bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of migraine and anxiety disorders on painful physical symptoms among patients with major depressive disorder
Authors: Hung Ching-I , Liu Chia-Yih , Chen Ching-Yen , Yang Ching-Hui , Wang Shuu-Jiun 
Published: November 2014

Abstract

Background
No study has simultaneously investigated the impacts of migraine and anxiety disorders on painful physical symptoms (PPS) among patients with major depressive disorder (MDD). The study aimed to investigate this issue.

Methods
This open-label study enrolled 155 outpatients with MDD, who were then treated with venlafaxine 75 mg per day for four weeks. Eighty-five participants with good compliance completed the treatment. Migraine was diagnosed according to the International Classification of Headache Disorders. MDD and anxiety disorders were diagnosed using the Structured Clinical Interview for DSM-IV-TR. The visual analog scale (VAS) was used to evaluate the severity of eight PPS. Multiple linear and logistic regressions were used to investigate the impacts of migraine and anxiety disorders on PPS.

Results
Compared with patients without migraine, patients with migraine had a greater severity of PPS at baseline and post-treatment. After controlling for demographic variables and depressive severity, migraine independently predicted the intensities of eight PPS at baseline and four PPS post-treatment. Moreover, migraine independently predicted poorer treatment responses of chest pain and full remission of pains in the head, chest, neck and/or shoulder. Anxiety disorders predicted less full remission of pains in the abdomen and limbs.

Conclusion
Migraine and anxiety disorders have negative impacts on PPS among patients with MDD. Integrating the treatment of migraine and anxiety disorders into the management of depression might help to improve PPS and the prognosis of MDD.
An uncommon long-term survival case of primary cardiac leiomyosarcoma
Authors: Glaoui Meriam , Benbrahim Zineb , Belbaraka Rhizlane , Naciri Sara , Errihani Hassan , Lescene Axel 
Published: November 2014

Abstract
Primary cardiac sarcoma is a rare aggressive entity. It constitutes the second most common type of primary cardiac neoplasms. Its management has largely been guided by small retrospective series with a median survival of 6 months. Here, we discuss a unique case of 8-year survival cardiac leiomyosarcoma managed by surgical and adjuvant therapy.
Inclusion relations for Bessel functions for domains bounded by conical domains
Authors: Ramachandran Chellakutti , Annamalai Srinivasan , Sivasubramanian Srikandan 
Published: November 2014

Abstract
In recent times, applications of Bessel differential equations have been effectively used in the theory of univalent functions. In this paper we study some subclasses of k-starlike functions, k-uniformly convex functions, and quasi-convex functions involving the Bessel function and derive their inclusion relationships. Further, certain integral preserving properties are also established with these classes. We remark here that k-starlike functions and k-uniformly convex functions are related to domains bounded by conical sections.

MSC:30C45, 30C50.
Compensation claims for chiropractic in Denmark and Norway 2004–2012
Authors: Jevne Jørgen , Hartvigsen Jan , Christensen Henrik Wulff 
Published: November 2014

Abstract
Background
Adverse events are commonly observed in all parts of health care and have been reported extensively following manual therapy, including chiropractic. The majority of reported adverse events following chiropractic care are mild, transitory and self-limiting. However, little is known about patient filed compensation claims related to the chiropractic consultation process. The aim of this study was to describe claims reported to the Danish Patient Compensation Association and the Norwegian System of Compensation to Patients related to chiropractic from 2004 to 2012.

Methods
All finalized compensation claims involving chiropractors reported to one of the two associations between 2004 and 2012 were assessed for age, gender, type of complaint, decisions and appeals. Descriptive statistics were used to describe the study population.

Results
338 claims were registered in Denmark and Norway between 2004 and 2012 of which 300 were included in the analysis. 41 (13.7%) were approved for financial compensation. The most frequent complaints were worsening of symptoms following treatment (n = 91, 30.3%), alleged disk herniations (n = 57, 19%) and cases with delayed referral (n = 46, 15.3%). A total financial payment of €2,305,757 (median payment €7,730) were distributed among the forty-one cases with complaints relating to a few cases of cervical artery dissection (n = 11, 5.7%) accounting for 88.7% of the total amount.

Conclusion
Chiropractors in Denmark and Norway received approximately one compensation claim per 100.000 consultations. The approval rate was low across the majority of complaint categories and lower than the approval rates for general practioners and physiotherapists. Many claims can probably be prevented if chiropractors would prioritize informing patients about the normal course of their complaint and normal benign reactions to treatment.
Insulin-like growth factor-I inhibition with pasireotide decreases cell proliferation and increases apoptosis in pre-malignant lesions of the breast: a phase 1 proof of principle trial
Authors: Singh Baljit , Smith Julia A , Axelrod Deborah M , Ameri Pietro , Levitt Heather , Danoff Ann , Lesser Martin , de Angelis Cristina , Illa-Bochaca Irineu , Lubitz Sara , Huberman Daniel , Darvishian Farbod , Kleinberg David L 
Published: November 2014

Abstract
Introduction
Estrogen inhibition is effective in preventing breast cancer in only up to 50% of women with precancerous lesions and many experience side effects that are poorly tolerated. As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and has other direct effects on mammary development and carcinogenesis, we hypothesized that IGF-I inhibition might provide a novel approach for breast cancer chemoprevention.

Methods
In total, 13 women with core breast biopsies diagnostic of atypical hyperplasia (AH) were treated for 10 days with pasireotide, a somatostatin analog which uniquely inhibits IGF-I action in the mammary gland. They then had excision biopsies. 12 patients also had proliferative lesions and one a ductal carcinoma in situ (DCIS). Primary outcomes were changes in cell proliferation and apoptosis after treatment. Expression of estrogen receptor (ER), progesterone receptor (PR), and phosphorylated Insulin-like growth factor I receptor (IGF-1R), protein kinase B (AKT) and extracellular signal-regulated kinases 1/2 (ERK1/2) were also assessed. Core and excision biopsies from 14 untreated patients served as non-blinded controls. Hyperglycemia and other side effects were carefully monitored.

Results
Pasireotide decreased proliferation and increased apoptosis in all AH (from 3.6 ± 2.6% to 1.3 ± 1.2% and from 0.3 ± 0.2% to 1.5 ± 1.6%, respectively) and proliferative lesions (from 3.8 ± 2.5% to 1.8 ± 1.8% and from 0.3 ± 0.2% to 1.3 ± 0.6%, respectively). The DCIS responded similarly. ER and PR were not affected by pasireotide, while IGF-1R, ERK1/2 and AKT phosphorylation decreased significantly. In contrast, tissue from untreated controls showed no change in cell proliferation or phosphorylation of IGF-1R, AKT or ERK 1/2. Mild to moderate hyperglycemia associated with reduced insulin levels was found. Glucose fell into the normal range after discontinuing treatment. Pasireotide was well tolerated and did not cause symptoms of estrogen deprivation.

Conclusions
IGF-I inhibition by pasireotide, acting through the IGF-1R, was associated with decreased proliferation and increased apoptosis in pre-malignant breast lesions and one DCIS. Assuming hyperglycemia can be controlled, these data suggest that inhibiting the IGF-I pathway may prove an effective alternative for breast cancer chemoprevention.

Trial registration
NCT01372644 Trial date: July 1, 2007.
Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation
Authors: Sieber Julia , Daridon Capucine , Fleischer Sarah J , Fleischer Vanessa , Hiepe Falk , Alexander Tobias , Heine Guido , Burmester Gerd R , Fillatreau Simon , Dörner Thomas 
Published: November 2014

Abstract
Introduction
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with a break in self-tolerance reflected by a production of antinuclear autoantibodies. Since autoantibody production can be activated via nucleic acid Toll-like receptor 9 (TLR9), the respective pathway has been implicated in the development of SLE and pathogenic B cell responses. However, the response of B cells from SLE patients to TLR9 stimulation remains incompletely characterized.

Methods
In the current study, the response of B cells from SLE patients and healthy donors upon TLR9 stimulation was analyzed in terms of proliferation and cytokine production and correlated with the lupus disease activity and anti-dsDNA titers.

Results
B cells from SLE patients showed a reduced response to TLR9 agonist compared to B cells from healthy donors in terms of proliferation and activation. B cells from SLE patients with higher disease activity produced less interleukin (IL)-6, IL-10, vascular endothelial growth factor, and IL-1ra than B cells from healthy donors. Further analyses revealed an inverse correlation of cytokines produced by TLR9-stimulated B cells with lupus disease activity and anti-dsDNA titer, respectively.

Conclusion
The capacity of B cells from lupus patients to produce cytokines upon TLR9 engagement becomes less efficient with increasing disease activity, suggesting that they either enter an exhausted state or become tolerant to TLR stimulation for cytokine production when disease worsens.
Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer
Authors: Sohal Sukhwinder Singh , Mahmood Malik Quasir , Walters Eugene Haydn 
Published: November 2014

AbstractUnfortunately, the research effort directed into chronic obstructive pulmonary disease (COPD) has been disproportionately weak compared to its social importance, and indeed it is the least researched of all common chronic conditions. Tobacco smoking is the major etiological factor. Only 25% of smokers will develop “classic” COPD; in these vulnerable individuals the progression of airways disease to symptomatic COPD occurs over two or more decades. We know surprisingly little about the pathobiology of COPD airway disease, though small airway fibrosis and obliteration are likely to be the main contributors to physiological airway dysfunction and these features occur earlier than any subsequent development of emphysema. One potential mechanism contributing to small airway fibrosis/obliteration and change in extracellular matrix (ECM) is epithelial mesenchymal transition (EMT), so called Type‐II EMT. When associated with angiogenesis (Type‐III EMT) it may well also be a link with the development of lung (airway) cancer which is closely associated with COPD. Active EMT in COPD may help to explain why lung cancer is so common in smokers and also the core pathophysiology of small airway fibrosis. Better understanding may lead to new markers for incipient neoplasia, and better preventive management of patients. There is serious need to understand key components of airway EMT in smokers and COPD, and to demarcate novel drug targets for the prevention of lung cancer and airway fibrosis, as well as better secondary management of COPD. Since over 90% of human cancer arises in epithelia and the involvement of EMT in all of these may be a central paradigm, insights gained in COPD may have important generalizable value.
Response of the mesosphere-thermosphere-ionosphere system to global change - CAWSES-II contribution
Authors: Laštovička Jan , Beig Gufran , Marsh Daniel R 
Published: November 2014

Abstract
Long-term trends in the mesosphere, thermosphere, and ionosphere are areas of research of increasing importance both because they are sensitive indicators of climatic change and because they affect satellite-based technologies which are increasingly important to modern life. Their study was an important part of CAWSES-II project, as they were a topic of Task Group 2 (TG-2) ‘How Will Geospace Respond to Changing Climate’. Three individual projects of TG-2 were focused on important problems in trend investigations. Significant progress was reached in several areas such as understanding and quantifying the role of stratospheric ozone changes in trends in the upper atmosphere, reaching reasonable agreement between observed and simulated trends in mesospheric temperatures and polar mesospheric clouds, or understanding of why the thermospheric density trends are much stronger under solar cycle minimum conditions. The TG-2 progress that is reviewed in this paper together with some results reached outside CAWSES-II so as to have the full context of progress in trends in the upper atmosphere and ionosphere.
The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor
Authors: Gazdhar Amiq , Grad Iwona , Tamò Luca , Gugger Mathias , Feki Anis , Geiser Thomas 
Published: November 2014

Abstract
Introduction
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible fibrotic lung disease, resulting in respiratory insufficiency and reduced survival. Pulmonary fibrosis is a result of repeated alveolar epithelial microinjuries, followed by abnormal regeneration and repair processes in the lung. Recently, stem cells and their secretome have been investigated as a novel therapeutic approach in pulmonary fibrosis. We evaluated the potential of induced pluripotent stem cells (iPSC) conditioned media (iPSC-cm) to regenerate and repair the alveolar epithelium in vitro and improve bleomycin induced lung injury in vivo.

Methods
IPSC-cm was collected from cultured iPSC derived from human foreskin fibroblasts and its biological effects on alveolar epithelial wound repair was studied in an alveolar wound healing assay in vitro. Furthermore, iPSC-cm was intratracheally instilled 7 days after bleomycin induced injury in the rat lungs and histologically and biochemically assessed 7 days after instillation.

Results
iPSC-cm increased alveolar epithelial wound repair in vitro compared with medium control. Intratracheal instillation of iPSC-cm in bleomycin-injured lungs reduced the collagen content and improved lung fibrosis in the rat lung in vivo. Profibrotic TGFbeta1 and α-smooth muscle actin (α-sma) expression were markedly reduced in the iPSC-cm treated group compared with control. Antifibrotic hepatocyte growth factor (HGF) was detected in iPSC-cm in biologically relevant levels, and specific inhibition of HGF in iPSC-cm attenuated the antifibrotic effect of iPSC-cm, indicating a central role of HGF in iPSC-cm.

Conclusion
iPSC-cm increased alveolar epithelial wound repair in vitro and attenuated bleomycin induced fibrosis in vivo, partially due to the presence of HGF and may represent a promising novel, cell free therapeutic option against lung injury and fibrosis.
Influence of Environmental Thermal Load on Functional Status of Gas Industry Outdoor Workers During Summer
Authors: Константинов  , Konstantinov Evgeniy , Афанасьева  , Afanaseva Rallema 
Published: November 2014

The article presents microclimate parameters registered on workplaces of gas industry outdoor workers during summer in
Astrakhan region as well as equations for calculation of external thermal load and for correlation relationship between
external thermal load and functional status of worker (with regard for age and weight). The paper shows dynamics of
thermal load on work-er’s body and health during a shift. Factor structure is defined for health characteristics bound to
high external temperature, activation of thermoregulation mechanisms, cardiovascular system, and exhaustion. Analysis
of health indexes dynamics gives basis for definition of preferable du-ties. According to workers and their functional state
assessment average air temperature of 35,3±3,3 °С is defined as unfavorable, 38,5±0,4 °С – as problematic. The most
preferable (71% of answers) shift schedule includes alternation of periods of work and rest (in the shade). Reduced shifts
and regulation of periods of work and rest are preferred by 14,6% working. Suggestions for improvement of hygienic and
ergonomic indexes of PPE are presented on the basis of the questionnaire.
Laser System of Aerosol Emissions Prevention
Authors: Веденин  , Vedenin Evgeniy , Чартий  , Chartiy Pavel , Шеманин  , Shemanin Valeriy 
Published: November 2014

Presented system simultaneously controls concentration and size distribution function of particles by means of twowave
laser sounding on the basis of spectral clarity method for increase of probability of aerosol emissions detection and
identification at early stages of formation. Due to the system’s operational algorithm its response time does not exceed 300
sec. Laser system of prevention of emissions above the allowable level over industrial facility allows to resolve two main
issues: prevention of environmental pollution and elimination of raw materials losses in the form of dust emissions carried
away into the atmosphere.
Libération ou autodestruction? Les ‘réalités’ fictionnelles dans Le Jour où Nina Simone a cessé de chanter
Authors: Calargé Carla 
Published: November 2014

Abstract
The critical reception of Darina Al-Joundi’s Le jour où Nina Simone a cessé de chanter has encouraged a reading of this literary work in a manner often centred around the issue of the (im)possibility of freedom for Middle-Eastern women. This article looks at the genre of the book in order to show how the systematic blurring of the boundaries between fiction and lived experience has fostered the formation of an orientalist discourse obsessed with the oppression of Arab women. The subsequent close reading of excerpts from the text will expose some of the narrative’s incoherence, which should have incited literary critics to explore aspects of the text’s subconscious. Thus, the article contends that Al-Joundi’s rebellion is rather about trauma and self-destructive behaviour than about liberation. As such, it can be considered as a wonderful example of the various defense mechanisms that an intelligent and sensitive young person can deploy to cope with war’s trauma and the fear of death.
La critique parue autour de Le Jour où Nina Simone a cessé de chanter de Darina Al-Joundi encourage une approche du texte invariablement articulée autour de la question de l’/la im/possibilité de la liberté de la femme lorsque celle-ci est originaire d’un pays du Moyen-Orient. Cet essai se penche dans un premier temps sur des considérations génériques de l’œuvre afin de montrer que le brouillage fréquent des frontières entre le vécu et la fiction participe d’un discours orientaliste obsédé par l’oppression de la femme arabe. Dans un deuxième temps, et à travers une étude serrée de certains passages du texte, cette étude cherche à souligner quelques-unes des nombreuses incohérences narratives qui auraient dû mettre les critiques sur des pistes de lecture en rapport avec l’inconscient du texte. En relevant des indices en rapport avec la théorie des comportements autodestructeurs de type indirect cet essai propose que le récit d’Al-Joundi est à lire plutôt comme une magnifique illustration des traumatismes de la guerre et des mécanismes de défense et d’adaptation qu’une personne intelligente et sensible déploie pour faire face à la peur de mourir et à l’horreur des massacres.
Ethics of intertextuality in Calixthe Beyala’s fiction
Authors: Cowan Hélène S. 
Published: November 2014

Abstract
This study analyses some of the ethical stakes surrounding the extreme intertextual practices that characterize the literary aesthetics of Franco-Cameroonian writer Calixthe Beyala. Such practices famously caused a French court to convict Beyala of ‘partial plagiarism’ on one occasion in the 1990s – for her novel Le petit prince de Belleville (1992). In another case analysed here, French literary critic Pierre Assouline claimed to have found evidence that Beyala’s novel Assèze l’Africaine (1994) contained passages plagiarized from Paule Constant’s novel White Spirit (1989). Constant did not press charges, choosing instead to write her own vitriolic novel about a Franco-African professor-plagiarist titled Confidence pour confidence (1998). This article analyses Beyala’s Assèze l’Africaine (1994), as well as her literary response to Constant, Amours sauvages (1999), in order to nuance the negative reception that Constant, Assouline and other rushed readers have reserved for Beyala’s extreme intertextual practices. This article argues that iterary imitation in Beyala’s two aforementioned novels can be read as an ethical gesture through which the writer highlights the interconnectedness of, and commonalities between, ex-colonized and ex-colonizers.
Cette étude analyse les enjeux éthiques des pratiques intertextuelles décelables dans l’oeuvre de la romancière franco-camerounaise Calixthe Beyala. Ces pratiques furent l’objet de la condamnation de Beyala pour ‘contrefaçon partielle’ pour son roman intitulé Le petit prince de Belleville (1992) dans les années 1990. Dans un autre cas de supposé plagiat qui fait l’objet de cet article, le critique littéraire Pierre Assouline informa l’écrivaine française Paule Constant qu’il détenait la preuve que Beyala avait plagié un roman de celle-ci, White Spirit (1989), dans le roman intitulé Assèze l’Africaine (1994). Au lieu de porter l’affaire devant le tribunal, Constant répondit à Beyala par roman interposé (Confidence pour confidence (1998)). A travers l’analyse de deux romans de Beyala, Assèze l’Africaine (1994) et Amours sauvages (1999), ce dernier constituant la propre réponse de Beyala au roman-réponse de Constant déjà mentionné, cet article se propose de nuancer la réception négative que Constant, Assouline et autres lecteurs pressés réservèrent aux pratiques intertextuelles extrêmes de Beyala dans les romans en question. En fait, cet article défend l’idée que l’imitation littéraire dans ces oeuvres peut se lire comme un geste éthique par lequel la romancière souligne les liens partagés par les anciens colonisateurs et colonisés, et leurs descendants respectifs.
Governmental corruption through the Egyptian bloggers’ lens: A qualitative study of four Egyptian political blogs
Authors: El-Nawawy Mohammed , Khamis Sahar 
Published: November 2014

Abstract
Corruption was among the most serious problems under the rule of ousted Egyptian President Hosni Mubarak. Egyptian political bloggers played a critical role in reporting about the regime’s corrupt policies which were among the main factors behind the 2011 Revolution. This study analysed a number of threads selected from four prominent Egyptian political blogs that dealt with the issue of corruption. The analysed threads were divided into three main categories based on the primary function they attempted to perform: public mobilization, documentation or deliberation. Findings showed that political bloggers have played a critical role in enriching, revitalizing and mobilizing the Egyptian civil society, particularly in the prelude to the 25 January Egyptian Revolution. Still, this study showed that the role played by digital media platforms, such as political blogs, in promoting civic engagement, boosting democratization, and aiding political change should not be exaggerated or overstated. In other words, there has to be caution in assessing these new media technologies’ potential impact on reshaping the process of communication and democratization in the age of cyberspace.