bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn’s versus ulcerative colitis patients
Authors: Bsat Marwa , Chapuy Laurence , Baba Nobuyasu , Rubio Manuel , Panzini Benoit , Wassef Ramses , Richard Carole , Soucy Genevieve , Mehta Heena , Sarfati Marika 
Published: July 2015

Abstract
Human Slan DCs have been studied in patients with psoriasis, rheumatoid arthritis, cancer, and autoimmune diseases. In this study, we investigated the frequency, phenotype, and function of Slan DCs in blood, colon, as well as mLNs of patients with IBD. We first show that the frequency of circulating CD14dullSlan DCs was reduced in CD patients refractory to immunosuppressive drugs or TNF-α blockers relative to untreated CD, UC, and healthy subjects. In blood of CD patients, Slan DCs expressed CD172a, as detected by CD47 fusion protein binding, when compared with its lack of expression in control subjects. Next, we demonstrate that CD172a+Slan DCs that produced IL-1β and TNF-α accumulated in mLNs and colons of CD patients. The CD172a+Slan DCs up-regulated their expression of CD14 in CD tissues and the proinflammatory cytokines were produced in CD14brightCD172a+Slan DCs. By contrast, no difference was noted in the frequency of Slan DCs between inflamed, noninflamed colonic mucosa of UC patients and control, non-IBD donors. Finally, the percentage of cytokine-producing Slan DCs also augmented in response to TLR2 and NOD2 in in vitro stimulation in PBMCs of CD, but not UC, patients. In conclusion, we propose that proinflammatory CD14brightCD172a+Slan DCs are a distinguishing feature between CD and UC, as these cells accumulate uniquely in mLNs and colonic mucosa of CD patients. Thus, Slan DCs may contribute to CD immunopathogenesis.
Enhanced Terahertz Emission from CuxO/Metal Thin Film Deposited on Columnar-Structured Porous Silicon
Authors: Lu Xu , Ishida Yohei , Mishina Tomobumi , Nguyen Mai Thanh , Yonezawa Tetsu 
Published: July 2015

Abstract
We propose a novel method to enhance the THz emission from CuxO/metal nano thin film by using columnar-structured microsized porous silicon (MS-PSi) as the substrate. THz emission was improved several times higher than that from the planar substrate due to the decreased optical reflectance and enlarged surface area.
Performance of a Tuberculosis Serologic Assay in Various Patient Populations
Authors: She Rosemary C. , Litwin Christine M. 
Published: July 2015

Abstract

Objectives:
Detection of the humoral response to diagnose active tuberculosis has had varied success. We sought to further characterize the performance of a commercial serologic assay (Active TBDetect IgG ELISA; InBios International, Seattle, WA), which had demonstrated promising results in prior studies.

Methods:
Blood specimens from patients with mycobacterial infections, autoimmune disorders, and documented nonmycobacterial infections were prospectively collected for testing by the Active TBDetect IgG ELISA. Pertinent medical records were reviewed.

Results:
The sensitivity of the InBios IgG ELISA for active tuberculosis cases was 54.1% (20/37). Reactivity occurred in 24.1% (14/58) of nontuberculous mycobacterium cases, 10.4% (7/67) of nonmycobacterial infections, 10.5% (11/105) of autoimmune disorder cases, 8.7% (8/92) of noninfected patients, 14.3% (1/7) of patients with latent tuberculosis, and 10.7% (3/28) of control pediatric cases. Overall specificity was 87.5% (288/329). Receiver operator curve analysis demonstrated an area under the curve of 0.74. Reactivity with nontuberculous mycobacterium infection occurred with Mycobacterium avium-intracellulare complex, Mycobacterium chelonae/abscessus complex, Mycobacterium simiae, and Mycobacterium gordonae and was positively associated with having a positive acid-fast bacilli smear.

Conclusions:
This study confirmed the limitations of serodiagnosis for active tuberculosis, including poor sensitivity and increased reactivity with nontuberculous mycobacterium-positive patients.
The ARMC5 gene shows extensive genetic variance in primary macronodular adrenocortical hyperplasia
Authors: Correa Ricardo , Zilbermint Mihail , Berthon Annabel , Espiard Stephanie , Batsis Maria , Papadakis Georgios Z , Xekouki Paraskevi , Lodish Maya B , Bertherat Jerome , Faucz Fabio R , Stratakis Constantine A 
Published: July 2015

ObjectivePrimary macronodular adrenal hyperplasia (PMAH) is a rare type of Cushing's syndrome (CS) that results in increased cortisol production and bilateral enlargement of the adrenal glands. Recent work showed that the disease may be caused by germline and somatic mutations in the ARMC5 gene, a likely tumor suppressor gene (TSG). We investigated 20 different adrenal nodules from one patient with PMAH for ARMC5 somatic sequence changes.DesignAll of the nodules were obtained from a single patient who underwent bilateral adrenalectomy. DNA was extracted by standard protocol and the ARMC5 sequence was determined by the Sanger method.ResultsSixteen of 20 adrenocortical nodules harbored, in addition to what appeared to be the germline mutation, a second somatic variant. The p.Trp476* sequence change was present in all 20 nodules, as well as in normal tissue from the adrenal capsule, identifying it as the germline defect; each of the 16 other variants were found in different nodules: six were frame shift, four were missense, three were nonsense, and one was a splice site variation. Allelic losses were confirmed in two of the nodules.ConclusionThis is the most genetic variance of the ARMC5 gene ever described in a single patient with PMAH: each of 16 adrenocortical nodules had a second new, ‘private,’ and – in most cases – completely inactivating ARMC5 defect, in addition to the germline mutation. The data support the notion that ARMC5 is a TSG that needs a second, somatic hit, to mediate tumorigenesis leading to polyclonal nodularity; however, the driver of this extensive genetic variance of the second ARMC5 allele in adrenocortical tissue in the context of a germline defect and PMAH remains a mystery.
On the structure of some minimax-antifinitary modules
Authors: Chupordia V.A. 
Published: July 2015

Let $R$ be a ring and $G$ a group. An $R$-module $A$ is said to be {\it minimax} if $A$ includes a noetherian submodule $B$ such that $A/B$ is artinian. The author study a $\mathbb{Z}_{p^\infty}G$-module $A$ such that $A/C_A(H)$ is minimax as a $\mathbb{Z}_{p^\infty}$-module for every proper not finitely generated subgroup $H$.
New approach to derivation of quantum kinetic equations with initial correlations
Authors: Gerasimenko V.I. 
Published: July 2015

We propose a new approach to the derivation of kinetic equations from dynamics of large particle quantum systems, involving correlations of particle states at initial time. The developed approach is based on the description of the evolution within the framework of marginal observables in scaling limits. As a result the quantum Vlasov-type kinetic equation with initial correlations is constructed and the statement relating to the property of a propagation of initial correlations is proved in a mean field limit.
Index of pseudo-projectively-symmetric semi-Riemannian manifolds
Authors: Gupta P. 
Published: July 2015

The index of $\widetilde{\nabla}$-pseudo-projectively symmetric and in particular for $\widetilde{\nabla}$-projectively symmetric semi-Riemannian manifolds, where $\widetilde{\nabla}$ is Ricci symmetric metric connection, are discussed.
Elaboração e qualidade de geleia e compota de abacaxi “pérola"
Authors: Pereira Emmanuel Moreira , Leite Filho Manoel Tolentino , Santos Yvana Maria Gomes dos , Pereira Bárbara Bruna Maniçoba , Maracajá Paticio Borges 
Published: July 2015

<p>O abacaxi é uma fruta largamente consumida no país sendo na forma processada ou in natura. Objetivou-se neste trabalho elaborar uma formulação de geleia e compota de abacaxi tipo “pérola” e sua composição físico-química. Objetivou-se elaborar geleia e compota de abacaxi “perola” e a sua composição físico-química. O experimento foi conduzido no Laboratório de Pesquisa e Desenvolvimento de Produtos Frutohortícolas – PDFRUTHO, Campus Bananeiras – Bananeiras/PB, pertencente à Universidade Federal da Paraíba. As etapas utilizadas na elaboração da compota foram: seleção, lavagem e sanitização, extração da polpa, formulação, concentração, envase, resfriamento e rotulagem. Para os parâmetros químicos avaliados foram pH, vitamina C, sólidos solúveis (SS), acidez titulável (AT) e a condutividade elétrica. A geleia obtida apresentou valor de pH3,94, o teor de acidez titulável foi de 0,24 ( em ácido cítrico) de sólidos solúveis totais (SS) de 37,94°Brix, de vitamina C de 1,84 mg/100 g e condutividade elétrica de 79,86uS. Os SS encontrados nas formulações encontram-se dentro dos padrões recomendados para geleias. A compota obtida apresentou valor de pH de 3,36, a AT foi de 0,4, SS de 32°Brix, de vitamina C de 3,36 mg/100 g e CE de 718 uS. Os SS encontrados nas formulações estão dentro dos padrões recomendados para doces em calda.</p>
Effect of Adalimumab on Work Ability Assessed in Rheumatoid Arthritis Disease Patients in Saudi Arabia (AWARDS)
Authors: Hussain Waleed , Janoudi Nahid , Noorwali Abdulsalam , Omran Narges , Baamer Matouqa , Assiry El Hussain , Alrayes Hanan , Alosaimi Hanan , Ibrahim Ashraf , Gohary Shereen , Minguet Joan , Almoallim Hani 
Published: July 2015

Objectives :
Rheumatoid arthritis (RA) is a chronic disabling disease that can jeopardize the ability of affected individuals to participate in paid work. Our objective was to evaluate the effectiveness of a 6-month course of tumor necrosis factor (TNF) antagonist (adalimumab) on work ability, overall health, and fatigue in RA patients.

Methods :
Between October 2012 and February 2014, this prospective, observational study enrolled 63 consecutive patients with established adult RA at outpatient clinics in Makkah, Jeddah, Riyadh and Abha (Saudi Arabia). Patients received subcutaneous injections of adalimumab (40 mg every 2 weeks). Outcomes were measured at baseline and 6 months using the following tools: Work Productivity and Activity Impairment (WPAI), Health Assessment Questionnaire Disability Index (HAQ-DI), Fatigue Severity Scale (FSS), Visual Analog Scale for Fatigue (VAS-F), and work disability self-assessment.

Results :
All outcomes showed improvements after 6 months of adalimumab therapy. Significant improvements from baseline were observed in absenteeism (64% ± 11.62 to 11.60% ± 11.17 [p<0.0001]), presenteeism (62.15% ± 20.11 to 34.92% ± 20.61 [p<0.0001]), overall work impairment (69.08% ± 18.86 to 40.73% ± 22.29 [p<0.0001]), overall activity impairment (68.46% ± 18.58 to 36.46% ± 20.79 [p<0.0001]), HAQ score (1.69 ± 0.57 to 0.81 ± 0.61 [p<0.0001]), and FSS score (47.08 ± 9.55 to 27.86 ± 13.43 [p<0.0001]).

Conclusion :
A 6-month course of adalimumab improved work ability, fatigue, and overall health assessments in patients with established RA. Our findings encourage randomized controlled trials investigating the cost-effectiveness and long-term effects of TNF inhibitors on work disability.
The Relation between Accounting Information in Debt Covenants and Operating Leases
Authors: Paik Daniel Gyung H. , van der Laan Smith Joyce A. , Lee Brandon Byunghwan , Yoon Sung Wook 
Published: July 2015

SYNOPSIS
Proposed changes by the FASB and the IASB to lease accounting standards will substantially change the accounting for operating leases by requiring the capitalization of future lease payments. We consider the impact of these changes on firms' debt covenants by examining the frequency of income-statement- versus balance-sheet-based accounting ratios in debt covenants of firms in high and low Off Balance Sheet (OBS) lease industries. Based on debt contracts from the 1996–2009 period, our results provide evidence that lenders focus on balance sheet (income statement) ratios in designing debt covenants for borrowers in low (high) OBS lease industries. Further, the use of balance-sheet- (income-statement-) based covenants falls (rises) faster in high OBS lease industries than in low OBS lease industries as the use of OBS leasing increases. This evidence indicates that OBS operating leases influence lenders' use of accounting information in covenants, suggesting that creditors consider the impact of OBS leases when structuring debt agreements. These results also suggest that the proposed capitalization of OBS leases may not result in firms violating loan covenants but will make the balance sheet a more complete source of information for debt contracting by removing the need for constructive capitalization of OBS leases.
mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function
Authors: Schaffert Steven A. , Loh Christina , Wang Song , Arnold Christopher P. , Axtell Robert C. , Newell Evan W. , Nolan Garry , Ansel K. Mark , Davis Mark M. , Steinman Lawrence , Chen Chang-Zheng 
Published: July 2015

Abstract
Understanding the consequences of tuning TCR signaling on selection, peripheral T cell function, and tolerance in the context of native TCR repertoires may provide insight into the physiological control of tolerance. In this study, we show that genetic ablation of a natural tuner of TCR signaling, mir-181a-1/b-1, in double-positive thymocytes dampened TCR and Erk signaling and increased the threshold of positive selection. Whereas mir-181a-1/b-1 deletion in mice resulted in an increase in the intrinsic reactivity of naive T cells to self-antigens, it did not cause spontaneous autoimmunity. Loss of mir-181a-1/b-1 dampened the induction of experimental autoimmune encephalomyelitis and reduced basal TCR signaling in peripheral T cells and their migration from lymph nodes to pathogenic sites. Taken together, these results demonstrate that tolerance can be modulated by microRNA gene products through the control of opposing activities in T cell selection and peripheral T cell function.
An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development
Authors: Pedros Christophe , Gaud Guillaume , Bernard Isabelle , Kassem Sahar , Chabod Marianne , Lagrange Dominique , Andréoletti Olivier , Dejean Anne S. , Lesourne Renaud , Fournié Gilbert J. , Saoudi Abdelhadi 
Published: July 2015

Abstract
The development of inflammatory diseases depends on complex interactions between several genes and various environmental factors. Discovering new genetic risk factors and understanding the mechanisms whereby they influence disease development is of paramount importance. We previously reported that deficiency in Themis1, a new actor of TCR signaling, impairs regulatory T cell (Treg) function and predisposes Brown–Norway (BN) rats to spontaneous inflammatory bowel disease (IBD). In this study, we reveal that the epistasis between Themis1 and Vav1 controls the occurrence of these phenotypes. Indeed, by contrast with BN rats, Themis1 deficiency in Lewis rats neither impairs Treg suppressive functions nor induces pathological manifestations. By using congenic lines on the BN genomic background, we show that the impact of Themis1 deficiency on Treg suppressive functions depends on a 117-kb interval coding for a R63W polymorphism that impacts Vav1 expression and functions. Indeed, the introduction of a 117-kb interval containing the Lewis Vav1-R63 variant restores Treg function and protects Themis1-deficient BN rats from spontaneous IBD development. We further show that Themis1 binds more efficiently to the BN Vav1-W63 variant and is required to stabilize its recruitment to the transmembrane adaptor LAT and to fully promote the activation of Erk kinases. Together, these results highlight the importance of the signaling pathway involving epistasis between Themis1 and Vav1 in the control of Treg suppressive function and susceptibility to IBD development.
Histone Deacetylase 3 Is Required for T Cell Maturation
Authors: Hsu Fan-Chi , Belmonte Paul J. , Constans Megan M. , Chen Meibo W. , McWilliams Douglas C. , Hiebert Scott W. , Shapiro Virginia Smith 
Published: July 2015

Abstract
Recent thymic emigrants are newly generated T cells that need to undergo postthymic maturation to gain functional competency and enter the long-lived naive T cell pool. The mechanism of T cell maturation remains incompletely understood. Previously, we demonstrated that the transcriptional repressor NKAP is required for T cell maturation. Because NKAP associates with histone deacetylase 3 (HDAC3), we examined whether HDAC3 is also required for T cell maturation. Although thymic populations are similar in CD4-cre HDAC3 conditional knockout mice compared with wild-type mice, the peripheral numbers of CD4+ and CD8+ T cells are dramatically decreased. In the periphery, the majority of HDAC3-deficient naive T cells are recent thymic emigrants, indicating a block in T cell maturation. CD55 upregulation during T cell maturation is substantially decreased in HDAC3-deficient T cells. Consistent with a block in functional maturation, HDAC3-deficient peripheral T cells have a defect in TNF licensing after TCR/CD28 stimulation. CD4-cre HDAC3 conditional knockout mice do not have a defect in intrathymic migration, thymic egress, T cell survival, or homeostasis. In the periphery, similar to immature NKAP-deficient peripheral T cells, HDAC3-deficient peripheral T cells were bound by IgM and complement proteins, leading to the elimination of these cells. In addition, HDAC3-deficient T cells display decreases in the sialic acid modifications on the cell surface that recruit natural IgM to initiate the classical complement pathway. Therefore, HDAC3 is required for T cell maturation.
Acute cold stress and mild hypothermia impact on short-term, working memory and attention
Authors: Paulauskas Henrikas , Brazaitis Marius , Mickevičienė Dalia , Pukėnas Kazimieras , Eimantas Nerijus 
Published: July 2015

The effect of single acute cold water exposure on the cognitive function (short-term, working memory and attention) was examined in 25 male subjects who were exposed to 14 °C cold water (air temperature ~22 °C, rh ~45%) in the semi-recumbent posture (up to the shoulders) until the rectal temperature (T<sub>re</sub>) dropped to 35.5 °C. 6 subjects were excluded from the study, because we do not reach a necessary condition to drop their (T<sub>re</sub>) to 35.5 °C in 170 minutes during a passive cooling procedure. During the cold exposure rectal (T<sub>re</sub>), skin (T<sub>sk</sub>) temperatures, heart rate (HR) were measured and cold strain (CSI) was calculated. A cognitive test battery (EFFECTON-COLD) was administrated two times (randomized): as a control measurement (CONTROL) and after the single acute cold water exposure (COLD). After COLD T<sub>re</sub> and T<sub>sk</sub> significantly decreased (p < 0.05). The average of HR and COLD time was 82.61 ± 4.09 and 93.68 ± 8.66, respectively. The COLD induced CSI resulted as high cold strain (7.02 ± 0.22). The present study manifested that mild hypothermia and high cold strain experienced in humans during acute cold stress, impair memory and attention tests performance in more complex tasks (tasks requiring working memory, attention concentration, sustention and speed of information processing) while simple tasks remain unaffected (tasks requiring short-term memory and attention concentration for fast response).
Effect of biopreparations on seed germination and fungal contamination of winter wheat
Authors: Pekarskas Juozas , Sinkevičienė Jolanta 
Published: July 2015

The aim of the study was to investigate the influence of different biopreparations on the germination energy, germination and fungal infection of ecological winter wheat seeds. Germination energy and germination of winter wheat seeds were determined after 24, 480 and 960 h, while fungal infection after 24 and 960 h of their treatment. In the studies biopreparations Biokal 1 (10 l t<sup>–1</sup>), Biokal 2 (10 l t<sup>–1</sup>), Biojodis (2 l t<sup>–1</sup>) and Penergetic-p for roots (100 ml t<sup>–1</sup>) were used. It was found that the values of germination energy and germination of winter wheat treated with the biopreparations after 480 h increased by 4.45 and 0.62%, as compared to treated seeds after 24 h. After 960 h of treatment the value of germination energy, as compared to seeds treated after 480 h, decreased insignificantly, while the germination of seeds has reliably decreased by 0.84%, as compared to treated seeds after 24 h, the value of germination energy was by 3.45% higher, but no significant decrease in germination was ascertained. Biojodis after 24 h of the treatment was the most reliable in reducing wheat infection with the fungi of <i>Fusarium</i>, <i>Alternaria</i>, while Biokal 1 with <i>Penicillium</i> genera. The studied biopreparations after 960 h were insufficiently effective or had no influence at all on the development and spreading of fungi. The diseases of coleoptiles and roots of winter wheat after 24 h and 960 h were most reliably prevented by the biopreparation Biokal 2.
The impact of different levels of sodium chloride on the quantitative changes of chlorophyll and carotenoids in chloroplasts of Elodea canadensis (Michx. 1803)
Authors: Petjukevičs Aleksandrs , Batjuka Anna , Škute Nataļja 
Published: July 2015

In this study we used spectrophotometry to investigate the effect of negative concentrations of sodium chloride ions on photosynthetic pigments in <i>Elodea canadensis</i> (Michx. 1803). The concentrations of pigments, carotenoids, chlorophyll a and chlorophyll b, in plant leaves provide information about the physiological state of plants and were determined using a spectrophotometer. Quantity and dynamics analyses of photosynthetic pigments are effective methods which allow determining changes in metabolites of plant cells even at insignificant cellular damage. During this research photosynthetic pigments in leaves were obtained at the different sodium chloride levels: 0.0, 0.025, 0.05, 0.1, 0.5 and 1.0 M. The results of this research indicate that these types of stressors at high concentrations: 0.1, 0.5 and 1.0 M after a prolonged time of impact on plant leaves lead to a decrease of photosynthetic pigments and inhibit growth and development of a plant as a whole.
Vulcanization Kinetics and Mechanical Properties of Ethylene Propylene Diene Monomer Thermal Insulation
Authors: Fathurrohman Mohamad Irfan , Maspanger Dadi Rusadi , Sutrisno Sutrisno 
Published: July 2015

The vulcanization kinetics of Ethylene-propylene diene monomer (EPDM) rubber thermal insulation was studied by using rheometer under isothermal condition at different temperatures. The rheometry analysis was used to determining the cure kinetic parameters and predicting the cure time of EPDM thermal insulation. The experimental results revealed that the curing curves of EPDM thermal insulation were marching and the optimum curing time decreased with increasing the temperature. The kinetic parameters were determined from the autocatalytic model showed close fitting with the experimental results, indicating suitability of autocatalytic model in characterizing the cure kinetics. The activation energy was determined from the autocatalytic model is 46.3661 kJ mol-1. The cure time were predicted from autocatalytic model and the obtained kinetic parameter by using the relationship among degree of conversion, cure temperature, and cure time. The predictions of cure time provide information for the actual curing characteristic of EPDM thermal insulation. The mechanical properties of EPDM thermal insulation with different vulcanization temperatures showed the same hardness, tensile strength and modulus at 300%, except at temperature 70 °C, while the elongation at breaking point decreased with increasing temperature of vulcanization. © 2015 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)