bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics
Authors: Molina Angie , Velot Lauriane , Ghouinem Lydia , Abdelkarim Mohamed , Bouchet Benjamin Pierre , Luissint Anny-Claude , Bouhlel Imène , Morel Marina , Sapharikas Elène , Di Tommaso Anne , Honoré Stéphane , Braguer Diane , Gruel Nadège , Vincent-Salomon Anne , Delattre Olivier , Sigal-Zafrani Brigitte , André Fabrice , Terris Benoit , Akhmanova Anna , Di Benedetto Mélanie , Nahmias Clara , Rodrigues-Ferreira Sylvie 
Published: February 2013

Abstract
Metastasis, a fatal complication of breast cancer, does not fully benefit from available therapies. In this study, we investigated whether ATIP3, the major product of 8p22 MTUS1 gene, may be a novel biomarker and therapeutic target for metastatic breast tumors. We show that ATIP3 is a prognostic marker for overall survival among patients with breast cancer. Notably, among metastatic tumors, low ATIP3 levels associate with decreased survival of the patients. By using a well-defined experimental mouse model of cancer metastasis, we show that ATIP3 expression delays the time-course of metastatic progression and limits the number and size of metastases in vivo. In functional studies, ATIP3 silencing increases breast cancer cell migration, whereas ATIP3 expression significantly reduces cell motility and directionality. We report here that ATIP3 is a potent microtubule-stabilizing protein whose depletion increases microtubule dynamics. Our data support the notion that by decreasing microtubule dynamics, ATIP3 controls the ability of microtubule tips to reach the cell cortex during migration, a mechanism that may account for reduced cancer cell motility and metastasis. Of interest, we identify a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration. Our study is a major step toward the development of new personalized treatments against metastatic breast tumors that have lost ATIP3 expression. Cancer Res; 73(9); 2905–15. ©2013 AACR.
Downregulation of HER3 by a Novel Antisense Oligonucleotide, EZN-3920, Improves the Antitumor Activity of EGFR and HER2 Tyrosine Kinase Inhibitors in Animal Models
Authors: Wu Yaming , Zhang Yixian , Wang Maoliang , Li Qi , Qu Zhengxing , Shi Victoria , Kraft Patricia , Kim Steve , Gao Ying , Pak Jenny , Youngster Stephen , Horak Ivan D. , Greenberger Lee M. 
Published: February 2013

AbstractAmong the four human EGF receptor (HER) family members (EGFR, HER2, HER3, HER4), HER3 is of particular interest as it interacts with HER2 and EGFR via heterodimerization and is a key link to the phosphoinositide 3-kinase (PI3K)/AKT signal transduction axis. Recent studies indicate that HER3 plays a critical role in mediating resistance to agents that target EGFR or HER2. As HER3 lacks significant kinase activity and cannot be inhibited by tyrosine kinase inhibitors, neutralizing antibodies and alternative inhibitors of HER3 have been sought as cancer therapeutics. We describe here a locked nucleic acid (LNA)-based HER3 antisense oligonucleotide, EZN-3920, that specifically downmodulated the expression of HER3, which was associated with growth inhibition. EZN-3920 effectively downmodulated HER3 expression, HER3-driven PI3K/AKT signaling pathway, and growth in tumors derived from BT474M1 breast and HCC827 lung carcinoma cell lines, which overexpress HER2 and EGFR, respectively. Furthermore, when EZN-3920 was coadministered with gefitinib or lapatinib in xenograft tumor models, enhanced antitumor activity compared with the effect of monotherapy was found. The effect was associated with a blockade of induced HER3 mRNA expression caused by lapatinib or gefitinib treatment. Finally, EZN-3920 sustained its antiproliferative effect in trastuzumab-resistant cells and three independently derived gefitinib-resistant cells. Our findings show that downmodulation of HER3 by EZN-3920 leads to the suppression of tumor growth in vitro and in vivo, suggesting that HER3 can be an effective target for the treatment of various cancers that have been activated by HER3 alone or where HER3 activation is associated with EGFR or HER2 expression. Mol Cancer Ther; 12(4); 427–37. ©2013 AACR.
Early Evolution and Correlates of Urine Albumin Excretion in Patients Presenting With Acutely Decompensated Heart Failure
Authors: Koyama Satoshi , Sato Yukihito , Tanada Yohei , Fujiwara Hisayoshi , Takatsu Yoshiki 
Published: February 2013

Background—
Urine albumin excretion is an important predictor of adverse cardiovascular events in various populations. Its correlation in patients with acute heart failure has not been described.

Methods and Results—

This prospective, observational study included 115 patients presenting with acute heart failure. The urine albumin/creatinine ratio (UACR) was measured from spot urine samples collected on days 1 and 7 of hospitalization. Median UACR decreased from 83 to 22 mg/gCr on days 1 and 7, respectively (
P
<0.0001). The proportion of patients with normoalbuminuria (UACR <30 mg/gCr) increased from 31% on day 1 to 60% on day 7, whereas the proportion with microalbuminuria (UACR between 30 and 299 mg/gCr) and macroalbuminuria (UACR ≥300 mg/gCr) decreased, respectively, from 42% and 27% on day 1 to 30% and 10% on day 7 (
P
<0.0001). These changes in UACR were correlated with changes in serum bilirubin and N-terminal pro b-type natriuretic peptide concentrations (correlation coefficients 1.087 and 0.384, respectively; 95% confidence interval, 0.394–1.781 and 0.087–0.680, respectively; and
P
=0.003 and 0.013, respectively), although they were not correlated with change in estimated glomerular filtration rate.

Conclusions—
In this sample of patients presenting with acute heart failure, urine albumin excretion was often increased at admission to the hospital and decreased significantly within 7 days of treatment. The decrease was correlated with serum N-terminal pro b-type natriuretic peptide and bilirubin concentrations, although neither with baseline nor with changes in indices of renal function.
Efficacy and Safety of Vorapaxar in Patients With Prior Ischemic Stroke
Authors: Morrow David A. , Alberts Mark J. , Mohr Jay P. , Ameriso Sebastian F. , Bonaca Marc P. , Goto Shinya , Hankey Graeme J. , Murphy Sabina A. , Scirica Benjamin M. , Braunwald Eugene 
Published: February 2013

Background and Purpose—
Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial.

Methods—
We randomly assigned patients with prior atherothrombosis (myocardial infarction, peripheral artery disease, or ischemic stroke) to receive vorapaxar (2.5 mg daily) or placebo added to standard antiplatelet therapy. Patients who qualified with stroke (N=4883) had a history of ischemic stroke in the prior 2 weeks to 12 months. The primary end point was the composite of cardiovascular death, myocardial infarction, or any stroke.

Results—
The qualifying stroke was classified as large vessel in 35%, small vessel in 47%, and other/unknown in 18%. In the stroke cohort, cardiovascular death, myocardial infarction, or stroke through 3 years was not reduced with vorapaxar versus placebo (13.0% vs 11.7%; hazard ratio, 1.03; 95% confidence interval, 0.85–1.25), including recurrent ischemic stroke (hazard ratio, 0.99; 95% confidence interval, 0.78–1.25). There were no significant differences in the effect of vorapaxar based on the type or timing of the qualifying stroke. Intracranial hemorrhage at 3 years was increased with vorapaxar (2.5% vs 1.0%; hazard ratio, 2.52; 95% confidence interval, 1.46–4.36).

Conclusions—
In patients with prior ischemic stroke who receive standard antiplatelet therapy, adding vorapaxar increased the risk of intracranial hemorrhage without an improvement in major vascular events, including ischemic stroke. These findings add to the accumulating evidence establishing important risks with combination antiplatelet therapy in patients with prior stroke.

Clinical Trial Registration Information—

http://www.clinicaltrials.gov
. Unique identifier: NCT00526474.
Prisoners Right to Healthcare, a European Perspective
Authors: Abbing Henriette Roscam 
Published: February 2013

Abstract
The right to healthcare applies regardless of a person’s legal status. Prisoners have a right to a healthcare equivalent to the one in the community at large: access to medical care and preventive measures of good quality and costs covered. States have a positive duty to provide for appropriate healthcare in prison, including harm reduction policies (for instance health screening, vaccination and needle exchange). Denial of access to appropriate health facilities to prisoners and other detainees is likely to result in bodily harm, unnecessary morbidity and avoidable death. Essential elements of the social right to care for the health of prisoners are protected through the positive obligations individual human rights impose on States (e.g., the right to life, the prohibition of torture, degrading treatment and punishment, the right to liberty and the right to private life). Health related human rights standards for prison healthcare have been formulated over worldwide and in Europe. The Council of Europe’s Committee of Prevention of Torture monitors the situation of prisoners in Member States. Still, healthcare for prisoners falls short of what is required. Prison healthcare is an essential part of public health. A major involvement of the Minister of Health is indispensable.
A New Approach to Sex-Based Classifications in the Context of Procreative Rights: S.H. & Others v. Austria in Context
Authors: Sanderson Mike 
Published: February 2013

Abstract
A critical discussion of the recent First Section and Grand Chamber judgments of the European Court of Human Rights in the case of S.H. and Others v. Austria, which upheld an Austrian ban on in-vitro fertilisation (IVF) using donor gametes (ova and sperm). The author argues that the regulatory regime adopted by Austria is overbroad insofar as the regime it adopts fails to accurately reflect the legitimate interests of the state. This is not a conventional “controversial morals” case where, in the absence of a clear moral and/or policy consensus among the Council of Europe member states, states are properly accorded a wide margin of appreciation. The regime adopted by Austria embodies a clear sex bias (with their respective gametes standing as near perfect proxies for the sex of the applicants) with exceptions being made to address male infertility while leaving women without medical remedy. As such, the margin of appreciation should be significantly restricted and the classifications embodied by the regime subject to the highest possible scrutiny.
Risk Assessment vs. Right to Privacy: The Access to Health Information on the Insurance Candidate through Questionnaires and the Right to Privacy
Authors: de Oliveira Martins Maria Inês 
Published: February 2013

Abstract
The need of private insurers for information on the candidate’s health risks is recognized by the law, which places pre-contractual duties of disclosure upon the candidates. When the risks are influenced by health factors, e.g. in the case of life- and health insurances, it implies the provision of health information by the candidates, who thus voluntarily limit their right to privacy. This consent, however, often happens in a context of factual coercion to contract. Next to this, from a legal standpoint, the collection of personal information must respond to the principle of proportionality. Against this background, this article assesses the compatibility of questionnaire techniques that rely on open-ended health related questions with the right to privacy, as protected by Portuguese and international law. It then analyses the extent of pre-contractual duties of disclosure as defined by the Portuguese Insurance Act, which requires the candidate to volunteer all the relevant information independently of being asked for it. In doing so, the article also refers to some other European countries. It concludes that the relevant Portuguese legislation is incompatible both with Portuguese constitutional law and with international law.
Workplace attachment, workspace appropriation, and job satisfaction
Authors: Rioux Liliane , Pignault Anne 
Published: February 2013

The aim of this paper is to clarify the relationship between psycho-environmental variables and work satisfaction by comparing them in a single model of psycho-organizational variables whose impact on satisfaction at work is well known. One hundred and twelve French supermarket workers completed a questionnaire composed of indicators assessing: (a) job satisfaction (ESVP and M.S. Q), (b) psycho-environmental variables (EALT, A-E scale, and a questionnaire about workspace appropriation and workplace attachment), and (c) psycho- organizational variables using some of Karasec's control scales, Geurts' SWING, and Meyer, Allen, and Smith's organizational commitment scale. Regression analysis showed that the psycho-environmental variables were predictors of job satisfaction, some being more relevant predictors of the MSQ and particularly of the ESVP than the psycho-organizational variables. These results contribute to the current debate on the operationalization of the concept of job satisfaction.
An Assessment of a Model-, Grid-, and Basin-Independent Tropical Cyclone Detection Scheme in Selected CMIP3 Global Climate Models
Authors: Tory K. J. , Chand S. S. , Dare R. A. , McBride J. L. 
Published: February 2013

Abstract
A novel tropical cyclone (TC) detection technique designed for coarse-resolution models is tested and evaluated. The detector, based on the Okubo–Weiss–Zeta parameter (OWZP), is applied to a selection of Coupled Model Intercomparison Project, phase 3 (CMIP3), models [Commonwealth Scientific and Industrial Research Organisation Mark, version 3.5 (CSIRO-Mk3.5); Max Planck Institute ECHAM5 (MPI-ECHAM5); and Geophysical Fluid Dynamics Laboratory Climate Model, versions 2.0 (GFDL CM2.0) and 2.1 (GFDL CM2.1)], and the combined performance of the model and detector is assessed by comparison with observed TC climatology for the period 1970–2000. Preliminary TC frequency projections are made using the three better-performing models by comparing the detected TC climatologies between the late twentieth and late twenty-first centuries. Very reasonable TC formation climatologies were detected in CSIRO-Mk3.5, MPI-ECHAM5, and GFDL CM2.1 for most basins, with the exception of the North Atlantic, where a large underdetection was present in all models. The GFDL CM2.0 model was excluded from the projection study because of a systematic underdetection in all basins. The above detection problems have been reported in other published studies, which suggests model rather than detector limitations are mostly responsible. This study demonstrates that coarse-resolution climate models do in general produce TC-like circulations with realistic geographical and seasonal distributions detectable by the OWZP TC detector. The preliminary projection results are consistent with the published literature, based on higher-resolution studies, of a global reduction of TCs between about 6% and 20%, with a much larger spread of results (about +20% to −50%) in individual basins.
Personality disorders in a community sample in Turkey: Prevalence, associated risk factors, temperament and character dimensions
Authors: Dereboy Cigdem , Güzel Halime Senay , Dereboy Ferhan , Okyay Pınar , Eskin Mehmet 
Published: February 2013

Background: Data from Turkey on prevalence of personality disorders (PD) in the normal population are sparse. Aims: The present study conducted in a community sample aimed to investigate personality disorders in terms of prevalence, associated risk factors and personality dimensions. Methods: A stratified sampling procedure allowed us to compose a sample consisting of 774 participants residing in Aydin, Turkey. The DSM-IV and ICD-10 Personality Questionnaire (DIP-Q) and the Temperament and Character Inventory (TCI) were used to assess PDs and personality dimensions, respectively. Results: Roughly 20% of the participants received a PD diagnosis. Among the individual PD categories, schizotypal and obsessive-compulsive PDs were the most prevalent diagnoses. Participants with PD were more likely to have higher self-directedness and cooperativeness scores. These risk factors and personality dimensions were most strongly associated with the cluster B disorders. Conclusion: New versions of the diagnostic systems should include schizotypal, obsessive-compulsive and cluster B PDs as separate diagnostic categories, and impaired self-directedness as well as cooperativeness as a general diagnostic criterion for the sake of backward and forward compatibility of the research in this field.
Section for Residents and Fellows‐in‐Training Survey Results
Authors: Rosenberg Tara L. , Kelley Kanwar , Dowdall Jayme R. , Replogle William H. , Liu Jeffrey C. , Raol Nikhila P. , Zafereo Mark E. 
Published: February 2013

Objectives(1) To present data from the American Academy of Otolaryngology—Head and Neck Surgery (AAO‐HNS) Section for Residents and Fellows‐in‐Training (SRF) annual survey from 2002 to 2011. (2) To compare and analyze trends in resident demographics, residency experiences, and post‐training career choices.Study DesignReview of cross‐sectional survey data.SettingResidents and Fellows registered as Members‐in‐Training through AAO‐HNS.MethodsA review of data from surveys distributed between 2002 and 2011 was conducted. Respondent demographic data including age, postgraduate year, gender, and geographic distribution were analyzed. Responses about training experiences, fellowship selection, debt burden, and post‐training practice choice were studied in order to elicit trends.ResultsRespondents have consistently rated otolaryngology, anesthesia, and trauma/critical care as the most important intern rotations for otolaryngology residents. Each year, approximately 70% of respondents have reported interest in pursuing a fellowship. Pediatric otolaryngology fellowship is now the most popular fellowship among respondents. There has been a recent increase in the percentage of respondents who are interested in pursuing a career in academics. Location, family, and lifestyle have consistently been the most important factors in determining choice of practice. Respondents have reported increasing levels of educational debt.ConclusionThe AAO‐HNS SRF survey collects important data regarding resident/fellow training. Several factors limit the generalizability of these results. Despite its limitations, these unique data provide valuable information for continual evaluation and improvement of physician training in the specialty.
Aggressive Surgical Resection of Anaplastic Thyroid Carcinoma May Provide Long‐term Survival in Selected Patients
Authors: Brown Ryan F. , Ducic Yadranko 
Published: February 2013

ObjectiveIn this study, we present our experience with aggressive surgical treatment in selected patients with anaplastic thyroid cancer with extrathyroidal extension.Study DesignCase series with chart review.SettingTertiary care referral center.Subjects and MethodsRetrospective chart review of all patients with anaplastic thyroid cancer surgically treated by the senior author from January 1998 to July 2012.ResultsA total of 38 cases of anaplastic thyroid cancer were treated (21 male and 17 female). The mean age was 64.5 years. Twenty‐two patients were considered surgically unresectable (18 had distant metastases and 4 had extrathyroidal extension of cancer lateral to carotid arteries) and underwent biopsy with or without tracheostomy. The remaining 16 patients underwent surgical resection with curative intent. Fourteen of these patients underwent postoperative radiation therapy. None of these 16 patients developed local recurrence. Six developed distant metastasis at an average follow‐up of 3.2 months, 1 died of an unrelated myocardial infarction at 3 months, 2 were lost to follow‐up, and 7 remain disease free with an average follow‐up of 4.8 years (range, 9 months to 8 years). Of those patients who underwent complete surgical resection followed by postoperative radiation, 7 of 14 (50%) are still alive, with a mean follow‐up of 4.8 years.ConclusionSelected patients with anaplastic thyroid cancer with extrathyroidal extension (stage IVB) who show no distant metastases by computed tomography or positron emission tomography scans and who do not have tumor extending lateral to the carotid arteries are candidates for complete surgical resection.
A Comparison of Revision Adenoidectomy Rates Based on Techniques
Authors: Sapthavee Andrew , Bhushan Bharat , Penn Edward , Billings Kathleen R. 
Published: February 2013

ObjectiveNo studies are available specifically comparing revision rates between suction coagulator and microdebrider‐performed adenoidectomies. Our objective was to compare revision adenoidectomy rates between these instrument groups.Study DesignHistorical cohort study.SettingPatients included in this study had surgery at the Ann and Robert H. Lurie Children's Hospital in Chicago, Illinois, from June 2007 through December 2011.Subjects and MethodsThe patients were divided into 2 groups based on technique of adenoidectomy used at the time of initial surgery and the regrowth rate analyzed.ResultsDuring the 4.5‐year study period, the microdebrider was used in 4071 adenoidectomies, and 3328 cases were performed with suction coagulation. There was a revision rate of 0.84% (34 patients) for the microdebrider group. The rate was 1.50% (50 patients) for suction coagulation. This difference was found to be statistically significant on univariate analysis. The suction coagulator group had a younger mean age at initial surgery and a higher incidence of gastroesophageal reflux disease. No difference in revision rates between the 2 groups was noted on multivariate analysis.ConclusionSymptomatic regrowth of adenoid tissue occurs infrequently. Both suction coagulation and microdebrider methods are commonly used when performing adenoidectomies due to more consistent ease of use in removal of tissue. The incidence of regrowth likely relates to variables other than the technique used, as there was no difference in the regrowth rate between the 2 groups.