bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Transplantation of Mesenchymal Stem Cells Protects the Heart Against Ischemia-Reperfusion Injury
Authors: Preda Mihai Bogdan , Rønningen Torunn , Burlacu Alexandrina , Simionescu Maya , Moskaug Jan Øivind , Valen Guro 
Published: February 2014

Abstract
Cardioprotection can be evoked through extracardiac approaches. This prompted us to investigate whether remote transplantation of stem cells confers protection of the heart against ischemic injury. The cardioprotective effect of subcutaneous transplantation of naïve versus heme oxygenase-1 (HMOX-1)-overexpressing mouse mesenchymal stem cells (MSC) to mice was investigated in hearts subjected to ischemia-reperfusion in a Langendorff perfusion system. Mice were transplanted into the interscapular region with naïve or HMOX-1 transfected MSC isolated from transgenic luciferase reporter mice and compared to sham-treated animals. The fate of transplanted cells was followed by in vivo bioluminescence imaging, revealing that MSC proliferated, but did not migrate detectably from the injection site. Ex vivo analysis of the hearts showed that remote transplantation of mouse adipose-derived MSC (mASC) resulted in smaller infarcts and improved cardiac function after ischemia-reperfusion compared to sham-treated mice. Although HMOX-1 overexpression conferred cytoprotective effects on mASC against oxidative stress in vitro, no additive beneficial effect of HMOX-1 transfection was noted on the ischemic heart. Subcutaneous transplantation of MSC also improved left ventricular function when transplanted in vivo after myocardial infarction. Plasma analysis and gene expression profile of naïve- and HMOX-1-mASC after transplantation pointed toward pentraxin 3 as a possible factor involved in the remote cardioprotective effect of mASC. These results have significant implications for understanding the behavior of stem cells after transplantation and development of safe and noninvasive cellular therapies with clinical applications. Remote transplantation of MSC can be considered as an alternative procedure to induce cardioprotection. Stem Cells 2014;32:2123–2134
Two Zinc(II) Coordination Polymers of Tetrazolate‐5‐carboxylate with Self‐penetrating Three‐dimensional Nets: Synthesis, Structure, and Luminescence Properties
Authors: Jia Qin‐Xiang , Tian Hua , Gao En‐Qing 
Published: February 2014

AbstractTwo coordination compounds of the ligand tetrazolate‐5‐carboxylate (tzc) with zinc(II), namely, [Zn2(tzc)2(bpp)] (1) and [Zn2(tzc)2(bpea)] (2) [bpp = 1,3‐bis(4‐pyridyl)propane, bpea = 1,2‐bis(4‐pyridyl)ethane] were synthesized by hydrothermal methods involving the in situ generation of the ligand from sodium ethyl tetrazolate‐5‐carboxylate. Both compounds 1 and 2 exhibit a three‐dimensional structure with 3,4‐connected self‐penetrating net topology in which two‐dimensional ZnII‐tzc layers are interlinked by the bpp or bpea spacers, with the tzc ligand being in the μ3‐N1,O1:N4,O2:N2 coordination mode. The luminescence properties of 1 and 2 were also investigated.
Local Melting of Charge Ordering in CaBaCo4O7 by Sr‐Doping
Authors: Seikh Md. Motin , Pralong Valérie , Caignaert Vincent , Raveau Bernard 
Published: February 2014

AbstractThe isovalent substitution of strontium for barium in CaBaCo4O7 destroys the ferrimagnetism in a striking way though it keeps the same orthorhombic crystal symmetry and cobalt valence as the parent phase. The gradual weakening of ferrimagnetism in CaBa1–xSrxCo4O7 (0 < x ≤ 0.10) leaves place to magnetic frustration together with antiferrimagnetism. The phase separation that appears, due to the strong competition between long range ferrimagnetic ordering and magnetic frustration, is interpreted by local melting of charge ordering. The latter originates from local structural distortion around the Ba(Sr) site. The dynamic scaling theory, τ = τ0(Tf/Tg – 1)–zv, suggests that the frustrated magnetic phase is cluster glass in nature with strongly interacting spins. This finding reveals that the orthorhombic symmetry in CaBaCo4O7 is not a sufficient condition to manifest ferrimagnetic ordering.
Zur Reaktion von 2,3‐Dihydro‐1,3,4,5‐tetraisopropylimidazol‐2‐yliden (Carb) mit Iod. Die Kristallstruktur von {[Carb–I3–Carb]I·2Carb‐I2·2CH2Cl2}
Authors: Göhner Martin , Kuhn Norbert , Ströbele Markus 
Published: February 2014

AbstractFrom the reaction of 2,3‐dihydro‐1,3,4,5‐tetraisopropylimidazol‐2‐ylidene (4) (Carb) with iodine a compound of composition Carb·I2 was obtained. Crystals were isolated from dichloromethane and the X‐ray structure analysis revealed the presence of both Carb‐I2 (6) and [Carb–I3–Carb]I (7) moieties including disordered solvent according to the composition of {[Carb–I3–Carb]I·2Carb‐I2·2CH2Cl2} (5).
Synthesis of magneto-sensitive iron-containing nanoparticles by yeasts
Authors: Vainshtein Mikhail , Belova Natalia , Kulakovskaya Tatiana , Suzina Natalia , Sorokin Vladimir 
Published: February 2014

AbstractIndustrial production of magneto-sensitive nanoparticles, which can be used in the production of target drug delivery carriers, is a subject of interest for biotechnology and microbiology. Synthesis of these nanoparticles by microorganisms has been described only for bacterial species. At the same time, it is well known that yeasts can form various metal-containing nanoparticles used, for instance, in semiconductors, etc. This paper describes the first results of the biosynthesis of magneto-sensitive nanoparticles by yeasts. The organisms we used—Saccharomyces cerevisiae and Cryptococcus humicola—represented two different genera. Magneto-sensitive nanoparticles were synthesized at room temperature in bench-scale experiments. The study included transmission electron microscopy of the yeast cells and their energy dispersive spectrum analyses and revealed the presence of iron-containing nanoparticles. Both yeast cultures synthesized nanoparticles at high concentrations of dissolved iron. Electron microscopy showed that nanoparticles were associated mainly with the yeast cell wall. Formation of magneto-sensitive nanoparticles was studied under conditions of applied magnetic fields; a possible stimulating role of magnetic field is suggested. On the whole, the paper reports a novel approach to green biosynthesis of magneto-sensitive nanoparticles.
Content of Antioxidants, Antioxidant Capacity and Oxidative Stability of Grape Seed Oil Obtained by Ultra Sound Assisted Extraction
Authors: Malićanin Marko , Rac Vladislav , Antić Vesna , Antić Mališa , Palade Laurentiu Mihai , Kefalas Panagiotis , Rakić Vesna 
Published: February 2014

AbstractThe goal of this work was to investigate the relationship between antioxidants’ content and the oxidative stabilities of grape seed oils obtained from the Cabernet Sauvignon variety. The samples of grape seed oils were obtained by ultrasound assisted extraction. The time of extraction was varied, while the other relevant parameters: extraction temperature, solvent to solid ratio and sonication power were kept constant. For the sake of comparison, the extraction was also done using the conventional Soxhlet method. For all the oil samples obtained, the contents of total phenolic compounds (TPC), α‐tocopherol and fatty acids were determined using relevant analytic methods. Importantly, in the present study, the modern analytical techniques for estimation of antioxidant capacity (measuring the chemiluminescence intensity of a luminol‐hemin solution) and oxidative stability [differential scanning calorimetry (DSC), coupled with thermogravimetry (TG)] were proposed. The obtained results prove that ultrasonic irradiation enables effective extraction of grape seed oil. It was shown that the extractive yields and the amounts of total phenolic compounds and α‐tocopherol increase with time of extraction; the optimum time was determined. Results obtained in this work show that, for both oxidative stability and antioxidant capacity, TPC have a more important role then α‐tocopherol.
Integration of Tibetan Plateau ice-core temperature records and the influence of atmospheric circulation on isotopic signals in the past century
Authors: Yang Xiaoxin , Yao Tandong , Joswiak Daniel , Yao Ping 
Published: February 2014

AbstractTemperature signals in ice-core δ18O on the Tibetan Plateau (TP), particularly in the central and southern parts, continue to be debated because of the large scale of atmospheric circulation. This study presents ten ice-core δ18O records at an annual resolution, with four (Malan, Muztagata, Guliya, and Dunde) in the northern, three (Puruogangri, Geladaindong, Tanggula) in the central and three (Noijin Kangsang, Dasuopu, East Rongbuk) in the southern TP. Integration shows commonly increasing trends in δ18O in the past century, featuring the largest one in the northern, a moderate one in the central and the smallest one in the southern TP, which are all consistent with ground-based measurements of temperature. The influence of atmospheric circulation on isotopic signals in the past century was discussed through the analysis of El Niño/Southern Oscillation (ENSO), and of possible connections between sea surface temperature (SST) and the different increasing trends in both ice-core δ18O and temperature. Particularly, El Niño and the corresponding warm Bay of Bengal (BOB) SST enhance the TP ice-core isotopic enrichment, while La Niña, or corresponding cold BOB SST, causes depletion. This thus suggests a potential for reconstructing the ENSO history from the TP ice-core δ18O.
Second-trimester maternal distress increases the risk of small for gestational age
Authors: Khashan A. S. , Everard C. , McCowan L. M. E. , Dekker G. , Moss-Morris R. , Baker P. N. , Poston L. , Walker J. J. , Kenny L. C. 
Published: February 2014

BackgroundThe effect of prenatal distress on the risk of a small for gestational age (SGA) infant is uncertain. We have addressed the influences of prenatal stress, anxiety and depression on the risk of SGA. We also examined the effects of infant sex and timing of distress during pregnancy on any observed associations.MethodThe study population comprised 5606 healthy nulliparous pregnant women who participated in the international prospective Screening for Obstetric and Pregnancy Endpoints (SCOPE) study. Women completed the Perceived Stress Scale (PSS), the short form of the Spielberger State–Trait Anxiety Inventory (STAI) and the Edinburgh Postnatal Depression Scale (EPDS) at 15 ± 1 and 20 ± 1 weeks' gestation. SGA was defined as birthweight below the 10th customized percentile. Logistic regression was used for data analysis, adjusting for several potential confounders such as maternal age, body mass index (BMI), smoking, socio-economic status and physical exercise.ResultsThe risk of SGA was increased in relation to mild [adjusted odds ratio (aOR) 1.35, 95% confidence interval (CI) 1.07–1.71], moderate (aOR 1.26, 95% CI 1.06–1.49), high (aOR 1.45, 95% CI 1.08–1.95) and very high stress scores (aOR 1.56, 95% CI 1.03–2.37); very high anxiety score (aOR 1.45, 95% CI 1.13–1.86); and very high depression score (aOR 1.14, 95% CI 1.05–1.24) at 20 ± 1 weeks' gestation. Sensitivity analyses showed that very high anxiety and very high depression increases the risk of SGA in males but not in females whereas stress increases the risk of SGA in both males and females.ConclusionsThese findings suggest that prenatal stress, anxiety and depression measured at 20 weeks' gestation increase the risk of SGA. The effects of maternal anxiety and depression on SGA were strongest in male infants.
Outbreak of type A foodborne botulism at a boarding school, Uganda, 2008
Authors: VIRAY M. A. , WAMALA J. , FAGAN R. , LUQUEZ C. , MASLANKA S. , DOWNING R. , BIGGERSTAFF M. , MALIMBO M. , KIRENGA J. B. , NAKIBUUKA J. , DDUMBA E. , MBABAZI W. , SWERDLOW D. L. 
Published: February 2014

SUMMARYBotulism has rarely been reported in Africa. In October 2008, botulism was reported in three Ugandan boarding-school students. All were hospitalized and one died. A cohort study was performed to assess food exposures among students, and clinical specimens and available food samples were tested for botulinum toxin. Three case-patients were identified; a homemade, oil-based condiment was eaten by all three. In the cohort study, no foods were significantly associated with illness. Botulinum toxin type A was confirmed in clinical samples. This is the first confirmed outbreak of foodborne botulism in Uganda. A homemade, oil-based condiment was the probable source. Consumption of homemade oil-based condiments is widespread in Ugandan schools, putting children at risk. Clinicians and public health authorities in Uganda should consider botulism when clusters of acute flaccid paralysis are seen. Additionally, schools should be warned of the hazard of homemade oil-based condiments, and take steps to prevent their use.
Identification of Acoustically Similar and Dissimilar Vowels in Profoundly Deaf Adults Who Use Hearing Aids and/or Cochlear Implants: Some Preliminary Findings
Authors: Hay-McCutcheon Marcia J. , Peterson Nathaniel R. , Rosado Christian A. , Pisoni David B. 
Published: February 2014

Purpose
In this study, the authors examined the effects of aging and residual hearing on the identification of acoustically similar and dissimilar vowels in adults with postlingual deafness who use hearing aids (HAs) and/or cochlear implants (CIs).

Method
The authors used two groups of acoustically similar and dissimilar vowels to assess vowel identification. Also, the Consonant–Nucleus–Consonant Word Recognition Test (Peterson & Lehiste, 1962) and sentences from the Hearing in Noise Test (Nilsson, Soli, & Sullivan, 1994) were administered. Forty CI recipients with postlingual deafness (ages 31–81 years) participated in the study.

Results
Acoustically similar vowels were more difficult to identify than acoustically dissimilar vowels. With increasing age, performance deteriorated when identifying acoustically similar vowels. Vowel identification was also affected by the use of a contralateral HA and the degree of residual hearing prior to implantation. Moderate correlations were found between speech perception and vowel identification performance.

Conclusions

Identification performance was affected by the acoustic similarity of the vowels. Older adults experienced more difficulty identifying acoustically similar confusable vowels than did younger adults. The findings might lend support to the
ease of language understanding model
(Ronnberg, Rudner, Foo, & Lunner, 2008), which proposes that the quality and perceptual robustness of acoustic input affects speech perception.

Supplemental Material

https://doi.org/10.23641/asha.6170174
Frequency compensation circuit for adaptive on‐time control buck regulator
Authors: Shi Ling‐Feng , Xu Ling‐Yan 
Published: February 2014

A novel frequency compensation circuit for adaptive on‐time control buck regulator is presented in this study, which mainly applied to provide power supply for double data rate synchronous dynamic random access memory system. Typical ripple control regulator possesses the advantage of fast transient response and unconditional stability. However, it suffers significant steady‐state switching frequency variation when the input voltage and output voltage are varied. The on‐time is directly proportional to the output voltage and inversely proportional to the input voltage so that the regulator can dynamically adjust the turn‐on time of power switches according to the changes of input voltage and output voltage in steady‐state operation by adaptive on‐time control. Finally, an approximately fixed switching frequency is achieved. However, the variation of the switching frequency with load current still exists. Through the implementation of the frequency compensation circuit, the switching frequency variation caused by the load current variation can be effectively reduced in order to obtaining a more fixed switching frequency. The adaptive on‐time control regulator with frequency compensation has been successfully fabricated with 0.35 µm 30 V complementary double‐diffused metal oxide semiconductor process and full chip test results are provided to verify the proposed method in this study.
Incorporating post-translational modifications and unnatural amino acids into high-throughput modeling of protein structures
Authors: Nagata Ken , Randall Arlo , Baldi Pierre 
Published: February 2014

Motivation: Accurately predicting protein side-chain conformations is an important subproblem of the broader protein structure prediction problem. Several methods exist for generating fairly accurate models for moderate-size proteins in seconds or less. However, a major limitation of these methods is their inability to model post-translational modifications (PTMs) and unnatural amino acids. In natural living systems, the chemical groups added following translation are often critical for the function of the protein. In engineered systems, unnatural amino acids are incorporated into proteins to explore structure–function relationships and create novel proteins.
Results: We present a new version of SIDEpro to predict the side chains of proteins containing non-standard amino acids, including 15 of the most frequently observed PTMs in the Protein Data Bank and all types of phosphorylation. SIDEpro uses energy functions that are parameterized by neural networks trained from available data. For PTMs, the and accuracies are comparable with those obtained for the precursor amino acid, and so are the RMSD values for the atoms shared with the precursor amino acid. In addition, SIDEpro can accommodate any PTM or unnatural amino acid, thus providing a flexible prediction system for high-throughput modeling of proteins beyond the standard amino acids.
Availability and implementation: SIDEpro programs and Web server, rotamer libraries and data are available through the SCRATCH suite of protein structure predictors at http://scratch.proteomics.ics.uci.edu/
Contact: pfbaldi@uci.edu
Supplementary information: Supplementary Data are available at Bioinformatics online.
MGDB: crossing the marker genes of a user microarray with a database of public-microarrays marker genes
Authors: Huerta Mario , Munyi Marc , Expósito David , Querol Enric , Cedano Juan 
Published: February 2014

Summary: The microarrays performed by scientific teams grow exponentially. These microarray data could be useful for researchers around the world, but unfortunately they are underused. To fully exploit these data, it is necessary (i) to extract these data from a repository of the high-throughput gene expression data like Gene Expression Omnibus (GEO) and (ii) to make the data from different microarrays comparable with tools easy to use for scientists. We have developed these two solutions in our server, implementing a database of microarray marker genes (Marker Genes Data Base). This database contains the marker genes of all GEO microarray datasets and it is updated monthly with the new microarrays from GEO. Thus, researchers can see whether the marker genes of their microarray are marker genes in other microarrays in the database, expanding the analysis of their microarray to the rest of the public microarrays. This solution helps not only to corroborate the conclusions regarding a researcher's microarray but also to identify the phenotype of different subsets of individuals under investigation, to frame the results with microarray experiments from other species, pathologies or tissues, to search for drugs that promote the transition between the studied phenotypes, to detect undesirable side effects of the treatment applied, etc. Thus, the researcher can quickly add relevant information to his/her studies from all of the previous analyses performed in other studies as long as they have been deposited in public repositories.
Availability: Marker-gene database tool: http://ibb.uab.es/mgdb
Contact: jcedano@unorte.edu.uy
Optimization of gene set annotations via entropy minimization over variable clusters (EMVC)
Authors: Frost H. Robert , Moore Jason H. 
Published: February 2014

Motivation: Gene set enrichment has become a critical tool for interpreting the results of high-throughput genomic experiments. Inconsistent annotation quality and lack of annotation specificity, however, limit the statistical power of enrichment methods and make it difficult to replicate enrichment results across biologically similar datasets.Results: We propose a novel algorithm for optimizing gene set annotations to best match the structure of specific empirical data sources. Our proposed method, entropy minimization over variable clusters (EMVC), filters the annotations for each gene set to minimize a measure of entropy across disjoint gene clusters computed for a range of cluster sizes over multiple bootstrap resampled datasets. As shown using simulated gene sets with simulated data and Molecular Signatures Database collections with microarray gene expression data, the EMVC algorithm accurately filters annotations unrelated to the experimental outcome resulting in increased gene set enrichment power and better replication of enrichment results.Availability and implementation: http://cran.r-project.org/web/packages/EMVC/index.html.Contact: jason.h.moore@dartmouth.eduSupplementary information: Supplementary Data are available at Bioinformatics online.
Complex assessments or simple management procedures for efficient fisheries management: a comparative study
Authors: Geromont H. F. , Butterworth D. S. 
Published: February 2014

Abstract
Complex stock assessment methods are data- and expertise-hungry, with the annual updates of catch-at-age data and models typically seen as an essential requirement for sound management. But are the heavy commitments of resources required for this level of annual intervention really necessary to achieve efficient long-term fishery management? This question is addressed through a retrospective analysis of management performance over the last 20 years for four North Atlantic fish stocks. The assessments for two of these stocks have exhibited fairly strong retrospective patterns. The actual assessment advice for these stocks was provided based on complex assessment methods making use of age data. The outcomes are compared with what could have been achieved with much simpler catch control rules based upon age-aggregated survey indices alone. Even for the stocks whose assessments exhibit retrospective patterns, these simple rules can achieve virtually equivalent catch and risk performance, with much less interannual TAC variability, compared with what actually occurred over the past 20 years.