bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observational study of the relationship between volume and outcomes using data from the National Audit of Cardiac Rehabilitation
Authors: Doherty Patrick , Harrison Alexander S , Knapton Mike , Dale Veronica 
Published: November 2015

ObjectiveCardiac rehabilitation (CR) is an evidence-based intervention delivered by a wide range of high-volume and low-volume centres; however, the extent of volume–outcome relationship is yet to be studied. There is a lack of consensus about the effect of volume on outcomes, with evidence of mixed effects in acute and chronic care. The aim of this study is, to investigate the extent of association of outcomes in CR with patient volume.MethodsData was validated and extracted from the national audit from 2012 to 2013 for each CR centre. Volume was calculated as the total number of patients entering outpatient CR. Hierarchical multiple regression models were used to test for relationships between volume and outcomes. The outcomes included body mass index, blood pressure, psychosocial well-being, cholesterol, smoking cessation and physical activity. The analyses were adjusted for centre and patient characteristics and confounders.ResultsThe number of patients included in the volume analysis was 48 476, derived from 178 CR centres. The average age per centre was 66 years with a 70% male distribution of patients enrolled. Regression analysis revealed no volume–outcome relationship, additionally no statistical significance existed.ConclusionsUnlike cardiac surgery this study, after accounting for staffing, age, gender and comorbidity, shows no effect of volume on outcome following CR delivered by high-volume and low-volume programmes. Based on our data there is no support for centralisation of services. Our findings and methodology can be used as a benchmark for future volume–outcome relationship studies in CR.
InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma
Authors: Ma Yufang , Tang Nan , Thompson Reid C. , Mobley Bret C. , Clark Steven W. , Sarkaria Jann N. , Wang Jialiang 
Published: November 2015

Abstract
Purpose: Aberrant activation of EGFR is a hallmark of glioblastoma. However, EGFR inhibitors exhibit at best modest efficacy in glioblastoma. This is in sharp contrast with the observations in EGFR-mutant lung cancer. We examined whether activation of functionally redundant receptor tyrosine kinases (RTKs) conferred resistance to EGFR inhibitors in glioblastoma.
Experimental Design: We collected a panel of patient-derived glioblastoma xenograft (PDX) lines that maintained expression of wild-type or mutant EGFR in serial xenotransplantation and tissue cultures. Using this physiologically relevant platform, we tested the abilities of several RTK ligands to protect glioblastoma cells against an EGFR inhibitor, gefitinib. Based on the screening results, we further developed a combination therapy cotargeting EGFR and insulin receptor (InsR)/insulin-like growth factor 1 receptor (IGF1R).
Results: Insulin and IGF1 induced significant protection against gefitinib in the majority of EGFR-dependent PDX lines with one exception that did not express InsR or IGF1R. Blockade of the InsR/IGF1R pathway synergistically improved sensitivity to gefitinib or dacomitinib. Gefitinib alone effectively attenuated EGFR activities and the downstream MEK/ERK pathway. However, repression of AKT and induction of apoptosis required concurrent inhibition of both EGFR and InsR/IGF1R. A combination of gefitinib and OSI-906, a dual InsR/IGF1R inhibitor, was more effective than either agent alone to treat subcutaneous glioblastoma xenograft tumors.
Conclusions: Our results suggest that activation of the InsR/IGF1R pathway confers resistance to EGFR inhibitors in EGFR-dependent glioblastoma through AKT regulation. Concurrent blockade of these two pathways holds promise to treat EGFR-dependent glioblastoma. Clin Cancer Res; 22(7); 1767–76. ©2015 AACR.
Solid cancers after antiplatelet therapy: Confirmations, controversies, and challenges
Authors: Cherepanov Vasily , Cabrera-Fuentes Hector A. , Kim Moo Hyun , Serebruany Victor L. 
Published: November 2015

SummaryThe role of anticoagulants and antiplatelet agents in tumour growth and prognosis is not new, and currently under intense investigation. Some randomised data strongly suggest that this association exists, but it is complex, and not necessarily pointed at the same direction. The potential mechanisms responsible for such harmful association include a direct hazard of novel antithrombotics on cancer, indirect promotion of tumour growth, easier metastatic dissemination due to instability of platelet-tumour cell aggregates, or/and inability to keep cancer cells locally in situ are considered. The latest randomised evidence ultimately rejected the drug-specific cancer risks, clearly indicating the class-effect. In lay terms “cancers follow bleeding”, which seems to be true for antithrombotic agents in general. Significant excess of solid cancers which was similar after prasugrel in TRITON, and with vorapaxar in TRACER trials was confirmed by the FDA reviews. Later, extra cancer deaths reported following clopidogrel and prasugrel in DAPT, and after ticagrelor in PEGASUS are also of concern. However, there are remaining controversies with regard to published cancer risks after ticagrelor (PLATO), or another vorapaxar trial (TRA2P), while full disclosure of separate clopidogrel and prasugrel cancer data in DAPT is still lacking. In short, if we apply moderate antiplatelet strategies for over two years, or aggressive regimens including triple therapy for much less than one year, the solid cancer risks emerge. Currently, more delicate platelet inhibition, and shorter exposure to dual oral antiplatelet agents should prevail.
Estimating Toronto’s health services use for the 2015 Pan American and Parapan American Games
Authors: Feldman Laura Y , Gao Chenwei , Zhu Jingqin , Simatovic Jacqueline , Licskai Christopher , To Teresa 
Published: November 2015

Aims: Ambient air temperature may exacerbate the burden of chronic diseases on Ontario’s healthcare system during mass gathering events. This study aimed to estimate the impact of increasing temperature in July and August on health services use for chronic conditions in Ontario’s Golden Horseshoe region during the 2015 Pan American and Parapan American Games, using environmental and health administrative data from previous years. Method: Negative binomial regression was used to calculate incidence risk ratios for same-day health services use (hospitalisations, emergency department visits, physician office visits) for all causes, asthma, asthma-related conditions, diabetes and hypertension associated with unit increases in daily maximum temperature from 1 May to 31 August in 2008–2010. Sensitivity analysis was performed to estimate the added burden of an increased population size, in order to model an influx of visitors during the Games. Results: In July and August, on days with daily maximum temperatures of 35°C compared to 25°C, we estimated seeing 7,827 more physician office visits for all causes in Ontario’s Golden Horseshoe region. The estimated relative increase in physician office visits for diabetes due to temperature alone was 8.4%. With an estimated 10% increase in population, the increase in physician office visits for all causes tripled to an estimated 23,590. Conclusion: Temperature was identified as a potential contributor to greater health services use during the Games, particularly for those living with diabetes. These results highlight the importance of strategic delivery of health services during mass gathering events, and suggest a role for educating at-risk individuals on prevention behaviours, particularly on very hot days.
The Exact Distribution of the Hansen–Jagannathan Bound
Authors: Kan Raymond , Robotti Cesare 
Published: November 2015

Under the assumption of multivariate normality of asset returns, this paper presents a geometric interpretation and the finite-sample distributions of the sample Hansen–Jagannathan bounds on the variance of admissible stochastic discount factors, with and without the nonnegativity constraint on the stochastic discount factors. In addition, since the sample Hansen–Jagannathan bounds can be very volatile, we propose a simple method to construct confidence intervals for the population Hansen–Jagannathan bounds. Finally, we show that the analytical results in the paper are robust to departures from the normality assumption. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2222 . This paper was accepted by Jerome Detemple, operations management.
History of Spline Functions and Application in Wood Industry Part 2
Authors: POLGÁR Rudolf , PÁSZTORY Zoltán 
Published: November 2015

<p class="p1">Ez a tanulmány a spline függvények feltalálásával, történetével, fajtáival és alkalmazásukkal kapcsolatos sorozat második része. A spline-okat elsődlegesen mérnöki feladatok és problémák megoldására fejlesztették ki. A spline módszerek könnyű kezelhetősége viszont megnyitotta az utat specifikus spline módszerek kifejlesztésére. Az első részben áttekintettük a spline függvények történetét és fajtáit, e cikkben pedig a spline alkalmazásokra fókuszálunk. Több példán keresztül igyekszünk bemutatni a spline-ok ipari, különös tekintetben a fa- és bútoripari alkalmazásokat. </p>
Faanyag rostirányú tömörítésével kapcsolatos elméleti és gyakorlati kérdések áttekintése III. rész: A tömörített fa mechanikai tulajdonságai, felhasználási lehetőségei
Authors: BÁDER Mátyás 
Published: November 2015

<p class="p1">A cikksorozat áttekintést ad a természetes faanyag hosszirányú tömörítéséről, melynek célja annak hajlékonyabbá, alakíthatóvá tétele. A jelen rész bemutatja a fizikai-mechanikai tulajdonságokat, a modifikált faanyag feldolgozását és a felhasználási lehetőségeket. </p><p class="p1">20% mértékű rostirányú tömörítés esetén a rugalmassági modulus a harmadára csökken a normál faanyaghoz képest. Bükk és tölgy esetén körülbelül 4 GPa lesz, míg a hárompontos hajlító vizsgálat során elviselt behajlás többszörösére növekszik. A hajlítási viszonyszám akár 1/4 fölötti értékű lehet. Bár a nedvesen hajlítható tömörített faanyagnál a hajlítószilárdság akár felére redukálódik, a törésig elnyelt energia többszörösére emelkedik. A ridegsége csökken, a dinamikus törési munkaigény, a fajlagos ütőmunka és az ütő-hajlító szilárdság másfél-kétszeresére javul. A rostirányú tömörítés hatására a fa sűrűsége növekszik, a rezgéscsillapítás keresztirányban nem változik, míg longitudinális irányban többszörösére emelkedik. A húzószilárdság, nyomószilárdság, nyírószilárdság, keménység, csavarállóság csökken. A felsorolt értékek legtöbb esetben a tömörítés mértékével arányosan változnak saját tartományaikban, míg a nedvesség hatására bekövetkező méretváltozás az eredeti anyagéval megegyező marad.</p><p class="p2">A longitudinálisan tömörített fa szárított állapotban az alacsony rugalmasságának köszönhetően megtartja a beállított alakját. A fakárosítókkal szemben a normál faanyaghoz hasonlóan viselkedik. Hajlításához a hagyományos eszközök felhasználhatóak, nagy előnye, hogy hidegen is alakítható állapotban tartható, ezért készletezhető. Elsősorban a belsőépítészet és a bútoripar területén felhasznált anyag, kültérben kevésbé. A termék és tulajdonságai ismertebbé válásával az igények további növekedése várható.</p>
The Axes of Symmetry. Morphology in Aristotle’s Biology
Authors: Carbone Andrea L. 
Published: November 2015

AbstractMy aim in this paper is to outline and discuss the role played in Aristotle’s inquiry into living things by his extensive comparative account of the body plan of different kinds of animals, and of the shapes and figures of their bodily parts, which we may call his morphology. In tackling this question, I begin with Aristotle’s statement that the diagrammatical representation of the body’s organization based on the axes of symmetry is the second most important principle of the inquiry on living things, after the teleology principle. I discuss, in turn, his concern about the applicability of the mathematical approach to the living shapes; his analysis of the ways in which form is related to limit; and his criticism of Democritus’ and Empedocles’ treatment of form and shape. Through exploring the ways in which Aristotle recurs to the morphology principle in the practice of biology, I point out that morphology provides a key methodological framework for the two most important tasks of the research program of the inquiry on living things – the definition of the kinds and the explanation of the causes.
Die Sammlung, Bewahrung und Verwaltung von Netzpublikationen durch Pflichtexemplarbibliotheken in Deutschland
Authors: Steinhauer Eric W. 
Published: November 2015

Zusammenfassung:
Die rechtlichen und organisatorischen Rahmenbedingungen des Sammelns von Netzpublikationen in Deutschland werden dargestellt, die Schaffung ausreichender rechtlicher Rahmenbedingungen angemahnt und eine dreigliedrige Sammlungsstruktur vorgeschlagen. Angeregt wird die Gründung einer eigenständigen Gedächtnisinstitution für das Internet.
Die Strategie 2015–2020 der ZBW – Leibniz Informationszentrum Wirtschaft
Authors: Tochtermann Klaus , Meyer Thorsten 
Published: November 2015

Zusammenfassung:
Anfang 2015 hat die ZBW ihre Strategie 2015–2020 verabschiedet. Nach einer kurzen Darstellung der Ausgangslage, stellt dieser Beitrag den Prozess der Strategieentwicklung sowie die dabei gemachten Erfahrungen vor. Anschließend werden die wichtigsten Prioritäten der Strategie beschrieben, bevor im letzten Abschnitt auf die Umsetzung der Strategie eingegangen wird. Der Prozess der Strategieentwicklung in der ZBW zeichnete sich dadurch aus, dass er gänzlich ohne externe Begleitung stattgefunden hat und zudem durch eine ausgewogene Steuerungsbalance zwischen Bottom-up und Top-down gekennzeichnet war.
New record of Hypnea flexicaulis in New Zealand and description of Calliblepharis psammophilus sp. nov.
Authors: D’Archino Roberta , Nelson Wendy , Yang Mi Yeon , Kim Myung Sook 
Published: November 2015

Abstract
The genus Hypnea has been known in New Zealand for a long time but identification to species level has been difficult as only fragmentary and sterile material has been available for study and thus the genus has remained poorly known. Recently large amounts of Hypnea were collected in northern New Zealand enabling DNA sequencing and the presence of two species was confirmed: Hypnea flexicaulis which represents a new record for New Zealand, and Hypnea cornuta which was previously known from fragmentary material. Both of these species are regarded as introduced in other regions of the world. The new species described in this paper as Calliblepharis psammophilus was identified in the field as a species of Hypnea but morphological observations and molecular data confirmed it does not belong to this genus. It is characterized by caespitose thalli with irregularly branched terete axes and with tapering or curved tips, the axial cell enclosed by 5–7 pericentral cells, cortical cells packed tightly and not forming “rosettes” in surface view. The gonimoblast filaments originate from a fusion cell and develop outwardly in chains. This species is currently known from a single location in the North Island (south eastern coast), New Zealand.
Impairments Computation for Routing Purposes in a Transparent-Access Optical Network Based on Optical CDMA and WDM
Authors: Musa Ahmed 
Published: November 2015

AbstractOptical access networks are becoming more widespread and the use of multiple services might require a transparent optical network (TON). Multiplexing and privacy could benefit from the combination of wavelength division multiplexing (WDM) and optical coding (OC) and wavelength conversion in optical switches. The routing process needs to be cognizant of different resource types and characteristics such as fiber types, fiber linear impairments such as attenuation, dispersion, etc. as well as fiber nonlinear impairments such as four-wave mixing, cross-phase modulation, etc. Other types of impairments, generated by optical nodes or photonic switches, also affect the signal quality (Q) or the optical signal to noise ratio (OSNR), which is related to the bit error rate (BER). Therefore, both link and switch impairments must be addressed and somehow incorporated into the routing algorithm. However, it is not practical to fully integrate all photonic-specific attributes in the routing process. In this study, new routing parameters and constraints are defined that reflect the distinct characteristics of photonic networking. These constraints are applied to the design phase of TON and expressed as a cost or metric form that will be used in the network routing algorithm.
Surface complexation modeling of U(VI) sorption on TiO2 in the presence of fulvic acid
Authors: Ye Yuanlv , Qiao Yahua , Wang Liang , Liu Fudong , Guo Zhijun , Wu Wangsuo , Zhang Chunming 
Published: November 2015

Abstract
In this work, experiments and modeling for the interactions between
uranyl ion and TiO2 in the presence of fulvic acid are
presented. The results demonstrated that FA is strongly bound to
TiO2, and these molecules have a very large effect on the
U(VI) sorption, and vice versa. The results also demonstrated
that U(VI) sorption to TiO2 in the presence and
absence of sorbed FA can be well predicted with the SCD model
(surface and complex distribution). According to the model
calculations, the nature of the interactions between FA with
U(VI) at TiO2 surface is mainly surface complex and
electrostatic potential.
Demonstration of a crown ether process for partitioning strontium from high level liquid waste (HLLW)
Authors: Wang Jianchen , Jing Shan , Chen Jing 
Published: November 2015

Abstract
Chinese HLLW with a higher-salt liquid that was generated via plutonium uranium recovery by extraction (PUREX) processing was
temporarily stored in stainless steel tanks and is waiting for treatment. The volume and heat-loading of the glass block are reduced if
the strontium, cesium, actinides and other long-life radioactive elements, such as Tc in the HLLW, are partitioned before the HLLW
verification. This process is beneficial to preserve the capacity of the geological disposal repository and to minimize long-term
hazards. The process of partitioning strontium from Chinese HLLW using Dicyclohexano-18Crown-6(DCH18C-6) was developed in past decades,
including such fundamental studies as the small scale cold and hot test. In this work, new studies are introduced, including the cold
and the long time hot cascade tests, using a miniature centrifugal contactor set and the pilot-scale cold test using pulse extraction
columns. The results indicate that the crown process is promising for partitioning strontium from Chinese HLLW.
l-Valinate hydrates of nickel, copper and zinc – a structural study
Authors: Kämpfe Alexander , Lindner Fanny , Kroke Edwin , Wagler Jörg 
Published: November 2015

Abstract
The l-valinates M(Val)2 of M = Ni (1), M = Cu (2) and M = Zn (3) are easily obtained as crystalline hydrates. Their structural reinvestigation resulted in a general enhancement of precision for 1 · 2 H2O and 2 · H2O, in case of the copper complex in the correction of the previously reported space group and in case of the zinc complex 3 in the determination of the structure of a new hydrate 3 · 2 H2O.
Genetics on the Fly: A Primer on theDrosophilaModel System
Authors: Hales Karen G , Korey Christopher A , Larracuente Amanda M , Roberts David M 
Published: November 2015

AbstractFruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, evolutionary and population genetics, and other fields. With more tissue types and observable behaviors than in other short-generation model organisms, and with vast genome data available for many species within the genus, the fly’s tractable complexity will continue to enable exciting opportunities to explore mechanisms of complex developmental programs, behaviors, and broader evolutionary questions. This primer describes the organism’s natural history, the features of sequenced genomes within the genus, the wide range of available genetic tools and online resources, the types of biological questions Drosophila can help address, and historical milestones.
Processing of Al–12Si–TNM composites by selective laser melting and evaluation of compressive and wear properties
Authors: Prashanth Konda G. , Scudino Sergio , Chaubey Anil K. , Löber Lukas , Wang Pei , Attar Hooyar , Schimansky Frank P. , Pyczak Florian , Eckert Jürgen 
Published: November 2015

Abstract
Editorial
Authors: Costa Lucia De Fátima Lúcio Gomes da 
Published: November 2015

Caro leitor,

É como muita satisfação que aprensentamos o primeiro volume da EmpíricaBR – Revista Brasileira de Gestão, Negócios e Tecnologia da informação com pesquisas em formato de artigo.
As investigações aqui apresentadas tem o enfoque aplicado na area de de negócios envolvendo perspetivas voltadas para area de tecnologia da informação, por meio de abordagens de estudo de casos sobre o modelo de negócio de Startups.
A area ambiental também é matéria de estudos aplicados por meio de abordagem qualitativa, envolvendo a agenda ambiental e qualitativas, por meio de medida de desempenho organizacional. Logística de exportação e gestão do conhecimento também são abordados por estudos dessa edição. Esperamos que tenha uma boa experiência de pesquisa com os textos especialmente selecionados para esse volume.

Boa leitura.

Lúcia Lúcio
Transformación de Colciencias en departamento administrativo
Authors: Salguero Cubides Jorge 
Published: November 2015

El Gobierno Nacional desarrolla la Ley 1286 del 23 de Enero de 2009, para mejorar el sistema científico y tecnológico: con esta Ley COLCIENCIAS se transforma en el Departamento Administrativo de Ciencia, Tecnología e Innovación, entidad para liderar la producción científica, tecnológica e innovación en Colombia.
Diseño de un modelo de control de mantenimiento aeronáutico con base en la norma NTCGP 1000:24, para realizar auditorías de gestión en la FAC
Authors: Méndez Perdomo William Alexander , Bolívar Parsons Miguel Andrés 
Published: November 2015

Esta investigación pretende formular una alternativa acorde con las orientaciones de la Fuerza Aérea Colombiana para cumplir con el plan institucional 2006-2019 a través de la Norma Técnica Colombiana en la Gestión Pública NTC GPl 000: 2004. Asimismo, se tornaron como referencia formatos comercia les que permit ieron a las diferentes entidades públicas y privadas realizar una constante revisión de los procesos internos y externos cuya finalidad consiste en buscar un mejoramiento continuo, teniendo en cuenta las normas de calidad internacional que buscan establecer una estandarización en beneficio de los usuarios.
Diseño de un manual de seguridad para el almacenamiento de municiones y explosivos en el Comando Aéreo de Combate No.1 de la Fuerza Aérea Colombiana
Authors: Adames Pachón Byron , Polanco Soler Johan 
Published: November 2015

Se consultó al grupo de expertos en explosivos de las Naciones Unidas, los estándares de la USAF y las reglamentaciones de la Fuerza Aérea Colombiana. Se analizó toda la reglamentación y con base en los resultados se estructuró el Manual de Seguridad para el Almacenamiento de Municiones y Explosivos, donde se presentan los parámetros de las normas de seguridad para manipular y almacenar el material bélico con base en las regulaciones internacionales con relación al manejo de los explosivos y municiones
Aplicación de la norma ISO 9001 en la selección y formación de instructores académicos y de vuelo para la escuela de helicópteros de las Fuerzas Militares
Authors: Gómez Isaza Camilo , López Quintero Luis Fernando 
Published: November 2015

En la presente investigación se realizó un análisis de las principales causas de accidentalidad aérea, especialmente en las misiones de instrucción y entrenamiento, tomando como factor principal de éstas al "piloto instructor".