bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piroxicam and laser phototherapy in the treatment of TMJ arthralgia: a double‐blind randomised controlled trial
Authors: de Carli M. L. , Guerra M. B. , Nunes T. B. , di Matteo R. C. , de Luca C. E. P. , Aranha A. C. C. , Bolzan M. C. , Witzel A. L. 
Published: December 2012

SummaryThis study aimed to evaluate the efficacy of piroxicam associated with low‐level laser therapy compared with single therapies in 32 patients presenting temporomandibular joint arthralgia in a random and double‐blind research design. The sample, divided into laser + piroxicam, laser + placebo piroxicam and placebo laser + piroxicam groups, was submitted to the treatment with infrared laser (830 nm, 100 mW, 28 s, 100 J cm−2) at 10 temporomandibular joint and muscle points on each side during four sessions concomitant to take one capsule a day of piroxicam 20 mg during 10 days. The treatment was evaluated throughout four sessions and 30 days follow‐up through visual analogue scale (VAS), maximum mouth opening and joint and muscle (temporal and masseter) pain on palpation. The results showed that all the study groups had a significant improvement in the VAS scores (P < 0·05), and there were no significant group differences. Piroxicam was effective in the reduction of joint and muscle pain on palpation (P < 0·05) and showed the lowest temporal pain (P = 0·02) at the 30‐day follow‐up. The combination of low‐level laser therapy and piroxicam was not more effective than single therapies in the treatment of temporomandibular joint arthralgia. The use of piroxicam was more effective in the following 30 days.
Situational and Dispositional Goal Adjustment in the Context of Metastatic Cancer
Authors: Thompson Elizabeth , Stanton Annette L. , Bower Julienne E. 
Published: December 2012

AbstractStriving toward goals is associated with higher levels of subjective well‐being; however, many potential roadblocks to goal achievement exist. The current study extends the understanding of goal regulation processes in its examination of the relationships between dispositional and situational goal adjustment to a profound stressor and their associations with psychological adjustment. Women (N = 103; M age = 57.2 years; 82% Caucasian) with metastatic breast cancer completed semistructured interviews and self‐report measures at study entry and 3 months later. Measures of dispositional and situational goal reengagement were significantly correlated, but dispositional and situational goal disengagement were unrelated. Greater dispositional and situational goal disengagement abilities were associated with fewer cancer‐related intrusive thoughts at Time 1. Dispositional and situational reengagement were positively associated with life satisfaction and sense of purpose and negatively associated with depressive symptoms at Time 1. However, greater initial situational goal disengagement predicted an increase in depressive symptoms over time. Both how an individual typically responds to goal blockage, as well as how an individual is currently responding to a specific blocked goal, appear related to psychological adjustment.
Disseminated tuberculosis and tuberculous meningitis in Australian‐born children; case reports and review of current epidemiology and management
Authors: Smith Benjamin B , Hazelton Briony J , Heywood Anita E , Snelling Thomas L , Peacock Kenneth M , Macartney Kristine K 
Published: December 2012

AbstractWe present two cases of tuberculous meningitis in Australian‐born children. We review the current literature surrounding management of paediatric tuberculosis and disseminated disease, emphasising the importance of prompt diagnosis and intervention. We discuss the epidemiology of tuberculosis in the Australian paediatric population and highlight the sentinel role of childhood infection in public health surveillance.
Implementing Inclusion and Collaborative Teaming in a Model Program of Postsecondary Education for Young Adults With Intellectual Disabilities
Authors: Folk Eric D. R. , Yamamoto Kathryn K. , Stodden Robert A. 
Published: December 2012

AbstractIn 2010, the U.S. Department of Education announced an initiative to improve transitioning to postsecondary education (PSE) for individuals with intellectual disabilities (ID) by funding the model comprehensive Transition and Postsecondary Programs for Students with Intellectual Disabilities (TPSID) program. The TPSID provides for grants to create or expand inclusive comprehensive transition and postsecondary programs for students with ID. The authors provide a descriptive report of one such TPSID‐funded demonstration in the state of Hawai‘i and share preliminary feedback from student participants, agency and institutional partners, and project staff. The authors' interviews with the participants and collaborators provided insights and perspectives of the challenges inherent in implementing such a demonstration model. They found that student participants with ID, who were culturally and linguistically diverse, relished the opportunity to participate in PSE and were motivated by the opportunity to learn, meet new people, and contribute to their families. Interagency partners valued the process and benefits of interagency teaming, with most reporting that participating in collaborative teaming resulted in a shift in their views on inclusion of students with ID in PSE. The authors concluded that the implementation of an inclusive PSE transition model can be a transformative process for students with ID, PSE institutions, and support agencies. Furthermore, that collaborative interagency teaming is a powerful method to inform and empower the implementation of change and stimulate and facilitate new opportunities and approaches to improve transition outcomes for students with ID.
Effects of Low-Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model
Authors: Qiu Xuefeng , Lin Guiting , Xin Zhongcheng , Ferretti Ludovic , Zhang Haiyang , Lue Tom F. , Lin Ching-Shwun 
Published: December 2012

ABSTRACT

Introduction
Low-energy shockwave therapy (LESWT) has been shown to improve erectile function in patients suffering from diabetes mellitus (DM)-associated erectile dysfunction (ED). However, the underlying mechanism remains unknown.

Aim
The aim of this study is to investigate whether LESWT can ameliorate DM-associated ED in a rat model and examine the associated changes in the erectile tissues.

Methods
Newborn male rats were intraperitoneally injected with 5-ethynyl-2-deoxyuridine (EdU; 50 mg/kg) for the purpose of tracking endogenous mesenchymal stem cells (MSCs). Eight weeks later, eight of these rats were randomly chosen to serve as normal control (N group). The remaining rats were injected intraperitoneally with 60 mg/kg of streptozotocin (STZ) to induce DM. Eight of these rats were randomly chosen to serve as DM control (DM group), whereas another eight rats were subject to shockwave (SW) treatment (DM+SW group). Each rat in the DM+SW group received 300 shocks at energy level of 0.1 mJ/mm2 and frequency of 120/minute. This procedure was repeated three times a week for 2 weeks. Another 2 weeks later, all 24 rats were evaluated for erectile function by intracavernous pressure (ICP) measurement. Afterward, their penile tissues were examined by histology.

Main Outcome Measures
Erectile function was measured by ICP. Neuronal nitric oxide synthase (nNOS)-positive nerves and the endothelium were examined by immunofluorescence staining. Smooth muscle and MSCs were examined by phalloidin and EdU staining, respectively.

Results
STZ treatment caused a significant decrease in erectile function and in the number of nNOS-positive nerves and in endothelial and smooth muscle contents. These DM-associated deficits were all partially but significantly reversed by LESWT. MSCs (EdU-positive cells) were significantly more numerous in DM+SW than in DM rats.

Conclusion
LESWT can partially ameliorate DM-associated ED by promoting regeneration of nNOS-positive nerves, endothelium, and smooth muscle in the penis. These beneficial effects appear to be mediated by recruitment of endogenous MSCs.
Hypoxia‐Inducible Factor‐1 Is a Determinant of Lobular Structure and Oxygen Consumption in the Liver
Authors: Tsukada Kosuke , Tajima Toshihide , Hori Shutaro , Matsuura Tomomi , Johnson Randall S. , Goda Nobuhito , Suematsu Makoto 
Published: December 2012

AbstractObjectiveHypoxia‐inducible factor is a hypoxia‐responsive transcriptional factor that controls the expression of proteins contributing to homeostatic responses to hypoxia. Spatial heterogeneity of tissue oxygenation has been postulated as a determinant of structure and function of hepatic lobules, although its molecular mechanisms remain unknown. This study aimed to examine the role of HIF‐1 expressed in hepatocytes in regulation of hepatic microcirculation.MethodsWe have generated mice harboring a floxed HIF‐1α allele, and employed the albumin‐Cre transgenic line to inactivate the gene site‐specifically in hepatocytes.ResultsIntravital observation of the hepatic microcirculation revealed extension of hepatic lobules in HIF‐1α‐deficient mice. Measurement of microvascular diameter, velocity, and local oxygen tension by laser‐assisted phosphorimetry showed that the oxygen consumption in the lobules of HIF‐1α‐deficient mice was greater than that in those of control mice. Isolated hepatocytes from HIF‐1α‐deficient mice also stimulated oxygen consumptions with increased contents of mtDNA. Overexpression of HIF‐1α decreased the expression of PGC‐1α mRNA, whereas the knockdown of the HIF‐1α gene increased it, suggesting that HIF‐1 regulates cellular respiration through mitochondrial biogenesis.ConclusionsOur results suggest that constitutive expression of HIF‐1α in hepatocytes acts as a determinant of hepatic lobular structure and oxygen consumption by changing mitochondrial contents.
Trees are major conduits for methane egress from tropical forested wetlands
Authors: Pangala Sunitha R. , Moore Sam , Hornibrook Edward R. C. , Gauci Vincent 
Published: December 2012

Summary

Wetlands are the largest source of methane to the atmosphere, with tropical wetlands comprising the most significant global wetland source component. The stems of some wetland‐adapted tree species are known to facilitate egress of methane from anoxic soil, but current ground‐based flux chamber methods for determining methane inventories in forested wetlands neglect this emission pathway, and consequently, the contribution of tree‐mediated emissions to total ecosystem methane flux remains unknown.

In this study, we quantify in situ methane emissions from tree stems, peatland surfaces (ponded hollows and hummocks) and root‐aerating pneumatophores in a tropical forested peatland in Southeast Asia.

We show that tree stems emit substantially more methane than peat surfaces, accounting for 62–87% of total ecosystem methane flux. Tree stem flux strength was controlled by the stem diameter, wood specific density and the amount of methane dissolved in pore water.

Our findings highlight the need to integrate this emission pathway in both field studies and models if wetland methane fluxes are to be characterized accurately in global methane budgets, and the discrepancies that exist between field‐based flux inventories and top‐down estimates of methane emissions from tropical areas are to be reconciled.
A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis
Authors: Hemsley Piers A. , Weimar Thilo , Lilley Kathryn S. , Dupree Paul , Grierson Claire S. 
Published: December 2012

Summary

S‐acylation (palmitoylation) is a poorly understood post‐translational modification of proteins involving the addition of acyl lipids to cysteine residues. S‐acylation promotes the association of proteins with membranes and influences protein stability, microdomain partitioning, membrane targeting and activation state. No consensus motif for S‐acylation exists and it therefore requires empirical identification.

Here, we describe a biotin switch isobaric tagging for relative and absolute quantification (iTRAQ)‐based method to identify S‐acylated proteins from Arabidopsis. We use these data to predict and confirm S‐acylation of proteins not in our dataset.

We identified c. 600 putative S‐acylated proteins affecting diverse cellular processes. These included proteins involved in pathogen perception and response, mitogen‐activated protein kinases (MAPKs), leucine‐rich repeat receptor‐like kinases (LRR‐RLKs) and RLK superfamily members, integral membrane transporters, ATPases, soluble N‐ethylmaleimide‐sensitive factor‐activating protein receptors (SNAREs) and heterotrimeric G‐proteins. The prediction of S‐acylation of related proteins was demonstrated by the identification and confirmation of S‐acylation sites within the SNARE and LRR‐RLK families. We showed that S‐acylation of the LRR‐RLK FLS2 is required for a full response to elicitation by the flagellin derived peptide flg22, but is not required for localization to the plasma membrane.

Arabidopsis contains many more S‐acylated proteins than previously thought. These data can be used to identify S‐acylation sites in related proteins. We also demonstrated that S‐acylation is required for full LRR‐RLK function.
Three‐dimensional analysis of facial shape and symmetry in twins using laser surface scanning
Authors: Djordjevic J. , Jadallah M. , Zhurov A. I. , Toma A. M. , Richmond S. 
Published: December 2012

Structured AbstractObjectivesThree‐dimensional analysis of facial shape and symmetry in twins.Setting and Sample PopulationFaces of 37 twin pairs [19 monozygotic (MZ) and 18 dizygotic (DZ)] were laser scanned at the age of 15 during a follow‐up of the Avon Longitudinal Study of Parents and Children (ALSPAC), South West of England.Material and MethodsFacial shape was analysed using two methods: 1) Procrustes analysis of landmark configurations (63 x, y and z coordinates of 21 facial landmarks) and 2) three‐dimensional comparisons of facial surfaces within each twin pair. Monozygotic and DZ twins were compared using ellipsoids representing 95% of the variation in landmark configurations and surface‐based average faces. Facial symmetry was analysed by superimposing the original and mirror facial images.ResultsBoth analyses showed greater similarity of facial shape in MZ twins, with lower third being the least similar. Procrustes analysis did not reveal any significant difference in facial landmark configurations of MZ and DZ twins. The average faces of MZ and DZ males were coincident in the forehead, supraorbital and infraorbital ridges, the bridge of the nose and lower lip. In MZ and DZ females, the eyes, supraorbital and infraorbital ridges, philtrum and lower part of the cheeks were coincident. Zygosity did not seem to influence the amount of facial symmetry. Lower facial third was the most asymmetrical.ConclusionThree‐dimensional analyses revealed differences in facial shapes of MZ and DZ twins. The relative contribution of genetic and environmental factors is different for the upper, middle and lower facial thirds.
Anxiety and Depression in Patients with an Implantable Cardioverter Defibrillator and Their Partners: A Longitudinal Study
Authors: VAN DEN BROEK KRISTA C. , HEIJMANS NAOMI , VAN ASSEN MARCEL A.L.M. 
Published: December 2012

BackgroundLittle is known about the relation between emotional distress of patients with an implantable cardioverter defibrillator (ICD) and distress of their partners. This longitudinal study aimed to determine the association between patient and partner distress, and to explain distress in patients and partners using demographic, clinical, and psychological characteristics of patients and partners.MethodsIn total, 343 patients (84% male, mean age = 63.2 ± 9.2 years) and partners (18% male, mean age = 60.3 ± 9.4 years) completed self‐report measures on anxiety and depressive symptoms at the time of implantation and at 2, 12, and 18 months follow‐up. Type D personality (DS14; nonexpression of negative emotions) was assessed at baseline. Clinical information was gathered from medical records. Multilevel modeling was applied.ResultsThe correlations between distress in patients and partners were positive (range r = 0.19–0.43; all P's < 0.001). Generally, partners experienced more anxiety and patients more depression. Patient and partner characteristics explained about half of the variance of distress of patients and partners. As expected, psychological characteristics had the strongest effect on distress. Patient anxiety was associated with patient depression and Type D, and to the corresponding distress variable of the partner (anxiety). Similar results were found for patient depression, partner anxiety, and partner depression.ConclusionDistress of ICD patients is associated with distress of their partners. Future studies need to investigate mechanisms of these patient‐partner dynamics, such as communication and behavioral issues. It may be timely to not only focus emotional support on patients, but also on their partners.
RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics
Authors: Ho Hsiang , Soto Hopkin Amelia , Kapadia Rubina , Vasudeva Priya , Schilling Jonathan , Ganesan Anand K. 
Published: December 2012

SummaryRho family GTPases regulate diverse processes in human melanoma ranging from tumor formation to metastasis and chemoresistance. In this study, a combination of in vitro and in vivo approaches was utilized to determine whether RHOJ, a CDC42 homologue that regulates melanoma chemoresistance, also controls melanoma migration. Depletion or overexpression of RHOJ altered cellular morphology, implicating a role for RHOJ in modulating actin cytoskeletal dynamics. RHOJ depletion inhibited melanoma cell migration and invasion in vitro and melanoma tumor growth and lymphatic spread in mice. Molecular studies revealed that RHOJ alters actin cytoskeletal dynamics by inducing the phosphorylation of LIMK, cofilin, and p41‐ARC (ARP2/3 complex subunit) in a PAK1‐dependent manner in vitro and in tumor xenografts. Taken together, these observations identify RHOJ as a melanoma linchpin determinant that regulates both actin cytoskeletal dynamics and chemoresistance by activating PAK1.
Linear Lupus Erythematosus Profundus as an Initial Manifestation of Systemic Lupus Erythematosus in a Child
Authors: Fernandes Sónia , Santos Sónia , Freitas Isabel , Salgado Manuel , Afonso Ana , Cardoso Jorge 
Published: December 2012

AbstractThe case of a 13‐year‐old Caucasian girl with a 1‐year history of a linear plaque on her thigh is reported. Histopathologic examination of the incisional biopsy tissue established the diagnosis of lupus erythematosus panniculitis. Six months later she developed the clinical and laboratory criteria for the diagnosis of systemic lupus erythematosus (SLE). She was treated with azathioprine and oral prednisolone, with a favorable clinical outcome. Our case illustrates a child with linear lupus erythematosus profundus as an initial manifestation of SLE. To our knowledge, only eight other cases of linear lupus erythematosus profundus have been reported in the literature, five in children. In contrast to our patient, none of those cases progressed to SLE during the reported follow‐up period. The authors report this case to illustrate an unusual superimposed segmental manifestation of an inflammatory polygenic disorder.
Goodbye Warts, Hello Vitiligo: Candida Antigen‐Induced Depigmentation
Authors: Wilmer Erin N. , Burkhart Craig N. , Morrell Dean S. 
Published: December 2012

AbstractDepigmentation after the use of topical immune modulators is a rare but reported event. Herein we present what is to our knowledge the first case of vitiligo at a site of Candida antigen injection.
UVB‐Induced Inflammatory Cytokine Release, DNA Damage and Apoptosis of Human Oral Compared with Skin Tissue Equivalents
Authors: Breger Joyce , Baeva Larissa , Agrawal Anant , Shindell Eli , Godar Dianne E. 
Published: December 2012

AbstractPeople can get oral cancers from UV (290–400 nm) exposures. Besides high outdoor UV exposures, high indoor UV exposures to oral tissues can occur when consumers use UV‐emitting tanning devices to either tan or whiten their teeth. We compared the carcinogenic risks of skin to oral tissue cells after UVB (290–320 nm) exposures using commercially available 3D‐engineered models for human skin (EpiDerm™), gingival (EpiGing™) and oral (EpiOral™) tissues. To compare the relative carcinogenic risks, we investigated the release of cytokines, initial DNA damage in the form of cyclobutane pyrimidine dimers (CPDs), repair of CPDs and apoptotic cell numbers. We measured cytokine release using cytometric beads with flow cytometry and previously developed a fluorescent immunohistochemical assay to quantify simultaneously CPD repair rates and apoptotic cell numbers. We found that interleukin‐8 (IL‐8) release and the initial CPDs are significantly higher, whereas the CPD repair rates and apoptotic cell numbers are significantly lower for oral compared with skin tissue cells. Thus, the increased release of the inflammatory cytokine IL‐8 along with inefficient CPD repair and decreased death rates for oral compared with skin tissue cells suggests that mutations are accumulating in the surviving population of oral cells increasing people's risks for getting oral cancers.
Attachment disorganization moderates the effect of maternal postnatal depressive symptoms on infant autonomic functioning
Authors: Tharner Anne , Dierckx Bram , Luijk Maartje P.C.M. , van Ijzendoorn Marinus H. , Bakermans‐Kranenburg Marian J. , van Ginkel Joost R. , Moll Henriette A. , Jaddoe Vincent W.V. , Hofman Albert , Hudziak James J. , Verhulst Frank C , Tiemeier Henning 
Published: December 2012

AbstractWe examined associations of disorganized attachment and maternal depressive symptoms with infant autonomic functioning in 450 infant‐mother dyads enrolled in the Generation R study. Maternal depressive symptoms were measured 2 months postpartum with the Brief Symptom Inventory. At 14 months, we assessed infant attachment with a slightly shortened Strange Situation and measured infant resting heart rate. Respiratory sinus arrhythmia (RSA) was calculated using spectral analysis. Higher levels of maternal postnatal depressive symptoms predicted lower resting RSA in disorganized infants (B = −0.31, SE = 0.15, p = .04, R2 = .05) but not in nondisorganized infants (B = 0.05, SE = 0.06, p = .36). This effect was buffered in disorganized infants with a secondary secure attachment classification. Disorganized infants were more vulnerable to the effect of maternal postnatal depressive symptoms on the physiological stress systems.
Specific fear modulates attentional selectivity during visual search: Electrophysiological insights from the N2pc
Authors: Weymar Mathias , Gerdes Antje B. M. , Löw Andreas , Alpers Georg W. , Hamm Alfons O. 
Published: December 2012

AbstractIn the present study, we used high‐density EEG during a visual search task to investigate the dynamics of spatial attention to fear‐relevant targets and background stimuli in small animal phobia during a visual search task. Twenty‐five spider fearful (22 females) and 25 healthy nonfearful participants (19 females) were measured, while searching for discrepant objects in visual arrays. Compared to nonfearful participants, spider fearful individuals showed a more enhanced posterior N2pc to spider (vs. butterfly) targets in an array of flowers. Furthermore, spider fearful participants showed enhanced hypervigilance for all presented stimuli compared to controls as reflected by enhanced N1 amplitudes (160–200 ms). Our findings provide neural evidence for early, enhanced selective spatial attention for fear‐relevant stimuli.