bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unrecognised myocardial infarction in patients with schizophrenia
Authors: Nielsen Jimmi , Juel Jacob , Al Zuhairi Karam Sadoon Majeed , Friis Rasmus , Graff Claus , Kanters Jørgen Kim , Jensen Svend Eggert 
Published: January 2015

ObjectiveSchizophrenia is associated with a reduction of the lifespan by 20 years, with type II diabetes and cardiovascular disease contributing the most to the increased mortality. Unrecognised or silent myocardial infarction (MI) occurs in ~30% of the population, but the rates of unrecognised MI in patients with schizophrenia have only been sparsely investigated.MethodElectrocardiograms (ECG) from three psychiatric hospitals in Denmark were manually interpreted for signs of previous MI. Subsequently, ECGs were linked to the National Patient Registry in order to determine whether patients had a diagnosis consistent with previous MI.ResultsA total of 937 ECGs were interpreted, 538 men (57.4%) and 399 women (42.6%). Mean age at the time of ECG acquisition was 40.6 years (95% CI: 39.7–41.5, range: 15.9–94.6). We identified 32 patients with positive ECG signs of MIs. Only two of these patients had a diagnosis of MI in the National Patient Registry. An additional number of eight patients had a diagnosis of MI in the Danish National Patient Registry, but with no ECG signs of previous MI. This means that 30 out of 40 (75%) MIs were unrecognised. Only increasing age was associated with unrecognised MI in a stepwise multiple logistic regression model compared with patients with no history of MI, OR: 1.03 per year of age, 95% CI: 1.00–1.06, p=0.021.ConclusionUnrecognised MI is common among patients with schizophrenia and may contribute to the increased mortality found in this patient group.
Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread
Authors: Keaveney Edel M. , Price Ruth K. , Hamill Lesley L. , Wallace Julie M. W. , McNulty Helene , Ward Mary , Strain J. J. , Ueland Per M. , Molloy Anne M. , Piironen Vieno , von Reding Walter , Shewry Peter R. , Ward Jane L. , Welch Robert W. 
Published: January 2015

The bran and particularly the aleurone fraction of wheat are high in betaine and other physiological methyl donors, which may exert beneficial physiological effects. We conducted two randomised, controlled, cross-over postprandial studies to assess and compare plasma betaine and other methyl donor-related responses following the consumption of minimally processed bran and aleurone fractions (study A) and aleurone bread (study B). For both studies, standard pharmacokinetic parameters were derived for betaine, choline, folate, dimethylglycine (DMG), total homocysteine and methionine from plasma samples taken at 0, 0·5, 1, 2 and 3 h. In study A (n14), plasma betaine concentrations were significantly and substantially elevated from 0·5 to 3 h following the consumption of both bran and aleurone compared with the control; however, aleurone gave significantly higher responses than bran. Small, but significant, increases were also observed in DMG measures; however, no significant responses were observed in other analytes. In study B (n13), plasma betaine concentrations were significantly and substantially higher following consumption of the aleurone bread compared with the control bread; small, but significant, increases were also observed in DMG and folate measures in response to consumption of the aleurone bread; however, no significant responses were observed in other analytes. Peak plasma betaine concentrations, which were 1·7–1·8 times the baseline levels, were attained earlier following the consumption of minimally processed aleurone compared with the aleurone bread (time taken to reach peak concentration 1·2v.2·1 h). These results showed that the consumption of minimally processed wheat bran, and particularly the aleurone fraction, yielded substantial postprandial increases in plasma betaine concentrations. Furthermore, these effects appear to be maintained when aleurone was incorporated into bread.
Longevity-contingent deferred life annuities
Authors: DENUIT M. , HABERMAN S. , RENSHAW A. E. 
Published: January 2015

AbstractConsidering the substantial systematic longevity risk threatening annuity providers’ solvency, indexing benefits on actual mortality improvements appears to be an efficient risk management tool, as discussed in Denuitet al. (2011) and Richter and Weber (2011). Whereas these papers consider indexing annuity payments, the present work suggests that the length of the deferment period could also be subject to revision, providing longevity-contingent deferred life annuities.
Coherent coupling of molecular resonators with a microcavity mode
Authors: Shalabney A. , George J. , Hutchison J. , Pupillo G. , Genet C. , Ebbesen T. W. 
Published: January 2015

AbstractThe optical hybridization of the electronic states in strongly coupled molecule–cavity systems have revealed unique properties, such as lasing, room temperature polariton condensation and the modification of excited electronic landscapes involved in molecular isomerization. Here we show that molecular vibrational modes of the electronic ground state can also be coherently coupled with a microcavity mode at room temperature, given the low vibrational thermal occupation factors associated with molecular vibrations, and the collective coupling of a large ensemble of molecules immersed within the cavity-mode volume. This enables the enhancement of the collective Rabi-exchange rate with respect to the single-oscillator coupling strength. The possibility of inducing large shifts in the vibrational frequency of selected molecular bonds should have immediate consequences for chemistry.
Interfacial charge-mediated non-volatile magnetoelectric coupling in Co0.3Fe0.7/Ba0.6Sr0.4TiO3/Nb:SrTiO3 multiferroic heterostructures
Authors: Zhou Ziyao , Howe Brandon M. , Liu Ming , Nan Tianxiang , Chen Xing , Mahalingam Krishnamurthy , Sun Nian X. , Brown Gail J. 
Published: January 2015

AbstractThe central challenge in realizing non-volatile, E-field manipulation of magnetism lies in finding an energy efficient means to switch between the distinct magnetic states in a stable and reversible manner. In this work, we demonstrate using electrical polarization-induced charge screening to change the ground state of magnetic ordering in order to non-volatilely tune magnetic properties in ultra-thin Co0.3Fe0.7/Ba0.6Sr0.4TiO3/Nb:SrTiO3 (001) multiferroic heterostructures. A robust, voltage-induced, non-volatile manipulation of out-of-plane magnetic anisotropy up to 40 Oe is demonstrated and confirmed by ferromagnetic resonance measurements. This discovery provides a framework for realizing charge-sensitive order parameter tuning in ultra-thin multiferroic heterostructures, demonstrating great potential for delivering compact, lightweight, reconfigurable and energy-efficient electronic devices.
No DNA damage response and negligible genome-wide transcriptional changes in human embryonic stem cells exposed to terahertz radiation
Authors: Bogomazova A. N. , Vassina E. M. , Goryachkovskaya T. N. , Popik V. M. , Sokolov A. S. , Kolchanov N. A. , Lagarkova M. A. , Kiselev S. L. , Peltek S. E. 
Published: January 2015

AbstractTerahertz (THz) radiation was proposed recently for use in various applications, including medical imaging and security scanners. However, there are concerns regarding the possible biological effects of non-ionising electromagnetic radiation in the THz range on cells. Human embryonic stem cells (hESCs) are extremely sensitive to environmental stimuli and we therefore utilised this cell model to investigate the non-thermal effects of THz irradiation. We studied DNA damage and transcriptome responses in hESCs exposed to narrow-band THz radiation (2.3 THz) under strict temperature control. The transcription of approximately 1% of genes was subtly increased following THz irradiation. Functional annotation enrichment analysis of differentially expressed genes revealed 15 functional classes, which were mostly related to mitochondria. Terahertz irradiation did not induce the formation of γH2AX foci or structural chromosomal aberrations in hESCs. We did not observe any effect on the mitotic index or morphology of the hESCs following THz exposure.
Low profile dual‐band antenna loaded with artificial magnetic conductor for indoor radar systems
Authors: Yan Sen , Soh Ping Jack , Mercuri Marco , Schreurs Dominique M.M.‐P. , Vandenbosch Guy A.E. 
Published: January 2015

A dual‐band antenna is designed for a fall‐detection radar and telemetry system. The radar is designed based on the stepped frequency continuous wave (SFCW) concept, which requires Ultra Wideband (UWB) operation, low inter‐element coupling and a directive radiation pattern with low backlobe. The telemetry system uses the 2.45 GHz band to enable signal transmission/reception in an indoor environment and the 6–7.5 GHz band for radar sensing part. A main dual‐band radiator with a slotted patch is used as the basis for the antenna design: the patch resonates at 2.45 GHz whereas the antenna slot enables a wide band operation for the radar system. To enable a low‐profile, an artificial magnetic conductor (AMC) structure is integrated into the antenna. It works as a perfect magnetic conductor (PMC) plane from 6 to 7.5 GHz and can be located close to the slot antenna functioning as a reflector. Both numerical and experimental results indicate a satisfactory antenna performance in terms of reflection coefficient and radiation pattern. The antenna was also integrated into the radar system and tested in a real environment on three subjects at fixed distances. A fall‐detection up to 6 meters was achieved.
Nonprice incentives and energy conservation
Authors: Asensio Omar I. , Delmas Magali A. 
Published: January 2015

Significance
We investigate the effectiveness of nonprice incentives to motivate conservation behavior. We test whether tailored information about environmental and health damages produces behavior change in the residential electricity sector. In a randomized controlled trial with real-time appliance-level energy metering over 8 mo, we find that environment and health-based information strategies outperform monetary savings information to drive energy conservation. Environment and health-based messages, which communicate the environmental and public health externalities of electricity production—such as pounds of pollutants, childhood asthma, and cancer—motivated 8% energy savings versus control. This strategy was particularly effective on families with children, who achieved 19% energy savings. However, we do not study the persistence of these behavioral changes after the conclusion of the study.
Timely sleep facilitates declarative memory consolidation in infants
Authors: Seehagen Sabine , Konrad Carolin , Herbert Jane S. , Schneider Silvia 
Published: January 2015

Significance
The potential benefits of infant sleep for memory processing are largely unexplored. Here we show evidence that having an extended nap (≥30 min) within 4 h of learning helps 6- and 12-month-old infants to retain their memories for new behaviors across a 4- and 24-h delay. These results suggest that infants rely on frequent naps for the formation of long-term memories.
The effects of bilingualism on the white matter structure of the brain
Authors: Pliatsikas Christos , Moschopoulou Elisavet , Saddy James Douglas 
Published: January 2015

Significance
This article fills an important gap in the literature on structural changes in the brain that are induced by speaking two languages. It has been suggested that early lifelong bilingualism affects the structure of white matter (WM) of the brain and preserves its integrity in older age. Here we show that similar WM effects are also found in bilingual individuals who learn their second language (L2) later in life and are active users of both languages. This finding presents a strong argument for the general benefits of additional language learning and the importance of language learning and use in a naturalistic environment.
Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes
Authors: Gibbons John G. , Branco Alan T. , Godinho Susana A. , Yu Shoukai , Lemos Bernardo 
Published: January 2015

Significance
Ribosomes are essential intracellular machines composed of proteins and RNA molecules. The DNA sequences [i.e., ribosomal DNA (rDNA)] encoding rRNAs are tandemly repeated and give rise to the nucleolus. The rRNAs are transcribed from two array kinds (the 5S and the 45S arrays). Here we show that variation in the 5S and 45S rDNA arrays is tightly coupled, despite their location on different chromosomes. Our observations suggest that natural selection contributes to maintain balanced rDNA dosage across unlinked rDNA arrays. Finally, we show that bisphenol A can induce parallel loss of rDNA units in 5S and 45S arrays. These observations raise the prospect that human diseases might be traced to disrupted rDNA dosage balance in the genome.
Translation initiation mediated by RNA looping
Authors: Paek Ki Young , Hong Ka Young , Ryu Incheol , Park Sung Mi , Keum Sun Ju , Kwon Oh Sung , Jang Sung Key 
Published: January 2015

Significance
“Ribosomal scanning” is the generally accepted hypothesis for explaining how eukaryotic 40S ribosomal subunits find initiation codons. Some recently described phenomena cannot be explained by the ribosomal scanning hypothesis, however. Here we show that 43S ribosomal complexes recruited to locations downstream of a reporter gene can direct translation of the reporter independent of the 5′ end, suggesting that 43S ribosomal complex recognizes the initiation codon by “RNA looping” of the intervening mRNA segment between the ribosome recruiting site and the initiation codon. Moreover, we provide a mathematical model for the RNA looping hypothesis. The RNA looping hypothesis provides a logical explanation for translational augmentation by translation-enhancing elements located upstream and/or downstream of a protein-coding region.
STEP61is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease
Authors: Kurup Pradeep K. , Xu Jian , Videira Rita Alexandra , Ononenyi Chimezie , Baltazar Graça , Lombroso Paul J. , Nairn Angus C. 
Published: January 2015

SignificanceIn neurons, STEP61(striatal-enriched protein tyrosine phosphatase) protein levels are tightly regulated, and the protein’s up-regulation is implicated in several neuropsychiatric disorders. Here, we demonstrate that parkin is a major E3 ligase regulating STEP61levels through the ubiquitin proteasome system. In Parkinson’s disease, in which parkin function is compromised, STEP61levels increase, which is associated with down-regulation of synaptic proteins required for neuronal plasticity.
Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish
Authors: Kinch Cassandra D. , Ibhazehiebo Kingsley , Jeong Joo-Hyun , Habibi Hamid R. , Kurrasch Deborah M. 
Published: January 2015

Significance
Here we demonstrate that bisphenol A (BPA) exposure during a time point analogous to the second trimester in humans has real and measurable effects on brain development and behavior. Furthermore, our study is the first, to our knowledge, to show that bisphenol S, a replacement used in BPA-free products, equally affects neurodevelopment. These findings suggest that BPA-free products are not necessarily safe and support a societal push to remove all structurally similar bisphenol analogues and other compounds with endocrine-disruptive activity from consumer goods. Our data here, combined with over a dozen physiological and behavioral human studies that begin to point to the prenatal period as a BPA window of vulnerability, suggest that pregnant mothers limit exposure to plastics and receipts.
Colorimetric Method of Loop-Mediated Isothermal Amplification with the Pre-Addition of Calcein for Detecting Flavobacterium columnare and its Assessment in Tilapia Farms
Authors: Suebsing Rungkarn , Kampeera Jantana , Sirithammajak Sarawut , Withyachumnarnkul Boonsirm , Turner Warren , Kiatpathomchai Wansika 
Published: January 2015

Abstract
Flavobacterium columnare, the causative agent of columnaris disease in fish, affects many economically important freshwater fish species. A colorimetric method of loop-mediated isothermal amplification with the pre-addition of calcein (LAMP–calcein) was developed and used to detect the presence of F. columnare in farmed tilapia (Nile Tilapia Oreochromis niloticus and red tilapia [Nile Tilapia × Mozambique Tilapia O. mossambicus]) and rearing water. The detection method, based on a change in color from orange to green, could be performed within 45 min at 63°C. The method was highly specific, as it had no cross-detections with 14 other bacterial species, including other fish pathogens and two Flavobacterium species. The method has a minimum detection limit of 2.2 × 102 F. columnare CFU; thus, it is about 10 times more sensitive than conventional PCR. With this method, F. columnare was detected in gonad, gill, and blood samples from apparently healthy tilapia broodstock as well as in samples of fertilized eggs, newly hatched fry, and rearing water. The bacteria isolated from the blood were further characterized biochemically and found to be phenotypically identical to F. columnare. The amplified products from the LAMP–calcein method had 97% homology with the DNA sequence of F. columnare.
Received May 21, 2014; accepted August 10, 2014
CellCODE: a robust latent variable approach to differential expression analysis for heterogeneous cell populations
Authors: Chikina Maria , Zaslavsky Elena , Sealfon Stuart C. 
Published: January 2015

Abstract
Motivation: Identifying alterations in gene expression associated with different clinical states is important for the study of human biology. However, clinical samples used in gene expression studies are often derived from heterogeneous mixtures with variable cell-type composition, complicating statistical analysis. Considerable effort has been devoted to modeling sample heterogeneity, and presently, there are many methods that can estimate cell proportions or pure cell-type expression from mixture data. However, there is no method that comprehensively addresses mixture analysis in the context of differential expression without relying on additional proportion information, which can be inaccurate and is frequently unavailable.
Results: In this study, we consider a clinically relevant situation where neither accurate proportion estimates nor pure cell expression is of direct interest, but where we are rather interested in detecting and interpreting relevant differential expression in mixture samples. We develop a method, Cell-type COmputational Differential Estimation (CellCODE), that addresses the specific statistical question directly, without requiring a physical model for mixture components. Our approach is based on latent variable analysis and is computationally transparent; it requires no additional experimental data, yet outperforms existing methods that use independent proportion measurements. CellCODE has few parameters that are robust and easy to interpret. The method can be used to track changes in proportion, improve power to detect differential expression and assign the differentially expressed genes to the correct cell type.
Availability and implementation: The CellCODE R package can be downloaded at http://www.pitt.edu/∼mchikina/CellCODE/ or installed from the GitHub repository ‘mchikina/CellCODE’.
Contact: mchikina@pitt.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Repulsive parallel MCMC algorithm for discovering diverse motifs from large sequence sets
Authors: Ikebata Hisaki , Yoshida Ryo 
Published: January 2015

Abstract

Motivation
The motif discovery problem consists of finding recurring patterns of short strings in a set of nucleotide sequences. This classical problem is receiving renewed attention as most early motif discovery methods lack the ability to handle large data of recent genome-wide ChIP studies. New ChIP-tailored methods focus on reducing computation time and pay little regard to the accuracy of motif detection. Unlike such methods, our method focuses on increasing the detection accuracy while maintaining the computation efficiency at an acceptable level. The major advantage of our method is that it can mine diverse multiple motifs undetectable by current methods.

Results
The repulsive parallel Markov chain Monte Carlo (RPMCMC) algorithm that we propose is a parallel version of the widely used Gibbs motif sampler. RPMCMC is run on parallel interacting motif samplers. A repulsive force is generated when different motifs produced by different samplers near each other. Thus, different samplers explore different motifs. In this way, we can detect much more diverse motifs than conventional methods can. Through application to 228 transcription factor ChIP-seq datasets of the ENCODE project, we show that the RPMCMC algorithm can find many reliable cofactor interacting motifs that existing methods are unable to discover.

Availability and implementation
A C++ implementation of RPMCMC and discovered cofactor motifs for the 228 ENCODE ChIP-seq datasets are available from http://daweb.ism.ac.jp/yoshidalab/motif.

Supplementary information
Supplementary data are available from Bioinformatics online.
Changes in the lease and permanent sale quota markets of a rock lobster fishery in response to stock abundance
Authors: León Rafael , Gardner Caleb , van Putten Ingrid , Hartmann Klaas 
Published: January 2015

AbstractEffective individual transferable quotas (ITQ) systems rebuild stocks and allow transfer of quotas to more efficient operators. This process requires functional markets for both quota sales and temporary quota leases. These markets are expected to respond to changes in economic rent from the fishery, which is influenced by stock abundance and the international rock lobster price. This research used multistate Markov modelling and Granger causality test to examine changes in the permanent and temporary quota trade in the Tasmanian rock lobster fishery quota market, during periods of both increasing and decreasing stock abundance. The permanent quota trade market was more active during the period of stock growth, while the quota lease market was active in both periods of stock growth and decline. In contrast to theoretical trends in ITQ fisheries, trades in both markets were not linked to the technical efficiency (i.e. catching capability) of operators, but were more driven by the quota owners' financial capacity (i.e. number of owned quotas). Prolonged and unexpected stock decline affected the quota market so that it deviated from the theoretical pattern of ITQ fisheries. Operators previously active in the market reduced their activity, while smaller operators and firms that previously had not traded became more active, so the fleet expanded with smaller operators entering.