bluuebunny/crossref_metadata_2025_split huggingface dataset:
1683 – Social Behavior And Ultrasonic Vocalizations In Adult Mice β2-ko: Pertinence Of An Animal Model For Schizophrenia
Authors: Gankpé F.G. , Mésenge C. , Granon S. 
Published: July 2013

IntroductionIn patients suffering from neuropsychiatric disorders such as schizophrenia and depression, the neurobiological processes of decision-making are severely compromised. Some recent studies showed that social behavior and the ultrasonic vocalizations parameters in mice, expressed their emotional mood and could be used to analyze the process of decisionmaking. But, remains to highlight the modulation of these parameters under the effect of drugs, used in the treatment of these pathologies.ObjectivesThe aim was to find out the neuropharmacological modulators of decision-making in β2-ko adult male mice, suggested as animal model for schizophrenia, in order to test the pertinence of that model.MethodsWe first, administered clozapine used in the treatment of schizophrenia in human. Then, we analysed the social behavior as well as ultrasonic vocalizations parameters by Avisoft® in social interaction condition.ResultsOur results show that adult male mice β2-ko emit ultrasonic vocalizations. Under the effect of clozapine, the emission of ultrasonic vocalizations are regulated by the balance between cholinergic and dopaminergic pathways. The activation of the cholinergic together with the inhibition of the dopaminergic pathways induces a negative emotional state, showed by vocalizations with low frequency of about 50 kHz. The activation of the dopaminergic with the inhibition of the cholinergic system induces a positive emotional state, showed by vocalizations with high frequency of about 60 to 80 kHz.ConclusionsThe administration of clozapine allowed re-establishing the social behavior parameters in β2-ko mice as well as the level of wild type mice but not about vocalization.
1685 – Monitoring Clinical Observation On Acute Psychiatric Wards
Authors: Najim H. , Saleem K. , Alshibiny B. , Ezeasor N. 
Published: July 2013

BackgroundClinical observation is very important to manage risk of people who are acutely ill on psychiatric wards. It is always an area of dispute between different specialities and disciplines in serious untoward incidents(SUI). Three levels of observations have been applied on acute psychiatric words. Assessing practice is important to help identifying positive and negative aspects of clinical practice.MethodsA questionnaire was developed by HN to collect demographic. Medical notes on Westley and Grangewater wards were reviewed. Excel Microsoft Office World Computer Programme was used to analyse the results.Results57% were men.62% were above 41 years of age.Majority were suffering from schizophrenia and schizoaffective disorders 61%.64.28 % were admitted as formal patients.31.42 % were on level I observation.62.53 were informal.54.76% were risk to themselves, 28.57 % risk to others.82.3% were on level II observation, 31.42% formal and 68.50% informal.21.32% were on level III observation. 66.66% were formal and 66.66% had an incident before this level.ConclusionThis study have shown that patients are assessed properly before they go on any level of care. Some patients need to go on level III as they pose a risk mainly to other people. Regular reviews of patients, especially on high level of observation should be done more promptly, as being on observation is not a comfortable experience to go through and applying the least restrictive practice should always be sought and adopted.
1686 – Teamwork In The Multidisciplinary Melanoma Group
Authors: Scherer E.A. , Scherer Z.A.P. 
Published: July 2013

IntroductionIn the Multidisciplinary Melanoma Group (MMG) of Ribeirão Preto Medical School Hospital of the University of São Paulo, Brazil, physicians of different specialties (plastic surgery, dermatology, oncology, pathology and psychiatry) work in an integrated way and weekly provide care to outpatients with melanoma. They hold monthly meetings to: discuss administrative issues; update diagnoses, therapies and treatment protocols; discuss research projects, and bring members together.ObjectivesTo present, based on a clinical case report, a reflection about the MMG’s teamwork.AimsTo understand the teamwork of different specialties physicians in providing care to people with melanoma.MethodsCase report and reflection.ResultsWoman, 35 years-old, white, divorced, two sons (11 and 7 year-old). Primary melanoma operated 5 years before and inguinal metastases resected one month prior to the follow up at MMG. Psychiatric approach: tense, dissociated, with no knowledge about the illness’ meaning, worried about the children. Adjuvant oncologic treatment and support psychotherapy were implemented. After few months, she complained of mild fever and fatigue that interfered in relationship with her children. With change in the adjuvant treatment protocol, patient’s situation was discussed and, after risks and benefits evaluation, it was chosen to discontinue her treatment. Patient got closer to her children and more involved in psychotherapy and outpatient treatment.ConclusionThe proper use of a uniform language, the definition of roles, clear communication and concern with the aim of taking care of people with melanoma in their clinical and emotional needs facilitate the adjustment and cohesion in the MMG.
1704 – Suicide Attempts Before And During The Financial Crisis In Greece
Authors: Stavrianakos K. , Pachi A. , Paplos K. , Nikoviotis D. , Fanouraki E. , Tselebis A. , Lekka D. , Karakasidou E. , Kontaxakis V. , Moussas G. 
Published: July 2013

ObjectivePeriods of financial crises have been associated with impairment of mental health and increased suicidality. The purpose of this research is to study the potential impact of the consequences of the financial crisis, such as unemployment, job insecurity, debts, poverty, social exclusion on the suicidality in the Greek population.MethodThe records of patients who were hospitalized in the Internal Medicine Clinics of a general hospital after attempting suicide in the years 2007 and 2011, before and during the financial crisis respectively, were studied. Demographic data, methods of suicide attempt, psychiatric history and severity of psychopathology at the time of suicide attempt, were recorded for each patient.ResultsThe statistical analysis showed that during the financial crisis there is an increase in the number of suicide attempts. Most affected are those who are unemployed, married, who are reaching the age of retirement or are already retired and have no history of psychiatric disorder or suicide attempt. Furthermore, there was evidence suggesting that a decreased threshold of psychopathology was adequate for individuals to exhibit suicidal behavior.ConclusionsIt seems that the economic crisis in Greece has a negative impact on the mental health of its population and causes an increase in suicidal behavior. Consequently, mental health promotion and suicidality prevention programs are essential for the accurate and timely identification and the immediate and effective management of high risk individuals.
1705 – Prevalence Of Personality Type d In Greece
Authors: Kokras N. , Kouzoupis A.V. , Papadimitriou G.N. 
Published: July 2013

IntroductionThe type D personality (negative affectivity and social inhibition) has been associated with increased risk for adverse cardiovascular outcomes. The prevalence however of type D personality appears to vary significantly among different societies and cultures.ObjectivesThe objective of the present study was to verify the prevalence of type D personality in Greece.AimsTo identify the prevalence of social inhibition, negative affectivity and personality type D, as measured by the DS-14 scale, in Greek patients.MethodsA randomly selected sample of 100 patients with acute myocardial infarction and 100 patients with hyperparathyroidism were recruited. All patients were asked to complete the Hospital Anxiety and Depression Scale, the Athens Insomnia Scale and the DS-14 scale.ResultsSocial inhibition was present in 43% of patients suffering from hyperparathyroidism and in 55% of patients suffering from acute myocardial infarction. Negative affectivity was present in 51% of patients with hyperparathyroidism and in 68% of patients with myocardial infarction. As a result, type D personality was found to be present in 29% of patients with hyperparathyroidism and in 46% of patients with acute myocardial infarction.ConclusionsPrevalence of personality type D was found higher in Greek patients when using the translated DS-14 scale and in comparison to other european studies. Interestingly, Greek patients with acute myocardial infarction had a higher type D personality prevalence than those suffering from hyperparathyroidism, confirming that the construct of type D, however variable, might play a role in the development of cardiovascular events.
1716 – Abnormal Resting-state Functional Connectivity In Euthymic Bipolar Patients
Authors: Favre P. , Polosan M. , Pichat C. , Bougerol T. , Baciu M. 
Published: July 2013

ObjectivesBipolar disorders (BD) are characterized by emotional and cognitive impairment reflected in functional MRI studies. Although the default mode network (DMN) would be also impaired, resting-state activity was much less explored in these patients. Our current study aims to assess the DMN functional connectivity in euthymic bipolar patients (EBP) in order to identify potential trait abnormalities of this disease.MethodsFifteen EBP and 15 matched healthy controls (HC) underwent fMRI exam during 6 min resting state (rest while keeping attention focused on a visual cross on a projection screen). The Independent Component Analysis (ICA) was used to identify DMN network and functional connectivity in each subject. The DMN group maps of EBP and of HS were compared statistically. Additionally, within-group analysis was performed in EBP group to explore the effect of disease duration on functional connectivity.ResultsCompared to HC, EBP showed reduced DMN connectivity within medial prefrontal cortex, right angular gyrus and left occipital lobe as well as abnormal recruitment of right insula and right middle cingulate gyrus. For the EBP group, significant positive correlation between disease duration and functional connectivity has been observed within left amygdala and right middle cingulate cortex.ConclusionsOur results revealed decreased DMN functional connectivity within frontal and parietal regions in EBP and suggest abnormal internally-focused activity in these patients. Furthermore, the abnormal recruitment of limbic regions such as right insula, middle cingulate gyrus and amygdala may reflect emotional instability and hyperreactivity of EBP, which might be amplified with the disease evolution.
1723 – Female Prisoners And Gender Violence
Authors: Scherer Z.A.P. , Scherer E.A. ,   Interdisciplinary Study Group about Violence (GREIVI)
Published: July 2013

IntroductionViolence is one of the most serious forms of discrimination on account of sex /gender. It is a phenomenon that affects women of different social classes, ethnic and professional groups. Some of these women end up involved with situations that leads them to imprisonment.ObjectiveTo identify histories of gender violence in a feminine jail population; to analyze the relation of this violence with the imprisonment.AimsUnderstand the circumstances of gender violence that imprisoned women were exposed.MethodThematic oral history research, carried out at the Female Penitentiary in Ribeirão Preto (SP) - Brazil. A semistructured interview was applied to 15 female prisoners.ResultsThe analysis of the prisoners’ narratives allowed the identification of two categories: “involvement with criminal partners” and “victimization and violence cycle”. In both, the interviewed women understood that they were dominated by men and considered the violence against them deep-rooted in human culture. They claimed that their involvement in criminal activities, mainly drug trafficking, was under the influence or enticement by companions. Some of them were arrested because they carried drugs to their partners inside male penitentiaries. They said that they had no alternative to the criminal activity as there were no social support and opportunities.ConclusionThe complexity of violence against women makes necessary the implementation of health, social assistance and education public policies that comprise combat, prevention, assistance and assurance of women’s rights.
1731 – The Relationship Between Pain Symptoms, Anxiety And Perceived Family Support In Lung Cancer Patients
Authors: Lekka D. , Tselebis A. , Bratis D. , Zafeiropoulos G. , Nikoviotis D. , Karkanias A. , Syrigos K. , Moussas G. 
Published: July 2013

IntroductionLung cancer is a stressful condition for both patient and family. The anxiety and pain accompanying cancer and its treatment have a significant negative influence on the patient’s life quality.AimsTo investigate the correlation between anxiety, pain and perceived family support in a sample of lung cancer patients.MethodsThe sample consists of a total of 101 lung cancer patients hospitalized at the oncology department of a general hospital. Anxiety, pain (severity and interference) and perceived family support were assessed using Spielberger’s State - Trait Anxiety Inventory (SSTAI), the Brief Pain Inventory (BPI) and the Family Support Scale (FSS) respectively.ResultsAnalysis showed that there is a correlation between anxiety, pain and family support as perceived by the patients. Pain intensity (severity and interference) has a positive correlation to both state and trait anxiety and a negative correlation to family support. The effects of pain in everyday life also exhibit a positive correlation to state and trait anxiety and a negative correlation to family support. Anxiety (state and trait) has a significant negative correlation to family support.ConclusionsPain intensity in lung cancer patients seems to have an effect on patient anxiety and perceived family support. Treating patients’ pain could lead to a decrease in anxiety symptoms as well as an increase in perceived family support.
1738 – The Lethal Potential Of Lamotrigine - Dress Syndrome
Authors: Vila Nova V. , Cotta C. , da Ponte G. , Mendes S. 
Published: July 2013

IntroductionThe Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction of delayed onset. It is characterized by a severe skin eruption, fever, hematologic abnormalities, and internal organ involvement, potentially life-threatening. His incidence ranges from 1 in 1000 to 1 in 10,000 drug exposures. More than 50 drugs have been reported to induce DRESS, however anticonvulsants account for one third of the drugs causing DRESS.ObjectiveTo Highlight to the knowledge of potential adverse effects of psychiatric drugs.MethodsTo describe and discuss a case report of DRESS Syndrome induced by Lamotrigine in a patient with bipolar disorder, using medline database.ResultsThe pathogenesis of DRESS syndrome is not fully understood. However, his death rate is up to 10%, what makes his recognition very important. From all the drugs that can cause DRESS, lamotrigine, used in psychiatry as mood stabilizer, is the second principal drug related to it, next to carbamazepine.ConclusionAlthough, this syndrome is mainly managed in non-psychiatric units, a psychiatrist must know the potential reactions to the drugs he uses. The psychiatrist must be able to warn the patient and to suspect of this clinical identity, in to order to a quicker and better managing of these cases. This subject is an example how psychiatry and medicine are linked and how important is a multidisciplinary approach of a psychiatric patient.
1739 – Obsessive Symptoms Onset Ay Childbirth
Authors: di Giacomo E. , Colmegna F. , Vergani P. , Pucci B. , Tabacchi T. , Clerici M. 
Published: July 2013

AimsObsessive compulsive disorder (OCD) is relatively more frequent in pregnancy (third trimester) -3,5%- and post partum - 4 to 9%. Puerperium is at risk for onset of OC disorder and OC personality disorder. Most common obsession are contamination (75%), aggressive (33.3%), and symmetry/exactness (33.3%), and the most common compulsions are cleaning/ washing (66.7%) and checking (58.3%). OC personality disorder is a risk factor for post partum onset of OCD.MethodsWe selected women during their admission for delivery (n = 61) and analyzed: sociodemographically and through administration of EPDS, BDI, BAI, WHOQOL and SCID II (comparing Obsessive-Compulsive patients [OC=32] with negative patients [NEG=11]). Time of recruitment: 2 weeksResultsLabor: Emergency cesarian OC (21,4%) vn NEG (10,3%)Previous treatment: OC (outpatient department+ private psychiatrist+ psychologist) 11,1% vs NEG 0%; only Psychologist OC 16,7% vs NEG 6,3%Past drug intake: Antidepressant OC 11,1% vs NEG 0%Miscarriage: OC (22,2%) vs NEG (31,3%)Previous Oestroprogestinic intake : OC (66,7%) vs NEG (81,3%)Complication during pregnancy: OC (38,9%) vs NEG (21,9%)Whoqol psychological: OC (22,05) vs NEG (23,66) p = 0,46; environment: OC (28,32) vs NEG (31,09) p=0,015; physical: OC (23,37) vs NEG (26,72) p=0,011BAI: OC (14,58) vs NEG (5,75) p=0,0005BDI: OC (5,63) vs NEG (1,72) p< 0,0001ConclusionsThe groups clearly differ. From a test analysis we can underline that OC feels less confident in their environment and perceives less Physical wellness. BAI and BDI are statistically different, even if OC scores small level of anxiety or depression.
1741 – Social Cognition In a Case Of Amnesia With Neurodevelopmental Mechanisms
Authors: Markowitsch H.J. , Borsutzky S. , Staniloiu A. 
Published: July 2013

IntroductionCo-occurring impairments of episodic-autobiographical memory and theory of mind were described in several psychiatric and neuropsychiatric disorders. Despite sophisticated elaborations in theoretical domains, the relationship between episodic-autobiographical memory and social cognition remains unelucidated.ObjectivesThis work’s objectives are establishing greater recognition of the possible contribution of episodic - autobiographical memory to social cognition, by resorting to data from developmental amnesia (a condition with onset in early childhood, caused by relatively selective bilateral damage to hippocampi).AimsWe describe a young adult with amnesia with neurodevelopmental mechanisms.MethodsThe patient was investigated medically, psychiatrically, with extensive neuropsychological methods and with neuroimaging.ResultsNeuroimaging revealed grossly reduced hippocampi volumes bilaterally. There was no evidence of pathology in the underlying parahippocampal region or other areas. Performance on tasks that tapped on various aspects of social cognition was non-uniform, ranging from within normal limits to moderate impairment.ConclusionsAccording to our knowledge, this is among the first case reports about a comprehensive evaluation of social information processing in a patient with amnesia with neurodevelopmental mechanisms. This patient showed impairments in performance in some laboratory tasks for social cognition, but not in others. This suggests that various components of social cognition may have different neural correlates; their unraveling may aid understanding of when and how episodicautobiographical memory contributes to social cognition. This study also emphasizes the need to employ various tasks to assess social cognition in patients with amnesia, which go beyond traditional laboratory paradigms.
1756 – Child Sexual Abuse Andnarcissism: a Case Report
Authors: di Giacomo E. , Aspesi F. , Clerici M. 
Published: July 2013

Child Sexual Abuse has a wide range of connotations. Psychiatric implications often include depression, post-traumatic stress disorder, and also self-harming behavior. Moreover it often determines personality correlates (in particular Borderline Personality Disorder).In this contribution we report an explicative case of the consequences linked to child sexual abuse.Patient: Male, 40 ys, divorced, one son (11 ys). He reports child sexual abuse by both parents (7 to 12 ys). Abuses ended when he fight with his father using a knife. He worked for an airline company, but was fired for an excess of work absence due to pathology. Since adolescence he presented obsessive-compulsive behavior, anxiety, mood instability, impulsiveness, flash backs, nightmares, attention difficulties and sleep disorder (linked to the idea of his own death during sleeping).Clinical diagnoses: Post Traumatic Stress Disorder and Obsessive Compulsive Disorder (Axis I), and Personality Disorder NAS with obsessive compulsive and narcissistic traits (Axis II). He complains about side effects due to many drugs (different antidepressants, antipsychotics and mood stabilizers), but shows small responsiveness.Test:WAIS-R: I.Q.=105RORCHACH: a personality organized with narcissistic defenses due to relational defects linked to self and identity definition.SCID-II: Personality Disorder NAS with obsessive compulsive and narcissistic traits.
1763 – Effectiveness And Safety Of Rapid Clozapine Dose Titration
Authors: Ifteni P. , Manu P. 
Published: July 2013

BackgroundClinical guidelines recommend slow clozapine dose titration, a procedure introduced in the 1980's to decrease the risk of drug-induced seizures and hypotension. The procedure is considered safe, but may delay adequate control of symptoms.ObjectiveTo evaluate the effectiveness and safety of rapid clozapine dose titration in schizophrenia patients at high risk of harming themselves or others.MethodsThe rapid clozapine dose titration was used for a consecutive cohort of schizophrenia patients (N = 111, mean age 42.1%, 52% males) admitted to a single psychiatric hospital. Clozapine was started with a dose of 12.5–25 mg and additional doses of 25–50 mg where given as needed every 6 hours. The clozapine treatment was intiated on admission for 73 patients who had been treated with clozapine in the past (Group 1). Thirty-eight patients received clozapine after failing to respond to other antipsychotics (Group 2).ResultsAdmission PANSS scores were similar in the 2 groups (104.3 ± 2.9 vs. 103.8 ± 5.1, p = 0.48). Symptom control was obtained after 4.1 ± 3.1 days with a maximum dose of 352.7 ± 176.1 mg clozapine/day in group 1 and after 7.1 ± 4.8 days (p < 0.001) with a maximum dose of 408.6 ± 187.5 mg clozapine/day (p = 0.12) in Group 2. The PANSS scores at discharge indicated similar reduction in symptom severity (60.5 ± 5.4 vs. 59.8 ± 7.4, p = 0.539). None of the patients treated had seizures, syncope, neutropenia or other significant adverse events.ConclusionsRapid clozapine dose titration appears safe and effective when used in schizophrenia patients with or without prior exposure to the drug.