bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness, safety, and treatment pattern of sodium zirconium cyclosilicate in Chinese patients with hyperkalemia: interim analysis from a multicenter, prospective, real-world study (Actualize Study)
Authors: Shen Nan , Zhang Lihong , Yang Jing , Lin Yongqiang , Liu Xinyu , Cai Xudong , Cao Juan , Zhu Qiang , Luo Xun , Wan Xin , Wu Henglan , Ye Jianming , Shan Chunyan , Xie Hua , Wu Yifan , Cao Yanping , Wang Jianmin , Yu Xiaoyong , Wang Huimin , He Jingdong , Tian Shaojiang , Wu Fenglei , Jiang Xinxin , Li Lu , Zuo Li , Wang Zhaohua , Xing Changying , Yin Xun , Zhao Jianrong , Ma Cong , Long Gang , Li Qing , Hu Yao , Shi Yifan , Lin Hongli 
Published: July 2024

Introduction: Sodium zirconium cyclosilicate (SZC) is a nonabsorbed cation-exchanger approved in China for the treatment of hyperkalemia [HK; serum potassium (sK+) levels &gt;5.0 mmol/L]. This is the first real-world study aimed to assess the effectiveness, safety, and treatment patterns of SZC in Chinese patients with HK. Here we present the results of the first interim analysis.Methods: This multicenter, prospective, cohort study included patients aged ≥18 years with documented HK within 1-year before study enrollment day. These patients were followed up for 6 months from the enrollment day after initiating SZC treatment. The treatment was categorized into correction phase (FAS-P1) and maintenance phase (FAS-P2 new and ongoing users). Subgroup analysis was performed in patients on hemodialysis (FAS-H). The primary objective was evaluation of safety profile of SZC; secondary objectives included assessment of treatment patterns of SZC and its effectiveness.Results: Of 421 screened patients, 193, 354, and 162 patients were enrolled in the FAS-P1, FAS-P2, and FAS-H groups, respectively. sK+ levels were reduced significantly from 5.9 mmol/L to 5.0 mmol/L after the correction phase. For the maintenance phase, the mean sK+ levels were maintained at 5.2 mmol/L and 5.0 mmol/L in the FAS-P2 new and ongoing user, respectively, and 5.3 mmol/L in the FAS-H subgroup. A considerable proportion of patients showed normokalemia after 48 h of SZC treatment (FAS-P1:51.3%) which was maintained up to 6 months in the maintenance phase (FAS-P2:44%). SZC was well-tolerated.Conclusion: SZC was effective and safe for the treatment of HK in real-world clinical practice in China.
Searching for the perfect goalkeeping personality. Myth or reality?
Authors: Spielmann Jan , Otte Fabian , Schumacher Tom , Mayer Jan , Klatt Stefanie 
Published: July 2024

BackgroundPsychological factors such as personality characteristics are influential factors of the goalkeeping performance in football (soccer). Not only for individualized treatment in practice, also from a scientific point of view, profiling goalkeepers is a relevant part of understanding athletes. The aim of this study was to investigate personality traits of goalkeepers of different expertise, age, and sex.MethodsUsing the Five Factor Model of personality we assessed personality traits of 132 male and female football goalkeepers ranging from youth to senior and low to elite level. A series of analysis investigated differences between the groups focusing on expertise, age, and sex.ResultsSignificant differences in the personality trait agreeableness between groups of different expertise and sex could be detected. Although a significant difference in neuroticism levels of males and females could be shown.ConclusionThis study was a first step of profiling football goalkeepers of different expertise, age, and sex. The study calls for more replication in this specific field of football and goalkeeping in general to understand the influence of personality characteristics on sport performance.
Comparative Analysis of Technological Indicators Development Regions of the Volga Federal District
Authors: Казакова О.Б. 
Published: July 2024

В статье рассмотрены ключевые характеристики технологического развития и на основе мирового опыта выделены его основные тенденции. Проведен сравнительный анализ некоторых показателей технологического развития регионов ПФО, позволивший обозначить позицию каждого из них в обеспечении технологических изменений, направленных на выпуск высокотехнологичной продукции, востребованной рынком. Полученные результаты могут быть положены в основу мероприятий по активизации кооперационного и интеграционного взаимодействия в межрегиональном пространстве.
The article discusses the key characteristics of technological development and, based on international experience, highlighted its main trends. A comparative analysis of some indicators of the technological development of the regions of the Volga Federal District was carried out, which made it possible to indicate the position of each of them in ensuring technological changes aimed at producing high-tech products demanded by the market. The results obtained can be used as a basis for measures to enhance cooperation and integration interaction in the interregional space.
Efficacy of New Oral Anticoagulants Compared to Warfarin in Different Age Groups of Patients with Atrial Fibrillation: A Literature Review
Authors: Кармильцына А.М. , Куксенко Ю.А. , Бутолина Ю.К. , Хечумян А.Г. , Елисеев А.В. 
Published: July 2024

Фибрилляция предсердий (ФП) значительно увеличивает риск тромбоэмболических осложнений, особенно инсульта, что делает антикоагулянтную терапию критически важной для предотвращения данных осложнений. В статье подробно рассматривается ФП, наиболее частая устойчивая форма аритмии, представляющая собой значительную проблему для общественного здравоохранения глобального масштаба. Сосредоточиваясь на данных о частоте новых случаев ФП за период с 2009 по 2022 г., исследование анализирует возрастные характеристики пациентов при первичном скрининге. Объектом изучения стала группа из 8429 человек в возрасте от 45 до 69 лет, не сталкивавшихся до этого с сердечно-сосудистыми заболеваниями и ФП. В ходе исследования было обнаружено, что с увеличением возраста пациентов риск развития ФП значимо возрастает. Также проведено сравнение традиционных антикоагулянтов, включая варфарин, с новыми оральными антикоагулянтами (НОАК). Основываясь на данных из крупных клинических исследований, анализируется эффективность, безопасность и воздействие на качество жизни пациентов обеих групп препаратов. Результаты подтверждают, что НОАК обладают лучшим профилем эффективности и безопасности по сравнению с варфарином, предлагая важные преимущества, включая уменьшенный риск серьезных кровотечений и улучшение качества жизни пациентов. Полученные данные и выводы могут послужить для разработки стратегий общественного здравоохранения и предложения целевых мер профилактики, адаптированных к возрастным группам, наиболее подверженным риску.
Atrial fibrillation significantly increases the risk of thromboembolic complications, especially stroke, making anticoagulant therapy critically important for preventing these complications. This paper provides a detailed examination of atrial fibrillation (AF), the most common persistent form of arrhythmia, representing a significant global public health issue. Focusing on data regarding the incidence of new AF cases from 2009 to 2022, the study analyzes the age characteristics of patients at initial screening. The subject group consisted of 8,429 individuals aged 45 to 69 years who had not previously encountered cardiovascular diseases and atrial fibrillation. The research found that the risk of developing AF significantly increases with patient age. A comparison of traditional anticoagulants, including warfarin, with new oral anticoagulants (NOACs) was also conducted. Based on data from major clinical trials, the efficacy, safety, and impact on patients’ quality of life of both drug groups are analyzed. The results confirm that NOACs possess a better efficacy and safety profile compared to warfarin, offering significant advantages, including a reduced risk of serious bleeding and improved quality of life for patients. The findings and conclusions can serve in the development of public health strategies and the proposal of targeted prevention measures, adapted to age groups most at risk.
A Computer Laboratory for the Calculation of the Heat Capacity of a Peptide Unfolding Transition
Authors: Grøndahl Lau Blom , Schuhmann Fabian , Bruhn Dennis , Dubey Vikas , Solov’yov Ilia A. , Khandelia Himanshu 
Published: July 2024

ABSTRACT
We present the implementation of a computer simulation laboratory for the calculation of the heat capacity of the folding-unfolding pseudo phase transition of a polyalanine Ala30 α-helix, using molecular dynamics simulations. Unlike conventional calorimetry experiments, which provide a macroscopic interpretation of the heat capacity, the computer laboratory additionally offers a molecular perspective of the energy exchange processes that lead to the peak of the heat capacity at the phase transition, as well as the statistical mechanical interpretation of the phase transition. The exercise is targeted toward 1st- or 2nd-year students of biophysics in the context of an undergraduate physical chemistry course. We use a graphical web interface to overcome the steep learning barriers associated with command line interactions in commonly used molecular dynamics protocols. The web interface (VIKING) also handles communication with computing hardware in the background, so that students with limited or no programming experience can launch and analyze the simulations easily. A collaboration between the VIKING support team and responsible teachers is required to set up VIKING. We also present a solution in which simulations can be launched on students’ own computers, if some command line knowledge can be expected. The laboratory can also be repurposed for students of various backgrounds (physics, chemistry, biology, or engineering) and scholastic levels (undergraduate or graduate).
PENERAPAN METODE SUPPORT VECTOR MACHINE DALAM CLASSIFIKASI ULASAN PENGGUNA APLIKASI MOBILE JKN
Authors: Sugihartono Tri , Putra Rendy Rian Chrisna 
Published: July 2024

Aplikasi JKN Mobile telah menjadi salah satu sarana utama bagi masyarakat Indonesia untuk mengakses layanan kesehatan yang disediakan oleh program Jaminan Kesehatan Nasional (JKN). Dalam konteks ini, analisis sentimen ulasan pengguna aplikasi JKN Mobile menjadi penting untuk memahami persepsi dan pengalaman pengguna. Dalam penelitian ini menggunakan metode klasifikasi SVM untuk melakukan analisis sentimen secara mendalam terhadap ulasan pengguna aplikasi JKN Mobile. Langkah-langkah penelitian meliputi pengumpulan data ulasan pengguna, preprocessing data, ekstraksi fitur, pembagian data, pelatihan model SVM, dan evaluasi kinerja model. Data ulasan pengguna dikumpulkan dan diproses, lalu dilatih menggunakan model SVM untuk mengklasifikasikan sentimen ulasan menjadi positif, negatif, atau netral. Penelitian ini melakukan pengujian tingkat akurasi dengan perbandingan pembagian data training dengan data testing. Tujuan dari metode ini adalah untuk mengeksplorasi berbagai teknik optimasi untuk meningkatkan akurasi model SVM dalam klasifikasi sentimen ulasan pengguna aplikasi JKN Mobile. Ini bisa mencakup penggunaan algoritma optimasi seperti Particle Swarm Optimization (PSO) untuk menemukan parameter terbaik bagi model SVM. Hasil penelitian menunjukkan Tingkat akurasi SVM setelah penerapan PSO atau Grid Search mengalami peningkatan akurasi yang awalnya tingkat akurasi SVM sebesar 81%, setelah optimasi, tingkat akurasi mendapatkan akurasi yang lebih tinggi sebesar 85 %.
PAISAGEM URBANA E SEGREGAÇÃO SOCIOESPACIAL EM ILHÉUS
Authors: Silva de Andrade Érica Dos Santos , Trindade Gilmar Alves 
Published: July 2024

A produção do espaço urbano em Ilhéus-BA se dá, historicamente, de forma contraditória e desigual, e a paisagem urbana das zonas Norte e Sul da cidade revela, de imediato, essa contradição; ao norte, territórios das classes populares, majoritariamente; ao sul, territórios mais valorizados para as classes mais abastadas e para a realização dos interesses de ampliação do capital vinculado ao setor imobiliário. O presente trabalho faz uma breve explanação acerca de como se deu a organização espacial de Ilhéus, uma breve apresentação da organização interna da cidade e como se manifesta a segregação socioespacial que se apresenta na paisagem urbana da cidade. Trata-se de uma pesquisa explicativa, qualitativa e de caráter bibliográfico. A pesquisa contou com a coleta de dados secundários com idas à campo para obtenção de fotografias e preenchimento das fichas de observação acerca dos bairros visitados. Os resultados apresentam que a segregação socioespacial existente na cidade ocorre em função dos modos de apropriação e valorização seletiva do solo urbano pelo capital, na zona sul da cidade; como também devido às disparidades entre a oferta dos serviços e equipamentos urbanos para as áreas mais nobres e para os bairros periféricos.
The electronic catalog of periodicals in the system of remote services of the VNLU
Authors: Turovska Lesia , Krutova Roksana , Stakhovska Antonina 
Published: July 2024

The object of the research is the electronic catalog of periodicals as a component of the electronic bibliographic resources of the Vernadsky National Library of Ukraine (VNLU). The subject of the study is the formation and use of the electronic catalog of periodicals of the VNLU in the library and bibliographic service system of the scientific library. The purpose of the article is to describe the scientific characteristics of the electronic catalog of periodicals of the VNLU, to determine its role in remote library and information services, to substantiate the relevance of its further formation and development. Methodological basis of research: analysis, synthesis, historical, terminological, comparative, generalizing approaches. Scientific novelty. Expanding professional ideas about the essence and functions of electronic resources of own generation using the example of the electronic catalog of periodicals; determination of the range of possibilities of its use in the system of library and bibliographic services; outlining directions for its further development as a component of electronic bibliographic resources of a scientific library. Conclusions. Involvement of the electronic catalog of periodicals in everyday virtual library and bibliographic practice determines the optimization of scientific, educational, industrial, cultural, educational and other social processes and turns into an important factor of domestic innovative development. The experience of creating and maintaining the electronic catalog of periodicals of the VNLU will contribute to the formation of bibliographic and search systems. It improves their quality and efficiency of use, contribute to the implementation of the latest strategy for the formation of a branch reference and bibliographic resource, and increase the level of satisfaction of scientific and informational professional needs of users, which will have an impact on the intensity of development in Ukraine of scientific thought. Practical significance and prospects. Further plans include researching the information and search capabilities of the electronic catalog of periodicals of the VNLU EC and the forms of library and bibliographic service for users based on its content, as well as outlining the ways of the scientific library's further strategy for the formation and use of its own generation database.
Design and Build of Dacron Pillow Filling Machine to Increase Production Capacity and Reduce Production Costs
Authors: Carendy Indrawan  , Murnawan Hery 
Published: July 2024

This research was conducted at Mr. Khambali's SME. Mr. Khambali's pillow SME is engaged in producing pillows and bolsters with an average daily production of 140 units. The problemin Mr. Khambali's pillow SME is that the production output often does not meet demand because the process of stuffing the dacron into the pillow sack takes 8 minutes. This research aims to increase production capacity and reduce production costs. The method used in this research is Anthropometry, which is a reference for designing the machine to ensure its safe and comfortable use. Then, work time measurement is conducted using the time study method, and the calculation of production costs is compared before and after the design process. The results obtained from the design process are an increase in production from 140 units to 230 units per day and a reduction in production costs from IDR. 23,801 to IDR. 14,705. This research concludes that after designing the Dacron pillow-filling device, production increased by 90 units, and production costs decreased by IDR. 9,096.
CONTROVERSIAL DISAPPEARANCE AND UNETHICAL BUSINESS PRACTICES: A CASE OF X-MOBILE
Authors: Rasool Shahid , Shaikh Erum , Sabir Chaudhry Iffat , Nawaz Tunio Muhammad 
Published: July 2024

Learning Outcomes
On completion of case reading the student will be able to: (1) To recognize the significance of business ethics on its market reputation; (2) To interpret the strategic implications of bad decisions on company reputation; (3) To identify the legal and administrative lapses in the governance system that fail to nip fraudulent operations as smuggling, and tax envisions in the bud; (4) To evaluate the professional and ethical attitude towards regulatory laws and corporate structures related to local and international business.
Case overview/synopsis
In this case, the unethical business practices, and decisions of X-Mobile company (distinguished name) are analyzed that led the emerging market leader among local mobile vendors to a bad reputation and loss of market shares in no time. In Pakistan, the smartphone penetration remained at 36% in the year 2021, almost 3 times higher compared to the year 2014 (PACRA, 2021). The global manufacturing companies are the key suppliers of mobile phones to the local market as the domestic mobile market is largely imported drive. The major suppliers include Apple, Samsung, Oppo, Huawei, Xiaomi, and other Chinese brands. X-Mobile took advantage of the gap and started its operations in Pakistan by establishing its mobile assembling unit and distribution network in the region. In less than a decade, the company grabbed a larger chunk of the market shares of rural Pakistan’s smartphone industry. As the X-Mobile smartphone demand increased, the company was unable to cope with the supply of its products to the customer due to its unethical business practices of tax evasion (scandal of 2017), the bankruptcy of its vendor (ABC), over advertising budget, and mismanagement of its brand reputation. This resulted in the temporary ban of the company by the Pakistan Telecom Authority (PTA) from conducting its operations in Pakistan which pushed the company into shambles, tax shaming, reduction of market share, and the influx of several smartphone brands from China to fill in the market gap. Now outstanding smartphones from Xiaomi, Oppo, Vivo, and Infinix are easily available in the far-flung areas of the country. The case discusses the company's initial tactics to become a leading smartphone brand in a short span of ten years and its current struggle to reposition itself and reclaim its lost market shares subsequent to its involvement in unethical business practices and tax evasion.
Supplement materials
Supporting materials are available for the student (Teaching Notes).
Complexity/ Academic level
Undergraduate Level - This case is ideally suited for classroom discussions for students of management sciences undertaking courses on Business Ethics, Brand Management, Strategic Marketing, International Business, and Corporate Governance.
SuperSynthIA: Physics-ready Full-disk Vector Magnetograms from HMI, Hinode, and Machine Learning
Authors: Wang Ruoyu , Fouhey David F. , Higgins Richard E. L. , Antiochos Spiro K. , Barnes Graham , Hoeksema J. Todd , Leka K. D. , Liu Yang , Schuck Peter W. , Gombosi Tamas I. 
Published: July 2024

Abstract
Vector magnetograms of the Sun’s photosphere are cornerstones for much of solar physics research. These data are often produced by data-analysis pipelines combining per-pixel Stokes polarization vector inversion with a disambiguation that resolves an intrinsic 180° ambiguity. We introduce a learning-based method, SuperSynthIA, that produces full-disk vector magnetograms from Stokes vector observations. As input, SuperSynthIA uses Stokes polarization images from Solar Dynamics Observatory (SDO)/Helioseismic and Magnetic Imager (HMI). As output, SuperSynthIA simultaneously emulates the inversion and disambiguation outputs from the Hinode/Solar Optical Telescope-Spectro-Polarimeter (SOT-SP) pipeline. Our method extends our previous approach SynthIA with heliographic outputs as well as using an improved data set and inference method. SuperSynthIA provides a new tool for improved magnetic fields from full-disk SDO/HMI observations using information derived from the enhanced capabilities of Hinode/SOT-SP. Compared to our previous SynthIA, SuperSynthIA provides physics-ready vector magnetograms and mitigates unphysical angle preferences and banding artifacts in SynthIA. SuperSynthIA data are substantially more temporally consistent than those from the SDO/HMI pipeline, most notably seen in, e.g., evolving active regions. SuperSynthIA substantially reduces noise in low-signal areas, resulting in less center-to-limb bias outside of strong-signal areas. We show that outputs from SuperSynthIA track the SDO/HMI-recorded evolution of the magnetic field. We discuss the limitations of SuperSynthIA that the user must understand, and we demonstrate a broad set of evaluations to test SuperSynthIA and discuss remaining known artifacts. Our tests provide both methodology and evidence that SuperSynthIA outputs are ready for use by the community, and that learning-based approaches are suitable for physics-ready magnetograms.
A New Asteroseismic Kepler Benchmark Constrains the Onset of Weakened Magnetic Braking in Mature Sun-like Stars
Authors: Bhalotia Vanshree , Huber Daniel , van Saders Jennifer L. , Metcalfe Travis S. , Stassun Keivan G. , White Timothy R. , Aguirre Børsen-Koch Víctor , Ball Warrick H. , Basu Sarbani , Serenelli Aldo M. , Sawczynec Erica , Guzik Joyce A. , Howard Andrew W. , Isaacson Howard 
Published: July 2024

Abstract
Stellar spin down is a critical yet poorly understood component of stellar evolution. In particular, results from the Kepler Mission imply that mature age, solar-type stars have inefficient magnetic braking, resulting in a stalled spin-down rate. However, a large number of precise asteroseismic ages are needed for mature (≥3 Gyr) stars in order to probe the regime where traditional and stalled spin-down models differ. In this paper, we present a new asteroseismic benchmark star for gyrochronology discovered using reprocessed Kepler short cadence data. KIC 11029516 (Papayu) is a bright (Kp = 9.6 mag) solar-type star with a well-measured rotation period (21.1 ± 0.8 days) from spot modulation using 4 yr of Kepler long-cadence data. We combine asteroseismology and spectroscopy to obtain T
eff = 5888 ± 100 K, [Fe/H] = 0.30 ± 0.06 dex, M = 1.24 ± 0.05 M
⊙, R = 1.34 ± 0.02 R
⊙, and age of 4.0 ± 0.4 Gyr, making Papayu one of the most similar stars to the Sun in terms of temperature and radius with an asteroseismic age and a rotation period measured from spot modulation. We find that Papayu sits at the transition of where traditional and weakened spin-down models diverge. A comparison with stars of similar zero-age main-sequence temperatures supports previous findings that weakened spin-down models are required to explain the ages and rotation periods of old solar-type stars.