bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant Chemotherapy In Stadium Ib3, Iia2 And Iib Cervical Cancer
Authors: Winata I Gde Sastra GdeSastra 
Published: July 2024

Aim:Â This studyÂ aimed to describe Paclitaxel-Carboplatin chemotherapy as neoadjuvant chemotherapy in stage IB3, IIA2 and IIB cervical cancer.Â Materials and Methods:Â The review was conducted by collecting journals from previous studies discussing neoadjuvant chemotherapy in cervical cancer stages IB3, IIA2, and IIB and in this case specifically discussing Paclitaxel-Carboplatin chemotherapy.Â Results:Â Neoadjuvan chemotherapy refers to systemic therapy intended to reduce the size of the tumor before the definitive operation. Several studies have shown that neoadjuvant chemotherapy has greater advantages than surgery alone for early stage cancers (IB3, IIA2, and IIB). Paclitaxel and Carboplatin are known chemotherapeutic agents that can be used as neoadjuvant chemotherapy.Â Conclusions:Â Neoadjuvant Chemotherapy regimen Paclitaxel Carboplatin is one of the options in performing therapy for early stage cervical cancer which can be very helpful in healing and cancer-free patient condition. Neoadjuvant chemotherapy followed by radical surgery has significant benefits that have been described in several previous studies.Â Â Clinical Significance:Â Neoadjuvant Chemotherapy regimen Paclitaxel Carboplatin may be used as therapy regimen for early stage cervical cancer with all advantage compared to only surgery. Thus, this type of regimen can be used to decrease mortality and morbidity in patient with stadium IB3, IIA2 and IIB cervical cancer.Â
Odrzucenie Jezusa w Jego rodzinnym mieście. Analiza egzegetyczno-teologiczna passusu Mt 13,54-58
Authors: Kędziora Daniel 
Published: July 2024

Kontekstem badań było doświadczenie życiowe, że akceptacja lub odrzucenie człowieka w określonej grupie społecznej ma ogromny wpływ na prawidłowy rozwój osoby w przestrzeni życia zarówno prywatnego, jak również zawodowego. Również autorzy biblijni przedstawiają to trudne doświadczenie – począwszy od Księgi Rodzaju i nieposłuszeństwa pierwszych ludzi.Celem badań był przypadek odrzucenia w Nowym Testamencie. Taki przykład znajduje się w passusie Mt 13,54-58 (przybycie Jezusa do swojego rodzinnego miasta – Nazaretu). Analiza tekstu biblijnego pozwala na postawienie pytań badawczych: Czy Jezus miał braci i co o nich wiemy? Co kryje się pod terminem „ojczyzna”? Jakie było znaczenie relacji rodzinnych w czasach biblijnych? Jaka jest prawdziwa tożsamość Jezusa z Nazaretu? Jaka jest rola wiary w zaistnienie cudu?Do badań wykorzystano metodę historyczno-krytyczną. Zgodnie z tą metodą poddano szczegółowej analizie literackiej tekst Mt 13,54-58. Dokonano delimitacji tekstu (wyznaczenia granic). Określono także konteksty: poprzedzający i następujący. Został zawarty tekst grecki wraz z transliteracją oraz przekładem na język polski. Przeprowadzona krytyka tekstu wskazuje na różnice wśród świadków tekstu. Ukazano też kontekst synoptyczny.W wyniku przeprowadzonych badań udało się także zaproponować strukturę badanego tekstu. W kolejnych etapach zawarto komentarz egzegetyczny oraz analizę teologiczną.Wnioski z przeprowadzonych badań odnoszą się do teologii pastoralnej i duchowości.
Study of Clinical and Haematological Profile of Vitamin b12 Deficiency and to Check Response to Vitamin b12 Therapy
Authors: Aher Archana , Navghare Pankaj , Zawar Shyam 
Published: July 2024

Objectives:
Vitamin B 12 (cobalamin) deficiency has been a known clinical entity for long time. Average Indian diet is deficient in vitamin B12. Deficiency of vitamin is associated with a wide spectrum of haematologic and neuropsychiatric disorders that can often be reversed by early diagnosis and prompt treatment. Diagnosis is easy and treatment ids cheap. Hence, we conducted this study to find patterns of presentation in patients with vitamin B12 deficiency with haematological profile and to check response to therapy.

Material and Methods:
A longitudinal study was conducted between September 2016 and November 2018 in the Department of Medicine at Government Medical College, Nagpur, India. One hundred patients whose serum vitamin B12 level was <250 pg/mL were included in the study.

Results:
Mean vitamin B12 level in patients was 162.64 ± 43.31 pg/mL. Most of patients were male and deficiency was common among vegetarians. History of alcoholism was present in 41% of patients. The most common complaint was fatigue present in 87% of patients. Most common neuropsychiatric complaint was tingling and numbness (14%). Most common sign elicited was pallor in 96% of patients while icterus and knuckle hyperpigmentation was present in 57% and 74% of patients, respectively. Mean haemoglobin (Hb) among cases was 6.09 ± 2.21 g/dL. After treatment, all the patients showed a dramatic response in Hb level, mean corpuscular volume, red cell distribution width and mean platelet volume.

Conclusion:
Deficiency of vitamin B12 is associated with plethora of clinical manifestations. Males, alcoholics and vegetarians are at risk. Early treatment halts late complications.
The Semiology of Title Poeticness in Jabar Jamal Gharib's "The flying Birds that are Dross" novel
Authors: Perdawd Hasan Abdulstar , Ahmad Hasan Gardi Sardar 
Published: July 2024

This study is entitled (The Semiology of Title Poeticness in Jabar Jamal Gharib's "The flying Birds that are Dross" novel). The study attempts to shed light on an essential and influential subject which is the semiology of title poeticness. It introduces the term and concept of semiology of title poeticness and its value as a semiological icon within a broad genre like novel. There has not been much research in Kurdish literary works aimed at presenting the role and position of semiology of title poeticness in the genre of novel. Hence، the current study highlights the hidden aspects of semiology of title poeticness، that is، it uncovers the meanings behind the masks of the titles at each level of morphology، syntax، rhythm and melody and meaning within the above-mentioned novel. The poetic titles are semiologically interpreted in order to highlight the writer's message behind the iconicity of the poetic-like titles.
PENGEMBANGAN E-MODUL MODEL CREATIVE PROBLEM SOLVING BERBASIS SOAL HOTS UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS DAN ADVERSITY QUOTIENT
Authors: Tri Wulan Sari  , Asmin  , Asrin Lubis  
Published: July 2024

Tujuan penelitian ini adalah untuk mengevaluasi validitas, praktis, dan efektivitas modul elektronik berbasis soal HOTS. E-Module dirancang untuk meningkatkan kemampuan pemecahan masalah matematis dan adversity quotient siswa kelas XMAN 2 Langkat. Untuk mengevaluasi kemajuan yang dicapai siswa dalam memecahkan masalah matematika di kelas. Memastikan sejauh mana peningkatan adversity quotient siswa yang mengikuti kelas penelitian pembangunan berbasis ADDIE. Subjek dalam penelitan ini adalah peserta didik kelas X yang berjumlah 72 0rang siswa. Mtode penelitian ini penelitian pengembangan model ADDIE. Hasil yang diperoleh adalah: E-modul yang dibangun menunjukkan bahwa e-modul dan perangkatnya telah diakui valid, praktis, dan bermanfaat oleh para profesional yang menyatakan bahwa perangkat pembelajaran layak digunakan; Berdasarkan indeks gain ternormalisasi, kemampuan pemecahan masalah matematis siswa meningkat pada uji coba I yang memperoleh nilai “Rendah” sebesar 0,298 (0,3), dan pada uji coba II memperoleh nilai “Tinggi” sebesar 0,489. (0,3 lebih kecil dari N-Gain). Peningkatan kemampuan siswa dalam mempertanyakan kesulitan baik pada uji coba I maupun uji coba II ditunjukkan berdasarkan analisis statistik. Persentase peserta camper pada tes I sebesar 9,72%, sedangkan persentase peserta camper pada uji coba II sebesar 0%. Persentase peserta camper yang beralih menjadi pendaki sebesar 79,16% dan 58,33%, serta persentase pendaki sebesar 11,12% hingga 38,77%. Hasilnya, kemampuan siswa dalam merespons pertanyaan-pertanyaan menantang secara efektif meningkat drastis dari uji coba I ke uji coba II.
Pathogen prioritisation for wastewater surveillance ahead of the Paris 2024 Olympic and Paralympic Games, France
Authors: Toro Laila , de Valk Henriette , Zanetti Laura , Huot Caroline , Tarantola Arnaud , Fournet Nelly , Moulin Laurent , Atoui Ali , Gassilloud Benoît , Mouly Damien , Jourdain Frédéric 
Published: July 2024

BackgroundWastewater surveillance is an effective approach to monitor population health, as exemplified by its role throughout the COVID-19 pandemic.AimThis study explores the possibility of extending wastewater surveillance to the Paris 2024 Olympic and Paralympic Games, focusing on identifying priority pathogen targets that are relevant and feasible to monitor in wastewater for these events.MethodsA list of 60 pathogens of interest for general public health surveillance for the Games was compiled. Each pathogen was evaluated against three inclusion criteria: (A) analytical feasibility; (B) relevance, i.e. with regards to the specificities of the event and the characteristics of the pathogen; and (C) added value to inform public health decision-making. Analytical feasibility was assessed through evidence from peer-reviewed publications demonstrating the detectability of pathogens in sewage, refining the initial list to 25 pathogens. Criteria B and C were evaluated via expert opinion using the Delphi method. The panel consisting of some 30 experts proposed five additional pathogens meeting criterion A, totalling 30 pathogens assessed throughout the three-round iterative questionnaire. Pathogens failing to reach 70% group consensus threshold underwent further deliberation by a subgroup of experts.ResultsSix priority targets suitable for wastewater surveillance during the Games were successfully identified: poliovirus, influenza A virus, influenza B virus, mpox virus, SARS-CoV-2 and measles virus.ConclusionThis study introduced a model framework for identifying context-specific wastewater surveillance targets for a mass gathering. Successful implementation of a wastewater surveillance plan for Paris 2024 could incentivise similar monitoring efforts for other mass gatherings globally.
Situated and sequential planning and prediction of human driving behavior as decision making support system
Authors: Bejaoui Abderahman , Söffker Dirk 
Published: July 2024

The realization of safe networked traffic is getting more and more important. The planning and prediction of possible driving behaviors and the detection of missing actions in advance contribute to avoid critical situations. A decision making system enables the support the human operator (driver) and to supervise the human-machine interaction by proposing possible actions predicted by the system, by warning him or her by detecting critical situations, and to take over the driving functionality if necessary.The contribution of the work is the development of a monitoring decision making system allowing the planning and prediction of possible driving behaviors, detection of missing actions, and to support the human operator to reach desired situations. A Situation Operator Modeling method is used as event-discrete approach to describe changes from the real world as well as driving behaviors as a graph-based model considering the changes in the environment. The behaviors of traffic-vehicles are calculated based on predicted trajectories using a Long Short-Term Memory (LSTM) Encoder Decoder algorithm. The approach is applied to an ’overtaking maneuver on a highway’. Decision options can be continually generated depending on the changes in the environment, can be suggested to the driver, and can support him or her to lead desired situations.
Coletânea Modernidade e humanização: inclusão, permanências, terapias e psique - Volume 1
Authors: Lima Gabriel Nava , Zeidan Fernanda Tabita Barroso 
Published: July 2024

As relações sociais passaram a ser virtuais. O contato entre pessoas está perdendo a materialidade e migrando para redes sociais virtuais ou passando a se realizar via aplicativos para celular. Este livro trata dessa realidade ao debater de forma direta ou indireta os transtornos nascidos do uso excessivo de telas e da imersão nas redes sociais, discutindo a manutenção de preconceitos e a luta pela inclusão sem estereótipos e, avaliando terapias capazes de auxiliar os indivíduos a manterem a humanidade em uma realidade fluída – e as vezes efêmera. O livro também analisa os transtornos que acometem o homem moderno e que passaram a ser definidos de forma mais nítida como o TEA, a Depressão e a Ansiedade. Os artigos que fazem parte do livro não estão interligados, mas trazem em si um mosaico de temas que caracterizam a vivência e forma como a humanidade sobrevive a modernidade.
Características clínicas de una serie de casos de pacientes con angiotomografía positiva para embolismo pulmonar en un servicio de urgencias en Cali, Colombia
Authors: Mendez Jimenez Frank Brayan , Moncada Reyes Cindy Catherine , Passos Rangel Ximena Andrea , Padilla Melo Jhon Freddy 
Published: July 2024

Introducción. El tromboembolismo pulmonar (TEP) es la obstrucción que se produce en la arteria pulmonar o alguna de sus ramas a causa de un émbolo o trombo que se genera predominantemente a nivel de las extremidades inferiores. Este continúa siendo un motivo frecuente de ingreso al servicio de urgencias, no obstante, las características clínicas en el servicio de urgencias no están descritas de manera específica y en ocasiones está subdiagnosticado, con elevadas tasas de mortalidad. Objetivo. Se describieron las características clínicas más comunes de los pacientes que se presentan al servicio de urgencias de manera espontánea en una institución de alta complejidad de la ciudad de Santiago de Cali, Colombia y son diagnosticados con TEP mediante angiotomografía de tórax.
Materiales y métodos. Se describieron signos, síntomas y factores de riesgo en una serie de casos de tipo descriptivo de pacientes mayores de 18 años que consultaron al servicio de urgencias con evidencia de imagenología de TEP, excluyendo pacientes embarazadas y pacientes pertenecientes a otro servicio diferente a urgencias. Se realizó un análisis bivariado utilizando medidas de proporciones, frecuencias, medias, medianas y desviación estándar. El estudio contó con aval del comité de ética en investigación.
Resultados y discusión. La taquicardia y taquipnea siguen siendo los signos más frecuentes para sospechar TEP y la disnea sigue siendo el síntoma más común, al igual que el dolor torácico en el servicio de urgencias. Respecto a los factores de riesgo, la obesidad es en nuestro estudio el factor de riesgo más presente en el TEP a diferencia de la TVP que es el factor de riesgo más común.
Acceso al tratamiento en un Programa de Soporte al Paciente con Asma grave eosinofílica en Colombia
Authors: Lopez Christian , Hurtado Fernando , Gómez Camila , Silva Maria Fernanda , Bernal Laura 
Published: July 2024

Introducción. El benralizumab es un anticuerpo monoclonal efectivo en el tratamiento de pacientes con asma grave eosinofílica no controlada a pesar de una adecuada adherencia, técnica de uso del inhalador y la administración de corticoides inhalados en dosis plenas junto con agonistas β de acción prolongada. Estas terapias innovadoras a menudo enfrentan retos en los sistemas de salud, la mayoría en términos de acceso efectivo y oportuno de los pacientes, lo que hace que los programas de soporte al paciente (PSP) puedan disminuir estas barreras de acceso, permitiendo mejoría en tiempos e identificando hitos sobre los cuales los diferentes actores del sistema pueden enfocar esfuerzos para una mayor efectividad en el acceso. Objetivo. comparar los resultados de un programa de soporte al paciente con asma grave eosinofílica en tratamiento con benralizumab y el acceso a la terapia durante 2021 y 2022 en Colombia.
Materiales y métodos. análisis descriptivo observacional retrospectivo de un programa de soporte a pacientes con asma grave eosinofílica durante 2021-2022 en Colombia.
Resultados. en ambos periodos predominó el género femenino (69.8 % y 76.2 % respectivamente), la media de edad fue de 50.8 años (DE ±11.4) (valor p: 0.395) en 2021 y de 50.7 años (DE ±11.7) en 2022. El tiempo promedio entre la prescripción y la entrega del medicamento se mantuvo en 32 días sin incremento entre los años. Al comparar los dos periodos, hubo una disminución de tres días en el tiempo promedio para la autorización del tratamiento desde la vinculación al programa, de dos días en el tiempo promedio para la entrega del medicamento desde la autorización y de cinco días en el tiempo promedio para la entrega del medicamento desde la vinculación. Las principales barreras de acceso al medicamento fueron la cita de aplicación programada (76 %) y la asignación pendiente de la cita de control <5 días (6 %) en los dos años.
Conclusiones. los programas de soporte al paciente en asma grave eosinofílica impactan en los tiempos de la ruta del paciente, la inequidad entre regímenes y desigualdad social, reduciendo la variabilidad en el acceso entre los grupos poblacionales. El seguimiento del programa evidencia una mayor experiencia en los procesos de acceso a los tratamientos, garantizando una mayor reducción de las brechas.
Synthesis and Characterization of Copper(II) Oxide (CuO-NP) Nanoparticles using Chemical Precipitation Method
Authors: Charlena Charlena , Sugiarti Sri , Ardiansyah Dila 
Published: July 2024

This study aims to optimize the calcination temperature and see the effect of adding surfactant on the bandgap, particle size, crystallinity level of CuO nanoparticles (CuO-NP), and the activity of CuO nanoparticles as an antibacterial agent. CuO-NP was successfully synthesized using the chemical precipitation method with variations in calcination temperature of 400, 600, and 800 °C with NaOH as a precipitating agent. The synthesized nanoparticles were further characterized using a UV-Vis, XRD, and SEM-EDX spectrophotometer. The value of the CuO-NP bandgap increases with increasing temperature. The bandgap gets bigger when the absorbance value gets smaller. Increasing the calcination temperature causes the crystal size of CuO-NP to become larger. The best level of crystallinity of CuO-NP was obtained at 68,31% with a calcination temperature of 600 °C. Adding 1% PVP did not significantly prevent agglomeration between CuO-NP particles, thereby increasing the size of CuO-NP particles.

Keywords: bandgap, CuO-NP, PVP, temperature
Management of battery waste recycling by electric motorbike workshops: A literature review
Authors: Purwani Annie , Budijati Siti Mahsanah , Asih Hayati Mukti 
Published: July 2024

Battery waste needs to be managed immediately and thus electric vehicles (EVs) become more popular as a sustainable replacement for internal combustion engine vehicles. This review discusses waste battery recycling industry practices and emphasizes the need for authorized battery management services for electric motorcycles. This gap allows third-party businesses not affiliated with the primary manufacturer to emerge and potentially grow sustainably. The literature review methodology involves an in-depth search of relevant literature using the Scopus database with strategically selected keywords. The VoS Viewer collects, organizes, and graphically maps references to synthesize them orderly. The search initially yielded 138 relevant articles. This number was then narrowed to 66 articles published in English journals. Thirty-nine articles were found when the search was modified to focus on full-text availability. These findings indicate an important need for more targeted research to design effective management frameworks for recycling waste batteries in electric motorbike workshops. All critical components increased waste management awareness and expertise among workshop managers, government policies, funding support, and a well-coordinated supply chain. This assessment identifies barriers to developing a viable battery waste recycling sector and makes recommendations for future policy and research initiatives.
Safety Assessment of Inactivated Whole Virion Booster Vaccine against the SARS­-CoV-­2 Virus (BelCovidVac) in Immunized Study Subjects aged 18 to 60 Years (day 28)
Authors: Stoma I. O. , Voropaev E. V. , Mikhailova E. I. , Los D. M. , Osipkina O. V. , Braga A. Yu. , Kovalev A. A. , Molchanova A. V. , Trofimova N. V. , Pershenkova O. S. , Yaroshevich B. S. , Mirge M. N. 
Published: July 2024

Relevance. According to the World Health Organization (WHO), it is not yet possible to effectively stop the spread of new strains of coronavirus [1]. At the same time, most experts and analysts in the field of medicine publicly admit that at the moment vaccination is the most powerful weapon in the fight against COVID-19 [2–6]. While vaccination, like the entire health care system, has now become an element of politics and economics, the creation of proprietary vaccine in each country has become an element of national security [7]. Aims. To evaluate the safety of the inactivated booster vaccine «BelCovidVac» in immunized study subjects from 18 to 60 years old (day 28). Materials and methods. A prospective, randomized, double-blind phase I/II trial evaluated the safety of an inactivated whole virion booster vaccine against the SARS-CoV-2 virus in two doses in healthy study subjects aged 18 to 60 years who had completed a full course of vaccination with the SARS-CoV-2 virus and/or recovered from COVID-19, which included 129 subjects (24 in phase 1 and 105 in phase 2). Results. The study reported 195 adverse reactions in 94 study subjects. The study reported 80 adverse reactions in 24 (100%) study subjects at Phase 1, and 115 adverse reactions in 70 subjects at Phase 2. The study detected mild adverse reactions in 77,50% of cases at Phase 1, and in 71,30% at Phase 2. Moreover, the study found one serious adverse reaction in 1 subject at Phase 2, which occurred as a result of taking placebo. The incidence of adverse reactions with the use of the candidate vaccine in two doses is comparable to placebo (χ2 = 3,15, p = 0,08). Conclusion. The vaccine candidate demonstrated good tolerability at both Phase 1 and Phase 2.