bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy
Authors: Komatsu Masaaki , Wheeler Heather E. , Chung Suyoun , Low Siew-Kee , Wing Claudia , Delaney Shannon M. , Gorsic Lidija K. , Takahashi Atsushi , Kubo Michiaki , Kroetz Deanna L. , Zhang Wei , Nakamura Yusuke , Dolan M. Eileen 
Published: May 2015

Abstract
Purpose: Paclitaxel is used worldwide in the treatment of breast, lung, ovarian, and other cancers. Sensory peripheral neuropathy is an associated adverse effect that cannot be predicted, prevented, or mitigated. To better understand the contribution of germline genetic variation to paclitaxel-induced peripheral neuropathy, we undertook an integrative approach that combines genome-wide association study (GWAS) data generated from HapMap lymphoblastoid cell lines (LCL) and Asian patients.
Methods: GWAS was performed with paclitaxel-induced cytotoxicity generated in 363 LCLs and with paclitaxel-induced neuropathy from 145 Asian patients. A gene-based approach was used to identify overlapping genes and compare with a European clinical cohort of paclitaxel-induced neuropathy. Neurons derived from human-induced pluripotent stem cells were used for functional validation of candidate genes.
Results: SNPs near AIPL1 were significantly associated with paclitaxel-induced cytotoxicity in Asian LCLs (P &lt; 10−6). Decreased expression of AIPL1 resulted in decreased sensitivity of neurons to paclitaxel by inducing neurite morphologic changes as measured by increased relative total outgrowth, number of processes and mean process length. Using a gene-based analysis, there were 32 genes that overlapped between Asian LCL cytotoxicity and Asian patient neuropathy (P &lt; 0.05), including BCR. Upon BCR knockdown, there was an increase in neuronal sensitivity to paclitaxel as measured by neurite morphologic characteristics.
Conclusions: We identified genetic variants associated with Asian paclitaxel-induced cytotoxicity and functionally validated the AIPL1 and BCR in a neuronal cell model. Furthermore, the integrative pharmacogenomics approach of LCL/patient GWAS may help prioritize target genes associated with chemotherapeutic-induced peripheral neuropathy. Clin Cancer Res; 21(19); 4337–46. ©2015 AACR.
Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations
Authors: Bonelli Mara A. , Cavazzoni Andrea , Saccani Francesca , Alfieri Roberta R. , Quaini Federico , La Monica Silvia , Galetti Maricla , Cretella Daniele , Caffarra Cristina , Madeddu Denise , Frati Caterina , Lagrasta Costanza Annamaria , Falco Angela , Rossetti Pietro , Fumarola Claudia , Tiseo Marcello , Petronini Pier Giorgio , Ardizzoni Andrea 
Published: May 2015

Abstract
A prominent role in the pathogenesis of squamous cell carcinoma of the lung (SQCLC) has been attributed to the aberrant activation of the PI3K signaling pathway, due to amplification or mutations of the p110α subunit of class I phosphatidylinositol 3-kinase (PIK3CA) gene. The aim of our study was to determine whether different genetic alterations of PIK3CA affect the biologic properties of SQCLC and to evaluate the response to specific targeting agents in vitro and in vivo. The effects of NVP-BEZ235, NVP-BKM120, and NVP-BYL719 on two-dimensional/three-dimensional (2D/3D) cellular growth, epithelial-to-mesenchymal transition, and invasiveness were evaluated in E545K or H1047R PIK3CA–mutated SQCLC cells and in newly generated clones carrying PIK3CA alterations, as well as in a xenograft model. PIK3CA mutated/amplified cells showed increased growth rate and enhanced migration and invasiveness, associated with an increased activity of RhoA family proteins and the acquisition of a mesenchymal phenotype. PI3K inhibitors reverted this aggressive phenotype by reducing metalloproteinase production, RhoA activity, and the expression of mesenchymal markers, with the specific PI3K inhibitors NVP-BKM120 and NVP-BYL719 being more effective than the dual PI3K/mTOR inhibitor NVP-BEZ235. A xenograft model of SQCLC confirmed that PIK3CA mutation promotes the acquisition of a mesenchymal phenotype in vivo and proved the efficacy of its specific targeting drug NVP-BYL719 in reducing the growth and the expression of mesenchymal markers in xenotransplanted tumors. These data indicate that PIK3CA mutation/amplification may represent a good predictive feature for the clinical application of specific PI3K inhibitors in SQCLC patients. Mol Cancer Ther; 14(8); 1916–27. ©2015 AACR.
Lower Coated-Platelet Levels Are Associated With Increased Mortality After Spontaneous Intracerebral Hemorrhage
Authors: Prodan Calin I. , Stoner Julie A. , Dale George L. 
Published: May 2015

Background and Purpose—
Coated-platelets are highly procoagulant platelets observed on dual-agonist stimulation with collagen and thrombin. Coated-platelet levels are decreased in patients with spontaneous intracerebral hemorrhage when compared with controls and inversely correlated with bleed volume. We sought to investigate whether coated-platelets are associated with increased mortality at 30 days after spontaneous intracerebral hemorrhage.

Methods—
Coated-platelet levels were assayed in 95 consecutive patients with spontaneous intracerebral hemorrhage. The main outcome was mortality at 30 days according to coated-platelet levels at enrollment. Subjects were grouped into tertiles of the observed coated-platelet level distribution. Groups defined by tertile of coated-platelet level were compared using either ANOVA or a Kruskal–Wallis test for small group size for continuous measures and an exact Cochrane–Armitage trend test for categorical measures. Logistic regression was used to estimate the adjusted odds of death within 30 days associated with coated-platelet levels.

Results—

Cumulative mortality at 30 days was 23% (22 subjects). Mortality at 30 days differed among the coated-platelet tertiles: 44% for the first tertile (lowest coated-platelet levels), 19% for the second tertile, and 6% for the third tertile (trend test;
P
=0.0004). Logistic regression examining the association between mortality and coated-platelet levels showed that the odds of death at 30 days in those with levels <27% (n=47) were 6.83× the odds for patients with levels ≥27% (95% confidence interval, 2.10–22.23).

Conclusions—
These results support a link between impaired coated-platelet potential and outcome in intracerebral hemorrhage.
Preface and Constitution of the Asian Society of Ichthyologists
Authors: PAGE LAWRENCE M. , NOR SITI AZIZAH MOHD 
Published: May 2015

The U.S. National Science Foundation-funded (DEB 1022720) ‘All Cypriniformes Species Inventory’ was initiated in 2010 and will be completed in 2015. It has accelerated the rate of discovery and description of cypriniform fishes, expanded our knowledge of the phylogenetic relationships of cypriniforms, increased the capacity for systematic research in other countries through student training and establishing long-term collaborations, including conferences in Thailand in 2012, Brunei in 2013, Burundi in 2013, and Malaysia in 2014, led to the formation of the Asian Society of Ichthyologists, and made available large numbers of specimens and tissues of freshwater fishes, including many species never before collected, in permanent collections in foreign and U.S. institutions.
Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD
Authors: Chopra Martin , Brandl Andreas , Siegmund Daniela , Mottok Anja , Schäfer Viktoria , Biehl Marlene , Kraus Sabrina , Bäuerlein Carina A. , Ritz Miriam , Mattenheimer Katharina , Schwinn Stefanie , Seher Axel , Grabinger Thomas , Einsele Hermann , Rosenwald Andreas , Brunner Thomas , Beilhack Andreas , Wajant Harald 
Published: May 2015

Key Points
Fn14 activation is involved in intestinal apoptosis after allo-HCT and contributes to gastrointestinal GVHD. Fn14 blockade with an ADCC-defective human immunoglobulin G1 antibody reduces GVHD severity without modulating GVL responses.
Hematopoietic stem cell transplantation for infantile osteopetrosis
Authors: Orchard Paul J. , Fasth Anders L. , Le Rademacher Jennifer , He Wensheng , Boelens Jaap Jan , Horwitz Edwin M. , Al-Seraihy Amal , Ayas Mouhab , Bonfim Carmem M. , Boulad Farid , Lund Troy , Buchbinder David K. , Kapoor Neena , O’Brien Tracey A. , Perez Miguel A. Diaz , Veys Paul A. , Eapen Mary 
Published: May 2015

Key PointsHematopoietic cell transplantation results in long-term survival. Primary graft failure is very high and the predominant cause of death.
Magnetic Properties of Cluster Glassy Ni/NiO Core–Shell Nanoparticles: an Investigation of Their Static and Dynamic Magnetization
Authors: Ji Jhong-Yi , Shih Po-Hsun , Chan Ting-Shan , Ma Yuan-Ron , Wu Sheng Yun 
Published: May 2015

Abstract
We review the phenomenology of the exchange bias and its related effects in core–shell nanocrystals. The static and dynamic properties of the magnetization for ferromagnetic Ni-core and antiferromagnetic NiO-shell cluster glassy nanoparticles are examined, along with the pinning–depinning process, through the measurement of the conventional exchange bias, and associated with different cooling fields and particle sizes. Two significant indexes for the dipolar interaction n and multi-anisotropic barrier β derived from the dynamic magnetization are proposed, which provide a unified picture of the exchange bias mechanism and insight into the influence of the cooling field.
Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study
Authors: Jaeckels Nadine , Bellinghausen Iris , Fronk Petra , Heydenreich Bärbel , Saloga Joachim , Decker Heinz 
Published: May 2015

AbstractBackgroundIn a recently performed survey with 4000 randomly selected persons, 68 (7.2 %) of 948 respondents reported intolerance and/or allergy‐like symptoms to wine. The aim of this study was to analyze whether a real sensitization to wine proteins could be confirmed by diagnostic and/or immunological settings.FindingsFor this purpose, 19 subjects with self‐reported intolerance to wine of the invited subjects and 10 controls without a history of intolerance participated in an allergological examination (skin prick test, ImmunoCAP for determination of specific IgE antibodies, CAST for testing basophil activation, ImmunoBlot for testing specificity of IgE‐antibodies). For the allergological work‐up red and white grapes, selected wines, and the purified lipid transfer protein (LTP), a known grape allergen, were used. 7 subjects showed evidence of IgE sensitization to wine or grape extracts, including one control. One participant with symptoms of intolerance showed a positive skin prick test to red grape, a positive ImmunoCAP to grape, a positive cellular antigen stimulation test (CAST) and inhibition of Western blot by removal of cross‐reactive carbohydrate determinants (CCD).ConclusionThe presented study focused on the grape protein‐related IgE‐mediated cause of intolerance to wine (true allergy) and not on other wine components or fining agents (other forms of intolerance). A sensitization to grape and wine proteins was observed in our cohort. In one case, this reactivity could be explained by cross‐reactivity to CCD. The results of this pilot study need to be validated in greater cohorts.
Clinical Development Strategies and Outcomes in First-in-Human Trials of Monoclonal Antibodies
Authors: Tosi Diego , Laghzali Yassine , Vinches Marie , Alexandre Marie , Homicsko Krisztian , Fasolo Angelica , Del Conte Gianluca , Durigova Anna , Hayaoui Nadia , Gourgou Sophie , Gianni Luca , Mollevi Caroline 
Published: May 2015

Purpose We conducted a comprehensive review of the design, implementation, and outcome of first-in-human (FIH) trials of monoclonal antibodies (mAbs) to clearly determine early clinical development strategies for this class of compounds. Methods We performed a PubMed search using appropriate terms to identify reports of FIH trials of mAbs published in peer-reviewed journals between January 2000 and April 2013. Results A total of 82 publications describing FIH trials were selected for analysis. Only 27 articles (33%) reported the criteria used for selecting the starting dose (SD). Dose escalation was performed using rule-based methods in 66 trials (80%). The median number of planned dose levels was five (range, two to 13). The median of the ratio between the highest planned dose and the SD was 27 (range, two to 3,333). Although in 56 studies (68%) at least one grade 3 or 4 toxicity event was reported, no dose-limiting toxicity was observed in 47 trials (57%). The highest planned dose was reached in all trials, but the maximum-tolerated dose (MTD) was defined in only 13 studies (16%). The median of the ratio between MTD and SD was eight (range, four to 1,000). The recommended phase II dose was indicated in 34 studies (41%), but in 25 (73%) of these trials, this dose was chosen without considering toxicity as the main selection criterion. Conclusion This literature review highlights the broad design heterogeneity of FIH trials testing mAbs. Because of the limited observed toxicity, the MTD was infrequently reached, and therefore, the recommended phase II dose for subsequent clinical trials was only tentatively defined.
Case Report: Atypical Cornelia de Lange Syndrome
Authors: Leanza Vito , Rubbino Gabriella , Leanza Gianluca 
Published: May 2015

Cornelia de Lange Syndrome (CdLS) (also called Bushy Syndrome or Amsterdam dwarfism), is a genetic disorder that can lead to several alterations. This disease affects both physical and neuropsychiatric development. The various abnormalities include facial dysmorphia (arched eyebrows, synophrys, depressed nasal bridge, long philtrum, down-turned angles of the mouth), upper-extremity malformations, hirsutism, cardiac defects, and gastrointestinal alterations. The prevalence of this syndrome is approximately one per 15,000. Ultrasound is not the perfect means to diagnose CdLS, however, many abnormalities can be detected prenatally by scrupulous image observation.We report an atypical CdLS case characterized by increased nuchal translucency in the first trimester, normal karyotype, saddle nose, micrognathia with receding jaw, low set ears, facies senilis, arthrogryposis of the hands, absence of the Aranzio ductus venous, dilatation of gallbladder and bowel, a unique umbilical artery, increased volume of amniotic fluid, and intrauterine growth retardation ending with the interruption of pregnancy.
Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism
Authors: Kitao Yasuko , Ageta-Ishihara Natsumi , Takahashi Ryosuke , Kinoshita Makoto , Hori Osamu 
Published: May 2015

BackgroundDopamine (DA) neuron-selective uptake and toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes parkinsonism in humans. Loss of DA neurons via mitochondrial damage and oxidative stress is reproduced by systemic injection of MPTP in animals, which serves as models of parkinsonism and Parkinson’s disease (PD). This study aimed to test whether pan-neural supplementation of the longevity-related, pleiotropic deacetylase SIRT1, which confers partial tolerance to at least three models of stroke and neurodegeneration, could also alleviate MPTP-induced acute pathological changes in nigrostriatal DA neurons and neighboring glia.ResultsWe employed a line of prion promoter-driven Sirt1-transgenic (Sirt1Tg) mice that chronically overexpress murine SIRT1 in the brain and spinal cord. Sirt1Tg and wild-type (WT) male littermates (3‒4 months old) were subjected to intraperitoneal injection of MPTP. Acute histopathological changes in the midbrain and striatum (caudoputamen) were assessed with serial coronal sections triply labeled for tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), and nuclear DNA. In the substantia nigra pars compacta (SNpc) of the midbrain, the number of TH-positive neurons and the reactive gliosis were comparable between the Sirt1Tg and WT littermates. In the striatum, the relative fluorescence intensity of TH-positive nerve terminals and the level of gliosis did not differ by the genotypes.ConclusionsSirt1Tg and WT littermate mice exhibited comparable acute histopathological reactions to the systemic injection of MPTP, loss of TH-positive neurons and reactive gliosis. Thus, the genetic supplementation of SIRT1 does not confer histologically recognizable protection on nigrostriatal DA neurons against acute toxicity of MPTP.
Legal bases of the state ecological development
Authors: Хлуденева Наталья , Khludeneva Natalya 
Published: May 2015

The ecological right is an important component of creation of optimum model of legal regulation of environmental protection at the present stage. Its aim is to protect the environmental interests of society by securing legal restrictions and prohibitions against excessive use of natural resources, often rash and irrational, and also to establish the effective measures of legal protection.
The author investiges the strategic planning documents in the field of environmental protection, evaluates the effectiveness of their implementation, and suggests the improvements of legal regulation of environmental protection in Russia.
Rozwój europejskiej polityki cyfrowej
Authors: Posłajko Robert 
Published: May 2015

Shaping European Digital Policy
Modern information and communication technologies (ICT) have a significant impact on society and economy. This influence gets more and more interest from researchers and public authorities. The information society influences most areas of life, hence it requires a joint action in the fields of communication, copyright, data protection, cybercrime, R&D, trade, fair competition and consumer protection. There is a particularly relevant question about an integrated policy towards ICT by international organizations and states. Although EU has only recently addressed the issue of ICT, this phenomenon is becoming progressively more far‑reaching. The main objective of this study was to investigate European Union’s policy on information society.
Value of Reconstruction Procedures (non-microsurgical) on Facial Defects Postexcision of a Basocellular Carcinomas
Authors: Dimitropoulou Theodora , Iordache I.V , Poalelungi T. , Caraban B.M. , Bordeianu I. 
Published: May 2015

Abstract
The authors present a retrospective study - 2011-1014 on value of reconstructive nonmicrosurgicals procedures after excisions of facial basocellular carcinomas.
The study group included 426 cases of basocellular carcinomas of the face (primary diagnosed or recurrent) that required reconstructive procedure after excision in oncology margin (according to the criteria of the clinic). The choice is eclectically considering reconstructive process (evaluating) a number of factors: patient age, location of carcinoma, post excisional defect size and pathological status (recurrence, radiation) and the frequency of the primary outcome was using plastic reconstruction of full-thickness free skin.
All cases included in the study received a performant dermatoscopic exam and excisions were performed at 5-10 mm from the edges of the apparent surface and in deepness in fascial plane.
Heat conduction and Thermal Stress Analysis of
laminated composites by a variable kinematic
MITC9 shell element
Authors: Cinefra M. , Valvano S. , Carrera E. 
Published: May 2015

Abstract
The present paper considers the linear static
thermal stress analysis of composite structures by means
of a shell finite element with variable through-thethickness
kinematic. The temperature profile along the
thickness direction is calculated by solving the Fourier
heat conduction equation. The refined models considered
are both Equivalent Single Layer (ESL) and Layer
Wise (LW) and are grouped in the Unified Formulation
by Carrera (CUF). These permit the distribution of displacements,
stresses along the thickness of the multilayered
shell to be accurately described. The shell element
has nine nodes, and the Mixed Interpolation of Tensorial
Components (MITC) method is used to contrast the
membrane and shear locking phenomenon. The governing
equations are derived from the Principle of Virtual Displacement
(PVD). Cross-ply plate, cylindrical and spherical
shells with simply-supported edges and subjected to
bi-sinusoidal thermal load are analyzed.Various thickness
ratios and curvature ratios are considered. The results, obtained
with different theories contained in the CUF, are
compared with both the elasticity solutions given in the
literature and the analytical solutions obtained using the
CUF and the Navier’s method. Finally, plates and shells
with different lamination and boundary conditions are analyzed
using high-order theories in order to provide FEM
benchmark solutions.
Non-linear flow-induced vibrations in deformable
curved bodies: A lattice Boltzmann-immersed
boundary-finite element study
Authors: De Rosis Alessandro 
Published: May 2015

Abstract
The dynamic response of a deformable curved
solid body is investigated as it interacts with a flow field.
The fluid is assumed to be viscous and the flow is nearly
incompressible. Fluid dynamics is predicted through a
lattice Boltzmann solver. Corotational beam finite elements
undergoing large displacements are adopted to idealize
the submerged body, whose presence in the lattice
fluid background is handled by the immersed boundary
method. The attention focuses on the solid’s deformation
and a numerical campaign is carried out. Findings are reported
in terms of deformation energy and deformed configuration.
On the one hand, it is shown that the solution
of the problem is strictly dependent on the elastic properties
of the body. On the other hand, the encompassing
flow physics plays a crucial role on the resultant solid dynamics.
With respect to the existing literature, the present
problem is attacked by a new point of view. Specifically,
the author proposes that the problem is governed by four
dimensionless parameters: the Reynolds number, the normalized
elastic modulus, the density and aspect ratii. The
formulation and the solution strategy for curved solid bodies
herein adopted are introduced for the first time in this
paper.
Gelotophobia: Life satisfaction and happiness across cultures
Authors: Proyer René T. , Ruch Willibald , Chen Guo-Hai 
Published: May 2015

AbstractThe fear of being laughed at (gelotophobia) was examined in its relations to concepts from positive psychology in Austria, China, and Switzerland. It was related to satisfaction with life and Peterson et al.'s (2005) three orientations to happiness; the life of pleasure (hedonism), life of engagement (related to flow-experiences), and life of meaning (eudaimonia). Participants (
The ancient roots of humor theory
Authors: Perks Lisa Glebatis 
Published: May 2015

AbstractMany modern humor scholars have oversimplified their summaries of Plato, Aristotle, Cicero and Quintilian's views on humor, focusing on the philosophers' cautionary warnings about the rhetorical efficacy and ethics of humor. Although the philosophers did write much on the offensive nature of jests, which can be considered illustrative of superiority theory, I describe elements of the incongruity and relief theories of humor motivation in their work. There is evidence to suggest that all four philosophers found humor to be a fitting and effective response to certain exigencies. It is more accurate to summarize their views thus: Humor has the potential to be a powerful tool of persuasion, but like any potent weapon (discursive or non-discursive) it should be used with caution.