bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective atomic sieving across metal/oxide interface for super-oxidation resistance
Authors: Li Shuang , Yang Li , Christudasjustus Jijo , Overman Nicole R. , Wirth Brian D. , Sushko Maria L. , Simonnin Pauline , Schreiber Daniel K. , Gao Fei , Wang Chongmin 
Published: July 2024

AbstractSurface passivation, a desirable natural consequence during initial oxidation of alloys, is the foundation for functioning of corrosion and oxidation resistant alloys ranging from industrial stainless steel to kitchen utensils. This initial oxidation has been long perceived to vary with crystal facet, however, the underlying mechanism remains elusive. Here, using in situ environmental transmission electron microscopy, we gain atomic details on crystal facet dependent initial oxidation behavior in a model Ni-5Cr alloy. We find the (001) surface shows higher initial oxidation resistance as compared to the (111) surface. We reveal the crystal facet dependent oxidation is related to an interfacial atomic sieving effect, wherein the oxide/metal interface selectively promotes diffusion of certain atomic species. Density functional theory calculations rationalize the oxygen diffusion across Ni(111)/NiO(111) interface, as contrasted with Ni(001)/NiO(111), is enhanced. We unveil that crystal facet with initial fast oxidation rate could conversely switch to a slow steady state oxidation.
The Bifidobacterium-dominated fecal microbiome in dairy calves shapes the characteristic growth phenotype of host
Authors: Zhuang Yimin , Liu Shuai , Gao Duo , Xu Yiming , Jiang Wen , Chen Tianyu , Xiao Jianxin , Wang Jingjun , Hou Guobin , Li Sumin , Zhao Xinjie , Huang Yanting , Li Shangru , Zhang Siyuan , Li Mengmeng , Wang Wei , Li Shengli , Cao Zhijun 
Published: July 2024

AbstractThe dominant bacteria in the hindgut of calves play an important role in their growth and health, which could even lead to lifelong consequences. However, the identification of core probiotics in the hindgut and its mechanism regulating host growth remain unclear. Here, a total of 1045 fecal samples were analyzed by 16S rRNA gene sequencing from the 408 Holstein dairy calves at the age of 0, 14, 28, 42, 56, and 70 days to characterize the dynamic changes of core taxa. Moreover, the mechanisms of nutrient metabolism of calf growth regulated by core bacteria were investigated using multi-omics analyses. Finally, fecal microbiota transplantation (FMT) in mice were conducted to illustrate the potential beneficial effects of core bacteria. Four calf enterotypes were identified and enterotypes dominated byBifidobacteriumandOscillospiraceae_UCG-005were representative. The frequency of enterotype conversion shifted from variable to stable. The close relationship observed between phenotype and enterotype, revealing a potential pro-growth effect ofBifidobacterium, might be implemented by promoting the use of carbohydrate, activating the synthesis of volatile fatty acids, amino acids and vitamin B6, and inhibiting methane production in the hindgut. The FMT results indicated the beneficial effect ofBifidobacteriumon host growth and hindgut development. These results support the notion that theBifidobacterium-dominated fecal microbiome would be an important driving force for promoting the host growth in the early life. Our findings provide new insights into the potential probiotic mining and application strategies to promote the growth of young animals or improve their growth retardation.
Cr doping-induced ferromagnetism in SnTe thin films
Authors: Liu Shanshan , Zhang Enze , Li Zihan , Zhang Xiaoqian , Liu Wenqing , Narayan Awadhesh , Chen Zhi-Gang , Zou Jin , Xiu Faxian 
Published: July 2024

AbstractTransition-metal doped topological insulators have been widely explored since the observation of quantum anomalous Hall effect (QAHE). Subsequently, the magnetic (Pb,Sn)(Te,Se) was predicted to possibly possess a high-temperature QAHE state. However, the fundamental understanding of Cr-doping-induced ferromagnetism in this system remains unclear. Here, we report the stable ferromagnetism in the high-crystalline Cr-doped SnTe films. Upon Cr doping, the magnetoconductance unveils a crossover from weak antilocalization to weak localization. Further increasing the Cr concentration to Cr0.17Sn0.83Te introduces a strong ferromagnetism with a Curie temperature of ~140 K. We detected a sizable spin moment ms = 2.28 ± 0.23 μB/Cr and a suppressed orbital moment ml = 0.02 μB/Cr. Cr dopants prefer to substitute the Sn sites and behave as divalent cations, as indicated by the experimental results and density function theory calculations. The controllable growth of magnetic SnTe thin films provides enlightenment towards the high-temperature QAHE in magnetic TCIs for the desired dissipationless transport in electronics.
Refining the optimal CAF cluster marker for predicting TME-dependent survival expectancy and treatment benefits in NSCLC patients
Authors: Li Kai , Wang Rui , Liu Guo-Wei , Peng Zi-Yang , Wang Ji-Chang , Xiao Guo-Dong , Tang Shou-Ching , Du Ning , Zhang Jia , Zhang Jing , Ren Hong , Sun Xin , Yang Yi-Ping , Liu Da-Peng 
Published: July 2024

AbstractThe tumor microenvironment (TME) plays a pivotal role in the onset, progression, and treatment response of cancer. Among the various components of the TME, cancer-associated fibroblasts (CAFs) are key regulators of both immune and non-immune cellular functions. Leveraging single-cell RNA sequencing (scRNA) data, we have uncovered previously hidden and promising roles within this specific CAF subgroup, paving the way for its clinical application. However, several critical questions persist, primarily stemming from the heterogeneous nature of CAFs and the use of different fibroblast markers in various sample analyses, causing confusion and hindrance in their clinical implementation. In this groundbreaking study, we have systematically screened multiple databases to identify the most robust marker for distinguishing CAFs in lung cancer, with a particular focus on their potential use in early diagnosis, staging, and treatment response evaluation. Our investigation revealed that COL1A1, COL1A2, FAP, and PDGFRA are effective markers for characterizing CAF subgroups in most lung adenocarcinoma datasets. Through comprehensive analysis of treatment responses, we determined that COL1A1 stands out as the most effective indicator among all CAF markers. COL1A1 not only deciphers the TME signatures related to CAFs but also demonstrates a highly sensitive and specific correlation with treatment responses and multiple survival outcomes. For the first time, we have unveiled the distinct roles played by clusters of CAF markers in differentiating various TME groups. Our findings confirm the sensitive and unique contributions of CAFs to the responses of multiple lung cancer therapies. These insights significantly enhance our understanding of TME functions and drive the translational application of extensive scRNA sequence results. COL1A1 emerges as the most sensitive and specific marker for defining CAF subgroups in scRNA analysis. The CAF ratios represented by COL1A1 can potentially serve as a reliable predictor of treatment responses in clinical practice, thus providing valuable insights into the influential roles of TME components. This research marks a crucial step forward in revolutionizing our approach to cancer diagnosis and treatment.
Staging of post-settlement growth in the nudibranch Hypselodoris festiva
Authors: Hayashi Makiko , Nakano Hiroaki 
Published: July 2024

AbstractSea slugs of the family Chromodorididae (Nudibranchia, Gastropoda, Mollusca) have garnered attention by researchers and hobbyists alike for their bright and variable color patterns. However, the chromodorid life cycle has yet to be fully elucidated as there exist no reports of their rearing in the laboratory. Here, we report the rearing of Hypselodoris festiva from eggs to adults, where we categorized their post-settlement growth patterns from juvenile to adult stages. Body coloration appeared around 36 days, and organogenesis of vital adult organs began within 42 days after hatching. The anus of H. festiva was observed to change from a ventral to dorsal position during juvenile growth. Individuals reached sexual maturity after six months post-hatching, with successful mating and spawning observed ex situ. This study outlines comprehensive rearing methods and life cycle staging that could be applied to other chromodorid species. We propose H. festiva as a model organism for chromodorid research, with this research contributing to the progress of developmental and evolutionary research on sea slugs.
Circular dichroism of relativistically–moving chiral molecules
Authors: Whittam Mitchell R. , Zerulla Benedikt , Krstić Marjan , Vavilin Maxim , Holzer Christof , Nyman Markus , Rebholz Lukas , Fernandez-Corbaton Ivan , Rockstuhl Carsten 
Published: July 2024

Abstract
Understanding the impact of the relativistic motion of a chiral molecule on its optical response is a prime challenge for fundamental science, but it also has a direct practical relevance in our search for extraterrestrial life. To contribute to these significant developments, we describe a multi–scale computational framework that combines quantum chemistry calculations and full–wave optical simulations to predict the chiral optical response from molecules moving at relativistic speeds. Specifically, the effect of a relativistic motion on the transmission circular dichroism (TCD) of three life–essential biomolecules, namely, B–DNA, chlorophyll a, and chlorophyll b, is investigated. Inspired by previous experiments to detect interstellar chiral molecules, we assume that the molecules move between a stationary observer and a light source, and we study the rotationally averaged TCD as a function of the speed of the molecule.We find that the TCD spectrum that contains the signatures of the molecules shifts with increasing speed to shorter wavelengths, with the effects already being visible for moderate velocities.
Effect of nystagmus on VEP-based objective visual acuity estimates
Authors: Quanz Elisabeth V. , Kuske Juliane , Stolle Francie H. , Bach Michael , Heinrich Sven P. , Hoffmann Michael B. , Al-Nosairy Khaldoon O. 
Published: July 2024

AbstractIn order to determine the effect of nystagmus on objective visual acuity (VA) estimates, we compared subjective (VApsych) and objective (VEP, VAVEP) VA estimates in participants with nystagmus. For this purpose, 20 participants with nystagmus (NY) caused by idiopathic infantile nystagmus, albinism, achiasma or acquired nystagmus were recruited in this study. Estimates of BCVA (best corrected visual acuity) were determined psychophysically (VApsych; FrACT, Freiburg visual acuity test) and electrophysiologically (VAVEP; EP2000) according to ISCEV (International Society of Clinical Electrophysiology of Vision) guidelines. For each participant the eye with the stronger fixation instability [Nidek microperimeter (MP-1), Nidek Instruments] was included for further analysis. VApsych vs VAVEP were compared via paired t-tests and the correlation of the difference between VApsych and VAVEP (∆VA) vs the degree of fixation instability was tested with Pearson correlation (r). We found VAVEP to be better than VApsych [by 0.12 Logarithm of the Minimum Angle of Resolution (logMAR); mean ± standard error (SE) of VAVEP vs VApsych: 0.176 ± 0.06 vs. 0.299 ± 0.06, P = 0.017] and ∆VA to be correlated linearly with the degree of fixation instability (r2 = 0.21,p = 0.048). In conclusion, on average we report a small VA overestimation, around 1 line, for VAVEP compared to VApsych in NY. This overestimation depended on the magnitude of the fixation instability. As a rule of thumb, a reduction of the fixation probability in the central 4° from 100 to 50% leads on average to a VAVEP overestimation of around 0.25 logMAR, i.e. 2.5 lines.
Detection of Wuchereria bancrofti infection in mosquitoes in areas co-endemic with Brugia malayi in Balasore district, Odisha, India
Authors: Abraham Philip Raj , Ramalingam Balasubramaniyan , Mohapatra Priyadarshini , Krishnamoorthy Kaliannagounder , Hoti Sugeerappa Laxmanappa , Kumar Ashwani 
Published: July 2024

AbstractLymphatic filariasis (LF) is a crippling and disfiguring parasitic condition. India accounts for 55% of the world’s LF burden. The filarial parasite Wuchereria bancrofti is known to cause 99.4% of the cases while, Brugia malayi accounts for 0.6% of the issue occurring mainly in some pockets of Odisha and Kerala states. The Balasore (Baleswar) district of Odisha has been a known focus of B. malayi transmission. We employed molecular xenomonitoring to detect filarial parasite DNA in vectors. In six selected villages, Gravid traps were used to collect Culex mosquitoes and hand catch method using aspirators was followed for collection of mansonioides. A total of 2903 mosquitoes comprising of Cx. quinquefasciatus (n = 2611; 89.94%), Cx. tritaeniorhynchus (n = 100; 3.44%), Mansonia annuliferea (n = 139; 4.78%) and Mansonia uniformis (n = 53; 1.82%) were collected from six endemic villages. The species wise mosquitoes were made into 118 pools, each with a maximum of 25 mosquitoes, dried and transported to the laboratory at VCRC, Puducherry. The mosquito pools were subjected to parasite DNA extraction, followed by Real-time PCR using LDR and HhaI probes to detect W. bancrofti and B. malayi infections, respectively. Seven pools (6.66%) of Cx. quinquefasciatus, showed infection with only W. bancrofti while none of the pools of other mosquito species showed infection with either W. bancrofti or B. malayi. Although the study area is endemic to B. malayi, none of the vectors of B. malayi was found with parasite infection. This study highlights the ongoing transmission of bancroftian filariasis in the study villages of Balasore district of Odisha and its implications for evaluating LF elimination programme.
Towards pharmacokinetic boosting of phenoxymethylpenicillin (penicillin-V) using probenecid for the treatment of bacterial infections
Authors: Wilson Richard C. , Riezk Alaa , Arkell Paul , Ming Damien , Armiger Ryan , Latham Victoria , Gilchrist Mark J. , Märtson Anne-Grete , Hope William W. , Holmes Alison H. , Rawson Timothy M. 
Published: July 2024

AbstractIn the face of increasing antimicrobial tolerance and resistance there is a global obligation to optimise oral antimicrobial dosing strategies including narrow spectrum penicillins, such as penicillin-V. We conducted a randomised, crossover study in healthy volunteers to characterise the influence of probenecid on penicillin-V pharmacokinetics and estimate the pharmacodynamics against Streptococcus pneumoniae. Twenty participants took six doses of penicillin-V (250 mg, 500 mg or 750 mg four times daily) with and without probenecid. Total and free concentrations of penicillin-V and probenecid were measured at two timepoints. A pharmacokinetic model was developed, and the probability of target attainment (PTA) calculated. The mean difference (95% CI) between penicillin-V alone and in combination with probenecid for serum total and free penicillin-V concentrations was significantly different at both timepoints (total: 45 min 4.32 (3.20–5.32) mg/L p < 0.001, 180 min 2.2 (1.58–3.25) mg/L p < 0.001; free: 45 min 1.15 (0.88–1.42) mg/L p < 0.001, 180 min 0.5 (0.35–0.76) mg/L p < 0.001). There was no difference between the timepoints in probenecid concentrations. PTA analysis shows probenecid allows a fourfold increase in MIC cover. Addition of probenecid was safe and well tolerated. The data support further research into improved dosing structures for complex outpatient therapy and might also be used to address penicillin supply shortages.
Tag-free indoor fall detection using transformer network encoder and data fusion
Authors: Khan Muhammad Zakir , Usman Muhammad , Ahmad Jawad , Rahman Muhammad Mahboob Ur , Abbas Hasan , Imran Muhammad , Abbasi Qammer H. 
Published: July 2024

AbstractThis work presents a radio frequency identification (RFID)-based technique to detect falls in the elderly. The proposed RFID-based approach offers a practical and efficient alternative to wearables, which can be uncomfortable to wear and may negatively impact user experience. The system utilises strategically positioned passive ultra-high frequency (UHF) tag array, enabling unobtrusive monitoring of elderly individuals. This contactless solution queries battery-less tag and processes the received signal strength indicator (RSSI) and phase data. Leveraging the powerful data-fitting capabilities of a transformer model to take raw RSSI and phase data as input with minimal preprocessing, combined with data fusion, it significantly improves activity recognition and fall detection accuracy, achieving an average rate exceeding $$96.5\%$$

96.5
%

. This performance surpasses existing methods such as convolutional neural network (CNN), recurrent neural network (RNN), and long short-term memory (LSTM), demonstrating its reliability and potential for practical implementation. Additionally, the system maintains good accuracy beyond a 3-m range using minimal battery-less UHF tags and a single antenna, enhancing its practicality and cost-effectiveness.
Additive positive effect of warming and elevated nitrogen deposition on Sphagnum biomass production at mid-latitudes
Authors: Oishi Yoshitaka 
Published: July 2024

AbstractGlobal warming and increased atmospheric nitrogen (N) deposition can adversely impact Sphagnum moss populations and ecological functions in peatlands. Based on the anticipated increases in temperature and N levels at global scale, we investigated the effects of simultaneous warming and N treatment on growth and ecophysiological activity of Sphagnum papillosum, a predominant moss at mid-latitudes, utilizing a growth chamber experiment. Warming treatments increased the maximum yield of photosystem II (Fv/Fm) of S. papillosum while decreasing the stable carbon isotope ratio. However, warming treatment alone did not cause significant changes in the biomass increase from that of the control. Regarding N treatment, the low N treatment decreased Fv/Fm under the current temperature but did not affect the biomass increase. In contrast to these results, a simultaneous warming and high N treatment significantly enhanced the biomass production compared to that of the control, exhibiting additive effect of warming and high N treatment on Sphagnum biomass production. These responses were attributed to the improved photosynthetic performances by warming and N treatment. The results of this study contribute to the prediction of Sphagnum responses to warming and changes in N deposition.
Modelling reveals the effect of climate and land use change on Madagascar’s chameleons fauna
Authors: Mondanaro Alessandro , Di Febbraro Mirko , Castiglione Silvia , Belfiore Arianna Morena , Girardi Giorgia , Melchionna Marina , Serio Carmela , Esposito Antonella , Raia Pasquale 
Published: July 2024

AbstractThe global biodiversity crisis is generated by the combined effects of human-induced climate change and land conversion. Madagascar is one of the World’s most renewed hotspots of biodiversity. Yet, its rich variety of plant and animal species is threatened by deforestation and climate change. Predicting the future of Madagascar’s chameleons, in particular, is complicated by their ecological rarity, making it hard to tell which factor is the most menacing to their survival. By applying an extension of the ENphylo species distribution model algorithm to work with extremely rare species, we find that Madagascar chameleons will face intense species loss in the north-western sector of the island. Land conversion by humans will drive most of the loss, and will intersect in a complex, nonlinear manner with climate change. We find that some 30% of the Madagascar’s chameleons may lose in the future nearly all their habitats, critically jeopardizing their chance for survival.
Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family
Authors: Kim Youngchang , Lee Seung Hwan , Gade Priyanka , Nattermann Maren , Maltseva Natalia , Endres Michael , Chen Jing , Wichmann Philipp , Hu Yang , Marchal Daniel G. , Yoshikuni Yasuo , Erb Tobias J. , Gonzalez Ramon , Michalska Karolina , Joachimiak Andrzej 
Published: July 2024

Abstract2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, condenses formyl-CoA with aldehydes or ketones. The one-carbon elongation biochemistry based on HACL/S has enabled the use of molecules derived from greenhouse gases as biomanufacturing feedstocks. We investigated several HACL/S family members with high activity in the condensation of formyl-CoA and aldehydes, and distinct chain-length specificities and kinetic parameters. Our analysis revealed the structures of enzymes in complex with acyl-CoA substrates and products, several covalent intermediates, bound ThDP and ADP, as well as the C-terminal active site region. One of these observed states corresponds to the intermediary α–carbanion with hydroxymethyl-CoA covalently attached to ThDP. This research distinguishes HACL/S from related sub-families and identifies key residues involved in substrate binding and catalysis. These findings expand our knowledge of acyloin-condensation biochemistry and offer attractive prospects for biocatalysis using carbon elongation.
Characteristics of the vegetable oil debate in social-media and its implications for sustainability
Authors: Candellone Elena , Aleta Alberto , Ferraz de Arruda Henrique , Meijaard Erik , Moreno Yamir 
Published: July 2024

AbstractThe global production and consumption of vegetable oils have sparked wide-ranging and often emotive discussions on sustainable development, especially on social media. Here we analyze over 20 million tweets related to vegetable oils to explore the key factors shaping public opinion. Coconut, olive, and palm oils dominate social media discourse not proportionally to their global production. Olive and palm oil discussions remarkably correlate with Twitter’s (now X) growth, while coconut shows more bursts of activity. Discussions around coconut and olive oils primarily focus on health, beauty, and food, while palm oil draws attention to pressing environmental concerns. Virality is related to environmental issues and negative connotations. In the context of the Sustainable Development Goals, this study highlights the multifaceted nature of the vegetable oil debate and its disconnection from scientific discussions. Our research sheds light on the power of social media in shaping public perception, providing insights into sustainable development strategies.