bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicentric Castleman's Disease Associated with Inherited Epidermolysis Bullosa
Authors: Kawakami Yoshio , Nishibu Akiko , Kikuchi Satoshi , Ohtsuka Mikio , Nakamura Koichiro , Nozawa Yoshihiro , Abe Masafumi , Iwatsuki Keiji , Kaneko Fumio 
Published: July 2014

AbstractMulticentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43‐year‐old patient with dystrophic EB, non‐Hallopeau‐Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin‐6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.
Bullous Scabies Mimicking Bullous Pemphigoid
Authors: Brar Balvinder Kaur , Pall Anuj , Gupta Rajesh Rani 
Published: July 2014

AbstractScabies is an infestation caused by Sarcoptes scabiei and characterised by polymorphous lesions that may include burrows, papules, nodules, excoriation and crusts. Vesicular and bullous lesions are rather rare. Several diseases may be confused with scabies. We report a case of bullous scabies which, on the basis of the clinical and histopathological picture, mimicked bullous pemphigoid. Direct and indirect immunofluorescence were negative. Bullae recurred and persisted despite systemic corticosteroids. The patient was successfully treated with 5% permethrin and remained disease free for up to 12 months of follow‐up.
Residual Washing Detergent in Cotton Clothes: A Factor of Winter Deterioration of Dry Skin in Atopic Dermatitis
Authors: Kiriyama Takashi , Sugiura Hisashi , Uehara Masami 
Published: July 2014

AbstractAlthough it is well known that the skin in patients with atopic dermatitis becomes drier in winter, the mechanisms of winter deterioration of dry skin are not fully understood. Our purpose was to determine whether residual washing detergent in cotton clothes plays a role in the winter deterioration of atopic dry skin. We studied 148 Japanese patients with atopic dermatitis who visited our dermatology clinic during winter months. They wore cotton underwear, which they had washed in cold tap water. We examined the distribution of dry skin on their trunks. We then asked them to stop washing their clothes with common anionic, additive‐enriched detergents, and to use a nonionic, additive‐reduced detergent for a period of two weeks. Photographs of 2 or 3 representative dry skin sites on the trunk were taken before and after the trial. By comparing the before‐after trial photographs, the severity of dry skin at the end of the trial was assessed on a 5‐point scale ranging from markedly improved to worsened. Of the 148 patients examined, 115 (78%) had widespread or localized dry skin on the trunk. The dryness of the skin was prominent around the shoulders. Of these 115 patients, 87 (76%) showed marked or moderate improvement of dry skin after the two‐weeks of use of the nonionic, additive‐reduced washing detergent. No patient showed worsening of the dry skin. These results suggest that residues of common washing detergents in cotton underclothes play an important role in the winter deterioration of dry skin in patients with atopic dermatitis who use cold tap water for washing their clothes.
Localized Cutis Marmorata Telangiectatica Congenita on the Back of a Young Man
Authors: Takenaka Hideya , Yasuno Hirokazu , Kishimoto Saburo 
Published: July 2014

AbstractWe report the clinical and light microscopic features of a case of cutis marmorata telangiectatica congenita with a painful refractory ulcer that was found on the back of a young Japanese man. The ulcer was positioned on the upper back over the spinal bone. In addition to the anatomical location of the ulcer, the vascular ectases may have played a part in the refractory ulceration.
Pulse Therapy with Amikacin and Dapsone for the Treatment of Actinomycotic Foot: A Case Report
Authors: Sharma Neelu , Mendiratta Vibhu , Sharma Ravi Chandra , Hemal Upma , Verma Monica 
Published: July 2014

AbstractActinomycetoma is a chronic disease caused by aerobic actinomycetes and affecting the skin, subcutaneous tissue, and bones. It causes significant morbidity and clinically manifests as abscesses and sinus/fistulae with or without granules. Early diagnosis is based on the color, size, histopathology of the granules; culture and metabolic studies are used for further species differentiation. Although sulfamethoxazole‐trimethoprim alone or in combination with dapsone for a variable period of time are used as first line agents for treatment, slow response to the therapy and high relapse rates have led to increasing usage of alternative agents like gentamycin, amikacin and cefotaxime. We report a case of actinomycetoma foot who had complete treatment failure with a sulfamethoxazole‐trimethoprim‐dapsone combination and was successfully treated with combination therapy of amikacin and dapsone without any side effects.
Acute Allergic Contact Dermatitis Due to Para‐Phenylenediamine after Temporary Henna Painting
Authors: Nawaf Al‐Mutairi , Joshi Arun , Nour‐Eldin Osama 
Published: July 2014

AbstractThe use of temporary natural henna painting for body adornment and hair dyeing is very common in several countries of the Indian subcontinent, Middle East, and North Africa, and the fad is spreading in other parts of the world. Several cases of para‐phenylenediamine (PPD) contaminated, temporary traditional/natural henna induced sensitization and acute allergic reaction have been reported, along with occasional serious long term and rare fatal consequences. We report here a 17‐year‐old girl with blisters over her hands of five‐days duration that appeared within 72 hours of applying a temporary henna paint to her hands during a social occasion. Similar lesions were noted on her face. She had previously applied black henna only once, a year earlier without developing any lesions. Clinical diagnosis of acute allergic contact dermatitis (ACD) was made. After a short course of oral corticosteroids, topical mometasone furaote 1.0% cream, and oral antihistamines, the lesions healed completerly over the next four weeks leaving post‐inflammatory hypopigmentation. Patch testing done with standard European battery, PPD 1% in petrolatum, and commercially available natural henna powder revealed a 3+ reaction to PPD at 48 hours. No reaction was seen at the natural henna site. Awareness of the condition among physicians and the public and regulation regarding warnings of the risks of using such products is urgently warranted.
A Case of Generalized Pustular Psoriasis Associated with Turner Syndrome
Authors: Kawakami Yoshio , Oyama Noritaka , Kishimoto Kazuhiro , Yamazaki Keiji , Nishibu Akiko , Nakamura Koichiro , Hoshi Satoshi , Kaneko Fumio 
Published: July 2014

AbstractWe report a 27‐year‐old Japanese woman with Turner syndrome who had generalized pustular psoriasis of the von Zumbusch type. She developed a febrile diffuse erythema and pustular eruption without any history of preceding psoriasis vulgaris or drug ingestion. Oral treatment with 3.2 mg/kg cyclosporin per day successfully resulted in rapid improvement, followed by a complete remission. To our knowledge, this is the first report describing the unusual coexistence of these two systemic disorders. We discuss a hormone imbalance that might have contributed to the predisposition to pustular psoriasis and difficulties in the management of the patent's treatment.
Polypoid Basal Cell Carcinoma on the Perianal Region: A Case Report and Review of the Literature
Authors: Misago Noriyuki , Narisawa Yutaka 
Published: July 2014

AbstractWe report the case of an 88‐year‐old Japanese woman with polypoid BCC on the perianal region. The basaloid, solid aggregations of BCC were limited to the upper to middle part of the polypoid area. A review of the English and Japanese literature that excluded cases of fibroepithelioma of Pinkus found 21 total cases in which the polypoid BCC could be recognized as a variant of nodular BCC. The following points were used to categorize the lesions: 1) characteristic polypoid appearance that often mimics clinically benign or malignant adnexal neoplasms, melanocytic nevus, or malignant melanoma; 2) the peculiar favorable locations such as scalp (23.8% of the 21 cases), genital area (23.8% of the cases), and back‐buttock areas (19% of the cases). These areas suggest that etiologic factors other than ultraviolet radiation exposure are involved in such cases. These characteristic locations may also be the main reason why fibroepithelioma of Pinkus type BCCs frequently manifest with a polypoid appearance, because these types of BCCs also have similar preferred sites such as the back‐buttock and genital areas. Polypoid BCCs appear to affect more women than men than do nodular BCCs (7 men and 14 women). Although the polypoid BCCs have a large average size, they are not considered aggressive because the lesions are well‐circumscribed and the growth patterns are non‐infiltrative.
Delayed Diagnosis in a Case of Lupus Vulgaris with Unusual Localization
Authors: Ceylan Can , Gerceker Bengu , Ozdemir Fezal , Kazandi Alican 
Published: July 2014

AbstractLupus vulgaris is the most common form of cutaneous tuberculosis, and the usual sites of involvement are the head and neck. We present a forty‐six‐year‐old woman with lupus vulgaris on the external surface of the left leg and foot, an unusual site. Based on histopathological and clinical features, this case was diagnosed as lupus vulgaris with unusual localization.
Distal Phalangeal Metastasis of Extramammary Paget's Disease
Authors: Umebayashi Yoshihiro 
Published: July 2014

AbstractA rare case of phalangeal metastasis of extramammary Paget's disease in a 68‐year‐old man is described. The patient developed an erythematous, slightly elevated area in the pubic region. A biopsy specimen demonstrated numerous, large, rounded cells with ample pale‐staining cytoplasm proliferating in the epidermis. With a diagnosis of ***extra‐mammary Paget's disease, he underwent wide local excision and inguinal node dissection. Eleven months postoperatively, the patient developed a tender, red, swollen right ring finger. Bone X‐ray showed that the distal phalanx of the ring finger had completely dissolved. Histopathological examination demonstrated proliferation of tumor cells in the adipose tissue. They had poorer and darker cytoplasm than the Paget's cells in the epidermis of the pubic region. Immunohistochemically, these cells showed the same staining pattern as did the Paget's cells at the primary site. Accordingly, the patient was diagnosed with distal phalangeal metastasis of extramammary Paget's disease. Two weeks after the appearance of the distal phalangeal metastasis, the patient died of cancerous pleurisy. It has been reported that patients with phalangeal metastasis have a very poor prognosis.
Calcium Dobesilate (Cd) in Pigmented Purpuric Dermatosis (PPD): A Pilot Evaluation
Authors: Agrawal Subhav Kumar , Gandhi Vijay , Bhattacharya Sambit Nath 
Published: July 2014

AbstractPigmented purpuric dermatosis (PPD) is a chronic disorder of unknown etiology. It is quite common, and no therapy is significantly effective. Calcium dobesilate (Cd) has been tried successfully in many vascular disorders. The aim of this study was to evaluate the usefulness and efficacy of Cd in PPD. Nine male patients (7 with Schamberg's and 1 each with lichenoid dermatosis of Gougerot and Blum and lichen aureus) were given Cd 500 mg twice daily for two initial weeks and then 500 mg once daily for a total period of three months. All the patients were followed up for one year after cessation of therapy. The improvement was moderate in 11.11% and mild in 66.67% of cases; 22.22% did not show any improvement. New lesions stopped appearing in two weeks in all patients, and itching also improved in symptomatic cases without any significant side effects. Based upon the results of this pilot study we recommend Cd as the first line therapy for PPD.
Unilateral Nevoid Telangiectasia
Authors: Karakaş Mehmet , Durdu Murat , Sönmezoğlu Selma , Akman Ayşe , Gümürdülü Derya 
Published: July 2014

AbstractUnilateral nevoid telangiectasia is a cutaneous condition consisting of congenital or acquired patches of superficial telangiectases in a unilateral linear distribution. Unilateral nevoid telangiectasia has been associated with elevations of blood estrogen levels and/or an increased number of estrogen receptors in the involved skin. We present a hepatitis‐B carrier case with unilateral nevoid telangiectasia on the face and the right side of the neck; she had normal blood estrogen and a normal number of estrogen receptors in the involved skin.
Bilateral Lichen Striatus
Authors: Kurokawa Motoki , Kikuchi Hidezumi , Ogata Katsumi , Setoyama Mitsuru 
Published: July 2014

AbstractWe describe a very rare case of bilateral lichen striatus on the lower extremities with a history of more than ten years. Histopathologically, the lesions demonstrated a lichenoid tissue reaction with foci of spongiosis and perivascular inflammatory cell infiltration. In addition, the finding of lymphocytic infiltrations around the eccrine duct was observed. They were treated successfully with topical application of corticosteroid ointment. To the best of our knowledge, no other lichen striatus case has been reported with bilateral distribution and such long‐term persistence.
Idiopathic Unilateral Hyperhidrosis with Holmes‐Adie Syndrome: Case Report
Authors: Coskun Basak Kandi , Saral Yunus , Belirgen Sait , Öztürk Perihan 
Published: July 2014

AbstractHyperhidrosis is a disease that is characterized by excessive sweating due to hyperactivation of eccrine sweat glands. It may be localized or generalized form. Holmes‐Adie syndrome is an idiopathic disease with unilateral pupil dilatation and loss of deep tendon reflexes. We present a 37‐year‐old female patient diagnosed with unilateral hyperhidrosis coincident with Holmes‐Adie syndrome because of this unusual presentation.
Bednar Tumor: A Report of Two Cases
Authors: Yagi Yoichi , Ueda Koichi , Maruyama Seichi , Noborio Reiko 
Published: July 2014

AbstractWe have recently treated two Japanese with Bednar tumor, pigmented dermatofibrosarcoma protuberans. The tumors were multilobular with brown‐pigmentation and an irregular surface. Firm nodules were growing into the deep subcutaneous tissue, but they were movable over the underlying tissue. Histopathological examination and immunohistochemical studies showed the typical features of Bednar tumor and positive staining for CD34, which is known to be expressed in dermatofibrosarcoma protuberans. Bednar tumor is thought to be a variant of dermatofibrosarcoma protuberans and to have intermediate malignancy.
Report of an Infant with Noma (Cancrum Oris)
Authors: Yuca Köksal , Yuca Sevil Arı , Çankaya Hakan , Çaksen Hüseyin , Çalka Ömer , Kırış Muzaffer 
Published: July 2014

AbstractNoma (cancrum oris) is an infectious disease that destroys the oro‐facial tissues and other neighboring structures in its fulminating course. The starting point of the disease is acute ulcero‐necrotic gingivitis, which results in an extensive gangrenous plaque destroying all of the soft tissues of the face. It predominantly affects children aged 2–16 years and is primarily seen in areas where the socioeconomic standards are low and there is poor hygiene, as in developing countries. We discuss possible predisposing factors in cancrum oris such as malnutrition, infectious diseases, HIV infection, and immune compromise conditions. Poverty is the most important risk factor. We report the case of a 6‐month‐old child with noma and review the characteristic features of this disease.
Cutaneous Sporotrichosis with Refractory and Reinfectious Lesions in a Healthy Female
Authors: Shinogi Taro , Misago Noriyuki , Narisawa Yutaka 
Published: July 2014

AbstractWe report a 71‐year‐old Japanese healthy female with an unusual clinical course of sporotrichosis; she developed infectious lesions on the face and the left upper limb at different periods. The initial lesion appeared on her right cheek and nose in 1992. Histopathologic and fungal examinations comfirmed the diagnosis of sporotrichosis. She was treated with oral potassium iodide and/or itraconazole and topical heat therapy. She had three recurrences and her facial plaque, which was resistant to several conventional treatments, was eventually excised and then grafted in 1996. After the surgical procedure, oral medication was continued for two months. In 2001, new lesions appeared on her left hand and forearm, which were anatomically different from the former lesions. Based on histopathologic and mycological findings, we confirmed reinfection with sporotrichosis. She was again treated with potassium iodide. The cutaneous lesions completely resolved after 26 weeks without surgical treatment.
Acute Generalized Exanthematous Pustulosis in a Six‐Year‐Old Boy
Authors: Lee Un Ha , Yang Jung Hun , Choi Jung Chul , Chun Duk Kyu 
Published: July 2014

AbstractAcute generalized exanthematous pustulosis (AGEP) presents with an abrupt onset of widespread pustules on erythematous base and rapid spontaneous healing. AGEP may have a variety of causative factors such as drugs, viral infection and exposure to mercury. We report a case of AGEP in a 6‐year‐old boy who presented with acute onset of fever and widespread pustular eruption on erythematous bases. Histologic examination showed neutrophilic subcorneal spongiform pustule. It is an uncommon condition in children.
Elevated Serum Antimelanocyte Antibody Level in Cerebriform Intradermal Nevus with Vitiligo
Authors: Lee Chih‐Hung , Yu Hsin‐Su 
Published: July 2014

AbstractWe describe a rare, but typical case of cerebriform intradermal nevus associated with vitiligo. A 45‐year‐old man had a patch of alopecia over his vertex scalp for 15 years. The microscopic findings of the biopsy revealed a typical deep‐seated intradermal nevus and neuroid differentiation with a few pigments. Three hypopigmented patches developed on the forehead, cheek and index finger five years after the scalp lesion, with loss of both melanocytes and melanins. In addition, no dopa reactions were present. Compared to normal controls, the serum antimelanocyte antibody level in the patient was elevated as determined by cellular enzyme‐linked immunosorbent assay (cellular ELISA). This is the first reported case with elevation of serum antimelanocyte antibody level of cerebriform intradermal nevus with vitiligo. This antibody's presence may be related to the occurrence of the vitiligo in patient with cerebriform intradermal nevus.
Lupus Panniculitis with Combined Features of Dermatomyositis Resulting in Severe Lipoatrophy
Authors: Yoo Jong Yeop , Jo Seong Jin , Cho Kwang Hyun 
Published: July 2014

AbstractAn 11‐year‐old girl presented with a one‐year history of multiple, hard, slightly painful subcutaneous nodules on her right cheek, upper arms, and buttock. Histology of a skin biopsy specimen showed a lobular panniculitis. Laboratory studies revealed positive ANA, anti‐double strand DNA, and elevated muscle enzymes. She was diagnosed as having lupus panniculitis. During hydroxychloroquine treatment, erythema over knuckle joints developed. These unusual clinical and laboratory findings of panniculitis associated connective tissue diseases made it difficult to make a precise diagnosis. We report this unusual case of lupus panniculitis with combined features of dermatomyositis resulting in severe lipoatrophy.
High‐Frequency Ultrasound as a Useful Device in the Preliminary Differentiation of Lichen Sclerosus et Atrophicus from Morphea
Authors: Chen Hsin‐Chi , Kadono Takafumi , Mimura Yoshihiro , Saeki Hidehisa , Tamaki Kunihiko 
Published: July 2014

AbstractHigh‐frequency ultrasound diagnostic equipment (HFUS) using probes with frequencies above 15‐MHz has been utilized conventionally in preoperative assessments and postoperative follow‐up of skin tumors. The advent of probes with even higher frequencies (up to 30‐MHz) has widened the clinical applications of HFUS to inflammatory dermatoses which are histologically confined to the epidermis and upper dermis, such as psoriasis and atopic dermatitis. Ultrasound imaging has the advantage of being a noninvasive and relatively inexpensive technology that is quick and easy to perform. In addition, information obtained from HFUS is unique and useful for clinical diagnosis and evaluation for various skin disorders. We believe that HFUS has the potential to become a powerful tool for either clinical or investigative dermatology. Herein, we present a case of lichen sclerosus et atrophicus (LSA) to which we applied HFUS before skin biopsy and obtained substantial information for the differential diagnosis from morphea, and we reemphasize the usefulness of HFUS in studying the inflammatory skin disorders.
Clinico‐Histopathological Correlation of Skin and Nerve in Leprosy
Authors: Khan Anamita , Koranne Ravinder V. , Bajaj Pramila , Ravi Bina 
Published: July 2014

AbstractThe histopathological features of skin tissue sections in patients clinically diagnosed as leprosy were correlated with the histopathological features of nerve specimens obtained from the same patients. Fifty untreated leprosy patients attending the Outpatient Department of the Department of Dermatology and Sexually Transmitted Diseases of Smt. Sucheta Kriplani and Kalawati Saran Children's Hospitals, New Delhi, India were included in the study. On correlating the histological features of skin and nerve tissue sections, concordant findings were found in 24 out of the 50 patients (48%) but discordance between the histopathological features of skin and nerve tissue sections were found in 26 out of 50 cases (52%). Of these 26 cases, the nerve tissue histology when compared with the skin histology showed features lower down the disease spectrum in 17 (34%) cases. Seven of the 50 patients (14%) showed histological features of leprosy higher in the disease spectrum in the nerve tissue sections than in the skin biopsy sections. One patient clinically LL leprosy demonstrated histopathological features of Histoid leprosy in the skin sections and LL in the nerve sections. The remaining one patient had features of TT leprosy in the skin tissue sections while the nerve tissue histopathology showed non‐specific changes. Histological features of the skin tissue sections were consistent with the clinical diagnosis in 33 out of 50 cases (66%). When the clinical groups were correlated with the histological features of the nerve tissue sections, concordance was found in 30 of the 50 cases (60%). On comparison of the histological features of skin and nerve tissue sections with the clinical diagnosis, concordance was still lower i.e., 19 out of 50 cases (38%). Thus the histological features of the skin tissue sections correlated more frequently with the clinical diagnosis than did those of the nerve sections. The importance of neural histology lies in the fact that it shows a higher BI and a lower histological grading in some cases and if not performed the lapse can result in inadequate treatment, drug resistance and even relapse.