bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications
Authors: Czajkowsky Daniel M. , Andersen Jan Terje , Fuchs Anja , Wilson Timothy J. , Mekhaiel David , Colonna Marco , He Jianfeng , Shao Zhifeng , Mitchell Daniel A. , Wu Gang , Dell Anne , Haslam Stuart , Lloyd Katy A. , Moore Shona C. , Sandlie Inger , Blundell Patricia A. , Pleass Richard J. 
Published: April 2015

AbstractThe remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated hexameric-Fc (hexa-Fc), a ~20 nm oligomeric Fc-based scaffold that we here show binds low-affinity inhibitory receptors (FcRL5, FcγRIIb and DC-SIGN) with high avidity and specificity, whilst eliminating significant clinical limitations of monomeric Fc-fusions for vaccine and/or cancer therapies, in particular their poor ability to activate complement. Mass spectroscopy of hexa-Fc reveals high-mannose, low-sialic acid content, suggesting that interactions with these receptors are influenced by the mannose-containing Fc. Molecular dynamics (MD) simulations provides insight into the mechanisms of hexa-Fc interaction with these receptors and reveals an unexpected orientation of high-mannose glycans on the human Fc that provides greater accessibility to potential binding partners. Finally, we show that this biosynthetic nanoparticle can be engineered to enhance interactions with the human neonatal Fc receptor (FcRn) without loss of the oligomeric structure, a crucial modification for these molecules in therapy and/or vaccine strategies where a long plasma half-life is critical.
Fluorescence-Activated Cell Sorting Analysis of Heterotypic Cell-in-Cell Structures
Authors: He Meifang , Huang Hongyan , Wang Manna , Chen Ang , Ning Xiangkai , Yu Kaitao , Li Qihong , Li Wen , Ma Li , Chen Zhaolie , Wang Xiaoning , Sun Qiang 
Published: April 2015

AbstractCell-in-cell structures (CICs), characterized by the presence of one or more viable cells inside another one, were recently found important player in development, immune homeostasis and tumorigenesis etc. Incompatible with ever-increasing interests on this unique phenomenon, reliable methods available for high throughput quantification and systemic investigation are lacking. Here, we report a flow cytometry-based method for rapid analysis and sorting of heterotypic CICs formed between lymphocytes and tumor cells. In this method, cells were labeled with fluorescent dyes for fluorescence-activated cell sorting (FACS) by flow cytometry, conditions for reducing cell doublets were optimized such that high purity (>95%) of CICs could be achieved. By taking advantage of this method, we analyzed CICs formation between different cell pairs and found that factors from both internalized effector cells and engulfing target cells affect heterotypic CICs formation. Thus, flow cytometry-based FACS analysis would serve as a high throughput method to promote systemic researches on CICs.
Tunable quantum interference in a 3D integrated circuit
Authors: Chaboyer Zachary , Meany Thomas , Helt L. G. , Withford Michael J. , Steel M. J. 
Published: April 2015

AbstractIntegrated photonics promises solutions to questions of stability, complexity and size in quantum optics. Advances in tunable and non-planar integrated platforms, such as laser-inscribed photonics, continue to bring the realisation of quantum advantages in computation and metrology ever closer, perhaps most easily seen in multi-path interferometry. Here we demonstrate control of two-photon interference in a chip-scale 3D multi-path interferometer, showing a reduced periodicity and enhanced visibility compared to single photon measurements. Observed non-classical visibilities are widely tunable and explained well by theoretical predictions based on classical measurements. With these predictions we extract Fisher information approaching a theoretical maximum. Our results open a path to quantum enhanced phase measurements.
Nucleotide Sequence-Homology-Independent Breakdown of Transgenic Resistance by More Virulent Virus Strains and a Potential Solution
Authors: Kung Yi-Jung , You Bang-Jau , Raja Joseph A. J. , Chen Kuan-Chun , Huang Chiung-Huei , Bau Huey-Jiunn , Yang Ching-Fu , Huang Chung-Hao , Chang Chung-Ping , Yeh Shyi-Dong 
Published: April 2015

AbstractControlling plant viruses by genetic engineering, including the globally important Papaya ringspot virus (PRSV), mainly involves coat protein (CP) gene mediated resistance via post-transcriptional gene silencing (PTGS). However, the breakdown of single- or double-virus resistance in CP-gene-transgenic papaya by more virulent PRSV strains has been noted in repeated field trials. Recombination analysis revealed that the gene silencing suppressor HC-Pro or CP of the virulent PRSV strain 5-19 is responsible for overcoming CP-transgenic resistance in a sequence-homology-independent manner. Transient expression assays using agro-infiltration in Nicotiana benthamiana plants indicated that 5-19 HC-Pro exhibits stronger PTGS suppression than the transgene donor strain. To disarm the suppressor from the virulent strain, transgenic papaya lines were generated carrying untranslatable 5-19 HC-Pro, which conferred complete resistance to 5-19 and other geographic PRSV strains. Our study suggested the potential risk of the emergence of more virulent virus strains, spurred by the deployment of CP-gene-transgenic crops and provides a strategy to combat such strains.
FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis
Authors: Sun Liang , Hu Caiyou , Zheng Chenguang , Qian Yu , Liang Qinghua , Lv Zeping , Huang Zezhi , Qi KeYan , Gong Huan , Zhang Zheng , Huang Jin , Zhou Qin , Yang Ze 
Published: April 2015

AbstractForkhead box class O (FOXO) transcription factors play a crucial role in longevity across species. Several polymorphisms in FOXO3 were previously reported to be associated with human longevity. However, only one Chinese replication study has been performed so far. To verify the role of FOXO3 in southern Chinese in the Red River Basin, a community-based case-control study was conducted and seven polymorphisms were genotyped in 1336 participants, followed by a meta-analysis of eight case-control studies that included 5327 longevity cases and 4608 controls. In our case-control study, we found rs2802288*A and rs2802292*G were beneficial to longevity after Bonferroni correction (pallele = 0.005, OR = 1.266; pallele = 0.026, OR = 1.207). In addition, in the longevity group, carriers with rs2802288*A and rs2802292*G presented reduced HbA1c (p = 0.001) and homozygotes of rs2802292*GG presented improved HOMA–IR (p = 0.014). The meta-analysis further revealed the overall contribution of rs2802288*A and rs2802292*G to longevity. However, our stratified analysis revealed that rs2802292*G might act more strongly in Asians than Europeans, for enhancement of longevity. In conclusion, our study provides convincing evidence for a significant association between the rs2802288*A and rs2802292*G gene variants in FOXO3 and human longevity and adds the Southern Chinese in the Red River Basin to the growing number of human replication populations.
Soybean β-conglycinin improves carbohydrate and lipid metabolism in Wistar rats
Authors: Inoue Nao , Fujiwara Yuka , Kato Masaki , Funayama Asuwa , Ogawa Nozomi , Tachibana Nobuhiko , Kohno Mitsutaka , Ikeda Ikuo 
Published: April 2015

Abstract
The effects of dietary soybean β-conglycinin on lipid metabolism and energy consumption were studied in Wistar adult rats. Rats were fed, a diet containing casein (control group) or β-conglycinin (β-conglycinin group), for 4 weeks. Carbohydrate consumption was higher and fat consumption was lower in the β-conglycinin group than in the control group, whereas the total energy consumption was the same between the two groups. Serum adiponectin was higher in the β-conglycinin group than in the control group. Serum triacylglycerol levels in the β-conglycinin group were significantly lower than those in the control group. The secretion rate of triacylglycerols from the liver after the administration of tyloxapol, an inhibitor of lipolysis, was significantly lower in the β-conglycinin group than in the control group. These results suggest the possibility that β-conglycinin exerts hypolipidemic effects through an acceleration in carbohydrate consumption associated with an increase in adiponectin in rats.
Collective efficacy at the Rugby World Cup 2015 – The role of imagery and observation
Authors: Shearer David A. 
Published: April 2015

AbstractThe Rugby World Cup in 2015 will present each competing team with unique psychological challenges not usually encountered in normal international fixtures. In the “pressure‐pot” environment of the tournament, teams that have the strongest sense of collective efficacy will most likely perform to their best and respond positively to the outside stressors (e.g., media interest, public expectations). In this review, the importance of collective efficacy to team performance at the World Cup in terms of team resiliency and minimising process losses is discussed. In addition, the relationship between collective efficacy and other psychological factors such as team cohesion is highlighted. From a practical perspective, an introduction to interventions to develop collective efficacy is provided. In particular, the neuroscience evidence for the use of imagery and observation interventions to improve individual collective efficacy perceptions is highlighted. It is emphasised how these interventions are particularly suited to international teams who compete together sporadically. Finally, specific recommendations are made such that practitioners might be able to implement these strategies with their teams before the World Cup.
Quantification of Habitat and Community Relationships among Nearshore Temperate Fishes Through Analysis of Drop Camera Video
Authors: Easton Ryan R. , Heppell Selina S. , Hannah Robert W. 
Published: April 2015

Abstract
Temperate nearshore reefs along the Pacific coast of North America are highly valuable to commercial and recreational fisheries yet comprise a small fraction of the seabed. Monitoring fisheries resources in this region is difficult; high-relief structural complexity and adverse sea conditions have led to a paucity of information on temperate reef species assemblage patterns. Reliable, inexpensive tools and methods for monitoring are needed, as many traditional tools are both logistically complicated and expensive, limiting the frequency of their implementation over a large scale. Video drop cameras of varying designs have previously been employed to estimate fish abundance and distribution. We surveyed a nearshore rocky reef off the northern Oregon coast with a video lander (a video camera mounted on a landing platform so it can be dropped to the seafloor) over the spring and winter of 2011. We designed a 272-point systematic grid to document the species assemblage and the distribution and habitat associations of the reef species, including two overfished rockfishes: Canary Rockfish Sebastes pinniger and Yelloweye Rockfish Sebastes ruberrimus. Species assemblages differed significantly across the reef by depth and by season for the outer part of the reef. Well-defined habitat associations existed for many species; Canary Rockfish were associated with complex moderate-relief habitat types such as large boulders and small boulders, while Yelloweye Rockfish were associated with high-relief habitats like vertical walls. Species associations were evaluated pairwise to identify nearshore complexes. We compared our site with five exploratory reef sites off the central Oregon coast and found that nearshore reefs differed from our site, while offshore reefs were more similar. Video landers provide a solution to the need for increased sampling of temperate reef systems that are subject to difficult conditions and can contribute to habitat mapping, fish abundance indices, and fish assemblage information for monitoring and management of fisheries resources.
Received October 18, 2014; accepted January 3, 2015
International strategic management hybrids in China
Authors: Jansson Hans , Söderman Sten 
Published: April 2015

Purpose– The purpose of this paper is to establish a comparative conceptual framework to analyze hybrids of western and Chinese strategic management types, where the foundation is an institutional strategic management theory.Design/methodology/approach– This framework is then applied to develop a research instrument that is used in a pilot study of 21 cases in China, primarily Swedish MNCs.Findings– In this study, a complex picture emerges of the various mixes of management types in international firms operating in China. The results demonstrate that the comparative institutional strategic management framework developed seems to work for studying such mixtures of management types.Research limitations/implications– The discussion is based on the assumption of two dominating management types in international firms in China. The authors have found different mixtures among the firms. Besides strategic management, the theory and instrument might also be useful for human resource management issues like recruitment and talent management.Practical implications– Practical implications include a potentially useful measurement tool for strategic management in international firms and for evaluating executives in existing and new positions. Moreover, a contribution is made to global management, since the framework is also useful for comparing strategic management types of international firms in and outside China.Originality/value– This paper contributes to this research in two ways. First, a comparative theory is specified to study the hybrids of strategic management types of international firms, especially for firms in China. Second, an instrument is developed for researching such management mixes and used on a pilot study of international firms operating in China.
State corporatism and business associations in China
Authors: Unger Jonathan , Chan Anita 
Published: April 2015

Purpose– All of the major market economies of East Asia have developed institutional arrangements through which business associations, labor unions, and other major types of associations maintain close relationships with the state. During the stage in which these were emerging economies, the state dominated this relationship in an arrangement known as “state corporatism.” But with democratization, Japan’s, Taiwan’s, and South Korea’s business associations and unions came more under the influence their members, and a new balance in relations with the state emerged in an arrangement known as “societal corporatism.” In China, which is still in transition from the status of an emerging economy, the state continues to dominate associations. The purpose of this paper is to explore the situation in China and to analyze whether the government is likely to maintain its dominance in future decades over powerful economic constituencies and their associations.Design/methodology/approach– The historical transition from state corporatism to societal corporatist practices in East Asia is discussed on the basis of available English-language literature. This forms the framework for an analysis of China, based largely upon on-site research and Chinese-language writings. The paper includes case studies of China’s two major business associations.Findings– The paper finds that China’s controls over business associations using state corporatist techniques are likely to persist in coming decades, due to the government’s vigilance in warding off any transition to members’ influence and societal corporatism.Practical implications– The influence of the state on businesses and unions and on business associations affects the operations of these vival economic institutions as well as the shaping of government policies.Originality/value– To understand relations between business associations and governments in East Asia, especially China, it is necessary to come to grips with the concept and practices of corporatism. This paper uses a comparative perspective to illuminate trends in the region’s capitalist countries and to cast new light on China.
Heuristics-in-use in industrial interfirm-collaborating clusters
Authors: Lai Wen-Hsiang , Woodside Arch G 
Published: April 2015

Purpose– The purpose of this paper is to help interfirm-collaborating cluster (ICC) executives examine the relevance of alternative decision rules in practical business contexts. Multi-party-implemented strategies and establishing multi-lateral collaborations are necessary actions for achieving success in new product development by small and medium enterprises (SMEs). This study explores interfirm decision-making heuristics relating to industrial ICCs.Design/methodology/approach– The study examines the relevancy to decision making in ICCs of heurstics such as “fast-and-frugal decision trees” (FFDTs) and “take-the-best” (TTB) to processing possibly influential decision-making cues. The study also examines simple heuristics versus the value of a “fully rational” approach to making decisions – calculating cue values, importance weights, multiplying values by weights, summing and selecting the option having the highest summed score. This study included interviewing executives of the pivotal firm in an ICC.Findings– This study reveals a decision-making solution for shortening the time and processes required in seeking new business collaboration partners in an ICC. This study not only develops a FFDT for six decision-making modules to quickly identify potential collaboration partners, but it also constructs a decision systems analysis (DSA) flowchart to effectively shorten the decision-making process.Research limitations/implications– This study is in accordance with the general type of industrial interfirm collaboration in Taiwan. The industrial interfirm collaboration could be further divided into the types of formal, semi-formal and informal industrial interfirm collaborations.Practical implications– This study argues that firms usually find it difficult to develop their own technology because of the high costs of research and development for SMEs. Therefore, firms need to collaborate with partners to maintain their competitive advantage. However, to collaborate, firms must learn to trust their collaboration partners, and the degree of collaboration also strongly depends on the degree to which they trust their collaboration partners.Originality/value– This study provides the efficient models of FFDT and DSA to quickly identify potential collaboration partners and to effectively shorten decision-making processes.
The relationship between organizational characteristics and membership of a biotechnology industry board-of-directors-network
Authors: Crispeels Thomas , Willems Jurgen , Brugman Paul 
Published: April 2015

Purpose
– The purpose of this study is to investigate the relationship between organizational characteristics and presence in a board-of-directors (BoD)-network, in the context of the biotechnology industry. Accessing and integrating external knowledge is key to an organization’s success within innovative industries. This can occur through inter-organizational networks such as the BoD-network.

Design/methodology/approach
– The authors apply a network analysis method (Robins and Alexander, 2004) and a logistic regression to a proprietary database of Belgian biotechnology organizations.

Findings
– The authors conclude that some organizational characteristics influence the presence of a biotechnology organization in the regional BoD-network. Academic spin-offs, start-ups and small companies are more likely to be part of the regional biotechnology BoD-network. The authors also observe that organizations involved in innovative activities are prominently present in the BoD-network. Interestingly, key actors like universities or academic hospitals are less present in the network.

Research limitations/implications
– The authors show that studying full networks and heterogeneous groups of organization leads to a better understanding of the causal mechanisms and dynamics of inter-organizational networks. To better understand the network dynamics in a context as complex as the biotechnology industry, multiple networks need to be studied simultaneously.

Practical implications
– The findings in this study allow for the development of policies addressing knowledge transfer, diffusion of management and governance practices, and the initiation and management of collaborative projects through the BoD-network. The authors observe a self-reinforcing dependency between innovative activities and BoD-network membership. This implies that policies aimed at stimulating innovation should also aim at increasing the target organizations’ presence in the BoD-network. Analyzing an organization’s innovative activities and position in the BoD-network allows for identifying those organizations that contribute most to the region’s knowledge transfer network and innovative capacity.

Originality/value
– The authors combine two different research streams and are the first to study the complete BoD-network of a biotechnology industry agglomeration.
Is this network for you or for me? The pursuit of self and collective interests in a strategic network
Authors: Munksgaard Kristin Balslev 
Published: April 2015

Purpose– This paper aims to contribute by providing a more comprehensive understanding of the inter-relatedness of business goals among firms in strategic networks by exploring the following research question: How do different business goals coexist in networks? When joining a strategic network, firms are likely to pursue goals of self–interest, as well as those of collective interests. Goal formulation and joint network activities provide vital information toward investigating how firms utilize their network for the purpose of accessing, capturing and integrating the efforts of others to achieve their own goals.Design/methodology/approach– The empirical basis is a case study of a strategic network of food producers in Denmark. Twenty qualitative face-to-face interviews with strategic network member firms constitute the empirical data that are analyzed using the software Leximancer.Findings– This research combines the goal formulation and business of a single firm with the collective and joint effort of a strategic network to help broaden our knowledge of how different goals and strategies coexist in networks. A typology of business goals in networks is developed. Appellations of “Achievers”, “Wishers” and “Harvesters” help to characterize the different types of goal formulation strategies in these networks.Research limitations/implications– It is not appropriate to make statistical generalizations based upon this study.Originality/value– This research aims to contribute by providing a more comprehensive understanding of the inter-relatedness of formulated goals, choices and interactions among firms in a strategic network context.