bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unified Huntington's disease rating scale for advanced patients: Validation and follow‐up study
Authors: Youssov Katia , Dolbeau Guillaume , Maison Patrick , Boissé Marie‐Françoise , de Langavant Laurent Cleret , Roos Raymund A.C. , Bachoud‐Lévi Anne‐Catherine 
Published: October 2013

ABSTRACTThe Unified Huntington's Disease Rating Scale (UHDRS) adequately measures decline in patients at early and moderate stages of Huntington's disease (HD). In advanced patients, floor effects hamper the evaluation, thus calling for an adjusted scale. We designed the UHDRS‐For Advanced Patients (UHDRS‐FAP), in order to improve longitudinal assessment of patients at advanced disease stage. Sixty‐nine patients with a Total Functional Capacity (TFC) ≤ 5 were recruited in France and in the Netherlands. Among them, 45 patients were followed longitudinally (mean 1.6 ± 1.2 years) with the UHDRS‐FAP; 30 were also assessed with the UHDRS. Cross‐sectional analyses evaluated psychometric properties and interrater reliability of the scale. Longitudinal analyses evaluated the sensitivity to decline compared to the UHDRS. Internal consistency was higher for motor and cognitive scores than for somatic and behavioral scores (0.84, 0.91, 0.70, and 0.49, respectively). Interrater reliability was ≥ 0.88 in all scores. The somatic score, specific to the UHDRS‐FAP, declined over time, as well as motor and cognitive performance with both scales. Although performance with the 2 scales correlated, the UHDRS‐FAP appeared more sensitive to change and was the only scale that detected decline in patients with a TFC ≤ 1. Neither scale detected a significant decline in behavioral scores. The UHDRS‐FAP is reliable and more sensitive to change than the original UHDRS for cognitive and motor domains. It offers items relevant for daily care. Behavioral scores tended to decline but this may reflect the decline in the communicative abilities of the patients. © 2013 International Parkinson and Movement Disorder Society
PINK1 heterozygous mutations induce subtle alterations in dopamine‐dependent synaptic plasticity
Authors: Madeo Graziella , Schirinzi Tommaso , Martella Giuseppina , Latagliata E. Claudio , Puglisi Francesca , Shen Jie , Valente Enza Maria , Federici Mauro , Mercuri Nicola B. , Puglisi‐Allegra Stefano , Bonsi Paola , Pisani Antonio 
Published: October 2013

ABSTRACTHomozygous or compound heterozygous mutations in the phosphatase and tensin homolog‐induced putative kinase 1 (PINK1) gene are causative of autosomal recessive, early onset Parkinson's disease. Single heterozygous mutations have been detected repeatedly both in a subset of patients and in unaffected individuals, and the significance of these mutations has long been debated. Several neurophysiological studies from non‐manifesting PINK1 heterozygotes have demonstrated the existence of neural plasticity abnormalities, indicating the presence of specific endophenotypic traits in the heterozygous state. We performed a functional analysis of corticostriatal synaptic plasticity in heterozygous PINK1 knockout (PINK1+/−) mice using a multidisciplinary approach and observed that, despite normal motor behavior, repetitive activation of cortical inputs to striatal neurons failed to induce long‐term potentiation (LTP), whereas long‐term depression was normal. Although nigral dopaminergic neurons exhibited normal morphological and electrophysiological properties with normal responses to dopamine receptor activation, a significantly lower dopamine release was measured in the striatum of PINK1+/− mice compared with control mice, suggesting that a decrease in stimulus‐evoked dopamine overflow acts as a major determinant for the LTP deficit. Accordingly, pharmacological agents capable of increasing the availability of dopamine in the synaptic cleft restored normal LTP in heterozygous mice. Moreover, monoamine oxidase B inhibitors rescued physiological LTP and normal dopamine release. Our results provide novel evidence for striatal plasticity abnormalities, even in the heterozygous disease state. These alterations might be considered an endophenotype to this monogenic form of Parkinson's disease and a valid tool with which to characterize early disease stage and design possible disease‐modifying therapies. © 2013 International Parkinson and Movement Disorder Society
New results on global asymptotic stability for a class of delayed Nicholson's blowflies model
Authors: Huang Zuda 
Published: October 2013

AbstractThis paper is concerned with a class of non‐autonomous delayed Nicholson's blowflies model, which is defined on the positive function space. Under proper conditions, we employ a novel proof to establish several criteria on the global asymptotic stability of zero equilibrium point for this model. Moreover, we give an example and its numerical simulation to illustrate our main results. Copyright © 2013 John Wiley & Sons, Ltd.
Parameter estimation approach to banding artifact reduction in balanced steady‐state free precession
Authors: Björk Marcus , Ingle R. Reeve , Gudmundson Erik , Stoica Petre , Nishimura Dwight G. , Barral Joëlle K. 
Published: October 2013

PurposeThe balanced steady‐state free precession (bSSFP) pulse sequence has shown to be of great interest due to its high signal‐to‐noise ratio efficiency. However, bSSFP images often suffer from banding artifacts due to off‐resonance effects, which we aim to minimize in this article.MethodsWe present a general and fast two‐step algorithm for 1) estimating the unknowns in the bSSFP signal model from multiple phase‐cycled acquisitions, and 2) reconstructing band‐free images. The first step, linearization for off‐resonance estimation (LORE), solves the nonlinear problem approximately by a robust linear approach. The second step applies a Gauss‐Newton algorithm, initialized by LORE, to minimize the nonlinear least squares criterion. We name the full algorithm LORE‐GN.ResultsWe derive the Cramér‐Rao bound, a theoretical lower bound of the variance for any unbiased estimator, and show that LORE‐GN is statistically efficient. Furthermore, we show that simultaneous estimation of T1 and T2 from phase‐cycled bSSFP is difficult, since the Cramér‐Rao bound is high at common signal‐to‐noise ratio. Using simulated, phantom, and in vivo data, we illustrate the band‐reduction capabilities of LORE‐GN compared to other techniques, such as sum‐of‐squares.ConclusionUsing LORE‐GN we can successfully minimize banding artifacts in bSSFP. Magn Reson Med 72:880–892, 2014. © 2013 Wiley Periodicals, Inc.
Changes in taste perception and eating behavior after bariatric surgery‐induced weight loss in women
Authors: Pepino Marta Yanina , Bradley David , Eagon J. Christopher , Sullivan Shelby , Abumrad Nada A. , Klein Samuel 
Published: October 2013

ObjectiveRoux‐en‐Y gastric bypass (RYGB) surgery causes greater weight loss than laparoscopic adjustable gastric banding (LAGB). We tested the hypothesis that RYGB has weight loss‐independent effects on taste perception, which influence eating behavior and contribute to the greater weight loss.MethodsSubjects were studied before and after ∼20% weight loss induced by RYGB (n = 17) or LAGB (n = 10). The following have been evaluated: taste sensitivity for sweet, salty and savory stimuli, sucrose and monosodium glutamate (MSG) preferences, sweetness palatability, eating behavior, and expression of taste‐related genes in biopsies of fungiform papillae.ResultsWeight loss induced by both procedures caused the same decrease in: preferred sucrose concentration (−12 ± 10%), perceived sweetness of sucrose (−7 ± 5%), cravings for sweets and fast‐foods (−22 ± 5%), influence of emotions (−27 ± 5%), and external food cues (−30 ± 4%) on eating behavior, and expression of α‐gustducin in fungiform papillae (all P values <0.05). RYGB, but not LAGB, shifted sweetness palatability from pleasant to unpleasant when repetitively tasting sucrose (P = 0.05). Neither procedure affected taste detection thresholds nor MSG preferences.ConclusionsLAGB and RYGB cause similar alterations in eating behaviors, when weight loss is matched. These changes in eating behavior were not associated with changes in taste sensitivity, suggesting other, as yet unknown, mechanisms are involved.
Interdisciplinary Perspectives on Competitive Climate Strategy in Multinational Corporations
Authors: Schotter Andreas , Goodsite Michael E. 
Published: October 2013

AbstractUntil recently, corporations have taken mostly reactive positions on climate change by applying mitigation and adaptation strategies in response to imminent political or actual physical risks to their businesses. Few corporations have taken a proactive, opportunity‐seeking strategic approach to improve competitiveness over and above the mitigation and adaptation requirements set by policymakers, industry norms, or shifting consumer preferences. Considering that the climate change discussion no longer focuses on whether human activities have an impact on the changing climate, or how much impact they have, corporations should now focus on how to maximize competitiveness based on the actual and predicted climate change effects. © 2013 Wiley Periodicals, Inc.
Fracturing Writing Spaces
Authors: Lenters Kimberly , Winters Kari‐Lynn 
Published: October 2013

AbstractIn this paper, we explore the affordances of literature‐based, arts‐infused and digital media processes for students, as multimodal practices take centre stage in an English Language Arts unit on fractured fairy tales. The study takes up the challenge of addressing multimodal literacy instruction and research in ways that utilize a range of modalities. Incorporating the perspectives and multimodal texts of five students, Alvin, Adamma, Emmett, Layla and Yacoub, we highlight the highly supportive writing environment made possible for these fifth grade learners. The oral, embodied, visual, and written group explorations of the language of fairy tales, story and parody, found in fractured fairy tales, afforded the students numerous, rich opportunities to explore and experiment with language, which ultimately led to the production of individual fractured fairy tales written with a level of sophistication their teacher had not previously seen in their writing.
A Blended Approach to Reading and Writing Graphic Stories
Authors: Brown Sally 
Published: October 2013

AbstractThis article documents the experiences of a diverse group of second grade students during a nine week unit of study focused on graphic stories. The project begins as the class is immersed in reading graphic stories designed for young readers. Images, written text, and dialog are utilized to scaffold reading comprehension and to practice fluency. Then, students construct their own graphic stories based on characters from books, popular culture, and personal experiences. Each story is transformed into a digital format with narration using Photo Story. The results indicate student growth in the areas of comprehension and fluency. There is also a need to integrate new literacies with traditional to prepare students for communicating in the 21st century.
Detection of submicroscopic chromosomal aberrations by array‐based comparative genomic hybridization in fetuses with congenital heart disease
Authors: Yan Y. , Wu Q. , Zhang L. , Wang X. , Dan S. , Deng D. , Sun L. , Yao L. , Ma Y. , Wang L. 
Published: October 2013

ABSTRACTObjectivesTo evaluate the usefulness of array‐based comparative genomic hybridization (aCGH) for prenatal genetic diagnosis of congenital heart disease (CHD), with and without associated anomalies, and to explore the relationship between submicroscopic chromosomal aberrations and CHD.MethodsIn this prospective study we investigated 76 consecutive singleton fetuses with abnormal cardiac ultrasound findings, normal karyotype and negative or no fluorescence in‐situ hybridization results for 22q11.2 deletion syndrome. All pregnancies underwent aCGH in a comprehensive search for chromosomal aberrations. The relationship between copy number variations (CNVs) and CHD was determined by comparing clinical findings to chromosomal databases.ResultsCNVs that were benign or had no clinical significance were detected in 18/76 (23.7%) cases. CNVs of unknown clinical significance (i.e. VOUS) were detected in 4/76 (5.3%) cases. Pathogenic CNVs were detected in 5/76 (6.6%) cases. Fetuses with CHD and additional structural abnormalities demonstrated no difference in number of pathogenic CNVs when compared with fetuses with isolated CHD (7.4% (n = 2/27) vs 6.1% (n = 3/49), P > 0.05).ConclusionIn this study cohort, aCGH analysis significantly improved the detection of submicroscopic chromosomal aberrations in pregnancies with CHD, as compared with conventional cytogenetics. Our results suggest that aCGH can provide additional genetic information in fetuses with abnormal heart findings. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.
Speaker perception
Authors: Schweinberger Stefan R. , Kawahara Hideki , Simpson Adrian P. , Skuk Verena G. , Zäske Romi 
Published: October 2013

While humans use their voice mainly for communicating information about the world, paralinguistic cues in the voice signal convey rich dynamic information about a speaker's arousal and emotional state, and extralinguistic cues reflect more stable speaker characteristics including identity, biological sex and social gender, socioeconomic or regional background, and age. Here we review the anatomical and physiological bases for individual differences in the human voice, before discussing how recent methodological progress in voice morphing and voice synthesis has promoted research on current theoretical issues, such as how voices are mentally represented in the human brain. Special attention is dedicated to the distinction between the recognition of familiar and unfamiliar speakers, in everyday situations or in the forensic context, and on the processes and representational changes that accompany the learning of new voices. We describe how specific impairments and individual differences in voice perception could relate to specific brain correlates. Finally, we consider that voices are produced by speakers who are often visible during communication, and review recent evidence that shows how speaker perception involves dynamic face–voice integration. The representation of para‐ and extralinguistic vocal information plays a major role in person perception and social communication, could be neuronally encoded in a prototype‐referenced manner, and is subject to flexible adaptive recalibration as a result of specific perceptual experience. WIREs Cogn Sci 2014, 5:15–25. doi: 10.1002/wcs.1261This article is categorized under:

Linguistics > Language in Mind and Brain
Psychology > Perception and Psychophysics
Neuroscience > Cognition
Synthesis, Structures, and Catalytic Properties of Two ­Cobalt(II) Coordination Polymers Based on 5‐Substituted Isophthalate and Flexible Bis(benzimidazole) Co‐ligands
Authors: Qin Li , Ming Chun‐Lun , Xiao Shu‐Lin , Ma Pei‐Juan , Cui Guang‐Hua 
Published: October 2013

AbstractTwo new CoII coordination polymers, [Co(L1)0.5(hip)]n (1) and [Co(L2)(mip)·2H2O]n (2) [L1 = 1,1′‐(1,4‐butanediyl)bis‐1H‐benzimidazole, L2 = 1,3‐bis(5,6‐dimethylbenzimidazol‐1‐yl)‐2‐propanol, H2hip = 5‐hydroxyisophthalic acid, H2mip = 5‐methylisophthalic acid], were synthesized under hydrothermal conditions and structurally characterized by elemental analysis, IR spectroscopy, and X‐ray single‐crystal diffraction. Complex 1 exhibits a 3D supramolecular network constructed with 2D (4,4) layer by O–H···O hydrogen bonding. Complex 2 has 1D ladder‐like chains, which are further assembled into a 3D supramolecular framework by π–π stacking interactions. In addition, fluorescence and catalytic properties of compounds 1 and 2 were investigated in solid state.
A New Zinc(II) Coordination Polymer with a Threefold‐Interpenetrating Diamondoid Net: Synthesis, Crystal Structure and Luminescent Property
Authors: Miao Hui , Cui Yumin , Guo Feng 
Published: October 2013

AbstractThe three‐dimensional (3D) coordination polymer, [Zn(dpa)(bib)]n (1) [H2dap = diaphonic acid and bib = 1,4‐bis(imidazol‐1‐yl)benzene], was prepared by hydrothermal synthesis and characterized by single‐crystal X‐ray diffraction, FT‐IR spectroscopy, XRPD, and elemental analysis. Crystal structure determination revealed that complex 1 shows a threefold diamond topological net. Furthermore, the solid‐state luminescent property of [Zn(dpa)(bib)]n was investigated.
Spectroscopy of planetary atmospheres in our Galaxy
Authors: Tinetti Giovanna , Encrenaz Thérèse , Coustenis Athena 
Published: October 2013

Abstract
About 20 years after the discovery of the first extrasolar planet, the number of planets known has grown by three orders of magnitude, and continues to increase at neck breaking pace. For most of these planets we have little information, except for the fact that they exist and possess an address in our Galaxy. For about one third of them, we know how much they weigh, their size and their orbital parameters. For less than 20, we start to have some clues about their atmospheric temperature and composition. How do we make progress from here?
We are still far from the completion of a hypothetical Hertzsprung–Russell diagram for planets comparable to what we have for stars, and today we do not even know whether such classification will ever be possible or even meaningful for planetary objects. But one thing is clear: planetary parameters such as mass, radius and temperature alone do not explain the diversity revealed by current observations. The chemical composition of these planets is needed to trace back their formation history and evolution, as happened for the planets in our Solar System. As in situ measurements are and will remain off-limits for exoplanets, to study their chemical composition we will have to rely on remote sensing spectroscopic observations of their gaseous envelopes.
In this paper, we critically review the key achievements accomplished in the study of exoplanet atmospheres in the past ten years. We discuss possible hurdles and the way to overcome those. Finally, we review the prospects for the future. The knowledge and the experience gained with the planets in our solar system will guide our journey among those faraway worlds.
Plasma metabolomics reveals a potential panel of biomarkers for early diagnosis in acute coronary syndrome
Authors: Laborde Carlos M. , Mourino-Alvarez Laura , Posada-Ayala María , Alvarez-Llamas Gloria , Serranillos-Reus Manuel Gómez , Moreu José , Vivanco Fernando , Padial Luis R. , Barderas María G. 
Published: October 2013

Abstract

Discovery of new biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Recent advances in metabolomic technologies have drastically enhanced the possibility of improving the knowledge of its physiopathology through the identification of the altered metabolic pathways. In this study, analyses of peripheral plasma from non-ST segment elevation ACS patients and healthy controls by gas chromatography–mass spectrometry (GC–MC) permitted the identification of 15 metabolites with statistical differences (p < 0.05) between experimental groups. Additionally, validation by GC–MC and liquid chromatography–MC permitted us to identify a potential panel of biomarkers formed by 5-OH-tryptophan, 2-OH-butyric acid and 3-OH-butyric acid. This panel of biomarkers reflects the oxidative stress and the hypoxic state that suffers the myocardial cells and consequently constitutes a metabolomic signature of the atherogenesis process that could be used for early diagnosis of ACS.
Uniformity and diversity of response properties of neurons in the primary visual cortex: Selectivity for orientation, direction of motion, and stimulus size from center to far periphery
Authors: YU HSIN-HAO , ROSA MARCELLO G.P. 
Published: October 2013

AbstractAlthough the primary visual cortex (V1) is one of the most extensively studied areas of the primate brain, very little is known about how the far periphery of visual space is represented in this area. We characterized the physiological response properties of V1 neurons in anaesthetized marmoset monkeys, using high-contrast drifting gratings. Comparisons were made between cells with receptive fields located in three regions of V1, defined by eccentricity: central (3–5°), near peripheral (5–15°), and far peripheral (>50°). We found that orientation selectivity of individual cells was similar from the center to the far periphery. Nonetheless, the proportion of orientation-selective neurons was higher in central visual field representation than in the peripheral representations. In addition, there were similar proportions of cells representing all orientations, with the exception of the representation of the far periphery, where we detected a bias favoring near-horizontal orientations. The proportions of direction-selective cells were similar throughout V1. When the center/surround organization of the receptive fields was tested with gratings with varying diameters, we found that the population of neurons that was suppressed by large gratings was smaller in the far periphery, although the strength of suppression in these cells tended to be stronger. In addition, the ratio between the diameters of the excitatory centers and suppressive surrounds was similar across the entire visual field. These results suggest that, superimposed on the broad uniformity of V1, there are subtle physiological differences, which indicate that spatial information is processed differently in the central versus far peripheral visual fields.
Using index numbers for deflation in environmental accounting
Authors: Muller Nicholas Z. 
Published: October 2013

AbstractSystematic trends in the general price level of goods and services are the subject of extensive measurement and significant interest among researchers, policy makers and the general public. Dynamic price measurement is also important in environmental accounting in that real measures of augmented output are required to draw inferences on sustainability. This paper computes price indices for emissions of five air pollutants in the United States. Using marginal damages, the paper computes Paasche, Laspeyres, Fisher and Tornquist index numbers for five air pollutants spanning the period 1999–2008 for use in computing real environmental accounts. Evidence of time series heterogeneity in the marginal damages is detected: marginal damages for nitrogen oxides increase by a factor of two and marginal damages for NH3decrease by one-half. The analysis finds that nominal gross damages from air pollution in the United States decrease by 40 per cent between 1999 and 2008.
MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis
Authors: Perdomo Catalina , Campbell Joshua D. , Gerrein Joseph , Tellez Carmen S. , Garrison Carly B. , Walser Tonya C. , Drizik Eduard , Si Huiqing , Gower Adam C. , Vick Jessica , Anderlind Christina , Jackson George R. , Mankus Courtney , Schembri Frank , O’Hara Carl , Gomperts Brigitte N. , Dubinett Steven M. , Hayden Patrick , Belinsky Steven A. , Lenburg Marc E. , Spira Avrum 
Published: October 2013

Significance
MicroRNAs are small noncoding RNAs that negatively regulate gene expression and have been implicated in a variety of cellular processes. Using small RNA sequencing, we identified microRNA 4423 (miR-4423) as a primate-specific microRNA whose expression is largely restricted to airway epithelium and which functions as a regulator of airway epithelium differentiation and a repressor of lung carcinogenesis. Understanding miR-4423’s role in airway development may provide insights into primate-specific aspects of airway biology and the evolution of primate-specific tumor suppressors. Moreover, this study opens the possibility that microRNAs might be useful for the early detection of lung cancer in the proximal airway and that miR-4423 mimetics might also be used as therapeutic agents to specifically target lung cancer.