bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Spirochensilides A and B, Two New Rearranged Triterpenoids from Abies chensiensis.
Authors: Zhao Qian‐Qian , Song Qiu‐Yan , Jiang Kan , Li Guang‐Da , Wei Wen‐Jun , Li Ya , Gao Kun 
Published: October 2015

Abstractisolation, structural elucidation, plausible biogenetic pathway and antiinflammatory activity of the title triterpenoids which possess a unique 8,10‐cyclo‐9,10‐seco and methyl‐rearranged carbon skeleton
ChemInform Abstract: Salicifoxazines A and B, New Cytotoxic Tetrahydro‐1,2‐oxazine‐containing Tryptamine‐Derived Alkaloids from the Leaves of Chimonanthus salicifolius.
Authors: Ma Guang‐Lei , Yang Guo‐Xun , Xiong Juan , Cheng Wen‐Liang , Cheng Ke‐Jun , Hu Jin‐Feng 
Published: October 2015

AbstractSalicifoxazines A (I) and B (II) together with six known dimeric tryptamine derived alkaloids are isolated from the leaves of chimonanthus salicifolius.
Investigation of the Aggregation Properties of a Chiral Porphyrin Bearing Citronellal Meso Substituent Groups
Authors: Castriciano Maria Angela , Zagami Roberto , Trapani Mariachiara , Romeo Andrea , Patanè Salvatore , Monsù Scolaro Luigi 
Published: October 2015

AbstractA new porphyrin bearing four R or S hydrogenated citronellal units directly bound to the meso positions of the porphyrin ring was synthesized and fully characterized through MALDI‐TOF, NMR, UV/Vis absorption, and fluorescence emission spectroscopies. Both enantiomers exhibit a monomeric nature in a series of organic solvents. Acting on the polarity of the solvent, i.e., increasing the amount of water in mixture with acetone, aggregation occurs, as revealed by UV/Vis absorption, fluorescence emission, and resonance light scattering. The occurrence of both H‐ and J‐type aggregates was suggested by fluorescence lifetime measurements. In contrast to the monomeric species, these aggregates exhibit CD spectra reflecting the chirality of the building blocks. AFM microscopy shows that micrometer ribbon‐like structures form by the casting solution of these porphyrins in acetone/water onto a glass surface. Chirality 27:900–906, 2015. © 2015 Wiley Periodicals, Inc.
State of the Art in Steel Mill Dust Recycling
Authors: Antrekowitsch Jürgen , Rösler Gernot , Steinacker Stephan 
Published: October 2015

AbstractThe Waelz technology still represents the main process for treating electric arc furnace dust (EAFD). Interesting developments within this process and some new approaches transform the product into a competitor for the primary metallurgical industry by producing high grade zinc from the Waelz oxide. Another progress constitutes the utilization of the slag, which turns the Waelz technology into a zero‐waste process. An outlook regarding the future role of low zinc‐containing EAFD from basic oxygen furnaces and an overview concerning the world‐wide generation of EAFD and possible future solutions are described as well.
Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
Authors: Jacobs Leon , de Kock Carmen , de Villiers Katherine A. , Smith Peter J. , Smith Vincent J. , van Otterlo Willem A. L. , Blackie Margaret A. L. 
Published: October 2015

Abstract7‐Chloroquinoline‐based antimalarial drugs are effective in the inhibition of hemozoin formation in the food vacuole of the Plasmodium parasite, the causative agent of malaria. We synthesized five series of ferroquine (FQ) and phenylequine (PQ) derivatives, which display good in vitro efficacy toward both the chloroquine‐sensitive (CQS) NF54 (IC50: 4.2 nm) and chloroquine‐resistant (CQR) Dd2 (IC50: 33.7 nm) strains of P. falciparum. Several compounds were found to have good inhibitory activity against β‐hematin formation in an NP‐40 detergent assay, with IC50 values ranging between 10.4 and 19.2 μm.
Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues
Authors: Nicolaou K. C. , Rhoades Derek , Wang Yanping , Totokotsopoulos Sotirios , Bai Ruoli , Hamel Ernest 
Published: October 2015

AbstractThe design, synthesis, and biological evaluation of a series of epothilone analogues with novel side chains equipped with an amino group are described. Their design facilitates potential conjugation to selective drug delivery systems such as antibodies. Their synthesis proceeded efficiently via Stille coupling of a readily available vinyl iodide and heterocyclic stannanes. Cytotoxicity studies and tubulin binding assays revealed two of these analogues to be more potent than epothilones A–D and the anticancer agent ixabepilone, currently in clinical use.
Risk factors for refeeding hypophosphatemia in Japanese inpatients with anorexia nervosa
Authors: Kameoka Naomi , Iga Jun‐ichi , Tamaru Mai , Tominaga Takeo , Kubo Hiroko , Watanabe Shin‐Ya , Sumitani Satsuki , Tomotake Masahito , Ohmori Tetsuro 
Published: October 2015

ABSTRACTObjectiveRefeeding in patients with anorexia nervosa (AN) is associated with a risk of refeeding syndrome, which is a disruption in metabolism with a variety of features including hypophosphatemia. We evaluated the risk factors for refeeding hypophosphatemia (RH) during nutritional replenishment in Japanese patients with AN.MethodsWe retrospectively examined clinical data for 99 female inpatients (mean age 30.9 ± 10.7 years; range, 9 − 56 years).ResultsRH (phosphate < 2.3 mg/dL) occurred within 4.8 ± 3.7 days of hospital admission and was still observed at 28 days after admission in 21 of the 99 cases (21.2%). Oral or intravenous phosphate was given to some patients to treat or prevent RH. Patients with RH had a significantly lower body mass index, were older, and had higher blood urea nitrogen than those without RH. Severe complications associated with RH were recorded in only one patient who showed convulsions and disturbed consciousness at Day 3 when her serum phosphate level was 1.6 mg/dL.ConclusionsThe significant risk factors for RH that we identified were lower body mass index, older age, and higher blood urea nitrogen at admission. No significant difference in total energy intake was seen between the RH and no RH groups, suggesting that RH may not be entirely correlated with energy intake. Precisely predicting and preventing RH is difficult, even in patients with AN who are given phosphate for prophylaxis. Thus, serum phosphate levels should be monitored for more than 5 days after admission. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:402–406).
Effects of fasting and nutritional restriction on the isotopic ratios of nitrogen and carbon: a meta‐analysis
Authors: Hertz Eric , Trudel Marc , Cox Marlin K. , Mazumder Asit 
Published: October 2015

AbstractMany organisms experience fasting in their life time, and this physiological process has the potential to alter stable isotope values of organisms, and confound interpretation of food web studies. However, previous studies on the effects of fasting and starvation on stable isotopes show disparate results, and have never been quantitatively synthesized. We performed a laboratory experiment and meta‐analysis to determine how stable isotopes of δ15N and δ13C change with fasting, and we tested whether moderators such as taxa and tissue explain residual variation. We collected literature data from a wide variety of taxa and tissues. We surveyed over 2000 papers, and of these, 26 met our selection criteria, resulting in 51 data points for δ15N, and 43 data points for δ13C. We determine that fasting causes an average increase in the isotopic value of organisms of 0.5‰ for δ15N and that the only significant moderator is tissue type. We find that the overall effect size for δ13C is not significant, but when the significant moderator of tissue is considered, significant increases in blood and whole organisms are seen with fasting. Our results show that across tissues and taxa, the nutritional status of an organism must be considered when interpreting stable isotope data, as fasting can cause large differences in stable isotope values that would be otherwise attributed to other factors.
A comparative approach to testing hypotheses for the evolution of sex‐biased dispersal in bean beetles
Authors: Downey Michelle H. , Searle Rebecca , Bellur Sunil , Geiger Adam , Maitner Brian S. , Ohm Johanna R. , Tuda Midori , Miller Tom E. X. 
Published: October 2015

AbstractUnderstanding the selective forces that shape dispersal strategies is a fundamental goal of evolutionary ecology and is increasingly important in changing, human‐altered environments. Sex‐biased dispersal (SBD) is common in dioecious taxa, and understanding variation in the direction and magnitude of SBD across taxa has been a persistent challenge. We took a comparative, laboratory‐based approach using 16 groups (species or strains) of bean beetles (genera Acanthoscelides, Callosobruchus, and Zabrotes, including 10 strains of one species) to test two predictions that emerge from dominant hypotheses for the evolution of SBD: (1) groups that suffer greater costs of inbreeding should exhibit greater SBD in favor of either sex (inbreeding avoidance hypothesis) and (2) groups with stronger local mate competition should exhibit greater male bias in dispersal (kin competition avoidance hypothesis). We used laboratory experiments to quantify SBD in crawling dispersal, the fitness effects of inbreeding, and the degree of polygyny (number of female mates per male), a proxy for local mate competition. While we found that both polygyny and male‐biased dispersal were common across bean beetle groups, consistent with the kin competition avoidance hypothesis, quantitative relationships between trait values did not support the predictions. Across groups, there was no significant association between SBD and effects of inbreeding nor SBD and degree of polygyny, using either raw values or phylogenetically independent contrasts. We discuss possible limitations of our experimental approach for detecting the predicted relationships, as well as reasons why single‐factor hypotheses may be too simplistic to explain the evolution of SBD.
1,2,4‐Triazole‐Based N‐Heterocyclic Carb­ene Nickel Complexes – Synthesis and Catalytic Application
Authors: Bheeter Linus P. , Wei Duo , Dorcet Vincent , Roisnel Thierry , Ghosh Prasenjit , Sortais Jean‐Baptiste , Darcel Christophe 
Published: October 2015

AbstractFour nickel complexes bearing 1,2,4‐triazole‐based N‐heterocyclic carbene backbones and a cyclopentadienyl ligand were prepared from the corresponding 1,2,4‐triazolium salts and nickelocene in tetrahydrofuran (THF) under reflux. The obtained complexes were fully characterized, including by X‐ray diffraction analysis. They were then used as catalysts (5 mol‐%) for the borylation of aryl bromide derivatives with bis(pinacolato)diboron in the presence of Cs2CO3 as the base in THF at 70 °C for 20 h to form the corresponding borylated products in moderate yields.
Electronic Lability in a Dinuclear Cobalt–Bis(dioxolene) Complex
Authors: Madadi Azadeh , Itazaki Masumi , Gable Robert W. , Moubaraki Boujemaa , Murray Keith S. , Boskovic Colette 
Published: October 2015

AbstractRemarkable electronic lability is evident from a preliminary study of a dinuclear cobalt complex with a bis(dioxolene) bridging ligand and tetraazamacrocylic ancillary ligands. Structural, magnetic, spectroscopic, and electrochemical data indicate coinciding metal‐ and ligand‐based mixed‐valence involving cobalt(II)/cobalt(III) and catecholate/semiquinonate couples. A thermally stimulated spin‐crossover or valence‐tautomeric transition is also observed above 200 K.
Easy Access to 1H‐Pyrrolo[3′,4′:5,6]pyrido[2,3‐d]pyrimidine‐2,4,6,8(3H,7H)‐tetraone and Selectively N7‐Substituted Analogues through Key Synthons
Authors: Tourteau Aurélien , Merlet Eric , Bontemps Alexis , Leland Mathilde , Helissey Philippe , Giorgi‐Renault Sylviane , Desbène‐Finck Stéphanie 
Published: October 2015

AbstractTo synthesize unsubstituted pyrrolo[3′,4′:5,6] pyrido[2,3‐d]pyrimidine‐2,4,6,8‐tetraone, we have developed new synthon 4‐formyl‐3‐hydroxy‐2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrole, which was then treated under mild conditions with 6‐aminouracil. This new synthetic pathway could be extended to the preparation of N7‐selectively substituted heterocycles by starting either from this new synthon or from its N‐substituted analogues. Examples of N1,N7‐disubstituted and N1,N3,N7‐trisubstituted derivatives are also described. We have thus developed new synthons that lead to easy access to the unsubstituted pyrrolo[3′,4′:5,6]pyrido[2,3‐d]pyrimidine‐2,4,6,8‐tetraone skeleton and to selectively N7‐substituted analogues.
Regioselective [1N+2C+2C] Assembly of Fully Decorated Pyrroles from Primary Amines, 1,2‐Diaza‐1,3‐dienes, and 2,3‐­Allenoates
Authors: Perrulli Francesca R. , Favi Gianfranco , De Crescentini Lucia , Attanasi Orazio A. , Santeusanio Stefania , Mantellini Fabio 
Published: October 2015

AbstractA mild, sequential multicomponent reaction strategy for the regioselective synthesis of functionalized pentasubstituted pyrroles from readily accessible primary amines, 1,2‐diaza‐1,3‐dienes, and 2,3‐allenoates, has been developed. The process allows a [1N+2C+2C] annulation to be achieved through two sequential hydroamination reactions followed by an enamine‐carbocyclization. Moreover, allenoates, as synthetic equivalents of monoactived alkynes, permit the specific preparation of multifunctionalized pyrroles.
Solvent‐Free Ball‐Milling Biginelli Reaction by Subcomponent Synthesis
Authors: Sahoo Prasit Kumar , Bose Anima , Mal Prasenjit 
Published: October 2015

AbstractWe report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof‐of‐concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system. Reactions were performed under solvent‐free, metal‐free, mechanochemical (ball milling) and ambient laboratory conditions. Br+‐catalyzed oxidation of benzyl alcohols led to the product benzaldehydes and byproduct H+ which were further promoted as component and catalyst, respectively, for a cascade transformation to dihydropyrimidones within the same reaction pot. Remarkably, in solution, the reaction system could not be reproduced at room temperature even after 24 h.
A Modular Synthesis of Multidentate S‐, N‐ and O‐Containing Meta‐ and Paracyclophanes
Authors: Rasheed Omer K. , Bailey Patrick D. , Lawrence Amy , Quayle Peter , Raftery James 
Published: October 2015

AbstractThe development of a modular approach to macrocycle assembly has enabled the synthesis of a library of pyridine‐based macrocycles possessing multiple donor sites where chirality was readily introduced from (R)‐ or (S)‐alanine, a representative amino acid. The facile, regioselective, nucleophilic ring opening of aziridines by dithiols enabled the synthesis of thioether‐based linkers which on subsequent alkylation provided access to optically pure macrocycles.
Anxiolytic and antidepressant‐like effects of Ferulago angulata essential oil in the scopolamine rat model of Alzheimer's disease
Authors: Bagci Eyup , Aydin Emel , Mihasan Marius , Maniu Calin , Hritcu Lucian 
Published: October 2015

AbstractFerulago angulata subsp. carduchorum (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, haemorrhoids, snake bites, ulcers and as a sedative. The present study analysed the possible anxiolytic, antidepressant and antioxidant properties of F. angulata essential oil in a scopolamine‐induced rat model of Alzheimer's disease. The anxiolytic and antidepressant‐like effects of F. angulata essential oil were studied using in vivo (elevated plus‐maze and forced swimming tests) approaches. Also, the antioxidant activity in the amygdala was assessed using superoxide dismutase, glutathione peroxidase and catalase specific activities, the total content of the reduced glutathione, protein carbonyl and malondialdehyde levels. The scopolamine‐treated rats exhibited the following: a decrease in the percentage of the time spent and the number of entries in the open arm within the elevated plus‐maze test and a decrease of swimming time and an increase of immobility time in the forced swimming test. Inhalation of F. angulata essential oil significantly exhibited anxiolytic and antidepressant‐like effects and also antioxidant potential. Furthermore, in silico studies carried out by employing molecular docking experiments pointed to the existence of strong interactions of monoterpenes from F. angulata essential oil with anxiolytic and antidepressant effects with GABAA receptor. Our results suggest that the F. angulata essential oil inhalation ameliorates scopolamine‐induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala. Copyright © 2015 John Wiley & Sons, Ltd.
Bendamustine for relapsed blastic plasmacytoid dendritic cell leukaemia
Authors: Bétrian Sarah , Guenounou Sarah , Luquet Isabelle , Demur Cécile , Huynh Anne , Ysebaert Loïc , Recher Christian , Huguet Françoise 
Published: October 2015

AbstractOptimal treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare entity of dismal prognosis previously described as CD4+/CD56+ hematodermic malignancies, is not defined. We report five cases of relapsed BPDCN treated with bendamustine hydrochloride, a well‐tolerated bifunctional drug acting as an alkylating and antimetabolite agent. All patients were above the age of 50 years and in advanced disease (early first relapse in two, subsequent relapse in three; multi‐organ involvement in four; previous intensive chemotherapy in five; and stem cell transplantation in four). Four patients were evaluable for response. Two failed therapy, one died from tumor lysis syndrome after rapid blast clearance from blood, and one reached and maintained complete remission for 7 months. Bendamustine should be further evaluated in BPDCN. Copyright © 2015 John Wiley & Sons, Ltd.
Autophagy‐Mediated Degradation of IAPs and c‐FLIPL Potentiates Apoptosis Induced by Combination of TRAIL and Chal‐24
Authors: Xu Jennings , Xu Xiuling , Shi Shaoqing , Wang Qiong , Saxton Bryanna , He Weiyang , Gou Xin , Jang Jun‐Ho , Nyunoya Toru , Wang Xia , Xing Chengguo , Zhang Lin , Lin Yong 
Published: October 2015

ABSTRACTCombination chemotherapy is an effective strategy for increasing anticancer efficacy, reducing side effects and alleviating drug resistance. Here we report that combination of the recently identified novel chalcone derivative, chalcone‐24 (Chal‐24), and TNF‐related apoptosis‐inducing ligand (TRAIL) significantly increases cytotoxicity in lung cancer cells. Chal‐24 treatment significantly enhanced TRAIL‐induced activation of caspase‐8 and caspase‐3, and the cytotoxicity induced by combination of these agents was effectively suppressed by the pan‐caspase inhibitor z‐VAD‐fmk. Chal‐24 and TRAIL combination suppressed expression of cellular FLICE (FADD‐like IL‐1β‐converting enzyme)‐inhibitory protein large (c‐FLIPL) and cellular inhibitor of apoptosis proteins (c‐IAPs), and ectopic expression of c‐FLIPL and c‐IAPs inhibited the potentiated cytotoxicity. In addition, TRAIL and Chal‐24 cooperatively activated autophagy. Suppression of autophagy effectively attenuated cytotoxicity induced by Chal‐24 and TRAIL combination, which was associated with attenuation of c‐FLIPL and c‐IAPs degradation. Altogether, these results suggest that Chal‐24 potentiates the anticancer activity of TRAIL through autophagy‐mediated degradation of c‐FLIPL and c‐IAPs, and that combination of Chal‐24 and TRAIL could be an effective approach in improving chemotherapy efficacy. J. Cell. Biochem. 117: 1136–1144, 2016. © 2015 Wiley Periodicals, Inc.
Indian hedgehog signaling and the role of graft tension in tendon‐to‐bone healing: Evaluation in a rat ACL reconstruction model
Authors: Carbone Andrew , Carballo Camila , Ma Richard , Wang Hongsheng , Deng Xianghua , Dahia Chitra , Rodeo Scott 
Published: October 2015

ABSTRACTThe structure and composition of the native enthesis is not recapitulated following tendon‐to‐bone repair. Indian Hedgehog (IHH) signaling has recently been shown to be important in enthesis development in a mouse model but no studies have evaluated IHH signaling in a healing model. Fourteen adult male rats underwent ACL reconstruction using a flexor tendon graft. Rats were assigned to two groups based on whether or not they received 0N or 10N of pre‐tension of the graft. Specimens were evaluated at 3 and 6 weeks post‐operatively using immunohistochemistry for three different protein markers of IHH signaling. Quantitative analysis of staining area and intensity using custom software demonstrated that IHH signaling was active in interface tissue formed at the healing tendon‐bone interface. We also found increased staining area and intensity of IHH signaling proteins at 3 weeks in animals that received a pre‐tensioned tendon graft. No significant differences were seen between the 3‐week and 6‐week time points. Our data suggests that the IHH signaling pathway is active during the tendon‐bone healing process and appears to be mechanosensitive, as pre‐tensioning of the graft at the time of surgery resulted in increased IHH signaling at three weeks. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:641–649, 2016.
A meta‐analysis of American black duck winter habitat use along the Atlantic Coast
Authors: Ringelman Kevin M. , Williams Christopher K. , Devers Patrick K. , Coluccy John M. , Castelli Paul M. , Anderson Kurt A. , Bowman Jacob L. , Costanzo Gary R. , Cramer Dane M. , Dibona Matt T. , Eichholz Michael W. , Huang Min , Lewis Benjamin , Plattner Dawn M. , Yerkes Tina 
Published: October 2015

ABSTRACTAmerican black duck (Anas rubripes) populations declined by more than 50% between the 1950s and 1990s, and the species serves as a flagship for conserving salt marsh habitats along the Atlantic Coast. Black ducks have generally been well studied throughout the annual cycle, but surprisingly, we lack a synthetic, quantitative understanding of their space use during the winter. This limits our ability to prioritize habitat acquisition and restoration efforts. We used >17,000 telemetry locations from 235 black ducks ranging from Connecticut to Virginia to study home range composition and space use during winter in relation to habitat quality, urbanization, and severe weather. Despite substantial environmental variation, home range sizes were similar among regions and years. Smaller home and core ranges contained a greater proportion of salt marsh habitat, and ducks experiencing more 4‐day freeze events had larger home and core ranges. Ducks exposed to prolonged periods of cold weather had smaller core ranges when those areas comprised more energy‐rich freshwater habitats. When we examined individual telemetry locations, we found that ducks used irregularly inundated high marsh more at night, presumably for foraging, and urban habitats more during the day and evening crepuscular periods. We found that black ducks used regularly inundated low marsh less on days where the temperature never rose above freezing, and instead used subtidal areas and forested wetlands more. Finally, we found ducks were marginally more likely to use freshwater habitats during high tides. Our study confirms that black ducks depend on salt marsh for wintering habitat, and points to an unexpectedly important role for forested wetlands during periods of cold weather. We found no evidence that black ducks avoided urban areas or roads, which supports the inclusion of all available habitats in carrying capacity modeling. We emphasize that new hypothesis‐driven, local telemetry studies are needed to further elucidate the relationships between black duck movements and environmental variation, especially cold weather. Further, given that most remaining coastal wetlands are currently protected via state and federal lands, we suggest black duck habitat management should strive to acquire and restore brackish and forested wetlands in close proximity to coastal marshes. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.