bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of comorbidity scores on re-operations following primary total hip replacement
Authors: Gordon M. , Stark A. , Sköldenberg O. G. , Kärrholm J. , Garellick G. 
Published: August 2013

While an increasing amount of arthroplasty articles report comorbidity measures, none have been validated for outcomes. In this study, we compared commonly used International Classification of Diseases-based comorbidity measures with re-operation rates after total hip replacement (THR). Scores used included the Charlson, the Royal College of Surgeons Charlson, and the Elixhauser comorbidity score. We identified a nationwide cohort of 134 423 THRs from the Swedish Hip Arthroplasty Register. Re-operations were registered post-operatively for up to 12 years. The hazard ratio was estimated by Cox’s proportional hazards regression, and we used C-statistics to assess each measure’s ability to predict re-operation. Confounding variables were age, gender, type of implant fixation, hospital category, hospital implant volume and year of surgery. In the first two years only the Elixhauser score showed any significant relationship with increased risk of re-operation, with increased scores for both one to two and three or more comorbidities. However, the predictive C-statistic in this period for the Elixhauser score was poor (0.52). None of the measures proved to be of any value between two and 12 years. They might be of value in large cohort or registry studies, but not for the individual patient. Cite this article: Bone Joint J 2013;95-B:1184–91.
Total hip replacement for developmental dysplasia of the hip with more than 30% lateral uncoverage of uncemented acetabular components
Authors: Li H. , Mao Y. , Oni J. K. , Dai K. , Zhu Z. 
Published: August 2013

In developmental dysplasia of the hip (DDH), a bone defect is often observed superior to the acetabulum after the reconstruction at the level of the true acetabulum during total hip replacement (THR). However, the essential amount of uncemented acetabular component coverage required for a satisfactory outcome remains controversial. The purpose of this study was to assess the stability and function of acetabular components with a lack of coverage > 30% (31% to 50%). A total of 760 DDH patients underwent THR with acetabular reconstruction at the level of the true floor. Lack of coverage above the acetabular component of > 30% occurred in 56 patients. Intra-operatively, autogenous morcellised bone grafts were used to fill the uncovered portion. Other than two screws inserted through the acetabular shell, no additional structural supports were used in these hips. In all, four patients were lost to follow-up. Therefore, 52 patients (52 hips, 41 women and 11 men) with a mean age of 60.1 years (42 to 78) were available for this study at a mean of 4.8 years (3 to 7). There were no instances of prosthesis revision or marked loosening during the follow-up. The Harris hip score improved from a mean of 40.7 points (sd 12.2) pre-operatively to 91.1 (sd 5.0) at the last follow-up. Radiological analysis with medical imaging software allowed us to calculate the extent of the uncoverage in terms of the uncovered arc of the implant as viewed on the anteroposterior pelvic radiograph. From this we propose that up to 17 mm of lateral undercoverage in the presence of a stable initial implantation in the presence of bone autografting, with an inclination angle of the acetabular component between 40° and 55°, is acceptable. This represents undercoverage of ≤ 50%.Cite this article: Bone Joint J 2013;95-B:1178–83.
Hemicortical resection and reconstruction using pasteurised autograft for parosteal osteosarcoma of the distal femur
Authors: Liu T. , Liu Z-Y. , Zhang Q. , Zhang X-S. 
Published: August 2013

The aim of this study was to assess a specific protocol for the treatment of patients with a parosteal osteosarcoma of the distal femur with limb salvage involving hemicortical resection and reconstruction using recycled pasteurised autograft and internal fixation. Between January 2000 and January 2010, 13 patients with a mean age of 26.5 years (17 to 39) underwent this procedure. All the tumours were staged according to Enneking’s criteria: there were eight stage IA tumours and five stage IB tumours. The mean follow-up was 101.6 months (58 to 142), and mean post-operative Musculoskeletal Tumour Society functional score was 88.6% (80% to 100%) at the final follow-up. All the patients had achieved bony union; the mean time to union was 11.2 months (6 to 18). Local recurrence occurred in one patient 27 months post-operatively. No patient had a pulmonary metastasis.A hemicortical procedure for the treatment of a parosteal osteosarcoma is safe and effective. Precise pre-operative planning using MRI is essential in order to define the margins of resection. Although it is a technically demanding procedure, gratifying results make it worthwhile for selected patients.Cite this article: Bone Joint J 2013;95-B:1275–9.
Femoral head deformity and severity of acetabular dysplasia of the hip
Authors: Okano K. , Yamaguchi K. , Ninomiya Y. , Matsubayashi S. , Osaki M. , Takahashi K. 
Published: August 2013

Patients with acetabular dysplasia commonly undergo peri-acetabular osteotomy after skeletal maturity to reduce the risk of the late development of osteoarthritis. Several studies have suggested that deformity of the femoral head influences the long-term outcome. We radiologically examined 224 hips in 112 patients with acetabular dysplasia and early-stage osteoarthritis. There were 103 women and nine men with a mean age of 37.6 years (18 to 49). A total of 201 hips were placed in the acetabular dysplasia group and 23 in a normal group. The centre–edge angle and acetabular head index were significantly smaller (both p < 0.001), and the acetabular angle, acetabular roof angle and roundness index were significantly greater in the acetabular dysplasia group than those in the normal group (all p < 0.001). There were significant correlations between the roundness index and other parameters. Femoral head shape may be influenced by the severity of the acetabular dysplasia.Cite this article: Bone Joint J 2013;95-B:1192–6.
Supracondylar humeral fractures in children
Authors: Lim K. B. L. , Lim C. T. , Tawng D. K. 
Published: August 2013

Supracondylar humeral fractures are common in children, but there are no classification systems or radiological parameters that predict the likelihood of having to perform an open reduction. In a retrospective case–control study we evaluated the use of the medial spike angle and fracture tip–skin distance to predict the mode of reduction (closed or open) and the operating time in fractures with posterolateral displacement. A total of 21 patients (4.35%) with a small medial spike angle (< 45°) were identified from a total of 494 patients, and 42 patients with a medial spike angle of > 45° were randomly selected as controls. The medial spike group had significantly smaller fracture tip–skin distances (p < 0.001), longer operating times (p = 0.004) and more complications (p = 0.033) than the control group. There was no significant difference in the mode of reduction and a composite outcome measure. After adjustments for age and gender, only fracture tip–skin distance remained significantly associated with the operating time (β = -0.724, p = 0.042) and composite outcome (OR 0.863 (95% confidence interval 0.746 to 0.998); p = 0.048).Paediatric orthopaedic surgeons should have a lower threshold for open reduction when treating patients with a small medial spike angle and a small fracture tip–skin distance.Cite this article: Bone Joint J 2013;95-B:1290–4.
Ultrastructural characteristics of the vitellarium of Brandesia turgida (Brandes, 1888) (Digenea: Pleurogenidae) and an examination of the potential usefulness of such vitelline traits in digenean systematics
Authors: Poddubnaya L. , Bruňanská M. , Brázová T. , Zhokhov A. , Gibson D. 
Published: August 2013

Abstract
Transmission electron microscopical observations were made on the vitelline structure of the digenean Brandesia turgida (Brandes, 1888) collected from crypts within the intestinal wall of the frog Pelophylax ridibundus (Pallas, 1771). Ultrastructural details of the vitelline follicles of B. turgida include: (a) the presence within the vitellarium of a single type of cell, i.e. vitellocytes at different stages of their development; (b) a narrow region between the vitellocytes filled with the processes of surrounding parenchymal cells; and (c) the occurrence of the junctional complexes between the vitellocytes and the surrounding parenchymal cells at the periphery of the vitelline follicles. It is shown that the vitelline globules and a few lipid droplets are the main inclusions resulting from vitellocyte synthetic activity. The limited amount of nutritive reserves in the vitellocytes can be explained by the nature of the parasite’s life-cycle, which is characterized by fully-embryonated intrauterine eggs containing a fully-formed miracidium. Despite the small number of digenean species studied in relation to their vitelline cytoarchitecture, two structural patterns of the vitellarium can be elucidated; these are examined in terms of digenean systematic relationships.
April 2013 Book Reviews
Authors: Neumann Donald 
Published: August 2013

JOSPT offers invited reviews of current titles. The April 2013 column includes 5 reviews of the following books: Diagnosis for Physical Therapists: A Symptom-Based Approach; FIMS Sports Medicine Manual: Event Planning and Emergency Care; Brunnstrom's Clinical Kinesiology: 6th Edition; Atlas of Anatomy: 2nd Edition; and Anatomy & Physiology Revealed. J Orthop Sports Phys Ther 2013;43(4):276–279. doi:10.2519/jospt.2013.43.4.276
Early treatment of coronal synostosis with endoscopy-assisted craniectomy and postoperative cranial orthosis therapy: 16-year experience
Authors: Jimenez David F. , Barone Constance M. 
Published: August 2013

Object
The objective of this study was to present the authors' 16-year experience treating coronal craniosynostosis in infants using endoscopy-assisted techniques and postoperative cranial orthoses.

Methods
A total of 128 synostosed coronal sutures in 115 patients were treated between 1996 and 2012 by endoscopically resecting a strip of bone containing the stenosed suture via a 2–3 cm incision made at the ipsilateral stephanion. Data were obtained from a prospective database. Following surgery, patients were fitted with custom cranial orthoses to help correct preoperative craniofacial deformities. All patients were followed closely with cranial anthropometric measurements and photographs.

Results
The estimated mean blood loss was 20 ml (range 5–120 ml) and the estimated mean strip size was 0.6 cm × 10.7 cm. The mean surgical duration was 55 minutes (range 22–150 minutes). One patient underwent an intraoperative blood transfusion and 1 had a postoperative blood transfusion, for a total transfusion rate of 1.7%. Ninety-seven percent of patients were discharged on the first postoperative day. There were no deaths. Vertical dystopia correction of more than 80% from baseline was obtained in almost two-thirds of patients, with 51% achieving 100% correction. Nasal and sagittal craniofacial deviation (vertex-nasion-gnathion) correction greater than 80% was achieved in 80% of patients, with 77% achieving 100% correction. Supraorbital rim advancement of the ipsilateral eye was obtained in 98% of cases, with correction of frontal plagiocephaly the last deformity to achieve correction.

Conclusions
Early treatment of coronal synostosis with endoscopy-assisted craniectomy and postoperative molding helmets leads to significant correction of craniofacial abnormalities, including vertical dystopia, nasal deviation, sagittal misalignment, and ipsilateral proptosis. This treatment method is associated with minimal trauma, blood loss, and transfusion rates, and typically only requires 1 overnight stay. This surgical approach is safe, effective, and associated with excellent results.
Distribution of cerebellar tonsil position: implications for understanding Chiari malformation
Authors: Smith Brandon W. , Strahle Jennifer , Bapuraj J. Rajiv , Muraszko Karin M. , Garton Hugh J. L. , Maher Cormac O. 
Published: August 2013

Object
Prior attempts to define normal cerebellar tonsil position have been limited by small numbers of patients precluding analysis of normal distribution by age group. The authors' objective in the present study was to analyze cerebellar tonsil location in every age range.

Methods
Two thousand four hundred patients were randomly selected from a database of 62,533 consecutive patients undergoing MRI and were organized into 8 age groups. Magnetic resonance images were directly examined for tonsil location, morphology, and other features. Patients with a history or imaging findings of posterior fossa abnormalities unrelated to Chiari malformation (CM) were excluded from analysis. The caudal extent of the cerebellar tonsils was measured at the midsagittal and lowest parasagittal positions.

Results
The mean tonsil height decreased slightly with advancing age into young adulthood and increased with advancing age in the adult age range. An increasing age in the adult age range was associated with a decreased likelihood of a tonsil position 5 mm or more below the foramen magnum (p = 0.0004). In general, the lowest tonsil position in each age group was normally distributed. Patients with pegged morphology were more likely to have a tonsil location at least 5 mm below the foramen magnum (85%), as compared with those having intermediate (38%) or rounded (2%) morphology (p < 0.0001). Female sex was associated with a lower mean tonsil position (p < 0.0001). Patients with a lower tonsil position also tended to have an asymmetrical tonsil position, usually lower on the right (p < 0.0001).

Conclusions
Cerebellar tonsil position follows an essentially normal distribution and varies significantly by age. This finding has implications for advancing our understanding of CM.
Expansion of CD133-positive glioma cells in recurrent de novo glioblastomas after radiotherapy and chemotherapy
Authors: Tamura Kaoru , Aoyagi Masaru , Ando Noboru , Ogishima Takahiro , Wakimoto Hiroaki , Yamamoto Masaaki , Ohno Kikuo 
Published: August 2013

Object
Recent evidence suggests that a glioma stem cell subpopulation may determine the biological behavior of tumors, including resistance to therapy. To investigate this hypothesis, the authors examined varying grades of gliomas for stem cell marker expressions and histopathological changes between primary and recurrent tumors.

Methods
Tumor samples were collected during surgery from 70 patients with varying grades of gliomas (Grade II in 12 patients, Grade III in 16, and Grade IV in 42) prior to any adjuvant treatment. The samples were subjected to immunohistochemistry for MIB-1, factor VIII, GFAP, and stem cell markers (CD133 and nestin). Histopathological changes were compared between primary and recurrent tumors in 31 patients after radiation treatment and chemotherapy, including high-dose irradiation with additional stereotactic radiosurgery.

Results
CD133 expression on glioma cells was confined to de novo glioblastomas but was not observed in lower-grade gliomas. In de novo glioblastomas, the mean percentage of CD133-positive glioma cells in sections obtained at recurrence was 12.2% ± 10.3%, which was significantly higher than that obtained at the primary surgery (1.08% ± 1.78%). CD133 and Ki 67 dual-positive glioma cells were significantly increased in recurrent de novo glioblastomas as compared with those in primary tumors (14.5% ± 6.67% vs 2.16% ± 2.60%, respectively). In contrast, secondary glioblastomas rarely expressed CD133 antigen even after malignant progression following radiotherapy and chemotherapy.

Conclusions
The authors' results indicate that CD133-positive glioma stem cells could survive, change to a proliferative cancer stem cell phenotype, and cause recurrence in cases with de novo glioblastomas after radiotherapy and chemotherapy.
La céramique commune à Marseille au XVIIe siècle : l'exemple de dépotoirs domestiques du site de la Charité
Authors: Abel Véronique 
Published: August 2013

La fouille d'urgence effectuée en 1983 dans la cour de l'ancien hôpital de la Charité à Marseille fut à l'origine de cette première recherche sur les céramiques utilisées dans cette cité aux époques modernes.
Deux dépotoirs domestiques purent y être assez précisément datés de la deuxième moite du XVIIe siècle. Us révélèrent la prépondérance très nette des céramiques vraisemblablement locales (de la vallée de l'Huveaune, dans l'arrière-pays marseillais) sur les productions extérieures à la région, qui ne doivent plus leur présence qu'à leur fonction spécifique. La production locale assure alors les trois-quarts de la consommation, en offrant une grande diversité de formes et de décors pour une assez bonne qualité.
De la ferme au village : Dassargues du Ve au Xlle siècle (Lunel, Hérault)
Authors: Garnier Bruno , Garnotel Alexandrine , Mercier Catherine , Raynaud Claude 
Published: August 2013

Entre Camargue et Garrigue, à mi-chemin entre Nîmes et Montpellier, l'habitat de Dassargues occupe la rive droite d'un fleuve, le Vidourle. L'étude du site s'insère dans une recherche pluridisciplinaire sur le peuplement et l'aménagement du littoral languedocien, de la conquête romaine à la fin du Moyen Age. Ténue au début de la période romaine, l'occupation du site s'intensifie à partir du Ve s. pour se prolonger jusqu'au Xlle s. L'habitat connaît ensuite une phase de déclin et n'est plus occupé que ponctuellement jusqu'au XI Ve s., tandis que le terroir, englobé dans le territoire du castrum de Lunel, demeure densément exploité. Cette étude de cas illustre les temps forts de l'histoire régionale, depuis la conquête agraire tardo-antique jusqu'à l'affirmation de la société féodale dans le cadre du maillage castrai.
Des fouilles sur plus de 2 ha ont mis au jour plusieurs habitations, une église et plusieurs ensembles funéraires, mais l'essentiel des vestiges concerne l'aménagement agraire : chemins, parcellaires fossoyés, traces de plantation, silos, cabanes. Textes, prospections régionales, carto- et photo-interprétation, sont exploités conjointement et étayent l'interprétation des données de fouille.
Water and side‐chain embedded π‐turns
Authors: Dasgupta Bhaskar , Dey Sucharita , Chakrabarti Pinak 
Published: August 2013

ABSTRACTElucidating protein function from its structure is central to the understanding of cellular mechanisms. This involves deciphering the dependence of local structural motifs on sequence. These structural motifs may be stabilized by direct or water‐mediated hydrogen bonding among the constituent residues. π‐Turns, defined by interactions between (i) and (i + 5) positions, are large enough to contain a central space that can embed a water molecule (or a protein moiety) to form a stable structure. This work is an analysis of such embedded π‐turns using a nonredundant dataset of protein structures. A total of 2965 embedded π‐turns have been identified, as also 281 embedded Schellman motif, a type of π‐turn which occurs at the C‐termini of α‐helices. Embedded π‐turns and Schellman motifs have been classified on the basis of the protein atoms of the terminal turn residues that are linked by the embedded moiety, conformation, residue composition, and compared with the turns that have terminal residues connected by direct hydrogen bonds. Geometrically, the turns have been fitted to a circle and the position of the linker relative to its center analyzed. The hydroxyl group of Ser and Thr, located at (i + 3) position, is the most prominent linker for the side‐chain mediated π‐turns. Consideration of residue conservation among homologous sequences indicates the terminal and the linker positions to be the most conserved. The embedded π‐turn as a binding site (for the linker) is discussed in the context of “nest,” a concave depression that is formed in protein structures with adjacent residues having enantiomeric main‐chain conformations. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 441–453, 2014.
The Potential of IR Micro‐Imaging for In‐situ Studies of Chemical Reactions in Nanoporous Catalysts
Authors: Kullmann Jens , Küster Christian , Titze Tobias , Chmelik Christian , Gläser Roger , Enke Dirk , Prager Lutz 
Published: August 2013

AbstractDie In‐situ‐Untersuchung chemischer Reaktionen ist ein derzeit intensiv bearbeitetes Forschungsgebiet. Ein geeignetes Verfahren ist die IR‐Micro‐Imaging‐Technik, die es ermöglicht, orts‐ und zeitaufgelöste IR‐Spektren aufzunehmen. Die Herstellung eines Modells mit 3D‐Porensystem für die In‐situ‐Aufzeichnung von Konzentrationsprofilen mittels IR‐Micro‐Imaging wird beschrieben, das die orts‐ und zeitaufgelöste Verfolgung katalytischer Reaktionen in nanoporösen Trägerkatalysatoren erstmals ermöglicht. Das Modellsystem besteht aus einem nanoporösen Glasmonolithen mit gasdichter Oberflächenversiegelung und ermöglicht die Aufzeichnung der Konzentrationsprofile von Cyclohexan und Cyclohexan/Benzol‐Gemischen als Funktion der Zeit.
Infinite Metal–Carboxylate Nanotube Constructed Metal–Organic Frameworks and Gas Sorption Properties
Authors: Lv Xiaoxia , Tang Sifu , Li Liangjun , Cai Jinjun , Wang Chao , Xu Xianrui , Zhao Xuebo 
Published: August 2013

AbstractTwo isomorphic microporous metal–organic frameworks (MOFs), [Co2L(H2O)2]·4.5H2O (1) and [Ni2L(H2O)2]·3.5H2O (2), were synthesized by the reaction of an aminopolycarboxylate ligand (H4L) with Co and Ni hydroxides under hydrothermal conditions. The exquisite assembly of the carboxylate, imino groups, and metal ions resulted in a 1D special nanotube that could be used as a blueprint for the construction of MOFs. By joining the nanotubes with the V‐shaped –CH2(C6H)(CH3)3CH2– spacer, a 3D framework with 1D triangular channels was formed. The two isostructural frameworks exhibited stability up to 350 °C. Gas sorption studies for N2, H2, CO2, and CH4 confirmed their permanent porosity.
Food‐grade bicontinuous microemulsions
Authors: Tchakalova Vera , Bailly Christine , Fieber Wolfgang 
Published: August 2013

AbstractMicroemulsions stabilized by sucrose esters in combination with lecithin are interesting flavour delivery systems because they allow the solubilization of very high levels of oil into an aqueous phase with relatively small amounts of surfactants. The aim of this study was to investigate microemulsions stabilized by these surfactants in order to determine the microemulsion type and the solubilizing capacity of the structures. Based on these results a good control and easy handling of the delivery systems is feasible. Pulsed Field Gradient (PFG) diffusion nuclear magnetic resonance spectroscopy revealed that at some specific ratios between both surfactants the formation of bicontinuous microemulsions takes place. In such systems, between 20% and 60% of the oil phase can be solubilized. The solubilization of lecithin in the flavour oil and the insertion of this mixture into a system containing direct micelles of sucrose ester changes the curvature of structures and allows the continuous transition from direct oil/water to bicontinuous structures to inverse water/oil microemulsions. In such inverse microemulsions up to 80% of flavour oil can be solubilized. Our investigation demonstrates that the presence of lecithin leads to an increase of the flavour oil loading, decreasing significantly the total surfactant concentration. Therefore, lecithin can be used as a tuning parameter to control the different types of microemulsions without additional hydrotropes and they can be easily adapted to different industrial applications. Copyright © 2013 John Wiley & Sons, Ltd.