bluuebunny/crossref_metadata_2025_split huggingface dataset:
Job satisfaction and performance among employed Bangladeshi women working from home during COVID‐19 pandemic: A cross‐sectional study
Authors: Jannat Hurul , Saif‐Ur‐Rahman KM , Noor Irfan Nowroze , Begum Afroza 
Published: August 2024

AbstractBackground and AimsThe emergence of the COVID‐19 pandemic led to the adoption of telework modalities by individuals in Bangladesh. The study's objective was to determine the job satisfaction and performance level of employed Bangladeshi women working from home during the COVID‐19 pandemic lockdown.MethodsA cross‐sectional study was conducted among women employees of different professions in Dhaka city. The Minnesota Satisfaction Questionnaire (MSQ) was used to measure job satisfaction. Work arrangement satisfaction and self‐reported performance were measured by two separate subscales which contain five items each. Responses from 118 employed women were analyzed using descriptive statistics, Pearson Chi‐square tests, Independent t‐tests, one‐way analysis of variance, and Pearson Correlation tests through the Statistical Package for Social Science (SPSS), version 26.ResultsThe findings indicated that 51.7% of women reported a high degree of satisfaction on the MSQ scale; 61.9% expressed high satisfaction with their work arrangements at home and 66.9% reported a high level of performance. Job satisfaction was significantly associated with the number of children and the number of family members. A positive association was found between job satisfaction and total working experience and work arrangements. Work performance was strongly associated with higher educational qualifications. A statistically significant association between job satisfaction and performance was revealed.ConclusionsThe findings from this study indicated a high degree of job satisfaction and a high level of performance found in women employees who worked from home during the COVID‐19 pandemic. These findings encourage organizations to foster more policies for telework alternatives for employed women to help them keep a balance between work responsibilities and household chores.
Respiratory system compliance during anesthesia induction and postoperative mechanical ventilation needs: An observational study
Authors: Yamazaki Yukiko , Matsuki Yuka , Hosokawa Koji , Tanaka Katsuya , Kawamura Yuko , Tanaka Aiko , Shigemi Kenji 
Published: August 2024

AbstractBackground and AimsRespiratory system compliance (Crs) is a simple indicator of lung flexibility. However, it remains unclear whether a low Crs during anesthesia induction (iCrs) is associated with an increased risk of postoperative mechanical ventilation.MethodsThis retrospective observational study was conducted using a local database. All mechanically ventilated postoperative ICU patients were included in this study. The duration of postoperative mechanical ventilation, length of hospital stay, and in‐hospital mortality were compared between the low iCrs group (<25% of distribution) and the normal iCrs group.ResultsA total of 315 patients were classified into the low iCrs (<39 mL/cmH2O) group (n = 78) or the normal iCrs group (n = 237). Low iCrs was associated with a higher chance of mechanical ventilation in 28 days (log‐rank test, p < 0.001). The duration of hospital stay was similar. Multivariate analysis showed that in‐hospital mortality was higher in the low iCrs group than in the normal iCrs group (adjusted odds ratio, 6.04 [1.13, 32.26]; p = 0.04).ConclusionLow iCrs was associated with an increased risk of requiring postoperative mechanical ventilation. An additional result of poor survival related to low iCrs may require further study.
The implications of the TNFα‐TNFR2 immune checkpoint signaling pathway in cancer treatment: From immunoregulation to angiogenesis
Authors: Emamalipour Melissa , Shamdani Sara , Mansoori Behzad , Uzan Georges , Naserian Sina 
Published: August 2024

AbstractDespite the tremendous advances that have been made in biomedical research, cancer remains one of the leading causes of death worldwide. Several therapeutic approaches have been suggested and applied to treat cancer with impressive results. Immunotherapy based on targeting immune checkpoint signaling pathways proved to be one of the most efficient. In this review article, we will focus on the recently discovered TNFα‐TNFR2 signaling pathway, which controls the immunological and pro‐angiogenic properties of many immunoregulatory and pro‐angiogenic cells such as endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), and regulatory T cells (Tregs). Due to their biological properties, these cells can play a major role in cancer progression and metastasis. Therefore, we will discuss the advantages and disadvantages of an anti‐TNFR2 treatment that could carry two faces under one hood. It interrupts the immunosuppressive and pro‐angiogenic behaviors of the above‐mentioned cells and interferes with tumor growth and survival.
A multi‐dimensional evaluation system for e‐government development: Based on complex systems theory
Authors: Peng Lifang , Peng Yubo , Wang Suli , Jiang Hui , Li Gang 
Published: August 2024

AbstractGovernments are increasingly placing an emphasis on the long‐term growth of e‐government development. However, the evaluation of e‐government development is still in its infancy. The current research proposes a multi‐dimensional evaluation system of e‐government development based on Complex Systems Theory. Accordingly, we extracted three dimensions with 17 criteria and collected actual data of e‐government development from 17 cities in Shandong, China as an example. The Analytic Hierarchy Process‐Entropy Method (AHP‐EM) was employed to correctly and objectively evaluate the performance of e‐government development. Furthermore, we analyze the current situations and deficiencies of e‐government development in each city of Shandong, China and offer recommendations for sustainable e‐government development using geographical distribution maps and radar graph.
Taurine and enzymatically modified isoquercitrin protected against methotrexate‐induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti‐inflammatory, and histological architecture approach
Authors: Mahmoud Marwa M. , El‐Batran Seham A. , Hegazy Rehab , El‐Sayed Wael M. 
Published: August 2024

AbstractCardiotoxicity is one of the most devastating complications of cancer treatment by methotrexate (MTX). The present study aimed to investigate the potential anti‐cardiotoxic efficacy of taurine (Tau) and enzymatically modified isoquercitrin (EMIQ) alone or combined against MTX‐induced cardiotoxicity in adult male rats. A total of 36 rats were randomly divided into six groups (six animals each): control, MTX (a single i.p. dose of 20 mg/kg), EMIQ + MTX (26 mg/kg of EMIQ, p.o. for 16 days), Tau + MTX (500 mg/kg of Tau, p.o. for 16 days), EMIQ + Tau + MTX at the same previous doses, and (EMIQ + Tau)½ + MTX. MTX reduced the percentage of body weight change, the expression of dihydrofolate reductase (DHFR) and folypolyglutamyl synthetase (FPGS), the cleaved tumor necrosis factor alpha (TNF‐α) level in the cardiac tissue, and the elevated serum TNF‐α level. MTX extensively deteriorated the electrocardiography (ECG), inducing tachycardia with shortening of the time intervals between successive heartbeats (R‐R interval), associated with elongation of ventricular depolarization (QRS interval), and the corrected total time for ventricular de‐ and repolarization (QTc) duration. Treatment with MTX resulted in a significant reduction in atrial depolarization (P amplitude) and rapid repolarization (T amplitude) and a significant elevation in plateau phase (ST height). MTX treatment resulted in swelling of cardiomyocytes with extensive vacuolization of sarcoplasm with numerous variably sized vacuoles in addition to apoptotic cells. Tau and EMIQ protected against MTX‐induced deteriorations in the conductivity and rhythmicity of the heart through antioxidative, anti‐inflammatory, and antiapoptotic activities. Treatment with tau and EMIQ combined at high or low doses offered superior protection to the heart than using each agent alone.
The high electron mobility for spin‐down channel of two‐dimensional spin‐polarized half‐metallic ferromagnetic EuSi2N4 monolayer
Authors: Zhang Bo , Wang Huai‐Qian , Li Hui‐Fang , Zheng Hao , Zhang Yong‐Hang , Mei Xun‐Jie , Zhang Jia‐Ming , Jiang Kai‐Le , Jiang Qing‐Wei 
Published: August 2024

AbstractThe two‐dimensional (2D) monolayer material MoSi2N4 was successfully synthesized in 2020[Hong et al., Science 369, 670, (2020)], exhibiting a plethora of new phenomena and unusual properties, with good stability at room temperature. However, MA2Z4 family monolayer materials involve primarily transition metal substitutions for M atoms. In order to address the research gap on lanthanide and actinide MA2Z4 materials, this work conducts electronic structure calculations on novel 2D MSi2N4 (M = La, Eu) monolayer materials by employing first‐principles methods and CASTEP. High carrier mobility is discovered in the indirect bandgap semiconductor 2D LaSi2N4 monolayer (~5400 cm2 V−1 s−1) and in the spin (spin‐down channel) carrier mobility of the half‐metallic ferromagnetic EuSi2N4 monolayer (~2800 cm2 V−1 s−1). EuSi2N4 monolayer supplements research on spin carrier mobility in half‐metallic ferromagnetic monolayer materials at room temperature and possesses a magnetic moment of 5 μB, which should not be underestimated. Furthermore, due to the unique electronic band structure of EuSi2N4 monolayer (with the spin‐up channel exhibiting metallic properties and the spin‐down channel exhibiting semiconductor properties), it demonstrates a 100% spin polarization rate, presenting significant potential applications in fields such as magnetic storage, magnetic sensing, and spintronics.
The LTAR Integrated Common Experiment at Upper Mississippi River Basin‐Platteville
Authors: Busch Dennis L. , Mahmud Kishan , Johnson Jane M. F. , Papanicolaou Athanasios , Baker John M. , Cartmill Andrew D. 
Published: August 2024

AbstractAlternative agronomic practices are needed to address the various climatic, agronomic, edaphic, and water quality related challenges faced by the dairy farmers of the Driftless Area (DA) in the Upper Mississippi River Basin (UMRB). These practices should be innovative in nature, inclusive of regional stakeholders, and sustainable to meet the future food and climate related challenges of Wisconsin agriculture. Here, we outline our Integrated (grazing and cropland) Long‐Term Agroecosystem Research Common Experiment at the University of Wisconsin‐Platteville Pioneer Farm (UW‐P PF) in the UMRB and describe our collaboration in this USDA network. In this field‐scale experiment, we are comparing the conventional dairy production system common to this region (i.e., corn‐on‐corn [Zea mays L.] for 4 years, followed by alfalfa [Medicago sativa L.] for 3 years, with no cover crops) with two alternative dairy production systems—(1) soil health management with no‐till, cover crops, and application of a novel manure‐based nutrient‐rich stable product, and (2) management intensive grazing—and rotational grazing on pastures established with diverse forage–legume mix. Meteorological, edaphic, hydrologic, and agronomic data are collected and analyzed at regular frequencies. Going forward, the experiment will continue as a form of stakeholder‐driven adaptive research and receive evaluation on a regular basis to determine whether any changes are required to address the “real‐world” challenges faced by the farmers in the Midwest.
Cellular mechanisms of acute rhabdomyolysis in inherited metabolic diseases
Authors: de Calbiac Hortense , Imbard Apolline , de Lonlay Pascale 
Published: August 2024

AbstractAcute rhabdomyolysis (RM) constitutes a life‐threatening emergency resulting from the (acute) breakdown of skeletal myofibers, characterized by a plasma creatine kinase (CK) level exceeding 1000 IU/L in response to a precipitating factor. Genetic predisposition, particularly inherited metabolic diseases, often underlie RM, contributing to recurrent episodes. Both sporadic and congenital forms of RM share common triggers. Considering the skeletal muscle's urgent need to rapidly adjust to environmental cues, sustaining sufficient energy levels and functional autophagy and mitophagy processes are vital for its preservation and response to stressors. Crucially, the composition of membrane lipids, along with lipid and calcium transport, and the availability of adenosine triphosphate (ATP), influence membrane biophysical properties, membrane curvature in skeletal muscle, calcium channel signaling regulation, and determine the characteristics of autophagic organelles. Consequently, a genetic defect involving ATP depletion, aberrant calcium release, abnormal lipid metabolism and/or lipid or calcium transport, and/or impaired anterograde trafficking may disrupt autophagy resulting in RM. The complex composition of lipid membranes also alters Toll‐like receptor signaling and viral replication. In response, infections, recognized triggers of RM, stimulate increased levels of inflammatory cytokines, affecting skeletal muscle integrity, energy metabolism, and cellular trafficking, while elevated temperatures can reduce the activity of thermolabile enzymes. Overall, several mechanisms can account for RMs and may be associated in the same disease‐causing RM.
Checking the inventory: Illustrating different methods for individual participant data meta‐analytic structural equation modeling
Authors: Groot Lennert J. , Kan Kees‐Jan , Jak Suzanne 
Published: August 2024

AbstractResearchers may have at their disposal the raw data of the studies they wish to meta‐analyze. The goal of this study is to identify, illustrate, and compare a range of possible analysis options for researchers to whom raw data are available, wanting to fit a structural equation model (SEM) to these data. This study illustrates techniques that directly analyze the raw data, such as multilevel and multigroup SEM, and techniques based on summary statistics, such as correlation‐based meta‐analytical structural equation modeling (MASEM), discussing differences in procedures, capabilities, and outcomes. This is done by analyzing a previously published collection of datasets using open source software. A path model reflecting the theory of planned behavior is fitted to these datasets using different techniques involving SEM. Apart from differences in handling of missing data, the ability to include study‐level moderators, and conceptualization of heterogeneity, results show differences in parameter estimates and standard errors across methods. Further research is needed to properly formulate guidelines for applied researchers looking to conduct individual participant data MASEM.
Otolaryngic Allergy Patient Journey Mapping: A Framework for Allergy Immunotherapy Adherence
Authors: Melon David E. , Pillsbury Harold C. , Harrill Willard C. 
Published: August 2024

ObjectivesAllergen‐specific immunotherapy (AIT) is an effective treatment for allergic disease but requires long treatment duration and premature cessation is of significant concern. Drivers of premature cessation remain poorly understood and no predictive models currently exist. We hypothesized that a novel patient journey map and de novo real‐time patient electronic health status instruments (eHSIs) could effectively capture patient perceived cost, commitment, and treatment benefit to identify individual patients at risk for premature AIT cessation.Study TypeCross‐Sectional Observational Study.MethodsA single Otolaryngology allergy immunotherapy (AIT) program was studied over 5 years. Instances of premature cessation were classified. An Otolaryngic Allergy Patient Journey Map was developed to identify and target automated, real‐time, patient‐reported, electronic health status instrument responses.ResultsData capture was robust, with 61,406 data points collected and an eHSI survey completion rate of 81.3%. However, based on correlation analysis and logistic regression alone, real‐time eHSI responses were not predictive of individual patient premature AIT cessation. A total of 597 AIT patients discontinued treatment prematurely: 64.4% stopping within the first year. Specifically, 74.0%–76.3% of subcutaneous AIT patients and 88.5%–100% of sublingual AIT patients did not complete the minimum recommended treatment duration of 3 years.ConclusionPatient journey mapping can aid in the design of longitudinal care models and patient engagement strategies. Yet, eHSI patient responses of perception of AIT cost, benefit, and convenience did not correlate with the likelihood of premature treatment cessation. Our imperfect clinical intuition may not account for the dynamic drivers of premature AIT discontinuation. Future development of predictive tools feed by large patient‐centric data sets may be incorporated into routine practice resulting in delivery of a more streamlined and personalized approach with reduced premature AIT cessation, improved outcomes, and reduced health care expenditures.Level of EvidenceNA Laryngoscope, 134:S1–S14, 2024
Olfactory perceptual fingerprints of people with olfactory dysfunction and healthy controls
Authors: Drnovsek Eva , Haehner Antje , Bensafi Moustafa , Hummel Thomas 
Published: August 2024

AbstractObjective(s)An olfactory perceptual fingerprint (OPF) defines one's olfactory perception using perceptual descriptor ratings (such as odor pleasantness, intensity) for a set of odors. OPFs have been shown to distinguish patients with COVID‐related olfactory dysfunction (OD) and healthy controls with 86% accuracy. However, all participants rated the same odorants. With the aim to evaluate whether the OPFs are indeed odorant independent, previously published dataset by Lötsch et al. was reanalyzed. Furthermore, this independent dataset was used to check whether the OPFs separate patients with OD due to various causes from controls.MethodsThe study included 104 controls and 42 patients, who were randomized into four odor sets with 10 odorants each. Odorants were presented using a computer‐controlled olfactometer and evaluated on scales from 1 (not at all) to 5 (very) using perceptual descriptors pleasant, intensive, familiar, edible, irritating, cold/warm, and painful.ResultsPermutational multivariate analysis of variance showed that the odor set did not have a significant effect on the OPFs, confirming that the OPFs are indeed odorant independent. On the other hand, both diagnosis and age affected the OPFs (p < .001) and explained around 11% and 5% of the variance of the OPFs, respectively. Furthermore, a supervised machine learning method, random forest classifier, showed that OPF can distinguish patients and controls with 80% accuracy.ConclusionOPFs are odorant independent. Patients perceived odors as less familiar, less intense, and less edible than controls. Other perceptual descriptors were much less important for the separation of patients and controls.Level of evidence3
Temporal distance in dual sourcing: A behavioural investigation
Authors: Balaguer‐Mercado Alain , Kirshner Samuel N. , Tseng Chung‐Li 
Published: August 2024

AbstractWe explored the influence of temporal distances on order allocation between a low‐cost, less reliable supplier and a reliable, high‐cost supplier. We posited that a far temporal distance increases the preference for the unreliable, low‐cost supplier. We conducted a vignette‐based experiment where participants placed orders between the suppliers with different reliability and cost levels. Our experiment showed that a longer lead time led to larger orders for the low‐cost unreliable supplier. Our insights help explain how temporal distances inherent in supply chains can elicit differing evaluations of suppliers, altering ordering decisions.
Tissue Doppler ultrasound of arm muscles to assess myotonia in myotonic dystrophies: An exploratory study
Authors: Svačina Martin K. R. , Sprenger‐Svačina Alina , Kohle Felix , Wunderlich Gilbert , Lehmann Helmar C. , Schneider Christian 
Published: August 2024

AbstractIntroduction/AimsMyotonia is a key symptom of myotonic dystrophies (DM), and its quantification is challenging. This exploratory study evaluated the utility of tissue Doppler ultrasound (TDU) to assess myotonia in DM.MethodsTwelve DM patients (seven type‐1 DM [DM1] and five type‐2 DM [DM2]) and 20 age‐matched healthy subjects were included in this cross‐sectional study. After measuring cross‐sectional areas of the flexor digitorum superficialis (FDS) and extensor digitorum communis (EDC) muscles in a resting state, muscle contraction/relaxation time, time to peak tissue velocity, peak tissue velocity and velocity gradients of these muscles were measured via TDU while performing forced fist unclenching after fist closure. Additionally, grip strength, Medical Research Council Sum score and patient‐reported myotonia severity scores were assessed.ResultsDM1 and DM2 patients had a lower grip strength than healthy subjects (p = .0001/p = .002). Patient‐reported myotonia did not differ between DM1 and DM2 patients. DM1 patients revealed FDS and EDC atrophy compared to DM2 patients and healthy subjects (p = .003/p = .004). TDU revealed prolonged muscle contraction and relaxation times in both DM subtypes, with prolonged time to reach FDS peak relaxation velocity and altered peak FDS relaxation velocity only in DM1 patients (p = .03/p = .003). Peak FDS relaxation velocity correlated inversely with C(C)TG repeat numbers in DM patients. Sensitivity of TDU parameters to detect myotonic dystrophy varied between 50% and 75%, with a specificity of 95%.DiscussionOur exploratory study suggests that TDU could serve as a novel tool to quantify myotonia in DM patients, but larger follow‐up studies are warranted to validate its diagnostic accuracy.
Outcome measures used in peripheral nerve surgery for symptomatic neuroma in upper extremity amputations: A scoping review
Authors: Yang Borum , Suresh Rachana , Nam Jon , Mayo Amanda L. , Hitzig Sander L. , Wong Alison 
Published: August 2024

AbstractNovel surgical treatments for painful neuromas are increasingly used, but determining which provides the greatest benefit has been difficult due to the inconsistent use of outcome measures. We mapped the current literature of outcome measures used to evaluate peripheral nerve surgery for the management of symptomatic neuromas in patients who underwent an adult‐acquired upper extremity amputation (UEA). Medline, Embase, Cochrane, and CINAHL were searched for primary research written in the English language from inception to February 2023. The search yielded 1137 articles, of which 35 were included for final analysis. Studies varied in their assessment of pain, health‐related quality of life (HRQOL), neurotrophic measures, psychological and sensorimotor function, highlighting a consensus on crucial domains but also revealing significant heterogeneity in the use and application of outcome measures among primary studies. Our findings highlight the need to establish common standards that reflect the best evidence and unique needs of the UEA population. This includes developing a core outcome set, utilizing multi‐center trials, and maintaining flexibility to adapt to ongoing advancements in patient‐reported outcome measures (PROMs) research.