bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimized Fine-Tuning of Large Language Model for Better Topic Categorization with Limited Data
Authors: Vulpescu Elena , Beldean Mihai 
Published: July 2024

Abstract

The novel approach of fine-tuning the Llama model for topic categorization with limited data presents significant advancements, offering enhanced performance and reduced hallucinations compared to traditional models. Employing transfer learning and data augmentation techniques, the research demonstrates the model's ability to adapt to diverse thematic domains, achieving high accuracy in topic categorization. Comprehensive comparative analysis with baseline models demonsrates the superiority of the fine-tuned Llama model, highlighting the effectiveness of advanced training methodologies and hyperparameter optimization strategies. Additionally, the analysis of hallucinations illustrates the robustness of implemented mitigation techniques, thereby enhancing the reliability of generated text. Computational efficiency assessment confirms the practical feasibility of deploying the fine-tuned model, balancing resource utilization with performance gains. The study substantiates the potential of large language models to be fine-tuned effectively for specialized tasks, contributing valuable insights to the field of natural language processing.
A Cosine-X Generalized Inverted Weibull Distribution: Properties and Applications
Authors: OSI Abdulhameed Ado , Dahiru Dahiru Abdullahi , Shuaibu Ahmed , Abubakar Usman 
Published: July 2024

Abstract

A new extension of the three-parameter Generalized Inverted Weibull Distribution, called the Cosine-X Generalized Inverted Weibull (CGIWD) distribution, is proposed in this study. Several statistical properties of the distribution, such as moments, moment generating function, quantile function, Renyi entropy, and the distribution of order statistics, were investigated. Maximum Likelihood Estimation (MLE) was used to estimate the model parameters, and a simulation study was conducted to assess the behavior of the estimates. Additionally, we demonstrate the applicability of the proposed distribution, three real datasets were used. The results indicate that CGIWD performed better than competing distributions in fitting two of the real datasets.
Kumaraswamy Sine Inverted Rayleigh distribution : Properties and Application to Bladder Cancer Data
Authors: OSI Abdulhameed Ado , Abubakar Usman , Ringim Muftahu Zubairu 
Published: July 2024

Abstract

In this work, we propose the Kumaraswamy Sine Inverted Rayleigh distribution (KWSIR) as an improved version of the classical inverse Rayleigh distribution. The KWSIR distribution combines the Kumaraswamy and Sine Inverted Rayleigh distributions to provide better fits for real datasets. It is characterized by a unimodal and right-skewed probability density function, as well as an increasing and J-shaped hazard rate function. We explore various characteristics of this distribution, such as the probability density function, cumulative distribution function, quantile function, moments, incomplete moments entropy measures, and order statistics. The model parameters are estimated using maximum likelihood. Additionally, we demonstrate specific applications and provide examples to illustrate the flexibility and fitting capabilities of the model for real-world datasets
2010 Mathematics Subject Classification. 26A25; 26A35.
Dispersão de vírus zoonóticos de alta patogenicidade para humanos por morcegos
Authors: Gorgonho Paulo Henrique 
Published: July 2024

O presente estudo construído de através da literatura especifica relacionada ao tema tem como objetivo central a ampliação do conhecimento das consequências da convivência entre seres humanos e morcegos, tendo como objetivo principal realizar a descrição sob o ponto de vista clínico-laboratorial os vírus zoonóticos de maior grau de patogenicidade para humanos que são dispersados por estes animais, e como objetivos secundários, realizar o apontamento dos fatores associados à transmissão de zoonoses, com ênfase à aquelas que tenham alto taxa de mortalidade, pelos morcegos aos humanos, enumerar os principais vírus zoonóticos de alta patogenicidade que são dispersados por morcegos, e relatar os aspectos clínico-laboratoriais dos principais vírus zoonóticos. Ademais correlacionar eventos ocorridos em diversas partes do mundo a situação brasileira, com intuito de apontar a possibilidade da dispersão de vírus zoonóticos de alta patogenicidade no país. Em suma o estudo apresentou logrou êxito em ampliar os conhecimentos sobre os objetivos propostos.
Scaling up the practice of water operators’ partnership (WOP) and its linkages with investment programmes
Authors: Pascual-Sanz Maria , Diaz Carlos , Volk Franziska 
Published: July 2024

ABSTRACT
Funding is limiting the extent to which water operators can engage in helping one another to increase access to water and sanitation services. Besides capacity development support, Water Operators' Partnerships are increasingly supporting mobilisation, implementation and sustainability of investment programmes. This paper aims to deepen the understanding of the current funding scenario for Water Operators` Partnerships, identify obstacles, and explore possibilities to promote the mobilisation of additional funds. It does so by analysing costs, sizes, sources of funding and the co-existence of WOPs with investment programmes. Some significant findings include the increasing recognition of the positive influence of WOPs not only by donors but also by development financial institutions, the emergence of WOP-dedicated programmes, the great potential of funds coming from decentralised development funding mechanisms, and the multiple scenarios in which WOPs and investment programmes co-exist. Salient challenges are the low reach of information related to WOP outcomes and the low feasibility of WOPs being funded by the technical assistance component of investment programmes. A remarkable highlight is the invitation from development financial institutions to WOP proponents to join forces in identifying ways to secure the best alignment and synergies between WOP support and investment programmes.
Virtual Screening of Indonesian Herbal Compounds with Neuraminidase Inhibitor Activity against N2 Influenza Virus Protein: An in silico Study
Authors: Nurjanah Diana , Fadilah Fadilah , Dharmayanti Ni Luh Putu Indi 
Published: July 2024

Background: Neuraminidase inhibitor (NAI) is one of anti-influenza drugs recommended for use by the World Health Organization (WHO). However, after treatment with NAI drugs in human, resistance to influenza antiviral drugs is begun to rise. Therefore, identification of compounds from Indonesian herbal plants as natural inhibitors of the influenza virus neuraminidase protein needs to be conducted for the development of new anti-influenza drugs.Materials and methods: The crystal structure of the neuraminidase protein complex used in this study was obtained from the Protein Data Bank (PDB). Structure-based pharmacophore modeling was performed using LigandScout version 4.4.5 software. Indonesian herbal plant compounds were collected from the HerbalDB database. Protein and ligand processing was carried out using Autodock 4.2 software. The 3D interaction visualization was carried out with Autodock software, while 2D interaction visualization was carried out with LigPlot software. To determine the toxicity and drug-likeliness of the ligand, the test ligands that had the best docking results were predicted using SwissADME and AdmetSAR.Results: From the virtual screening results, 24 hits were found, and five compounds had the best binding energy among the 24 tested compounds, these were pollenitin (ΔG=-7.22 kcal/mol), OPC-4:0 (ΔG=-7.11 kcal/mol), 6-hydroxykaempferol (ΔG=-7.08 kcal/mol), 5,8-dihydroxy-7,4'-dimethoxyflavone (ΔG=-7.07 kcal/mol), and 3,5,6,7-tetrahydroxy-4'-methoxyflavone (ΔG=-6.95 kcal/mol). The best five compounds were then chosen for further analysis.Conclusion: OPC-4:0 is found to be the best compound for the NAI based on its binding energy, pharmacokinetics, toxicity, and drug-likeliness. Thus, OPC-4:0 might be a potential candidate as a NAI of HxN2 virus. Keywords: influenza, molecular docking, neuraminidase, resistance, virtual screening
Trajectory Analysis for Identifying Classes of Attention Deficit Hyperactivity Disorder (ADHD) in Children of the United States
Authors: Lee Yu-Sheng , Sprong Matthew Evan , Shrestha Junu , Smeltzer Matthew P. , Hollender Heaven 
Published: July 2024

Background
Attention Deficit Hyperactivity Disorder (ADHD) is a mental health disorder that affects attention and behavior. People with ADHD frequently encounter challenges in social interactions, facing issues, like social rejection and difficulties in interpersonal relationships, due to their inattention, impulsivity, and hyperactivity.

Methods
A National Longitudinal Survey of Youth (NLSY) database was employed to identify patterns of ADHD symptoms. The children who were born to women in the NLSY study between 1986 and 2014 were included. A total of 1,847 children in the NLSY 1979 cohort whose hyperactivity/inattention score was calculated when they were four years old were eligible for this study. A trajectory modeling method was used to evaluate the trajectory classes. Sex, baseline antisocial score, baseline anxiety score, and baseline depression score were adjusted to build the trajectory model. We used stepwise multivariate logistic regression models to select the risk factors for the identified trajectories.

Results
The trajectory analysis identified six classes for ADHD, including (1) no sign class, (2) few signs since preschool being persistent class, (3) few signs in preschool but no signs later class, (4) few signs in preschool that magnified in elementary school class, (5) few signs in preschool that diminished later class, and (6) many signs since preschool being persistent class. The sensitivity analysis resulted in a similar trajectory pattern, except for the few signs since preschool that magnified later class. Children’s race, breastfeeding status, headstrong score, immature dependent score, peer conflict score, educational level of the mother, baseline antisocial score, baseline anxious/depressed score, and smoking status 12 months prior to the birth of the child were found to be risk factors in the ADHD trajectory classes.

Conclusion
The trajectory classes findings obtained in the current study can (a) assist a researcher in evaluating an intervention (or combination of interventions) that best decreases the long-term impact of ADHD symptoms and (b) allow clinicians to better assess as to which class a child with ADHD belongs so that appropriate intervention can be employed.
Urinary continence following extraperitoneal radical prostatectomy: impact of surgical technique and pelvic fascial spaces reconstruction
Authors: Chibichyan M. B. , Kogan M. I. , Belousov I. I. , Sizyakin D. V. , Avetyan A. V. , Trusov P. V. , Shkodkin S. V. , Pchelkin A. S. 
Published: July 2024

Introduction. Urinary incontinence is a common complication of radical prostatectomy. The development of surgical techniques when performing radical prostatectomy that improve the function of urinary continence after surgery is actual.Objective. To compare urinary continence functions in long-term follow-up after open and laparoscopic radical prostatectomy when only posterior or combined (anterior + posterior) reconstruction of the pelvic fascial spaces is performed.Materials & methods. The study included 130 patients aged 63.0 [59.0; 68.0] years with local prostate cancer (сT1a-2сN0-xM0; 1 – 4 ISUP groups), subjected to non-nerve-sparing retropubic radical prostatectomy with posterior reconstruction and non-nerve-sparing extraperitoneal laparoscopic radical prostatectomy with isolated posterior or combined (anterior + posterior) fascial reconstruction of the pelvic fascial spaces. Postoperative continence function was studied at 1, 3, 6, and 12 months following surgery using a standard pad test.Results. The incidence of urinary continence was higher at all follow-up periods during laparoscopic surgery. From the 6-months follow-up, these patients did not have severe urinary incontinence. At the same time, the rate of growth of some patients who began to retain urine did not depend on the method of reconstruction of the pelvic fascial spaces. The use of combined reconstruction of the pelvic fascial spaces at 12-months follow-up showed an advantage in urinary continence over performing only posterior reconstruction. Such patients achieved urinary continence in 90% of cases compared to 80.0% of cases. At the same time, the restoration of urinary continence at all periods of observation had a relatively uniform linear rate of increase in the indicator.Conclusion. Reconstruction of the pelvic fascial spaces during open and laparoscopic radical prostatectomy allows one to achieve satisfactory continuation in the postoperative period. However, higher efficiency is achieved when using a combined reconstruction technique.
Evaluation of the efficacy of Vesusten® in patients with overactive bladder and chronic recurrent cystitis
Authors: Galkina N. G. , Galkin A. V. 
Published: July 2024

Introduction. Numerous studies have suggested that lower urinary tract infections may be involved in the development of overactive bladder (OAB) in patients who are resistant to standard treatment. In these cases, treatment targeting all stages of disease progression could be beneficial.Objective. To evaluate the efficacy of Vesusten® in management of OAB in women with chronic recurrent cystitis.Materials & methods. The study involved 40 patients diagnosed with OAB and chronic recurrent cystitis. All patients received Vesusten® as therapy for OAB. They received 5 mg of the medication intramuscularly three times per week for a total of 10 doses. The study included three stages: a screening period lasting up to 14 days; the stage for assessing the effectiveness of therapy (42 days from the start of therapy, including the therapy period + further follow-up after the end of therapy); follow-up period — 180 days + 14 days from completion of treatment.Results. It was revealed Vesusten® clinical effectiveness on the severity of OAB symptoms and the quality of life of patients. hree weeks after the end of treatment, there was a statistically significant decrease in the severity of OAB symptoms on the Patient Perception Index of Urgency and Symptoms (PPIUS) (2.2 ± 1.0 vs 0.95 ± 1.0 points) and TUFS (28.4 ± 11.6 vs 5. 1 ± 6.4 points), a decrease in the number of urinations during the day (11.5 ± 2.2 vs 8.8 ± 2.7 episodes) and at night (3.5 ± 1.8 vs 1.4 ± 1.5 episodes) time (p < 0.001). The nighttime urination frequency decreased by more than 2.5 times, while the proportion of patients who did not wake up at night for urination increased from 10 % to 35%. Evaluation of the Overactive Bladder Questionnaire (OAB-Q) after the completion of treatment compared with the initial data showed a statistically significant improvement in quality of life related to the severity of OAB symptoms (24.8 ± 7.5 vs 15.7 + 6.4 points; p < 0.001), and with general health status (74.0 ± 31.7 vs 57.6 ± 22.1 points; p = 0.0087). The average duration of the relapse-free period, including the course of Vesusten® treatment and the follow-up period, significantly increased to 42.90 ± 9.64 weeks in comparison with the duration of the relapse-free period before patients’ inclusion in the study — 17.96 ± 7.75 weeks (p < 0.001). During the clinical study, eight women experienced exacerbations of chronic cystitis (20%).Conclusion. Study results suggest that the drug Vesusten® may be an effective treatment for OAB in combination with chronic recurrent cystitis. Based on our findings, we believe that Vesusten® can be considered as a potential treatment option for patients with chronic cystitis.
Transposition of the distal urethra: 10-year treatment results
Authors: Gvozdev G. Yu. , Bryanskykh E. P. , Sazonova N. A. , Lazareva E. K. , Sarukhanian A. L. 
Published: July 2024

Introduction. Post-coital cystitis is not a separate nosologic unit, but belongs to recurrent urinary tract infection. Surgical interventions are only recommended in cases where conservative treatment fails to provide relief.Objective. To evaluate the results of post-coital cystitis prophylaxis in urethral transposition.Materials & methods. A retrospective study of 46 patients who underwent surgical treatment in the volume of transposition of the distal urethra from 2011 to 2013 was conducted in the clinic of Urology of MSUMD based on the Spasokukotsky Moscow Clinical Hospital.Results. Based on subjective reports from patients, urethral transposition was found to be effective in 71.7% of cases. Half of the participants reported no recurrence of cystitis within the past year, and over half (67%) reported no inflammatory episodes after undergoing surgery.Conclusion. The findings suggest that urethral transposition is an effective and relatively safe treatment option for patients with post-coital cystitis who have failed to respond to conservative treatments.
Comparison of thulium and holmium lasers with conventional transurethral bladder resection for non-muscle invasive bladder cancer
Authors: Popov S. V. , Huseynov R. G. , Pomeshkin E. V. , Scriabin O. N. , Sivak K. V. , Perepelitsa V. V. , Lelyavina T. A. , Malyshev E. A. 
Published: July 2024

Introduction. The gold standard of treatment for intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC) is transurethral resection of the bladder (TURB) in combination with intravesical therapy. However, this procedure may cause serious complications. At the same time, studies of various lasers for the treatment of NMIBC have demonstrated their safety and efficacy. Despite this, the topic has not yet been fully explored and is not widely practiced in clinical oncology, making further research necessary.Objective. To compare thulium and holmium lasers with conventional TURB for management of non-muscle-invasive bladder cancer (NMIBC).Materials & methods. In our study, depending on the treatment approach, 84 NMIBC-patients were divided into three groups. Group 1 included 27 patients (34.14%), who underwent laser thulium bladder resection; group 2 included 25 patients (29.76%), who underwent laser holmium bladder resection, and group 3 included 32 patients (38.1%), who underwent standard TURB. Prior to surgery, all patients received a standard set of preoperative general clinical and instrumental examinations for bladder cancer, and the choice of surgical approach was based on informed patient consent, taking into account the benefits and risks of the three treatment options. All surgeries were performed in accordance with established protocols.Results. In the TURB group, the surgery time was the longest and totalled in 20.5 ± 7.4 min. Laser technologies reduce the surgery time to 16.3 ± 5.3 min for a holmium laser and to 14.7 ± 5.2 min for a thulium laser. Also, in groups 1 and 2, a shorter duration of postoperative bladder irrigation was noted (4.4 ± 1.8 and 4.7 ± 1.6 hours) and shorter periods of postoperative bladder catheterisation (1.5 ± 0.08 and 1.6 ± 0.08 days) compared to group 3, where these indicators were 16.4 ± 2.5 hours and 2.5 ± 0.13 days, respectively. Among patients undergoing either holmium or thulium surgery, a higher rate of disease-free survival has been noted. Independent prognostic factors that influence the prognosis of NMIBC in all groups include the type of surgery, history of bladder tumors, and pathological stage.Conclusion. The use of laser technology, such as thulium and holmium laser, in bladder wall resection for NMIBC shows promising results and provides a good clinical outcome that is comparable to (and in some cases, superior to) standard TURB.
Patterns of Use and Withdrawal Syndrome in Dual Cannabis and Tobacco Users (DuCATA_GAM-CAT): Protocol for a Mixed Methods Study
Authors: Saura Judith , Feliu Ariadna , Enríquez-Mestre Marta , Fu Marcela , Ballbè Montse , Castellano Yolanda , Pla Margarida , Rosa Nathalia , Radeva Petia , Maestre-González Elena , Cabezas Carmen , Colom Joan , Suelves Josep M , Mondon Silvia , Barrio Pablo , Andreu Magalí , Raich Antònia , Bernabeu Jordi , Vilaplana Jordi , Roca Tutusaus Xavier , Guydish Joseph , Fernández Esteve , Martínez Cristina 
Published: July 2024

Background
Approximately 1 in 6 cannabis users develop a cannabis use disorder (CUD) and the odds increase to 1 in 2 for daily users.

Objective
The Dual use of Cannabis and Tobacco Monitoreing through a Gamified Web app (DuCATA_GAM-CaT) project aims to identify cannabis-tobacco patterns of use and withdrawal symptoms among individuals with CUD who are attending substance abuse programs.

Methods
The project uses a mixed methods approach consisting of 3 studies. First, a participatory qualitative study involves focus groups comprising individuals with CUD, clinicians, project researchers, and an expert gamification company to co-design a gamified web app. Second, a longitudinal prospective study to follow up individuals over 6 weeks with CUD attending substance abuse programs . Participants report their cannabis-tobacco usage patterns, type and frequency of tobacco use, nicotine dependence, withdrawal symptoms, psychoemotional factors, and motivation to quit both substances. Predictive analysis techniques are used to analyze clinical, demographic, psychological, and environmental data to predict the probability of achieving abstinence. Third, homogeneous focus groups to explore participants’ experiences during their CUD treatment.

Results
By June 2024, the project had completed the first study, defining eligible cannabis user profiles, developed the initial web app prototype, and initiated recruitment across 10 centers, with 74 participants enrolled, aiming to reach 150 participants in total.

Conclusions
All participants are required to provide informed consent, and their information is kept confidential and anonymized following confidentiality rules. The research team is committed to disseminating the results obtained to professional and patient groups, as well as informing public health agents, to positively influence political and social decision makers and design programmers. Additionally, we aim to prioritize the publication of the results in high-impact journals specialized in drug abuse, public health, and health care services research.

Trial Registration
ClinicalTrials.gov NCT05512091; https://clinicaltrials.gov/study/NCT05512091

International Registered Report Identifier (IRRID)
DERR1-10.2196/58335
Coaching clinic research proposal writing: A practical guide to your research success
Authors: Hardani H. , Sahbany Sri , Hadi Samsul , Ulandari Atri Sri , Ariwidiani Ni Nyoman , Supinganto Agus 
Published: July 2024

Writing a research proposal is a crucial first step in determining the success of your research project. However, authors often face challenges in formulating proposals that are clear, relevant, and persuasive. The purpose of this service is to help researchers, especially young researchers in making research proposals. The method of implementing this service uses a Coaching Clinic, discussion, and mentoring which is carried out in a hybrid manner with pre-test and post-test. Participants in this Coaching Clinic were young lecturers from Politeknik Medica Farma Husada Mataram and several other universities who participated online. There were 20 participants and it was held online through a Zoom meeting on December 16, 2023. The main target of this activity is young lecturers who have minimal experience writing research proposals. The results of this service show an increase in lecturers' abilities or skills and understanding in writing research proposals by 84.50%. Coaching clinics can improve the ability of lecturers to write research proposals.