bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volatile systematics in terrestrial igneous apatite: from microanalysis to decoding magmatic processes
Authors: Li Wei-Ran , Bernard Olivier , Utami Sri Budhi , Phua Marcus 
Published: July 2024

AbstractApatite has been recognized as a robust tool for the study of magmatic volatiles in terrestrial and extraterrestrial systems due to its ability to incorporate various volatile components and its common occurrence in igneous rocks. Most previous studies have utilized apatite to study individual magmatic systems or regions. However, volatile systematics in terrestrial magmatic apatite formed under different geological environments has been poorly understood. In this study, we filtered a large compilation of data for apatite in terrestrial igneous rocks (n > 20,000), categorized the data according to tectonic settings, rock types, and bulk-rock compositions, and conducted statistical analyses of the F–Cl–OH–S–CO2 contents (~ 11,000 data for halogen and less for other volatiles). We find that apatite from volcanic arcs preserves a high Cl signature in comparison to other tectonic settings and the median Cl contents differ between arcs. Apatite in various types and compositions of igneous rocks shows overlapping F–Cl–OH compositions and features in some rock groups. Specifically, apatite in kimberlite is characterized as Cl-poor, whereas apatite in plutonic rocks can contain higher F and lower Cl contents than the volcanic counterparts. Calculation using existing partitioning models indicates that apatite with a high OH (or F) content does not necessarily indicate a H2O-rich (or H2O-poor) liquid because it could be a result of high (or low) magma temperature. Our work may provide a new perspective on the use of apatite to investigate volatile behavior in magma genesis and evolution across tectonic settings, volatile recycling at subduction zones, and the volcanic-plutonic connection.
Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care
Authors: Tönges Lars , Buhmann Carsten , Eggers Carsten , Lorenzl Stefan , Warnecke Tobias ,   for the German Parkinson Guideline Group, Bähr Mathias , Becktepe Jos , Berg Daniela , Brockmann Kathrin , Ceballos-Baumann Andrés , Claßen Joseph , Deuschl Cornelius , Deuschl Günther , Dodel Richard , Ebersbach Georg , Eimeren Thilo , Fanciulli Alessandra , Fimm Bruno , Folkerts Ann-Kristin , Gausepohl Madeleine , Hasan Alkomiet , Hermann Wiebke , Hilker-Roggendorf Rüdiger , Höglinger Günter , Höllerhage Matthias , Hopfner Franziska , Jost Wolfgang , Kalbe Elke , Kassubek Jan , Klebe Stephan , Klein Christine , Klietz Martin , Köglsperger Thomas , Kühn Andrea , Krack Paul , Krismer Florian , Kuhlenbäumer Gregor , Levin Johannes , Liepelt-Scarfone Inga , Lingor Paul , Loewenbrück Kai , Löhle Matthias , Maaß Sylvia , Maetzler Walter , Menzel Regina , Meyer Philipp T , Mollenhauer Brit , Neumann Manuela , Odin Per , Outeiro Tiago , Pötter-Nerger Monika , Reese René , Reetz Kathrin , Rieß Olaf , Ruf Viktoria , Schneider Anja , Schrader Christoph , Schnitzler Alfons , Seppi Klaus , Sixel-Döring Friederike , Storch Alexander , Trenkwalder Claudia , Eimeren Thilo , Walter Uwe , Wächter Tobias , Wegner Florian , Winkler Christian , Witt Karsten , Woitalla Dirk , Zeuner Kirsten 
Published: July 2024

Abstract
Introduction
In 2023, the German Society of Neurology published a new guideline on Parkinson’s disease. An important section dealt with PD care concepts, which represent a particularly dynamic field of PD research, including their implementation in clinical practice. Parkinson’s disease is the second most common age-associated neurodegenerative disease. Current estimates of the number of cases in the population describe a significant increase in prevalence in Germany by 2030 with higher proportions in rural areas, which also have a lack of sufficient PD care resources.

Recommendations
In comparison with other international guidelines, which have so far mentioned palliative care and Parkinson’s nurses in particular, the German S2k guideline expands the recommended concepts of PD care to include PD day clinics, inpatient complex treatment, and PD networks.

Conclusion
Concepts of PD care guidelines are necessary because of the complex and rapidly evolving field of PD care provision. If applied appropriately, the potential for optimized care can be exploited and both the patient burden and the economic burden can be reduced. Given that modern care concepts have so far only been applied in a few regions, it is often impossible to generate broad evidence-based data, so that the evaluation of PD care concepts is partly dependent on expert opinion.
The impact of mechanical stress on anatomy, morphology, and gene expression in Urtica dioica L.
Authors: Zajączkowska Urszula , Dmitruk Dominika , Sekulska-Nalewajko Joanna , Gocławski Jarosław , Dołkin-Lewko Alicja , Łotocka Barbara 
Published: July 2024

Abstract
Main conclusion
Mechanical stress induces distinct anatomical, molecular, and morphological changes in Urtica dioica, affecting trichome development, gene expression, and leaf morphology under controlled conditions

Abstract
The experiments were performed on common nettle, a widely known plant characterized by high variability of leaf morphology and responsiveness to mechanical touch. A specially constructed experimental device was used to study the impact of mechanical stress on Urtica dioica plants under strictly controlled parameters of the mechanical stimulus (touching) and environment in the growth chamber. The general anatomical structure of the plants that were touched was similar to that of control plants, but the shape of the internodes' cross section was different. Stress-treated plants showed a distinct four-ribbed structure. However, as the internodes progressed, the shape gradually approached a rectangular form. The epidermis of control plants included stinging, glandular and simple setulose trichomes, but plants that were touched had no stinging trichomes, and setulose trichomes accumulated more callose. Cell wall lignification occurred in the older internodes of the control plants compared to stress-treated ones. Gene analysis revealed upregulation of the expression of the UdTCH1 gene in touched plants compared to control plants. Conversely, the expression of UdERF4 and UdTCH4 was downregulated in stressed plants. These data indicate that the nettle's response to mechanical stress reaches the level of regulatory networks of gene expression. Image analysis revealed reduced leaf area, increased asymmetry and altered contours in touched leaves, especially in advanced growth stages, compared to control plants. Our results indicate that mechanical stress triggers various anatomical, molecular, and morphological changes in nettle; however, further interdisciplinary research is needed to better understand the underlying physiological mechanisms.
Effects of different types of leisure activities on working memory across the adult lifespan
Authors: Cansino Selene , Torres-Trejo Frine , Estrada-Manilla Cinthya , Ruiz-Velasco Silvia 
Published: July 2024

AbstractThe aim of the present study was to contrast the potential influence of five independent types of leisure activities (physical, mental, social, cultural, and passive) on working memory in a lifespan sample and in specific stages of adulthood (young, middle-aged, and older adults). A sample of 1652 healthy adults between 21 and 80 years of age participated in the study. Leisure activities were assessed through a lifestyle questionnaire created for the study. Working memory was measured in the verbal and spatial domains using a computerized n-back task that allowed us to reliably measure discrimination and reaction times. Across adulthood, mental (computer use and hobbies) and social leisure activities predicted greater verbal and spatial working memory discrimination; mental (reading) and social activities predicted faster verbal working memory; and mental (computer use) and physical activities predicted faster spatial working memory. In young adults, mental (computer use) and social activities were associated with greater verbal and spatial working memory performance. In middle-aged adults, physical and mental activities (computer use) were associated with greater working memory performance. In older adults, physical, mental (hobbies), and social activities were associated with greater working memory performance. Leisure activities can enhance working memory discrimination and speed independent of individuals’ age.
Integrating brain function and structure in the study of the human attentional networks: a functionnectome study
Authors: Martín-Signes Mar , Paz-Alonso Pedro M. , Thiebaut de Schotten Michel , Chica Ana B. 
Published: July 2024

AbstractAttention is a heterogeneous function theoretically divided into different systems. While functional magnetic resonance imaging (fMRI) has extensively characterized their functioning, the role of white matter in cognitive function has gained recent interest due to diffusion-weighted imaging advancements. However, most evidence relies on correlations between white matter properties and behavioral or cognitive measures. This study used a new method that combines the signal from distant voxels of fMRI images using the probability of structural connection given by high-resolution normative tractography. We analyzed three fMRI datasets with a visual perceptual task and three attentional manipulations: phasic alerting, spatial orienting, and executive attention. The phasic alerting network engaged temporal areas and their communication with frontal and parietal regions, with left hemisphere dominance. The orienting network involved bilateral fronto-parietal and midline regions communicating by association tracts and interhemispheric fibers. The executive attention network engaged a broad set of brain regions and white matter tracts connecting them, with a particular involvement of frontal areas and their connections with the rest of the brain. These results partially confirm and extend previous knowledge on the neural substrates of the attentional system, offering a more comprehensive understanding through the integration of structure and function.
UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway
Authors: He Li , Chen Heng , Ruan Bin , He Li , Luo Ming , Fu Yulun , Zou Rui 
Published: July 2024

Abstract
Background
Ubiquilin-4 (UBQLN4), a member of the ubiquilin family, has received limited attention in cancer research to date. Here, we investigated for the first time the functional role and mechanism of UBQLN4 in non-small cell lung cancer (NSCLC).

Methods
The Cancer Genome Atlas (TCGA) database was employed to validate UBQLN4 as a differentially expressed gene. Expression differences of UBQLN4 in NSCLC cells and tissues were assessed using immunohistochemistry (IHC) experiment and western blotting (WB) experiment. Kaplan-Meier analysis was conducted to examine the association between UBQLN4 expression and NSCLC prognosis. Functional analyses of UBQLN4 were performed through cell counting kit-8 (CCK-8), colony formation, and transwell invasion assays. The impact of UBQLN4 on tumor-associated signaling pathways was assessed using the path scan intracellular signaling array. In vivo tumorigenesis experiments were conducted to further investigate the influence of UBQLN4 on tumor formation.

Results
UBQLN4 exhibited up-regulation in both NSCLC tissues and cells. Additionally, over-expression of UBQLN4 was associated with an unfavorable prognosis in NSCLC patients. Functional loss analyses demonstrated that inhibiting UBQLN4 could suppress the proliferation and invasion of NSCLC cells in both in vitro and in vivo settings. Conversely, functional gain experiments yielded opposite results. Path scan intracellular signaling array results suggested that the role of UBQLN4 is associated with the PI3K/AKT pathway, a correlation substantiated by in vitro and in vivo tumorigenesis experiments.

Conclusion
We validated that UBQLN4 promotes proliferation and invasion of NSCLC cells by activating the PI3K/AKT pathway, thereby facilitating the progression of NSCLC. These findings underscore the potential of targeting UBQLN4 as a therapeutic strategy for NSCLC.
Single-centre real-life observational study on mortality and outcomes: decompressive craniectomy and brain death in traumatic brain injury, haemorrhage, and other cerebral diseases
Authors: Schröder Isabelle , Güresir Erdem , Vatter Hartmut , Soehle Martin 
Published: July 2024

Abstract

Background
Decompressive hemicraniectomy (DHC) is used after severe brain damages with elevated, refractory intracranial pressure (ICP). In a non age-restricted population, mortality rates and long-term outcomes following DHC are still unclear. This study’s objectives were to examine both, as well as to identify predictors of unfavourable outcomes.

Methods
We undertook a retrospective observational analysis of patients aged 18 years and older who underwent DHC at the University Hospital of Bonn between 2018 and 2020, due to traumatic brain injury (TBI), haemorrhage, tumours or infections. Patient outcomes were assessed by conducting telephone interviews, utilising questionnaires for modified Rankin Scale (mRS) and extended Glasgow Outcome scale (GOSE). We evaluated the health-related quality of life using the EuroQol (EQ-5D-5L) scale.

Results
A total of 144 patients with a median age of 58.5 years (range: 18 to 85 years) were evaluated. The mortality rate was 67%, with patients passing away at a median of 6.0 days (IQR [1.9–37.6]) after DHC. Favourable outcomes, as assessed by the mRS and GOSE were observed in 10.4% and 6.3% of patients, respectively. Cox regression analysis revealed a 2.0% increase in the mortality risk for every year of age (HR = 1.017; 95% CI [1.01–1.03]; p = 0.004). Uni- and bilateral fixed pupils were associated with a 1.72 (95% CI [1.03–2.87]; p = 0.037) and 3.97 (95% CI [2.44–6.46]; p < 0.001) times higher mortality risk, respectively. ROC-analysis demonstrated that age and pupillary reactivity predicted 6-month mortality with an AUC of 0.77 (95% CI [0.69–0.84]). The only parameter significantly associated with a better quality of life was younger age.

Conclusions
Following DHC, mortality remains substantial, and favourable outcomes occur rarely. Particularly in elderly patients and in the presence of clinical signs of herniation, mortality rates are notably elevated. Hence, the indication for DHC should be set critically.
Modelling the quantification of requirements technical debt
Authors: Perera Judith , Tempero Ewan , Tu Yu-Cheng , Blincoe Kelly 
Published: July 2024

AbstractRequirements Technical Debt (RTD) applies the Technical Debt (TD) metaphor to capture the consequences of sub-optimal decisions made concerning Requirements. Understanding the quantification of RTD is key to its management. To facilitate this understanding, we developed a conceptual model, the Requirements Technical Debt Quantification Model (RTDQM). Our work is grounded in the literature found via a systematic mapping study and informed by prior work modeling the quantification of software code-related TD types. The key finding is that although RTD is similar to code-related TD in many aspects, it also has its own components. RTD can be incurred regardless of the presence of code-related TD. Unlike code-related TD, RTD has a feedback loop involving the user. RTD can have a cascading impact on other development activities, such as design and implementation, apart from the extra costs and efforts incurred during requirements engineering activities; this is modeled by the RTD Interest constituents in our model. The model was used to compare and analyze existing quantification approaches. It helped identify what RTD quantification concepts are discussed in the existing approaches and what concepts are supported by metrics for their quantification. The model serves as a reference for practitioners to select existing or to develop new quantification approaches to support informed decision-making for RTD management.
Late adolescent outcomes of different developmental trajectories of ADHD symptoms in a large longitudinal study
Authors: Carter Lara , Speyer Lydia , Caye Arthur , Rohde Luis , Murray Aja Louise 
Published: July 2024

Abstract
There exists substantial heterogeneity in the developmental trajectories of ADHD symptoms, with distinctions often made between persistent versus remittent, and early- versus late-onset. However, how these trajectories relate to late adolescent functioning and whether, in particular, later onset trajectories mark a milder subtype remains unclear. Building on earlier work that has examined early life predictors of ADHD symptom trajectories up to age 14, we applied latent class growth analysis to data from the UK Millennium Cohort Study (N = 10,262) to evaluate whether developmental trajectories of ADHD symptoms up to age 17 (from age 3) were similar to those identified up to age 14 and associated with differing levels of impairment in peer victimisation, mental health, substance use, and delinquency outcomes at age 17. Our optimal model included five trajectory groups, labelled unaffected (37.6%), mildly affected (34.8%), subclinical remitting (14.4%), adolescent onset (7.6%), and stable high (5.6%). Adolescent onset and stable high trajectories were similarly impaired across all outcomes, other than substance use. Subclinical remitting individuals were impaired on self-esteem and well-being compared to unaffected individuals. By the end of mid-adolescence, those with a later onset have similar impairments to those following an early onset/persistent trajectory. Residual impairment may remain for those on a remitting trajectory.
Simulating the Appearance of Aerial Images formed by Aerial Imaging by Retroreflection
Authors: Saito Asahi , Yue Yonghao , Koizumi Naoya 
Published: July 2024

AbstractRay tracing, combined with ideal retroreflection and mathematical simulation methods, has been used to design aerial imaging systems based on retroreflection. Although aerial images are blurred and have lower brightness than the light source, existing simulation methods do not focus on the appearance of these characteristics. In this study, we propose a computer graphics (CG)-based simulation using the ray tracing method to generate CG renditions of aerial images with reproduced luminance and blurring. CG models of three optical elements (light source, half-mirror, and retroreflector) were created on the basis of existing optical element models to simulate aerial images obtained through retroreflection in aerial imaging systems. By measuring the image formation positioning, we determined that the rendered aerial images consistently formed at a plane-symmetrical position relative to the axis of the half-mirror model, with a mean absolute error of $${0.55\,\textrm{mm}}$$

0.55

mm

. We also compared rendered and actual aerial images in terms of luminance and sharpness characteristics, and found that the mean absolute percentage error of luminance remained within $$0.0376$$

0.0376

. Furthermore, the directional dependence of blur was effectively reproduced using the retroreflector bidirectional reflectance distribution function developed in this study.
Robot remote control using virtual reality headset: studying sense of agency with subjective distance estimates
Authors: Yashin Artem S. , Lavrov Daniil S. , Melnichuk Eugeny V. , Karpov Valery V. , Zhao Darisy G. , Dubynin Ignat A. 
Published: July 2024

AbstractMobile robots have many applications in the modern world. The autonomy of robots is increasing, but critical cases like search and rescue missions must involve the possibility of human intervention for ethical reasons and safety. To achieve effective human–robot interaction, the operator needs to have a sense of agency (SoA) over the activities of the robot. One possible way to increase one's SoA in remote control could be the use of VR technology. The remote control situation has some important features, so indicators of SoA need to be reproduced there independently. In our study, participants controlled a mobile robot using either a monitor or a VR-headset as an output device. In both cases, active control was contrasted with passive observation of the robot's movement. In each trial, participants estimated the distance traveled by the robot—a putative implicit indicator of SoA. A significant difference between subjective distance estimates was found in the active and passive conditions with the monitor, but not in the active and passive conditions with VR. The effect obtained in the monitor conditions suggests that distance estimates can be used as an implicit indicator of SoA in robot remote control. We believe that the lack of difference between the active and passive conditions in VR was caused by motion sickness due to a mismatch of visual and vestibular sensory cues, leading to a weakened SoA.
Analyzing resilient attention management of expert operators using functional resonance analysis method
Authors: Yasue Naruki , Sawaragi Tetsuo 
Published: July 2024

AbstractManufacturing worksites have developed to have a socio-technical aspect with complex interactions between human operators, automated machines, and the environment. The operators must adapt to and cope with daily performance variabilities in these socio-technical systems to maintain resilient productions. However, more than conventional methods are needed to clarify the operators’ adaptive aspects that interactive factors play a critical role. This study investigates attention management in multitasking as one crucial aspect of the adaptive behavior of manual operations in actual manufacturing worksites. The framework considering the functional structure of tacit knowledge was employed for this purpose. Data from a case study focusing on multitasking in steel plate processing was utilized. First, we extracted the attention characteristics with eye movement and interview analysis regarding the proximal and distal terms of tacit knowledge. Then, we took a model constructive approach using work domain analysis (WDA) and functional resonance analysis method (FRAM). The results showed that the expert operator could maintain the systematic attention strategy even when multitasking. Furthermore, the simulation results showed that extracted experts’ attention strategy contributed to the resilient work performance. The current study confirmed that the framework based on FRAM could investigate the adaptive nature of expert skills in socio-technical systems.