bluuebunny/crossref_metadata_2025_split huggingface dataset:
Papular Acantholytic Dyskeratosis of the Genitalia
Authors: Lee Seung Hun , Jang Jin Gon 
Published: April 2015

AbstractA 32‐year‐old man presented with multiple papules on the pubic area for 5 months. There were no subjective symptoms. We could not find any clues for predisposing factors. Pathological examination of the excised papules revealed marked acantholysis and dyskeratosis in the epidermis. The lesions persisted for 5 months after the pathological examination. We consider the present case to be similar to that of Chorzelski et al., papular acantholytic dyskeratosis of the vulva, reported in 1984. We would like to propose this case as papular acantholytic dyskeratosis of the genitalia.
Cutaneous Mucinosis Associated with SLE
Authors: Nishimoto Masayoshi , Takaiwa Takashi , Kodama Hajime , Nohara Nozomi 
Published: April 2015

AbstractA patient with SLE which was complicated by a characteristic cutaneous mucinosis is reported. The skin lesions were composed of intradermal soft nodules, purple‐red plaques, and alopecia of the scalp. Acid mucopolysaccharides accumulated in each lesion. PUVA provoked an infiltrated skin lesion in which acid mucopolysacchraides were deposited in the dermis. Deposition of immunoglobulins and complements were also observed at the dermo‐epidermal junction and on the vascular walls. Some immunological processes which may stimulate the synthesis of acid mucopolysaccharides in the dermis were suggested.
Verruciform Xanthoma on the Scrotum
Authors: Nakamura Shin‐ichi , Kanamori Sachio , Nakayama Keiji , Aoki Masako 
Published: April 2015

AbstractA case of 80‐year‐old man with a verruciform xanthoma on the right side of the scrotum was reported. The tumor was examined histologically by light and electron microscope. We surveyed the literature and found 25 Japanese cases and 11 foreign cases in the skin. We also reviewed the pathogenesis and the location of this disease.
Cutaneous Polyarteritis Nodosa: A Clinical and Histopathological Study of 20 Cases
Authors: Chen Ko‐Ron 
Published: April 2015

AbstractTwenty cases diagnosed as cutaneous polyarteritis nodosa (CPN) and confirmed by skin biopsy over the last 17 years were reviewed in our department. Based upon their clinical features, laboratory findings, and long‐term observation of the disease course, they were divided into three groups.
Group 1 comprised 16 cases which were classified as the mild cutaneous form. The disease was confined to the skin with occasional involvement of peripheral nerves and skeletal muscles of the affected extremity. They generally followed a benign course.
Group 2 comprised 2 cases classified as the severe form. Despite severe clinical manifestations and several abnormal laboratory findings, the disease was limited to the skin, muscles, and peripheral nerves without any visceral involvement over follow‐up periods of 11 years and 5 years, respectively.
Group 3 comprised 2 cases of the progressive form; in these the disease had begun with a cutaneous lesion and progressed to the systemic form after 19 and 18 year periods of recurrent episodes of cutaneous lesions, respectively. One died of gastrointestinal bleeding. In group 3, serum antinuclear antibodies and rheumatoid factor were positive. The autoimmune mechanism seems to play a role in this group. It is clear from the results of this study that not all patients whose vasculitic lesions are apparently limited to the skin remain in a benign course. Long‐term follow‐up is essential.
Cutaneous Metastasis from Hepatocellular Carcinoma Resembling Granuloma Teleangiectaticum
Authors: Yamanishi Kiyofumi , Kishimoto Saburo , Hosokawa Yohei , Yamada Kazuo , Yasuno Hirokazu 
Published: April 2015

AbstractWe reported a case of cutaneous metastasis originated from hepatocellular carcinoma, which appeared as a nodule resembling granuloma teleangiectaticum. The nodule, which was composed of tumor cells and intervening capillaries, showed characteristics similar to those of primary hepatocellular carcinoma. On immunohistochemical staining, the tumor cells were positive not only for AFP (alpha‐fetoprotein), but also for CEA (carcinoembryonic antigen), which is negative in most cases of primary hepatocellular carcinoma. We discussed this case with a review of previous reports of skin metastasis from liver carcinoma.
A Case of Tick Bite with Ixodes turdus Nakatsuji
Authors: Woo In Cheol , Baba Shunichi , Suzuki Hiroyuki , Kawabata Masato 
Published: April 2015

AbstractThe first case of tick bite by Ixodes turdus Nakatsuji was reported. The tick was found on the occipital area near the left ear of a 6‐year‐old boy. The tick bite occurred in Hoya, a suburb of Tokyo.
Anticardiolipin Antibodies in Behçet's Disease
Authors: Bergman Reuven , Lorber Margalit , Lerner Marta , Brik Riva , Friedman‐Birnbaum Rachel 
Published: April 2015

AbstractTwenty‐six patients with Behçet's disease were studied for serum levels of anticardiolipin (ACL) antibody isotypes IgG and IgM. The frequency of elevated levels of ACL antibody isotype IgM was found to be significantly increased in these patients. This increased frequency, however, did not correlate statistically with a thrombotic tendency, colchicine intake, antinuclear antibodies, or a positive VDRL test.
An Epidermoid Cyst with a Seborrheic Verruca‐like Cyst Wall
Authors: Chun Soo Il , Im Sungbin 
Published: April 2015

AbstractThe epidermoid cyst with a seborrheic verruca‐like cyst wall is a newly described variant of the epidermoid cyst. The cyst wall of this variant shows changes simulating seborrheic keratosis and verruca. Our case of a subcutaneous mass was shown histopathologically to have this variant.
Localized Form of Multiple Glomus Tumors: Report of the First Case Showing Partial Involution
Authors: Kato Naoko , Kumakiri Masanobu , Ohkawara Akira 
Published: April 2015

AbstractWe recently examined a boy with relatively large multiple glomus tumors on the left scapular region. Histologic examination revealed a typical non‐capsulated glomangioma in the middle and deep dermis; by electron microscopic examination, the tumor cells were seen to exhibit a characteristic smooth muscle cell structure. Thermographic examination revealed the higher temperature of the tumor. Within a year, the tumor showed a partial involution. We think this is the first report of multiple glomus tumor showing a partial involution.
ICAM‐1 and LFA‐1 Expressions in the Lesional Skin of Annular Erythema Associated with Sjögren Syndrome
Authors: Katayama Ichiro , Asai Toshiya , Nishiyama Shigeo , Nishioka Kiyoshi 
Published: April 2015

AbstractICAM‐1 and LFA‐1 expression was studied in the lesional skin of ten cases of annular erythema associated with Sjögren syndrome. Most of the infiltrating mononuclear cells around blood vessels expressed LFA‐1 in addition to its strong expression on vascular endothelial cells and focal expression on the epidermal basal cell layer in 3 cases. ICAM‐1 expression on vascular endothelial cells was similar to LFA‐1, although relatively focal and weak expression was observed on mononuclear cells. ICAM‐1 expression on keratinocytes was focal and limited to the basal cell layer in annular erythema. These findings suggest that strong expression of ICAM‐1 on endothelial cells but not keratinocytes and LFA‐1 on mononuclear cells might play some role in the induction of skin lesions in annular erythema associated with Sjögren syndrome.
Nail Abrasion: A New Treatment for Ingrown Toe‐nails
Authors: Maeda Naonori , Mizuno Nobuyuki , Ichikawa Kazuhiko 
Published: April 2015

AbstractA simple new method for the treatment of ingrown toe‐nails was devised and applied to 33 toe‐nails in 22 patients. The entire nail surface, except for the margin, was abraded until the nail became flexible with a Schreu's skin grinder equipped with a steel bar. When there was infection or granulation of the nail wall, the imbedded nail corner was trimmed before abrasion. The patients underwent additional treatments when one treatment was not enough to achieve cure or when discomfort appeared, which was the first symptom of recurrence. The average number and duration of treatments was 2.9 times and 16 months, respectively. Relief from pain occurred in all patients soon after abrasion was performed. Recurrence of infection and granulation was observed in only one patient. Five patients (23%) remained problem‐free for more than one year without any additional treatment, because their incurved nail was gradually improved in shape by repetition of this procedure. This therapy was particularly effective in patients with severely incurved nails.
The Synergistic Effect of Isonicotinic Acid Hydrazide (INH) and Griseofulvin (GF) on Porphyrin Metabolism
Authors: Watanabe Masahisa 
Published: April 2015

AbstractAbnormal porphyrin metabolism can be induced by several chemicals. To investigate the synergistic effect on porphyrinopathy of isonicotinic acid hydrazide (INH) with a low concentration of griseofulvin (GF), the two chemicals were given to mice simultaneously. INH was added to drinking water at a concentration of 0.05%. GF was mixed with feed at a concentration of 0.1%. The mice (dd‐y strain) were divided into four groups. Those in group A were fed normally. Group B received only 0.1% GF, group C received only 0.05% INH, and group D received both 0.1% GF and 0.05% INH. The treatment was continued for 13 to 30 weeks. After treatment, the mice were anesthetized and sacrificed. The liver and whole blood were taken for analysis of porphyrins. The results revealed a slight elevation of erythrocytic porphyrins in the groups treated with 0.1% GF or 0.05% INH alone and remarkable abnormalities in the hepatic and erythrocytic porphyrin levels of the group simultaneously treated with both chemicals. These results show that INH itself may have a small potential for the induction of porphyric abnormalities, and that the administration of INH with a low concentration of GF induces marked porphyrinopathy in dd‐y strain mice.
Multiple Trichodiscomas: Histogenetical Observations
Authors: Requena Luis , Schöendorff Cristina , López M. , Yus Evaristo Sánchez 
Published: April 2015

AbstractA 23‐year‐old man with multiple trichodiscomas on his face is described. Four papules were histologically examinated, and all of them showed similar findings, a dermal fibrovascular proliferation with abundant ground substance between collagen bundles and an absence of elastic fibers. We found no evidence to establish a relationship between trichodiscomas and hair disk, and, in our opinion, these lesions should be included into the spectrum of hyperplasia of the adventicial dermis.
Effects of Subminimal Inhibitory Concentrations of Erythromycin, Tetracycline, Clindamycin, and Minocycline on the Neutrophil Chemotactic Factor Production in Propionibacterium acnes Biotypes 1–5
Authors: Akamatsu Hirohiko , Nishijima Setsuko , Takahashi Megumi , Ushijima Tsutomu , Asada Yasuo 
Published: April 2015

AbstractBiotypes 1–5 Propionibacterium acnes (P. acnes) strains were grown in the presence of 1/10 minimal inhibitory concentrations (sub‐MIC) of erythromycin (EM), tetracycline (TC), clindamycin (CLDM), or minocycline (MINO) and their culture filtrates were assayed for human neutrophil chemotactic activity using Boyden chamber methods.The addition of sub‐MIC of MINO to the medium strongly suppressed the neutrophil chemotactic activity of the culture filtrates of P. acnes strains of all biotypes. In contrast, with sub‐MIC of EM, TC, or CLDM, the activity of the culture filtrates of P. acnes strains of biotypes 2 and 3 were suppressed but those of biotypes 1, 2, and 5 were not.These results indicate that sub‐MIC of MINO is capable of decreasing the inflammatory capacity of P. acnes strains of all biotypes.
Effects of Cepharanthin on Neutrophil Chemotaxis, Phagocytosis, and Reactive Oxygen Species Generation
Authors: Akamatsu Hirohiko , Komura Jinro , Asada Yasuo , Niwa Yukie 
Published: April 2015

AbstractThe effects of cepharanthin on inflammatory parameters such as neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation, were examined. Cepharanthin significantly decreased the levels of O2−, H2O2, and OH. generated by neutrophils. H2O2 and OH. generated in a cell‐free, xanthine‐xanthine oxidase system were also reduced in the presence of cepharanthin. However, the drug did not affect neutrophil chemotaxis or phagocytosis. The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti‐inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation.
Unilateral Dysplastic Nevi Associated with Malignant Melanoma
Authors: Misago Noriyuki , Takahashi Masahiro , Kohda Hiromu 
Published: April 2015

AbstractA case of dysplastic nevi associated with malignant melanoma was reported. The case was characterized by unilateral distribution of dysplastic nevi. Multiple dysplastic nevi were observed only dorsally on the patient's left upper quadrant. To the best of our knowledge, the report of this form of dysplastic nevi is the first in Japan. In addition, dysplastic nevus cell nests were present in histologic contiguity with intraepidermal proliferation of melanoma in the radial growth phase. Histological evidence suggested that the melanoma in our case had probably been derived from the context of dysplastic nevus.
A Case of Idiopathic Vulvar Calcinosis: The First in Japan
Authors: Fukaya Yoshihide , Ueda Hiroshi 
Published: April 2015

AbstractIdiopathic calcinosis of the scrotum is a rare condition of unknown etiology. As counterparts of this male disorder, only two female cases have been reported (1, 2). We report a third case, the first of its kind, in Japan. Histochemical stains revealed acid mucopolysaccharide (acid‐MPS) within the calcinosis and many infiltrated mast cells near it; these might histogenese the calcium deposition. Immunohistochemically, polyclonal carcinoembryonic antigen (CEA) and keratin stains revealed no positive cells near the calcium depositions.
The Koebner Phenomenon in Eruptive Xanthoma
Authors: Miwa Norimasa , Kanzaki Tamotsu 
Published: April 2015

AbstractA 49‐year‐old woman with Type V hyperlipidemia had yellow papules smaller than 3 mm in diameter with red haloes on her elbows, shoulder, buttocks, and hands. Two linear lesions composed of papules arising at the sites of skin previously injured by a cat scratch were observed. Histopathological examination of these papules revealed the presence of many foam cells in the dermis which stained positively with oil red O stain. A survey of the literature found only 5 cases of the Koebner phenomenon in xanthoma.
A Case of Pyoderma Vegetans and the Follicular Occlusion Triad
Authors: Boyd Alan S. , Zemtsov Alexander 
Published: April 2015

AbstractA case of pyoderma vegetans (PYV) and hidradenitis suppurativa (HS) is described. Our patient had a previous history of perifolliculitis capitis abscedens et suffodiens and acne conglobata. Direct immunofluorescence findings ruled out pemphigus vegetans and suggested a potential pathogenic mechanism.
Muir‐Torre Syndrome
Authors: Narita Hajime , Kanzaki Tamotsu , Yokota Michiko , Matsuba Shozo 
Published: April 2015

AbstractMuir‐Torre syndrome is characterized by multiple sebaceous tumors, various internal malignancies and an autosomal dominant inheritance. We herein report a typical case. The patient was a 69‐year‐old man with sebaceous adenomas, a keratoacanthoma, and actinic keratosis in addition to carcinomas of the prostate, colon, duodenum, and larynx. His family members also suffered from multiple cancers.
Lipoatrophic Diabetes
Authors: Sasaki Tetsuo , Ono Hideki , Nakajima Hiroshi , Sugimoto Junichi 
Published: April 2015

AbstractA female patient with acanthosis nigricans, insulin resistant diabetes, and generalized lipoatrophy is reported. The patient developed skin pigmentation and acanthosis nigricans around the age of 34. Arthralgia, muscle weakness, and peripheral neuropathy were also present when she first visited us at 36 years of age. Dermatomyositis, systemic sclerosis, and internal malignancy were ruled out, and the diagnosis of acanthosis nigricans and insulin resistant diabetes was made. Her diabetes gradually worsened and, since the age of 39, she has been treated with an oral anti‐diabetic drug. Around the age of 47, generalized lipoatrophy became prominent Insulin receptor studies ruled out insulin resistant diabetes type A and B. At this point, we diagnosed this patient as having lipoatrophic diabetes, which is a syndrome characterized by insulin resistant diabetes, acanthosis nigricans, generalized lipoatrophy, and other metabolic disturbances. The control of her diabetes has been poor, and diabetic neuropathy and lipoatrophy‐induced painful skin lesions such as clavus and tylosis have been persistent The present case indicates the importance of careful skin examinations in the diagnosis of this syndrome.
Necrolytic Migratory Erythema in Glucagonoma Syndrome
Authors: Chong Lai‐Yin , Lai Cham‐Fai , Woo Chih‐Hsiang , Leung Yuet‐Foon , Greig Janes Donald , Khoo Ui‐Soon 
Published: April 2015

AbstractA 32‐year‐old female Chinese presenting with typical features of necrolytic migratory erythema due to glucagonoma syndrome is reported. The clinical, biochemical, histopathological, and electron‐microscopic findings are described. Various different aspects of this rare entity are discussed.
Hereditary Benign Telangiectasia: Two Case Reports
Authors: Puppin Douglas , Rybojad Michel , Morel Patrice 
Published: April 2015

AbstractWe present two cases of hereditary benign telangiectasia (HBT) in which the genetic findings are compatible with an autosomal dominant hypothesis.The lesions persisted indefinitely for many years without effect on the general health of the patients.The term hereditary benign telangiectasia distinguishes the disorder from the more serious hereditary hemorrhagic telangiectasia (Rendu‐Osler‐Weber). The etiology remains unknown. The condition causes only cosmetic disability and is not associated with any other diseases.
Serum Hormone Levels in Men with Severe Acne
Authors: Aizawa Hiroshi , Niimura Michihito 
Published: April 2015

AbstractIn order to evaluate the hormonal milieu in young men with severe acne, we measured serum estradiol (E2), total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), dehydro‐epiandrosterone sulfate (DHEA‐S), and sex hormone binding globulin (SHBG) levels in sixteen male patients aged 20–30 years with severe acne, including twelve cases of nodular‐cystic acne, and in seventeen age‐matched normal controls.There were no significant differences in the serum levels of T, FT, DHT, DHEA‐S, or SHBG between the patients and the controls, but serum E2 was significantly higher in the patient population.Thus, the hemodynamics of serum androgens in male patients with acne do not seem to differ significantly from that of normal controls. Elevated E2 levels might affect the inflammatory response of acne vulgaris through the release of thymic hormones, as reported in the literature.
Two Patients with Solar Urticaria Manifesting Pruritic Erythema
Authors: Torinuki Wakio 
Published: April 2015

AbstractTwo patients with solar urticaria are described. They complained of transient pruritic erythema, but not frank wheal, on sun‐exposed areas. However, urticarial wheals were elicited by polychromatic radiation in the ultraviolet and visible light ranges; the action spectra for solar urticaria ranged from 400 to 550 nm in case 1 and from UVA to 550 nm in case 2. In patients manifesting only transient pruritic erythema on sun‐exposed areas, phototests are essential for making a confident diagnosis of solar urticaria.
Keratohyalin, Trichohyalin and Keratohyalin‐Trichohyalin Hybrid Granules: An Overview
Authors: Manabe Motomu , O'Guin W. Michael 
Published: April 2015

AbstractFilaggrin and trichohyalin are the two major intermediate filament associated proteins which interact with keratin filaments in the skin. These two proteins initially accumulate in cytoplasmic granules called keratohyalin or trichohyalin granules which provide prominent morphological hallmarks of differentiation in the epidermis and the inner root sheath of hair follicles, respectively. The contents of each of these granules are modified and subsequently released into the cytoplasm of the fully mature cells where they function in the role of aggregating keratin filament bundles. We are beginning to identify several important aspects relative to the unique biological functions of both filaggrin and trichohyalin during the late stages of keratinocyte differentiation. This overview summarizes recent work on these proteins and will also highlight the existence of novel cytoplasmic granules, keratohyalin‐trichohyalin hybrid granules, in dorsal tongue epithelia.
The Neurofibromatosis Type 1 (NF1) Gene: Identification and Partial Characterization of a Putative Tumor Suppressor Gene
Authors: O'Connell Peter , Cawthon Richard , Xu Gang‐Feng , Li Ying , Viskochil David , White Ray 
Published: April 2015

AbstractThe NF1 gene has been isolated and partially characterized. The discovery that NF1 functions as a ras GTPase activator protein has led to new opportunities for understanding the pathology of this disease. The approximately 11 kilobase (kb) NF1 consensus cDNA sequence contains an open reading frame encoding a peptide of 2818 amino acids. DNA blot and polymerase chain reaction analysis indicate that the NF1 gene consists of over 50 exons spanning 300 kb of chromosome 17.
CT and MR Imaging of Intracranial Tuberous Sclerosis
Authors: Houser O. Wayne , Gomez Manuel R. 
Published: April 2015

AbstractCT and MR have permitted radiology to play a greater, but not definitive, role in detecting the pathologic components of tuberous sclerosis. SEN may be identified in only 80% of patients. Tubers are more ubiquitous and readily identified by MR in children and adults when the brain is myelinated. Since tubers are predominately peripheral hypomyelinated lesions, the detection of small lesions may be delayed until an infant is over 16–18 months of age when the myelin will have extended to the junction between the cortical white and gray matter. SEGA typically evolve later during the first and second decades of life. Successful genetic counseling implies a need to detect tuberous sclerosis at a stage during infancy when imaging may fail to confirm the diagnosis, so tuberous sclerosis remains a clinical diagnosis.
The Role of Metal Allergy and Local Hyperhidrosis in the Pathogenesis of Pompholyx
Authors: Yokozeki Hiroo , Katayama Ichiro , Nishioka Kiyoshi , Kinoshita Masako , Nishiyama Shigeo 
Published: April 2015

AbstractPompholyx (Dyshidrosis) is a disease of unknown etiology presenting as symmetrical, vesicular hand and foot dermatitis. To clarify the pathogenetic role of sweat and metal allergy, twenty five patients with pompholyx were examined with respect to their perspiration volume using equipment that continuously recorded the local perspiration volume. Patients were also examined for metal allergy by patch testing and oral challenge tests. The perspiration volumes were measured using recently developed equipment for continuous recording of local perspiration volume (Kenz‐Perspiro oss‐100®). The perspiration volume of pompholyx patients was found to be 2.5 times higher than that of age‐matched normal controls. Twenty percent of the patients showed sensitivity to chromate, 16% to cobalt, and 28% to nickel on patch testing. Six patients with positive results were challenged orally in a controlled trial with 2.5 mg nickel, 1 mg cobalt, or 2.5 mg chromium. Four of them (67%) showed vesicular reactions on their hands with challenge testing. These results indicated a sensitivity to metal compounds which, in combination with local hyperhidrosis, may contribute to the development of vesicular lesions in pompholyx.