bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paeonol attenuated high glucose-induced apoptosis via up-regulating miR-223-3p in mouse cardiac microvascular endothelial cells
Authors: Deng Bo , Xian Ruyu , Shu Yuan , Xia Haohan , Feng Chengcheng 
Published: July 2024

AbstractTo investigate the role of miR-223-3p in the modulatory effect of paeonol (Pae) on high glucose (HG)-induced endothelial cell apoptosis. HG (25 mmol/L) was used to induce cellular damage and apoptosis in the mouse cardiac microvascular endothelial cells (MCMECs). Various concentration of Pae was tested and 60 μmol/L Pae was selected for the subsequent studies. MCMECs were transfected with exogenous miR-223-3p mimics or anti-miR-223-3p inhibitors. Cell viability was assessed by MTT assay and apoptosis was quantified by flow cytometry. The expression of miR-223-3p and NLRP3 mRNA was measured using real-time quantitative RT-PCR, and protein level of NLRP3 and apoptosis-related proteins was detected by immunoblotting. Pae significantly attenuated HG-induced apoptosis of MCMECs in a concentration-dependent manner. In addition, Pae (60 µmol/L) significantly reversed HG-induced down-regulation of miR-223-3p and up-regulation of NLRP3. Pae (60 µmol/L) also significantly blocked HG-induced up-regulation of Bax and Caspase-3 as well as down-regulation of Bcl-2. Moreover, exogenous miR-223-3p mimics not only significantly attenuated HG-induced apoptosis, but also significantly suppressed NRLP-3 and pro-apoptotic proteins in the MCMECs. In contrast, transfection of exogenous miR-223-3p inhibitors into the MCMECs resulted in not only significantly increased apoptosis of the cells, but also significant suppression of NLRP3 and pro-apoptotic proteins in the cells. Pae attenuated HG-induced apoptosis of MCMECs in a concentration-dependent manner. MiR-223-3p may mediate the modulatory effects of Pae on MCMEC survival or apoptosis through targeting NLRP3 and regulating apoptosis-associated proteins.
Writing to evaluate
Authors: Xuan Winfred Wenhui , Chen Shukun 
Published: July 2024

Abstract
Evaluative language is crucial in English for Academic Purposes (EAP) writing, particularly in expressing
authorial stance and supporting arguments. Among various linguistic frameworks, appraisal in Systemic Functional Linguistics (SFL)
has been extensively used to map and assess evaluative linguistic features. Since its inception in the early 1990s, appraisal has
been widely applied to EAP writing studies. This synthesis reviews EAP writing studies using the appraisal framework published
over the past decades, synthesizing 69 publications. We developed coding schemes based on research questions, focusing on learner
levels, subjects studied, text type, and generated findings. Our findings indicate that appraisal has been applied by EAP writers
at different levels to perform a range of functions in their writing. However, previous studies show that there is a lack of
longitudinal study of appraisal resources used by EAP writers at different levels. We recommend systematic and explicit
instruction in the use of appraisal resources in EAP writing. Based on our findings, we offer pedagogical
suggestions for EAP writing and teaching, aiming to enhance the effectiveness of EAP instruction and the quality of student
writing.
Structures in discourse
Authors: Wårvik Brita 
Published: July 2024

Abstract
Texts are expected to have structure and the study of
that structure is a central concern in text and discourse linguistics. Texts
are semantic units and their structure is therefore a matter of organization
of the content material included in them. At the same time, text structure
is also a matter of form, since texts manifest linguistic signals of various
kinds whose purpose is to facilitate the text receiver’s task of
interpretation, i.e. the task of building a text world around a given text.
And even shape can be used to disclose the structure of a given text. (Virtanen 1997a)
WITHDRAWN: Photonics of Two-Dimensional Structures Formed by Cholesteric Liquid Crystals
Authors: Dolganov P. V. , Baklanova K. D. , Dolganov V. K. 
Published: July 2024

Notice of Withdrawal
This paper was withdrawn by IOP Publishing on 30/08/2024. This paper was published due to an error. The authors are free to publish this work elsewhere. IOP Publishing apologise for this error.
Digital pedagogy: experiential learning theory improves mathematics learners’ engagement and learning outcomes in optical physics course
Authors: Lima Amanda de Barros , Sorroche Julia , Tagiku Armando Massao , Neto Jose Dutra de Oliveira 
Published: July 2024

Abstract
In response to the evolving educational landscape during the COVID-19 pandemic, this study explores the application of experiential learning theory (ELT) in an Optical Physics course for mathematics undergraduates. With a focus on improving engagement and academic performance, we address the critical need for effective pedagogical approaches in a virtual environment. The study involves 176 students, encompassing a wide demographic spectrum, during 2021, and utilises an extensive theoretical framework to support the ELT approach. The core of the study is an innovative learning model based on hands-on experiments, designed to enhance engagement, deepen understanding, and promote active learning. Students perform a series of experiments, reflect on their observations, connect theory to practice, and answer challenging questions that link theoretical concepts with real-world applications. Our results reveal a significant improvement in students’ academic outcomes, with higher average grades and reduced course abandonment compared to the previous year. The study also explores students’ perceptions, revealing their appreciation for this active learning approach, as it enhances motivation, concentration, enjoyment, and perceived learning. Collecting data through questionnaires, in-class feedback, andpost-class email reflections further validates the effectiveness of the Kolb-based ELT approach. In conclusion, our study demonstrates the power of implementing hands-on experiential learning in virtual education settings, fostering deeper engagement and improved academic outcomes, especially in a post-pandemic world where such pedagogical innovation is vital.
SiPM and readout electronics for the JUNO-TAO Central Detector
Authors: Venettacci C. ,   the JUNO collaboration
Published: July 2024

Abstract
The Taishan Antineutrino Observatory (TAO) is a satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). TAO consists of a spherical ton-level Gadolinium-doped Liquid Scintillator detector and its main purpose is the precise measurement of the reactor antineutrino spectrum by detection of light produced in v̅e
+ p⟶ e
+ + n reaction, as a reference for JUNO. About 4,500 photoelectrons per MeV could be detected by instrumenting the sphere surface (∼10 m2) with state-of-the-art Silicon PhotoMultipliers (SiPMs), resulting in a sub-percent energy resolution. In this work we present the implemented architecture of the readout electronics based on low-noise, high-speed Front-End Boards (FEBs) connected to a 50×50 mm2 SiPM Hamamatsu tile, composed by 32 SiPM elements of 12×6 mm2 each, divided into two independent output channels. The overall 4,024 FEBs will be supplied through eight custom flanges that have to bring in about 1.5 kW. On the same flanges the 8,048 output signal cables are distributed and routed to the Front-End Controllers (FECs), based on Virtex Ultrascale FPGAs, able to manage up to eight 16-channel ADCs, for a total of 128 channels on a single FEC, with a maximum sampling rate of 250 MHz with 12-bit resolution. A dedicated trigger and data-acquisition system will filter and record occurring events, rejecting dark count events. We report the results of the characterization for the pre-production FEBs batch, following the main figures of merit defined for the experiment, showing single photoelectron resolution better than 13% and dynamic range up to 250 photoelectrons.
A novel method to simulate radon exhalation rate with a solid Rn-222 source
Authors: Li Huiying , Fan Zhongkai , Liu Shuaibin , Lin Fen , Hu Tao , Mo Yixiang , Yuan Shuai , Xie Ruomei , Sun Jiale , Yi Haibo , Liu Zhipeng , Wu Jiulin , Yuan Hongzhi , Tan Yanliang 
Published: July 2024

Abstract
Radon exhaled from rocks, building materials, and soil can
be harmful to human health, so it is necessary to measure radon and
its exhalation rate. In this paper, a novel method is proposed to
simulate radon exhalation from different medium surface by using a
solid Rn-222 source, and the radon exhalation rate can be adjusted
by replacing radon accumulation chambers with different bottom
areas. Firstly, an experiment was done to determine the activity of
the Rn-222 source, and then the theoretical radon exhalation rate
can be quickly calculated from the relationship between the radon
source activity and the bottom area of the radon accumulation
chamber. Three sets of comparative experiments were conducted using
two radon accumulation chambers with different volumes,
respectively. Comparing the average values obtained from the
experiments with the calculated theoretical values, it can be
obtained that the differences corresponding to the two radon
accumulation chambers between the theoretical radon exhalation rates
and the experimentally average values are all within 6%. Without
replacing the radon source, the radon exhalation rate is inversely
varies with the bottom area of the chamber. Therefore, the
correctness of adjusting the radon exhalation rate by replacing
radon accumulation chambers with different bottom areas to simulate
radon exhalation from different media surfaces is verified. This
method can be used to calibrate the radon exhalation measuring
instruments.
Image reconstruction from speckle patterns on double diffusers condition by deep learning
Authors: Chai Shouyu , Wang Jialong , Lu Mengyang , Gu Wenting , Li Boyi , Liu Xin 
Published: July 2024

Abstract
Reconstructing images from speckle patterns using deep learning methods is emerging as an effective alternative to traditional approaches. To overcome the potential multiple diffuser distortions occurring between the emission and the detection of the optical path, we establish a 4-f imaging system incorporating dual diffusers, one positioned in front of the image plane and the other after the object plane, to capture plenty of scattered object images. To effectively reconstruct from the experimentally acquired speckle patterns, we add the Triple Attention Module into the UNeXt convolutional network (TAM-UNeXt) and concurrently preprocess the autocorrelation spectrum of the patterns inspired by the angular memory effect theory. We compare the recovery results of the TAM-UNeXt under various conditions, including different grit sizes, numbers, and positions of the diffusers, as well as several optical lens setups, to verify its adaptability under diverse double diffuser conditions.
Essays on Perceptual Experience
Authors: Snowdon Paul F 
Published: July 2024

Abstract
A central figure in Anglo-American philosophy for over four decades, Paul Snowdon made seminal contributions to the fields of metaphysics, philosophy of mind, and the history of twentieth-century philosophy. Snowdon’s work on perception and perceptual experience—much of which is collected in this volume for the first time—was particularly impactful and firmly established “disjunctivism” as a view with which any theorist working in the field must reckon. In Part 1 (“Issues”), Snowdon traces the contours of the concept of perception, refining his formulation of the disjunctivist position, determining the degree of involvement of the concept of causation, and engaging critically with arguments which aim to support sense-data theories. In its critical examination of the views propounded by a number of influential philosophers, Part 2 (“Philosophers”) amounts to a partial sketch of the history of twentieth-century philosophy of perception. Among the figures whose work Snowdon engages are J. L. Austin, A. J. Ayer, Michael Ayers, Michael Hinton, John McDowell, G. E. Moore, H. H. Price, Wilfrid Sellars, P. F. Strawson, and Ludwig Wittgenstein. The volume opens with a robust and generous introduction in which Snowdon describes the theoretical challenges, approaches, and themes that animate the set of interrelated problems addressed across all sixteen chapters. Sprinkled throughout are an array of candid reflections that serve both to illuminate substantive connections between the chapters as well as the historical and circumstantial contexts that occasioned their writing.
Some Reflections on an Argument from Hallucination
Authors: Snowdon Paul F 
Published: July 2024

Abstract
The aim of the present chapter is to evaluate the strongest possible formulation of the argument from hallucination. To this end, the traditional argument is presented, refined, and strengthened, culminating in a formulation of the argument recently advanced by Howard Robinson. Following additional refinements and bolstering, various attempts to block Robinson’s argument are found either to be unsuccessful (in the case of Matthew Soteriou’s response) or ill-advised (in the case of resistance flowing from a commitment to dualism). In the final two sections, a new response is explored which begins by revealing the argument’s commitment to a conception of perceptual experience as the immediate effect of an inner neural cause. It is then demonstrated how the argument can be neutralized by understanding perceptual experience as consisting of a temporally extended physical process back to, and so including, the external object.
On the What-It-Is-Like-ness of Experience
Authors: Snowdon Paul F 
Published: July 2024

Abstract
It is common for philosophers to hold that experiences can be characterized in terms of their possessing something best capturable in such words as ‘being like something to undergo’. It is argued here that when this slogan is examined it is in some respects trivial (because experiences must be some way, and being events must be some way for the subject of them) and in others mistaken (because there can be non-experiences which can be like something for a thing to undergo). Thus, it is recommended that philosophers stop repeating the slogan.
G. E. Moore on Sense-Data and Perception
Authors: Snowdon Paul F 
Published: July 2024

Abstract
In his acute study of G. E. Moore, G. E. Moore: A Critical Exposition, A. R. White writes: “There are three main topics dealt with in Moore’s writings, namely, philosophical method, ethics, and perception.” As a general description, the only reservation that can be felt about this remark is that it would be more accurate to add epistemology as a fourth main topic. Moore obviously grappled in a variety of ways with the problems raised by scepticism. Now, it might be that White included epistemology under the title of ‘perception’, and it is, indeed, not uncommon to think of the name ‘philosophy of perception’ as covering epistemology. But another—and, I think, more likely—possibility is that White underestimated Moore’s epistemological concerns, perhaps because when White was writing a number of Moore’s essays on the subject were not widely known (or, at least, not known to White).
Austin on the Philosophy of Perception
Authors: Snowdon Paul F 
Published: July 2024

Abstract
One way to respond, today, to the work of Austin is to take an idea he had and to build on it, or, perhaps, to take an idea that Austin generated in others and to build on that, or, perhaps, to criticize ideas with these Austinian origins. But I suspect that readers of the volume in which this chapter first appeared (Garvey 2014) also share an interest in achieving what one might call an understanding and assessment of Austin himself as a philosopher. Putting it in a rather blunt way, we can ask: what major contributions did Austin make to philosophy? I shall of course only look at one area, as indicated in my title. The tone of this paper will be historical, general, loose, and to some extent speculative. But I hope to assemble some evidence that might influence how one sees his work, and through that, Austin himself.
Wittgenstein and the Possibility of Meaning
Authors: Miller Alexander 
Published: July 2024

Abstract
Inspired by Ludwig Wittgenstein’s later philosophy, this book develops a new, non-reductionist, response to the sceptical argument about meaning famously developed in Saul Kripke’s book Wittgenstein on Rules and Private Language. It begins by outlining an intuitive notion of following a rule, explaining its relationship to the notions of linguistic meaning and intentional content. It then gives an outline and development of Kripke’s Wittgenstein’s sceptical argument, going into detail on the arguments against reductive dispositional accounts of meaning. It also explains Kripke’s Wittgenstein’s objections to non-reductionist views which take semantic and intentional facts to be primitive and sui generis and argues against views – such as error theories and forms of non-factualism – which attempt to respond to the argument by conceding that there are no meaning facts. The position advocated in the book emerges from a response to recent arguments developed by Paul Boghossian (“The Inference Problem”) and Crispin Wright (“The Minor Premise Problem”) which appear to imply that rule-following and competent language use are impossible even if we assume that Kripke’s challenge has been met. A reply to Boghossian and Wright is then developed via a new account of Wittgenstein’s remarks on the notion of “following a rule blindly” or “blind rule-following” that connects it to the Wittgensteinian idea that there is a way of following a rule that does not involve interpretation. In turn, this is used to generate a response to Kripke: understanding an expression is a matter of having an intention to exercise one’s ability to use it in accord with its meaning or correctness condition.
Boghossian and Wright on Blind Rule-Following
Authors: Miller Alexander 
Published: July 2024

Abstract
This chapter outlines arguments by Paul Boghossian (the “Inference Problem”) and Crispin Wright (the “Minor Premise Problem”). According to these arguments, even if we have a plausible non-reductionist response to Kripke’s Wittgenstein’s sceptical challenge to the satisfaction of the (Acceptance) condition in the ACER model of rule-following, there are additional problems concerning the (Explanation) and (Rationalization) conditions. These additional problems threaten the idea that rule-following, or linguistic competence, are possible. The chapter also explains some of the ideas necessary for an understanding of the problems, in particular the nature of Wittgenstein’s attack on the Augustinian picture of the relationship between thought and language.
Verse and Conversion
Authors: Ungvary David 
Published: July 2024

Abstract
This chapter explores a question central to the development of Christian Latin poetry: Was there a way for classically trained authors to accommodate pagan literary traditions within a rigorous Christian life? Inquiry begins with the case of a young poet and member of Augustine’s retinue named Licentius, who, in Augustine’s De ordine, is prompted to consider whether there is room for verse writing within Christian life. Licentius’s subsequent conversion illustrates the ethical negotiations that Roman authors faced in balancing classical literary interests against the demands of an increasingly ascetic Christianity. This chapter argues that, to better appreciate Licentius’s dilemma, students of Late Latin verse must nuance their understandings of the literary dynamics of conversion, Christianization, asceticism, and religious identification. Subsections demonstrate the book’s interest in and methods for capturing particularly integrative forms of asceticism, which fostered the co-existence of classical and Christian attitudes and practices. Poetic expressions of asceticism are explored through the writings of Paulinus of Nola, dispatched by Augustine to teach Licentius about the possibilities of Christian poetry. Paulinus’s poetic tactics provided ambivalent Christians like Licentius with a model for converting poetry to Christian spiritual use.
Verse and Incursion
Authors: Ungvary David 
Published: July 2024

Abstract
This chapter examines how Gallo-Roman Christian poetry became a discourse of religious reform in the aftermath of civil war and barbarian invasion. Amid these crises, regional Christian poets composed poems to reflect on the spiritual consequences of political destabilization, and to direct compatriots to reorder their worlds according to Christian systems of value and ethics. At the center of the chapter is a close reading of the first of these poems of reform, the Epigramma Paulini, which responds to the barbarian breach of the Rhine in 406/7 with a diagnosis of Gaul’s moral and religious condition. Interpretation of the poem connects its allegorical, metapoetic, and genre-bending features to the conflicts of identity and ideology that aristocratic readers faced under the pressures of Christianization and barbarian invasion. The chapter concludes by examining evidence for conversation between Gallo-Roman ascetic authors and outside religious experts like Jerome, who asserted themselves as authoritative spiritual interpreters of Gaul’s political crises. Analysis suggests that interventions like Jerome’s propelled Gallo-Roman writers to develop their own idioms of spiritual reform to help reclaim a sense of religious self-determination.
Epilogue
Authors: Ungvary David 
Published: July 2024

Abstract
This chapter points to texts and contexts beyond Gaul where scholars may extend future explorations of the interplay between classicizing Latin poetry and Christian asceticism. Discussion centers on Ennodius of Pavia’s Eucharisticon, a confessional prose text written by a renunciant poet-cleric in Ostrogothic Italy. Interpretation seeks to explain the peculiarities of Ennodius’s self-presentation and pointed disavowal of poetry in light of the study’s previous readings. Allusive reverence toward Augustine’s Confessions, social and familial connections to authors like Sidonius and Avitus, and ascetically informed language within Ennodius’s text all reveal intellectual and literary affinities with Gallo-Roman Christian poetry developed through the fifth century. The study concludes by suggesting ways of deepening critical appreciation of the transmission and evolution of ascetic theories and practices of poetry into the early medieval period. It thus invites and equips readers to revisit the force of Christian Latin poetics in shaping the strategies and practices of conversion, authorship, and Christianization that gave form to the emergent cultures of the post-Roman West.