bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatitis B reactivation in PsA patients: an SLR and meta-analysis for IL-17, IL-23 and JAK inhibitors
Authors: Androutsakos Theodoros , Dimitriadis Konstantinos , Koutsompina Maria-Loukia , Vassilakis Konstantinos D , Pouliakis Avraam , Fragoulis George E 
Published: August 2024

Abstract

Objectives
HBV reactivation (HBVr) constitutes a side effect of the treatment of autoimmune rheumatic diseases. Even though HBVr risk of conventional synthetic DMARDs (csDMARDs) and anti-tumor necrosis factor (anti-TNF) agents has long been established, the risk of targeted synthetic (ts)DMARDs and anti-interleukin (anti-IL) agents remains largely unknown.

Methods
We conducted a SLR (PubMed, Scopus and EMBASE) and meta-analysis to examine the HBVr risk for the following: anti-IL17, anti-IL12/23, anti-IL23 and JAK-inhibitors in patients with chronic HBV infection (HBsAg presence or detectable HBV-DNA) and in patients with prior HBV infection (HBcAb-positive and HBsAg-negative). Meta-analysis was performed using both the fixed and random effects method and was conducted using the R computing language.

Results
Overall, our study revealed a low HBVr risk of &lt;6% in all agents; the risk was significantly higher for people having chronic compared with those with resolved HBV (14.4% vs 5.1%, respectively P &lt; 0.01). There was no difference among different drugs in the HBVr rates [anti-IL-17: 4% (95% CI: 1–9%), anti-IL-12/IL-23: 2% (95% CI: 0–5%), JAK-inhibitors: 4% (95% CI: 1–8%), anti-IL23: 0%]. Of note, HBVr rate reached 28% in patients with chronic HBV who did not receive anti-viral treatment. For patients with resolved hepatitis, the respective percentage was 4.7%.

Conclusion
Overall, our meta-analysis shows that patients with chronic HBV receiving anti-IL-17, anti-IL-12/23, anti-IL-23 and JAK-inhibitors have significant risk for HBVr, especially if they are not under anti-viral treatment. In contrast, resolved HBV seems to offer minor risk for HBVr even without anti-viral treatment.
Time Won’t Give Me Time: Intersections of Racialized and Gendered Organization of Work in Tech
Authors: Alegria Sharla , Banerjee Pallavi 
Published: August 2024

Abstract
Drawing on theories of gendered and racialized organizations and research on racialization and citizenship, we weave together an intersectional understanding of gendered racial meaning making in tech work. We focus on workers’ control over time, an important point of overlap between gendered and racialized organizations theories. Based on interviews with 85 tech workers who are either U.S. workers or Indian men in the United States with temporary non-immigrant visas (primarily H-1B visas), we examine the organization of work for tech workers with and without visa restrictions, focusing on control over time. We find that permanent U.S. engineers, mostly men, have considerably more control than Indian temporary workers, who have virtually none. U.S. managers have the most control, but because of the perception that they trade schedule control for less technical work, this work is feminized and devalued among engineers. Together, these conditions help to create a lower status, feminized managerial track and lower status, racialized but masculine technical track drafting the Indian workers in racially subordinated masculinity while preserving agency over time and status for technical workers with permanent legal status. These findings allow us to offer an intersectionally grounded revision of the abstract ideal worker concept.
How are differentials understood in economics? Conceptions identified in a textbook analysis
Authors: Feudel Frank , Skill Thomas 
Published: August 2024

Abstract
Differentials are commonly used in economics. However—similarly to other concepts—the way differentials are taught in mathematics courses for economics students might not fit to how they are used in subjects of the students’ major discipline. We therefore investigated by means of a textbook analysis how differentials are used and understood in microeconomics courses, and compared this with the way they are conveyed in mathematics for economics students. This analysis especially shows discrepancies between how differentials are introduced in mathematics and common ways of thinking about differentials in microeconomics, which can hinder students in gaining a holistic picture of the concept. Based on this analysis, we propose consequences for the teaching of differentials in mathematics courses for economics students.
Unveiling intra-population functional variability patterns in a European beech (Fagus sylvatica L.) population from the southern range edge: drought resistance, post-drought recovery and phenotypic plasticity
Authors: Sánchez-Gómez David , Aranda Ismael 
Published: August 2024

Abstract
Understanding covariation patterns of drought resistance, post-drought recovery and phenotypic plasticity, and their variability at the intra-population level are crucial for predicting forest vulnerability to increasing aridity. This knowledge is particularly urgent at the trailing range edge since, in these areas, tree species are proximal to their ecological niche boundaries. While this proximity increases their susceptibility, these populations are recognized as valuable genetic reservoirs against environmental stressors. The conservation of this genetic variability is critical for the adaptive capacity of the species in the current context of climate change. Here we examined intra-population patterns of stem basal growth, gas exchange and other leaf functional traits in response to an experimental drought in seedlings of 16 open-pollinated families within a marginal population of European beech (Fagus sylvatica L.) from its southern range edge. We found a high degree of intra-population variation in leaf functional traits, photosynthetic performance, growth patterns and phenotypic plasticity in response to water availability. Low phenotypic plasticity was associated with higher resistance to drought. Both drought resistance and post-drought recovery of photosynthetic performance varied between maternal lines. However, drought resistance and post-drought recovery exhibited independent variation. We also found intra-population variation in stomatal sensitivity to soil drying, but it was not associated with either drought resistance or post-drought recovery. We conclude that an inverse relationship between phenotypic plasticity and drought resistance is not necessarily a sign of maladaptive plasticity, but rather it may reflect stability of functional performance and hence adaptation to withstand drought. The independent variation found between drought resistance and post-drought recovery should facilitate to some extent microevolution and adaption to increasing aridity. The observed variability in stomatal sensitivity to soil drying was consistent with previous findings at other scales (e.g., inter-specific variation, inter-population variation) that challenge the iso-anisohydric concept as a reliable surrogate of drought tolerance.
Organizational Hierarchies and Export Destinations
Authors: Brambilla Irene , César Andrés , Falcone Guillermo , Porto Guido 
Published: August 2024

Abstract
This paper proposes a new link relating export destinations and the organization of the firm: the production of higher-quality varieties exported to rich destinations induces firms to restructure their production processes, becoming organizationally more complex. A theoretical model with these features is presented and then the mechanisms are explored using a panel of Chilean manufacturing plants. The identification strategy of the paper relies on falling tariffs on Chilean products across destinations caused by the signature of Free Trade Agreements with high-income countries (the European Union, the United States, and South Korea). Results show that Chilean plants that were induced by these tariff reductions to start exporting to high-income destinations increased the number of hierarchical layers and upgraded the quality of their products. This involved the addition of qualified supervisors that facilitated the provision of higher product quality. These effects took place at new high-income exporting firms.
The effects of the atrial natriuretic peptide deficiency on renal cortical mitochondrial bioenergetics in the Dahl SS rat
Authors: Cherezova Alena , Sudarikova Anastasia , Vasileva Valeriia , Iurchenko Regina , Nikiforova Anna , Spires Denisha R. , Zamaro Aleksandra S. , Jones Adam C. , Schibalski Ryan S. , Dong Zheng , Palygin Oleg , Stadler Krisztian , Ilatovskaya Daria V. 
Published: August 2024

AbstractAtrial Natriuretic Peptide (ANP) plays an important role in blood pressure regulation. Low levels of ANP correlate with the development of salt‐sensitive hypertension (SS‐HTN). Our previous studies indicated that ANP deficiency exacerbated renal function decline in SS‐HTN. In the heart and fat tissue, ANP was reported to affect lipid peroxidation and mitochondrial bioenergetics but the effects of ANP on mitochondrial function in the kidney are unexplored. We hypothesized that ANP deficiency in SS‐HTN causes renal bioenergetic shift, leading to disruption of mitochondrial network and oxidative stress. To address the hypothesis, we placed Dahl SS wild‐type (SSWT) and ANP knockout (SSNPPA−/−) rats on 4% NaCl high salt (HS) diet to induce HTN or maintained them on 0.4% NaCl normal salt (NS) diet and assessed mitochondrial bioenergetics and dynamics using spectrofluorimetry, Seahorse assay, electron paramagnetic resonance (EPR) spectroscopy, Western blotting, electron microscopy, PCR and cytokine assays. We report that under high salt conditions, associated with hypertension and renal damage, the SSNPPA−/− rats exhibit a decrease in mitochondrial membrane potential and elevation in mitochondrial ROS levels compared to SSWT. The redox shift is also evident by the presence of more pronounced medullar lipid peroxidation in the SSNPPA−/− strain. We also revealed fragmented, more damaged mitochondria in the SSNPPA−/− rats, accompanied by increased turnover and biogenesis. Overall, our data indicate that ANP deficiency causes disruptions in mitochondrial bioenergetics and dynamics which likely contributes to aggravation of the renal damage and hypertension in the Dahl SS rat; the major pathological effects are evident in the groups subjected to a combined salt and ANP deficiency‐induced mitochondrial stress.
Comparison analysis of the burden and attributable risk factors of early-onset and late-onset colorectal cancer in China from 1990 to 2019
Authors: Gong Mingmin , Xia Tian , Chen Zefu , Zhu Yuanyuan 
Published: August 2024

Objectives
The project intended to analyze the impact of burden and related risk factors of late-onset colorectal cancer (LOCRC) and early-onset colorectal cancer (EOCRC) in China, thus offering essential references for optimizing prevention and control strategies.

Method
Global Burden of Disease Study was employed to describe burden changes of EOCRC and LOCRC in China during 1990–2019, containing the numbers of incidence, deaths, prevalence, and disability-adjusted life years (DALYs), and to compare attributable deaths and DALYs risk factors in varying age and sex segments.

Results
The numbers and corresponding crude rates of incidence, deaths, prevalence, and DALYs of EOCRC and LOCRC in China during 1990–2019 demonstrated an upward trend across all age categories, with males being dramatically predominant. Overall, over time, the impact of a low-calcium diet and a low-fiber diet on mortality and DALY rates decreased, while the impact of other risk factors increased. In terms of gender, the risk factors affecting males changed greatly, with smoking, inadequate milk intake, and the low whole-grain diet being the main factors in 2019, while in 1990, the main factors were the low-calcium diet, smoking, and inadequate milk intake.

Conclusion
The burden of colorectal cancer in China is concerning. Patients grouped by diagnostic age exhibit different characteristics, indicating the need for high-quality research in the future to achieve personalized medicine tailored to different population characteristics.
Influence of network latency and bandwidth on robot-assisted laparoscopic telesurgery: A pre-clinical experiment
Authors: Wang Ye , Ai Qing , Shi Taoping , Gao Yu , Jiang Bin , Zhao Wuyi , Jiang Chengjun , Liu Guojun , Zhang Lifeng , Li Huaikang , Gao Fan , Ma Xin , Li Hongzhao , Zhang Xu 
Published: August 2024

Abstract

Background:
Telesurgery has the potential to overcome spatial limitations for surgeons, which depends on surgical robot and the quality of network communication. However, the influence of network latency and bandwidth on telesurgery is not well understood.

Methods:
A telesurgery system capable of dynamically adjusting image compression ratios in response to bandwidth changes was established between Beijing and Sanya (Hainan province), covering a distance of 3000 km. In total, 108 animal operations, including 12 surgical procedures, were performed. Total latency ranging from 170 ms to 320 ms and bandwidth from 15–20 Mbps to less than 1 Mbps were explored using designed surgical tasks and hemostasis models for renal vein and internal iliac artery rupture bleeding. Network latency, jitter, frame loss, and bit rate code were systemically measured during these operations. National Aeronautics and Space Administration Task Load Index (NASA-TLX) and a self-designed scale measured the workload and subjective perception of surgeons.

Results:
All 108 animal telesurgeries, conducted from January 2023 to June 2023, were performed effectively over a total duration of 3866 min. The operations were completed with latency up to 320 ms and bandwidths as low as 1–5 Mbps. Hemostasis for vein and artery rupture bleeding models was effectively achieved under these low bandwidth conditions. The NASA-TLX results indicated that latency significantly impacted surgical performance more than bandwidth and image clarity reductions.

Conclusions:
This telesurgery system demonstrated safety and reliability. A total of 320 ms latency is acceptable for telesurgery operations. Reducing image clarity can effectively mitigate the potential latency increase caused by decreased bandwidth, offering a new method to reduce the impact of latency on telesurgery.
THE INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE IS NOT RECOMMENDED FOR THE TREATMENT OF LARGE MACULAR HOLES SMALLER THAN 650 µm
Authors: Chen Junhong , Tao Jiwei , Zhang Yun 
Published: August 2024

Purpose:
To compare the anatomical and functional outcomes of the inverted flap technique versus conventional internal limited membrane (ILM) peeling in large idiopathic full-thickness macular holes <650 µm.

Methods:
Retrospective comparative study. Patients with large idiopathic macular holes <650 µm who underwent either the inverted ILM flap technique (IFT) or the ILM peeling were investigated. The main outcomes included the macular hole closure rate, recovery rates of the external limiting membrane and ellipsoid zone, and best-corrected visual acuity at 1, 3, and 6 months postoperatively.

Results:
Sixty-nine eyes of 69 patients who underwent the IFT (n = 32, Group A) or ILM peeling (n = 37, Group B) were included. In both groups, a significant best-corrected visual acuity improvement was acquired throughout the follow-up period. The mean best-corrected visual acuity increased at each follow-up visit in both groups (P < 0.001). However, the IFT group showed poorer visual results than the ILM peeling group at all time points (P = 0.039, 0.005, 0.006). The external limiting membrane recovery rate in the ILM peeling group (78.3%, 29/37 eyes) was higher than that in the IFT group (53.1%, 17/32 eyes) at 6 months after surgery (P = 0.079).

Conclusion:
The IFT resulted in poorer external limiting membrane and visual recovery than ILM peeling, suggesting that the IFT is not a suitable option for repairing large macular holes <650 µm.
COMPARISON OF SURGICAL OUTCOMES OF MACULAR TELANGIECTASIA TYPE 2–ASSOCIATED MACULAR HOLE WITH IDIOPATHIC MACULAR HOLE
Authors: Lee Ji Hye , Kim Joo-Young , Hwang Bo-Een , Kim JU-Young , Kim Rae-Young , Kim Mirinae , Park Young-Gun , Park Young-Hoon 
Published: August 2024

Purpose:
To assess the longitudinal surgical outcomes of macular telangiectasia Type 2 macular hole (MacTel-MH) and compare them with those of idiopathic MH.

Methods:
This retrospective, single-tertiary center study included patients who underwent MH surgery between January 2015 and September 2023. Patients with characteristic optical coherence tomography findings of MacTel in both eyes or those who underwent fluorescence angiography were classified as having MacTel MH. Baseline and postoperative best-corrected visual acuity and optical coherence tomography parameters were reviewed.

Results:
Totally, 27 and 243 eyes with MacTel and idiopathic MH, respectively, were included. Macular hole closure rate was better achieved in idiopathic than in MacTel MH group at two years postoperatively. Temporal recovery of ellipsoid zone and external limiting membrane was more prominent in MacTel than in idiopathic MH group. Statistically significant visual acuity improvement was seen between three months and two years postoperatively in MacTel MH group.

Conclusion:
To the best of our knowledge, this is the first study to analyze the surgical outcomes of MacTel MH in both anatomical and functional aspects and compare them with patients with idiopathic MH. Postoperative microglia change would have affected the restoration of outer retinal layer of patients; however, further studies are needed for clarification.
Frailty Assessment Scale for Heart Failure
Authors: Chao Ying-Cheng , Liu Chieh-Yu , Hung Huei-Fong , Lee Chii-Ming , Hsu Shu-Pen , Chiou Ai-Fu 
Published: August 2024

Background
Frailty is common in patients with heart failure. Specific scales, including the Clinical Frailty Scale, exist but have not undergone thorough psychometric validation among patients with heart failure.

Objective
The aim of this study was to develop and validate the Frailty Assessment Scale for Heart Failure (FAS-HF) in patients with heart failure.

Methods
This study included 3 phases. In phase I, conceptualization and item generation, the FAS-HF was initially developed through the analysis of qualitative research data and a literature review. In phase II, item selection and content validity, the Delphi method was used to gather experts' opinions and suggestions regarding the FAS-HF. In phase III, field testing and psychometric evaluation, a cross-sectional study of 184 patients with heart failure in northern Taiwan was conducted to test the reliability and validity of the FAS-HF.

Results
The 15-item FAS-HF included the physical, psychological, and social frailty domains. The total score ranged from 0 to 45, with higher scores representing frailer individuals. Exploratory factor analysis revealed that the cumulative loading variance was 57.39%. In the confirmatory factor analysis, the goodness-of-fit index (0.91), adjusted goodness-of-fit index (0.87), and root mean square error of approximation (0.06) were acceptable for model fit. Acceptable reliability was found, with a Cronbach α coefficient of 0.87 and a test-retest reliability of 0.99. Compared with the Fried frailty phenotype, the area under the receiver operating characteristic curve was 0.94, and the optimal cutoff score for frailty was 20.

Conclusions
The FAS-HF has good reliability, validity, and discrimination and can be used as a frailty indicator for patients with heart failure.
When Sexual Violence Goes Viral
Authors: Vallée-Ouimet Sandrine , Pariseau-Legault Pierre , Labrecque-Lebeau Lisandre 
Published: August 2024

ABSTRACT
Since the popularization of the #MeToo movement, the prevention and management of sexual violence (SV) has become prominent in North American public discourse, including in the province of Québec (Canada). Despite such an important visibility in the public sphere, there is little scientific evidence of how nursing practice has adapted to the popularization of the #MeToo movement, led by victims of SV. Drawing on critical feminist theories, we describe the results from a literature review on nursing practice in the context of SV on college and university campuses since the #MeToo movement. A literature search was performed in five databases using keywords targeting nursing practice in the context of SV. In total, 45 articles were selected for analysis. Eight studies were added for their relevance (obtained outside the databases). Next, a reflexive thematic analysis inspired by Braun and Clarke (2006) was conducted. The literature review was then used to compare current practices in Québec. The results identify the persistence of numerous myths and stereotypes that contribute negatively to the credibility of persons experiencing SV. The results also describe the difficulty of public institutions to change structures aimed at preventing and managing SV in response to the popularization of the #MeToo movement. The results indicate the relevance of using an intersectional feminist theoretical framework to better understand the complexities of SV. Through our analysis, we show that, more than ever, the evolution of forensic nursing practice must be informed by political and testimonial activism driven by persons experiencing SV.
The Impact of Patients and Student Mental Health Nurses Sharing Time Together in Forensic Units
Authors: Jones Emma S. , Wright Karen M. , McKeown Mick 
Published: August 2024

ABSTRACT
Student mental health nurses have greater patient contact than registered nurses, and this is appreciated by patients. This phenomenological study explored the impact of patients and student mental health nurses' time shared on forensic units for men carrying a personality disorder diagnosis. Phenomenology was the underpinning philosophy of this research. Patients and student mental health nurses in forensic hospitals participated in unstructured hermeneutic interviews. The time students and patients shared together was considered a gift, enabling them to feel that they were “just people” and valued, strongly impacting on their sense of person. The impact the students have on patients' quality of life is meaningful. When the students and patients connected, it had powerful implications for their sense of humanness and value, highlighting the reciprocal impact they each have on another and the importance of having student nurse clinical placements in forensic wards and facilities.
Implications for Clinical Forensic Nursing Practice: This article offers a unique contribution to forensic practice by exploring the experiences of the time patients and students share together in forensic units. Students, who often have the greatest contact with patients, represent the present and future of nursing, and their time is appreciated by patients. Previous research focuses on attitudes and therapeutic relationships, rather than the impact of shared contact. In addition to this, patients in forensic services with personality disorder diagnoses can be the most stigmatized group in mental health care, and exploration of their experiences is lacking. These experiences must be shared.