bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microincision Hydrophobic Acrylic Aspheric Toric Intraocular Lens for Astigmatism and Cataract Correction
Authors: Bissen-Miyajima Hiroko , Negishi Kazuno , Hieda Osamu , Kinoshita Shigeru 
Published: June 2015

PURPOSE:
To evaluate the efficacy and safety of a new acrylic one-piece toric intraocular lens (IOL).

METHODS:
This prospective multicenter clinical trial included 93 eyes of 61 patients that were implanted with a hydrophobic acrylic toric IOL from 2010 to 2012 and followed for 1 year. This IOL uses the platform of a microincision one-piece aspheric IOL, the NY-60 IOL (HOYA, Tokyo, Japan), with three increments in cylindrical power (NHT15, 1.5 diopters [D]; NHT23, 2.25 D; and NHT30, 3.0 D). The inclusion criterion was preoperative corneal astigmatism from 0.75 to 3.00 D. The primary endpoint was uncorrected distance visual acuity (UDVA) of 0.0 logMAR (20/20 Snellen) or better 6 months postoperatively. In addition to UDVA, corrected distance visual acuity (CDVA), residual astigmatism, stability of the IOL alignment, need of realignment, and the rate of Nd:YAG laser capsulotomy were evaluated up to 1 year postoperatively. Errors in astigmatic correction were assessed using Alpin’s vector analysis.

RESULTS:
The primary endpoint was achieved in 54.8% of eyes. One year postoperatively, the logMAR UDVAs were 0.02 ± 0.13, 0.05 ± 0.17, and 0.09 ± 0.14 with models NHT15, NHT23, and NHT30, which corresponds to 0.96 (19/20 Snellen), 0.89 (18/20 Snellen), and 0.82 (16/20 Snellen), respectively. One year postoperatively, the residual astigmatism was 0.66 ± 0.58 D. In each evaluation, the mean absolute change in the position of the axis mark was between 1.93° and 2.32°. Three eyes required repositioning of the IOL axis and 2 eyes received Nd:YAG laser capsulotomy. The correction error showed an undercorrection with against-the-rule astigmatism and overcorrection with with-the-rule astigmatism.

CONCLUSIONS:
The new one-piece toric IOL provided desirable clinical outcomes and stability in eyes with corneal astigmatism.

[
J Refract Surg.
2015;31(6):358–364.]
Simultaneous Correction of Unilateral Rainbow Glare and Residual Astigmatism by Undersurface Flap Photoablation After Femtosecond Laser-Assisted LASIK
Authors: Gatinel Damien , Saad Alain , Guilbert Emmanuel , Rouger Hélène 
Published: June 2015

PURPOSE:
To report and document a case of successful rainbow glare correction using undersurface ablation of the LASIK flap.

METHODS:
A 33-year-old woman was treated bilaterally for myopia using femtosecond laser-assisted LASIK with the FS200 femtosecond laser (Alcon Laboratories, Inc., Fort Worth, TX). Postoperatively, she complained of rainbow glare in her right eye, and presented some residual myopic astigmatism. Six months after the initial LASIK procedure, the right eye flap was lifted and a toric excimer correction was delivered on its stromal side.

RESULTS:
Visual symptoms related to the rainbow glare disappeared immediately after the completion of the procedure and did not reoccur. Uncorrected visual acuity improved by two lines.

CONCLUSIONS:
Rainbow glare following femtosecond laser-assisted LASIK can be successfully corrected by undersurface ablation of the flap.

[

J Refract Surg.
2015;31(6):406–410.]
Rapid-Manufacturing-Process for Elastomeric Components
Authors: Launhardt Martin , Drexler Maximilian , Drummer Dietmar 
Published: June 2015

The Selective Laser Sintering Process of
thermoplastics (SLS) enables the manufacturing of
components with complex shape in a short time period
without the manufacturing of a specific mold. However, this
manufacturing process is limited by the restricted range of
materials. In contrast to this primary shaping process,
vacuum casting allows a quick, inexpensive and highly
accurate process but it is limited to the reproduction of
already existing models. In a novel rapid tooling method,
these two processes are combined. Thus, silicone parts can
be manufactured using SLS molds. The manufacturing of
elastomeric parts in the vacuum casting process using SLS
molds is being investigated. Therefore, the adhesion of
silicone to the SLS mold, as well as the resulting mechanical
properties of the elastomeric parts are investigated. The combination of the SLS process and the vacuum casting process allows the rapid manufacturing of complex elastomeric parts with sufficient mechanical
properties. The surface roughness of the SLS mold influences the adhesion of the casting material to the mold, as well as the mechanical properties of the manufactured elastomeric components. The synergy of using selective laser sintered molds with the vacuum casting technique displays a
novel rapid manufacturing method.
Nouvelle Cuisine: Platelets Served with Inflammation
Authors: Kapur Rick , Zufferey Anne , Boilard Eric , Semple John W. 
Published: June 2015

Abstract
Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.
Intestinal Fucose as a Mediator of Host–Microbe Symbiosis
Authors: Pickard Joseph M. , Chervonsky Alexander V. 
Published: June 2015

Abstract
Fucose is an l-configuration sugar found abundantly in the mammalian gut. It has long been known to be induced there by the presence of bacteria, but only recently have some of the molecular mechanisms behind this process been uncovered. New work suggests that fucose can have a protective role in both gut-centered and systemic infection and inflammation. This review highlights recent studies showing that, in addition to acting as a food source for beneficial gut symbionts, host fucose can suppress the virulence of pathogens and pathobionts. The relevance of gut fucosylation to human diseases also is discussed.
Influência da acidez e do teor de fósforo do solo no crescimento inicial do mogno
Authors: Cardoso Arnon Afonso de Souza , Santos José Zilton Lopes , Tucci Carlos Alberto Franco , Farias Elias Paiva , Moura Rodolfo Pessoa de Melo 
Published: June 2015

<p class="Default"><span>A adubação fosfatada para espécies perenes nativas necessita de estudos, tanto em condições de campo, como na fase de mudas. No presente estudo, objetivou-se avaliar a interação entre calagem e níveis de fósforo no crescimento inicial e o acúmulo de nutrientes do mogno (<em>Swietenia macrophylla </em>King.), cultivado num Latossolo Amarelo Distrófico típico em casa de vegetação. O delineamento experimental utilizado foi o inteiramente casualizado em esquema fatorial, com três repetições. Os tratamentos foram constituídos de seis doses de P (11; 22; 44; 66; 88 e 110 mg dm</span><span class="A9"><sup><span>-3</span></sup></span><span>), além do tratamento controle (sem a aplicação de P), combinadas com a aplicação de 500 mg dm</span><span class="A9"><span>-3 </span></span><span>de calcário ou sem a adição do corretivo. A adição de doses crescentes de P com aplicação de calcário favoreceram o crescimento inicial e o acúmulo de nutrientes em mudas de mogno, todavia, sem apresentar interações entre si. A máxima eficiência econômica para a produção de matéria seca foi alcançada com a aplicação de 41,6 mg dm</span><span class="A9"><sup><span>-3</span></sup></span><span>de P, associada com adição 500 mg dm</span><span class="A9"><sup><span>-3 </span></sup></span><span>de calcário dolomítico.</span></p><p class="Default"> </p>
Los mapas conceptuales interactivos como recursos didácticos en el ámbito universitario
Authors: Cabero Almenara Julio , Ballesteros Regaña Cristóbal , López Meneses Eloy 
Published: June 2015

En esta investigación describimos las experiencias desarrolladas en dos universidades andaluzas (Universidad de Sevilla y Pablo de Olavide) con la finalidad de experimentar y conocer las posibilidades de los mapas conceptuales interactivos como recursos didácticos implementados a través de edublog. Entre las aportaciones más relevantes hay que destacar cómo su diseño y difusión (con la ayuda de las aplicaciones de software social: Mindomo y Blogger) facilitó la participación activa de los estudiantes en la construcción de su propio y nuevo conocimiento mediante la selección, estructuración e interpretación de las principales características de los dos ámbitos conceptuales trabajados en cada universidad: las posibilidades y limitaciones de las TIC y los ámbitos de intervención del educador y trabajador social.
Variability of Different Reference Bodies in Normal, Keratoconus, and Collagen Crosslinked Corneas
Authors: Labiris Georgios , Giarmoukakis Athanassios , Rampotas Alexandros , Symeou Maria , Bougatsou Panagiota , Sideroudi Haris , Kozobolis Vassilios P. 
Published: June 2015

Purpose To evaluate the reproducibility of different Scheimpflug imaging–derived reference bodies in normal, keratoconus (KC), and crosslinked (CXL) eyes. Methods In this prospective, observational study, 40 participants populated the control group (CG), while 33 and 34 patients formed the KC group and the CXL group, respectively. One eye was randomly selected when both were eligible. Elevation measurements were obtained using Scheimpflug camera, by applying the following reference bodies: the best fit sphere (BFS), the best fit toric ellipsoid (BFTE), the best fit toric ellipsoid with fixed eccentricity of 0.4 (BFTEF), the best fit ellipsoid (BFE), and the best fit torus, by 2 operators in 2 sessions. The variability of different reference bodies’ parameters was assessed using intraclass correlation coefficient (ICC). Results Differences between operators were nonsignificant for all reference bodies’ parameters in all study groups (p>0.1). Regarding CG, BFS for both operators and BFTE for operator 1 presented the best intrasession repeatability (majority of ICCs >0.90), while average interobserver reliability was recorded for the majority of reference bodies’ parameters. Regarding KC and CXL groups, BFS, BFTEF, and BFE reference bodies demonstrated the best intrasession and interobserver reproducibility (majority of ICCs >0.90) for both groups. Steep and flat radius parameters presented the best overall reproducibility, with the majority of ICCs for all reference bodies ranging above 0.90, in all study groups. Conclusions High variability was encountered for most reference surfaces. Ellipsotoric surfaces presented acceptable repeatability in KC and post-CXL corneas.
Intravitreal Autologous Plasmin Prepared by Urokinase for Vitreolysis: A Pilot Study
Authors: Maleki Alireza , Tohidi-Zand Seyed-Reza , Amirizadeh Naser , Dehghan-Haghighi Javid , Zanjani Habibollah , Arish Mohammad , Salari Amir-Masoud , Mirhosseini Seyed Mohammad , Abrishami Mojtaba 
Published: June 2015

Purpose To evaluate the effects of intravitreal autologous plasmin injection (IVAP) on vitreoretinal diseases and vitreolysis. Methods In this interventional, prospective, case series pilot study, 8 eyes were assigned to IVAP. Plasminogen as centrifuged from the patients’ plasma was converted to plasmin by adding urokinase. A total of 0.2 mL extracted plasmin was injected intravitreally. Posterior vitreous detachment (PVD) and potential injection-related complications at week 4 were the primary outcome measures. Secondary outcomes included changes in best-corrected visual acuity (VA) (logMAR) and central macular thickness (CMT). Results Mean age of the patients was 54.35 years. Two patients had complete PVD and 3 patients had partial PVD. Four patients had decrease in CMT. The VA was not changed in 6 patients, improved in 1 patient, and decreased in 1 patient. No uveitis, endophthalmitis, or postinjection vitreous hemorrhage was observed. Conclusions This pilot study demonstrated the efficacy of urokinase-prepared IVAP injection on releasing vitreomacular traction and inducing vitreolysis.
Ranibizumab Prefilled Syringes: Benefits of Reduced Syringe Preparation Times and Less Complex Preparation Procedures
Authors: Souied Eric , Nghiem-Buffet Sylvia , Leteneux Claudia , Bayer Sascha , Derveloy Audrey , Sagkriotis Alexandros , Becker Guido , Cohen Salomon-Yves 
Published: June 2015

Purpose A recently developed ranibizumab prefilled syringe (PFS) eliminates several preparatory steps versus the standard vial-based method, and is expected to reduce syringe preparation time (SPT) and enhance procedural simplicity for intravitreal injections. Methods Syringe preparation times for the ranibizumab PFS and vial were recorded during standard treatment sessions at 2 centers, without randomization. The duration of each step in preparing the syringe was recorded. At each center, total SPT (mean total duration of all syringe preparation steps) for each method was compared using a 2-tailed t test. Results In total, 97 SPTs were analyzed across both centers. Center 1 SPTs were 46 seconds (PFS) versus 75 seconds (vial; difference, 29 seconds; p<0.001). Center 2 SPTs were 46 seconds (PFS) versus 63 seconds (vial; difference, 17 seconds; p<0.001). This equates to a 27%-39% reduction in SPT when using the PFS rather than the vial, resulting mostly from the reduced number of syringe preparation steps associated with the PFS. Conclusions Syringe preparation times for ranibizumab intravitreal injections are significantly shorter with the PFS than with the vial. The time saved by using the PFS may benefit physicians and nurses, and the simplicity of the injection preparation process with the PFS is advantageous.
Foveal Pit Morphology Evaluation during Optical Biometry Measurements using a Full-Eye-Length Swept-Source OCT Scan Biometer Prototype
Authors: Bertelmann Thomas , Blum Marcus , Kunert Kathleen , Haigis Wolfgang , Messerschmidt-Roth Anke , Peter Monika , Buehren Tobias , Sekundo Walter 
Published: June 2015

Purpose To assess the scan quality of foveal pit morphology (FPM) and to quantify central retinal thickness (CRT) during routine optical biometry measurements with a full-eye-length swept-source optical coherence tomography (SS-OCT) scan biometer prototype (IOLMaster700) and to compare these results with standard examinations using spectral-domain optical coherence tomography (SD-OCT) technique (Cirrus4000 SD-OCT). Methods As part of a SS-OCT scan protocol to measure biometric parameters for intraocular lens power calculation, central horizontal 1 mm retinal B scans were taken from phakic (group I) and pseudophakic (group II) nonvitrectomized eyes. To evaluate FPM, macular scans of either examination technique were subjectively analyzed and compared. Repeated CRT measurements were performed to analyze repeatability and consistency of IOLMaster700 recordings. These results were compared with CRT evaluations using SD-OCT. Results Overall, 146 eyes of 146 patients were included in this series. The subjective assessments of FPM are illustrated. Repeated CRT measurements (repeatability) with the IOLMaster700 disclosed an overall intraclass correlation of 0.57 (group I: 0.48; group II: 0.89). Overall coefficient of variation (accuracy) was calculated to be 12.43% (group I: 14.21%; group II: 5.66%). The comparison of CRT measurements between both devices showed significant differences in group I (p = 0.006). Conclusions Compared with SD-OCT, resolution of the 1 mm retinal B scan of SS-OCT scan biometry was lower. However, advanced pathologic characteristics were clearly discernible. Repeatability and accuracy of CRT measurements were acceptable though lower than with the standard SD-OCT technique. The CRT differed significantly in eyes of particular interest (group I) between both devices. The new scan could provide useful information for subsequent patient examination and further treatment planning for cataract surgery.
The Seasonality of Slipped Upper Femoral Epiphysis - Meta-Analysis: A Possible Association with Vitamin D
Authors: Farrier Adam J. , Ihediwa Ugwunna , Khan Shoaib , Kumar Ameet , Gulati Vivek , Uzoigwe Chika E. , Choudhury Muhammed Z. 
Published: June 2015

We performed a meta-analysis of studies evaluating the seasonality of slipped upper femoral epiphysis (SUFE). In addition we compared the monthly incidences of SUFE at latitudes greater than 40° with the established serum 25-hydroxyvitamin levels for children resident at a comparative latitude. In total 11 relevant studies were identified, involving 7451 cases of SUFE. There was significant variation in the month of onset of SUFE. The degree of variability increased with increasing latitude. The modal month of symptomatic onset was dependent upon latitude. At latitudes greater than 40°, the most common month of onset was August. At latitudes between 20° and 40°, this was earlier in the calendar year, around April. The seasonal variability was statistically significant (p<0.0001 and p<0.005 for latitudes >40° and 20°-40° respectively). The pattern of monthly fluctuation in onset of SUFE very closely mirrored the monthly pattern of variation for serum 25-hydroxyvitamin D3. There was a very strong positive correlation (Spearman rank rho = + 0.8, p = 0.001). There is a monthly variation in incidence of SUFE. The degree of variability increases with increasing latitude. There may be an association with vitamin D. We hypothesise that elevated serum 25-hydroxyvitamin D3 accelerates growth thus rendering the growth plate vulnerable to slippage in analogous manner to the pubertal growth spurt.
Preoperative Predictors of Outcome in the Arthroscopic Treatment of Femoroacetabular Impingement
Authors: Nabavi Arash , Olwill Caroline M. , Harris Ian A. 
Published: June 2015

Aims The aim of this study was to establish preoperative factors associated with a good outcome in the surgical treatment of femoroacetabular impingement. Methods A prospective study including 253 consecutive patients (280 hips) was carried out. We defined a “good” score as one which had either a 20 point improvement from preoperative to 12 months postoperative follow-up, or a score of over 80 points at 12-month follow-up in either the Non Arthritic Hip Score (NAHS) or Modified Harris Hip Score (MHHS). We analysed 9 potential predictors of 12-month postoperative outcome: patient age, gender, BMI, surgery type (primary/revision), preoperative anxiety level, preoperative labro-chondral damage, operative side, patients belonging to the armed forces and patients being treated under the workers compensation scheme. We used logistic regression (multivariable, adjusted) and, Fisher's exact test and student t test (bivariate, unadjusted) to analyse the data. Results A strong association between workers’ compensation status and not achieving a good outcome following arthroscopic surgery for femoroacetabular impingement (odds ratio 3.84, 95% CI, 0.13-0.51, P<0.0001) was found. A negative effect on postoperative outcome was also observed with increased BMI, although this association was modest (odds ratio 1.06, 95% CI, 0.87-0.99 p = 0.03). Patients with a higher preoperative score did better at 12 months than the rest of the cohort. Conclusions The data from this study may be useful for both patient and physician to consider when deciding on a suitable treatment in potential surgical candidates suffering from femoroacetabular impingement.
Pelvic Discontinuity: Modern Techniques and Outcomes for Treating Pelvic Disassociation
Authors: Schwarzkopf Ran , Ihn Hansel E. , Ries Michael D. 
Published: June 2015

Pelvic discontinuity is an uncommon condition that usually presents in the revision total hip arthroplasty population. However, its incidence will most likely increase due to the increasing number of primary and revision total hip arthroplasties (THA) done in recent years. Pelvic discontinuity (acetabular disassociation) is perhaps one of the more challenging cases for the hip arthroplasty surgeon to manage. Historically, the management of pelvic discontinuity has been wrought with many challenges. What follows is a review of the current techniques and outcomes for acetabular reconstruction in patients with acetabular disassociation including: porous metal components, internal fixation with acetabular reconstruction, acetabular distraction with jumbo cups, cup and cage construct, and the use of custom triflange. The complexity of pelvic discontinuity and with the myriad of options available to the hip arthroplasty surgeon to address this particular issue, pre-operative planning becomes all the more essential.
Extracorporeal Membrane Oxygenation and Severe Portopulmonary Hypertension following Liver Transplantation: Brief Report
Authors: Chan-Dominy Amy C. , Rahiman Sarfaraz N. , Anders Marc , Butt Warwick 
Published: June 2015

Background Patients with severe portopulmonary hypertension (PoPH) responsive to medical therapy may be considered for liver transplantation. We present a case of extracorporeal membrane oxygenation (ECMO) resuscitation for PoPH crisis in a child following liver transplantation (LT), and review the literature on management of this challenging setting. Case report A 7-year-old girl, with previous Kasai portoenterostomy and subsequent severe PoPH responsive to pulmonary vasodilator therapy, underwent orthotopic LT. Five days following surgery, she had an asystolic arrest with suprasystemic pulmonary hypertension, and was resuscitated with ECMO therapy. Multi-modal strategies included sildenafil, ambrisentan, nitric oxide, intravenous Epoprostenol infusion, levosimendan, and atrial septostomy. Ten days after her LT, exploration for bleeding was necessary following abdominal drain removal. By 10 days of ECMO support, she was reviewed and considered for lung transplantation. Unfortunately, she deteriorated precipitously with abdominal compartment syndrome and multi-organ failure; sadly, life support was withdrawn 23 days after transplantation. Discussion Patients with severe PoPH may need combined thoracic organ and liver transplantation either at single or serial events. Case reports on ECMO use include resuscitation after massive pulmonary embolism during liver transplantation, bridge until the goal of vasodilatory therapy was reached in worsening PoPH following LT, and bridge to lung or repeat liver transplantation for severe pulmonary hypertension. Conclusions ECMO resuscitation and support may be deployed as rescue therapy around the period of liver transplantation. We highlight the importance of patient selection and high risk of complications during ECMO therapy as a bridge to PoPH control.