bluuebunny/crossref_metadata_2025_split huggingface dataset:
The bright side of cross ownership: Evidence from the corporate resilience to COVID‐19 crisis in China
Authors: Chen Yihui , He Xin , Wei Haoyuan 
Published: August 2024

AbstractWe investigate the impact of cross ownership on corporate resilience around the COVID‐19 pandemic in the Chinese financial market. We show that firms with greater cross ownership experience higher corporate resilience, evidenced by a milder reduction in revenue during the COVID‐19 pandemic and a faster recovery in revenue afterwards. This effect is more pronounced for firms in high‐tech industries and large firms, firms in regions severely hit by the pandemic, and regions with better commercial credit environments. We argue that cross ownership improves the financing resources, corporate governance, and information acquisition, which enhances corporate resilience in the presence of the pandemic. Consistent with this notion, we find that firms with greater cross ownership have higher financing flexibility, fewer agency problems, and less information asymmetry during the COVID‐19 pandemic.
What influences the implementation of clinical guidelines related to enteral nutrition in the intensive care unit: A mixed‐methods systematic review
Authors: Li Jia Qi , Sun Ting , Zuo Jun Tao , Xu Yao , Cai Li Na , Zheng Heng Yu , Ye Xiang Hong 
Published: August 2024

AbstractAimsTo systematically evaluate and analyse literature concerning the factors influencing the implementation of clinical practice guidelines related to enteral nutrition in the adult intensive care unit.BackgroundGuidelines serve as crucial tools for guiding clinical practice. However, a significant gap persists between current clinical practice and guidelines pertaining to enteral nutrition. It is essential to identify the reasons behind this disparity to foster clinical transformation.MethodsA mixed‐methods systematic review.Data SourcesA systematic search was conducted across PubMed, Embase, Medline, Cochrane, PsycINFO and CNKI databases to identify impediments and facilitators to the implementation of ICU clinical practice guidelines related to enteral nutrition. The types of studies included quantitative, qualitative and mixed‐methods studies. The search spanned from January 2003 to January 2024 and was updated in May 2024. The quality assessment of the included literature was conducted using the Mixed‐Methods Study Evaluation Tool (MMAT). Data analysis was performed using a data‐based convergent integration approach. The protocol for this study was prospectively registered (PROSPERO2023, CRD42023483287).ResultsTwenty papers were finally included, and 65 findings were extracted, integrating a total of three categories, Category 1: healthcare provider factors, including three sub‐themes: knowledge of guideline‐related knowledge and awareness of guideline application; social/professional roles and identity domains; beliefs, attitudes and self‐efficacy; collaboration, Category 2: practice environments, including two sub‐themes: environmental factors and resource areas; systems and behavioural norms, Category 3: patient values and nutritional support preferences including two sub‐themes: patient disease status and value orientation.ConclusionHealthcare professionals should analyse obstacles and facilitators to guideline implementation from multiple perspectives, strengthen healthcare collaboration, improve education and training systems, correct misperceptions and increase awareness of evidence‐based practice.
Outcomes of hybrid surgical ablation and concomitant left atrial appendage exclusion in long‐standing persistent atrial fibrillation
Authors: Ahmed Adnan , Ghazal Rachad , Bawa Danish , Darden Douglas , Koerber Scott , Chilappa Rishit , Kabra Rajesh , Meeteren Justin Van , Romeya Ahmed , Gopinathannair Rakesh , Lakkireddy Dhanunjaya , Pothineni Naga Venkata K. 
Published: August 2024

AbstractIntroductionManagement of patients with long‐standing persistent atrial fibrillation (LSPAF) presents a clinical challenge. Hybrid convergent ablation has been shown to have superior efficacy compared to endocardial‐only ablation. However, data on concomitant left atrial appendage (LAA) management along with hybrid ablation is sparse.MethodsWe aimed to evaluate the effectiveness of concomitant hybrid convergent ablation and LAA clipping in patients with LSPAF. We conducted a retrospective analysis of all patients with LSPAF who underwent hybrid surgical ablation with LAA clipping at our institution. The primary endpoint was a recurrence of atrial arrhythmias at 12 months. Further, the durability of surgical left atrial posterior wall ablation was examined during the endocardial catheter ablation using standing electrophysiological criteria.ResultsA total of 79 patients were included. Mean age was 63.5 ± 9.6 years, and 71% were males. LAA clipping was performed in 99% of patients. The mean time between the surgical and endocardial stages of the procedure was 2.6 ± 1.7 months. Persistent posterior wall activity was observed in 34.2% (n = 27/79) patients during the endocardial phase of the procedure. Cardiac implantable electronic device was used in 74% of patients for monitoring of recurrence of atrial fibrillation (AF). The primary effectiveness of AF freedom at 12 months was 73.8% (45/61). Over a 12‐month follow‐up period, 11.4% (9/79) of patients required repeat catheter ablation, of which 88.9% (8/9) had evidence of persistent posterior wall activity.ConclusionConcomitant hybrid convergent ablation and LAA exclusion with an atrial clip provides reasonable long‐term AF‐free survival in patients with LSPAF. Persistent posterior wall activity is seen commonly in patients presenting with recurrent AF following hybrid convergent AF ablation.
CKIP‐1 silencing suppresses OSCC via mitochondrial homeostasis‐associated TFAM/cGAS‐STING signalling axis
Authors: Xie Ji‐Rong , Chen Xiao‐Jie , Zhou Gang 
Published: August 2024

AbstractLimited effective targets have challenged the treatment of oral squamous cell carcinoma (OSCC). Casein kinase 2 interacting protein 1 (CKIP‐1) is a scaffold protein involved in various diseases. However, the role of CKIP‐1 in OSCC remains unclear. The aim of this study was to explore the regulatory role of CKIP‐1 in OSCC, as well as the involved mechanism. First, higher expression of CKIP‐1 in OSCC tissues and cell lines were found. Series of gain‐ and loss‐of‐function experiments demonstrated suppressed malignant behaviours and enhanced apoptosis of OSCC cells when CKIP‐1 was silenced. Also, inhibited tumour growth in CKIP‐1‐silenced group were proved. Further, mitochondrial transcription factor A (TFAM) downregulation, increased ROS production, decreased mitochondrial membrane potential and cGAS‐STING activation in CKIP‐1‐silenced group were observed. The involvement of mitochondrial homeostasis‐related TFAM/cGAS‐STING axis in CKIP‐1‐silenced OSCC cells was finally demonstrated by tetramethylpyrazine (TMP) that inhibits TFAM degradation. Taken together, our study demonstrated that CKIP‐1 silencing could significantly antagonize OSCC via TFAM/cGAS‐STING axis, which may provide a candidate target for OSCC treatment.
Application of the integrated data platform combined with dietary management for adults with diabetes: A prospective randomized controlled trial
Authors: Liu Xiyu , Wang Xiaohong , Xie Mengxun , Cao Lulu 
Published: August 2024

AbstractAimsTo investigate the efficacy of the integrated data platform of cloud hospital combined with dietary management for adults with type 2 diabetes.Materials and MethodsWe conducted a randomized controlled clinical trial. One hundred eighty patients with type 2 diabetes were randomly allocated into a control group (Group A) and an experimental group (Group B). Routine standard diabetes care was applied to the patients in Group A. The integrated data platform with dietary management was applied to Group B. Individualized diabetes education videos were sent to the patients through the platform. The primary endpoint was the change in HbA1c and change in body weight from baseline to Week 12 during the follow‐up.ResultsAt Week 12, HbA1c was 7.4 ± 0.7%, 6.9 ± 0.9% in Groups A and B, P < 0.01. The rate of fasting blood glucose <7 mmol/L, and glycosylated hemoglobin <7% was higher in Group B than in Group A. At Week 12, there was a significant weight loss and body mass index decrease in the overweight or obese patients of the experimental group. Those overweight or obese patients in the experimental group utilizing the appetite suppressant semaglutide achieved the most significant weight loss, with a 13.4% reduction after 12 weeks.ConclusionsThe integrated data platform combined with personalized diabetes education video delivery was verified to be a more effective management mode for diabetes. For overweight or obese adults with diabetes, the use of semaglutide in conjunction with dietary management and the integrated data platform led to greater weight loss.
Relationship between glycaemic control and frailty in older Chinese patients: The mediating role of diabetes distress
Authors: Li Chenyang , Sun Lili , Zhu Jing , Wang Xin , Liang Shiyu , Li Nuo , Shao Lewen 
Published: August 2024

AbstractPurposeThis study aimed to investigate the effects of glycaemic control and diabetes distress on frailty in older Chinese patients with diabetes, and to explore the mediating role of diabetes distress between glycaemic control and frailty.DesignThis is a descriptive, cross‐sectional study. A total of 209 older patients with diabetes were recruited from a teaching hospital in Zhejiang Province. Data were collected from February to September 2022.MethodsA self‐designed questionnaire was used to collect demographic and disease‐related data. The Fried Scale and Diabetes Distress Scale were employed to assess frailty and diabetes distress, respectively The bootstrap method was used to examine the mediating effects of diabetes distress on glycaemic control and frailty. The STROBE checklist was adhered to in the reporting of this study (see details in File ).ResultsThe findings indicated a positive correlation between the level of glycaemic control and frailty, as well as between diabetes distress and frailty. Furthermore, diabetes distress was found to play a complete mediating role between glycaemic control and frailty.ConclusionsThe study findings highlight the relationship between glycaemic control, diabetes distress and frailty offering a valuable reference for enhancing the management of frailty in older patients with diabetes.Relevance to Clinical PracticeThis study emphasizes the significance of managing glycaemic control and diabetes distress in older patients with diabetes to prevent frailty, and may contribute for healthcare professionals to developing effective measures to improve the frailty of older diabetic patients in clinical settings.Patient or Public ContributionThis study was conducted with the participation of older patients with diabetes who contributed data by completing study questionnaires and undergoing physical assessments.
Exploring Effective Intervention Strategies for Depression as a Complex System: Targeted Interventions Through Network Simulations
Authors: Omizu Takumi , Kunisato Yoshihiko 
Published: August 2024

AbstractWe conducted mathematical simulations to identify effective treatment options for depression. These simulations involved treatment component nodes that targeted specific symptoms within the depressive symptom network, examining how interventions for certain symptoms could improve the overall symptomatology. The results indicate that targeting a symptom with higher centrality can lead to significant improvement. Furthermore, while interventions targeting symptoms with the lowest centrality did not show any improvement, targeting multiple lower‐centrality symptoms simultaneously may lead to an improvement in overall symptomatology. Insights from these simulations are expected to advance the understanding of effective intervention strategies for depression and the application of psychological networks in clinical settings.
Lymphotoxin beta‐activated LTBR/NIK/RELB axis drives proliferation in cholangiocarcinoma
Authors: Xu Kaiyu , Kessler Annika , Nichetti Federico , Hoffmeister‐Wittmann Paula , Scherr Anna‐Lena , Nader Luisa , Kelmendi Eblina , Schmitt Nathalie , Schwab Maximilian , García‐Beccaria María , Sobol Benjamin , Nieto Osama Azzam , Isele Hanna , Gärtner Ulrike , Vaquero‐Siguero Nuria , Volk Julia , Korell Felix , Mock Andreas , Heide Danijela , Ramadori Pierluigi , Lenoir Bénédicte , Albrecht Thomas , Hüllein Jennifer , Jäger Dirk , Fröhling Stefan , Springfeld Christoph , Jackstadt Rene , Heikenwälder Mathias , Dill Michael T. , Roessler Stephanie , Goeppert Benjamin , Köhler Bruno C. 
Published: August 2024

AbstractBackground and AimsCholangiocarcinoma (CCA) is an aggressive malignancy arising from the intrahepatic (iCCA) or extrahepatic (eCCA) bile ducts with poor prognosis and limited treatment options. Prior evidence highlighted a significant contribution of the non‐canonical NF‐κB signalling pathway in initiation and aggressiveness of different tumour types. Lymphotoxin‐β (LTβ) stimulates the NF‐κB‐inducing kinase (NIK), resulting in the activation of the transcription factor RelB. However, the functional contribution of the non‐canonical NF‐κB signalling pathway via the LTβ/NIK/RelB axis in CCA carcinogenesis and progression has not been established.MethodsHuman CCA‐derived cell lines and organoids were examined to determine the expression of NF‐κB pathway components upon activation or inhibition. Proliferation and cell death were analysed using real‐time impedance measurement and flow cytometry. Immunoblot, qRT‐PCR, RNA sequencing and in situ hybridization were employed to analyse gene and protein expression. Four in vivo models of iCCA were used to probe the activation and regulation of the non‐canonical NF‐κB pathway.ResultsExposure to LTα1/β2 activates the LTβ/NIK/RelB axis and promotes proliferation in CCA. Inhibition of NIK with the small molecule inhibitor B022 efficiently suppresses RelB expression in patient‐derived CCA organoids and nuclear co‐translocation of RelB and p52 stimulated by LTα1/β2 in CCA cell lines. In murine CCA, RelB expression is significantly increased and LTβ is the predominant ligand of the non‐canonical NF‐κB signalling pathway.ConclusionsOur study confirms that the non‐canonical NF‐κB axis LTβ/NIK/RelB drives cholangiocarcinogenesis and represents a candidate therapeutic target.
Isolation and comparative analysis of culturable bacterial communities associated with life stages, breeding and rearing substrates of Culicoides oxystomaKieffer (Diptera: Ceratopogonidae) vector of bluetongue virus
Authors: Sarkar Ankita , Banerjee Paramita , Mazumdar Abhijit 
Published: August 2024

AbstractCulicoides oxystoma Kieffer (Diptera: Ceratopogonidae) has been vectoring several arboviruses, protozoa and nematodes, leading to mortality and morbidity of livestock and wild ruminants in the tropics and subtropics. Insight into the bacterial communities associated with the vector species must be worked out. This work tries to inventorize the bacterial communities associated with this important vector species. Acquisition of gut microbiota may be the parental origin, while some are obtained through feeding during larval stages. Culicoides oxystoma possesses semi‐aquatic life cycle strategies for egg‐laying and larval survival. The bacteria associated with C. oxystoma were compared throughout (i) life stages: egg, larval instars, pupa, adult: male and female obtained from laboratory colony; (ii) field‐collected adult: male and age‐graded females; and (iii) natural breeding substrate and artificial rearing substrate. The culture‐dependent bacteria were identified by Sanger sequencing of 16S rRNA, and haemolytic bacteria were screened on blood agar. Results show that Firmicutes and Proteobacteria are the predominant Phyla, of which Bacillus spp. was the most abundant across the life stages. Across the life history, Bacillus cereus, Bacillus pumilus, Bacillus tropicus, Lysinibacillus sp. and Paenibacillus sp. were retrieved routinely. Bacillus cereus and Alcaligenes faecalis were detected in the lab‐reared specimens and shared between the natural breeding site and rearing medium. From the adults trapped across two locations, B. cereus, Bacillus flexus, A. faecalis, Enterococcus faecium and Pseudomonas sp. were isolated. The bacterial species associated with this vector may influence various physiological traits, such as vectorial capacity, digestion and larval development, which need further investigation.
Assessment of the causal relationship between inflammatory bowel diseases and chronic kidney diseases: A two‐sample bidirectional mendelian randomization study among European population
Authors: Li Xingxing , Ge Qiaoyue , Yu Chuan , Zhao Wenting , Wu Chenxin , Liu Zhenmi , Meng Xiandong , Xiao Chenghan 
Published: August 2024

AbstractBackgroundKidney function can be impaired in patients with inflammatory bowel diseases (IBD), including Crohn's diseases (CD) and ulcerative colitis (UC). However, the causal relationship between IBD and chronic kidney diseases (CKD) remains unclear.MethodsWe determined the causal association between IBD and CKD by performing two‐sample bidirectional mendelian randomization (MR) analyses. Independent genetic variants were selected as instrumental variables (IVs) of the exposure from open‐access genome‐wide association studies (GWAS) among European ancestry. IVs–outcome estimates were extracted from three separate GWAS for IBD and two for CKD, respectively. Inverse‐variance‐weighted model was used as the primary MR method. The pleiotropic effect and heterogeneity were evaluated. For either direction, analyses were performed per outcome database and were subsequently meta‐analysed.ResultsGenetically predicted IBD was associated with higher risk of CKD (OR: 1.045, 95% CI: 1.016–1.073, P = 0.002) by including 42 344 IBD cases and 229 164 controls. Further analyses showed genetic liability to CD increased the risk of CKD (OR: 1.057, 95% CI: 1.027–1.087, p < 0.001) whereas UC did not (OR: 0.999, 95% CI:0.969–1.031, p = 0.970). In contrast, genetically predicted CKD was not associated with IBD (OR: 1.010, 95% CI: 0.965–1.056, p = 0.676), UC (OR: 1.011, 95% CI: 0.948–1.078, p = 0.746) and CD (OR: 1.024; 95% CI: 0.963–1.089, p = 0.447).ConclusionsWe concluded that CD, but not UC, can increase the risk of CKD causally. CD, but not UC, can increase the risk of chronic kidney disease causally. These findings enhance our understanding of the differential impact of IBD subtypes on CKD. It may be necessary to monitor kidney function regularly in patients with CD.
Factors related to resilience and attitudes towards care of the dying among critical care nurses
Authors: Kondo Akiko , Oki Tomomi , Eckhardt Ann L. 
Published: August 2024

AbstractBackgroundMany critical care nurses provide care to patients who are injured or ill and are at the end‐of‐life. Therefore, they are at high risk for developing negative emotional responses due to exposure to patient suffering and death.AimTo determine the association between attitudes towards care of the dying, resilience, and Sense of Coherence.Study DesignA cross‐sectional descriptive approach was used. Head nurses at 74 hospitals in Japan were sent a letter about the study; 29 head nurses agreed to send information to the critical care nurses in their hospital. Demographic factors, attitudes towards care of the dying, resilience, and Sense of Coherence were collected using Google Forms. Structural equation modelling was used to analyze the associations among the variables.ResultsA total of 229 nurses completed the survey. The average years of clinical experience were 10.5 ± 8.4 years. Factors directly related to positive attitudes towards care of the dying were higher resilience, more years of clinical nursing experience, and having a Master's degree. Sense of Coherence was the strongest predictor of resilience. Other predictors for higher resilience included confidence in nursing skills, social support, and religious beliefs towards death. The main predictor for higher Sense of Coherence was workplace satisfaction.ConclusionNurses with higher resilience had more positive attitudes about care of the dying. Individual factors, such as a Sense of Coherence, confidence in caring for patients, and religious beliefs were the most important factors related to resilience.Relevance to Clinical PracticeIt is necessary to support newer nurses especially those with lower educational attainment, to increase workplace satisfaction, Sense of Coherence and resilience. It is necessary to develop educational programs focused on care of dying patients and to evaluate their effect so that critical care nurses have a positive response to caring for dying patients.
Randomized Controlled Trial of a Novel Cementless vs. Cemented Total Knee Arthroplasty: Early Clinical and Radiographic Outcomes
Authors: Zhao Enze , Zhu Xiaoyan , Tang Haiwei , Luo Zhenyu , Zeng Weinan , Zhou Zongke 
Published: August 2024

ObjectivePrevious cementless total knee arthroplasty (TKA) designs faced challenges with insufficient initial fixation on tibial side, resulting in inferior functional outcomes and survival rates. The Zoned Trabecular Bone Cementless Knee is a novel implant designed for cementless TKA which aims to achieve excellent initial fixation, promoting effective osseointegration. The aim of this research was to compare the early clinical and radiographic results of this cementless TKA with cemented TKA.MethodsBetween September 2021 and April 2022, 64 patients (64 knees) were recruited in this prospective randomized controlled trial to receive either cementless 3D‐printed trabecular metal TKA or a cemented posterior stabilized TKA. Preoperative and postoperative clinical evaluations, including the range of motion (ROM), Knee Society Score (KSS), and the Reduced Western Ontario and MacMaster Universities Score (WOMAC), were conducted and analyzed for comparison. Radiographs and computed tomography scans were utilized to assess the initial fixation. The complications between the two groups were also recorded and compared. Continuous data were analyzed for significance using independent‐samples t‐test or the Mann–Whitney U test and categorical data were analyzed using chi‐squared or Fisher's exact test.ResultsBoth groups demonstrated significant enhancement at 12 months follow‐up in the ROM compared with baseline (ROM: 94.7 ± 23.4 vs. 113.1 ± 12.3 in cementless group and 96.5 ± 14.7 vs. 111.0 ± 12.8 in cemented group, p < 0.05). However, no statistical differences were observed between the two groups in postoperative ROM, KSS, or WOMAC score. The radiographs and computed tomography scans showed similar results, including radiolucent lines and osteolysis in either femoral or tibial. Additionally, there was no statistical difference in the overall complication rate between the two groups. Notably, one patient in the cementless TKA group required revision for periprosthetic infection as the end point.ConclusionsThis novel 3D‐printed trabecular metal cementless TKA achieved comparable clinical outcomes and initial fixation to cemented TKA in early stage. Longer‐term examination is necessary to validate these results.
A case of Conradi‐Hünermann‐Happle syndrome treated with topical simvastatin‐cholesterol ointment
Authors: Zevallos Jean , Susano Stephanie 
Published: August 2024

AbstractConradi‐Hünermann‐Happle syndrome is a rare genodermatosis affecting cholesterol metabolism caused by pathogenic variants in the emopamil binding protein (EBP) gene. It presents with skin, skeletal, and ophthalmological alterations. Cutaneous findings include hyperkeratotic lesions following Blaschko lines that subsequently improve leaving scarring alopecia and patches of atrophy. The purpose of this case report is to present a case of a patient treated with simvastatin‐cholesterol ointment.