bluuebunny/crossref_metadata_2025_split huggingface dataset:
National Cancer Institute-funded grants focused on synchronous telehealth cancer care delivery: a portfolio analysis
Authors: Jensen Roxanne E , Brick Rachelle , Medel Joshua , Tuovinen Priyanga , Jacobsen Paul B , Hardesty Rebecca , Vanderpool Robin C 
Published: June 2024

Abstract

Background
Telehealth use increased during the COVID-19 pandemic and remains a complementary source of cancer care delivery. Understanding research funding trends in cancer-related telehealth can highlight developments in this area of science and identify future opportunities.

Methods
Applications funded by the US National Cancer Institute (NCI) between fiscal years 2016 and 2022 and focused on synchronous patient-provider telehealth were analyzed for grant characteristics (eg, funding mechanism), cancer focus (eg, cancer type), and study features (eg, type of telehealth service). Of 106 grants identified initially, 60 were retained for coding after applying exclusion criteria.

Results
Almost three-quarters (73%) of telehealth grants were funded during fiscal years 2020-2022. Approximately 67% were funded through R01 or R37 mechanism and implemented as randomized controlled trials (63%). Overall, telehealth grants commonly focused on treatment (30%) and survivorship (43%); breast cancer (12%), hematologic malignancies (10%), and multiple cancer sites (27%); and health disparity populations (ie, minorities, rural residents) (73%). Both audio and video telehealth were common (65%), as well as accompanying mHealth apps (20%). Telehealth services centered on psychosocial care, self-management, and supportive care (88%); interventions were commonly delivered by mental health professionals (30%).

Conclusion
NCI has observed an increase in funded synchronous patient-provider telehealth grants. Trends indicate an evolution of awards that have expanded across the cancer control continuum, applied rigorous study designs, incorporated additional digital technologies, and focused on populations recognized for disparate cancer outcomes. As telehealth is integrated into routine cancer care delivery, additional research evidence will be needed to inform clinical practice.
University of Pennsylvania Telehealth Research Center of Excellence
Authors: Wainwright Jocelyn V , Aggarwal Charu , Beucker Sarah , Dougherty David W , Gabriel Peter E , Jacobs Linda A , Kalman Jillian , Linn Kristin A , Martella Anthony O , Mehta Shivan J , Rhodes Corinne M , Roy Megan , Schapira Marilyn M , Shulman Lawrence N , Steltz Jennifer , Stephens Shields Alisa J , Tan Andy S L , Thompson Jeffrey C , Toneff Hannah , Wender Richard C , Zeb Sana , Rendle Katharine A , Vachani Anil , Bekelman Justin E ,   Penn TRACE, Aggarwal Charu , Asch David A , Bekelman Justin E , Beucker Sarah , Bradbury Angela , Cook Tessa , Dougherty David W , Gabriel Peter E , Glanz Karen , Guerra Carmen , Hubbard Rebecca , Huffenberger Ann , Jacobs Linda A , Johnson Kevin B , Kalman Jillian , Kumar Pallavi , Leone Frank , Linn Kristin A , Long Judith A , Martella Anthony O , McGinley Susan , Mehta Shivan J , O’Malley Christina J , Press Matthew J , Rendle Katharine A , Rhodes Corinne M , Ritzwoller Debra P , Roy Megan , Schapira Marilyn M , Schnoll Robert , Shulman Lawrence N , Steltz Jennifer , Shields Alisa J Stephens , Takvorian Samuel , Tan Andy S L , Teel Joseph , Thompson Jeffrey C , Toneff Hannah , Vachani Anil , Wainwright Jocelyn V , Wender Richard C , Zeb Sana 
Published: June 2024

Abstract
Drawing from insights from communication science and behavioral economics, the University of Pennsylvania Telehealth Research Center of Excellence (Penn TRACE) is designing and testing telehealth strategies with the potential to transform access to care, care quality, outcomes, health equity, and health-care efficiency across the cancer care continuum, with an emphasis on understanding mechanisms of action. Penn TRACE uses lung cancer care as an exemplar model for telehealth across the care continuum, from screening to treatment to survivorship. We bring together a diverse and interdisciplinary team of international experts and incorporate rapid-cycle approaches and mixed methods evaluation in all center projects. Our initiatives include a pragmatic sequential multiple assignment randomized trial to compare the effectiveness of telehealth strategies to increase shared decision-making for lung cancer screening and 2 pilot projects to test the effectiveness of telehealth to improve cancer care, identify multilevel mechanisms of action, and lay the foundation for future pragmatic trials. Penn TRACE aims to produce new fundamental knowledge and advance telehealth science in cancer care at Penn and nationally.
Telehealth Research and Innovation for Veterans with Cancer: the THRIVE Center
Authors: Zullig Leah L , Makarov Danil , Becker Daniel , Dardashti Navid , Guzman Ivonne , Kelley Michael J , Melnic Irina , Juarez Padilla Janeth , Rojas Sidney , Thomas Jerry , Tumminello Christa , Sherman Scott E 
Published: June 2024

Abstract

Background
In recent years the US health-care system has witnessed a substantial increase in telehealth use. Telehealth enhances health-care access and quality and may reduce costs. However, there is a concern that the shift from in-person to telehealth care delivery may differentially improve cancer care access and quality in certain clinical settings and for specific patient populations while potentially exacerbating disparities in care for others. Our National Cancer Institute–funded center, called Telehealth Research and Innovation for Veterans with Cancer (THRIVE), is focused on health equity for telehealth-delivered cancer care. We seek to understand how social determinants of telehealth—particularly race and ethnicity, poverty, and rurality—affect the use of telehealth.

Methods
THRIVE draws from the Health Disparities Research Framework and the Consolidated Framework for Implementation Research. THRIVE consists of multiple cores that work synergistically to assess and understand health equity for telehealth-delivered cancer care. These include the Administrative Core, Research and Methods Core, Clinical Practice Network, and Pragmatic Trial.

Results
As of October 2023, we identified and trained 5 THRIVE scholars, who are junior faculty beginning a research career. We have reviewed 20 potential pilot studies, funding 6. Additionally, in communication with our funders and advisory boards, we have adjusted our study design and analytic approach, ensuring feasibility while addressing our operational partners’ needs.

Conclusions
THRIVE has several key strengths. First, the Veterans Health Administration’s health-care system is large and diverse regarding health-care setting type and patient population. Second, we have access to longitudinal data, predating the COVID-19 pandemic, about telehealth use. Finally, equitable access to high-quality care for all veterans is a major tenet of the Veterans Health Administration health-care mission. As a result of these advantages, THRIVE can focus on isolating and evaluating the impact of social determinants of telehealth on equity in cancer care.
Scalable Telehealth Cancer Care: integrated healthy lifestyle program to live well after cancer treatment
Authors: Spring Bonnie , Garcia Sofia F , Daly Elyse , Jacobs Maia , Jayeoba Monisola , Jordan Neil , Kircher Sheetal , Kocherginsky Masha , Mazzetta Rana , Pollack Teresa , Scanlan Laura , Scherr Courtney , Hitsman Brian , Phillips Siobhan M 
Published: June 2024

Abstract
Northwestern University’s Center for Scalable Telehealth Cancer Care (STELLAR) is 1 of 4 Cancer Moonshot Telehealth Research Centers of Excellence programs funded by the National Cancer Institute to establish an evidence base for telehealth in cancer care. STELLAR is grounded in the Institute of Medicine’s vision that quality cancer care includes not only disease treatment but also promotion of long-term health and quality of life (QOL). Cigarette smoking, insufficient physical activity, and overweight and obesity often co-occur and are associated with poorer treatment response, heightened recurrence risk, decreased longevity, diminished QOL, and increased treatment cost for many cancers. These risk behaviors are prevalent in cancer survivors, but their treatment is not routinely integrated into oncology care. STELLAR aims to foster patients’ long-term health and QOL by designing, implementing, and sustaining a novel telehealth treatment program for multiple risk behaviors to be integrated into standard cancer care. Telehealth delivery is evidence-based for health behavior change treatment and is well suited to overcome access and workflow barriers that can otherwise impede treatment receipt. This paper describes STELLAR’s 2-arm randomized parallel group pragmatic clinical trial comparing telehealth-delivered, coach-facilitated multiple risk behavior treatment vs self-guided usual care for the outcomes of reach, effectiveness, and cost among 3000 cancer survivors who have completed curative intent treatment. This paper also discusses several challenges encountered by the STELLAR investigative team and the adaptations developed to move the research forward.
A Framework for Integrating Telehealth Equitably across the cancer care continuum
Authors: Rendle Katharine A , Tan Andy S L , Spring Bonnie , Bange Erin M , Lipitz-Snyderman Allison , Morris Michael J , Makarov Danil V , Daly Robert , Garcia Sofia F , Hitsman Brian , Ogedegbe Olugbenga , Phillips Siobhan , Sherman Scott E , Stetson Peter D , Vachani Anil , Wainwright Jocelyn V , Zullig Leah L , Bekelman Justin E 
Published: June 2024

Abstract
The COVID-19 pandemic placed a spotlight on the potential to dramatically increase the use of telehealth across the cancer care continuum, but whether and how telehealth can be implemented in practice in ways that reduce, rather than exacerbate, inequities are largely unknown. To help fill this critical gap in research and practice, we developed the Framework for Integrating Telehealth Equitably (FITE), a process and evaluation model designed to help guide equitable integration of telehealth into practice. In this manuscript, we present FITE and showcase how investigators across the National Cancer Institute’s Telehealth Research Centers of Excellence are applying the framework in different ways to advance digital and health equity. By highlighting multilevel determinants of digital equity that span further than access alone, FITE highlights the complex and differential ways structural determinants restrict or enable digital equity at the individual and community level. As such, achieving digital equity will require strategies designed to not only support individual behavior but also change the broader context to ensure all patients and communities have the choice, opportunity, and resources to use telehealth across the cancer care continuum.
Unusual presentation of metastatic melanoma
Authors: La Anthony , Asarian Armand , Xiao Philip 
Published: June 2024

Abstract
Urinary bladder with concurrent colonic melanoma is an exceptionally uncommon occurrence, posing a diagnostic challenge for clinicians. While rare, it warrants consideration as a potential differential diagnosis, particularly in patients without a history of melanoma who present with persistent hematuria due to its aggressive nature. We present a case of a 55-year-old female with malignant melanoma involving the colon and urinary bladder presenting with hematuria. Given the scarcity of cases and variability in clinical management approaches, there is a pressing need for research efforts to establish standardized protocols and conduct trials to guide clinical practice in this rare entity.
Spindle cell sarcoma of the chest wall: a pediatric case report
Authors: Akbari Masoud , Alter Avram , Kuenzler Keith A 
Published: June 2024

Abstract
Chest wall sarcomas are reported to be infrequent among thoracic tumors. The spindle cell subtype makes up a small percentage of this group. These tumors can be asymptomatic or cause symptoms of chest pain and shortness of breath due to the mass effect, which can lead to a delay in diagnosis. A 10-year-old female with a persistent cough, shortness of breath on exertion, and left-sided chest pain presented to the ED. Imaging indicated a chest wall mass filling the left hemithorax with a rightward mediastinal shift. During surgical resection, two tumors were removed, with resection of parts of the latissimus dorsi and serratus anterior. A diagnosis of MGA:NUTM1 spindle cell sarcoma was made pathologically. The patient was successfully treated with surgery and adjuvant chemoradiotherapy. We hope to add to our academic knowledge by presenting the presentation and treatment of SCS in a pediatric patient.
Cold hardiness-informed budbreak reveals role of freezing temperatures and daily fluctuation in a chill accumulation model
Authors: North Michael G , Workmaster Beth Ann , Atucha Amaya , Kovaleski Al P 
Published: June 2024

Abstract
Fundamental questions in bud dormancy remain, including what temperatures fulfill dormancy requirements (i.e. chill accumulation). Recent studies demonstrate freezing temperatures promote chill accumulation and cold hardiness influences time to budbreak—the phenotype used for dormancy evaluations. Here we evaluated bud cold hardiness and budbreak responses of grapevines (Vitis hybrids) throughout chill accumulation under three treatments: constant (5 °C), fluctuating (−3.5 to 6.5 °C daily), and field conditions (Madison, WI, USA). Chill treatments experiencing lower temperatures promoted greater gains in cold hardiness (field&gt;fluctuating&gt;constant). All treatments decreased observed time to budbreak with increased chill accumulation. However, perceived treatment effectiveness changed when time to budbreak was adjusted to remove cold acclimation effects. Among three classic chill models (North Carolina, Utah, and Dynamic), none was able to correctly describe adjusted time to budbreak responses to chill accumulation. Thus, a new model is proposed that expands the range of chill accumulation temperatures to include freezing temperatures and enhances chill accumulation under fluctuating temperature conditions. Most importantly, our analysis demonstrates that adjustments for uneven acclimation change the perceived effectiveness of chill treatments. Therefore, future work in bud dormancy would benefit from simultaneously evaluating cold hardiness.
Statement of Purpose
Authors: Calderoni Francesco 
Published: June 2024

Abstract
This chapter highlights Article 1, which covers the purpose of the United Nations Convention against Transnational Organized Crime (UNTOC) in an effort to promote cooperation to prevent and combat transnational organized crime more effectively. While the UNTOC lacks a preamble that can support devising the correct interpretation of the text, the General Assembly Resolution adopted the Convention containing statements amenable to a preamble. The chapter note show Article 1 introduces the subsequent articles of UNTOC. Meanwhile, the inspiration for Article 1 comes from the Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances and the 1988 Drug Trafficking Convention. The article explains how the provision is quite self-explanatory and does not leave much room for interpretation.
Measures to Combat Money-Laundering
Authors: Calderoni Francesco 
Published: June 2024

Abstract
This chapter explores several measures to prevent money laundering indicated in Article 7 of United Nations Convention against Transnational Organized Crime (UNTOC). The Article’s main obligations is the establishment of a comprehensive regulatory and supervisory regime for financial institutions and other bodies. Additionally, Article 7 comprises both obligations and optional measures for State Parties. Most of the measures were inspired by the anti-money laundering regime developed by several international institutions and bodies and most often through soft-law instruments such as the Financial Action Task Force (FAFT) Recommendations. Article 7’s wording and scope allow State Parties substantial flexibility in the implementation of the measures.
Criminalization of Corruption
Authors: Calderoni Francesco 
Published: June 2024

Abstract
This chapter considers Article 8, which looks into the criminalization of active and passive bribery that allows States Parties to criminalize additional corrupt practices. The aforementioned corrupt practices include the corruption of foreign public officials and officials of international organizations. Corruption was included in the United Nations Convention against Transnational Organized Crime (UNTOC) due to an increasing international focus on corruption driven by the adoption of other international agreements and United Nations activities. The provision is largely inspired by previous international agreements on corruption and its main elements are consistent with pre-existing provisions. The inspiration for Article 8 comes from several pre-existing international or continental European treaties on corruption that criminalize active and passive bribery and define public officials.
Measures against Corruption
Authors: Calderoni Francesco 
Published: June 2024

Abstract
This chapter explains how Article 9 covers a variety of measures complementing the criminalization provisions of Article 8. It clarifies that the provision has no specific origin in previous international treaties and the early drafts of the Convention did not include specific provisions on corruption. However, the provision lacks any binding requirement, which allows States Parties to determine which measures may achieve the goals. The increasing focus of the United Nations Convention against Transnational Organized Crime (UNTOC) on corruption prompted suggestions to split criminalization and preventive measures into separate provisions. Article 9 ensures effective action by its authorities in the prevention, detection and punishment of the corruption of public officials.
Disposal of Confiscated Proceeds of Crime or Property
Authors: Mancuso Enrico Maria 
Published: June 2024

Abstract
This chapter examines the final stage of the confiscation process indicated in Article 14 of the United Nations Convention against Transnational Organized Crime (UNTOC). The final stage consists of the disposal of seized property and assets and the potential repatriation of these assets to the requesting State. The chapter details the history of negotiations behind Article 14, referencing the 1988 Drug Trafficking Convention and the Ad Hoc Committee. Article 14 follows the disposal of assets confiscated according to Articles 12–13 of UNTOC and is governed by domestic law and administrative procedures of the State in which property is confiscated. The chapter also considers the special consideration of asset sharing.
Extradition
Authors: Schloenhardt Andreas 
Published: June 2024

Abstract
This chapter discusses the concept of extradition as indicated in Article 16 of the United Nations Convention against Transnational Organized Crime (UNTOC). Extradition refers to a formal process to return or deliver fugitives from the jurisdiction where they are present to the jurisdiction with concerning criminal activities. Moreover, extradition is usually based on a treaty and in the absence of relevant treaty provisions there is no obligation under international law to extradite to another State. Article 16 only provides a broad legal framework, rather than spelling out all the requirements and conditions of extradition. The chapter explains the approaches to using UNTOC as the legal basis for extradition.
Measures to Enhance Cooperation with Law Enforcement Authorities
Authors: Taylor Matthew R 
Published: June 2024

Abstract
This chapter explores Article 26 of the United Nations Convention against Transnational Organized Crime (UNTOC). It cites the role that informants can play in facilitating the investigation and prosecution of organized crime and proposes measures designed to encourage cooperation. Since informants face significant risks in providing information to law enforcement, many countries offer an exchange for information, which varies from monetary to anonymity. Article 26 recognizes the value of informants and contemplates various measures subject to domestic laws in an effort to encourage the receipt of evidence by informants. The chapter mentions the use of information as the best means for collecting useful evidence in the fight against organized crime.
Collection, Exchange and Analysis of Information on the Nature of Organized Crime
Authors: Taylor Matthew R 
Published: June 2024

Abstract
This chapter looks into Article 28 of the United Nations Convention against Transnational Organized Crime (UNTOC). It explains the critical importance of having accurate, relevant, comprehensive, and contemporary data on organized crime. Moreover, Article 28 supplements Protocols that recognize and specifically provide a role for civil society as part of broader efforts to combat transnational organized crime. Thus, the provision promotes regional and international cooperation on research and data collection that is consistent with the Convention's overall objectives. The chapter also notes the significance of the evaluation and assessment of anti-crime policies in justifying continued support for such policies either at the domestic level or the international level.
Prevention
Authors: Schloenhardt Andreas , Lelliott Joseph 
Published: June 2024

Abstract
This chapter tackles the preventive measures indicated in Article 31 of the United Nations Convention against Transnational Organized Crime (UNTOC). The deterrent function of criminal justice responses is now widely recognized that effective crime prevention goes far beyond this and requires holistic responses and cooperation. Article 31 particularly asks States parties to endeavour in developing and evaluating projects and best practices to prevent transnational organized crime. The chapter mentions Article 31 has been subject to little technical or scholarly analysis due to its framing with non-mandatory language. It also notes the provision’s sufficient flexibility to account for developments in prevention goals and strategies.
Conference of the Parties
Authors: Schloenhardt Andreas 
Published: June 2024

Abstract
This chapter explains the notion of the Conference of the Parties (CoP) as per Article 32 of the United Nations Convention against Transnational Organized Crime (UNTOC). It notes the establishment of CoP as the institutional body to facilitate and review the implementation of UNTOC by States Parties. The COP aims to improve the capacity of States Parties to combat transnational organized crime and to promote and review the implementation of UNTOC. Moreover, Article 32 provides the basis for the UNTOC Review Mechanism that was launched in 2020. The chapter explains how the CoP must agree upon a mechanism for achieving objectives in line with the Convention.
Implementation of the Convention
Authors: Schloenhardt Andreas 
Published: June 2024

Abstract
This chapter expounds on Article 34 of the United Nations Convention against Transnational Organized Crime (UNTOC). The provision provides States Parties with some guidance and great flexibility for the implementation of the Convention obligations. States Parties are required to ensure the accurate implementation of obligations through domestic laws and administrative measures. The chapter mentions how Article 34(2) secures that domestic offences are not limited to instances involving organized criminal groups and transnational cases. It notes how the provision also ensures the prevention of adopting new laws and administrative measures that are practically inoperative because they failed to comply with constitutional or fundamental legal principles.