bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Antiepiligrin Cicatricial Pemphigoid with Nephrotic Syndrome
Authors: Uchino Yuri , Kanekura Takuro , Takeda Koichiro , Shimada Hidehiko , Inoue Mistuse , Hashimoto Takashi , Kanzaki Tamotsu 
Published: July 2014

AbstractWe report a 71‐year‐old woman with antiepiligrin cicatricial pemphigoid associated with nephrotic syndrome. She presented with a six‐month history of pruritic blisters over her trunk and legs. She also had episodes of recurrent painful oral erosions. A skin biopsy showed a subepidermal bulla, and a direct immunofluorescence (DIF) study revealed linear deposition of IgG and C3 at the basement membrane zone (BMZ). Indirect immunofluorescence (IIF) staining of 1 M NaCl‐split skin demonstrated circulating IgG autoantibodies reactive with the dermal side. Immunoprecipitation studies of the patient's serum disclosed IgG autoantibodies directed against a set of polypeptides that corresponded to laminin 5 (β3γ2). Based upon the long‐standing edema of her legs and her hypoproteinemia, she was diagnosed with nephrotic syndrome. To our knowledge, the association of antiepiligrin cicatricial pemphigoid with nephrotic syndrome has not been reported previously.
Immunoregulation of Allergic Contact Dermatitis
Authors: Girolomoni Giampiero , Gisondi Paolo , Ottaviani Chiara , Cavani Andrea 
Published: July 2014

AbstractAllergic contact dermatitis (ACD) to haptens can serve as a valuable paradigm for understanding the physiopathology of T cell mediated immune responses. In sensitized individuals, exposure to the relevant hapten initiates clinical expression of ACD, which depends on the rapid activation of specific T cells. Mechanisms of tissue damage include direct cytotoxicity against keratinocytes, mostly mediated by CD8+ T cells, and T cell release of cytokines, which amplify the inflammatory response by targeting resident skin cells. The expression of ACD is actively regulated by specialized subsets of T lymphocytes with suppressive functions. In particular, T regulatory cells producing high levels of IL‐10 suppress ACD by blocking the functions of dendritic cells. In contrast CD4+CD25+ regulatory T cells prevent immunopathological reactions and maintain peripheral tolerance to haptens by acting via a cell‐to‐cell contact mechanism. Understanding the role of suppressor T cells and the requirements for their in vivo and in vitro expansion are critical steps for the development of specific desensitization protocols in hapten‐allergic individuals. This information may also provide the basis for novel interventions in other immune‐mediated diseases.
Dosage and Adverse Effects of Topical Tacrolimus and Steroids in Daily Management of Atopic Dermatitis
Authors: Furue Masutaka , Terao Hiroshi , Moroi Yoichi , Koga Tetsuya , Kubota Yumiko , Nakayama Juichiro , Furukawa Fukumi , Tanaka Yoichi , Katayama Ichiro , Kinukawa Naoko , Nose Yoshiaki , Urabe Kazunori 
Published: July 2014

AbstractSince 1999, combination therapy with tacrolimus and topical steroids has been widely used for the treatment of adolescent/adult‐type atopic dermatitis. In order to determine the clinical doses of topical tacrolimus and steroids for daily treatment of atopic dermatitis and to elucidate their beneficial and adverse effects, we analyzed the clinical data from 215 patients with atopic dermatitis who were more than 16 years old. Less than 70g of tacrolimus and less than 15 g of steroids were applied to 90% of the patients on the face and neck, and less than 75.8 g of tacrolimus and less than 322 g of steroids were applied to 90% of the patients on the trunk and extremities during the six‐month treatment period. Topical tacrolimus is much more frequently used on face and neck lesions (99.1%); in only 39.5% of cases was it used on the trunk and extremities. The majority of patients improved after six months of the combination topical therapy; however, atopic dermatitis was not controlled in 6% of the patients. The combination therapy did not seem to increase the risk of cutaneous infections; however, the incidence of herpes simplex infection on the face and neck was 2.8% at pre‐treatment and slightly increased to 4.7% during the therapy. The incidence of all steroid‐induced adverse effects was reduced both in frequency and intensity with a decrease in the dose of topical steroids through simultaneous tacrolimus application. Combination therapy with topical tacrolimus and steroids is useful for treating atopic dermatitis, but a small percentage of the patients still cannot be satisfactorily treated. For such patients, adjustments of the dose and rank of topical steroids and tacrolimus and other therapeutic adjuncts are necessary.
Cutaneous Involvement in Hodgkin's Lymphoma: Report of Two Cases
Authors: Erkılıç Suna , Erbağcı Zülal , Koçer N. Emrah , Bayazıt Yıldırım A. , Camcı Celalettin 
Published: July 2014

AbstractHodgkin's lymphoma (HL) comprises 20 to 30% of all lymphomas. Skin involvement is almost always secondary to visceral or nodal involvement. Secondary cutaneous HL is rare, occurring in only 0.5 to 3.4% of the cases. Herein we report two cases of skin involvement in Hodgkin's disease. One was a 25‐year‐old female admitted with a draining sinus in the neck. The other was a 19‐year‐old female admitted with a neck mass and skin papules on her chest and arm. Skin involvement may antecede or can be seen during the course of HL. Better understanding of such cutaneous involvement, which occasionally may be the initial sign of HL, is needed, and a biopsy of any suspicious skin lesion should be considered.
Successful Treatment of Pyogenic Granuloma with Injection of Absolute Ethanol
Authors: Ichimiya Makoto , Yoshikawa Yoshiaki , Hamamoto Yoshiaki , Muto Masahiko 
Published: July 2014

AbstractPyogenic granuloma (PG) is a small, almost always solitary, sessile or pedunculated, raspberry‐like vegetation of exuberant granulation tissue. Conservative treatment by techniques such as cryosurgery, laser surgery, and electrodesiccation are usually adequate, whereas excisional treatment can often result in noticeable scars. We attempted a different approach using an injection of absolute ethanol in five patients with recurrence due to inadequate cryosurgery. This therapy is less invasive than surgical excision and appears to be an alternative therapy for PG.
c‐Myc and Epidermal Stem Cell Fate Determination
Authors: Honeycutt Kimberly A. , Roop Dennis R. 
Published: July 2014

AbstractThe epidermis is sustained by a multipotent stem cell population that gives rise to cells of different fates including those forming hair follicles, interfollicular epidermis and associated glands such as sebaceous glands. The most intriguing evidence comes from using a variety of mouse models with which studies have found the WNT pathway to be involved in regulating stem cell fate decisions. These mouse models have been used to analyze different members of the WNT pathway in the epidermis and altogether suggest that different levels of β‐catenin correlate with the adoption of different epidermal stem cell fates. Recent data specifically analyzing c‐Myc, a downstream target of the WNT pathway, has found that c‐Myc can divert epidermal stem cells to a sebaceous gland fate at the expense of hair follicles. Also, newly emerging data using gene expression profiling techniques have uncovered a more direct role of c‐Myc in stem cell fate determination.
Detection of the Levels of Neuropeptides, ACTH and Cortisol in the Blood of Patients with Polymyositis/Dermatomyositis and Their Significance
Authors: Liu Jifeng , Li Jiuhong , Zhai Ning , Geng Long , Song Fangji 
Published: July 2014

AbstractRecent research has shown that the neuroendocrine system can regulate the function of the immune system and that ACTH and cortisol play important roles in maintaining the immune homeostasis. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with unclear pathogeneses closely related with immune disorders, so we detected the levels of neuropeptide Y (NPY), beta‐endorphin (β‐EP), calcitonin gene‐related peptide (CGRP), adrenocoricotropic hormone (ACTH), and cortisol in blood of patients with PM/DM to investigate the relationship between these indices and the pathogenesis of PM/DM. The detection of NPY, β‐EP, CGRP, and ACTH concentrations in plasma and cortisol in serum of 28 cases of PM/DM was carried out using radioimmunoassay methods, and the results were compared with those of 20 normal controls. The levels of NPY in the plasma of PM/DM was significantly higher than those of the controls, while β‐EP, CGRP and ACTH were significantly lower than those of the controls, and cortisol was not significantly different before treatment. Linear correlation analysis indicated that NPY was significantly positively correlated with CPK, and β‐EP and CGRP were significantly negatively correlated with CPK. There were no significant correlations among cortisol ACTH, and CPK and no significant correlations between NPY, β‐EP, CGRP, ACTH, cortisol and age or duration of disease before treatment. After treatment for three months, NPY, β‐EP and CGRP tended to become normal and no longer significantly different from the control values. However, ACTH fell further and was significantly lower than the level before treatment. Therefore the increase in NPY and the decreases in β‐EP, CGRP, and ACTH in the plasma of PM/DM patients may be related to the pathogenesis of PM/DM.
A Case of Docetaxel‐Induced Erythrodysesthesia
Authors: Katoh Mayumi , Kadota Masafumi , Nishimura Youichi 
Published: July 2014

AbstractChemotherapy‐induced acral erythema (CIAE) is a rare cutaneous reaction to high‐dose chemotherapy, clinically featuring painful erythema on the palms and soles. Docetaxel (Taxotere®), an anticancer agent, is known to cause various reactions, including CIAE. We experienced a case of docetaxel‐induced acral erythema with facial edematous erythema that coincidentally emerged and regressed with appearance and disappearance of the acral lesions. Docetaxel‐induced acral erythema exhibits a widespread distribution and intense sensations of intolerable pain and numbness. Therefore, some authors use the term erythrodysesthesia instead of acral erythema. We speculated that the facial erythema might be part of the spectrum of erythrodysesthesia. Our case was finally diagnosed as decetaxel‐induced erythrodysesthesia. Although CIAE is self‐limiting, the patients frequently require treatment because of intolerable pain. Reported treatments for CIAE include topical or systemic steroids, elevation of the legs, and application of cold compression to the lesion. In our case, application of a steroid ointment with the occlusive dressing technique (ODT) alleviated the clinical manifestations and was also prophylactic for the erythrodysesthesia.
Phakomatosis Pigmentovascularis Type IIB: A Case Report
Authors: Theng Thiam Seng Colin , Sujith Prasad W. Kumarasinghe 
Published: July 2014

AbstractPhakomatosis Pigmentovasularis (PPV) is a rare condition defined by the presence of both vascular and melanocytic nevi occurring in the same patient. We report the case of a 27‐year‐old Chinese female who presented with generalized port‐wine stains over the left trigeminal region, trunk, and limbs, diffuse dermal melanosis on the back, nevus of Ota on the right cheek, and scleral melanosis. Her port‐wine stain on the trunk was distributed in a checker‐board pattern. She was otherwise well. She was diagnosed with phakomatosis pigmentovascularis (PPV) Type IIb. The ‘twin spotting’ phenomenon has been proposed in the pathogenesis of PPV, and PPV is an example of non‐alleleic twin spotting. The checkerboard distribution of port‐wine stain in our patient follows the type II pattern of distribution in cutaneous mosaics. This lends further credence to the proposed hypothesis of twin spotting and cutaneous mosaicism in the pathogenesis of PPV.
Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts: Report of a Case and Review of the Literature
Authors: Fujiwara Masao , Yuba Yoshiaki , Wada Akihiko , Ozawa Toshiyuki , Tanaka Toshihiro 
Published: July 2014

AbstractWe present the case of a 69‐year‐old man with a subcutaneous pleomorphic hyalinizing angiectatic tumor of soft parts on the back. In addition to its rare localization, it showed unique clinical features of an exceptionally long history. Histological characteristics of this tumor showed thin‐walled angiectatic blood vessels lined with a thick eosinophilic and hyalinotic amorphous material. Tumor cells are composed of pleomorphic cells. It was surgically removed, and there was no recurrence by 11 months postoperatively.
A Case of Black Dot Ringworm Attributable to Trichophyton violaceum: A Simple Method for Identifying Macroconidia and Microconidia Formation by Fungi‐Tape™ and MycoPerm‐Blue™
Authors: Ogasawara Yumie , Hara Joko , Hiruma Masataro , Muto Masahiko 
Published: July 2014

AbstractAn 85‐year‐old Japanese woman sought a dermatologic consultation for evaluation of a walnut‐sized alopecia with pityroid desquamation in the parietal region of her scalp. She had been admitted to a nursing home about three months earlier, and, at that time, a thumb‐tip‐sized, scaly alopecia was noted. Several hairs at the site were eroded in a black dot. Direct KOH microscopy of affected hair showed large spore endothrix infection. To isolate macro‐ and microconidia for fungal identification, we incubated the affected hair and scales and obtained giant colonies in a special enriched medium. Using Fungi‐tape™ and MycoPerm‐Blue™, we were able to collect and identify Trichophyton violaceum macro‐ and microconidia from the white, powdery, fluffy colony that slowly developed after about six weeks of growth on enriched medium. Over the past 20 years, only about 20 cases of tinea capitis caused by T. violaceum have been reported in Japan, and macroconidia have been identified in only 4 cases, including this one.
Allergic Contact Dermatitis to White Petrolatum
Authors: Kang Hee , Choi Jun , Lee Ai‐Young 
Published: July 2014

AbstractWhite petrolatum is known for its nonsensitizing and nonirritating properties. Only a few cases of allergic contact dermatitis to white petrolatum have been reported. Although it is a rare event, the finding of contact sensitization to white petrolatum raises the potential problem of its usage of common topical agents or vehicles for patch testing. We herein report a case of allergic contact dermatitis to white petrolatum.
A Study of Immunohistochemical and Electron Microscopic Changes in Dowling‐Degos Disease
Authors: Zhang Ru‐Zhi , Zhu Wen‐Yuan 
Published: July 2014

AbstractPrevious investigations have focused on the skin manifestations, histopathology, and pedigree of patients with Dowling‐Degos disease (DDD). Little is known about its immunohistochemical staining, and electron microscopy. Our purpose was to study the immunohistochemistry and electron microscopy of lesions from patients with DDD. A biopsy specimen revealed elongated epidermal rete ridges with basilar hyperpigmentation in a filiform pattern. All pigmented cells in the basal layer were recognized by Anti‐PEP‐1, anti‐PEP‐2, HMB‐45 and NKI/beteb antibodies. The melanocytes were localized in the basal layer and accounted for 10% of the total keratinocytes. There were supranuclear “caps” of brown granules within most basal kerotinocytes in the hyperpigmentation area. The melanocytes contained many mitochondria, Golgi apparati, and regular melanosomes in all stages of maturation in their cytoplasms; melanosome‐laden dendrites were readily detected by transmission electron microscepe. Melanosomes, mainly of stages III and IV, were present within keratinocytes, distributed either as scattered patterns or forming “caps” over the nucleus.
Coexistence of Neurofibromatosis 1 and Chiari Type I Malformation: An Unusual Association
Authors: Hara Hiroyuki , Arakawa Hiroshi 
Published: July 2014

AbstractNeurofibromatosis 1 (NF‐1) is a relatively common, autosomally dominant disorder, comprised of characteristic skin lesions. NF‐1 is also associated with a variety of cerebral dysplasias. We describe a patient with both NF‐1 and Chiari type I malformation. The frequency of this correlation depends on the magnetic resonance imaging (MRI) findings in patients with NF‐1, because some cases of Chiari malformations are asymptomatic. Awareness and further observation of this unusual association are required, and Chiari type I malformation should be added to the differential diagnosis of the central nervous system dysplasias in patients affected by NF‐1.
Vibrio vulnificus Septicemia Presenting as Purpura Fulminans
Authors: Choi Hye‐Jin , Lee Dong‐Kyung , Lee Mi‐Woo , Choi Jee‐Ho , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: July 2014

AbstractWe present a case of Vibrio vulnificus septicemia presenting as purpura fulminans, which can often result in a catastrophic course. This case had a fortunate outcome due to immediate and intensive empirical antibiotic treatment and the relatively healthy condition of the patient. We focused on the prognostic factors for the relatively good outcome in this patient.
Neonatal Lupus Erythematosus: A Review of the Racial Differences and Similarities in Clinical, Serological and Immunogenetic Features of Japanese versus Caucasian Patients
Authors: Miyagawa Sachiko 
Published: July 2014

AbstractThere has been tremendous interest in neonatal lupus erythematosus (NLE) since the reports of anti‐Ro/SSA antibodies as a diagnostic marker. Recent studies, including ours, have revealed racial differences as well as similarities in the clinical features and immunogenetic backgrounds of Japanese and Caucasian patients with NLE. The frequency of photosensitivity and subacute cutaneous LE lesions is not high in Japanese infants with NLE, which is in sharp contrast to their Caucasian American counterparts. The majority of Japanese infants with NLE develop annular, erythematous or edematous lesions which have also been reported in association with Sjögren's syndrome. The frequency of isolated congenital heart block (CHB) is about 50% in Japanese anti‐Ro/SSA positive neonatal lupus infants; this is similar to the frequency among Caucasians. The HLA‐DR3 phenotype, which is found in the great majority of Caucasian mothers of NLE infants, is absent in Japanese mothers. Finally, both Japanese and Caucasian children with CHB are often identical to their mothers in their alleles of HLA‐DRB1, DQA1 and DQB1 loci.
Prevalence of Skin Diseases among Male Adolescent and Post‐Adolescent Boarding School Students in Turkey
Authors: Tuncel A. Almila , Erbagci Zülal 
Published: July 2014

AbstractSkin disease is a common problem in boarding schools and may account for significant morbidity. To document the prevalence and patterns of skin diseases among male adolescent and post‐adolescent boarding school residents, a cross‐sectional epidemiologic survey was performed. A total of 682 students were examined for evidence of any skin disease, and subjects with skin disease(s) were also asked to fill in a questionnaire. Of the study population, 378 (55.42%) had at least one skin disease. The most prevalent diseases were tinea pedis (32.5%), acne vulgaris (28.6%), onychomycosis (8.06%), androgenetic alopecia (5.6%), common warts (5.3%), unguium incarnatus (4.1%), irritant hand dermatitis (3.6%), foot callosities (3.6%), and pitted keratolysis (2.6%). Of those with skin problem(s), 245 (65%) were not aware of their disease(s) and 45% of the remaining 133 subjects who were aware of their disease(s) had not sought medical help. We concluded that skin diseases, especially foot problems, are very common among male boarding school students. In additional to monitoring the epidemiology of skin diseases, intermittent medical education programs for both health‐care workers and residents living in these communities would be useful for enhancing knowledge of available and effective treatments and implementing appropriate preventive measures.
Squamous Cell Carcinoma of the Penis in a Man with a Human Papilloma Virus 31 Infection
Authors: Hama Naoto , Ohtsuka Tsutomu , Yamazaki Soji 
Published: July 2014

AbstractWe report a 51‐year‐old man with squamous cell carcinoma (SCC) on his penis. He was surgically treated for his phimosis when he was 20 years old. He presented with an indurated nodule on the tip of his penis. The tumor was treated with partial penectomy and standard inguinal lymphadenectomy. Histological examination revealed that the tumor was a well‐differentiated type of SCC. A polymerase chain reaction was performed to detect human papilloma virus (HPV) DNA. The result revealed the presence of HPV in the SCC. The results of sequencing analysis showed that the DNA was HPV 31.
Multiple Plaques on the Back: S‐100 Negative Benign Granular Cell Tumor
Authors: Arican Ozer , Ciralik Harun , Sasmaz Sezai 
Published: July 2014

AbstractGranular cell tumor is a rarely seen disease characterized by a gradually developing nodular lesion, which is difficult to diagnose. It has been thought to originate from Schwann cells. The tumor usually appears in the 4th–6th decades of life, more frequently in women and blacks, and has a multifocal location in 10–25% of the cases. The malignancy potential is 1–3%, with 70–74% of the cases in women. Ninety‐eight percent of the cases are S‐100 positive. The present paper describes an 18‐year‐old female patient with benign granular cell tumor. This rarely seen type of tumor was S‐100 negative and has been detected in biopsies taken from multiple asymptomatic plaques and maculopapular lesions. They were 0.5–4 cm in diameter, light brown in color, and with clear contours and had been gradually growing on her back the last nine years.
Blue Rubber‐Bleb Nevus Syndrome: Report of a Case Associated with Osteoid Osteomas
Authors: Palleschi Giovanni Maria , Torchia Daniele , Fabbri Paolo 
Published: July 2014

AbstractBlue rubber‐bleb nevus syndrome (BRBNS), or Bean's syndrome, is a rare angiomatosis characterized by multiple cavernous hemangiomas of the skin, mucosae and frequently of other sites. A 49‐year‐old male patient had been affected since birth by multiple angiomas localized in the skin, lips, oral cavity, cranial theca, and central nervous system; intrauterine rupture of angiomas in the right parietal lobe had caused partial hypotrophic paralysis of the left hemisoma. In addition to BRBNS, the patient was affected by three osteoid osteomas: this never‐described clinical association is here discussed.
Clinicopathologic Study of Cutaneous Pseudolymphomas
Authors: Lee Mi‐Woo , Lee Dong‐Kyung , Choi Jee‐Ho , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: July 2014

AbstractA study was conducted to determine the clinical and histopathologic findings of cutaneous pseudolymphomas. In the period between July of 1989 and December of 2002, 42 cases were collected. Clinical records and pathology slides of the patients were reviewed retrospectively. A striking common clinical feature was a pruritic papule, nodule, or plaque with a smooth surface on the head and neck. The histologic patterns were diverse, MF‐like, perivascular/periadnexal, nodular, diffuse, pseudolymphomatous folliculitis, and acral pseudolymphomatous angiokeratoma of children (APACHE) patterns. The most common pattern was a multinodular pattern with an extension into the deep dermis and subcutaneous adipose tissue. The differentiation between cutaneous lymphomas and pseudolymphomas must depend on a constellation of criteria, never on a single criterion.