bluuebunny/crossref_metadata_2025_split huggingface dataset:
Si⋅⋅⋅H Interligand Interactions in Cobalt(V) and Iridium(V) Bis(silyl)bis(hydride) Complexes
Authors: Horbatenko Yevhen , Vyboishchikov Sergei F. 
Published: July 2013

AbstractA series of bis(silyl)bis(hydride) cobalt complexes [Cp*Co(H)2(SiR3)2] (Cp*=pentamethylcyclopentadienyl; SiR3=SiPh2H, SiMe3, SiH3, SiF3, SiCl3, SiBr3, Si(CF3)3; Co1–Co7) as well as the analogous iridium complexes [Cp*Ir(H)2(SiR3)2] (SiR3=SiEt3, SiMe3, SiH3, SiF3, SiCl3, SiBr3, Si(CF3)3; Ir1–Ir7) were studied to detect possible residual Si⋅⋅⋅H interactions. Tests of several density functionals by comparison with coupled‐cluster results indicate that the TPSSh functional performs better than B3LYP, BP86, M06, M06L, and PBEPBE. Based on molecular structures, as well as Wiberg bond indices and J(Si,H) spin–spin coupling constants as indicators of a possible Si⋅⋅⋅H interaction, at least two residual Si⋅⋅⋅H interactions in Co2, Co5, and all four possible Si⋅⋅⋅H interactions in Co3 and Co4 have been detected. Co6 and Co7 exhibit stronger Si⋅⋅⋅H bonding than the other complexes studied. On the contrary, the iridium complexes Ir1–Ir3 and Ir5–Ir7 are classical iridium(V) bis(silyl)bis(hydride) complexes with only rudimentary Si⋅⋅⋅H interactions, if any.
Cogging Torque Characteristics of a Magnetic‐Geared Motor
Authors: Niguchi Noboru , Hirata Katsuhiro 
Published: July 2013

SummaryThis paper describes the cogging torque characteristics of a magnetic‐geared motor with permanent magnets only on the high‐speed rotor. The operational principle, which is different from that of the magnetic‐geared motor with permanent magnets on the high‐speed rotor and stator, is described. The torque characteristics, especially the order of the cogging torque, are mathematically formulated and verified by conducting 3D finite element analysis and carrying out measurements on a prototype. A novel cogging torque reduction method is proposed and verified as well.
Effect of Hydrogen and Oxygen Evolution Cocatalysts on Photocatalytic Activity of GaN:ZnO
Authors: Xiong Anke , Yoshinaga Taizo , Ikeda Takahiro , Takashima Masaki , Hisatomi Takashi , Maeda Kazuhiko , Setoyama Toru , Teranishi Toshiharu , Domen Kazunari 
Published: July 2013

AbstractThe coloading effect of H2 and O2 evolution cocatalysts on the overall water splitting reaction was investigated using a solid solution of GaN and ZnO (hereafter termed GaN:ZnO) as a photocatalyst. GaN:ZnO was modified with nanoparticulate Mn3O4, RuO2, and IrO2 as O2 evolution cocatalysts and with core/shell‐type Rh/Cr2O3 composites as H2 evolution cocatalysts. The photocatalytic activity of the coloaded samples for overall water splitting was higher than that of the samples modified with either of the O2 or H2 evolution cocatalysts alone. The activity enhancement induced by coloading was comparable for the three O2 evolution cocatalysts investigated at the optimized loading amounts. Loading of a more efficient Rh/Cr2O3 cocatalyst prepared by adsorption of Rh nanoparticles further improved the photocatalytic activity. It was concluded that a simultaneous improvement in both oxidation and reduction reactions was effective at enhancing the photocatalytic activity of GaN:ZnO, whereas the reduction reactions limited the overall reaction rate of the coloaded system more significantly.
Direct Amidation of Amino Acid Derivatives Catalyzed by Arylboronic Acids: Applications in Dipeptide Synthesis
Authors: Liu Shouxin , Yang Yihua , Liu Xinwei , Ferdousi Farhana K. , Batsanov Andrei S. , Whiting Andrew 
Published: July 2013

AbstractThe direct amidation of amino acid derivatives catalyzed by arylboronic acids has been examined. The reaction was generally slow relative to simple amine‐carboxylic acid combinations though proceeded at 65–68 °C generally avoiding racemization. 3,4,5‐Trifluorophenylboronic and o‐nitrophenylboronic acids were found to be the best catalysts, though for slower dipeptide formations, high catalyst loadings were required and an interesting synergistic catalytic effect between two arylboronic acids was discovered.
Gabapentin‐induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain
Authors: Hooker B.A. , Tobon G. , Baker S.J. , Zhu C. , Hesterman J. , Schmidt K. , Rajagovindan R. , Chandran P. , Joshi S.K. , Bannon A.W. , Hoppin J. , Beaver J. , Fox G.B. , Day M. , Upadhyay J. 
Published: July 2013

AbstractBackgroundThe function of brain networks can be changed in a maladaptive manner in response to chronic neuropathic pain. Analgesics can reduce pain by acting on such networks via direct or indirect (peripheral or spinal) mechanisms. This investigation aimed to map gabapentin's pharmacodynamics (PD) in the rodent brain following induction of neuropathic pain in order to further understand its PD profile.MethodsPharmacological magnetic resonance imaging (phMRI) and a novel functional connectivity analysis procedure were performed following vehicle or gabapentin treatment in the rat spinal nerve ligation (SNL) model of neuropathic pain as well as sham animals.ResultsphMRI performed in SNL animals revealed robust gabapentin‐induced responses throughout the hippocampal formation, yet significant (p < 0.05, corrected for multiple comparisons) responses were also measured in other limbic structures and the sensorimotor system. In comparison, sham animals displayed weaker and less widespread phMRI signal changes subsequent to gabapentin treatment. Next, communities of networks possessing strong functional connectivity were elucidated in vehicle‐treated SNL and sham animals. We observed that SNL and sham animals possessed distinct functional connectivity signatures. When measuring how gabapentin altered the behaviour of the discovered networks, a decrease in functional connectivity driven by gabapentin was not only observed, but the magnitude of this PD effect was greater in SNL animals.ConclusionsUsing phMRI and functional connectivity analysis approaches, the PD effects of gabapentin in a preclinical neuropathic pain state were characterized. Furthermore, the current results offer insights on which brain systems gabapentin directly or indirectly acts upon.
Nanoprofiles evaluation of ZnO thin films by an evanescent light method
Authors: Mirchin Nina , Peled Aaron , Duta Liviu , Popescu Andrei C. , Dorcioman Gabriela , Mihailescu Ion N. 
Published: July 2013

ABSTRACTThe extraction efficiency of evanescent light from ZnO nanolayers and their thickness profiles in the range of (1–105) nm was evaluated by a new microscopy technique, differential evanescent light intensity imaging method. It is based on capturing the evanescent light scattered by the layer of the material deposited on glass substrates. The analyzed ZnO films were obtained by pulsed laser deposition at 27°C and 100°C, using a nanosecond UV laser source. Microsc. Res. Tech., 76:992–996, 2013. © 2013 Wiley Periodicals, Inc.
Autofluorescence removal using a customized filter set
Authors: Pang Zhengyu , barash Eugene , Santamaria‐Pang Alberto , Sevinsky Christopher , Li Qing , Ginty Fiona 
Published: July 2013

ABSTRACTQuantitative fluorescence microscopy is severely hindered by intrinsic autofluorescence (AF). Endogenous fluorescent molecules in tissue and cell samples emit fluorescence that often dominates signals from specific dyes. This makes AF removal critical to the development and practice of quantitative fluorescence microscopy. In this study, we showed that AF signal could be separated from specific signal using a customized filter set. The filter set used the same excitation and beam splitter as the standard filter set, but the emission filter was red‐shifted 40–60 nm from the peak of the specific dye. This filter set configuration collected mostly AF with minimum contribution from the specific dye. A linear transformation of AF images was required to correct for the difference in exposure and filter configuration. The constants (slope and intercept) in linear transformation were obtained through a pixel to pixel comparison between AF images (no staining) obtained by the standard filter set and the customized AF filter set. After staining of specific dye, the standard filter collecting target dye spectra was used to capture both target signal and AF, whereas customized filter was used to capture only AF. AF removal was accomplished by subtracting the linear transformed AF image from the image obtained from the standard filter. To validate our approach, we examined weak staining of androgen receptor in an AF abundant prostate tissue sample. Our method revealed a similar but cleaner nuclear staining of androgen receptor in a specimen, when compared to a traditional autofluorescence removal method. Microsc. Res. Tech., 76:1007–1015, 2013. © 2013 Wiley Periodicals, Inc.
Anatomical and scanning electron microscopic characteristics of the tongue in the pampas deer (Cervidae: Ozotoceros bezoarticus, Linnaeus 1758)
Authors: Erdoğan Serkan , Pérez William 
Published: July 2013

ABSTRACTThis study represents the first definitive anatomical description of the tongue and lingual papillae of the pampas deer and compares the different information on the morphology of the other ruminant species available in the literature. In this study, the tongues of four adult and one fetal deer were used. The tongue was elongated with an oval or rounded apex. The filiform papillae on the lingual apex were smaller than the ones on the dorsal and lateral surfaces of the lingual body. Two very thin secondary papillary projections were found to emerge from the bilateral sides of some filiform papillae. Spherical fungiform papillae were randomly distributed among filiform papillae on dorsal surface of the lingual body and ventral surface of the apex. More developed conical papillae were observed in the caudal half of the lingual torus, whereas the rostral half of the torus had smaller conical papillae. Each conical papilla included shallow longitudinal groove on its anterior surface and some conical papillae on the lingual torus had bifid sharp apices. On the caudal portion of the torus, we also observed a few fungiform papillae, which were larger than those located on the lingual body. There were no lenticular papillae on the lingual torus, and five to nine round or oval circumvallate papillae were situated on each caudolateral side of the lingual torus. Morphological features of the tongue in the pampas deer were more similar to wild ruminant species than they were to domestic species. Microsc. Res. Tech., 76:1025–1034, 2013. © 2013 Wiley Periodicals, Inc.
Cloud optical and microphysical properties derived from ground‐based and satellite sensors over a site in the Yangtze Delta region
Authors: Liu Jianjun , Li Zhanqing , Zheng Youfei , Chiu J. Christine , Zhao Fengsheng , Cadeddu Maria , Weng Fuzhong , Cribb Maureen 
Published: July 2013

AbstractComprehensive surface‐based retrievals of cloud optical and microphysical properties were made at Taihu, a highly polluted site in the central Yangtze Delta region, during a research campaign from May 2008 to December 2009. Cloud optical depth (COD), effective radius (Re), and liquid water path (LWP) were retrieved from measurements made with a suite of ground‐based and spaceborne instruments, including an Analytical Spectral Devices spectroradiometer, a multifilter rotating shadowband radiometer, a multichannel microwave radiometer profiler, and the Moderate Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua satellites. Retrievals from zenith radiance measurements capture better the temporal variation of cloud properties than do retrievals from hemispherical fluxes. Annual mean LWP, COD, and Re are 115.8 ± 90.8 g/m2, 28.5 ± 19.2, and 6.9 ± 4.2 µm. Over 90% of LWP values are less than 250 g/m2. Most of the COD values (>90%) fall between 5 and 60, and ~80% of Re values are less than 10 µm. Maximum (minimum) values of LWP and Re occur in summer (winter); COD is highest in winter and spring. Raining and nonraining clouds have significant differences in LWP, COD, and Re. Rainfall frequency is best correlated with LWP, followed by COD and Re. Cloud properties retrieved from multiple ground‐based instruments are also compared with those from satellite retrievals. On average, relative to surface retrievals, mean differences of satellite retrievals in cloud LWP, COD, and Re were −33.6 g/m2 (−26.4%), −5.8 (−31.4%), and 2.9 µm (29.3%) for 11 MODIS‐Terra overpasses and −43.3 g/m2 (−22.3%), −3.0 (−10.0%), and −1.3 µm (−12.0%) for 8 MODIS‐Aqua overpasses, respectively. These discrepancies indicate that MODIS cloud products still suffer from large uncertainties in this region.
Communicate, don't litigate: The Schwartz Center Connections Program
Authors: Lown Beth A. , Gareis Karen , Kormos William , Kriegel Gila , Leffler Daniel , Richter Jim , Ship Amy , Weil Eric , Manning Colleen 
Published: July 2013

AbstractLittle is known about effective educational approaches intended to reduce malpractice risk by improving communication with patients and among multidisciplinary teams in outpatient settings in order to prevent diagnostic delays and errors. This article discusses a prospective, controlled educational intervention that aimed to open lines of communication among teams in two disciplines: identifying how and why communication lapses occur between disciplines and with patients, and articulating strategies to avert them.
Automated, wireless, continuous, intelligent, and noninvasive systems for risk management and performance improvement in vital signs monitoring
Authors: Bauer Jeffrey C. 
Published: July 2013

AbstractFew health professionals need to stay up‐to‐date on as many different problems and solutions as risk managers do. Consequently, a single solution that resolves several problems at once is really helpful for job performance, especially when it doesn't require duplicating effort in multiple areas. This article summarizes current literature about one such technology that helps risk managers address 3 of today's biggest challenges for healthcare delivery organizations: reducing costs, improving quality, and preventing harm across the continuum of clinical care; ensuring valid and reliable data for healthcare clinical and managerial decision makers; and adopting technologies that improve the medical marketplace.
Why are autopsy rates low in Japan? Views of ordinary citizens and doctors in the case of unexpected patient death and medical error
Authors: Maeda Shoichi , Kamishiraki Etsuko , Starkey Jay , Ikeda Noriaki 
Published: July 2013

AbstractThis article examines what could account for the low autopsy rate in Japan based on the findings from an anonymous, self‐administered, structured questionnaire that was given to a sample population of the general public and physicians in Japan. The general public and physicians indicated that autopsy may not be carried out because: (1) conducting an autopsy might result in the accusation that patient death was caused by a medical error even when there was no error (50.4% vs. 13.1%, respectively), (2) suggesting an autopsy makes the families suspicious of a medical error even when there was none (61.0% vs. 19.1%, respectively), (3) families do not want the body to be damaged by autopsy (81.6% vs. 87.3%, respectively), and (4) families do not want to make the patient suffer any more in addition to what he/she has already endured (61.8% vs. 87.1%, respectively).
Molecular epidemiology of rubella viruses involved in congenital rubella infections in São Paulo, Brazil, between 1996 and 2009
Authors: Curti Suely Pires , Figueiredo Cristina Adelaide , de Oliveira Maria Isabel , Andrade Joelma Queiroz , Zugaib Marcelo , Frugis Yu Ana Lucia , Oliveira Danielle Bruna , Durigon Edison Luiz 
Published: July 2013

AbstractRubella virus (RV) infection during the early stages of pregnancy can lead to serious birth defects, known as congenital rubella syndrome (CRS). This retrospective study was conducted between 1996 and 2009 with surveillance specimens collected from patients suspected of congenital rubella infection (CRI) and CRS. The clinical samples (nine amminiotic fluid, eight urine, eight blood, one conception product, and one placenta) were sent for viral isolation and genotyping. Twenty‐seven sequences were analysed and four genotypes (1a, 1B, 1G, and 2B) were identified in São Paulo that were involved in congenital infection. To our knowledge, this study is the first report that describes genetic diversity of the circulating rubella strains involved in CRI. J Med. Virol. 85:2034–2041, 2013. © 2013 Wiley Periodicals, Inc.
Decreased expression of microRNA‐625 is associated with tumor metastasis and poor prognosis in patients with colorectal cancer
Authors: Lou Xiaolou , Qi Xiaoliang , Zhang Yong , Long Houdong , Yang Jianjun 
Published: July 2013

AbstractBackgroundMicroRNAs (miRNAs) play an essential role in colorectal cancer (CRC) development and progression. Aberrant miR‐625 expression has been reported in several cancers. However, the clinical significance of miR‐625 in human CRC has not been addressed.MethodsmiR‐625 expression was determined in 96 pairs of primary CRC and their corresponding adjacent nontumor tissues by quantitative reverse transcriptase‐polymerase chain reaction. Associations of miR‐625 expression with demographic and clinicopathologic features were determined. Additionally, the effects of ectopic expression of miR‐625 on cell migration and invasion were investigated in vitro and in vivo.ResultsmiR‐625 was significantly downregulated in CRC tissues and cell lines. In addition, the decreased expression of miR‐625 was positively associated with advanced lymph node metastasis (P = 0.038), liver metastasis (P = 0.031), poor overall survival (P = 0.002), and an unfavorable prognosis for CRC patients, as determined through a multivariate analysis (P = 0.034). Moreover, functional assays demonstrated that ectopic miR‐625 expression inhibits the invasion and migration of HCT116 CRC cells both in vitro and in vivo.ConclusionsOur results suggest that miR‐625 may serve as an efficient clinical biomarker and a therapeutic tool for the inhibition of metastasis in CRC. J. Surg. Oncol. 2013 108:230–235. © 2013 Wiley Periodicals, Inc.
Facile One‐Step Synthesis of Monodisperse Micron‐Sized Latex Particles with Highly Carboxylated Surfaces
Authors: Appel Jeroen , Akerboom Sabine , Fokkink Remco G. , Sprakel Joris 
Published: July 2013

A facile method for the aqueous synthesis of monodisperse and micronmeter‐sized colloids with highly carboxylated surfaces is presented. The method is applied to three different monomers, styrene, methyl methacrylate, and 2,2,2‐trifluoroethyl methacrylate, and illustrate tuning of the size and monodispersity in the reactions. High surface density of carboxylic acids of up to 10 COOH nm−2 from potentiometric titrations, is achieved through copolymerization with itaconic acid. The versatility of this system is highlighted by creating highly fluorescent and monodisperse particles that can be index matched in aqueous solution and through surface modification via the carboxylic acid groups using standard amidation chemistry.
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Lidamycin inhibits tumor initiating cells of hepatocellular carcinoma Huh7 through GSK3β/β‐catenin pathway
Authors: Chen Yi , Yu Dongke , Zhang Caixia , Shang Boyang , He Hongwei , Chen Jinjing , Zhang Hao , Zhao Wuli , Wang Zhen , Xu Xiaoyu , Zhen Yongsu , Shao Rong‐guang 
Published: July 2013

AbstractRecently, tumor initiating cells are considered as the central role of tumorigenicity in hepatocellular carcinoma. Enediyne anticancer antibiotic lidamycin with great potential antitumor activity is currently evaluated in Phase II clinical trials. In this study, we evaluated the effect of lidamycin on tumor initiating cells of hepatocellular carcinoma Huh7 and identified the potential mechanism. Flow cytometry analysis and sorting assay, surface marker assay, sphere formation assay, and aldefluor assay were used to evaluate the effect of lidamycin on Huh7 tumor initiating cells in vitro. To investigate the potential mechanism, the activity of GSK3β/β‐catenin pathway was detected by Western blot and T cell factors transcriptional activity assay. Subcutaneous tumor model in nude mice was used to observe in vivo effect of lidamycin on Huh7 cells. Lidamycin decreased the proportion of EpCAM+ cells and the expression of EpCAM protein. Lidamycin inhibited sphere formation of sorted EpCAM+ cells in 7 d, and of parental cells in three serial passages. The population of aldehyde dehydrogenase‐positive cells was reduced by lidamycin. In addition, lidamycin restrained tumor volume and incidence in vivo. Lidamycin activated GSK3β, and degraded the activity of β‐catenin. Consequently, transcriptional activity of β‐catenin/T cell factors was decreased. In brief, these results suggest that lidamycin suppressed Huh7 tumor initiating cells via GSK3β/β‐catenin pathway. These findings reveal the potential mechanism of lidamycin on tumor initiating cells and the benefit for further clinical evaluation. © 2013 Wiley Periodicals, Inc.
Sensorimotor adaptation of speech in Parkinson's disease
Authors: Mollaei Fatemeh , Shiller Douglas M. , Gracco Vincent L. 
Published: July 2013

ABSTRACTThe basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society