bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Rhyme Consistency Score be used as a Feature in Stylistics? A Statistical Endeavour with Hindi Poetry
Authors: Singh Niraj , Naaz Komal , Aryan Raj 
Published: July 2024

Stylistics is the study and analysis of linguistic style using the tools of language. It is an investigation of language elements employed in a spoken or written piece under examination. Rhyme is one such element that can help to inspect style in an artistic piece of writing. It is a literary device that adds melody and aesthetics to any poetic composition. Whether intentionally or unintentionally, the authors’ skill in employing this literary trick will reveal something about their personality in their work. The rhyming quality of a poem has been proven to be a feature in studying literary pieces in the state-of-the-art work that analyzes
Doha
composition using rhyme quality. However, the consistency of rhyme quality throughout a writer's work makes more sense when thinking from a stylistic viewpoint. This article focuses on studying and analyzing poetry to identify the similarities and differences across writers’ styles while utilizing the extent of rhyme consistency as the key feature. The research examines the works of five prominent Hindi poets, namely Ramdhari Singh Dinkar, Jayshankar Prasad, Sumitranandan Pant, Mahadevi Verma, and Harivansh Rai Bachchan, while using their poems as its case study. It provides the rhyme consistency score as a novel stylistic function verified using relevant statistical tests. In the process of achieving the preceding, this article contributes a structured dataset,
ARCSet
, and well-posed style conclusions about the five renowned authors of Hindi literature.
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer
Authors: Sandoval Tito A. , Salvagno Camilla , Chae Chang-Suk , Awasthi Deepika , Giovanelli Paolo , Marin Falco Matias , Hwang Sung-Min , Teran-Cabanillas Eli , Suominen Lasse , Yamazaki Takahiro , Kuo Hui-Hsuan , Moyer Jenna E. , Martin M. Laura , Manohar Jyothi , Kim Kihwan , Sierra Maria A. , Ramos Yusibeska , Tan Chen , Emmanuelli Alexander , Song Minkyung , Morales Diana K. , Zamarin Dmitriy , Frey Melissa K. , Cantillo Evelyn , Chapman-Davis Eloise , Holcomb Kevin , Mason Christopher E. , Galluzzi Lorenzo , Ni Zhou Zhen , Vähärautio Anna , Cloonan Suzanne M. , Cubillos-Ruiz Juan R. 
Published: July 2024

Abstract
Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects of iron chelation in the tumor microenvironment are unknown. Here, we report that treatment with deferiprone, an FDA-approved iron chelator, unleashes innate immune responses that restrain ovarian cancer. Deferiprone reprogrammed ovarian cancer cells toward an immunostimulatory state characterized by the production of type-I IFN and overexpression of molecules that activate NK cells. Mechanistically, these effects were driven by innate sensing of mitochondrial DNA in the cytosol and concomitant activation of nuclear DNA damage responses triggered upon iron chelation. Deferiprone synergized with chemotherapy and prolonged the survival of mice with ovarian cancer by bolstering type-I IFN responses that drove NK cell-dependent control of metastatic disease. Hence, iron chelation may represent an alternative immunotherapeutic strategy for malignancies that are refractory to current T-cell–centric modalities.
Significance: This study uncovers that targeting dysregulated iron accumulation in ovarian tumors represents a major therapeutic opportunity. Iron chelation therapy using an FDA-approved agent causes immunogenic stress responses in ovarian cancer cells that delay metastatic disease progression and enhance the effects of first-line chemotherapy.
See related commentary by Bell and Zou, p. 1771
Yttrium-90 Induces an Effector Memory Response with Neoantigen Clonotype Expansion: Implications for Immunotherapy
Authors: Núñez Kelley , Sandow Tyler , Gimenez Juan , Hibino Mina , Cohen Ari , Thevenot Paul 
Published: July 2024

Abstract

Yttrium-90 (90Y) transarterial radioembolization can safely and effectively treat hepatocellular carcinoma (HCC). Clinical trials combining 90Y with immunotherapy are aimed at improving treatment response rates. The impact of transient 90Y-induced lymphopenia on T-cell homeostasis and functional dynamics is unknown. Paired blood specimens were collected prior to first-cycle 90Y and at imaging follow-up in patients with HCC Barcelona Clinic Liver Cancer stages A–B. Flow cytometry and T-cell receptor (TCR) sequencing were used to monitor changes in T-cell subsets and TCR repertoire following 90Y. Objective response (OR) rates were determined using modified RECIST and defined as either OR or nonobjective response. Time-to-progression (TTP) was defined as progression to Barcelona Clinic Liver Cancer stage C within 6 months following 90Y. 90Y induced shifts in both CD4+ (P = 0.049) and CD8+ (P &lt; 0.001) toward an effector memory T-cell response independent of treatment response rate. Nonresponders to 90Y were characterized by a sustained elevation in both naïve CD4+ cells (P = 0.019) and programmed cell death protein 1 expression in CD8+ cells (P = 0.003). Paired analysis of the TCR repertoire revealed a variable induction of neoantigen clonotypes and expansion of existing clonotypes independent of 90Y response. In patients with an OR, changes in TCR clonality did not influence TTP. However, polyclonal profiles in patients without an OR were associated with shorter TTP (P = 0.005; HR, 10.8) and 75% disease progression rates 6 months following treatment. 90Y induces a population shift from central to effector memory accompanied by neoantigen T-cell responses independent of treatment response rate. Monoclonal shifts in the post-90Y T-cell repertoire had superior overall TTP and improved TTP in patients with a first-cycle nonobjective response.

Significance:
90Y can safely treat HCC; however, it causes transient lymphopenia. In this article, 90Y stimulates a peripheral effector memory response independent of initial treatment response. TCR sequencing revealed that polyclonal profiles in patients without an OR to treatment were associated with rapid progression rates 6 months after 90Y.
Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study
Authors: Abd-Elmoniem Khaled Z. , Edwan Jehad H. , Dietsche Katrina B. , Villalobos-Perez Alfredo , Shams Nour , Matta Jatin , Baumgarten Leilah , Qaddumi Waleed N. , Dixon Sydney A. , Chowdhury Aruba , Stagliano Michael , Mabundo Lilian , Wentzel Annemarie , Hadigan Colleen , Gharib Ahmed M. , Chung Stephanie T. 
Published: July 2024

BACKGROUND:
Youth-onset type 2 diabetes (Y-T2D) is associated with increased risk for coronary atherosclerotic disease, but the timing of the earliest pathological features and evidence of cardiac endothelial dysfunction have not been evaluated in this population. Endothelial function magnetic resonance imaging may detect early and direct endothelial dysfunction in the absence of classical risk factors (severe hyperglycemia, hypertension, and hyperlipidemia). Using endothelial function magnetic resonance imaging, we evaluated peripheral and coronary artery structure and endothelial function in young adults with Y-T2D diagnosed ≤5 years compared with age-matched healthy peers. We isolated and characterized plasma-derived small extracellular vesicles and evaluated their effects on inflammatory and signaling biomarkers in healthy human coronary artery endothelial cells to validate the imaging findings.

METHODS:
Right coronary wall thickness, coronary artery flow–mediated dilation, and brachial artery flow–mediated dilation were measured at baseline and during isometric handgrip exercise using a 3.0T magnetic resonance imaging. Human coronary artery endothelial cells were treated with Y-T2D plasma–derived small extracellular vesicles. Protein expression was measured by Western blot analysis, oxidative stress was measured using the redox-sensitive probe dihydroethidium, and nitric oxide levels were measured by 4-amino-5-methylamino-2’,7’-difluororescein diacetate.

RESULTS:

Y-T2D (n=20) had higher hemoglobin A1c and high-sensitivity C-reactive protein, but similar total and LDL (low-density lipoprotein)-cholesterol compared with healthy peers (n=16). Y-T2D had greater coronary wall thickness (1.33±0.13 versus 1.22±0.13 mm;
P
=0.04) and impaired endothelial function: lower coronary artery flow–mediated dilation (−3.1±15.5 versus 15.9±17.3%;
P
<0.01) and brachial artery flow–mediated dilation (6.7±14.7 versus 26.4±15.2%;
P
=0.001). Y-T2D plasma–derived small extracellular vesicles reduced phosphorylated endothelial nitric oxide synthase expression and nitric oxide levels, increased reactive oxygen species production, and elevated ICAM (intercellular adhesion molecule)–mediated inflammatory pathways in human coronary artery endothelial cells.

CONCLUSIONS:
Coronary and brachial endothelial dysfunction was evident in Y-T2D who were within 5 years of diagnosis and did not have severe hyperglycemia or dyslipidemia. Plasma-derived small extracellular vesicles induced markers of endothelial dysfunction, which corroborated accelerated subclinical coronary atherosclerosis as an early feature in Y-T2D.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02830308 and NCT01399385.
Premorbid Blood Pressure Control Modifies Risk of DWI Lesions With Acute Blood Pressure Reduction in Intracerebral Hemorrhage
Authors: Ridha Mohamed , Hannawi Yousef , Murthy Santosh , Carvalho Poyraz Fernanda , Kumar Aditya , Park Soojin , Roh David , Sekar Padmini , Woo Daniel , Burke James 
Published: July 2024

BACKGROUND:
Hypoperfusion due to blood pressure (BP) reduction is a potential mechanism of cerebral ischemia after intracerebral hemorrhage. However, prior evaluations of the relationship between BP reduction and ischemia have been conflicting. Untreated chronic hypertension is common in intracerebral hemorrhage and alters cerebral autoregulation. We hypothesized that the risk of diffusion-weighted imaging (DWI) hyperintensities from acute BP reduction is modified by premorbid BP control.

METHODS:
Individuals enrolled in the ERICH study (Ethnic/Racial Variations of Intracerebral Hemorrhage) from 2010 to 2015 were categorized as untreated, treated, or nonhypertensive based on preintracerebral hemorrhage diagnosis and antihypertensive medication use. The percent reduction of systolic BP (SBP) was calculated between presentation and 24 hours from admission. The primary outcome was the presence of DWI lesions. Using logistic regression, we tested the association between chronic hypertension status, SBP reduction, and their interaction with DWI lesion presence.

RESULTS:

From 3000 participants, 877 with available magnetic resonance imaging met inclusion (mean age, 60.5±13.3 years; 42.5% women). DWI lesions were detected in 25.9%. Untreated, treated, and no hypertension accounted for 32.6%, 47.9%, and 19.5% of cases, respectively. SBP reduction was not directly associated with DWI lesions; however, an interaction effect was observed between SBP reduction and chronic hypertension status (
P
=0.036). Nonhypertensive subjects demonstrated a linear risk of DWI lesion presence with greater SBP reduction, whereas untreated hypertension demonstrated a stable risk across a wide range of SBP reduction (
P
=0.023).

CONCLUSIONS:
Premorbid BP control, especially untreated hypertension, may influence the relationship between DWI lesions and acute BP reduction after intracerebral hemorrhage.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01202864.
Heat Stress Metrics, Trends, and Extremes in the Southeastern United States
Authors: Wodzicki Kyle R. , Ennis Kelsey E. , Knight Desiree A. , Milrad Shawn M. , Dello Kathie D. , Davis Corey , Heuser Sean , Thomas Blaine , Raye Lily 
Published: July 2024

Abstract
Humid heat and associated heat stress have increased in frequency, intensity, and duration across the globe, particularly at lower latitudes. One of the more robust metrics for heat stress impacts on the human body is wet-bulb globe temperature (WBGT), because it incorporates temperature, humidity, wind speed, and solar radiation. WBGT can typically only be measured using nonstandard instrumentation (e.g., black globe thermometers). However, estimation formulas have been developed to calculate WBGT using standard surface meteorological variables. This study evaluates several WBGT estimation formulas for the southeastern United States using North Carolina Environment and Climate Observing Network (ECONet) and U.S. Military measurement campaign data as verification. The estimation algorithm with the smallest mean absolute error was subsequently chosen to evaluate summer WBGT trends and extremes at 39 ASOS stations with long continuous (1950–2023) data records. Trend results showed that summer WBGT has increased throughout much of the southeastern United States, with larger increases at night than during the day. Although there were some surprisingly large WBGT trends at higher elevation locations far from coastlines, the greatest increases were predominantly located in the Florida Peninsula and Louisiana. Increases in the intensity and frequency of extreme (90th percentile) WBGTs were particularly stark in large coastal urban centers (e.g., New Orleans, Tampa, and Miami). Some locations like New Orleans and Tampa have experienced more than two additional extreme heat stress days and nights per decade since 1950, with an exponential escalation in the number of extreme summer nights during the most recent decade.

Significance Statement
Humid heat and associated heat stress pose threats to health in the moist subtropical climate of the southeastern United States. Wet-bulb globe temperature (WBGT) is a robust metric for heat stress but must be estimated using complex algorithms. We first evaluated the accuracy of three WBGT algorithms in the southeastern United States, using measured verification data. Subsequently, we used the most accurate algorithm to investigate WBGT trends and extremes since 1950 in 39 cities. Results showed that summer heat stress has increased throughout the region, especially at night. Increases in the intensity and frequency of extreme heat stress were most prevalent at urban coastal locations in Florida and Louisiana, emphasizing the impacts of increased urbanization and evaporation on heat stress.
Diverse Responses of Strong Positive SST and Rainfall Indian Ocean Dipole Events under Greenhouse Warming
Authors: Wang Jia-Zhen , Geng Tao , Cai Wenju , Wang Guojian , Xie Mingmei , Wu Lixin , Chen Zhaohui 
Published: July 2024

Abstract
Recent research has shown that there is a projected increase in the frequency of strong positive Indian Ocean dipole (spIOD) events in terms of both sea surface temperature (SST) and precipitation. However, it is not clear whether the spIOD events defined by SST and precipitation, hereafter referred to as SST-spIOD and Pr-spIOD events, respectively, will increase at the same pace under greenhouse warming. Using climate models from phase 5 of the Coupled Model Intercomparison Project (CMIP5) and CMIP6 that can reasonably simulate the spIOD events, here we find that the occurrence of Pr-spIOD events increases much more than that of SST-spIOD events (+217% vs +77%) under the future high-emission scenario. The diverse response stems from a notably large increase in the spIOD events with strong rainfall but moderate SST anomalies (Pr-only spIOD), which is facilitated by a change in the local meridional Hadley circulation induced by land–sea thermal contrast in addition to the background mean-state SST warming. For the spIOD events with prominent anomalies in both rainfall and SST (concurrent spIOD), their occurrences are projected to increase, but their average SST amplitude is projected to weaken. The increased occurrence is associated with a westward-extended structural change induced by mean linear zonal advection feedbacks, while the weakened event-average SST amplitude results from a more stabilized atmosphere and coincides with the projected reduction in IOD SST skewness. Our results suggest that IOD-related mitigation strategies should consider the diverse responses of different kinds of spIOD events to greenhouse warming.
A Coupled Quadrupole Mode in the South Pacific
Authors: Chen Yuanrui , Wright Jonathon S. 
Published: July 2024

Abstract
Although links between the atmospheric convergence zone and the local ocean dipole in the South Atlantic are well established, relationships between the South Pacific convergence zone (SPCZ) and the South Pacific quadrupole (SPQ) remain largely unexplored. Based on maximum covariance analysis applied to a 110-yr monthly coupled atmosphere–ocean reanalysis, we describe a coupled quadrupole mode (CQM) that connects the SPCZ and SPQ during austral summer [December–February (DJF)]. The CQM is linked to the “enhanced SPCZ” mode in the atmosphere and the SPQ in the ocean, with the atmospheric signal leading the ocean signal by about 1 month. This coupled mode essentially represents the atmospheric and oceanic responses to a stationary Rossby wave train that propagates from low- to high latitudes before reflecting back toward lower latitudes around 150°E. Coupled atmosphere–ocean feedbacks help to maintain anomalous convective activity in the SPCZ and related circulation anomalies. The stationary waves that organize the CQM are often rooted in anomalous convection over the Maritime Continent and have close connections with the atmospheric wavenumber-4 mode in the midlatitude Southern Hemisphere.

Significance Statement
In this study, we investigate the relationships between coherent large-scale patterns in the South Pacific Ocean and the overlying atmosphere. These patterns, which we refer to as a coupled quadrupole for their four centers of action, impact both local communities and the global climate by shaping rainfall and temperature anomalies across the “four corners” of the South Pacific: east–west and north–south. We show that this coupled quadrupole arises as the joint atmospheric and oceanic response to a large-scale wave that arcs across the entire South Pacific basin more than 10 km above the surface and that feedbacks from the ocean to the atmosphere help it to last longer.
Artificial Intelligence for Psychotherapy: A Review of the Current State and Future Directions
Authors: Beg Mirza Jahanzeb , Verma Mohit , M. Vishvak Chanthar K. M. , Verma Manish Kumar 
Published: July 2024

Background: Psychotherapy is crucial for addressing mental health issues but is often limited by accessibility and quality. Artificial intelligence (AI) offers innovative solutions, such as automated systems for increased availability and personalized treatments to improve psychotherapy. Nonetheless, ethical concerns about AI integration in mental health care remain. Aim: This narrative review explores the literature on AI applications in psychotherapy, focusing on their mechanisms, effectiveness, and ethical implications, particularly for depressive and anxiety disorders. Methods: A review was conducted, spanning studies from January 2009 to December 2023, focusing on empirical evidence of AI’s impact on psychotherapy. Following PRISMA guidelines, the authors independently screened and selected relevant articles. The analysis of 28 studies provided a comprehensive understanding of AI’s role in the field. Results: The results suggest that AI can enhance psychotherapy interventions for people with anxiety and depression, especially chatbots and internet-based cognitive-behavioral therapy. However, to achieve optimal outcomes, the ethical integration of AI necessitates resolving concerns about privacy, trust, and interaction between humans and AI. Conclusion: The study emphasizes the potential of AI-powered cognitive-behavioral therapy and conversational chatbots to address symptoms of anxiety and depression effectively. The article highlights the importance of cautiously integrating AI into mental health services, considering privacy, trust, and the relationship between humans and AI. This integration should prioritize patient well-being and assist mental health professionals while also considering ethical considerations and the prospective benefits of AI.
End of Life Care Practices at a Tertiary Cancer Centre in India: An Observational Study
Authors: Maurya Bhanu P. , Gupta Raghav , Rathore Puneet , Mishra Seema , Bharati Sachidanand J. , Kumar Vinod , Gupta Nishkarsh , Garg Rakesh , Bhatnagar Sushma 
Published: July 2024

Purpose To assess the End of life care (EOLC ) practices and the magnitude of futile care in a tertiary cancer center. To find out the barriers in provision of good EOLC in cancer patients. Methods An observational study was done on 129 patients. Patients were enrolled using the palliative prognostic index (PPI) in the end of life stages. Socio-demographic and clinical details were recorded. Detailed counselling done by the palliative physician or the oncologist was recorded. The barriers in provision of care were recorded. Results In this study initial experience of 129 patients were analyzed. PPI score was >6 (survival shorter than 3 weeks) in 85 (65.89%) ; 34 (26.36%) had PPI score between >4 to 6 (survival between 3 to 6 weeks); and 10 (7.75%) patients had PPI score less than equal to 4( survival more than 6 weeks).77 (59.69%) patients preferred home as their place for EOLC while 41(31.78%) preferred hospital, 7 (5.43%) preferred hospice while 4 (3.10%) opted ICU for their EOLC . The most common barrier associated was caregiver related in 34 case, followed by physician related in 14 cases and patients related in 3 cases, because of hope of being cured in hospital, social stigma, fear of worsening of symptoms at home, denial. Conclusion EOLC is the least studied part of patient care with various barriers. With proper communication and a good palliative care support, futile treatment can be avoided. With healthy communication we can empower family members and patients for a good EOLC.