bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eribulin Monotherapy in Patients Aged 70 Years and Older With Metastatic Breast Cancer
Authors: Muss Hyman , Cortes Javier , Vahdat Linda T. , Cardoso Fatima , Twelves Chris , Wanders Jantien , Dutcus Corina E. , Yang Jay , Seegobin Seth , O'Shaughnessy Joyce 
Published: March 2014

Abstract

Purpose.
Following the demonstrated efficacy and safety of eribulin mesylate in heavily pretreated patients with metastatic breast cancer, an exploratory analysis was performed to investigate the effect of age in these patients.

Methods.
Data were pooled from two single-arm phase II studies and one open-label randomized phase III study in which patients received eribulin mesylate at 1.4 mg/m2 as 2- to 5-minute intravenous infusions on days 1 and 8 of a 21-day cycle. The effect of age on median overall survival (OS), progression-free survival (PFS), overall response rate (ORR), clinical benefit rate (CBR), and incidence of adverse events (AEs) was calculated for four age groups (&lt;50 years, 50–59 years, 60–69 years, ≥70 years).

Results.
Overall, 827 patients were included in the analysis (&lt;50 years, n = 253; 50–59 years, n = 289; 60–69 years, n = 206; ≥70 years, n = 79). Age had no significant impact on OS (11.8 months, 12.3 months, 11.7 months, and 12.5 months, respectively; p = .82), PFS (3.5 months, 2.9 months, 3.8 months, and 4.0 months, respectively; p = .42), ORR (12.7%, 12.5%, 6.3%, and 10.1%, respectively), or CBR (20.2%, 20.8%, 20.4%, and 21.5%, respectively). Although some AEs had higher incidence in either the youngest or the oldest subgroup, there was no overall effect of age on the incidence of AEs (including neuropathy, neutropenia, and leukopenia).

Conclusion.
Eribulin monotherapy in these selected older patients with good baseline performance status led to OS, PFS, ORR, CBR, and tolerability similar to those of younger patients with metastatic breast cancer. The benefits and risks of eribulin appear to be similar across age groups.
Mitomycin C and High-Dose 5-Fluorouracil With Folinic Acid as a Therapeutic Option for Heavily Pretreated Patients With Metastatic Colorectal Cancer: Prospective Phase II Trial
Authors: Stec Rafał , Bodnar Lubomir , Smoter Marta , Korniluk Jan , Kuchar Agata , Młot Beata , Szczylik Cezary 
Published: March 2014

Abstract

Author Summary

Background.
Standard treatment for patients with unresectable colorectal cancer metastases includes chemotherapy regimens based on irinotecan, oxaliplatin, fluoropyrimidines, anti-vascular endothelial growth factor therapy, and anti-EGFR. Additional therapeutic options are needed for patients with good performance status who have disease progression during or after standard therapies.

Methods.
A nonrandomized phase II study was modeled as a two-stage Chen design. Eligible patients had a diagnosis of metastatic colorectal cancer (mCRC) with progression after prior cytotoxic regimens based on oxaliplatin and irinotecan. Treatment consisted of mitomycin C in combination with high-dose 5-fluorouracil (5-FU) and folinic acid (the MLF regimen; mitomycin C as an intravenous bolus of 6 mg/m2 i.v. on days 1 and 22 every 7 weeks; folinic acid at 250 mg/m2 in combination with 5-FU at 2,600 mg/m2 as a continuous intravenous infusion (24 hours) weekly for 6 of every 7 weeks.

Results.
The median age of the 74 eligible patients was 62 years (range: 47–79 years). In these heavily pretreated patients with mCRC, the MLF regimen was the fourth or fifth line in more than 60% of the patients. Two patients (3.2%) achieved a partial response, and 33 (53.2%) achieved a best response of stable disease, defined as neither sufficient shrinkage to qualify for partial response nor sufficient increase to qualify for progressive disease. Median progression-free survival was 4.9 months. The median overall survival was 9.7 months. The most common nonhematologic side effects included mucositis (24.4% for all grades, and 9.5% with grade 3/4), diarrhea (15.0% for all grades, 13.6% with grade 3/4), fatigue (44.7% for all grades, 13.6% with grade 3/4), nausea (12.3% for all grades, 6.8% with grade 3/4), and peripheral neuropathy (17.6% for all grades, 2.7% with grade 3/4). Among the most frequent hematological toxicities were neutropenia (27.1% for all grades, 14.9% with grade 3/4), thrombocytopenia (18.9% for all grades, 8.1% with grade 3/4), and anemia (13.6% for all grades, 4.1% with grade 3/4). Dose reductions due to adverse events were necessary in 29 of 74 patients (37.6%), and discontinuation of therapy due to toxicity was necessary for 14 of 74 patients (18.2%).

Conclusion.
Our study shows the MLF regimen can be administered safely to patients with heavily pretreated mCRC. Median progression-free and overall survival compares favorably with other options used or approved in this setting. A randomized trial in this setting should be considered.
Hydrogenation of chloronitrobenzenes over Pd and Pt catalysts supported on cationic resins
Authors: Králik Milan , Vallušová Zuzana , Major Peter , Takáčová Adriana , Hronec Milan , Gašparovičová Dana 
Published: March 2014

AbstractLiquid phase hydrogenation of chloronitrobenzene isomers (x-CNB x = 2, 3, 4) to the corresponding chloroanilines (x-CAN) at mild reaction conditions (0.6 MPa, 25°C, diethyl ether-methanol as solvents) over palladium and platinum catalysts containing 1 mass % of metal on trimethylammonium functionalized poly{styrene-co-divinylbenzene} (Dowex-D) was studied. The average selectivities to x-CAN over Pd/D-Cl and Pd/D-OH catalysts were 72 % and 42 %, respectively, at the x-CNB conversion of about 80 %. The average selectivities of 81 % and 84 % were achieved using Pt/D-Cl and Pt/D-OH, respectively, at the x-CNB conversion of approximately 90 %, whereas the average starting reaction rates were 1.2 × 10−3 mol g−1 s−1 and 2.6 × 10−3 mol g−1 s−1 (hydrogen consumption rate per mass of platinum), respectively. Under similar reaction conditions, using palladium catalysts supported on a resin with anionic groups anchored to polymeric chains at the average reaction rate equal to 3.8 × 10−3 mol g−1 s−1 (hydrogen consumption rate per mass of palladium), the selectivities from 85 % (2-CAN and 3-CAN) to 95 % (4-CAN) were achieved (Kratky et al., 2002).
Effect of apple pomace powder addition on farinographic properties of wheat dough and biscuits quality
Authors: Kohajdová Zlatica , Karovičová Jolana , Magala Michal , Kuchtová Veronika 
Published: March 2014

AbstractIn the present study, dietary fibre rich powders obtained from two apple cultivars (Gala, Golden Delicious) were analysed for their chemical composition and functional properties. Apple powders contained more than 50 mass % of total dietary fibre and showed high values of hydration properties such as water holding (11.73–18.34 g g−1), water retention (11.31–11.68 g g−1) and swelling capacity (7.19–8.03 cm3 g−1). Incorporation of apple pomace powders (5 mass %, 10 mass %, and 15 mass %) to wheat dough resulted in a significant increase of water absorption (58.60–71.80 mass %), dough development time (from 3.43 min to 5.53 min) and dough stability (from 9.40 min to 10.90 min). The results also indicate that an addition of higher amounts (10 mass % and 15 mass %) of apple pomace powders negatively affects the volume, thickness, width, and spread ratio of biscuits and reduces their overall acceptance. Sensory analysis also showed that no significant differences between the control biscuits and biscuits containing 5 mass % of apple pomace powder from cultivar Gala were found.
Effect of temperature on the equilibrium and kinetics of galactose, glucose, and lactose adsorption on a cation exchanger
Authors: Wiśniewski Łukasz , Vaňková Katarína , Ačai Pavel , Polakovič Milan 
Published: March 2014

AbstractGalacto-oligosaccharides are typically produced by an enzymatic reaction when the post-reaction mixture contains considerable amounts of lactose and glucose and a smaller amount of galactose. In order to develop a process of chromatographic removal of saccharide impurities, adsorption equilibria and kinetics of these di- and monosaccharides were investigated for Diaion UBK 530, an industrialgrade strong cation-exchanger in the Na+ form. Frontal chromatographic experiments were carried out in the temperature range of 30–70°C and a broad interval of saccharide concentrations up to 350 g L−1. Breakthrough curves were described using the equilibrium-dispersive model with the linear adsorption isotherm. Both the distribution and the axial dispersion coefficient values depended on the saccharide molecule type and size. No significant effect of temperature or concentration on the distribution coefficient was observed. The apparent dispersion coefficients of all saccharides exhibited some decrease with the temperature, which was caused by the decrease of the intraparticle mass transfer resistance. An analysis showed that both the intraparticle mass transfer and the axial dispersion had a significant influence on the front dispersion.
Recent advances in miniaturized optical gyroscopes
Authors: Dell’Olio F. , Tatoli T. , Ciminelli C. , Armenise M. N. 
Published: March 2014

Low-cost chip-scale optoelectronic gyroscopes having a resolution ≤ 10°/h and a good reliability also in harsh environments could have a strong impact on the medium/high performance gyro market, which is currently dominated by well-established bulk optical angular velocity sensors. The R&D activity aiming at the demonstration of those miniaturized sensors is crucial for aerospace/defense industry, and thus it is attracting an increasing research effort and notably funds.
In this paper the recent technological advances on the compact optoelectronic gyroscopes with low weight and high energy saving are reviewed. Attention is paid to both the so-called gyroscope-on-a-chip, which is a novel sensor, at the infantile stage, whose optical components are monolithically integrated on a single indium phosphide chip, and to a new ultra-high Q ring resonator for gyro applications with a configuration including a 1D photonic crystal in the resonant path. The emerging field of the gyros based on passive ring cavities, which have already shown performance comparable with that of optical fiber gyros, is also discussed.
Plasma Fibrinogen Along with Patient-reported Outcome Measures Enhances Management of Polymyalgia Rheumatica: A Prospective Study
Authors: McCarthy Eoghan M. , MacMullan Paul A. , Al-Mudhaffer Shibeb , Madigan Anne , Donnelly Suzanne , McCarthy Conor J. , Molloy Eamonn S. , Kenny Dermot , McCarthy Geraldine M. 
Published: April 2014

Objective.We sought to prospectively examine the responsiveness of a number of patient-reported outcome (PRO) measures in polymyalgia rheumatica (PMR), as well as their relationship to the biomarkers erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and plasma fibrinogen.Methods.Sixty patients with PMR were divided into active (n = 25) or inactive (n = 35) disease groups based on symptoms; physician assessment; and the biomarkers ESR, CRP, and plasma fibrinogen. Groups underwent assessment at baseline and 6 weeks. Disease activity measures and relevant PRO measures were recorded. Measures of responsiveness were compared for all PRO and biomarkers.Results.Visual analog scale disease activity (VASDA) and VAS quality of life (VASQOL) are more responsive to change in disease activity than VAS pain, morning stiffness, Health Assessment Questionnaire (HAQ), and PMR-activity score (AS). Analysis of PMR-AS versus VASDA, VASQOL, and HAQ showed correlation coefficients of 0.87 (p < 0.001), 0.80 (p < 0.001), and 0.68 (p < 0.001), respectively. Receiver-operating curve (ROC) analysis revealed VASDA to be more specific than either HAQ (0.95 vs 0.85; p < 0.001) or VASQOL (0.95 vs 0.93; p < 0.001) for the detection of response to treatment in active PMR. Overall, fibrinogen showed superior correlation coefficients with the various PRO than either of the standard biomarkers ESR or CRP. In addition, standardized response means for fibrinogen, ESR, and CRP were 1.63, 1.2, and 1.05, respectively, indicating that plasma fibrinogen was the most responsive biomarker for assessment of change in disease activity.Conclusion.VASDA and VASQOL are the most responsive PRO to changes in disease activity in PMR. In addition, plasma fibrinogen demonstrated greater responsiveness to changes in disease activity and superior correlation with the various PRO measures recorded than did the standard biomarkers ESR and CRP.
Aux sources de la dépendance : l'éternel retour des commencements
Authors: Missonnier Sylvain 
Published: March 2014

L’humain se caractérise toute sa vie durant par sa dépendance. Pour le clinicien, il ne s’agit donc point de savoir si tel ou tel sujet est dépendant ou non mais bien d’envisager la spécificité psycho(patho)logique de sa dépendance et de son devenir à travers les multiples épreuves de différenciation puis de séparation. À partir des leçons de la clinique périnatale, cette contribution souhaite mettre en exergue l’importance trop souvent méconnue du temps refoulé d’avant la séparation : le temps de la différenciation, de l’impuissance originelle et de la dépendance absolue. La vertu de ce détour est de favoriser une psycho(patho)logie psychanalytique de la dépendance qui ne scotomise pas la situation anthropologique fondamentale, où la fragilité inhérente à la dépendance de notre néoténie s’impose comme l’axe majeur potentiel de notre créativité humaine, mais aussi, de certains de ses naufrages.
L'alcool comme pseudo-objet transitionnel
Authors: Ducarre Catherine 
Published: March 2014

Le sujet dépendant de l’alcool tente non seulement de surmonter une dépendance à un objet insuffisamment introjecté mais cherche aussi en même temps à noyer une excitation interne intolérable, faute d’un refoulement suffisamment opérant. À travers deux illustrations cliniques, cet article pointe le défaut de transitionalité chez le patient alcoolique en même temps que la fonction complexe de l’addiction à l’alcool : pseudo-objet transitionnel qui tente de combler un vide et à la fois de neutraliser un objet interne trop envahissant et excitant.
De la contention à la contenance : usage de la psychothérapie en prison
Authors: Sergent Maud 
Published: March 2014

De la répétition des passages à l’acte à celle des incarcérations, comment comprendre les enjeux psychiques à l’œuvre chez un patient qui semble s’étayer avec force sur l’aspect matériel de la réalité extérieure ? Entre dépendance et soumission, comment le soin peut-il s’envisager en milieu carcéral ? C’est au détour d’un cas clinique qu’il s’agira d’aborder ces questionnements.
Le jeu vidéo, un objet de soin ?
Authors: Le Bihan Éva 
Published: March 2014

La dépendance a de multiples visages mais n’a pas d’âge... De plus en plus d’adolescents en situation d’impasse sont accueillis au sein des établissements de soin. Leur souffrance s’exprime par des conduites d’évitement, des déscolarisations, alors même que ce sont souvent de bons élèves, un enfermement au domicile, un repli sur eux-mêmes, une perte de repères et potentiellement un risque de certaines formes de dépendance. Chez ces jeunes, l’entrée dans la puberté et l’adolescence semble raviver de profondes angoisses plus ou moins masquées durant l’enfance. Ils sont en situation d’impasse. Dans l’accompagnement d’adolescents qui tendent à se couper du monde et parfois d’eux-mêmes, enlisés dans leurs peurs et l’immobilisme qui en découle, l’utilisation d’un jeu vidéo, bien choisi et testé, peut parfois aider à installer une aire de rencontre et d’échange avec le soignant, préalable indispensable à toute évolution accompagnée. La médiation ludique ne pourrait-elle pas permettre de réinscrire, progressivement, un jeune en difficulté dans une dynamique relationnelle ? À partir d’un cas clinique, celui de César, l’auteur tente de retrouver le fil du processus thérapeutique tel qu’il s’est déroulé, d’en tirer quelques leçons d’expérience et de proposer un aperçu plus global des éléments constitutifs d’une dynamique psycholudique qui puisse être porteuse de réassurance pour les jeunes patients.
La dépendance au virtuel en question
Authors: Huerre Patrice , Belamich Garance 
Published: March 2014

Après avoir rappelé la place des nouvelles technologies dans notre société, les auteurs proposent une réflexion autour de la question de la dépendance au virtuel. Si son utilisation vient répondre directement aux problématiques adolescentes, quelle peut être l’origine d’un « mésusage » des écrans ? Qu’est-ce qui est précisément recherché dans l’utilisation de ces « mondes virtuels » ? Quels sont les éléments de vulnérabilité pouvant conduire aux usages excessifs, et quelle peut être la fonction de cet abus au niveau de l’économie psychique ? Pour illustrer leur propos, les auteurs présentent ensuite le cas clinique d’un jeune patient hospitalisé où l’exploration de la nature de son lien aux jeux vidéo a permis un accès direct à des contenus inconscients réprimés et anxiogènes.
Des dépendances sexuelles à la sexualité addictive
Authors: Estellon Vincent 
Published: March 2014

Depuis quelques décennies, certains auteurs, à la suite de J. McDougall, se sont intéressés à une symptomatologie clinique contemporaine particulière désignée sous le terme de « sexualité addictive ». Au sein de cette configuration clinique marquée du sceau de la compulsion de répétition, le sujet, plutôt que de se risquer à éprouver des affects qui menacent l’intégrité narcissique déjà fragilisée, recherche avant tout l’épreuve de sensations corporelles. Quel objet se cache sous le masque de la série des corps anonymes ? Comment les larges ressources de la psychosexualité en viennent à se réduire à son expression la plus rudimentaire de décharge ? Quels liens peut-on opérer entre les sexualités dépendantes et les fonctionnements limites ? Sur la base de considérations théorico-cliniques, cet article apporte des éléments de réponses à ces questions.
Institutions politiques et réforme des retraites aux États-Unis et au Canada
Authors: Béland Daniel 
Published: March 2014

Mettant l’accent sur les facteurs institutionnels et les stratégies des acteurs politiques, l’article suivant analyse le changement institutionnel dans le domaine des politiques de retraite aux États-Unis et au Canada depuis le début des années 1980. En matière de politiques de retraite comme dans d’autres secteurs de l’action publique, il est approprié de comparer ces deux pays « libéraux » qui, tout en laissant un grand rôle au marché, possèdent des institutions politiques et des programmes sociaux bien distincts. L’article souligne à la fois le poids certain de ces différences institutionnelles et l’existence de stratégies de réforme communes dans les deux pays à l’étude. Axé sur l’analyse du versant public des systèmes de retraite tout en tenant compte de l’épargne et des pensions privées, l’article adopte une approche historique en contrastant trois périodes dans chaque pays : les années Reagan (1981-1989) et Mulroney (1984-1993), les années Clinton (1993-2001) et Chrétien (1993-2003), et les années George W. Bush (2001-2009) et Harper (2006-).
Quand techniciser c'est faire de la politique « sans le dire »
Authors: Dufournet Hélène 
Published: March 2014

L’article analyse les modalités de gestion du dossier des armes à sous-munitions par les fonctionnaires de la Division « maîtrise des armements » de l’état-major des Armées. Fermement opposés à l’interdiction de ces armes, les militaires français sont parvenus à construire une position qui justifie le maintien d’un statu quo sur la question. Cette position fait l’objet d’un large consensus entre militaires et diplomates, entre fonctionnaires et politiques. En se penchant sur les conditions de diffusion de cette qualification du problème dans le système politico-administratif français, l’article montre comment la technicisation du problème par les militaires correspond à un travail de « transcodage juridico-technique » qui doit son succès, non pas à une « activité de décision fictive » du politique, inhérente à un mode de « gestion technocratique », mais plutôt à la prise en compte des injonctions auxquelles le politique est soumis. Vu sous cet angle, le travail de technicisation mené par les services administratifs correspond moins à un travail de dépolitisation qu’à un travail d’a-politisation pour évacuer la dimension politique du dossier.
Estrutura, processo, função e forma no setor agrário do noroeste do Rio Grande do Sul
Authors: Gass Sidnei Luís Bohn , Verdum Roberto , Mantelli Jussara 
Published: March 2014

A integração e aplicação dos conceitos e métodos da Geografia, em muitos casos, apresentam significativa complexidade, em especial quando se utiliza referenciais que trazem um amplo grau de aprofundamento acadêmico. Em muitos casos, isto pode dificultar a compreensão de determinados acontecimentos dentro de um quadro mais amplo de análise, sobretudo, por necessitar da utilização de resgates históricos que auxiliem na definição dos cenários atuais, em que determinados segmentos da sociedade atuam. Neste artigo temos a finalidade de avaliar de que maneira ocorreu o avanço sobre a compreensão e aplicação do Código Florestal Brasileiro, Lei Federal nº 4.771, de 15 de setembro de 1965, revogado em 2012. De outro lado, como ocorreu o processo de uso e ocupação do território da Região Noroeste do Rio Grande do Sul, Brasil. Para tornar possível tal análise, tomamos por base o processo de colonização européia no Rio Grande do Sul, os fluxos migratórios, o desmatamento e a atividade agrícola, assim como, a degradação e a consciência ambiental adquiridas no período. As conexões necessárias para a compreensão dos dois cenários colocados: a) o processo de uso e ocupação do solo e b) o avanço do Código Florestal, serão buscadas através dos escritos de Milton Santos (1985), obra na qual o autor trata da estrutura, do processo, da função e da forma como categorias de análise do método geográfico. Através das discussões apresentadas pelo autor será possível identificar as diferentes temporalidades presentes e destoantes nos cenários em questão. As relações que se estabelecem entre: a estrutura, o processo, a função, a forma, as questões de uso e ocupação do solo e a compreensão e aplicação da legislação ambiental, partem do conceito de espaço. Este que constitui uma realidade objetiva e é um produto social em processo permanente de transformação. Uma vez que o espaço impõe sua própria realidade, fica evidente que há, ao menos, dois tempos distintos a serem considerados nas questões de análise regional: o tempo do processo de ocupação regional - que gera o enfrentamento dialético com a natureza sob o aspecto da sua ocupação - e que resultará em novas formas dotadas de rugosidades que contarão a história regional futura; o tempo político - representado pelas políticas públicas e pelas evoluções legais - que ocorrem em total descompasso com o desenvolvimento regional. Cabe aos pesquisadores acompanhar a aplicação das novas legislações e adaptações a elas, para possibilitar a continuidade das avaliações preliminares elaboradas no presente artigo.