bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of Percutaneous Tunneled Hemodialysis Catheter Procedures in Patients Receiving Concurrent Clopidogrel Therapy
Authors: Salazar Gloria Maria Martinez , Tan Chieh Suai , Spearman Kenneth , Wicky Stephen , Wu Steven 
Published: September 2013

Purpose Patients on clopidogrel are at increased risk of bleeding. This study was commenced to assess the incidence of bleeding in dialysis patients who underwent tunneled hemodialysis catheter procedures while on clopidogrel therapy. Methods This is a single center retrospective study of 25 (10 men, 15 women; median age 70) dialysis patients in whom clopidogrel could not be discontinued and underwent tunneled hemodialysis catheter insertion, removal or exchange between the period March 2010 to November 2011. The medical records of patients were reviewed and complications were classified according to the Society of Interventional Radiology system. Fifty-three procedures (22 insertions, 11 exchanges and 20 removals) were performed in these patients. The pre-procedural median platelet count, International Normalized Ratio and partial thromboplastin time were 195×103/dL (range 50-666), 1.1 (range 0.9-3.3) and 26.3 seconds (range 22.5-69.8) respectively. Results and Conclusions Forty-six procedures were performed in patients on clopidogrel and aspirin treatment. Five procedures were performed in patients while on clopidogrel in combination with aspirin and warfarin, and two procedures were performed with patients on clopidogrel alone. There were no documented bleeding complications from tunneled hemodialysis catheter procedures performed in patients on concurrent clopidogrel therapy in our study. Further prospective assessment with a larger cohort is necessary in order to validate these findings.
Isolation of Human Adipose-Derived Stromal Cells Using Laser-Assisted Liposuction and Their Therapeutic Potential in Regenerative Medicine
Authors: Chung Michael T. , Zimmermann Andrew S. , Paik Kevin J. , Morrison Shane D. , Hyun Jeong S. , Lo David D. , McArdle Adrian , Montoro Daniel T. , Walmsley Graham G. , Senarath-Yapa Kshemendra , Sorkin Michael , Rennert Robert , Chen Hsin-Han , Chung Andrew S. , Vistnes Dean , Gurtner Geoffrey C. , Longaker Michael T. , Wan Derrick C. 
Published: September 2013

Abstract
Harvesting adipose-derived stromal cells (ASCs) for tissue engineering is frequently done through liposuction. However, several different techniques exist. Although third-generation ultrasound-assisted liposuction has been shown to not have a negative effect on ASCs, the impact of laser-assisted liposuction on the quality and differentiation potential of ASCs has not been studied. Therefore, ASCs were harvested from laser-assisted lipoaspirate and suction-assisted lipoaspirate. Next, in vitro parameters of cell yield, cell viability and proliferation, surface marker phenotype, osteogenic differentiation, and adipogenic differentiation were performed. Finally, in vivo bone formation was assessed using a critical-sized cranial defect in athymic nude mice. Although ASCs isolated from suction-assisted lipoaspirate and laser-assisted lipoaspirate both successfully underwent osteogenic and adipogenic differentiation, the cell yield, viability, proliferation, and frequency of ASCs (CD34+CD31−CD45−) in the stromal vascular fraction were all significantly less with laser-assisted liposuction in vitro (p &lt; .05). In vivo, quantification of osseous healing by micro-computed tomography revealed significantly more healing with ASCs isolated from suction-assisted lipoaspirate relative to laser-assisted lipoaspirate at the 4-, 6-, and 8-week time points (p &lt; .05). Therefore, as laser-assisted liposuction appears to negatively impact the biology of ASCs, cell harvest using suction-assisted liposuction is preferable for tissue-engineering purposes.
Age of the Donor Reduces the Ability of Human Adipose-Derived Stem Cells to Alleviate Symptoms in the Experimental Autoimmune Encephalomyelitis Mouse Model
Authors: Scruggs Brittni A. , Semon Julie A. , Zhang Xiujuan , Zhang Shijia , Bowles Annie C. , Pandey Amitabh C. , Imhof Kathleen M.P. , Kalueff Allan V. , Gimble Jeffrey M. , Bunnell Bruce A. 
Published: September 2013

AbstractThere is a significant clinical need for effective therapies for primary progressive multiple sclerosis, which presents later in life (i.e., older than 50 years) and has symptoms that increase in severity without remission. With autologous mesenchymal stem cell therapy now in the early phases of clinical trials for all forms of multiple sclerosis (MS), it is necessary to determine whether autologous stem cells from older donors have therapeutic effectiveness. In this study, the therapeutic efficacy of human adipose-derived mesenchymal stem cells (ASCs) from older donors was directly compared with that of cells from younger donors for disease prevention. Mice were induced with chronic experimental autoimmune encephalomyelitis (EAE) using the myelin oligodendrocyte glycoprotein35–55 peptide and treated before disease onset with ASCs derived from younger (&lt;35 years) or older (&gt;60 years) donors. ASCs from older donors failed to ameliorate the neurodegeneration associated with EAE, and mice treated with older donor cells had increased central nervous system inflammation, demyelination, and splenocyte proliferation in vitro compared with the mice receiving cells from younger donors. Therefore, the results of this study demonstrated that donor age significantly affects the ability of human ASCs to provide neuroprotection, immunomodulation, and/or remyelination in EAE mice. The age-related therapeutic differences corroborate recent findings that biologic aging occurs in stem cells, and the differences are supported by evidence in this study that older ASCs, compared with younger donor cells, secrete less hepatocyte growth factor and other bioactive molecules when stimulated in vitro. These results highlight the need for evaluation of autologous ASCs derived from older patients when used as therapy for MS.
Entreprendre la flexicurité au niveau « méso » dans les PMO
Authors: Albert Cromarias Anne 
Published: September 2013

À l’heure où la flexicurité apparaît comme une façon de corriger les dérives liées aux mutations économiques et sociales, celle-ci, largement débattue sur le plan macroéconomique, commence à être envisagée sur le plan microéconomique. Or, pour l’appliquer aux petites et moyennes organisations (PMO), il semble pertinent de proposer une approche méso-organisationnelle, considérant des employeurs fonctionnant en réseau. La recherche s’intéresse, à travers une double lecture en termes de capital social et d’économie de la proximité, à un dispositif concret de flexicurité, pour comprendre et expliquer les modalités de sa mise en oeuvre.
Cet article interroge plus particulièrement le caractère entrepreneurial d’une démarche de flexicurité, initiée et mise en oeuvre dans un réseau de PMO, à la fois territorial et sectoriel, pour tenter d’identifier et de caractériser le rôle joué par les développeurs de ces projets.
Le secteur sportif apparaît particulièrement pertinent parce que confronté à des difficultés sociales importantes, notamment en termes de précarité de la main-d’oeuvre. Nous nous intéressons en particulier à l’Auvergne : le contrat d’objectifs du sport, récemment signé, encourage notamment la mutualisation des compétences en s’appuyant sur des exemples de groupements d’employeurs (GE). La recherche, mobilisant les outils de l’étude qualitative, s’inscrit dans le cadre d’une approche compréhensive et explicative du fonctionnement de ces GE et des acteurs qui les entourent.
Chaque porteur de projet semble agir comme un véritable « entrepreneur » de la flexicurité, tout à la fois pilote et facilitateur de sa mise en oeuvre, apparaissant ainsi comme le « révélateur » d’une proximité organisée entre employeurs.
Le marketing intégré en TPE
Authors: Albertini Thérèse , Fabiani Thierry 
Published: September 2013

La mise en oeuvre d’une démarche marketing traditionnelle, les prestations de conseils en management et a fortiori en mercatique entraînent très souvent une certaine réticence de la part des dirigeants de très petites entreprises (TPE). Pourtant, savoir apprécier son marché, apprendre à parler couramment le langage du client, procéder à l’évaluation de sa propre offre avec les yeux du client afin d’optimiser la proposition en fonction des segments de clientèle visés nous paraît essentiel. Cet article se propose de mettre à plat les mécanismes de compréhension des attentes clients afin de construire les réponses les plus appropriées et d’atteindre une performance durable. La présentation de la méthode du « parler courant client » (PCCL) est ici exposée par les deux auteurs sur la base de leurs expériences au contact de nombreuses PME et TPE.
La revue de la littérature viendra souligner les attentes des TPE dans le domaine marketing. L’étude empirique permettra, quant à elle, d’illustrer et de vérifier la pertinence du PCCL face aux attentes exprimées (accessibilité, transférabilité, simplicité, fidélisation de la clientèle existante).
Afin d’argumenter le propos, les auteurs s’appuieront ici sur trois exemples « fil rouge » (dont une TPE agroalimentaire installée en région Corse) et sur une enquête menée auprès des managers de TPE ayant suivi la formation PCCL dans le but d’instruire deux aspects : la présentation de la méthode PCCL ainsi que ses retombées (intérêt du chef d’entreprise pour cette méthode et mise en application de cette dernière). Nous verrons que le présent dispositif nécessite une approche méthodique autour de quatre étapes clés et qu’il existe de véritables avantages pour les entreprises qui sauront mettre en place ce dispositif.
La compétence relationnelle de l’entreprise
Authors: Gardès Nathalie , Maque Isabelle 
Published: September 2013

L’hypothèse d’opportunisme rend la relation banque-entreprise problématique. Cette relation nécessite alors de mettre en place des mécanismes permettant de pallier les risques inhérents à l’opportunisme potentiel des acteurs. La littérature met en avant l’intérêt des relations de long terme. Mais si la durée est nécessaire à l’apprentissage mutuel et au développement d’un capital confiance, celle-ci n’est pas suffisante pour inscrire la relation bancaire dans une approche relationnelle. Les intérêts financiers ne sont pas non plus suffisants comme principes d’organisation de la gestion des relations bancaires. Un niveau d’analyse supplémentaire est alors nécessaire pour comprendre les modalités de gestion de la relation bancaire. L’interaction sociale volontaire de l’entreprise cliente contribue alors à structurer la relation pour l’ancrer dans une gestion relationnelle. L’objectif de cet article est ainsi de montrer que le choix du mode de gestion de la relation bancaire, par l’entreprise cliente, permet de dépasser les analyses centrées sur les comportements opportunistes.
La méthodologie retenue est qualitative et la méthode utilisée est l’étude de cas. Toutes deux découlent du sujet étudié. L’étude présentée ici utilise les données de quatre études de cas menées auprès de quatre PME françaises. Les données sont secondaires. Ces études de cas ont été menées dans le cadre d’une recherche ayant pour objectif d’étudier le fonctionnement et l’organisation des relations banque(s)-entreprise du point de vue de l’entreprise.
Les quatre PME étudiées ont su développer une compétence relationnelle, d’une part, centrée sur une communication proactive et extensive et, d’autre part, axée sur la construction d’un espace rhétorique commun et la création de règles propres communes. Le développement de cette compétence relationnelle a permis la création d’un savoir, d’un savoir-faire et d’un savoir-être. L’analyse théorique centrée sur la gestion relationnelle des échanges bancaires et la pratique relationnelle des PME étudiées rendent non nécessaire la notion d’opportunisme.
The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development
Authors: Gagnier Joel J. , Kienle Gunver , Altman Douglas G. , Moher David , Sox Harold , Riley David 
Published: September 2013

Background: A case report is a narrative that describes, for medical, scientific, or educational purposes, a medical problem experienced by one or more patients. Case reports written without guidance from reporting standards are insufficiently rigorous to guide clinical practice or to inform clinical study design. Primary Objective: Develop, disseminate, and implement systematic reporting guidelines for case reports. Methods: We used a three-phase consensus process consisting of (1) premeeting literature review and interviews to generate items for the reporting guidelines, (2) a face-to-face consensus meeting to draft the reporting guidelines, and (3) postmeeting feedback, review, and pilot testing, followed by finalization of the case report guidelines. Results: This consensus process involved 27 participants and resulted in a 13-item checklist—a reporting guideline for case reports. The primary items of the checklist are title, key words, abstract, introduction, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up and outcomes, discussion, patient perspective, and informed consent. Conclusions: We believe the implementation of the CARE (CAse REport) guidelines by medical journals will improve the completeness and transparency of published case reports and that the systematic aggregation of information from case reports will inform clinical study design, provide early signals of effectiveness and harms, and improve healthcare delivery.
Racial Disparities in Sports Cardiology
Authors: Krishnan Sheela , Guseh James Sawalla , Chukumerije Merije , Grant Aubrey J. , Dean Peter N. , Hsu Jeffrey J. , Husaini Mustafa , Phelan Dermot M. , Shah Ankit B. , Stewart Katie , Wasfy Meagan M. , Capers Quinn , Essien Utibe R. , Johnson Amber E. , Levine Benjamin D. , Kim Jonathan H. ,   American College of Cardiology Sports & Exercise Leadership Council, Chung Eugene , Danielian Alfred , Dineen Beth 
Published: July 2024

ImportanceRacial disparities in cardiovascular health, including sudden cardiac death (SCD), exist among both the general and athlete populations. Among competitive athletes, disparities in health outcomes potentially influenced by social determinants of health (SDOH) and structural racism remain inadequately understood. This narrative review centers on race in sports cardiology, addressing racial disparities in SCD risk, false-positive cardiac screening rates among athletes, and the prevalence of left ventricular hypertrophy, and encourages a reexamination of race-based practices in sports cardiology, such as the interpretation of screening 12-lead electrocardiogram findings.ObservationsDrawing from an array of sources, including epidemiological data and broader medical literature, this narrative review discusses racial disparities in sports cardiology and calls for a paradigm shift in approach that encompasses 3 key principles: race-conscious awareness, clinical inclusivity, and research-driven refinement of clinical practice. These proposed principles call for a shift away from race-based assumptions towards individualized, health-focused care in sports cardiology. This shift would include fostering awareness of sociopolitical constructs, diversifying the medical team workforce, and conducting diverse, evidence-based research to better understand disparities and address inequities in sports cardiology care.Conclusions and RelevanceIn sports cardiology, inadequate consideration of the impact of structural racism and SDOH on racial disparities in health outcomes among athletes has resulted in potential biases in current normative standards and in the clinical approach to the cardiovascular care of athletes. An evidence-based approach to successfully address disparities requires pivoting from outdated race-based practices to a race-conscious framework to better understand and improve health care outcomes for diverse athletic populations.
Improving Pain Self-Management Among Rural Older Adults With Cancer
Authors: Shen Megan J. , Stokes Tammy , Yarborough Sarah , Harrison Jill 
Published: July 2024

ImportanceUndertreated cancer pain is a major public health concern among older adults in rural communities. Interventions to improve pain management among this vulnerable population are needed.ObjectiveTo test the feasibility, acceptability, and changes in pain outcomes from exposure to an adapted intervention, Cancer Health Empowerment for Living without Pain (CA-HELP), to improve patients’ communication about pain to their clinicians.Design, Setting, and ParticipantsOlder adults with cancer (aged ≥65 years) who were residing in a noninstitutional rural setting and receiving outpatient care at a rural-based clinic in Tennessee were enrolled in the study, in which everyone received the intervention, in May 2022. All patients were given assessments at baseline and 1 week after intervention. Mean score differences were analyzed using 1-tailed paired sample t tests (α = .05). Data were analyzed in June 2022.ExposureThe adapted version of CA-HELP included an 18-page patient-facing workbook and a 30-minute telephone coaching call with a registered nurse to coach patients on pain education and communication techniques to discuss pain with their medical team.Main Outcomes and MeasuresFeasibility was examined through accrual and completion rates. Acceptability was measured by helpfulness, difficulty, and satisfaction with the intervention. Changes in outcomes were measured using mean score differences from pre-post assessments of pain self-management, self-efficacy for communicating with clinicians about pain, patient-reported pain, and misconceptions about pain.ResultsAmong the 30 total participants, the mean (SD) age was 73.0 (5.1) years; 17 participants (56.7%) were female, 5 (16.7%) were Black or African American, 30 (100%) were non-Hispanic or non-Latino, 24 (80.0%) were White, 16 (53.3%) had less than a high school education, and 15 (50.0%) reported income less than $21 000 per year. Based on accrual and completion rates of 100%, this intervention was highly feasible. Fidelity rates for delivering intervention components (100%) and communication competence (27 participants [90%]) were also high. Regarding acceptability, all patients rated the intervention as helpful, with the majority (24 participants [80%]) rating it as “very helpful.” Most patients rated the intervention as “not at all difficult” (27 participants [90%]), enjoyed participating (21 participants [70%]), and reported being “very satisfied” (25 participants [83.3%]). Pre-post changes in outcomes suggested significant improvements in pain self-management and self-efficacy for communicating with clinicians about pain, as well as significant reductions in patient-reported pain and pain misconceptions.Conclusions and RelevanceIn this case-series study of CA-HELP, results suggested the adapted version of CA-HELP was feasible and acceptable and showed changes in pain-related outcome measures among older adults with cancer in a rural setting.
4‐Chloropyridine Hydrochloride
Authors: Bozinovic Nina S. 
Published: July 2024

image

[7379‐35‐3]

C
5
H
4
ClN·HCl

(MW 150.01)

InChI =
1S/C5H4ClN.ClH/c6‐5‐1‐3‐7‐4‐2‐5;/h1‐4H;1H

InChIKey =
XGAFCCUNHIMIRV‐UHFFFAOYSA‐N

(reagent is an HCl salt of 4‐chloropyridine, heterocyclic building block used in metal‐catalyzed cross‐coupling reactions, nucleophilic aromatic substitutions, and lithiations)

Alternative Name
: 4‐chloropyridinium chloride and
p
‐chloropyridine hydrochloride.

Physical Data
: mp 210 °C; flash point 198 °C – closed cup.

Form Supplied in
: beige‐yellow to white solid; widely available.

Solubility
: soluble in water.

Handling, Storage, and Precautions
: keep containers tightly closed in a dry, cool, and well‐ventilated place. Acute toxicity, oral (Category 4) H302, eye irritation (Category 2A) H319, and LD
50
oral (rat) 566 mg kg
−1
.

Preparative Methods
: the reagent is prepared by dehydroxy‐chlorination of 4‐pyridinol, deaminative chlorination or Sandmeyer chlorination of 4‐aminopyridine, and chlorination of pyridine
N
‐oxide.
Transformative learning about anxiety: A duo‐ethnography of Chinese female immigrants
Authors: Cui Dan , Li Xiaomei , Jin Wendi 
Published: July 2024

AbstractExisting studies predominantly analyze the mental health experiences of Chinese international students through a psychological perspective. This study, however, delves into transformative learning (TL) outcomes related to understanding and overcoming “anxiety” from a critical sociological lens. Utilizing a duo‐ethnographic methodology, it sheds light on the transformative learning experiences of three female Chinese researchers as they investigate anxiety in a North American higher education setting. This study uncovers socio‐cultural factors contributing to anxiety among Chinese international students abroad, with a particular emphasis on faculty's racialized habitus, academic struggles, emotions, and gender. It represents an interdisciplinary fusion between critical sociology and adult education, specifically concentrating on TL for social justice and the emotional and relational aspects of TL.
Fine Particulate Matter Components and Risk of Rheumatoid Arthritis: A Large General Canadian Open Cohort Study
Authors: Zhao Naizhuo , Smargiassi Audrey , Chen Hong , Widdifield Jessica , Bernatsky Sasha 
Published: July 2024

ObjectiveExposure to fine particulate matter (PM2.5) has been linked to many diseases. However, it remains unclear which PM2.5 chemical components for these diseases, including rheumatoid arthritis (RA), are more harmful. This study aimed to assess potential associations between PM2.5 components and RA and quantify the individual effects of each chemical component on RA risk.MethodsAn open cohort of 11,696,930 Canadian adults was assembled using Ontario administrative health data from January 2007 onward. Individuals were followed until RA onset, death, emigration from Ontario, or the end of the study (December 2019). Incident RA cases were defined by physician billing and hospitalization discharge diagnostic codes. The average levels of PM2.5 components (ammonium, black carbon, mineral dust, nitrate, organic matter, sea salt, and sulfate) for 5 years before cohort entry were assigned to participants based on residential postal codes. A quantile g‐computation and Cox proportional hazard models for time to RA onset were developed for the mixture of PM2.5 components and environmental overall PM2.5, respectively.ResultsWe identified 67,676 new RA cases across 130,934,256 person‐years. The adjusted hazard ratios for the time to RA onset were 1.027 and 1.023 (95% confidence intervals 1.021–1.033 and 1.017–1.029) per every decile increase in exposures to all seven components and per 1 μg/m3 increase in the overall PM2.5, respectively. Ammonium contributed the most to RA onset in the seven components.ConclusionExposure to PM2.5 components was modestly associated with RA risk. Public health efforts focusing on specific components (eg, ammonium) may be a more efficient way to reduce RA burden.