bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Genome Sequence of Terribacillus aidingensis Strain MP602, a Moderately Halophilic Bacterium Isolated from Cryptomeria fortunei in Tianmu Mountain in China
Authors: Lu Peng , Lei Mengying , Xiao Fenghu , Zhang Liqin , Wang Yongjun 
Published: March 2015

ABSTRACT

Terribacillus aidingensis
strain MP602, which was isolated from an ancient tree (Cryptomeria forunei) in Tianmu Mountain in China, has antagonistic activity against several certain phytopathogenic fungi. Here, we report the genome sequence of this strain. This is the first complete genome report of the Terribacillus genus.
Complete Genome Sequence of Halophilic Yeast
Meyerozyma caribbica
MG20W Isolated from Rhizosphere Soil
Authors: Kim Jong-Shik , Baek Jeong-Hoon , Park Nyun-Ho , Kim Changhoon 
Published: March 2015

ABSTRACT
Meyerozyma caribbica MG20W was originally isolated from rhizosphere soil on reclaimed land in the Republic of Korea. We describe herein the 10.64-Mbp-long genome sequence of M. caribbica MG20W, which exhibits high salt resistance.
Draft Genome Sequence of the Polychlorinated Biphenyl-Degrading Bacterium Cupriavidus basilensis KF708 (NBRC 110671) Isolated from Biphenyl-Contaminated Soil
Authors: Suenaga Hikaru , Yamazoe Atsushi , Hosoyama Akira , Kimura Nobutada , Hirose Jun , Watanabe Takahito , Fujihara Hidehiko , Futagami Taiki , Goto Masatoshi , Furukawa Kensuke 
Published: March 2015

ABSTRACT

We report the draft genome sequence of
Cupriavidus basilensis
KF708 (NBRC 110671), which utilizes biphenyl as a sole carbon source and degrades polychlorinated biphenyls (PCBs). The KF708 strain possesses genes for biphenyl catabolism and other genes involved in various aromatic compounds.
Draft Genome Sequence of Xanthomonas sacchari Strain LMG 476
Authors: Pieretti Isabelle , Bolot Stéphanie , Carrère Sébastien , Barbe Valérie , Cociancich Stéphane , Rott Philippe , Royer Monique 
Published: March 2015

ABSTRACT

We report the high-quality draft genome sequence of
Xanthomonas sacchari
strain LMG 476, isolated from sugarcane. The genome comparison of this strain with a previously sequenced X. sacchari strain isolated from a distinct environmental source should provide further insights into the adaptation of this species to different habitats and its evolution.
Cognitive dysfunction in adolescents with chronic fatigue: a cross-sectional study
Authors: Sulheim Dag , Fagermoen Even , Sivertsen Øyvind Stople , Winger Anette , Wyller Vegard Bruun , Øie Merete Glenne 
Published: March 2015

ObjectiveTo compare cognitive function in adolescents with chronic fatigue with cognitive function in healthy controls (HC).Study designCross-sectional study.SettingPaediatric department at Oslo University Hospital, Norway.Participants120 adolescents with chronic fatigue (average age 15.4 years; range 12–18) and 39 HC (average age 15.2 years; range 12–18).MethodsThe adolescents completed a neurocognitive test battery measuring processing speed, working memory, cognitive inhibition, cognitive flexibility, verbal learning and verbal memory, and questionnaires addressing demographic data, depression symptoms, anxiety traits, fatigue and sleep problems. Parents completed the Behaviour Rating Inventory of Executive Function (BRIEF), which measures the everyday executive functions of children.ResultsAdolescents with chronic fatigue had impaired cognitive function compared to HC regarding processing speed (mean difference 3.3, 95% CI 1.1 to 5.5, p=0.003), working memory (−2.4, −3.7 to −1.1, p<0.001), cognitive inhibition response time (6.2, 0.8 to 11.7, p=0.025) and verbal learning (−1.7, −3.2 to −0.3, p=0.022). The BRIEF results indicated that everyday executive functions were significantly worse in the chronic fatigue group compared to the HC (11.2, 8.2 to 14.3, p<0.001). Group differences remained largely unaffected when adjusted for symptoms of depression, anxiety traits and sleep problems.ConclusionsAdolescents with chronic fatigue had impaired cognitive function of clinical relevance, measured by objective cognitive tests, in comparison to HC. Working memory and processing speed may represent core difficulties.
What makes for a ‘good’ or ‘bad’ paediatric diabetes service from the viewpoint of children, young people, carers and clinicians? A synthesis of qualitative findings
Authors: Curtis-Tyler Katherine , Arai Lisa , Stephenson Terence , Roberts Helen 
Published: March 2015

BackgroundThere is mounting evidence that experience of care is a crucial part of the pathway for successful management of long-term conditions.Design and objectivesTo carry out (1) a systematic mapping of qualitative evidence to inform selection of studies for the second stage of the review; and (2) a narrative synthesis addressing the question, What makes for a ‘good’ or a ‘bad’ paediatric diabetes service from the viewpoint of children, young people, carers and clinicians?ResultsThe initial mapping identified 38 papers. From these, the findings of 20 diabetes-focused papers on the views on care of ≥650 children, parents and clinicians were synthesised. Only five studies included children under 11 years. Children and young people across all age groups valued positive, non-judgemental and relationship-based care that engaged with their social, as well as physical, health. Parents valued provision responsive to the circumstances of family life and coordinated across services. Clinicians wanting to engage with families beyond a child's immediate physical health described finding this hard to achieve in practice.LimitationsSocioeconomic status and ethnicity were poorly reported in the included studies.ConclusionsIn dealing with diabetes, and engaging with social health in a way valued by children, parents and clinicians, not only structural change, such as more time for consultation, but new skills for reworking relations in the consultation may be required.
The trumpet player with a swelling in the neck
Authors: Edmiston Rachel , Hariri Ahmad , Karagama Yakubu 
Published: March 2015

Bilateral neck swelling in patients following valsalva manouveres could lead to a diagnosis of either a pharyngocele or laryngocele. Distinguishing between them can be complicated but is vital given the possibility for an acute airway in patients with laryngoceles.A 20-year-old trumpet player presents with a 5-year history of neck swelling. Clinical suspicion is that of a pharyngocele but imaging introduces some confusion with the diagnosis.Both pharyngoceles and laryngoceles can occur as a result of prolonged positive pressure. Accurate assessment with fibreoptic examination and imaging is needed to confirm the diagnosis.Pharyngoceles are often misdiagnosed as laryngoceles. Though treatment is similar between the two patient groups it is vital that a distinction is made to enable careful observation of the airway in patients with laryngoceles.
Race/ethnicity and the risk of childhood leukaemia: a case–control study in California
Authors: Oksuzyan Sona , Crespi Catherine M , Cockburn Myles , Mezei Gabor , Vergara Ximena , Kheifets Leeka 
Published: March 2015

BackgroundWe conducted a large registry-based study in California to investigate the association between race/ethnicity and childhood leukaemia focusing on two subtypes: acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML).MethodsWe obtained information on 5788 cases and 5788 controls by linking California cancer and birth registries. We evaluated relative risk of childhood leukaemia by race and ethnicity of the child and their parents using conditional logistic regression, with adjustment for potential confounders.ResultsCompared with Whites, Black children had lower risk of ALL (OR=0.54, 95% CI 0.45 to 0.66) as well as children of Black/Asian parents (OR=0.31, 95% CI 0.10 to 0.94). Asian race was associated with increased risk of AML with OR=1.643, 95% CI 1.10 to 2.46 for Asian vs Whites; and OR=1.67, 95% CI 1.04 to 2.70 for Asian/Asian vs White/White. Hispanic ethnicity was associated with increased risk of ALL (OR=1.37, 95% CI 1.22 to 1.52). A gradient in risk of ALL was observed while comparing Hispanic children with both parents Hispanic, one parent Hispanic and non-Hispanic children (p Value for trend <0.0001). The highest risk of ALL was observed for children with a combination of Hispanic ethnicity and White race compared with non-Hispanic whites (OR=1.27, 95% CI 1.12 to 1.44). The lowest risk was observed for non-Hispanic blacks (OR=0.46, 95% CI 0.36 to 0.60). Associations for total childhood leukaemia were similar to ALL.ConclusionsOur results confirm that there are ethnic and racial differences in the incidence of childhood leukaemia. These differences indicate that some genetic and/or environmental/cultural factors are involved in aetiology of childhood leukaemia.
Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma
Authors: Mohan Shalini V. , Chang Anne Lynn S. 
Published: March 2015

Abstract
Smoothened inhibitors represent the first class of targeted drugs approved for use in advanced and metastatic basal cell carcinoma. For many patients with limited treatment options, this drug class has led to significant clinical improvements, but is not without side effects. In this review, we outline the basic mechanism of smoothened inhibitors and the most commonly observed cutaneous and extracutaneous side effects. We also highlight possible mechanisms for these adverse events and current management strategies. Clin Cancer Res; 21(12); 2677–83. ©2015 AACR.
Gap Junction Coupling Is Required for Tumor Cell Migration Through Lymphatic Endothelium
Authors: Karpinich Natalie O. , Caron Kathleen M. 
Published: March 2015

Objective—
The lymphatic vasculature is a well-established conduit for metastasis, but the mechanisms by which tumor cells interact with lymphatic endothelial cells (LECs) to facilitate escape remain poorly understood. Elevated levels of the lymphangiogenic peptide adrenomedullin are found in many tumors, and we previously characterized that its expression is necessary for lymphatic vessel growth within both tumors and sentinel lymph nodes and for distant metastasis.

Approach and Results—

This study used a tumor cell-LEC coculture system to identify a series of adrenomedullin-induced events that facilitated transendothelial migration of the tumor cells through a lymphatic monolayer. High levels of adrenomedullin expression enhanced adhesion of tumor cells to LECs, and further analysis revealed that adrenomedullin promoted gap junction coupling between LECs as evidenced by spread of Lucifer yellow dye. Adrenomedullin also enhanced heterocellular gap junction coupling as demonstrated by Calcein dye transfer from tumor cells into LECs. This connexin-mediated gap junction intercellular communication was necessary for tumor cells to undergo transendothelial migration because pharmacological blockade of this heterocellular communication prevented the ability of tumor cells to transmigrate through the lymphatic monolayer. In addition, treatment of LECs with adrenomedullin caused nuclear translocation of β-catenin, a component of endothelial cell junctions, causing an increase in transcription of the downstream target gene
C-MYC
. Importantly, blockade of gap junction intercellular communication prevented β-catenin nuclear translocation.

Conclusions—
Our findings indicate that maintenance of cell–cell communication is necessary to facilitate a cascade of events that lead to tumor cell migration through the lymphatic endothelium.
Inspiratory Resistance Improves Postural Tachycardia
Authors: Gamboa Alfredo , Paranjape Sachin Y. , Black Bonnie K. , Arnold Amy C. , Figueroa Rocío , Okamoto Luis E. , Nwazue Victor C. , Diedrich Andre , Plummer W. Dale , Dupont William D. , Robertson David , Raj Satish R. 
Published: March 2015

Background—
The objective of this study was to determine the effect of inspiratory resistance through an impedance threshold device (ITD) on orthostatic tolerance in patients with postural tachycardia syndrome. We hypothesized that the ITD would result in a greater negative intrathoracic pressure to enhance cardiac venous return, improve stroke volume, and reduce heart rate in these patients.

Methods and Results—

We compared the effect of a sham device (sham, no resistance) versus an ITD (increased inspiratory resistance) in 26 patients with postural tachycardia syndrome in a randomized, single-blind, crossover study. Hemodynamic assessments were performed at baseline while supine and during head-up tilt to 70° for 10 minutes. We did not find differences in baseline hemodynamic parameters between the ITD and the sham devices. After 10 minutes of head-up tilt, the heart rate was lower with the ITD versus sham device (102±4 versus 109±4 beat/min, respectively;
P
=0.003). The ITD also improved stroke volume compared with the sham device (35±2 versus 26±1 mL;
P
=0.006).

Conclusions—
These findings suggest that increasing negative intrathoracic pressure with ITD breathing improves heart rate control in patients with postural tachycardia syndrome during upright posture.

Clinical Trial Registration—

clinicaltrials.gov
; Unique Identifier: NCT00962728.
Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States
Authors: Magnani Giulia , Bonaca Marc P. , Braunwald Eugene , Dalby Anthony J. , Fox Keith A. A. , Murphy Sabina A. , Nicolau José Carlos , Oude Ophuis Ton , Scirica Benjamin M. , Spinar Jindrich , Theroux Pierre , Morrow David A. 
Published: March 2015

Background
Vorapaxar is a protease‐activated receptor‐1 antagonist approved by the U.S. Food and Drug Administration (FDA) for the reduction of thrombotic cardiovascular (CV) events in patients with a history of myocardial infarction (MI) and peripheral artery disease (PAD), without a previous stroke or transient ischemic attack (TIA).

Methods and Results

We examined the efficacy and safety of vorapaxar in the intended use population, considering 20 170 patients randomized in the multinational, double‐blinded, placebo‐controlled TRA 2°P‐TIMI 50 trial. Of these, 16 897 qualified with a history of MI in the prior 2 weeks to 1 year and 3273 with PAD. At baseline 97% of the patients were treated with aspirin, 71% with a thienopyridine, and 93% a statin. At 3 years, the endpoint of CV death, MI, or stroke was significantly reduced with vorapaxar compared with placebo (7.9% versus 9.5%, HR, 0.80; 95% CI 0.73 to 0.89;
P
<0.001). Vorapaxar also significantly reduced the composite of CV death, MI, stroke, and urgent coronary revascularization (10.1% versus 11.8%, HR, 0.83; 95% CI 0.76 to 0.90;
P
<0.001), as well as the rate of CV death or MI (
P
<0.001). The safety endpoint of GUSTO moderate or severe bleeding, was increased in the vorapaxar group (3.7 versus 2.4, HR, 1.55; 95% CI 1.30 to 1.86,
P
<0.001). Intracranial bleeding (ICH) was 0.6% versus 0.4%,
P
=0.10 with vorapaxar versus placebo, with fatal bleeding 0.2% versus 0.2%;
P
=0.70.

Conclusions
In patients with prior MI or PAD who have not had a previous stroke or TIA, vorapaxar added to standard therapy is effective for long‐term secondary prevention of thrombotic CV events, while increasing moderate or severe bleeding.

Clinical Trial Registration
URL: clinicaltrials.gov Unique Identifier: NCT00526474.
Three‐Dimensional Echocardiography and 2D‐3D Speckle‐Tracking Imaging in Chronic Pulmonary Hypertension: Diagnostic Accuracy in Detecting Hemodynamic Signs of Right Ventricular (RV) Failure
Authors: Vitarelli Antonio , Mangieri Enrico , Terzano Claudio , Gaudio Carlo , Salsano Felice , Rosato Edoardo , Capotosto Lidia , D'Orazio Simona , Azzano Alessia , Truscelli Giovanni , Cocco Nino , Ashurov Rasul 
Published: March 2015

Background

Our aim was to compare three‐dimensional (3D) and 2D and 3D speckle‐tracking (2D‐
STE
, 3D‐
STE
) echocardiographic parameters with conventional right ventricular (
RV
) indexes in patients with chronic pulmonary hypertension (
PH
), and investigate whether these techniques could result in better correlation with hemodynamic variables indicative of heart failure.

Methods and Results

Seventy‐three adult patients (mean age, 53±13 years; 44% male) with chronic
PH
of different etiologies were studied by echocardiography and cardiac catheterization (25 precapillary
PH
from pulmonary arterial hypertension, 23 obstructive pulmonary heart disease, and 23 postcapillary
PH
from mitral regurgitation). Thirty healthy subjects (mean age, 54±15 years; 43% male) served as controls. Standard 2D measurements (
RV
–fractional area change–tricuspid annular plane systolic excursion) and mitral and tricuspid tissue Doppler annular velocities were obtained. RV 3D volumes and global and regional ejection fraction (3D‐
RVEF
) were determined.
RV
strains were calculated by 2D‐
STE
and 3D‐
STE
.
RV
3D global‐free‐wall longitudinal strain (3D
GFW
‐
RVLS
), 2D global‐free‐wall longitudinal strain (
GFW
‐
RVLS
), apical‐free‐wall longitudinal strain, basal‐free‐wall longitudinal strain, and 3D‐
RVEF
were lower in patients with precapillary
PH
(
P
<0.0001) and postcapillary
PH
(
P
<0.01) compared to controls. 3D
GFW
‐
RVLS
(hazard ratio 4.6, 95%
CI
2.79 to 8.38,
P
=0.004) and 3D‐
RVEF
(hazard ratio 5.3, 95%
CI
2.85 to 9.89,
P
=0.002) were independent predictors of mortality. Receiver operating characteristic curves showed that the thresholds offering an adequate compromise between sensitivity and specificity for detecting hemodynamic signs of
RV
failure were 39% for 3D‐
RVEF
(
AUC
0.89), −17% for 3D
GFW
‐
RVLS
(
AUC
0.88), −18% for
GFW
‐
RVLS
(
AUC
0.88), −16% for apical‐free‐wall longitudinal strain (
AUC
0.85), 16 mm for tricuspid annular plane systolic excursion (
AUC
0.67), and 38% for
RV
‐
FAC
(
AUC
0.62).

Conclusions

In chronic
PH
, 3D, 2D‐
STE
and 3D‐
STE
parameters indicate global and regional
RV
dysfunction that is associated with
RV
failure hemodynamics better than conventional echo indices.
Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes
Authors: Schulz Gerald B. , Wieland Elfriede , Wüstehube-Lausch Joycelyn , Boulday Gwénola , Moll Iris , Tournier-Lasserve Elisabeth , Fischer Andreas 
Published: March 2015

Background and Purpose—

Cerebral cavernous malformation (CCM) is a neurovascular dysplasia characterized by conglomerates of enlarged endothelial channels in the central nervous system, which are almost devoid of pericytes or smooth muscle cells. This disease is caused by loss-of-function mutations in
CCM1
,
CCM2
, or
CCM3
genes in endothelial cells, making blood vessels highly susceptible to angiogenic stimuli.
CCM1
- and
CCM3
-silenced endothelial cells have a reduced expression of the Notch ligand Delta-like 4 (DLL4) resulting in impaired Notch signaling and irregular sprouting angiogenesis. This study aimed to address if DLL4, which is exclusively expressed on endothelial cells, may influence interactions of endothelial cells with pericytes, which express Notch3 as the predominant Notch receptor.

Methods—
Genetic manipulation of primary human endothelial cells and brain pericytes. Transgenic mouse models were also used.

Results—

Endothelial cell–specific ablation of
Ccm1
and
Ccm2
in different mouse models led to the formation of CCM-like lesions, which were poorly covered by periendothelial cells. CCM1 silencing in endothelial cells caused decreased Notch3 activity in cocultured pericytes. DLL4 proteins stimulated Notch3 receptors on human brain pericytes. Active Notch3 induced expression of
PDGFRB2, N-Cadherin
,
HBEGF
,
TGFB1, NG2
, and
S1P
genes. Notch3 signaling in pericytes enhanced the adhesion strength of pericytes to endothelial cells, limited their migratory and invasive behavior, and enhanced their antiangiogenic function. Pericytes silenced for Notch3 expression were more motile and could not efficiently repress angiogenesis.

Conclusions—
The data suggest that Notch signaling in pericytes is important to maintain the quiescent vascular phenotype. Deregulated Notch signaling may, therefore, contribute to the pathogenesis of CCM.
Attention Deficits After Aneurysmal Subarachnoid Hemorrhage Measured Using the Test of Variables of Attention
Authors: Wallmark Svante , Lundström Erik , Wikström Johan , Ronne-Engström Elisabeth 
Published: March 2015

Background and Purpose—
The aim of this pilot study was to assess attention deficits in patients with aneurysmal subarachnoid hemorrhage using the test of variables of attention (TOVA). This is a computer-based continuous performance test providing objective measures of attention. We also compared the TOVA results with the attention and concentration domains of Montgomery Åsberg Depression Rating Scale and Montreal cognitive assessment, 2 examiner-administrated neuropsychological instruments.

Methods—
Nineteen patients with moderate to good recovery (Glasgow outcome scale, 4–5) were assessed using the TOVA, Montgomery Åsberg Depression Rating Scale, and Montreal cognitive assessment. The measurements were done when the patients visited the hospital for a routine magnetic resonance imaging control of the aneurysm.

Results—
TOVA performance was pathological in 58%. The dominating pattern was a worsening of performance in the second half of the test, commonly a failing to react to correct stimuli. We found no correlation between TOVA and the performance in concentration and attention domains of Montgomery Åsberg Depression Rating Scale and Montreal cognitive assessment.

Conclusions—
Attention deficits, measured by the TOVA, were common after subarachnoid hemorrhage. This should be further studied to improve outcome.
The Distributed Cognitive Economics of Reform: A Framework
Authors: Lieber André 
Published: March 2015

We present an enriched cognitive approach to the political economy of reform based on the notion of distributed cognition. Our aim is to describe the origination causation of economic reforms highlighting the interactions between people, artefacts as well as internal and external representations. In particular, we ask how reformers are able to turn a cognitively ill-defined situation into a cognitively well-defined situation. The proposed framework, we tentatively call ‘the distributed cognitive economics of reform’, emphasizes three key messages: First, economic reforms are creative processes largely driven by self-organized innovation and acts of public entrepreneurship. Second, the cognitive distance between individuals both enables and constraints cooperation and, most importantly, learning. Third, reformers’ ability to communicate to a wide range of audiences is crucial in times of reform. In consequence, successful reformers often rely on policy metaphors as primary means to manage high levels of uncertainty, complexity and ambiguity. Presenting post-1978 Chinese economic reform as a case study, we argue that the notion of distributed cognition can improve our understanding of economic reform processes. JEL: B41, B52, P41, Z18