bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and psychometric evaluation of a pneumatic tourniquet work standards scale
Authors: Fanoudi Hamideh , Torabizadeh Camellia , Rakhshan Mahnaz , Shahcheraghi Gholam Hossain 
Published: July 2024

Abstract
Objective
Pneumatic tourniquets are among the most essential equipment for controlling bleeding in orthopedic surgeries. However, incorrect application of pneumatic tourniquets is accompanied by many hazards and complications for patients. Evaluation of surgical teams’ use of pneumatic tourniquets and establishment of protocols can play an important role in improving patient safety, minimizing risks, and increasing the lifetime of this equipment. Accordingly, the present study was conducted to develop and assess the psychometric properties of a pneumatic tourniquet work standards scale.

Methods
The present study is a methodological work carried out in two stages. In the first stage, an initial version of the scale was developed based on existing research and panel reviews. In the second stage, the psychometric properties of the scale were tested in terms of face validity (measured qualitatively and quantitatively), content validity (measured qualitatively and quantitatively), item analysis, construct validity, and reliability (internal consistency and stability).

Results
The initial version of the scale consisted of 91 items. After several meetings of the research team, the number of items decreased to 81. In the course of face and content validity testing, 40 items were eliminated, leaving 41 items on the scale when it entered the construct validity testing stage. For evaluation of construct validity, a sample of 300 operating room nurses was recruited. The Exploratory Factor Analysis (EFA) results showed a structure supported by seven factors and 41 items. The reliability of the scale was confirmed by internal consistency analysis, with a good Cronbach’s alpha (0.85), and test–retest analysis, with good values of ICC (0.95).

Conclusion
The present instrument is a reliable and valid scale which fills the gap in assessment of surgical team members’ use of pneumatic tourniquets. The developed scale can be employed by researchers and managers of medical centers to identify hazards in applying pneumatic tourniquets and devise educational programs to eliminate or reduce the existing issues.
Early functional recovery outcomes and return to work after primary total hip arthroplasty: a novel patient reported outcomes questionnaire
Authors: Fawley David , Bernard Thierry , Thomason Henry Clayton , Zagra Luigi , ten Broeke René H.M. , Johnson Kory 
Published: July 2024

Abstract
Purpose
Clinical and patient reported outcomes are often collected before and after the procedure to benchmark and study outcomes for patients. These outcomes and scores are useful for tracking patient outcomes after surgery, however, the fact that these commonly used measures typically provide information about a patient’s level of pain and function at a single point in time is a limitation.

Methods
We present early functional recovery and return to work outcomes after primary THA from a novel questionnaire administered in a global, multi-center, prospective clinical study.

Results
By 6 and 12 weeks post-op, a large proportion of study subjects were able to perform functional recovery outcomes after their THA: walk without an aid (74%; 94%); drive (76%; 97%); basic activities of daily living (94%; 99%); perform light household duties (91%; 96%); perform moderate-to-heavy household duties (54%; 86%); go up and down a flight of stairs (92%; 99%); put on socks/stockings (77%; 93%); bend down to pick up an object from the floor (87%; 97%); stand up from a chair (96%; 99%); perform leisure recreational activities (54%; 84%); perform primary goal identified pre-THA (69%; 86%). 60% were able to return to work by 12 weeks post-op. These questions showed strong association with the Forgotten Joint Score.

Conclusion
Excellent patient reported early functional recovery outcomes and satisfaction were observed at 6- and 12-weeks post-op in this cohort and is the first reported data using a novel PRO.

Clinical trial registration
NCT03189303, registered June 14, 2017.
Non-intubated tracheal resection and reconstruction for a tracheal tumor in an 8-year-old child
Authors: Zhang Yaoliang , Mo Zhongqiao , Yang Chao , He Jianxing , Li Shuben , Lan Lan 
Published: July 2024

Abstract
Introduction
It has been reported that non-intubated anesthesia can be used successfully in adult trachea reconstruction. Herein, our center reported a case of a child undergoing non-intubated trachea reconstruction for benign tracheal tumors.

Case description
In January 2023, it was decided to attempt tracheal resection and reconstruction (TRR) in an 8-year-old child with an inflammatory myofibroblastic tumor under non-intubated spontaneous breathing. After anesthesia induction, the laryngeal mask airway (LMA) was inserted. Thereafter, a bilateral superficial cervical plexus block was performed with 15 mL of 0.25% ropivacaine injected into each side. The patient was induced to resume spontaneous breathing by artificially assisted ventilation with an oxygen flow of 2 to 5 L/min and FiO2=1. After tracheotomy, the oxygen flow was increased to 15 L/min to improve the local oxygen flow to maintain the pulse oxygen saturation (SpO2) above 90% under spontaneous breathing. The patient had stable spontaneous breathing after tracheal anastomosis. The anastomosis was perfect without leakage. The LMA was removed and oxygen was given by the nasal catheter under light sedation at post anesthesia care unit (PACU).

Conclusion
Tracheal reconstruction under spontaneous breathing may be an alternative anesthesia method for upper tracheal surgery in children.
A morpho-phylogenetic update on ixodid ticks infesting cattle and buffalos in Vietnam, with three new species to the fauna and a checklist of all species indigenous to the country
Authors: Hornok Sándor , Farkas Róbert , Duong Ngoc Nhu , Kontschán Jenő , Takács Nóra , Keve Gergő , Pham Duan Ngoc , Dao Thanh Thi Ha 
Published: July 2024

Abstract
Background
Southeast Asia is regarded as a hotspot for the diversity of ixodid ticks. In this geographical region, Vietnam extends through both temperate and tropical climate zones and therefore has a broad range of tick habitats. However, molecular-phylogenetic studies on ixodid tick species have not been reported from this country.

Methods
In this study, 1788 ixodid ticks were collected from cattle, buffalos and a dog at 10 locations in three provinces of northern Vietnam. Tick species were identified morphologically, and representative specimens were molecularly analyzed based on the cytochrome c oxidase subunit I (cox1) and 16S rRNA genes. Fifty-nine tick species that are indigenous in Vietnam were also reviewed in the context of their typical hosts in the region.

Results
Most ticks removed from cattle and buffalos were identified as Rhipicephalus microplus, including all developmental stages. Larvae and nymphs were found between January and July but adults until December. Further species identified from cattle were Rhipicephalus linnaei, Rhipicephalus haemaphysaloides, Amblyomma integrum and Haemaphysalis cornigera. Interestingly, the latter three species were represented only by adults, collected in one province: Son La. The dog was infested with nymphs and adults of R. linnaei in July. Phylogenetically, R. microplus from Vietnam belonged to clade A of this species, and R. haemaphysaloides clustered separately from ticks identified under this name in China, Taiwan and Pakistan. Amblyomma integrum from Vietnam belonged to the phylogenetic group of haplotypes of an Amblyomma sp. reported from Myanmar. The separate clustering of H. cornigera from Haemaphysalis shimoga received moderate support.

Conclusions
Three tick species (R. linnaei, A. integrum and H. cornigera) are reported here for the first time in Vietnam, thus increasing the number of indigenous tick species to 62. Clade A of R. microplus and at least R. linnaei from the group of Rhipicephalus sanguineus sensu lato occur in the country. There is multiple phylogenetic evidence that different species might exist among the ticks that are reported under the name R. haemaphysaloides in South and East Asia. This is the first report of A. integrum in Southeastern Asia.

Graphical Abstract
The logarithmic Sobolev inequality on the Heisenberg group and applications to the uncertainty inequality and heat equation
Authors: Suguro Takeshi 
Published: July 2024

AbstractWe consider the logarithmic Sobolev inequality on the Heisenberg group. One can derive the logarithmic Sobolev inequality from the Sobolev inequality, and we consider an application to the uncertainty inequality on the Heisenberg group. Moreover, one can also obtain a dissipative estimate of a solution of the heat equation on the Heisenberg group from the logarithmic Sobolev inequality.
Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway
Authors: Chen Yang , Bao Shujun , Wang Zhongzhao , Fang Zheng , Tang Hao 
Published: July 2024

Abstract
Background
Cisplatin (DDP) chemotherapy is commonly used in therapy for non-small cell lung cancer (NSCLC), but increased drug resistance has become a huge obstacle. Baicalin (BA) contributed to the sensitivity of NSCLC to DDP. Here, we aimed to further probe the pathophysiological mechanisms of BA in NSCLC.

Methods
A549 and A549/DDP cells and xenograft mice were treated with BA and DDP. Xenograft mice were treated additionally with the NRF2 inducer (Bardoxolone methyl, BM) and KEAP1 knockdown. The levels of ferritinophagy-related proteins and biomarkers were determined. The autophagosomes were observed. M1 macrophage polarization and the contents of related indicators were analyzed. The involvement of KEAP1/NRF2/HO-1 was determined.

Results
BA inhibited cell development, and the effect of BA and DDP on cell development was additive. The abundance of ferritinophagy-related proteins and the number of autophagosomes were induced by BA. BA also promoted the transition of GSH to GSSH. BA favored M1 macrophage polarization and affected the expression of related proteins. When BA and DDP combined, these molecular phenomena were further exacerbated. BA induced accumulation of KEAP1 and reduction of NRF2 and HO-1. However, BM and KEAP1 knockdown disrupted the synergistic effects of BA and DDP on inhibiting NSCLC growth. BM and KEAP1 knockdown reversed DDP and BA-promoted protein expression activity and M1 macrophage polarization.

Conclusion
Our findings suggest that BA is involved in ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 axis, thereby improving the DDP sensitivity in NSCLC, which could provide new candidates for treatment strategies.
METTL16 regulates the mRNA stability of FBXO5 via m6A modification to facilitate the malignant behavior of breast cancer
Authors: Wang Runying , Gao Xingjie , Xie Luhan , Lin Jiaqi , Ren Yanying 
Published: July 2024

Abstract
Background
N6-methyladenosine (m6A) regulates the progression of breast cancer (BC). We aimed to investigate the action and mechanism involved of methyltransferase-like protein 16 (METTL16) in BC growth and metastasis.

Methods
RT-qPCR, immunoblotting, and IHC were performed to test the levels of gene expression. CCK-8, clone formation, wound healing, and transwell assays were applied to measure the cell proliferation, migration, and invasion. m6A RNA methylation and MeRIP assay were utilized to confirm the m6A level of total RNA and FBXO5 mRNA. RIP was utilized to ascertain the interaction between METTL16 and FBXO5 mRNA. The in vivo murine subcutaneous tumor and metastasis model were constructed to further confirm the action of METTL16.

Results
METTL16 was overexpression in BC cells and tissues. Inhibition of METTL16 restrained the growth and metastasis of BC. Furthermore, the METTL16 level and FBXO5 level was positively correlated in BC tissues, and METTL16 aggrandized the stability of FBXO5 mRNA depending on the m6A modification. Overexpression of FBXO5 antagonized the restrained function of METTL16 knockdown on BC cells’ proliferation, migration, invasion, and EMT.

Conclusion
METTL16 boosts the mRNA stability of FBXO5 via m6A modification to facilitate the malignant action of BC in vitro and in vivo, offering new latent targets for cure of BC.
Numerical simulation and analysis of a ducted-fan drone hovering in confined environments
Authors: Luo Yiwei , He Yuhang , Xu Bin , Ai Tianfu , Qian Yuping , Zhang Yangjun 
Published: July 2024

AbstractDucted-fan drones are expected to become the main drone configuration in the future due to their high efficiency and minimal noise. When drones operate in confined spaces, significant proximity effects may interfere with the aerodynamic performance and pose challenges to flight safety. This study utilizes computational fluid dynamics simulation with the Unsteady Reynolds-averaged Navier–Stokes (URANS) method to estimate the proximity effects. Through experimental validation, our computational results show that the influence range of proximity effects lies within four rotor radii. The ground effect and the ceiling effect mainly affect thrust properties, while the wall effect mainly affects the lateral force and the pitching moment. In ground effect, the rotor thrust increases exponentially by up to 26% with ground distance compared with that in open space. Minimum duct thrust and total thrust are observed at one rotor radius above the ground. In ceiling effect, all the thrusts rise as the drone approaches the ceiling, and total thrust increases by up to 19%. In wall effect, all the thrusts stay constant. The pitching moment and lateral force rise exponentially with the wall distance. Changes in blade angle of attack and duct pressure distributions can account for the performance change. The results are of great importance to the path planning and flight controller design of ducted-fan drones for safe and efficient operations in confined environments.
Mobile Health Technology for Personalized Tobacco Cessation Support Among Cancer Survivors and Caregivers in Laos: A Pilot Trial
Authors: Kulkarni Shweta , Xangsayarath Phonepadith , Soulaphy Chanthavy , Xayavong Dalouny , Phandouangsy Khatthanaphone , Keopaseuth Phayvanh , Alounlungsy Phetsamone , Le Tina N. , Vidrine Damon J. , Vidrine Jennifer I. , Le Phuc H. , Frank-Pearce Summer G. , Businelle Michael S. , Bui Thanh Cong 
Published: July 2024

PURPOSE In Laos, tobacco smoking prevalence among cancer patients is high: 60% in men and 15% in women. However, there are no institutional or national tobacco treatment programs for cancer patients or their caregivers. To address this pressing need, we developed an mHealth-based, fully-automated, interactive intervention to help these populations quit smoking. This pilot randomized controlled trial aims to evaluate the feasibility and preliminary efficacy of our mHealth intervention. METHODS Thirty cancer survivors and 50 independent caregivers were recruited from Lao National Cancer Center and Setthathirath Hospital in Vientiane Capital. Participants were randomized to Standard Care (SC, n=40) or Automated Intervention (AI, n=40). SC consisted of brief advice to quit, a 2-week supply of nicotine patches, and self-help materials. AI consisted of the SC components plus a smartphone-based fully-automated treatment program that involved interactive, tailored, proactive content (∼3 messages per day plus some images/videos) for a 3-month period. RESULTS Most participants belonged to Lao ethnicity (98.7%), 8.8% were female, and 57.5% lived in non-urban areas. There was a loss to follow-up at 3 months due to the death of a cancer patient. AI was acceptable: 61.5% of AI participants agreed that the Insight app was easy to use, 61.5% agreed that the message content was easy to understand, and 64.1% felt comfortable with opening the messages in public places. Regarding the preliminary efficacy, changes in self-efficacy to avoid smoking in various social situation (measured on a 5-point Likert scale) from baseline to the 3-month follow-up was 2.41 for AI and -0.04 for SC (paired t-test, P=0.516). Biochemically verified 7-day point prevalence abstinence at 3 months were 74% for AI and 40% for SC (relative risk, 1.85 [95% confidence interval, 1.21–2.83]). CONCLUSION Our mHealth-based AI for smoking cessation is acceptable and potentially efficacious among cancer survivors and caregivers in Laos. The observed quit rates for both groups at 3 months were considerably higher than rates in our previous studies in other Lao or Cambodian general patient populations, suggesting that cancer patients and caregivers, who are facing a real consequence of smoking (i.e., cancer), may be more determined to quit smoking.
Nanoparticle's Encapsulation As a Marker for Leading Cells in Collective Migration of Breast Cancer Cells
Authors: Alexandrova Anastasia , Kontareva Elizaveta , Pustovalova Margarita , Leonov Sergey , Merkher Yulia 
Published: July 2024

PURPOSE In 2020, there were 2.3 million women diagnosed with breast cancer. Deaths related to cancer occur due to metastasis. In most types of solid tumors, spreading happens through collective migration, guided by “cellular leaders.” Previously, we have shown that 100-200 nm nanoparticles encapsulated more efficiently by cells with high metastatic potential (MP) than by cells with low MP. The aim of the current research is to quantitatively compare the encapsulation ability between metastatic cells that act as leaders during migration, and peripheral cells. METHODS We used Wound Healing Assay to study collective migration in two cell lines: MCF7 and MDA-MB-231 (low and high MP respectively). Firstly, we conducted calibration experiments to find the “optimal time”, when the cells reach the maximal speed during wound closure. Further, the cells were incubated with 200nm fluorescent nanoparticles for one hour prior to the determined “optimal time”. Digital images were acquired using fluorescent microscopy and Fiji software. Colocalization of nanoparticles was calculated using Pearson coefficient. Statistical differences were performed using ANOVA. RESULTS The highest wound closure rate for low MP cells was reached in 2.6 hours and for high MP cells in 3.9 (8 and 11% of wound area closure respectively). The coefficients of nanoparticle encapsulation were 0.063±0.005 and 0.046±0.004 at the edge of the wound and at peripheral area, respectively, for cells with high MP 0.039±0.003 and 0.027±0.002 for low MP. We observed a significant difference in encapsulation efficiency between leading and peripheral cells for both, high and low MP cells (p<0.013). CONCLUSION We have found the “optimal time” of wound closure, with the increased migration activity for each tested cell type. We have demonstrated that encapsulation efficiency of leading cells is significantly higher than for peripheral cells. Therefore, nanoparticles encapsulation can be used as a potential marker for most aggressive and invasive, leading cells in collective migration of breast cancer cells.
Non Adherence to Post Surgery Annual Surveilance Mammogram and Follow Up Among Breast Cancer Survivors in a Tertiary Care Hospital in Malaysia
Authors: Siaw Jia Yng , Mohamad Zaman Siti Asmah , Neoh Shi Hui , Wan Ali Sharifah Ashrina , Modamad Tazuddin Estrellita Elena , Bujang Mohamad Adam , Teoh Li Ying , Islam Tania , Mohd Taib Nur Aishah 
Published: July 2024

PURPOSE The importance of surveillance mammogram and follow up post breast cancer surgery has been emphasised in most international and local guidelines including Malaysian Clinical Practice Guidelines (CPG). There is insufficient real-world data in Malaysia to assess the adherence to CPG guideline. This study aimed to determine the adherence rate and identify factors affecting patients adherence. Association between adherence to surveillance mammogram and follow up with survival rate is studied. METHODS 776 women with newly diagnosed stage 1 to 3 breast cancer in Sarawak General Hospital between January 2010 and December 2018 post breast cancer surgery were included in this study. Sociodemographic, clinical, tumour and treatment characteristics and follow up details were collected from clinic records. Factors associated with compliance to mammogram in the first three years were analysed using logistic regression. RESULTS The adherence to surveillance mammogram declined gradually from 84.9% at the 1st year, 78.1% at the 5th year and 38.1 at the 10th year. Non adherence to surveillance mammogram in the first 3 years post surgery was significantly associated with 4 independent factors: Charlson Co-Morbidity Index Score (CCI) of >2, [odd ratio (OR) 3.34, 95% confidence interval (CI) 1.17-9.52 for CCI >2 versus CCI of 0];disease staging [OR 2.18, 95% CI 1.12-4.22 for stage 3 breast cancer, and OR 2.00, CI 1.04-3.18 for stage 2b breast cancer versus stage 1 breast cancer];chemotherapy [OR 1.89, 95% confidence interval (CI) 1.09-3.25 for patients who do not have chemotherapy versus reference group] and completion of recommended adjuvant therapy [OR 2.70, 95% confidence interval (CI) 1.03-7.11 for patient who do not complete recommended adjuvant therapy versus reference group]. Non-adherent to the first three-year surveillance mammogram is associated with a poorer 5-year overall survival rate. CONCLUSION There is a decline in adherence rate to annual surveillance mammogram over time among breast cancer survivors. Future study on measures to improve adherence in these subgroups of patients is needed.
Patient-Centricity Meter: A Scoping Review of Measures of Patient-Centricity in Cancer Care in LMICs
Authors: Sun Cindy , Thakkar Diksha , Taylor Carolyn , Cabanes Anna 
Published: July 2024

PURPOSE Patient-centered healthcare systems respect the experience, values, needs, and preferences of people with cancer in the planning, coordination, and delivery of care. Patient centricity is an essential component of a functional health system and a key vehicle to achieve equitable access to healthcare of quality, at all resource levels. The core components of patient-centered care are patient participation and involvement; patient-provider relationship; and the setting where care is delivered. However, patient centricity is conceptualized differently in different settings and among different stakeholders, impacting the effective implementation and evaluation of patient-centered initiatives. The purpose of this study was to identify measures of patient centricity and patient-centered system performance used in the context of low-and middle-income countries (LMICs), analyzing a valid set of patient-centered indicators for settings with limited resources, as a first step towards improving the patient-centricity of cancer care. METHODS We examined published articles reporting measures of patient-centered care (PCC) or a component of PCC in LMICs. Following PRISMA guidelines, we performed a systematic search of PubMed, Cinhal, and Embase. We limited the scope to original research studies and evaluations focused on LMICs between January 2004 and December 2022. RESULTS Twenty-nine studies reported evaluations in cancer care in LMICs. Twenty eight were conducted in upper-middle income countries, one in a lower-middle income country, and none in low-income countries. Most studies measured patient centricity on cancer care in general, or were specific to breast cancer. The elements of patient centricity most frequently evaluated were patient satisfaction, and patient-centered care, and most studies used validated tools. Other domains of PCC - patients rights, quality of life, multidisciplinary care, and patient-provider communications - were seldom measured. CONCLUSION In LMICs - which carry the heaviest burden of cancer- there are critical gaps in the evaluation of patient centered cancer care, with most studies focusing on a few measures of patient centricity. To the best of our knowledge, this is the first review of this type. We hope to use these results to develop a set of indicators to evaluate the quality of patient-centered cancer care appropriate to each countrys health development level.