bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical simulation of intermediate‐temperature disk type seal‐less SOFC fed with partially reformed methane
Authors: Tanaka Tadashi , Inui Yoshitaka , Chitose Norihisa 
Published: October 2013

AbstractSince natural gas containing methane as major component is the most promising fuel for the solid oxide fuel cell (SOFC), development of a numerical simulation code of the intermediate‐temperature disk‐type seal‐less SOFC for methane fuel case is considered to be very useful. In this study, therefore, we develop a new simulation code for the single cell unit of this type of SOFC fed with partially reformed methane as the fuel gas, based on the existing simulation code for pure hydrogen. We calculate the current density versus single cell voltage (i–V ) curves of the single cell unit for various cases with a wide range of the cell temperature and prereformer temperature conditions and compare them with the corresponding experimental results. From the results, we confirm that the numerically obtained i–V curves coincide very well with the corresponding experimental ones in all cases. The variations of the i–V curves, which depend not only on the cell temperature but also on the prereformer temperature, are successfully simulated with a sufficiently high accuracy, indicating the validity of the newly developed simulation code. We also investigate the detailed influence of the cell temperature and prereformer temperature on the cell performance on the basis of the numerically obtained gaseous partial pressure profiles in the fuel channel and Nernst potential profiles in the cell, and clarify the reason why the prereformer temperature has obvious influence on the cell performance when the cell temperature is low, though the cell performance is almost independent of the prereformer temperature when the cell temperature is high. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
DC‐balanced perfect classified channel for hiding framing signals
Authors: Sawada Junichi , Nishi Hiroaki 
Published: October 2013

AbstractPerfect classified channel (PCC) was proposed as a hardware‐based Layer‐1 encryption system that prevents of leakage of packet information and any indication of the existence of packets. PCC can provide high‐throughput communication, which is encrypted using AES encryption hardware, while maintaining DC balancing, which is generally managed using the 8B/10B or 64B/66B coding algorithms. In this paper, we propose two methods to classify a framing signal that indicates a boundary between packets, for PCC. These methods facilitate an improved level of security compared with existing communication channels and make PCC more secure. This paper describes the details of the PCC architecture including the hardware costs while also verifying the DC‐balance performance of PCC and the confidentiality of framing signals. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
A hybrid approach for word emotion recognition
Authors: Li Ji , Ren Fuji 
Published: October 2013

AbstractIn recent years, with plenty of online resources constantly emerging, emotion recognition in text has become increasingly important in human–computer interaction. Word emotion plays a very important role in emotion analysis of sentences or documents. This paper proposes a hybrid approach to recognition of word emotion in the dimension of eight emotion categories with corresponding intensities based on the Chinese emotion corpus. First, we present a new algorithm of semantic similarity computation for aiding emotion intensity computation and design a new algorithm of emotion vector computation by making use of both morpheme characteristics and semantic relations. And then, we adopt support vector machine model for the secondary classification to the words whose emotions cannot be calculated by the semantic analysis algorithm. Our approach achieves the accuracy of 54.00% and 78.75% for exact match and all five types of hit, respectively, on the basis of the core emotion lexicon CL4. Experimental results show that the integration of morpheme characteristics and semantic relations can improve the classification accuracy efficiently. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
HER2 Expression in Carcinomas of the True Cardia (Siewert Type II Esophagogastric Junction Carcinoma)
Authors: Katai Hitoshi , Ishida Michihiro , Yamashita Hiroharu , Ohashi Masaki , Morita Shinji , Katayama Hiroshi , Fukagawa Takeo , Kushima Ryoji 
Published: October 2013

AbstractObjectivesTo evaluate the HER2 status in patients with Siewert type II esophagogastric junction carcinoma.Background
Trastuzumab is now approved for use in the treatment of human epidermal growth factor receptor 2 (HER2)‐positive unresectable metastatic gastric or esophagogastric junction (EGJ) carcinoma. Several studies have evaluated HER2 status in EGJ carcinoma, but none has addressed the implication of HER2 positivity in patients with Siewert type II EGJ carcinoma.MethodsWe retrospectively evaluated the frequency of HER2 positivity in a large single‐center cohort of 208 patients with Siewert type II tumors. The relations between HER2 expression and the outcomes and other clinicopathologic features were examined.ResultsOverall, 18.2 % (38/208) of patients in our cohort had HER2‐positive tumors. HER2 positivity was associated only with differentiated carcinomas. The 5‐year overall survival (OS) rate was 58.7 %. The 5‐year OS rates in the patient groups with HER2‐negative and HER2‐positive tumors were 61.2 and 48.5 %, respectively. There was no significant difference between the groups. Recurrence in the liver was observed in 23.7 % patients of the HER2‐positive group and 7.6 % patients of the HER2‐negative group. Multivariate analysis to identify the risk factors for liver recurrence revealed only HER2 positivity (p = 0.0155) as an independent predictive factor.ConclusionsHER2 positivity is a powerful predictor of liver recurrence in patients with Siewert type II EGJ carcinoma. Use of trastuzumab in combination with chemotherapy in an adjuvant setting can be a potentially useful therapeutic strategy to prevent hepatic recurrence in patients with resectable EGJ adenocarcinoma showing HER2 overexpression.
Homotopy invariance of non-stable K1-functors
Authors: Stavrova A. 
Published: October 2013

AbstractLet G be a reductive algebraic group over a field k, such that every semisimple normal subgroup of G has isotropic rank ≥ 2, i.e. contains (Gm)2. Let K1G be the non-stable K1-functor associated to G, also called the Whitehead group of G. We show that K1G(k) = K1G (k[X1 ,…, Xn]) for any n ≥ 1. If k is perfect, this implies that K1G (R) = K1G (R[X]) for any regular k-algebra R. If k is infinite perfect, one also deduces that K1G (R) → K1G (K) is injective for any local regular k-algebra R with the fraction field K.
Partisan brand name building and deficit politics: examining the role of power sharing on party issue consistency
Authors: Lynch Michael S. , Madonna Anthony J. 
Published: October 2013

AbstractScholars of political parties frequently note that a party's candidates are aided by the presence of a consistent and favourable party brand name. We argue that partisan success in maintaining a consistent position on important policy issues hinges on how their role in the government motivates their strategies about public policy formation. Specifically, when parties share control of government institutions, parties need to balance their electoral interest in promoting a consistent brand name with the need to generate public policy that leads to effective governance. When control is held by one party, the costs and benefits of effective governance are born entirely by the majority, absolving both parties of the need to compromise on the substance of policy. By employing item response theory methods to assess patterns of party voting on deficit issues, we find strong support for these hypotheses.
When and how can advocacy groups promote new technologies? Conditions and strategies for effectiveness
Authors: Kim Sung Eun , Urpelainen Johannes 
Published: October 2013

AbstractWhen and how can advocacy groups influence the diffusion of new technologies, such as wind power? We examine the relationship between two different strategies that advocacy groups can adopt: political lobbying and campaigns aimed at potential end users of the new technology. Our game-theoretic analysis shows that without the opportunity to engage in political lobbying, end user campaigns by an advocacy group have the counterproductive effect of reducing the government's incentive to subsidise the new technology. Instead of supporting the advocacy group's campaigning, the government free rides on the social movement's campaigning efforts. While political lobbying cannot prevent free riding, it increases the government's incentive to subsidise the new technology, and thus increases the advocacy group's payoff. These findings suggest that advocacy groups can promote technology diffusion if they can effectively deploy a dual strategy of political lobbying and end user campaigning.
Inheriting the Avant-Garde: Merce Cunningham, Marcel Duchamp, and the “Legacy Plan”
Authors: Noland Carrie 
Published: October 2013

“Repetition is a necessary and justified conduct only in relation to that which cannot be replaced.” —Gilles Deleuze, Difference and Repetition
How does one create a dance legacy? Or, in the case of Merce Cunningham, how does one create an avant-garde dance legacy? Can a corpus of controversial works and ideas be preserved for posterity without betraying the fundamental impulse of an intentionally self-exceeding experimental art? What can be preserved, archived, and bequeathed of a choreographer's work if that choreographer's project was precisely to generate what he had not done before?
X-ray powder diffraction data for norethindrone
Authors: Tang Pei Xiao , Wu Xiao Qing , Zhang Li Li , Cheng Qiang , Li Hui 
Published: October 2013

Experimental X-ray powder diffraction data, unit-cell parameters, and space group for norethindrone, C20H26O2, are reported [a = 20.7484(12) Å, b = 12.1678(9) Å, c = 6.5561(2) Å, α = β = γ = 90°, unit-cell volume V = 1655.17(16) Å3, Z = 4 and space group P212121]. All measured lines were indexed and are consistent with the P212121 space group. No detectable impurity was observed.
Increased incidence of Campylobacter jejuni-associated Guillain–Barré syndromes in the Greater Paris area
Authors: SIVADON-TARDY V. , PORCHER R. , ORLIKOWSKI D. , RONCO E. , GAULT E. , ROUSSI J. , DURAND M.-C. , SHARSHAR T. , ANNANE D. , RAPHAEL J.-C. , MEGRAUD F. , GAILLARD J.-L. 
Published: October 2013

SUMMARYThe role of Campylobacter jejuni as the triggering agent of Guillain–Barré syndrome (GBS) has not been reassessed since the end of the 1990s in France. We report that the number of C. jejuni-related GBS cases increased continuously between 1996 and 2007 in the Paris region (mean annual increment: 7%, P = 0·007).
Diagnosis of congenital heart disease in an era of universal prenatal ultrasound screening in southwest Ohio
Authors: Sekar Priya , Heydarian Haleh C. , Cnota James F. , Hornberger Lisa K. , Michelfelder Erik C. 
Published: October 2013

AbstractObjectivesDiagnostic ultrasound is widespread in obstetric practice, yet many babies with major congenital heart disease remain undiagnosed. Factors affecting prenatal diagnosis of major congenital heart disease are not well understood. This study aims to document prenatal detection rates for major congenital heart disease in the Greater Cincinnati area, and identify factors associated with lack of prenatal diagnosis.MethodsAll living infants diagnosed with major congenital heart disease by 4 months of age at our centre were prospectively identified. Prenatal care data were obtained by parent interview. Neonatal records were reviewed for postnatal data. Obstetricians were contacted for diagnostic ultrasound data.ResultsA total of 100 infants met the inclusion criteria. In all, 95 infants were analysed, of whom 94 were offered diagnostic ultrasound. In all, 41 had a prenatal diagnosis of major congenital heart disease. The rate of prenatal detection varied by cardiac lesion, with aortic arch abnormalities, semilunar valve abnormalities, and venous anomalies going undetected in this sample. Among subjects without prenatal detection, the highest proportion consisted of those having Level 1 diagnostic ultrasound only (66%). Prenatal detection was not significantly influenced by maternal race, education level, income, or insurance type.ConclusionsDespite nearly universal diagnostic ultrasound, detection rates of major congenital heart disease remain low in southwest Ohio. An educational outreach programme including outflow tract sweeps for community-level obstetrical personnel may improve detection rates.
Vegetable variety: an effective strategy to increase vegetable choice in children
Authors: Bucher Tamara , Siegrist Michael , van der Horst Klazine 
Published: October 2013

AbstractObjectiveMost children do not meet the recommended intake of vegetables. Variety was identified as a potential factor to increase children's intake of these foods, as it was shown that variety was effective in improving meal composition in adults. Because younger children are suggested to be more responsive to internal satiation signals than to external food-related cues compared with adults, it is not clear whether variety is effective to improve meal composition in 7- to 10-year-old children.DesignExperiment.SettingChildren were assigned one of three different fake food buffets containing pasta, chicken, and either one vegetable (carrots or beans) or two vegetables (carrots and beans). The children were asked to serve themselves a meal that they would like to eat for lunch from the given selection.SubjectsOne hundred children (fifty-two boys; mean age 8·8 (sd 1·1) years).ResultsChildren given the two-vegetable choice served themselves significantly more energy from vegetables (mean 64 (sd 51) kJ, 10·9 (sd 9·4) %) compared with children who were offered only either carrots (mean 37 (sd 25) kJ, 5·9 (sd 6·5) %) or beans (mean 38 (sd 34) kJ, 5·6 (sd 6·3) %). The total energy of the meal was not increased, indicating that children chose a more balanced lunch when offered more vegetables.ConclusionsSchool-aged children are responsive to food-related cues and variety is effective in increasing their vegetable choice. Serving an assortment of vegetables in school cafeterias might be a simple and effective strategy to improve children's nutrition.
Law, politics, and the true cost of protectionism: the choice of trade remedies or binding overhang
Authors: BUSCH MARC L. , PELC KRZYSZTOF J. 
Published: October 2013

AbstractThe literature on escape clauses in international commerce focuses on the workings of trade remedies. The logic is that, by adhering to a strict methodology that is subject to legal review, trade remedies credibly signal that the government is only temporarily defecting from free trade. And yet, countries often turn, instead, to a measure that does not adhere to a strict methodology and is not subject to legal review: binding overhang, or the gap between a country's bound and applied tariffs. What explains a government's decision to use trade remedies or binding overhang? We argue that trade remedies are used where import surges are big enough that injury can be proven, but low enough that governments have incentive to prove it. Otherwise, binding overhang is their flexibility measure of choice. We conduct a variety of empirical analyses concerning 22 emerging economies with access to both trade remedies and binding overhang. The results strongly bear out our hypothesis, shedding new light on governments' incentives over the design of the law governing flexibility provisions.
Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells
Authors: Wang S , He M-f , Chen Y-h , Wang M-y , Yu X-m , Bai J , Zhu H-y , Wang Y-y , Zhao H , Mei Q , Nie J , Ma J , Wang J-f , Wen Q , Ma L , Wang Y , Wang X-n 
Published: October 2013

AbstractA cell-in-cell process refers to the invasion of one living cell into another homotypic or heterotypic cell. Different from non-apoptotic death processes of internalized cells termed entosis or cannibalism, we previously reported an apoptotic cell-in-cell death occurring during heterotypic cell-in-cell formation. In this study, we further demonstrated that the apoptotic cell-in-cell death occurred only in internalized immune killer cells expressing granzyme B (GzmB). Vacuole wrapping around the internalized cells inside the target cells was the common hallmark during the early stage of all cell-in-cell processes, which resulted in the accumulation of reactive oxygen species and subsequent mitochondrial injury of encapsulated killer or non-cytotoxic immune cells. However, internalized killer cells mediated rapid bubbling of the vacuoles with the subsequent degranulation of GzmB inside the vacuole of the target cells and underwent the reuptake of GzmB by killer cells themselves. The confinement of GzmB inside the vacuole surpassed the lysosome-mediated cell death occurring in heterotypic or homotypic entosis processes, resulting in a GzmB-triggered caspase-dependent apoptotic cell-in-cell death of internalized killer cells. On the contrary, internalized killer cells from GzmB-deficient mice underwent a typical non-apoptotic entotic cell-in-cell death similar to that of non-cytotoxic immune cells or tumor cells. Our results thus demonstrated the critical involvement of immune cells with cytotoxic property in apoptotic cell-in-cell death, which we termed as emperitosis taken from emperipolesis and apoptosis. Whereas entosis or cannibalism may serve as a feed-on mechanism to exacerbate and nourish tumor cells, emperitosis of immune killer cells inside tumor cells may serve as an in-cell danger sensation model to prevent the killing of target cells from inside, implying a unique mechanism for tumor cells to escape from immune surveillance.
Multiplexed biomimetic lipid membranes on graphene by dip-pen nanolithography
Authors: Hirtz Michael , Oikonomou Antonios , Georgiou Thanasis , Fuchs Harald , Vijayaraghavan Aravind 
Published: October 2013

AbstractThe application of graphene in sensor devices depends on the ability to appropriately functionalize the pristine graphene. Here we show the direct writing of tailored phospholipid membranes on graphene using dip-pen nanolithography. Phospholipids exhibit higher mobility on graphene compared with the commonly used silicon dioxide substrate, leading to well-spread uniform membranes. Dip-pen nanolithography allows for multiplexed assembly of phospholipid membranes of different functionalities in close proximity to each other. The membranes are stable in aqueous environments and we observe electronic doping of graphene by charged phospholipids. On the basis of these results, we propose phospholipid membranes as a route for non-covalent immobilization of various functional groups on graphene for applications in biosensing and biocatalysis. As a proof of principle, we demonstrate the specific binding of streptavidin to biotin-functionalized membranes. The combination of atomic force microscopy and binding experiments yields a consistent model for the layer organization within phospholipid stacks on graphene.
A LOV-domain-mediated blue-light-activated adenylate (adenylyl) cyclase from the cyanobacterium Microcoleus chthonoplastes PCC 7420
Authors: Raffelberg Sarah , Wang Linzhu , Gao Shiqiang , Losi Aba , Gärtner Wolfgang , Nagel Georg 
Published: October 2013

Genome screening of the cyanobacterium Microcoleus chthonoplastes PCC 7420 identified a gene encoding a protein (483 amino acids, 54.2 kDa in size) characteristic of a BL (blue light)-regulated adenylate (adenylyl) cyclase function. The photoreceptive part showed signatures of a LOV (light, oxygen, voltage) domain. The gene product, mPAC (Microcoleus photoactivated adenylate cyclase), exhibited the LOV-specific three-peaked absorption band (λmax=450 nm) and underwent conversion into the photoadduct form (λmax=390 nm) upon BL-irradiation. The lifetime for thermal recovery into the parent state was determined as 16 s at 20°C (25 s at 11°C). The adenylate cyclase function showed a constitutive activity (in the dark) that was in-vitro-amplified by a factor of 30 under BL-irradiation. Turnover of the purified protein at saturating light and pH 8 is estimated to 1 cAMP/mPAC per s at 25°C (2 cAMP/mPAC per s at 35°C). The lifetime of light-activated cAMP production after a BL flash was ~14 s at 20°C. The temperature optimum was determined to 35°C and the pH optimum to 8.0. The value for half-maximal activating light intensity is 6 W/m2 (at 35°C). A comparison of mPAC and the BLUF (BL using FAD) protein bPAC (Beggiatoa PAC), as purified proteins and expressed in Xenopus laevis oocytes, yielded higher constitutive activity for mPAC in the dark, but also when illuminated with BL.
A Pair of Tabersonine 16-Hydroxylases Initiates the Synthesis of Vindoline in an Organ-Dependent Manner inCatharanthus roseus
Authors: Besseau Sébastien , Kellner Franziska , Lanoue Arnaud , Thamm Antje M.K. , Salim Vonny , Schneider Bernd , Geu-Flores Fernando , Höfer René , Guirimand Grégory , Guihur Anthony , Oudin Audrey , Glevarec Gaëlle , Foureau Emilien , Papon Nicolas , Clastre Marc , Giglioli-Guivarc’h Nathalie , St-Pierre Benoit , Werck-Reichhart Danièle , Burlat Vincent , De Luca Vincenzo , O’Connor Sarah E. , Courdavault Vincent 
Published: October 2013

AbstractHydroxylation of tabersonine at the C-16 position, catalyzed by tabersonine 16-hydroxylase (T16H), initiates the synthesis of vindoline that constitutes the main alkaloid accumulated in leaves of Catharanthus roseus. Over the last decade, this reaction has been associated with CYP71D12 cloned from undifferentiated C. roseus cells. In this study, we isolated a second cytochrome P450 (CYP71D351) displaying T16H activity. Biochemical characterization demonstrated that CYP71D12 and CYP71D351 both exhibit high affinity for tabersonine and narrow substrate specificity, making of T16H, to our knowledge, the first alkaloid biosynthetic enzyme displaying two isoforms encoded by distinct genes characterized to date in C. roseus. However, both genes dramatically diverge in transcript distribution in planta. While CYP71D12 (T16H1) expression is restricted to flowers and undifferentiated cells, the CYP71D351 (T16H2) expression profile is similar to the other vindoline biosynthetic genes reaching a maximum in young leaves. Moreover, transcript localization by carborundum abrasion and RNA in situ hybridization demonstrated that CYP71D351 messenger RNAs are specifically located to leaf epidermis, which also hosts the next step of vindoline biosynthesis. Comparison of high- and low-vindoline-accumulating C. roseus cultivars also highlights the direct correlation between CYP71D351 transcript and vindoline levels. In addition, CYP71D351 down-regulation mediated by virus-induced gene silencing reduces vindoline accumulation in leaves and redirects the biosynthetic flux toward the production of unmodified alkaloids at the C-16 position. All these data demonstrate that tabersonine 16-hydroxylation is orchestrated in an organ-dependent manner by two genes including CYP71D351, which encodes the specific T16H isoform acting in the foliar vindoline biosynthesis.