bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall survival advantage with partial nephrectomy: A bias of observational data?
Authors: Shuch Brian , Hanley Janet , Lai Julie , Vourganti Srinivas , Kim Simon P. , Setodji Claude M. , Dick Andrew W. , Chow Wong‐Ho , Saigal Chris ,   the Urologic Diseases in America Project
Published: May 2013

BACKGROUNDPartial nephrectomy (PN) and radical nephrectomy (RN) are standard treatments for a small renal mass. Retrospective studies suggest an overall survival (OS) advantage, however a randomized phase 3 trial suggests otherwise. The effects of both surgical modalities on OS were evaluated compared with controls.METHODSA matched cohort study was performed using the Surveillance, Epidemiology, and End Results (SEER)‐Medicare dataset. Individuals treated with PN or RN for localized renal cell carcinoma (RCC) measuring ≤4 cm were compared with 2 control groups (non–muscle‐invasive bladder cancer (BCC) and noncancer controls (NCC). Using a greedy algorithm, RCC groups were matched with controls by demographics and comorbidities. OS for surgical groups and controls were compared. The cause of death was evaluated for cancer groups when differences in OS were noted.RESULTSPatients undergoing PN and RN were matched with controls. All cancer groups had >95% 10‐year cancer‐specific survival (CSS). Median OS was similar between RN (9.05 years) and BCC (8.67 years; P = .067) and NCC (8.77 years; P = .49). Median OS was improved for PN (10.45 years) compared with BCC (8.75 years; P<.001) and NCC controls (8.76 years; P<.001). A multivariate Cox hazards model demonstrated that PN improved OS compared with NCC (hazard ratio, 1.257; P<.001) and BCC (hazard ratio, 1.364; P<.001).CONCLUSIONSRN patients had similar OS compared with controls, suggesting that this treatment modality does not compromise survival. Patients undergoing PN had improved OS compared with controls, suggesting possible selection bias. The apparent survival advantage conferred by PN in SEER‐Medicare case series is likely the result of selection bias involving unmeasured confounders. Cancer 2013;119:2981—2989. © 2013 American Cancer Society.
A Multiple‐Dose, Randomized, Double‐Blind, Placebo‐Controlled, Parallel‐Group QT/QTc Study to Evaluate the Electrophysiologic Effects of THC/CBD Spray
Authors: Sellers Edward M. , Schoedel Kerri , Bartlett Cindy , Romach Myroslava , Russo Ethan B. , Stott Colin G. , Wright Stephen , White Linda , Duncombe Paul , Chen Chien‐Feng 
Published: May 2013

AbstractDelta‐9‐tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray has proved efficacious in the treatment of spasticity in multiple sclerosis and chronic pain. A thorough QT/QTc study was performed to investigate the effects of THC/CBD spray on electrocardiogram (ECG) parameters in compliance with regulatory requirements, evaluating the effect of a recommended daily dose (8 sprays/day) and supratherapeutic doses (24 or 36 sprays/day) of THC/CBD spray on the QT/QTc interval in 258 healthy volunteers. The safety, tolerability, and pharmacokinetic profile of THC/CBD spray were also evaluated. Therapeutic and supratherapeutic doses of THC/CBD spray had no effect on cardiac repolarization with primary and secondary endpoints of QTcI and QTcF/QTcB, respectively, showing similar results. There was no indication of any effect on heart rate, atrioventricular conduction, or cardiac depolarization and no new clinically relevant morphological changes were observed. Overall, 19 subjects (25.0%) in the supratherapeutic (24/36 daily sprays of THC/CBD spray) dose group and one (1.6%) in the moxifloxacin group withdrew early due to intolerable AEs. Four psychiatric serious adverse events (AEs) in the highest dose group resulted in a reduction in the surpatherapeutic dose to 24 sprays/day. In conclusion, THC/CBD spray does not significantly affect ECG parameters. Additionally, THC/CBD spray is well tolerated at therapeutic doses with an AE profile similar to previous clinical studies.
CPU–GPU hybrid parallel strategy for cosmological simulations
Authors: Wang Yueqing , Dou Yong , Guo Song , Lei Yuanwu , Zou Dan 
Published: May 2013

SUMMARYGadget is a simulation application for N‐body and smoothed particle hydrodynamics problems in cosmology, and it is widely applied in solving series of cosmological problems. N‐body focuses on the motion of the interaction of N particles, and smoothed particle hydrodynamics is a fluid simulation algorithm that studies the movement of fluid through particle simulation. Most scholars focus their attention on accelerating Gadget on multi‐core CPU or graphics processing units (GPUs) platforms. However, these research activities failed to achieve CPU–GPU hybrid computing, which resulted in tremendous waste of CPU computing resources.In this paper, we propose a CPU–GPU hybrid parallel strategy to accelerate Gadget‐2, a massively parallel structure formation code for cosmological simulations. This strategy uses CPU and GPU to process the calculation of short‐range force. To ensure CPU and GPU workload balance, a dynamic task allocation scheme is proposed according to the computational performance difference between the CPU and GPU.Experimental results showed that our CPU–GPU hybrid parallel strategy achieved an overall speedup factor of 18.6 and a partial speedup factor for short‐range force calculation of 28.35 compared with a single‐core CPU implementation for particles in million‐size magnitudes. Moreover, compared with a GPU platform that contained 12 CPU cores and one GPU, our hybrid parallel strategy obtained overall speedup and partial speedup factors of 6% and 20%, respectively. Furthermore, the scalability of the hybrid strategy is very fine – its performance will be enhanced when the problem scale is increasing. However, this strategy also has its limitation that the performance enhancement will be decreasing if the ratio(the number of CPU cores divides that of the GPU cards) reduces. Finally, in our hybrid strategy, the CPU coefficient of utilization improved by 17.14% or better. Copyright © 2013 John Wiley & Sons, Ltd.
Kinetic and Thermodynamic Hysteresis Imposed by Intercalation of Proflavine in Ferrocene‐Modified Double‐Stranded DNA
Authors: Gebala Magdalena , La Mantia Fabio , Schuhmann Wolfgang 
Published: May 2013

AbstractSurface‐confined immobilized redox species often do not show the expected zero peak separation in slow‐scan cyclic voltammograms. This phenomenon is frequently associated to experimental drawbacks and hence neglected. However, a nonzero peak separation, which is common to many electrochemical systems with high structural flexibility, can be rationally assigned to a thermodynamic hysteresis. To study this phenomenon, a surface‐confined redox species was used. Specifically, a DNA strand which is tagged with ferrocene (Fc) moieties at its 5′ end and its complementary capture probe is thiolated at the 3′ end was self‐assembled in a monolayer at a Au electrode with the Fc moieties being located at the bottom plane of the double‐stranded DNA (dsDNA). The DNA‐bound Fc undergoes rapid electron transfer with the electrode surface as evaluated by fast scan cyclic voltammetry. The electron transfer is sensitive to the ion transport along the DNA strands, a phenomenon which is modulated upon specific intercalation of proflavine into surface‐bound dsDNA. The electron transfer rate of the Fc0/+ redox process is influenced by the cationic permselectivity of the DNA monolayer. In addition to the kinetic hindrance, a thermodynamic effect correlated with changes in the activity coefficients of the Fc0/+ moieties near the gold‐dsDNA interface is observed and discussed as source of the observed hysteresis causing the non‐zero peak separation in the voltammograms.
Design and implementation of a high‐efficiency bidirectional DC‐DC Converter for DC micro‐grid system applications
Authors: Chiu Huang‐Jen , Lo Yu‐Kang , Kuo Shu‐Wei , Cheng Shih‐Jen , Lin Feng‐Tsuen 
Published: May 2013

ABSTRACTThis paper studies the design and implementation of a non‐isolated dual‐half‐bridge bidirectional DC‐DC converter for DC micro‐grid system applications. High efficiency can be achieved under wide‐range load variations by the zero‐voltage‐switching features and an adaptive phase‐shift control method. A three‐stage charging scheme is designed to meet the fast‐charging demand and prolong the lifetime of LiFePO4 batteries. A digital‐signal‐processing control IC is used to realize the power flow control, DC‐bus voltage regulation, and battery charging/ discharging of the studied bidirectional DC‐DC converter. Finally, a 10 kW prototype converter with Enhanced Controller Area Network communication function is built and tested for micro‐grid system applications. A light‐load efficiency over 96% and a rated‐load efficiency over 98% can be achieved. Copyright © 2013 John Wiley & Sons, Ltd.
Ion Beam Driven High Energy Density Physics Studies at FAIR at Darmstadt: The HEDgeHOB Collaboration
Authors: Tahir N. A. , Shutov A. , Zharkov A. P. , Spiller P. , Piriz A. R. , Rodriguez Prietoc G. , Deutsch C. , Stöhlker Th. 
Published: May 2013

AbstractHigh Energy Density (HED) physics spans over numerous areas of basic and applied physics, for example, astrophysics, planetary physics, geophysics, inertial fusion and many others. Due to this reason, it has been a subject of very active research over the past many decades. Static as well as dynamic methods have been applied to generate samples of HED matter in the laboratory. The most commonly used tool in the static techniques is the diamond anvil cell while the dynamic methods involve shock compression of matter. During the past fifteen years, great progress has been made on the development of bunched intense particle beams that have emerged as an additional new tool for studying HED physics. In this paper we present two experiment designs that have been worked out for HED physics studies at the Facility for Antiprotons and Ion Research (FAIR) at Darmstadt. This facility has entered into construction phase and will provide one of the largest and most powerful particle accelerators in the world. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Study of the Dust‐Free Region Near an Electric Probe and the Dust Particles Oscillations in Dusty Plasma
Authors: Dzhumagulova K. N. , Ramazanov T. S. , Ussenov Y. A. , Dosbolayev M. K. , Masheeva R. U. 
Published: May 2013

AbstractIn this paper we consider the behavior of the dust particles around the electric probe with a negative potential. The size of the dust‐free region, which depends on the probe potential, was experimentally determined. Theoretical calculation of the size of the dust‐free region based on the energy balance was performed. Comparison of theoretical estimations with experimental results was made.Also in this work the results of the theoretical investigation of the oscillations of the dust particles based on the Fourier analysis of the velocity autocorrelation functions are presented. It is shown that real and imaginary parts of the spectral function have maximum near the plasma frequency of the dust particles at large values of coupling parameter and small values of friction coefficient. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Temperature‐Dependent Quantum Pair Potentials and Ionization in Helium‐Like Plasmas
Authors: Rahal H. , Deutsch C. , Gombert M. M. 
Published: May 2013

AbstractDiffraction corrected effective and Coulomb electron‐ion interactions are worked out for helium‐like ions in plasmas of warm dense matter concern, through explicit wave functions derived within a suitable quantum defect frame work. Very significant departures from the corresponding and usual hydrogen‐like expressions are reported. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis and Characterization of Half‐Sandwich Ruthenium Complexes Containing Aromatic Sulfonamides Bearing Pyr­id­inyl Rings: Catalysts for Transfer Hydrogenation of Acetophenone Derivatives
Authors: Dayan Serkan , Ozpozan Kalaycioglu Nilgun , Daran Jean‐Claude , Labande Agnès , Poli Rinaldo 
Published: May 2013

AbstractN‐(Quinoline‐8‐yl‐aryl)benzenesulfonamides 1–6 were successfully synthesized by the reaction of 8‐aminoquinoline and various benzenesulfonyl chlorides. Then, half‐sandwich ruthenium complexes 7–12 were prepared from the reactions of 1–6 with [RuCl2(p‐cymene)]2. The synthesized compounds were characterized by NMR and FTIR spectroscopy and elemental analysis, and compounds 8 and 9 were further analyzed by X‐ray diffraction. The complexes were screened for their efficiency as catalysts in the transfer hydrogenation of acetophenone derivatives to phenylethanols in the presence of KOH with 2‐propanol (as hydrogen source) at 82 °C, and they all showed good activity. Complexes 10 and 12 were the most active (turnover frequency values: 703 and 734 h–1, respectively).
Donor–Acceptor Complexes of Normal and Abnormal N‐Heterocyclic Carbenes with Group 13 (B, Al, Ga) Elements: A Combined DFT and Atoms‐in‐Molecules Study
Authors: Sarmah Satyajit , Guha Ankur Kanti , Phukan Ashwini K. 
Published: May 2013

AbstractDonor–acceptor interactions play a dominant role in descriptions of various chemical systems. The interactions of main‐group Lewis bases with main‐group Lewis acids has attracted interest for many years. In this article, donor–acceptor interactions in NHC–EX3 (NHC = normal and abnormal N‐heterocyclic carbene; E = B, Al, Ga; X = H, F, Cl, OH, NH2, CH3, CF3) adducts have been investigated within the realms of DFT and atoms‐in‐molecules (AIM) theory. Substituents attached to the E atom have a profound effect on the strength and dissociation energies of the NHC–E bond. AIM analysis suggests that these donor–acceptor bonds have significant covalent character, which follows the order Al < Ga < B.
Application of the 2‐Nitrobenzyl Group in Glycosylation Reactions: A Valuable Example of an Arming Participating Group
Authors: Buda Szymon , Gołębiowska Patrycja , Mlynarski Jacek 
Published: May 2013

AbstractThe application of the o‐nitrobenzyl (oNBn) group is demonstrated. This practical methodology allows the stereocontrolled synthesis of glucosides with a 1,2‐trans linkage. This new ether‐type arming group can broadly extend the concept of the use of participating groups in glycosylation reactions. Easy protection and deprotection of the oNBn group further confirms its usefulness in synthesis.
Molecules in Motion: From Sub‐Nanoscale to Macroscale
Authors: Jin Yuhuan , Rack Jeffrey J. 
Published: May 2013

AbstractRuthenium polypyridine complexes comprising sulfoxide ligands show dramatic photochromic behavior based on phototriggered S→O and O→S isomerization. Quantum yields of isomerization can be large, indicating that the excited‐state bond‐breaking and bond‐making reactions are efficient. Ultrafast transient absorption spectroscopy reveals both adiabatic and non‐adiabatic isomerization mechanisms. Incorporation of these complexes within polymer matrices leads to macroscopic bending of the polymer in an example of a direct transduction of photonic energy to mechanical energy.
Castor oil polymer induces bone formation with high matrix metalloproteinase‐2 expression
Authors: Saran Wallace Rocha , Chierice Gilberto Orivaldo , da Silva Raquel Assed Bezerra , de Queiroz Alexandra Mussolino , Paula-Silva Francisco Wanderley Garcia , da Silva Léa Assed Bezerra 
Published: May 2013

AbstractThe aim of this study was to evaluate the modulation of matrix metalloproteinase‐2 (MMP‐2) and −9 (MMP‐9) expression in newly formed bone tissue at the interface between implants derived from castor oil (Ricinus communis) polymer and the tibia medullary canal. Forty‐four rabbits were assigned to either Group 1 (n = 12; control) or Group 2 (n = 30), which had the tibial medullary canals reamed bilaterally and filled with polymer. CT scans showed no space between the material surface and the bone at the implant/bone marrow interface, and the density of the tissues at this interface was similar to the density measured of other regions of the bone. At 90 days postimplantation, the interface with the polymer presented a thick layer of newly formed bone tissue rich in osteocytes. This tissue exhibited ongoing maturation at 120 and 150 days postimplantation. Overall, bone remodeling process was accompanied by positive modulation of MMP‐2 and low MMP‐9 expression. Differently, in control group, the internal surface close to the medullary canal was lined by osteoblasts, followed by a bone tissue zone with few lacunae filled with osteocytes. Maturation of the tissue of the medullary internal surface occurred in the inner region, with the bone being nonlamellar. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 324–331, 2014.
Fabrication of polystyrene microscale porous substrate and its effects on HL‐7702 cells behaviors
Authors: Bi Sixin , Yang Ning , Yang Miaokun , He Xiaoling , Chen Li , Zhu Zhengyan , Gao Yingtang , Du Zhi 
Published: May 2013

AbstractA novel polystyrene (PS) substrate with microscale porous structure was facilely fabricated by crystalline‐controlled casting method using mixed solvent [N,N‐dimethylformamide and ethyl alcohol (v/v)] based on the nonsolvent induced phase separation process. The substrate surfaces exhibited a bi‐continuous microscale porous morphology with high porosity, large pore size and pore–pore connection structure. Moreover, behaviors of the normal human liver cell line (HL‐7702) seeded on this substrate surface were carefully investigated. The results indicated that the cell adhesion, spread and cell–cell connection on the surface with subcellular pore size (∼10 μm) were similar to the cells proliferated on the flat PS surface. However, the number of HL‐7702 cells proliferated on the PS microscale porous surface was higher than cells on the conventional PS flat surface, suggesting that the pore–pore structure was conducive to HL‐7702 cell proliferation. Furthermore, hematoxylin and eosin staining and micronucleus test were performed. The results showed that fewer damages for nuclear and cytoplasm and less cell genotoxicity were caused by the microscale porous structure within the scope of pore size (∼10 μm) than that of the flat surface. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1518–1526, 2014.
Purification and Partial Characterization of a Novel Neurotoxic Protein from Eggs of Black Widow Spiders (Latrodectus tredecimguttatus)
Authors: Li Jianjun , Yan Yizhong , Wang Jirong , Guo Tianyao , Hu Weijun , Duan Zhigui , Wang Xianchun , Liang Songping 
Published: May 2013

ABSTRACTUp to now, there have been a few reports on the toxic components purified from black widow spider (Latrodectus tredecimguttatus) eggs. In the present study, a novel neurotoxic protein was purified from the eggs by gel filtration combined with ion‐exchange chromatography. Its molecular weight was 23.752 kDa determined by electrospray mass spectrometry. The protein could block the neuromuscular transmission in mouse‐isolated phrenic nerve‐hemidiaphragm preparations completely in a reversible manner and activate tetrodotoxin‐sensitive sodium current in rat dorsal root ganglion cells. The N‐terminal sequence of the protein was identified by the Edman degradation to be N‐S‐I‐A‐D‐D‐R‐Y‐R‐W‐P‐G‐Y‐P‐G‐A‐G‐L‐I‐P‐Y‐I‐I‐D‐S—. When the sequence was used to search against protein database with a sequence query in Mascot engine there was no matched sequence or protein whereas the Basic Local Alignment Search Tool (BLAST) analysis indicated that no significant similarity was found. These results demonstrated that the protein (named Latroeggtoxin‐I) is a novel neurotoxic protein purified from the eggs of black widow spiders. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:337‐342, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21493
Impact of overestimated ENSO variability in the relationship between ENSO and East Asian summer rainfall
Authors: Fu Yuanhai , Lu Riyu , Wang Huijun , Yang Xiuqun 
Published: May 2013

AbstractEl Niño–Southern Oscillation (ENSO) events in the preceding winter are an important predictor used to forecast the subsequent East Asian summer rainfall (EASR). This study investigates the relationship between the preceding winter ENSO and the EASR in coupled general circulation models, by analyzing the simulated results of 18 Coupled Model Intercomparison Project Phase 3 models. It is found that more than half of these models can approximately reproduce the ENSO's delayed impact on the EASR, and five models can capture the significant ENSO–EASR relationship. All of these five models overestimate the intensity of the ENSO variability, and they are almost the models that most seriously overestimate the ENSO variability, strongly suggesting that overestimated ENSO variability can help coupled models reproduce the relationship between the ENSO and EASR. Further analyses indicate that all of the five “best” models also overestimate the intensity of tropical Indian Ocean sea surface temperature (SST) variability, and they simulate the strongest intensity of Indian Ocean SST variability among the 18 models.
Recognition of the Minoan tephra in the Acigöl Basin, western Turkey: implications for inter‐archive correlations and fine ash dispersal
Authors: SULPIZIO R. , ALÇIÇEK M. C. , ZANCHETTA G. , SOLARI L. 
Published: May 2013

ABSTRACTHere we report the recognition of the Minoan tephra layer in the Acigöl Basin (western Turkey), which represents the most eastward occurrence of this tephra on land and the first in continental deposits out of lacustrine sediments in mainland Turkey. The correlation is supported by glass and mineral geochemistry, which includes solution and laser‐ablation ICP‐MS data for trace and rare earth elements. Thickness and grain size data allow the extension of already described occurrences to an area of about 359 000 km2, from the eastern Mediterranean to Black Sea throughout central–western Turkey. Coupling dispersal area and grain‐size data suggests the joint influence of high and low atmosphere dynamics in dispersal of fine ash during volcanic eruptions. The thickness and lateral continuity of the Minoan tephra in the Acigöl Basin testifies to the widespread impact on the Late Bronze Age environment of mainland Turkey of this important ash deposit. Copyright © 2013 John Wiley & Sons, Ltd.