bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jaboticaba (Plinia jaboticaba (Vell.) Berg) polyphenols alleviate skeletal muscle insulin resistance by modulating PI3K/Akt/GLUT-4 and AMPK signaling pathways in diet-induced obese mice
Authors: Pessoa Érika V. M. , Moura Márcio H. C. , Rodrigues Larissa , Rossi e Silva Rafaela , Castro Érique , Festuccia William T. , Donado-Pestana Carlos M. , Genovese Maria Inés 
Published: August 2024

AbstractSkeletal muscle responds for most of the insulin-stimulated glucose disposal at postprandial state, impacting glucose homeostasis. Polyphenols were shown to prevent obesity-associated glucose intolerance and peripheral insulin resistance in animal models, but the implication of skeletal muscle to these effects is unclear. We investigated the role of polyphenolic extracts from jaboticaba (Plinia jaboticaba (Vell.) Berg) (PEJ), a Brazilian native species, on skeletal muscle insulin resistance in diet-induced obese mice. PEJ administration was associated with an increase in skeletal muscle protein content of glucose transporter-4 (GLUT-4) and AMP-activated protein kinase (AMPK) phosphorylated at Thr172. PEJ also reduced skeletal muscle mRNA levels of inflammatory genes nuclear factor-ҡB (NF-κB), tumoral necrose factor-α (TNF-α), interleukin 1β (IL-1β), and c-Jun N-terminal kinase (JNK). This study demonstrates that polyphenols from jaboticaba may be a valuable therapeutic agent in the management and prevention of obesity-associated metabolic disorders by reducing skeletal muscle obesity-associated insulin resistance and inflammation.
Graphical Abstract
Relationship between the efficacy and adverse effects of methotrexate and gene polymorphism
Authors: Zhao Xin , Wu Pan , Yang Zhi , Miao Rong-Rong 
Published: August 2024

AbstractMethotrexate is a widely used drug in clinical practice for the treatment of collagen vascular diseases and malignant tumors. It has good anti-inflammatory and anti-proliferative effects, but the cytotoxicity of methotrexate can cause various adverse reactions in patients. Studies have shown that the sensitivity and tolerance of different individuals to methotrexate is different. There are many reasons for this difference. Among them, genetic polymorphism is one of the main factors that cause individual differences. This article provides an overview of the genetic polymorphisms of key proteins involved in methotrexate metabolism and transport, such as MTHFR, FPGS, γ-GGH, ABC transporter, OATPs, SLC, TS and DHFR, are related to their efficacy and adverse reactions. The aim is to clarify the impact of genetic polymorphisms on the efficacy and adverse effects of methotrexate at the pharmacogenomic level, in order to provide a basis for the clinical application of methotrexate.
Adrenal Suppression From Vamorolone and Prednisone in Duchenne Muscular Dystrophy: Results From the Phase 2b Clinical Trial
Authors: Ahmet Alexandra , Tobin Rebecca , Dang Utkarsh J , Rooman Raoul , Guglieri Michela , Clemens Paula R , Hoffman Eric P , Ward Leanne M 
Published: August 2024

Abstract

Context
Vamorolone, a novel “dissociative” steroid, demonstrated similar efficacy in muscle function relative to prednisone 0.75 mg/kg/day but improved linear growth and bone turnover markers in a randomized trial of pediatric Duchenne muscular dystrophy (DMD).

Objectives
To determine the frequency of adrenal suppression (AS) induced by vamorolone and prednisone in pediatric DMD and to assess cortisol thresholds using a monoclonal antibody immunoassay.

Methods
Post hoc analysis of cortisol levels was performed on data from a randomized, double-blind, placebo- and prednisone-controlled 24-week trial of vamorolone with a 24-week crossover extension. Morning and ACTH-stimulated cortisol levels were measured using the Elecsys II immunoassay, with AS defined as a stimulated cortisol of &lt;500 nmol/L (“historical threshold”) and &lt;400 nmol/L (“revised threshold”).

Results
Mean age at enrolment was 5.41 ± 0.86 years (n = 118). At week 24, the proportion of participants with AS using the historical and revised cortisol thresholds, respectively, were as follows: prednisone 0.75 mg/kg/day = 100% (25/25) and 92.0% (23/25); vamorolone 6 mg/kg/day = 95.2% (20/21) and 90.5% (19/21); vamorolone 2 mg/kg/day = 84.2% (16/19) and 47.5% (9/19); and placebo = 20.0% (4/20) and 0% (0/20). Morning and peak ACTH-stimulated cortisol were strongly correlated in steroid-treated boys (Spearman correlation week 48 = 0.83).

Conclusion
AS after vamorolone and prednisone was frequent and vamorolone-associated AS appeared dose-dependent. A lower stimulated cortisol threshold may be appropriate when using a monoclonal assay. We recommend hydrocortisone for glucocorticoid stress dosing in patients receiving vamorolone.
(Grün) Open Access von unten organisieren: Erfahrungen und Ergebnisse aus dem Projekt GOAL
Authors: Corredera Nilsson Enrique , Andres Valérie 
Published: August 2024

Zusammenfassung
Die Wissens- und Publikationskultur von Fachhochschulen und Pädagogischen Hochschulen fokussiert auf angewandte Wissenschaft und Berufsalltag. Ihre Forschungsergebnisse richten sich häufig an ein Publikum am Rande der akademischen Welt. In der Open-Access-Landschaft wurden praxisorientierte Publikationen bisher jedoch wenig beachtet. In unserem Beitrag berichten wir über die Lösungen und die Organisation hinter dem Projekt GOAL, das die Förderung von Green OA bei praxisorientierten Zeitschriften in der Schweiz zum Ziel hat.
Development and validation of a novel 7α-hydroxy-4-cholesten-3-one (C4) liquid chromatography tandem mass spectrometry method and its utility to assess pre-analytical stability
Authors: Atkins Jonathan S. , Keevil Brian G. , Taylor Angela E. , Ludwig Christian , Hawley James M. 
Published: August 2024

Abstract

Objectives
7α-Hydroxy-4-cholesten-3-one (C4) is the common intermediary of both primary bile acids. C4 is recommended by the British Society of Gastroenterology for the investigation of bile acid diarrhoea (BAD) in patients with chronic diarrhoea. This project aimed to develop and validate an assay to quantitate C4 in serum and assess the stability of C4 in unseparated blood.

Methods
Accuracy was underpinned by calibrating to quantitative nuclear magnetic resonance analysis. C4 was analysed in a 96-well plate format with a deuterated C4 internal standard and liquid-liquid extraction. Validation followed the 2018 Food and Drug Administration guidelines. To assess C4 stability, healthy volunteers (n=12) donated 8 fasted samples each. Samples were incubated at 20 °C for up to 72 h and retrieved, centrifuged, aliquoted and frozen for storage at different time points prior to C4 analysis.

Results
The C4 method demonstrated excellent analytical performance and passed all validation criteria. The method was found to be accurate, precise, free from matrix effects and interference. After 72 h of delayed sample separation, C4 concentration gradually declined by up to 14 % from baseline. However, the change was not significant for up to 12 h.

Conclusions
We present a robust method of analysing serum C4, offering a convenient alternative to 75SeHCAT for BAD investigation. C4 was found to decline in unseparated blood over time; however, after 12 h the mean change was <5 % from baseline. Our results suggest C4 is suitable for collection from both primary and secondary care prior to gastroenterology referral.
GIT quotient of holomorphic foliations on ℂℙ2 of degree 2 and quartic plane curves
Authors: Alcántara Claudia R. , Vásquez Aquino Juan 
Published: August 2024

Abstract
We study the quotient variety of the space of foliations on

ℂ
⁢

ℙ
2

{\mathbb{CP}^{2}}

of degree 2 up to change of coordinates. We find the intersection Betti numbers of this variety. As a corollary, we have that these intersection Betti numbers coincide with the intersection Betti numbers of the quotient variety of quartic plane curves. Finally, we give an explicit isomorphism between the space of foliations of degree 2 with different singular points, without invariant lines and the space of smooth quartic plane curves.
A note on conjugacy of supplements in soluble periodic linear groups
Authors: Trombetti Marco 
Published: August 2024

Abstract
The aim of this short note is to prove that if G is a (homomorphic images of a) soluble periodic linear group and N is a locally nilpotent normal subgroup of G such that N and

G
/
N

{G/N}

have no isomorphic G-chief factors, then two supplements to N in G are conjugate provided that they have the same intersection with N. This result follows from well-known theorems in the theory of Schunck classes (see [A. Ballester-Bolinches and L. M. Ezquerro,
On conjugacy of supplements of normal subgroups of finite groups,
Bull. Aust. Math. Soc. 89 2014, 2, 293–299]), and it appeared as the main theorem of [C. Parker and P. Rowley,
A note on conjugacy of supplements in finite soluble groups,
Bull. Lond. Math. Soc. 42 2010, 3, 417–419].
Prevalence of restless legs syndrome during pregnancy and postpartum period
Authors: Lepuzanovic Muhamed , Sinanovic Osman , Aziraj-Smajic Vildana , Kapic Dzevada , Basagic Edin , Muftic Mirsad 
Published: August 2024

Abstract

Objectives
Restless legs syndrome (RLS) is a disease from the spectrum of movement disorders, the prevalence of which increases significantly during pregnancy and is associated with poor sleep, a drop in daytime energy, and the development of psychological disorders during pregnancy and the postpartum period.

Methods
The IRLSS scale was used to determine the presence of RLS symptoms. The total test sample that included the tested and control groups was (n=390) subjects. The examined group consisted of pregnant women (n=260), and the control group consisted of female students (n=130). In total, 260 pregnant women were monitored 6 months after pregnancy. Three measurements were performed, first in the third trimester of pregnancy, second two months after delivery, third 6 months after delivery, while one cross-sectional measurement was performed for the control group.

Results
The prevalence of RLS in pregnancy is highest in the third trimester and amounts to 26.5 %. In the postpartum period, a significant decrease in the prevalence of RLS was observed, measured two months after delivery (18.1 %). Postpartum, over time, a decrease in the prevalence of RLS was noticed, and six months after delivery it was (7.3 %), when it practically approached the prevalence of the control group (standard population) which was (6.2 %).

Conclusions
The prevalence of RLS is highest during the third trimester of pregnancy and decreases after delivery so that 6 months after delivery it approaches the prevalence of the standard population.
Uterine isthmic tourniquet left in situ as a new approach for placenta previa-accreta surgery: a comparative study
Authors: Bağlı İhsan , Öcal Ece , Bala Mesut , Tahaoğlu Zelal , Bakır Mehmet Sait , Halisçelik Mesut Ali , Bademkıran Cihan , Gül Erdoğan 
Published: August 2024

Abstract

Objectives
Placenta previa-accreta spectrum disorders are a cause of obstetric hemorrhage that can lead to maternal fetal mortality and morbidity. We aimed to describe the use of a uterine isthmic tourniquet left in situ as a new uterus-preserving approach for patients with placenta previa-accreta.

Methods
In this retrospective comparative study, the patients who underwent surgery for placenta previa between 2017 and 2024 at our tertiary hospital were reviewed. Primary outcome of the study is to evaluate feasibility of uterine isthmic tourniquet left in situ for uterine preserving by preventing postpartum hemorrhage for patients with placenta previa-accreta. As a secondary outcome, group 1 (n=28) patients who were managed with uterine isthmic tourniquet left in place were compared with patients in group 2 (n=32) who were managed with only bilateral uterine artery ligation.

Results
This new approach uterine isthmic tourniquet technique prevented postpartum hemorrhage with a rate of 100 percent in group 1 patients, while uterine artery ligation prevented postpartum hemorrhage with a rate of 75 % in group 2. Postoperative additional interventions (relaparotomy hysterectomy, balloon tamponade application, uterine or vaginal packing) were performed for eight patients in group 2 (25 %) but not in group 1 (0 %) (p=0.015). The haemoglobin levels before caesarean section were similar in both groups (p=0.235), while the postoperative haemoglobin levels were lower in group 2 (9.69 ± 1.37 vs. 8.15 ± 1.32) (p=0.004). Erythrocyte suspension was given to two patients in group 1 and 12 patients in group 2 (2/28 7 % vs. 12/32 37 %, p=0.018).

Conclusions
The uterine isthmic tourniquet left in situ technique is a safe, simple and effective for preventing postpartum hemorrhage and preserving uterus during placenta previa accreta surgery as superior to uterine artery ligation alone.
Season and History
Authors: Kelin LI 
Published: August 2024

Abstract
Landscape painting flourished in the late Tang dynasty and reached its peak during the Song dynasty. It means that the artistry of landscapes no longer serves as decoration for portraits, nor is it merely a backdrop for unfolding stories. Instead, it is a simple pursuit of the aesthetic pleasure derived from landscapes themselves. In this pursuit, the landscape painting of the Song dynasty had a profound impact on the subsequent development of landscape art, both in terms of form and the spiritual content expressed. It is not an exaggeration to say that Song dynasty landscape painting laid the foundation for the tradition of literati landscape painting. Guo Xi, a master of landscape painting and a painter-theorist in the mid-Northern Song period, actively explored his artistic practice. He also reflected on and summarized his methods. From the overall conception of the meaning of landscapes to the self-pursuit of brushwork style, Guo Xi endeavored to narrow the gap between abstract ideas and concrete execution. His efforts resonated with the Daoist philosophy of Neo-Confucianism in the Northern Song, transcending the dimensions of transcendental “essence” and personal “effort” to establish a connected path of nature, body, and destiny. From a different perspective, this also represents the interplay of cosmology and ontology through generative time.
Stepping-out-of-Oneself: An Intercultural Dialogue on the Power of Things
Authors: Wang Zhuofei 
Published: August 2024

Abstract
The concept stepping-out-of-oneself concerns a process by which things manifest themselves and make themselves present. This process does not depend on subjective influence but on the power of the thing itself. In this respect, the value of the thing itself and its impact on the sensory experience are brought to the foreground. From an aesthetic point of view, this concept corresponds to a new orientation of contemporary aesthetics of nature, which reflects the programmatic weakening of the subject-centered approach, the estrangement from the substance ontology as well as the phenomenological interest in the power of things.
In this article, I attempt to argue that traditional Daoist thought can also provide a point of contact for the exploration of stepping-out-of-oneself. The focus on my study is on two issues: 1. under what circumstances is stepping-out-of-oneself possible? 2. how is it possible to perceive stepping-out-of-oneself?
Cuidado transicional da pessoa idosa após Acidente Vascular Cerebral: revisão de escopo
Authors: Coêlho Wender Gonçalves , Matiello Fernanda de Brito , Bento Dieyeni Yuki Kobayasi , Mendes Karina Dal Sasso , Fernandes Daiane de Souza , Braga Pollyanna Guimaraes , Rodrigues Rosalina Aparecida Partezani 
Published: August 2024

Objetivo: mapear a transição do cuidado da pessoa idosa após acidente vascular cerebral do hospital para o domicílio. Métodos: revisão de escopo, segundo a metodologia JBI. A busca foi conduzida em oito bases de dados, uma biblioteca eletrônica, além de fontes de literatura cinzenta. O Endnote e o Rayyan foram as ferramentas utilizadas para a seleção dos estudos, seguindo as diretrizes do PRISMA-ScR. A seleção dos estudos envolveu dois revisores, com um terceiro para análise final. Resultados: de 1.378 estudos, 30 foram selecionados para leitura na íntegra, resultando em 12 artigos publicados entre 2013 e 2023, sendo três qualitativos, oito quantitativos e um estudo misto. Além disso, da literatura cinzenta foram resgatados dois capítulos de livros para compor a amostra, totalizando 14 estudos abordando o tema. Conclusão: destaca-se que as propostas de plano necessitam abranger condições gerais da pessoa idosa no processo de transição, porém deve-se atentar para o contexto ambiental em que a pessoa vive e a disponibilização de recursos. Contribuições para a prática: as evidências descritas podem auxiliar a construção de medidas mais efetivas para o aprimoramento da assistência prestada a esse indivíduo que necessita transicionar seus cuidados do hospital para o domicílio.
Analysis of the Potential and Performance of the Tourism Sector towards the Community (Study on Pasir Kencana Beach Tourism Area in Pekalongan City)
Authors: Syakira Elsa 
Published: August 2024

Purpose: Tourism has become a major growth engine in Indonesia and has helped the local economy and government. One of Indonesia's emerging economic sectors is tourism. Pekalongan is one of the most central cities in Java and has many natural and man-made tourist spots. To increase the attractiveness and sustain tourism, Pasir Kencana tourism in Pekalongan city should be properly managed. The objective of this investigation is to determine the extent to which community-based tourism (CBT) is being used, how it is implemented, and what obstacles are encountered in implementing CBT in tourism.
Method: Data were collected through observations, interviews, and documentation. Data analysis was conducted through the use of the descriptive narrative method.
Result: These results show that although the community has participated in tourism management, it has not reached the desired level. Pasir Kencana Beach is a good example of community-based tourism, evidenced by the activities of a good tourism outreach group (Pokdarwis). Constraints of community-based tourism management development strategies include promoting tourism, adding qualified human resources based on the field of education, using information technology to introduce and promote tourism to a wider audience; it is also possible to attract investors to help improve tourism-related infrastructure and develop tourism destinations by making the best use of available space and leveraging local uniqueness and culture to generate more revenue from visitors.
Contribution: This research contributes to developing scientific concepts about community participation in developing tourist destinations.
What Do Oil Rig Trainees Think About How Drilling Simulations Affect their Motivation and Ability to Learn?
Authors: Abdelaziz Adel M. H. 
Published: August 2024

Abstract
The lack of sufficient enrollment in vocational drilling training programs has led to a shortage of skilled workers, resulting in difficulties in recruiting and retaining national crews for drilling rigs. Utilizing state-of-the-art simulation technology will enhance the rig crew and trainees’ productivity, educational progress, motivation, and accomplishments. A basic qualitative study investigated the impact of simulation technologies on trainees’ learning, motivation, and viewpoints regarding their education at the vocational training facility for oil-field drilling rigs. The conceptual framework for user reception of information systems was based on Davis's technology acceptance model. Ten drilling crew trainees were selected for semistructured virtual interviews. Subsequently, the data was transcribed, and a manual process of descriptive coding was employed to discover five themes that directly addressed the research topics. Five distinct patterns were identified via the process of analyzing the data. The initial three themes encompassed the simplicity and practicality of teaching drilling application skills through simulator technology. The next two themes were the manner in which the use of the drilling simulator motivated and instilled a sense of enthusiasm in the trainees, hence fostering their inclination to conclude their studies successfully. The study's results demonstrated that using drilling simulators in training proved highly advantageous. It facilitated the establishment of a practical training setting that was secure, economically efficient, and user-friendly. The training familiarized the trainees with the operation and handling of various rig equipment and tools. It enhanced the trainee's drilling and well control skills, increasing their working experience. Additionally, it facilitated the trainees’ experience of challenging scenarios related to different operations and fostered a sense of teamwork. This contributed to a decrease in the rig's non-productive time. The study's findings could provide valuable insights to executives of drilling contractor training facilities regarding the significance of expanding drilling simulation methods to encompass all potential drilling job activities. Drilling simulators can foster beneficial societal transformation among trainees, the drilling rig personnel, and the regional community by enhancing their knowledge and comprehension of drilling procedures.
Context-Aware Workflow Model Based PolymorphicWheelchairLocomotoryfor Physically Challenged
Authors: P Karthikeyen , S Geetha , D Mugundhan , BM Somesh , B Rahul 
Published: August 2024

Abstract

This groundbreaking project revolves around revolutionizing mobility for individuals with locomotory disabilities through an advanced wheelchair system. The core innovation involves a specialized device with voice recognition technology, eliminating the need for traditional joysticks and enabling users to effortlessly maneuver their wheelchairs with vocal commands. The system extends its functionality to navigate both confined spaces and familiar locations, utilizing user provided layouts for seamless movement. Safety is paramount, with an obstacle detection sensor halting the wheelchair and triggering an alarm in the presence of obstructions. Real-time tracking ensures the user's locationis knownto caregivers, and an automatic alert system activates in case of accidents, enhancing overall safety and independence. This comprehensive solution integrates cutting-edge technologies to empowerindividuals with mobility challenges, addressing a critical need inthe community.