bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitätssicherung in alternativen Wohnformen
Authors: Wolf-Ostermann Karin , Meyer Saskia , Worch Andreas , Gräske Johannes 
Published: March 2014

EinleitungDie Anzahl der Pflegebedürftigen steigt bei gleichzeitig abnehmendem familiärem Unterstützungspotenzial an. Die Frage nach Versorgungserfordernissen gewinnt an Bedeutung, alternative Wohn- und Betreuungsformen nehmen zahlenmäßig deutlich zu. Gleichzeitig fehlen bundesweit gültige Vorgaben zu Qualitätsvorgaben und Qualitätssicherungskonzepten sowie einheitliche Begriffsdefinitionen zur klaren Abgrenzung zwischen den verschiedenen alternativen Wohnformen. Wünschenswert wären wissenschaftlich abgesicherte Qualitäts(weiter)entwicklungskonzepte für alternative Wohnformen.
Qualität von Gesundheitsinformationen
Authors: Koch Klaus 
Published: March 2014

Einleitung
Wer einen Eindruck von der Welt der Gesundheitsinformation haben will, muss nur einen passenden Begriff in eine Internet-Suchmaschine eingeben. „Bluthochdruck“ beispielsweise liefert bei Google über 1,4 Millionen Treffer. Darunter gibt es alles: Von hochwertigen Informationen über getarnte Produktwerbung bis hin zur Scharlatanerie. Qualitätsinitiativen haben es da nicht leicht. In den letzten Jahren aber international und national einige Initiativen entstanden, denen es gelingen könnte, so etwas wie eine kritische Masse „guter“ Gesundheitsinformationen entstehen zu lassen.
Gesetzliche Qualitätssicherung in der medizinischen Versorgung: Stand und Weiterentwicklung – Sektorenübergreifende Qualitätssicherung nach § 137a SGB V
Authors: Bramesfeld Anke , Willms Gerald 
Published: March 2014

Einleitung
Seit dem Jahr 2000 sind die Leistungserbringer im Gesundheitswesen zur einrichtungsübergreifenden Qualitätssicherung (QS) gesetzlich verpflichtet. Gegenwärtig ist dies ausschließlich in der stationären Versorgung implementiert. Seit 2009 besteht der gesetzliche Auftrag QS sektorenübergreifend auszurichten. Die Weiterentwicklung der QS erfolgt derzeit in fünf Bereichen: 1. Entwickeln sektorenübergreifender QS, 2. Nutzen von Routinedaten, 3. Berücksichtigen der Patientenperspektive, 4. Einführen von Follow-ups, 5. Ermöglichen eines fairen Leistungserbringervergleichs.
Die Qualität der Qualität: Parallelwelten der Versorgungsqualität und des Qualitätsmanagements
Authors: Iseringhausen Olaf 
Published: March 2014

Einleitung
Die Entwicklung qualitätsverbessernder Verfahren im Gesundheitswesen ist zu einer von Experten verwalteten Branche geworden. Die Anzahl von Verfahren, die die Qualität in der ambulanten und stationären Versorgung steigern sollen, ist inzwischen unübersichtlich groß. Kaum jemand kann überblicken, wer was unter Qualität versteht, mit welchem Ziel Qualität gemessen werden soll und wie sie verbessert werden kann. In dem Beitrag wird danach gefragt, inwieweit mit diesen Verfahren tatsächlich ein Patientennutzen erzielt wird.
Qualitätssicherung in der Rehabilitation
Authors: Jäckel Wilfried H. , Farin Erik 
Published: March 2014

Einleitung
In den letzten zwei Dekaden sind durch die Einführung wissenschaftlich fundierter, umfassender und patientenzentrierter Qualitätssicherungsprogramme sowie durch die Verpflichtung zum Nachweis von Zertifikaten im Bereich des Qualitätsmanagements erhebliche Anstrengungen zur Steigerung der Qualität in der Rehabilitation sowohl im Bereich der Gesetzlichen Rentenversicherung als auch der Gesetzlichen Krankenversicherung unternommen worden.
A case of ecological specialization in ladybirds:Iberorhyzobius rondensis(Coleoptera: Coccinellidae), potential biocontrol agent ofMatsucoccus feytaudi(Hemiptera: Matsucoccidae)
Authors: Tavares C. , Jactel H. , van Halder I. , Mendel Z. , Branco M. 
Published: March 2014

AbstractSpecialization is an important attribute of a biological control agent. The maritime pine bast scale,Matsucoccus feytaudiDucasse (Hemiptera Matsucoccidae), is an invasive species in Southeast France and the North of Italy.Iberorhyzobius rondensisEizaguirre (Coleoptera: Coccinellidae), is a recently described ladybird species. Both adults and larvae are predaceous, feeding on egg masses ofM. feytaudi, and are strongly attracted toM. feytaudi’s sex pheromone. To evaluate the potential ofI. rondensisas a biocontrol agent of the scale, we studied its niche breadth and prey range with emphasis on pine forests and hemipterans as tested prey. In this study,I. rondensiswas found to achieve complete development only when fed onM. feytaudiegg masses (92.9% survival) and an artificial prey: eggs ofEphestia kuehniellaZeller (27.6% survival). From the 2nd instar onwards, complete development could be achieved using other prey species, although larvae had significantly higher mortality and slower development. In choice tests,M. feytaudiwas the preferred prey. Surveys of the ladybird populations in the Iberian Peninsula revealed that it was found exclusively onPinus pinasterAiton, the sole host ofM. feytaudi. The unusual specialization ofI. rondensis, among other predaceous ladybirds, makes it an appropriate candidate for classical biological control ofM. feytaudi.
Estimating the impact of somatic cell count on the value of milk utilising parameters obtained from the published literature
Authors: Geary Una , Lopez-Villalobos Nicolas , O'Brien Bernadette , Garrick Dorian J , Shalloo Laurence 
Published: March 2014

The impact of mastitis on milk value per litre independent of the effect of mastitis on milk volume, was quantified for Ireland using a meta-analysis and a processing sector model. Changes in raw milk composition, cheese processing and composition associated with increased bulk milk somatic cell count (BMSCC) were incorporated into the model. Processing costs and market values were representative of current industry values. It was assumed that as BMSCC increased (i) milk fat and milk protein increased and milk lactose decreased, (ii) fat and protein recoveries decreased, (iii) cheese protein decreased and cheese moisture increased. Five BMSCC categories were examined from ⩽100 000 to >400 000 cells/ml. The analysis showed that as BMSCC increased the production quantities reduced. An increase in BMSCC from 100 000 to >400 000 cells/ml saw a reduction in net revenue of 3·2% per annum (€51·3 million) which corresponded to a reduction in the value of raw milk of €0·0096 cents/l.
He, Who Has Sown the Wind: Karakhan, the Sino-Soviet conflict over the Chinese Eastern Railway, 1925–26, and the failure of Soviet policy in northeast China
Authors: VUL NIKITA 
Published: March 2014

AbstractThis article deals with the Sino–Soviet conflict of 1925–26 over the Chinese Eastern Railway, with special attention given to its background and consequences. In 1924, the Chinese Eastern Railway became a joint venture between the Soviet Union and China, creating fresh friction between the joint Soviet and Chinese managers which culminated in general manager A.N. Ivanov's prohibition on transporting military cargoes and troops, and Ivanov's arrest by Manchurian warlord-general Zhang Zuolin. Some scholars and diplomatists have viewed Ivanov's prohibition and the simultaneous rebellion by Chinese general Guo Songling against Zhang as a Soviet attempt to replace Zhang with a more manageable warlord. But this article argues that although the prohibition—a typical instance of back-and-forth Soviet diplomacy—was a coincidence, it was primarily the result of Soviet ambassador Lev M. Karakhan's tough stance and his rash decision-making, undertaken without seeking advice from Moscow. Zhang's victory in the 1926 clash convinced the Chinese that they had the power to take repressive measures against the Soviet Union's citizens and institutions, which led to the Sino–Soviet conflict of 1929 and exacerbated Japanese alarm over the Soviet's increasing strength in the region. This was to be a factor in the takeover of Manchuria in 1931 by Japan's Guandong Army, which eventually led to global war. This article, therefore, deals with the origins of world-changing events and thus is interesting to Modern Asian Studies’ wider readership.
Alfred de Quervain's Swiss Greenland expeditions, 1909 and 1912
Authors: Barr William 
Published: March 2014

ABSTRACTIn 1909, with two companions Swiss meteorologist Alfred de Quervain travelled to the Uummannaq area of west Greenland, to the same area investigated by Erich von Drygalski in 1892–1893. A major objective was to investigate the changes in the nearby outlet glaciers since Drygalski's visit. Man-hauling sledges, de Quervain and his companions also made a sortie into the interior of the ice cap, penetrating to a distance of about 100 km and to a height of about 1700 m. Having thus whetted his appetite, in1912 de Qervain mounted a further expedition aimed at making a crossing of the ice cap, only the second after that of Fridtjof Nansen in 1888, and along a trajectory significantly further north. De Quervain hoped to determine the shape and height of the ice cap along this trajectory. With three companions and using dog-sledges de Quervain set off from the Disko Bugt area of west Greenland and crossed the ice cap to the area of Ammassalik (now Tasiilaq) on the east coast. In 31 days on the ice the party travelled some 640 km, reaching a maximum altitude of 2510 m. A comprehensive range of scientific observations was effected en route. A support party of three men remained at the western edge of the ice cap for the summer to conduct meteorological and glaciological studies. Thereafter two of this group spent the winter of 1912–1913 at the Danish Arctic Station at Godhavn as guests of Morten Porsild to conduct aerological studies using pilot balloons and, to a lesser degree, captive balloons. All quotations in this paper are translated from the German by the author. This article is the first English-language account of de Quervain's expeditions.
Schizophrenia and violent crime: a population-based study
Authors: Fleischman A. , Werbeloff N. , Yoffe R. , Davidson M. , Weiser M. 
Published: March 2014

BackgroundPrevious studies have found that patients with schizophrenia are more likely to be violent than the general population. The aim of this study was to investigate the association between schizophrenia and violent crime in the Israeli population.MethodUsing the Israeli Psychiatric Hospitalization Case Registry we identified 3187 patients with a discharge diagnosis of schizophrenia. For each proband we identified parents and siblings, and gender- and age-matched controls for patients, parents and siblings. Information on violent crimes was obtained from police records.ResultsPatients with schizophrenia were at increased risk for violent crimes compared with controls [odds ratio (OR) 4.3, 95% confidence interval (CI) 3.8–4.9], especially women (OR 9.9, 95% CI 6.2–15.7). Risk for violent crimes was higher among patients with co-morbid substance misuse than in patients without such co-morbidity (OR 5.1, 95% CI 4.2–6.3).ConclusionsThe results of this study suggest that increased risk of violence is part of the clinical picture of schizophrenia and needs to be recognized as a legitimate, essential, aspect of clinical management.
Cosmopolitanism and the culture of peacebuilding
Authors: GOETZE CATHERINE , de GUEVARA BERIT BLIESEMANN 
Published: March 2014

AbstractCosmopolitanism has been argued to be a crucial component of peacebuilding, both with regard to its aims as well as its staff. In a universalist-liberal understanding of the concept, cosmopolitanism is the optimal mind frame for peacebuilders to rebuild post-war societies, due to the tolerance, justice-orientation, and neutrality regarding local cleavages that the concept entails in theory. This article argues, however, that cosmopolitanism cannot be understood outside of its social context, therefore requiring sociological empirical analyses. Drawing on three such sociological concepts, namely elite, glocal, and localisable cosmopolitanism, the article analyses empirically through interviews with peacebuilders in Kosovo whether and in which form these international civil servants display cosmopolitan worldviews. The study concludes that while in theory the localisable variant would be best suited to contribute to locally sensitive, emancipatory peacebuilding, this form of cosmopolitanism is absent in practice. Given the novel, exploratory character of this analysis of hitherto uncharted terrain, the article also discusses in detail how the findings were obtained and in how far they are generalisable.
Three soil chronosequences in recessional glacial deposits near the polar plateau, in the Central Transantarctic Mountains, Antarctica
Authors: Scarrow Joshua W. , Balks Megan R. , Almond Peter C. 
Published: March 2014

AbstractSoil chronosequences in till deposits emplaced during glacial retreat in the Central Transantarctic Mountains are described. Discrepancies between the degree of soil development and reported cosmogenic surface exposure ages suggest slower, weaker soil development in this region than encountered in other areas of Antarctica. The study sites (Dominion Range, Mount Achernar and Ong Valley) were located between 83° and 85°S, at altitudes of 1600–2200 m, on the edge of the polar plateau. Soil landscape maps show a gradation of soil properties across landscape units that were designated as homogenous/single-event drifts in previous smaller-scale studies. Along transects away from the current ice edge, the depth to underlying ice thickened (from 2 cm to > 80 cm), soil became more weathered, saltier and less alkaline, and horizonation became more pronounced. Soil thickness, clast abundance and soil chemistry are all consistent with a two-layer mode of soil formation. We suggest that a thin, clast-rich surface horizon, originating from weathering of supraglacial debris, overlies a thick, clast-poor sublimation till. The supraglacial debris has a finite contribution to soil volume, whereas sublimation offers an ongoing source of soil material that thickens the soil from its base.
Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits
Authors: Sugimoto Hironobu , Kida Yuta , Oh Noriyoshi , Kitada Kensaku , Matsumoto Kazuya , Saeki Kazuhiro , Taniguchi Takeshi , Hosoi Yoshihiko 
Published: March 2014

SummaryWe examined growing oocytes collected from follicles remaining in superovulated rabbit ovaries, that were grown (in vitro growth, IVG) and matured (in vitro maturation, IVM) in vitro. We produced somatic cell nuclear transfer (SCNT) embryos using the mature oocytes and examined whether these embryos have the ability to develop to the blastocyst stage. In addition, we examined the effects of trichostatin A (TSA), a histone deacetylase inhibitor (HDACi), on the developmental competence of SCNT embryos derived from IVG–IVM oocytes. After growth for 7 days and maturation for 14–16 h in vitro, the growing oocytes reached the metaphase II stage (51.4%). After SCNT, these reconstructed embryos reached the blastocyst stage (20%). Furthermore, the rate of development to the blastocyst stage and the number of cells in the blastocysts in SCNT embryos derived from IVG–IVM oocytes were significantly higher for TSA-treated embryos compared with TSA-untreated embryos (40.6 versus 21.4% and 353.1 ± 59.1 versus 202.5 ± 54.6, P < 0.05). These results indicate that rabbit SCNT embryos using IVG–IVM oocytes have the developmental competence to reach the blastocyst stage.
Tetralogy of Fallot with coarctation of the aorta: a newly recognised developmental and anatomic syndrome
Authors: Perdreau Elodie , Houyel Lucile , Baruteau Alban-Elouen 
Published: March 2014

AbstractTetralogy of Fallot and coarctation of the aorta is an exceptional association. We report here four cases of infants referred for tetralogy of Fallot with or without pulmonary atresia associated with aortic coarctation from 1974 to 2013. All had a right aortic arch, and the coarctation was abnormally situated between the right common carotid and the right subclavian arteries. In all, two infants had an abnormal left subclavian artery and one child had DiGeorge syndrome. All underwent staged surgical repair of the left and right-sided obstructions. A review of the literature shows two types of coarctation in this context. In left aortic arch, coarctation is situated distal to the left subclavian artery. In right aortic arch, coarctation is distal to the right common carotid artery, mirror-image of interrupted left aortic arch type B, associated with anomalies of the branches of the aorta, and should be considered a complex anomaly of aortic arches in the setting of an outflow tract defect due to abnormal migration of cardiac neural crest cells. Screening for this unusual association is critical in the initial assessment of all patients with tetralogy of Fallot.
Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction
Authors: Brantley SJ , Gufford BT , Dua R , Fediuk DJ , Graf TN , Scarlett YV , Frederick KS , Fisher MB , Oberlies NH , Paine MF 
Published: March 2014

Herb–drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction accuracy of potential herb–drug interactions using the semipurified milk thistle preparation, silibinin, as an exemplar herbal product. Interactions between silibinin constituents and the probe substrates warfarin (CYP2C9) and midazolam (CYP3A) were simulated. A low silibinin dose (160 mg/day × 14 days) was predicted to increase midazolam area under the curve (AUC) by 1%, which was corroborated with external data; a higher dose (1,650 mg/day × 7 days) was predicted to increase midazolam and (S)‐warfarin AUC by 5% and 4%, respectively. A proof‐of‐concept clinical study confirmed minimal interaction between high‐dose silibinin and both midazolam and (S)‐warfarin (9 and 13% increase in AUC, respectively). Unexpectedly, (R)‐warfarin AUC decreased (by 15%), but this is unlikely to be clinically important. Application of this PBPK modeling framework to other herb–drug interactions could facilitate development of guidelines for quantitative prediction of clinically relevant interactions.CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e107; doi: 10.1038/psp.2013.69; advance online publication 26 March 2014
Classroom-Based Narrative and Vocabulary Instruction: Results of an Early-Stage, Nonrandomized Comparison Study
Authors: Gillam Sandra Laing , Olszewski Abbie , Fargo Jamison , Gillam Ronald B. 
Published: March 2014

Purpose
This nonrandomized feasibility study was designed to provide a preliminary assessment of the impact of a narrative and vocabulary instruction program provided by a speech-language pathologist (SLP) in a regular classroom setting.

Method
Forty-three children attending 2 first-grade classrooms participated in the study. Children in each classroom were divided into high- and low-risk subgroups on the basis of their performance on a narrative test. Narrative and vocabulary instruction was provided by an SLP in 1 classroom for three 30-min periods per week for 6 weeks.

Results
The children in the experimental classroom made clinically significant improvements on narrative and vocabulary measures; children in the comparison classroom did not. Within the experimental classroom, children in the high-risk subgroup demonstrated greater gains in narration and fewer gains in vocabulary than children in the low-risk subgroup. There were no subgroup differences in the comparison classroom.

Conclusion
These preliminary results provide early evidence of the feasibility of implementing a narrative instruction program in a classroom setting. Children at a high risk for language difficulties appeared to profit more from the narrative instruction than from the embedded vocabulary instruction. More extensive research on this instructional program is warranted.

Supplemental Material

https://doi.org/10.23641/asha.6170276
Toy Talk: Simple Strategies to Create Richer Grammatical Input
Authors: Hadley Pamela A. , Walsh Kathleen M. 
Published: March 2014

Purpose
The purpose of this initial feasibility study was to determine whether brief instruction in toy talk would change grammatical properties of adult language, specifically 3rd person lexical noun phrase (NP) subjects.

Method

Eighteen college students participated in the study. The use of 3rd person subjects was examined before and after instruction on toy talk strategies (i.e.,
talk about the toys, give the item its name
). Change in the input informativeness for tense (i.e., the proportion of verb forms marked for tense out of all verb forms) was also examined, although adults were not instructed on use of tense/agreement morphemes.

Results

Following instruction, statistically significant increases with large effect sizes were observed for use of 3rd person subjects, lexical NP subjects, and input informativeness for tense (Cohen's
d
= 1.20, 2.08, and 0.89, respectively).

Conclusions
These findings demonstrate that young adults can learn these simple strategies with relatively brief instruction, and the use of toy talk also changes the richness of tense/agreement marking in adult language input. Considerations for incorporating toy talk into existing language modeling practices and future plans for evaluating the efficacy of toy talk are discussed.
Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis
Authors: Ridderstad Wollberg Anna , Ericsson-Dahlstrand Anders , Juréus Anders , Ekerot Petra , Simon Sylvia , Nilsson Maria , Wiklund Stig-Johan , Berg Anna-Lena , Ferm Mats , Sunnemark Dan , Johansson Rolf 
Published: March 2014

SignificanceMultiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS) causing paralysis. The most effective treatments for MS aim to block infiltration of inflammatory cells to the brain. However, severe side effects related to the broad-acting specificity of these treatments exist. AZD8797, a unique inhibitor of the chemokine receptor CX3CR1, provides inhibition of subpopulations of peripheral leukocytes with potential for a beneficial effect: side effect ratio. We provide evidence that blocking this receptor results in reduced paralysis, inflammation, and degeneration in the CNS in a disease model for MS. Furthermore, CX3CR1 expression analysis in the MS brain strengthens the evidence for CX3CR1 as a new target for the treatment of MS.
Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression
Authors: Korasick David A. , Westfall Corey S. , Lee Soon Goo , Nanao Max H. , Dumas Renaud , Hagen Gretchen , Guilfoyle Thomas J. , Jez Joseph M. , Strader Lucia C. 
Published: March 2014

SignificanceAuxin is a critical plant hormone that regulates every aspect of plant growth and development. AUXIN RESPONSE FACTOR (ARF) transcription factors control auxin-regulated gene transcription, and their activity is regulated by AUXIN/INDOLE 3-ACETIC ACID repressor proteins. This work identifies that dimerization of the repressor with the transcription factor is insufficient to repress activity, suggesting that multimerization is the mechanism of repressing ARF transcriptional activity and further raising the possibility that multimerization in other systems may play roles in transcriptional repression.