bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequencing of Charcot–Marie–Tooth disease genes in a toxic polyneuropathy
Authors: Beutler Andreas S. , Kulkarni Amit A. , Kanwar Rahul , Klein Christopher J. , Therneau Terry M. , Qin Rui , Banck Michaela S. , Boora Ganesh K. , Ruddy Kathryn J. , Wu Yanhong , Smalley Regenia L. , Cunningham Julie M. , Le‐Lindqwister Nguyet Anh , Beyerlein Peter , Schroth Gary P. , Windebank Anthony J. , Züchner Stephan , Loprinzi Charles L. 
Published: August 2014

ObjectiveMutations in Charcot–Marie–Tooth disease (CMT) genes are the cause of rare familial forms of polyneuropathy. Whether allelic variability in CMT genes is also associated with common forms of polyneuropathy—considered “acquired” in medical parlance—is unknown. Chemotherapy‐induced peripheral neuropathy (CIPN) occurs commonly in cancer patients and is individually unpredictable. We used CIPN as a clinical model to investigate the association of non‐CMT polyneuropathy with CMT genes.MethodsA total of 269 neurologically asymptomatic cancer patients were enrolled in the clinical trial Alliance N08C1 to receive the neurotoxic drug paclitaxel, while undergoing prospective assessments for polyneuropathy. Forty‐nine CMT genes were analyzed by targeted massively parallel sequencing of genomic DNA from patient blood.ResultsA total of 119 (of 269) patients were identified from the 2 ends of the polyneuropathy phenotype distribution: patients that were most and least susceptible to paclitaxel polyneuropathy. The CMT gene PRX was found to be deleteriously mutated in patients who were susceptible to CIPN but not in controls (p = 8 × 10−3). Genetic variation in another CMT gene, ARHGEF10, was highly significantly associated with CIPN (p = 5 × 10−4). Three nonsynonymous recurrent single nucleotide variants contributed to the ARHGEF10 signal: rs9657362, rs2294039, and rs17683288. Of these, rs9657362 had the strongest effect (odds ratio = 4.8, p = 4 × 10−4).InterpretationThe results reveal an association of CMT gene allelic variability with susceptibility to CIPN. The findings raise the possibility that other acquired polyneuropathies may also be codetermined by genetic etiological factors, of which some may be related to genes already known to cause the phenotypically related Mendelian disorders of CMT. Ann Neurol 2014;76:727–737
Introduction of an Ionic Liquid into the Micropores of a Metal–Organic Framework and Its Anomalous Phase Behavior
Authors: Fujie Kazuyuki , Yamada Teppei , Ikeda Ryuichi , Kitagawa Hiroshi 
Published: August 2014

AbstractControlling the dynamics of ionic liquids (ILs) is a significant issue for widespread use. Metal–organic frameworks (MOFs) are ideal host materials for ILs because of their small micropores and tunable host–guest interactions. Herein, we demonstrate the first example of an IL incorporated within the micropores of a MOF. The system studied consisted of EMI‐TFSA (1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)amide) and ZIF‐8 (composed of Zn(MeIM)2; H(MeIM)=2‐methylimidazole) as the IL and MOF, respectively. Construction of the EMI‐TFSA in ZIF‐8 was confirmed by X‐ray powder diffraction, nitrogen gas adsorption, and infrared absorption spectroscopy. Differential scanning calorimetry and solid‐state NMR measurements showed that the EMI‐TFSA inside the micropores demonstrated no freezing transition down to 123 K, whereas bulk EMI‐TFSA froze at 231 K. Such anomalous phase behavior originates from the nanosize effect of the MOF on the IL. This result provides a novel strategy for stabilizing the liquid phase of the ILs down to a lower temperature region.
Experimental and Computational Studies on the Reactivity of a Terminal Thorium Imidometallocene towards Organic Azides and Diazoalkanes
Authors: Ren Wenshan , Zhou Enwei , Fang Bo , Hou Guohua , Zi Guofu , Fang De‐Cai , Walter Marc D. 
Published: August 2014

AbstractThe reaction of the base‐free terminal thorium imido complex [{η5‐1,2,4‐(Me3C)3C5H2}2ThN(p‐tolyl)] (1) with p‐azidotoluene yielded irreversibly the tetraazametallacyclopentene [{η5‐1,2,4‐(Me3C)3C5H2}2Th{N(p‐tolyl)NNN(p‐tolyl)}] (2), whereas the bridging imido complex [{[η5‐1,2,4‐(Me3C)3C5H2]Th(N3)2}2{μ‐N(p‐tolyl)}2][(n‐C4H9)4N]2 (3) was isolated from the reaction of 1 with [(n‐C4H9)4N]N3. Unexpectedly, upon the treatment of 1 with 9‐diazofluorene, the NN bond was cleaved, an N atom was transferred, and the η2‐diazenido iminato complex [{η5‐1,2,4‐(Me3C)3C5H2}2Th{η2‐[NN(p‐tolyl)]}{N(9‐C13H8)}] (4) was formed. In contrast, the reaction of 1 with Me3SiCHN2 gave the nitrilimido complex [{η5‐1,2,4‐(Me3C)3C5H2}2Th{NH(p‐tolyl)}{N2CSiMe3}] (5), which slowly converted into [{η5‐1,2,4‐(Me3C)3C5H2}{η5:κ‐N‐1,2‐(Me3C)2‐4‐CMe2(CH2NNCHSiMe3)C5H2}Th{NH(p‐tolyl)}] (6) by intramolecular CH bond activation. The experimental results are complemented by density functional theory (DFT) studies.
Unravelling the Correlation between the Aspect Ratio of Nanotubular Structures and Their Electrochemical Performance To Achieve High‐Rate and Long‐Life Lithium‐Ion Batteries
Authors: Tang Yuxin , Zhang Yanyan , Deng Jiyang , Qi Dianpeng , Leow Wan Ru , Wei Jiaqi , Yin Shengyan , Dong Zhili , Yazami Rachid , Chen Zhong , Chen Xiaodong 
Published: August 2014

AbstractThe fundamental understanding of the relationship between the nanostructure of an electrode and its electrochemical performance is crucial for achieving high‐performance lithium‐ion batteries (LIBs). In this work, the relationship between the nanotubular aspect ratio and electrochemical performance of LIBs is elucidated for the first time. The stirring hydrothermal method was used to control the aspect ratio of viscous titanate nanotubes, which were used to fabricate additive‐free TiO2‐based electrode materials. We found that the battery performance at high charging/discharging rates is dramatically boosted when the aspect ratio is increased, due to the optimization of electronic/ionic transport properties within the electrode materials. The proof‐of‐concept LIBs comprising nanotubes with an aspect ratio of 265 can retain more than 86 % of their initial capacity over 6000 cycles at a high rate of 30 C. Such devices with supercapacitor‐like rate performance and battery‐like capacity herald a new paradigm for energy storage systems.
Anion–π and Cation–π Interactions on the Same Surface
Authors: Fujisawa Kaori , Beuchat César , Humbert‐Droz Marie , Wilson Adam , Wesolowski Tomasz A. , Mareda Jiri , Sakai Naomi , Matile Stefan 
Published: August 2014

AbstractHerein, we address the question whether anion–π and cation–π interactions can take place simultaneously on the same aromatic surface. Covalently positioned carboxylate–guanidinium pairs on the surface of 4‐amino‐1,8‐naphthalimides are used as an example to explore push–pull chromophores as privileged platforms for such “ion pair–π” interactions. In antiparallel orientation with respect to the push–pull dipole, a bathochromic effect is observed. A red shift of 41 nm found in the least polar solvent is in good agreement with the 70 nm expected from theoretical calculations of ground and excited states. Decreasing shifts with solvent polarity, protonation, aggregation, and parallel carboxylate–guanidinium pairs imply that the intramolecular Stark effect from antiparallel ion pair–π interactions exceeds solvatochromic effects by far. Theoretical studies indicate that carboxylate–guanidinium pairs can also interact with the surfaces of π‐acidic naphthalenediimides and π‐basic pyrenes.
Palladium‐Catalyzed Asymmetric Decarboxylative Cycloaddition of Vinylethylene Carbonates with Michael Acceptors: Construction of Vicinal Quaternary Stereocenters
Authors: Khan Ajmal , Yang Lei , Xu Jing , Jin Long Yi , Zhang Yong Jian 
Published: August 2014

AbstractAn efficient method for the diastereo‐ and enantioselective construction of vicinal all‐carbon quaternary stereocenters through palladium‐catalyzed decarboxylative cycloaddition of vinylethylene carbonates with activated Michael acceptors was developed. By using a palladium complex generated in situ from [Pd2(dab)3]⋅CHCl3 and a phosphoramidite ligand as a catalyst under mild reaction conditions, the process provides multifunctionalized tetrahydrofurans bearing vicinal all‐carbon quaternary stereocenters in high yields with a high level of absolute and relative stereocontrol.
Toughening epoxy resin with blocked isocyanate containing soft chain
Authors: Lou Chunhua , Zhang Xiao , Wang Yuwei , Chen Zhaohui , Li Hongshuang 
Published: August 2014

ABSTRACTA series of imidazole (MI) blocked 2,4‐toluene diisocyanate (TDI) with polyethylene glycol (PEG‐400) as soft segment (PEG‐MI‐b‐TDI) were synthesized for toughening and curing the bisphenol A type epoxy resin (E‐44). Fourier transform infrared (FTIR) spectrum indicates that the NCO groups of the isocyanate molecule are blocked with MI. For curing epoxy systems, elimination of epoxy group and the formation of urethane bonds were studied by FTIR spectroscopy. The results of mechanical property were shown that the tensile shear and impact strengths of neat MI and MI‐b‐TDI cured E‐44 are lower than those of PEG‐MI‐b‐TDI cured E‐44. Based on the scanning electron microscope studies, microstructure evolutions of the E‐44 cured by different curing agents were imaged. The mechanical, thermal, and dynamic mechanical properties were measured by universal testing machine, differential scanning calorimeter and dynamic mechanical analyzer (DMA). The toughness of E‐44 cured by PEG‐MI‐b‐TDI was effectively improved without sacrificing the tensile shear strength. Based on the DMA studies, the long soft chain of PEG brought in a noticeable lowering in the glass transition temperature (Tg). The glass transition temperature is near 165°C for the neat MI cured E‐44, which is higher than the Tgs of the other curing agents cured epoxy. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41345.
Interfacial damage on fatigue‐loaded textile–rubber composites
Authors: Valantin Chloé , Lacroix Florian , Deffarges Marie‐Pierre , Morcel Julie , Aït Hocine Nourredine 
Published: August 2014

ABSTRACTTo reach admissible lifetime expectancy, unidirectional textile–rubber composites must show a strong interface. Usually, it is achieved by coating the textile with Resorcinol–Formaldehyde–Latex (RFL). To evaluate fatigue impact on interfacial properties, composites with or without RFL are tested at different numbers of loading cycles and characterized through peel tests, dynamic mechanical analysis (DMA), scanning electron microscopy and energy‐dispersive X‐rays, and nanoindentation. For composites with RFL, the results indicate two main mechanisms for damaging: propagation of pre‐existing fibrillar microcracks at the rubber/RFL interface completed by adhesive debondings at the RFL/textile interface. At first, the propagation of fibrillar microcracks is correlated with decrease of global composite peeling resistance and contribution of interphase to DMA damping. Then, RFL/textile debondings become critical. They are highlighted with a change of peeling failure surface and could be explained by RFL hardening, highlighted by nanoindentation. This questions the choice for RFL as a sustainable adhesive for composites under fatigue loading. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41346.
Deoxygenation performance of polydimethylsiloxane mixed‐matrix membranes for dissolved oxygen removal from water
Authors: Li Ting , Yu Ping , Luo Yunbai 
Published: August 2014

ABSTRACTThe removal of dissolved oxygen (DO) from water is an essential and important step in many industrial applications. The membrane technique offers much potential superiority over conventional physical and chemical processes. The development of a high‐performance membrane is the core of the membrane separation technique. In this study, a crosslinked matrix composed of a polydimethylsiloxane (PDMS) membrane with incorporated silica networks by the sol–gel method was manufactured. The application of the membrane method for the removal of DO from water on the laboratory scale was studied. The membrane properties and morphological structure were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, crosslinking density, and mechanical measurements. The PDMS hybrid membranes on the deoxygenation experiment by a vacuum degassing process were investigated. The results show that the crosslinked PDMS hybrid membranes effectively improved the oxygen‐removal efficiency with increasing tetraethoxysilane (TEOS) content, and the best performance was obtained when the weight ratio of PDMS–TEOS concentrations was 10:5. The optimal conditions for the deoxygenation performance were also investigated, and the results indicate that the degassing performances were related to the operating temperature, vacuum level, and feed flow rate. The PDMS nonporous composite membranes showed superior performances and have good potential for applications in industry for the removal of DO from water. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41350.
Association Between Experimental Pain Biomarkers and Serologic Markers in Patients With Different Degrees of Painful Knee Osteoarthritis
Authors: Arendt‐Nielsen Lars , Eskehave Thomas N. , Egsgaard Line L. , Petersen Kristian K. , Graven‐Nielsen Thomas , Hoeck Hans C. , Simonsen Ole , Siebuhr Anne S. , Karsdal Morten , Bay‐Jensen Anne C. 
Published: August 2014

ObjectiveTo assess the association between pain mechanisms (sensitization) and biochemical markers for cartilage, bone, and inflammation in patients with knee pain.MethodsThe study group comprised 281 patients with different degrees of knee pain intensity and radiographic findings (using the Kellgren/Lawrence [K/L] scale). The following structurally related serologic biomarkers were measured in serum: high‐sensitivity C‐reactive protein (hsCRP), matrix metalloproteinase (MMP)–mediated breakdown of CRP (CRPM), MMP‐mediated degradation of type I collagen (C1M), C2M, and C3M. Pressure–pain thresholds (PPT) (peripheral and spreading sensitization), temporal summation of pain, and conditioning pain modulation (CPM) (with the latter 2 biomarkers representing generalized sensitization) were assessed. For each pain parameter, the patients were categorized as most sensitized or least sensitized.ResultsCorrelations were observed between the pain biomarkers PPT, temporal summation, and CPM and maximal pain intensity during the last 24 hours. Significant associations between most of the serologic biomarkers were observed. A high CRPM level was associated with centralized sensitization (temporal summation and CPM). None of the serologic markers correlated with the intensity or duration of knee pain, and only hsCRP correlated with the K/L grade. The most‐sensitized group contained more women than men, and the least‐sensitized group contained more men than women.ConclusionA platform of mechanistic pain biomarkers in combination with structure‐related serologic biomarkers provides new possibilities for understanding how osteoarthritis‐related structural features may be associated with pain and pain sensitization. This study showed significant correlations between central pain sensitization and CRPM as a possible measure for chronic inflammation. Future pain association studies should include biomarkers representing the local joint environment more specifically.
Oligopeptide‐Assisted Self‐Assembly of Oligothiophenes: Co‐Assembly and Chirality Transfer
Authors: Guo Zongxia , Gong Ruiying , Mu Youbing , Wang Xiao , Wan Xiaobo 
Published: August 2014

AbstractThe biomolecule‐assisted self‐assembly of semiconductive molecules has been developed recently for the formation of potential bio‐based functional materials. Oligopeptide‐assisted self‐assembly of oligothiophene through weak intermolecular interactions was investigated; specifically the self‐assembly and chirality‐transfer behavior of achiral oligothiophenes in the presence of an oligopeptide with a strong tendency to form β‐sheets. Two kinds of oligothiophenes without (QT) or with (QTDA) carboxylic groups were selected to explore the effect of the end functional group on self‐assembly and chirality transfer. In both cases, organogels were formed. However, the assembly behavior of QT was quite different from that of QTDA. It was found that QT formed an organogel with the oligopeptide and co‐assembled into chiral nanostructures. Conversely, although QTDA also formed a gel with the oligopeptide, it has a strong tendency to self‐assemble independently. However, during the formation of the xerogel, the chirality of the oligopeptide can also be transferred to the QTDA assemblies. Different assembly models were proposed to explain the assembly behavior.
Converting Ag2SCdS and Ag2SZnS into AgCdS and AgZnS Nanoheterostructures by Selective Extraction of Sulfur
Authors: Zhou Jiangcong , Huang Feng , Xu Ju , Wang Yuansheng 
Published: August 2014

AbstractA mild three‐step solution strategy is developed to prepare AgMS (M=Zn, Cd) nanoheterostructures composed of MS nanorods with silver tips. First, Ag2SMS heterostructures are synthesized by following a solution–liquid–solid mechanism with Ag2S nanoparticles as catalysts, then the Ag2S sections of the heterostructures are converted into silver nanoparticles by selective extraction of sulfur. Notably, for the prepared AgCdS heterostructures, the localized surface plasmon resonance of silver remarkably intensifies the photoluminescence of CdS by enhancing the excitation light absorption, which is beneficial for potential applications of CdS nanoparticles in the fields of biolabeling, light‐emitting diodes, and so forth. The strategy reported herein would be useful for designing and fabricating other metal–semiconductor hybrid nanostructures with desirable performances.
Core–Shell α‐Fe2O3@α‐MoO3 Nanorods as Lithium‐Ion Battery Anodes with Extremely High Capacity and Cyclability
Authors: Wang Qiang , Wang Qi , Zhang De‐An , Sun Jing , Xing Li‐Li , Xue Xin‐Yu 
Published: August 2014

Abstractα‐Fe2O3 nanoparticles are uniformly coated on the surface of α‐MoO3 nanorods through a two‐step hydrothermal synthesis method. As the anode of a lithium‐ion battery, α‐Fe2O3@α‐MoO3 core–shell nanorods exhibit extremely high lithium‐storage performance. At a rate of 0.1 C (10 h per half cycle), the reversible capacity of α‐Fe2O3@α‐MoO3 core–shell nanorods is 1481 mA h g−1 and a value of 1281 mA h g−1 is retained after 50 cycles, which is much higher than that retained by bare α‐MoO3 and α‐Fe2O3 and higher than traditional theoretical results. Such a good performance can be attributed to the synergistic effect between α‐Fe2O3 and α‐MoO3, the small size effect, one‐dimensional nanostructures, short paths for lithium diffusion, and interface spaces. Our results reveal that core–shell nanocomposites have potential applications as high‐performance lithium‐ion batteries.
Synthesis of Di‐ and Trixanthones that Display High Stability and a Visual Fluorescence Response to Strong Acid
Authors: Wang Baolin , Shao Jiafeng , Xu Taoshan , Chen Lichuan , Zhao Jinlian , Shao Yongliang , Zhang Hao‐Li , Shao Xiangfeng 
Published: August 2014

AbstractThree dixanthones (1–3) and an unprecedented C3h‐symmetric trixanthone (4) were synthesized through a three‐step approach in overall yields above 63 %. These compounds possessed a planar π‐conjugated system and formed tight face‐to‐face columnar stacks, as confirmed by single‐crystal structural analysis. In comparison with xanthone, the fluorescence emissions of compounds 1–4 showed significant red‐shifts, with improved quantum yields. Moreover, the fluorescence emissions of compounds 1–4 could be modulated in a strongly acidic environment without decomposition, which led to a further red‐shift of the emissions, as well as enhancement of the emission intensities. These compounds have potential applications as optoelectronic materials and/or chemosensors.
Structures of Chlorinated Fullerenes, IPR C96Cl20 and Non‐classical C94Cl28 and C92Cl32: Evidence of the Existence of Three New Isomers of C96
Authors: Yang Shangfeng , Wei Tao , Wang Song , Ioffe Ilya N. , Kemnitz Erhard , Troyanov Sergey I. 
Published: August 2014

AbstractChlorination of various HPLC fractions of C96 with a mixture of VCl4 and SbCl5 at 340–360 °C and single‐crystal X‐ray diffraction study of the products led to the identification of three new IPR isomers of C96. The C96(175) isomer forms a stable chloride, C96(175)Cl20, while chlorides of two other new isomers, C96(114) and C96(80), undergo cage shrinkage yielding C94(NC1)Cl28 and C96(NC2)Cl32 with non‐classical (NC) cages. These two NC chlorides contain, respectively, one and two heptagons flanked by pairs of fused pentagons and are stabilized by chlorine attachment to the emerging pentagon–pentagon junctions. Thus, the number of the experimentally confirmed C96 isomers has reached nine, which corroborates the empirical rule that the C6n fullerenes exhibit particularly rich isomerism.
Metabolic engineering of 3‐hydroxypropionic acid biosynthesis in Escherichia coli
Authors: Chu Hun Su , Kim Young Soo , Lee Chan Mu , Lee Ju Hee , Jung Won Seok , Ahn Jin‐Ho , Song Seung Hoon , Choi In Suk , Cho Kwang Myung 
Published: August 2014

ABSTRACT3‐Hydroxypropionic acid (3‐HP) can be produced in microorganisms as a versatile platform chemical. However, owing to the toxicity of the intermediate product 3‐hydroxypropionaldehyde (3‐HPA), the minimization of 3‐HPA accumulation is critical for enhancing the productivity of 3‐HP. In this study, we identified a novel aldehyde dehydrogenase, GabD4 from Cupriavidus necator, and found that it possessed the highest enzyme activity toward 3‐HPA reported to date. To augment the activity of GabD4, several variants were obtained by site‐directed and saturation mutagenesis based on homology modeling. Escherichia coli transformed with the mutant GabD4_E209Q/E269Q showed the highest enzyme activity, which was 1.4‐fold higher than that of wild type GabD4, and produced up to 71.9 g L−1 of 3‐HP with a productivity of 1.8 g L−1 h−1. To the best of our knowledge, these are the highest 3‐HP titer and productivity values among those reported in the literature. Additionally, our study demonstrates that GabD4 can be a key enzyme for the development of industrial 3‐HP‐producing microbial strains, and provides further insight into the mechanism of aldehyde dehydrogenase activity. Biotechnol. Bioeng. 2015;112: 356–364. © 2014 Wiley Periodicals, Inc.