bluuebunny/crossref_metadata_2025_split huggingface dataset:
CUTIS MARMORATA TELANGIECTATICA CONGENITA (CMTC) a.k.a. МӘРМӘР ТЕРІСІ БАР ТУА БІТКЕН ТЕЛАНГИЭКТАЗИЯ
Authors: Essengarayeva Z.B. , Beissebayeva U.T. , Sailauova K.S. , Keshileva R.K. , Zh A.S. 
Published: August 2024

By the healthy person, the thickness of the walls of blood vessels and capillaries is 20 micrometers, for this reason they are not visible simply to the gaze. Some diseases can increase this figure. Withering of the vessels, as well as the appearance on the skin of the educated cyanotic-red flowers, which characterize the appearance of vascular asterisks – telangiectasia. Scientific works and materials on the phenomenon of telangiectasia in particular, on congenital telangiectatic marble skin in infants, have been studied. There is presented a unique case of congenital telangiectasia with marble skin appearance of a male child. This case is regarded as innate teleangiectasia of marble skin appearance which is sporadic. Difficulty identifying causes of the disease can be attributed to Mother Nature (stealth, tolerance, and excessive obedience - destructive attitude to life of the child). Given the versatility of the defeat, the data neurosonography, the phenomenon of atrophy, the presence of' scarring in the place of the former elements indicate the possibility of occurrence of anomalies and other pathological conditions and during further development. Therefore, a dispensary control with, a wider clinical-laboratory and instrumental studies in the dynamics and advice of various experts in order to prevent possible complications.
Дені сау адамда қан тамырлары мен капиллярлардың қабырғаларының қалыңдығы 20 микрометрді құрайды, сондықтан олар қарапайым көрінбейді. Кейбір аурулар бұл көрсеткішті арттыруы мүмкін. Тамырлардың қурап қалуы, сондай-ақ теріде паук тамырларының пайда болуын сипаттайтын көкшіл - қызыл гүлдердің пайда болуы -телангиэктазия. Телеангиэктазия құбылысы, атап айтқанда нәрестелердегі туа біткен телеангиэктатикалық мәрмәр теріге қатысты ғылыми жұмыстар мен материалдар зерттелген. Ер балада мәрмәр тері бар туа біткен телеангиэктазияның бірегей жағдайы ұсынылған. Бұл жағдай сирек кездесетін мәрмәр терінің туа біткен телеангиэктазиясы ретінде қарастырылады. Аурудың себептерін анықтаудағы қиындықтарды табиғат-анаға жатқызуға болады (құпиялылық, төзімділік және шамадан тыс мойынсұнушылық - баланың өміріне деструктивті көзқарас). Зақымданудың әмбебаптығын ескере отырып, нейросонография деректері, атрофия құбылыстары және бұрынғы элементтердің орнында тыртықтардың болуы одан әрі дамуымен аномалиялар мен басқа патологиялық жағдайлардың мүмкіндігін көрсетеді. Сондықтан ықтимал асқынулардың алдын алу үшін диспансерлік бақылау, кеңірек клиникалық, зертханалық және аспаптық зерттеулер және әртүрлі мамандармен кеңесу қажет.
Pengaruh Laba Bersih dan Arus Kas Operasi Terhadap Harga Saham Pada PT. Alam Sutera Realty Tbk
Authors: Khairunnisyah Khairunnisyah  , Huda Nurul , Wulandari Wulandari  
Published: August 2024

This study aims to determine the simultaneous influence of net profit and operating cash flow on shares in PT. Alam Sutera Reality Tbk. This study is included in the category of population associative research in the study reveals that the sample is part of the number and characteristics possessed by the population. The sample in this study is the financial statements of PT. Alam Sutera Realty Tbk for 10 years, from 2014 to 2023. The sampling technique used in this study is purposive sampling. states that purposive sampling is a technique for determining samples with certain considerations. With the criteria of financial statements available for 10 consecutive years, namely 2014-2023. The 10-year sample data already represents the existing population data for research needs. Data collection techniques Documentation, Literature Study. The data analysis technique used the Classical Assumption Test, Normality Test, Multicollinearity Test, Heterokedasticity Test, Autocorrelation Test, Multiple Linear Regression Analysis, Determination Coefficient Test and Correlation Coefficient. Then processed using SPSS, the results of the study showed that Net Profit and Operating Cash Flow had a simultaneous effect on the share price of Pt Alam Sutera Realty Tbk.
Pengaruh Promosi Penjualan, Tampilan Toko Terhadap Pembelian Impulsif Pada Matahari Departement Store Solo Grand Mall
Authors: Olivia Stephanie Sarwono Putri  , R. Taufiq Nur Muftiyanto  , Esti Dwi Rahmawati  
Published: August 2024

Dalam menghadapi persaingan bisnis ritel yang semakin ketat, sangat penting untuk mengembangkan strategi yang dapat menarik lebih banyak perhatian pembeli terhadap produk. Penelitian ini bertujuan untuk menilai dampak promosi penjualan dan tampilan toko terhadap pembelian impulsif. Sampel yang digunakan terdiri dari 97 konsumen yang berbelanja di Matahari Departement Store Solo Grand Mall. Variabel yang diteliti mencakup promosi penjualan, tampilan toko, dan pembelian impulsif. Data primer dikumpulkan melalui kuesioner dan dianalisis dengan menggunakan metode Structural Equation Modeling-Partial Least Square (SEM PLS) serta SmartPLS 4.0. Hasil penelitian mengungkapkan bahwa promosi penjualan dan tampilan toko memiliki pengaruh positif dan signifikan terhadap pembelian impulsif.
THE STUDY ON TEACHERS' ABILITY IN USING ITEM ANALYSIS ON READING TEST AT ELEVENTH GRADE SMA MUHAMMADIYAH TEMBILAHAN
Authors: Aniswati  , Ardian Edi , Maizarah  
Published: August 2024

This study aims to describe the Items Analysis of the Reading Test Assessment Questions in Class IX SMA Muhammadiyah. This research is quantitative descriptive. Subject in This research is class IX students, totaling 16 students. Data collection techniques using the test method. The data were analyzed using the Excel program. The results of this study indicate that; There are 20 multiple choice questions the results are as follows: (1) In terms category of the level of difficulty, 11 items are found in the Hard category, 6 items in the medium category, 3 items in the easy category, (2) In terms category the category Discrimination power, there are 0 items that have very poor discriminatory power, 11 items have poor discriminatory power, 8 items have satisfactory discriminatory power, 1 item has good distinguishing power, and 0 items have good power excellent differentiator (3) In terms of the effectiveness of the distractor who chooses option Atotal of 17 items were accepted and 3 items were rejected, who chose option B as many as 19 items were accepted and 1 item was rejected, who chose option C as many as 19 items were accepted and 1 item was rejected, who chose option D as many as 18 items were accepted and 2 items were rejected, and those who chose option E were 17 items accepted and 3 items were rejected.
Pengaruh Bauran Pemasaran Terhadap Keputusan Pembelian Konsumen Pada Hypermart Nagoya Hill Batam
Authors: Hisyam Magneta 
Published: August 2024

Penelitian ini bertujuan untuk melihat seberapa besar pengaruh produk, harga,promosi, dan tempat terhadap keputusan pembelian konsumen pada Hypermart Nagoya Hill Batam. Penelitian ini dilakukan dengan pendekatan survey. Untuk membuktikan pengaruh Bauran pemasaran terhadap keputusan pembelian konsumen Hypermart Nagoya Hill Batam, maka penulis mengumpulkandata dengan cara penyebaran kuesioner yaitu sebanyak 100 responden sebagai sampel yang diambil dari seluruh konsumen Hypermart Nagoya Hill Batam. Data yang terkumpul melalui kuesioner diolah menggunakan aplikasi program SPSS.
Berdasarkan hasil penelitian menunjukan bahwa hasil Uji F (Simultan) menunjukan variabel produk, harga, promosi, dan tempat secara bersama-sama berpengaruh positif dan signifikan terhadap keputusan pembelian konsumen pada Hypermart Nagoya Hill Batam.
Hasil analisis regresi secara parsial (Uji T) menunjukkan bahwa variabel produk mempunyai pengaruh positif dan signifikan terhadap keputusan pembelian, variabel harga tidak mempunyai pengaruh positif dan signifikan terhadap keputusan pembelian; bahwa variabel promosi mempunyai pengaruh positif dan signifikan terhadap keputusan pembelian; dan variabel tempat mempunyai pengaruh positif dan signifikan terhadap keputusan pembelian konsumen berbelanja di Hypermart Nagoya Hill Batam
Computer English Teaching in Summer Learning Programs As Foreign Language
Authors: Shadmanov KB , Shukurova MA 
Published: August 2024

Language is the mode of identity and recognition. Summer learning programs are essential in helping children and young people interact and develop solid ethical bonds in different communities. Current issues related to the linguistic and philosophical nature of socio-ethical vocabulary in terms of diachronic are discussed in the article. Based on the analysis of a large amount of historical and philosophical material, the authors present their interpretation of the formation stages of the vocabulary of ethics as an integral part of the general philosophical vocabulary. However, each time and in each country, the interpretation of ethical concepts and norms, and therefore terms, was of a concrete historical and purely national character. In view of the objectives of this article, we consider it necessary to give a brief overview of the ethics of antiquity and the Middle Ages in order to understand and consider the specific role of ethics in science and practice of later historical eras. The authors hope that adopting pre-communicative activities as a part of the teaching method will be more effective in learning English as a foreign language.
Gender Equality Aiming Women Empowerment: Judges Made Law A Lighthouse
Authors: Anjaria Justice N.V. 
Published: August 2024

The Indian society has been traditionally patriarchal in its character, dominated by male-sponsored socio-cultural-political affairs and activities. The women who are otherwise integral part of family, community and society, have stood sidelined for their individual and participatory rights. The advancement of time has not ensured progress of class of women to avail them the equal place in the societal structures. The ideal of gender equality, which a democratic society empowered by Constitutional values would always cherish, has eluded in country’s collective walk.

The women individually and as a class wield high degree of strength, efficiency and intellectual power. It is a poignant observation by the Apex Court, ‘…self sacrifice and self denial are their nobility and fortitude and yet they have been subjected all inequities, indignities, inequality and discrimination’, in Madhu Kishwar v. State of Bihar[1].

[1] (1996) 5 SCC 125.
Favour the best in case of emergency cricothyroidotomy–a randomized cross-over trial on manikin focused training and simulation of common devices
Authors: Didion Nicole , Pohlmann Fabian , Pirlich Nina , Wittenmeier Eva , Jänig Christoph , Wollschläger Daniel , Griemert Eva-Verena 
Published: August 2024

Background
Performing an emergency cricothyroidotomy (EC) is extremely challenging, the devices used should be easy to handle and the selected technique reliable. However, there is still an ongoing debate concerning the most superior technique.

Methods
Three different techniques were compared using a standardized, simulated scenario regarding handling, performing, training and decision making: The scalpel-bougie technique (SBT), the surgical anatomical preparation technique (SAPT) and the Seldinger technique (ST). First, anaesthesia residents and trainees, paramedics and medical students (each group n = 50) performed a cricothyroidotomy randomly assigned with each of the three devices on a simulator manikin. The time needed for successful cricothyroidotomy was the primary endpoint. Secondary endpoints included first-attempt success rate, number of attempts and user-satisfaction. The second part of the study investigated the impact of prior hands-on training on both material selection for EC and on time to decision-making in a simulated “cannot intubate cannot ventilate” situation.

Results
The simulated scenario revealed that SBT and SAPT were significantly faster than percutaneous EC with ST (p < 0.0001). Success rate was 100% for the first attempt with SBT and SAPT. Significant differences were found with regard to user-satisfaction between individual techniques (p < 0.0001). In terms of user-friendliness, SBT was predominantly assessed as easy (87%). Prior training had a large impact regarding choice of devises (p < 0.05), and time to decision making (p = 0.05; 180 s vs. 233 s).

Conclusion
This study supports the use of a surgical technique for EC and also a regular training to create familiarity with the materials and the process itself.The trial was registered before study start on 11.11.2018 at ClinicalTrials.gov (NCT: 2018-13819) with Nicole Didion as the principal investigator.
Study of LY9 as a potential biomarker for prognosis and prediction of immunotherapy efficacy in lung adenocarcinoma
Authors: Deng Kun , Yuan Liqiang , Xu Zhanyu , Qin Fanglu , Zheng Zhiwen , Huang Liuliu , Jiang Wei , Qin Junqi , Sun Yu , Zheng Tiaozhan , Ou Xinhuai , Zheng Liping , Li Shikang 
Published: August 2024

Background
Lymphocyte antigen 9 (LY9) participates in the development of several tumors and diseases but has not been reported yet in lung adenocarcinoma (LUAD).

Methods
First, we analyzed the expression and prognostic value of LY9 in pan-cancer, including LUAD. Additionally, we conducted a correlation analysis of LY9 expression in LUAD with immune cell infiltration using the TIMER database and the CIBERSORT algorithm, and with immune checkpoints using the GEPIA database. Also, we constructed a potential ceRNA network for LY9. Furthermore, we explored LY9-related pathways by Gene Set Enrichment Analysis (GSEA). Finally, validation of differential expression at the mRNA level was obtained from the GEO database. We collected LUAD tissues for Quantitative Real-time PCR (qRT-PCR) to verify the expression of LY9, CD8, and CD4 and calculated the correlation between them. We also conducted immunohistochemistry (IHC) to verify the protein expression of LY9.

Results
Results showed that LY9 was highly expressed in various tumors, including LUAD. Besides, patients with high LY9 expression presented longer overall survival (OS) and more multiple lymphocyte infiltrations. The expression of LY9 in LUAD strongly and positively correlates with multiple immune cell infiltration and immune checkpoints. The functional enrichment analysis indicated that LY9 was involved in multiple immune-related pathways and non-small cell lung cancer. Moreover, a ceRNA regulatory network of LINC00943-hsa-miR-141-3p-LY9 might be involved. Finally, GSE68465 dataset confirmed differential expression of LY9 mRNA levels in LUAD and the qRT-PCR results verified LY9 had a strong and positive correlation with CD4 and CD8 T cells. Unfortunately, IHC did not detect the expression of LY9 protein level in tumor tissues and WB experiments validated the protein expression of LY9 in the OCI-AML-2 cell line.

Conclusions
Therefore, we hypothesized that LY9 could serve as a potential, novel prognostic biomarker for LUAD and could predict immunotherapy efficacy at the mRNA level.
DNA methylation and gene expression profiling reveal potential association of retinol metabolism related genes with hepatocellular carcinoma development
Authors: Zhao Yanteng , Wan Kangkang , Wang Jing , Wang Shuya , Chang Yanli , Du Zhuanyun , Zhang Lianglu , Dong Lanlan , Zhou Dihan , Zhang Wei , Wang Shaochi , Yang Qiankun 
Published: August 2024

Background
Aberrant DNA methylation patterns play a critical role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with these aberrantly methylated genes remain unclear. This study aimed to comprehensively investigate the methylation-driven gene expression alterations in HCC using a multi-omics dataset.

Methods
Whole genome bisulfite sequencing (WGBS) and RNA sequencing (RNA-seq) techniques were used to assess the methylation and gene expression profiles of HCC tissues (HCCs) and normal adjacent tissues (NATs). The candidate genes’ potential function was further investigated using single-cell RNA sequencing (scRNA seq) data.

Results
We observed widespread hypomethylation in HCCs compared to NATs. Methylation levels in distinct genomic regions exhibited significant differences between HCCs and NATs. We identified 247,632 differentially methylated regions (DMRs) and 4,926 differentially expressed genes (DEGs) between HCCs and NATs. Integrated analysis of DNA methylation and RNA-seq data identified 987 methylation-driven candidate genes, with 970 showing upregulation and 17 showing downregulation. Four genes involved in the retinol metabolic pathway, namely ADH1A, CYP2A6, CYP2C8, and CYP2C19, were identified as hyper-downregulated genes. Their expression levels could stratify HCCs into three subgroups with distinct survival outcomes, immune cell infiltration, and tumor microenvironments. Validation of these findings in an independent dataset yielded similar outcomes, confirming the high concordance and potential prognostic value of these genes. ScRNA seq data revealed the low expression of these genes in immune cells, emphasizing their role in promoting malignant cell proliferation and migration. In conclusion, this study provides insights into the molecular characteristics of HCC, revealing the involvement of retinol metabolism-related genes in the development and progression of HCC. These findings have implications for HCC diagnosis, prognosis prediction, and the development of therapeutic targets.
Efficacy and safety of etrolizumab in the treatment of inflammatory bowel disease: a meta-analysis
Authors: Dai Yong gang , Sun Dajuan , Liu Jiahui , Wei Xiunan , Chi Lili , Wang Hongya 
Published: August 2024

Background
To explore the efficacy and safety of etrolizumab in treating inflammatory bowel disease (IBD) through meta-analysis.

Method
A comprehensive exploration encompassed randomized controlled trials examining the efficacy of etrolizumab in treating IBD across PubMed, Embase, Cochrane library, and Web of Science, with a search deadline of 1 December 2023. Quality assessment leaned on the Cochrane manual’s risk-of-bias evaluation, while Stata 15 undertook the data analysis.

Result
Five randomized controlled studies involving 1682 individuals were finally included, Meta-analysis results suggested that compared with placebo, etrolizumab could improve clinical response (RR = 1.26, 95% CI [1.04–1.51]), clinical remission (RR = 1.26, 95% CI [1.04–1.51]) in IBD patients. Endoscopic alleviate (RR = 2.10, 95% CI [1.56–2.82]), endoscopic improvement (RR = 2.10, 95% CI [1.56–2.82]), endoscopic remission (RR = 2.10, 95% CI [1.56–2.82]), Endoscopic improvement (RR = 1.56, 95% CI [1.30–1.89]), histological remission (RR = 1.62, 95% CI [1.26–2.08]), and did not increase any adverse events (RR = 0.95, 95% CI [0.90–1.01]) and serious adverse events (RR = 0.94, 95% CI [0.68–1.31]).

Conclusion
According to our current study, etrolizumab is a promising drug in IBD.
A SWOT analysis for sustainable municipal solid waste management in Gurugram city, Haryana (India).
Authors: Chauhan Suman , Sandeep  
Published: August 2024

In developing countries, solid waste is typically disposed of inappropriately, which has a negative impact on the environment and healthcare. One of the most serious environmental issues is the management of municipal solid waste because of the huge increase in waste generation brought on by industrialization, economic development, urbanization, and the exponential growth of Gurugram City's population. Municipal Corporation Gurugram (MCG) handles solid waste collection, transportation, and disposal. The city generates over 1100 tons of solid waste per day. In consideration of this, the current study employed the strengths, weaknesses, opportunities, and threats framework called SWOT analysis to critically examine the city's current methods for the management of municipal solid waste to provide more effective policy solutions. For conducting the analysis, the questionnaires and other interviews were conducted to gather information from households and officials in the city, and the observation made during field visits were recorded. The analysis shows that the waste management issue is getting worse for a variety of causes, including a lack of regulatory enforcement, insufficient technical and financial resources, insufficient people’s participation, inadequate execution of policies, a lack of political priorities, and poor coordination between authorities.
Keywords: Solid Waste, Sustainable, SWOT, Urbanization
Growth and yield of Jatropha curcas l. as influenced by different regimes of apical bud removal
Authors: Adeniji, I.T.  , Togun, A.O.  , Adediran, J.A.  , Adeniji, A.M.  , Ogunwade, O.A.  , Omenna, E.C.  
Published: August 2024

An experiment was conducted on the influence of time of apical bud removal on the growth and yield of Jatropha curcas which has low performance due to poor production practices. Removal of apical dominance by decapitation has potential to improve yield of plants. However, the capacity at which decapitation can improve growth and yield of Jatropha curcashas not been adequately explored. The effects of decapitation was assessed on growth in pots in a research garden, University of Ibadan and growth and seed yield were examined on the field, at 6, 10, 14 and 18 weeks after sowing in the Institute of Agricultural Research and training, Ibadan. A control (without decapitation) was used as check. The experiments were arranged in pot and field studies using CRD and RCBD, respectively replicated four times. Number of leaves, number of branches, leaf area(cm2), dry weigh(g), days to flowering, days to fruiting, and days to fruit maturity and seed yield (g) were determined. Data were analysed using descriptive statistics and ANOVA at α0.05. The results from the pot experiment showed that plants decapitated at 6weeks had significantly (p>0.05) higher number of branches (6.3), Leaf area (1647.6cm2) and Dry weight (245.0g) than control (1.8; 898.7cm2 and 188.5g, respectively) and other treatments. On the field, days to flowering and days to fruit maturity showed that control plants (220.5 and 310.3)flowed and produced matured fruits earlier thanplants decapitated at 6weeks (223.8; 314.3).This was followed by decapitation at10 weeks(230.0; 321.0) and decapitation at 14weeks (238.0; 321.0).Plants decapitated at18weeks were the last to fruits and matured (240.8; 323.5). Highest Seed yield was at D6 (75.8) and least in control (29.0). The results showed that decapitation at six weeks after sowing increased growth and seed yield of Jatropha curcas.
Isolation of Bacillus thuringiensis from soil and their impact on mosquito larvae
Authors: John Shanthi Jenila J S , Sumathy Victor V. Judia Harriet 
Published: August 2024

Mosquitoes are vectors of various disease causing agents and are responsible for the transmission of pathogens causing more life threatening and debilitating human diseases than any other organism. Over one million people worldwide die from mosquito borne diseases which include Malaria, Chikungunya, Yellow fever and Dengue fever yearly within disease- endemic countries. Continuous use of chemical-based insecticides has resulted in the development of resistance in mosquito and cause detrimental effects on non-target organisms and thus causes human health problems. Bacillus thuringiensis is an important insect pathogen is highly toxic to mosquito larvae and related dipterans. Bacillus thuringiensis during the sporulation phase produces proteinaceous parasporal crystals called as delta-endotoxin. This crystal protein is active in alkaline condition of midgut of insects and gets solubilized and when activated by intrinsic protease results in an active toxin that selectively binds specific receptor in the cell membrane, leading to pore formation and consequent insect larvae death. Thus the present study reveals Bacillus thuringiensis to be highly active on mosquito pests and less likely to cause resistance and no effect to non-target animals and is thus considered beneficial to humans in the eradication of Mosquitoes.