bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of outcomes following catheter‐based therapy for acute stroke
Authors: Htyte Nay , Parto Parham , Ragbir Shawn , Jaffe Leeor , White Christopher J. 
Published: November 2014

BackgroundTimely reperfusion directly impacts favorable neurologic outcomes in acute ischemic stroke (AIS) patients. Most strokes present outside the 3–4.5 h window for intravenous thrombolysis (IV‐tPA). Catheter‐based therapy (CBT) is commonly used in patients not eligible for timely IV‐tPa, but variables that predict good neurologic outcomes are poorly understood.MethodsResults of 124 consecutive AIS patients who received CBT at Ochsner Medical Center from 2006 and 2012 are reported. A modified Rankin score (mRs) of ≤ 2 at 90 day post‐CBT was used as the primary measurement of a good neurologic outcome. All‐cause mortality during the index hospitalization, ≤30 days from treatment, and at 1 year were reported. Results are reported as those treated by Interventional Cardiologists (IC) or by Neurointerventionalists (NI).ResultsThe mean age was 65 ± 16 years of which 48% (n = 52) were male. The mean NIHSS was 15.0 ± 7.5. Thrombolysis in cerebral infarction (TICI) ≥2 flow was achieved in 80% (n = 100). Good neurologic outcome was observed in 64% (n = 37 of 58) of patients 65 years or younger while in those older than 65, only 36% (n = 24 of 66) had the same outcome (P = 0.002). Mortality at 30 days for the two age groups were 21% (n = 12) vs. 50% (n = 33) (P = <0.001) respectively. A good neurologic outcome at 90 days was seen in 57% of patients with restoration of TICI ≥ 2 flow compared to 17% with TICI < 2 flow (P = <0.001). Those with failed reperfusion (TICI<2 flow) had 30‐day mortality rate of 54% (13 of 24) vs. 20% (19 of 97) in those with TICI ≥ 2 flow (P = <0.001). At 90 days, there was no significant differences in patient outcomes between IC (n = 58) and NI (n = 66) treated patients.ConclusionSuccessful revascularization with CBT leads to a good neurologic outcome in selected stroke patients. Medical co‐morbidities and increased age > 65 years contributed to poor outcomes. To support broadening the number of physicians qualified to perform catheter‐based stroke interventions, this study demonstrates that IC participating on a stroke team achieve comparable outcomes to NI. © 2014 Wiley Periodicals, Inc.
Alternating Donor–Acceptor Arrays from Hexa‐peri‐hexabenzocoronene and Benzothiadiazole: Synthesis, Optical Properties, and Self‐Assembly
Authors: Hinkel Felix , Cho Don , Pisula Wojciech , Baumgarten Martin , Müllen Klaus 
Published: November 2014

AbstractDonor–acceptor (D–A) structures were obtained by alternating arrays of hexa‐peri‐hexabenzocoronene (HBC) and benzo[c][1,2,5]thiadiazole (BTZ). Optoelectronic investigations revealed a charge transfer due to strong push–pull interactions. 2 D wide‐angle X‐ray scattering (WAXS) data indicated an arrangement in liquid‐crystalline columnar assemblies, in which the π‐stacking distances and molecular orientation depend on the number of HBC units in the molecules.
4‐Aryl‐3,5‐bis(arylethynyl)aryl‐4H‐1,2,4‐triazoles: Multitasking Skeleton as a Self‐Assembling Unit
Authors: Pastor M. Jesús , Torres Iván , Cebrián Cristina , Carrillo José Ramón , Díaz‐Ortiz Ángel , Matesanz Emilio , Buendía Julia , García Fátima , Barberá Joaquín , Prieto Pilar , Sánchez Luis 
Published: November 2014

AbstractThe synthesis of a series of 4‐aryl‐3,5‐bis(arylethynyl)aryl‐4H‐1,2,4‐triazoles derivatives is reported and the influence exerted by peripheral substitution on the morphology of the aggregates generated from these 1,2,4‐triazoles is investigated by SEM imaging. The presence of paraffinic side chains results in long fibrillar supramolecular structures, but unsubstituted triazoles self‐assemble into thinner ribbons and needle‐like aggregates. The crystals obtained from methoxy‐substituted triazoles have been utilised to elaborate a model that helps to justify aggregation of the investigated 1,2,4‐triazoles, in which the operation of arrays of CH⋅⋅⋅π non‐covalent interactions plays a significant role. The results presented herein demonstrate the ability of simple molecules to behave as multitasking scaffolds with different properties, depending on peripheral substitution. Thus, although 1,2,4‐triazoles without long paraffinic side chains exhibit optical waveguiding behaviour, triazoles endowed with peripheral paraffinic side chains exhibit hexagonal columnar mesomorphism.
Substituent and Solvent Effects on the Excited State Deactivation Channels in Anils and Boranils
Authors: Dobkowski Jacek , Wnuk Paweł , Buczyńska Joanna , Pszona Maria , Orzanowska Grażyna , Frath Denis , Ulrich Gilles , Massue Julien , Mosquera‐Vázquez Sandra , Vauthey Eric , Radzewicz Czesław , Ziessel Raymond , Waluk Jacek 
Published: November 2014

AbstractDifferently substituted anils (Schiff bases) and their boranil counterparts lacking the proton‐transfer functionality have been studied using stationary and femtosecond time‐resolved absorption, fluorescence, and IR techniques, combined with quantum mechanical modelling. Dual fluorescence observed in anils was attributed to excited state intramolecular proton transfer. The rate of this process varies upon changing solvent polarity. In the nitro‐substituted anil, proton translocation is accompanied by intramolecular electron transfer coupled with twisting of the nitrophenyl group. The same type of structure is responsible for the emission of the corresponding boranil. A general model was proposed to explain different photophysical responses to different substitution patterns in anils and boranils. It is based on the analysis of changes in the lengths of CN and CC bonds linking the phenyl moieties. The model allows predicting the contributions of different channels that involve torsional dynamics to excited state depopulation.
Aminocatalysis: Beyond Steric Shielding and Hydrogen‐Bonding
Authors: Matos Paz Bruno , Jiang Hao , Jørgensen Karl Anker 
Published: November 2014

AbstractThe stereochemical outcome of most aminocatalytic transformations is determined by the steric‐shielding or hydrogen‐directing approach. However, in recent years several reactions have appeared in which the stereochemical outcome is beyond these two approaches. This Concept article will highlight such reactions and postulate that the stereochemical outcome can be accounted for by electrostatic interactions between the catalyst‐bound substrate and the reagent in the transition state.
Highly Enantioselective Hydrogenation of N‐Aryl Imines Derived from Acetophenones by Using Ru–Pybox Complexes under Hydrogenation or Transfer Hydrogenation Conditions in Isopropanol
Authors: Menéndez‐Pedregal Estefanía , Vaquero Mónica , Lastra Elena , Gamasa Pilar , Pizzano Antonio 
Published: November 2014

AbstractThe asymmetric reduction of N‐aryl imines derived from acetophenones by using Ru complexes bearing both a pybox (2,6‐bis(oxazoline)pyridine) and a monodentate phosphite ligand has been described. The catalysts show good activity with a diverse range of substrates, and deliver the amine products in very high levels of enantioselectivity (up to 99 %) under both hydrogenation and transfer hydrogenation conditions in isopropanol. From deuteration studies, a very different labeling is observed under hydrogenation and transfer hydrogenation conditions, which demonstrates the different nature of the hydrogen source in both reactions.
Reaction of an N‐Heterocyclic Carbene‐Stabilized Silicon(II) Monohydride with Alkynes: [2+2+1] Cycloaddition versus Hydrogen Abstraction
Authors: Eisenhut Carsten , Szilvási Tibor , Breit Nora C. , Inoue Shigeyoshi 
Published: November 2014

AbstractAn in depth study of the reactivity of an N‐heterocyclic carbene (NHC)‐stabilized silylene monohydride with alkynes is reported. The reaction of silylene monohydride 1, tBu3Si(H)Si←NHC, with diphenylacetylene afforded silole 2, tBu3Si(H)Si(C4Ph4). The density functional theory (DFT) calculations for the reaction mechanism of the [2+2+1] cycloaddition revealed that the NHC played a major part stabilizing zwitterionic transition states and intermediates to assist the cyclization pathway. A significantly different outcome was observed, when silylene monohydride 1 was treated with phenylacetylene, which gave rise to supersilyl substituted 1‐alkenyl‐1‐alkynylsilane 3, tBu3Si(H)Si(CHCHPh)(CCPh). Mechanistic investigations using an isotope labelling technique and DFT calculations suggest that this reaction occurs through a similar zwitterionic intermediate and subsequent hydrogen abstraction from a second molecule of phenylacetylene.
Long‐Lived Excited States of Zwitterionic Copper(I) Complexes for Photoinduced Cross‐Dehydrogenative Coupling Reactions
Authors: Wang Bin , Shelar Deepak Prakash , Han Xian‐Zhu , Li Ting‐Ting , Guan Xiangguo , Lu Wei , Liu Kun , Chen Yong , Fu Wen‐Fu , Che Chi‐Ming 
Published: November 2014

AbstractFour heteroleptic copper(I) complexes containing phenanthroline and monoanionic nido‐carborane‐diphosphine ligands have been prepared and structurally characterized by various spectroscopic techniques and X‐ray diffraction. These complexes exhibit intense absorptions in the visible range and excited‐state lifetimes on the microsecond scale. Their application in visible‐light‐induced cross‐dehydrogenative coupling reactions was investigated. Preliminary studies showed that one of the four copper(I) complexes is an efficient catalyst for photoinduced oxidative CH functionalization using oxygen as oxidant. Furthermore, α‐functionalized tertiary amines were obtained in good‐to‐excellent yields by light irradiation (λ>420 nm) of a mixture of our CuI complex, tertiary amines, and a variety of nucleophiles (nitroalkane, acetone, or indoles) under aerobic conditions. Electron paramagnetic resonance measurements provided evidence for the formation of superoxide radical anions (O2−⋅) rather than singlet oxygen (1O2) during these photocatalytic reactions.
Graphitic Carbon Nitride Polymer as a Recyclable Photoredox Catalyst for Fluoroalkylation of Arenes
Authors: Baar Moritz , Blechert Siegfried 
Published: November 2014

AbstractHeterogeneous catalysis for trifluoromethylations and perfluoroalkylations has been performed. Through the usage of cheap, metal‐free and recyclable mesoporous graphitic carbon nitride (mpg‐CN) it was possible to fluoroalkylate various arenes by the reductive activation of sulfonyl chlorides with visible light. Thus, we were able to demonstrate the robustness and versatility of mpg‐CN as a photoredox catalyst beyond water splitting and the activation of oxygen.
ChemInform Abstract: Current Perspective on Bacterial Pigments: Emerging Sustainable Compounds with Coloring and Biological Properties for the Industry — An Incisive Evaluation
Authors: Venil Chidambaram Kulandaisamy , Aruldass Claira Arul , Dufosse Laurent , Zakaria Zainul Akmar , Ahmad Wan Azlina 
Published: November 2014

AbstractReview: 52 refs.
Quality of life over 5 years after a breast cancer diagnosis among low‐income women: Effects of race/ethnicity and patient‐physician communication
Authors: Maly Rose C. , Liu Yihang , Liang Li‐Jung , Ganz Patricia A. 
Published: November 2014

BACKGROUNDThe current study was performed to identify risk factors for a lower quality of life (QOL) among low‐income women with breast cancer (BC), with an emphasis on the impact of patient‐physician communication. In addition, ethnic/racial group differences in QOL changes over time were examined.METHODSA longitudinal study was conducted among 921 low‐income women with BC. Patients were interviewed at 6 months, 18 months, 36 months, and 60 months after their diagnosis of BC. Mixed‐effect regression models were performed to investigate predictors for and time effects on QOL. The main outcomes included the Medical Outcomes Study Health Survey Short Form‐36 Mental Component Summary scale (SF‐36 MCS), Medical Outcomes Study Health Survey Short Form‐36 Physical Component Summary scale (SF‐36 PCS), and the Ladder of Life scale. Chief independent variables included physician information‐giving and patient self‐efficacy in interacting with physicians.RESULTSThere were no significant changes noted over time in QOL except with regard to physical functioning, with survivors reporting a significant decrease over time (P<.0001). Mean SF‐36 MCS and SF‐36 PCS scores were lower than national general population norms at all time points. Both patient self‐efficacy in interacting with physicians and physician information‐giving were found to be positively associated with the SF‐36 MCS (P = .03 and P = .02, respectively) and Ladder of Life (P = .01 and P = .03, respectively) scales. Latinas who were less acculturated reported higher SF‐36 MCS and SF‐36 PCS scores (P<.0001 and P = .01, respectively) and better global QOL (P<.0001) than white women.CONCLUSIONSLow‐income women with BC experienced poor physical and mental health. The results of the current study suggest that QOL among low‐income women with BC would be enhanced by interventions aimed at empowering patients in communicating with physicians and increasing the amount of information provided by physicians. Cancer 2015;121:916–926. © 2014 American Cancer Society.
Modeling of Structural, Energetic, and Dynamic Properties of Few‐Atom Silver Clusters Embedded in Polynucleotide Strands by Using Molecular Dynamics
Authors: Staelens Nicolas , Leherte Laurence , Champagne Benoît , Vercauteren Daniel P. 
Published: November 2014

AbstractThis work concerns the study of the structural, energetic, and dynamic properties of fluorescent systems composed of silver clusters stabilized by polynucleotide strands. To do so, classical interaction potentials relative to silver, neutral and cationic, were introduced in the AMBER force field. Molecular dynamics simulations allowed analysis of the nature and force of the interactions between the various parts of the nucleic oligomers and the silver clusters. Conformational analyses were necessary to explore the flexibility of the supramolecular assemblies, specifically by radial distribution functions and Ramachandran‐type maps.
Non‐Ideal Mixing Behaviour of Hydrogen Bonding in Mixtures of Protic Ionic Liquids
Authors: Fumino Koichi , Bonsa Anne‐Marie , Golub Benjamin , Paschek Dietmar , Ludwig Ralf 
Published: November 2014

AbstractIonic liquids (ILs) attract interest in science and technology as a result of their unique properties. Binary and ternary mixtures of ILs significantly increase the number of possible cation/anion combinations, resulting in targeted physical and chemical properties. In this work, we study the mixing behaviour of two protic ILs: triethyl ammonium methylsulfonate [Et3NH][CH3SO3] and triethylammonium triflate [Et3NH][CF3SO3]. We find a characteristic deviation from ideal mixing by means of low‐frequency infrared spectroscopy. By using molecular dynamics simulations, we explain this behaviour as being the result of different strengths of anion/cation hydrogen bonding. This non‐ideality of non‐random H‐bond mixing is also reflected in macroscopic properties such as the viscosity. Mixing suitable ILs may, thus, result in new ILs with targeted physical properties.
Motion‐Based, High‐Yielding, and Fast Separation of Different Charged Organics in Water
Authors: Xuan Mingjun , Lin Xiankun , Shao Jingxin , Dai Luru , He Qiang 
Published: November 2014

AbstractWe report a self‐propelled Janus silica micromotor as a motion‐based analytical method for achieving fast target separation of polyelectrolyte microcapsules, enriching different charged organics with low molecular weights in water. The self‐propelled Janus silica micromotor catalytically decomposes a hydrogen peroxide fuel and moves along the direction of the catalyst face at a speed of 126.3 μm s−1. Biotin‐functionalized Janus micromotors can specifically capture and rapidly transport streptavidin‐modified polyelectrolyte multilayer capsules, which could effectively enrich and separate different charged organics in water. The interior of the polyelectrolyte multilayer microcapsules were filled with a strong charged polyelectrolyte, and thus a Donnan equilibrium is favorable between the inner solution within the capsules and the bulk solution to entrap oppositely charged organics in water. The integration of these self‐propelled Janus silica micromotors and polyelectrolyte multilayer capsules into a lab‐on‐chip device that enables the separation and analysis of charged organics could be attractive for a diverse range of applications.
Retracted: A Naphthalenediimide‐Based Fluorescent Sensor for Detecting the pH within the Rough Endoplasmic Reticulum of Living Cells
Authors: Ghule Namdev V. , Bhosale Rajesh S. , Kharat Kiran , Puyad Avinash L. , Bhosale Sheshanath V. , Bhosale Sidhanath V. 
Published: November 2014

AbstractAn amino‐core‐substituted naphthalenediimide (NDI) derivative has been synthesized in good yield in two steps. The NDI bearing a diamine moiety undergoes a reversible protonation–deprotonation process, which results in intensity changes in the absorption and emission spectra. This derivative exhibits good photostability, good selectivity, high sensitivity, and is employed to exhibit the pH within the rough endoplasmic reticulum of living cells.
A New Class of Single‐Component Absorbents for Reversible Carbon Dioxide Capture under Mild Conditions
Authors: Barzagli Francesco , Lai Sarah , Mani Fabrizio 
Published: November 2014

AbstractSome inexpensive and commercially available secondary amines reversibly react with CO2 at room temperature and ambient pressure to yield carbonated species in the liquid phase in the absence of any additional solvent. These solvent‐free absorbents have a high CO2 capture capacity (0.63–0.65 mol CO2/mol amine) at 1.0 bar (=100 kPa), combined with low‐temperature reversibility at ambient pressure. 13C NMR spectroscopy analysis identified the carbonated species as the carbamate salts and unexpected carbamic acids. These absorbents were used for CO2 (15 and 40 % in air) capture in continuous cycles of absorption–desorption carried out in packed columns, yielding an absorption efficiency of up to 98.5 % at absorption temperatures of 40–45 °C and desorption temperatures of 70–85 °C at ambient pressure. The absence of any parasitic solvent that requires to be heated and stability towards moisture and heating could result in some of these solvent‐free absorbents being a viable alternative to aqueous amines for CO2 chemical capture.
Selective Modulation of Charge‐Carrier Transport of a Photoanode in a Photoelectrochemical Cell by a Graphitized Fullerene Interfacial Layer
Authors: Park Sun‐Young , Lim Dong Chan , Hong Eun Mi , Lee Joo‐Yeoul , Heo Jinhee , Lim Jae Hong , Lee Chang‐Lyoul , Kim Young Dok , Mul Guido 
Published: November 2014

AbstractWe show that a graphitic carbon interfacial layer, derived from C70 by annealing at 500 °C, results in a significant increase in the attainable photocurrent of a photoelectrochemical cell that contains a WO3‐functionalized fluorine‐doped tin oxide (FTO) photoanode. Time‐resolved photoluminescence spectroscopy, photoconductive atomic force microscopy, Hall measurements, and electrochemical impedance spectroscopy show that the increase in photocurrent is the result of fast and selective electron transport from optically excited WO3 through the graphitic carbon interfacial layer to the FTO‐coated glass electrode. Thus the energy efficiency of perspective solar‐to‐fuel devices can be improved by modification of the interface of semiconductors and conducting substrate electrodes by using graphitized fullerene derivatives.
Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells
Authors: Richter Constanze , Viergutz Torsten , Schwerin Manfred , Weitzel Joachim M. 
Published: November 2014

AbstractExposure to heat stress in dairy cows leads to undesired side effects that are reflected by complex alterations in endocrine parameters, such as reduced progesterone, estradiol, and thyroid hormone concentrations. These endocrine maladaptation leads to failure to resume cyclicity, a poor uterine environment and inappropriate immune responses in postpartum dairy cows. Prostaglandins (PG's) are lipid mediators, which serve as signal molecules in response to various external stimuli as well as to cell‐specific internal signal molecules. A central role in PG synthesis plays prostaglandin E synthase (PGES) that catalyzes the isomerization of PGH2 to PGE2.The present study was conducted to investigate heat stress associated PGES expression. Expression of PGES and inducible heat shock protein 70 (HSP70), as a putative chaperonic protein, was studied in bovine primary fibroblasts under different heat shock conditions. Bovine primary fibroblasts produce PGE2 at homoiothermical norm temperature (38.5°C in bovine), but reduce PGE2 production rates under extreme heat stress (at 45°C for 6 h). By contrast, PGE2 production rates are maintained after a milder heat stress (at 41.5°C for 6 h). PGE2 synthesis is abolished by application of cyclooxygenase inhibitor indomethacin, indicating de novo synthesis. Heat stress increases HSP70 but not PGES protein concentrations. HSP70 physically interacts with PGES and the PGES‐HSP70 complex did not dissociate upon heat stress at 45°C even after returning the cells to 37°C. The PGE2 production negatively correlates with the portion of PGES‐HSP70 complex. These results suggest a protein interaction between HSP70 and PGES in dermal fibroblast cells. Blockage of PGES protein by HSP70 seems to interfere with the regulatory processes essential for cellular adaptive protection. © 2014 International Society for Advancement of Cytometry
Nest destruction elicits indiscriminate con‐ versus heterospecific brood parasitism in a captive bird
Authors: Shaw Rachael C. , Feeney William E. , Hauber Mark E. 
Published: November 2014

AbstractFollowing nest destruction, the laying of physiologically committed eggs (eggs that are ovulated, yolked, and making their way through the oviduct) in the nests of other birds is considered a viable pathway for the evolution of obligate interspecific brood parasitism. While intraspecific brood parasitism in response to nest predation has been experimentally demonstrated, this pathway has yet to be evaluated in an interspecific context. We studied patterns of egg laying following experimental nest destruction in captive zebra finches, Taeniopygia guttata, a frequent intraspecific brood parasite. We found that zebra finches laid physiologically committed eggs indiscriminately between nests containing conspecific eggs and nests containing heterospecific eggs (of Bengalese finches, Lonchura striata vars. domestica), despite the con‐ and heterospecific eggs differing in both size and coloration. This is the first experimental evidence that nest destruction may provide a pathway for the evolution of interspecific brood parasitism in birds.