bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Vaccination in the First Trimester and Major Structural Birth Defects Among Live Births
Authors: Kharbanda Elyse O. , DeSilva Malini B. , Lipkind Heather S. , Romitti Paul A. , Zhu Jingyi , Vesco Kimberly K. , Boyce Thomas G. , Daley Matthew F. , Fuller Candace C. , Getahun Darios , Jackson Lisa A. , Williams Joshua T. B. , Zerbo Ousseny , Weintraub Eric S. , Vazquez-Benitez Gabriela 
Published: July 2024

ImportanceCOVID-19 vaccination is recommended throughout pregnancy to prevent pregnancy complications and adverse birth outcomes associated with COVID-19 disease. To date, data on birth defects after first-trimester vaccination are limited.ObjectiveTo evaluate the associated risks for selected major structural birth defects among live-born infants after first-trimester receipt of a messenger RNA (mRNA) COVID-19 vaccine.Design, Setting, and ParticipantsThis was a retrospective cohort study of singleton pregnancies with estimated last menstrual period (LMP) between September 13, 2020, and April 3, 2021, and ending in live birth from March 5, 2021, to January 25, 2022. Included were data from 8 health systems in California, Oregon, Washington, Colorado, Minnesota, and Wisconsin in the Vaccine Safety Datalink.ExposuresReceipt of 1 or 2 mRNA COVID-19 vaccine doses in the first trimester, as part of the primary series.Main Outcomes and MeasuresSelected major structural birth defects among live-born infants, identified from electronic health data using validated algorithms, with neural tube defects confirmed via medical record review.ResultsAmong 42 156 eligible pregnancies (mean [SD] maternal age, 30.9 [5.0] years) 7632 (18.1%) received an mRNA COVID-19 vaccine in the first trimester. Of 34 524 pregnancies without a first-trimester COVID-19 vaccination, 2045 (5.9%) were vaccinated before pregnancy, 13 494 (39.1%) during the second or third trimester, and 18 985 (55.0%) were unvaccinated before or during pregnancy. Compared with pregnant people unvaccinated in the first trimester, those vaccinated in the first trimester were older (mean [SD] age, 32.3 [4.5] years vs 30.6 [5.1] years) and differed by LMP date. After applying stabilized inverse probability weighting, differences in baseline characteristics between vaccinated and unvaccinated pregnant persons in the first trimester were negligible (standardized mean difference &amp;lt;0.20). Selected major structural birth defects occurred in 113 infants (1.48%) after first-trimester mRNA COVID-19 vaccination and in 488 infants (1.41%) without first-trimester vaccine exposure; the adjusted prevalence ratio was 1.02 (95% CI, 0.78-1.33). In secondary analyses, with major structural birth defect outcomes grouped by organ system, no significant differences between infants vaccinated or unvaccinated in the first trimester were identified.Conclusions and RelevanceIn this multisite cohort study, among live-born infants, first-trimester mRNA COVID-19 vaccine exposure was not associated with an increased risk for selected major structural birth defects.
Homologous Tumor Targeting Molybdenum‐Doped Prussian Blue for Enhancing Immunotherapy via PTT/CDT and Remodeled Tumor Immune Microenvironment
Authors: Ma Shuaining , Li Dan , Jia Xiuna , Xu Weiguo , Ding Guanyu , He Juyang , Wang Jin 
Published: July 2024

AbstractImmunotherapy offers a promising avenue for reducing tumor metastasis and recurrence but faces challenges from the tumor immunosuppressive microenvironment (TIME) and restricted antigen presentation. To address these challenges, this study have developed an innovative approach utilizing molybdenum (Mo)‐doped Prussian blue nanoparticles coated with a cancer cell membrane (CCM), referred to as PMo@CCM. This novel nanoplatform excels in performing photothermal therapy (PTT), while the Mo and Fe components effectively deplete glutathione (GSH) and generate reactive oxygen species (ROS), thereby significantly enhancing chemodynamic therapy (CDT) and remodeling the TIME. The synergistic PTT/CDT approach not only induces tumor immunogenic cell death (ICD) but also facilitates antigen presentation. The CCM coating further supplies antigens and prompts dendritic cell (DC) maturation. This comprehensive strategy markedly enhances the effectiveness of immunotherapy, as evidenced by a significant increase in T cell activation. Moreover, the use of programmed cell death protein 1 antibodies (anti PD‐1) effectively blocks the PD‐1 immune checkpoint pathway. RNA sequencing analysis has identified genes associated with the observed substantial reduction in tumor growth. In conclusion, the PMo@CCM nanoplatform enables homologously targeted tumor synergistic therapy, guided by photothermal and magnetic resonance imaging (PTI&MRI), significantly impeding the progression of both primary and metastatic tumors.
Hermetic, Hybrid Multilayer, Sub‐5µm‐Thick Encapsulations Prepared with Vapor‐Phase Infiltration of Metal Oxides in Conformal Polymers for Flexible Bioelectronics
Authors: Mariello Massimo , von Allmen Marion , Wu Kangling , Van Gompel Matthias , Lacour Stéphanie P. , Leterrier Yves 
Published: July 2024

AbstractReliable long‐term function is crucial for flexible and soft bioelectronics. Mechanical defects and permeation of water molecules across the various device layers are the prime drivers of failure, and particularly in applications requiring continuous contact with biofluids (i.e. for implantable applications). To address demanding needs of miniaturization, mechanical compliance and water impermeability, ultra‐thin high‐barrier encapsulations are a promising way to improve device reliability. In this work, the encapsulation properties of vapour phase infiltration (VPI) of inorganic Al2O3 layers deposited by atomic layer deposition (ALD), as bilayers with TiO2, onto polyimide and parylene C organic substrates are investigated. The layers are grown in a single reactor and the infiltration is performed in a single process, with a resulting nanometric infiltration depth. Mechanical integrity and hermeticity are characterized through tensile fragmentation tests and accelerated aging tests. Flexible Magnesium sensors monitor water vapor permeability in situ. A remarkable improvement in the crack onset strain (∽2.56 times), interfacial shear strength (∽2.1 times), water vapour transmission rate (∽5.2 times) and lifetime performance (∽7.1 times) is achieved, compared to the non‐infiltrated ALD coatings. Pluri‐infiltrated multilayers are proposed as alternatives to conventional coatings. This work is envisioned to accelerate research progress on hermetic packaging of flexible bioelectronics.
Creation, Control, and Modeling of NV Centers in Nanodiamonds
Authors: Aprà Pietro , Amine Nour Hanne , Britel Adam , Sturari Sofia , Varzi Veronica , Ziino Matteo , Mino Lorenzo , Olivero Paolo , Picollo Federico 
Published: July 2024

AbstractSensing based on Nitrogen‐Vacancy (NV) centers in nanodiamonds (NDs) represents a potentially groundbreaking technology with broad applications. Nevertheless, the optimization of their quantum‐optical properties is still a challenging issue. The present work aims at enhancing and controlling NV centers optical properties in NDs by combining their surface chemistry tuning and proton beam irradiation. Systematic thermal oxidations are carried out to study the evolution of surface chemical groups (IR spectroscopy), as well as their influence on optical properties (photoluminescence spectroscopy, PL decay measurements). Proton irradiation is performed by exploring a wide range of fluences (1014 – 1017 cm−2) in order to precisely control the amount of NV centers, thus defining the conditions that maximize their creation and emission intensity. In addition, NV centers charge state control is achieved by assessing NV−/NV0 ratio upon different surface termination tuning and NV centers amount. Finally, a novel predictive mathematical model is developed, allowing for the evaluation of the efficiencies of the formation of both NV− and NV0. Although the model is tested in the specific case study with proton irradiated NDs, it offers a broad applicability, thus representing a key landmark in the prediction of the outcome of ion‐beam‐based color centers generation in diamond.
Insight Understanding of External Pressure on Lithium Plating in Commercial Lithium‐Ion Batteries
Authors: Yu Hanqing , Wang Li , Zhang Zhiguo , Li Yiding , Yang Shichun , He Xiangming 
Published: July 2024

AbstractLithium‐ion batteries (LIBs), as efficient electrochemical energy storage devices, have been successfully commercialized. Lithium plating at anodes has been attracting increasing attention as batteries advance toward high energy density and large size, given its pivotal role in affecting the lifespan, safety, and fast‐charging performance of LIBs. Lithium plating mostly happens during fast charging or charging at low temperatures. However, external pressure is often overlooked as an essential factor that influences lithium plating in LIBs. This review analyzes and discusses the influence of external pressure on performance for commercial LIBs, with a particular focus on lithium plating. Recent advances in this topic, including experimental results and mechanism analyses, are reviewed. Lithium plating is explored by examining the influence of pressure on the internal morphology and electrochemical behavior of batteries. It is emphasized that external pressure affects performance through ion transport, electron transport, and their heterogeneities, thereby increasing the risk of lithium plating in batteries. Subsequently, the rationale for external pressure mitigating lithium plating is elucidated from the perspective of the morphology optimization inside LIBs. Overall, this review provides valuable insights into the role of external pressure on lithium plating in commercial LIBs, practically guiding their rational design and development.
3D Bionic Water Harvesting System for Efficient Fog Capturing and Transporting
Authors: Zhang Huayang , Chen Guopeng , Xie Shangzhen , Fu Ye , Tian Guangyi , Zheng Jianyong , Wang Biao , Guo Zhiguang 
Published: July 2024

AbstractFog harvest has emerged as a direct and efficient water harvesting technology to relieve the intense pressure of freshwater scarcity worldwide. With the vagaries of climate and increasing amount of energy consumption, high‐efficiency fog harvest devices focus on the fast water droplet capture and transportation are highly desired. In this study, a novel harp structure is developed using cross‐twisted copper filaments arranged in a spatial triangular pattern to enhance water droplet capture and transportation. Inspired by the natural differences in Laplace pressure observed in cactus and spider silks, this design accelerates the movement of water bridges. Besides, drawing on the fruit waxes on the surface of hogweed and blueberries, a paraffin wax coating is applied on the copper sheet frame to create a solid slip frame, improving the synergy between filament capture and frame transportation. The monolithic fog collector (MFC) thus achieves a significant increase in fog harvest efficiency and demonstrates excellent durability. Integration of the MFCs into a 3D high‐efficiency fog harvest system results in a harvest rate of 0.5027 g cm−2 min−1, showing promise for practical applications due to its durability, simplicity, and environmental friendliness.
Self‐Floating Polymer Microreactor for High‐Efficiency Synergistic CO2 Photoreduction and Antibiotic Degradation in One Photoredox Cycle
Authors: Wang Mengmeng , Zhang Yingxue , Dong Shihong , Li Najun , Xu Qingfeng , Li Hua , Lu Jianmei , Chen Dongyun 
Published: July 2024

AbstractConstructing a novel photocatalyst to realize both pollutant oxidation and evolved CO2 reduction in one photoredox cycle can significantly reframe the role of pollutant management. Here, self‐floating poly(bismaleimide‐co‐divinylbenzene) porous microspheres (PBMs) are filled with ZnSnO3 quantum dots (ZSO QDs) to construct a polymer composite microreactor with an S‐scheme heterojunction (ZSO QDs/AP‐PBMs). This microreactor realizes efficient catalytic oxidation and degradation of antibiotic pollutants under light, and the CO2 generated in this process is reduced to high value‐added CO, allowing for the direct conversion of pollutants to a resource in one photoredox cycle. The high specific surface area of the PBMs enables the rapid and efficient adsorption of levofloxacin (LVX), and the self‐floating porous design effectively solves the problem of CO2 adsorption and mass transfer in the gas–liquid–solid three‐phase system, while the S‐scheme heterostructure enhances charge carrier separation. As a result, ZSO QDs/AP‐PBMs achieves complete degradation of LVX in one redox cycle with 100% selectivity to produce 100.3 µmol g−1 CO, and further draw a conclusion that fluoroquinones antibiotics as excellent electron donors can significantly enhance co‐catalytic effect with CO2, which is not previously reported. Theoretical calculations and characterization experiments provide information on S‐scheme heterojunction transfer mechanism and possible degradation pathways, allowing for the rational design of photoredox bifunctional catalysts.
Wet Tissue Interfacial Water Triggers Ultrafast In Situ Gelation of Sprayable Dry Powder for Postoperative Anti‐Adhesion
Authors: Wen Chaoyao , Gong Yihang , Chen Haoyan , Tian Yu , Yu Hui , Xin Xudan , Wang Le , Xiang Chuyang , Chen Yisheng , Xiao Tianhua , Ning Chengyun , Yang Xuebin , Zhou Lei , Tan Guoxin 
Published: July 2024

AbstractPostoperative adhesions complicate the majority of surgical procedures, imposing an excess medical burden. The segregation of injured tissue from healthy tissue is considered the optimal therapeutic strategy. However, achieving hemostasis while preventing adhesions in the immediate postoperative setting continues to pose a significant challenge. This paper presents the in situ formation of an asymmetrically adhesive hydrogel barrier via a sprayable dry powder (SDP) that enables interfacial water‐induced, ultra‐rapid gelation. Owing to SDP hydrophilicity and the interstitial spaces between particles, it can rapidly and efficiently absorb interfacial water, thereby facilitating smooth cross‐linking between material functional groups and tissue functional groups. In addition, SDP becomes less adhesive after gelation as a layer of interfacial water forms on the surface of the SDP hydrogel, enhancing its anti‐adhesion properties. Animal experiment outcomes demonstrate that SDP exhibits significant asymmetric adhesive properties before and after gelation, successfully preventing postoperative adhesions. As a result, SDP heralds a novel approach to the development of adhesives that can simultaneously mitigate adhesions and promptly arrest bleeding.
UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier
Authors: Ran Linyu , Chen Miao , Ye Jihui , Zhang Song , Luo Zhibing , Bai Tengfei , Qian Chenchen , Zhou Quan , Shan Mengtian , Chu Yong , Herrmann Joerg , Li Qiang , Wang Feilong 
Published: July 2024

AbstractTargeting NLRP3 inflammasome has been recognized as a promising therapeutic strategy for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of mitochondrial pyruvate carrier (MPC), is previously found to inhibit macrophage inflammatory responses independent of MPC expression. However, the mechanisms by which UK5099 inhibit inflammatory responses remain unclear. Here, it is shown that UK5099 is a potent inhibitor of the NLRP3 inflammasome in both mouse and human primary macrophages. UK5099 selectively suppresses the activation of the NLRP3 but not the NLRC4 or AIM2 inflammasomes. Of note, UK5099 retains activities on NLRP3 in macrophages devoid of MPC expression, indicating this inhibitory effect is MPC‐independent. Mechanistically, UK5099 abrogates mitochondria‐NLRP3 interaction and in turn inhibits the assembly of the NLRP3 inflammasome. Further, a single dose of UK5099 persistently reduces IL‐1β production in an endotoxemia mouse model. Importantly, structure modification reveals that the inhibitory activities of UK5099 on NLRP3 are unrelated to the existence of the activated double bond within the UK5099 molecule. Thus, this study uncovers a previously unknown molecular target for UK5099, which not only offers a new candidate for the treatment of NLRP3‐driven diseases but also confounds its use as an MPC inhibitor in immunometabolism studies.
Genetically Engineered Membrane‐Coated Nanoparticles for Enhanced Prostate‐Specific Membrane Antigen Targeting and Ferroptosis Treatment of Castration‐Resistant Prostate Cancer
Authors: Li Yu , Li Hongji , Zhang Keying , Xu Chao , Wang Jingwei , Li Zeyu , Zhou Yike , Liu Shaojie , Zhao Xiaolong , Li Zhengxuan , Yang Fa , Hu Wei , Jing Yuming , Wu Peng , Zhang Jingliang , Shi Changhong , Zhang Rui , Jiang Wenkai , Xing Nianzeng , Wen Weihong , Han Donghui , Qin Weijun 
Published: July 2024

AbstractConventional androgen deprivation therapy (ADT) targets the androgen receptor (AR) inhibiting prostate cancer (PCa) progression; however, it can eventually lead to recurrence as castration‐resistant PCa (CRPC), which has high mortality rates and lacks effective treatment modalities. The study confirms the presence of high glutathione peroxidase 4 (GPX4) expression, a key regulator of ferroptosis (i.e., iron‐dependent program cell death) in CRPC cells. Therefore, inducing ferroptosis in CRPC cells might be an effective therapeutic modality for CRPC. However, nonspecific uptake of ferroptosis inducers can result in undesirable cytotoxicity in major organs. Thus, to precisely induce ferroptosis in CRPC cells, a genetic engineering strategy is proposed to embed a prostate‐specific membrane antigen (PSMA)‐targeting antibody fragment (gy1) in the macrophage membrane, which is then coated onto mesoporous polydopamine (MPDA) nanoparticles to produce a biomimetic nanoplatform. The results indicate that the membrane‐coated nanoparticles (MNPs) exhibit high specificity and affinity toward CRPC cells. On further encapsulation with the ferroptosis inducers RSL3 and iron ions, MPDA/Fe/RSL3@M‐gy1 demonstrates superior synergistic effects in highly targeted ferroptosis therapy eliciting significant therapeutic efficacy against CRPC tumor growth and bone metastasis without increased cytotoxicity. In conclusion, a new therapeutic strategy is reported for the PSMA‐specific, CRPC‐targeting platform for ferroptosis induction with increased efficacy and safety.
Branched‐Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel
Authors: Zhou Ze‐Yu , Wang Ji‐Ying , Li Zhi‐Xiao , Zheng Hong‐Li , Zhou Ya‐Nan , Huang Li‐Na , Wang Li‐Juan , Ding Xiao‐Wei , Sun Xin , Cai Ke , Zhao Rui , Shi Yan , Chen Alex F. , Pan Zhi‐Qiang , Cao Jing , Lin Fu‐Qing , Zhao Jian‐Yuan 
Published: July 2024

AbstractDiabetic neuropathic pain (DNP), one of the most common complications of diabetes, is characterized by bilateral symmetrical distal limb pain and substantial morbidity. To compare the differences is aimed at serum metabolite levels between 81 DNP and 73 T2DM patients without neuropathy and found that the levels of branched‐chain amino acids (BCAA) are significantly lower in DNP patients than in T2DM patients. In high‐fat diet/low‐dose streptozotocin (HFD/STZ)‐induced T2DM and leptin receptor‐deficient diabetic (db/db) mouse models, it is verified that BCAA deficiency aggravated, whereas BCAA supplementation alleviated DNP symptoms. Mechanistically, using a combination of RNA sequencing of mouse dorsal root ganglion (DRG) tissues and label‐free quantitative proteomic analysis of cultured cells, it is found that BCAA deficiency activated the expression of L‐type amino acid transporter 1 (LAT1) through ATF4, which is reversed by BCAA supplementation. Abnormally upregulated LAT1 reduced Kv1.2 localization to the cell membrane, and inhibited Kv1.2 channels, thereby increasing neuronal excitability and causing neuropathy. Furthermore, intraperitoneal injection of the LAT1 inhibitor, BCH, alleviated DNP symptoms in mice, confirming that BCAA‐deficiency‐induced LAT1 activation contributes to the onset of DNP. These findings provide fresh insights into the metabolic differences between DNP and T2DM, and the development of approaches for the management of DNP.
In‐Plane Overdamping and Out‐Plane Localized Vibration Contribute to Ultralow Lattice Thermal Conductivity of Zintl Phase KCdSb
Authors: Guo Kai , Zhang Juan , Yu Xiaotong , Jiang Yuanxin , Li Yang , Zeng Yuqi , Lian Ruixiao , Yang Xinxin , Li Shuankui , Luo Jun , Li Wen , Zhang Hao 
Published: July 2024

AbstractZintl phases typically exhibit low lattice thermal conductivity, which are extensively investigated as promising thermoelectric candidates. While the significance of Zintl anionic frameworks in electronic transport properties is widely recognized, their roles in thermal transport properties have often been overlooked. This study delves into KCdSb as a representative case, where the [CdSb4/4]− tetrahedrons not only impact charge transfer but also phonon transport. The phonon velocity and mean free path, are heavily influenced by the bonding distance and strength of the Zintl anions Cd and Sb, considering the three acoustic branches arising from their vibrations. Furthermore, the weakly bound Zintl cation K exhibits localized vibration behaviors, resulting in strong coupling between the high‐lying acoustic branch and the low‐lying optical branch, further impeding phonon diffusion. The calculations reveal that grain boundaries also contribute to the low lattice thermal conductivity of KCdSb through medium‐frequency phonon scattering. These combined factors create a glass‐like thermal transport behavior, which is advantageous for improving the thermoelectric merit of zT. Notably, a maximum zT of 0.6 is achieved for K0.84Na0.16CdSb at 712 K. The study offers both intrinsic and extrinsic strategies for developing high‐efficiency thermoelectric Zintl materials with extremely low lattice thermal conductivity.
Materials Containing Single‐, Di‐, Tri‐, and Multi‐Metal Atoms Bonded to C, N, S, P, B, and O Species as Advanced Catalysts for Energy, Sensor, and Biomedical Applications
Authors: Tiwari Jitendra N. , Kumar Krishan , Safarkhani Moein , Umer Muhammad , Vilian A. T. Ezhil , Beloqui Ana , Bhaskaran Gokul , Huh Yun Suk , Han Young‐Kyu 
Published: July 2024

AbstractModifying the coordination or local environments of single‐, di‐, tri‐, and multi‐metal atom (SMA/DMA/TMA/MMA)‐based materials is one of the best strategies for increasing the catalytic activities, selectivity, and long‐term durability of these materials. Advanced sheet materials supported by metal atom‐based materials have become a critical topic in the fields of renewable energy conversion systems, storage devices, sensors, and biomedicine owing to the maximum atom utilization efficiency, precisely located metal centers, specific electron configurations, unique reactivity, and precise chemical tunability. Several sheet materials offer excellent support for metal atom‐based materials and are attractive for applications in energy, sensors, and medical research, such as in oxygen reduction, oxygen production, hydrogen generation, fuel production, selective chemical detection, and enzymatic reactions. The strong metal–metal and metal–carbon with metal–heteroatom (i.e., N, S, P, B, and O) bonds stabilize and optimize the electronic structures of the metal atoms due to strong interfacial interactions, yielding excellent catalytic activities. These materials provide excellent models for understanding the fundamental problems with multistep chemical reactions. This review summarizes the substrate structure‐activity relationship of metal atom‐based materials with different active sites based on experimental and theoretical data. Additionally, the new synthesis procedures, physicochemical characterizations, and energy and biomedical applications are discussed. Finally, the remaining challenges in developing efficient SMA/DMA/TMA/MMA‐based materials are presented.