bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of factors influencing the quality of life of residents living close to Northwest Solid Waste Treatment Complex Cu Chi districts, Ho Chi Minh City
Authors: Mai Le Thi Tuyet , Chau Nguyen Lam Hong , Thao Do Phuong , Anh Hoang 
Published: June 2024

Abstract
Ho Chi Minh City (HCMC) grapples with a significant surge in waste generation, a consequence of urban expansion and development. The escalating waste poses a threat to the well-being of residents, particularly those in proximity to waste treatment facilities. This study delves into the impact of the Northwest Solid Waste Treatment Complex (NSWTC), a key waste treatment facility in HCMC, on residents residing in its immediate vicinity. The assessment encompasses 120 subjects living within a semi-permanent radius of 5 km from NSWTC. The residents’ Quality of Life (QoL) is quantitatively evaluated using the WHO QoL assessment scale (WHOQOL-BREF), comprising 26 survey questions categorized into four domains: living environment, physical health, psychological well-being, and socio-economic conditions. The identification of these domains is facilitated through bivariate and multivariate logistic analyses. Utilizing SPSS 20.0 software for data analysis, the findings reveal that a noteworthy 76.7% of subjects exhibit a subpar QoL. The overall QoL score, averaging 49.08 ± 18.82, falls considerably below acceptable standards, attributing this decline to environmental factors such as odours, dust, falling waste, water quality, and socio-economic conditions.
Assessing water quality of the Saigon River under the impact of industrial wastewater incidents
Authors: Thuy Nguyen Thi Diem , Mai Nguyen Thi Huynh , Linh Do Quang 
Published: June 2024

Abstract
The Saigon River, as its economic potential and clusters and industrial parks evolve, is threatened by a high potential for water pollution. The objective is to evaluate the water quality (BOD5 and COD) under the influence of industrial wastewater incidents in the Saigon River using MIKE 21FM model. The results of model calibration and validation have high reliability with NSE values larger than 0.65 for the flow simulation and percentage error values less than 25% for the water quality simulation. Subsequently, the study proceeds to develop hypothetical scenarios in case untreated wastewater from industrial parks is charged directly into the Saigon River with actual discharge volumes of 15,811 m3/day and 30,000 m3/day. The results indicated that when an incident occurs at a location 1.3 km upstream from the Hoa Phu pumping station with a discharge volume of 15,811 m3/day, that has the most consequential impact, in terms of time and concentration of water pollutants on the pumping station. Specifically, the water quality at the pumping station area experiences a remarkable decrease after one and three hours of incidents in the dry and rainy seasons, respectively. In general, the impacts of industrial wastewater incidents vary depending on their location. An incident beneath the Hoa Phu pumping station on the Saigon River is expected to have a faster impact on the raw water source during the dry season compared to the rainy season.
Prediction of surface urban heat island in Ho Chi Minh City, Viet Nam using remote sensing and logistic regression model
Authors: Pham Chi Cuong , Nguyen Ngoc Tuyen , Tran Quang Tra , Nguyen Nhu Ngoc 
Published: June 2024

Abstract
Urban heat island is a concerning environmental issue in major cities, particularly in Ho Chi Minh City. With a high rate of urbanization, the city’s extensive impervious surface area contributes to land surface temperature increase, leading to the expansion of the urban heat island phenomenon. This study was conducted in the Ho Chi Minh city region from 2009 to 2020, images from Landsat 5 (TM) and Landsat 8 (OLI/TIRS) satellites were employed to estimate land surface temperature (LST), examine the spatial distribution of the urban heat island (SUHI), and analyze changes in impervious surface area (ISA). A logistic regression model was established to predict the relationship between SUHI and ISA, with the percentage of ISA calculated by the Kernel Density Estimation method (KDE). The results revealed that the impervious surface area in the city doubled from 2009 to 2020, accounting for 29.54% of the city’s area, which correlated with a significant expansion of SUHI from 37,000 ha to 53,000 ha. The SUHI predicting model exhibited good discrimination ability (AUC = 0.98) and total accuracy of 96% through Hosmer & Lemeshow Test in R. The probability of the predicted SUHI showed a high correlation (R2 = 0.885) with the actual SUHI. In areas where ISA increased from 60% to 80%, the probability of SUHI occurrence also increased from 52.85% to 98%. This study presented a novel approach, utilizing statistical modeling to accurately quantify SUHI based on changes in impervious surface density. This method can contribute to an effective evaluation of heat-related health risks, provide the government and urban planners with a precise orientation in management toward sustainable development.
Factors affecting the change of agricultural livelihoods of farmers adapting to water resource reduction in the highland area in An Giang province, Vietnam
Authors: Nguyen Cam T H , Febriamansyah Rudi , Pham Van H T , Tran Hieu V 
Published: June 2024

Abstract
Currently, water shortages are affecting agricultural production in the Mekong Delta region of Vietnam. Consequently, most farmers have changed their current cropping patterns to other patterns that need less water. The factors affecting this change have not so far been deeply analyzed, especially in the higher terrain areas of the delta. This study intends to identify and understand factors causing change in the agricultural livelihoods of farmers in the highland area of An Giang province. Farm household surveys (90 households) were used to collect information on the changes in agricultural livelihoods and identify the causal factors. Multinomial logistic regression was applied to analyze these affecting factors, based on variables in household livelihood assets. The results show that farmers have at least three livelihood choices: change from rice to vegetable, change from rice to rice and-vegetable, and change from rice to fruit. The results from multinomial logistic regression show that livelihood choices are affected by households’ types of assets: human (number of employees involved, perception of farmers); natural (cultivated land area, the distance between the water source and the cultivated land area); financial (household income); and social (relationship with friends and relatives). Therefore, to increase the sustainability of existing livelihood models, it is necessary to improve the capacity of farmers through technical training sessions, promote social networks within the farming community and provide financial support policies for farmers.
Troubles with Words
Authors: Strawson Galen 
Published: June 2024

AbstractChapter 1 discusses problems of mutual misunderstanding—both chronic and acute—that arise in philosophy on account of terminological divergences and unclarities. It considers how philosophers fall into thought ruts, and lock on to narrow ways of hearing particular words, in such a way that they cease to be able to respond rationally to arguments. It reviews the greatest catastrophe that has occurred in metaphysics in the last three centuries: the rise of ‘epistemologized metaphysics’. One classical example of epistemologized metaphysics is the illegitimate conversion of Hume’s non-metaphysical, semantic-cum-epistemological claim regarding what we can know about causation (only regularity) into a metaphysical claim about what causation is (only regularity). The chapter then briefly introduces the key notions of the book: stuff, quality, structure. And it defines naturalism in an unorthodox way: the first commitment of the true naturalist must be to qualia, or the reality of consciousness.
The Second Fusion/Fusing the Fusions
Authors: Strawson Galen 
Published: June 2024

AbstractChapter 6 argues for Stoff ist Kraft, the view that there are no metaphysically fundamental distinctions to be made between the phenomena of force, energy, power, causation, physical law, and natural necessity. Some of these terms have genuinely different uses, but this does not support any sort of metaphysical separatism with respect to their fundamental being. The chapter then argues, with Nietzsche, for a further identity: there is no fundamental distinction between a thing and its power/force/energy features. To think otherwise is to succumb to a separatist, staticist conception of stuff: a thing’s power features must also be reckoned to be among its intrinsic qualities and so (by the argument of Chapter 5) as part of its total qualitiedness—with which it is identical. So too a thing’s behaviour is as much part of its fundamental being as anything about it that can’t be counted as its behaviour.
Effectiveness of non-pharmacological interventions delivered at home for urinary and faecal incontinence with homebound older people: systematic review of randomised controlled trials
Authors: Buck Jackie , Fromings Hill Julia , Collins Rachael , Booth Joanne , Fleming Jane 
Published: June 2024

Abstract

Introduction
Incontinence is a common, distressing condition, most prevalent in older people. There is an unmet need for effective interventions to support continence. This review focuses on non-pharmacological interventions to reduce incontinence among homebound older people. Aim: to identify interventions with potential to be delivered by care workers, nurses or family members in a person’s home.

Methods
Multiple databases were searched until 15 September 2023 for randomised controlled trials reporting home-based interventions for incontinence for older people (≥65 years) living at home. Two reviewers independently screened titles, abstracts and papers against inclusion criteria, then assessed for the Risk of Bias (RoB2). A third reviewer resolved the discrepancies. Primary data were extracted and synthesised.

Results
A full-text review of 81 papers identified seven eligible papers (1996–2022, all USA), including n = 636 participants (561 women and 75 men). Two studies focusing on multicomponent behavioural interventions showed benefit, as did one study of transcutaneous tibial nerve stimulation self-administered through electrode-embedded socks. Three, which included cognitively impaired people, reported improvement with toileting assistance programmes, but the effects were not all significant. Results were inconclusive from a study examining the effects of fluid intake adjustments. Interventions were delivered by nurses, three in collaboration with family caregivers. No faecal incontinence interventions met the criteria.

Conclusion
There is scant evidence for continence supporting interventions delivered in older people’s own homes. With an ageing population often reliant on family or social care workers well-placed to support continence promotion and policy drives for services to support older people remaining at home, this evidence gap needs addressing.
Advancing research: a commentary on the untapped potential of acceptance and commitment therapy in alcohol use disorder treatment
Authors: Garel Nicolas , Brodsky Kimberly L , Ostacher Michael J 
Published: June 2024

Abstract
Alcohol use disorder poses a significant global health threat, with profound consequences for individuals, families, and communities, necessitating continued exploration of novel treatment approaches. Acceptance and Commitment Therapy, an evidence-based approach for various mental health disorders, offers promise in addressing alcohol use disorder as well, but controlled trials are lacking, highlighting a crucial gap in research.
A search for food extracts inhibiting ferroptosis using immortalized mouse embryonic fibroblasts derived from xCT knockout mice
Authors: Mori Yasushi , Abe Tsukumo , Masaya Nami , Igarashi Kiharu , Sato Hideyo , Kobayashi Sho 
Published: June 2024

Abstract
Depleting glutathione by xCT inhibition induces iron-dependent ferroptotic cell death, which is suppressed by lipophilic antioxidants. We screened food extracts with xCTKO-MEFs, identifying garlic extracts as particularly potent in inhibiting ferroptosis among the food extracts examined in this study. xCTKO-MEFs can serve as a convenient tool for identifying food extracts that are effective in inhibiting ferroptosis.
Transfer learning of condition-specific perturbation in gene interactions improves drug response prediction
Authors: Bang Dongmin , Koo Bonil , Kim Sun 
Published: June 2024

Abstract

Summary
Drug response is conventionally measured at the cell level, often quantified by metrics like IC50. However, to gain a deeper understanding of drug response, cellular outcomes need to be understood in terms of pathway perturbation. This perspective leads us to recognize a challenge posed by the gap between two widely used large-scale databases, LINCS L1000 and GDSC, measuring drug response at different levels—L1000 captures information at the gene expression level, while GDSC operates at the cell line level. Our study aims to bridge this gap by integrating the two databases through transfer learning, focusing on condition-specific perturbations in gene interactions from L1000 to interpret drug response integrating both gene and cell levels in GDSC. This transfer learning strategy involves pretraining on the transcriptomic-level L1000 dataset, with parameter-frozen fine-tuning to cell line-level drug response. Our novel condition-specific gene–gene attention (CSG2A) mechanism dynamically learns gene interactions specific to input conditions, guided by both data and biological network priors. The CSG2A network, equipped with transfer learning strategy, achieves state-of-the-art performance in cell line-level drug response prediction. In two case studies, well-known mechanisms of drugs are well represented in both the learned gene–gene attention and the predicted transcriptomic profiles. This alignment supports the modeling power in terms of interpretability and biological relevance. Furthermore, our model’s unique capacity to capture drug response in terms of both pathway perturbation and cell viability extends predictions to the patient level using TCGA data, demonstrating its expressive power obtained from both gene and cell levels.

Availability and implementation
The source code for the CSG2A network is available at https://github.com/eugenebang/CSG2A.
METTL14 mediates nerve growth factor-stimulated testosterone synthesis in porcine theca cells
Authors: Luo Yuxin , Zhao Yun , Zhang Boqi , Chen Tong , Chen Xue , Shen Caomeihui , He Guitian , Cao Maosheng , Chen Lu , Wang Yueying , Wang Nan , Zong Jinxin , Zhou Xu , Li Chunjin 
Published: June 2024

Abstract
Ovarian theca cells produce testosterone, which acts as a vital precursor substance for synthesizing estrogens during follicular development. Nerve growth factor (NGF) has been shown to participate in reproductive physiology, specifically to follicular development and ovulation. There is currently no available data on the impact of NGF on testosterone synthesis in porcine theca cells. Furthermore, m6A modification is the most common internal modification in eukaryotic mRNAs that are closely associated with female gametogenesis, follicle development, ovulation, and other related processes. It is also uncertain whether the three main enzymes associated with m6A, such as Writers, Erasers, and Readers, play a role in this process. The present study, with an in vitro culture model, investigated the effect of NGF on testosterone synthesis in porcine theca cells and the role of Writers-METTL14 in this process. It was found that NGF activates the PI3K/AKT signaling pathway through METTL14, which regulates testosterone synthesis in porcine theca cells. This study will help to further elucidate the mechanisms by which NGF regulates follicular development and provide new therapeutic targets for ovary-related diseases in female animals.
Summary Sentence
The present study investigated the effect of NGF on testosterone synthesis in porcine theca cells. It was found that NGF activates the PI3K/AKT signaling pathway through METTL14, which regulates testosterone synthesis in porcine theca cells.
CPC10 A curious case of recurrent melanomas and field change confined to the left thigh over 25 years
Authors: Hussain Khawar , Chung Jenny , Goss Charlotte , Fernandez Carolina , Dave Siddarth , Weir Justin , Craythorne Emma , Fearfield Louise 
Published: June 2024

Abstract
A 52-year-old woman presented in 1999 with an atypical erythematous plaque on her left thigh containing a flesh-coloured nodule surrounded by four pink scaly papules. She had no significant past medical, drug or family history. Excision of the nodule revealed an amelanotic malignant melanoma (MM) of Breslow thickness (BT) 1 mm. Biopsies of the four surrounding lesions confirmed satellite MM in one, with no radiological evidence of metastases. She received adjuvant interferon therapy for 1 year. Repeat imaging was normal. Eighteen years later, she developed a new pigmented lesion on her left thigh confirmed as MM (0.9 mm BT), with three further erythematous plaques on the left thigh reported as (i) proximal left-thigh MM (1.08 mm BT), (ii) middle-left-thigh amelanotic MM (0.6 mm BT) and (iii) left-thigh MM (1.7 mm BT). Wide local excision (WLE) failed to obtain histological clearance of (i) and (iii), with mildly dysplastic naevus and melanoma in situ (MiS), respectively, at the peripheral margins. Reflective confocal microscopy (RCM) was used to guide further surgery, with continued incompletely excised MiS and field change at the margins. Eighteen months later she presented with another MiS and MM (0.5 mm BT) on the left thigh. Imiquimod 5% once daily for 8 weeks to the affected area was instigated to treat any residual in situ component. BRAF, CDKN2A, CDK4 and BAP1 showed no pathological variants, and xeroderma pigmentosum testing was negative. Six months later a further MM (1.2 mm BT) on the left thigh was treated with WLE and skin graft. Sentinel lymph node biopsy was deemed not possible due to previous multiple surgical excisions. Ultrasound groin scan and whole-body FDG-PET computed tomography showed no occult metastases. Several months later, another MM (0.5 mm BT) was excised at the edge of the graft site. Residual dysplastic lentiginous proliferation at the edge with no MM was reported on the 1-cm WLE. This represents a complex case with recurrent MM, often indistinguishable from primary MM histologically. Widespread dysplastic field change evidenced by involvement at the edges of the WLEs and the RCM images was also challenging. RCM can be a noninvasive adjunct in identification of superficial skin tumours. Adjuvant interferon therapy for high-risk MM has demonstrated an increase in disease-free survival (Petrella T, Verma S, Spithoff K et al. Adjuvant interferon therapy for patients at high risk for recurrent melanoma: an updated systemic review and practice guideline. Clin Oncol 2012; 24: 413–23). This may have contributed to the 18-year delay between her first and second melanomas, as well as her complex, recurrent presentations and ongoing local confinement of the MM to the left thigh with lack of disease progression.
P006 Tumour necrosis factor-α-induced lupus panniculitis: one case report and literature review
Authors: Grechin Cristina , Doheny Jane , Pilson Keith , Howard Donough , Roche Muireann 
Published: June 2024

Abstract
The anti-tumour necrosis factor (TNF)-α therapies have revolutionized the management of multiple chronic inflammatory diseases. However, a wide range of adverse events have been reported over the years (Durand A, Goussot J, Thiolat D et al. Anti-tumour necrosis factor α-induced lupus erythematosus panniculitis. J Eur Acad Dermatol Venereol 2017; 3: e307–48). Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus (1–3% of cutaneous lupus erythematosus), with just two reports of cases potentially triggered by anti-TNF-α therapies (Durand et al.; and Lee H, Kim DS, Chung DY. Adalimumab-induced lupus panniculitis. Letter to the editor. Lupus 2014 ; 23: 1443–4). We report a case of a 62-year-old woman with rheumatoid arthritis treated with etanercept, who previously had not responded to multiple therapies including methotrexate, sulfasalazine and adalimumab. She presented with an 18-month history of a rash on her left upper arm that developed 6 months after initiation of adalimumab. Despite a switch to etanercept, the rash continued to evolve. Examination revealed several discrete telangiectatic plaques on the left upper arm with marked subcutaneous atrophy, clinically suspicious for lupus panniculitis. A similar area was found on the right upper arm. Two punch biopsies for haematoxylin and eosin staining were performed. Histology revealed a thin epidermis with a slightly thickened basement membrane, chronic inflammation at the dermoepidermal junction with lymphocyte exocytosis, transdermal perivascular chronic inflammation and mild lymphoplasmacytic lobular inflammation within the subcutis consistent with lupus panniculitis. Following a switch by her rheumatologist to certolizumab pegol for active rheumatoid arthritis, she had an episode of acute lupus panniculitis requiring hospitalization. A trial of hydroxychloroquine (5 mg kg−1 real bodyweight) and mepacrine in conjunction with potent topical steroids failed to control her panniculitis. Her anti-TNF-α therapies were suspected as a potential cause. Certolizumab was changed to a Janus kinase inhibitor (baricitinib), and dapsone was added to the current treatment. A considerable clinical improvement was noticed. Moreover, her LEP has been in remission for 18 months without any flares. Our literature review highlights only two case of lupus panniculitis induced by anti-TNF-α agents. Lee et al. published a case of adalimumab-induced LEP for first time in 2014, followed by Durand et al., who reported the second case of LEP after 24 months of TNF-α treatment. Interestingly, both patients were female and had known rheumatoid arthritis. In conclusion, our case report and literature review highlights that anti-TNF-α therapies can induce lupus panniculitis, especially in the cohort of patients with rheumatoid arthritis. Is there any relation between these two diseases or is it just a coincidence? Further research in this field is required.