bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intralesional and topical treatments for Peyronie’s disease: a narrative review of current knowledge
Authors: Minore Antonio , Cacciatore Loris , Presicce Fabrizio , Iannuzzi Andrea , Testa Antonio , Raso Gianluigi , Papalia Rocco , Martini Marco , Scarpa Roberto Mario , Esperto Francesco 
Published: August 2024

Abstract
Peyronie’s disease (PD) presents a multifaceted challenge in contemporary urological practice, marked by penile deformity, pain, and the potential for erectile dysfunction. We meticulously explored the existing literature of intralesional/topical interventions, aiming to provide clinicians with a nuanced understanding of available options for comprehensive PD management. To conduct this review, we performed a systematic search using the PubMed, Scopus, and ScienceDirect databases, including the keywords of combination of the “Peyronie’s disease/plastic induration of the penis (PIP) and intralesional/topical treatments”. The study selection was based on adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, resulting in the inclusion of 16 articles. We delve into the effectiveness and safety profiles of collagenase Clostridium histolyticum (CCH), interferon, platelet-rich plasma (PRP), hyaluronic acid, botulinum toxin, stem cell, extracorporeal shock wave therapy (ESWT), and traction therapy, assessing their impact on penile curvature, length improvement, and patient-reported symptoms and outcomes. The best options evaluated are intralesional injections of CCH and penile traction devices, alone or in combination. Despite PD remains a challenge for urologists, the objective of this review is to contribute to the evolving landscape of PD management, fostering informed decision-making, and personalized care for individuals grappling with this challenging condition.
Evaluating the impact of Gayatri Mantra chanting and meditation on treatment outcomes in patients with chronic spontaneous urticaria: A prospective study
Authors: Samajdar Shambo Samrat , Joshi Shashank R. , Mukherjee Shatavisa , Samajdar Shinjini , Moitra Saibal , Dutta Rathindra Nath 
Published: August 2024

ABSTRACT

Background:
Chronic spontaneous urticaria (CSU) is a long-lasting skin condition marked by the appearance of hives and angioedema, which significantly impacts quality of life. Despite standard pharmacotherapies, many patients remain symptomatic, necessitating the exploration of complementary treatments. This study examines the effects of integrating Gayatri Mantra (GM) chanting and meditation with conventional pharmacotherapy on CSU management.

Materials and Methods:
This study was conducted at the Diabetes and Allergy Asthma Therapeutics Specialty Clinic in Kolkata, India, this prospective observational study included 119 patients with CSU who had been on antihistamines for at least 6 months. Participants were randomized into two groups: Group A received standard pharmacotherapy, and Group B received the same pharmacotherapy along with daily GM chanting and meditation. Primary outcomes measured were the Urticaria Activity Score 7 (UAS7), Beck Anxiety Inventory (BAI), Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL), and Dermatology Life Quality Index (DLQI) assessed at baseline and after 6 months.

Results:
Both groups showed significant improvements in UAS7, CU-Q2oL, and DLQI scores posttreatment. However, Group B, which participated in GM chanting and meditation, exhibited more pronounced improvements: UAS7 scores were reduced by 49.4% compared to 41.9% in Group A; CU-Q2oL scores by 52.9% compared to 42.5%; and DLQI scores by 73.7% compared to 60.5%. The reductions in BAI scores were also significantly greater in Group B (42.3% reduction) compared to Group A (4.96%).

Conclusion:
The addition of GM chanting and meditation to standard pharmacotherapy for CSU significantly enhances the effectiveness of treatment, suggesting that this integrative approach could provide substantial benefits in the management of CSU. These findings advocate for the incorporation of spiritual and meditative practices alongside conventional medical treatments to achieve better patient outcomes.
Comparative Evaluation of the Efficacy of ProTaper & Mtwo Rotary Retreatment System and Conventional Hand H-files for Removal of Gutta-percha from Root Canal - A Stereomicroscopic Study
Authors: Chudasama Krutika D. , Chokshi Shraddha , Sanghvi Zarana , Patel Nishit , Vaidya Naman , Chhaya Deesha 
Published: August 2024

Abstract

Background:
Root canal retreatment aims to eliminate or substantially reduce the microbial load from the root canal and removal of previous root filling materials is the primary goal of nonsurgical retreatment.

Aim:
To comparatively evaluate the effectiveness of ProTaper retreatment files, Mtwo retreatment files, and Hedstrom files along with Gates Glidden (GG) Drill by using a stereomicroscope for the detection of remaining gutta-percha after root canal retreatment using a stereomicroscope.

Materials and Methods:
Forty-five test samples were divided into three experimental groups (15 samples each), such as Group A—ProTaper retreatment files; Group B—Mtwo retreatment files; Group C—Hedstrom files along with Gates Glidden Drill. After routine endodontic treatment in the test samples, gutta-percha was removed from the test samples as per the division of different retreatment file systems. Further, test samples were divided longitudinally and were evaluated under the stereomicroscope. Stereomicroscopic images were captured and analysed under Image Analyser Software—Image J.

Statistical Analysis:
One-way ANOVA test was used for comparison of gutta-percha removal between the groups and Tukey’s post hoc test was used for pairwise comparisons.

Results:
The least remaining filling material was seen in specimens retreated with the ProTaper universal system. The highest remaining filling material was seen in specimens retreated with Hedstrom file with Gates Glidden Drill.

Conclusion:
All experimental test techniques left gutta-percha remnants within the root canal. ProTaper universal rotary retreatment system proved to be an efficient method of removing gutta-percha and left relatively less volume in comparison with other test systems.
Oral Risk Factors in Patients with Cancer Undergoing Chemotherapy - A Pilot Study
Authors: Aradya Anupama , Kiran P. K. , Raghavendra Swamy K. N. , Doddawad Vidya G. , Ranganatha Narahari , Sravani Koduru 
Published: August 2024

Abstract

Background:
Treatment modalities for cancer including surgery, radiotherapy and chemotherapy, have some complications even in the oral cavity. The literature describes oral lesions that may arise as a result of chemotherapy. However, information regarding oral symptoms in advanced cancer patients is poor.

Objective:
To identify the oral manifestations like oral mucositis, dry mouth and loss of taste in patients undergoing chemotherapy treatment.

Methods:
We evaluated 60 patients affected by malignancy undergoing chemotherapy treatment. The clinical and pathological data such as age, gender, diagnosis of malignancy and types of treatments with anticancer chemotherapeutic drug treatment, were obtained. Patients were routinely evaluated for the presence of oral mucositis based on the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 scale for adverse effects and graded. Other findings like dry mouth and loss of taste were recorded.

Results:
Of the 60 patients, 40 (66.6%) were male, and 20 (33.3%) females with a mean age of 53.7 years. Most patients about 63% and 83% were diagnosed with dry mouth and loss of taste, respectively and 71% of patients had mucositis. Chemotherapy drugs like Cyclophosphamide, carboplatin, nanoxel, paclitaxel, oxaliplatin, docetaxel and doxorubicin, were directly associated with oral mucositis.

Conclusion:
Patients treated with chemotherapy for cancer most often suffer from a multitude of intense and debilitating oral dysfunctions. Oral lesions found in patients undergoing chemotherapy were mucositis, dry mouth and loss of taste. These adverse effects and an appropriate symptomatic therapy need to be discussed with the patients. Chemotherapy has a significant but transient effect on the oral symptoms.
Trichofolliculoma - A Case Report
Authors: Suganya G. , Srinath Sahana , Chandrakala J , Yadav Satish T 
Published: August 2024

Abstract
Trichofolliculoma is a rare benign, hamartomatous adnexal tumour of the skin. Aetiology seems to be unclear. It is usually seen in adults, with no gender predilection. The most commonly involved sites are the face and scalp. It appears as a papule or nodule with small protruding hairs, which is a classic feature of the tumour. It has unique diagnostic and histopathological features that help in making a definitive diagnosis. Here, we report an exemplary case of an adult male patient aged 45 years with a gradual progressive diffuse swelling on the left side of the face for 1.5 years. Clinically, it was diagnosed as a sebaceous cyst, but after the biopsy histopathological evaluation was performed, and the diagnosis was confirmed as trichofolliculoma.
Serum Lipoprotein(a) and Angiographic Severity of Coronary Artery Disease in Asian Indians
Authors: Sandhu Arshdeep Singh , Ahmed Imran 
Published: August 2024

Abstract

Background:
With the renewed interest in lipoprotein a (Lp(a)) shown by the European Atherosclerosis Society in relation to cardiovascular disease occurrence worldwide and especially in the South Asian population, its estimation once in a lifetime has been recommended (1–3). However, the role of this proatherogenic Lp(a) in regulating the severity of angiographic lesions in coronary artery disease (CAD) is poorly understood. This study aimed to correlate the serum Lp(a) level with angiographic lesion severity in subjects with CAD.

Subjects and Methods:
In this cross-sectional study, a total of 100 adult patients (mean age: 52.56 [±12.84] years, 84 [84%] males) with angiographically confirmed CAD were enrolled in a tertiary care hospital in Eastern India and their serum Lp(a) levels were estimated (by immunoassay method) and correlated with the SYNTAX score groups (<22, 22–33, and >33) and extent of disease – single-vessel disease (SVD), double-vessel disease (DVD), or triple-vessel disease (TVD).

Results:
Mean serum Lp(a) was elevated in the more severe disease group with SYNTAX >33 (88.79 mg/dl) than in lesser severity disease groups of SYNTAX 22-33 (57.07 mg/dl) and SYNTAX <22 (35.13 mg/dl), and this trend was found to be significant by analysis of variance (ANOVA) (P < 0.001). Mean levels of Lp(a) were lower in patients with SVD (33.15 mg/dl) and DVD (33.93 mg/dl) than in those with the TVD group (77.71 mg/dl), and this trend was found to be significant by ANOVA (P < 0.001).

Conclusion:
Serum Lp(a) values had a high significant positive correlation with the angiographic severity (higher SYNTAX score and Multivessel CAD) in patients of CAD in this study. Lp(a) is a known risk factor for CAD in South Asians and statins do not appear to decrease their levels; further, our study compounds the problem by correlating its level with increasing severity of CAD. This study therefore asserts the importance of the estimation of Lp(a) in South Asian individuals and proposes larger studies to confirm its correlation with the severity of CAD.
Pattern of Coronary Angiography in Young Adults versus Older Adults Presented by Coronary Artery Disease in Correlation to Their Risk Factors with 1-year Follow-up of Their Clinical Outcome
Authors: El-Rabbat Khaled , Zarif Bassem , Elhafeez Mohammed Soliman Abd , Saeed Mahmoud 
Published: August 2024

Abstract

Background:
Coronary artery disease (CAD) is a leading cause of mortality worldwide, with varying patterns and risk factors across different age groups. While CAD is common in older adults, data on young adults are limited, with traditional risk factors and familial history playing a significant role in early disease development. The purpose of this study was to compare the coronary angiographic patterns in young adults (<40 years) and older adults (≥40 years) presented with CAD, assess the correlation with risk factors, and monitor clinical outcomes after 1 year.

Patients and Methods:
This retrospective cohort study was conducted at the National Heart Institute, including 2204 consecutive patients undergoing coronary angiography and/or percutaneous coronary intervention for CAD from January 2019 to January 2020. Patients were divided into two groups based on age: group A (<40 years) and Group B (≥40 years). Angiographic findings, risk factors, and clinical outcomes were assessed and compared.

Results:
Group B had significantly higher rates of hypertension (63.6% vs. 22.2%, P < 0.001), diabetes (53.5% vs. 24.1%, P < 0.001), and female gender (29% vs. 11.1%, P < 0.001) compared to Group A. Group A showed higher smoking rates (70.4% vs. 46.5%, P < 0.001) and positive family history (42.6% vs. 4.4%, P < 0.001). Angiographic findings revealed higher rates of single-vessel affection, coronary ectasia, aneurysm, and slow flow phenomenon in Group A, whereas Group B demonstrated more bifurcation lesions, chronic total occlusion, and calcification.

Conclusions:
This study highlights the need for age-specific approaches in managing CAD, with younger patients showing early disease onset and older patients exhibiting more complex disease. Tailored cardiovascular care is essential, focusing on lifestyle modifications in younger adults and managing metabolic conditions in older adults.
Successful Percutaneous Closure of an Undiagnosed Patent Ductus Arteriosus Causing Type 2 Endoleak
Authors: Moosavi Jamal , Sadeghipour Parham , Mohebbi Bahram , Bagheri Yaghoob , Mehdinejad Esmaeil , Jolfayi Amir Ghaffari , Sheibani Mehdi 
Published: August 2024

Abstract
Thoracic endovascular repair (TEVAR) is a valuable alternative to open surgical repair for aortic aneurysms, offering several benefits. However, one potential complication that demands attention is endoleak. This case report highlights a unique occurrence of type 2 endoleak, typically associated with aortic aneurysms treated by TEVAR, originating from an undiagnosed patent ductus arteriosus (PDA). The patient, a 68-year-old woman, underwent TEVAR for an aortic aneurysm complicated by underlying lung disease and pulmonary artery hypertension. During the procedure, an unexpected shunt between the aorta and the pulmonary artery was identified and subsequently revealed to be an undiagnosed PDA. Remarkably, the decision was made to continue with TEVAR while simultaneously deploying a stent graft to close the PDA. This case underscores the significance of comprehensive preprocedural aortic assessment and careful consideration of PDA closure to prevent type 2 endoleak in TEVAR, reinforcing the importance of thorough evaluation before such procedures.
Successful Retrograde Intrarenal Surgery for a Large Kidney Stone in a Pelvic Ectopic Kidney: A Case Report and Review of Literature
Authors: Afdal Afdal , Latief Aditya Akbar , Steven Steven 
Published: August 2024

An ectopic kidney is a condition in which one or both kidneys are located outside of their normal anatomical position, typically lower than usual, and are prone to stone disease. In the past, most patients required open surgical treatment, but nowadays, laparoscopy-assisted percutaneous nephrolithotomy and multisession retrograde intrarenal surgery (RIRS) facilitate minimally invasive approaches. A 42-year- old male presented to the urology clinic with complaints of intermittent lower midabdominal pain near the suprapubic area for a year. A computed tomography scan evaluation of the abdomen without contrast was then performed, showing incomplete staghorn with multiple calyceal stones in the ectopic kidney, with the largest stone measuring 2 × 1.2 cm and mild hydronephrosis. A single-session RIRS was performed which successfully disintegrated the stone. This pelvic kidney, although situated within the retroperitoneum, has the bowels positioned between the front wall of the abdomen and the kidney. The successful navigation of the flexible ureteroscope through the deformed urinary tract made RIRS applicable in the presence of a urinary tract deformity. This case was managed with RIRS, which offers advantages in visualization and is considered a safer option compared to other methods.
Giant Bladder Calculus in a 70-year-old Female—A Case Report
Authors: Mhaske Sunil , Salpekar Radhika , Sabale Vilas , Agarwal Prabhav , Ghotankar Shambhavi 
Published: August 2024

Vesical calculi are unusual in females, and giant calculi (weighing >100 g) are even more uncommon, considering the advances in contemporary diagnostic modalities. The entity is associated with a variety of pestering symptoms—frequency, dysuria, and hematuria, to name a few—causing serious effects on patients’ quality of life. This report cites the case of an elderly female with a giant vesical calculus weighing 1.28 kg (12.5 cm in diameter). Our patient had no past surgical history or symptoms suggestive of bladder outlet obstruction or neurogenic bladder. As per our literature search, a stone as large as that of our patient has not yet been found in females. She underwent an uneventful open suprapubic cystolithotomy. A biopsy from a suspicious lesion during the surgery revealed squamous cell carcinoma. Given that such a large stone was found in an elderly female without any predisposing causative factors, it is worthwhile looking into the etiopathogenesis and management of giant vesical calculi.
Knowledge and Perception of Diphtheria among Residents of a Rural Community in Kaduna State, Northwest Nigeria
Authors: Babandi Z.S. , Suleiman A.G. , Darma M.A. , Indabo U.H. , Shehu S. , Hamza A.S. , Henry J. , Umar U.M. , Ojediran S.L. , Amadu L. , Ibrahim M.S. , Ejembi C.L. 
Published: August 2024

Background: Diphtheria has reemerged as a public health concern in Nigeria, with outbreaks reported across several states. Catch-up vaccination, enhanced surveillance, and risk communication were instituted to curb this. This study determined knowledge and perception of diphtheria among members of a rural community in Kaduna State, Northwestern Nigeria.
Methods: Using a cross-sectional descriptive study design, data were collected from 590 respondents drawn through multistage sampling. Composite knowledge and perception scores were computed and graded using median values as cut-off points for good knowledge and perception. The data was presented using descriptive statistics, while the chi-square test of independence was used to check for association between socio-demographic variables and outcome variables at p < 0.05.
Results: The respondents comprised 226 (38.3%) males and 364 (61.7%) females, with a mean age of 33.6 (+6.0) years. Only 117 (19.8%) respondents had ever heard of diphtheria. Among those aware of the disease, only 28 (23.9%) identified germs as causative agents, 26 (22.2%) identified inhalation as a route of transmission, 24 (20.5%) knew diphtheria could cause an epidemic, and 31 (26.5%) identified vaccine as a preventive measure. Most of the respondents (81.2%) had poor knowledge and good perception (68.4%). No statistically significant relationship was observed between sociodemographic variables and Knowledge or perception of Diphtheria.
Conclusion: While the perception of diphtheria was good, knowledge of the disease was poor despite an ongoing outbreak. The Kaduna State government should redouble efforts in community health education and strategic risk communication on diphtheria.
Mendukung konservasi penyu di Pantai Distrik Manokwari Utara melalui program KKN-PPM
Authors: Boli Paulus , Purba Gandi Y. S. , Allo Alberto 
Published: August 2024

ABSTRACT
The problem faced by the society of Mubraidiba Village for a long time has been catching turtles. The caught turtles are used for the family's protein needs and some are sold as family income and are also preserved to be used as wall decorations. This has resulted in the number of turtles decreasing over time. The purpose of the KKN-PPM program is to implement the knowledge that students have in carrying out turtle conservation together with the Manduni Putra Joint Business Group and the community of Mubraidiba village on the coast of North Manokwari District. Implementation of this activity consists of 1) potential mapping and problem identification; 2) preparation of program and activity plans; and 3) program socialization. The program will be implemented for two months (19 June -15 August 2020). The results of the monitoring did not find any turtles landing on Astelin Beach, Mubraidiba Village, so activities continued on Muara Prafi Beach, where quite a lot of turtles were still landing because the environmental conditions were still natural. Egg transfer activities were carried out twice on July 20 and July 22, 2020, with 114 green turtles and 102 olive ridley turtles. Hatching success was 94.2% and hatchling rearing success was 78.4%. The number of hatchlings released into the sea was 80, this activity was a form of outreach to the community of Mubraidiba Village and surrounding villages.
Keywords: Turtle Conservation; Mubraidiba Village; Community Outreach; Egg Relocation; KKN-PPM

ABSTRAK
Permasalahan yang dihadapi masyarakat Kampung Mubraidiba sejak dahulu telah melakukan penangkapan penyu. Penyu yang ditangkap dimanfaatkan untuk kebutuhan protein keluarga dan sebagian dijual sebagai pendapatan keluarga dan juga diawetkan untuk dijadikan hiasan dinding. Hal ini mengakibatkan jumlah penyu mengalami penurunan dari waktu ke waktu. Tujuan program KKN-PPM adalah mengimplementasikan pengetahuan yang dimiliki mahasiswa melakukan konservasi penyu bersama dengan Kelompok Usaha Bersama (KUB) Manduni Putra dan masyarakat Kampung Mubraidiba di pesisir pantai Distrik Manokwari Utara. Pelaksanaan kegiatan ini terdiri dari: 1) pemetaan potensi dan identifikasi masalah; 2) penyusunan rencana program dan kegiatan; 3) sosialisasi program. Pelaksanaan program selama dua bulan (19 Juni -15 Agustus 2020). Hasil monitoring tidak menjumpai penyu yang mendarat di Pantai Astelin Kampung Mubraidiba, sehingga kegiatan dilanjutkan di Pantai Muara Prafi yang masih cukup banyak penyu yang mendarat karena kondisi lingkungan masih alami. Kegiatan pemindahan telur dilakukan 2 kali tanggal 20 Juli dan 22 Juli 2020, penyu hijau sebanyak 114 butir dan penyu lekang 102 butir. Sukses penetesan sebesar 94,2% dan sukses pemeliharaan tukik 78,4%. Jumlah tukik yang dilepas liarkan ke laut sebanyak 80 ekor, kegiatan ini sebagai bentuk sosialisasi kepada masyarakat Kampung Mubraidiba dan kampung sekitarnya.
Kata kunci: Konservasi Penyu; Kampung Mubraidiba; Penyuluhan Masyarakat; Pemindahan Telur; KKN-PPM