bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stochastic model for estimating the risk of transfusion‐transmitted hepatitis B in Vietnam
Authors: Viet L. , Husebekk A. , Husum H. , Skjerve E. 
Published: June 2013

SUMMARYBackground and objectiveTransfusion‐transmitted hepatitis B virus (HBV) infection may originate from hepatitis B surface antigen (HBsAg) false‐negative blood donors, HBsAg negative and anti‐HBc positive blood donors and blood donors with both tests negative. HBV DNA may be present in all these cases and blood may be infectious. The aim of the study was to estimate the risk of transfusion‐transmitted HBV in Vietnam using a stochastic Monte Carlo model.MethodsA cross‐sectional study of HBV prevalence in 1200 potential blood donors in rural Vietnam is used as basis for the Monte Carlo model together with expert panel estimates of occult hepatitis B infection (OBI) prevalence in blood donors.ResultsWith 1 000 000 blood donors running in the model, the potential OBI ranged from 658 to 747 blood units per million at 5 percentile and from 1342 to 2507 blood units per million at 95 percentile resulting in the risk of post‐transfusion hepatitis ranging from 66 to 250 blood units per million assuming that risk of post‐transfusion from potential OBI is 10%. Using the manufacturer's HBsAg sensitivity, the mean rate of blood units per million donations having false‐negative HBsAg results was 298 (5–95 percentile: 14–893). When the test sensitivity was set lower, false‐negative tests was observed at a mean of 1087 per million (5–95 percentile: 762–3220). The fraction of potential OBI donors increased with the increasing age in both genders.ConclusionCurrent HBsAg screening in Vietnam is insufficient in eliminating the risk of transfusion‐transmitted HBV infection. The major risk factors are HBsAg false‐negative results and OBI. Increased test sensitivity and locally validated HBsAg assays are recommended.
Draft Genome Sequence of the Pediocin-Encoding Biopreservative and Biocontrol Strain Pediococcus acidilactici D3
Authors: Sturino Joseph M. , Rajendran Mahitha , Altermann Eric 
Published: June 2013

ABSTRACT

We describe a draft genome sequence for
Pediococcus acidilactici
strain D3, a component of multistrain commercial cultures with biopreservative and biocontrol properties in food-based applications. Strain D3 encodes at least one antimicrobial peptide, pediocin AMPd3. The AMPd3-encoding operon exhibits high sequence similarity to the archetype pediocin, PA-1, encoded by
P. acidilactici
PAC 1.0.
Draft Genome Sequence of Bacillus atrophaeus UCMB-5137, a Plant Growth-Promoting Rhizobacterium
Authors: Chan Wai Yin , Dietel Kristin , Lapa Svitlana V. , Avdeeva Lilija V. , Borriss Rainer , Reva Oleg N. 
Published: June 2013

ABSTRACT

Bacillus atrophaeus
UCMB-5137 shows an extraordinary activity in root colonization and plant and crop protection. Its draft genome sequence comprises 21 contigs of 4.11 Mb, harboring 4,167 coding sequences (CDS). The genome carries several genes encoding antimicrobial lipopeptides and polyketides. Multiple horizontally acquired genes of possible importance for plant colonization were also found.
Draft Genome Sequence of Vibrio parahaemolyticus V110, Isolated from Shrimp in Hong Kong
Authors: Liu Ming , Chen Sheng 
Published: June 2013

ABSTRACT

We report the whole-genome sequence of a
tdh
- and
trh
-negative
Vibrio parahaemolyticus
strain, V110, from shrimp. The major difference of V110 from clinical strains was its lack of the type III secretion system T3SS2, a key component of virulence. Further sequence comparison can shed light on the pathogenesis of
V. parahaemolyticus
.
Draft Genome Sequence of Rhodococcus rhodnii Strain LMG5362, a Symbiont of
Rhodnius prolixus
(Hemiptera, Reduviidae, Triatominae), the Principle Vector of Trypanosoma cruzi
Authors: Pachebat Justin A. , van Keulen Geertje , Whitten Miranda M. A. , Girdwood Susan , Del Sol Ricardo , Dyson Paul J. , Facey Paul D. 
Published: June 2013

ABSTRACT

We report the 4,385,577-bp high-quality draft assembly of the bacterial symbiont
Rhodococcus rhodnii
strain LMG5362, isolated from the gut of
Rhodnius prolixus
(Hemiptera, Reduviidae, Triatominae), the principle vector of the protozoan
Trypanosoma cruzi
, the etiological agent of Chagas disease. This sequence might provide useful information for subsequent studies of the symbiotic relationship between
Rd. prolixus
and
Rc. rhodnii
, while also providing a starting point for the development of biotechnological applications for the control of
Rd. prolixus
.
Genome Sequence of the Pectobacterium atrosepticum Strain CFBP6276, Causing Blackleg and Soft Rot Diseases on Potato Plants and Tubers
Authors: Kwasiborski Anthony , Mondy Samuel , Beury-Cirou Amélie , Faure Denis 
Published: June 2013

ABSTRACT

Pectobacterium atrosepticum
strain CFBP6276 is a pectinolytic enterobacterium causing blackleg and soft rot of the stem and tuber of
Solanum tuberosum
. Its virulence is under the control of quorum sensing, with
N
-acylhomoserine lactones as communication signals. Here, we report the genome sequence of
P
.
atrosepticum
strain CFBP6276.
Draft Genome Sequence of Aeromonas molluscorum Strain 848T
T
, Isolated from Bivalve Molluscs
Authors: Spataro Nino , Farfán Maribel , Albarral Vicenta , Sanglas Ariadna , Lorén J. Gaspar , Fusté M. Carmen , Bosch Elena 
Published: June 2013

ABSTRACT

We report here the draft genome sequence of
Aeromonas molluscorum
848T, the type strain of this
Aeromonas
species, which was isolated from wedge shells (
Donax trunculus
) obtained from a retail market in Barcelona, Spain, in 1997.
Raman spectroscopy in heavy-mineral studies
Authors: Andò Sergio , Garzanti Eduardo 
Published: June 2013

Abstract
Raman spectroscopy is an innovative tool with tremendous potential, serving as a fundamental complement to a variety of provenance methods including heavy-mineral analysis and detrital geochronology. Because of its accuracy, efficiency and versatility, the results of the Raman technique are indispensable for fully reliable identification of heavy minerals in grain mounts or thin sections. Thorny long-standing problems that cannot be solved confidently with a polarizing microscope alone, such as the determination of opaque and altered heavy minerals, of detrital grains as small as a few microns, or of colourless crystals with uncertain orientation and rounded morphology, can finally be addressed. Although the method can be highly automatized, the full ability and experience of the operator is required to combine Raman data with the optical information obtained under the microscope on the same grains, which is essential for the efficient application of the method in provenance studies. This article provides exemplary Raman spectra useful for the comparison and determination of over 70 different opaque and transparent heavy-mineral species commonly found in sediments, conveying specific information on the genesis of their source rocks, and thus is particularly useful in provenance diagnoses and palaeotectonic reconstructions.

Supplementary material:

Detailed information on the lasers used and the origin of the analysed minerals is available at
http://www.geolsoc.org.uk/SUP18615
.
Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability
Authors: Matsumoto Hiroaki , Yamamoto Yoshiaki , Shiota Masaki , Kuruma Hidetoshi , Beraldi Eliana , Matsuyama Hideyasu , Zoubeidi Amina , Gleave Martin 
Published: June 2013

Abstract
Although androgen receptor (AR) pathway inhibitors prolong survival in castrate-resistant prostate cancer (CRPC), resistance rapidly develops and is often associated with increased stress-activated molecular chaperones like clusterin (CLU) and continued AR signaling. Because adaptive pathways activated by treatment facilitate development of acquired resistance, cotargeting the stress response, activated by AR inhibition and mediated through CLU, may create conditional lethality and improve outcomes. Here, we report that CLU is induced by AR antagonism and silencing using MDV3100 and antisense, respectively, to become highly expressed in castrate- and MDV3100-resistant tumors and cell lines. CLU, as well as AKT and mitogen-activated protein kinase (MAPK) signalosomes, increase in response to MDV3100-induced stress. Mechanistically, this stress response is coordinated by a feed-forward loop involving p90rsk (RPS6KA)-mediated phosphoactivation of YB-1 with subsequent induction of CLU. CLU inhibition repressed MDV3100-induced activation of AKT and MAPK pathways. In addition, when combined with MDV3100, CLU knockdown accelerated AR degradation and repressed AR transcriptional activity through mechanisms involving decreased YB-1–regulated expression of the AR cochaperone, FKBP52. Cotargeting the AR (with MDV3100) and CLU (with OGX-011) synergistically enhanced apoptotic rates over that seen with MDV3100 or OGX-011 monotherapy and delayed CRPC LNCaP tumor and prostate-specific antigen (PSA) progression in vivo. These data indicate that cotargeting adaptive stress pathways activated by AR pathway inhibitors, and mediated through CLU, creates conditional lethality and provides mechanistic and preclinical proof-of-principle to guide biologically rational combinatorial clinical trial design. Cancer Res; 73(16); 5206–17. ©2013 AACR.
Lysine Acetyltransferase PCAF Is a Key Regulator of Arteriogenesis
Authors: Bastiaansen Antonius J.N.M. , Ewing Mark M. , de Boer Hetty C. , van der Pouw Kraan Tineke C. , de Vries Margreet R. , Peters Erna A.B. , Welten Sabine M.J. , Arens Ramon , Moore Scott M. , Faber James E. , Jukema J. Wouter , Hamming Jaap F. , Nossent A. Yaël , Quax Paul H.A. 
Published: June 2013

Objective—
Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional coactivator p300-CBP–associated factor (PCAF) has histone acetylating activity and promotes transcription of multiple inflammatory genes. Because arteriogenesis is an inflammation-driven process, we hypothesized that PCAF acts as multifactorial regulator of arteriogenesis.

Approach and Results—

After induction of hindlimb ischemia, blood flow recovery was impaired in both PCAF
−/−
mice and healthy wild-type mice treated with the pharmacological PCAF inhibitor Garcinol, demonstrating an important role for PCAF in arteriogenesis. PCAF deficiency reduced the in vitro inflammatory response in leukocytes and vascular cells involved in arteriogenesis. In vivo gene expression profiling revealed that PCAF deficiency results in differential expression of 3505 genes during arteriogenesis and, more specifically, in impaired induction of multiple proinflammatory genes. Additionally, recruitment from the bone marrow of inflammatory cells, in particular proinflammatory Ly6C
hi
monocytes, was severely impaired in PCAF
−/−
mice.

Conclusions—
These findings indicate that PCAF acts as master switch in the inflammatory processes required for effective arteriogenesis.
Asymmetric Dimethylarginine in Response to Recombinant Tissue-Type Plasminogen Activator and Erythropoietin in Acute Stroke
Authors: Worthmann Hans , Martens-Lobenhoffer Jens , Joumaah Majed , Li Na , Lichtinghagen Ralf , Hecker Hartmut , Kielstein Jan T. , Ehrenreich Hannelore , Bode-Böger Stefanie M. , Weissenborn Karin 
Published: June 2013

Background and Purpose—
In the German Multicenter Erythropoietin (EPO) Stroke Trial, patients not receiving thrombolysis most likely benefited from EPO on clinical recovery, whereas a combination of rtPA and EPO was associated with increased mortality. We investigated whether the combination of rtPA and EPO increased release of the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA), and thereby potentially deteriorated ischemic stroke outcome, as suggested from experimental data.

Methods—
ADMA was determined in serum samples from 90 patients of the German Multicenter EPO Stroke Trial taken at days 1 (within 6 hours after symptom onset), 2, 3, 4, and 7 after stroke using high-performance liquid chromatography–tandem mass spectrometry. ADMA was analyzed for the different treatment groups (EPO, n=25; placebo, n=30; rtPA+placebo, n=18; EPO+rtPA, n=17). Clinical outcome was expressed as difference between National Institutes of Health Stroke Scale at baseline and 90 days.

Results—

ADMA levels significantly increased during the observation time in EPO, EPO+rtPA, and placebo groups (
P
<0.05). A treatment effect on ADMA levels was revealed by repeated measures ANOVA only in the rtPA+placebo group (
P
=0.027). Here, ADMA levels were decreased compared with the placebo group (
P
<0.05). Both the EPO and the rtPA+placebo groups in the Hannover subgroup of the EPO trial had better outcome than the placebo group (
P
<0.05).

Conclusions—
Our data underscore the potential benefit of EPO in ischemic stroke. The hypothesis from experimental data, that EPO treatment increases ADMA in stroke patients, was disproved. Further studies are needed to clarify whether decreased ADMA might contribute to therapeutic rtPA effects.
Permutations of Sovereignty in the Priestly Tradition
Authors: Brett Mark G. 
Published: June 2013

Abstract
According to P and H, Israelites can in some respects be seen as “sojourners” (גרים) not just in foreign lands but also in the land given to Abraham’s seed. As one would expect, Israelites are also viewed as citizens in their own land, yet ironically this is affirmed in H passages such as Lev. 24:22 and Exod. 12:49 which call for equality between natives and immigrants. The paper suggests that P and H are engaged in a debate with the Deuteronomistic traditions about the significance of political sovereignty and citizenship. The priestly writers mimic imperial symbolism and imply that the “many nations” descended from Abraham (Gen. 17:4), and the “assembly of nations” descended from Jacob-Israel (Gen. 35:11), would embody an imperial rather than national sovereignty.
A Suggestion Regarding the Meaning of 2 Kings 17:9 and the Composition of 2 Kings 17:7-23
Authors: Goldstein Ronnie 
Published: June 2013

Abstract
This article adduces Akkadian idioms to explain three formulations in 2 Kgs 17:9-11 which differ from the standard Deuteronomistic phraseology employed in 2 Kgs 17:7-23. The awkward Hebrew phrase ויחפאו. . . דברים is interpreted as a loan from Akkadian hepû + dibbu = “to break an agreement”, the following expression דברים אשר לא כן compared with the Akkadian dibbu ša lā kinnu = “disloyal talk”, and the ending of v. 11 understood in the light of an Akkadian idiom. On this analysis, vv. 9-11 appear to be composed of two strata, the original core—composed during the Neo-Assyrian period—and a later Deuteronomistic redaction which reinterpreted the initial text. The former can be understood as a very early theological response to the destruction of Samaria and Assyrian imperial claims regarding its fall which utilizes Neo-Assyrian covenantal terminology to describe the relationship between the God of Israel and His people.
The Roots of Anger: An Economic Perspective on Zephaniah’s Oracle Against the Philistines
Authors: Welch Eric Lee 
Published: June 2013

Abstract
The superscription of the book of Zephaniah places the composition in the 7th century BCE, during the reign of King Josiah of Judah. While some scholars support a monarchic date for composition on the grounds of geopolitical details, others have accepted the book as a post-monarchic composition, in which geopolitical details are merely functions of literary techniques. Critical in the discussions of date and historicity are the oracles found in the book’s second chapter. This essay examines the introductory poem found in Zeph 2:4 and argues that the oracle is representative of 7th century Judean sentiments toward the city of Ekron because of a specific pun, which should be read in light of the city’s impressive olive oil industry dating to the 7th century BCE.
The Structure and Substance of Numbers 15
Authors: Baden Joel S. 
Published: June 2013

Abstract
Numbers 15 has long been seen in scholarship as a vaguely haphazard collection of disparate legal elements, with few obvious connections between them. Although some attempts have been made to find a thematic thread linking the various parts of the chapter, there has been little consensus on how best to understand the rationale behind the location and grouping of these legal passages or their particular order. This paper will make a new suggestion regarding the means by which Numbers 15 came to have its canonical shape.
The Righteous Gentile Interjects (James 2:18-19 and Romans 2:14-15)
Authors: Heath Jane 
Published: June 2013

Abstract
Jas 2:18-19 is at the heart of James’ famous (or, to some, infamous) argument about faith and works, but it defies definitive interpretation due to combined difficulties in punctuation and in tracing the literary continuity in James’ argument. This essay approaches the problematic passage in the context of James’ literary intertextuality with Paul. It suggests that the enigmatic objector in James is one of Paul’s righteous gentiles (Rom 2:14-15), who lumps James and his Jewish Christian ‘brothers’ together in charging them with hypocrisy (cf. Rom 2:17-23). James artfully gives this gentile Christian voice to strengthen his own argument, for an audience already alerted to his rich intertextuality with Paul.
Geographic Mobility as a System of Power Relations Inside Business Networks
Authors: Gherardi Laura , Pierre Philippe 
Published: June 2013

Abstract
This article focuses on the capacity of business élites to be ubiquitous—present on different scenes, geographically far from one another, simultaneously through the means of the mobility (and immobility) of other people who replace them. Based on interviewers with a sample of 52 people from three French multinationals we find that for many business managers, mobility appears to be more an imperative dictated by their role than a choice. For them an ambiguous interpretation of mobility occurs that fluctuates between it being viewed as a resource and a cost, a reward and a trial. At the same time their mobility facilitates differential accumulation of informational capital and social capital for their superiors.
Upper-Ocean Salinity Variability in the Tropical Pacific: Case Study for Quasi-Decadal Shift during the 2000s Using TRITON Buoys and Argo Floats
Authors: Hasegawa Takuya , Ando Kentaro , Ueki Iwao , Mizuno Keisuke , Hosoda Shigeki 
Published: June 2013

Abstract
Upper-ocean salinity variation in the tropical Pacific is investigated during the 2000s, when Triangle Trans-Ocean Buoy Network (TRITON) buoys and Argo floats were deployed and more salinity data were observed than in previous periods. This study focuses on upper-ocean salinity variability during the warming period of El Niño–Southern Oscillation (ENSO)-like quasi-decadal (QD)-scale sea surface temperature anomalies over the central equatorial Pacific (January 2002–December 2005; hereafter “warm QD phase”). It is shown that strong negative salinity anomalies occur in the western tropical Pacific and the off-equatorial Pacific in the upper ocean at depths less than 80 m, showing a horseshoe-like pattern centered at the western tropical Pacific during the warm QD phase. TRITON mooring buoy data in the western equatorial Pacific show that low-salinity and high-temperature water could be transported eastward from the western equatorial Pacific to the central equatorial Pacific during the warm QD phase. Similar patterns, but with the opposite sign of salinity anomalies, appear in the cold QD phase during January 2007–December 2009 with negative sea surface temperature anomalies over the central equatorial Pacific. It is suggested that effects from zonal salinity advection and precipitation could contribute to the generation of the salinity variations in the western equatorial Pacific for QD phases during the 2000s. On the other hand, the contribution of meridional salinity advection is much less than that of zonal salinity advection. In addition, El Niño Modoki and La Niña events could affect salinity changes for warm and cold QD phases via interannual-scale zonal salinity advection variations in the western equatorial Pacific during the 2000s.
Possible Root Causes of Surface Westerly Biases over the Equatorial Atlantic in Global Climate Models
Authors: Zermeño-Diaz David M. , Zhang Chidong 
Published: June 2013

Abstract
Most global climate models (GCMs) suffer from biases of a reversed zonal gradient in sea surface temperature (SST) and weak surface easterlies (the westerly bias) in the equatorial Atlantic during boreal spring. These biases exist in atmospheric GCMs (AGCMs) and are amplified by air–sea interactions in atmospheric–oceanic GCMs. This problem has persisted despite considerable model improvements in other aspects. This study proposes a hypothesis that there are two possible root causes for the westerly bias. The first is insufficient lower-tropospheric diabatic heating over Amazonia. The second is erroneously weak zonal momentum flux (entrainment) across the top of the boundary layer. This hypothesis is based on a scale analysis of a simple model for a well-mixed equatorial boundary layer and diagnoses of simulations from eight AGCMs. Severe westerly biases in AGCMs tend to occur when the diabatic heating at low levels (850–700 hPa) over Amazonia is too weak. Deficient low-level diabatic heating weakens the zonal gradient in sea level pressure along the Atlantic equator, introducing westerly biases. In addition, westerly biases may also occur when easterly momentum flux due to entrainment is underestimated.
System-level change in mental health services in North Wales: An observational study using systems thinking
Authors: Evans S , Huxley PJ , Maxwell N , Huxley KLS 
Published: June 2013

Purpose: To describe changes to mental health services using systems thinking. Method: Structured standardized quality of life assessment (Manchester Short Quality of Life Assessment: MANSA) was used to establish service user priorities for changes to service provision (part of a process known as check in systems thinking). Current service performance in these priority areas was identified, and changes to service arrangements were planned, implemented and monitored by task and finish (T&F) groups (making use of a process known as flow in systems thinking). Results: 81 MANSA assessments were completed at the check stage (by NM). Work finances and leisure activities emerged as service user priority areas for change, and T&F groups were established with representation of all sectors and service users. Ways to make improvements were observed, planned and implemented by T&F groups (the flow stage). Conclusion: The systems approach reveals how services and quality of life have been changed for patients in Wrexham. Further generalizable research is needed into the potential benefits of using systems thinking in mental health service evaluation.
‘I beg you to tear up my letters...’ Nikos Skalkottas’s last years in Berlin (1928-33)
Authors: Thornley John 
Published: June 2013

AbstractNikos Skalkottas (1904-49), the Greek pupil of Schoenberg, was one of the greatest and most prolific atonal and twelve-note composers of the twentieth century, though unrecognised in Athens during his lifetime. The fifty-six letters that he wrote to his patron Manolis Benakis illuminate Skalkottas’s life and his music, the financial and emotional difficulties leading to his enforced departure from Berlin, his aesthetic viewpoint, his opinions on Greece and its musical life, and his reasons for composing the popular ‘36 Greek Dances’. This is the first published account of this important documentary source.