bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diseño de un Basurero Inteligente para Disminuir la Contaminación Causada por Desechos Sólidos en la Unidad Educativa “Juan de Salinas”
Authors: Alarcón Yánez Luis Edwin 
Published: July 2024

El presente trabajo de investigación tiene como finalidad facilitar al o los responsables el manejo de desechos sólidos generados en la Unidad Educativa Juan de Salinas de una manera ágil, rápida y oportuna, para que la población en general realicen sus actividades académicas de manera segura y agradable, el proyecto propone la ejecución de un basurero creado con sistema operativo Android y programación Arduino acompañado a estos dos ejes fundamentales se suman otros componentes como servo motor, sensores, circuitos que permite la construcción y futura ejecución de esta propuesta, se trabajara en el auto estima en todos los miembros de la comunidad educativa es un sentido de responsabilidad, por ello se formuló el objetivo general: determinar la relación entre la teoría conectivista y el aprendizaje de programación Arduino, el dominio científico se atribuye a la innovación socio-educativa, orientado a la línea de investigación Tics en educación, el diseño de la investigación fue no experimental de tipo descriptiva y de campo, su nivel estuvo enmarcado en los ámbitos exploratorio y correlacional.
Analisis Pengaruh Iklim Kerja dan Beban Kerja Mental terhadap Kepuasan Kerja dan Komitmen kepada Organisasi
Authors: Utomo Anggoro Prasetyo , Tehupeiory Karinka Priskila 
Published: July 2024

Tujuan penelitian ini adalah untuk membuat sebuah model yang akan merefleksikan hubungan antara iklim kerja, beban kerja mental, kepuasan kerja, dan komitmen kepada organisasi dari lulusan ITHB yang bekerja sebagai karyawan kontrak di Accenture Sdn. Bhd. Perusahaanmerekrut karyawan-karyawan kontrak untuk mengisi posisi konsultan di perusahaannya. Iklim kerja dan beban kerja mental diduga mempengaruhi kepuasan kerja dan komitmen kepada organisasi dari para lulusan ITHB yang bekerja sebagai karyawan kontrak. Penelitian ini menggunakan metode analisis data SEM (Structural Equation Modeling) dan software WarpPLS 2.0 digunakan untuk menguji hipotesis menyangkut hubungan antarvariabel laten dalam penelitian ini. Hasil penelitian menunjukkan bahwa iklim kerja berpengaruh secara positif dan signifikan terhadap kepuasan kerja. Kepuasan kerja berpengaruh secara positif dan signifikan terhadap komitmen kepada organisasi.This research aims to develop a model which reflects the relationship of work climate, mental workload, job satisfaction, and organizational commitment. The sampled population is ITHB graduates who work for Accenture Sdn. Bhd. The company recruits contract workers to fill in consultant position. Work climate and mental workload are suspected to influence job satisfaction and organizational commitment. This research uses structural equation modeling to analyze the relationship and test the hypothesis. The result shows positive and significant relationship between work climate and organizational commitment. Job satisfaction also shown to have positive and significant relationsihp with organizational commitment.
PENGARUH WORD OF MOUTH, SALES PROMOTION, DAN RELATIONSHIP MARKETING TERHADAP KEPUTUSAN PEMBELIAN DI DUNKIN DONUTS CABANG RUMAH SAKIT UNAIR SURABAYA
Authors: Wulandari Occa Putri Ade , Pratiwi Ni Made Ida , Nasution Ute Chairuz M. 
Published: July 2024

Di Indonesia beragam Industri bergerak di bidang makanan dan minuman mampu berkembang sangat cepat dan pesat dibuktikan dengan munculnya berbagai restoran fast food merek waralaba Internasional seperti (Dunkin Donut’s, KFC,MCD dll). Dalam Industri yang bergerak bidang makanan dan minuman mampu menjadi pendorong utama perekonomian negara Indonesia, terjadi petumbuhan pada industri makanan dan minuman sebesar 2,54% dimulai dari tahun 2020 hingga 2021, dengan nilai uang sebesar Rp 775,1 triliun. Menjadi pemegang sektor ekonomi terpenting di Indonesia, berbagai industri makanan dan minuman selalu berkontribusi terhadap Produk Dosmetik Bruto (PDB). Tujuan dari dilakukan penelitian ini adalah untuk mengetahui apakah pengetahuan Word Of Mouth, Sales Promotion dan Relationship Marketing Dunkin Donut’s cabang rumah sakit Unair Surabaya mempengaruhi terhadap keputusan pembelian. Metode Penelitian ini menggunakan metode kuantitatif. Partisipan/Responden terdiri dari 100 Konsumen Dunkin Donut’s. Dalam pengambilan sampel dilakukan secara Nonprobability Sampling. Hasil pada penelitian ini menunjukan bahwa Word of Mouth,Sales Promotion dan Relationship Marketing berpengaruh secara parsial dan simultan terhadap keputusan pembelian. Pengujian pada uji Simultan F menunjukan dengan F hitung > lebih besar dari F dan Tingkat signifikan lebih kecil dari < 0,05. Menunjukan bahwa pengetahuan Word of Mouth,Sales Promotion dan Relationship Marketing secara bersamaan memiliki pengaruh terhadap Keputusan Pembelian.
Psikoedukasi Manajemen Waktu untuk Mencapai Work Life Balance PT. Makassar Megaputra Prima
Authors: Nurdin Muh. Nur Hidayat , Layuk Evelyn Vinolia , Nurfadilah Andi , Djalal Novita Maulidya , Faradillah Wilda 
Published: July 2024

Karyawan sebagai sumber daya manusia seringkali dituntut menjadi seseorang yang profesional, kompetitif, dan kompeten. Semua tanggung jawab tersebut membuat karyawan kesulitan dan gagal dalam time management sehingga berdampak pada work life balancenya. Maka dari itu, dilaksanakan webinar psikoedukasi pada karyawan PT. Makassar Megaputra Prima dengan tujuan memberikan pemahaman dan meningkatkan pengetahuan para karyawan PT. Makassar Megaputra Prima terkait bagaimana memanajemen waktu secara efektif untuk meningkatkan work life balance pada karyawan. Sebagian karyawan yakni 18 orang berpartisipasi dalam kegiatan webinar ini dan dievaluasi melalui pengukuran pre-test dan post-test. Berdasarkan hasil analisis data, pada uji normalitas ditemukan nilai p 0.00 atau sig.<0.05 yang menunjukan data berdistribusi normal dan pada uji Wilcoxon nilai 0.000 < 0.05 yang menandakan terdapat perbedaan yang signifikan antara hasil pre-test dan post-test. Sehingga disimpulkan kegiatan webinar psikoedukasi ini berhasil memberikan pemahaman dan peningkatan pengetahuan kepada karyawan PT. Makassar Megaputra Prima.
APPLICATION OF USER CENTERED DESIGN (UCD) METHOD FOR DEVELOPING USER INTERFACE AND USER EXPERIENCE IN THE KAIA-PAY APPLICATION
Authors: Beben Sutara Beben Sutara , Nurul Wulan  , An-Nisa Aina Nurwaida  
Published: July 2024

CV Kaia Project is one of the business entities engaged in PPOB which provides digital products such as credit purchases, data packages, PLN Tokens, game vouchers and others. The role of the PPOB system at CV Kaia Project is supported by the KAIA-PAY Application. Based on the results of interviews, namely with the owner of CV Kaia Project, currently the KAIA-PAY Application is already in the implementation stage, but there are several obstacles in its implementation including no forgotten password feature, OTP codes cannot be sent via SMS, etc. while distributing questionnaires on the initial design, namely the results of the initial design evaluation, namely a total of 5 aspects that are worth bad, namely attractiveness, clarity, efficiency, accuracy, stimulus while 1 aspect of novelty is below average. So this research aims to improve User Interface design in accordance with the needs and convenience of KAIA-PAY Application users by applying the UCD Method. The application of the UCD method and evaluation using the User Experience Questionnaire (UEQ) shows that the evaluation results after improvement, namely for the clarity aspect, get a good score, and for the aspects of attractiveness, efficiency, accuracy, stimulation, and novelty get excellent scores.
Extreme Thermophiles
Authors: Grogan Dennis W 
Published: November 2013

Abstract

Extreme thermophiles are microorganisms adapted to temperatures normally found only in hot springs, hydrothermal vents and similar sites of geothermal activity. These unicellular organisms include diverse archaea and bacteria, and they span a wide range of metabolic strategies. Various molecular features enable the cells of extreme thermophiles to function optimally at temperatures that kill other cells. These features include low‐molecular weight compounds that stabilise the conformations of proteins and nucleic acids, enzymes with intrinsically stable folding of the polypeptide and unusual lipids that form highly impermeable membranes. The intrinsically stable enzymes of extreme thermophiles offer advantages for industrial and diagnostic processes ranging from ore processing to molecular genotyping.

Key Concepts:

Bacteria and archaea consist of very simple (prokaryotic) cells but vary greatly with respect to metabolic capabilities, physiological limits and other fundamental properties.

Diverse bacteria and archaea require the temperatures found in geothermal environments for optimal growth, and are classified as extreme thermophiles.

Geothermal activity typically provides chemical energy and nutrients that microorganisms can utilise.

Extreme thermophiles use two basic strategies to avoid thermal denaturation of their enzymes: extrinsic stabilisation, conferred by certain small molecules, and intrinsic stabilisation, conferred by the specific structure and conformation of the enzyme itself.

Intrinsically thermostable enzymes of extreme thermophiles allow certain chemical reactions to be catalysed with high specificity at high temperatures or under other harsh conditions.
Bacterial Cell Differentiation
Authors: Chater Keith F 
Published: November 2013

Abstract

Four bacterial developmental systems are described. In the dimorphic cell cycle of

Caulobacter crescentus

, differences in the proteins assembled at cell poles cause cell division to generate a stalked cell rich in regulator DivK‐P, and competent for continued proliferation, and a swarmer cell rich in regulator CtrA‐P, and unable to proliferate until it discards its flagellum and grows a stalk. The other three systems all lead to the formation of spores, but by completely different routes. In

Bacillus subtilis

, an endospore forms inside a mother cell; in the mycelial

Streptomyces coelicolor

, long hyphae grow into the air and then turn into chains of spores; whereas in

Myxococcus xanthus

, which hunts in motile swarms to prey on other bacteria, the swarm aggregates into a mound to form a fruiting body, inside which cells change into spores. The regulatory cascades leading to differentiation evolved completely independently in the four systems, but show some common strategies.

Key Concepts

Bacterial cells can be both organisationally and developmentally complex.

Bacterial development is usually driven forward by positively acting regulatory cascades, often reinforced by positive feedback loops.

Cascades activating bacterial differentiation often respond to environmental or physiological information through the action of repressors or other negatively acting mechanisms.

Diverse extracellular signals are often employed to allow communication between cells, leading to coordination of bacterial development.

Sporulation has evolved completely independently in different groups of bacteria.

Some kinds of protein recur frequently in bacterial developmental systems, including sigma factors, phosphoproteins and proteases.
Cetacea (Whales, Porpoises and Dolphins)
Authors: Fordyce R Ewan 
Published: November 2013

Abstract

Cetaceans (whales and dolphins) are streamlined aquatic mammals that spend all their lives in water. They are all carnivorous, taking either many small prey by bulk filter‐feeding (Mysticeti, baleen whales), or larger prey by echolocation‐assisted hunting (Odontoceti, dolphins and toothed whales). The main living groups, Mysticeti and Odontoceti, arose from archaic whales – Archaeoceti – some 35 Mya. Cetaceans have been distinct for more than 50 My. Their closest relatives are the hoofed mammals, artiodactyls, such as hippos and cows. Cetaceans include the largest living animals, and range through all oceans and into some rivers. Their active aquatic lifestyle makes them difficult to study. Developments in electronic data‐gathering, tissue analyses, genetic sequencing and phylogenetic analyses, and discoveries of new fossils, have hugely expanded recent understanding. Most of the diversity of living cetaceans (currently 87 species) is concentrated in the oceanic dolphins – Delphinidae (36 species), Ziphiidae (beaked whales, 21 species) and Balaenopteridae (rorquals, 8 species).

Key Concepts:

Cetaceans form a monophyletic group of marine mammals, with three divisions: the living mysticetes (filter‐feeders), odontocetes (echolocators) and the extinct archaeocetes.

Currently, 87 species are recognised: 14 mysticetes (baleen whales) and 73 odontocetes (dolphins, porpoises and toothed whales).

Cetaceans are difficult to study because of their habits, size and rarity, so that, in terms of conservation status, many species are data‐deficient and of uncertain population trend.

As a group, cetaceans range through all oceans, and into some estuaries and rivers; individual species tend to be regionally or hemispherically restricted.

Molecular (genetic) studies of phylogeny will continue to change concepts of relationships, leading to revised classifications at species and genus level.

The earliest known fossil cetaceans lived more than 50 Mya, in what is now India and Pakistan.

Cetaceans are related closely to hoofed mammals (artiodactyls), particularly the hippopotamus.
Plant Endoplasmic Reticulum
Authors: Sparkes Imogen A 
Published: November 2013

Abstract

The plant endoplasmic reticulum (ER) is responsible for the synthesis and often storage of a large group of proteins and lipids that enter the secretory pathway. This multifunctional organelle, which also represents one of the calcium storage compartments in plant cells, has currently received considerable attention from the research community because of features unique to plants that make it particularly interesting for biotechnology. Here, the principles behind ER dynamics in plants, and the molecular factors that control the rapid remodelling and network configuration of the organelle are discussed. Correlations between ER morphology and function indicate the potential to enhance protein storage by merely increasing the capacity of the organelle through altering its shape.

Key Concepts:

The endoplasmic reticulum in plants rapidly changes ‘shape’.

The ER is composed of a polygonal network of tubules and cisternae that readily interconvert.

The ER membrane shaping proteins, reticulons, affect ER curvature whereas root hair defective 3 (RHD3) may affect tubule fusion.

ER network movement is driven by actin and myosin in plants.

The ER is physically connected to Golgi bodies in plant cells.
Identifying Regions of the Human Genome that Exhibit Evidence of Positive Selection
Authors: Kimura Ryosuke , Ohashi Jun 
Published: November 2013

AbstractThe recent availability of genomic data from humans has driven genome‐wide scans for natural selection; these scans use several approaches based on comparative genetics and population genetics. Such studies have identified many possible occurrences of positive selection in the human genome, but the results should be interpreted with caution because false positives are unavoidable. Here, we review approaches for identifying positive selection in the human genome, and explain in detail an approach designed to detect recent positive selection; this approach is based on haplotype variation and linkage disequilibrium. Signatures of positive selection in the human genome offer clues on how biological features of humans have evolved and on how humans have genetically adapted to their environments and own lifestyles – including climate, diet and pathogens.Key Concepts:Comparative genetics approaches identify human‐specific constraint or accelerated gene evolution, but have a methodological limitation.Population genetics approaches based on haplotype variation effectively detect recent positive selection.Genome‐wide scans for selection have identified a number of candidate loci; these findings enable us to reconstruct the history of human genetic adaptation.The results of scans for selection have to be interpreted with caution since the occurrence of false positives and false negatives is inevitable.Further improvements in statistical analysis and establishment of functional analysis are required for future studies to validate variants associated with adaptive phenotypes.
Non‐Classical
MHC
Class I Molecules (
MHC
‐Ib)
Authors: Allen Rachel L , Hogan L 
Published: November 2013

Abstract

Major histocompatibility complex class I (MHC‐I) molecules are a family of structurally related proteins that were first characterised through their central role in adaptive immunity. Classical MHC class I (MHC‐Ia) molecules comprise a heavy chain complexed with β
2
m to display short peptide fragments on the surface of all nucleated cells. As antigen‐presenting proteins, the classical role of MHC‐Ia is to present these peptides for recognition by T‐cell receptors expressed by cytotoxic T‐cells. MHC‐Ia are also recognised by innate immune receptors on other leukocyte subsets. A diverse group of structurally related proteins, collectively termed nonclassical MHC class I molecules or MHC‐Ib, exists to perform a range of alternative immune roles. Here, the authors describe the biology of human MHC‐Ib molecules and their recognition as antigen‐presenting and antigen‐independent ligands for various immune receptors.

Key Concepts:

Classical MHC class I (MHC‐Ia) are highly polymorphic proteins which, together with β
2
m, form a structure that presents short peptide antigens for recognition by the classical αβ T‐cell receptor (TCR) on CD8+ T‐cells.

MHC‐Ia proteins also exist in nonclassical forms – MHC‐I heavy chain structures lacking β
2
m are found on the surface of activated immune cells, where they are recognised by alternative immune receptors such as members of the leukocyte Ig‐like (LILR) family.

Nonclassical MHC‐Ib are usually nonpolymorphic and tend to show a more restricted pattern of expression than their MHC‐Ia counterparts.

MHC‐Ib may be recognised by specific subsets of T‐cell receptors or by innate immune receptors.

Owing to their recognition by a more restricted set of receptors, MHC‐Ib are able to elicit a rapid response from immune cells and are, therefore, regarded as part of the innate immune system.

Some MHC‐Ib act as antigen presenting structures, whereas others are recognised as direct ligands for immune receptors.
Genetics of Panic Disorder
Authors: Maron Eduard , Shlik Jakov 
Published: November 2013

Abstract

The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. To date, several hundreds of candidate genes have been examined in association studies, but most of the results have been negative, inconsistent or awaiting replication. Perhaps most intriguing have been findings involving the genes of biological systems known to be pertinent to anxiety phenotypes, such as serotonin, cholecystokinin and adenosine. An array of other genes related to hormonal, neurotrophic and intracellular systems has also been implicated in disposition to PD. The recent advances in bioinformatics and genotyping technologies, including genome‐wide association and gene expression methods, promise more comprehensive discovery in PD. Preliminary findings point to a number of novel gene targets with still unknown pathogenetic relationship to PD. The progress in clinical and neurobiological concepts of PD may further guide genetic research through the current ambiguity to more definitive findings.

Key Concepts:

The linkage and candidate gene association studies have so far showed only weak success to identify reliable and replicated evidence for the genetic substrate of PD.

The genetic research in PD to date has been mostly restricted to small phenotypically and ethnically diverse datasets with genotyping of limited numbers of SNPs.

An improved understanding of neurobiological pathways of PD could contribute to a more effective identification of candidate genes.

Novel conceptual and analytic approaches, such as pathways‐based analyses, may help to advance GWA studies in PD.

Laboratory panic challenge models may provide clues to genetic predisposition to PD.

The understanding of genetic underpinnings of PD will not be of full value without a conceptual integration of the clinical phenomena of PD with psychological models and neurobiological or molecular substrates underlying its development and course.

The course of PD may depend on the balance between pathogenetic and compensatory or recovery processes, accompanied by activation or inhibition of relevant genes.

PD might exist in many distinct genetic forms, each with a different set of genes, but also in one form with certain genes reflecting broader vulnerability to panicogenesis.

The heterogeneity in PD phenotypes, age of onset, subtypes and severity of panic attacks, gender and familial aggregation were not sufficiently accounted for in most of published studies and should be more carefully addressed in further analyses.

Other comprehensive genetic approaches, including GWA, the analysis of copy number variants and the study of regulatory small noncoding RNAs, may lead to uncovering new genomic mechanisms of PD.
Expectations and Outcomes of Genetics Services
Authors: McAllister Marion 
Published: November 2013

AbstractMeasuring outcomes from clinical genetics services is difficult because the interventions offered focus on provision of information, counselling and genetic testing, and are unlikely to improve patient health status. Furthermore, patients are not always clear what to expect from a clinical genetics service. Patient reported outcome measures (PROMs) have recently gained prominence in healthcare evaluation worldwide. Although PROMs have often been used in research, the PROMs approach to service evaluation is new to clinical genetics, which have historically been evaluated using process measures, for example, number of genetic tests done, waiting times and number of patients attending. A range of PROMs is available for evaluating clinical genetics services, but few suitable PROMs have been robustly validated. Furthermore, PROMs use in this context is likely to be influenced by patients' changing expectations as they navigate their journey through clinical genetics services.Key Concepts:Measuring outcomes from clinical genetics services is difficult and there is no consensus about the best way to do this.Patient expectations may influence satisfaction with healthcare in general and responses to interventions provided in clinical genetics in particular.Health services are increasingly expected to demonstrate that they are delivering patient benefits.To this end, patient reported outcome measures (PROMs) are of growing importance in healthcare evaluation.Although PROMs have their limitations, they can be a useful supplement to traditional quality measures used in healthcare.It is timely for the clinical genetics community to work together in order to develop a standardised core set of quality outcome measures to evaluate services and interventions in research and clinical practice.