bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asparagine couples group AStreptococcalmetabolism to virulence
Authors: Sharma Abhinay , Anand Aparna , Ravins Miriam , Horstmann Nicola , McIver Kevin S. , Hanski Emanuel 
Published: July 2024

AbstractStreptococcus(GAS) is a highly adapted and human-restricted pathogen causing a wide variety of infections, some life-threatening1. This ability is linked to the expression of many virulence factors, whose transcription is regulated by the two-component system, CovR/S2–5.Here, we show that genome transcription of GAS cultured in a chemically defined medium (CDM) is globally affected when supplemented with asparagine (Asn), including increased expression of many virulence genes. For the first time, we report that GAS solely depends on asparagine synthetase (AsnA) for Asn synthesis, on the ABC transporter (GlnPQ) to import Asn, and on the asparaginase (AsnB) to maintain a precisely balanced intracellular Asn concentration. Furthermore, we show that mutants defective in eitherasnA,glnP, orasnB express significantly lower levels of virulence factors in CDM and are severely attenuated in the sublethal murine model of human GAS soft-tissue infection.We further show that the synthesis and import of Asn in GAS are ATP-dependent and negatively regulated by intracellular Asn. Thus, Asn availability controls the intracellular ATP level. When ATP becomes limiting, CovR phosphorylation decreases. This augments GAS growth rate, virulence production, metabolism, andvice versawhen the ATP level increases. Furthermore, excess Asn accumulates inside GAS in AsnB mutant, destroying the balance between Asn and ATP. We discuss the high similarity between these mechanistic principles of the Asn-mediated control of GAS virulence and metabolism to the Asn-mediated control of tumor growth6, indicating evolutionary significance.
FoldToken3: Fold Structures Worth 256 Words or Less
Authors: Gao Zhangyang , Tan Cheng , Li Stan Z. 
Published: July 2024

AbstractProtein structure tokenization has attracted increasing attention in both protein representation learning and generation. While recent work, like FoldToken2 and ESM3, has achieved good reconstruction performance, the compressoin ratio is still limited. In this work, we propose FoldToken3, a novel protein structure tokenization method that can compress protein structures into 256 tokens or less and ensure the reconstruction quality comparable to FoldToken2. To the best of our knowledge, FoldToken3 is the most efficient, light-weight, and compression-friendly protein structure tokenization method. And it will benifit a wide range of protein structure-related tasks, such as protein structure alignment, generation, and representation learning. The work is still in progress and the code will be available upon acceptance.
Zinc Supplementation in the management of acute diarrhea in high-income countries – A systematic review and meta-analysis
Authors: Revoredo Túlio , Alves Lucas Victor , Victor David Romeiro , Alves João Guilherme Bezerra 
Published: July 2024

AbstractThe World Health Organisation (WHO) and the United Nations Children’s Fund (UNICEF) recommend zinc supplementation for children with diarrhea.However, low- and middle-income countries (LMICs) conducted the majority of the studies supporting this recommendation. Although the mortality rate of acute diarrhoea in developed countries is low, diarrhoea leads to a high number of clinical care and hospital admissions, which represents a significant economic burden. This systematic review assessed the therapeutic benefits of zinc supplementation in the treatment of acute diarrhoea in children living in high-income countries. We conducted a literature search on the Medline, Embase, Cochrane, and Scielo databases to find published randomised controlled trials on zinc supplementation and acute diarrhoea in children residing in developed countries. We conducted a systematic literature search of the databases, uncovered 609 titles, and included 3 trials, totaling 620 treated children with acute diarrhoea, after reviewing abstracts and full manuscripts for inclusion and exclusion criteria. Two studies showed that zinc did not interfere with the duration of diarrhea. According to the Cochrane Risk of Bias RoB2, risk was considered low in two studies and some concerns in another. There was no statistically significant reduction in the mean RR for the occurrence of diarrheal episodes after 7 days of zinc supplement administration (0.4% vs. 0.6%; RR 0.73; 95% CI 0.28-1.92; p = 0.53; I2 = 16%). Zinc supplementation did not reduce the duration of acute diarrhoea among children living in developed countries.Whats is New-Zinc supplementation did not reduce the duration of acute diarrhea among children living in developed countries.-The anti-diarrheal effect of zinc is dependent on zinc deficiency.-The WHO and UNICEF recommended regimen of therapeutic zinc should not include high-income countries.Whats is Known-Zinc supplementation may reduce the duration and severity of diarrhea in poor countries-The World Health Organization (WHO) and the United Nations International Children’s Emergency Fund (UNICEF) recommend zinc supplementation for children with acute diarrhea
A method of identifying domain-specific academic user information needs based on academic Q&A communities
Authors: Qin Chunxiu , Wang Yulong , Ma XuBu , Liu Yaxi , Zhang Jin 
Published: July 2024

Purpose
To address the shortcomings of existing academic user information needs identification methods, such as low efficiency and high subjectivity, this study aims to propose an automated method of identifying online academic user information needs.

Design/methodology/approach
This study’s method consists of two main parts: the first is the automatic classification of academic user information needs based on the bidirectional encoder representations from transformers (BERT) model. The second is the key content extraction of academic user information needs based on the improved MDERank key phrase extraction (KPE) algorithm. Finally, the applicability and effectiveness of the method are verified by an example of identifying the information needs of academic users in the field of materials science.

Findings
Experimental results show that the BERT-based information needs classification model achieved the highest weighted average F1 score of 91.61%. The improved MDERank KPE algorithm achieves the highest F1 score of 61%. The empirical analysis results reveal that the information needs of the categories “methods,” “experimental phenomena” and “experimental materials” are relatively high in the materials science field.

Originality/value
This study provides a solution for automated identification of academic user information needs. It helps online academic resource platforms to better understand their users’ information needs, which in turn facilitates the platform’s academic resource organization and services.
Click-through rate prediction model based on graph networks and feature squeeze-and-excitation mechanism
Authors: Bi Zhongqin , Sun Susu , Zhang Weina , Shan Meijing 
Published: July 2024

Purpose
Predicting a user’s click-through rate on an advertisement or item often uses deep learning methods to mine hidden information in data features, which can provide users with more accurate personalized recommendations. However, existing works usually ignore the problem that the drift of user interests may lead to the generation of new features when they compute feature interactions. Based on this, this paper aims to design a model to address this issue.

Design/methodology/approach
First, the authors use graph neural networks to model users’ interest relationships, using the existing user features as the node features of the graph neural networks. Second, through the squeeze-and-excitation network mechanism, the user features and item features are subjected to squeeze operation and excitation operation, respectively, and the importance of the features is adaptively adjusted by learning the channel weights of the features. Finally, the feature space is divided into multiple subspaces to allocate features to different models, which can improve the performance of the model.

Findings
The authors conduct experiments on two real-world data sets, and the results show that the model can effectively improve the prediction accuracy of advertisement or item click events.

Originality/value
In the study, the authors propose graph network and feature squeeze-and-excitation model for click-through rate prediction, which is used to dynamically learn the importance of features. The results indicate the effectiveness of the model.
Exploring IFRS in Islamic finance: a bibliometric and coding analysis of emerging topics and perspectives
Authors: Calandra Davide , Lanzalonga Federico , Biancone Paolo Pietro 
Published: July 2024

Purpose
Emerging economies are increasingly benefiting from Islamic finance principles. The distinctive features of this unconventional form of finance are starting to be considered even in developed economies. Islamic finance operates under prohibitions on interest, gambling, speculation and complex derivatives according to the dogma in the Quran, Sunnah, Ijma and Qiyas. International financial reporting standards (IFRS) allow companies to attract global capital due to overcoming international borders. However, Islamic finance cannot apply all accounting standards. Therefore, this study aims to explore the implementation of international accounting standards in the Islamic finance context to present applications and future research fields.

Design/methodology/approach
Using a bibliometric and coding analysis, the study analyses 226 peer-reviewed journal papers extracted from the Scopus database. Using the bibliometrix package, the authors explored the literature’s intellectual, conceptual and social structures, categorising the findings into thematic clusters relevant to traditional and Islamic finance paradigms.

Findings
The results reveal new and interesting elements using the lens of the conceptual, intellectual and social structure. Additionally, the authors find out three main thematic clusters: (1) IFRS and Islamic finance: general principles; (2) IFRS and Zakat; (3) IFRS and Murabaha compatibility; (4) IFRS and Takaful; and (5) IFRS and auditing organisation for Islamic financial institution: governance strategies.

Originality/value
The contribution is original as the authors discover institutional theory perspectives and a diatribe between positivist and ontological approaches.
Adoption of fintech products through environmental regulations in Jordanian commercial banks
Authors: Bani Atta Anas Ahmad 
Published: July 2024

Purpose
This study aims to examine the adoption of fintech products in Jordanian commercial banks, focusing on the influence of environmental regulations. Specifically, the study investigates the impact of environmental pressures (competitors pressure, customer pressure) and top management support on the adoption of fintech products.

Design/methodology/approach
A questionnaire survey was conducted, and data from 550 respondents familiar with the bank’s operations, once you have responses, use structure equation modeling to understand the relationships between variables. Also, applied the regression model to predict outcomes for new respondents. Ensure ethical considerations, like informed consent, are addressed throughout the process.

Findings
The results reveal that competitors pressure and customer pressure have a significant positive influence on the adoption of fintech products, indicating that banks are more likely to adopt fintech solutions when faced with increasing competition and customer demands. Furthermore, top management support was found to be positively associated with the adoption of fintech products, emphasizing the importance of leadership in driving successful integration. Also, regulators and policymakers can foster FinTech adoption in the banking sector by creating supportive frameworks that balance innovation and risk. The findings highlight the need for Jordanian commercial banks to recognize and respond to environmental pressures to remain competitive and meet customer expectations. Additionally, regulations might encourage the development of financial products and services within the fintech sector. This study enriches fintech adoption literature in the context of Jordanian commercial banks.

Originality/value
This study contributes to the existing literature by shedding light on the factors influencing fintech adoption in Jordanian commercial banks and provides practical implications for banks, regulators and policymakers seeking to promote fintech adoption within the financial sector.
Impact of religiosity on Pakistani youth green purchase intensions and behavior: extending theory of planned behavior
Authors: Hassan Masoodul , Mahmood Zeeshan , Khakwani Infal 
Published: July 2024

Purpose
Although much research has examined sustainable consumption, one key factor that has been rediscovered is religion. This study aims to include religiosity as a background variable to extend the theory of planned behavior in measuring the Pakistani youth’s green purchase intentions (GPI) and green purchase behavior (GPB) of energy-efficient home appliances.

Design/methodology/approach
Built on a positivist research philosophy and a deductive approach of a quantitative design, a convenience sample of 317 participants was approached via online forms. Partial least squares structural equation modeling was used to analyze both the measurement model and the structural model.

Findings
The results suggest that religiosity impacts consumers’ beliefs to maintain control over green behavior and perceived behavioral control (PBC), followed by sustainable attitudes (SA), beliefs that significant others endorse green behavior subjective norms (SN) and GPI. Besides, PBC, SN and SA impact GPI. Furthermore, GPI and PBC impact GPB. Finally, PBC, SN and SA mediate the religiosity and GPI link. However, the moderation effect of PBC on the link of GPI with GPB was not supported.

Research limitations/implications
The model developed is specific to the Muslim population in Pakistan. Therefore, the model might only be able to be generalized to nations that have a similar culture to the Muslims in Pakistan or in other developing countries.

Originality/value
The current research advances the knowledge on the 2030 Agenda for sustainable development goal (SDGs) (Goal-12) by clarifying the mechanisms whereby religiosity impacts factors of sustainable consumption including SA, PBC and SN.
A 3D-printed, dynamic, patient-specific knee simulator
Authors: Conconi Michele , Sancisi Nicola , Backus Reid , Argenti Christian , Shih Albert J 
Published: July 2024

Purpose
3D-printed devices proved their efficacy across different clinical applications, helping personalize medical treatments. This paper aims to present the procedure for the design and production of patient-specific dynamic simulators of the human knee. The scope of these simulators is to improve surgical outcomes, investigate the motion and load response of the human knee and standardize in-vitro experiments for testing orthopedic devices through a personalized physical representation of the patient’s joint.

Design/methodology/approach
This paper tested the approach on three volunteers. For each, a patient-specific mathematical joint model was defined from an magnetic resonance imaging (MRI) of the knee. The model guided the CAD design of the simulators, which was then realized through stereolithography printing. Manufacturing accuracy was tested by quantifying the differences between 3D-printed and CAD geometry. To assess the simulator functionality, its motion was measured through a stereophotogrammetric system and compared with the natural tibio-femoral motion of the volunteers, measured as a sequence of static MRI.

Findings
The 3D-printing accuracy was very high, with average differences between ideal and printed parts below ± 0.1 mm. However, the assembly of different 3D-printed parts resulted in a higher average error of 0.97 mm and peak values of 2.33 mm. Despite that, the rotational and translational accuracy of the simulator was about 5° and 4 mm, respectively.

Originality/value
Although improvements in the production process are needed, the proposed simulators successfully replicated the individual articular behavior. The proposed approach is general and thus extendible to other articulations.
Pure and suggestive impulse buying in mobile shopping app: shopping pattern of young consumers
Authors: Gupta Priyanka , Prashar Sanjeev , Parsad Chandan 
Published: July 2024

Purpose
This study differentiates pure impulse buying behaviour from suggestive impulse buying behaviour in using mobile shopping applications (apps). This study aims to assess the moderating effects of instant discount and cashback promotional offers along with the mediating effects of impulse buying intention (IBI) and user satisfaction (US), using the app stimuli (performance expectancy, effort expectancy, layout, atmosphere, privacy and security).

Design/methodology/approach
The study was done in three stages: analysis of variance, followed by structural equation modelling (SEM) and paired t-tests.

Findings
The results showed that instant discounts and cashback offers are different from each other for the mediating variable IBI. The SEM results for pure impulse buying showed that, except for layout, the remaining variables have a positive relationship with IBI. For suggestive impulse buying, effort expectancy and layout were significantly related to both the mediating variables. Finally, pure and suggestive impulse buying behaviour showed significant differences.

Originality/value
Previous studies have looked into impulse buying in its generic sense and not through the “types” of impulse buying they were measuring. As impulse buying behaviour is a predominant theme for discussion today, marketing professionals and researchers must comprehend the impact of app stimuli in the context of select types of impulse buying behaviour.
Beyond predator richness: How diversified cropping can enhance pest regulation
Authors: Peñaflor Maria Fernanda G. V. 
Published: July 2024

AbstractResearch Highlight discussing: Heinen, J.; Dominguez, V.; Aguilera, G.; Malsher, G.; Vesterinen, E.; Roslin, T.; Bommarco, R.; Bartomeus, I. (2024). Diversified cropping strengthens herbivore regulation by providing seasonal resource continuity to predators. Journal of Applied Ecology, https://doi.org/10.1111/1365‐2664.14674. Crop monocultures consist of homogenous agroecosystems highly dependent on pesticides for pest regulation and mineral fertilisation for maintaining plant nutrition, representing the least resilient system. Agricultural diversification practices can increase heterogeneity in agroecosystems, resulting in greater richness of arthropod predators and enhanced ecological services. Among natural enemies of pests, generalist predators are important for pest regulation as they prey on diverse arthropod pests and be present throughout the season. However, since they consume other predators (intraguild predation) and soil fauna, it is uncertain whether enhanced richness of generalist predators translates into improved pest regulation. The study by Heinen et al. examined how diversified crop rotation and organic fertilisation influenced predator–prey interactions throughout the cropping cycle in cereal fields. The predators' diet preference shifted over the growing season, indicating that soil fauna is an important resource for recruitment and maintenance of predators early in the season. Although intraguild predation was considerably high, it decreased across the season in fields with the greatest level of diversification, where predation of pests remained stable. This study demonstrated how diversified cropping is important for providing resource continuity with alternative prey (soil fauna and predators) over crop‐growing season, enhancing predator richness and herbivore regulation.
Interleg coordination in free‐walking bug Erthesina fullo (Hemiptera: Pentatomidae)
Authors: Han Qingfei , Chen Yuyu , Shen Huan , Wang Wei , Liu Xuefei , Wen Shikun , Qi Qian , Dai Zhendong , Yu Zhiwei , Gorb Stanislav N. , Ji Aihong 
Published: July 2024

AbstractInsects can adapt their walking patterns to complex and varied environments and retain the ability to walk even after significant changes in their physical attributes, such as amputation. Although the interleg coordination of intact insects has been widely described in previous studies, the adaptive walking patterns in free‐walking insects with amputation of 1 or more legs are still unclear. The pentatomid bug Erthesina fullo exhibits a tripod gait, when walking freely on horizontal substrates, like many other insects. In this study, amputations were performed on this species to investigate changes in interleg coordination. The walking parameters were analyzed, such as the locations of touchdown and liftoff, cycle period, walking speed, and head displacement of intact and amputated insects. The results show that E. fullo displays adaptive interleg coordination in response to amputations. With 1 amputated leg, bugs changed to a 3‐unit gait, whereas with 2 amputated legs they employed a wave gait. These data are helpful in exploring the motion mode control in walking insects and provide the theoretical basis for the gait control strategy of robots, when leg failure occurs.
Efficacy of robot‐assisted thoracoscopic surgery for managing thymoma recurrence following sternotomy: a case report
Authors: Takamori Satoshi , Nakatsuka Marina , Endo Makoto 
Published: July 2024

AbstractThis report addresses the management strategy and effectiveness of robot‐assisted thoracoscopic surgery (RATS) for treating local recurrence of thymoma, a condition often complicated by severe adhesions and limited data on re‐operation following median sternotomy. We report about a 43‐year‐old man with thymoma recurrence 4 years after thymothymectomy via a median sternotomy. Follow‐up computed tomography revealed a nodule adjacent to the left brachiocephalic vein, indicating possible thymoma recurrence. Thus, re‐operation was performed using a left‐sided approach via RATS with an artificial pneumothorax. The manipulation space was secured with an artificial pneumothorax, and multidirectional manipulation using RATS demonstrated good efficacy. Collectively, this case highlights the efficacy of RATS as a viable approach for managing thymoma recurrence in mediastinal locations, particularly when sternotomy is complicated by severe adhesions.