bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary Design of a Lightweight Composite Backing Structure for a Satellite Antenna
Authors: Nutu Emil , Vintila Ionut Sebastian , Stuparu Florin , Pelin George , Jiga Gabriel Gheorghe 
Published: August 2024

AbstractThe paper consists of a preliminary design and analysis of a lightweight composite backing structure for a side deployable solid mesh reflector intended for telecom application in the Ka‐Band. As the entire antenna reflector must withstand the forces related to the launching loads, the focus is addressed to the stiffness of the composite backing structure, so that the reflective metallic mesh will not be affected during launching phase, thus with no influence over the possible deformation of the mesh and on its radio frequency performance. It is shown that the proposed concept withstands the imposed launching requirements with a compromise on mass properties.
Thermoforming of Printed Conductive Silver on Flexible Substrates
Authors: Imparato Antonio , Mauro Anna De Girolamo Del , Ricciardi Maria Rosaria , Antonucci Vincenza 
Published: August 2024

AbstractScreen printing is an interesting technique for the high‐volume production of printed conductive electronic devices on flexible substrates. In this study, silver conductive lines have been produced by screen‐printing technique on flexible PEN substrates and optimized in order to provide maximum electrical conduction. The geometry of the obtained conductive samples has been modified by performing thermoforming tests in a mold with complex geometry, replicating a significant section of dashboard coating. The functionality of the shape‐deformed substrates has been assessed.
Biopolymer‐Based Nanogels Synthesis, Characterization, and Stability for Doxorubicin Encapsulation and Delivery
Authors: Fernández‐Solís Karla Gricelda , González Guillermo Toriz , Ochoa Edgar Benjamín Figueroa , Rosselgong Julien , Mijares Eduardo Mendizabal , Bravo‐Anaya Lourdes Mónica 
Published: August 2024

AbstractNanogels are nanostructures with dimensions within the nanoscale, composed of crosslinked polymers through their functional groups. Nanogels can display sensitiveness to stimuli, such as pH or temperature. This characteristic has been used in the design of new platforms for the transport and release of active ingredients. Biopolymer‐based nanogels are of great interest due to their biodegradability, biocompatibility, nontoxicity, and among others. In this project, pH‐responsive nanogels are synthesized through a novel methodology, using two polysaccharides classified as safe, biocompatible, and easily accessible materials, i.e., chitosan (CS) and maltodextrin (MD). A reductive amination reaction between CS and partially oxidized MDs allows to synthesized MD/CS nanogels with sizes ranging from 90 ± 5 to 194 ± 40 nm and with a colloidal stability up to 7 weeks. It is found that the variation of nanogels size and charge depends on CS concentration, molecular weight, and pH, as well as on the % oxidation of the MD. As evidence of nanogels pH‐responsiveness, an increase of size and ζ‐potential is observed by decreasing the pH. This size increase is attributed to the swelling of the nanogels upon a change in pH. Finally, doxorubicin is encapsulated in MD/CS nanogels, with a loading capacity up to 57%.
Recryopreservation impairs blastocyst implantation potential via activated endoplasmic reticulum stress pathway and induced apoptosis
Authors: Wang Meng , Zhou Juepu , Long Rui , Li Yuehan , Gao Limin , Mao Ruolin , Wang Xiangfei , Guo Na , Jin Lei , Zhu Lixia 
Published: August 2024

AbstractRecryopreservation (recryo) is occasionally applied in clinical, while the underlying mechanism of impaired clinical outcomes after recryo remains unclear. In this study, frozen embryo transfer (FET) cycles of single blastocyst transfer in an academic reproductive medicine center were enrolled. According to the number of times blastocysts experienced cryopreservation, they were divided into the cryopreservation (Cryo) group and the Recryo group. Donated human blastocysts were collected and detected for mechanism exploration. It was found that recryo procedure resulted in impaired blastocyst developmental potential, including decreased implantation rate, reduced biochemical pregnancy rate, declined clinical pregnancy rate, higher early miscarriage rate, and lower live birth rate. Moreover, recryo led to impaired trophectoderm (TE) function, exhibiting lower human chorionic gonadotropin levels 12 days after FET. In addition, single‐cell RNA sequencing showed that the expression of genes involved in cell adhesion and embryo development were altered. More specifically, activated endoplasmic reticulum (ER) pathway and induced apoptosis were further verified by immunofluorescence and terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling (TUNEL) assay involving in the recryo procedure. In conclusion, recryo could interfere with the process of blastocyst implantation by impairing TE function, affecting blastocyst adhesion, activating ER stress pathway and inducing apoptosis. It provides caution to embryologists about the potential risk of recryopreservation.
Prediction of CD8+T lymphocyte infiltration levels in gastric cancer from contrast‐enhanced CT and clinical factors using machine learning
Authors: Xie Wentao , Jiang Sheng , Xin Fangjie , Jiang Zinian , Pan Wenjun , Zhou Xiaoming , Xiang Shuai , Xu Zhenying , Lu Yun , Wang Dongsheng 
Published: August 2024

AbstractBackgroundCD8+ T lymphocyte infiltration is closely associated with the prognosis and immunotherapy response of gastric cancer (GC). For now, the examination of CD8 infiltration levels relies on endoscopic biopsy, which is invasive and unsuitable for longitude assessment during anti‐tumor therapy.PurposeThis work aims to develop and validate a noninvasive workflow based on contrast‐enhanced CT (CECT) images to evaluate the CD8+ T‐cell infiltration profiles of GC.MethodsGC patients were retrospectively and consecutively enrolled and randomly assigned to the training (validation) or test cohort at a 7:3 ratio. All patients were binary classified into the CD8‐high (infiltrated proportion ≥ 20%) or CD8‐low group (infiltrated proportion < 20%) group. A total of 1170 radiomics features were extracted from each presurgical CECT series. After feature selection, fifteen radiomics features were transmitted to three independent machine‐learning models for the computation of predictive radiological scores. Multilayer perceptron (MLP) was applied to merge the radiological scores with clinical factors. The predictive efficacy of the radiological scores and of the combined model was evaluated by receiver operating characteristic curve, calibration curve, and decision curve analysis in both the training and test cohorts.ResultsA total of 210 patients were enrolled in this study (mean age: 63.22 ± 8.74 years, 151 men), and were randomly assigned to the training set (n = 147) or the test set (n = 63). The merged radiological score was correlated with CD8 infiltration in both the training (p = 1.8e−10) and test cohorts (p = 0.00026). The combined model integrating the radiological scores and clinical features achieved an area under the curve (AUC) value of 0.916 (95% CI: 0.872–0.960) in the training set and 0.844 (95% CI: 0.742–0.946) in the test set for classifying CD8‐high GCs. The model was well‐calibrated and exhibited net benefit over “treat‐all” and“treat‐none” strategies in decision curve analysis.ConclusionsArtificial intelligent systems combining radiological features and clinical factors could accurately predict CD8 infiltration levels of GC, which may benefit personalized treatment of GC in the context of immunotherapy.
Reliable multi‐modal medical image‐to‐image translation independent of pixel‐wise aligned data
Authors: Zhou Langrui , Li Guang 
Published: August 2024

AbstractBackgroundThe current mainstream multi‐modal medical image‐to‐image translation methods face a contradiction. Supervised methods with outstanding performance rely on pixel‐wise aligned training data to constrain the model optimization. However, obtaining pixel‐wise aligned multi‐modal medical image datasets is challenging. Unsupervised methods can be trained without paired data, but their reliability cannot be guaranteed. At present, there is no ideal multi‐modal medical image‐to‐image translation method that can generate reliable translation results without the need for pixel‐wise aligned data.PurposeThis work aims to develop a novel medical image‐to‐image translation model that is independent of pixel‐wise aligned data (MITIA), enabling reliable multi‐modal medical image‐to‐image translation under the condition of misaligned training data.MethodsThe proposed MITIA model utilizes a prior extraction network composed of a multi‐modal medical image registration module and a multi‐modal misalignment error detection module to extract pixel‐level prior information from training data with misalignment errors to the largest extent. The extracted prior information is then used to construct a regularization term to constrain the optimization of the unsupervised cycle‐consistent Generative Adversarial Network model, restricting its solution space and thereby improving the performance and reliability of the generator. We trained the MITIA model using six datasets containing different misalignment errors and two well‐aligned datasets. Subsequently, we conducted quantitative analysis using peak signal‐to‐noise ratio and structural similarity as metrics. Moreover, we compared the proposed method with six other state‐of‐the‐art image‐to‐image translation methods.ResultsThe results of both quantitative analysis and qualitative visual inspection indicate that MITIA achieves superior performance compared to the competing state‐of‐the‐art methods, both on misaligned data and aligned data. Furthermore, MITIA shows more stability in the presence of misalignment errors in the training data, regardless of their severity or type.ConclusionsThe proposed method achieves outstanding performance in multi‐modal medical image‐to‐image translation tasks without aligned training data. Due to the difficulty in obtaining pixel‐wise aligned data for medical image translation tasks, MITIA is expected to generate significant application value in this scenario compared to existing methods.
Drug Survival on First Biologic Therapy Among Late‐Onset Rheumatoid Arthritis Patients Compared to Early‐Onset Patients: A Population‐Based Cohort Study
Authors: Jeries Helana , Daood Rula , Hijazi Basem , Golan‐Cohen Avivit , Green Ilan , Merzon Eugene , Naffaa Mohammad E. , Hassan Fadi 
Published: August 2024

ABSTRACTIntroductionRheumatoid arthritis (RA) patients can be divided according to the age of disease onset and classified as late‐onset RA ≥ 60 years old or early‐onset RA < 60 years old. Current treatment guidelines do not stipulate any preference regarding the biologic that should be used first in the late‐onset group. This study aims to compare the drug survival times on first biological treatment between late and early‐onset RA patients.MethodsThis is a population based cohort study using the medical records of Leumit healthcare services. We included all eligible RA patients between 2000 and 2017. RA patients were divided into late‐ and early‐onset RA groups and compared according to drug survival time on the first biological therapy.ResultsThe final cohort included 3814 RA patients, 2807 (73.6%) of whom had early‐onset RA. Overall, biologic disease‐modifying anti‐rheumatic drugs (bDMARDs) were used more often among early‐onset compared to late‐onset patients (16.9% vs. 7.8%, p < 0.001). Among early‐onset patients, etanercept was associated with the longest drug survival time on the first biologic, and adalimumab and infliximab were associated with the longest drug survival times among late‐onset patients. No differences were observed in drug survival times between late and early‐onset patients on the first bDMARD, except for abatacept and golimumab with longer drug survival time among early‐onset patients.ConclusionLate‐onset RA patients were treated with biologics to a lesser extent than early‐onset patients, but no differences were observed in drug survival times at the first bDMARD between the two groups.
Implementing early feeding after liver transplant using implementation frameworks: A multimethod study
Authors: Takefala Tahnie G. , Mayr Hannah L. , Doola Raeesa , Johnston Heidi E. , Hodgkinson Peter J. , Andelkovic Melita , Macdonald Graeme A. , Hickman Ingrid J. 
Published: August 2024

AbstractBackgroundEvidence‐based guidelines (EBGs) in the nutrition management of advanced liver disease and enhanced recovery after surgery recommendations state that normal diet should recommence 12–24 h following liver transplantation. This study aimed to compare postoperative nutrition practices to guideline recommendations, explore clinician perceptions regarding feeding after transplant surgery, and implement and evaluate strategies to improve postoperative nutrition practices.MethodsA pre‐post multimethod implementation study was undertaken, guided by the knowledge‐to‐action framework. A retrospective chart audit of postoperative dietary practice and semistructured interviews with clinicians were undertaken. Implementation strategies were informed by the Consolidated Framework for Implementation Research–Expert Recommendations for Implementing Change matching tool and then evaluated.ResultsAn evidence‐practice gap was identified, with the median day to initiation of nutrition (free‐fluid or full diet) on postoperative day (POD) 2 and only 25% of patients aligning with the EBGs. Clinician interviews identified belief in the importance of nutrition, with variation in surgical practice in relation to early nutrition, competing clinical priorities, and vulnerabilities in communication contributing to delays in returning to feeding. An endorsed postoperative nutrition protocol was implemented along with a suite of theory‐ and stakeholder‐informed intervention strategies. Following implementation, the median time to initiate nutrition reduced to POD1 and alignment with EBGs improved to 60%.ConclusionThis study used implementation frameworks and strategies to understand, implement, and improve early feeding practices in line with EBGs after liver transplant. Ongoing sustainability of practice change as well as the impact on clinical outcomes have yet to be determined.
Prevention of complications for hospitalized patients receiving parenteral nutrition: A narrative review
Authors: Al‐Zubeidi Dina , Davis Mary Beth , Rahhal Riad 
Published: August 2024

AbstractHospitalized patients may benefit from parenteral nutrition to address their compromised nutrition status attributed to limited oral/enteral intake and increased nutrient/energy requirement during acute illness. Parenteral nutrition, however, can be associated with many complications that can negatively impact patient outcomes. In this review, we focus on potential metabolic and catheter‐related complications associated with parenteral nutrition use. We report on potential risk factors for such complications and highlight strategies for prevention and early recognition. To optimize outcomes, key findings include the creation and implementation of evidence‐based protocols with proven efficacy. For each hospital unit delivering parenteral nutrition to patients, tracking compliance with established protocols and patient outcomes is crucial for ongoing improvement through identification of gaps, proper reeducation and training, and ongoing refinement of care protocols. Establishment of specialized inpatient nutrition support teams should be considered.
Synoptic operative reports for pediatric surgical oncology
Authors: Baertschiger Reto M. , Polites Stephanie , Fusco Joseph C. , Roach Jonathan P. , Christison‐Lagay Emily , Malek Marcus , Gow Kenneth W. 
Published: August 2024

AbstractSynoptic operative notes for pediatric surgical oncology provide standardized and structured documentation of surgical procedures performed on pediatric patients with cancer. These reports capture essential details such as preoperative diagnosis, intraoperative findings, surgical technique, and tumor characteristics in a concise and uniform format. By promoting consistency, accuracy, and completeness in reporting, synoptic operative notes facilitate effective communication among multidisciplinary healthcare teams, enhance quality assurance efforts, and streamline data extraction for research purposes. The integration of synoptic reporting within electronic medical record systems further enhances accessibility and usability, ensuring efficient documentation practices and improved patient care outcomes in pediatric surgical oncology.
Venetoclax for pediatric patients with newly diagnosed acute myeloid leukemia
Authors: Gibson Amber , Dickson Samantha , McCall David , Garcia Miriam , Connors Jeremy , He Jiasen , Roth Michael , Nunez Cesar , Cuglievan Branko 
Published: August 2024

AbstractThis retrospective study at the University of Texas MD Anderson Cancer Center evaluated frontline venetoclax combination therapy in 11 pediatric/adolescent patients with acute myeloid leukemia (AML). Despite the small sample size and retrospective nature, the treatment demonstrated safety and potential efficacy, with most patients achieving early complete remission. Adverse events were consistent with other AML therapies, and no discontinuations due to toxicity occurred. While acknowledging study limitations, including selection bias and diverse concurrent therapies, this research underscores the promising role of venetoclax in pediatric AML. Further investigation is crucial to validate its long‐term efficacy in this population.
High‐Resolution Haplotyping of the PAH Gene Enables Early Gestation Noninvasive Prenatal Diagnosis of Phenylketonuria and Evolution Analysis of Recurrent Pathogenic Variations
Authors: Zhu Jingqi , Zhao Zhenhua , Li Shaojun , Zhou Yifan , Kong Lingrong , Fu Xinyu , Li Huanyun , Feng Jun , Tang Weiqin , Wu Di , Kong Xiangdong 
Published: August 2024

ABSTRACTBackgroundThe clinical performance of RHDO‐based NIPD for PKU during early gestation remains under‐evaluated. Furthermore, studies focused on SNP loci obtained by next‐generation sequencing to analyze the genetic evolution of pathogenic variations in PKU is limited.MethodsMaternal peripheral blood, along with proband and paternal samples, was collected between 7 and 12 weeks of gestation. The PAH gene and surrounding high heterozygosity SNPs were targeted for enrichment and sequencing. Fetal genotypes were inferred using RHDO‐based NIPD. High‐resolution PAH haplotypes were used for the analysis of two common pathogenic variants in the Chinese population: c.728G>A and c.1238G>C.ResultsSixty one PKU families participated with an average fetal fraction of 6.08%. The median gestational age was 8+6 weeks. RHDO‐based NIPD successfully identified fetal genotypes in 59 cases (96.72%, 59/62). Two cases failed because of insufficient informative SNPs. In addition, a recombination event was assessed in one fetus of 59 cases. Six, and three haplotypes were identified for c.728G>A(p.Arg243Gln) and c.1238G>C(p.Arg413Pro), respectively. Hap_3 and hap_8 were identified as the ancestral haplotypes for these pathogenic variants, with other haplotypes arising from mutations or recombination based on these ancestral haplotypes.ConclusionsThis study validates the feasibility of an RHDO‐based assay for NIPD of PKU in early pregnancy and introduces its application in the demonstration of founder effects in recurrent pathogenic variations, offering new insights into the evolutionary analysis of PAH variations.
Composite materials based on slide‐ring polyrotaxane structures for optoelectronics
Authors: Resmerita Ana‐Maria , Asandulesa Mihai , Farcas Aurica 
Published: August 2024

AbstractComposite material based on polyethylene glycol (PEG) and polypyrrole (PPy) polyrotaxanes both encapsulated into α‐cyclodextrins (α‐CDs) macrocycle molecules was synthesized by cross‐linking reaction. The effect of PPy‐αCD polyrotaxane incorporation into the PEG‐αCD polyrotaxane matrix, on the structural, morphological, thermal, and dielectric properties was evaluated and compared to the reference material. Scanning electron microscopy spectroscopy indicates different surface morphologies of this material in comparison to the reference one. In addition, the contact angle measurements and surface free energy attest a hydrophilic surface, while the reference material exhibits a hydrophobic surface. More than that, the presence of the PPy‐αCD cross‐linked into the matrix has a beneficial effect on the thermal properties. The composite material shows an enhanced dielectric constant value of 31,365 at 10 Hz frequency compared to the 38.2 of the reference material, and higher dielectric loss (62,398 vs. 80 at 10 Hz, respectively). The conductivity measurements at 10 Hz frequency indicated for the reference material the value 4.5 × 10−11, while for the material with PPy‐αCD polyrotaxane, the conductivity is three orders of magnitude higher (3.5 × 10−8) confirming the improvements of the electrical properties.
Development of air therapy as a novel therapeutic branch in the field of rehabilitation
Authors: Mohamed Ayman A. 
Published: August 2024

AbstractBackground and PurposeDeveloping technology in the field of rehabilitation is vital to accelerate recovery and decrease the side effects of current modalities. Rehabilitation is a challenging science in which the main challenge is not just treating the patient but also to shorten the rehabilitation time and avoid harmful effects. Thus, this review demonstrates the possible design and effects of air therapy as a novel treatment branch besides hydrotherapy, electrotherapy, and manual therapy in the field of rehabilitation.MethodsThe search was conducted over clinical trials, literature reviews, and systematic reviews on the possible effects of treatments that may have similar effects to the newly developed air therapy. This search was conducted in the Web of Science, Scopus, EBSCO, and Medline databases.ResultsAir therapy could be used to improve the function of mechanoreceptors, improve circulation and microcirculation, decrease pain, the release of trigger points, regain the elasticity of soft tissues, treat acute and chronic inflammations, decrease muscle cramps and spasticity, strengthen muscle, and decrease muscle fatigue and Decreasing muscle fatigue and delayed muscle soreness.ConclusionAir therapy is a novel treatment modality that can be used effectively in the field of rehabilitation. Air therapy could be a valuable and safe treatment in rehabilitation.