bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acyclic Amido‐Containing Silanechalcogenones
Authors: Chan Yuk‐Chi , Li Yongxin , Ganguly Rakesh , So Cheuk‐Wai 
Published: May 2015

AbstractReactions of the amidinate‐stabilized silicon(II) bis(trimethylsilyl)amide [LSiN(SiMe3)2], {L = PhC(NtBu)2, 1} with a stiochiometric amount of elemental sulfur, selenium and tellurium afforded the first stable silanechalcogenones comprising an acyclic amido substituent [L{N(SiMe3)2}Si=E] {E = S (2), Se (3) or Te (4)}. All compounds were characterized by X‐ray crystallography and multinuclear NMR spectroscopy. The results illustrate that these compounds possess some silicon–chalcogen double bond character.
Benzoato and Thiobenzoato Ligands in the Synthesis of Dinuclear Palladium(III) and ‐(II) Compounds: Stability and Catalytic Applications
Authors: Estevan Francisco , Ibáñez Susana , Ofori Albert , Hirva Pipsa , Sanaú Mercedes , Úbeda Ma Angeles 
Published: May 2015

AbstractNew palladium(III) compounds of formula Pd2[(C6H4)PPh2]2[OXC(C6H5)]2Cl2[3a(X = O);3b(X = S)] were obtained by the oxidation of the analogous palladium(II) ones with PhICl2and were characterized by31P,1H, and13C NMR spectroscopy at 223 K. Compound3awas also structurally characterized by single‐crystal X‐ray diffraction methods, which revealed a Pd–Pd distance of 2.5212(10) Å. DFT calculations were conducted to study the stability of all of these new palladium(III) and ‐(II) compounds with focus on the influence of the O↔S substitution of the donor atom in the ligand. The palladium(II) compounds Pd2[(C6H4)PPh2]2[OXC(C6H5)]2[2a(X = O),2b(X = S)] were also tested as precatalyst in two reactions: (1) the acetoxylation of 2‐phenylpyridine and (2) the room‐temperature 2‐phenylation of indoles. Compound2bis a better precatalyst than2ain the first reaction (4 h; isolated yield, 67.5 vs. 50.4 %). In the second catalytic reaction, isolated yields of 97 (10 h, substrate: 1‐methylindole) and 99 % (24 h, substrate: indole) were obtained with2aas the precatalyst, whereas2bgave low or no conversion.
Synthesis and Characterization of Frustrated Spin Ladders SrFe2S2O and SrFe2Se2O
Authors: Huh Sungjoon , Prots Yurii , Adler Peter , Tjeng Liu Hao , Valldor Martin 
Published: May 2015

AbstractChemical pressure was introduced by replacing Ba atoms with Sr atoms in the spin‐ladder compounds AEFe2Ch2O (AE = Ba, Sr; Ch = S, Se). Powders and small single crystals of SrFe2S2O and SrFe2Se2O were synthesized from SrO, Fe, and Ch (S, Se). X‐ray diffraction data were used to determine the crystal structures, which showed prominent magnetic ladderlike sublattices. The Mössbauer spectra of SrFe2S2O and SrFe2Se2O suggest the presence of localized divalent Fe ions in the FeCh3O structural units (distorted e3t23 configuration, S = 2). Single sharp hyperfine patterns at 5 K indicate the formation of simple antiferromagnetic ground states. The spin‐ordering transitions (TN) were determined by magnetic, resistivity, and specific heat data to be 216 and 228 K for SrFe2S2O and SrFe2Se2O, respectively. At ca. 540 K, both compounds exhibit a similar broad maximum in χ (Tχmax). In comparison with BaFe2S2O and BaFe2Se2O, the Sr homologues have higher Tχmax values, which suggest stronger intersite exchange interactions in accordance with the chemical pressure from the replacement of Sr atoms with Ba atoms. However, the lower Néel temperatures for the Sr homologues supports the idea that magnetic frustration is present, and it clearly has to be considered for this group of compounds.
Azonia Aromatic Cations by Ring‐Closing Metathesis: Synthesis of Azaquinolizinium Cations
Authors: Abengózar Alberto , Abarca Beatriz , Cuadro Ana M. , Sucunza David , Álvarez‐Builla Julio , Vaquero Juan J. 
Published: May 2015

AbstractA strategy based on a ring‐closing metathesis (RCM) reaction of pyridinium azadienes in the presence of the second generation Grubbs catalyst was employed as a new approach to synthesize the 1‐azaquinolizinium (pyrido[1,2‐a]pyrimidin‐5‐ium) heterocycle and some simple derivatives. This method was also successfully applied to the first reported synthesis of the benzo‐1‐azaquinolizinium (pyrimido[2,1‐a]isoquinolinium) cation by using the Hoveyda–Grubbs catalyst in Cl2CHCHCl2 at 130 °C.
Sulfate Anion as a pH‐Switchable Template: Three‐State Switchable Systems Based on Diamidocarbazoles
Authors: Bąk Krzysztof M. , Chmielewski Michał J. 
Published: May 2015

AbstractThe sulfate anion SO42– – one of the most powerful and versatile anionic templates – can be reversibly “switched off” in aprotic solvents by protonation to the very weakly binding anion HSO4–. This sharp ON/OFF behaviour opens new opportunities for switching and manipulation of anion templated supramolecular systems, such as reversible folding/unfolding, assembly/disassembly or induction of mechanical motions. As a proof of concept, two new acid/base switchable three‐state systems are presented here.
Wetted‐wall column study on CO2 absorption kinetics enhancement by additive of nanoparticles
Authors: Wang Tao , Yu Wei , Fang Mengxiang , He Hui , Xiang Qunyang , Ma Qinhui , Xia Menglin , Luo Zhongyang , Cen Kefa 
Published: May 2015

AbstractNanoparticles suspended in solutions are considered to have the potential to enhance gas‐liquid mass transfer and have been studied for gas separation. In order to reveal the mechanisms of kinetics enhancement, the diffusion and reaction process should be carefully examined. In this paper, CO2 absorption kinetics of amine‐based solutions with additive of SiO2 and Al2O3 nanoparticles were investigated by wetted‐wall column experiments. Measurements at different conditions, including solid loading, pressure, and solvent flow rate, show a significant enhancement on CO2 absorption kinetics. The experiment and model analysis indicate that the micro convective motion induced by particle Brownian movement plays a primary role in mass transfer enhancement. Three solutions, MEA, MDEA, and PZ which have different kinetics were selected to study the impact of nanoparticles on absorption kinetics of solutions with different reaction rate. It is interesting to find that the increased ratio of absorption kinetics by nanoparticle follows the same order with increased solvent reaction rate with CO2, which is PZ > MEA > MDEA. The wetted‐wall kinetic model indicates that a diffusion controlled kinetics for PZ solution could result in much more significant kinetic enhancement with additives of nanoparticles. By operation conditions optimization, the liquid side mass transfer rate of MEA solution can be increased over 15%.© 2015 Society of Chemical Industry and John Wiley & Sons, Ltd
An Involvement of PI3‐K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro‐Apoptotic Factors‐Induced Cell Death in Human Neuroblastoma SH‐SY5Y Cells
Authors: Jantas Danuta , Piotrowski Marek , Lason Wladyslaw 
Published: May 2015

ABSTRACTUndecylenic acid (UDA), a naturally occurring 11‐carbon unsaturated fatty acid, has been used for several years as an economical antifungal agent and a nutritional supplement. Recently, the potential usefulness of UDA as a neuroprotective drug has been suggested based on the ability of this agent to inhibit μ‐calpain activity. In order to verify neuroprotective potential of UDA, we tested protective efficacy of this compound against cell damage evoked by pro‐apoptotic factors (staurosporine and doxorubicin) and oxidative stress (hydrogen peroxide) in human neuroblastoma SH‐SY5Y cells. We showed that UDA partially protected SH‐SY5Y cells against the staurosporine‐ and doxorubicin‐evoked cell death; however, this effect was not connected with its influence on caspase‐3 activity. UDA decreased the St‐induced changes in mitochondrial and cytosolic AIF level, whereas in Dox‐model it affected only the cytosolic AIF content. Moreover, UDA (1–40 μM) decreased the hydrogen peroxide‐induced cell damage which was connected with attenuation of hydrogen peroxide‐mediated necrotic (PI staining, ADP/ATP ratio) and apoptotic (mitochondrial membrane potential, caspase‐3 activation, AIF translocation) changes. Finally, we demonstrated that an inhibitor of PI3‐K/Akt (LY294002) but not MAPK/ERK1/2 (U0126) pathway blocked the protection mediated by UDA in all tested models of SH‐SY5Y cell injury. These in vitro data point to UDA as potentially effective neuroprotectant the utility of which should be further validated in animal studies. J. Cell. Biochem. 116: 2882–2895, 2015. © 2015 Wiley Periodicals, Inc.
Chondrogenic Differentiation of Human Mesenchymal Stem Cells Results in Substantial Changes of Ecto‐Nucleotides Metabolism
Authors: Roszek Katarzyna , Porowińska Dorota , Bajek Anna , Hołysz Marcin , Czarnecka Joanna 
Published: May 2015

ABSTRACTMesenchymal stem cells (MSCs) are population of adult stem cells and attractive candidates for cartilage repair due to their chondrogenic potential. Purinergic compounds (purinergic receptors and ecto‐enzymes metabolizing nucleotides), together with nucleotides/nucleosides present in the extracellular environment, are known to play a key role in controlling the stem cells biological potential to proliferate and differentiate. Despite the available literature pointing to the importance of purinergic signaling in controlling the fate of MSCs, the research results linking nucleotides and ecto‐nucleotidases with MSCs chondrogenic differentiation are indigent. Therefore, the aim of presented study was the characterization of the ecto‐nucleotides hydrolysis profile and ecto‐enzymes expression in human umbilical cord‐derived MSCs and chondrogenically induced MSCs. We described substantial changes of ecto‐nucleotides metabolism and ecto‐enzymes expression profiles resulting from chondrogenic differentiation of human umbilical cord‐derived MSCs. The increased rate of ADP hydrolysis, measured by ecto‐nucleotidases activity, plays a pivotal role in the regulation of cartilage formation and resorption. Despite the increased level of NTPDase1 and NTPDase3 mRNA expression in chondrogenically induced MSCs, their activity toward ATP remains quite low. Supported by the literature data, we hypothesize that structure–function relationships in chondrogenic lineage dictate the direction of nucleotides metabolism. In early neocartilage tissue, the beneficial role of ATP in improving biomechanical properties of cartilage does not necessitate the high rate of enzymatic ATP degradation. J. Cell. Biochem. 116: 2915–2923, 2015. © 2015 Wiley Periodicals, Inc.
Rising temperatures and changing rainfall patterns in South Africa's national parks
Authors: van Wilgen Nicola J. , Goodall Victoria , Holness Stephen , Chown Steven L. , McGeoch Melodie A. 
Published: May 2015

ABSTRACTAir temperatures have increased globally over the past decades, while rainfall changes have been more variable, but are taking place. In South Africa, substantial climate‐related impacts are predicted, and protected area management agencies will need to respond actively to impacts. It is critical for management agencies to understand the way in which climate is changing locally to predict impacts and respond appropriately. Here, for the first time, we quantify observable changes in temperature and rainfall in South African national parks over the past five to ten decades. Our results show significant increases in temperatures in most parks, with increases being most rapid in the arid regions of the country. Increases in the frequency of extreme high temperature events were also most pronounced in these regions. These results are consistent with other climate studies conducted in these areas. Similar increases were identified for both minimum and maximum temperatures, though absolute minimum temperatures increased at greater rates than absolute maxima. Overall, rainfall trends were less obvious, but a decrease in rainfall was observed for the southern Cape (in three parks), and an increase was detected in one park. The observed temperature changes over the last 20–50 years have in several instances already reached those predicted for near future scenarios (2035), indicating that change scenarios are conservative. These results provide individual parks with evidence‐based direction for managing impacts under current and projected changes in local climate. They also provide the management agency with sub‐regional information to tailor policy and impact monitoring. Importantly, our results highlight the critical role that individual weather stations play in informing local land management and the concerns for parks that have no local information on changes in climate.
Compressive mechanical modulation alters the viability of growth plate chondrocytes in vitro
Authors: Kaviani Rosa , Londono Irene , Parent Stefan , Moldovan Florina , Villemure Isabelle 
Published: May 2015

ABSTRACTThe aim of this study was to investigate the effect of compressive modulation parameters (mode, magnitude, duration, as well as frequency and amplitude for cyclic modulation) on the viability of growth plate chondrocytes. Swine ulnar growth plate explants (n = 60) were randomly distributed among 10 groups: baseline (n = 1 × 6); culture control (n = 1 × 6); static (n = 3 × 6); and dynamic (n = 5 × 6). Static and dynamic samples were modulated in vitro using a bioreactor. Different compression magnitudes (0.1 MPa or 0.2 MPa), durations (12 h or 24 h), frequencies (0.1 Hz or 1.0 Hz), and amplitudes (30% or 100%) were investigated. Viability was assessed by automatic quantification of number of live/dead cells from confocal images of Live/Dead labeled tissues. Chondrocyte viability was found to be dependent on compression magnitude, duration, frequency, and amplitude in a way that increasing each parameter decreased viability in certain zones of growth plate. More specifically, proliferative and hypertrophic chondrocytes were found to be more sensitive to the applied compression. This study provides an in vitro protocol for studying the effects of compressive modulation on biomechanical and biological responses of growth plate explants, which will be useful in finding efficient and non‐detrimental parameters for mechanical modulation of bone growth exploited in scoliosis fusionless treatments. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1587–1593, 2015.
Socioeconomic determinants of overnight and weekend emergency department use for acute rhinosinusitis
Authors: Bergmark Regan W. , Ishman Stacey L. , Scangas George A. , Cunningham Michael J. , Sedaghat Ahmad R. 
Published: May 2015

Objectives/HypothesisPrior work has shown Medicaid and self‐pay insurance status is associated with emergency department (ED), rather than outpatient clinic, presentation for uncomplicated acute rhinosinusitis (ARS). We investigate whether the disparate use of ED resources for this nonemergent condition by patients with Medicaid and self‐pay insurance can be attributed to presentation overnight or on weekends.Study DesignCross‐sectional survey of 990,849 patients from the 2009 and 2010 National Hospital Ambulatory Medical Care Survey presenting to EDs with uncomplicated ARS. Patients with orbital and intracranial complications of ARS were excluded.MethodsUnivariate and multivariate associations identified demographic and socioeconomic characteristics, including insurance status, which were independently associated with overnight (between 5 pm and 7 am) or daytime weekend ED presentation for uncomplicated ARS.ResultsMedicaid or self‐pay insurance status was associated with evening/overnight ED presentation (odds ratio = 1.88, P =.018) in comparison to private or Medicare insurance. However, weekend daytime ED presentation was not associated with Medicaid or self‐pay insurance statuses (P = .144). Income and education levels of patients’ zip codes, taken as markers of socioeconomic status, were not associated with either evening/overnight or daytime weekend ED presentation for uncomplicated ARS (P > .05).ConclusionsARS patients with Medicaid or self‐pay status, previously shown to preferentially use EDs for uncomplicated ARS, were more likely to present for overnight ED care compared to patients with private insurance or Medicare. These findings suggest a potential lack of access to extended‐hours primary care during evenings and nights for Medicaid patients.Level of Evidence4 Laryngoscope, 125:2441–2446, 2015
Relation of allium vegetables intake with head and neck cancers: Evidence from the INHANCE consortium
Authors: Galeone Carlotta , Turati Federica , Zhang Zuo‐Feng , Guercio Valentina , Tavani Alessandra , Serraino Diego , Brennan Paul , Fabianova Eleonora , Lissowska Jola , Mates Dana , Rudnai Peter , Shangina Oxana , Szeszenia‐Dabrowska Neonila , Vaughan Thomas L. , Kelsey Karl , McClean Michael , Levi Fabio , Hayes Richard B. , Purdue Mark P. , Bosetti Cristina , Brenner Hermann , Pelucchi Claudio , Lee Yuan‐Chin Amy , Hashibe Mia , Boffetta Paolo , La Vecchia Carlo 
Published: May 2015

ScopeOnly a few studies analyzed the role of allium vegetables with reference to head and neck cancers (HNC), with mixed results. We investigated the potential favorable role of garlic and onion within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.Methods and resultsWe analyzed pooled individual‐level data from eight case‐control studies, including 4590 cases and 7082 controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between garlic and onion intakes and HNC risk. Compared with no or low garlic use, the ORs of HNC were 0.95 (95% CI 0.71–1.27) for intermediate and 0.74 (95% CI 0.55–0.99) for high garlic use (p for trend = 0.02). The ORs of HNC for increasing categories of onion intake were 0.91 (95% CI 0.68–1.21) for >1 to ≤3 portions per week, and 0.83 (95% CI 0.60–1.13) for >3 portions per week (p for trend = 0.02), as compared to <1 portion per week. We found an inverse association between high onion intake and laryngeal cancer risk (OR = 0.69; 95% CI 0.54–0.88), but no significant association for other subsites.ConclusionThe results of this pooled‐analysis support a possible moderate inverse association between garlic and onion intake and HNC risk.
B1 and T1 mapping of the breast with a reference tissue method
Authors: Pineda Federico D. , Medved Milica , Fan Xiaobing , Karczmar Gregory S. 
Published: May 2015

PurposeTo develop a method for mapping the B1 field using a reference signal from a tissue with known T1.MethodsFlip angle correction factors were calculated in a region with a known “gold standard” T1; by comparing T1 values from a variable flip angle (VFA) sequence to the “gold standard” and correcting the value of the Ernst angle. The resulting partial B1 map was interpolated for all other regions. In the breast, fat is an ideal reference tissue because its T1 is spatially homogeneous and interpatient variability is low. This method was tested with scans of phantoms and patients (n = 4) on a 3T magnet. The performance of the method was evaluated by comparing the results of VFA T1 mapping with and without B1 correction to inversion recovery (IR) T1 maps.ResultsPhantom data determined that a linear inverse distance weighted interpolation accurately recovered the full B1 map. Use of interpolated maps to correct the VFA data in vivo, reduced the average difference in the T1 of parenchyma between VFA and IR results from 58% to 8%.ConclusionThis proof‐of‐principle study showed that it is possible to recover a full and accurate map of the B1 field in the breast by using a reference tissue (fat) with an accurately measured T1. Magn Reson Med 75:1565–1573, 2016. © 2015 Wiley Periodicals, Inc.
Are ECG monitoring recommendations before prescription of QT‐prolonging drugs applied in daily practice? The example of haloperidol
Authors: Warnier Miriam Jacoba , Rutten Frans Hendrik , Souverein Patrick Cyriel , de Boer Anthonius , Hoes Arno Wilhelmus , De Bruin Marie Louise 
Published: May 2015

AbstractPurposeMonitoring of the QT duration by electrocardiography (ECG) prior to treatment is frequently recommended in the label of QT‐prolonging drugs. It is, however, unknown how often general practitioners in daily clinical practice are adhering to these risk‐minimization measures. We assessed the frequency of ECG measurements in patients where haloperidol was initiated in primary care.MethodsPatients (≥18 years) with a first prescription of haloperidol in the UK Clinical Practice Research Datalink (2009–2013) were included. The proportion of ECGs made was determined in two blocks of 4 weeks: during the exposure period when haloperidol was initiated, and during the control period, 1 year before. Conditional logistic regression analysis was applied to calculate the relative risk of having an ECG in the exposure period compared with the control period. Subgroup analyses were performed to assess the proportion of ECG measurements in patients with one or more additional risk factors for QT prolongation.ResultsIn total, 3420 patients were prescribed haloperidol during the exposure period, and 1.8% of them had an ECG at treatment initiation, compared with 0.8% during the control period (relative risk [RR] 2.4 [1.5–3.8]). Of the patients with additional risk factors for QT prolongation, 1.9% of the patients had an ECG at initiation of the prescription, compared with 1.0% during the control period (RR 2.1 [1.2–3.5]).ConclusionsCompliance with recommendations to perform an electrocardiogram when starting a new QT‐prolonging drug is extremely low, when haloperidol is taken as an example. Copyright © 2015 John Wiley & Sons, Ltd.
Standardisation of the FAERS database: a systematic approach to manually recoding drug name variants
Authors: Wong Carmen K. , Ho Samuel S. , Saini Bandana , Hibbs David E. , Fois Romano A. 
Published: May 2015

AbstractPurposeThe US Food and Drug Administration Adverse Event Reporting System (FAERS), one of the world's largest spontaneous reporting systems, is difficult to use because of report duplication and a lack of standardisation in the recording of drug names. Unresolved data quality issues may distort statistical analyses, rendering the results difficult to interpret when detecting and monitoring adverse effects of pharmaceutical products. The aim of this study was to develop and implement a data cleaning protocol to identify and resolve drug nomenclature issues. The key ‘data treatment’ plan involved standardising drug names held in the FAERS database.MethodsFour million five hundred and six thousand five hundred and seventy‐seven. Individual Safety Reports submitted to the FAERS between 1 January 2003 and 31 August 2012 were included for this study. OpenRefine was used to standardise drug name variants in the database such that they were consistent with international non‐proprietary nomenclature defined by the World Health Organisation Anatomical Therapeutic Chemical classification. Drug variants where generic constituents could not be confidently determined, undecipherable drug names and non‐medicinal products were retained verbatim.ResultsAfter the standardisation process, more than 16 611 916 drug entries were cleaned to their relevant international non‐proprietary name. The cleaned drug table comprised 71 858 drug name variants and includes both standardised and original terms. Ninety‐nine per cent of drug names was standardised using this method.ConclusionsThe millions of reports enclosed in the FAERS contain valuable information that is of interest to pharmacovigilance, toxicology and post‐marketing surveillance researchers. With the standardisation of the drug nomenclature, the database can be better utilised by research groups around the world. Copyright © 2015 John Wiley & Sons, Ltd.