bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ability of Preseason Body Composition and Physical Fitness to Predict the Risk of Injury in Male Collegiate Hockey Players
Authors: Grant John A. , Bedi Asheesh , Kurz Jennifer , Bancroft Richard , Gagnier Joel J. , Miller Bruce S. 
Published: June 2014

Background: Injuries in collegiate ice hockey can result in significant time lost from play. The identification of modifiable risk factors relating to a player’s physical fitness allows the development of focused training and injury prevention programs targeted at reducing these risks. Purpose: To determine the ability of preseason fitness outcomes to predict in-season on-ice injury in male collegiate ice hockey players. Study Design: Prognostic cohort study. Level of Evidence: Level 3. Methods: Athlete demographics, percentage body fat, aerobic capacity (300-m shuttle run; 1-, 1.5-, 5-mile run), and strength assessment (sit-ups, push-ups, grip strength, bench press, Olympic cleans, squats) data were collected at the beginning of 8 successive seasons for 1 male collegiate ice hockey team. Hockey-related injury data and player-level practice/game athlete exposure (AE) data were also prospectively collected. Seventy-nine players participated (203 player-years). Injury was defined as any event that resulted in the athlete being unable to participate in 1 or more practices or games following the event. Multivariable logistic regression was performed to determine the ability of the independent variables to predict the occurrence of on-ice injury. Results: There were 132 injuries (mean, 16.5 per year) in 55 athletes. The overall injury rate was 4.4 injuries per 1000 AEs. Forwards suffered 68% of the injuries. Seventy percent of injuries occurred during games with equal distribution between the 3 periods. The mean number of days lost due to injury was 7.8 ± 13.8 (range, 1-127 days). The most common mechanism of injury was contact with another player (54%). The odds of injury in a forward was 1.9 times (95% CI, 1.1-3.4) that of a defenseman and 3 times (95% CI, 1.2-7.7) that of a goalie. The odds of injury if the player’s body mass index (BMI) was ≥25 kg/m2 was 2.1 times (95% CI, 1.1-3.8) that of a player with a BMI <25 kg/m2. The odds ratios for bench press, maximum sit-ups, and Olympic cleans were statistically significant but close to 1.0, and therefore the clinical relevance is unknown. Conclusion: Forwards have higher odds of injury relative to other player positions. BMI was predictive of on-ice injury. Aerobic fitness and maximum strength outcomes were not strongly predictive of on-ice injury.
Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation
Authors: Krejsgaard Thorbjørn , Willerslev-Olsen Andreas , Lindahl Lise M. , Bonefeld Charlotte M. , Koralov Sergei B. , Geisler Carsten , Wasik Mariusz A. , Gniadecki Robert , Kilian Mogens , Iversen Lars , Woetmann Anders , Odum Niels 
Published: June 2014

Key PointsStaphylococcal enterotoxins stimulate benign T cells to induce activation of the immunoregulatory Stat3/IL-10 axis in malignant T cells. Colonization with enterotoxin-producing Staphylococcus aureus may promote immune dysregulation in cutaneous T-cell lymphoma.
Elevated audiovisual temporal interaction in patients with migraine without aura
Authors: Yang Weiping , Chu Bingqian , Yang Jiajia , Yu Yinghua , Wu Jinglong , Yu Shengyuan 
Published: June 2014

Abstract

Background
Photophobia and phonophobia are the most prominent symptoms in patients with migraine without aura. Hypersensitivity to visual stimuli can lead to greater hypersensitivity to auditory stimuli, which suggests that the interaction between visual and auditory stimuli may play an important role in the pathogenesis of migraine. However, audiovisual temporal interactions in migraine have not been well studied. Therefore, our aim was to examine auditory and visual interactions in migraine.

Methods
In this study, visual, auditory, and audiovisual stimuli with different temporal intervals between the visual and auditory stimuli were randomly presented to the left or right hemispace. During this time, the participants were asked to respond promptly to target stimuli. We used cumulative distribution functions to analyze the response times as a measure of audiovisual integration.

Results
Our results showed that audiovisual integration was significantly elevated in the migraineurs compared with the normal controls (p < 0.05); however, audiovisual suppression was weaker in the migraineurs compared with the normal controls (p < 0.05).

Conclusions
Our findings further objectively support the notion that migraineurs without aura are hypersensitive to external visual and auditory stimuli. Our study offers a new quantitative and objective method to evaluate hypersensitivity to audio-visual stimuli in patients with migraine.
Assessment of laboratory methods used in the diagnosis of congenital toxoplasmosis after maternal treatment with spiramycin in pregnancy
Authors: Rodrigues Isolina MX , Costa Tatiane L , Avelar Juliana B , Amaral Waldemar N , Castro Ana M , Avelino Mariza M 
Published: June 2014

AbstractBackgroundThe different laboratory methods used in the diagnosis of congenital toxoplasmosis have variable sensitivity and specificity. There is no evidence to prove that maternal treatment reduces the risk of fetal infection. The purpose of this study was to assess methods for the confirmation of congenital toxoplasmosis after maternal treatment with spiramycin during pregnancy, and to evaluate the effect of this treatment on clinical manifestations of the disease in newborns (NB).MethodsThis was a community-based, cross-sectional study of acute toxoplasmosis in newborns at risk of acquiring congenital infection. Participating newborns were born in the Clinical Hospital Maternity Ward of the Federal University of Goiás. Eligible participants were divided into 2 groups: group 1 consisted of 44 newborns born to mothers treated with spiramycin during pregnancy and group 2 consisted of 24 newborns born to mothers not treated with spiramycin during pregnancy because the diagnosis of toxoplasmosis was not performed. The sensitivity and specifity of PCR forT. gondiiDNA in peripheral blood and serological testing for specific anti-T. gondiiIgM and IgA, and the effects of maternal spiramycin treatment on these parameters, were determined by associating test results with clinical manifestations of disease.ResultsThe sensitivity of the markers (T. gondiiDNA detected by PCR, and the presence of specific anti-T. gondiiIgM and IgA) for congenital toxoplasmosis was higher in group 2 than in group 1 (31.6, 68.4, 36.8% and 3.7, 25.9, 11.1% respectively). Even with a low PCR sensitivity, the group 2 results indicate the importance of developing new techniques for the diagnosis of congenital toxoplasmosis in newborns. Within group 1, 70.4% of the infected newborns were asymptomatic and, in group 2, 68.4% showed clinical manifestations of congenital toxoplasmosis.ConclusionsThe higher proportion of infants without clinical symptoms in group 1 (70.4%) suggests the maternal treatment with spiramycin delays fetal infection, reducing the clinical sequelae of the disease in newborns. Given the low sensitivity of the tests used, when there is suspicion of congenital transmission several serological and parasitological tests are required in order to confirm or exclude congenital toxoplasmosis in newborns.
Preparation of γ-Fe2O3/ZnFe2O4nanoparticles by enhancement of surface modification with NaOH
Authors: Chen Longlong , Li Jian , Lin Yueqiang , Liu Xiaodong , Li Junming , Gong Xiaomin , Li Decai 
Published: June 2014

Abstract

Background
During liquid-phase synthesis of γ-Fe2O3 nanoparticles by chemically induced transition in FeCl2 solution, enhancement of surface modification by adding ZnCl2 was attempted by using NaOH. By using transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectrometry, and vibrating sample magnetometry, the dependence of the synthesis on the amount of additional NaOH was studied.

Results
The experimental results show that the surface of the γ-Fe2O3 nanoparticles could be modified by adding ZnCl2 to form composite nanoparticles with γ-Fe2O3/ZnFe2O4 ferrite core coated with Zn(OH)2 and adsorbed FeCl3, and that modification could be enhanced by adding NaOH.

Conclusions
In the experimental conditions, when the concentration of additional NaOH was below 0.70 M, the amounts of ZnFe2O4 and Zn(OH)2 phases increased slightly and that of adsorbed FeCl3 was unchanged. When the concentration of NaOH exceeded 0.70 M, the amount of FeCl3, ZnFe2O4, and Zn(OH)2 increased.
Optimization of biomass and biokinetic constant in Mazut biodegradation by indigenous bacteria BBRC10061
Authors: Khorasani Alireza Chackoshian , Mashreghi Mansour , Yaghmaei Soheila 
Published: June 2014

AbstractOptimization based on appropriate parameters can be applied to improve a process. Mazut degradation as a critical issue in environment requires optimization to be efficiently done. To provide biodegradation conditions, experiments were designed on the least interactions among levels of parameters consisting of pH, Tween 80, glucose, phosphorous source, nitrogen source, and time. Kinetic constants and biomass were calculated based on 16 assays, designed using Taguchi method, which constructed various mazut biodegradation conditions. Kinetics of mazut degradation by newly isolated bacteriaEnterobacter cloacaeclosely followed second order kinetic model. Results of the 16 experiments showed that biomass was in the range of 0.019 OD600to 2.75 OD600, and biokinetic constant was in the range of 0.2 × 10-5 L/ (mg day) to 10-4 L/ (mg day). Optimal level for each parameter was obtained through data analysis. For optimal biomass equal to 2.75 OD600, optimal pH, Tween80, glucose, phosphorous source, and time were 8.3, 4 g/L, 4 g/L, 9 g/L, and 10 days, respectively. For biokinetic constant equal to 1.2 × 10-4 L/ (mg day), optimal pH, Tween80, glucose, phosphorous source, and nitrogen source were 8.3, 1 g/L, 4 g/L, 1 g/L, and 9 g/L, respectively. The optimum levels for biomass and biokinetic constant were the same except the levels of the Tween 80, and phosphorous source. Consequently, mazut may be more degraded with adjusting the conditions on the optimum condition.
Assessment of Potential Biomarkers of Subclinical Vitamin K Deficiency in Patients with End-Stage Kidney Disease
Authors: Elliott Meghan J , Booth Sarah L , Hopman Wilma M , Holden Rachel M 
Published: June 2014

Background: A significant proportion of hemodialysis patients have functional, but modifiable, vitamin K deficiency. Objective: To determine the correlates of poor vitamin K status in hemodialysis patients. Design: Cross-sectional study. Setting: Hemodialysis units at Kingston General Hospital and its satellite centres, Ontario, Canada. Patients: Patients undergoing outpatient hemodialysis for end-stage kidney disease. Measurements: Serum concentrations of phylloquinone, undercarboxylated prothrombin, also known as protein induced by vitamin K absence or antagonism – factor II (PIVKA-II), and the percentage of undercarboxylated osteocalcin (%ucOC). Methods: Vitamin K status was determined in fasting blood samples of hemodialysis patients. Bivariate relationships were examined using parametric and non-parametric statistics as appropriate. Multivariable linear regression models were applied to identify predictors of vitamin K status. Results: Among 44 HD patients, criteria for subclinical vitamin K deficiency were met in 13.6% (phylloquinone < 0.4 nmol/L), 51% (%ucOC > 20%) and 90.9% (PIVKA-II > 2.0 nmol/L) of subjects. Phylloquinone levels were positively associated with total cholesterol, triglyceride levels and non-smoking status. Higher %ucOC was associated with increased calcium-phosphate product. Increased PIVKA-II levels were observed with advancing age, reduced dialysis adequacy, lower HDL and a history of coronary artery disease. There were no associations found among the individual biomarkers of vitamin K status. In a multi-variable model, triglycerides were the only significant predictor of phylloquinone levels, while increasing phosphate and decreasing PTH were independent predictors of %ucOC. PIVKA-II levels increased by 0.54 nmol/L for every 10-year increase in age. Limitations: Observational study; small sample size. Conclusions: A significant proportion of HD patients met criteria for subclinical vitamin K deficiency. Of the biomarkers measured, PIVKA-II may be superior given its independence of renal function or dyslipidemia, both of which may confound the other vitamin K biomarkers. Studies in patients with ESKD linking biomarkers of vitamin K status to important patient outcomes, including cardiovascular disease, nutritional status and mortality, are required in order to determine the optimal biomarker for evaluating vitamin K status in this particular population.
Symptomatic loosening of a total knee arthroplasty caused by a tibial chondrosarcoma – a case report
Authors: Sieker Jakob T , Rudert Maximilian , Steinert Andre F 
Published: June 2014

Abstract
Premature implant loosening following total knee arthroplasty (TKA) can have several causes. In this article we report on a rare case of a 74 year old male patient suffering tibial component loosening 14 month after primary TKA. The patient did neither have any malignancies nor joint arthroplasty before. Upon clinical examination the range of motion in the diseased knee was painfully restricted to 80° of knee flexion, with the patient increasingly suffering sleeping and resting pain, and also at weight bearing. In standard radiographs, loosening of the TKA due to a large osteolysis at the tibial component was evident. Local computed tomography (CT) of the right knee revealed loosening of the tibial component due to a presumably malign bone tumor. For determination of the final diagnosis a representative biopsy of the tumor was taken by open surgery prior to the tumor resection. Histopathologic evaluation of the biopsy revealed a periprosthetic myxoid chondrosarcoma of the proximal tibia. Pre-operative staging examination included CT scans of lung and abdomen, as well as a bone scintigraphy which revealed no signs of tumor metastasis in the body. Surgical management comprised wide tumor resection and implantation of a hinged tumor knee arthroplasty with replacements of the distal femur and proximal tibia, as well as a patella tendon replacement using a synthetic ligament. Revision surgery was necessary twice due to impaired wound healing and critical soft tissue coverage, and treatment included a gastrocnemius muscle flap with skin mesh graft covering. Unfortunately long-term follow-up examinations could not be obtained, as the patient deceased due to an alveolitis during rehabilitation. In summary, the specifics of this rare case of aseptic TKA loosening, and the unusual circumstances of chondrosarcoma diagnosis and treatment are informative for those providing surgical treatment of similar cases.
Aberrant DNA methylation patterns in diabetic nephropathy
Authors: Maghbooli Zhila , Larijani Bagher , Emamgholipour Solaleh , Amini Manochehr , Keshtkar Abbasali , Pasalar Parvin 
Published: June 2014

Abstract
Background
The aim of this study was to evaluate whether global levels of DNA methylation status were associated with albuminuria and progression of diabetic nephropathy in a case-control study of 123 patients with type 2 diabetes- 53 patients with albuminuria and 70 patients without albuminuria.

Methods
The 5-methyl cytosine content was assessed by reverse phase high pressure liquid chromatography (RP-HPLC) of peripheral blood mononuclear cells to determine individual global DNA methylation status in two groups.

Results
Global DNA methylation levels were significantly higher in patients with albuminuria compared with those in normal range of albuminuria (p = 0.01). There were significant differences in global levels of DNA methylation in relation to albuminuria (p = 0.028) and an interesting pattern of increasing global levels of DNA methylation in terms of albuminuria severity.
In patients with micro- and macro albuminuria, we found no significant correlations between global DNA methylation levels and duration of diabetes (p > 0.05). In both sub groups, there were not significant differences between global DNA methylation levels with good and poor glycaemic control (p > 0.05). In addition, in patients with albuminuria, no differences in DNA methylation levels were observed between patients with and without other risk factors including age, gender, hypertension, dyslipidaemia and obesity.

Conclusions
These data may be helpful in further studies to develop novel biomarkers and new strategies for clinical care of patients at risk of diabetic nephropathy.
The impact of gout on patient’s lives: a study of African-American and Caucasian men and women with gout
Authors: Singh Jasvinder A 
Published: June 2014

Abstract
Introduction
The aim of this study was to examine the impact of gout on quality of life (QOL) and study differences by gender and race.

Methods
Ten race- and sex-stratified nominal groups were conducted, oversampling for African-Americans and women with gout. Patients presented, discussed, combined and rank-ordered their concerns.

Results
A total of 62 patients with mean age 65.1 years, 60% men, 64% African-American, participated in 10 nominal groups: African-American men (n = 23; 3 groups); African-American women (n = 18; 3 groups); Caucasian men (n = 15; 3 groups); and Caucasian women (n = 6; 1 group). The most frequently cited high-ranked concerns among the ten nominal groups were: (1) effect of gout flare on daily activities (n = 10 groups); (2) work disability (n = 8 groups); (3) severe pain (n = 8 groups); (4) joint swelling and tenderness (n = 6 groups); (5) food restrictions (n = 6 groups); (6) medication related issues (n = 6 groups); (7) dependency on family and others (n = 5 groups); (8) emotional Impact (n = 5 groups); (9) interference with sexual function (n = 4 groups); (10) difficulty with shoes (n = 4 groups); and (11) sleep disruption (n = 4 groups). Compared with men, women ranked the following concerns high more often: problems with shoes (n = 4 versus n = 0 groups); dependency (n = 3 versus n = 2 groups); and joint/limb deformity (n = 2 versus n = 0 group). Compared with Caucasians, African-Americans ranked the following concerns high more often: dietary restrictions (n = 6 versus n = 0 groups); severe pain (n = 6 versus n = 2 groups); gout bringing the day to a “halt” (n = 2 versus n = 0 group); effect on emotional health (n = 4 versus n = 1 groups); and the need for canes/crutches during flares (n = 2 versus n = 0 group).

Conclusions
Gout has a significant impact on a patient’s QOL. Important differences in the impact of gout by gender and race were noted.
Persistent inflammation and T cell exhaustion in severe sepsis in the elderly
Authors: Inoue Shigeaki , Suzuki Kodai , Komori Yukako , Morishita Yukiko , Suzuki-Utsunomiya Kyoko , Hozumi Katsuto , Inokuchi Sadaki , Sato Takehito 
Published: June 2014

Abstract
Introduction
Sepsis is known as a complex immunological response with hyperinflammation in the acute phase followed by immunosuppression. Although aging is crucial in sepsis, the impact of aging on inflammation and immunosuppression is still unclear. The purpose of this study was to investigate the relationship between inflammation and immunosuppression in aged patients and mice after sepsis.

Methods
Fifty-five patients with severe sepsis and 30 healthy donors were prospectively enrolled, and 90-day survival was compared between elderly (≥65 years) and adult (18–64 years) septic patients with serial measurement of serum interleukin (IL)-6. Within 24 h after diagnosis of severe sepsis, peripheral blood mononuclear cells were stimulated ex vivo to measure expression of the activation maker CD25 in T cells, IL-2 levels in the supernatant, and proliferation. In the mouse study, young (6–8 weeks) and aged (20–22 months) C57/B6 mice were subjected to cecal ligation and puncture (CLP), and survival was compared after 7 days with serial measurement of serum IL-6. Expression of the negative co-stimulatory molecules, CD25, and IL-2 in CD4+ T cells was measured.

Results
The survival rate in elderly sepsis patients and aged septic mice was significantly lower than that in adult patients and young septic mice (60% vs. 93% in septic patients, 0% vs. 63% in septic mice, P < 0.05). Serum IL-6 levels in elderly sepsis patients and aged septic mice were persistently higher than those in adult patients and young septic mice. Expression of negative co-stimulatory molecules in CD4+ T cells in the spleen, lymph nodes, and peripheral blood was significantly higher in aged mice than in young mice (P < 0.01). Ex vivo stimulation decreased CD25 expression, IL-2 production, and proliferation to a greater extent in CD4+ T cells from elderly patients and aged septic mice than in those from adult patients and young septic mice. Elderly patients demonstrated increased detection of gram-negative bacteria at days 14–16 and 28–32 after sepsis (P < 0.05).

Conclusions
Persistent inflammation and T cell exhaustion may be associated with decreased survival in elderly patients and mice after sepsis.
Credit off-take from formal financial institutions in rural India: quantile regression results
Authors: Pal Debdatta , Laha Arnab Kumar 
Published: June 2014

AbstractExtending financial services to unbanked population in India has remained a central part of the policy thrust of the Indian government for decades. To that effect, a widespread formal credit delivery mechanism has been established to meet the credit requirements of rural communities. However, the Indian government-backed formal financial sector has had limited success in providing resources to poor rural households, which has led to strong criticism of the policy and its implementation. In this study, we use data from 600 rural households spread across six Indian states to examine the changing distribution of credit off-take among borrowers of formal financial institutions. By using quantile regression, we find that even among rural households that could access loans from the formal banking sector, the distribution of credit off-take is skewed towards resource-rich households. We also find that even among borrowers in the upper quantiles of the conditional loan distribution, marginal farmers received substantially less loan amounts than those belonging to the category of medium and large farmers.JEL classificationsC31, Q14