bluuebunny/crossref_metadata_2025_split huggingface dataset:
811 – Long-term Safety and Efficacy of Atomoxetine in Adult Adhd Japanese Patients
Authors: Hirata Y. , Goto T. , Takita Y. , Trazepacz P.T. , Allen A.J. , Ichikawa H. , Takahashi N. 
Published: July 2013

Introduction:Research has shown that ADHD symptoms and functional impairment often persist beyond childhood into adulthood. Thus an effective therapy that can be tolerated over long-term use in adults is needed. This is the first long term safety and tolerability study of an adult ADHD medication in Asia.Objectives:Assess long-term safety, tolerability, and efficacy of atomoxetine (ATX) in adult Japanese ADHD patients.Aims:Demonstrate the safety and tolerability of long-term ATX.Methods:ATX (40-120 mg/day) was evaluated based on integrated analyses of a 10 week double-blind (DB) study and a 48 week open-label long term (LT) extension study. Long-term safety and tolerability were assessed by adverse events, discontinuation rate, and vital-signs. Efficacy measures included change from baseline in Conners’ Adult ADHD Rating Scale- Investigator Rated (CAARS-Inv:SV) total symptoms score, behavior Rating Inventory of Executive Function (BRIEF-A), and Adult ADHD/QoL Measure (AAQoL).Results:233 patients took ATX (LT mean final prescribed dose: 108.3 mg/day). AEs leading to discontinuations were seen in 37 (15.9%) patients, the most common being nausea in 10 (4.3%) patients. Statistically significant baseline-to-endpoint reductions in mean CAARS-Inv:SV total symptoms score during in the DB study continued throughout the LT study. Similar reductions were seen in BRIEF-A Self Report scores. These findings along with AAQoL results indicated that patients perceived improvements in both QoL and Executive Function.Conclusions:Long-term ATX treatment was shown to be generally safe and tolerable in Japanese adult ADHD patients. Results also suggested ATX improved ADHD core symptoms, QoL and Executive Functions.
813 – Somatization as Central Manifestation of Depression in Iranian Culture
Authors: Firoozabadi A. , Bahredar M.J. , Seifsafari S. 
Published: July 2013

Introduction:In some cultures, including ours, direct explanation of inner psychic world is inhibited and stigmatized, therefore finding alternative modes of expression.Aims and objectives:The aim of this cross-sectional study was to reach to an estimation of the frequency of somatization in the depressed patients.Method:500 patients with major depressive disorder referred to the outpatient clinic of Shiraz University of Medical Sciences were recruited and diagnosed based on DSM-IV-TR. Through psychiatric interview, we assessed the presenting complaints of these patients. the presenting symptoms were divided into three main categories namely: mental symptoms, pain, and physical symptoms other than pain. Statistical analysis (chi-square and logistic regression) were performed to assess the relationship between presenting symptoms and some demographic variables such as age, gender, marital status, educational level and cultural background.Results:Physical symptoms other than pain in 193 (38.6%), mental symptoms in 186 (37.2%) and pain in 121 (24.2%) of the patients were seen. Pain and physical complaints were more common in patients with rural cultural background, lower education, women and the married ones. Headache (15.2%), irritability (10.6%) and pain in other areas of the body (10.4%) were the most frequent chief complaints the patients had stated. the symptoms of hypochondriasis, suicidal idea, crying, irritability and insomnia were significantly associated with the complaint of somatization.Conclusion:Somatic symptoms, especially pain, have a significant weight in the chief complaints of depressed patients. Physicians need to pay proper attention to this important issue in order to better understand their patients.
815 – Mental Health and Psychiatric Disorders in Schools
Authors: Teixeira J. , Costa A.C. , Silva A.R. , Ávila I. , Lopes R. , Mateus S. , Mota T. , Fernandes J.C. 
Published: July 2013

Introduction:The prevalence of psychiatric disorders in the general population in Portugal is estimated to be 30%. It is already known that many patients who present a psychiatric disorder do not seek a medical doctor, in part because they do not recognise their illness but also because of stigma associated to these disorders. Mental health promotion programs for schools are believed to help overcome these difficulties.Objectives:To analyse the knowledge on mental health issues and psychiatric disorders of Portuguese school students from the 7th to the 12th grade, and to assess their contact and interactions with patients who have a psychiatric disorder.Methods:Five students from each class at Pedro Alexandrino high school were selected and they were asked to answer to a questionnaire. Data collected from the questionnaires was then statistically analysed.Results:The sample collected for this study included a total of 145 students, 60% male and 40% female, with a mean age of 15years-old. Global knowledge about mental health and psychiatric disorders among students was poor and it was primarily acquired through the media. A comparatively high percentage of students in our sample (46%) knew at least one patient with a psychiatric disorder, and in most cases those patients were from their family group or circle of friends.Conclusions:Education on mental health and psychiatric disorders should be implemented at schools and within the context of health education, in order to promote mental health and also to help reduce stigma usually associated to psychiatric disorders.
835 – Prediction of Outcome in Complex Treatment Program for Pharmacoresistant Panic Disorder Patients
Authors: Kamaradova D. , Prasko J. , Cerna M. , Grambal A. , Jelenova D. , Latalova K. , Sigmundova Z. 
Published: July 2013

Causes of pharmacoresistance or resistance to cognitive behavioral therapy in patients with panic disorder have not been yet explained. Therapeutic response during antidepressants treatment is worsened by high severity of symptoms, comorbidity of agoraphobia, other anxiety disorders, depression and personality disorders, high level of dissociative symptoms, unemployment and long duration of the disorder.Method:The aim of the study was to assess the efficacy of the in-patients therapeutic program for in patients suffering with pharmacoresistant panic disorder. the therapy was conducted in a group setting and systematic CBT steps were adapted to each individual patient in the group. Pharmacological treatment underwent no or minimal changes during the trial period. Outcome measures included the Clinical Global Impressions-Severity of Illness scale (CGI-S), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Dissociative Experience Scale (DES). the primary outcome measure for treatment response was a rating of 25% improvement in BAI. A remission was defined by CGI-S scores 1 or 2.Results:67 patients with pharmacoresistance panic disorder entering into the study. Five patients drop out. 62 patients were treated with inpatients therapeutic program consisting from intensive CBT and pharmacotherapy. All patients finished 6 weeks of CBT and showed statistically significant improvement on BAI, BDI and CGI-S scales. the main predictors of achieving the response or remission were scores less than 20 in BDI, droping more than 5 point during the first week of treatment in BAI, not been married and low level of dissociation.Supported by:IGA MZ CR NT 11047-4/2010
836 – “kreis-irrenanstalt Erlangen” Germany's Unique Panoptical Asylum - An Appreciation of the First Bavarian Mental Home
Authors: Braun B. , Kornhuber J. 
Published: July 2013

Introduction:There are two edifices left to represent one of the most impressive cultural monuments of mental homes in Middle-Europe. the destruction of these historical buildings is intended to establish a modern “Translational Research Centre”.Objectives:To outline the significance of the asylum in the history of psychiatric architecture.Aims:To appreciate the first Bavarian mental home.Methods:Study of literature.Results:The British philosopher Jeremy Bentham is considered to be the founder of the panoptical (“invisible from all around”) concept in architecture. Several panoptical asylums have been built in Great Britain. in France, Italy and Germany a unique exemplar was realized. as the entire ward could be checked from a central room, the possibility of optimal surveillance of the patients was given and the minimisation of staff was enabled. in contrast to the emergent industrial cities (e.g. Nürnberg, Fürth, Schwabach) Erlangen disposed of enough building ground. There, J.M. Leupold (1794-1874) gave a lecture on the new establishing medical department of psychiatry. Thanks to his advice the project of the first Bavarian mental home could be completed within 12 years. the cruciform floor plan was supplemented by cross buildings, which constituted a relevant modification of the panoptical system. Concerning the extension of buildings (1874-1879) the internationally appreciated “system of pavillons” was realized and could be used by university since 1903.Conclusions:As the TRC-project may serve as a document for future medical progress, it is important to remember the “Kreis-Irrenanstalt Erlangen” as a milestone in the evolution of psychiatric architecture.
838 – Level of Dissociation in Patients with Bipolar Affective Disorder Compared with Healthy Controls
Authors: Latalova K. , Prasko J. , Diveky T. , Cerna M. , Grambal A. , Jelenova D. , Kamaradova D. , Mainerova B. , Vrbova K. 
Published: July 2013

According to recent findings, certain clinical symptoms of the patients suffering from affective and anxiety disorder can be related to dissociation. the aim of our study is to examine if the level of dissociation in bipolar affective disorder differ from the level of dissociation in healthy volunteers.Methods:41 patients suffering from bipolar disorder and 198 healthy controls were included in the study. Only patients in remission of the disorder, evaluated as 1 or 2 points of clinical global impression - severity scale, were included into the study. Patients were psychiatrically assessed and the state of the disorder was evaluated by experienced psychiatrist. All participants were assessed with the Dissociative Experiences Scale (DES).Results:The groups didn’t differ in demographic variables like age, gender and education. Patients had significantly higher mean score on the DES and pathological DES than healthy controls.Conclusion:Our results suggest that the level of psychological dissociation in bipolar affective patients is higher than in healthy controls.Supported by:Grant IGA MZ ČR NT11047
841 – Comparison Of Quality Of Life Between Patients With Bipolar Afective Disorder, Schizophrenia And Healthy Controls
Authors: Latalova K. , Prasko J. , Diveky T. , Kamaradova D. , Velartova H. , Grambal A. , Cerna M. , Ociskova M. , Mainerova B. , Vrbova K. 
Published: July 2013

Host of studies have now examined QoL in patients with major depressive disorder and schizophrenia until recently few had specifically focused upon QoL in patients with bipolar disorder. The purpose of the present study was to find out the QoL data in patients suffering from bipolar disorder in clinical remission and examine the extent of the effects of the demographical and clinical data on QoL in these patients. The second aim was to compare the QoL data with the data of patients suffering from schizophrenia in clinical remission and with healthy controls.Data were obtained by using the quality of life questionnaire (Quality of Life Enjoyment and Satisfaction - Q-LES-Q) for 41 bipolar patients in clinical remission. The data of these subjects were compared with the data of 40 schizophrenic patients in clinical remission and with 40 healthy controls.There are statistically significant difference in comparison with schizophrenic patients, but not in comparison with healthy controls. There were higher mean scores in most Q-LES-Q summary scales in patients with bipolar disorder in comparison with schizophrenic patients and in some summary scales in comparison with healthy controls.Our results suggest the same or higher subjective quality of life in patients suffering with bipolar disorder in clinical remission in comparison with healthy controls and higher subjective quality of life in bipolar patients in clinical remission in comparison with schizophrenic patients in clinical remission.Supported by: Grant IGA MZ ČR NT11047
842 – Euthymic Bipolar Affective Disorder Patients And Their Heart Rate Variability
Authors: Latalova K. , Prasko J. , Diveky T. , Kamaradova D. , Grambal A. , Jelenova D. , Mainerova B. , Cerna M. , Ociskova M. , Velartova H. , Vrbova K. 
Published: July 2013

BackgroundAutonomic nervous system (ANS) dysfunction and reduced heart rate variability (HRV) have been reported in a wide variety of psychiatric disorders, but have not been well characterized in bipolar patiens in remission. We recorded cardiac activity and assessed HRV in bipolar outpatients in remission.AimsAscertain if ANS decrease with the age of the patient; ascertain relation between activity of ANS and level of dissociation, and other components (age of patients, and age of disorder, dosage of psychotropic medication).MethodsAutonomic nervous system (ANS) has been evaluated during orthostatic change in three positions (1- lie down 5 minutes, 2 - stand up 5 minutes, 3 - lie down 5 minutes). The functioning of the ANS has been measured by the diagnostic systems that are using the power spectral analysis which quantifies the heart rate variability (HRV) was assessed using time domain, frequency domain, and nonlinear analyses in 23 bipolar patients in remission.ResultsWe found highly statistically significant negative correlations between level of dissociation measured by DES and most of parameters of ANS. We found negative correlations between the age of the patient and activity of ANS, and negative correlations between activity of ANS and duration and onset of disorder.ConclusionsAutonomic dysregulation is associated with bipolar disorder in remission and has relation to level of dissociation and probably to age of patiens and age of onset and duration of disorder.Supported by: Grant IGA MZ CR NT11474
844 – Therapeutic Response To Intensive Psychotherapeutic Programs In Patients With Anxiety Disorders
Authors: Prasko J. , Sigmundova Z. , Grambal A. , Kamaradova D. , Jelenova D. , Sandoval A. , Latalova K. , Vrbova K. , Cerna M. , Ociskova M. , Sedlackova Z. 
Published: July 2013

Both pharmacological and psychoterapeutical approaches have proven effectiveness for anxiety disorders. The aim of study was to establish the efficacy of CBT or short psychodynamic psychotherapy on non-selected and medication-resistant patients with anxiety disorders and to search for predictors of response.MethodShort psychodynamic psychotherapy or systematic CBT was tailored according the needs of each patient. Pharmacology treatment remained mainly unchanged during the trial period. Outcome measures were: CGI, Dissociative Experience Scale (DES), Somatoform Dissociation Questionnaire (SDQ-20), BDI, BAI. The primary outcome measures were clinical response defined as 30% decrease in BAI and remission defined as a 1 or 2 points in CGI.Results190 patients were included into the study and 15 dropped out. Altogether 175 patients completed at least 5 of 6 weeks of intensive psychotherapy program. Patients of all diagnostic groups showed significant improvement in CGI, BAI, BDI. At the end of the treatment 51.1% of the patients achieved clinical response and 42.3% clinical remission. The main characteristics present at the beginning of the trial increasing probability of achieving response or remission during the treatment were BAI score lower than 25, BDI score lower than 20, no comorbidity with personality disorder, no comorbid depression, no being divorced or widowed.ConclusionTherapeutic efficacy of the intensive psychotherapeutics programs for anxiety disorders was predicted with level of anxiety and depression, comorbidity with depression and personality disorders and marital status.Supported by: IGA MZ CR NT 11047
854 – A Logistic Regression Model For Global Functioning In Psychosis
Authors: Muñoz Negro J. , Ibáñez Casas I. , Cervilla Ballesteros J.A. 
Published: July 2013

IntroductionIn order to improve global functioning in psychotic patients is necessary to know the kind of variables influencing those.AimTo research that of a clinical and epidemiological variables group which of them are associated to a better outcome in global functioning in patients affected by psychosis.MethodsA total of 73 psychotic patients were included in this study. All of them were evaluated through a battery of tests including GAF and SIX, PANSS, S-GPTS and a comprehensive questionnaire for clinical and epidemiological variables. A binary logistic regression analysis was applied to the data set of global functioning scores divided by the median in two halves: better and worse global functioning. The model included the following variables: positive, negative and general psychopatology PANSS subscales, PANSS subtype, first or second generation antipsychotic, stimulants drugs use, tobacco use, sex, age, onset age, number of psychotic episodes and S-GPTS score.ResultsTreatment with second generation antipsychotics and lesser scoring in S-GPTS scale were associated with a better outcomes in global functioning. We found an association between lesser negative symptoms and lesser number of psychotic episodes with a better functioning which showed a marginal statistical significance.ConclusionsWe raise the question about preferential use of second generation of antipsychotics as opposed to older antipsychotics and the necessity of improving adherence to treatment for breaking the vicious cycle between psychotic episodes and a worse global functioning. Further studies with greater sample are needed to explain these and another questions.
855 – Cognitive Deficits In Patients With Schizophrenia And Comorbid Obsessivecompulsive Symptoms: a 12 Month Longitudinal Study
Authors: Schirmbeck F. , Rausch F. , Englisch S. , Eifler S. , Esslinger C. , Meyer-Lindenberg A. , Zink M. 
Published: July 2013

BackgroundEpidemiological studies estimated that amongst patients with schizophrenia a large subgroup of up to 25% also suffers from comorbid obsessive compulsive symptoms (OCS). The association between these comorbid OCS and neuropsychological impairment remains unclear and somewhat contradictory. Longitudinal approaches which investigate the stability of OCS related cognitive deficits are missing.Methods37 patients with schizophrenia and comorbid OCS and 43 schizophrenia patients without OCS were assessed with a comprehensive cognitive test-battery and compared at baseline and again 12 months later.ResultsSchizophrenia patients with comorbid OCS showed significant pronounced deficits with increasing effect sizes over the 12 month assessment period in specific cognitive areas such as visuo-spatial perception and visual memory (WAIS-R block design, Rey-Osterrieth Complex Figure Test), executive functioning (perseveration in the Wisconsin card sorting test) and cognitive flexibility (Trail making test B). These cognitive domains correlated with OCS severity and are known to be candidate domains in obsessive compulsive disorder (OCD).ConclusionsOCS in schizophrenia is associated longitudinally stable specific cognitive deficits. Prospective studies involving patients with at risk mental states for psychosis are necessary to decipher the interaction of cognitive impairment and the clinical manifestation of schizophrenia and OCS. This might facilitate the definition of patients at high risk for OCS, an early detection of subclinical levels, therapeutic interventions and clinical monitoring.
858 – Infrastructure, Training And Funding Of Mental Health Research In Europe: First Results From The Roamer Project
Authors: Leboyer M. , Brunn M. , Demotes J. , Hazo J.-B. , Obradors Tarragó C. , Papp S. , Chevreul K. ,   The ROAMER Consortium
Published: July 2013

Despite the growing burden of mental disorders and the proven impact of research, there is a scarcity of research in mental health in Europe.In the context of the ROAMER project, intending to develop a roadmap for mental health research in Europe, we aim at mapping available resources in terms of research infrastructure, training and funding so as to identify gaps and formulate recommendations.Our method was twofold. First, as part of a larger survey a consultation survey was circulated within a pilot sample of 111 European mental health researchers. Second, survey results were discussed and complemented with a focus-group-type panel, composed of national and European experts.Based on 55 survey responses and the expert panel, we have identified several key themes in the expert’s opinions. In terms of infrastructure, these include claims about a lack of collaboration and insufficient access to potentially shared resources; poor linkage between research and clinical practice; inadequate dialogue between research and policy-makers; and a lack of interdisciplinarity. In terms of training and capacity building, it emerged that incentives lack to attract and keep researchers within mental health. Concerning research funding, the share of core funding is deemed too low while European and national grant-application procedures appear inefficient and do not cover all fields of research.These results give a preliminary insight in the issues of current mental health research in Europe. After roll-out of the consultation to the entire mental health research community and a second expert panel, final recommendations will be formulated.
866 – Depression Outcome Among Minority Patients Treated Under Collaborative Care Management
Authors: De Jesus R. ,   DIAMOND Group
Published: July 2013

The collaborative care model (CCM) using care managers, has been reported to be more effective than usual care in depression management across various ethnic groups (1). It potentially may contribute to ameliorating racial disparity in depression care (2). The model was adopted at our institution in March 2008.This study aimed to compare 6 month treatment outcomes among minority patients enrolled under the CCM to those under usual care. Using the registry, de-identified data of minority patients defined as non-Caucasian individuals who meet criteria for CCM enrollment, defined as age 18 or over with initial PHQ-9 score of 10 or higher, from March 2008 were reviewed. Initial and 6-month PHQ-9 scores were compared to evaluate response and remission rates in both groups. Response is defined as a 50% reduction in PHQ-9 score from baseline while remission is defined as PHQ-9 score of 5 or less. Data was analyzed using Pearson chi-square and t-test.Of the 135 minority patients diagnosed with depression, 70% (n=94) were female. Majority were enrolled in CCM (n=105). Initial mean PHQ-9 score did not differ between the 2 groups. At 6 months, those under CCM had response rate of 75% compared to 33% in usual care. Remission rate at 6 months was 55% among patients in CCM and 12% in usual care.ConclusionAmong minority patients with depression, the CCM is significantly more effective in achieving treatment response and remission compared to usual care. Adaptation of this model across various population groups should be considered.