bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating Occupational and Personal Factors Effective in Causing Musculoskeletal Disorders in the Personnel of One of the Hospitals in Zahedan City
Authors: Habybabady Raheleh Hashemi , Dehbashi Akram , Paridokht Fatemeh , Sepehr Parvin , Roveshti Mehram maleki 
Published: July 2024

Introduction: Musculoskeletal disorders are one of the main health problems among health care providers. This study aims to determine Job responsibilities and risk factors for work-related musculoskeletal disorders among the hospital employees of one of the largest hospitals in Zahedan.
Methods: This cross-sectional study was conducted on 194 staff in one of the largest hospitals affiliated with Zahedan University of Medical Sciences. Data were collected using a demographic questionnaire and Cornell Musculoskeletal Discomfort Questionnaire. The collected data were analyzed using SPSS v19 and univariate logistic linear modeling, in addition to Kruskal-Wallis and Mann-Whitney U tests.
Results: The highest average pain score was related to the back(21/10±26/19). Neck pain was more prevalent in people over 40 years old(50%). Women were 4.9 times more likely to experience neck pain than men, and the possibility of back pain in individuals older than 40 years was 2.2 times higher than in those younger than 30. Furthermore, participants with more than 20 years of work experience were 5/4 times more likely to develop knee pain than those working for 5 years and less. There was a significant difference between pain scores in different positions among the hospital staff(p=0/003).
Conclusion: The results of the present study demonstrated that the prevalence of musculoskeletal disorders among nurse assistants, women, elderly people and those with more work experience was higher than other employees, and it is necessary to design and implement targeted and specific interventions to reduce these disorders for different groups in hospitals.
Analyzing the Opinion of the Elites in the Field of Population Policies in the City of Yazd: A Qualitative Study
Authors: Sadati Ahmad Kalateh , Alimondegari Maliheh , Falakodin Zahra , Shiri-Mohammadabad Hamideh , Kalantar Forozandeh 
Published: July 2024

Introduction: Due to the lack and the continuation of low fertility in past decades, it is necessary to review the population policies of the country. In formulating or revising demographic policies, taking effective and timely measures to facilitate the process of marriage and family formation and encouraging young couples to have children is an important and unavoidable necessity in the current conditions of society. The purpose of the current research is to discover and analyze this issue in Yazd province, based on the opinion of elites and policy makers related to the issue.
Methods: This study was conducted using qualitative and grounded theory methods in 2014 in the city of Yazd. The participants in the research were 18 health officials and academic elites from the province. Participants were selected through purposive sampling. Data were collected using a semi-structured interview tool. Data analysis was conducted using both theoretical and free coding methods as well as central and selective coding techniques.
Results: The results showed that while the decision to have children is influenced by social and cultural contexts, it is primarily influenced by social policies. 57 sub-categories and 20 main sub-categories were extracted The themes of the research included rethinking marriage, postponing childbearing, the dangerous world of childlessness, dynamic policy making, family and child support policies. Also, the core category, the vacuum of dynamic, and efficient policy were calculated
Conclusion: The results of the research show that the issue of having children is related to other needs and necessities of the family, such as taking care of children and the economic needs of the family. For this reason, policymakers should support programs that help families in this field and bring some kind of psychological comfort to the family.
Intention to Leave the Service in Nurses During the COVID-19 Pandemic: A Systematic Review Intention to Leave the Service in Nurses During the COVID-19 Pandemic: A Systematic Review
Authors: P Sharifian , P Sharifian 
Published: July 2024

Introduction: Leaving the profession, especially during the COVID-19 pandemic, has become one of the global challenges raised by healthcare service providers. This study aimed to review the tendency of nurses to leave their service during the COVID-19 pandemic.
Materials and Methods: In this systematic review, all the studies conducted inside and outside the country during the period of the COVID-19 pandemic from 2019 to 2022 using the keywords of leaving the service of nurses, leaving the service in COVID, nursing in Covid, willingness to leave the service in Covid, the tendency to leave service, leaving the service of nurses in Covid, resignation from a nursing job, covid and leaving service, from the internal databases Google Scholar, Iranmedex, Magiran, Nindex, MediLib and Noor magazines and external databases WoS, ProQuest, PubMed, Scopus. Were placed the articles that met the inclusion criteria were selected and finally analyzed more closely.
Results: In the extensive search for information, 127 articles were obtained, and 10 articles were finally selected and evaluated during the screening process and review of the inclusion criteria. The results of this review showed that fear of disease, not having enough immunity, having children, not being able to afford personal equipment, inappropriate salary and benefits compared to the difficulty of work, fear of transmitting infection to the family, lack of support from officials, working in the Covid department and the heavy workload during the Covid-19 era was cited as one of the most important reasons for leaving a job.
Conclusion: Choosing life solutions, financial and occupational safety, and more effective support of the authorities towards nurses are among the solutions that can help to continue the nursing profession, especially during crises like COVID-19.
Cataloging metagenome-assembled genomes and microbial genes from the athlete gut microbiome
Authors: Wosinska Laura , Walsh Liam H. , Walsh Calum J. , Cotter Paul D. , Guinane Caitriona M. , O’Sullivan Orla 
Published: July 2024

Aim: Exercise has been increasingly recognized as a potential influencer of the gut microbiome. Nevertheless, findings remain incongruous, particularly in relation to sport-specific patterns.
Methods: In this study, we harness all publicly available data from athlete gut microbiome shotgun studies to explore how exercise may influence the gut microbiota through metagenomic assembly supplemented with short read-based taxonomic profiling. Through this analysis, we provide insights into exercise-associated taxa and genes, including the identification and annotation of putative novel species from the analysis of approximately 2,000 metagenome-assembled genomes (MAGs), classified as high-quality (HQ) MAGs and assembled as part of this investigation.
Results: Our metagenomic analysis unveiled potential athlete-associated microbiome patterns at both the phylum and species levels, along with their associated microbial genes, across a diverse array of sports and individuals. Specifically, we identified 76 species linked to exercise, with a notable prevalence of the Firmicutes phylum. Furthermore, our analysis detected MAGs representing potential novel species across various phyla, including Bacteroidota , Candidatus Melainabacteria , Elusimicrobia , Firmicutes , Lentisphaerae , Proteobacteria , Tenericutes , and Verrucomicrobiota .
Conclusion: In summary, this catalog of MAGs and their corresponding genes stands as the most extensive collection yet compiled from athletes. Our analysis has discerned patterns in genes associated with exercise. This underscores the value of employing shotgun metagenomics, specifically a MAG recovery strategy, for pinpointing sport-associated microbiome signatures. Furthermore, the identification of novel MAGs holds promise for developing probiotics and deepening our comprehension of the intricate interplay between fitness and the microbiome.
Spatial and temporal variations of the 3-year earthquake swarm activities leading up to the M7.6 Noto Peninsula earthquake and interpretations of their activities
Authors: Kumazawa Takao , Ogata Yosihiko 
Published: July 2024

Abstract

The seismic swarm activity that began and expanded in four separate regions in the northern Noto Peninsula at the end of 2020 was followed by the M6.5 earthquake in May 2023, which cascaded into the M7.6 earthquake on New Year's Day 2024. To this series of earthquake events, we estimate temporal changes in the background intensity of the nonstationary ETAS model by inversion for each region. We then interpret how this series of earthquakes was driven by subsurface fluid motion and slow slip at each stage, based on the correspondence between the background seismicity changes and the temporal changes in oblique distance and elevation differences between nearby GNSS stations, as well as the spatiotemporal earthquake patterns.
Surface microstructures of tricalcium phosphate regulate the autophagy of osteoclasts through the MAPK/ERK signaling pathway
Authors: Yang Yuchen , Yang Peipei , Chen Kairui , Huang Biying , Ye Xinxin , Zhao Lingfan , Zhang Qiang 
Published: July 2024

Abstract

The surface microstructures are essential for osteogenesis induced by tricalcium phosphate (TCP). Current studies have mainly focused on the effects on osteoblasts, while the role of its surface microstructure on osteoclasts has been less studied. This study aimed to investigate the effect and mechanism of TCP with different surface microstructures on osteoclasts. The sintering temperature was controlled to produce three different surface microstructures of TCP disks. The behavior of RAW264.7 cells on TCP disk(cell proliferation activity, differentiation, and function), cell autophagy, and the expression of factors in MAPK/ERK signaling pathway were evaluated. The three TCP materials had the same chemical properties and sizes. The surfaces of TCP-compact (TCPc), TCP-middle (TCPm), and TCP-porous (TCPp) were smooth, rough, and the roughest, respectively. The crystal size of TCPc was small, whereas the crystal size of TCP-porous (TCPp) was similar to that of TCPm but larger than that of TCPc. The culture of RAW264.7 cells on the three kinds of TCP disks revealed that the crystal size of the TCP disks had a greater influence on the activity and function of osteoclasts. Osteoclasts cocultured with TCPm and TCPp showed inhibited activity and autophagy, meanwhile the MAPK/ERK signaling pathway was activated in the process. This study demonstrated for that TCP with different surface microstructures may regulate the autophagy in RANKL-induced osteoclasts via ERK1/2 and p38 signaling pathways, sequently affecting osteoclast activity and function in bone fomation.
Mesenchymal Stem Cell-derived exosomes loaded Alitretinoin for TBI repair treatment
Authors: Chen Songyu , Lin Junyu , Zhang Xiaxuan , Yu Peng , Wang Yida , Deng Xianyu , Zhou Lin , Gao Dongming , Gao Liang , Li Lei 
Published: July 2024

Abstract

Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity worldwide. Current clinical treatments often target singular pathological processes, resulting in suboptimal outcomes due to a lack of comprehensive neuroprotective effects. To address this critical gap, we have developed an innovative therapeutic approach utilizing mesenchymal stromal cell (MSC)-derived exosome (Mexo)-coated albumin nanospheres loaded with Alitretinoin (Ali-NPs@Mexo). This novel design aims to enhance neural repair mechanisms, offering a multifaceted approach to neuroprotection and recovery in TBI patients. Our in vitro and in vivo experiments demonstrated that Ali-NPs@Mexo effectively modulates the TBI immuno-microenvironment by attenuating oxidative stress and neuroinflammatory responses. Treatment with Ali-NPs@Mexo was also found to reduce the abnormal activation of astrocytes, which contribute to glial scar formation that hinders neuronal repair. Furthermore, this nanomedicine promoted the proliferation and repair of oligodendrocytes, neural stem cells, and neurons. These findings underscore the potential of Ali-NPs@Mexo as a robust therapeutic strategy for TBI, combining targeted delivery with comprehensive anti-inflammatory, neuroprotective, and reparative effects. The innovative use of MSC-derived exosome-coated nanoparticles ensures enhanced brain targeting and prolonged therapeutic action, making this nanomedicine a promising candidate for clinical translation in the treatment of TBI.
Development of Multi-Objective Production Scheduling Fuzzy Algorithm in Manufacturing
Authors: Piros Attila 
Published: July 2024

Abstract

Several methods exist to schedule specific workpieces in a manufacturing system. Large multinational companies usually apply worldwide automated scheduling systems to provide optimal manufacturing parameters and fulfil the requirements of the lean method. In contrast, an average small-medium sized enterprise (SME) has limited financial and technical resources to complete this task. This paper proposes an ultimately simplified fuzzy inference system, the Compact Mamdani Fuzzy Inference System (CMFIS), to help the scheduling tasks in SMEs. The CMFIS does not require special fuzzy logic knowledge and communicates with the user via Microsoft Excel worksheets. The paper introduces the CMFIS itself and its job shop application as well.
It's time to strike a balance:-Trajectories of health behaviour changes in spouses of people with dementia at high risk for dementia：A qualitative study
Authors: Fang Shuyan , Sun Juanjuan , Gao Shizheng , Song Dongpo , Zhi Shengze , Gu Yanyan , Sun Jiao 
Published: July 2024

Abstract

Background
Multiple studies have shown that spouses of people with dementia (PwD) are two to six times more likely to develop dementia than the general population. By promoting healthy behaviours and improving modifiable risk factors for dementia, 40% of dementia cases could be prevented or delayed. However, little is known about the health behaviour changes after a spouse becomes a primary caregiver. Therefore, the aim of this study was to explore the universally lived experience of spousal caregiver of PwD, identify the trajectory and key nodes events of health behaviour changes in spouses of PwD following their partner's diagnosis to inform the adoption of health behaviours.
Method
A qualitative descriptive study was conducted. Using maximum variation and purposive sampling, 20 spouses of people with dementia with two or more risk factors were recruited for semi-structured interviews.The interviews were transcribed verbatim and analyzed via thematic analysis.
Results
Two themes were identified, in traditional Chinese culture, in the life course of spouses and people with dementia coping with the challenges of dementia, health behaviour changes occur in two directions: (a) priming-leaping-coping: becoming a "smart" caregiver, (b) struggling-trudging-silence: the process by which the self is "swallowed".
Conclusion
The impact of the disease on the process of health behaviour change in spouses is directional, and future interventions must capture the marker nodes at each stage. Spouses must continually balance multiple identity roles to effectively maintain positive health behaviours.
Effective use of dupilumab for eosinophilic gastritis concomitant with severe asthma
Authors: Takeshige Tomohito , Koyama Ryo , Motomura Hiroaki , Okajima Akifumi , Nishioki Toshihiko , Watanabe Junko , Yae Toshifumi , Kido Kenji , Takahashi Kazuhisa 
Published: July 2024

Abstract

Background
Eosinophilic gastrointestinal diseases (EGIDs) are chronic immune-mediated inflammatory disorders characterized by gastrointestinal symptoms and eosinophilic inflammation in specific regions of the gastrointestinal tract. EGIDs are categorized based on the location of eosinophilic inflammation. “Eosinophilic gastritis” (EoG) refers to the condition in which the stomach is involved. In patients with EoG, approved treatment options are restricted despite the high mortality associated with the condition. Therefore, drugs with various pharmacological effects are required. Dupilumab is a human monoclonal antibody directed against the interleukin (IL)-4 receptor α subunit and inhibits the signaling pathways of both IL-4 and IL-13. Additionally, dupilumab has been approved for patients with bronchial asthma, atopic dermatitis, chronic sinusitis with nasal polyposis, prurigo nodularis, chronic spontaneous urticaria, and eosinophilic esophagitis. However, real-world data on the effectiveness of dupilumab for EoG are limited. We present the case of a patient with EoG associated with severe asthma who demonstrated improvement with dupilumab administration.
Case presentation:
A 35-year-old woman who had been treated for asthma complained of worsening intermittent upper abdominal pain. Her dyspnea aggravated and she was admitted to our hospital for asthma exacerbation. Despite the improvement in her asthma symptoms with systemic corticosteroids, her abdominal pain persisted. Upper gastrointestinal endoscopic mucosal biopsy revealed eosinophilic cell infiltration; therefore, the patient was diagnosed with EoG. Dupilumab administration was initiated for asthma, while improvement of secondary EoG was expected. Following dupilumab administration, both EoG and asthma symptoms, disease control, laboratory findings, endoscopic findings, and pathological findings improved. As of now, no adverse events have been reported.
Conclusion
This case report supports that dupilumab could be an effective treatment option for EoG associated with asthma.
The synergistic effect of nitric oxide in Serendipita indica - induced resistance and basal immunity of wheat against powdery mildew
Authors: Li Liang , Qi Fuyan , Feng Yu , Yang Xiurong 
Published: July 2024

Abstract

Aims：The occurrence of wheat powdery mildew caused by Blumeria graminis f. sp. tritici severely hampers the increase of wheat yield. The utilization of biological control in the management of powdery mildew is highly valuable due to its environmentally friendly and sustainable characteristics. The present study investigates the resistance mechanism against powdery mildew by employing a combination of inorganic small molecule NO and endophytic fungus Serendipita indica (S. indica).
Methods：By spraying nitroprusside spraying (NO donor) on wheat leaves and inoculating of roots with S. indica, the effects of combined application of NO and S. indica on powdery mildew were determined through analysis of physiological and biochemical indexes, transcriptome and metabolome data.
Results：Experimental data have demonstrated that pre-colonization with S. indica, followed by sodium nitroprusside spraying (NO donor), reduce 27.9% disease index caused by Blumeria graminis f. sp. tritici and elevate biomass by 20% in wheat. The synergistic application of both treatments (NO+S. indica) effectively enhancedchlorophyll content in leaves and relative water content in roots, significantly decreased the accumulation of malondialdehyde and electrical conductivity in leaves. Furthermore, this combination promotes antioxidant activity in wheat leaves through their synergistic effect. Transcriptome sequencing revealed that sodium nitroprusside alone did not induce a substantial number of differentially expressed genes; however, co-administration of NO and S. indica had a greater impact on transcriptomic changes. Differential expressed geneswere validated by fluorescence quantitative PCR analysis. Metabolic profiling indicated that co-application of NO and S. indicaled to broader alterations across metabolic pathways. Notably, plant hormones such as gibberellin, auxin, and salicylic acid exhibited significant increases upon combined treatment.
Conclusions：The study presents a novel research concept and tactic for the biological management of powdery mildew in wheat.
Adult maxillary expansion: CBCT evaluation of skeletal changes and determining an efficiency factor between force-controlled polycyclic slow activation and continuous rapid activation for mini-screw-assisted palatal expansion - MASPE vs MARPE.
Authors: Walter Andre , Winsauer Heinz , Crespo Eduardo , Walter David , Winsauer Clemens , Schwärzler Alexander , Mojal Sergi , Arcos Ignacio , Puigdollers Andreu 
Published: July 2024

Abstract

Aim: This consecutive retrospective study compared Mini-implant Assisted Slow Palatal Expansion (MASPE) with rapid palatal expansion (MARPE) using a bone-borne skeletal expander in adults with a narrow maxilla. CBCT scans analyzed transverse changes and potential pterygoid process deformation before (T1) and after expansion (T2).
Material and Methods: The Force Controlled PolyCyclic (FCPC) SLOW palatal expansion group (FCPC-MASPE-G) comprised 35 adults aged 18-54 years and received a skeletal expander limiting expansive force only allowing 500 cN at the activation wrench (force control). Discontinuous, polycyclic activations according to the FCPC-protocol were applied. The MARPE-group (n=6) underwent continuous RAPID activation without FCPC until the desired width was reached. CBCT scans were taken pre and post-expansion. Inclusion criteria for both groups were successful outcomes without surgical assistance.
Results: The maxilla opened transversally in both groups mildly V-shaped, with a pyramidal shape in the coronal plane, impacting the zygomatic bone. Width measurements at T2 indicated superior mechanical response in FCPC-MASPE-G. Response of zygomaticomaxillary sutures was similar in both groups. Pterygoid process deformations were notably less in FCPC-MASPE-G (0.87 - 1.35 mm) compared to MARPE-G (2.70 - 3.04 mm). Dental measurements were similar, but the ratio “Mid-palatal suture Opening Related to Expander opening” (M.O.R.E.-factor) was better with 84% in FCPC-MASPE-G than with 50% in MARPE-G.
Conclusion: Slow expansion with FCPC protocol effectively widens the maxilla in adults, with significant impact on bones and sutures and less pterygoid process deformation compared to rapid expansion. Cranial complications were absent in both groups.
First-principles calculations of mechanical properties of TiZrNbTaMo series biological refractory high-entropy alloys
Authors: Wu Yanan , Zhang Yun , Liu Jingshun , Li Ze , Zhao Erjun 
Published: July 2024

Abstract

TiZrNbTaMo series refractory high-entropy alloys (RHEAs) exhibit significant potential in biomedical implant applications due to their outstanding mechanical properties and biocompatibility. Based on first-principles calculations combined with the virtual crystal approximation method, the influence of various element contents on the mechanical properties of TiZrNbTaMo series RHEAs has been investigated in this study. By calculating the physical parameters such as elastic properties, hardness, yield strength, and dislocation energy factor of TiZrNbTaMo RHEA with various element contents, it is found that the addition of Nb element can increase the Cauchy pressure value of the alloy, thereby improving the metallic properties of atomic bonds. Increasing the Ta and Mo content significantly boosts the Young's modulus and hardness of the alloy, while also enhancing its resistance to volume and shear deformation. And among, TiZrNbTa0.5Mo RHEA exhibits the largest dislocation width, lower stacking fault energy, and is more susceptible to twinning deformation than other RHEAs. However, increasing Ti and Zr content enlarges the dislocation width of the alloy, making it more prone to slip. To sum up, this study provides a theoretical reference for further investigation into the mechanical property changes of TiZrNbTaMo series RHEAs.