bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombotic and neuropsychiatric sequelae in post-coronavirus disease 2019 end-stage renal disease patients on maintenance hemodialysis
Authors: El-Shinnawy Howayda A.E. , Abd El-Aziz Haitham E. , Elsharabasy Reem M. , El Nagar Zeinab M. , Ahmed Gharib Ahmed H. , Abdelnasier Mostafa A. 
Published: July 2024

Background
End-stage renal disease (ESRD) patients on maintenance hemodialysis (MHD) are highly vulnerable to severe manifestations of coronavirus disease 2019 (COVID-19) as increased risk of thromboembolic disease and worsened neuropsychiatric status.

Aim
To assess the long-term thrombotic and neuropsychiatric sequelae of severe acute respiratory syndrome corona virus 2 in post-COVID-19 ESRD patients on MHD.

Patients and methods
We followed for 12 months, 35 clinically stable HD patients on MHD who were confirmed or highly suspected for COVID-19 by positive severe acute respiratory syndrome corona virus 2 RT-PCR and/or high probability on high-resolution computed tomography chest imaging. We recorded demographics, HD and COVID-19 related data, thromboembolic history, and psychiatric history. We recorded baseline and follow-up complete blood count with differential counts, D-dimer, prothrombin time, international normalized ratio, and high-resolution computed tomography chest findings. We assessed post-COVID-19 neuropsychiatric sequelae using the Arabic versions of Hamilton’s depression rating scale and Taylor’s manifest anxiety scale.

Results
Total leukocytic count, lymphocytes, and platelets were significantly lower during infection than preinfection, 6 months, and 1-year postinfection (P<0.001, P=0.003, P=0.014, respectively). Six months after infection, d-dimer levels were higher than normal values. The incidence of vascular access thrombosis was 25.7%. The scores of Hamilton’s depression rating scale and Taylor’s manifest anxiety scale were high [25 (interquartile range; 17–28) and 26 (interquartile range; 19–33)], respectively, and the prevalence of depression and anxiety symptoms were 94.3 and 85.7%, respectively.

Conclusions
During infection, ESRD patients showed significantly lower total leukocytic count, lymphocytes, and platelets than preinfection, 6 months, and 1-year postinfection. They had high levels of d-dimer 6 months postinfection and a high risk for vascular access thrombosis. Their psychological wellbeing was markedly impaired by the pandemic resulting in depression and anxiety.
Lymphoid markers as predictors of adult acute myeloid leukemia prognosis
Authors: Said Rasha Magdy Mohamed , Moussa Mohamed Mahmoud Metwally , Samra Mohamed Abdel-Mooti Mohamed , Abdalla NourElhoda Hussien , Khalafallah Asmaa Ebaid , Hafez Heba Mohamed Saber 
Published: July 2024

Background
Acute myeloid leukaemia (AML) constitutes the most prevalent aggressive leukaemia in adults, with uncontrolled proliferation of immature myeloid cells and a variety of clinical manifestations. Whereas most AML patients respond to chemotherapy initially, half of all patients relapse within 5 years of being diagnosed.

Aim and objectives
The present study aimed to investigate the prognostic value of co expression of lymphocytes markers in patients with acute myeloid leukemia as regarding clinical outcome and survival.

Patients and methods
The present study was enrolled at Hematology Unit at Nasser Institute Hospital. This is a retrospective study done on (50) patients aged from 18 to 65 years, completion of treatment (or part of treatment undertaken), and follow-up duration of at least six months after diagnosis.

Results
The present study results showed a statistically significant difference between patients who achieved complete remission and those who relapsed or were refractory to treatment in the lymphoid markers CD7 and CD19. CD7 was the most frequent lymphoid marker. The lymphoid marker CD4 was associated with a higher complete remission rate. CD19 was associated with the highest relapse rate.

Conclusion
CD7 was the most frequent lymphoid marker. The lymphoid marker CD4 was associated with a higher complete remission rate compared to CD7, CD5, CD2 and CD19; While CD19 was associated with the highest relapse rate
The Impact of Self-Care Recommendations with and without Tilt-Training on Quality of Life in Children and Adolescents with Vasovagal Syncope: A Randomized Clinical Trial
Authors: Ahmadi Alireza , Sabri Mohammad Reza , Navabi Zohreh Sadat , Dehghan Bahar , Taheri Marzieh , Mahdavi Chehre 
Published: July 2024

Abstract

Background:
Syncope is among the most common paroxysmal disorders in children and adolescents. Vasovagal syncope is the most common syncope in children and adolescents. The aim of this study was to evaluate the impact of self-care recommendations with and without tilt training on the Quality of Life (QoL) of children and adolescents with syncope.

Materials and Methods:
This randomized controlled clinical trial was conducted in Isfahan, Iran, from April 2017 to June 2021 and included 120 patients with syncope. Eligible children and adolescents (aged 6–18 years) who met inclusion criteria were recruited by the simple sampling method and then assigned randomly into two groups. The intervention group (n = 60) received routine self-care recommendations such as dietary advice, behaviors to prevent syncope, and counter-pressure maneuvers along with tilt training, while the control group (n = 60) received self-care recommendations without tilt training. The education training included two face-to-face sessions, each of which lasted for 45–60 min. Then, both groups were followed up by telephone (once a month) for six months. A researcher-made self-care questionnaire and Pediatric Quality of Life Inventory (PedsQL™ 4.0) were completed for both groups before and after the intervention. Data were analyzed using descriptive and inferential statistical methods.

Results:
The Wilcoxon test results showed a significant difference in the mean scores of physical functioning, emotional functioning, social functioning, school functioning, psychosocial functioning, understanding of health, and total QoL in the intervention and control groups before and after the intervention (p < 0.05). Also, the paired t-test results showed a significant difference in the mean scores of self-care domains and total self-care in the intervention and control groups before and after the intervention (p < 0.05).

Conclusions:
Self-care recommendations with and without tilt training can improve QoL in children and adolescents with syncope.
“Growth under pressure”: The Experience of COVID-19 ICU Nurses - A Qualitative Study
Authors: Saidkhani Vahid , Asadizaker Marziyeh , Rokhafrooz Dariush , Molavynejad Shahram , Fakhri Ahmad 
Published: July 2024

Abstract

Background:
As an epidemic, COVID-19 has brought a new shock to the world’s healthcare system. The crisis caused by this disease and the prolonged involvement of communities and healthcare systems have intensified the duties and psychological burden of nurses. The current study aimed to explain the experience of ICU nurses during the COVID-19 crisis.

Materials and Methods:
The present study was conducted using conventional content analysis in 2021. Twenty nurses of the COVID-19 ICU of Ahvaz hospitals were selected by purposive sampling. The main method of data collection was semistructured interview. The process of data analysis was done based on Granheim and Lundman’s approach using MAXQDA-2020. For the scientific rigor of the findings, Guba and Lincoln’s four criteria were abided by. The COREQ (Consolidated Criteria for Reporting Qualitative Research) checklist was used to ensure the study met the recommended standards of qualitative data reporting.

Results:
After data analysis, 22 subcategories, eight categories, and one theme (growth under pressure) were extracted. The eight main categories included (psychological crisis, physical exhaustion, family conflicts, complex care, professional development, expertise, life enrichment, and full support).

Conclusions:
Despite the pressures that ICU nurses faced during the COVID-19 pandemic, they were able to grow by benefiting from positive experiences. These findings can lead to the development and implementation of effective interventions to improve adaptation strategies of nurses, especially those working in the intensive care unit, during the COVID-19 and other future crises.
Explaining the Components of Resilience in Patients with Chronic Pain: A Qualitative Content Analysis
Authors: Haghshenas Hajar , Shaygan Maryam , Pasyar Nilofar , Rambod Masoume 
Published: July 2024

Abstract

Background:
Resilience is a psychological trait and a protective factor that plays a vital role in coping with Chronic Pain (CP). Despite its importance, research has yet to fully clarify the concept and components of resilience in patients with CP. Accordingly, the present study aims to explain the components of resilience in patients with CP.

Materials and Methods:
The current qualitative study used a conventional content analysis methodology. The research population included all patients with CP who were referred to clinics affiliated with Shiraz University of Medical Sciences (south of Iran) from August 2021 to August 2022. Participants were selected using the purposive sampling method. In-depth semi-structured interviews were conducted with 20 participants to collect information. Data analysis was conducted using MAXQDA 2020 software in conjunction with data collection efforts.

Results:
Generally, in the current study, 30 sub-sub-categories, 11 sub-categories, and five main categories were extracted as components of resilience in patients with CP. The main categories of resilience against CP included the following: 1. emotional self-regulation, 2. psychological flexibility, 3. self-care, 4. appeal to religion–spirituality, and 5. internal resources and individual competencies.

Conclusions:
The present study highlights the different physical, mental, and religious-spiritual strategies that may contribute to resilience against pain. The resilience components identified in this study provide a foundation for healthcare professionals, particularly nurses, to design and implement diverse pain management strategies that enhance adjustment to CP conditions.
Parental concerns about oral health of children: Is ChatGPT helpful in finding appropriate answers?
Authors: Gugnani Neeraj , Pandit Inder Kumar , Gupta Monika , Gugnani Shalini , Kathuria Simran 
Published: July 2024

ABSTRACT

Introduction:
Artificial intelligence (AI) is becoming an important part of our lives owing to increased data availability and improved power of computing. One of the recently launched modalities of AI, ChatGPT, is being enormously used worldwide for different types of tasks. In medical context, its use is being explored for clinical queries, academia, research help, etc. Further, literature suggests that parents seek information about health of their children using different Internet resources and would surely turn toward ChatGPT for the same, as this chatbot model is easy to use, generates “one” response, and is available without any subscription. ChatGPT generates a response using text cues and applying different algorithms on prepublished literature but is still in its naïve state; hence, it is imperative to validate the generated responses. Accordingly, we planned this study to determine the clarity, correctness, and completeness of some Frequently asked questions (FAQs) about child’s oral health, from a mother’s perspective.

Methods:
The study design was a vignette-based survey and included a set of 23 questions, for which ChatGPT was interviewed from the perspective of an imaginary parent. The answers responded by ChatGPT were copied “verbatim,” and a Google survey form was designed. The survey form was validated and then sent to 15 pediatric dentists, and the responses were mainly collected on the Likert’s scale with a provision of one open-ended question aiming to determine “what they would have added” to this generated response as an expert in the field.

Results:
The responses on Likert’s scale were condensed and values ≥4 were considered ‘adequate and acceptable’ while scores ≤3, were considered ‘inadequate’. The generated responses and comments mentioned by different respondents in the open-ended question were critiqued in reference to the existing literature.

Conclusion:
Overall, the responses were found to be complete and logical and in clear language, with only some inadequacies being reported in few of the answers.
A comparative evaluation of intraperitoneal bupivacaine alone and bupivacaine with dexmedetomidine for post-operative analgesia following laparoscopic cholecystectomy
Authors: Bhatia Upasna , Khanbhaiwala Fatema Burhan , Prajapati Nihal , Atodaria Ami , Sutariya Viren , Bamania Hardik 
Published: July 2024

Abstract

Introduction:
Intraperitoneal instillation of local anaesthetic agents alone or in combination with opioids, α2 agonists such as Dexmedetomidine have been found to reduce postoperative pain following laparoscopic cholecystectomy. The study was designed to compare the better drug among Bupivacaine alone and Bupivacaine with Dexmedetomidine with respect to their analgesic efficacy and safety profile. in patients undergoing laparoscopic cholecystectomy.

Patients and Methods:
The study was carried out on sixty patients of the American Society of Anaesthesiologists (ASA) physical status I-II of either sex with ages ranging from 18 to 60 years posted for elective laparoscopic cholecystectomy under General Anaesthesia, equally divided into two groups, randomly allocated to one of the Groups using the table of randomization. Group B received Intraperitoneal Bupivacaine 40 ml 0.25% +5 ml normal saline and Group BD received Intraperitoneal Bupivacaine 40 ml 0.25% + Dexmedetomidine1 μg/kg diluted in 5 ml Normal saline.

Results:
The mean heart rate and blood pressure (systolic, diastolic and mean) readings were significantly lower in Group BD than in Group B. The mean duration of analgesia in our study was longer in Group BD (7.5 ± 0.73 hours) when compared to Group B (5.9 ± 0.55 hours) with p-value & 0.0001 and CI 1.27 to 1.9, which was statistically significant. However, the post-operative analgesic requirement (rescue/demand) in Group B was clinically earlier and statistically significant as compared to Group BD. Postoperative VAS score ≥3 was considered the benchmark for providing rescue analgesia in the form of injection of Diclofenac 75 mg IV. In our study, we observed the pain scores via VAS/NRS at 30 min, 1 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h, 14 h, 16 h, 18 h, 20 h, 22 h and 24 h postoperatively. A comparison of pain scores from 30 min to 10hrs postoperatively showed a significant difference in both Groups with Group B having significantly higher VAS scores and lower VAS scores with Group BD.

Conclusions:
Our study suggests that there is a shorter duration of action of 0.25% Bupivacaine alone as compared to 0.25% Bupivacaine + Dexmedetomidine. Since the laparoscope is still inside the abdominal cavity the drugs are easy to administer with no adverse effects and with a good safety profile because of the visualization of drug deposition in the right place. Intraperitoneal instillation of Bupivacaine with Dexmedetomidine for postoperative analgesia was very promising as a part of multimodal analgesia in laparoscopic cholecystectomy.
Risk factors of focal maculopathy in patients with type 2 diabetes mellitus with hard exudates: A hospital-based case–control study
Authors: Patra Rajkumar , Bhat Vinayak Ganesh , Goru Krishna Babu , Rao N. Lakshmana 
Published: July 2024

Abstract

Background:
Dyslipidemia and hard exudates of the retina have an intricate association. Increased lipid levels cause increased hard exudates. Many studies found dyslipidemia as an independent risk factor for the development of hard exudates in maculopathy.

Objectives:
The objective of this study was the association between dyslipidemia and the presence of hard exudates among focal maculopathy patients with and without hard exudates.

Materials and Methods:
This was a hospital-based case–control study. This study included 60 patients with focal maculopathy in type 2 diabetes mellitus (DM) with hard exudates. Sixty patients with Focal maculopathy in type 2 DM without hard exudates were taken as control.

Results:
Dyslipidemia was significantly seen (P < 0.05) in cases compared to participants. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and very LDL-C were significantly higher in cases compared to controls. High-density lipoprotein cholesterol (HDL-C) had the opposite outcome. HDL-C was significantly lower in cases compared to controls.

Conclusion:
Dyslipidemia was a strong risk factor for the formation of hard exudates in the macula. An increase in lipid levels increased the hard exudates concentration in the macula and retina.
Morbidity pattern of musculoskeletal disorders among school children in a selected ward of urban Bengaluru using pediatric Gait, Arms, Legs, and Spine screening tool
Authors: Kumar M. Shashi , Seema P. , Anil N. S. , Deepthi R. , Achala P. 
Published: July 2024

AbstractBackground:Musculoskeletal disorders (MSDs) among children are common globally and in India with the prevalence ranging from 4% to 15%. Musculoskeletal symptoms can be due to trauma or growing pains or symptoms of potentially life-threatening conditions such as malignancy, sepsis, and autoimmune disorders. With their indefinite onset and long latent period, early detection of these disorders and prompt treatment reduce the severity of outcomes; hence, screening is necessary.Objective:The objective of this study was to estimate the occurrence and describe the morbidity patterns of MSDs among school children in a selected school cluster of urban Bengaluru using the pediatric Gait, Arms, Legs, and Spine (pGALS) screening tool.Methods:A cross-sectional study was done, which included all the students of one randomly selected school cluster in one ward of urban Bengaluru. The total number of students was 260; 37 students did not get their parental consent, and 29 students were chronically absent. The pGALS tool has demonstrated an excellent sensitivity (around 97%) and specificity (around 98%) at all joints with high acceptability among children and parent/guardian and across cultures.Results:The overall occurrence of MSDs based on the pGALS tool among school children was 46.9% (91/194). Males were the most affected than females (males: 51.6% and females: 48.4%). Children in the age group of 10–15 years were most affected by MSDs (51.6%).Conclusion:The prevalence of MSDs is high among school-going children based on the pGALS screening tool, and this may be due to a recent sports event.
Comparison of the effect of 2 mL versus 3 mL sub-Tenon xylocaine injection on akinesia and analgesia in cataract patients at the University of Ilorin Teaching Hospital, Nigeria
Authors: Biola Tota-Bolarinwa T. , Grace Adepoju F. , Dupe Ademola-Popoola S. 
Published: July 2024

PURPOSE:
Sub-Tenon anesthesia is a form of local anesthetic techniques used in ophthalmic procedures, especially in cataract surgery. Few studies in our environment have reported the effects of sub-Tenon anesthesia on akinesia and analgesia as well as optimum volumes of anesthetic agents that are required for effective analgesia and akinesia. The objective of this study is to determine and compare the level of analgesia and akinesia and the effect of ocular compressions after sub-Tenon injection of 2 mL versus 3 mL of xylocaine among patients booked for cataract surgery in the University of Ilorin Teaching Hospital (UITH).

METHODS:
A cross-sectional comparative study among cataract patients booked for surgery in the Department of Ophthalmology at UITH was carried out from March 2017 to August 2017. A total of 200 cataract patients that met the inclusion criteria were recruited into the study over 6 months. Lists of cataract patients booked for surgery formed the sampling frame. Questionnaires were administered to obtain information on sociodemographic, ocular symptoms, and other histories. Visual acuity was checked, and ocular examination was done with a pen-torch, ophthalmoscope, and slit-lamp examination with 78D. Tonometry and optic nerve assessments were done to exclude any patient with preexisting glaucoma or suspicious disc. About 200 patients were randomly allocated into one of two volume groups (Group 1 had 2 mL sub-Tenon xylocaine injection whereas Group 2 had 3 mL); level of analgesia and akinesia was checked 12 min and 15 min, respectively.

RESULTS:
The age range was 20–107 years; mean age for Group 1 was 63.8 ± 12.64, whereas the mean age of Group 2 was 64.14 ± 14.14. There was a slight female preponderance given a M:f of 1:1.4 and more than half of the patients presented with right eye (RE) cataract. Levels of analgesia 12 min after sub-Tenon injections in both groups were similar. However, two patients were found to have severe pain in Group 1, and no patients had severe pain in Group 2. The level of akinesia which was assessed 15 min after injection in both groups was found to be significantly better in Group 2.

CONCLUSION:
There was a slight female preponderance with about two-third of the total patients being female and the percentage of females who had no pain was more than the male, more than 50% of the patients had RE cataracts. Sub-Tenon anesthesia whether with 2 mL or 3 mL led to a statistically significant rise in intraorbital pressure (IOP); however, with ocular compression, the IOP was found to decrease below the preinjection pressure in both groups. Levels of analgesia were similar in the two groups, whereas akinesia was statistically better in the group that had 3 mL injection.
Pengaruh Celebrity Worship Terhadap Perilaku Impulsive Buying pada Penggemar Pembeli Merchandise Jaemin NCT Dream
Authors: Ananda Hana Nurislami , Arpandy Ghea Amalia , Ariani Lita 
Published: July 2024

Indonesia memiliki penggemar K-Pop dengan persentase 23% yang artinya masyarakat di Indonesia merupakan salah satu penggemar K-Pop terbanyak di dunia. Jaemin merupakan Most Popular Member NCT Dream di Indonesia yang memiliki banyak basis penggemar. Perilaku impulsive buying merupakan kebiasaan pembelian tanpa perencanaan yang dilakukan oleh konsumen secara spontan. Penelitian ini dengan tujuan untuk menganalisis apakah terdapat pengaruh pada celebrity worship terhadap perilaku impulsive buying. Penelitian ini berjenis penelitian kuantitatif dengan metode penelitian yang menggunakan metode korelasional. Sampel pada penelitian ini sebanyak 125 responden. Teknik analisis data dalam penelitian ini menggunakan analisis regresi sederhana. Berdasarkan hasil analisis data taraf signifikansi yaitu P=0,000 (P<0,05) dengan nilai R square 0.222 dan berkorelasi sebesar 0.472 (P < 0,001). Hal ini menunjukkan bahwa celebrity worship memiliki pengaruh positif secara signifikan terhadap impulsive buying pada penggemar pembeli merchandise Jaemin NCT Dream, sehingga dapat diartikan bahwa semakin tinggi celebrity worship maka akan semakin tinggi juga perilaku impulsive buying dan sebaliknya semakin rendah celebrity worship maka akan semakin rendag juga perilaku impulsive buying dan sebaliknya semakin rendah celebrity worship maka akan semakin rendag juga perilaku impulsive buying.