bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Lupus Nephritis With Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study
Authors:   The ACCESS Trial Group
Published: August 2014

ObjectiveTo assess the efficacy and safety of a 24‐week course of abatacept in the treatment of active lupus nephritis and to assess the potential of abatacept to induce “clinical tolerance,” defined as sustained clinical quiescence of lupus nephritis after discontinuation of immunosuppressive therapy.MethodsPatients with active lupus nephritis (n = 134) were enrolled in a randomized, double‐blind phase II add‐on trial in which they received either abatacept or placebo in conjunction with the Euro‐Lupus Nephritis Trial regimen of low‐dose cyclophosphamide (CYC) followed by azathioprine (AZA). The primary efficacy outcome was the frequency of complete response at week 24. Thereafter, patients who met either complete or partial response criteria continued blinded treatment through week 52. During this phase of the study, subjects in the abatacept treatment group in whom a complete response was achieved at week 24 discontinued immunosuppressive therapy other than prednisone (10 mg/day).ResultsThere were no statistically significant differences between groups with respect to the primary outcome or any of the secondary outcomes, including measures of safety. A complete response was achieved in 33% of the subjects in the treatment group and in 31% of the subjects in the control group at week 24. Fifty percent of the subjects in the treatment group who met complete response criteria and therefore discontinued immunosuppressive therapy at week 24 maintained their complete response status through week 52.ConclusionThe addition of abatacept to a regimen of CYC followed by AZA did not improve the outcome of lupus nephritis at either 24 or 52 weeks. No worrisome safety signals were encountered.
Feeding strategies enhance high cell density cultivation and protein expression in milliliter scale bioreactors
Authors: Faust Georg , Janzen Nils H. , Bendig Christoph , Römer Lin , Kaufmann Klaus , Weuster‐Botz Dirk 
Published: August 2014

AbstractMiniature bioreactors under parallel fed‐batch operations are not only useful screening tools for bioprocess development but also provide a suitable basis for eventual scale‐up. In this study, three feeding strategies were investigated: besides the established intermittent feeding by a liquid handler, an optimized microfluidic device and a new enzymatic release system were applied for parallel fed‐batch cultivation of Escherichia coli HMS174(DE3) and BL21(DE3) strains in stirred‐tank bioreactors on a 10 mL scale. Lower fluctuation in dissolved oxygen (DO) and higher optical densities were measured in fed‐batch processes applying the microfluidic device or the enzymatic glucose/fructose release system (conversion of intermittently added sucrose by an invertase), but no difference in dry cell weights (DCW) were observed. With all three feeding strategies high cell densities were realized on a milliliter scale with final optical density measured at 600 nm (OD600) of 114–133 and final DCW concentrations of 69–70 g L–1. The effect of feeding strategies on the expression of two heterologous proteins was investigated. Whereas no impact was observed on the expression of the spider silk protein eADF4(C16), the fluorescence of enhanced green fluorescence protein (eGFP) was reproducibly lower, if an intermittent glucose feed was applied. Thus, the impact of feeding strategy on expression is strongly dependent on the E. coli strain and/or expressed protein. As a completely continuous feed supply is difficult to realize in miniature bioreactors, the enzymatic release approach from this study can be easily applied in all microfluidic system to reduce fluctuations of glucose supply and DO concentrations.
ChemInform Abstract: Thermoelectric Properties, Crystal and Electronic Structure of Semiconducting RECuSe2 (RE: Pr, Sm, Gd, Dy and Er).
Authors: Esmaeili Mehdi , Tseng Yu‐Chih , Mozharivskyj Yurij 
Published: August 2014

AbstractThe title compounds are prepared from the elements (silica tubes, 600—800 °C, 300 h) and characterized by powder and single crystal XRD, electrical resistivity and Seebeck coefficient measurements, and TB‐LMTO‐ASA electronic band structure calculations.
ChemInform Abstract: Crystal Structure and Magnetic Properties of Ln3Mn0.5GeS7 (Ln: Y, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho and Er).
Authors: Daszkiewicz M. , Marchuk O. V. , Gulay L. D. , Kaczorowski D. 
Published: August 2014

AbstractThe title compounds are prepared from the elements (1150 °C, 3 h, annealing at 500 °C for 720 h) and characterized by single crystal XRD and magnetic measurements.
ChemInform Abstract: (C5H6N)4 [Be6(HPO3)8]·H2O: A Low‐Density Open‐Framework Beryllium Phosphite with Multidirectional 12‐Ring Channels.
Authors: Wang Guo‐Ming , Li Jin‐Hua , Zhang Xiao , Jiang Wen‐Wen , Bao Zhen‐Zhen , Zhao Xiao‐Meng , Wang Ying‐Xia , Lin Jian‐Hua 
Published: August 2014

AbstractColorless rod‐like crystals of the new three‐dimensional open‐framework beryllium phosphite (pyH)4 [Be6(HPO3)8]·H2O are solvothermally synthesized from a mixture of BeSO4, H3PO3, pyridine, and H2O (autoclave, 160 °C, 6 d, 77% yield).
ChemInform Abstract: In[IO3](OH)2 — New Member of Hydrous and Anhydrous Iodate Family with Indium.
Authors: Belokoneva E. L. , Dimitrova O. V. , Volkov A. S. 
Published: August 2014

AbstractIn[IO3](OH)2 single crystals are hydrothermally prepared from In(NO3)3, KIO3, K2CO3, and H3BO3 (autoclave, 270 °C, ≈70 bar, 18—20 d).
ChemInform Abstract: Zinc‐Catalyzed Direct Cyanation of Indoles and Pyrroles: Nitromethane as a Source of a Cyano Group.
Authors: Nagase Yuta , Sugiyama Tetsuya , Nomiyama Shota , Yonekura Kyohei , Tsuchimoto Teruhisa 
Published: August 2014

AbstractThe use of nitromethane as CN‐source for the direct cyanation of indoles and pyrroles is demonstrated.
ChemInform Abstract: Peptide‐Nanofiber‐Supported Palladium Nanoparticles as an Efficient Catalyst for the Removal of N‐Terminus Protecting Groups.
Authors: Maity Indrajit , Manna Manoj K. , Rasale Dnyaneshwar B. , Das Apurba K. 
Published: August 2014

AbstractPeptide‐based bolaamphiphile nanofibers are synthesized and used to stabilize Pd‐nanoparticles.
ChemInform Abstract: Catalytic C—H α‐Trifluoromethylation of α,β‐Unsaturated Carbonyl Compounds.
Authors: Fang Zhongxue , Ning Yongquan , Mi Pengbing , Liao Peiqiu , Bi Xihe 
Published: August 2014

AbstractApplication of this method is demonstrated by the trifluoromethylation of several bioactive drugs.
ChemInform Abstract: A Direct Copper‐Promoted Three‐Component Entry to Trifluoromethylketoximes.
Authors: Wang Shuai , Nie Jing , Zheng Yan , Ma Jun‐An 
Published: August 2014

AbstractUse of other electron‐rich arenes such as N,N‐dimethylaniline and 3‐dimethylaminoanisole does not deliver the desired products.
ChemInform Abstract: Iron(II) Complexes Containing Unsymmetrical P—N—P′ Pincer Ligands for the Catalytic Asymmetric Hydrogenation of Ketones and Imines.
Authors: Lagaditis Paraskevi O. , Sues Peter E. , Sonnenberg Jessica F. , Wan Kai Yang , Lough Alan J. , Morris Robert H. 
Published: August 2014

AbstractThe designed title complexes are successfully applied in the reduction of several aliphatic and aromatic substituted ketones and imines with moderate to high enantioselectivities.
ChemInform Abstract: An Efficient Palladium‐Catalyzed Synthesis of Cinnamyl Ethers from Aromatic Halides, Phenols, and Allylic Chloride.
Authors: Wang Wei , Zhou Rong , Jiang Zhi‐Jie , Wang Kun , Fu Hai‐Yan , Zheng Xue‐Li , Chen Hua , Li Rui‐Xiang 
Published: August 2014

AbstractThe use of iodonaphtalene (IX) as arylating agent affords the corresponding enol ether (X) instead of allyl aryl ethers.
ChemInform Abstract: Palladium/Copper‐Catalyzed Oxidative Arylation of Terminal Alkenes with Aroyl Hydrazides.
Authors: Zhang Yong‐Gang , Liu Xiang‐Lei , He Zeng‐Yang , Li Xi‐Ming , Kang Hong‐Jian , Tian Shi‐Kai 
Published: August 2014

AbstractFor the first time, the oxidative Mizoroki‐Heck reaction of terminal alkenes using aroyl hydrazides is reported.
ChemInform Abstract: Proton‐Exchanged Montmorillonite‐Mediated Reactions of Methoxybenzyl Esters and Ethers.
Authors: Chen Dongyin , Xu Chang , Deng Jie , Jiang Chunhuan , Wen Xiaoan , Kong Lingyi , Zhang Ji , Sun Hongbin 
Published: August 2014

AbstractThe operationally simple protocol allows the Friedel‐Crafts‐like alkylation of arenes and heteroarenes, as well as the etherification of a variety of alcohols with benzyl acetates.
ChemInform Abstract: Synthesis of 2,5‐Diaryl‐Substituted Thiophenes as Helical Mimetics: Towards the Modulation of Islet Amyloid Polypeptide (IAPP) Amyloid Fibril Formation and Cytotoxicity.
Authors: Hassanpour Avid , De Carufel Carole Anne , Bourgault Steve , Forgione Pat 
Published: August 2014

AbstractAll products are investigated for their capacity of modulating IAPP amyloid fibril formation with the thioflavin T fluorescence‐based assay.
ChemInform Abstract: Synthesis of Chlorophyll Derivatives Possessing a Mono/Bi/Terpyridinyl Group at the C3‐Ethynyl Terminal and Optical Properties of the π‐Conjugates.
Authors: Yamamoto Youhei , Tamiaki Hitoshi 
Published: August 2014

AbstractThe synthesis of eight of the title compounds is presented (three examples are shown in the scheme).
ChemInform Abstract: Synthesis of New Fluorescent Building Blocks via the Microwave‐Assisted Annulation Reaction of 1,1,2‐Trimethyl‐1H‐benzo[e]indole with Acrylic Acid and Its Derivatives.
Authors: Steponaviciute Rasa , Martynaitis Vytas , Bieliauskas Aurimas , Sackus Algirdas 
Published: August 2014

AbstractThe title reaction gives access to benzo[e]pyrido[1.2‐α]indole derivatives, which bear reactive enaminone or enamide functionalities that can be used in several further transformations.
ChemInform Abstract: Preparation of 3,5‐Disubstituted Pyrazoles and Isoxazoles from Terminal Alkynes, Aldehydes, Hydrazines, and Hydroxylamine.
Authors: Harigae Ryo , Moriyama Katsuhiko , Togo Hideo 
Published: August 2014

AbstractA simple and practical one‐pot method for the highly regioselective synthesis of 3,5‐disubstituted pyrazoles [e.g. (III), (V), and (VII)], isoxazoles [e.g. (XII), (XIV), and (XV)] from easily available compounds is presented.
ChemInform Abstract: Ligand Promoted Pd‐Catalyzed Dehydrogenative Alkenylation of Hetereoarenes.
Authors: Lee Wei‐Chih , Wang Ting‐Hsuan , Ong Tiow‐Gan 
Published: August 2014

AbstractPractical feasibility of the approach can be demonstrated in the total synthesis of the natural products Annuloline and Siphonazole.
ChemInform Abstract: Substitution Controlled Functionalization of ortho‐Bromobenzylic Alcohols via Palladium Catalysis: Synthesis of Chromenes and Indenols.
Authors: Mahendar Lodi , Satyanarayana Gedu 
Published: August 2014

AbstractAn efficient domino method for the conversion of simple ortho‐bromobenzylic tertiary alcohols to chromenes (II) and (IV) is developed.
ChemInform Abstract: A New Access to 1,8‐Dioxooctahydroxanthenes Using Yttrium(III) Nitrate Hexahydrate and Tin(II) Chloride Dihydrate as Effective and Reusable Catalysts.
Authors: Karami B. , Eskandari K. , Zare Z. , Gholipour S. 
Published: August 2014

AbstractY(NO3)3 as well as SnCl2 appear to be efficient catalysts for the synthesis of xanthene derivatives such as (III) and (V) via condensation of a wide range of aryl aldehydes and cyclohexane‐1,3‐diones.
ChemInform Abstract: Gold‐Catalyzed Redox Synthesis of Imidazo[1,2‐a]pyridines Using Pyridine N‐Oxide and Alkynes.
Authors: Talbot Eric P. A. , Richardson Melodie , McKenna Jeffrey M. , Toste F. Dean 
Published: August 2014

AbstractThe reaction is sensitive to the steric effects and does not tolerate tBu‐ or mesityl‐substituents.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed [3 + 4] Cycloaddition and Kinetic Resolution of Azomethine Imines.
Authors: Wang Ming , Huang Zhijian , Xu Jianfeng , Chi Yonggui Robin 
Published: August 2014

AbstractA highly diastereoselective and enantioselective NHC‐catalyzed oxidative cycloaddition of several 2,3‐unsaturated aldehydes to a variety of the title compounds to obtain fused seven‐membered heterocyclic products is presented.
ChemInform Abstract: Metal‐Catalyzed [6 + 3] Cycloaddition of Tropone with Azomethine Ylides: A Practical Access to Piperidine‐Fused Bicyclic Heterocycles.
Authors: Guo Hongchao , et al. et al. 
Published: August 2014

AbstractThe first metal‐catalyzed [6+3] cycloaddition of tropone with azomethine ylides is reported.
ChemInform Abstract: Sterically Directed Iridium‐Catalyzed Hydrosilylation of Alkenes in the Presence of Alkynes.
Authors: Muchnij Jill A. , Kwaramba Farai B. , Rahaim Ronald J. 
Published: August 2014

AbstractIn analogy to the hydrosilylation of (Ia), conversion of (Ib) with phenylacetylene or 4‐trifluoromethylphenylacetylene yields only the product of anti‐Markovnikov addition.
ChemInform Abstract: Diverted Total Synthesis of Falcitidin Acyl Tetrapeptides as New Antimalarial Leads.
Authors: Kotturi Santosh R. , Somanadhan Brinda , Ch'ng Jun‐Hong , Tan Kevin S.‐W. , Butler Mark S. , Lear Martin J. 
Published: August 2014

AbstractThe total syntheses of antimalarial agent Falcitidin (I) as well as related N‐acyl analogues (II) are outlined and the efficiency of the latter compounds against chloroquine‐sensitive Plasmodium falciparum 3D7 is tested.
ChemInform Abstract: Total Syntheses of (‐)‐Pyrimidoblamic Acid and P‐3A.
Authors: Duerfeldt Adam S. , Boger Dale L. 
Published: August 2014

AbstractKey step of the synthesis of the title compounds is an inverse electron demand Diels↔Alder reaction between substituted electron‐deficient 1,2,3‐triazines and a highly functionalized and chiral primary amidine, which forms the pyrimidine cores and introduces all necessary stereochemistry in a single step.
Health‐related quality of life as a prognostic factor in patients with advanced cancer
Authors: Steel Jennifer L. , Geller David A. , Robinson Tiana L. , Savkova Alexandra Y. , Brower Deborah S. , Marsh J. Wallis , Tsung Allan 
Published: August 2014

BACKGROUNDEvidence continues to accumulate regarding the association between health‐related quality of life (HRQoL) and survival across chronic diseases. The objectives of the current study were to investigate the prognostic value of HRQoL in patients with hepatocellular carcinoma and cholangiocarcinoma after adjusting for sociodemographics, disease‐related factors, and treatment‐related factors.METHODSA total of 321 patients diagnosed with hepatocellular or cholangiocarcinoma were administered the Functional Assessment of Cancer Therapy‐Hepatobiliary instrument. Cox regression and Kaplan‐Meier survival analyses were performed to test the association between the 5 domains of HRQoL and survival.RESULTSUsing Cox regression, overall HRQoL was found to be significantly associated with survival (P = .003) after adjusting for demographics, disease‐specific factors, and treatment. Subscales of the Functional Assessment of Cancer Therapy‐Hepatobiliary, including the Physical Well‐Being (P = .02) and the Symptoms and Side Effects subscales (P = .05), were also found to be significantly associated with survival after adjusting for demographics, disease‐specific factors, and treatment.CONCLUSIONSHRQoL was found to be prognostic of survival in patients with hepatocellular and cholangiocarcinoma while covarying for demographics, disease‐specific factors, and treatment. Stratifying patients based on HRQoL when testing novel treatments may be recommended.Health‐related quality of life was found to be prognostic of survival in patients with hepatocellular and cholangiocarcinoma while controlling for demographics, disease‐specific factors, and treatment‐related factors. Cancer 2014;120:3717–3721. © 2014 American Cancer Society.
Agent Orange exposure and cancer incidence in Korean Vietnam veterans: A prospective cohort study
Authors: Yi Sang‐Wook , Ohrr Heechoul 
Published: August 2014

BACKGROUNDDuring the Vietnam War, US and allied military sprayed approximately 77 million liters of tactical herbicides including Agent Orange, contaminated with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. To the authors' knowledge, few studies to date have examined the association between Agent Orange exposure and cancer incidence among Korean veterans who were exposed to Agent Orange during the Vietnam War.METHODSAn Agent Orange exposure index, based on the proximity of the veteran's military unit to the area that was sprayed with Agent Orange, was developed using a geographic information system‐based model. Cancer incidence was followed for 180,251 Vietnam veterans from 1992 through 2003.RESULTSAfter adjustment for age and military rank, high exposure to Agent Orange was found to significantly increase the risk of all cancers combined (adjusted hazards ratio [aHR], 1.08). Risks for cancers of the mouth (aHR, 2.54), salivary glands (aHR, 6.96), stomach (aHR, 1.14), and small intestine (aHR, 2.30) were found to be significantly higher in the high‐exposure group compared with the low‐exposure group. Risks for cancers of all sites combined (aHR, 1.02) and for cancers of the salivary glands (aHR, 1.47), stomach (aHR, 1.03), small intestine (aHR, 1.24), and liver (aHR, 1.02) were elevated with a 1‐unit increase in the exposure index.CONCLUSIONSExposure to Agent Orange several decades earlier may increase the risk of cancers in all sites combined, as well as several specific cancers, among Korean veterans of the Vietnam War, including some cancers that were not found to be clearly associated with exposure to Agent Orange in previous cohort studies primarily based on Western populations. Cancer 2014;120:3699–3706. © 2014 American Cancer Society.
Monitoring of epidermal growth factor receptor tyrosine kinase inhibitor‐sensitizing and resistance mutations in the plasma DNA of patients with advanced non–small cell lung cancer during treatment with erlotinib
Authors: Sorensen Boe S. , Wu Lin , Wei Wen , Tsai Julie , Weber Britta , Nexo Ebba , Meldgaard Peter 
Published: August 2014

BACKGROUNDThe feasibility of monitoring epidermal growth factor receptor (EGFR) mutations in plasma DNA from patients with advanced non–small cell lung cancer (NSCLC) during treatment with erlotinib and its relation to disease progression was investigated.METHODSThe amount of EGFR‐mutant DNA was tested in plasma DNA from patients with advanced NSCLC with allele‐specific polymerase chain reaction assays. Blood samples from 23 patients with adenocarcinoma of NSCLC that carried tyrosine kinase inhibitor‐sensitizing EGFR mutations were taken immediately before treatment with erlotinib. Additional blood samples were taken at timed intervals until erlotinib treatment was withdrawn.RESULTSThe amount of plasma DNA with sensitizing EGFR mutations was found to be reduced after the first cycle of erlotinib treatment in 22 of 23 patients (96%). No patients presented with the resistant T790M mutation in the pretreatment sample, but at the time of disease progression the mutation was detected in plasma from 9 patients (39%). The quantitative data from the current study demonstrated that when a T790M mutation emerged in the blood it was accompanied by an increase in the original sensitizing EGFR mutation. When T790M was detected, it was found to be present in all subsequent blood samples from that patient. Most interestingly, the results of the current study demonstrated that monitoring the EGFR mutations in the blood allows for the detection of the T790M mutation up to 344 days before disease progression is clinically evident (range, 15‐344 days).CONCLUSIONSThe results of the current study demonstrated that serial monitoring of EGFR mutations in plasma DNA is feasible and may allow for the early detection of resistance mutations. These results warrant further studies to explore the clinical usefulness of such analysis. Cancer 2014;120:3896–3901. © 2014 The Authors. Cancer published by American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Efferent Pathways of the Mouse Lateral Habenula
Authors: Quina Lely A. , Tempest Lynne , Ng Lydia , Harris Julie A. , Ferguson Susan , Jhou Thomas C. , Turner Eric E. 
Published: August 2014

ABSTRACTThe lateral habenula (LHb) is part of the habenula complex of the dorsal thalamus. Recent studies of the LHb have focused on its projections to the ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg), which contain γ‐aminobutyric acid (GABA)ergic neurons that mediate reward prediction error via inhibition of dopaminergic activity. However, older studies in the rat have also identified LHb outputs to the lateral and posterior hypothalamus, median raphe, dorsal raphe, and dorsal tegmentum. Although these studies have shown that the medial and lateral divisions of the LHb have somewhat distinct projections, the topographic specificity of LHb efferents is not completely understood, and the relative extent of these projections to brainstem targets is unknown. Here we have used anterograde tracing with adeno‐associated virus–mediated expression of green fluorescent protein, combined with serial two‐photon tomography, to map the efferents of the LHb on a standard coordinate system for the entire mouse brain, and reconstruct the efferent pathways of the LHb in three dimensions. Using automated quantitation of fiber density, we show that in addition to the RMTg, the median raphe, caudal dorsal raphe, and pontine central gray are major recipients of LHb efferents. By using retrograde tract tracing with cholera toxin subunit B, we show that LHb neurons projecting to the hypothalamus, VTA, median raphe, caudal dorsal raphe, and pontine central gray reside in characteristic, but sometimes overlapping regions of the LHb. Together these results provide the anatomical basis for systematic studies of LHb function in neural circuits and behavior in mice. J. Comp. Neurol. 523:32–60, 2015. © 2014 Wiley Periodicals, Inc.
A capacitance‐ratio quantification design for linearity test in differential top‐plate sampling sar ADCS
Authors: Chao An‐Sheng , Lin Cheng‐Wu , Ting Hsin‐Wen , Chang Soon‐Jyh 
Published: August 2014

SummarySuccessive approximation register (SAR) analog‐to‐digital converters (ADCs) are widely used due to their low power consumption and area cost. However, testing SAR ADCs on an embedded chip is costly. This paper proposes a capacitance‐ratio quantification design for the linearity test of differential top‐plate sampling SAR ADCs. First, the pattern generator controls the switches connected to the bottom plate of capacitors to create a voltage difference proportional to a certain capacitance ratio on the top plates to be quantified. Then, the proposed mechanism quantifies the capacitance ratio via the auxiliary transistors connected to the input pair of the comparator in the SAR ADC. The capacitance ratios are recorded to construct the differential nonlinearity (DNL) and integral nonlinearity (INL) using the derived construction principles, which simplifies the implementation of the output response analyzer. Thus, the test time and area cost can be reduced with these two proposed mechanisms. For characterizing the DNL, the error between the results obtained using the proposed method and those obtained using conventional linear ramp histogram method is from −0.10 to 0.11 least significant bits (LSBs). For the INL, the estimation error is from −0.19 to 0.11 LSBs. Moreover, a test time reduction of about 76% is achieved at the expense of an 18.54% area overhead for the capacitance‐ratio quantification mechanism. Copyright © 2014 John Wiley & Sons, Ltd.