bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review on Biochemical Perspectives on Natural Products in Wound Healing: Exploring Phytochemicals in Tissue Repair and Scar Prevention
Authors: Raza Ali , Chohan Tahir Ali , Zaidi Syeda Huma H. , Hai Abdul , Alzahrani Abdullah R. , Abida  , Imran Mohd , Saleem Hammad 
Published: July 2024

AbstractWound healing is a critical process in tissue repair following injury, and traditional herbal therapies have long been utilized to facilitate this process. This review delves into the mechanistic understanding of the significant contribution of pharmacologically demonstrated natural products in wound healing. Natural products, often perceived as complex yet safely consumed compared to synthetic chemicals, play a crucial role in enhancing the wound‐healing process. Drawing upon a comprehensive search strategy utilizing databases such as PubMed, Scopus, Web of Science, and Google Scholar, this review synthesizes evidence on the role of natural products in wound healing. While the exact pharmacological mechanisms of secondary metabolites in wound healing remain to be fully elucidated, compounds from alkaloids, phenols, terpenes, and other sources are explored here to delineate their specific roles in wound repair. Each phytochemical group exerts distinct actions in tissue repair, with some displaying multifaceted roles in various pathways, potentially enhancing their therapeutic value, supported by reported safety profiles. Additionally, these compounds exhibit promise in the prevention of keloids and scars. Their potential alongside economic feasibility may propel them towards pharmaceutical product development. Several isolated compounds, including chlorogenic acid, thymol, and eugenol from natural sources, are undergoing investigation in clinical trials, with many reaching advanced stages. This review provides mechanistic insights into the significant role of pharmacologically demonstrated natural products in wound healing processes.
Natural Peroxides from Plants: Historical Discovery, Biosynthesis, and Biological Activities
Authors: Asmaey Mostafa A. , Hamed Abdelaaty , Shaaban Mohamed 
Published: July 2024

AbstractNaturally occurring peroxides received great interest and attention from scientific research groups worldwide due to their structural diversity, versatile biological activities, and pharmaceutical properties. In the present review, we describe the historical discovery of natural peroxides from plants systematically and update the researchers with recently explored ones justifying their structural caterogrization and biological/pharmaceutical properties intensively. Till the end of 2023, 192 peroxy natural products from plants were documented herein for the first time implying most categories of natural scaffolds (e. g. terpenes, polyketides, phenolics and alkaloids). Numerically, the reported plants’ peroxides have been classified into seventy‐four hydro‐peroxides, hundred seven endo‐peroxides and eleven acyl‐peroxides. Endo‐peroxides (cyclic alkyl peroxides) are an important group due to their high variety of structural frameworks, and we have further divided them into “four‐, five‐, six and seven”‐membered rings. Biosynthetically, a shedding light on the intricate mechanisms behind the formation of plant‐derived peroxides are addressed as well.
Morphological and Chemical Diversity within JapaneseLaurenciaComplex (Rhodomelaceae, Ceramiales, Rhodophyta)
Authors: Yamagishi Yukimasa , Kamada Takashi , Ishii Takahiro , Matsuura Hiroshi , Kikuchi Norio , Abe Tsuyoshi , Suzuki Minoru 
Published: July 2024

AbstractSeaweeds of the red algal genusLaurenciaare distributed worldwide in tropical, subtropical to temperate zones, growing in Japan from Hokkaido to Okinawa.Laurenciais highly difficult to classify morphologically because of a high degree of morphological variation within individual species. Nevertheless,Laurenciainvestigation is favored by organic chemists as it produces uniquely structured compounds. Halogenated secondary metabolites are considered to be used as chemical markers for chemical systematics (chemotaxonomy) of this troublesome genus. As a “weedy seaweed”,Laurenciais not effectively utilized, yet it produces a variety of metabolites and thus, holds good potential for containing compounds with specific activity, especially in aspects of secondary metabolites. In this review, we reported significant morphological features to distinguish species in this genus, and the morphological features, habitat, distribution, and chemical composition that help discriminate JapaneseLaurenciaspecies.
Superior oblique paresis after endoscopic brow lift: A case report
Authors: Shekarchian Farid , Motamed Shariati Mehrdad , Karimi Amir Abadi Mitra 
Published: July 2024

Key Clinical MessageAlthough a forehead lift is generally a safe surgery, it has well‐known complications. Iatrogenic SO paresis is one of the rare complications following forehead lifting procedures which almost resolves spontaneously.AbstractThis report aims to introduce a woman with superior oblique (SO) muscle paresis following the brow and forehead lift procedure. A 30‐year‐old woman with a history of brow and forehead lift surgery was referred to the ophthalmic emergency department complaining of vertical diplopia. A right eye hypertropia was obvious at the left gaze. A Park's three‐step test showed right eye superior oblique paresis. Other ophthalmic examinations including slit‐lamp examination, tonometry, and dilated fundoscopy were unremarkable for both eyes. After a 3‐month follow‐up period, she had no diplopia. No sign of SO paresis was apparent in her ocular motility examinations. Iatrogenic SO paresis is one of the rare complications following forehead lifting procedures which almost resolves spontaneously.
Breast milk‐transmitted acquired cytomegalovirus infection in an extremely low birth weight infant
Authors: Shinohara Tamao , Nemoto Atsushi , Fujihara Hiroyuki , Murakami Yasushi , Maebayashi Yuki , Saito Tomohiro , Katsumata Nobuyuki , Naitoh Atsushi 
Published: July 2024

Key Clinical MessageWe encountered an extremely low birth weight infant with breast milk‐transmitted cytomegalovirus (CMV) infection. To determine the transmission route, we conducted direct sequence analysis of two variable CMV genes, UL139, and UL146. When utilizing breast milk, the possibility of acquired CMV infection should be considered and tested for prompt diagnosis and treatment.
Recent Progress of Electrocatalysts Made by Sputtering Technology for Electrocatalytic Water Splitting
Authors: Gultom Noto Susanto , Ha Quoc‐Nam , Silitonga Mikha Zefanya , Kuo Dong‐Hau 
Published: July 2024

AbstractHydrogen is an emerging alternative green fuel for global decarbonization with a high energy density and zero‐emission. Developing electrocatalysts with strong adhesion, active, and highly efficient that can be operated at high current densities is vital to producing green hydrogen at a large scale via electrocatalytic water splitting (EWS). The sputtering technique is an innovative and prospective alternative to fabricate electrodes for EWS due to its scalability, purity, strong adhesion, chemical‐, solvent‐, and waste‐free catalyst preparation. This review article provides an overview of recent electrocatalyst advances for EWS made by the sputtering technique, emphasizing its distinct advantages over other methods, such as hydrothermal synthesis and drop‐casting. We also provide the recent difficulties associated with the scale‐up issue and outlook to overcome those difficulties, as well as the future direction of the electrocatalysts to meet industrial needs.
Immobilised Alcohol Dehydrogenase and Ene‐Reductase Work in Concert to Reduce Cyclohex‐2‐enone in Bulk Organic Solvent
Authors: Pintor Antía , Volkov Alexey , Lavandera Iván , Gotor‐Fernández Vicente 
Published: July 2024

AbstractEnone reduction by ene‐reductase (ERED) has not been reported yet in bulk organic media probably due to expected challenges with the cofactor recycling using a second enzyme and the exchange of the NAD(P)‐cofactor between the two enzymes. Herein, the combination of an ERED from Zymomonas mobilis (NCR‐ERED) and Thermoanaerobacter ethanolicus alcohol dehydrogenase (TeSADH) has been found as an efficient biocatalytic redox system for the reduction of cyclohex‐2‐enone into cyclohexanol in bulk organic solvents. Both enzymes were successfully immobilised on three EziG supports, finding Coral as the most promising carrier for both of them. The highest enzymatic activities were found in hydrophobic solvents such as toluene and isooctane. It was observed that the control of water content and post‐immobilisation treatments enabled retention of enzyme activity. Both enzymes were co‐immobilised on the same bead together with NADP+, leading to the production of a self‐sufficient catalytic system, although the external supplementation of the nicotinamide cofactor was necessary for an efficient enzyme reuse. In this case, no ERED activity loss was detected after two additional cycles, while the ADH experienced less than 20 % activity loss upon reuse.
A Rational Design Strategy for Metal Exchanged Zeolites in the Conversion of Methane to Methanol – A Pathway Towards Commercial Viability
Authors: Dorathy Daniel , Taylor Ethan W. , Göltl Florian 
Published: July 2024

AbstractMethane is a potent greenhouse gas, and reducing methane released to the atmosphere is crucial in limiting global warming. A promising strategy is to convert methane to higher valuable chemicals right after emission. One class of materials active for this chemistry are metal exchanged zeolites. In this concept paper, we describe how it is possible to rationalize the performance of metal exchanged zeolites for the selective conversion of methane to methanol. We explore how phase diagrams can be used to identify condition dependent active site structures, how synthesis can be used to stir site distribution, and how the performance of single metal sites can be calculated. Combining these three aspects then allows to understand and predict experimentally measured quantities such as methane conversion and spectroscopic signals. In the end, we outline the most promising strategies to bring this technology to industrial feasibility.
Suppressing Protodeboronation in Cu‐Mediated 19F/18F‐Fluorination of Arylboronic Acids: A Mechanistically Guided Approach Towards Optimized PET Probe Development
Authors: Sun Jingkai , Jaworski Carolin , Schirrmacher Ralf , Hall Dennis G. 
Published: July 2024

AbstractFluorinated arenes play a crucial role in drug discovery, specialty materials, and medical imaging. Although several variants for Cu‐mediated nucleophilic fluorination of arylboronic acids and derivatives have been developed, these protocols rarely address the occurrence and control of protodeboronation, which greatly complicates product separation and can compromise the effectiveness of a radiotracer for in vivo imaging. Consequently, simpler and more efficient procedures are needed to allow rapid 18F/19F‐fluorination of both arylboronic acids and esters while minimizing protodeboronation. Mechanistic controls revealed that in addition to a high temperature, strong donor ligands such as acetonitrile and pyridine accentuate a Cu‐mediated protodeboronation. This observation guided the optimization of a ligandless procedure, with t‐BuOH as solvent, to activate fluoride under milder conditions at lower temperatures minimizing protodeboronation. Additionally, a new copper salt, Cu(ONf)2 was employed to further improve the fluorination efficiency. A large range of functional groups are tolerated under the new procedure, which is complete within 30 minutes at a temperature of 60 °C, and affords fluorinated arenes and heteroarenes in 39 % to 84 % yield. With minimal modifications, the protocol can also be applied in 18F‐radiofluorination, affording radiochemical conversions (RCCs) between 17 and 54 % with minimal protodeboronation compared to previously established protocols.
Airborne pollen exposure and risk of hospital admission for allergic rhinitis in Beijing: A time‐stratified case‐crossover study
Authors: Ouyang Yuhui , Yang Jun , Zhang Jingxuan , Yan Yun , Sun Shengzhi , Wang Jiajia , Li Xiaobo , Chen Rui , Zhang Luo 
Published: July 2024

AbstractBackgroundAirborne pollen is a crucial risk factor in allergic rhinitis (AR). The severity of AR symptoms can vary based on pollen type and concentration. This study aimed to estimate the association between exposure to different pollen types and AR risk.MethodsWe obtained data from patients admitted to the Beijing Tongren Hospital for AR, and data on pollen concentration, meteorological factors, and fine particulate matter (PM2.5) from 13 districts in Beijing from 2016 to 2019. We used a time‐stratified case‐crossover study design and calculated odds ratios (ORs) related to the risk of AR associated with a 10 grain/1000 mm2 increase in total pollen concentrations for specific pollen types. A stratified analysis was conducted to assess whether the associations were varied by age and sex.ResultsThe OR of AR associated with a 10 grain/1000 mm2 increase in the 7‐day average pollen concentration was 1.014 (95% CI: 1.014, 1.015), 1.076 (95% CI: 1.070, 1.082), 1.024 (95% CI: 1.023, 1.025), 1.042 (95% CI: 1.039, 1.045), 1.142 (95% CI: 1.137, 1.147), 1.092 (95% CI: 1.088, 1.097), 1.046 (95% CI: 1.035, 1.058), and 1.026 (95% CI: 1.024, 1.028) for total pollen, Ulmus, Cupressaceae, Populus, Fraxinus, Pinus, Betula, and Artemisia, respectively. Both tree pollen (Ulmus, Cupressaceae, Populus, Fraxinus, Betula, and Pinus) and weed pollen (Artemisia, Chenopodium, and Humulus) were correlated with an increased risk of AR. These associations remained consistent across distinct subgroups defined by both age and sex.ConclusionExposure to pollen from trees and weeds might be associated with an increased risk of AR. This research provides valuable scientific support for both clinical practitioners and patients with AR regarding the hazards of pollen exposure.
Impact of three‐dimensional–printing technology guidance on surgical outcomes for retroperitoneal sarcoma: A propensity score‐matched study
Authors: Lin Jiaxin , Li Yingru , Feng Xiaochuang , Zhang Yu , Wang Jiahao , Liao Weilin , Li Hongming , Yi Xiaojiang , Gan Wenchang , Yuan Zhilong , Liu Fuheng , Shi Lishuo , Zeng Bing , Diao Dechang 
Published: July 2024

AbstractBackgroundThe surgical treatment of retroperitoneal sarcoma (RPS) is highly challenging because of its complex anatomy. In this study, the authors compared the surgical outcomes of patients with RPS who underwent surgical resection guided by three‐dimensional (3D) printing technology versus traditional imaging.MethodsThis retrospective study included 251 patients who underwent RPS resection guided by 3D‐printing technology or traditional imaging from January 2019 to December 2022. The main outcome measures were operative time, intraoperative blood loss, postoperative complications, and hospital stay.ResultsIn total, 251 patients were enrolled in the study: 46 received 3D‐printed navigation, and 205 underwent traditional surgical methods. Propensity score matching yielded 44 patients in the 3D group and 82 patients in the control group. The patients' demographics and tumor characteristics were comparable in the matched cohorts. The 3D group had significantly shorter operative time (median, 186.5 minutes [interquartile range (IQR), 130.0–251.3 minutes] vs. 210.0 minutes [IQR, 150.8–277.3 minutes]; p = .04), less intraoperative blood loss (median, 300.0 mL [IQR, 100.0–575.0 mL] vs. 375.0 mL [IQR, 200.0–925.0 mL]; p = .02), shorter postoperative hospital stays (median, 11.0 days [IQR, 9.0–13.0 days] vs. 14.0 days [IQR, 10.8–18.3 days]; p = .02), and lower incidence rate of overall postoperative complications than the control group (18.1% vs. 36.6%; p = .03). There were no differences with regard to the intraoperative blood transfusion rate, the R0/R1 resection rate, 30‐day mortality, or overall survival.ConclusionsPatients in the 3D group had favorable surgical outcomes compared with those in the control group. These results suggest that 3D‐printing technology might overcome challenges in RPS surgical treatment.Plain Language Summary

The surgical treatment of retroperitoneal sarcoma (RPS) is highly challenging because of its complex anatomy.
The purpose of this study was to investigate whether three‐dimensional (3D) printing technology offers advantages over traditional two‐dimensional imaging (such as computed tomography and magnetic resonance imaging) for guiding the surgical treatment of RPS.
In a group of patients who had RPS, surgery guided by 3D‐printing technology was associated with better surgical outcomes, including shorter operative time, decreased blood loss, shorter hospital stays, and fewer postoperative complications.
These findings suggested that 3D‐printing technology could help surgeons overcome challenges in the surgical treatment of RPS.
3D‐printing technology has important prospects in the surgical treatment of RPS.
Dark channel enhancement research on human ear images based on smartphone photography
Authors: Lu Dongxin , Zheng Danni , Kou Lei , Li Qingfeng , Ke Wende 
Published: July 2024

SummaryThe experienced doctors can alleviate symptoms such as headaches, insomnia, anxiety, and depression by observing the patient's ears and massaging specific areas. In order to achieve remote ear condition diagnosis and guide patients to massage their ears independently through the network, patients can use their mobile phones to take and send photos of ears to doctors. However, due to significant differences in the clarity of photos taken by different mobile phones, as well as susceptibility to haze, lighting, jitter, and low pixels, the quality of photos is poor, which affects the accuracy of remote diagnosis by doctors. This study adopted an image preprocessing method based on He Kaiming's dark channel prior dehazing method to enhance the original ear images captured by mobile phones. The dehazing algorithm was used to remove the haze effect of the ear images, improving image quality and contrast, making the wrinkles, protrusions, pigmentation and other areas of the ear more obvious. The experiment has showed the comparison by adjusting weight from 15% to 95% between two methods—dark channel prior method and the dark channel prior method after preprocessing, which has proven the effectiveness of dehazing method in human ear images taken by mobile phones. The image quality after preprocessing and dehazing is widely recognized and accepted by doctors at hospitals in Hangzhou, China.
Rotational Spectroscopy of the Acetone‐Water Complex: Large Amplitude Motions
Authors: Gao Jiao , Carlson Colton D. , Thomas Javix , Xu Yunjie , Jäger Wolfgang 
Published: July 2024

AbstractAcetone (CH3COCH3), the simplest ketone, has recently attracted considerable attention for its important role in atmospheric chemistry and in the formation of ices in extraterrestrial sources that contain complex organic molecules. In this study, we employed a combination of experimental rotational spectroscopy and quantum chemistry calculations to investigate the structure and dynamics of the acetone‐water complex. Our aim was to understand how non‐covalent interactions with water affect the methyl internal rotation dynamics of acetone, and how water‐centered large amplitude motions alter the observed physical properties compared to those predicted at the equilibrium position. Detailed rotation‐tunneling analyses of acetone‐H2O and ‐D2O reveal that the interactions with water disrupt the equivalence of the two methyl rotors, resulting in a noticeably lower methyl rotor barrier for the top with the close‐by water compared to that of free acetone. The barrier for the methyl group further from water is also lower, although to a lesser degree. To gain further insights, extensive theoretical modelling was conducted, focusing on the associated large amplitude motions. Furthermore, quantum theory of atoms in molecules and non‐covalent interactions analyses were utilized to visualize the underlying causes of the observed trends.
BOPHY Derivatives as Phototherapeutic Agents for the Photodynamic Inactivation of Microorganisms
Authors: Chávez Hernández Claudia , Palacios Yohana B. , Gonzalez Lopez Edwin J. , Lopez Maribel , Durantini Edgardo N. , Durantini Andrés M. , Agazzi Maximiliano L. , Heredia Daniel A. 
Published: July 2024

AbstractThe improvement of photodynamic inactivation (PDI) significantly depends on the development of new families of photosensitizers (PSs). In this sense, three BOPHY derivatives (BP, BP‐Br and BP‐I) were synthetized, studied, and compared to assess their antimicrobial photodynamic properties. BP is an interesting fluorescent probe for cell imaging, while the halogenated analogs (BP‐Br and BP‐I) are excellent oxygen photosensitizing agents. BP compound presented a fluorescence quantum yield close unity and showed no reactive oxygen species (ROS) production. In contrast, BP‐I did not show emission properties but exhibited a high production of ROS through both photodynamic mechanisms, generating singlet oxygen (type II) and superoxide radical anion (type I) under aerobic light irradiation. BP‐Br presented an adequate balance between ROS production and emission properties. The photokilling action and the binding to bacterial cells of these macrocycles were evaluated in vitro against methicillin‐resistant Staphylococcus aureus (MRSA) and Escherichia coli bacteria. Our results demonstrated that the halogenated BOPHY derivatives were effective PSs in inactivating MRSA using shorter irradiation periods. In addition, the antimicrobial action sensitized by these BOPHYs was potentiated by adding KI. The combination of halogenated BOPHY and KI led to a complete elimination of both Gram‐positive and Gram‐negative bacteria. Hence, BP‐Br and BP‐I prove to be potent broad‐spectrum antimicrobial PSs. To the best of our knowledge, this is the first time that BOPHY derivatives have been applied to photokill pathogenic microorganisms.
A Comprehensive Review on Biomethane Production from Biogas Separation and its Techno‐Economic Assessments
Authors: Swinbourn Ross , Li Chaoen , Wang Feng 
Published: July 2024

AbstractBiogas offers significant benefits as a renewable energy source, contributing to decarbonization, waste management, and economic development. This comprehensive review examines the historical, technological, economic, and global aspects of biomethane production, focusing on the key players such as China, the European Union, and North America, and associated opportunities and challenges as well as future prospects from an Australia perspective. The review begins with an introduction to biogas, detailing its composition, feedstock sources, historical development, and anaerobic digestion (AD) process. Subsequently, it delves into major biomethane production technologies, including physicochemical absorption, high‐pressure water scrubbing (HPWS), amine scrubbing (AS), pressure swing adsorption (PSA), membrane permeation/separation (MP), and other technologies including organic solvent scrubbing and cryogenic separation. The study also discusses general guidelines of techno‐economic assessments (TEAs) regarding biomethane production, outlining the methodologies, inventory analysis, environmental life cycle assessment (LCA), and estimated production costs. Challenges and opportunities of biogas utilization in Australia are explored, highlighting and referencing global projections, polarization in production approaches, circularity in waste management, and specific considerations for Australia. The review concludes discussing future perspectives for biomethane, emphasizing the importance of technological advancements, policy support, and investment in realizing its full potential for sustainable energy and waste management solutions.