bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Glenoid Rim Fracture Following Use of Resorbable Devices for Glenohumeral Stabilization
Authors: Augusti Carlo Alberto , Paladini Paolo , Campi Fabrizio , Merolla Giovanni , Bigoni Marco , Porcellini Giuseppe 
Published: June 2015

Background Resorbable anchors are widely used in arthroscopic stabilization of the shoulder as a means of soft tissue fixation to bone. Their function is to ensure repair stability until they are replaced by host tissue. Complications include inflammatory soft tissue reactions, cyst formation, screw fragmentation in the joint, osteolytic reactions, and enhanced glenoid rim susceptibility to fracture. Purpose To evaluate resorption of biodegradable screws and determine whether they induce formation of areas with poor bone strength that may lead to glenoid rim fracture even with minor trauma. Study Design Case series; Level of evidence, 4. Methods This study evaluated 12 patients with anterior shoulder instability who had undergone arthroscopic stabilization with the Bankart technique and various resorbable anchors and subsequently experienced redislocation. The maximum interval between arthroscopic stabilization and the new dislocation was 52 months (mean, 22.16 months; range, 12-52 months). The mean patient age was 31.6 years (range, 17-61 years). The persistence or resorption of anchor holes; the number, area, and volume of osteolytic lesions; and glenoid erosion/fracture were assessed using computed tomography scans taken after redislocation occurred. Results Complete screw resorption was never documented. Osteolytic lesions were found at all sites (mean diameter, 5.64 mm; mean depth, 8.09 mm; mean area, 0.342 cm2; mean volume, 0.345 cm3), and all exceeded anchor size. Anterior glenoid rim fracture was seen in 9 patients, even without high-energy traumas (75% of all recurrences). Conclusion Arthroscopic stabilization with resorbable devices is a highly reliable procedure that is, however, not devoid of complications. In all 12 patients, none of the different implanted anchors had degraded completely, even in patients with longer follow-up, and all induced formation of osteolytic areas. Such reaction may lead to anterior glenoid rim fracture according to the literature and as found in 75% of the study patients with local osteolysis (9/12). Reducing anchor number and/or size may reduce the risk of osteolytic areas and anterior glenoid rim fracture.
Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results
Authors: Wang Michael L. , Blum Kristie A. , Martin Peter , Goy Andre , Auer Rebecca , Kahl Brad S. , Jurczak Wojciech , Advani Ranjana H. , Romaguera Jorge E. , Williams Michael E. , Barrientos Jacqueline C. , Chmielowska Ewa , Radford John , Stilgenbauer Stephan , Dreyling Martin , Jedrzejczak Wieslaw Wiktor , Johnson Peter , Spurgeon Stephen E. , Zhang Liang , Baher Linda , Cheng Mei , Lee Dana , Beaupre Darrin M. , Rule Simon 
Published: June 2015

Key Points
Ibrutinib demonstrates durable responses and sustained single-agent activity in relapsed or refractory MCL at median 26.7-month follow-up. Ibrutinib shows a favorable benefit-risk profile over time, with a manageable safety profile.
Investigation of Novel Opuntia Ficus-indica Mucilage Nanofiber Membrane Filtration for Water Systems
Authors: Thomas Sylvia W. , Devisetty Manopriya , Katakam Hruday Chand , Perez Samuel , Guo Fei , Stebbins Daniela , Alcantar Norma , Muppaneni Rasudha 
Published: June 2015

ABSTRACTNanofiltration technology is being investigated as a cost-eﬀective and environmentally acceptable mechanism of sustaining industrial and public water systems. Nanofiber membranes are part of the family of filtration devices being used to remove inorganics and organics from water systems. This study investigates the use of the natural material, Opuntia ficus-indica (Ofi) cactus mucilage, as a tool for nanofiber membrane filtration. Mucilage is a natural, non-toxic, bio-compatible, biodegradable, inexpensive and abundant material. Mucilage is a clear colorless substance comprised of proteins, mono-saccharides, and polysaccharides. It also contains organic species, which give it the capacity to interact with metals, cations and biological substances promoting flocculation for removing arsenic, bacteria, E. coli, and other particulates from drinking water. This natural material has the potential to be used as a sustainable method for water filtration and contaminant sensing. Therefore, mucilage nanofiber membranes were electrospun with volume ratios of polyvinyl alcohol (PVA) and polystyrene (PS) to mucilage comparing the interaction of non-polar solvents. Atomic Fluorescence Spectrometry (AFS) from PSAnalytical was used to evaluate electrospun nanofiber membranes made from volume ratios ranging from 30:70 to 70:30 of mucilage: polyvinyl alcohol, mucilage: polystyrene-D-limonene, and mucilage: polystyrene–toluene in different proportions. The mucilage nanofiber membranes were used as filtration devices for 50 ppb arsenic solutions. Arsenic, being a toxic substance, acts as a deadly poison in water systems and has plagued societal preservation for centuries. The total arsenic content in the samples were measured before and after treatment. Comparative tests were also performed using 1) coated and non-coated GVWP 0.22 µm and 0.45 µm filters from Millipore and 2) columnar flow through Pasteur glass pipets filled with 0.5 g of pre-washed sand from Fisher Scientific and 0.01 g of mucilage nanofibers. Results show mucilage: polystyrene nanofiber membrane filters were capable of removing arsenic from test solutions, in terms of the percentage of arsenic removed. These data elucidate that mucilage nanofiber membranes have the potential to serve as the basis for the next generation of economically sustainable filtration devices that make use of a natural non-toxic material for sustainable water systems.
Comparative testing of crack formation in strain-hardening cement-based composites (SHCC)
Authors: van Zijl Gideon P. A. G. , Slowik Volker , Toledo Filho Romildo D. , Wittmann Folker H. , Mihashi Hirozo 
Published: June 2015

Abstract
Two of the main activities of RILEM Technical Committee 208-HFC Subcommittee 2 were the preparation and publication of the state-of-the-art report on durability of strain hardening cement-based composites (SHCC), and the performance of comparative laboratory testing on SHCC. In this paper the comparative mechanical tests are reported, as performed in laboratories of five participating institutions. The purpose was to investigate and compare the crack patterns in terms of crack widths and spacing, and subsequently to make recommendations for a suitable test setup and procedure towards characterizing cracking in this class of materials. Such standardized procedures are required for future systematic and objective research towards durability of these materials in their in-service conditions, i.e. their resistance to deterioration processes in the cracked state. Standardized test procedures are also required for durability testing and guidelines for structural design with SHCC, which is the focus of follow-up committee activity in TC 240-FDS.
Epidermal Growth Factor Receptor (EGFR)-Tyrosine Kinase Inhibitor Treatment and Salvage Chemotherapy in EGFR-Mutated Elderly Pulmonary Adenocarcinoma Patients
Authors: Tseng Yen-Han , Tseng Yen-Chiang , Lin Yi-hsuan , Lee Yu-Chin , Perng Reury-Perng , Whang-Peng Jacqueline , Chen Yuh-Min 
Published: June 2015

Abstract

Background.
Lung cancer is frequently a disease of elderly patients. However, these patients are often treated less actively owing to a higher comorbidity rate and poor performance status. The efficacy of different treatments in elderly patients with epidermal growth factor receptor (EGFR)-mutated lung cancer is still unknown.

Materials and Methods.
We retrospectively reviewed the records of our pulmonary adenocarcinoma patients treated between 2010 and 2013. Data on patient age, type of tumor EGFR mutation, response to first-line EGFR-tyrosine kinase inhibitor (TKI) treatment, type of salvage chemotherapy, and efficacy of EGFR-TKI and salvage chemotherapy were collected.

Results.
In all, 473 of 1,230 stage IV adenocarcinoma patients had an EGFR mutation, and 330 of them received first-line TKI treatment. Of the 330 patients, 160 were ≥70 years old (elderly group) and 170 were &lt;70 years old (younger group). The response rate and progression-free survival (PFS) with first-line TKI treatment were not significantly different. The elderly group had shorter median survival. A total of 107 patients received salvage chemotherapy after first-line EGFR-TKI treatment: 45 in the elderly group and 62 in the younger group. Their response rate and PFS were not significantly different; however, the younger group had longer median survival. Additional subgroup analysis showed that younger patients who received platinum-based chemotherapy or combination chemotherapy had better median survival than did the elderly patients. The PFS was longer among younger patients receiving a platinum-based regimen than that among the elderly patients.

Conclusion.
Elderly patients with disease progression after first-line EGFR-TKI treatment can receive chemotherapy and have a response rate similar to that of younger patients.

Implications for Practice:
The aim of the present study was to investigate the efficacy of first-line epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment in elderly patients and the outcomes of subsequent salvage chemotherapy after disease progression. The most important finding was that elderly patients with disease progression after first-line EGFR-TKI treatment can receive salvage chemotherapy and have a response rate similar to that of younger patients who received salvage chemotherapy.
Within‐Boll Yield Characteristics and Their Correlation with Fiber Quality Parameters following Mutagenesis of Upland Cotton, TAM 94L‐25
Authors: Brown Nino , Smith C. Wayne , Hague Steve , Auld Dick , Hequet Eric , Joy Kolbyn , Jones Don 
Published: June 2015

ABSTRACTLimited genetic diversity could be contributing to the limited genetic gains in upland cotton, Gossypium hirsutum L., fiber lengths and strengths. Smith and Coyle (1997) reported negative associations between many fiber quality traits and the number of fibers per unit surface area of seed (FSSA), the most basic lint yield component. The objective of this study was to determine if mutagenesis could be used to modify the associations of within‐boll yield components and fiber quality parameters. TAM 94L‐25 (Smith, 2003) (PI 631440) seeds were treated with 3% v/v ethyl methanesulfonate (EMS). Twelve TAM 94L‐25 M4:6 mutant (M) lines, ‘FiberMax FM 832’ (Constable et al., 2001) (PVP 9800258; PI 603955) and ‘Phytogen PSC 355’ (PI 612974), and the unmutated parent TAM 94L‐25 were grown in performance trials in 2008 and 2009. The data suggests EMS‐based mutagenesis was successful in producing variation for within‐boll yield characteristics as well as fiber quality. Whether or not linkages or pleiotropic effects were disrupted is equivocal, with some correlation values significantly different between the control cultivars and the M lines. Mutant lines M2, M3, M50, and M51 were identified with improved FSSA. Ethyl methanesulfonate–based mutagenesis could be a valuable additional tool to create selectable variation in cotton for basic lint yield components and to break linkages of basic yield components and fiber quality.
Evaluation of Work Stress, Turnover Intention, Work Experience, and Satisfaction With Preceptors of New Graduate Nurses Using a 10-Minute Preceptor Model
Authors: Hu Yi-Chun , Chen Su-Ru , Chen I-Hui , Shen Hsi-Che , Lin Yen-Kuang , Chang Wen-Yin 
Published: June 2015

Background:Preparing new graduate nurses (NGNs) to achieve standards of nursing competence is challenging; therefore, this study developed and evaluated the effects of a 10-minute preceptor (10MP) model for assisting NGNs in their professional development and increasing their retention in hospitals.Method:A repeated-measures design study, with an intervention and a two-group comparison, was conducted. A total of 107 NGNs participated in the study. At day 7, work stress and work experience were moderately high for the NGNs in both the 10MP and traditional preceptor model (TPM) groups.Results:The preceptorship program showed significant differences between groups (p= 0.001) regarding work stress at months 2 and 3 and work experience at months 1, 2, and 3. The 10MP group reported lower turnover intention and higher satisfaction with the preceptors than the TPM group.Conclusion:The 10MP model is effective at improving training outcomes and facilitating the professional development of NGNs.J Contin Educ Nurs.2015;46(6):261–271.
Mentoring Hispanic Undergraduate and Graduate Research Assistants: Building Research Capacity in Nursing
Authors: Aponte Judith , Figueroa Brenda N. , Madera Melody , Campos-Dominguez Giselle , Panora Elizabeth , Jaramillo Diana 
Published: June 2015

Background:
This article discusses and describes the experiences of five Hispanic bilingual (English and Spanish) research assistants (RAs) who were undergraduate and graduate nursing students and who were part of a research team.

Method:
A capacity-building framework was used, which has six guiding principles: a whole-system approach; accommodating diversity; reducing barriers to participation; enabling collaboration; mentoring; and facilitating networking. In addition, mentorship and peer learning were essential components of building research capacity.

Results:
Reflections of the five RAs highlighting how these principles were applied are described. The experiences of the five Hispanic RAs and the outcomes of the projects are also described.

Conclusion:

These experiences demonstrate the importance of involving undergraduate and graduate nursing students in research, which can build research capacity and increase the number of Hispanic nurses in the workforce. [
J Nurs Educ.
2015;54(6):328–334.]
Faculty to Faculty: Advice for Educators New to Teaching in Accelerated Second Baccalaureate Degree Nursing Programs
Authors: Boellaard Melissa R. , Brandt Cheryl L. , Zorn CeCelia R. 
Published: June 2015

Background:
Despite a growing faculty shortage, accelerated second baccalaureate degree nursing programs (ASBSN) proliferate. To prepare faculty for this teaching role, guide their development, and enhance recruitment and retention, ASBSN faculty in this descriptive study offered advice to new ASBSN educators.

Method:

Data were collected online from ASBSN faculty (
N
= 93) across the midwestern United States.

Results:
Six themes emerged: (a) Plan for Program Intensity That Stresses Students and Faculty, (b) Be Available, Flexible, Open-Minded, and Patient, (c) Uphold Early-Established Expectations and Rigorous Standards, (d) Be Prepared for Challenging Questions: Know Your Material and Be Organized, (e) Integrate Students’ Diversity Into Teaching and Learning, and (f) Adapt Content and Teaching Strategies to Align With Student and Program Characteristics. Consistency with the Suplee and Gardner new faculty orientation model was explored.

Conclusion:

Respondents viewed new ASBSN faculty as active agents who can influence their own effectiveness and success. [
J Nurs Educ.
2015;54(6):343–346.]
Using Wikis to Stimulate Collaborative Learning in Two Online Health Sciences Courses
Authors: Zitzelsberger Hilde , Campbell Karen A. , Service Dorothea , Sanchez Otto 
Published: June 2015

Background:
The use of wiki technology fits well in courses that encourage constructive knowledge building and social learning by a community of learners. Pedagogically, wikis have attracted interest in higher education environments because they facilitate the collaborative processes required for developing student group assignments.

Method:
This article describes a pilot project to assess the implementation of wikis in two online small- and mid-sized elective courses comprising nursing students in third- or fourth-year undergraduate levels within interdisciplinary health sciences courses.

Results:
The need exists to further develop the pedagogical use of wiki environments before they can be expected to support collaboration among undergraduate nursing students.

Conclusion:

Adapting wiki implementation to suitable well-matched courses will make adaptation of wikis into nursing curricula more effective and may increase the chances that nursing students will hone the collaborative abilities that are essential in their future professional roles in communities of practice. [
J Nurs Educ
. 2015;54(6):352–355.]
Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses
Authors: Law Mankit , Lee YongChan , Morales J. Luis , Ning Gang , Huang Weishan , Pabon Jonathan , Kannan Arun K. , Jeong Ah-Reum , Wood Amie , Carter Chavez , Mohinta Sonia , Song Jihong , August Avery 
Published: June 2015

Abstract
Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx into cells has been suggested. We have previously identified the actin reorganizing protein Drebrin as a target of the immunosuppressant 3,5-bistrifluoromethyl pyrazole, which inhibits calcium influx into cells. In this study, we show that Drebrin−/− mice exhibit reduced IgE-mediated histamine release and passive systemic anaphylaxis, and Drebrin−/− mast cells also exhibit defects in FcεRI-mediated degranulation. Drebrin−/− mast cells exhibit defects in actin cytoskeleton organization and calcium responses downstream of the FcεRI, and agents that relieve actin reorganization rescue mast cell FcεRI-induced degranulation. Our results indicate that Drebrin regulates the actin cytoskeleton and calcium responses in mast cells, thus regulating mast cell function in vivo.
Retrieval of aerosol microphysical properties from AERONET photopolarimetric measurements: 2. A new research algorithm and case demonstration
Authors: Xu Xiaoguang , Wang Jun , Zeng Jing , Spurr Robert , Liu Xiong , Dubovik Oleg , Li Li , Li Zhengqiang , Mishchenko Michael I. , Siniuk Aliaksandr , Holben Brent N. 
Published: June 2015

AbstractA new research algorithm is presented here as the second part of a two‐part study to retrieve aerosol microphysical properties from the multispectral and multiangular photopolarimetric measurements taken by Aerosol Robotic Network's (AERONET's) new‐generation Sun photometer. The algorithm uses an advanced UNified and Linearized Vector Radiative Transfer Model and incorporates a statistical optimization approach. While the new algorithm has heritage from AERONET operational inversion algorithm in constraining a priori and retrieval smoothness, it has two new features. First, the new algorithm retrieves the effective radius, effective variance, and total volume of aerosols associated with a continuous bimodal particle size distribution (PSD) function, while the AERONET operational algorithm retrieves aerosol volume over 22 size bins. Second, our algorithm retrieves complex refractive indices for both fine and coarse modes, while the AERONET operational algorithm assumes a size‐independent aerosol refractive index. Mode‐resolved refractive indices can improve the estimate of the single‐scattering albedo (SSA) for each aerosol mode and thus facilitate the validation of satellite products and chemistry transport models. We applied the algorithm to a suite of real cases over Beijing_RADI site and found that our retrievals are overall consistent with AERONET operational inversions but can offer mode‐resolved refractive index and SSA with acceptable accuracy for the aerosol composed by spherical particles. Along with the retrieval using both radiance and polarization, we also performed radiance‐only retrieval to demonstrate the improvements by adding polarization in the inversion. Contrast analysis indicates that with polarization, retrieval error can be reduced by over 50% in PSD parameters, 10–30% in the refractive index, and 10–40% in SSA, which is consistent with theoretical analysis presented in the companion paper of this two‐part study.
Quantization Effect on Sliding Mode Control of Uncertain Dynamical Systems
Authors: Yan Yan , Yu Xinghuo , Sun Changyin 
Published: June 2015

AbstractThis paper studies the quantization effect on dynamical behaviors of the sliding mode control system with matched uncertainties and disturbances. The sufficient condition for stability of the system is given. The performance of both the sliding mode and the system trajectories with quantized state feedback are discussed. We show that the sliding mode with quantization is piecewise constant and the trajectory chatters in the boundary layer of the designed sliding manifold with thickness O(μ), where μ is the quantization level. Simulation results are presented to show the effectiveness of the theoretical results.
Bioinspired production of magnetic laccase‐biotitania particles for the removal of endocrine disrupting chemicals
Authors: Ardao Inés , Magnin Delphine , Agathos Spiros N. 
Published: June 2015

ABSTRACTMicrobial laccases are powerful enzymes capable of degrading lignin and other recalcitrant compounds including endocrine disrupting chemicals (EDCs). Efficient EDC removal on an industrial scale requires robust, stable, easy to handle and cost‐effective immobilized biocatalysts. In this direction, magnetic biocatalysts are attractive due to their easy separation through an external magnetic field. Recently, a bioinspired immobilization technique that mimics the natural biomineralization reactions in diatoms has emerged as a fast and versatile tool for generating robust, cheap, and highly stable (nano) biocatalysts. In this work, bioinspired formation of a biotitania matrix is triggered on the surface of magnetic particles in the presence of laccase in order to produce laccase‐biotitania (lac‐bioTiO2) biocatalysts suitable for environmental applications using a novel, fast and versatile enzyme entrapment technique. Highly active lac‐bioTiO2 particles have been produced and the effect of different parameters (enzyme loading, titania precursor concentration, pH, duration of the biotitania formation, and laccase adsorption steps) on the apparent activity yield of these biocatalysts were evaluated, the concentration of the titania precursor being the most influential. The lac‐bioTiO2 particles were able to catalyze the removal of bisphenol A, 17α‐ethinylestradiol and diclofenac in a mixture of six model EDCs and retained 90% of activity after five reaction cycles and 60% after 10 cycles. Biotechnol. Bioeng. 2015;112: 1986–1996. © 2015 Wiley Periodicals, Inc.