bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-trimester hemoglobin, haptoglobin genotype, and risk of gestational diabetes mellitus in a retrospective study among Chinese pregnant women
Authors: Li Yue , Wang Fang , Huang Xinmei , Zong Shuhang , Shen Yi , Guo Lina , Cai Qiongyi , Sun Tiange , Zhang Rui , Yu Zhiyan , Zhang Liwen , Zang Shufei , Liu Jun 
Published: July 2024

Abstract
Background
This study aimed to assess whether the Haptoglobin (Hp) genotype influences the relationship between hemoglobin (Hb) levels and the development of gestational diabetes mellitus (GDM). Additionally, it sought to evaluate the interaction and joint association of Hb levels and Hp genotype with GDM risk.

Methods
This retrospective study involved 358 women with GDM and 1324 women with normal glucose tolerance (NGT). Peripheral blood leukocytes were collected from 360 individuals at 14–16 weeks’ gestation for Hp genotyping. GDM was diagnosed between 24–28 weeks’ gestation. Interactive moderating effect, joint analysis, and mediation analysis were performed to evaluate the crosslink of Hb levels and Hp genotype with GDM risk.

Results
Women who developed GDM had significantly higher Hb levels throughout pregnancy compared to those with NGT. Increase first-trimester Hb concentration was associated with a progressive rise in GDM incidence, glucose levels, glycosylated hemoglobin levels, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) values, cesarean delivery rates, and composite neonatal outcomes. Spline regression showed a significant linear association of GDM incidence with continuous first-trimester Hb level when the latter exceeded 122 g/L. Increased first-trimester Hb concentration was an independent risk factor for GDM development after adjusting for potential confounding factors in both the overall population and a matched case-control group. The Hp2–2 genotype was more prevalent among pregnant women with GDM when first-trimester Hb exceeded 122 g/L. Significant multiplicative and additive interactions were identified between Hb levels and Hp genotype for GDM risk, adjusted for age and pre-pregnancy BMI. The odds ratio (OR) for GDM development increased incrementally when stratified by Hb levels and Hp genotype. Moreover, first-trimester Hb level partially mediated the association between Hp genotype and GDM risk.

Conclusion
Increased first-trimester Hb levels were closely associated with the development of GDM and adverse pregnancy outcomes, with this association moderated by the Hp2–2 genotype.
Development of graphitic carbon nitride quantum dots-based oxygen self-sufficient platforms for enhanced corneal crosslinking
Authors: Yang Mei , Chen Tingting , Chen Xin , Pan Hongxian , Zhao Guoli , Chen Zhongxing , Zhao Nan , Ye Qianfang , Chen Ming , Zhang Shenrong , Gao Rongrong , Meek Keith M. , Hayes Sally , Ma Xiaowei , Li Xin , Wu Yue , Zhang Yiming , Kong Na , Tao Wei , Zhou Xingtao , Huang Jinhai 
Published: July 2024

AbstractKeratoconus, a disorder characterized by corneal thinning and weakening, results in vision loss. Corneal crosslinking (CXL) can halt the progression of keratoconus. The development of accelerated corneal crosslinking (A-CXL) protocols to shorten the treatment time has been hampered by the rapid depletion of stromal oxygen when higher UVA intensities are used, resulting in a reduced cross-linking effect. It is therefore imperative to develop better methods to increase the oxygen concentration within the corneal stroma during the A-CXL process. Photocatalytic oxygen-generating nanomaterials are promising candidates to solve the hypoxia problem during A-CXL. Biocompatible graphitic carbon nitride (g-C3N4) quantum dots (QDs)-based oxygen self-sufficient platforms including g-C3N4QDs and riboflavin/g-C3N4QDs composites (RF@g-C3N4QDs) have been developed in this study. Both display excellent photocatalytic oxygen generation ability, high reactive oxygen species (ROS) yield, and excellent biosafety. More importantly, the A-CXL effect of the g-C3N4QDs or RF@g-C3N4QDs composite on male New Zealand white rabbits is better than that of the riboflavin 5’-phosphate sodium (RF) A-CXL protocol under the same conditions, indicating excellent strengthening of the cornea after A-CXL treatments. These lead us to suggest the potential application of g-C3N4QDs in A-CXL for corneal ectasias and other corneal diseases.
Giant nonlinear Hall and wireless rectification effects at room temperature in the elemental semiconductor tellurium
Authors: Cheng Bin , Gao Yang , Zheng Zhi , Chen Shuhang , Liu Zheng , Zhang Ling , Zhu Qi , Li Hui , Li Lin , Zeng Changgan 
Published: July 2024

AbstractThe second-order nonlinear Hall effect (NLHE) in non-centrosymmetric materials has recently drawn intense interest, since its inherent rectification could enable various device applications such as energy harvesting and wireless charging. However, previously reported NLHE systems normally suffer from relatively small Hall voltage outputs and/or low working temperatures. In this study, we report the observation of a pronounced NLHE in tellurium (Te) thin flakes at room temperature. Benefiting from the semiconductor nature of Te, the obtained nonlinear response can be readily enhanced through electrostatic gating, leading to a second-harmonic output at 300 K up to 2.8 mV. By utilizing such a giant NLHE, we further demonstrate the potential of Te as a wireless Hall rectifier within the radiofrequency range, which is manifested by the remarkable and tunable rectification effect also at room temperature. Extrinsic scattering is then revealed to be the dominant mechanism for the NLHE in Te, with symmetry breaking on the surface playing a key role. As a simple elemental semiconductor, Te provides an appealing platform to advance our understanding of nonlinear transport in solids and to develop NLHE-based electronic devices.
Microscale geometrical modulation of PIEZO1 mediated mechanosensing through cytoskeletal redistribution
Authors: Wang Haoqing Jerry , Wang Yao , Mirjavadi Seyed Sajad , Andersen Tomas , Moldovan Laura , Vatankhah Parham , Russell Blake , Jin Jasmine , Zhou Zijing , Li Qing , Cox Charles D. , Su Qian Peter , Ju Lining Arnold 
Published: July 2024

AbstractThe microgeometry of the cellular microenvironment profoundly impacts cellular behaviors, yet the link between it and the ubiquitously expressed mechanosensitive ion channel PIEZO1 remains unclear. Herein, we describe a fluorescent micropipette aspiration assay that allows for simultaneous visualization of intracellular calcium dynamics and cytoskeletal architecture in real-time, under varied micropipette geometries. By integrating elastic shell finite element analysis with fluorescent lifetime imaging microscopy and employing PIEZO1-specific transgenic red blood cells and HEK cell lines, we demonstrate a direct correlation between the microscale geometry of aspiration and PIEZO1-mediated calcium signaling. We reveal that increased micropipette tip angles and physical constrictions lead to a significant reorganization of F-actin, accumulation at the aspirated cell neck, and subsequently amplify the tension stress at the dome of the cell to induce more PIEZO1’s activity. Disruption of the F-actin network or inhibition of its mobility leads to a notable decline in PIEZO1 mediated calcium influx, underscoring its critical role in cellular mechanosensing amidst geometrical constraints.
A unified European hydrogen infrastructure planning to support the rapid scale-up of hydrogen production
Authors: Kountouris Ioannis , Bramstoft Rasmus , Madsen Theis , Gea-Bermúdez Juan , Münster Marie , Keles Dogan 
Published: July 2024

AbstractHydrogen will become a key player in transitioning toward a net-zero energy system. However, a clear pathway toward a unified European hydrogen infrastructure to support the rapid scale-up of hydrogen production is still under discussion. This study explores plausible pathways using a fully sector-coupled energy system model. Here, we assess the emergence of hydrogen infrastructure build-outs connecting neighboring European nations through hydrogen import and domestic production centers with Western and Central European demands via four distinct hydrogen corridors. We identify a potential lock-in effect of blue hydrogen in the medium term, highlighting the risk of long-term dependence on methane. In contrast, we show that a self-sufficient Europe relying on domestic green hydrogen by 2050 would increase yearly expenses by around 3% and require 518 gigawatts of electrolysis capacity. This study emphasizes the importance of rapidly scaling up electrolysis capacity, building hydrogen networks and storage facilities, deploying renewable electricity generation, and ensuring coherent coordination across European nations.
Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson’s disease
Authors: Alushaj Erind , Hemachandra Dimuthu , Ganjavi Hooman , Seergobin Ken N. , Sharma Manas , Kashgari Alia , Barr Jennifer , Reisman William , Khan Ali R. , MacDonald Penny A. 
Published: July 2024

AbstractIdiopathic rapid eye movement sleep behaviour disorder (iRBD)—a Parkinson’s disease (PD) prodrome—might exhibit neural changes similar to those in PD. Substantia nigra pars compacta (SNc) degeneration underlies motor symptoms of PD. In iRBD and early PD (ePD), we measured diffusion MRI (dMRI) in the caudal motor SNc, which overlaps the nigrosome-1—the earliest-degenerating dopaminergic neurons in PD—and in the striatum. Nineteen iRBD, 26 ePD (1.7 ± 0.03 years), and 46 age-matched healthy controls (HCs) were scanned at Western University, and 47 iRBD, 115 ePD (0.9 ± 0.01 years), and 56 HCs were scanned through the Parkinson’s Progression Markers Initiative, using 3T MRI. We segmented the SNc and striatum into subregions using automated probabilistic tractography to the cortex. We measured mean diffusivity (MD) and fractional anisotropy (FA) along white-matter bundles and subregional surfaces. We performed group-level and classification analyses. Increased caudal motor SNc surface MD was the only iRBD-HCs and ePD-HCs difference replicating across datasets (padj < 0.05). No iRBD-ePD differences emerged. Caudal motor SNc surface MD classified patient groups from HCs at the single-subject level with good-to-excellent balanced accuracy in an independent sample (0.91 iRBD and 0.86 iRBD and ePD combined), compared to fair performance for total SNc surface MD (0.72 iRBD and ePD). Caudal motor SNc surface MD correlated significantly with MDS-UPDRS-III scores in ePD patients. Using dMRI and automated segmentation, we detected changes suggesting altered microstructural integrity in iRBD and ePD in the nigrostriatal subregion known to degenerate first in PD. Surface MD of the caudal motor SNc presents a potential measure for inclusion in neuroimaging biomarkers of iRBD and PD.
Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers
Authors: Schumacher Julia , Ray Nicola , Teipel Stefan , Storch Alexander 
Published: July 2024

AbstractIn Parkinson’s disease (PD), GBA1- and LRRK2-mutations are associated with different clinical phenotypes which might be related to differential involvement of the cholinergic system. We investigated cholinergic integrity in 149 asymptomatic GBA1 and 169 asymptomatic LRRK2 mutation carriers, 112 LRRK2 and 60 GBA1 carriers with PD, 492 idiopathic PD, and 180 controls from the PPMI cohort. Basal forebrain volumes were extracted and white matter pathways from nucleus basalis of Meynert (NBM) to cortex and from pedunculopontine nucleus (PPN) to thalamus were assessed with a free water-corrected DTI model. Bayesian ANCOVAs were conducted for group comparisons and Bayesian linear mixed models to assess associations with cognitive decline. Basal forebrain volumes were increased in asymptomatic GBA1 (Bayes Factor against the null hypothesis (BF10) = 75.2) and asymptomatic LRRK2 (BF10 = 57.0) compared to controls. Basal forebrain volumes were increased in LRRK2- compared to GBA1-PD (BF10 = 14.5) and idiopathic PD (BF10 = 3.6*107), with no difference between idiopathic PD and PD-GBA1 (BF10 = 0.25). Mean diffusivity along the medial NBM pathway was decreased in asymptomatic GBA1 compared to controls (BF10 = 30.3). Over 5 years, idiopathic PD and PD-GBA1 declined across all cognitive domains whereas PD-LRRK2 patients only declined in processing speed. We found an interaction between basal forebrain volume and time in predicting multiple cognitive domains in idiopathic PD and PD-GBA1, but not in PD-LRRK2. While LRRK2 and GBA1 mutations are both associated with increased basal forebrain volume at asymptomatic stages, this increase persists at the symptomatic PD stage only in LRRK2 and might be related to slower cognitive decline in these patients.
Diastereodivergent nucleophile–nucleophile alkene chlorofluorination
Authors: Doobary Sayad , Lacey Andrew J. D. , Sweeting Stephen G. , Coppock Sarah B. , Caldora Henry P. , Poole Darren L. , Lennox Alastair J. J. 
Published: July 2024

AbstractThe selective hetero-dihalogenation of alkenes provides useful building blocks for a broad range of chemical applications. Unlike homo-dihalogenation, selective hetero-dihalogenation reactions, especially fluorohalogenation, are underdeveloped. Current approaches combine an electrophilic halogen source with a nucleophilic halogen source, which necessarily leads to anti-addition, and regioselectivity has only been achieved using highly activated alkenes. Here we describe an alternative, nucleophile–nucleophile approach that adds chloride and fluoride ions over unactivated alkenes in a highly regio-, chemo- and diastereoselective manner. A curious switch in the reaction mechanism was discovered, which triggers a complete reversal of the diastereoselectivity to promote either anti- or syn-addition. The conditions are demonstrated on an array of pharmaceutically relevant compounds, and detailed mechanistic studies reveal the selectivity and the switch between the syn- and anti-diastereomers are based on different active iodanes and which of the two halides adds first.
Climate-driven deoxygenation of northern lakes
Authors: Jansen Joachim , Simpson Gavin L. , Weyhenmeyer Gesa A. , Härkönen Laura H. , Paterson Andrew M. , del Giorgio Paul A. , Prairie Yves T. 
Published: July 2024

AbstractOxygen depletion constitutes a major threat to lake ecosystems and the services they provide. Most of the world’s lakes are located >45° N, where accelerated climate warming and elevated carbon loads might severely increase the risk of hypoxia, but this has not been systematically examined. Here analysis of 2.6 million water quality observations from 8,288 lakes shows that between 1960 and 2022, most northern lakes experienced rapid deoxygenation strongly linked to climate-driven prolongation of summer stratification. Oxygen levels deteriorated most in small lakes (<10 ha) owing to their greater volumetric oxygen demand and surface warming rates, while the largest lakes gained oxygen under minimal stratification changes and improved aeration at spring overturns. Seasonal oxygen consumption rates declined, despite widespread browning. Proliferating anoxia enhanced seasonal internal loading of C, P and N but depleted P long-term, indicating that deoxygenation can exhaust redox-sensitive fractions of sediment nutrient reservoirs.
Archaeological evidence of an ethnographically documented Australian Aboriginal ritual dated to the last ice age
Authors: David Bruno , Mullett Russell , Wright Nathan , Stephenson Birgitta , Ash Jeremy , Fresløv Joanna ,   GunaiKurnai Land and Waters Aboriginal Corporation, Delannoy Jean-Jacques , McDowell Matthew C. , Mialanes Jerome , Petchey Fiona , Arnold Lee J. , Rogers Ashleigh J. , Crouch Joe , Green Helen , Urwin Chris , Matheson Carney D. 
Published: July 2024

AbstractIn societies without writing, ethnographically known rituals have rarely been tracked back archaeologically more than a few hundred years. At the invitation of GunaiKurnai Aboriginal Elders, we undertook archaeological excavations at Cloggs Cave in the foothills of the Australian Alps. In GunaiKurnai Country, caves were not used as residential places during the early colonial period (mid-nineteenth century CE), but as secluded retreats for the performance of rituals by Aboriginal medicine men and women known as ‘mulla-mullung’, as documented by ethnographers. Here we report the discovery of buried 11,000- and 12,000-year-old miniature fireplaces with protruding trimmed wooden artefacts made of Casuarina wood smeared with animal or human fat, matching the configuration and contents of GunaiKurnai ritual installations described in nineteenth-century ethnography. These findings represent 500 generations of cultural transmission of an ethnographically documented ritual practice that dates back to the end of the last ice age and that contains Australia’s oldest known wooden artefacts.
Non-Abelian braiding of Fibonacci anyons with a superconducting processor
Authors: Xu Shibo , Sun Zheng-Zhi , Wang Ke , Li Hekang , Zhu Zitian , Dong Hang , Deng Jinfeng , Zhang Xu , Chen Jiachen , Wu Yaozu , Zhang Chuanyu , Jin Feitong , Zhu Xuhao , Gao Yu , Zhang Aosai , Wang Ning , Zou Yiren , Tan Ziqi , Shen Fanhao , Zhong Jiarun , Bao Zehang , Li Weikang , Jiang Wenjie , Yu Li-Wei , Song Zixuan , Zhang Pengfei , Xiang Liang , Guo Qiujiang , Wang Zhen , Song Chao , Wang H. , Deng Dong-Ling 
Published: July 2024

AbstractQuantum many-body systems with a non-Abelian topological order can host anyonic quasiparticles. It has been proposed that anyons could be used to encode and manipulate information in a topologically protected manner that is immune to local noise, with quantum gates performed by braiding and fusing anyons. Unfortunately, realizing non-Abelian topologically ordered states is challenging, and it was not until recently that the signatures of non-Abelian statistics were observed through digital quantum simulation approaches. However, not all forms of topological order can be used to realize universal quantum computation. Here we use a superconducting quantum processor to simulate non-Abelian topologically ordered states of the Fibonacci string-net model and demonstrate braidings of Fibonacci anyons featuring universal computational power. We demonstrate the non-trivial topological nature of the quantum states by measuring the topological entanglement entropy. In addition, we create two pairs of Fibonacci anyons and demonstrate their fusion rule and non-Abelian braiding statistics by applying unitary gates on the underlying physical qubits. Our results establish a digital approach to explore non-Abelian topological states and their associated braiding statistics with current noisy intermediate-scale quantum processors.
Empowering deep neural quantum states through efficient optimization
Authors: Chen Ao , Heyl Markus 
Published: July 2024

AbstractComputing the ground state of interacting quantum matter is a long-standing challenge, especially for complex two-dimensional systems. Recent developments have highlighted the potential of neural quantum states to solve the quantum many-body problem by encoding the many-body wavefunction into artificial neural networks. However, this method has faced the critical limitation that existing optimization algorithms are not suitable for training modern large-scale deep network architectures. Here, we introduce a minimum-step stochastic-reconfiguration optimization algorithm, which allows us to train deep neural quantum states with up to 106 parameters. We demonstrate our method for paradigmatic frustrated spin-1/2 models on square and triangular lattices, for which our trained deep networks approach machine precision and yield improved variational energies compared to existing results. Equipped with our optimization algorithm, we find numerical evidence for gapless quantum-spin-liquid phases in the considered models, an open question to date. We present a method that captures the emergent complexity in quantum many-body problems through the expressive power of large-scale artificial neural networks.
Prevalence and 20-year trends in meditation, yoga, guided imagery and progressive relaxation use among US adults from 2002 to 2022
Authors: Davies Jonathan N. , Faschinger Anna , Galante Julieta , Van Dam Nicholas T. 
Published: July 2024

AbstractMeditation, yoga, guided imagery, and progressive relaxation are promoted as complementary approaches for health and wellbeing in the United States, but their uptake by different sociodemographic groups is unclear. This study assessed the prevalence and 20 year trends in the use of these practices in US adults between 2002–2022. We examined practice use and associations with sociodemographic and health factors in a population-weighted analysis of n = 134,959 participants across 5 cycles of the National Health Interview Survey. The overall use of meditation (18.3%, 60.53 million), yoga (16.8%, 55.78 million) and guided imagery/progressive relaxation (6.7%, 22.22 million) increased significantly from 2002 to 2022. Growth was consistent across most sociodemographic and health strata, however users of ‘Other’ race (comprising 54% Indigenous Americans, Odds Ratios; ORs = 1.28–1.70) and users with moderate (ORs = 1.19–1.29) psychological distress were overrepresented across all practices, and those with severe psychological distress were overrepresented in meditation (OR = 1.33) and guided imagery/progressive relaxation (OR = 1.42). Meditation use has accelerated over time for 65 + year olds (OR = 4.22), people not accessing mental health care (OR = 1.39), and less educated (OR = 4.02) groups, potentially reflecting unmet health needs. Health professionals should consider the extensive use of complementary practices in service and treatment planning and consider their risks and benefits.
Compounded wind gusts and maximum temperature via semiparametric copula in the risk assessments of power blackouts and air conditioning demands for major cities in Canada
Authors: Latif Shahid , Ouarda Taha B. M. J. 
Published: July 2024

AbstractA semiparametric copula joint framework was proposed to model wind gust speed (WGS) and maximum temperature (MT) in Canada, using Gaussian kernel density estimation (GKDE) with parametric copulas. Their joint probability estimates allow for a better understanding of the risk of power blackouts and the demand for air conditioning in the community. The bivariate framework used two extreme sample groups to define extreme pairs at different time lags, i.e., 0 to ± 3 days, annual maximum WGS (AMWGS) and corresponding MT and annual highest MT (AHMT) and corresponding WGS. A thorough model performance comparison indicated that GKDE outperformed the parametric models in defining the marginal distribution of selected univariate series. Significant positive correlations were observed among extreme pairs, except for Calgary and Halifax stations, with inconsistent correlation variations based on selected cities and lag time. Various parametric 2-D copulas were selected to model the dependence structure of bivariate pairs at different time lags for selected stations. AMWGS or AHMT events, when considered independently, would be stressful for all stations due to high estimated quantiles with low univariate RPs. The bivariate events exhibited lower AND-joint RPs with moderate to high design quantiles, indicating a higher risk of power blackouts and heightened air-conditioning demands, which varied inconsistently with time lags across the station. The bivariate AMWGS and corresponding MT events would be stressful in Regina, Quebec City, Ottawa, and Edmonton, while AHMT and corresponding WGS events in Toronto, Regina, and Montreal. Conversely, Vancouver poses a lower risk of joint action of pairs AHMT and corresponding WGS events. These hazard statistics can help in better planning for community well-being during extreme weather.