bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Gynecologic Laparoscopic Surgery: Experience of Center of Fertility and Reproductive Medicine at St. Paul’s Hospital Millennium Medical College
Authors: Kasa Ayallew , Abdella Mustefa 
Published: July 2024

Background: Recent data suggests that up to 80% of gynecologic surgeries can be accomplished laparoscopically. However, laparoscopy does not come without risks – specifically risks of injury to the bowel, urinary tract, and vasculature. This study assesses the indications for, as well as the complications and outcomes of laparoscopic surgery at the Center of Fertility and Reproductive Medicine at St Paul’s Hospital Millennium Medical College.
Methods and Materials: This is a cross sectional retrospective study using data abstracted from medical records between April 2019 to September 2020. We included all gynecologic laparoscopies done during this date range. The data was collected with Open Data Kit (ODK) software and then transferred to Microsoft Excel for analysis. We set statistical significance at P <0.05.
Results: There were 135 gynecologic surgeries performed, with a mean patient age of 32.4 years. About two-thirds of them presented with primary infertility, and 30% had a previous laparotomy or laparoscopy. Twenty percent had previously been diagnosed with tuberculosis. The main indication for laparoscopy was hydrosalpinx which accounted for 51.1% of surgeries. For patients who underwent surgery for a diagnosis of hydrosalpinx, the majority (54%) underwent bilateral salpingectomy. Our complication rate was 3.7% and rate of conversion to laparotomy was 5.2%.
Conclusion: Our complication rate was higher than previously published laparoscopic complication rates from Asia and Europe. The majority of our complications were bladder and bowel injuries. Complications were managed predominately by conversion to laparotomy.
Keywords: gynecology, laparoscopy, complications, Saint Paul’s Hospital Millennium Medical College.
The Significance of Three Dimensional Soft Tissue Markers in Estimating Fetal Weight Among Iraqi women; A Cross-Sectional Study
Authors: Nori Wassan , Hameed Humadi Esraa , Akram Nabeeha N. 
Published: July 2024

Background Estimating fetal weight (EFW) is essential for safeguarding laboring mothers and newborns. Higher birth weight is associated with poor delivery outcomes; earlier detection is crucial to improve the outcome. Current use of a two-dimensional ultrasonic shows limitations, especially among higher birth weight and those in the late third trimester. We aimed to examine whether the fractional thigh volume (FTV), a three-dimensional ultrasonic parameter, can predict fetal birth weight at 38-42 weeks.
Methods A cross-sectional study recruited 80 pregnant women who fulfilled the criteria; at University Hospital from June 2018 for 14 months. Patients were referred cases for labor induction. Women were assessed by clinical and obstetrical examination. A three-dimensional ultrasound evaluated FTV at the labor ward; 24-48 hours before delivery. Maternal demographics, an indication of admission, and outcomes were recorded. After delivery, the infants' actual birth weight was recorded.
Results The actual birth weight versus EFW by FTV was 3438.01 ±693.04 vs. 3548.47±706.71 grams. A third-degree polynomial equation highlighted the correlation between the EFW by FTV versus actual birth weight. ANOVA tested the equation accuracy, as F-ratio was 299.58, P value< 0.0001. The concordance correlation coefficient was 0.95.
Conclusion, the strong correlations of FTV in predicting fetal weight with a substantial concordance agreement, besides its simplicity and rapid examination time, especially when incorporated into commercial software, makes FTV a recommended marker for predicting EFW.
Prevalence and Determinants of Unintended Pregnancy Among Mothers Delivered in Tertiary and General hospitals, Tigray Region, Ethiopia
Authors: Ataklti Shiferaw  , Amanuel Gessessew  , Girmatsion Fisseha  , Hale Teka  , Sumeya Ahmed  , Jessica Morgan  , Gelila Goba  , Yemane Awol 
Published: July 2024

Background: Unintended pregnancy represents an important public health challenge in many countries, especially in the developing world. Numerous prevention strategies have been employed worldwide in an effort to address this problem. Unintended pregnancies contribute significantly to adverse health, social and economic outcomes and increase the risks of maternal death as well as neonatal, infant and child mortality. At present, standardized efforts to reduce the incidence of unintended pregnancy are sparse.

Objective: This study aimed to assess prevalence and determinants unintended pregnancy among mothers delivered in Ayder Comprehensive Specialized Hospital and Mekelle hospital.

Methods: A facility based cross-sectional study was conducted over a period of two months (January 1, 2018 to February 30, 2018). The study was conducted in among 614 postpartum mothers across two hospital sites during the aforementioned time period. Bivariate logistic regression was used to assess for association between the independent variables and unintended pregnancy. Statistical significance was determined as P < 0.05.

Results: A totals of 614 mothers participated in the study. The prevalence of unintended pregnancy was 42.8%. Mistimed pregnancy accounting for 33.7 % and unwanted pregnancy accounting for 9.1%. About 88 % of mistimed pregnancies were due to contraception not used and 12% are due to contraception failure. Lower level of education, interpregnancy interval of 6 months to 5 years, older maternal age, and larger family size were factors significantly associated with unintended pregnancy.
Conclusions: Nearly half of women had an unintended pregnancy, a rate higher than previously reported. Lower level of education, older maternal age, and larger family were factors significantly associated with unintended pregnancy. The high prevalence of unintended pregnancies in Mekelle highlights the need for implementation strategies that encourage education of women, creating awareness on family planning and child spacing.
COJOINED TWINS: SAFE TERMINATION OF PREGNANCY THROUGH DILATION AND EVACUATION AT LATER GESTATION: A CASE SERIES
Authors: Fessehaye Abraham , Diress Tesfaye , Bekele Delayehu , Belay Lemi 
Published: July 2024

Abstract
Background: Currently, there is limited evidence on termination of pregnancy for cojoined twin documented with only 33 cases reports to-date. This study aimed to describe the clinical and procedure characteristics of second trimester dilation and evacuation(D&E) for cojoined twins at later gestation.
Methods: This retrospective case series was conducted at a tertiary-level hospital in Ethiopia from February 2023- July 2023. Women who had a cojoined twin pregnancy in later gestation (?20 weeks) and underwent second trimester D&E were retrospectively studied through chart review. Clinical presentation, D&E procedural description, and procedure outcomes of the cases were analyzed.
Results: Three women who had a cojoined twin in later gestation (?20 weeks) and underwent second trimester D&E were identified. In two of the cases, a two- day cervical preparation with laminaria was used to prepare the cervix while overnight Foley catheter (1-day preparation) was used for similar purpose in the third case. A cervical dilation of 3 cm was achieved in all cases and was deemed adequate to proceed with the procedure by the managing physicians. Intra-operative ultrasound guidance was utilized in all the cases and there were no complications encountered.
Conclusion: Our case series underscores the importance of achieving adequate cervical preparation, utilization of intra-operative ultrasound guidance, and handling the procedure by the most experienced provider, in increasing the safety and effectiveness of D&E procedures for conjoined twin at later gestation.
Keywords: cojoined twin, dilation and evacuation, D&E for conjoined twin, D&E for twin
Comparison of selective laser melting and stereolithography etching templates for guided endodontics
Authors: Zhang Ting , Chen Du , Zhang Fei , Xie Sijing , Wu Guofeng , Hu Qingang , Yan Fuhua , Tang Xuna 
Published: July 2024

Background
With the increasing application of guided endodontics to treat complex root canal treatment, the entire process of root canal treatment has become more precise, reducing damage to tooth structure and improving success rates. However, due to the limitations of the operating space, the use of guided endodontic templates in posterior root canal treatment is less common. This study aims to compare the accuracy and reliability of selective laser melting (SLM) and traditional stereolithography etching (SLA) guided endodontic templates for posterior root canals, providing better treatment strategies for posterior root canal treatment.

Methods
The teeth were randomly assigned to either SLM or SLA group. Preoperative cone-beam computed tomography (CBCT) and a three-dimensional (3D) scanner were used to establish the 3D root canal system and the accurate occlusal models of the teeth. The virtual access to the canal access was designed using Mimics 19.0 and 3-Matic 11.0. The endodontic access was performed based on either SLM or SLA templates. The accuracy of endodontic preparation was measured in three-dimensions by calculating deviations from planned accesses. The template height and tooth substance loss rates in each group were measured.

Results
SLM-guided templates have a low average deviation at the entry point and apical portion of the bur of total posterior teeth (including premolars and molars) and individual molars (P < 0.05). Moreover, there was a significant difference in angular deviations and height of template in total posterior teeth and individual molars (P < 0.05). The mean substance loss rate of the SLA group was slightly greater than that of the SLM group, but the difference was not statistically (P > 0.05).

Conclusions
SLM-guided endodontics provides a more predictable and precise location of root canal orifice for the treatment of posterior teeth.
Machine learning and bioinformatics analysis of diagnostic biomarkers associated with the occurrence and development of lung adenocarcinoma
Authors: Li Yong , Cai Yunxiang , Ji Longfei , Wang Binyu , Shi Danfei , Li Xinmin 
Published: July 2024

Objective
Lung adenocarcinoma poses a major global health challenge and is a leading cause of cancer-related deaths worldwide. This study is a review of three molecular biomarkers screened by machine learning that are not only important in the occurrence and progression of lung adenocarcinoma but also have the potential to serve as biomarkers for clinical diagnosis, prognosis evaluation and treatment guidance.

Methods
Differentially expressed genes (DEGs) were identified using comprehensive GSE1987 and GSE18842 gene expression databases. A comprehensive bioinformatics analysis of these DEGs was conducted to explore enriched functions and pathways, relative expression levels, and interaction networks. Random Forest and LASSO regression analysis techniques were used to identify the three most significant target genes. The TCGA database and quantitative polymerase chain reaction (qPCR) experiments were used to verify the expression levels and receiver operating characteristic (ROC) curves of these three target genes. Furthermore, immune invasiveness, pan-cancer, and mRNA-miRNA interaction network analyses were performed.

Results
Eighty-nine genes showed increased expression and 190 genes showed decreased expression. Notably, the upregulated DEGs were predominantly associated with organelle fission and nuclear division, whereas the downregulated DEGs were mainly associated with genitourinary system development and cell-substrate adhesion. The construction of the DEG protein-protein interaction network revealed 32 and 19 hub genes with the highest moderate values among the upregulated and downregulated genes, respectively. Using random forest and LASSO regression analyses, the hub genes were employed to identify three most significant target genes.TCGA database and qPCR experiments were used to verify the expression levels and ROC curves of these three target genes, and immunoinvasive analysis, pan-cancer analysis and mRNA-miRNA interaction network analysis were performed.

Conclusion
Three target genes identified by machine learning: BUB1B, CENPF, and PLK1 play key roles in LUAD development of lung adenocarcinoma.
Deep long‐period earthquakes west of the volcanic arc in Oregon: Evidence of serpentine dehydration in the fore‐arc mantle wedge
Authors: Vidale J. E. , Schmidt D. A. , Malone S. D. , Hotovec‐Ellis A. J. , Moran S. C. , Creager K. C. , Houston H. 
Published: January 2014

AbstractHere we report on deep long‐period earthquakes (DLPs) newly observed in four places in western Oregon. The DLPs are noteworthy for their location within the subduction fore arc: 40–80 km west of the volcanic arc, well above the slab, and near the Moho. These “offset DLPs” occur near the top of the inferred stagnant mantle wedge, which is likely to be serpentinized and cold. The lack of fore‐arc DLPs elsewhere along the arc suggests that localized heating may be dehydrating the serpentinized mantle wedge at these latitudes and causing DLPs by dehydration embrittlement. Higher heat flow in this region could be introduced by anomalously hot mantle, associated with the western migration of volcanism across the High Lava Plains of eastern Oregon, entrained in the corner flow proximal to the mantle wedge. Alternatively, fluids rising from the subducting slab through the mantle wedge may be the source of offset DLPs. As far as we know, these are among the first DLPs to be observed in the fore arc of a subduction‐zone system.
Orographic effects on snow deposition patterns in mountainous terrain
Authors: Mott R. , Scipión D. , Schneebeli M. , Dawes N. , Berne A. , Lehning M. 
Published: January 2014

AbstractOrographic lifting of air masses and other topographically modified flows induce cloud and precipitation formation at larger scales and preferential deposition of precipitation at smaller scales. In this study, we examine orographic effects on small‐scale snowfall patterns in Alpine terrain. A polarimetric X‐band radar was deployed in the area of Davos (Switzerland) to determine the spatial variability of precipitation. In order to relate measured precipitation fields to flow dynamics, we model flow fields with the atmospheric prediction model “Advanced Regional Prediction System.” Additionally, we compare radar reflectivity fields with snow accumulation at the surface as modeled by Alpine3D. We investigate the small‐scale precipitation dynamics for one heavy snowfall event in March 2011 at a high resolution of 75 m. The analysis of the vertical and horizontal distribution of radar reflectivity at horizontal polarization and differential reflectivity shows polarimetric signatures of orographic snowfall enhancement near the summit region. Increasing radar reflectivity at horizontal polarization over the windward slopes toward the crest and downwind decreasing reflectivity over the leeward slopes is observed. The temporal variation of the location of maximum concentration of snow particles is partly attributed to the effect of preferential deposition of snowfall: For situations with strong horizontal winds, the concentration maximum is shifted from the ridge crest toward the leeward slopes. Qualitatively, we discuss the relative role of cloud microphysics such as the seeder‐feeder mechanism versus atmospheric particle transport in generating the observed snow deposition at the ground.
Local partitioning of the overturning circulation in the tropics and the connection to the Hadley and Walker circulations
Authors: Schwendike Juliane , Govekar Pallavi , Reeder Michael J. , Wardle Richard , Berry Gareth J. , Jakob Christian 
Published: January 2014

AbstractConceptually, it is useful to partition the three‐dimensional tropical circulation into meridional and zonal components, namely, the Hadley and Walker circulations. The averaging involved in their definitions can introduce ambiguities. These problems can be circumvented by first partitioning the total vertical mass flux into components associated with overturning in the meridional and zonal directions, respectively, called here the local Hadley and local Walker circulations. Defining the local Hadley and local Walker circulations this way ensures the pair of two‐dimensional overturning circulations can be added to give the original three‐dimensional circulation, even when the averages are taken over limited domains. The method is applied to the vertical motion from the ERA‐Interim reanalysis for the period 1979 to 2009. One important result is that the local Hadley circulation responds much more strongly to ENSO than the local Walker circulation, even though the local Walker circulation in the central Pacific weakens during El Niño years and strengthens and widens during La Niña years.
Burnout and the Fine‐Tuning of Cognitive Resources
Authors: Kleinsorge Thomas , Diestel Stefan , Scheil Juliane , Niven Karen 
Published: January 2014

SummaryWe examined the performance in a constant foreperiod task in two samples screened for either high or low scores on the core burnout dimension emotional exhaustion. In line with our expectations, participants scoring high on emotional exhaustion exhibited a specific deficit with respect to maintaining a high level of response readiness at longer foreperiods. This demonstration of a modulation of constant foreperiod performance by burnout adds to the growing body of evidence suggesting that exhaustion is related to deficits in basic cognitive mechanisms underlying the fine‐tuning of cognitive resources according to task demands. Copyright © 2014 John Wiley & Sons, Ltd.
Robust stochastic convergence and stability of neutral‐type neural networks with Markovian jump and mixed delays
Authors: Zheng Cheng‐De , Lv Xixi , Liang Wenlong , Wang Zhanshan 
Published: January 2014

SummaryThe robust stochastic convergence and stability in mean square are investigated for a class of uncertain neutral‐type neural networks with both Markovian jump parameters and mixed delays. First, by employing the Lyapunov method and a generalized Halanay‐type inequality for stochastic differential equations, a delay‐dependent condition is derived to guarantee the state variables of the discussed neural networks to be globally uniformly exponentially stochastic convergent to a ball in the state space with a prespecified convergence rate. Next, by applying the Jensen integral inequality and a novel reciprocal convex lemma, a delay‐dependent criterion is developed to achieve the globally robust stochastic stability in mean square. With some parameters being fixed in advance, the proposed conditions are all expressed in terms of LMIs, which can be solved numerically by employing the standard MATLAB LMI toolbox package. Finally, two illustrated examples are given to show the effectiveness and less conservatism of the obtained results over some existing works. Copyright © 2014 John Wiley & Sons, Ltd.
Definition of a model based on bibliometric indicators for assessing applicants to academic positions
Authors: Vieira Elizabeth S. , Cabral José A.S. , Gomes José A.N.F. 
Published: January 2014

A model based on a set of bibliometric indicators is proposed for the prediction of the ranking of applicants to an academic position as produced by a committee of peers. The results show that a very small number of indicators may lead to a robust prediction of about 75% of the cases.We start with 12 indicators to build a few composite indicators by factor analysis. Following a discrete choice model, we arrive at 3 comparatively good predicative models. We conclude that these models have a surprisingly good predictive power and may help peers in their selection process.
Scaffold/matrix attachment regions from CHO cell chromosome enhanced the stable transfection efficiency and the expression of transgene in CHO cells
Authors: Chang Ming , Liu Ruijie , Jin Qingzhe , Liu Yuanfa , Wang Xingguo 
Published: January 2014

AbstractTwo scaffold/matrix attachment regions (S/MARs) from Chinese hamster ovary (CHO) cell chromosomes were identified computationally and cloned as the domain boundaries regions. As partition chromosomes in independently regulated units to increase the exogenous gene expression, these two S/MARs (MAR1 and MAR6) flanked expression vectors were respectively transfected into CHO cells. The results showed that MAR1 and MAR6 were much more potent to increase the stable transfection efficiency than the chicken lysozyme gene 5′ S/MARs, which had been experimentally identified to increasing the expression of heterologous gene. Moreover, MAR6 is more active in mediating high and consistent gene expression in CHO cells than the chicken lysozyme gene 5′ S/MARs.
Purification and characterization of a novel lichenase from Bacillus licheniformis GZ‐2
Authors: Gao Zhen 
Published: January 2014

AbstractA novel lichenase from Bacillus licheniformis GZ‐2 was purified to homogeneity by two steps ion‐exchange chromatography with a specific activity of 8231.3 U/mg. The purified enzyme showed as a single protein band with a molecular mass of 25 kDa. The optimum pH and temperature for the enzyme activity were 6.5 and 60 °C, respectively. The enzyme exhibited strict specificity for ‐1,3–1,4‐d‐glucans. The kinetic parameters Km and Vmax were 5.11 mg/mL and 2097 µmol/Min/mg for lichenan and 7.42 mg/mL and 1440 µmol/Min/mg for barley ‐glucan. Compared to most of the reported ‐1,3–1,4‐glucanases (lichenase), the activity of the purified enzyme for lichenan was much higher than that for barley ‐glucan. The main products of ‐glucan hydrolyzed by the lichenase were cellubiosyltriose (DP3) and cellutriosyltraose (DP4). The lichenase gene from B. licheniformis GZ‐2 was cloned and sequenced. The open reading frame of gene gz‐2 contained 642 bp coding for a 214 amino acid mature protein. The gene was cloned into an expression vector pET 28a and expressed in Escherichia coli BL21. The activity in cell lysate supernatant was 137.9 U/mg.
Does the type of first‐line regimens influence the receipt of second‐line chemotherapy treatment? An analysis of 3211 metastatic colon cancer patients
Authors: Zheng Zhiyuan , Hanna Nader , Onukwugha Eberechukwu , Reese Emily S. , Seal Brian , Mullins C. Daniel 
Published: January 2014

AbstractWith new agents entering the market, the sequencing of first‐line (Tx1), second‐line (Tx2), and subsequent chemotherapy/biologics regimens are being examined. We examined how Tx1 regimens impacted the likelihood of receiving Tx2 among metastatic colon cancer (mCC) patients. Surveillance, Epidemiology and End Results (SEER)‐Medicare data were used to identify elderly mCC patients between 2003 and 2007. The inverse probability weighting Cox regression method was utilized to study the relationship between receipt of Tx2 and Tx1 regimens, controlling for patient‐level factors. Of the 7895 elderly patients identified, 3211 (41%) received Tx1 of which 1440 proceeded to Tx2. The impact of Tx1 on receipt of Tx2 varied by the specific regimens utilized. As compared to 5FU/LV users, IROX (Hazard Ratio [HR] = 0.03; P < 0.01) and IROX + Biologics (HR = 0.20; P < 0.01) users were less likely to receive Tx2; (oxaliplatin) OX + Biologics (HR = 1.26; P < 0.01) users were more likely to receive Tx2. Significant patient‐level factors included: Hispanic ethnicity (HR = 0.67; P < 0.01); being married (HR = 0.87; P = 0.01); proxy for poor performance status (HR = 0.82; P = 0.05); each 10‐year age increment (HR = 1.14; P < 0.01); and State buy‐in status (HR = 1.21; P = 0.01). The specific first‐line regimen does impact mCC patients' likelihood of receiving Tx2 in clinical practice. Elderly mCC patients, their health care providers, and policy makers will benefit from new evidence about the impact of sequencing of treatment lines.