bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrocardiographic Predictors of Disease Severity, Mortality, and Advanced Ventilatory Support Among Hospitalized COVID-19 Patients: A 2-Year Single- Center Retrospective, Cohort Study From January 2020 to December 2021
Authors: Vista Giovanni A , Vestal Marivic V , Perez Ma. Luisa 
Published: July 2024

INTRODUCTION: For detecting myocardial injury in severe and critical COVID-19, the electrocardiogram (ECG) is neither sensitive nor specific, but in a resource-poor environment, it remains relevant. Changes in the ECG can be a potential marker of severe and critical COVID-19 to be used for predicting not only disease severity but also the prognosis for recovery. METHODS: The admitting and interval ECGs of 1333 COVID-19 patients were reviewed in a 2-year, single-center, retrospective cohort study. Each was evaluated for 29 predefined ECG patterns under the categories of rhythm; rate; McGinn-White and right ventricular, axis, and QRS abnormalities; ischemia/infarct patterns; and atrioventricular blocks before univariate and multivariate regression analyses for correlation with disease severity, need for advanced ventilatory support, and in-hospital mortality. RESULTS: Of the 29 ECG patterns, 18 showed a significant association with the dependent variables on univariate analysis. Multivariate analysis revealed that atrial fibrillation, heart rate greater than 100 beats per minute, low QRS voltage, QTc of 500 milliseconds or greater, diffuse nonspecific T-wave changes, and “any acute anterior myocardial infarction” ECG patterns correlate with disease severity, need for advanced ventilatory support, and in-hospital mortality. S1Q3 and S1Q3T3 increased the odds of critical disease and need for high oxygen requirement by 2.5- to 3-fold. Fractionated QRS increased the odds of advanced ventilatory support. CONCLUSION: The ECG can be useful for predicting the severity and outcome of more than moderate COVID-19. Their use can facilitate rapid triage, predict disease trajectory, and prompt a decision to intensify therapy early in the disease to make a positive impact on clinical outcomes. KEYWORDS: advanced ventilatory support, COVID-19 electrocardiographic predictors, disease severity, in-hospital mortality
“To Touch or To Watch”: A Case of Venous Thromboembolism in a Triathlete Complicated by a Mobile Thrombus in the Left Subclavian Vein
Authors: Macabeo Renelene , Canlas Myra A , Fajardo Maria Janelle , Lontok Flordeliz 
Published: July 2024

Venous thromboembolism (VTE) encompasses deep venous thrombosis (DVT) and pulmonary embolism (PE). The reported incidence rates for PE (with or without DVT) range from 29 to 78 per 100,000 person-years whereas for DVT alone (without PE), range from 45 to 117 per 100,000 person-years. It is predominantly a disease of older age, and is rare prior to late adolescence. The true incidence of VTE among athletes is unknown but several cases have been reported.

We present the case of a 35-year-old Irish male with no known comorbidities, who presented with seizures on the tenth hour of a triathlon race and was subsequently diagnosed to have bilateral segmental pulmonary embolism, upper and lower extremity DVT, complicated by a mobile thrombus in the left subclavian vein. Anticoagulation was the mainstay of management of this patient and he was eventually discharged improved. A review of literature on VTE, DVT, particularly upper extremity deep venous thrombosis (UEDVT) and the patient’s hospital course are reported in this paper.
Wellens Syndrome, an Impending Doom: A Case Report
Authors: Benitez Victor Jonathan S 
Published: July 2024

BACKGROUND: Wellens syndrome, also known as “widow maker,” was first described by de Zwaan et al as a pattern of electrocardiographic changes for patients with significant left anterior descending coronary artery infarction. Early recognition could prevent an extensive infarction of the anterior wall, which could possibly lead to the demise of the patient. We present the case of a 60-year-old man who presented with sudden onset of chest pain with diaphoresis and cold clammy extremities. He was initially managed as a case of unstable angina. Further workup, which included serial electrocardiograms, led to the diagnosis of Wellens syndrome. The patient also underwent coronary angiography and angioplasty with good outcome. The patient’s course and a review of literature on Wellens syndrome are reported in this article.
The State of Cardiovascular Resources and Expertise in Echocardiography Nationwide: The Philippine Survey on Echocardiography (The PHIL-SCREEN Study)
Authors: Magno Jose Donato A , Ubaldo Rylan Jasper C , Nunez Jonnie B , Cornel Mylene U , Cuyco Ronald E , Tucay Edwin S , Santos Romeo J 
Published: July 2024

INTRODUCTION: Maldistribution of echocardiographic expertise is a relevant issue in an archipelago such as the Philippines. We specifically looked at (1) the nationwide census of physician echocardiographers, cardiac sonographers, and cardiac laboratory managers; (2) their geographic distribution; and (3) background training and laboratory classification.

METHODS: Data from paper and online surveys conducted in 2015 and 2021 were consolidated alongside the existing society database. Surveys (Google Forms; Google, Mountain View, California) were disseminated through a variety of online, social media, and communication avenues and focused on three categories of respondents: (1) physician echocardiographers, (2) cardiac sonographers, and (3) laboratory managers. The main variables of interest included estimated census per category and geographical distribution. Secondary variables included training background and laboratory classification.

RESULTS: In 2021, there were 651 physician echocardiographers, 2487 cardiac sonographers, and 443 cardiac laboratory managers on record, with 86 readers, 405 sonographers, and 101 managers responding to the survey. The majority of the surveyed readers (41.2%), sonographers (48.3%), and laboratory managers (28.2%) were situated in the National Capital Region. Close to half of the readers were level III echocardiographers. The majority of the sonographers (46.7%) were nurses, followed by medical technologists (21.8%) and radiologic technologists (18.9%). Most laboratory managers were in nontraining hospitals (38.2%) or stand-alone facilities (20.9%). The minority were in hospitals with cardiology (18.2%) or internal medicine (22.7%) training programs.

CONCLUSION: Geographical maldistribution of echocardiographic resources is still evident, with the majority of human resources being concentrated in the metropolis. The majority of the sonographers have nursing as their training background, and many laboratory managers are situated in facilities with no established training programs.

KEYWORDS: echocardiography, laboratory, reader, resources, sonographer, survey
Factors Affecting Surgical Mortality for Patients With D-Transposition of the Great Arteries: Single-Institution Experience From a Developing Country
Authors: Canto Ceres P , Hernandez Ruzenette Felicitas R , Catalan Gisel T 
Published: July 2024

INTRODUCTION: Arterial switch operation (ASO) is the preferred surgical management for D-transposition of the great arteries. It was first performed in this institution in 1991, with a high mortality from the expected learning curve. Two decades later, there is a need to revisit our outcomes to further improve surgical treatment of this common cyanotic condition.

METHODS: This is a retrospective cohort study on ASO patients between January 2010 and June 2017 from a single institution. The following parameters were collected through review of patient charts and two-dimensional echocardiography videos: clinical data, laboratory and echocardiographic results, and intraoperative and postoperative outcomes. The study was approved by the institutional ethics review board of the hospital.

RESULTS: Among 117 subjects, the median age was 1 month (range, 1 day to 6 years), and 76% were males. Transposition of the great arteries with intact septum (62%) was more frequently seen. Mortality decreased from 49% to 30%. Preoperatively, balloon atrial septostomy was associated with mortality (p = 0.013). Intraoperatively, mortality increased with prolonged cardiopulmonary bypass (p = 0.007), bleeding (p = 0.015), rebypass (p = 0.001), and metabolic acidosis (p = 0.005). Postoperatively, use of inotropes (p = 0.003), prolonged intubation (p = 0.028), pulmonary edema or severe congestion (p = 0.01), bleeding (p < 0.001), increased international normalized ratio (p = 0.047), acute renal failure (p < 0.001), peritoneal dialysis (p < 0.001), metabolic acidosis (p = 0.005), and increased C-reactive protein (p = 0.028) increased mortality. On multivariate analysis, rebypass (95% confidence interval, 1.86–175.49) and renal failure (95% confidence interval, 2.98–109.50) were strong independent predictors of mortality.

CONCLUSION: Overall mortality remains high compared with other institutions. Strategies should therefore be used to avoid statistically significant endpoints in order to improve operative outcomes. Careful preoperative planning and early institution of dialysis should be performed when needed.

KEYWORDS: D-TGA, arterial switch operation, predictors of mortality, balloon atrial septostomy
Percutaneous Transcatheter Closure of a Stented Patent Ductus Arteriosus in a Patient With Critical Pulmonary Stenosis: A Case Series
Authors: Quitola Ma. Rosita S , Reganion Juan G , Villareal Jean Antonio G 
Published: July 2024

INTRODUCTION: TStenting of the ductus is an alternative to surgical shunt in patients with critical pulmonary stenosis who remain ductal dependent following valvuloplasty. Stents close spontaneously after improvement of right ventricular function; however, in rare cases, stents fail to completely endothelialize, resulting in pulmonary overcirculation.

CASE PRESENTATION: The first case was a 3-year-old who had critical pulmonary stenosis at birth, and the second case was a 3-year-old boy who at 5 months of age was managed for severe pulmonary valve stenosis. Both underwent stenting of the duct and percutaneous pulmonary balloon valvuloplasty. On follow-up, the patent ductus arteriosus (PDA) stent of both cases remained patent even after an adequate growth and improvement of the right ventricle, resulting in significant left-to-right shunting and development of increased pulmonary blood flow; hence, percutaneous transcatheter closure of the stented PDA was done.

DISCUSSION: Stenting of the ductus allows significant and balanced growth of the pulmonary artery in patients with duct-dependent congenital heart diseases leading to adequate growth of the right ventricle. Persistence of patency of stent causing significant left-to-right shunting warrants closure of the PDA stent. Closure of the stent is challenging and requires a high degree of technical skill because of the difficulty to enter the partially closed stent.

CONCLUSION: Percutaneous transcatheter closure of a stented PDA in patients with critical pulmonary stenosis can be a technically challenging procedure because of the difficulty to enter the stent due to the presence of intrastent endothelial proliferation.

KEYWORDS: congenital heart disease, critical pulmonary stenosis, patent ductus arteriosus, transcatheter device closure, stent
Risk Factors Associated with Acute Kidney Injury in Neonates and Infants Following Open Heart Surgery
Authors: Tria Kristine Gay S , Balderas Jhuliet J , Azcueta Ma. Bernadette A , Marbella Ma. Angeles G 
Published: July 2024

BACKGROUND: The complexity of surgical cardiac procedures is on the rise, resulting in prolonged cardiopulmonary bypass time and stay in the intensive care unit. One major complication of cardiac surgery is acute kidney injury. The aim of this study is to investigate the incidence and risk factors associated with acute kidney injury following open heart surgery.

METHODOLOGY: This is a retrospective cohort study that involved chart review of patients <1 year old who underwent open heart surgery from January 2012 to December 2017 in a tertiary cardiovascular referral center. Preoperative characteristics included age, gender, weight, cardiac diagnosis, baseline serum creatinine, history of mechanical ventilation and cardiac catheterization and pre operative medications given. Intra-operative characteristics included cardiopulmonary bypass and cross clamp time of cardiac surgery, and degree of hypothermia . Post operatively, urine output, systolic blood pressure, mean arterial pressure, highest serum creatinine and blood urea nitrogen were recorded.

RESULTS: Sixty one (61) patients were included in the study. Nine patients (15%) developed post-operative acute kidney injury, two of which underwent peritoneal dialysis. Lowest systolic blood pressure and lowest mean arterial pressure were noted to be significant in the development of acute kidney injury with odds ratio of 0.95 (p=0.049) and 0.93 (p=0.025), respectively. The duration of mechanical ventilation was also significantly increased in patients who developed acute kidney injury (p=0.028).

CONCLUSION: Lowest systolic blood pressure and lowest mean arterial pressure are significant risk factors for acute kidney injury in neonates and infants following open heart surgery.

KEYWORDS: acute kidney injury, acute renal failure, cardiac surgery in infants, congenital heart disease, cardiopulmonary bypass time
Efektivitas Edukasi Health Belief Model dalam Perubahan Pengetahuan dan Perilaku Pasien Tuberkulosis
Authors: Fitriyani Lia , Dwijayanti Fifi , Ruswandi Umar , Afriansyah Eddy , Purwadi Hendro 
Published: July 2024

Indonesia menempati urutan kedua kejadian tuberkulosis setelah India dengan 1,06 juta kasus dan 134.000 kematian. Sekitar 15 orang meninggal karena TBC setiap jamnya. Jumlah kasus tuberkulosis di Kota Depok pada tahun 2019 sebanyak 4.695 kasus, tahun 2020 sebanyak 3.311 kasus, tahun 2021 sebanyak 3.974 kasus dan tahun 2022 sebanyak 6.549 kasus.Tujuan dalam penelitian ini adalah diketahuinya efektifitas edukasi health belief model (HBM) dalam perubahan pengetahuan dan perilaku tuberculosis. Penelitian ini menggunakan rancangan quasi eksperimen. Rancangan pendekatan kuasi eksperimen yang digunakan adalah one group pretest–posttest design. Penelitian ini dilakukan di Kota Depok selama 2 bulan pada januari-februari 2024. Sampel dalam penelitian ini sebanyak 60 pasien. Pengumpulan data menggunakan kuesioner. Analisis data dilakukan dengan menggunakan uji wilcoxom. Hasil penelitian ini adalah penerapan Health Belief Model efektif meningkatkan pengetahuan (p value = 0,000) dan perilaku (p value = 0,000) pasien tuberkulosis di Kota Depok. Kesimpulan dari penelitian ini adalah pemberian edukasi dengan health belief model berpengaruh terhadap pengetahuan dan perilaku. Saran dalam penelitian ini adalah melakukan evaluasi secara berkala untuk mengukur efektivitas intervensi dan melakukan penyesuaian jika diperlukan.
Efficacy of Nano Urea on Nitrogen Use Efficiency of Irrigated Maize under Temperate Ecology
Authors: Gogoi Barenya , Kanth Raihana H , Bhat Tauseef Ahmad , Saxena Amal , Khan Inayat M. , Wani Fehim J. , Nazir Aijaz , Jan Bisma , Kounsar Hadiya , Jamsheed Bilkees , Dar Khursheed Ahmad , P T Jibinsha 
Published: July 2024

A field experiment was conducted during the Kharif-2022 season at the Agronomy Research Field, FOA, SKUAST-Kashmir, to investigate the efficacy of nano-urea in improving nitrogen-use efficiency in irrigated maize. Ten treatments were evaluated viz., T1: Control, T2: Recommended dose of Nitrogen (RDN) as basal (prilled urea), T3: 75% RDN + 1 spray nano-urea at 2 ml L-1 (60 DAS), T4: 75% RDN + 1 spray at 4 ml L-1 (60 DAS), T5: 50% RDN + 2 sprays at 2 ml L-1 (30 and 60 DAS), T6: 50% RDN + 2 sprays at 4 ml L-1 (30 and 60 DAS), T7: 25% RDN + 2 sprays at 6 ml L-1 (30 and 60 DAS), T8: 25% RDN + 2 sprays at 8 ml L-1 (30 and 60 DAS), T9: 25% RDN + 1 spray at 6 ml L-1 (60 DAS), T10: 25% RDN + 1 spray at 8 ml L-1 (60 DAS). The experiment was carried out following a randomized complete block design with three replications. Results revealed that treatment T6 (50% RDN as basal + 2 sprays at 30 and 60 DAS at 4 ml L-1 of nano-urea) exhibited superior performance compared to the recommended nitrogen dose (T2) and other treatments in enhancing nutri-ent-use efficiency. Notably, treatment T6 demonstrated the highest nitrogen uptake in grain (101.92 kg ha-1) as well as stover (67.41 kg ha-1), surpassing all other treatments. Additionally, agronomic efficiency was significantly higher in T8, while physiological efficiency peaked in T6. Yield attributes and overall yield showed consistent improvements in treatments receiving nano-urea. Furthermore, treatments utilizing nano-urea demonstrated higher net returns and benefit-cost ratios, with T6 particularly standing out. These findings underscore the potential of foliar application of nano-urea to halve the recommended dose of prilled urea, thereby enhancing nitrogen uptake, nutrient-use efficiency, yield, and economic returns, while promoting sustainability in agriculture.
Automated Patch Clamp Analysis of nAChα7 and NaV1.7 Channels
Authors: Obergrussberger Alison , Haarmann Claudia , Rinke Ilka , Becker Nadine , Guinot David , Brueggemann Andrea , Stoelzle‐Feix Sonja , George Michael , Fertig Niels 
Published: June 2014

AbstractAutomated patch clamp devices are now commonly used for studying ion channels. A useful modification of this approach is the replacement of the glass pipet with a thin planar glass layer with a small hole in the middle. Planar patch clamp devices, such as the three described in this unit, are overtaking glass pipets in popularity because they increase throughput, are easier to use, provide for the acquisition of high‐quality and information‐rich data, and allow for rapid perfusion and temperature control. Covered in this unit are two challenging targets in drug discovery: voltage‐gated sodium subtype 1.7 (NaV1.7) and nicotinic acetylcholine α7 receptors (nAChα7R). Provided herein are protocols for recording activation and inactivation kinetics of NaV1.7, and activation and allosteric modulation of nAChα7R. Curr. Protoc. Pharmacol. 65:11.13.1‐11.13.48. © 2014 by John Wiley & Sons, Inc.
Using PeptideAtlas, SRMAtlas, and PASSEL: Comprehensive Resources for Discovery and Targeted Proteomics
Authors: Kusebauch Ulrike , Deutsch Eric W. , Campbell David S. , Sun Zhi , Farrah Terry , Moritz Robert L. 
Published: June 2014

AbstractPeptideAtlas, SRMAtlas, and PASSEL are Web‐accessible resources to support discovery and targeted proteomics research. PeptideAtlas is a multi‐species compendium of shotgun proteomic data provided by the scientific community; SRMAtlas is a resource of high‐quality, complete proteome SRM assays generated in a consistent manner for the targeted identification and quantification of proteins; and PASSEL is a repository that compiles and represents selected reaction monitoring data, all in an easy‐to‐use interface. The databases are generated from native mass spectrometry data files that are analyzed in a standardized manner including statistical validation of the results. Each resource offers search functionalities and can be queried by user‐defined constraints; the query results are provided in tables or are graphically displayed. PeptideAtlas, SRMAtlas, and PASSEL are publicly available freely via the Web site http://www.peptideatlas.org. In this protocol, we describe the use of these resources, we highlight how to submit, search, collate and download data. Curr. Protoc. Bioinform. 46:13.25.1‐13.25.28. © 2014 by John Wiley & Sons, Inc.
Coupled fluid and solid evolution in analogue volcanic vents
Authors: Solovitz Stephen A. , Ogden Darcy E. , Kim Dave (Dae‐Wook) , Kim Sang Young 
Published: June 2014

AbstractVolcanic eruptions emit rock particulates and gases at high speed and pressure, which change the shape of the surrounding rock. Simplified analytical solutions, field studies, and numerical models suggest that this process plays an important role in the behavior and hazards associated with explosive volcanic eruptions. Here we present results from a newly developed laboratory‐scale apparatus designed to study this coupled process. The experiments used compressed air jets expanding into the laboratory through fabricated rock analogue material, which evolves through time during the experiment. The compressed air was injected at approximately 2.5 times atmospheric pressure. We fabricated rock analogues from sand and steel powder samples with a three‐dimensional printing process. We studied the fluid development using phase‐locked particle image velocimetry, while simultaneously observing the solid development via a video camera. We found that the fluid response was much more rapid than that of the solid, permitting a quasi‐steady approximation. In most cases, the solid vent flared out rapidly, increasing its diameter by 20 to 100%. After the initial expansion, the vent and flow field achieved a near‐steady condition for a long duration. The new expanded vent shapes permitted lower vent exit pressures and larger jet radii. In one experiment, after an initial vent shape development and establishment of steady flow behavior, rock failure occurred a second time, resulting in a new exit diameter and new steady state. This second failure was not precipitated by changes in the nozzle flow condition, and it radically changed the downstream flow dynamics. This experiment suggests that the brittle nature of volcanic host rock enables sudden vent expansion in the middle of an eruption without requiring a change in the conduit flow.
The seawater neodymium and lead isotope record of the final stages of Central American Seaway closure
Authors: Osborne Anne H. , Newkirk Derrick R. , Groeneveld Jeroen , Martin Ellen E. , Tiedemann Ralf , Frank Martin 
Published: June 2014

AbstractThe shoaling and final closure of the Central American Seaway (CAS) resulted in a major change of the global ocean circulation and has been suggested as an essential driver for strengthening of Atlantic Meridional Overturning Circulation (AMOC). The exact timing of CAS closure is key to interpreting its importance. Here we present a reconstruction of deep and intermediate water Nd and Pb isotope compositions obtained from fossil fish teeth and the authigenic coatings of planktonic foraminifera in the eastern equatorial Pacific (Ocean Drilling Program (ODP) Site 1241) and the Caribbean (ODP Sites 998, 999, and 1000) covering the final stages of CAS closure between 5.6 and 2.2 Ma. The data for the Pacific site indicate no significant Atlantic/Caribbean influence over this entire period. The Caribbean sites show a continuous trend to less radiogenic Nd isotope compositions during the Pliocene, consistent with an enhancement of Upper North Atlantic Deep Water (UNADW) inflow and a strengthening of the AMOC. Superimposed onto this long‐term trend, shorter‐term changes of intermediate Caribbean Nd isotope signatures approached more UNADW‐like values during intervals when published reconstructions of seawater salinity suggested complete closure of the CAS. The data imply that significant deep water exchange with the Pacific essentially stopped by 7 Ma and that shallow exchange, which still occurred at least periodically until approximately 2.5 Ma, may have been linked to the strength of the AMOC but did not have any direct effect on the intermediate and deep Caribbean Nd isotope signatures through mixing with Pacific waters.