bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary aldosteronism: An underdiagnosed clinical entity
Authors: Jain Peeyush , Kaushik Atul , Dey Nilashish , Mehta Ashwani , Kapoor Shaloo , Agrawal Chhavi 
Published: August 2024

Abstract
Primary aldosteronism (PA) is a group of disorders characterized by excessive and autonomous aldosterone secretion by one or both adrenal glands leading to hypertension. Thought to be rare, 5%–13% of the hypertensive patients are found to have PA by systematic screening. There is also a long delay in diagnosis, which may account for high rates of the long-term complications. PA is most commonly caused by bilateral adrenal hyperplasia, followed by an aldosterone-producing adrenal adenoma. Aldosterone-producing adrenal cortical lesions are due to the mutations in various genes encoding membrane-bound ion channels. Some forms of the familial hyperaldosteronism have also been linked to germline mutations. Inappropriate secretion of aldosterone results in hypertension, hypokalemia, and metabolic alkalosis. Hypokalemia is not a must for considering the diagnosis. It is important to detect PA because not only it is a potentially curable cause of hypertension but also patients with PA have a higher prevalence of cardiovascular morbidity and mortality compared with essential hypertension. This article is an account of screening, confirmation, and management strategies of this underdiagnosed clinical entity for the practicing clinicians.
Primary transitional cell carcinoma of the endometrium: Case report of a rare tumor
Authors: Khan Adil A. , Behera Rakesh , Ahuja Sana , Ahluwalia Charanjeet 
Published: August 2024

ABSTRACT
Primary transitional cell carcinoma of endometrium or an endometrial carcinoma with an extensive transitional cell differentiation is an extremely rare entity and always poses a diagnostic and therapeutic challenge to clinicians and pathologists. We present a 70-year-old lady who presented with postmenopausal bleeding. Grossly, a gray white tumor was identified in the fundus region of the uterus and was invading >50% into the myometrium. Histopathological sections examined from the tumor showed a highly cellular tumor arranged in nests and tightly packed papillary structures with thin fibrovascular cores covered by multilayered polygonal cells. On immunohistochemistry, the tumor cells were positive for CK7, ER, vimentin, and focally positive for p16. The present case was reported to emphasize its clinical and histological features which will broaden the morphological spectrum of epithelial neoplasms of endometrium.
Can dysphagia aspiration related structures (DARS) be spared in patients with oropharyngeal cancers? Dosimetric evaluation in a prospective study of DARS optimized intensity modulated radiation therapy
Authors: Calcuttawala Adnan , Shinghal Abhishek , Budrukkar Ashwini N. , Swain Monali , Murthy Vedang , Laskar Sarbani G. , Gupta Tejpal , Upereti Rituraj , Kale Shrikant , Agarwal Jai Prakash 
Published: August 2024

ABSTRACT

Purpose:
To evaluate the feasibility of sparing the dysphagia-aspiration-related structures (DARS) in various head and neck cancer sites treated with definitive DARS-optimized intensity modulated radiation therapy (IMRT) and concurrent chemotherapy.

Materials and Methods:
Target volumes, organs at risk, and in addition, individual DARS were delineated, including the superior, middle, and inferior pharyngeal constrictor muscles, supraglottic and glottic larynx, the base of the tongue, esophageal inlet muscles and cervical esophagus in 35 patients with head and neck squamous cell carcinoma. Volume-based dose constraints were applied to the DARS outside the planning target volume (PTV). An IMRT plan was then generated to limit doses to DARS without compromising PTV dose coverage.

Results:
Twelve (34.3%) patients had an oropharyngeal primary (OPX), 18 (51.4%) had a laryngeal, and 5 (14.3%) patients had hypopharyngeal primary. The mean dose to the DARS was 47.93 Gy for the entire group, while it was 54.6 Gy in oropharyngeal primaries and 44.4 Gy in laryngopharyngeal primaries. DARS mean dose of ≤45 Gy could be achieved in a significantly lesser number of patients with oropharyngeal primaries (P < 0.02). Similarly, DARS mean dose was 42.25 Gy in patients with N0 disease, 49.6 Gy with ipsilateral involved nodes, and 55 Gy with bilateral disease. Sparing of DARS was feasible when the volume of PTV was ≤150 cc (P < 0.025).

Conclusion:
Sparing of DARS structures appears to be challenging in patients with oropharyngeal cancers without compromising the dose to the PTVs while it is feasible in laryngopharyngeal cancers. DARS sparing is feasible when the PTV volume is < 150 cc and in patients with negative or unilateral nodal disease.
Comparison of magnetic seed and RFID methods in the localization of non-palpable breast lesions
Authors: Sanli Ahmet Necati , Tekcan Sanli Deniz E. , Golshan Mehra , Sezgin Efe , Celik Varol , Aydogan Fatih 
Published: August 2024

ABSTRACT

Background:
Many methods have been developed for localizing non-palpable breast lesions. This study investigated the success rate and surgical results of the magnetic seed (Magseed) and radiofrequency identification (RFID) method, which are relatively new compared to standard wire-guided localizations.

Materials and Methods:
20 simulation (10 Magseed, 10 RFID) models were created using turkey breasts and raisins. Raisins containing magnetic seed and RFID tags were placed on the turkey breast. Sentimag® probe was used for the Magseed group, and Faxitron LOCalizer™ System device was used in the RFID group. Both methods were evaluated in terms of accuracy in detecting breast lesion localization, operation times, excised tissue weights, total resection volume, surgical margin negativity, and re-excision rates.

Results:
Lesion localization success in both techniques was 100%. While procedure times were statistically significantly shorter in the Magseed group, incision lengths were shorter in the RFID group (P = 0.013, P = 0.007, respectively). No statistically significant difference was found between the groups for the weight of the removed parts, total resection volume, and surgical margin distance (P > 0.05).

Conclusion:
In this feasibility study, it was concluded that neither the RFID nor Magseed methods had a significant advantage over each other, in terms of localization detection and surgical margin negativity, and both methods could be used successfully for localization.
Adenomatoid tumor uterus coexisting with high grade serous carcinoma ovary: An incidental finding with literature review
Authors: Kumar Rabish , Mandal Shramana , Mallya Varuna , Mala Y. M. 
Published: August 2024

ABSTRACT
Adenomatoid tumor is a benign neoplasm of mesothelial origin encountered most often in the male and female genital tracts. These are generally small, benign lesions and are mostly incidental findings. Here we present a case of adenomatoid tumor uterus incidentally detected in a 39-year-old female who was operated for cystic lesion in the ovary.
An unusual presentation of oral metastasis of mucinous colorectal adenocarcinoma: A rare clinical entity and diagnostic challenge
Authors: Aggarwal Dipanshu , Shetty Devi C. , Gupta Amit , Saluja Meenakshi 
Published: August 2024

ABSTRACT
Mucinous colorectal adenocarcinoma represents a distinctive variant of colorectal carcinoma (CRC), which is typified by copious amounts of extracellular mucin. This subtype of CRC is distinguished by the presence of mucin, which constitutes at least 50% of the tumor volume, thus serving as a defining histologic feature of this malignancy. Colorectal carcinoma patients may develop lymphocytic and hematogenous metastases. While surgery is the only curative treatment option available, the use of chemotherapy, radiation therapy, or a combination of both can help improve the prognosis. However, the risk of recurrence remains substantial, in terms of both locoregional and distant spread. This article reports a gingival metastatic carcinoma of colorectal mucinous adenocarcinoma in a 24-year-old woman. Microscopically, architectural and cellular features resulted in ruling out differentials. Oral metastases are an infrequent phenomenon that can arise within either the soft tissues or the osseous structures of the oral cavity. This metastasis can exhibit clinical and radiographic features that are reminiscent of clear cell lesions localized in the head and neck region.
Total skin radiation therapy with low-dose helical tomotherapy for a patient with mycosis fungoides
Authors: Katano Atsuto , Yamashita Hideomi 
Published: August 2024

ABSTRACT
Total body skin irradiation with electron beams has been used for patients with mycosis fungoides (MF). Recently, helical tomotherapy was considered available for total body irradiation, although severe myelosuppression was frequently observed as an adverse event. We report the first case of low-dose helical tomotherapy in a patient with MF. An 87-year-old Asian male with an 18-year medical history of MF was referred to our department due to a rapidly growing skin lesion during systemic therapy. He decided to undergo low-dose total skin radiotherapy with helical tomotherapy. The total skin was treated by dividing into three parts (trunk, head, and lower extremities). Each part was treated with helical radiotherapy consisting of 10 Gy in 5 fractions, with the administration of 5 fractions per week. Once the skin lesion clearly disappeared after total skin radiotherapy, recurrence was detected in the lower abdominal wall in the radiation-treated field. Insufficient doses of radiation therapy cause early relapse. There is still no optimized dose for total skin irradiation in helical tomotherapy. Further radiation therapy dose trials are required to optimize the treatment schedule.
Impact of two intervention packages on the health and fitness of ante - and post-natal women attending in a teaching hospital
Authors: Sarkar Pradip Kumar , Singh Paramvir , Dhillon Mandeep Singh , Singh Amarjeet , Bhattacharya Sudip 
Published: August 2024

Introduction:
Pregnancy brings about many changes in mothers’ body which continue even after the baby is born. After a vaginal delivery, taking good care of the mother is an essential part of postpartum care and to maintain overall fitness.

Objective:
The purpose of this research was to evaluate the effect of a physiotherapeutic intervention to improve the maternity fitness of Indian women.

Methodology:
It was a three-group RCT (randomized controlled trial). The target population consisted of women in ante and postnatal stage, 50 participants (58 were included in the end) in each group, randomly selected from Obstetrics and Gynecology OPD of a tertiary care hospital in North India. The study was carried out in the department of PRM (Physiotherapy). A total of 174 participants was included in the study and was divided into three groups, two intervention groups, and one control group. The target population consisted of women in ante and postnatal stage, randomly selected from ANC (Antenatal clinic) and PNC (Post-natal clinic). The study was conducted over a period of 4 years (2014–2018). They were advised to do exercise, postural correction, regular walking, and electrotherapy modalities and six follow-ups throughout their pregnancy. Outcome measures like (Visual Analogue Scale = VAS): Low and upper back pain relief (n = 158), Leg cramps (n = 41), Coccyx pain (n = 36), Sacro-iliac joint pain (n = 26) was considered.

Results:
The impact of the intervention package on both ante-natal and post-natal women with fitness-related health problems showed significant improvement.

Conclusion:
Pain, leg cramp and heaviness in the lower limb, coccyx pain, etc., during pregnancy are common complaints that start early in pregnancy and may persist throughout life if treatment does not start early in the pregnancy.
Evaluation of Cardiovascular Risk Profile and Risk Scores of Antiretroviral Therapy-naïve HIV Patients in Eastern India
Authors: Chaubey Manaswi , Chakravarty Jaya , Gupta Rishabh , Jethwani Parth , Puri Rahul , Sundar Shyam 
Published: August 2024

Introduction:
People living with human immunodeficiency virus (PLHIV) are known to have an increased prevalence of traditional cardiovascular risk factors and are at a higher risk of cardiovascular disease (CVD). This study was done to assess the CVD risk factors in treatment naïve PLHIV in a center of the national program.

Methods:
In this cross-sectional explorative study, traditional CVD risk factors were assessed, and 10-year Framingham and atherosclerotic cardiovascular disease (ASCVD) risk score were calculated in treatment naïve PLHIV attending the antiretroviral therapy (ART) center, IMS, BHU.

Results:
The study included 337 ART naïve patients. The prevalence of CVD risk factors in treatment naïve PLHIV - were low high-density lipoprotein cholesterol levels (81.4%), high triglyceride levels (32.7%), smoking (32.3%), obesity (13.6%), hypertension (5%), diabetes (2.7%), and high low-density lipoprotein cholesterol levels (2.1%). Moderate-to-high 10-year Framingham Risk Score and American Heart Association/American College of Cardiology 10-year ASCVD risk score were 10.8% and 8.9%, respectively. In Framingham Risk Score, age ≥40 years (odds ratio [OR] - 131) (95% confidence interval [CI] - 6.5–1043) alcohol intake (OR - 5.14 [95% CI - 1.82–14.46] and presence of tuberculosis (OR - 4.78) (95% CI - 1.48-15.40), while in ASCVD risk score history of alcohol intake (OR - 26.20 [95% CI - 3.1-216.8] were at higher risk of CVD in multivariate variate analysis.

Conclusion:
CVD risk factors were common among ART naïve patient. Thus, screening, education, and treatment of CVD risk factors should be done in these patients at initiation of care.
Surgical Evaluation of Autologous Platelet-rich Fibrin Membrane as a Coverage Layer in Repair of Urethrocutaneous Fistula after Hypospadias Surgeries: A Randomized Controlled Trial
Authors: Wishahy Ahmed Mohamed Kadry , Abdullateef Khaled Salah Ahmed , Kaddah Sherif Nabhan , Mohamed Alaa Ali , Mohamed Mahmoud Tarek 
Published: August 2024

ABSTRACT

Purpose:
It has recently been reported that the use of platelet-rich fibrin (PRF) as an extralayer over the urethroplasty has been related to a considerable reduction in fistula rates. Due to the lack of evidence supporting the usage of PRF in urethrocutaneous fistula (UCF) repair, we conducted this study to evaluate the efficacy of PRF in patients with UCF.

Materials and Methods:
We conducted a randomized controlled study on patients with distal fistula after hypospadias repair. Patients were randomized into two groups, one with local dartos coverage and the other with PRF coverage layer.

Results:
In the present study, we included 37 patients; 20 patients underwent local dartos coverage, and 17 patients underwent PRF. The mean age was 22.45 ± 4545 ± 4515 ± ±15.35 (range 11–56) months for the study group and 20.6 ± 66 ± 614 ± ±14.5 (range 6–45) months for the control group. The incidence of recurrent UCF was 11.8% in the treatment group (two patients), whereas the incidence was 30% (six patients) in the control group (P = 0.246).

Conclusion:
UCF surgery may benefit from the use of PRF as a supportive tissue that promotes wound healing, angiogenesis, and tissue restoration. We believe that the use of PRF as a new approach for UCF repair should be investigated further through clinical studies.
Microbial Colonization Pattern of Indwelling Double J Stents in Children
Authors: Nishanth Sandeep , Babu Ramesh , Arunaa Sathyamurthy , Prasad D. Arun , Shanthi M. , Sekar Uma 
Published: August 2024

ABSTRACT

Background:
Indwelling double-J-stent (DJ stent) kept post-urological procedures may cause urinary tract infections (UTIs) due to polymicrobial biofilm formation and colonisation.

Aims:
To determine the incidence and microbiological characteristics of DJ stent related UTIs in a paediatric population.

Methods and Material:
Patients under the age of 18 admitted for DJ stent removal following pediatric urological procedures were enrolled into the study. Prior to surgical removal of the DJ stent, a urine sample was collected and the stent was cystoscopically removed under anesthesia. The ends of the stent were inoculated into culture media and incubated up to 48 hours. When growth was observed, an antibiogram was obtained using a panel of anti-microbial agents.

Results:
The study group consisted of 27 patients (M:F = 23:4) with a mean age of 4.3 years (1 month – 13 years). The commonest indication for stent placement was Pyeloplasty, 19 (70%). Stent colonisation was found in 8 out of 27 patients (29.6%; CI 12-51%) and E.Coli (33%) was the commonest organism. Polymicrobial growth was noted in 4 patients. Organisms were sensitive to Cephaerazone/ Sulbactam and Amikacin, and resistant to other Cephalosporins. All 8 culture positive patients were asymptomatic and a repeat urine culture revealed no growth. Colonisation did not lead to active UTI and post stent removal the urine became sterile.

Conclusions:
Microbial colonisation was noted in 30% of patients with indwelling DJ stents. Prior knowledge of culture & sensitivity pattern helps to cover the patients with appropriate antibiotic on the day of stent removal.
Survival Rate of Self-Adhesive Resin Cement on Various Crown Materials: A Scoping Review
Authors: Larasati Annisa Fildzah , Takarini Veni , Novianti Vita Mulya Passa 
Published: August 2024

Abstract

Aim:
The use of crowns made of all-ceramic, metal-ceramic, or porcelain fused to metal (PFM) with a self-adhesive resin cement as an indirect restorative process is a method of indirect restorative. The cement is anticipated to improve survival rates due to its many benefits. Thus, this research aimed to ascertain how long self-adhesive resin cement will last when applied to different types of crown materials.

Materials and Methods:
The study used a scoping review methodology that followed a Population, Concept, and Context framework. The articles included were published from January 1, 2013, to May 24, 2023, full-text, full-access, written in English, original article study design (clinical studies, observational studies, follow-up case reports, and comparative studies), and in vivo method. Boolean operators were applied to search across the databases Science Direct, PubMed, and EBSCOhost with the corresponding keywords “((survival rate) OR (success rate) AND (adhesive resin cement) AND (crown)).” Since Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) was implemented as the study design, it did not include randomization or statistical analysis. However, we added bias-risk information.

Results:
There were 104 studies in total. After the duplication checking and abstract screening processes, 23 articles were provided. A full-text assessment was done, and seven articles were extracted. Additionally, information about the author, publication year, study design, research methodology, self-adhesive resin cement brand, crown material, research duration, and outcomes was gathered.

Conclusions:
The results concluded that the self-adhesive resin cement survival rate on various crown materials, both all-ceramic and PFM, within 6 years is excellent. Due to the minimal number of articles that met the inclusion criteria, additional research is required.
Postoperative Pain of Endodontic Re-treatment in Single and Multiple Visits: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Swapna Sannapureddy , Niharika Mungara , Chinni Suneelkumar , Kiranmayi Govula , Pavankumar Yendluri , Anumula Lavanya 
Published: August 2024

Abstract

Aim:
This systematic review aimed to evaluate the influence of single-visit and multi-visit non-surgical endodontic re-treatments on the incidence, intensity, and duration of postoperative pain and adverse effects.

Materials and Methods:
A search of the literature was conducted after registration of the study protocols in PROSPERO to find randomized clinical studies assessing postoperative pain in non-surgical endodontic re-treatment conducted during one or more visits in PubMed, Cochrane library, and Scopus databases and EBSCO using a definitive search strategy based on inclusion and exclusion criteria. Using the Cochrane risk of bias method, two independent reviewers determined the studies that were eligible for inclusion, extracted data, and evaluated the quality. Meta-analysis was carried out at wherever appropriate.

Results:
A total of 827 citations were found by the database search and 16 citations from other sources. Eleven full-text articles were obtained after duplicates were eliminated. Three clinical trials were deemed eligible for inclusion; on qualitative evaluation, two studies showed an unclear risk and one was graded as having a significant high risk of bias. The sample size was significant in only one study, and the other two studies had a smaller sample size. Meta-analysis was performed at 24 h, 48 h, and 7 days. The random-effects model at 24 and 48 h and fixed-effects model after 7 days indicated that there is no significant difference in pain intensity between single-visit and multi-visit re-treatments.

Conclusion:
The significance of the number of visits on the subsequent pain following the re-treatment procedure was underlined by this current systematic review and meta-analysis. The single visit re-treatment caused less postoperative pain and can be considered based on the clinical scenario.
Bibliometric Analysis of 100 Most Cited Articles in Middle East and North Africa (MENA) Region on Implant Prosthodontics
Authors: Chitumalla Raj Kiran , Jamjoom Faris Z. , Haq Ikram Ul , Gopinathan Pillai Arun , Khan Sulthan Raja , Munaga Swapna 
Published: August 2024

Abstract

Aim:
This study aims to conduct a comprehensive analysis and scientometric evaluation of the top 100 most cited publications in the field of implant prosthodontics, authored by individuals affiliated with nations of the Middle East and North Africa (MENA) region.

Materials and Methods:
In October 2023, the 100 most cited articles were gathered from the Web of Science database using the bibliometric research technique. The analysis was conducted on bibliometric indicators, including the distribution of articles over time, authorship, design of study, field of study, nature of research, contribution from various countries in MENA, international research collaboration, and most frequently used keywords by authors. Chi-square and one-way analysis of variance were used for statistical analysis. VOSviewer software was used to analyze the bibliometric network for co-occurrence among countries, coauthors, and common keywords.

Results:
The results revealed that the top 100 most cited articles from MENA countries on the topic of implant prosthodontics, published between 1995 and 2020, had received an average of 73.31 citations each. About one-third of the papers were published in the top 4 journals. The journal with the most published articles was Clinical Oral Implant Research, followed by the International Journal of Oral & Maxillofacial Implants, the International Journal of Prosthodontics, and the Journal of Oral and Maxillofacial Surgery. Saudi Arabia had the distinction of producing the greatest number of highly cited papers. The co-occurrence network analysis using VOSviewer software identified 10–15 related clusters. Research studies with multiple authors received significantly more citations (P < 0.05). Significant relationships were observed between the number of citations and journal type (open access vs. non-open access; P < 0.05), and also articles published in dental journals received the most citations and were statistically significant (P = 0.001).

Conclusion:
Over the last decade, there has been a significant surge in research related to implant prosthodontics. Among the countries in the MENA region, Saudi Arabia has distinguished itself by leading in terms of overall research output. This resource would benefit academicians, clinicians, and researchers in prosthodontics, oral surgery, and periodontic specialties of dentistry.