bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrophilized Silicone Matrix for the Preparation of Stable Carbonyl Reductase Immobilizates
Authors: Scholz Alexander , Eckstein Marrit , Ansorge‐Schumacher Marion B. 
Published: February 2013

AbstractIndustrial use of enzymes requires high activity, stability, and manageability under technical conditions. Therefore, most biocatalysts are immobilized before use, often by physical adsorption onto a solid carrier. However, a major limitation for the technical use of such immobilizates is the insufficient operational stability under process conditions resulting from enzyme leaching and carrier disintegration. Our group demonstrated recently that for lipase‐catalyzed esterifications these limitations can be largely overcome by the formation of silCoat biocatalysts, composite materials of carrier‐bound enzymes and silicone. Here, we report the successful transformation of this method to the immobilization of carbonyl reductase (CR), an enzyme representing oxidoreductases as a completely different class of biocatalysts. The silCoat biocatalysts cannot be transferred directly to CR because they require an overall hydrophilic surrounding, which opposes the hydrophobicity of silicone. Consequently, the hydrophilization of the material is necessary to achieve reasonable enzyme activity. This was realized by the rational modification of the precursors for silicone formation and applied to increase the leaching stability and mechanical strength of the carrier‐bound CR. The resulting HYsilCoat CR had a significantly longer half‐life than that obtained through the uncoated preparation; the mechanical stability of an alumina carrier was increased by a factor of 120. This enables the consideration of mechanically unstable but environmentally friendly and/or cheap material as an enzyme carrier for industrial use.
Phthalocyanine‐Sensitized Graphene–CdS Nanocomposites: An Enhanced Photoelectrochemical Immunosensing Platform
Authors: Li Yong‐Jie , Ma Meng‐Jie , Yin Gui , Kong Yong , Zhu Jun‐Jie 
Published: February 2013

AbstractA novel strategy is developed for the fabrication of graphene–CdS (G–CdS) nanocomposites by in situ growth of CdS nanoparticles onto simultaneously reduced graphite oxide, which is noncovalently functionalized by sodium 1‐pyrene sulfonate through strong π–π stacking interactions. Subsequently, cobalt 2,9,16,23‐tetraaminophthalocyanine (CoTAPc) is self‐assembled on the G–CdS nanocomposites through electrostatic interactions to produce phthalocyanine‐sensitized G–CdS nanocomposites. The photoactive superstructure enhances the photocurrent generation capability, and presents an efficient photoelectrochemical immunosensing platform for the ultrasensitive detection of the prostate‐specific antigen (PSA). The quantitative measurement of PSA is based on the decrease in the photocurrent intensity of the phthalocyanine‐sensitized G–CdS nanocomposites, which results from an increase in the steric hindrance due to the formation of the immunocomplex. A linear relationship between the photocurrent decrease and the PSA concentration is obtained in the wide range from 1 pg mL−1 to 5 μg mL−1 with a detection limit of 0.63 pg mL−1. The proposed sensor shows high sensitivity, stability, reproducibility, and can become a promising platform for other biomolecular detection.
Multifunctional Core‐Shell‐Corona‐Type Polymeric Micelles for Anticancer Drug‐Delivery and Imaging
Authors: Bastakoti Bishnu Prasad , Wu Kevin C.‐W. , Inoue Masamichi , Yusa Shin‐ichi , Nakashima Kenichi , Yamauchi Yusuke 
Published: February 2013

AbstractWe have developed core‐shell‐corona‐type polymeric micelles that can integrate multiple functions in one system, including the capability of accommodating hydrophobic dyes into core and hydrophilic drug into the shell, as well as pH‐triggered drug‐release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution. The mineralization of calcium phosphate (CaP) on the PAA domain not only enhances the diagnostic efficacy of organic dyes, but also works as a diffusion barrier for the controlled release.
ChemInform Abstract: A Six‐Connected 3‐D Framework [enH2]2[Cu(en)2]3 [H2W12O42]·6H2O Constructed from Paratungstate‐Based Polyoxometalate Units.
Authors: Li Yuye , Leng Chunli , Zhao Junwei , Chen Sudi , Ma Pengtao , Chen Lijuan 
Published: February 2013

AbstractThe title compound is hydrothermally synthesized from a mixture of CuCl2, Na2WO4, en, AcOH, and H2O (pH 8.5, 100 °C, autoclave, 7 d; 25% yield).
ChemInform Abstract: Palladium‐Catalyzed C(sp2)—H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source.
Authors: Peng Jiangling , Zhao Jiaji , Hu Ziwei , Liang Dongdong , Huang Jinbo , Zhu Qiang 
Published: February 2013

AbstractMechanistic studies indicate a tertiary carbon cation to be an intermediate.
ChemInform Abstract: Copper(I) Hydroxyapatite Catalyzed Sonogashira Reaction of Alkynes with Styrenyl Bromides. Reaction of cis‐Styrenyl Bromides Forming Unsymmetric Diynes.
Authors: Saha Debasree , Chatterjee Tanmay , Mukherjee Manabendra , Ranu Brindaban C. 
Published: February 2013

AbstractTreatment of trans‐styrenyl bromides with alkynes under conditions A) provides a convenient approach to the expected trans‐enynes.
ChemInform Abstract: Copper(II) Triflate‐Catalyzed Reduction of Carboxylic Acids to Alcohols and Reductive Etherification of Carbonyl Compounds.
Authors: Zhang Yin‐Jie , Dayoub Wissam , Chen Guo‐Rong , Lemaire Marc 
Published: February 2013

AbstractThe procedure to reduce the carboxylic acids, aldehydes and ketones using TMDS as a reducing agent and Cu(OTf)2 as a catalyst is developed.
ChemInform Abstract: Ethylenediamine Diacetate (EDDA) Mediated Synthesis of Aurones under Ultrasound: Their Evaluation as Inhibitors of SIRT1.
Authors: Manjulatha Khanapur , Srinivas S. , Mulakayala Naveen , Rambabu D. , Prabhakar M. , Arunasree Kalle M. , Alvala Mallika , Rao M. V. Basaveswara , Pal Manojit 
Published: February 2013

AbstractAn improved synthesis of functionalized aurones is achieved via reaction of benzofuranones, e.g. (I) with benzaldehydes such as (II) in the presence of a mild base under ultrasound.
ChemInform Abstract: Palladium‐Catalyzed Direct Arylation Using Free NH2 Substituted Thiophene Derivatives with Inhibition of Amination Type Reaction.
Authors: Derridj Fazia , Larbi Karim Si , Roger Julien , Djebbar Safia , Doucet Henri 
Published: February 2013

AbstractThe novel procedure for the direct arylation of the thiophene derivatives bearing a free amino group using aryl and heteroaryl bromides and iodides is developed.
ChemInform Abstract: Aerobic Palladium(II)‐Catalyzed Dehydrogenation of Cyclohexene‐1‐carbonyl Indole Amides: An Indole‐Directed Aromatization.
Authors: Kandukuri Sandeep R. , Oestreich Martin 
Published: February 2013

AbstractIn the presence of O2, PivOH, Pd(OAc)2, and methyl nicotinate cyclohexenes of type (I) and (IV) are found to undergo unexpected aromatization to afford N‐benzoylindoles like (II) and (V).
ChemInform Abstract: Synthesis of 3‐Substituted 4‐Alkoxyisoquinolin‐1‐amines by the Reactions of 2‐[Alkoxy(lithio)methyl]benzonitriles with Nitriles.
Authors: Kobayashi Kazuhiro , Matsumoto Kota , Ezaki Kosuke 
Published: February 2013

AbstractA direct and general preparation of the title isoquinolines (III) and (V) is accomplished in a one‐pot fashion using lithiated (alkoxymethyl)benzonitriles.
ChemInform Abstract: A Facile One‐Pot Synthesis of Functionalized Thiazines in Water.
Authors: Rostami‐Charati Faramarz , Hossaini Zinatossadat , Moghimi Masoumeh , Kowsari Elaheh 
Published: February 2013

AbstractA simple procedure allows the synthesis of thiazine derivatives by a three‐component reaction.
ChemInform Abstract: A One‐Pot Approach to the Synthesis of Triazolobenzothiadiazepine 1,1‐Dioxide Derivatives by Basic Alumina‐Supported Azide—Alkyne [3 + 2] Cycloaddition.
Authors: Majumdar K. C. , Ganai Sintu , Sinha Biswajit 
Published: February 2013

AbstractSynthesis of title compounds is achieved by the present new reaction of substituted benzenesulfonamides (I) with various propargyl bromides in basic alumina under microwave irradiation.
ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate‐Binding Angiogenic Growth Factors.
Authors: Liu Ligong , Li Caiping , Cochran Siska , Feder Daniel , Guddat Luke W. , Ferro Vito 
Published: February 2013

AbstractSmall molecule heparan sulfate mimetics like (VI) and (X) are synthesized by the Ugi four‐component condensation of mannopyranoside‐derived isocyanides (I) and (VII) with a variety of carboxylic acids, e.g.(II), amines such as (III) and (VIII), and formaldehyde (IV) as the carbonyl component, followed by sulfonation.
ChemInform Abstract: The Direct Synthesis of Pure Zeolite‐A Using “Virgin” Kaolin.
Authors: Holmes Stuart M. , Alomair Abdulaziz A. , Kovo Abdul S. 
Published: February 2013

AbstractNigerian kaolin is converted into pure zeolite‐A by calcination of the kaolin at 650 °C for ten minutes, followed by mixing the obtained metakaolin with a zeolite seed, NaOH, and H2O (autoclave, 100 °C, 3 h).
A compartmental model of neuropeptide circulation and capture between the axon soma and nerve terminals
Authors: Kuznetsov I.A. , Kuznetsov A.V. 
Published: February 2013

SUMMARYThis paper is motivated by a recent experimental research by Levitan and colleagues (Wong MY, Zhou C, Shakiryanova D, Lloyd TE, Deitcher DL, Levitan ES. Neuropeptide delivery to synapses by long‐range vesicle circulation and sporadic capture. Cell 2012; 148(5): 1029–1038), which discovered and explained the circulation of dense core vesicles (DCVs) between the neuron soma and nerve terminals. We developed a compartmental mechanistic model to simulate this circulation. The model includes five compartments, the axonal compartment and four en passant boutons, which are small axonal varicosities that are present in many axon terminals. By postulating expressions for DCV fluxes between the compartments and for the rates of DCV capture in the boutons and utilizing conservation of DCVs, ODEs modeling concentrations in each of the compartments were developed. The equations were then solved numerically. The obtained results provide insight into how DCV circulation develops, what the circulation is at steady state, and how it may be affected by defects in retrograde transport. Copyright © 2013 John Wiley & Sons, Ltd.
Mesoporous Fluorocarbon‐Modified Silica Aerogel Membranes Enabling Long‐Term Continuous CO2 Capture with Large Absorption Flux Enhancements
Authors: Lin Yi‐Feng , Chen Chien‐Hua , Tung Kuo‐Lun , Wei Te‐Yu , Lu Shih‐Yuan , Chang Kai‐Shiun 
Published: February 2013

AbstractThe use of a membrane contactor combined with a hydrophobic porous membrane and an amine absorbent has attracted considerable attention for the capture of CO2 because of its extensive use, low operational costs, and low energy consumption. The hydrophobic porous membrane interface prevents the passage of the amine absorbent but allows the penetration of CO2 molecules that are captured by the amine absorbent. Herein, highly porous SiO2 aerogels modified with hydrophobic fluorocarbon functional groups (CF3) were successfully coated onto a macroporous Al2O3 membrane; their performance in a membrane contactor for CO2 absorption is discussed. The SiO2 aerogel membrane modified with CF3 functional groups exhibits the highest CO2 absorption flux and can be continuously operated for CO2 absorption for extended periods of time. This study suggests that a SiO2 aerogel membrane modified with CF3 functional groups could potentially be used in a membrane contactor for CO2 absorption. Also, the resulting hydrophobic SiO2 aerogel membrane contactor is a promising technology for large‐scale CO2 absorption during the post‐combustion process in power plants.
Asymmetric Synthesis of Two Analogues of Meiogynin A
Authors: Dardenne Jérémy , Desrat Sandy , Guéritte Françoise , Roussi Fanny 
Published: February 2013

AbstractThe efficient and asymmetric synthesis of two analogues of meiogynin A, a natural sesquiterpenoid dimer that was recently isolated by our group, is reported. The key reaction was a highly selective intermolecular Diels–Alder reaction between an aromatic triene and two chiral dienes. This convergent synthesis maximizes the atom economy concept, as the expected compounds were obtained in only eight steps without any protecting groups.
A Telescoping Synthesis of Chimeric Polyheterocycles through a Piperidine‐Mediated Multicomponent Reaction
Authors: Lee Chia‐Hsin , Hsu Wei‐Shun , Chen Chih‐Hau , Sun Chung‐Ming 
Published: February 2013

AbstractA new piperidine‐catalyzed Groebke–Bienaymé–Blackburn (GBB) multicomponent reaction of 2‐aminobenzimidazoles, methyl 2‐formylbenzoate, and isocyanides has been explored. A facile and straightforward postmodification leads to isoquinolinone‐embedded imidazo[1,2‐a]benzimidazoles. Insight into a plausible mechanism is discussed and supported by X‐ray crystal structure analysis.
Synthesis of Fluorinated exo‐Glycals through Modified Julia Olefination
Authors: Habib Samuel , Larnaud Florent , Pfund Emmanuel , Lequeux Thierry , Fenet Bernard , Goekjian Peter G. , Gueyrard David 
Published: February 2013

AbstractAn efficient synthesis of fluorinated enol ethers derived from carbohydrates is reported. A modified Julia olefination reaction of functionalized lactones with fluorine‐substituted sulfones gives the corresponding monofluorinated tri‐ or tetrasubstituted exo‐glycals.
The influence of topography and approach angles on local deflections of airflow within a coastal blowout
Authors: Pease Patrick , Gares Paul 
Published: February 2013

ABSTRACTThe spatial variability of air flow through complex topography is an important, but not fully understood, component of dune development and dynamics. This study examines the spatial variability of the wind field in a linear blowout in coastal dunes at Jockey's Ridge State Park, on the Outer Banks of North Carolina. A spatial array of single‐height anemometers and wind vanes were placed within the blowout. Topography exerted a significant steering effect when onshore winds approached from directions within 50° of the blowout axis. Under those conditions wind flow in the blowout aligned to the axis regardless of approach angle, maximizing the potential for erosion and transport in the trough. In other locations aspect variations caused deflection both proportional and disproportional to changes in the approaching wind. When prevailing winds approached from directions more oblique than 50° to the blowout axis, topographic steering through the blowout trough was reduced and secondary flow generated by flow separation over the trough became more prominent. During those approach angles, wind directions and speeds within the upper blowout trough became erratic as vortices and turbulence dominated the flow, minimizing transport potential. The changing characteristics of airflow in the blowout relative to differing approach angles has implications on dune development and variations in transport potential under changing conditions. Copyright © 2013 John Wiley & Sons, Ltd.
Erosion, deposition, and the persistence of soil organic matter: mechanistic considerations and problems with terminology
Authors: Berhe Asmeret Asefaw , Kleber Markus 
Published: February 2013

ABSTRACTThe effect of erosional detachment, transport, and deposition of topsoil on the stock of soil organic matter (SOM) and its association with soil minerals has been a focus of a growing number of studies. A particularly lively debate is currently centered on the questions of whether terrestrial sedimentation of previously eroded SOM may constitute a relevant sink for atmospheric carbon dioxide (CO2), and how ‘stable’ such carbon (C) might be on multidecadal timescales. In this commentary, we illustrate how redistribution of eroded SOM within a landscape can create situations that are not adequately described by the jargon commonly used to characterize C turnover dynamics. We argue that more quantitative and scientifically rigorous categories are needed to describe soil C turnover and to promote the development of innovative, numerical models of C dynamics in landscapes characterized by significant mass movement. Copyright © 2013 John Wiley & Sons, Ltd.
Formation of thick stratiform Fe‐Ti oxide layers in layered intrusion and frequent replenishment of fractionated mafic magma: Evidence from the Panzhihua intrusion, SW China
Authors: Song Xie‐Yan , Qi Hua‐Wen , Hu Rui‐Zhong , Chen Lie‐Meng , Yu Song‐Yue , Zhang Jia‐Fei 
Published: February 2013

AbstractThe Panzhihua intrusion is one of the largest layered intrusions that hosts huge stratiform Fe‐Ti oxide layers in the central part of the Emeishan large igneous province, SW China. Up to 60 m thick stratiform massive Fe‐Ti oxide layers containing ~85 modal% of magnetite and ilmenite and overlying magnetite gabbro compose cyclic units of the Lower Zone of the intrusion. The cyclic units of the Middle Zone consist of magnetite gabbro and overlying gabbro. In these cyclic units, contents of Fe2O3(t), TiO2 and Cr and Fe3+/Ti4+ ratio of the rocks decrease upward, Cr content of magnetite and forsterite percentage of olivine decrease as well. The Upper Zone consists of apatite gabbro characterized by enrichment of incompatible elements (e.g., 12–18 ppm La, 20–28 ppm Y) and increasing of Fe3+/Ti4+ ratio (from 1.3 to 2.3) upward. These features indicate that the Panzhihua intrusion was repeatedly recharged by more primitive magma and evolved magmas had been extracted. Calculations using MELTS indicate that extensive fractionation of olivine and clinopyroxene in deep level resulted in increasing Fe and Ti contents in the magma. When these Fe‐Ti‐enriched magmas were emplaced along the base of the Panzhihua intrusion, Fe‐Ti oxides became an early crystallization phase, leading to a residual magma of lower density. We propose that the unusually thick stratiform Fe‐Ti oxide layers resulted from coupling of gravity settling and sorting of the crystallized Fe‐Ti oxides from Fe‐Ti‐enriched magmas and frequent magma replenishment along the floor of the magma chamber.
Crustal structure across the Costa Rican Volcanic Arc
Authors: Hayes Jorden L. , Holbrook W. Steven , Lizarralde Dan , van Avendonk Harm J. A. , Bullock Andrew D. , Mora Mauricio , Harder Steven , Alvarado Guillermo E. , Ramírez Carlos 
Published: February 2013

AbstractIsland arcs are proposed to be essential building blocks for the crustal growth of continents; however, island arcs and continents are fundamentally different in bulk composition: mafic and felsic, respectively. The substrate upon which arcs are built (oceanic crust versus large igneous province) may have a strong influence on crustal genesis. We present results from an across‐arc wide‐angle seismic survey of the Costa Rican volcanic front which test the hypothesis that juvenile continental crust is actively forming at this location. Travel‐time tomography constrains velocities in the upper arc to a depth of ~15 km where average velocities are <6.5 km/s. The upper 5 km of crust is constrained by velocities between 4.0 and 5.5 km/s, which likely represent sediments, volcaniclastics, flows, and small intrusions. Between 5 and 15 km depth, velocities increase slowly from 5.5 to 6.5 km/s. Crustal thickness and lower crustal velocities are roughly constrained by reflections from an inferred crust‐mantle transition zone. Crustal thickness beneath the volcanic front in Costa Rica is ~40 km with best‐fit average lower‐crustal velocities between 6.8 and 7.1 km/s. Overall, velocities across the arc in central Costa Rica are at the high‐velocity extreme of bulk continental crust velocities and are lower than modern island arc velocities, suggesting that continental compositions are created at this location. These data suggest that preexisting thick crust of the Caribbean Large Igneous Province has a measurable effect on bulk composition. This thickened arc crust may be a density filter for mafic material and thereby support differentiation toward continental compositions.
Magnetite deformation mechanism maps for better prediction of strain partitioning
Authors: Till J. L. , Moskowitz Bruce 
Published: February 2013

AbstractA meta‐analysis of existing experimental deformation data for magnetite and other spinel‐structured ferrites reveals that previously published flow laws are inadequate to describe the general deformation behavior of magnetite. Using updated rate equations for oxygen diffusion in magnetite, we present new flow laws that closely predict creep rates similar to those found in deformation experiments and that can be used to predict strain partitioning between cubic Fe oxides and other phases in the Earth's crust. New deformation mechanism maps for magnetite have been constructed as functions of temperature and grain size. Using the revised creep parameters, estimates of strain partitioning between magnetite, ilmenite, and plagioclase indicate that concentrated zones of Fe‐Ti oxides in oceanic crust near slow‐spreading ridges could accommodate significant amounts of strain at moderate temperatures and may contribute to aseismic creep along spreading‐segment faults.
New Lignans from the Aerial Parts of Rudbeckia laciniata
Authors: Lee Seung Young , Woo Kyeong Wan , Kim Chung Sub , Lee Dong Ung , Lee Kang Ro 
Published: February 2013

AbstractThree new furofuran lignans, (+)‐4,4′‐O‐diangeloylpinoresinol (1), (+)‐4,4′‐O‐diangeloylmedioresinol (2), and (+)‐4,4′‐O‐diangeloylsyringaresinol (3), together with the known compound (+)‐syringaresinol, were isolated from the MeOH extract of Rudbeckia laciniata. The structure elucidation of these compounds were based on 1D‐ and 2D‐NMR, and HR‐ESI‐MS data. The additional structural evidence was obtained from alkaline hydrolysis of the compounds.
Synthesis and Metal Complexes of Thiourea Ligands Containing Carbohydrate‐Derived Substituents
Authors: Sternberg Michelle , Rust Jörg , Lehmann Christian W. , Mohr Fabian 
Published: February 2013

AbstractTwo glucose‐derived thiourea derivatives,2aand2b, were prepared by addition of the corresponding amino sugars to a solution of 4‐nitrobenzoyl isothiocyanate (Scheme 1). The thioureas were isolated as colorless solids in good yields and were fully characterized by NMR spectroscopy, optical rotation, elemental analysis, and also by single‐crystal X‐ray diffraction. Attempts to obtain CuIIand NiIIbis(chelate) complexes with these thioureas failed. However, the C(1)‐protected thiourea derivative2areacted with orthopalladated acetato‐bridged dimers to afford the corresponding monomeric PdIIcomplexes3and4(Scheme 2). In these compounds, the thiourea coordinates to the metal as monoanionic O,S chelate ligand, which was confirmed by X‐ray crystallography.
Further Explorations into the Synthesis of Dehydro‐Hedione®
Authors: Winter Béat , Chapuis Christian , Brauchli Robert , de Saint Laumer Jean‐Yves 
Published: February 2013

AbstractDehydrohedione (DHH) 1 may be obtained in 20% overall yield by a Reformatsky reaction with enone methyl ether 3b, followed by acidic workup of the crude reaction mixture. Alternatively, epoxidation (3‐chloroperbenzoic acid, CH2Cl2, 84% yield) of the tertiary allyl alcohol derivative 4 affords a 1 : 2 mixture of 8a and 8b. The latter epoxy ester 8b may also be obtained stereoselectively either from 4 (tBuO2H, [Mo(CO)6], 1,2‐dichloroethane, 70°, 62% yield; or tBuO2H, [VO(acac)2], decane, 20°, 92% yield), or from 5 (AcOMe, LiN(SiMe3)2, THF, −78°, 84–87%). BF3⋅Et2O‐Catalyzed cascade rearrangement and OH elimination of 8a afford selectively DHH 1 in 88% yield. The cis disposition of the side chains of the weakly odoriferous hedione‐like analogues 2b and 2c was maintained by means of either an epoxy or a cyclopropane moiety.