bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic posterior mesh rectopexy for rectal prolapse is a safe procedure in older patients: A prospective follow-up study
Authors: Dyrberg D.L. , Nordentoft T. , Rosenstock S. 
Published: January 2015

Background and aims: The aim of this study is to examine the clinical and functional outcome of laparoscopic posterior rectopexy in a consecutive series of adult patients with full-thickness rectal prolapse. Material and methods: Preoperative data on demography, life-style practices, medication, comorbidity, and previous surgery for rectal prolapse were ascertained from patient charts. Information on operative procedure, and pre- and postoperative complications were recorded. Short- and long-term follow-up were done after a median of 60 days and 2 years after surgery. Results: Between 1 February 2009 to 1 June 2012, 81 laparoscopic posterior rectopexies were done. Male-to-female ratio was 4:77, median age 73 [57–80.5] years and median ASA Grade 2. Conversion to open surgery was done in 6.2%, the median operating time was 82 min [66 - 102] and median length of hospital stay was 2 days [2–5.7]. Minor and major complications were seen in 5.3% and 14.8%, respectively. The 30-day mortality rate was 1.2%. Constipation or incontinence improved or disappeared in 65.2% and 74.4%, respectively. The cumulated recurrence rate was 11.1% after a median observation time of 2 years. Conclusion: Laparoscopic posterior rectopexy is a safe and well-tolerated procedure in older patients and can be done with acceptable complications and recurrence rates and short hospital stays. Laparoscopic posterior rectopexy seems to improve bowel function in many patients.
The impact of four family support programmes for people with a disability in Ireland
Authors: Daly Louise , Sharek Danika , DeVries Jan , Griffiths Colin , Sheerin Fintan , McBennett Padraig , Higgins Agnes 
Published: January 2015

Background: This article reports on an evaluation of four family support programmes in Ireland for families of people with a physical or an intellectual disability or autism. The focus of the evaluation, which took place within a year of the programmes’ completion, was on establishing whether the programmes had an impact on families’ capacity to effectively support their family member. Method: A mixed-method design was used, which included a survey ( n = 38) and interviews ( n = 19) with participating family members. Ethical approval for the study was given by the relevant university ethics committee. Results: Findings suggest that participation in the programmes enhanced knowledge, attitudes, and competencies of families and also impacted their ability to advocate for their family member and to connect with the community. Discussion and conclusions: Whilst outcomes were overwhelmingly positive, further follow-up would be required to ascertain if sustained capacity building took place.
Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells
Authors: Yu Xiaojun , Ilecka Marta , Bartlett Emmalene J. , Schneidt Viktor , Bhat Rauf , Mautner Josef , Feederle Regina , Delecluse Henri-Jacques 
Published: January 2015

Key PointsEpitopes in antigen-armed antibodies that target B-cell receptors are efficiently presented by B lymphoma cells to cytotoxic CD4+ T cells. Memory T cells activated by AgAbs ex vivo are able to kill targeted B lymphoma cells.
Circulating tumor cells in newly diagnosed inflammatory breast cancer
Authors: Mego Michal , Giordano Antonio , De Giorgi Ugo , Masuda Hiroko , Hsu Limin , Giuliano Mario , Fouad Tamer M , Dawood Shaheenah , Ueno Naoto T , Valero Vicente , Andreopoulou Eleni , Alvarez Ricardo H , Woodward Wendy A , Hortobagyi Gabriel N , Cristofanilli Massimo , Reuben James M 
Published: January 2015

Abstract
Introduction
Circulating tumor cells (CTCs) are an independent prognostic factor for progression-free survival (PFS) and overall survival (OS) in patients with metastatic breast cancer. Inflammatory breast cancer (IBC) is one of the most aggressive forms of breast cancer. The prognostic value of a CTC count in newly diagnosed IBC has not been established. The aim of this study was to assess the prognostic value of a baseline CTC count in patients with newly diagnosed IBC.

Methods
This retrospective study included 147 patients with newly diagnosed IBC (77 with locally advanced and 70 with metastatic IBC) treated with neoadjuvant therapy or first-line chemotherapy during the period from January 2004 through December 2012 at The University of Texas MD Anderson Cancer Center. CTCs were detected and enumerated by using the CellSearch system before patients were started with chemotherapy.

Results
The proportion of patients with ≥1 CTC was lower among patients with stage III than among patients with metastatic IBC (54.5% versus 84.3%; P = 0.0002); the proportion of patients with ≥5 CTCs was also lower for stage III than for metastatic IBC (19.5% versus 47.1%; P = 0.0004). Patients with fewer than five CTCs had significantly better progression-free survival (PFS) (hazard ratio (HR) = 0.60; P = 0.02) and overall survival (HR = 0.59; P = 0.03) than patients with five or more CTCs. Among patients with stage III IBC, there was a nonsignificant difference in PFS (HR = 0.66; 95% confidence interval (CI), 0.31 to 1.39; P = 0.29) and OS (HR = 0.54; 95% CI, 0.24 to 1.26; P = 0.48) in patients with no CTCs compared with patients with one or more CTCs. In multivariate analysis, CTC was prognostic for PFS and OS independent of clinical stage.

Conclusions
CTCs can be detected in a large proportion of patients with newly diagnosed IBC and are a strong predictor of worse prognosis in patients with newly diagnosed IBC.
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation
Authors: Burleigh Angela , McKinney Steven , Brimhall Jazmine , Yap Damian , Eirew Peter , Poon Steven , Ng Viola , Wan Adrian , Prentice Leah , Annab Lois , Barrett J Carl , Caldas Carlos , Eaves Connie , Aparicio Samuel 
Published: January 2015

Abstract
Introduction
The extracellular signals regulating mammary epithelial cell growth are of relevance to understanding the pathophysiology of mammary epithelia, yet they remain poorly characterized. In this study, we applied an unbiased approach to understanding the functional role of signalling molecules in several models of normal physiological growth and translated these results to the biological understanding of breast cancer subtypes.

Methods
We developed and utilized a cytogenetically normal clonal line of hTERT immortalized human mammary epithelial cells in a fibroblast-enhanced co-culture assay to conduct a genome-wide small interfering RNA (siRNA) screen for evaluation of the functional effect of silencing each gene. Our selected endpoint was inhibition of growth. In rigorous postscreen validation processes, including quantitative RT-PCR, to ensure on-target silencing, deconvolution of pooled siRNAs and independent confirmation of effects with lentiviral short-hairpin RNA constructs, we identified a subset of genes required for mammary epithelial cell growth. Using three-dimensional Matrigel growth and differentiation assays and primary human mammary epithelial cell colony assays, we confirmed that these growth effects were not limited to the 184-hTERT cell line. We utilized the METABRIC dataset of 1,998 breast cancer patients to evaluate both the differential expression of these genes across breast cancer subtypes and their prognostic significance.

Results
We identified 47 genes that are critically important for fibroblast-enhanced mammary epithelial cell growth. This group was enriched for several axonal guidance molecules and G protein–coupled receptors, as well as for the endothelin receptor PROCR. The majority of genes (43 of 47) identified in two dimensions were also required for three-dimensional growth, with HSD17B2, SNN and PROCR showing greater than tenfold reductions in acinar formation. Several genes, including PROCR and the neuronal pathfinding molecules EFNA4 and NTN1, were also required for proper differentiation and polarization in three-dimensional cultures. The 47 genes identified showed a significant nonrandom enrichment for differential expression among 10 molecular subtypes of breast cancer sampled from 1,998 patients. CD79A, SERPINH1, KCNJ5 and TMEM14C exhibited breast cancer subtype–independent overall survival differences.

Conclusion
Diverse transmembrane signals are required for mammary epithelial cell growth in two-dimensional and three-dimensional conditions. Strikingly, we define novel roles for axonal pathfinding receptors and ligands and the endothelin receptor in both growth and differentiation.
Separate and overlapping specificities in rheumatoid arthritis antibodies binding to citrulline- and homocitrulline-containing peptides related to type I and II collagen telopeptides
Authors: Turunen Sanna , Hannonen Pekka , Koivula Marja-Kaisa , Risteli Leila , Risteli Juha 
Published: January 2015

Abstract
Introduction
Our objective was to find out if there are antibodies binding to homocitrulline-containing type I and II collagen carboxyterminal telopeptides in sera of patients with rheumatoid arthritis (RA), and if these antibodies cross-react with citrulline and homocitrulline in the same peptide sequence.

Methods
A total of 72 RA and 72 control sera were analyzed for binding using enzyme-linked immunosorbent assay to citrulline- or homocitrulline-containing type I and II collagen carboxyterminal telopeptides, as well as to cyclic citrullinated peptide (CCP) and to mutated citrullinated vimentin (MCV). Specificities of the antibodies were tested using inhibition-ELISA.

Results
Of the RA sera, 39 (54%) and 41 (57%) were positive for binding to CCP and MCV, respectively. Further, 34 (47%) and 30 (42%) of the patients had specific antibodies binding to and being inhibited by citrulline-containing type I collagen telopeptides and by citrulline-containing type II collagen carboxyterminal telopeptides, respectively. The corresponding figures regarding homocitrulline-containing type I and homocitrulline-containing type II collagen telopeptides were 16 (22%) and 14 (19%). Most of the patients, who were seropositive for citrullinated peptides, showed binding in multiple assays. A total of 10 (14%) RA patients were positive for all the tested peptide pairs, while 28 (39%) of them had antibodies that contained overlapping specifities between citrulline and homocitrulline in the same peptide sequence.

Conclusions
Antibodies to both citrulline and homocitrulline containing type I and II collagen telopeptides can be found in sera of RA patients. These antibodies are not constant from one RA patient to another, but contain separate or overlapping specificities within the same peptide sequence varying between individuals. Our results suggest some relationship between citrulline and homocitrulline-recognizing antibodies, since homocitrulline antibodies exist mainly in individuals seropositive to anti-CCP and anti-MCV.
The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria
Authors: Delgado Tasco´n Julia , Adrian Jonas , Kopp Kathrin , Scholz Philipp , Tschan Mario P , Kuespert Katharina , Hauck Christof R 
Published: January 2015

Abstract
Human granulocytes express several glycoproteins of the CEACAM family. One family member, CEACAM3, operates as a single-chain phagocytic receptor, initiating the detection, internalization, and destruction of a limited set of gram-negative bacteria. In contrast, the function of CEACAM4, a closely related protein, is completely unknown. This is mainly a result of a lack of a specific ligand for CEACAM4. By generating chimeric proteins containing the extracellular bacteria-binding domain of CEACAM3 and the transmembrane and cytoplasmic part of CEACAM4 (CEACAM3/4) we demonstrate that this chimeric receptor can trigger efficient phagocytosis of attached particles. Uptake of CEACAM3/4-bound bacteria requires the intact ITAM of CEACAM4, and this motif is phosphorylated by Src family PTKs upon receptor clustering. Furthermore, SH2 domains derived from Src PTKs, PI3K, and the adapter molecule Nck are recruited and associate directly with the phosphorylated CEACAM4 ITAM. Deletion of this sequence motif or inhibition of Src PTKs blocks CEACAM4-mediated uptake. Together, our results suggest that this orphan receptor of the CEACAM family has phagocytic function and prompt efforts to identify CEACAM4 ligands.
Gas-phase Ozone Reactions with Z-3-Hexenal and Z-3-Hexen-1-ol: Formation Yields of OH Radical, Propanal, and Ethane
Authors: Uchida Risa , Sato Kei , Imamura Takashi 
Published: January 2015

Abstract
The formation yields of OH radical, propanal, and ethane from the reactions of ozone with Z-3-hexenal (3HA) and Z-3-hexen-1-ol (3HO) were measured under atmospheric conditions. These OH yields were determined to be 0.32 ± 0.07 for 3HA and 0.28 ± 0.06 for 3HO. The relative formation yield of the C2H5CHOO intermediate was estimated based upon the formation yields of propanal and ethane, which consistently suggested that C2H5CHOO is formed more efficiently from the O3 + 3HA reaction than from the 3HO reaction.
End Group Effect on Aggregation in Oriented Bisazomethine Dye Films on Aligned Poly(tetrafluoroethylene) Layers
Authors: Tanaka Toshihiko , Ishitobi Masamitsu , Aoyama Tetsuya , Matsumoto Shinya 
Published: January 2015

Abstract
Anisotropic molecular thin films have been prepared by depositing several bisazomethine dyes under vacuum through evaporation on aligned poly(tetrafluoroethylene) (PTFE) layers. Their anisotropy and spectra significantly depend on the double-end groups of dye molecules. Oriented J-aggregates, previously reported for diethylamino ends, also have been obtained for pyrrolidinyl and butoxy ends, whereas they have not been obtained for dimethylamino, dibutylamino, butyl, and methoxy ends. The aggregates from butoxy ends are remarkable for a substrate effect: they grow well on the layers by PTFE evaporation and rubbing whereas they do neither on friction transferred PTFE layers nor on glass.
The supernatural and post-war Thai cinema
Authors: Ainslie Mary 
Published: January 2015

Abstract
This article explores several productions from the lower-class and provincial ‘16mm era’ film form of post-war Thailand, a series of mass-produced live-dubbed films that drew heavily upon the supernatural animist belief systems that organized Thai rural village life. It will illustrate that such ghostly discourses interject liberally into the films’ diegesis and are associated particularly strongly with female characters at a time when gender roles are being renegotiated. Through textual analysis combined with historical data, the article explores the ways in which films such as Mae Nak Phra Khanong (1959) by Gomarchun, Nguu Phii (1966) by Saetthaaphakdee, Phii Saht Sen Haa (1969) by Pan Kam and Nang Prai Taa Nii (1967) by Nakarin therefore function as a means to negotiate the dramatic changes and wider context of social upheaval experienced by Thai viewers during this era, much of which was specifically connected to the post-war influx of American culture into Thailand.
Between subjugation and subversion: Ideological ambiguity in the cinematic Mae Nak of Thailand
Authors: Ng Andrew Hock Soon 
Published: January 2015

Abstract
Deploying Jan Assman’s notion of cultural memory, this article considers three adaptations of the Mae Nak myth in Thai cinema – Mae Nak Phra Khanong (1959) by Gomarchun, Winyan Rak Mae Nak Phra Khanong (1978) by Seney, and to a lesser extent Nang Nak (1999) by Nimibutr – as unofficial historical repositories that reflect the sociocultural and political shifts in Thailand during the last 50 years of the twentieth century. More specifically, I argue that the character of Nak, whose representation in Nimibutr’s version has been restored to the singularly superlative position she occupied in myth, is more ambiguous as a signifier in the 1959 version that reinforces the twin institutions of Buddhism and patriarchy, while subtly undermining them at the same time. This narrative equivocation, however, is altogether absent in 1978 version, in which Nak’s representation has undergone substantial devaluation possibly as a textual attempt to distance a contemporary, capitalist-driven Thailand from a past that it deems no longer usable or compatible with its ideological agenda.
From filth-ghost to Khmer-witch: Phi Krasue’s changing cinematic construction and its symbolism
Authors: Baumann Benjamin 
Published: January 2015

Abstract
Depicted as a floating woman’s head with drawn out and bloody entrails dangling beneath it, phi krasue is one of the most iconic uncanny creatures of Thai horror cinema. However, despite its position as one of Thailand’s most striking and well-known phi, there is very little research investigating this specific phenomenon. This is remarkable given the commonality of encounters with this uncanny being in ‘real life’ and the continuous presence of its ghostly images in popular cultural media. Relating empirical data gathered during anthropological fieldwork in a rural community of Thailand’s lower north-east to the analysis of two Thai ghost films that take this ghostly image as their main subject and narrative force this article argues that the knowledge of vernacular ghostlore is essential to decipher the cinematic representations’ full symbolism. Thai ghost films are produced for the ‘knowing spectator’ who has implicit knowledge of the cultural logics structuring ghostly classification in contemporary Thailand. This embodied knowledge allows Thai audiences to make sense of phi krasue’s ghostly image despite its cinematic transformation from ‘Filth Ghost’ to ‘Khmer Witch’. Based on Kristeva’s theory of abjection I will show that Thai audiences continue to see phi krasue first and foremost as uncanny ‘matter out of place’.
Staging the spectral: The border, haunting and politics in Mekong Hotel
Authors: Boehler Natalie 
Published: January 2015

Abstract
Mekong Hotel (2012) is an hour-long experimental film by Thai director Apichatpong Weerasethakul. Set in an old hotel overlooking the Mekong, and melding documentary and fictional modes, it interweaves a ghost story, a romance, memories of the region’s troubled history and discussions on its present-day state. The film is characterized by elements of fluidity and transgression that appear in its use of the supernatural, its setting near a border river, and its oscillating modes of film style and narration, while its ghost characters transgress the border between the living and the (un-)dead. This article explores the role of haunting in Mekong Hotel, in particular its connection with the setting of the Mekong region and the memory of its history. It argues that the ghosts in the film function as carriers of the memory of the region; they also reference older forms of cinema, namely, the vernacular horror genre of the Thai classical era and thus transport media history. Through analysis of several scenes of the film, I demonstrate that these spectral figures express repressed traumas and non-official, silenced witnessing of sensitive political issues, such as conflict along the Thai-Lao border, the 2011 floods and the construction of dams along the Mekong. By reflecting on their medial origin, they lay emphasis on a vernacular discourse and a regional point of view. The analysis is supported by allusion to other short films by the director that also centre on similar topics.
Crypto-cannibalism: Meat, murder and monstrosity in Tiwa Moeithasong’s The Meat Grinder
Authors: Balmain Colette 
Published: January 2015

Abstract
Tiwa Moeithaisong’s 2009 production Cheuuat Gaawn Chim/The Meat Grinder is representative of a new trend in Thai horror cinema, one that has benefited from ‘the influence of short film, documentary film, and low-budget art-house movies’ together with new international marketing strategies and initiatives. This new brand of horror cinema (2000s) indicates that ‘the consumption of fear has started to gain ground commercially and aesthetically’ in Thailand. However, even though it trades on the popularity of torture-porn or spectacle horror, The Meat Grinder is aesthetically much more art-house than grind-house in what is perhaps a deliberate attempt to attract both local and global audiences. This article contends that The Meat Grinder transcends the generic conventions associated with extreme cinema in order to offer a sustained critique of the dominant narratives of Thai identity. These are based upon an internal transition from pre-modern to modern society and have been constructed through a fictional, linear history in which modernity was a natural progression and was not imposed by the colonial Other as in most other South East Asian nations. Specifically, this critique is performed through the figuration of the woman-as-monster, whose deadly recipe for noodles with the tasty addition of human flesh, has been passed down from generation to generation of women through a series of temporal displacements and spatial convergences. I therefore suggest that The Meat Grinder evokes what Lim defines as ‘immiscible temporalities’ connected to the ‘persistence of supernaturalism’, utilizing in particular the ghostly figure of the dead daughter who haunts the present-day frame. Such ‘ghostly returns’ I argue subvert conventional understandings of time as linear, both outside and inside the cinematic frame, which are contained within the discourse of crypto-colonialism on which Thai nationalism is built, and offers a politicized interrogation of class, nationality and gender politics in contemporary Thailand.
Reviews
Authors: Buckley Chloe , Stevenson Carly 
Published: January 2015

Abstract
The Twilight of the Gothic, Joseph Crawford (2014) Cardiff: University of Wales Press, 368 pp., ISBN-10: 1783160640; ISBN-13: 9781783160648, h/bk, £85.00
Listen in Terror: British Horror Radio from the Advent of Broadcasting to the Digital Age, Richard J. Hand (2014) Manchester: Manchester University Press, 256 pp., ISBN: 9780719081484, h/bk, £70.00
Maori–Pasifika relations: A problematic paradox?
Authors: Meijl Toon Van 
Published: January 2015

Abstract
Maori people maintain ambiguous relations with the rest of the Pacific. Genealogical relationships continue to be celebrated in ongoing connections across a wide range of domains and discourses, but the colonial history of New Zealand has also turned Maori into a community of indigenous people that has been eclipsed by European settlers over the past two centuries. As a corollary, Maori are embroiled in an intense struggle for recognition of their proprietary rights as the indigenous people of the islands of New Zealand. Over the past few decades, campaigns for a comprehensive settlement of their colonial grievances have gathered some momentum since the Treaty of Waitangi was gradually recognized again in the 1970s and 1980s. The negotiations between Maori and the government about historical and social justice for the indigenous population, however, may to some extent be counterbalanced by the increasing number of migrants arriving in New Zealand, from Asia and the Pacific Islands.
In the current competition for scarce resources, Maori have consistently argued that within the New Zealand nation state the establishment of biculturalism should precede the development of multiculturalism, implying also that indigenous rights should prevail over those of settlers and migrants. The political dichotomy between Maori and Pacific Islanders raises the question to what extent it distorts historical and contemporary connections. This article explores the multiple histories and manifold relations between Maori and Pacific Islanders in the past and present in order to examine whether the paradox of historical connections and contemporary competition can be resolved.