bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome following gastrointestinal tract decontamination and intravenous fluid diuresis in cats with known lily ingestion: 25 cases (2001–2010)
Authors: Bennett Alice J. , Reineke Erica L. 
Published: April 2013

Abstract
Objective—To describe the outcome of cats treated with gastrointestinal tract decontamination, IV fluid diuresis, or both after ingestion of plant material from lilies of the Lilium and Hemerocallis genera.
Design—Retrospective case series.
Animals—25 cats evaluated after ingestion of lily plants.
Procedures—Medical records of cats examined at the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania with known lily ingestion between July 2001 and April 2010 were reviewed. Inclusion in the study required evidence of lily plant ingestion within the preceding 48 hours. Type of lily ingested, time of ingestion, gastrointestinal tract decontamination procedures performed, and IV fluid diuresis were recorded. The presence or absence of acute kidney injury was determined by evaluating BUN concentration, creatinine concentration, and urine specific gravity. Outcome was defined as survival to discharge, death, or euthanasia.
Results—The time from ingestion until evaluation at the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania ranged from < 30 minutes to 48 hours. Nineteen cats received gastrointestinal tract decontamination (18 cats at our hospital and 1 cat by the referring veterinarian). Twenty-three cats were admitted to the hospital for IV fluid diuresis, supportive care, and monitoring. Seventeen of these 23 (74%) cats had normal BUN and creatinine concentrations throughout hospitalization. At the time of discharge from the hospital, 2 of the 23 (9%) hospitalized cats had an increased BUN concentration, creatinine concentration, or both. All 25 (100%) cats survived to discharge from the hospital.
Conclusions and Clinical Relevance—In this series of cats treated with gastrointestinal tract decontamination, IV fluid diuresis, or both within 48 hours after lily ingestion, the outcome was good, with a low incidence of acute kidney injury. Future studies are needed to determine the most effective gastrointestinal tract decontamination procedures and optimal duration of IV fluid therapy.
Comparison of phenylephrine administration and exercise versus phenylephrine administration and a rolling procedure for the correction of nephrosplenic entrapment of the large colon in horses: 88 cases (2004–2010)
Authors: Fultz Lisa E. , Peloso John G. , Giguère Steeve , Adams Aric R. 
Published: April 2013

Abstract
Objective—To compare the outcome of horses with nephrosplenic entrapment of the large colon (NSELC) that were treated nonsurgically by IV administration of phenylephrine and exercise with that of horses treated by IV administration of phenylephrine and a rolling procedure under general anesthesia.
Design—Retrospective case series.
Animals—88 horses with NSELC.
Procedures—Horses examined between 2004 and 2010 because of acute abdominal pain that had NSELC on the basis of findings on abdominal palpation per rectum, abdominal ultrasonography, or both were included. Medical records were reviewed to obtain information on treatment (IV administration of phenylephrine and exercise vs IV administration of phenylephrine and a rolling procedure) and outcome.
Results—Overall, 85% (75/88) of horses with NSELC responded to exercise or rolling under general anesthesia. The success rate of rolling under general anesthesia (42/50 [84%]) was significantly higher than the success rate of exercise after IV administration of phenylephrine (24/38 [63.2%]). Resolution of NSELC was achieved by rolling under general anesthesia in 8 of 14 horses that initially failed to resolve with exercise.
Conclusions and Clinical Relevance—A rolling procedure performed under general anesthesia had a higher success rate than exercise after IV phenylephrine administration for resolution of NSELC in horses, suggesting that rolling could be considered as the initial medical treatment. The rolling procedure may be labor intensive and should only be attempted in a surgical facility in the event that exploratory laparotomy is required
Description of a Weight-Bearing Method to Assess Hip Abductor and External Rotator Muscle Performance
Authors: Lee Szu-Ping , Powers Christopher 
Published: April 2013

Study Design Measurements, descriptive. Objectives To describe a weight-bearing method to assess bilateral hip abductor and external rotator muscle performance. Background The hip abductors and external rotators are important in maintaining lower extremity alignment during weight-bearing tasks. As such, there is a need for a method to assess hip muscle performance in weight bearing. Methods The weight-bearing method of assessing hip muscle performance utilized a force transducer connected to a nonstretchable fabric strap positioned around the distal ends of both thighs (proximal to the lateral epicondyles). The force generation capacity was recorded with the participants in a semi-squat position (30° of hip flexion and 50° of knee flexion). To establish the reliability of the measurement, 20 participants were tested on 2 separate days, and intraclass correlation coefficient (model 3,1) and standard error of measurement were calculated to evaluate test-retest reliability and intersession consistency. The level of agreement between the muscle performance values obtained using the weight-bearing method and the traditional non-weight-bearing method of testing hip abduction in sidelying (dynamometer) was assessed using a linear correlation model. Results The weight-bearing method of assessing hip muscle performance was reliable (intraclass correlation coefficient = 0.99; 95% confidence interval: 0.97, 0.99) and consistent (standard error of measurement, 0.02 N/kg). The measured strength using the weight-bearing method was moderately associated with hip abduction strength values measured in non-weight bearing (r = 0.75, P<.01). Conclusion The proposed weight-bearing method of assessing hip abductor and external rotator muscle performance can be used as a simple, economic, and reliable method to assess hip muscle strength. J Orthop Sports Phys Ther 2013;43(6):392–397. Epub 18 March 2013. doi:10.2519/jospt.2013.4412
Etanercept Improves Lipid Profile and Oxidative Stress Measures in Patients with Juvenile Idiopathic Arthritis
Authors: De Sanctis Sara , Marcovecchio M. Loredana , Gaspari Stefania , Del Torto Marianna , Mohn Angelika , Chiarelli Francesco , Breda Luciana 
Published: April 2013

Objective.To investigate the effect of 1-year treatment with the anti-tumor necrosis factor-α (TNF-α) drug etanercept on lipid profile and oxidative stress in children and adolescents with juvenile idiopathic arthritis (JIA).Methods.Thirty children with JIA (22 females; mean age 12.3 ± SD 5.7 yrs), all eligible for anti-TNF-α treatment, were assessed at baseline and after 6- and 12-month treatment with etanercept. Disease activity was determined using the Juvenile Arthritis Disease Activity Score (JADAS). Blood samples were drawn to measure the acute-phase reactants C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), lipids, and the proinflammatory cytokines TNF-α, interleukin-1β (IL-1β), IL-6 and interferon-γ. To measure the oxidative stress marker 8-iso-prostaglandin F2α, 24-h urine samples were collected.Results.Inflammatory indicators (CRP and ESR) and JADAS scores improved significantly after 1 year of etanercept treatment (all p < 0.001). Proinflammatory cytokines showed significant reduction during the study period (all p < 0.001). Similar reductions were detected in total cholesterol (p < 0.001), low-density lipoprotein cholesterol (p = 0.04), and triglycerides (p < 0.001), whereas no significant change was found in high-density lipoprotein cholesterol. No side effects were observed during the treatment period.Conclusion.This study shows for the first time that anti-TNF-α therapy for JIA is associated not only with a beneficial effect on clinical disease activity and inflammatory indexes, but also with improved lipid profile and oxidative stress. These findings suggest that TNF-α blockers might reduce atherosclerotic risk in children with JIA.
Et si le marketing devenait moins segmenté et plus inclusif ?
Authors: David-Ignatieff Arabella 
Published: April 2013

La segmentation permet de regrouper les consommateurs selon des critères précis afin de mieux les cibler. Cette réflexion montre comment deux exemples de segmentation, concernant les individus âgés de plus de 50 ans et les femmes ayant un surplus de poids, peuvent conduire des entreprises à négliger ou à ostraciser des marchés rentables de consommateurs. Afin d’éviter ce genre de situation, les entreprises doivent retourner aux sources du marketing en se posant la question : « À quels besoins du consommateur notre campagne de marketing répond-elle ? » Cela mènera à des campagnes plus inclusives qui tenteront de satisfaire les besoins fondamentaux de toutes les personnes, à savoir les besoins d’identité, de relation, d’utilité, d’adaptation et d’énergie.
L'institutionnalisation de l'évaluation des politiques publiques en Wallonie : une réponse propre à des influences externes
Authors: Fyalkowski Pol , Aubin David 
Published: April 2013

L’évaluation des politiques publiques représente un enjeu important dans nos sociétés confrontées à des choix complexes. En éclairant les mandataires politiques, les responsables administratifs mais aussi les citoyens sur les effets des politiques adoptées, l’évaluation peut contribuer à améliorer l’efficacité et la légitimité de l’action publique. Dans ce contexte, cet article vise à retracer et analyser le processus d’institutionnalisation de l’évaluation des politiques publiques en Wallonie en identifiant le rôle joué par trois variables explicatives : l’européanisation de l’action publique, la nouvelle gestion publique (NGP) et la crise de légitimité de l’action publique. Nos recherches tendent à montrer que les pressions externes de l’Union européenne et de l’univers de la NGP ont une influence sur l’institutionnalisation de la pratique évaluative en Wallonie.
B-Learning Tools in Engineering Education
Authors: Cancela Angeles , Maceiras Rocio , Sanchez Angel , Urrejola Santiago 
Published: April 2013

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</style> <![endif]--> <!--StartFragment--><span style="font-size: 12.0pt; font-family: &quot;Times New Roman&quot;; mso-fareast-font-family: &quot;Times New Roman&quot;; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; layout-grid-mode: line;" lang="EN-GB">The New Higher Education System implies the adoption of different education systems than the traditional ones. Therefore, many college teachers today want to use some new mechanisms to teach the matter and to find better ways of engaging students in the learning process. The objective of this work is to evaluate different learning methods from the student&rsquo;s point of view and share the authors&rsquo; experience towards a different mode of teaching. Three different learning techniques have been used on University of Vigo&rsquo;s fifth-year engineering students and the students have answered a questionnaire in order to check the effectiveness of the different methods from the students&rsquo; point of view. The results of the experience show that the use of learning methods (cooperative learning and multimedia resources) fosters student motivation and improves their retention, assimilation, understanding, and proper application of course content.</span><!--EndFragment-->
Intrarectal Immunization and IgA Antibody-Secreting Cell Homing to the Small Intestine
Authors: Agnello Davide , Denimal Damien , Lavaux Amandine , Blondeau-Germe Leslie , Lu Bao , Gerard Norma P. , Gerard Craig , Pothier Pierre 
Published: April 2013

Abstract
According to the current paradigm, lymphocyte homing to the small intestine requires the expression of two tissue-specific homing receptors, the integrin α4β7 and the CCL25 receptor CCR9. In this study, we investigated the organ distribution and the homing molecule expression of IgA Ab-secreting cells (ASCs) induced by intrarectal immunization with a particulate Ag, in comparison with other mucosal immunization routes. Intrarectal immunization induces gut-homing IgA ASCs that localize not only in the colon but also in the small intestine, although they are not responsive to CCL25, unlike IgA ASCs induced by oral immunization. The mucosal epithelial chemokine CCL28, known to attract all IgA ASCs, does not compensate for the lack of CCL25 responsiveness, because the number of Ag-specific cells is not decreased in the gut of CCR10-deficient mice immunized by the intrarectal route. However, Ag-specific IgA ASCs induced by intrarectal immunization express the integrin α4β7, and their number is considerably decreased in the gut of β7-deficient mice immunized by the intrarectal route, indicating that α4β7 enables these cells to migrate into the small intestine, even without CCL25 responsiveness. In contrast, IgA ASCs induced by intranasal immunization express low α4β7 levels and are usually excluded from the gut. Paradoxically, after intranasal immunization, Ag-specific IgA ASCs are significantly increased in the small intestine of β7-deficient mice, demonstrating that lymphocyte homing is a competitive process and that integrin α4β7 determines not only the intestinal tropism of IgA ASCs elicited in GALTs but also the intestinal exclusion of lymphocytes primed in other inductive sites.
Inoculation Dose of Mycobacterium tuberculosis Does Not Influence Priming of T Cell Responses in Lymph Nodes
Authors: Myers Amy J. , Marino Simeone , Kirschner Denise E. , Flynn JoAnne L. 
Published: April 2013

Abstract
The effect of Mycobacterium tuberculosis inocula size on T cell priming in the lymph node and effector T cells in the lung remains controversial. In this study, we used a naive mouse model, without the transfer of transgenic T cells, in conjunction with mathematical model to test whether infection with higher aerosolized inocula would lead to increased priming of M. tuberculosis–specific T cells in the lung-draining lymph node. Our data do not support that inoculum size has a measurable influence on T cell priming in the lymph nodes but is associated with more cells overall in the lung, including T cells. To account for increased T cells in the lungs, we tested several possible mechanisms, and recruitment of T cells to the lungs was most influenced by inoculum dose. We also identified IL-10 as a possible mechanism to explain the lack of influence of inoculum dose on priming of T cells in the lymph node.
Overview of Electron Crystallography of Membrane Proteins: Crystallization and Screening Strategies Using Negative Stain Electron Microscopy
Authors: Nannenga Brent L. , Iadanza Matthew G. , Vollmar Breanna S. , Gonen Tamir 
Published: April 2013

AbstractElectron cryomicroscopy, or cryoEM, is an emerging technique for studying the three‐dimensional structures of proteins and large macromolecular machines. Electron crystallography is a branch of cryoEM in which structures of proteins can be studied at resolutions that rival those achieved by X‐ray crystallography. Electron crystallography employs two‐dimensional crystals of a membrane protein embedded within a lipid bilayer. The key to a successful electron crystallographic experiment is the crystallization, or reconstitution, of the protein of interest. This unit describes ways in which protein can be expressed, purified, and reconstituted into well‐ordered two‐dimensional crystals. A protocol is also provided for negative stain electron microscopy as a tool for screening crystallization trials. When large and well‐ordered crystals are obtained, the structures of both protein and its surrounding membrane can be determined to atomic resolution. Curr. Protoc. Protein Sci. 72:17.15.1‐17.15.11. © 2013 by John Wiley & Sons, Inc.
Overview of Protein Microarrays
Authors: Sutandy F.X. Reymond , Qian Jiang , Chen Chien‐Sheng , Zhu Heng 
Published: April 2013

AbstractProtein microarray technology is an emerging field that provides a versatile platform for the characterization of hundreds of thousands of proteins in a highly parallel and high‐throughput manner. Protein microarrays are composed of two major classes: analytical and functional. In addition, tissue or cell lysates can also be fractionated and spotted on a slide to form a reverse‐phase protein microarray. Applications of protein microarrays, especially functional protein microarrays, have flourished over the past decade as the fabrication technology has matured. In this unit, advances in protein microarray technologies are reviewed, and then a series of examples are presented to illustrate the applications of analytical and functional protein microarrays in both basic and clinical research. Relevant areas of research include the detection of various binding properties of proteins, the study of protein post‐translational modifications, the analysis of host‐microbe interactions, profiling antibody specificity, and the identification of biomarkers in autoimmune diseases. Curr. Protoc. Protein Sci. 72:27.1.1‐27.1.16. © 2013 by John Wiley & Sons, Inc.
Protein Microarrays for Identification of Novel Extracellular Protein‐Protein Interactions
Authors: Tom Irene , Lewin‐Koh Nicholas , Ramani Sree R. , Gonzalez Lino C. 
Published: April 2013

AbstractFunctional protein microarrays offer the capability for high‐throughput protein interaction analysis and have long promised to be a powerful tool for understanding protein interactions at the proteome scale. Although popular techniques for protein‐protein interaction mapping like yeast‐two‐hybrid and affinity‐purification mass spectrometry have performed well for identifying intracellular protein‐protein interactions, the study of interactions between extracellular proteins has remained challenging for these methods. Instead, the use of protein microarrays appears to be a robust and efficient method for the identification of interactions among the members of this class of protein. This unit describes methods for extracellular protein microarray production, screening, and analysis. A protocol is described for enhanced detection of low‐affinity interactions by generating multivalent complexes using Fc‐fusion bait proteins and protein A microbeads, along with a statistical method for hit scoring and identification of nonspecific interactions. Curr. Protoc. Protein Sci. 72:27.3.1‐27.3.24. © 2013 by John Wiley & Sons, Inc.
Mechanical Properties of Solid‐Sintered Porous Silicon Carbide Ceramics
Authors: Zuo Kai‐Hui , Zeng Yu‐Ping , Jiang Dongliang 
Published: April 2013

AbstractThe freeze‐drying combining solid sintering is a good method to fabricate porous SiC ceramics with good high temperature mechanical properties. Though SiC ceramics are sintered at a high temperature of 2150 °C, there are still large quantity of macropores generated by sublimating large ice crystals and micropores in the ceramic wall caused by small ice crystals sublimating, SiC particles stacking, and burning out of polyvinyl alcohol (PVA). The content of PVA affects the microstructure and strength. As increasing the content of PVA, the size of pores caused by sublimating the ice crystals decreases while both open porosity and room temperature strength increase. After being treated at a temperature of 1200 and 1500 °C, the ceramics exhibit good thermal shock damage resistance.
Scanning Near‐Field Microwave Microscopy of VO2 and Chemical Vapor Deposition Graphene
Authors: Tselev Alexander , Lavrik Nickolay V. , Kolmakov Andrei , Kalinin Sergei V. 
Published: April 2013

AbstractNear‐field scanning microwave microscopy (SMM) is a near‐field technique, which enables probing local electric properties of materials, i.e., complex permittivity. Recently, this technique was incorporated into a commercially available atomic force microscope (AFM), providing a new powerful imaging mode in the suite of AFM techniques. AFM probe‐surface distance control allows routine acquisition of near‐field microwave images with a lateral resolution better than 100 nm, which was previously unattainable. In this paper, work performed with an AFM‐based SMM system at the Center for Nanophase Materials Sciences at ORNL is reviewed. As an introduction, a brief general overview of the near‐field microwave microscopy is provided followed by a description of the SMM system. Application of the technique to studies of metal‐insulator phase transition in single‐crystalline nanoplatelets of vanadium dioxide is illustrated. Further, the capabilities of SMM in its application to imaging of conductivity inhomogeneities in single‐ and few‐layer graphene samples grown via different chemical vapor deposition (CVD) routes is demonstrated. The imaging of graphene illustrates the specific nature of contrast in the SMM, where the signal is described by complex numbers. To facilitate the interpretation of the contrast, a simple graphical scheme inspired by standard Nyquist plots is proposed.