bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src
Authors: Ishibashi Kenichi , Fukumoto Yasunori , Hasegawa Hitomi , Abe Kohei , Kubota Shoichi , Aoyama Kazumasa , Kubota Sho , Nakayama Yuji , Yamaguchi Naoto 
Published: December 2012

Summary
The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR)/ErbB1, HER2/ErbB2, ErbB3 and ErbB4, and plays roles in signal transduction at the plasma membrane upon ligand stimulation. Stimulation with neuregulin-1 (NRG-1) cleaves ErbB4 and releases the ErbB4 intracellular domain (4ICD) that translocates into the nucleus to control gene expression. However, little is known about the regulation of 4ICD nuclear signaling through tyrosine phosphorylation. We show here that 4ICD nuclear signaling is antagonized by EGF-induced c-Src activation through EGFR. Generation of 4ICD by NRG-1 leads to increased levels of trimethylated histone H3 on lysine 9 (H3K9me3) in a manner dependent on the nuclear accumulation of 4ICD and its tyrosine kinase activity. Once EGF activates c-Src downstream of EGFR concomitantly with NRG-1-induced ErbB4 activation, c-Src associates with phospho-Tyr950 and phospho-Tyr1056 on 4ICD, thereby decreasing nuclear accumulation of 4ICD and inhibiting an increase of H3K9me3 levels. Moreover, 4ICD-induced transcriptional repression of the human telomerase reverse transcriptase (hTERT) is inhibited by EGF–EGFR–Src signaling. Thus, our findings reveal c-Src-mediated inhibitory regulation of ErbB4 nuclear signaling upon EGFR activation.
Engineering Trust: Reciprocity in the Production of Reputation Information
Authors: Bolton Gary , Greiner Ben , Ockenfels Axel 
Published: December 2012

Reciprocity in feedback giving distorts the production and content of reputation information in a market, hampering trust and trade efficiency. Guided by feedback patterns observed on eBay and other platforms, we run laboratory experiments to investigate how reciprocity can be managed by changes in the way feedback information flows through the system, leading to more accurate reputation information, more trust, and more efficient trade. We discuss the implications for theory building and for managing the redesign of market trust systems. This paper was accepted by Teck Ho, decision analysis.
Wahrnehmung – Experiment – Erinnerung. Erfahrung und Topik in Prosaromanen der Frühen Neuzeit
Authors: Friedrich Udo 
Published: December 2012

Abstract
This essay inquires into the semantics of the term “experience” in a selection of prose novels from the early modern period. Against the background of a complex history of discourses about experience, ultimately leading to a fully articulated concept of “empiricism” and “experiment”, the author traces the term’s usages in Hartlieb’s ‘Alexander’, in the novel ‘Fortunatus’ as well as in Wickram’s ‘Of Good and Bad Neighbours’. Furthermore, he elaborates those cultural topoi of experience that are based principally on an understanding of “memory” and “adaptation”. As a result, the author is able to show, that all three texts place varying emphases on the topics of experience.
Near-Infrared Imaging in Intravenous Cannulation in Children: A Cluster Randomized Clinical Trial
Authors: Cuper Natascha J. , de Graaff Jurgen C. , Verdaasdonk Rudolf M. , Kalkman Cor J. 
Published: December 2012

OBJECTIVE:
Intravenous cannulation is a widespread medical procedure that can be difficult in children. Visualization of veins with near-infrared (NIR) light might support intravenous cannulation. Therefore, we investigated the effectiveness of an NIR vascular imaging system (VascuLuminator) in facilitating intravenous cannulation in children in the operating room.

METHODS:
This was a pragmatic, cluster randomized clinical trial in all consecutive children (0–18 years) scheduled for elective surgery and in need of intravenous cannulation at a tertiary pediatric referral hospital. Daily operating rooms (770 patients) were randomized for allocation of the VascuLuminator or control group. The primary outcome was success at first attempt; the secondary outcome was time to successful cannulation.

RESULTS:
Success at first attempt was 70% (171/246) with and 71% (175/245) without the use of the VascuLuminator (P = .69). Time to successful cannulation was 162 (±14) seconds and 143 (±15) seconds respectively (P = .26). In 83.3%, the vein of first choice was visible with the VascuLuminator.

CONCLUSIONS:
Although it was possible to visualize veins with NIR in most patients, the VascuLuminator did not improve success rate or time to obtain intravenous cannulation. There are 3 possible explanations for this result: first, it could be that localization of the vein is not the main problem, and therefore visualization is not a solution; second, the type of system used in this study could be less than optimal; and, third, the choice of the patient population in this study could be inappropriate.
Longitudinal Associations Between Teen Dating Violence Victimization and Adverse Health Outcomes
Authors: Exner-Cortens Deinera , Eckenrode John , Rothman Emily 
Published: December 2012

OBJECTIVE:
To determine the longitudinal association between teen dating violence victimization and selected adverse health outcomes.

METHODS:
Secondary analysis of Waves 1 (1994–1995), 2 (1996), and 3 (2001–2002) of the National Longitudinal Study of Adolescent Health, a nationally representative sample of US high schools and middle schools. Participants were 5681 12- to 18-year-old adolescents who reported heterosexual dating experiences at Wave 2. These participants were followed-up ∼5 years later (Wave 3) when they were aged 18 to 25. Physical and psychological dating violence victimization was assessed at Wave 2. Outcome measures were reported at Wave 3, and included depressive symptomatology, self-esteem, antisocial behaviors, sexual risk behaviors, extreme weight control behaviors, suicidal ideation and attempt, substance use (smoking, heavy episodic drinking, marijuana, other drugs), and adult intimate partner violence (IPV) victimization. Data were analyzed by using multivariate linear and logistic regression models.

RESULTS:
Compared with participants reporting no teen dating violence victimization at Wave 2, female participants experiencing victimization reported increased heavy episodic drinking, depressive symptomatology, suicidal ideation, smoking, and IPV victimization at Wave 3, whereas male participants experiencing victimization reported increased antisocial behaviors, suicidal ideation, marijuana use, and IPV victimization at Wave 3, controlling for sociodemographics, child maltreatment, and pubertal status.

CONCLUSIONS:
The results from the present analyses suggest that dating violence experienced during adolescence is related to adverse health outcomes in young adulthood. Findings from this study emphasize the importance of screening and offering secondary prevention programs to both male and female victims.
In Utero Exposure to Ischemic-Hypoxic Conditions and Attention-Deficit/Hyperactivity Disorder
Authors: Getahun Darios , Rhoads George G. , Demissie Kitaw , Lu Shou-En , Quinn Virginia P. , Fassett Michael J. , Wing Deborah A. , Jacobsen Steven J. 
Published: December 2012

OBJECTIVE:To examine the association between ischemic-hypoxic conditions (IHCs) and attention-deficit/hyperactivity disorder (ADHD) by gestational age and race/ethnicity.METHODS:Nested case-control study using the Kaiser Permanente Southern California (KPSC) medical records. The study cohort included children aged 5 to 11 years who were delivered and cared for in the KPSC between 1995 and 2010 (N = 308 634). Case children had a diagnosis of ADHD and received ≥2 prescriptions specific to ADHD during the follow-up period. For each case, 5 control children were matched by age at diagnosis. Exposures were defined by using International Classification of Diseases, Ninth Revision codes. A conditional regression model was used to estimate adjusted odds ratios (ORs).RESULTS:Among eligible children, 13 613 (4.3%) had a diagnosis of ADHD. Compared with control children, case children were more likely to be male and of white or African American race/ethnicity. Case children were more likely to be exposed to IHCs (OR = 1.16, 95% confidence interval [CI] 1.11–1.21). When stratified by gestational age, cases born at 28 to 33, 34 to 36, and 37 to 42 weeks of gestation, were more likely to be exposed to IHCs (ORs, 1.6 [95% CI 1.2–2.1], 1.2 [95% CI 1.1–1.3], and 1.1 [95% CI 1.0–1.2], respectively) compared with controls. IHC was associated with increased odds of ADHD across all race/ethnicity groups.CONCLUSIONS:These findings suggest that IHCs, especially birth asphyxia, respiratory distress syndrome, and preeclampsia, are independently associated with ADHD. This association was strongest in preterm births.
Nyelezett supraclavicularis osteocutan szigetlebeny alkalmazása tracheostoma zárására
Authors: Agócs László , Lévay Bernadett , Boér András , Elek Jenő 
Published: December 2012

AbsztraktA szerzők egy 52 éves nőbeteg esetét ismertetik, akinél életet veszélyeztető légzési nehézséget okozó struma miatt sürgős tracheostomia történt. A kompressziót okozó pajzsmirigy a későbbiekben eltávolításra került. Mivel az atípusos tracheostoma spontán nem záródott, rekonstrukciót terveztek. Tekintettel arra, hogy a légcső elülső falának folytonosságát egy részen pótolni kellett, supraclavicularis osteocutan lebeny mellett döntöttek. Az a. supraclavicularist felkeresve, a váll területéről vett szigetlebenyt preparáltak, és a clavicula processus coracoideusáról levésett vékony csontdarabbal együtt subcutan tunnelen a defektusba forgatták. A csontdarabot a trachea defektusába öltötték, a lebenyt a stoma helyére fektették. A donorterületet primeren zárták. Az irodalom áttekintése, valamint saját esetük kapcsán javasolják a lebeny szélesebb körű alkalmazását, hangsúlyozva, hogy kiváló esztétikai eredményt ad, és a donorterület zárásához nincs szükség bőrátültetésre.
Egyedi műtéti megoldás fiatal férfi betegen manubriumresectio után Grade II chondrosarcomában
Authors: Kocsis Ákos , Agócs László , Kostic Szilárd , Török Klára , Molnár Miklós , Lévay Bernadett , Tóth Ferenc , Vadász Pál , Rényi-Vámos Ferenc 
Published: December 2012

Absztrakt

Bevezetés: A primer malignus csontdaganatok kb. 30%-a chondrosarcoma, leginkább az elülső mellkasfalon jelentkeznek. Azoknak a betegeknek, akik megfelelő sebészi kezelést kapnak, 97%-os a 10 éves túlélési rátájuk. Ezenfelül fontos a terhelhetőség és a légzési funkció megőrzése, nem utolsósorban pedig az esztétikai eredmény. Beteg: A szerzők egy 44 éves férfi beteg esetét ismertetik, aki sportmasszőrként dolgozott, és a manubrium sterni Grade II chondrosarcomája miatt került műtétre. A beavatkozás során a sternum érintett része szélesen az épben kimetszésre került, a helyreállítás során a Dual Mesht bal oldali pectoralis major lebennyel fedték, valamint egyedi megoldásként a semitendinosus és -gracilis izmok inát felhasználva fixáltak két claviculát egymáshoz, ezáltal nagyfokú stabilitást adva a mellkasfalnak, és -visszaadva a felső végtag, illetve a vállöv terhelhetőségét. Eredmény: Eseménytelen posztoperatív szak után a beteg hamar felépült, és gyorsan visszatérhetett korábbi, a vállövet jelentősen igénybe vevő munkájához. Következtetés: A szerzők nem találtak hasonló műtéti eljárást az irodalomban, és ajánlják alkalmazását hasonló esetekben.
Effects of The Men’s Program on U.S. Army Soldiers’ Intentions to Commit and Willingness to Intervene to Prevent Rape: A Pretest Posttest Study
Authors: Foubert John D. , Masin Ryan C. 
Published: December 2012

Noncommissioned male officers in the U.S. Army stationed in Germany were trained to present a 1-hour rape prevention workshop—The Men’s Program—to 237 enlisted male soldiers. A comparison group of 244 male soldiers received a briefing focused on reducing the individual’s risk for experiencing sexual assault, discussion of myths and facts about sexual assault, and how to avoid being accused of sexual assault. Participants in The Men’s Program experienced significant change in the predicted direction for bystander willingness to help, bystander efficacy, rape myth acceptance, likelihood of raping, and likelihood of committing sexual assault with low to medium effect sizes. Comparison group participants experienced no effect on these variables except for a significant decline in rape myth acceptance with a very low effect size.Between-group differences pointed to the efficacy of The Men’s Program. Implications of these results for rape prevention programming in the military are discussed.
Using Gold-based Indonesian Crude Price (ICP) in Economical Evaluation of Field Development Plan
Authors: Nurhadi Sudirman Rasmin 
Published: December 2012

ABSTRACT
Both oil and gold are commodities with price in US Dollars, but they choose different path in trend figure. While gold has been showing great stability over the years, oil keeps changing in price level. Oil price movements have distorted measurement of economic variables measured in dollar values. In economical evaluation for oil and gas field development projects longer than one year, oil price is one of the most critical assumptions. This paper is trying to solve whether: gold is more stable than paper currenciesgold equivalency is more reliable way to project future costs/pricethe gold-based oil price can be applied in current economical evaluation template of field development plan
Considering crude oil prices are moving dynamically for last decade, this paper exercise the model to determine realistic oil price assumption by using more stable "currencies", thus it can provide more reliable and accurate economical evaluation. It shows that gold-based crude-oil price is preferable indampening or mitigating: effect of dynamic oil price natureimpact of inflationrisks of paper-based currency fluctuationdiscount rate requirement
Using case study of Indonesian Production Sharing Contract (PSC) fiscal terms, the model provides more simple economical evaluation, resulting real net cashflow of field development plan. Demonstrating using gold equivalency instead of paper-based currencies provides more consistent and reliable nominal revenue in both perspective of PSC Contractor and Government.
Association of Nevirapine Levels with Rash or Hepatotoxicity Among HIV-Infected Thai Women
Authors: Ratanasuwan Winai , Jariyasethpong Tavatchai , Anekthananon Thanomsak , Intalapaporn Poj , Kongpatanakul Supornchai , Pongnarin Piyapat , Wasinrapee Punneeporn , Chantharojwong Nartlada , Raengsakulrach Boonyos , Peters Philip J , McNicholl Janet , McConnell Michelle S , Weidle Paul J 
Published: December 2012

Background:We performed a nested case-control study of Thai women prescribed nevirapine-based antiretroviral therapy (ART) to determine if development of rash or hepatotoxicity during the first 24 weeks of treatment is associated with plasma nevirapine concentrations.Method:From May 2005-January 2007, we enrolled 217 women initiating nevirapine-based ART in Thailand. Cases (n = 54) were women who during the first 24 weeks of treatment with nevirapine developed rash (any grade, n = 42) or hepatotoxicity (≥grade 2, n = 22, [10 had both]). Controls were the next enrolled woman who was confirmed not to meet the case definition during the first 24 weeks. Nevirapine concentrations after the two week lead-in dose of 200 mg once daily were compared between cases and controls by Wilcoxon rank-sum tests.Results:We found no difference in Week 2 pre-dose nevirapine concentrations: cases median = 3,528 ng/mL (n = 24), controls median = 3,150ng/mL (n = 30), p = 0.5. Cases had higher post-dose nevirapine concentrations (median = 6,150 ng/mL, n = 21) than controls (median = 4,746 ng/mL, n = 20, p = 0.02). When limited to cases who developed a rash at Week 2, we found no differences in the pre-dose (median = 3,270 ng/mL, n = 12, p = 0.9) or post-dose nevirapine concentration (median = 5,443 ng/mL, n = 9, p = 0.4) compared with controls.Conclusions:We cannot conclude definitively that nevirapine concentrations at two weeks of therapy are associated with rash or hepatotoxicity. It is unlikely that therapeutic drug monitoring at that time will improve identification of patients at risk for rash or hepatotoxicity.
Relevance of GASB No. 34 to Financial Reporting by Municipal Governments
Authors: Pridgen Annette K. , Wilder W. Mark 
Published: December 2012

SYNOPSIS
The Governmental Accounting Standards Board issued Statement No. 34, creating a new accrual-based financial reporting model. This study examines whether information from this model is associated with the default risk (a proxy for fiscal distress) of municipal governments and whether this information is incremental to that provided by the fund-based, modified-accrual reporting model. Ordered logistic regressions are used to analyze financial data from 2005 for a sample of 409 municipalities that participated in the Government Finance Officers Association award program. This study extends the work of Plummer et al. (2007) to municipal governments. In addition to the financial position indicator variable (total net assets/total revenues) examined by Plummer et al. (2007), this study provides evidence of the relevance of three other financial indicators (change in net assets/total net assets; total liabilities/total assets; and current assets/current liabilities). We also find that these accrual-based indicators provide information incremental to the fund-based model and that one fund-based measure (total fund balances/total fund revenues) also provides information incremental to the accrual indicator. These results are consistent with perceptions of regulators and others who expect accrual accounting to be a better measure of the economic costs of running a government than the traditional fund-based model.
Data Availability: Contact the authors.
Target Price Accuracy: International Evidence
Authors: Bilinski Pawel , Lyssimachou Danielle , Walker Martin 
Published: December 2012

ABSTRACT
Using an international sample of 16 countries, this paper examines if analyst- and country-specific characteristics explain the variation in target price (TP) accuracy. We find that significant variation in average TP accuracy across countries is due to differences in accounting disclosure quality, the origin of the legal system, cultural traits, and IFRS regulation. We also find that analysts exhibit differential and persistent ability to forecast target prices accurately, which confirms that some analysts have superior TP forecasting ability.
Data Availability: Data are available from public sources indicated in the text.
Primary Prevention of Macroangiopathy in Patients With Short-Duration Type 2 Diabetes by Intensified Multifactorial Intervention
Authors: Yang Yu , Yao Jun-jie , Du Jian-ling , Bai Ran , Sun Li-peng , Sun Guo-hua , Song Gui-rong , Cao Si-ming , Shi Chun-hong , Ba Ying , Xing Qian , Zhang Xue-yang 
Published: December 2012

OBJECTIVE
To explore whether intensified, multifactorial intervention could prevent macrovascular disease in patients with recently diagnosed type 2 diabetes.

RESEARCH DESIGN AND METHODS
A total of 150 type 2 diabetic patients, with disease duration of &lt;1 year and without clinical arteriosclerotic disease or subclinical atherosclerotic signs confirmed by ultrasonographic scanning of three conducting arteries, were randomized into an intensive intervention group and a conventional intervention group. They then received intensive, multifactorial intervention or conventional intervention over 7 years of follow-up. The patients’ common carotid intima-media thicknesses (CC-IMTs) were measured every year. The primary outcome was the time to the first occurrence of CC-IMTs ≥1.0 mm and/or development of atherosclerosis plaques in the carotid artery. The secondary outcome was clinical evidence of cardiovascular disease.

RESULTS
A total of 70 patients in the intensive group and 68 patients in the conventional group completed the 7-year follow-up. Subclinical macrovascular (primary) outcomes occurred in seven cases in the intensive group and 22 cases in the conventional group for a cumulative prevalence of 10.00 and 32.35%, respectively (P &lt; 0.05). No significant differences between the two groups were observed regarding the secondary outcome.

CONCLUSIONS
Primary prevention of macrovascular diseases can be achieved through intensified, multifactorial intervention in patients with short-duration type 2 diabetes. Type 2 diabetic patients should undergo intensive multifactorial interventions with individual targets for the prevention of macrovascular diseases.
The Midregional Fragment of Pro-A–Type Natriuretic Peptide, Blood Pressure, and Mortality in a Prospective Cohort Study of Patients With Type 2 Diabetes (ZODIAC-25)
Authors: van Hateren Kornelis J.J. , Landman Gijs W.D. , Kleefstra Nanne , Groenier Klaas H. , Struck Joachim , Navis Gerjan J. , Bakker Stephan J.L. , Houweling Sebastiaan T. , van der Meer Klaas , Bilo Henk J.G. 
Published: December 2012

OBJECTIVE
Evidence that midregional fragment of pro-A–type natriuretic peptide (MR-proANP) is a marker of mortality in patients with type 2 diabetes is limited. Therefore, we aimed to investigate the capabilities of MR-proANP in predicting mortality. We also investigated whether MR-proANP influences the relationship between blood pressure and mortality in old age.

RESEARCH DESIGN AND METHODS
In 1998, 1,143 primary care patients with type 2 diabetes participated in the ZODIAC study. Because blood was drawn for 867 patients (76%) and confounders were missing for 19 patients, the final study sample comprised 848 patients. After a follow-up time of 10 years, we used Cox proportional hazard models to evaluate the relationship between MR-proANP and (cardiovascular) mortality. Harrell C statistic was used to compare models with and without MR-proANP. The regression analyses were repeated without MR-proANP for patients aged older than 75 years.

RESULTS
Median MR-proANP in the total study sample was 75 pmol/L (interquartile range, 48–124 pmol/L). During follow-up, 354 (42%) out of 848 patients had died, of whom 152 (43%) deaths were attributable to cardiovascular factors. MR-proANP was independently associated with all-cause and cardiovascular mortality, irrespective of age. During old age, there was a significant inverse relationship between blood pressure and mortality. This relationship did not change after adjustment for MR-proANP.

CONCLUSIONS
MR-proANP is independently associated with mortality in patients with type 2 diabetes. MR-proANP did not influence the inverse relationship between blood pressure and mortality in elderly patients.