bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced protein formulations
Authors: Wang Wei 
Published: April 2015

AbstractIt is well recognized that protein product development is far more challenging than that for small‐molecule drugs. The major challenges include inherent sensitivity to different types of stresses during the drug product manufacturing process, high rate of physical and chemical degradation during long‐term storage, and enhanced aggregation and/or viscosity at high protein concentrations. In the past decade, many novel formulation concepts and technologies have been or are being developed to address these product development challenges for proteins. These concepts and technologies include use of uncommon/combination of formulation stabilizers, conjugation or fusion with potential stabilizers, site‐specific mutagenesis, and preparation of nontraditional types of dosage forms—semiaqueous solutions, nonfreeze‐dried solid formulations, suspensions, and other emerging concepts. No one technology appears to be mature, ideal, and/or adequate to address all the challenges. These gaps will likely remain in the foreseeable future and need significant efforts for ultimate resolution.
What about a dimension of engagement, equity, and diversity practices? A critique of the next generation science standards
Authors: Rodriguez Alberto J. 
Published: April 2015

AbstractIn this paper, I offer a critique of A Framework for K‐12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) and of the Next Generation Science Standards (Achieve, 2013). While the new version of the science education standards and the arguments put forward to support them are an improvement from the previous version of the NRC Science Education Standards, we must pause and reflect on the implications on jumping on another education reform, fast moving train. Using sociotransformative constructivism as a guiding theoretical lens, I argued that the Conceptual Framework and NGSS documents fall short due to the lack of retrospection, the on‐going contradictory discourses, and the lack of voice and representation in the development of these important policy documents. Suggestions for improvement and discussion are offered in hope that we might prevent the NGSS from having as little impact on teachers' practice and on students' learning as the previous version of the national science education standards had. © 2015 Wiley Periodicals, Inc. J Res Sci Teach 52: 1031–1051, 2015.
“How Do You Draw Freedom?”
Authors: Leland Christine H. , Ociepka Anne , Wackerly Amy 
Published: April 2015

AbstractChildren and their teacher participated in a project that explored the question of how engaging in transmediation after hearing a story might affect children's meaning construction. In this article we share our work with a teacher and her third graders as they were challenged to move from the traditional activity of drawing a picture about a story to drawing a picture that symbolized the underlying meaning of a story.
Highlighting the effects of land‐use change on a threatened amphibian in a human‐dominated landscape
Authors: Cayuela Hugo , Lambrey Julie , Vacher Jean‐Pierre , Miaud Claude 
Published: April 2015

AbstractIn Western Europe, habitat loss and landscape fragmentation has led to significant population decline in various animal groups, including amphibians. The extinction of the last natural populations of the yellow‐bellied toad in Belgium, Luxembourg and several regions of southern and western France suggests a widespread decline. By using site‐occupancy models and adding covariates corresponding to the human‐influenced features of the landscape, we tried to identify the relative effects of different land‐use types on the species’ distribution pattern in a man‐made environment (the Alsatian Rhine floodplain in France). We recorded presence–absence data in 150 forest sample plots (300 × 300 m) and then modeled species distribution while taking into account detection errors in the field. Land‐use was recorded on two spatial scales: within the forest sample plots and in a 1500 m radius buffer area around the forest plots. In the forest plots, toad occurrence was negatively correlated with loss of forest cover to agricultural land. In contrast, occurrence is positively correlated with the density of human‐made rutted dirt paths and tracks, which provide semi‐natural breeding sites. In the 1500 m radius buffer zones around forest plots, toad occurrence was negatively correlated with the density of urbanization and road networks. These results can be used to plan conservation strategies for amphibians in human‐dominated landscapes.
Work–Family Demands and Subjective Well-being among Female Academicians: The Role of Muslim Religiosity
Authors: Achour Meguellati , Mohd Nor Mohd Roslan , Mohd Yusoff Mohd Yakub Zulkifli 
Published: April 2015

The current study examines the relationship between work–family demands and the subjective well-being of female academicians. It analyses the role of religiosity as a moderator of work–family demands and well-being. The determinants of work–family demands included in this research are workload, log working hours, irregular work schedule, number of children and their ages, and time spent on family activities. The researcher sampled 300 female academic staff employed in research universities in Kuala Lumpur, Malaysia. Their ages ranged from 30 to 60 years. The findings show that there is a negative and significant relationship of work–family demands with well-being. There is also a positive and significant relationship between religiosity and female well-being, where religiosity increases employee well-being. Thus, religiosity has a moderating effect on work–family demands and Muslim women's well-being.
Say no more! The liability of strong ties on desire for special experiences
Authors: Goode Miranda R. , Hart Kendra , Thomson Matthew 
Published: April 2015

AbstractInterpersonal connections are often involved in the planning, consuming, and reminiscing of special consumption experiences. Yet we have limited understanding of how consumers in different stages (planning versus reminiscing) influence one another and how this might vary as a function of relationship strength. From two experiments, our findings suggest that when planning a novel special experience, consumers should be cautious of others' reminiscences and, specifically, of memories shared by strong ties. In study 1, we found that a memory shared by a strong tie increases a consumer's desire to switch a novel experience. In study 2, we unpacked this effect by examining the role of savoring and internalization of memory details. When a memory was shared by a stronger (versus weaker) tie, the expected utility of savoring was reduced, and the desire to switch to a new experience increased. Post analyses suggest that this may be due to differences in the extent to which the memory is assimilated as one's own experience.
Prevention of immediate recurrence of atrial fibrillation with low‐dose landiolol after radiofrequency catheter ablation
Authors: Ishigaki Daisuke , Arimoto Takanori , Iwayama Tadateru , Hashimoto Naoaki , Kutsuzawa Daisuke , Kumagai Yu , Nishiyama Satoshi , Takahashi Hiroki , Shishido Tetsuro , Miyamoto Takuya , Watanabe Tetsu , Kubota Isao 
Published: April 2015

AbstractBackgroundImmediate recurrence of atrial fibrillation (AF) after radiofrequency (RF) catheter ablation is commonly observed within 3 d after the procedure. The mechanism and pharmacological management of immediate AF recurrence remain unclear.MethodsA total of 50 consecutive patients with paroxysmal AF were randomized to receive either low‐dose landiolol (landiolol group) or a placebo (placebo group). In the landiolol group, intravenous landiolol (0.5 μg kg−1 min−1) was administered for 3 d after AF ablation.ResultsNo serious adverse event associated with RF catheter ablation or landiolol administration was observed. The prevalence of immediate AF recurrence (≤3 d after RF catheter ablation) was significantly lower in the landiolol group than in the placebo group (16% vs. 48%, p=0.015). Although the postprocedural change in heart rate was significantly lower in the landiolol group compared to that in the placebo group, the changes in blood pressure and body temperature were not different between the two groups. Multiple logistic regression analysis revealed that landiolol treatment was the only independent predictor of immediate AF recurrence after ablation (odds ratio: 0.180; 95% confidence interval: 0.044–0.729; p=0.016).ConclusionsProphylactic administration of low‐dose landiolol after AF ablation may be effective and safe for preventing immediate AF recurrence within 3 d after AF ablation.
Where Do Injectable Stem Cell Treatments Apply in Treatment of Muscle, Tendon, and Ligament Injuries?
Authors: Mautner Kenneth , Blazuk Joseph 
Published: April 2015

AbstractTreatment options for muscle, tendon, and ligament injuries span a constantly evolving spectrum. For years, treatments focused on symptomatic relief. Closer scrutiny of symptomatic treatment suggests that the provision of transient relief of symptoms may have caused more harm than good. Cortisone injections provide a trade‐off of short‐term relief for poorer long‐term outcomes. When conventional treatment failed, patients have faced limited options including surgery, which has increased risk and limited efficacy. Regenerative injections offer a more robust option for soft tissue disease. Basic science and clinical studies show conflicting results to support the use of platelet‐rich plasma injections for soft tissue disorders, and even fewer trials have focused on injectable stem cells with limited findings. Additional studies are needed to determine the potential benefits of this regenerative therapy.
Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism
Authors: Kolahdooz Zeynab , Nasoohi Sanaz , Asle-Rousta Masoumeh , Ahmadiani Abolhassan , Dargahi Leila 
Published: April 2015

AbstractBackground: Recent evidence suggests that an extreme shift may occur in sphingosine metabolism in neuroinflammatory contexts. Sphingosine 1-phosphate (S1P)-metabolizing enzymes (SMEs) regulate the level of S1P. We recently found that FTY720, a S1P analogue, and SEW2871, a selective S1P receptor 1 (S1P1) agonist, provide protection against neural damage and memory deficit in amyloid beta (Aβ)-injected animals. This study aimed to evaluate the effects of these two analogues on the expression of SMEs as well as their anti-inflammatory roles. Methods: Rats were treated with intracerebral lipopolysaccharide (LPS) or Aβ. Memory impairment was assessed by Morris water maze and the effects of drugs on SMEs as well as inflammatory markers, TNF- α and COX-II, were determined by immunoblotting. Results: Aβ and LPS differentially altered the expression profile of SMEs. In Aβ-injected animals, FTY720 and SEW2871 treatments exerted anti-inflammatory effects and restored the expression profile of SMEs, in parallel to our previous findings. In LPS animals however, in spite of anti-inflammatory effects of the two analogues, only FTY720 restored the levels of SMEs and prevented memory deficit. Conclusion: The observed ameliorating effects of FTY720 and SEW7821 can be partly attributed to the interruption of the vicious cycle of abnormal S1P metabolism and neuro-inflammation. The close imitation of the FTY720 effects by SW2871 in Aβ-induced neuro-inflammation may highlight the attractive role of S1P1 as a potential target to restore S1P metabolism and inhibit inflammatory processes.
Are Patients with Limb and Head Tremor a Clinically Distinct Subtype of Essential Tremor?
Authors: Lenka Abhishek , Bhalsing Ketaki Swapnil , Jhunjhunwala Ketan Ramakant , Chandran Vijay , Pal Pramod Kumar 
Published: April 2015

AbstractBackground:Essential tremor (ET) is the most common tremor disorder in adults. In addition to upper limbs, the tremor in ET may also involve head, jaw, voice, tongue, and trunk. Though head tremor (HT) is commonly present in patients with ET, large comparative studies of ET patients with HT (HT+) and without HT (HT−) are few.Methods:To determine whether ET with HT is a distinct clinical subtype by comparing ET patients with and without HT, a chart review of 234 consecutive patients with ET attending the neurology clinics of the National Institute of Mental Health and Neurosciences, India, was done. A movement disorder specialist confirmed the diagnosis of ET in all patients using the National Institutes of Health collaborative genetic criteria.Results:HT was present in 44.4% of the patients. Comparison between HT+ and HT− showed that the HT+ group patients: (1) were older, (2) had later onset of tremor, (3) had unimodal distribution of age at onset with a single peak in the fifth decade, (4) had more frequent voice tremor, and (5) were more likely to have mild cervical dystonia. HT was part of presenting symptoms in nearly two thirds of the ET patients and in the rest it was detected during clinical examination.Conclusions:Several demographic and clinical variables suggest that ET patients with HT have a distinct clinical phenotype.
The Incidence of Posttraumatic Stress Disorder After Floods: A Meta-Analysis
Authors: Chen Long , Liu Aizhong 
Published: April 2015

AbstractThis study analyzes the incidence of posttraumatic stress disorder (PTSD) among flood victims, between different flood intensities, and between different time points after a flood. A search of several electronic literature databases was conducted to collect data on the incidence of PTSD after a flood. Loney criteria for research quality were used to evaluate the quality of selected search results. The combined incidence of PTSD was estimated using the Freeman-Tukey double arcsine transformation method. Subgroup analyses were conducted on different trauma intensities and different time points after a flood. Sensitivity analysis was performed to evaluate the impact of research quality. Fourteen articles were included in this meta-analysis, including a total of 40 600 flood victims; 3862 victims were diagnosed with PTSD. The combined incidence of PTSD was 15.74%. The subgroup analyses showed that the incidence of PTSD in victims who experienced severe and moderate flood intensity was higher than that in victims who experienced mild flood intensity. The incidence of PTSD was lower at 6 or more months after a flood (11.45%) than within 6 months (16.01%) of a flood. In conclusion, the incidence of PTSD among floods of different trauma intensities was statistically significant. (Disaster Med Public Health Preparedness. 2015;9:329-333)
Clinical Decision Support in the Management of Patients With Suspected Ebola Infection
Authors: Landman Adam B. , Goralnick Eric , Teich Jonathan M. 
Published: April 2015

AbstractPatients with suspected public health threats, such as Ebola, must be quickly identified and isolated on presentation to health care facilities. Patients can be screened by intake staff or other health care providers; however, perfect compliance is difficult to achieve. Well-designed, carefully placed clinical decision support (CDS) within the electronic health record can be a reliable partner in helping to rapidly identify, isolate, and care for patients with suspected Ebola infection and other emerging public health threats. We describe how different types of CDS can be applied in the clinical workflow and share how we implemented CDS to force Ebola screening upon patient presentation to our emergency department. (Disaster Med Public Health Preparedness. 2015;9:591–594)
Four Moments for Patient Hand Hygiene: A Patient-Centered, Provider-Facilitated Model to Improve Patient Hand Hygiene
Authors: Sunkesula Venkata CK , Knighton Shanina , Zabarsky Trina F. , Kundrapu Sirisha , Higgins Patricia A. , Donskey Curtis J. 
Published: April 2015

AbstractWe found that a majority of hospitalized patients were aware of the importance of hand hygiene, but observations indicated that performance of hand hygiene was uncommon. An intervention in which healthcare personnel facilitated hand hygiene at specific moments significantly increased performance of hand hygiene by patients.Infect Control Hosp Epidemiol 2015;36(8): 986–989
HISTORY, CREATIVE IMAGINATION, AND FORGIVENESS IN MEDIATION ON AN INTERNATIONAL STAGE: PRACTICAL LESSONS FROM PAUL RICOEUR'S HERMENEUTICS
Authors: Zwier Paul J. 
Published: April 2015

AbstractThis article discusses Paul Ricoeur's moral philosophy as a tool for the mediation of international disputes. It argues that Ricoeur's hermeneutics provides a lens to examine how a mediator can use language to explore with representatives of the disputing parties a deeper sense of their histories as a pathway to creative imagination and problem solving. It shows how even, and perhaps especially, religious disputants can be led into a more profound sense of the complexity of their identity and history, in order to discover the sense of urgency and responsibility that opens disputants to imaginative steps toward peace and reconciliation.In addition the article discusses Ricoeur's clear-eyed view of forgiveness as an important correction to modern-day uses of truth and reconciliation commissions. With this better understanding of the meaning and conditions of forgiveness in hand peacemakers will be able to help disputants design processes that are necessary for a lasting and just peace.Finally it briefly discusses the challenges to applying Ricoeur's hermeneutics to international conflicts.
Revisit of the Dual Bem using SVD Updating Technique
Authors: Chen J.-T. , Huang W.-S. , Fan Y. , Kao S.-K. 
Published: April 2015

AbstractThe boundary element method (BEM) is easier than the finite element method (FEM) on the viewpoint of the discretization of one dimension reduction rather than the domain discretization of finite element method. The disadvantage of BEM is the rank deficiency in the influence matrix,e.g., degenerate boundary, degenerate scale, spurious eigenvalues and fictitious frequencies, which do not occur in the FEM. The conventional BEM can not be straightforward applied to solve a problem which contains a degenerate boundary without decomposing the domain to multi-regions. A hypersingular integral equation is used to ensure a unique solution for the problem containing a degenerate boundary. By combining the singular and hypersingular equations, it’s termed the dual BEM due to its dual frame. Following the successful experience on the retrieval of information using the singular value decomposition (SVD) updating term and updating document, this technique is also used to extract out the degenerate-boundary information and the rigid-body information in the dual BEM. It is interesting to find that true information due to a rigid-body mode in physics is found in the right singular vector with respect to the corresponding zero singular value while the degenerate-boundary mode (geometry degeneracy) in mathematics is imbedded in the left singular vector with respect to the corresponding zero singular value. The role of the common right and left singular vectors of SVD for the four influence matrices in the dual BEM is also discussed in this paper. Two examples, a potential flow problem across a cutoff wall and a cracked bar under torsion were demonstrated to see the mathematical SVD structure of four influence matrices in the dual BEM.
A New Procedure for Simulating Active Lateral Force in Spatially Variable Clay Modeled by Anisotropic Random Field
Authors: Hu Y.-G. , Ching J. 
Published: April 2015

AbstractA new procedure for simulating the active lateral force (Pa) is proposed for clays with anisotropic spatially variable undrained shear strength (su). With the proposed procedure, the Pasamples can be simulated without the use of the random field finite element method (RFEM). It requires only simple algebraic calculations and chart checking. Two retaining wall examples with isotropic or anisotropic random field are used to demonstrate the effectiveness of the proposed procedure.
Stabilization of Regular Solutions for the Zakharov-Kuznetsov Equation Posed on Bounded Rectangles and on a Strip
Authors: Doronin G. G. , Larkin N. A. 
Published: April 2015

AbstractInitial–boundary-value problems for the two-dimensional Zakharov–Kuznetsov equation posed on bounded rectangles and on a strip are considered. Spectral properties of a linearized operator and critical sizes of domains are studied. An exponential decay rate of regular solutions for the original nonlinear problems is proved.
Insight into neonatal septicaemicEscherichia colifrom India with respect to phylogroups, serotypes, virulence, extended-spectrum-β-lactamases and association of ST131 clonal group
Authors: ROY S. , DATTA S. , DAS P. , GAIND R. , PAL T. , TAPADER R. , MUKHERJEE S. , BASU S. 
Published: April 2015

SUMMARYThe study characterizes a collection of 67 neonatal septicaemicEscherichia coliisolates on the basis of phylogroup, serotype, virulence, antibiotic resistance and also the association of CTX-M-producingE. coliand the ST131 clone in a developing country. Phylogroups B2 and D were predominant (33% and 19%, respectively). The most prevalent virulence factors (VFs) weretraT(69%) andiucC(68%) and most VFs were concentrated in the B2 isolates. High levels of resistance (⩾70%) to cefotaxime, ciprofloxacin and trimethoprim/sulfamethoxazole was recorded but meropenem remained the most active antimicrobial. Six (9%) of the study isolates belonged to the ST131 clone, five of which were from the same hospital, and were either indistinguishable or closely related by pulsed-field gel electrophoresis. Although the prevalence of CTX-M-15-producing isolates was high (81%), the ST131 clone was relatively infrequent (11%) in extended spectrumβ-lactamase (ESBL)-producers. The ST131 clone was characterized by the presence ofblaCTX-M-15,qnrS, aac(6′)-Ib-cr, IncF plasmids and virulence determinants such asiucC, papC, traT, usp, hlyA, iroNE.coli,cnf, andsat. We conclude that clonal spread of ST131 did not contribute directly to the high prevalence of CTX-M-15 in our settings.
Gray-Level Co-Occurrence Matrix Texture Analysis of Breast Tumor Images in Prognosis of Distant Metastasis Risk
Authors: Vujasinovic Tijana , Pribic Jelena , Kanjer Ksenija , Milosevic Nebojsa T. , Tomasevic Zorica , Milovanovic Zorka , Nikolic-Vukosavljevic Dragica , Radulovic Marko 
Published: April 2015

AbstractOwing to exceptional heterogeneity in the outcome of invasive breast cancer it is essential to develop highly accurate prognostic tools for effective therapeutic management. Based on this pressing need, we aimed to improve breast cancer prognosis by exploring the prognostic value of tumor histology image analysis. Patient group (n=78) selection was based on invasive breast cancer diagnosis without systemic treatment with a median follow-up of 147 months. Gray-level co-occurrence matrix texture analysis was performed retrospectively on primary tumor tissue section digital images stained either nonspecifically with hematoxylin and eosin or specifically with a pan-cytokeratin antibody cocktail for epithelial malignant cells. Univariate analysis revealed stronger association with metastasis risk by texture analysis when compared with clinicopathological parameters. The combination of individual clinicopathological and texture variables into composite scores resulted in further powerful enhancement of prognostic performance, with an accuracy of up to 90%, discrimination efficiency by the area under the curve [95% confidence interval (CI)] of 0.94 (0.87–0.99) and hazard ratio (95% CI) of 20.1 (7.5–109.4). Internal validation was successfully performed by bootstrap and split-sample cross-validation, suggesting that the models are generalizable. Whereas further validation is needed on an external set of patients, this preliminary study indicates the potential use of primary breast tumor histology texture as a highly accurate, simple, and cost-effective prognostic indicator of distant metastasis risk.