bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opioid Overdose After Medication for Opioid Use Disorder Initiation Following Hospitalization or ED Visit
Authors: Weiner Scott G. , Little Kacey , Yoo Jiah , Flores Diana P. , Hildebran Christi , Wright Dagan A. , Ritter Grant A. , El Ibrahimi Sanae 
Published: July 2024

ImportanceHospitalizations related to opioid use disorder (OUD) represent an opportunity to initiate medication for OUD (MOUD).ObjectiveTo assess whether starting MOUD after a hospitalization or emergency department (ED) visit is associated with the odds of fatal and nonfatal opioid overdose at 6 and 12 months.Design, Setting, and ParticipantsThis population-based cohort study used data from the Oregon Comprehensive Opioid Risk Registry, which links all payer claims data to other administrative health datasets, for individuals aged 18 years or older who had diagnosis codes related to OUD recorded at an index ED visit or hospitalization from January 2017 to December 2019. Data were analyzed between May 2023 and January 2024.ExposuresReceipt of MOUD within the 7 days after an OUD-related hospital visit.Main Outcomes and MeasuresThe primary outcome was fatal or nonfatal overdose at 6 and 12 months after discharge. Sample characteristics, including age, sex, insurance plan, number of comorbidities, and opioid-related overdose events, were stratified by receipt or nonreceipt of MOUD within 7 days after an OUD-related hospital visit. A logistic regression model was used to investigate the association between receipt of MOUD and having an opioid overdose event.ResultsThe study included 22 235 patients (53.1% female; 25.0% aged 25-39 years) who had an OUD-related hospital visit during the study period. Overall, 1184 patients (5.3%) received MOUD within 7 days of their ED visit or hospitalization. Of these patients, 683 (57.7%) received buprenorphine, 463 (39.1%) received methadone, and 46 (3.9%) received long-acting injectable naltrexone. Patients who received MOUD within 7 days after discharge had lower adjusted odds of fatal or nonfatal overdose at 6 months compared with those who did not (adjusted odds ratio [AOR], 0.63; 95% CI, 0.41-0.97). At 12 months, there was no difference in adjusted odds of fatal or nonfatal overdose between these groups (AOR, 0.79; 95% CI, 0.58-1.08). Patients had a lower risk of fatal or nonfatal overdose at 6 months associated with buprenorphine use (AOR, 0.50; 95% CI, 0.27-0.95) but not with methadone use (AOR, 0.57; 95% CI, 0.28-1.17).Conclusions and RelevanceIn this cohort study of individuals with an OUD-related hospital visit, initiation of MOUD was associated with reduced odds of opioid-related overdose at 6 months. Hospitals should consider implementing programs and protocols to offer initiation of MOUD to patients with OUD who present for care.
Misdiagnosis, Missed Diagnosis, and Delayed Diagnosis of Lupus: A Qualitative Study of Rheumatologists
Authors: Bane Shalmali , Falasinnu Titilola , Espinosa Patricia Rodriguez , Simard Julia F. 
Published: July 2024

ObjectiveDiagnostic errors in outpatient settings lead to significant consequences, especially in rare diseases such as systemic lupus erythematosus (SLE). A recent vignette‐based experimental study revealed that demographic factors influenced rheumatologists’ diagnoses of SLE, raising concerns about potential diagnostic biases. We conducted a qualitative study to contextualize these results to generate insights about diagnostic challenges and biases, and root causes.MethodsWe conducted 41 semistructured interviews among US rheumatologists. Transcripts were independently coded by at least two coders using a hybrid deductive–inductive approach and thematic analysis. A team of four researchers reviewed and defined themes collectively, and also resolved any discrepancies.ResultsParticipants were 66% women, and 49% had more than10 years of postfellowship experience. Five major themes were generated, including receiving training through the lens of race or sex, the role of the documented epidemiology of SLE, pattern recognition and test‐taking strategies, patient vignettes as an imperfect proxy for patient interactions, and varied consequences to patients from diagnostic bias. Participants noted that the consequences of diagnostic bias could include progressed disease from delayed diagnosis, unnecessary and inappropriate treatment due to missed diagnosis or misdiagnosis, and increased cost and harm.ConclusionThis study underscores the unique challenges of diagnosing SLE, with complex factors contributing to diagnosis bias and delays. Interventions during medical education could prevent downstream diagnostic biases. Future research should explore interventions to mitigate diagnostic bias and refine vignettes to better mirror real‐world clinical scenarios. Understanding diagnostic bias in SLE is crucial for improving patient outcomes and refining medical training practices.image
Scalable Fabrication of Large‐Scale, 3D, and Stretchable Circuits
Authors: Guo Dengji , Pan Taisong , Li Fan , Wang Wei , Jia Xiang , Hu Taiqi , Wang Zhijian , Gao Min , Yao Guang , Huang Zhenlong , Peng Zujun , Lin Yuan 
Published: July 2024

AbstractStretchable electronics have demonstrated excellent potential in wearable healthcare and conformal integration. Achieving the scalable fabrication of stretchable devices with high functional density is the cornerstone to enable the practical applications of stretchable electronics. Here, a comprehensive methodology for realizing large‐scale, 3D, and stretchable circuits (3D‐LSC) is reported. The soft copper‐clad laminate (S‐CCL) based on the “cast and cure” process facilitates patterning the planar interconnects with the scale beyond 1 m. With the ability to form through, buried and blind VIAs in the multilayer stack of S‐CCLs, high functional density can be achieved by further creating vertical interconnects in stacked S‐CCLs. The application of temporary bonding substrate effectively minimizes the misalignments caused by residual strain and thermal strain. 3D‐LSC enables the batch production of stretchable skin patches based on five‐layer stretchable circuits, which can serve as a miniaturized system for physiological signals monitoring with wireless power delivery. The fabrications of conformal antenna and stretchable light‐emitting diode display further illustrate the potential of 3D‐LSC in realizing large‐scale stretchable devices.
Inkjet Printing of Magnetically Responsive Photonic Crystals
Authors: Smirnov Artyom , Pogosian Tamara , Povarov Svyatoslav , Gunina Ekaterina , Milichko Valentin , Morozov Maxim , Vinogradov Alexandr 
Published: July 2024

AbstractMagnetic colloidal nanocrystalline clusters (MCNCs) exhibit a color‐changing response to a magnetic field due to their tunable assembly into photonic crystals demonstrating visible light diffraction. The use of this response to obtain a magnetically sensitive color micropattern on the surface of a solid substrate requires appropriate scalable technologies for deposition of MCNCs. Here, inkjet printing of MCNCs onto the surface of a solid substrate coated with uncured polydimethylsiloxane is addressed and demonstrate their capability to form desired patterns with structural colors from blue to red controlled by external magnetic field. The results, thereby, pave the way to semi‐commercial manufacture an anticounterfeiting imaging at a large scale.
Active Control of Temperature‐Sensitive GaN‐Graphene van der Waals Heterojunctions Integrated Metasurfaces: A Platform for Multifunctional Micro–Nanophotonic Devices
Authors: Wu G. F. , Yan F. P. , Liang L. J. , Wang W. , Li T. , Li Z. H. , Yan X. , Zhang R. , Yao H. Y. , Wang Z. Q. , Hu X. F. , Wang L 
Published: July 2024

AbstractVan der Waals (vdW) heterojunctions composed of GaN/graphene have high transmittance and excellent carrier transport properties. The combination of multidimensional hybrid heterojunctions with metasurfaces can open up many fascinating prospects for novel optical components over a broad range of the electromagnetic spectrum. This work experimentally demonstrates a multifunctional temperature‐sensitive meta‐device based on GaN/graphene vdW heterojunctions integrated with a metasurface. Notably, it is discovered that the conductivity of the vdW heterojunctions increases rapidly when it is excited by a thermal signal, resulting in a significant change in the relative phase retardation as well as amplitude modulation of an incident THz wave. Then a continuous wavelet transform is used instead of the traditional Fourier transform, and the two‐dimensional wavelet coefficient card is built to achieve fast detection over a wider range of temperature. Simultaneously, the variation of temperature dynamically controls the contributions of the multipoles, eventually determining the active switching of exotic anapoles with extreme non‐radiative confinement to highly radiative electric dipoles. This work offers the possibility of designing novel chip‐scale multifunctional thermal tuning devices and promotes the potential application of active micro‐nanophotonic devices in temperature sensors, terahertz modulators, and dynamic near‐field imaging.
IL‐33 Facilitates Fibro‐Adipogenic Progenitors to Establish the Pro‐Regenerative Niche after Muscle Injury
Authors: Zhang Congcong , Li Guoqi , Zhang Fan , Zhang Yanhong , Hong Shiyao , Gao Shijuan , Liu Yan , Du Jie , Li Yulin 
Published: July 2024

AbstractDuring the process of muscle regeneration post‐injury in adults, muscle stem cells (MuSCs) function is facilitated by neighboring cells within the pro‐regenerative niche. However, the precise mechanism triggering the initiation of signaling in the pro‐regenerative niche remains unknown. Using single‐cell RNA sequencing, 14 different muscle cells are comprehensively mapped during the initial stage following injury. Among these, macrophages and fibro‐adipogenic progenitor cells (FAPs) exhibit the most pronounced intercellular communication with other cells. In the FAP subclusters, the study identifies an activated FAP phenotype that secretes chemokines, such as CXCL1, CXCL5, CCL2, and CCL7, to recruit macrophages after injury. Il1rl1, encoding the protein of the interleukin‐33 (IL‐33) receptor, is identified as a highly expressed signature surface marker of the FAP phenotype. Following muscle injury, autocrine IL‐33, an alarmin, has been observed to activate quiescent FAPs toward this inflammatory phenotype through the IL1RL1‐MAPK/NF‐κB signaling pathway. Il1rl1 deficiency results in decreased chemokine expression and recruitment of macrophages, accompanied by impaired muscle regeneration. These findings elucidate a novel mechanism involving the IL‐33/IL1RL1 signaling pathway in promoting the activation of FAPs and facilitating muscle regeneration, which can aid the development of therapeutic strategies for muscle‐related disorders and injuries.
High Defect Tolerance in Heavy‐Band Thermoelectrics
Authors: Lou Qianhui , Gao Ziheng , Han Shen , Liu Feng , Fu Chenguang , Zhu Tiejun 
Published: July 2024

AbstractThe insensitivity of thermoelectric (TE) performance to defects and impurities induced by off‐stoichiometry or low‐purity raw elements is crucial for the low‐cost mass production of highly efficient TE materials. Here it is demonstrated that heavy‐band TE materials with high optimized carrier concentration can exhibit a high tolerance against the off‐stoichiometry in their composition. Using the heavy‐band half‐Heusler compounds as examples, it is found that for ZrNiSn with optimal carrier concentration, the off‐stoichiometry of the nominal composition in between ±5% only results in a fluctuation of its peak zT value less than 10%. A composition‐zT phase diagram is thus established, guiding the exploration of a wide nominal composition region with peak zT values exceeding 1.0. The high defect tolerance observed in heavy‐band TE materials enables the achievement of high TE performance using low‐purity raw elements. As demonstrated in several systems, including n‐type ZrNi(Sn, Sb), (Zr, Nb)CoSb, and p‐type ZrCo(Sb, Sn), comparable zT values are attained when utilizing low‐purity raw elements (≈99.5%), instead of the high‐purity ones (99.95–99.999%), leading to substantial cost saving. These findings highlight the importance of understanding defect tolerance in TE materials, which could offer an additional advantage for their practical applications.
Fluorescence‐activated screening of polyester‐depolymerizing enzymes based on pseudo‐PET polythioester plastics
Authors: Wang Yuanbo , Zhou Jie , Qiu Canhao , Wang Lei , Zheng Shiyue , Peng Junqian , Lu Sheng , Wang Fang , Yu Ziyi , Dong Weiliang , Jiang Min , Chen Xiaoqiang 
Published: July 2024

AbstractWhile fluorescence‐based high‐throughput screening (HTS) has been valuable for identifying enzymes and microorganisms for polyethylene terephthalate (PET) depolymerization, the traditional approach relies on cleaving ester bonds in small‐molecule probes, limiting its ability to directly detect activity towards polymeric PET substrates. This study proposes a novel fluorescence‐based screening strategy for detecting the release of sulfhydryl groups during the depolymerization of pseudo‐PET polythioesters by polyester hydrolases. The strategy successfully identifies the polyester‐depolymerizing activity of leaf‐branch compost cutinase (LCCICCG), whereas porcine liver esterase (PLE) only hydrolyses small molecular substrates. Furthermore, the strategy can be integrated with a droplet microfluidic system for high‐throughput screening of LCCICCG. This work further demonstrates the applicability of the microplate reader platform for screening polyester‐depolymerizing bacteria. This novel fluorescence‐based approach offers an efficient strategy to identify enzymes and microbial resources for depolymerizing polyester‐like plastics.
Mussel‐inspired stretchable, anti‐fatigue, self‐healing and biocompatible hydrogel adhesives
Authors: Zhang Kaiyi , Yang Sheng'ao , Liu Yinghua , Teng Hao , Zhang Yifan , Luo Faliang 
Published: July 2024

AbstractHydrogels can form physically or chemically interactions with tissues and are widely used in the design of bioadhesive material. Polydopamine (PDA)/polyacrylamide (PAM)‐based adhesion hydrogels have emerged as one of the hydrogel adhesive materials with great potential for development. However, this type of hydrogel has low mechanical and adhesion properties, which has certain limitations in practical applications. Herein, inspired by the mussel adhesion mechanism, we introduced PDA into PAM/3‐aminophenylboronic acid grafted sodium alginate (SA‐PBA) double network system prepared a series of adhesive hydrogels, PDA was crosslinked by dynamic boronic ester bonds with SA‐PBA. The experimental results established that the hydrogels have favorable adhesive, anti‐fatigue, stretchable, and self‐healing properties. Cytocompatibility assay and in vitro hemolysis assay also indicated that the multifunctional hydrogel has excellent cytocompatibility and hemocompatibility.
Interplay of Size and Magnetic Effects in Electrocatalytic Water Oxidation Activity of Sub‐10 nm NiOx Supported Porous Hard‐Carbons
Authors: Yadav Subham , Baghel Niranjan S. , Sarkar Shaibal K. , Subramaniam Chandramouli 
Published: July 2024

AbstractThis report describes a systematic approach for precise engineering of a catalyst‐metal oxide interface through combining complementary approaches of chemical vapor deposition and atomic layer deposition. Specifically, Chemical Vapor Deposition (CVD) fabricated nanostructured hard‐carbon framework (NCF) is employed as synergistic support for precise deposition of NiOx particles through Atomic Layer Deposition (ALD). The three variants of NCF‐NiOx system (dimensions ranging from 3–12 nm, surface coverage ranging from 0.14 %–2 %) achieved exhibit unique electrocatalytic water oxidation activities, that are further strongly influenced by an external magnetic field (Hext). This confluence of size engineering and associated magnetic field effects interplay to produce the largest lowering in Rct at Hext=200 mT. A comprehensive analysis of electrocatalytic parameters including the Tafel slope and double layer capacitance establishes further insights on co‐relation of size effect and magnetic properties to understand the role of nanocarbon supported transition metal oxides in water electrolysis.
Cold Moves: Cryogenics in Indo‐German Research Networks**
Authors: Wittje Roland 
Published: July 2024

AbstractBy unravelling the complexities and dynamics of a collaboration between scientists in India and West Germany to establish a cryogenic network, this paper intends to contribute to our understanding of the transnational movement of research technologies during the Cold War. In 1971, a cryogenic laboratory including a helium and a nitrogen liquefier was set up at the physics department of the Indian Institute of Technology (IIT) Madras as part of the Indo‐German partnership at IIT Madras between 1959 and 1974. As a generic research technology with many applications, cryogenics became crucial for a solid state research agenda for semiconductor development. After initial difficulties, Ramaswami Srinivasan at IIT Madras and Gustav Klipping of the Fritz Haber Institute in Berlin built a successful collaboration based on mutual trust and on Indian and German scientists travelling and working in each other's laboratories. If the initial motivation of the Indo‐German partnership was informed by the logic of Cold War development policy, Klipping and Srinivasan developed their collaboration into a vibrant cryogenic research network around different actors, instruments, and skills moving between India and the Federal Republic of Germany.
Analysis of the efficacy and adverse effects of nusinersen in the treatment of children with spinal muscular atrophy in China
Authors: Li Dan , Yang Jie , Wang Xueying , Yang Lin , Luo Rong , Huang Shaoping 
Published: July 2024

AbstractObjectiveThis study was based on a retrospective clinical observational cohort study of a two‐center application of nusinersen in China to evaluate the clinical efficacy and adverse effects of nusinersen in the treatment of SMA (spinal muscular atrophy) Types 1–3.MethodsClinical data from children with clinically and genetically confirmed 5qSMA from a double center in western China (the Second Affiliated Hospital of Xi'an Jiaotong University and the Second Hospital of West China of Sichuan University). All children were younger than 18 years of age. Patients were assessed for motor function and underwent blood and fluid tests before each nusinersen injection.ResultsAt 14‐month follow‐up, 100% of children had improved their HFMSE (Hammersmith Functional Motor Scale Expanded) score, 83.6% had improved their CHOP INTEND (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders) score, and 66.6% had improved their RULM (Revised Upper Limb Module) score by ≥3 points from baseline, and their 6MWT (6‐min walk test) was 216.00 ± 52.08 m longer than at baseline. The age of the child at the start of treatment was negatively correlated with the clinical efficacy of nusinersen; the younger the child, the better the response to treatment. No significant adverse effects affecting the treatment and quality of life of the child were observed during the treatment of SMA with nusinersen.ConclusionThis study concluded that nusinersen is clinically beneficial for children with SMA in western China, with mild adverse effects.
Synthesis, Characterization, DNA binding, Biological Significance, and Molecular Docking Approaches of a Palladium(II) Complex with Ciprofloxacin for More Efficient Therapy
Authors: Seddik Ramy G. , Rashidi Fatma B. , Salah‐Eldin Doaa S. , Shoukry Azza A. 
Published: July 2024

AbstractTo evaluate the biotransformation and the mechanism of binding as well as the biological impact of metal‐based‐ drugs involving Pd(II), known to have high potency and low toxicity for use as anticancer therapeutics, in the present study, a newly synthesized palladium (II) complex, [Pd(CPF)(OH2)2]2+ (where CPF is ciprofloxacin), has been synthesized and characterized and thoroughly evaluated for its antimicrobial properties. The interaction of the diaqua complex with CT‐DNA and BSA was studied through various techniques, including UV‐vis spectroscopy, thermal denaturation, viscometry, gel electrophoresis, ethanol precipitation, and molecular docking studies. The results indicate that the complex exhibits a robust binding interaction with CT‐DNA, possibly via minor groove binding and (or) electrostatic interactions. Furthermore, the complex displays good binding affinity towards BSA, indicating its potential as a target for DNA and BSA in biological media. The invitro cytotoxicity assay reveals that this complex can be classified as a promising cell growth inhibitor against MCF‐7, HT‐29, and A549. Thus, this newly synthesized palladium (II) complex is a promising candidate for further exploration as a potential anticancer therapeutic.
Three New Polyprenylated Benzophenone Derivatives Isolated from Clusia burle‐marxii
Authors: do Carmo C. Silva Maria , Carvalho Fernanda V. , Ferreira Antonio G. , Venâncio Tiago , da Silva Maria Fátima G. F. , Silva Victor Diogenes A. , Costa Silvia L. , Ferraz Caline G. , Ribeiro Paulo R. 
Published: July 2024

AbstractThree new polyprenylated benzophenone derivatives named burlemarxiones G−I (1‐3) were isolated from C. burle‐marxii trunks (compound 1) and leaves (compounds 2 and 3), along with the known compound burlemarxione F. Burlemarxione G (1) was isolated after methylation with diazomethane and it is the keto‐enol tautomeric pair of burlemarxione F. Burlemarxione H (2) derives from burlemarxiones F and G, but it has additional rings due to cyclization of the prenyl group attached to C‐5 that establishes new single bonds between C‐1 and C‐23, as well as, between C‐24 and C‐29. Burlemarxione I (3) has two additional cyclizations: the first encompasses the cyclization of the former isopentenyl group into an 11,11‐dimethyl‐six‐membered ring, whereas the second produces additional rings due to the cyclization of the prenyl group attached to C‐5 that establishes new single bonds between C‐1 and C‐23, as well as, between C‐24 and C‐29. All three compounds showed moderate anti‐glioma activity. These results show that C. burle‐marxii is an important source of sophisticated polyprenylated benzophenone derivatives.
Photocatalytic Synthesis and Functionalization of Sulfones, Sulfonamides and Sulfoximines
Authors: Garrido‐González José J. , Medrano‐Uribe Katy , Rosso Cristian , Humbrías‐Martín Jorge , Dell'Amico Luca 
Published: July 2024

AbstractSulfur(VI)‐based functional groups are popular scaffolds in a wide variety of research fields including synthetic and medicinal chemistry, as well as chemical biology. The growing interest in sulfur(VI)‐containing molecules has motivated the scientific community to explore new methods to synthesize and modify them. Here, photocatalysis plays a key role granting access to new types of reactivity under mild reaction conditions. In this Perspective, we present a selection of works reported in the last six years focused on the photocatalytic assembly and reactivity of sulfones, sulfonamides, and sulfoximines. We addressed the key synthetic intermediates for each transformation, while discussing limitations and strength points of the protocols. Future directions of the field are finally presented.