bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic relevance of aberrant SOCS‐1 gene promoter methylation in myelodysplastic syndromes patients
Authors: Chaubey R. , Sazawal S. , Mahapatra M. , Chhikara S. , Saxena R. 
Published: August 2014

SummaryIntroductionThe inactivation of suppressor of cytokine signaling SOCS‐1, a negative regulator of cytokine pathways, by hypermethylation was shown in hematological malignancies including Myelsplastic Syndromes. So far, its prognostic relevance in myelodysplastic syndromes (MDS) patients has not been understood.MethodsMethylation status of SOCS‐1 gene was analyzed in series of 100 patients using methylation‐specific PCR (MS‐PCR) and correlated with disease severity, progression, and survival by comparing prognostic factors such as hematological, clinical, and cytogenetics.ResultsOf the total of 100 MDS patients analyzed, methylation of SOCS1 gene was found in 53% patients. Also, the frequency of patients with poor and intermediate cytogenetics was observed significantly high in methylated group (P < 0.001). Moreover, the patients with methylated SOCS‐1 gene had significantly more frequent disease progression as compared to the patients with unmethylated SOCS‐1 gene (P < 0.006). Both progression‐free survival and median overall survival were significantly shorter in patients with methylated SOCS‐1 gene when compared to the patients with unmethylated SOCS‐1 gene (P = 0.006 & P = 0.001, respectively).ConclusionThis study for the first time showed that the mathylation of SOCS‐1 gene plays an important role in the disease progression and is associated with poor survival especially among the high‐risk patients. This may be due to high association between SOCS1 methylation and higher risk subtypes of MDS (such as RAEB) in this study.
Diagnosis and Treatment of Dynamic Collapse of the Cricotracheal Ligament in Thoroughbred Racehorses
Authors: Kelly Padraig G. , Pollock Patrick J. 
Published: August 2014

ObjectiveTo describe (1) diagnosis of dynamic collapse of the cricotracheal ligament in a group of horses and (2) treatment and outcome of affected horses.Study DesignRetrospective case series.AnimalsThoroughbred horses (n = 8).MethodsOf 600 over ground dynamic endoscopic examinations performed, 8 Thoroughbred horses had cricotracheal ligament collapse (CTLC); 5 were 2 years old and in early training and 2 were mature horses in full work. CTLC was diagnosed if circumferential collapse of the cricotracheal ligament was identified during exercise. Seven horses had repeat endoscopic examination. Two horses unresponsive to conservative management were treated surgically.ResultsMultiple abnormalities of the upper portion of the respiratory tract were identified along with CTLC in all five 2‐year‐old horses and resolution of CTLC was observed after treatment for upper airway inflammation. No concurrent respiratory abnormality was identified in the 2 mature horses. Surgical reduction of the cricotracheal space and imbrication of the cricotracheal ligament of these 2 horses resulted in resolution of clinical signs of CTLC.ConclusionsCTLC is a rare cause of dynamic obstruction in Thoroughbred racehorses. Resolution may occur after adaptation to training and after inflammation of the respiratory tract is resolved, but for horses with persistent CTLC, surgical reduction of the cricotracheal space and imbrication of the cricotracheal ligament may result in resolution of clinical signs.
The relationship between gender, perceived career barriers, and occupational aspirations
Authors: Watts Logan L. , Frame Mark C. , Moffett Richard G. , Van Hein Judith L. , Hein Michael 
Published: August 2014

AbstractThe relationships between college student gender, perceived career barriers, and occupational aspirations were examined. Participants were 314 students located in the southeastern United States. Overall, college women reported higher levels of occupational aspirations than college men. While occupational aspirations were not correlated with perceived career barriers for women or men, women reported anticipating more barriers to their career advancement than their male peers. Perceived career barriers and the interaction between gender and perceived career barriers predicted occupational aspirations after controlling for gender, socioeconomic status, ethnicity, and year in school. The relationship between occupational aspirations and the interaction between gender and perceived career barriers in college‐age adults enhances our understanding of occupational aspirations.
Arterial Stiffness and Wave Reflection 1 Year After a Pregnancy Complicated by Hypertension
Authors: Ehrenthal Deborah B. , Goldstein Neal D. , Wu Pan , Rogers Stephanie , Townsend Raymond R. , Edwards David G. 
Published: August 2014

Hypertensive disorders of pregnancy (HDP) are associated with cardiovascular disease (CVD) later in life. The authors investigated the association of HDP with blood pressure (BP) and arterial stiffness 1‐year postpartum. Seventy‐four participants, 33 with an HDP and 41 with uncomplicated pregnancies, were examined using applanation tonometry to measure BP, carotid‐femoral pulse wave velocity (cfPWV), and augmentation index (AIx). On average, women with HDP had a 9 mm higher systolic BP (P<.01), 0.8 m/s faster cfPWV (P=.09), and 5.4% greater AIx (P=.09) at the 1‐year examination. After adjustment for covariates, there was no significant difference in cfPWV between groups, while a 7.3% greater AIx (P<.05) remained. These findings suggest that reduced endothelial function may be detected 1 year after HDP. Large prospective studies are needed to further understand the contribution of arterial stiffness and endothelial dysfunction in the evolution of CVD after these complicated pregnancies.
Product Sustainability Index (ProdSI)
Authors: Shuaib Mohannad , Seevers Daniel , Zhang Xiangxue , Badurdeen Fazleena , Rouch Keith E. , Jawahir I.S. 
Published: August 2014

SummaryAs a result of the rapidly depleting global resources, continuing climate change and increasing environmental pollution, and the associated growth in customer awareness, improving product sustainability has become a global trend. Comprehensive sustainability assessment techniques are needed to assess a product's sustainability performance throughout its entire life cycle. This article presents the Product Sustainability Index (ProdSI) methodology and its application. This methodology is metrics based and provides a comprehensive assessment of the overall product sustainability throughout its total life cycle, covering the four life cycle stages: pre‐manufacturing; manufacturing; use; and postuse. In this article, first the fundamentals of sustainable manufacturing and product sustainability assessment (PSA) are presented, followed by a review of existing PSA methodologies. Major product sustainability elements that are used to define product sustainability clusters and individual sustainability metrics are then presented. Finally, theProdSImethodology for PSA, which follows a hierarchical approach for sustainability metrics identification and overall PSA, is introduced. The application of the methodology is demonstrated in a numerical example ofProdSIevaluation for two generations of a consumer electronics component.
Timing of UHP exhumation and rock fabric development in gneiss domes containing the world's youngest eclogite Facies rocks, southeastern Papua New Guinea
Authors: Korchinski M. S. , Vry J. , Little T. A. , Millet M.‐A. , Bicknell R. , Smith E. , von der Handt A. 
Published: August 2014

AbstractThe youngest known ultrahigh‐pressure (UHP) rocks in the world occur in the Woodlark Rift of southeastern Papua New Guinea. Since their crystallization in the Late Miocene to Early Pliocene, these eclogite facies rocks have been rapidly exhumed from mantle depths to the surface and today they remain in the still‐active geodynamic setting that caused this exhumation. For this reason, the rocks provide an excellent opportunity to study rates and processes of (U)HP exhumation. We present New Rb–Sr results from 12 rock samples from eclogite‐bearing gneiss domes in the D'Entrecasteaux Islands, and use those results to examine the time lag between (U)HP metamorphism and later ductile thinning, penetrative fabric development and accompanying metamorphic retrogression at amphibolite facies conditions during their exhumation. A Rb–Sr age for a sample of mafic eclogite (with no preserved coesite) from the core zone of the Mailolo gneiss dome (Fergusson Island) provides a new estimate of the timing of HP metamorphism (5.6 ± 1.6 Ma). The strongly deformed quartzofeldspathic and granitic gneisses (90–95% by volume) that enclose variably retrogressed relict blocks of mafic eclogite (5–10% by volume) yield Rb–Sr isochron ages from 4.4 to 2.4 Ma. For the UHP‐bearing gneisses of Mailolo dome, previously published U–Pb ages on zircon and our Rb–Sr isochron ages are consistent with a mean time lag of 2.2 ± 1.5 Ma (~95% c.i.) for passage of the rock between eclogite and amphibolite facies conditions. New thermobarometric data indicate that the main syn‐exhumational foliation developed at amphibolite facies conditions of 630–665 °C and 12.1–14.4 kbar. These pressure estimates indicate that the lower crust of the Woodlark Rift was unusually thick (>40 km) at the time of the amphibolite facies overprint, possibly as a result of accumulation and underplating of UHP‐derived material from below. Our data imply a minimum unroofing rate of 10 ± 7 mm year−1 (~95% c.i.) for the (U)HP body from minimum HP depths (73 ± 7 km) to lower crustal depths. This minimum unroofing rate reinforces previous inferences that the exhumation from the mantle to the surface of the gneiss domes in the D'Entrecasteaux Islands took place at plate tectonic rates. On the basis of previous structural studies and the new thermobarometry, we attribute the high (cm year−1) exhumation to diapiric ascent of the partially molten terrane from mantle depths, with a secondary contribution from pure shear thinning of the terrane after its arrival in the crust.
State‐Level School Competitive Food and Beverage Laws Are Associated With Children's Weight Status
Authors: Hennessy Erin , Oh April , Agurs‐Collins Tanya , Chriqui Jamie F. , Mâsse Louise C. , Moser Richard P. , Perna Frank 
Published: August 2014

ABSTRACTBACKGROUNDThis study attempted to determine whether state laws regulating low nutrient, high energy‐dense foods and beverages sold outside of the reimbursable school meals program (referred to as “competitive foods”) are associated with children's weight status.METHODSWe use the Classification of Laws Associated with School Students (CLASS) database of state codified law(s) relevant to school nutrition. States were classified as having strong, weak, or no competitive food laws in 2005 based on strength and comprehensiveness. Parent‐reported height and weight along with demographic, behavioral, family, and household characteristics were obtained from the 2007 National Survey of Children's Health. Bivariate and logistic regression analyses estimated the association between states' competitive food laws and children's overweight and obesity status (body mass index [BMI]‐for‐age ≥85th percentile). Children (N = 16,271) between the ages of 11‐14 years with a BMI for age ≥5th percentile who attended public school were included.RESULTSChildren living in states with weak competitive food laws for middle schools had over a 20% higher odds of being overweight or obese than children living in states with either no or strong school competitive food laws.CONCLUSIONState‐level school competitive food and beverage laws merit attention with efforts to address the childhood obesity epidemic. Attention to the specificity and requirements of these laws should also be considered.
School‐Level Factors Associated With Increased Fruit and Vegetable Consumption Among Students in California Middle and High Schools
Authors: Gosliner Wendi 
Published: August 2014

ABSTRACTBACKGROUNDThis study assessed associations between selective school‐level factors and students' consumption of fruits and vegetables at school. Better understanding of school factors associated with increased produce consumption is especially important, as students are served more produce items at school.METHODSThis cross‐sectional study included 5439 seventh‐ and ninth‐grade students from 31 schools in California in 2010. Multilevel regression models estimated whether the odds of consuming fruits or vegetables at school among students eating the school lunch were associated with the length of the lunch period, quality/variety of produce options, or other factors.RESULTSA longer lunch period was associated with increased odds of a student eating fruits (odds ratio [OR] = 1.40) and vegetables (OR = 1.54) at school. Better fruit quality increased the odds of a student consuming fruit (OR = 1.44). Including a salad bar and involving students in food service decisions increased a student's odds of consuming vegetables (OR = 1.48 and OR = 1.34, respectively).CONCLUSIONSThis study suggests that institutional factors in schools are positively associated with middle and high school students' consumption of produce items at school. Additional efforts to structure school meal environments to enhance students' consumption of produce items can benefit students' nutrition and health.
School Bus Crash Rates on Routine and Nonroutine Routes
Authors: O'Neal Elizabeth , Ramirez Marizen , Hamann Cara , Young Tracy , Stahlhut Mary , Peek‐Asa Corinne 
Published: August 2014

ABSTRACTBACKGROUNDAlthough prior research has established that school buses are a safe form of transportation, crashes can produce catastrophic consequences. School buses have 2 types of routes: predictable, routine routes that take children to and from school and less predictable, nonroutine routes for school events. No studies have examined school bus crash incidence and characteristics by these route types.METHODSSchool bus crashes were identified from the Iowa Department of Transportation Crash Database from mid‐2005 through mid‐2010. Crash reports did not identify whether the bus was on a routine or nonroutine route, so a protocol to assign these based on day and time was developed. Bus mileage was provided by the Iowa Department of Education.RESULTSThe school bus crash rate was 2.1 times higher on nonroutine routes than on routine routes (95% CI = 1.8‐2.3). Most crashes involved an improper action by the driver of another vehicle. In crashes attributed to improper actions of school buses, failure to yield the right‐of‐way and disregarding traffic signs were more common on routine routes, while losing control, speeding, reckless, or aggressive driving were more common on nonroutine routes.CONCLUSIONSSchool bus crashes are more likely to occur on nonroutine routes.
Protective effect of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide, a novel unsymmetrical divinyl sulfide, on an oxidative stress model induced by sodium nitroprusside in mouse brain: involvement of glutathione peroxidase activity
Authors: Ianiski Francine R , Alves Catiane B , Bassaco Mariana M , Silveira Claudio C , Luchese Cristiane 
Published: August 2014

Abstract

Objectives
In this study, the antioxidant action of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide, a novel unsymmetrical divinyl sulfide, against oxidative damage induced by sodium nitroprusside (SNP) in brains of mice was investigated.

Methods
Mice received SNP (0.335 μmol/site, intracerebroventricular) 30 min after administration of sulfide (10 mg/kg, intragastrically). After 1 h, animals were sacrificed and the brains were removed to biochemistry analysis. Thiobarbituric acid reactive species (TBARS), protein carbonyl (PC) and non-protein thiol (NPSH) levels, as well as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST) activities were determined.

Key findings
SNP increased TBARS and PC levels, CAT, GPx, GR and GST activities and reduced NPSH levels. Administration of the sulfide attenuated the changes produced by SNP and increased per se GPx activity in brains of mice. Toxicological parameters revealed that this compound did not cause acute renal or hepatic damage.

Conclusions
In conclusion, ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide protected against oxidative damage caused by SNP in mouse brain. GPx activity is involved, at least in part, in the cerebral antioxidant action of this compound.
Constrained k‐means on cluster proportion and distances among clusters for longitudinal data analysis
Authors: Usami Satoshi 
Published: August 2014

AbstractClustering individuals by measures of similarity or dissimilarity at trajectories of changes in longitudinal data enables determination of typical patterns of development and growth. The present research proposes a new constrained k‐means method with lower bound constraints on cluster proportions and distances among clusters at focused variables and time points to fulfill various needs in clustering longitudinal data. The method assumes a large number of clusters at the onset and iteratively deletes and combines clusters according to these constraints. An additional property of the proposed constrained k‐means includes direct estimation of the unknown number of clusters. Simulation results clearly show the usefulness of the method for extracting clusters in plausible, real‐life analysis including non‐normality within clusters, and the proposed algorithm works well and convergence of the estimates is satisfactory. An actual example using Japanese longitudinal data regarding sleep habits and mental health is presented to verify the utility of the proposed constrained k‐means.
Constructing initial phonology in Mandarin Chinese: Syllabic or subsyllabic? A masked priming investigation
Authors: Verdonschot Rinus G. , Lai Jun , Chen Feng , Tamaoka Katsuo , Schiller Niels O. 
Published: August 2014

AbstractRecent research has put forward the idea that Chinese speech production is governed by the syllable as the fundamental phonological unit. However, it may be that onset priming might be more difficult to obtain in Mandarin Chinese. Therefore, in this study, the degree of overlap between prime and target was increased from C to CV (i.e., extending beyond the phoneme) as well as whether primes and targets had an overlapping structure (CV vs. CVN). Subsyllabic priming effects were found (i.e., onset + vowel overlap but not purely onset overlap), contrasting with the claim that the syllable is the compulsory building block in the initial construction of Mandarin Chinese phonology.
Implementing a Medical Screening and Referral Program for Rural Emergency Departments
Authors: Menser Terri L. , Radcliff Tiffany A. , Schuller Kristin A. 
Published: August 2014

AbstractContextEmergency Department (ED) overcrowding due to nonemergent use is an ongoing concern. In 2011, a regional health system that primarily serves rural communities in Texas instituted a new program to medically screen and refer nonemergent patients to nearby affiliated rural health clinics (RHCs).PurposeThis formative evaluation describes the program goals, process, and early implementation experiences at 2 sites that adopted the program before wider implementation within the rural health system.MethodsPrimary data collection including document review, internal stakeholder interviews, and direct observation of program processes were used for this formative evaluation of program implementation in light of program goals and objectives. Fourteen key informants were asked questions related to the program concept, structure, and implementation.ResultsThe program, as implemented, aligned with initial program goals, but it was dependent on ED screening staff and RHC availability. Some adjustments to the program were needed, including RHC hours, consistency among staff in making referrals, patient education, and improving patient uptake on the referral. Stakeholders reported lessons learned related to training, staff buy‐in, Emergency Medical Treatment and Labor Act (EMTALA), and intraorganizational cooperation.DiscussionThe system was able to leverage excess capacity of affiliated RHCs to accommodate low‐acuity patients referred from the ED and may lead to improvements in Triple Aim goals of increased patient satisfaction, better population health and outcomes, and lower per capita costs. Lessons learned from this program may inform similar processes aimed to reduce nonemergency ED utilization by other rural health systems.
Electronic Medical Record Adoption in Oklahoma Practices: Rural‐Urban Differences and the Role of Broadband Availability
Authors: Whitacre Brian E. , Williams Randi S. 
Published: August 2014

AbstractPurposeMost recent research has not found significant differences in electronic medical record (EMR) adoption rates between rural and urban physicians. However, few studies have assessed rural/urban differences at a lower level—for instance, by specialty or size of practice. Determinants of EMR adoption by physician practices in Oklahoma are explored, including the potential role of broadband availability (which is required for EMR interoperability).MethodsSurveys of 2,800 unique Oklahoma physician practices in 2011 were meshed with data from the National Broadband Map for that same year. Summary statistics from the survey data allowed for comparison of EMR adoption rates by sub category. Logistic regressions were used to tease out the impact of location, specialty, and broadband availability on the EMR adoption decision.FindingsSimilar overall EMR adoption rates in rural and urban practices masked significant differences among specific subcategories. In particular, solo practices in rural areas are much more likely to adopt EMRs than are their urban counterparts (41% vs 33%, P < .01); rural psychiatric practices also have measurably higher adoption rates (59% vs 25%, P < .01). Logistic regression results demonstrate that determinants of adoption do vary between rural and urban practices. No statistical relationship between EMR adoption and measures of broadband availability was found.ConclusionsMeasurable differences in EMR adoption rates do exist between rural and urban practices for specific physician categories in Oklahoma. Targeted policies may be important for increasing EMR adoption, but policy efforts focusing solely on broadband availability for private practices are likely misguided.