bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of culture results and composition of microbiome of removed tonsils due to distant focal disease or other reasons. A prospective pilot study
Authors: Bella Zsolt , Erdélyi Eszter , Kiricsi Ágnes , Gaál Veronika , Lázár Andrea , Maróti Gergely , Wirth Roland , Sóki József , Nagy Elisabeth 
Published: June 2024

AbstractThe aim of this prospective pilot study was to compare culture and microbiome results of the removed tonsils of patients with assumed distant focal disease (11 patients) and those who underwent a tonsillectomy, due to other reasons, such as recurrent tonsillitis, tonsil stones or snoring (nine patients). Aerobic culture was carried out for samples taken from the surface of the tonsils by swabs before tonsillectomy for all 20 patients. The squeezed detritus and the tissue samples of removed tonsils, taken separately for the right and left tonsils, were incubated aerobically and anaerobically. The microbiome composition of tissue samples of removed tonsils was also evaluated. Based on the culture results of the deep samples Staphylococcus aureus was the dominating pathogen, besides a great variety of anaerobic and facultative anaerobic bacteria present in the oral microbiota in those patients who underwent tonsillectomy due to distant focal diseases. Microbiome study of the core tissue samples showed a great diversity on genus and species level among patients of the two groups however, S. aureus and Prevotella nigrescens were present in higher proportion in those, whose tonsils were removed due to distant focal diseases. Our results may support previous findings about the possible triggering role of S. aureus and P. nigrescens leading to distant focal diseases. Samples taken by squeezing the tonsils could give more information about the possible pathogenic/triggering bacteria than the surface samples cultured only aerobically.
Digitalization of Islamic Philanthropy: Development of a Philanthropic Da'wah Model rumahzakat.org
Authors: Hamdani Amin , Aziz Malik Akbar Abdul 
Published: June 2024

This research investigates the development of the rumahzakat.org philanthropic da'wah model and developing activities in the digital world. This study aims to explore, study and discover the philanthropic da'wah model developed by rumahzakat.org. This research was conducted using a qualitative approach and a case study. His research processes include observations, in-depth interviews, examination of digital and manual documents, and data analysis. This research found that the rumahzakat.org institution uses the da'wah bil hal or da'wah amali model to encourage people to carry out various charitable activities. This institution manages zakat, infaq, shadaqah, and other social funds to promote community empowerment activities based on love for others. Apart from that, the results show that philanthropic da'wah activities using new media are da'wah activities that build relationships with the media in the form of consolidation, namely mutual benefit for each other's goals. Finally, the results show that rumahzakat.org can carry out digital-based philanthropic da'wah activities to adapt da'wah activities to current developments, make program services more accessible, and make services available transparently to everyone. To develop a transformative da'wah model, da'wah based on digital philanthropy must be improved.
Clinical experience in the neoadjuvant treatment of unresectable differentiated thyroid cancer with the lenvatinib
Authors: Vasilyeva E. B. , Rostovtsev D. M. , Tolpeikina К. A. , Fatkullin D. M. , Guz A. О. 
Published: June 2024

Introduction. In some cases of differentiated thyroid cancer expansion into the main vessels and adjacent organs, surgical intervention is impossible. Not many cases of successful use of targeted therapy as neoadjuvant regimen to treat nonresectable differentiated thyroid cancer were reported, but this approach can be an option in management of such patients.Aim. To analyze clinical experience of using lenvatinib as neoadjuvant therapy in patients with primary nonresectable differentiated thyroid cancer.Materials and methods. Retrospective analysis of treatment of 7 patients with primary nonresectable differentiated thyroid cancer with lenvatinib as neoadjuvant therapy at Chelyabinsk Regional Clinical Center for Oncology and Nuclear medicine between 2021 and 2023 was performed.Results. Treatment response was evaluated in 4 (71.4 %) patients. In 2 (50 %) patients, partial response was observed, in 2 - stable disease. Radical surgical intervention became possible in 2 patients. The other 2 patients could not undergo surgery: in 1 patients time to progression was 17.8 months, therapy was changed to the 2nd line drug cabozantinib; 1 female patient with best response (partial) currently continues lenvatinib treatment, tumor is nonresectable, duration of drug administration is 8.9 months.Conclusion. Our experience of using lenvatinib in patients with nonresectable differentiated thyroid cancer shows that this therapy can be successfully used as neoadjuvant treatment in this patient group.
Surgical treatment of patients with multiple brain metastases
Authors: Belov D. M. , Karakhan V. B. , Bekyashev A. Kh. , Mitrofanov E. V. , Prozorenko E. V. , Aleshin V. A. , Sufianov R. A. , Nashletashvili D. R. 
Published: June 2024

Introduction. The standard of treatment for patients with single cerebral metastases is surgery and radiosurgery. The use of these methods significantly increases survival rates.Aim. To compare the results of surgical treatment of patients with single and multiple cerebral metastases.Materials and methods. The study included 40 patients with single and multiple cerebral metastases who underwent neurosurgical intervention in the neuro-oncology department of the N.N. Blokhin National Medical Oncology Research Center from 2010 to 2022.Results. All patients are divided into 3 groups. Group A included 15 patients who removed all available cerebral foci (from 2 to 4). Group B included 10 patients with multiple cerebral metastases who underwent removal of one symptomatic metastasis. In group C, 15 patients who underwent removal of a single metastasis. It was noted that the survival of patients after removal of all cerebral metastases is identical to the survival of patients after removal of single metastasis 11.9 and 12.4 months, respectively. And it was significantly higher than the survival of patients who removed not all cerebral metastases 6.2 months (p = 0.03). Also in group A and C, the percentage of local relapses was identical. Improvement in neurological status was noted in all groups, there was only an increase in cognitive-mnestic disorders in group A, where all cerebral foci were removed. However, these disorders were moderate and did not reach the extent of dementia. The work done shows.Conclusion. Surgical removal of all metastases in patients with multiple brain metastases provides a prognosis similar to that of patients undergoing surgery for single metastasis. Removal of symptomatic metastasis in patients with multiple cerebral lesions in most cases leads to a regression of neurological symptoms and makes it possible to continue treatment with a group of patients whose condition was considered incurable. The percentage of local relapses in the removal of multiple cerebral metastases, subject to oncological principles, is the same as in the removal of single metastases.
Guidelines for radioiodine therapy in differentiated thyroid cancer and post-therapeutic follow-up
Authors: Shurinov A. Yu. , Borodavina E. V. , Krylov V. V. , Sigov M. A. , Rodichev A. A. , Ivanov S. A. , Kaprin A. D. 
Published: June 2024

The radioiodine therapy is a one of the basic elements at combined treatment of differentiated thyroid cancer and is an alternative method for patients with distant metastases and a potentially high risk of tumor recurrence. It has been used in clinical practice for more than 80 years. The first report on the phenomenon of accumulation of 130I/131I in a metastatic focus of differentiated thyroid cancer was published by A. Keston et al. in 1942, and in 1946, the production of 131I was established, and the drug became available. In our country, radioiodine therapy has been widely used for the treatment of differentiated thyroid cancer since 1982.This article presents methodological recommendations for radioiodine therapy of patients with differentiated thyroid cancer, provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches treatment of this disease.
Quality of life in menopausal women attending gynaecology OPD in a tertiary care hospital
Authors: Agrawal Deepika , Sharma Manisha , Popli Sangeeta 
Published: June 2024

Background: The longevity of women due to increase in life expectancy makes them spend almost one third of life after menopause. Menopause is a transitional event that can profoundly affect quality of life. It is an adaptation process accompanied by many biological, psychological changes. Aim of the study was to study menopause related symptoms, their severity and impact on quality of life.
Methods: The longevity of women due to increase in life expectancy makes them spend almost one third of life after menopause. Menopause is a transitional event that can profoundly affect quality of life. It is an adaptation process accompanied by many biological, psychological changes. Aim of the study was to study menopause related symptoms, their severity and impact on quality of life.
Results: The present study showed that the most severe symptoms of vasomotor, psychological, physical and sexual domains were hot flushes, night sweats, feeling of wanting to be alone, feeling depressed, low backache, change in sexual desire. In group 1 there were more vasomotor symptoms as compared to group 2. Severity of psychological, physical, sexual symptoms increased in group 2. In local gynaecological examination more abnormalities were found in group 2 (34%) as compared to group 1 (14%). Also, there was an increased percentage of diabetes (18.96%), hypercholesterolemia (31.03%), hypertriglyceridemia (31.03%) in group 2.
Conclusions: Our study concluded that by identifying characteristics associated with poor quality of life of menopausal women would help them in making strategies that are required for improving their health and quality of life.
Post operative wound infection: a descriptive study
Authors: Kallakuri Kavitha , Suprada K. , Bahadur B. Rao , Rao Gangadhar 
Published: June 2024

Background: Surgical site infections is the third most commonly reported nosocomial infection which has an adverse impact on the hospital as well as the patient. This study was designed to evaluate the frequency, clinical presentation, common risk factors and different organisms involved.
Methods: This study was performed at NRI Medical college, Chinnakakani. This is an Observational descriptive study over a period of one year from September 2022 to September 2023. Biodata of the patients together with their clinical features, diagnosis, type of surgery performed and the development of any complications including wound infection was noted and the data analyzed.
Results: Out of 1509 patients in the study, 1101 belonged to obstetrics and 408 to gynaecology surgery. The overall incidence of surgical site infection in the study was 7.9%; 86 (7.8%) in obstetrics group and 33 (8%) in gynaecology group developed infection. Age more than 50 years was found to be a risk factor for postoperative wound infection. Obesity is known to be a well-established risk factor for postoperative wound infection. It was noted that surgical site infection was more common in patients that had low haemoglobin levels pre-operatively. The increased susceptibility to infection in diabetics is an established risk factor.
Conclusions: Meticulous surgical technique, proper sterilization, judicious use of antibiotics, improvement of ward environments, control of malnutrition and obesity, treatment of infective foci and diseases like diabetes helps control the morbidity of surgical wound infections.
Prospective comparative study of use of diclofenac suppository (150 mg) and intramuscular diclofenac (75 mg) for pain management of patients in post-operative laparoscopic cholecystectomy
Authors: Naz Alquama , Haque Imdadul , Roy Prasanto Kumar , Devangan Komal Prasad 
Published: June 2024

Background: Laparoscopic cholecystectomy is a gold standard surgical procedure for treatment of gallstone disease. Early postoperative pain management will lead to early ambulation, early recovery. This study will help us to make a conclusion whether to use rectal suppositories of NSAIDS as effective alternative to intramuscular injection of NSAIDS for postoperative pain management and recovery of the patients in laparoscopic cholecystectomy. Rationale of this study is to check the effectiveness of Diclofenac rectal suppositories on postoperative patients for pain and morbidity.
Methods: Study was conducted in 50 patients. Diclofenac 150mg suppository (one and half) introduced per rectally at the time of induction of anaesthesia in 25 patients and in another group, 75 mg diclofenac injection given intramuscularly at the time of induction of anaesthesia in another 25 patients. Only single dose of diclofenac administered. For any pain complaints (VAS >3), a dose of intravenous paracetamol 1 gram was given SOS with minimum interval of 6 hours in both group. Readings was taken at an interval of 6, 12 and 24 hours postoperatively.
Results: There is significant reduction in postoperative pain in group A compare to group B according to VAS with significant p value (0.005 in 6 hours, <0.001 in 12 hours and <0.001 in 24 hours postoperatively). % of decrease in VAS is more in group A with p value 0.001 in 12 hours and 0.004 in 24 hours postoperatively.
Conclusions: In conclusion per rectal suppository of diclofenac for Laparoscopic cholecystectomy reduces pain in the initial postoperative period, it is easy to administer with no adverse effects and may become routine practice for this procedure. This simple, safe, inexpensive, effective form of diclofenac thus improve postoperative analgesia in hospital course. We advocate its use in all elective laparoscopic cholecystectomies.
Arystoteles, Tomasz z Akwinu, Jan Duns Szkot: Kilka uwag o różnicy między starożytnym i średniowiecznym pojmowaniem cnoty
Authors: Koszkało Martyna 
Published: June 2024

Artykuł przedstawia grecki ideał człowieka cnotliwego prezentowany w koncepcji Arystotelesa w kontraście do odpowiednika tego ideału obecnego w kulturze chrześcijańskiej (Tomasz z Akwinu, Jan Duns Szkot). Pewne elementy etyki Arystotelesa wzbudzały bowiem kontrowersje, szczególnie elitaryzm oraz model megalópsychos i musiały zostać w etyce chrześcijańskiej przekształcone. Ze względu na nowy model antropologiczny (człowieka jako istoty grzesznej) pojęcie cnoty uległo pewnej modyfikacji zwłaszcza w nurtach woluntarystycznych, gdyż cnotliwy człowiek, mimo posiadania dobrego charakteru, jest w ramach takiej wizji podatny na upadek. Artykuł prezentuje koncepcję relacji przyczynowej między cnotą a wolną wolą, odnosząc się do uwag Tomasza z Akwinu i Jana Dunsa Szkota. Ponieważ nie ma miejsca na libertariańsko pojętą wolną wolę w etyce Arystotelesa jego cnotliwy ideał moralny jest w pewnym sensie ideałem zamkniętym w swojej doskonałości. Różnica pomiędzy perspektywą chrześcijańskiej i greckiej etyki polega na tym, że w etyce chrześcijańskiej podmiotowość realizuje się bardziej w wolnych aktach podmiotu niż w praktycznej racjonalności. Tym samym cnota nie może determinować wolnej woli w sposób, który odbierałby woli liberatriańsko pojętą wolność.
La enseñanza transversal de la lectura y la escritura en la Escuela Media
Authors: Scalia Liliana 
Published: June 2024

El presente ensayo intenta demostrar la necesidad de pensar la enseñanza de la lectura y de la escritura como un proceso complejo que involucra múltiples dimensiones: lingüística, paralingüística, discursiva, cultural, ideológica y psicológica. Por esta razón, la tarea de dar la palabra a otros para que se la apropien no es una función exclusiva del docente de Lengua, sino que se convierte en la función fundamental de todos los docentes de la Escuela de Nivel Medio hoy (Según Sistema Educativo de la República Argentina- Obligatorio - desde los 12 a los 18 años). Considero que asumir la transversalidad de la enseñanza de la lecto-escritura en una institución educativa permitirá acompañar y estimular el desarrollo de las competencias comunicativas de los jóvenes estudiantes.
Docentes y estudiantes migrantes venezolanos: Experiencias de escolarización en Educación General Básica-Guayaquil, Ecuador
Authors: Uribe Lotero Claudia Patricia , Merchan Naranjo Jose Daniel , Matamoros Pérez María Gabriela , Ojeda Garcés Alejandro , Balda Herrera Doménica 
Published: June 2024

El estudio describe las experiencias de docentes de Educación General Básica de Guayaquil con la escolarización de estudiantes venezolanos en situación de movilidad humana durante los años 2018 a 2021. El enfoque cualitativo del estudio indagó en las experiencias docentes, las condiciones socioeducativas y circunstancias de permanencia o abandono escolar de los estudiantes migrantes venezolanos. Once docentes mujeres participaron de un taller reflexivo y entrevistas narrativas. Las experiencias de las docentes se caracterizan por emociones de preocupación y prácticas de cuidado afectivo a los estudiantes, tras constatar las dificultades que para ellos implica su condición de movilidad humana al momento de insertarse en el proceso de escolarización. Las relaciones de las docentes con las familias se centran en el apoyo que ellas proporcionan a las actividades escolares de los estudiantes. Las docentes resaltan aprendizajes adquiridos a partir de la capacidad de resiliencia de los estudiantes frente a las adversidades.
The Effect of Walking Exercise Program for Reducing Fatigue in Cancer Patients Undergoing Medical Treatment
Authors: Sulistyarini Wahyu Dewi , Alvianty Yanda Savira 
Published: June 2024

Cancer is one of the most serious problems in the world and Indonesia because the number of sufferers continues to increase. The most common symptom felt by cancer patients undergoing treatment is fatigue. Fatigue management consists of pharmacological and non-pharmacological. Physical activity, such as walking exercise programs, is a therapeutic option for reducing cancer-related fatigue (CRF). This study aimed to determine the effect of applying a walking exercise program on the level of fatigue in cancer patients undergoing treatment. This study used a time series method without a control group design. The respondents were 13, and the criteria were cancer patients undergoing treatment. The instrument uses the Brief Fatigue Scale- Indonesian version. The implementation of the Walking Exercise Program (WEP) in the first week of the patient's fatigue score was 39.77; the results of the second-week application score was 20.31, and the application given in the third week dropped to 14.46. The results of the Greenhouse-Geyser test have a significance value of 0.03<0.05, then Ho is rejected, and Ha is accepted. Applying the Walking Exercise Program (WEP) reduces fatigue in cancer patients undergoing treatment.
Pemanfaatan Modal Budaya dalam Mendukung Pariwisata Edukasi di Desa Wisata Pentingsari
Authors: Aji Riswandha Risang 
Published: June 2024

<p><em>P<em><span lang="IN">Pariwisata di Indonesia memiliki banyak jenis atraksi. Salah satu yang menjadi atraksi adalah modal budaya. Modal budaya di Indonesia sering dimanfaatkan untuk menjadi atraksi pariwisata terutama di daerah-daerah yang memiliki budaya khas. Desa </span><span lang="FI">Wisata </span><span lang="IN">Pentingsari adalah satu satu daerah dengan karak</span><span lang="FI">t</span><span lang="IN">eristik tersebut. Desa Wisata Pentingsari menerapkan pariwisata edukasi dalam kegiatan pariwisatanya. Tujuan dari penelitian ini adalah melakukan analisis terkait dengan pemanfaatan modal budaya di Desa Wisata Pentingsari untuk mendukung pariwisata edukasi di desa tersebut. Penelitian ini menggunakan pendekatan kualitatif dengan metode pengumpulan data berupa observasi dan wawancara. Hasil dari penelitian ini menunjukkan Desa Wisata Pentingsari memanfaatkan modal budaya yang dimilikinya untuk pengembangan pariwisata edukasi berupa gamelan dan obat herbal tradisional. Kesimpulan dari penelitian ini adalah </span><span lang="FI">D</span><span lang="IN">esa </span><span lang="FI">W</span><span lang="IN">isata Pentingsari memanfaatkan modal budayanya untuk pengembangan pariwisata edukasi. </span><span lang="FI">S</span><span lang="IN">elain itu </span><span lang="FI">D</span><span lang="IN">esa </span><span lang="FI">W</span><span lang="IN">isata Pentingsari juga bertujuan untuk melestarikan modal budayanya.</span></em></em></p>
Analisis Interaksi Spasial Antarwilayah di Kabupaten Sidoarjo: Identifikasi Pusat Pertumbuhan Ekonomi dan Dampaknya terhadap Ketimpangan
Authors: Rohmah Nur Afiyatur , Fitrianto Achmad Room 
Published: June 2024

<p><em><span lang="IN">Daerah dengan tingkat fasilitas tinggi akan mampu mendorong pembangunan dan pertumbuhan ekonomi wilayahnya menjadi lebih baik. Di sisi lain, daerah dengan tingkat fasilitas yang kurang memadai akan lebih banyak berinteraksi dengan wilayah lain untuk mencukupi kebutuhannya. Apabila kemampuan daerah dalam hal interaksi tersebut lemah, maka akan terjadi ketimpangan daerah. Penelitian ini bertujuan untuk menganalisis interaksi spasial antarkecamatan di Kabupaten Sidoarjo dan mengidentifikasi kecamatan yang potensial sebagai pusat pertumbuhan ekonomi. Data yang digunakan adalah data sekunder dari Badan Pusat Statistik Kabupaten Sidoarjo tahun 2021. Metode Skalogram dan Indeks Sentralitas digunakan untuk mengidentifikasi kecamatan yang potensial sebagai pusat pertumbuhan ekonomi. Hasilnya menunjukkan bahwa kecamatan dengan fasilitas publik yang lebih baik cenderung memiliki nilai sentralitas yang lebih tinggi, dan beberapa kecamatan di utara Kabupaten Sidoarjo memiliki potensi lebih besar sebagai pusat pertumbuhan ekonomi. Hasil analisis menunjukkan bahwa terdapat beberapa faktor yang mempengaruhi pertumbuhan wilayah perkotaan, diantaranya termasuk faktor lokasi dan pertumbuhan penduduk. Studi menunjukkan bahwa kenaikan jumlah penduduk dapat mempengaruhi pendapatan daerah dan pertumbuhan ekonomi di suatu wilayah, meskipun dampaknya dapat berbeda-beda tergantung pada kondisi lokal. Kabupaten Sidoarjo sebagai wilayah peri-urban mengalami pertumbuhan ekonomi yang didorong oleh efek pertumbuhan ekonomi dari wilayah sekitarnya yang disebut spread effect. Meskipun demikian, peningkatan perekonomian juga dapat menyebabkan ketimpangan ekonomi yang tercermin dalam peningkatan Rasio Gini.</span></em></p><p> </p>