bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of novel inflammatory markers in stroke-induced immunosuppression
Authors: Folyovich András , Biró Enikő , Orbán Csaba , Bajnok Anna , Varga Viktória , Béres-Molnár Anna K , Vásárhelyi Barna , Toldi Gergely 
Published: March 2014

Abstract

Background
Acute ischemic stroke (AIS) has a biphasic effect on the peripheral immune system. The initial inflammatory response is followed by systemic immunosuppression, referred to as stroke-induced immunosuppression (SIIS), leading to severe complications in stroke patients. We aimed to identify an inflammatory marker that best represents this biphasic immunological response after AIS.

Methods
We investigated the alteration of CRP, WBC, neutrophil count, suPAR levels, CD4+ CD25high Tregs, CD64+ and CD177+ neutrophils and monocytes in 12 acute ischemic stroke patients free of infection within 6 hours and one week after the insult. As controls, 14 age-matched healthy individuals were included.

Results
CRP, WBC and neutrophil count values were comparable in stroke patients within 6 hours and controls, however, they were elevated in stroke one week after the insult. suPAR levels were higher in both stroke groups compared to controls. The prevalence of CD64+ neutrophils was higher in stroke patients within 6 hours than in controls and it decreased in stroke one week after the insult below the level in controls (5.95 [5.41-8.75] % vs. 32.38 [9.21-43.93] % vs. 4.06 [1.73-6.77] %, p < 0.05).

Conclusions
Our pilot study identified that the prevalence of CD64+ neutrophils may reflect a biphasic alteration of the immune response following AIS. Since its level decreases below baseline after one week of the CNS insult in stroke patients without infection, it might serve as a reliable candidate to identify the developing inflammatory response due to infection after stroke in the future.
Acute large-dose exposure to organophosphates in patients with and without diabetes mellitus: analysis of mortality rate and new-onset diabetes mellitus
Authors: Liu Shou-Hsuan , Lin Ja-Liang , Shen Hsin-Lan , Chang Chih-Chun , Huang Wen-Hung , Weng Cheng-Hao , Hsu Ching-Wei , Wang I-Kuan , Liang Chih-Chia , Yen Tzung-Hai 
Published: March 2014

Abstract

Background
We investigated the mortality rates of patients with and without diabetes mellitus after acute large-dose exposure to organophosphate insecticides. All patients without diabetes mellitus were traced to examine the long-term risk of new-onset diabetes mellitus. Previous reports indicated that organophosphate exposure might increase the risk of new-onset diabetes mellitus.

Methods
We analyzed the records of 118 patients referred to Chang Gung Memorial Hospital for management of intentional organophosphate poisoning between 2000 and 2011. Patients were stratified by diabetes mellitus status. Demographic, clinical, laboratory and mortality data were analyzed.

Results
Most patients were middle aged (53.45 ± 16.20 years) and male (65.3%) and were referred to our hospital after a relatively short amount of time had elapsed since poisoning (median 3.0 hours). 18 (15.2%) of 118 patients died, including 15 (13.8%) of 109 patients without diabetes mellitus and 3 (33.3%) of 9 with diabetes mellitus. There was no significant difference in mortality between these groups (P = 0.117). In a multivariate Cox regression model, hypotension (P = 0.000), respiratory failure (P = 0.042), coma (P = 0.023), and corrected QT interval prolongation (P = 0.002) were significant risk factors for mortality. Conversely, diabetes mellitus status was not a significant variable in this model. At routine outpatient follow up a median of 1.25 months post exposure, random blood glucose measurements gave no evidence of new-onset diabetes in patients without pre-existing diabetes.

Conclusions
Diabetes mellitus status might not increase mortality risk following acute large-dose exposure to organophosphates, and the risk of new-onset diabetes mellitus also might be minimal in the short term. Larger prospective studies with formal testing for diabetes at later times post-exposure are required.
Cellular distribution and cytotoxicity of graphene quantum dots with different functional groups
Authors: Yuan Xiaochan , Liu Zhiming , Guo Zhouyi , Ji Yanhong , Jin Mei , Wang Xinpeng 
Published: March 2014

Abstract
Graphene quantum dots (GQDs) have been developed as promising optical probes for bioimaging due to their excellent photoluminescent properties. Additionally, the fluorescence spectrum and quantum yield of GQDs are highly dependent on the surface functional groups on the carbon sheets. However, the distribution and cytotoxicity of GQDs functionalized with different chemical groups have not been specifically investigated. Herein, the cytotoxicity of three kinds of GQDs with different modified groups (NH2, COOH, and CO-N (CH3)2, respectively) in human A549 lung carcinoma cells and human neural glioma C6 cells was investigated using thiazoyl blue colorimetric (MTT) assay and trypan blue assay. The cellular apoptosis or necrosis was then evaluated by flow cytometry analysis. It was demonstrated that the three modified GQDs showed good biocompatibility even when the concentration reached 200 μg/mL. The Raman spectra of cells treated with GQDs with different functional groups also showed no distinct changes, affording molecular level evidence for the biocompatibility of the three kinds of GQDs. The cellular distribution of the three modified GQDs was observed using a fluorescence microscope. The data revealed that GQDs randomly dispersed in the cytoplasm but not diffused into nucleus. Therefore, GQDs with different functional groups have low cytotoxicity and excellent biocompatibility regardless of chemical modification, offering good prospects for bioimaging and other biomedical applications.
Genome-Wide Copy Number Analysis in a Family With p.G533C RET Mutation and Medullary Thyroid Carcinoma Identified Regions Potentially Associated With a Higher Predisposition to Lymph Node Metastasis
Authors: Araujo Aline N. , Moraes Lais , França Maria Inez C. , Hakonarson Hakon , Li Jin , Pellegrino Renata , Maciel Rui M. B. , Cerutti Janete M. 
Published: March 2014

Context:
Our group described a p.G533C RET gene mutation in a large family with multiple endocrine neoplasia type 2 syndrome. Clinical heterogeneity, primarily associated with the presence of lymph node metastases, was observed among the p.G533C carriers.

Objective:
The aim of this study was to use single-nucleotide polymorphism-array technology to identify copy number variations (CNVs), which are present in the constitutional DNA and associated with the established clinical and pathological features of aggressive medullary thyroid carcinoma (MTC), primarily the presence of lymph node metastasis.

Design:
Fifteen p.G533C carriers with MTC were chosen for the initial screening. The subjects were divided into two groups according the presence (n = 8) or absence (n = 7) of lymph node metastasis. Peripheral blood DNA was independently hybridized using a genome-wide single-nucleotide polymorphism Array 6.0 platform. The results were analyzed using both Genotyping Console and PennCNV software. To identify the possible candidate regions associated with the presence of lymph node metastasis, cases (metastatic MTC) were compared with controls (nonmetastatic MTC). The identified CNVs were validated by quantitative PCR in an extended cohort (n = 32).

Results:
Using two different algorithms, we identified nine CNV regions that may contribute to susceptibility to lymph node metastasis. The validation step confirmed that a CNV loss impacting the FMN2 gene was potentially associated with a greater predisposition to lymph node metastasis in this family (P = .0179). Finally, we sought to investigate whether the development of lymph node metastasis might not depend on a single CNV but rather a combination of various CNVs. These analyses defined a CNV pattern related to a more aggressive phenotype in this family, with CNV deletions being enriched in the metastatic group (P = .0057).

Conclusion:
Although hereditable specific RET mutations are important to determine cancer risk, germline CNVs in disease-affected individuals may predispose them to MTC aggressiveness.
Preface
Authors: Mostaghimi Javad 
Published: March 2014

Abstract
The 17th International Symposium on Plasma Chemistry (ISPC 17) was held in Toronto, Ontario, Canada from 7-12 August 2005. ISPC 17 is sponsored by the International Union of Pure and Applied Chemistry (IUPAC) and the International Plasma Chemistry Society (IPCS). This is the second time that the ISPC was held in Canada (ISPC 6, Montreal, Quebec, 1983). Two short courses with 60 participants in low- and high-pressure plasma processing were offered prior to the start of the symposium (4-6 August 2005). A one-day industrial workshop with 63 participants was also held on 7 August 2005.
ISPC is the main symposium on partially ionized gases and plasma processing science. During ISPC 17, 560 researchers, including 183 students, from 48 countries presented their latest discoveries in this field. 540 contributed papers, 5 plenary and 18 invited abstracts covering 15 topics in plasma processing science were presented during the symposium. All submitted abstracts were reviewed by the International Organizing Committee. The complete text of the papers was provided on a searchable CD. The high number of contributed papers and the high level of registration in both the industrial workshop as well as the short courses reflect the continued support and interest of researchers in plasma processing science community in this bi-annual event.
The invited plenary and topical lectures, selected by the International Organizing Committee, are representative of the great progress in the different areas of plasma chemistry. This issue of Pure and Applied Chemistry offers an overview on the recent advances in high- and low-pressure plasmas as well as on more specific developments in plasma processing science. These topics were presented at the ISPC 17 by plenary and topical invited speakers.

Javad Mostaghimi

Conference Chair
Preface
Authors: Yamamoto Yoshinori 
Published: March 2014

Abstract
This volume summarizes the present status of research in the field of organic and inorganic boron chemistry, presented by the invited speakers at the 12th International Meeting on Boron Chemistry (IMEBORON-XII), held in Sendai, Japan, 11-15 September 2005. IMEBORON-XII consisted of 1 plenary lecture, 22 invited lectures, 24 keynote lectures, 48 short oral presentations, and 99 poster presentations. In all, 280 chemists contributed to a truly international meeting, with participants representing China, Czech Republic, Germany, Israel, Japan, Mexico, Poland, Russia, South Korea, Spain, Sweden, the United Kingdom, and the United States.
The presentations at IMEBORON-XII covered all aspects of boron chemistry including theoretical studies, synthetic methods of organic and inorganic boron compounds, novel molecular structures, application of organic and inorganic boron compounds to organic synthesis as catalysts or as reagents, medicinal applications, and creation of new materials (liquid crystals, supramolecular clusters, nanocylinders, molecular electronic devices, nanomachines, ceramics, etc.). Not only the distinguished senior members of the boron community, but also young boron chemists took an active part in the conference. Not only traditional boron chemistry, but also new evolving research areas of boron chemistry were presented. Accordingly, I feel that a new generation of both researchers and research fields is coming in boron chemistry. A selection of the invited contributions to IMEBORON-XII is presented in the 14 papers in this issue.
The importance of scientific exchange in this field was recognized during IMEBORON-XII. Therefore, the continuation of this series of conferences was discussed, and the venue for IMEBORON-XIII in 2008 will be organized by Prof. F. Teixidor at the Institut de Ciencia de Materials de Barcelona, C.S.I.S., Campus U.A.B., Ballaterra, Spain.

Yoshinori Yamamoto

Chairman of IMEBORON-XII
Preface
Authors: Waghorne Earle 
Published: March 2014

Abstract
The series of International Symposia on Solubility Phenomena and Related Equilibrium Processes (ISSP) brings together chemists from a wide range of fields where solubility plays an important role. This variety was well reflected at the 12th ISSP where the plenary and invited lectures included: gas solubilities (Maurer) and gas hydrates (Sloan); solubility limitations to lithium-air batteries (Salomon); studies of solubilities at high pressures (Sawamura); solubility considerations in radioactive waste management (Wanner); kinetics of precipitation and dissolution in hydrothermal systems (Wesolowski); crystal growth and dissolution processes (Koutsoukos); and preferential crystallization (König). Those presented here illustrate this breadth of subject matter and highlight the combination of fundamental and applied research that characterizes this field.
A tradition has developed in the ISSP series of holding a workshop on one topic of particular interest, in parallel with the scientific program. This yearís workshop related to the current state of thermodynamic databases that could be used in understanding and predicting the properties of complex systems, for example, those encountered in constructing waste management facilities. A paper summarizing the workshop discussions is included in this compilation.
The series of Solubility Phenomena grew out of the work of the IUPAC Solubility Data Commission and has been continued through the auspices of IUPAC's Subcommittee on Solubility and Equilibrium Data. The first in this biennial series of meetings was held in 1984 at the University of Western Ontario, and, while subsequent meetings have commonly been held in North America (Newark and Troy) or Europe (Guildford, Moscow, Leoben, Varna, and Aveiro), meetings in Buenos Aires, Hammamet, and Niigata have ensured that all continents have hosted these enjoyable meetings.
The ISSPs are consistently friendly and interesting meetings that bring together scientists and friends from many fields and all parts of the world. The 12th ISSP, held from 23 to 28 July, was entirely in keeping with this tradition with over 100 participants from 30 countries converging on the charming town of Frieberg in Saxony where traditional German hospitality combined with the weather to make a memorable meeting.

Earle Waghorne

Conference Editor
Preface
Authors: Itsuno Shinichi 
Published: March 2014

Abstract
The 12th International Conference on Polymers and Organic Chemistry (POC'06) was held in Okazaki, Japan, from 2-7 July 2006 and was attended by nearly 200 participants from 20 different countries. This was the second time that POC was held in Japan, the first time was in 1990 (1982, Lyon, France; 1984, Lancaster, UK; 1986, Jerusalem, Israel; 1988, Barcelona, Spain; 1990, Kyoto, Japan; 1994, Venice, Italy; 1996, Wroclaw, Poland; 1998, Maa'ale Hachamisha, Israel; 2000, Tianjin, China; 2002, San Diego, USA; 2004, Prague, Czech Republic).
The aim of this series of symposia is to bring together chemists from different chemical fields to define and discuss the most recent developments in the areas of polymer-supported reagents, polymeric catalysts, polymers in medicine and biochemistry, polymers for separations, electro- and light-sensitive functional polymers, polymers for environmental protection, processes within functional polymers, and so on. Plenary lectures were provided by Profs. Yoshio Okamoto (Nagoya University, Japan) and Jean M. J. Fréchet (University of California, Berkeley, USA). Along with the plenary lectures, nine invited lectures featured recent advances in the field of polymer-based chemistry in organic synthesis by David E. Bergbreiter, Kuiling Ding, Shu Kobayashi, Yoon-Sik Lee, Helma Wennemers, Pradeep K. Dhal, Toshihide Inoue, Eiji Yashima, and Peter A. G. Cormack. These lectures, as well as 27 oral presentations of the selected papers, exhibited the strength, diversity, and novelty with which this scientific field is being practiced. In addition, there were 55 poster presentations.
Ten articles contributed by the lecturers and the conference chairs of POC'06 appear in this issue of Pure and Applied Chemistry in order to provide a summary of last summer's conference.

Shinichi Itsuno

POC'06 Co-chair

Yasuhiro Uozumi

POC'06 Co-chair and Conference Editor
Preface
Authors: Toyota Shinji 
Published: March 2014

Abstract
The 12th International Symposium on Novel Aromatic Compounds (ISNA-12) was held in Awaji Island, Japan, on 22-27 July 2007. The IUPAC-sponsored symposium was organized by the local committee, Prof. Yoshito Yobe (Osaka University: chair), Prof. Masahiko Iyoda (Tokyo Metropolitan University: vice-chair), and Prof. Koichi Komatsu (Fukui University of Technology: program chair), and jointly by the Science Council of Japan and the Chemical Society of Japan (CSJ). The symposium was established by Prof. Tetsuo Nozoe in 1970 as the International Symposium on Nonbenzenoid Aromatic Compounds, and this is the third ISNA held in Japan.
The aim of this symposium is to elucidate fundamental principles of synthesis and properties of novel aromatic compounds, and to extend the application of π-conjugated systems in general to a wide area of molecular science. The special topics discussed during the symposium include:
- synthesis of aromatic compounds
- theoretical and structural aspects of aromatic compounds
- supramolecular chemistry of aromatic compounds
- molecular switches and devices
- functions of π-conjugated systems
This symposium was attended by 447 participants from 21 countries and regions worldwide. The scientific program consisted of the Nozoe lecture presented by Prof. François Diederich following the opening ceremony, 12 plenary lectures, 21 invited lectures, 38 oral presentations, and 246 poster presentations. Nineteen articles contributed by the Nozoe lecturer and the plenary and invited lecturers appear in this issue to highlight the recent remarkable progress in this scientific field presented at ISNA-12.
The next symposium, ISNA-13, will be held in Luxembourg on 19-24 July 2009 and organized by Profs. François Diederich and A. Dieter Schlüter (ETH Zürich). ISNA-14 will be organized by Prof. Michael M. Haley (University of Oregon) in the United States in 2011.

Shinji Toyota

Conference Editor
Preface
Authors: Königsberger Erich 
Published: March 2014

Abstract
The 30th International Conference on Solution Chemistry (ICSC 30) was held at Murdoch University, Perth, Western Australia, 16-20 July 2007. Under the proficient chairmanship of Prof. Glenn Hefter, about 100 participants from more than 20 countries from all parts of the world gathered down under not only to discuss science but also to enjoy the relaxed Australian lifestyle and the picturesque scenery surrounding Perth.
A representative selection of the many excellent and timely contributions presented at the Conference is collected in this issue of Pure and Applied Chemistry. This continues a tradition of regular publication coverage of this series over many years, http://www.iupac.org/publications/pac/conferences/ family/ICSC/, and thus enriches a record of ongoing progress in theoretical and experimental solution chemistry. Subjects covered by ICSC 30 include computer modeling of solution structure and dynamics (Hofer, Bowron); simulation of nanocolloidal suspensions (Turq); ion solvation and association (Buchner); polyelectrolyte hydration (Vlachy); aqueous mixtures of hydrophilic and -phobic ions (Kumar); spin-state transitions in solution (Linert); prediction of multiphase chemical equilibria with applications to hydrometallurgy (Eriksson); chemical speciation of polynuclear complexes (Torres); synthesis, solubility, and stability of minerals (Williams); ternary mixtures involving ionic liquids (MacFarlane); and structure of biological macromolecules in mixed solvents (Yamaguchi). The Conference Editor wishes to thank all authors for their contributions to this issue.
The 31st International Conference on Solution Chemistry will be organized by Prof. Bernd M. Rode, Dr. Bernhard Randolf, and Dr. Thomas Hofer in Innsbruck, Austria, 21-25 August 2009 (http://icsc2009.org/).

Erich Königsberger

Conference Editor
Preface
Authors: Lee Sang-gi 
Published: March 2014

Abstract
The 17th International Conference on Organic Synthesis (ICOS 17) was held in Daejeon, Korea during 22-27 June 2008 under the joint chairmanship of Prof. Eun Lee (Seoul National University) and Prof. Sunggak Kim (Korean Advanced Institute of Science and Technology). Professor Sung Ho Kang (Korean Advanced Institute of Science and Technology) acted as Chair of the Organizing Committee for the event, which is the latest in a regular biennial series that was initiated in 1974 under the auspices of IUPAC. On this occasion, the Korean Chemical Society acted as cosponsors, and the Conference enjoyed generous financial support from the Korean Research Foundation, the Korean Federation of Science and Technology Societies, and a sponsorship club representing Korean industries.
Almost 1000 participants, including 412 foreign scientists, attended from 32 countries, once again demonstrating the ongoing international appeal and topicality of organic synthesis. The scientific program of ICOS 17 was characterized by in-depth coverage of many familiar aspects of the topic, such as synthetic methodology, natural products synthesis, bioorganic chemistry, chemical biology, organic materials, and medicinal chemistry. The program was delineated in five broad themes entitled:
- Discovery of new reagents and reactions
- Challenges and new trends in natural products synthesis
- Prospects in bioorganic chemistry and chemical biology
- Visions in organic materials researches
- Events in drug discovery and process development
A total of 51 invited lectures were delivered; in addition to 36 from academia, 13 emanated from industry and 2 from research institutes. A highlight of the lecture program was the Thieme-IUPAC prize lecture presented by Prof. Dean Toste (University of California, Berkeley, USA). The poster program was particularly well supported, and no less than 533 posters were presented during two sessions.
This issue of Pure and Applied Chemistry comprises a collection of 12 papers based on lectures delivered at ICOS 17. The organizers are particularly grateful to all who contributed to this issue for their timely efforts. The topics of these papers feature some of the major themes of the conference and thus furnish a representative insight into the scientific program and capture exciting new developments and trends. This series will continue in Bergen, Norway on 2-5 August 2010, and it is confidently expected that it will continue to fulfill an important scientific role in highlighting ongoing advances in modern organic synthesis.

Sang-gi Lee

Conference Editor