bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contested geopolitics of distribution in the city‐region‐building: Promoting enclave industrial parks in the Pearl River Delta, China
Authors: Zhang Xianchun , Zhou Zihang , Song Yang 
Published: July 2024

AbstractThe discourse on the ascendancy of city‐regions as a geopolitical framework predominately derives from neoliberal experiences, articulating the interplay between the politics of city‐regional distribution and the evolving role of the state in distribution governance, alongside the challenges related to post‐suburban development. Given the diverse political and economic frameworks across the state, exploring the geopolitics of city‐regional distribution beyond overwhelmed neoliberal assumptions is imperative. This study aims to explicate alternative geopolitics of distribution within China's recent city‐region‐building. Through studying the negotiation and development of two Enclave Industrial Parks (EIPs) in the Pearl River Delta, Southern China, we recontextualise the centrally orchestrated city‐regional distribution within the authoritarian framework of the developmental party‐state. We propose a conceptual framework delineating the transitional rationality of the multi‐scalar state, illustrating the political and territorial negotiation of distribution within a hierarchical resource arrangement. We argue that authoritarian distribution schemes, while manipulating the market regime, do not inherently impede the local distribution. Nonetheless, political and territorial mandates on city‐region‐building, which arbitrarily redefine the opportunities of local communities, perpetuate an authoritarian and contested nature of distribution, ultimately contributing to widening regional development disparities in contemporary China.
Method comparison between hematopoietic progenitor cell and CD34+ cell counts in hematopoietic stem cell collection
Authors: Lavalleye Thibault , Saussoy Pascale , Lambert Catherine 
Published: July 2024

AbstractBackgroundThe reference method for hematopoietic stem cell enumeration is flow cytometric CD34+ cell analysis. We evaluated using the hematopoietic progenitor cell (HPC) count on the Sysmex hematology analyzer to safely replace some flow cytometric measurements performed in peripheral blood samples to guide apheresis timing.Study Design and MethodsWe compared HPC and CD34+ cell counts in 133 preharvest peripheral blood samples and 124 apheresis products.ResultsPre‐apheresis HPC counts ≥24 × 106/L in healthy donors and ≥36 × 106/L in lymphoma patients predicted adequate mobilization with 100% specificity and positive predictive value, saving 79% and 63% of flow cytometry analyses, respectively. Due to a positive bias (mean bias 50.26; 95% CI 36.24–64.29), a higher threshold was needed in multiple myeloma patients (HPC 132 × 106/L), saving only 24% of flow cytometry analyses.ConclusionWhen the HPC count is above the corresponding threshold, apheresis could be safely initiated without waiting for the flow cytometry result, thereby reducing time‐to‐decision. Lower HPC values, however, require confirmation by flow cytometry.
Optimized high‐dose granulocyte transfusions for the treatment of infections in neutropenic patients: A single‐center retrospective analysis
Authors: Hadjiyannis Yannis , Bubar Robert , Triulzi Darrell J. , Kiss Joseph , Marino Christopher C. , Kaplan Alesia 
Published: July 2024

AbstractBackgroundGranulocyte transfusions for patients with prolonged neutropenia and severe infections has been a controversial practice. Previous studies suggest a benefit of high‐dose granulocyte transfusions (≥0.6 × 109/kg), although, until recently, the consistent production of high‐dose units has been challenging. Here, we present our experience and results utilizing high‐dose granulocyte transfusions at a large, tertiary academic medical center for the treatment of infections in adult, neutropenic patients.Study Design/MethodsA retrospective chart review (2018–2021) was conducted for all patients who received high‐dose granulocyte transfusions from donors stimulated with granulocyte colony‐stimulating factor (G‐CSF) and dexamethasone. Gathered parameters included patient demographics, clinical history, infection status, dose, clinical outcomes, pre‐ and post‐absolute neutrophil count (ANC), and transfusion times including time between granulocyte collection, administration, and posttransfusion ANC count. Gathered parameters were summarized using descriptive statistics, outcomes were assessed utilizing Kaplan–Meier curves/log‐rank/regression testing.ResultsTotally 28 adult, neutropenic patients refractory to antimicrobial agents and/or G‐CSF received a total of 173 granulocyte concentrates. Median ANC increased from 0.7 × 109/L pre‐transfusion to 1.6 × 109/L posttransfusion. The mean granulocyte yield was 77.4 × 109 resulting in an average dose per kilogram of 0.90 × 109 ± 0.30 × 109 granulocytes. Composite day 42 survival and microbial response was 42.9% (n = 12/28) without significant adverse reactions.DiscussionHere, we demonstrate the successful and safe implementation of high‐dose granulocyte transfusions for neutropenic patients. Given the rapid and consistent production, distribution, and improved granulocyte quality, further investigations to determine the clinical efficacy of G‐CSF primed granulocyte transfusions is now possible.
Growth differentiation factor 15 is not modified after weight loss induced by liraglutide in South Asians and Europids with type 2 diabetes mellitus
Authors: Hoekx Carlijn A. , Straat Maaike E. , Bizino Maurice B. , van Eyk Huub J. , Lamb Hildebrandus J. , Smit Johannes W. A. , Jazet Ingrid M. , de Jager Saskia C. A. , Boon Mariëtte R. , Martinez‐Tellez Borja 
Published: July 2024

AbstractGlucagon‐like peptide‐1 receptor (GLP‐1R) agonists induce weight loss in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is unclear. Recently, the mechanism by which metformin induces weight loss could be explained by an increase in growth differentiation factor 15 (GDF15), which suppresses appetite. Therefore, we aimed to investigate whether the GLP‐1R agonist liraglutide modifies plasma GDF15 levels in patients with T2DM. GDF15 levels were measured in plasma samples obtained from Dutch Europids and Dutch South Asians with T2DM before and after 26 weeks of treatment with daily liraglutide (n = 44) or placebo (n = 50) added to standard care. At baseline, circulating GDF15 levels did not differ between South Asians and Europids with T2DM. Treatment with liraglutide, compared to placebo, decreased body weight, but did not modify plasma GDF15 levels in all patients, or when data were split by ethnicity. Also, the change in plasma GDF15 levels after treatment with liraglutide did not correlate with changes in body weight or HbA1c levels. In addition, the dose of metformin used did not correlate with baseline plasma GDF15 levels. Compared to placebo, liraglutide treatment for 26 weeks does not modify plasma GDF15 levels in Dutch Europid or South Asian patients with T2DM. Thus, the weight loss induced by liraglutide is likely explained by other mechanisms beyond the GDF15 pathway.Highlights
What is the central question of this study?Growth differentiation factor 15 (GDF15) suppresses appetite and is increased by metformin: does the GLP‐1R agonist liraglutide modify plasma GDF15 levels in patients with type 2 diabetes mellitus (T2DM)?
What is the main finding and its importance?Plasma GDF15 levels did not differ between South Asians and Europids with T2DM and were not modified by 26 weeks of liraglutide in either ethnicity. Moreover, there was no correlation between the changes in plasma GDF15 levels and dosage of metformin administered, changes in body weight or HbA1c levels. The appetite‐suppressing effect of liraglutide is likely exerted via pathways other than GDF15.
Spacer Fluids for Use With Rock-Based Geopolymer
Authors: Khalili P. , Khalifeh M. , Saasen A. , Djuve J. , Delabroy L. 
Published: July 2024

Abstract
Developing a spacer fluid compatible with geopolymers and capable of facilitating effective mud displacement becomes imperative when considering the utilization of geopolymers as a complete substitute for cement in oil and gas well cementing. Drilling fluid contamination can impair the properties of geopolymer essential for zonal isolation. This study aims to design a spacer fluid tailored for geopolymer by first adjusting its rheological properties using rheology additives such as xanthan gum (XG), polyanionic cellulose (PAC), and bentonite to maintain viscosity hierarchy and aid in better mud removal. Followingly, the surfactant content in the spacer is adjusted to ensure its ability to clean the static mud layer on the surfaces and water-wet them, ultimately improving the geopolymer bonding. Lastly, the degree of compatibility of the optimized spacer and geopolymer was determined by examining the rheological properties, and compressive and tensile strength of the geopolymer when intermixing happens. These two fluids showed rheological compatibility based on the calculated R-index, an index frequently used in the petroleum industry for determining fluid compatibility. However, the gel strength was high for 25/75 geopolymer/spacer mixture. Solid to water and granite to ground granulated blast-furnace slag (GGBFS) ratio of the hardening spacer affected the degree of curing compatibility, aligning with the sensitivity of geopolymer to variations in GGBFS and water content. Heat evolution of the geopolymer showed that excessive water can hinder the dissolution of the aluminosilicate phase and later the geopolymerization reaction.
A Posteriori Error Analysis of Defect Correction Method for Singular Perturbation Problems With Discontinuous Coefficient and Point Source
Authors: Kaushik Aditya , Jain Shivani 
Published: July 2024

Abstract
The paper presents a defect correction method to solve singularly perturbed problems with discontinuous coefficient and point source. The method combines an inexpensive, lower-order stable, upwind difference scheme and a higher-order, less stable central difference scheme over a layer-adapted mesh. The mesh is designed so that most mesh points remain in the regions with rapid transitions. A posteriori error analysis is presented. The proposed numerical method is analyzed for consistency, stability, and convergence. The error estimates of the proposed numerical method satisfy parameter-uniform second-order convergence on the layer-adapted grid. The convergence obtained is optimal because it is free from any logarithmic term. The numerical analysis confirms the theoretical error analysis.
Spatial Coherence of Exciton–Polariton Bose–Einstein Condensates
Authors: Kuznetsova N. V. , Makarov D. V. , Asriyan N. A. , Elistratov A. A. , Lozovik Yu. E. 
Published: July 2024

Abstract
The dynamics of an exciton–polariton Bose–Einstein condensate in an optical microcavity was considered. A novel version of the stochastic Gross–Pitaevskii equation was proposed to describe the condensate evolution under the non-Markovian interaction with the environment. The proposed version was used to analyze the condensate dynamics at various temperatures. The phase transition from the homogeneous to the fragmented state of the condensate near a temperature of 15 K was detected. This phase transition is accompanied by a sharp drop in the condensate density and a decrease in the correlation length. It was found that, at a temperature of 10 K, the correlation length oscillates with time. The results obtained indicated the necessity to take into account the non-Markovianity of the condensate interaction with the excitonic reservoir.
Predictors of successful neonatal intubation in inexperienced operators: a secondary, non-randomised analysis of the SHINE trial
Authors: Hodgson Kate Alison , Selvakumaran Sharoan , Francis Kate Louise , Owen Louise S , Newman Sophie E , Kamlin Camille Omar Farouk , Donath Susan , Roberts Calum T , Davis Peter G , Manley Brett James 
Published: July 2024

ObjectiveNeonatal endotracheal intubation is a lifesaving but technically difficult procedure, particularly for inexperienced operators. This secondary analysis in a subgroup of inexperienced operators of the Stabilization with nasal High flow during Intubation of NEonates randomised trial aimed to identify the factors associated with successful intubation on the first attempt without physiological stability of the infant.MethodsIn this secondary analysis, demographic factors were compared between infants intubated by inexperienced operators and those intubated by experienced operators. Following this, for inexperienced operators only, predictors of successful intubation without physiological instability were analysed.ResultsA total of 251 intubations in 202 infants were included in the primary intention-to-treat analysis of the main trial. Inexperienced operators were more likely to perform intubations in larger and more mature infants in the neonatal intensive care unit where premedications were used. When intubations were performed by inexperienced operators, the use of nasal high flow therapy (nHF) and a higher starting fraction of inspired oxygen were associated with a higher rate of safe, successful intubation on the first attempt. There was a weaker association between premedication use and first attempt success.ConclusionsIn inexperienced operators, this secondary, non-randomised analysis suggests that the use of nHF and premedications, and matching the operator to the infant and setting, may be important to optimise neonatal intubation success.Trial registration numberACTRN12618001498280.
Resolution of multiorgan sarcoid-like reaction after treatment of renal cell carcinoma
Authors: Patil Monish , Breish Mohamed Omran , Madaan Sanjeev , Bhattacharjee Bikram 
Published: July 2024

Sarcoid -like reactions (SLRs) can occur in several malignancies adjacent to primary tumour location or the draining lymph nodes. The presence of peritumoural and intratumoural SLR in patients suffering from renal cell carcinoma (RCC) has been reported in few instances. However, the association of RCC with SLR in spleen, liver and other organs in the absence of systemic sarcoidosis is very rare.We present an unusual case of a gentleman in his 30s, who presented with a lesion in the left kidney along with non-specific lesions (likely granulomatous) in liver, spleen and lungs. Partial Nnephrectomy specimen confirmed conventional/clear cell RCC. The histopathology revealed an extensive epithelioid granulomatous reaction affecting both peritumoural and intratumoural areas. Follow-up images demonstrated an almost complete resolution of lesions in the spleen, liver and lungs. Our case supports the hypothesis that non-caseating granulomas of SLR could be a manifestation of an immunologically mediated antitumour response.
Quantitative assessment of colour fundus photography in hyperopia children based on artificial intelligence
Authors: Luo Ruiyu , Wang Zhirong , Li Zhidong , Xie Rui , Zhang Yuan , Ye Guitong , Chen Jianqi , Xiao Yue , Zhan Jinan , Zhu Yingting , Zhuo Yehong 
Published: July 2024

ObjectivesThis study aimed to quantitatively evaluate optic nerve head and retinal vascular parameters in children with hyperopia in relation to age and spherical equivalent refraction (SER) using artificial intelligence (AI)-based analysis of colour fundus photographs (CFP).Methods and analysisThis cross-sectional study included 324 children with hyperopia aged 3–12 years. Participants were divided into low hyperopia (SER+0.5 D to+2.0 D) and moderate-to-high hyperopia (SER≥+2.0 D) groups. Fundus parameters, such as optic disc area and mean vessel diameter, were automatically and quantitatively detected using AI. Significant variables (p<0.05) in the univariate analysis were included in a stepwise multiple linear regression.ResultsOverall, 324 children were included, 172 with low and 152 with moderate-to-high hyperopia. The median optic disc area and vessel diameter were 1.42 mm2and 65.09 µm, respectively. Children with high hyperopia had larger superior neuroretinal rim (NRR) width and larger vessel diameter than those with low and moderate hyperopia. In the univariate analysis, axial length was significantly associated with smaller superior NRR width (β=−3.030, p<0.001), smaller temporal NRR width (β=−1.469, p=0.020) and smaller vessel diameter (β=−0.076, p<0.001). A mild inverse correlation was observed between the optic disc area and vertical disc diameter with age.ConclusionAI-based CFP analysis showed that children with high hyperopia had larger mean vessel diameter but smaller vertical cup-to-disc ratio than those with low hyperopia. This suggests that AI can provide quantitative data on fundus parameters in children with hyperopia.
Neurological outcomes for patients meeting radiographic criteria for DEFUSE 3 and SELECT2
Authors: Karamchandani Rahul R , Satyanarayana Sagar , Yang Hongmei , Strong Dale , Rhoten Jeremy , Clemente Jonathan , Defilipp Gary , Patel Nikhil M , Bernard Joe , Stetler William , Parish Jonathan M , Albers Gregory W , Heit Jeremy J , Guzik Amy K , Wolfe Stacey Q , Hines Andrew , Patel Harsh N , Helms Anna Maria , Macko Lauren , Williams Laura , Retelski Julia , Asimos Andrew W 
Published: July 2024

BackgroundThe DEFUSE 3 and SELECT2 thrombectomy trials included some patients with similar radiographic profiles, although the rates of good functional outcomes differed widely between the studies.ObjectiveTo report neurological outcomes for patients who meet CT and CT perfusion (CTP) inclusion criteria common to both DEFUSE 3 and SELECT2.MethodsRetrospective study of thrombectomy patients, presenting between November 2016 and December 2023 to a large health system, with Alberta Stroke Program Early CT score ≥6, core infarction 50–69 mL, mismatch ratio ≥1.8, and mismatch volume ≥15 mL. The primary outcome was 90-day modified Rankin Scale score 0–2. A logistic regression analysis was performed to identify independent predictors of the primary outcome.Results85 patients, with mean age 64.6 (16.6) years and median National Institutes of Health Stroke Scale score 18 (15–23), were included. Thirty-eight of 85 patients (44.7%) were functionally independent at 90 days. Predictors of functional independence included age (OR=0.943, 95% CI 0.908 to 0.980; P=0.003), initial glucose (OR=0.989, 95% CI 0.978 to 1.000; P=0.044), and time last known well to skin puncture (OR=0.997, 95% CI 0.994 to 1.000; P=0.028). The area under the curve for the multivariable model predicting the primary outcome was 0.82 (95% CI 0.73 to 0.92).ConclusionNearly half of patients meeting radiographic criteria common to DEFUSE 3 and SELECT2 are functionally independent at 90 days, similar to rates reported for the treated DEFUSE 3 cohort. This might be due to their moderate core volumes and large ischemic penumbra.
Effects of interventions implemented by occupational health professionals to prevent work-related stress complaints: a systematic review
Authors: Orhan Pees Suzanne , van Oostrom Sandra , Lettinga Hanneke , Schaafsma Frederieke , Proper Karin 
Published: July 2024

Work-related stress complaints are a growing societal problem. Occupational health professionals often play a key role in its prevention. However, studies providing an overview of preventive interventions and their effectiveness are lacking. Therefore, the aim of this systematic review was to summarise the evidence on the effectiveness of interventions delivered by occupational health professionals to prevent work-related stress complaints.A systematic search in PubMed, Embase, PsycInfo and Medline was performed in May 2023 based on PICO (population, intervention, control and outcomes) elements. Inclusion criteria were: peer-reviewed papers with a randomised controlled trial design, quasi-experimental design and pre-post evaluations with a control group; working populations not on sick leave; interventions delivered by occupational health professionals; and stress outcomes. Data were extracted using a predefined extraction form, risk of bias was assessed using the Cochrane risk of bias tool for randomised trials (RoB-2) and Risk of Bias in non-randomised Studies-of Interventions tool, and a narrative analysis was performed to summarise data.Nine studies were included in this review and encompassed a diverse range of populations, interventions and professionals involved, outcome measures, and effects observed. Five studies found either mixed effects on stress outcomes, short-term positive effects, or positive effects in a subgroup of participants demonstrating high adherence to the intervention.As the results show mixed findings, a high risk of bias, and a limited number of studies was available, more research is needed to the effectiveness of the interventions and the factors underlying this.
Assessment of catheter position using chest CT in adults undergoing erector spinae plane analgesia for rib fractures: a retrospective cohort study
Authors: Wu Maylyn , Barrak Charbel , Forrest Patrick , Rizzo Derek , Guerra-Londono Carlos Eduardo 
Published: July 2024

BackgroundContinuous erector spinae plane (ESP) analgesia is a common adjuvant for patients with traumatic rib fracture pain and success relies on the ESP catheter remaining within the correct fascial plane for the duration of its placement. However, knowledge on postplacement position of indwelling ESP catheters is largely absent. We hypothesized that migration of over-the-needle ESP catheters was common and detectable with coincidental postprocedure CT.MethodsIn this single-center retrospective cohort study, adults admitted to the surgical intensive care unit for traumatic rib fractures between January 2020 and July 2022 were screened. Those receiving continuous ESP analgesia via indwelling catheter and undergoing subsequent chest CT were included. The primary outcome was the proportion of catheters that migrated outside the ESP. The secondary outcome was the distance between the catheter tip and the nearest transverse process (TP) or fascial plane.Results160 medical records were screened for eligibility and 15 patients (18 catheters) met the inclusion criteria. 16 of 18 catheters reviewed were found outside the ESP. Furthermore, catheter position was reported as intramuscular in 14 catheters and subcutaneous in 4 catheters. The median distance between catheter tip and the nearest TP (or the ESP) was 23.20 mm sagittally and 25.05 mm axially.ConclusionsMost ESP catheters were found superficial to the fascial plane in the days following their placement. The median distance between the catheter and the ESP is between 23 and 25 mm. Prospective studies should address catheter migration concerns and propose solutions to this common issue.