bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted interventions for patellofemoral pain syndrome (TIPPS): classification of clinical subgroups
Authors: Selfe James , Callaghan Michael , Witvrouw Erik , Richards James , Dey Maria Paola , Sutton Chris , Dixon John , Martin Denis , Stokes Maria , Janssen Jessie , Ritchie Elizabeth , Turner David 
Published: September 2013

IntroductionPatellofemoral pain (PFP) can cause significant pain leading to limitations in societal participation and physical activity. An international expert group has highlighted the need for a classification system to allow targeted intervention for patients with PFP; we have developed a work programme systematically investigating this. We have proposed six potential subgroups: hip abductor weakness, quadriceps weakness, patellar hypermobility, patellar hypomobility, pronated foot posture and lower limb biarticular muscle tightness. We could not uncover any evidence of the relative frequency with which patients with PFP fell into these subgroups or whether these subgroups were mutually exclusive. The aim of this study is to provide information on the clinical utility of our classification system.Methods and analysis150 participants will be recruited over 18 months in four National Health Services (NHS) physiotherapy departments in England. Inclusion criteria: adults 18–40 years with PFP for longer than 3 months, PFP in at least two predesignated functional activities and PFP elicited by clinical examination. Exclusion criteria: prior or forthcoming lower limb surgery; comorbid illness or health condition; and lower limb training or pregnancy. We will record medical history, demographic details, pain, quality of life, psychomotor movement awareness and knee temperature. We will assess hip abductor and quadriceps weakness, patellar hypermobility and hypomobility, foot posture and lower limb biarticular muscle tightness.The primary analytic approach will be descriptive. We shall present numbers and percentages of participants who meet the criteria for membership of (1) each of the subgroups, (2) none of the subgroups and (3) multiple subgroups. Exact (binomial) 95% CIs for these percentages will also be presented.Ethics and disseminationThis study has been approved by National Research Ethics Service (NRES) Committee North West—Greater Manchester North (11/NW/0814) and University of Central Lancashire (UCLan) Built, Sport, Health (BuSH) Ethics Committee (BuSH 025). An abstract has been accepted for the third International Patellofemoral Pain Research Retreat, Vancouver, September 2013.
Bowing, kneeling and ‘prostration’: athlete's collapse patterns during sudden cardiac arrhythmia/arrest on the field of play
Authors: Baltsezak Stanislav 
Published: September 2013

BackgroundSudden cardiac arrest (SCA) on the field of play remains one of the most tragic and challenging events for a team physician. Even with robust regular preparticipation cardiac screening we cannot prevent all cases of SCA. Ability to recognise imminent cardiac arrest occurring on the field of play remains an important step in managing this condition without delay.MethodsYou Tube was searched for video clips clearly depicting the sequence of an athlete's collapse of cardiac origin. A pattern of collapse was subsequently analysed.Results13 cases were available for public viewing on You Tube and demonstrated the final position of collapse. 12 collapses had full video footage of athlete's fall. All athletes were men. 84.6% (11) cases were from football (soccer). 15.4% (2) of cases were from martial arts. In 10 out of 12 cardiac event cases (83.3%) bowing and/or kneeling were followed by decubitus position. 58.3% (7) of cases demonstrated bowing at the beginning of collapse. 58.3% (7) cases had kneeling as an element of collapse. 61.5% (8 out of 13 cases) of casualties adopted position of ‘prostration’ (ie, prone) as final stage of collapse.ConclusionsWhen on the field of play, in the absence of head injury, athletes displaying bowing and/or kneeling positions followed by collapse should be assumed to have a life-threatening cardiac event. Final position of ‘prostration’ was adopted in over half of cardiogenic collapses. A sports medicine professional should bear this in mind and target his/her assessment and treatment accordingly. When attending such casualties, a defibrillator must be taken to the collapsed player.
The impact of pedestrian countdown signals on pedestrian-motor vehicle collisions: a reanalysis of data from a quasi-experimental study
Authors: Richmond Sarah A , Willan Andrew R , Rothman Linda , Camden Andi , Buliung Ron , Macarthur Colin , Howard Andrew 
Published: September 2013

ObjectiveTo perform a more sophisticated analysis of previously published data that advances the understanding of the efficacy of pedestrian countdown signal (PCS) installation on pedestrian-motor vehicle collisions (PMVCs), in the city of Toronto, Canada.MethodsThis is an updated analysis of the same dataset from Camdenet al. A quasi-experimental design was used to evaluate the effect of PCS on PMVC. A Poisson regression analysis, using a one-group comparison of PMVC, pre-PCS installation to post-PCS installation was used, controlling for season and temporal effects. The outcome was the frequency of reported PMVC (January 2000–December 2009). Similar models were used to analyse specific types of collisions defined by age of pedestrian, injury severity, and pedestrian and vehicle action. Incidence rate ratios with 95% CI are presented.ResultsThis analysis included 9262 PMVC, 2760 during or after PCS installation, at 1965 intersections. There was a 26% increase in the rate of collisions, pre to post-PCS installation (incidence rate ratio=1.26, 95% CI 1.11 to 1.42).ConclusionsThe installation of PCS at 1965 signalised intersections in the city of Toronto resulted in an increase in PMVC rates post-PCS installation. PCSs may have an unintended consequence of increasing pedestrian-motor vehicle collisions in some settings.
Tectonic reconstruction and sediment provenance of a far-travelled oceanic nappe, Helgeland Nappe Complex, west-central Norway
Authors: McArthur Kelsey L. , Frost Carol D. , Barnes Calvin G. , Prestvik Tore , Nordgulen Øystein 
Published: September 2013

Abstract

The Helgeland Nappe Complex (HNC), part of the Uppermost Allochthon of the north-central Norwegian Caledonides, originated near the Laurentian margin and was transferred to Baltica during the closure of Iapetus in Late Silurian–Early Devonian time. The islands of Rødøy, Bolvær and Leka, located in the Sauren–Torghatten (S–T) nappe of the HNC, are composed of ultramafic and mafic basement rocks unconformably overlain by metaconglomerates and fine-grained metasedimentary rocks. Geochemical and isotopic characteristics of the basement rocks are consistent with formation in a supra-subduction zone setting. Overlying metasedimentary rocks record an increasing proportion of continental detritus supplied to the basins through time. Precambrian cratonic source regions supplied cobbles and other detritus. This source area may have been located in modern SE Greenland/Labrador or in the Lower Nappe of the HNC. The second alternative best accounts for the short transport distances required by the coarse-grained conglomerates. The maximum age of deposition is constrained by the age of the youngest zircon grain dated at 471±8 Ma. Final sedimentation, nappe thrusting and nappe stacking occurred in rapid succession during
c.
480–475 Ma.

Supplementary material:

Geochemical analyses and Nd isotopic data are available at
http://www.geolsoc.org.uk/SUP18654
.
Risk of Coronary Artery Compression Among Patients Referred for Transcatheter Pulmonary Valve Implantation
Authors: Morray Brian H. , McElhinney Doff B. , Cheatham John P. , Zahn Evan M. , Berman Darren P. , Sullivan Patrick M. , Lock James E. , Jones Thomas K. 
Published: September 2013

Background—
The Melody transcatheter pulmonary valve (TPV) was approved for implantation in obstructed right ventricular outflow tract conduits in 2010 after a multicenter trial demonstrating improvements in conduit obstruction, regurgitation, and right ventricular pressure. A recognized risk and contraindication to TPV implantation is the demonstration of coronary artery (CA) compression during balloon angioplasty or stent placement in the overlying conduit. This study is the first to characterize the risk of CA compression in this population.

Methods and Results—
From 2007 to 2012, 404 patients underwent 407 catheterizations for potential TPV implantation (median age, 18 years) at 4 centers. Three hundred forty-three patients (85%) underwent valve implantation. Twenty-one patients (5%) had evidence of CA compression with simultaneous right ventricular outflow tract angioplasty and CA angiography. Sixty-eight patients (17%) had abnormal CA anatomy. Fifteen of 21 (71%) patients with CA compression had abnormal CA anatomy. Eight patients with tetralogy of Fallot and 7 patients with transposition of the great arteries demonstrated compression. Of the 34 patients with tetralogy of Fallot and abnormal CA, 7 (21%) demonstrated CA compression.

Conclusions—
CA compression following TPV implantation can be catastrophic. CA compression was observed in 5% of patients during test balloon angioplasty. No patients in this study developed clinically apparent CA compression after TPV implantation. CA compression was significantly associated with the presence of abnormal CA anatomy, especially in patients with tetralogy of Fallot or transposition of the great arteries. Preimplantation coronary angiography with simultaneous test angioplasty is an important step to evaluate for the presence of CA compression during TPV implantation.
Excimer Laser–Assisted Removal of Embedded Inferior Vena Cava Filters
Authors: Kuo William T. , Odegaard Justin I. , Rosenberg Jarrett K. , Hofmann Lawrence V. 
Published: September 2013

Background—
Although chronically implanted inferior vena cava filters may result in filter-related morbidity, there is currently no routine option for removing such filters when they become firmly embedded along the vena cava endothelium.

Methods and Results—

During a 3-year period, 100 consecutive patients were prospectively enrolled in a single-center study. There were 42 men and 58 women (mean age, 46 years; limits, 18–76 years). Retrieval indications included filter-related acute inferior vena cava thrombosis, chronic inferior vena cava occlusion, and pain from retroperitoneal or bowel penetration. Filter retrieval was also performed to prevent risks from prolonged implantation and to potentially eliminate the need for lifelong anticoagulation. After standard methods failed, photothermal tissue ablation was attempted with a laser sheath powered by a 308-nm xenon chloride excimer laser. Applied forces were recorded with a digital tension meter before and during laser activation. Laser-assisted retrieval was successful in 98.0% (95% confidence interval [CI], 93.0%–99.8%) with mean implantation of 855 days (limits, 37–6663 days; >18 years). The following filter types were encountered in this study: Günther-Tulip (n=34), Celect (n=12), Option (n=17), Optease (n=20, 1 failure), TrapEase (n=6, 1 failure), Simon-Nitinol (n=1), 12F Stainless Steel Greenfield (n=4), and Titanium Greenfield (n=6). The average force during failed standard retrievals was 7.2 versus 4.6 pounds during laser-assisted retrievals (
P
<0.0001). The major complication rate was 3.0% (95% CI, 0.6%–8.5%), the minor complication rate was 7.0% (95% CI, 0.3%–13.9%), and there were 4 adverse events (2 coagulopathic hemorrhages, 1 renal infarction, and 1 cholecystitis; 4.0%; 95% CI, 1.1%–9.9%) at mean follow-up of 500 days (limits, 84–1079 days). Scar tissue ablation was histologically confirmed in 96.0% (95% CI, 89.9%–98.9%). Successful retrieval allowed cessation of anticoagulation in 30 of 30 (100%) patients and alleviated morbidity in 23 of 24 patients (96%).

Conclusions—
Excimer laser–assisted removal is effective in removing embedded inferior vena cava filters refractory to standard retrieval and high force. This method can be safely used to prevent and alleviate filter-related morbidity.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01158482.
Burden and Outcome of Prevalent Ischemic Brain Disease in a National Acute Stroke Registry
Authors: Koton Silvia , Tsabari Rakefet , Molshazki Noa , Kushnir Moshe , Shaien Radi , Eilam Anda , Tanne David 
Published: September 2013

Background and Purpose—
Previous overt stroke and subclinical stroke are frequent in patients with stroke; yet, their clinical significance and effects on stroke outcome are not clear. We studied the burden and outcome after acute ischemic stroke by prevalent ischemic brain disease in a national registry of hospitalized patients with acute stroke.

Methods—
Patients with ischemic stroke in the National Acute Stroke Israeli prospective hospital-based registry (February to March 2004, March to April 2007, and April to May 2010) with information on previous overt stroke and subclinical stroke per computed tomography/MRI (n=3757) were included. Of them, a subsample (n=787) was followed up at 3 months. Logistic regression models were computed for outcomes in patients with prior overt stroke or subclinical stroke, compared with patients with first stroke, adjusting for age, sex, vascular risk factors, stroke severity, and clinical classification.

Results—
Two-thirds of patients had a prior overt stroke or subclinical stroke. Death rates were similar for patients with and without prior stroke. Adjusted odds ratios (OR; 95% confidence interval [CI]) for disability were increased for patients with prior overt stroke (OR, 1.31; 95% CI, 1.03–1.66) and subclinical stroke (OR, 1.45; 95% CI, 1.16–1.82). Relative odds of Barthel Index ≤60 for patients with prior overt stroke (OR, 2.04; 95% CI, 1.14–3.68) and with prior subclinical stroke (OR, 2.04; 95% CI, 1.15–3.64) were twice higher than for patients with a first stroke. ORs for dependency were significantly increased for patients with prior overt stroke (OR, 1.95; 95% CI, 1.19–3.20) but not for those with subclinical stroke (OR, 1.36; 95% CI, 0.84–2.19).

Conclusions—
In our national cohort of patients with acute ischemic stroke, nearly two thirds had a prior overt stroke or subclinical stroke. Risk of poor functional outcomes was increased for patients with prior stroke, both overt and subclinical.
A new gecko from Libya: Tarentola neglecta lanzai n. ssp.
Authors: Bshaena Ismail , Joger Ulrich 
Published: September 2013

New findings from two Central Libyan oases extend the distribution area of the Saharan gecko Tarentola neglecta considerably to the East. Scale counts falling outside the range of the two known subspecies show that the new specimens belong to a third subspecies which is described here under the name Tarentola neglecta lanzai. A molecular phylogeny with mitochondrial genes presents further evidence that T. neglecta is the sister species of the Egyptian T. mindiae, both of which constitute a monophyletic clade within the T. fascicularis-deserti group.
On the Deceiving Aspects of Mixing Diagrams of Deep Cumulus Convection
Authors: Böing Steven J. , Jonker Harm J. J. , Nawara Witek A. , Siebesma A. Pier 
Published: September 2013

Abstract
Mixing processes in deep precipitating cumulus clouds are investigated by tracking Lagrangian particles in a large-eddy simulation. The trajectories of particles are reconstructed and the thermodynamic properties of cloud air are studied using mixing diagrams. The trajectory analysis shows that the in-cloud mixing is entirely dominated by lateral entrainment and that there is no significant vertical mixing by downdrafts originating from cloud top. Yet the thermodynamic properties of the particles are located close to a line in the mixing diagrams, which appears to be consistent with two-point vertical mixing. An attempt is made to resolve this paradox using the buoyancy-sorting model of Taylor and Baker, but it is found that this model does not provide a full explanation for the location of particles in the mixing diagram. However, it is shown that the mixing-line behavior can be well understood from a simple analytically solvable model that uses a range of different lateral entrainment rates. Two further factors that determine the location of particles in the mixing diagram are identified: the removal of noncloudy air and precipitation effects. Finally, a thermodynamic argument is given that explains the absence of coherent downdrafts descending from cloud top.
Absence of Evidence for Enhanced Benefit of Antibiotic Therapy on Recurrent Acute Rhinosinusitis Episodes: A Systematic Review of the Evidence Base
Authors: Kaper Nina M. , Breukel Laura , Venekamp Roderick P. , Grolman Wilko , van der Heijden Geert J. M. G. 
Published: September 2013

ObjectiveTo systematically review the evidence base on the effectiveness of short‐course antibiotic therapy in adult patients with a recurrent episode of acute rhinosinusitis as part of a disease pattern on severity and duration of symptoms and recurrences.Data SourcesPubMed, EMBASE, and the Cochrane Library.Review MethodsA comprehensive search was performed up to March 21, 2013. Articles reporting studies on the effects of short‐course antibiotic therapy compared with placebo in patients with recurrent acute rhinosinusitis were included. For included articles, the design of reported studies was assessed for directness of evidence and risk of bias.ResultsIn total, 3473 unique publications were retrieved, of which 30 were considered eligible based on title and abstract screening. In addition, 8 eligible articles were retrieved using cross‐reference checking. Based on full‐text evaluation, none of the retrieved 38 articles satisfied our predefined selection criteria. They did not compare antibiotic treatment with placebo, excluded patients with recurrent acute rhinosinusitis, or did not report findings for a subgroup of patients with recurrent acute rhinosinusitis.Conclusion and RecommendationTo date, there is no evidence available on differences in effect of antibiotic therapy in primary or sporadic and recurrent episodes of acute rhinosinusitis. As such, decisions for or against initial antibiotic therapy in patients with recurring episodes of acute rhinosinusitis should be based on the same criteria used in managing primary or sporadic episodes of uncomplicated acute rhinosinusitis.
Comparison of Sagittal Subluxation in Two Different Three-Component Total Ankle Replacement Systems
Authors: Lee Kyung Tai , Jegal Hyuk , Park Young Uk , Kim Jun Beom , Lee Young Koo , Yeo Eui Dong , Yang Seong Seok , Yoon Su-ah 
Published: September 2013

Background: Malalignment following total ankle arthroplasty (TAA) has been reported in 4% to 45% of patients. However, all reports to date have been related to coronal deformity. This study compared sagittal malalignment between the Mobility and Hintegra total ankle systems and assessed the positional stability of the implant components over time. Methods: The study included 50 cases each of total ankle replacement arthroplasty with the Hintegra and Mobility total ankle systems performed between May 2008 and June 2010. The Mobility group included 24 men and 25 women, and the mean age was 60.3 years (range, 50.7-70.0 years). The Hintegra group included 25 men and 25 women, and the mean age was 59.8 years (range, 50.8-68.7 years). The 2 groups did not differ in terms of gender ( P = .76) or age ( P = .77). Three independent observers with different levels of training evaluated the radiographs and performed the measurements independently. Each observer evaluated the radiographs twice at a 6-week interval to determine the intraobserver reliability, and the anteroposterior offset ratio was evaluated. Results: The anteroposterior offset ratio intra- and interobserver reliabilities all showed good or excellent levels of agreement in the Hintegra total ankle system and the Mobility total ankle system. With respect to the stability of sagittal translation of the talus, the Mobility system (0.08 ± 0.07 immediately, 0.0 ± 0.07 at 6 weeks postoperatively, and 0.01 ± 0.07 at 1 year postoperatively) was better than the Hintegra system (0.20 ± 0.08 immediately, 0.18 ± 0.11 at 6 weeks postoperatively, and 0.15 ± 0.10 at 1 year postoperatively) ( P < .0001). Conclusions: The Mobility system had less sagittal malalignment of the talus than the Hintegra system. Consequently, when treating ankles in patients with osteoarthritis using the Hintegra system, one must pay careful attention to sagittal malalignment during surgery. Level of Evidence: Level III, retrospective comparative series.
von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy
Authors: Lillicrap David 
Published: September 2013

Abstractvon Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative variants of VWF are now well characterized, with most mutations representing missense substitutions influencing VWF multimer structure and interactions with platelet GPIbα and collagen and with factor VIII. The molecular pathology of type 3 VWD has been similarly well characterized, with an array of different mutation types producing either a null phenotype or the production of VWF that is not secreted. In contrast, the pathogenetic mechanisms responsible for type 1 VWD remain only partially resolved. In the hemostasis laboratory, the measurement of VWF:Ag and VWF:RCo are key components in the diagnostic algorithm for VWD, although the introduction of direct GPIbα-binding assays may become the functional assay of choice. Molecular genetic testing can provide additional benefit, but its utility is currently limited to type 2 and 3 VWD. The treatment of bleeding in VWD involves the use of desmopressin and plasma-derived VWF concentrates and a variety of adjunctive agents. Finally, a new recombinant VWF concentrate has just completed clinical trial evaluation and has demonstrated excellent hemostatic efficacy and safety.
Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI
Authors: Copelan Edward A. , Hamilton Betty K. , Avalos Belinda , Ahn Kwang Woo , Bolwell Brian J. , Zhu Xiaochun , Aljurf Mahmoud , van Besien Koen , Bredeson Christopher , Cahn Jean-Yves , Costa Luciano J. , de Lima Marcos , Gale Robert Peter , Hale Gregory A. , Halter Joerg , Hamadani Mehdi , Inamoto Yoshihiro , Kamble Rammurti T. , Litzow Mark R. , Loren Alison W. , Marks David I. , Olavarria Eduardo , Roy Vivek , Sabloff Mitchell , Savani Bipin N. , Seftel Matthew , Schouten Harry C. , Ustun Celalettin , Waller Edmund K. , Weisdorf Daniel J. , Wirk Baldeep , Horowitz Mary M. , Arora Mukta , Szer Jeff , Cortes Jorge , Kalaycio Matt E. , Maziarz Richard T. , Saber Wael 
Published: September 2013

Key Points
In combination with cyclophosphamide, intravenous busulfan is associated with better leukemia-free and overall survival in AML than TBI.