bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancements in Dravet Syndrome Therapeutics: A Comprehensive Look at Present and Future Treatment Horizons: A Focused Review
Authors: Mahesan Aakash , Kamila Gautam , Gulati Sheffali 
Published: August 2024

Abstract
Dravet syndrome (DS) is a developmental epileptic encephalopathy, characterized by fever-triggered focal or hemiclonic seizures at onset with various associated comorbidities like intellectual disability, gait abnormalities, and behavioral issues. It typically advances to drug-refractory epilepsy with multiple seizure semiology. In this review, we give a focused narrative on the treatment aspects of DS. We searched the PubMed database for articles on DS. More than 500 articles were reviewed, of which 55 relevant articles are included in this review. ClinicalTrials.gov database was also accessed for data on ongoing trials. Majority are caused by mutations in the SCN1A gene. Valproate and clobazam are the most commonly used traditional antiseizure medications. Stiripentol, fenfluramine, and cannabidiol are recently approved drugs with promising results. Ketogenic diet and vagus nerve stimulation are commonly tried nonpharmacologic modalities that have shown significant responses. Antisense oligonucleotides and viral vector-mediated gene transfer therapies are on the horizon. This review outlines the current existing treatment rationale, evidence for newly approved drugs, and the future scope of gene therapy in DS.
Inferior parietal lobule stimulation in task-specific focal hand dystonia: A randomized, crossover clinical trial
Authors: Bhadran Seetha Lekshmi , Reghu Anandapadmanabhan , Gupta Rajiv , Radhakrishnan Divya M. , Vishnoi Aayushi , Gupta Anu , Vishnu Venugopalan Y. , Upadhyay Ashish , Kumaran Senthil , Kumar Nand , Bhatia Renu , Bhatia Rohit , Singh Mamta Bhushan , Srivastava Achal K. , Srivastava Padma , Rajan Roopa 
Published: August 2024

Abstract

OBJECTIVE:
To determine the effect of inhibitory repetitive transcranial magnetic stimulation (rTMS) delivered to the left inferior parietal lobule (IPL) on the severity of task-specific focal hand dystonia.

METHODS:
In this randomized, sham-controlled, double-blind crossover study, participants received single sessions of low-frequency (1 Hz) inhibitory rTMS (1200 pulses) and sham stimulation to the left IPL. At baseline and after each session, we assessed the Writer’s Cramp Rating Scale (WCRS), kinematic analysis using an electrogoniometer, a torsiometer, and the patient-reported improvement on a Likert scale.

RESULTS:
We recruited 16 right-handed patients with task-specific focal hand dystonia [age: 33.3 ± 11.7 years, 13 male). The mean WCRS score at baseline was 5.8 ± 3.4 in group A (where first 1 Hz rTMS and then sham was applied) and 13.4 ± 5.2 in group B (where first sham and then 1 Hz rTMS were applied). An inhibitory rTMS protocol applied to the left IPL resulted in a statistically significant improvement in the WCRS total score [WCRS difference real minus sham mean (SD): −1 (1.3), (95% confidence interval (CI): −2, −1), p = 0.002] and writing movement score [WMS mean difference (SD): −1 (1.4), CI: (−2, 0), p = 0.005], irrespective of the sequence in which they received the intervention. Secondary outcomes were similar between the groups.

CONCLUSION:
In patients with task-specific focal hand dystonia, a single session of rTMS to the left IPL resulted in a modest reduction of focal hand dystonia severity. The results serve as a proof-of-concept for future studies to assess the clinical effects of multiple sessions of left IPL inhibition to modulate the abnormally hyperexcitable premotor–parietal–putaminal circuitry in task-specific focal hand dystonia.
Therapeutic Putty-based Hand Strengthening Exercises to Improve Hand Function and Quality of Life in Patients with Chronic Rheumatoid Arthritis
Authors: Choudhry Dimple , Singh Harpreet , Yadav Joginder , Dev Savarna , Kalra Sheetal 
Published: August 2024

Context:Rheumatoid arthritis (RA) primarily affects the hands, leading to disabling joint abnormalities and reduced muscle strength, profoundly impacting hand function and overall quality of life (QOL).Aim:The aim of this study was to find the effect of therapeutic putty-based hand exercises on hand function and QOL in patients with chronic RA.Setting and Design:It was an experimental study conducted at the College of Physiotherapy, Pt. B.D. Sharma, PGIMS, Rohtak.Subjects and Methods:In this study, 206 chronic RA patients were randomly split into two groups. Group A (control) received conventional physiotherapy care including hot fomentation, joint protection advice, active exercises, and splinting. Group B (experimental) engaged in hand strengthening exercises with 85 g of therapeutic putty alongside conventional physiotherapy. Key outcomes assessed grip and key pinch strength, hand function (Short Form of the Score for the Assessment and Quantification of Chronic Rheumatic Affections of the Hands), and QOL (WHO-BREF) at baseline, 4th, 8th, and 12thweeks.Statistical Analysis:Effect of treatment comparison was done with one-way analysis of variance followed byposthocanalysis.Results:The experimental group showed superior outcomes for grip, key strength, and hand function (P= 0.000). Regarding the QOL, improvements were observed in the physical component at the 4thweek (P= 0.003) and in both the 8thand 12thweeks (P= 0.000). The psychological, social, and environmental components improved significantly in the 8thand 12thweeks (P< 0.005).Conclusion:A therapeutic putty-based strength training program as an addition to usual care is a worthwhile, low-cost intervention that helps improve function, disability, and QOL.
Implications of Countermovement Jump in Agility and Sprint Acceleration in Hockey Players
Authors: Tiwari Rahul , Kumar Harish 
Published: August 2024

Background:
The purpose of the study was to determine the relationship between the Kinematic parameter (Peak Velocity during Counter Movement Jump (CMJ)) with Agility Run and Short Sprint Acceleration Run.

Material and Method:
Total of 124 (66 males and 58 females) hockey trainees performed CMJ on Force Platform followed by 5-m short sprint acceleration and 6 m × 10 m shuttle run. Pearson’s correlation was calculated, and the level of significance was kept at P ≤ 0.05.

Results:
The correlation of peak velocity with short sprint acceleration run and agility run was found as r = −0.542 and r = −0.457, respectively, for all subjects, while male hockey trainees demonstrated the values of r = −0.794 and −0.699, whereas the female hockey trainees indicated the values of r = −0.632 and r = −0.575 with short sprint acceleration run and agility run, respectively.

Conclusion:
The present study concluded that peak velocity had a linear correlation with short sprint acceleration run as well as agility run. This could be a fruitful result for coaches as well as players to inculcate the vertical Jump regime in their training program so as to improve the performance of the players.
Spherical objects in dimensions two and three
Authors: Hara Wahei , Wemyss Michael 
Published: August 2024

This paper classifies spherical objects in various geometric settings in dimensions two and three, including both minimal and partial crepant resolutions of Kleinian singularities, as well as arbitrary flopping

3

-fold contractions with only Gorenstein terminal singularities. The main result is much more general: in each such setting, we prove that all objects in the associated null category

\mathcal{C}

with no negative Ext groups are the image, under the action of an appropriate braid or pure braid group, of some object in the heart of a bounded t-structure. The corollary is that all objects

x

which admit no negative Exts, and for which

\mathrm{Hom}_{\mathcal{C}}(x,x)=\mathbb{C}

, are the images of the simples. A variation on this argument goes further and classifies all bounded t-structures on

\mathcal{C}

. There are multiple geometric, topological and algebraic consequences, primarily to autoequivalences and stability conditions. Our main new technique also extends into representation theory, and we establish that in the derived category of a finite-dimensional algebra which is silting discrete, every object with no negative Ext groups lies in the heart of a bounded t-structure. As a consequence, every semibrick complex can be completed to a simple-minded collection.
Safety Assessment on Product E 401 (Sodium Alginate) Used as a Surface Treatment in Entire Fruits and Vegetables (RP290)
Authors:   Food Standards Agency,   Food Standards Scotland
Published: August 2024

An application was submitted to the Food Standards Agency (FSA) and Food Standards Scotland (FSS) in February 2021 from Bio Natural Solutions – BNS S.A.C. (‘the Applicant’) for the modification of the conditions of use of sodium alginate (CAS: 9005-38-3), which is an already authorised food additive (E 401), to the surface of entire fresh fruit and vegetables, as a coating to preserve them. The Applicant intends to extend the use of the sodium alginate (E 401) as a coating material within the food category: 4.1.1 ‘Entire fresh fruit and vegetables to include citrus fruit, melons, pineapples, bananas, papayas, mangoes, avocados, pomegranates’ at the level of quantum satis. To support the FSA and FSS in evaluating the dossier the Joint Expert Group on Additives, Enzymes and other regulated products (AEJEG) were asked to review the dossier and the supplementary information from the Applicant. The AEJEG concluded that no risk to health would be presented from this extension of use of E 401 on the basis that the additive was considered of low toxicological concern, as indicated by the European Food Standards Agency’s (EFSA) decision that a numerical ADI was not required. The Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) also reviewed the AEJEG safety assessment agreeing with the conclusions of the AEJEG. The views of the AEJEG and COT have been taken into account in this safety assessment which represents the opinion of the FSA and FSS on the extension of use of the sodium alginate (E 401) as a coating material in entire fresh fruit and vegetables.
Impact of Sperm Positioning and Aspiration Volume on Intracytoplasmic Sperm Injection (ICSI) Outcomes
Authors: TROSHINA TATIANA 
Published: August 2024

Objective To evaluate the influence of aspiration volume and final sperm position relative to the needle on fertilization and embryo development competence in ICSI. Methods A retrospective study analyzed 385 ICSI procedure videos, measuring distances between the needle bevel base and the sperm at oolemma breakage and needle withdrawal moments. Outcomes assessed were fertilization and blastulation rates. Results Blastulation rates did not significantly differ across aspiration volumes: <4 pl (50%), 4-8 pl (41.2%), 8-12 pl (47.2%), >12 pl (37.9%). Fertilization failure was higher (19.6%) when the sperm was near the needle bevel base at needle withdrawal compared to 2.4% when just behind the needle tip (p<0.0001). Fertilization rates were 66% with sperm in the needle trumpet vs. 85% outside (p=0.0017). Conclusions Blastulation rate was unaffected by aspiration volumes below 12 pl. Sperm positioned near the needle bevel base at withdrawal increased fertilization failure risk. Positioning sperm in the trumpet before withdrawal decreased fertilization rates. Further studies are needed to validate these findings across different settings.
Sedimentable Atmospheric Dust in Administrative Offices In the Districts of the Province of Leoncio Prado, Peru: A Diagnosis for the Fulfillment of the Objective of Sustainable Development-Health and Well-Being
Authors: Carbajal Geraldine Sanchez , Reategui-Inga Manuel , Durand Ronald Panduro , Coaguila-Rodriguez Peter , Aguirre-Escalante Casiano , Alvarado Víctor Beteta 
Published: August 2024

Objective: Evaluate the level of atmospheric settleable dust concentration in three administrative offices of six district municipalities in the province of Leoncio Prado, Huánuco; from May to October 2022.

Method: The methodology of passive sampling with receptor plates was employed, and the atmospheric settleable dust sampling equipment was placed in the administrative offices of civil registry, reception, and human resources.

Results: The civil registry administrative office of the Castillo Grande District Municipality recorded an average concentration of 1.121 mg/cm²/30 days. In the Pueblo Nuevo District Municipality, the civil registry office recorded 0.530 mg/cm²/30 days and the reception office recorded 0.539 mg/cm²/30 days. All of these exceed the maximum permissible limit established by the World Health Organization (WHO) (0.5 mg/cm²/30 days).

Contribution: This study will contribute to improving air quality and safeguarding the health of workers in these administrative offices affected by pollution, thereby ensuring a healthier work environment.
Exploring the Moderating Role of Perceived Supervisor support in the Effect of Employees’ Workplace Loneliness on Intention to Quit From the SDGS Perspective
Authors: Ongel Gokten , Taskiran Erkan , Celik Gulsah Gencer , Aydingun Gokhan 
Published: August 2024

Objective: The main purpose of this study is to investigate the moderating role of perceived supervisor support in the effect of workplace loneliness on intention to quit.

Theoretical Framework: The underpinning theories of this study is organizational support theory (OST) and social exchange theory (SET). This study focuses on decent work and economic growth goal, one of the Social Development Goals (SDGs), as it contains examining if the different work conditions due to the COVID 19 pandemic may cause different attitudes and behaviors.

Method: This study employs a survey technique, one of the quantitative research methods, on 200 employees working for a cruise tourism company. The collected data were analyzed using SPSS and SmartPLS statistical programs.

Results and Discussion: As a result of the findings, it was found that emotional deprivation has no effect on employees’ intention to quit while the lack of social companionship has positive and significant effect on intention to quit. In addition, it was determined that perceived supervisor support has a moderating effect on the association between emotional deprivation and intention to quit whereas no moderating role of perceived supervisor support on the relationship between lack of social companionship and intention to quit was found.

Originality/Value: This study contributes to the literature by testing the theories of OST and SET in terms of diferent sectoral characteristics in the business world. Questioning the theories of organizational support and social exchange widens the scope of related literature. While enriching the existing literature by conducting such a research, a new explanation has been provided for the associations between variables.
KEGIATAN PENCEGAHAN PERILAKU BERESIKO COVID 19 DI RW 005 DESA BAYONGBONG KECAMATAN BAYONGBONG KABUPATEN GARUT TAHUN 2021
Authors: Natasya Laila Yuanita , Ratna Hidayani Wuri 
Published: August 2024

Berdasarkan data yang dihimpun oleh Satuan Tugas Penanganan COVID-19 per tanggal 13 Oktober 2020, dari total kasus yang terkonfirmasi positif COVID-19, sebanyak 1.488 pasien tercatat memiliki penyakit penyerta. Di mana presentase terbanyak diantaranya penyakit hipertensi sebesar 50,5%, kemudian diikuti Diabetes Melitus 34,5% dan penyakit jantung 19,6%. Sementara dari jumlah 1.488 kasus pasien yang meninggal diketahui 13,2% dengan hipertensi, 11,6% dengan Diabetes Melitus serta 7,7% dengan penyakit jantung. Untuk itu, dalam rangka mendorong kesadaran masyarakat akan pentingnya upaya promotif preventif, Kementerian Kesehatan telah melakukan kegiatan monitoring dan skrining secara berkala dengan melibatkan peran serta masyarakat melalui Pos Binaan Terpadu (POSBINDU). Tujuan kegiatan ini adalah untuk mengetahui pelaksanaan dan evaluasi kegiatan pencegahan perilaku berisiko Covid 19.
Kegiatan ini dilaksanakan melalui kegiatan pengabdian masyarakat melalui pertemuan bersama kader, Sosialisasi Bersama Lurah Desa Bayongbong, Menyebarkan Media Leaflet dan Piring. Sasarannya adalah masyarakat RW 005 Desa Bayongbong Kecamatan Bayongbong Kabupaten Garut.
Hasil kegiatan ini adalah penyebaran media leaflet disebar secara digital. Respon positif dari sasaran ketika diberikan media (leaflet) menjadi sarana bagi masyarakat dalam peningkatan pengetahuan. Pembentukan kader anti penyakit Komobid, beranggotakan 5 orang kader di RW 05. Adanya kesadaran masyarakat dan tokoh masyarakat dalam mendukung perencanaan kegiatan yang dilakukan. Adanya apresiasi dari masyarakat ketika media pendukung piring berstiker dibagikan kepada masyarakat, menjadikan masyarakat lebih memahami dalam pengaturan pola makan khususnya bagi yang memiliki riwayat penyakit komorbid COVID-19.
Mengadakan penyuluhan secara kontinyu untuk lebih meningkatkan pemahaman serta kesadaran masyarakat terhadap penyakit komorbid dengan covid-19.
Making faces: Interferencias entre las Artes Plásticas y el Maquillaje
Authors: Alameda Galán Jesús 
Published: August 2024

Durante años he desarrollado mi investigación centrada en el cuerpo, un cuerpo editable, con capacidad de transmutación. Este juego de creación de personajes posibles se construye mediante maquillaje, prótesis o máscaras que otorgan al individuo otras lecturas y significados. En 2018 decido estudiar en una escuela profesional de maquillaje y caracterización. Esto me ayudó a entender la técnica de manera más profunda, lo que hizo que se expandieran las posibilidades creativas. Dicha formación me dio la oportunidad de trabajar en otros campos como el de la moda, la fotografía editorial o la publicidad. Dentro de estos campos profesionales pude reconocer ciertas interferencias entre los trabajos de maquillaje, que se estaban realizando en el mundo de la moda actual, con imágenes y conceptos que guardaba sobre referentes artísticos con los que ya había trabajado. Las imágenes que encontramos en la industria de la belleza actual parecen tener un discurso poético/estético que dificulta vislumbrar la línea de separación, si es que existe, entre las artes plásticas y la imagen comercial de un “Beauty”. La industria de la belleza se ha regido durante años en un plano canónico, poco permeable, pero al igual que los artistas de la vanguardia se preguntaron en cierto momento qué es arte, o en los años 70 la moda comienza a reinterpretar la funcionalidad y las formas de los patrones, los maquilladores y la industria de la moda se están preguntando qué es belleza, apareciendo un concepto expandido que va más allá de una finalidad estética, el maquillaje como una mera expresión artística. La reciente exposición de Gina Beavers “Face Painting” en el MoMa de Nueva York, la cantidad de artistas plásticos que se introducen dentro del mundo del maquillaje como Peter Philips, Isamaya French o Pat McGrath y la infinidad de publicaciones dedicadas a esta técnica artística como la de LyLe Xox, “Head of Design”, hacen que sea necesario el reconocimiento mediante una investigación que reflexione y recopile el papel del maquillaje en la actualidad, el papel del “Makeup Artist” y su vínculo con las artes plásticas. En este fotoensayo, ejemplificamos algunas de las interferencias encontradas durante la investigación, en ocasiones estas conexiones son solamente estéticas, otras conceptuales, otras a nivel técnico. En otros caso encontramos una reflexión completa en cuestión a un concepto ya creado por artistas plásticos a lo largo de la historia, en este fotoensayo se pretende diluir el tiempo y los movimientos artísticos en un espacio global de referencias donde todas estas interconectadas. En este caso solo encontramos una pequeña representación de la investigación, que casi a modo de juego nos introduce dentro del mundo del maquillaje en la actualidad.
Ökolandbau fördert genetische Vielfalt
Authors: Schaal René 
Published: August 2024

Frankfurt a.M. 23 Jahre lang hat ein Forschungsteam verglichen, ob sich konventionelle und ökologische Bewirtschaftungsformen darauf auswirken, wie sich die genetische Vielfalt von Gerste entwickelt. Die Analysen geben Hinweise, wie Züchter die Ertragslücke im Ökolandbau schließen könnten.
Alter Weizen in neuen Sorten
Authors: Schaal René 
Published: August 2024

Frankfurt a.M. Eine wissenschaftliche Analyse von alten Landrassen des Weizens hat gezeigt, welche nützlichen und bisher unbekannten Genvarianten in diesen Pflanzen stecken. Die Untersuchungen könnten helfen, vorteilhafte Merkmale gezielt in moderne Weizensorten einzukreuzen, um die Widerstandsfähigkeit dieser Kulturpflanze gegenüber Klimawandel und Krankheitserregern zu erhöhen.
Analisis Kepuasan Wali Murid Ditinjau Dari Kualitas Pelayanan, Keandalan Dan Daya Tanggap Guru Paud Hidayatul Mubtadi-Ien Purwokerto
Authors: Umi Hani  , Fitria Yuni Astuti  
Published: August 2024

Tujuan penelitian ini untuk meneliti analisis kepuasan wali murid ditinjau dari kualitas pelayanan, keandalan dan daya tanggap guru. Jenis penelitian adalah penelitian deskriptif kuantitatif. Subjek penelitian ini adalah wali murid PAUD Hidayatul Mubtadi-Ien Purwokerto sebanyak 31 responden dengan metode penelitian accidental sampling.
Hasil penelitian menunjukkan bahwa secara parsial kualitas pelayanan berpengaruh terhadap kepuasan wali murid dengan nilai thitung sebesar 1,751 > nilai ttabel 1,703, keandalan berpengaruh terhadap kepuasan wali murid dengan nilai thitung sebesar 2,630 > nilai ttabel 1,703, daya tanggap berpengaruh terhadap kepuasan wali murid dengan nilai thitung sebesar 3,108 > nilai ttabel 1,703, sedangkan secara simultan kualitas pelayanan, keandalan dan daya tanggap guru berpengaruh terhadap kepuasan wali murid dengan nilai Fhitung sebesar 7,422 > Ftabel sebesar 2,95. Koefisien determinasi dengan Adjusted R Square sebesar 0,391 yang menujukan bahwa 39,1%, kepuasan wali murid dipengaruhi oleh kualitas pelayanan, keandalan dan daya tanggap guru sedangkan sisanya sebesar 60,9% dijelaskan oleh variabel lain yang tidak di teliti dalam penelitian ini.
TEXT Reviews April 2020
Authors: Brown Ashley , Chowdhury Madhupriya Roy , Costello Moya , Gildfind HG , Gist Christopher , Henderson Alex , Hennessy Rachel , Hughes d' Aeth Tony , Linke Jayne , Mitra Zinia , Kampmark Nataša , Stewart Deb , Vernay JF , Walker Amelia 
Published: August 2024

Janelle Adsit (ed), Critical Creative Writing: Essential Readings on the Writer’s Craft review by Rachel Hennessy Maryanne Wolf, Reader, Come Home: The Reading Brain in a Digital World review by JF Vernay Ann M McCulloch and RA Goodrich (eds), Why Do Things Break? review by Nataša Kampmark Helen Garner, Yellow Notebook: Diaries volume 1 1978-1987 review by Moya Costello Andrew McGahan, The Rich Man’s House review by Nataša Kampmark Eugen Bacon, Claiming T-Mo review by Bronwyn Lovell Philip Salom, The Returns review by HC Gildfind Barrie Sherwood, The Angel Tiger and Other Stories review by Ashley Brown Kathleen Mary Fallon, A fixed place: the long and short of story review by Alex Henderson Colin Rogers, From the Mallee: Five Stories review by Christopher Gist Rachel Mann, A Kingdom of Love and Marjon Mossammaparast, That Sight review by Madhupriya Roy Chowdhury Christina Houen, This Place You Know review by Zinia Mitra Mary Pomfret, The Hard Seed review by Deb Stewart Owen Bullock, Summer Haiku review by Jayne Linke and Amelia Walker Glen Phillips, In the Hollow of the Land: Collected Poems 1968-2018 review by Tony Hughes-d’Aeth Charmaine Papertalk Green, Nganajungu Yagu review by Amelia Walker