bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
Authors: Yang Ting , Liu Wentao , He Jiali , Gui Chenfan , Meng Lijiao , Xu Li , Jia Chengsen 
Published: June 2024

Abstract
Background
Non-invasive brain stimulation (NIBS) combined with cognitive training (CT) may have shown some prospects on improving cognitive function in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). However, data from clinical trials or meta-analysis involving NIBS combined with CT have shown controversial results. The aim of this systematic review and meta-analysis was to evaluate short-term and long-term effects of NIBS combined with CT on improving global cognition and other specific cognitive domains in patients with AD and MCI.

Methods
This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Five electronic databases including PubMed, Web of Science, EBSCO, Cochrane Library and Embase were searched up from inception to 20 November 2023. The PEDro scale and the Cochrane’s risk of bias assessment were used to evaluate risk of bias and methodological quality of included studies. All statistical analyses were conducted with Review Manager 5.3.

Results
We included 15 studies with 685 patients. The PEDro scale was used to assess methodological quality with a mean score of 7.9. The results of meta-analysis showed that NIBS combined with CT was effective on improving global cognition in AD and MCI (SMD = 0.52, 95% CI (0.18, 0.87), p = 0.003), especially for patients accepting repetitive transcranial magnetic stimulation (rTMS) combined with CT (SMD = 0.46, 95% CI (0.14, 0.78), p = 0.005). AD could achieve global cognition improvement from NIBS combined with CT group (SMD = 0.77, 95% CI (0.19, 1.35), p = 0.01). Transcranial direct current stimulation (tDCS) combined with CT could improve language function in AD and MCI (SMD = 0.29, 95% CI (0.03, 0.55), p = 0.03). At evaluation follow-up, rTMS combined with CT exhibited larger therapeutic responses to AD and MCI in global cognition (SMD = 0.55, 95% CI (0.09, 1.02), p = 0.02). AD could achieve global cognition (SMD = 0.40, 95% CI (0.03, 0.77), p = 0.03) and attention/working memory (SMD = 0.72, 95% CI (0.23, 1.20), p = 0.004) improvement after evaluation follow-up from NIBS combined with CT group.

Conclusions
Overall, NIBS combined with CT, particularly rTMS combined with CT, has both short-term and follow-up effects on improving global cognition, mainly in patients with AD. tDCS combined with CT has advantages on improving language function in AD and MCI. Future more studies need evaluate cognitive effects of NIBS combined with CT on other specific cognitive domain in patients with cognitive deterioration.
Chemotherapy-related cardiotoxicity and its symptoms in patients with breast cancer: a scoping review
Authors: Kim Hyunjoo , Hong Bomi , Kim Sanghee , Kang Seok-Min , Park Jeongok 
Published: June 2024

Abstract
Background
Chemotherapy-related cardiotoxicity is a significant concern because it is a major cause of morbidity. This study aimed to provide in-depth information on the symptoms of chemotherapy-related cardiotoxicity (CRCT) by exploring literature that concurrently reports the types and symptoms of CRCT in patients with breast cancer.

Methods
A scoping review was performed according to an a priori protocol using the Joanna Briggs Institute’s guidelines. The participants were patients with breast cancer. The concept was the literature of specifically reported symptoms directly matched with CRCT and the literature, in English, from 2010, and the context was open. The search strategy included four keywords: “breast cancer,” “chemotherapy,” “cardiotoxicity,” and “symptoms.” All types of research designs were included; however, studies involving patients with other cancer types, animal subjects, and symptoms not directly related to CRCT were excluded. Data were extracted and presented including tables and figures.

Results
A total of 29 articles were included in the study, consisting of 23 case reports, 4 retrospective studies, and 2 prospective studies. There were no restrictions on the participants’ sex; however, all of them were women, except for one case report. The most used chemotherapy regimens were trastuzumab, capecitabine, and doxorubicin or epirubicin. The primary CRCT identified were myocardial dysfunction and heart failure, followed by coronary artery disease, pulmonary hypertension, and other conditions. Major tests used to diagnose CRCT include echocardiography, electrocardiography, serum cardiac enzymes, coronary angiography, computed tomography, and magnetic resonance imaging. In all case reports, CRCT was diagnosed through an incidental checkup according to the patient’s symptom presentation; however, only 10 of these studies showed a baseline checkup before chemotherapy. The five most common CRCT symptoms were dyspnea, chest pain, peripheral edema, fatigue, and palpitations, which were assessed by patient-reported symptom presentation rather than using a symptom assessment tool. Dyspnea with trastuzumab treatment and chest pain with capecitabine treatment were particularly characteristic. The time for first symptom onset after chemotherapy ranged from 1 hour to 300 days, with anthracycline-based regimens requiring 3–55 days, trastuzumab requiring 60–300 days, and capecitabine requiring 1–7 days.

Conclusions
This scoping review allowed data mapping according to the study design and chemotherapy regimens. Cardiac assessments for CRCT diagnosis were performed according to the patient’s symptoms. There were approximately five types of typical CRCT symptoms, and the timing of symptom occurrence varied. Therefore, developing and applying a CRCT-specific and user-friendly symptom assessment tool are expected to help healthcare providers and patients manage CRCT symptoms effectively.
Laparoscopic liver resection for a patient of hepatocellular carcinoma with von Willebrand disease: a case report
Authors: Şal Oğuzhan , Sakamoto Katsunori , Tamura Kei , Honjo Masahiko , Nishi Yusuke , Funamizu Naotake , Ogawa Kohei , Takada Yasutsugu 
Published: June 2024

Abstract
Background
The safety of laparoscopic hepatectomy for inherited coagulation disorders is unclear; however, the safety of open hepatectomy has been reported in several studies. Herein, we report the first case of a laparoscopic hepatectomy for a patient with von Willebrand Disease (VWD).

Case presentation
A 76-year-old male with a history of chronic hepatitis C and VWD type 2B was advised surgical resection of a 4 cm hepatocellular carcinoma in segment 7 of the liver. The patient was diagnosed with VWD in his 40 s due to gastrointestinal bleeding caused by gastric erosion. The von Willebrand factor (VWF) ristocetin cofactor activity was 30%, and VWF large multimer deficiency and increased ristocetin-induced platelet agglutination were observed. The preoperative platelet count was reduced to 3.5 × 104/μL; however, preoperative imaging findings had no evidence of liver cirrhosis, such as any collateral formations and splenomegaly. The indocyanine green retention rate at 15 min was 10%, and his Child–Pugh score was 5 (classification A). Perioperatively, VWF/factor VIII was administered in accordance with our institutional protocol. A laparoscopic partial hepatectomy of the right posterior segment was performed. The most bleeding during surgery occurred during the mobilization of the right lobe of the liver due to inflammatory adhesion between the retroperitoneum and the tumor. Bleeding during parenchymal transection was controlable. The duration of hepatic inflow occlusion was 65 min. The surgical duration was 349 min, and the estimated blood loss was 2150 ml. Four units of red blood cells and fresh frozen plasma were transfused at the initiation of parenchymal transection, and 10 units of platelets were transfused at the end of the parenchymal transection. On postoperative day 1, the transection surface drainage fluid became hemorrhagic, and emergency contrast-enhanced computed tomography showed extravasation in the greater omentum. Percutaneous transcatheter arterial embolization of the omental branch of the right gastroepiploic artery was performed. No further postoperative interventions were required. The patient was discharged on postoperative day 14.

Conclusion
The indications for laparoscopic hepatectomy in patients with VWD should be carefully considered, and an open approach may still be the standard approach for patients with VWD.
Oleogels: Versatile Novel Semi-Solid System for Pharmaceuticals
Authors: Pawar Vaishnavi U. , Dessai Akanksha D. , Nayak Usha Y. 
Published: June 2024

AbstractOleogels is a novel semi-solid system, focusing on its composition, formulation, characterization, and diverse pharmaceutical applications. Due to their stability, smoothness, and controlled release qualities, oleogels are frequently utilized in food, cosmetics, and medicinal products. Oleogels are meticulously formulated by combining oleogelators like waxes, fatty acids, ethyl cellulose, and phytosterols with edible oils, leading to a nuanced understanding of their impact on rheological characteristics. They can be characterized by methods like visual inspection, texture analysis, rheological measurements, gelation tests, and microscopy. The applications of oleogels are explored in diverse fields such as nutraceuticals, cosmetics, food, lubricants, and pharmaceutics. Oleogels have applications in topical, transdermal, and ocular drug delivery, showcasing their potential for revolutionizing drug administration. This review aims to enhance the understanding of oleogels, contributing to the evolving landscape of pharmaceutical formulations. Oleogels emerge as a versatile and promising solution, offering substantial potential for innovation in drug delivery and formulation practices.
Graphical Abstract
Transgender Women With Suppressed Testosterone Display Lower Burden of Coronary Disease Than Matched Cisgender Men
Authors: Lake Jordan E , Feng Han , Hyatt Ana N , Miao Hongyu , Debroy Paula , Funderburg Nicholas , Ailstock Kate , Dobs Adrian , Haberlen Sabina , Magnani Jared W , Margolick Joseph B , McGowan Kate , Palella Frank J , Witt Mallory D , Bhasin Shalender , Budoff Matthew J , Post Wendy S , Brown Todd T 
Published: June 2024

Abstract

Context
Cardiovascular disease (CVD) in transgender women (TW) may be affected by gender-affirming hormone therapy (GAHT) and HIV, but few data compare TW on contemporary GAHT to well-matched controls.

Objective
We compared CVD burden and biomarker profiles between TW and matched cisgender men (CM).

Methods
Adult TW on GAHT (n = 29) were recruited for a cross-sectional study (2018-2020). CM (n = 48) from the former Multicenter AIDS Cohort Study were matched 2:1 to TW on HIV serostatus, age ±5 years, race/ethnicity, BMI category and antiretroviral therapy (ART) type. Cardiac parameters were measured by CT and coronary atherosclerosis by coronary CT angiography; sex hormone and biomarker concentrations were measured centrally from stored samples.

Results
Overall, median age was 53 years and BMI 29 kg/m2; 69% were non-white. All participants with HIV (71%) had viral suppression on ART. Only 31% of TW had testosterone suppression (&lt;50 ng/dL, TW-S). Traditional CVD risk factors were similar between groups, except that TW-S had higher BMI than TW with non-suppressed testosterone (TW-T). TW-S had no evidence of non-calcified coronary plaque or advanced coronary stenosis, whereas TW-T and CM had similar burden. TW had lower prevalence of any coronary plaque, calcified plaque and mixed plaque than CM, regardless of testosterone concentrations and HIV serostatus. Estradiol but not testosterone concentrations moderately and negatively correlated with the presence of coronary plaque and stenosis. Small sample size limited statistical power.

Conclusion
Older TW with suppressed total testosterone on GAHT had no CT evidence of non-calcified coronary plaque or advanced coronary stenosis. Longitudinal studies to understand relationships between GAHT and CVD risk in TW are needed.
A Speech Neuroprosthesis in the Frontal Lobe and Hippocampus: Decoding High-Frequency Activity into Phonemes
Authors: Tankus Ariel , Stern Einat , Klein Guy , Kaptzon Nufar , Nash Lilac , Marziano Tal , Shamia Omer , Gurevitch Guy , Bergman Lottem , Goldstein Lilach , Fahoum Firas , Strauss Ido 
Published: June 2024

BACKGROUND AND OBJECTIVES:
Loss of speech due to injury or disease is devastating. Here, we report a novel speech neuroprosthesis that artificially articulates building blocks of speech based on high-frequency activity in brain areas never harnessed for a neuroprosthesis before: anterior cingulate and orbitofrontal cortices, and hippocampus.

METHODS:
A 37-year-old male neurosurgical epilepsy patient with intact speech, implanted with depth electrodes for clinical reasons only, silently controlled the neuroprosthesis almost immediately and in a natural way to voluntarily produce 2 vowel sounds.

RESULTS:
During the first set of trials, the participant made the neuroprosthesis produce the different vowel sounds artificially with 85% accuracy. In the following trials, performance improved consistently, which may be attributed to neuroplasticity. We show that a neuroprosthesis trained on overt speech data may be controlled silently.

CONCLUSION:
This may open the way for a novel strategy of neuroprosthesis implantation at earlier disease stages (eg, amyotrophic lateral sclerosis), while speech is intact, for improved training that still allows silent control at later stages. The results demonstrate clinical feasibility of direct decoding of high-frequency activity that includes spiking activity in the aforementioned areas for silent production of phonemes that may serve as a part of a neuroprosthesis for replacing lost speech control pathways.
Spermatogonial stem cells in the 129 inbred strain exhibit unique requirements for self-renewal
Authors: Kanatsu-Shinohara Mito , Yamamoto Takuya , Morimoto Hiroko , Liu Tianjiao , Shinohara Takashi 
Published: June 2024

ABSTRACT
Spermatogonial stem cells (SSCs) undergo self-renewal division to sustain spermatogenesis. Although it is possible to derive SSC cultures in most mouse strains, SSCs from a 129 background never proliferate under the same culture conditions, suggesting they have distinct self-renewal requirements. Here, we established long-term culture conditions for SSCs from mice of the 129 background (129 mice). An analysis of 129 testes showed significant reduction of GDNF and CXCL12, whereas FGF2, INHBA and INHBB were higher than in testes of C57BL/6 mice. An analysis of undifferentiated spermatogonia in 129 mice showed higher expression of Chrna4, which encodes an acetylcholine (Ach) receptor component. By supplementing medium with INHBA and Ach, SSC cultures were derived from 129 mice. Following lentivirus transduction for marking donor cells, transplanted cells re-initiated spermatogenesis in infertile mouse testes and produced transgenic offspring. These results suggest that the requirements of SSC self-renewal in mice are diverse, which has important implications for understanding self-renewal mechanisms in various animal species.
Impact of Eccentric versus Concentric Cycling Exercise on Neuromuscular Fatigue and Muscle Damage in Breast Cancer Patients
Authors: HUCTEAU ELYSE , MALLARD JORIS , BARBI CHIARA , VENTURELLI MASSIMO , SCHOTT ROLAND , TRENSZ PHILIPPE , PFLUMIO CAROLE , KALISH-WEINDLING MICHAL , PIVOT XAVIER , FAVRET FABRICE , DUCROCQ GUILLAUME P. , DUFOUR STÉPHANE P. , PAGANO ALLAN F. , HUREAU THOMAS J. 
Published: June 2024

ABSTRACT

Introduction
This study investigated the magnitude and etiology of neuromuscular fatigue and muscle damage induced by eccentric cycling compared with conventional concentric cycling in patients with breast cancer.

Methods
After a gradual familiarization protocol for eccentric cycling, nine patients with early-stage breast cancer performed three cycling sessions in eccentric or concentric mode. The eccentric cycling session (ECC) was compared with concentric cycling sessions matched for power output (CONpower; 80% of concentric peak power output, 95 ± 23 W) or oxygen uptake (

; 10 ± 2 mL·min·kg−1). Preexercise to postexercise changes (30-s through 10-min recovery) in knee extensor maximal voluntary contraction force (MVC), voluntary activation, and quadriceps potentiated twitch force (Q
tw) were quantified to determine global, central, and peripheral fatigue, respectively. Creatine kinase and lactate dehydrogenase activities were measured in the plasma before and 24 h after exercise as markers of muscle damage.

Results
Compared with CONpower (−11% ± 9%) and

(−5% ± 5%), the ECC session resulted in a greater decrease in MVC (−25% ± 12%) postexercise (P < 0.001). Voluntary activation decreased only in ECC (−9% ± 6% postexercise, P < 0.001). The decrease in Q
tw was similar postexercise between ECC and CONpower (−39% ± 21% and −40% ± 16%, P > 0.99) but lower in

(P < 0.001). The CONpower session resulted in twofold greater

compared with the ECC and

sessions (P < 0.001). No change in creatine kinase or lactate dehydrogenase activity was reported from preexercise to 24 h postexercise.

Conclusions
The ECC session induced greater neuromuscular fatigue compared with the concentric cycling sessions without generating severe muscle damage. ECC is a promising exercise modality for counteracting neuromuscular maladaptation in patients with breast cancer.
The Influence of Aging on the Unfolded Protein Response in Human Skeletal Muscle at Rest and after Acute Exercise
Authors: MICHIE KELLY L. , KUNZ HAWLEY E. , DASARI SURENDRA , LANZA IAN R. 
Published: June 2024

ABSTRACT

Background
The unfolded protein response (UPR) is a proteostatic process that is activated in response to endoplasmic reticulum stress. It is currently unclear how aging influences the chronic and adaptive UPR in human skeletal muscle. Here we determined the effect of aging on UPR activation at rest, in response to exercise, and the associations with muscle function.

Methods
Thirty young (20–35 yr) and 50 older (65–85 yr) individuals were enrolled. Vastus lateralis biopsies were performed at rest and 3 and 48 h after a single bout of resistance exercise. The abundance of UPR-related transcripts and proteins was measured by RNA sequencing and Western blotting, respectively. Fractional synthetic rates of muscle protein were determined by mass spectrometry after intravenous infusion of 13C6 phenylalanine.

Results
Older adults demonstrated elevated transcriptional and proteomic markers of UPR activation in resting muscle. Resting UPR gene expression was negatively associated with muscle strength and power in older adults. The UPR is similarly activated by acute resistance exercise in young and older adults and positively associated with muscle function but not the anabolic response to exercise.

Conclusions
Skeletal muscle from older adults exhibits chronically activated UPR, which accompanies functional decline. The adaptive UPR is a proteostatic mechanism that is upregulated in response to exercise in young and older adults and positively associated with muscle function.
The New York Scale of Anhedonia: Development and Validation of a New Measure
Authors: Barahmand Usha , Tewari Amisha , Iskander Simona , Castellanos Kayla , Yuabov Betty , Hermann Ezra 
Published: June 2024

Aim of the studyThe aim of this research was to develop and validate an instrument to screen for the presence of and change in the experience of anhedonia.Subject or material and methodsAn initial set of 23 items assessing intensity and change in lack of pleasure and loss of interest in various hedonic domains was created to form the New York Anhedonia Scale (NYSA). Study 1 explored the reliability, factor structure and item quality of the NYSA, which assessed the 23 items in two parts: Part A focused on identifying the presence and intensity of anhedonia, while Part B assessed change in anhedonia. A sample of 265 adults responded to the instrument via social media platforms.ResultsExploratory factor analysis of the 23-item NYSA revealed that 15 items clustered into two factors: sensory and physical anhedonia and social anhedonia. Study 2 evaluated the psychometric properties of the final version of the NYSA using a sample of 238 adults. The concurrent and convergent validity of the final version of the NYSA was examined with the Snaith-Hamilton Pleasure Scale (SHAPS) and the Social Interaction Anxiety Scale (SIAS). Good concurrent validity was found with the SHAPS and convergent validity with the SIAS. Reliability of the NYSA subscales was high across both studies.DiscussionThe NYSA is a tool different from other measures of anhedonia as it is not only quick to administer but also provides information regarding anhedonia intensity and change.ConclusionsThe NYSA is a useful and promising instrument for screening and assessing anhedonia in the general population and in clinical settings.
Australia and China: Friends or Foes? Implications for Security in the Indo-Pacific Region
Authors: Krukowska Monika Magdalena 
Published: June 2024

ObjectivesThe research aims to delineate and explain the state of bilateral relations between Australia and China in the context of the stability of the Indo-Pacific region.Material and methodsThe main tools used to achieve the objectives mentioned above include a literature analysis, statements, diplomatic and quantitative data from governmental sites, and logical reasoning.ResultsReliable and balanced bilateral relations between the People’s Republic of China, the largest regional power, and Australia, the most influential Western outpost in the Indo-Pacific, are sine qua non condition of stability in the region. However, within the last decade, there was far too much uncertainty and malevolence between the two parties to pass unnoticed: trade and investment restrictions on Chinese companies, not to mention political tensions due to unprecedented Chinese interference in Australia’s domestic affairs. The article analyzes bilateral Sino-Australian relations, including political, economic, and social dimensions, in the context of regional security issues.ConclusionsRelations between China and Australia are underpinned by their strong economic interdependence and Australia’s security alliance with the U.S. While concerns over trade tensions may soon be over, Australia needs to accommodate the reality of China’s more active presence in the Indo-Pacific region.