bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intake of Trans‐Fat Diet With Prenatal Bisphenol A Exposure Induce Global DNA Methylation in Rats Offspring
Authors: Abulehia Hala , Mohd Nor Noor Shafina , Sheikh Abdul Kadir Siti Hamimah 
Published: February 2025

ABSTRACTBackgroundBisphenol A (BPA) is a ubiquitous industrial compound found in an enormous variety of consumer goods such as plastics, epoxy resins, and thermal paper. Despite its widespread usage, the effects of BPA on the risk and development of metabolic syndrome are not fully understood. Prenatal exposure to BPA has been shown to disrupt the development of offspring's metabolically active tissues and increase their susceptibility to the adverse consequences of a trans‐fat diet (TFD).MethodsIn this experiment, pregnant rats (n = 18) were randomly separated into three groups. These groups were treated from pregnancy day (PD) 2 to PD 21. Subsequently, the male offspring of these rats were provided either a normal‐diet (ND) or a TFD from 3rd postnatal week (PNW) to 14th PNW. Then, protein expression of PPAR‐γ and global DNA methylation were assessed in the adult rat offspring that were exposed to in utero BPA and subjected to postnatal TFD intake.ResultsThe study findings have shown that there was no association between prenatal exposure to BPA and/or TFD consumption and PPAR‐γ protein expression within all the study groups in the liver tissue. On the other hand, changes at the molecular level, as reflected by the global DNA hypermethylation induced by prenatal BPA and postnatal TFD intake in adult male SD rat offspring (PNW 14).ConclusionsThis study underscores the potential impact of prenatal BPA exposure and postnatal TFD intake on epigenetic regulation, as evidenced by global DNA hypermethylation, despite no observable changes in PPAR‐γ protein expression. These findings suggest that early‐life environmental exposures may predispose individuals to metabolic disruptions, including diabetes and obesity, in adulthood or future generations.
The Impact of Climate Change on the Income of Wine Producers in the Bordeaux Region
Authors: Enjolras Geoffroy , Viviani Jean‐Laurent 
Published: February 2025

ABSTRACTIn the Bordeaux region, climate change has a very significant impact on wine production, with an increase in vineyard area, but a decrease in yield and income. We use a Ricardian approach to assess the magnitude of these changes. We combine very detailed individual, structural and financial data at the farm level with weather data to measure the impact of climate change on vineyards. Econometric models highlight the important role of high temperatures and rainfall in reducing yields during the growing season. Farmers respond to these phenomena through a combination of strategies: increasing vineyard area, prioritising operational expenditure over long‐term investment strategies and using adaptive risk management techniques such as irrigation and crop insurance. These results suggest that wine producers are effectively adapting to climate change and its adverse effects on yield and income volatility. Moreover, these strategies are differentiated according to the value and quality of the production.
Optimizing Peripheral Nerve Block Placement in Hip Surgery: A Cadaveric Study Mapping the Posterior Cutaneous Innervation
Authors: Gurney Ziki , Wei Kenneth Saw Kai , Boote Leia , Stolady Daniel Gareth , Fox Benjamin , Norrish Alan R. 
Published: February 2025

ABSTRACTOptimizing analgesia after hip surgery enables more rapid recovery. However, peripheral nerve blocks (PNBs) often fail to provide adequate pain relief in the posterolateral hip as they typically target the lateral cutaneous nerve of the thigh (LCNT). This study aimed to map the nerves innervating the posterolateral hip through analysis of anatomy textbooks (n = 5) and cadaveric dissections (n = 13). The subcostal (SCN), iliohypogastric (IHN), and ilioinguinal (IIN) nerves were identified as key contributors to innervating the posterolateral hip. The optimal site for ultrasound‐guided PNBs to target these three nerves was identified at the “75/25” landmark: 75% horizontally along the 12th rib and 25% vertically down to the iliac crest. Ultrasound‐guided dye injections in cadavers (n = 6) showed that while the “75/25” landmark effectively stained the SCN (6/6) and IHN (4/6), it inconsistently stained the IIN (2/6). A second injection in the posterolateral hip stained branches of the IHN (4/6) and IIN (4/6) but not the SCN (1/6), suggesting the IHN and IIN are the dominant nerves in the posterolateral hip. These findings recommend a more distal injection at the “100/75” landmark to consistently block the IHN and IIN, thereby optimizing postoperative analgesia after hip surgery.
Exploring Therapeutic Change in Indian Clients Experiencing Emotional Abuse: A Social Justice Approach to Counselling
Authors: Cheguvera Natania , Arur Aditi Ashok 
Published: February 2025

ABSTRACTBackgroundThis study examined the lived experiences of emotional abuse (EA) in Indian parent‐adult child relationships, emphasising the intersection of systemic influences in maintaining EA. Employing a social justice framework, the research explored pathways to foster ‘change’ at both individual and societal levels to address EA.MethodsData were collected through semi‐structured interviews with ten participants undergoing therapy, and analysed using Interpretative Phenomenological Analysis.ResultsFour master themes emerged: ‘State of Lack’, ‘Lack of Relatability to Gender and Culture Norms’, ‘Therapy as a Catalyst for Regaining Sense of Self and Empowerment’, and ‘Cultural Shifts, Therapeutic Integration and Redefining Norms to Address Emotional Abuse’.ConclusionThe findings emphasise the contribution of gender and cultural norms in the reinforcement of EA, while highlighting therapy's potential in fostering individual healing while advocating for societal transformation. Our study adds valuable literature to the fields of counselling, social justice research, cultural psychology, social psychology, and feminist psychology, and provides a basis for future research.
Multisite Head and Neck Pediatric Posttransplant Lymphoproliferative Disorder: A Case Report
Authors: Gao Lily , Hoke Austin , Jackson Jarrett , Petrauskas Laura , Mason Emily F. , Sarma Asha , Friedman Debra , Bearl David , Dulek Daniel , Wootten Christopher , Park Jason 
Published: February 2025

ABSTRACTPosttransplant lymphoproliferative disorder (PTLD) can mimic infectious processes in the head and neck. A high index of suspicion for PTLD must be maintained in pediatric transplant patients, and minimal response to antibiotics/corticosteroids should prompt timely biopsy of suspicious tissue to expedite the diagnosis and treatment of PTLD.
Ovarian Dysgerminoma Associated With Pregnancy Presenting as Hemoperitoneum: An Obstetric Case Report
Authors: Gbary‐Lagaud Eléonore , Loba José , Kouakou‐Kouraogo Ramata , Houphouet‐Mwandji Carine , Adjoby Roland 
Published: February 2025

ABSTRACTOvarian dysgerminomas are malignant tumors that are infrequently associated with pregnancy. These tumors are typically detected in cases of abdominal pain or during routine imaging such as ultrasound or magnetic resonance imaging. However, we report a case of ovarian dysgerminoma in an ongoing pregnancy, discovered as a result of hemoperitoneum. A 33‐year‐old patient at 23 weeks of gestation presented with hemorrhagic shock and hemoperitoneum, requiring emergency surgery. During the operation, a large tumor measuring 24 × 29 cm was found in the left ovary, which was completely invaded by the mass but showed no adhesions to adjacent organs. The condition was accompanied by abundant ascites (4.5 L) mixed with blood, caused by bleeding from an ovarian vessel on the surface of the tumor. Histological examination confirmed the diagnosis of dysgerminoma. Haemoperitoneum is a rare but severe complication that can lead to discovering ovarian dysgerminoma. Owing to the low malignancy of this tumor, adnexectomy is an effective emergency treatment, offering favorable maternal and fetal outcomes in early‐stage cases. However, larger case series are required to assess the prognosis of pregnancy associated with dysgerminoma better.
A mm‐Wave Power VCO and Frequency Doubler Based on Class‐C Architecture Using 130 nm CMOS Technology
Authors: Mansour Marwa , Mansour Islam 
Published: February 2025

ABSTRACTThis manuscript introduces a power voltage‐controlled oscillator (PVCO) with a frequency doubler (FD), utilizing a complementary PMOS‐NMOS architecture based on Class‐C operation for millimeter‐wave and fifth‐generation (5G) systems. One output terminal of the VCO core is connected to a power stage operating at the fundamental frequency () in the 21.2–23.2 GHz frequency band. The other output terminal is linked to a FD and a power stage working at the second harmonic frequency (), covering the 42–46.5 GHz frequency range. All inductors are designed on‐chip using HFSS simulation tools, achieving a high‐quality factor, large self‐resonance frequency (SRF), and small die area. To enhance the frequency sensitivity of the PVCO and FD‐PVCO, every band is split into three sub‐bands by manipulating only one‐pin switching voltage. The PVCO operates in the 21.24–23.2 GHz range, achieving a figure of merit (FoM) equal to −194.5 dBc/Hz, a phase noise (PN) equal to −108 dBc/Hz, and a maximum output power () equal to 5.74 dBm. Meanwhile, the FD‐PVCO oscillates in the 42.48–46.4 GHz range, achieving a FoM of −200 dBc/Hz, a PN of −108 dBc/Hz, and an extreme . The proposed design dissipates a DC‐power equal to 2.4 mW and occupies an active area of 0.032 mm2, whereas the overall chip size, including the pads, FD, and power stages, is 0.37 mm2.
Assessing Individual Running Demands in Position Games: A Comparison Between Official Matches and Different Task Sizes in Young Professional Soccer Players
Authors: Asian‐Clemente Jose A. , Beltran‐Garrido Jose Vicente , Requena Bernardo 
Published: February 2025

ABSTRACTThe objectives of this study were to compare external loads between matches and position games based on player roles and to evaluate the load disparities between matches and different position games, individually considering each position. Twenty‐five players (age: 21.9 ± 1.9 years; height: 177.9 ± 5.2 cm; weight: 75.5 ± 4.8 kg) were evaluated during 37 official matches and 18 position games classified according to their pitch sizes: small, medium, and large (50.8 ± 6.6 m2, 80.5 ± 4.6 m2, and 115.9 ± 25.2 m2 relative area per player, respectively). Players were categorized as: central defenders (CD), fullbacks (FB), defensive midfielders (CM), offensive midfielders (OM), wide midfielders (WM), and forwards (F). Using GPS, various metrics were recorded: distance covered (DC), DC > 21 km·h−1, peak speed, maximum accelerations and decelerations, and lower and higher than 3 m·s−2 (Acc<3; Acc>3; Dec<3; and Dec>3, respectively). Variables were normalized per minute (except peak speed, maximum accelerations, and decelerations). In all positions, matches consistently exhibited higher DC > 21 km·h−1 (p < 0.01), peak speed (p < 0.01), ACC<3 (p ≤ 0.01), DEC<3 (p < 0.01), and maximum accelerations and decelerations (p < 0.01). Small and large formats showed the same disparities across all positions (p < 0.05), whereas in medium position games, this trend was observed exclusively among FB and F (p < 0.05). Position games displayed greater ACC>3 and DEC>3 than matches for certain player positions, but these depended on the size of the drill (p < 0.05). Position games present different external loads than matches, depending on the players' positions and the size of these tasks.
Patient‐Related Factors Influencing Motivation to Change in Adolescents With First‐Onset Anorexia Nervosa: A Cross‐Sectional Study
Authors: Mey Elisabeth De , Meijer Marisha N. , Bracké Katrien F. M. , Steegers Cathelijne P. M. , Hillegers Manon H. J. , Danckaerts Marina , White Tonya , Dieleman Gwendolyn C. 
Published: February 2025

ABSTRACTObjectiveMotivation to change significantly impacts treatment outcomes in eating disorders (EDs). This study investigated patient‐related factors associated with motivation to change in adolescents with first‐onset anorexia nervosa (AN). Understanding these factors will help tailor interventions to individual needs, enhancing treatment outcomes.MethodSeventy‐six female adolescents with first‐onset AN completed the Readiness and Motivation Questionnaire (RMQ)—Dutch translation. ED symptoms, body mass index, and comorbidity (depressive, anxiety, obsessive‐compulsive, autism spectrum disorder, and attention deficit and hyperactivity disorder symptoms) were analysed using linear regression analyses. As a secondary aim, the association between specific ED behaviours and motivation to change was analysed. This project was preregistered: https://osf.io/vx9ud/.ResultsAdolescents with more severe ED symptoms, depressive symptoms, and obsessive‐compulsive symptoms, experienced lower motivation to change. The severity of ED symptoms emerged as the most important factor associated with motivation to change, specifically ED symptoms concerning weight and body shape. Additionally, laxative misuse was associated with greater motivation to change.ConclusionsThe link between motivation to change and ED symptoms suggests that early treatment can improve outcomes by reducing ED symptoms and facilitating change. Furthermore, addressing depression during treatment might enhance motivation to change.
Acceptability and somatic mutations in cervicovaginal self‐sampling for early endometrial cancer detection in women with Lynch syndrome
Authors: Peremiquel‐Trillas Paula , Martínez José Manuel , Paytubi Sònia , Frias‐Gomez Jon , Pelegrina Beatriz , Marin Fátima , Benavente Yolanda , Ibáñez Raquel , Barahona Marc , Fernandez‐Gonzalez Sergi , Cárdenas Laura , Taltavull Anna , Darder Esther , de Sanjosé Silvia , Widschwendter Martin , Matias‐Guiu Xavier , Bosch Xavier , Pineda Marta , Ponce Jordi , Brunet Joan , Alemany Laia , Costas Laura 
Published: February 2025

AbstractNew molecular approaches are being developed to detect endometrial cancer using minimally invasive sampling methods. This study aims to evaluate the acceptability of self‐collected cervicovaginal samples among women with Lynch syndrome, a group at high risk for developing endometrial cancer. Participants collected cervicovaginal self‐samples and answered an at‐home acceptability questionnaire in a cross‐sectional study. Self‐samples from a subset of these women were analyzed for somatic mutations using next‐generation sequencing (NGS), targeting a panel of 47 genes. A total of 61 (88.4%) out of 69 eligible women participated in the study. The overall self‐sampling experience was rated good or very good (N = 55, 90.2%). Most of the women were confident about correctly sampling (N = 58, 95.1%), and most reported no or mild pain (N = 56, 91.8%). During self‐sample collection, most women reported feeling calm and comfortable and experiencing safety, privacy, and normality. In a pilot study using a subset of 15 samples, five somatic variants were identified in four self‐samples (4/15, 26.7%) in ACVR2A, ARID1A, APC, and KMT2D. During follow‐up, three out of four women with variants detected in the self‐sample underwent prophylactic hysterectomy at a median of 9.1 months, while one out of four developed endometrial cancer after 3.9 years since the collection of the sample. Self‐sampling is well‐accepted and well‐tolerated in women with Lynch syndrome and could potentially reduce some barriers associated with gynaecological surveillance. Further research is needed to evaluate the feasibility of implementing cervicovaginal self‐collection and the accuracy of molecular testing for gynaecological surveillance in women with Lynch syndrome.
Prognostic significance of lymph node ratio in patients with endometrial cancer: A systematic review and meta‐analysis
Authors: Fanaki Maria , Pergialiotis Vasilios , Koutras Antonios , Perros Paraskevas , Vlachos Dimitrios Efthimios , Daskalakis Georgios , Thomakos Nikolaos 
Published: February 2025

AbstractBackgroundThe ratio of harvested lymph nodes to the number of metastatic nodes is known as the lymph node ratio (LNR) and its prognostic significance was investigated in many types of cancer.ObjectivesHowever, until now, the therapeutic role of lymphadenectomy in the management of endometrial cancer (EC) has remained controversial.Search StrategyThe search strategy involved the Medline, Scopus, Clinicaltrials.gov, Cochrane Central Register of Controlled Trials CENTRAL, and Google Scholar databases.Selection CriteriaWe included prospective and retrospective observational studies.Data Collection and AnalysisThe current systematic review includes seven studies with a total of 6050 patients. From Cox regression analyses, pooled hazard ratios (HRs) were obtained to reduce the confounding effect of other factors that affect the survival outcomes.Main ResultsThe meta‐analysis revealed a significant difference in progression‐free survival in patients with LNR below the cut‐off point in comparison to individuals with LNR above the cut‐off point (HR 2.06, 95% CI 1.57–2.71, data from 6 studies). Similarly, a significantly smaller overall survival was observed among patients with LNR above the cut‐off value (HR 1.99, 95% CI 1.53–2.60; data from five studies).ConclusionsThe results of this systematic review provide strong evidence that LNR could be a prognostic factor for EC patients regarding the need for adjuvant therapy and survival rate. Further studies should focus on the specific cut‐off levels of LNR and the role of the molecular markers in assessing the prognosis of EC patients.
Reshaping the Treatment Landscape of a Galactose Metabolism Disorder
Authors: Estela Rubio‐Gozalbo M. , Naomi Vos E. , Rivera Isabel , Lai Kent , Berry Gerard T. 
Published: February 2025

ABSTRACTThe Leloir pathway was elucidated decades ago, unraveling how galactose is metabolized in the body. Different inborn errors of metabolism in this pathway are known, the most frequent and well‐studied being Classic Galactosemia (CG) (OMIM 230400) due to pathogenic variants in the GALT gene. Substrate reduction using dietary restriction of galactose is currently the only available treatment option. Although this burdensome diet resolves the life‐threatening clinical picture in neonates, patients still face long‐term complications, including cognitive and neurological deficits as well as primary ovarian insufficiency. Emerging therapies aim to address these challenges on multiple fronts: (1) restoration of GALT activity with nucleic acid therapies, pharmacological chaperones, or enzyme replacement; (2) influencing the pathological cascade of events to prevent accumulation of metabolites (Galactokinase 1 (GALK1) inhibitors, aldose reductase inhibitors), address myo‐inositol deficiency, or alleviate cellular stress responses; (3) substrate reduction with synthetic biotics or galactose uptake inhibitors to eliminate the need for lifelong diet; and (4) novel approaches to mitigate existing symptoms, such as non‐invasive brain stimulation and reproductive innovations. Early, personalized intervention remains critical for optimizing patient outcomes. We review the advances in the development of different treatment modalities for CG and reflect on the factors that need to be considered and addressed to reshape the landscape of treatment.
Pre‐Treatment Breast MRI: Clinical Indications, Outcomes, and Future Directions
Authors: Dontchos Brian N. , Phelps Matthew D. , Rahbar Habib , Lam Diana L. 
Published: February 2025

ABSTRACTBreast MRI is the most sensitive modality for assessing the extent of disease in patients with newly‐diagnosed breast cancer because it identifies clinically‐ and mammographically‐occult breast cancers. Though highly sensitive, breast MRI has lower specificity that may result in false positive findings and potential overestimation of disease if additional MRI findings are not biopsied prior to surgery. It had been anticipated that the superior cancer detection rate of pre‐treatment MRI would translate to improved immediate (surgical re‐excision) and long‐term patient outcomes such as breast cancer recurrence and survival rates, but studies have not necessarily supported this assumption. In this review, current recommendations and utilization of breast MRI for pre‐treatment local staging of breast cancer will be presented, with an emphasis on specific clinical scenarios for patient selection and its impact on short‐ and long‐term patient clinical outcomes. We will also present new evidence that pre‐treatment MRI may support de‐escalation of treatment and discuss emerging advanced MRI techniques that may improve diagnostic performance.
Magnetic Resonance Imaging for Dental Pulp Assessment: A Comprehensive Review
Authors: Han Bing , Chen Na , Luo Jin , Afkhami Farzaneh , Peters Ove A. , Wang Xiaoyan 
Published: February 2025

ABSTRACTMagnetic resonance imaging (MRI) has recently emerged as a promising modality for dental applications, offering radiation‐free imaging with superior soft tissue visualization capabilities compared to x‐ray‐based techniques such as spiral or cone beam computed tomography (CBCT). Conventional radiographic methods or CBCT cannot directly assess the condition of the dental pulp due to their primary focus on hard tissue visualization, whereas the dental pulp is primarily composed of connective tissue. Given the advantages of MRI in soft tissue imaging, this review aims to explore the current application of MRI for dental pulp tissue assessment. Relevant studies concerning the application of MRI for visualizing dental pulp were retrieved from databases including PubMed, Embase, and Scopus. The review explored and discussed the advancements in MRI hardware and software related to dental pulp visualization, as well as the advantages and limitations of MRI in dental pulp studies. Despite remaining limitations, such as scanning time and cost considerations, MRI offers notable benefits, including radiation‐free imaging and potentially superior resolution and accuracy compared with other imaging techniques. Consequently, the continued advancement of MRI as a noninvasive diagnostic method in dentistry, particularly for assessing pulp condition, holds substantial promise for improving endodontic diagnosis and subsequent treatment decision‐making.