bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systemised literature review into the benefits of introducing the advanced clinical practitioner role to palliative care patients
Authors: Graham Adam , Monk Daniel 
Published: July 2024

Background: By 2040, it is predicted that at least 42% more people will need palliative care services in England and Wales. It is not known if introducing advanced clinical practitioners (ACPs) to palliative care environments is beneficial to patients and healthcare organisations. Aims: This research aims to evaluate if there is a benefit to incorporating ACPs within palliative care environments through data collection on their effectiveness when working in palliative care. Methods: A systemised review of the literature with a narrative synthesis. Findings: The literature shows that the ACP role has positive benefits on palliative care in three domains: (1) for the patient, through improving quality of life; (2) for professionals, through education; and (3) for organisations, through cost-effective models of care. Conclusions: Incorporating the role of the ACP could enable organisations and trusts to deliver new models of care that are both patient-focused and cost-effective. Further research is needed within palliative care on the impact of nurses educated to an MSc level in advanced clinical practice, compared to the traditional role of the clinical nurse specialist.
Examining the feasibility of advanced practice radiation therapy roles within the Singaporean healthcare arena: a joint UK-Singapore study
Authors: Jhagra Robin , Khine Ricardo , Tan Chek Wee , Koh Wee Yao , Goh Lili , Jarvis Carol , Woodley Julie 
Published: July 2024

Background:Advanced clinical practice in UK healthcare has matured over recent years. The field now promotes multi-professional working and flexibility in patient care, which are significant factors of the modern healthcare workforce, due to the ongoing shortage of clinicians nationwide. In radiation oncology, the advanced practitioner radiographer role has been pivotal. Observing a rising necessity for similar roles in Singapore, officials from the National University Health System, Singapore, conducted a scientific visit to the UK to explore the implementation of UK advanced practice radiation therapist roles.Aims:The objective of the trip was to explore and learn about the infrastructure of the advanced practitioner radiographer role in the UK, with a view to establish similar positions in Singapore and improve service delivery within its healthcare system.Methods:During the scientific visit, Singaporean experts engaged in collaborative discussions with UK expert practitioners. These interactions centred on legislative frameworks, their applications and the educational aspects associated with the advanced practitioner radiographer role. The specialists visited various hospitals and a university to gain deeper insights. Following the visit, a survey was conducted among the Singaporean experts to gather comprehensive feedback regarding the visit.Findings:Active participation in the visit led to the researchers gaining a nuanced understanding of the UK's advanced practitioner radiographer role, and whether an equivalent advanced practice radiation therapist framework could be feasibly implemented in Singapore. The insights garnered will be instrumental for strategic planning, addressing service gaps and fostering advancements in Singapore's healthcare system.Conclusion:Adaptive governance of advanced practice is essential. Learning from the UK's intricate models can guide robust policy formulation and professional role development in Singapore. This can help to facilitate the national establishment of advanced practice radiation therapist roles, supported by suitable education and accreditation structures.
Combined metabolomics and transcriptomics reveal the secondary metabolite networks in different growth stages of Bletilla striata (Thunb.) Reichb.f.
Authors: Chen Man , Wang Xia , Ye Yueyu , Li Xiaomei , Li Shiqing , Li Meiya , Jiang Fusheng , Zhang Chunchun 
Published: July 2024

Background
Bletilla striata (Thunb.) Reichb.f. (B. striata) is a traditional Chinese medicinal herb. B. striata polysaccharides (BSP), stilbenes and 2-isobutyl malic acid glucosoxy-benzyl ester compounds are the main active ingredients in B. striata. However, there is limited report on the changes of medicinal components and their biosynthesis regulation mechanisms in the tubers of B. striata at different stages.

Method
The tubers of B. striata were collected during the flowering period, fruiting period, and harvest period to determine the total polysaccharide content using the phenol sulfuric acid method. The changes in secondary metabolites in the tubers at these stages were analyzed by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS), and transcriptomics was conducted for further exploration of their biosynthetic pathways.

Result
The BSP content gradually increases from the flowering period to the fruiting period as the tubers develop, reaching its peak, but subsequently decreases at harvest time, which may be associated with the germination of B. striata buds in later stage. A total of 294 compounds were identified in this study. Among them, a majority of the compounds, such as 2-isobutyl malate gluconoxy-benzyl ester, exhibited high content during the fruit stage, while stilbenes like coelonin, 3’-O-methylbatatasin III, and blestriarene A accumulated during the harvesting period. The transcriptome data also revealed a substantial number of differentially expressed genes at various stages, providing a partial explanation for the complex changes in metabolites. We observed a correspondence between the expression pattern of GDP-Man biosynthesis-related enzyme genes and cumulative changes in BSP. And identified a positive correlation between 9 transcription factors and genes associated with polysaccharide biosynthesis, while 5 transcription factors were positively correlated with accumulation of 2-isobutyl malate gluconoxy-benzyl ester compounds and 5 transcription factors exhibited negative correlated with stilbene accumulation.

Conclusion
It is imperative to determine the appropriate harvesting period based on the specific requirements of different active ingredients and the accumulation patterns of their metabolites. Considering the involvement of multiple transcription factors in the biosynthesis and accumulation of its active ingredients, a comprehensive investigation into the specific regulatory mechanisms that facilitate high-quality cultivation of B. striata is imperative.
Unraveling the role of computed tomography derived body composition metrics on anastomotic leakages rates in rectal cancer surgery: A protocol for a systematic review and meta-analysis
Authors: Broekman Mark , Genders Charlotte M. S. , Geitenbeek Ritchie T. J. , Havenga Klaas , Kruijff Schelto , Klaase Joost M. , Viddeleer Alain R. , Consten Esther C. J. 
Published: July 2024

Introduction
Anastomotic leakage is a major concern following total mesorectal excision for rectal cancer, affecting oncological outcomes, morbidity an treatment costs. Body composition has been suggested to influence anastomotic leakage rates. However, literature on how body composition impact anastomotic leakage rates is conflicting. This systematic review aims to evaluate the role of computed tomography derived body composition metrics on anastomotic leakage rates in rectal cancer patients.

Methods
Databases PubMed/MEDLINE, Cochrane Library, web of science, and EMBASE, will be systematically searched for papers from January 2010 onwards. Study selection, data collection and quality assessment will be independently performed by three research fellows. Outcomes described in three or more studies will be included in the meta-analysis. The Q-test and I2 statistic will be used to assess statistical heterogeneity between studies. Publication bias will be examined by visual inspection of funnel plots and quantified by Egger’s test. Sensitivity analyses will be conducted to examine the robustness of the meta-analysis. Reporting of the findings will be in line with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.

Conclusions
This systematic review will synthesize the current evidence and will identify knowledge gaps. Results of the systematic review will aid health care professional in pre-operative decision making and will be distributed through a peer-reviewed publication and presentation of results at international meetings.

Trial registration
PROSPERO protocol number: CRD42023471537.
TRANSFER OF INTELLECTUAL PROPERTY RIGHT AS A COMPANY ASSET IN BANKRUPTCY IN INDONESIA
Authors: Al Asy'arie Moh. Asadullah Hasan , Rahmanda Bagus , Prasetyo Khanza Anindita 
Published: July 2024

The transfer of intellectual property rights (IPR) as a company asset during bankruptcy proceedings in Indonesia presents a complex legal landscape. This study examines the gap between existing legal frameworks and the practical realities faced by companies undergoing bankruptcy. Specifically, the research addresses the lack of clear guidelines on the valuation, transfer, and protection of IP rights, which are critical assets in the modern economy. This study utilizes the three research methods, which are Normative Approach and Conceptual Approach. Findings indicate significant inconsistencies and ambiguities in the legal treatment of IPR in bankruptcy cases. The aim of this research is to provide an understanding of how IPR can be included in the bankruptcy estate and distributed to entitled creditors based on an assessment by the curator. In conclusion, this research found that recommendations for legal amendments and policy interventions to bridge the identified gaps, thereby enhancing the protection and transferability of IP rights in bankruptcy contexts in Indonesia.
The extraction method used for English–Chinese machine translation corpus based on bilingual sentence pair coverage
Authors: Dang Penghua 
Published: July 2024

Abstract
To improve the effect of corpus extraction in bilingual English–Chinese machine translation (ECMT), this article combines a machine learning algorithm with the ECMT corpus extraction method based on bilingual sentence pair coverage. Aiming at the propagation characteristics of medium- and short-range speeches, and employing multi-band speech waveforms in the troposphere, the actual requirements of remote machine translation are combined with the free-space, 1546, and the dual-path models, respectively, to analyze three typical air-to-ground wave propagation models. A simulation is conducted for both predictions and comparisons. In addition, a radio wave propagation model within the line of sight in the troposphere is established. The results suggest that the improved dual-path model is consistent with the propagation characteristics of radio waves in the troposphere. Moreover, the experiments show that the proposed ECMT corpus extraction method based on bilingual sentence pair coverage can play an important role in more accurate English–Chinese translations.
Ausflug in ein ‚Niemandsland‘ der brandenburgischen Landesgeschichte
Authors: Stegmann Andreas 
Published: July 2024

Zusammenfassung
Die 2022 veröffentlichte Biografie des brandenburgischen Kurfürsten Joachim II. von Mathis Leibetseder ist in mehrfacher Hinsicht problematisch: Ihre Quellenbasis ist zu schmal, sie vernachlässigt die Quellenkritik, sie zeigt Mängel im Umgang mit dem Forschungsdiskurs und sie präsentiert eine fragwürdige Deutung Joachims II. Das umfangreiche Buch bedarf einer kritischen Besprechung und es lädt ein, über den gegenwärtigen Stand der Erforschung der brandenburgischen Landes- und Kirchengeschichte des 16. Jahrhunderts nachzudenken.
Comprehensive review of the heart failure management guidelines presented by the American College of Cardiology and the current supporting evidence
Authors: Lazareva Lia , Shubrook Jay H. , Dhond Milind 
Published: July 2024

Abstract

Context
Heart failure (HF) is a chronic condition that affects the heart's functional capacity, resulting in symptoms such as fatigue, edema, and dyspnea. It affects millions of adults in the United States and presents challenges in optimizing treatment and coordinating care among clinicians. Additionally, the various classifications for HF and limited research on treatment outcomes in heart failure with midrange ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF) further complicate the pharmacological management of patients with this disease.

Objectives
The objectives of this article are to review the pharmacotherapy guidelines for HF provided by the American College of Cardiology (ACC) and offer an update on the current trials conducted on these agents.

Methods
The paper includes a post hoc analysis of established randomized controlled trials (RCTs), current RCTs, analysis of HF registries, and the guidelines published by the ACC. The gathering of research began in June 2023 and completed in August 2023. PubMed was utilized with the following search items: “treatment for HFrEF” (heart failure with reduced ejection fraction), “treatment for HFmrEF,” and “treatment for HFpEF.” The screening process was completed by one author. The automation tools utilized were “clinical trials,” “randomized control trials,” and “five years”. Meta-analyses, systematic reviews, and case reports were excluded from the screening process. This review does not include research regarding medical devices, interventional therapies, and lifestyle modifications. Finally, research regarding additional comorbidities, nonpharmacological focused research, and agents not recommended by the ACC are not included in this paper.

Results
The search began with 6,561 records identified from PubMed, with 407 records screened after automation tools were utilized to filter for “clinical trials,” “randomized control trials,” “one year,” and “five years”. A total of 22 duplicates were reviewed, 318 were sought for screening after trials from 2019 were removed, and 31 studies were ultimately included in the review. A detailed summary of the most recent recommendations by the ACC are provided. The discussion includes indications, mechanisms of action, side effects, and contraindications for the selected agents. Additionally, recent clinical trials are included to provide evidence on the efficacy of the recommended classes of drugs.

Conclusions
The current guidelines for managing HFrEF have been consistent, but there is limited consensus on treating HFmrEF and HFpEF. Large RCTs have provided compelling evidence supporting the use of the recommended pharmacological agents. However, despite the new effective treatment protocols, slow clinical inertia and underoptimization of HF management persist. Thus, it is crucial to synchronize care among clinicians involved in managing patients with this disease.
Fuzzy reliability algorithm for the shutdown system of research reactor
Authors: Selim Hala K. G. 
Published: July 2024

Abstract
Probabilistic safety assessment (PSA) has been applied to evaluate the safety of nuclear reactor systems. The results of PSA are used by designers, utilities and regulatory body to confirm the reactor design, to change operation procedures, to enhance the reliability of safety systems, or to modify regulation. Fault tree analysis (FTA) has been used as a deductive means for PSA. System components are assumed to always have defined failure probabilities; however, in reality this assumption is questionable and sometimes there is insufficient data about the failure probability of some components. To solve this problem, fuzzy approaches have been proposed and implemented. The aim of this study is to apply a fuzzy reliability algorithm to estimate basic events failure probabilities for the shutdown system of a research reactor. The reactor is a 22 MW light water open pool type material test reactor and the shutdown system is responsible for the fast shutdown of the reactor whenever safety limits are exceeded. Then, to illustrate the ability of the algorithm, the results are compared with real basic event failure probabilities. The results verify the competence of the algorithm and confirm that it can be applied as an alternative method when quantitative data are not available. Also, a risk importance measure is done on the fault tree of the shutdown system to illustrate which components need to be focused for improvements to achieve the safe operation of shutdown system.
Reliability analysis of digital reactor protection systems in floating nuclear power plants
Authors: Xie Xi-Wen , Yin Chang-Zheng , Peng Chang-Hong 
Published: July 2024

Abstract
This paper presents a reliability model for digital reactor protection systems (RPSs) in floating nuclear power plants (FNPPs) that accounts for both the internal characteristics of RPS and the external environment. The internal characteristics of RPS include independent failures and common-cause failures (CCFs) of components, repair behavior, and actuation logic degradation. For the external environment, we incorporated a parts-pressure method and used the environmental factors to describe the impact of marine environment at component level. Detailed Monte Carlo simulation (MCS) algorithm was proposed to solve the reliability models with different environmental factors, and the results showed that the maximum value of the environmental factor was 3.2 under the requirements that the probability for RPS failing to generate the trip signal does not exceed 1 × 10−5 and the spurious trip frequency does not exceed one time per year. Reliability indexes, such as failure probability and spurious trip frequency, were also derived. The 90 % confidence intervals of these two indexes were further calculated in the uncertainty analysis by using the kernel density estimation (KDE) approach.
Areal and phylogenetic dimensions of word order variation in Indo-European languages
Authors: Ebert Christian , Bickel Balthasar , Widmer Paul 
Published: July 2024

Abstract
Both areal and phylogenetic affiliation have been discussed as driving factors of the distribution of word order in the languages of the world. However, disentangling the interaction of these two factors is challenging. Here we take Indo-European as a test case. Word order in this family is largely homogeneous both within areas and within branches, which makes it difficult to assess which factor was more important in shaping the present-day distribution. To break out of this impasse we turn to corpus data and explicit statistical modeling. Building on a parallel corpus of movie subtitles, we investigate word order on the sentence level under stable pragmatic conditions. We measure the similarity of word order variation between pairs of languages with an information-theoretic distance metric. Using cluster analysis and variation partitioning methods these distance metrics show that phylogenetic distance predicts more variation than geographical distance, but the most important predictor is the shared fraction where phylogeny and area overlap. We conclude that word order has evolved along both dimensions and cannot be reduced to a single one.
Strafschnelligkeit – die in der empirischen Forschung vernachlässigte Dimension der negativen Generalprävention Bisherige Evidenzen und neue Befunde
Authors: Hirtenlehner Helmut , Leitgöb Heinz 
Published: July 2024

Zusammenfassung
Die Zeitspanne zwischen der Ausführung einer rechtswidrigen Handlung und ihrer Bestrafung markiert ein in der empirischen Abschreckungsforschung stark vernachlässigtes Thema. Während die Konsequenzen der Strafwahrscheinlichkeit und Strafhärte vielfach untersucht wurden, gibt es zur generalpräventiven Bedeutsamkeit der Strafschnelligkeit kaum Befunde. Die vorliegende Arbeit will diesem Ungleichgewicht entgegentreten. Dazu werden im Anschluss an eine Sichtung des einschlägigen Forschungsstands die Ergebnisse einer Szenariostudie zur Vandalismusdelinquenz junger Menschen vorgestellt. Die Resultate lassen keine signifikanten Effekte der Sanktionierungsgeschwindigkeit erkennen. In dem Bereich, in dem das Kriminaljustizsystem eine Verfahrensbeschleunigung leisten kann, scheint eine raschere gerichtliche Bestrafung keine generalpräventiven Erfolge zu bringen.
Synthesis and crystal structure of (Z)-4-((1-(3-fluorophenyl)-1H-1,2,3-triazol-4-yl)methylene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, C19H14FN5O
Authors: Konovalova Irina S. , Geleverya Anna O. , Semenets Anton , Kovalenko Sergiy M. , Reiss Guido J. 
Published: July 2024

Abstract
C19H14FN5O, monoclinic, P21/c (no. 14), a = 7.2944(3) Å, b = 12.2032(5) Å, c = 18.1070(7) Å, β = 95.807(4)°, V = 1603.52(11) Å3, Z = 4, R
gt(F) = 0.0451, wR
ref = 0.1217, T = 100(2) K.
Double diffusion convection of Maxwell–Cattaneo fluids in a vertical slot
Authors: Sun Yanjun , Wang Jialu , Jia Beinan , Chang Long , Jian Yongjun 
Published: July 2024

Abstract
The convection stability of Maxwell–Cattaneo fluids in a vertical double-diffusive layer is investigated. Maxwell–Cattaneo fluids mean that the response of the heat flux with respect to the temperature gradient satisfies a relaxation time law rather than the classical Fourier one. The Chebyshev collocation method is used to resolve the linearized forms of perturbation equations, leading to the formulation of stability eigenvalue problem. By numerically solving the eigenvalue problem, the neutral stability curves in the a–Gr plane for the different values of solute Rayleigh number RaS are obtained. Results show that increasing the double diffusion effect and Louis number Le can suppress the convective instability. Furthermore, compared with Fourier fluid, the Maxwell–Cattaneo fluids in a vertical slot cause an oscillation on the neutral stability curve. The appearance of Maxwell–Cattaneo effect enhances the convection instability. Meanwhile, it is interesting to find that the Maxwell–Cattaneo effect for convective instability becomes stronger as the Prandtl number rises. That means Prandtl number (Pr) also has a significant effect on convective instability. Moreover, the occurrence of two minima on the neutral curve can be found when Pr reaches 12.
Mechanically sustainable and primary recycled thermo-responsive ABS–PLA polymer composites for 4D printing applications: Fabrication and studies
Authors: Thakur Vishal , Singh Rupinder , Kumar Ranvijay , Sharma Shubham , Singh Sunpreet , Li Changhe , Zhang Yanbin , Eldin Sayed M. , Alqarni Sondos Abdullah 
Published: July 2024

Abstract
3D printing is one of the plastic recycling processes that deliver a mechanically sustainable product and may be used for 4D printing applications, such as self-assembly, sensors, actuators, and other engineering applications. The success and implementation of 4D printing are dependent on the tendency of the shape memory with the action of external stimuli, such as heat, force, fields, light, and pH. Acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA) are the most common materials for fused filament fabrication-based 3D printing processes. However, the low-shaped memory tendency on heating and weaker and less rigidity of ABS limit the application domains. PLA is an excellent responsive behavior when the action of heat has high stiffness. The incorporation of PLA into ABS is one of the solutions to tune the shape memory effect for better applicability in the 4D printing domain. In this study, the primary recycled PLA was incorporated into the primary recycled ABS matrix from 5 to 40% (weight%), and composites were made by extrusion in the form of cylindrical filaments for 4D printing. The tensile and shape memory properties of the recycled ABS–PLA composites were investigated to select the best combination. The results of the study were supported by fracture analysis by shape memory analysis, scanning electron microscopy, and optical microscopy. This study revealed that the prepared ABS–PLA-based composites have the potential to be applied in self-assembly applications.