bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Kenyan policymakers’ perspectives about the introduction of new maternal vaccines
Authors: Limaye Rupali J , Fesshaye Berhaun , Singh Prachi , Jalang’o Rose , Njogu Rosemary Njura , Miller Emily , Schue Jessica , Sauer Molly , Lee Clarice , Karron Ruth A 
Published: July 2024

Abstract
New vaccine policy adoption is a complex process, especially in low-and-middle-income countries, requiring country policymakers to navigate challenges such as competing priorities, human and financial resource constraints, and limited logistical capacity. Since the beginning of the Expanded Programme on Immunization, most new vaccine introductions under this structure have not been aimed at adult populations. The majority of adult vaccines offered under the Expanded Programme on Immunization are not typically tested among and tailored for pregnant persons, except those that are specifically recommended for pregnancy. Given that new maternal vaccines, including respiratory syncytial virus and group B streptococcus vaccines, are on the horizon, it is important to understand what barriers may arise during the policy development and vaccine introduction process. In this study, we sought to understand information needs among maternal immunization policymakers and decision-makers in Kenya for new vaccine maternal policy adoption through in-depth interviews with 20 participants in Nakuru and Mombasa, counties in Kenya. Results were mapped to an adapted version of an established framework focused on new vaccine introduction in low-and-middle-income countries. Participants reported that the policy process for new maternal vaccine introduction requires substantial evidence as well as coordination among diverse stakeholders. Importantly, our findings suggest that the process for new maternal vaccines does not end with the adoption of a new policy, as intended recipients and various actors can determine the success of a vaccine programme. Previous shortcomings, in Kenya, and globally during human papillomavirus vaccine introduction, show the need to allocate adequate resources in education of communities given the sensitive target group. With maternal vaccines targeting a sensitive group—pregnant persons—in the pipeline, it is an opportune time to understand how to ensure successful vaccine introduction with optimal acceptance and uptake, while also addressing vaccine hesitancy to increase population benefit.
Efficacy of Ustekinumab and Vedolizumab Among Postoperative Crohn’s Disease Patients as Postoperative Prophylaxis and Rescue Therapy: Real-world Data
Authors: Ertem Furkan U , Rivers Claudia Ramos , Ghaffari Amir Ali , Watson Andrew R , Tang Gong , Schwartz Marc , Johnston Elyse , Barrie Arthur , Harrison Janet , Dueker Jeffrey M , Hartman Doug , Binion David G 
Published: July 2024

Abstract

Background
Almost half of patients with Crohn’s disease (CD) require bowel surgeries in their lifetime. Due to the high risk of postoperative disease recurrence and high rate of previous antitumor necrosis factor (anti-TNF) failure, often alternative therapy options such as ustekinumab (UST) and vedolizumab (VDZ) are used. We aimed to evaluate the efficacy of UST and VDZ among postoperative CD patients as postoperative prophylaxis and rescue therapy.

Methods
Consented CD patients who underwent initial ileocecal resection and were treated with UST and VDZ were included in this study. Demographics, clinical characteristics, health care utilization, endoscopy scores, and surgery outcomes were collected. Postoperative early CD recurrence was defined as a Rutgeerts endoscopic score ≥i2 within the first 2 years. The rescue therapy group was defined as patients who received either UST or VDZ after having Rutgeerts endoscopic score ≥i2 postoperatively.

Results
During 2009 to 2019, 98 CD patients were treated with UST or VDZ postoperatively. Postoperative early recurrence rates were 5% (n = 1 out of 20) and 6% (1 out of 15) for the UST and VDZ groups, respectively. Two patients from the UST group and 1 patient from the VDZ group required bowel surgery during follow-up with median drug exposure of 51 (95% confidence interval [CI], 29-61) and 30 (95% CI, 14-63) months, respectively; 55% and 69% of patients had at least 1 point of improvement on postoperative endoscopic Rutgeerts score, respectively, for UST and VDZ. Only 3 out of 40 and 1 out of 23 patients required bowel surgery during follow-up while receiving UST and VDZ as rescue therapy.

Conclusions
Both UST and VDZ were effective as postoperative therapies either as prophylaxis or rescue therapy.
On a Goldbach-Type Problem for the Liouville Function
Authors: Mangerel Alexander P 
Published: July 2024

Abstract
Let $\lambda $ denote the Liouville function. We show that for all $N \geq 11$, the (non-trivial) convolution sum bound $$ \begin{align*} & \left|\sum_{n &lt; N} \lambda(n) \lambda(N-n)\right| &lt; N-1 \end{align*} $$ holds. We also determine all $N$ for which no cancellation in the convolution sum occurs. This answers a question posed at the 2018 AIM workshop on Sarnak’s conjecture.
Selection of Single-Analyte Delta Check Rules with Logistic Regression for Detection of Intravenous Fluid Contamination in a Clinical Chemistry Laboratory
Authors: Yang Jianbo , Wen Sijin , McCudden Christopher R , Tacker Danyel H 
Published: July 2024

Abstract

Background
The conventional single-analyte delta check, utilized for identifying intravenous fluid contamination and other preanalytical errors, is known to flag many specimens reflecting true patient status changes. This study aimed to derive delta check rules that more accurately identify contamination.

Methods
Results for calcium, creatinine, glucose, sodium, and potassium were retrieved from 326 103 basic or comprehensive metabolic panels tested between February 2021 and January 2022. In total, 7934 specimens showed substantial result changes, of which 1489 were labeled as either contaminated or non-contaminated based on chart review. These labeled specimens were used to derive logistic regression models and to select the most predictive single-analyte delta checks for 4 common contaminants. Their collective performance was evaluated using a test data set from October 2023 comprising 14 717 specimens.

Results
The most predictive single-analyte delta checks included a calcium change by ≤−24% for both saline and Plasma-Lyte A contamination, a potassium increase by ≥3.0 mmol/L for potassium contamination, and a glucose increase by ≥400 mg/dL (22.2 mmol/L) for dextrose contamination. In the training data sets, multi-analyte logistic regression models performed better than single-analyte delta checks. In the test data set, logistic regression models and single-analyte delta checks demonstrated collective alert rates of 0.58% (95% CI, 0.46%–0.71%) and 0.60% (95% CI, 0.49%–0.74%), respectively, along with collective positive predictive values of 79% (95% CI, 70%–89%) and 77% (95% CI, 68%–87%).

Conclusions
Single-analyte delta checks selected by logistic regression demonstrated a low false alert rate.
Building blocks toward sustainable biofertilizers: variation in arbuscular mycorrhizal spore germination when immobilized with diazotrophic bacteria in biodegradable hydrogel beads
Authors: Mafune Korena K , Kasson Matt T , Winkler Mari-Karoliina H 
Published: July 2024

Abstract

Aim
We investigated whether there was interspecies and intraspecies variation in spore germination of 12 strains of arbuscular mycorrhizal fungi when co-entrapped with the diazotrophic plant growth-promoting bacteria, Azospirillum brasilense Sp7 in alginate hydrogel beads.

Methods and results
Twelve Rhizophagus irregularis, Rhizophagus intraradices, and Funneliformis mosseae strains were separately combined with a live culture of Azospirillum brasilense Sp7. Each fungal–bacterial consortia was supplemented with sodium alginate to a 2% concentration (v/v) and cross-linked in calcium chloride (2% w/v) to form biodegradable hydrogel beads. One hundred beads from each combination (total of 1200) were fixed in solidified modified Strullu and Romand media. Beads were observed for successful spore germination and bacterial growth over 14 days. In all cases, successful growth of A. brasilense was observed. For arbuscular mycorrhizal fungi, interspecies variation in spore germination was observed, with R. intraradices having the highest germination rate (64.3%), followed by R. irregularis (45.5%) and F. mosseae (40.3%). However, a difference in intraspecies germination was only observed among strains of R. irregularis and F. mosseae. Despite having varying levels of germination, even the strains with the lowest potential were still able to establish with the plant host Brachypodium distachyon in a model system.

Conclusions
Arbuscular mycorrhizal spore germination varied across strains when co-entrapped with a diazotrophic plant growth-promoting bacteria. This demonstrates that hydrogel beads containing a mixed consortium hold potential as a sustainable biofertilizer and that compatibility tests remain an important building block when aiming to create a hydrogel biofertilizer that encases a diversity of bacteria and fungi. Moving forward, further studies should be conducted to test the efficacy of these hydrogel biofertilizers on different crops across varying climatic conditions in order to optimize their potential.
Zoledronic acid for hip fracture during initial hospitalization
Authors: Fan WuQiang , Sun Xiaoxu , Leder Benjamin Z , Lee Hang , Ly Thuan V , Pu Charles T , Franco-Garcia Esteban , Bolster Marcy B 
Published: July 2024

Abstract
Inpatient zoledronic acid (IP-ZA) administered during the initial fracture hospitalization significantly improves the osteoporosis treatment rate. Clinical outcomes of IP-ZA after hip fracture remain uncertain. Here we report a cohort study that emulated a randomized controlled trial using real-world data and evaluated the risk of all-cause-mortality and radiologically confirmed subsequent new fractures among patients hospitalized for a hip fracture who had received IP-ZA as compared with propensity-matched controls. A total of 654 patients who had received IP-ZA and 6877 controls (for whom anti-osteoporosis treatment was indicated but no IP-ZA started during index hospitalization) were included in the study. The primary cohort comprised 652 IP-ZA patients (IP-ZA group) and 1926 matched controls (untreated group), with 71.7% female 92.1% White participants, with a mean age of 80.9 years. Cumulative all-cause mortality over the 24-month follow-up for the IP-ZA group was 12.3% and 20.7% for the untreated group (hazard ratio [HR], 0.62; 95% CI, 0.49-0.78, p &lt; .001). A total of 585 (89.7%) patients in IP-ZA group received only a single dose of ZA during the 24 months, and the death rate of this single dose group was 13.3%, which was significantly lower than that of the untreated group (HR, 0.70; 95% CI, 0.55-0.89, p = .003). Rates of radiologically confirmed cumulative subsequent new vertebral fractures were 2.0% in the IP-ZA group and 5.4% in the untreated group (HR, 0.40; 95% CI, 0.22-0.71, p = .001). A similarly lower rate of new vertebral fractures was seen in the single dose subgroup (1.9% vs 5.4%; HR, 0.44; 95% 0.24-0.82, p = .008). IP-ZA, administered during the initial hospitalization for hip fracture, was associated with lower all-cause-mortality and risk of radiologically confirmed subsequent new vertebral fractures, and thus offers a mechanism to narrow the treatment gap in patients having sustained a hip fragility fracture.
Frequency-focused sound data generator for fault diagnosis in industrial robots
Authors: Ahn Semin , Yoo Jinoh , Lee Kyu-Wha , Youn Byeng Dong , Ahn Sung-Hoon 
Published: July 2024

Abstract
A frequency-focused sound data generator was developed for the in situ fault sound diagnosis of industrial robot reducers. The sound data generator, based on a conditional generative adversarial network, selects a target frequency range without relying on domain knowledge. A sound dataset of normal and faulty harmonic drive rotations of in situ industrial robots was collected using an attachable wireless sound sensor. The generated sound data were evaluated based on the fault diagnosis accuracy of a simple classifier trained using the generated data and tested using real data. The proposed method well-defined the frequency feature clusters and produced high-quality data, exhibiting up to 16.0% higher precision score on normal and 13.0% higher accuracy on weak-fault harmonic drive compared with the conventional methods, achieving fault diagnosis accuracy of 95.6% even in situations of fault data comprising only 5% of the normal data.
Cold tolerance and metabolism of red-haired pine bark beetle Hylurgus ligniperda (Coleoptera: Curculionidae) during the overwintering period
Authors: Cheng Ling , Pei Jiahe , Chen Xuesong , Shi Fengming , Bao Zhashenjiacan , Hou Qidi , Zhi Lingxu , Zong Shixiang , Tao Jing 
Published: July 2024

Abstract
Hylurgus ligniperda invaded Shandong, China, through imported forest timber, posing a threat to China’s forest health. Exotic insects with broad environmental tolerance, including low temperatures, may have a better chance of surviving the winters and becoming invasive. Understanding the cold-tolerance strategies of H. ligniperda may help to design sustainable pest management approaches. In this study, we aim to investigate the cold-tolerance ability and relevant physiological indicators in overwintering H. ligniperda adults to determine any possible overwintering strategies. Supercooling points (SCPs) for adults H. ligniperda differed significantly across months and reached the lowest level in the mid- and post-overwintering period, the minimum SCPs −6.45 ± 0.18 °C. As the cold exposure temperature decreased, the survival rate of adults gradually decreased, and no adult survived more than 1 day at −15 °C, and the LLT50 for 1 day was −7.1 °C. Since H. ligniperda adults can survive internal ice formation, they are freeze-tolerant insects. Throughout the overwintering period, the SCPs and the water, protein, sorbitol, and glycerol content in adults decreased initially and then increased. We reported significant correlations between total protein, sorbitol, trehalose, and glycerol content in the beetles and SCPs. Glycogen, lipid, protein, trehalose, and sorbitol content in adult beetles may directly affect their cold-tolerance capacity and survival during winter. This study provides a physiological and biochemical basis for further study of metabolism and cold-tolerance strategies in H. ligniperda adults, which may help predict population dynamics and distribution potential of pests.
Tapping for love: courtship, mating, and behavioral asymmetry in two aphid parasitoids, Aphidius ervi and Aphidius matricariae (Hymenoptera: Braconidae: Aphidiinae)
Authors: Zeni Valeria , Romano Donato , Kavallieratos Nickolas G , Stefanini Cesare , Lucchi Andrea , Canale Angelo , Benelli Giovanni 
Published: July 2024

Abstract
Understanding the biology and ecology of parasitoids can have direct implications for their evaluation as biological control agents, as well as for the development and implementation of mass-rearing techniques. Nonetheless, our current knowledge of the possible influence of lateralized displays (i.e., the asymmetric expression of cognitive functions) on their reproductive behavior is scarce. Herein, we characterized the behavioral elements involved in courtship, and quantified the durations of 2 important aphid parasitoids, Aphidius ervi Haliday and Aphidius matricariae Haliday (Hymenoptera: Braconidae: Aphidiinae). We quantified the main indicators of copulation and examined the occurrence of lateralized traits at population level. Results indicated that A. matricariae exhibited longer durations of wing fanning, antennal tapping, pre-copula and copula phases compared to A. ervi. Postcopulatory behavior was observed only in A. matricariae. Unlike other parasitoid species, the duration of wing fanning, chasing, and antennal tapping did not affect the success of the mating of male A. ervi and A. matricariae. Both species exhibited a right-biased female kicking behavior at the population level during the pre-copula. Our study provides insights into the fundamental biology of aphidiine parasitoids and reports the presence of population-level lateralized mating displays, which can serve as useful benchmarks to evaluate the quality of mass-rearing systems.
Microclimatic drivers of winter bat activity in coast redwood forests
Authors: Andreozzi Chelsea L , Merenlender Adina M 
Published: July 2024

Abstract
Bats are among the least well-known mammals, particularly in terms of their behavior and activity patterns during the winter. Here, we use passive acoustic monitoring to overcome some of the challenges inherent in surveying cryptic forest bats during the wet season to quantify overwintering behavior for 11 species in California coast redwood forests under varying microclimates. Because different species are active at different forest heights, we also examined the effect of acoustic detector placement (treetop or ground level). Generalized linear mixed models were used to relate acoustic detection probability for 8 species to daytime and nighttime temperature, relative humidity, water vapor pressure, and detector placement. The results indicate that daytime maximum temperature best explained variation in nightly probability of detection, and temperature threshold at which bats were predicted to be detected varied considerably across species. By using more precise species detection methods, we were able to resolve significant differences in activity patterns between Myotis yumanensis and M. californicus, 2 species with similar acoustic signatures that are often lumped together. Myotis californicus was predicted to have a 50% probability of detection at maximum daytime temperature as low as 12.5 °C, whereas M. yumanensis was not predicted to have 50% detection probability until maximum daytime temperature was at least 22 °C, suggesting that M. californicus spends less time in torpor. Also, monitoring at the top of the canopy revealed 4 migratory species to be present in the ecosystem on significantly more monitoring nights than could be observed using conventional ground-based monitoring methods. Improving winter bat survey methods provides evidence that diverse bat species are more active in redwood forests during the winter than previously documented. This finding suggests that coastal forests could provide important winter bat habitat for both resident and migratory species.
Risk and related factors of elbow musculoskeletal diseases: a nationwide cross-sectional survey in China
Authors: Zhou Zhehua , Meng Pan , Jia Ning , Zhang Huadong , Ling Ruijie , Liu Yimin , Li Gang , Li Dongxia , Yin Yan , Shao Hua , Zhang Hengdong , Qiu Bing , Wang Dayu , Zeng Qiang , Chen Jianchao , Zhang Danying , Mei Liangying , Liu Yongquan , Liu Jixiang , Zhang Chengyun , Li Tianlai , Wang Zhongxu 
Published: July 2024

Abstract

Objectives
Although studies have shown that work-related musculoskeletal disorders (WMSDs) are common and continue to be a major source of disability and work time loss, there are few reports about elbow WMSDs. The aim of this study was to explore the prevalence and associated factors of elbow WMSDs.

Methods
The valid questionnaires of 57501 workers from 15 different industries nationwide were collected and the c2 test and logistic regression analysis were applied to reveal the prevalence and risk factors of elbow WMSDs.

Results
The findings indicated that the overall prevalence of elbow WMSDs among workers was 7.3%. However, the prevalence of elbow WMSDs in toy manufacturing was 21.3%, which was significantly higher than that in other industries (P &lt; .05). Logistic regression analysis showed that age 40 and above, married, very poor health, left-handedness, lifting weights (more than 20 kg each time), work requiring upper limb or hand force, work in an uncomfortable position, repetitive operations within 1 minute, using vibrating tools, work involving cold, cool draughts, or temperature changes, work being completed in the same workshop, work being done outdoors, frequent dealings with customers, 2 shifts, often working overtime, staff shortage, and often working for colleagues were risk factors for elbow WMSDs. A higer education level, monthly income, and enough rest time were protective factors for elbow WMSDs.

Conclusions
Toy manufacturing is a high-risk industry for elbow WMSDs. Promotion of education about ergonomics should be strengthened, and workers’ ergonomics awareness should be improved to reduce the impact of WMSDs.
The individual and work-related factors associated with the occupational future time perspective: a cross-sectional study of older workers in Japan
Authors: Sakai Kosuke , Nagata Tomohisa , Mori Takahiro , Sueyoshi Naozumi , Inoue Shunsuke , Odagami Kiminori , Shibata Yoshiyuki , Mori Koji 
Published: July 2024

Abstract

Objectives
Occupational future time perspective (OFTP) is important concept for a successful career in older workers. The purpose of this study was to examine the associations between individual and work-related factors and OFTP.

Methods
We conducted a cross-sectional study via an online questionnaire survey. Respondents were stratified sampled according to the distribution of workers across Japan. To assess OFTP, we used the Japanese version of the OFTP scale. We included factors such as sex, age, education, marital status, subjective health status, personal income, length of employment, industry, size of company, employment status, working days per week, and night shift. Multiple regression analysis was employed to calculate the regression coefficients for each factor, with OFTP serving as the dependent variable.

Results
In total we included 1484 respondents. Our findings indicated that higher OFTP was associated with higher education, better subjective health status, higher personal income, and smaller size of company. Compared with manufacturing, certain industries such as agriculture and forestry, transportation and postal services, and health care showed lower OFTP. In contrast to permanent workers, contract and part-time workers demonstrated lower OFTP, whereas owners of non–family businesses exhibited higher OFTP. Furthermore, individuals working 1-4 d/wk showed lower OFTP compared with those working 5 d/wk.

Conclusions
Older workers facing limitations in resources, such as educational background, personal income, precarious employment, and health status, tend to have lower OFTP. Such individuals should be given priority for support and assistance.