bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management and outcomes of aortic dissection type B in late pregnancy: A retrospective case series
Authors: Wang Zhen , Yu Xuechen , Ding Shuai , Zhang Wei , Liang Chuan , Chen Huijun 
Published: July 2024

AbstractObjectivePregnancy complicated with type B aortic dissection is a rare but devastating condition. Guidelines for managing this condition are lacking. We present our observation and experiences in managing five pregnant women with complicated type B aortic dissection in the second or third trimesters, aiming to gain insights that can aid in proposing an appropriate management strategy.DesignA retrospective study.SettingZhongnan Hospital of Wuhan University.PopulationPregnant women with complicated type B aortic dissection.MethodsClinical data of five pregnant women with complicated type B aortic dissection admitted to Zhongnan Hospital of Wuhan University from January 2022 to June 2023 were collected. The clinical characteristics, treatment strategies, and corresponding maternal and infant outcomes were retrospectively analysed.Main Outcome MeasuresSurvival of mothers and foetuses.ResultsAll five study participants were diagnosed with complicated type B aortic dissection by computed tomography angiography (CTA). The range of gestational weeks at admission was 27 weeks + 3 days to 36 weeks + 6 days. The first patient, planning a caesarean section (C‐section) followed by thoracic endovascular aortic repair (TEVAR), died of aortic dissection rupture during C‐section. Her neonate was successfully rescued. In contrast, the remaining four patients who underwent TEVAR first survived. Among them, three patients underwent single‐stage aortic repair and delivery, while one patient received C‐section 31 days after TEVAR. Three preterm live births were recorded among these surviving mothers. Neonatal death occurred in one case with a gestational age of 29 weeks + 5 days, who had foetal distress before surgery. During the follow‐up period of up to 3 months, no maternal or infant death occurred. No device‐related or systemic complications were observed in the surviving mothers after discharge. Routine physical examinations of the four live births showed no abnormalities.ConclusionsFor pregnant women with thoracic back pain and high suspicion of aortic dissection, CTA should be conducted promptly to prevent missed or delayed diagnosis. Maternal survival should be prioritised over foetal outcome once diagnosed. TEVAR was demonstrated to be safe and feasible for such patients. For women with complicated type B aortic dissection in late pregnancy, TEVAR followed by C‐section may be a promising treatment strategy.
Focused deterrence, strategic management, and effective gun violence prevention
Authors: Braga Anthony A. , MacDonald John M. , Douglas Stephen , Wade Brian , Struhl Benjamin 
Published: July 2024

AbstractResearch SummaryThe evaluation literature suggests that focused deterrence strategies are effective in reducing gun violence. However, focused deterrence is notoriously difficult to implement and sustain. The history of focused deterrence implementation failure raises questions about its viability as a gun violence prevention strategy. Stockton, California, implemented focused deterrence three times during the past 25 years. In its most recent version, Stockton officials explicitly designed the strategy to be a permanent feature of the city's violence prevention portfolio. Although program caseloads diminished over the course of the COVID‐19 pandemic and the strategy faced leadership and resource challenges, Stockton's efforts prevented the program from being discontinued and, for those gang members who did receive treatment, delivered a robust gun violence prevention strategy. A quasi‐experimental evaluation shows that treated gang members were less likely to be shot and reduced their violent offending relative to similar untreated gang members. The focused deterrence impacts also appear to spill over to gang members who were socially connected to treated gang members. Although Stockton experienced an increase in homicides over the course of the COVID‐19 pandemic, the increase was not as steep as other comparable California cities.Policy ImplicationsFocused deterrence strategies can be effective responses to gun violence problems when implemented properly. A priori planning is essential when jurisdictions prepare to adopt focused deterrence. Strategic management actions, such as maintaining a robust network of partnering agencies, developing accountability structures and sustainability plans, and conducting upfront and ongoing problem analysis, are critical elements that must be in place for focused deterrence to be effective and sustainable.
Bisphosphonates show no association with preventing, slowing, or delaying radiographic changes and pain in hip osteoarthritis: A 4‐year study in female adults using data from the Osteoarthritis Initiative Study
Authors: Salis Zubeyir 
Published: July 2024

AbstractObjectiveThis study aimed to investigate the association of bisphosphonates with outcomes related to radiographic changes and pain in hip osteoarthritis (OA) over 4 years.MethodsThis study examined data from the Osteoarthritis Initiative (OAI), which included 4088 hips from 2057 participants. Bisphosphonate users were identified as those who reported usage at least three times, including at baseline and during the subsequent 1, 2, 3, and 4‐year follow‐up visits. Non‐users were participants who did not use bisphosphonates in the 5 years preceding the baseline and at subsequent follow‐up visits. Generalized estimating equations were performed to assess the association between bisphosphonate use and outcomes related to radiographic changes and pain in hip OA over a 4‐year follow‐up.ResultsThe analysis revealed no statistically significant difference between bisphosphonate users and non‐users concerning outcomes related to radiographic changes and pain in hip OA over 4 years. Specifically, the odds ratios for the incidence and transition of radiographic hip OA were 0.55 (95% Confidence Interval [CI]: 0.26 to 1.17) and 0.78 (95% CI: 0.47 to 1.28), respectively. Furthermore, the odds ratios for the development and resolution of frequent hip pain were 1.04 (95% CI: 0.76 to 1.42) and 0.99 (95% CI: 0.72 to 1.36), respectively.ConclusionThe findings from this longitudinal study do not suggest an association between bisphosphonate use and the prevention, slowing, or delay of development and transition of radiographic changes or pain in hip OA over a 4‐year follow‐up.
Changes in microbial community structure of bio‐fouled polyolefins over a year‐long seawater incubation in Hawai'i
Authors: Connors Elizabeth , Lebreton Laurent , Bowman Jeff S. , Royer Sarah‐Jeanne 
Published: July 2024

AbstractPlastic waste, especially positively buoyant polymers known as polyolefins, are a major component of floating debris in the marine environment. While plastic colonisation by marine microbes is well documented from environmental samples, the succession of marine microbial community structure over longer time scales (> > 1 month) and across different types and shapes of plastic debris is less certain. We analysed 16S rRNA and 18S rRNA amplicon gene sequences from biofilms on polyolefin debris floating in a flow‐through seawater tank in Hawai'i to assess differences in microbial succession across the plastic types of polypropylene (PP) and both high‐density polyethylene (HDPE) and low‐density polyethylene (LDPE) made of different plastic shapes (rod, film and cube) under the same environmental conditions for 1 year. Regardless of type or shape, all plastic debris were dominated by the eukaryotic diatom Nitzschia, and only plastic type was significantly important for bacterial community structure over time (p = 0.005). PE plastics had higher differential abundance when compared to PP for 20 bacterial and eight eukaryotic taxa, including the known plastic degrading bacterial taxon Hyphomonas (p = 0.01). Results from our study provide empirical evidence that plastic type may be more important for bacterial than eukaryotic microbial community succession on polyolefin pollution under similar conditions.
Paediatric postoperative acute kidney injury after non‐cardiac surgery: Protocol for a systematic review and meta‐analysis
Authors: Emami Arash , Sivertsson Ebba , Westerbergh Johan , Hultström Michael , Danielsson Johan , Frykholm Peter , Frithiof Robert 
Published: July 2024

AbstractBackgroundPaediatric acute kidney injury (AKI) is associated with significant adverse outcomes such as increased mortality, progression to chronic kidney disease and longer length of stay in hospital. Postoperative AKI is a common and recognized complication after surgery in adults. In the paediatric population, AKI postoperatively to cardiac surgery has been extensively studied. However, the incidence of postoperative AKI after non‐cardiac surgery is less clear. Therefore, we aim to assess the available literature on this topic.MethodsWe will conduct a systematic review of observational and randomized controlled trials assessing the incidence of paediatric postoperative AKI after non‐cardiac surgery. Pairs of reviewers will independently screen the literature and extract data and assess risk of bias from eligible studies. The databases Pubmed, Cochrane and Web of Sciences will be searched. We will conduct the review in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines and the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach. If sufficient homogeneity within the included trials we will conduct meta‐analyses.DiscussionThis systematic review aims to investigate the incidence of postoperative AKI in the paediatric non‐cardiac surgery population. The results of this review will provide a foundation for future research in the field of paediatric postoperative AKI.
The determined indeterminacy of white supremacy
Authors: Resnick Elana 
Published: July 2024

AbstractContemporary white supremacy often takes hold through strategies of racial disavowal. One strategy that political parties and regular citizens in Bulgaria use is what I call determined indeterminacy. Determined indeterminacy is a collective, institutionalized method of denying the ubiquitous systemic racism that undergirds social life. It allows people to naturalize white supremacy and render it adaptably persistent. This is the case especially in contexts of aspirational whiteness, such as Bulgaria, where whiteness is fraught and many people claim that their country has never been racial. Tracing Bulgaria's history of racial disavowal helps us understand how the local particularities of white supremacy naturalize, transform, and set in place long‐standing racial hierarchies.
Do we more often opt for conservative management of ovarian tumors after changing the Dutch national guideline on enlarged ovaries? A nationwide cohort study
Authors: Lems Esther , Koch Anna H. , Armbrust Sam , Leemans Jaklien C. , Bongers Marlies Y. , Leon‐Castillo Alicia , Lok Christianne A. R. , Geomini Peggy M. A. J. 
Published: July 2024

AbstractIntroductionIncreasing evidence shows that conservative management of ovarian tumors classified as benign, based on ultrasound assessment, is safe. Therefore, conservative management has been adopted as the preferred strategy for certain ovarian tumors assessed as benign in the Dutch national guideline on enlarged ovaries in 2013. The aim of this study was to examine whether implementation of this guideline has led to changes in the number of women/100 000 women undergoing surgery for an ovarian tumor in the Netherlands.Material and MethodsHistopathology reports were requested for all examinations of ovarian and fallopian tube specimens (including cyst enucleations) registered in Palga, the Dutch nationwide pathology databank, from 2011 (before guideline adaptation) and 2019 (after guideline adaptation). Reports on prophylactically removed adnexa, removal for other primary tumors (eg endometrial carcinoma), and for patients under 18 years of age, were excluded from the analysis. Interobserver agreement for the inclusion and classification of reports was assessed using Cohen's Kappa analysis.ResultsA total of 34 932 reports were retrieved, 13 917 of which were included in the analysis. In 2011 and 2019, respectively, 96.3/100 000 vs 68.8/100 000 women aged ≥18 underwent surgery for benign ovarian tumors, and 19.6/100 000 vs 18.3/100 000 for borderline and malignant tumors combined. The number of women/100 000 who had surgery for a benign ovarian tumor per 100 000 women declined by 28.5% (p < 0.001) between 2011 and 2019. The largest difference between 2011 and 2019 was observed in the number of women per 100 000 women who underwent surgery for a serous cystadenoma (−40.7%; 20.8/100 000 vs. 12.3/100 000), followed by endometrioma (−33.2%; 14.7/100 000 vs. 9.8/100 000), simple epithelial cyst (−57.3%; 8.4/100 000 vs. 3.6/100 000), and corpus luteum cyst (−57.0%; 4.0/100 000 vs. 1.7/100 000). Cohen's Kappa for the interobserver agreement was 0.96.ConclusionsThe number of women/100 000 undergoing surgery for a benign ovarian tumor has substantially decreased in the Netherlands when comparing data before and after implementation of the national guideline in 2013, while the number of women/100 000 undergoing surgery for a malignant or borderline tumor remained the same. These findings suggest successful implementation of the updated guideline, and a measurable effect on increased adoption of conservative management for benign‐looking ovarian tumors.
Expected and unexpected long‐term effects of values affirmation in school
Authors: Hadden Ian R. , Harris Peter R. , Easterbrook Matthew J. 
Published: July 2024

AbstractBackgroundAn earlier study in a school in England found that a series of brief values affirmation writing exercises, performed over the course of a school year by students aged 11–14, increased the mathematics attainment of students of low socioeconomic status (SES).AimsThis pre‐registered follow‐up of the original study aims to investigate the long‐term effects of values affirmation on low‐SES students' attainment.SampleThe sample consisted of all students in the analytical sample of the original study who remained at the school and for whom the necessary data were available, N = 409 (95 low‐SES).MethodsThe students' results in high‐stakes national standardized assessments at age 16, taken two to four years after the affirmation, were analysed.ResultsThe evidence did not support the pre‐registered hypotheses that values affirmation would raise the attainment of low‐SES students in mathematics and English. However, exploratory analyses suggested that for low‐SES students in two of the three‐year groups, the intervention increased Attainment 8, a broad policy‐relevant measure of academic attainment, and increased the attainment of boys in English (in particular English Literature) but reduced the corresponding attainment of girls.ConclusionsThe results suggest that the benefits of values affirmation can differ by student cohort and by school subject and that they might be time‐limited in some circumstances. This suggests a set of hypotheses that future research could test in order to advance understanding of when values affirmation is, and is not, successful for school students over a sustained period.
Mourning the Loss of the Ideal Self: Short‐Term Work with a Trans Patient Post‐Transition
Authors: Evans Marcus 
Published: July 2024

AbstractMany individuals who have been through transition struggle to obtain the necessary medical and psychological support. This paper explores the importance of psychological support for post‐transition individuals. In my experience, there is a subgroup of patients who struggle to come to terms with life post‐transition, particularly the losses involved. They remain stuck in the mourning process. There is a loss of fantasies regarding an ideal transition, and the gap between the hoped‐for transition outcomes and the post‐transition reality can be painfully large. In addition, issues that the transition was meant to address remain in some form for some people, and they may also be haunted by misgivings about how the transition occurred. This paper employs a heavily anonymised composite case to illustrate and elaborate on how these issues emerged and were dealt with in the context of a psychotherapeutic process. Working through issues that led to transition and grievances about perceived and actual failures in care from the past allowed the patient to mourn the loss of her pre‐transition image. The patient was able to come to terms with the reality of her transfer from male to trans‐female and her body and life post‐transition and to shift from a preoccupation with the past to move on with her life.
The atypical antipsychotics lurasidone and olanzapine exert contrasting effects on the gut microbiome and metabolic function of rats
Authors: Kamath Srinivas , Hunter Alexander , Collins Kate , Wignall Anthony , Joyce Paul 
Published: July 2024

AbstractBackground and PurposeAntipsychotics such as olanzapine are associated with significant metabolic dysfunction, attributed to gut microbiome dysbiosis. A recent notion that most psychotropics are detrimental to the gut microbiome has arisen from consistent findings of metabolic adverse effects. However, unlike olanzapine, the metabolic effects of lurasidone are conflicting. Thus, this study investigates the contrasting effects of olanzapine and lurasidone on the gut microbiome to explore the hypothesis of ‘gut neutrality’ for lurasidone exposure.Experimental ApproachUsing Sprague–Dawley rats, the effects of olanzapine and lurasidone on the gut microbiome were explored. Faecal and blood samples were collected weekly over a 21‐day period to analyse changes to the gut microbiome and related metabolic markers.Key ResultsLurasidone triggered no significant weight gain or metabolic alterations, instead positively modulating the gut microbiome through increases in mean operational taxonomical units (OTUs) and alpha diversity. This novel finding suggests an underlying mechanism for lurasidone's metabolic inertia. In contrast, olanzapine triggered a statistically significant decrease in mean OTUs, substantial compositional variation and a depletion in short‐chain fatty acid abundance. Microbiome depletion correlated with metabolic dysfunction, producing a 30% increase in weight gain, increased pro‐inflammatory cytokine expression, and increased blood glycaemic and triglyceride levels.Conclusion and ImplicationsOur results challenge the notion that all antipsychotics disrupt the gut microbiome similarly and highlights the potential benefits of gut‐neutral antipsychotics, such as lurasidone, in managing metabolic side effects. Further research is warranted to validate these findings in humans to guide personalised pharmacological treatment regimens for schizophrenia.
Practical applications of soil microbiota to improve ecosystem restoration: current knowledge and future directions
Authors: Peddle Shawn D. , Hodgson Riley J. , Borrett Ryan J. , Brachmann Stella , Davies Tarryn C. , Erickson Todd E. , Liddicoat Craig , Muñoz‐Rojas Miriam , Robinson Jake M. , Watson Carl D. , Krauss Siegfried L. , Breed Martin F. 
Published: July 2024

ABSTRACTSoil microbiota are important components of healthy ecosystems. Greater consideration of soil microbiota in the restoration of biodiverse, functional, and resilient ecosystems is required to address the twin global crises of biodiversity decline and climate change. In this review, we discuss available and emerging practical applications of soil microbiota into (i) restoration planning, (ii) direct interventions for shaping soil biodiversity, and (iii) strategies for monitoring and predicting restoration trajectories. We show how better planning of restoration activities to account for soil microbiota can help improve progress towards restoration targets. We show how planning to embed soil microbiota experiments into restoration projects will permit a more rigorous assessment of the effectiveness of different restoration methods, especially when complemented by statistical modelling approaches that capitalise on existing data sets to improve causal understandings and prioritise research strategies where appropriate. In addition to recovering belowground microbiota, restoration strategies that include soil microbiota can improve the resilience of whole ecosystems. Fundamentally, restoration planning should identify appropriate reference target ecosystem attributes and – from the perspective of soil microbiota – comprehensibly consider potential physical, chemical and biological influences on recovery. We identify that inoculating ecologically appropriate soil microbiota into degraded environments can support a range of restoration interventions (e.g. targeted, broad‐spectrum and cultured inoculations) with promising results. Such inoculations however are currently underutilised and knowledge gaps persist surrounding successful establishment in light of community dynamics, including priority effects and community coalescence. We show how the ecological trajectories of restoration sites can be assessed by characterising microbial diversity, composition, and functions in the soil. Ultimately, we highlight practical ways to apply the soil microbiota toolbox across the planning, intervention, and monitoring stages of ecosystem restoration and address persistent open questions at each stage. With continued collaborations between researchers and practitioners to address knowledge gaps, these approaches can improve current restoration practices and ecological outcomes.
Alveolar ridge bone changes in patients treated with the split‐crest technique with simultaneous implant placement: A retrospective longitudinal observational study
Authors: Garcez‐Filho João , Bianco Débora de Almeida , Barbisan de Souza André , de Oliveira Ricardo Puziol , Matarazzo Flávia , Araújo Maurício G. 
Published: July 2024

AbstractObjectivesTo investigate long‐term alveolar ridge bone changes in patients treated with the split‐crest technique (SCT) with simultaneous implant placement.Materials and MethodsAlveolar ridge width (ARW) was measured with a caliper immediately before (ARW1) and after SCT (ARW2) with a caliper. Existing CBCT scans taken at least 5 years postoperatively were used to assess the healed ARW (ARWF), buccal bone thickness (BBT), and lingual/palatal bone thickness (L/PBT) at 0, 3, and 5 mm apically from implant platform level (IPL). The distance between IPL and buccal bone crest (IPL‐BBC) was also measured. Findings were compared with Wilcoxon and Student's t tests (p < .05).ResultsRecords of thirty patients with 85 implants were included. Eleven patients (31 implants) presented CBCT scans taken in two separate occasions, resulting in 116 measurements. Tomographic follow‐up ranged from 5 to 18 years (11.5 ± 4.18 years). Mean ARW increased from 3.2 ± 0.6 to 6.6 ± 0.48 mm after SCT, but significantly reduced overtime to 4.46 ± 0.83 mm (ARWF) (p < .0001). Mean BBT was 0.5 ± 0.9, 1.3 ± 0.9, and 2.0 ± 1.2 mm, while mean L/PBT was 0.9 ± 0.7, 1.6 ± 0.9, and 2.1 ± 1.0 mm at 0, 3, and 5 mm from IPL, respectively. IPL‐BBC distance varied up to 8.7 mm (1.4 ± 2.0 mm), with 56/116 measurements (51/85 implants) showing IPL‐BBC = 0 mm.ConclusionAlthough SCT with simultaneous implant placement can predictably increase ARW postoperatively, ARW tended to significantly reduce over time, due to reductions in BBT and L/PBT, especially coronally. Nonetheless, 60% of the implants still presented some buccal bone at IPL.