bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scaling of respiration in colonial invertebrates
Authors: Brown Patrick D. , Walsh Elizabeth J. 
Published: July 2024

AbstractColoniality may grant colony members an energetic advantage in the form of lower individual respiration rates as colony size increases. If this occurs it should be apparent as negative allometric scaling of respiration with colony size, and colonial organisms should have scaling factors < 1. However, colonial members from phylum Rotifera have yet to be examined. To test if colonial rotifers possess allometric scaling relationships between respiration rate and colony size, we measured respiration rates for four solitary and three colonial rotifer species; from these respiration rates we estimated scaling factors. We found mixed evidence for allometric scaling of respiration rate in colonial rotifers. Both rotifers with allometric scaling of respiration rate, Conochilus hippocrepis and Lacinularia flosculosa, have extensive mucilaginous coverings. These coverings may represent an investment of colony members into a shared structure, lowering individual metabolic costs and thus respiratory needs. Additionally, we determined which traits are associated with allometric scaling of respiration. We compiled known scaling factors for animal phyla from a wide phylogenetic spectrum with colonial representatives and conducted a hierarchical mixed regression that included attributes of colonies. Traits associated with allometric scaling in colonial animals included colony shape, the presence of shared extrazooidal structures, and planktonic lifestyle. There are many other colonial rotifers and animal taxa for which allometric scaling factors have yet to be estimated, knowing these may enhance our understanding of the benefits of coloniality in animals.
Simulation‐based optimization and experimental comparison of intracranial T2‐weighted DANTE‐SPACE vessel wall imaging at 3T and 7T
Authors: de Buck Matthijs H. S. , Hess Aaron T. , Jezzard Peter 
Published: July 2024

AbstractPurposeT2‐weighted DANTE‐SPACE (Delay Alternating with Nutation for Tailored Excitation — Sampling Perfection with Application optimized Contrasts using different flip angle Evolution) sequences facilitate non‐invasive intracranial vessel wall imaging at 7T through simultaneous suppression of blood and CSF. However, the achieved vessel wall delineation depends closely on the selected sequence parameters, and little information is available about the performance of the sequence using more widely available 3T MRI. Therefore, in this paper a comprehensive DANTE‐SPACE simulation framework is used for the optimization and quantitative comparison of T2‐weighted DANTE‐SPACE at both 7T and 3T.MethodsSimulations are used to propose optimized sequence parameters at both 3T and 7T. At 7T, an additional protocol which uses a parallel transmission (pTx) shim during the DANTE preparation for improved suppression of inflowing blood is also proposed. Data at both field strengths using optimized and literature protocols are acquired and quantitatively compared in six healthy volunteers.ResultsAt 7T, more vessel wall signal can be retained while still achieving sufficient CSF suppression by using fewer DANTE pulses than described in previous implementations. The use of a pTx shim during DANTE at 7T provides a modest further improvement to the inner vessel wall delineation. At 3T, aggressive DANTE preparation is required to achieve CSF suppression, resulting in reduced vessel wall signal. As a result, the achievable vessel wall definition at 3T is around half that of 7T.ConclusionSimulation‐based optimization of DANTE parameters facilitates improved T2‐weighted DANTE‐SPACE contrasts at 7T. The improved vessel definition of T2‐weighted DANTE‐SPACE at 7T makes DANTE preparation more suitable for T2‐weighted VWI at 7T than at 3T.
Physiotherapists’ attitudes and beliefs in the management of low back pain: Protocol for a systematic review
Authors: Jayani S. , Raghava Neelapala Y. V. , Nayak Shreyas , Naik Anusha R. , Vishal Kavitha 
Published: July 2024

AbstractBackgroundLow back pain (LBP) poses a significant global health burden where a biopsychosocial model of care has been recommended. Physiotherapists (PTs) play a crucial role in LBP management; however, their attitudes and beliefs towards LBP were not reviewed in detail.ObjectiveThis systematic review aims to summarise the attitudes and beliefs of PTs towards LBP and the factors influencing them.MethodsThe review protocol and methods adhere to the PRISMA‐P and Meta Analyses and Systematic Reviews for Observational Studies in Epidemiology (MOOSE) guidelines. A comprehensive search of PubMed, Scopus, CINAHL, Web of Science, PEDro and Ovid databases will be conducted to search for cross‐sectional studies evaluating PTs' attitudes and beliefs towards LBP. Two reviewers will independently screen the articles, conduct data extraction and assess methodological quality using the Joanna Briggs Institute's critical appraisal tool for prevalence studies. Data synthesis will involve a narrative synthesis of study characteristics, attitudes, beliefs, and methodological quality. If feasible, a meta‐analysis will be performed to quantify the pooled effects.ConclusionDespite the emphasis on biopsychosocial approaches for managing LBP, the adoption of such approaches in physiotherapy practice is still suboptimal, with attitudes and beliefs of PTs being considered an important factor influencing treatment practices. Our review will summarise the literature on attitudes and beliefs of PTs towards LBP. Such knowledge would inform the need for development of additional interventions addressing the attitudes and beliefs that would eventually enhance the update of the biopsychosocial model of care in physiotherapy management of LBP.
«I can't imagine it without my nurse»: Experiences of people with chronic kidney disease in the evaluation process as kidney transplant candidates
Authors: Pedreira‐Robles Guillermo , Morín‐Fraile Victoria , Bach‐Pascual Anna , Graells‐Sans Ariadna , Garcimartín Paloma 
Published: July 2024

AbstractThis qualitative study aimed to explore the experiences of 11 adults with chronic kidney disease (CKD) undergoing evaluation for kidney transplant (KT) and examine the role played by the nurse in the process. Employing a descriptive phenomenology approach, semi‐structured interviews were conducted between October 2022 and July 2023. Thematic analysis, facilitated by Atlas. ti software, revealed a systemic management diagram with “The candidate for kidney transplant and their reality” at the center, followed by “The process of chronic kidney disease and kidney transplantation,” and concluding with the most distal category centered on “The kidney transplant access nurse.” This organizational framework provided insights into the layers of relationships between emerging themes. The findings underscored the complexity and multidimensionality of the CKD and KT process, emphasizing the nurse's pivotal role as a guide and protector throughout the evaluation process for accessing kidney transplantation. The convergence of results with existing literature highlighted the need to address challenges such as lack of time, resources, and emotional support to enhance the quality of care. Recognizing the nurse's crucial importance in this process, the study emphasizes the significance of addressing these challenges to improve patient care and calls for attention to the nurse's role in guiding individuals through the intricate journey of CKD and kidney transplantation.
The psychological burden associated with metabolic syndrome: Evidence from UK and US older adults
Authors: Robinson Eric , Daly Michael , Putra I Gusti Ngurah Edi 
Published: July 2024

AbstractIntroductionWe examined the psychological burden associated with metabolic syndrome (MetSyn).MethodsWe used comparable longitudinal data of older adults (≥50 years) from the UK (English Longitudinal Study of Aging) and the US (Health and Retirement Study). We defined MetSyn based on biomarker assessments (e.g., blood pressure, impaired glycemic control). Using regression models, we tested a range of individual psychological outcomes (e.g., depressive symptoms) associated with MetSyn. We also examined whether these psychological outcomes may explain or moderate the link between MetSyn and non‐communicable diseases (NCDs).FindingsMetSyn was associated cross‐sectionally with a range of psychological outcomes, including depression, anxiety, loneliness, hopelessness, cynical hostility, social strain, negative affect and decreased positive affect, social support and purpose in life. There was no convincing evidence that psychological factors interacted with or explained (mediated) the relationship between MetSyn and increased risk of developing NCD over 10‐year follow‐ups.ConclusionsMetSyn and the psychological burden outcomes examined may have independent effects on NCD risk.
Foaming‐structural relationship of rotational molded nanocomposite foams: Box–Behnken response surface methodology implementation
Authors: Daryadel Mahsa , Azdast Taher 
Published: July 2024

AbstractRotational molded foam is known as one of the most popular types of polymeric foams due to its unique properties. Hence, the production of rotational molded foam samples has been well‐addressed in the foam literature, and several researchers have tried to produce these samples using different approaches. However, there is no comprehensive research that investigates the structural properties of nanocomposite foam samples produced by a two‐step process of rotational molding and batch foaming. Therefore, the effect of nanoclay and foam processing parameters on the structural properties of the samples produced by this method was investigated in this study. For this purpose, the Box–Behnken design of response surface methodology was used. The results revealed that the foaming temperature was the most effective parameter on cell density and expansion ratio. Also, the foaming time was reported as the most effective parameter on the cell size. Then, the response variables were subjected to single‐ and multi‐objective optimizations. Finally, the addition of 1.2 wt% of nanoclay, the foaming temperature of 141°C, and the foaming time of 85 s were introduced as the most optimal conditions to simultaneously achieve maximum cell density and expansion ratio and minimum cell size in the rotational molded nanocomposite foam samples.
Commercial markups on pediatric oncology drugs at 340B pediatric hospitals
Authors: Liu Ian T. T. , Wang Junyi , Sarpatwari Ameet , Kesselheim Aaron S. , Feldman William B. 
Published: July 2024

AbstractEligible pediatric hospitals can purchase clinician‐administered drugs at discounted rates through the 340B Drug Pricing Program and charge payers prices exceeding drug acquisition costs, but the magnitude of these markups is not known. In a study of newly approved oncology drugs at pediatric 340B hospitals, median negotiated prices ranged from 102% (interquartile range [IQR]: 91%–156%) of average sales price (ASP) at Phoenix Children's Hospital to 630% (IQR: 526%–630%) at Driscoll Children's Hospital. Pediatric hospitals participating in the federal 340B Drug Pricing Program can extract steep payments on new drugs from commercial insurers, though with wide variation between and within hospitals.
Three‐dimensional (3D) woven flax fiber/polylactic acid (PLA) composites for high flexural strength
Authors: Wodag Awoke Fenta , Yang Chunbing , Gao Shuo , Wang Ruijie , Wang Yudong , Azizul Islam Md , Yimer Tamrat Tesfaye , Xu Fujun 
Published: July 2024

AbstractThree dimensional (3D) textiles are preferable reinforcing materials for composites with lightweight and higher mechanical properties. In this study, a 3D woven flax fiber reinforced PLA composite with better flexural and tensile properties was developed. Four hybrid yarns with varied PLA contents were prepared as warp, weft and z‐yarns to weave the 3D preform and then changed to composites through compression molding technology without additional fillers and matrixes. The composite's flexural and tensile properties were studied and an optimum value of 78.0 and 140.0 MPa respectively were found. Stress strain properties were also discussed which implies the flexural elongation is higher than those of tensile values. The microstructure was analyzed using optical microscope and SEM equipment's showed composites with higher PLA content were more brittle due to the PLA inimitable behavior. The thermal properties of the 3D composites made with different Flax/PLA combinations have closer and comparable values. One way ANOVA statistical analysis was done to show the significancy of PLA /Flax mass ratio, which has a significant effect on composite's properties. This study could bring a novel procedural approach for an advanced 3D woven composites for load bearing applications.Highlights
3D woven flax /PLA composite was developed using Flax/PLA hybrid yarns
Tensile and flexural properties were studied
Flexural strength increases with PLA, but, slightly lower in its strain
PLA/Flax mass ratio has a significant effect on composite's properties
The mechanical strengths were improved compared to the related findings
Multi‐objective optimization of hybrid polypropylene composites for enhanced mechanical, thermal, and flame‐retardant properties
Authors: Mai Nguyen Tran Thanh , Dang Xuan‐Phuong , Prabhakar M. N. , Song Jung‐il 
Published: July 2024

AbstractOptimizing composite materials is crucial for engineering advancements because it allows for the creation of materials tailored to specific functional requirements, thereby enhancing efficiency, safety, and sustainability. This study examines both the combined and individual effects of long flax fiber (LFF) bundles, short basalt fibers (BF), and rice husk powder (RHP) on the properties of polypropylene (PP) hybrid composites. LFF primarily provides mechanical strength, BF enhances mechanical, thermal, and flame‐retardant properties by filling gaps, and RHP reinforces and improves the overall composite. Contrary to previous studies that relied on random combinations, this research employs a systematic Box–Behnken design (BBD) for three variables: LFF plies, BF, and RHP by weight percentage. This approach facilitated the development of a new second‐order regression equation via response surface methodology (RSM), clarifying the contribution of each component, with R2 values exceeding 0.85, indicating high predictability. Optimization, conducted using a non‐dominated sorting genetic algorithm (NSGA‐II), demonstrated that the optimal composites significantly outperformed the non‐optimized ones in mechanical strength, thermal stability, and flame retardancy. Compared to the average values before optimization, improvements post‐optimization included increases of 49.86% in tensile strength (TS), 38.82% in TS modulus, 73.93% in char yield (YC), and 29.81% in peak heat release rate (pHRR). Specifically, the fire performance index improved by 237.5% and the fire growth index by 101.33%, compared to pure PP, highlighting significant advancements in fire safety. This study shows that mathematical equations can predict composite properties, helping to select balanced compositions without sacrificing flammability.Highlights
Multi‐filler approach technique used for manufacturing of PP composites.
LFF, BF & RHP optimize mechanics & flammability.
Box–Behnken design predicts optimal composition for superior properties.
NSGA‐II optimization improves tensile, thermal & flame retardant properties.
The effect of constitutive root isoprene emission on root phenotype and physiology under control and salt stress conditions
Authors: Bellucci Manuel , Mostofa Mohammad Golam , Weraduwage Sarathi M. , Xu Yuan , Abdelrahman Mostafa , De Gara Laura , Loreto Francesco , Sharkey Thomas D. 
Published: July 2024

AbstractIsoprene, a volatile hydrocarbon, is typically emitted from the leaves of many plant species. Given its well‐known function in plant growth and defense aboveground, we examined its effects on root physiology. We used isoprene‐emitting (IE) lines and a non‐emitting (NE) line of Arabidopsis and investigated their performance by analyzing root phenotype, hormone levels, transcriptome, and metabolite profiles under both normal and salt stress conditions. We show that IE lines emitted tiny amounts of isoprene from roots and showed an increased root/shoot ratio compared with NE line. Isoprene emission exerted a noteworthy influence on hormone profiles related to plant growth and stress response, promoting root development and salt‐stress resistance. Methyl erythritol 4‐phosphate pathway metabolites, precursors of isoprene and hormones, were higher in the roots of IE lines than in the NE line. Transcriptome data indicated that the presence of isoprene increased the expression of key genes involved in hormone metabolism/signaling. Our findings reveal that constitutive root isoprene emission sustains root growth under saline conditions by regulating and/or priming hormone biosynthesis and signaling mechanisms and expression of key genes relevant to salt stress defense.
The impact of physical therapy intervention of dysphagia on preventing pneumonia in acute stroke patients: A randomized controlled trial
Authors: Darwish Moshera , El‐Tamawy Mohammed S. , Mahmoud Aya , Ali Ahmed S. , Khalifa Heba A. 
Published: July 2024

AbstractBackground and ObjectivesDysphagia is a common complication following stroke. It corresponds to the development of pneumonia, which is always associated with bad prognosis, longer hospital stays and increased mortality. The aim of the study was to assess the impact of physical therapy intervention of dysphagia on preventing pneumonia in acute stroke patients.MethodsA single‐blind randomized controlled trial was carried out on 70 ischemic stroke patients with oropharyngeal dysphagia, age ranged from 49 to 65 years. They were randomly assigned to two groups (control and study) of equal number. Patients in the control group received oral care and nasogastric tube feeding, while patients in the study group received the same program in addition to the designed physical therapy program (exercises and neuromuscular electrical stimulation). The intervention program was applied for 40 min/session, 1 session/day, and 5 days/week for 4 weeks. Gugging swallowing screen (GUSS), and stroke associated pneumonia (SAP) control and prevention criteria were used to assess dysphagia and incidence of pneumonia at baseline, after two and 4 weeks of intervention for both groups.ResultsBefore treatment, all patients were susceptible to pneumonia after two and 4 weeks of intervention; there were a significant increase in GUSS score in both groups with more improvement in favor of the study group (p < 0.05) and a statistically significant increase in incidence of SAP after 2 weeks of intervention only in the control group (p < 0.05). The results also showed a significant negative correlation between GUSS score and SAP (r = − 0.3662, p = 0.0018)Implications for Physiotherapy Practiceadding physical therapy (exercise therapy and neuromuscular electrical stimulation) to oral care and nasogastric tube feeding is effective in improving oropharyngeal dysphagia and decreasing the incidence of aspiration pneumonia in acute ischemic stroke patients.
Exposure to golimumab during pregnancy: Results from the Company's global safety database
Authors: Otero‐Lobato Marijo , Adeyemo Adesoji , Higley Michelle , Lomax Kathleen G. , Geldhof Anja , Esslinger Suzan 
Published: July 2024

AbstractData on the use of golimumab (GLM) during pregnancy are limited. This study evaluated pregnancy outcomes in women treated with GLM during pregnancy. Cumulative data on GLM‐exposed pregnancies from the Company's global safety database (GSD) are summarized. Cases were medically confirmed maternal exposures to GLM during pregnancy or within 3 months prior to conception with a reported pregnancy outcome. Pregnancy outcomes (e.g., live births) and congenital anomalies in prospectively reported cases (i.e., pregnancy outcome not known when first reported to the company) are presented in a descriptive manner. As of May 31, 2022, 261 prospectively reported pregnancies exposed to GLM were reported in the GSD: 214 (82.0%) live births (including six sets of twins), 31 (11.9%) spontaneous abortions (including one set of twins), 13 (5.0%) induced/elective abortions, 2 (0.8%) reported intrauterine death/still birth, and 1 (0.4%) fetal adverse event in an ongoing pregnancy. The majority of pregnancies had exposure to GLM at least in the first trimester of pregnancy. In total, seven congenital anomalies (7/261; 2.7%) were reported. Of these seven congenital anomalies, five were considered major according to EUROCAT classification version 1.4. Among the five prospectively reported congenital anomalies noted in live births (5/214; 2.3%), four were classified as major (4/214; 1.8%). The rates of adverse pregnancy outcomes and major congenital anomalies in prospectively reported pregnancy cases with exposure to GLM in the Company's GSD were consistent with published background rates for the general population.
Degradation index‐based prediction for remaining useful life using multivariate sensor data
Authors: Kang Wenda , Jongbloed Geurt , Tian Yubin , Chen Piao 
Published: July 2024

AbstractThe prediction of remaining useful life (RUL) is a critical component of prognostic and health management for industrial systems. In recent decades, there has been a surge of interest in RUL prediction based on degradation data of a well‐defined degradation index (DI). However, in many real‐world applications, the DI may not be readily available and must be constructed from complex source data, rendering many existing methods inapplicable. Motivated by multivariate sensor data from industrial induction motors, this paper proposes a novel prognostic framework that develops a nonlinear DI, serving as an ensemble of representative features, and employs a similarity‐based method for RUL prediction. The proposed framework enables online prediction of RUL by dynamically updating information from the in‐service unit. Simulation studies and a case study on three‐phase industrial induction motors demonstrate that the proposed framework can effectively extract reliability information from various channels and predict RUL with high accuracy.
Effectiveness of machine learning at modeling the relationship between Hi‐C data and copy number variation
Authors: Wang Yuyang , Sun Yu , Liu Zeyu , Chen Bijia , Chen Hebing , Ren Chao , Lin Xuanwei , Hu Pengzhen , Jia Peiheng , Xu Xiang , Xu Kang , Liu Ximeng , Li Hao , Bo Xiaochen 
Published: July 2024

AbstractCopy number variation (CNV) refers to the number of copies of a specific sequence in a genome and is a type of chromatin structural variation. The development of the Hi‐C technique has empowered research on the spatial structure of chromatins by capturing interactions between DNA fragments. We utilized machine‐learning methods including the linear transformation model and graph convolutional network (GCN) to detect CNV events from Hi‐C data and reveal how CNV is related to three‐dimensional interactions between genomic fragments in terms of the one‐dimensional read count signal and features of the chromatin structure. The experimental results demonstrated a specific linear relation between the Hi‐C read count and CNV for each chromosome that can be well qualified by the linear transformation model. In addition, the GCN‐based model could accurately extract features of the spatial structure from Hi‐C data and infer the corresponding CNV across different chromosomes in a cancer cell line. We performed a series of experiments including dimension reduction, transfer learning, and Hi‐C data perturbation to comprehensively evaluate the utility and robustness of the GCN‐based model. This work can provide a benchmark for using machine learning to infer CNV from Hi‐C data and serves as a necessary foundation for deeper understanding of the relationship between Hi‐C data and CNV.