bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation testing of OUTPATSAT-35RT questionnaire to assess satisfaction in patients on outpatient radiotherapy in a large Indian cohort
Authors: Manjali Jifmi J. , Keluskar Geyata , Patel Ruchi , Bano Nazia , Shaikh Farnaz , Malhotra Rahat , Mani Shaktivel , Kumar Anuj , Sinha Shwetabh , Krishnamurthy Revathy , Dasgupta Archya , Chatterjee Abhishek , Tibdewal Anil , Pathak Rima , Mummudi Naveen , Wadasadwala Tabassum , Laskar Sarbani G. , Sarin Rajiv , Agarwal Jai Prakash , Gupta Tejpal 
Published: August 2024

ABSTRACT

Background:
This study reports the psychometric properties of OUTPASAT-35RT questionnaire from a large Indian cancer cohort treated with ambulatory radiotherapy (RT) at a tertiary-care comprehensive cancer center.

Materials and Methods:
Adults with a pathologically proven diagnosis of cancer undergoing fractionated RT (≥10 fractions) with the ability to read and understand English, Hindi, or Marathi were accrued after written informed consent. Patients were administered a language-appropriate version of OUTPATSAT-35RT along with European Organization for Research and Treatment of Cancer (EORTC) generic quality-of-life questionnaire (QLQ-C30) at conclusion of RT (±3 days). Psychometric properties of OUTPATSAT-35RT were analyzed.

Results:
A total of 314 patients were accrued between 2018 and 2020. A negligible floor effect (<2%) but a high ceiling effect (>15%) was observed for OUTPATSAT-35RT. Multi-trait analysis revealed satisfactory validity and reliability of the questionnaire. Pearson’s correlation coefficient (PCC) of individual item score with own scale was >0.4 suggesting good convergent validity. Discriminant validity was satisfactory as the PCC with its own scale/own domain was greater than with other scales of the same domain and other domains of OUTPATSAT-35RT, respectively. Correlation of scales of OUTPATSAT-35RT with scales of QLQ-C30 demonstrated acceptable divergent validity (all values of PCC <0.3). Cronbach’s alpha was >0.7 suggesting good internal consistency. Test–retest reliability was good with intra-class coefficient being >0.7. Economic status was the only socio-demographic factor correlating significantly with OUTPATSAT-35RT scores; satisfaction of patients with the delivery of care increased with increasing family income.

Conclusion:
The psychometric properties of OUTPATSAT-35RT were found to be acceptable and satisfactory during validation testing in a large Indian cohort.
Evaluation of gross target volumes in CECT vs MRI in head and neck cancer and its implication on concordance indices and dose-volume parameters of IMRT treatment plan
Authors: Deshmukh Milind , Jain Bharati M. , Singh Ashok , Kalbande Pallavi , Tayade Atul , Datta Niloy R. 
Published: August 2024

ABSTRACT

Background:
Although radiotherapy treatment planning (RTP) for head and neck cancers (HNCs) is based on contrast enhanced computed tomography (CECT), soft tissue contrasts are better evident on magnetic resonance imaging (MRI). We therefore evaluated dose-volume histogram (DVH) parameters along with concordance index (ConI), conformity index (CI), and homogeneity index (HI) of planning target volume (PTV) of GTV delineated on CECT vs MRI in HNCs enrolled for intensity modulated radiotherapy (IMRT).

Methodology:
Forty consecutive HNCs were enrolled in this study. All underwent CECT and MRI simulations with immobilization devices. GTVp and GTVn were delineated independently on CECT and MRI images. Corresponding MRI volumes were then copied to CECT. IMRT plans were generated on the CECT incorporating PTV margins. DVH parameters of PTVpn for both CECT and MRI were compared. In addition, mean (±SD) percentage difference of GTVp, GTVn, GTVpn, ConI, CI, and HI were evaluated using paired t-test.

Results:
The GTVp (P = 0.005), GTVn (P = 0.009), and GTVpn (P < 0.001) delineated on MRI were found to be significantly larger than GTV delineated on CECT. In eight patients, GTV outlined on CECT were larger than MRI. Significant mean differences in CECT vs MRI of CI (P < 0.001), HI (P < 0.001), ConI (P < 0.001), and DVH parameters (D2, D95, D98, V95, and V100 all P < 0.001; D50: P = 0.009) were noted.

Conclusion:
The GTVs and corresponding PTVs were significantly larger on MRI compared to CECT. This resulted in significant differences in DVH parameters, CI, ConI, and HI. This could be improved by co-registered MRI-CECT volumes during routine IMRT treatment planning for HNCs.
Receptor subtype and outcome of breast cancer – Single-center experience from North India
Authors: Banday Saquib Z. , Ayub Maniza , Rasool Malik T. , Ahmed Sheikh Z. , Banday Aaqib Z. , Naveed Shah , Guru Faisal R. , Mir Mohmad H. , Akhter Shareefa , Bhat Mudasir H. , Yaseen Syed B. , Afroz Fir , Bhat Gull M. , Lone Mohammad M. , Aziz Shiekh A. 
Published: August 2024

ABSTRACT

Aims/Objectives:
In resource-limited settings, data regarding the impact of molecular/receptor subtypes on breast cancer (BC) are sparse. In this single-center retrospective study from north India, we analyze the outcomes of various molecular subtypes of BC.

Materials and Methods:
Females with biopsy-proven BC who were treated at our State Cancer Institute from 2014-2018 were included. Data regarding clinicopathological parameters and follow-up details were evaluated. For data analysis, cancers were categorized into 4 subtypes: HR+HER2–, HR+HER2+, HR–HER2+, and HR–HER2–.

Results:
Among 944 patients included, HR+HER2– (49.1%) and HR+HER2+ (13.1%) were the most and least common subtypes, respectively. The receptor subtype significantly impacted overall survival (OS). HR+HER2– cancers had the best outcomes while HR–HER2– cancers fared worst (3-yr OS of 94.3% and 69.1%, respectively). On subgroup analysis, the molecular subtype continued to significantly impact OS in patients with tumor grades II and III, disease stages II and III, and age groups of <40 and 40-60 years, respectively (HR–HER2– cancers had the lowest cumulative survival in each subgroup). In patients with metastatic BC, all molecular subtypes except HR+HER2– had a dismal prognosis.

Conclusions:
Overall and across various subgroups, patients with triple-negative BC had the poorest outcomes. Ensuring optimal treatment utilization including affordable access to personalized tailored therapy is the need of the hour to improve long-term outcomes in these patients.
Adhesive Strength of Glass Fiber-Reinforced Posts with Silane Conditioning Versus Universal Adhesive System Conditioning: An In Vitro Study
Authors: Martínez-Campos Reynaldo , Vilchez-Reynaga Luzmila , Santander-Rengifo Flor , López-Gurreonero Carlos , Aliaga-Mariñas Ana , Aroste-Andía Rosa , Cayo-Rojas César 
Published: August 2024

Abstract

Aim:
The current study compared the push-out adhesive strength of glass fiber-reinforced posts with a silane-treated surface versus a universally adhesive-treated surface. In both cases, a universal self-adhesive cement was used.

Materials and Methods:
Thirty bovine teeth were used in an in vitro experiment. Through cutting, the root and coronal sections were divided. Subsequently, the manufacturer’s recommendations were followed for the placement of glass fiber-reinforced posts through root canal therapy, gutta-percha removal, and canal shaping. On the basis of how the posts were treated prior to cementation, the samples were split into three groups (n = 10). Posts in group A (control) did not get any prior treatment. Posts in group B had previously received a silane treatment. Posts in Group C had previously been coated with universal adhesive. Following the application of RelyX Ultimate universal self-adhesive cementation, the samples were segmented and subjected to a Push-Out test at a speed of 1 mm/min on a universal testing apparatus. Intergroup ANOVA was used to evaluate the adhesive strength means (measured in MPa), and Tukey’s post hoc test was performed afterward, with a significance level of P < 0.05.

Results:
Compared to the glass fiber-reinforced posts pre-treated with silane (P = 0.003) and the control group (P < 0.001), the adhesive strength of the posts pre-treated with universal adhesive was significantly higher. Similarly, the adhesive strength of the glass fiber-reinforced posts that had been pre-treated with silane was considerably higher than that of the control group (P = 0.012).

Conclusion:
Posts reinforced with glass fiber and pre-treated with universal adhesive exhibited notably greater adhesive strength compared to those pre-treated with silane. When compared to utilizing universal self-adhesive cement without pre-treatment, both pre-treatment techniques greatly increased the adhesive strength of glass fiber-reinforced posts.
Prenatal Ultrasound and Magnetic Resonance Findings of Glutaric Acidemia Type 1 and Its Challenges in Prenatal Diagnosis
Authors: Wang Jo-Ting , Lee Han-Jui , Chang Tung-Yao 
Published: August 2024

Abstract
Glutaric acidemia type 1 (GA1) presents unique challenges in prenatal diagnosis, especially in cases with no family history. This review article aims to review and present the prenatal ultrasound and magnetic resonance findings of GA1 and consolidate key insights into the difficulties associated with GA1 prenatal diagnosis and the neuroimaging features that require careful differentiation during the diagnostic process.
The effect of prone positioning on surgical pleth index in patients undergoing spine surgery under general anesthesia – A prospective observational study
Authors: Musti Smita , Chakrabarti Dhritiman , Bansal Sonia 
Published: August 2024

Background and Aims:
Surgical Pleth Index (SPI) provides an objective assessment of nociception - anti-nociception balance but is influenced by multiple confounders. The effect of change of position on SPI, has not been studied extensively. The aim of the study was to observe the effect of prone positioning on SPI and its correlation with hemodynamic variables, in patients undergoing lumbar and thoracic spine surgery.

Material and Methods:
This prospective observational pilot study included 14 patients. In addition to hemodynamic monitoring, SPI, entropy and pulse pressure variability (PPV) were monitored. Propofol and Fentanyl infusions were used for maintenance of anesthesia. The patients were made prone on bolsters and all the variables were recorded every 5 minutes in supine position and after making prone for 20 minutes, before and after incision, muscle splitting and laminectomy.

Results:
Comparing the last value of the variables in the supine position with those immediately after making prone, SPI increased by 16.36 units (P = 0.003), followed by gradual reduction over the next 20 minutes. Mean arterial pressure and heart rate increased transiently (Pvalue = 0.028 and 0.025, respectively) without any significant change in PPV. Surgical incision also led to a significant increase in SPI.

Conclusion:
Prone positioning leads to significant increase in SPI, probably due to increased sympathetic tone.
Overview of obesity and effect of bariatric surgery in Aljouf area, Saudi Arabia
Authors: Felemban Hana Bahraldeen , Mutlaq Baseem Saber , Hamoud Alhassan Ismail , Ziyad Alluheed Mohamad , Takia Yousfi Iman , Abdulkarim Alolayan Mohammed , Ibrahim Albahooth Khalid , Zaki Alsharari Abdulrahman 
Published: August 2024

Abstract

Introduction:
Studies have shown that obesity is increasingly prevalent in Saudi Arabia (SA). As the nation has witnessed economic growth and associated lifestyle changes, obesity has emerged as a significant problem, according to the findings of Salem et al. in 2022. Although obesity has reached a prevalence of 41.1% in males and 77.6% in females in SA,research on this topic has been lacking.

Aim:
To highlight the prevalence of obesity in Aljouf area and demonstrate the effect of bariatric surgery on patient health.

Methods:
We conducted a retrospective chart review using relevant demographic and clinical data from 2020 onward collected from the Arcus Air system. Statistical analysis: Descriptive statistical analysis was performed, and numerical data were presented as median (interquartile range [IQR]) and categorical data as frequencies and percentages. Numerical variables were tested for normality using the Shapiro-Wilk normality test. Statistical significance was set at P<0.05 were considered significant. STATA® 15.1 was employed for the analysis.

Results:
We included 196 patients who underwent bariatric surgery. Their median age was 34 years (range,17–52), and females constituted 65% . Approximately 80% of the study subjects had a baseline body mass index (BMI) of >40kg/m2, and approximately 13% had diabetes mellitus (DM). Ten days after surgery, a significant decline was observed in the median BMI of 39.3 (37.3–41.4) compared to the pre-operative median BMI of 42 (40–44 ). A further significant decrease was observed in BMI three months later (median BMI: 33.7 [31–36.98]). This was paralleled by improvement in HbA1c levels in patients with DM or pre-diabetes, with a median value of 5.5% (5.4–6.6) three months after surgery compared to a baseline median of 6.6% (6.2–7.4).

Discussion:
The data demonstrated that obesity was more prevalent in females than males. We observed a statistically significant change in weight loss based on BMI in the first ten days following the procedure (39; 37.2–41.3) and again at the three-month follow-up (33.7; 31–36.98), P <0.0001. Patients with comorbidities such as DM and hypertension showed significant health improvements, unlike those with high high-density or low-density lipoprotein levels.

Conclusion:
Bariatric surgery is an effective approach to weight reduction in patients with obesity. The study demonstrated significant reductions in comorbidities (DM and HTN), in addition to overall health improvements. There is a need to raise awareness of obesity’s effects on society. Further studies are required in northern regions.
A comprehensive review on creating curricula to teach robotic surgery
Authors: Kaaki Suha K. 
Published: August 2024

Abstract
Since 2017, robotic-assisted surgery has significantly grown, enabling surgeons to overcome weaknesses interrelated to traditional laparoscopic surgery. Therefore, the high growth of robotic-assisted surgery has necessitated the development of a curriculum that will support effective learning of this technology. Although different curricula have been developed and validated over the years, researchers have different views on their effectiveness; some of them reveal that some are better than others. This review aims to highlight and discuss numerous curricula that have been developed to teach robotic-assisted surgery. In understanding the creation of curricula that can be used to teach robotic surgery, comprehensive searches of literature materials from PubMed, MEDLINE and Embase were conducted. After the investigation, research articles on robotic surgery curricula published in English from 2014 to 2022 were located and used. Based on the research materials, it was established that creating and implementing a standard curriculum incorporating simulation training, mentorship, didactic lessons, and hands-on practice is one of the best when applied in robotic surgery training. This is because it shows a significant improvement in didactic, cognitive, psychomotor, and communication skills when implemented. Besides, the results indicated that other curriculum programs such as da Vinci® Technology Training Pathway and Fundementals of Robotic Surgery are crucial in creating a curriculum to teach robotic surgery since they influence procedure-specific skills and knowledge, including but not limited to instrumentation, patient selection, system and patient positioning, preoperational operation, procedural steps, port placement, management, and complications. Therefore, this shows that to achieve the most effective training curricula for robotic surgery, it is vital to combine several teaching methods for surgeons to achieve great expertise.
Incidental finding of carcinoid tumor postappendectomy and a review from Gulf Cooperation Council countries
Authors: Alotaibi Abdulrahman Muaod , Alfaiel Emad Ahmed , Alsatouf Khaled Aabdulmawla , Aloufi Ayah , Moshref Leena Hatem 
Published: August 2024

Abstract
Scanty of research in Gulf Cooperation Council countries address the neuroendocrine tumors (NETs) with a gap in reported cases after appendectomy in Saudi Arabia compared to others. This study aimed to describe the experience of a single tertiary care private hospital in the management of incidentally discovered NETs after appendectomy and to review the series from nearby countries. A retrospective data review was done between January 2016 and January 2018 in the Surgery Department at Dr. Soliman Fakeeh Hospital (Jeddah, Saudi Arabia). Among 458 appendectomies, 3 appendiceal carcinoid tumors were identified (0.67%). All patients present with acute appendicitis. The carcinoid tumor was not diagnosed preoperatively. The mean diameter of the appendix was 10 mm, while the histopathology diameter of the discovered carcinoid was 5 mm. There were no postoperative complications. All patients were disease-free at follow-up. None of them received reoperation or adjuvant therapy.
Is the development of arrhythmia predictable in rheumatoid arthritis?
Authors: Gülkesen Arif , Yıldırım Uslu Emine , Akgöl Gürkan , Alkan Gökhan , Ali Kobat Mehmet , Ali Gelen Mehmet , Fuad Uslu Muhammed 
Published: August 2024

Objectives: This study aimed to determine whether there is a difference in the electrocardiography (ECG) measurements of healthy controls and rheumatoid arthritis (RA) patients and to predict whether they can be used to determine the risk of arrhythmia in patients.
Patients and methods: The prospective study included 50 cardiac asymptomatic RA patients (38 males, 12 females; mean age: 46.8±9.1 years; range, 18 to 60 years) who met the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology RA criteria and 50 healthy volunteers (34 males, 16 females; mean age: 43.4±10.4 years; range, 18 to 60 years) as a control group between June 1, 2022, and August 31, 2022. Disease activity of the patients was calculated with the Disase Activity Score (DAS28). Heart rate, minimum and maximum QT intervals, QT dispersion, minimum and maximum P waves, P wave dispersion (Pd), minimum and maximum Tp-e intervals, Tp-e dispersion, minimum and maximum corrected QT (QTc) intervals, QTc dispersion, and the Tp-e/QTc ratio in ECGs were calculated.
Results: The mean disease duration of the RA group was 9.09±5.74 years. The mean C-reactive protein level was 9.83±8.29, the mean erythrocyte sedimentation rate was 26.12±16.28 mm/h, and the mean DAS28 was 3.03±0.37. There was a statistically significant increase in the maximum P wave, Pd, maximum QT, QT dispersion, maximum QTc, QTc dispersion, maximum Tp-e, Tp-e dispersion, and Tp-e/QTc dispersion parameters in the RA group compared to the control group, while there was a significant decrease in the minimum P wave, minimum QT, and minimum QTc parameters.
Conclusion: In our study, the Pd, QTc dispersion, Tp-e dispersion, and Tp-e/QTc dispersion values of our patients, which indicate the risk of atrial and ventricular arrhythmia, were found to be significantly higher. This finding suggests that our patients had an increased risk of cardiac morbidity and mortality. Arrhythmias are the likely source of the increase in sudden cardiac death in RA, and these new indicators measured on ECG can be used as standardized cardiovascular morbidity and mortality indicators in the future.
FORMULASI DAN UJI FISIK SEDIAAN SALEP EKSTRAK DAUN JAMBU AIR (Syzygium aqueum (Burm F.) Alston) DENGAN VARIASI TIPE BASIS SALEP
Authors: Permatasari Yunita Dian , Kirani Nava , Nafisah Umi , Dewi Aptika Oktaviana Trisna 
Published: August 2024

Water guava leaves contain chemical compounds such as flavonoids, tannins and saponins. As a medicinal preparation, water guava leaves can be made into an ointment. This study aims to determine the ointment formulation, conduct physical evaluation of the ointment and determine the effect of different types of ointment base extracts of water guava leaves on physical properties. Water guava leaves extract was made by maceration method of ethanol 70% solvent. Ointment are made with four types of bases which include hydrocarbon base, absorption, water washed and water soluble. Each formula was tested for physical properties including organoleptic, homogeneity, pH, dispersal, and adhesion. The data obtained were then analyzed using the One Way ANOVA test method. The results showed that the four ointment formulas had different shapes and colors, had the same odor and had good homogeneity. The pH test of the hydrocarbon bases ointment was 4.09, the absorption bases was 3.98, the water-washed bases was 4.33, and the water-soluble base was 3.87 did not meet the pH test parameters. The dispersibility test results for hydrocarbon bases 6.20 cm, absorption basis 6.19 cm met the test parameters, base ointment was washed with water 3.99 cm, water soluble base 3.49 cm did not meet the dispersibility test parameters. The results of the adhesion test for hydrocarbon bases 11.85, absorption bases 12.11, water washable bases 20.03, and water soluble bases 4.97, which means they meet the adhesion test parameters. The results of the One Way ANOVA test showed that the pH test, spreadability and adhesion had the same significant value, namely 0.000 <0.05. These results indicate that the different types of ointment bases used have a significant effect on pH, dispersion and adhesion.
PEMBUATAN DAN VALIDASI KUESIONER EVALUASI PENERAPAN PERMENKES NOMOR 73 TAHUN 2016 DI APOTEK SWASTA KOTA TARAKAN
Authors: Rukaya Benazir Evita , Syuhada Syuhada , Mustika Tahuti 
Published: August 2024

Standar pelayanan kefarmasian merupakan tolak ukur yang digunakan sebagai pedoman bagi tenaga farmasi dalam penyelenggaraan pelayanan di Apotek. Dimana kualitas pelayanan dapat dievaluasi dan dinilai berdasarkan tingkat kepuasan dari pengguna jasa layanan. Untuk mengukur tingkat kepuasan tentunya membutuhkan instrumen yang valid dan reliabel agar hasil yang diberikan konsisten dan dapat dipercaya. Tujuan dari penelitian ini adalah untuk membuat kuesioner yang relevan dengan Permenkes nomor 73 Tahun 2016 dan tentunya telah diuji validitas dan realibilitasnya. Penelitian ini merupakan penelitian analisis deskritif kualitatif, dengan menggunakan teknik purposive sampling dalam penentuan responden. Penilaian dilakukan dengan membagikan kuesioner kepada 8 responden yang merupakan apoteker. Adapun metode penyebaran kuesioner yang digunakan adalah metode tes ulang atau test-retest-method. Metode tersebut merupakan metode yang dilakukan lebih dari satu kali yaitu hari ke-1, 3 dan 6, menggunakan instrumen yang sama, kemudian hasil dari tes tersebut dikorelasikan menggunakan Software SKALO V.0.4. dan Software SPSS untuk menilai validitas dan realibilitas instrument yang digunakan. Hasil dari uji validitas dan reabilitas kuesioner ini dinyatakan valid dan reliabel dimana berdasarkan pendapat dari 8 responden yang ada juga menyatakan bahwa kuesioner ini relevan dengan Permenkes Nomor 73 Tahun 2016. Sehingga dapat disimpulkan bahwa kuesioner ini dapat menjadi alternatif pilihan untuk dijadikan alat ukur evaluasi pelayanan kefarmasian di Apotek karena telah dinyatakan valid, reliabel dan relevan dengan Permenkes Nomor 73 Tahun 2016.