bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of anxiety and depressive disorders in patients with idiopathic dystonia and functional movement disorder
Authors: Tolmacheva V. A. , Spektor E. D. , Romanov D. V. 
Published: August 2024

Introduction. Differential diagnosis of idiopathic and functional dystonia is often the cause of errors. The comparative severity of anxiety, depressive disorders and the level of somatization in idiopathic and functional dystonia has been poorly studied.Aim. To comparatively analyze the severity of anxiety, depressive disorders and the level of somatization in patients with idiopathic and functional dystonia.Materials and methods. The study included 178 patients with idiopathic dystonia, 32 patients – with functional dystonia, and the control group consisted of 50 people. The GAD-7 scale was used to assess the level of anxiety, PHQ-9 for depression, and SOMS for somatization. The EQ-5D scale was used to assess the quality of life.Results. There was a predominance of women patients in all groups. Patients with functional dystonia were younger than patients with idiopathic dystonia, and most of them were unmarried and unemployed (p < 0.001). In separate groups of patients with idiopathic and functional dystonia, elevated levels of anxiety (9.0 and 8.0) and depression (8.0 and 16.5) were observed compared to the control group (p < 0.001), while the severity of anxiety between idiopathic and functional dystonia did not differ significantly, and the severity of depression in functional dystonia was significantly higher (p < 0.001) than in patients with idiopathic dystonia. The results of the SOMS survey revealed a relative difference between the group and the maximum values in patients with functional dystonia – 22.0 (19.8; 24.0). According to the European Quality of Life Questionnaire, patients with functional dystonia had the lowest quality of life – 20.0 (10.0; 30.0).Conclusion. Patients with functional dystonia have a lower quality of life and higher levels of depression and somatization compared to patients with functional dystonia, as well as to the control group. These data can be additional criteria in the differential diagnosis of idiopathic and functional dystonia.
Treatment of functional neurological disorders by example of a patient with cardiac neurosis, tension headache, musculoskeletal pain and insomnia
Authors: Golovacheva V. A. , Golovacheva A. A. 
Published: August 2024

The article presents a clinical case of a patient with cardioneurosis, frequent episodic tension headaches involving the pericranial muscles, chronic musculoskeletal cervicalgia, thoracalgia, chronic insomnia and increased anxiety. The above disorders are listed among the most common reasons for seeking outpatient care from a neurologist. The majority of patients with these disorders are young people of working and reproductive age. For this reason, it is important to consider an effective, modern approach to the treatment of such patients in outpatient neurological settings. Treatment of this category of patients is quite a challenge that requires the expert knowledge, experience and attentive attitude of the doctor towards the patient. Difficulties in treating such patients are associated with the fact that they have misconceptions about their disease, catastrophic thinking about their symptoms, avoidance behaviours, unhealthy lifestyle and distress for a long time, increased emotional sensitivity to current events, and stressful events that preceded their disease. Despite the increased level of anxiety and the psychosomatic nature of the complaints, many patients refuse to consult a psychiatrist and take antidepressants in real neurological practice. The Sechenov University Clinic of Nervous Diseases offered the patient a comprehensive approach to the treatment that comprises awareness conversations, recommendations on sleep hygiene and lifestyle, the short-term use of Valocordin, cognitive-behavioural therapy, relaxation and mindfulness, and kinesiotherapy. The detailed clinical conversations with the patient and examination data allowed to identify all factors that provoked and supported cardioneurosis, pain syndromes, insomnia that was caused by stressful events in the anamnesis, misconceptions about her condition and treatment methods, catastrophizing of symptoms, erroneous strategies for overcoming pain, anxiety and insomnia, physical inactivity, prolonged static load. The treatment process included therapeutic dealing with all of the listed factors. The complex treatment resulted in a decrease in patient’s pain and cardioneurotic symptoms, improvement of her sleep and emotional state, and returning to her previous active lifestyle.
A Revolution in Healthcare: AI-powered Cancer Imaging
Authors: Kumar Gulshan , Verma Swati , Malviya Rishabha , Paliwal Sarvesh , Narayan Chaitanay Vinayak 
Published: August 2024

Abstract:
Diagnosing and successfully treating cancer remains to be a formidable challenge. Cancer
diagnosis by conventional methods is laborious and highly subjective, reliant on the knowledge
and experience of radiologists and pathologists. With the combination of AI and ML technologies,
cancer imaging has seen a paradigm change. Medical imaging like CT, MRI, and PET
scans may be analyzed using AIML algorithms and deep neural networks for characteristics and
patterns that might indicate malignancy. More precise diagnosis and tailored treatment programs
are possible with their aid in tumor segmentation and categorization. A type of artificial intelligence
that has shown promise in cancer detection is radiomics. One more key approach utilized in
AI-powered cancer detection is texture analysis. This technique entails analyzing the spatial organization
of pixel intensities in a picture. The genetic elements that contribute to the genesis and
progression of cancer are becoming better understood with the development of artificial intelligence
systems that can analyze genomic data in addition to medical imaging. This review article
delves into the revolutionary effects of AI and ML on cancer imaging, showcasing significant
progress, obstacles, and potential solutions. Early detection, diagnosis, and personalized treatment
methods are being transformed by these technologies, which are making use of the massive quantities
of medical data that are accessible. The result is an improvement in patient outcomes.
Development and Validation of a High-Performance Thin-Layer Chromatography Method for Simultaneous Qualitative and Quantitative Analysis of Scutellarin and Scutellarein in S. barbata D. Don
Authors: Pannu Arzoo , Goyal Ramesh K. 
Published: August 2024

Background:
S. barbata D. Don, a perennial herb from the Lamiaceae family, is renowned
for its medicinal properties, with scutellarin and scutellarein being key bioactive constituents.

Aim:
In this study, we present the development and validation of a High-Performance Thin-
Layer Chromatography (HPTLC) method for the simultaneous quantitative and qualitative
analysis of scutellarin and scutellarein in the hydroethanol extract of S. barbata D. Don.

Methods:
The chromatographic conditions were optimized using different solvent systems, and
validation was performed as per ICH guidelines.

Results:
The mobile phase comprising Ethyl acetate: methanol: formic acid: water (20: 2.7:
0.5: 2) and scanning wavelength set at 254 nm was optimized for study, resulting in distinct
and well-separated spots for scutellarin and scutellarein with Rf values of 0.31 and 0.96, respectively.
The method was rigorously validated to ensure reliability and reproducibility. Calibration
curves exhibited excellent linearity for both scutellarin (r² > 0.98) and scutellarein (r² >
0.99) over a concentration range of 10-30 μg/ml. The developed method underwent thorough
validation following ICH guidelines. Validation parameters included accuracy, limit of quantification,
limit of detection, linearity, precision, and recovery. The determined concentration of
scutellarin and scutellarein in the hydroethanolic extract of S. barbata D. Don was found to be
27.00 μg/mg and 20.16 μg/mg of extract, respectively.

Conclusion:
This proposed method demonstrates its utility for both qualitative and quantitative
analyses of scutellarin and scutellarein in the hydroethanolic extract of S. barbata D. Don, offering
a reliable and validated approach for quality control and standardization in the herbal
product industry.
Protective Effect of Carvacrol against Oxidative Damage in Aged Rats
Authors: Forqani Mohammad Amin , Akbarian Mahsan , Amirahmadi Sabiheh , Khorrami Mohammad Bagher , Hosseini Mahmoud , Forouzanfar Fatemeh 
Published: August 2024

Background:
Aging affects cellular functions and impairs tissue homeostasis. Carvacrol,
a polyphenolic compound, has been shown to exert a wide range of pharmacological effects,
such as antioxidant, anti-inflammatory, and anticancer characteristics.

Methods:
This investigation aimed to evaluate the effect of carvacrol in elderly male rats. Carvacrol
at a dose of 15 or 30 mg/kg was administrated daily per os for 60 days to aged rats. The liver,
heart, and kidney samples were taken for the analysis of oxidative stress markers. Serum samples
were used to evaluate liver enzymes (alanine transaminase (ALT) and aspartate aminotransferase
(AST)).

Results:
The levels of malondialdehyde (MDA) in the liver, heart, and kidney tissues of aged rats
were higher. Conversely, the level of thiol was lower in the mentioned tissues than in the young
control group.
The levels of MDA in the liver, heart, and kidney tissues of aged rats were significantly reduced by
carvacrol, which was accompanied by increased levels of total thiol. ALT and AST levels were
higher in the serum of aged rats than in the young control ones. Carvacrol decreased ALT and AST
levels in the serum of aged rats versus aged control rats.

Conclusion:
Carvacrol can be effective in protecting susceptible aged tissues and organs by increasing
antioxidant defenses and decreasing liver enzymes.
Leveraging Open-Source Large Language Models for Data Augmentation in Hospital Staff Surveys: Mixed Methods Study
Authors: Ehrett Carl , Hegde Sudeep , Andre Kwame , Liu Dixizi , Wilson Timothy 
Published: August 2024

Abstract

Background
Generative large language models (LLMs) have the potential to revolutionize medical education by generating tailored learning materials, enhancing teaching efficiency, and improving learner engagement. However, the application of LLMs in health care settings, particularly for augmenting small datasets in text classification tasks, remains underexplored, particularly for cost- and privacy-conscious applications that do not permit the use of third-party services such as OpenAI’s ChatGPT.

Objective
This study aims to explore the use of open-source LLMs, such as Large Language Model Meta AI (LLaMA) and Alpaca models, for data augmentation in a specific text classification task related to hospital staff surveys.

Methods
The surveys were designed to elicit narratives of everyday adaptation by frontline radiology staff during the initial phase of the COVID-19 pandemic. A 2-step process of data augmentation and text classification was conducted. The study generated synthetic data similar to the survey reports using 4 generative LLMs for data augmentation. A different set of 3 classifier LLMs was then used to classify the augmented text for thematic categories. The study evaluated performance on the classification task.

Results
The overall best-performing combination of LLMs, temperature, classifier, and number of synthetic data cases is via augmentation with LLaMA 7B at temperature 0.7 with 100 augments, using Robustly Optimized BERT Pretraining Approach (RoBERTa) for the classification task, achieving an average area under the receiver operating characteristic (AUC) curve of 0.87 (SD 0.02; ie, 1 SD). The results demonstrate that open-source LLMs can enhance text classifiers’ performance for small datasets in health care contexts, providing promising pathways for improving medical education processes and patient care practices.

Conclusions
The study demonstrates the value of data augmentation with open-source LLMs, highlights the importance of privacy and ethical considerations when using LLMs, and suggests future directions for research in this field.
Factors Contributing to Successful Information System Implementation and Employee Well-Being in Health Care and Social Welfare Professionals: Comparative Cross-Sectional Study
Authors: Nadav Janna , Kaihlanen Anu-Marja , Kujala Sari , Keskimäki Ilmo , Viitanen Johanna , Salovaara Samuel , Saukkonen Petra , Vänskä Jukka , Vehko Tuulikki , Heponiemi Tarja 
Published: August 2024

Abstract

Background
The integration of information systems in health care and social welfare organizations has brought significant changes in patient and client care. This integration is expected to offer numerous benefits, but simultaneously the implementation of health information systems and client information systems can also introduce added stress due to the increased time and effort required by professionals.

Objective
This study aimed to examine whether professional groups and the factors that contribute to successful implementation (participation in information systems development and satisfaction with software providers’ development work) are associated with the well-being of health care and social welfare professionals.

Methods
Data were obtained from 3 national cross-sectional surveys (n=9240), which were carried out among Finnish health care and social welfare professionals (registered nurses, physicians, and social welfare professionals) in 2020‐2021. Self-rated stress and stress related to information systems were used as indicators of well-being. Analyses were conducted using linear and logistic regression analysis.

Results
Registered nurses were more likely to experience self-rated stress than physicians (odds ratio [OR] –0.47; P>.001) and social welfare professionals (OR –0.68; P<.001). They also had a higher likelihood of stress related to information systems than physicians (b=–.11; P<.001). Stress related to information systems was less prevalent among professionals who did not participate in information systems development work (b=–.14; P<.001). Higher satisfaction with software providers’ development work was associated with a lower likelihood of self-rated stress (OR –0.23; P<.001) and stress related to information systems (b=–.36 P<.001). When comparing the professional groups, we found that physicians who were satisfied with software providers’ development work had a significantly lower likelihood of stress related to information systems (b=–.12; P<.001) compared with registered nurses and social welfare professionals.

Conclusions
Organizations can enhance the well-being of professionals and improve the successful implementation of information systems by actively soliciting and incorporating professional feedback, dedicating time for information systems development, fostering collaboration with software providers, and addressing the unique needs of different professional groups.
Bridging the Telehealth Digital Divide With Collegiate Navigators: Mixed Methods Evaluation Study of a Service-Learning Health Disparities Course
Authors: Doueiri Zakaria Nadeem , Bajra Rika , Srinivasan Malathi , Schillinger Erika , Cuan Nancy 
Published: August 2024

Background
Limited digital literacy is a barrier for vulnerable patients accessing health care.

Objective
The Stanford Technology Access Resource Team (START), a service-learning course created to bridge the telehealth digital divide, trained undergraduate and graduate students to provide hands-on patient support to improve access to electronic medical records (EMRs) and video visits while learning about social determinants of health.

Methods
START students reached out to 1185 patients (n=711, 60% from primary care clinics of a large academic medical center and n=474, 40% from a federally qualified health center). Registries consisted of patients without an EMR account (at primary care clinics) or patients with a scheduled telehealth visit (at a federally qualified health center). Patient outcomes were evaluated by successful EMR enrollments and video visit setups. Student outcomes were assessed by reflections coded for thematic content.

Results
Over 6 academic quarters, 57 students reached out to 1185 registry patients. Of the 229 patients contacted, 141 desired technical support. START students successfully established EMR accounts and set up video visits for 78.7% (111/141) of patients. After program completion, we reached out to 13.5% (19/141) of patients to collect perspectives on program utility. The majority (18/19, 94.7%) reported that START students were helpful, and 73.7% (14/19) reported that they had successfully connected with their health care provider in a digital visit. Inability to establish access included a lack of Wi-Fi or device access, the absence of an interpreter, and a disability that precluded the use of video visits. Qualitative analysis of student reflections showed an impact on future career goals and improved awareness of health disparities of technology access.

Conclusions
Of the patients who desired telehealth access, START improved access for 78.7% (111/141) of patients. Students found that START broadened their understanding of health disparities and social determinants of health and influenced their future career goals.
Marilda Aparecida Behrens: educadora amorosa e exigente
Authors: Dallagassa Rossetin Ana Paula , Behrens Marilda Aparecida , Sezinando Santa'Ana Vaniza 
Published: August 2024

Esse trabalho visa investigar a trajetória de uma mulher que dedicou a sua vida à educação, nos últimos 45 anos da sua vida. Dedica-se especialmente para a formação de professores dentro de uma universidade particular de grande porte no município de Curitiba, Marilda Aparecida Behrens. O presente estudo utiliza como abordagem metodológica a pesquisa qualitativa, como recurso elegeu-se a história de vida, e, mais especificamente, na (auto)biografia que contempla a narrativa de investigação profissional. O objetivo deste estudo é discutir a relevância e empoderamento desta professora no cenário educacional, as escolhas de vida, buscando compreender experiências e vivências que contribuíram para sua atuação profissional no campo da Educação e mais especificamente na área de formação de professores. A temática está embasada na história de vida e fundamenta-se em autores como Gaulejac (1996), Santos (2003), Josso (2007) e Delory-Momberger (2015).
Sala de Aula Invertida em EAD: uma proposta de Blended Learning
Authors: Schneider Elton Ivan , Suhr Inge Renate Froze , Rolon Vanessa E. K. , Almeida Cláudia Mara de 
Published: August 2024

RESUMO O ensino a distância (EAD) está se tornando aos poucos e na opinião de outros rápido demais, em uma das principais modalidades de ensino no Brasil. Seu crescimento vertiginoso em tão curto espaço de tempo em comparação com o ensino tradicional abre espaços para novas possibilidades e modelos pedagógicos a serem utilizados na EAD. Este artigo trata da implantação do modelo pedagógico chamado FlippedClassroom ou sala de aula invertida, tradução nossa, em cursos superiores de tecnologia a distância, com o uso de encontros presenciais e a distância, mais conhecidos como metodologia Blended de EAD. A proposta foi desenvolvida e está implantada em 05 Cursos Superiores de Tecnologia e no de Curso de Pedagogia do Centro Universitário Internacional Uninter, submeter esta proposta ao crivo acadêmico é o objetivo deste artigo. Palavras-chave: Educação a Distância. Sala de Aula Invertida. Inovações metodológicas em educação. Blended Learning (aprendizagem mista). ABSTRACT The distance learning (ODL) is becoming little by little and, in the opinion of others, too fast, in one of the main methods of teaching in Brazil. Its rapid growth in such a short space of time in comparison with the traditional teaching opens spaces for new possibilities and pedagogical models to be used in ODL. This article deals with the implementation of the pedagogical model of the flipped classroom in ODL in higher education of Technology courses. Classes in these courses are both onsite and distance. This methodology is known as ODL Blended. The proposal has been developed and is being implemented in five Technology courses of higher education and in the Pedagogy course at Centro Universitário Internacional Uninter. Submitting the proposal to academic analysis is the objective of this article. Key words: Distance learning. Blended Learning.Flipped Classroom. RESUMEN Aprendizaje a Distancia (EAD) se está convirtiendo a los pocos y, en la opinión de los demás, demasiado rápido, en uno de las principales modalidades de enseñanza en Brasil. Su vertiginoso crecimiento en tan corto espacio de tiempo en comparación con la enseñanza tradicional, abre espacios para nuevas posibilidades y modelos pedagógicos que puedan ser utilizados en EAD. Este artículo se refiere a la aplicación del modelo pedagógico de la clase al revés en EAD, en cursos de educación superior en tecnología. Las reuniones, en estos cursos, son tanto en forma presencial como a distancia, esta metodología es conocida como aprendizaje mixto o Blended de EAD. La propuesta se desarrolló y se está aplicando en cinco cursos de enseñanza superior de Tecnología y en el curso de Pedagogía del Centro Universitario Internacional Uninter. Presentar la propuesta al juicio académico es el objetivo de este artículo. Palabras-clave: Educación a distancia. Aprendizaje mixto. (BlendedLearning). Aula innovadora. Clase al revés. (Flipped Classroom).
A educação feminina como forma de emancipação na história das mulheres
Authors: Gomes Calil de Siqueira 
Published: August 2024

RESUMO Este artigo realça a necessidade de emancipação das mulheres pela educação. Retrata-se a experiência delas em colégios religiosos, a partir da reconstrução da narrativa dos vencidos, dos excluídos, e que vai ganhando identidade na superação do contraditório processo de masculinização e ao mesmo tempo da dominação masculina, tornando-as visíveis aquelas em que ao longo da história ficaram envoltas em inúmeros e múltiplos discursos onde foram caracterizadas, como integrantes reclusas e peças sociais importantes. Palavras-Chave: Emancipação Feminina; História das Mulheres; Dominação Masculina. ABSTRACT This article highlights the need for empowerment of women through education. It portrays the experience of them in religious schools, from the narrative reconstruction of the vanquished, the excluded, and that identity is gaining in overcoming the adversarial process of masculinization while the male domination, making them visible to those in which throughout history were shrouded in numerous and multiple discourses which were characterized as reclusive members and important social parts. Keywords: Women's Emancipation; History of Women; Male domination. RESUMEN Este artículo hace hincapié en la necesidad de la emancipación de la mujer a través de la educación. Se describe la experiencia de ellas en colegios religiosos, desde la reconstrucción de la narrativa de los perdedores, de los excluidos, y que ganan identidad en la superación del proceso contradictorio de masculinización Y, al mismo tiempo, la dominación masculina, lo que los hace visibles a aquellas que, en el curso de la historia estaban envueltos en numerosos y varios discursos donde se caracterizaba, como integrantes reclusas y piezas sociales importantes. Palabras-Clave: Emancipación Femenina; Historia de las Mujeres; Dominación Masculina.