bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current and preferred services of specialized professionals in childcare settings in Quebec, Canada: A descriptive survey of childcare administrators' perspectives
Authors: Pratte Gabrielle , Beaudoin Audrée Jeanne , Camden Chantal , Couture Mélanie 
Published: July 2024

AbstractBackgroundMany challenges exist in promoting inclusion in childcare settings. Adequate support from specialized professionals is necessary to create inclusive childcare settings. Understanding which services are being delivered by specialized professionals in childcare contexts is an important first step. The aim of this study was to (1) describe the services currently being delivered by specialized professionals in childcare settings in Quebec (Canada) and (2) seek childcare administrators' perspectives on their preferred services.MethodsAn online province‐wide descriptive survey was conducted with childcare administrators (n = 344). Questions focused on 11 service delivery dimensions (e.g. professionals involved, children served). Descriptive statistics were calculated.ResultsChildcare settings received services from a median of two specialized professionals (IQR [1–4]). Most services were delivered by early childhood special educators (61.3%), speech‐language pathologists (57.6%), psycho‐educators (43.6%) and occupational therapists (43.3%). Childcare administrators identified these four services as being particularly supportive. Professionals delivered a median of 0.4 h of service per week in each childcare setting (IQR [0.1–3.0]). A high percentage (91.2%) of administrators reported unmet needs for professional support in at least one developmental domain, with a high percentage (57.3%) of administrators identifying needs in the socio‐emotional domain. Most (63.3%) expressed a desire to prioritize services for children without an established diagnosis but identified by early childhood educators as having needs for professional support. Most administrators (71.4%) also preferred in‐context services.ConclusionsChildcare administrators perceive an important role for specialized professionals in supporting inclusion in their settings. Recommendations emerging are based on the four main professional service needs identified: (1) increasing the intensity and stability of services; (2) providing services for undiagnosed children identified by early childhood educators as having unmet needs; (3) ensuring that services encompassing all developmental domains with a focus on the socio‐emotional domain; and (4) prioritizing of in‐context services.
CD300LF+ microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway
Authors: Lu Zhichao , Liu Zongheng , Wang Chenxing , Jiang Rui , Wang Ziheng , Liao Weiquan , Wang Wei , Chen Jianfeng , Zhu Xingjia , Zhao Jingwei , Liu Qianqian , Yang Yang , Gong Peipei 
Published: July 2024

AbstractIntroductionThe diversity in microglial phenotypes and functions following traumatic brain injury (TBI) is poorly characterized. The aim of this study was to explore precise targets for improving the prognosis of TBI patients from a microglial perspective.ObjectivesTo assess whether the prognosis of TBI can be improved by modulating microglia function.ResultsIn CD300LF‐deficient mice, we observed an increase in glial cell proliferation, more extensive neuronal loss, and worsened neurological function post‐TBI. Transcriptomic comparisons between CD300LF‐positive and CD300LF‐negative microglia illuminated that the neuroprotective role of CD300LF is principally mediated by the inhibition of the STING signaling pathway. In addition, this protective effect can be augmented using the STING pathway inhibitor C‐176.ConclusionsOur research indicates that CD300LF reduces neuroinflammation and promotes neurological recovery after TBI, and that microglia are integral to the protective effects of CD300LF in this context. In summary, our findings highlight CD300LF as a critical molecular regulator modulating the adverse actions of microglia following acute brain injury and propose a novel therapeutic approach to enhance outcomes for patients with TBI.
Cytology or Multiparameter Flow Cytometry Positivity in the Cerebrospinal Fluid Before Transplantation is Predictive of Poor Outcomes After Allotransplantation in Acute Myeloid Leukemia Patients
Authors: Hu Li‐Juan , Fu Guo‐Mei , Zhang Yuan‐Yuan , Wang Ya‐Zhe , Qin Ya‐Zhen , Lai Yue‐Yun , Shi Hong‐Xia , Jiang Hao , Zhang Xiao‐Hui , Xu Lan‐Ping , Wang Yu , Jiang Qian , Huang Xiao‐Jun , Chang Ying Jun 
Published: July 2024

ABSTRACTIntroductionCentral nervous system leukemia (CNSL) remains a serious complication in patients with acute myeloid leukemia (AML) and an ambiguous prognostic factor for those receiving allo‐geneic hematopoiesis stem cell transplantation (allo‐HSCT). It is unknown whether using more sensitive tools, such as multiparameter flow cytometry (MFC), to detect blasts in the cerebrospinal fluid (CSF) would have an impact on outcome.MethodsWe retrospectively analyzed the clinical outcomes of 1472 AML patients with or without cytology or MFC positivity in the CSF before transplantation. Abnormal CSF (CSF+) was detected via conventional cytology and MFC in 44 patients at any time after diagnosis. A control group of 175 CSF‐normal (CSF−) patients was generated via propensity score matching (PSM) analyses according to sex, age at transplant, and white blood cell count at diagnosis.ResultsCompared to those in the CSF‐negative group, the conventional cytology positive and MFC+ groups had comparable 8‐year nonrelapse mortality (NRM) (4%, 4%, and 6%, p = 0.82), higher cumulative incidence of relapse (CIR) (14%, 31%, and 32%, p = 0.007), lower leukemia‐free survival (LFS) (79%, 63%, and 64%, p = 0.024), and overall survival (OS) (83%, 63%, and 68%, p = 0.021), with no significant differences between the conventional cytology positive and MFC+ groups. Furthermore, multivariate analysis confirmed that CSF involvement was an independent factor affecting OS and LFS.ConclusionOur results indicate that pretransplant CSF abnormalities are adverse factors independently affecting OS and LFS after allotransplantation in AML patients.
Alkylating agents‐induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front
Authors: Sriram Sruthi , Macedo Tiago , Mavinkurve‐Groothuis Annelies , van de Wetering Marianne , Looijenga Leendert H. J. 
Published: July 2024

AbstractRising cure rates in pediatric cancer patients warrants an increased attention toward the long‐term consequences of the diagnosis and treatment in survivors. Chemotherapeutic agents can be gonadotoxic, rendering them at risk for infertility post‐survival. While semen cryopreservation is an option that can be provided for most (post)pubertal boys before treatment, this is unfortunately not an option prepubertal in age, simply due to the lack of spermatogenesis. Over the last couple of years, studies have thus focused on better understanding the testis niche in response to various chemotherapeutic agents that are commonly administered and their direct and indirect impact on the germ cell populations. These are generally compounds that have a high risk of infertility and have been classified into risk categories in curated fertility guidelines. However, with it comes the lack of evidence and the challenge of using informative models and conditions most reflective of the physiological scenario, in short, the appropriate study designs for clinically relevant outcomes. Besides, the exact mechanism(s) of action for many of these “risk” compounds as well as other agents is unclear. Understanding their behavior and effect on the testis niche will pave the way for incorporating new strategies to ultimately combat infertility. Of the various drug classes, alkylating agents pose the highest risk of gonadotoxicity as per previously established studies as well as risk stratification guidelines. Therefore, this review will summarize the findings in the field of male fertility concerning gonadotoxicity of akylating agents as a result of chemotherapy exposure.
Climate disturbances during critical periods pose risks to European hamster conservation efforts
Authors: Łopucki Rafał , Wójciak Janusz , Klich Daniel 
Published: July 2024

AbstractAimLong‐term population studies provide invaluable insights into natural variability, particularly in ecology and conservation. We reconstruct the 31‐year dynamics of the European hamster population in a vast area within Central Europe. We identify key meteorological factors influencing population dynamics and project the potential impact of climate change on their conservation.LocationPoland.MethodsAs an indicator of hamster population changes, we utilized data on the prey of the Lesser Spotted Eagle (Clanga pomarina) collected over 31 years (1993–2023) in the geographical region where the European hamster coexists. The reliability of ornithological data was validated.ResultsMeteorological factors play a critical role in driving hamster population changes. We found a strong correlation between population growth and warm weather patterns in October and November, as well as favourable conditions in March of the following year. These weather patterns allow hamsters to store larger food supplies and enter hibernation in better physiological condition, resulting in improved habitat and nutritional conditions upon emergence from hibernation in spring.Main ConclusionsOur findings underscore the importance of considering meteorological factors in conservation risk assessments, especially when planning and evaluating hamster reintroduction programmes. The significant influence of meteorological conditions raises concerns about the future prospects of this species in the context of ongoing climate change. Disturbances during critical hamster periods, including unseasonal and prolonged temperature drops in spring following relatively warm winters, pose substantial risks to conservation efforts.
Clinical outcomes of endoscopic detachable snare ligation for colonic diverticular hemorrhage: Multicenter cohort study
Authors: Kobayashi Katsumasa , Miura Natsuki , Furumoto Yohei , Ito Kenji , Iseki Mari , Kobayashi Ryohei , Yamada Yurina , Oshina Eri , Arai Katsuhiro , Matsuoka Mana , Nozaka Takahito , Sato Ayako , Yauchi Masato , Matsumoto Taichi , Asano Toru , Namiki Shin , Azuma Seishin 
Published: July 2024

ObjectivesThe hemostatic mechanism of endoscopic detachable snare ligation (EDSL) for colonic diverticular hemorrhage (CDH) is similar to that of endoscopic band ligation, which is effective and safe. However, because reports on EDSL are scarce, we conducted a two‐center cohort study to evaluate its effectiveness.MethodsThis study analyzed 283 patients with CDH treated with EDSL at two Japanese hospitals between July 2015 and November 2021. Patient characteristics and clinical outcomes were retrospectively evaluated. A Kaplan–Meier analysis was performed to evaluate the cumulative probability of rebleeding after EDSL. A Cox proportional hazards regression analysis was performed to compare the effects of complete and incomplete ligation on rebleeding.ResultsThe initial hemostasis success and early rebleeding rates were 97.9% and 11.0%, respectively. The time to hemostasis after identification of the bleeding site and total procedure time were 9 min and 44 min, respectively. Red blood cell transfusion was required for 32.9% of patients. The median hospital length of stay after EDSL was 5 days. The complete ligation rate of the early rebleeding group was significantly lower than that of the group without early rebleeding (P < 0.01). The 1‐year cumulative rebleeding rate with EDSL was 28.2%. Complete ligation was associated with decreased cumulative rebleeding after EDSL (P < 0.01). One patient experienced colonic diverticulitis; however, colonic perforation was not observed.ConclusionComplete ligation is associated with reduced short‐term and long‐term rebleeding. EDSL could be valuable for CDH because of its low rebleeding rate and the absence of serious adverse events.
Who are Nietzsche's slaves?
Authors: Gemes Ken 
Published: July 2024

AbstractThis paper argues that Nietzsche is deliberately imprecise in his characterization of what he calls the slave revolt in morality. In particular, none of the people or groups he nominates as instigators of the slave revolt, namely, Jewish priests, the Jewish people, the prophets, Jesus, and Paul, were literally slaves. Analysis of Nietzsche's texts, including his usage of the term “slaves,” and his sources concerning those he nominates as the instigators of the slave revolt, make clear that Nietzsche knew none of these were literally slaves. He calls it a slave revolt because he means that the propagators of that revolt preached what he takes to be the slavish values, including, humility, compassion, obedience, and lack of egoism. He uses the high loaded term “slave” both to disparage those values and, most importantly, to bring home to his readers the message that they, as inheritors of Judeo‐Christian values, actual adhere to and practice the debased slavish values preached, but not necessarily practiced, by the original instigators of the slave revolt. For Nietzsche, his readers are strangers to themselves, thus he notes “slavery is everywhere visible, although it does not call itself as such.”
Rhizosphere development under alternate wetting and drying in puddled paddy rice
Authors: Islam Md. Dhin , Price Adam H. , Hallett Paul D. 
Published: July 2024

AbstractAlternate wetting and drying (AWD) irrigation can save large amounts of water in rice cultivation. By repeatedly wetting and drying the soil under AWD, accentuated pore structure of the rhizosphere compared to flooded rice may occur. This could affect root growth and resource capture, but to date the physical structure and behaviour of the rhizosphere of rice under AWD has not been explored. In a controlled glasshouse experiment, two different textured soils were used in split rhizotrunks to separate a root‐zone from bulk soil using mesh. To mimic a paddy field, the top of the rhizotrunk was filled with puddled soil and below the puddled layer there was a sieved soil layer. Root‐zone physical properties were measured using a combination of high resolution X‐ray CT imaging (pore structure), a miniaturised infiltrometer (hydrological) and a small indenter (mechanical). Soil under AWD irrigation had 46% greater macroporosity and 20% more pore connectivity compared to continuous flooding (CF). Compared to the bulk soil, root‐zone soil under AWD or CF had greater macroporosity, water sorptivity and mechanical hardness. In the root‐zone, AWD compared to CF increased the rate of water absorption by around 36%, but did not affect mechanical hardness. Our results suggest AWD interacting with rice roots could promote more effective water transmission through a more stable, larger and better‐connected pore system. The results of this study also suggest that soil physical changes by AWD could improve the utilization of resources in a rice production system.
Impact of steroid biosynthesis on the aerobic adaptation of eukaryotes
Authors: Hoshino Yosuke , Gaucher Eric A. 
Published: July 2024

AbstractSteroids are indispensable components of the eukaryotic cellular membrane and the acquisition of steroid biosynthesis was a key factor that enabled the evolution of eukaryotes. The polycyclic carbon structures of steroids can be preserved in sedimentary rocks as chemical fossils for billions of years and thus provide invaluable clues to trace eukaryotic evolution from the distant past. Steroid biosynthesis consists of (1) the production of protosteroids and (2) the subsequent modifications toward “modern‐type” steroids such as cholesterol and stigmasterol. While protosteroid biosynthesis requires only two genes for the cyclization of squalene, complete modification of protosteroids involves ~10 additional genes. Eukaryotes universally possess at least some of those additional genes and thus produce modern‐type steroids as major final products. The geological biomarker records suggest a prolonged period of solely protosteroid production in the mid‐Proterozoic before the advent of modern‐type steroids in the Neoproterozoic. It has been proposed that mid‐Proterozoic protosteroids were produced by hypothetical stem‐group eukaryotes that presumably possessed genes only for protosteroid production, even though in modern environments protosteroid production as a final product is found exclusively in bacteria. The host identity of mid‐Proterozoic steroid producers is crucial for understanding the early evolution of eukaryotes. In this perspective, we discuss how geological biomarker data and genetic data complement each other and potentially provide a more coherent scenario for the evolution of steroids and associated early eukaryotes. We further discuss the potential impacts that steroids had on the evolution of aerobic metabolism in eukaryotes, which may have been an important factor for the eventual ecological dominance of eukaryotes in many modern environments.
Protein degradation by a component of the chaperonin‐linked protease ClpP
Authors: Ishikawa Fumihiro , Homma Michio , Tanabe Genzoh , Uchihashi Takayuki 
Published: July 2024

AbstractIn cells, proteins are synthesized, function, and degraded (dead). Protein synthesis (spring) is important for the life of proteins. However, how proteins die is equally important for organisms. Proteases are secreted from cells and used as nutrients to break down external proteins. Proteases degrade unwanted and harmful cellular proteins. In eukaryotes, a large enzyme complex called the proteasome is primarily responsible for cellular protein degradation. Prokaryotes, such as bacteria, have similar protein degradation systems. In this review, we describe the structure and function of the ClpXP complex in the degradation system, which is an ATP‐dependent protease in bacterial cells, with a particular focus on ClpP.
“This is my job now”: Exploring the identity shift of trailing mothers through the lens of feminist mothering
Authors: Slobodin Ortal 
Published: July 2024

AbstractTrailing spouses who relocate to support their partners' careers abroad often experience a threat or challenge to their sense of identity. Prior studies have shown that because expatriation processes reinforce traditional gender roles, expatriate mothers are involved in intensive mothering practices and ideologies, often as a way of finding new meaning in their lives. The current study aimed to explore how motherhood and professional identity intersect in trailing wives, and specifically, whether expatriate‐related developments in professional and mother identities reciprocally influence each other. In addition, the study explored whether these identity development processes may be intertwined with current sociocultural norms of motherhood. The study included in‐depth interviews with 14 trailing mothers of children under the age of 12. Thematic analysis was used to identify patterns of meaning across the dataset. Three main themes emerged capturing participants' experiences of their identity processes: negotiating the model of intensive mothering, mutual influence of mother identity and work identity, and empowered mothering. Together, these themes demonstrate how, through the subjective construction of their work and mother identities, expatriate mothers deconstruct the oppressive mandates of motherhood, reclaiming their power and agency.
Conceptualizing multimodal feedback literacy for L2 writing teachers in the digital age
Authors: Jiang Lianjiang , Lee Icy , Yu Shulin 
Published: July 2024

AbstractGiven that feedback is increasingly digital and multimodal, there is a pressing need to prepare L2 writing teachers to give multimodal feedback. Yet the notion of multimodal feedback appears underrepresented in extant research on teacher feedback literacy and it is often equated as multimedia feedback. To make feedback relevant to multiplicity in feedback‐giving modes and technologies, as well as diversity in student backgrounds and composing practices, this paper proposes the construct of multimodal feedback literacy as an important part of teacher feedback literacy. Grounded in social semiotic of multimodality, this paper elucidates the notions of feedback design, feedback affordance, feedback orchestration, and feedback ensemble as essential dimensions of multimodal feedback literacy. We argue that the development of multimodal feedback literacy entails competences in recognizing the affordances of multiple feedback‐giving modes, designing coherent feedback ensembles through orchestrating multiple feedback‐giving modes with apt intermodal relations, and managing feedback ensemble as motivated and accumulative. A framework for L2 writing teachers to develop multimodal feedback literacy in relation to a complex and recursive process of being, doing, and becoming is also developed. Implications and challenges are then discussed.
The Global Intellectual Disability Nursing Research Collaboratory: Forming an international transformational nursing network
Authors: Fisher Kathleen M. , Desroches Melissa L. , Northway Ruth , Marsden Daniel , Horan Paul , Rees Stacey 
Published: July 2024

AbstractAimThis paper explains how we created the Global Intellectual Disability Nurse Research Collaboratory (GIDNRC), a transformative network. The GIDNRC aims to make improvements in the understanding, research, policy, clinical care, and support provided to people with an intellectual disability.BackgroundIn 2022, the World Health Organization (WHO) called upon healthcare leaders internationally to take actions to promote more equal healthcare for disabled persons. This paper promotes the GIDNRC as a way for professionals to work together to make more equal healthcare throughout the world for people with intellectual disabilities.Sources of evidenceWe created this paper by reviewing peer‐reviewed literature and research, international policies, and nursing networking initiatives.DiscussionThis paper explores current policy, research, and practice issues that formed the basis of beginning the GIDNRC, including how the COVID‐19 pandemic changed care.ConclusionNurses are over 50% of the world's health workforce. Therefore, they have the potential to make a large impact in making care for people with intellectual disability much more equal than currently exists throughout the world. However, barriers exist. Forming the GIDNRC, as well as using the World Wide Web, offers an opportunity to address barriers to this goal.Implications for nursing practiceNurses can address the needs of people with intellectual disability in their daily nursing practice. The GIDNRC aims to strengthen these clinical skills, understand how care may vary throughout the world, and share knowledge, good practices, and new ways to approach care for people with an intellectual disability worldwide.Implications for nursing policyInternational nursing policy should actively focus on the needs of people with intellectual disabilities and the role nurses play in addressing these health needs. The GIDNRC may provide an important way to achieve developments in this policy.