bluuebunny/crossref_metadata_2025_split huggingface dataset:
HLA typing in autoimmune diseases
Authors: Martinescu Alina , Franciuc Irina , Aftenie Loredana-Mariana 
Published: March 2013

Abstract
Genome scan, linkage and association studies have identified CMH genes in the genetic determinism of most autoimmune diseases, affecting approximately 5% of the population. The susceptibility conferred by HLA alleles does not influence the development of autoimmunity in general, but rather the probability of some disorders. From extremely high number of known HLA alleles, less than 30 are associated with diseases, and fewer than 10 are involved in the strongest associations. The aim of this study was to determine HLA genes in autoimmune diseases. The method used for the assignment of HLA alleles was molecular genotyping, primarily by the sequence specific oligonucleotide hybridization method (SSO), and when required, by the sequence specific primers method (SSP). Molecular genotyping was performed in 282 cases of diabetes mellitus type 1, Hashimoto thyroiditis, Graves’ disease and ankylosing spondylitis. HLA typing in patients with autoimmune diseases is important for determining prognosis and genetic counseling. In ankylosing spondylitis HLA typing is used for differential diagnosis. In such studies it’s important to be aware that there is a particular HLA gene expression depending on the geographic area.
Incidence, epidemiology and etiology of acute meningitis in Mures County – an observational study
Authors: Tilea Brindusa , Brînzaniuc Klara , Tilea I. 
Published: March 2013

Abstract
Background: Meningitis are multiple aetiology disorders characterized by infectious triggered inflammation of the meningeal serrosa manifesting as an acute systemic illness with variable evolution from cure to death. The objectives of this study were the evaluation of incidence, epidemiologic and diagnostic aspects of the acute meningitis in a well define region.
Methods: we have designed an observational retrospective study that included a number of 165 consecutively admitted patients with the diagnosis of meningitis at the Targu-Mures Infectious Disease Clinic, Romania, from January 1st to December 31st 2011. We have compared cases of confirmed meningitis vs. meningismus, and meningeal reaction. We kept track of the demographic aspects, the annual and seasonal distribution of cases. The diagnosis of meningitis was established by examination of the cerebrospinal fluid such as: aspect, pleocytosis, biochemical reactions, wet mounts, Latex agglutination tests, serological reactions, cultures and antibiotic resistance testing (when needed). Results: the majority of the patients were male, from rural areas. The mean age of patients with bacterimeningitis was 36 years old, and that of viral meningitis cases was 20 years old. The acute meningitis incidence in 2011 was 19.73 cases/100.000 inhabitants. 26 patients (15.76%) of the observed group were diagnosed with bacterial meningitis, and 63 cases (38.18%) with viral meningitis. The most common cause for bacterial meningitis were Gram-positive cocci, and for viral meningitis, the varicella-zoster virus.
Conclusions: in 2011, the incidence of acute meningitis in our region has not decreased significantly compared to previous studies. In the case of bacterial meningitis, the etiologic agent was identified in a small proportion, possibly because of antibiotic treatment administered before the admission, also observing an increase in antibiotic resistance of the identified agents.
Incomplete stent apposition in Enterprise stent–mediated coiling of aneurysms: persistence over time and risk of delayed ischemic events
Authors: Heller Robert , Calnan Daniel R. , Lanfranchi Michael , Madan Neel , Malek Adel M. 
Published: March 2013

Object
Incomplete stent apposition of the closed cell–design Enterprise stent following stent-mediated coil embolization of intracranial aneurysms has been associated with increased risk of periprocedural thromboembolic events. In this study, the authors seek to determine the natural history of incomplete stent apposition and evaluate the clinical implications of the phenomenon.

Methods
Since January 2009, all patients receiving Enterprise stents in the treatment of intracranial aneurysms at the authors' institution have undergone serial 3-T MRI with incomplete stent apposition identified by the crescent sign on multiplanar reconstructions of MR angiograms. Magnetic resonance images and MR angiograms obtained at 3, 9, and 18 months after stent-assisted coil embolization were analyzed along with admission and follow-up clinical medical records. These records were evaluated for any radiographic and clinical, transient or permanent ischemic neurological events.

Results
Fifty patients receiving Enterprise stents were eligible for inclusion and analysis in the study. Incomplete stent apposition was identified in postoperative imaging studies in 22 (44%) of 50 patients, with 19 (86%) of 22 crescent signs persisting and 3 (14%) of 22 crescent signs resolving on subsequent serial imaging. Delayed ischemic events occurred in 8 (16%) of 50 cases, and all cases involved patients with incomplete stent apposition. The events were transient ischemic attacks (TIAs) in 5 cases, asymptomatic radiographic strokes in 2 cases, and symptomatic strokes and TIAs in the final case. There were no delayed ischemic events in patients who did not have incomplete stent apposition. Only 1 of the delayed ischemic events (2%) was permanent and symptomatic. The postoperative presence of a crescent sign and persistence of the crescent sign were both significantly associated with delayed ischemic events (p < 0.001 and p = 0.002, respectively).

Conclusions
Incomplete stent apposition is a temporally persistent phenomenon, which resolves spontaneously in only a small minority of cases and appears to be a risk factor for delayed ischemic events. Although further follow-up is needed, these results suggest that longer duration of antiplatelet therapy and clinical follow-up may be warranted in cases of recognized incomplete stent apposition.
Surgical treatment of transsphenoidal encephaloceles: transpalatal versus combined transpalatal and transcranial approach
Authors: Ogiwara Hideki , Morota Nobuhito 
Published: March 2013

Object
Transsphenoidal encephalocele (TSEC) is a rare developmental anomaly with herniation of neural elements including pituitary gland or optic apparatus, through a defect of sphenoid bone. To prevent obstructive dyspnea, endocrine dysfunction, or visual disturbance, surgical correction is usually performed. However, the optimal operative approach has not been determined yet. The authors present their surgical experiences with transpalatal, transcranial, or combined approach.

Methods
The authors retrospectively analyzed surgical results in patients with TSEC. The charts were reviewed for demographic data, clinical presentation, surgical therapy, and clinical outcomes.

Results
Seven consecutive patients with TSEC were surgically treated between March 2004 and February 2012. The mean age was 23.9 months (range 2–69 months). Four patients with TSEC who had a bone defect within the sphenoid bone were successfully treated using a transpalatal approach. Two patients with an extensive sphenoethmoidal bone defect that was treated either by a transpalatal or transcranial approach experienced several relapses with a prolapse of the encephalocele. One patient with an extensive sphenoethmoidal bone defect was successfully treated by combined transpalatal and transcranial approach without relapse for 3.6 years.

Conclusions
The combined transpalatal and transcranial approach is useful for TSEC with an extensive sphenoethmoidal bone defect to dissect the sac and expose the bone defect circumferentially. If dissection is not sufficient, relapse with a prolapse of the encephalocele can ensue. The transpalatal approach is sufficient for TSEC in which a bone defect is limited within the sphenoid bone.
Myelopathy due to calcified meningiomas of the thoracic spine: minimum 3-year follow-up after surgical treatment
Authors: Zhu Qing , Qian Ming , Xiao Jianru , Wu Zhipeng , Wang Yu , Zhang Jishen 
Published: March 2013

Object
Calcified meningiomas are an uncommon type of meningioma. This study details the clinical features, treatment, and follow-up of 11 calcified meningiomas treated from 2002 to 2009, for the purpose of providing general information, describing the skill required for the surgery, and detailing the imaging study of these tumors.

Methods
Between 2002 and 2009, 11 patients underwent surgery for the treatment of calcified meningiomas. All were treated by the same group of doctors at the same institution, including surgery and rehabilitation after surgery. The minimum 3-year (> 36 months) follow-up data from the 11 patients were detailed. Neurological function was evaluated twice, based on the Frankel scale and Japanese Orthopaedic Association scoring system. The first evaluation occurred before surgery and the second 3 years after surgery.

Results
In 3 cases, the Frankel score decreased by 1 level. In a comparison of the duration of preoperative symptoms, age, degree of canal stenosis, and intraoperative blood loss, it was found that the greater the degree of canal stenosis, the poorer the outcome of the patient. Calcified meningiomas were more likely to adhere to the nerves and dura, a finding that might explain the high incidence of neurological dysfunction and CSF leakage after surgery.

Conclusions
Calcified meningiomas are the most rare of all meningiomas. It appears that a greater degree of canal stenosis can lead to a poorer outcome. Computed tomography scans and MRI with contrast enhancement are recommended for intraspinal tumors before surgery to exclude the possibility of calcification. For calcified meningiomas, precise tumor resection, dura repair during surgery, and medical care after surgery are important for achieving an acceptable outcome.
Le travail, sa valeur et la gauche
Authors: Vicherat Denis 
Published: March 2013

Travail, valeur travail, gauche : trois notions apparemment simples, mais qui font l’objet de controverses et d’interprétations variables, surtout lorsqu’on les juxtapose. Commençons donc par définir, en acceptant une part de convention, ce que nous entendons par ces trois termes.
Des « coopératives municipales » pour des travailleurs « autonomes »
Authors: Zin Jean 
Published: March 2013

Toutes les versions du revenu garanti ne se valent pas, exprimant au contraire toute une gamme de projets différents. On ne peut donner un sens à un dispositif isolé que si on lui fait jouer un rôle dans l’organisation sociale. Ce qui peut aller, pour un revenu garanti, de la simple mesure sociale, d’un palliatif au marché du travail assurant juste une consommation minimum, jusqu’à l’élément d’un nouveau système de production relocalisé qui change la façon de produire en donnant accès au « travail choisi ».
Pour une théorie non subjectiviste de la subjectivité : Jacques Lacan relu par Michel Pêcheux
Authors: Gillot Pascale 
Published: March 2013

J’examine dans cet article les enjeux de la « réinscription non idéaliste » de la pensée de Jacques Lacan, dans ce courant de la philosophie française marqué par le travail de Louis Althusser, et sa théorie de l’idéologie. J’explore plus particulièrement dans ce but l’« analyse du discours » proposée dans les années 1970 par Michel Pêcheux, sous la double influence d’Althusser et de Lacan, et destinée à promouvoir une théorie non subjectiviste de la subjectivité.
L'étiologie psychanalytique en criminologie dans l'œuvre de Lacan
Authors: Kaltenbeck Franz 
Published: March 2013

Dans ses « Complexes familiaux » (1938), Lacan a commencé à élaborer les concepts nécessaires pour analyser l’envie. Plus efficaces que ceux de Melanie Klein, ils nous aident à éclairer certains crimes dont des agressions sexuelles. Ainsi, nous découvrons chez des sujets, dans l’anamnèse de leurs psychoses et perversions, pour les agressions sexuelles commises plus tard dans leur vie, l’impact d’une rivalité indépassable vis-à-vis d’un frère. Mais l’envie n’est pas seulement un affect individuel. Pour l’historien Götz Aly, c’est l’envie des Allemands à l’égard des juifs qui est à l’origine d’une haine ayant abouti à la Shoah. L’appareil théorique mis à notre disposition par Lacan nous permet de tenir compte de ces manifestations individuelles et collectives de l’envie.
Intacs Followed by MyoRing Implantation in Severe Keratoconus
Authors: Behrouz Mahmoud Jabbarvand , Hashemian Hesam , Khodaparast Mehdi , Rad Ahmad Salamat , Shadravan Mahla 
Published: March 2013

PURPOSE:
To describe the outcome of complete intrastromal ring (MyoRing, DIOPTEX GmBH, Linz, Austria) implantation following intrastromal corneal ring segment (Intacs, Addition Technology, Inc., Sunnyvale, CA) implantation for severe keratoconus.

METHODS:
Case report.

RESULTS:
A MyoRing was implanted in a keratoconic patient who had undergone a previous Intacs implantation surgery 4 years previously without Intacs explantation and had residual refractive error. There were no intraoperative or postoperative complications. After 1 year; mean keratometric power decreased from 50.3 to 43.6 diopters, uncorrected distance visual acuity improved from 20/400 to 20/50, and corrected distance visual acuity improved from 20/200 to 20/30.

CONCLUSIONS:
In selected severe keratoconus cases with high myopia and steep keratometry previously treated with Intacs implantation, if significant residual refractive error is observed, secondary implantation of MyoRing over Intacs may improve vision and refraction.

[
J Refract Surg.
2013;29(5):364–366.]
Corneal Ectasia Secondary to LASIK After Arcuate Keratotomy
Authors: Ghanem Ramon C. , Ghanem Marcielle A. , Bogoni Ayla , Ghanem Vinícius C. 
Published: March 2013

PURPOSE:
To present a case of corneal ectasia after LASIK in a patient with previous arcuate keratotomy.

METHODS:
Case report.

RESULTS:
The patient underwent arcuate keratotomy in both eyes in 1997 for with-the-rule regular hyperopic astigmatism and uneventful bilateral LASIK for residual astigmatism 5 years later. Visual acuity and refraction remained stable for 5 years, when the patient noticed worsening visual acuity. Corneal topography showed progressive inferior steepening, confirming the diagnosis of ectasia. Corneal high-resolution optical coherence tomography revealed a normal LASIK flap. The patient had no risk factors for corneal ectasia other than previous incisional surgery.

CONCLUSIONS:
This case suggests that isolated arcuate keratotomy can be a significant risk factor for the development of corneal ectasia after LASIK.

[
J Refract Surg.
2013;29(6):426–429.]
Dehydration and Performance on Clinical Concussion Measures in Collegiate Wrestlers
Authors: Weber Amanda Friedline , Mihalik Jason P. , Register-Mihalik Johna K. , Mays Sally , Prentice William E. , Guskiewicz Kevin M. 
Published: March 2013

Context:
The effects of dehydration induced by wrestling-related weight-cutting tactics on clinical concussion outcomes, such as neurocognitive function, balance performance, and symptoms, have not been adequately studied.

Objective:
To evaluate the effects of dehydration on the outcome of clinical concussion measures in National Collegiate Athletic Association Division I collegiate wrestlers.

Design:
Repeated-measures design.

Setting:
Clinical research laboratory.

Patients or Other Participants:
Thirty-two Division I healthy collegiate male wrestlers (age = 20.0 ± 1.4 years; height = 175.0 ± 7.5 cm; baseline mass = 79.2 ± 12.6 kg).

Intervention(s):
Participants completed preseason concussion baseline testing in early September. Weight and urine samples were also collected at this time. All participants reported to prewrestling practice and postwrestling practice for the same test battery and protocol in mid-October. They had begun practicing weight-cutting tactics a day before prepractice and postpractice testing. Differences between these measures permitted us to evaluate how dehydration and weight-cutting tactics affected concussion measures.

Main Outcome Measures:
Sport Concussion Assessment Tool 2 (SCAT2), Balance Error Scoring System, Graded Symptom Checklist, and Simple Reaction Time scores. The Simple Reaction Time was measured using the Automated Neuropsychological Assessment Metrics.

Results:
The SCAT2 measurements were lower at prepractice (P = .002) and postpractice (P &lt; .001) when compared with baseline. The BESS error scores were higher at postpractice when compared with baseline (P = .015). The GSC severity scores were higher at prepractice (P = .011) and postpractice (P &lt; .001) than at baseline and at postpractice when than at prepractice (P = .003). The number of Graded Symptom Checklist symptoms reported was also higher at prepractice (P = .036) and postpractice (P &lt; .001) when compared with baseline, and at postpractice when compared with prepractice (P = .003).

Conclusions:
Our results suggest that it is important for wrestlers to be evaluated in a euhydrated state to ensure that dehydration is not influencing the outcome of the clinical measures.
Pancreatic Laceration in a Female Collegiate Soccer Athlete: A Case Report
Authors: Powers Michael E. , Tropeano Michelle , Priestman Diana 
Published: March 2013

Objective:To characterize the diagnosis of pancreatic trauma in an athletic population and to raise awareness among health care providers of the possibility of this life- and organ-threatening injury.Background:An 18-year-old, previously healthy female collegiate soccer athlete sustained a direct blow from an opponent's knee between the left and right upper abdominal quadrants while attempting to head the ball. She initially presented with only minimal nausea and discomfort, but this progressed to abdominal pain, tenderness, spasm, and vomiting. She was referred to the emergency department, where she was diagnosed with a pancreatic laceration.Differential Diagnosis:Duodenal, hepatic, or splenic contusion or laceration; hemorrhagic ovarian cyst.Treatment:The patient underwent a distal pancreatectomy and total splenectomy.Uniqueness:Pancreatic injuries, particularly those severe enough to warrant surgical intervention, are extremely rare in athletes.Conclusions:Recognition of a pancreatic injury can be very challenging outside the hospital setting. This is problematic, because a delay in diagnosis is a significant source of preventable morbidity and mortality after this rare injury. Thus, early identification depends on a high index of suspicion, a thorough examination, and close observation. It is imperative that athletic trainers and other health care professionals be able to identify this condition so that referral and management can occur without delay.
High School Automated External Defibrillator Programs as Markers of Emergency Preparedness for Sudden Cardiac Arrest
Authors: Toresdahl Brett G. , Harmon Kimberly G. , Drezner Jonathan A. 
Published: March 2013

Context:
School-based automated external defibrillator (AED) programs have demonstrated a high survival rate for individuals suffering sudden cardiac arrest (SCA) in US high schools.

Objective:
To examine the relationship between high schools having an AED on campus and other measures of emergency preparedness for SCA.

Design:
Cross-sectional study.

Setting:
United States high schools, December 2006 to September 2009.

Patients or Other Participants:
Principals, athletic directors, school nurses, and certified athletic trainers represented 3371 high schools.

Main Outcome Measure(s):
Comprehensive surveys on emergency planning for SCA submitted by high school representatives to the National Registry for AED Use in Sports from December 2006 to September 2009. Schools with and without AEDs were compared to assess other elements of emergency preparedness for SCA.

Results:
A total of 2784 schools (82.6%) reported having 1 or more AEDs on campus, with an average of 2.8 AEDs per school; 587 schools (17.4%) had no AEDs. Schools with an enrollment of more than 500 students were more likely to have an AED (relative risk [RR] = 1.12, 95% confidence interval [CI] = 1.08, 1.16, P &lt; .01). Suburban schools were more likely to have an AED than were rural (RR = 1.08, 95% CI = 1.04, 1.11, P &lt; .01), urban (RR = 1.13, 95% CI = 1.04, 1.16, P &lt; .01), or inner-city schools (RR = 1.10, 95% CI = 1.04, 1.23, P &lt; .01). Schools with 1 or more AEDs were more likely to ensure access to early defibrillation (RR = 3.45, 95% CI = 2.97, 3.99, P &lt; .01), establish an emergency action plan for SCA (RR = 1.83, 95% CI = 1.67, 2.00, P &lt; .01), review the emergency action plan at least annually (RR = 1.99, 95% CI = 1.58, 2.50, P &lt; .01), consult emergency medical services to develop the emergency action plan (RR = 1.18, 95% CI = 1.05, 1.32, P &lt; .01), and establish a communication system to activate emergency responders (RR = 1.06, 95% CI = 1.01, 1.08, P &lt; .01).

Conclusions:
High schools with AED programs were more likely to establish a comprehensive emergency response plan for SCA. Implementing school-based AED programs is a key step associated with emergency planning for young athletes with SCA.
Graduated Compression Stockings for Runners: Friend, Foe, or Fake?
Authors: Bovenschen H. Jorn , Booij Mariëlle te , van der Vleuten Carine J. M. 
Published: March 2013

Objective:
To assess the effect of graduated compression stockings (GCS) on lower leg volume and leg complaints in runners during and after exercise.

Design:
Cross-sectional study.

Setting:
Radboud University Nijmegen Medical Centre and an outdoor running track in Nijmegen, The Netherlands.

Patients or Other Participants:
Thirteen Dutch trained recreational runners.

Intervention(s):
Participants used a GCS on 1 leg during running.

Main Outcome Measures:
(1) Lower leg volume of both legs was measured at baseline, directly after running, and at 5 minutes and 30 minutes after running using a validated perometer. (2) Leg complaints were reported on questionnaires at set intervals.

Results:
(1) In both experiments, the legs with GCS showed a reduction in mean (± SEM) leg volume directly after running, as compared with the leg without GCS: −14.1 ± 7.6 mL (P = .04) for the 10-km running track and −53.5 ± 17.8 mL (P = .03) for the maximum exercise test. This effect was not observed at 5 and 30 minutes after running. (2) No differences in leg complaints were reported in either experiment.

Conclusions:
The GCS prevented an increase in leg volume just after the running exercise. However, this result was not accompanied by a reduction in subjective questionnaire-reported leg complaints. The practical consequences of the present findings need further study.