bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of Efficacy of Drug Therapy in Preventing Takotsubo Cardiomyopathy Recurrence: A Meta‐analysis
Authors: Santoro Francesco , Ieva Riccardo , Musaico Francesco , Ferraretti Armando , Triggiani Giuseppe , Tarantino Nicola , Biase Matteo Di , Brunetti Natale Daniele 
Published: April 2014

AbstractBackgroundEfficacy of chronic drug therapy in prevention of stress‐induced cardiomyopathy recurrences is not well established. We therefore aimed to evaluate in this meta‐analysis whether pharmacological treatment can effectively prevent takotsubo cardiomyopathy (TTC) recurrences, according to available studies.HypothesisThere is no evidence for preventing TTC recurrence by drug therapy.MethodsAfter a PubMed search, we conducted a meta‐analysis of available studies (clinical nonrandomized registries) on efficacy of drug therapy in preventing recurrence of TTC.ResultsA total of 23 (4.5%) TTC recurrences occurred in the 511 patients included in the analysis. Seven studies on the effects of β‐blockers on prevention of TTC recurrence were evaluated; the odds ratio (OR) was 0.44 and the 95% confidence interval (CI) was 0.15‐1.31. In 5 studies on the effects of angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, the OR was 0.42 and the 95% CI was 0.08‐2.36; in 3 studies on statins, the OR was 0.74 and the 95% CI was 0.07‐7.3; and in 4 studies on aspirin, the OR was 0.33 with a 95% CI of 0.05‐2.17 (P value not significant in all cases).ConclusionsA meta‐analysis of the efficacy of different medications through the clinical TTC registries available showed no clinical evidence for a standard drug treatment in the chronic management of TTC. β‐Blockers, angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, statins, and aspirin do not seem to significantly reduce recurrences of TTC. Randomized, adequately powered studies are needed to further assess this issue.
Assessment of mutational profile of Japanese lung adenocarcinoma patients by multitarget assays: A prospective, single‐institute study
Authors: Serizawa Masakuni , Koh Yasuhiro , Kenmotsu Hirotsugu , Isaka Mitsuhiro , Murakami Haruyasu , Akamatsu Hiroaki , Mori Keita , Abe Masato , Hayashi Isamu , Taira Tetsuhiko , Maniwa Tomohiro , Takahashi Toshiaki , Endo Masahiro , Nakajima Takashi , Ohde Yasuhisa , Yamamoto Nobuyuki 
Published: April 2014

BACKGROUNDIntegration of mutational profiling to identify driver genetic alterations in a clinical setting is necessary to facilitate personalized lung cancer medicine. A tumor genotyping panel was developed and the Shizuoka Lung Cancer Mutation Study was initiated as a prospective tumor genotyping study. This study reports the frequency of driver genetic alterations in Japanese lung adenocarcinoma patients, and clinicopathologic correlations with each genotype.METHODSBetween July 2011 and January 2013, 411 lung adenocarcinoma patients admitted to the Shizuoka Cancer Center were included in this study with their written informed consent. Surgically resected tissues, tumor biopsies, and/or body cavity fluids were collected and tested for 23 hotspot sites of driver mutations in 9 genes (EGFR, KRAS, BRAF, PIK3CA, NRAS, MEK1, AKT1, PTEN, and HER2), gene amplifications in 5 genes (EGFR, MET, PIK3CA, FGFR1, and FGFR2), and ALK, ROS1, and RET fusions.RESULTSGenetic alterations were detected in 54.3% (223 of 411) of all patients. The most common genetic alterations detected in this study were EGFR mutations (35.0%) followed by KRAS mutations (8.5%) and ALK fusions (5.0%). Concurrent genetic alterations were detected in 22 patients (5.4%), and EGFR mutations were observed in 16 patients as the most common partner for concurrent genetic alteration. Significantly more concurrent genetic alterations were observed in older patients.CONCLUSIONSThis is one of the largest reports of a prospective tumor genotyping study on Japanese patients with adenocarcinoma. These data suggest that mutational profiling data using a multimutational testing platform would be valuable for expanding the range of molecular‐targeted therapeutics in lung cancer. Cancer 2014;120:1471–1481. © 2014 American Cancer Society.
Laterally Projecting Cerebrospinal Fluid‐Contacting Cells in the Lamprey Spinal Cord Are of Two Distinct Types
Authors: Jalalvand Elham , Robertson Brita , Wallén Peter , Hill Russell H. , Grillner Sten 
Published: April 2014

ABSTRACTCerebrospinal fluid‐contacting (CSF‐c) cells are found in all vertebrates, but their function remains elusive. In the lamprey spinal cord, they surround the central canal and some have processes passing the gray matter to the lateral edge of the flattened spinal cord. Stimulation of CSF‐c cells at the central canal elicits GABAergic inhibitory postsynaptic potentials (IPSPs) in intraspinal stretch receptor neurons (edge cells). Here, we characterize laterally projecting CSF‐c cells according to their morphology, phenotype, and neuronal properties by using immunohistochemistry, retrograde tracing, calcium imaging, and whole‐cell recordings. We identify two types of CSF‐c cells. Type 1 cells have a bulb‐like ending that protrudes into the central canal and a lateral process that ramifies ventrolaterally and laterally with a dense plexus surrounding the mechanosensitive dendrites of the edge cells. Most type 1 cells fire spontaneous action potentials that are abolished by tetrodotoxin, and all display spontaneous excitatory postsynaptic potentials and IPSPs that remain in the presence of tetrodotoxin. GABA and somatostatin are colocalized in type 1 cells, and they express both GABA and glutamate receptors. Type 2 cells, on the other hand, have a flat ending protruding into the central canal and a laterally projecting process that ramifies only at the lateral edge. These cells show immunoreactivity to taurine, but they do not express GABA or somatostatin, nor do they have any active neuronal properties. Type 2 cells might be a form of glia. Type 1 CSF‐c cells are neurons and may play a modulatory role by influencing edge cells and thus the locomotor‐related sensory feedback. J. Comp. Neurol. 522:1753–1768, 2014. © 2014 Wiley Periodicals, Inc.
RF and microwave high‐Q floating active inductor design and implementation
Authors: Branchi P. , Pantoli L. , Stornelli V. , Leuzzi G. 
Published: April 2014

SummaryIn this paper, a high‐Q floating active inductor (FAI), suitable for RF and microwave applications, is presented. The proposed FAI is based on two cascaded pairs of highly linear capacitance gyrators, which provide a symmetric and reciprocal structure. The proposed FAI shows fully symmetrical two‐port characteristics, high quality factor and high linearity. As a feasibility demonstration, a prototype of the designed FAI has been fabricated, together with an LC series band‐pass filter. At the operating frequency, the real part of the impedance of the equivalent FAI is very low (Req = 0.0039 Ω), providing a very high quality factor. The filter has a central frequency of 430 MHz and a −3 dB bandwidth of about 9 MHz. Copyright © 2014 John Wiley & Sons, Ltd.
The MAP1B case: An old MAP that is new again
Authors: Villarroel‐Campos David , Gonzalez‐Billault Christian 
Published: April 2014

ABSTRACTThe functions of microtubule‐associated protein 1B (MAP1B) have historically been linked to the development of the nervous system, based on its very early expression in neurons and glial cells. Moreover, mice in which MAP1B is genetically inactivated have been used extensively to show its role in axonal elongation, neuronal migration, and axonal guidance. In the last few years, it has become apparent that MAP1B has other cellular and molecular functions that are not related to its microtubule‐stabilizing properties in the embryonic and adult brain. In this review, we present a systematic review of the canonical and novel functions of MAP1B and propose that, in addition to regulating the polymerization of microtubule and actin microfilaments, MAP1B also acts as a signaling protein involved in normal physiology and pathological conditions in the nervous system. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 953–971, 2014
Construction of Metal–Organic Frameworks Consisting of Dinuclear Metal Units Based on 5‐Hydroxyisophthalate and Flexible Dipyridyl Ligands
Authors: Li Xiaoju , Guan Tena , Guo Xiaofang , Li Xinxiong , Yu Zhenjiang 
Published: April 2014

AbstractFour CoII and CuII complexes, namely, [Co2(ip‐OH)2(dpe)]n [1; ip‐OH = 5‐hydroxyisophthalate, dpe = 1,2‐di(4‐pyridyl)ethane], [Co2(ip‐OH)2(dpy)2]n(dpy)n(H2O)2n [2; dpy = 1,2‐di(4‐pyridyl)ethylene], [Cu2(ip‐OH)2(dpe)]n (3), and [Cu2(ip‐OH)2(dpy)]n (4), were hydrothermally synthesized and characterized. Single‐crystal X‐ray diffraction studies reveal that 1–4 consist of different dinuclear metal units, ip‐OH possesses different coordination modes, and both dpe and dpy adopt anti conformations. In 1, the ip‐OH ligands link dinuclear CoII units into a charge‐neutral [Co2(ip‐OH)2]n layer, which is further connected by pillars of dpe to generate a twofold interpenetrating 3D network. However, dinuclear CoII units in 2 are bridged by ip‐OH to form a 1D [Co2(ip‐OH)2]n chain, which is further connected by dpy into a 2D network consisting of the prismatic building blocks [Co8(ip‐OH)8(dpy)8]. Similarly to 1, 3 and 4 are twofold interpenetrating α‐Po architectures, despite the different ip‐OH bridging modes and different coordination geometries of the metal ions. The dinuclear units in 1–4 are well separated by ip‐OH and dpe/dpy ligands. The magnetic data of 1–3 are fitted according to the dimeric modes, and the results of the best fit indicate the existence of antiferromagnetic exchange between the metal centers in the dinuclear metal units.
Comparison of Electrochemical Oxidation of Flavonols and Calculated Proton Affinity and Electron Transfer Enthalpy in Water
Authors: Kummer Sina , Ruth Wolfgang , Kühn Oliver , Kragl Udo 
Published: April 2014

AbstractFlavonols, a class of flavonoids, are present in flowers, fruits and vegetables. They are jointly responsible for antioxidant activity as free radical acceptors. The redox behaviour of myricetin, quercetin, isorhamnetin, fisetin, morin and kaempferol is investigated using cyclic and differential pulse voltammetry. Quantum chemical calculations of proton affinities and electron transfer enthalpies were performed to identify possible reactive sites and radical species to compare them with measured oxidation potentials of the flavonols. Regarding to their chemical structure, these flavonols showed an oxidation order: myricetin > quercetin > isorhamnetin > fisetin > morin > kaempferol.
A Novel Electrochemical Sensor for β2‐Agonists with High Sensitivity and Selectivity Based on Surface Molecularly Imprinted Sol‐gel Doped with Antimony‐Doped Tin Oxide
Authors: Lei Rulin , Guo Chunhui , Xiong Huayu , Dong Chao , Zhang Xiuhua , Wang Shengfu 
Published: April 2014

AbstractA novel strategy to improve the sensitivity of molecularly imprinted polymer (MIP) sensors was proposed for the determination of β2‐agonists. The imprinted sol‐gel film was prepared by mixing silica sol with a functional monomer of antimony‐doped tin oxide (ATO) and a template of β2‐agonists. ATO, which was embedded in the surface of the molecularly imprinted sol‐gel film, not only provides the excellent conductivity for biosensor but also increases the stability and the surface area of the MIP film. The imprinted sensor was characterised by field emission scanning electron microscope, fourier transform infrared spectroscopy and electrochemical methods. Under the optimal experimental conditions, the peak current was linear with the logarithm of the concentration of clenbuterol (CLB) in the range of 5.5 nM–6.3 µM, and a detection limit of 1.7 nM was obtained. Meanwhile, the electrochemical sensor showed excellent specific recognition of the template molecule among structurally similar coexisting substances. Furthermore, the proposed sensor was satisfactorily applied to determine β2‐agonists in human serum samples. The good results indicated that highly effective molecularly imprinted sol‐gel films doped with ATO can be employed for other analytes.
Longitudinal reliability of tract‐based spatial statistics in diffusion tensor imaging
Authors: Madhyastha Tara , Mérillat Susan , Hirsiger Sarah , Bezzola Ladina , Liem Franziskus , Grabowski Thomas , Jäncke Lutz 
Published: April 2014

AbstractRelatively little is known about reliability of longitudinal diffusion‐tensor imaging (DTI) measurements despite growing interest in using DTI to track change in white matter structure. The purpose of this study is to quantify within‐ and between session scan‐rescan reliability of DTI‐derived measures that are commonly used to describe the characteristics of neural white matter in the context of neural plasticity research. DTI data were acquired from 16 cognitively healthy older adults (mean age 68.4). We used the Tract‐Based Spatial Statistics (TBSS) approach implemented in FSL, evaluating how different DTI preprocessing choices affect reliability indices. Test‐Retest reliability, quantified as ICC averaged across the voxels of the TBSS skeleton, ranged from 0.524 to 0.798 depending on the specific DTI‐derived measure and the applied preprocessing steps. The two main preprocessing steps that we found to improve TBSS reliability were (a) the use of a common individual template and (b) smoothing DTI data using a 1‐voxel median filter. Overall our data indicate that small choices in the preprocessing pipeline have a significant effect on test‐retest reliability, therefore influencing the power to detect change within a longitudinal study. Furthermore, differences in the data processing pipeline limit the comparability of results across studies. Hum Brain Mapp 35:4544–4555, 2014. © 2014 Wiley Periodicals, Inc.
Movement‐related neuromagnetic fields in preschool age children
Authors: Cheyne Douglas , Jobst Cecilia , Tesan Graciela , Crain Stephen , Johnson Blake 
Published: April 2014

AbstractWe examined sensorimotor brain activity associated with voluntary movements in preschool children using a customized pediatric magnetoencephalographic system. A videogame‐like task was used to generate self‐initiated right or left index finger movements in 17 healthy right‐handed subjects (8 females, ages 3.2–4.8 years). We successfully identified spatiotemporal patterns of movement‐related brain activity in 15/17 children using beamformer source analysis and surrogate MRI spatial normalization. Readiness fields in the contralateral sensorimotor cortex began ∼0.5 s prior to movement onset (motor field, MF), followed by transient movement‐evoked fields (MEFs), similar to that observed during self‐paced movements in adults, but slightly delayed and with inverted source polarities. We also observed modulation of mu (8–12 Hz) and beta (15–30 Hz) oscillations in sensorimotor cortex with movement, but with different timing and a stronger frequency band coupling compared to that observed in adults. Adult‐like high‐frequency (70–80 Hz) gamma bursts were detected at movement onset. All children showed activation of the right superior temporal gyrus that was independent of the side of movement, a response that has not been reported in adults. These results provide new insights into the development of movement‐related brain function, for an age group in which no previous data exist. The results show that children under 5 years of age have markedly different patterns of movement‐related brain activity in comparison to older children and adults, and indicate that significant maturational changes occur in the sensorimotor system between the preschool years and later childhood. Hum Brain Mapp 35:4858–4875, 2014. © 2014 Wiley Periodicals, Inc.
Voxelwise lp‐ntPET for detecting localized, transient dopamine release of unknown timing: Sensitivity Analysis and Application to Cigarette Smoking in the PET Scanner
Authors: Kim Su Jin , Sullivan Jenna M. , Wang Shuo , Cosgrove Kelly P. , Morris Evan D. 
Published: April 2014

AbstractThe “linear parametric neurotransmitter PET” (lp‐ntPET) model estimates time variation in endogenous neurotransmitter levels from dynamic PET data. The pattern of dopamine (DA) change over time may be an important element of the brain's response to addictive substances such as cigarettes or alcohol. We have extended the lp‐ntPET model from the original region of interest (ROI) ‐ based implementation to be able to apply the model at the voxel level. The resulting endpoint is a dynamic image, or movie, of transient neurotransmitter changes. Simulations were performed to select threshold values to reduce the false positive rate when applied to real 11C‐raclopride PET data. We tested the new voxelwise method on simulated data, and finally, we applied it to 11C‐raclopride PET data of subjects smoking cigarettes in the PET scanner. In simulation, the temporal precision of neurotransmitter response was shown to be similar to that of ROI‐based lp‐ntPET (standard deviation ∼ 3 min). False positive rates for the voxelwise method were well controlled by combining a statistical threshold (the F‐test) with a new spatial (cluster‐size) thresholding operation. Sensitivity of detection for the new algorithm was greater than 80% for the case of short‐lived DA changes that occur in subregions of the striatum as might be the case with cigarette smoking. Finally, in 11C‐raclopride PET data, DA movies reveal for the first time that different temporal patterns of the DA response to smoking may exist in different subregions of the striatum. These spatiotemporal patterns of neurotransmitter change created by voxelwise lp‐ntPET may serve as novel biomarkers for addiction and/or treatment efficacy. Hum Brain Mapp 35:4876–4891, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
Selenophene Electronics
Authors: Hollinger Jon , Gao Dong , Seferos Dwight S. 
Published: April 2014

AbstractSubstituting individual heavier (or lighter) atoms would appear to be an extremely straightforward method of controlling the optoelectronic properties of π‐conjugated molecules that has minimal impact on solid‐state materials properties, yet things are never as they appear. Selenophenes are a distinct class of material separate from thiophenes. Their HOMOLUMO gap is often narrow, which is attractive for photonic applications. Intermolecular SeSe interactions increase ordering on a molecular scale and lead to distinct solid‐state organization, which often leads to excellent charge‐transport properties. The crystallization of selenophene is distinct from thiophenes, and thus, composites of selenophenes and other organic materials have distinct nano‐ and microscale morphologies. Some of the best organic optoelectronic devices use selenophene‐containing materials, yet early results were less encouraging. The most recent syntheses, structure determination, and electronic device properties of π‐conjugated selenophene‐based materials are reviewed. Significantly more work is justified and this review sets the stage for those studies.
Job stress is associated with migraine in current workers: The Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil)
Authors: Santos I.S. , Griep R.H. , Alves M.G.M. , Goulart A.C. , Lotufo P.A. , Barreto S.M. , Chor D. , Benseñor I.M. 
Published: April 2014

AbstractBackgroundMigraine is an important source of social burden and work‐related costs. Studies addressing the association of migraine with job stress are rare.ObjectivesThe aim of this paper was to study the association of job stress components and migraine using structured, validated questionnaires that were part of the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil).MethodsThe ELSA‐Brasil is a multicentre cohort of 15,105 civil servants (12,096 current workers) in Brazil. Job strain was assessed using the 17‐item Brazilian version of the Swedish Demand‐Control‐Support Questionnaire. Headache episodes in the preceding 12 months were assessed using a questionnaire based on the International Headache Society criteria. We analysed the association between job stress domains and migraine in men and women using adjusted logistic regression and interaction models.ResultsWe included 3113 individuals without headache and 3259 migraineurs. Low job control [odds ratio (OR) 1.30; 95% confidence interval (95% CI) 1.10–1.53], high job demands (OR 1.37; 95% CI 1.18–1.59) and low social support (OR 1.49; 95% CI 1.29–1.71) were associated with migraine. Job control was more strongly associated with migraine in women (p for interaction = 0.02). High‐strain (high demand and low control) jobs were associated with migraine in both men (OR 1.48; 95% CI 1.11–1.97) and women (OR 1.51; 95% CI 1.17–1.95).ConclusionsWe observed a strong association between high‐strain jobs and migraine. Job control was a stronger migraine‐related factor for women. Low social support was associated with migraine in both sexes.
Identifying subgroups of paediatric chronic pain patients: A cluster‐analytic approach
Authors: Wager J. , Zernikow B. , Darlington A. , Vocks S. , Hechler T. 
Published: April 2014

AbstractBackgroundPaediatric chronic pain patients are a heterogeneous group. Individuals respond differently to standardized treatment.ObjectivesThis study aimed to identify subgroups of adolescent chronic pain patients.MethodsSubgroups were identified by means of a cluster analysis (Sample A, nA = 266). The stability of clusters was tested in a cross‐validation with a second sample (Sample B, nB = 108). In a third sample (Sample C, nC = 83), differences in change scores of the outcome parameters were tested between cluster subgroups 12 months after a standardized treatment.ResultsFive distinct cluster subgroups with pain problems differing by pain intensity, school absence, pain‐related disability, passive pain coping and affective pain perception were identified. Two groups reported overall moderate pain problems and differed with regard to passive pain coping, which was low in Cluster 1 and moderate in Cluster 2. The patients in Cluster 3 reported severe pain problems, including high pain‐related disability and frequent school absences. The patients in Clusters 4 and 5 reported very severe pain problems, with those in Cluster 5 reporting very frequent school absences. Cross‐validation was performed to assess the accuracy of our subgrouping and indicated a stable cluster solution (κ = 0.64). The five subgroups displayed distinct patterns in treatment outcome after a standardized multidisciplinary treatment program. The mean change scores were significantly different between subgroups [F(4,78) = 5.88; p = 0.017].ConclusionsThe patient subgroups that were established proved stable across samples. Depending on the subgroup classification, patients differed in changes of core outcomes. These results offer initial hints for the need for subgroup‐specific treatment planning.