bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of rice Allene Oxide Cyclase mutants and the function of jasmonate for defence against Magnaporthe oryzae
Authors: Riemann Michael , Haga Ken , Shimizu Takafumi , Okada Kazunori , Ando Sugihiro , Mochizuki Susumu , Nishizawa Yoko , Yamanouchi Utako , Nick Peter , Yano Masahiro , Minami Eiichi , Takano Makoto , Yamane Hisakazu , Iino Moritoshi 
Published: January 2013

SummaryTwo photomorphogenic mutants of rice, coleoptile photomorphogenesis 2 (cpm2) and hebiba, were found to be defective in the gene encoding allene oxide cyclase (OsAOC) by map‐based cloning and complementation assays. Examination of the enzymatic activity of recombinant GST–OsAOC indicated that OsAOC is a functional enzyme that is involved in the biosynthesis of jasmonic acid and related compounds. The level of jasmonate was extremely low in both mutants, in agreement with the fact that rice has only one gene encoding allene oxide cyclase. Several flower‐related mutant phenotypes were observed, including morphological abnormalities of the flower and early flowering. We used these mutants to investigate the function of jasmonate in the defence response to the blast fungus Magnaporthe oryzae. Inoculation assays with fungal spores revealed that both mutants are more susceptible than wild‐type to an incompatible strain of M. oryzae, in such a way that hyphal growth was enhanced in mutant tissues. The level of jasmonate isoleucine, a bioactive form of jasmonate, increased in response to blast infection. Furthermore, blast‐induced accumulation of phytoalexins, especially that of the flavonoid sakuranetin, was found to be severely impaired in cpm2 and hebiba. Together, the present study demonstrates that, in rice, jasmonate mediates the defence response against blast fungus.
Identification of Common Mechanisms by Which Human and Mouse Cytomegalovirus Seven-Transmembrane Receptor Homologues Contribute to
In Vivo
Phenotypes in a Mouse Model
Authors: Farrell Helen E. , Abraham Alexander M. , Cardin Rhonda D. , Mølleskov-Jensen Ann-Sofie , Rosenkilde Mette M. , Davis-Poynter Nicholas 
Published: January 2013

ABSTRACT
The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and -independent pathways contribute to the latency phenotypes. A novel M33-dependent replication phenotype in cultured bone marrow macrophages is also described.
Fault detection and estimation for non-Gaussian stochastic systems with time varying delay
Authors: Hu Kai , Song AiGuo , Wang WeiLiang , Zhang Yingchao , Fan Zhiyong 
Published: January 2013

Abstract
In this paper, fault detection and estimation problem is studied for non-Gaussian stochastic systems with time varying delay. A new approach based on the output probability density function (PDF) and observers technique to detect and estimate time varying faults is presented. Some slack variables and scalars are introduced to design observers’ parameters, which can provide more degrees of freedom. A particle distribution example is given to illustrate the design procedures, and the simulation results show the performance of the proposed approaches.
Crystal structure of 1H-imidazo(4,5-f)-1,10-phenanthroline-terphenyl- 2,5,2',5'-tetracarboxylic acid monohydrate (2:1:1), (C13H8N4)2·(C22H14O8)·(H2O), C48H32N8O9
Authors: Chang Xin-Hong , Li Guang-Feng 
Published: January 2013

Abstract C48H32N8O9, monoclinic, C2/c (no. 15), a = 26.901(8) Å, b = 7.068(2) Å, c = 20.247(6) Å, β = 93.796(3)°, V = 3841.2 Å3, Z = 4, Rgt(F) = 0.0689, wRref(F2) = 0.1822, T = 296 K.
Crystal structure of dipyrido(3,2-a:2',3'-c)phenazine-terphenyl-2,5,2',5'- tetracarboxylic acid (2:1), (C18H10N4)2·(C22H14O8), C58H34N8O8
Authors: Chang Xin-Hong , Li Guang-Feng 
Published: January 2013

Abstract C58H34N8O8, monoclinic, C2/c (no. 15), a = 28.265(6) Å, b = 10.004(2) Å, c = 15.748(3) Å, β = 92.128(2)°, V = 4449.9 Å3, Z = 4, Rgt(F) = 0.0614, wRref(F2) = 0.2012, T = 296 K.
Crystal structure of quininium-trichloro-zinc(II), ZnCl3(C20H25N2O2), C20H25Cl3N2O2Zn
Authors: Kang Jaeun , Yun Hoseop , Do Junghwan 
Published: January 2013

Abstract C20H25Cl3N2O2Zn, orthorhombic, P212121 (no. 19), a = 7.673(2) Å, b = 11.485(2) Å, c = 24.655(5) Å, V = 2172.6 Å3, Z = 4, Rgt(F) = 0.0487, wRref(F2) = 0.1381, T = 296 K.
Crystal structure of diethyl 5-nitro-isophthalate, C12H13NO6
Authors: Zou Pei , Wu Hao , Xie Min-Hao , Liu Ya-Ling , Shen Yong-Jia 
Published: January 2013

Abstract C12H13NO6, orthorhombic, Pca21 (no. 29), a = 31.762(7) Å, b = 4.1073(9) Å, c = 19.363(4) Å, V = 2526.0 Å3, Z = 8, Rgt(F) = 0.0603, wRref(F2) = 0.1487, T = 163 K.
The simple man: The consumption behavior of the principled life
Authors: McGinnis Lee Phillip , Frendle Angela M. , Gentry James W. 
Published: January 2013

ABSTRACTIn this study, we analyze the Simple Man, a label for those men who have above‐average means in education, household income, or net worth but who consume inconspicuously and modestly below their means. We interviewed 27 men in the Northwest, Midwest, Southeast and Northeast regions of the United States and found that these men have highly individualistic identities and backgrounds yet appear to stray from products that separate them from others. These men also seem to have reached a level of contentment, not needing products or material possessions to achieve fulfillment, status, or a particular masculine identity. These men have practical and durable tastes that reflect low cultural capital (LCC) consumption but have the means and education in many instances to engage in high cultural capital (HCC) consumption. The men in this study adamantly proclaim that they do not define themselves by what they own nor do they appear to define themselves primarily by what they do, at least in terms of occupation. In short, these men appear complex in many ways yet live simple lives, or what might be termed complex simplicity. Copyright © 2013 John Wiley & Sons, Ltd.
Design and evaluation of a system to support collaborative search
Authors: Capra Robert , Chen Annie T. , Hawthorne Katie , Arguello Jaime , Shaw Lee , Marchionini Gary 
Published: January 2013

AbstractWe describe a collaborative search system called Results Space to support small groups of users in conducting asynchronous collaborative searches. We discuss the design of the system and present results from a laboratory evaluation. We also describe the development of an asynchronous collaborative task scenario (based on a task from the TREC Robust test collection) designed to elicit naturalistic behaviors with the system. Our results show that participants used the collaborative features not just to avoid duplication of effort, but also to check and refine collaborators' work, to gain a general understanding of collaborator's actions, and to get ideas for new queries. Although we expected participants to use the collaborative awareness mechanisms to find and rate new items, we found that participants were more likely to make ratings for result items that had been previously rated by their collaborators. Considered together, these results suggest a range of tactics and behaviors that collaborative search tools should support.
How can tutors engage property students in controlled teaching environments?
Authors: Carter Amanda J. , Yam Sharon 
Published: January 2013

PurposeThe purpose of this paper is to investigate the role and contribution of tutors to property education. Using the theory of tutor performance which outlines six behaviours which may positively influence student outcomes, this paper considers how tutors can maximise student learning and engagement in tutorials.Design/methodology/approachThis research used a mixed methods approach including student evaluations of teaching (SETs), a survey of students and reflexive journals of a tutor in property education.FindingsThis research found that conscious adoption of the behaviours recommended under the theory of tutor performance and informed by further education in the form of a Graduate Certificate in Higher Education resulted in significant improvement of SET results. Student survey responses showed the influence of “real life” experience, amongst other things, in underpinning their learning.Research limitations/implicationsWhile this research has limitations, in terms of number of responses and restriction to a single tutor, the findings indicate that tutors may have a significant influence on the engagement of students in property education. The use of the tutor's own professional experience and the use of real life scenarios within the delivery of course content may serve to ensure graduates have a greater capacity to meet employers’ expectations.Originality/valueThis research brings originality to the subject of property education by exploring issues in property education from the most fundamental level, that of the tutor. This level of analysis is enhanced by the newness of the tutor in question to academia which highlights property education with new eyes, unencumbered with years of routine teaching experience. The incorporation of reflexive methods with a survey and SETs provides rich experience‐filled data that considers the process of property education and the ways in which purposeful skills enrichment of the tutor and the student may achieve greater outcomes for the property profession and industry.
Birth order progressively affects childhood height
Authors: Savage Tim , Derraik José G. B. , Miles Harriet L. , Mouat Fran , Cutfield Wayne S. , Hofman Paul L. 
Published: January 2013

SummaryBackgroundThere is evidence suggesting that first‐born children and adults are anthropometrically different to later‐borns. Thus, we aimed to assess whether birth order was associated with changes in growth and metabolism in childhood.MethodsWe studied 312 healthy prepubertal children: 157 first‐borns and 155 later‐borns. Children were aged 3–10 years, born 37–41 weeks gestation, and of birth weight appropriate‐for‐gestational‐age. Clinical assessments included measurement of children's height, weight, fasting lipid and hormonal profiles and DEXA‐derived body composition.ResultsFirst‐borns were taller than later‐borns (P < 0·0001), even when adjusted for parents’ heights (0·31 vs 0·03 SDS; P = 0·001). There was an incremental height decrease with increasing birth order, so that first‐borns were taller than second‐borns (P < 0·001), who were in turn taller than third‐borns (P = 0·007). Further, among sibling pairs both height SDS (P = 0·009) and adjusted height SDS (P < 0·0001) were lower in second‐ vs first‐born children. Consistent with differences in stature, first‐ (P = 0·043) and second‐borns (P = 0·003) had higher IGF‐I concentrations than third‐borns. Both first‐ (P < 0·001) and second‐borns (P = 0·004) also had reduced abdominal adiposity (lower android fat to gynoid fat ratio) when compared with third‐borns. Other parameters of adiposity and blood lipids were unaffected by birth order.ConclusionsFirst‐borns were taller than later‐born children, with an incremental height reduction from first to third birth order. These differences were present after correction for genetic height, and associated to some extent with alterations in plasma IGF‐I. Our findings strengthen the evidence that birth order is associated with phenotypic changes in childhood.
Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells
Authors: Sanders Deborah A , Ross-Innes Caryn S , Beraldi Dario , Carroll Jason S , Balasubramanian Shankar 
Published: January 2013

Abstract
Background
The forkhead transcription factor FOXM1 is a key regulator of the cell cycle. It is frequently over-expressed in cancer and is emerging as an important therapeutic target. In breast cancer FOXM1 expression is linked with estrogen receptor (ERα) activity and resistance to endocrine therapies, with high levels correlated with poor prognosis. However, the precise role of FOXM1 in ER positive breast cancer is not yet fully understood.

Results
The study utilizes chromatin immunoprecipitation followed by high-throughput sequencing to map FOXM1 binding in both ERα-positive and -negative breast cancer cell lines. The comparison between binding site distributions in the two cell lines uncovered a previously undescribed relationship between binding of FOXM1 and ERα. Further molecular analyses demonstrated that these two factors can bind simultaneously at genomic sites and furthermore that FOXM1 regulates the transcriptional activity of ERα via interaction with the coactivator CARM1. Inhibition of FOXM1 activity using the natural product thiostrepton revealed down-regulation of a set of FOXM1-regulated genes that are correlated with patient outcome in clinical breast cancer samples.

Conclusions
These findings reveal a novel role for FOXM1 in ERα transcriptional activity in breast cancer and uncover a FOXM1-regulated gene signature associated with ER-positive breast cancer patient prognosis.
Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
Authors: Seward Matthew E. , Swanson Eric , Norambuena Andrés , Reimann Anja , Cochran J. Nicholas , Li Rong , Roberson Erik D. , Bloom George S. 
Published: January 2013

SummaryNormally post-mitotic neurons that aberrantly re-enter the cell cycle without dividing account for a substantial fraction of the neurons that die in Alzheimer's disease (AD). We now report that this ectopic cell cycle re-entry (CCR) requires soluble amyloid-β (Aβ) and tau, the respective building blocks of the insoluble plaques and tangles that accumulate in AD brain. Exposure of cultured wild type (WT) neurons to Aβ oligomers caused CCR and activation of the non-receptor tyrosine kinase, fyn, the cAMP-regulated protein kinase A and calcium-calmodulin kinase II, which respectively phosphorylated tau on Y18, S409 and S416. In tau knockout (KO) neurons, Aβ oligomers activated all three kinases, but failed to induce CCR. Expression of WT, but not Y18F, S409A or S416A tau restored CCR in tau KO neurons. Tau-dependent CCR was also observed in vivo in an AD mouse model. CCR, a seminal step in AD pathogenesis, therefore requires signaling from Aβ through tau independently of their incorporation into plaques and tangles.
Crystal structure of catena-poly[[diaqua(benzoate-κO1)cobalt(II)]-μ-4,4'- bis-(1,2,4-triazol-1-ylmethyl)biphenyl-κ2-N:N'], [Co(C18H16N6)(C7H5O2)2(H2O)2]n, C32H30CoN6O6
Authors: Song Lianqing , Lin Lin , Zhao Meihong , Cui Guoshi , Gao Jianghua 
Published: January 2013

Abstract C32H30CoN6O6, monoclinic, P21/c (no. 14), a = 16.452(3) Å, b = 5.495(1) Å, c = 17.295(4) Å, β = 113.39(3)°, V = 1435.0 Å3, Z = 2, Rgt(F) = 0.0482, wRref(F2) = 0.1203, T = 293 K.
Crystal structure of 1-benzyl-3-cyclododecyloxymethylimidazolium tetrafluoroborate, [C23H35N2O][BF4], C23H35BF4N2O
Authors: Chmielewska Sylwia , Skrzypczak A. , Królikowska M. 
Published: January 2013

Abstract C23H35BF4N2O, triclinic, P1̄ (no. 2), a = 7.8372(6) Å, b = 9.5216(6) Å, c = 16.0650(9) Å, α = 96.431(5)°, β = 90.017(5)°, γ = 100.086(6)°, V = 1172.6 Å3, Z = 2, Rgt(F) = 0.0411, wRref(F2) = 0.0979, T = 100 K.
Decline in incidence of HIV and hepatitis C virus infection among injecting drug users in Amsterdam; evidence for harm reduction?
Authors: de Vos Anneke S. , van der Helm Jannie J. , Matser Amy , Prins Maria , Kretzschmar Mirjam E. E. 
Published: January 2013

AbstractAimsIn Amsterdam, HIV prevalence has nearly halved among injecting drug users (IDU) since 1990. Hepatitis C virus (HCV) prevalence also declined; HIV and HCV incidence dropped to nearly zero. We examined possible explanations for these time trends, among which the implementation of harm reduction measures aimed at reducing the risk behaviour of IDU.DesignWe used individual‐based modelling of the spread of HIV and HCV. Information about demographic parameters was obtained from the Amsterdam Cohort Study (ACS) among drug users. The model included changes in inflow of new IDU and death rates over time, the latter dependent on age and time since HIV seroconversion. We considered different scenarios of risk behaviour.SettingIDU in Amsterdam.MeasurementsSimulated HIV and HCV incidence and prevalence were compared with ACS data.FindingsAssuming that harm reduction measures had led to a strong decrease in risk behaviour over time improved the model fit (squared residuals decreased by 30%). However, substantial incidence and HIV prevalence decline were already reproduced by incorporating demographic changes into the model. In particular, lowered disease spread might be a result of depletion of high‐risk IDU among those at risk for disease, and a decrease in the number of high‐risk individuals in the population due to HIV‐related mortality.ConclusionsMarked decreases in HIV and HCV in Amsterdam since 1990 could be due partly to harm reduction measures; however, they may also be attributable largely to changes in the IDU population. Future research aimed at quantifying the benefits of interventions should not neglect the impact of natural epidemic progression and demographic changes.
Subtyping first‐episode non‐affective psychosis using four early‐course features: potentially useful prognostic information at initial presentation
Authors: Compton Michael T. , Kelley Mary E. , Ionescu Dawn F. 
Published: January 2013

AbstractAimHeterogeneity of symptoms, course and outcomes in primary psychotic disorders complicates prognosis, treatment and diverse aspects of research. This study aimed to identify interpretable subtypes of first‐episode non‐affective psychosis based on four early‐course features (premorbid academic functioning, premorbid social functioning, duration of the prodrome and age at onset of psychosis).MethodsData from 200 well‐characterized patients hospitalized in public‐sector inpatient units for first‐episode non‐affective psychosis were used in latent profile analyses. Derived subtypes were then compared along a number of clinical dimensions using analyses of variance.ResultsUsing four early‐course features, three classes were derived. A good premorbid/short prodrome subtype was characterized by a lower severity of positive symptoms, better social/occupational/global functioning, and a shorter duration of untreated psychosis; a poor premorbid/early onset subtype demonstrated greater negative and preoccupation symptoms, as well as greater psychosocial problems; and a long prodrome/late onset subtype was characterized by greater dysphoric symptoms.ConclusionsFindings indicate a need for further research with first‐episode samples on the utility of subtyping based on early‐course (premorbid, prodromal and onset‐related) characteristics. Such efforts could enhance the parsing of heterogeneity, thereby advancing clinical practice and research.
Establishment of an unrelated umbilical cord blood bank qualification program: ensuring quality while meeting Food and Drug Administration vendor qualification requirements
Authors: Rabe Fran , Kadidlo Diane , Van Orsow Lisa , McKenna David 
Published: January 2013

BackgroundQualification of a cord blood bank (CBB) is a complex process that includes evaluation of multiple aspects of donor screening and testing, processing, accreditation and approval by professional cell therapy groups, and results of received cord blood units. The University of Minnesota Medical Center Cell Therapy Laboratory has established a CBB vendor qualification process to ensure the CBB meets established regulatory and quality requirements.Study Design and MethodsThe deployed qualification of CBBs is based on retrospective and prospective review of the CBB.ResultsForty‐one CBBs were evaluated retrospectively: seven CBBs were disqualified based on failed quality control (QC) results. Eight CBBs did not meet the criteria for retrospective qualification because fewer than 3 cord blood units were received and the CBB was not accredited. As of March 2012, three US and one non‐US CBBs have been qualified prospectively. One CBB withdrew from the qualification process after successful completion of the comprehensive survey and subsequent failure of the provided QC unit to pass the minimum criteria. One CBB failed the prospective qualification process based on processing methods that were revealed during the paper portion of the evaluation.ConclusionsA CBB qualification process is necessary for a transplant center to manage the qualification of the large number of CBBs needed to support a umbilical cord blood transplantation program. A transplant center that has utilized cord blood for a number of years before implementation of a qualification process should use a retrospective qualification process along with a prospective process.
Export‐Platform Foreign Direct Investment: Theory and Evidence
Authors: Ito Tadashi 
Published: January 2013

AbstractThis paper proposes a model that accounts for ‘export‐platform’ FDI – a form of FDI that is common in the data but rarely discussed in the theoretical literature. Unlike the previous literature, this paper’s theory nests all the typical modes of supply, including exports, horizontal and vertical FDI, horizontal and vertical export‐platform FDI. The theory yields the testable hypothesis that a decrease in either inter‐regional or intra‐regional trade costs induces firms to choose export‐platform FDI. The empirical analysis provides descriptive statistics that point to large proportions of third country exports of US FDI, and an econometric analysis, whose results are in line with the model’s predictions. The paper suggests policy implications for nations seeking to attract FDI.