bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a Home-Based Walking Intervention on Outcomes of Sleep Quality, Emotional Distress, and Fatigue in Patients Undergoing Treatment for Solid Tumors
Authors: Wenzel Jennifer A. , Griffith Kathleen A. , Shang JingJing , Thompson Carol B. , Hedlin Haley , Stewart Kerry J. , DeWeese Theodore , Mock Victoria 
Published: April 2013

Abstract

Learning Objectives
Describe the benefits and limited risks of a low-cost, home-based exercise program. Impart to patients information on an easily implemented, sustainable, at-home exercise intervention.

Purpose.
Exercise use among patients with cancer has been shown to have many benefits and few notable risks. The purpose of this study was to evaluate the impact of a home-based walking intervention during cancer treatment on sleep quality, emotional distress, and fatigue.

Methods.
A total of 138 patients with prostate (55.6%), breast (32.5%), and other solid tumors (11.9%) were randomized to a home-based walking intervention or usual care. Exercise dose was assessed using a five-item subscale of the Cooper Aerobics Center Longitudinal Study Physical Activity Questionnaire. Primary outcomes of sleep quality, distress, and fatigue were compared between the two study arms.

Results.
The exercise group (n = 68) reported more vigor (p = .03) than control group participants (n = 58). In dose response models, greater participation in aerobic exercise was associated with 11% less fatigue (p &lt; .001), 7.5% more vigor (p = .001), and 3% less emotional distress (p = .03), after controlling for intervention group assignment, age, and baseline exercise and fatigue levels.

Conclusion.
Patients who exercised during cancer treatment experienced less emotional distress than those who were less active. Increasing exercise was also associated with less fatigue and more vigor. Home-based walking is a simple, sustainable strategy that may be helpful in improving a number of symptoms encountered by patients undergoing active treatment for cancer.
Long-Term Risk Perceptions of Women With Ductal Carcinoma In Situ
Authors: Ruddy Kathryn J. , Meyer Meghan E. , Giobbie-Hurder Anita , Emmons Karen M. , Weeks Jane C. , Winer Eric P. , Partridge Ann H. 
Published: April 2013

Abstract

Learning Objectives
Identify predictors of excessive risk perception in women with a distant history of DCIS. Explain the importance of educating women with a history of DCIS about reasonable assessments of their risk for future breast cancer.

Introduction.
Previous research has demonstrated that many women with ductal carcinoma in situ (DCIS) overestimate their risk for future breast cancer at the time of diagnosis and soon thereafter. This study aims to evaluate risk perceptions after 5 years.

Patients and Methods.
In a longitudinal cohort study, we mailed long-term follow-up surveys to 315 women who had previously responded to a survey 18 months after they were diagnosed with DCIS, excluding those who had experienced recurrence and those not treated at our institution. We evaluated risk perceptions with items used previously in the cohort.

Results.
One hundred ninety-three women (61%) responded. The median time since diagnosis was 5.9 years. We excluded 12 because of recurrence. Of the 181 remaining, 32% perceived at least a moderate 5-year risk for developing DCIS again, 43% perceived at least a moderate lifetime risk for developing DCIS again, 27% perceived at least a moderate 5-year risk for invasive breast cancer, 38% perceived at least a moderate lifetime risk for invasive breast cancer, and 24% perceived at least a moderate risk for DCIS spreading to other body parts. In a multivariate model, worse financial status and higher perceived risk in the previous survey were the only predictors of at least a moderate perception of risk for DCIS spreading.

Conclusion.
Women with a history of DCIS continue to harbor inaccurate perceptions of their risk for future breast cancer events even 5 years after diagnosis.
Effects of bracket design on critical contact angle
Authors: Liu Xiaomo , Ding Peng , Lin Jiuxiang 
Published: April 2013

ABSTRACT

Objective:
To explore how the position of the bracket slots relative to the archwire influences the friction between them, and how bracket design affects the critical contact angle (θc).

Materials and Methods:
Two kinds of stainless steel archwires (0.016 and 0.019 × 0.025-inch) were tested against four kinds of brackets (Transmission Straight Archwire bracket, Domestic MBT bracket, Tip-Edge Plus bracket, and BioQuick self-ligation bracket) in the dry state. Resistance to sliding (RS) was measured as an increase in contact angle (θ). The value of θc was calculated by two linear regression lines.

Results:
Friction remained stable when θ &lt; θc, then increased linearly when θ &gt; θc. The θc values of the Tip-Edge Plus bracket and Transmission Straight Archwire bracket were significantly larger than those for the Domestic MBT bracket and BioQuick self-ligation bracket.

Conclusions:
The relationship between the archwire and bracket slot significantly affects the resistance to sliding. The “edge-off” structure of the Tip-Edge Plus bracket and Transmission Straight Archwire bracket could help to increase the θc value, and to expand the passive configuration range.
Composite vs Ceramic Computer-aided Design/Computer-assisted Manufacturing Crowns in Endodontically Treated Teeth: Analysis of Marginal Adaptation
Authors: Ramírez-Sebastià A , Bortolotto T , Roig M , Krejci I 
Published: April 2013

SUMMARY

Objectives
To compare the marginal adaptation between ceramic and composite CEREC crowns in endodontically treated teeth restored with endocrowns or with a short or a long post.

Methodology
Forty-eight intact maxillary incisors were used. After endodontic treatment, the crowns were sectioned 2 mm coronally to the cemento-enamel junction, which provided a ferrule of 2 mm. The prepared teeth were divided randomly into six groups (n=8). Group 1 was restored with a large fiberglass post, composite core, and ceramic full-coverage computer-aided design/computer-assisted manufacturing (CAD-CAM) crown. Group 2 was restored with a short fiberglass post, composite core, and ceramic full-coverage CAD-CAM crown. Group 3 was restored with a large fiberglass post, composite core, and composite full-coverage CAD-CAM crown (LPCpr). Group 4 was restored with a short fiberglass post, composite core, and composite full-coverage CAD-CAM crown (SPCpr). Groups 5 and 6 were restored with ceramic and composite CEREC machined endocrowns, respectively (EndoCer and EndoCpr). The restored teeth were loaded thermomechanically in a computer-controlled chewing machine. Impressions of each restoration were made in a polyvinylsiloxane material before and after loading. Gold-coated epoxy replicas were prepared for scanning electron microscopy examination at 200× magnification.

Results
Loading had a statistically significant effect (p&lt;0.05) on the percentage of “continuous margin” in all groups. The LPCpr, SPCpr, and EndoCpr groups showed the highest percentage of continuous margin initially and after loading. The effect of the different post lengths on marginal adaptation was not significant (p&gt;0.05).

Conclusion
CAD-CAM crowns fabricated from millable composite resin blocks (Paradigm MZ100) offer a superior option to all-ceramic crowns (IPS Empress CAD).
A Computational Study of the Factors Influencing Pressure in Arteriovenous Fistulae Venous Aneurysms
Authors: Georgakarakos Efstratios I. , Xenakis Antonios , Kapoulas Konstantinos C. , Tsangaris Sokrates , Georgiadis George S. , Lazarides Miltos K. 
Published: April 2013

Purpose To investigate the factors influencing the hydrostatic pressure exerted within the venous aneurysms (VA) of an arteriovenous fistula (AVF). Methods Ideal models of a side-to-end brachial-cephalic AVF were computationally constructed and typical values for the length and the local diameters were considered for both the artery and vein sections of the models. Three VA configurations were reconstructed (spherical, fusiform and curved) and hydrostatic pressure was assessed with respect to different degrees of the outflow vein stenosis, ranging from 25% to 95%, and VA maximum diameters, using validated, commercially available software. Results The pressure in the VA was steady (1200 Pa) for venous outflow stenoses up to 75%. For stenoses greater than 75% a exponential pressure rise was observed, reaching 1500 Pa for stenoses of 95%. Neither the VA configuration nor its maximum diameter affected the pressure values exerted within the VA or the point of the pressure upstroke. Conclusions our study supports the presence of a critical stenotic outflow vein diameter beyond which there is an exponential VA pressure increase, influenced neither by the shape nor the size of the VA. Whether the prompt, non-invasive detection of this finding can contribute or lead to the determination of a criterion for early intervention in VAs before clinical complications are developed, should be investigated by future studies.
La discipline francophone des Relations internationales au Québec et au Canada
Authors: Grondin1 David , D’Aoust Anne-Marie , Racine-Sibulka Paul 
Published: April 2013

Depuis les années 1990, les RI francophones semblent avoir connu un essor important au point de s’imposer comme l’un des sous-champs les plus populaires pour les étudiants de baccalauréat et des cycles supérieurs au Québec et au Canada francophone. Au-delà de ces développements institutionnels importants et à la lumière des conclusions posées par Cornut et coll. (dans ce numéro) sur les nouveaux politologues francophones, quel bilan peut-on dresser des « RI francophones » ? On a peu questionné l’effet de la pratique la plus évidente des RI, soit l’usage hégémonique de l’anglais, sur les RI dans le Canada et le Québec francophones et notamment sur les nouveaux doctorants qui y sont formés. Il nous apparaissait ainsi important de souligner que le bilan des RI francophones au Canada et au Québec nécessite que l’on questionne non seulement la singularité intellectuelle apportée par l’épithète « francophones » ajoutée à « RI », mais également la soi-disant nature proprement anglophone de la discipline des RI. Les conclusions de la sociologie de la discipline centrées sur le rôle politique de la langue dans la recherche et l’enseignement offertes dans ce texte espéraient rendre plus saillante la réalité des différentes structures de pouvoir en lien avec la production d’un savoir dans une langue plutôt qu’une autre. En soulevant certaines questions difficiles avec lesquelles les étudiants et les professeurs en RI sont aux prises et en proposant certaines mesures concrètes, nous n’espérons pas tant susciter la controverse, inévitable et nécessaire lorsque des questions d’ordre politique sont soulevées, que semer les germes d’un débat crucial à venir quant à l’avenir d’une production intellectuelle francophone en RI et la formation de doctorants francophones en RI au Québec et au Canada.
Bioelectronic Implantable Devices for Physiological Signal Recording and Closed‐Loop Neuromodulation
Authors: Oh Saehyuck , Jekal Janghwan , Liu Jia , Kim Jeehwan , Park Jang‐Ung , Lee Taeyoon , Jang Kyung‐In 
Published: July 2024

AbstractBioelectronic implantable devices are adept at facilitating continuous monitoring of health and enabling the early detection of diseases, offering insights into the physiological conditions of various bodily organs. Furthermore, these advanced systems have therapeutic capabilities in neuromodulation, demonstrating their efficacy in addressing diverse medical conditions through the precise delivery of stimuli directly to specific targets. This comprehensive review explores developments and applications of bioelectronic devices within the biomedical field. Special emphasis is placed on the evolution of closed‐loop systems, which stand out for their dynamic treatment adjustments based on real‐time physiological feedback. The integration of Artificial Intelligence (AI) and edge computing technologies is discussed, which significantly bolster the diagnostic and therapeutic functions of these devices. By addressing elemental analyses, current challenges, and future directions in implantable devices, the review aims to guide the pathway for advances in bioelectronic devices.
Synovial Lubrication Factors‐Recruiting Biomimetic Polyphenolized Hyaluronic Acid for Promoting Cartilage Repair
Authors: Yuan Hui , Xiao Pengcheng , Sarmento Bruno , Chen Gang , Cui Wenguo 
Published: July 2024

AbstractOsteoarthritis is a common degenerative disease characterized by continuous detachment of lubrication factors from damaged cartilage matrix. This study proposes a paradigm that combines natural polyanionic polysaccharides (hyaluronic acid, HA) with dopamine (DA) to design a synovial lubrication factors‐recruiting biomimetic polyphenolized lubrication system. The biomimetic lubricants can use DA's polarity and hydrophilic groups as specific binding sites of type II collagen's polarity and hydrophilic groups to stably bind cartilage surface, and further utilize molecular specific interaction to recruit detached, joint endogenous or chondrocytes expressed synovial lubrication factors, continuously forming supramolecular lubrication complex onto cartilage matrix to induce joint lubrication. Simultaneously, the biolubricants can also utilize catechol groups to eliminate anionic free radicals and resist reactive oxygen species invasion in the early stages of joint lubrication failure. The prepared biolubricants exhibit low coefficient of friction (µ < 0.08), which is attributed to fluid and hydration lubrication provided by HA and DA side chains through fluid dynamic effect and interfacial hydration adsorption. Cell and animal experiments also demonstrate polyphenolic biolubricants have good biocompatibility and promote cartilage regeneration. Therefore, the developed synovial lubricants‐recruiting biomimetic polyphenolized biolubricants have potential for treating osteoarthritis, and also provide a theoretical basis for other biological tissues with lubrication problems.
Reverse Hydrogen Spillover on Metal Oxides for Water‐Promoted Catalytic Oxidation Reactions
Authors: Fu Hao , Liu Hongjie , Wang Xiyang , Zhang Wenhua , Zhang Hui , Luo Yunhong , Deng Xianwang , King Graham , Chen Ning , Wang Liwei , Wu Yimin A. 
Published: July 2024

AbstractUnderstanding the water‐involved mechanism on metal oxide surface and the dynamic interaction of water with active sites is crucial in solving water poisoning in catalytic reactions. Herein, this work solves this problem by designing the water‐promoted function of metal oxides in the ethanol oxidation reaction. In situ multimodal spectroscopies unveil that the competitive adsorption of water‐dissociated *OH species with O2 at Sn active sites results in water poisoning and the sluggish proton transfer in CoO‐SnO2 imparts water‐resistant effect. Carbon material as electron donor and proton transport channel optimizes the Co active sites and expedites the reverse hydrogen spillover from CoO to SnO2. The water‐promoted function arises from spillover protons facilitating O2 activation on the SnO2 surface, leading to crucial *OOH intermediate formation for catalyzing C‐H and C‐C cleavage. Consequently, the tailored CoO‐C‐SnO2 showcases a remarkable 60‐fold enhancement in ethanol oxidation reaction compared to bare SnO2 under high‐humidity conditions.
Body‐Wide Inactivation of the Myc‐Like Mlx Transcription Factor Network Accelerates Aging and Increases the Lifetime Cancer Incidence
Authors: Wang Huabo , Stevens Taylor , Lu Jie , Roberts Alexander , Van't Land Clinton , Muzumdar Radhika , Gong Zhenwei , Vockley Jerry , Prochownik Edward V. 
Published: July 2024

AbstractThe “Mlx” and “Myc” transcription factor networks cross‐communicate and share many common gene targets. Myc's activity depends upon its heterodimerization with Max, whereas the Mlx Network requires that the Max‐like factor Mlx associate with the Myc‐like factors MondoA or ChREBP. The current work demonstrates that body‐wide Mlx inactivation, like that of Myc, accelerates numerous aging‐related phenotypes pertaining to body habitus and metabolism. The deregulation of numerous aging‐related Myc target gene sets is also accelerated. Among other functions, these gene sets often regulate ribosomal and mitochondrial structure and function, genomic stability, and aging. Whereas “MycKO” mice have an extended lifespan because of a lower cancer incidence, “MlxKO” mice have normal lifespans and a higher cancer incidence. Like Myc, the expression of Mlx, MondoA, and ChREBP and their control over their target genes deteriorate with age in both mice and humans. Collectively, these findings underscore the importance of lifelong and balanced cross‐talk between the two networks to maintain proper function and regulation of the many factors that can affect normal aging.
Serum and Urine Metabolic Fingerprints Characterize Renal Cell Carcinoma for Classification, Early Diagnosis, and Prognosis
Authors: Xu Xiaoyu , Fang Yuzheng , Wang Qirui , Zhai Shuanfeng , Liu Wanshan , Liu Wanwan , Wang Ruimin , Deng Qiuqiong , Zhang Juxiang , Gu Jingli , Huang Yida , Liang Dingyitai , Yang Shouzhi , Chen Yonghui , Zhang Jin , Xue Wei , Zheng Junhua , Wang Yuning , Qian Kun , Zhai Wei 
Published: July 2024

AbstractRenal cell carcinoma (RCC) is a substantial pathology of the urinary system with a growing prevalence rate. However, current clinical methods have limitations for managing RCC due to the heterogeneity manifestations of the disease. Metabolic analyses are regarded as a preferred noninvasive approach in clinics, which can substantially benefit the characterization of RCC. This study constructs a nanoparticle‐enhanced laser desorption ionization mass spectrometry (NELDI MS) to analyze metabolic fingerprints of renal tumors (n = 456) and healthy controls (n = 200). The classification models yielded the areas under curves (AUC) of 0.938 (95% confidence interval (CI), 0.884–0.967) for distinguishing renal tumors from healthy controls, 0.850 for differentiating malignant from benign tumors (95% CI, 0.821–0.915), and 0.925–0.932 for classifying subtypes of RCC (95% CI, 0.821–0.915). For the early stage of RCC subtypes, the averaged diagnostic sensitivity of 90.5% and specificity of 91.3% in the test set is achieved. Metabolic biomarkers are identified as the potential indicator for subtype diagnosis (p < 0.05). To validate the prognostic performance, a predictive model for RCC participants and achieve the prediction of disease (p = 0.003) is constructed. The study provides a promising prospect for applying metabolic analytical tools for RCC characterization.
Interfacial Denaturation at the Droplet Simplifies the Formation of Drug‐Loaded Protein Nanocapsules to Enhance Immune Response of Cells
Authors: Chali Sharafudheen Pottanam , Kang Jinhong , Fichter Michael , Speth Kai Robert , Mailänder Volker , Landfester Katharina 
Published: July 2024

AbstractNanocapsules enable multicomponent encapsulation of therapeutic cargoes with high encapsulation content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking is used to synthesize nanocapsules, which can impede the regulatory approval process. Therefore, a new class of protein nanocapsules is developed by eliminating the need for chemical crosslinking by utilizing protein denaturation through a process that is referred to as “baking at the droplet interface”. Such protein nanocapsules with antigens incorporated in the shell and a combination of encapsulated drugs showed an enhancement in the immune response of cells.
Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells
Authors: Barnieh Francis M. , Morais Goreti Ribeiro , Loadman Paul M. , Falconer Robert A. , El‐Khamisy Sherif F. 
Published: July 2024

AbstractTargeted therapy remains the future of anti‐cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical potential, and are currently being evaluated in the clinic. However, despite the considerable optimism for clinical success of these inhibitors, reports of associated normal tissues toxicities remain a concern and can compromise their utility. Here, ICT10336 is reported, a newly developed hypoxia‐responsive prodrug of ATR inhibitor, AZD6738, which is hypoxia‐activated and specifically releases AZD6738 only in hypoxic conditions, in vitro. This hypoxia‐selective release of AZD6738 inhibited ATR activation (T1989 and S428 phosphorylation) and subsequently abrogated HIF1a‐mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. Importantly, in normal tissues, ICT10336 is demonstrated to be metabolically stable and less toxic to normal cells than its active parent agent, AZD6738. In addition, ICT10336 exhibited a superior and efficient multicellular penetration ability in 3D tumor models, and selectively eradicated cells at the hypoxic core compared to AZD6738. In summary, the preclinical data demonstrate a new strategy of tumor‐targeted delivery of ATR inhibitors with significant potential of enhancing the therapeutic index.
3D Bulk Metamaterials with Engineered Optical Dispersion at Terahertz Frequencies Utilizing Amorphous Multilayered Split‐Ring Resonators
Authors: Huang Ying , Kida Takanori , Wakiuchi Shun , Okatani Taiyu , Inomata Naoki , Kanamori Yoshiaki 
Published: July 2024

AbstractA 3D bulk metamaterial (MM) containing amorphous multilayered split‐ring resonators is proposed, fabricated, and evaluated. Experimentally, the effective refractive index is engineered via the 3D bulk MM, with a contrast of 0.118 across the frequency span from 0.315 to 0.366 THz and the index changing at a slope of 2.314 per THz within this frequency range. Additionally, the 3D bulk MM exhibits optical isotropy with respect to polarization. Moreover, the peak transmission and optical dispersion are tailored by adjusting the density of the split‐ring resonators. Compared to reported conventional approaches for constructing bulk MMs, this approach offers advantages in terms of the potential for large‐scale manufacturing, the ability to adopt any shape, optical isotropy, and rapid optical dispersion. These features hold promise for dispersive optical devices operating at THz frequencies, such as high‐dispersive prisms for high‐resolution spectroscopy.
Functionalized Thienopyrazines on NiOx Film as Self‐Assembled Monolayer for Efficient Tin‐Perovskite Solar Cells Using a Two‐Step Method
Authors: Kuan Chun‐Hsiao , Afraj Shakil N. , Huang Yu‐Ling , Velusamy Arulmozhi , Liu Cheng‐Liang , Su Ting‐Yu , Jiang Xianyuan , Lin Jhih‐Min , Chen Ming‐Chou , Diau Eric Wei‐Guang 
Published: July 2024

AbstractThree functionalized thienopyrazines (TPs), TP‐MN (1), TP‐CA (2), and TPT‐MN (3) were designed and synthesized as self‐assembled monolayers (SAMs) deposited on the NiOx film for tin‐perovskite solar cells (TPSCs). Thermal, optical, electrochemical, morphological, crystallinity, hole mobility, and charge recombination properties, as well as DFT‐derived energy levels with electrostatic surface potential mapping of these SAMs, have been thoroughly investigated and discussed. The structure of the TP‐MN (1) single crystal was successfully grown and analyzed to support the uniform SAM produced on the ITO/NiOx substrate. When we used NiOx as HTM in TPSC, the device showed poor performance. To improve the efficiency of TPSC, we utilized a combination of new organic SAMs with NiOx as HTM, the TPSC device exhibited the highest PCE of 7.7 % for TP‐MN (1). Hence, the designed NiOx/TP‐MN (1) acts as a new model system for the development of efficient SAM‐based TPSC. To the best of our knowledge, the combination of organic SAMs with anchoring CN/CN or CN/COOH groups and NiOx as HTM for TPSC has never been reported elsewhere. The TPSC device based on the NiOx/TP‐MN bilayer exhibits great enduring stability for performance, retaining ~80 % of its original value for shelf storage over 4000 h.