bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Efficient Synthesis of Functionalized Unsymmetrical Dialkyl Trisulfanes.
Authors: Lach Slawomir , Witt Dariusz 
Published: January 2014

AbstractThe reaction of the substrates (I) with alkyl disulfanyl anions generated in situ from S‐acetyl disulfanyl precursors affords the title species in good to excellent yields.
ChemInform Abstract: [6π + 2π]‐Cycloaddition of α,ω‐Diallenes and α,ω‐Diacetylenes to 1,3,5‐Cycloheptatriene in the Presence of TiCl4—Et2AlCl
Authors: D'yakonov V. A. , Kadikova G. N. , Khalilov L. M. , Dzhemilev U. M. 
Published: January 2014

Abstractas an efficient preparative method for the synthesis of bis(endo‐bicyclononapolyenes) (III) and (V), resp., linked by polymethylene spacers
ChemInform Abstract: Diversity‐Oriented Approach to Novel Spirocyclics via Enyne Metathesis, Diels—Alder Reaction, and a [2 + 2 + 2] Cycloaddition as Key Steps
Authors: Kotha Sambasivarao , Ali Rashid , Tiwari Arti 
Published: January 2014

AbstractSynthetic approaches to diene (VI) and the masked diene (XXI) are described involving enyne metathesis and [2 + 2 + 2] cycloaddition reactions as key steps.
ChemInform Abstract: Studies on ZnBr2‐Mediated Synthesis of Axially Chiral Aryl‐Substituted Allenes from Terminal Alkynes, Aromatic Aldehydes and (S)‐α,α‐Diphenylprolinol.
Authors: Ye Juntao , Lue Ruizhi , Fan Wu , Ma Shengming 
Published: January 2014

AbstractCondensation of terminal alkynes and aldehydes, promoted by ZnBr2 and equimolar amounts of (S)‐diphenylprolinol, gives axially chiral 1,3‐disubstituted allenes with excellent enantioselectivity.
ChemInform Abstract: Iron(II) Complexes are Suitable Catalysts for the Isomerization of Trifluoromethylated Allylic Alcohols. Synthesis of Trifluoromethylated Dihydrochalcones.
Authors: Cahard Dominique , Bizet Vincent , Dai Xiaoyang , Gaillard Sylvain , Renaud Jean‐Luc 
Published: January 2014

Abstract5 Iron(II) complexes are tested as catalysts for the isomerization of trifluoromethylated allylic alcohols.
ChemInform Abstract: Copper‐Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols.
Authors: Chen Zhi‐Min , Bai Wei , Wang Shao‐Hua , Yang Bin‐Miao , Tu Yong‐Qiang , Zhang Fu‐Min 
Published: January 2014

AbstractThe title reaction is valuable for the difunctionalization of alkenes through simultaneous construction of a C—CF3 bond and a quaternary carbon center, and could provide a straightforward strategy for the preparation of α‐quaternary β‐trifluoromethyl ketone derivatives.
ChemInform Abstract: Acid‐Catalyzed Reactions of 3‐Hydroxy‐2‐oxindoles with Electron‐rich Substrates: Synthesis of 2‐Oxindoles with All‐Carbon Quaternary Center.
Authors: Kinthada Lakshmana K. , Ghosh Santanu , De Subhadip , Bhunia Subhajit , Dey Dhananjay , Bisai Alakesh 
Published: January 2014

AbstractLewis‐acid catalyzed C—C bond forming reactions of in situ generated 2H‐indol‐2‐ones (I) with various 2π and other electrophiles, such as allylsilane, phenylacetylene, acetophenone, styrenes and indole are reported.
ChemInform Abstract: Calix[6]arene Sulfonic Acids Catalyzed Michael Reactions of Indoles with α,β‐Unsaturated Ketones in Water Assisted by Microwave Radiation.
Authors: Xie Yuanyuan , Mao Linfeng , Li Lehuan 
Published: January 2014

AbstractSurfactant‐type calix[6]arene sulfonic acids bearing pendant aliphatic chains efficiently catalyzed the title Michael reaction under environmentally friendly conditions.
ChemInform Abstract: Asymmetric Organocatalytic Synthesis of Spiro‐cyclopropaneoxindoles.
Authors: Noole Artur , Malkov Andrei V. , Kanger Toenis 
Published: January 2014

AbstractA wide range of spiro‐cyclopropaneoxindoles is prepared via organocatalytic cyclopropanation of alkylidene oxindoles or α,β‐unsaturated aldehydes.
ChemInform Abstract: An Efficient and Green Synthesis of 6‐Amino‐3‐phenyl‐4‐aryl‐1,4‐dihydropyrano[2,3‐c]pyrazole‐5‐carbonitrile Derivatives under Ultrasound Irradiation in Aqueous Medium
Authors: Zou Yi. , Hu Yu , Liu Hai , Shi Da‐Qing 
Published: January 2014

Abstractvia a four‐component reaction
ChemInform Abstract: Synthesis of Chromene‐2‐thiones and in vitro Evaluation of Their Antifungal and Antibacterial Activities.
Authors: Devi Nepram Sushuma , Singh Thokchom Prasanta , Khumanthem Nonibala , Singh Okram Mukherjee 
Published: January 2014

AbstractA variety of chromene‐2‐thiones (III) (15 examples) are synthesized via CuCl2‐catalyzed condensation of salicylaldehydes (I) with β‐oxodithioesters.
ChemInform Abstract: Synthesis and Antimicrobial Screening of Some Novel Chromones and Pyrazoles with Incorporated Isoxazole Moieties.
Authors: Badadhe P. V. , Patil L. R. , Bhagat S. S. , Chate A. V. , Shinde D. W. , Nikam M. D. , Gill C. H. 
Published: January 2014

AbstractThe title compounds (III), (IV) are screened for their antimicrobial activity.
ChemInform Abstract: A Facile One Pot Synthesis of New Tricyclic Coumarins from Single Synthon.
Authors: Kalkhambkar Rajesh G. , Kulkarni Geeta M. , Kulkarni Manohar V. 
Published: January 2014

AbstractA simple and high‐yielding protocol for the synthesis of a library of tricyclic coumarins is developed using 8‐formyl‐7‐hydroxy‐4‐methylcoumarin (I) as a single synthon.
ChemInform Abstract: Chiral Bifunctional Squaramide Catalyzed Asymmetric Tandem Michael‐Cyclization Reaction: Efficient Synthesis of Optically Active 2‐Amino‐4H‐chromene‐3‐carbonitrile Derivatives.
Authors: Hu Keling , Lu Aidang , Wang Youming , Zhou Zhenghong , Tang Chuchi 
Published: January 2014

AbstractAn enantioselective cascade Michael addition/cyclization of ortho‐hydroxy‐nitrostyrenes (I) with malononitrile is developed using a chiral bifunctional squaramide derivative as catalyst.
ChemInform Abstract: 2‐(Quinolin‐4‐ylthio)‐1,3,4‐oxadiazole Derivatives: Design, Synthesis, Antibacterial and Antifungal Studies.
Authors: Modh Rahul P. , Shah Dhruvin , Chikhalia Kishor H. 
Published: January 2014

AbstractThe product (IIIa), (IIIb), (IIId), and (IIIf) show moderate activity against bacteria (E.
ChemInform Abstract: Chitosan‐SO3H: An Efficient, Biodegradable, and Recyclable Solid Acid for the Synthesis of Quinoline Derivatives via Friedlaender Annulation.
Authors: Reddy B. V. Subba , Venkateswarlu A. , Reddy G. Niranjan , Reddy Y. V. Rami 
Published: January 2014

AbstractHighly acidic chitosan sulfate is found to catalyze the Friedlaender synthesis.
ChemInform Abstract: Regioselective Synthesis and Antibacterial Evaluation of a New Class of Substituted Pyrazolo[3,4‐b]pyridines.
Authors: Mamaghani Manouchehr , Tabatabaeian Khalil , Bayat Mitra , Nia Roghayeh Hossein , Rassa Mehdi 
Published: January 2014

AbstractA simple and efficient approach for the synthesis of novel, highly functionalized indole substituted pyrazolo[3,4‐b]pyridines (IV) is developed using a regioselective one‐pot three‐component reaction.
ChemInform Abstract: Chemoselectivity in the Reaction of 2‐Diazo‐3‐oxo‐3‐phenylpropanal with Aldehydes and Ketones.
Authors: Zhang Jiantao , Xu Jiaxi 
Published: January 2014

AbstractTitle compound (I) reacts with cyclic ketones (II) and aromatic aldehydes with weak electron‐donating substituents (IV) to generate 1,3‐dioxin‐4‐one derivatives (III) and (V), respectively.
ChemInform Abstract: Mild and Efficient Synthesis of 2,8‐Di(3‐aryl[1,8]naphthyridin‐2‐yl) 1,2,3,4,6,7,8,9‐Octahydropyridazino[4,5‐g]phthalazine‐1,4,6,9‐tetraones Using Non‐Traditional Conditions and Evaluation of Their Antibacterial Activity.
Authors: Mogilaiah K. , Chandra A. Vinay , Srivani N. , Rao A. Nageswara 
Published: January 2014

AbstractThe synthesis of the title compounds (III) by grinding results in similar yields.
ChemInform Abstract: Silica Gel Supported Bismuth Nitrate Pentahydrate: A Highly Active Catalyst Under Solvent Free Conditions Towards the Synthesis of Dihydropyrimidin‐2(1H)‐ones and Their Sulfur Analogues
Authors: Hingane Dattatray G. , Shumaila Abdullah M. A. , Kusurkar Radhika S. 
Published: January 2014

Abstractvia Biginelli‐type reactions
ChemInform Abstract: Amino Acid Salts Catalyzed Asymmetric Aldol Reaction of Tryptanthrin: A Straightforward Synthesis of Phaitanthrin A (V) and Its Derivatives.
Authors: Kang Guowei , Luo Zhenli , Liu Chongxing , Gao Hang , Wu Quanquan , Wu Huayue , Jiang Jun 
Published: January 2014

AbstractThe first asymmetric synthesis of the title compound (V) is achieved on a gram‐scale.
ChemInform Abstract: Pyrrolo[2,3‐d]pyrimidine Synthesis Through Activation of N‐Benzyl Groups by Distal Amides.
Authors: El Kaim Laurent , Grimaud Laurence , Wagschal Simon 
Published: January 2014

AbstractA new activation mode of CH2‐benzylamino groups is observed during the preparation of pyrrolopyrimidines from Ugi—Smiles adducts (VII).
ChemInform Abstract: Tandem Hydroformylation/Reductive Amination of 3‐Allyl‐2‐methylquinazolin‐4(3H)‐one.
Authors: El‐Badry Yaser A. , El‐Farargy Ahmed F. , Eilbracht Peter 
Published: January 2014

AbstractThe catalytic carbonylation of title compound (I) under different conditions affords a mixture of linear and branched hydroformylation products (III) and (IV).
ChemInform Abstract: A Two‐Step Synthesis of Selected 1,2,3,4‐Tetrahydroquinoxaline Derivatives from N‐Aryl‐2‐nitrosoanilines and Arylidenecyanoacetic Esters.
Authors: Krolikiewicz Magdalena , Blaziak Kacper , Danikiewicz Witold , Wrobel Zbigniew 
Published: January 2014

AbstractSequential nucleophilic addition of nitroaniline to alkyl arylidenecyanoacetates and intramolecular cyclization provides tetrahydroquinoxaline derivatives with excellent regio‐ and diastereoselectivity.
ChemInform Abstract: Regioselective Glycosylation of Unprotected Phenyl 1‐Thioglycopyranosides with Phenylboronic Acid as a Transient Masking Group.
Authors: Fenger Thomas Hauch , Madsen Robert 
Published: January 2014

AbstractThe presented method for the title reaction can be also used for two consecutive glycosylations in one‐pot manner.
ChemInform Abstract: Two Novel Plumeran Indole Alkaloids Isolated from Aspidosperma cylindrocarpon (Apocynaceae)
Authors: Guimaraes Heloisa A. , Vieira Ivo J. C. , Braz‐Filho Raimundo , Crotti Antonio E. M. , dos S. Almeida Vitor , de Paula Renata C. 
Published: January 2014

Abstractisolation, structure determination and antimalarial activity
ChemInform Abstract: Total Synthesis of Attenols A and B.
Authors: Reddy B. V. Subba , Reddy B. Phaneendra , Swapnil N. , Yadav J. S. 
Published: January 2014

AbstractA concise approach for the total synthesis of attenols A (I) and B (II) is described involving MacMillan α‐aminooxylation, Evans′ asymmetric alkylation, Brown allylation, and spiro‐ketalization as key steps.
ChemInform Abstract: Area Selective Growth of Titanium Diselenide Thin Films into Micropatterned Substrates by Low‐Pressure Chemical Vapor Deposition.
Authors: Reid Gillian , et al. et al. 
Published: January 2014

AbstractThe neutral, distorted octahedral complex [TiCl4(SeBu2)2] is prepared by reaction of TiCl4 with SeBu2 (1:2 ratio) in anhydrous CH2Cl2 and used for low‐pressure CVD of TiSe2 films on SiO2 and TiN substrates.
Bis‐arylidene Oxindoles as Anti‐Breast‐Cancer Agents Acting via the Estrogen Receptor
Authors: Pal Abhishek , Ganguly Anirban , Ghosh Avijit , Yousuf Md , Rathore Bhowmira , Banerjee Rajkumar , Adhikari Susanta 
Published: January 2014

AbstractWe report a new family of bis‐arylidene oxindole derivatives that show highly selective estrogen receptor (ER)‐mediated anticancer activity at low‐nanomolar concentrations in ER‐positive (ER+) breast cancer cells. In terms of cell growth inhibition, IC50 values for these compounds in ER+ breast cancer cells are two to three orders of magnitude lower than in ER‐negative (ER−) breast cancer cells and non‐cancer cells. In comparison with known bis‐arylidene drugs, these compounds are at least three orders of magnitude more toxic than tamoxifen and 1.5–4‐fold more toxic than 4‐hydroxytamoxifen in ER+ MCF‐7 cancer cells. These oxindoles inhibit ER transactivation, and their anticancer activities are inhibited in ER‐depleted MCF‐7 cells. Some of these nonsteroidal molecules also exhibit essential properties of selective ER down‐regulation. From the development of two series of bis‐arylidene oxindole‐based compounds, we report a new series of anticancer agents for estrogen‐responsive breast cancer.
Challenging combination of CO2 geological storage and coal mining in the Ordos basin, China
Authors: Li Qi , Fei Wenbin , Liu Xuehao , Wei Xiaochen , Jing Miao , Li Xiaochun 
Published: January 2014

AbstractIn a CO2 storage project, CO2 may be able to escape from channels caused by the formation's uplift, fault reactivation, and wellbore failure owing to overpressure build‐up and likewise, coal excavation during which equilibrium disruption of stress could possibly lead to floor heave, roof collapse, and surface subsidence. When the carbon capture and storage (CCS) project and coal mining engineering activity occur in the same location, coal mining may also induce wellbore failure if the stope border is too close to the well. This is a real and challenging problem for CO2 geological storage in the Ordos Basin in China. We consequently investigated four key problems for such a combination system. The main conclusions obtained from numerical simulations are as follows. (i) Permeability is the most important factor that affects the flow rate at the injection point and the reservoir pore pressure. (ii) The interfaces between the coal layers and their adjacent rocks are easy to damage the casing. Our work suggests that the coal pillar should be set aside at least 90 m to maintain the tensile strength of the casing below the designed value. (iii) No impact occurs to the caprock from coal mining; thus, a coal seam 440 m in depth could be excavated if the original caprock is intact and no complex geological structure exists in the location. (iv) Permeability is the most crucial factor affecting surface displacement, and CO2 injection permits a surface displacement reduction of 0.04136 m compared with individual coal excavation.
Expression and functional characterisation of a soluble form of Tomato yellow leaf curl virus coat protein
Authors: Wang Lan‐Lan , Wei Xue‐Mei , Ye Xiao‐Dong , Xu Hong‐Xing , Zhou Xue‐Ping , Liu Shu‐Sheng , Wang Xiao‐Wei 
Published: January 2014

AbstractBACKGROUNDTomato yellow leaf curl virus (TYLCV), a member of the genus Begomovirus within the family Geminiviridae, is an important pathogen of tomato in many tropical, subtropical and temperate regions. TYLCV is exclusively transmitted by the whitefly Bemisia tabaci in a circulative manner. The viral coat protein (CP) has been assumed to play important roles in the entry of TYLCV into the insect midgut cells.RESULTSTesting the hypothesis that CP plays an important role in TYLCV acquisition by B. tabaci, a soluble form of the CP was expressed and purified. The purified recombinant CP made it possible to examine the function of TYLCV CP without other viral proteins. In an in vivo binding assay, specific binding of TYLCV CP to B. tabaci midguts was detected when purified CP was fed to B. tabaci. In addition, real‐time polymerase chain reaction analysis of virus titre revealed that B. tabaci fed with purified CP had reduced the level of virus in their midgut compared with those fed with bovine serum albumin or maltose‐binding protein. These results suggest that binding of TYLCV CP to the B. tabaci midgut specifically inhibits virus acquisition.CONCLUSIONSThe findings that TYLCV CP binds to B. tabaci midguts and decreases virus acquisition provide direct evidence that CP mediates the attachment of TYLCV to receptors on the epithelial cells of the B. tabaci midgut. © 2014 Society of Chemical Industry
Detoxification enzymes of Bemisia tabaci B and Q: biochemical characteristics and gene expression profiles
Authors: Guo Litao , Xie Wen , Wang Shaoli , Wu Qingjun , Li Rumei , Yang Nina , Yang Xin , Pan Huipeng , Zhang Youjun 
Published: January 2014

AbstractBACKGROUNDThe sweetpotato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), is one of the most invasive and destructive pests of field crops worldwide. The sibling species B and Q are the two most damaging members of the B. tabaci species complex. That Q is more resistant than B to many insecticides has been well documented. Over the last decade, Q has gradually displaced B and has become the dominant form of B. tabaci in field agricultural systems in most parts of China. To help understand the differences in insecticide resistance, the activities and gene expression profiles of detoxification enzymes in B. tabaci B and Q were investigated.RESULTSThe activity of P450 towards 7‐ethoxycoumarin was significantly higher (1.46‐fold higher) in Q than in B. The expression of 43 of 65 P450 genes was higher (>1‐fold) in Q than in B, and expression for eight P450 genes was more than 50‐fold greater in Q than in B. The increased expression of selected P450 genes in Q relative to B was confirmed with two other B strains and two other Q strains. On the other hand, carboxylesterase (CarE) activity was significantly lower (0.71‐fold lower) in Q than in B; the Km value of CarE was significantly lower in B than in Q, but the opposite was true for the Vmax value of CarE. Glutathione S‐transferase activity and values of Km and Vmax did not differ between B and Q.CONCLUSIONEnhanced metabolic detoxification of insecticides by P450s may be an important reason why B. tabaci Q is more resistant than B. tabaci B to insecticides. © 2014 Society of Chemical Industry
Changes in fetal Doppler indices as a marker of failure to reach growth potential at term
Authors: Morales‐Roselló J. , Khalil A. , Morlando M. , Papageorghiou A. , Bhide A. , Thilaganathan B. 
Published: January 2014

ABSTRACTObjectiveTo evaluate whether changes in the middle cerebral artery (MCA), umbilical artery (UA) and cerebroplacental ratio (CPR) Doppler indices at term might be used to identify those appropriate‐for‐gestational‐age (AGA) fetuses that are failing to reach their growth potential (FRGP).MethodsThis was a retrospective cohort study of data obtained in a single tertiary referral center over a 10‐year period from 2002 to 2012. The UA pulsatility index (PI), MCA‐PI and CPR were recorded between 37+0 and 41+6 weeks within 14 days before delivery. The Doppler parameters were converted into multiples of the median (MoM), adjusting for gestational age, and their correlation with birth‐weight (BW) centiles was evaluated by means of regression analysis. Doppler indices were also grouped according to BW quartiles and compared using Kruskal–Wallis and Dunn's post‐hoc tests.ResultsThe study included 11 576 term fetuses, with 8645 (74.7%) classified as AGA. Within the AGA group, fetuses with lower BW had significantly higher UA‐PI, lower MCA‐PI and lower CPR MoM values. Large‐for‐gestational‐age (LGA) fetuses were considered as the group least likely to be growth‐restricted. The CPR MoM < 5th centile (0.6765 MoM) in these fetuses was used as a threshold for diagnosing FRGP. Using this definition, in the AGA pregnancies the percentage of fetuses with FRGP was 1% in the 75–90th BW centile group, 1.7% in the 50–75th centile group, 2.9% in the 25–50th centile group and 6.7% in the 10–25th centile group.ConclusionAGA pregnancies may present with fetal cerebral and placental blood flow redistribution indicative of fetal hypoxemia. Fetal Doppler assessment may be of value in detecting AGA pregnancies that are subject to placental insufficiency, fetal hypoxemia and FRGP. Future studies are needed to evaluate the appropriate threshold for the diagnosis of FRGP and the diagnostic performance of this new approach for the management of growth disorders. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd
The Protective Effect of Parity in Hormone Receptor‐Positive, Ki‐67 Expressing Breast Cancer
Authors: Lee Se Kyung , Kim Seok Won , Han Sang‐Ah , Kil Won Ho , Lee Jeong Eon , Nam Seok Jin 
Published: January 2014

AbstractBackground
Epidemiologic studies showed that the experience of pregnancy is associated with a reduced risk of breast cancer. We hypothesized that parity may differentially be associated with the development of invasive breast cancer by each subtype.MethodsWe reviewed the clinical, radiological, and pathological records of women diagnosed with invasive ductal carcinoma of the breast at Samsung Medical Center between 2005 and 2009. Clinicopathologic results were assessed by χ2 and Fisher’s exact tests with a Bonferroni correction for categorical variables, and by the Kruskal–Wallis test for nonparametric continuous variables. A multinomial logistic regression model was used for multivariate analysis.ResultsAmong a total of 3,095 patients, 283 (9.14 %) patients were nulliparous. Older age, higher pN, and expression of HER2 were associated with parity. In the analysis between parity and molecular subtypes, parity also had a variable influence on breast cancer subtypes (p = 0.032). Intergroup analysis with multiple comparison showed that luminal B subtype was related to nulliparity compared with HER2‐positive subtypes (p = 0.03).ConclusionsThe effect of parity on the development of breast cancer differed by hormone receptor and HER2 expression. It seems that parity might have a protective effect against hormone receptor‐positive breast cancer, especially cancers expressing HR+ and Ki‐67. Further basic research to define and understand this result is ongoing.
Elaidic Acid Increases Hepatic Lipogenesis by Mediating Sterol Regulatory Element Binding Protein‐1c Activity in HuH‐7 Cells
Authors: Shao Fei , Ford David A. 
Published: January 2014

AbstractThe liver is the major organ responsible for lipid biosynthesis. Sterol regulatory element‐binding proteins (SREBP) are major transcription factors that regulate the expression of genes regulating fatty acid and cholesterol biosynthesis. Here we show that elaidic acid upregulates hepatic de‐novo fatty acid and cholesterol synthesis in HuH‐7 cells. To define the molecular mechanism involved in this unique regulation on hepatic lipogenesis, luciferase reporter gene assays were performed in HEK293 cells to compare the regulation of sterol regulatory element (SRE) that is present in SREBP‐target promoter by elaidic acid and oleic acid. The results show that elaidic acid potently induced SRE‐luciferase activity, whereas oleic acid inhibited this activity. Furthermore, elaidic acid increased SREBP‐1c mRNA, while oleic acid did not alter it. Oleic acid inhibited mature form of SREBP‐1 protein level, while elaidic acid did not show inhibitory effects. In addition, elaidic acid was also found to increase several selected lipogenic genes that are involved in fatty acids and sterol synthesis. These data demonstrate a unique role of elaidic acid, the most abundant trans fatty acid, in modulating hepatic lipogenesis.