bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non‐coding RNA‐mediated modulation of endoplasmic reticulum stress under pathological conditions
Authors: Çiftçi Yusuf Cem , Yurtsever Yiğit , Akgül Bünyamin 
Published: July 2024

AbstractEndoplasmic reticulum (ER) stress, which ensues from an overwhelming protein folding capacity, activates the unfolded protein response (UPR) in an effort to restore cellular homeostasis. As ER stress is associated with numerous diseases, it is highly important to delineate the molecular mechanisms governing the ER stress to gain insight into the disease pathology. Long non‐coding RNAs, transcripts with a length of over 200 nucleotides that do not code for proteins, interact with proteins and nucleic acids, fine‐tuning the UPR to restore ER homeostasis via various modes of actions. Dysregulation of specific lncRNAs is implicated in the progression of ER stress‐related diseases, presenting these molecules as promising therapeutic targets. The comprehensive analysis underscores the importance of understanding the nuanced interplay between lncRNAs and ER stress for insights into disease mechanisms. Overall, this review consolidates current knowledge, identifies research gaps and offers a roadmap for future investigations into the multifaceted roles of lncRNAs in ER stress and associated diseases to shed light on their pivotal roles in the pathogenesis of related diseases.
Framing the allopathic approach to health and disease labels through patient narratives during the COVID‐19 pandemic first wave in Ecuador: An understudied and underutilized tool in health care practice and delivery
Authors: Saleh Marwa 
Published: July 2024

AbstractPresented in this article is a search for folk, popular, and professional health care labels through patient narratives. Fieldwork was done in the Ecuadorian communities of Santa Rosa and Pano during the first wave of COVID‐19. The results emphasize the utility of studying labels to better understand what communities experience in health crises, the opportunities to improve allopathic health care delivery and engagement with the folk and popular sectors. Both communities had adapted labels that were familiar to them from prior health experiences and served to inform their personal medical care during the pandemic. Meanwhile, in Pano, an Indigenous predominant community, people had inherited labels for plants and pandemics in both the Kichwa and Spanish language, and those provided a vocabulary of hope to the people. In Santa Rosa the labels demonstrated the grief and difficult times the community had experienced with the limited health resources available.
Spoken word choreographies in additional language learning practices in upper secondary school: Entanglements between languaging‐and‐dancing
Authors: Jusslin Sofia , Kaarla Lotta , Korpinen Kaisa , Lilja Niina 
Published: July 2024

AbstractThere are calls for developing ways to teach language that can inspire and motivate students to study additional languages. While previous research has pointed toward benefits of arts‐based activities in language learning, combining language and dance has mainly been studied with younger language learners. Contextualized within the course “Dance with language,” this study explores spoken word choreographies—word‐ and movement‐based choreographies—that combine dance and the learning of Swedish as an additional language at a Finnish upper secondary school. The study engages with new materialist theories to understand languaging as an activity and relational, embodied, and material processes. Using diffractive analysis with comics‐based research strategies, the analysis suggests that languaging‐and‐dancing become entangled through four doings: exploring, re‐working, co‐creating, and negotiating‐and‐switching. The spoken word choreographies offer a potentially valuable way to teach language in their move beyond students’ potential restrictions of vocabulary, structure, and grammar in the language to emphasize playfulness and creative explorations as part of language‐learning processes. In conclusion, the study proposes that dancing and spoken word, and the combination thereof, bring specific qualities to creating smooth languaging spaces that embrace wild, playful, creative, and unpredictable forces and movements in language‐learning practices.
Subversive mythical figures and feminist resistance: On the rise of posthuman ‘professionals’
Authors: Turcotte Pier‐Luc , Holmes Dave , Johansson Jim , Saïd‐Gagné Sagal , Perron Amélie 
Published: July 2024

AbstractWithin the context of neoliberal healthcare, nurses and other health professionals face working conditions that leave them perpetually feeling inadequate, as though they are not enough. They are consistently expected to achieve more with less resources. In such an environment, mere professionalism proves wholly insufficient, enforcing norms of altruism and kindness. Professionals must transcend this disciplinary tool and embody a ‘more‐than‐professional’ approach. This study, informed by critical posthumanism, employs three mythical archetypes—the Medusa, the Witch and the Siren—to illuminate potential avenues for resistance against prevailing trends in healthcare. Drawing on the perspectives of Hélène Cixous, Silvia Federici and Jacques Rancière, we introduce a process of resistance for healthcare professionals pushing back against the challenges of crumbling healthcare systems. Cixous' feminist reimagining of Medusa symbolizes intensified embodied sensory experiences, emphasizing the power of irony, laughter and writing in highlighting the daily struggles faced by healthcare workers. Federici's depiction of the Witch exposes clandestine alliances among healthcare workers and patients, akin to a pact with the devil, countering the individualistic, alienating approach to care provision and resisting neoliberal pressures. The Witch archetype embodies resistance grounded in creativity against the commodification of public healthcare. Finally, Rancière's ‘politics of the Siren' offers a strategy for disrupting entrenched hierarchies from the underworld. Like Sirens, healthcare workers and patients can subversively transform their silence into songs of resistance, simultaneously operating from beneath the surface of accountability measures. Our intention is to showcase the emergence of posthuman ‘professionals’ who adapt by forging new modes of social relations in response to neoliberal constraints, straying from conventional, apolitical notions of ‘professionalism’. Drawing lessons from mythical figures of resistance offers a fresh understanding of subversion as a catalyst for social and political transformation within the healthcare sector.
Modulation of external and internal aluminum resistance by ALS3‐dependent STAR1‐mediated promotion of STOP1 degradation
Authors: Fan Ni , Li Xinbo , Xie Wenxiang , Wei Xiang , Fang Qiu , Xu Jingyi , Huang Chao‐Feng 
Published: July 2024

Summary

The ALMT1 transporter aids malate secretion, chelating Al3+ ions to form nontoxic Al–malate complexes, believed to exclude Al from the roots. However, the extent to which malate secreted by ALMT1 is solely used for the exclusion of Al3+ or can be reutilized by plant roots for internal Al tolerance remains uncertain.

In our investigation, we explored the impact of malate secretion on both external and internal Al resistance in Arabidopsis thaliana. Additionally, we delved into the mechanism by which the tonoplast‐localized bacterial‐type ATP‐binding cassette (ABC) transporter complex STAR1/ALS3 promotes the degradation of the Al resistance transcription factor STOP1 to regulate ALMT1 expression.

Our study demonstrates that the level of secreted malate influences whether the Al–malate complex is excluded from the roots or transported into root cells. The nodulin 26‐like intrinsic protein (NIP) subfamily members NIP1;1 and NIP1;2, located in the plasma membrane, coordinate with STAR1/ALS3 to facilitate Al–malate transport from root apoplasm to the symplasm and eventually to the vacuoles for the internal Al detoxification. ALS3‐dependent STAR1 interacts with and promotes the degradation of STOP1, regulating malate exudation.

Our findings demonstrate the dual roles of malate exudation in external Al exclusion and Al absorption for internal Al detoxification.
The single RRM domain‐containing protein SARP1 is required for establishment of the separation zone in Arabidopsis
Authors: Yun Ju , Lee Inhye , Lee Jae Ho , Kim Seonghwan , Jung Su Hyun , Oh Sung Aeong , Lee Jiyoun , Park Soon Ki , Soh Moon‐Soo , Lee Yuree , Kwak June M. 
Published: July 2024

Summary

Abscission is the shedding of plant organs in response to developmental and environmental cues. Abscission involves cell separation between two neighboring cell types, residuum cells (RECs) and secession cells (SECs) in the floral abscission zone (AZ) in Arabidopsis thaliana. However, the regulatory mechanisms behind the spatial determination that governs cell separation are largely unknown.

The class I KNOTTED‐like homeobox (KNOX) transcription factor BREVIPEDICELLUS (BP) negatively regulates AZ cell size and number in Arabidopsis. To identify new players participating in abscission, we performed a genetic screen by activation tagging a weak complementation line of bp‐3. We identified the mutant ebp1 (enhancer of BP1) displaying delayed floral organ abscission.

The ebp1 mutant showed a concaved surface in SECs and abnormally stacked cells on the top of RECs, in contrast to the precisely separated surface in the wild‐type. Molecular and histological analyses revealed that the transcriptional programming during cell differentiation in the AZ is compromised in ebp1. The SECs of ebp1 have acquired REC‐like properties, including cuticle formation and superoxide production.

We show that SEPARATION AFFECTING RNA‐BINDING PROTEIN1 (SARP1) is upregulated in ebp1 and plays a role in the establishment of the cell separation layer during floral organ abscission in Arabidopsis.
Revisiting plant cuticle biophysics
Authors: Heredia Antonio , Benítez José J. , González Moreno Ana , Domínguez Eva 
Published: July 2024

SummaryThe plant cuticle is located at the interface of the plant with the environment, thus acting as a protective barrier against biotic and abiotic external stress factors, and regulating water loss. Additionally, it modulates mechanical stresses derived from internal tissues and also from the environment. Recent advances in the understanding of the hydric, mechanical, thermal, and, to a lower extent, optical and electric properties of the cuticle, as well as their phenomenological connections and relationships are reviewed. An equilibrium based on the interaction among the different biophysical properties is essential to ensure plant growth and development. The notable variability reported in cuticle geometry, surface topography, and microchemistry affects the analysis of some biophysical properties of the cuticle. This review aimed to provide an updated view of the plant cuticle, understood as a modification of the cell wall, in order to establish the state‐of‐the‐art biophysics of the plant cuticle, and to serve as an inspiration for future research in the field.
READRetro: natural product biosynthesis predicting with retrieval‐augmented dual‐view retrosynthesis
Authors: Kim Taein , Lee Seul , Kwak Yejin , Choi Min‐Soo , Park Jeongbin , Hwang Sung Ju , Kim Sang‐Gyu 
Published: July 2024

Summary

Plants, as a sessile organism, produce various secondary metabolites to interact with the environment. These chemicals have fascinated the plant science community because of their ecological significance and notable biological activity. However, predicting the complete biosynthetic pathways from target molecules to metabolic building blocks remains a challenge.

Here, we propose retrieval‐augmented dual‐view retrosynthesis (READRetro) as a practical bio‐retrosynthesis tool to predict the biosynthetic pathways of plant natural products. Conventional bio‐retrosynthesis models have been limited in their ability to predict biosynthetic pathways for natural products. READRetro was optimized for the prediction of complex metabolic pathways by incorporating cutting‐edge deep learning architectures, an ensemble approach, and two retrievers.

Evaluation of single‐ and multi‐step retrosynthesis showed that each component of READRetro significantly improved its ability to predict biosynthetic pathways. READRetro was also able to propose the known pathways of secondary metabolites such as monoterpene indole alkaloids and the unknown pathway of menisdaurilide, demonstrating its applicability to real‐world bio‐retrosynthesis of plant natural products.

For researchers interested in the biosynthesis and production of secondary metabolites, a user‐friendly website (https://readretro.net) and the open‐source code of READRetro have been made available.
Current advances of oral cancer in Taiwan
Authors: Yang Yi‐Hsin 
Published: July 2024

AbstractObjectivesTo provide updated statistics of oral cancer incidence and mortality in Taiwan, and to describe recent developments for oral cancer control to reduce oral cancer incidence and mortality.MethodsThe Taiwan Cancer Registry Annual Report 2023, the Taiwan Cancer Registry Online Interactive Search System, and the 2023 Health Promotion Administration Annual Report are consulted and summarized. A literature search using PubMed was also conducted to identify Taiwan oral cancer control‐related studies.ResultsTaiwan, with a long history of areca/betel quid chewing, has battled with oral cancer for decades. In 2021, the male lip and oral cavity cancer incidence is 29.77 (per 100,000 persons) and mortality is 11.25. Over these years, the male chewing prevalence was reduced to 6.2% in 2018. Taiwan has a sustained national oral cancer screening programme provided to high‐risk groups biennially.ConclusionsAlthough the age‐standardized incidence rates have been slowly decreasing since 2009, due to Taiwan's ageing population, the actual oral cancer burden is still stringent. The collaboration of multi‐ministries and agencies on promoting areca nut and betel quid control, improving oral cancer awareness, and delivering cancer care remains essential to prevent oral cancer and reduce oral cancer deaths.
Estimating the loss‐reduction effects of disaster preparedness and mitigation: An empirical study of US coastal states
Authors: Miao Qing , Davlasheridze Meri 
Published: July 2024

AbstractAs extreme weather events like floods and storms continue to increase, it is crucial to examine the degree to which various disaster preparedness and mitigation investments can lower these risks. In this research, we empirically examine the effects of multiple federal disaster aid programs on reducing subsequent flood‐ and storm‐related damages across US coastal states. Our analysis distinguishes aid programs and their funded projects targeting different emergency management functions, including preparedness, nonstructural and structural mitigation, emergency response and protective measures, and rehabilitation of public infrastructure. We construct panel data of more than 1800 US counties over the years 2000–2019 and estimate a fixed‐effects model with time‐varying county‐level socioeconomic and demographic characteristics. We find that disaster aid generally helps mitigate property damages, although this loss‐reduction effect varies by program. Among all aid programs, the Emergency Management Performance Grant results in the largest reduction of future flood damages. The Public Assistance grants supporting emergency work are also found to exert a strong effect on risk reduction. We also find that the impacts of disaster aid are higher in coastal counties. Our study is one of the first few examining the resilience implication of disaster aid in coastal counties, and our results underscore the importance of investing in capacity building, contingency planning, and consistency in maintenance.
Literary Insanity and Psychiatric Literacy: Youth, Mental Health, and Contemporary Russian Fiction
Authors: Kaminer Jenny 
Published: July 2024

AbstractIn the first post‐Soviet decade, Russian mental health professionals sounded the alarm about a looming psychiatric crisis affecting the nation’s youth. Some twenty years later, a spate of literary works seemingly marked the fictional apotheosis of these anxieties. Although critics have identified and reflected upon the significance of the “insanity cluster” in prose published around 2017, the youth of the protagonists has remained largely unconsidered. This essay focuses on three literary works that emerged at the intersection of two recent turns in contemporary Russian culture: the adolescent and the psychotherapeutic. These works featuring young, psychologically disturbed protagonists emphasize the corporeal aspects of mental illness. The characters strive to overcome the psyche or soul through empirically observable, bodily phenomena, such as violence against themselves and others, or sexual promiscuity. All three works unmask the harmful consequences of externalizing psychic abnormalities, of their teenage heroes’ belief that scarring one’s own body or that of another sentient being can ameliorate the symptoms of schizophrenia or other mental disturbances. With their complex and nuanced literary exploration of the interplay between “consciousness” and “flesh,” the three novels provide a fictional retort to narrowly mechanistic understandings of the psychology and behavior of youth.
Identification of shared immune infiltration characteristic molecules in dermatomyositis and nasopharyngeal carcinoma using bioinformatics
Authors: Kai Jinyan , Huang Haitao , Su Jiaqi , Chen Qiong 
Published: July 2024

AbstractBackgroundDermatomyositis (DM) is a kind of dermatologically associated autoimmune disease that is notably associated with an increased risk of concurrent malignancies, although the underlying mechanisms remain to be fully elucidated. The purpose of this investigation was to examine the immunological parallels between DM and nasopharyngeal carcinoma (NPC), with the aim of identifying pivotal biomarkers that could facilitate a deeper understanding and enhance the predictive capabilities of NPC in DM patients.MethodData for DM and NPC were sourced from the Gene Expression Omnibus (GEO) database. Immune infiltration was analyzed using the “cibersort” R package, differentially expressed genes (DEGs) were identified with the “limma” package, and functional pathways were investigated through Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses. Characteristic genes were determined by Utilizing Protein–Protein Interaction (PPI) and Least Absolute Shrinkage and Selection Operator (LASSO), and their features were validated using the GSE53819 dataset.ResultsIn comparison to normal samples, significant infiltration of macrophage M1 was observed in both DM and NPC. The analysis revealed 77 DEGs in DM and 1051 DEGs in NPC, with 22 genes found to be co‐DEGs. Following PPI and LASSO analysis, six distinctive genes were retained. Notably, CCL8, IFIH1, CXCL10, and CXCL11 exhibited optimal diagnostic efficacy for NPC and displayed significant correlation with macrophage M1 infiltration within the carcinoma.ConclusionFour characteristic genes, CCL8, IFIH1, CXCL10, and CXCL11 are risk factors for both DM and NPC. They exhibit a robust correlation with the incidence of NPC and offer a commendable diagnostic efficacy. Furthermore, they may serve as prospective predictive biomarkers for the emergence of NPC in DM.
Causality of inflammatory bowel disease and seborrheic keratosis: A bidirectional two‐sample Mendelian randomization study
Authors: Lin Zhipeng , Zhang Qi , Miao Yu , Jiang Lin , Wang Aoxue 
Published: July 2024

AbstractBackgroundPrevious studies have revealed a potential link between inflammatory bowel disease (IBD) and seborrheic keratosis (SK). However, whether this association is causal or confounded remains unknown.MethodsWe conducted this two‐sample Mendelian randomization (TSMR) analysis to clarify bidirectional causality between IBD, including its two primary conditions Crohn's disease (CD) and ulcerative colitis (UC), and SK. The summary genetic data of IBD, CD, UC and SK were obtained from accessible genome‐wide association studies (GWAS). This TSMR study was primarily performed using inverse‐variance weighted (IVW) method, complemented by MR‐Egger, weighted median (WM), Bayesian weighted MR (BWMR), MR‐robust adjusted profile score (MR‐RAPS), MR‐pleiotropy residual sum and outlier (MR‐PRESSO), and radial IVW MR analyses with modified second‐order weights (IVW [Mod 2nd]) methods. Assessment of sensitivity and identification of potential outliers were subsequently conducted to aid interpretation of results.ResultsThe forward MR results showed that IBD [odds ratio (OR) = 1.068, 95% confidence interval (CI) = 1.010–1.129, p = 0.020) and its subtype CD (OR = 1.088, 95%CI = 1.038–1.139, p < 0.001) increased the risk of SK. However, the occurrence of SK could not be affected by UC (OR = 1.090, 95%CI = 0.977–1.216, p = 0.123). In the reverse analysis, no causal relationship between SK and IBD (OR = 0.905, 95%CI = 0.813–1.008, p = 0.069), UC (OR = 0.959, 95%CI = 0.860–1.068, p = 0.443), and CD (OR = 0.933, 95%CI = 0.846–1.029, p = 0.165) was identified.ConclusionThese findings demonstrate that IBD and its subtype CD could increase the incidence of SK in European populations, whereas SK does not affect IBD occurrence.