bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive investigation of predictive processing: A cross‐ and within‐cognitive domains fMRI meta‐analytic approach
Authors: Costa Cristiano , Pezzetta Rachele , Masina Fabio , Lago Sara , Gastaldon Simone , Frangi Camilla , Genon Sarah , Arcara Giorgio , Scarpazza Cristina 
Published: August 2024

AbstractPredictive processing (PP) stands as a predominant theoretical framework in neuroscience. While some efforts have been made to frame PP within a cognitive domain‐general network perspective, suggesting the existence of a “prediction network,” these studies have primarily focused on specific cognitive domains or functions. The question of whether a domain‐general predictive network that encompasses all well‐established cognitive domains exists remains unanswered. The present meta‐analysis aims to address this gap by testing the hypothesis that PP relies on a large‐scale network spanning across cognitive domains, supporting PP as a unified account toward a more integrated approach to neuroscience. The Activation Likelihood Estimation meta‐analytic approach was employed, along with Meta‐Analytic Connectivity Mapping, conjunction analysis, and behavioral decoding techniques. The analyses focused on prediction incongruency and prediction congruency, two conditions likely reflective of core phenomena of PP. Additionally, the analysis focused on a prediction phenomena‐independent dimension, regardless of prediction incongruency and congruency. These analyses were first applied to each cognitive domain considered (cognitive control, attention, motor, language, social cognition). Then, all cognitive domains were collapsed into a single, cross‐domain dimension, encompassing a total of 252 experiments. Results pertaining to prediction incongruency rely on a defined network across cognitive domains, while prediction congruency results exhibited less overall activation and slightly more variability across cognitive domains. The converging patterns of activation across prediction phenomena and cognitive domains highlight the role of several brain hubs unfolding within an organized large‐scale network (Dynamic Prediction Network), mainly encompassing bilateral insula, frontal gyri, claustrum, parietal lobules, and temporal gyri. Additionally, the crucial role played at a cross‐domain, multimodal level by the anterior insula, as evidenced by the conjunction and Meta‐Analytic Connectivity Mapping analyses, places it as the major hub of the Dynamic Prediction Network. Results support the hypothesis that PP relies on a domain‐general, large‐scale network within whose regions PP units are likely to operate, depending on the context and environmental demands. The wide array of regions within the Dynamic Prediction Network seamlessly integrate context‐ and stimulus‐dependent predictive computations, thereby contributing to the adaptive updating of the brain's models of the inner and external world.
Morbidity of multimodal treatments including endoscopic surgery for sinonasal malignancies: Results of an international collaborative study on 940 patients (MUSES)
Authors: Bertazzoni Giacomo , Vinciguerra Alessandro , Camous Domitille , Ferrari Marco , Mattavelli Davide , Turri‐Zanoni Mario , Schreiber Alberto , Taboni Stefano , Rampinelli Vittorio , Arosio Alberto Daniele , Verillaud Benjamin , Piazza Cesare , Battaglia Paolo , Bignami Maurizio , Deganello Alberto , Castelnuovo Paolo , Nicolai Piero , Herman Philippe 
Published: August 2024

AbstractIntroductionIn the management of sinonasal malignancies treatment‐induced morbidity and mortality is gaining relevance both for surgical approaches (endoscopic and open resection) and non‐surgical therapies. The aim of this multicenter study is to assess complications associated with endoscopic surgery and non‐surgical treatments (neoadjuvant and/or adjuvant) for malignant sinonasal tumors.MethodsAll patients with nasoethmoidal malignancies treated with curative intent with endoscopic or endoscopic‐assisted surgery at three referral centers with uniform management policies were included. Neo‐ and/or adjuvant (chemo)radiotherapy was administered according to histology and pathological report. Demographics, treatment characteristics, and complications related both to the surgical and non‐surgical approaches were retrieved. The data were analyzed with univariate and multivariate statistics to assess independent predictors of complications.ResultsNine hundred and forty patients were included, 643 males (68%) and 297 females (32%). A total of 225 complications were identified in 187 patients (19.9%): cerebrospinal fluid (CSF) leak (3.5%), mucocele (2.3%), surgical site bleeding (2.0%), epiphora (2.0%), and radionecrosis (2.0%) were the most common. Treatment‐related mortality was 0.4%. Variables independently associated with complications at multivariate analysis were principally dural resection (OR 1.92), cranioendoscopic or multiportal resection (OR 2.93), dural repair with multilayer technique with less than three layers (OR 2.17), and graft different from iliotibial tract (OR 3.29).ConclusionOur study shows that modern endoscopic treatments and radiotherapy for sinonasal malignancies are associated with limited morbidity and treatment‐related mortality. CSF leak and radionecrosis, although rare, remain the most frequent complications and should be further addressed by future research efforts.
Explicating System Value through First Principles: Re‐Uniting Decision Analysis with Systems Engineering
Authors: Peterson Troy , Schindel Bill 
Published: August 2024

ABSTRACTSystem complexity continues to grow, creating many new challenges for engineers and decision makers. To maximize value delivery, “both” systems engineering and decision analysis are essential. The systems engineering profession has had a significant focus on improving systems engineering processes. While process plays an important role, the focus on process was often at the expense of foundational engineering axioms and their contribution to system value. As a consequence, systems engineers were viewed as process developers and managers versus technical leaders with a deep understanding of how system interactions are linked to stakeholder value. With the recent shift toward model‐based systems engineering (MBSE), systems engineering is “getting back to basics,” focusing on value delivery via first principles, using established laws of engineering and science. This paper describes how pattern‐based systems engineering (PBSE), as outlined within INCOSE's model‐based systems engineering (MBSE) initiative, explicates system value through modeling of first principles, re‐uniting systems engineering and decision analysis capabilities.
Studies in Solanum L. (and related genera) 3. A provisional conspectus of the genus Cyphomandra Mart. ex Sendtner
Authors: Child Alan 
Published: August 2024

SummaryAn attempt is made to formulate a taxonomic revision of the poorly known neotropical genus Cyphomandra Mart. ex Sendt.Taxa of sectional rank are proposed and described. Species ore attributed to these infra‐generic groups. The type section Cyphomandra is considered as fairly recently speciated and requires future evaluation at subsectional or serial rank.The following are the sections proposed:

Cyphomandra. Lectotype species: C. betacea (Cav.) Sendt.
Ceratostemon Miers sensu stricto Child. Lectotype species: C. floribunda (Miers) Dun.
Allophylla Child sect. nov. Type species: C. allophylla (Miers) Hemsley.
Rhyncantherum Bitter pro sect. generis Solani. Monotypic: C. fraxinella Sendt.
Cornigera Child sect. nov. Type species: C. cornigera Dunal.
Cyphomandropsis Bitter pro sect. generis Solani. Lectotype species: C. stuckertii (Bitt.) D'Arcy.
A sectional determination key is provided.Species of uncertain position and species to be excluded from the genus are appended.
Notes on vegetation and soil in Bale Province of Ethiopia
Authors: Weinert E. , Mazurek A. 
Published: August 2024

SummaryThe altitudinal vegetation zones in Bale Mountains are discussed in connection with their soil conditions. The soils of the different vegetation units have a more or less uniform character; they are rich in basic cations, organic matter and plant accessible nutrients. There might bo one reason for the relative uniformity, this is the parent rock material which is mainly basalt of the Tertiary Trappean Lava Formation.
Evaluation of a Diazo‐Based Point‐Of‐Care Bilirubin Assay careSTART S1 Total Bilirubin Strip
Authors: Kwoun Woojae , Lee Jeong Joong , Youn Young‐Ah , Chae Hyojin , Lee Jehoon 
Published: August 2024

ABSTRACTBackgroundNeonatal jaundice (NNJ) affects a significant proportion of newborns globally, with an increased burden in low‐resource settings. Effective health risk management of NNJ is hindered, particularly in resource‐constrained environments, where early detection and treatment are challenging. The careSTART S1 Total Bilirubin Strip, a point‐of‐care testing (POCT) device based on a diazo‐method, offers a potential solution by enabling onsite bilirubin measurement, thus, addressing the gap in early NNJ detection and management.MethodsThe current study evaluated the analytical performance of the careSTART S1 Total Bilirubin Strip for precision, linearity, method comparison, and lot‐to‐lot consistency following CLSI guidelines. For method comparison, 105 residual EDTA whole blood samples were analyzed with the careSTART S1 Total Bilirubin Strip and compared with reference measurements from the Roche Cobas c702 analyzer. Additionally, statistical analyses, including Passing‐Bablok regression and Bland–Altman plots, were performed.ResultsThe careSTART S1 Total Bilirubin Strip showed allowable (<10%) within‐laboratory imprecision of 2.5%–3.6% across all levels and demonstrated linearity over the range of 4.16–439.3 μmol/L. Method comparison revealed a constant negative bias with a mean bias −4.19 μmol/L. However, the 95% confidence interval (−7.10 to −1.28 μmol/L) of the bias is covered by the prespecified allowable bias of 8.3%, at medical decision point. Lot‐to‐lot variation ranged from 0.14%–6.49%, and was within the acceptable critical difference of 8.3%.ConclusionThe careSTART S1 Total Bilirubin Strip provided accurate and reliable bilirubin measurements that could contribute to neonatal care in settings lacking central laboratory facilities.
Phenotypes of autism spectrum disorder and schizoaffective disorder associated with SETD1B gene but without intellectual disability and seizures
Authors: Ünsel‐Bolat Gül , Bolat Hilmi 
Published: August 2024

AbstractThe SETD1B gene, located on chromosome 12q24, is one of the chromatin‐modifying genes involved in epigenetic regulation of gene transcription. The phenotype of pathogenic variants in the SETD1B gene includes intellectual disability, seizures, and language delay (IDDSELD, OMIM 619000). In this study, we present a family consisting of consanguineous parents who died of cancer and their offspring. This family includes two cases diagnosed with autism spectrum disorder (ASD); six cases diagnosed with schizophrenia, bipolar disorder, or schizoaffective disorder; there cases diagnosed with cancer; and five cases who died of unknown causes in early childhood. Three affected members of this family agreed to genetic testing. We used whole exome sequencing. We report a novel in‐frame deletion variant of the SETD1B gene in a family with cases diagnosed with schizoaffective disorder and ASD without seizures and intellectual disability. It was found that the phenotypic features were inherited for at least three generations in the family we presented, and it was shown that the pathogenic variant of the SETD1B gene was transmitted from the affected parent to his affected children. In addition, the father was diagnosed with both schizoaffective disorder and leukemia. We proposed an association between rare variants of SETD1B and phenotypes of ASD and schizoaffective disorder without seizures and intellectual disability. The SETD1B gene is included in both the ASD genetic database of SFARI (https://gene.sfari.org/) and the cancer database of COSMIC (https://cancer.sanger.ac.uk/cosmic). However, there are very few reports of SETD1B gene variants as clinical entities. To our knowledge, the SETD1B gene variant has not been previously reported in an individual diagnosed with both a neuropsychiatric disorder and cancer.
Paradoxical safety leadership: Conceptualization and measurement
Authors: Hu Xiaowen , Jiang Lixin , Willis Sara , Casey Tristan , Wu Chia‐Huei 
Published: August 2024

SummaryManaging workplace safety requires leaders to navigate through competing goals and processes. However, the current conceptualization and measurement of safety leadership do not adequately address this practical reality. To address this issue, we integrate paradox theory and paradoxical leadership research with safety‐management literature to develop the conceptualization and measurement of paradoxical safety leadership (PSL). We define PSL as a multidimensional construct that consists of seemingly contradictory yet interrelated leader behaviors to meet competing goals and demands in safety management. Using a combination of deductive and inductive methods, we identify four behavioral dimensions of PSL: (1) placing an emphasis on both production and safety; (2) enforcing safety compliance while allowing flexibility; (3) bridging upper management safety requirements versus frontline safety needs and requests; and (4) balancing time in the office and the time spent with employees in the field. We then provide evidence that supports the proposed four‐factor structure, reliability, convergent, discriminant, incremental validity, and cross‐cultural invariance of the PSL scale. Our study broadens the understanding of the role of leadership in workplace safety by developing a paradoxical approach to managing safety tensions and providing a measure that has the potential to advance research in both safety and paradox leadership domains.
Effect of electron beam irradiation on glycosylation reaction and structural characterization of whey isolate protein
Authors: Zhang Linlu , Bai Rong , Jiang Shengqi , Li Ziwei , Chen Ya , Ye Xiang , Yu Jiangtao , Ding Wu 
Published: August 2024

AbstractBACKGROUNDWhey protein isolate (WPI) is a high‐quality animal protein resource. The modification of WPI through physical, chemical and biological methods can substantially improve the functional properties of proteins. This study investigated the effect of electron beam irradiation (EBI) on the modification of WPI–xylose glycosylation.RESULTSThe degree of grafting and browning revealed that EBI promoted WPI glycosylation. The maximum emission wavelength of intrinsic fluorescence was red‐shifted and the fluorescence intensity was reduced, suggesting that irradiation induced the unfolding of the WPI structure, thereby promoting glycosylation. Fourier‐transformed infrared spectroscopy revealed that the covalent binding of the conjugates occurred on the introduction of the hydrophilic groups, resulting in decreased surface hydrophobicity. When compared with conventional wet‐heat glycosylation, irradiation‐assisted glycosylation improved the emulsifying activity of WPI from 179.76 ± 0.83 to 277.83 ± 1.44 m2 g−1, and the emulsifying and rheological properties improved.CONCLUSIONThese results confirmed that EBI can increase the degree of WPI glycosylation and improve the functional properties of proteins, thereby laying a theoretical foundation for the further application of WPI. © 2024 Society of Chemical Industry.
Effect of Ca2+ signal on the activity of key enzymes of carbon metabolism and related gene expression in yeast under high sugar fermentation
Authors: Xie Dongdong , Zheng Jiaxin , Sun Yingqi , Li Xing , Ren Shuncheng 
Published: August 2024

AbstractBACKGROUNDSaccharomyces cerevisiae is a fungus widely used in the food industry and biofuel industry, whereas it is usually exposed to high sugar stress during the fermentation process. Ca2+ is a key second messenger of the cell, it can regulate cell metabolism. The present study investigated the effect of the Ca2+ signal on the activity of key enzymes of carbon metabolism and related gene expression in yeast under high sugar fermentation.RESULTSThe expression of genes encoding hexokinase was up‐regulated in the high sugar environment, the activity of hexokinase was increased, glucose transmembrane transport capacity was enhanced, the ability of glucose to enter into glycolytic metabolism was increased, and the expression of genes related to pentose phosphate metabolism, glycerol metabolism and trehalose metabolism was up‐regulated in the high glucose with Ca2+ group.CONCLUSIONCa2+ signal regulates the cellular metabolism of glycerol and trehalose and optimizes the allocation of carbon flow by regulating the key enzymes and related gene expression to enhance the resistance of yeast to high sugar stress. © 2024 Society of Chemical Industry.
Elevated levels of branched chain fatty acids in low‐salt fish sauce by co‐fermentation: flavor improvement and metabolism analysis
Authors: Zhou Yue , Wu Junxiao , Monto Abdul Razak , Yuan Li , Gao Ruichang 
Published: August 2024

AbstractBACKGROUNDTraditional fish sauce products rely on relatively long fermentation time and high salt concentration, resulting in inconsistent quality and health risks. Branched‐chain fatty acids (BCFAs) are associated with nutritional benefits and health‐care effects, mainly derived from food fermentation. This study aimed to screen BCFAs‐producing bacteria with high protease and aminotransferase activity as starter cultures for fish sauce fermentation.RESULTSThe low‐salt fish sauce products were obtained by co‐fermentation with three chosen strains. Trichloroacetic acid (TCA)‐soluble peptides and amino acid nitrogen concentrations were higher in the co‐fermentation group (FH group). The organoleptic evaluation showed co‐fermentation optimized flavor composition and endured with rich taste. The levels of BCFAs and branched‐chain amino acids (BCAAs) significantly increased by co‐fermentation. Volatile metabolomics analysis indicated that BCFAs, branched‐chain esters, and pyrazines were the key flavor compounds in the co‐fermented group.CONCLUSIONThe co‐fermentation system with selected strains to ferment low‐salt fish sauce has the potential to increase BCFA content and improve flavor and nutrition. © 2024 Society of Chemical Industry.
Wine metabolome and sensory analyses demonstrate the oenological potential of novel grapevine genotypes for sustainable viticulture in warm climates
Authors: Gómez Héctor Alonzo Gómez , Niederauer Guilherme Francio , Minatel Igor Otavio , Antunes Elisa Ribeiro Miranda , Carneiro Mara Junqueira , Sawaya Alexandra Christine Helena Frankland , Zanus Mauro Celso , Ritschel Patrícia Silva , Quecini Vera , Pereira Lima Giuseppina Pace , Marques Marcia Ortiz Mayo 
Published: August 2024

AbstractBACKGROUNDGenetic breeding is essential to develop grapevine genotypes adapted to warm climates and resistant to pathogens. Traditionally cultivated Vitis vinifera is susceptible to biotic and abiotic stresses. Winemakers and consumers, however, perceive wines from non‐vinifera or hybrid cultivars as inferior. In this study, sensory analyses and comprehensive metabolite profiling by targeted and untargeted approaches were used to investigate the oenological potential of wines from grapes of genotypes developed throughout four breeding cycles to improve climate adaptation, sugar contents and berry color.RESULTSNovel genotypes had higher yields and the wines exhibited increased contents of polyphenols, including anthocyanins. Volatile monoterpenes in the wines decreased throughout breeding cycles in the absence of selective pressure. Polyphenol contents were higher in intermediate wines, with hydroxytyrosol contents reaching up to three times reported values. Mouthfeel attributes astringency, leafy taste, flavor and body, and persistency showed significant correlation with untargeted features. Supervised model‐based analyses of the metabolome effectively discriminate wines from distinct genetic origins.CONCLUSIONTaken together, the results demonstrate the potential of novel grapevine genotypes to a more sustainable viticulture and quality wine production in warm climates. Comprehensive metabolite profiling of the wines reveals that genotype clustering is dependent on the chemical class and that traits not submitted to selective pressure are also altered by breeding. Supervised multivariate models were effective to predict the genetic origin of the wines based on the metabolic profile, indicating the potential of the technique to identify biomarkers for wines from sustainable genotypes. © 2024 Society of Chemical Industry.
Age and Menopausal Status in Idiopathic Subglottic Stenosis
Authors: Awadallah Andrew S. , Bowen Andrew J. , Ali Hawa M. , O'Byrne Thomas J. , Aden Aisha A. , Khalil Yousuf H. , Edell Eric S. , Koster Matthew J. , Bayan Semirra L. , Ekbom Dale C. 
Published: August 2024

ObjectiveTo evaluate the impact of age on disease recurrence in idiopathic subglottic stenosis (iSGS) patients.MethodsThis was a retrospective chart review of iSGS patients treated with laser wedge excision. Patients did not have prior surgery. Survival rates free of recurrence were estimated using the Kaplan–Meier methods, and associations were evaluated using Cox Proportional Hazards models.ResultsEighty‐five female patients were included in the study. Most patients (68%) were postmenopausal, had first period at or before 13 years of age, had at least one full‐term pregnancy (82%), were not undergoing hormone replacement therapy (93%), were not using hormonal birth control (88%), and were either partially or completely compliant with triple therapy regime (80%). There was a statistically significant average reduction in risk of recurrence of 5% for every additional year of age (p < 0.0001). When compared to patients older than 65 years of age, patients less than 35 were nearly 10 times more likely to recur (p = 0.002), and patients 55–65 and 45–55 years of age were 8 and 5 times more likely to recur, respectively (p = 0.003 and 0.009). Additionally, females on birth control showed decreased risk of recurrence of 74% compared with their counterparts (p = 0.04).ConclusionThis is the first study to demonstrate an inverse relationship between age and disease recurrence in patients with iSGS following surgery. Using age as a surrogate for menopausal status, these results suggest that increased age and/or birth control provide a protective effect through decreased recurrence rates, possibly mediated by decreased estrogen levels.Level of Evidence4 Laryngoscope, 2024
Economic insecurity decreases cute product choice preference via other‐focused concern and the need to connect with others
Authors: Qin Yao , Wang Xuehua 
Published: August 2024

AbstractThere are plenty of cute products in the marketplace even in difficult times. Yet, cute products do not always capture people's attention. Does insecure economic perception affect people's choice of cute products? To address this unexamined research gap, we propose that economic insecurity negatively influences cute product choice preference via the serial mediation effects of other‐focused concern and the need to connect with others. Desire for emotional support is proposed to moderate the focal relationship. We demonstrate these effects using four studies. Studies 1a and 1b tested the causal relationship between primed economic insecurity and choice preference towards cute products as well as ruling out several possible mechanisms (i.e., sense of control, affect, parental caring motives, risk aversion, the desire for cuteness, and the need for protection). Study 2 demonstrated that other‐focused concern and the need to connect with others serially mediated the above effect. Study 3 explored the moderating effect of desire for emotional support. Companies that manufacture cute products can benefit from our findings on how to communicate with consumers in times of economic downturn.