bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Dysfunction as a Marker of Cardiovascular Disease in Males With 50 or More Years of Type 1 Diabetes
Authors: Turek Sara J. , Hastings Stephanie M. , Sun Jennifer K. , King George L. , Keenan Hillary A. 
Published: June 2013

OBJECTIVE
Vascular dysfunction is a major contributor to diabetes complications. It is also the primary physiologic cause of erectile dysfunction and considered an independent predictor of cardiovascular disease (CVD) in males over age 40 years. A cohort of individuals with 50 or more years of type 1 diabetes, Joslin Medalists, have low rates of small but not large vessel complications. This study aims to identify the prevalence and longitudinal association of sexual dysfunction (SD) with CVD in Joslin Medalists.

RESEARCH DESIGN AND METHODS
Description and association of self-assessment of SD in males of the Medalist cohort by self-reported sexual problems with CVD. SD is validated through the use of the abbreviated International Index of Erectile Dysfunction (IIEF).

RESULTS
Of 301 males in the Medalist Study, 69.8% reported a history of SD. Unadjusted risk factors included elevated glycated hemoglobin (HbA1c) (P = 0.02), elevated BMI (P = 0.03), higher total cholesterol (P = 0.02), lower HDL (P &lt; 0.01), and increased levels of interleukin-6 (P = 0.03). SD was independently associated with CVD (age-, HbA1c-, and BMI-adjusted OR 1.9 [95% CI 1.0–3.5]). In adjusted analyses, retinal, neural, and renal complications were not associated (P &gt; 0.05) with SD. Current report of SD (IIEF score ≤17) in a subset of Medalists was significantly correlated with self-reported longitudinal SD.

CONCLUSIONS
SD in those with extreme-duration type 1 diabetes is independently associated with CVD, representing a large-vessel pattern. The findings suggest that SD may predict CVD in those with type 1 diabetes of long duration. These individuals have also been found to be relatively free of microvascular complications.
Using distributed temperature sensors to monitor an Antarctic ice shelf and sub-ice-shelf cavity
Authors: Tyler S.W. , Holland D.M. , Zagorodnov V. , Stern A.A. , Sladek C. , Kobs S. , White S. , Suárez F. , Bryenton J. 
Published: June 2013

AbstractMonitoring of ice-shelf and sub-ice-shelf ocean temperatures represents an important component in understanding ice-sheet stability. Continuous monitoring is challenging due to difficult surface access, difficulties in penetrating the ice shelf, and the need for long-term operation of non-recoverable sensors. We aim to develop rapid lightweight drilling and near-continuous fiber-optic temperature-monitoring methods to meet these challenges. During November 2011, two instrumented moorings were installed within and below the McMurdo Ice Shelf (a sub-region of the Ross Ice Shelf, Antarctica) at Windless Bight. We used a combination of ice coring for the upper portion of each shelf borehole and hot-point drilling for penetration into the ocean. The boreholes provided temporary access to the ice-shelf cavity, into which distributed temperature sensing (DTS) fiber-optic cables and conventional pressure/temperature transducers were installed. The DTS moorings provided near-continuous (in time and depth) observations of ice and ocean temperatures to a depth of almost 800 m beneath the ice-shelf surface. Data received document the presence of near-freezing water throughout the cavity from November through January, followed by an influx of warmer water reaching ∼150 m beneath the ice-shelf base during February and March. The observations demonstrate prospects for achieving much higher spatial sampling of temperature than more conventional oceanographic moorings.
Observations psychanalytiques concernant les périodes de créativité d'un jeune savant
Authors: Sonnenfeld-Schiller Ludwig , Dupont Judith 
Published: June 2013

À partir d’une observation clinique très précise, l’auteur s’intéresse à la genèse de la pensée intuitive, au rôle de la sublimation, et à la « neutralisation des énergies agressives » et libidinales qui s’y déploient. Il décrit les moments d’analyse de différentes périodes de créativité, reliées en partie à certains moments de l’histoire psychique du patient ; et il s’attache à comprendre et à analyser les phénomènes accompagnant l’expérience de « transformer le familier en étrange et l’étrange en familier, l’abstrait en concret, et le concret en une abstraction ».
Au-delà du transfert et de l'interprétation
Authors: Greenson Ralph R. , Dupont Judith 
Published: June 2013

C’est un article surprenant pour son époque, car l’auteur parle comme s’il avait lu toute l’œuvre de Ferenczi, jusqu’au Journal clinique et sa correspondance avec Freud. En fait, il a eu le courage de lire dans les conséquences de ses propres interventions et comportements, retrouvant ainsi par lui-même le fameux « Sans sympathie, pas de guérison » du Journal clinique . Par ailleurs, Greenson a aussi pressenti que toute l’idée qu’on se faisait de la formation psychanalytique devait être repensée en fonction de ces propositions. En 1971, l’état d’esprit prôné par Greenson a dû sembler révolutionnaire.
À la mémoire de D. W. Winnicott
Authors: Milner Marion , Dupont Judith 
Published: June 2013

Une des premières phrases de Winnicott citées par Marion Milner pourrait résumer à elle seule une grande partie de son texte : « Ce que vous allez tirer de moi, vous devrez l’extraire du chaos. » Elle dit qu’étant une visuelle, les choses lui apparaissent par images. Et c’est ainsi qu’elle s’exprime dans la première partie de son article. La seconde résume ce qu’elle a appris de Winnicott ou ce qui l’a impressionnée dans ses façons de penser et de faire. Pour y accéder, il est bon de recourir à la méthode recommandée...
Les points de vue de Poincaré sur la « mécanique nouvelle » et leurs rapports à l'enseignement et à sa pratique scientifique
Authors: Bracco Christian , Provost Jean-Pierre 
Published: June 2013

Si Henri Poincaré a consacré un seul article scientifique à la « mécanique nouvelle » en 1905 – intitulé « La dynamique de l’électron » et connu sous le nom de Mémoire de Palerme , que nous avons analysé en 2009 dans cette revue –, il s’est cependant exprimé à son sujet à plusieurs reprises dans des ouvrages à grande diffusion. Ces derniers ont parfois suscité des jugements critiques sur sa compréhension de la relativité, par exemple concernant l’« hypothèse supplémentaire » de la contraction des longueurs, ou encore sa préférence affichée à la fin de conférences pour la mécanique newtonienne « pour ne pas troubler [nos] vieilles habitudes ». Se pose donc naturellement la question des rapports entre le Mémoire (œuvre scientifique), ces textes de vulgarisation des sciences et de leurs méthodes, et la « philosophie » ou l’épistémologie de Poincaré. Si les études sur sa « philosophie » et sa conception des mathématiques, en particulier de la géométrie, sont bien documentées, il nous a semblé que ce n’était pas le cas pour la mécanique. Nous montrerons qu’on ne peut lire les textes généraux de Poincaré sur la mécanique nouvelle en faisant abstraction des liens qui l’unissent à l’enseignement, en particulier dans le contexte de la réforme Leygues de 1902 de l’enseignement secondaire en France. Nous verrons que Poincaré ne fait en général dans ces textes qu’exposer et illustrer pédagogiquement la démarche historique de Hendrik-Antoon Lorentz, afin de familiariser son lectorat avec les nouvelles connaissances et sans reprendre ses propres apports théoriques du Mémoire , et que ses conclusions ne concernent que l’enseignement. Compte tenu de son importance et des questionnements qu’elle suscite encore aujourd’hui, nous revenons sur sa conférence « L’espace et le temps » de 1912. Elle témoigne de l’influence profonde de la « relativité physique » (de Lorentz) sur sa vision de la géométrie (appel aux lois physiques plutôt qu’aux instruments pour définir le groupe pertinent) et sur la signification du principe de relativité (existence de petits mondes indépendants) ; elle permet de mieux envisager ce qu’aurait pu être sa position vis-à-vis de la théorie de la relativité générale qui allait naître trois ans après.
Body Mass Index is not an Independent Predictor for Missed Injury on Chest X-ray compared with Chest Computed Tomography
Authors: Anand Rahul , Aboutanos Michel , Ivatury Rao , Vanguri Poornima 
Published: June 2013

ABSTRACT

Objective
Obesity is a risk factor for morbidity and mortality in the polytraumatized patient. The aim of this study is to determine if obesity is an independent risk factor for missed injury in chest X-ray after trauma.

Materials and methods
Institutional Review Board approval was obtained. We performed a retrospective review of patients who presented to a level one trauma center as the higher acuity alerts from September 2010 to July 2011. We compared the chest X-ray with the chest computed tomography (CT) findings. Variables, such as age, BMI, mechanism, admission to the ICU and mortality during the same hospital stay, were evaluated.

Results
A total of 224 patients met these criteria. The majority of patients were of male gender (79%). Average age was 40 years. Average ISS was 19.7. Mean BMI was 26.7 with 103 patients with BMI < 25 and with 123 patients with BMI >25. Mechanisms included blunt (n = 167), penetrating (n = 50) and burns (n = 7). A total of 123 patients (54.4%) had undiagnosed thoracic injuries by chest X-ray that were found on chest CT scan. Eighty-five percent of patients with missed injuries on chest X-ray required ICU admission as a result of the thoracic trauma. Missed injuries were as follows; rib fractures with or without flail chest (n = 62), pneumothorax (n = 40), hemothorax (n = 42), sternal fracture (n = 15), pulmonary lacerations/contusion (n = 60), great vessel injuries (n = 6), and blunt ventricular rupture (n = 1). Strikingly, there was no significant difference in missed injury, ICU admission or mortality when obese patients were compared to nonobese patients.

Conclusion
Chest X-ray undermines the degree of injury in blunt trauma patients. BMI is not an independent predictor of missed injury, ICU admission or mortality during the same hospital stay.

How to cite this article
Vanguri P, Anand R, Aboutanos M, Ivatury R, Ferrada P. Body Mass Index is not an Independent Predictor for Missed Injury on Chest X-ray compared with Chest Computed Tomography. Panam J Trauma Critical Care Emerg Surg 2013;2(1):45-48.
Análise da Gasometria e dos Níveis de Lactato Na Hipertensão Intra-abdominal Associada à Sepse Abdominal: Modelo Experimental em Ratos
Authors: Rojas Pedro Hurtado , Tannous Luana Alves , Bahten Luiz C Von , Villegas Felipe Castro , Gasparetto Juliano 
Published: June 2013

RESUMO

Introdução
A hipertensão intra-abdominal e a sepse são condições clínicas de grande importância e alta prevalência em pacientes criticamente enfermos. O diagnóstico precoce permite um tratamento adequado e a melhora do prognóstico dos doentes.

Objetivo
O objetivo do estudo foi analisar os níveis de lactato e os componentes da gasometria em ratos submetidos à sepse e à hipertensão intra-abdominal.

Método
O experimento utilizou 40 ratos da linhagem Wistar divididos em 4 grupos: controle, grupo sepse, grupo hipertensão intra-abdominal e grupo sepse + hipertensão intra-abdominal. A sepse foi induzida pela ligadura e punção do ceco e a hipertensão intra-abdominal foi gerada pela injeção intraperitoneal de gelatina fluída modificada para manutenção de uma pressão de 15 mm Hg durante o tempo de observação de 6 horas. Após esse período, uma dosagem de lactato e gasometria mista foram obtidas por punção intracardíaca e a eutanásia ocorreu por macrodose anestésica.

Resultados
Os resultados da comparação do grupo controle com o grupo hipertensão intra-abdominal e hipertensão intra-abdominal + sepse mostraram diferença significativa (p < 0,001) nos valores de pH, excesso de base e bicarbonato, definindo acidose metabólica nos dois grupos do experimento. Não houve diferença dos níveis de lactato entre os grupos (p > 0,4). A comparação entre os parâmetros gasométricos do grupo controle e do grupo sepse não foi significativa para demonstrar acidose metabólica.

Conclusão
A gasometria é um marcador precoce e efetivo para hipoperfusão tecidual em ratos submetidos à hipertensão intra-abdominal.
MaxSUMO: A New Expert Approach for Evaluating Mobility Management Projects
Authors: Van Acker Veronique , Van Cauwenberge Begga , Witlox Frank 
Published: June 2013

There is need for better understanding of how mobility management interventions work and how they affect the individuals’ modal choice decisions, as well as need for robust evaluation techniques allowing any behavioural changes to be observed. Changing individual’s behaviour is not a one-step process and any evaluation methodology should account for this. A new standardized expert evaluation resource MaxSUMO takes this step-wise process into account. MaxSUMO is based on a new theoretical behavioural change model MaxSEM which measures individuals’ stage positions (their susceptibility to change behaviour) and stage movement (progression towards actual behavioural change). This paper illustrates the use of MaxSUMO by the evaluation of the mobility campaign “I keep moving, even without my car” undertaken by the City of Ghent.
Order-Parameter Model for Synergetic Theory-based Railway Freight System and Evolution in China
Authors: Feng Fenling , Yang Liuen , Lan Dan 
Published: June 2013

We investigate the synergetic nature and complexity of the railway freight system and select 13 parameters (railway fixed asset investment, GDP, railway’s revenue kilometers, etc.) as the system’s state variables. By using method of least square and method of external function, we build an order-parameter model for synergetic theory-based railway freight system, which will potentially support the studies on the railway freight system’s evolution. Our result shows that railway fixed asset investment is the order-parameter that governs the evolution of railway freight system: the average random fluctuation parameter is 0.7060, which means that the mean fluctuation period of railway freight system is 9 years. Evolution of the railway freight system is a gradual process with abrupt changes from time to time.
Enzymatic Hydrolysis of Alkaline Pretreated Coconut Coir
Authors: Fatmawati Akbarningrum , Agustriyanto Rudy , Liasari Yusnita 
Published: June 2013

The purpose of this research is to study the effect of concentration and temperature on the cellulose and lignin content, and the reducing sugars produced in the enzymatic hydrolysis of coconut coir. In this research, the coconut coir is pretreated using 3%, 7%, and 11% NaOH solution at 60oC, 80oC, and 100oC. The pretreated coir were assayed by measuring the amount of cellulose and lignin and then hydrolysed using Celluclast and Novozyme 188 under various temperature (30oC, 40oC, 50oC) and pH (3, 4, 5). The hydrolysis results were assayed for the reducing sugar content. The results showed that the alkaline delignification was effective to reduce lignin and to increase the cellulose content of the coir. The best delignification condition was observed at 11% NaOH solution and 100oC which removed 14,53% of lignin and increased the cellulose content up to 50,23%. The best condition of the enzymatic hydrolysis was obtained at 50oC and pH 4 which produced 7,57 gr/L reducing sugar. © 2013 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Improved Stabilities of Immobilized Glucoamylase on Functionalized Mesoporous Silica Synthesised using Decane as Swelling Agent
Authors: George Reni , Gopinath Sanjay , Sugunan Sankaran 
Published: June 2013

Ordered mesoporous silica, with high porosity was used to immobilize glucoamylase via adsorption and covalent binding. Immobilization of glucoamylase within mesoporous silica was successfully achieved, resulting in catalytically high efficiency during starch hydrolysis. In this study, mesoporous silica was functionalized by co-condensation of tetraethoxysilane (TEOS) with organosilane (3-aminopropyl) triethoxysilane (APTES) in a wide range of molar ratios of APTES: TEOS in the presence of triblock copolymer P123 under acidic hydrothermal conditions. The prepared materials were characterized by Small angle XRD, Nitrogen adsorption – desorption and 29Si MAS solid state NMR. N2 desorption studies showed that pore size distribution decreases due to pore blockage after functionalization and enzyme immobilization. Small angle XRD and 29Si MAS NMR study reveals mesophase formation and Si environment of the materials. The main aim of our work was to study the catalytical activity, effect of pH, temperature storage stability and reusability of covalently bound glucoamylase on mesoporous silica support. The result shows that the stability of enzyme can be enhanced by immobilization. © 2013 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Activities of Heterogeneous Acid-Base Catalysts for Fragrances Synthesis: A Review
Authors: Hartati Hartati , Santoso Mardi , Triwahyono Sugeng , Prasetyoko Didik 
Published: June 2013

This paper reviews various types of heterogeneous acid-base catalysts for fragrances preparation. Catalytic activities of various types of heterogeneous acid and base catalysts in fragrances preparation, i.e. non-zeolitic, zeolitic, and mesoporous molecular sieves have been reported. Generally, heterogeneous acid catalysts are commonly used in fragrance synthesis as compared to heterogeneous base catalysts. Heteropoly acids and hydrotalcites type catalysts are widely used as heterogeneous acid and base catalysts, respectively. © 2013 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Preparation and Characterization of Acid and Alkaline Treated Kaolin Clay
Authors: Kumar Sachin , Panda Achyut Kumar , Singh R. K. 
Published: June 2013

Kaolin was refluxed with HNO3, HCl, H3PO4, CH3COOH, and NaOH of 3M concentration at 110 °C for 4 hours followed by calcination at 550 °C for 2 hours. The physico-chemical characteristics of resulted leached kaolinite clay were studied by XRF, XRD, FTIR, TGA, DTA, SEM and N2 adsorption techniques. XRF and FTIR study indicate that acid treatment under reflux conditions lead to the removal of the octahedral Al3+ cations along with other impurities. XRD of acid treated clay shows that, the peak intensity was found to decrease. Extent of leaching of Al3+ ions is different for different acid/base treatment. The acid treatment increased the Si/Al ratio, surface area and pore volume of the clay. Thus, the treated kaolin clay can be used as promising adsorbent and catalyst supports. © 2013 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Synthesis and Characterization of Ag/Ce1-xMnxO2-δ Oxidation Catalysts
Authors: Alami David , Bulavin Viktor 
Published: June 2013

The aim of this work was to obtain samples of Ag - doped manganese-cerium mixed oxides and explore their characteristics. Six catalysts were prepared by the co-precipitation process followed by impregnation method for Ag incorporation. These catalysts were characterized in particular by means of TEM, XRD, TPR and examined on the reaction of hydrogen peroxide catalytic decomposition. The samples obtained were solid solution nanoparticle agglomerates with irregular surface morphology. The results pointed out that the highest activity in oxidation reactions should possess Ag/Ce0.23Mn0.77O2-δ catalyst. © 2013 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Drug Interaction Assessment Strategies: Small Molecules versus Therapeutic Proteins
Authors: Dallas Shannon , Sensenhauser Carlo , Chattopadhyay Souvik , Silva Jose 
Published: June 2013

AbstractThis chapter is not intended to give an expansive and detailed review of all ofthe methods and assays used for drug‐drug interaction (DDI) assessment during small molecule drug (SMD) development because this has already been accomplished by others in the field. Rather, general concepts and methods will be discussed for some of the typical assays undertaken in SMD development, including whether these methods can be, should be, or already have been applied in the context of therapeutic protein (TP)‐DI assessments. This chapter serves as a starting point for understanding the complexity and difficulties in assessing TP‐DIs.
Statistical Considerations in Assessing Drug–Drug Interactions for Therapeutic Biologics
Authors: Hu Chuanpu , Zhou Honghui 
Published: June 2013

Abstract

Therapeutic biologics have different mechanisms of action from small molecules, usually making drug–drug interactions (DDIs) less likely, although this may depend on the specific circumstances. That is, the
a priori
expectation of specific DDIs is different with therapeutic biologics. In addition, therapeutic biologics usually have long half‐lives, preventing the effective use of the usual crossover trials to assess drug–drug interactions. These issues influence the design and analysis of DDI assessments. Furthermore, population pharmacokinetics modeling has been used increasingly in drug development and has promising potential in DDI assessment. This chapter discusses the associated statistical issues, particularly to ensure appropriate power and type I error.
Scientific Perspectives on Therapeutic Protein Drug–Drug Interaction Assessments
Authors: Zhao Hong , Zhang Lei , Reynolds Kellie , Huang Shiew‐Mei 
Published: June 2013

Abstract
The purpose of this chapter is to describe our review of the literature on drug interactions involving therapeutic proteins (TPs), the FDA's expanded recommendations on TP‐drug–drug interactions (DDIs) in the updated draft drug interaction guidance, and FDA‐approved product labels that include TP‐DDI information. The information presented in this chapter includes the following: TPs with drug interaction studies conducted during product development; types of study designs used to evaluate TP‐DDIs; and impact of study results on product label.
Drug–Drug Interactions for Etanercept—A Fusion Protein
Authors: Korth‐Bradley Joan 
Published: June 2013

Abstract
The treatment of immune‐mediated inflammatory diseases, such as rheumatoid arthritis, psoriasis, and psoriatic arthritis, has been changed with the introduction of biological agents in the 1990s. Previously available biological agents, such as insulin, were replacements for endogenous proteins that were missing in patients with diabetes, while newer agents such as etanercept were constructs not found in nature.
In this case study of drug–drug interaction assessments for etanercept, a fusion protein targeting tumor necrosis factor α (TNF‐α) used in the treatment of several immune‐mediated inflammatory diseases, background information about etanercept will be discussed, followed by a general assessment on the likelihood of drug interactions with fusion proteins such as etanercept. Finally, the results of specificetanercept–drug interaction investigations will be discussed.
Drug Interactions for Growth Factors and Hormones
Authors: Wang Yow‐Ming C. , Kakkar Tarundeep 
Published: June 2013

AbstractThe focus of this chapter is on four recombinant growth factor products (erythropoietins, G‐CSF, KGF, and thrombopoietins) and three hormone products (glucagon,somatropin, and pegvisomant). We compiled the information related to drug interactions found in scientific publications and regulatory agency approved labeling documents. We reference U.S. prescribing information (PI) from the Drugs@FDA website and European summary of product characteristics (SPC) from the European Medicines Agency (EMA)'s website for European public assessment reports (EPARs). In addition, we gathered information from manufacturers and other interest groups that also post up‐to‐date labeling documents on their product websites.