bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic analysis of heat shock activator complex in the peripheral blood of Parkinson's disease patients and its clinical significance
Authors: İnalkac Gemici Yagmur , Tasci Irem , Dundar Muhammed , Ozgen Nazmi , Danis Nefsun , Gozde Gozukara Harika , Koc Ahmet 
Published: June 2024

Objectives: This study aimed to investigate the methylation changes of related genes in the peripheral blood and their clinical significance in Parkinson's disease (PD) and whether the methylation change of the gene encoding long noncoding RNA was different in the blood of patients and controls.
Patients and methods: This prospective cross-sectional, controlled study was conducted with 45 participants (22 males, 23 females; mean age: 60.7±5.9 years; range, 53 to 75 years) between June 2020 and June 2021. Drug-naive patients diagnosed with PD were included in this study. Those with PD and a Mini-Mental State Examination (MMSE) score >23 were defined as Group 1 (n=15), and those with PD and an MMSE score ≤23 were defined as Group 2 (n=15). Controls were included in Group 3 (n=15). The methylation changes of genes HSP70, HSP90, heat shock factor 1 (HSF1), heat shock RNA 1 (HSR1), and eukaryotic translation elongation factor 1 alpha (eEF1α) were investigated with methylation-specific real-time quantitative polymerase chain reaction analysis.
Results: The eEF1α was significantly more hypermethylated in Group 1. In Group 2, HSP70, HSP90 HSF1, HSR1, and eEF1α were significantly hypomethylated compared to Group 1 and Group 3 (for all genes p<0.001). The HSF1 hypomethylation was negatively correlated with MMSE and positively correlated with depression scores (p=0.03 and p=0.013, respectively). The correlation of eEF1α with MMSE and depression was the opposite of HSF1 (p<0.001 and p=0.013, respectively).
Conclusion: Cell line and autopsy studies indicate that eEF1α hypermethylation might be one of the main molecules triggering alpha-synuclein aggregation in the pathogenesis of PD. Therefore, eEF1α may be a molecule that can be used as a peripheral biomarker. The findings supported this idea as it was more hypermethylated in PD patients than in controls, whereas its negative regulator HSF1 was hypomethylated and correlated with the clinic. Furthermore, the worsening of cognitive functions and depression in PD patients may affect methylation levels of chaperone genes in the peripheral blood.
Association between lifestyle, metabolic syndrome and risk of Diabetes Mellitus in workers
Authors: Oliveira Renata Aparecida Rodrigues de , Amorim Paulo Roberto dos Santos , Miranda Valter Paulo Neves , Moreira Osvaldo Costa , Teixeira Robson Bonoto , Leite Luciano Bernardes , Cavaglieri Claudia Regina , Marins João Carlos Bouzas 
Published: June 2024

Background: The multivariate assessment of lifestyle can contribute to the identification of factors that are associated with diabetes mellitus (DM) and metabolic syndrome (MS). Objective: To evaluate the multivariate association of lifestyle, body composition, physiological measurements and sociodemographic information with DM and MS. Methodology: We conducted a descriptive study with a cross-sectional design, assessing 155 workers, with a mean age of 35.23 ± 10.22 years. We analyzed sex, body mass index (BMI), waist-hip ratio (WHR), waist-to-height ratio, body fat percentage (BF%), blood pressure, level of physical activity, risk of DM, readiness for physical activity (PAR-Q) and presence of SM. Result: The Multiple Correspondence Analysis showed that very high BF%, obesity (BMI), sedentary lifestyle, hypertension, and moderate risk of DM were correlated. However, regression analysis showed that workers with high WHR and obesity were, respectively, 9.22 (95% CI: 2.72-31.21) and 61.71 (95% CI: 6.68-569.9.21) more likely to have MS. According to PAR-Q, those who answered 'Yes' in the questionnaire were 12.52 (95% CI: 1.516-103.44) more likely to have a high risk of DM. Conclusion: There was a correspondence between the level of physical activity and risk factors for MS in the exploratory multivariate analysis.
ENFERMEIROS EM FORMAÇÃO ATUANTES NA I MOSTRA DE SAÚDE COLETIVA NO INTERIOR DO AMAZONAS: UM RELATO DE EXPERIÊNCIA
Authors: Cunha Keliane Venancio da , Silva Marilene Pereira da , Nunes Vivianny Kemelly de Souza , Nascimento Laura Beatriz Queiroz do , Costa Larissa Brito da , Silva Matheus Pedrosa da , Souza Christiany Gomes de , Cunha Thacyara Kaline Costa , Lima Naiza Peres de , Nunes Suzana dos Santos 
Published: June 2024

A Saúde Coletiva desenvolve diversas atividades, como o acolhimento individual e coletivo, ações educativas, coordenação de cargos técnicos na vigilância epidemiológica, ambiental, entre outros. Ao longo da graduação, é esperado que o estudante de enfermagem adquira competências para atuar na área de saúde coletiva. Desta forma, as instituições de ensino têm se esforçado para incluir em seus currículos os conhecimentos e as habilidades necessárias para formar profissionais aptos a trabalhar na saúde coletiva. Logo, o presente trabalho possui como objetivo principal relatar a vivência de acadêmicos de enfermagem na ação de extensão universitária intitulada “I Mostra de saúde coletiva do ISB/UFAM”. E assim, destacar a importância de atividades de extensão na saúde coletiva para formação acadêmico-profissional em enfermagem. Trata-se de um estudo descritivo do tipo relato de experiência, construído a partir da vivência na I Mostra de Saúde Coletiva realizada por acadêmicos do curso de Enfermagem do Instituto de Saúde e Biotecnologia. A interação entre profissionais de saúde, discentes e comunidade promoveu o desenvolvimento de habilidades práticas e a construção de novos conhecimentos, fortalecendo o aprendizado sobre saúde coletiva e a importância da extensão universitária. Assim, a ação de extensão não apenas superou as expectativas, mas também deixou um legado valioso de aprendizado e engajamento para todos os envolvidos.
Educational intervention strategy aimed at prenatal genetic risk care
Authors: Nuñez Millan Prisca Saray , Candelaria Gómez Belkys , Iglesias Rojas María Beatriz 
Published: June 2024

Introduction: Community genetics consultation has spread across the country. Genes and environment can influence the risk of genetic disease. It integrates strategies for prevention and detection of population genetic risk from primary health care.
Objective: To characterize the behavior of prenatal genetic risk and to design a genetic counseling strategy with community outreach on increased prenatal genetic risk.
Methods: A descriptive and retrospective cross-sectional study was carried out from January 2020 to December 2022 in the municipality of Consolación de Sur. The universe was constituted by 3887 pregnant women who had been admitted to the community genetic consultation and the sample consisted of 1863 women evaluated with increased risk. The processed information was shown in frequency distribution tables. Percentage analysis of the results and the Delphi method were used for the technical validation of the genetic counseling proposal based on its basic elements and ethical aspects.
Results: The pregnant women evaluated with increased genetic risk represented 47.92%, the most important risk being chromosomal alterations in 49.89%, followed by congenital defects in 32.51% and hereditary conditions in 11.57%. Extreme ages constituted a health problem, with adolescent girls 15.41% being the most frequent. We propose strategy to optimize attention to increased prenatal risk.
Conclusions: The evaluation of pregnant women allowed the identification of increased risk factors and the design of a genetic counseling strategy with a community approach, helping to improve prenatal care.
Systematic Review: Metformin, more than a hypoglycemic
Authors: Arce Julieta Lucila , Sabattini Analía Claudia 
Published: June 2024

Background: Metformin is a biguanide-type oral antidiabetic drug used in Type 2 Diabetes Mellitus (DM 2). Different uses of this drug are proposed in different pathologies, but in the 100 years since the drug became known, the only approved application is in DM2. The experience in off-label uses is relevant, but its scientific evidence and conclusions are limited, so the main objective of this systematic review is to investigate, analyze, and evaluate the beneficial uses of this drug for outside its regulated indication. Material and methods: A primary search was performed in MedLine, Embase, Google Scholar, and SCielo. Results: 13 articles were included where the pathologies of Polycystic Ovarian Syndrome (PCOS), Fragile X Syndrome, Hidradenitis Suppurativa, Acne, Psoriasis, Acanthosis Nigricans, Primary Myelofibrosis, Idiopathic Pulmonary Fibrosis, obesity and overweight and its use with antipsychotics were evaluated. Conclusion: The articles show that metformin caused improvement in pathologies such as Hidradenitis Suppurativa, Acanthosis Nigricans, Psoriasis and acne. Metformin works as a weight loss therapy. It is effective as prevention and treatment of weight gain in treatment with antipsychotics. In PCOS, metformin acts by reducing weight, improves hirsutism, and stimulates ovulation. In IVF and PCOS together with the use of metformin negatively affects pregnancy rates. Metformin does not reverse bone marrow fibrosis in patients with primary myelofibrosis. In the case of Idiopathic Pulmonary Fibrosis, it did not show improvement
Level of knowledge about Sexually Transmitted Infections Sexually Transmitted Infections among medical students at the Universidad Abierta Interamericana - Sede Rosario, year 2022
Authors: Rossi Agustina , Gustafsson Dra. Mónica , Tomarchio Dra. Daniela 
Published: June 2024

Introduction: Sexually transmitted infections (STIs) encompass a set of pathologies, belonging to different infectious etiologies, spread predominantly by sexual contact, whether vaginal, anal or oral sex. Young adults are part of the most vulnerable population where it is essential to strengthen prevention, awareness and education actions. Objective: To describe the level of knowledge about sexually transmitted infections in first year medical students of the Universidad Abierta Interamericana - Sede Rosario, 2022. Materials and methods: A quantitative, descriptive, observational, cross-sectional, prospective, quantitative study. Carried out at the Universidad Abierta Interamericana, Rosario campus. The population consisted of all 1st year students belonging to the School of Medicine and Health Sciences. The sampling was non-probabilistic by convenience. The data collection instrument consisted of an anonymous, voluntary and self-administered survey made up of 23 closed, multiple-choice questions with which the variables age, sex and level of knowledge were re-evaluated. The variables were analyzed through absolute and relative percentage frequencies and summarized through central position measures: mean, median and mode and dispersion measures: range and standard deviation. Results: A total of 178 students were surveyed, 100% of the students were in the 1st year of the course, with a mean age of 22.44 ± 4.40 years (min. 18; max. 48), of whom 116 (65%) were female and 62 (35%) were male. 97 (54%) students were not taking any STI-related subjects, 56 (32%) were taking one subject, 21 (12%) were taking two subjects and 4 (2%) were taking 4 subjects. The mean score was 13.64 ± 3.38 (min. 5; max. 20). 38% (67) of the students possessed a high level of knowledge about STIs, 40% (71) medium knowledge and 22% (40) low knowledge about STIs. Conclusions: Students have a medium-high level of knowledge about sexually transmitted infections in relation to definitions, forms of transmission and laboratory tests for the diagnosis of STIs and HIV. However, they present low knowledge regarding pathogens, clinical manifestations, treatment and complications of STIs
Level of knowledge about the Argentinean Decriminalization of Abortion in Argentina among students of the Medical School of the Universidad Abierta Interamericana -Sede Rosario inthe year 2023
Authors: Brunela Frade Melani , Kraft Dra. Florencia , Gabini Sebastián 
Published: June 2024

Introduction: Abortion is a medical procedure used to terminate a pregnancy, which is considered a guarantee of the right to a safe and free abortion for women, girls and other persons with gestational capacity to decide about their sexual and reproductive health. Objective: To describe the level of knowledge about the Argentinean Abortion Decriminalization Law among 4th and 5th year students of the Medical School of the Universidad Abierta Interamericana (UAI), Rosario campus, in the year 2023. Materials and methods: Quantitative, descriptive, observational, cross-sectional and retrospective study, carried out at the UAI. The study population consisted of all the students who attended the 4th and 5th year of the 1st four-month period of the Medicine course at the UAI - Rosario campus in the year 2023. The data collection instrument consisted of a 25-question survey, anonymous, voluntary and self-administered, consisting of open and closed questions. Quantitative variables were analyzed through absolute and relative percentage frequencies and summarized through central position measures: mean and dispersion measures: range and standard deviation, while qualitative variables were analyzed through absolute and relative percentage frequencies. Results: A total of 60 medical students were surveyed, 72% of whom were female and 28% male; the mean age was 26.38 ± 6.70 years. The mean age was 26.38 ± 6.70 years. 53% were in their 5th year of studies and 47% in their 4th year. Seventy-seven percent recognized up to what week access to voluntary termination of pregnancy is legal. 92% recognize that they can refuse to perform an abortion, but they must first make a conscientious objection. 98% can differentiate between legalized abortion and decriminalized abortion. 33% do not recognize the maximum time limit for performing an abortion once the will to perform it has been expressed, and 23% do not know that access to abortion is included in the mandatory medical program. Sixty-five percent obtained a high level of knowledge, 33% a medium level and 2% a low level. Conclusion: 65% of the students presented a high level of knowledge about the Argentinean Law on Decriminalization of Abortion, recognizing the necessary guidelines for access to voluntary termination of pregnancy, professional responsibility and the process of comprehensive care for those entitled to termination of pregnancy
The rol of bowel preparation in colorectal surgery
Authors: Briola Magali , Carballo Federico Héctor Enrique 
Published: June 2024

Background: Mechanical preparation of the colon has been an essential practice for colorectal surgery. During the 1930's it was popularized on the grounds that stool, due to its bacterial content, predisposed to surgical site infections and favored anastomotic dehiscence. To reduce the incidence of surgical site infections, the use of antibiotic prophylaxis associated with mechanical preparation has been recommended. After some years and experimental studies in animals, emergency surgeries without preparation and good results, its use was questioned, in fact, it was sought to avoid the discomfort and morbidity involved. With the advent of laparoscopic surgery, it was questioned again since it was believed that it was necessary to prepare the colon to be able to manipulate it, but later it was demonstrated that it was not necessary. The relevance of this paper is to illustrate the changes described in the last decades regarding colonic preparation and to update the reader on current recommendations. Despite the controversies over the years, the paradigm is continuously changing. Material and methods: A systematic review was carried out with a literature search in the following databases: Google Scholar, Cocharme Library, Espistemonikos and PubMed (MEDLINE). The MESH search terms used in the present study were colorectal surgery; Surgical preparation; anastomotic leakage; bowel preparation; antibiotic prophylaxis. The Boolean operators OR and AND were used. By selecting potential papers and important information to identify the best outcome in patients undergoing elective colorectal surgery, a total of 363 articles were identified, of which a total of 30 were potential articles for this review. Results. Nine articles were selected after application of the inclusion and exclusion criteria. A total of 14,015 patients were studied, 54.60% were men and 45.40% were women. The patients were divided into different groups, those who received only mechanical preparation of the colon, those who received mechanical preparation combined with oral antibiotics, those who received only oral prophylaxis and those who did not receive prophylaxis. Of the total number of studies analyzed, a clear reduction in complications was observed in the patients who received combined treatment. Conclusion: The combination of mechanical colon preparation and oral antibiotics would be associated with a lower incidence of surgical site infections and anastomotic leakage compared to no mechanical preparation
Metabolic syndrome and its components. Medical Clinic 26. Policlínico Luis Augusto Turcios Lima
Authors: Ramírez Guzmán Sandra , Capote Serrano Rigoberto 
Published: June 2024

Metabolic syndrome, initially defined by Reaven, is defined as the presence of a constellation of risk factors of metabolic origin affecting the same individual. Objective: to characterize the metabolic syndrome and its components in the population aged 45-59 years of the clinic 26 of the Policlínico Luis Augusto. Turcios Lima from September 2020 to April 2022. Method: an analytical, cross-sectional study of cases and controls was carried out, the universe was constituted by all patients between 45-59 years old, performing inclusion and exclusion methods, 135 patients were surveyed of which 45 presented metabolic syndrome (cases) and 90 patients did not present it (controls). Statistical tests of chi-square, Odd ratio and 95% CI were performed. Results: abdominal obesity in women was found to be significantly higher 97.4% than in men 73.7% (p=<0.0001), there was association between non-alcoholic fatty liver disease and metabolic syndrome (p=0.006) (OR=2.72; 95% CI: 1. 22- 6.08), abdominal circumference above the normal range is a predictor of metabolic syndrome (p=0.002, undefined OR, 95%CI undefined).Conclusions: abdominal obesity as a risk factor affects more the female gender. There is a close relationship between non-alcoholic fatty liver disease and metabolic syndrome. Abdominal obesity, arterial hypertension, hypertriglyceridemia and altered fasting glycemia are the risk factors most related to metabolic syndrome.
State administrative reparation to the victims within the framework of theJEP in the Municipality of Quibdo in the period 2018-2022
Authors: Perea Rivas Jaisser 
Published: June 2024

In order to establish any approach to reparation for victims, it is necessary to establish the context in which violence has developed in Colombia; Thus, two main moments and a context that precedes them are established. In Colombia during the last 70 years it has been a constant story in the nation, in Colombia historiography a milestone was caused with the death of the leader Jorge Eliecer Gaitán, an event which began the first phase of violence from a bipartisan tone. Subsequently, the second phase arises from an insurgent nature and finally the last phase is related to violence fueled by drug trafficking. In this last stage, which began in the 1980s, there was a growth of insurgent forces on the one hand and, in addition, an emergence of paramilitary forces. These are the armed actors that will seriously affect Colombian society and will have to be called transitional justice in this process.In the 1980s, the insurgent forces at the height of their growth made the strategic decision to kidnap notable people of high economic value, in addition to other crimes that violated fundamental human rights. So the guerrilla forces were the authors of the consolidation of their alternative or paramilitary forces, which tended to be financed by money from powerful people behind drug trafficking in the context of the 1980s, who constituted the counterproposal to the insurgency that at first it was called “Death to Kidnappers”, meanwhile the paramilitary forces received financing, training, equipment, weapons and political support from various sectors of society. So, in principle, it has been the serious effects that many independent actors in the conflict had that we want to repair in the contexts of demobilization processes, whether with paramilitary or guerrilla leaders. In that context of the 80s, several types of crimes were committed that would later be understood as victimizing acts, knowing in detail the scourges of kidnapping, torture, the dispossession of land, the commission of massacres, the forced disappearance of people, terrorism, among others. These are the same aspects that through transitional justice we hope to address, know and understand in order to advance as a Colombian society
Medical science education in COVID-19 times
Authors: Valido Valdes Doraimys , Hernández Villar Iris María , Fernandez Rojas Yoannia Caridad , Sánchez Rodríguez Yanely , Gallardo Romero Emma 
Published: June 2024

Introduction: In the year 2020 the World Health Organization (WHO)( WHO,2020), declared as a pandemic respiratory infectious infectious disease that was named coronavirus infectious disease-19 (Corona VIrus Disease 2019, known as COVID-19), first identified on December 12, 2019 in Wuhan. Aim: To describe the strategies implemented in universities of medical sciences worldwide and in South Consolation during COVID-19. Methods: a search of available evidence was conducted in Medline/Pubmed, Scopus, and EBSCO databases using the terms “COVID-19”, “medical education”, “SARS”, “MERS”, and “Medicine School”. Articles available as full text were reviewed and those detailing the strategies implemented during the SARS-CoV1, MERS, and Covid-19 epidemics were selected. Conclusions: the analysis of the strategies during the COVID-19 epidemic highlighted the importance of taking into account previous actions and adapting them to our reality. Developing our own strategies that achieved a greater interaction of students with the community and the family, with greater interaction with the teacher, teacher adaptation to the use of ICT, interaction of students with the municipal teaching department and the basic health team of each area, and close communication with students and parents, to have the largest number of virtual tools that allowed to cover the different learning styles.