bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatal pulmonary toxicity due to carfilzomib (Kyprolis™)
Authors: Lataifeh Abdel Rahman , Nusair Ahmad 
Published: June 2015

Introduction Carfilzomib (Kyprolis™) is a second-generation proteasome inhibitor for the treatment of relapsing multiple myeloma (MM). In 2012, carfilzomib was approved by Food and Drug Administration for the treatment of patients with relapsed MM who had received at least two prior therapies. We present a case of fatal pulmonary toxicity presumed secondary to carfilzomib. Clinical presentation A 61-year-old male was initially diagnosed with MM in 2003 for which he received multiple treatments. In 2013, he was started on carfilzomib for relapsing MM. After 24 h, the patient developed an acute respiratory distress syndrome for which he needed mechanical ventilation. One week later, patient developed diffuse alveolar hemorrhage and despite aggressive supportive care, the patient died after three weeks. Discussion The temporal relationship between the first exposure to carfilzomib and development of symptoms, and the exclusion of other possible etiologies, leads us to believe that our patient’s lung toxicity is a possible adverse reaction to carfilzomib. To the best of our knowledge, there are no previous reports of deaths due to carfilzomib-related pulmonary toxicity.
Computed tomographic findings in cats with mycobacterial infection
Authors: Major Alison , Holmes Andrea , Warren-Smith Christopher , Lalor Stephanie , Littler Rebecca , Schwarz Tobias , Gunn-Moore Danièlle 
Published: June 2015

Objectives The objective of this study was to describe the CT imaging findings associated with confirmed mycobacterial infection in cats. Methods CT images from 20 cats with confirmed mycobacterial disease were retrospectively reviewed. Five cats underwent conscious full-body CT in a VetMouseTrap device. All other cats had thoracic CT performed under general anaesthesia, with the addition of CT investigation of the head/neck, abdomen and limbs in some cases. Results Mycobacterial infection was seen most frequently in adult (mean age 7.4 years; range 0.6–14 years) neutered male cats (11/20). The most common infections were Mycobacterium microti (6/20) and Mycobacterium bovis (6/20). CT abnormalities were most commonly seen in the thorax, consisting of bronchial (9/20), alveolar (8/20), ground glass (6/20) or structured interstitial (15/20) lung patterns, which were often mixed. Tracheobronchial, sternal and cranial mediastinal lymphadenomegaly were common (16/20). Other abnormalities included abdominal (8/13) or peripheral (10/18) lymphadenomegaly, hepatosplenomegaly (7/13), mixed osteolytic/osteoproliferative skeletal lesions (7/20) and cutaneous or subcutaneous soft tissue masses/nodules (4/20). Conclusions and relevance CT of feline mycobacteriosis shows a wide range of abnormalities, often involving multiple organ systems and mimicking many other feline diseases. Mycobacteriosis should be considered in the differential diagnosis of thoracic, abdominal and skeletal disorders in cats.
Using surveillance data to reduce healthcare–associated infection: a qualitative study in Sweden
Authors: Ridelberg Mikaela , Nilsen Per 
Published: June 2015

Introduction: Healthcare-associated infection (HAI) surveillance data can be used to estimate the scope, spread and location of infections, monitor trends, evaluate preventive efforts, and improve practices, policy and facility planning. In Sweden, national point prevalence surveys (PPS) have been conducted twice yearly in all county councils since 2008. Aim: The aim of this study was to identify key obstacles concerning the HAI surveillance process. Methods: Twenty-two infection control practitioners (ICPs) from all county councils in Sweden were interviewed, using semi-structured interview guides. Data were analysed using qualitative content analysis. Results: Sixteen types of obstacles pertaining to four surveillance stages were identified. Most obstacles were associated with the first two stages, which meant that the latter stages of this process, i.e. the use of the results to reduce HAI, were underdeveloped. The ICPs observed scepticism towards both the PPS methodology itself and the quality of the HAI data collected in the PPS, which hinders HAI surveillance realising its full potential in Swedish healthcare.
Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis
Authors: Pepler Laura , Yu Pei , Dwivedi Dhruva J. , Trigatti Bernardo L. , Liaw Patricia C. 
Published: June 2015

Key PointsMutation of the PC-binding domain of EPCR results in viable mice that exhibit procoagulant and proinflammatory phenotype when challenged. EPCRR84A/R84A mice develop splenomegaly as a result of BM failure, suggesting that EPCR plays an important role in hematopoiesis.
Cartilage oligomeric matrix protein is a natural inhibitor of thrombin
Authors: Liang Ying , Fu Yi , Qi Ruomei , Wang Meili , Yang Nan , He Li , Yu Fang , Zhang Jian , Yun Cai-Hong , Wang Xian , Liu Junling , Kong Wei 
Published: June 2015

Key PointsCOMP negatively regulates hemostasis and thrombosis. COMP is a natural inhibitor of thrombin.
Best proximity point theorems for probabilistic proximal cyclic contraction with applications in nonlinear programming
Authors: Saadati Reza 
Published: June 2015

AbstractIn this paper, we derive a best proximity point theorem for non-self-mappings satisfied proximal cyclic contraction in PM-spaces and this shows the existence of optimal approximate solutions of certain simultaneous fixed point equations in the event that there is no solution. As an application we consider a nonlinear programming problem. Our results extend and improve the recent results of (Sadiq Basha in Nonlinear Anal. 74(17):5844-5850, 2011).
Systemic risk management and investment analysis with financial network analytics: research opportunities and challenges
Authors: Hu Daning , Schwabe Gerhard , Li Xiao 
Published: June 2015

Abstract
Recent economic crises like the 2008 financial tsunami has demonstrated a critical need for better understanding of the topologies and various economic, social, and technical mechanisms of the increasingly interconnected global financial system. Such a system largely relies on the interconnectedness of various financial entities such as banks, firms, and investors through complex financial relationships such as interbank payment networks, investment relations, or supply chains. A network-based perspective or approach is needed to study various financial networks in order to improve or extend financial theories, as well as develop business applications. Moreover, with the advance of big data related technologies, and the availability of huge amounts of financial and economic network data, advanced computing technologies and data analytics that can comprehend such big data are also needed. We referred this approach as financial network analytics. We suggest that it will enable stakeholders better understand the network dynamics within the interconnected global financial system and help designing financial policies such as managing and monitoring banking systemic risk, as well as developing intelligent business applications like banking advisory systems. In this paper, we review the existing research about financial network analytics and then discuss its main research challenges from the economic, social, and technological perspectives.
Phase Portrait of Single-Channel Ecg in Asseessment of Functional Reserves of Cardiovascular System
Authors: Минина  , Minina E. , Файнзильберг  , Faynzilberg L. 
Published: June 2015

To study and simulate of dynamic behavior of complex biomedical systems the methods of chaos theory and synergetics are used. These methods provide an opportunity to adequately disclose and analyze the mechanisms the functioning of a living com-plex system, considering the phase trajectory in the state space. When various approaches to the study of the behavior of biological systems in phase space, can &#34;produce&#34; separate diagnostic characteristics that didn’t duplicated by other methods of analysis, and complement each other.
Found that the original features of the phase portrait of single-channel ECG device that can be computed by appliance &#34;FAZAGRAF®&#34; with finger electrodes have an additional diagnostic value in quantifying the level of functional reserves of the cardiovascular system, and also have practical significance in the differential diagnosis of functional status and reserves cardiovascular system in different populations in screening studies in clinical practice and sports medicine.
It was found that the original characteristics of the phase portrait single-channel ECG: βT, STR, αQRS and σQRS, and significantly different in the groups with different levels of functional reserves of the cardiovascular system and have additional diagnostic value. Dynamics of changes in the characteristics of the phase portrait single channel ECG with stepwise increasing load quantitatively reflects the differences in the level of functional reserves and orientation of compensatory and adaptive processes.
Pharmacological Modulation of Compensatory Mechanisms Energy Metabolism in the Brain of Prenatal Alcoholic Animals
Authors: Соколик  , Sokolik E. , Егоров  , Egorov A. 
Published: June 2015

The studies have shown that drinking alcohol by woman during pregnancy can lead not only to a full fetal alcohol syndrome, but also causes less severe dysmorphic, cognitive and behavioral disordersl, i.e. fetal alcohol spectrum disorders, leads to low birth weight, fetal death, and other complications of pregnancy.
The purpose of this study was to investigate the influence of neuroprotective drugs tiocetam, cerebrocurin and piracetam on the marks of thin elements of energy metabolism and compensatory shunts in the brain of animals early age undergoing prenatal alcoholism.
In pregnant rats with alcoholism were found neuroprotective and nootropic effects of cerebrocurin and tiocetam after parenterally administered to newborn animals for a period of 25 days. The above drugs have a beneficial effect on the main elements of the energy metabolism on the neonatal brain.
On the severity of mitoprotective and energotropic mechanisms of neuroprotective action, aimed at reducing the negative impact of alcohol on the progeny, tiocetam and cerebrocurin far exceed basic nootropic drug piracetam.
Molecular-Epidemiological Monitoring of Strains of Streptococcus Pneumoniae Isolated from Elderly Patients with Community-Acquired Pneumonia
Authors: Чулакова  , Chulakova O. , Балабанова  , Balabanova L. , Мартынова  , Martynova A. , Шепарев  , Sheparev A. 
Published: June 2015

Community-acquired pneumonias in the elderly patients are the significant epidemiological problem for the public health of almost all countries. Especially urgent is the problem of microbiological and epidemiological monitoring for the S.pneumoniae strains as one of the ubiquitary pathogens, causing the community-acquired pneumonias and the other respiratory tract infections of various severities, what is determined by their different epidemiological significance.
Multiloci sequesterant is a promising method of molecular-epidemiological monitoring, identifying epidemically dangerous clones such ubiquitaria of the pathogen as S.pneumoniae.
The purpose of this research was to carry out the multilocus sequence typing of strains of pneumococcus isolated in the elderly patients with community-acquired pneumonias, bronchitis. Materials and methods were 14 strains of S.pneumoniae, isolated in patients with community-acquired pneumonias (7 of them – multiresistant), 8 strains were isolated from the patients with the chronic pulmonary obstructive diseases and 4 strains – from carriers of activators. Multilocus sequence typing was carried out according to method of M.C. Enright and B. G. Spratt (1998). Results: all strains, isolated in all populations were the related isolates of the species Streptococcus pneumoniae, the most of them (18 of 26) have a unique genotype, determining the presence of one sequence-type for each strain. From 14 strains, isolated from the elderly with community-acquired pneumonia, 6 were related to the profile Taiwan 19F-14. Among strains isolated from the patients with COPD, the prevalence of any genotype wasn’t identified. Conclusion: multilocus sequence typing allows to identify the new genotypes and to predict the appearing of epidemiologically dangerous strains with new proprieties.
The Role of Normobaric Hypoxic Therapy in the Formation of an Adequate Individual Style of Activity of Preschool Children
Authors: Сязина  , Syazina N. Yu. , Франтасова  , Frantasova E. 
Published: June 2015

A pilot study to assess the effects of normobaric therapy on the formation of an adequate individual style of activity for preschool children was carried out. In this study, 35 preschool children with neuropsychological disorders, including 18 boys and 17 girls, took part. The survey was carried out using the apparatus &#34;Aquatimer&#34;. The results of the study allowed the authors to conclude: intermittent therapy used in the rehabilitation process, can affect the physiological status of the preschool child and bioelectric activity of the brain. Indicators of emotional state, as well as the indicator of their functional asymmetry are of great diagnostic value, because the function of each hemisphere has its own specifics, which affects any human activity. The results of the research can be used not only psychologists, but also by teachers to diagnose emotional development of children, the reasons for their broken social adaptation and conflict.
Knowledge about the relationship between emotional state and the presence of functional asymmetry of the cerebral hemispheres allows to more accurately diagnose and correct communication characteristics of preschoolers with their peers, improve their socialization process and to widen the sphere of our influence on this process.
Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey
Authors: Adeli Khosrow , Raizman Joshua E , Chen Yunqi , Higgins Victoria , Nieuwesteeg Michelle , Abdelhaleem Mohamed , Wong Suzy L , Blais David 
Published: June 2015

AbstractBACKGROUNDIn a collaboration between the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) and the Canadian Health Measures Survey (CHMS), we determined reference value distributions using an a priori approach and created a comprehensive database of age- and sex-stratified reference intervals for clinically relevant hematologic parameters in a large household population of children and adults.METHODSThe CHMS collected data and blood samples from 11 999 respondents aged 3–79 years. Hematology markers were measured with either the Beckman Coulter HmX or Siemens Sysmex CA-500 Series analyzers. After applying exclusion criteria and removing outliers, we determined statistically relevant age and sex partitions and calculated reference intervals, including 90% CIs, according to CSLI C28-A3 guidelines.RESULTSHematology marker values showed dynamic changes from childhood into adulthood as well as between sexes, necessitating distinct partitions throughout life. Most age partitions were necessary during childhood, reflecting the hematologic changes that occur during growth and development. Hemoglobin, red blood cell count, hematocrit, and indices (mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) increased with age, but females had lower hemoglobin and hematocrit starting at puberty. Platelet count gradually decreased with age and required multiple sex partitions during adolescence and adulthood. White blood cell count remained relatively constant over life, whereas fibrinogen increased slightly, requiring distinct age and sex partitions.CONCLUSIONSThe robust dataset generated in this study has allowed observation of dynamic biological profiles of several hematology markers and the establishment of comprehensive age- and sex-specific reference intervals that may contribute to accurate monitoring of pediatric, adult, and geriatric patients.
Education of Older People for Combating Their Loneliness
Authors: Goriup Jana , Čagran Branka , Krošl Katja 
Published: June 2015

Abstract
The article discusses education of older people for combating their loneliness, the reasons for it, and its consequences. The current theoretical findings were the reason for the empirical study of the research problem by the authors. In the empirical part, some aspects of the life of older people regarding their residences were compared: among older people living with their relatives, alone, with a partner, or in a retirement home, with special regard to the reasons/causes for residence, and the feeling of loneliness and contacts with relatives. The obtained empirical results showed that older people living alone or in a retirement home are in a worse position compared to those living with relatives or with a partner. The most at risk are older people living alone.
(Re)Claiming Voices: Digital Storytelling and Second Language Learners
Authors: Grigsby Yurimi , Theard-Griggs Carolyn , Lilly Christopher 
Published: June 2015

Abstract
With almost five million English language learners in the United States, digital storytelling is increasingly being used in second language learning classrooms. As a teaching and learning strategy, digital storytelling can promote critical thinking, connect new content with prior knowledge, enhance memory, and foster confidence and motivation for learning. Digital stories possess unique narrative qualities that often center on identity negotiation and the ways culturally and linguistically diverse students make meaning out of their lives. Fostering hands-on, active learning, digital storytelling is an interactive way to include culturally and linguistically diverse students’ voices in a curriculum that may not easily represent them. Practical implementation of digital storytelling is included.
Magnesium alloys for vascular stents: the biological bases
Authors: Castiglioni Sara , Maier Jeanette A.M. 
Published: June 2015

AbstractBioabsorbable vascular stents in magnesium alloys provide an attractive alternative to standard stainless steel metal stents, because of their adequate radial force, high biocompatibility, low thrombogenicity and intrinsic dissolution in body fluids. Since magnesium is the major component of the alloys, high concentrations of this element can be achieved in the local microenvironment as a results of corrosion. Magnesium is known to grant cardiovascular protection and to be beneficial for the cells of the vascular wall. This review summarizes present knowledge about the effects of high magnesium levels on smooth muscle and endothelial cells.
Lipoxin A4 methyl ester alleviates vascular cognition impairment by regulating the expression of proteins related to autophagy and ER stress in the rat hippocampus
Authors: Jia Yanqiu , Jin Wei , Xiao Yining , Dong Yanhong , Wang Tianjun , Fan Mingyue , Xu Jing , Meng Nan , Li Ling , Lv Peiyuan 
Published: June 2015

AbstractSince autophagy and endoplasmic reticulum stress mechanisms are involved in some neurodegenerative and cerebral vascular diseases, we suspected that similar mechanisms might participate in vascular cognitive impairments induced by chronic cerebral hypoperfusion. Lipoxin A
Convergence to equilibrium of gradient flows defined on planar curves
Authors: Novaga Matteo , Okabe Shinya 
Published: June 2015

Abstract
We consider the evolution of open planar curves by the steepest descent flow of a geometric functional,
with different boundary conditions.
We prove that, if any set of stationary solutions with fixed energy is finite,
then a solution of the flow converges to a stationary solution as time goes to infinity.
We also present a few applications of this result.
9α-hydroxyparthenolide in Zoegea leptaurea subsp. mesopotamica (Czerep.) Rech. (Asteraceae)
Authors: Nawrot Joanna , Dawid-Pać Renata , Kaczerowska-Pietrzak Kinga , Urbańska Maria , Nowak Gerard 
Published: June 2015

Summary
From the aerial parts of Zoegea leptaurea subsp. mesopotamica (Czerep.) Rech. (syn Zoegea mesopotamica Czerep.), 9α-hydroxyparthenolide was isolated. This compound was identified by spectral methods (1H NMR and 13C NMR). This research confirmed earlier indications about the presence of 4,5-epoxygermacranolides in the Zoegea L. genus. Thus, distinctive chemistry feature of plants in this taxon has chemotaxonomic implications.
Oil yield and fatty acid profile of seeds of three Salvia species. A comparative study
Authors: Ben Farhat Mouna , Chaouch -Hamada Rym , Landoulsi Ahmed 
Published: June 2015

Summary
A comparative study of the oil yield and fatty acid composition of three Salvia species seeds collected in different locations has been conducted. Seed oil extraction was made using a Soxhlet-extractor and fatty acid analysis was undertaken using a GC-FID. The effect of the collecting site on oil yield, as well as the content of individual fatty acid and total fatty acid and fatty acid content was significant. Seed oil yield varied from 14.94 to 22.83% and the total fatty acids ranged from 67.36 to 82.49 mg/g DW. α-Linolenic (24.02-49.19%), linoleic (20.13-42.88%), oleic (12.97-17.81%) and palmitic (8.37-16.63%) acids were the most abundant fatty acids in all analyzed samples. α-Linolenic acid was found to be the major fatty acid in S. verbenaca and S. officinalis species, however, S. aegyptiaca was characterized by the prevalence of linoleic acid. Among the unsaturated fatty acids, which were represented in all samples in high amounts (78.16-89.34%), the polyunsaturated fatty acids (α-linolenic and linoleic acids) showed important levels ranging from 63.09 to 74.71%. Seeds of S. verbenaca were the richest in polyunsaturated fatty acids.
Psychoactive plants used in designer drugs as a threat to public health
Authors: Rondzisty Agnieszka , Dziekan Karolina , Kowalska Aleksandra 
Published: June 2015

Summary
Based on epidemiologic surveys conducted in 2007-2013, an increase in the consumption of psychoactive substances has been observed. This growth is noticeable in Europe and in Poland. With the ‘designer drugs’ launch on the market, which ingredients were not placed on the list of controlled substances in the Misuse of Drugs Act, a rise in the number and diversity of psychoactive agents and mixtures was noticed, used to achieve a different state of mind. Thus, the threat to the health and lives of people who use them has grown. In this paper, the authors describe the phenomenon of the use of plant psychoactive substances, paying attention to young people who experiment with new narcotics. This article also discusses the mode of action and side effects of plant materials proscribed under the Misuse of Drugs Act in Poland.