bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial single-institutional experience with salvage surgery for stage IV non-small cell lung cancer
Authors: Hishida Tomoyuki , Oka Naoyuki , Yano Kaito , Omura Seiji , Okubo Yu , Masai Kyohei , Kaseda Kaoru , Ohgino Keiko , Terai Hideki , Yasuda Hiroyuki , Asakura Keisuke 
Published: February 2025

Abstract
The purpose of this study was to assess surgical outcomes of salvage surgery for clinical stage IV non-small cell lung cancer. A total of 14 patients who underwent lung resection following systemic therapy between 2010 and 2022 were included in this study. Systemic therapy prior to surgery included agents including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in 8 patients and non-TKI agents in 6 (chemotherapy alone: 4, chemotherapy plus immune checkpoint inhibitors [ICIs]: 2). During a median follow-up of 5.2 years, the EGFR-TKI group showed a favourable 5-year overall survival of 83%; however, it was due to treatment after relapse, and there were no 4-year relapse-free survivors. The non-EGFR-TKI group showed a 5-year relapse-free survival of 33%, and 2 patients have survived more than 3 years without any relapse and further treatment. When considering the role of surgery in multimodal treatment for initial c-stage IV NSCLC, salvage surgery following non-TKI therapy (chemotherapy with or without ICI) can be regarded as genuine salvage surgery.
Development and characterization of millet-based synbiotic paneer containing Lactiplantibacillus plantarum microencapsulated using millet protein isolate and pectin
Authors: Sandhya S N , Karthika T , Swetha V , Jeevitha G C 
Published: February 2025

Abstract
The growing awareness of plant-based alternative protein is coupled with the demand for nutritious and functional foods. The present study explores the development of a novel synbiotic millet-based paneer to meet the needs of lactose-intolerant individuals and the growing demand for innovative functional food products. Protein isolates were extracted from foxtail and proso millet with a yield of 89 ± 0.53 and 90 ± 0.48%, respectively. The Fourier transform infrared spectroscopy spectra of protein isolates showed characteristic peaks of secondary structures (amide I and II) with β-sheets as the predominant secondary structure. The protein and pectin (prebiotics) were used to microencapsulate Lactiplantibacillus plantarum by freeze-drying. It has resulted in high encapsulation efficiency (91.78 ± 2.01–93.5 ± 3.02%) and excellent cell viability (91.79 ± 0.3–92.82 ± 0.2%). The microencapsulated probiotics were used to develop synbiotic millet-based paneer. Foxtail and proso millet-based paneer demonstrated high moisture (76.99 ± 0.08 and 79.62 ± 0.21%) and protein (13.24 ± 0.04 and 11.72 ± 0.03%) with low-fat content (1.9 ± 0.10 and 1.19 ± 0.09%), respectively, indicating better texture and yield of product. Microencapsulated L. plantarum in millet-based paneer, maintained higher viability (6.5 ± 0.2 log CFU/g) than non-encapsulated cells (4.3 ± 0.1 log CFU/g) after 8 days of storage (6 ± 2 °C). These findings highlight the potential of millet proteins for protein enrichment, effective microencapsulation, and the development of novel and nutritious probiotic-rich foods.
Hydrophobic 2-methacryloyloxyethyl phosphorylcholine polymer inhibits peri-implantitis-causing bacterial adhesion on titanium materials
Authors: Akizuki Minato , Murakami Keiji , Sekine Kazumitsu , Murakami Akikazu , Kobayashi Koh , Matsuda Masaru , Matsumoto Haruka , Harata Eiji , Hamada Kenichi , Enggardipta Raras Ajeng , Fujii Hideki , Yumoto Hiromichi 
Published: February 2025

Abstract

Aims
To prevent peri-implantitis, we investigated the adhesion of periodontopathogenic bacteria to titanium surfaces using a hydrophobic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer to inhibit adhesion.

Method and results
We immersed titanium plates (TiPs) coated with a hydrophobic MPC polymer in a bacterial suspension for 30 min or 24 h and measured the number of adherent bacteria. Bacteria adhering to the TiPs were observed using scanning electron microscopy (SEM). Furthermore, mimicking an oral cavity, TiPs coated with MPC polymer and saliva, were immersed in bacterial suspensions of Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans for 24 h, and adenosine triphosphate in the adherent bacteria was measured.
Bacterial adhesion was significantly inhibited on MPC polymer-coated TiPs after 30 min and 24 h. SEM results showed a similar trend. Bacterial adhesion was significantly inhibited on MPC polymer-treated TiPs in the presence of saliva, both before and after MPC treatment. Furthermore, their effectiveness was maintained when the MPC polymer-treated TiPs were stored in saline for 1 week.

Conclusions
Hydrophobic MPC polymer coating on TiP surface inhibited bacterial adhesion, indicating that it may be effective in preventing peri-implantitis.
Effects of high-fiber, high-fruit and high-vegetable, low-fat dietary intervention on the rectal tissue microbiome
Authors: Byrd Doratha A , Gomez Maria , Hogue Stephanie , Wan Yunhu , Ortega-Villa Ana , Warner Andrew , Dagnall Casey , Jones Kristine , Hicks Belynda , Albert Paul , Murphy Gwen , Sinha Rashmi , Vogtmann Emily 
Published: February 2025

Abstract

Background
Emerging evidence suggests that bacteria residing in colorectal tissue are plausibly associated with colorectal cancer (CRC). Prior studies investigated the effects of dietary interventions on the fecal microbiome, but few assessed colorectal tissue microbiome endpoints. We investigated the effects of a high-fiber, high-fruit and -vegetable, low-fat dietary intervention on the rectal tissue microbiome in the Polyp Prevention Trial (PPT).

Methods
PPT is a 4-year randomized clinical trial with intervention goals of consuming: 1) ≥ 18 g of fiber per 1,000 kcal/day; 2) ≥3.5 servings of fruits and vegetables per 1,000 kcal/day; and 3) &lt;20% of kcal/day from fat. Using 16S rRNA gene sequencing, we characterized bacteria in rectal biopsies collected at baseline and the end of years 1 and 4 (N = 233 in intervention arm and N = 222 in control arm). We estimated effects of the intervention on alpha/beta diversity and relative abundance of a priori-selected bacteria using repeated-measures linear mixed-effects models.

Results
The intervention did not statistically significantly modify rectal tissue alpha diversity. Compared to the control arm, relative abundance of a priori-selected Porphyromonas (absolute intervention effects [standard errors] at T1 vs T0=–0.24 [0.07] and T4 vs T0=–0.12 [0.07]; P = .004) and Prevotella (absolute intervention effects at T1 vs T0=–0.40 [0.14] and at T4 vs T0=–0.32 [0.15]; P = .01) were more strongly decreased in the intervention arm.

Conclusion
The PPT intervention did not influence rectal tissue microbiome diversity nor the relative abundance of most bacteria, except for two oral-originating bacteria that were previously associated with CRC presence.

Original Clinical Trial Registry Number
NCT00339625
Solitary fibrous tumor in the pineal region: A series of 5 cases and literature review
Authors: Robins Shannon M , Rosenblatt Mary , Bruce Jeffrey N , Canoll Peter , Zanazzi George 
Published: February 2025

Abstract
Solitary fibrous tumors (SFTs) are fibroblastic mesenchymal neoplasms defined by the presence of a NAB2::STAT6 fusion and exhibit a broad range of behaviors. SFTs in the pineal region are poorly understood due to the limited number of reported cases. Here, we report a 48-year-old woman with a pineal region SFT who subsequently developed metastatic left para-falcine parieto-occipital and right lung upper lobe SFTs over the next 12 years. This was the only pineal SFT identified in an institutional cohort of 34 resected pineal region lesions. Review of another, much larger institutional cohort of pineal region lesions revealed 4 additional patients with SFT but none with extracranial metastasis. We present descriptions of their clinical presentations, treatments, histopathologic findings, available genomic alterations, and longitudinal outcomes. Finally, we performed a comprehensive literature search and identified 19 individual patients with pineal region SFTs. None of these reported neoplasms had an extracranial metastasis. Taken together, this work contributes to the growing body of data characterizing this rare tumor with aggressive potential and reinforces SFTs as a possible differential diagnosis for pineal region tumors.
Petersen’s space hernia as a complication of gastric bypass surgery: a case report
Authors: Palacios Mauricio Fabian , Guachilema Ribadeneira Alex Paul , Yepez Julio , Cisneros Andrea Lisintuña , Imbacuan Sandra Morocho , Verboonen Sergio 
Published: February 2025

Abstract
Internal hernia is the most common complication of Roux-en-Y gastric bypass. Although its incidence rate is low, hernias are becoming more common in patients undergoing bariatric surgery, with Petersen’s hernia being one of the most frequent. The symptoms of internal hernia are variable, and the sensitivity of imaging methods is limited, resulting in a high rate of misdiagnosis of internal hernia by computed tomography. Surgery continues to be the first treatment option in patients presenting with clinical symptoms of obstruction after undergoing Roux-en-Y gastric bypass. Here, we present a case of intestinal obstruction secondary to Petersen’s hernia after Roux-en-Y gastric bypass in the context of bariatric surgery.
X-ray spectral and timing properties of the black hole binary XTE J1859+226 and their relation to jets
Authors: Yamaoka Kazutaka , Kawaguchi Toshihiro , McCollough Michael L , Farinelli Ruben , Trushkin Sergei 
Published: February 2025

Abstract
We compiled the X-ray and soft gamma-ray observations of the Galactic black hole binary XTE J1859$+$226 in the 1999–2000 outburst from RXTE, ASCA, BeppoSAX and CGRO. Throughout systematic spectral analysis using a two-component model consisting of a multi-temperature accretion disk plus a fraction of its flux convolved with an empirical Comptonized powerlaw component, we found that the innermost radius ($r_{\rm in}$) and temperature ($T_{\rm in}$) of the disk are very variable with time in the rising phase of soft X-ray flux where Type-A/-B/C low-frequency quasi-periodic oscillations (QPOs) were found. After this phase, $r_{\rm in}$ remains constant at around $60$ km assuming a distance of $8$ kpc and an inclination angle of $67^{\circ }$, and $T_{\rm in}$ smoothly decays with time. The constant $r_{\rm in}$ suggests a presence of the innermost stable circular orbit (ISCO), with $r_{\rm in}$ repeatedly moving closer and farther away from the ISCO in the rising phase. Both disk parameters are remarkably correlated with independently analyzed timing properties such as QPO frequency and rms variability. Type-A/-B QPOs are seen only when $r_{\rm in}$ is close to the ISCO, while Type-C are seen when $r_{\rm in}$ is truncated and the frequency changes with a relation of $r^{-1.0}_{\rm in}$, supporting that Type-C QPOs occur at the inner edge of the truncated disk. Accurate determinations of the frequency–$r_{\rm in}$ relation for various objects should be a powerful tool to discriminate plausible Type-C QPO models. Furthermore, we suggest that jet ejection events may occur when $r_{\rm in}$ rapidly approaches to the ISCO, along with rapid changes of the disk flux, the rms variability, and the hardness ratio. A rapid shrinkage of $r_{\rm in}$ down to the ISCO can be a useful index as a precursor of radio flares for triggering target-of-opportunity observations and would provide constraints on jet launching mechanisms.
Application of Algorithm-Based Treatment Approach to Low Back Pain in the Emergency Department
Authors: Strickland Kyle J , Kim Howard S , Seitz Amee L 
Published: February 2025

Abstract
Low back pain accounts for nearly 4 million annual emergency department (ED) visits, and patient outcomes following an ED visit for low back pain are poor. Additionally, only a small portion of patients visiting the ED for low back pain follow-up with outpatient physical therapy within 3 months, despite established benefits of early versus delayed physical therapy referral such as improved patient outcomes, less opioid use, and reduced downstream health care utilization. Integrating a physical therapist directly into the ED care team can facilitate evidence-based guideline concordant care and improve patient outcomes, however, physical therapists who are staffed into this role from other settings may lack experience with evaluating and managing patients with acute low back pain. Additionally, there are several unique considerations of the ED care environment which may make existing treatment-based classification approaches difficult to apply in this setting, including physical constraints (eg, delivering care in stretchers and hallways), higher symptom severity and psychosocial stressors necessitating an emergency visit, and greater likelihood of alternative medical diagnoses (eg, kidney stone, aortic aneurysm) contributing to symptoms of low back pain. This perspective presents a modified ED treatment-based classification system (ED-TBC) for low back pain with 3 illustrative case examples. The ED-TBC for low back pain can be used to facilitate guideline concordant care, increase physical therapist confidence in evaluating low back pain in the ED, and reduce clinical practice variation.
Shorter reproductive time span and early menopause increase the risk of ACPA-negative inflammatory arthritis in postmenopausal women with clinically suspect arthralgia
Authors: Heutz Judith W , Boeren Anna M P , Claassen Stijn , van Mulligen Elise , de Jong Pascal H P , van der Helm-van Mil Annette H M 
Published: February 2025

Abstract

Objectives
The drop in oestrogen levels during menopause coincides with the peak incidence of rheumatoid arthritis(RA) in women, suggesting a role of oestrogens in its pathophysiology. However, the timing of the effect of oestrogens during RA-development is unknown. Studies in the final phase of RA-development, from clinically suspect arthralgia(CSA) towards clinically apparent arthritis, are lacking. We hypothesized that shorter lifetime oestrogen exposure might be associated with a higher risk of inflammatory arthritis(IA)-development in women with CSA and studied this in two cohorts.

Methods
Consecutively included women from two independent CSA cohorts, including a total of 433 patients, were prospectively studied. Time to inflammatory arthritis(IA) and RA-development was compared for pre- vs postmenopausal women and, in postmenopausal women, for three measures of lifetime duration of oestrogen exposure: number of reproductive years, number of ovulatory years and early menopause. Analyses were stratified for ACPA-status.

Results
Postmenopausal women, compared with premenopausal women, had an increased risk for ACPA-negative IA (HR 2.9, 95%CI 1.05–8.0) but not for ACPA-positive IA (HR 0.8, 95%CI 0.4–1.9). Results were similar for RA-development. Furthermore, early onset of menopause (HR 11.1, 95%CI 2.4–51.1), lower number of reproductive years (HR per 1 year increase 0.88, 95%CI 0.78–0.99), and lower number of ovulatory years (HR per 1 year increase 0.88, 95%CI 0.78–0.99) increased the risk of ACPA-negative IA, but not ACPA-positive IA.

Conclusion
In patients with arthralgia at-risk for RA, lifetime exposure to oestrogens and/or the drop in oestrogen levels after menopause might play a role in the pathophysiology of ACPA-negative RA.
Locally advanced basal cell carcinoma treated with sonidegib: in vivo monitoring with line-field confocal optical coherence tomography
Authors: Cappilli Simone , Mannino Maria , Palmisano Gerardo , Bocchino Enrico , Piccerillo Alfredo , Paradisi Andrea , Di Stefani Alessandro , Peris Ketty 
Published: February 2025

Abstract

Background
Hedgehog pathway inhibitors, including sonidegib and vismodegib, represent the treatment strategy for ‘difficult-to-treat’ basal cell carcinoma (BCC), encompassing, among others, locally advanced (laBCC) and metastatic BCC. Assessment of therapy response is challenging due to the presence of telangiectasia and scar tissue at the area of the BCC lesion. Line-field confocal optical coherence tomography (LC-OCT) is a new noninvasive imaging technique that provides high-resolution visualization of skin structures.

Objectives
To investigate the value of LC-OCT for the assessment of laBCC response to sonidegib therapy.

Methods
We retrospectively included patients with laBCC treated with sonidegib in the period from May 2020 to May 2023. Patients with laBCC underwent LC-OCT at baseline before starting sonidegib, and after sonidegib discontinuation when clinical complete response (CR) was reached. A subset of patients underwent LC-OCT assessment during sonidegib therapy to assess tumour persistence.

Results
Twenty laBCCs in 20 patients [4 women, 16 men; mean (SD) age 76 (18) years] treated with oral sonidegib 200 mg daily were included in the study. Ten patients obtained an apparent clinical CR; LC-OCT imaging confirmed CR in 7/10 patients (70%), while in the remaining patients (3/10, 30%) LC-OCT revealed findings indicative of BCC non-CR. Ten patients were continuing sonidegib treatment: in this group LC-OCT revealed findings suggestive of BCC persistence in all 10 patients (100%).

Conclusions
In this study we provide preliminary results of the beneficial use of LC-OCT in the management of patients with laBCC treated with sonidegib therapy.
A rare case of aggressive pyoderma gangrenosum with Cogan syndrome in a person with skin of colour
Authors: Nadarajah Nageswary , Clark Lucy , Walton Shernaz 
Published: February 2025

Abstract
Cogan syndrome (CS) is a rare autoimmune vasculitis affecting the audiovestibular and ocular systems. Its pathogenesis is unknown. CS was classified into typical and atypical CS in 1980 to aid its diagnosis. Its association with pyoderma gangrenosum (PG) has only been reported three times in the literature. This is also the first case of its occurrence in a person with skin of colour. CS is a diagnosis of exclusion and thus its diagnosis may present many challenges to healthcare professionals. Herein, we describe the case of a 75-year-old South Asian woman who presented acutely to the Stroke Unit following a right lacunar infarction which was treated with aspirin and clopidogrel. An enlarging nonhealing wound was noted at the site of a recent total left hip replacement. Intravenous antibiotics were started, with multiple surgical debridements performed. During admission, two new painful pustular skin lesions erupted on the chest and abdomen that ulcerated within 2 days. Painful ulcerated lesions with bluish undermined edges were also noted at the left hip wound and two pressure areas of the buttocks. A clinical diagnosis of PG was made and treatment was started with high-dose corticosteroids, which did not lead to improvement. The patient’s past medical history included left eye central retinal vein occlusion with recurrent uveitis and bilateral sensorineural deafness. A diagnosis of atypical CS was made. Four pulsed cyclophosphamide infusions and hyperbaric oxygen healed the lesions. This case demonstrates the complex interplay between PG and CS, which requires further research as it can result in significant morbidity.
In vitro and in vivo efficacity of the Active Oligo Skin complex™, a new active ingredient processed from sea water, on multiple parameters of atopic skins
Authors: Lebonvallet Nicolas , Catovic Chloé , Feuilloley Marc , Leschiera Raphael , Reux Alexia , Talagas Matthieu , Cousin Ianis , Misery Laurent , Simon Emilie , Chopin Sylvie , Gardères Johan 
Published: February 2025

Abstract

Background
Different symptoms are associated with atopic skin (AS), including dryness, pruritus and pain, impacting patients’ quality of life. The environment, microbiota, epidermis, immune and nerve cells are all implicated in the pathogenesis of atopic skin. Staphylococcus aureus is the focus of particular attention. Epidermis is implicated at multiple levels: inflammatory process, barrier, control of moisture and water loss. Sensory neurons that participate in cutaneous neurogenic inflammation and pruritus are seen as a potential new target. Specific management strategies, and future therapies for adults and children are needed to help in more refractory cases. As a baseline of management, guidelines recommend a therapy to moisturize the skin and maintain the skin barrier function, such as emollient.

Objectives
The objective of this work is to evaluate a new product in vitro and in vivo in order to validate the potential of its use to people with atopic skin or dry skin.

Methods
A specific mineral composition, Active Oligo Skin complex™, from sea water was developed and included in a balm. The effects of solution and balm containing the complex were evaluated in vitro on bacteria growth and biofilm formation of Staphylococcus aureus and Staphylococcus epidermidis, different skin models, and in vivo on adult and young volunteers.

Results
In vitro, the complex modulated bacterial biofilm formation and growth, decreased the cytokines [interleukin (IL)-1, IL-6, IL-4] and neuropeptides (SP) release, and increased the expression of CL1 and CL4. On volunteers with dry skin, the complex had a moisturizing effect after 1 h of application. Dryness and roughness were also reduced in young subjects with atopic skin. The balm decreased erythema and pruritus after 21 days of topical application on 60 young subjects. On 22 adult subjects the stinging score was decreased after application.

Conclusions
The Active Oligo Skin complex™ appears to display potent antipruritic and anti-inflammatory activities both in vitro and in vivo.
Transcriptomic analysis identifies muscle-specific mitochondrial and vesicular transport genes as methylmercury toxicity targets in a Drosophila model of Congenital Minamata Disease
Authors: Beamish Catherine R , Becker Jennifer , Tam Lok Ming , Love Tanzy , Rand Matthew D 
Published: February 2025

Abstract
Prenatal methylmercury (MeHg) exposure presents a heightened concern in early human development, as has been exemplified in historic cases of Congenital Minimata Disease (CMD). Children that experience CMD characteristically present with various degrees of cognitive and motor symptoms and signs, much like cerebral palsy. MeHg has thus been characterized as a neurotoxicant, where motor deficits are ascribed to central nervous system targets. Skeletal muscle as a post-synaptic MeHg target and contributor to the etiology of CMD has garnered far less attention. Prior studies using Drosophila to model CMD revealed that developmental exposure of MeHg in the larval/pupal stages can elicit graded and latent dose responses affecting adult flight behavior at lower doses (0.4-2.5 ppm in food) and eclosion (emergence from the pupa case) at higher doses (&gt;2.5 ppm in food). The latter phenotype is accompanied by dysmorphogenesis of skeletal muscles. Here, we investigate respective roles for muscle and neural targets in MeHg toxicity. Using RNA-seq analysis, we find that developmental MeHg exposure produces 10-times as many differentially expressed transcripts in indirect flight muscle (IFM) compared to the ventral nerve cord (VNC). Among known MeHg response genes, Nrf2 antioxidant response pathway genes showed muscle-specific MeHg-induced expression changes. Within the muscle transcriptome, the most enriched and significant Gene Ontology terms identified genes required for mitochondrial ribosomal translation at the pupa stage and mitochondrial function (respiratory chain complex I) and vesicle trafficking (ESCRT III) pathways in adults, all showing decreased expression with MeHg exposure. By using an intact, whole-animal developmental model, we identify preferential candidates to evaluate a novel role for muscle-specific mitochondria and intercellular vesicular communication mechanisms as targets in MeHg toxicity and the etiology of CMD.