bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value of a Simplified Anatomically Based Nomenclature for Fetal Nuchal Lymphatic Anomalies
Authors: Longstreet Beck , Balakrishnan Karthik , Saltzman Babette , Perkins Jonathan A. , Dighe Manjiri 
Published: November 2014

ObjectiveTo propose an anatomic classification for fetal nuchal lymphatic anomalies that will be clinically useful and to evaluate the classification’s value in predicting chromosomal abnormalities, pregnancy outcomes, other associated fetal anomalies, and spontaneous resolution of these lesions.Study DesignRetrospective cohort study.SettingTertiary academic hospital and affiliated tertiary children’s hospital.Subjects and MethodsMother‐baby pairs diagnosed with fetal nuchal lymphatic anomalies in a prenatal ultrasound database. Anomalies were classified as nuchal thickening, dorsal lymphatic malformation, or ventral lymphatic malformation. Pregnancy outcomes, prevalence of chromosomal and anatomic abnormalities, and rates of spontaneous lesion resolution were determined for each group.ResultsThe study included 189 patients: 58 with nuchal thickening, 120 with dorsal lymphatic malformation, and 11 with ventral lymphatic malformation. In fetuses for whom chromosomal analysis was available, chromosomal abnormalities were strongly associated with dorsal lymphatic malformations (83%), less associated with nuchal thickening (29%), and not associated with ventral lymphatic malformations. Dorsal lymphatic malformation predicted high rates of elective (43%) and spontaneous (20%) termination of pregnancy and showed the strongest association with cardiac, renal, and skeletal anomalies. Nuchal thickening was more likely to resolve in utero than dorsal lymphatic malformations, while no ventral lymphatic malformation resolved spontaneously.ConclusionsFetal nuchal anomalies demonstrate significant and clinically important prognostic differences depending on their anatomic location. The simple classification system proposed here therefore provides useful information to clinicians involved in the pre‐ and postnatal management of children with these anomalies.
Intersections Between the Autism Spectrum and the Internet: Perceived Benefits and Preferred Functions of Computer-Mediated Communication
Authors: Gillespie-Lynch Kristen , Kapp Steven K. , Shane-Simpson Christina , Smith David Shane , Hutman Ted 
Published: November 2014

Abstract
An online survey compared the perceived benefits and preferred functions of computer-mediated communication of participants with (N  =  291) and without ASD (N  =  311). Participants with autism spectrum disorder (ASD) perceived benefits of computer-mediated communication in terms of increased comprehension and control over communication, access to similar others, and the opportunity to express their true selves. They enjoyed using the Internet to meet others more, and to maintain connections with friends and family less, than did participants without ASD. People with ASD enjoyed aspects of computer-mediated communication that may be associated with special interests or advocacy, such as blogging, more than did participants without ASD. This study suggests that people with ASD may use the Internet in qualitatively different ways from those without ASD. Suggestions for interventions are discussed.
Pholiotina cyanopus, a rare fungus producing
psychoactive tryptamines
Authors: Halama Marek , Poliwoda Anna , Jasicka-Misiak Izabela , Wieczorek Piotr P. , Rutkowski Ryszard 
Published: November 2014

Abstract

Pholiotina cyanopus was collected from wood
chips and other woody remnants of undetermined tree
species. Its basidiomata were found in June within the
area of closed sawmill in the central part of Żywiec city
(SW Poland). Description and illustration of Ph. cyanopus
based on Polish specimens are provided and its ecology,
general distribution and comparison with similar taxa –
Pholiotina smithii, Pholiotina sulcatipes, and others are
discussed as well. The identity of the active compounds
of Ph. cyanopus was additionally determined. Liquid
chromatography–mass spectrometry (LC-MS) data sets
were obtained to support the occurrence of psilocybin and
its analogues – psilocin, baeocystin, norbaeocystin, and
aeruginascin in air-dried basidiomata of the species. The
content of psilocybin was found to be high (0.90±0.08% of
dry weight), besides, analysed samples contained lower
concentrations of psilocin (0.17±0.01%), and baeocystin
(0.16±0.01%). Additionally, the chemical analysis revealed
small amounts of norbaeocystin (0.053±0.004%) and
aeruginascin (0.011±0.0007%) for the first time in the
species.
Oxytocin and callous-unemotional traits: towards a social-cognitive approach to forensic analysis
Authors: Rice Timothy R. , Derish Nicole E. 
Published: November 2014

Abstract
Callous-unemotional (CU) traits in children and adolescents are an important risk factor for forensic behaviors in youth and in adulthood. There is a strong biologic basis in CU traits, offering the possibility to design biological interventions to address this risk factor. This paper advances the hypothesis that the administration of exogenous oxytocin is a biological intervention worthy of further investigation to address CU traits and moderate future risk factors for forensic behaviors. The evidence for this assertion rests in the empiric evidence that social cognitive deficits play a major role in child and adolescent CU traits and psychopathy. Simultaneously, emerging evidence suggests that youth with CU traits have defined neuroendocrinological correlates within the oxytocin system. A review of the normal neurohormonal physiology of this system is presented to provide a groundwork for the delineation of these correlates. That deficits in this system are found in alternate psychopathologies that present with deficits in social cognition serves as the basis for the hypothesis that these deficits may play a key role in the development and manifestation of CU traits. Their correction through psychopharmacologic and alternate means may provide a future route to addressing a central area of adolescent forensic psychiatry.
Suicidal behavior in a medical professional with comorbid depression and substance use disorder: an educational case report
Authors: Kiraly Drew D. , Sher Leo 
Published: November 2014

Abstract
Here, we publish a report of a previously practicing nurse practitioner who presented to a community hospital with severely depressed mood and neurovegetative symptoms in the context of recent relapse to alcohol and cocaine abuse. This patient had a long history of depression and polysubstance abuse. Additionally, the patient had a history of multiple previous suicide attempts with a high possibility for lethality. All of his attempts occurred in the setting of depression, escalating substance use, and interpersonal difficulties. Due to his chronic struggles with mental health and substance abuse issues, the patient lost his marriage, many close friends, and, eventually, his license to practice medicine. In this report, we highlight the increased risk of suicidal behavior or completed suicide in patients with co-occurring depressive and substance abuse disorders. We also look to highlight the often unmet need of mental health and substance abuse treatment for healthcare professionals. Studies suggest that healthcare providers experience increasing rates of burnout, mood and anxiety disorders, and substance use disorders, but available treatment resources remain scarce. This is a serious public health issue that will require increased vigilance by the community at large to ensure the safety and wellbeing of both patients and their providers.
Coase, Hayek, Pigou and Walras: Taxes vs Permit Auctions in Environmental Policy
Authors: Dougan William R. , Thomas Charles J. 
Published: November 2014

Abstract
When policymakers are uncertain about the private costs of pollution abatement, using simple auctions that jointly determine the price and quantity of pollution permits enables them to set precisely the quantity of pollution they would choose if they knew abatement costs perfectly. Auctioning an endogenously determined number of tradable permits therefore yields greater expected net welfare than does a Pigovian tax that reflects policymakers’ best estimate of the efficient tax level. This conclusion holds regardless of polluters’ specific abatement-cost functions, which contrasts with the well-known analysis of Weitzman (1974) that compares the choice between taxing pollution and allocating a fixed number of permits when information is incomplete.
Genetic characterisation of a cohort of children clinically labelled as GH or IGF1 insensitive: diagnostic value of serum IGF1 and height at presentation
Authors: Storr Helen L , Dunkel Leo , Kowalczyk Julia , Savage Martin O , Metherell Louise A 
Published: November 2014

Objective and designGH insensitivity (GHI) encompasses growth failure, low serum IGF1 and normal/elevated serum GH. By contrast, IGF1 insensitivity results in pre- and postnatal growth failure associated with relatively high IGF1 levels. From 2008 to 2013, 72 patients from 68 families (45M), mean age 7.1 years (0.4–17.0) with short stature (mean height SDS −3.9; range −9.4 to −1.5), were referred for sequencing.MethodsAs a genetics referral centre, we have sequenced appropriate candidate genes (GHR, including its pseudoexon (6Ψ),STAT5B,IGFALS,IGF1,IGF1R,OBSL1,CUL7andCCDC8) in subjects referred with suspected GHI (n=69) or IGF1 insensitivity (n=3).ResultsMean serum IGF1 SDS was −2.7 (range −0.9 to −8.2) in GHI patients and 2.0, 3.7 and 4.4 in patients with suspected IGF1 insensitivity. Out of 69 GHI patients, 16 (23%) (19% families) had mutations in GH–IGF1 axis genes: homozygousGHR(n=13; 6 6Ψ, two novel IVS5ds+1 G to A) and homozygousIGFALS(n=3; one novel c.1291delT). In the GHI groups, two homozygousOBSL1mutations were also identified (height SDS −4.9 and −5.7) and two patients had hypomethylation in imprinting control region 1 in 11p15 or mUPD7 consistent with Silver–Russell syndrome (SRS) (height SDS −3.7 and −4.3). A novel heterozygousIGF1R(c.112G>A) mutation was identified in one out of three (33%) IGF1-insensitive subjects.ConclusionGenotyping contributed to the diagnosis of children with suspected GHI and IGF1 insensitivity, particularly in the GHI subjects with low serum IGF1 SDS (<−2.0) and height SDS (<−2.5). Diagnoses with similar phenotypes included SRS and 3-M syndrome. In 71% patients, no diagnosis was defined justifying further genetic investigation.
Ovarian macrocysts and gonadotrope–ovarian axis disruption in premenopausal women receiving mitotane for adrenocortical carcinoma or Cushing's disease
Authors: Salenave Sylvie , Bernard Valérie , Cao Christine Do , Guignat Laurence , Bachelot Anne , Leboulleux Sophie , Droumaguet Céline , Bry-Gauillard Hélène , Pierre Peggy , Crinière Lise , Santulli Pietro , Touraine Philippe , Chanson Philippe , Schlumberger Martin , Maiter Dominique , Baudin Eric , Young Jacques 
Published: November 2014

ContextMitotane is an adrenolytic and anticortisolic drug used in adrenocortical carcinoma (ACC), Cushing's disease (CD), and ectopic ACTH syndrome. Its effects on the ovaries are unknown.ObjectiveTo evaluate the ovarian and gonadotrope effects of mitotane therapy in premenopausal women.PatientsWe studied 21 premenopausal women (ACC: n=13; CD: n=8; median age 33 years, range 18–45 years) receiving mitotane at a median initial dose of 3 g/day (range 1.5–6 g/day).MethodsGynecological history was collected and ovarian ultrasound was performed. Four women also underwent ovarian CT or magnetic resonance imaging. Serum gonadotropin, estradiol (E2), androgens, sex hormone-binding globulin (SHBG), and circulating mitotane levels were determined at diagnosis and during mitotane therapy.ResultsIn the women included, ovarian macrocysts (bilateral in 51%) were detected after a median 11 months (range: 3–36) of mitotane exposure. The median number of macrocysts per woman was two (range: 1–4) and the median diameter of the largest cysts was 50 mm (range: 26–90). Menstrual irregularities and/or pelvic pain were present in 15 out of 21 women at macrocyst diagnosis. In two women, the macrocysts were revealed by complications (ovarian torsion and hemorrhagic macrocyst rupture) that required surgery. Mitotane therapy was associated with a significant decrease in androstenedione and testosterone levels and a significant increase in LH levels. Serum FSH and E2 levels were also increased, and SHBG levels rose markedly.ConclusionsMitotane therapy causes significant morphological and ovarian/gonadotrope hormonal abnormalities in premenopausal women. Follicular thecal steroid synthesis appears to be specifically altered and the subsequent increase in gonadotropins might explain the development of macrocysts. The mechanisms underlying these adverse effects, whose exact prevalence in this population still needs to be determined, are discussed.
Assessment and Treatment of Spasticity in Children with Cerebral Palsy
Authors: Dimitrijević Lidija , Čolović Hristina , Spalević Marija , Stanković Anita , Zlatanović Dragan , Cvetković Bratislav 
Published: November 2014

Summary
Spastic cerebral palsy (CP) is the most common type of CP. Up to 80% of all individuals with cerebral palsy suffer from some degree of spasticity. Spasticity adversely affects muscles and joints of the extremities, causing abnormal movements, and it is especially harmful in growing children.
Several methods have been developed and used to assess spasticity. The most commonly used test in clinical practice is the Modified Ashworth Scale (MAS). The test is based on the assessment of resistance to passive strech of muscle group at one nonspecified velocity.
Management of spasticity in CP involves multidisciplinary intervention intended to increase functionality, sustain health, and improve quality of life for children and their carers. This may include: oral medications, intrathecal medications, physiotherapy, occupational therapy, orthoses, surgical interventions, and pharmacological agents such as botulinum toxin.
Karyometric Analysis of Squamous Metaplasia, Dysplasia and Squamous Cell Carcinoma of the Lung
Authors: Mijović Žaklina , Pešić Zoran , Živković Nikola , Denčić Tijana , Petrović Ana Ristić , Stojnev Slavica 
Published: November 2014

Summary
The sequence of precursor lesions for squamous cell carcinoma may be hyperplasia-metaplasia-dysplasia-carcinoma in situ. The aim of this study was to perform a karyometric analysis of squamous metaplasia, moderate dysplasia and squamous cell lung carcinoma. Bronchoscopic biopsies of normal mucosa in chronic bronchitis patients (n=10), squamous metaplasia (n=10), moderate dysplasia (n=11), squamous cell lung carcinoma (n=48), and normal appearing mucosa surrounding carcinoma (n=11) were retrieved. Three nuclear variables were estimated using an image analysis system. The mean equivalent diameter, nuclear area and volume of equivalent sphere of squamous cell lung carcinoma were significantly larger than in moderate dysplasia, squamous metaplasia and normal bronchial mucosa. Also, the values of equivalent diameter, nuclear area and volume of equivalent sphere were significantly larger in normal appearing mucosa surrounding carcinoma compared to normal mucosa in chronic bronchitis patients. Karyometric analysis may be a helpful ancillary tool in distinguishing squamous cell lung carcinoma from dysplasia, and dysplasia from squamous metaplasia in bronchoscopic biopsy specimens.
Influence of Chemical Fertilizers Application on Autumn Wheat Yield in Long-Term Experiences at Agricultural Research and Development Secuieni, Neamţ County, Romania
Authors: Lupu Cornelia , Druţu Cătălina , Popa Lorena-Diana , Naie Margareta 
Published: November 2014

Abstract
The current paper intends to interpret from a technical point of view the data and yield functions which resulted from applying different fertilizer doses with nitrogen and phosphorus. The analyzed parameters (yield, yield increase, marginal increase) represent basic elements with determining role in establishing the doses and approximating the economic efficiency when applying fertilizers. The data comes from a long time experience with chemical fertilizers at Agricultural Research and Development Station (A.R.D.S.) Secuieni, Neamţ county, Romania, since 1975 and examines the results obtained between 2010-2012. As a result of nitrogen and phosphorus chemical fertilizers application (compared to the unfertilized version N0P0), were achieved yield increases of 5-56%, representing 234-2342 kg/ha. The resulted yield have been influenced by the fertilizer’s type but also by the weather conditions in the research period. The use of phosphorus fertilizers in doses of P40-P160 brought medium yield increases compared to the unfertilized version P0 of 5-13% representing 256-681 kg/ha, and those with N40-N160 nitrogen brought medium increases (compared to the unfertilized version N0) of 15 -35% representing 599-1584 kg/ha. The production increases were directly correlated with the doses used, establishing highly significant correlations. The yield increases achieved by applying 1 kg of fertilizer active matter had medium values of 4.25-8.82 kg wheat/kg active matter P2O5 at phosphorus fertilizers and 9.9-14.97 kg wheat/kg active matter N at nitrogen fertilizers. These increases were indirectly correlated with the applied doses.
Assessment of Genetic Diversity of Some Wild Populations of Thymus Kotschyanus Usingrapd Molecular Markers
Authors: Khoshsokhan F. , Babalar M. , Fatahi M. , Poormeidani A. 
Published: November 2014

Abstract
RAPD molecular markers were used to assess the genetic diversity of some population of thyme (Thymus kotschyanus) from Iran. The 17 tennucleotide primers used that produced 185 high-resolution bands, which 21 of these were monomorphic and 162 were polymorphic. An average, 10.88 bands were obtained per primer and 9.52 of these were polymorphic. POPGENE software was used to calculate Nei's genetic distance among populations and based on the cluster analysis of this matrix, a UPGMA dendrogram was drawn using the software NTSYS-pc. On the basis of dendrogram among populations of wild mountain thyme, Avan (Qazvin) and Siahkal (Gilan province) populations was the most similar between studied populations with the distance of 0.094 high disimilarity was observed between Qazvin and Mazandaran 2 populations with the distance of 0.185 within populations variation based on Shannon's information index and Nei genetic diversity index showed that Takestan (I= 0.26; H= 0.3) and Alamut (I= 0.24; H= 0.15) had a highest and lowest within populations variation compared to other populations, respectively. Average of Fst and Nm indices, which represent the amount of gene flow between populations, were recorded as 0.26 and 1.361, respectively, which reflects the high level of gene exchange between ten populations of Thymus kotschyanus.
Preliminary investigation to estimate soil NAPL retention using parametric pedotransfer functions
Authors: Hernádi Hilda , Makó András 
Published: November 2014

Abstract
Organic liquid retention of soils is a primary input variable for modelling the nonaqueous phase liquid transport and behaviour in the subsurface. In environmental and soil physical practice, it is mainly determined by scaling based on the water retention of soils or with charts of average empirical values of organic liquid retention or the fitting parameters of hydraulic functions. Predicting the fitting parameters of organic liquid retention curves with pedotransfer functions might be a promising alternative method, but this topic has only been researched to a limited extent. Thus we investigated the applicability of different hydraulic functions (3- and 4- parameter form of the van Genuchten equation and Brutsaert equation) for fitting organic liquid retention characteristics. Multivariate linear regression was used to build and develop pedotransfer functions, modelling relations between original and transformed values of basic soil properties and organic liquid retention. We attempted to generate parametric pedotransfer functions. According to our results, the applicability of hydraulic functions for fitting nonaqueous phase liquid retention curves to the experimental data was proven. The investigations gave promising results for the possibility to estimate soil nonaqueous phase liquid retention with parametric pedotransfer functions.
Innovation and Quality: Drivers of Successful Ventures that Seek Success in Catering to Consumers who Live in Poverty
Authors: Chattopadhyay Satya P. 
Published: November 2014

Abstract
The next big challenge in a global marketplace is to engage the very large segment of world population which survives on less income than the defined poverty level by any measurements that may be applied. This segment in the past has been the focus of aid and charities and been at the receiving end of poverty alleviation programs created by a variety of international donor agencies, with very limited success. It is time now to take a different approach. A radical re-thinking of the problem now has resulted in a novel approach: that of engaging them as customers like any other. The underlying assumption is that folks in this segment still spend billions of dollars in the aggregate and are now able to critically examine offerings and choose to go after quality and value just like any other segment. The opportunity to tap into this huge market lies in innovative entrepreneurial efforts that make goods and services available to this segment without compromising on performance and quality. This paper explores the nature of innovation that is likely to result in entrepreneurial success in what is called the Base (Bottom) of the Pyramid marketplace.
Developing a Customer Relationship Management Model for Better Health Examination Service
Authors: Lyu Jr-Jung , Chao Hai-Lun , Chen Chia-Wen , Huang Li-Yu 
Published: November 2014

Abstract
People emphasize on their own health and wish to know more about their conditions. Chronic diseases now take up to 50 percent of top 10 causes of death. As a result, the health-care industry has emerged and kept thriving. This work adopts a customer-oriented business model since most clients are proactive and spontaneous in taking the “distinguished” health examination programs. We adopt the soft system dynamics methodology (SSDM) to develop and to evaluate the steps of introducing customer relationship management model into a case health examination organization. Quantitative results are also presented for a case physical examination center and to assess the improved efficiency. The case study shows that the procedures developed here could provide a better service.
The Business Excellence Model for CSR Implementation?
Authors: Neergaard Peter , Pedersen Esben Rahbek 
Published: November 2014

Abstract
Most of the Fortune 500 companies address Corporate Social Responsibility (CSR) on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating quality in organizations. CSR was first introduced in the model in 2002. From 2004 the European Foundation for Quality Management (EFQM) has been eager to promote the model as an effective tool for implementing CSR.. The article discusses the potentials of the model for this end and illustrates how a 2006 European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus.