bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous Veno-Venous Hemofiltration using a Phosphate-Containing Replacement Fluid in the Setting of Regional Citrate Anticoagulation
Authors: Morabito Santo , Pistolesi Valentina , Tritapepe Luigi , Vitaliano Elio , Zeppilli Laura , Polistena Francesca , Fiaccadori Enrico , Pierucci Alessandro 
Published: January 2015

Purpose The need for prolonged anticoagulation and the occurrence of hypophosphatemia are well known drawbacks of continuous renal replacement therapies (CRRT). The aim was to evaluate the effects on acid-base status and serum phosphate of a regional citrate anticoagulation (RCA) protocol for continuous veno-venous hemofiltration (CVVH) combining the use of citrate with a phosphate-containing replacement fluid. Methods In a small cohort of heart surgery patients undergoing CRRT for acute kidney injury, we adopted an RCA-CVVH protocol based on a commercially available citrate solution (18 mmol/l) combined with a recently introduced phosphate-containing replacement fluid (HCO3− 30 mmol/l, phosphate 1.2), aimed at preventing phosphate depletion. Results In 10 high bleeding-risk patients, the RCA-CVVH protocol provided an adequate circuit lifetime (46.8 ± 30.3 h) despite the adoption of a low citrate dose and a higher than usual target circuit Ca2+ (≤0.5 mmol/l). Acid-base status was adequately maintained without the need for additional interventions on RCA-CVVH parameters and without indirect sign of citrate accumulation [(pH 7.43 (7.41-7.47), bicarbonate 24.4 mmol/l (23.2-25.6), BE 0 (-1.5 to 1.1), calcium ratio 1.97 (1.82-2.01); median (IQR)]. Serum phosphate was steadily maintained in a narrow range throughout RCA-CVVH days [1.1 mmol/l (0.9-1.4)]. A low amount of phosphorus supplementation (0.9 ± 2 g/day) was required in only 30% of patients. Conclusions Although needing further evaluation, the proposed RCA-CVVH protocol ensured a safe and effective RCA without electrolyte and/or acid-base derangements. CRRT-induced hypophosphatemia was prevented in most of the patients by the adoption of a phosphate-containing replacement solution, minimizing phosphate supplementation needs.
The Accuracy of a Continuous Volumetric Balancing System in Pediatric Continuous Renal Replacement Therapy
Authors: Hanudel Mark R. , Salusky Isidro B. , Zaritsky Joshua J. 
Published: January 2015

Background In pediatric continuous renal replacement therapy (CRRT) patients, accurate ultrafiltration (UF) measurement is essential, as both over- and under-UF may result in suboptimal outcomes. Traditionally, CRRT has relied on scale-based UF measurements; however, the recent development of a continuous volumetric balancing system has allowed for the advent of scale-less CRRT. Methods To assess the accuracy of the volumetric balancing system, we designed a continuously measuring digital scale, which accounted for dialysate use and collected effluent, allowing us to independently measure UF volume and compare it with the machine reported UF volume. Results In four low weight (6.9-16.7 kg) pediatric CRRT patients, we measured the UF volume over 20 separate runs, comprising a total of 318 hours. Over this time, the total measured UF volume was 50,550 mL ± 296 mL, whereas the total reported UF volume was 50,733 mL, a difference of 183 mL ± 296 mL (0.6 ± 0.9 ml/h), or 0.4 ± 0.6%. For each patient, over 48-112 hours per patient, the differences between the total measured and total reported UF volumes ranged from -7.8 ± 1.7 ml/h to +9.7 ± 1.8 ml/h, or -6.0 ± 1.3% to +5.4 ± 1.0%. Conclusions In low-weight, pediatric CRRT patients, the scale-less continuous volumetric balancing system delivers accurate ultrafiltration.
Comparative Effect of different Polymerization Techniques on Residual Monomer and Hardness Properties of PMMA-based Denture Resins
Authors: Ayaz Elif Aydogan , Durkan Rukiye , Koroglu Ayşegul , Bagis Bora 
Published: January 2015

Purpose The aim of this study was to compare the residual monomer and microhardness of poly(methyl methacrylate) (PMMA)–based denture resins processed by using autoclave and conventional water bath techniques. Methods To determine the amount of residual methyl methacrylate (MMA) monomer, disk-shaped specimens (n=5) were prepared from 3 different acrylic resins (Meliodent, Paladent and Qc-20). Control groups were polymerized in water bath for 30 minutes at 100°C. The study groups were prepared in an autoclave device for 60°C/30 min followed 130°C/10 min and the other group for 60°C/30 min followed by 130°C/20 min. According to standard calibration curves, ultraviolet spectrophotometry at 230 nm was used to determine the residual monomer. For the Vickers hardness measurements, disk-shaped specimens (n=5) were prepared for each test group. Hardness measurements were performed with a Vickers hardness tester under a 4.91-N press load for a 30 seconds, after immersion in distilled water at 37°C for 48 hours. The data were analyzed by ANOVA and Tukey HSD test (p<0.05). Results Autoclave polymerization produced a significant decrease in the amount of residual monomers for all resin groups (p<0.05). This procedure also showed a significant increase in hardness for all resin groups (p<0.05). For the 3 resin groups, no significant differences were found between autoclave polymerization for 10 minutes and for 20 minutes (p>0.05). Conclusions The autoclave polymerization technique exhibited significantly lower residual monomer content and greater hardness than conventional heat polymerization.
Melatonin and the Charlson Comorbidity Index (CCI): The Treviso Longeva (Trelong) Study
Authors: Gallucci Maurizio , Flores-Obando Rafael , Mazzuco Stefano , Ongaro Fausta , Di Giorgi Enrico , Boldrini Paolo , Durante Elisabetta , Frigato Andrea , Albani Diego , Forloni Gianluigi , Zanardo Andrea , Siculi Marinella , Caberlotto Livio , Taioli Emanuela 
Published: January 2015

Introduction It has been reported that elderly subjects have a compromised ability to produce melatonin nightly, and that reduced melatonin levels may be a risk factor for cancer. The purpose of this study was to evaluate the relationship between melatonin levels and chronic diseases in a cohort of elderly subjects using the Charlson comorbidity index (CCI). Design We performed a secondary data analysis of a longitudinal study of a representative, age-stratified, sample population. Setting The Treviso Longeva (Trelong) study, in Treviso, Italy. Participants A total of 114 men and 146 women, aged 77 years and older, still alive after 7 years of follow-up. Measurements As an estimation of serum melatonin secretion levels, urinary 6-sulfatoxymelatonin (aMT6s) was assayed in the urine of 260 elderly subjects using an enzyme-linked immunosorbent assay (ELISA) kit (product 01-EK-M6S, ALPCO Immunoassays, Windham, NH). All aMT6s levels were creatinine standardized ([aMT6s]/[creatinine]), and the CCI was calculated. Results The melatonin levels decreased with aging despite not reaching statistical significance, and the decrease was more evident in males than in females (40.5 ng vs 47.0 ng aMT6s/mg creatinine, ns). Melatonin levels were significantly lower in patients reporting insomnia (p=0.05). The CCI score was inversely correlated with the levels of melatonin (p=0.03). Melatonin levels of subjects affected by CCI pathologies were significantly lower than those of healthy subjects (p=0.03) and of subjects suffering from diseases not included in the CCI and, therefore, less severe (p=0.03). Conclusion Melatonin appears to be a marker of disease state and severity, as well as of sleep disorders, in the elderly. These early findings would confirm the protective role of melatonin against several chronic diseases. The benefits of this agent as a possible medication should be more thoroughly clinically tested.
Serum ANGPTL2 Levels Reflect Clinical Features of Breast Cancer Patients: Implications for the Pathogenesis of Breast Cancer Metastasis
Authors: Endo Motoyoshi , Yamamoto Yutaka , Nakano Masahiro , Masuda Tetsuro , Odagiri Haruki , Horiguchi Haruki , Miyata Keishi , Kadomatsu Tsuyoshi , Motokawa Ikuyo , Okada Seiji , Iwase Hirotaka , Oike Yuichi 
Published: January 2015

Introduction Breast cancer is a leading cause of cancer-related death in women worldwide, and its metastasis is a major cause of disease mortality. Therefore, identification of the mechanisms underlying breast cancer metastasis is crucial for the development of therapeutic and diagnostic strategies. Our recent study of immunodeficient female mice transplanted with MDA-MB231 breast cancer cells demonstrated that tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) accelerates metastasis through both increasing tumor cell migration in an autocrine/paracrine manner, and enhancing tumor angiogenesis. To determine whether ANGPTL2 contributes to its clinical pathogenesis, we asked whether serum ANGPTL2 levels reflect the clinical features of breast cancer progression. Methods We monitored the levels of secreted ANGPTL2 in supernatants of cultured proliferating MDA-MB231 cells. We also determined whether the circulating ANGPTL2 levels were positively correlated with cancer progression in an in vivo breast cancer xenograft model using MDA-MB231 cells. Finally, we investigated whether serum ANGPTL2 levels were associated with clinical features in breast cancer patients. Results Both in vitro and in vivo experiments showed that the levels of ANGPTL2 secreted from breast cancer cells increased with cell proliferation and cancer progression. Serum ANGPTL2 levels in patients with metastatic breast cancer were significantly higher than those in healthy subjects or in patients with ductal carcinoma in situ or non-metastatic invasive ductal carcinoma. Serum ANGPTL2 levels in patients negative for estrogen receptors and progesterone receptors, particularly triple-negative cases, reflected histological grades. Conclusions These findings suggest that serum ANGPTL2 levels in breast cancer patients could represent a potential marker of breast cancer metastasis.
Superficialization of Basilic Vein: Last Chance for a Native Arteriovenous Fistula in Hemodialysis Patients
Authors: Onaran M. , Erer D. , Şen I. , Elnur E.E. , Iriz E. , Sert Ş. 
Published: January 2015

Background Although the best type of vascular access for chronic hemodialysis patients is a native arteriovenous fistula, in an increasing number of patients all the superficial veins have been used and only the placement of vascular grafts or permanent catheters is left. Superficialization of the basilic vein is a possible alternative. Materials and Methods In 49 chronic hemodialysis patients who had no possibilities to have a native arteriovenous fistula created, we performed a basilic vein- brachial artery fistula in the arm. During the same operation the basilic vein was then superficialized for easier access for hemodialysis. Results Mean follow-up was 22.36±15.56 months. Forty-eight patients are still undergoing hemodialysis with their superficialized basilic vein native A-V fistula without any complications. Only one fistula was thrombosed just after the procedure because of poor vessel quality. Conclusion For hemodialysis patients who have no suitable superficial veins at the wrist or elbow, performing a basilic vein - brachial artery fistula and superficializing the vein to the subcutaneous tissue is an acceptable choice before deciding to use more complicated procedures like vascular grafts.
A program for obese youth at-risk for diabetes in Qatar
Authors: Selmi Sahar , Daghash Ghadeer , Mathis Sharoud , Nahas Katie , Wilbur Kerry 
Published: January 2015

Background: Obesity is an international public health problem well documented in Qatar among children and adolescents and contributes to diabetes, a disease already highly prevalent in the country. We describe an intervention program developed for obese youth conducted by the Qatar Diabetes Association (QDA). Methods: The QDA conducts a 3-day structured program for obese youth at-risk for developing diabetes which includes physical activities, games and workshops aimed to increase awareness and guide improved diet, activity and related lifestyle choices. Using motivational interviewing techniques, obese youth develop action plans to modify diet and exercise which were shared with parents to promote collaboration and support. Results: In 2011, one girls' camp (n = 15, mean age 12 years) and one boys' camp (n = 17, mean age 13 years) were held. All participants were considered obese: girls mean BMI = 31 kg/m2 (standard deviation (SD) 4.2) and boys mean BMI 35 kg/m2 (SD = 4.7). Youth reported fast food consumption at least twice a week by 6 (40 %) of girls and 10 (59 %) of boys and there was low self-declared frequency of daily physical activity (1 girl and 5 boys). Many stated their weight made their life worse due to fatigue, poor agility, or difficulty finding clothes. When individualized coaching was proposed, 87 % and 100 % of girls and boys felt ready to devise an action plan for improved health. Conclusion: The new national preventative healthcare mandate could facilitate modification and expansion of these QDA educational and behavioural intervention programs as part of the wider strategy to combat obesity in Qatar.
Europese bankenresolutie (SRM). Institutionele perspectieven
Authors: ter Kuile G. 
Published: January 2015

Europese bankenresolutie (SRM). Institutionele perspectieven
‘Too Big to Fail’ banken waren een kostbaar probleem tijdens de crisis die in 2007 uitbrak. Een speciaal soort afwikkelingsrecht voor banken – ‘resolutierecht’ – bleek nodig om belastingbetalers voortaan te sparen. Met het oprichten van een gemeenschappelijk resolutiemechanisme stonden de EU-lidstaten voor een nieuwe uitdaging. Gemeenschappelijke regels, procedures en instellingen werden bij richtlijn en verordening geïntroduceerd, terwijl het resolutiefonds met een intergouvernementele overeenkomst werd bestendigd. Dit artikel bespreekt resolutie als concept, de verdragsgrondslag van de regelingen, de Single Resolution Board als agentschap en de Meroni-discussie, gedeelde bevoegdheden en significantiecriterium, interne en externe governance, het Resolutiefonds en ‘mutualisatie’, en rechtsbescherming. De hoop is uiteraard dat met een effectief Europees bankentoezicht het daadwerkelijk overgaan tot resolutie niet nodig is. Maar de voorbereiding op eventuele resoluties blijft vereist.Verordening (EU) nr. 806/2014 van het Europees Parlement en de Raad van 15 juli 2014 tot vaststelling van eenvormige regels en een eenvormige procedure voor de afwikkeling van kredietinstellingen en bepaalde beleggingsondernemingen in het kader van een gemeenschappelijk afwikkelingsmechanisme en een gemeenschappelijk afwikkelingsfonds en tot wijziging van Verordening (EU) nr. 1093/2010 (SRM-Verordening of SRMR).Richtlijn 2014/59/EU van het Europees Parlement en de Raad van 15 mei 2014 betreffende de totstandbrenging van een kader voor het herstel en de afwikkeling van kredietinstellingen en beleggingsondernemingen en tot wijziging van Richtlijn 82/891/EEG van de Raad en de Richtlijnen 2001/24/EG, 2002/47/EG, 2004/25/EG, 2005/56/EG, 2007/36/EG, 2011/35/EU, 2012/30/EU en 2013/36/EU en de Verordeningen (EU) nr. 1093/2010 en (EU) nr. 648/2012, van het Europees Parlement en de Raad (BRRD-richtlijn of BRRD).Overeenkomst betreffende de overdracht en mutualisatie van de bijdragen aan het gemeenschappelijk afwikkelingsfonds, Brussel, 21 mei 2014, (8457/14), Trb. 2014, 146
Non bis in idem in Europa: de zaken Spasic en M.
Authors: van Hattum W.F. 
Published: January 2015

Non bis in idem in Europa: de zaken Spasic en M.
Binnen Schengen en de EU geldt de regel dat iemand die onherroepelijk is berecht niet nog eens mag worden vervolgd of gestraft wegens hetzelfde feit (non bis in idem). Geldt deze bescherming ook wanneer de straf wel definitief is geworden maar nog niet ten uitvoer is gelegd? Artikel 54 van de Schengenuitvoeringsovereenkomst is hierover duidelijk: het stelt tenuitvoerlegging als voorwaarde voor toepassing van de waarborg tegen tweede vervolging of bestraffing. Artikel 50 Handvest stelt deze voorwaarde echter niet. In de zaak Spasic beoordeelt het Hof van Justitie – voor het eerst – de verhouding tussen beide non bis in idem-bepalingen.In de zaak M. is de vraag aan de orde of een ‘buitenvervolgingstelling’ een tweede vervolging in een andere lidstaat belet. Het betreft een strafrechtelijke beslissing die nationaal een minder sterke non bis in idem-werking heeft dan een onherroepelijk eindvonnis. Deze bijdrage laat aan de hand van beide zaken zien hoe het Hof van Justitie de balans probeert te houden tussen vrijheid, veiligheid en recht enerzijds en het voorkomen en bestrijden van criminaliteit anderzijds.HvJ 27 mei 2014 (GK), zaak C-129/14 PPU, Spasic, prejudiciële spoedprocedure op verzoek Oberlandesgericht Nürnberg (Duitsland), ECLI:EU:C:2014:586, n.n.g. en HvJ 5 juni 2014, zaak C-398/12, M., prejudiciële procedure op verzoek Tribunale di Fermo (Italië), ECLI:EU:C:2014:1057, n.n.g.
Des Insolences au ministère de l’Éducation québécois… L’exil suisse de Frère Untel au miroir de sa correspondance
Authors: Hauser Claude 
Published: January 2015

Si un livre demeure emblématique du déclenchement de la Révolution tranquille au Québec, c’est bien celui de Jean-Paul Desbiens, publié en 1960 sous le titre Les insolences du frère Untel. On connaît bien sa genèse, son contenu et ses répercussions retentissantes dans la société québécoise, mais on connaît moins bien le destin mouvementé de son auteur, exilé à Rome puis à Fribourg par sa hiérarchie avant de revenir au Québec à l’été 1964, avec une charge au ministère de l’Éducation. Cet article se focalise sur le séjour de Jean-Paul Desbiens à Fribourg, en Suisse, de septembre 1962 à juillet 1964, durant lequel il va principalement se consacrer à la rédaction d’une thèse sur l’oeuvre de Jean Piaget. Quelle valeur prend ce séjour helvétique dans le parcours intellectuel de Jean-Paul Desbiens ? Comment vit-il cette expérience d’exil au quotidien ? S’intègre-t-il à son milieu de vie ? Quels sont ses réseaux de contact et d’amitié personnels ? Met-il en rapport ce qu’il observe de la vie helvétique avec l’évolution politique et sociale du Québec, qu’il suit à distance ? Cet article tente de répondre à ces questions, principalement à partir de l’abondante correspondance échangée entre Martin Blais et Jean-Paul Desbiens durant cette période fribourgeoise.
L’art dans les territoires de la petite histoire : les monographies paroissiales
(1854-1926) et la représentation d’un legs culturel
Authors: Miglioli Nathalie 
Published: January 2015

Cet article traite de la présence de discours sur les objets d’art (principalement le
décor peint et le décor sculpté de l’église) dans les monographies paroissiales publiées
entre 1854 et 1926. De prime abord, il explore la manière dont les auteurs articulent les
sources qui fondent l’histoire de la paroisse, c’est-à-dire comment les auteurs – des
prêtres historiens pour la plupart – accordent le document d’archives, le souvenir des
anciens et les observations qui leur sont propres afin d’écrire le récit historique. Ce
texte explique ensuite comment l’approche particulière des auteurs en ce qui concerne ces
sources crée une énonciation à plusieurs temporalités où l’objet d’art cristallise le
rapport de la communauté à son histoire. Ce rapport, que met en évidence le discours sur le
tableau d’un maître-autel ou sur l’avènement de nouvelles formes architecturales, relève
peut-être d’un projet où le discours sur les oeuvres d’art serait essentiel : la
transmission, au moyen de l’écriture, d’un legs culturel.
A precariedade do sistema prisional e a [T] responsabilidade do Estado brasileiro em face dos crimes de tortura praticados no cárcere à luz dos direitos humanos
Authors: Rangel Caio Mateus Caires , Bayer Diego Augusto 
Published: January 2015

O objetivo do presente trabalho é analisar a precariedade do sistema prisional brasileiro e latino-americano, demonstrando as ofensas aos acordos internacionais que foram ratificados no âmbito dos Direitos Humanos. Este artigo busca investigar as mazelas do falido sistema prisional brasileiro, que dá ensejo à prática frequente de torturas no bojo das unidades carcerárias sob responsabilidade do Estado. Impende ainda evidenciar o papel da Organização dos Estados Americanos (OEA) quanto a denúncias da prática de tortura no sistema prisional brasileiro. A finalidade deste artigo versa justamente no sentido de demonstrar a falência do sistema prisional brasileiro e o descaso do Brasil em efetivar os compromissos assumidos na seara internacional de prevenir e punir a prática da tortura, o que pode levar a sanções internacionais. O direito de não ser torturado afigura-se no bojo das Constituições dos países como um direito fundamental, uma norma substancial que enfatiza a obrigação de se tratar pessoas encarceradas com dignidade e humanidade, independentemente dos recursos materiais do Estado em questão.
Vertical Integration and Inventory Management Efficiency *
Authors: Huang Jun , Xue Shuang , Hong Yun 
Published: January 2015

Abstract
This paper investigates the role of vertical integration in the inventory management of a supply chain. Taking Chinese listed companies from 2001 to 2010 as our sample, we find that vertically integrated firms have lower inventory holdings and volatility, indicating that vertical integration improves firms’ inventory management efficiency. Further analyses show that this effect is more pronounced for firms located in regions with a lower level of marketisation and for firms facing higher demand volatility and business growth. In addition, the more thoroughly firms have accomplished vertical integration, the more greatly vertical integration increases inventory management efficiency. Finally, we find that the positive impact of vertical integration on inventory management is more significant in industries with no overcapacity, for diversified firms, and during non-crisis periods.
Do Politically Connected Independent Directors Help Chinese Listed Private Firms Enter High-Barrier Industries?1
Authors: Du Xingqiang , Zeng Quan , Du Yingjie 
Published: January 2015

Abstract
On the basis of hand-collected data on political connections, this study examines the impact of politically connected independent directors on Chinese listed private firms’ entry into high-barrier industries. Our findings reveal the following: (1) politically connected independent directors are significantly positively associated with the likelihood and the degree of Chinese listed private firms’ entry into high-barrier industries; (2) in comparison with politically connected chief executive officers (CEOs), the influence of politically connected independent directors on Chinese listed private firms’ entry into high-barrier industries is more pronounced in terms of both statistical and economic significance; (3) the rank of politically connected independent directors is significantly positively associated with the likelihood and the degree of Chinese listed private firms’ entry into high-barrier industries; (4) both the central- and local-level political connections of independent directors significantly impact the likelihood and the degree of Chinese listed private firms’ entry into high-barrier industries; (5) the influence of politically connected independent directors on the likelihood and the degree of Chinese listed private firms’ entry into high-barrier industries is greater than that of politically connected CEOs regardless of the rank and the level of political connections. Our study extends the extant literature on political connections.