bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
Authors: Danilo Christiane , Gutierrez-Pajares Jorge L , Mainieri Maria Antonietta , Mercier Isabelle , Lisanti Michael P , Frank Philippe G 
Published: September 2013

Abstract
Introduction
Previous studies have identified cholesterol as an important regulator of breast cancer development. High-density lipoprotein (HDL) and its cellular receptor, the scavenger receptor class B type I (SR-BI) have both been implicated in the regulation of cellular cholesterol homeostasis, but their functions in cancer remain to be established.

Methods
In the present study, we have examined the role of HDL and SR-BI in the regulation of cellular signaling pathways in breast cancer cell lines and in the development of tumor in a mouse xenograft model.

Results
Our data show that HDL is capable of stimulating migration and can activate signal transduction pathways in the two human breast cancer cell lines, MDA-MB-231 and MCF7. Furthermore, we also show that knockdown of the HDL receptor, SR-BI, attenuates HDL-induced activation of the phosphatidylinositol 3-kinase (PI3K)/protein Kinase B (Akt) pathway in both cell lines. Additional investigations show that inhibition of the PI3K pathway, but not that of the mitogen-activated protein kinase (MAPK) pathway, could lead to a reduction in cellular proliferation in the absence of SR-BI. Importantly, whereas the knockdown of SR-BI led to decreased proliferation and migration in vitro, it also led to a significant reduction in tumor growth in vivo. Most important, we also show that pharmacological inhibition of SR-BI can attenuate signaling and lead to decreased cellular proliferation in vitro. Taken together, our data indicate that both cholesteryl ester entry via HDL-SR-BI and Akt signaling play an essential role in the regulation of cellular proliferation and migration, and, eventually, tumor growth.

Conclusions
These results identify SR-BI as a potential target for the treatment of breast cancer.
Developing an early screening instrument for predicting psychological morbidity after critical illness
Authors: Schandl Anna , Bottai Matteo , Hellgren Elisabeth , Sundin Orjan , Sackey Peter V 
Published: September 2013

Abstract
Introduction
Guidelines recommend follow-up for patients after an intensive care unit (ICU) stay. Methods for identifying patients with psychological problems after intensive care would be of value, to optimize treatment and to improve adequate resource allocation in ICU follow-up of ICU survivors. The aim of the study was to develop a predictive screening instrument, for use at ICU discharge, to identify patients at risk for post-traumatic stress, anxiety or depression.

Methods
Twenty-one potential risk factors for psychological problems - patient characteristics and ICU-related variables - were prospectively collected at ICU discharge. Two months after ICU discharge 252 ICU survivors received the questionnaires Post-Traumatic Stress Symptom scale -10 (PTSS-10) and Hospital Anxiety and Depression Scale (HADS) to estimate the degree of post-traumatic stress, anxiety and depression.

Results
Of the 150 responders, 46 patients (31%) had adverse psychological outcome, defined as PTSS-10 >35 and/or HADS subscales ≥8. After analysis, six predictors were included in the screening instrument: major pre-existing disease, being a parent to children younger than 18 years of age, previous psychological problems, in-ICU agitation, being unemployed or on sick-leave at ICU admission and appearing depressed in the ICU. The total risk score was related to the probability for adverse psychological outcome in the individual patient. The predictive accuracy of the screening instrument, as assessed with area under the receiver operating characteristic curve, was 0.77. When categorizing patients in three risk probability groups - low (0 to 29%), moderate (30 to 59%) high risk (60 to 100%), the actual prevalence of adverse psychological outcome in respective groups was 12%, 50% and 63%.

Conclusion
The screening instrument developed in this study may aid ICU clinicians in identifying patients at risk for adverse psychological outcome two months after critical illness. Prior to wider clinical use, external validation is needed.
Endothelial Damage in Long-Term Survivors of Childhood Cancer
Authors: Brouwer Cornelia A.J. , Postma Aleida , Hooimeijer H. Louise H. , Smit Andries J. , Vonk Judith M. , van Roon Arie M. , van den Berg Maarten P. , Dolsma Wil V. , Lefrandt Joop D. , Bink-Boelkens Margreet T.E. , Zwart Nynke , de Vries Elisabeth G.E. , Tissing Wim J.E. , Gietema Jourik A. 
Published: September 2013

Purpose To evaluate the presence of vascular damage in long-term childhood cancer survivors (CCS) and sibling controls, and to evaluate the association between vascular damage parameters and cancer treatment and influence of cardiovascular risk factors. Patients and Methods Vascular assessment was performed in 277 adult CCSs (median age at diagnosis, 9 years; range, 0 to 20 years; median current age, 28 years; range, 18 to 48 years) treated with potentially cardiovascular toxic anticancer treatment (ie, anthracyclines, platinum, and/or radiotherapy [RT]). Measurements included carotid- and femoral-wall intima-media thickness (IMT), flow-mediated vasodilatation of the brachial artery by ultrasound, assessment of endothelial and inflammatory marker proteins (including tissue-type plasminogen activator [t-PA], plasminogen activator inhibitor type 1 [PAI-I]), and cardiovascular risk factors. CCS assessments were compared with those of 130 sibling controls (median age, 26 years; range, 18 to 51 years). Results At a median of 18 years (range, 5 to 31 years) after treatment, carotid and femoral IMTs in CCSs were not different from those of controls. However, CCSs who received RT as part of their treatment regimen had increased carotid and femoral IMTs and higher t-PA and PAI-I levels, indicating vascular damage and persistent endothelial activation. Patients treated with RT to the neck or chest also had greater femoral IMT. Greater IMT was associated with presence of cardiovascular risk factors (eg, hypertension and overweight). Conclusion After potentially cardiovascular toxic anticancer treatment, CCSs who received RT showed signs of endothelial damage and an unfavorable cardiovascular risk profile compared with controls. CCSs treated with localized RT had increased IMT outside the primary irradiation field. These abnormalities are probably involved in the pathogenesis of cardiovascular morbidity in CCSs.
Functional Decline in Older Patients With Cancer Receiving First-Line Chemotherapy
Authors: Hoppe Stéphanie , Rainfray Muriel , Fonck Marianne , Hoppenreys Laurent , Blanc Jean-Frédéric , Ceccaldi Joël , Mertens Cécile , Blanc-Bisson Christèle , Imbert Yves , Cany Laurent , Vogt Luc , Dauba Jérôme , Houédé Nadine , Bellera Carine A. , Floquet Anne , Fabry Marie-Noëlle , Ravaud Alain , Chakiba Camille , Mathoulin-Pélissier Simone , Soubeyran Pierre 
Published: September 2013

Purpose To determine factors associated with early functional decline during first-line chemotherapy in older patients. Patients and Methods Patients age ≥ 70 years receiving first-line chemotherapy for cancer were prospectively considered for inclusion across 12 centers in France. Functional decline was defined as a decrease of ≥ 0.5 points on the Activities of Daily Living (ADL) scale between the beginning of chemotherapy and the second cycle. Factors associated with functional decline were sought from pretreatment abbreviated comprehensive geriatric assessment, including ADL, Instrumental ADL (IADL), Mini-Nutritional Assessment (MNA), Mini–Mental State Examination (MMSE), Geriatric Depression Scale (GDS15), and Timed Get Up and Go (GUG) test, and from comorbidities (Cumulative Illness Rating Scale–Geriatrics), MAX2 index, and baseline biologic and clinical information. Results Of 364 included patients, 50 experienced functional decline (16.7%; median, 0.5 points). Abnormal preadmission performance status, IADL, GDS15, MMSE, GUG, and MNA were associated with increased likelihood of functional decline (univariate analysis). In the multivariate model adjusted for baseline ADL and MAX2 index, high baseline GDS (odds ratio [OR], 2.16; 95% CI, 1.09 to 4.30; P = .03) and low IADL scores (OR, 2.87; 95% CI, 1.06 to 7.79; P = .04) were independently associated with increased risk of functional decline. Conclusion Our results outline associations between baseline depression, instrumental dependencies, and early functional decline during chemotherapy for older patients. ADL should be sequentially evaluated early during treatment. Baseline evaluation of GDS15 and IADL may be proposed to anticipate this event.
Impact of Rituximab and Radiotherapy on Outcome of Patients With Aggressive B-Cell Lymphoma and Skeletal Involvement
Authors: Held Gerhard , Zeynalova Samira , Murawski Niels , Ziepert Marita , Kempf Barbara , Viardot Andreas , Dreyling Martin , Hallek Michael , Witzens-Harig Mathias , Fleckenstein Jochen , Rübe Christian , Zwick Carsten , Glass Bertram , Schmitz Norbert , Pfreundschuh Michael 
Published: September 2013

Purpose To study clinical presentation, outcome, and the role of radiotherapy in patients with aggressive B-cell lymphoma and skeletal involvement treated with and without rituximab. Patients and Methods Outcome of patients with skeletal involvement was analyzed in a retrospective study of nine consecutive prospective trials of the German High-Grade Non-Hodgkin lymphoma Study Group. Results Of 3,840 patients, 292 (7.6%) had skeletal involvement. In the MabThera International Trial (MInT) for young good-prognosis patients and the Rituximab With CHOP Over 60 Years (RICOVER-60) study for elderly patients, the randomized addition of rituximab improved event-free survival (EFS; hazard ratio for MInT [HRMInT] = 0.4, P > 001; hazard ratio for RICOVER-60 [HRRICOVER-60] = 0.6, P > .001) and overall survival (OS; HRMInT = 0.4, P < .001; HRRICOVER-60 = 0.7, P = .002) in patients without skeletal involvement, but failed to improve the outcome of patients with skeletal involvement (EFS: HRMInT = 1.4, P = .444; HRRICOVER-60 = 0.8, P = .449; OS: HRMInT = 0.6, P = .449; HRRICOVER-60 = 1.0, P = .935). Skeletal involvement was associated with a worse outcome after cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus rituximab (HREFS = 1.5, P = .048; HROS = 1.1; P = .828), but not after CHOP without rituximab (HREFS = 0.8, P = .181; HROS = 0.7, P = .083). In contrast to rituximab, additive radiotherapy to sites of skeletal involvement was associated with a decreased risk (HREFS = 0.3, P = .001; HROS = 0.5; P = .111). Conclusion Rituximab failed to improve the outcome of patients with diffuse large B-cell lymphoma with skeletal involvement, although our data suggest a beneficial effect of radiotherapy to sites of skeletal involvement. Whether radiotherapy to sites of skeletal involvement can be spared in cases with a negative positron emission tomography after immunochemotherapy should be addressed in appropriately designed prospective trials.
Marital Status and Survival in Patients With Cancer
Authors: Aizer Ayal A. , Chen Ming-Hui , McCarthy Ellen P. , Mendu Mallika L. , Koo Sophia , Wilhite Tyler J. , Graham Powell L. , Choueiri Toni K. , Hoffman Karen E. , Martin Neil E. , Hu Jim C. , Nguyen Paul L. 
Published: September 2013

Purpose To examine the impact of marital status on stage at diagnosis, use of definitive therapy, and cancer-specific mortality among each of the 10 leading causes of cancer-related death in the United States. Methods We used the Surveillance, Epidemiology and End Results program to identify 1,260,898 patients diagnosed in 2004 through 2008 with lung, colorectal, breast, pancreatic, prostate, liver/intrahepatic bile duct, non-Hodgkin lymphoma, head/neck, ovarian, or esophageal cancer. We used multivariable logistic and Cox regression to analyze the 734,889 patients who had clinical and follow-up information available. Results Married patients were less likely to present with metastatic disease (adjusted odds ratio [OR], 0.83; 95% CI, 0.82 to 0.84; P < .001), more likely to receive definitive therapy (adjusted OR, 1.53; 95% CI, 1.51 to 1.56; P < .001), and less likely to die as a result of their cancer after adjusting for demographics, stage, and treatment (adjusted hazard ratio, 0.80; 95% CI, 0.79 to 0.81; P < .001) than unmarried patients. These associations remained significant when each individual cancer was analyzed (P < .05 for all end points for each malignancy). The benefit associated with marriage was greater in males than females for all outcome measures analyzed (P < .001 in all cases). For prostate, breast, colorectal, esophageal, and head/neck cancers, the survival benefit associated with marriage was larger than the published survival benefit of chemotherapy. Conclusion Even after adjusting for known confounders, unmarried patients are at significantly higher risk of presentation with metastatic cancer, undertreatment, and death resulting from their cancer. This study highlights the potentially significant impact that social support can have on cancer detection, treatment, and survival.
Phase II Trial of Palliative Radiotherapy for Hepatocellular Carcinoma and Liver Metastases
Authors: Soliman Hany , Ringash Jolie , Jiang Haiyan , Singh Kawalpreet , Kim John , Dinniwell Robert , Brade Anthony , Wong Rebecca , Brierley James , Cummings Bernard , Zimmermann Camilla , Dawson Laura A. 
Published: September 2013

Purpose To evaluate the feasibility and response of liver radiotherapy (RT) in improving symptoms and quality of life in patients with hepatocellular carcinoma (HCC) or liver metastases (LM). Patients and Methods Eligible patients had HCC or LM, unsuitable for or refractory to standard therapies, with an index symptom of pain, abdominal discomfort, nausea, or fatigue. The Brief Pain Inventory (BPI), Functional Assessment of Cancer Therapy–Hepatobiliary (FACT-Hep), and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) were completed by patients at baseline and each follow-up. The primary outcome was the percentage of patients with a clinically significant change at 1 month in the BPI subscale of symptom on average in the past 24 hours. Secondary outcomes were improvement in other BPI subscales and at other time points, FACT-Hep and EORTC QLQ-C30 at each follow-up, and toxicity at 1 week. Results Forty-one patients (30 men and 11 women) with HCC (n = 21) or LM (n = 20) were accrued. At 1 month, 48% had an improvement in symptom on average in the past 24 hours. Fifty-two percent of patients had improvement in symptom at its worst, 37% at its least, and 33% now. Improvements in the FACT-G and hepatobiliary subscale were seen in 23% and 29% of patients, respectively, at 1 month. There were also improvements in EORTC QLQ-C30 functional (range, 11% to 21%) and symptom (range, 11% to 50%) domains. One patient developed grade 3 nausea at 1 week. Conclusion Improvements in symptoms were observed at 1 month in a substantial proportion of patients. A phase III study of palliative liver RT is planned.
O Melhoramento Genético de Cana-de-Açúcar no Brasil e o Desafio das Mudanças Climáticas Globais
Authors: Carvalho Silvia Angélica Domingues de , Furtado Andre Tosi 
Published: September 2013

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2013.2.1.4909.22-46.Diante dos desafios colocados pelas mudanças climáticas, o Brasil precisa promover o crescimento sustentado da produção de cana-de-açúcar para atender à crescente demanda. A expansão da produção depende do desenvolvimento de variedades adaptadas ao solo e ao clima das novas áreas de expansão. O setor sucroalcooleiro nacional possui instituições historicamente responsáveis pelos avanços no desenvolvimento tecnológico e de inovação no setor. Então, identificar os principais desafios tecnológicos que essas instituições, em seus programas de melhoramento, têm encontrado é vital para o Brasil manter a liderança na produção de cana-de-açúcar. Nesta pesquisa, verificou-se que, apesar dos recursos tecnológicos existentes, os desafios colocados pelas novas condições climáticas e as mudanças na regulamentação setorial impõem limitações que devem ser superadas: o tempo de colocação de uma variedade no mercado; as dificuldades de infraestrutura interna; as dificuldades na transmissão de conhecimentos aos produtores; a falta de apoio do governo; a complexidade genética de cana-planta; entre outros.
Eurhythmatic analysis: A rhetoric of adaptation
Authors: Wallin Mark Rowell 
Published: September 2013

Abstract
This article proposes that many of the persistent and nagging problems that plague adaptation studies can be solved by consideration of the ancient and modern invocations of the rhetorical term Eurhythmia. Adaptation studies – or the analysis of the ways texts are changed as they are transplanted from mode to mode – constantly struggles to resist the impulse to denigrate new textual instantiations out of hand as ‘less than’ a revered form, bestowing a metaphor of emanation and corruption on the adaptation. A eurhythmatic approach, conversely, advocates the use of rhetorical strategies arising out of considerations of audience, purpose and context, in order to analyse these modal shifts. Being first concerned with ‘the right fit for the right purpose’, eurhythmia gives us the tools to see adaptations in a constellation of textual associations and material contexts that in turn allow us to understand why some adaptations succeed and why others fail.
Wuthering Heights: A radio adaptation
Authors: Gough Lucy 
Published: September 2013

Abstract
A radio adaptation of Emily Brontë’s Novel Wuthering Heights commissioned by the BBC for the Radio 4 Woman’s Hour series. This adaptation is spread over fifteen episodes and deliberately gives the second half of the book as much time as the more popular first half. This version has also deliberately embraced the medium of radio, hence the house ‘Wuthering Heights’ has been given a voice. Hopefully this brings the world of the book directly into the mind of the listener, with all the brooding passion, cruelty, and darkness it contains. It is a novel of extremes, love and hate, hell and heaven, life and death, man and beast it is also about breaking boundaries and promises. I hope by paring the book back to its bones I have managed to capture some of this in its new form.
Anthony Minghella: Aautobiographical memory and the creation of an adapted screenplay
Authors: Dickenson Sarah Jane 
Published: September 2013

Abstract
The following article uses as its source material interviews with the director and screenwriter Anthony Minghella which I carried out between 2003 and 2006. Minghella approached the adaptation of a novel in a particular way and I would contend he adapted autobiographical memories in the same way he adapted novels. In this article I will consider how Minghella drew on his memories both of the texts he adapted and his autobiographical memories in order to create screenplays.
This side of paradise: Immersion and emersion in S3D and AR
Authors: Asselin Olivier , Auger Louis 
Published: September 2013

Abstract
S3D and AR, emergence and augmentation, have certain similarities, for both call into question the surface of the image on the side of the viewer by introducing virtual elements into real space. A comparative analysis of the two strategies reveals that the mimetic program that largely structures the production and reception of technical images is not centred squarely on illusion, but more generally on immersion and more particularly on egocentric spatial immersion, which perceptually places the viewer at the centre of the virtual world. But at the present time, as they have developed so far, S3D and AR are imperfect responses to this ideal.
Colin Low and Transitions 3D: Innovating immersive cinema
Authors: Smith David Harris 
Published: September 2013

Abstract
Transitions 3D is significant to film scholars because it is the first stereoscopic live-action IMAX film. The film also anchors important histories of Canadian film innovation and culture. From a technical perspective these histories include the development of large format cinema cameras and projection systems, early computer animation, and immersive cinema exhibition architecture. From a cultural perspective, Transitions 3D was the culmination of a prolific and wide flung collaboration of Canadian film-makers and technologists that was forged in response to the cultural mandates of the NFB and the national showcase agendas of successive world expositions. Low’s nuanced modernist ideology coupled with his sustained artistic and technical experimentation were central to these developments, driven in particular by his quest for an immersive cinema that would unite the film viewer and film subject in a stereoscopic cinematic space.
Perceptual artefacts, suspension of disbelief and realism in stereoscopic 3D film
Authors: Allison Robert S. , Wilcox Laurie M. , Kazimi Ali 
Published: September 2013

Abstract
Stereoscopic film has long held an allure as the ultimate in fidelity for cinema and, as such, been a goal for those seeking the most compelling illusion of reality. However, the fundamental and technical limitations of the medium introduce a number of artefacts and imperfections that impact the viewer experience. The renaissance of stereoscopic three-dimensional (S3D) film requires that film-makers revisit assumptions and conventions about factors that influence the visual appreciation and impact of their medium. This article will discuss a variety of these issues from a perceptual standpoint and their implications for depth perception, visual comfort and sense of scale. The impact of these perceptual artefacts on the suspension of disbelief and the creation of alternate realities is discussed as is their deliberate use when artistic considerations demand breaks with realism.
For your glasses only: The Stewardesses and sex in three dimensions
Authors: Duerfahrd Lance 
Published: September 2013

Abstract
The Stewardesses (1969) is an unjustifiably neglected experiment in 3-D cinema. The first in a series of hard- and soft-core pornographic features in three dimensions produced in the 1970s, it provides critical opportunity to review a ‘truism’ of media studies: that pornography drives the invention of new technologies. The Stewardesses unwitting reveals how our desire for technology (our wonder at the capacity of film to reach into our space) is at odds with our desire for what it purveys (bodies in states of desire). The film makes us aware of how a 3-D film arouses our glasses, not our eyes. Since 3-D camera lenses could not provide close-ups, the film works without a key ingredient of the pornographic vocabulary. Through 3-D technology, The Stewardesses produces a strange new genre: pornography that fosters attention to peripheral spaces and that discourages the traditional monomaniacal or cyclopic focus of the spectator of pornography.