bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Standardized Diagnostic Interview for Hypoactive Sexual Desire Disorder in Women: Standard Operating Procedure (SOP Part 2)
Authors: Bitzer Johannes , Giraldi Annamaria , Pfaus Jim 
Published: September 2012

ABSTRACT

Introduction
Taking into account that Hypoactive Sexual Desire Disorder (HSDD) is a patient-reported symptom and that the disorder is in general the result of the interaction of biological and psychosocial factors (see part 1), it is necessary to provide healthcare professionals with an operating procedure that is patient centered and multidimensional.

Aim
Describing a patient-centered and multidimensional standard procedure to diagnose and manage HSDD on a primary care level.

Methods
Review of the literature. Semistructured interview and description of process.

Result
The interactive process with the patient follows several steps: initiation, narrative of the patient to understand the individual profile of the disorder, differentiating questions, descriptive diagnosis, exploration of conditioning biomedical, individual psychological, interpersonal, and sociocultural factors (including biomedical examinations), establishment of a biopsychosocial comprehensive explanatory diagnosis, which can be summarized in a nine-field matrix. This matrix will serve as orientation for therapeutic interventions adapted to the individual person. These interventions should always be based on basic counseling as a basis of treatment. Then adapted to the individual condition specific hormonal treatments (mainly estrogen and testosterone alone or combined) can be used after exclusion of contraindications. In patients with predominant psychosocial factors contributing to HSDD individual or couple psychotherapy is indicated. Psychopharmacological drugs are in development and partially investigated and will add to the therapeutic possibilities in the future.

Conclusion
This model can serve as an ideal basis for the approach to the female patient with HSDD. It can be adapted to the individual clinical setting.
Standard Operating Procedure for the Preservation of Erectile Function Outcomes After Radical Prostatectomy
Authors: Mulhall John P. , Bivalacqua Trinity J. , Becher Edgardo F. 
Published: September 2012

ABSTRACT

Introduction
Prostate cancer is common, and, thus, more men are being treated surgically. Long-term functional outcomes are of significant importance to the patient and their partners. Erectile function (EF) preservation (rehabilitation) has gained significant traction worldwide, despite the absence of definitive evidence supporting its use.

Aim
To review the effectiveness of specific pharmacological therapies and other erectogenic aids in the treatment of post-radical prostatectomy (RP) erectile dysfunction.

Methods
A systematic literature review of original peer-reviewed manuscripts and clinical trials reported in Medline.

Main Outcome Measure
This review focused on the evaluation of interventions that aimed to improve EF recovery following RP.

Results
Although well documented in animal models, studies supporting the rehabilitation with phosphodiesterase type 5 inhibitors in humans are scarce. Daily sildenafil has been used in trials (only one randomized placebo-controlled trial) with a significant improvement in erection recovery when compared to placebo or no rehabilitation but with a low return to baseline rates (27% vs. 4% placebo). Nightly vardenafil vs. on demand vs. placebo has been studied in the Recovery of Erections: INtervention with Vardenafil Early Nightly Therapy trial with no difference in erection recovery following RP. Intracavernosal injections, although widely used and attractive from a rehabilitation standpoint, does not yet have definitive supporting its role in rehabilitation. Vacuum erection devices use following RP has been reported, but there are no data to support its role as monotherapy. Intraurethral alprostadil was also studied vs. sildenafil in a multicenter, randomized, open-label trial, and no superiority was found.

Conclusions
At this time, we are unable to define what represents the optimal rehabilitation program in regard to strategies utilized, timing of intervention, or duration of treatment.
17‐year outcome of preterm infants with diverse neonatal morbidities: Part 2, impact on activities and participation
Authors: Sullivan Mary C. , Miller Robin J. , Msall Michael E. 
Published: September 2012

AbstractPurposeTo examine functioning and participation in a diverse U.S. sample of 180 infants at age 17 years.Design and MethodsThe World Health Organization International Classification of Functioning, Disability and Health model framed functioning and participation domains and contextual factors. Assessment included cognition, executive functioning, academic achievement, personal functioning, community participation, and social involvement.ResultsSocioeconomic status, not prematurity, impacted cognitive and academic outcomes. Across neonatal morbidities, male gender and social disadvantage are key determinants of cognitive, academic, and social functioning.Practice ImplicationsInterventions addressing academic and social–behavioral competencies in early school years may potentially optimize long‐term preterm outcomes.
SDSS J102623.61+254259.5: the second most distant blazar at z = 5.3
Authors: Sbarrato T. , Ghisellini G. , Nardini M. , Tagliaferri G. , Foschini L. , Ghirlanda G. , Tavecchio F. , Greiner J. , Rau A. , Gehrels N. 
Published: September 2012

Abstract
The radio-loud quasar SDSS J102623.61+254259.5, at a redshift z = 5.3, is one of the most distant radio-loud objects. Since its radio flux exceeds 100 mJy at a few GHz, it is also one of the most powerful radio-loud sources. We propose that this source is a blazar, i.e. we are seeing its jet at a small viewing angle. This claim is based on the spectral energy distribution of this source, and especially on its strong and hard X-ray spectrum, as seen by Swift, very typical of powerful blazars. Observations by the Gamma-Ray Burst Optical/Near-Infrared Detector (GROND) and by the Wide-field Infrared Survey Explorer (WISE) allow us to establish the thermal nature of the emission in the near-IR–optical band. Assuming that this is produced by a standard accretion disc, we derive that it emits a luminosity of Ld≃ 9 × 1046 erg s−1 and that the black hole has a mass between 2 and 5 billion solar masses. This poses interesting constraints on the mass function of heavy (&gt;109 M⊙) black holes at high redshifts.
Power prediction for one‐piece and three‐piece intraocular lens implantation after cataract surgery in patients with chronic angle‐closure glaucoma: a prospective, randomized clinical trial
Authors: Rhiu Soolienah , Lee Eun Suk , Kim Tae‐im , Lee Hye Sun , Kim Chan Yun 
Published: September 2012

Abstract.Purpose:  To assess the accuracy of intraocular lens (IOL) power prediction for cataract surgery in chronic angle‐closure glaucoma (CACG) patients with different IOLs’ implantation.Methods:  This prospective randomized clinical trial included 45 eyes with CACG and 48 eyes with normal controls undergoing cataract surgery. In the CACG group, 23 eyes (51%) had three‐piece IOL implantation and 22 eyes (49%) had one‐piece IOL implantation. In the normal control group, 25 eyes (52%) had three‐piece IOL implantation and 23 eyes (48%) had one‐piece IOL implantation. Using the SRK/T formula, the mean difference between the predicted and actual postoperative spherical equivalent [mean absolute error (MAE)] was obtained and converted to natural logarithm (ln) for statistical analysis. The power of the implanted IOL was calculated to predict postoperative SE using three formulas: SRK II, Holladay II and Hoffer Q by post hoc analysis in each group. The predictive accuracy of each formula was analysed by comparing the lnMAE.Results:  In the one‐piece IOL group, there was no difference in lnMAE between the CACG and normal control group (p = 0.314). In the three‐piece IOL group, the lnMAE of the CACG group was larger than that of the normal control group (p < 0.001). The lnMAEs calculated by the SRK/T formula were more accurate than the Holladay II (p = 0.045) and Hoffer Q (p = 0.042) formula in the CACG one‐piece IOL group.Conclusions:  Implantation of one‐piece IOLs provides similar power prediction accuracy comparable to normal cataract patients; this result may be explained by the IOL haptic configuration or design.
N‐chlorotaurine and its analogues N,N‐dichloro‐2,2‐dimethyltaurine and N‐monochloro‐2,2‐dimethyltaurine are safe and effective bactericidal agents in ex vivo corneal infection models
Authors: Teuchner Barbara , Eitzinger Christian , Lutz Matthias , Hager Thomas , Schmid Eduard , Bechrakis Nikolaos E. , Zuck Meghan , Jekle Andreas , Debabov Dmitri , Anderson Mark , Nagl Markus 
Published: September 2012

Abstract.Purpose:  N‐chlorotaurine (NCT) and its analogues N‐monochloro‐2,2‐dimethyltaurine (NVC‐612) and N‐dichloro‐2,2‐dimethyltaurine (NVC‐422) are new anti‐infectives for topical treatment for conjunctivitis. The aim of this study was to show that these compounds are safe in an EpiOcular model and effective in corneas infected ex vivo.Methods:  Corneal buttons were excised from porcine eyes. In 183 of the 229 corneas, erosion and artificial superficial stromal incision were induced. They were bathed in suspensions of Pseudomonas aeruginosa or Staphylococcus aureus for 24 hr at 37°C and incubated in solutions of the test substances at 37°C and pH 7.1. Subsequently, they were subjected to histology (n = 20) or homogenized followed by quantitative bacterial cultures (n = 209). Ocular irritation was tested using the EpiOcular™ tissue system (MatTek Corporation).Results:  Bacterial accumulations were detected histologically both on the corneal surface and also in the anterior third of the stroma of incised corneal buttons. All three test compounds at a concentration of 55 mm (equals 1% NCT) reduced the bacterial counts of P. aeruginosa and S. aureus by approximately 5 log10 after 60‐ and 120‐min incubation, respectively. Significant killing was observed as early as after 5‐min incubation. Also intrastromal bacteria were inactivated. In the EpiOcular™ tissue model, NCT, NVC‐422 and NVC‐612 had no or very low potential to irritate corneal tissue.Conclusion:  N‐chlorotaurine, NVC‐422 and NVC‐612 are non‐irritating in cornea and kill P. aeruginosa and S. aureus, even following penetration into the deeper corneal stromal layers.
Serum cardiac troponin I concentrations in dogs with leishmaniasis: correlation with age and clinicopathologic abnormalities
Authors: Silvestrini Paolo , Piviani Martina , Alberola Jordi , Rodríguez‐Cortés Alheli , Planellas Marta , Roura Xavier , O'Brien Peter James , Pastor Josep 
Published: September 2012

BackgroundThere is anecdotal evidence of myocardial injury in dogs with leishmaniasis due to generalized vasculitis and myocarditis.ObjectiveThe aims of this study were to evaluate serum concentration of cardiac troponin I (cTnI) as an indicator of myocardial injury in dogs with leishmaniasis and to assess the relationship between cTnI concentration and age, serum antibody titer, and a variety of blood analytes.MethodsIn this retrospective study, serum cTnI concentration was measured in dogs with leishmaniasis and in age‐matched healthy dogs. Diagnosis was based on clinical signs and moderate‐to‐high seropositivity forLeishmaniaas measured byELISA. Correlations between cTnI concentration andELISAseropositivity,PCV, concentrations of serum creatinine, total protein, albumin, and globulin, albumin:globulin ratio (A/G), and urine protein:creatinine ratio (UPC) were investigated. TheMann–Whitney test was used to compare analytes between dogs with normal and increased (> 0.06 μg/L) cTnI concentration and to compare cTnI concentrations between dogs with and without anemia, azotemia, and proteinuria.ResultsIn dogs with leishmaniasis (n = 40), median cTnI concentration was higher than in control dogs (n = 11) (P = .011). Sixteen dogs (40%) with leishmaniasis had increased cTnI concentration; cTnI was moderately to weakly correlated with decreased albumin concentration, decreased A/G, increasedUPC, decreasedPCV, positiveLeishmaniatiter, and increased age. Dogs with leishmaniasis had significantly higher total protein and globulin concentrations and lowerPCV, albumin concentration, and A/G than control dogs. Hematologic and biochemical analytes did not differ significantly between dogs with cTnI concentration within the reference interval and those with increased concentrations. Concentration of cTnI was higher in proteinuric dogs compared with nonproteinuric dogs (P = .017).ConclusionA proportion of dogs with leishmaniasis have increased serum cTnI concentration, indicative of some degree of cardiac injury. Additional studies are needed to investigate the relationship between leishmaniasis and possible myocardial injury.
The Impact of Objective and Subjective Measures of Air Quality and Noise on House Prices: A Multilevel Approach for Downtown Madrid
Authors: Chasco Coro , Gallo Julie Le 
Published: September 2012

AbstractAir quality and urban noise are major concerns in big cities. This article presents an evaluation of how they affect transaction prices in downtown Madrid. For this purpose, we incorporated both objective and subjective measures of air quality and noise and used multilevel models, since our sample was hierarchically organized into three levels: 5,080 houses (level 1) in 759 census tracts (level 2) and 43 neighborhoods (level 3). Variables are available for each level, individual characteristics for the first level, and various socioeconomic data for the other levels. We estimated multilevel hedonic models to assess the marginal willingness to pay for better air quality and reduced noise in downtown Madrid. We found that noise and air pollution are place‐based perception variables with a so‐called halo effect: residents in wealthier neighborhoods do not perceive their environment as being highly polluted because of their higher “sense of place.” In addition, we found a counterintuitive positive sign for the effect of objective measures of pollutants on housing prices but a significantly negative effect of the subjective measures. For these reasons, we conclude that housing prices are better explained by subjective evaluation factors than by objective measurements.
SmartTots: a public–private partnership between the United States Food and Drug Administration (FDA) and the International Anesthesia Research Society (IARS)
Authors: Ramsay James G. , Roizen Michael 
Published: September 2012

SummaryA history of the public–private partnership ‘SmartTots’ between the IARS and FDA is presented. In order to raise money for research to better understand the relationship between sedative and anesthetic agents and neurotoxicity in the developing brain, the FDA approached the IARS in 2008. A partnership was developed over the following 2 years, then a Scientific Advisory Board was created to develop a research agenda. The IARS contributed $200 000 in 2011 to provide initial funding; 33 proposals were submitted in response to a request for proposals in late 2011 and resulted in the awarding of two, $100 000 grants in 2012. An Executive Board was appointed under the leadership of Michael Roizen to spearhead additional fund‐raising efforts, and a director of development is working with Dr. Roizen and the Board to raise funds from individuals and organizations. Dr. Roizen has personally committed to a matching grant for anesthesiologists, up to $50 000 per year for 20 years ($1 million). Readers of the journal are encouraged to go to the website www.smarttots.org in order to better understand the issue, to contribute to the research fund themselves, and to encourage their own professional organizations to partner with SmartTots in fund‐raising.
MYB103 is required for FERULATE‐5‐HYDROXYLASE expression and syringyl lignin biosynthesis in Arabidopsis stems
Authors: Öhman David , Demedts Brecht , Kumar Manoj , Gerber Lorenz , Gorzsás András , Goeminne Geert , Hedenström Mattias , Ellis Brian , Boerjan Wout , Sundberg Björn 
Published: September 2012

SummaryThe transcription factor MYB103 was previously identified as a member of the transcriptional network regulating secondary wall biosynthesis in xylem tissues of Arabidopsis, and was proposed to act on cellulose biosynthesis. It is a direct transcriptional target of the transcription factor SECONDARY WALL ASSOCIATED NAC DOMAIN PROTEIN 1 (SND1), and 35S‐driven dominant repression or over‐expression of MYB103 modifies secondary wall thickness. We identified two myb103 T‐DNA insertion mutants and chemically characterized their lignocellulose by pyrolysis/GC/MS, 2D NMR, FT‐IR microspectroscopy and wet chemistry. The mutants developed normally but exhibited a 70–75% decrease in syringyl (S) lignin. The level of guaiacyl (G) lignin was co‐ordinately increased, so that total Klason lignin was not affected. The transcript abundance of FERULATE‐5‐HYDROXYLASE (F5H), the key gene in biosynthesis of S lignin, was strongly decreased in the myb103 mutants, and the metabolomes of the myb103 mutant and an F5H null mutant were very similar. Other than modification of the lignin S to G ratio, there were only very minor changes in the composition of secondary cell‐wall polymers in the inflorescence stem. In conclusion, we demonstrate that F5H expression and hence biosynthesis of S lignin are dependent on MYB103.
Redox regulation of glutenin subunit assembly in the plant endoplasmic reticulum
Authors: Lombardi Alessio , Marshall Richard S. , Castellazzi Chiara L. , Ceriotti Aldo 
Published: September 2012

SummaryThe glutenin fraction of wheat storage proteins consists of large polymers in which high‐ and low‐molecular‐weight subunits are connected by inter‐chain disulfide bonds. We found that assembly of a low‐molecular‐weight glutenin subunit in the endoplasmic reticulum is a rapid process that leads to accumulation of various oligomeric forms, and that this assembly is sensitive to perturbation of the cellular redox environment. In endoplasmic reticulum‐derived microsomes, low‐molecular‐weight glutenin subunits are subjected to hyper‐polymerization, indicating that cytosolic factors play an important role in limiting polymer size. Addition of physiological concentrations of reduced glutathione is sufficient to maintain the original polymerization pattern of the glutenin subunits upon cytosol dilution. Furthermore, we show that a low‐molecular‐weight glutenin subunit can be glutathionylated in endoplasmic reticulum‐derived microsomes, and that it can be directly reduced by glutathione in vitro. These results indicate that glutenin polymerization is sensitive to changes in the redox state of the cell, and suggest that the presence of a reducing cytosolic environment plays an important role in regulating disulfide bond formation in the endoplasmic reticulum of plant cells.
Dosimetric properties of radiophotoluminescent glass detector in low‐energy photon beams
Authors: Kadoya Noriyuki , Shimomura Kouhei , Kitou Satoshi , Shiota Yasuo , Fujita Yukio , Dobashi Suguru , Takeda Ken , Jingu Keiichi , Matsushita Haruo , Namito Yoshihito , Ban Syuichi , Koyama Syuji , Tabushi Katsuyoshi 
Published: September 2012

Purpose:A radiophotoluminescent glass rod dosimeter (RGD) has recently become commercially available. It is being increasingly used for dosimetry in radiotherapy to measure the absorbed dose including scattered low‐energy photons on the body surface of a patient and for postal dosimetry audit. In this article, the dosimetric properties of the RGD, including energy dependence of the dose response, reproducibly, variation in data obtained by the RGD for each energy, and angular dependence in low‐energy photons, are discussed.Methods:An RGD (GD‐301, Asahi Techno Glass Corporation, Shizuoka, Japan) was irradiated with monochromatic low‐energy photon beams generated by synchrotron radiation at Photon Factory, High Energy Accelerator Research Organization (KEK). The size of GD‐301 was 1.5 mm in diameter and 8.5 mm in length and the active dose readout volume being 1 mm diameter and 0.6 mm depth located 0.7 mm from the end of the detector. The energy dependence of the dose response and reproducibility and variation were investigated for RGDs irradiated with a plastic holder and those irradiated without the plastic holder. Response of the RGD was obtained by not only conventional single field irradiation but also bilateral irradiation. Angular dependence of the RGD was measured in the range of 0°–90° for 13, 17, 40, and 80 keV photon beams by conventional single field irradiation.Results:The dose responses had a peak at around 40 keV. For the energy range of less than 25 keV, all dose response curves steeply decreased in comparison with the ratio of mass energy absorption coefficient of the RGD to that of air. As for the reproducibility and variation in data obtained by the RGD, the coefficient of variance increased with decrease in photon energy. Furthermore, the variation for bilateral irradiation was less than that for single field irradiation. Regarding angular dependence of the RGD, for energies of 13 and 17 keV, the response decreased with increase in the irradiation angle, and the minimum values were 93.5% and 86%, respectively.Conclusions:Our results showed the dosimetric properties of the RGD, including the energy dependence of the dose response, reproducibly, variation, and angular dependence in low‐energy photons and suggest that the accuracy of the absorbed dose in low‐energy photons is affected by the readout method and the distribution of radiophotoluminescence centers in the RGD.
Automatic atlas‐based segmentation of the breast in MRI for 3D breast volume computation
Authors: Ortiz C. Gallego , Martel A. L. 
Published: September 2012

Purpose:Breast density is considered a significant risk factor and an important biomarker influencing the later risk of breast cancer. Prior breast segmentation is required when quantifying breast density with MRI in order to calculate the total breast volume and exclude nonbreast surrounding tissues. This paper describes an automatic 3D breast volume segmentation approach.Methods:The method is based on 3D local edge detection using phase congruency and Poisson surface reconstruction to extract the total breast volume. The boundary localization framework is integrated to a subsequent shape atlas‐based segmentation using a Laplacian framework.Results:The 3D segmentation achieves breast‐air and breast‐chest wall boundary localization errors with a median of 1.36 mm and 2.68 mm, respectively, and an average volume error of 153.8 cm3 when tested on 409 MRI datasets. Furthermore, the breast volume assessment technique will produce a 5.3% variability in the estimation of breast density in the tested population.Conclusions:The fully automated segmentation approach of the breast in MRI allows the computation of total breast volume, a step required for breast density assessment. The use of features invariant to image intensity and a shape atlas to reinforce shape consistency are attractive characteristics of the method. Error analysis demonstrates that 5.3% variability in the estimation of breast density incurred by the method is an acceptable trade‐off.