bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of EHR User Interface Changes on Internal Prescription Discrepancies
Authors: Sawarkar A. , Dementieva Y.A. , Breydo E. , Ramelson H. , Turchin A. 
Published: August 2014

SummaryObjective: To determine whether specific design interventions (changes in the user interface (UI)) of an electronic health record (EHR) medication module are associated with an increase or decrease in the incidence of contradictions between the structured and narrative components of electronic prescriptions (internal prescription discrepancies).Materials and Methods: We performed a retrospective analysis of 960,000 randomly selected electronic prescriptions generated in a single EHR between 01/2004 and 12/2011. Internal prescription discrepancies were identified using a validated natural language processing tool with recall of 76% and precision of 84%. A multivariable autoregressive integrated moving average (ARIMA) model was used to evaluate the effect of five UI changes in the EHR medication module on incidence of internal prescription discrepancies.Results: Over the study period 175,725 (18.4%) prescriptions were found to have internal discrepancies. The highest rate of prescription discrepancies was observed in March 2006 (22.5%) and the lowest in March 2009 (15.0%).Addition of „as directed“ option to the <Frequency> dropdown decreased prescription discrepancies by 195 / month (p = 0.0004). An non-interruptive alert that reminded providers to ensure that structured and narrative components did not contradict each other decreased prescription discrepancies by 145 / month (p = 0.03). Addition of a „Renew / Sign“ button to the Medication module (a negative control) did not have an effect in prescription discrepancies.Conclusions: Several UI changes in the electronic medication module were effective in reducing the incidence of internal prescription discrepancies. Further research is needed to identify interventions that can completely eliminate this type of prescription error and their effects on patient outcomes.Citation: Turchin A, Sawarkar A, Dementieva YA, Breydo E, Ramelson H. Effect of EHR user interface changes on internal prescription discrepancies. Appl Clin Inf 2014; 5: 708–720http://dx.doi.org/10.4338/ACI-2014-03-RA-0023
Electroretinographic Characteristics in Children with Infantile Nystagmus Syndrome and Early-Onset Retinal Dystrophies
Authors: Kurent Alma , Stirn-Kranjc Branka , Brecelj Jelka 
Published: August 2014

Purpose To differentiate early-onset retinal dystrophies on the basis of electroretinogram (ERG) characteristics in children with infantile nystagmus syndrome (INS). Methods Thirty-seven children with INS and early-onset retinal dystrophies were included, with diagnosis according to clinical and ERG findings. Three ERG protocols were used according to the child's age and 17 children were followed with 2 protocols: 27 (mean 2.1 years) were recorded with skin electrodes to flash stimulation, 16 (mean 6.5 years) with skin electrodes to full-field stimulation, and 11 (mean 12.2 years) with HK electrodes to full-field stimulation. The ERGs were compared to those of age-matched controls, with differences significant if p<0.05. Results Clinical and electrophysiologic findings were in agreement across all of the children. In nine children with Leber congenital amaurosis, the scotopic and photopic ERGs were not recordable under all protocols. Six children with congenital stationary night blindness (CSNB) had electronegative scotopic ERG under all protocols, those with complete CSNB had absent rod ERG, and those with incomplete CSNB had reduced rod ERG. Eight children with achromatopsia had nonrecordable photopic and subnormal scotopic ERG under all protocols. The implicit times of the scotopic b-waves were prolonged. One child had blue-cone monochromatism and reduced photopic and normal S-cone ERG. Six children with cone–rod dystrophy without systemic disorder, and seven children with systemic disorder, had affected photopic and scotopic ERGs under all protocols. Conclusions In children with INS, some early-onset retinal dystrophies can be differentiated through ERGs, also with skin electrodes.
Gender Difference Does not Affect the Outcomes of Eccentric Rotational Acetabular Osteotomy Used in Hip Dysplasia
Authors: Amano Takafumi , Hasegawa Yukiharu , Seki Taisuke , Yamaguchi Jin , Iwase Toshiki 
Published: August 2014

Introduction Various types of periacetabular osteotomies have been proposed to treat acetabular dysplasia for young and active patients. Acetabular dysplasia is prevalent in women and rare in men, therefore few reports exist concerning periacetabular osteotomy of male patients. The purpose of this study is to clarify the gender differences in surgical techniques, radiographic and clinical outcomes. Materials and methods Between 1989 and 2007, we performed 530 eccentric rotational acetabular osteotomies and followed them annually for more than five years. Thirty-six male patients were investigated. As a control group, 72 female patients were matched for age and preoperative stage of osteoarthritis at the time of surgery. We evaluated operative time and blood loss, radiographic parameters, Harris Hip Score (HHS) and survival rate. We investigated the clinical and radiographic differences between men and women. Results The mean operative time was 148 min in males and 135 min in females. The bleeding during surgery was 445 g in males and 351 g in females. HHS improved 94.1 points in males and 93.5 points in women postoperatively. The mean CE angle improved 31.7° in males and 35.1° in females. The mean AHI was 90.8% in males and 94.1% in females postoperatively. The survival rate of male patients were 92.8% and that of female patients were 98.1%. Conclusions The mean operative time and the blood loss were not significantly different between male and female patients. Postoperative CE angle tended to be smaller in male than female patients. The survival rate was not significantly different between males and females. Gender difference did not affect the clinical outcomes of ERAO in patients with hip dysplasia.
“We Languish in Obscurity” The Silence of God as Atavistic Calvinism in Cormac McCarthy's Fiction
Authors: Essary Kirk 
Published: August 2014

AbstractGod's silence and hiddenness constitute a recurring theme in the works of American novelist Cormac McCarthy, and while this feature of his fiction can at one level be appreciated by considering McCarthy's fiction alongside late-modern literary giants like Melville and Dostoevsky—who dealt often with similar themes—I argue in this essay that McCarthy's God might be more fully understood when considered as falling on (and furthering) a trajectory inaugurated by sixteenth-century Protestant theologian John Calvin.
Repellent Attractions
Authors: MacKendrick Karmen 
Published: August 2014

Abstract
Beauty appears to be a nice thing, complete with the rather tepid quality that the word nice has come to imply. But beauty is also linked with danger, uncertainly, and powerful passion. The “nice” dimension of beauty is underwhelmingly charismatic: the passionate dimension of beauty suggests charisma. This article looks at its tension between fearfulness and peaceful pleasure through the example of saintly bodies and their tendency both to draw our desire to know them, and thereby ourselves, and to repel us in their grotesque openness. Tapping the critical resources of Kant and Rilke as well as medieval hagiography, the article thinks through beauty as charismatic and uncharismatic.
Is Democratic Charisma Thinkable?
Authors: Bromell Nicholas 
Published: August 2014

Abstract
In this article, I argue that the idea of “democratic charisma” is not the oxymoron it first appears to be but is, rather, a term that helps us think about the affective aspects of democratic citizenship and more broadly about the role aesthetics might play in democratic theory. After defining what I understand “charisma” to be, I begin with two historical examples of democratic charisma in U.S. cultural history: Ralph Waldo Emerson's notion of “the great man” in the 1840s–1850s, and the linked notions of black “power,” “beauty,” and “soul” in the 1960s–1970s. I show that despite their obvious differences, these two examples have structural similarities: most important, both have a qualified conception of “freedom” that takes full account of the circumstances that make absolute freedom impossible. Consequently, both locate the aesthetic not in a realm of pure freedom and play but in a space where freedom and necessity, or autonomy and heteronomy, meet.
Sterling's Call to Charisma: Revealing Weber's Spirit in Contemporary Black Ministry
Authors: Manigault-Bryant James A. 
Published: August 2014

Abstract
In this article, I reflect on a series of interviews I conducted with Rev. Rod Sterling, an African American minister with whom I have been in contact for over a decade, to consider Max Weber's conceptualization of charisma. Instead of relying on Weber's writings that explicitly outline the meaning of charisma, I focus on a passage in Weber's The Protestant Ethic and the Spirit of Capitalism, where he positions Richard Baxter, the seventeenth-century Presbyterian pastor, as a ministerial figure beyond the bounds of modernity's time. Locating Baxter in a different temporality presents for Weber a means of mapping how Baxter's theology becomes secularized into the infamous “Protestant work ethic.” Likewise, Reverend Sterling's experiences of racism in the Presbyterian Church push him out of time and make him a figure of charisma.
Shit White People Say About Beyoncé
Authors: Dubler Joshua 
Published: August 2014

Abstract
The recent Internet meme “Shit X Say,” is a genre that burlesques cultural riffs common to a particular subculture. In this spirit, “Shit White People Say about Beyoncé” identifies key tropes in mainstream middlebrow criticism about the pop superstar as featured in a recent cycle of well-publicized events. These discourses' flagship feature is their declaration of Beyoncé's formal perfection. When scraped at, however, Beyoncé's putative perfection is revealed as the dual vessel for a Nietzschean longing for a sui generis will and a Weberian anxiety about the value of labor for charisma.
EROTIZAÇÃO PRECOCE: UMA ANÁLISE DAS REPRESENTAÇÕES DA INFÂNCIA NAS PÁGINAS DO SUPLEMENTO INFANTIL FOLHINHA
Authors: GUTJAHR Mayara , JOHN Valquíria Michela 
Published: August 2014

Este artigo trata da análise das representações da identidade infantil construída pelo suplemento infantil Folhinha, do jornal Folha de S. Paulo, nas edições publicadas nos meses de janeiro a dezembro de 2010. Esta pesquisa se propôs a verificar de que maneira o respectivo objeto de estudo trabalha com as questões relacionadas à erotização precoce em suas páginas. Como procedimento metodológico para coleta e análise das 51 edições que compuseram o universo desta monografia, foi utilizada a proposta da Análise de Conteúdo (Bardin, 2010), sendo que a categorização e tematização partiram do conceito de Desenvolvimento Humano, seguindo a proposta de categorização de conteúdo adotada pela Agência de Notícias dos Direitos da Infância (ANDI). Como é na infância que a criança apreende boa parte das experiências que poderão ser resgatadas ao longo da vida, percebeu-se que a Folhinha colabora para a preservação da infância ao não induzir os pequenos à erotização precoce; no entanto, poderia ter aberto mais espaço para os assuntos relacionados à sexualidade das crianças, que muitas vezes utilizam a mídia para sanar suas dúvidas.
COMUNICABILIDADE METAFÓRICA: DO SENSÍVEL À DESIGNAÇÃO
Authors: MARTINS FERREIRA Dina Maria 
Published: August 2014

O objetivo desse estudo é tentar demonstrar que o sentido primitivo pode ser entendido como pulsão metafórica da linguagem, que emerge no processo designativo. Segundo Derrida, o ‘sopro’ é linguagem não articulada, aquela que manifesta o sensível do ser humano, que, buscando realizar-se na linguagem articulada, opera o deslocamento de sentido. Esse percurso do sensível pode ser retratado pelo movimento respiratório: na inspiração o sopro se faz sentir, e na expiração emerge a fala cuja força designativa expressa o pertencimento identitário.
A DESESCOLARIZAÇÃO DA SOCIEDADE PARA A CONSTRUÇÃO DO CONHECIMENTO
Authors: PACHIONI Miguel Sgarbi 
Published: August 2014

O presente texto apresenta a resenha do livro "Sociedade sem escolas", do polímata pensador austríaco Ivan Illich. Nesta obra, publicada originalmente em 1971, o modelo de disciplina escolar universal, amplamente adotado no ocidente, é confrontado com a possibilidade de se desescolarizar as instituições e o modelo de aprendizagem para que, assim, tenha-se a possibilidade de compactuar a verdadeira potencialidade criativa dos educandos com suas habilidades. Com isso, fica evidente a razão pelo qual o autor estrutura seu pensamento em direção a natureza da aprendizagem, para quem educar não é escolarizar e não se faz para todos, mas sim por todos.
Expediente
Authors: SILVESTRIN Celsi Brönstrup 
Published: August 2014

Editora-chefe:Profª Drª Celsi Brönstrup SilvestrinEditora adjunta:Profª Drª Regiane Regina Ribeiro Colaborador desta edição:Prof. Dr. João Somma Neto Equipe Editorial:Anderson LopesEduardo Covalesky DiasJoão Paulo da SilvaJuliane JuskiMario LamenhaMarcielly MorescoMarcos MarianoThaís MocelinValdecir Bressani
Biogeochemical control of marine productivity in the Mediterranean Sea during the last 50 years
Authors: Macias Diego , Garcia‐Gorriz Elisa , Piroddi Chiara , Stips Adolf 
Published: August 2014

AbstractThe temporal dynamics of biogeochemical variables derived from a coupled 3‐D model of the Mediterranean Sea are evaluated for the last 50 years (1960–2010) against independent data on fisheries catch per unit effort (CPUE) for the same time period. Concordant patterns are found in the time series of all of the biological variables (from the model and from fisheries statistics), with low values at the beginning of the series, a later increase, with maximum levels reached at the end of the 1990s, and a posterior stabilization. Spectral analysis of the annual biological time series reveals coincident low‐frequency signals in all of them. The first, more energetic signal peaks around the year 2000, while the second, less energetic signal peaks near 1982. Almost identical low‐frequency signals are found in the nutrient loads of the rivers and in the integrated nutrient levels in the surface marine ecosystem. Nitrate concentration shows a maximum level in 1998, with a later stabilization to present‐day values, coincident with the first low‐frequency signal found in the biological series. Phosphate shows maximum concentrations around 1982 and a posterior sharp decline, in concordance with the second low‐frequency signal observed in the biological series. That result seems to indicate that the control of marine productivity (plankton to fish) in the Mediterranean is principally mediated through bottom‐up processes that could be traced back to the characteristics of riverine discharges. The high sensitivity of CPUE time series to environmental conditions might be another indicator of the overexploitation of this marine ecosystem.
Observations of the inner radiation belt: CRAND and trapped solar protons
Authors: Selesnick R. S. , Baker D. N. , Jaynes A. N. , Li X. , Kanekal S. G. , Hudson M. K. , Kress B. T. 
Published: August 2014

AbstractMeasurements of inner radiation belt protons have been made by the Van Allen Probes Relativistic Electron‐Proton Telescopes as a function of kinetic energy (24 to 76 MeV), equatorial pitch angle, and magnetic L shell, during late 2013 and early 2014. A probabilistic data analysis method reduces background from contamination by higher‐energy protons. Resulting proton intensities are compared to predictions of a theoretical radiation belt model. Then trapped protons originating both from cosmic ray albedo neutron decay (CRAND) and from trapping of solar protons are evident in the measured distributions. An observed double‐peaked distribution in L is attributed, based on the model comparison, to a gap in the occurrence of solar proton events during the 2007 to 2011 solar minimum. Equatorial pitch angle distributions show that trapped solar protons are confined near the magnetic equator but that CRAND protons can reach low altitudes. Narrow pitch angle distributions near the outer edge of the inner belt are characteristic of proton trapping limits.
Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation
Authors: Gianatassio Ryan , Kawamura Shuhei , Eprile Cecil L , Foo Klement , Ge Jason , Burns Aaron C. , Collins Michael R. , Baran Phil S. 
Published: August 2014

AbstractA simple method to convert readily available carboxylic acids into sulfinate salts by employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, including a key trifluoromethylcyclopropanation reagent, TFCS‐Na. The reactivity of six of these salts towards CH functionalization was field‐tested using several different classes of heterocycles.
Endoplasmic Reticulum Degradation–Enhancing α‐Mannosidase–like Protein 1 Targets Misfolded HLA–B27 Dimers for Endoplasmic Reticulum–Associated Degradation
Authors: Guiliano David B. , Fussell Helen , Lenart Izabela , Tsao Edward , Nesbeth Darren , Fletcher Adam J. , Campbell Elaine C. , Yousaf Nasim , Williams Sarah , Santos Susana , Cameron Amy , Towers Greg J. , Kellam Paul , Hebert Daniel N. , Gould Keith G. , Powis Simon J. , Antoniou Antony N. 
Published: August 2014

ObjectiveHLA–B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). This study was undertaken to define the role of the UPR‐induced ER‐associated degradation (ERAD) pathway in the disposal of HLA–B27 dimeric conformers.MethodsHeLa cell lines expressing only 2 copies of a carboxy‐terminally Sv5‐tagged HLA–B27 were generated. The ER stress–induced protein ER degradation–enhancing α‐mannosidase–like protein 1 (EDEM1) was overexpressed by transfection, and dimer levels were monitored by immunoblotting. EDEM1, the UPR‐associated transcription factor X‐box binding protein 1 (XBP‐1), the E3 ubiquitin ligase hydroxymethylglutaryl‐coenzyme A reductase degradation 1 (HRD1), and the degradation‐associated proteins derlin 1 and derlin 2 were inhibited using either short hairpin RNA or dominant‐negative mutants. The UPR‐associated ERAD of HLA–B27 was confirmed using ER stress–inducing pharamacologic agents in kinetic and pulse chase assays.ResultsWe demonstrated that UPR‐induced machinery can target HLA–B27 dimers and that dimer formation can be controlled by alterations to expression levels of components of the UPR‐induced ERAD pathway. HLA–B27 dimers and misfolded major histocompatibility complex class I monomeric molecules bound to EDEM1 were detected, and overexpression of EDEM1 led to inhibition of HLA–B27 dimer formation. EDEM1 inhibition resulted in up‐regulation of HLA–B27 dimers, while UPR‐induced ERAD of dimers was prevented in the absence of EDEM1. HLA–B27 dimer formation was also enhanced in the absence of XBP‐1, HRD1, and derlins 1 and 2.ConclusionThe present findings indicate that the UPR ERAD pathway can dispose of HLA–B27 dimers, thus presenting a potential novel therapeutic target for modulation of HLA–B27–associated inflammatory disease.
Regulation of Cytokine Polarization and T Cell Recruitment to Inflamed Paws in Mouse Collagen‐Induced Arthritis by the Chemokine Receptor CXCR6
Authors: Slauenwhite Drew , Gebremeskel Simon , Doucette Carolyn D. , Hoskin David W. , Johnston Brent 
Published: August 2014

ObjectiveThe chemokine receptor CXCR6 is highly expressed on lymphocytes isolated from the synovium of patients with rheumatoid arthritis, psoriatic arthritis, or juvenile idiopathic arthritis, suggesting that CXCR6 regulates immune cell activation or infiltration into arthritic joints. This study was undertaken to examine the role of CXCR6 in T cell activation and arthritis development.MethodsA collagen‐induced arthritis model was used to examine arthritis development in wild‐type and CXCR6−/− mice. CXCR6 expression, lymphocyte accumulation, and intracellular cytokine production were examined by flow cytometry. Collagen‐specific antibodies were measured in the serum. Collagen‐specific recall responses were examined in vitro via proliferation and cytokine release assays. T cell homing to inflamed joints was examined using competitive adoptive transfer of dye‐labeled lymphocytes from wild‐type and CXCR6−/− mice.ResultsThe numbers of CXCR6+ T cells were increased in the paws and draining lymph nodes of arthritic mice. The incidence of arthritis, disease severity, extent of T cell accumulation, and levels of collagen‐specific IgG2a antibodies were significantly reduced in CXCR6−/− mice compared to wild‐type mice. T cells from wild‐type mice exhibited Th1 (interferon‐γ [IFNγ]) polarization in the inguinal lymph nodes following immunization. At disease peak, this shifted to a Th17 (interleukin‐17A [IL‐17A]) response in the popliteal lymph nodes. T cells in CXCR6−/− mice exhibited impaired cytokine polarization, resulting in a decreased frequency and number of IL‐17A– and IFNγ‐producing cells. Recruitment of activated CXCR6−/− mouse T cells to the inflamed paws was impaired compared to recruitment of wild‐type mouse T cells.ConclusionThese experiments demonstrate that CXCR6 plays important roles in the pathogenesis of arthritis through its effects on both T cell cytokine polarization and homing of T cells to inflamed joints.
Glucuronidation of macelignan by human liver microsomes and expressed UGT enzymes: identification of UGT1A1 and 2B7 as the main contributing enzymes
Authors: Liu Hongming , Wu Zhufeng , Ma Zhiguo , Wu Baojian 
Published: August 2014

ABSTRACTMacelignan is a natural phenolic compound that possesses many types of health benefits such as antiinflammation. This study aimed to characterize the metabolism of macelignan via the glucuronidation pathway and to identify the main UGT enzymes involved in macelignan glucuronidation. The rates of glucuronidation were determined by incubating macelignan with UDPGA‐supplemented microsomes. Kinetic parameters were derived by fitting an appropriate model to the data. Reaction phenotyping, the relative activity factor (RAF) approach and activity correlation analysis were employed to identify the main UGT enzymes contributing to the hepatic metabolism of macelignan. Glucuronidation of macelignan in pooled human liver microsomes (pHLM) was rather efficient with a high CLint (the intrinsic clearance) value of 13.90 ml/min/mg. All UGT enzymes, except UGT1A4, 1A6 and 2B10, showed metabolic activities toward macelignan. UGT1A1 and 2B7 were the enzymes with the highest activities; the CLint values were 4.92 and 2.13 ml/min/mg, respectively. Further, macelignan glucuronidation was significantly correlated with 3‐O‐glucuronidation of β‐estradiol (r = 0.69; p < 0.01) and glucuronidation of zidovudine (r = 0.60; p < 0.05) in a bank of individual HLMs (n = 14). Based on the RAF approach, UGT1A1 and 2B7, respectively, contributed 55.40% and 32.20% of macelignan glucuronidation in pHLM. In conclusion, macelignan was efficiently metabolized via the glucuronidation pathway. It was also shown that UGT1A1 and 2B7 were probably the main contributors to the hepatic glucuronidation of macelignan. Copyright © 2014 John Wiley & Sons, Ltd.
Wie die Mücke den Menschen findet
Authors: Brennicke Axel 
Published: August 2014

AbstractViele Spezies von Stechmücken sind auf den Menschen spezialisiert. Sie finden ihre Opfer durch eine Kombination aus erhöhter CO2‐Konzentration, Duftstoffen wie Milch‐ und Buttersäure sowie einem Temperaturgradienten hin zu 37 °C. Neue Untersuchungen zeigen jetzt, dass die veränderte CO2‐Konzentration das Hauptsignal ist, das die Erkennung der beiden anderen Faktoren verstärkt. Mücken, in denen der CO2‐Sensor ausgeschaltet ist, können dennoch ihre Ziele finden, wenn auch etwas schlechter. Für einen wirksamen Schutz müssen also mindestens zwei der Signale blockiert oder verwirrt werden.