bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-Ictal Mania: A Case Report with Literature Revue
Authors: Haouari W. , Omri S. , Labyadh A. , Feki R. , Gassara I. , Smaoui N. , Ben Thabet J. , Maalej M. B. , Maalej M. , Charfi N. , Zouari L. 
Published: August 2024

IntroductionWhile postictal mania is a well-recognized clinical condition, it has received less research attention compared to other postictal manifestations.ObjectivesDrawing upon an analysis of a case report that underscores the clinical and therapeutic challenges associated with comorbid epilepsy and mania, a literature review was carried out to investigate the connection between these two disorders.MethodsWe illustrate a case of comorbidity between mania and epilepsy and provide a concise review of the literature summarizing the key characteristics of this association.ResultsThis case pertains to Mr. M, a 44-year-old male with a history of frontal epilepsy characterized by secondary partial generalization, which was partially controlled with sodium valproate. He was admitted to our service due to acute agitation following a loss of consciousness lasting a few minutes.Upon admission, the patient exhibited symptoms of mental confusion. A neurological examination did not uncover any abnormalities. Brain computed tomography revealed mild frontal atrophy. Video electroencephalography conducted during the interictal period and outside the episodes of confusion did not reveal any abnormalities. The patient was restarted on sodium valproate (20 mg/kg/day) and clonazepam (2 mg/day). Following a lucid interval of ten days, the patient started to manifest psychiatric symptoms, which included irritability, hostility towards his spouse, increased talkativeness, thought pressure, and an unusual sense of familiarity, raising suspicion of post-ictal mania.ConclusionsBased on this clinical case and the existing scientific literature, post-ictal mania occupies a distinct position among the mental disorders observed in the post-ictal period. Therefore, clinicians must be aware of these conditions to facilitate accurate diagnosis and appropriate management.Disclosure of InterestNone Declared
Development and Validation of the Isotretinoin Hesitancy Scale
Authors: Agaoglu E. , Yilmaz-Karaman I. G. , Yastibas-Kacar C. , Kaya-Erdogan H. , Mutlu T. , Acer E. 
Published: August 2024

IntroductionIsotretinoin is an effective treatment for acne vulgaris; however, many patients experience anxiety while deciding to get it. Isotretinoin, indeed, has significant adverse effects. On the other hand, effective treatment of acne vulgaris may reduce dermatological and psychiatric complications.ObjectivesThe present study aims to develop and validate the Isotretionin Hesitancy Scale to measure the patients’ drawbacks to the treatment.MethodsThe specialists, including dermatologists and mental health professionals, determined an item pool of 30 items. Before the data collection, all items were checked by the researchers in terms of clarity and acceptability. Thus, the eight items were removed from the questionnaire due to having similar meanings, measuring the facts about treatments that are not the study’s objective, and containing unclear statements. The final version of the questionnaire, which consists of 22 items, was applied to the participants.ResultsOne hundred patients with acne vulgaris were recruited. Among the participants, 72% were women, and the mean age was 22.72. Most patients’ acne severity was group 2 (40%) and group 3 (36%). Three items were removed because of having low item-total score correlations. Five items were removed in factor analysis because of low factor loading or cross-loading. Exploratory factor analysis results of the scale are presented in Table 1.
Table 1.Exploratory Factor Analysis Results of the Scale
Factor 1(min-max)
Factor 2(min-max)
Factor 3(min-max)Isotretinoin treatment can lead to dryness of lips, nose, and eyes.Isotretinoin treatment may have many side effects.Isotretinoin treatment may cause damage to the liver.Side effects of isotretinoin treatment may affect my daily life.Isotretinoin treatment may cause depression.Isotretinoin treatment may cause elevation of cholesterol level.0.516-0.842Isotretinoin treatment may cause infertility in men.Isotretinoin treatment may cause infertility in women.Isotretinoin treatment may prevent height gain.In case of pregnancy, isotretinoin treatment may cause congenital defects in the baby.0.425-0.945I’m afraid of using isotretinoin for a long period.I stop the isotretinoin treatment as soon as possible.I will wait as long as I can before using isotretinoin treatment.I need more reassurance about isotretinoin treatment.0.569-0.890The Cronbach alpha score of the final form of the scale was found to be .81, the internal consistency of the first factor (hesitancy related to reversible adverse effects) was calculated as .79, the second factor (hesitancy related to irreversible adverse effects) was calculated as .78, and the final factor (isotretinoin-related anxiety) was found to be .72.ConclusionsThe Isotretionin Hesitancy Scale is valid and reliable among patients with acne vulgaris.Disclosure of InterestNone Declared
Case-based Workshop: Presentation of offenders with intellectual disabilities: towards an open and inclusive treatment
Authors: Saeedzadeh Sardahaee F. 
Published: August 2024

AbstractLegal frameworks and the challenges for treatment and rehabilitation of offenders with intellectual disabilities Speaker: Farzaneh Saeedzadeh Sardahaee, MD, PhD, Consultant psychiatrist St. Olav University Hospital, Trondheim, NorwayLack of timely diagnostic and treatment for mild intellectual disability amongst offenders presents special challenges to clinicians and prison system alike. On the one hand, appropriate treatment for their psychiatric symptoms may not be implemented as they can be mislabeled primarily as behavioral issues. Different approaches to such perceived behavioral issues within judiciary (or prison) system and health care system is a potential conflict area. On the other hand, treatment and rehabilitation of offenders with intellectual disability require both resources and expertise that may not be readily available in prison systems, pre- or past sentencing. Furthermore, the scope of such challenges varies greatly based on different legal frameworks for sentencing offenders with intellectual disability within Europe.In the first section an overview of Norwegian legal framework for offenders with intellectual disability is briefly presented. Then using the example of a young female offender with mild intellectual disability, drug dependence and multiple psychiatric morbidities, the speaker examines complexities of dual diagnoses, inter-disciplinary and multiagency cooperation follow-up and challenges faced in the recovery process. A brief introduction to the current Norwegian follow-up system for offenders with intellectual disability is discussed before examining recent changes in legal framework for sentencing offenders with intellectual disability in Norway, and its ramifications, as well as potential benefits for treatment and future rehabilitation of offenders. Finally, the speaker reflects on points for further improvement, especially considering the multi-agency nature of treatment and rehabilitation of offenders with intellectual disability.Disclosure of InterestNone Declared
Impact of the Second Wave of the COVID-19 Pandemic on the Quality of Life and Emotional Well-being of Students studying humanities disciplines in Russia
Authors: Rozhdestvenskiy V. I. , Titova V. V. , Gorkovaya I. A. , Ivanov D. O. , Aleksandrovich Y. S. 
Published: August 2024

IntroductionThe second wave of the COVID-19 pandemic had a significant impact on the quality of life and emotional well-being of the Russian population, with increased emotional disorders such as depression and anxiety. This study focuses on the specific context of Russian university students studying humanities disciplines, who had to adapt to remote learning and self-education during the pandemic.ObjectivesThis study aimed to assess the quality of life and measure the levels of depression, anxiety, and stress among Russian humanities students. Additionally, it examined the correlations between quality of life and emotional disorders.MethodsData collection was conducted between January and April 2021 using a customized Google form. The study included 35 students from Russian universities. Quality of life was assessed using the WHOQOL-BREF questionnaire, and levels of depression, anxiety, and stress were determined using the DASS-21 methodology, both adapted for use in Russia.ResultsThe mean values for the quality of life domains were as follows: “physical and psychological well-being” (M = 20.65±3.85), “self-image” (M = 19.21±3.54), “microsocial support” (M = 10.39±2.36), and “social well-being” (M = 27.93±4.15). Notably, 54% of respondents exhibited no symptoms of depression, 66% showed no signs of anxiety, and 69% reported no stress. Correlation analysis revealed that there was no statistically significant relationship between stress and quality of life, and social well-being did not correlate with emotional disturbances.ConclusionsDuring the second wave of the COVID-19 pandemic, the majority of Russian humanities students did not experience clinical manifestations of depression, anxiety, or stress. To improve their emotional well-being, students should prioritize their physical and psychological health, self-perception, self-esteem, and relationships with their immediate social circles, particularly their families. In this pandemic context, broader social factors such as recreational opportunities took a back seat in students’ priorities.Disclosure of InterestNone Declared
Fundamental beliefs, as well as levels of depression, anxiety, and stress experienced by Russian students during the second wave of the COVID-19 pandemic
Authors: Rozhdestvenskiy V. I. , Titova V. V. , Gorkovaya I. A. , Ivanov D. O. , Aleksandrovich Y. S. 
Published: August 2024

IntroductionA pandemic caused by a novel coronavirus is an immensely traumatic event. Researches indicate that such events significantly impact various aspects of individuals, including their physical, emotional, cognitive, behavioural, and social functions, affecting different components of their personality structure. However, the experience of trauma itself is influenced by implicit internal structures known as underlying beliefs. Consequently, emotional responses to traumatic events may be interconnected with these core beliefs.Objectives
This study aimed to explore fundamental beliefs among Russian university students and analyze their associations with emotional reactions such as depression, anxiety, and stress.MethodsData collection took place from January to April 2021 using a custom-designed Google form. The study involved 35 Russian university students. We employed the WAS-37 methodology to investigate fundamental beliefs and the DASS-21 methodology to assess the levels of depression, anxiety, and stress. Both questionnaires were adapted for use in Russia.Results
We found that the mean values of the “Benevolence of the surrounding world” (M = 35.5±7.3) and “Luck” (M = 31.7±5.1) scales are higher than the normative mean values for the Russian population. In contrast, the mean values of the “Fairness” (M = 21.0±3.7), “Self-image” (M = 26.6±7.0) and “Beliefs about control” (M = 26.6±4.8) scales are generally not different from the normative values. Depression has negative correlations with Self-image (rs = -0.590, p < 0.01) and Beliefs about control (rs = -0.509, p < 0.01). No statistically significant correlations of anxiety and stress with baseline beliefs were obtained.ConclusionsDuring the second wave of the pandemic, Russian university students tend to view the world around them as less perilous than the broader population does, and they perceive themselves as more fortunate. Depressive feelings among students are linked to their lower beliefs in the value and importance of their self, as well as their perception that the world around them is not sufficiently controllable.Disclosure of InterestNone Declared
Multifaceted Impact of the COVID-19 Pandemic and Lockdown on Physical and Mental Health: Insights from a Cross-Sectional Study
Authors: Dimitriou V. , Kalogirou C. , Potamianou A. , Bakola M. , Gourzis P. , Charalampous G. , Jelastopulu E. 
Published: August 2024

IntroductionThe global COVID-19 pandemic and subsequent lockdowns have significantly impacted global wellbeing and highlighted the close link between mental and physical health. Social isolation and quarantine have proven to be major stressors, leading to emotional distress and unpredictable psychological consequences.ObjectivesWe explored the pandemic’s impact on individuals’ physical and mental health and social relationships.MethodsWe conducted a cross-sectional study using a questionnaire which included among other socio-democratic questions, the Fear of COVID-19 Scale, the World Health Organization Quality-of-Life Scale (WHOQOL-BREF) and the Toronto Empathy Questionnaire (TEQ).ResultsA total of 511 adults (55.1% males) participated in this study. Participants reported increased social media use (more than 4-5 times/week) during the lockdown, which was associated with increased fear of COVID-19 and negative effects on mental and physical health, and social relationships (p<0.01). Conversely, non-work-related outings (once a week) were associated with lower fear (p<0.01) and better well-being (p<0.05). Higher fear, particularly for loved ones, was associated with negative effects. The level of physical health was moderate to high, with varying levels of satisfaction in different areas. Empathy correlated with increased fear (p<0.01) and reduced mobility (p<0.05).ConclusionsThe COVID-19 pandemic and lockdowns significantly affected physical and mental health, highlighting the importance of tailoring interventions for vulnerable populations and promoting adaptive coping strategies in times of crisis.Disclosure of InterestNone Declared
Tardive Dysphoria: can antidepressants cause depression?
Authors: Desport C. P. , Martins D. O. , Freitas J. R. , Santos M. F. , de Castro L. C. 
Published: August 2024

Introductiontardive dysphoria is a relatively new term used to describe the phenomenon of clinical worsening of depression after long-term antidepressant use. Most of the theories proposed to explain this talk about antidepressants tachyphylaxis that implies the loss of efficacy with its prolonged use, or even a pro-depressant effect of antidepressants when used for long periods of time.Objectivesto explore the concept of tardive dysphoria, potential causes and clinical implications, by making a literature review on the topic. Moreover we pretend to understand the challenges in its diagnosis and treatment.Methodsbibliographical search in PubMed database, using the key-words “long-term antidepressant”, “tardive dysphoria” and “antidepressant tachyphylaxis”, limited to works published in the last twenty years.Resultsfrom our search resulted 53 articles, 26 were chosen for further analysis.Conclusions
the concept of tardive dysphoria is controversial, namely doubt persists if it constitutes a clinical entity by itself caused by long-term antidepressant use or if it simply relates to cases of treatment-resistant depression. We conclude that it is necessary further investigation in this area given the significant implications on clinical practice specifically in the psychopharmacological treatment with antidepressants, which is very common in psychiatric and general practices, with antidepressants being used to treat many mental health conditions.Disclosure of InterestNone Declared
Unipolar and Bipolar Depressed Inpatients: correlations with Vitamin D and Cognitive Symptoms
Authors: Bonfitto I. , Moniello G. , Francavilla G. , Bellomo A. , Dimalta S. 
Published: August 2024

Introduction
Cognitive symptoms are the main factor of discomfort in depressed patients, persisting even during clinical remission (Conradi et al. Psychol Med 2011;41:1165-74) and inevitably compromising their quality of life (Fehnel et al. CNS Spectr 2013;25:1-10). Several studies have suggested the neuroprotective role of vitamin D, both through actions on the genome and rapid non-genomic mechanisms; so, low serum vitamin D levels are related to poorer cognitive performance (Goodwill et al. JAGS 2017;2:1-8), depressive disorders (Kjærgaard et al. Psyc Res 2011;190:221-225) and suicide risk (Umhau et al. PLoS One 2013;8:e51543).Objectivesto investigate relationships between serum vitamin D levels, depressive symptoms and cognitive performance in unipolar and bipolar depressed adults hospitalized for Major Depressive Episode (MDE).Methods80 patients (34 M and 46 F; average age 48,96±14,17 years; 40% with bipolar depression) were examined. Depression was investigated using Hamilton Rating Scale for Depression (HAM-D), while cognitive functions were explored by: Rey Auditory Verbal Learning Test (RAVLT) and Rey-Osterrieth Complex Figure (ROCF) to assess verbal and visuospatial memory, respectively; Trail Making Test (TMT) and Stroop Color and Word Test to assess attention, spatial planning and cognitive flexibility. Venous blood sampling was used to determine serum Vitamin D levels (average level 15,67 ± 8,7 ng/ml).Results
At first, the serum level of vitamin D was found to be inversely correlated with HAM-D scores (p=0,0079), so that lower concentrations of vitamin D is related to greater severity of depression. In addiction, there were strongly significative positive correlations between low vitamin D levels and poorer RAVLT and ROCF scores and strongly significative negative correlations between vitamin serum level and higher scores in TMT and STROOP test, so that calcidiol deficit is associated with poor cognitive performance. Similarly, patients with higher HAM-D scores were found to have a greater cognitive impairment (lower RAVLT e ROCF scores and higher TMT e STROOP scores).Conclusions
In accordance with previous works, our study supports the close relationship between serum vitamin D levels and depressive morbidity. During MDE hypovitaminosis D is related to worse disease indices, such as severity of affective symptoms and cognitive impairment, without substantial differences between clinical manifestations of unipolar and bipolar depression, both in terms of affective and cognitive symptoms and disease severity. Considering that cognitive deficits are truly disabling because they may resist to common antidepressant treatments and, as a result, persist during stages of clinical remission, vitamin d supplementation, by minimizing cognitive dysfunction, could be a good strategy to reduce the risk of relapses and to improve patients’ functioning and quality of life.Disclosure of InterestNone Declared
The opportunity for e-mental health to overcome stigma and discrimination
Authors: Subramaniam K. , Greenshaw A. , Thapliyal A. 
Published: August 2024

IntroductionMany with mental illness do not seek treatment, often due to stigma; be it public, self, or institutional type. To improve outcomes, stigma needs addressing.ObjectivesUnderstand the opportunity for e-mental health to help overcome stigma and, to provide an expert opinion to foster its adoption.MethodsWe conducted literature searches using the terms ((mental health) AND ((stigma) OR (discrimination))) AND (((((digital tools) OR (digital services)) OR (healthcare apps)) OR (digital solutions)) OR (digital technology)), limited to 2007 – 2023, identifying 223 citations, 9 of which were relevant for this evaluation, including 4 systematic reviews (
Table 1).ResultsLiterature reports suggest that e-mental health may be useful for addressing stigma and reducing the treatment gap. While it was not consistently as good as face-to-face services, e-mental health tools were frequently shown to be effective in reducing stigma, improving mental health literacy, and increasing help-seeking behaviors. Tools included web-based breathing, meditation, and CBT; suicide prevention apps; and online videos and games. Experts from a 2022 global Think Tank session convened by eMHIC, opined and emphasised that embracing e-mental health must not leave people behind nor reinforce inequality and that structural barriers must first be acknowledged and overcome. Creating a shared understanding of the challenge and of terminology is essential, as is codesigning any solution together with people with lived experience.
Table 1.Systematic literature reviewsStudyInterventionsFindingsSLR + meta-analysis, 9 studies, n=1916 (Goh et al. Int J Ment Health Nu 2021;30:1040–1056)-Web-based program-MIDonline-AboutFace-BluePages-MoodGYM-MHFA eLearning-Beyond SilenceOnline vs offline: similarly effective for reducing public stigmaSLR, healthcare setting (Pospos,et al. Acad Psychiatry 2018;42:109–120)-Breath2Relax-Headspace-Meditation Audios-MoodGYM-Stress Gym-Virtual Hope Box-Stay AliveIdentified tools provide a starting point to mitigate burnout, depression, and suicidalitySLR, 13 interventions for stigma (Johnson, et al. Indian J Psychol Med 2021;44:332–340)-Web-based, psychoeducation interventions-Online games-Mobile appMost interventions increased help-seeking
SLR + meta-analysis, 9 RCTs, n=1832 (Rodriguez-Rivas, et al. JMIR Serious Games. 2022; 10:e35099)-Video games-Virtual reality-Videoconferencing and online chatInterventions had a consistent effect on reducing public stigmaConclusionsPublished data suggest that e-mental health is promising to reduce stigma and discrimination, with the potential to foster help-seeking and treatment engagement. Adoption requires attention to derailers and must foster inclusivity. There is an imperative to adopt e-mental health, especially evidence-based solutions.Disclosure of InterestK. Subramaniam Employee of: Employee of Viatris, A. Greenshaw: None Declared, A. Thapliyal: None Declared
Randomized controlled trail of work-map: telehealth metacognitive intervention for work performance enhancement of adults with attention-deficit/hyperactivity disorder
Authors: Grinblat N. , Rosenblum S. 
Published: August 2024

IntroductionThe literature has emphasized the importance of implementing evidence-based occupational therapy teleinterventions to enhance work participation in adults with attention-deficit/hyperactivity disorder (ADHD).ObjectivesThis study aimed to evaluate the efficacy of an innovative metacognitive self-tailored teleintervention for adults with ADHD performance at work enhancement (Work-MAP). The outcome measures were efficacy of and satisfaction with the performance of self-selected work goals (Canadian Occupational Performance Measure), executive functions (Behavior Rating Inventory of Executive Function-Adult), and quality of life (Adult ADHD Quality of Life Questionnaire).MethodsIn this randomized controlled trial, participants were 46 adults with ADHD. Group A (n = 31) received the synchronous, hybrid-telehealth intervention in 11 weekly 1-hour individual sessions, while Group B (n = 15) completed the same intervention after a waiting phase.ResultsFollowing the intervention, participants demonstrated and maintained significant improvements in all outcome measures (strong-to-moderate significant effects) to the 3-month follow-up.ConclusionsWork-MAP seems to be effective intervention for enhancing work participation (i.e., performance at work), executive functions, and quality of life of adults with ADHD. Future studies with larger samples and additional objective measures are needed to further validate these findings.Disclosure of InterestNone Declared