bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the concept of a responsive curriculum in teacher education from the perspective of students and teacher educators
Authors: van Bemmel Rieke , Zitter Ilya , de Bruijn Elly 
Published: August 2024

AbstractEconomic, social and environmental changes place high demands on teachers and teacher education. Consequently, teacher education is challenged to design curricula that respond to and anticipate changes. Curricula are value‐driven and even though part of these values might be constant, the relative importance of values and the values themselves may also be subject to change since society is changing rapidly. In vocational education, responsive curriculum development refers to balancing the needs of students, workplaces and society. Vocational education qualifies students for coping with unpredictable situations and complex problems in occupational practice. As in vocational education, teacher education also prepares students for unpredictability and complexity and thus, we adopt the concept of responsiveness from vocational education to explore teacher education. This study explores the concept of a responsive curriculum for teacher education using a qualitative approach. Interviews were conducted with the key actors, namely students and teacher educators, in the context of Dutch teacher education. An initial framework, consisting of three responsive dimensions and five designable elements, was used to guide the interviews and analyse the data. The data revealed 14 relevant themes to identify how a teacher education curriculum can be responsive to changes in society, to a variety of schools and to student diversity. The developed framework can serve as a conceptual frame to study the enactment of responsive curriculum designs. Also, it can support practitioners when designing responsive curricula.
Antiviral Effects of Silver, Copper Oxide, Cerium Oxide, and Cobalt Oxide Nanoparticles and Silver and Copper Sheets Against COVID‐19
Authors: Norouzi Aida , Mansouri Sobhan , Mardani Rozita , Nematollahi Mohammad Hadi , Abolhassani Moslem , Norouzmahani Mohammad Erfan , Najmadini Atefeh , Sardari Ali Abbasi , Asadikaram Gholamreza 
Published: August 2024

AbstractCOVID‐19 the most devastating pandemic of the current millennium, can survive from hours to months in environment, devices, and surface. Its transmission by asymptomatic carriers has significantly strained the existing testing resources. At present, there are no clinically proven therapeutic methods that effectively inhibit the effects of this virus. Nanoparticles (NPs) have been extensively utilized in various medical applications, including biosensing, drug delivery, imaging, and antimicrobial/antiviral treatment. Synthetic NPs can closely resemble the virus and strongly interact with its proteins due to their similar morphology. Therefore, NP‐based strategies for combating this virus hold immense potential and may reduce the survivability of the virus in the environment due to unique physicochemical features and surface modification properties. In this study, antiviral properties of silver (Ag), copper oxide (CuO), cobalt oxide (Co3O4), and cerium oxide (CeO2) NPs besides Ag and Cu sheets against COVID‐19 in nasopharyngeal samples were investigated. All NPs suspensions were prepared in Virus Transporter Media (VTM) in 25, 50, and 100 mg/mL concentrations, additionally, Cu and Ag sheets were added to SARS‐CoV‐2 virus pooled and then incubated at room temperature. Viral RNA was extracted from those suspensions after different incubation times and concentrations and quantitative polymerase chain reaction (qPCR) analysis was performed. For virucidal activity evaluation, the estimated lysed virus copy number was assessed according to the pooled virus sample serial dilution and eventually based on changes in the cycle threshold (CT) of qPCR. According to CT number changing after incubation of NPs with pooled virus sample, CuO NPs had the greatest virus inactivation on virus lysis at all concentrations and times while Co3O4 NPs showed moderate antiviral activity (P<0.05). The antiviral activity of other NPs was less than CuO and Co3O4 and were almost identical at similar concentrations and times. Cu and Ag sheets have shown a direct linear relationship between incubation time and antiviral activity. Cu nanoparticles had significant destructive effects on the SARS‐CoV‐2 virus among all nanoparticles, and the Cu sheet had considerably less antiviral activity than its own Cu NPs. These findings might make it helpful to use CuO NPs in masks, and air/water filters, make coated surfaces with effective NPs, and manufacture disinfectant solutions to combat coronaviruses and other viruses that can cause respiratory infections.
An observational study on the efficacy of targeted therapy for pulmonary sarcomatoid carcinoma
Authors: Tsuda Takeshi , Ichikawa Tomomi , Matsumoto Masahiro , Mizusihima Isami , Azechi Kenji , Takata Naoki , Murayama Nozomu , Hayashi Kana , Hirai Takahiro , Seto Zenta , Tokui Kotaro , Masaki Yasuaki , Taka Chihiro , Okazawa Seisuke , Kambara Kenta , Imanishi Shingo , Taniguchi Hirokazu , Miwa Toshiro , Hayashi Ryuji , Matsui Shoko , Inomata Minehiko 
Published: August 2024

Abstract
Background
Pulmonary sarcomatoid carcinoma is a rare tumor that is resistant to cytotoxic agents. This observational study aimed to evaluate the detection rate of driver gene alteration and the efficacy of targeted therapy for pulmonary sarcomatoid carcinoma.

Methods
We established a database of patients with pulmonary sarcomatoid carcinoma and their clinical information, including EGFR mutation, ALK fusion gene, ROS1 fusion gene, BRAF mutation, and MET exon 14 skipping mutation. The present study retrieved and analyzed the data of patients with pulmonary sarcomatoid carcinoma in whom driver gene alterations were evaluated, and the survival duration after the initiation of treatment with targeted therapy was examined.

Results
A total of 44 patients were included in the present study. The EGFR mutation, ALK fusion gene, and MET exon 14 skipping mutation were detected in 2/43 patients (4.7%), 2/34 patients (5.9%), and 2/16 patients (12.5%), respectively. The ROS1 fusion gene (0/18 patients) and BRAF mutation (0/15 patients) were not detected. Female patients (P = 0.063, Fisher’s exact test) and patients without smoking history (P = 0.025, Fisher’s exact test) were the dominant groups in which any driver mutation was detected. Five patients with driver gene alterations were treated with targeted therapy. Progression-free survival (PFS) was 1.3 months and 1.6 months in 2 of the patients treated with gefitinib. Two patients with the ALK fusion gene showed 2.1 and 14.0 months of PFS from the initiation of treatment with crizotinib, and a patient with the MET exon 14 skipping mutation showed 9.7 months of PFS from the initiation of treatment with tepotinib.

Conclusion
The EGFR mutation, ALK fusion gene, and MET exon 14 skipping mutation were detected in patients with pulmonary sarcomatoid carcinoma in clinical practice, and some patients achieved long survival times after receiving targeted therapy. Further investigation is necessary to evaluate the efficacy of targeted therapy for pulmonary sarcomatoid carcinoma.
A comparative assessment of Lead (Pb) concentration and physicochemical parameters in groundwater from the Kabwe mine and Lusaka non-mine sites, Zambia
Authors: Siame Tasha , Muzandu Kaampwe , Kataba Andrew , Weisiyu Qin , M’kandawire Ethel 
Published: August 2024

AbstractThis study addresses the comparative influence of physicochemical parameters on the dissolution of Pb and its levels in the groundwater of former Pb mining areas in Kabwe and non-mining areas in Lusaka, Zambia. This cross-sectional study analyzed 61 groundwater samples from hand pump boreholes using atomic absorption spectrometry. Physicochemical parameters were measured, including electrical conductivity (EC), temperature, total dissolved solids (TDS), and pH. Statistical analysis involved the Wilcoxon test, Spearman’s correlation, robust linear regression, Principal component analysis (PCA), and generalized additive models. Pb concentrations were particularly higher (p = 0.029; median = 0.131 mg/L) in mining areas compared to non-mining areas (median = 0.071 mg/L). The EC in the mining areas (median = 585 µS/cm) was significantly (p = 0.001) lower than those in the non-mining area (median = 1100 µS/cm). Likewise, TDS levels revealed a significant (p = 0.001) difference between the mining area (median = 303 ppm) and the non-mining area (median = 601 ppm). The median pH values for groundwater samples in the mining and non-mining areas were 6.96 and 7.27, respectively. Spearman’s rank correlation revealed a significant (rho = − 0.405; p = 0.036) inverse relationship between Pb concentrations and pH in non-mining areas. Robust linear regression and generalized additive models underscored a significant (p = 0.016) non-linear relationship between temperature and Pb across all areas, with the non-mining area demonstrating a significant (p = 0.003) non-linear relationship between temperature and pH concerning Pb. The study associates mining activities with increased Pb concentrations, underscoring it as a principal contamination source. In contrast, elemental dissolutions from the basement limestone with dolomite might increase Pb concentration in the non-mining areas. The observed positive relationship between temperature and pH in non-mining areas highlights its positive interactions with Pb mobility while temperature greatly influences Pb dissolutions in mining areas.
Autumn Warming of the Cold Intermediate Layer in the Labrador Shelf
Authors: Hu Rou , Zhao Jian 
Published: August 2024

AbstractThe Labrador Shelf is integral to the North Atlantic Ocean's climate system, exerting a significant influence on both regional and global scales. This study examines continuous, high‐temporal resolution hydrographic profiles collected by two Argo floats located on the Labrador Shelf. Our focus centers on the subsurface changes. Among observed seasonal variations, the most pronounced and consistent change is a marked temperature increase during autumn in the Cold Intermediate Layer, which is also confirmed in an eddy resolving global reanalysis data set. Contrary to previous studies that attributed this warming to the autumnal deepening of the mixed layer, our analysis indicates that the warming extends to underneath the deepest mixed layer. Thus, mixed layer development cannot account for the observed warming in the deeper layer. On the other hand, analysis of velocity fields from reanalysis data set reveals active onshore intrusions at several locations, with a section at 58°N emerging as the northernmost hotspot. Budget analysis further indicates that the dominant factor driving autumn warming at Section 58°N is cross‐isobath advection that is associated with the intrusion of slope waters onto the shelf. Subsequently, the positive temperature anomaly at Section 58°N and other enhanced intrusion locations are transported downstream through along‐isobath currents, resulting in lagged yet intensified warming at lower latitudes. Our findings underscore the essential role of cross‐isobath intrusion, in combination with along‐isobath movements in governing seasonal temperature variability in the deep layer of the Labrador Shelf. Incorporating this mechanism is crucial for accurately hindcasting and forecasting bottom environmental conditions in the region.
Assessing the Potential for Medium‐Range Ice Forecasts in the Laurentian Great Lakes
Authors: Yeo A. J. , Anderson E. J. , Jablonowski C. , Wright D. M. , Mann G. E. , Fujisaki‐Manome A. , Mroczka B. , Titze D. 
Published: August 2024

AbstractReal‐time forecasted ice information for large lakes, such as the Great Lakes, is critical for essential operations, such as ice breaking, commercial navigation, search and rescue, and oil spill response. Existing forecast products for large lake ice conditions are not available for medium‐range time horizons (5–16 days out), yet they could provide important information for decision making, particularly for ice breaking and spill responses. In addition, ice forecasts for Earth's largest lakes at these timescales could be important for Medium‐Range Weather (MRW) forecasting. However, the skill of existing operational products in predicting ice conditions at MRW timescales has not been studied. This work aims to determine how well ice forecasts from a coupled large lake hydrodynamic‐ice model perform for MRW forecast horizons. Simulations were carried out for the 2022 Great Lakes ice season, using 8 different 16‐day forecast periods. Forecast results were compared to observations of meteorology and ice conditions from the U.S. National Ice Center. Results show the MRW ice forecasts in the Great Lakes outperform persistence‐based forecasts. These findings could inform the development or extension of lake operational ice forecasting and the potential of coupling between atmospheric and large lake models at medium‐range forecast time scales.
Dispensed prescription medications and short-term risk of pulmonary embolism in Norway and Sweden
Authors: Aune Dagfinn , Vardaxis Ioannis , Lindqvist Bo Henry , Brumpton Ben Michael , Strand Linn Beate , Horn Jens Wilhelm , Bakken Inger Johanne , Romundstad Pål Richard , Mukamal Kenneth J. , Ljung Rickard , Janszky Imre , Sen Abhijit 
Published: August 2024

AbstractScandinavian electronic health-care registers provide a unique setting to investigate potential unidentified side effects of drugs. We analysed the association between prescription drugs dispensed in Norway and Sweden and the short-term risk of developing pulmonary embolism. A total of 12,104 pulmonary embolism cases were identified from patient- and cause-of-death registries in Norway (2004–2014) and 36,088 in Sweden (2005–2014). A case-crossover design was used to compare individual drugs dispensed 1–30 days before the date of pulmonary embolism diagnosis with dispensation in a 61–90 day time-window, while controlling for the receipt of other drugs. A BOLASSO approach was used to select drugs that were associated with short-term risk of pulmonary embolism. Thirty-eight drugs were associated with pulmonary embolism in the combined analysis of the Norwegian and Swedish data. Drugs associated with increased risk of pulmonary embolism included certain proton-pump inhibitors, antibiotics, antithrombotics, vasodilators, furosemide, anti-varicose medications, corticosteroids, immunostimulants (pegfilgrastim), opioids, analgesics, anxiolytics, antidepressants, antiprotozoals, and drugs for cough and colds. Mineral supplements, hydrochlorothiazide and potassium-sparing agents, beta-blockers, angiotensin 2 receptor blockers, statins, and methotrexate were associated with lower risk. Most associations persisted, and several additional drugs were associated, with pulmonary embolism when using a longer time window of 90 days instead of 30 days. These results provide exploratory, pharmacopeia-wide evidence of medications that may increase or decrease the risk of pulmonary embolism. Some of these findings were expected based on the drugs' indications, while others are novel and require further study as potentially modifiable precipitants of pulmonary embolism.
Identification of factors affecting fattening efficiency of commercial pig herds and analysis of their impact at different performance levels
Authors: Guan Ran , Zheng Zhiwei , Yu Hai , Wu Lili , Huang He , Jiang Ping , Li Xiaowen 
Published: August 2024

AbstractImproving fattening efficiency is an important goal of breeding commercial pigs, especially for the large-scale pig farms. Fattening efficiency index (FEI) can be used to evaluate the fattening efficiency. The aim of this study was to identify the factors affecting the fattening efficiency of commercial pigs in large-scale pig farms and further study the impact of these factors on the production performance of commercial pig batches at different production levels. The data of 9,570 batches was mainly consisted of four parts (farm facilities, general information of piglets, production performance of nursery pigs and finishing pigs). A total of 28 variables were evaluated by the multi-variable linear regression models. The differences in production factors significantly correlated with FEI at piglets-finishing stage were compared among high-performing (HP), moderate-performing (MP), and low-performing (LP) batches of commercial pigs during the nursery and finishing stage. Among the 28 variables, 18 were significantly correlated with fattening efficiency (P < 0.05), including 11 continuous variables and seven discrete variables. The significant differences among the 11 consecutive variables in the HP, MP, and LP batches of commercial pigs mostly persisted from the piglets-nursery stage to the growing-finishing stage, ultimately affecting the FEI at piglets-finishing stage. For the seven significant discrete variables, the HP batches had a lower proportions in owned source of piglets, number of the purchasing piglets in spring and winter, number of batches in the East and North regions and five-way crossbred pigs, while a higher proportions in the use of closed circuit television video (CCTV) and wastes treatment system. The fattening efficiency of commercial pigs in large-scale pig farms was comprehensively affected by farm facilities, piglets, and production performance at nursery and finishing stage. The low fattening efficiency may have started at the end of nursery stage.
Use of Mangrove Rhizophora Mucronata as a Natural Dye in Exploration of Natural Dye Shibori
Authors: Sholikhah Roudlotus , Widowati  , Nurmasitah Sita , Sudiyono  
Published: August 2024

Abstract
This research aimed to determine the results of the motif clarity test, color sharpness test, color evenness test, and color absorption test of the natural dye mangrove Rhizophora mucronata on shibori. The method used in this research is experimental. There are 3 types of samples used, namely sample A (the Kumo shibori technique with a natural dye composition of 1 kg of mangrove mixed with 10 liters of water), sample B (the Kanoko shibori technique with a natural dye composition of 1 kg of mangrove mixed with 8 liters of water), and sample C (the Itajime shibori technique with a natural dye composition of 1 kg of mangrove mixed with 5 liters of water). The data analysis used is descriptive. The research results show that: 1). The results of the motif clarity test in sample A have the clearest motif clarity, namely 4.7; 2). The color sharpness test results for sample C have the sharpest motif sharpness, namely 4.7; 3). The color evenness test results for sample A have the most even color evenness, namely 4.55.; and 4). The color absorption test results for sample C had the best color absorption, namely 4.55.
Planning and Design of the Safe Route to School (SR2S) on the Taman Siswa Road Section, Semarang City
Authors: Sholahudin Farhan , Ayu Hapsari Rahma Nindya , Baharuddin Alfan , Hendardi Agi Rivi , Nurmayadi Dicky 
Published: August 2024

Abstract
The Taman Siswa Road section is an educational area where many students carry out activities both crossing and walking along the road. The high volume of traffic and speed on these roads also has the potential for traffic accidents to occur. The purpose of this study was to analyze the planning and design of the Safe Route to School (SR2S), in the educational area on Taman Siswa Road section, Semarang City. The research method used to planning and design the Safe Route to School (SR2S), is by carrying out traffic surveys including traffic volume surveys, road inventory, vehicle speed, pedestrian volume and movement, pedestrian behavior characteristics and delivery behavior characteristics which are analyzed based on MKJI 1997 and PV2. From the results of the analysis, it was found that the traffic volume was 912 pcu/hour during peak hours and the road capacity was 1,304.331 pcu. So that the road service level is 0.699 with an average speed on Taman Siswa Road Section of 37.65 km/hour. For the analysis of the need for pedestrian crossing facilities at MI Al-Iman Banaran, SD N Sekaran 1, SD N Sekaran 2, and MI Roudlotul Huda, it is recommended to provide pedestrian crossing facilities in the form of zebra cross. For the facilities needed by pedestrians, it is recommended to provide sidewalks with a width of 3 meters. At all school locations that have carried out an analysis of the needs of the Safe School Zone facilities, it was concluded that the road is not safe. For this reason, it is necessary to planning and design the Safe Route to School (SR2S), on the Taman Siswa Road Section which is expected to be of benefit to road users, especially pedestrians in the school area, so that when walking along and crossing the road it provides security and safety for pedestrians.
Analysis of Traffic Accidents on Brigjen Sudiarto Road, Pedurungan District, Semarang City
Authors: Nugroho Untoro , Kusumawardani Rini , Kusbiantoro Arief , Pratama Muhammad Jordan 
Published: August 2024

Abstract
Brigjen Sudiarto roads is a provincial road located in the Pedurungan sub-district, Semarang City, Central Java Province. This research uses this road because in the last 5 years from 2018 to 2022, there have been 230 accidents on this road with a total of 271 accident victims based on accident data from the West Semarang Police. The purpose of this study is to determine the characteristics of traffic accidents on Brigjen Sudiarto road during the 2018 – 2022 period, find out the locations of accident-prone points on Brigjen Sudiarto road, and provide advice as a prevention of traffic accidents in the future. This study describes the current conditions. This study uses the Accident Equivalence Rate (AEK) method and the Upper Control Limit (UCL) method. If the AEK value is greater than the UCL value, it means that the location is an area prone to traffic accidents.
The results of the research are the characteristics of traffic accident data from 2018 – 2022 based on the highest per segment the highest is in segment 3 with a total of 105 incidents, and for all characteristics segment 3 is also the highest recorded. The highest accidents based on time (hour) occurred at 06.01-12.00 WIB with a total of 86 incidents, the highest accidents based on day occurred on Wednesday with a total number of 38 incidents, the highest accident based on victim class was minor injured victims (LR) with a total number of 200 incidents, the highest accidents based on gender were male victims with a total of 175 incidents, the highest accidents based on age occurred in victims aged (> 48 years) with a total of 71 incidents, and the highest accidents based on the type of vehicle were motorcycles with a total a total of 155 incidents. The results of the analysis of accidents on the Brigjen Sudiarto road which were carried out for five years (2018-2022) based on the Accident Equivalent Number (AEK) method and the Upper Control Limit (UCL) method occurred in segment 3 in 2018 with AEK = 114 and UCL = 82 Segment 1 in 2019 with AEK = 111 and UCL = 97. Segment 3 in 2021 with AEK = 117 and UCL = 93. Segment 3 in 2022 with AEK = 105 and UCL = 102. Meanwhile in 2020 the AEK value does not exceed the UCL value limit. This means 4 years of blackspot and 1 year of no blackspot during the last 5 years. The solution as a step to minimize accidents in segments 3 and 1 is to remake road markings, install traffic warning signs in accident-prone locations and repair damaged roads in accident-prone locations. This solution is expected to be implemented to reduce the occurrence of traffic accidents and casualties.