bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating targets for control of plasmid-mediated antimicrobial resistance in enteric commensals of beef cattle: a modelling approach
Authors: VOLKOVA V. V. , LU Z. , LANZAS C. , GROHN Y. T. 
Published: January 2013

SUMMARYEnteric commensal bacteria of food animals may serve as a reservoir of genes encoding antimicrobial resistance (AMR). The genes are often plasmidic. Different aspects of bacterial ecology can be targeted by interventions to control plasmid-mediated AMR. The field efficacy of interventions remains unclear. We developed a deterministic mathematical model of commensalEscherichia coliin its animate and non-animate habitats within a beef feedlot's pen, with someE. colihaving plasmid-mediated resistance to the cephalosporin ceftiofur. We evaluated relative potential efficacy of within- or outside-host biological interventions delivered throughout rearing depending on the targeted parameter of bacterial ecology. Most instrumental in reducing the fraction of resistant entericE. coliat steer slaughter age were interventions acting on the entericE. coliand capable of either ‘plasmid curing’E. coli, or lowering maximumE. colinumbers or the rate of plasmid transfer in this habitat. Also efficient was to increase the regular replacement of entericE. coli. Lowering replication rate of resistantE. colialone was not an efficient intervention target.
A proposed simulation technique to study the series resistance and related millimeter-wave properties of Ka-band Si IMPATTs from the electric field snapshots
Authors: Acharyya Aritra , Banerjee Suranjana , Banerjee J. P. 
Published: January 2013

A large-signal model and a simulation technique based on non-sinusoidal voltage excitation are used to obtain the electric field snapshots from which the series resistance and related high-frequency properties of a 35 GHz Silicon Single-Drift Region (SDR) Impact Avalanche Transit Time (IMPATT) device have been estimated for different bias current densities. A novel method is proposed in this paper to determine the parasitic series resistance of a millimeter-wave IMPATT device from large-signal electric field snapshots at different phase angles of a full cycle of steady-state oscillation. The method is based on the depletion width modulation of the device under a large-signal condition. The series resistance of the device is also obtained from the large-signal admittance characteristics at threshold frequency. The values of series resistance of a 35 GHz SDR IMPATT diode obtained from the proposed method and the large-signal admittance method are compared with experimentally reported values. The results show that the proposed method provides better and closer agreement with the experimental value.
On the Brink? Intra‐euro Area Imbalances and the Sustainability of Foreign Debt
Authors: Körner Finn Marten , Zemanek Holger 
Published: January 2013

AbstractThis paper analyses the role of financial market credibility shocks from the European Monetary Union accession and the European sovereign debt crisis for diverging current account balances and net foreign debt positions in the euro area. Based on a dynamic general equilibrium model foreign debt positions of European crisis countries are shown to have significantly diverged from a sustainable path. Today, high foreign debt positions prove difficult to reverse given appreciated real exchange rates and high real interest rates. Real depreciations in European crisis countries, while necessary for long‐term crisis resolution, further worsen foreign debt sustainability by raising the real value of debt in the short‐term. To prevent a debt–deflation spiral the real interest burden should be reduced and the real value of debt should be capped.
Determination of Molecular Markers for BRCA1 and BRCA2 Heterozygosity Using Gene Expression Profiling
Authors: Salmon Asher Y. , Salmon-Divon Mali , Zahavi Tamar , Barash Yulia , Levy-Drummer Rachel S. , Jacob-Hirsch Jasmine , Peretz Tamar 
Published: January 2013

Abstract
Approximately 5% of all breast cancers can be attributed to an inherited mutation in one of two cancer susceptibility genes, BRCA1 and BRCA2. We searched for genes that have the potential to distinguish healthy BRCA1 and BRCA2 mutation carriers from noncarriers based on differences in expression profiling. Using expression microarrays, we compared gene expression of irradiated lymphocytes from BRCA1 and BRCA2 mutation carriers versus control noncarriers. We identified 137 probe sets in BRCA1 carriers and 1,345 in BRCA2 carriers with differential gene expression. Gene Ontology analysis revealed that most of these genes relate to regulation pathways of DNA repair processes, cell-cycle regulation, and apoptosis. Real-time PCR was conducted on the 36 genes, which were most prominently differentially expressed in the microarray assay; 21 genes were shown to be significantly differentially expressed in BRCA1 and/or BRCA2 mutation carriers as compared with controls (P &lt; 0.05). On the basis of a validation study with 40 mutation carriers and 17 noncarriers, a multiplex model that included six or more coincidental genes of 18 selected genes was constructed to predict the risk of carrying a mutation. The results using this model showed sensitivity 95% and specificity 88%. In summary, our study provides insight into the biologic effect of heterozygous mutations in BRCA1 and BRCA2 genes in response to ionizing irradiation-induced DNA damage. We also suggest a set of 18 genes that can serve as a prediction and screening tool for BRCA1 or BRCA2 mutational carriers by using easily obtained lymphocytes. Cancer Prev Res; 6(2); 82–90. ©2013 AACR.
Time-Space Discipline of Upper Classes in Global Capitalism: Top Managers, International Artists, and Global Academics—a Comparison
Authors: Gherardi Laura 
Published: January 2013

AbstractOne contribution towards current research into social structures and the relative geometries of power among the TCC in global capitalism can be derived from a form of power—the power over one’s own rhythm and that of others—largely unexplored by existing work. In this article I focus on the link between time-space discipline imposed by production on some fraction of the TCC and their power over time and space of co-workers and subordinates. I introduce some findings obtained from a recent research I carried out on a sample of more than 50 people: top and middle managers of multinationals and, as comparison groups, international artists, global academics, big investors.I will first illustrate, in the footsteps of Thompson and Harvey, the perspective according to which capitalism has always been, in technical terms, a mode of production based on the precise regulation of time and space imposed on those socio-professional groups fitting into the division of labor to different levels and degrees. I will then detail the two declinations of power over rhythm, as they have emerged over the course of my fieldwork. The first declination is autodirect power, expressing the degrees of freedom/subordination in the determination of one’s own time and space, and it has come out of an analysis of the time and space links imposed on those taking part in the research sample. The second declination is power over time and space of others, and has come out from an analysis of the division of labor among their subordinates and co-workers, notably concerning the norm of international geographic mobility in global capitalism.
Early malperfusion, ischemia reperfusion injury, and respiratory failure in acute complicated type B aortic dissection after thoracic endovascular repair
Authors: Xiong Jiang , Zhang Minhong , Guo Wei , Liu Xiaoping , Yin Tai , Jia Xin , Zhang Hongpeng , Xu Yongle , Wang Lijun 
Published: January 2013

Abstract

Background
The aim of this study was to determine the early mortality and major complications of acute complicated type B aortic dissection (ACBD) after thoracic endovascular aortic repair (TEVAR).

Methods
Twenty-six consecutive patients with ACBD who underwent TEVAR were included. Clinical indications before TEVAR and in-hospital mortality and major complications after TEVAR were analyzed and compared with similar reports.

Results
TEVAR was technically successful in all cases. In-hospital mortality occurred in four patients (15%), and major complications occurred in an additional four patients (15%). Three of the four (75%) of the deaths were associated with malperfusion and ischemia reperfusion injury (IRI), and 3/4 (75%) of the major complications were caused by respiratory failure (RF).

Conclusions
In-hospital mortality associated strongly with severe end-organ malperfusion and IRI, while major complications associated with RF, during TEVAR. Our results indicate that malperfusion, IRI and respiratory failure during TEVAR should be carefully monitored and aggressively treated.
Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer
Authors: Antonarakis Emmanuel S. , Heath Elisabeth I. , Smith David C. , Rathkopf Dana , Blackford Amanda L. , Danila Daniel C. , King Serina , Frost Anja , Ajiboye A. Seun , Zhao Ming , Mendonca Janet , Kachhap Sushant K. , Rudek Michelle A. , Carducci Michael A. 
Published: January 2013

Abstract

Background.
The antifungal drug itraconazole inhibits angiogenesis and Hedgehog signaling and delays tumor growth in murine prostate cancer xenograft models. We conducted a noncomparative, randomized, phase II study evaluating the antitumor efficacy of two doses of oral itraconazole in men with metastatic prostate cancer.

Patients and Methods.
We randomly assigned 46 men with chemotherapy-naïve metastatic castration-resistant prostate cancer (CRPC) to receive low-dose (200 mg/day) or high-dose (600 mg/day) itraconazole until disease progression or unacceptable toxicity. The primary endpoint was the prostate-specific antigen (PSA) progression-free survival (PPFS) rate at 24 weeks; a 45% success rate in either arm was prespecified as constituting clinical significance. Secondary endpoints included the progression-free survival (PFS) rate and PSA response rate (Prostate Cancer Working Group criteria). Exploratory outcomes included circulating tumor cell (CTC) enumeration, serum androgen measurements, as well as pharmacokinetic and pharmacodynamic analyses.

Results.
The high-dose arm enrolled to completion (n = 29), but the low-dose arm closed early (n = 17) because of a prespecified futility rule. The PPFS rates at 24 weeks were 11.8% in the low-dose arm and 48.0% in the high-dose arm. The median PFS times were 11.9 weeks and 35.9 weeks, respectively. PSA response rates were 0% and 14.3%, respectively. In addition, itraconazole had favorable effects on CTC counts, and it suppressed Hedgehog signaling in skin biopsy samples. Itraconazole did not reduce serum testosterone or dehydroepiandrostenedione sulfate levels. Common toxicities included fatigue, nausea, anorexia, rash, and a syndrome of hypokalemia, hypertension, and edema.

Conclusion.
High-dose itraconazole (600 mg/day) has modest antitumor activity in men with metastatic CRPC that is not mediated by testosterone suppression.
Model theoretic connected components of finitely generated nilpotent groups
Authors: Bowler Nathan , Chen Cong , Gismatullin Jakub 
Published: January 2013

AbstractWe prove that for a finitely generated infinite nilpotent group G with structure (G, ·, …), the connected component G*0 of a sufficiently saturated extension G* of G exists and equalsWe construct an expansion of ℤ by a predicate (ℤ, +, P) such that the type-connected component is strictly smaller than ℤ*0. We generalize this to finitely generated virtually solvable groups. As a corollary of our construction we obtain an optimality result for the van der Waerden theorem for finite partitions of groups.
Strong tree properties for small cardinals
Authors: Fontanella Laura 
Published: January 2013

AbstractAn inaccessible cardinal κ is supercompact when (κ, λ)-ITP holds for all λ ≥ κ. We prove that if there is a model of ZFC with infinitely many supercompact cardinals, then there is a model of ZFC where for every n ≥ 2 and μ ≥ ℕn, we have (ℕn, μ)-ITP.
Effects of developmental history on the behavioural responses of European starlings(Sturnus vulgaris)to laboratory husbandry
Authors: Jayne K , Feenders G , Bateson M 
Published: January 2013

AbstractThis study examined the impact of rearing environment on the behavioural responses of wild European starlings(Sturnus vulgaris)to standard laboratory husbandry procedures. We compared birds that had been caught from the wild as independent juveniles with birds taken from the nest and hand-reared in the laboratory from approximately ten days post-hatch. Although hand-rearing can increase habituation to humans and hence reduce fearfulness in laboratory birds, in other species maternal deprivation is also associated with increased stress-sensitivity in later life. Thus, the welfare benefits of hand-rearing are unclear. We investigated the interaction between rearing environment (12 hand-reared versus 12 wild-caught birds) and current laboratory housing conditions (enriched versus non-enriched cages and top-level cages versus bottom-level cages) on measures of behaviour before, during and after husbandry. Both wild-caught and hand-reared birds reacted to focal husbandry by moving to the periphery of their cages, indicative of high escape motivation during a stressful procedure. Wild-caught birds were overall less active than hand-reared birds. We found no difference in the response of the wild-caught and hand-reared birds to focal husbandry, but hand-reared birds were faster to resume normal behaviour following husbandry than wild-caught birds when housed in the top cages. We interpret our results as showing evidence for chronic depressive apathy (lower overall activity) coupled with greater fear (longer latencies to resume normal behaviour following husbandry) in the wild-caught birds in some environments. Our data support the conclusion that hand-rearing is associated with some welfare benefits for birds involved in laboratory research.
Dosimetric impact of the respiratory motion of the liver dome in stereotactic body radiotherapy for spine metastasis: A planning study
Authors: Okamoto Hiroyuki , Nonaka Midori , Chiba Takahito , Kaneda Tomoya , Kobayashi Yuta , Nakamura Satoshi , Nakayama Hiroki , Iijima Kotaro , Shuto Yasunori , Yonemura Miki , Oshika Riki , Kishida Hironori , Urago Yuka , Nishitani Masato , Nishina Shuka , Sakamoto Takumi , Shibata Yoshihiro , Goka Tomonori , Igaki Hiroshi 
Published: July 2024

AbstractPurposeThis study aimed to clarify the dosimetric impact of the respiratory motion of the liver on stereotactic body radiation therapy (SBRT) for spine metastasis and examine the utility of introducing beam avoidance (beam‐off at specific gantry angles).MethodsA total of 112 consecutive patients who underwent SBRT for spine metastasis between 2018 and 2024 were examined. Overall, 15 patients who had lesions near the liver dome were included in this study. Retrospective treatment plans were generated using computed tomography (CT) images acquired during inhalation and exhalation to evaluate the dosimetric impact of respiratory motion of the liver. The dose difference (DD) and relative value (DD%) were evaluated using the dose‐volume histogram (DVH) metrics, planning target volume Dmax, D95%, spinal cord D0.035 cc, and esophagus D2.5 cc. The magnitude of the liver movements was evaluated based on differences of liver size Lave at the isocentric axial plane between the inspiratory and expiratory CT images.ResultsThe DD in almost all DVH metrics tended to increase when the liver moved away from the target during inhalation: For example, Mean a standard deviation (SD) DD in PTV D95% for the treatment plan incorporating beam avoidance and those without beam avoidance was 0.5 0.3 and 0.9 0.6 Gy, respectively. The spinal cord D0.035 cc for those shows 0.4 0.2 and 0.7 0.7 Gy, respectively. The treatment plans without beam avoidance also showed moderate or strong correlations between Lave and DD for almost all DVH metrics. No correlation was seen in the beam avoidance plan. The spinal cord D0.035 cc revealed approximately 1 Gy or +4% in DD when Lave was < −4 cm.ConclusionsRespiratory motion of the liver dome can cause substantial dosimetric discrepancies in the dose delivered to the spinal cord, although the extent depends on patient variables. Dose assessment should be performed for determining the appropriate means of respiratory management, such as breath‐hold. Alternatively, beam avoidance effectively mitigates the impact.
Duration of Postvaccination Neutralizing Antibodies to SARS‐CoV‐2 and Medication Effects: Results from the Safety and Immunogenicity of COVID‐19 Vaccination in Systemic Immune‐Mediated Inflammatory Diseases Cohort Study
Authors: Habib Rami , Dayam Roya M. , Hitchon Carol , Chandran Vinod , Fortin Paul R. , Boire Gilles , Bowdish Dawn M. E. , Gingras Anne‐Claude , Flamand Louis , Larché Maggie J. , Colmegna Ines , Lukusa Luck , Lee Jennifer L. F. , Pereira Daniel , Bernstein Charles N. , Lalonde Nadine , Turnbull Elizabeth , Bernatsky Sasha ,   SUCCEED investigative team
Published: July 2024

ObjectiveIn the face of the ongoing circulation of SARS‐CoV‐2, the durability of neutralization post–COVID‐19 vaccination in immune‐mediated inflammatory disease (IMID) is a key issue, as are the effects of medications.MethodsAdults (n = 112) with inflammatory bowel disease, psoriasis/psoriatic arthritis, rheumatoid arthritis, spondylarthritis, and systemic lupus were recruited from participating Canadian medical centers from 2021 to 2023. We focused on log‐transformed neutralization (lentivirus methods) as a continuous outcome, with separate models for wild‐type and Omicron strains BA.1 and BA.5.ResultsCompared with 30 to 120 days postvaccination, subsequent periods were associated with greater neutralization in unadjusted models for wild‐type, BA.1, and BA.5 strains and against the BA.1 strain in adjusted models. Rituximab was associated with lower neutralization for the BA.1 strain in adjusted models, with a similar trend for BA.5. In methotrexate users, there were trends for less neutralization of BA.1 and BA.5 in all unadjusted models, whereas in adjusted models, there was significantly lower neutralization only for the wild type. Three or more doses and Omicron‐specific vaccines were both independently associated with better neutralization ability for all three strains. A COVID‐19 infection within six months before sampling was associated with higher neutralization of wild type and BA.1 in adjusted analyses. Anti–tumor necrosis factor agents were associated with lower neutralization ability for BA.5 in adjusted analyses.ConclusionNeutralization responses in immunosuppressed individuals with IMID were durable over time and were augmented by more than three doses and Omicron‐specific vaccines. Less neutralization was seen with certain medications. Our work clarifies the joint effects of vaccine history, infection, and medications on COVID‐19 immunity.
Site‐Selective MoS2‐Based Sensor for Detection and Discrimination of Triethylamine from Volatile Amines Using Kinetic Analysis and Machine Learning
Authors: Gaur Snehraj , Singh Sukhwinder , Deb Jyotirmoy , Bhutani Vansh , Mondal Rajkumar , Pareek Vishakha , Gupta Ritu 
Published: July 2024

AbstractDetection and discrimination of volatile organic compounds (VOCs) is important to provide a more realistic assessment of their potential implication in complex environments and medical diagnostics based on volatile biomarkers. Herein, chemiresistive sensors are fabricated using stacked MoS2 nanoflakes with defects and exposed‐edge sites. The sensor is found to be extremely selective to triethylamine (TEA) over polar, non‐polar VOCs and atmospheric gases. The sensor exhibits a sensitivity of 1.72% ppm−1, fast response/recovery (19 s/39 s) to 100 ppm TEA at room temperature, low limit of detection (64 ppb), device reproducibility, humidity tolerance (RH 90%) and stability tested up to 60 days. The kinetic analysis of sensing curves reveals two discrete adsorption sites corresponding to edge and basal sites of interaction, with a higher rate constant of association and dissociation for TEA. The Density Functional Theory (DFT) studies support higher adsorption energy of TEA on MoS2 surface with respect to other volatile amines. The sensor demonstrates TEA recognition and composition estimation capability in a binary mixture of a similar class of VOCs using Machine Learning driven analysis with 95% accuracy. The ability to discriminate amines in binary mixture of other volatile amines paves the way for the advancement of next‐generation devices in the field of disease diagnosis.
A Facile In Situ Sulfurization Strategy for Heterostructured SnS2@Graphene Scrolls Anode with Enhanced Initial Coulombic Efficiency for High‐Energy Lithium Storage
Authors: Zhu Chengyu , Mao Jianjiang , Zhao Jinyang , Luo Yuhong , Li Jingde , Lei Cheng , Li Gang , Cheng Fei 
Published: July 2024

AbstractThe initial Coulombic efficiency (ICE) for anode materials is usually one of important parameters for the energy density improvement of batteries. However, due to the lack of effective regulatory methods, the excellent ICE is usually difficult to achieve for SnS2 systems based on alloying/conversion mechanisms in Li‐storage process. Herein, a heterostructure constructed from SnS2 nanoflakes in situ anchored on graphene scroll (SnS2@GS) is engineered and fabricated involving a facile in situ sulfurization strategy. The SnS2@GS anode benefiting from 1D open and organized ion diffusion pathways, along with rapid charge transfer in the heterogeneous interfaces, achieves improved reversibility and kinetics. This material exhibits a remarkable specific capacity coupled with a high ICE (≈88%) while yielding robust rate properties. These exceptional lithium storage properties derive from improved conductivity and reduced energy barriers for Li‐ion migration in the heterostructures, as indicated by the density functional theory calculations. Besides, the full‐cell (LiFePO4//SnS2@GS) and the lithium‐ion capacitor based on SnS2@GS anode are assembled and deliver superior energy densities of 330 and 349 W h kg−1, respectively. This proposed approach is also popularized for the fabrication about other metal sulfide wrapped in graphene scroll to construct the anodes with remarkable properties.