bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed Tomographic Analysis of Arthroscopic Labral Repair Using Absorbable Knotless Suture Anchors
Authors: Weiser Lori G. , Alexander Susan , Banerjee Sughran , Bashir Waseem A. , Connell David , Wallace Andrew L. 
Published: December 2012

Background We investigated the reconstitution of the glenoid bone after degradation of absorbable knotless suture anchors used for labral repair. Methods Arthroscopic labral repairs performed on 59 shoulders in 55 patients by a single surgeon using knotless poly-L-lactic acid suture anchors were reviewed at a mean of 46.5 months. Computed tomographic scans of the operated shoulder were reviewed by two independent radiologists for the number of drill holes present, as well as the amount of bony reconstitution and the presence of osteoarthritis. Results One hundred and ninety anchors were placed and both radiologists counted 185 drill holes (97%). Agreement between the radiologists was high (kappa = 0.96). The majority of holes had partial bony ingrowth (69% to 71%) and osteolysis was infrequent (6%). The prevalence of degenerative joint disease was 7% to 8%. Conclusions Biodegradable suture anchors are a viable option for labral fixation during arthroscopic shoulder stabilization but, in most cases, the drillholes are not fully replaced with bone and may enlarge, although the effect on clinical outcome is uncertain.
Long‐term efficacy of ustekinumab in patients with moderate‐to‐severe psoriasis treated for up to 5 years in the PHOENIX 1 study
Authors: Kimball A.B. , Papp K.A. , Wasfi Y. , Chan D. , Bissonnette R. , Sofen H. , Yeilding N. , Li S. , Szapary P. , Gordon K.B. ,   on behalf of the PHOENIX 1 investigators
Published: December 2012

AbstractBackground  Ongoing evaluation of biological agents in patients with moderate‐to‐severe psoriasis is needed to support their long‐term use.Objective  To evaluate long‐term efficacy and safety of ustekinumab through 5 years in the PHOENIX 1 study.Methods  Patients were randomized to placebo or ustekinumab (45 mg or 90 mg) at Weeks 0, 4 and every‐12‐weeks thereafter; placebo patients crossed‐over to ustekinumab at Week 12. Clinical response through Week 244 was evaluated using the Psoriasis Area and Severity Index (PASI) in the Overall Population (i.e. patients receiving ≥1 dose of ustekinumab), Initial Responders (i.e. PASI 75 responders [Weeks 28/40] re‐randomized at Week 40 to continue every‐12‐week maintenance) and Partial Responders (i.e. <PASI 75 responders adjusted to every‐8‐week maintenance at Weeks 28 or 40). Safety endpoints were evaluated through Week 264 for the Overall Population.Results Overall, 68.7% (517/753) of ustekinumab‐treated patients completed treatment through Week 244. Initial clinical responses were generally maintained through Week 244 (PASI 75: 63.4% and 72.0%; PASI 90: 39.7% and 49.0%; PASI 100: 21.6% and 26.4%) for patients receiving 45 mg and 90 mg, respectively. Similarly, PASI 75 responses were generally maintained among Initial Responders [79.1% (45 mg) and 80.8% (90 mg)] and Partial Responders [57.6% (45 mg) and 55.1% (90 mg)]. With 3104 patient‐years of follow‐up, rates of overall adverse events (AEs), serious AEs, serious infections, malignancies and major adverse cardiovascular events were generally consistent over time and comparable between doses.Conclusions  Through 5 years of continuous treatment, ustekinumab demonstrated stable clinical response and a safety profile consistent with previous reports.
HPV oral lesions in HIV‐infected patients: the impact of long‐term HAART
Authors: Anaya‐Saavedra Gabriela , Flores‐Moreno Bertha , García‐Carrancá Alejandro , Irigoyen‐Camacho Esther , Guido‐Jiménez Miriam , Ramírez‐Amador Velia 
Published: December 2012

BackgroundSince the introduction of highly active antiretroviral therapy (HAART), an increase in the frequency of human papillomavirus‐associated oral lesions (HPV‐OL) has been observed. Thus, the aim of this study was to determine the prevalence and factors associated with HPV‐OL in Mexican HIV‐infected patients, as well as its genotyping, in the HAART era.MethodsIn a cross‐sectional study developed at an HIV/AIDS referral center in Mexico City, HIV‐infected patients were consecutively included from 2004 to 2011. An oral exam was performed; lymphocyte CD4+ count, HIV‐viral load, CDC‐stage, and HAART use were recorded. HPV‐OL samples were taken for routine histopathological analysis (H‐E) and HPV‐DNA amplification/sequencing. Logistic regression models were performed and the interactions tested using the STATA software.ResultsAmong 787 HIV patients, 55 (6.9%) showed HPV‐OL. HPV‐OLs were independently associated with age (≥40 years) and with a longer time of HAART use (≥12 months). The most frequent lesion was squamous cell papilloma in 22 (40%) cases, followed by multifocal epithelial hyperplasia in 15 (27.3%) cases. Labial mucosa was the most common site involved (56.4%). Of the sequences obtained, 65.4% corresponded to low risk and 11.5% to high risk. Mixed high‐ and low‐risk infection were identified in 7.7% of the cases.ConclusionsHuman papillomavirus‐associated oral lesions were associated with older age and longer HAART use. All lesions were benign in nature and most of the HPV sequences corresponded to low‐risk types. The rise of HPV‐OLs in HIV patients on HAART may be related with the longer life expectancy of individuals with an impaired immune system rather than a direct effect of HAART.
Structure and activity of AbiQ, a lactococcal endoribonuclease belonging to the type III toxin–antitoxin system
Authors: Samson Julie E. , Spinelli Silvia , Cambillau Christian , Moineau Sylvain 
Published: December 2012

SummaryAbiQ is a phage resistance mechanism found on a native plasmid of Lactococcus lactis that abort virulent phage infections. In this study, we experimentally demonstrate that AbiQ belongs to the recently described type III toxin–antitoxin systems. When overexpressed, the AbiQ protein (ABIQ) is toxic and causes bacterial death in a bacteriostatic manner. Northern and Western blot experiments revealed that the abiQ gene is transcribed and translated constitutively, and its expression is not activated by a phage product. ABIQ is an endoribonuclease that specifically cleaves its cognate antitoxin RNA molecule in vivo. The crystal structure of ABIQ was solved and site‐directed mutagenesis identified key amino acids for its anti‐phage and/or its RNase function. The AbiQ system is the first lactococcal abortive infection system characterized to date at a structural level.
Gut microbiota and gastrointestinal health: current concepts and future directions
Authors: Aziz Q. , Doré J. , Emmanuel A. , Guarner F. , Quigley E. M. M. 
Published: December 2012

AbstractBackground The microbial community of the human gut – the enteric microbiota – plays a critical role in functions that sustain health and is a positive asset in host defenses. In recent years, our understanding of this so‐called human ‘super organism’ has advanced, following characterization of fecal metagenomes which identified three core bacterial enterotypes, and based on basic and clinical research into the impact and consequences of microbiota biodiversity and change on gastrointestinal disorders and diseases.Purpose This article considers current knowledge and future perspectives on the make‐up and function of human gut microbiota, with a particular focus on altered microbiota and gastrointestinal disorders, nutritional influences on the gut microbiota, and the consequences for gastrointestinal health, as well as improved understanding of gut‐microbiota–brain communication.
Osteomyelitis of the jaws associated with osteopetrosis: case report of two sisters
Authors: Adachi M. , Iwai T. , Watanuki K. , Masuda G. , Tohnai I. 
Published: December 2012

AbstractOsteopetrosis is a rare metabolic bone disease caused by a congenital defect in the development or function of the osteoclasts, resulting in generalised increase in skeletal mass. Osteomyelitis is a recognised complication, and prevention of dental infections can be difficult. Osteomyelitis is typically located in the mandible; the disease can also occur in the maxilla, but only rarely. We describe two cases of osteopetrosis complicated with osteomyelitis that occurred in sisters. In one sister, osteomyelitis was located in the mandible; in the other sister, the disease occurred in the maxilla. The sisters received antibiotic treatment, as well as incision and drainage of the fluctuant areas and removal of sequestra with minimal surgical trauma, after which they both improved satisfactorily. These cases underscore the importance of screening family members of patients with osteopetrosis for early detection and appropriate intervention.
Metastatic colorectal adenocarcinoma of the jaw – a case report
Authors: Murugaraj V. , Bischoff P. , Fasanya S. , Hameed S. , Suman A. 
Published: December 2012

AbstractMetastatic tumours of the oral region are far less frequent than the primary tumours. The major primary sites of carcinoma metastasising to the oral cavity are the lungs and breast, but there are several reported cases of other primary sites. To our knowledge, oral metastases from a primary colorectal malignancy are a very rare occurrence. We present a case of metastatic adenocarcinoma of the oral region from a colorectal primary malignancy.We discuss the clinical and histopathological aspects of this rare condition and the management of this patient.
Treatment of Phantom Limb Pain by Cryoneurolysis of the Amputated Nerve
Authors: Moesker Albert A. , Karl Helen W. , Trescot Andrea M. 
Published: December 2012

AbstractThe pathophysiology of phantom limb pain (PLP) is multifactorial. It probably starts in the periphery and is amplified and modified in the central nervous system. A small group of patients with PLP were questioned as to the portion of the phantom limb affected by pain (eg, “great toe,” “thumb”). In the stump, the corresponding amputated nerve was located with a nerve stimulator. With correct placement and stimulation, the PLP could then be reproduced or exacerbated. A small dose of local anesthesia was then injected, resulting in the disappearance of the PLP. If a peripheral nerve injection gave temporary relief, our final treatment was cryoanalgesia at this location. Evaluation of 5 patients, followed for at least 2.5 years, yielded the following results: 3 patients had excellent results (100%, 95%, and 90% decrease in complaints, respectively), 1 patient had an acceptable result (40% decrease), and 1 patient had only a 20% decrease in pain. Although both central and peripheral components are likely involved in PLP, treatment of a peripheral pain locus with cryoanalgesia should be considered. We propose the identification of a peripheral etiology may help match patients to an appropriate therapy, and cryoanalgesia may result in long‐term relief of PLP.
Correct Voting in Direct Legislation
Authors: Milic Thomas 
Published: December 2012

AbstractCorrect voting in elections has been extensively analysed in the recent past. However, thus far, correct voting in direct legislation has hardly been investigated. This is all the more surprising since direct legislation is a more demanding form of democracy and, thus, to vote one's true preferences in direct legislation represents a greater challenge than picking the “right” party or the “right” candidate at elections. Moreover, the few researches on the correctness of individual referendum votes used a measurement method that we think has some methodological shortfalls. Instead, we want to propose another better‐suited method of measuring correct voting in direct legislation settings. This method makes use of voters' stances on the issue at stake. Besides, we will scrutinize the share of correct voting as well as its determinants on the Swiss popular vote of November 2009, which included three rather different propositions. The study shows that a majority of Swiss voters are indeed able to vote their true preferences. The ability to vote correctly depends primarily on the individual voter's project‐specific knowledge, but also, under certain circumstances, on the use of heuristics.
Die Ausgaben der Schweizer Kantone ‐ Eine Fuzzy Set QCA
Authors: Good Marin , Hurst Simon , Willener Rahel , Sager Fritz 
Published: December 2012

AbstractDer Artikel untersucht die Frage, welche Faktoren die Ausgaben der 26 Schweizer Kantone beeinflussen. Während die Frage bereits mehrfach mit statistischen Ansätzen untersucht wurde, hat die vorliegende Studie einen alternativen Fokus, indem sie eine konfigurative Perspektive einnimmt. Ausgangspunkt sind die Ergebnisse der Studie von Vatter und Freitag von 2002, welche mit aktualisierten Daten der Jahre 2000 bis 2006 in einer Fuzzy Set QCA auf ihre kombinierte Wirkungsweise hin untersucht werden. Die Resultate streichen die zentrale Bedeutung von Transferzahlungen hervor und stützen so die These des Flypaper Effect aus der ökonomischen Theorie.
Regulation of Liberalised Network Industries: Infostructure as a Missing Link
Authors: Pflieger Géraldine , Csikos Patrick 
Published: December 2012

AbstractThe aim of this paper is to evaluate how infostructure has been reformed in the liberalisation process of network industries, which has involved third party access to the network through a comparison of the electricity, railway, and civil aviation sectors in Switzerland. Our theoretical argument posits that infostructure is a missing link in the study of the regulation of liberalised network industries. Infostructure is defined as the control and command services that are necessary for monitoring the access to and optimising the uses of infrastructure. Our empirical comparison of the sectors aims at answering the principle question: What is the impact of the management of infostructure on the liberalisation process and the structure of liberalising markets? This study of the liberalisation of network industries in Switzerland highlights the potential strategic function of infostructure in the context of opening to competition and internationalising markets. Infostructure management can impact infrastructure ownership and service operation in terms of market structure and constrain access to the infrastructure and the market. Infostructure could also weaken the capacity to regulate the entire sector from regulatory agencies, particularly when self‐regulatory arrangements control third party access to the network.
Extracorporeal membrane oxygenation as treatment for acute respiratory failure and subsequent pneumothorax caused by Pneumocystis jirovecii pneumonia in a kidney transplant recipient
Authors: Wu Y.‐S. , Lin N.‐C. , Chen I.‐M. , Chang S.‐C. , Wang F.‐D. , Huang Y.‐C. , Wu T.‐H. , Loong C.‐C. 
Published: December 2012

AbstractAcute respiratory failure (ARF) accompanied by pneumothorax caused by Pneumocystis jirovecii pneumonia (PJP) is often fatal. We present our experience using extracorporeal membrane oxygenation as treatment for ARF and subsequent pneumothorax caused by PJP in a kidney transplant recipient.
Treating Animal Bites: Susceptibility of Staphylococci from Oral Mucosa of Cats
Authors: Muniz I. M. , Penna B. , Lilenbaum W. 
Published: December 2012

SummaryInfected wounds determined by cats’ bites represent high costs to public health, and their adequate treatment relies on the knowledge of the antimicrobial susceptibility of bacterial agents found in the oral microbiota. Members of the genus Staphylococcus sp. belong to the microbiota of the oral mucosa of cats and are frequently involved in secondary infections of these wounds. This study aimed to evaluate the antimicrobial susceptibility of Staphylococcus species isolated from oral mucosa of cats. Samples were collected from 200 clinically healthy cats and processed by standard bacteriological methods and tested for susceptibility to a panel of 16 antimicrobials. A total of 212 staphylococci isolates were obtained from 141 of the 200 cats (70.5%), and more than one colony was recognized in 53 cases. Coagulase‐negative species were most frequently found (89.6%) distributed among Staphylococcus xylosus (50.9%), Staphylococcus felis (27.4%), Staphylococcus simulans (6.1%) and Staphylococcus sciuri (5.2%). Coagulase‐positive species (10.4%) were distributed among Staphylococcus aureus (4.7%) and Staphylococcus intermedius group (SIG) (5.7%). Regarding to antimicrobial resistance, 178 isolates (83.9%) were resistant to at least one antimicrobial, and rifampicin showed the best results with 100% of sensitive strains. Conversely, high rates of resistance were observed for penicillin and tetracycline (56.1%). The 212 staphylococci isolates and 30 (14.1%) strains were resistant to methicillin (on the disc susceptibility test) and may be preliminarily considered as methicilin‐resistant staphylococci. In conclusion, this study reports important rates of antimicrobial resistance among the species of Staphylococcus isolated from clinical specimens of cats, which must be considered for the treating of cats’ bites in humans.
Sidestep cutting technique and knee abduction loading: implications for ACL prevention exercises
Authors: Kristianslund Eirik , Faul Oliver , Bahr Roald , Myklebust Grethe , Krosshaug Tron 
Published: December 2012

BackgroundSidestep cutting technique is essential in programmes to prevent anterior cruciate ligament (ACL) injury. A better understanding of how technique affects potentially harmful joint loading may improve prevention programmes. The purpose of this study was to investigate the effect of sidestep cutting technique on maximum knee abduction moments.MethodsCross-sectional study. Whole-body kinematics and knee joint kinetics were calculated in 123 female handball players (mean±SD, 22.5±7.0 years, 171±7 cm, 67±7 kg) performing sidestep cutting. Three cuts from each side were analysed. Linear regression was applied between selected technique factors and maximum knee abduction moment during the first 100 ms of the contact phase. Furthermore, we investigated to what degree the abduction moment originated from the magnitude of the ground reaction force (GRF) or the knee abduction moment arm of the GRF.FindingsTechnique factors explained 62% of the variance in knee abduction moments. Cut width, knee valgus, toe landing, approach speed and cutting angle were the most significant predictors. An increase in one of these factors of 1 SD increased the knee abduction moment from 12% to 19%. The effect of the moment arm of the GRF was more important than the force magnitude for maximum knee abduction moments.InterpretationLower knee abduction loads during sidestep cutting may be achieved if cuts are performed as narrow cuts with low knee valgus and toe landings. These factors may be targeted in ACL injury prevention programmes.
Transdiagnostic, affect-focused, psychodynamic, guided self-help for depression and anxiety through the internet: study protocol for a randomised controlled trial
Authors: Johansson Robert , Hesser Hugo , Ljótsson Brjánn , Frederick Ronald J , Andersson Gerhard 
Published: December 2012

IntroductionCognitive behaviour therapy delivered in the format of guided self-help via the internet has been found to be effective for a range of conditions, including depression and anxiety disorders. Recent results indicate that guided self-help via the internet is a promising treatment format also for psychodynamic therapy. However, to date and to our knowledge, no study has evaluated internet-delivered psychodynamic therapy as a transdiagnostic treatment. The affect-phobia model of psychopathology by McCulloughet alprovides a psychodynamic conceptualisation of a range of psychiatric disorders. The aim of this study will be to test the effects of a transdiagnostic guided self-help treatment based on the affect-phobia model in a sample of clients with depression and anxiety.Methods and analysisThis study will be a randomised controlled trial with a total sample size of 100 participants. The treatment group receives a 10-week, psychodynamic, guided self-help treatment based on the transdiagnostic affect-phobia model of psychopathology. The treatment consists of eight text-based treatment modules and includes therapist contact in a secure online environment. Participants in the control group receive similar online therapist support without any treatment modules. Outcome measures are the 9-item Patient Health Questionnaire Depression Scale and the 7-item Generalised Anxiety Disorder Scale (GAD-7). Process measures that concerns emotional processing and mindfulness are included. All outcome and process measures will be administered weekly via the internet and at 6-month follow-up.DiscussionThis trial will add to the body of knowledge on internet-delivered psychological treatments in general and to psychodynamic treatments in particular. We also hope to provide new insights in the effectiveness and working mechanisms of psychodynamic therapy based on the affect-phobia model.
Characterising physician listening behaviour during hospitalist handoffs using the HEAR checklist
Authors: Greenstein Elizabeth A , Arora Vineet M , Staisiunas Paul G , Banerjee Stacy S , Farnan Jeanne M 
Published: December 2012

BackgroundThe increasing fragmentation of healthcare has resulted in more patient handoffs. Many professional groups, including the Accreditation Council on Graduate Medical Education and the Society of Hospital Medicine, have made recommendations for safe and effective handoffs. Despite the two-way nature of handoff communication, the focus of these efforts has largely been on the person giving information.ObjectiveTo observe and characterise the listening behaviours of handoff receivers during hospitalist handoffs.DesignProspective observational study of shift change and service change handoffs on a non-teaching hospitalist service at a single academic tertiary care institution.MeasurementsThe ‘HEAR Checklist’, a novel tool created based on review of effective listening behaviours, was used by third party observers to characterise active and passive listening behaviours and interruptions during handoffs.ResultsIn 48 handoffs (25 shift change, 23 service change), active listening behaviours (eg, read-back (17%), note-taking (23%) and reading own copy of the written signout (27%)) occurred less frequently than passive listening behaviours (eg, affirmatory statements (56%) nodding (50%) and eye contact (58%)) (p<0.01). Read-back occurred only eight times (17%). In 11 handoffs (23%) receivers took notes. Almost all (98%) handoffs were interrupted at least once, most often by side conversations, pagers going off, or clinicians arriving. Handoffs with more patients, such as service change, were associated with more interruptions (r=0.46, p<0.01).ConclusionsUsing the ‘HEAR Checklist’, we can characterise hospitalist handoff listening behaviours. While passive listening behaviours are common, active listening behaviours that promote memory retention are rare. Handoffs are often interrupted, most commonly by side conversations. Future handoff improvement efforts should focus on augmenting listening and minimising interruptions.