bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost analysis error? Exploring issues relating to whole-life cost estimation in sustainable housing
Authors: Sloan Brian , Tokede Olubukola , Wamuziri Sam , Brown Andrew 
Published: March 2014

Purpose
– The main purpose of the study is to promote consideration of the issues and approaches available for costing sustainable buildings with a view to minimising cost overruns, occasioned by conservative whole-life cost estimates. The paper primarily looks at the impact of adopting continuity in whole-life cost models for zero carbon houses.

Design/methodology/approach
– The study embraces a mathematically based risk procedure based on the binomial theorem for analysing the cost implication of the Lighthouse zero-carbon house project. A practical application of the continuous whole-life cost model is developed and results are compared with existing whole-life cost techniques using finite element methods and Monte Carlo analysis.

Findings
– With standard whole-life costing, discounted present-value analysis tends to underestimate the cost of a project. Adopting continuity in whole-life cost models presents a clearer picture and profile of the economic realities and decision-choices confronting clients and policy-makers. It also expands the informative scope on the costs of zero-carbon housing projects.

Research limitations/implications
– A primary limitation in this work is its focus on just one property type as the unit of analysis. This research is also limited in its consideration of initial and running cost categories only. The capital cost figures for the Lighthouse are indicative rather than definitive.

Practical implications
– The continuous whole-life cost technique is a novel and innovative approach in financial appraisal […] Benefits of an improved costing framework will be far-reaching in establishing effective policies aimed at client acceptance and optimally performing supply chain networks.

Originality/value
– The continuous whole-life costing pioneers an experimental departure from the stereo-typical discounting mechanism in standard whole-life costing procedures.
Learning the lessons from banding appeals
Authors: Moreton Adam , Jackson Emma , Ahmed-Little Yasmin 
Published: March 2014

Purpose
– Designing and running robust junior doctor rotas is a challenging task and much previous advice has been based on consensus or anecdote. This paper aims to discern the most frequently occurring problems with trainee working patterns and produce evidence-based guidance for implementing and running contract-compliant rotas.

Design/methodology/approach
– A total of 35 secondary care trusts in North West England were invited to supply information on pay banding appeals requested under the New Deal junior doctor contract. Of these, 15 (43 per cent) participated with data from 35 appeals between 2004 and 2012. A thematic analysis was undertaken to discern the commonly occurring causes of contractual breaches.

Findings
– A total of 83 per cent (n=29/35) of appeals were based on data showing the rota to be non-compliant with the contract (band 3), with the remainder being compliant with the contract but not in keeping with the pay banding currently assigned. Inability to take adequate natural breaks was the most frequently cited cause of rota non-compliance. Where underlying reasons were given for breaches of hours/rest limits they clustered around 20 themes, the top four being poor or absent dialogue between HR and doctors, excessive workload, inappropriately timed ward rounds, and inadequate or non-existent bleep policies.

Originality/value
– This is the first analysis of banding appeals under the UK junior doctor contract. The findings show that problems with rotas cluster around specific themes. The authors provide recommendations to target these so as to avoid financially detrimental contract breaches and trainee dissatisfaction.
“The college is so different from anything I have done”. A study of the characteristics of Nottingham Recovery College
Authors: McGregor Jane , Repper Julie , Brown Helen 
Published: March 2014

Purpose
– This paper aims to describe the working of one of the first Recovery Colleges (RCs) and explore the defining characteristics.

Design/methodology/approach
– This study explores the ways in which an educational approach contributes to the process of recovery as observed in the Nottingham Recovery College (NRC). A mixed-method research design was adopted, combining interviews, observation and visual methods as well as analysis of quantitative data. The process contributed to the continuing development of “fidelity criteria”, or defining principles and key features, of the college.

Findings
– The NRC demonstrates the possibilities of offering an alternative approach within mental health services; one which is educationally rather than therapeutically informed. The design and operation of the college is informed by educational principles in the creation and execution of the curriculum. This is critically developed through processes of co-production and co-facilitation by those with professional and lived experience, supported by policy development, rigorous documentation and the creation of a supportive, but challenging culture and environment. Students are offered very real opportunities for involvement, progression and leadership within and beyond the college.

Research limitations/implications
– Whilst building on work on education in self-management, the RCs move beyond the transmission of information to create new relationships between mental health professionals and students (rather than “service users”) – and through this, the relationship between students and their “condition” appears to be transformed. Early evidence suggests the NRC also provides a model of interaction that is distinct in educational terms.

Practical implications
– There is significant interest nationally and internationally in the development and operation of RCs in England. RCs present a possibility of transformation in the lives of people with long-term mental health conditions, with outcomes such as greater confidence and hope for the future in addition to widening social networks and providing opportunities for progression. They are also important in the implementation of Recovery through organisational change and the remodelling of commissioning arrangements.

Originality/value
– This is the first paper to be presented for publication specifically on the NRC. There is currently little published research on RCs. These are unique (and varying) organisations which are creating considerable interest nationally and internationally. An exploration of their defining characteristics will feed into subsequent larger-scale research.
Product wheels to achieve mix flexibility in process industries
Authors: Wilson Shellyanne , Ali Nazma 
Published: March 2014

Purpose
– Mix flexibility is a critical manufacturing flexibility type needed to produce a company's range of products. Oftentimes, multiple products are produced on shared resources which require coordination mechanisms to ensure their effective utilization. This paper aims to explore the applicability of the product wheel concept as a coordination mechanism that can be used to manage shared resources in operational mix flexibility achievement in process industries.

Design/methodology/approach
– The product wheel concept is a construct from the theory of lean manufacturing adoption in process industries. This construct is applied as a sequencing coordination mechanism, where similar products are grouped together to run consecutively in a production schedule. A single case study is used to illustrate the development and evaluation of a product wheel design.

Findings
– The results show that the product wheel concept does achieve the aim of grouping similar products in the production schedule, and, as such, can be used to improve the production planning process through the reduction of the number of time-intensive changeovers without sacrificing product availability to meet customer demand. The product wheel, however, is not a mathematical optimization technique; but is instead a heuristic technique which requires the use of judgment and experience to achieve an optimal design.

Originality/value
– A theoretical contribution to the study of mix flexibility has been made, where the application of the product wheel construct presents a novel approach to the study of operational mix flexibility achievement, via the sequencing of products on shared manufacturing resources.
Examination of the roles played by brand love and jealousy in shaping customer engagement
Authors: Sarkar Abhigyan , Sreejesh S. 
Published: March 2014

Purpose
– The purpose of the present paper is to develop and validate a scale of romantic brand jealousy and to examine the role played by the brand love-jealousy framework on consumers' active engagement.

Design/methodology/approach
– In order to develop and validate the romantic brand jealousy scale the present study has employed Churchill's methodology. The study has used common factor analysis and structural equation modeling using LISREL 8.72.

Findings
– This research provides empirical evidence for a three-item romantic brand jealousy scale. The study results indicate that the romantic jealousy scale developed is valid and reliable. It also shows that in contrast to previous literature, wherein authors found that brand love would create customer engagement, the brand love-jealousy framework would act as a better mediator to create customer engagement and also to motivate the customer to purchase the brand.

Research limitations/implications
– This research was conducted in a specific country (India). It would be more robust if the scale developed by this study could be examined in the context of other countries.

Practical implications
– This study is expected to help managers to formulate a better marketing strategy to increase customer engagement using the proposed brand love-jealousy framework.

Originality/value
– This research adds value to the domain of consumer psychology research by proposing that brand jealousy needs to be created along with brand love in customer's mind to augment the level of active engagement.
A “family of cycles” – major and auxiliary business cycles
Authors: Jadevicius Arvydas , Huston Simon 
Published: March 2014

Purpose– The paper aims to discuss the major and auxiliary types of cycles found in the literature.Design/methodology/approach– The existence of cycles within economy and its sub-sectors has been studied for a number of years. In the wake of the recent cyclical downturn, interest in cycles has increased. To mitigate future risks, scholars and investors seek new insights for a better understanding of the cyclical phenomenon. The paper presents systematic review of the existing copious cyclical literature. It then discusses general characteristics and the key forces that produce these cycles.Findings– The study finds four major and eight auxiliary cycles. It suggests that each cycle has its own distinct empirical periodicity and theoretical underpinnings. The longer the cycles are the greater controversy which surrounds them.Practical implications– Cycles are monumental to a proper understanding of complex property market dynamics. Their existence implies that economies, whilst not deterministic, have a rhythm. Cyclical awareness can therefore advance property market participants.Originality/value– The paper uncovers four major and eight auxiliary types of cycles and argues their importance.
Asset Management of low-zero carbon technology in social housing
Authors: Kempton Jim 
Published: March 2014

Purpose
– Households account for 27 per cent of the UK's total CO2 emissions therefore addressing housing energy efficiency has become a priority. Low-zero carbon technologies (LZCTs) for both new-build and the existing housing stock are one mechanism to reduce CO2. A gap in previous research into the subject was identified – the ongoing maintenance or “Asset Management” of LZCTs. This is important, inefficient or ineffective Asset Management may have a negative impact on the sustainability of energy efficient housing stock from a number of perspectives, including physical, social and economic. This paper aims to discuss these issues.

Design/methodology/approach
– The research presents a sector based study of the English social housing sector with seven individual organisations (known as “Registered Social Landlords”) represented by senior Asset Management practitioners, providing the units of analysis. Semi-structured interviews were conducted to evaluate the past, current and future ability of the sector to successfully maintain LZCTs. The interviews were coded and a theme/sub-theme building process undertaken.

Findings
– The interview analysis yielded three main themes (Asset Management Planning, Maintenance Skills and Occupier Impacts) and 12 sub-themes. Some of these confirmed findings from the literature review but others had not been previously located including inter-departmental conflicts and occupiers taking responsibility for maintenance.

Originality/value
– A paucity of previous work specifically relating to Asset Management and LZCTs in the social housing sector was found. The findings should therefore be of interest to a wide range of stakeholders including registered providers, asset managers, surveyors, developers and policy makers.
The cultural significance of synchronicity for Jung and Pauli
Authors: Main Roderick 
Published: March 2014

AbstractThis paper considers the cultural significance of C.G. Jung's concept of synchronicity, as this was envisaged both by Jung himself and by the physicist Wolfgang Pauli, Jung's most important discussant in developing the concept. For both thinkers the principle of synchronicity was, above all, an attempt to develop an expanded, more holistic understanding of science. The paper argues, however, that their motives for proposing this development were not just, as might be expected, scientific, philosophical, and psychological (including personal), but also historical, social, political, and religious, and involved consideration of esoteric as well as mainstream currents of thought.
Feasibility of Pediatric Plasma Apheresis in Intensive Care Settings
Authors: Haque Anwarul , Sher Gul , Hoda Mehar , Moiz Bushra 
Published: March 2014

AbstractTherapeutic plasma apheresis or exchange (TPE) in the pediatric population is technically challenging. Moreover, there is generally an apprehension in using TPE in children compared to adults. Recently, usage of TPE has evolved and is now being used in heterogenous clinical conditions. Its usefulness is classified by the American Society for Apheresis (ASFA) into various categories ranging from I to IV. The objective of this paper was to review the procedure in context of clinical indications, complications and outcomes in children. For this purpose, we retrospectively reviewed all TPE procedures performed on inpatients of 3 to 16 years of age during a 6‐year period (2007–2012). A total of 130 procedures were performed on 28 patients (M : F ratio of 1:1) with median age (range) of 8.8 (4–16) years. All procedures were done using the continuous cell‐separator centrifugal method. Due to organ dysfunctions, the majority of procedures (N = 26 of 28 or 92% patients) were performed in the pediatric intensive care unit. Twenty‐three, four and one patient belonged to ASFA categories I, II and III, respectively. The most common indications were neurological disorders (N = 13 or 46.4%), comprised of Guillain–Barré syndrome (N = 10) and myasthenia gravis (N = 3). Hematological disorders (N = 10 or 35.7%) including thrombotic thrombocytopenic purpura‐hemolytic uremic syndrome were a close second. Complete recovery was seen in 23 patients (84%). Trivial adverse effects were observed in 18/130 (13.8%) procedures. Major complications including cardiac arrest, hypotension and transfusion‐related acute lung injury were observed in 5/130 or 3.8% of procedures. However, there was no procedure‐related death though five patients died during treatment due to underlying pathology. In conclusion, TPE is a safe and effective option in sick children for appropriate indications. An experienced staff with sound procedural skills is imperative for successful therapy.
Therapeutic Plasma Exchange in Glucocorticosteroid‐Unresponsive Patients With Clinically Isolated Syndrome
Authors: Ehler Johannes , Koball Sebastian , Sauer Martin , Hickstein Heiko , Mitzner Steffen , Benecke Reiner , Zettl Uwe K 
Published: March 2014

AbstractClinically Isolated Syndromes (CIS) summarize clinical features of possible multiple sclerosis (MS) as a first clinical event of the disease. Escalation therapy in CIS episodes comprises high dose glucocorticosteroid (GCS) treatment followed by therapeutic plasma exchange (TPE) in patients unresponsive to GCS. The aim of our study was to analyze TPE effects in CIS patients. Eleven GCS‐unresponsive patients exhibiting CIS were treated with TPE. A median of 5.0 (range 3–8) treatments were performed with a median exchange volume of 3.0 L (range 2.2–3.5 L). Standard diagnostic results in CIS patients were collected. In 10 out of 11 patients clinical improvement was observed. In Expanded Disability Status Scale (EDSS) Scoring, a commonly used score to assess disability in MS and CIS patients, significant improvement was shown as well. One patient was a non‐responder to TPE. Apheresis treatments were well tolerated in all patients. In the medical control of GCS‐unresponsive CIS episodes, TPE appears to be an effective and well‐tolerated treatment option. TPE response in CIS patients is comparable to TPE results in GCS‐unresponsive MS relapses. Further prospective studies are indicated.
Improved axenization method reveals complexity of symbiotic associations between bacteria and acanthamoebae
Authors: Lagkouvardos Ilias , Shen Jie , Horn Matthias 
Published: March 2014

SummaryBacteria associated with free‐living amoebae have attracted considerable attention because of their role in human disease and as models for studying endosymbiosis. However, the identification and analysis of such novel associations are hindered by the limitations of methods for isolation and axenization of amoebae. Here, we replaced the heat‐inactivated Escherichia coli, which is typically used as food source during axenization, with a live E. coli tolC knockout mutant strain hypersensitive to antibiotics. Together with the addition of otherwise sublethal amounts of ampicillin, this approach tripled the success rate and reduced the time required for axenization by at least 3 days. Using this method for two environmental samples, 10 Acanthamoeba strains were isolated, seven of which contained bacterial symbionts. In three cases, amoebae harbouring two phylogenetically distinct symbionts were recovered, supporting a more widespread occurrence of multi‐partner symbiotic associations among free‐living amoebae.
Controversies in the management of gastrointestinal stromal tumors
Authors: Yip Desmond , Zalcberg John , Ackland Stephen , Barbour Andrew P , Desai Jayesh , Fox Stephen , Kotasek Dusan , McArthur Grant , Smithers B Mark 
Published: March 2014

AbstractMajor advances in the medical treatment of gastrointestinal tumors (GISTs) have improved survival for both patients with advanced disease and those diagnosed with high‐risk primary tumors. The Consensus approaches to best practice management of gastrointestinal stromal tumors, published in this journal in 2008, provided guidance for the management of GIST to both clinicians and regulatory authorities. Since then, clinical trials have demonstrated the benefit of adjuvant imatinib in high‐risk patients, and mature data from advanced GIST studies suggest that a small but significant proportion of patients with advanced disease can achieve long‐term benefit with ongoing imatinib treatment. Other evolving management strategies include the controversial use of palliative or debulking surgery to improve outcomes in advanced GIST and the development of promising new multikinase inhibitors, such as regorafenib, which has established benefit in the third‐line setting. This review provides an update of recent developments in GIST management and discusses new controversies that these advances have generated.
Intensive chemotherapy and reduced‐intensity allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in elderly patients
Authors: Jackson Kathryn , Kennedy Glen , Mollee Peter , Marlton Paula , Morris Kirk 
Published: March 2014

AbstractAimsAcute myeloid leukemia (AML) incidence increases with age, yet treatment of elderly patients has reduced efficacy compared with younger patients and is often poorly tolerated. This retrospective study assessed the outcomes of older patients with AML treated with intensive chemotherapy with or without allogeneic hematopoietic stem cell transplantation (HSCT).MethodsWe identified all adult patients ≥60 years with newly diagnosed AML treated with induction chemotherapy at our institutions between February 1999 and July 2011. Institutional databases and medical records were used to collect information on baseline characteristics, chemotherapy protocols, response to therapy, relapse‐free survival (RFS) and overall survival (OS).ResultsThree hundred and forty‐five patients ≥60 years were diagnosed with AML, including 172 patients (49.9%) who received intensive induction chemotherapy. The median age of intensively treated patients was 66 years (range 60–83 years). Responses to one to two cycles of induction chemotherapy were complete remission (CR) in 70.3% of patients, refractory disease in 15.1% and induction death in 14.5%. At a median follow‐up of 22 months for survivors, intensive induction chemotherapy resulted in 3‐year RFS of 20.2%, and 3‐year OS of 24.0%. Seventeen patients (14.0% of patients in CR1) proceeded to allogeneic HSCT in first remission. These patients experienced 3‐year RFS of 63.5% and 3‐year OS of 77.5%.ConclusionIntensive induction chemotherapy for newly diagnosed AML in older patients is feasible and effective in a proportion of patients, and those selected for allogeneic transplantation in CR1 may experience particularly favorable survival outcomes.
Natural evolution of skin‐test sensitivity in patients with IgE‐mediated hypersensitivity to cephalosporins
Authors: Romano A. , Gaeta F. , Valluzzi R. L. , Zaffiro A. , Caruso C. , Quaratino D. 
Published: March 2014

AbstractThere are studies demonstrating that skin‐test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with IgE‐mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospectively in a 5‐year follow‐up 72 cephalosporin‐allergic patients. After the first evaluation, patients were classified into two groups according to their patterns of allergologic‐test positivity: to both penicillins and cephalosporins (group A), or only to cephalosporins (group B). Skin tests and serum‐specific IgE assays were repeated 1 year later and, in case of persistent positivity, 3 and 5 years after the first allergologic examination. Seven (43.7%) of the 16 subjects of group A and 38 (67.8%) of the 56 patients of group B became negative; one was lost to follow‐up. Patients of group B became negative sooner and more frequently than group A subjects.