bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Chinese Nursing Students Perception in Cardiopulmonary Preparedness: An Observation Descriptive Study
Authors: (Em Ma) Ma Ping , Baylon III Vicente T. , Yukang Wang , Hansong Zhang 
Published: July 2024

The aim of the study was to assesses the preparedness of Chinese Nursing students in cardiopulmonary resuscitation from selected sections of Weifang University of Science and Technology. This assessment entails the identification of the preparedness of Weifang University of Science and Technology nursing students to perform Basic life Support in Cardiopulmonary Resuscitation when needed in the university, community, and hospital setting.
Aim: The primary aim of this research was to assess the perception of Chinese nursing students on basic life support. The specific objective of this study was to evaluate the level of Chinese Nursing students when it comes to Cardiopulmonary Resuscitation preparedness in order to determine their capability during emergency situations. This study was focused on 309 Chinese Nursing students from various levels of education at Weifang University of Science and Technology, a provincial public undergraduate and tertiary vocational college in Weifang, Shandong, China.
Scope and Limitation of the Study: This study focused on the preparedness of Chinese nursing students to perform Cardiopulmonary Resuscitation. The study was conducted at Weifang University of Science and Technology focusing on 309 Chinese Nursing students from different levels of education such as Associate Degree, Bachelor's, Master's Degree, and PhD degrees.
Research Design: The researchers used descriptive nonparametric and Qualtrics online survey tools to assess the perception of the respondents on critical steps on basic life support critical steps and whether it is important or not important. Online perceived “Performance Evaluation Tool” was used to assess respondents’ perceived performance on Critical Steps of Basic Life Support in Cardiopulmonary Resuscitation.
Results: Mainstream of the Chinese nursing students perceived can perform the critical steps of Cardiopulmonary Resuscitation with a mean score of 97.31 percent while the ones who cannot perform is 2.69 percent.
Conclusion: Chinese nursing students' preparedness is essential in emergent Basic Life Support - Cardiopulmonary Resuscitation. The mean score for parameters on critical step perceived can perform with a score of 97.31 percent. This high percentage of perceived performance can help the chance of survival and this perception can strengthen the Chinese students to do their task in emergency situations.
Host Responses in Human Skin After Conventional Intradermal Injection or Microneedle Administration of Virus‐Like‐Particle Influenza Vaccine
Authors: Pearton Marc , Pirri Daniela , Kang Sang‐Moo , Compans Richard W. , Birchall James C. 
Published: April 2013

AbstractMiniaturized microneedle devices are being developed for painlessly targeting vaccines to the immune cell populations in skin. As skin immunization studies are generally restricted to animal models however, where skin architecture and immunity is greatly different to human, surprisingly little is known about the local human response to intradermal (ID) vaccines. Here surgically excised human skin is used to explore for the first time the complex molecular and cellular host responses to a candidate influenza vaccine comprising nanoparticulate virus‐like‐particles (VLPs), administered via conventional hypodermic injection or reduced scale microneedles. Responses at the molecular level are determined by microarray analysis (47,296 discrete transcripts) and validated by quantitative PCR (96 genes). Cellular response is probed through monitoring migration of dendritic cells in viable skin tissue. Gene expression mapping, ontological analysis, and qPCR reveal up‐regulation of a host of genes responsible for key immunomodulatory processes and host viral response, including cell recruitment, activation, migration, and T cell interaction following both ID and microneedle injection of VLPs; the response from the microneedles being more subtle. Significant morphological and migratory changes to skin dendritic cells are also apparent following microneedle VLP delivery. This is the first study displaying the global, multifaceted immunological events that occur at the site of vaccine deposition in human skin and will subsequently influence the degree and nature of innate and adaptive immune responses. An increased understanding of the detailed similarities and differences in response against antigen administered via different delivery modalities will inform the development of improved vaccines and vaccine delivery systems.
Palladium N‐Heterocyclic Carbene Catalysts for the Ultrasound‐Promoted Suzuki–Miyaura Reaction in Glycerol
Authors: Azua Arturo , Mata Jose A. , Heymes Pauline , Peris Eduardo , Lamaty Frederic , Martinez Jean , Colacino Evelina 
Published: April 2013

AbstractNovel palladium N‐heterocyclic‐carbene (NHC)‐based complexes with 3,4,5‐trimethoxybenzyl, alkyl and sulfonate N‐substituents were obtained and fully characterized. The new complexes were used as pre‐catalysts in the Suzuki–Miyaura coupling of various aryl halides/boron sources in glycerol under pulsed‐ultrasound (P‐US) activation. High yields were obtained under mild reaction conditions, without formation of undesired by‐products. The pure final cross‐coupling products were easily recovered without column chromatography and the catalytic/solvent system could be recycled. TEM (transmission electron microscopy) and XPS (X‐ray photoelectron spectroscopy) were used to characterize the nanoparticles and to investigate the fate of the catalysts.
Enantioselective Synthesis of 4‐Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)‐Catalyzed Conjugate Addition of Terminal Alkynes
Authors: Blay Gonzalo , Muñoz M. Carmen , Pedro José R. , Sanz‐Marco Amparo 
Published: April 2013

AbstractA new enantioselective catalyst for the conjugate addition of terminal alkynes has been developed. Terminal alkynes react with 3‐alkoxycarbonylcoumarins in the presence of diethylzinc and bis(hydroxyamide) ligands to give chiral non‐racemic dihydrocoumarins substituted with an alkynyl group on the C‐4 position with good yields and enantiomeric excesses up to 95%.
Copper‐Catalyzed Selective Oxidative Acylation of Secondary Anilines with Ethyl Glyoxalate: Domino Synthesis of Indoline‐2,3‐diones
Authors: Liu Tao , Yang Haijun , Jiang Yuyang , Fu Hua 
Published: April 2013

AbstractA novel, easy and useful copper‐catalyzed selective acylation of secondary anilines with ethyl glyoxalate has been developed, and the corresponding indoline‐2,3‐dione derivatives were prepared. The procedure comprises the sequential intermolecular copper‐catalyzed selective oxidative ortho‐site aromatic acylation of the NH group in secondary anilines and intramolecular nucleophilic attack of the NH group to the ester. The inexpensive, easy and efficient method should provide a new strategy for synthesis of dicarbonyl compounds.
Enantioselective N‐Heterocyclic Carbene‐Catalyzed Annulations of 2‐Bromoenals with 1,3‐Dicarbonyl Compounds and Enamines via Chiral α,β‐Unsaturated Acylazoliums
Authors: Yetra Santhivardhana Reddy , Bhunia Anup , Patra Atanu , Mane Manoj V. , Vanka Kumar , Biju Akkattu T. 
Published: April 2013

AbstractThe N‐heterocyclic carbene (NHC)‐catalyzed generation of chiral α,β‐unsaturated acylazoliums from 2‐bromoenals followed by their interception with 1,3‐dicarbonyl compounds or enamines, the formal [3+3] annulation reaction, is reported. The reaction results in the enantioselective synthesis of synthetically and medicinally important dihydropyranones and dihydropyridinones, and tolerates a wide range of functional groups. It is noteworthy that the reaction takes place under mild reaction conditions utilizing relatively low catalyst loadings. In addition, based on DFT calculations, a mechanistic scenario involving the attack of the nucleophile from below the plane of the α,β‐unsaturated acylazoliums, and the mode of enantioinduction is presented.
Enhanced degradation of haloacid by heterologous expression in related Burkholderia species
Authors: Su Xianbin , Deng Liyu , Kong Ka Fai , Tsang Jimmy S. H. 
Published: April 2013

ABSTRACTHaloacids are environmental pollutant and can be transformed to non‐toxic alkanoic acids by microbial dehalogenase. Bacterium Burkholderia species MBA4 was enriched from soil for its ability to bioremediate haloacids such as mono‐chloroacetate (MCA), mono‐bromoacetate (MBA), 2‐mono‐chloropropionate, and 2‐mono‐bromopropionate. MBA4 produces an inducible dehalogenase Deh4a that catalyzes the dehalogenation process. The growth of MBA4 on haloacid also relies on the presence of a haloacid‐uptake system. Similar dehalogenase genes can be found in the genome of many related species. However, wildtype Burkholderia caribensis MWAP64, Burkholderia phymatum STM815, and Burkholderia xenovorans LB400 were not able to grow on MCA. When a plasmid containing the regulatory and structural gene of Deh4a was transformed to these species, they were able to grow on haloacid. The specific enzyme activities in these recombinants ranges from 2‐ to 30‐fold that of MBA4 in similar condition. Reverse transcription‐quantitative real‐time PCR showed that the relative transcript levels in these recombinant strains ranges from 9 to over 1,600 times that of MBA4 in similar condition. A recombinant has produced nearly five times of dehalogenase that MBA4 could ever achieve. While the expressions of Deh4a were more relaxed in these phylogenetically related species, an MCA‐uptake activity was found to be inducible. These metabolically engineered strains are better degraders than the haloacid‐enriched MBA4. Biotechnol. Bioeng. 2013;110: 2687–2696. © 2013 Wiley Periodicals, Inc.
On the identifiability of copulas in bivariate competing risks models
Authors: Schwarz Maik , Jongbloed Geurt , Van Keilegom Ingrid 
Published: April 2013

AbstractIn competing risks models, the joint distribution of the event times is not identifiable even when the margins are fully known, which has been referred to as the “identifiability crisis in competing risks analysis” (Crowder, 1991). We model the dependence between the event times by an unknown copula and show that identification is actually possible within many frequently used families of copulas. The result is then extended to the case where one margin is unknown. The Canadian Journal of Statistics 41: 291–303; 2013 © 2013 Statistical Society of Canada
Amiodarone and the risk of cancer
Authors: Su Vincent Yi‐Fong , Hu Yu‐Wen , Chou Kun‐Ta , Ou Shuo‐Ming , Lee Yu‐Chin , Lin Elizabeth Ya‐Hsuan , Chen Tzeng‐Ji , Tzeng Cheng‐Hwai , Liu Chia‐Jen 
Published: April 2013

AbstractBACKGROUND:In postmarketing surveillance, the US Food and Drug Administration has reported the development of lung masses, thyroid cancer, and skin cancer after amiodarone therapy.METHODS:Using the Taiwan National Health Insurance Research database, the authors conducted a population‐based cohort study. Patients who were treated with amiodarone between 1997 and 2008 were enrolled. Those with antecedent cancer were excluded. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of the study cohort with that of the general population. A multivariate Cox regression model was used to evaluate the association between cumulative defined daily doses (cDDDs) of amiodarone and cancer occurrence.RESULTS:The study included 6418 subjects, with a median follow‐up of 2.57 years. A total of 280 patients developed cancer. The risk of cancer increased with borderline significance (SIR, 1.12; 95% confidence interval [95% CI], 0.99‐1.26 [P = .067]). Male patients had a higher risk (SIR, 1.18; 95% CI, 1.02‐1.36 [P = .022]). The total cohort of patients and the male patients with > 180 cDDDs within the first year were found to have SIRs of 1.28 (95% CI, 1.00‐1.61; P = .046) and 1.46 (95% CI, 1.11‐1.89; P = .008), respectively. After adjustment for age, sex, and comorbidities, the hazards ratio was 1.98 (95% CI, 1.22‐3.22; P = .006) for the high tertile of cDDDs compared with the low tertile.CONCLUSIONS:The results of the current study indicate that amiodarone may be associated with an increased risk of incident cancer, especially in males, with a dose‐dependent effect. Cancer 2013;119:1699–1705. © 2013 American Cancer Society.
Implied Pricing Kernels: An Alternative Approach for Option Valuation
Authors: Ryu Doojin , Kang Jangkoo , Suh Sangwon 
Published: April 2013

AbstractThis study proposes a new estimation approach for option valuation (an implied pricing kernel‐based approach), which estimates model parameters under the physical probability measure (P‐measure) using a pricing kernel implied by the GARCH option pricing model. Analyzing the dataset on the KOSPI 200 options market, we examine the empirical performance of the implied pricing kernel‐based approach and compare it with the performance of the classical GARCH option valuation approach (i.e., a pricing model‐based approach) that estimates model parameters under the risk‐neutral probability measure (Q‐measure). As proposed in this study, the implied pricing kernel‐based estimation approach requires approximation and discretization in order to derive the functional form of the pricing kernel. Regardless of this approximation, however, when it comes to pricing OTM calls, the implied pricing kernel‐based approach performs slightly better than the pricing model‐based approach that has been traditionally used for option valuation. Additional analysis based on the put option sample indicates that the implied pricing kernel‐based approach clearly dominates the classical pricing model‐based approach during the early stage of emergence of the KOSPI 200 options market (1999–2000) when the market was immature. During the recent global financial crisis (2007–2009), the pricing kernel‐based approach also yields smaller pricing errors for OTM puts than the classical approach does. These empirical results imply that the new approach suggested in this study can be advantageous for option valuation, particularly when the information embedded in options prices is not sufficient for estimation and/or the market is speculative and volatile. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark 35:127–147, 2015
Serum-mediated transgenerational effects on sperm: Evidence for lamarckian inheritance?
Authors: Seki Yoshiyuki , Groszmann Roberto J. , Iwakiri Yasuko , Taddei Tamar H. 
Published: April 2013

Abstract

We investigated whether ancestral liver damage leads to heritable reprogramming of hepatic wound healing in male rats. We found that a history of liver damage corresponds with transmission of an epigenetic suppressive adaptation of the fibrogenic component of wound healing to the male F1 and F2 generations. Underlying this adaptation was less generation of liver myofibroblasts, higher hepatic expression of the antifibrogenic factor peroxisome proliferator-activated receptor g (PPAR-g) and lower expression of the profibrogenic factor transforming growth factor b1 (TGF-b1) compared to rats without this adaptation. Remodeling of DNA methylation and histone acetylation underpinned these alterations in gene expression. Sperm from rats with liver fibrosis were enriched for the histone variant H2A.Z and trimethylation of histone H3 at Lys27 (H3K27me3) at PPAR-g chromatin. These modifications to the sperm chromatin were transmittable by adaptive serum transfer from fibrotic rats to naive rats and similar modifications were induced in mesenchymal stem cells exposed to conditioned media from cultured rat or human myofibroblasts. Thus, it is probable that a myofibroblast-secreted soluble factor stimulates heritable epigenetic signatures in sperm so that the resulting offspring better adapt to future fibrogenic hepatic insults. Adding possible relevance to humans, we found that people with mild liver fibrosis have hypomethylation of the PPARG promoter compared to others with severe fibrosis.
The adaptive hierarchical expansion of the kinetic energy operator
Authors: Strobusch Daniel , Nest Mathias , Scheurer Christoph 
Published: April 2013

AbstractThe hierarchical expansion of the kinetic energy (HEKE) operator in curvilinear coordinates presented recently (Strobusch and Scheurer, J. Chem. Phys. 2011a, 135, 124102; Strobusch and Scheurer, J. Chem. Phys. 2011b, 135, 144101) relies on a many‐body expansion of the metric tensor. It is shown how this expansion can be adapted to a specific system. An analytic formula is derived, which yields an estimate of the impact of a certain expansion term on the spectrum. In combination with the hierarchical structure of the many‐body expansion and interpolation techniques, the memory consumption and evaluation time of the HEKE operator as well as the computational costs for subsequent vibrational self‐consistent field and vibrational configuration interaction calculations are reduced significantly, which is demonstrated by studies on two small test systems H2O2 and formaldehyde (H2CO). © 2013 Wiley Periodicals, Inc.
Effect of graft patency on the prediction of myocardial viability by dobutamine stress and myocardial contrast echocardiography before coronary artery bypass surgery
Authors: Liu Chang , Xiu Chun‐hong , Xiao Xi‐gang , Ni Li‐xin , Liu Zong‐hong , Wang Bai‐chun , Shen Jing‐xia , Zhu Kai , Zhang Guo‐wei , Xu Lei , Liu Hong‐yu 
Published: April 2013

ABSTRACTBackgroundMyocardial functional recovery after revascularization is considered the “gold standard” for myocardial viability (MV) assessment. However, the patency of the revascularized coronary artery affects myocardial functional recovery in patients subjected to coronary artery bypass grafting (CABG). The influence of graft patency on viability results has not been widely studied.PurposeWe evaluated the effect of graft patency on the prediction of MV after CABG by myocardial contrast echocardiography (MCE) and low‐dose dobutamine stress echocardiography (LD‐DSE).MethodsFifty‐three subjects with chronic ischemic heart disease scheduled for CABG were divided randomly into groups A (n = 26) and B (n = 27). They underwent MCE and LD‐DSE preoperatively. Patients were followed up 12 months after CABG. Group B patients underwent multislice computed tomography angiography to assess CABG patency, and patients with obstructed grafts were excluded. Group A patients were not subjected to multislice CT angiography. The accuracy of MCE and LD‐DSE for assessing MV between the two groups was compared.ResultsThe accuracy and positive predictive values of MCE and LD‐DSE for predicting MV were higher in group B than in group A (p < 0.05).ConclusionsPreoperative LD‐DSE and MCE ability to predict MV depends on the patency of CABG. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound 42:9–15, 2014
Ultrastructural and immunohistochemical study of early repair of alveolar sockets after the extraction of molars from alendronate‐treated rats
Authors: Yamamoto‐Silva Fernanda P. , Bradaschia‐Correa Vivian , Lima Luiz A.P.A. , Arana‐Chavez Victor E. 
Published: April 2013

ABSTRACTThe aim of the present research was to analyze ultrastructural and immunohistochemical aspects of the alveolar repair after the extraction of molars of alendronate (ALN)‐treated rats. Wistar rats received 2.5mg/kg body wt/day of ALN during 14 days previously and 7, 14 and 21 days after the extraction of the second mandibular molar. Specimens were fixed in 2% glutaraldehyde + 2.5% formaldehyde under microwave irradiation, decalcified in 4.13% EDTA and paraffin embedded for TRAP histochemistry and immunohistochemistry for OPN, BSP and endoglin, or embedded in Spurr epoxy resin for TEM analysis. Additional specimens had their soft tissues removed and were processed for scanning electron microscopy. The ALN group presented latent TRAP‐positive osteoclasts and nonresorbed alveolar crests with bacterial infection. Mild bone necrosis signs were observed at all time points studied. Ultrastructurally, empty osteocyte lacunae were observed and bone trabeculae surface presented hyalinized aspect. A significant delay in alveolar repair occurred, as well as decreased angiogenesis. ALN treatment provoked mild signs of bone necrosis, despite the high dose employed. The present findings add new information about the ultrastructural aspect of the early repair of rats under ALN treatment and highlight for giving attention when oral surgeries are performed in patients using this drug. Microsc. Res. Tech. 76:633–640, 2013. © 2013 Wiley Periodicals, Inc.
Hydrologic controls on the transport and cycling of carbon and nitrogen in a boreal catchment underlain by continuous permafrost
Authors: Koch J. C. , Runkel R. L. , Striegl R. , McKnight D. M. 
Published: April 2013

AbstractBoreal ecosystems represent a large carbon (C) reservoir and a substantial source of greenhouse gases. Hydrologic conditions dictate whether C leached from boreal soils is processed in catchments or flushed to less productive environments via the stream. This study quantified hydrologic and biogeochemical C loss from a boreal catchment underlain by frozen silt, where flowpaths may deepen as the active layer thaws over the summer. We hypothesized a decrease in the magnitude of C mineralization over the summer associated with changing flowpaths and decreasing hydrologic connectivity, organic matter lability, and nitrogen (N) availability. Conservative tracers were used to partition C and N loss between catchment export and biogeochemical processing. Coupling tracers with tributary and porewater chemistry indicated C and N cycling in soil flowpaths, with an exponential decrease over the summer. Nitrate was primarily reduced in hillslope flowpaths and the lack of N reaching the stream appeared to limit C mineralization. Stream export accounted for the greatest loss of C, removing 247 and 113 mol hr−1 in the early and late summer, respectively. Reactivity was related to hydrologic connectivity between the soils and stream, which was greatest early in the summer and following a large flood. While a warming climate may increase storage potential in thawed soils, the early‐season flush of labile material and late‐season runoff through mineral flowpaths may maintain high C export rates. Therefore, we highlight physical export as a dominant cause of aqueous C loss from silty catchments as the Arctic continues to thaw.