bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic PFOS exposures induce life stage–specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring
Authors: Chen Jiangfei , Das Siba R. , La Du Jane , Corvi Margaret M. , Bai Chenglian , Chen Yuanhong , Liu Xiaojuan , Zhu Guonian , Tanguay Robert L. , Dong Qiaoxiang , Huang Changjiang 
Published: October 2012

Abstract
Perfluorooctane sulfonic acid (PFOS) is an organic contaminant that is ubiquitous in the environment. Few studies have assessed the behavioral effects of chronic PFOS exposure in aquatic organisms. The present study defined the behavioral effects of varying life span chronic exposures to PFOS in zebrafish. Specifically, zebrafish were exposed to control or 0.5 µM PFOS during 1 to 20, 21 to 120, or 1 to 120 d postfertilization (dpf). Exposure to PFOS impaired the adult zebrafish behavior mode under the tapping stimulus. The movement speed of male and female fish exposed for 1 to 120 dpf was significantly increased compared with control before and after tapping, whereas in the groups exposed for 1 to 20 and 21 to 120 dpf, only the males exhibited elevated swim speed before tapping. Residues of PFOS in F1 embryos derived from parental exposure for 1 to 120 and 21 to 120 dpf were significantly higher than control, and F1 embryos in these two groups also showed high malformation and mortality. The F1 larvae of parental fish exposed to PFOS for 1 to 20 or 21 to 120 dpf exhibited a higher swimming speed than control larvae in a light-to-dark behavior assessment test. The F1 larvae derived from parental fish exposed to PFOS for 1 to 120 dpf showed a significantly lower speed in the light period and a higher speed in the dark period compared with controls. Although there was little PFOS residue in embryos derived from the 1- to 20-dpf parental PFOS-exposed group, the adverse behavioral effects on both adult and F1 larvae indicate that exposure during the first 21 dpf induces long-term neurobehaviorial toxicity. The authors' findings demonstrate that chronic PFOS exposure during different life stages adversely affects adult behavior and F1 offspring morphology, behavior, and survival. Environ. Toxicol. Chem. 2013;32:201–206. © 2012 SETAC
An analysis of channel access delay in synchronized MAC protocol for cognitive radio networks
Authors: Joshi Gyanendra Prasad , Nam Seung Yeob , Kim Sung Won 
Published: October 2012

ABSTRACTThe spectrum scarcity issue due to a fixed radio spectrum allocation system has become an obstacle to future wireless communications. In cognitive radio, the idea of an open spectrum was devised, which allows unlicensed users to utilise these underutilised licensed spectrum bands opportunistically. Several synchronisation‐based, Medium Access Control protocols for cognitive radio networks have been reported. This study examines how these protocols suffer from the common control channel bottleneck problem in a dense network. The analysis shows that control messages exchanging in a fixed channel negotiation window in the control channel is not efficient in dense cognitive radio networks. This increases the channel access delay and limits the network performance. This study develops an analytical model to calculate the expected channel access delay and analyse the impact of the number of nodes on the channel access. The analysis is verified with simulations. Copyright © 2012 John Wiley & Sons, Ltd.
On the performance of amplify‐and‐forward protocol with generalised order selection combining
Authors: Chu Shao‐I , Lee Hung‐Peng , Chang Hsin‐Chiu , Lin Wei‐Cheng 
Published: October 2012

ABSTRACTThis paper investigates the performance of amplify‐and‐forward protocol with selection combining of , and best relays. The closed‐form expressions for the symbol error rate, outage probability and channel capacity are derived. Analysis reveals that the diversity‐multiplexing trade‐off is (R − i1 + 2)[1 − r(1 + K)], where r is the multiplexing gain and R is the total number of relays. Investigation also shows that the fixed‐gain relaying provides the same diversity gain with the variable‐gain relaying. Simulation and numerical results substantiate the tightness of derived expressions and the accuracy of our theoretical analysis. Copyright © 2012 John Wiley & Sons, Ltd.
SOCIAL CONTAGION OF MENTAL HEALTH: EVIDENCE FROM COLLEGE ROOMMATES
Authors: Eisenberg Daniel , Golberstein Ezra , Whitlock Janis L. , Downs Marilyn F. 
Published: October 2012

ABSTRACTFrom a policy standpoint, the spread of health conditions in social networks is important to quantify, because it implies externalities and possible market failures in the consumption of health interventions. Recent studies conclude that happiness and depression may be highly contagious across social ties. The results may be biased, however, because of selection and common shocks. We provide unbiased estimates by using exogenous variation from college roommate assignments. Our findings are consistent with no significant overall contagion of mental health and no more than small contagion effects for specific mental health measures, with no evidence for happiness contagion and modest evidence for anxiety and depression contagion. The weakness of the contagion effects cannot be explained by avoidance of roommates with poor mental health or by generally low social contact among roommates. We also find that similarity of baseline mental health predicts the closeness of roommate relationships, which highlights the potential for selection biases in studies of peer effects that do not have a clearly exogenous source of variation. Overall, our results suggest that mental health contagion is lower, or at least more context specific, than implied by the recent studies in the medical literature. Copyright © 2012 John Wiley & Sons, Ltd.
THE EFFECT OF HOSPITAL–PHYSICIAN INTEGRATION ON HEALTH INFORMATION TECHNOLOGY ADOPTION
Authors: Lammers Eric 
Published: October 2012

ABSTRACTThe US federal government has recently made a substantial investment to enhance the US health information technology (IT) infrastructure. Previous literature on the impact of IT on firm performance across multiple industries has emphasized the importance of a process of co‐invention whereby organizations develop complementary practices to achieve greater benefit from their IT investments. In health care, employment of physicians by hospitals can confer greater administrative control to hospitals over physicians' actions and resources and thus enable the implementation of new technology and initiatives aimed at maximizing benefit from use of the technology. In this study, I tested for the relationship between hospital employment of physicians and hospitals' propensity to use health IT. I used state laws that prohibit hospital employment of physicians as an instrument to account for the endogenous relationship with hospital IT use. Hospital employment of physicians is associated with significant increases in the probability of hospital health IT use. Therefore, subsidization of health IT among hospitals not employing physicians may be less efficient. Furthermore, state laws prohibiting hospitals from employing physicians may inhibit adoption of health IT, thus working against policy initiatives aimed at promoting use of the technology. Copyright © 2012 John Wiley & Sons, Ltd.
CD34+/CD38− acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells
Authors: Nishioka Chie , Ikezoe Takayuki , Furihata Mutsuo , Yang Jing , Serada Satoshi , Naka Tetsuji , Nobumoto Atsuya , Kataoka Sayo , Tsuda Masayuki , Udaka Keiko , Yokoyama Akihito 
Published: October 2012

AbstractTo identify molecular targets in leukemia stem cells (LSCs), this study compared the protein expression profile of freshly isolated CD34+/CD38− cells with that of CD34+/CD38+ counterparts from individuals with acute myelogenous leukemia (n = 2, AML) using isobaric tags for relative and absolute quantitation (iTRAQ). A total of 98 proteins were overexpressed, while six proteins were underexpressed in CD34+/CD38− AML cells compared with their CD34+/CD38+ counterparts. Proteins overexpressed in CD34+/CD38− AML cells included a number of proteins involved in DNA repair, cell cycle arrest, gland differentiation, antiapoptosis, adhesion, and drug resistance. Aberrant expression of CD82, a family of adhesion molecules, in CD34+/CD38− AML cells was noted in additional clinical samples (n = 12) by flow cytometry. Importantly, down‐regulation of CD82 in CD34+/CD38− AML cells by a short hairpin RNA (shRNA) inhibited adhesion to fibronectin via up‐regulation of matrix metalloproteinases 9 (MMP9) and colony forming ability of these cells as assessed by transwell assay, real‐time RT‐PCR, and colony forming assay, respectively. Moreover, we found that down‐regulation of CD82 in CD34+/CD38− AML cells by an shRNA significantly impaired engraftment of these cells in severely immunocompromised mice. Taken together, aberrant expression of CD82 might play a role in adhesion of LSCs to bone marrow microenvironment and survival of LSCs. CD82 could be an attractive molecular target to eradicate LSCs.
uPA and MMP‐2 were involved in self‐assembled network formation in a two dimensional co‐culture model of bone marrow stromal cells and endothelial cells
Authors: Li Haiyan , Daculsi Richard , Bareille Reine , Bourget Chantal , Amedee Joëlle 
Published: October 2012

AbstractTwo dimensional (2D) co‐cultures of human bone marrow stromal cells (HBMSCs) and human umbilical vein endothelial cells (HUVECs) stimulate osteoblastic differentiation of HBMSCs, induce the formation of self‐assembled network and cell interactions between the two cell types involving many vascular molecules. Because of their strong activities on angiogenesis and tissue remodeling, urokinase plasminogen activator (uPA), plasminogen activator inhibitor‐1 (PAI‐1), matrix metalloproteinase‐2 (MMP‐2) as well tissue inhibitors of matrix metalloproteinase‐2 (TIMP‐2) were investigated in this 2D co‐culture model. We found that the expression of uPA, MMP‐2 in the co‐cultured cells was significantly higher than those in mono‐cultured cells. In opposite, PAI‐1, expressed only by HUVECs is not regulated in the co‐culture. Inhibition assays confirm that uPA played a critical role in the formation of self‐assembled network as neutralization of uPA disturbed this network. In the same context, inhibition of MMP‐2 prevented the formation of self‐assembled network, while the inhibition of uPA abolished the over expression and the activity of MMP‐2. This upregulation could initiate the uPA expression and proteolysis processes through the MMP‐2 activity, and may contribute to endothelial cell migration and the formation of this self‐assembled network observed in these 2D co‐cultured cells. J. Cell. Biochem. 114: 650–657, 2013. © 2012 Wiley Periodicals, Inc.
Novel technique for MR elastography of the prostate using a modified standard endorectal coil as actuator
Authors: Thörmer Gregor , Reiss‐Zimmermann Martin , Otto Josephin , Hoffmann Karl‐Titus , Moche Michael , Garnov Nikita , Kahn Thomas , Busse Harald 
Published: October 2012

AbstractPurpose:To present a novel method for MR elastography (MRE) of the prostate at 3 Tesla using a modified endorectal imaging coil.Materials and Methods:A commercial endorectal coil was modified to dynamically generate mechanical stress (contraction and dilation) in a prostate phantom with embedded phantom “lesions” (6 mm diameter) and in a porcine model. Resulting tissue displacements were measured with a motion‐sensitive EPI sequence at actuation frequencies of 50–200 Hz. Maps of shear modulus G were calculated from the measured phase‐difference shear‐wave patterns.Results:In the G maps of the phantom, “lesions” were easily discernible against the background. The average G values of regions of interest placed in the “lesion” (8.2 ± 1.9 kPa) were much higher than those in the background (3.6 ± 1.4 kPa) but systematically lower than values reported by the vendor (13.0 ± 1.0 and 6.7 ± 0.7 kPa, respectively). In the porcine model, shear waves could be generated and measured shear moduli were substantially different for muscle (7.1 ± 2.0 kPa), prostate (3.0 ± 1.4 kPa), and bulbourethral gland (5.6 ± 1.9 kPa).Conclusion:An endorectal MRE concept is technically feasible. The presented technique will allow for simultaneous MRE and MRI acquisitions using a commercial base device with minor, MR‐conditional modifications. The diagnostic value needs to be determined in further trials. J. Magn. Reson. Imaging 2013;37:1480–1485. © 2012 Wiley Periodicals, Inc.
Delineation of motor and somatosensory thalamic subregions utilizing probabilistic diffusion tractography and electrophysiology
Authors: Sudhyadhom Atchar , McGregor Keith , Okun Michael S. , Foote Kelly D. , Trinastic Jonathan , Crosson Bruce , Bova Frank J. 
Published: October 2012

AbstractPurpose:To employ and compare probabilistic diffusion tractography (PDT) for the explicit localization of connections from the thalamus to somatosensory cortex (S1) and primary motor cortex (M1) / supplementary motor area (SMA) with microelectrode electrophysiology in patients undergoing deep brain stimulation (DBS) surgery.Materials and Methods:These tractography‐derived connections were used to categorize voxels in the thalamus as corresponding to sensory or motor physiology. A novel model (referred to in this work as the “mixture” model) to delineate PDT‐based thalamic functional subregions by thresholding fiber intensities, ie, connectivity‐defined regions (CDR), was devised. Regions created using this classification method were compared with the most commonly used model (referred to in this work as the “separation” or “winner takes all” model) for defining CDRs.Results:Electrophysiology data corresponded better for S1 CDRs created using the mixture model for both sensory and motor cells. Separation model CDRs showed poor correspondence against electrophysiology, with few sensory cells corresponding to the S1 separation model CDR.Conclusion:Mixture model‐based CDRs may offer a significant improvement in delineation of functional subregions of subcortical structures. J. Magn. Reson. Imaging 2013;37:600–609. © 2012 Wiley Periodicals, Inc.
Output capabilities of personal music players and assessment of preferred listening levels of test subjects: Outlining recommendations for preventing music‐induced hearing loss
Authors: Breinbauer Hayo A. , Anabalón Jose L. , Gutierrez Daniela , Cárcamo Rodrigo , Olivares Carla , Caro Jorge 
Published: October 2012

AbstractObjectives/Hypothesis:Our goal was to assess the impact of personal music players, earphones, and music styles on output, the subject's preferred listening levels, and outline recommendations for the prevention of music‐induced hearing loss.Study Design:Experimental study. Personal music players' output capabilities and volunteers' preferred output levels were assessed in different settings. Based on current noise‐induced hearing loss exposure limits, recommendations were outlined.Methods:On three different devices and earphone types and 10 music styles, free field equivalent sound pressure output levels were assessed by applying a microphone probe inside the auditory canal. Forty‐five hearing‐healthy volunteers were asked to select preferred listening levels in different background noise scenarios.Results:Sound pressure output reached 126 dB. No difference was found between device types, whereas earbud and supra‐aural earphones showed significantly lower outputs than in‐ear earphones (P < .001). Three distinct music style groups were identified with as much as 14.4 dB difference between them. In silence, 17.8% of volunteers spontaneously selected a listening level above 85 dB. With 90 dB background noise, 40% selected a level above 94 dB. Earphone attenuation capability was found to correlate significantly with preferred level reductions (r = 0.585, P < .001). In‐ear and especially supra‐aural earphones reduced preferred listening levels the most.Conclusions:Safe‐use recommendations were outlined, whereas selecting the lowest volume setting comfortable remained the main suggestion. High background noise attenuating earphones may help in reducing comfortable listening levels and should be preferred. A risk table was elaborated, presenting time limits before reaching a risky exposure. Laryngoscope, 2012
An Integrative Perspective of Online Foraging Behavior with Search Engines
Authors: Flavián Carlos , Gurrea Raquel , Orús Carlos 
Published: October 2012

ABSTRACTWhile technology evolves rapidly, humans have to adapt to the environment. Evolutionary theories are proposed as an overarching framework to explain the information systems phenomena. However, there is a need to develop these theories in more realistic contexts, and to integrate them with nonevolutionary theories, in order to gain a better understanding of human–computer interactions. Searching entails uncertainty, and the feelings that it arouses may affect search behavior. This research aims to fill this gap by examining the impact of situational factors on online foraging with search engines, taking into account users’ behavior and their emotional responses during the process. The results stress the importance of the initial emotional state and the temporal dimension in shaping the online environment that determines the online search behavior.
Brand Attachment and Consumer Emotional Response to Unethical Firm Behavior
Authors: Schmalz Sebastian , Orth Ulrich R. 
Published: October 2012

ABSTRACTAttaching consumers to a brand is a cornerstone of relationship marketing as attachment increases loyalty. This research investigates another possible benefit of attachment, its potential and limits for shielding brands from firms’ ethical missteps. Merging motivated reasoning and attachment theories, two studies focus on how brand attachment influences consumer judgments of firm ethics and the emotional and behavioral consequences developing from those. A field study indicates that attachment attenuates judgments of unethical behavior, contributes to emotional ambivalence, and affects purchase intentions. A subsequent experiment corroborates these findings and shows that the buffering role of attachment is limited to conditions when the information about firm ethics is moderately rather than extremely negative. Implications focus on advancing research on ethics and emotional ambivalence in consumer brand relationships and on managerial implications.
Who Likes Bratz? The Impact of Girls’ Age and Gender Role Orientation on Preferences for Barbie Versus Bratz
Authors: Karniol Rachel , Stuemler‐Cohen Tamara , Lahav‐Gur Yael 
Published: October 2012

ABSTRACTWhy did Bratz dolls appeal to young girls? To answer this question, sixty Israeli girls, 6–11 years old, completed Boldizar's (1989) Children's Sex Role Inventory (CSRI) and were later asked how many Barbies and Bratz dolls they have. After being shown pictures of a Barbie and a Bratz doll, they were asked as to their preference, justified their preference, and explained why girls in general like the dolls. Feminine girls indicated having a larger number of dolls of both types and all girls reported having more Barbies; yet nearly all girls reported preferring to play with Bratz. Feminine girls were least likely to offer positive descriptors of Bratz dolls. The dolls’ beauty was more often cited as reasons for younger girls’ liking both dolls, and such explanations were independent of girls’ gender role orientation. Gender role orientation did not impact any of the categories of preference justification for Barbie, but it did impact justifications for liking Bratz, with androgynous and undifferentiated girls more often citing Bratz's clothes as justifications for liking the doll. The data indicate that Bratz's appearance and clothing appealed primarily to girls with nontraditional gender role orientations.
Positive temperature coefficient to resistively characteristics of polystyrene/nickel powder/multiwall carbon nanotubes composites
Authors: Kar Prativa , Maiti Sandip , Shrivastava Nilesh K. , Dhibar Saptarshi , Khatua B.B. 
Published: October 2012

AbstractPositive temperature coefficient to resistivity (PTCR) characteristics of polystyrene (PS)/Ni‐powder (40 wt%) composites in the presence of multiwall carbon nanotubes (MWCNTs) has been investigated with reference to PS/carbon black (CB) composites. The PS/CB (10 wt%) composites showed a sudden rise in resistivity (PTC trip) at ≈110°C, above the glass transition temperature (Tg) of PS (Tg ≈95°C). Interestingly, the PTC trip temperature of PS/Ni‐powder (40 wt%)/MWCNT (0.75 phr) composites appeared at ≈90°C (below Tg of PS), indicating better dimensional stability of the composites at PTC trip temperature. The PTC trip temperature of the composites below the Tg of matrix polymer (PS) has been explained in terms of higher coefficient of thermal expansion (CTE) value of PS than Ni that led to a disruption in continuous network structure of Ni even below the Tg of PS. The dielectric study of PS/Ni‐powder (40 wt%)/MWCNT (0.75 phr) composites indicated possible use of the PTC composites as dielectric material. Dynamic mechanical analysis (DMA) and thermogravimetric analysis studies revealed higher storage modulus and improved thermal stability of PS/Ni‐powder (40 wt%)/MWCNT (0.75 phr) composites than the PS/CB (10 wt%) composites. POLYM. COMPOS., 33:1977–1986, 2012. © 2012 Society of Plastics Engineers
Maternal serum second trimester screening for chromosomal disorders and neural tube defects in a government hospital of North India
Authors: Kaur Gurjit , Srivastav Jyoti , Kaur Avneet , Huria Anju , Goel Poonam , Kaur Ravinder , Kataria Sandeep , Chavan Bir Singh , Kochhar Suman , Aggarwal Purnima , Kaur Narinder , Panigrahi Inusha , Chawla Pawandeep 
Published: October 2012

ABSTRACTObjectiveDown syndrome (DS) has major resource implications especially in developing countries being third most important cause of mental handicap. Maternal serum screening for chromosomal aneuploidies and neural tube defects (NTDs) is practiced worldwide in many countries and has been integrated into mainstream health care, while it is gradually gaining momentum in Asian countries.MethodsThis prospective cohort study was carried out in pregnant women undergoing triple screening test between January 2007 and December 2010 after informed consent. Biomarkers alpha‐fetoprotein, human‐chorionic‐gonadotropin and unconjugated‐estriol were tested, and risk of pregnancy being affected with DS, Edward's syndrome or NTDs were calculated. Screen‐positive patients were referred for detailed ultrasonography and confirmatory amniocentesis. Follow‐up record was maintained until delivery.ResultsOf 7400 pregnant women enrolled, 419(5.7%) were screen‐positive, including 339 positive for DS, two for trisomy 18, and 62 for NTDs. Total eight cases of DS were eventually diagnosed in the population (prevalence of DS = 1 : 925), seven of which were detected in utero following diagnostic evaluation for positive serum screen (DR of DS screen = 87.5%). Total five cases of NTD were observed, yielding NTD prevalence of 0.67/1000.ConclusionsTriple screening in the second trimester is reasonably effective for the detection of major chromosomal defects and NTDs, and can be implemented successfully also in India. © 2012 John Wiley & Sons, Ltd.