bluuebunny/crossref_metadata_2025_split huggingface dataset:
Everolimus Plus Octreotide Long-Acting Repeatable in Patients With Colorectal Neuroendocrine Tumors: A Subgroup Analysis of the Phase III RADIANT-2 Study
Authors: Castellano Daniel , Bajetta Emilio , Panneerselvam Ashok , Saletan Stephen , Kocha Walter , O'Dorisio Thomas , Anthony Lowell B. , Hobday Timothy ,   RADIANT-2 Study Group
Published: December 2012

AbstractIntroduction.The incidence of colorectal neuroendocrine tumors (NETs) is increasing, and patients with this disease have particularly poor prognoses. Treatment options are limited, and survival times have not improved in the past decade.Methods.A post hoc analysis of the efficacy and tolerability of everolimus plus octreotide long-acting repeatable (LAR) was conducted in patients with colorectal NETs enrolled in the phase III RAD001 in Advanced Neuroendocrine Tumors, Second Trial (RADIANT-2) study. The primary endpoint (progression-free survival [PFS]), secondary endpoints (including objective response rate), and safety were assessed.Results.Patients with colorectal NETs receiving everolimus plus octreotide LAR had a significantly longer median PFS (29.9 months; n = 19) than did those receiving placebo plus octreotide LAR (6.6 months; n = 20). Everolimus plus octreotide LAR treatment also significantly reduced the risk for disease progression (hazard ratio: 0.34; 95% confidence interval: 0.13–0.89; p = .011). Although no objective responses were observed, tumor shrinkage was more frequently noted in the everolimus plus octreotide LAR arm than in the placebo plus octreotide LAR arm (67% vs. 37%, respectively). The combination of everolimus plus octreotide LAR was generally well tolerated by patients with colorectal NETs; rash and stomatitis were the most commonly reported adverse events.Conclusions.Everolimus plus octreotide LAR treatment had significant benefits and improved outcomes for patients with advanced colorectal NETs compared with placebo plus octreotide LAR treatment. Results of this exploratory analysis are consistent with those reported from the RADIANT-2 primary analysis. These findings support additional investigations of everolimus plus octreotide LAR in patients with colorectal NETs.
Elderly Postmenopausal Patients With Breast Cancer Are at Increased Risk for Distant Recurrence: A Tamoxifen Exemestane Adjuvant Multinational Study Analysis
Authors: Van De Water Willemien , Seynaeve Caroline , Bastiaannet Esther , Markopoulos Christos , Jones Steve E. , Rea Daniel , Hasenburg Annette , Putter Hein , Hille Elysée T.M. , Paridaens Robert , de Craen Anton J.M. , Westendorp Rudi G.J. , Van De Velde Cornelis J.H. , Liefers Gerrit-Jan 
Published: December 2012

Abstract

Introduction.
For postmenopausal patients with hormone-sensitive breast cancer, outcome is worse with increasing age at diagnosis. The aim of this study was to assess the incidence of breast cancer recurrence (locoregional and distant), and contralateral breast cancer by age at diagnosis.

Methods.
Patients enrolled in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial were included. Primary endpoints were locoregional recurrence, distant recurrence, and contralateral breast cancer. Age at diagnosis was categorized as younger than 65 years, 65–74 years, and 75 years or older.

Results.
Overall, 9,766 patients were included, of which 5,349 were younger than 65 years (reference group), 3,060 were 65–74 years, and 1,357 were 75 years or older. With increasing age, a decreased administration of radiotherapy after breast conserving surgery (94%, 92%, and 88%, respectively) and adjuvant chemotherapy (51%, 23%, and 5%, respectively) was observed. Risk of distant recurrence increased with age at diagnosis; multivariable hazard ratio for patients aged 65–74 years was 1.20 (95% confidence interval [CI]: 1.00–1.44), hazard ratio for patients aged 75 years or older was 1.39 (95% CI: 1.08–1.79). Risks of locoregional recurrence and contralateral breast cancer were not significantly different across age groups.

Conclusion.
Elderly patients with breast cancer were at increased risk for distant recurrence. Other studies have shown that the risk of distant recurrence is mainly affected by adjuvant systemic therapy. All TEAM patients received adjuvant endocrine treatment; however, chemotherapy was administered less often in elderly patients. These findings are suggestive for consideration of chemotherapy in relatively fit elderly breast cancer patients with hormone-sensitive disease.
Expertise Regarding Dental Management of Oral Cancer Patients Receiving Radiation Therapy Among Western Australian Dentists
Authors: Frydrych AM , Slack-Smith LM , Park JH , Smith AC 
Published: December 2012

Objectives:Dental care forms an important part of the multidisciplinary management of oral cancer patients. The aim of this study was to examine actual and self-perceived knowledge and clinical expertise regarding dental management of oral cancer patients receiving radiation therapy among Western Australian general dentists.Materials and Methods:An invitation to participate in a web-based questionnaire was emailed to 1095 dentists registered with the Australian Dental Association (ADA), WA branch. To assess dentists’ knowledge and expertise, actual and perceived knowledge was investigated. Information regarding type of practice, practice location, year of graduation and number of oral cancer patients treated in the preceding 12 months was also obtained.Results:One hundred and ninety one dentists responded to the survey. General dentists who took part in the study appeared to possess some knowledge regarding dental management of oral cancer patients treated with radiation therapy. The majority of responders however identified deficiencies in their knowledge and willingness to participate in continuing education programs.Conclusion:In view of the rising incidence of oral cancer in Western Australia, efforts should be made to provide more clinically relevant training to dentists in this area.
Effect of feeding a selected combination of galacto-oligosaccharides and a strain of Bifidobacterium pseudocatenulatum on the intestinal microbiota of cats
Authors: Biagi Giacomo , Cipollini Irene , Bonaldo Alessio , Grandi Monica , Pompei Anna , Stefanelli Claudio , Zaghini Giuliano 
Published: December 2012

Abstract
Objective—To evaluate the growth kinetics of a strain of Bifidobacterium pseudocatenulatum (BP) on 4 oligo- or polysaccharides and the effect of feeding a selected probiotic-prebiotic combination on intestinal microbiota in cats.
Animals—10 healthy adult cats.
Procedures—Growth kinetics of a strain of cat-origin BP (BP-B82) on fructo-oligosaccharides, galacto-oligosaccharides (GOS), lactitol, or pectins was determined, and the combination of GOS and BP-B82 was selected. Cats received supplemental once-daily feeding of 1% GOS–BP-B82 (1010 CFUs/d) for 15 days; fecal samples were collected for analysis the day before (day 0) and 1 and 10 days after the feeding period (day 16 and 25, respectively).
Results—Compared with the prefeeding value, mean fecal ammonia concentration was significantly lower on days 16 and 25 (288 and 281 μmol/g of fecal dry matter [fDM], respectively, vs 353 μmol/g of fDM); fecal acetic acid concentration was higher on day 16 (171 μmol/g of fDM vs 132 μmol/g of fDM). On day 16, fecal concentrations of lactic, n-valeric, and isovaleric acids (3.61, 1.52, and 3.55 μmol/g of fDM, respectively) were significantly lower than on days 0 (5.08, 18.4, and 6.48 μmol/g of fDM, respectively) and 25 (4.24, 17.3, and 6.17 μmol/g of fDM, respectively). A significant increase in fecal bifidobacteria content was observed on days 16 and 25 (7.98 and 7.52 log10 CFUs/g of fDM, respectively), compared with the prefeeding value (5.63 log10 CFUs/g of fDM).
Conclusions and Clinical Relevance—Results suggested that feeding 1% GOS–BP-B82 combination had some positive effects on the intestinal microbiota in cats
Le français sur objectif universitaire
Authors: Boukhannouche Lamia 
Published: December 2012

Un programme de formation « Français sur objectif spécifique » ou « français sur objectif universitaire » permet aux apprenants d’acquérir les compétences langagières, disciplinaires et méthodologiques nécessaires à la réussite de leurs études universitaires. Ce projet de formation les aide aussi à intégrer de façon optimale les différentes composantes de l’université. Son objectif vise à la fois un perfectionnement et un approfondissement des connaissances générales et spécifiques en langue française dans les disciplines universitaires de la composante que veut intégrer un étudiant.
CD70 Deficiency Impairs Effector CD8 T Cell Generation and Viral Clearance but Is Dispensable for the Recall Response to Lymphocytic Choriomeningitis Virus
Authors: Munitic Ivana , Kuka Mirela , Allam Atef , Scoville Jonathan P. , Ashwell Jonathan D. 
Published: December 2012

Abstract
CD27 interactions with its ligand, CD70, are thought to be necessary for optimal primary and memory adaptive immune responses to a variety of pathogens. Thus far, all studies addressing the function of the CD27–CD70 axis have been performed in mice lacking CD27, in those overexpressing CD70, or in those in which these molecules were blocked or mimicked by Abs or recombinant soluble CD70. Because these methods have in some cases led to divergent results, we generated CD70-deficient mice to directly assess its role in vivo. We find that lack of CD70-mediated stimulation during primary responses to lymphocytic choriomeningitis virus lowered the magnitude of CD8 Ag-specific T cell response, resulting in impaired viral clearance, without affecting CD4 T cell responses. Unexpectedly, CD70–CD27 costimulation was not needed for memory CD8 T cell generation or the ability to mount a recall response to lymphocytic choriomeningitis virus. Adoptive transfers of wild-type memory T cells into CD70−/− or wild-type hosts also showed no need for CD70-mediated stimulation during the course of the recall response. Moreover, CD70 expression by CD8 T cells could not rescue endogenous CD70−/− cells from defective expansion, arguing against a role for CD70-mediated T:T help in this model. Therefore, CD70 appears to be an important factor in the initiation of a robust and effective primary response but dispensable for CD8 T cell memory responses.
A Double-blind Cross-over Study evaluating the Efficacy of a Light-activated Toothbrush
Authors: Uswak Gerry , Lee Jinhwa , Li Jennife 
Published: December 2012

ABSTRACT

Aim
The aim of this study was to determine the efficacy of a new, light-activated toothbrush, (Soladey-J3X) incorporated with a TiO2 semiconductor and a solar panel (test) with a similar toothbrush but without the active semiconductor and solar panel (control).

Materials and methods
Forty-nine adults aged 19 to 34 years completed a double-blind, cross-over study with each participant using the test and control brush for a period of 3 weeks each. The mean differences between baseline plaque and gingivitis scores and, after the subjects used, the test and control brushes were analyzed by the paired t-test.

Results
The test and control brush demonstrated a reduction in overall plaque scores, but the difference between the two brushes was not statistically significant. The Soladey-J3X, however, showed a statistically significant difference in the overall mean reduction in gingivitis and on the buccal and interproximal surfaces compared to the control.

Conclusion
Both the test and the control toothbrushes induced a reduction in plaque scores after 3 weeks of use but the differences between the two type of brushes were not statistically significant. However, the test brush was more efficacious than the control in reducing overall gingival index scores and on the buccal and interproximal surfaces. Additional in vivo and longer term clinical trials are, however, warranted to fully investigate the mechanism and efficacy of TiO2 semiconductor toothbrushes on plaque biofilm and gingival inflammation.

How to cite this article
Uswak G, Hoover J, Lee J, Li J, Karunanayake C. A Double-blind Cross-over Study evaluating the Efficacy of a Light-activated Toothbrush. Int J Experiment Dent Sci 2012;1(2):57-60.
Association between Breastfeeding and Deleterious Oral Habits with Development of Malocclusions in Pediatric Dental Patients
Authors: Barreto Larissa Barreto , Souza Ricardo Alves , Freitas Livia Maria , Pithon Matheus Melo 
Published: December 2012

ABSTRACT

Purpose
This article evaluates the inter-relationship between the feeding time, presence of deleterious oral habits and the development of malocclusion.

Materials and methods
For this purpose, a document focused on the quantitative aspects and was prepared using forms filled out according to the information available in the medical records of 93 children of both genders, aged between 4 and 12 years old, who were treated at the Dental Clinic of UESB (University of the Southwest State of Bahia), Jequié Campus, in the period from 2006 to 2009. The Chi-square statistical test was applied.

Results
We observed a higher frequency of children who were naturally breast-fed for a period longer than 6 months (47%). There was a significant relationship between the shorter duration of breastfeeding leading to deleterious oral habits, and consequently to the development of malocclusion (p < 0.001). The existence of one or more deleterious oral habits also favored the development of malocclusion, even in the group that was breast-fed for longer than 6 months (p < 0.001). The habit that appeared most frequently was onychophagy (nail biting; 26%) followed by lingual interposition (17%) and pacifier sucking (14%). The highest prevalence of crowding was found among children with malocclusion (33%).

Conclusion
Mothers should be encouraged to extend the time of breastfeeding and motivate children not to develop deleterious oral habits, as these are crucial factors in diminishing the development of malocclusion.

How to cite this article
Barreto LB, Souza RA, Freitas LM, Pithon MM. Association between Breastfeeding and Deleterious Oral Habits with Development of Malocclusions in Pediatric Dental Patients. Int J Experiment Dent Sci 2012;1(2):61-66.
Does bonding to Dentin reduce Gap formation in Composite Restorations?
Authors: Popoff Daniela Araújo Veloso , Menezes Murilo de Sousa , Gomes Andressa dos Santos , Faria-e-Silva André Luis , Soares Paulo Vinícius , Santos-Filho Paulo César , Martins Luís Roberto Marcondes 
Published: December 2012

ABSTRACT
This study evaluated the effect of adhesive application only to enamel on the gap formation of composite resin restorations performed with different adhesive systems and submitted to mechanical cycling. Standardized cylinder-shaped cavities were prepared on the buccal surface of 60 bovine incisors. Two etchand-rinse [Adper Scotchbond Multi-purpose (3M ESPE, St. Paul, MN, USA) and Adper Single Bond 2 (3M ESPE)] and one selfetching [Clearfil SE Bond (Kuraray, Osaka, Japan)] adhesive systems were evaluated. The adhesives were applied only to enamel or to both dentin and enamel. After adhesive light activation, the cavities were restored with composite resin. The restorations were finished and polished; the marginal adaptation was analyzed using scanning electronic microscopy (SEM, 500× magnification) in low-vacuum mode. After the first evaluation, the samples were submitted to mechanical cycling (300,000 cycles of 80 kN and 1.5 Hz) and a new evaluation was performed. There was observed any gap for all experimental conditions before and after mechanical cycling. Bonding to dentin does not alter the marginal adaptation of composite restorations.

How to cite this article
Popoff DAV, Menezes MS, Gomes AS, Faria-e-Silva AL, Soares PV, Santos-Filho PC, Martins LRM. Does bonding to Dentin reduce Gap formation in Composite Restorations? Int J Experiment Dent Sci 2012;1(2):67-70.
Quality of Preclinical and Clinical Root Canal Fillings performed by Undergraduate Students on Single-rooted Teeth
Authors: Faria-e-Silva André Luis , Brito-Júnior Manoel , Camilo Carla Cristina , Veloso Daniela Araújo Veloso 
Published: December 2012

ABSTRACT
This study evaluated the radiographic technical quality of preclinical and clinical root canal fillings (RCF) performed by undergraduate students on single-rooted teeth. Two independent calibrated endodontic specialists evaluated 94 preclinical radiographs (group 1) and 96 clinical radiographs (group 2). The apical length of each RCF was categorized as acceptable (0-2.0 mm short of the radiographic apex), underfilled (2.0 mm or more short of the radiographic apex) and overfilled (extruded beyond the radiographic apex). Inadequate or adequate homogeneity were also evaluated based on the presence of voids and the uniform density of the RCF. Cohen's kappa and Chi-square tests (p < 0.05) were used for statistical analysis. The interexaminer agreement level was almost perfect (>0.80). Approximately 80% of RCF had acceptable length in both groups, with no significant differences among them (p > 0.05). The rate of adequate homogeneity was higher in Group 2 when compared with group 1 (p < 0.05). Overall, the quality of RCF was satisfactory with better homogeneous seal at the clinical level.

How to cite this article
Brito-Júnior M, Camilo CC, Popoff DAV, Saini R, Faria-e-Silva AL. Quality of Preclinical and Clinical Root Canal Fillings performed by Undergraduate Students on Singlerooted Teeth. Int J Experiment Dent Sci 2012;1(2):71-74.
Mercury Accumulation in Fish: The Potential Effect of Dental Amalgam Wastewater
Authors: Pinheiro Tiago Novaes , Consolaro Alberto , Sakuma Alice , Buzzo Marcia Liane , Carvalho Marcia Sena de , Duran Maria Cristina 
Published: December 2012

ABSTRACT

Objectives
Dental amalgam discharge in the wastewater stream is a potential source of mercury (Hg) that may contaminate the soil, water and wildlife, once released without safety measures. This study aimed the total Hg accumulation in fish Carassius auratus comparing different water environments: Water from the Tietê river basin close to the metropolitan area of Bauru, Brazil; tap water contaminated with 0.5 gm/l load of dental amalgam and tap water was used as control.

Study design
Fish were kept in glass aquaria, each water environment consisted of 25 specimens. The inner organs and muscles were sampled at 1 hour and 28 days for total Hg accumulation analysis. Also, water samples were analyzed at 1 hour, 7, 14, 21 and 28 days through cold vapor atomic absorption spectrometry.

Results
Only the fish kept at water from the Tietê river and contaminated tap water had Hg detected on its sampled tissues. The highest median levels were found in inner organs: 12.36 mg/kg–Tietê river and 262.64 mg/kg–contaminated tap water. The lowest median concentrations were found in muscles: 0.13 mg/kg–Tietê river and 0.54 mg/kg–contaminated tap water.

Conclusion
These findings alert to the potential environmental risks of dental amalgam waste discharge.

How to cite this article
Pinheiro TN, Consolaro A, Sakuma A, Buzzo ML, de Carvalho MS, Duran MC. Mercury Accumulation in Fish: The Potential Effect of Dental Amalgam Wastewater. Int J Experiment Dent Sci 2012;1(2):75-80.
Bond Strength of Resin Composites used as Core Materials around Different Types of Fiber Posts
Authors: Koçak Mustafa Murat , Cengiz Seda 
Published: December 2012

ABSTRACT
The purpose of this study was to evaluate the shear bond strength of two resin composites around different types of fiber posts. Twenty post specimens were prepared for three types of fiber posts. Posts were embedded in acrylic resin blocks with half of the post diameter exposed. The exposed portions of the posts were successively ground with silicon carbide paper until flattened flush with the acrylic resin, to create a standard smooth surface. All the posts were treated with a single silane coupling agent layer. After silane application, the posts were gently air dried. Three types of fiber posts were randomly divided into two groups, according to the resin composite used. The light-cured composite resins were placed in a polytetrafluoroethylene mold positioned over the post specimens and they were polymerized. Shear bond strength values (MPa) of posts and composite resin cores were measured using an universal test machine. Twoway analysis of variance (ANOVA) and Tukey's test were used for statistical analysis. The result of two-way ANOVA showed that the difference between the post groups was not significant (p = 0.59). But significant differences were observed between the core materials (p = 0.018). The shear bond strength values were not affected by the type of the fiber post. The type of the composite core material affected the bond strength values between the fiber post and composite core.

How to cite this article
Koçak MM, Cengiz S, Koçak S. Bond Strength of Resin Composites used as Core Materials around Different Types of Fiber Posts. Int J Experiment Dent Sci 2012; 1(2):81-83.
In vitro Comparison between Two Different Implant Titanium Surfaces in Osseointegration Process
Authors: Ballini Andrea , Desiate Apollonia , Cantore Stefania 
Published: December 2012

ABSTRACT
The osseointegration rate of titanium dental implants is related to their composition and surface roughness. Rough-surfaced implants favor both bone anchoring and biomechanical stability.
The future of dental implantology should aim to develop surfaces with controlled and standardized topography or chemistry.
This approach will be the only way to understand the interactions between proteins, cells and tissues and implant surfaces. The local release of bone stimulating or resorptive drugs in the peri-implant region may also respond to difficult clinical situations with poor bone quality and quantity, such as implant design and surface. These therapeutic strategies should ultimately enhance the osseointegration process of dental implants for their immediate loading and long-term success. Aim of this work was to compare implant titanium surfaces prepared with two different topographies for evaluating osteoblasts adhesion and growth.

How to cite this article
Ballini A, Desiate A, Cantore S. In vitro Comparison between Two Different Implant Titanium Surfaces in Osseointegration Process. Int J Experiment Dent Sci 2012; 1(2):84-88.
Study of Stress Distribution in Maxillary Anterior Region during True Intrusion of Maxillary Incisors using Finite Element Methodology
Authors: Vadvadgi Vinay , Bhardwaj Amit , Padmawar Sagar S , Belludi Anup 
Published: December 2012

ABSTRACT

Introduction
One of the major challenges of fixed clinical orthodontics is the correction of deep overbite. Miniscrew implants are ideally suited for absolute intrusion because they make it possible to apply light continuous forces of known magnitudes without producing any reciprocal reactionary effect on posterior teeth. The purpose of this finite element method (FEM) study was to evaluate and compare the stresses generated in maxillary anterior region during absolute en masse intrusion of six maxillary teeth using mini-implants at strategic locations.

Materials and methods
Finite element model was generated using FEM software and on the same model finite element analysis was carried out to study the stress distribution in maxillary anterior region during true incisor intrusion.

Results
Soft bone and hard bone showed significantly high stress distribution in maxillary anterior region.

Conclusion
Stresses on the teeth, soft bone and hard bone, were concentrated more on and near the central incisors as compared to lateral incisors. This was probably because the point of force application was between the central incisors and away from the lateral incisors.

How to cite this article
Padmawar SS, Belludi A, Bhardwaj A, Vadvadgi V, Saini R. Study of Stress Distribution in Maxillary Anterior Region during True Intrusion of Maxillary Incisors using Finite Element Methodology. Int J Experiment Dent Sci 2012;1(2):89-92.