bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico optimization of analogs derived pro‐adrenomedullin peptide to evaluate antimicrobial potential
Authors: Quigua‐Orozco Raquel M. , Andrade Isadora E. P. , Oshiro Karen G. N. , Rezende Samilla B. , Santos Alexandre Duarte O. , Pereira Julia A. L. , da Silva Viviane G. , Buccini Danieli F. , Porto William F. , Macedo Maria L. R. , Cardoso Marlon H. , Franco Octávio L. 
Published: July 2024

AbstractDiverse computational approaches have been widely used to assist in designing antimicrobial peptides with enhanced activities. This tactic has also been used to address the need for new treatment alternatives to combat resistant bacterial infections. Herein, we have designed eight variants from a natural peptide, pro‐adrenomedullin N‐terminal 20 peptide (PAMP), using an in silico pattern insertion approach, the Joker algorithm. All the variants show an α‐helical conformation, but with differences in the helix percentages according to circular dichroism (CD) results. We found that the C‐terminal portion of PAMP may be relevant for its antimicrobial activities, as revealed by the molecular dynamics, CD, and antibacterial results. The analogs showed variable antibacterial potential, but most were not cytotoxic. Nevertheless, PAMP2 exhibited the most potent activities against human and animal‐isolated bacteria, showing cytotoxicity only at a substantially higher concentration than its minimal inhibitory concentration (MIC). Our results suggest that the enhanced activity in the profile of PAMP2 may be related to their particular physicochemical properties, along with the adoption of an amphipathic α‐helical arrangement with the conserved C‐terminus portion. Finally, the peptides designed in this study can constitute scaffolds for the design of improved sequences.
Associations Between Tinnitus and Systemic Disease in Adolescents: Implications of Vitamin D Deficiency and Anaemia
Authors: Han Sang‐Yoon , Kim Young Ho 
Published: July 2024

ABSTRACTObjectivesTinnitus is one of the irritating symptoms that should be addressed in adolescents. Since tinnitus affects mental health, it is important to treat it. However, identifying the cause of tinnitus is very challenging and the treatment strategies of tinnitus are controversial. The objective of this study was to identify the prevalence of tinnitus in adolescents and systemic diseases as risk factors of adolescent tinnitus to find evidence for new treatment strategies.Materials and MethodsWe extracted the subjects and data using the 5th Korea National Health and Nutrition Examination Survey from 2010 to 2012. One thousand five hundred ninety‐three adolescents with bilateral normal tympanic membranes and availability of the results of physical, laboratory and audiological examinations, were selected. We evaluated their systemic diseases based on these results and assessed the association of tinnitus with demographic factors, systemic diseases and hearing levels.ResultsThe prevalence of tinnitus in Korean adolescents was 21.7%. The hearing level was not associated with tinnitus. Tinnitus was significantly associated with age (p = 0.005), 25(OH)‐D level (p = 0.007) and anaemia (p = 0.003). After controlling the other factors, age (p = 0.045), 25(OH)‐D level (p = 0.041) and anaemia (p = 0.019) were independently related to tinnitus.ConclusionTinnitus in adolescents was significantly associated with age, vitamin D and anaemia. Physicians should consider the higher likelihood of these deficiencies or diseases in adolescent tinnitus patients. Additionally, recognizing these associations may be helpful in developing treatment strategies for adolescent tinnitus.
Overparenting and romantic relationships in emerging adulthood: Roles of relationship efficacy and parent–child relationship quality
Authors: Jiao Chengfei , Cui Ming , Fincham Frank D. 
Published: July 2024

AbstractObjectiveGuided by the theory of emerging adulthood and social cognitive theory, we investigated whether overparenting was associated with romantic relationship quality among emerging adults through relationship efficacy and dependent on parent–child relationship quality.BackgroundEstablishing healthy and lasting intimate relationships is one of the primary developmental tasks during emerging adulthood. Although it is well established that overparenting has negative implications for emerging adults' psychological adjustment, researchers know little about the relationship between overparenting and romantic relationship outcomes during emerging adulthood.MethodThis study used data from a sample of college students (N = 378, Mage = 19.91, SD = 1.23) collected at two time points over a 12‐week interval from a large university in a southeast region of the United States. The majority of the participants were female and White.ResultsResults from structural equation modeling showed that overparenting was negatively associated with later romantic relationship quality through lower relationship efficacy. The negative association between overparenting and relationship efficacy was stronger for those who reported experiencing better parent–child relationship quality.ConclusionOur study further highlights the importance of exploring linkages between overparenting and relational functioning among emerging adults and extends the literature by considering the conceptual context of overparenting through the lens of parent–child relationship quality.ImplicationsPractitioners, therapists, and educators in higher education institutions should promote college students' relational well‐being by highlighting the necessity of considering the role of overparenting behavior in treating or counseling college students' romantic relationship difficulties.
Community members as design partners: Codesign workshops of the families tackling tough times together program
Authors: Rosenberger Claire A. , Elias Cezanne , Ruiz Yumary , Toombs Austin , Lee Sohee , Marceau Kristine , MacDermid Wadsworth Shelley , Kimiecik Carly , Millspaugh Lillian , Cloutier Chloe , Rutherford Lauren , Che Liying , McCormick Carolyn E.B. 
Published: July 2024

AbstractObjectiveThis community‐engaged codesign project identified the changes needed to tailor a family resilience‐building program, the Families Tackling Tough Times Together (FT), into a community setting.BackgroundThere is a need for low‐burden resources to help families mitigate stressful times and build resilience. Guided by Walsh's family resilience framework, FT aims to improve families' ability to cope, recover, and build resilience. Due to the success of FT during the COVID‐19 pandemic, the program is now being modified to help families in the state of Indiana.MethodThree codesign workshops were held with community service providers (CSP) and families. Participants engaged with the FT materials and discussions related to program usability and feasibility. Data were analyzed using a rapid analysis approach.ResultsCSPs stated that FT program materials fit with their goals and workload. Families felt the FT program aligned with their personal needs and day‐to‐day lives. Challenges and concerns with the FT materials included activities that required additional resources or that may be intimidating for families to complete. Both CSPs and families provided helpful suggestions on how to modify the materials.ConclusionThe FT program was well received by participants and was viewed as a valuable addition to the services CSPs offer. Modifications will be made to the FT materials based on knowledge gained from the workshops.ImplicationsThis work highlights the collaborative nature of the codesign process as well as the insights gained from participants regarding the use of the FT materials by CSPs as part of their routine service delivery with families in the community.
The effect of residual stress on high‐cycle fatigue properties and its evaluation method of Ti‐6Al‐4V alloy
Authors: Chang Shuai , Zhang Kun , Tan Jianping , Tu Shantung 
Published: July 2024

AbstractTo assess the contribution of residual stress to the improvement of high‐cycle fatigue (HCF) properties, HCF tests are performed on Ti‐6Al‐4V specimens with different residual stress levels but no other evident surface state modification induced by machining. Results indicate that compressive residual stress induced by machining significantly improves the HCF performance of Ti‐6Al‐4V specimens. Of all the specimens, the fatigue strength of specimens with a surface residual stress level of −400 MPa is increased by approximately 16.4%. Furthermore, to accurately predict the fatigue life based on three mean stress correction equations (e.g., Walker, Goodman, and Smith–Watson–Topper), the method of reducing surface residual stress by a reduction factor and then adding to the mean stress is proposed. A reduction factor of 0.55 is found to be appropriate for the alloy under the test condition, with majority of the predicted data falling within a factor of three scatter band.
Para rubber seed oil and its fatty acids alleviate photoaging and maintain cell homeostasis
Authors: Lourith Nattaya , Kanlayavattanakul Mayuree , Khongkow Mattaka , Chaikul Puxvadee 
Published: July 2024

AbstractObjectivePara rubber seed oil was indicated for skin dullness and hair loss in regard to its cutaneous beneficial fatty acids. Nonetheless, the oil's potency against photoaging remains unexplored. We proposed that para rubber seed oil could alleviate photoaging.MethodsPara rubber seed oil was investigated in cocultures of human HaCaT cells and dermal fibroblasts (HDF). Photoaging protectant efficiency was monitored in terms of IL‐6 and IL‐8 as well as MMP‐1 (collagenase) and MMP‐9 (gelatinase) in a comparison with its fatty acid components.ResultsPara rubber seed oil standardized in fatty acids was indicated as the promising plant oil for photoaging treatment. Its photoprotection mechanism was demonstrated in the coculture system of keratinocyte and fibroblast cells for the first time. Where the oil and its fatty acid constituents (100 μg/mL) were indicated to be safe and efficiently protect the cocultures against UV damage. The oil significantly (p < 0.001) suppressed UV‐induced IL‐6, IL‐8, MMP‐1 and MMP‐9 secretions. The revealed photoprotection proficiency was abided by its fatty acids, particularly the unsaturated C18 ones.ConclusionThe oil was indicated on its potential to maintain skin homeostasis and would alleviate senescence ageing in regard to its photoprotection abilities exhibited. Para rubber seed oil is warranted as a new generation of photoaging protectant agent with the profiled safety and efficacy demonstrated in the epidermal coculture system. The findings encourage the development of innovative anti‐ageing products containing the oil, which is categorizable as a sustainable specialty material for photoaging treatment.
A cross‐sectional study on gender differences in body dysmorphic concerns in patients with skin conditions in relation to sociodemographic, clinical and psychological variables
Authors: Sampogna F. , Samela T. , Abeni D. , Schut C. , Kupfer J. , Bewley A. P. , Finlay A. Y. , Gieler U. , Thompson A. R. , Gracia‐Cazaña T. , Balieva F. , Ferreira B. R. , Jemec G. B. , Lien L. , Misery L. , Marron S. E. , Ständer S. , Zeidler C. , Szabó C. , Szepietowski J. C. , Reich A. , Svensson A. , Altunay I. K. , Legat F. J. , Grivcheva‐Panovska V. , Romanov D. V. , Lvov A. N. , Titeca G. , Vulink N. C. , Tomás‐Aragones L. , van Beugen S. , Evers A. W. M. , Dalgard F. J. ,   European Society for Dermatology and Psychiatry (ESDaP) Study collaborators
Published: July 2024

AbstractBackgroundDysmorphic concern is an overconcern with an imagined or slight defect in physical appearance that can be a symptom of body dysmorphic disorder (BDD). Appearance‐related concerns are frequently reported by people with dermatological conditions. However, relatively little remains known about the relationship between dysmorphic concern and other variables within persons with different skin conditions.ObjectivesThe aim of this multicentre, cross‐sectional study was to investigate gender differences regarding dysmorphic concern and the prevalence of BDD in a large sample of patients with skin conditions, in relation to sociodemographic, clinical and psychological variables.MethodsParticipants aged ≥18 years with skin conditions were consecutively enrolled in dermatological clinics of 22 European centres. Dysmorphic concern and the possible presence of BDD were measured using the Dysmorphic Concern Questionnaire (DCQ) and compared between men and women in relation to sociodemographic, clinical and psychological variables, and separately for each skin condition.ResultsThe DCQ questionnaire was completed by 5290 dermatological patients. In all categories, mean scores were significantly higher in women than in men. Mean DCQ scores were also higher in women for most skin conditions, with the highest effect size in vitiligo. The percentage of patients who screened positive for BDD on the DCQ was 10.5%, 7.7% of men and 12.7% of women. The prevalence of BDD positive was 6.9% in patients with mild clinical severity, 11.1% for moderate and 19.1% for severe condition. In the multivariate model in patients with mild skin condition, the presence of BDD was positively associated with stress and stigma both in men and in women.ConclusionsDysmorphic concern and BDD were more frequent in women than in men with skin conditions. Both received and actual stigmatization might have an impact on body‐related concerns, in particular in women, who may be more at risk for sociocultural reasons.
Tracking the invasive and euryhaline pikeperch Sander lucioperca in the lower River Thames using acoustic telemetry indicates no movements into areas of relatively high salinity
Authors: Stakėnas Saulius , Gregory Stephen D. , Britton J. Robert , Marsh Jessica E. , Tarkan Ali Serhan , Zięba Grzegorz , Wesley Keith J. , Copp Gordon H. 
Published: July 2024

AbstractNative to Central and Eastern Europe, the euryhaline pikeperch Sander lucioperca can acclimatize to elevated salinity levels (e.g., up to 30‰), but it remains unknown whether their invasive populations use this ability to inhabit and/or disperse through brackish waters, such as estuaries and inshore areas. To test whether invasive pikeperch show a propensity to move into areas of relatively high salinity, their spatial use and movement patterns (e.g., home range, distances moved, and movement rates) were assessed using acoustic telemetry in the upper River Thames estuary, southeast England. Analyses revealed that individual pikeperch were capable of moving relatively long distances in a short time (e.g., speeds up to 70 m min−1), with movement patterns associated more with tidal state and elevation at the water surface (both assumed to relate to changes in salinity) than diurnal changes. There were no recorded movements of any pikeperch into the more saline, downstream waters of the estuary where salinity levels were recorded to over 40‰, with the mean salinity in the most downstream area where pikeperch were detected being 1.39‰ (range of logger: 1.22–1.71). The results suggest that these pikeperch did not use high salinity waters when less saline waters were available, and thus the risk that they will use to move through high salinity areas to expand their invasive range appears low. Accordingly, efforts to minimize risks of the further dispersal of invasive pikeperch populations can focus on control and containment programmes within fresh waters.
Monopolar radiofrequency for dermal temperature regulation and remodeling: A porcine model study
Authors: Park Chidae , Hong Jumi , Ryu Hye Guk , Kim Seokhong , Park Jinyoung , Kim Kyung , Won Jongah , Lee Jungmi , Chun Soo Il 
Published: July 2024

AbstractBackgroundNoninvasive monopolar radiofrequency (NMRF) is widely used for dermal and subdermal volumetric heating, yet detailed research on its effects on dermal temperature is scarce.AimsThis study evaluates the impact of NMRF on dermal temperature and its potential for dermal remodeling using a porcine model.MethodsNoninvasive monopolar radiofrequency was applied to porcine skin with temperature monitoring via optic fiber technology and forward‐looking infrared thermal imaging. Safety was evaluated using nitro blue tetrazolium chloride assessments, and effectiveness was determined through histological examinations before and after treatment.ResultsNoninvasive monopolar radiofrequency treatment in a porcine model achieved effective dermal remodeling with no thermal damage, recording peak temperatures of 50°C, 60°C, and 70°C. Histological analysis showed increased collagen density, indicating successful tissue remodeling.ConclusionNoninvasive monopolar radiofrequency is effective in delivering controlled dermal heating and enhancing collagen synthesis, promoting safe and efficient skin tightening and dermal remodeling in a porcine model. It presents a viable option for skin rejuvenation therapies.
Phylogeography and local environmental adaptation in the differentiation of Leptocorisa sister species in East Asia
Authors: Dong Xue , Zhu Xiuxiu , Tang Zechen , Yi Wenbo , Xue Huaijun , Ye Zhen , Zheng Chenguang , Bu Wenjun 
Published: July 2024

AbstractA full understanding of local adaptation at the genomic level will help to elucidate its role in the differentiation between closely related species. This study focused on rice seed bugs sister species (Leptocorisa chinensis and Leptocorisa oratoria), which are native to East Asia and are notorious pests targeting growing rice spikelets. East Asia is a region where diverse geology and fluctuating climate are known to have profound impacts on organisms. In this study, single nucleotide polymorphisms (SNPs) from double‐digest restriction site‐associated DNA sequencing and geographic distribution information were used to investigate phylogeography and assess the environmental contribution to genetic variation. We found clear genetic differentiation between sister species, but a lack of genetic structure within species because of their long‐distance dispersal ability. The demographic model involved a scenario in which divergence in isolation (~0.6 Ma) was followed by secondary contact (~7 kya). The initial divergence may have been caused by the intensification of the East Asian monsoon during the Pleistocene climate oscillation. The historical demography indicated that the effective population size (Ne) showed an evident increase from 9 to 7 kya, which may be related to rice domestication and extensive human cultivation during the Holocene. We also detected a significant correlation between genetic and environmental distance, and the niche difference occupied between them. Temperature‐related variables were ranked as the main factors for the difference, and 410 selective SNPs involved in adaptation were identified. The Nanling Mountains in southern China serve as a geographical boundary between them and act as an ecological barrier belt that promotes local environmental adaptation. Our study demonstrates that historical climate change and local adaptation by climate‐imposed selection shape the phylogeographical patterns of sister species.
Araguainha impact structure, Brazil: New insights into the geology of the central uplift
Authors: Souza Carolinna da Silva Maia de , Hauser Natalia , Reimold Wolf Uwe , Bernardes Renato Borges , Vieira Lucieth Cruz , Guimarães Edi Mendes , Gottwald Manfred 
Published: July 2024

AbstractExtensive, new outcrops along the MT‐100 state road in the northern part of the central uplift of the 40‐km diameter, 252–259 Ma old Araguainha impact structure, Central Brazil, have become available for investigation. They offer new insight into the contact relationships between the different lithologies and the genesis of different types of impact‐related rocks, as well as the current level of erosion of the structure. Three types of impact melt rock (IMR) with different field relationships and compositions can now be distinguished: (1) Type‐I of granitic composition and occurring mainly as veins and dikes, besides a few larger pods, in the central alkali granite core of the central uplift; (2) Type‐II in the form of plastically deformed clasts of mainly highly silicious compositions in polymict impact breccia; and (3) Type‐III, derived from partially melted conglomerate or sandstone precursors, and that occurs at selected sites in (meta)sedimentary strata of the basement in the immediate environs of the alkali granite core. Both polymict lithic and melt‐bearing (suevitic) impact breccias are recognized in the 110‐m thick integrated section through impact breccia directly overlying the crater floor. This crater floor is composed of (meta)‐sedimentary basement strata with granite injections and, locally, sandstones of the Devonian sedimentary Furnas Formation of the Paraná Basin. Main breccia components are (meta)‐pelites and (meta)sandstones of the basement that is currently favored to be related to the regional Paraguay Belt and to the lower sequence of the Paraná Basin sedimentary strata. Locally, breccia contains clasts of IMR Type‐II, and only very rarely are granitic fragments observed. Clasts of IMR Type‐I have never been observed in the breccia deposits. These new observations preclude significant involvement of alkali granite in the formation of the polymict breccia or in the production of shock melts. They also reveal the major role of the (meta)sedimentary precursors in the production of IMR by shock melting and provide essential information for better understanding the cratering processes involved in the formation of an impact structure in a sedimentary target, of the size of the Araguainha impact structure.
Mechanism of azole resistance in Candida vulturna, an emerging multidrug resistant pathogen related with Candida haeumulonii and Candida auris
Authors: Macedo Daiana , Berrio Indira , Escandon Patricia , Gamarra Soledad , Garcia‐Effron Guillermo 
Published: July 2024

AbstractBackgroundCandida vulturna is an emerging pathogen belonging to the Metshnikowiaceae family together with Candida auris and Candida haemulonii species complex. Some strains of this species were reported to be resistant to several antifungal agents.ObjectivesThis study aims to address identification difficulties, evaluate antiungal susceptibilities and explore the molecular mechanisms of azole resistance of Candida vulturna.MethodsWe studied five C. vulturna clinical strains isolated in three Colombian cities. Identification was performed by phenotypical, proteomic and molecular methods. Antifungal susceptibility testing was performed following CLSI protocol. Its ERG11 genes were sequenced and a substitution was encountered in azole resistant isolates. To confirm the role of this substitution in the resistance phenotype, Saccharomyces cerevisiae strains with a chimeric ERG11 gene were created.ResultsDiscrepancies in identification methods are highlighted. Sequencing confirmed the identification as C. vulturna. Antifungal susceptibility varied among strains, with four strains exhibiting reduced susceptibility to azoles and amphotericin B. ERG11 sequencing showed a point mutation (producing a P135S substitution) that was associated with the azole‐resistant phenotype.ConclusionsThis study contributes to the understanding of C. vulturna's identification challenges, its susceptibility patterns, and sheds light on its molecular mechanisms of azole resistance.