bluuebunny/crossref_metadata_2025_split huggingface dataset:
Submesoscale Water-Mass Spectra in the Sargasso Sea
Authors: Kunze E. , Klymak J. M. , Lien R.-C. , Ferrari R. , Lee C. M. , Sundermeyer M. A. , Goodman L. 
Published: March 2015

AbstractSubmesoscale stirring contributes to the cascade of tracer variance from large to small scales. Multiple nested surveys in the summer Sargasso Sea with tow-yo and autonomous platforms captured submesoscale water-mass variability in the seasonal pycnocline at 20–60-m depths. To filter out internal waves that dominate dynamic signals on these scales, spectra for salinity anomalies on isopycnals were formed. Salinity-gradient spectra are approximately flat with slopes of −0.2 ± 0.2 over horizontal wavelengths of 0.03–10 km. While the two to three realizations presented here might be biased, more representative measurements in the literature are consistent with a nearly flat submesoscale passive tracer gradient spectrum for horizontal wavelengths in excess of 1 km. A review of mechanisms that could be responsible for a flat passive tracer gradient spectrum rules out (i) quasigeostrophic eddy stirring, (ii) atmospheric forcing through a relict submesoscale winter mixed layer structure or nocturnal mixed layer deepening, (iii) a downscale vortical-mode cascade, and (iv) horizontal diffusion because of shear dispersion of diapycnal mixing. Internal-wave horizontal strain appears to be able to explain horizontal wavenumbers of 0.1–7 cycles per kilometer (cpkm) but not the highest resolved wavenumbers (7–30 cpkm). Submesoscale subduction cannot be ruled out at these depths, though previous observations observe a flat spectrum well below subduction depths, so this seems unlikely. Primitive equation numerical modeling suggests that nonquasigeostrophic subinertial horizontal stirring can produce a flat spectrum. The last need not be limited to mode-one interior or surface Rossby wavenumbers of quasigeostrophic theory but may have a broaderband spectrum extending to smaller horizontal scales associated with frontogenesis and frontal instabilities as well as internal waves.
High-Resolution Spectral Estimation of HF Radar Data for Current Measurement Applications
Authors: Wang Wei , Gill Eric 
Published: March 2015

AbstractThis paper presents a comparative study of high-resolution methods for high-frequency radar current mapping. A z-domain transformation and auxiliary z-domain manipulation of the autoregressive method is proposed for this comparison. A Weibull distribution test is recommended to justify the Rayleigh distribution of the sea clutter for quality control. Upon the power spectrum estimation, a conventional centroid method and a new symmetric-peak-sum method for the identification of current Doppler shift are proposed as another comparison. HF radar data were collected over the period from November 2012 to August 2013 at Placentia Bay, Newfoundland, Canada, and were compared with measurements from an acoustic Doppler current meter. This comparison is used to study the utility of high-resolution spectrum estimation and Bragg identification methods for surface current mapping. Results show promising use of these methods in different current scenarios and suggest combined applications to improve accuracy.
Intravenous iron in clinical concentrations does not impair haemoglobin measurement
Authors: O’Loughlin Edmond , Garnett Peter BJ , Falkner Nathalie M , Williams Robin 
Published: March 2015

Background Intravenous iron is commonly administered to anaemic patients to treat iron deficiency, but due to its ferric colouration, it may interfere with the spectrophotometric assessment of haemoglobin concentrations. This paper investigates the potential interference of three clinically used intravenous iron preparations on the measurement of haemoglobin. Methods Haemoglobin concentration was measured for neat and Hartmann’s solution-diluted iron polymaltose, carboxymaltose and sucrose solutions using bedside (Radiometer HemoCue®), point-of-care (Radiometer ABL800 Flex) and laboratory (Abbott CellDyne Sapphire™) devices. Haemoglobin concentration was then assessed with the same devices utilizing anaemic whole blood with the iron solutions added. Results Neat iron preparations registered clinically significant haemoglobin concentrations on bedside and laboratory measurements. When intravenous iron preparations were diluted to clinical concentrations, their effect on haemoglobin measurements, either in isolation or mixed with anaemic blood, was negligible. Conclusion Although neat preparations of intravenous iron do interfere with spectrophotometric analysis of haemoglobin, concentrations likely to be seen post iron infusion do not significantly interfere with haemoglobin measurement.
A cross-validation trial of an Internet-based prevention program for alcohol and cannabis: Preliminary results from a cluster randomised controlled trial
Authors: Champion Katrina E , Newton Nicola C , Stapinski Lexine , Slade Tim , Barrett Emma L , Teesson Maree 
Published: March 2015

Objective: Replication is an important step in evaluating evidence-based preventive interventions and is crucial for establishing the generalizability and wider impact of a program. Despite this, few replications have occurred in the prevention science field. This study aims to fill this gap by conducting a cross-validation trial of the Climate Schools: Alcohol and Cannabis course, an Internet-based prevention program, among a new cohort of Australian students. Method: A cluster randomized controlled trial was conducted among 1103 students ( Mage: 13.25 years) from 13 schools in Australia in 2012. Six schools received the Climate Schools course and 7 schools were randomized to a control group (health education as usual). All students completed a self-report survey at baseline and immediately post-intervention. Mixed-effects regressions were conducted for all outcome variables. Outcomes assessed included alcohol and cannabis use, knowledge and intentions to use these substances. Results: Compared to the control group, immediately post-intervention the intervention group reported significantly greater alcohol ( d = 0.67) and cannabis knowledge ( d = 0.72), were less likely to have consumed any alcohol (even a sip or taste) in the past 6 months (odds ratio = 0.69) and were less likely to intend on using alcohol in the future (odds ratio = 0.62). However, there were no effects for binge drinking, cannabis use or intentions to use cannabis. Conclusion: These preliminary results provide some support for the Internet-based Climate Schools: Alcohol and Cannabis course as a feasible way of delivering alcohol and cannabis prevention. Intervention effects for alcohol and cannabis knowledge were consistent with results from the original trial; however, analyses of longer-term follow-up data are needed to provide a clearer indication of the efficacy of the intervention, particularly in relation to behavioral changes.
Model-Based Concept of Operations Development Using Gaming Simulation
Authors: Korfiatis Peter , Cloutier Robert , Zigh Teresa 
Published: March 2015

Background. Extensive research exists in the application of gaming simulation to education, experimentation and policy. Systems engineers have begun to utilize gaming simulation during design. However, such applications have not extended to early design activities and have provided little evidence of value to systems engineering. Aim. The purpose of this research is to test the hypothesis that the use of gaming simulation will improve an artifact created early in the design process, the Concept of Operations (CONOPS). The aim of this article is to provide an update to work in progress towards testing this hypothesis. Method. A gaming simulation was developed that allows system stakeholders to interact in an immersive environment and develop CONOPS. Results. As the research has matured, informal free-form testing has been conducted. Debriefing has shown that players perceive value from this gaming simulation and yielded observations relative to fidelity, validity, and usability. Conclusion. The conclusion of this article points to preliminary acceptance of the use of gaming simulation towards CONOPS development. Future work will validate this assertion using quantitative data collected from controlled experiments.
Pregnancy outcomes in cystic fibrosis: a 10-year experience from a UK centre
Authors: Renton M , Priestley L , Bennett L , Mackillop L , Chapman SJ 
Published: March 2015

Background Cystic fibrosis manifests as a multisystem disease, despite this female fertility is relatively preserved with levels approaching that of the non-cystic fibrosis population. We reviewed pregnancies in cystic fibrosis patients over a 10-year period from a UK adult cystic fibrosis centre by considering maternal and fetal outcomes. Methods We conducted a retrospective case-note review of pregnancies during 2003–2013 using respiratory and obstetric records. Results We observed moderate falls in lung function immediately after delivery, which persisted at 12 months postpartum. We found that a decline in lung function at delivery was a marker for further decline in function during the subsequent postpartum period. We found baseline lung function was predictive of gestational age at delivery. We observed a high incidence of haemoptysis. Conclusion Consistent with current guidance we found pregnancy is feasible and well tolerated in the majority of patients with cystic fibrosis. There was a high incidence of haemoptysis, which warrants further study.
Endoscopic management of iatrogenic perforations during endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for colorectal polyps: a case series
Authors: Pissas Dimitrios , Ypsilantis Efthymios , Papagrigoriadis Savvas , Hayee Bu’Hussain , Haji Amyn 
Published: March 2015

Background: Iatrogenic perforation during therapeutic colonoscopy, reported in up to 1% of endoscopic mucosal resections (EMRs) and up to 14% of endoscopic submucosal dissections (ESDs), has conventionally been an indication for surgery. Aims: We present a case series of successful endoscopic management of iatrogenic colorectal perforation during EMR and ESD, demonstrating the feasibility and safety of the method. Methods: Retrospective analysis of a database of patients undergoing EMR and ESD for colorectal polyps in a tertiary referral centre in the United Kingdom. Results: Four cases of perforation were identified (two EMRs and two ESDs) in a series of 218 procedures (1.8%), all detected at the time of endoscopy and managed with endoscopic clips. Patients were observed in hospital and treated with antibiotics. Their median length of stay was 3 days (range 2–6 days), with no mortality or need for surgery. Conclusion: Surgery is no longer the first choice in the management of iatrogenic perforations during EMR and ESD for colorectal polyps; in selected patients with small perforations and minimal extraluminal contamination, conservative management with application of endoscopic clips, antibiotics and close patient monitoring constitute a safe and effective treatment option, avoiding the morbidity of major surgery.
Lower Extremity Kinematics During a Drop Jump in Individuals With Patellar Tendinopathy
Authors: Rosen Adam B. , Ko Jupil , Simpson Kathy J. , Kim Seock-Ho , Brown Cathleen N. 
Published: March 2015

Background: Patellar tendinopathy (PT) is a common degenerative condition in physically active populations. Knowledge regarding the biomechanics of landing in populations with symptomatic PT is limited, but altered mechanics may play a role in the development or perpetuation of PT. Purpose: To identify whether study participants with PT exhibited different landing kinematics compared with healthy controls. Study Design: Controlled laboratory study. Methods: Sixty recreationally active participants took part in this study; 30 had current signs and symptoms of PT, including self-reported pain within the patellar tendon during loading activities for at least 3 months and ≤80 on the Victorian Institute of Sport Assessment Scale–Patella (VISA-P). Thirty healthy participants with no history of PT or other knee joint pathology were matched by sex, age, height, and weight. Participants completed 5 trials of a 40-cm, 2-legged drop jump followed immediately by a 50% maximum vertical jump. Dependent variables of interest included hip, knee, and ankle joint angles at initial ground contact, peak angles, and maximum angular displacements during the landing phase in 3 planes. Independent-samples t tests ( P ≤ .05) were utilized to compare the joint angles and angular displacements between PT and control participants. Results: Individuals with PT displayed significantly decreased peak hip (PT, 59.2° ± 14.6°; control, 67.2° ± 13.9°; P = .03) and knee flexion angles (PT, 74.8° ± 13.2°; control, 82.5° ± 9.0°; P = .01) compared with control subjects. The PT group displayed decreased maximum angular displacement in the sagittal plane at the hip (PT, 49.3° ± 10.8°; control, 55.2° ± 11.4°; P = .04) and knee (PT, 71.6° ± 8.4°; control, 79.7° ± 8.3°; P < .001) compared with the control group. Conclusion: Participants with PT displayed decreased maximum flexion and angular displacement in the sagittal plane, at both the knee and the hip. The altered movement patterns in those with PT may be perpetuating symptoms associated with PT and could be due to the contributions of the rectus femoris during dynamic movement. Clinical Relevance: Based on kinematic alterations in symptomatic participants, rehabilitation efforts may benefit from focusing on both the knee and the hip to treat symptoms associated with PT.
Biosynthesis of gold nanoparticles assisted by the intracellular protein extract of Pycnoporus sanguineus and its catalysis in degradation of 4-nitroaniline
Authors: Shi Chaohong , Zhu Nengwu , Cao Yanlan , Wu Pingxiao 
Published: March 2015

Abstract
The development of green procedure for the synthesis of gold nanoparticles (AuNPs) has gained great interest in the field of nanotechnology. Biological synthetic routes are considered to be environmentally benign and cost-effective. In the present study, the feasibility of AuNPs’ synthesis via intracellular protein extract (IPE) of Pycnoporus sanguineus was explored. The characteristics of generated particles of formation, crystalline nature, and morphology and dimension were analyzed by UV-vis spectroscopy, X-ray diffraction (XRD) and transmission electron microscopy (TEM), respectively. UV-vis spectra exhibited strong absorption peaks in 520 to 560 nm, indicating the formation of AuNPs. XRD analysis revealed that the formed AuNPs were purely crystalline in nature. TEM observation showed that AuNPs with various shapes including spherical, pseudo-spherical, triangular, truncated triangular, pentagonal, and hexagonal, ranging from several to several hundred nanometers, were synthesized under different conditions. The average size of AuNPs decreased from 61.47 to 29.30 nm as the IPE addition increased from 10 to 80 mL. When the initial gold ion concentration changed from 0.5 to 2.0 mM, the average size rose from 25.88 to 51.99 nm. As in the case of solution pH, the average size was 84.29 nm with solution pH of 2.0, which diminished to 6.07 nm with solution pH of 12.0. Fourier transform infrared (FTIR) analysis implied that the functional groups including hydroxyl, amine, and carboxyl were involved in the reduction of gold ions and stabilization of AuNPs. The catalysis results showed that 0.019 mg of AuNPs with average size of 6.07 nm could catalyze the complete degradation of 12.5 μmol of 4-nitroaniline within 6 min and the degradation rate increased drastically with the addition of AuNPs. All the results suggested that the IPE of P. sanguineus could be potentially applied for the eco-friendly synthesis of AuNPs.
Defective structural RNA processing in relapsing-remitting multiple sclerosis
Authors: Spurlock Charles F , Tossberg John T , Guo Yan , Sriram Subramaniam , Crooke Philip S , Aune Thomas M 
Published: March 2015

Abstract
Background
Surveillance of integrity of the basic elements of the cell including DNA, RNA, and proteins is a critical element of cellular physiology. Mechanisms of surveillance of DNA and protein integrity are well understood. Surveillance of structural RNAs making up the vast majority of RNA in a cell is less well understood. Here, we sought to explore integrity of processing of structural RNAs in relapsing remitting multiple sclerosis (RRMS) and other inflammatory diseases.

Results
We employed mononuclear cells obtained from subjects with RRMS and cell lines. We used quantitative-PCR and whole genome RNA sequencing to define defects in structural RNA surveillance and siRNAs to deplete target proteins. We report profound defects in surveillance of structural RNAs in RRMS exemplified by elevated levels of poly(A) + Y1-RNA, poly(A) + 18S rRNA and 28S rRNAs, elevated levels of misprocessed 18S and 28S rRNAs and levels of the U-class of small nuclear RNAs. Multiple sclerosis is also associated with genome-wide defects in mRNA splicing. Ro60 and La proteins, which exist in ribonucleoprotein particles and play different roles in quality control of structural RNAs, are also deficient in RRMS. In cell lines, silencing of the genes encoding Ro60 and La proteins gives rise to these same defects in surveillance of structural RNAs.

Conclusions
Our results establish that profound defects in structural RNA surveillance exist in RRMS and establish a causal link between Ro60 and La proteins and integrity of structural RNAs.
Insulin initiation: bringing objectivity to choice
Authors: Kalra Sanjay , Gupta Yashdeep 
Published: March 2015

AbstractThe choice of initial insulin is often dictated by subjective criteria: the “severity” of diabetes, the ability of the person with diabetes to self inject, at specific times of the day, and the physician’s personal experience. No objective criteria have been evolved by any expert body so far to help guide clinicians make an appropriate, and accurate, choice of initiating insulin. Neither have large studies been able to shed light on the preferred type of insulin regime for a particular individual.This communication suggests various objective parameters which may be used to inform this decision.
Archaeological and archaeometric study of the glass finds from the ancient harbour of Classe (Ravenna- Italy): new evidence
Authors: Maltoni Sarah , Chinni Tania , Vandini Mariangela , Cirelli Enrico , Silvestri Alberta , Molin Gianmario 
Published: March 2015

Abstract

Introduction
The present study focuses on Late-Roman/Early Medieval glass found in the productive area within the ancient harbour of Classe near Ravenna, one of the most important trade centres between the 5th and 8th centuries AD of the Northern Adriatic area. Aims of the study were the identification of the main glass compositions and their contextualisation in Late-Antique groups; the identification of provenance of raw glass, and, consequently, of commercial routes; the extent, if any, of recycling glass cullet, as an alternative to the import of fresh raw glass; the identification of possible connections between archaeological typology and glass chemical composition.

Results
32 glassworking wastes and 25 drinking vessel fragments for a total amount of 57 fragments were devoted to chemical analysis in XRF and EPMA. All the analysed fragments are silica-soda lime glasses, produced with natron as a flux, and are compositionally similar to Late-Antique groups HIMT, Série 3.2 and Levantine1. Raw glass chunks, glassworking wastes and objects of comparable compositions are identified into HIMT and Série 3.2 groups, while the Levantine 1 group includes only objects and glassworking wastes. Systematic comparisons between Classe and Aquileia, the two most important Late-Antique archaeological sites of North-Eastern Italy, were also carried out, and the same compositional groups were identified, although Série 3.2 in the Classe assemblage is more represented. Sr and Nd isotopic analysis confirmed that the composition of the three glasses derive from coastal sands of the Syro-Palestinian and Egyptian shore, with a slight shift in comparison to the published data. Little evidence of recycling was identified in the assemblage.

Conclusions
In the 5th century, a secondary glass workshop devoted to the shaping of glass vessels starting from raw glass chunks and, possibly, glass cullet, was active in the area of the harbour.
Raw glass of HIMT and Série 3.2 was imported from the Levant and Egypt. Comparisons between Classe and Aquileia show that during the Late Antiquity these sites seem to be supplied of raw glass by the same trade routes. In addition, some connections between types and chemical compositions were highlighted.
Poisson noise removal from high-resolution STEM images based on periodic block matching
Authors: Mevenkamp Niklas , Binev Peter , Dahmen Wolfgang , Voyles Paul M , Yankovich Andrew B , Berkels Benjamin 
Published: March 2015

AbstractScanning transmission electron microscopy (STEM) provides sub-ångstrom, atomic resolution images of crystalline structures. However, in many applications, the ability to extract information such as atom positions, from such electron micrographs, is severely obstructed by low signal-to-noise ratios of the acquired images resulting from necessary limitations to the electron dose. We present a denoising strategy tailored to the special features of atomic-resolution electron micrographs of crystals limited by Poisson noise based on the block-matching and 3D-filtering (BM3D) algorithm by Dabov et al. We also present an economized block-matching strategy that exploits the periodic structure of the observed crystals. On simulated single-shot STEM images of inorganic materials, with incident electron doses below 4 C/cm 2, our new method achieves precisions of 7 to 15 pm and an increase in peak signal-to-noise ratio (PSNR) of 15 to 20 dB compared to noisy images and 2 to 4 dB compared to images denoised with the original BM3D.
Evaluation of repellents efficacy against Anopheles gambiae s.s.; an anthropophilic malaria vector
Authors: Katunzi Gerald , Munga Stephen , Nkwengulila Gamba , Kweka Eliningaya , Matias Jonathan R , Godfrey Gilbert M 
Published: March 2015

Reduction of human-vector contact is of epidemiological importance in malaria control. Repellents can be used to complement the existing intervention tools against malaria vectors. Thus, evaluation of efficacy of additional mosquito repellents and /or attractants is of great significance for personal protection tools against malaria vectors. This study evaluated the repellence efficacy of menthol-propylene-glycol-carbonate (MR08) and Lemon grass (LG) against Anopheles gambiae. Experiments were performed in a room which was 7.8 meters by 3.9 meters in dimension. Three experimental set ups were performed, i) comparison of 10 hours worn sock and unworn sock; ii) comparison of 10 hours worn sock treated with MR08 against worn sock alone, and iii) comparison of 10 hours worn sock treated with LG against worn sock alone. CDC miniature light traps were used to evaluate the recovery of released mosquitoes using both repellents and attractants. After initial trials, a concentration of 500 ppm was selected for all repellents. Among 1800 mosquitoes released into the experimental room, 1230 were recovered by CDC light traps while the remaining 570 were found within the experimental room. Among those collected by light traps, 1185 were collected by traps with worn sock alone. A worn sock treated with either MR08 or Lemon grass significantly repelled An.gambiae compared to worn sock alone. The findings of this study demonstrate that MR08 and lemon grass have inhibition efficiency against mosquito stings but further field evaluations are required for observed findings against wild populations of An.gambiae at lower Moshi using slow release method.