bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Method to Measure Dual-Task Capacity in Young Football Players: A Preliminary Study
Authors: Uysal Özgün , Atalay Güzel Nevin , Bayrakcı Tunay Volga , Fırat Tüzün 
Published: August 2024

Context
When deciding to return to sport, in the literature, evaluations based on physical abilities have usually been used. However, in the current literature, we have been urged to use more than physical performance evaluations. Classical dual-task testing methods do not simulate in-game loads and cannot sufficiently measure football players’ dual-task capacity.

Objective
To create a dual-task test that would simulate football players’ in-game situations and measure their capacity.

Design
Cross-sectional study.

Setting
Football pitch.

Patients or Other Participants
Twenty-two football players (age = 17.37 ± 0.52 years) who played in a professional club (U19, elite league) were recruited for our study.

Intervention(s)
A novel dual-task test with questions containing scenarios from a football game to cognitively load players while they are performing a modified t test.

Main Outcome Measure(s)
After the warmup period, participants attended 4 tests in random order: juggling (foot), speed dribbling, long passing, and novel dual-task tests.

Results
No significant relationship was found between physical performance parameters and dual-task parameters (all P &gt; .05). A significant increase was found in the completion time of the modified t test when performed under the dual-task condition (Z = −7.568, P &lt; .001). The increase in completion time was 2.14 ± 1.29 seconds. This duration difference was calculated as 22.79% ± 14.58%, as dual-task cost.

Conclusions
Our test provides a new method to measure athletes’ dual-task capacity, which is not related to physical performance and cannot be measured with current tests. This test also showed players with lower dual-task ability could not keep up their performance under dual-task conditions, such as passing a ball to a teammate when being pressed by an opponent. Players with good dual-task ability could maintain their performance (were affected only up to 10%); players with poor dual-task ability could not maintain their performance and were affected by up to 50% (with a mean of 22.79%).
Significance of incarnation in gospel contextualisation and communication interculturally
Authors: Muswubi Takalani A. 
Published: August 2024

This article analyses the missional significance of John 1:14 in gospel contextualisation and communication interculturally. All theologies are contextual within an unchanging divine word of God. After the four-decade long contestation, which was at times complex, if not complicated, the consensus was reached between the Evangelical and the Ecumenical scholars. The aftermath of it has a far-reaching implication for an effective and efficient contextualisation and communication of the gospel interculturally. In this regard, the question is: how to maximise an effective and efficient communication of the gospel interculturally? The goal is to point out the significance of John 1:14 in the whole debate for effective and efficient gospel contextualisation and communication interculturally. It is from that context that this article analyses John 1:14 from a missional perspective with an aim to discuss three aspects: firstly, the basic nature of incarnation as a divine accommodation; secondly, the critical debate of gospel contextualisation and communication since the 1970s; and thirdly, the ultimate missional perspective of incarnation as a holistic and divine model of accommodation for effective and efficient gospel contextualisation and communication. And lastly the concluding remarks.Intradisciplinary and/or interdisciplinary implications: This article contributes to the understanding of the nature and significance of incarnation based on John 1:14. It aims to address the ongoing contextualisation debate from the 1970s until today and propose effective ways of contextualising and communicating the gospel in a multicultural South African context and beyond.
Impact of Urinary Tract Infection on Progression of Renal Scars and Formation of New Scars in Patients with Primary Vesicoureteric Reflux
Authors: Sohail Ahmad Md. , Satapathy Amit Kumar , Agrawal Kanhaiyalal , Das Kanishka , Pati Akash Bihari 
Published: August 2024

Abstract

Introduction:
Primary vesicoureteric reflux (VUR) is a prevalent cause of end-stage renal failure in children. Scars on radionuclide imaging indicate irreparable damage to the growing kidneys. This study aims to determine whether a urinary tract infection (UTI) associated with primary VUR promotes the development of new renal scars or progression in the pre-existing ones.

Materials and Methods:
Children with primary VUR on continuous antibiotic prophylaxis at a tertiary teaching hospital’s paediatric nephrourology clinic were observed prospectively. At recruitment, a renal cortical (dimercaptosuccinic acid [DMSA]) scan was done, and the children were followed up every 3 months. Breakthrough UTIs were documented, and follow-up DMSA scans were performed to document new scarring/grade advancement of existing scars in the renoureteric units (RUUs).

Results:
Seventy-two RUUs in 36 patients were monitored. Fifty-four (75%) RUUs were exposed to VUR of different grades, and 46 (85.1%) had a UTI. On the DMSA scan, these showed new scar development in 10/18 (55%) RUUs and scar progression in 13/28 (46.4%) RUUs. Of the 8 RUUs with VUR and without UTI, new scars manifest in 4/5 (80%) and progressed in 1/3 (33%). On univariate analysis, there was no significant difference in the formation of new scars or scar advancement on the DMSA scan between RUU with VUR and UTI and those without UTI. There was a significant positive correlation between the scarring on DMSA scan and the grade of reflux (P < 0.001).

Conclusion:
Primary VUR patients had fresh or progressed scarring regardless of urinary infection. A higher VUR grade at presentation was a significant risk factor for scarring.
Management of biliary calculi through Ayurveda - A case report
Authors: Jangid Sushil Kumar , Binorkar Sandeep Vishnu , Chhatbar Disha Kirtibhai , Ravi Arun Kumar 
Published: August 2024

Abstract
Biliary calculi, commonly known as gallstones, pose a significant health concern globally, often necessitating invasive interventions. This case report documents the successful management of biliary calculi using Ayurvedic principles in a 34-year-old male patient presenting with recurrent biliary colic and evidence of multiple gallstones on ultrasound imaging. The patient underwent a comprehensive Ayurvedic treatment regimen, including dietary modifications and lifestyle adjustments, tailored to balance the aggravated Doshas (fundamental constituents of the body) implicated in the pathogenesis of biliary calculi. Follow-up assessments demonstrated a remarkable reduction in the size and number of gallstones, accompanied by significant alleviation of symptoms and improvement in overall well-being. This case highlights the efficacy of Ayurvedic interventions in managing biliary calculi, offering a safe and holistic approach to treatment while addressing the underlying imbalances in the body. Furthermore, it underscores the importance of individualized therapeutic strategies in Ayurveda, emphasizing the integration of dietary and lifestyle modifications alongside Ayurveda management to achieve favorable outcomes in patients with biliary calculi. Additional research and clinical trials are warranted to validate the efficacy and elucidate the mechanisms of Ayurvedic interventions in the management of biliary calculi.
Safety profile of Naga Bhasma prepared by two classical methods
Authors: Tate Pravin M. , Patgiri B. J. , Prajapati P. K. , Ravishankar B. 
Published: August 2024

Abstract

Background:

Naga Bhasma (NB) (incinerated lead) has been indicated as a remedy for the treatment of a wide range of diseases including Prameha (diabetes), Kasa (cough), Raktapradara (menorrhagia), Shukradosha (defects in semen), etc., However, improperly prepared NB can cause harmful effects on the human body. In modern science also, lead consumption has been accepted to produce toxicity.

Aim:
The present study was undertaken to elucidate and compare the toxicity profile of two samples of NB prepared by two different methods to ascertain the safety aspects.

Materials and methods:
In the first method, NB was prepared by using Parada (mercury), Gandhaka (sulfur), and Nimbu Swarasa (juice of Citrus medica var acida of Watt). In the second method, NB was prepared by using Ashwattha-Twaka-Churna (Ficus religiosa L.), Manahshila (realgar) (Ariloha), and Nimbu Swarasa. In both methods, 30 calcination cycles were given. Charles foster albino rats were used for the pharmacological study. Acute oral toxicity study was carried out as per organization for economic cooperation and development (OECD) 425 and chronic oral toxicity study was carried out as per OECD 408 (90-day oral repeated dose toxicity study). Acute oral toxicity study was conducted at five dose levels, namely 100, 250, 500, 1000, and 2000 mg/kg body weight. Chronic toxicity was carried out at a dose level of 62.5 mg/kg body weight. Animals were sacrificed on the 91st day by cervical dislocation. Blood was collected from the jugular vein and sent for hematological and biochemical investigations were done. Organs were used for histopathological studies. The data were analyzed by unpaired t-test.

Results:
No mortality was observed in the acute toxicity study. Chronic toxicity study shows that both the test drugs do not produce significant toxicity, but both were not completely free from adverse effects at the dose level studied.

Conclusion:
The study shows that both the test drugs do not produce significant toxicity, but they are not completely free from adverse effects at the dose level studied.
Hyaluronic acid induced blindness and orbital ischemic syndrome: a case report
Authors: Turcio-Aceves Octavio , Carrillo-Haro Emma P. , Gutiérrez-García Diana K. , Cárdenas-Belaunzarán Jorge 
Published: August 2024

The incidence of filler-induced blindness is unknown due to the few reported cases in the literature, nevertheless, it represents a devastating complication. There is no effective treatment for the filler-induced blindness and ophthalmoplegia. However, retrobulbar hyaluronidase treatment has been used with some apparent beneficial results.
We report a case of a 29-year-old female patient who presented with right eye blindness, ophthalmoplegia, and ptosis secondary to dorso-nasal hyaluronic acid injection as a cosmetic treatment. She was treated immediately with intravenous corticosteroids and dorso-nasal and retrobulbar hyaluronidase in an outpatient clinic. After 6 days, the patient was admitted to our institution with a clinical diagnosis of ptosis, ophthalmoplegia, ischemic ocular syndrome, and ophthalmic and central retinal artery occlusion in her right eye. The ptosis and eye movements improved on her follow-up, but the vision loss was permanent due to severe optic nerve and retinal ischemia. Brain MRI ruled out central nervous system involvement.
Macular perfusion, thickness, and sensitivity in phacovitrectomy versus lens-sparing vitrectomy in rhegmatogenous retinal detachment
Authors: Abdel Kader Ahmed A. , Abdelmalak Mina , Elnahry Ayman G. , Ghalwash Dalia A. , Esmat Soheir , Shuaib Asmaa 
Published: August 2024

Purpose
The aim of this study was to compare phacovitrectomy (phacoPPV) to lens-sparing pars plana vitrectomy (PPV) with respect to macular perfusion, thickness, and sensitivity in phakic patients with rhegmatogenous retinal detachment.

Patients and methods
This is a prospective, comparative, nonrandomized, interventional study that included 31 phakic eyes with primary rhegmatogenous retinal detachment. The patients were divided into two groups according to the preoperative lens status: group A who had significant cataract and group B who did not have significant cataract. Group A included 17 eyes for which phacoPPV was performed, while group B included 14 eyes for which lens-sparing PPV was performed. All patients were preoperatively evaluated clinically and with A-scan ultrasonography and were followed up for 4 months after surgery. Optical coherence tomography angiography (OCTA) and microperimetry were done at 2 and 4 months, postoperatively.

Results
The OCTA showed that the lens-sparing PPV was associated with significantly larger foveal avascular zone area (0.4±0.2 mm2) compared to the phacoPPV (0.2±0.1 mm2) at 2 months (P=0.048), as well as at 4 months (0.4±0.1 mm2vs. 0.2±0.1 mm2, respectively, P=0.044). However, the foveal avascular zone perimeter showed no statistically significant differences between the two groups at 2 and 4 months postoperatively. At 2 months, the deep vascular plexus (DVP) parafoveal vessel density was statistically significantly higher in the phacoPPV group (47.9±4.7%) compared to the PPV group (36.4±11.9%) (P=0.048), while at 4 months it was the DVP foveal vessel density that showed a significantly higher mean in the phacoPPV group (35.4±11.9%) compared to the PPV group (20.3±16.1%) (P=0.036). No other statistically significant intergroup differences were found with respect to other parameters for macular perfusion, and other DVP parameters. Similarly, the macular sensitivity, as well as the ganglion cell complex, and the central subfield thicknesses were comparable between the two groups. The visual outcome was also comparable at 2 and 4 months between the two groups.

Conclusion
PhacoPPV and lens-sparing vitrectomy were comparable with respect to OCTA, microperimetry, and visual acuity. The limited differences are too preliminary and the decision to do phacoPPV rather than lens-sparing PPV needs to be based on other determinants like the presence of preoperative lens opacity.
Manually performed limbal relaxing incisions versus femtosecond laser-guided astigmatic keratotomy for correction of corneal astigmatism after phacoemulsification
Authors: Rashwan Ashraf , Natag Ali , Wasfi Ehab , Lotfy Hassan , Shehata Mohamed 
Published: August 2024

Purpose
This study aimed to evaluate the safety and efficacy of manually performed limbal relaxing incisions (LRIs) compared with femtosecond laser-guided astigmatic keratotomy (FLAK) in the management of corneal astigmatism after phacoemulsification.

Patients and methods
This is a prospective, comparative, randomized, interventional study that was conducted from March 2018 to September 2022. It included 56 patients (74 eyes) who had corneal astigmatism after conventional phacoemulsification. They were classified into two groups. Group A included 34 patients (41 eyes) for whom manual LRIs using a diamond knife were performed and group B included 22 patients (33 eyes) for whom FLAK was performed. The preoperative evaluation included manifest refraction, uncorrected distance visual acuity, best corrected distance visual acuity, slit lamp examination of the cornea, intraocular pressure measurement, and fundus examination. Corneal astigmatism in diopters (D) was established by corneal tomography and Scheimpflug imaging (Pentacam). Postoperative follow-up visits were scheduled on the first day, at 1 week, 1 month, and 3 months after surgery. Postoperative evaluation included a slit lamp examination for the incisions, uncorrected distance visual acuity, manifest refraction, and Pentacam to evaluate corneal astigmatism.

Results
The mean topographic corneal astigmatism was reduced from 3.36±1.66 D to 1.07±1.11 D, 3 months postoperatively in the LRIs group with a statistically highly significant difference (P=0.000) and from 3.66±1.82 D to 1.19±1.26 D in the FLAK group with a statistically highly significant difference (P=0.000). The mean topographic corneal astigmatism 3 months postoperatively showed a statistically nonsignificant difference between the two groups (P=0.665). Although there was no statistically significant difference between the two groups, the mean arithmetic reduction of astigmatism was higher in the FLAK group (2.47 D) than in the LRIs group (2.29 D). The surgery was uneventful in 92.68% of the cases in group A with only 7.32% showing nonserious corneal perforation, while in group B, the surgery was uneventful in 97% of the cases with only 3% showing nonserious corneal perforation with a statistically nonsignificant difference between the two groups (P=0.431).

Conclusion
Both manually performed LRIs and FLAK were safe, predictable, and effective methods for correcting pre-existing or surgically induced corneal astigmatism after phacoemulsification with a nonsignificant difference in visual and corneal topographic outcomes between the two methods.
Safety and Efficacy of Mitomycin C: Augmented Trabeculectomy: Subtenon’s Injection versus Sponge Application
Authors: Sedani Kanan Vimal , Bhagat Purvi Raj , Chauhan Abhishek Suryakant 
Published: August 2024

Abstract

Objective:
The objective of the study was to study the safety and efficacy of subtenon injection of mitomycin C (MMC) versus sponge application of MMC during trabeculectomy.

Materials and Methods:
Thirty-seven patients having primary glaucoma warranting trabeculectomy were enrolled in the study and their forty eyes were alternately allocated into either of the two groups: subtenon injection (ST) of 0.1 mL of 0.01% of MMC or sponge application (SP) of 0.02% of MMC and were operated by a single surgeon and followed for 3 months. The outcome was analyzed primarily based on reduction in intraocular pressure (IOP) and bleb morphology.

Results:
Similar outcome in terms of complete success (ST – 90% and SP – 85%), qualified success (ST – 5% and SP – 5%), and failure rate (ST – 5% and SP – 10%) was seen at the end of 3 months. The absolute reduction in IOP from the baseline was −10.00 ± 3.67 mmHg (−41.2% ± 12.30) in ST versus −8.90 ± 5.56 mmHg (−35.9% ± 16.1) in the SP group at the end of 3 months. At the end of 3 months, blebs in the ST group had low-to-medium height and in the SP group had low height. Blebs in both the groups were diffuse with mild vascularity. Antiglaucoma medications required postoperatively were 0.20 ± 0.62 versus 0.40 ± 1.10 in the ST and SP group, respectively. The duration of surgery was 19.85 ± 0.75 min in the ST group versus 22.50 ± 0.51 min in the SP group.

Conclusion:
Subtenon injection of MMC is as efficacious and safe as the conventional sponge application technique.
Dermatological Enigma Unveiled: A Rare Case Report on Dowling-Degos Disease
Authors: Goswami Parth Rajendragiri , Pathania Yashdeep Singh , Singh Gyanendra , Patel Tarang , Agarwal Ashwini 
Published: August 2024

Abstract
Dowling-Degos disease (DDD) is an extremely rare hereditary skin condition characterized by the development of painless, small-sized pigmented patches known as macules or keratotic papules. Typically inherited in an autosomal dominant manner, DDD primarily manifests in adulthood, with onset occurring between the ages of 30 and 40 years, and a higher prevalence among females. Although DDD shares clinical similarities with other reticulated pigmentary disorders such as dyschromatosis symmetrica hereditaria, dyschromatosis universalis hereditaria, and reticulate acropigmentation of Kitamura, its distinctive histopathological features set it apart. A 50-year-old female patient presented with hyperpigmented lesions since infancy, predominantly located in flexural areas, prompting consideration of endogenous eczema or DDD. Despite the absence of a family history and normal laboratory test results, a biopsy confirmed the diagnosis based on characteristic histological findings. The identification of DDD underscores the importance of considering rare dermatological entities in differential diagnosis, especially when clinical presentation aligns with established criteria. Further research and awareness are essential for enhancing our understanding and management of this intriguing skin condition.
Nitric Oxide Synthase 3 Gene Polymorphisms and Their Association with Acute Myocardial Infarction and Chronic Stable Angina: A Case–Control Study from Northern India
Authors: Kumar Sunil , Juyal Deepak , Pandey Arun , Tomar Preeti , Sagar Vinay , Yadav Rakesh , Saxena Renu 
Published: August 2024

Abstract

Background:
Coronary artery disease (CAD) that encompasses acute myocardial infarction (AMI), chronic stable angina (CSA), and unstable angina (UA) has numerous known risk factors. Genetic predispositions contribute as major risk in the development of CAD and the genes regulating atherosclerosis are important for disease prevention. Nitric oxide synthase 3 (NOS3) gene responsible for nitric oxide (NO) production is of special importance.

Aim:
To evaluate the role of three NOS3 polymorphisms (-786C/T, 894G/T, and 4a4b) in patients with CAD, particularly in AMI and CSA and their comparison with healthy controls.

Materials and Methods:
One hundred patients in each AMI and CSA group and 100 controls were included and were typed for three NOS3 polymorphisms (-786C/T, 894G/T, and 4a4b) by polymerase chain reaction–restriction fragment length polymorphism. Plasma NO metabolites (NOx) were also evaluated.

Results:
A significant association of 894G/T polymorphism with AMI in dominant model (P = 0.052) and with CSA in dominant and codominant models was detected (P = 0.008 and P = 0.006, respectively). Plasma NO levels were found to be significantly higher (P < 0.0001) in healthy controls (43.80 ± 6.28) compared to AMI and CSA patients (37.05 ± 6.75 and 38.67 ± 5.61). No significant association of -786C/T and 4a4b polymorphism with AMI and CSA risk under recessive, dominant, and codominant models was detected.

Conclusion:
Our study revealed a significant association of 894G/T polymorphism with AMI and independent association of NOx levels with CAD, indicating high risk of CAD in the North Indian population. Our findings will be helpful in identifying the genetic risk factors associated with CAD and better management of the diagnostic as well as therapeutic measures.
Assessing the Safety of a Novel Monoclonal Antibody Cocktail for Postexposure Prophylaxis in Category III Animal Exposures
Authors: Singh Amandev , Sibia Raminderpal Singh , Oberoi Simmi , Bhatia Lovleen , Kaushal Sachin , Dutta Trayambak , Mahajan Manish , Desai Samir 
Published: August 2024

Abstract

Background:
TwinRab™ is a novel life-saving biological containing two monoclonal antibodies (docaravimab and miromavimab) essential for all age victims of category III animal exposures. It effectively neutralizes rabies and similar viruses at the exposure site until the body generates vaccine-induced antibodies. This postmarketing surveillance study assesses the safety of TwinRab™ in current postexposure prophylaxis (PEP) use and aims to reinforce its safety data for future applications.

Methods:
The prospective, open-label observational study was conducted on patients with the World Health Organization category III animal exposures at a government hospital in a northern region of India, by a suspected rabid animal. The study protocol included administering TwinRab™ (40 IU/kg) and a full course of anti-rabies vaccination as PEP.

Results:
Out of 405 participants, 404 completed the study as per the protocol. Adverse events (AEs) occurred in 12.35% of cases, with 9.88% local AEs (primarily pain and tenderness) and 2.47% systemic AEs (fever, malaise, and myalgia). All AEs were mild and resolved without complications. Most participants (88.9%) and investigators (89.1%) rated TwinRab™’s tolerability as excellent.

Conclusion:
The present study demonstrates the evidence of a satisfactory safety profile along with better tolerability of TwinRab™ (40 IU/kg) for category III animal exposures and supports its continued usage.