bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interference of ATP‐Adenosine Axis by Engineered Biohybrid for Amplifying Immunogenic Cell Death‐Mediated Antitumor Immunotherapy
Authors: Deng Xin‐Chen , Liang Jun‐Long , Zhang Shi‐Man , Wang Yu‐Zhang , Lin Yan‐Tong , Meng Ran , Wang Jia‐Wei , Feng Jun , Chen Wei‐Hai , Zhang Xian‐Zheng 
Published: July 2024

AbstractImmunogenic cell death (ICD) often results in the production and accumulation of adenosine (ADO), a byproduct that negatively impacts the therapeutic effect as well as facilitates tumor development and metastasis. Here, an innovative strategy is elaborately developed to effectively activate ICD while avoiding the generation of immunosuppressive adenosine. Specifically, ZIF‐90, an ATP‐responsive consumer, is synthesized as the core carrier to encapsulate AB680 (CD73 inhibitor) and then coated with an iron‐polyphenol layer to prepare the ICD inducer (AZTF), which is further grafted onto prebiotic bacteria via the esterification reaction to obtain the engineered biohybrid (Bc@AZTF). Particularly, the designed Bc@AZTF can actively enrich in tumor sites and respond to the acidic tumor microenvironment to offload AZTF nanoparticles, which can consume intracellular ATP (iATP) content and simultaneously inhibit the ATP‐adenosine axis to reduce the accumulation of adenosine, thereby alleviating adenosine‐mediated immunosuppression and strikingly amplifying ICD effect. Importantly, the synergy of anti‐PD‐1 (αPD‐1) with Bc@AZTF not only establishes a collaborative antitumor immune network to potentiate effective tumoricidal immunity but also activates long‐lasting immune memory effects to manage tumor recurrence and rechallenge, presenting a new paradigm for ICD treatment combined with adenosine metabolism.
Molten Salt Derived MXenes: Synthesis and Applications
Authors: Kruger Dawid D. , García Hermenegildo , Primo Ana 
Published: July 2024

AbstractAbout one decade after the first report on MXenes, these 2D early transition metal carbides or nitrides have become among the best‐performing materials in electrode applications related to electrical energy storage devices and power‐to‐fuels conversion. MXenes are obtained by a top‐down approach starting from the appropriate 3D MAX phase that undergoes etching of the A‐site metal. Initial etching procedures are based on the use of concentrated HF or the in situ generation of this highly corrosive and poisonous reagent. Etching of the MAX phase is one of the major hurdles limiting the progress of the field. The present review summarizes an alternative, universal, and easily scalable etching procedure based on treating the MAX precursor with a Lewis acid molten salt. The review starts with presenting the current state of the art of the molten salt etching procedure to obtain or modify MXene, followed by a summary of the applications of these MXene samples. The aim of the review is to show the versatility and advantages of molten salt etching in terms of general applicability, control of the surface terminal groups, and uniform deposition of metal nanoparticles, among other features of the procedure.
Limiting Resources Define the Global Pattern of Soil Microbial Carbon Use Efficiency
Authors: Cui Yongxing , Hu Junxi , Peng Shushi , Delgado‐Baquerizo Manuel , Moorhead Daryl L. , Sinsabaugh Robert L. , Xu Xiaofeng , Geyer Kevin M. , Fang Linchuan , Smith Pete , Peñuelas Josep , Kuzyakov Yakov , Chen Ji 
Published: July 2024

AbstractMicrobial carbon (C) use efficiency (CUE) delineates the proportion of organic C used by microorganisms for anabolism and ultimately influences the amount of C sequestered in soils. However, the key factors controlling CUE remain enigmatic, leading to considerable uncertainty in understanding soil C retention and predicting its responses to global change factors. Here, we investigate the global patterns of CUE estimate by stoichiometric modeling in surface soils of natural ecosystems, and examine its associations with temperature, precipitation, plant‐derived C and soil nutrient availability. We found that CUE is determined by the most limiting resource among these four basic environmental resources within specific climate zones (i.e., tropical, temperate, arid, and cold zones). Higher CUE is common in arid and cold zones and corresponds to limitations in temperature, water, and plant‐derived C input, while lower CUE is observed in tropical and temperate zones with widespread limitation of nutrients (e.g., nitrogen or phosphorus) in soil. The contrasting resource limitations among climate zones led to an apparent increase in CUE with increasing latitude. The resource‐specific dependence of CUE implies that soils in high latitudes with arid and cold environments may retain less organic C in the future, as warming and increased precipitation can reduce CUE. In contrast, oligotrophic soils in low latitudes may increase organic C retention, as CUE could be increased with concurrent anthropogenic nutrient inputs. The findings underscore the importance of resource limitations for CUE and suggest asymmetric responses of organic C retention in soils across latitudes to global change factors.
Challenging colonial logics of habit in Australiaʼs economic statecraft with Pacific Islands
Authors: Koro Maima , McNeill Henrietta 
Published: July 2024

AbstractWhen Australia deploys tools of statecraft in attempts to develop influence with Pacific Island neighbours, inherent colonial legacies exist which are not always recognised, but ultimately affect relationships. We examine Australian economic tools of statecraft applied to migration, trade and development aid, and how a colonial ‘logic of habit’ persists within their deployment which unintentionally undermines their effectiveness. In highlighting these historical hangovers, we suggest reimagining Australiaʼs perceptions of and relations with the Pacific—from neighbours with resources to be utilised, to mutually respected trading partners.
Hofmeister Effect Mediated Conductivity of Hydrogel Electrolytes for High Performance Supercapacitor
Authors: Lv Bingxi , Guo Qingqing , Ji Xingxiang , Gai Ligang , Liu Libin 
Published: July 2024

AbstractRegulating the performance of hydrogel electrolytes by Hofmeister effect has attracted great interest. However, the Hofmeister effects of cations on the conductivity of hydrogel electrolytes are rarely reported. Here, hydrogel electrolytes (polySA) have been fabricated by random copolymerization of zwitterionic monomers in the presence of NH4Cl, NaCl and LiCl. The weak interaction between NH4+ with water and molecular chains makes polySA‐NH4+ electrolyte have high conductivity at room temperatures, whereas the strong interaction between Li+ with water and molecular chains makes polySA‐Li+ electrolyte possess good anti‐freezing properties and high mechanical strength. The polySA‐Li+ hydrogel electrolyte can have a conductivity of 9.63 mS cm−1 at −35 °C. Supercapacitors assembled with polySA‐Li+ offers high specific capacitance of 52.25 F g−1 at 25 °C and 47.75 F g−1 at −35 °C. The capacitance retention is 94.64 % after 10 days at −35 °C. Our work shows that different properties of hydrogel electrolytes can be achieved by regulating Hofmeister effect, which provides a new way to prepare high‐performance energy storage materials.
Cyberbullying and fanatic behaviours of football fans in Turkey: The role of dark personality traits, team loyalty and demographics
Authors: Simsek Eylem , Ozturk Mehmet Berk 
Published: July 2024

AbstractThis study explores the cyberbullying behaviour of football fans in Turkey, examining the effects of fanaticism, dark personality traits, demographic factors and team loyalty. The research encompasses a sample of 152 individuals, revealing that marital status significantly influences both cyberbullying and fanaticism. Various factors, such as how fans watch matches, involvement in fan associations, the purpose of social media use, and attendance at amateur matches, contribute significantly to variations in cyberbullying levels. Fanaticism and dark personality traits are positively correlated with cyberbullying. Regression analyses reveal that the purpose of social media use and watching amateur matches account for 9.3% of cyberbullying, while violence (42.9%) and psychopathy (5.2%) explained 48.2% of the total variance in cyberbullying. Concerning team loyalty, factors like match‐watching habits, attendance at amateur matches, social media use intentions, preferred teams, match‐watching frequency and location of match‐watching jointly account for 41% of the total variance in fanaticism. Additionally, cyberbullying (27.2%) and Machiavellianism (6.3%) together accounted for a total of 33.5% of the variance explained in fanaticism. These findings offer valuable insights into the complex dynamics of cyberbullying and fanaticism within the context of football fandom in Turkey, providing a foundation for future research and potential interventions in this area.
Impact of application volume and spray droplet size on soybean harvest aid efficacy
Authors: McNeal Jacob P. , Dodds Darrin M. , Catchot Angus L. , Gore Jeffrey , Irby Jon Trenton , Kruger Greg R. 
Published: July 2024

AbstractThroughout the mid‐southern United States, indeterminate maturity group (MG) IV soybean (Glycine max L. Merr.) have largely taken the place of determinate MG V and VI soybean in order maximize yield. However, this shift towards earlier maturity groups results in more green plant material at physiological maturity. Consequently, harvest aids are of interest to producers who seek to defoliate and desiccate soybean in a timely and uniform manner. Field experiments were conducted from 2019 to 2020 to evaluate the impact of harvest aid, application volume, and spray droplet volume mean diameter (VMD) on soybean harvest aid efficacy in Mississippi. Applications of paraquat, saflufenacil, and sodium chlorate were made when soybean averaged 65% brown pods, with application volumes of 5 and 20 gal. acre−1, and VMDs of 200, 500, and 800 µm. Defoliation, desiccation, and green stems were evaluated at 3, 7, 10, and 14 days after treatment (DAT). Soybean grain yield was obtained at harvest and adjusted to 13% moisture. Harvest aid efficacy did not vary due to application volume. Spray droplet spectra with a VMD of 200 µm maximized both defoliation and desiccation efficacy. At 14 DAT, applications of paraquat and sodium chlorate resulted in 95% defoliation but were similar to saflufenacil at 89%. Applications of paraquat resulted in desiccation of 16 more percentage points than saflufenacil, and 8 more percentage points than sodium chlorate. These data indicate soybean harvest aid applications should contain paraquat. Although efficacy was maximized with spray droplet spectra with a VMD of 200 µm, the total variance in efficacy due to VMD of spray droplets was minimal.
Synthesis and Reactivity of Masked Organic Sulfates
Authors: Kumar Villuri Bharath , Desai Umesh R. 
Published: July 2024

AbstractNature offers a variety of structurally unique, sulfated endobiotics including sulfated glycosaminoglycans, sulfated tyrosine peptides, sulfated steroids/bile acids/catecholamines. Sulfated molecules display a large number of biological activities including antithrombotic, antimicrobial, anticancer, anti‐inflammatory, and others, which arise from modulation of intracellular signaling and enhanced in vivo retention of certain hormones. These characteristics position sulfated molecules very favorably as drug‐like agents. However, few have reached the clinic. Major hurdles exist in realizing sulfated molecules as drugs. This state‐of‐the‐art has been transformed through recent works on the development of sulfate masking technologies for both alkyl (sulfated carbohydrates, sulfated steroids) and aryl (sTyr‐bearing peptides/proteins, sulfated flavonoids) sulfates. This review compiles the literature on different strategies implemented for different types of sulfate groups. Starting from early efforts in protection of sulfate groups to the design of newer SuFEx, trichloroethyl, and gem‐dimethyl‐based protection technologies, this review presents the evolution and application of concepts in realizing highly diverse, sulfated molecules as candidate drugs and/or prodrugs. Overall, the newer strategies for sulfate masking and demasking are likely to greatly enhance the design and development of sulfated molecules as non‐toxic drugs of the future.
Role of WAVE3 as an actin binding protein in the pathology of triple negative breast cancer
Authors: Master Kruyanshi , El Khalki Lamyae , Bayachou Mekki , Sossey‐Alaoui Khalid 
Published: July 2024

AbstractBreast cancer, a prevalent global health concern, has sparked extensive research efforts, particularly focusing on triple negative breast cancer (TNBC), a subtype lacking estrogen receptor (ER), progesterone receptor, and epidermal growth factor receptor. TNBC's aggressive nature and resistance to hormone‐based therapies heightens the risk of tumor progression and recurrence. Actin‐binding proteins, specifically WAVE3 from the Wiskott–Aldrich syndrome protein (WASP) family, have emerged as major drivers in understanding TNBC biology. This review delves into the intricate molecular makeup of TNBC, shedding light on actin's fundamental role in cellular processes. Actin, a structural element in the cytoskeleton, regulates various cellular pathways essential for homeostasis. Its dynamic nature enables functions such as cell migration, motility, intracellular transport, cell division, and signal transduction. Actin‐binding proteins, including WAVE3, play pivotal roles in these processes. WAVE3, a member of the WASP family, remains the focus of this review due to its potential involvement in TNBC progression. While actin‐binding proteins are studied for their roles in healthy cellular cycles, their significance in TNBC remains underexplored. This review aims to discuss WAVE3's impact on TNBC, exploring its molecular makeup, functions, and significance in tumor progression. The intricate structure of WAVE3, featuring elements like the verprolin–cofilin–acidic domain and regulatory elements, plays a crucial role in regulating actin dynamics. Dysregulation of WAVE3 in TNBC has been linked to enhanced cell migration, invasion, extracellular matrix remodeling, epithelial‐mesenchymal transition, tumor proliferation, and therapeutic resistance. Understanding the role of actin‐binding proteins in cancer biology has potential clinical implications, making them potential prognostic biomarkers and promising therapeutic targets. The review emphasizes the need for further research into actin‐binding proteins' clinical applications, diagnostic value, and therapeutic interventions. In conclusion, this comprehensive review explores the complex interplay between actin and actin‐binding proteins, with special emphasis on WAVE3, in the context of TNBC. By unraveling the molecular intricacies, structural characteristics, and functional significance, the review paves the way for future research directions, clinical applications, and potential therapeutic strategies in the challenging landscape of TNBC.
Antibacterial and oral tissue effectiveness of a mouthwash with a novel active system of amine + zinc lactate + fluoride
Authors: Schaeffer Lyndsay M. , Yang Ying , Daep Carlo , Makwana Ekta , Isapour Golnaz , Huber Norbert 
Published: July 2024

AbstractObjectivesReflecting the need for an effective support for the daily oral hygiene routine of patients experiencing (symptoms of) gum inflammation, a new mouthwash has been developed containing an amine + zinc lactate + fluoride system. The in vitro efficacy of this product was assessed using traditional laboratory methods, as well as novel experimentation.Materials and MethodsThis mouthwash has been evaluated in a series of laboratory tests including two short interval kill tests (SIKTs), a 12‐h (longer term) biofilm regrowth assay, a plaque glycolysis assay, and an aerobic, repeated exposure biofilm model, as well as tests for soft tissue uptake and LPS neutralization.ResultsSeveral laboratory studies demonstrate that a mouthwash containing an amine + zinc lactate + fluoride system provides short‐term and long‐term antibacterial activity. While the immediate efficacy of this formula has been shown to be driven by the presence of the amine, zinc lactate provides a long‐term antibacterial effect, as well as is able to inhibit bacterial metabolism.ConclusionsThis research provides the basis for understanding the mode of action of this new mouthwash formulation and explains the previously observed clinical efficacy of this formula against plaque and gingivitis.
Diversity and distribution of bamboo‐feeding true bugs in China
Authors: Jiang Kun , Chen Juhong , Wang Shujing , Li Yanfei , Zhang Danli , Hu Haoyuan , Bu Wenjun 
Published: July 2024

AbstractThe Bambusoideae subfamily, originating in the late Cretaceous, has evolved to include over 1500 species globally. Notably, China hosts the richest diversity of Bambusoideae, with 728 species documented. After a long period of coevolution, plenty of animals could feed on these plants rich in cellulose and lignin. As an important group of pests and participants in the ecosystem, bamboo‐feeding true bugs (BFTBs, or bamboo‐feeding Heteropteran insects) have attracted the attention of researchers. However, the diversity and distribution of BFTBs still lack systematic and generalized research. In this study, we reviewed the BFTBs in China and simulated the diversity pattern and the driving forces of this pattern. A list of 36 genera with 69 species of BFTBs in China was obtained through paper review and field surveys. And their bamboo‐feeding habit had multiple independent origins. The spatial diversity pattern showed that the biodiversity hotspots of BFTBs are located in and around the tropics of southern China. Environmental driving force analysis showed that the minimum temperature of coldest month and annual precipitation were the dominant environmental factors shaping the spatial diversity of BFTBs. Our work quantified the diversity and distribution of BFTBs in China, providing fundamental data support for pest control and evolutionary research.
Oviposition strategies in Pieridae butterflies and the role of an egg‐killing plant trait therein
Authors: Peters Dorette H. , Greenberg Liana O. , Fatouros Nina E. 
Published: July 2024

AbstractMost herbivorous insects are host‐plant specialists that evolved detoxification mechanisms to overcome their host plant's toxins. In the evolutionary arms‐races between Pieridae butterflies and Brassicaceae plants, some plant species have evolved another defence against the pierids: egg‐killing. Underneath the eggs, leaves develop a so‐called hypersensitive response (HR)‐like cell death. Whether some butterflies have evolved oviposition strategies to counter‐adapt against egg‐killing remains to be studied. In this study, we assessed the oviposition site location of Pieridae butterflies on their natural host plants. We described the plant tissue on which we located the eggs of the most common Pieridae in the Netherlands: Gonepteryx rhamni, Anthocharis cardamines, Pieris rapae, P. napi, P. brassicae and P. mannii. Additionally, we assessed expression of HR‐like cell death in response to the deposited butterfly eggs. We found that both A. cardamines and G. rhamni mainly oviposited on the floral stem and the branch, respectively, and oviposited on host plants from lineages not expected to kill pierid eggs. Accordingly, no HR‐like cell death was seen. All Pieris eggs found were located on leaves of their host, the only tissue found to express HR‐like cell death. Furthermore, each Pieris species was found to at least occasionally oviposit on Brassica nigra. This was the only plant species in this survey that expressed HR‐like cell death in response to the eggs of P. rapae, P. napi and P. brassicae. Our observations demonstrate that HR‐like cell death remains an effective defence strategy against these Pieris species and as such did not find evidence for the hypothesized counterstrategies. Surveying certain key species and disentangling the micro‐evolution of oviposition strategies within a species would allow us to further investigate potential counter‐adaptations that evolved against HR‐like cell death. This study provides the basis for further investigation of potential counter‐adaptations to egg‐killing defences.
The optimized Maxent model reveals the pattern of distribution and changes in the suitable cultivation areas for Reaumuria songarica being driven by climate change
Authors: Wang Xinyou , Li Zhengsheng , Zhang Lijun , Wang Yanlong , Liu Ying , Ma Yushou 
Published: July 2024

AbstractReaumuria songarica, a drought‐resistant shrub, is widely distributed and plays a crucial role in the northern deserts of China. It is a key species for desert rehabilitation and afforestation efforts. Using the Maxent model to predict suitable planting areas for R. songarica is an important strategy for combating desertification. With 184 occurrence points of R. songarica and 13 environmental variables, the optimized Maxent model has identified the main limiting factors for its distribution. Distribution patterns and variation trends of R. songarica were projected for current and future climates (2030s, 2050s, 2070s, and 2090s) and different scenarios (ssp_126, ssp_370, and ssp_585). Results show that setting parameters to RM (regulation multiplier) = 4 and FC (feature combination) = LQHPT yields a model with good accuracy and high reliability. Currently, R. songarica is primarily suitable for desert control in eight provinces and autonomous regions, including Inner Mongolia, Xinjiang, Qinghai, and Ningxia. The total suitable planting area is 148.80 × 104 km2, representing 15.45% of China's land area. Precipitation (Precipitation of the wettest month, Precipitation of the warmest quarter, and Annual precipitation) and Ultraviolet‐B seasonality are the primary environmental factors limiting the growth and distribution of R. songarica. Mean temperature of the warmest quarter is the primary factor driving changes in the distribution of suitable areas for R. songarica under future climate scenarios. In future climate scenarios, the suitable planting area of R. songarica will shrink, and the distribution center will shift towards higher latitude, potentially indicate further desertification. The area of highly suitable habitat has increased, while moderately and less suitable habitat areas have decreased. Increased precipitation within R. songarica's water tolerance range is favorable for its growth and reproduction. With changes in the suitable cultivation area for R. songarica, priority should be given to exploring and utilizing its germplasm resources. Introduction and cultivation can be conducted in expanding regions, while scientifically effective measures should be implemented to protect germplasm resources in contracting regions. The findings of this study provide a theoretical basis for addressing desertification resulting from climate change and offer practical insights for the development, utilization, introduction, and cultivation of R. songarica germplasm resources.