bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized, crossover, placebo-controlled clinical trial to assess the sensitivity of the CRCDS Mini-Sim to the next-day residual effects of zopiclone
Authors: Simen Arthur A. , Gargano Cynthia , Cha Jang-Ho , Drexel Melissa , Bautmans An , Heirman Ingeborg , Laethem Tine , Hochadel Thomas , Gheyle Lien , Bleys Kim , Beals Chan , Stoch Aubrey , Kay Gary G. , Struyk Arie 
Published: April 2015

Objectives: We sought to validate Cognitive Research Corporation’s Driving Simulator (CRCDS Mini-Sim) for studies of drug safety with respect to driving ability. Methods: A total of 30 healthy subjects were randomized to receive placebo or 7.5 mg zopiclone, a hypnotic known to impair driving, in random order during the 2 treatment periods of a 2 period crossover design. Results: Evening administration of 7.5 mg zopiclone increased next-day standard deviation of lateral lane position (SDLP) by 2.62 cm on average compared with evening administration of placebo, and caused significant effects on symmetry analysis. The magnitude of the change in SDLP is highly similar to changes previously observed using on-the-road driving methods. Conclusions: Further validation of the CRCDS Mini-Sim is warranted to develop this platform for drug safety studies.
Injury Types and Incidence Rates in Precollegiate Female Gymnasts
Authors: Saluan Paul , Styron Joseph , Ackley J. Freeland , Prinzbach Arianna , Billow Damien 
Published: April 2015

Background: With childhood sports opportunities continuing to increase at an enormous rate along with participation starting at younger ages, the number of female participants in sports has increased in paramount fashion over the past few decades. A review of the current literature reveals a very small number of studies (<30) that document specific injuries suffered by competitive female gymnasts. Purpose: To retrospectively evaluate the incidence of various injuries and injury rates for different gymnast levels among young precollegiate female gymnasts over a 21-year period, from 1985 to 2005. Study Design: Descriptive epidemiological study. Methods: This institutional review board–approved study retrospectively evaluated young, precollegiate female gymnasts over a 21-year period. Gymnasts were stratified into 1 of 4 competition levels based on the number of hours spent training. In addition to the frequency of injuries and hours trained, data collected on each gymnast included the following: age at the time of injury, body part injured, laterality of the injury, and diagnosis. Results: Over the 21-year period, 3681 new injuries were evaluated by a single physician. The injury incidence (2.155 per 1000 exposure hours) was slightly lower when compared with previously reported injury rates. There were 1,452,574 total exposure hours documented from training facility records. The injury rate per 1000 exposure hours was 2.859 for elite, 2.820 for high-level, 1.667 for intermediate, and 0.687 for novice gymnasts. The lower extremity was injured more often than the upper extremity (60.9% compared with 22.6% of total injuries). This difference was statistically significant across all levels. Conclusion: The injury incidence in this study was 2.155 per 1000 exposure hours. This was slightly lower when compared with previously reported injury rates. Although those studies only lasted 3 years or less, the injury rates can be directly compared because they are reported as injuries per 1000 training hours. Clinical Relevance: With the variability in data available and limited studies reported, a conclusive analysis is needed because of the long-term effects of injury seen on gymnasts, such as early degenerative disorders, cost of injury treatment, and reduction of well-being. In our 21-year study, we found the incidence of injury was slightly lower than that shown in prior shorter studies. In addition, we were able to evaluate specific injuries seen in this population over that time period. Also, this extended study revealed the longitudinal nature of a series of injuries over a period of time that has not been seen in other studies, thus giving insight into the effects of increased gymnastics in the young, female, adolescent population, which could be potentially used in guidelines for gymnasts in the future.
T memory stem cells are the hierarchical apex of adult T-cell leukemia
Authors: Nagai Yuya , Kawahara Masahiro , Hishizawa Masakatsu , Shimazu Yayoi , Sugino Noriko , Fujii Sumie , Kadowaki Norimitsu , Takaori-Kondo Akifumi 
Published: April 2015

Key Points
ATL clones are preserved in a rare CD4+CD45RA+ TSCM population. ATL-TSCM cells unidirectionally produce conventional CD45RO+ ATL cells and show a high potency of repopulating identical ATL clones in vivo.
The impact of ultra-low amounts of amino-modified MMT on dynamics and properties of densely cross-linked cyanate ester resins
Authors: Bershtein Vladimir , Fainleib Alexander , Egorova Larisa , Gusakova Kristina , Grigoryeva Olga , Kirilenko Demid , Konnikov Semen , Ryzhov Valery , Yakushev Pavel , Lavrenyuk Natalia 
Published: April 2015

Abstract
Thermostable nanocomposites based on densely cross-linked cyanate ester resins (CER), derived from bisphenol E and doped by 0.01 to 5 wt. % amino-functionalized 2D montmorillonite (MMT) nanoparticles, were synthesized and characterized using Fourier transform infrared (FTIR), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDXS), wide-angle X-ray diffraction (WAXD), dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), far-infrared (Far-IR), and creep rate spectroscopy (CRS) techniques. It was revealed that ultra-low additives, e.g., 0.025 to 0.1 wt. %, of amino-MMT nanolayers covalently embedded into СER network exerted an anomalously large impact on its dynamics and properties resulting, in particular, in some suppression of dynamics, increasing the onset of glass transition temperature by 30° to 40° and twofold rise of modulus in temperature range from 20°C to 200°C. Contrarily, the effects became negligibly small or even negative at increased amino-MMT contents, especially at 2 and 5 wt. %. That could be explained by TEM/EDXS data displaying predominance of individual amino-MMT nanolayers and their thin (2 to 3 nanolayers) stacks over more thick tactoids (5 to 10 nanolayers) and the large amino-MMT aggregates (100 to 500 nm in thickness) reversing the composite structure produced with increasing of amino-MMT content within CER matrix. The revealed effect of ultra-low amino-MMT content testifies in favor of the idea about the extraordinarily enhanced long-range action of the ‘constrained dynamics’ effect in the case of densely cross-linked polymer networks.

PACS
82.35.Np Nanoparticles in polymers; 81.05.Qk Reinforced polymers and polymer-based composites; 81.07.Pr Organic-inorganic hybrid nanostructures
Detecting non-allelic homologous recombination from high-throughput sequencing data
Authors: Parks Matthew M , Lawrence Charles E , Raphael Benjamin J 
Published: April 2015

AbstractNon-allelic homologous recombination (NAHR) is a common mechanism for generating genome rearrangements and is implicated in numerous genetic disorders, but its detection in high-throughput sequencing data poses a serious challenge. We present a probabilistic model of NAHR and demonstrate its ability to find NAHR in low-coverage sequencing data from 44 individuals. We identify NAHR-mediated deletions or duplications in 109 of 324 potential NAHR loci in at least one of the individuals. These calls segregate by ancestry, are more common in closely spaced repeats, often result in duplicated genes or pseudogenes, and affect highly studied genes such as GBA and CYP2E1.
Concerns About Cancer Risk and Experiences With Genetic Testing in a Diverse Population of Patients With Breast Cancer
Authors: Jagsi Reshma , Griffith Kent A. , Kurian Allison W. , Morrow Monica , Hamilton Ann S. , Graff John J. , Katz Steven J. , Hawley Sarah T. 
Published: April 2015

PurposeTo evaluate preferences for and experiences with genetic testing in a diverse cohort of patients with breast cancer identified through population-based registries, with attention to differences by race/ethnicity.MethodsWe surveyed women diagnosed with nonmetastatic breast cancer from 2005 to 2007, as reported to the SEER registries of metropolitan Los Angeles and Detroit, about experiences with hereditary risk evaluation. Multivariable models evaluated correlates of a strong desire for genetic testing, unmet need for discussion with a health care professional, and receipt of testing.ResultsAmong 1,536 patients who completed the survey, 35% expressed strong desire for genetic testing, 28% reported discussing testing with a health care professional, and 19% reported test receipt. Strong desire for testing was more common in younger women, Latinas, and those with family history. Minority patients were significantly more likely to have unmet need for discussion (failure to discuss genetic testing with a health professional when they had a strong desire for testing): odds ratios of 1.68, 2.44, and 7.39 for blacks, English-speaking Latinas, and Spanish-speaking Latinas compared with whites, respectively. Worry in the long-term survivorship period was higher among those with unmet need for discussion (48.7% v 24.9%; P <.001). Patients who received genetic testing were younger, less likely to be black, and more likely to have a family cancer history.ConclusionMany patients, especially minorities, express a strong desire for genetic testing and may benefit from discussion to clarify risks. Clinicians should discuss genetic risk even with patients they perceive to be at low risk, as this may reduce worry.
Oocyte Induction of EGF Responsiveness in Somatic Cells Is Associated With the Acquisition of Porcine Oocyte Developmental Competence
Authors: Ritter Lesley J. , Sugimura Satoshi , Gilchrist Robert B. 
Published: April 2015

Abstract
Oocytes progressively acquire the competence to support embryo development as oogenesis proceeds with ovarian folliculogenesis. The objectives of this study were to investigate oocyte-secreted factor (OSF) participation in the development of somatic cell epidermal growth factor (EGF) responsiveness associated with oocyte developmental competence. A well-established porcine model was employed using oocytes from small (&lt;4 mm) vs medium sized (&gt;4 mm) antral follicles, representing low vs moderate developmental competence, respectively. Cumulus-oocyte complexes (COCs) were treated in vitro with inducers of oocyte maturation, and cumulus cell functions and oocyte developmental competence were assessed. COCs from small follicles responded to FSH but, unlike COCs from larger follicles, were incapable of responding to EGF family growth factors known to mediate oocyte maturation in vivo, exhibiting perturbed cumulus expansion and expression of associated transcripts (HAS2 and TNFAIP6). Low and moderate competence COCs expressed equivalent levels of EGF receptor (EGFR) mRNA; however, the former had less total EGFR protein leading to failed activation of phospho-EGFR and phospho-ERK1/2, despite equivalent total ERK1/2 protein levels. Native OSFs from moderate, but not from low, competence oocytes established EGF responsiveness in low competence COCs. Four candidate recombinant OSFs failed to mimic the actions of native OSFs in regulating cumulus expansion. Treatment with OSFs and EGF enhanced oocyte competence but only of the low competence COCs. These data suggest that developmental acquisition by the oocyte of capacity to regulate EGF responsiveness in the oocyte's somatic cells is a major milestone in the oocyte's developmental program and contributes to coordinated oocyte and somatic cell development.
Determinant of Foreign Direct Investment into Developing Countries in the Circumstance of Globalization
Authors: Данг  , Dang May An 
Published: April 2015

Foreign investment, especially FDI plays a role more and more important for economic growth and
international integration. However, the flux of FDI in the world is influenced by many determinants such as the
population, GDP, the education level, the law on intellectual property right… Analyzing these determinants
of FDI could contribute to find out the trend of global FDI and the solutions for developing countries to attract
more FDI for economic growth.
The Role of International Standards in the Development of Global Value Chains
Authors: Зуев  , Zuev V. , Островская  , Ostrovskaya Yelyena , Мануйлов  , Manuylov I. 
Published: April 2015

This paper is devoted to the influence of standardization on emergence and development of global value
chains (GVC). Nowadays trade in value added is the subject for heated debates. However, the role of
standardization (in particular, international standardization) is highly underestimated. The study examines
the history of the development of different types of standards, comparing different approaches to modeling
the processes of standardization and develops recommendations for the economic policy of Russia on the
basis of its present position in the GVC. At the moment, we can say unambiguously that standardization leads
to the shift of firms from upstream stages of production to the field of design and marketing, where a greater
chance to realize competitive advantages exists (downstream stages). For Russia, it means continuous
improvement in the following areas: the development of large and small businesses in sectors that are
not related to the energy, encouraging companies to establish supply chains and value chains, customer
orientated businesses. In addition to the positive effects of standardization, the article also reviews some
negative shocks. They occur when the standards are being introduced to small firms, or when accepted
standards are not harmonized in accordance with international standards, or when there are no resources
for modernization within the global value chain, or when there are no opportunities to move into new markets
where standardization is lower, or when different standards are set to reach controversial objectives.
Nevertheless, in all these cases, there are certain conditions which implementation will make standardization
the most effective. These include, for example, a balance between the amount of the factor used in the
production and the complexity of the technology. This condition is explained here both mathematically and
by the example of the Chinese national program for certification of organic products. Thus, the importance
of international standardization for the development of global value chains cannot be overstated, despite
possible negative effects. That is why Russia should be actively involved in all of these processes in order
to stimulate economic growth.
Data driven fault detection and isolation: a wind turbine scenario
Authors: Manrique Piramanrique Rubén Francisco , Sofrony Esmeral Jorge 
Published: April 2015

Uno de los mayores inconvenientes presentes en la generación de energía eólica son los altos costos de mantenimiento asociados a fallas mecánicas. Este problema se hace más evidente en las turbinas de viento de escala industrial, en donde incrementos en el tamaño y la capacidad nominal traen consigo problemas adicionales asociados a vibraciones estructurales y efectos aeroelásticos en las hojas. Debido al incremento en la capacidad de operación, es imprescindible detectar de manera eficiente fallas y degradaciones en el sistema, garantizando la integridad, su fiabilidad y reduciendo los costos de operación. Este artículo presenta un sistema para la detección y aislamiento de fallas (FDI), basado en técnicas "Guiadas por los datos " (Data driven, abreviado DD). La arquitectura propuesta es una estrategia de varios niveles en donde: (i) el primer nivel detecta la ocurrencia de una falla (detección), mientras que (ii) el segundo identifica su origen (aislamiento). Se estudiaron y compararon cuatro técnicas de clasificación para cada uno de los niveles (Máquinas de Vectores de Soporte, Redes Neuronales Artificiales, K vecinos cercanos y Mezcla de Gaussianas). La mejor estrategia en cada nivel fue seleccionada para construir el sistema FDI. El rendimiento del sistema propuesto se evalúa en un modelo de referencia de una turbina eólica de escala comercial.
Análisis estocástico de señales vibratorias de motores de inducción para la detección de fallas usando descomposición de modo empírico
Authors: Rivera Roldán Alejandro , Becerra Botero Miguel Alberto , Guzmán Luna Jaime Alberto 
Published: April 2015

En este artículo se presenta un análisis de vibraciones en motores de inducción por medio de Modelos Ocultos de Markov (Hidden Markov Model - HMM) aplicado a características obtenidas de la Descomposición de Modo Empírico (Empirical Mode Decomposition - EMD) y transformada de Hilbert-Huang de señales de vibración obtenidas en las coordenadas x y y, con el fin de detectar fallas de funcionamiento en rodamientos y barras. Además se presenta un análisis comparativo de la capacidad de las señales de vibración en dirección x y en dirección y, para aportar información en la detección de fallas. Así, un HMM ergódico inicializado y entrenado por medio del algoritmo de máxima esperanza, con convergencia en 10e-7 y un máximo de iteraciones de 100, se aplicó sobre el espacio de características y su desempeño fue determinado mediante validación cruzada 80-20 con 30 fold, obteniendo un alto desempeño para la detección de fallas en términos de exactitud.
Theoretic similitude of the aerobic biological growth kinetics for the stabilization of organic matter in wastewaters treatment
Authors: Rodríguez Miranda Juan Pablo , García Ubaque Cesar Augusto , García Vaca María Camila 
Published: April 2015

Para la estabilización de la materia orgánica en el tratamiento de las aguas residuales no solo es significativo establecer la cinética de crecimiento microbiano sino la interrelación de la remoción de nutrientes como el nitrógeno, dada la similitud de coeficientes, tasa de crecimiento específica y los ajustes por temperatura del agua, que lo representa tanto para la remoción de la materia orgánica como para los procesos de nitrificación y denitrificación presentes en el tratamiento biológico de las aguas residuales. Por ello, esta similitud teórica de las cinéticas de crecimiento microbiano y de los procesos de remoción de nitrógeno constituye consideraciones concisas para el proceso de dimensionamiento de sistemas de tratamiento biológicos de tratamiento de aguas residuales, que ayudan a entender el proceso simultáneo de remover materia orgánica y nutrientes del agua residual cruda.
Division pairs: a new approach to Moufang sets
Authors: Loos Ottmar 
Published: April 2015

Abstract
The concept of division pairs, a non-abelian version of Jordan division pairs, is introduced and a categorical equivalence between division pairs and Moufang sets is established. This is used to explain the non-uniqueness occurring in the description of Moufang sets in terms of pairs (U, τ) initiated by De Medts and Weiss.
Real solutions to systems of polynomial equations and parameter continuation
Authors: Griffin Zachary A. , Hauenstein Jonathan D. 
Published: April 2015

Abstract
Given a parameterized family of polynomial equations, a fundamental question is to determine upper and lower bounds on the number of real solutions a member of this family can have and, if possible, compute where the bounds are sharp. A computational approach to this problem was developed by Dietmaier in 1998 who used a local linearization procedure to move in the parameter space to change the number of real solutions. He used this approach to show that there exists a Stewart-Gough platform that attains the maximum of forty real assembly modes. Due to the necessary ill-conditioning near the discriminant locus, we propose replacing the local linearization near the discriminant locus with a homotopy-based method derived from the method of gradient descent arising in optimization. This new hybrid approach is then used to develop a new result in real enumerative geometry.
TriPleX: a versatile dielectric photonic platform
Authors: Wörhoff Kerstin , Heideman René G. , Leinse Arne , Hoekman Marcel 
Published: April 2015

Abstract
Photonic applications based on planar waveguide technology impose stringent requirements on properties such as optical propagation losses, light coupling to optical fibers, integration density, as well as on reliability and reproducibility. The latter is correlated to a high level of control of the refractive index and waveguide geometry. In this paper, we review a versatile dielectric waveguide platform, called TriPleX, which is based on alternating silicon nitride and silicon dioxide films. Fabrication with CMOS-compatible equipment based on low-pressure chemical vapor deposition enables the realization of stable material compositions being a prerequisite to the control of waveguide properties and modal shape. The transparency window of both materials allows for the realization of low-loss waveguides over a wide wavelength range (400 nm–2.35 μm). Propagation losses as low as 5×10-4 dB/cm are reported. Three basic geometries (box shell, double stripe, and filled box) can be distinguished. A specific tapering technology is developed for on-chip, low-loss (<0.1 dB) spotsize convertors, allowing for combining efficient fiber to chip coupling with high-contrast waveguides required for increased functional complexity as well as for hybrid integration with other photonic platforms such as InP and SOI. The functionality of the TriPleX platform is captured by verified basic building blocks. The corresponding library and associated design kit is available for multi-project wafer (MPW) runs. Several applications of this platform technology in communications, biomedicine, sensing, as well as a few special fields of photonics are treated in more detail.
Household saving in Australia
Authors: Finlay Richard , Price Fiona 
Published: April 2015

AbstractThis paper investigates household saving behavior in Australia, as well as the drivers behind the recent rise in the aggregate household saving ratio. Our results explaining differences in saving behavior across households are consistent with theory and previous findings. As might be expected, households’ saving ratios tend to increase with income, but decrease with wealth and gearing. More at-risk households such as single-parent and migrant households tend to save more than other households, all else being equal. While saving differs substantially across age groups we find that, at least in part, this reflects differing circumstances. Our results suggest that the rise in household saving between 2003/2004 and 2009/2010 was driven by changes in behavior rather than changes in population characteristics: in particular, more educated households, as well as households with high debt and/or wealth increased their propensity to save. Our interpretation of these results is that a reduction in future income growth expectations for more highly educated households after the financial crisis, and an associated effort to rebuild wealth and repay debt, drove to the aggregate rise in household saving.