bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infective endocarditis: call for education of adults with CHD: review of the evidence
Authors: Hays Laura H. 
Published: November 2015

AbstractAdvanced surgical repair procedures have resulted in the increased survival rate to adulthood of patients with CHD. The resulting new chronic conditions population is greater than one million in the United States of America and >1.2 million in Europe. This review describes the risks and effects of infective endocarditis – a systemic infectious process with high morbidity and mortality – on this population and examines the evidence to determine whether greater patient education on recognition of symptoms and preventative measures is warranted. The literature search included the terms “infective endocarditis” and “adult congenital heart disease”. Search refinement, the addition of articles cited by included articles, as well as addition of supporting articles, resulted in utilisation of 24 articles. Infective endocarditis, defined by the modified Duke Criteria, occurs at a significantly higher rate in the CHD population due to congenitally or surgically altered cardiac anatomies and placement of prosthetic valves. This literature review returned no studies in the past five years assessing knowledge of the definition, recognition of symptoms, and preventative measures of infective endocarditis in the adult CHD population. Existing data are more than 15 years old and show significant knowledge deficits. Studies have consistently shown the need for improved CHD patient knowledge with regard to infective endocarditis, and there is no recent evidence that these knowledge deficits have decreased. It is important to address and decrease knowledge deficits in order to improve patient outcomes and decrease healthcare utilisation and costs.
Pulmonary toxicity following total body irradiation for acute lymphoblastic leukaemia: The Ottawa Hospital Cancer Centre (TOHCC) experience
Authors: Ujaimi R. K. , Isfahanian N. , Russa D. J. La , Samant R. , Bredeson C. , Genest P. 
Published: November 2015

AbstractPurposeTo review the incidence of clinically significant pulmonary toxicity following total body irradiation (TBI) as a part of the conditioning regimen for acute lymphoblastic leukaemia (ALL) patients undergoing bone marrow transplantation (BMT) at The Ottawa Hospital Cancer Centre.MethodsThis is a retrospective review of ALL patients who received TBI in The Ottawa Hospital Bone Marrow Transplant Program (TOH-BMT) as part of their conditioning regimen from 1991 to 2011 inclusive. The patients were treated using a locally developed translating-couch irradiation technique. We have analysed all available data for the first 100 days following TBI to determine the incidence of radiation-induced pulmonary toxicities.ResultsOf the total 622 patients undergoing TBI during the specified period, 88 had ALL. Median age at BMT was 30 years and the conditioning regimens varied. A total of 74 (84%) patients received 12 Gy/6 F/BID of TBI. A total of 55 (63%) patients have died, 32 (36%) within the 1st year after BMT. In the 1st year, pulmonary events were reported for 24 (27%) patients, and the follow-up notes were unavailable for seven (8%). Pulmonary toxicities were reported as the cause of death for six patients, five (6%) within the 1st year. It is estimated that the total number of deaths in the 1st year possibly attributed to radiation-induced lung injury was four (4·5%). Eight (9%) patients had symptoms suggestive of non-lethal grade 2–3 radiation-induced pneumonitis.ConclusionsTBI continues to be an important component of the conditioning regimen for ALL patients undergoing BMT, and the incidence of radiation-induced pulmonary injury, using our technique and lung dose, is comparable to the published literature.
A social systems approach to understanding the racial effect of the Section 44 counter-terror stop and search powers
Authors: Herron Rachel 
Published: November 2015

AbstractIn 2010, the European Court of Human Rights (ECtHR) endorsed long-standing claims of the potentially discriminatory effect of the suspicionless stop and search powers within s.44 of the Terrorism Act 2000. This paper applies principles of social systems theory to propose an explanation for the empirically evidenced racial effect of the s.44 police powers. Through observations regarding communicative barriers apparent between the law-making and policing subsystems, the paper argues that each subsystem's understanding of the expectations of the other, pertaining to the nature and use of the s.44 powers, contributed to their deployment in a way that diminished the effectiveness of the safeguards intended to guard against their misuse. Mismatched subsystem expectations meant that the powers were implemented by the police without the statutory protections, the operational self-restraint, or the type of intelligence-led judgment expected by the legislature, giving rise to misuse of the powers and, in particular, their deployment in line with race-based profiles.
How far is too far? Theorising non-conviction-based asset forfeiture
Authors: Hendry Jennifer , King Colin 
Published: November 2015

AbstractNon-conviction-based (NCB) asset forfeiture is a relatively recent addition to law enforcement's armoury in the fight against organised crime in the UK. It allows for criminal assets to be forfeited to the State even in the absence of criminal conviction, the stated objective being to undermine the profit incentive of criminal activity. Until now, NCB asset forfeiture has principally been critiqued from a criminological point of view, specifically concerning the Packer models and the civil/criminal dichotomy – aside from this, however, it remains rather underdeveloped theoretically. This paper addresses this lack of legal theoretical engagement with NCB asset forfeiture by providing an initial contribution from a systems-theoretical perspective. This contribution makes use of systems theory's unique insights to critique the perceived ‘failure of law’ that gave rise to the NCB approach, and challenges the legitimacy of that approach in terms of procedural rights.
Civil disobedience and constituent power
Authors: Nobles Richard , Schiff David 
Published: November 2015

AbstractThis paper uses the example of civil disobedience to explore Luhmann's description of the constitution as structural coupling between law and politics. Civil disobedience highlights the paradox of constituent and constituted power. The claims made for constituent power provide a basis for challenging the current configuration and expression of constituted power. This paradox is first avoided in the legal system through that system's inability to recognise a legal right to disobey law. In turn, a political system that has, under conditions of modernity, increasingly second coded power as legality, has an ever decreasing capacity to include communications that acknowledge a right to disobey law. Civil disobedience is only able to operate within the political system in the form of protest, and is accommodated through the exercise of discretionary powers. However, juridification of those powers has the capacity to threaten this accommodation.
Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves
Authors: Collins David J. , Morahan Belinda , Garcia-Bustos Jose , Doerig Christian , Plebanski Magdalena , Neild Adrian 
Published: November 2015

AbstractIn single-cell analysis, cellular activity and parameters are assayed on an individual, rather than population-average basis. Essential to observing the activity of these cells over time is the ability to trap, pattern and retain them, for which previous single-cell-patterning work has principally made use of mechanical methods. While successful as a long-term cell-patterning strategy, these devices remain essentially single use. Here we introduce a new method for the patterning of multiple spatially separated single particles and cells using high-frequency acoustic fields with one cell per acoustic well. We characterize and demonstrate patterning for both a range of particle sizes and the capture and patterning of cells, including human lymphocytes and red blood cells infected by the malarial parasitePlasmodium falciparum. This ability is made possible by a hitherto unexplored regime where the acoustic wavelength is on the same order as the cell dimensions.
Compound heterozygous mutations in the noncoding RNU4ATAC cause Roifman Syndrome by disrupting minor intron splicing
Authors: Merico Daniele , Roifman Maian , Braunschweig Ulrich , Yuen Ryan K. C. , Alexandrova Roumiana , Bates Andrea , Reid Brenda , Nalpathamkalam Thomas , Wang Zhuozhi , Thiruvahindrapuram Bhooma , Gray Paul , Kakakios Alyson , Peake Jane , Hogarth Stephanie , Manson David , Buncic Raymond , Pereira Sergio L. , Herbrick Jo-Anne , Blencowe Benjamin J. , Roifman Chaim M. , Scherer Stephen W. 
Published: November 2015

AbstractRoifman Syndrome is a rare congenital disorder characterized by growth retardation, cognitive delay, spondyloepiphyseal dysplasia and antibody deficiency. Here we utilize whole-genome sequencing of Roifman Syndrome patients to reveal compound heterozygous rare variants that disrupt highly conserved positions of the RNU4ATAC small nuclear RNA gene, a minor spliceosome component that is essential for minor intron splicing. Targeted sequencing confirms allele segregation in six cases from four unrelated families. RNU4ATAC rare variants have been recently reported to cause microcephalic osteodysplastic primordial dwarfism, type I (MOPD1), whose phenotype is distinct from Roifman Syndrome. Strikingly, all six of the Roifman Syndrome cases have one variant that overlaps MOPD1-implicated structural elements, while the other variant overlaps a highly conserved structural element not previously implicated in disease. RNA-seq analysis confirms extensive and specific defects of minor intron splicing. Available allele frequency data suggest that recessive genetic disorders caused by RNU4ATAC rare variants may be more prevalent than previously reported.
Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
Authors: Lussey-Lepoutre Charlotte , Hollinshead Kate E. R. , Ludwig Christian , Menara Mélanie , Morin Aurélie , Castro-Vega Luis-Jaime , Parker Seth J. , Janin Maxime , Martinelli Cosimo , Ottolenghi Chris , Metallo Christian , Gimenez-Roqueplo Anne-Paule , Favier Judith , Tennant Daniel A. 
Published: November 2015

AbstractThe tricarboxylic acid (TCA) cycle is a central metabolic pathway responsible for supplying reducing potential for oxidative phosphorylation and anabolic substrates for cell growth, repair and proliferation. As such it thought to be essential for cell proliferation and tissue homeostasis. However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Here, we show that loss of SDH activity leads to changes in the metabolism of non-essential amino acids. In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool of aspartate in SDH-deficient cells. Our results demonstrate that the loss of SDH reduces the metabolic plasticity of cells, suggesting vulnerabilities that can be targeted therapeutically.
Human Odorant Reception in the Common Bed Bug, Cimex lectularius
Authors: Liu Feng , Liu Nannan 
Published: November 2015

AbstractThe common bed bug Cimex lectularius is a temporary ectoparasite on humans and currently resurgent in many developed countries. The ability of bed bugs to detect human odorants in the environment is critical for their host-seeking behavior. This study deciphered the chemical basis of host detection by investigating the neuronal response of olfactory sensilla to 104 human odorants using single sensillum recording and characterized the electro-physiological responses of bed bug odorant receptors to human odorants with the Xenopus expression system. The results showed that the D type of olfactory sensilla play a predominant role in detecting the human odorants tested. Different human odorants elicited different neuronal responses with different firing frequencies and temporal dynamics. Particularly, aldehydes and alcohols are the most effective stimuli in triggering strong response while none of the carboxylic acids showed a strong stimulation. Functional characterization of two bed bug odorant receptors and co-receptors in response to human odorants revealed their specific responses to the aldehyde human odorants. Taken together, the findings of this study not only provide exciting new insights into the human odorant detection of bed bugs, but also offer valuable information for developing new reagents (attractants or repellents) for the bed bug control.
Using metamaterial nanoengineering to triple the superconducting critical temperature of bulk aluminum
Authors: Smolyaninova Vera N. , Zander Kathryn , Gresock Thomas , Jensen Christopher , Prestigiacomo Joseph C. , Osofsky M. S. , Smolyaninov Igor I. 
Published: November 2015

AbstractRecent experiments have shown the viability of the metamaterial approach to dielectric response engineering for enhancing the transition temperature, Tc, of a superconductor. In this report, we demonstrate the use of Al2O3-coated aluminium nanoparticles to form the recently proposed epsilon near zero (ENZ) core-shell metamaterial superconductor with a Tc that is three times that of pure aluminium. IR reflectivity measurements confirm the predicted metamaterial modification of the dielectric function thus demonstrating the efficacy of the ENZ metamaterial approach to Tc engineering. The developed technology enables efficient nanofabrication of bulk aluminium-based metamaterial superconductors. These results open up numerous new possibilities of considerable Tc increase in other simple superconductors.
Physical realization of the Glauber quantum oscillator
Authors: Gentilini Silvia , Braidotti Maria Chiara , Marcucci Giulia , DelRe Eugenio , Conti Claudio 
Published: November 2015

AbstractMore than thirty years ago Glauber suggested that the link between the reversible microscopic and the irreversible macroscopic world can be formulated in physical terms through an inverted harmonic oscillator describing quantum amplifiers. Further theoretical studies have shown that the paradigm for irreversibility is indeed the reversed harmonic oscillator. As outlined by Glauber, providing experimental evidence of these idealized physical systems could open the way to a variety of fundamental studies, for example to simulate irreversible quantum dynamics and explain the arrow of time. However, supporting experimental evidence of reversed quantized oscillators is lacking. We report the direct observation of exploding n = 0 and n = 2 discrete states and Γ0 and Γ2 quantized decay rates of a reversed harmonic oscillator generated by an optical photothermal nonlinearity. Our results give experimental validation to the main prediction of irreversible quantum mechanics, that is, the existence of states with quantized decay rates. Our results also provide a novel perspective to optical shock-waves, potentially useful for applications as lasers, optical amplifiers, white-light and X-ray generation.
Strongly polarizing weakly coupled 13C nuclear spins with optically pumped nitrogen-vacancy center
Authors: Wang Ping , Liu Bao , Yang Wen 
Published: November 2015

AbstractEnhancing the polarization of nuclear spins surrounding the nitrogen-vacancy (NV) center in diamond has recently attracted widespread attention due to its various applications. Here we present an analytical formula that not only provides a clear physical picture for the recently observed polarization reversal of strongly coupled13C nuclei over a narrow range of magnetic field [H. J. Wang et al., Nat. Commun. 4, 1940 (2013)], but also demonstrates the possibility to strongly polarize weakly coupled13C nuclei. This allows sensitive magnetic field control of the 13C nuclear spin polarization for NMR applications and significant suppression of the 13C nuclear spin noise to prolong the NV spin coherence time.
Elasticity of polymeric nanocolloidal particles
Authors: Riest Jonas , Athanasopoulou Labrini , Egorov Sergei A. , Likos Christos N. , Ziherl Primož 
Published: November 2015

AbstractSoftness is an essential mechanical feature of macromolecular particles such as polymer-grafted nanocolloids, polyelectrolyte networks, cross-linked microgels as well as block copolymer and dendrimer micelles. Elasticity of individual particles directly controls their swelling, wetting and adsorption behaviour, their aggregation and self-assembly as well as structural and rheological properties of suspensions. Here we use numerical simulations and self-consistent field theory to study the deformation behaviour of a single spherical polymer brush upon diametral compression. We observe a universal response, which is rationalised using scaling arguments and interpreted in terms of two coarse-grained models. At small and intermediate compressions the deformation can be accurately reproduced by modelling the brush as a liquid drop, whereas at large compressions the brush behaves as a soft ball. Applicable far beyond the pairwise-additive small-strain regime, the models may be used to describe microelasticity of nanocolloids in severe confinement including dense disordered and crystalline phases.
Quantum-electrodynamical birefringence vanishing in a thermal relativistic pair plasma
Authors: Huang Y. S. 
Published: November 2015

AbstractQuantum electrodynamical (QED) birefringence in a thermal relativistic pair plasma with the presence of the strong crossed field: "Equation missing", is proposed and investigated. We clarify the coupling relationship and competition between the QED effect and the plasma collective effect and find the critical condition that makes the birefringence vanish. In a relative weak electromagnetic field, the birefringence is dominated by the coupling of the QED-effect, the collective effect and the "Equation missing" drift effect. In a relative strong electromagnetic field, we obtain the formulations stating the competition between the QED effect and the collective effect and then the critical conditions so that they are canceled with each other and the birefringence vanishes. With our results, a new possible scheme is proposed to estimate the thickness of the magnetosphere in a millisecond pulsar and the plasma density of a pulsar, if the magnetic field is known beforehand.
Mechanism of bombesin-induced tonic contraction of the porcine lower esophageal sphincter
Authors: Tsai Ching-Chung , Chang Li-Ching , Lin Kai-Jen , Tey Shu-Leei , Su Yu-Tsun , Liu Ching-Wen , Tsai Tong-Rong , Huang Shih-Che 
Published: November 2015

AbstractGastroesophageal reflux disease (GERD) is a disorder that is related to an incompetent lower esophageal sphincter (LES). Previous studies showed that bombesin could increase LES pressure in humans and opossums. The aim of the present study was to characterize the effects of bombesin on porcine LES contraction. We used the selective agonists, neuromedin B (NMB), gastrin-releasing peptide (GRP) and [D-Tyr6,Apa-4Cl11,Phe13,Nle14]bombesin-(6-14) (DTACPN-BN), as well as receptor antagonists of bombesin receptor subtype 2 (BB2) and 3 (BB3) for ex vivo contraction studies. Atropine, nifedipine, tetrodotoxin and ω-conotoxin GVIA were used to explore the agonist-induced LES contraction mechanism. Reverse transcription polymerase chain reaction and immunohistochemistry were applied to detect bombesin receptor expression. Our results indicate that GRP and DTACPN-BN, but not NMB, induced tonic contractions of the porcine LES in a dose-dependent manner and the contractions were inhibited with selective BB2 and BB3 antagonists. The GRP-induced contraction is mainly caused by L-type Ca2+ channel-mediated Ca2+ influx. However, DTACPN-BN-induced contractions are associated with neuronal conduction. RT-PCR and immunohistochemistry revealed that BB2 and BB3 were expressed in the porcine LES. Bombesin-induced tonic contraction of the LES is mediated through BB2 and BB3. Bombesin, BB2, and BB3 agonists might have the potential to treat GERD.
Initial amplification of the HPV18 genome proceeds via two distinct replication mechanisms
Authors: Orav Marit , Geimanen Jelizaveta , Sepp Eva-Maria , Henno Liisi , Ustav Ene , Ustav Mart 
Published: November 2015

AbstractDetermining the mechanism of HPV18 replication is paramount for identifying possible drug targets against HPV infection. We used two-dimensional and three-dimensional gel electrophoresis techniques to identify replication intermediates arising during the initial amplification of HPV18 episomal genomes. We determined that the first rounds of HPV18 replication proceed via bidirectional theta structures; however, a notable accumulation of almost fully replicated HPV18 genomes indicates difficulties with the completion of theta replication. We also observed intermediates that were created by a second replication mechanism during the initial amplification of HPV18 genomes. The second replication mechanism does not utilize specific initiation or termination sequences and proceeds via a unidirectional replication fork. We suggest a significant role for the second replication mechanism during the initial replication of the HPV18 genome and propose that the second replication mechanism is recombination-dependent replication.
Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons
Authors: Whitlon Donna S. , Grover Mary , Dunne Sara F. , Richter Sonja , Luan Chi-Hao , Richter Claus-Peter 
Published: November 2015

AbstractThe bipolar spiral ganglion neurons (SGN) carry sound information from cochlear hair cells to the brain. After noise, antibiotic or toxic insult to the cochlea, damage to SGN and/or hair cells causes hearing impairment. Damage ranges from fiber and synapse degeneration to dysfunction and loss of cells. New interventions to regenerate peripheral nerve fibers could help reestablish transfer of auditory information from surviving or regenerated hair cells or improve results from cochlear implants, but the biochemical mechanisms to target are largely unknown. Presently, no drugs exist that are FDA approved to stimulate the regeneration of SGN nerve fibers. We designed an original phenotypic assay to screen 440 compounds of the NIH Clinical Collection directly on dissociated mouse spiral ganglia. The assay detected one compound, cerivastatin, that increased the length of regenerating neurites. The effect, mimicked by other statins at different optimal concentrations, was blocked by geranylgeraniol. These results demonstrate the utility of screening small compound libraries on mixed cultures of dissociated primary ganglia. The success of this screen narrows down a moderately sized library to a single compound which can be elevated to in-depth in vivo studies and highlights a potential new molecular pathway for targeting of hearing loss drugs.