bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Constitutionalism and the Data Economy
Authors: Luna Ferlanda , Maxhelaku Armela 
Published: August 2024

AbstractThe recent development of virtual data processing has brought about an entirely new perspective on the issues of regulation and the access to information. Information, in turn, has become a crucial component of the changing dynamics of the global market. It is crucial to address the potential of insurgent digital constitutionalism in establishing legal frameworks that ensure Internet security for both users and online platform managers, including private companies and government agencies. This applies to the usage and dissemination of data. With the development of technology, data management has become an important asset in the market. Considering these conditions, it is essential to establish legal frameworks in order to regulate the newly assigned responsibilities pertaining to information.
The Inclusivity of Art in City Space. Activities of Researchers from the University of Lodz to Support People with Sensory Disabilities. A Case Study from Lodz (Poland)
Authors: Pawłowska Aneta , Drozdowski Adam , Milerowska Magdalena , Długosz Paulina 
Published: August 2024

Abstract Projects dedicated to addressing the accessibility of art for visually impaired individuals have been conducted at the Institute of Art History, University of Lodz, since 2013. This chapter focuses on four projects realized in collaboration with local museums, all aiming to support the full participation of people with sensory disabilities in culture. These projects employ digital technology, as well as dedicated typhlographics, Braille books, and spatial objects. Additionally, lectures, meetings, trips, and movie showings are interpreted into sign language. Such initiatives align with the positive changes brought by the Polish Accessibility Act. The most significant projects include “Lodz Art Against the Background of European Art. Excluded/Included” (2019–2022) and “Friendly City. Supporting the Independence of Visually Impaired People in Using the Public Transport Network in Lodz,” which includes an application for locational information and local architectural monuments (2021–2024). Both projects are funded by the National Center for Research and Development. Drawing from years of research experience, this chapter presents various methods and forms of using both tactile and digital tools to support audio description.
Suborbital Space Tourism: Doozy Experiences Beyond Earth
Authors: Jaskari Minna-Maarit , Jauffret Marie-Nathalie , Kauppinen-Räisänen Hannele 
Published: August 2024

AbstractThis chapter delves into the experiences of actual space travelers, focusing on their experiences along the journey. The underlying premise is that the experiences occurring in various phases of the journey—pre, during, and after—each play a crucial role in shaping the holistic travel experience. In order to gain in-depth insights regarding these experiences, a qualitative study was designed using mixed methods comprising three one-to-one interviews, analysis of published interviews with six space travel astronauts, and archival data. The study contributes with insights into the unique circumstances of space travel and lived experiences of such journeys. It also introduces the concept of “doozy tourism” to illustrate the specific nature of space tourism, which is here characterized as a niche of luxury tourism. Finally, it shows how experiences within space tourism are divided into four phases. The study also holds managerial implications for luxury space tourism.
The Commercial Aspects of Navigation Satellites: A Systematic Literature Review
Authors: Hassinen Sofia , Ojala Arto , Kuusniemi Heidi 
Published: August 2024

AbstractThis paper aims to examine the state-of-the-art concerning the commercial aspects of navigation satellite systems. The objective of this systematic literature review is to gather existing literature, map the current state of knowledge, and propose new research avenues regarding the commercial aspects of navigation satellites. To achieve these goals, we conducted a systematic literature review, reviewing 32 papers on navigation satellite systems and their application for commercial usage. Based on the literature, we identify six themes and elaborate on how these themes contribute to our understanding of the topic. The research indicates a scarcity of comprehensive studies on the commercial aspects of satellite navigation-enabled location-based services. Therefore, further investigation is necessary to identify and understand the business models and ecosystems of companies operating in this industry.
Isotropization of a longitudinally expanding system of scalar fields in the 2PI formalism
Authors: Gelis François , Hauksson Sigtryggur 
Published: August 2024

Abstract
Motivated by isotropization of QCD matter in the initial stages of heavy-ion collisions, we consider a system of scalar fields that undergoes a boost invariant longitudinal expansion. We use the framework of the two-particle irreducible (2PI) effective action, which is close to the underlying quantum field theory, and resum self-energy corrections up to three loops. The resulting 2PI equations of motion are expressed in terms of the Milne coordinates to account for longitudinal expansion. By solving numerically these equations of motion, we can extract the occupation density and the effective mass generated by in-medium interactions. At the largest values of the coupling considered in this study, we observe the onset of isotropization both in the occupation number and in the momentum dependence of the effective mass.
VEGFD signaling balances stability and activity-dependent structural plasticity of dendrites
Authors: Aksan Bahar , Kenkel Ann-Kristin , Yan Jing , Sánchez Romero Javier , Missirlis Dimitris , Mauceri Daniela 
Published: August 2024

AbstractMature neurons have stable dendritic architecture, which is essential for the nervous system to operate correctly. The ability to undergo structural plasticity, required to support adaptive processes like memory formation, is still present in mature neurons. It is unclear what molecular and cellular processes control this delicate balance between dendritic structural plasticity and stabilization. Failures in the preservation of optimal dendrite structure due to atrophy or maladaptive plasticity result in abnormal connectivity and are associated with various neurological diseases. Vascular endothelial growth factor D (VEGFD) is critical for the maintenance of mature dendritic trees. Here, we describe how VEGFD affects the neuronal cytoskeleton and demonstrate that VEGFD exerts its effects on dendrite stabilization by influencing the actin cortex and reducing microtubule dynamics. Further, we found that during synaptic activity-induced structural plasticity VEGFD is downregulated. Our findings revealed that VEGFD, acting on its cognate receptor VEGFR3, opposes structural changes by negatively regulating dendrite growth in cultured hippocampal neurons and in vivo in the adult mouse hippocampus with consequences on memory formation. A phosphoproteomic screening identified several regulatory proteins of the cytoskeleton modulated by VEGFD. Among the actin cortex-associated proteins, we found that VEGFD induces dephosphorylation of ezrin at tyrosine 478 via activation of the striatal-enriched protein tyrosine phosphatase (STEP). Activity-triggered structural plasticity of dendrites was impaired by expression of a phospho-deficient mutant ezrin in vitro and in vivo. Thus, VEGFD governs the equilibrium between stabilization and plasticity of dendrites by acting as a molecular brake of structural remodeling.
Uncovering key steps in FGF12 cellular release reveals a common mechanism for unconventional FGF protein secretion
Authors: Biadun Martyna , Sochacka Martyna , Kalka Marta , Chorazewska Aleksandra , Karelus Radoslaw , Krowarsch Daniel , Opalinski Lukasz , Zakrzewska Malgorzata 
Published: August 2024

AbstractFGF12 belongs to a subfamily of FGF proteins called FGF homologous factors (FHFs), which until recently were thought to be non-signaling intracellular proteins. Our recent studies have shown that although they lack a conventional signal peptide for secretion, they can reach the extracellular space, especially under stress conditions. Here, we unraveled that the long “a” isoform of FGF12 is secreted in a pathway involving the A1 subunit of Na(+)/K(+) ATPase (ATP1A1), Tec kinase and lipids such as phosphatidylinositol and phosphatidylserine. Further, we showed that the short “b” isoform of FGF12, which binds ATP1A1 and phosphatidylserine less efficiently, is not secreted from cells. We also indicated regions in the FGF12a protein sequence that are crucial for its secretion, including N-terminal fragment and specific residues, and proposed that liquid-liquid phase separation may be important in this process. Our results strongly suggest that the mechanism of this process is very similar for all unconventionally secreted FGF proteins.
Glycaemic control is still central in the hierarchy of priorities in type 2 diabetes management
Authors: Khunti Kamlesh , Zaccardi Francesco , Amod Aslam , Aroda Vanita R. , Aschner Pablo , Colagiuri Stephen , Mohan Viswanathan , Chan Juliana C. N. 
Published: August 2024

AbstractA panel of primary care and diabetes specialists conducted focused literature searches on the current role of glycaemic control in the management of type 2 diabetes and revisited the evolution of evidence supporting the importance of early and intensive blood glucose control as a central strategy to reduce the risk of adverse long-term outcomes. The optimal approach to type 2 diabetes management has evolved over time as the evidence base has expanded from data from trials that established the role of optimising glycaemic control to recent data from cardiovascular outcomes trials (CVOTs) demonstrating organ-protective effects of newer glucose-lowering drugs (GLDs). The results from these CVOTs were derived mainly from people with type 2 diabetes and prior cardiovascular and kidney disease or multiple risk factors. In more recent years, earlier diagnosis in high-risk individuals has contributed to the large proportion of people with type 2 diabetes who do not have complications. In these individuals, a legacy effect of early and optimal control of blood glucose and cardiometabolic risk factors has been proven to reduce cardiovascular and kidney disease events and all-cause mortality. As there is a lack of RCTs investigating the potential synergistic effects of intensive glucose control and organ-protective effects of newer GLDs, this article re-evaluates the evolution of the scientific evidence and highlights the importance of integrating glycaemic control as a pivotal early therapeutic goal in most people with type 2 diabetes, while targeting existing cardiovascular and kidney disease. We also emphasise the importance of implementing multifactorial management using a multidisciplinary approach to facilitate regular review, patient empowerment and the possibility of tailoring interventions to account for the heterogeneity of type 2 diabetes.
Graphical Abstract
Camera-based mapping in search-and-rescue via flying and ground robot teams
Authors: Esteves Henriques Bernardo , Baglioni Mirko , Jamshidnejad Anahita 
Published: August 2024

AbstractSearch and rescue (SaR) is challenging, due to the unknown environmental situation after disasters occur. Robotics has become indispensable for precise mapping of the environment and for locating the victims. Combining flying and ground robots more effectively serves this purpose, due to their complementary features in terms of viewpoint and maneuvering. To this end, a novel, cost-effective framework for mapping unknown environments is introduced that leverages You Only Look Once and video streams transmitted by a ground and a flying robot. The integrated mapping approach is for performing three crucial SaR tasks: localizing the victims, i.e., determining their position in the environment and their body pose, tracking the moving victims, and providing a map of the ground elevation that assists both the ground robot and the SaR crew in navigating the SaR environment. In real-life experiments at the CyberZoo of the Delft University of Technology, the framework proved very effective and precise for all these tasks, particularly in occluded and complex environments.
Investigating laser and ultrasonic welding of pouch cell multi-foil current collectors for electric vehicle battery fabrication
Authors: Kumar Nikhil , Pamarthi Venkat Vivek , Das Abhishek 
Published: August 2024

AbstractThe escalating necessity for more efficient and defect-free joining of ‘ultra-thin foil collectors-to-tabs’ in electric vehicle (EV) Li-ion pouch cells motivates this study. The prevalent ultrasonic welding (USW) method for these joint types, faces limitations such as design constraints and access requirements, laser welding (LW) emerges as a promising alternative offering flexibility, one-side access and faster speeds with efficient heat input. This study aims to investigate the feasibility of LW as a viable alternative to USW for joining current collectors-to-tab joints. It compares the mechanical, metallurgical, electrical and thermal analysis of the joints to evaluate both welding techniques for joint defects. The comparison of solid-state material mixing during USW and the intermixing of aluminium (Al) and copper (Cu) during fusion LW using EDX analysis presents interesting observations in the study. The USW generates a thin transition layer with intermetallic compounds (IMCs) attributed to the diffusion of Cu into the Al matrix during joining, which is comparatively lower as in the case of LW with higher material mixing with brittle IMCs like Al2Cu and Al4Cu9. However, the joint strength of LW is comparatively lower than the USW joint attributed to the reduced fusion zone area. Furthermore, from the electrical contact resistance and the joint temperature analysis, it was found that the resistance and temperature vary by as much as 13% and 6%, respectively, for the 50 A and 75 A passing currents when the USW is replaced with the LW process.
Detection of Usutu virus in a house martin bug Oeciacus hirundinis (Hemiptera: Cimicidae): implications for virus overwintering in a temperate zone
Authors: Šikutová Silvie , Mendel Jan , Mravcová Kristína , Kejíková Romana , Hubálek Zdeněk , Kampen Helge , Rudolf Ivo 
Published: August 2024

AbstractThe family Cimicidae comprises ectoparasites feeding exclusively on the blood of endothermic animals. Cimicid swallow bugs specifically target swallow birds (Hirundinidae) and their nestlings in infested nests. Bugs of the genus Oeciacus are commonly found in mud nests of swallows and martins, while they rarely visit the homes of humans. Although—unlike other cimicid species—the house martin bug Oeciacus hirundinis has never been reported as a vector of zoonotic pathogens, its possible role in arbovirus circulation in continental Europe is unclear. Samples of O. hirundinis were therefore collected from abandoned house martin (Delichon urbicum) nests in southern Moravia (Czech Republic) during the 2021/2022 winter season and checked for alpha-, flavi- and bunyaviruses by RT-PCR. Of a total of 96 pools consisting of three adult bugs each, one pool tested positive for Usutu virus (USUV)-RNA. Phylogenetic analysis showed that the virus strain was closely related to Italian and some Central European strains and corresponded to USUV lineage 5. The detection of USUV in O. hirundinis during wintertime in the absence of swallows raises the question for a possible role of this avian ectoparasite in virus overwintering in Europe.
Comparison of elements and state-variable transfer methods for quasi-incompressible material behaviour in the particle finite element method
Authors: Schewe Markus , Bartel Thorsten , Menzel Andreas 
Published: August 2024

Abstract
The Particle Finite Element Method (PFEM) is attractive for the simulation of large deformation problems, e.g. in free-surface fluid flows, fluid–structure interaction and in solid mechanics for geotechnical engineering and production processes. During cutting, forming or melting of metal, quasi-incompressible material behaviour is often considered. To circumvent the associated volumetric locking in finite element simulations, different approaches have been proposed in the literature and a stabilised low-order mixed formulation (P1P1) is state-of-the-art. The present paper compares the established mixed formulation with a higher order pure displacement element (TRI6) under 2d plane strain conditions. The TRI6 element requires specialized handling, involving the deletion and re-addition of edge-mid-nodes during triangulation remeshing. The robustness of both element formulations is analysed along with different state-variable transfer schemes, which are not yet widely discussed in the literature. The influence of the stabilisation factor in the P1P1 element formulation is investigated, and an equation linking this factor to the Poisson ratio for hyperelastic materials is proposed.
Comparison of diabetic retinopathy screening between hospital-based multidisciplinary and general practice-based settings: insights from a regional study in Italy
Authors: Olivieri Chiara , Salato Mattia , Campanella Alessandra , Marolo Paola , Parisi Guglielmo , Neri Giovanni , Toro Mario Damiano , Scarmozzino Antonio , Broglio Fabio , Borrelli Enrico , Reibaldi Michele 
Published: August 2024

Abstract

Purpose
To compare diabetic retinopathy screening among patients with type 1 or type 2 diabetes under care in two distinct setups: hospital-based multidisciplinary and general practice-based.

Materials and methods
In this retrospective observational case series, we collected data from a total of 133 diabetic patients: subjects from the hospital-based multidisciplinary setting were referred by the diabetologist and screened by an ophthalmologist using the Optomed Aurora IQ fundus camera. These patients were compared with those who underwent DR screening arranged through a general practice-based setting.

Results
The proportion of patients treated with insulin was higher in the hospital-based multidisciplinary group, both considering the totality patients and those affected by type 2 diabetes (71.6% vs. 32.2%; p < 0.001, and 58.8% vs. 31.0%; p = 0.004 respectively). Patients from the hospital-based multidisciplinary group had a longer mean diabetes duration (19.6 vs 14.9 years, p < 0.001), underwent DR screening more frequently in the previous three years (2.9 vs 1.4, p < 0.001), the mean time between two DR screenings was shorter (14.6 vs 77.9 weeks, p < 0.001), and DR was detected more frequently (32,4% vs 13.5%; p = 0.011).

Conclusion
We were able to demonstrate that patients screened in the multidisciplinary center, which had characteristics predisposing to a higher risk of DR, were more likely to be diagnosed with DR on time, with a higher mean number of DR screenings and a shorted interval between diabetic and ophthalmological assessments.
Nivolumab plus chemotherapy in patients with HER2-negative, previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: 3-year follow-up of the ATTRACTION-4 randomized, double-blind, placebo-controlled, phase 3 trial
Authors: Boku Narikazu , Omori Takeshi , Shitara Kohei , Sakuramoto Shinichi , Yamaguchi Kensei , Kato Ken , Kadowaki Shigenori , Tsuji Kunihiro , Ryu Min-Hee , Oh Do-Youn , Oh Sang Cheul , Rha Sun Young , Lee Keun-Wook , Chung Ik-Joo , Sym Sun Jin , Chen Li-Tzong , Chen Jen-Shi , Bai Li-Yuan , Nakada Takashi , Hagihara Shunsuke , Makino Reina , Nishiyama Eiji , Kang Yoon-Koo 
Published: August 2024

Abstract
Background
Nivolumab + chemotherapy is now a standard of care for HER2-negative, previously untreated, unresectable or recurrent gastric/gastroesophageal junction cancer (advanced gastric cancer), but long-term follow-up data of clinical trials are limited.

Methods
ATTRACTON-4 was a phase 3, double-blind, placebo-controlled trial in Japan, South Korea, and Taiwan. Patients were randomized to either nivolumab or placebo, both combined with the physician’s choice of SOX (oral S-1 [tegafur–gimeracil–oteracil potassium] + oxaliplatin) or CAPOX (capecitabine + oxaliplatin). We report the primary endpoints—centrally assessed progression-free survival (PFS) and overall survival (OS)—and landmark analyses of OS among patients alive using 3-year follow-up data.

Results
At the cutoff date (May 10, 2021), 17/359 patients in the nivolumab + chemotherapy group and 6/358 in the placebo + chemotherapy group were continuing study treatment. PFS (centrally assessed) was longer in the nivolumab + chemotherapy group (median 10.94 vs. 8.48 months; hazard ratio [HR] 0.67, 95% confidence interval [CI] 0.55–0.82). Although OS did not differ between the two groups (median 17.45 vs. 17.15 months; HR 0.89, 95% CI 0.75–1.05), the landmark analysis of OS, calculating HRs at each landmark time point (every month), was getting numerically better in the nivolumab + chemotherapy group over time. Approximately 80% of patients who achieved complete response in the nivolumab + chemotherapy group were alive at 3 years. No new safety signals or major late-onset select treatment-related adverse events were observed for nivolumab + chemotherapy.

Conclusion
This 3-year follow-up of ATTRACTION-4 confirmed the long-term clinical benefit and manageable safety of nivolumab + chemotherapy in patients with previously untreated advanced gastric cancer.

Trial registration
NCT02746796
Disentangling ground-nest predation rates through an artificial nests experiment in an area with western capercaillie (Tetrao urogallus) presence: martens are the key
Authors: Palencia Pablo , Barroso Patricia 
Published: August 2024

AbstractThe western capercaillie (Tetrao urogallus) is a species of conservation concern that has been experiencing a severe decline in many regions of Europe. The poor breeding success rather than mortality of full-grown birds has been suggested to be responsible for its decline, been the nest loss a potential driver of the low productivity (number of chicks per female and year) of capercaillie. Working in a capercaillie population in the Pyrenees, we aimed to provide further insights into nest predation by monitoring 82 artificial nests (58 of them with camera traps), and estimating the population density of predators using camera traps and applying random encounter model and camera trap distance sampling. Pine/stone martens -Martes foina, Martes martes- were the species with higher nest predation rates (23%) despite being the less abundant (0.49 ind/km2), followed by foxes -Vulpes vulpes- (11%) and a population density of 3.37 ind/km2, and wild boar -Sus scrofa- (4%) and 6.95 ind·km− 2; predators could not be identified at 27% of the events. After fitting statistical models on the nest predation data, we observed that the martens’ encounter rate (i.e. number of martens detected per camera and day) and the altitude had a positive significant effect on the artificial nest predation probability. While caution is recommended in artificial nest experiments, our results are valuable highlighting the importance of martens and red foxes when addressing nest predation to promote the breeding success and population recovery of western capercaillie populations.