bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization and Stability Assessment of Monochamus alternatus Antimicrobial Peptide MaltAtt-1 in Komagataella phaffii GS115 for the Control of Pine Wood Nematode
Authors: Jiang Di , Xu Xuhuizi , Wang Zeguang , Yu Chao , Wang Zeqing , Xu Yuda , Chu Xu , Li Ming , Zhang Feiping , Hu Xia 
Published: August 2024

MaltAtt-1 is an antimicrobial peptide isolated from Monochamus alternatus with nematocidal activity against pine wood nematode. In this study, a eukaryotic expression system based on Komagataella phaffii GS115 was established, and its secretory expression of MaltAtt-1 was realized. The basic properties and secondary and tertiary structures of the antimicrobial peptide MaltAtt-1 were identified by bioinformatics analysis. MaltAtt-1 is a hydrophilic stable protein, mainly composed of an α-helix (Hh), β-folds (Ee), and irregular curls (Cc). The optimal fermentation conditions for MaltAtt-1 were determined by a single-factor test and the Box–Behnken response surface method, including an induction time of 72 h, induction temperature of 30 °C, culture medium of pH 7.6, methanol volume fraction of 2.0%, and an initial glycerol concentration of 1%. The stability of MaltAtt-1 indicated its resistant to UV irradiation and repeated freezing and thawing, but the antibacterial activity decreased significantly under the influence of high temperature and a strong acid and base, and it decreased significantly to 1.1 cm and 0.83 cm at pH 2.0 and pH 10.0, respectively. The corrected mortality of B. xylophilus achieved 71.94% in 3 h at a concentration of 300 mg·L−1 MaltAtt-1 exposure. The results provide a theoretical basis for the antimicrobial peptide MaltAtt-1 to become a new green and efficient nematicide.
Increased Homer Activity and NMJ Localization in the Vestibular Lesion het−/− Mouse soleus Muscle
Authors: Trautmann Gabor , Block Katharina , Gutsmann Martina , Besnard Stéphane , Furlan Sandra , Denise Pierre , Volpe Pompeo , Blottner Dieter , Salanova Michele 
Published: August 2024

We investigated the shuttling of Homer protein isoforms identified in soluble (cytosolic) vs. insoluble (membrane–cytoskeletal) fraction and Homer protein–protein interaction/activation in the deep postural calf soleus (SOL) and non-postural gastrocnemius (GAS) muscles of het−/− mice, i.e., mice with an autosomal recessive variant responsible for a vestibular disorder, in order to further elucidate a) the underlying mechanisms of disrupted vestibular system-derived modulation on skeletal muscle, and b) molecular signaling at respective neuromuscular synapses. Heterozygote mice muscles served as the control (CTR). An increase in Homer cross-linking capacity was present in the SOL muscle of het−/− mice as a compensatory mechanism for the altered vestibule system function. Indeed, in both fractions, different Homer immunoreactive bands were detectable, as were Homer monomers (~43–48 kDa), Homer dimers (~100 kDa), and several other Homer multimer bands (>150 kDA). The het−/− GAS particulate fraction showed no Homer dimers vs. SOL. The het−/− SOL soluble fraction showed a twofold increase (+117%, p ≤ 0.0004) in Homer dimers and multimers. Homer monomers were completely absent from the SOL independent of the animals studied, suggesting muscle-specific changes in Homer monomer vs. dimer expression in the postural SOL vs. the non-postural GAS muscles. A morphological assessment showed an increase (+14%, p ≤ 0.0001) in slow/type-I myofiber cross-sectional area in the SOL of het−/− vs. CTR mice. Homer subcellular immuno-localization at the neuromuscular junction (NMJ) showed an altered expression in the SOL of het−/−mice, whereas only not-significant changes were found for all Homer isoforms, as judged by RT-qPCR analysis. Thus, muscle-specific changes, myofiber properties, and neuromuscular signaling mechanisms share causal relationships, as highlighted by the variable subcellular Homer isoform expression at the instable NMJs of vestibular lesioned het−/− mice.
Remuneração Variável: uma estratégia motivacional nas organizações
Authors: Brito Ruth Januário Pereira 
Published: August 2024

Considerando que as empresas que procuram melhorar a remuneração dos seus colaboradores sem que isso tenha um impacto grave nas suas contas, uma opção extremamente viável é a implementação de um sistema de remuneração variável, adicional ao estipulado no contrato, que incentive e melhore a motivação e o comprometimento dos trabalhadores. Como facilitar a motivação dos funcionários da maneira mais eficaz, por meio da remuneração variável nas organizações? Objetiva-se investigar na literatura sobre remuneração variável e seus benefícios em termos de motivação organizacional. Para tanto, procede-se à revisão de literatura, por meio de consultas a livros, artigos e trabalhos acadêmicos, baseadas em definições científicas, tendo uma base confiável de informações. Desse modo, observa-se que cada vez mais empresas decidem implantar um sistema de remuneração baseado no desempenho, no âmbito da sua política remuneratória. Este sistema de remuneração variável liga o desempenho de cada trabalhador às metas da organização, às metas individuais que a empresa estabelece e a determinados resultados ou lucros alcançados, o que permite concluir que embora pareça que a remuneração variável só tem pontos positivos, a sua falta de regulamentação e o fato de poder ser deixada ao livre arbítrio de apenas uma das partes pode resultar em alguns problemas para a empresa. Na verdade, há várias questões a ter em conta quando se bplaneja implementar um sistema de remuneração variável; portanto, é importante obter um bom aconselhamento preventivo e corretivo em questões trabalhistas.
KELEKATAN IBU MEMBENTUK KEYAKINAN YANG KUAT TERHADAP ATURAN: ANALISIS MODEL KONTROL SOSIAL PERILAKU REMAJA BERISIKO PENYALAHGUNA NAPZA
Authors: Purwandari Eny , Lestari Rini 
Published: August 2024

ABSTRAKPerilaku penyalahgunaan NAPZA sebagai bentuk penyimpangan perilaku yang harus dikontrol agar tidak terjadi peningkatan penyalahgunaan dan kerugian di berbagai sektor kehidupan, baik ekonomi, kesehatan, sosial, maupun individu yang bersangkutan. Keluarga sebagai salah satu lembaga kontrol sosial mempunyai pengaruh yang kuat terhadap munculnya perilaku penyalahgunaan NAPZA. Teori kontrol sosial akan mengkaji fungsi keluarga, khususnya ibu dalam membentuk keyakinan terhadap aturan pada kasus penyalahgunaan NAPZA. Subjek penelitian ini adalah remaja yang menunjukkan risiko penyalahgunaan NAPZA sebanyak 241 remaja (usia 15-17 tahun) dengan cluster random sampling dengan kriteria inklusif harus tinggal Bersama kedua orang tua. Data dianalisis dengan menggunakan structural equation model (SEM) dengan indikator indeks kecocokan model GFI = 0,925; CFI=908; AGFI=0,879; TLI=0,874; estimasi kelekatan ibu-anak terhadap keyakinan aturan sebesar 0,41, dan estasi keyakinan aturan terhadap risiko penyalahgunaan napza sebesar -0,35. Hasil menunjukkan bahwa kelekatan ibu-anak lebih berperan dibandingkan kelekatan ayah dalam membentuk keyakinan terhadap aturan seorang remaja sehingga mampu mengurangi risiko penyalahgunaan NAPZA. Implikasinya peran ibu dapat lebih ditingkatkan dalam pengasuhan agar mampu memberikan rasa nyaman pada anak dengan pengetahuan dan ketrampilannya, sehingga transmisi nilai, aturan terinternalisasi pada diri anak.ABSTRACTDrug abuse behavior is a kind of behavioral deviance that needs to be managed in order to prevent abuse and losses in the social, health, economic, and individual domains of life from increasing. The establishment of drug misuse behavior is significantly influenced by the family as a social control institution. According to social control theory, the role of the mother in particular in setting family norms about drug misuse will be investigated. Cluster random selection was used to choose 241 teens (15–17 years old) who met the inclusionary criterion of having to live with both parents and shown a risk of drug misuse. A structural equation model (SEM) was used to evaluate the data. The model fit index indicator was GFI = 0.925; CFI = 908; AGFI = 0.879; TLI = 0.874. The estimate of rule beliefs' relationship to the likelihood of drug abuse was -0.35, and the estimate of mother-child attachment to rule beliefs was 0.41. The findings indicate that, in order to lower the likelihood of drug usage, a teen's attitudes about regulations are formed more by their mother and child than by their father. The inference is that the mother's role in raising her child can be further developed so that she can use her knowledge and abilities to comfort the child and help the youngster internalize the rules and values that have been imparted to them.
DERMATOSCOPIA: UNA HERRAMIENTA INDISPENSABLE EN EL DIAGNÓSTICO DERMATOLÓGICO.
Authors: Loor Judith Narcisa Cabrera , Masterrena Aidee Godiva Pinoargote , Vera María Fernanda Palacios , Menoscal Cristóbal Lenin Fajardo , Intriago Israel Andrés Bermudez , Quiñonez Diana Karina López , Cisneros Loreley Vanessa Calvas , Zambrano Nicole Lissette Vásquez , Rivera Laura Stefany Barrera , A Evelin Zulime Asencio De La , Guaraca Ruth Eulalia Maita , Calderón Fernando Alexander Bravo 
Published: August 2024

La dermatoscopia, también conocida como epiluminescencia o dermatoscopía, ha revolucionado el diagnóstico dermatológico al permitir una visualización detallada de las lesiones cutáneas. Objetivo: Este artículo revisa la relevancia y utilidad de la dermatoscopia en el diagnóstico de enfermedades de la piel, explorando avances tecnológicos recientes. Metodología: Se realizó una búsqueda exhaustiva en bases de datos especializadas y se seleccionaron artículos y revisiones relevantes publicados desde 2018. Resultados: Los resultados muestran que la dermatoscopia mejora la precisión diagnóstica de enfermedades como el melanoma, carcinoma basocelular y espinocelular, así como el liquen plano y la psoriasis. Los avances tecnológicos, como la dermatoscopia digital y la epiluminescencia polarizada, han mejorado la calidad de las imágenes y la capacidad de seguimiento de lesiones. A pesar de las ventajas de cada tipo de dermatoscopia, también existen limitaciones, como la necesidad de equipo especializado y la dificultad en áreas con pelo o lesiones exudativas. Conclusiónes: La dermatoscopia es una herramienta invaluable en la práctica clínica dermatológica, mejorando la precisión diagnóstica y el manejo de las enfermedades de la piel. Los avances tecnológicos en la dermatoscopia han ampliado su utilidad, pero es importante tener en cuenta las consideraciones prácticas y las limitaciones de cada tipo de dermatoscopia en su uso clínico.
TERAPIAS NEUROPROTECTORAS Y FÁRMACOS EMERGENTES EN EL TRATAMIENTO DEL ICTUS: AVANCES RECIENTES.
Authors: Menoscal Cristóbal Lenin Fajardo , Intriago Israel Andrés Bermudez , Quiñonez Diana Karina López , Cisneros Loreley Vanessa Calvas , Zambrano Nicole Lissette Vásquez , Rivera Laura Stefany Barrera , A Evelin Zulime Asencio De La , Calderón Fernando Alexander Bravo , Honores Félix Jossue Solano , Nieto Kristy Madelaine Arriciaga , Siguencia Ronald Jonathan Cañarte , Antepara Bismarck Stiven Pazmiño 
Published: August 2024

El ictus, también llamado accidente cerebrovascular (ACV), es una afección cerebrovascular aguda que interrumpe el flujo sanguíneo al cerebro, lo que conduce a daños neuronales y disfunción cerebrall, siendo una de las principales causas de discapacidad y mortalidad a nivel mundial. A pesar de los esfuerzos en prevención y tratamiento, sigue siendo un desafío médico debido a la falta de terapias efectivas y seguras. Objetivo: Analizar avances recientes en terapias neuroprotectoras y fármacos emergentes para el ictus. Metodología: Se realizó una búsqueda exhaustiva en bases de datos como PubMed, Scopus y Google Académico. Se seleccionaron estudios publicados en inglés y español desde 2018 hasta la fecha actual, incluyendo revisiones sistemáticas, metaanálisis, ensayos clínicos y estudios observacionales relevantes. Resultados: Se destacan varios fármacos y productos naturales con potencial terapéutico para el tratamiento del ictus. Por ejemplo, la quercetina ha mostrado efectos beneficiosos en modelos animales de isquemia cerebral, reduciendo la permeabilidad de la barrera hematoencefálica y mejorando la función neurológica. Otros compuestos como la vinpocetina, el SY-007, y el Protopanaxatriol (PPT) también muestran promesas, aunque se necesitan más investigaciones clínicas para confirmar su eficacia y seguridad. Los productos naturales como la puerarina, la pinocembrina, el EGCG y el resveratrol han demostrado propiedades antioxidantes, antiinflamatorias y neuroprotectoras, mostrando efectos positivos en la reducción del daño cerebral isquémico y la mejora de la función neurológica en modelos animales. Conclusiónes: Los avances en terapias neuroprotectoras y fármacos emergentes para el tratamiento del ictus son prometedores, pero se necesita más investigación para traducir estos hallazgos en beneficios clínicos tangibles para los pacientes.
Peningkatan Hasil Belajar Siswa tentang Gerak Lurus dengan Menerapkan Model NHT di Kelas X MIPA 1 SMAN 2 Solok
Authors: Susanti Rosi 
Published: August 2024

This research aims to increase the student’s learning achievement about straight movement by applying NHT model at grade X of natural. Science class I Physics is one of the subjects that is not interesting to some of the student of SMAN 2 Solok. Because it is considered as a difficult subject, so that they tend to be passive to join the physics class. One of the models to increase the student activeness is NHT model. This research is an action research by having collaboration between the researcher and the researcher and the physics teacher. The subject research are 36 student of SMAN 2 Solok,grade X of natural science class I In year of 2021/2022. The technique of data collection uses student’s activities observation space and student’s test marks. The result show that by applying NHT model at the material of straight movement at grade x of natural science I at SMA 2 Solok. There is increase to: (1). The student’s activities at cycle I that is 72,9%, then at the cycle 2 it become 95 %, the percentage increasing is 22,9%.(2).Teacher’s activeness at the first meeting is 73,07% and getting increases to the forth meeting to 90,74%. It increases 17,67% with the very good predicate, and (3).The student learning achievement, at the cycle 2 there are 5 students (14%) got very good score, 25 students(69,5%) got good score, 5 students(14%) got middle score, and there is only I student(24,77 %) got the lowest score.
Implementasi Sistem Informasi Akuntansi Kredit Gadai Emas Di PT Pegadaian
Authors: Meilinda Yesica , Triandi Triandi , Pramiudi Udi 
Published: August 2024

This research was prepared to determine the procedures for granting, repaying, and auctioning gold pawn loans at PT Pegadaian (Persero) Tajur Branch Service Unit as one of the Fast and Secure Credit products offered by the company to the public to be able to obtain loans with collateral in the form of gold. The purpose of this writing is to find out about the Gold Pawn Credit Accounting Information System at PT Pegadaian and how the effectiveness of Internal Control on the Gold Pawn Information System at PT Pegadaian. The procedure for granting a gold pawn starts from a credit application, valuation of collateral, disbursement of credit loan funds, to storage of collateral, followed by settlement of the loan money within a maximum of four months by redemption, installments, or renewal. If the customer is unable to repay later, the collateral will be auctioned with the customer's consent based on the terms and conditions at the beginning of the credit loan process. Based on the results of the review, all of the above procedures have been carried out by the principles of good internal control, including standard procedures that are outlined in the form of flowcharts, there is a separation of duties made in the organizational structure and job descriptions, there are appraisers to overcome the risk of the insufficient value of collateral, there are adequate authorization procedures when granting credit and the auction process, there is verification of credit granting requirements, security of pawn deposits is very adequate, supported by a pawn application system and supporting documents to ensure the achievement of the objectives of granting credit with gold pawning.

Keywords: Gold Pawn Credit Procedure, Internal Control, Accounting Information System
Implementasi Saluran Distribusi Pada PT Surya Donasin
Authors: Ramdani Muhamad Ridwan , Nurendah Yulia , Sulistiono Sulistiono 
Published: August 2024

Distribution channels play a very important role in the success of a company's marketing. because distribution is the spearhead of the company in marketing products or services. Products reach consumers directly or indirectly through distribution channels. In choosing the most appropriate distribution channel to use, the company must be in accordance with the conditions and objectives of the company. Distribution channels are the core of the company's efforts to distribute goods from producers to consumers. The author's purpose of this study is to find out: 1) Implementation of distribution channels at PT Surya Donasin, 2) What are the obstacles to implementing distribution channels at PT Surya Donasin, 3) Efforts to deal with obstacles to implementing distribution channels at PT Surya Donasin. The results of the review conducted, 1) The distribution channel carried out by PT Surya Donasin uses an intensive distribution channel to obtain a wider market. 2) Constraints in implementing distribution channels, namely, market potential that has not been covered, payment administration that does not match the specified time, lack of human resources and facilities to support the distribution process, procurement of goods that are often out of stock. 3) Efforts to overcome obstacles, namely, the Supervisor makes visits to check each store, checks stores that still have bills that are past the payment time, adds resources and facilities as needed, always maintains inventory so that out of stock does not occur

Keywords: distribution channels, implementation, marketing
Impact The Covid 19 Pandemic on the Tourism Business Stakeholders Performance in Bogor City
Authors: Marpaung Annaria Magdalena , Hadi Cecilia Valentina Sri , Marpaung Bintang Sahala 
Published: August 2024

Pandemic and Tourism Business Performance

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Submitted:
MAY 2024

Accepted:
JULY 2024

This study done with objective For know How impact covid 19 pandemic against performance of the perpetrators business restaurants and hotels . Deep sample this study are the perpetrators business restaurant and hotel located in the city of Bogor . Data collection was carried out with do interview direct with perpetrator business . Research result show application Policy Health Protocols in sectors tourist give impact positive form obedience public . Ownership CHSE certificate , provide impact positive on the entity industry supporter tourist Hotel and Destination category Tourism , and not give influence significant in the Restaurant category

Keywords: Covid 19 pandemic , activities business , CHSE.
A Semiotic Analysis of Nonverbal Linguistic Signals Used On Billboard Posters as a Means of Creating Public Awareness During the Covid-19 Pandemic in Douala
Authors: Fuh Ngonjo Victor 
Published: August 2024

This paper examines the use of nonverbal linguistic signals on billboard posters during the Covid-19 pandemic in Douala. It has been noticed that nonverbal signals such as sweating, wearing a nose mask, washing of hands with clean running water and soap and standing two metres apart from each other and the use of colours such as white and red among others play an important role in the way human beings communicate especially during a period of crisis. Although it is nonverbal, this means of communication acts more than the verbal one. This work focuses on nonverbal linguistic features used on billboard posters in the city of Douala as a means of creating public awareness in relation to the Covid-19 pandemic so that the contamination and mortality rate can be reduced. This study is of great value because it demonstrates how people should live during a pandemic era without being contaminated. This research uses a qualitative research design. The researcher culled some pictures that were pasted on billboards during the crisis (2020-2021) on the streets of Douala. Insight was drawn from Barthes (1964) theory of semiotics. The findings indicated that people washed their hands with clean running water and soap, they wore masks, arrows were used to show how people should stand with others in public, colours such as red was used to show how dangerous this virus is and the white colour was also used to indicate that people need to be clean during this period so that they can minimise the chances of being contaminated. Capitalisation was used either in red or black to attract the attention of the public to the messages written on the billboards. The researcher concludes that people should develop the culture of reading public notices especially billboard posters during epidemics and pandemics so that they can save their lives.
26 février 1942 une rafle d’otages à Dijon et à Chalon-sur-Saône : un événement oublié
Authors: Vouzelle Dimitri 
Published: August 2024

Le 26 février 1942, treize hommes juifs sont arrêtés dans la région de Dijon. Il s’agit de la seule rafle d’otages à Dijon durant l’Occupation. À partir d’archives publiques et privées, cet article analyse le contexte de ces arrestations, le choix des otages, le devenir des hommes arrêtés et pourquoi cet événement est demeuré inconnu jusqu’à ce jour.
Les « Dimettes » de Saône-et-Loire, entre insubordination et désindustrialisation (1954 au très contemporain)
Authors: Castellesi Romain 
Published: August 2024

Cet article entend questionner la résistance des ouvrières de l’entreprise de sous-vêtements Dim, située dans le département de Saône-et-Loire, au phénomène de désindustrialisation, pendant le second vingtième siècle. Précocement implantée, au milieu des années 1950, l’entreprise compte jusqu’à sept usines au début des années 1970, réparties du Bourbonnais à la Bresse bourguignonne. L’entrée précoce en récession du secteur bouleverse la formation d’une génération d’ouvrières, dont les traces subsistent encore aujourd’hui dans le seul site ayant survécu au démantèlement, à Autun. Entre ces deux dates, ces « invisibles parmi les invisibles », ouvrières souvent issues d’un milieu rural, ayant rejoint tardivement la condition usinière, donnent à voir les métamorphoses de l’action ouvrière au prisme du genre et en situation de crise économique. Ces ouvrières, à l’histoire méconnue, oscillent entre insubordination et démobilisation.