bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined use of dexmedetomidine and nalbuphine in laparoscopic radical gastrectomy for gastric cancer
Authors: Zhao Guo-Guang , Lou Chao , Gao Rong-Lei , Lei Fu-Xing , Zhao Jing 
Published: July 2024

BACKGROUND
Radical laparoscopic gastrectomy is an important treatment modality for gastric cancer. Surgery requires general anesthesia, and patients are susceptible to the effects of anesthetic drugs and carbon dioxide insufflation during the procedure, leading to inflammation or severe pain, which can affect patient outcome.
AIM
To explore the efficacy of combining dexmedetomidine (DEX) with nalbuphine in patients underwent laparoscopic radical gastrectomy for gastric cancer.
METHODS
Patients scheduled to undergo laparoscopic radical gastrectomy were selected and randomly assigned to A or B group. In A group, patients received an intravenous injection of nalbuphine 0.2 mg/kg + DEX 0.4 μg/kg 10 min before the end of surgery; in B group, patients received only an intravenous injection of nalbuphine. The trends in hemodynamic parameter fluctuations, awakening quality during the recovery period, serum inflammatory markers, agitation scores, cough severity, incidence, and duration of postoperative delirium (POD) were compared.
RESULTS
The mean arterial pressure and heart rate in the A group were more stable (P < 0.05). The A group had a lower average awakening time, extubation time, and agitation scores during recovery than the B group. Agitation control in the A group was more effective at different time points (P < 0.05). Patients in the A group had lower serum interleukin (IL)-6, tumour necrosis factor alpha, and IL-10 levels at 1 h after surgery than the B group. The incidence of coughing and duration of POD were lower and shorter in the A group than in the B group. Adverse reactions caused by the two anesthesia methods were less frequent in the A group than in the B group (P < 0.05).
CONCLUSION
The use of DEX and nalbuphine in patients undergoing laparoscopic radical gastrectomy for gastric cancer help reducing the inflammatory response, cough severity, and agitation and helps maintain hemodynamic stability.
Multi-Omics analysis elucidates tumor microenvironment and intratumor microbes of angiogenesis subtypes in colon cancer
Authors: Yang Yi , Qiu Yu-Ting , Li Wen-Kun , Cui Zi-Lu , Teng Shuo , Wang Ya-Dan , Wu Jing 
Published: July 2024

BACKGROUND
Angiogenesis plays an important role in colon cancer (CC) progression.
AIM
To investigate the tumor microenvironment (TME) and intratumor microbes of angiogenesis subtypes (AGSs) and explore potential targets for antiangiogenic therapy in CC.
METHODS
The data were obtained from The Cancer Genome Atlas database and Gene Expression Omnibus database. K-means clustering was used to construct the AGSs. The prognostic model was constructed based on the differential genes between two subtypes. Single-cell analysis was used to analyze the expression level of SLC2A3 on different cells in CC, which was validated by immunofluorescence. Its biological functions were further explored in HUVECs.
RESULTS
CC samples were grouped into two AGSs (AGS-A and AGS-B) groups and patients in the AGS-B group had poor prognosis. Further analysis revealed that the AGS-B group had high infiltration of TME immune cells, but also exhibited high immune escape. The intratumor microbes were also different between the two subtypes. A convenient 6-gene angiogenesis-related signature (ARS), was established to identify AGSs and predict the prognosis in CC patients. SLC2A3 was selected as the representative gene of ARS, which was higher expressed in endothelial cells and promoted the migration of HUVECs.
CONCLUSION
Our study identified two AGSs with distinct prognoses, TME, and intratumor microbial compositions, which could provide potential explanations for the impact on the prognosis of CC. The reliable ARS model was further constructed, which could guide the personalized treatment. The SLC2A3 might be a potential target for antiangiogenic therapy.
N6-methyladenosine modification of hypoxia-inducible factor-1α regulates Helicobacter pylori-associated gastric cancer via the PI3K/AKT pathway
Authors: An Tong-Yan , Hu Quan-Man , Ni Peng , Hua Yan-Qiao , Wang Di , Duan Guang-Cai , Chen Shuai-Yin , Jia Bin 
Published: July 2024

BACKGROUND
Helicobacter pylori (H. pylori ) colonizes the human gastric mucosa and is implicated in the development of gastric cancer (GC). The tumor microenvironment is characterized by hypoxia, where hypoxia-inducible factor-1α (HIF-1α) plays a key role as a transcription factor, but the mechanisms underlying H. pylori -induced HIF-1α expression and carcinogenesis remain unclear.
AIM
To explore the underlying mechanism of H. pylori -induced HIF-1α expression in promoting the malignant biological behavior of gastric epithelial cells (GES-1).
METHODS
The study was conducted with human GES-1 cells in vitro . Relative protein levels of methyltransferase-like protein 14 (METTL14), HIF-1α, main proteins of the PI3K/AKT pathway, epithelial-mesenchymal transition (EMT) biomarkers, and invasion indicators were detected by Western blot. Relative mRNA levels of METTL14 and HIF-1α were detected by quantitative reverse transcription-polymerase chain reaction. mRNA stability was evaluated using actinomycin D, and the interaction between METTL14 and HIF-1α was confirmed by immunofluorescence staining. Cell proliferation and migration were evaluated by cell counting kit-8 assay and wound healing assay, respectively.
RESULTS
H. pylori promoted HIF-1α expression and activated the PI3K/AKT pathway. Notably, METTL14 was downregulated in H. pylori -infected gastric mucosal epithelial cells and positively regulated HIF-1α expression. Functional experiments showed that the overexpression of HIF-1α or knockdown of METTL14 enhanced the activity of the PI3K/AKT pathway, thereby driving a series of malignant transformation, such as EMT and cell proliferation, migration, and invasion. By contrast, the knockdown of HIF-1α or overexpression of METTL14 had an opposite effect.
CONCLUSION
H. pylori- induced underexpression of METTL14 promotes the translation of HIF-1α and accelerates tumor progression by activating the PI3K/AKT pathway. These results provide novel insights into the carcinogenesis of GC.
Clinical benefits of transarterial chemoembolization combined with tyrosine kinase and immune checkpoint inhibitors for unresectable hepatocellular carcinoma
Authors: Han Feng , Wang Xiao-Han , Xu Chen-Zhou 
Published: July 2024

BACKGROUND
Combination therapy has emerged as the focus of research for unresectable hepatocellular carcinoma (HCC). In recent years, several studies have explored the clinical efficacy and safety of the combination therapies of transarterial chemoembolization (TACE) with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs).
AIM
To conduct an updated meta-analysis verifying the clinical benefits and adverse effects of the triple combination therapy for unresectable HCC.
METHODS
All eligible cohort, non-randomized controlled, and randomized controlled trial studies from the PubMed, Web of Science, Embase, Cochrane Library, and MedLine databases up to March 20, 2024 were screened for the present meta-analysis. The study endpoints included complete response (CR), objective response rate (ORR), disease control rate (DCR), overall survival (OS), progression-free survival (PFS), and adverse events (AEs). Stata 16/18 software was used for this meta-analysis, and a P value of <0.05 was considered statistically significant.
RESULTS
A total of 29 studies with 1754 patients were included. Among the patients who received the TACE therapy with TKIs and ICIs, the tumor response results revealed a pooled CR, ORR, and DCR of 14% [95%CI (0.11–0.18)], 61% [95%CI (0.55–0.66)], and 85% [95%CI (0.83–0.87)], respectively. In terms of the survival outcomes, the pooled median PFS and OS were 10.25 months [95%CI (9.31–11.18)] and 20.47 months [95%CI (18.98–21.97)], respectively. The pooled prevalence of all-grade AEs during the triple treatment was 90% [95%CI (0.84–0.94)] and that of grade ≥ 3 AEs was 32% [95%CI (0.24–0.42)].
CONCLUSION
The combination therapy of TACE, TKIs, and ICIs exhibits great clinical benefits for unresectable HCC in terms of tumor responses and survival outcomes without increasing the risk of severe AEs.
Research trends and hotspots in the immune microenvironment related to hepatocellular carcinoma: A bibliometric and visualization study
Authors: Zhang Da-Ya , Bai Fei-Hu 
Published: July 2024

BACKGROUND
The immune microenvironment (IME) in hepatocellular carcinoma (HCC) plays a pivotal role in determining patient outcomes and responses to treatment. This area is witnessing rapid growth in research interest. However, there is a lack of comprehensive bibliometric analyses that dissect trends and potential focal points in this field.
AIM
To explore the evolution of research on the IME in HCC from January 1, 2004, to December 31, 2023, using bibliometric methodologies.
METHODS
English articles and reviews concerning the IME of HCC were retrieved from the Web of Science Core Collection with a search date of December 31, 2023. The R package Bibliometrix was employed to compute basic bibliometric characteristics, illustrate collaborations among countries and authors, and create a three-field diagram illustrating the connections between authors, affiliations, and keywords. Analyses of country and institutional co-authorship, as well as keyword co-occurrence, were conducted using VOSviewer. Additionally, CiteSpace was utilized for the cite burst analysis of keywords and cited literature.
RESULTS
The study encompassed 3125 documents in the research areas related to HCC of IME, revealing a substantial and continuous increase in the annual publication trend over time. China and Fudan University emerged as leading contributors, with 2103 and 165 publications, respectively. Frontiers in immunology was the most prolific journal in this domain. Among the top ten researchers in the field, eight are based in China. Key research terms identified include tumour microenvironment, expression, immunotherapy, and prognosis.
CONCLUSION
The relationship between HCC and IME is receiving increasing attention, and related research is in a highly developed stage. Key focus areas, including IME and immune checkpoint inhibitors, immunotherapy are poised to be central to future research endeavors, offering promising pathways for further exploration.
Rare infiltrative primary hepatic angiosarcoma: A case report and review of literature
Authors: Lin Xiao-Jing , Luo Hong-Chang 
Published: July 2024

BACKGROUND
The most primary sites of angiosarcoma are the skin, breast gland, and soft tissues. Primary hepatic angiosarcoma (PHA) is a rare malignant tumor of mesothelial tissue originating from the liver. PHA often presents with multiple intrahepatic foci or metastasis at the time of presentation due to its nonspecific clinical presentation and highly aggressive nature. There are no established or effective treatment guidelines for PHA, so early detection and early treatment are of great value for patient survival. Unfortunately, there is a paucity of literature on the imaging features of PHA, making the diagnosis and treatment of this disease a considerable challenge.
CASE SUMMARY
In this case report, we present a 59-year-old man who initially presented with abdominal pain and radiating pain in the right shoulder. Magnetic resonance imaging and positron emission tomography-computed tomography revealed multiple intrahepatic nodules that needed to be differentiated from tumors of vascular epithelial origin and tumors with progressive enhancement features, and signs of tumor metastasis were assessed. The patient was then subjected to contrast-enhanced ultrasonography (CEUS) to further clarify the extent of tumor infiltration and the state of microcirculatory perfusion. The manifestations observed on CEUS were similar to the classical characteristic presentation of hepatocellular carcinoma, called "quick wash-in and quick wash-out". In addition, CEUS showed that the lesion exhibited gradual infiltration and growth along the liver pedicle structures with no invading blood vessels. Finally, based on pathological and immunohistochemical tests and the above imaging manifestations, it was confirmed that the patient had infiltrating PHA, which is a rare pathological type of PHA. The patient underwent transcatheter arterial chemoembolization and chemotherapy. Four months after the onset of symptoms, the follow-up radiological examination revealed poor treatment efficacy and rapid deterioration.
CONCLUSION
This case report complements the imaging modalities of a rare infiltrative PHA, in which CEUS and quantitative analysis are found to offer substantial advantages in characterizing the microcirculatory perfusion of the lesion, providing clinicians with diagnostic information at the earliest opportunity to make a diagnosis and develop a treatment strategy to prolong the patient survival.
Teachers’ Knowledge And Practice Of Accommodation For Pupils With Visual Impairment In Basic Schools In Owerri North Local Government, Imo, Nigeria
Authors: James Ebrikure Olayi , Uche Opara , J E Ewa , Felicia A Unimke 
Published: July 2024

This study investigated teachers’ knowledge and practice of accommodation for pupils with visual impairment in basic schools in Owerri North Local Government. The study was carried out to examine the level of basic school teacher's knowledge accommodation strategies fmmor pupils with visual impairment and to ascertain the extent of practice accommodation strategies for pupils with visual impairment. Respondents were 80 basic school teachers selected through convenience sampling. Questionnaire on Accommodation Strategies for Pupils with Visual Impairment (QASPVI) developed and validated by the researcher was used to collect data for the study. Data collected were analyzed using frequency count, percentage, mean and standard deviation. Results show low level of knowledge of accommodation strategies among the respondents as 61.1% of the respondents were not aware of accommodation strategies for persons with visual impairment while 38.9%were aware. It was also found that the level of practice of accommodation strategies for pupils with visual impairment among the respondents was
very low as shown by the weighted average (X =1.38; SD= 0.484). The need for regular in-service workshop for basic school teachers on accommodation strategies for pupils with visual impairment in Basic Schools in Owerri North Local Government Area and provision of necessary facility and equipment such as resource room, Braille machine,
large print, audiotape, etc. which will enable teachers accommodate pupils with visual impairment in classroom instruction were recommended.
Moral Value, Peer Influence And Tendencies To Cybercrime Involvement Among Undergraduates In Public Universities In Cross River State
Authors: Uchenna Egodi Ajake , Goodness Uka Kalu , Samson Chidubem Ugwu 
Published: July 2024

The study investigated moral value, peer influence and tendencies to cybercrime involvement among undergraduates in Public Universities, Cross River State, Nigeria. The research questions formulated to guide this study were two and two hypotheses were also formulated. Survey research design was adopted for the study. The population of the study comprised all the 400 level students in the two conventional public universities in Cross River State which include University of Calabar and University of Cross River State with the total of 7020 students in 2021/2022 academic session. A sample of 400 undergraduates were randomly selected for the study through stratified sampling technique. The instrument for data collection was a well-structured questionnaire titled; “Moral Value, Peer Influence and Tendencies to Cybercrime Involvement Questionnaire” (MVPITCIQ). Simple Linear Regression was the statistical technique employed to test the hypotheses at .05 level of significance. Findings revealed that, moral value, peer influence significantly predict tendencies to cybercrime involvement among undergraduates in Public Universities in Cross River State. Based on the conclusion drawn, it was recommended that parents, teachers and significant others should inculcate positive morals to students. Also, moral values education should be taught in our Universities so as to curb the problems of cybercrimes. This means that moral value and peer influence can predict students’ propensities to minimise indulgence in cybercrime.
ХIХ АСР ИККИНЧИ ЯРМИ ХХ АСРЛАРДА САМАРҚАНД ВИЛОЯТИ КАТТАҚЎРҒОН БЎЛИМИ АҲОЛИСИНИНГ ТОИФАЛАРИ ВА МИЛЛАТЛАРИ ТАРКИБИ
Authors: Холхужаева Юлдуз 
Published: July 2024

Зарафшон музофоти ва унинг Каттақўрғон бўлими аҳолисининг этник таркиби ва сони тўғрисида бирламчи ёзма манбаларда, шунингдек, махсус тарихий адабиётларда келтирилган маълумотларни тадқиқ ва таҳлил этиш, уларни умумлаштириш аҳолининг сони ва этник таркиби хусусиятларини аниқлаш вазифалари қўйилган. Каттақўрғон бўлими аҳолисининг тоифалар ва миллатлар бўйича сони ҳақида бир қанча маълумотлар келтирилган.
GLOBALLASHUV SHAROITIDA - YOSHLAR MA’NAVIYATIGA TA’SIR QILUVCHI OMILLAR
Authors: G‘ulomov Obid 
Published: July 2024

Globallashuv sharoitida voqea-hodisalarni tо‘g‘ri talqin qila olish, har bir voqelikning yoshlarning ma’naviyatiga ta’sir qilish omillarni o’rganish asosida tahlildan о‘tkazish ulkan ahamiyat kasb etadi. Buning uchun esa milliy g‘oya va mafkuramiz mustahkam bо‘lmog‘i lozim, yoshlar ongi va tafakkuriga ta’sir qiluvchi yot g‘oyalar ta’siriga berilib qolmaslikni ta’minlashi bilan birga ularga munosib javob qaytarish kо‘nikmasini ham shakllantiradi, milliy qadriyatlarimizni hurmat qilishga va uni asrab- avaylash muhim ahamiyat kasb etilishi muhim ahamiyat kasb etadi.
تعليم القصة باستخدام الوسيلة السمعية البصرية
Authors: Jailani  
Published: July 2024

Learning a language can be effectively and effciently last if is supported by the use of appropriate methode varied and interesting. In the Arabic language learning for esample the use of story as learning method in hand to increase the interest and skills of students in learning Arabic, in which students are required to be able to directly communicate both verbally and non verbally by using the Arabic language. This article aims at discusing story and its use in teaching and learning Arabic
Zootherapy and ethnozoological studies of Medicinal animals and their products used by the tribal communities in Goa
Authors: Gaonkar Harshada , Gaonkar Akshita , Velip Anjali , Rajender Rao Kulkarni 
Published: July 2024

Traditional medicine is also known by several other terms such as alternative or complementary or folk medicine'. It includes the sum of the total knowledge, health practices approaches and beliefs incorporating plants, animals, minerals, medicines, spiritual therapies, yoga and physical exercises used by different cultures for generations to prevent, diagnose and treat physical and mental illness or to maintain health in a holistic sense. Documentation and evaluation of this indigenous remedial knowledge is essential for the development of the pharmaceutical industry. Some researchers have made an attempt to study and document the usage of medicinal animals by traditional healers. However, there is no scientific documentation on the use of medicinal animals in the treatment for various diseases in the primary health care system by the tribal communities in Goa. Present study is aimed to document different zoo therapeutic medicinal animals and their utilization in the traditional health care system among the Gawda and Dhangar communities, the native tribes of Goa.
A recepção de recomendações quanto ao trabalho decente nas decisões judiciais referentes ao trabalho escravo no brasil: uma hipótese negada
Authors: Santos Baruana Calado dos 
Published: July 2024

Apresentam-se alguns dos resultados de pesquisa que buscou verificar a influência das recomendações sobre trabalho decente, veiculadas pelo Relatório de Desenvolvimento Humano de 2015, do PNUD, na fundamentação das decisões judiciais brasileiras relativas ao trabalho escravo. A partir da sociologia histórica processual, a análise hermenêutica histórica das decisões revelou que suas fundamentações não acolhem tais recomendações. As decisões judiciais ainda se ocupam em definir o conceito de trabalho escravo e demonstram pouca eficácia na coibição do crime ao estipularem baixo valor indenizatório para os que se utilizam de mão de obra escravizada. Ao destacar a importância das estratégias sugeridas pelo PNUD, busca-se indicar caminhos para sua aplicabilidade como comandos de otimização na prática judicial brasileira no combate ao trabalho escravo.
Application of The Support Vector Machine Algorithm for Timely Student Graduation Prediction Based on Streamlit Web at The Faculty of Informatics Engineering Nurul Jadid University
Authors: Yati Yati , Ainol Yaqin Moh , Yusrotun Nadhiroh Anis 
Published: July 2024

Universities must provide good education so that they can produce good graduates.There are many factors that influence student graduation rates, one of the problems faced by an educational institution, especially at universities, whether state or private, is finding predictions of student graduation rates on time.One of the technological advances currently available is a system that can predict whether students will graduate on time or not. One of the machine planning algorithms that can be used is the Support Vector Machine.The results of this research were carried out by predicting the on-time graduation rate of students at Nurul Jadid University, Faculty of Engineering, Informatics Study Program. By using the Support Vector Machine method, this research used testing data of 20% of the data from 612 student data with the same 7 attributes. The data obtained 123 data which resulted in 72 student data being on time, 45 student data being late, 4 student data being correct. time and 2 students' data was late. From the results, the accuracy of the training data was 94%, while the results of the accuracy of the testing data received a score of 95%. And based on the validity test of the Support Vector Machine algorithm, the presentation results obtained were Accuracy levels of 96%, Recall 98%, and Precision 94% from 123 testing data. Next, the model is deployed using Streamlit. Streamlit is an open source Python-based framework designed to help developers build interactive web-based programs in the fields of data science and machine learning. The accuracy rate is very good, this shows that SVM can be applied to predict student graduation rates.
Hemoperitoneo secundario a tumor maligno de la vaina del nervio periférico en hígado
Authors: Chávez-Sánchez Siomara Aransuzú , Bellido-Caparó Álvaro , Gallegos-Serruto Guido Saúl , Vásquez Morales Víctor Manuel , Bravo-Taxa Mercedes Del Pilar , García-Encinas Carlos Aurelio 
Published: July 2024

Los tumores malignos de la vaina del nervio periférico se asocian con frecuencia a neurofibromatosis tipo 1. Se localizan habitualmente en las extremidades o en la zona axial. Su ubicación visceral es muy rara y el origen hepático infrecuente. Suelen ser agresivos con pobre repuesta a la quimioterapia y radioterapia, por lo que el manejo quirúrgico es la mejor opción de tratamiento. Presentamos el caso de un joven con neurofibromatosis tipo 1, quien cursó con hemoperitoneo como complicación de un tumor maligno de la vaina del nervio periférico ubicado en el hígado.