bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing Bone Density Pattern and Porosity in the Human Ossicular Chain using Synchrotron Microtomography
Authors: Ivanovic Aleksandra , Schalbetter Fabian , Schmeltz Margaux , Wimmer Wilhelm , Caversaccio Marco , Stampanoni Marco , Bonnin Anne , Anschuetz Lukas 
Published: July 2024

Abstract

The auditory ossicles amplify and transmit sound from the environment to the inner ear. The distribution of bone mineral density is crucial for the proper functioning of sound transmission as the ossicles are suspended in an air-filled chamber. However, little is known about the distribution of bone mineral density along the human ossicular chain and within individual ossicles. To investigate this, we analyzed fresh-frozen human specimens using synchrotron-based phase-contrast microtomography. In addition, we analyzed the volume and porosity of the ossicles. The porosity for the auditory ossicles lies, on average, between 1.92% and 9.85%. The average volume for the mallei is 13.85 ± 2.15 mm3, for the incudes 17.62 ± 4.05 mm3 and 1.24 ± 0.29 mm3 for the stapedes. The bone density distribution showed a similar pattern through all samples. In particular, we found high bone mineralization spots on the anterior crus of the stapes, its footplate, and along areas that are crucial for the transmission of sound. We could also see a correlation between low bone mineral density and holey areas where the bone is only very thin or missing. Our study identified a similar pattern of bone density distribution within all samples: regions exposed to lower forces generally show higher bone density. Further, we observed that the stapes shows high bone mineral density along the anterior crus and its footplate, which may indicate its importance in transmitting sound waves to the inner ear.
“Nosotros no somos parte de la sociedad”. Creencias sociales y orientaciones emocionales colectivas como barreras psicosociales para la reintegración de personas desmovilizadas en Bucaramanga, Colombia
Authors: Gómez Meneses Diana Carolina , Villa Gómez Juan David , Navas Álvarez Celeste , Núñez Palencia Jhonnier Andrés , González Rincón Lizeth Daniela 
Published: July 2024

En Colombia se ha librado un conflicto armado interno durante más de sesenta años con violaciones flagrantes a los Derechos Humanos. Simultáneamente, se han desarrollado procesos de negociación para finalizarlo, que han conducido a ejercicios de justicia transicional y reintegración de los excombatientes que, a su vez, posibiliten la protección de los derechos de las víctimas. Estos procesos no han estado libres de tensiones importantes con sectores sociales que se han opuesto a los intentos de diálogo que, en el marco de la negociación entre el Estado Colombiano y las Fuerzas Armadas Revolucionarias de Colombia, Ejército del Pueblo (FARC-EP), han dado lugar a la configuración de barreras psicosociales para la construcción de la paz y la reconciliación. Este estudio tiene como objetivo comprender las percepciones sobre las barreras psicosociales, creencias sociales y orientaciones emocionales colectivas, para la reintegración y la reconciliación de personas desmovilizadas en Colombia. Se implementó una investigación cualitativa con diseño hermenéutico y una entrevista a profundidad. Participaron 5 personas desmovilizadas (2 mujeres y 3 hombres) de grupos paramilitares y guerrilleros. Se encontró que las personas desmovilizadas perciben barreras psicosociales (BPS) de manera estructural en espacios sociales, institucionales, laborales, a nivel financiero y en los procesos de reparación. Las creencias y las emociones como barreras para la paz se presentan como obstáculos para la generación de nuevas perspectivas que permitan la resolución del conflicto y, por ende, la instauración de una cultura de paz y reconciliación.
Performance evaluation of a hybrid treatment system for the treatment of grey water
Authors: V. Preethi , V. S. Priya , M. Sathish Kumar , S. Samsundar , R. Parthasarathy , R. P. Reswanth 
Published: July 2024

ABSTRACT

The performance of a combined up-flow submerged aerated biological filter (SABF) and photocatalytic process (PC) for the treatment of grey water was studied. The removal of COD, hardness, alkalinity, and turbidity was considered. The removal efficiency of SABF using organic and inorganic packing materials was evaluated. The combined SABF and PC removed 100% of COD, up to an organic loading rate (OLR) of 0.21 ± 0.05 kg/m3/day at 12 h HRT, irrespective of the packing media. The fibrous outer shell of coconut fibres favoured turbidity removal, but both the organic and inorganic packing materials showed equal performance in the removal of physicochemical parameters of the grey water.
Afetos e paixões: à procura de uma cura
Authors: Borges Maria 
Published: July 2024

Nesse artigo, mostrarei como Kant antecipa a utilização de estratégias fisiológicas para o controle de afetos que escapam ao nosso controle racional. Inicio apresentando a concepção kantiana de afetos e paixões como doenças da mente. Abordarei, então, a concepção de amor em Kant, comparando-a com a abordagem contemporânea deste sentimento por Brian Arp e Julian Savulescu em Love is the Drug: the chemical future of our relationships. Kant concebia os afetos como estados de carência ou excesso de excitação, seguindo a divisão do médico John Brown das doenças em astênicas e estênicas. Quando esses afetos são excessivos, ou excluem o domínio da razão, eles podem dar origem a doenças da mente, as quais, em casos extremos, devem ser curadas mediante uma estratégia medicamentosa. Por fim, mostro que a estratégia de utilização de medicamentos para regular afetos intensos não era estranha à teoria kantiana.
Palavras-chave: afeto, paixão, amor, Kant, cura
Resolutive Treatment of Actinic Keratosis through Peptides Extracted
from Zebrafish Conveyed Across Laser-assisted Transcutaneous
Delivery (Cryopass Therapy)
Authors: Biava Pier Mario , Ciaurelli Stefano , Nicolini Andrea , Ferrari Paola , Pensotti Andrea , Zafiropulo Sofia , Bonizzoni Enrico , Bonizzoni Emilio 
Published: July 2024

Introduction:
Actinic keratoses (AKs) are humans' most common keratinocyte-derived precancerous lesions. They can be observed predominantly in fair-skinned
individuals on sun-exposed surfaces. Another name for AKs is solar keratosis. The primary risk factor for AKs is cumulative UV exposure from sunlight and/or tanning salons. AKs may present on a patient as a few detectable lesions. Clinically, they present
as scaly erythema lesions with various pigmentations. Surgery treatment is the only approach that can definitively resolve the illness.

Method:
The research aims to demonstrate the effectiveness of treating relapsing AKs
through the use of factors present during organogenesis extracted from zebrafish caviar
conveyed through a cryopass therapy device (cryolaser phoresis). These factors are peptides present during specific phases of organogenesis and have shown the capacity to reverse cancer and neurodegeneration processes through gene, transcriptional, translational,
and post-translational regulation.

Result:
We found that 90% of patients responded. The percentage of responding patients was 100% among females and 80% among men.

Conclusion:
Our results confirm previous findings about the effectiveness of stem cell
differentiation stage factors (SCDFs) in cancer and open new ways to integrate treatment.
Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS
Authors: Meng Zhaoyang , Chen Junjun , Xu Lingyan , Xiao Xiao , Zong Ling , Han Yonglong , Jiang Bo 
Published: July 2024

Background:
Paclitaxel (PTX) is a key drug used for chemotherapy for various cancers. The hy-droxylation metabolites of paclitaxel are different between humans and rats. Currently, there is little infor-mation available on the metabolic profiles of CYP450 enzymes in rats.

Objective:
This study evaluated the dynamic metabolic profiles of PTX and its metabolites in rats and in vitro.

Methods:
Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrome-try (UHPLC-Q-TOF-MS) and LC-MS/MS were applied to qualitative and quantitative analysis of PTX and its metabolites in rats’ liver microsomes and recombinant enzyme CYP3A1/3A2. Ten specific inhibitors [NF (CYP1A1), FFL (CYP1A2), MOP (CYP2A6), OND (CYP2B6), QCT (CYP2C8), SFP (CYP2C9), NKT (CYP2C19), QND (CYP2D6), MPZ (CYP2E1) and KTZ (CYP3A4)] were used to identify the metabolic pathway in vitro.

Results:
Four main hydroxylated metabolites of PTX were identified. Among them, 3'-p-OH PTX and 2-OH PTX were monohydroxylated metabolites identified in rats and liver microsome samples, and 6α-2-di-OH PTX and 6α-5"-di-OH PTX were dihydroxylated metabolites identified in rats. CYP3A recombinant enzyme studies showed that the CYP3A1/3A2 in rat liver microsomes was mainly responsible for metabolizing PTX into 3'-p-OH-PTX and 2-OH-PTX. However, 6α-OH PTX was not detected in rat plasma and liver microsome samples.

Conclusion:
The results indicated that the CYP3A1/3A2 enzyme, metabolizing PTX into 3'-p-OH-PTX and 2-OH-PTX, is responsible for the metabolic of PTX in rats. The CYP2C8 metabolite 6α-OH PTX in humans was not detected in rat plasma in this study, which might account for the interspecies metabolic differences between rats and humans. This study will provide evidence for drug-drug interaction research in rats.
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies
Authors: Rathee Sunny , Sen Debasis , Pandey Vishal , Jain Sanjay K. 
Published: July 2024

:
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by
the presence of amyloid-β (Aβ) plaques and tau-containing neurofibrillary tangles, leading to cognitive
and physical decline. Representing the majority of dementia cases, AD poses a significant
burden on healthcare systems globally, with onset typically occurring after the age of 65. While
most cases are sporadic, about 10% exhibit autosomal forms associated with specific gene mutations.
Neurofibrillary tangles and Aβ plaques formed by misfolded tau proteins and Aβ peptides
contribute to neuronal damage and cognitive impairment. Currently, approved drugs, such as
acetylcholinesterase inhibitors and N-methyl D-aspartate receptor agonists, offer only partial
symptomatic relief without altering disease progression. A promising development is using lecanemab,
a humanized IgG1 monoclonal antibody, as an immune therapeutic approach. Lecanemab
demonstrates selectivity for polymorphic Aβ variants and binds to large soluble Aβ aggregates,
providing a potential avenue for targeted treatment. This shift in understanding the role
of the adaptive immune response in AD pathogenesis opens new possibilities for therapeutic interventions
aiming to address the disease's intricate mechanisms. This review aims to summarize recent
advancements in understanding Alzheimer's disease pathophysiology and innovative therapeutic
approaches, providing valuable insights for both researchers and clinicians.
The Importance of Long-term Partner Observation in Cognitive Evaluation: A Very Early Creutzfeldt-Jakob Disease in a Patient with Mild Cognitive Impairment
Authors: Yuksel Hatice , Bademci Eren Elif , Maldar Baris , Titiz Ayse Pinar 
Published: July 2024

Background:
Creutzfeldt-Jakob disease (CJD) is a fatal degenerative brain disease characterized
by rapidly progressive dementia. Sporadic CJD (sCJD) is the best-known and most common
subtype. Because the disease is uncommon and has highly diverse presenting symptoms, early
diagnosis is challenging. We herein report a case of probable sCJD diagnosed at a very early
stage.

Case Presentation:
A 61-year-old female patient had mild attention and memory problems for a
few months that were noticed by her husband but did not bother her and did not affect her daily
life activities. The first brain magnetic resonance imaging (MRI) at another hospital was normal,
lacking diffusion-weighted imaging (DWI). Although the newly taken brain MRI without DWI
was normal, the patient's husband brought his patient to our outpatient clinic because he continued
to think that there was a difference in his wife's attention and memory. A neurological examination
of the patient revealed almost normal findings. The neuropsychiatric evaluation of the patient
was consistent with mild cognitive impairment. The patient's electroencephalography taken upon
admission had no characteristic findings for CJD but showed generalized epileptiform activity.
Therefore, the patient was hospitalized, and a second brain MRI, including DWI sequences, was
performed. DWI displayed bilateral asymmetrical typical patterns of restricted diffusion. Cerebrospinal
fluid 14-3-3 was positive, and total-tau was highly elevated. She had a diagnosis of probable
sCJD at an early stage. Later, the patient developed progressive dementia, ataxia, seizures,
and extrapyramidal symptoms, followed by mutism, and died.

Conclusion:
Although there is no cure for CJD today, early diagnosis is essential, mainly because
of its potential infectivity and for future planning. Diagnosing sCJD in its early stages is difficult.
However, taking into account the observations of not only the patient's history but also their longterm
partners in cognitive evaluations will be helpful in making an early and accurate diagnosis.
Chemically Synthesized 1,2,3,4,6-Pentakis-O-Galloyl-β-D-Glucopyranoside Blocks SARS-CoV-2 Spike Interaction with Host ACE-2 Receptor
Authors: Ezell Jazmine , Al-Horani Rami A. 
Published: July 2024

Background:
In the search for anti-COVID-19 therapy, 1,2,3,4,6-pentakis-O-galloyl-β-
D-glucopyranoside, a natural polyphenolic compound isolated from many traditional medicinal
herbs, has been reported as an RBD-ACE2 binding inhibitor and as a broad-spectrum anticoronaviral
inhibitor targeting the main protease and RNA-dependent RNA polymerase of SARSCoV-
2. To facilitate the structure-activity relationship studies of 1,2,3,4,6-pentakis-O-galloyl-β-Dglucopyranoside,
we describe its chemical synthesis and characterization, as well as its activity
towards the SARS-CoV-2 spike interaction with host ACE2 receptor.

Methods:
1,2,3,4,6-Pentakis-O-galloyl-β-D-glucopyranoside was synthesized in two quantitative
steps from 3,4,5-tribenzyloxybenzoic acid and β-D-glucopyranoside: DCC-mediated esterification
and palladium-catalyzed per-debenzylation. The synthesized molecule was evaluated using a
SARS-CoV-2 spike trimer (S1 + S2) ACE2 inhibitor screening colorimetric assay kit, SARS-CoV-
2 spike S1 RBD ACE2 inhibitor screening assay kit, and a cellular neutralization assay using the
Spike (SARS-CoV-2) Pseudotyped Lentivirus, ACE2-HEK293 recombinant cell line.

Results:
The chemically synthesized product blocked the binding of the spike trimer of SARSCoV-
2 to the human ACE2 receptor with IC50=22±2 μM. It also blocked ACE2: spike RBD binding
with IC50=27±3 μM. Importantly, it inhibited the infectivity of SARS2-CoV2-Spike pseudotyped
lentivirus on the ACE2 HEK293 cell line with IC50=20±2 μM.

Conclusion:
Overall, the chemically synthesized 1,2,3,4,6-pentakis-O-galloyl-β-D-glucopyranoside
represents a lead molecule to develop anti-SARS-CoV-2 therapies that block the initial stage of the
viral infection by blocking the virus entry to the host cell.
The Role of Serine Protease 8 in Mediating Gefitinib Resistance in Non-small Cell Lung Cancer
Authors: Gao Hai-Jing , Geng Xue-Li , Wang Ling-Ling , Zhao Chun-Nan , Liang Zong-Ying , Xing En-Hong 
Published: July 2024

Objective:
This investigation aims to explore the expression levels of serine protease 8 (PRSS8) in
gefitinib-resistant Non-Small Cell Lung Cancer (NSCLC) cell lines (PC9/GR) and elucidate its mechanism of
action.

Methods:
We measured PRSS8 expression in gefitinib-resistant (PC9/GR) and sensitive (PC9) NSCLC cell lines
using Western blot analysis. PRSS8-specific small interfering RNA (PRSS8-siRNA), a recombinant plasmid, and
a corresponding blank control were transfected into PC9/GR cells. Subsequently, Western blot analyses were
conducted to assess the expression levels of PRSS8, phosphorylated AKT (p-AKT), AKT, phosphorylated mTOR
(p-mTOR), mTOR, and various apoptosis-related proteins within each group. Additionally, a cell proliferation
assay utilizing Cell Counting Kit-8 (CCK8) was performed on each group treated with gefitinib.

Results:
PRSS8 expression was markedly higher in PC9/GR cells compared to PC9 cells (p < 0.05). The group
treated with PRSS8-siRNA exhibited significantly reduced protein expression levels of PRSS8, p-AKT, p-mTOR,
β-catenin, and BCL-2 compared to the control siRNA (Con-siRNA) group, whereas expressions of Caspase9 and
Bax were significantly increased. In the untransfected PC9/GR cells, protein expressions of PRSS8, p-AKT, pmTOR,
and BCL-2 were significantly elevated when compared with the plasmid-transfected group, which also
showed a significant reduction in Bax expression. The proliferative activity of the PRSS8-siRNA group postgefitinib
treatment was significantly diminished at 24, 48, and 72 hours in comparison to the Con-siRNA group.

Conclusion:
The findings indicate that PRSS8 contributes to the acquisition of resistance to gefitinib in NSCLC,
potentially through regulation of the AKT/mTOR signaling pathway.
A Healthcare System Employing Lightweight CNN for Disease Prediction with Artificial Intelligence
Authors: Singh Mukund Pratap , Singh Jagendra , Ravi Vinayakumar , Gupta Amar deep , Alahmadi Tahani Jaser , Shivahare Basu Dev , Diwakar Manoj , Tayal Mahima , Singh Prabhishek 
Published: July 2024

Introduction/Background
This research introduces the EO-optimized Lightweight Automatic Modulation Classification Network (EO-LWAMCNet) model, employing AI and sensor data for forecasting chronic illnesses within the Internet of Things framework. A transformative tool in remote healthcare monitoring, it exemplifies AI's potential to revolutionize patient experiences and outcomes.
This study unveils a novel Healthcare System integrating a Lightweight Convolutional Neural Network (CNN) for swift disease prediction through Artificial Intelligence. Leveraging the efficiency of lightweight CNN, the model holds promise for revolutionizing early diagnosis and enhancing overall patient care. By merging advanced AI techniques, this healthcare model holds the potential for revolutionizing early diagnosis and improving overall patient care.

Materials and Methods
The Lightweight Convolutional Neural Network (CNN) is implemented to analyze sensor data in real-time within an Internet of Things (IoT) framework. The methodology also involves the integration of the EO-LWAMCNet model into a cloud-based IoT ecosystem, demonstrating its potential for reshaping remote healthcare monitoring and expanding access to high-quality care beyond conventional medical settings.

Results
Utilizing the Chronic Liver Disease (CLD) and Brain Disease (BD) datasets, the algorithm achieved remarkable accuracy rates of 94.8% and 95%, respectively, showcasing the robustness of the model as a reliable clinical tool.

Discussion
These outcomes affirm the model's reliability as a robust clinical tool, particularly crucial for diseases benefiting from early detection. The potential transformative impact on healthcare is emphasized through the model's integration into a cloud-based IoT ecosystem, suggesting a paradigm shift in remote healthcare monitoring beyond traditional medical confines.

Conclusion
Our proposed model presents a cutting-edge solution with remarkable accuracy in forecasting chronic illnesses. The potential revolutionization of remote healthcare through the model's integration into a cloud-based IoT ecosystem underscores its innovative impact on enhancing patient experiences and healthcare outcomes.
Intelligent Routing Approaches Based on Ant Colony Optimization for
Dynamic Internet of Things Network
Authors: Sharma Anukriti , Sharma Sharad , Gupta Dushyant , Kashyap Neeru , Kumar Rajeev , Kumar Sunil 
Published: July 2024

Introduction:
This paper introduces two meta-heuristic approaches utilizing Swarm
Intelligence and ant colony optimization techniques. The strategy comprises applying smart routing technology to optimize a dynamic IoT network computed path.

Method:
The issue of route selection to achieve the target and critical factors such as network energy, left energy in each gadget, run out IoT nodes count has been explored. After rigorous iterations extending up to 1000, the simulation has yielded results for two distinctive routing approaches. The ABED (ACO- Breadth first search- Euclidean- Dynamic) and the ADED (ACODijkstra algorithm -Euclidean- Dynamic) have simulated and compared their network efficiencies
using MATLAB.

Results:
At node 200, ABED exhibits a performance advantage over ADED of 1.6%. This efficiency differential between ABED and ADED expands to 2.9% at 300 nodes and further to 2.6%
at 400 nodes. Furthermore, ABED showcases superior network stability in routing techniques
compared to ADED. Specifically, ABED's routing technique achieves a more consistent network
compared to ADED.

Conclusion:
In networks comprising 500 nodes, ABED surpasses ADED by 13.33% in the context of HND (Half Node Dead) and by 6.7% in the case of LND (Last Node Dead).
گرفتی ژماره‌ (Dyscalculia) لای قوتابیانی بازنه‌ی یه‌كه‌م له‌ قوتابخانه‌ بنه‌ڕه‌تیه‌كانی شاری چه‌مچه‌ماڵ
Authors: Mohammed Mrywan Abdulmajeed , Ali Suzan Mahmuod , Hoshiar Payam , Sardar Gashbin 
Published: July 2024

ئامانجی ئەم توێژینەوەیە بۆ لێکۆڵینەوەیه‌ لە دیسكالكولیا له‌ نێوان خوێندکارانی بازنه‌ی یەکەم لە قوتابخانە سەرەتاییەکاندا لە ڕووی ڕەگەز، ته‌مه‌ن، و پۆل و قوتابخانەوه‌. كێشه‌ی ژماره‌ یان دیسکالکولیا تێکچوونێکی تایبەتی فێربوونه‌و بەربەستێکە لە بیرکاریدا،ئه‌م توێژینه‌وه‌یه‌ قوتابیانی بازنه‌ی یه‌كه‌می‌ ‌ پۆلەکانی یەکەم و دووەم و سێیەم لەخۆ دەگرێت له‌ پارێزگای سلێمانی. دیارترین نیشانه‌كانی كێشه‌ی ژماره‌: به‌ زەحمەتی تێگەیشتن لە وشەکانی "لێكدان"، "کۆکردنەوە"، کێشە لە ژماردن، حەز نەکردن بە ژمێریاری و خەمڵاندن و هەستکردنێکی زۆر خراپ لە چەمک و یاسا و شیكاری‌ بیرکاری له‌ خۆده‌گرێت، هه‌روه‌ها گرنگترین ئه‌و تیۆریانه‌ی له‌م توێژینه‌وه‌یه‌دا خراونه‌ته‌ڕوو ئه‌مانه‌ن: تیۆری بوونیادنانی مەعریفی بیاجه‌، تیۆری گەشەپێدانی مەعریفی، مۆدێلی سێ کۆد و مۆدێلی سیستەمی پرۆسێسی ژمارە كه‌ هه‌موو ئه‌م تیۆریانه‌ یارمه‌تی باش تێگه‌یشتنی ئێمه‌ ده‌ده‌ن تا زیاتر له‌ كێشه‌ی ژماره‌ تێبگه‌ین. جگه‌ له‌مه‌ش توێژینه‌وه‌كانی پێشوو ئه‌وه‌ ده‌خه‌نه‌ڕوو كه‌ هه‌ندێك هۆكاری ژینگه‌یی و كۆمه‌ڵایه‌تی و ده‌ررونی و په‌روه‌رده‌یی و بۆماوه‌یی ده‌بنه‌ هۆی ئه‌م دیارده‌یه‌. توێژه‌‌ران ‌ سوودیان له‌ ڕاپرسی پێشوه‌خته‌ بینیوه‌و وه‌ریانگێراوه بۆ زمانی كوردی كه‌ له (‌22) بڕگه‌ پێك هاتووه‌، هه‌رورها دوای وه‌رگرتنی بۆچوونی شاره‌زایان، (102) قوتابی له‌ دیدی مامۆستایه‌نه‌وه‌ وه‌رگیراوه‌. به‌ سوود بینین له‌ پرۆسه‌ی ئاماری (SPSS- 26) شیكاری داتاكان كراون. ده‌رئه‌نجام: ئه‌م توێژینه‌وه‌یه‌ ڕاستگۆیی و جێگیری زۆرباشی هه‌یه‌، وه‌ ئه‌وه‌ خراوه‌ته‌ڕوو كه‌ ڕێژه‌ی كێشه‌ی ژماره‌ له‌ نێو كچاندا زیاتره‌ وه‌ك له‌ كوڕان و له‌ قوتابخانه‌ حكومیه‌كاندا به‌ تایبه‌ت له‌ نێو قوتابیانی پۆلی دووه‌م زیاتر بڵاوه وه‌ك له‌ قوتابخانه‌ ئه‌هلیه‌كان‌. بۆیه‌ له‌ ئه‌نجامی هه‌ندێك كه‌م و كورتی ئه‌م توێژینه‌وه‌یه‌، توێژه‌ران هه‌ندێك پێشنیاریان بۆ توێژینه‌وه‌كان داهاتوو خستۆته‌ڕوو له‌ گرنگترینیان: ته‌نها پشت به‌ دیدی مامۆستا نه‌به‌سترێت، به‌ڵكوئه‌نجامدانی تێست و پێوانه‌كردنی زیاتر ڕووبه‌ڕوو له‌گه‌ڵ له‌ قوتابیاندا گرنگه‌ بۆ زانینی گرفتی ژماره‌ لای قوتابیان به‌ شێوه‌یه‌كی وردتر و به‌ده‌ستهێنانی ئه‌نجامی باشتر.