bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation of the Efficacy of Using Observed Lightning to Improve Convective Lightning Forecasts
Authors: Lynn Barry H. , Kelman Guy , Ellrod Gary 
Published: May 2014

Abstract
Dynamic lightning forecasts [total and cloud to ground (CG)] were produced on a convection-allowing forecast grid with 4-km grid spacing with lightning assimilation (ASML) and without lightning assimilation [control (CNTL)]. A dynamic scheme produces time- and space-dependent potential electrical energy, which then converts this energy into lightning (e.g., number per hour per grid element). The assimilation scheme uses observed, gridded total lightning to determine how much water vapor is added at constant temperature in the mixed-phase region, leading to a convective response. ASML and CNTL lightning forecasts were compared to observed total and CG lightning. Four case studies—each representing a different type of convective regime—demonstrate that the spatial distribution and intensity of forecast lightning were improved when lightning assimilation was used. Over 3 days in March 2012, eight 18-h lightning forecasts quantified the advantages in forecast accuracy. Equitable threat scores for forecast CG lightning associated with strong [25 (3 h)−1], very strong [50 (3 h)−1], and extreme [100 (3 h)−1] events were significantly more accurate for convective storms that developed in forecasts with lightning assimilation than without. Improvements in forecasts of very strong and extreme events occurred out to 9 h of forecast time, while the forecasts of strong events showed improvement out to 15 h. Spurious convection was removed with filtering in one case study, which led to a notable improvement in the timing and intensity of the squall line. Sensitivity tests examined the utility of this filtering approach, and the importance of reducing mass imbalances liable to occur when too much water vapor mass is introduced into the model.
Machine Learning Enhancement of Storm-Scale Ensemble Probabilistic Quantitative Precipitation Forecasts
Authors: Gagne David John , McGovern Amy , Xue Ming 
Published: May 2014

Abstract
Probabilistic quantitative precipitation forecasts challenge meteorologists due to the wide variability of precipitation amounts over small areas and their dependence on conditions at multiple spatial and temporal scales. Ensembles of convection-allowing numerical weather prediction models offer a way to produce improved precipitation forecasts and estimates of the forecast uncertainty. These models allow for the prediction of individual convective storms on the model grid, but they often displace the storms in space, time, and intensity, which results in added uncertainty. Machine learning methods can produce calibrated probabilistic forecasts from the raw ensemble data that correct for systemic biases in the ensemble precipitation forecast and incorporate additional uncertainty information from aggregations of the ensemble members and additional model variables. This study utilizes the 2010 Center for Analysis and Prediction of Storms Storm-Scale Ensemble Forecast system and the National Severe Storms Laboratory National Mosaic & Multi-Sensor Quantitative Precipitation Estimate as input data for training logistic regressions and random forests to produce a calibrated probabilistic quantitative precipitation forecast. The reliability and discrimination of the forecasts are compared through verification statistics and a case study.
From Learning to Knowing: A Psychological–Neurological Approach to Explain the Human Capital Formation Process
Authors: Tamilina Larysa , Tamilina Natalya 
Published: May 2014

By drawing on neurological and psychological theories of learning, our study introduces a new conceptual framework to analyze the role that learning plays in knowledge and skill acquisition. Learning is modelled through four mechanisms defined as individuals’ participation in formal, non-formal and informal learning as well as learning-by-doing. Our analysis demonstrates heterogeneity in how various learning mechanisms affect people’s overall stock of human capital. Additionally, the proposed analytical framework points to the existence of complementarity between the four learning forms and suggests that participation in all of them is needed to maximize the process of human capital formation. These propositions are tested empirically with the Adult Literacy and Life Skills Survey data (2003) utilizing a variety of statistical techniques. JEL: I21, J01, J24, J28, J88
The Nature of the Business Group: Power, Relational Contracts and Scope
Authors: Kali Raja 
Published: May 2014

We propose a framework for understanding the business group, a hybrid organizational form that occupies the middle ground between firm and market and is a prominent feature of emerging economies. These organizations are characterized by varying levels of diversification and integration. We provide an explanation for the covariation, both positive and negative, in the scope, scale and ‘strength’ of integration of business groups. This notion of integration embodies the strength of ties that connect disparate subsidiary activities to the core of the business group, and is, we believe, novel to the theory of the firm. We also suggest the framework may be useful for understanding internal organizational hierarchy and multiproduct firms. JEL: L22, L14, M13, D23
Expression of eukaryotic initiation factor 4 E in hypopharyngeal carcinoma
Authors: Han Min , Wang Wei , Wang Lin , Jiang Yan 
Published: May 2014

Objectives To investigate the expression of eukaryotic initiation factor 4 E (eIF4E) in hypopharyngeal carcinoma compared with benign lesions, and the relationships between eIF4E expression and various clinicopathological parameters. Methods Expression of eIF4E was analysed retrospectively in specimens from hypopharyngeal carcinomas and benign hypopharyngeal lesions using immunohistochemical staining and Western blotting. Tumours were classified using the tumour–node–metastasis staging system and the degree of histological differentiation was assessed. Results A total of 55 hypopharyngeal carcinoma and 20 benign specimens were analysed. All the hypopharyngeal carcinoma samples were positive for eIF4E expression on immunohistochemistry, whereas the benign lesions were negative or weakly positive. Semi-quantitative assessment (eIF4E score) showed that eIF4E expression was significatly higher in hypopharyngeal carcinoma than in benign lesions. On Western blotting, eIF4E expression assessed using integrated optical density (IOD) was significantly higher in hypopharyngeal carcinoma than in benign lesions. The eIF4E score and IOD value were significantly associated with tumour stage, lymphatic metastasis and degree of differentiation. The IOD value was significantly higher in recurrent compared with initial cases. Conclusions eIF4E may play an important role in the development and metastasis of hypopharyngeal carcinoma;its expression may be helpful in establishing the diagnosis, stage and prognosis of this tumour type.
Central nervous system infection due to Mycobacterium haemophilum in a patient with acquired immunodeficiency syndrome
Authors: Buppajarntham Aubonphan , Apisarnthanarak Anucha , Rutjanawech Sasinuj , Khawcharoenporn Thana 
Published: May 2014

Summary Mycobacterium haemophilum is an environmental organism that rarely causes infections in humans. We report a patient with acquired immunodeficiency syndrome who had central nervous system infection due to M. haemophilum. The diagnosis required brain tissue procurement and molecular identification method while the treatment outcome was unfavourable.
Changes in Philippine labour relations policy: Convergence or divergence of productivity, flexibility and welfare?
Authors: Sale Jonathan P , Sale Arlene B 
Published: May 2014

AbstractIn the first decade of the present century, a succession of changes to Philippine labour law and jurisprudence sought to contribute to productivity and social welfare by introducing greater industrial relations flexibility, based on collective bargaining and voluntary dispute settlement. The article examines whether these changes actually resulted in any shift from a rights-based system for resolving industrial disputation to a system based on workplace-level interest-based negotiation, and whether they were accompanied either by higher labour productivity or by improved social welfare. The analysis draws on a conceptual framework that identifies coherent national labour regulation systems as being based on a convergence of three institutional approaches – to the operation of labour markets, of labour relations and of social security. Broadly, such labour regulation systems can be classified as either civil law or common law based. The Philippine labour regulation system is shown to have a hybrid basis, whose origins are briefly traced by identifying the legacy of the colonial and post-colonial phases, the martial law era and the restoration of democracy in 1986. Whereas Australia, another hybrid system, appears to have achieved some coherence in changes to the regulation of industrial relations, labour markets and social welfare, in the Philippines, such changes have not converged. In the 1990s, efforts to mitigate the traditional legalistic and adversarial character of industrial relations through liberalisation of restrictions on the right to organise were cross-cut by the effects of the growing labour market flexibility that resulted from integration into the global economy. Legal changes between 1999 and 2011 have not fostered voluntary self-organisation of distributive bargaining at enterprise level. Union membership, collective bargaining coverage and numbers of workers involved in notified or actual industrial action have declined, while reliance on compulsory arbitration and monetary compensation claims has remained high. Labour productivity has not improved. Within the context of globalisation, the labour market is increasingly characterised by numerical flexibility and a prevalence of small enterprises. High unemployment levels and a large informal sector indicate divergence between the systems for regulating labour and welfare.
Early predictors of multiple sclerosis after a typical clinically isolated syndrome
Authors: Ruet Aurélie , Arrambide Georgina , Brochet Bruno , Auger Cristina , Simon Eva , Rovira Àlex , Montalban Xavier , Tintoré Mar 
Published: May 2014

Background: The 2010 McDonald criteria allow diagnosing multiple sclerosis (MS) with one magnetic resonance imaging (MRI) scan. Nevertheless, not all patients at risk fulfil criteria at baseline. Other predictive factors (PFs) are: age ≤40 years, positive oligoclonal bands (OBs), and ≥3 periventricular lesions. Objective: The purpose of this study was to evaluate the 2010 McDonald criteria performance and to assess other PFs in patients without dissemination in space (DIS). Methods: Patients with clinically isolated syndrome (CIS) underwent baseline MRI and OB determination with clinical and radiological follow-up. Adjusted hazard ratios (aHRs) for clinically definite MS were estimated for DIS, dissemination in time (DIT), and DIS+DIT. Diagnostic properties at two years were calculated. In cases without DIS, combinations of ≥2 PFs were assessed. Results: A total of 652 patients were recruited; aHRs were 3.8 (2.5–5.8) for DIS, 4.2 (1.9–9.2) for DIT, and 8.6 (5.4–13.8) for DIS+DIT. Sensitivities were 69.6%, 42.3%, and 36.4%, and specificities were 67.3%, 87.9%, and 90.2%, respectively. In patients without DIS, aHRs varied between 2.7–5.5 and specificities ranged from 73.5–89.7% for PF combinations. Conclusion: The high specificity of the 2010 McDonald criteria is confirmed. In patients without DIS, PF combinations could be helpful in identifying those at risk for MS.
Predictors for multiple sclerosis relapses after switching from natalizumab to fingolimod
Authors: Hoepner Robert , Havla Joachim , Eienbröker Christian , Tackenberg Björn , Hellwig Kerstin , Meinl Ingrid , Hohlfeld Reinhard , Gold Ralf , Kümpfel Tania , Kleiter Ingo 
Published: May 2014

Background: Risks of natalizumab (NAT) therapy have to be weighed against disease recurrence after stopping NAT. Objectives: The objective of this paper is to identify risk factors for recurrence of relapses after switching from NAT to fingolimod (FTY) in relapsing–remitting multiple sclerosis (RRMS). Methods: Patients ( n = 33) were treated with NAT for ≥1 year, and then switched to FTY within 24 weeks (mean follow-up on FTY 81.1 (SD 26.5) weeks). Annual relapse rates (ARR) and Expanded Disability Status Scale scores (EDSS) were assessed. Descriptive statistics, univariate logistic regression analysis, and receiver operating characteristic curves were conducted. Results: Overall, 20 patients (61%) had relapses after discontinuation of NAT and 16 (48%) during FTY therapy. The maximum incidence of relapses occurred between weeks 13–24 post-NAT. The last EDSS during the switching period predicted relapses during subsequent FTY therapy. EDSS >3 separated most powerfully between the groups (sensitivity 64%, specificity 88%) and significantly predicted relapses (relative risk 3.27, 95% CI: 1.5–7.3). Seventy-five percent of patients with EDSS ≤ 3 remained free of relapses, compared to 18% of patients with EDSS >3. Conclusions: There was an increase of the ARR in the first year after switching from NAT to FTY. Last EDSS during the switching period was a predictor of relapses during FTY.
Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis
Authors: Kvistad Silje , Myhr Kjell-Morten , Holmøy Trygve , Bakke Søren , Beiske Antonie G , Bjerve Kristian S , Hovdal Harald , Løken-Amsrud Kristin I , Lilleås Finn , Midgard Rune , Njølstad Gro , Pedersen Tom , Benth Jūratė Šaltytė , Wergeland Stig , Torkildsen Øivind 
Published: May 2014

Background: Previous reports indicate an association between Epstein-Barr virus (EBV) antibody levels and multiple sclerosis (MS) disease activity, but the results have been conflicting. Objectives: The objective of this paper is to study if EBV antibody levels reflect MRI disease activity in MS and examine the potential for EBV antibody levels as biomarkers for treatment response. Methods: A total of 87 MS patients were followed for two years prior to and during interferon beta (IFNB) treatment, with MRI examinations and serum measurement of IgM and IgG antibodies to viral capsid antigen (VCA), EBV nuclear antigen 1 (EBNA-1) and early antigen (EA). Associations between EBV antibody levels and MRI activity were assessed by a logistic regression model. Results: Higher anti-EBNA-1 IgG levels were associated with increased MRI activity, OR = 2.95 (95% CI 1.07–8.10; p = 0.036) for combined unique activity (CUA; the sum of T1Gd+ lesions and new or enlarging T2 lesions). Although most patients were anti-VCA IgM negative, there was an inverse association, OR = 0.32 (95% CI 0.12–0.84; p = 0.021) with CUA during IFNB treatment. Conclusions: This study supports an association between anti-EBNA-1 IgG levels and MS disease activity. We also found an inverse association with anti-VCA IgM levels during IFNB treatment not previously described, indicating anti-VCA IgM as a possible biomarker for IFNB treatment response.
Adaptive designs for identifying optimal biological dose for molecularly targeted agents
Authors: Zang Yong , Lee J Jack , Yuan Ying 
Published: May 2014

Background Traditionally, the purpose of a dose-finding design in cancer is to find the maximum tolerated dose based solely on toxicity. However, for molecularly targeted agents, little toxicity may arise within the therapeutic dose range and the dose–response curves may not be monotonic. This challenges the principle that more is better, which is widely accepted for conventional chemotherapy. Methods We propose three adaptive dose-finding designs for trials evaluating molecularly targeted agents, for which the dose–response curves are unimodal or plateaued. The goal of these designs is to find the optimal biological dose, which is defined as the lowest dose with the highest rate of efficacy while safe. The first proposed design is parametric and assumes a logistic dose–efficacy curve for dose finding, the second design is nonparametric and uses the isotonic regression to identify the optimal biological dose, and the third design has the spirit of a ‘semiparametric’ approach by assuming a logistic model only locally around the current dose. Results We conducted extensive simulation studies to investigate the operating characteristics of the proposed designs. Simulation studies show that the nonparametric and semiparametric designs have good operating characteristics for finding the optimal biological dose. Limitations The proposed designs assume a binary endpoint. Extension of the proposed designs to ordinal and time-to-event endpoints is worth further investigation. Conclusion Among the three proposed designs, the nonparametric and semiparametric designs yield consistently good operating characteristics and thus are recommended for practical use. The software to implement these two designs is available for free download at http://odin.mdacc.tmc.edu/~yyuan/ .
A systematic review of barriers and facilitators to participation in randomized controlled trials by Indigenous people from New Zealand, Australia, Canada and the United States
Authors: Glover Marewa , Kira Anette , Johnston Vanessa , Walker Natalie , Thomas David , Chang Anne B. , Bullen Chris , Segan C. J. , Brown Ngiare 
Published: May 2014

Issue: Many randomized controlled trials (RCTs) are conducted each year but only a small proportion is specifically designed for Indigenous people. In this review we consider the challenges of participation in RCTs for Indigenous peoples from New Zealand, Australia, Canada and the United States and the opportunities for increasing participation. Approach: The literature was systematically searched for published articles including information on the barriers and facilitators for Indigenous people’s participation in health-related RCTs. Articles were identified using a key word search of electronic databases (Scopus, Medline and EMBASE). To be included, papers had to include in their published work at least one aspect of their RCT that was either a barrier and/or facilitator for participation identified from, for example, design of intervention, or discussion sections of articles. Articles that were reviews, discussions, opinion pieces or rationale/methodology were excluded. Results were analysed inductively, allowing themes to emerge from the data. Key findings: Facilitators enabling Indigenous people’s participation in RCTs included relationship and partnership building, employing Indigenous staff, drawing on Indigenous knowledge models, targeted recruitment techniques and adapting study material. Challenges for participation included both participant-level factors (such as a distrust of research) and RCT-level factors (including inadequately addressing likely participant barriers (phone availability, travel costs), and a lack of recognition or incorporation of Indigenous knowledge systems. Implication: The findings from our review add to the body of knowledge on elimination of health disparities, by identifying effective and practical strategies for conducting and engaging Indigenous peoples with RCTs. Future trials that seek to benefit Indigenous peoples should actively involve Indigenous research partners, and respect and draw on pertinent Indigenous knowledge and values. This review has the potential to assist in the design of such studies.
Ecological Selves and Organizational Leadership Values that Matter
Authors: Rogers Katrina S. 
Published: May 2014

One striking feature in the sweep of history is the extent to which humans have manipulated the natural environment to serve our needs and our desires. In the early written record, there are tales of deforestation and soil erosion (Plato, 360 BCE). As early as the seventeenth century, natural historians compared the grasslands around villages to inhabited areas and speculated on the consequences of human activity on natural systems ( Goudie, 2006 , p. 3). The onset of the industrial revolution in Western Europe combined with a growing understanding and knowledge base of science has rendered a circumstance of uncontrolled manipulation of the ecosystems and ever finer ways to measure these consequences. This article is an invitation to challenge us as scholars and practitioners to seek understanding as companies and other organizations take up their roles in a world that we are transforming irrevocably. Why does it matter, after all, that we seek to build a body of knowledge around corporate functioning? It is my intention that this article helps us ponder and reflect on that question.
Interaction of body mass index and hemoglobin concentration on blood pressure among pregnant women in Guangxi, China
Authors: Zhong Qiuan , Xu Jiangyan , Long Yingquan , Deng Yingying , Hu Jinlan , Li Xiaofei , Qiu Xiaoqiang 
Published: May 2014

Abstract

Background
Body mass index (BMI) and hemoglobin (Hb) are positively associated with hypertensive disorders among pregnant women. The aim of this study was to estimate a potential interaction between high BMI and high Hb concentrations on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in pregnancy.

Methods
We recruited 4497 single-birth women aged 18–43 years who received routine antenatal care at three hospitals of Guigang, Guangxi, China, from December 2007 to January 2011. Of 4497 participants, 3472 women were in the first trimester, with following up, 2986 women and 2261 women were left in the second and third trimester, respectively. Clinical data were derived from medical records of each woman. We used multivariable linear regression, by trimesters of pregnancy, to evaluate the associations of high BMI and high Hb concentrations with SBP and DBP according to cross-sectional design.

Results
In multivariable analyses, BMI was positively associated with SBP throughout all trimesters, but the corresponding association for Hb concentrations only in the first trimester, whereas both BMI and Hb concentrations were positively associated with DBP in the first and third trimesters. After full adjustment for confounding, the average differences in SBP and DBP comparing women with high BMI and high Hb to those with non-high BMI and non-high Hb were 2.9 mmHg (95% CI: 0.8 to 5.0 mmHg) and 3.9 mmHg (95% CI: 1.5 to 6.3 mmHg) in the first trimester, 2.6 mmHg (95% CI: 0.4 to 4.8 mmHg) and 1.5 mmHg (95% CI: -1.3 to 4.3 mmHg) in the second trimester, and 4.8 mmHg (95% CI: 2.3 to 7.4 mmHg) and 5.7 mmHg (95% CI: 3.2 to 8.3 mmHg) in the third trimester, respectively. With respect to the interaction, significant combined effects between high BMI and high Hb were confirmed on SBP (P = 0.02) and DBP (P = 0.004) in the third trimester, and the amount of interaction on SBP and DBP were 2.0 mmHg (95% CI: 0.1 to 3.9 mmHg) and 2.3 mmHg (95% CI: 0.4 to 4.3 mmHg), respectively.

Conclusion
Our findings suggest that high BMI and high Hb concentrations may have a synergistic effect on blood pressure in late stage of pregnancy.
Photogenerated charges and surface potential variations investigated on single Si nanorods by electrostatic force microscopy combined with laser irradiation
Authors: Wu Shan , Wu Zilong , Lin Dongdong , Zhong Zhenyang , Jiang Zuimin , Yang Xinju 
Published: May 2014

Abstract
Photogenerated charging properties of single Si nanorods (Si NRs) are investigated by electrostatic force microscopy (EFM) combined with laser irradiation. Under laser irradiation, Si NRs are positively charged. The amount of the charges trapped in single NRs as well as the contact potential difference between the tip and NRs' surface is achieved from an analytical fitting of the phase shift - voltage curve. Both of them significantly vary with the laser intensity and the NR's size and construction. The photogenerated charging and decharging rates are obtained at a timescale of seconds or slower, indicating that the Si NRs are promising candidates in photovoltaic applications.