bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of intravitreal bevacizumab in the treatment of diabetic macular oedema
Authors: MALYSKO K , KUOLIENE K , CIMBALAS A , ASOKLIS R 
Published: August 2014

AbstractPurpose to evaluate the efficacy and safety of 1.25 mg intravitreal bevacizumab (IVB) in the treatment of diabetic macular oedema at Vilnius University Hospital Santariskiu Klinikos, Centre of Eye Diseases from July, 2012 to May, 2014.Methods Clinical data (best corrected visual acuity (BCVA) and OCT findings at baseline and at the end of the follow‐up) of 52 patients (76 eyes) were reviewed retrospectively. Patients who received only one intravitreal bevacizumab injection or whose medical data were missing were excluded.Results 76 eyes were treated with 1.25 mg intravitreal bevacizumab every 4 weeks at least with two injections for one eye and then continued if needed. The mean BCVA in patients with diabetic macular oedema at baseline (Snellen) was 0.31 (SD ±0.24). The mean number of intravitreal bevacizumab injections per eye was ‐ 3 (range 2‐8). Patients were observed for an average of 36 weeks. At the end of the follow‐up the mean BCVA increased to 0.4 (SD±0.31) and the central macular thickness detected on OCT decreased significantly (mean 325 (SD±228ϻm)). Four patients with resistant diabetic macular oedema underwent combined IVB and laser treatment. One case of endophthalmitis was observed.Conclusion Intravitreal bevacizumab seems to be effective and safe in the management of diabetic macular oedema in this short term retrospective study.
Detecting recurrence of macular edema in patients with wet AMD after anti‐VEGF treatment using 3D‐CTAG test
Authors: MILYUTKINA S , FINK W , KOVALEVSKAYA M 
Published: August 2014

AbstractPurpose To detect recurrence of macular edema inwet AMD patients after anti‐VEGF treatment using 3D‐Computer‐automated Threshold Amsler Grid testing (3D‐CTAG; Fink &Sadun, 2004).Methods Wet AMD patients (n=10, 11 eyes) 6 months after 3 injections of Ranibizumab (Lucentis, Novartis). Group #1(n=5, 6 eyes): norecurrence. Group #2 (n=5, 5 eyes): recurrence confirmed by OCT. Indices: # of VF defects per eye (ND); lowest perceivable contrast level (CL); VF volume lost relative to hill‐of‐vision (VLRH); lost area grade (LAG): [scotoma area at lowest tested contrast sensitivity level/scotoma area at highest tested contrast sensitivity level]×scotoma depth (%).Results Group #1:Visus=0,43±0,18logMAR; ND=0,67±1,2; CL=10±7,04%; VLRH=2,1±3,97%; LAG=150,92±341,35%. Group #2:Visus=0,51±0,49logMAR; ND=1,4±0,55; CL=38,8±12,03%; VLRH=15,18±10,56%; LAG=32,13±20,13%.Conclusion In group #2 3D‐CTAG revealed scotomas typical for macular edema: VLRH=15,18±10,56% compared to 2,1±3,97% (p=0,05) in group #1 and LAG=32,13±20,13% compared to 150,92±341,35% (p=0,05) in group #1. Observed functional disorders show that 3‐fold injection of Ranibizumab, adopted as the standard, appears to be insufficient in 45,45% of the cases. 3D‐CTAG may be an effective method for self‐monitoring the recurrence of macular edema in wet AMD patients.
Commercial interest
Cost of complications for patients with non‐infectious non‐anterior uveitis
Authors: TUNDIA N , SKUP M , OYE B , OKALIBE X , CHAO J , BAO Y , DICK A 
Published: August 2014

AbstractPurpose To estimate costs associated with eye‐related complications in non‐anterior non‐infectious uveitis (NIU).Methods Cases were ≥18 years old, had ≥2 diagnoses for non‐anterior (intermediate, posterior, or pan) NIU (Truven Health, 1/1/2000−12/31/2010), and developed complications (glaucoma, cataracts, visual disturbance, blindness, retinal detachment, cystoid macular degeneration). Cases and controls (NIU patients without complications) were matched 1:1 by uveitis type, sex, age, region, index date, and enrollment and followed for 1 year post complication. Annual mean total costs differences (medical and drugs) post complication were compared (ANCOVA).Results Annual total cost difference for any complication was significantly greater in patients with non‐anterior‐NIU overall ($7,596, N=1,327), posterior‐NIU (N=1,246, $7,117), and pan‐NIU ($24,595, N=27) vs controls (all P<.05); medical costs contributed more than drug costs. Annual mean total costs for visual disturbances, cataracts, and glaucoma combined were greater for non‐anterior‐NIU overall, posterior‐NIU, and pan‐NIU vs controls by $23,915, $23,182, and $50,213, respectively. Overall, the 1‐year post‐complication total cost burden was greater by $10,079,892 in non‐anterior NIU patients who developed complications vs controls.Conclusion This medical claims analysis revealed a significant economic burden due to complications of non‐anterior NIU.
Commercial interest
Transient branch retinal artery occlusion as the first microvascular sing of systemic lupus erythematosus
Authors: PAWLOWSKI P , ZINCZUK M , PAWLOWSKA M , RESZEC J 
Published: August 2014

AbstractPurpose To report a case of transient branch retinal artery occlusion (transient BRAO) in the course of lupus erythematosus preceding other systemic vascular complications.Methods Detailed ophthalmological examination including fluorescent angiography, SOCT and mfERG was performed. Laboratory test including morphology, antinuclear antibodies (ANA), antiphospholipid antibodies (APLA) were obtained. The patient was followed‐up for six months and one and three years after.Results An 29‐year‐old woman was presented with the reduced best corrected visual acuity (BCVA) (Vos= 0.1), and the acute retinal ischaemic lesion. Laboratory tests and the history of thrombocytopenia indicated the systemic lupus erythematosus. 6 months later the mean BCVA improved from 0,1 to 0,9. The scotoma observed in her central visual field had been reduced. Multifocal ERG (Espion E2, Diagnosys LLC, USA) demonstrated the impaired retinal function and spectral domain optical tomography (Nidek RS‐3000, Japan) revealed the macular thinning in the area of BRAO. Before the three‐year‐follow‐up patient had been referred to kindney biopsy were the advanced lupus nephritis was diagnosed, and had been operated due to aortic aneurysm.Conclusion The retinal vascular occlusion disorders in systemic lupus erythematosus may be the rare cause of transient BRAO in young patients and precede other systemic vascular complications.
Changes in choroidal thickness and corneal parameters in diabetic eyes
Authors: NORVYDAITE D , LAURINAVICIUTE G , STECH S , SKVARCIANY I , GALGAUSKAS S , ASOKLIS R 
Published: August 2014

AbstractPurpose To evaluate the effect of diabetes mellitus on the central corneal thickness (CCT), corneal endothelial parameters (endothelial cell density (ECD), their average size (Ave), hexagonality (A6), polymegathism (CV)) and the subfoveal choroidal thickness (SFCT). To determine whether these parameters depend on the duration of diabetes and haemoglobinA1c (HbA1c) level.Methods 62 diabetic patients and 65 healthy subjects were examined using a non‐contact specular microscope, A‐scan ultrasound and spectral domain optical coherence tomography. The study parameters included medical history, age, axial length, SFCT, CCT, ECD, A6, CV, Ave. The duration of diabetes and HbA1 level of 2 latest tests (6 months period) were noted.Results There was equal proportion of men and women 31(50%) in the diabetes group (62 patients, 124 eyes). The mean age was 45.5(±13.4) years, duration of diabetes – 9.3(±6.6) years, HbA1c level – 9.8(±2.3)%. Diabetic retinopathy (DR) was present in 22(17.9%) eyes, macular edema ‐ 10(8.1%). There were no differences in age, gender or axial length between the groups (p>0.05). SFCT (258.0±74.4µm) and ECD (2721.8±264.1cell/mm2) were significantly lower, CCT (566.7±35.7µm) ‐ higher in diabetic patients than in control group (313.1±88.5µm, 2967.3±220.6cell/mm2, 550.0±56.4µm) (p<0.05). DR and macular edema didn’t influence SFCT significantly (p>0.05). No differences in endothelial parameters between groups and no correlations between HbA1c, duration of diabetes and any of the examined parameters were found (p>0.05).Conclusion Diabetic patients have thicker corneas, lower endothelial cell density and thinner subfoveal choroid than healthy subjects.
Scleral collagen crosslinking (SXL) by riboflavin and blue light inhibits eye growth of young rabbits
Authors: KORBER N , GOHLER C , KOCH C , KARL A , PENK A , HUSTER D , REICHENBACH A , FRANCKE M , WIEDEMANN P , ISELI HP 
Published: August 2014

AbstractPurpose The application of riboflavin and blue light (for Collagen Crosslinking of scleral tissue; SXL) was proved as a possible therapeutic method to increase scleral stiffness and therefore, to inhibit eye growth in young rabbits.Methods For eye growth examination the sclera of young rabbit eyes were treated with riboflavin and 10 mW/cm² blue light. MR‐Imaging and ultrasonic A scans were used to measure effects of SXL treatment on eye growth. Safety and efficacy parameters were determined using immunohistochemical and histological methods.Results Immunohistochemical and histological examinations showed no neurodegenerative side effects or signs of glial reactivity in retinal tissue beyond a light intensity of 400 mW/cm². Young animals treated with a minimal effective light energy dose of 10 mW/cm² displayed a significant reduction of their eye growth. The eye growth inhibition after SXL treatment maintained for at least 24 weeks.Conclusion The results confirm the idea that scleral collagen crosslinking by riboflavin/blue light is an applicable method to inhibit eye growth and therefore, it might be a treatment for pathologic myopia.
Influence of pterygium excision surgery on corneal biomechanical properties
Authors: CARAMELLO C , MATEO OROBIA AJ , PÉREZ D , IBAÑEZ J , HERRERA L , ZABADANI K , MARTINEZ M , DEL BUEY MA , PINILLA I , ASCASO J 
Published: August 2014

AbstractPurpose To evaluate biomechanical corneal changes after pterygium excision surgery.Methods Prospective, interventional study in which 22 patients with unilateral pterygium were enrolled. Patients underwent pterigyum excision surgery with conjunctival autograft transplantation. The following corneal biomechanical properties were studied using Ocular Response Analyzer (ORA), preoperatively and postoperatively: Corneal Resistance Factor (CFR), Corneal Hysteresis (CH), Goldman correlated intraolcular pressure (IOPg) and Corneal Compensated IOP (IOPcc).Results CRF increased after pterygium excision surgery. Nevertheless, CRF returned to normal values at day 30. There was a decrease in CH parameters at day 7 and at day 30 compared with preoperative values. There was an increase in IOP, IOPg and IOPcc postoperatively.Conclusion CH decreases after pterygium surgery probably because of the elimination of a biomechanical reinforcement provided by the fibrovascular tissue that invades the anterior stroma. The postoperative decrease in CH could influence the IOP measure, which could be infraestimated using the Golman applanation technique. ORA postoperavtive exploration provides more precise IOP values.
Engineering the corneal stroma: The effect of a three‐dimensional environment and growth factor supplementation on keratocyte phenotype
Authors: SIDNEY LE , DUNPHY SE , ROSE FRAJ , HOPKINSON A 
Published: August 2014

AbstractPurpose A major challenge of producing a tissue‐engineered cornea is the recapitulation of the complex environment of the stroma. The resident cells of the stroma are keratocytes; a quiescent, dendritic cell type, responsible for maintaining the extracellular matrix. Upon injury, or during in vitro culture in foetal bovine serum (FBS), keratocytes differentiate into a fibroblastic repair phenotype. Differentiating these fibroblasts back to keratocytes is crucial in stromal tissue‐engineering. Methods previously suggested are three‐dimensional environments and serum‐free medium.Methods Primary human corneal stromal cells (CSC) were cultured to achieve a fibroblastic cell type reminiscent of a mesenchymal stem cell. CSC were seeded in poly(lactic‐co‐glycolic acid) (PLGA) microfibre scaffolds. Constructs were maintained under 4 media conditions: 20% FBS; 2% FBS; insulin‐transferrin‐selenium supplementation (ITS); and bFGF and TGF‐β3 supplementation (GF). Proliferation, cell phenotype, gene expression and matrix production were assessed.Results Scaffolds supported cell adhesion and proliferation in all media types. Gene expression and immunocytochemistry showed that scaffolds in ITS and GF media promote the keratocyte phenotype, with increased expression of CD34 and ALDH3A1. Collagen‐I deposition was seen to the greatest extent in GF cultures. Quantitative analysis showed expression of proteoglycans was greatest in GFConclusion PLGA microfibre scaffolds allow infiltration of CSCs and promote a keratocyte phenotype. This effect is augmented with the use of serum‐free medium and growth factor supplementation, leading to improved ECM production and deposition.
Bromfenac 0.09% BID after Nd:YAG laser posterior capsulotomy: evaluation of visual acuity and macular retinal thickness.
Authors: LOMBARDO S , TINELLI C , ANTONIAZZI ER 
Published: August 2014

AbstractPurpose To investigate the clinical outcomes of Bromfenac ophthalmic solution 0.09% dosed twice daily (BID) for 2 weeks following Neodymium:YAG (Nd:YAG) laser posterior capsulotomy in terms of best‐corrected visual acuity (BCVA) and macular retinal thickness.Methods 35 eyes with posterior capsular opacification were recruited, treated with Nd:YAG laser capsulotomy and subsequently with Bromfenac 0.09% BID for 2 weeks. Eyes with pre‐existing macular pathology were excluded. BCVA, a complete ophthalmologic assessment, macular scans by spectral domain optical coherence tomography (SD‐OCT Cirrus, Zeiss) were performed before YAG laser and after 2 weeks.Results Post‐operative BCVA at 2 weeks was significantly better than pre‐operative one (p<0.001). Likewise post‐operative signal strength (SS) of OCT images improved (p<0.001). There were no statistically significant differences between pre‐ and post‐operative macular retinal thickness. After multivariate analysis controlling for potential confounders (age, sex, total energy, SS), a significant decrease in macular thickness was shown in superior and nasal sectors (p<0.5).Conclusion Nd:YAG capsulotomy results in a measurable improvement in BCVA and in SS, allowing a more reliable examination of the posterior segment. It is also a safe procedure, resulting in no change in macular thickness. Bromfenac BID is effective for reducing ocular inflammation associated to laser surgery and for preventing the related complications (first of all macular cystoid edema). From a multivariate analysis Bromfenac even seems to determine a decreased macular thickness in some areas, due to a therapeutic efficacy and perhaps to an easier dosage with increased compliance.
Clinical outcomes after implantation of multifocal toric intra ocular lenses.
Authors: THOUVENIN R , ABRIEU M , BERGUIGA M , RAMBAUD C , CHENY T , SENDON D , FROUSSART‐MAILLE F , RIGAL‐SASTOURNE JC 
Published: August 2014

AbstractPurpose To assess clinical outcomes and optical performances of refractive cataract surgery with mutifocal toric intraocular lens (IOL).Methods This was a monocentric, retrospective review of cases, conducted at the Ophtalmology and Refractive Unit Percy, military Hospital, Clamart, FRANCE. This study included eyes presenting preoperative regular corneal astigmatism of 1D or greater, who underwent cataract surgery with implantation of a +3,75D multifocal toric hydrophilic IOL, by 2 differents surgeons. Ten eyes of seven patients were operated between 2012 and 2014. At the one month postoperative visit, we analysed visual acuity at various distances, spherical équivalent, refractive cylinder, spectacle independance, halos perception and patients satisfaction.Results The mean spherical équivalent was ‐0,4D at one month. Mean pre‐operative réfractive cylinder increased from ‐2,89D (ranged from ‐1 to ‐6,75D) to ‐0,67D (ranged from ‐0,5 to ‐1,0D). Mean monocular uncorrected visual acuities were 7,42/10 at 4 m (Monoyer) and ‐0,28 logMAR at preferred near (40cm). Mean corrected visual acuities were 9,56/10 at 4 m and ‐0,18 logMAR at near. 8 of 10 patients reported freedom from corrective wear, and 6 of 10 complained about halos perception. The mean score that patients rated their uncorrected visual acuity was 7,3 +‐ 0,6 on a scale of 0 to 10.Conclusion One month after implantation of a multifocal toric IOL, patients had significantly reduced spherical équivalent and refractive cylindre. They achieved good visual acuity across distances permiting spectacle independance for most of them.
Central nervous system abnormalities in retinoblastoma patients
Authors: DE FRANCESCO S , DE LUCA M , GALLUZZI P , HADJISTILIANOU T 
Published: August 2014

AbstractPurpose Presence of CNS abnormalities on MR images in a large group of patients with retinoblastoma (rtb) is evaluated. Mental retardation and congenital brain anomalies are reported in patients with rtb, mostly in combination with 13q deletion syndrome. Pinealoblastoma is the most important and “life threatening” condition associated with hereditary rtb, but recent studies suggest an association with pineal cysts. This association is important because some pinealoblastomas mimic pineal cysts.Methods CNS MR images of 420 consecutive patients with rtb from 2000 to 2014 were evaluated by neuroradiologists for tumors, structural anomalies, myelinization, and coincidental findings. Clinical records were reviewed for laterality, heredity, and the presence of the 13q del syndrome.Results Patients with bilateral and unilateral proved RB1‐germline mutation were 42 (48.2%) out of 87 hereditary cases. 9 patients had 13q deletion syndrome. Normal findings on brain MR images were seen in 307 out of 420 patients. 1 pinealoblastoma was detected in a patient with hereditary rtb, one arachnoid cyst in a sporadic unilateral RTB girl, 1 cerebral and corpus callosum atrophy and 3 pineal cysts were detected (2 non hereditary, 1 in 13q deletion syndrome). Corpus callosum agenesis was found in 3 patients (2 13q deletion syndrome, 1 hereditary RTB), corpus callosum hypoplasia in 3 patients (2 twins, 1 sporadic RTB), both in combination with 13q deletion syndrome.Conclusion Pinealoblastoma is associated with hereditary retinoblastoma, and structural brain abnormalities are associated not only with 13q deletion syndrome patients. Pineal cysts can be detected in patients with sporadic rtb and/or with 13q deletion syndrome.
Melanomalytic glaucoma secondary to iris melanoma
Authors: AJAMIL RODANES S , GARCIA‐ALVAREZ C , SAORNIL ALVAREZ M , LOPEZ‐LARA F , FRUTOS‐BARAJA JM , QUINONES M 
Published: August 2014

AbstractPurpose To report on an unusual form of adult onset iris melanoma as melanomalytic glaucoma.Methods A 35‐year‐old white male with a history of unilateral ocular hypertension and visual loss for six months.Results At first visit,Best Corrected Visual Acuity was 80/20 in the right eye (OD) and 20/20 in the left one (OS).Intraocular pressure was 40 mmHg in the OD and 10 mmHg in OS.Anterior segment examination of the OD showed a melanotic elevated lesion on the base of the iris from 8:00 to 9:00.Gonioscopy revealed extension into the anterior chamber angle and that a dense, brown, pigmented band at the filtration portion of the trabecular meshwork. Ophthalmoscopy demonstrated glaucomatous changes to the right optic disc. The patient was unresponsive to medical treatment for glaucoma. The clinical differential diagnosis was melanocytoma, nevus and melanoma. Excisional biopsy ( iridocycloresection ) was performed. Light microscopy showed proliferation of fusiform cells with pleomorphic nuclei in the iris stroma, immunopositive for HMB45 and Melan‐A. The final hystopathologic diagnosis was iris melanoma with dispersion of pigment in anterior‐chamber and secondary melanomalytic glaucoma. Plaque radiotherapy was performed as aConclusion In patients presenting unilateral glaucoma and increased pigmentation in the trabecular meswork it is crucial to perform imaging studies, such as ultrasound, in order to rule out the presence of an intraocular tumor. Early diagnosis improves the patients visual prognosis and the morbidity of treatments. Resection by iridectomy with adjuvant epiescleral brachytheraphy is effective in controlling the disease.
Clinical application of 3D monitor in ophthalmologic field: Measurement of metamorphopsia
Authors: KIM YT , KIM JW 
Published: August 2014

AbstractPurpose To develop a new tool of measuring metamorphopsia.Methods Fifty‐eight patients diagnosed with macular disease were examined. Images for three‐dimensional monitor were prepared. Macular optical coherence tomography and the Amsler grid test were also performed.Results The sensitivity of metamorphopsia was 66.7% with Amsler grid and 100% with three‐dimensional monitor. The specificity of metamorphopsia was 97.7% with Amsler grid and 90.7% with three‐dimensional monitor.Conclusion The detection rate of metamorphopsia in macular disease with three‐dimensional monitor was significantly higher than with Amsler grid. The three‐dimensional monitor may be used for the detection of metamorphopsia, moreover, they can be used even at home for the self‐assessment.
Reproducibility of retinal oximetry measurements in healthy and diseased retinas
Authors: TÜRKSEVER C , ORGÜL S , TODOROVA MG 
Published: August 2014

AbstractPurpose Retinal oximetry (RO) has been established as a non‐invasive method to analyse oxygen saturation in retinal vessels. The aim of our study was to determine the reproducibility of RO images in healthy and in diseased retinas.Methods A total of 46 right eyes (184 oximetry images) in 46 subjects (21♂, 25 ♀) were examined: 16 controls, 10 glaucoma patients and 20 patients with inherited retinal diseases. Four test‐retest RO images were obtained in each subject. Oxygen saturation was measured with the oxygen saturation measurement tool of the Retinal Vessel Analyser (RVA, IMEDOS Systems UG, Jena, Germany). The test‐retest standard deviation within the subject (±SDw) of the mean vessel oxygen saturation in retinal veins and in arteries, its coefficient of variation (CoV) and the interclass correlation coefficients (ICC) were analysed.Results The average test re‐test SDw in veins was ± 2.52% (CoV=4.30%) and in arteries ±1.62% (CoV=1.72%). Among controls, glaucoma eyes and eyes with inherited retinal diseases, the test re‐test SDw in veins were: ±2.17% (CoV=4.11%), ±2.81% (CoV=4.64%) and ±2.66% (CoV=4.28%) (p=0.361; one‐way ANOVA) respectively. The test‐retest SDw in arteries were: ±1.53% (CoV=1.65%), ±1.44% (CoV= 1.05%) and ± 1.83% (CoV=1.91%), respectively (p=0.633). The ICCs in veins were 0.77 in controls, 0.76 in glaucoma patients and 0.83 in patients with inherited retinal disease. The ICCs in arteries were respectively: 0.92, 0.77, and 0.93.Conclusion Reproducibility of retinal oxygen saturation in healthy, as well as in diseased retinas is excellent. Measurements in arteries seem more reliable when compared to veins.