bluuebunny/crossref_metadata_2025_split huggingface dataset:
MATCHING THE OTHER SIDE: RADIOLOGICAL VARIABILITY IN STAGED, BILATERAL TOTAL HIP ARTHROPLASTY
Authors: Schaffler B. C. , Robin J. X. , Katzman J. L. , Manjunath A. , Davidovitch R. , Rozell J. C. , Schwarzkopf R. 
Published: August 2024

The purpose of this study was to assess the variability in implant position between sides in patients who underwent staged, bilateral THA and whether variation from one side to the other affected patient-reported outcomes.A retrospective review was conducted on 207 patients who underwent staged, bilateral THA by the same surgeon from 2017–2022. Leg length, acetabular height, cup version, and coronal and sagittal stem angles were assessed radiographically and compared to the contralateral THA. Surgical approach and technology utilization were further assessed for their impact on variability. Linear regression was used to model the relationship between side-to-side variability and patient-reported outcome measures (PROMS).Between sides, mean radiographic leg length varied by 4.6mm (0.0–21.2), acetabular height varied by 3.3mm (0.0–13.7), anteversion varied by 8.2° (0.0 to 28.7), coronal stem alignment varied by 1.1° (0.0 to 6.9), and sagittal angulation varied by 2.3° (0.0 to 10.5). The anterior approach resulted in more variability in stem angle position in both the coronal (1.3° vs. 1.0°, p=0.036) and sagittal planes (2.8° vs. 2.0° p=0.012) compared to the posterior approach. The posterior approach generally led to more anteversion than the anterior approach. Use of robotics or navigation for acetabular positioning did not increase side-to-side variability in cup-related position or leg length. Despite considerable side-to-side variability, Hip dysfunction and osteoarthritis outcome scores (HOOS JR) were not affected by higher levels of position inconsistency.Staged, bilateral THA results in considerable variability in component position between sides. The anterior approach leads to more side-to-side variability in sagittal stem angle and cup anteversion than the posterior approach. Navigation and robotics do not improve the consistency of component position in bilateral THA. Variation in implant position was not associated with differences in PROMs, suggesting that despite variability, patients can tolerate these differences between sides.
OBESITY AND TOTAL HIP ARTHROPLASTY SURGERY
Authors: de Steiger R. , Wall C. , Truong A. , Lorimer M. , Stoney J. , Graves S. 
Published: August 2024

Obesity is a known risk factor for developing osteoarthritis and is also associated with an increased risk of developing complications post total hip replacement (THR). This study investigated the association between obesity and the risk of undergoing THR in Australia.From July 2017 to June 2018 a National Health Survey was conducted by the Australian Bureau of Statistics to collect height and weight data on a representative sample of patients across urban and rural areas across the country. This study examined a cohort of patients undergoing primary THR utilising data from the Australian Orthopaedic Association National Joint Replacement Registry from the same time period. Obesity classes were determined according to WHO criteria.Body mass index (BMI) for patients undergoing THR were obtained and the distribution of THR patients by BMI category was compared to the general population, in age and sex sub-groups.Generalised linear models assuming a binomial distribution and a log link were used to generate relative risks. Data from underweight categories, and age categories 34 years and younger, were excluded from further analyses because of small numbers.Data from the health survey showed there were 35.6% of persons overweight and 31.3% obese. During the same period, 32,495 primary THR were performed for osteoarthritis in Australia on patients who had a BMI recorded. Of these patients 37.1% were overweight and 41.7% were obese. Compared to the general population, there was a higher incidence of Class I, II, and III obesity in patients undergoing THR in both sexes aged 35 to 74 years. Class III obese females and males aged 55–64 years were 2.9 and 1.7 times more likely to undergo HR, respectively (p<0.001). Class III obese females and males underwent THR on average 5.7 and 7.0 years younger than their normal weight counterparts, respectively.Obese Australians are at increased risk of undergoing THR, and at a younger age. A national approach to address the prevalence of obesity, and possible prevention strategies, is needed.
Schistosomicidal effects of histone acetyltransferase inhibitors against Schistosoma japonicum juveniles and adult worms in vitro
Authors: Xu Jing , Wang Jing-Yi , Huang Ping , Liu Zi-Hao , Wang Yu-Xin , Zhang Run-Ze , Ma Hui-Min , Zhou Bi-Yue , Ni Xiao-Yan , Xiong Chun-Rong , Xia Chao-Ming 
Published: August 2024

Background
Schistosomiasis is a relatively neglected parasitic disease that afflicts more than 250 million people worldwide, for which the control strategy relies mainly on mass treatment with the only available drug, praziquantel (PZQ). This approach is not sustainable and is a priority for developing novel drug candidates for the treatment and control of schistosomiasis.

Methodologys/Principal findings
In our previous study, we found that DW-3-15, a kind of PZQ derivative, could significantly downregulate the expression of the histone acetyltransferase of Schistosoma japonicum (SjHAT). In this study, several commercially available HAT inhibitors, A485, C646 and curcumin were screened in vitro to verify their antischistosomal activities against S. japonicum juveniles and adults. Parasitological studies and scanning electron microscopy were used to study the primary action characteristics of HAT inhibitors in vitro. Quantitative real-time PCR was employed to detect the mRNA level of SjHAT after treatment with different HAT inhibitors. Our results demonstrated that curcumin was the most effective inhibitor against both juveniles and adults of S. japonicum, and its schistosomicidal effects were time- and dose dependent. However, A485 and C646 had limited antischistosomal activity. Scanning electron microscopy demonstrated that in comparison with DW-3-15, curcumin caused similar tegumental changes in male adult worms. Furthermore, both curcumin and DW-3-15 significantly decreased the SjHAT mRNA level, and curcumin dose-dependently reduced the SjHAT expression level in female, male and juvenile worms.

Conclusions
Among the three commercially available HATs, curcumin was the most potent against schistosomes. Both curcumin and our patent compound DW-3-15 markedly downregulated the expression of SjHAT, indicating that SjHAT may be a potential therapeutic target for developing novel antischistosomal drug candidates.
Early Occupational Therapy Intervention post-stroke (EOTIPS): A randomized controlled trial
Authors: García-Pérez Patricia , Rodríguez-Martínez María Carmen , Gallardo-Tur Alejandro , Blanco-Reina Encarnación , de la Cruz-Cosme Carlos , Lara José Pablo 
Published: August 2024

Background
Occupational therapy (OT) is an effective evidence-based intervention that positively influences stroke patients’independence recovery, leading to new opportunities for better quality of life outcomes.

Objectives
To explore the effectiveness of an early OT intervention program (EOTIPS) in the process of hospital to home discharge after stroke in Spain.

Material and methods
We conducted a prospective, randomized controlled clinical trial that included 60 adults who suffered a stroke and were discharged home. Participants assigned to the experimental group (n = 30) were included in EOTIPS and compared with a control group (n = 30). Evaluations assessed quality of life (Stroke and Aphasia Quality of Life Scale [SAQOL-39]), functional independence (Modified Rankin Scale [mRS], Barthel Index [BI] and Stroke Impact Scale-16 [SIS-16]), perceptual-cognitive skills (Montreal Cognitive Assessment [MoCA]), upper limb function (Fugl Meyer Assessment [FMA]), mobility (Berg Balance Scale [BBS] and Timed Up & Go [TUG]), communication skills (Communicative Activity Log [CAL]) and mood disorders (Beck Depression Inventory–II [BDI-II] and Hamilton Anxiety Scale [HAM-A]); they were completed within two weeks post-stroke and after three months follow-up. Statistical analysis included intent-to-treat analysis, considering all participants (dropouts as failures), and efficacy analysis, considering only end-of-treatment participants.

Results
Participants in the intervention group showed a significant better evolution in the main outcome measure of quality of life (SAQOL-39 p = .029), as well as for independence (mRSp = .004), perceptual-cognitive skills (MoCA p = .012)and symptoms of depression (BDI-II p = .011) compared to the control group.

Conclusions
EOTIPS was effective in improving quality of life, as well as enhancing perceptual-cognitive skills, independence and reducing levels of depression for patients who suffered a stroke in a Spanish cohort and could be considered as an applicable non-pharmacologic therapeutic tool that can lead to patients’ positive outcomes after stroke.
This study was registered on ClinicalTrials.gov with the identifier NCT04835363.
Reproducibility of autonomic cardiovascular function and hemodynamics at rest and during recovery from exercise
Authors: Ylinen Venla P. , Valtonen Rasmus I. P. , Junttila M. Juhani , Kerkelä Risto , Huikuri Heikki V. , Tulppo Mikko P. 
Published: August 2024

AbstractSmartwatches and home‐based blood pressure (BP) devices have permitted easy use of heart rate variability (HRV) and BP to identify the recovery status of users after acute exercise training. The reproducibility of HRV and BP after exercise in healthy young participants is not well known. Eighteen participants (age 27 ± 6 years, female n = 8) performed test and retest aerobic exercises (cycling, 30 min, 60% of peak workload, W) and a control session in randomized order. RMSSD, high and low‐frequency power of RR intervals, and BP were measured at rest and 30–60 min after interventions. The relative reproducibility was assessed by the intraclass correlation coefficient (ICC) and 95% confidence interval (95% CI). The absolute reproducibility was evaluated using the coefficient of variation (CV%). HRV indices revealed moderate‐to‐excellent reproducibility at rest (ICC 0.81–0.86; 95% CI 0.53–0.95) but not after exercise (ICC −0.06 to 0.60; 95% CI −1.85 to 0.85). Systolic BP had a good‐to‐excellent reproducibility before (ICC 0.93; 95% CI 0.81–0.98, CV% 4.2) and after exercise (ICC 0.93; 95% CI 0.81–0.97, CV% 4.2). The reproducibility of HRV indices is poor after exercise in young participants. However, the reproducibility of BP is excellent at rest and after aerobic exercise.
Comparative analysis of BCR::ABL1 p210 mRNA transcript quantification and ratio to ABL1 control gene converted to the International Scale by chip digital PCR and droplet digital PCR for monitoring patients with chronic myeloid leukemia
Authors: Saisaard Wannachai , Owattanapanich Weerapat 
Published: August 2024

Abstract

Objectives
Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome, leading to the BCR::ABL1 fusion gene and hyper-proliferation of granulocytes. Tyrosine kinase inhibitors (TKIs) are effective, and minimal residual disease (MRD) monitoring is crucial. Digital PCR platforms offer increased precision compared to quantitative PCR but lack comparative studies.

Methods
Eighty CML patient samples were analyzed in parallel using digital droplet PCR (ddPCR) (QXDx™ BCR-ABL %IS Kit) and chip digital PCR (cdPCR) (Dr. PCR™ BCR-ABL1 Major IS Detection Kit).

Results
Overall, qualitative and quantitative agreement was good. Sensitivity analysis showed positive percentage agreement and negative percentage agreement were both ≥90 %, and the quadratic weighted kappa index for molecular response (MR) level categorization was 0.94 (95 %CI 0.89, 0.98). MR levels subgroup analysis showed perfect categorical agreement on MR level at MR3 or above, while 35.4 % (17/48) of patient samples with MR4 or below showed discordant categorizations. Overall, Lin’s concordance correlation coefficient (CCC) for the ratio of %BCR::ABL1/ABL1 converted to the International Scale (BCR::ABL1
IS) was almost perfect quantitative agreement (Lin’s CCC=0.99). By subgroups of MR levels, Lin’s CCC showed a quantitative agreement of BCR::ABL1
IS decreased as MR deepened.

Conclusions
Both cdPCR and ddPCR demonstrated comparable performance in detecting BCR::ABL1 transcripts with high concordance in MR3 level or above. Choosing between platforms may depend on cost, workflow, and sensitivity requirements.
Yield stability of biofertilizer treatments to soybean in the rainy season based on the GGE biplot
Authors: Wijaya Acep Atma , Sukmasari Miftah Dieni , Nugraha Dadan Ramdani , Gandaseca Seca 
Published: August 2024

Abstract
Soybeans (Glycine max L.) play an essential role in meeting the nutritional needs of Indonesians. However, national soybean production cannot meet domestic needs. Increasing the planting frequency during the rainy season is an effort to increase the national soybean production. Planting soybeans in the rainy season will reduce the yield and growth of soybeans, so cultivation technology is needed to increase soybean yields in the rainy season, one of which is the use of biofertilizers and cultivars. This study aimed to analyze a suitable combination of cultivation and biofertilizer doses to increase soybean production during the rainy season. Selection of the right cultivar combination and biofertilizer dosage will increase yields. The research was conducted from 2021 to 2023 during the rainy season in Majalengka Regency, West Java Province, Indonesia. The cultivation technology that provides stable soybean yields was analyzed using a GGE biplot. The results of this research show that the appearance of soybean yields varies every year, and there is an interaction between the application of cultivation technology and the year of planting. Cultivation technologies that show a stable appearance are Anjasmoro variety + 20 kg h−1 dose biofertilizer, Dega 1 variety + 0 kg h−1 dose biofertilizer and Dega 1 variety + 10 kg h−1 dose of biofertilizer. These results can be used as a reference for farmers planting soybeans during the rainy season.
Interfacial bonding characteristics of multi-walled carbon nanotube/ultralight foamed concrete
Authors: Zhang Jing , Zhang Xiaolei 
Published: August 2024

Abstract
In the development of carbon nanotube (CNT)-reinforced cement-based matrices, one of the fundamental issues that investigators are confronting is CNT/cement-based matrix interfacial bonding, which determines the load transfer capability from the matrix to the CNT. In the present work, the stress transfer properties of multi-walled carbon nanotubes (MWCNTs) and ultralight foamed concrete matrices were studied using microscopic Raman spectrometry analysis. Two types of CNTs, such as MWCNT and MWCNT-COOH, were considered, wherein MWCNT-COOH was covered with fundamental COOH groups. The results show that the compressive and flexural strengths were 75 and 236% better for ultralight foamed concrete with a dry density of 200 kg/m3 with 0.4 wt% MWCNT-COOH addition, respectively. This indicates that the fundamental COOH groups of the MWCNT play an important role in determining the interfacial bonding characteristics between the MWCNT and the ultralight foamed concrete matrix. Therefore, the attachment of COOH groups with a reasonable concentration to the MWCNT surface may be an effective way to significantly improve the load transfer between the MWCNT and the ultralight foamed concrete matrix, leading to increased compressive and flexural strength values of composites.
Influence of a Shaky Start upon Overdamped or Underdamped Field Permeability (Slug) Test Results
Authors: Chapuis Robert P. 
Published: August 2024

Abstract
ASTM D4044/D4044M-15A, Standard Test Method (Field Procedure) for Instantaneous Change in Head (Slug) Tests for Determining Hydraulic Properties of Aquifers (Withdrawn), describes several methods to start a slug test, which all involve some quick slugging of the water column in the riser pipe. Having a standard for the slugging action seems important. However, the initial dynamic effects are mostly ignored in slug test theories. In the field, slug tests may have a shaky start instead of a rapid and clean start. The question is, does the slugging quality influence the test results? This can be studied using recent tests for which shaky starts were registered by a pressure transducer (PT) and an atmospheric pressure transducer (APT). The PT–APT pair must be calibrated and synchronized, as explained in previous articles, but this is rarely done and regrettably it is not requested in standards. This article uses the data collected by PT–APT pairs for a few shaky starts in aquifers. Theoretical and practical aspects are explained. Then, this article examines the graphs that are needed for a correct analysis and compares results obtained with either a clean start or a shaky start in the same monitoring well. The test data are fitted with a three-parameter model for overdamped (OD) tests and a four-parameter model for underdamped (UD) tests. For OD tests, the start quality slightly influences the results for hydraulic conductivity, K, and piezometric level, PL, for the test. For UD tests, the slugging action may influence markedly the K value derived with the ASTM D5785/D5785M-20, Standard Practice for (Analytical Procedure) for Determining Transmissivity of Confined Nonleaky Aquifers by Underdamped Well Response to Instantaneous Change in Head (Slug Test), method. The analysis of residuals between data and best fit is very useful in selecting the correct starting time and avoiding the influence of slug dynamic effects and outgassing effects. Several recommendations are made to improve standards.
The book science literature in the personal library of Vaclovas Biržiška
Authors: Lietuvninkaitė Nijolė 
Published: August 2024

The subject fields of the science collection of Vaclovas Biržiška, and its importance for the scientific, pedagogical, and practical activities of this famous bibliographer, have been investigated.
Vaclovas Biržiška compiled a collection of books of about 5,000 copies. In 1944, this collection was moved to Kaunas University Library. After the reorganization of Kaunas University in 1950, the collection was distributed to several institutions. At present, approximately 2,000 copies of this collection are in the Library of Kaunas University of Technology, and about 1,000 copies are in the Vilnius University Library. We may find books from this collection in other major Lithuanian libraries as well. Vaclovas Biržiška collected approximately 300 key theoretical and historical works on book science published in Poland, Russia, Germany, and other countries from the 19th century to the first part of the 20th century. The collection was composed of books and periodicals on book history, bibliography, and librarianship. Vaclovas Biržiška had a significant collection on book history, including works on incunabula, book art, the collection of rare and valuable books, and other literature. He also collected bibliography science and history, including works on Russian, Polish, and German national bibliography.
The renowned German scientist G. Schneider, with his bibliography theory, exerted a significant influence on Vaclovas Biržiška's work and Lithuanian bibliography in general. Biržiška gathered many different bibliographical lists (indexes).
The acquisition of works on book science is connected to Vaclovas Biržiška's role as the director of Kaunas University Library. He ensured the applicability of experiences from foreign countries.
The acquisition of his personal library was related to his professional needs. He used this collection for studies, investigations, and in articles for the Lietuviškoji enciklopedija. The most important bibliographers' works were reviewed by Vaclovas Biržiška in journals such as Knygos, Baras, and Bibliografijos žinios. The book science literature was useful when he started teaching book history and bibliography at Kaunas University.
Vaclovas Biržiška adapted the experience of foreign libraries to his library activities. The book science collection was a very important supplement to the scientific and practical activities of Vaclovas Biržiška.
غوغل كلاس رووم وتأثير استخدامه في تعليم مهارة القراءة
Authors: Iswara Dana , Wahab Muhbib Abdul , Albantani Azkia Muharom , Hudatullah Ruwaida , Farihin Farihin 
Published: August 2024

The objectives of this research are to detect the impact of the use of Google Classroom on the results of learning students’ substantive reading skills at this school, and to analyse the supporting and inhibiting factors in its use. After the researcher's pretest and postest of the students, received the pretest with the largest results 65 and the smallest results 40 and the average 50. And posttest got the biggest results 80 and the smallest results 55 and average 68 and got N-gain 0,6 at the good grade level. The researcher analyzed the data by law (T-test) with the help of SPSS 21 obtained Sig value. (2-tailed) 0,000 below 0,05 the alternative hypothesis H_a accepted the original hypothesis H_0 rejected. The conclusion of this research is that the teaching process using Google Classroom for students in this school has a statistically significant effect on the results of learning the reading skill.
Disparities in Guideline Adherence for Febrile Infants in a National Quality Improvement Project
Authors: McDaniel Corrie E. , Truschel Larissa L. , Kerns Ellen , Polanco Yenimar Ventura , Liang Danni , Gutman Colleen K. , Cunningham Shani , Rooholamini Sahar N. , Thull-Freedman Jennifer , Jennings Brittany , Magee Sloane , Aronson Paul L. ,   AAP REVISE II QI COLLABORATIVE
Published: August 2024

BACKGROUND
Interventions aimed to standardize care may impact racial and ethnic disparities. We evaluated the association of race and ethnicity with adherence to recommendations from the American Academy of Pediatrics’ clinical practice guideline for febrile infants after a quality improvement (QI) intervention.

METHODS
We conducted a cross-sectional study of infants aged 8 to 60 days enrolled in a QI collaborative of 99 hospitals. Data were collected across 2 periods: baseline (November 2020–October 2021) and intervention (November 2021–October 2022). We assessed guideline-concordance through adherence to project measures by infant race and ethnicity using proportion differences compared with the overall proportion.

RESULTS
Our study included 16 961 infants. At baseline, there were no differences in primary measures. During the intervention period, a higher proportion of non-Hispanic white infants had appropriate inflammatory markers obtained (2% difference in proportions [95% confidence interval (CI) 0.7 to 3.3]) and documentation of follow-up from the emergency department (2.5%, 95% CI 0.3 to 4.8). A lower proportion of non-Hispanic Black infants (−12.5%, 95% CI −23.1 to −1.9) and Hispanic/Latino infants (−6.9%, 95% CI −13.8 to −0.03) had documented shared decision-making for obtaining cerebrospinal fluid. A lower proportion of Hispanic/Latino infants had appropriate inflammatory markers obtained (−2.3%, 95% CI −4.0 to −0.6) and appropriate follow-up from the emergency department (−3.6%, 95% CI −6.4 to −0.8).

CONCLUSIONS
After an intervention designed to standardize care, disparities in quality metrics emerged. Future guideline implementation should integrate best practices for equity-focused QI to ensure equitable delivery of evidence-based care.