bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain magnetic resonance imaging findings in patients with mucopolysaccharidosis VI
Authors: Azevedo Ana C. M. , Artigalás Osvaldo , Vedolin Leonardo , Komlós Márcia , Pires Adriana , Giugliani Roberto , Schwartz Ida Vanessa D. 
Published: November 2012

AbstractIntroductionMucopolysaccharidosis type VI (MPS VI) is a rare lysosomal storage disorder caused by the deficient activity of N‐acetylgalactosamine 4‐sulfatase. MPS VI is usually considered as not being associated with mental retardation.Aims/methodsThe main objective of the present study was to describe brain magnetic resonance imaging (MRI) findings and their correlation with clinical and biochemical findings in MPS VI patients. The study was conducted at Hospital de Clínicas de Porto Alegre, Brazil with 25 MPS VI patients. All patients were evaluated through clinical evaluation, IQ tests, urinary glycosaminoglycans (GAG) analysis, and brain MRI.ResultsMean age at evaluation was 10.6 ± 4.52 years. Five of 16 patients presented total IQ below the normal range. Brain MRI was abnormal in the majority of patients (n = 19/21), and the most frequent abnormalities found were the presence of dilated perivascular spaces and white matter lesions. Correlations were found between age and normalized white matter lesion load (NLL) (r = 0.46; p = 0.04) and normalized cerebral volume (NCV) (r = −0.56; p = 0.01), between NLL and height deficit (r = 0.48; p = 0.04), and between NCV and weight deficit (r = −0.58; p = 0.01) and height deficit (r = −0.55; p = 0.01). A correlation between urinary GAG levels and quantitative brain MRI findings was not found, neither between qualitative and quantitative brain MRI findings and IQ scores.ConclusionsMPS VI patients may present abnormal IQ scores without correlation with brain abnormalities on the MRI, a finding which was found to be very frequent in MPS VI. Additional studies are required to confirm our findings.
Evaluating the Transferability of FT‐NIR Calibration Models for Fatty Acid Determination of Edible Fats and Oils Among Five Same‐make Spectrometers Using Transmission or Transflection Modes with Different Pathlengths
Authors: Azizian Hormoz , Kramer John K. G. , Mossoba Magdi M. 
Published: November 2012

AbstractFourier transform near‐infrared (FT‐NIR) spectroscopy in conjunction with partial least squares 1 (PLS1) calibration models was previously reported to be an alternative method to GC for the rapid determination of the fatty acid (FA) composition of fats and oils. These calibration models had been developed based on accurate GC data (primary reference method) and observed FT‐NIR spectra. In the present three‐laboratory limited collaborative study, the transferability of these pre‐developed calibration models to four other FT‐NIR spectrometers from the same manufacturer was evaluated. Six samples were selected that provided a wide range of FA contents. Our results indicate that these models were successfully transferable to spectrometers operating in the transflection mode with 2‐ or 4‐mm pathlength fiber optic probes or in the transmission mode using 5‐mm, but not 8‐mm, outer diameter tubes. The predicted FA composition fell within the statistically accepted limits of agreement between FT‐NIR and GC. The FT‐NIR precision data were consistent with those reported in a published GC collaborative study. The application of FT‐NIR to the determination of the total content of SFA, trans FA, MUFA, and PUFA is cost‐effective and potentially suitable for the rapid screening of commercial products for compliance verification with labeling regulations.
Thermal Degradation Kinetics of Carotenoids in Palm Oil
Authors: Sampaio Klicia A. , Ayala Jose V. , Silva Simone M. , Ceriani Roberta , Verhé Roland , Meirelles Antonio J. A. 
Published: November 2012

AbstractIn the present work, a detailed study is performed for carotene thermal degradation in palm oil at four temperatures ranging from 170 to 230 °C. The heating process was carried out with injection of nitrogen, and the samples were collected every 20 min during a total heating period of 140 min. HPLC analysis was conducted to monitor the carotenoids and tocols variations over the heating time at each temperature. The experimental data were then compared to literature data concerning carotenoids thermal degradation. The thermal degradation kinetics of carotenoids in palm oil followed an order superior to 1. The dependence of constant rates with temperature obeyed the Arrhenius relationship. The activation energy for the carotenoids thermal degradation in palm oil was found to be 109.4 kJ/mol.
Clinical Issues
Authors: Woods Kathleen D. 
Published: November 2012

This MonthInformed consent for repeated proceduresKey words: informed consent, sequential procedures, serial procedures, repeat procedures, power of attorney.Obtaining informed consent after administration of preoperative sedationKey words: informed consent, surgical consent, preoperative sedation.Use of medical scribes in perioperative servicesKey words: medical scribes, clinical information managers, health care worker.
Results of the 2012 AORN Salary and Compensation Survey
Authors: Bacon Donald R. 
Published: November 2012

AbstractAORN conducted its 10th annual compensation survey for perioperative nurses in June 2012. A multiple regression model was used to examine how a number of variables, including job title, education level, certification, experience, and geographic region, affect nurse compensation. Comparisons between the 2012 data and previous years’ data are presented. The effects of other forms of compensation, such as on‐call compensation, overtime, bonuses, and shift differentials on base compensation rates, also are examined. Additional analyses explore the effect of the current economic downturn on the perioperative work environment.
Perioperative Employee Annual Evaluations: A 30‐Second Process
Authors: Olmstead John , Falcone Deborah , Lopez Jacy , Sharpe Lorraine , Michna Jody 
Published: November 2012

AbstractIn response to complaints about the annual evaluation tool used at The Community Hospital in Munster, Indiana, the surgical services management team created a tool to rate the perioperative RNs on skills pertinent to the surgical services department. The hospital‐wide evaluation tool uses vague criteria, which are regularly challenged by employees who disagree with their manager's evaluation. The new Surgical Services Employee Evaluation takes a manager approximately 30 seconds to complete and can be added to the generic hospital evaluation form to make the employee evaluation more accurate and meaningful. The tool evaluates three major categories: teamwork, patient care, and job preparation. Use of this additional tool has greatly reduced postevaluation employee complaints, and the tool is now being used in other departments, with slight department‐specific variations. Employees now express less frustration with annual evaluations, and managers report a high degree of satisfaction with the tool because it helps them in the difficult task of employee evaluation and counseling.
Amyloid positron emission tomography with 18F‐flutemetamol and structural magnetic resonance imaging in the classification of mild cognitive impairment and Alzheimer's disease
Authors: Duara Ranjan , Loewenstein David A. , Shen Qian , Barker Warren , Potter Elizabeth , Varon Daniel , Heurlin Kristen , Vandenberghe Rik , Buckley Christopher 
Published: November 2012

AbstractObjectiveTo evaluate the contributions of amyloid‐positive (Am+) and medial temporal atrophy–positive (MTA+) scans to the diagnostic classification of prodromal and probable Alzheimer's disease (AD).Methods18F‐flutemetamol‐labeled amyloid positron emission tomography (PET) and magnetic resonance imaging (MRI) were used to classify 10 young normal, 15 elderly normal, 20 amnestic mild cognitive impairment (aMCI), and 27 AD subjects. MTA+ status was determined using a cut point derived from a previous study, and Am+ status was determined using a conservative and liberal cut point.ResultsThe rates of MRI scans with positive results among young normal, elderly normal, aMCI, and AD subjects were 0%, 20%, 75%, and 82%, respectively. Using conservative cut points, the rates of Am+ scans for these same groups of subjects were 0%, 7%, 50%, and 93%, respectively, with the aMCI group showing the largest discrepancy between Am+ and MTA+ scans. Among aMCI cases, 80% of Am+ subjects were also MTA+, and 70% of amyloid‐negative (Am−) subjects were MTA+. The combination of amyloid PET and MTA data was additive, with an overall correct classification rate for aMCI of 86%, when a liberal cut point (standard uptake value ratio = 1.4) was used for amyloid positivity.Interpretation18F‐flutemetamol PET and structural MRI provided additive information in the diagnostic classification of aMCI subjects, suggesting an amyloid‐independent neurodegenerative component among aMCI subjects in this sample.
Impact of molecular imaging on the diagnostic process in a memory clinic
Authors: Ossenkoppele Rik , Prins Niels D. , Pijnenburg Yolande A.L. , Lemstra Afina W. , van der Flier Wiesje M. , Adriaanse Sofie F. , Windhorst Albert D. , Handels Ron L.H. , Wolfs Claire A.G. , Aalten Pauline , Verhey Frans R.J. , Verbeek Marcel M. , van Buchem Mark A. , Hoekstra Otto S. , Lammertsma Adriaan A. , Scheltens Philip , van Berckel Bart N.M. 
Published: November 2012

AbstractBackground[11C]Pittsburgh compound B ([11C]PIB) and [18F]‐2‐fluoro‐2‐deoxy‐D‐glucose ([18F]FDG) PET measure fibrillar amyloid‐β load and glucose metabolism, respectively. We evaluated the impact of these tracers on the diagnostic process in a memory clinic population.MethodsOne hundred fifty‐four patients underwent paired dynamic [11C]PIB and static [18F]FDG PET scans shortly after completing a standard dementia screening. Two‐year clinical follow‐up data were available for 39 patients. Parametric PET images were assessed visually and results were reported to the neurologists responsible for the initial diagnosis. Outcome measures were (change in) clinical diagnosis and confidence in that diagnosis before and after disclosing PET results.Results[11C]PIB scans were positive in 40 of 66 (61%) patients with a clinical diagnosis of Alzheimer's disease (AD), 5 of 18 (28%) patients with frontotemporal dementia (FTD), 4 of 5 (80%) patients with Lewy body dementia, and 3 of 10 (30%) patients with other dementias. [18F]FDG uptake patterns matched the clinical diagnosis in 38 of 66 (58%) of AD patients, and in 6 of 18 (33%) FTD patients. PET results led to a change in diagnosis in 35 (23%) patients. This only occurred when prior diagnostic certainty was <90%. Diagnostic confidence increased from 71 ± 17% before to 87 ± 16% after PET (p < .001). Two‐year clinical follow‐up (n = 39) showed that [11C]PIB and [18F]FDG predicted progression to AD for patients with mild cognitive impairment, and that the diagnosis of dementia established after PET remained unchanged in 96% of patients.ConclusionsIn a memory clinic setting, combined [11C]PIB and [18F]FDG PET are of additional value on top of the standard diagnostic work‐up, especially when prior diagnostic confidence is low.
Three‐dimensional electroanatomical mapping for atrioventricular nodal reentrant tachycardia associated with persistent left superior vena cava
Authors: Nakamura Tomofumi , Hachiya Hitoshi , Suzuki Masahito , Sugiyama Koji , Yagishita Atsuhiko , Tanaka Yasuaki , Kawabata Mihoko , Sasano Tetsuo , Isobe Mitsuaki , Hirao Kenzo 
Published: November 2012

AbstractBackgroundThe anatomical courses of the slow pathway and His bundle are altered in patients with atrioventricular nodal reentrant tachycardia (AVNRT) associated with persistent left superior vena cava (PLSVC). We report a case of successful catheter ablation in such a patient using an electroanatomical approach with a three‐dimensional mapping system.CaseA 33‐year‐old woman underwent catheter ablation for AVNRT. The conventional approach for ablating the atrial end of the slow pathway was unsuccessful; therefore, a second attempt was made using a three‐dimensional electroanatomical mapping system. The ablation was easily performed without damaging the His bundle because of a clear understanding of the anatomical relationships.ConclusionThe electroanatomical approach using a three‐dimensional mapping system can be an alternative if conventional methods prove to be technically difficult because this new approach can provide precise spatial distribution of the pathways.
Migration paths of magma and fluids and lava compositions in Kamchatka
Authors: Dobretsov N.L. , Koulakov I.Yu. , Litasov Yu.D. 
Published: November 2012

AbstractGeophysical and geochemical data have been analyzed jointly in order to gain better understanding of subduction-related active volcanism in Kamchatka. The velocity structure of lithosphere beneath volcanic arcs has been imaged on three scales. Regional tomography to distances of thousands of kilometers has allowed constraints on slab geometry, which changes markedly in dip angle and thickness beneath the Kuriles-Kamchatka arc, possibly, because of a change in the interplay of the subduction driving forces. Intermediate-scale regional tomography (hundreds of kilometers) has been applied to the cases of Toba caldera in Sumatra, Mount Merapi in Java, and volcanoes in the Central Andes and provided evidence of magma conduits marked by low-velocity zones that link the suprasubduction volcanic arcs with clusters of earthquake hypocenters on the slab top. Local tomography resolves the shallow structure immediately under volcanoes and the geometry of respective melting zones. An example time-lapse (4D) seismic model of the crust beneath the Klyuchevskoy group of volcanoes has imaged a decade-long history of anomalous velocity zones and their relation with the activity cycles of Bezymyanny and Klyuchevskoy volcanoes. As modeling shows, andesitic Bezymyanny and basaltic Klyuchevskoy volcanoes have different feeding patterns during their eruption cycles: the former feeds directly from the mantle while the material coming to the latter passes through a complicated system of intermediate chambers.The local tomography model has been applied as reference to interpret the available major- and trace-element data from the Klyuchevskoy and Bezymyanny volcanoes. The lava compositions of the two volcanoes have becoming ever more proximal since 1945 in many major and trace elements while some parameters remain different. Paroxysmal eruptions of Bezymyanny for several recent decades correlate with the time when Klyuchevskoy erupted lavas with high percentages of high-Mg basalts. The difference in the evolution trends of the Kamchatka volcanic rocks may be due either to fractional crystallization or to the presence of concentrator minerals in the source, titanomagnetite, orthopyroxene, rutile, garnet, and plagioclase being especially active as to uptake of some elements. The natural compositions of rocks have been compared in this context with published experimental data.According to the seismic velocity structure and lava compositions analyzed jointly, there are five levels of crystallization beneath the studied volcanoes, while the number and spatial patterns of magma sources are different for two types of andesitic volcanoes.
Concentration of trace elements in small lakes of the Ingoda basin (Chita Region, Russia)
Authors: Sklyarova O.A. , Sklyarov E.V. , Menshagin Yu.V. 
Published: November 2012

Abstract
By the example of the Ingoda basin (Transbaikalia) including a system of small lakes, the role of two leading processes of concentration of trace elements in small reservoirs (water–rock interaction and evaporation) has been estimated. It is shown that the accumulation of U, As, Se, Sb, and Ge does not depend on the kind of concentration. Their contents increase linearly with total dissolved solids in both lake and feeding waters. Accumulation of Sc, V, Y, Th, REE, and W is mainly due to evaporation, with their maximum concentration by three to four orders of magnitude. Only U, W, and REE, whose contents in the lakes reach n⋅100 μg/L, are of practical interest.
A relationship between the source of the 25 May 1887 earthquake and the fault along the Biliktuika River valley (southern Siberian Platform)
Authors: Gladkov A.S. , Radziminovich Ya.B. , Lunina O.V. 
Published: November 2012

AbstractSeveral active fault zones were studied in the southern Siberian Platform along the Kovykta–Sayansk–Irkutsk gas pipeline. Late Cenozoic seismogenic faults are observed here. The fault zone in the Biliktuika River valley shows the strongest displacements and deformations. The radiocarbon dating of buried soil horizons for this fault was compared with seismological data on the earthquakes observed in this area. The comparison permitted attributing the latest slip along the fault to the 25 May 1887 earthquake.
Nasal tip abscess due to adverse skin reaction to Prolene: an unusual long term complication of rhinoplasty
Authors: Teymoortash A , Fasunla J A , Pfützner W , Steinbach-Hundt S 
Published: November 2012

AbstractObjectives:Allergic reactions to Prolene are rare. This paper reports a nasal tip abscess which developed in a patient with an adverse skin reaction to Prolene after rhinoplasty.Methods and results:A 26-year-old woman presented with painful, progressive nasal tip swelling and redness. She had undergone septo-rhinoplasty two years previously. She was initially treated with endonasal drainage of the abscess and antibiotics, but a revision rhinoplasty three months later became necessary because of recurrent abscess formation. Intra-operative findings included granulation tissue with pockets of pus and knotted Prolene sutures at the tip-defining points of the lower lateral cartilages. She was patch-tested with Prolene and a cutaneous Prolene suture was placed on her back; an adverse skin reaction was seen for the latter.Conclusion:Use of non-absorbable sutures, such as Prolene, in the subcutaneous layer may be a potential, rare risk factor for adverse skin reactions.
Connexin 26 and 30 mutations in paediatric patients with congenital, non-syndromic hearing loss treated with cochlear implantation in Mediterranean Turkey
Authors: Tarkan Ö , Sari P , Demirhan O , Kiroğlu M , Tuncer Ü , Sürmelioğlu Ö , Özdemir S , Yilmaz M B , Kara K 
Published: November 2012

AbstractObjective:Mutations in the genes for connexin 26 (GJB2) and connexin 30 (GJB6) play an important role in autosomal recessive, non-syndromic hearing loss. This study aimed to detect the 35delG and 167delT mutations of theGJB2gene and the del(GJB6-D13S1830) mutation of theGJB6gene in paediatric patients diagnosed with congenital, non-syndromic hearing loss and treated with cochlear implantation in Mediterranean Turkey.Materials and method:We included 94 children diagnosed with congenital, non-syndromic hearing loss and treated with cochlear implantation. Blood samples were collected, DNA extracted and an enzyme-linked immunosorbent assay performed to enable molecular diagnosis of mutations.Results:Of the 94 children analysed, the 35delG mutation was detected in 12 (12.7 per cent): 10 (83.3 per cent) were homozygous and 2 (16.7 per cent) heterozygous mutant. The 167delT and del(GJB6-D13S1830) mutations were not detected.Conclusion:The GJB2-35delG mutation is a major cause of congenital, non-syndromic hearing loss in this study population.
Lead and wine. Eberhard Gockel and the colica Pictonum
Authors: Eisinger Josef 
Published: November 2012

AbstractThecolica Pictonum or colic of Poitou, under these and many other names, was a frequent, widespread, and deadly disease from Roman times until the eighteenth century. Its unique pathognomonic, notably a severe colic succeeded by paralysis and other central nervous system dysfunction, makes it possible to identify the disease with certainty as chronic lead disease, usually caused by the ingestion of lead-adulterated wines. The custom of sweetening and preserving sour wines with lead-containing additives is traced to the Romans. They had made the empirical discovery that sapa, a syrup prepared by concentrating must in a lead vessel, kept wine from spoiling and that it had, moreover, an agreeable flavour.Reports of outbreaks of the colica Pictonum appear in the medical literature from Roman times, but the correct aetiology of the disease was not discovered until the seventeenth century following a series of outbreaks in Southern Germany which were related to unfavourable climatic and political conditions. The connexion between the disease and prevailing methods for “correcting” wines was drawn in 1696 by Eberhard Gockel, then the city physician of Ulm. This achievement can be traced to his familiarity with Samuel Stockhausen's work on plumbism among miners and potters, as well as to the favourable epidemiological situation presented by Gockel's monastic patients.From the literary evidence assembled here and from experimental determinations of the lead content of sapa and similar concentrates, it is possible to estimate the lead levels and toxicity of wines from various eras. The levels range up to 80 mg/l and make it apparent that many wines were sufficiently toxic to account for the incidence and severity of the colica Pictonum. Explanations for the disastrous persistence of the colic of Poitou are discussed, as are the similarities between Gockel's approach and the methods of modern environmental medicine.
Fixed-choice word-association tasks as second-language lexical tests: What native-speaker performance reveals about their potential weaknesses
Authors: DRONJIC VEDRAN , HELMS-PARK RENA 
Published: November 2012

ABSTRACTQian and Schedl's Depth of Vocabulary Knowledge Test was administered to 31 native-speaker undergraduates under an “unconstrained” condition, in which the number of responses to headwords was unfixed, whereas a corresponding group (n = 36) completed the test under the original “constrained” condition. Results revealed lower accuracy in the unconstrained condition and in paradigmatic versus syntagmatic responses. Native speakers failed to reach the 90% criterion on most unconstrained and many constrained items. Although certain modifications could improve such a test (e.g., eliminating psycholinguistically anomalous headwords, such as adjectives, or presenting responses to headwords discontinuously), two intransigent problems impede test validity. First, collocates in the mental lexicon differ in tightness and vary across dialects, sociolects, and age groups. Second, it is more serious that second-language Depth of Vocabulary Knowledge Tests are likely spot checks of metalinguistic knowledge rather than depth tests that reflect what learners would actually produce in spontaneous utterances.
Durational cues to word recognition in spoken French
Authors: SHOEMAKER ELLENOR 
Published: November 2012

ABSTRACTIn spoken French, the phonological processes of liaison and resyllabification can render word and syllable boundaries ambiguous (e.g.,un air“an air”/un nerf“a nerve,” both [.nɛʁ]). Production data have demonstrated that speakers of French vary the duration of consonants that surface in liaison environments relative to consonants produced word initially. Further research has suggested that listeners exploit these durational differences in the processing of running speech, although no study to date has directly tested this hypothesis. The current study examines the exploitation of duration in word recognition processes by manipulating this single acoustic factor while holding all other factors in the signal constant. The pivotal consonants in potentially ambiguous French sequences (e.g., /n/ inun nerf) were instrumentally shortened and lengthened and presented to listeners in two behavioral tasks. The results suggest that listeners are sensitive to segmental duration and use this information to modulate the lexical interpretation of spoken French.