bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing and Mimicking Bacterial Features to Combat Cancer: From Living Entities to Artificial Mimicking Systems
Authors: Gao Peng , Duan Zhenyu , Xu Gang , Gong Qiyong , Wang Jing , Luo Kui , Chen Jie 
Published: August 2024

AbstractBacterial‐derived micro‐/nanomedicine has garnered considerable attention in anticancer therapy, owing to the unique natural features of bacteria, including specific targeting ability, immunogenic benefits, physicochemical modifiability, and biotechnological editability. Besides, bacterial components have also been explored as promising drug delivery vehicles. Harnessing these bacterial features, cutting‐edge physicochemical and biotechnologies have been applied to attenuated tumor‐targeting bacteria with unique properties or functions for potent and effective cancer treatment, including strategies of gene‐editing and genetic circuits. Further, the advent of bacteria‐inspired micro‐/nanorobots and mimicking artificial systems has furnished fresh perspectives for formulating strategies for developing highly efficient drug delivery systems. Focusing on the unique natural features and advantages of bacteria, this review delves into advances in bacteria‐derived drug delivery systems for anticancer treatment in recent years, which has experienced a process from living entities to artificial mimicking systems. Meanwhile, a summary of relative clinical trials is provided and primary challenges impeding their clinical application are discussed. Furthermore, future directions are suggested for bacteria‐derived systems to combat cancer.
Ultra‐Weak Polarization‐Strain Coupling Effect Boosts Capacitive Energy Storage
Authors: Zhang Leiyang , Jing Ruiyi , Huang Yunyao , Yang Yule , Li Yang , Tang Mingyang , Cao Shuyao , Chen Zibin , Gao Feng , Du Yuxiao , Zhou Shiyu , Zhao Jianwei , Liu Shiyu , Wang Dawei , Zhang Shujun , Jin Li 
Published: August 2024

AbstractIn pulse power systems, multilayer ceramic capacitors (MLCCs) encounter significant challenges due to the heightened loading electric field (E), which can lead to fatigue damage and ultrasonic concussion caused by electrostrictive strain. To address these issues, an innovative strategy focused on achieving an ultra‐weak polarization‐strain coupling effect is proposed, which effectively reduces strain in MLCCs. Remarkably, an ultra‐low electrostrictive coefficient (Q33) of 0.012 m4 C−2 is achieved in the composition 0.55(Bi0.5Na0.5)TiO3‐0.45Pb(Mg1/3Nb2/3)O3, resulting in a significantly reduced strain of 0.118% at 330 kV cm−1. At the atomic scale, the local structural heterogeneity leads to an expanded and loose lattice structure, providing ample space for large ionic displacement polarization instead of lattice stretching when subjected to the applied E. This unique behavior not only promotes energy storage performance (ESP) but also accounts for the observed ultra‐low Q33 and strain. Consequently, the MLCC device exhibits an impressive energy storage density of 14.6 J cm−3 and an ultrahigh efficiency of 93% at 720 kV cm−1. Furthermore, the superior ESP of the MLCC demonstrates excellent fatigue resistance and temperature stability, making it a promising solution for practical applications. Overall, this pivotal strategy offers a cost‐effective solution for state‐of‐the‐art MLCCs with ultra‐low strain‐vibration in pulse power systems.
Tuning the 5d State of Pr3+ in Oxyhalides for Efficient Deep Ultraviolet Upconversion
Authors: Du Yangyang , Jin Zhengyuan , Li Ziyu , Sun Tianying , Meng Haotian , Jiang Xiaojuan , Wang Yu , Peng Dengfeng , Li Jianwei , Wang Aiwu , Zou Hua , Rao Feng , Wang Feng , Chen Xian 
Published: August 2024

AbstractVisible‐to‐ultraviolet (UV) upconversion provides a fascinating strategy to achieve deep UV emission through readily accessible visible light. However, the intensity of deep UV emission obtained through visible‐to‐UV upconversion progress is still far from satisfactory, severely constraining its practical applications. Herein, a novel class of praseodymium ion (Pr3+)‐doped rare‐earth oxyhalides (YOCl, YOBr, and LuOBr) to achieve efficient upconverted deep UV emission in the spectral range of 250–350 nm is developed. The upconverted UV emission intensity of LuOBr:Pr3+ is determined to be 56.7 times stronger than that of the well‐established Lu7O6F9:Pr3+. When employed as a photon‐converter to activate photocatalytic water splitting reactions, upconverted deep UV emission enables H2 generation under visible light (λ > 420 nm) excitation from a xenon lamp. The efficient deep UV upconversion stems from tuning 4f15d1 state of Pr3+ by oxyhalide constituent which both facilitates the absorption of excitation photons in long‐lived intermediate 4f2 states and suppress the probability of nonradiative relaxation from 4f15d1 state. These findings not only provide new insights into a mechanistic understanding of the host effect on upconversion process but also make a breakthrough in developing efficient deep upconversion materials that will expand their further applications.
Broadband Near‐Infrared Cr4+‐Doped Garnet Phosphors through Divalent Calcium Charge Compensation for Advanced Crystal Fiber Amplifiers
Authors: Hsiao Yu‐Hsuan , Chen Kuan‐Chun , Chien Chun‐Ling , Huang Wen‐Tse , Majewska Natalia , Kamiński Mikołaj , Mahlik Sebastian , Leniec Grzegorz , Mijowska Ewa , Huang Sheng‐Lung , Liu Ru‐Shi 
Published: August 2024

AbstractNear‐infrared‐II (NIR‐II) phosphors are extensively used as NIR phosphor‐converted light‐emitting diodes across various applications. Nonetheless, their application in fiber communication remains underexplored. Furthermore, efficiency challenges persist in developing broadband NIR crystal fiber amplifiers. A series of the Y3−yAl5−xO12:xCr,yCa2+ phosphors with boosted Cr4+ concentration via calcium charge compensation is synthesized, and the optimized sample is fabricated to crystal fibers to reveal the application of the NIR‐II phosphors to fiber communication. The fabricated Cr4+‐doped crystal fiber, exhibiting broadband Cr4+ emission within 1100–1600 nm, effectively covers the high‐transmission loss region caused by water absorption in the telecommunication band. Comprehensive characterization and analyses of the Cr4+ are discussed. Y2.84Al4.9O12:0.1Cr,0.16Ca2+ crystal fiber, fabricated through phosphor synthesis, pellets’ production, and the laser‐heated pedestal growth method, exhibits superior photoluminescence compared to the commercial Cr4+‐doped Y3Al5O12 crystal fiber. Here the potential of NIR‐II phosphors is highlighted in enhancing fiber communication and valuable insights for their future application are provided.
Detection of Foodborne Pathogens Through Volatile Organic Compounds Sensing via Metal Oxide Gas Sensors
Authors: Lawaniya Shiv Dutta , Awasthi Anjali , Menezes Prashanth W. , Awasthi Kamlendra 
Published: August 2024

AbstractFoodborne pathogens are a crucial diagnostic target for the food, beverage, and healthcare sectors due to their ubiquity and the potential damage they may do to the public's well‐being, food safety, and the economy. Over the past few decades, there has been an increased focus on developing highly precise and trusted biosensors in an effort to eliminate the discrepancy between reporting demands and currently used traditional detection approaches. Metal oxide semiconductor (MOS)‐based gas sensors have rapidly advanced in recent years, becoming a dominating technology for developing devices in food‐quality management, biomedical research, and diagnostics. This review systematically explores recent advancements in gas sensing technologies utilizing metal oxide‐based sensors for the detection of foodborne pathogens through the analysis of volatile organic compounds (VOCs). The comprehensive discussion encompasses insights into various foodborne pathogens, their implications for human health, diverse metal oxide characteristics, strategies for enhancing their sensing capabilities, and the distinctive features of VOCs. Furthermore, a thorough examination of the utilization of different metal oxides in VOC sensing is provided, addressing both existing challenges and potential future developments. In summary, employing gas sensing techniques for foodborne pathogen detection holds substantial commercial promise compared to alternative bio‐sensing approaches.
Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development
Authors: Wang Wenwen , Wang Yanyan , Su Libo , Zhang Mengtian , Zhang Tianyu , Zhao Jinyue , Ma Hongyan , Zhang Dongming , Ji Fen , Jiao Ryan Dingli , Li Hong , Xu Yuming , Chen Lei , Jiao Jianwei 
Published: August 2024

AbstractOligodendrocyte precursor cells (OPCs) migrate extensively using blood vessels as physical scaffolds in the developing central nervous system. Although the association of OPCs with the vasculature is critical for migration, the regulatory mechanisms important for OPCs proliferative and oligodendrocyte development are unknown. Here, a correlation is demonstrated between the developing vasculature and OPCs response during brain development. Deletion of endothelial stimulator of interferon genes (STING) disrupts angiogenesis by inhibiting farnesyl‐diphosphate farnesyltransferase 1 (FDFT1) and thereby reducing cholesterol synthesis. Furthermore, the perturbation of metabolic homeostasis in endothelial cells increases interleukin 17D production which mediates the signal transduction from endothelial cells to OPCs, which inhibits oligodendrocyte development and myelination and causes behavioral abnormalities in adult mice. Overall, these findings indicate how the endothelial STING maintains metabolic homeostasis and contributes to oligodendrocyte precursor cells response in the developing neocortex.
Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors
Authors: Qiu Junjun , Ren Tingting , Liu Qinqin , Jiang Qian , Wu Tong , Cheng Leong Chi , Yan Wenqing , Qu Xinyu , Han Xiao , Hua Keqin 
Published: August 2024

AbstractHigh‐grade serous tubo‐ovarian cancer (HGSTOC) is an aggressive gynecological malignancy including homologous recombination deficient (HRD) and homologous recombination proficient (HRP) groups. Despite the therapeutic potential of poly (ADP‐ribose) polymerase inhibitors (PARPis) and anti‐PDCD1 antibodies, acquired resistance in HRD and suboptimal response in HRP patients necessitate more precise treatment. Herein, single‐cell RNA and single‐cell T‐cell receptor sequencing on 5 HRD and 3 HRP tumors are performed to decipher the heterogeneous tumor immune microenvironment (TIME), along with multiplex immunohistochemistry staining and animal experiments for validation. HRD tumors are enriched with immunogenic epithelial cells, FGFR1+PDGFRβ+ myCAFs, M1 macrophages, tumor reactive CD8+/CD4+ Tregs, whereas HRP tumors are enriched with HDAC1‐expressing epithelial cells, indolent CAFs, M2 macrophages, and bystander CD4+/CD8+ T cells. Significantly, customized therapies are proposed. For HRD patients, targeting FGFR1+PDGFRβ+ myCAFs via tyrosine kinase inhibitors, targeting Tregs via anti‐CCR8 antibodies/TNFRSF4 stimulation, and targeting CXCL13+ exhausted T cells by blocking PDCD1/CTLA‐4/LAG‐3/TIGIT are proposed. For HRP patients, targeting indolent CAFs, targeting M2 macrophages via CSF‐1/CSF‐1R inhibitors, targeting bystander T cells via tumor vaccines, and targeting epithelial cells via HDAC inhibitors. The study provides comprehensive insights into HRD and HRP TIME and tailored therapeutic approaches, addressing the challenges of PARPi‐resistant HRD and refractory HRP tumors.
CDK4/6 Inhibitors Impede Chemoresistance and Inhibit Tumor Growth of Small Cell Lung Cancer
Authors: Wen Yang , Sun Xue , Zeng Lingge , Liang Shumei , Li Deyu , Chen Xiangtian , Zeng Fanrui , Zhang Chao , Wang Qiongyao , Zhong Qinsong , Deng Ling , Guo Linlang 
Published: August 2024

AbstractSmall cell lung cancer (SCLC) is characterized by rapid development of chemoresistance and poor outcomes. Cyclin‐dependent kinase 4/6 inhibitors (CDK4/6is) are widely used in breast cancer and other cancer types. However, the molecular mechanisms of CDK4/6 in SCLC chemoresistance remain poorly understood. Here, Rb1flox/flox, Trp53flox/flox, Ptenflox/flox (RTP) and Rb1flox/flox, Trp53flox/flox, MycLSL/LSL (RPM) spontaneous SCLC mouse models, SCLC cell line‐derived xenograft (CDX) models, and SCLC patient‐derived xenograft (PDX) models are established to reveal the potential effects of CDK4/6is on SCLC chemoresistance. In this study, it is found that CDK4/6is palbociclib (PD) or ribociclib (LEE) combined with chemotherapeutic drugs significantly inhibit SCLC tumor growth. Mechanistically, CDK4/6is do not function through the classic Retionblastoma1 (RB) dependent axis in SCLC. CDK4/6is induce impair autophagy through the AMBRA1‐lysosome signaling pathway. The upregulated AMBRA1 protein expression leads to CDK6 degradation via autophagy, and the following TFEB and TFE3 nuclear translocation inhibition leading to the lysosome‐related genes levels downregulation. Moreover, it is found that the expression of CDK6 is higher in SCLC tumors than in normal tissue and it is associated with the survival and prognosis of SCLC patients. Finally, these findings demonstrate that combining CDK4/6is with chemotherapy treatment may serve as a potential therapeutic option for SCLC patients.
Neighboring Effect‐Initiated Supramolecular Nanocomplex with Sequential Infiltration as Irreversible Apoptosis Inducer for Synergetic Chemo‐Immunotherapy
Authors: Ye Mengjie , Hu Junfeng , Han Linlin , Zhang Hengbo , Xue Peng , Kang Yuejun , Bai Shuang , Xu Zhigang 
Published: August 2024

AbstractChemotherapy‐based combination regimens are recommended as first‐line treatment for colorectal cancer. However, multidrug resistance (MDR) and limited drug infiltration in tumor microenvironment remain critical challenges. Herein, a pH/redox dual activated supramolecular DAS@CD‐OxPt (IV) nanoparticles (NPs) via host‐guest molecular recognition to achieve relay drugs delivery of active oxaliplatin (OxPt (IV)) and Src inhibitor dasatinib (DAS) between tumor cells is developed. DAS@CD‐OxPt (IV) NPs exhibit prolonged circulation in the blood and intra‐tumoral retention. Triggered by the endo/lysosome (pH 5.0), flexible DAS@CD‐OxPt (IV) NPs exhibited proton‐driven in situ assembly to form nanofiber in tumor cells. Dual chemotherapeutic agents released from DAS@CD‐OxPt (IV) NPs synergistically cause irreversible DNA damage by blocking p53‐mediated DNA repair. Supramolecular nanofibers can further serve as the “ammunition depot” to continuously release drugs from dying cells and transport them into neighboring tumor cells, leading to domino‐like cell death and enhanced immunogenicity. Furthermore, DAS@CD‐OxPt (IV) NPs combined with immune checkpoint blockade (ICB) therapy strikingly suppress CT26 tumor growth and pulmonary metastasis.
Surface Acoustic Wave‐Enhanced Multi‐View Acoustofluidic Rotation Cytometry (MARC) for Pre‐Cytopathological Screening
Authors: Zhang Xiaoyan , Dumčius Povilas , Mikhaylov Roman , Qi Jiangfa , Stringer Mercedes , Sun Chao , Nguyen Van Dien , Zhou You , Sun Xianfang , Liang Dongfang , Liu Dongge , Yan Bing , Feng Xi , Mei Changjun , Xu Cong , Feng Mingqian , Fu Yongqing , Clayton Aled , Zhi Ruicong , Tian Liangfei , Dong Zhiqiang , Yang Xin 
Published: August 2024

AbstractCytopathology, crucial in disease diagnosis, commonly uses microscopic slides to scrutinize cellular abnormalities. However, processing high volumes of samples often results in numerous negative diagnoses, consuming significant time and resources in healthcare. To address this challenge, a surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) technique is developed for pre‐cytopathological screening. MARC enhances cellular morphology analysis through comprehensive and multi‐angle observations and amplifies subtle cell differences, particularly in the nuclear‐to‐cytoplasmic ratio, across various cell types and between cancerous and normal tissue cells. By prioritizing MARC‐screened positive cases, this approach can potentially streamline traditional cytopathology, reducing the workload and resources spent on negative diagnoses. This significant advancement enhances overall diagnostic efficiency, offering a transformative vision for cytopathological screening.
The Multi‐Functional Third Acceptor Realizes the Synergistic Improvement in Photovoltaic Parameters and the High‐Ratio Tolerance of Ternary Organic Photovoltaics
Authors: Liu Yuhao , Zhan Lingling , Li Zhongjie , Jiang Hang , Qiu Huayu , Sun Xiaokang , Hu Hanlin , Sun Rui , Min Jie , Yu Jinyang , Fu Weifei , Yin Shouchun , Chen Hongzheng 
Published: August 2024

AbstractThe ternary strategy proves effective for breakthroughs in organic photovoltaics (OPVs). Elevating three photovoltaic parameters synergistically, especially the proportion‐insensitive third component, is crucial for efficient ternary devices. This work introduces a molecular design strategy by comprehensively analyzing asymmetric end groups, side‐chain engineering, and halogenation to explore the outstanding optoelectronic properties of the proportion‐insensitive third component in efficient ternary systems. Three asymmetric non‐fullerene acceptors (BTP‐SA1, BTP‐SA2, and BTP‐SA3) are synthesized based on the Y6 framework and incorporated as the third component into the D18:Y6 binary system. BTP‐SA3, featuring asymmetric terminal (difluoro‐indone and dichloride‐cyanoindone terminal), with branched alkyl side chains, exhibited high open‐circuit voltage (VOC), balanced crystallinity and compatibility, achieving synergistic enhancements in VOC (0.862 V), short circuit‐current density (JSC, 27.52 mA cm−2), fill fact (FF, 81.01%), and power convert efficiency (PCE, 19.19%). Device based on D18/Y6:BTP‐SA3 (layer‐by‐layer processed) reached a high efficiency of 19.36%, demonstrating a high tolerance for BTP‐SA3 (10–50%). This work provides novel insights into optimizing OPVs performances in multi‐component systems and designing components with enhanced tolerance.
Decolorization of Lignin for High‐Resolution 3D Printing of High Lignin‐Content Composites
Authors: Böcherer David , Montazeri Ramin , Li Yuanyuan , Tisato Silvio , Hambitzer Leonhard , Helmer Dorothea 
Published: August 2024

AbstractLignin, one of the most abundant biomaterials and a large‐scale industrial waste product, is a promising filler for polymers as it reduces the amount of fossil resources and is readily available. 3D printing is well‐known for producing detailed polymer structures in small sizes at low waste production. Especially light‐assisted 3D printing is a powerful technique for production of high‐resolution structures. However, lignin acts as a very efficient absorber for UV and visible light limiting the printability of lignin composites, reducing its potential as a high‐volume filler. In this work, the decolorization of lignin is presented for high‐resolution 3D printing of biocomposites with lignin content up to 40 wt.%. Organosolv lignin (OSL) is decolorized by an optimized low‐energy process of acetylation and subsequent UV irradiation reducing the UV absorbance by 71%. By integration of decolorized lignin into bio‐based tetrahydrofurfuryl acrylate (THFA), a lignin content of 40 wt.% and a resolution of 250 µm is achieved. Due to the reinforcing properties of lignin, the stiffness and strength of the material is increased by factors of 15 and 2.3, respectively. This work paves the way for the re‐use of a large amount of lignin waste for 3D printing of tough materials at high resolution.
Monoclinic Silver Vanadate (Ag0.33V2O5) as a High‐Capacity Stable Cathode Material for Aqueous Manganese Batteries
Authors: Lee Hyeonjun , Lee Hyungjin , Pyun Jangwook , Hong Seung‐Tae , Chae Munseok S. 
Published: August 2024

AbstractAqueous rechargeable metal batteries have recently garnered considerable attention owing to their low cost, sufficient capacity, and the use of non‐flammable water‐based electrolytes. Among them, manganese batteries are particularly favored because of their stability, abundance, affordability, and high energy density. Despite their advantages, Mn storage host structures remain underexplored. Therefore, developing innovative host materials is crucial for advancing this field. In this paper, the study reports for the first time, the use of Ag0.33V2O5 as a cathode material in aqueous manganese batteries. The study explains the displacement/intercalation behavior of manganese and silver using electrochemical, structural, and spectroscopic analyses. Additionally, it is shown that cation (Ag+, Mn2+, H+) diffusion pathways can be simulated using diffusion‐barrier calculations. Finally, the study demonstrates high‐performance manganese batteries that exhibit a remarkable reversible capacity of ≈261.9 mAh g−1 at a current of 0.1 A g−1 and an excellent cycle retention of 69.1% after 2000 cycles at a current density of 1.5 A/g. The findings of this study contribute to the advancement of aqueous manganese battery technology, offering a promising pathway for developing safer, more cost‐effective, and high‐performance energy storage systems.
Miniature Modular Reconfigurable Underwater Robot Based on Synthetic Jet
Authors: Wang Dehong , Zhang Fanheng , Zhang Shijing , Liu Daqing , Li Jing , Chen Weishan , Deng Jie , Liu Yingxiang 
Published: August 2024

AbstractModular reconfigurable robots exhibit prominent advantages in the reconnaissance and exploration tasks within unstructured environments for their characteristics of high adaptability and high robustness. However, due to the limitations in locomotion mechanism and integration requirements, the modular design of miniature robots in the aquatic environment encounters significant challenges. Here, a modular strategy based on the synthetic jet principle is proposed, and a modular reconfigurable robot system is developed. Specialized bottom and side jet actuators are designed with vibration motors as excitation sources, and a motion module is developed incorporating the jet actuators to realize three‐dimensional agile motion. Its linear, rotational, and ascending motion speeds reach 70.7 mm s−1, 3.3 rad s−1, and 28.7 mm s−1, respectively. The module integrates the power supply, communication, and control system with a small size of 48 mm × 38 mm × 38 mm, which ensures a wireless controllable motion. Then, various configurations of the multi‐module robot system are established with corresponding motion schemes, and the experiments with replaceable intermediate modules are further conducted to verify the transportation and image‐capturing functions. This work demonstrates the effectiveness of synthetic jet propulsion for aquatic modular reconfigurable robot systems, and it exhibits profound potential in future underwater applications.