bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altering the Regioselectivity of a Nitroreductase in the Synthesis of Arylhydroxylamines by Structure‐Based Engineering
Authors: Bai Jing , Zhou Yong , Chen Qi , Yang Qing , Yang Jun 
Published: April 2015

AbstractNitroreductases have great potential for the highly efficient reduction of aryl nitro compounds to arylhydroxylamines. However, regioselective reduction of the desired nitro group in polynitroarenes is still a challenge. Here, we describe the structure‐based engineering of Escherichia coli nitroreductase NfsB to alter its regioselectivity, in order to achieve reduction of a target nitro group. When 2,4‐dinitrotoluene was used as the substrate, the wild‐type enzyme regioselectively reduced the 4‐NO2 group, but the T41L/N71S/F124W mutant primarily reduced the 2‐NO2 group, without loss of activity. The crystal structure of T41L/N71S/F124W and docking experiments indicated that the regioselectivity change (from 4‐NO2 to 2‐NO2) might result from the increased hydrophobicity of residues 41 and 124 (proximal to FMN) and conformational changes in residues 70 and 124.
Comparison of Different Polymer‐ and Silica‐Supported 9‐Amino‐9‐deoxy‐epi‐quinines as Recyclable Organocatalysts
Authors: Porta Riccardo , Coccia Francesca , Annunziata Rita , Puglisi Alessandra 
Published: April 2015

Abstract9‐Amino‐9‐deoxy‐epi‐quinine, properly modified by suitable linkers, was anchored on highly cross‐linked polystyrene, poly(ethylene glycol), and silica. The resulting species were characterized by NMR spectroscopy and tested as supported organocatalysts in the reaction between isobutyric aldehyde and trans‐β‐nitrostyrene. Polystyrene‐ and poly(ethylene glycol)‐supported catalysts outperformed their nonsupported counterpart affording the desired product in high yield and ee (>90 % ee). Silica‐supported catalysts proved to be less efficient in terms of both chemical yield and enantioselectivity. Polystyrene‐ and poly(ethylene glycol)‐supported 9‐amino‐9‐deoxy‐epi‐quinine were then used in the same reaction with different substrates, leading to the desired products in high yield and ee, as well as in three other reactions operating with different mechanism. An investigation of the recyclability of the polystyrene‐ and poly(ethylene glycol)‐supported systems showed that these could be recovered and recycled with no loss of stereochemical activity but with a marked erosion of chemical efficiency occurring at the fifth reaction cycle. This was ascribed to chemical degradation of the alkaloid occurring during the reaction.
Electrostatic Charge Measurements of Droplets of Various Liquids Falling over a Large Distance
Authors: Lüttgens Sylvia , Lüttgens Günter , Thulin Anders , Paillat Thierry , Touchard Gérard 
Published: April 2015

AbstractIn order to contribute to a better understanding of the electrostatic phenomena appearing during splash filling of liquids and to clarify the reasons why this process is suspected to increase static electrification especially due to atomization, accurate experiments of charge measurements were made on droplets of various liquids falling over a large distance (5 m). Eleven liquids of different conductivity and surface tension were tested. The results confirm that no charge evolution appears even over a long falling distance. A possible explanation of the static charge increase in splash filling is presented.
ChemInform Abstract: Crystal Structure of Type Alluaudite K0.4Na3.6Co(MoO4)3.
Authors: Nasri Rawia , Fakhar Bourguiba Noura , Zid Mohamed Faouzi 
Published: April 2015

AbstractK0.4Na3.6Co(MoO4)3 is prepared by solid‐state reaction of Na2CO3, Co(NO3)2, K2CO3, and (NH4)2Mo4O13 in the molar ratio of Na:K:Co:Mo = 2:1:3:3 (porcelain crucible, 963 K, 2 weeks; cooling to 910 K at a rate of 5 °C/d).
ChemInform Abstract: Crystal Structure of Magnesium Copper(II) Bis[orthophosphate(V)] Monohydrate.
Authors: Khmiyas Jamal , Assani Abderrazzak , Saadi Mohamed , El Ammari Lahcen 
Published: April 2015

AbstractSingle crystals of Mg1.65Cu1.35 (PO4)2·H2O are grown under hydrothermal conditions using an aqueous mixture of AgNO3, MgO, Cu, and H3PO4 (85 wt%) in the molar ratio of 1:4:4.5:6, resp.
ChemInform Abstract: Na2RE2TeO4(BO3)2 (RE: Y, Dy—Lu): Luminescent and Structural Studies on a Series of Mixed Metal Borotellurates.
Authors: Feng Jiang‐He , Hu Chun‐Li , Xu Xiang , Kong Fang , Mao Jiang‐Gao 
Published: April 2015

AbstractThe title compounds are prepared by solid state reactions of Na2CO3, TeO2, H3BO3, and Ln2O3 (Ln: Y, Dy—Lu; Pt crucible, 830 °C, 10 d).
ChemInform Abstract: [V@Ge8As4]3‐ and [Nb@Ge8As6]3‐: Encapsulation of Electron‐Poor Transition Metal Atoms.
Authors: Mitzinger Stefan , Broeckaert Lies , Massa Werner , Weigend Florian , Dehnen Stefanie 
Published: April 2015

AbstractThe title compounds are characterized by powder and single crystal XRD, electrospray ionization mass spectrometry, and DFT calculations.
ChemInform Abstract: Antimony‐Dependent Expansion for the Keggin Heteropolyniobate Family.
Authors: Zhang Zhe‐Yu , Peng Jun , Shi Zhen‐Yu , Zhou Wan‐Li , Khan Shifa Ullah , Liu Hong‐Sheng 
Published: April 2015

AbstractNine new Sb‐bicapped α‐Keggin‐type heteropolyoxoniobates are hydrothermally synthesized and characterized by single crystal XRD.
ChemInform Abstract: Chiral N‐Heterocyclic Carbene Ligands Bearing a Pyridine Moiety for the Copper‐Catalyzed Alkylation of N‐Sulfonylimines with Dialkylzinc Reagents.
Authors: Soeta Takahiro , Ishizaka Tomohiro , Tabatake Yuta , Ukaji Yutaka 
Published: April 2015

AbstractAmino acid‐derived chiral imidazolium salts, each bearing a pyridine ring, are developed as N—heterocyclic carbene ligands.
ChemInform Abstract: Difluorotris(pentafluoroethyl)phosphorane — A Highly Active Catalyst for Diels—Alder Reaction.
Authors: Bittner Bozena , Koppe Karsten , Bilir Vural , Frank Walter , Willner Helge , Ignat'ev Nikolai 
Published: April 2015

AbstractDifluorotris(pentafluoroethyl)phosphorane is shown to be a highly active catalyst for Diels—Alder reactions.
ChemInform Abstract: Intramolecular Metalloamination of N,N‐Dimethylhydrazinoalkenes: A Versatile Method to Access Functionalized Piperidines and Pyrrolidines.
Authors: Sunsdahl Bryce , Smith Adrian R. , Livinghouse Tom 
Published: April 2015

AbstractThe metalloamination (cyclization)/electrophilic functionalization (allylation, acylation) sequence proceeds with high diastereoselectivity.
ChemInform Abstract: Cu/Fe‐Cocatalyzed Meyer—Schuster‐Like Rearrangement of Propargylic Amines: Direct Access to E‐β‐Aminoacryaldehydes.
Authors: Chen Ming , Peng Jiangling , Mao Tingting , Huang Jinbo 
Published: April 2015

AbstractWhereas electronic effects do not influence the reaction efficiency, steric effects have a major impact, with 4‐substituted aryl amines providing the corresponding products in high yields, 3‐substituted aryl amines leading to moderate yields and 2‐substituted ones to only trace amounts of product.
ChemInform Abstract: A Robust and Efficient Catalyst Possessing an Electron‐Deficient Ligand for the Palladium‐Catalyzed Direct Arylation of Heteroarenes.
Authors: Jakab Alexandra , Dalicsek Zoltan , Soos Tibor 
Published: April 2015

AbstractA unique thermally and air stable Pd(0)‐triarylphosphine catalyst is applied for direct C—H arylation of electronically varied heterocycles with a variety of aryl bromides to give the corresponding biaryls generally in reasonable yields.
ChemInform Abstract: A Direct C—H Arylation of Unactivated Arenes Promoted by Mixed Potassium Alkoxides.
Authors: Wu Yinuo , Choy Pui Ying , Kwong Fuk Yee 
Published: April 2015

AbstractThe use of mixed alkoxides as base is the key to success for the direct arylation of benzene with aryl iodides.
ChemInform Abstract: Rhodium‐Catalyzed Intramolecular Dehydrogenative Aryl—Aryl Coupling Using Air as Terminal Oxidant.
Authors: Baars Hannah , Unoh Yuto , Okada Takeshi , Hirano Koji , Satoh Tetsuya , Tanaka Ken , Bolm Carsten , Miura Masahiro 
Published: April 2015

Abstractas an efficient route for construction of the fluorene framework
ChemInform Abstract: Synthesis of 2‐Substituted 3‐Alkylidene‐2,3‐dihydro‐1H‐isoindol‐1‐imines Through Cyclization of [1‐(2‐Cyanophenyl)alkylidene]aminide Intermediates Generated from the Reaction of 2‐(1‐Azidoalkyl)benzonitriles with NaH.
Authors: Kobayashi Kazuhiro , Ezaki Kosuke , Nozawa Ippei 
Published: April 2015

AbstractA convenient and simple route for the synthesis of a variety of the title compounds (IV) starting from readily available materials is developed.
ChemInform Abstract: Lithium tert‐Butoxide‐Mediated Carboxylation Reactions of Unprotected Indoles and Pyrroles with Carbon Dioxide.
Authors: Kobayashi Shu , Yoo Woo‐Jin , Nguyen Thanh V. Q. , Guiteras Capdevila Montse 
Published: April 2015

AbstractThe base‐mediated and transition metal‐free carboxylation reaction smoothly proceeds under ambient pressure of carbon dioxide with the use of a large excess of LiOtBu.
ChemInform Abstract: One‐Pot Synthesis of New Benzimidazole Derivatives Promoted by Potassium Carbonate.
Authors: Zhang Dun‐Lin , Xue Meng‐Wei , Zhou Hong , Yang Jing‐Jing , Li Jian , Liu Shao‐Xian 
Published: April 2015

AbstractAn efficient method for the synthesis of new benzimidazoline derivatives (IV) (18 examples) via a one‐pot three‐component reaction of phenylenediamines with aromatic aldehydes and Ar2O is given.
ChemInform Abstract: Copper‐Catalyzed Three‐Component Synthesis of Benzothiazolethiones from o‐Iodoanilines, Isocyanide, and Potassium Sulfide.
Authors: Dang Pan , Zeng Weilan , Liang Yun 
Published: April 2015

AbstractA simple procedure is elaborated for the conversion of o‐iodoanilines into benzothiazolethiones.
ChemInform Abstract: Synthesis and NMR Analysis of 1,4‐Disubstituted 1,2,3‐Triazoles Tethered to Pyridine, Pyrimidine, and Pyrazine Rings.
Authors: Bolje Aljosa , Urankar Damijana , Kosmrlj Janez 
Published: April 2015

AbstractCopper catalyzed 1,3‐dipolar cycloaddition of terminal alkynes and aromatic or benzylic azides containing different six‐membered aromatic N‐heteroaryl substituents is examined to yield a variety of 1,2,3‐triazoles with the expected regioselectivity.
ChemInform Abstract: Iodine‐Mediated Efficient Synthesis of Pyrano[2,3‐c]pyrazoles and Their Antimicrobial Activity.
Authors: Parshad Mahavir , Verma Vikas , Kumar Devinder 
Published: April 2015

AbstractReadily accessible pyrazolylchalcones (III) suffer an iodine‐mediated cyclization in DMSO leading to the title compounds (IV) in almost quantitative yield.
ChemInform Abstract: Stereoselective Aza‐Henry Reaction of Chiral tert‐Butanesulfinyl Imines with Methyl or Ethyl 4‐Nitrobutanoate: Easy Access to Enantioenriched 6‐Substituted Piperidine‐2,5‐diones.
Authors: Yus Miguel , Foubelo Francisco , Garcia‐Munoz M. Jesus 
Published: April 2015

AbstractBase‐catalyzed addition of 4‐nitrobutanoates to chiral aldimines (II) proceeds with high facial selectivity (84—96%) furnishing the β‐nitroamine derivatives (III), which can be easily converted into enantioenriched 6‐substituted piperidinediones (VI).
ChemInform Abstract: Synthesis of Fused Quinoline and Quinoxaline Derivatives Enabled by Domino Radical Triple Bond Insertions.
Authors: Sun Xiaoyang , Li Jiahong , Ni Yunpeng , Ren Daan , Hu Zhentao , Yu Shouyun 
Published: April 2015

AbstractThe visible light mediated domino radical isocyanide/alkyne insertion reaction gives access to a wide range of quinolines, quinoxalines, and heterocycles (XV).
ChemInform Abstract: Facile and Convenient Syntheses for Fluorine‐Containing Pyrazolo[4,3‐c]quinolines, Isoxazoloquinolines, and 1,4‐Diazepino[6,5‐c]quinolines
Authors: Okada Etsuji , Hatakenaka Mizuki , Sakaemura Takushi 
Published: April 2015

Abstractvia facile and convenient reaction of 4‐quinolylamine (I) with hydrazines, hydroxylamine and 1,2‐diamines, respectively
ChemInform Abstract: A Continuous‐Flow Synthesis of 1,4‐Benzodiazepin‐5‐ones, Privileged Scaffolds for Drug Discovery.
Authors: Viviano Monica , Milite Ciro , Rescigno Donatella , Castellano Sabrina , Sbardella Gianluca 
Published: April 2015

AbstractAn improved continuous‐flow synthetic method for the synthesis of benzodiazepinone derivatives (IV) is developed.
ChemInform Abstract: Construction of Nitrogen‐Containing 9‐Membered Ring Epoxy Vinyl Ethers via Gold(I)‐Catalyzed Intramolecular Cyclization Reactions of Acyclic 5‐Aza‐2,3‐epoxy‐7‐yn‐1‐ols.
Authors: Lin Hsin‐Hui , Chen Yi‐Ju , Liao Kuan‐Yu , Yeh Ming‐Chang P. 
Published: April 2015

AbstractThe attack of the alcohol functionality onto the gold(I)‐activated alkynes (II) leads to nine‐membered vinyl ether gold intermediates which undergo protodeauration furnishing the nine‐membered epoxy vinyl ethers (V).
ChemInform Abstract: Asymmetric Conjugate Addition of Grignard Reagents to 3‐Silyl Unsaturated Esters for the Facile Preparation of Enantioenriched β‐Silylcarbonyl Compounds and Allylic Silanes.
Authors: Zhao Kai , Loh Teck‐Peng 
Published: April 2015

AbstractA highly enantioselective conjugate addition of Grignard reagents to 3‐silyl unsaturated esters to deliver synthetically useful chiral β‐silylcarbonyl compounds is developed.
ChemInform Abstract: Secoeuphoractin, a Minor Diterpenoid with a New Skeleton from Euphorbia micractina
Authors: Xu Wen‐Dong , Tian Ye , Guo Qing‐Lan , Yang Yong‐Chun , Shi Jian‐Gong 
Published: April 2015

Abstractisolation, structure elucidation, biogenetic pathway and HIV‐1 replication inhibitory activity
ChemInform Abstract: Chemical Constituents of the Leaves of Desmos cochinchinensis var. fulvescens BAN
Authors: Wu Tung‐Ying , Cheng Yuan‐Bin , Cheng Fu‐Ting , Hsu Yu‐Ming , Tran Dinh Thang , Chang Fang‐Rong , Wu Yang‐Chang 
Published: April 2015

Abstractisolation and structure of two new compounds, 1β,7α‐dihydroxyeudesman‐4‐one (I) and 5αH‐megastigm‐7‐ene‐3α,4α,6.beta,9‐tetrol (II), along with nine known terpenoids
ChemInform Abstract: A New Steroidal Glycoside and Potential Anticancer Cytotoxic Activity of Compounds Isolated from the Bulbs of Lilium callosum.
Authors: Wang Xiao , Wu Guo Qing 
Published: April 2015

AbstractThe new steroidal glycoside, callosum A (I), is isolated along with five known steroidal glycosides from the butanol soluble fraction of Lilium callosum.
ChemInform Abstract: Eight New Polyketide Metabolites from the Fungus Pestalotiopsis vaccinii endogenous with the Mangrove Plant Kandelia candel (L.) Druce.
Authors: Liu Yonghong , et al.  
Published: April 2015

AbstractSeven new prenylated phenols, vaccinols A‐G [e.g. A (I) and C (II)], and one new naphthalene derivative, vaccinal A (III), are isolated together with five known phenol derivatives.
ChemInform Abstract: Cytotoxic, Antiinflammatory, and Antibacterial Sulfur‐Containing Polybromoindoles from the Formosan Red Alga Laurencia brongniartii.
Authors: Fang Hui‐Yu , Chiou Shu‐Fen , Uvarani Chokkalingam , Wen Zih‐Hong , Hsu Chi‐Hsin , Wu Yang‐Chang , Wang Wei‐Lung , Liaw Chih‐Chuang , Sheu Jyh‐Horng 
Published: April 2015

AbstractA new polybrominated indole (I) together with eleven known metabolites are isolated.
ChemInform Abstract: Three New Phthalides from Gnaphalium adnatum.
Authors: Zheng Xing‐Ping , Cui Qiong‐Fang , Zhao Jing‐Feng , Yang Li‐Juan , Zhang Hong‐Bin , Yang Xiao‐Dong , Li Liang 
Published: April 2015

Abstractisolation, structure elucidation, and antitumor activity of new phthalides, gnaphalides A‐C (I)‐(III)
ChemInform Abstract: Kinetico‐Mechanistic Studies on C—X (X = H, F, Cl, Br, I) Bond Activation Reactions on Organoplatinum(II) Complexes
Authors: Crespo Margarita , Martinez Manuel , Nabavizadeh S. Masoud , Rashidi Mehdi 
Published: April 2015

AbstractReview: 193 refs.
Variation in insurance status by patient demographics and tumor site among nonelderly adult patients with cancer
Authors: Grant Stephen R. , Walker Gary V. , Guadagnolo B. Ashleigh , Koshy Matthew , Allen Pamela K. , Mahmood Usama 
Published: April 2015

BACKGROUNDIn the United States, an estimated 48 million individuals live without health insurance. The purpose of the current study was to explore the Variation in insurance status by patient demographics and tumor site among nonelderly adult patients with cancer.METHODSA total of 688,794 patients aged 18 to 64 years who were diagnosed with one of the top 25 incident cancers (representing 95% of all cancer diagnoses) between 2007 and 2010 in the Surveillance, Epidemiology, and End Results (SEER) database were analyzed. Patient characteristics included age, race, sex, marital status, and rural or urban residence. County‐level demographics included percent poverty level. Insurance status was defined as having non‐Medicaid insurance, Medicaid coverage, or no insurance.RESULTSOn multivariate logistic regression analyses, younger age, male sex, nonwhite race, being unmarried, residence in counties with higher levels of poverty, and rural residence were associated with being uninsured versus having non‐Medicaid insurance (all P <.001). The highest rates of non‐Medicaid insurance were noted among patients with prostate cancer (92.3%), melanoma of the skin (92.5%), and thyroid cancer (89.5%), whereas the lowest rates of non‐Medicaid insurance were observed among patients with cervical cancer (64.2%), liver cancer (67.9%), and stomach cancer (70.9%) (P <.001). Among uninsured individuals, the most prevalent cancers were lung cancer (14.9%), colorectal cancer (12.1%), and breast cancer (10.2%) (P <.001). Lung cancer caused the majority of cancer mortality in all insurance groups.CONCLUSIONSRates of insurance coverage vary greatly by demographics and by cancer type. The expansion of health insurance coverage would be expected to disproportionally benefit certain demographic populations and cancer types. Cancer 2015;121:2020–2028. © 2015 American Cancer Society.
A small fully digital open‐loop clock and data recovery circuit for wired BANs
Authors: Derogarian Fardin , Ferreira João Canas , Tavares Vítor Grade 
Published: April 2015

SummaryThis paper proposes a new open‐loop and low complexity (small size) fast‐lock synchronization circuit for clock and data recovery in wearable systems. The system includes sensors embedded in textile and connected by conductive yarns. Synchronization is based on the open‐loop selection of the correct phase of the receiver clock synchronously with the incoming signal. The clock generator of the receiver is an autonomous oscillator set to operate at the same nominal frequency. The circuit lock time is at most one clock cycle, faster than all methods based on phase‐locked loops or delay‐locked loops. The circuit can be used for baseband communication independently of the signal coding method used in the physical layer, making it suitable for many applications. The fully digital circuit (including non‐return‐to‐zero inverted decoder) occupies 0.0022 in a 0.35 complementary metal‐oxide semiconductor (CMOS) process, a smaller implementation than many existing circuits, and supports a maximum system clock frequency of 70 for a 35‐data rate. Experimental results demonstrate that the proposed circuit robustly generates a synchronous clock for data recovery. The circuit is suitable for systems that tolerate some jitter but requires fast lock time, small size, and low energy consumption. Copyright © 2015 John Wiley & Sons, Ltd.
Spin Crossover in cis Manganese(III) Quinolylsalicylaldiminates
Authors: Sirirak Jitnapa , Harding David J. , Harding Phimphaka , Murray Keith S. , Moubaraki Boujemaa , Liu Lujia , Telfer Shane G. 
Published: April 2015

AbstractTwo new MnII/III redox pairs, [Mn(qsal‐Cl)2]0/+ 10/+ and [Mn(qsal‐Br)2]0/+ 20/+ have been synthesized employing the tridentate Schiff base ligands, 5‐X–N‐(8‐quinolyl)salicylaldimine (Hqsal‐X, X = Cl and Br). The neutral MnII complexes 1 and 2 were prepared from MnCl2 and Hqsal‐Cl and Hqsal‐Br while oxidation of 1 or 2 with AgOTf yields the cationic MnIII complexes, [Mn(qsal‐Cl)2]OTf, 1+, and [Mn(qsal‐Br)2]OTf, 2+. 1 and 2 have been characterized by single‐crystal X‐ray diffraction as CH2Cl2 solvates. The Mn centres adopt a strongly distorted octahedral geometry with cis O donors due to the pair of meridionally bound qsal‐X ligands. Electrochemical studies indicate two reversible one‐electron redox processes, Mn2+/3+ and Mn3+/4+. Spectroscopic studies show the LMCT bands move to lower wavelengths by ca. 30 nm while the νC=N stretches are little changed in the cationic complexes. Variable temperature magnetic susceptibility measurements indicate that 1+ and 2+ undergo gradual half spin crossover, despite having cis O donors. DFT calculations reveal a small HS–LS gap in the MnIII systems consistent with spin crossover and provide insight into the ligand design necessary for spin crossover in cis‐N4O2 MnIII compounds.
Ruthenium Carboxylate Complexes as Efficient Catalysts for the Addition of Carboxylic Acids to Propargylic Alcohols
Authors: Jeschke Janine , Gäbler Christian , Korb Marcus , Rüffer Tobias , Lang Heinrich 
Published: April 2015

AbstractRuthenium complexes [Ru(CO)2(PPh3)2(O2CR)2] – 3a (R = CH2OCH3), 3b (R = iPr), 3c (R = tBu), 3d (R = 2‐cC4H3O), and 3e (R = Ph) – were synthesized by treatment of Ru(CO)3(PPh3)2 with the corresponding carboxylic acids. The molecular structures of the newly synthesized complexes in the solid state are discussed. Compounds 3a–e were successfully applied as catalysts in the addition of carboxylic acids to propargylic alcohols to give the corresponding β‐oxo esters in good to excellent yields even in air. The different carboxylate ligands do not have an influence on the productivities, because the carboxylates exchange rapidly under the applied reaction conditions, as was confirmed by 31P{1H} NMR spectroscopic studies. The addition of catalytic amounts of Na2CO3 resulted in an increase in β‐oxo ester formation. The reaction is tolerant to the use of versatile functional groups on the propargylic alcohols and carboxylic acids, revealing a broad substrate generality. In contrast to most other known catalytic systems, even sterically hindered substrates, including 2,4,6‐trimethylbenzoic acid, 1,1‐diphenylprop‐2‐yn‐1‐ol, or the biologically active steroid ethisterone, were successfully converted.
Synthesis of Substituted γ‐ and δ‐Lactams through Mannich‐Type Reactions of Solid‐Supported N‐Acyliminium Ions
Authors: Komnatnyy Vitaly V. , Taveras Kennedy M. , Nandurkar Nitin S. , Le Quement Sebastian T. , Givskov Michael , Nielsen Thomas E. 
Published: April 2015

AbstractWe report the results of our recent investigations into the reactivity of cyclic solid‐supported N‐acyliminium ions. An intermolecular Mannich‐type transformation of these intermediates was used to generate libraries of substituted lactams. Masked aldehyde building blocks were readily prepared and coupled to peptides immobilized on PEGA800(polyethylene glycol dimethyl acrylamide) resin through an HMBA [4‐(hydroxymethyl)benzoic acid] linker. When treated with acid, the aldehyde was cleanly released and condensed with the amide backbone to form a hydroxylactam/N‐acyliminium ion, which underwent intermolecular reactions with a series of nucleophilic heterocycles, such as substituted indoles, thiophenes, furans, and electron‐rich benzenes. The resulting lactams were formed within a few minutes and in high purities (typically >85 %).