bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leser‐Trélat Sign Associated with Sézary Syndrome
Authors: Ikari Yuko , Ohkura Mitsuhiro , Morita Makoto , Seki Kenjiro , Kubota Yasuo , Mizoguchi Masako 
Published: April 2015

AbstractA 74‐year‐old Japanese male had developed generalized erythroderma and rapid growth of multiple verrucous lesions over the entire surface of his face, trunk, and extremities three months before he was seen. Histologically seborrheic keratoses were revealed. Laboratory examinations showed peripheral leukocytosis with atypical lymphocytes and high levels of IgE and IgG. On the basis of these clinical and histopathologic findings, we diagnosed the patient as having Leser‐Trélat sign associated with Sézary syndrome.The erythroderma subsided after administration of oral predonisone, and no new formations of seborrheic keratosis were observed. However, because of subsequent aggravation of the generalized erythroderma, we administered chemotherapy. Six months after the initial examination, lung cancer was found, and the patient subsequently died of respiratory and renal failure.
Cutaneous Sporotrichosis and Distant Autoinoculation
Authors: Kim Han Uk , Yun Seok Kweon , Ihm Chull Wan 
Published: April 2015

AbstractA 56‐year‐old woman suffering from cutaneous sporotrichosis on the right cheek and right knee is described. The sporotrichotic nodule of the knee was thought to have been caused by distant autoinoculation.
Three Cases of Chemotherapy‐induced Acral Erythema
Authors: Komamura Hiromi , Higashiyama Mari , Hashimoto Koji , Takeda Kiyoshi , Kimura Hiromi , Tani Yoshihiko , Ogawa Hiroyasu , Yoshikawa Kunihiko 
Published: April 2015

AbstractThree cases of chemotherapy‐induced acral erythema are reported. All the patients had received cyclophosphamide, vincristine, adriamycin, prednisolone, and granulocyte‐colony stimulating factor (G‐CSF) for the treatment of leukemia or malignant lymphoma. From 35 to 45 days after the start of chemotherapy, painful erythematous lesions developed on their palms, soles, fingers, and toes, resulting in blister formation and desquamation. The recent higher incidence of chemotherapy‐induced acral erythema may be correlated with the popularity of G‐CSF, which allows the use of higher doses of chemotherapeutic drugs.
Association of the Acral Type of Pustular Psoriasis, Sjögren's Syndrome, Systemic Lupus Erythematosus, and Hashimoto's Thyroiditis
Authors: Kobayashi Takashi , Naka Wataru , Harada Takashi , Nishikawa Takeji 
Published: April 2015

AbstractWe describe a case of a 53‐year‐old Japanese female suffering from Sjögren's syndrome, systemic lupus erythematosus, and Hashimoto's thyroiditis who developed pustules, erythema, and erosions on her fingers and toes. The histological specimen showed psoriatic changes. Indirect immunofluorescent study using anti‐human IL (interleukin)‐8 antibody produced positive staining patterns in the lesional epidermis. These findings suggested the diagnosis of acral pustular psoriasis. Diaminodiphenylsulfone at 75 mg orally daily for 20 days and the application of 0.12% betamethasone valerate ointment led to gradual improvement.
Melkersson‐Rosenthal Syndrome in India: Experience with Six Cases
Authors: Dhar Sandipan , Kanwar Amrinder J. 
Published: April 2015

AbstractSix patients with Melkersson‐Rosenthal syndrome (M‐R syndrome) were presented. Their ages varied from 20 to 60 years; age at onset was between 15 and 50 years. In all 6 patients, swelling started first over the lower lip. Associated facial palsy, facial edema, and scrotal tongue were found in three, four and one patients, respectively. Lip biopsies from 5 patients failed to show any granuloma. Intralesional corticosteroids produced mild regression of labial swelling in two patients after 6 injections. In one patient, near total reduction of labial swelling and facial edema was achieved after 5 months of clofazimine treatment. However, there was no improvement of facial palsy. To the best of our knowledge, this is the largest series of M‐R syndrome reported from India.
Clinical Analysis of Recurrent Hypergammaglobulinemic Purpura Associated with Sjögren Syndrome
Authors: Katayama Ichiro 
Published: April 2015

AbstractRecurrent purpuric lesions are occasionally seen in patients with Sjögren syndrome. Hypergammaglobulinemia is one of the underlying precipitating factors of this condition. Clinical and histopathological analyses were performed on 5 cases of hypergammaglobulinemic purpura associated with Sjögren's syndrome, and the effects of immunomodulatory therapy were evaluated with regards to these conditions.Three out of 5 cases were successfully treated with oral gold compound (Auranofin) and one case with a low dose of cyclophosphamide. Episodic purpura subsided two months after initiation of therapy with improved serum IgG levels. Salivary flow and serum amylase levels also improved in some cases.Immunomodulatory therapy may be useful in managing recurrent purpura based on hypergammaglobulinemia associated with Sjögren syndrome.
Mortality of Neurofibromatosis in Japan, 1968–1992
Authors: Imaizumi Yoko 
Published: April 2015

AbstractThe death rate from neurofibromatosis (NF) was analyzed using Japanese vital statistics for the period 1968–1992. NF death rates for females decreased significantly year by year, but there was no significant change for males. Overall NF death rates were 0.25 per million population for males and 0.19 for females. The age‐specific NF death rate increased with age during that period. The overall mean age at death from NF was 43 years for both sexes. There were no geographical variations in the NF death rate during the period 1977–1992.
Pemphigoid Nodularis: A Case with 230 kDa Hemidesmosomes Antigen Associated with Bullous Pemphigoid Antigen
Authors: Tamada Yasuhiko , Yokochi Kikuka , Oshitani Yoshimi , Nitta Yukiko , Ikeya Toshihiko , Hara Kazuo , Owaribe Katsushi 
Published: April 2015

AbstractWe report a 73‐year‐old woman with typical clinical, histological and immunofluorescence features of pemphigoid nodularis. Direct immunofluorescence studies of prurigo nodularis‐like lesions and peribullous skin showed the linear deposition of IgG and C3 at the basement membrane zone. Circulating IgG against the basement membrane was also detected by indirect immunofluorescence. The serum from the patient was shown to contain the autoantibody against 230 kDa hemidesmosomal antigen associated with bullous pemphigoid antigen.
Systemic Plasmacytosis: A Case which Improved with Melphalan
Authors: Lee Dong Won , Choi Sung Woo , Park Jong Won , Cho Baik Kee 
Published: April 2015

AbstractPlasmacytosis, a distinctive proliferative disorder of plasma cells, is characterized by peculiar multiple skin eruptions, lymphadenopathy and polyclonal hypergammaglobulinemia.To date there has been no report of such cases showing remarkable responses to therapeutic agents.We herein report a case of plasmacytosis which developed in a 52‐year‐old Korean man and showed remarkable improvement with melphalan.
Primary Sjögren's Syndrome and Psoriasis Vulgaris in a Case of OKT4 Epitope Deficiency
Authors: Tanaka Hideyuki , Mizutani Hitoshi , Okada Hiroaki , Shimizu Masayuki 
Published: April 2015

AbstractWe report a 29‐year‐old female OKT4 epitope deficiency patient with primary Sjögren's syndrome and psoriasis vulgaris. Immunological investigations during the prolonged clinical course of her herpes zoster revealed that she has OKT4 epitope deficiency and primary Sjögren's syndrome. She had been treated for psoriasis vulgaris for 17 years without systemic immunosuppressive therapy. Flow cytometric study revealed that her OKT4 deficiency is heterogeneous and excluded interference with the OKT4 epitope by anti OKT4 autoantibodies. The rare coexistence of primary Sjögren's syndrome and psoriasis implicates an immune disturbance due to an unusual phenotype of CD4.
Nodular Scleroderma: Focally Increased Tenascin Expression Differing from That in the Surrounding Scleroderma Skin
Authors: Mizutani Hitoshi , Taniguchi Hirotaka , Sakakura Teruyo , Shimizu Masayuki 
Published: April 2015

AbstractNodular scleroderma is a rare variant of the disease, whose pathogenesis is uncertain. Tenascin is a recently cloned extracellular matrix protein which is thought to be a marker for tissue remodelling. To further investigate the pathogenesis of nodular scleroderma, we have followed up a case of this disease and studied tenascin expression in the nodular lesions and surrounding progressive systemic sclerosis skin. Previously, we demonstrated a long‐lasting intermediate level of dermal tenascin expression in progressive systemic sclerosis; morphea and hypertrophic scar lesions showed strong but short‐lived tenascin expression. In our current patient, high levels of tenascin were found in the nodules, which rapidly resolved. Thus, the time course of the clinical and histopathological findings together with the tenascin expression were more suggestive of hypertrophic scar than progressive systemic sclerosis. These findings imply that nodular scleroderma has a supplementary pathogenesis, such as itching, in addition to the proceeding systemic sclerosis.
Langerhans Cell Histiocytosis: A Case Report and Glimpses into Its Nomenclature
Authors: Sehgal Virendra N. , Jain Sanjiv , Chander Ram , Logani Kulbhushan 
Published: April 2015

AbstractClass I Langerhans cell histiocytosis (LCH) is described in a two‐ and a half‐year‐old male. The initial expression of the disease was conspicuous by the presence of extensive pustular crusted rash and, later in its course, by purpura, diabetes insipidus, otitis media, enlargement of the liver and spleen, and infiltration into the lungs. The patient expired due to extensive hemorrhage over 24 hours.
Ulcerative Colitis Associated with Preceding Systemic Lupus Erythematosus
Authors: Ishikawa Osamu , Miyachi Yoshiki , Fujita Kinichi , Takenoshita Seiichi , Nagamachi Yukio , Hirato Junko 
Published: April 2015

AbstractWe report a 50‐year‐old female patient who developed ulcerative colitis 31 after years being diagnosed with systemic lupus erythematosus. The overall clinical evaluation of her SLE activity differentiated ulcerative colitis from lupus colitis. Since the association of idiopathic systemic lupus erythematosus with ulcerative colitis has rarely been reported, the combination of these two diseases may be coincidental.
Coexistence of Vitiligo and Morphea: A Case Report and Review of the Literature
Authors: Finkelstein Eve , Amichai Boaz , Metzker Aryeh 
Published: April 2015

AbstractA patient with both vitiligo and morphea is described. These skin diseases rarely appear concurrently in the same patient, despite the fact that both are thought to have an autoimmune etiology. Similar cases that have been reported in the literature are reviewed and discussed.
Sinus Arrest Developed during Gastric Cancer Operation in a Progressive Systemic Sclerosis Patient
Authors: Kihira Chika , Mizutani Hitoshi , Shimizu Masayuki 
Published: April 2015

AbstractWe report a case of progressive systemic sclerosis (PSS) who suddenly developed sinus arrest during an operation for gastric cancer under general anesthesia. No abnormalities in her cardiac, respiratory or renal functions had been detected before surgery. The cardiac functions evaluated by echocardiogram before and after pacemaking eliminated heart muscular involvement. We speculated that the operation stress induced by general anesthesia altered the asymptomatic fibrotic sinus into apparent sinus dysfunction. Care should be taken in general anesthesia for scleroderma patients who are free from detectable cardiac manifestations.
Cutaneous Ultrastructural Features of the Flaky Skin (fsn) Mouse Mutation
Authors: Morita Katsuko , Hogan Margaret E. , Nanney Lillian B. , King Lloyd E. , Manabe Motomu , Sun Tung‐Tien , Sundberg John P. 
Published: April 2015

AbstractAn autosomal recessive genetic disease with clinical and histopathological skin features resembling human psoriasis vulgaris occurs naturally in flaky skin mice (fsn/fsn). Affected mice are normal at birth, except for a hypochromic anemia. Subsequently, they develop hyperkeratotic plaques and acanthosis with elongation of rete ridges. Scanning electron microscopic examination revealed a greatly thickened epidermis, a sparsity of hairs and scale accumulations on the epidermal surface. Hair shafts had conspicuous pits, striations, and exophytic protrusions. Nails were bent at a 90° angle with surface irregularities and accumulations of scale at the nail base. Transmission electron microscopic examination showed increased epidermal thickness, mitochondrial aberrations, and intraepidermal invasion by neutrophils. Keratohyalin abnormalities were detected using immunocytochemical staining for profilaggrin. At the dermal‐epidermal junction, numerous macrophages and mast cells were seen in close promixity to focal dissolutions of the basement membrane. A high density of collagen fibers and cellular infiltrates were evident in the papillary dermis. This constellation of ultrastructural aberrations is typically found in psoriasis vulgaris and supports the theory that the flaky skin mouse mutation is a naturally occurring analog to one variety of human psoriasis vulgaris.
Proliferating Activity of the Hair Follicular Melanocytes at the Early and Anagen III Stages in the Hair Growth Cycle: Detection by Immunocytochemistry for Bromodeoxyuridine Combined with DOPA Reaction Cytochemistry
Authors: Sugiyama Sadao , Saga Kenji , Morimoto Yousuke , Takahashi Makoto 
Published: April 2015

AbstractIn order to demonstrate the existence of proliferating activity in hair follicular melanocytes during the early and anagen III stages, immunocytochemistry for bromodeoxyuridine (BrdU) incorporated in the nuclei of the melanocytes for 1 hr was undertaken at the light and electron microscopic levels in combination with DOPA reaction cytochemistry.Light microscopically, about 30% of the nuclei of the DOPA reaction positive melanocytes at the anagen III stage of the hair growth cycle were labeled by anti‐BrdU antibody. These melanocytes were observed in about one hundred hair follicles. Electron microscopically, the nuclei of a few undifferentiated melanocytes at the anagen II stage were labeled by anti‐BrdU antibody‐affiliated secondary antibody‐gold particles. At the anagen III stage, localization of the immunogold particles in the DNA replication domains of the nuclei of the undifferentiated and redifferentiating melanocytes covered the patterns of the early, middle, and late S‐phase.These findings suggest that the hair follicular melanocytes begin proliferation at the anagen II stage and that the melanocytes proliferate actively at the anagen III stage to repopulate the hair matrix during subsequent hair growth.
A Case of AIDS Manifesting Pruritic Papular Eruptions and Psoriasiform Lesions: An Immunohistochemical Study of the Lesional Dermal Infiltrates
Authors: Ichihashi Naoki , Seishima Mariko , Takahashi Takeshi , Muto Yasutoshi , Kitajima Yasuo 
Published: April 2015

AbstractA 63‐year‐old man was referred to our department on September 14, 1992, because of multiple red papules with severe itching. Pruritic papular eruption (PPE) in a human immunodeficiency virus (HIV)‐infected patient was diagnosed based on the histological findings, the reduction in CD4, and positive results for HIV antibody. In September of 1993, papules and erythematous plaques with scales appeared on both the palms and soles. The erythema was pruritic and spread gradually to the extremities and trunk. These plaques with erythema and scales are similar to those of the psoriatic lesions seen in Reiter's syndrome, although the HLA typing was not B27. Immunohistopathological findings of the papules of PPE and plaques of psoriasiform lesions showed that perivascularly infiltrated cells in the dermis were mostly lymphocytes. The lymphocytes in PPE were positive for CD45 and negative for CD3, CD43, and CD45RO, but the lymphocytes in psoriasiform lesions were positive for CD45, CD3, and CD43. Moreover, 20–30% of these lymphocytes were also intensely positive for CD45RO. These observations were similar to those obtained in the lesional skin of HIV‐negative psoriasis, suggesting that there were no significant immunohistopathological differences in the abnormality of local cellular immunity related to the formation of psoriasiform lesions in HIV‐negative psoriasis and HIV‐positive psoriasis.
Graft Versus Host Disease with Mixed Chimerism
Authors: Morita Hideki , Kohno Junro , Kitano Yukio 
Published: April 2015

AbstractWe report a patient with graft versus host disease (GVHD) with mixed chimerism (MC). The patient had chronic myelogenous leukemia and received bone marrow transplantation (BMT) from his elder sister. Eighty days after BMT, erythematous lesions appeared on his chest. Histological examination from the skin lesion revealed lymphocytic infiltration into the upper dermis. Eosinophilic necrotic keratinocytes were scattered through the epidermis. Liquefaction degeneration was also recognized. Sicca syndrome appeared from 110 days after BMT. Detection of host origin Y‐chromosome‐specific DNA by polymerase chain reaction (PCR) method in bone marrow and peripheral blood showed that all bone marrow samples obtained 6 months from BMT were positive for Y‐specific DNA, while peripheral blood became positive in the 60th month after BMT. The host origin normal karyotype (46,XY) in the bone marrow samples was identified for the first time in the 60th month after BMT. These results indicate that host‐origin hematopoietic cells survived after BMT.
Bilateral Inguinal Scrofuloderma during Steroid Therapy in a Patient with Bullous Pemphigoid
Authors: Kawabata Emi , Morita Kazumasa , Matsuyoshi Norihisa , Ohta Keiji , Okamoto Hiroyuki , Ikai Kouichi , Imamura Sadao 
Published: April 2015

AbstractThis report described a case of scrofuloderma that developed in the bilateral inguinal regions during treatment of bullous pemphigoid with systemic corticosteroid. Analysis of the literature on scrofuloderma between 1978–1993 disclosed that the number of cases with extracervical involvement are increasing. Immunosuppression could disseminate tuberculous focuses, resulting in extracervical involvement of SD connected with the underlying extrapulmonary tuberculous lesions.
Primary Cutaneous Meningioma on the Scalp: Report of Two Siblings
Authors: Miyamoto Toru , Mihara Motoyuki , Hagari Yoshitaka , Shimao Shuhei 
Published: April 2015

AbstractPrimary cutaneous meningioma (PCM) is a rare tumor whose pathogenesis is quite obscure. We reported PCMs occurring on almost the same occipital region of two siblings studied by histology, immunohistochemistry, and electron microscopy. Both lesions were attached to duras, but extracranial. One lesion was histologically diagnosed as meningothelial meningioma; its tumor cells showed electron microscopically interdigitating cytoplasmic processes with junctional complexes. The other was interpreted as fibroblastic meningioma; its tumor cells were arranged linearly in a stepping‐stone arrangement and had small dense bodies in the cytoplasm. The tumor cells stained positively with anti‐vimentin antibody. Both lesions had adenomatous hyperplasia of the eccrine glands. Although the histologic and electron microscopic features of these two lesions slightly differed from each other, their pathogenesis was essentially considered to be acoelic or rudimentary meningocele.
Low Expression of Adhesion Molecules in a Case of Cutaneous T‐cell Lymphoma
Authors: Miyazawa Megumi , Takahashi Sanami , Kawaguchi Hiroshi , Nagatani Tetsuo , Higuchi Mitsuhiro , Matsuzaki Toshiko , Iemoto Gaijiro , Kim Shu‐Taku , Baba Naoko , Miyamoto Hideaki , Nakajima Hiroshi 
Published: April 2015

AbstractA case of cutaneous T‐cell lymphoma (CTCL) with low expression of the adhesion molecules lymphocyte function‐associated antigen‐1 (LFA‐1), intercellular adhesion molecule‐1 (ICAM‐1), and very late antigen‐4 (VLA‐4) is described. The patient was a 90‐year‐old man with red round homogeneous tumors on his scalp, trunk, and extremities. He had no history of definite erythema or plaque stage. A biopsy sample taken from a tumor revealed massive infiltration of atypical lymphocytes in the reticular dermis and subcutis with a definite clear zone. The atypical lymphocytes were medium‐sized with slightly convoluted nuclei. Immunohistochemically, the infiltrates showed the phenotype of so‐called memory T cells. On the basis of these features, the case was diagnosed as CTCL. Expression of LFA‐1, ICAM‐1 and VLA‐4 on the infiltrates was 9%, 13% and 11%, respectively, which is much lower than that in classic mycosis fungoides. This finding suggests that loss of these adhesion molecules may contribute to loss of epidermotropism in the advanced stage of CTCL.
Saphenous Vein Graft Donor Site Dermatitis in Japan
Authors: Kato Naoko , Ueno Hiroo 
Published: April 2015

AbstractFour cases of saphenous vein graft donor site dermatitis are reported from Japan for the first time. The patients were four Japanese men aged from 57 to 69. They noted pruritic eruptions along the lower extremity scar after coronary artery bypass graft surgery using the autogenous saphenous vein. The eruptions appeared mainly on and around the lower end of the venectomy scars from 1.5 to 9 months after graft operations performed at three different hospitals. All four patients showed an objective sensory deficit of the saphenous nerve around the saphenous vein incision scar, although none of them complained of saphenous neuralgia subjectively. Histologically, two patients showed mild epidermal acanthosis, spongiosis, intraepidermal blisters, and perivascular infiltration of lymphocytes and a few eosinophils around dermal blood vessels. The eruption responded well to topical corticosteroids in all cases, although it recurred again in two patients. The entity is characterized by a subacute (belatedly appearing, then slowly disappearing) dermatitis and a mild sensory deficit of the saphenous nerve. Apparently, mild impediment of the saphenous nerve due to an ablational procedure of saphenous venectomy can play a role in causing saphenous vein graft donor site dermatitis.
Measurement of Skin Elastic Properties with a New Suction Device (I): Relationship to Age, Sex and the Degree of Obesity in Normal Individuals
Authors: Ishikawa Takeshi , Ishikawa Osamu , Miyachi Yoshiki 
Published: April 2015

AbstractWe measured skin elastic properties (distension ability, retraction ability, and the skin elasticity) of 4 different body sites, finger, hand, forearm, and chest, in 191 normal individuals by means of a new suction device and investigated the correlation of skin elastic properties with sex, site, age, and the degree of obesity. Neither sex nor the degree of obesity were correlated with skin elastic properties. The skin elastic property of the chest was significantly higher than those of the other three sites. Decrease in the skin elasticity of the hand, forearm and chest were associated with aging. This simple and non‐invasive device can provide an objective method for evaluating skin elastic property.
Increased Serum Level of Interleukin‐6 in Patients with Psoriatic Arthritis and Thrombocytosis
Authors: Yasumoto Shinichiro , Imayama Shuhei , Hori Yoshiaki 
Published: April 2015

AbstractThe role of elevations of serum cytokines in psoriasis is a provocative issue. We report two patients with psoriasis who had episodes of fever, arthritis, and general fatigue. Their symptoms seemed to be associated with increases in serum levels of interleukin (IL)‐6, which paralleled the severity of clinical symptoms as well as elevated serum titers of C‐reactive protein (CRP) and platelet counts. Since IL‐6 is a multipotential cytokine with B‐cell activating, T‐cell activating, and thrombocytopoietic functions, the symptoms and abnormal laboratory findings in these patients may have been related to their increased serum levels of IL‐6. Monitoring the serum level of this cytokine may thus be useful in evaluating the clinical status of patients with psoriatic arthritis.