bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and impact of sleep-related breathing disorder in multiple system atrophy patients: a cross-sectional study and meta-analysis
Authors: Wang Hui , Zhang Ting , Fan Wenhui , Xu Yanming 
Published: August 2024

ObjectiveSleep-related breathing disorder (SRBD) is a prevalent non-motor symptom in multiple system atrophy (MSA). However, the reported prevalence of SRBD in MSA from different studies has shown inconsistency. Additionally, only one study has examined the impact of SRBD on both motor and non-motor symptoms in MSA.MethodsCross-sectional study of 66 patients with probable MSA from China. SRBD was ascertained with polysomnography (PSG). All the MSA individuals were assessed using the Epworth Sleepiness Scale (ESS), Unified Multiple-System Atrophy Rating Scale (UMSARS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), the Mini-mental State Examination (MMSE), Non-Motor Symptoms Scale (NMSS), and Pittsburgh Sleep Quality Index (PSQI). Moreover, a meta-analysis was conducted by searching studies related to MSA and SRBD in PubMed, Web of Science, Embase, and Cochrane databases. Data were pooled as necessary to calculate prevalence of SBRD with 95% confidence intervals (CI).ResultsOur study included 66 patients with MSA, 52 of whom had a diagnosis of SRBD (78.8%). There were no significant differences between the MSA with SRBD and without SRBD groups on the age, sex, disease onset, disease duration, UMSARS I, II, and IV, the NMSS, the HAMA, HAMD, the ESS the FSS, the MMSE, and the PSQI scales. However, MSA patients with SRBD having a significant higher obstructive apnea index and percentage of snoring during sleep than MSA patients without SRBD [10.0 (4.1–10.6) vs. 0.1 (0–0.3), and 8.3 (5.1–12.2) vs. 4.2 (0–7.5)]. Also, between the two groups, the mean and minimum oxygen concentrations during sleep were lower in MSA patients with SRBD than in those without SRBD [93.7 (93–95) vs. 95.5 (95.8–97), p = 0.001] and [83.9 (81.2–89.0) vs. 90.3 (89.8–93.3), p = 0.000]. The primary search strategy identified 701 articles, with 10 meeting the inclusion criteria. The overall prevalence of SRBD in a combined sample of 295 MSA patients was found to be 60.5% (95% CI, 43.2–76.5%). Further analysis revealed that the prevalence of SRBD in MSA patients in Asia was 79.2% (95% CI, 54.7–96.3%), which was higher than that in Europe (41.6, 95% CI, 32–51.5%).ConclusionThe study found a prevalence of 78.8% of SRBD in MSA patients, with a notably higher prevalence in Asia compared to Europe. The majority of SRBD cases in MSA were attributed to obstructive apnea. Furthermore, the presence of SRBD did not show a significant impact on the motor and non-motor symptoms of MSA patients.
Efficacy and safety of hepatic arterial infusion chemotherapy combined with fruquintinib and tislelizumab for patients with microsatellite stable colorectal cancer liver metastasis following failure of multiple-line therapy
Authors: Zheng Kanglian , Zhu Xu , Xu Liang , Cao Guang , Niu Chuanxin , Yan Xiaoluan , Xu Da , Liu Wei , Bao Quan , Wang Lijun , Wang Kun , Xing Baocai , Wang Xiaodong 
Published: August 2024

Background and aimThe prognosis of microsatellite stable (MSS)-colorectal cancer liver metastasis (CRCLM) following failure of multi-line therapy remains dismal. The aim of this study is to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) plus fruquintinib and tislelizumab (HAIC-F-T treatment) for MSS-CRCLM which failed from multiple-line therapy.MethodsFrom February 2021 to June 2023, 45 patients with MSS-CRCLM after failure of multiple-line therapy who received HAIC combined with fruquintinib and tislelizumab (HAIC-F-T triple treatment) were enrolled. The combination therapy included HAIC regimens with oxaliplatin and 5-fluorouracil or irinotecan, oxaliplatin, and 5-fluorouracil on days 1-2, intravenous tislelizumab (200 mg) before HAIC on day 1, and oral fruquintinb (3 mg/d) on day 3-21, every 4 weeks. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method.ResultsThe follow-up ended on June 22, 2024, with a median follow-up time of 17.5 months. The objective response rate was 42.2%, and the disease control rate was 82.2%. The median OS was 15.3 months (95% confidence interval [CI]:12.634-17.966), and the median PFS was 7.5 months (95% CI:5.318-9.682). The independent risk factors related to worse OS were previous PD-1 immunotherapy (P = 0.021) and the number of HAIC-F-T triple treatment cycles of ≤ 2 (P = 0.007). The incidence of grade 3 or higher adverse events (AEs) was 20%, with the most frequent grade 3 or higher AEs being abdominal pain (3/45, 6.7%).ConclusionHAIC combined with fruquintinib and tislelizumab may be an alternative salvage treatment for patients with MSS-CRCLM following failure of multiple-line therapy.
Determinants of neonatal hypoglycemia among neonates admitted to neonatal intensive care units of public hospitals in Wolaita Zone, Southern Ethiopia, 2023: An unmatched case–control study
Authors: Wodajo Dawit Tesfaye , Gebretsadik Woiynshet , Melketsedik Zeleke Aschalew , Desalegn Nathan , Lencha Fikre Moga 
Published: August 2024

BackgroundGlobally, neonatal hypoglycemia is a common child health problem and significantly contributes to morbidity and mortality, with its impact being particularly detrimental in developing countries. Although being a prevalent metabolic condition, it is frequently overlooked. Furthermore, the problem is not adequately studied in Ethiopia, as seen by a few published studies on the topic, highlighting the lack of knowledge about its determinants.ObjectiveThis study aims to assess the determinants of neonatal hypoglycemia among neonates admitted to neonatal intensive care units of public hospitals in Wolaita Zone, Southern Ethiopia, 2023.MethodsAn institution-based unmatched case–control study design was conducted among 249 (83 cases and 166 controls) participants. Data were collected from 29 March to 23 May 2023 using a pretested chart review extraction tool/checklist. A consecutive sampling method was used for participant selection. Data were analyzed using Statistical Package for Social Science version 25. Binary logistic regression analysis was used to identify the determinants of neonatal hypoglycemia, and statistical significance was declared at P &lt; 0.05.ResultsA total of 83 cases and 166 controls were included in the study. The following factors were significantly associated with neonatal hypoglycemia: preterm neonates [adjusted odds ratio (AOR) 4.888 (95% confidence interval, CI, 1.113–21.478)], age of the neonate at admission (3–5 h) [AOR 4.205 (95% CI 1.852–9.547)], hypothermia [AOR 5.485 (95% CI 2.360–12.748)], late initiation of breastfeeding [AOR 6.229 (95% CI 2.665–14.599)], mode of delivery [AOR 5.034 (95% CI 1.688–15.011)], and small for gestational age [AOR 3.645 (95% CI 1.286–10.330)].Conclusion and recommendationIn the current study, numerous determinants of neonatal hypoglycemia have been identified. Therefore, it is crucial to give due emphasis to providing comprehensive health education to mothers regarding effective breastfeeding methods, strategies to avoid neonatal hypoglycemia, and the various factors that heighten its likelihood. In addition, healthcare professionals should emphasize implementing preventive measures to prevent this grave condition.
Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis
Authors: Ling Jing , Yang Xuping , Dong Lulu , Jiang Yan , Zou Sulan , Hu Nan 
Published: August 2024

Voriconazole is a broad-spectrum triazole antifungal agent. A number of studies have revealed that the impact of C-reactive protein (CRP) on voriconazole pharmacokinetics was associated with the CYP2C19 phenotype. However, the combined effects of CYP2C19 genetic polymorphisms and inflammation on voriconazole pharmacokinetics have not been considered in previous population pharmacokinetic (PPK) studies, especially in the Chinese population. This study aimed to analyze the impact of inflammation on the pharmacokinetics of voriconazole in patients with different CYP2C19 genotypes and optimize the dosage of administration. Data were obtained retrospectively from adult patients aged ≥16 years who received voriconazole for invasive fungal infections from October 2020 to June 2023. Plasma voriconazole levels were measured via high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). CYP2C19 genotyping was performed using the fluorescence in situ hybridization method. A PPK model was developed using the nonlinear mixed-effect model (NONMEM). The final model was validated using bootstrap, visual predictive check (VPC), and normalized prediction distribution error (NPDE). The Monte Carlo simulation was applied to evaluate and optimize the dosing regimens. A total of 232 voriconazole steady-state trough concentrations from 167 patients were included. A one-compartment model with first order and elimination adequately described the data. The typical clearance (CL) and the volume of distribution (V) of voriconazole were 3.83 L/h and 134 L, respectively. The bioavailability was 96.5%. Covariate analysis indicated that the CL of voriconazole was substantially influenced by age, albumin, gender, CRP, and CYP2C19 genetic variations. The V of voriconazole was significantly associated with body weight. An increase in the CRP concentration significantly decreased voriconazole CL in patients with the CYP2C19 normal metabolizer (NM) and intermediate metabolizer (IM), but it had no significant effect on patients with the CYP2C19 poor metabolizer (PM). The Monte Carlo simulation based on CRP levels indicated that patients with high CRP concentrations required a decreased dose to attain the therapeutic trough concentration and avoid adverse drug reactions in NM and IM patients. These results indicate that CRP affects the pharmacokinetics of voriconazole and is associated with the CYP2C19 phenotype. Clinicians dosing voriconazole should consider the patient’s CRP level, especially in CYP2C19 NMs and IMs.
Evolutionary distribution and mode transition in medium frequency from 50 kHz to 5 MHz of argon atmospheric pressure dielectric barrier discharge plasma
Authors: Zhao Zhibo , Yu Yilin , Nie Qiuyue , Zhang Zhonglin 
Published: August 2024

Dielectric barrier discharges (DBDs) provide a promising technology for generating non-equilibrium cold plasmas at atmospheric pressure. For both application-focused and fundamental research, it is important to explore the discharge mode transition and electron heating mechanism to enable effective independent tuning of key plasma parameters in a DBD system. In this work, we report numerical studies of the effects of single-frequency excitation on atmospheric argon DBDs, which are carried out in the medium driving frequency (MF) range from 50 kHz to 5 MHz by using a one-dimensional hydrodynamics coupling model. The spatio-temporal evolution of particle density associated with the discharge mode transition and electron dynamic behavior has been investigated. By tuning different components of a single frequency, we observe the electron heating behaviors of the individual modes and mode transitions from the Townsend discharge to the glow discharge in the low frequency to the Ω mode and the hybrid mode in the medium frequency to the α-mode and the γ-mode in the radio frequency. The physical analysis is understood based on these fundamental insights into the plasma physics.
The influence of real-time quantitative feedback and verbal encouragement on adults’ performance in maximal and explosive strength and power in bench press exercise
Authors: Pacholek Martin 
Published: August 2024

BackgroundIn sports practice, a wide array of verbal and non-verbal stimuli can elicit diverse motivations and performance changes. Therefore, the primary objective of this study was to compare the impact of various stimuli on maximal strength and power in bench press exercises.MethodsThis study involved 48 university students (average age 20.5 ± 2.8 years; body mass 80.1 ± 20 kg; height 174.6 ± 6.7 cm; BMI 26.2 ± 6 kg/m2) who engaged in an 8-week resistance training program. The students were randomly divided into three experimental groups and one control group. The first group received real-time quantitative feedback (RF) on their power output during the bench press exercise, the second group received verbal encouragement (VE) from an instructor, and the third group exercised without any external stimulus (WS). The control group (CG) underwent only pre- and post-measurements. To compare differences in strength parameters among groups a Two-Way Repeated Measures ANOVA was applied.ResultsThe results revealed significant improvements in the mean weight for one repetition maximum in the real-time quantitative feedback group (5 kg, 9.76%, p = 0.001, d = 0.529) and the verbal encouragement group (5.42 kg, 11.51%, p = 0.001, d = 1.201). Positive changes were also observed in the mean power at 20 and 30 kg for the RF, VE, and WS groups, but at 40 kg, significant improvement was only seen in the real-time quantitative feedback group (247 W, 31.30%, p = 0.001, d = 1.199).ConclusionThese findings underscore the effectiveness of selected stimuli in enhancing maximum strength and power during bench press exercises, with real-time quantitative feedback proving to be the most effective stimulus for improving both maximal strength and power.
Enhancing drought resistance in Pinus tabuliformis seedlings through root symbiotic fungi inoculation
Authors: Xu Lingjie , He Jiadong , Meng Yu , Zheng Yanyan , Lu Bin , Zhang Jiawen , Zhou Yong 
Published: August 2024

BackgroundDrought constitutes a major abiotic stress factor adversely affecting plant growth and productivity. Plant-microbe symbiotic associations have evolved regulatory mechanisms to adapt to environmental stress conditions. However, the interactive effects of different fungi on host growth and stress tolerance under drought conditions remain unclear.ObjectiveThis study explored the effects of varying polyethylene glycol (PEG-6000) concentrations (0%, 15%, 25%, and 35%) on the growth and physiological responses of two ectomycorrhizal fungi (Suillus granulatus (Sg) and Pisolithus tinctorius (Pt)) and two dark septate endophytes (Pleotrichocladium opacum (Po) and Pseudopyrenochaeta sp. (Ps)) isolated from the root system of Pinus tabuliformis. Specifically, the study aimed to evaluate six inoculation treatments, including no inoculation (CK), single inoculations with Sg, Pt, Po, Ps, and a mixed inoculation (Sg: Pt : Po: Ps = 1:1:1:1), on the growth and physiological characteristics of P. tabuliformis seedlings under different water regimes: well-watered at 70% ± 5%, light drought at 50% ± 5%, and severe drought at 30% ± 5% of the maximum field water holding capacity.ResultsAll four fungi exhibited the capacity to cope with drought stress by enhancing antioxidant activities and regulating osmotic balance. Upon successful root colonization, they increased plant height, shoot biomass, root biomass, total biomass, and mycorrhizal growth response in P. tabuliformis seedlings. Under drought stress conditions, fungal inoculation improved seedling drought resistance by increasing superoxide dismutase and catalase activities, free proline and soluble protein contents, and promoting nitrogen and phosphorus uptake. Notably, mixed inoculation treatments significantly enhanced antioxidant capacity, osmotic adjustment, and nutrient acquisition abilities, leading to superior growth promotion effects under drought stress compared to single inoculation treatments.ConclusionAll four fungi tolerated PEG-induced drought stress, with increased antioxidant enzyme activities and osmotic adjustment substances and they promoted the growth and enhanced drought resistance of P. tabuliformis seedlings.
From developmental theory to effective training: long-term and transfer effects of promoting the quantity–to–number word linkage in first-graders at risk for mathematical difficulties
Authors: Ennemoser Marco , Sinner Daniel , Nguyen Linda , Krajewski Kristin 
Published: August 2024

IntroductionThe model of quantity–to–number word linkage (QNL model) identifies relevant milestones in the process of early numerical acquisition and describes a developmental sequence that can guide the fostering of foundational mathematical abilities in at-risk children. While there is substantial evidence for the predictive value of the quantity-number competencies (QNC) described by the model, evidence supporting the preventive potential of interventions targeting these QNC is so far largely restricted to short-term effects. Findings regarding their long-term preventive impact, especially in terms of transfer to mathematical school achievement, are still limited. This quasi-experimental study aimed to address this gap by evaluating the long-term transfer effects of an intervention program that is strictly derived from the QNL model of mathematical development [QNL training; in German “Mengen, zählen, Zahlen” (MZZ)].MethodsWe assessed the quantity-number competencies of 575 first-graders and identified 119 of them as being at risk for mathematical learning difficulties, who were then assigned to three experimental conditions. Sixty one children received 12 sessions of the QNL training, while 30 underwent training in inductive reasoning. Another 28 children served as a control group, receiving no specific intervention.Results and DiscussionMulti-level analyses confirmed both significant short-and long-term effects in the specifically trained quantity–number competencies as well as transfer effects on subsequent mathematical school achievement. In accordance with previous findings, transfer effects of the QNL training on mathematical school achievement were not yet evident immediately after the intervention but turned out to be significant after a delay of 6 months and remained stable even 15 months after training. Effect sizes ranged from d = 0.32 to d = 1.12. These findings both underscore the preventive potential of interventions that are strictly driven by developmental theory and, conversely, support the theoretical assumptions of the QNL model.
The relationship between physical exercise and sense of social fairness among college students: the chain-mediated role of perceived social support and life satisfaction
Authors: Sui Xiaodong , Zhao Bin , Na Di , Liu Jianwu , Zhang Qi 
Published: August 2024

BackgroundThe development of a stable society is closely linked to a prevalent sense of social fairness. Participating in physical activities, which are inherently social, plays a crucial role in fostering mental stability within social contexts.ObjectiveThis study aims to examine how physical exercise influences the sense of social fairness among college students, focusing on the potential mediating effects of perceived social support and life satisfaction.MethodsThe study surveyed 496 Chinese college students using several scales: the Physical Activity Rating Scale-3 (PARS-3), Perceived Social Support Scale (PSSS), Satisfaction with Life Scale (SWLS), and Social Justice Scale (SJS).Results(1) A positive correlation was found between physical exercise and sense of social fairness (r = 0.151, p &lt; 0.01). A significant direct effect of physical exercise on sense of social fairness was also observed (β = 0.151, t = 3.971, p &lt; 0.01). (2) Physical exercise was a positive predictor of perceived social support (β = 0.113, t = 4.062, p &lt; 0.01), which in turn positively influenced both life satisfaction (β = 0.333, t = 18.047, p &lt; 0.01) and sense of social fairness (β = 0.485, t = 6.931, p &lt; 0.01). Additionally, life satisfaction had a positive effect on sense of social fairness (β = 0.431, t = 3.247, p &lt; 0.01). (3) Both perceived social support and life satisfaction significantly mediated the relationship between physical exercise and sense of social fairness through two pathways: physical exercise → perceived social support → sense of social fairness (mediating effect: 0.055); and physical exercise → perceived social support → life satisfaction → sense of social fairness (mediating effect: 0.016).Conclusion(1) Physical exercise enhances both perceived social support and the sense of social fairness among college students, suggesting that it not only directly contributes to an enhanced sense of social fairness but also fosters supportive social relationships. (2) The influence of physical exercise on the sense of social fairness operates both directly and indirectly through the mediating roles of perceived social support and, sequentially, life satisfaction.
Associations between sugar-sweetened beverages consumption, duration of physical exercise, and depressive symptoms among Tibetan university students at high altitude
Authors: Yang Yang , Liu Jia , Dai Duo 
Published: August 2024

BackgroundDepressive symptoms have become a public health issue of common concern in countries all over the world, and have many negative impacts on university students’ study and life. Depressive symptoms are influenced by many factors, including sugar-sweetened beverages (SSBs) consumption and duration of physical activity. However, no study has been conducted on the association between sugar-sweetened beverage consumption, duration of physical exercise, and depressive symptoms among Tibetan university students at high altitudes.MethodsIn this study, a self-assessment survey of SSBs consumption, duration of physical exercise, and depressive symptoms was conducted on 6,259 (2,745 boys, 43.86%) Tibetan university students aged 19–22 years in Lhasa and Ganzi areas, China, using stratified whole population sampling. The associations were also analyzed using one-way analysis of variance, binary logistic regression analysis, and ordered logistic regression analysis in the generalised linear model.ResultsThe proportions of mild depression symptoms, moderate depression symptoms, and major depressive symptoms among Tibetan boys university students in high-altitude areas of China were 18.0, 22.9, and 1.5%, respectively; the proportions of girls students were 20.1, 21.9, and 1.5%, respectively, 1.5%, and the differences in the detection rates of depressive symptoms between sex were statistically significant (χ2 value = 14.253, p &lt; 0.01). Ordered logistic regression analyses showed that using duration of physical exercise &gt;60 min/d and SSBs ≤1 times/week as the reference group, the duration of physical exercise &lt;30 min/d and SSBs ≥5 times/week groups had the highest risk of developing depressive symptoms was the highest risk (OR = 6.98, 95% CI: 5.05–9.65; p &lt; 0.001).ConclusionThis study confirmed that there was a positive association between SSBs consumption and depressive symptoms and a negative association between the duration of physical exercise and depressive symptoms among Tibetan university students at high altitudes in China. In the future, SSBs consumption should be effectively controlled and the duration of physical exercise should be increased to reduce the occurrence of depressive symptoms and promote the physical and mental health of Tibetan university students in high-altitude areas.