bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium
Authors: Villaruz Liza C. , Socinski Mark A. , Abberbock Shira , Berry Lynne D. , Johnson Bruce E. , Kwiatkowski David J. , Iafrate A. John , Varella‐Garcia Marileila , Franklin Wilbur A. , Camidge D. Ross , Sequist Lecia V. , Haura Eric B. , Ladanyi Mark , Kurland Brenda F. , Kugler Kelly , Minna John D. , Bunn Paul A. , Kris Mark G. 
Published: October 2014

BACKGROUNDThe advent of effective targeted therapy for BRAFV600E‐mutant lung adenocarcinomas necessitates further exploration of the unique clinical features and behavior of advanced‐stage BRAF‐mutant lung adenocarcinomas.METHODSData were reviewed for patients with advanced lung adenocarcinomas enrolled in the Lung Cancer Mutation Consortium whose tumors underwent testing for mutations in epidermal growth factor receptor (EGFR), Kirsten rat sarcoma viral oncogene homolog (KRAS), human epidermal growth factor receptor 2 (HER2), AKT1, BRAF, dual‐specificity mitogen‐activated protein kinase kinase 1 (MEK1), neuroblastoma RAS viral (v‐ras) oncogene homolog (NRAS), and phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit α (PIK3CA); for anaplastic lymphoma kinase (ALK) translocations; and for MET amplification.RESULTSTwenty‐one BRAF mutations were identified in 951 patients with adenocarcinomas (2.2%; 95% confidence interval [CI], 1.4%‐3.4%): 17 (81%; 95% CI, 60%‐92%) were BRAFV600E mutations, and 4 were non‐BRAFV600E mutations. Among the 733 cases tested for all 10 genes, BRAF mutations were more likely to occur than most other genotypic abnormalities in current or former smokers (BRAF vs sensitizing EGFR, 82% vs 36%, mid‐P < .001; BRAF vs ALK, 39%, mid‐P = .003; BRAF vs other mutations, 49%, mid‐P = .02; BRAF vs patients with more than 1 oncogenic driver [doubleton], 46%, mid‐P = .04.) The double‐mutation rate was 16% among patients with BRAF mutations but 5% among patients with other genomic abnormalities (mid‐P = .045). Differences were not found in survival between patients with BRAF mutations and those with other genomic abnormalities (P > .20).CONCLUSIONSBRAF mutations occurred in 2.2% of advanced‐stage lung adenocarcinomas, were most commonly V600E, and were associated with distinct clinicopathologic features in comparison with other genomic subtypes and with a high mutation rate in more than 1 gene. These findings underscore the importance of comprehensive genomic profiling in assessing patients with advanced lung adenocarcinomas. Cancer 2015;121:448–456. © 2014 American Cancer Society.
A scalable approach to solving dense linear algebra problems on hybrid CPU‐GPU systems
Authors: Song Fengguang , Dongarra Jack 
Published: October 2014

SummaryAiming to fully exploit the computing power of all CPUs and all graphics processing units (GPUs) on hybrid CPU‐GPU systems to solve dense linear algebra problems, we design a class of heterogeneous tile algorithms to maximize the degree of parallelism, to minimize the communication volume, and to accommodate the heterogeneity between CPUs and GPUs. The new heterogeneous tile algorithms are executed upon our decentralized dynamic scheduling runtime system, which schedules a task graph dynamically and transfers data between compute nodes automatically. The runtime system uses a new distributed task assignment protocol to solve data dependencies between tasks without any coordination between processing units. By overlapping computation and communication through dynamic scheduling, we are able to attain scalable performance for the double‐precision Cholesky factorization and QR factorization. Our approach demonstrates a performance comparable to Intel MKL on shared‐memory multicore systems and better performance than both vendor (e.g., Intel MKL) and open source libraries (e.g., StarPU) in the following three environments: heterogeneous clusters with GPUs, conventional clusters without GPUs, and shared‐memory systems with multiple GPUs. Copyright © 2014 John Wiley & Sons, Ltd.
Rationalization of Dye Uptake on Titania Slides for Dye‐Sensitized Solar Cells by a Combined Chemometric and Structural Approach
Authors: Gianotti Valentina , Favaro Giada , Bonandini Luca , Palin Luca , Croce Gianluca , Boccaleri Enrico , Artuso Emma , van Beek Wouter , Barolo Claudia , Milanesio Marco 
Published: October 2014

AbstractA model photosensitizer (D5) for application in dye‐sensitized solar cells has been studied by a combination of XRD, theoretical calculations, and spectroscopic/chemometric methods. The conformational stability and flexibility of D5 and molecular interactions between adjacent molecules were characterized to obtain the driving forces that govern D5 uptake and grafting and to infer the most likely arrangement of the molecules on the surface of TiO2. A spectroscopic/chemometric approach was then used to yield information about the correlations between three variables that govern the uptake itself: D5 concentration, dispersant (chenodeoxycholic acid; CDCA) concentration, and contact time. The obtained regression model shows that large uptakes can be obtained at high D5 concentrations in the presence of CDCA with a long contact time, or in absence of CDCA if the contact time is short, which suggests how dye uptake and photovoltaic device preparation can be optimized.
Transient partial permeabilization with saponin enables cellular barcoding prior to surface marker staining
Authors: Behbehani Gregory K. , Thom Colin , Zunder Eli R. , Finck Rachel , Gaudilliere Brice , Fragiadakis Gabriela K. , Fantl Wendy J. , Nolan Garry P. 
Published: October 2014

AbstractFluorescent cellular barcoding and mass‐tag cellular barcoding are cytometric methods that enable high sample throughput, minimize inter‐sample variation, and reduce reagent consumption. Previously employed barcoding protocols require that barcoding be performed after surface marker staining, complicating combining the technique with measurement of alcohol‐sensitive surface epitopes. This report describes a method of barcoding fixed cells after a transient partial permeabilization with 0.02% saponin that results in efficient and consistent barcode staining with fluorescent or mass‐tagged reagents while preserving surface marker staining. This approach simplifies barcoding protocols and allows direct comparison of surface marker staining of multiple samples without concern for variations in the antibody cocktail volume, antigen‐antibody ratio, or machine sensitivity. Using this protocol, cellular barcoding can be used to reliably detect subtle differences in surface marker expression. © 2014 International Society for Advancement of Cytometry
Impacts of land use changes on hydrological components and macroinvertebrate distributions in the Poyang lake area
Authors: Schmalz B. , Kuemmerlen M. , Kiesel J. , Cai Q. , Jähnig S. C. , Fohrer N. 
Published: October 2014

AbstractLand use and land cover changes are important issues globally resulting in changing hydrological and ecological conditions. In addition to field sampling and measurements, we applied a model cascade comprising an ecohydrological model and a species distribution model. We developed five land use scenarios (three deforestation and two afforestation scenarios) for our Chinese study basin in the Poyang lake area. In detail, we assessed the impact of land use changes on the hydrologic regime and stream macroinvertebrate distributions for the most likely deforestation scenario.Simulated deforestation scenarios result in higher streamflow and surface runoff compared with the base model. The spatial distribution of stream macroinvertebrates, a group of organisms well known as water quality indicators, was modelled to describe the effect of the changing environmental conditions on the freshwater ecosystem. For the deforestation scenario, species richness was reduced, and the occurrence of the stonefly Togoperla sp. decreased considerably. Copyright © 2014 John Wiley & Sons, Ltd.
Interplay of Photoabsorption, Electronic Structure, and Recombination Rate of Charge Carriers on Visible Light Driven Photocatalytic Activity of Cu‐ and N‐Doped Ba3V2O8
Authors: Veldurthi Naveen Kumar , Bandipalli Priyanka , Ravi Gundeboina , Reddy Jitta Raju , Palla Suresh , Bhanuprakash Kotamarthi , Vithal Muga 
Published: October 2014

AbstractPalmierite Ba3V2O8 and related Cu‐ and N‐doped congeners were prepared by sol‐gel, ion‐exchange, and solid‐state reactions, respectively, with the aim of tailoring their optical, electronic, and photocatalytic properties. The catalysts were characterized by XRD analyis, UV/Vis diffuse reflectance spectroscopy, SEM with energy‐dispersive X‐ray spectroscopy, photoluminence spectroscopy, BET measurements, thermogravimetric analysis, X‐ray photoelectron spectroscopy, and TEM analysis. The electronic structures of Cu‐ and N‐doped optimal compositions were calculated theoretically on the basis of density functional theory. A series of photocatalytic degradation experiments of methylene blue under visible light irradiation disclosed the optimal dopant concentrations of Cu and N into Ba3V2O8, and the photocatalytic ability of the optimal compositions was also tested by the degradation of aniline. The differences in the degradation performance of Cu‐ and N‐doped samples are discussed on the basis of inextricably linked parameters such as photoabsorption, electronic structure, and mobility of the photoinduced charge carriers.
Porous Copper‐Modified Graphite Pencil Electrode for the Amperometric Detection of 4‐Nitrophenol
Authors: Kawde Abdel‐Nasser , Aziz Md. Abdul 
Published: October 2014

AbstractTo overcome the well‐known carbon electrodes surface fouling of phenols, we report on a simple and rapid method for the preparation of a disposable porous Cu‐modified graphite pencil electrode (Cu‐GPE) for sensing 4‐nitrophenol (4‐NP). The bare‐ and Cu‐modified graphite pencil electrodes were characterized by cyclic voltammetry and SEM. The two electrodes displayed distinct electrocatalytic activities in response to the electrochemical redox reaction of 4‐NP. A difference of three orders of magnitude is obtained on the amperometric detection limits of 1.9 µM on porous Cu‐modified vs. 1.0 mM on bare‐graphite pencil electrode at 3σ. The Cu‐GPEs are fabricated utilizing a simple single method, and at an extremely low cost with high stability, selectivity and sensitivity, offering a promising tool for sensing 4‐NP.
Pacemaker Activated by an Abiotic Biofuel Cell Operated in Human Serum Solution
Authors: Holade Yaovi , MacVittie Kevin , Conlon Tyler , Guz Nataliia , Servat Karine , Napporn Teko W. , Kokoh K. Boniface , Katz Evgeny 
Published: October 2014

AbstractAn “abiotic” biofuel cell composed of catalytic electrodes modified with inorganic nanostructured species was used to activate a pacemaker. The catalytic nanoparticles of various compositions, AuxPty, deposited on carbon black (CB) were prepared and extensively characterized to select the species with selectivity for glucose oxidation and oxygen reduction. Then two kinds of 3D‐electrode materials with different morphology, buckypaper composed of carbon nanotubes (ca. 50 nm diameter) and carbon paper made of carbon fibers (ca. 7 µm diameter), were used in a combination with different catalytic species. Finally, Au/CB nanospecies deposited on buckypaper were selected for catalyzing glucose oxidation (composing the biofuel cell anode) and Au60Pt40/CB species deposited on carbon paper were selected for catalyzing oxygen reduction (composing the biofuel cell cathode). The catalytic electrodes were characterized by cyclic voltammetry in an aqueous buffer solution and the polarization function for the biofuel cell was studied in a human serum solution. The open circuit voltage, Voc, short circuit current density, jsc, and maximum power produced by the biofuel cell, Pmax, were found as 0.35 V, 0.65 mA cm−2 and 104 µW, respectively (in human serum at 5.4 mM glucose). The biofuel cell produced the steady state open circuit voltage over 10 hours with its slow decrease over 50 hours originating from the glucose depletion and slow mass‐transport within the 3D‐electrode. The voltage produced by the biofuel cell was amplified with an energy harvesting circuit and applied to a pacemaker resulting in its proper operation. The present study continues the research line where different implantable (enzyme‐based or abiotic) biofuel cells are used for the activation of biomedical electronic devices, e.g., pacemakers.
Waste law framework for the recovery of material excavated from tunnels / Abfallrechtliche Rahmenbedingungen für die Verwertung von Tunnelausbruchmaterial
Authors: Danzer Mathilde 
Published: October 2014

AbstractThis paper has been conceived for the future “Leaflet for the reuse of the material excavated in tunnelling”. The goal was to explain the term “waste” in contrast to non‐waste (product), the requirements for dealing with wastes, the permissible recovery of wastes and the time when the end‐of‐waste starts. Apart from the passages of legal texts which are most important from the technical point of view, explanations, legal material and letters already written by the Federal Ministry of Agriculture, Forestry, Environment and Water Management on this issue have been used. Moreover the decisive provisions of the Landfill Ordinance 2008 and of the Law on the Remediation of Contaminated Sites are presented.Diese Arbeit wurde für das kommende “Merkblatt für die Verwertung von Tunnelausbruchmaterial” konzipiert und soll die Grundzüge der aktuellen abfallrechtlichen Situation in Österreich darstellen. Ziel war es, den Begriff Abfall gegenüber Nicht‐Abfall (Produkt), die Anforderungen an den Umgang mit Abfällen, die zulässige Verwertung von Abfällen und den Zeitpunkt, wann das Abfallende eintritt, zu erläutern. Neben den aus fachlicher Sicht wichtigsten Gesetzesstellen wurden Erläuterungen, Gesetzesmaterialien und bereits ergangene Schreiben des Bundesministeriums für Land‐ und Forstwirtschaft, Umwelt und Wasserwirtschaft verwendet. Darüber hinaus werden die maßgeblichen Bestimmungen der Deponieverordnung 2008 und des Altlastensanierungsgesetzes dargelegt.
Maintenance‐optimised drainage system for the New Semmering Base tunnel and Pummersdorf Tunnel / Instandhaltungsoptimiertes Entwässerungssystem für den Semmering‐Basistunnel neu und Tunnel Pummersdorf
Authors: Wagner Oliver K. , Koch Daniel , Lemmerer Johann , Druckfeuchter Hubert , Petraschek Thomas 
Published: October 2014

AbstractIn order to reduce operational interruptions for the maintenance of the drainage system, the ÖBB‐Infrastruktur AG has developed an innovative drainage flushing system, which has different features depending on tunnel system and overburden.Um Betriebseinschränkungen für die Dränageinstandhaltung zu reduzieren, wurden seitens der ÖBB‐Infrastruktur AG innovative Dränagespülsysteme entwickelt. Abhängig von Tunnelsystem und Überlagerung sind diese unterschiedlich ausgebildet.
Advance probing measures on the TBM drives of the south contracts of the Gotthard Base Tunnel – experience and implications for other projects / Vorauserkundungsmaßnahmen bei den TBM‐Vortrieben der Südlose des Gotthard‐Basistunnels – Erfahrungen und Folgerungen für andere Projekte
Authors: Rehbock‐Sander Michael , Wieland Gerd , Jesel Thomas 
Published: October 2014

AbstractThe investigation measures carried out for the construction of the Gotthard Base Tunnel provide a demonstrative example for dealing with geological risk through appropriate investigation at each state of the project. Due to the length and deep overburden, it was impossible to completely investigate the entire length of the tunnel in advance. The concept in the southern sections intended the performance of probing ahead of the machine only in particularly critical locations, with the tunnelling and lining concept for the individual sections being designed to cope with possible hazard scenarios for the section and the provision of more intensive probing ahead of the continued drive in order to specify the necessary constructional measures. In addition, massive formation water ingress was to be expected in certain sections, which could reach a high quantity and high pressures (up to 200 bars).The advance probing concept included in the contract for the almost 30 km long southern TBM drives of the Gotthard Base Tunnel with hammer drilling, seismic investigation and core drilling is described and the experience gained during the progress of the tunnel and the necessary adaptations are summarised. Suggestions are then derived for future projects.Die durchgeführten Erkundungsmaßnahmen beim Bau des Gotthard‐Basistunnels stellen ein anschauliches Beispiel für den Umgang mit dem Baugrundrisiko mittels phasengerechter Baugrunderkundung dar. Aufgrund der Länge und der großen Überlagerung war eine vorgängige vollumfängliche Erkundung über die gesamte Tunnellänge nicht möglich. Das Konzept in den südlichen Abschnitten sah vor, nur für die besonders kritischen Bereiche vorgängige Erkundungsmaßnahmen durchzuführen, die Vortriebs‐ und Ausbaukonzepte in den einzelnen Abschnitten auf die möglichen Gefährdungsbilder dieser Abschnitte auszulegen und die Vorauserkundungsmaßnahmen aus den laufenden Vortrieben zu intensivieren, um die erforderlichen baulichen Maßnahmen im Vortrieb festzulegen. Zudem musste in bestimmten Abschnitten mit massiven Bergwasserzutritten gerechnet werden, die einen hohe Schüttmenge und hohe Wasserdrücke (bis zu 200 bar) erreichen können.Das in den knapp 30 km langen südlichen TBM‐Vortrieben des Gotthard‐Basistunnels gemäß Werkvertrag vorgesehene Vorauserkundungskonzept mit Schlagbohrungen, Seismik und Kernbohrungen wird aufgezeigt, und die Erfahrungen und erforderlichen Anpassungen während der Vortriebsarbeiten werden dargestellt. Schlussendlich werden die Erkenntnisse aus den Vortriebsarbeiten zusammenfassend dargestellt und daraus Vorschläge für andere Projekte aufgezeigt.
Sustainability in infrastructure construction – on the transferability of assessment concepts for buildings to civil engineering works / Nachhaltigkeit im Infrastrukturbau – Zur Übertragbarkeit von Bewertungskonzepten für Gebäude auf den Tiefbau
Authors: Maydl Peter 
Published: October 2014

AbstractThe trend to sustainable construction in the building sector has greatly increased in recent years. In certain segments of the market (e.g. office and retail properties), building certificates are essential marketing aids and are having an increasing effect on competition, with questions of energy efficiency and interior air quality being of particular significance. A comprehensive series of European standards is now available, which also include a harmonised assessment concept. In infrastructure construction, this development has mostly been reflected in the estimation of lifecycle costs, durability and maintenance costs in bridge building and the recycling of material excavated from tunnels.The new EU construction products regulation has required since 01/07/2013 the recyclability and durability of structures (i.e. buildings and infrastructure works) as well as the use of environmentally compatible raw materials and secondary materials. This paper investigates the question, whether and to what extent the assessment concepts and methods that have been developed can be applied to the design of civil engineering works, as is currently under discussion by the technical committee CEN/TC 350 “Sustainability of construction works”.Der Trend zum nachhaltigen Bauen hat in den letzten Jahren im Hochbau stark zugenommen. In bestimmten Marktsegmenten (z. B. Büro‐ und Handelsimmobilien) sind Gebäudezertifikate unentbehrliche Vermarktungshilfen, die zunehmend den Wettbewerb beeinflussen, wobei oft Fragen der Energieeffizienz oder der Raumluftqualität im Vordergrund stehen. Mittlerweile steht ein umfassendes europäisches Regelwerk zur Verfügung, das auch ein harmonisiertes Bewertungskonzept umfasst. Im Infrastrukturbau konzentriert sich diese Entwicklung vor allem auf die Abschätzung von Lebenszykluskosten, Dauerhaftigkeit und Instandhaltungsaufwand im Brückenbau oder auf die Verwertung von Tunnelausbruch.Die neue EU‐Bauprodukteverordnung fordert seit 01.07.2013 die Rezyklierbarkeit und Dauerhaftigkeit von Bauwerken (also Gebäude und Infrastrukturbauten) sowie die Verwendung von umweltverträglichen Rohstoffen und Sekundärbaustoffen. Der vorliegende Beitrag geht der Frage nach, ob und in welchem Ausmaß die zwischenzeitlich entwickelten Bewertungskonzepte und Ansatzpunkte für die Planung auf den Tiefbau übertragen werden können, wie dies gegenwärtig auch im CEN/TC 350 “Sustainability of construction works” diskutiert wird.
The determination of performance‐ and payment‐relevant parameters in TBM tunnelling – State of the technology and outlook / Ermittlung leistungs‐ und vergütungsrelevanter Parameter für TVM‐Vortriebe – Stand der Technik und Ausblick
Authors: Galler Robert , Handke Dieter , Nolden Mario 
Published: October 2014

AbstractThe success of mechanised tunnelling is greatly influenced by the interactive behaviour of machine and ground. A multitude of published research and practice reports documents the problem of a targeted forecast based on tests and forecasting models [19]. The paper describes the currently used methods of estimating performance‐relevant parameters, including current research into the subject of crack propagation in solid rock and developments in disc force measurement on the tunnel boring machine and its forecasting from laboratory tests.Der Erfolg eines maschinellen Tunnelvortriebs wird maßgeblich vom Interaktionsverhalten Maschine‐Baugrund bestimmt. Die Vielzahl der veröffentlichten Forschungs‐ und Praxiserfahrungen dokumentiert die Problematik einer zielgerichteten Prognose auf der Basis von Versuchen und Prognosemodellen [19]. Im Beitrag werden die derzeit zur Anwendung kommenden Methoden zur Abschätzung leistungsrelevanter Parameter unter Einbeziehung der aktuell laufenden Forschungen zum Thema Rissausbreitung im Festgestein sowie der Entwicklungen zur Diskenkraftmessung an der Tunnelvortriebsmaschine und deren Prognose anhand von Laborversuchen dargelegt.