bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is There an Optimal ENSO Pattern That Enhances Large-Scale Atmospheric Processes Conducive to Tornado Outbreaks in the United States?
Authors: Lee Sang-Ki , Atlas Robert , Enfield David , Wang Chunzai , Liu Hailong 
Published: September 2012

Abstract
The record-breaking U.S. tornado outbreaks in the spring of 2011 prompt the need to identify long-term climate signals that could potentially provide seasonal predictability for U.S. tornado outbreaks. This study uses both observations and model experiments to show that a positive phase TransNiño may be one such climate signal. Among the top 10 extreme outbreak years during 1950–2010, seven years including the top three are identified with a strongly positive phase TransNiño. The number of intense tornadoes in April–May is nearly doubled during the top 10 positive TransNiño years from that during 10 neutral years. TransNiño represents the evolution of tropical Pacific sea surface temperatures (SSTs) during the onset or decay phase of the El Niño–Southern Oscillation. A positive phase TransNiño is characterized by colder than normal SSTs in the central tropical Pacific and warmer than normal SSTs in the eastern tropical Pacific. Modeling experiments suggest that warmer than normal SSTs in the eastern tropical Pacific work constructively with colder than normal SSTs in the central tropical Pacific to force a strong and persistent teleconnection pattern that increases both the upper-level westerly and lower-level southwesterly over the central and eastern United States. These anomalous winds advect more cold and dry upper-level air from the high latitudes and more warm and moist lower-level air from the Gulf of Mexico converging into the east of the Rockies, and also increase both the lower-tropospheric (0–6 km) and lower-level (0–1 km) vertical wind shear values therein, thus providing large-scale atmospheric conditions conducive to intense tornado outbreaks over the United States.
A Radiative–Convective Equilibrium Perspective of Weakening of the Tropical Walker Circulation in Response to Global Warming
Authors: Huang Xianglei , Chuang Hui-Wen , Dessler Andrew , Chen Xiuhong , Minschwaner Kenneth , Ming Yi , Ramaswamy V. 
Published: September 2012

Abstract
Both observational analysis and GCM simulations indicate that the tropical Walker circulation is becoming weaker and may continue to weaken as a consequence of climate change. Here, the authors use a conceptual radiative–convective equilibrium (RCE) framework to interpret the weakening of the Walker circulation as simulated by the GFDL coupled GCM. Based on the modeled lapse rate and clear-sky cooling rate profiles, the RCE framework can directly compute the change of vertical velocity in the descending branch of the Walker circulation, which agrees with the counterpart simulated by the GFDL model. The results show that the vertical structure of clear-sky radiative cooling rate QR will change in response to the increased water vapor as the globe warms. The authors explain why the change of QR is positive in the uppermost part of the troposphere (&lt;300 hPa) and is negative for the rest of the troposphere. As a result, both the change of clear-sky cooling rate and the change of tropospheric lapse rate contribute to the weakening of circulation. The vertical velocity changes due to the two factors are comparable to each other from the top of the planetary boundary layer to 600 hPa. From 600 to 300 hPa lapse rate changes are the dominant cause of the weakening circulation. Above 300 hPa, the change due to QR is opposite to the change due to lapse rate, which forces a slight increase in vertical velocity that is seen in the model simulation.
Simulation of Northern Eurasian Local Snow Depth, Mass, and Density Using a Detailed Snowpack Model and Meteorological Reanalyses
Authors: Brun Eric , Vionnet Vincent , Boone Aaron , Decharme Bertrand , Peings Yannick , Valette Rémi , Karbou Fatima , Morin Samuel 
Published: September 2012

Abstract
The Crocus snowpack model within the Interactions between Soil–Biosphere–Atmosphere (ISBA) land surface model was run over northern Eurasia from 1979 to 1993, using forcing data extracted from hydrometeorological datasets and meteorological reanalyses. Simulated snow depth, snow water equivalent, and density over open fields were compared with local observations from over 1000 monitoring sites, available either once a day or three times per month. The best performance is obtained with European Centre for Medium-Range Weather Forecasts (ECMWF) Interim Re-Analysis (ERA-Interim). Provided blowing snow sublimation is taken into account, the simulations show a small bias and high correlations in terms of snow depth, snow water equivalent, and density. Local snow cover durations as well as the onset and vanishing dates of continuous snow cover are also well reproduced. A major result is that the overall performance of the simulations is very similar to the performance of existing gridded snow products, which, in contrast, assimilate local snow depth observations. Soil temperature at 20-cm depth is reasonably well simulated. The methodology developed in this study is an efficient way to evaluate different meteorological datasets, especially in terms of snow precipitation. It reveals that the temporal disaggregation of monthly precipitation in the hydrometeorological dataset from Princeton University significantly impacts the rain–snow partitioning, deteriorating the simulation of the onset of snow cover as well as snow depth throughout the cold season.
Using a Gridded Global Dataset to Characterize Regional Hydroclimate in Central Chile
Authors: Demaria E. M. C. , Maurer E. P. , Sheffield J. , Bustos E. , Poblete D. , Vicuña S. , Meza F. 
Published: September 2012

Abstract
Central Chile is facing dramatic projections of climate change, with a consensus for declining precipitation, negatively affecting hydropower generation and irrigated agriculture. Rising from sea level to 6000 m within a distance of 200 km, precipitation characterization is difficult because of a lack of long-term observations, especially at higher elevations. For understanding current mean and extreme conditions and recent hydroclimatological change, as well as to provide a baseline for downscaling climate model projections, a temporally and spatially complete dataset of daily meteorology is essential. The authors use a gridded global daily meteorological dataset at 0.25° resolution for the period 1948–2008, adjusted by monthly precipitation observations interpolated to the same grid using a cokriging method with elevation as a covariate. For validation, daily statistics of the adjusted gridded precipitation are compared to station observations. For further validation, a hydrology model is driven with the gridded 0.25° meteorology and streamflow statistics are compared with observed flow. The high elevation precipitation is validated by comparing the simulated snow extent to Moderate Resolution Imaging Spectroradiometer (MODIS) images. Results show that the daily meteorology with the adjusted precipitation can accurately capture the statistical properties of extreme events as well as the sequence of wet and dry events, with hydrological model results displaying reasonable agreement with observed streamflow and snow extent. This demonstrates the successful use of a global gridded data product in a relatively data-sparse region to capture hydroclimatological characteristics and extremes.
Unforced Oscillation of Rip-Current Vortex Cells
Authors: Geiman Joseph D. , Kirby James T. 
Published: September 2012

Abstract
A numerical simulation of a monochromatic surface gravity wave–driven flow over an alongshore quasi-periodic rip-channeled beach using the wave-resolving model Funwave is used to investigate coherent, very low-frequency (VLF) motions with characteristic frequencies f &lt; 4.0 mHz inside of the surf zone generated by wave breaking. These oscillations of the nearshore cellular vorticity pattern occur for shore-normal waves over a wide range of amplitudes of the incident wave field and occur despite the wave forcing being essentially constant. The oscillations occur at the lower end of the VLF spectrum or around fp = 0.55 mHz. For small incident wave amplitudes, an equilibrium state consisting of a staggered counterrotating vortex array generates a net weak alongshore current that is also seen in drifter trajectories observed in the field. Using a simpler pseudospectral vorticity model of a single dipole generated by a smooth, stationary in time forcing function sb, this study shows show that the Strouhal number of the vortex shedding process responsible for the oscillation is dependent on the circulation strength of the vortices in the dipole, as well as the bottom friction parameter. This process includes the pinching off, advection, and eventual regeneration of the vortex in the dipole. A simple scaling argument shows good agreement with the frequencies observed in the simulations.
Dynamics of Intensified Downwelling Circulation over a Widened Shelf in the Northeastern South China Sea
Authors: Gan Jianping , San Ho Ho , Liang Linlin 
Published: September 2012

Abstract
This study reveals the dynamics behind the intensified, downslope, cross-isobath transport over a widened shelf (narrowing downwave) in the northeastern South China Sea (NSCS) during a downwelling event. Utilizing a three-dimensional numerical model over an idealized NSCS shelf, this study identified the forcing process and derived an analytical understanding of the invoked dynamics for the intensified downslope cross-isobath transport. This study found that the transport was formed by an amplified geostrophic transport because of an increased positive along-isobath pressure gradient force (PGF), PY*, and by an enhanced bottom Ekman transport due to converging flow over the widened shelf. Based on the depth-integrated vorticity dynamics, PY* was linked with net frictional stress curl in the water column and the curl was primarily associated with the shear vorticity field induced by downwelling jet. The increased positive vorticity seaside of the jet provided positive PY* for the downslope geostrophic transport. The cross-isobath PGF, PX*, which was geostrophically formed and shaped by the spatially asymmetric isobaths of the widened shelf, determined the intensities of the jet and thus the associated shear vorticity that quantified the respective bottom friction transport and PY* for the intensified cross-isobath transport. It was found that the downslope transport over the widened shelf was strengthened in a stratified flow by the linked intensifications of barotropic PX* or the concurrent downwelling jet, shear vorticity field, PY*, and bottom friction because of an increase of volume flux upstream of the widened shelf.
Examining the Impact of Surface Currents on Satellite Scatterometer and Altimeter Ocean Winds
Authors: Plagge Amanda M. , Vandemark Douglas , Chapron Bertrand 
Published: September 2012

Abstract
A 5-yr dataset collected over two surface current and meteorological moorings allows rigorous evaluation of questions surrounding wave–current interaction and the scatterometer. Results demonstrate that scatterometer winds represent winds relative to the moving sea surface, affirming previous observational efforts that inferred the phenomenon using climatological approaches over larger time and space scales in equatorial and western boundary currents. Comparisons of wind residuals between Ku-band Quick Scatterometer (QuikSCAT) and buoy measurements show nearly one-to-one correlations with ocean surface velocity for 5-, 12.5-, and 25-km resolution wind speed products, especially under conditions of moderate wind speed and near-neutral atmospheric stability. Scatterometer and buoy wind direction differences due to currents were observed to be negligible for the range of surface velocities encountered and the length scales observed by QuikSCAT. Similar analyses are applied to C-band Advanced Scatterometer (ASCAT) satellite wind measurements at the same sites, as well as to satellite altimeter winds, and overall confirm the results seen with QuikSCAT; differences are likely the combined result of sampling, satellite wind algorithms, and geophysical wind–wave coupling in the presence of currents. On the whole, this study affirms that at length scales of 10 km and longer the scatterometer wind can be considered to be current relative. Observed differences between earth-relative and current-relative winds of order 10%–20% of the wind velocity are not uncommon in this and other ocean regions and this study more fully validates that microwave remote sensing winds appear to respond to wind stress even in the presence of larger-scale currents.
Prevalence, correlates and comorbidity of DSM-IV Cannabis Use and Cannabis Use Disorders in Australia
Authors: Teesson Maree , Slade Tim , Swift Wendy , Mills Katherine , Memedovic Sonja , Mewton Louise , Grove Rachel , Newton Nicola , Hall Wayne 
Published: September 2012

Objective: To report nationally representative findings on the prevalence, correlates, psychiatric comorbidity and treatment of DSM-IV Cannabis Use and Cannabis Use Disorders in Australia. Method: The 2007 National Survey of Mental Health and Wellbeing was a nationally representative household survey of 8841 Australians (16–85 years) that assessed symptoms of the most prevalent DSM-IV mental disorders. Results: Prevalence of lifetime and 12-month cannabis use was 18% and 6%; prevalence of lifetime and 12-month cannabis use disorder was 6% and 1%. The conditional prevalence (proportion of ever users who met criteria for a disorder) of lifetime and 12-month cannabis use disorder was 32.2% and 14.3%. Current cannabis use disorders were more common in males (OR 2.0) and younger users (OR 4.6). Strong associations were observed between current cannabis use disorders and alcohol use disorders (OR 3.6) and current affective disorders (OR 3.0). Only 36.2% of those with current cannabis use disorders sought any treatment. Conclusions: The prevalence of cannabis use disorders in the Australian population is comparable with that in the USA. Current cannabis use disorders are highly concentrated in young Australians who have high levels of comorbidity. The low rates of treatment seeking warrant attention in treatment and prevention strategies.
Perceived Impact of Cancer Treatment on Diabetes Self-Management
Authors: Hershey Denise Soltow , Tipton Janelle , Given Barbara , Davis Ellen 
Published: September 2012

Purpose The purpose of this study was to identify the impact that cancer and its treatment had on diabetes self-management and to identify common issues that individuals with diabetes encounter while undergoing chemotherapy. Methods This exploratory study utilized a baseline self-administered written survey and an 8-week telephone follow-up survey that included 2 open-ended questions. Forty-three adults aged 50 or older with diabetes and a solid tumor cancer receiving chemotherapy were recruited from 8 community outpatient cancer centers in Michigan and Ohio. Descriptives, t tests, and correlations were utilized to analyze the data. Content analysis was used to analyze the data from the open-ended questions. Results After a minimum of 8 weeks of chemotherapy, patients performed significantly fewer diabetes self-management behaviors. The majority of individuals experienced a moderate to high impact on their ability to perform diabetes self-management activities while receiving chemotherapy. Exercise, ability to eat and drink, and monitoring blood sugars were most affected. Three themes identifying patient issues were noted: self-management issues, health issues, and prioritization. Conclusions Cancer treatment and cancer-related symptoms can have a negative impact on diabetes self-management behaviors in adults with diabetes who are undergoing chemotherapy. Diabetes self-management education is targeted to improve health outcomes in patients with diabetes and cancer and addresses the “cause” not just the “source” of the problem needs to be developed. Further research needs to be done to address issues related to glycemic control and health-related outcomes in this population.
Remplissage Repair—New Frontiers in the Prevention of Recurrent Shoulder Instability
Authors: Franceschi Francesco , Papalia Rocco , Rizzello Giacomo , Franceschetti Edoardo , Del Buono Angelo , Panascì Manlio , Maffulli Nicola , Denaro Vincenzo 
Published: September 2012

Background: An engaging Hill-Sachs lesion is a defect of the humeral head, large enough to cause locking of the humeral head against the anterior corner of the glenoid rim when the arm is at 90° of abduction and more than 30° of external rotation. Hypothesis: When Bankart lesions are associated with engaging Hill-Sachs defects, simultaneous Bankart repair and remplissage provide lower recurrence rates than does Bankart repair alone. Study Design: Cohort study; Level of evidence, 3. Methods: Fifty patients (36 men, 14 women) with combined engaging Hill-Sachs and Bankart lesions were evaluated, before and after arthroscopic management, at a minimum follow-up of 2 years. After imaging and arthroscopic assessment, 25 patients underwent remplissage and Bankart repair, and 25 patients received Bankart repair alone. Patients were evaluated using the UCLA, Constant, and Rowe scores, and range of motion was measured using a goniometer. Postoperatively, all patients underwent magnetic resonance imaging to assess the status of healing of the anterior labrum and whether the tenodesis of the infraspinatus covered the Hill-Sachs defect. Results: At the last appointment, active forward elevation, external rotation beside the body, internal rotation, and all administered scores were significantly improved compared with baseline assessment, with no statistically significant intergroup differences. A new posttraumatic dislocation occurred in 5 patients, all from the Bankart-only group (20%). Conclusion: Remplissage is a safe, relatively short procedure that allows the surgeon to address large humeral defects with a low postoperative recurrence rate. Humeral head large defects predispose to recurrent instability of the shoulder and deserve surgical management.
Self-assembled photosensitizer-conjugated nanoparticles for targeted photodynamic therapy
Authors: Zhao Linlin , Kim Tae-Hyun , Huh Kang Moo , Kim Hae-Won , Kim So Yeon 
Published: September 2012

An effective tumor-targeted drug delivery system for photodynamic therapy was developed by designing ligand-mediated nanoparticles with stable formulations of a hydrophobic photosensitizer. Novel folic acid (FA)-conjugated amphiphilic block copolymers of polyethylene glycol (PEG) and poly-β-benzyl-L-aspartate (PBLA) with the potential to act as pH-responsive drug release reservoirs were synthesized. The photosensitizer, 2,4-diacetyl deuteroporphyrin IX dimethyl ether (DD-PpIX), was conjugated to the copolymers through pH-sensitive hydrazone linkage. The syntheses and compositions of all copolymers were confirmed by 1H NMR measurement. Photosensitizer-conjugated amphiphilic copolymeric nanoparticles (FA-PEG-P(Asp-Hyd)-DD-PpIX) were prepared by micelle formation in aqueous solution. The particle sizes of the FA-PEG-PBLA and FA-PEG-P(Asp-Hyd)-DD-PpIX nanoparticles were determined by light-scattering measurements. The range was 105–298 nm, depending on copolymer molecular weight and composition. Field emission scanning electron microscopy showed that the FA-PEG-P(Asp-Hyd)-DD-PpIX copolymeric nanoparticles were submicron in size and spherical in shape. The results of in vitro release tests showed that the release profiles of DD-PpIX from the nanoparticles were strongly pH-dependent and influenced by the amount of photosensitizer that was conjugated. In vitro tests using HeLa cells indicated that the FA-PEG-P(Asp-Hyd)-DD-PpIX nanoparticles had low dark-toxicity and showed more than 97% of cellular uptake. Based on our results, the FA-PEG-P(Asp-Hyd)-DD-PpIX nanoparticle system could be a promising approach for developing novel photosensitizer delivery carriers for photodynamic therapy.
Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1
Authors: Delehanty Lorrie L. , Bullock Grant C. , Goldfarb Adam N. 
Published: September 2012

Abstract
In red cell development, the differentiation program directed by the transcriptional regulator GATA1 requires signaling by the cytokine erythropoietin, but the mechanistic basis for this signaling requirement has remained unknown. Here we show that erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetylase 5 (HDAC5) dissociation from GATA1, and subsequent GATA1 acetylation. Mice deficient for HDAC5 show resistance to anemic challenge and altered marrow responsiveness to erythropoietin injections. In ex vivo studies, HDAC5−/− progenitors display enhanced entry into and passage through the erythroid lineage, as well as evidence of erythropoietin–independent differentiation. These results reveal a molecular pathway that contributes to cytokine regulation of hematopoietic differentiation and offer a potential mechanism for fine tuning of lineage-restricted transcription factors by lineage-specific cytokines.
Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease
Authors: Camus Stéphane M. , Gausserès Blandine , Bonnin Philippe , Loufrani Laurent , Grimaud Linda , Charue Dominique , De Moraes Joao A. , Renard Jean-Marie , Tedgui Alain , Boulanger Chantal M. , Tharaux Pierre-Louis , Blanc-Brude Olivier P. 
Published: September 2012

AbstractPatients with sickle cell disease suffer from painful crises associated with disseminated vaso-occlusions, increased circulating erythrocyte microparticles (MPs), and thrombospondin-1 (TSP1). MPs are submicron membrane vesicles shed by compromised or activated cells. We hypothesized that TSP1 mediates MP shedding and participates in vaso-occlusions. We injected TSP1 to transgenic SAD mice with sickle cell disease and characterized circulating phosphatidylserine+ MPs by FACS. TSP1 stimulated MPs in plasma and initiated vaso-occlusions within minutes. In vitro, TSP1 triggered rapid erythrocyte conversion into spicule-covered echinocytes, followed by MP shedding. MP shedding was recapitulated by peptides derived from the TSP1 carboxyterminus. We purified MPs shed by erythrocytes in vitro and administered them back to SAD mice. MPs triggered immediate renal vaso-occlusions. In vitro, MPs triggered the production of radical oxygen species by endothelial monolayers, favored erythrocyte adhesion, and induced endothelial apoptosis. MPs also compromised vasodilation in perfused microvessels. These effects were inhibited by saturating MP phosphatidylserine with annexin-V, or with inhibitors of endothelial ROS production. We conclude that TSP1 triggers erythrocyte MP shedding. These MPs induce endothelial injury and facilitate acute vaso-occlusive events in transgenic SAD mice. This work supports a novel concept that toxic erythrocyte MPs may connect sickle cell anemia to vascular disease.