bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lesion analysis for cingulotomy and limbic leucotomy: comparison and correlation with clinical outcomes
Authors: Yang Jimmy C. , Ginat Daniel T. , Dougherty Darin D. , Makris Nikos , Eskandar Emad N. 
Published: November 2013

Object
Cingulotomy and limbic leucotomy are lesioning surgeries with demonstrated benefit for medically intractable psychiatric illnesses. They represent significant refinements of the prefrontal lobotomy used from the 1930s through the 1950s. However, the associations between anatomical characterization of these lesions and outcome data are not well understood. To elucidate these procedures and associations, the authors sought to define and compare the neuroanatomy of cingulotomy and limbic leucotomy and to test a method that uses neuroanatomical data and voxel-based lesion–symptom mapping (VLSM) to reveal potential refinements to modern psychiatric neurosurgical procedures.

Methods
T1-weighted MR images of patients who had undergone cingulotomy and limbic leucotomy were segmented and registered onto the Montreal Neurological Institute T1-weighted template brain MNI152. Using an atlas-based approach, the authors calculated, by case, the percentage of each anatomical structure affected by the lesion. Because of the infrequency of modern lesion procedures and the requirement for higher-resolution clinical imaging, the sample size was small.
The pilot study correlated cingulotomy and limbic leucotomy lesion characteristics with clinical outcomes for patients with obsessive-compulsive disorder. For this study, preoperative and postoperative Yale-Brown Obsessive Compulsive Scale scores for 11 cingulotomy patients and 8 limbic leucotomy patients were obtained, and lesion masks were defined and compared anatomically by using an atlas-based method. Statistically significant voxels were additionally calculated by using VLSM techniques that correlated lesion characteristics with postoperative scores.

Results
Mean lesion volumes were 13.3 ml for cingulotomy and 11.8 ml for limbic leucotomy. As expected, cingulotomy was isolated to the anterior cingulum. The subcaudate tractotomy portion of limbic leucotomy additionally affected Brodmann area 25, the medial orbitofrontal cortex, and the nucleus accumbens.
Initial results indicated that the dorsolateral regions of the cingulotomy lesion and the posteroventral regions of the subcaudate tractotomy lesion were associated with improved postoperative Yale-Brown Obsessive Compulsive Scale scores.

Conclusions
Cingulotomy and limbic leucotomy are lesioning surgeries that target pathological circuits implicated in psychiatric disease. Lesion analysis and VLSM contextualize outcome data and have the potential to be useful for improving lesioning neurosurgical procedures.
Staying Positive: Women's illness narratives and the stigmatized vernacular
Authors: Bock S. 
Published: November 2013

This article uses the stigmatized vernacular (Goldstein & Shuman, 2012) as a conceptual framework for examining the public construction and reception of women’s illness narratives. I begin by making the case that personal illness narratives – a genre that works to translate the subjective illness experience to a public audience – are rich sites for exploring how discourses of veneration and repudiation can become inextricably intertwined. Discussing illustrative examples of the construction and reception of women’s illness narratives shared in contexts of breast cancer and fibromyalgia, I show how popular understandings of emotions, particularly positive emotions like happiness, play a major role in the regimes of value shaping how women’s illness experiences become tellable or untellable, and thereby valued or devalued. Integrating scholarship on illness narratives, stigma, and happiness, I aim to contribute to a richer and more multifaceted view of the illness narrative genre and the discursive contagion of stigma.
As If You Have a Choice: Autism mothers and the remaking of the human
Authors: Douglas P. N. 
Published: November 2013

This paper utilizes feminist phenomenology to explore how contemporary representations of autism, and autism mothers, are integrally caught up in western (and now globalizing) understandings of health, happiness and the “normative” human. I examine the historical emergence of “autism mothers” as a new category of identity, and track this alongside a global autism mother recruitment campaign to get at what’s “behind” this phenomenon. I argue that emerging autism mother figures like the feminine warrior are new and contradictory neoliberal subjectivities that contain a most “hateful” unethical and increasingly global duty: the reinscription and intensification of the “normal” human as bourgeois, nondisabled, white and western, and the “new” femininity as “naturally” nurturing and necessarily instrumental. Even more, these new subjectivities are governmental, operating as western colonialist translations of happiness, compelling compulsory participation in increasingly limited, violent, and globalizing frames of normative humanity for us all.
Understanding Well-Being in Multi-Levels: A review
Authors: Ng E. C. W. , Fisher A. T. 
Published: November 2013

Well-being is not only an emerging research agenda, but also a critical issue concerning the individual as well as the societal development, because how the issue is viewed has a huge theoretical as well as practical, even policy, implication. In academic, while some argue that well-being is in the subjective perception of one’s life or psychological functioning, others argue that well-being is in the objective conditions and the broader environment. This paper, drawing on psychology tradition, tries to go beyond the dichotomy of well-being as either an individual attribute or external conditions. Instead, this article acknowledges the multi-levels of well-being are closely tied and should be taken into accounts when well-being is concerned. We will provide a brief review of the two major approaches – subjective well-being and quality of life – of well-being before the multi-level approach is introduced. The strength and challenges of the multilevel approach will be discussed.
Empirically Valid Principles for Training in the Real World
Authors: Healy Alice F. , Bourne Lyle E. 
Published: November 2013

Abstract
Four sets of cognitive psychology experiments are aimed to identify and empirically support principles of training intended to increase training effectiveness. Each set supports a different training principle: strategic use of knowledge (learning and memory are facilitated whenever preexisting knowledge can be used as a mediator in the process of acquisition), training difficulty (conditions that cause desirable difficulties during learning might facilitate later retention and transfer), mental practice (mental practice can retard forgetting and promote transfer of training, sometimes to a larger extent than can physical practice), and cognitive antidote (adverse effects of prolonged work on routine tasks can be mitigated by adding cognitive complications). The first 2 principles are focused on knowledge acquisition and the last 2 on skill acquisition. Nevertheless, the principles converge on similar prescriptions: Contrary to intuition and common practice, the trainer is recommended to increase the complexity of the training situation rather than use the simplest methods available.
Relevance of Piagetian Cross-Cultural Psychology to the Humanities and Social Sciences
Authors: Oesterdiekhoff Georg W. 
Published: November 2013

Abstract
Jean Piaget held views according to which there are parallels between ontogeny and the historical development of culture, sciences, and reason. His books are full of remarks and considerations about these parallels, with reference to many logical, physical, social, and moral phenomena. This article explains that Piagetian cross-cultural psychology has delivered the decisive data needed to extend the research interests of Piaget. These data provide a basis for reconstructing not only the history of sciences but also the history of religion, politics, morals, culture, philosophy, and social change and the emergence of industrial society. Thus, it is possible to develop Piagetian theory as a historical anthropology in order to provide a basis for the humanities and social sciences.
Progranulin, a Major Secreted Protein of Mouse Adipose-Derived Stem Cells, Inhibits Light-Induced Retinal Degeneration
Authors: Tsuruma Kazuhiro , Yamauchi Mika , Sugitani Sou , Otsuka Tomohiro , Ohno Yuta , Nagahara Yuki , Ikegame Yuka , Shimazawa Masamitsu , Yoshimura Shinichi , Iwama Toru , Hara Hideaki 
Published: November 2013

Abstract

Adipose tissue stromal vascular fraction contains mesenchymal stem cells, which show protective effects when administered to damaged tissues, mainly through secreted trophic factors. We examined the protective effects of adipose-derived stem cells (ASCs) and ASC-conditioned medium (ASC-CM) against retinal damage and identified the neuroprotective factors in ASC-CM. ASCs and mature adipocytes were isolated from mouse subcutaneous tissue. ASCs were injected intravitreally in a mouse model of light-induced retinal damage, and ASC injection recovered retinal function as measured by electroretinogram and inhibited outer nuclear layer, thinning, without engraftment of ASCs. ASC-CM and mature adipocyte-conditioned medium were collected after 72 hours of culture. In vitro, H2O2- and light-induced cell death was reduced in a photoreceptor cell line with ASC-CM but not with mature adipocyte-conditioned medium. In vivo, light-induced photoreceptor damage was evaluated by measurement of outer nuclear layer thickness at 5 days after light exposure and by electroretinogram recording. ASC-CM significantly inhibited photoreceptor degeneration and retinal dysfunction after light exposure. Progranulin was identified as a major secreted protein of ASCs that showed protective effects against retinal damage in vitro and in vivo. Furthermore, progranulin phosphorylated extracellular signal-regulated kinase, cAMP response element binding protein, and hepatocyte growth factor receptor, and protein kinase C signaling pathways were involved in the protective effects of progranulin. These findings suggest that ASC-CM and progranulin have neuroprotective effects in the light-induced retinal-damage model. Progranulin may be a potential target for the treatment of the degenerative diseases of the retina.
Hybride Tensidsysteme mit anorganischen Bestandteilen
Authors: Polarz Sebastian , Landsmann Steve , Klaiber Alexander 
Published: November 2013

AbstractTenside sind Moleküle mit großer wissenschaftlicher und technologischer Bedeutung, da sie häufig in Reinigungsmitteln, als Emulgatoren und zur Herstellung diverser Nanostrukturen verwendet werden. Ihre faszinierenden Eigenschaften in Bezug auf selbstorganisierte Strukturen wie Mizellen oder Flüssigkristalle entstammen ihrem amphiphilen Grundgerüst – eine polare Kopfgruppe verknüpft mit einer hydrophoben Kette. Während die meisten der bekannten Tenside rein organisch sind, entwickelt sich gerade eine neue Tensidfamilie, welche den amphiphilen Charakter mit der erweiterten Funktionalität von Übergangsmetallen kombiniert, z. B. Redox‐ oder katalytische Eigenschaften sowie Magnetismus. Diese hybriden Tenside weisen aufgrund der einzigartigen Größe und der elektronischen Eigenschaften der metallhaltigen Teile auch neuartige Merkmale in der Selbstorganisation auf.
Soluble‐eggshell‐membrane‐protein‐modified porous silk fibroin scaffolds with enhanced cell adhesion and proliferation properties
Authors: Sah Mahesh Kumar , Pramanik Krishna 
Published: November 2013

ABSTRACTIn this study, a porous silk fibroin (SF) scaffold was modified with soluble eggshell membrane protein (SEP) with the aim of improving the cell affinity properties of the scaffold for tissue regeneration. The pore size and porosity of the prepared scaffold were in the ranges 200–300 μm and 85–90%, respectively. The existence of SEP on the scaffold surface and the structural and thermal stability were confirmed by energy‐dispersive X‐ray spectroscopy, X‐ray diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. The cell culture study indicated a significant improvement in the cell adhesion and proliferation of mesenchymal stem cells (MSCs) on the SF scaffold modified with SEP. The cytocompatibility of the SEP‐conjugated SF scaffold was confirmed by a 3‐(4,5‐dimethyltriazol‐2‐y1)‐2,5‐diphenyl tetrazolium assay. Thus, this study demonstrated that the biomimic properties of the scaffold could be enhanced by surface modification with SEP. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014,131, 40138.
The Genus Pluchea: Phytochemistry, Traditional Uses, and Biological Activities
Authors: Hussain Hidayat , Al‐Harrasi Ahmed , Abbas Ghulam , Rehman Najeeb Ur , Mabood Fazal , Ahmed Ishtiaq , Saleem Muhammad , van Ree Teunis , Green Ivan R. , Anwar Saeed , Badshah Amin , Shah Afzal , Ali Iftikhar 
Published: November 2013

AbstractIn this review, literature data on phytochemical and biological investigations on the genus Pluchea are compiled. Pluchea is a genus of flowering plants in the Asteraceae family and comprises ca. 80 species distributed mainly in Northern and Southern America, Africa, Asia, and Australia. Sesquiterpenoids and flavonoids are the main constituents of this genus. Compounds isolated from plants of the Pluchea genus display a variety of biological properties, viz., anticancer, antileishmanial, immunosuppressive, antioxidant, anti‐acetylcholinesterase, antimicrobial, trypanocidal, hepatoprotective, cytotoxic, larvicidal, anti‐ulcer, anti‐inflammatory, and antinociceptive activities.
Chemical Composition and Antimicrobial Activity of the Essential Oil from the Edible Aromatic Plant Aristolochia delavayi
Authors: Li Zhi‐Jian , Njateng Guy S. S. , He Wen‐Jia , Zhang Hong‐Xia , Gu Jian‐Long , Chen Shan‐Na , Du Zhi‐Zhi 
Published: November 2013

AbstractThe essential oil obtained by hydrodistillation from the aerial parts of Aristolochia delavayi Franch. (Aristolochiaceae), a unique edible aromatic plant consumed by the Nakhi (Naxi) people in Yunnan, China, was investigated using GC/MS analysis. In total, 95 components, representing more than 95% of the oil composition, were identified, and the main constituents found were (E)‐dec‐2‐enal (52.0%), (E)‐dodec‐2‐enal (6.8%), dodecanal (3.35%), heptanal (2.88%), and decanal (2.63%). The essential oil showed strong inhibitory activity (96% reduction) of the production of bacterial volatile sulfide compounds (VSC) by Klebsiella pneumoniae, an effect that was comparable with that of the reference compound citral (91% reduction). Moreover, the antimicrobial activity of the essential oil and the isolated major compound against eight bacterial and six fungal strains were evaluated. The essential oil showed significant antibacterial activity against Providencia stuartii and Escherichia coli, with minimal inhibitory concentrations (MIC) ranging from 3.9 to 62.5 μg/ml. The oil also showed strong inhibitory activity against the fungal strains Trichophyton ajelloi, Trichophyton terrestre, Candida glabrata, Candida guilliermondii, and Cryptococcus neoformans, with MIC values ranging from 3.9 to 31.25 μg/ml, while (E)‐dec‐2‐enal presented a lower antifungal activity than the essential oil.
Chemical Variability of Cleistopholis patens (Benth.) Engl. et Diels Leaf Oil from Ivory Coast
Authors: Ouattara Zana Adama , Boti Jean Brice , Attioua Koffi Barthelemy , Ahibo Antoine Coffy , Casanova Joseph , Tomi Félix , Bighelli Ange 
Published: November 2013

AbstractThe chemical composition of 48 leaf oil samples isolated from individual plants of Cleistopholis patens (Benth.) Engl. et Diels harvested in four Ivoirian forests was investigated by GC‐FID (determination of retention indices), GC/MS, and 13C‐NMR analyses. The main components identified were β‐pinene (traces–59.1%), sabinene (traces–54.2%), (E)‐β‐caryophyllene (0.3–39.3%), linalool (0.1–38.5%), (E)‐β‐ocimene (0.1–33.2%), germacrene D (0.0–33.1%), α‐pinene (0.1–32.3%), and germacrene B (0–21.2%). The 48 oil compositions were submitted to hierarchical clustering and principal components analyses, which allowed the distinction of three groups within the oil samples. The oil composition of the major group (Group I, 33 samples) was dominated by (E)‐β‐caryophyllene and linalool. The oils of Group II (eight samples) contained mainly β‐pinene and α‐pinene, while those of Group III (seven samples) were dominated by sabinene, limonene, and β‐phellandrene. Moreover, the compositions of the Ivoirian C. patens leaf oils differed from those of Nigerian and Cameroonian origins.
Synthesis, Structure, and Reactivity of Lewis Base Stabilized Plumbacyclopentadienylidenes
Authors: Saito Masaichi , Akiba Tomoki , Kaneko Misumi , Kawamura Toshiaki , Abe Minori , Hada Masahiko , Minoura Mao 
Published: November 2013

AbstractPlumbacyclopentadienylidenes, in which the lead atoms have divalent states and are coordinated by THF, pyridine and N‐heterocyclic carbene, were synthesized and characterized. The THF‐ and pyridine‐stabilized compounds can be regarded as rare examples of hypervalent 10‐X‐4 species. The equilibrium between the THF adduct and the free plumbacyclopentadienylidene was evidenced by spectroscopic analysis and theoretical calculations. The THF adduct in benzene converted into a plumbylene dimer, where one of the lead centers is coordinated by THF and the other lead atom is coordinated by a divalent lead atom, the dimer gradually decomposing into spiroplumbole. The THF adduct unexpectedly reacted with trifluoroborane and trichlorogallane to afford fluoroborole and chlorogallole, which are the first examples of non‐annulated fluoroborole and gallole, respectively.
Development of Rhodesain Inhibitors with a 3‐Bromoisoxazoline Warhead
Authors: Ettari Roberta , Tamborini Lucia , Angelo Ilenia C. , Grasso Silvana , Schirmeister Tanja , Lo Presti Leonardo , De Micheli Carlo , Pinto Andrea , Conti Paola 
Published: November 2013

AbstractNovel rhodesain inhibitors were obtained by combining an enantiomerically pure 3‐bromoisoxazoline warhead with a specific peptidomimetic recognition moiety. All derivatives behaved as inhibitors of rhodesain, with low micromolar Ki values. Their activity against the enzyme was found to be paralleled by an in vitro antitrypanosomal activity, with IC50 values in the mid‐micromolar range. Notably, a preference for parasitic over human proteases, specifically cathepsins B and L, was observed.
Photosynthetic Antenna–Reaction Center Mimicry by Using Boron Dipyrromethene Sensitizers
Authors: El‐Khouly Mohamed E. , Fukuzumi Shunichi , D'Souza Francis 
Published: November 2013

AbstractVarious molecular and supramolecular systems have been synthesized and characterized recently to mimic the functions of photosynthesis, in which solar energy conversion is achieved. Artificial photosynthesis consists of light‐harvesting and charge‐separation processes together with catalytic units of water oxidation and reduction. Among the organic molecules, derivatives of BF2‐chelated dipyrromethene (BODIPY), “porphyrin’s little sister”, have been widely used in constructing these artificial photosynthetic models due to their unique properties. In these photosynthetic models, BODIPYs act as not only excellent antenna molecules, but also as electron‐donor and ‐acceptor molecules in both the covalently linked molecular and supramolecular systems formed by axial coordination, hydrogen bonding, or crown ether complexation. The relationships between the structures and photochemical reactivities of these novel molecular and supramolecular systems are discussed in relation to the efficiency of charge separation and charge recombination. Femto‐ and nanosecond transient absorption and photoelectrochemical techniques have been employed in these studies to give clear evidence for the occurrence of energy‐ and electron‐transfer reactions and to determine their rates and efficiencies.
Synthesis and Characterization of New Curcumin Derivatives as Potential Chemotherapeutic and Antioxidant Agents
Authors: Ciochina Roxana , Savella Chasity , Cote Brianna , Chang Davis , Rao Deepa 
Published: November 2013

Abstract

Preclinical Research

The purpose of this work was to synthesize a series of symmetrical analogs (CA2–CA7) of curcumin and determine their efficacy as antioxidant and anticancer agents in vitro. The six analogs were successfully synthesized and characterized, one of which, CA6, had not been previously reported in the literature. With the exception of CA2, the analogs had lower predicted aqueous solubilities and higher partition coefficients than curcumin. Two analogs, CA2 and CA3, had lower potencies as anticancer agents compared with curcumin, while CA6 had a slightly higher IC50 value. Two different trends in the antioxidant capabilities of curcumin and its analogs were determined when assessed in vitro or in cell culture. The in vitro DPPH assay clearly showed curcumin as the strongest antioxidant as compared with the analogs when tested at the same concentration or at their IC50 value. The cell culture‐based reactive oxygen species/reactive nitrogen species assay indicated that CA3 and CA6 were equal to curcumin in their free radical scavenging ability at the same concentration, but when curcumin and its analogs were tested at their respective IC50 values, CA4 and CA5 showed excellent antioxidant capacities. These results indicate that in cell culture, the ability of these analogs to produce antioxidant effects may be tied to their downstream effects.
Insights About the Mechanism of the Formation of Supramolecular π‐Stacked Rectangles Based on CuI Bimetallic Complexes Bearing a Bridging Phosphane Ligand
Authors: Nohra Brigitte , Reau Regis , Lescop Christophe 
Published: November 2013

AbstractThe variation in the ratio of the reactants in the supramolecular self‐assembly reaction of the bimetallic CuI “U‐shaped” molecular clip 1 with the 1,4‐dicyanobenzene 3 and the 1,8‐anthracene‐9,10‐carbonitrile 4 “short” ditopic ligand have allowed the observation of new “open” supramolecular assemblies 7 and 8, respectively, in addition to the previously characterized π‐stacked supramolecular rectangles 5 and 6, respectively. These new derivatives have been characterized by their solid‐state structure obtained by X‐ray diffraction on single crystals and by NMR spectroscopy in the case of derivative 7. Depending on the extent of the π system included in the core of the homoditopic linker, different behaviors are observed. In the case of derivative 7 based on the “phenyl” linker 3, a 1:1 1/3 ratio affords the open derivative in a good yield, whereas a 1:0.5 1/4 ratio allows the isolation of derivative 8 in very low yield. These results allow for a tentative analysis of the mechanism that occurs along with the supramolecular self‐assembly processes to afford π‐stacked supramolecular rectangles.
Electrocatalytic Oxidation of Amines on a Mediator‐Modified Electrode by Electrochemical Copolymerization of Nitroxyl Radical Precursor Containing Pyrrole Side Chain and Bithiophene
Authors: Kashiwagi Yoshitomo , Takamori Yumiko , Yoshida Kentaro , Ono Tetsuya 
Published: November 2013

AbstractThis paper describes the electrocatalytic oxidation of amines on TEMPO (2,2,6,6‐tetramethylpiperidine‐1‐oxyl)‐modified electrodes prepared by electrochemical copolymerization of TEMPO precursor containing pyrrole side chain and 2,2′‐bithiophene. The modified electrode exhibits electrocatalytic activity for the oxidation of primary and secondary amines. Cyclic voltammetric studies showed that the peak current of the cyclic voltammogram increased linearly with increasing concentration of amine in the sample solution.