bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and analysis of the protein-protein interaction network related to essential hypertension
Authors: Ran Jihua , Li Hui , Fu Jianfeng , Liu Ling , Xing Yanchao , Li Xiumei , Shen Hongming , Chen Yan , Jiang Xiaofang , Li Yan , Li Huiwu 
Published: April 2013

Abstract

Background
Essential hypertension (EH) is a complex disease as a consequence of interaction between environmental factors and genetic background, but the pathogenesis of EH remains elusive. The emerging tools of network medicine offer a platform to explore a complex disease at system level. In this study, we aimed to identify the key proteins and the biological regulatory pathways involving in EH and further to explore the molecular connectivities between these pathways by the topological analysis of the Protein-protein interaction (PPI) network.

Result
The extended network including one giant network consisted of 535 nodes connected via 2572 edges and two separated small networks. 27 proteins with high BC and 28 proteins with large degree have been identified. NOS3 with highest BC and Closeness centrality located in the centre of the network. The backbone network derived from high BC proteins presents a clear and visual overview which shows all important regulatory pathways for blood pressure (BP) and the crosstalk between them. Finally, the robustness of NOS3 as central protein and accuracy of backbone were validated by 287 test networks.

Conclusion
Our finding suggests that blood pressure variation is orchestrated by an integrated PPI network centered on NOS3.
Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms
Authors: Morgan Celia J. A. , Page Emma , Schaefer Carola , Chatten Katharine , Manocha Amod , Gulati Sumit , Curran H. Valerie , Brandner Brigitta , Leweke F. Markus 
Published: April 2013

SummaryAnandamide is a ligand of the endocannabinoid system. Animals show a depletion following repeated Δ9-tetrahydrocannabinol (THC) administration but the effect of cannabis use on central nervous system levels of endocannabinoids has not been previously examined in humans. Cerebrospinal fluid (CSF) levels of the endocannabinoids anandamide, 2-arachidonoylglycerol (2-AG) and related lipids were tested in 33 volunteers (20 cannabis users). Lower levels of CSF anandamide and higher levels of 2-AG in serum were observed in frequent compared with infrequent cannabis users. Levels of CSF anandamide were negatively correlated with persisting psychotic symptoms when drug-free. Higher levels of anandamide are associated with a lower risk of psychotic symptoms following cannabis use.
Role of the iridescent eye in stickleback female mate choice
Authors: Novales Flamarique Inigo , Bergstrom Carolyn , Cheng Christiana L. , Reimchen Thomas E. 
Published: April 2013

SummaryMany vertebrates exhibit prominent body colours that are used in courtship and territorial communication. Some fishes also have an eye whose iris becomes iridescent during the mating season, as in the threespine stickleback. Behavioural studies in this species have focused on the redness of the throat/jaw as the primary determinant of female mate choice. Unlike the iridescent eye, however, the red throat/jaw is not present in all stickleback populations, suggesting that the colour of the eye may be equally important for female mate choice. Here, we used data on photoreceptors and environmental light to assess body conspicuousness and the colour contrast of courtship signals for stickleback populations living in a range of waters, from clear (mesotrophic) to red light shifted (dystrophic). This analysis indicated that the redness of the throat/jaw is expressed to enhance the contrast of the eye. To test the importance of eye colour as a courtship signal, we carried out mate choice experiments in which females were presented with identical videos of a courting male but for the colour of the eye and/or the throat/jaw. Females did not choose based on differences in throat/jaw redness between videos, but preferred males with the highest contrast between the eye and the throat/jaw. This result points to the blue iridescent eye as the primary courtship signal in stickleback female mate choice.
Foundation doctors’ experience of their training: a questionnaire study
Authors: Dean Benjamin J F , Duggleby Philip Michael 
Published: April 2013

Summary Objectives We set out to evaluate the impact of Foundation Year (FY) training on the doctors who had been through this training system. Design Doctors in training were surveyed using a structured web-based questionnaire. Setting Postgraduate training in the UK has been the subject of much upheaval in recent years. Participants A total of 1065 doctors in training were surveyed in late 2011 and early 2012, of which 638 were current FY doctors. Main outcome measures The survey was both quantitative and qualitative, focusing on selection, working hours, training quality, training assessments and the regulation of training. Results A majority of current FY trainees worked extra weekly hours with the breakdown being: 5–10 hrs (54%), 10–15 hrs (17%), >15 hrs (9%) and no extra weekly hours (20%). All current FY trainees wanted to work for more than 40 h a week with the following breakdown of desired hours: per week 40–48 (22%), 48–60 (50%) and 60–70 h (19%). The average hours per week spent clerking emergency admissions by current FY trainees were as follows: zero hours (11%), 0–5 h (37%), 5–10 h (30%), 10–15 h (11%) and greater (11%). A large majority (90%) felt that it was possible for incompetent trainees to obtain satisfactory results from assessments and that the FY training program was poor at identifying failing trainees. There were high levels of dissatisfaction with the selection process. Conclusions FY training appears to be failing in several key areas with the lack of emergency exposure a particular area of concern. It is essential that any future reforms of training address these problem areas.
Dynamically recrystallized austenitic grain in a low carbon advanced ultra-high strength steel (A-UHSS) microalloyed with boron under hot deformation conditions
Authors: Mejía I. , García-Mora E. , Altamirano G. , Bedolla-Jacuinde A. , Cabrera J. M. 
Published: April 2013

ABSTRACTThis research work studies the dynamically recrystallized austenitic grain size (Drec) in a new family of low carbon NiCrCuV advanced ultra-high strength steel (A-UHSS) microalloyed with boron under hot deformation conditions. For this purpose, uniaxial hot-compression tests are carried out in a low carbon A-UHSS microalloyed with different amounts of boron (14, 33, 82, 126 and 214 ppm) over a wide range of temperatures (950, 1000, 1050 and 1100°C) and constant true strain rates (10−3, 10−2and 10−1s−1). Deformed samples are prepared and chemically etched with a saturated aqueous picric acid solution at 80°C in order to reveal theDrecand examined by light optical (LOM) and scanning electron microscopy (SEM). TheDrecis related to the Zener-Hollomon parameter (Z), and thereafter theDrecdivided by Burger's vector (b) is related to the steady state stress (σss) divided by the shear modulus (µ) (Derby model). Results shown that theDrecin the current steels is fine (≈ 23 μm) and almost equiaxed, and the recrystallized grain size-flow stress relationship observed after of plastic deformation is consistent with the general formulation proposed by Derby. It is corroborated that boron additions to the current A-UHSS do not have meaningful influence on theDrec.
On the characterization of eutectic grain growth during solidification
Authors: Morua M. , Ramirez-Argaez M. , Gonzalez-Rivera C. 
Published: April 2013

ABSTRACTThe purpose of this work is to compare the results obtained from three methodologies intended to estimate kinetic parameters describing quantitatively the grain growth during equiaxed eutectic solidification in order to identify the best procedure to characterize grain growth kinetics. A heat transfer / solidification kinetics model is implemented to simulate the cooling and solidification of eutectic Al-Si and eutectic cast iron in sand molds. Using simulated cooling curves and volume grain density data generated by the model, the three methods are applied to obtain their predicted grain growth coefficients. The predicted results are compared with the grain growth coefficients used in the model. The outcome of this work suggests that two of the three methods under study represent the best option to obtain the kinetic parameters of equiaxed growth during eutectic solidification.
Mullite Formation in Al2O3/SiO2/SiC Composites for Processing Porous Radiant Burners
Authors: Pottmaier Daphiny , Rosario Jefferson J. , Fredel Marcio C. , Oliveira Amir A.M. , Alarcon Orestes E. 
Published: April 2013

ABSTRACTUse of porous ceramic burners for natural gas combustion is an optimum alternative to enhance energy efficiency and decrease emission of pollutant gases per generated power. Materials requirements for the operation of such porous burners are mainly thermal shock and chemical resistance and those can be reached with cellular ceramics. Mullite was theoretically identified among the best materials for this application; however, its potential was not properly explored yet. Even though mullite can be synthesized from different compounds and processing routes, control of final material characteristics is complicated mainly due to the formation of amorphous phase. In this work, using a technological approach mullite burners were processed by the replication method starting from different mixtures of Al2O3/SiO2/SiC. Rheological study of the slurries has given additives content for the coating of the polyurethane sponges. After varying sintering temperatures up to 1600 °C and isotherm times for 12 h, microstructural aspects and product phases of the final composites were characterized in order to understand the influence of Al2O3/SiO2/SiC ratios in the formation of mullite phase and amorphous content.
Interactive presurgical simulation applying advanced 3D imaging and modeling techniques for skull base and deep tumors
Authors: Oishi Makoto , Fukuda Masafumi , Yajima Naoki , Yoshida Kenzo , Takahashi Machiko , Hiraishi Tetsuya , Takao Tetsuro , Saito Akihiko , Fujii Yukihiko 
Published: April 2013

Object
In this paper, the authors' goal was to report their novel presurgical simulation method applying interactive virtual simulation (IVS) using 3D computer graphics (CG) data and microscopic observation of color-printed plaster models based on these CG data in surgery for skull base and deep tumors.

Methods
For 25 operations in 23 patients with skull base or deep intracranial tumors (meningiomas, schwannomas, epidermoid tumors, chordomas, and others), the authors carried out presurgical simulation based on 3D CG data created by image analysis for radiological data. Interactive virtual simulation was performed by modifying the 3D CG data to imitate various surgical procedures, such as bone drilling, brain retraction, and tumor removal, with manipulation of a haptic device. The authors also produced color-printed plaster models of modified 3D CG data by a selective laser sintering method and observed them under the operative microscope.

Results
In all patients, IVS provided detailed and realistic surgical perspectives of sufficient quality, thereby allowing surgeons to determine an appropriate and feasible surgical approach. Surgeons agreed that in 44% of the 25 operations IVS showed high utility (as indicated by a rating of “prominent”) in comprehending 3D microsurgical anatomies for which reconstruction using only 2D images was complicated. Microscopic observation of color-printed plaster models in 12 patients provided further utility in confirming realistic surgical anatomies.

Conclusions
The authors' presurgical simulation method applying advanced 3D imaging and modeling techniques provided a realistic environment for practicing microsurgical procedures virtually and enabled the authors to ascertain complex microsurgical anatomy, to determine the optimal surgical strategies, and also to efficiently educate neurosurgical trainees, especially during surgery for skull base and deep tumors.
Valeur des informations comptables volontaires : illustration par le cas des publications sectorielles pour la période 1995-1996
Authors: Pourtier Frédéric 
Published: April 2013

L’objet de ce travail est d’étudier la valeur des informations comptables volontaires. L’hypothèse principale est que ces informations affectent le risque systématique de la firme. Les résultats infirment cette hypothèse : les informations volontaires ne semblent pas avoir de contenu informatif. Nous discutons alors du rôle d’un renforcement de la réglementation pour augmenter l’apport informatif de telles publications.
Contribution à l'analyse de la qualité du processus d'audit : le rôle de la relation entre le directeur financier et le commissaire aux comptes
Authors: Richard Chrystelle , Reix Robert 
Published: April 2013

Cette recherche propose de comprendre le rôle de la relation entre le directeur financier et le commissaire aux comptes dans le processus de l’audit et son influence sur la qualité de l’audit. Une démarche interprétative et qualitative est adoptée. Fondée sur des entretiens, cette étude qualitative est l’objet d’un processus interprétatif s’appuyant sur deux approches théoriques considérées comme complémentaires : les théories économiques contractuelles et la sociologie économique. Ce processus a permis ainsi de faire émerger deux notions constituant les bases de l’interprétation : le dualisme de la relation et la confiance hybride. Cette conception interprétative amène à une redéfinition de la relation entre le directeur financier et le commissaire aux comptes comme une relation de pairs. Les conditions d’émergence d’une relation de parité sont analysées comme le partage de normes professionnelles et culturelles, le degré de fréquence de la relation et la multiplicité de la relation. Une relation de pairs est alors caractérisée par une confiance hybride, une production conjointe de la connaissance et une égalité des rôles. Cette conception de la parité d’une relation conduit à une relecture des fondements de la qualité de l’audit, à savoir l’indépendance et la compétence de l’auditeur. La qualité d’un audit apparaît comme un équilibre entre ses deux déterminants, la compétence et l’indépendance.
Recherche « critique » en contrôle de gestion : exercer son discernement
Authors: Bessire Dominique 
Published: April 2013

Les dernières décennies de recherche en contrôle de gestion ont vu l’émergence d’une multitude de perspectives qui affichent leur opposition au structuro-fonctionnalisme ou au positivisme et, pour cette raison, sont fréquemment regroupées sous l’intitulé « courant critique ». Une série de cartes homologues fournit au chercheur les outils de discernement épistémologique susceptibles de lui permettre d’opérer ses choix en connaissance de cause. La carte qui synthétise les résultats de l’analyse montre que certaines perspectives de recherche « critique », tout en le décriant, ne font que renforcer le paradigme naturaliste, combinaison de matérialisme et de structuralisme. Elle révèle aussi la rareté de la référence au paradigme diamétralement opposé, le paradigme culturaliste, qui croise humanisme et idéalisme et qui, seul, accorde la primauté à l’être humain et à sa soif de réalisation.
Vie des affaires
Authors: Deshayes Christophe , Picard Robert 
Published: April 2013

De nouveaux usages du numérique prolifèrent pour aider au bien vivre : combattre ses addictions‚ bouger plus‚ manger mieux‚ surveiller son sommeil‚ etc. La France qui‚ aux yeux du monde‚ a les secrets de la qualité de vie‚ saura-t-elle en profiter ?
Improvement of Arterial Stiffness in the Transition From Acute Decompensated Heart Failure to Chronic Compensated Heart Failure
Authors: Kim Dong‐Bin , Baek Sang Hong , Jang Sung Won , Her Sung‐Ho , Shin Dong‐Il , Park Chan Seok , Park Hoon Joon , Kim Pum Joon , Jung Hae Ok , Seung Ki Bae 
Published: April 2013

AbstractBackgroundPulse wave velocity (PWV) is a well‐established marker for aortic stiffness and may be a prognostic factor in heart failure (HF). This study investigates whether PWV changes as patients transition from acute decompensated heart failure (ADHF) to chronic compensated heart failure (CCHF).HypothesisArterial stiffness is related with the development of HF.MethodsRegional PWV was prospectively measured using noninvasive applanation tonometry in consecutive ADHF patients (n = 55). PWV measurements of 45 patients were taken at admission and 3‐month follow‐up (F/U).ResultsCentral and upper‐extremity PWV, but not lower‐extremity PWVs, were found to have improved after 3 months compared with the admission PWV (central: 8.73 ± 1.17 vs 8.39 ± 0.99 m/s, P = 0.018; upper extremity: 8.59 ± 0.84 vs 8.33 ± 0.82 m/s, P = 0.028). Multivariate logistic regression analyses revealed that low‐density lipoprotein cholesterol was significantly associated with the change of PWV in HF (odds ratio: 1.037, 95% confidence interval: 1.003‐1.071, P = 0.030). In preserved left ventricular ejection fraction patients (n = 26) and ischemic patients (n = 31), central and upper‐extremity PWVs improved over the admission PWV at 3‐month F/U.ConclusionsThe present results indicate that central and upper‐extremity PWVs, but not lower‐extremity PWV, are increased in ADHF and improve as patients transition from ADHF to CCHF.
Tubulin‐β‐III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones
Authors: Roque Dana M. , Bellone Stefania , English Diana P. , Buza Natalia , Cocco Emiliano , Gasparrini Sara , Bortolomai Ileana , Ratner Elena , Silasi Dan‐Arin , Azodi Masoud , Rutherford Thomas J. , Schwartz Peter E. , Santin Alessandro D. 
Published: April 2013

BACKGROUNDUterine serous carcinoma (USC) is a subtype of endometrial cancer associated with chemoresistance and poor outcome. Overexpression of tubulin‐β‐III and p‐glycoprotein has been linked to paclitaxel resistance in many cancers but has been undercharacterized among USCs. Epothilones have demonstrated activity in certain paclitaxel‐resistant malignancies. In this study, relationships are clarified, in USCs relative to ovarian serous carcinomas (OSCs), between tubulin‐β‐III and p‐glycoprotein expression, clinical outcome, and in vitro chemoresponsiveness to epothilone B, ixabepilone, and paclitaxel.METHODSTubulin‐β‐III and p‐glycoprotein were quantified by real‐time polymerase chain reaction in 48 fresh‐frozen tissue samples and 13 cell lines. Copy number was correlated with immunohistochemistry and overall survival. Median inhibitory concentration (IC50) was determined using viability and metabolic assays. Impact of tubulin‐β‐III knockdown on IC50 was assessed with small interfering RNAs.RESULTSUSC overexpressed tubulin‐β‐III but not p‐glycoprotein relative to OSC in both fresh‐frozen tissues (552.9 ± 106.7 versus 202.0 ± 43.99, P = .01) and cell lines (1701.0 ± 376.4 versus 645.1 ± 157.9, P = .02). Tubulin‐β‐III immunohistochemistry reflected quantitative real‐time polymerase chain reaction copy number and overexpression stratified patients by overall survival (copy number ≤ 400: 615 days; copy number > 400: 165 days, P = .049); p‐glycoprotein did not predict clinical outcome. USCs remained exquisitely sensitive to patupilone in vitro despite tubulin‐β‐III overexpression (IC50,USC 0.245 ± 0.11 nM versus IC50,OSC 1.01 ± 0.13 nM, P = .006).CONCLUSIONSTubulin‐β‐III overexpression in USCs discriminates poor prognosis, serves as a marker for sensitivity to epothilones, and may contribute to paclitaxel resistance. Immunohistochemistry reliably identifies tumors with overexpression of tubulin‐β‐III, and a subset of individuals likely to respond to patupilone and ixabepilone. Epothilones warrant clinical investigation for treatment of USCs. Cancer 2013;119:2582–2592. © 2013 American Cancer Society.
Construction of a Multisoliton Blowup Solution to the Semilinear Wave Equation in One Space Dimension
Authors: Côte Raphaël , Zaag Hatem 
Published: April 2013

AbstractWe consider the semilinear wave equation with power nonlinearity in one space dimension. Given a blowup solution with a characteristic point, we refine the blowup behavior first derived by Merle and Zaag. We also refine the geometry of the blowup set near a characteristic point and show that, except for perhaps one exceptional situation, it is never symmetric with respect to the characteristic point. Then, we show that all blowup modalities predicted by those authors do occur. More precisely, given any integer k ≥ 2 and
$\zeta _0 \in {\cal R}$, we construct a blowup solution with a characteristic point a such that the asymptotic behavior of the solution near (a,T(a)) shows a decoupled sum of k solitons with alternate signs whose centers (in the hyperbolic geometry) have ζ0 as a center of mass for all times. © 2013 Wiley Periodicals, Inc.
Kinetic Evidence for a Non‐Langmuir‐Hinshelwood Surface Reaction: H/D Exchange over Pd Nanoparticles and Pd(111)
Authors: Savara Aditya , Ludwig Wiebke , Schauermann Swetlana 
Published: April 2013

AbstractThe mechanism of hydrogen recombination on a Pd(111) single crystal and well‐defined Pd nanoparticles is studied using pulsed multi‐molecular beam techniques and the H2/D2 isotope exchange reaction. The focus of this study is to obtain a microscopic understanding of the role of subsurface hydrogen in enhancing the associative desorption of molecular hydrogen. HD production from H2 and D2 over Pd is investigated using pulsed molecular beams, and the temperature dependence and reaction orders are obtained for the rate of HD production under various reaction conditions designed to modulate the amount of subsurface hydrogen present. The experimental data are compared to the results of kinetic modeling based on different mechanisms for hydrogen recombination. We found that under conditions where virtually no subsurface hydrogen species are present, the HD formation rate can be described exceptionally well by a classic Langmuir–Hinshelwood model. However, this model completely fails to reproduce the experimentally observed high HD formation rates and the reaction orders under reaction conditions where subsurface hydrogen is present. To analyze this phenomenon, we develop two kinetic models that account for the role of subsurface hydrogen. First, we investigate the possibility of a change in the reaction mechanism, where recombination of one subsurface and one surface hydrogen species (known as a breakthrough mechanism) becomes dominant when subsurface hydrogen is present. Second, we investigate the possibility of the modified Langmuir–Hinshelwood mechanism with subsurface hydrogen lowering the activation energy for recombination of two hydrogen species adsorbed on the surface. We show that the experimental reaction kinetics can be well described by both kinetic models based on non‐Langmuir–Hinshelwood‐type mechanisms.
Reduced products and sheaves of metric structures
Authors: Lopes Vinicius Cifú 
Published: April 2013

AbstractWe introduce reduced products in continuous logic, and provide ways to establish satisfaction in the reduced product based on the satisfaction in its fibers, and conversely, on the lines that Horn and Chang did for reduced products in classical logic. We also consider a definition of a sheaf of metric structures, endow its stalks with a metric prestructure, and determine what filters can be used so that a collection of reduced products of arbitrary structures forms a sheaf on a given index space.