bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal dietary deficiency in choline reduced levels of MMP-2 levels in blood and brain tissue of male offspring mice
Authors: Esfandiarei Mitra , Strash Shawn G.U. , Covaleski Amanda , Ille Sharadyn , Li Wei-dang , Jadavji Nafisa M. 
Published: July 2024

AbstractIschemic stroke is one of the leading causes of disability and death globally, with a rising incidence in younger age groups. It’s well known that maternal diet during pregnancy and lactation is vital for the early neurodevelopment of offspring. One-carbon (1C) metabolism, including folic acid and choline, plays a vital role in closure of the neural tubein utero. However, the impact of maternal dietary deficiencies in 1C on offspring neurological function following ischemic stroke later in life remains undefined. The aim of this study was to investigate inflammation in blood and brain tissue of offspring from mothers deficient in dietary folic acid or choline. Female mice were maintained on either a control or deficient diets prior to and during pregnancy and lactation. When offspring were 3-months of age, ischemic stroke was induced. One and half months later blood and brain tissue were collected. We measured levels of matrix-metalloproteases (MMP)-2 and 9 in both plasma and brain tissue, and report reduced levels of MMP-2 in both, with no changes observed in MMP-9. This observation supports our working hypothesis that maternal dietary deficiencies in folic acid or choline during early neurodevelopment impact the levels of inflammation in offspring after ischemic stroke.
Two for tau: Automated model discovery reveals two-stage tau aggregation dynamics in Alzheimer’s disease
Authors: Stockman Charles A. , Goriely Alain , Kuhl Ellen ,   and the Alzheimer’s Disease Neuroimaging Initiative
Published: July 2024

ABSTRACTAlzheimer’s disease is a neurodegenerative disorder characterized by the presence of amyloid-βplaques and the accumulation of misfolded tau proteins and neurofibrillary tangles in the brain. A thorough understanding of the local accumulation of tau is critical to develop effective therapeutic strategies. Tau pathology has traditionally been described using reaction-diffusion models, which succeed in capturing the global spread, but fail to accurately describe the local aggregation dynamics. Current mathematical models enforce a single-peak behavior in tau aggregation, which does not align well with clinical observations. Here we identify a more accurate description of tau aggregation that reflects the complex patterns observed in patients. We propose an innovative approach that uses constitutive neural networks to autonomously discover bell-shaped aggregation functions with multiple peaks from clinical positron emission tomography (PET) data of misfolded tau protein. Our method reveals previously overlooked two-stage aggregation dynamics by uncovering a twoterm ordinary differential equation that links the local accumulation rate to the tau concentration. When trained on data from amyloid-βpositive and negative subjects, the neural network clearly distinguishes between both groups and uncovers a more subtle relationship between amyloid-βand tau than previously postulated. In line with the amyloid-tau dual pathway hypothesis, our results show that the presence of toxic amyloid-βinfluences the accumulation of tau, particularly in the earlier disease stages. We expect that our approach to autonomously discover the accumulation dynamics of pathological proteins will improve simulations of tau dynamics in Alzheimer’s disease and provide new insights into disease progression.
Secondary metabolites and their impact on symbiotic interactions in the ambrosia fungusGeosmithia eupagioceri
Authors: Kolařík Miroslav , Stodůlková Eva , Kajzrová Soňa , Semerád Jaroslav , Hubert Jan , Kuzma Marek , Šulc Miroslav , Císařová Ivana , Jašica Andrej , Wennrich Jan-Peer , Hulcr Jiří , Flieger Miroslav 
Published: July 2024

ABSTRACTAmbrosia fungi colonize freshly dead trees, sequester nutrients, and serve as nutritional source for ambrosia beetles in exchange for dispersal. A key aspect of this symbiosis is the ability of fungi to colonize and dominate the wood around the beetle tunnels, forming a monospecific nutritional mycelium in the beetle gallery. Hypotheses for these dynamics include active beetle management, fungal inoculation priority, and the fungus’s chemical ecology facilitating resource capture and competition. The ecological role of allelochemicals produced by ambrosia fungi is unknown, although they may suppress microbes while being harmless to beetles, which has potential medical or food technology applications. This study presents a comprehensive analysis of secondary metabolites from the ambrosia fungusGeosmithia eupagioceri(Ascomycota: Hypocreales). Eight extracellular compounds were identifiedin vitro: 5-hydroxymethyl-2-furancarboxylic acid, 4-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, 4-hydroxyphenylacetic acid (4-HPA), 4-HPA methyl ester, tyrosol, and thymine. Most compounds show cross-taxon activity, suppressing the growth of bacteria, fungi, a nematode, and a mite. We have shown that often overlooked chemically simple compounds may have activities leading to increased fitness of beetle hosts, including previously unconsidered activity against mites and nematodes. For the first time, we point out that these compounds also have the previously unconsidered potential to modulate the physiology of their producer (by inducing symbiotic morphology by quorum sensing mechanisms), the beetle host and associated microbes through synergism. Furthermore, we have shown that the ambrosia fungi have biotechnological potential in the search for growth suppressors of microorganisms and invertebrates, not toxic to humans.IMPORTANCEBark and ambrosia beetles and their microbial symbionts play crucial roles in forest ecosystems by aiding in the decomposition of dead trees, nutrient cycling, and habitat creation. However, they can cause extensive damage to both natural and planted forests by killing trees. Our study has led to a fundamental shift in the understanding of interactions between beetle symbiotic fungi and the environment, mediated by secondary metabolites. Newly, we show that these substances can not only be antimicrobial but also suppress the growth of mites, nematodes, but also can modulate the physiology of the producer fungus and potentially the host beetle and associated microbes. Our study, although conducted on a relatively artificial system with the need for validation on other lineages of ambrosia fungi, suggests entirely new research directions in the understanding of bark beetle holobiont and ambrosia beetles.
The evolution of an individual-like dispersive stage in colonial siphonophores
Authors: Mańko Maciej K. , Munro Catriona , Leclère Lucas 
Published: July 2024

AbstractEvolutionary transitions between individual and colonial organisms remain enigmatic. Siphonophores, abundant pelagic cnidarians, exhibit a complex colony structure composed of repeated individual (zooid) clusters called cormidia. Many siphonophores release their posterior-most cormidia as independent fragments known as eudoxids, ensuring sexual reproduction. However, the mechanisms of eudoxid production and its evolutionary origins are unknown. Using live imaging, immunohistochemistry and pharmacological inhibition we provide a mechanistic understanding of eudoxid formation. We demonstrate that eudoxid release is controlled by a dedicated muscle and involves tissue remodeling, leading to the formation of an integrated dispersive unit with specific behaviors and a different buoyancy. We show that eudoxids and parental colonies often have different spatial or temporal distributions, suggesting niche partitioning. We infer that eudoxids evolved once through the concomitant evolution of multiple cormidium subparts. This study reveals how the acquisition of an individual-like dispersal stage, through muscle evolution and colony modification, contributed to the ecological success of a primary carnivore in marine planktonic ecosystems.TeaserCo-option of a muscle in siphonophores enabled life cycle complexification and ecological diversification
Directing entanglement spreading by means of a quantum East/West heterojunction structure
Authors: Chen Guanhua , Yao Yao 
Published: July 2024

We extend the translationally invariant quantum East model to an inhomogeneous chain with East/West heterojunction structure. In analogy to the quantum diffusion of particles, we observe a plateaus-shaped entanglement entropy spreading in the heterojunction during time evolution that can be regarded as continuous cycles in a quantum heat engine. In order to figure out the possibility of manipulating the entanglement entropy as a quantum resource, the entropy growth is shown to be determined by the initial occupation and the site-dependent chemical potential, and the former is equivalent to an effective temperature. Through fine adjustment of these parameters, we discover the entanglement flow is simply superposed with those from two sources of the chain. An intriguing relation between our model and the traditional heat engines is subsequently established.

Published by the American Physical Society
2024
Societal impact of Brand Public Relations on gender equality: evidence for a mediation-type mechanism
Authors: Chmiel Michal 
Published: July 2024

PurposeThe purpose of the project was to identify a mechanism of causal relationship between Brand Public Relations (BPR) and societal change in the perception of women gender roles.Design/methodology/approachExperimental evidence was obtained in three countries (N = 378) to examine the mechanism of societal impact of BPR. Effects of spillover of evaluations between two sub-brands of a house of brands company, caused by positive publicity about communication co-created by Public Relations (PR), were analysed.FindingsFindings supported the existence of a positive spillover of evaluations. A mechanism of the societal impact of PR was also captured: an indirect effect of news stories about a non-objectifying portrayal of women in the male reference brand on the typicality of a non-stereotypical women role in society was demonstrated.Research limitations/implicationsExperiments were conducted over a period of three years, during which publics perception of brands' communication about gender portrayal might have changed.Practical implicationsThe paper argues for greater recognition of brand public relations professionals as co-creators of promotional brand communication. It gives evidence that one of the unique competencies of BPR is insight into publics and predicting long-term consequences of brand communication.Social implicationsThe findings of the research project suggest a mediated nature of influence of BPR on the perception of typicality of gender (women) roles in society. PR communicators should learn what areas of practice of PR require specific skills for the function of PR to develop the new competence.Originality/valueThis paper is the first one that aimed at establishing a common terminological framework of the societal impact of public relations.
The role of governance in mitigating an epidemic disease: evidence from HIV prevalence in 45 Sub-Saharan African countries, 1996–2019
Authors: Lee Moonsoo , Nam Yunmin 
Published: July 2024

PurposeThis study proposed a theoretical framework to illustrate how governance can be instrumental in preventing the proliferation of HIV. It decomposed governance into six multidimensional facets and empirically examined their effects on HIV prevalence.Design/methodology/approachThe study utilized panel data from 45 sub-Saharan African countries from 1996 to 2019. HIV prevalence, the dependent variable, was estimated based on the number of adults aged 15–49 years infected with HIV, irrespective of the progression to AIDS symptoms. The independent variables included governance and its six dimensions: voice and accountability, political stability, government effectiveness, regulatory quality, rule of law, and control of corruption. The analysis incorporated the random and fixed effects models while controlling for economic development, economic inequality, foreign aid, sanitation, and population.FindingsThe findings revealed a significant association between good governance and lower HIV prevalence. Improved governance quality in sub-Saharan African countries has led to a reduction in HIV prevalence among adults. Specifically, governance dimensions, such as voice and accountability, political stability, rule of law, and control of corruption, contributed to reducing HIV prevalence. Conversely, government effectiveness and regulatory quality did not show significant impacts on HIV prevalence.Originality/valueThis study underscores the significant role of good governance in effectively curbing the spread of epidemic diseases, highlighting its importance in controlling HIV in sub-Saharan African countries.
Switching to green vehicles for last-mile delivery: why perceived green product knowledge, consumption values and environmental concern matter
Authors: Le Xuan Cu 
Published: July 2024

PurposeThis study investigated the intention of carriers to switch to green vehicles in last-mile delivery (GVLDs) in an emerging market.Design/methodology/approachA research model was developed based on the association between consumption value theory (CVT), perceived GVLD knowledge and environmental concern. An online survey was administered to carriers who use conventional vehicles for last-mile delivery. This study examined the model using structural equation modeling.FindingsResults indicate that environmental concern and attitudes toward adopting GVLDs are significantly cultivated through consumption value. Specifically, epistemic value was the most significant in promoting environmental awareness, while social value was paramount in fostering attitudes toward GVLDs. Furthermore, perceived GVLD knowledge motivated consumption value. Similarly, environmental concern positively impacted attitudes toward adopting GVLDs. Finally, environmental concerns and attitudes induced carriers’ intention to switch to GVLDs.Practical implicationsThe findings can help policymakers, manufacturers and logistics providers understand carriers’ decisions of shifting to GVLDs from a perspective of perceived consumption value, green product knowledge and environmental preservation while discussing practical recommendations for promoting the switch to GVLDs.Originality/valueThis study is an early endeavor that elucidates the switching behavior toward adopting GVLDs. It emphasizes incorporating perceived GVLD knowledge and environmental concern into CVT in the context of a developing country. This study enriches the understanding of how to promote environmental awareness and attitudes toward adopting GVLDs.
The spillover effect of Chinese sportswear brands' relationship quality: a perspective of Confucian yuanfen culture
Authors: Yang Ruichen , Song Hemin 
Published: July 2024

PurposeChinese consumers' brand preferences are shifting from foreign sportswear brands to domestic ones. This indicates an increasingly strong relationship between Chinese consumers and domestic sportswear brands. The purpose of this study is to explore the spillover effect of Chinese domestic sportswear brands’ relationship quality to uncover the psychological mechanisms driving this preference shift.Design/methodology/approachThe study used a brand relationship quality scale based on Chinese Confucian yuanfen culture, considering it as a second-order reflective-formative construct. The survey generated 326 valid responses online. Due to the presence of second-order reflective-formative construct in the variables, SmartPLS 4.0 was used for hypothesis testing.FindingsInteraction belief, intimate interaction and happiness as formative dimensions of Confucian yuanfen brand relationship quality are validated, while emotional expression and tolerance are not. The Confucian yuanfen brand relationship quality has a spillover effect on product origin image and domestic sportswear brand preference. Product origin image has a mediating role between Confucian yuanfen brand relationship quality and domestic sportswear brand preference. However, consumer xenocentrism does not moderate the spillover effect of Confucian yuanfen brand relationship quality on domestic sportswear brand preference.Originality/valueThis study tests brand relationship quality from Confucian yuanfen perspective as a second-order reflective-formative construct. It contributes to understanding how Chinese consumers perceive their relationships with domestic sportswear brands. The results advance the current body of knowledge on brand relationship quality and spillover effect in sports marketing, indicating that Chinese sportswear brands can explore the possibility of co-opetition to achieve mutual benefits.
An automatic robot for ultrasonic partial discharge detection of gas-insulated switchgear
Authors: Yang Run , Li Jingru , Zhu Taiyun , Yang Wei , Hu Di , Dong Erbao 
Published: July 2024

Purpose
Gas-insulated switchgear (GIS) stands as a pivotal component in power systems, susceptible to partial discharge occurrences. Nevertheless, manual inspection proves labor-intensive, exhibits a low defect detection rate. Conventional inspection robots face limitations, unable to perform live line measurements or adapt effectively to diverse environmental conditions. This paper aims to introduce a novel solution: the GIS ultrasonic partial discharge detection robot (GBOT), designed to assume the role of substation personnel in inspection tasks.

Design/methodology/approach
GBOT is a mobile manipulator system divided into three subsystems: autonomous location and navigation, vision-guided and force-controlled manipulator and data detection and analysis. These subsystems collaborate, incorporating simultaneous localization and mapping, path planning, target recognition and signal processing, admittance control. This paper also introduces a path planning method designed to adapt to the substation environment. In addition, a flexible end effector is designed for full contact between the probe and the device.

Findings
The robot fulfills the requirements for substation GIS inspections. It can conduct efficient and low-cost path planning with narrow passages in the constructed substation map, realizes a sufficiently stable detection contact and perform high defect detection rate.

Practical implications
The robot mitigates the labor intensity of grid maintenance personnel, enhances inspection efficiency and safety and advances the intelligence and digitization of power equipment maintenance and monitoring. This research also provides valuable insights for the broader application of mobile manipulators in diverse fields.

Originality/value
The robot is a mobile manipulator system used in GIS detection, offering a viable alternative to grid personnel for equipment inspections. Comparing with the previous robotic systems, this system can work in live electrical detection, demonstrating robust environmental adaptability and superior efficiency.
Adaptive variable impedance force/position hybrid control for large surface polishing
Authors: Zhu Zhixu , Zhang Hualiang , Liu Guanghui , Zhang Dongyang 
Published: July 2024

Purpose
This paper aims to propose a hybrid force/position controller based on the adaptive variable impedance.

Design/methodology/approach
First, the working space is divided into a force control subspace and a position subspace, the force control subspace adopts the position impedance control strategy. At the same time, the contact force model between the robot and the surface is analyzed in this space. Second, based on the traditional position impedance, the model reference adaptive control is introduced to provide an accurate reference position for the impedance controller. Then, the BP neural network is used to adjust the impedance parameters online.

Findings
The experimental results show that compared with the traditional PI control method, the proposed method has a higher flexibility, the dynamic response accommodation time is reduced by 7.688 s and the steady-state error is reduced by 30.531%. The overshoot of the contact force between the end of robot and the workpiece is reduced by 34.325% comparing with the fixed impedance control method.

Practical implications
The proposed control method compares with a hybrid force/position based on PI control method and a position fixed impedance control method by simulation and experiment.

Originality/value
The adaptive variable impedance control method improves accuracy of force tracking and solves the problem of the large surfaces with robot grinding often over-polished at the protrusion and under-polished at the concave.
Examining ChatGPT adoption among educators in higher educational institutions using extended UTAUT model
Authors: Bhat Mohd. Abass , Tiwari Chandan Kumar , Bhaskar Preeti , Khan Shagufta Tariq 
Published: July 2024

Purpose
Based on the Unified Theory of Acceptance and Use of Technology (UTAUT) model, this study aims to explore the factors influencing educators’ acceptance and utilization of chat generative pretrained transformer (ChatGPT) in the context of higher educational institutions. This study additionally examines the moderating influence of trust on the association between intention and adoption of ChatGPT.

Design/methodology/approach
A structured questionnaire was disseminated to 1,214 educators following the purposive sampling method. The hypothesized relationships between the extended UTAUT model constructs and ChatGPT adoption were examined using structural equation modeling.

Findings
The results of this study indicate positive impact of ChatGPT adoption and its use behavior (UB) among educators. Performance expectancy, effort expectancy, hedonic motivation, facilitating conditions and habit have a positive impact on behavior intention to use this tool among educators in higher education institutions, However, the educators intend to use ChatGPT in a personal capacity and are negatively influenced by the social groups. Moreover, behavior intention to adopt ChatGPT has a larger effect on the UB due to the higher involvement of trust.

Practical implications
This research adds to the literature on technology adoption by emphasizing the significance of trust in the adoption of emerging technologies, such as big language models. This study’s findings have implications for ChatGPT technology developers, legislators and academics considering the implementation of ChatGPT for teaching and research.

Originality/value
This research investigates ChatGPT adoption among higher education educators using the UTAUT model. It emphasizes the role of trust in adoption, highlights key adoption factors and reveals a paradox: educators are personally inclined to use ChatGPT but hesitant due to negative social influence. This study's novelty lies in its focus on trust and its implications for developers, legislators and educators, offering valuable insights for integrating ChatGPT in education.