bluuebunny/crossref_metadata_2025_split huggingface dataset:
EGFR mutations detected on cytology samples by a centralized laboratory reliably predict response to gefitinib in non–small cell lung carcinoma patients
Authors: Malapelle Umberto , Bellevicine Claudio , De Luca Caterina , Salatiello Maria , De Stefano Alfonso , Rocco Danilo , de Rosa Nicla , Vitiello Fabiana , Russo Stefania , Pepe Francesco , Iaccarino Antonino , Micheli Pietro , Illiano Alfonso , Carlomagno Chiara , Piantedosi Franco Vito , Troncone Giancarlo 
Published: June 2013

BACKGROUNDEpidermal growth factor receptor (EGFR) mutations are reliably detected by referral laboratories, even if most lung cancer cytology specimens sent to such laboratories contain very few cells. However, EGFR mutations may be distributed heterogeneously within tumors, thereby raising concerns that mutations detected on cytology are not representative of the entire tumor and, thus, are less reliable in predicting response to tyrosine kinase inhibitor (TKI) treatment than mutations detected on histology. To address this issue, the authors reviewed their clinical practice archives and compared the outcome of TKI treatment among patients who were selected by cytology versus patients who were selected by histology.METHODSFrom July 2010 to July 2012, 364 cytology samples and 318 histology samples were received. Exon 19 deletions and the L858R point mutation in exon 21, detected by fragment assay and TaqMan assay, respectively, were confirmed by direct sequencing; discrepancies were resolved by cloning polymerase chain reaction products. The response rate (RR) and progression‐free survival (PFS) at 12 months (range, 3‐34 months) were evaluable in 13 EGFR‐mutated patients who were selected for treatment by cytology and 13 patients who were selected by histology.RESULTSThe mutation rate was similar in histology samples (8.5%) and cytology samples (8.8%). The RR (54%) and PFS (9.2 months) were similar in histologically selected patients and cytologically selected patients (RR, 62%; PFS, 8.6 months; P = .88). The disease control rate (responsive plus stable disease) was 92% in histologically selected patients and 100% in cytologically selected patients.CONCLUSIONSEGFR mutations detected on cytology specimens by a centralized laboratory can predict TKI treatment response equally well as mutations identified on histology samples. Cancer (Cancer Cytopathol) 2013;121:552–560. © 2013 American Cancer Society.
The effect of rifampin on the pharmacokinetics of sirolimus in healthy volunteers
Authors: Tortorici Michael A. , Matschke Kyle , Korth‐Bradley Joan M. , DiLea Cliff , Lasseter Kenneth C. 
Published: June 2013

AbstractSirolimus, metabolized primarily by intestinal and hepatic CYP3A4, is a substrate for P‐glycoprotein. CYP3A4 inducers would be expected to decrease sirolimus exposure. This open‐label, nonrandomized study investigated effects of CYP3A4 induction, by rifampin, on sirolimus pharmacokinetics. Healthy volunteers received sirolimus 20 mg on day 1. After washout period, multiple 600‐mg rifampin doses were administered daily for 14 days. On day 9, one 20‐mg sirolimus dose was administered after an overnight fast (≥10 hours). Whole blood samples for sirolimus collected for 144 hours after each dose were analyzed by liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameters, assessed using noncompartmental methods, were compared using analysis of variance. Geometric mean ratios of Cmax and AUCinf were 29% (90% CI: 26, 32%) and 18% (90% CI: 16, 21%), respectively, with rifampin co‐administration versus sirolimus alone. Corresponding decreases in Cmax and AUC were 71% and 82%, respectively, which would likely cause trough concentrations to fall below the recommended therapeutic range. Mean CL/F increased approximately fivefold with rifampin versus sirolimus alone. Co‐administering sirolimus and potent CYP3A inducers is not recommended. If co‐administration is necessary, dose adjustment and concentration monitoring should be conducted.
Study on Nanobubble Generation: Saline Solution/Water Exchange Method
Authors: Liu Minghuan , Zhao Wanchen , Wang Shuo , Guo Wen , Tang Yuzhao , Dong Yaming 
Published: June 2013

AbstractIn a recently introduced method for nanobubble generation, water is replaced with NaCl solution. It has the same mechanism as alcohol/water exchange: a liquid of higher gas solubility is used to replace one of lower gas solubility. Herein, the opposite process is realized by replacement of saline solutions with water. Interestingly, nanobubbles are also observed by AFM when different concentrations and valences of saline liquids are employed.
New Tools for Investigating Electromagnetic Hot Spots in Single‐Molecule Surface‐Enhanced Raman Scattering
Authors: Willets Katherine A. 
Published: June 2013

AbstractSurface‐enhanced Raman scattering (SERS) is quickly growing as an analytical technique, because it offers both molecular specificity and excellent sensitivity. For select substrates, SERS can even be observed from single molecules, which is the ultimate limit of detection. This review describes recent developments in the field of single‐molecule SERS (SM‐SERS) with a focus on new tools for characterizing SM‐SERS‐active substrates and how they interact with single molecules on their surface. In particular, techniques that combine optical spectroscopy and microscopy with electron microscopy are described, including correlated optical and transmission electron microscopy, correlated super‐resolution imaging and scanning electron microscopy, and correlated optical microscopy and electron energy loss spectroscopy.
Towards High Conductivity in Anion‐Exchange Membranes for Alkaline Fuel Cells
Authors: Li Nanwen , Guiver Michael D. , Binder Wolfgang H. 
Published: June 2013

AbstractQuaternized poly(2,6‐dimethylphenylene oxide) materials (PPOs) containing clicked 1,2,3‐triazoles were first prepared through CuI‐catalyzed “click chemistry” to improve the anion transport in anion‐exchange membranes (AEMs). Clicked 1,2,3‐triazoles incorporated into AEMs provided more sites to form efficient and continuous hydrogen‐bond networks between the water/hydroxide and the triazole for anion transport. Higher water uptake was observed for these triazole membranes. Thus, the membranes showed an impressive enhancement of the hydroxide diffusion coefficient and, therefore, the anion conductivities. The recorded hydroxide conductivity was 27.8–62 mS cm−1 at 20 °C in water, which was several times higher than that of a typical PPO‐based AEM (TMA‐20) derived from trimethylamine (5 mS cm−1). Even at reduced relative humidity, the clicked membrane showed superior conductivity to a trimethylamine‐based membrane. Moreover, similar alkaline stabilities at 80 °C in 1 M NaOH were observed for the clicked and non‐clicked membranes. The performance of a H2/O2 single cell assembled with a clicked AEM was much improved compared to that of a non‐clicked TMA‐20 membrane. The peak power density achieved for an alkaline fuel cell with the synthesized membrane 1a(20) was 188.7 mW cm−2 at 50 °C. These results indicated that clicked AEM could be a viable strategy for improving the performance of alkaline fuel cells.
Nutrient cycling in early coral life stages: Pocillopora damicornis larvae provide their algal symbiont (Symbiodinium) with nitrogen acquired from bacterial associates
Authors: Ceh Janja , Kilburn Matt R. , Cliff John B. , Raina Jean‐Baptiste , van Keulen Mike , Bourne David G. 
Published: June 2013

AbstractThe waters surrounding coral reef ecosystems are generally poor in nutrients, yet their levels of primary production are comparable with those reported from tropical rain forests. One explanation of this paradox is the efficient cycling of nutrients between the coral host, its endosymbiotic alga Symbiodinium and a wide array of microorganisms. Despite their importance for the animals' fitness, the cycling of nutrients in early coral life stages and the initial establishment of partnerships with the microbes involved in these processes has received little scrutiny to date. Nitrogen is an essential but limited nutrient in coral reef ecosystems. In order to assess the early nutrient exchange between bacteria and corals, coral larvae of the species Pocillopora damicornis were incubated with two coral‐associated bacteria (Alteromonas sp., or Vibrio alginolyticus), prelabeled with the stable nitrogen isotope 15N. The incorporation and translocation of nitrogen from Vibrio‐ and Alteromonas bacteria into P. damicornis coral larvae and specifically into the coral‐symbiotic Symbiodinium were detected by nanoscale secondary ion mass spectrometry (NanoSIMS). A significant increase in the amount of enriched 15N (two to threefold compared to natural abundance) was observed in P. damicornis larvae within 8 h of incubation for both bacterial treatments (one‐way ANOVA, F5,53 = 18.03, P = 0.004 for Alteromonas sp. and F5,53 = 18.03, P = 0.0001 for V. alginolyticus). These findings reveal that coral larvae acquire nutrients previously taken up from the environment by bacteria. The additional nitrogen may increase the survival rate and fitness of the developing coral and therefore contribute to the successful maintenance of coral reefs.
Highly Enantioselective Thiolysis of Prochiral Cyclic Anhydrides Catalyzed by Amino Alcohol Bifunctional Organocatalysts and Its Application to the Synthesis of Pregabalin
Authors: Yang Hong‐Jun , Xiong Fang‐Jun , Chen Xiao‐Fei , Chen Fen‐Er 
Published: June 2013

AbstractAsymmetric thiolysis of prochiral cyclic anhydrides was achieved with our developed chiral sulfonamide and squaramide bifunctional organocatalysts based on amino alcohol scaffolds. The corresponding thioesters were obtained in high yields with excellent enantioselectivities. The usefulness of this methodology was demonstrated in the enantioselective synthesis of pregabalin.
Practice‐oriented estimation of the seismic demand hazard using ground motions at few intensity levels
Authors: Bradley Brendon A. 
Published: June 2013

SUMMARYThis paper examines the calculation of the seismic demand hazard in a practice‐oriented manner via the use of seismic response analyses at few intensity levels. The seismic demand hazard is a more robust measure for quantifying seismic performance, when seismic hazard is represented in a probabilistic format, than intensity‐based assessments, which remain prevalent in seismic design codes. It is illustrated that, for a relatively complex bridge–foundation–soil system case study, the seismic demand hazard can be estimated with sufficient accuracy using as little as three intensity measure levels that have exceedance probabilities of 50%, 10% and 2% in 50 years which are already of interest in multi‐objective performance‐based design. Compared with the conventional use of the mean demand from an intensity‐based assessment(s), it is illustrated that, for the same number of seismic response analyses, a practice‐oriented ‘approximate’ seismic demand hazard is a more accurate and precise estimate of the ‘exact’ seismic demand hazard. Direct estimation of the seismic demand hazard also provides information of seismic performance at multiple exceedance rates. Thus, it is advocated that if seismic hazard is considered in a probabilistic format, then seismic performance assessment, and acceptance criteria, should be in terms of the seismic demand hazard and not intensity‐based assessments. Copyright © 2013 John Wiley & Sons, Ltd.
PRICING DISTORTIONS IN MEDICARE'S PHYSICIAN FEE SCHEDULE AND PATIENT SATISFACTION WITH CARE QUALITY AND ACCESS
Authors: Brunt Christopher S. , Jensen Gail A. 
Published: June 2013

ABSTRACTMedicare adjusts its payments to physicians for geographic differences in the cost of operating a medical practice, but the method it uses is imprecise. We measure the inaccuracy in its geographic adjustment factors and categorize beneficiaries by whether they live where Medicare's formula is favorable or unfavorable to physicians. Then, using the 2001–2003 Medicare Current Beneficiary Survey, we examine whether differences in physician payment generosity, that is, whether favorable or unfavorable, influence the satisfaction ratings Medicare seniors assign to their quality of care and access to services. We find strong evidence that they do. Many beneficiaries live in payment‐unfavorable areas and receive a less satisfying quality of care and less satisfying access to services than beneficiaries who live where payments are favorable to physicians. Copyright © 2013 John Wiley & Sons, Ltd.
DID REFORM OF THE NON‐GROUP HEALTH INSURANCE MARKET AFFECT THE DECISION TO BE SELF‐EMPLOYED? EVIDENCE FROM STATE REFORMS IN THE 1990s
Authors: Heim Bradley T. , Lurie Ithai Z. 
Published: June 2013

SUMMARYThis paper estimates whether state‐level implementation of community rating and guaranteed issue regulations in the non‐group health insurance market during the 1990s affected the decision of taxpayers to be self‐employed. Using a panel of tax returns that span 1987–2000, we find no statistically significant effect of the reforms on the propensity to be self‐employed overall, although we find evidence of an increase in self‐employment among older taxpayers and weaker evidence of decreases among younger cohorts. Copyright © 2013 John Wiley & Sons, Ltd.
Intensive care unit versus non–intensive care unit postoperative management of head and neck free flaps: Comparative effectiveness and cost comparisons
Authors: Arshad Hassan , Ozer Hatice Gulcin , Thatcher Aaron , Old Matthew , Ozer Enver , Agarwal Amit , Jafari Hosseinali , Birkheimer Danette , Basinger Heidi , Forest L. Arrick , Schuller David E. , Teknos Theodoros N. 
Published: June 2013

BackgroundDespite its widespread use, there is no consensus on the postoperative management in patients undergoing free flap reconstructions. We report the largest study comparing flap outcomes, morbidity, and cost in patients with head and neck cancer free flaps who recovered in the intensive care unit (ICU) versus a “specialty floor” setting.MethodsThis was a retrospective review of patients undergoing free flap surgery for head and neck defects over a 4‐year period. Patients before a certain date went to the ICU for immediate postoperative care and after to a non‐ICU setting. Postoperative medical and surgical complications and hospital charges were analyzed.ResultsPatients in the ICU group had a longer length of stay (LOS) and incurred greater hospital costs than the patients in the non‐ICU setting. There was no difference in the flap failure rate between the 2 groups.ConclusionConsideration should be given to a floor‐based postoperative management regimen for this patient population. © 2013 Wiley Periodicals, Inc. Head Neck 36: 536–539, 2014
Long‐term functional and survival outcomes after induction chemotherapy and risk‐based definitive therapy for locally advanced squamous cell carcinoma of the head and neck
Authors: Hutcheson Katherine A. , Lewin Jan S. , Holsinger F. Christopher , Steinhaus Ganene , Lisec Asher , Barringer Denise A. , Lin Heather Y. , Villalobos Sandra , Garden Adam S. , Papadimitrakopoulou Vali , Kies Merrill S. 
Published: June 2013

BackgroundThe purpose of this study was to evaluate long‐term outcomes after induction chemotherapy followed by “risk‐based” local therapy for locally‐advanced squamous cell carcinoma of the head and neck (SCCHN).MethodsForty‐seven patients (stage IV; ≥N2b) were enrolled in a phase II trial. Baseline and 24‐month functional measures included modified barium swallow (MBS) studies, oropharyngeal swallow efficiency (OPSE), and the MD Anderson Dysphagia Inventory (MDADI). Functional status was assessed at 5 years.ResultsFive‐year overall survival (OS) was 89% (95% confidence interval [CI], 81% to 99%). A nonsignificant 13% average reduction in swallowing efficiency (OPSE) was observed at 24 months relative to baseline (p = .191). MDADI scores approximated baseline at 24 months. Among 42 long‐term survivors (median, 5.9 years), 3 patients (7.1%) had chronic dysphagia. The rate of final gastrostomy dependence was 4.8% (2 of 42).ConclusionSequential chemoradiotherapy achieved favorable outcomes among patients with locally advanced SCCHN, mainly of oropharyngeal origin. MBS and MDADI scores found modest swallowing deterioration at 2 years, and chronic aspiration was uncommon in long‐term survivors. © 2013 Wiley Periodicals, Inc. Head Neck 36: 474–480, 2014
Using the PICCOLO with Parents of Children with a Disability
Authors: Innocenti Mark S. , Roggman Lori A. , Cook Gina A. 
Published: June 2013

ABSTRACTAll children benefit from positive parenting behaviors that support early child development. For a parent of a child with a disability, the child's characteristics and possible limitations can make positive parenting behaviors challenging, and yet, these interactions need to be a focus of early intervention to promote optimal family and child development. Family‐centered practice, which includes strengthening parenting skills, has been advocated by the early intervention field. Although early intervention programs realize the importance of supporting parent–child interaction as part of family‐centered practice, it has not been an emphasis of most early intervention programs. The lack of easy‐to‐use, psychometrically strong parenting measures is an issue in early intervention. The Parenting Interactions with Children: Checklist of Observations Linked to Outcomes (PICCOLO) provides a practical observation measure of parenting with young children. We tested the reliability and validity of this measure with parents of children with an identified disability. Early parenting behaviors predicted cognitive and language outcomes for children with an identified disability up to 9 years after the first assessment. The PICCOLO demonstrated strong reliability and both construct and predictive validity, and shows promise as a useful measure for practitioners working with parents who have a child with a disability.
Symptoms of Attention‐Deficit/Hyperactivity Disorder (ADHD) Moderate Suicidal Behaviors in College Students With Depressed Mood
Authors: Patros Connor H. G. , Hudec Kristen L. , Alderson R. Matt , Kasper Lisa J. , Davidson Collin , Wingate LaRicka R. 
Published: June 2013

ObjectiveCollege students with attention‐deficit/hyperactivity disorder‐related hyperactive/impulsive (HI) and/or inattentive (IA) symptoms may be at greater risk for suicidal behavior due to core and secondary symptoms that increase their potential to engage in behaviors that put them at risk for suicidal behavior. Consequently, the current study examined the moderating effect of combined HI/IA symptoms, in addition to independent HI and IA symptoms on the relationship between depressed mood and suicidal thoughts and behavior.MethodA sample of 1,056 undergraduate students (61.5% female, 96.4% aged 18–24 years) provided self‐report ratings of mood, suicidal behavior (thoughts, self‐harm, attempts, and need for medical attention), and current HI/IA symptoms.ResultsSignificant moderation effects were detected, such that greater HI/IA symptoms were associated with a stronger relationship between depressed mood and suicidal ideation and attempts, but not self‐harm. Current HI and IA symptoms significantly moderated the relationship between depressed mood and suicidal thoughts and suicide attempts, but did not moderate the relationship between depressed mood and self‐harm and need for medical attention.ConclusionsThe current findings suggest that the presence of combined HI/IA symptoms conveys increased suicide risk for depressed college students. Additionally, results suggest a complex relationship between independent HI and IA symptoms and severe suicidal outcomes.
A Qualitative Description of Female Veterans’ Deployment‐Related Experiences and Potential Suicide Risk Factors
Authors: Gutierrez Peter M. , Brenner Lisa A. , Rings Jeffrey A. , Devore Maria D. , Kelly Patricia J. , Staves Pamela J. , Kelly Caroline M. , Kaplan Mark S. 
Published: June 2013

ObjectiveA qualitative study among female Veterans from recent conflicts was conducted to explore the women's experiences and potential suicide risk factors according to the Interpersonal Psychological Theory of Suicide, including burdensomeness, failed belongingness, and acquired ability.MethodsThe presented paper is an extension of published work by Brenner et al. (2008) regarding mostly male combat Veterans. The methodology employed was qualitative descriptive with hermeneutic hues (Sandelowski, 2000). Interviews were conducted with 19 women, aged 24–52 years, all of whom had been deployed to combat zones in Iraq and/or Afghanistan.ResultsTranscripts were reviewed and themes emerged regarding women being a minority within their environment and deployment‐related stressors. These experiences seemed to influence participants’ views of the world and ways of coping.ConclusionsAmong the interviewed female Veterans, preliminary support was provided for Joiner's concepts. Therapeutic strategies for applying themes to clinical practice (e.g., peer support, family therapy, interventions aimed at increasing distress tolerance) are provided.
Generation of periodic signatures at Saturn through Titan's interaction with the centrifugal interchange instability
Authors: Winglee R. M. , Kidder A. , Harnett E. , Ifland N. , Paty C. , Snowden D. 
Published: June 2013

AbstractThe origin of the periodicities in the radio, plasma, and magnetic fields of Saturn has long been debated. Given the high degree of alignment of Saturn's dipole with its rotation axis, no strong rotational periodicities are expected. However, Cassini data demonstrated the existence of such periodicities not only in Saturn's kilometric radio emissions (SKR) but in the plasma and magnetic field signatures. It is shown that the development of the centrifugal interchange instability that originates from mass loading from the Enceladus torus contains information about the planetary rotation period. However, the planetary period is masked by high‐frequency components of the instability. The presence of Titan is shown to damp the high‐frequency components and enables the fundamental frequency near the planetary rotation frequency to grow at the expense of the high‐frequency components. As a result, the interchange instability is seen to change from one where five to seven large interchange fingers dominate to one where there are about three which cause the modulation of magnetospheric parameters near the planetary period. This modulation includes the movement of the magnetopause, the injection of energetic particles into the inner magnetosphere and the plasma density at high latitudes, both of which control SKR. Controlling factors on the frequency include Titan's drag on the plasma sheet which produces asymmetries between the Northern and Southern Hemispheres, solar wind conditions, and the density of the Enceladus plasma torus. The resultant magnetic perturbations are shown to have similar size and frequency as that seen in Cassini data.