bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical treatment and outcome of primary rib tumours in cats: eight cases (2016‐2023)
Authors: Cinti F. , Martano M. , Rossanese M. , Selmic L. E. , Fontes G. S. , Cino M. , Montinaro V. , Tremolada G. 
Published: August 2024

ObjectivesTo describe the clinical features and oncologic outcome for cats with primary rib tumours.Materials and MethodsMedical records for cats with surgically treated primary rib tumours from six veterinary referral centres were reviewed. Signalment, preoperative clinical signs, reconstruction technique, and surgical and oncologic outcome were retrieved from medical records or by telephone interview with owners and/or referring veterinarians.ResultsOf the eight cats with primary rib tumours, three had hemangiosarcoma, two had osteosarcoma and one cat each had chondrosarcoma, osteochondroma and osteoma. The size of the primary rib mass ranged from 2 × 2 × 1.6 cm to 9 × 7 × 7.5 cm. Three minor and one major complication developed during the immediate post‐operative period. Surgery consisted of thoracic wall resection in all cats. All animals survived the procedure and the median time to discharge was 3 days. The survival time for benign tumours was 150 (case 5) and 466 (case 4) days, while for malignant tumours ranged from 105 to 550 days (cases 1 to 3, cases 6 to 8).Clinical SignificanceHemangiosarcoma and osteosarcoma were the most represented primary rib tumours in this cohort of cats. Wide surgical excision and adjuvant chemotherapy is recommended for cats with hemangiosarcoma and osteosarcoma, but the prognosis remains guarded. Prognosis appears to be fair for the other tumour types.
Feline acute patient physiologic and laboratory evaluation scores and other prognostic factors in cats with first‐time diabetic ketoacidosis
Authors: Ad Yael , Hess Rebecka S. 
Published: August 2024

AbstractBackgroundAcute Patient Physiologic and Laboratory Evaluation (APPLE) scores have not been reported in cats with diabetic ketoacidosis (DKA).HypothesisIn cats with DKA, APPLE scores will be significantly higher in non‐survivors compared with survivors and these scores will predict mortality.AnimalsSixty‐eight cats with DKA.MethodsRetrospective study. The APPLE scores, blood glucose concentration (BG), venous pH, and ketone concentrations were compared between survivors and non‐survivors. Simple logistic regression was used to determine if these variables predict the binary variable of survival or non‐survival, and if they did, an empirical optimal cut point for mortality prediction was calculated.ResultsThe APPLEfast and APPLEfull scores were significantly higher in non‐survivors (30 cats; and , respectively) compared with survivors (38 cats; and ; P = .01 and P = .02, respectively). The APPLEfast (P = .03) but not the APPLEfull scores (P = .06) predicted mortality. For every 1 unit increase in the APPLEfast score, the odds of death increased by 1.08 (95% confidence interval [CI], 1.006‐1.17; P = .03). Median BG was significantly higher in non‐survivors (431 mg/dL; range, 260‐832 mg/dL) compared with survivors (343 mg/dL; range, 256‐738 mg/dL; P = .01) and BG predicted mortality (P = .02). For every 1 mg/dL increase in BG, the odds of death increased by 1.004 (95% CI, 1.0006‐1.008). Empirical optimal cut points for APPLEfast and BG mortality prediction were 24.5 and 358 mg/dL, respectively.Conclusions and Clinical ImportanceThe APPLEfast score and BG predict mortality in cats with DKA and can be used to stratify populations by risk of mortality in clinical trials of DKA in cats.
Antidiarrheal, anti‐inflammatory and antioxidant effects of Anethum graveolens L. fruit extract on castor oil‐induced diarrhea in rats
Authors: Brinsi Chirine , Jedidi Saber , Sammari Houcem , Selmi Houcine , Sebai Hichem 
Published: August 2024

AbstractBackgroundBetween food and medicine, nutraceuticals are widely used in human health for the prevention and treatment of various diseases. This study aims to determine the cytoprotective effects of Anethum gravelons fruit extract (AGFAE) on castor oil‐induced diarrhea in rats due to its phytochemical and antioxidant properties.MethodsMale rats were divided into six groups of six animals each: Control (C), Castor oil (CO), CO + different doses of AGFAE (50, 100, and 200 mg/kg, b.w., p.o.), and the CO + loperamide group (LOP, 10 mg/kg, b.w., p.o.).Key ResultsIn vitro, the chemical composition of aqueous Dill fruit extract showed strong antioxidant activity, with a high content of total polyphenols, flavonoids, and tannins. In our in vivo studies, pre‐treatment with AGFAE reduced malondialdehyde and hydrogen peroxide levels and maintained normal activity of enzymatic and non‐enzymatic antioxidants in the gastric and intestinal mucosa. In addition, we found that AGFAE prophylaxis improved the stability of many plasma biochemical parameters altered by castor oil intoxication, such as C‐reactive protein concentrations and alkaline phosphatase activities.Conclusions & InferencesWe suggest that AGFAE phenolic compounds had significant protection against diarrhea involving several mechanisms such as reducing hypersecretion, peristaltic, inflammation, and preserving the endogenous antioxidant levels.
Rheological sand bed generates non‐rebounding particles
Authors: Wang Zhengshi , Li Zhi , Jia Shuming 
Published: August 2024

ABSTRACTWind‐blown sand movements induce desertification and cause various environmental problems. This study investigates the rebound probability of sand particles during sand transport. The widely used rebound probability models are essentially empirical and the mechanism that generates non‐rebounding particles remains unclear. By tracking the grain–bed collision process of impact particles in steady‐state sand flows, it was observed that non‐rebounding particles undergo repetitive collisional momentum losses within the rheological layer of the sand bed. Therefore, rebound probability models based on the incident velocity and angle cannot realistically describe rebound probability. Furthermore, the rheological sand bed produces numerous rebound particles with a coefficient of restitution above 1.0, converting the normal distribution of the coefficient of restitution into a lognormal distribution pattern with considerably larger variances. The new insights into aeolian rebounds gained through this study are expected to reduce the uncertainties in sand flux predictions.
Revealing an association between HPV and systemic lupus erythematosus: A bidirectional two‐sample Mendelian randomization study
Authors: Pan Fangfang , Shen Huiliang , Wang Ben , Wang Jian 
Published: August 2024

AbstractBackgroundAn increasing number of studies have focused on the association between Human papillomavirus (HPV) infection and systemic lupus erythematosus (SLE). However, current evidence is largely based on retrospective studies, which are susceptible to confounding factors and cannot establish causation.MethodsA bidirectional two‐sample Mendelian randomization (MR) design was used to evaluate the causal relationship between HPV and SLE. Mononucleoside polymers (SNPS) with strong evidence for genome‐wide association studies (GWAS) were selected from the HPV exposure dataset and used as an instrumental variable (IV) for this study. For the MR Analysis results, the MR‐Egger intercept P test, MR‐Presso global test, CochranQ test and leave‐one test were used for sensitivity analysis.ResultsBased on the evidence of MR Analysis, this study finally determined that there was no causal association between HPV16 and HPV18 and SLE.ConclusionsPossible regulation of HPV infection is not significantly associated with regulation of SLE. These findings provide new insights into the underlying mechanisms of HPV and SLE and need to be validated by further studies.
Identification of potential therapeutic targets for skin cutaneous melanoma on the basic of transcriptomics
Authors: Shi Fengling , Li Tao , Shi Huiling , Wei Yushan , Wang Juan , Liu Canyu , Liang Ruirong 
Published: August 2024

AbstractBackgroundAdvanced skin cutaneous melanoma (SKCM) is responsible for the majority of skin cancer‐related deaths. Apart from the rare BRAF V600F mutation, which can be targeted with specific drugs, there are currently no other novel effective therapeutic targets.MethodsWe used SMR analysis with cis‐expressed quantitative trait locus (cis‐eQTL) as the exposure variable and SKCM as the outcome variable to identify potential therapeutic targets for SKCM. Colocalization assays and HEIDI tests are used to test whether SKCM risk and gene expression are driven by common SNPs. Replication analysis further validated the findings, and we also constructed protein–protein interaction networks to explore the relationship between the identified genes and known SKCM targets. Drug prediction and molecular docking further validated the medicinal value of drug targets. Transcriptome differential analysis further validated that there were differences between normal tissues and SKCM for the selected targets.ResultsWe identified 13 genes significantly associated with the risk of SKCM, including five protective genes and eight harmful genes. The HEIDI test and co‐localization analysis further indicates a causal association between genes (SOX4, MAFF) and SKCM, categorized as Class 1 evidence targets. The remaining 11 genes, except for HELZ2 show a moderately causal association with SKCM, categorized as Class 2 evidence targets. Target druggability predictions from DGIdb suggest that SOX4, MAFF, ACSF3, CDK10, SPG7, and TCF25 are likely to be future drug targets.ConclusionThe study provides genetic evidence for targeting available drug genes for the treatment of SKCM.
Wave Energy Farm Assessment in Real Wave Climates: The North Sea
Authors: Raghavan Vaibhav , Alday G. Matias , Metrikine Andrei , Lavidas George 
Published: August 2024

Abstract
Wave energy has immense potential and can provide at least twice as much electricity as globally produced now due to its high energy density. Apart from the vast accessibility of the resource, waves are more predictable and available throughout the year when compared to other forms of renewable energies. This makes the development and utilization of wave energy technologies immensely important, in order to meet the renewable energy targets, an example of which is the 40GW by 2050 set as the offshore energy strategy of the European Commission. For wave energy to become a commercially viable power source, individual wave energy converters (WECs) need to be deployed in large numbers similar to what can be seen in the wind industry. Therefore, numerical tools simulating multiple interacting devices becomes highly relevant. This research utilizes the new open-source Boundary Element Method (BEM) based solver HAMS-MREL to analyse the hydrodynamic interactions of mono-array farms of point absorbers inspired by the state-of-the-art Corpower C4 point absorber device in various configurations subjected to waves in different directions. The obtained responses are used to estimate the power absorbed by the arrays in different configurations to obtain the Array Power Matrices, which can be used to study the variability of the q-factors in different sea states and different directions. Furthermore, the obtained Array Power Matrices are used to estimate the power absorbed by the array configurations in the North Sea. This can be a powerful tool for the analysis of the best wave energy farm configurations as it employs a computationally efficient frequency domain-based solver.
Comparison of Methods for Seismic Response Analysis of an Offshore Jacket Platform Located in Bohai Bay, China
Authors: Wu Mengning , Dai Guohua , Pang Honglin , Wu Jingjian , Li Xiangyun , Liang Peng 
Published: August 2024

Abstract
As designing offshore jacket platforms in seismically active regions, it is imperative to account for the seismic-induced loads on the structure. In this study, seismic structural analysis of an offshore jacket platform located in Bohai Bay, China is conducted using the response spectrum analysis (RSA) method and the time history analysis (THA) method. The structural dynamic responses are compared and the applicability of the two methods in the seismic design of jacket platform is assessed. Furthermore, a sensitivity study is conducted to investigate the effects of earthquake strengths, deck weights and pile diameters on the structural seismic responses using the two analysis methods. Typical results revealed that the RSA method is the preferred choice for seismic design when it comes to offshore jacket platforms situated in regions characterized by low seismic ground motions. Nonetheless, in regions with high seismic intensity levels, a more precise method should be contemplated. In such scenarios, the THA method is preferred, by conducting the nonlinear dynamic response analysis to account for the seismic-induced excitation loads. This approach has the potential to lead more efficient and cost-effective pile and platform designs.
Optimal Mooring Pattern for a Semi-Submersible FOWT in a Typhoon Environment
Authors: Ivanov Glib , Wu Yongyan , Chen DongHui , Lai Zhao-Yu , Chen Jui-Chen , Gladkov Nikolai , Ma Kai-Tung 
Published: August 2024

Abstract
The scarcity of suitable shallow waters for fixed-bottom offshore wind turbines has prompted developers to explore deeper waters, albeit with caution due to the significant capital expenditure (CAPEX) associated with Floating Offshore Wind Turbines (FOWTs). A major cost component in FOWTs is the mooring system, a concern exacerbated in regions with the presence of typhoons, necessitating a more robust and therefore expensive 3 × 3 mooring solution compared to 3 × 1 in areas such as the North Sea. This study tried to propose a 3 × 2 mooring arrangement tailored for FOWTs in the typhoon region, offering a potential cost reduction of up to one-third compared to the original 3 × 3 configuration.
To achieve cost savings, an in-depth analysis of spreading angles from 10° to the widest angle of 126° is performed using the pre-tension-diameter vs offset-tension 3D response surfaces technique. The research reveals that, theoretically, a 60° mooring angle minimizes floater offset with the least tension. However, the discrepancy in safety factors between intact and damaged conditions makes grouped mooring a more cost-effective choice. Utilizing the American Bureau of Shipping (ABS) safety factor, a 10° spread angle mooring system’s chain cost emerges as roughly one-tenth cheaper than alternative configurations.
Additionally, the study explores an innovative V-Share mooring [1], wherein a single pile anchor connects to two different columns via two mooring lines. Depending on the anchoring conditions, it can be the most cost-effective.
In conclusion, a 3 × 2 mooring pattern for a 15MW semi-submersible FOWT in typhoon regions might be theoretically achieved on paper. However, it may not be practically achieved, if the size limit of the manufactured chain is considered.
Coupled Analysis of External Dynamics and Internal Mechanics in Ship-Floating Bridge Collision Studies
Authors: Wang Zihao , Sha Yanyan , Jakobsen Jasna Bogunović 
Published: August 2024

Abstract
Ship collisions with floating bridges in the navigation area are complex processes involving highly nonlinear dynamics, large structural deformations, and fluid-structure interactions (FSI). In the traditional approach for collision analyses, the external dynamics and internal mechanics of the ship-bridge system are treated independently. Limitations have been reported for this decoupled method in predicting the structural responses during oblique collisions. This study introduces an algorithm to integrate the external dynamics and internal mechanics in ship-floating bridge collision studies, addressing the complexities of a multibody system. The external dynamics of a traveling ship colliding with a floating bridge is modeled using OrcaFlex, while the internal mechanics is simulated in LS-DYNA. Through the developed algorithm, two analyses are conducted interactively. The algorithm incorporates the considerations of hydrodynamic forces acting on the floating bodies, their six degrees of freedom (6DOF) motions, and the structural internal forces within the multibody system. The simulation results reveal that the collision forces, effective stress, plastic strain of the striking ship and the struck pontoon, as well as the energy dissipation, are sensitive to the boundary conditions applied to the pontoon.
Structural Integrity Analysis of Marine Dynamic Cables
Authors: McCormick Robbie , Fagan Nicholas , Stewart Greg , Marwood Tom , Ringsberg Jonas W. , Li Zhiyuan 
Published: August 2024

Abstract
Offshore power cables are typically designed to have a service life of around twenty-five years. A pattern is emerging where these cables only last ten years or even as little as two. The main consensus as to why the service life is so short is due to a combination of fatigue and fretting/wear damages of the copper conductors and water treeing in the insulation material. This study presents a method that can be used to analyse the structural integrity of dynamic subsea power cables and estimate their service life determined by the factors above. The numerical simulation models developed and used to carry out global and local fatigue analysis of dynamic subsea power cables are presented, together with methods and models for assessing fretting, wear and growth of water tree defects. A methodology for structural integrity assessment that includes all these factors is proposed. A dynamic subsea power cable connected to a wave energy converter is used as the case study for comparison of the service life when these factors are considered compared to when, e.g., the growth of water trees is excluded.
Cyclic Cohesive Zone Model (CCZM)-Based Fatigue Crack Initiation Prediction for a Mooring Chain
Authors: Song Zhi-Hao , Chen Nian-Zhong , Zheng Tingsen 
Published: August 2024

Abstract
Offshore mooring chains are generally subjected to cyclic loads induced by the ocean environment and fatigue failure of mooring chains occurs with high frequency. For safety reason, it is necessary to perform fatigue assessment for offshore mooring chains during the design phase. In this study, a cyclic cohesive zone model (CCZM) is constructed for fatigue crack initiation prediction for a mooring chain. Different from the traditional approaches such as S-N curves and T-N curves, the material fatigue is regarded as an irreversible and continuous process and it can continuously take into account stiffness degradation of the material and non-linear accumulation of fatigue damage during the fatigue process. In the cyclic cohesive zone model, the constitutive equation called as traction-separation law is adjusted to linear unloading according to the stress states of a mooring chain, and the accumulated fatigue damage is then measured by a damage evolution equation where the fatigue damage is quantified by material deformation weighted by loading. A case study on fatigue crack initiation prediction for a mooring chain is performed to demonstrate the capability of the cyclic cohesive zone model. The life of fatigue crack initiation predicted by the cyclic cohesive zone model is then compared with experimental data and the life calculated by method from industrial standard. Furthermore, an analysis is carried out to predict the fatigue crack initiation of a mooring chain with a corrosion pit. Results of this study demonstrate that the cyclic cohesive zone model has the capability to reasonably predict the fatigue crack initiation of an offshore mooring chain.
Numerical Simulation of a Semi-Taut Moored Floating Offshore Wind Turbine Under a Mooring Line Failure in Shallow Waters
Authors: Tang Hung-Jie , Li Di-Rong , Yang Ray-Yeng , Hsu Tai-Wen 
Published: August 2024

Abstract
The potential sites for floating offshore wind turbines (FOWTs) in Taiwan are mostly located in shallow water depths ranging from 50 m to 100 m. Recent studies reveal that semi-taut mooring appears to be a feasible solution for FOWTs in shallow waters. However, the potential area is also one of the busiest navigation channels in the world, indicating that the issue of mooring line failure should be carefully considered. Thus, this study aims to investigate the feasibility of a semi-taut mooring configuration applied to FOWTs in shallow waters and the impact of mooring line failure on it. For this study, the 15 MW semi-submersible FOWT reported by the International Energy Agency (IEA) is adopted, equipped with three mooring lines. The study area is situated at a water depth of 70 meters off northeast Taiwan, and the extreme sea state is a combination of a 50-year return period of irregular waves, wind, and current. Comparison results among the catenary chain and two types of semi-taut mooring (Polyester and nylon) demonstrate that both semi-taut mooring configurations notably decrease the probability of touchdown points nearing anchor locations and substantially reduce the maximum load. Additionally, they reduce surge and pitch responses but increase heave responses, with little differences in other degrees of freedom. The comparison results of upstream mooring line failure on the three mooring configurations indicate that after the failure, the semi-taut mooring reaches balance states faster, but the drift distance of the catenary chain is shorter. In conclusion, the two semi-taut moorings could be considered as viable and superior solutions for FOWTs in the shallow water areas of Taiwan.