bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fear of disease progression, self-management efficacy, and family functioning in patients with breast cancer: a cross-sectional relationship study
Authors: Zhuang Jiaru , Wang Yuan , Wang Shan , Hu Renjing , Wu Yibo , Chen Ling 
Published: July 2024

IntroductionFear of disease progression (FoP) has been identified as one of the most prevalent unmet needs among breast cancer patients in recent years. The aim of this study was to examine FoP in patients with breast cancer and explore its associations with demographic and clinical characteristics, self-management efficacy, and family functioning. We also aimed to create a clinically-relevant prediction model based off of these factors (i.e., a “nomogram”) to help identify patients’ probability of experiencing high FoP.MethodsA cross-sectional survey of breast cancer in patients at the Affiliated Hospital of Jiangnan University was conducted from June 2023 to February 2024. The study included the Demographic and Clinical Characteristics Questionnaire, the Fear of Disease Progression Scale (FoP-Q-SF), the Chinese Self-Management Efficacy Scale for Cancer Patients (C-SUPPH), and the Family Care Index Questionnaire (APGAR). Data analysis included descriptive statistics, independent-samples t-test, one-way ANOVA, Pearson correlation analysis, and multiple regression analysis. A nomogram was constructed based on multiple regression results and the model performance was evaluated.ResultsA total of 151 breast cancer patients were enrolled in the study. The mean (standard deviation) FoP score of the patients was 35.87 ± 9.24. The average score of C-SUPPH was 96.97 ± 17.29, and the average score of APGAR was 6.74 ± 2.98. Pearson correlation analysis showed that FoP was negatively correlated with self-management efficacy (r = −0.544, p &lt; 0.01) and family functioning (r = −0.730, p &lt; 0.01). Multiple regression analysis showed that age (B = −4.038), self-management efficacy (B = −0.085) and family functioning (B = −1.972) were significantly related to FoP, and together explained 36% of FoP variation (R2 = 0.360, F = 20.50, p &lt; 0.001). The nomogram of these variables showed satisfactory prediction performance [the Bootstrap Correction Consistency Index (C-index) = 0.872]. According to previous studies, a C-index of &gt;0.70 indicates that the model is acceptable.ConclusionWe found that greater fear of cancer progression (FoP) was associated with younger age, lower self-management efficacy and poorer family functioning in breast cancer patients. Based on these variables, our exploratory prediction model should be further investigated in order to help identify breast cancer patients who may be at highest risk of experiencing high FoP.
Determinants of thinness among school adolescents in Legehida district, Amhara region, north east Ethiopia: an unmatched case-control study
Authors: Ali Awol Assen , Adugna Dessalegn Tamiru , Ayele Wolde Melese , Tadesse Sisay Eshete , Mekonnen Tefera Chane , Wudu Muluken Amare 
Published: July 2024

BackgroundAdolescence is a critical stage of human growth and development, and adolescent nutritional status is a significant predictor of health outcomes. However, adolescents in developing countries, including Ethiopia, have received little attention from nutrition-related programs in recent decades. Consequently, malnutrition among adolescents is a widespread issue in these regions.ObjectiveThe study aimed to identify the determinants of thinness among school adolescents in the Legehida district of South Wollo Zone, Northeastern Ethiopia.MethodsA school-based, unmatched case-control study was conducted from January 20 to February 2, 2019. A total of 525 school-aged adolescents (175 cases and 350 controls) from the Legehida district were enrolled using a multistage sampling technique. Data were collected through interview-administered questionnaires and anthropometric measurements. EpiData version 3.1 was used for data entry, while Anthroplus software was employed for anthropometric measurement entry and analysis. The data were then exported to SPSS version 25 for further analysis. Bivariate and multivariable logistic regression analyses were performed to assess the determinants of adolescent thinness.ResultsIn this study, thinness among school adolescents was significantly associated with several factors: the absence of a latrine at home [AOR = 8.2, 95% CI (3.8, 8.17)], meal skipping per day [AOR = 3.1, 95% CI (1.2, 7.3)], inadequate consumption of fruits and vegetables [AOR = 7.5, 95% CI (3.9, 14.5)], having more than four household members [AOR = 13.6, 95% CI (7.1, 26)], and the consumption of unsafe water [AOR = 7.7, 95% CI (3.8, 15.6)].Conclusions and recommendationsThe absence of latrines and access to clean water, dietary factors, and family size emerged as significant contributors to adolescent thinness in this study. Addressing the nutritional challenges faced by adolescents will require collaborative efforts across sectors.
Spatially and temporally precise microbiome profiling in the small intestine using the SIMBA capsule with X-ray tracking
Authors: Wang Gang , Menon Sharanya , Wilsack Lynn , Rehak Renata , Lou Lawrence , Turbide Christian , Auger Jeremie , Tremblay Annie , Mathieu Olivier , Binda Sylvie , Tompkins Thomas A. , Bruehlmann Sabina , Andrews Christopher N. 
Published: July 2024

IntroductionFew minimally invasive options for sampling the small intestinal (SI) luminal fluid exist to study the SI microbiota in health and disease. To address the lack of tools and methods to study GI regions that are difficult to access, Nimble Science developed a fully autonomous and passive sampling method, the Small Intestine MicroBiome Aspiration (SIMBA™) capsule, for convenient, high-quality, and reliable sampling to study the diet-microbiota interactions in the SI. MethodsThe sealing efficacy and microbial DNA preservation capacity of the SIMBA capsules was first validated through in vitro simulation assays. Then, a clinical study was conducted with 20 healthy participants to validate the in vivo use of SIMBA capsules to reliably capture samples for SI microbiome analysis before and after an intervention (NCT04489329). Briefly, participants ingested the capsules at baseline and 7 days later, with a probiotic capsule containing a blend of L. rhamnosus R0011 and B. longum R0175. Following baseline SIMBA capsule ingestion, multiple low-dosage x-ray scans were performed to track the sampling location. Fecal samples corresponding with the baseline and intervention capsule were analyzed for comparison. ResultsThe SIMBA capsules’ performance in vitro demonstrated the potential for contamination-free sampling with preservation of the microbial communities. Within the clinical study, the capsules performed safely and reliably for collection of SI content. X-ray tracking confirmed that 97.2% of the capsules completed sample collection in the SI regions before reaching the colon. Importantly, our data showed that the capsules sampled in the right area of the intestines and that baseline SIMBA microbiome profile is significantly different from fecal microbiome profile. SIMBA successfully detected a concurrent probiotic intervention in the small intestine, which was not detectable using stool samples. DiscussionsThe high accuracy of sampling location and sealing efficacy of the SIMBA capsules makes them potentially useful research tools in clinical trials for studying diet-microbiota interactions in health and disease, and perhaps eventually for the clinical diagnosis of GI tract conditions affecting the SI such as SIBO.
Sws2 Gene Positively Regulates Melanin Production in Plectropomus leopardus Skin via Direct Regulation of the Synthesis of Retinoic Acid
Authors: Yu Haoran , Chen Huapeng , Wang Xinxin , Zhang Yichun , Tan Yafang , Wang Lei , Sun Junlong , Luo Jian , Song Feibiao 
Published: July 2024

Opsins are a class of transmembrane proteins encoded by opsin genes, and they play a variety of functional roles. Short wavelength-sensitive opsin 2 (sws2), one of the five classes of visual opsin genes, mainly senses blue light. Previous research has indicated that sws2 is essential for melanocyte formation in fish; however, its specific role in skin color differentiation remains to be elucidated. Here, we identified the sws2 gene in a prized reef-dwelling fish, Plectropomus leopardus. The full-length P. leopardus sws2 gene encodes a protein consisting of 351 amino acids, and exhibits substantial homology with other fish species. The expression of the sws2 gene was widespread across P. leopardus tissues, with high expression in eye and skin tissues. Through immunohistochemistry and in situ hybridization analyses, we discovered that the sws2 gene was primarily localized in the rod and cone cells of the retina, and epidermal cells of the skin. Furthermore, dsRNA interference was used for sws2 gene knockdown in living P. leopardus to elucidate its function in skin color differentiation. Black-color-related genes, melanin contents, and tyrosinase activity in the skin significantly decreased after sws2 knockdown (p < 0.05), but red-color-related genes and carotenoid and lutein contents significantly increased (p < 0.05). Retinoic acid injection produced the opposite results. Our results suggested that the sws2 gene influences P. leopardus skin color regulation by affecting vitamin synthesis and melanin-related gene expression levels. This study establishes a foundation for elucidating the molecular mechanisms by which sws2 regulates melanocyte formation in fish skin.
Qualitative evaluation of a molecular point-of-care testing study for influenza in UK primary care
Authors: Xie Charis Xuan , Hoang Uy , Smylie Jessica , Aspden Carole , Button Elizabeth , Okusi Cecilia , Byford Rachel , Ferreira Filipa , Anand Sneha , Agrawal Utkarsh , Inada-Kim Matthew , Clark Tristan , de Lusignan Simon 
Published: July 2024

Background
Influenza contributes to the surge in winter infections and the consequent winter pressures on the health service. Molecular point-of-care testing (POCT) for influenza may improve patient management by providing rapid and accurate clinical diagnosis to inform the timely initiation of antiviral therapy and reduce unnecessary admissions and antibiotics use.

Aim
To explore factors that influence the adoption or non-adoption of POCT in English general practices and provide insights to enable its integration into routine practice workflows.

Design & setting
A qualitative implementation evaluation was conducted in 10 general practices within the English national sentinel network (Oxford RCGP Research and Surveillance Centre), from April–July 2023.

Method
Using the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) framework, data collection and analysis were conducted across 10 practices. We made ethnographic observations of the POCT workflow and surveyed the practice staff for their perspectives on POCT implementation. Data were analysed using a mix of descriptive statistics, graphical modelling techniques, and framework analysis.

Results
Ethnographic observations identified the following two modes of POCT integration into practice workflow: (1) clinician POCT workflow, which typically involved batch testing owing to time constraints; and (2) research nurse or healthcare assistant POCT workflow, which was characterised by immediate testing of individual patients. Survey data indicated that most primary care staff considered the POCT training offered was sufficient and these practices were ready for change. Some participants agreed that there was the capacity and resources to integrate POCT into workflows. It was uncertain as to whether POCT required changes to organisational routines and processes.

Conclusion
General practices should demonstrate flexibility in the workflow and workforce they deploy to integrate POCT into routine clinical workflow.
Application of Artificial Intelligence Technologies in Neurology: A Literature Review
Authors: Чичановская Л.В. , Сороковикова Т.В. , Морозов А.М. , Ковальчук Ю.И. 
Published: July 2024

Современная клиническая практика требует интеграции и интерпретации постоянно растущих объемов клинических данных. Поэтому существует необходимость разработки эффективных способов обработки, анализа и синтеза больших объемов данных. Неврологи работают над пониманием функции биологических нейронных сетей, но искусственные нейронные сети и другие формы алгоритмов машинного обучения, вероятно, будут все чаще встречаться в клинической практике. Проводятся постоянные исследования, посвященные искусственному интеллекту в здравоохранении, и его потенциальное применение охватывает множество областей клинической медицины. Учитывая рост оцифровки медицинских записей, включая визуализацию, искусственный интеллект имеет хорошие возможности для анализа огромных объемов данных. Классическим статистическим методам не хватает возможности формировать прогнозы на основе больших неструктурированных наборов данных, которые содержат множество входных переменных и возможных ассоциаций. Напротив, искусственный интеллект превосходно выявляет закономерности на основе обширных и громоздких данных. На основе анализа сведений литературы были приведены примеры исследований с использованием технологий машинного обучения в неврологической практике.
Modern clinical practice requires the integration and interpretation of ever-growing volumes of clinical data. Therefore, there is a need to develop effective ways for processing, analyzing, and synthesizing large amounts of data. Neuroscientists are working to understand the function of biological neural networks, but artificial neural networks and other forms of machine learning algorithms are likely to become increasingly common in clinical practice. There is ongoing research on artificial intelligence in healthcare, and its potential applications cover many areas of clinical medicine. Given the increasing digitization of medical records, including visualization, artificial intelligence is well positioned to analyze huge amounts of data. Traditional statistical methods lack the ability for generating forecasts over large unstructured datasets containing numerous input variables and potential associations. On the contrary, artificial intelligence is excellent at identifying patterns based on extensive and cumbersome data. Based on the analysis of the literature data, examples of studies using machine learning technologies in neurological practice were given.
Granulomatous Diseases of the Central Nervous System
Authors: Рушкевич Ю.Н. , Павловская Т.С. , Золотухина М.В. , Лихачев С.А. , Гвищ Т.Г. , Антоненко Д.А. , Соловей Н.В. , Клюнчик С.Г. 
Published: July 2024

Современные методы нейровизуализации занимают ключевое место в диагностике гранулематозных заболеваний центральной нервной системы. Своевременное установление диагноза имеет решающее значение, поскольку назначение патогенетической терапии позволяет улучшить клинический исход и прогноз заболевания.
Modern methods of neuroimaging occupy a key place in the diagnosis of granulomatous diseases of the central nervous system. A timely diagnosis is of crucial importance, since the prescription of pathogenetic therapy can improve the clinical outcome and prognosis of the disease.
PELATIHAN PENGUATAN BUMDES DAN POTENSI DESA BAKKA BAKKA KEC.WONOMULYO KAB. POLEWALI MANDAR
Authors: Basri Basri , Malik Abdul , Irfandi Irfandi , Amirullah Amirullah , Hasyim Hasyim , Arliana Selvy , Armon Ariani , Mansur Mansur , Waslia Waslia , Safry Sarah , Triyanda Ayu , Nurhaeni Nurhaeni , Aras Faulyna , Welso Welso 
Published: July 2024

Pelatihan bumdes,yang di laksanakan oleh KKN PUMD didesa bakka bakka ini untuk dapat mengetahui bagai mana cara mengelolah potensi yang ada di desa bakka sebagai mana regulasi pemerintah desa nomor 2 tahun 2016.metode yang digunakan dengan pendekatan yang dilakukan secara kualitatif. Dengan adanya pelatihan bumdes dan penguatan potensi desa,di desa bakka bakka adalah untuk menggali potensi yang ada di dessa bakka bakka serta membantu seluruh kalangan masyarakat dan pengurus bumdes yang ada di desa tersebut untuk sama sama mengetahui seperti apa metode yang dilakukan dalam mengelolah potensi yang ada. dan dengan adanya pelatihan ini juga untuk menambah wawasan masyarakat tentang cara pengelolaan potensi desa dengan baik dan benar.dan ada pun potensi yang belom terkelolah dengan baik itu bisa terkelolah dengan cara memberikan metode yang baru untuk mengelolah potensi yang ada di desa tersebut. Kata kunci: potensi desa,bumdes,desa bakka bakka. voter's education
BIMBINGAN TEKNIS DAN PEMUTAKHIRAN TEKNOLOGI SMART CAMPUS
Authors: Kitta Ikhlas , Palantei Elyas , Dewiani Dewiani , Syafaruddin Syafaruddin , Manjang Salama , ARENI Intan Sari , Wardi Wardi 
Published: July 2024

Smart city mengacu pada konsep pengelolaan kota yang efisien, berkelanjutan, dan inovatif melalui pemanfaatan teknologi ICT terkini. Penggunaan sensor, big data, dan kecerdasan buatan (AI) memungkinkan pemantauan real-time terhadap lalu lintas, polusi udara, penggunaan energi, dan layanan publik lainnya. Tujuan utama dari konsep smart city adalah meningkatkan kualitas hidup warga. Pada sisi lainnya, teknologi smart campus adalah konsep yang mengintegrasikan teknologi ICT canggih ke dalam lingkungan universitas atau institusi pendidikan tinggi. Melalui teknologi smart campus, pendidikan tinggi tidak lagi terbatas pada ruang kelas fisik konvensional. Penggunaan e-learning, aplikasi mobile, dan platform pembelajaran online memungkinkan mahasiswa untuk mengakses materi pelajaran kapan saja, dan di mana saja. Selain itu, teknologi ini juga dapat digunakan untuk meningkatkan pengalaman mahasiswa di luar kelas, seperti sistem manajemen informasi akademik yang terintegrasi, dan pusat kegiatan ekstrakurikuler yang terotomatisasi. Dalam rangka mendukung konsep smart city dan smart campus tersebut, Universitas Hasanuddin hadir memberikan solusi dan inovasi untuk menunjang proses belajar yang lebih inovatif dan atraktif di kampus. Dengan berbagai peralatan smart campus yang telah diriset, Universitas Hasanuddin juga mengajak perguruan tinggi lainnya untuk mulai beralih kedalam sistem smart campus. Terdapat peningkatan pemahaman sekitar 67% dari peserta kegiatan bimbingan teknis dan pemutakhiran teknologi smart campus yang berkolaborasi dengan pihak IAIN Bone. Data statistik ini mengkonfirmasi aspek urgensi kegiatan sejenis untuk secara berkelanjutan ditradisikan pada masa-masa yang akan datang.
PELATIHAN PRODUKSI KERIPIK SINGKONG DAN PAKAN TERNAK KEPADA PEMUDA DESA LAMATUKA LEMBATA
Authors: Tukan Gerardus Diri , Pote Lodowik Landi , Taek Maximus Markus , Lengari Helena Hapa , Dwiputri Tukan Amandha Victoria , Wokal Monika Woli , Lasar Maria Wilhelmina , Lalong Paulus Risan Funan 
Published: July 2024

Kegiatan pengabdian yang dilakukan ini bertujuan mengajak generasi muda desa Lamatuka dan memberikan pengetahuan serta keterampilan untuk mengoptimalkan potensi ubi kayu yang ada di desa tersebut dan desa-desa tetangga menjadi produk yang bernilai jual, yaitu sebagai keripik singkong, tepung kanji dan pakan ternak yang bergizi. Produksi pakan ternak bergizi untuk mendukung pengembangan usaha ternak babi oleh masyarakat di desa tersebut. Metode kegiatan yaitu praktek produksi. Umbi singkong dikupas dan diparut. Parutan singkong diperas. Ekstrak perasan didiamkan untuk produksi tepung tapioca. Residu singkong parutan ditempelkan pada bagian belakang piring kaleng dan dikukus, dikeringkan, digoreng serta diberi perasa, dikemas sebagai produk keripik. Limbah berupa potongan singkong dan kulit umbi singkong, dicacah dan difermentasi dengan larutan EM4 yang dicampur dengan gula pasir sebagai nutrisi bagi pertumbuhan mikroba pengurai, dan disimpan dalam ruang kedap udara selama delapan hari. Hasil yang diperoleh yaitu keripik singkong kemasan terdiri dari dua rasa yaitu manis pedas dan rasa original. Dihasilkan pula tepung tapioca. Tiap 1 kg singkong mentah menghasilkan rata-rata 6 kg keripik kering. Fermentasi terhadap potongan singkong dan kulit umbi singkong, berlangsung selama delapan hari dan dihasilkan pakan ternak yang memiliki bau asam wangi. Pakan ternak yang dihasilkan tersebut diberikan kepada hewan ternak babi, dan aman dikonsumsi.
PENINGKATAN PENGHASILAN MASYARAKAT DESA PATAMBANUA TERHADAP BUDIDAYA KOPI
Authors: Basri Basri , Angraeni Irma 
Published: July 2024

Tujuan program ini antara lain untuk mengetahui tingkat pendapatan masyarakat petani kopi dan untuk mengetahui peran petani terhadap peningkatan pendapatan petani Kopi di Desa Patambanu. Program Unasman Membangun Desa (PUMD) telah dilaksanakan di Desa Patambanua selama kurang lebih 50 hari. Berbagai program telah dilaksanakan,kegiatan PUMD yang telah dilaksanakan dimulai dengan oservasi desa, perencanaan program, konsultasi program dengan pihak desa dan DPL dan pelaksanaan program yang direncanakan. Kegiatan PUMD yang dilakukan meliputi tahap persiapan, pelatihan adaptasi iklim dan pelaksanaan pelatihan budidaya kopi. Salah satu program yang dilakukan selama PUMD, berupa pelatihan yang dilaksanakan di kantor Desa dan dusun-dusun yang jauh dari pusat desa dengan mengundang warga sekitar khususnya para petani kopi agar pengetahuan tentang budidaya kopi dapat meningkat sesuai prinsip
PENYULUHAN CEGAH STUNTING CIPTAKAN GENERASI SEHAT, CERDAS, AKTIF DAN PRODUKTIF DIDESA BAKKA-BAKKA
Authors: Muthmainnah Muthmainnah , Nurhaeda Nurhaeda , DheaAdelia DheaAdelia , Irmayanti Ade , Taufik Gibran , Mahandika Muh.isra , Faiz fauwas Andi muh 
Published: July 2024

stunting merupakan kondisi gagal tumbuh pada anak yang disebabkan karena kekurangan gizi dalam jangka waktu yang panjang. Balita yang menderita penyakit stunting seringkali dikenali dengan bentuk tubuhnya yang jauh lebih pendek atau kerdil jika dibandingkan dengan tinggi badan anak se-usia nya. Berdasarkan riset kesehatan dasar kementrian kesehatan tahun 2018 menunjukan bahwa 1 dari 3 anak di Indonesia mengidap penyakit stunting. Kondisi ini tentu menjadi sebuah masalah besar bagi kita semua, bukan hanya PR bagi pemerintah ataupun tenaga medis melainkan juga masyarakat luas terutama ibu rumah tangga untuk lebih memperhatikan asupan gizi anak nya. Oleh sebab itu, tujuan kami mengadakan penyuluhan bahaya pernikahan dini adalah sebagai salah satu upaya pencegahan angka stunting di wilayah Desa Bakka-Bakka. Karena seperti yang telah kita ketahui, salah satu faktor penyebab stunting adalah pernikahan di usia dini. Untuk metode pelaksanaan dari kegiatan ini berupa penyuluhan mengenai pencegahan stunting dan pernikahan dini dengan remaja dan ibu hamil. Kegiatan penyuluhan mendapat dukungan dari bidan setempat, puskesmas wonomulyo dan juga pemerintah Desa Bakka-Bakka. Kegiatan ini telah berjalan dengan baik dan lancar. Kesimpulan : pernikahan dini berdampak terhadap pola asuh yang kurang memadai sebagai akibat keterbatasan pengetahuan sang ibu serta berpotensi timbulnya perebutan gizi antara ibu dengan janin semasahamil. Oleh sebab itu, pernikahan dinidianggap menjadi salah satu faktor penyebab timbulnya stunting
Bulk photovoltaic effect in Cu-doped LiNbO3 single crystals with controlled oxidation state
Authors: Matsuo Hiroki , Sato Tomoki , Noguchi Yuji 
Published: July 2024

Abstract
We investigate the bulk photovoltaic (PV) effect of Cu-doped LiNbO3 single crystals with various oxidation states of Cu. The Cu-doped samples exhibit the PV response under below-bandgap excitation, and the onset of photocurrent shifts depending on partial oxygen pressures (pO2) during the annealing treatment. Open-circuit voltages (V
oc) under simulated sunlight (AM 1.5 G) illumination are changed by pO2, and crystals annealed at pO2 = 1.0 × 10−10 atm exhibit the highest V
oc of 1700 V. Moreover, density functional theory (DFT) calculations for Cu-doped LiNbO3 cells with Cu2+ on the Li site and the Nb site indicate that half-filled gap states derived from 3d orbitals of Cu are formed within the bandgap. Based on Glass coefficients obtained by the analyses of polarization angle-dependent photocurrent densities and the DFT calculations, we consider that Cu2+ on the Li site is the major active site for the generation and separation of electron–hole pairs under visible light at hν = 2.4 eV.