p = 0.006) and CD18 (59%, clone YFC118). In contrast, antibodies against CD11b and CD11c bound to tumor cells in 8–32% of the lymphoid neoplasms.DiscussionWe show that CD80, as detected by antibody clone 16-10A1, is a sensitive and specific marker for AML and would be useful to include in flow cytometric immunophenotyping panels in dogs.
Identifying impaired mental health in patients with type 2 diabetes: a cross-sectional study in general practice
Authors: Jakobsen Line T , Søjbjerg Anne , Rasmussen Stinne E , Christensen Kaj S 
Published: August 2024

BackgroundType two diabetes (T2D) is linked to impaired mental health. International guidelines emphasise the importance of including psychological aspects in diabetes care. Yet, no systematic approach has been implemented to assess mental health in patients with T2D in general practice.AimTo evaluate the mental health of patients with T2D in general practice, and to investigate the effectiveness of asking patients about their wellbeing by using a single-item question compared with the five-item World Health Organization-Five Wellbeing Index (WHO-5).Design & settingA cross-sectional study was undertaken, which included 230 patients with T2D in Danish general practice, from 1 May 2023–31 January 2024.MethodEligible patients were recruited at the annual chronic care consultation. They answered a single-item question on wellbeing and four validated measures of general wellbeing (WHO-5), depression (Patient Health Questionnaire-9; PHQ-9), anxiety (Generalised Anxiety Disorder-7; GAD-7), and diabetes distress (Problem Areas in Diabetes-5; PAID-5).ResultsOverall, 32% of patients expressed symptoms of impaired mental health. Notably, the WHO-5 identified 53% of these patients, whereas only 12% of patients were identified through the single-item question. Importantly, among the patients exhibiting symptoms of impaired mental health, those identified by the WHO-5 displayed statistically significantly lower mental health scores across all measures (except PAID-5) compared with those not identified by the WHO-5.ConclusionA significant proportion of patients with T2D in general practice are affected by mental health issues. Our findings indicate that a single-item question may not sufficiently detect these issues, highlighting the importance of incorporating tools, such as the WHO-5, to offer a more comprehensive approach in diabetes care.
Adjusting primary-care funding by deprivation: a cross-sectional study of Lower layer Super Output Areas in England
Authors: Holdroyd Ian , Appel Cameron , Massou Efthalia , Ford John 
Published: August 2024

BackgroundPrevious research has called for general practice funding to be adjusted by deprivation data. However, there is no evidence that this adjustment would better meet clinical need.AimTo assess (1) how accurately the capitation formula (Carr-Hill), and total general practice funding predicts clinical need and (2) whether adjusting by the Index of Multiple Deprivation (IMD) score improves accuracy.Design & settingA cross-sectional analysis of 32 844 Lower layer Super Output Areas (LSOAs) in England in 2021–2022. Sensitivity analysis used data from 2015–2019.MethodWeighted average Carr-Hill Index (CHI), total general practice funding, and five measures of clinical need were calculated for each LSOA. For both CHI and total funding, four sets of generalised linear models were calculated for each outcome measure: unadjusted; adjusted for age; adjusted for IMD; and adjusted for age and IMD. AdjustedR2assessed model accuracy.ResultsIn unadjusted models, CHI was a better predictor than total funding of combined morbidity index (CMI) (R2= 49.81%, 29.31%, respectively), combined diagnosed and undiagnosed morbidity (R2= 43.52%, 21.39%) and emergency admissions (R2= 32.75%, 16.95%). Total funding was a better predictor than CHI of GP appointments per patient (R2= 28.5%, 22.5%, respectively) and age and sex standardised mortality rates (R2= 0.42%, 0.37%). Adjusting for age and IMD improved all 10 models (R2= 62.15%, 53.15%, 48.57%, 38.47%, 40.53%, 32.84%, 29.11%, 34.58%, 25.21%, 25.23%, respectively). All age and IMD adjusted models significantly outperformed age-adjusted models (P<0.001). Sensitivity analysis confirmed findings.ConclusionAdjusting capitation or total funding by IMD would increase funding efficiency, especially for long-term outcomes such as mortality. However, adjusting for IMD without age could have unwanted consequences.
FIRST RESULTS OF MARINE BROADBAND SYNCHRONOUS SEISMIC SURVEY IN THE BARENTS SEA. DATA QUALITY CONTROL
Authors: Потемка А.К. , Колюбакин А.А. , Понимаскин А.И. , Токарев М.Ю. , Бирюков Е.А. , Обметко В.В. , Парамонов Д.В. , Новиков С.С. 
Published: August 2024

Комплексирование геофизических методов для решения сложных геологических задач – широко используемый инструмент при выполнении морских исследований. Расширение частотного диапазона наблюдений при проведении сейсморазведки – одно из важных направлений разработки новых технологий производства работ. Совмещение в рамках одной съемки и одного судна методов нефтегазовой и инженерной сейсморазведки до недавнего времени выглядело нереализуемым и недостаточно обоснованным предложением. Выполненные в полевом сезоне 2023 года в Баренцевом море опытно-промышленные работы по технологии широкополосной синхронной сейсморазведки показали эффективность такого подхода для идентификации опасных геологических процессов и явлений в различных интервалах геологического разреза в рамках геолого-съемочных и поисково-разведочных работ. В данной статье будут рассмотрены результаты контроля качества данных синхронной сейсморазведки и взаимного влияния инженерно-геофизической и нефтегазовой съемок в процессе выполнения полевых работ.
Integrating geophysical methods to solve complex geological problems is a widely used tool in complex marine research. Expanding the frequency range of the signal during seismic exploration is one of the areas in the development of new technologies for work. The combination of oil and gas and engineering seismic exploration methods within one survey and one vessel recently looked like a difficult to implement and insufficiently substantiated proposal, however, pilot work carried out in the 2023 field season in the Barents Sea using broadband synchronous seismic technology showed the effectiveness of this approach for search and identification of dangerous geological processes and phenomena in various intervals of the geological section. This article will consider aspects of quality control of synchronous seismic data and the mutual influence of engineering geophysical and oil and gas surveys during field work.
IDENTIFICATION OF GEOHAZARDS BASED ON GEOPHYSICAL DATA AT THE INITIAL STAGE OF FIELD DEVELOPMENT (MIDDLE CASPIAN)
Authors: Миронюк С.Г. , Росляков А.Г. , Пирогова А.С. , Чегодаева А.Е. 
Published: August 2024

В статье приведены результаты камеральных исследований верхней части геологического разреза по материалам 3D-сейсморазведки МОВ-ОГТ на площади одного из нефтегазоконденсатных месторождений (НГКМ) Среднего Каспия. Работы включали в себя специализированную обработку сейсмических данных, а также интерпретацию с целью получения информации об опасных геологических процессах и явлениях в интервале от дна моря до 1500 м. Специализированная обработка сейсмических данных МОВ-ОГТ проводилась по трем графам для подготовки данных для структурных построений в верхней части разреза, динамического анализа, детального изучения верхней части разреза (вариант «сверхвысокоразрешающей» обработки). В рамках интерпретации были выполнены структурные построения, атрибутный анализ, спектральная декомпозиция, инверсионные преобразования, а также применен кластерный анализ и алгоритмы искусственного интеллекта для типизации отложений и выявления опасных геологических процессов и явлений. В результате было уточнено сейсмогеологическое строение верхней части разреза и получены надежные сведения об опасных геологических процессах и явлениях, распространенных на изучаемой площади. Выявленные геологические опасности были ранжированы по степени риска с учетом интенсивности их проявления и глубины залегания.
The article presents the results of in-house studies of the upper part of the geological section based on the materials of 3D seismic exploration of CDP seismic reflection method on the area of one of the oil and gas condensate fields of the Middle Caspian Sea. The work included specialized processing of seismic data, as well as interpretation in order to obtain information about dangerous geological processes and phenomena in the range from the seabed to 1500 m. The specialized processing of the CDP seismic reflection method seismic data included temporary processing in three graphs for: data preparation for structural constructions in the upper part of the section, dynamic analysis, detailed study of the upper part of the section (a variant of «ultrahigh resolution» processing). As part of the interpretation, structural constructions, attribute analysis, spectral decomposition, inversion transformations were performed, as well as cluster analysis and artificial intelligence algorithms were used to type deposits and identify dangerous geological processes and phenomena.
FEATURES OF THE POSITIONING OF THE RECEIVING-EMITTING SYSTEM DURING THREE-DIMENSIONAL SEISMOACOUSTIC STUDIES
Authors: Бирюков Е.А. , Понимаскин А.И. , Сергеев А.А. , Гайнанов В.Г. 
Published: August 2024

В работе излагается актуальность и важность позиционирования трехмерных высокоразрешающих сейсмоакустических приемоизлучающих систем. Представлены примеры широко востребованных на мировой рынке аналогичных систем, с описание их методов и принципов позиционирования. Так же описаны разработанные авторами подходы и алгоритмы к организации позиционирования отечественного трехмерного комплекса.
This research outlines the relevance and importance of positioning three-dimensional high-resolution seismoacoustic transceiver systems. Examples of similar systems widely in demand on the world market are presented, with a description of their methods and principles of positioning. The approaches and algorithms developed by the authors for organizing the positioning of the Russian three-dimensional complex are also described.
EEG CORRELATES OF PSYCHIC DISTRESS
Authors: Рагозинская В.Г. 
Published: August 2024

Целью исследования явилось изучение особенностей спектральной мощности и когерентности ЭЭГ при психическом дистрессе. Согласно полученным данным, повышение уровня психического дистресса связано со значимым повышением спектральной мощности в высокочастотном бета-диапазоне (от 23 до 36 Гц, считающемся индикатором "занятого мозга") и значимым повышением показателей когерентности во всех частотных диапазонах ЭЭГ (с максимумом в дельта-, тета-, бета2- и бета3-диапазонах). Ключевые слова: электроэнцефалограмма, психический дистресс, спектральный
The aim of the work was to study peculiarities of EEG spectral power and coherence in psychic distress. The research has shown that an increase in the level of mental distress is associated with a significant enhancement of spectral power in beta3 band (23 to 36Hz, considered a "busy brain" indicator) and a significant increase of cortical connectivity in all the bands (with maximum in delta, theta, beta2 and beta3 bands).