bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of COVID-19 lockdowns on quality-of-life and health services access by socio-economic status in Australia
Authors: Feng Ying Ru , Li Ian , Kristoffersen Ingebjorg , Armstrong Bruce K , Preen David B 
Published: August 2024

Abstract
This study examined changes in physical and mental health quality-of-life and health services access before and after the onset of the COVID-19 pandemic among individuals of lower and higher socio-economic status (SES) in Australia. Difference-in-differences and logistic regression models were undertaken using data from the Household, Income and Labour Dynamics in Australia (HILDA) survey and government data on COVID-19 lockdowns between January 2020 and February 2021. Individuals from higher SES reported larger decreases in mental health quality-of-life scores than those from lower SES after the onset of the pandemic. Those from lower SES reported less disruption with any health services (24.2% vs 30.4%; OR = 0.68; p &lt; 0.001), specifically dental services (8.2% vs 15.4%; OR = 0.51; p &lt; 0.001) and allied health services (5.9% vs 8.5%; OR = 0.60; p &lt; 0.001), compared with those from higher SES. Additional days under lockdown were associated with reduced access to all health services (OR = 1.19). Furthermore, long-term health conditions (higher SES: OR = 1.54) and scores indicative of poorer physical (lower SES: OR = 1.17; higher SES: OR = 1.07) and mental health (lower SES: OR = 1.16; higher SES: OR = 1.12) were associated with increased health services disruption. While individuals from higher SES were more likely than those from lower SES to experience greater relative declines in mental health and increased disruption with health services access, individuals with a greater apparent need for health services, regardless of SES, may have faced inequalities in accessing these services during the COVID-19 pandemic.
Understanding user engagement in mobile health applications from a privacy management perspective
Authors: Zheng Han , Zhao Lin , Luo Chen , Fu Shaoxiong , Chen Xiaoyu , Liang Shaobo 
Published: August 2024

Abstract
Mobile health applications (mHealth apps) have surged in popularity for their role in promoting knowledge exchange and providing emotional support among health consumers. However, this enhanced social connectivity via these apps has led to an escalation in privacy breaches, potentially hindering user engagement. Drawing upon the communication privacy management theory, this study proposes a moderated mediation model to link social privacy concerns to user engagement in mHealth apps. An online survey involving 1149 mHealth app users was conducted in China to empirically validate the proposed model. Results indicated that social privacy concerns were negatively related to user engagement in mHealth apps, and perceived privacy of the app partially mediated this relationship. Moreover, perceived control positively moderated the indirect relationship between social privacy concerns and user engagement via perceived privacy. Specifically, the negative impact of social privacy concerns on perceived privacy was mitigated for users who reported higher levels of perceived control, indicating that when users feel more in control of their personal data, they are less affected by concerns over social privacy. Theoretically, this study has the potential to help scholars understand user engagement in mHealth apps from a privacy management perspective. Practically, the results of this study could assist mobile app providers and health professionals in devising evidence-based strategies to enhance social engagement and promote effective and sustainable use of mHealth apps among health consumers.
Identifying barriers and facilitators to physical activity and perceptions of Traditional Indigenous Games among Aboriginal and Torres Strait Islander women: a qualitative study
Authors: Thorne Tiana , Taylor Sean , Canuto Karla , Leicht Anthony S 
Published: August 2024

Abstract
Aboriginal and Torres Strait Islander women are key members of the community who have specific roles within their families that may result in lower levels of physical activity (PA) undertaken. Clearly identifying barriers for women to engage with PA, and exploring culturally based activities (i.e. Traditional Indigenous Games), may help to improve long-term health benefits. Subsequently, the aim of this study was to identify the barriers and facilitators for Aboriginal and Torres Strait Islander women engaging in PA, and their interest in participating in Traditional Indigenous Games. Seventeen Aboriginal and Torres Strait Islander women (34.3 ± 10.2 years) participated in focus groups. Through thematic analysis, participants experienced a range of common barriers such as lack of time due to family commitments, limited finances, ageing and poor physical and/or mental health. Common facilitators were also identified such as fun, access and improving mental and/or physical health. Importantly, unique themes were identified for Aboriginal and Torres Strait Islander women including barriers (e.g. racism, shame) and facilitators (e.g. culture, interactions with other Aboriginal and Torres Strait Islander women) that influenced PA participation. Notably, Traditional Indigenous Games were considered as an appealing PA mode to engage with their culture, experience nostalgia and be around other Aboriginal and Torres Strait Islander women. These key findings will guide future PA programs including Traditional Indigenous Games to improve health outcomes of Aboriginal and Torres Strait Islander women, vital members of the community.
‘One morning you would open the paper … and read, Return of Parnell’: rumours, legends and conspiracy narratives about Charles Stewart Parnell’s staged death
Authors: McConnel James 
Published: August 2024

Abstract
This article is the first to reconstruct the contemporary legend that Charles Stewart Parnell staged his own death in 1891, pending his messianic return. Although the British press folklorized it as a pre-modern Irish ‘peasant’ delusion, this article demonstrates that the story was one of several pseudocidal narratives about ‘great men’ shaped by the British ‘cult of Napoleon’. The legend did circulate in Ireland, but among city-dwelling Dubliners, not ‘peasants’. This article argues that for some urban Parnellites it functioned as a mode of political resistance; but for most Irish people, doubt and uncertainty, rather than wholehearted belief, characterized its reception.
Embryo multinucleation: detection, possible origins, and implications for treatment
Authors: Coticchio Giovanni , Lagalla Cristina , Taggi Marilena , Cimadomo Danilo , Rienzi Laura 
Published: August 2024

Abstract
Cell cycle regulation is crucial to assure expansion of a cell population, while preserving genome integrity. This notion is especially relevant to fertilization and early embryo development, a time when the cell cycle transforms from meiotic into mitotic cycles. Zygote-to-embryo transition is acutely error-prone, causing major developmental perturbations, including cleavage delays, tri- and multi-chotomous cleavages, and cell fragmentation. Another such alteration is bi- and multinucleation, consisting of the simultaneous formation of two or more nuclei at interphase. Indeed, multinucleation affects a large proportion of early human embryos, typically at the two-cell stage. Mechanistically, several factors, including spindle dysfunction, failed cleavage, and cell fusion, may generate this cell anomaly. In assisted reproduction treatment, multinucleation is associated with reduced developmental rates and lower implantation rates in Days 2–3 embryo transfers. However, many multinucleated embryos can develop to the blastocyst stage. In blastocyst transfers, the current evidence does not suggest a major impact of a previous history of multinucleation on the odds of euploidy or successful treatment outcomes. Human embryo multinucleation remains a not-fully-understood but developmentally relevant and intriguing phenomenon which requires further research of its generative mechanisms and clinical implications.
Three decades of international cooperation against corruption—looking ahead
Authors: Borlini Leonardo , Peters Anne 
Published: August 2024

Abstract
Corruption, a ubiquitous phenomenon throughout history and societies, has been long criminalized in many countries. However, international cooperation against corruption only gained momentum in the 1990s. Since then, the international legal framework has expanded significantly through conventions like the Organisation on Economic Co-operation and Development (OECD) Anti-Bribery Convention and the UN Convention against Corruption. Nearly all states have now ratified at least one anticorruption treaty. However, implementation and enforcement of these standards has been uneven across states. Domestic reforms have also lagged in some areas like prevention. Corruption remains widespread, and its socioeconomic costs have not appreciably decreased. This Symposium aims at assessing the outcomes of three decades of international cooperation in combating corruption, while also exploring the future directions of international anticorruption rules and cooperation. Through a positive, critical, and normative legal analysis, complemented by empirical research and behavioral science, it focuses on the dynamic interactions between international anticorruption instruments and municipal law, highlighting understudied problems, both substantive and methodological. After discussing the origins and evolution of international anticorruption law, this introductory article presents the state of the art on the questions tackled by this Symposium and highlights its contribution to existing literature on the topic. In doing so, it brings together various trends emerging from the articles contained in this Symposium and explores avenues for further research and reflection.
Monitoring and compliance mechanisms as a diagnostic and prognostic tool of international anti-corruption cooperation: A data-driven study
Authors: Borlini Leonardo 
Published: August 2024

Abstract
This article focuses on text-as-data analysis to identify and compare the main patterns in the implementation of international anti-corruption rules, as well as compliance with them. It is based on the observation that a comprehensive study of the operation and outcomes of international anti-corruption treaties’ monitoring and compliance mechanisms (MMs) has not yet been attempted. The primary objectives are twofold: first, to obtain structured information in the form of data on compliance with the main anti-corruption treaties by processing the text of the reports these MMs have published since their creation; and, second, to examine the impact of these treaties on state behaviour by elaborating on this newly structured information (i.e., text-as-data). This article offers the first comprehensive review of country performance, combined with a structured legal analysis of outcomes from the perspective of the interaction between international and domestic law. The findings reveal that results in implementation and compliance have been decidedly mixed. Several countries have introduced reforms to implement anti-corruption treaties, facilitate law enforcement, and ease international cooperation to investigate and prosecute corruption offences. However, numerous problems identified with prevention, particularly in European and American countries, suggest that states too often over-rely on the repressive aspects of fighting corruption and undervalue preventive mechanisms, which frequently do not exist or are inadequate. Moreover, the article identifies enduring challenges and signs of regression across different areas of prevention, criminal repression, and international cooperation, which have far-reaching implications for the effectiveness of anti-corruption policies in many jurisdictions. Finally, the data obtained from the Organisation for Economic Co-operation and Development demonstrates considerable disparities in enforcement among the reviewed countries; a few jurisdictions have yet to see a single foreign bribery case prosecuted. Additionallly, they offer new evidence that reasons for poor compliance are highly contextual, with different implications for domestic reforms.
Corruption and foreign investments: Empirical lessons from treaties and arbitration cases
Authors: Kryvoi Yarik 
Published: August 2024

Abstract
As legally binding instruments for the protection of cross-border investments, international investment agreements (IIAs) increasingly include anti-corruption provisions. This article empirically analyzes international investment agreements and the practice of investor–state tribunals related to corruption in foreign investments. It introduces a typology of treaty provisions and discusses their limited practical effectiveness and perverse incentives they create. The article also addresses the broader question of how to deal with corruption-related obligations of investors and states in the context of public international law. It presents and analyzes new empirical data showing that parties to investor–state disputes increasingly allege corruption, and states are responsible for most of such allegations. However, in most cases, tribunals either ignore such allegations or decide that they have not been proven. In the small number of cases where tribunals found allegations proven, they declined jurisdiction or declared the investor’s claim inadmissible. The article makes proposals on how international investment law can become more effective in tackling the supply and demand side of corruption and discusses the relevant obligations of investment tribunals.
Robustness of copula-correction models in causal analysis: Exploiting between-regressor correlation
Authors: Haschka Rouven E 
Published: August 2024

Abstract
Accepted by: Phil Scarf
Causal analysis in management and marketing often faces the challenge of endogeneity, which can result in biased estimates when methods that assume independence between regressors and errors are applied. The joint copula modeling approach proposed by Park and Gupta (Marketing Science, 2012, 31(4), 567–586) provides a practical solution to this issue by modeling the joint distribution of endogenous regressors and errors. This paper proposes a generalisation of their approach with an endogeneity correction that involves the exogenous variables. We first show that the estimator by Park and Gupta requires the strong assumption of independence between the endogenous and the exogenous regressors, and suffers from an omitted variables bias when this assumption is violated. We also quantify this bias. The distinguishing characteristic of the proposed approach is that we use a first-stage auxiliary regression to generate copula correction functions by exploiting the informational content of the exogenous variables in a similar spirit as instrumental-based identification. As this first-stage regression does not generate an additional identification problem, is not more restrictive than the Park and Gupta model. The approach is least-squares-based and thus neither requires numerical optimisation nor the search for starting values. Monte Carlo simulations reveal that the proposed approach performs well in finite samples. We demonstrate the practical applicability by reassessing the empirical example in Park and Gupta using the proposed approach.
Mixed finite elements for the Gross–Pitaevskii eigenvalue problem: a priori error analysis and guaranteed lower energy bound
Authors: Gallistl Dietmar , Hauck Moritz , Liang Yizhou , Peterseim Daniel 
Published: August 2024

Abstract
We establish an a priori error analysis for the lowest-order Raviart–Thomas finite element discretization of the nonlinear Gross-Pitaevskii eigenvalue problem. Optimal convergence rates are obtained for the primal and dual variables as well as for the eigenvalue and energy approximations. In contrast to conforming approaches, which naturally imply upper energy bounds, the proposed mixed discretization provides a guaranteed and asymptotically exact lower bound for the ground state energy. The theoretical results are illustrated by a series of numerical experiments.
Gompf’s Cork and Heegaard Floer Homology
Authors: Dai Irving , Mallick Abhishek , Zemke Ian 
Published: August 2024

Abstract
Gompf showed that for $K$ in a certain family of double-twist knots, the swallow-follow operation makes $1/n$-surgery on $K \# -K$ into a cork boundary. We derive a general Floer-theoretic condition on $K$ under which this is the case. Our formalism allows us to produce many further examples of corks, partially answering a question of Gompf. Unlike Gompf’s method, our proof does not rely on any closed 4-manifold invariants or effective embeddings, and also generalizes to other diffeomorphisms.
Disease-Specific Differences in Pharmacokinetics of Paromomycin and Miltefosine Between Post-Kala-Azar Dermal Leishmaniasis and Visceral Leishmaniasis Patients in Eastern Africa
Authors: Chu Wan-Yu , Verrest Luka , Younis Brima M , Musa Ahmed M , Mbui Jane , Mohammed Rezika , Olobo Joseph , Ritmeijer Koert , Monnerat Séverine , Wasunna Monique , Roseboom Ignace C , Solomos Alexandra , Huitema Alwin D R , Alves Fabiana , Dorlo Thomas P C 
Published: August 2024

Abstract
Treatment regimens for post-kala-azar dermal leishmaniasis (PKDL) are usually extrapolated from those for visceral leishmaniasis (VL), but drug pharmacokinetics (PK) can differ due to disease-specific variations in absorption, distribution, and elimination. This study characterized PK differences in paromomycin and miltefosine between 109 PKDL and 264 VL patients from Eastern Africa. VL patients showed 0.55-fold (95% confidence interval [CI], .41–.74) lower capacity for paromomycin saturable reabsorption in renal tubules, and required a 1.44-fold (95% CI, 1.23–1.71) adjustment when relating renal clearance to creatinine-based estimated glomerular filtration rate. Miltefosine bioavailability in VL patients was lowered by 69% (95% CI, 62%–76%) at treatment start. Comparing PKDL to VL patients on the same regimen, paromomycin plasma exposures were 0.74- to 0.87-fold, while miltefosine exposure until the end of treatment day was 1.4-fold. These pronounced PK differences between PKDL and VL patients in Eastern Africa highlight the challenges of directly extrapolating dosing regimens from one leishmaniasis presentation to another.
Microbiome and Metabolome Restoration After Administration of Fecal Microbiota, Live-jslm (REBYOTA) for Preventing Recurrent Clostridioides difficile Infection
Authors: Blount Ken F , Papazyan Romeo , Ferdyan Nicky , Srinivasan Karthik , Gonzalez Carlos , Shannon William D , Fuchs Bryan C 
Published: August 2024

Abstract

Background
Microbiota-based treatments are effective in preventing recurrent Clostridioides difficile infection. Fecal microbiota, live-jslm (REBYOTA; RBL, previously RBX2660) was shown to prevent recurrent C difficile infection in a phase 3 clinical trial (PUNCH CD3) based on a randomized, double-blinded, placebo-controlled design.

Methods
Stool samples from participants in PUNCH CD3 who received a single blinded dose of rectally administered RBL or placebo were sequenced to determine microbial community composition and calculate the Microbiome Health Index for postantibiotic dysbiosis. The composition of bile acids (BAs) in the same samples was quantified by liquid chromatography–mass spectrometry. Relationships between BA composition and microbiota community structure and correlations with treatment outcomes were assessed.

Results
Before administration, Gammaproteobacteria and Bacilli dominated the microbiota community, and primary BAs were more prevalent than secondary BAs. Clinical success after administration correlated with shifts to predominantly Bacteroidia and Clostridia, a significant increase in Microbiome Health Index for postantibiotic dysbiosis, and a shift from primary to secondary BAs. Several microbiota and BA changes were more extensive in RBL-treated responders as compared with placebo-treated responders, and microbiota changes correlated with BA changes.

Conclusions
Clinical response and RBL administration were associated with significant restoration of microbiota and BA composition.

Clinical Trials Registration
NCT03244644 (https://clinicaltrials.gov/ct2/show/NCT03244644).
The Physiological and Biochemical Response of Ribbed Mussels to Rising Temperatures: Benefits of Salt Marsh Cordgrass
Authors: Smith A , Erber J , Watson A , Johnson C , Gato W E , George S B 
Published: August 2024

Synopsis
Salt marsh ecosystems are heavily reliant on ribbed mussel (Geukensia demissa) populations to aid in rapid recovery from droughts. The focus of this study was thus to document the effects of rising temperatures on ribbed mussel populations in a Georgia salt marsh. Seven lab and eight field experiments were used to assess the effects of current air temperatures on mussels at two high marsh (HM) sites with short and sparse cordgrass and one mid marsh (MM) site with tall and dense cordgrass. Field results in 2018 and 2019 indicate that ribbed mussels were experiencing extremely high temperatures for prolonged periods of time at the landlocked high marsh (LHM) site. In 2018, the highest temperature (54°C) and longest high temperature events, HTEs (58 days), that is, consecutive days with temperatures ≥40°C, were recorded at this site. When laboratory temperatures were increased from 20 to 36°C, mean heart rates increased by an average of 19 bpm for mussels from both high and MM sites respectively. When field temperatures rose from 20°C in April to 40°C in September 2019, mean heart rates increased by an average of 10 bpm for HM mussels and by 26.3 bpm for MM mussels. Under identical laboratory and field conditions, mean heart rates for mussels from the LHM site with the highest temperatures, increased by &lt;1 bpm and 3.7 bpm respectively. Evidence of the potential role of shade on mussel aggregates was provided by examining whether mussels from the edge of mussel aggregates with little to no cordgrass for shade were more stressed than those living at the center of mussel aggregates. In the absence of shade, mean body temperatures for mussels at the edge of mussel aggregates were up to 8°C higher than for those living in the center underneath a dense tuft of cordgrass. Despite high body temperatures, mean heart rates and Hsp70 gene expression were lower for mussels living at the edges. This agrees with the strategy that during prolong exposure to high temperatures, mussels may reduce their heart rate to conserve energy and enhance survival. Alternatively, heat-stressed mussels at the edges of aggregates may not have the resources to express high levels of Hsp70. Increase in the frequency, intensity, and duration of HTEs may stress the physiological and biochemical function of mussel populations to the limit, dictate mussel aggregate size, and threaten the functionality of SE salt marshes.