bluuebunny/crossref_metadata_2025_split huggingface dataset:
A good time to panic? Premorbid and postmorbid panic disorder in heart failure affects cardiac and psychiatric cause admissions
Authors: Tully Phillip J 
Published: January 2015

Objective: The authors sought to identify characteristics associated with premorbid and postmorbid panic disorder onset in relation to heart failure (HF) onset, and examine the effect on unplanned hospital admissions. Methods: In a two-stage screening process, 404 HF patients admitted to three hospitals in South Australia were referred for structured psychiatric interview when any of the following four criteria were met: (a) Patient Health Questionnaire ≥10; (b) Generalized Anxiety Disorder Questionnaire ≥ 7); (c) positive response to one-item panic attack screener; (d) or evidence of suicidality. Results: A total of 73 referred HF patients (age 60.6 ± 13.4, 47.9% female) were classified into three groups: premorbid panic disorder (27.4%), postmorbid panic disorder (24.7%), and no panic disorder (47.9%). Postmorbid panic disorder was associated with more psychiatric admissions and longer hospital stay in the 6 months prior to the index psychiatric assessment, and also in the 6 months after the index psychiatric assessment (all p <.05 unadjusted). In sensitivity analysis, years since panic disorder onset were associated with longer cardiac length of stay (β = .34, p = .03). Conclusions: Panic disorder onset in relation to HF diagnosis was associated with discrete patterns of hospital admissions for cardiac and psychiatric causes.
Should Low-Molecular-Weight Heparin be Preferred Over Unfractionated Heparin After Thrombolysis for Severity Pulmonary Embolism?
Authors: Senturk Aysegul , Ucar Elif Yilmazel , Berk Serdar , Ozlu Tevfik , Altınsoy Bulent , Dabak Gul , Cakır Ebru , Kadıoglu Esra Ekbic , Sen Hadice Selimoglu , Ozsu Savas ,   The TUPEG Study Investigators
Published: January 2015

Purpose: The role of low-molecular-weight heparin (LMWH) in managing nonmassive pulmonary embolism (PE) is well known. In unstable cases, especially after thrombolytic therapy for massive PE, unfractionated heparin (UFH) is preferred for PE management. This study aimed to investigate the effectiveness and safety of LMWH after thrombolytic therapy. Methods: A prospective, observational multicenter trial was performed in 249 patients with acute PE who required thrombolysis. Massive and submassive PEs were categorized into 2 groups depending on whether they were treated with LMWH or UFH after thrombolytic treatment. The primary end point was all-cause mortality during the first 30 days; the secondary end point included all-cause mortality, nonfatal symptomatic recurrent PEs, or nonfatal major bleeding. Results: The mean age at diagnosis was 60.7 ± 15.5 years. The PE severity was massive in 186 (74.7%) patients and submassive in 63 (25.3%). The incidence of all-cause 30-day death was 8.2% and 17.3% in patients with LMWH and UFH, respectively ( P = .031). Major hemorrhage occurred in 4% (n = 5) and 7.9% (n = 10) of patients and minor hemorrhage occurred in 9% (n = 11) and 13.4% (n = 17) of the cases treated with LMWH and UFH, respectively. Conclusion: These results suggest that LMWH treatment can be used safely in patients with PE after thrombolytic therapy.
Differential induction of plasma cells by isoforms of human TACI
Authors: Garcia-Carmona Yolanda , Cols Montserrat , Ting Adrian T. , Radigan Lin , Yuk Frank J. , Zhang Li , Cerutti Andrea , Cunningham-Rundles Charlotte 
Published: January 2015

Key PointsActivation of TACI on B cells leads to proliferation, isotype switch, and B-cell survival. Human TACI is produced in 2 isoforms; only the short form is a potent inducer of plasma-cell differentiation.
Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury
Authors: Chaaban Hala , Keshari Ravi S. , Silasi-Mansat Robert , Popescu Narcis I. , Mehta-D’Souza Padmaja , Lim Yow-Pin , Lupu Florea 
Published: January 2015

Key PointsIAIP and its anionic carbohydrate moieties bind and inhibit the damaging effects of histones both in vitro and in vivo. Cell-surface–associated negatively charged glycocalyx and matrix-associated glycosminoglycans protect against histone-induced cytotoxicity.
AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress
Authors: Sriskanthadevan Shrivani , Jeyaraju Danny V. , Chung Timothy E. , Prabha Swayam , Xu Wei , Skrtic Marko , Jhas Bozhena , Hurren Rose , Gronda Marcela , Wang Xiaoming , Jitkova Yulia , Sukhai Mahadeo A. , Lin Feng-Hsu , Maclean Neil , Laister Rob , Goard Carolyn A. , Mullen Peter J. , Xie Stephanie , Penn Linda Z. , Rogers Ian M. , Dick John E. , Minden Mark D. , Schimmer Aaron D. 
Published: January 2015

Key PointsAML cells have increased mitochondrial mass, low respiratory chain complex activities, and low spare reserve capacity compared with normal cells. AML cells have heightened sensitivity to inhibitors of the respiratory chain complexes and oxidative stressors.
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Authors: Baliakas Panagiotis , Agathangelidis Andreas , Hadzidimitriou Anastasia , Sutton Lesley-Ann , Minga Eva , Tsanousa Athina , Scarfò Lydia , Davis Zadie , Yan Xiao-Jie , Shanafelt Tait , Plevova Karla , Sandberg Yorick , Vojdeman Fie Juhl , Boudjogra Myriam , Tzenou Tatiana , Chatzouli Maria , Chu Charles C. , Veronese Silvio , Gardiner Anne , Mansouri Larry , Smedby Karin E. , Pedersen Lone Bredo , Moreno Denis , Van Lom Kirsten , Giudicelli Véronique , Francova Hana Skuhrova , Nguyen-Khac Florence , Panagiotidis Panagiotis , Juliusson Gunnar , Angelis Lefteris , Anagnostopoulos Achilles , Lefranc Marie-Paule , Facco Monica , Trentin Livio , Catherwood Mark , Montillo Marco , Geisler Christian H. , Langerak Anton W. , Pospisilova Sarka , Chiorazzi Nicholas , Oscier David , Jelinek Diane F. , Darzentas Nikos , Belessi Chrysoula , Davi Frederic , Ghia Paolo , Rosenquist Richard , Stamatopoulos Kostas 
Published: January 2015

Key Points
CLL stereotyped subset #2 (IGHV3-21/IGLV3-21) is uniformly aggressive independently of somatic hypermutation status. The prognosis for non–subset #2/IGHV3-21 CLL resembles that of the remaining CLL cases with similar somatic hypermutation status.
Tracing of paleo-shear zones by self-potential data inversion: case studies from the KTB, Rittsteig, and Grossensees graphite-bearing fault planes
Authors: Mehanee Salah A 
Published: January 2015

AbstractThis paper describes a new method for tracing paleo-shear zones of the continental crust by self-potential (SP) data inversion. The method falls within the deterministic inversion framework, and it is exclusively applicable for the interpretation of the SP anomalies measured along a profile over sheet-type structures such as conductive thin films of interconnected graphite precipitations formed on shear planes. The inverse method fits a residual SP anomaly by a single thin sheet and recovers the characteristic parameters (depth to the toph, extension in deptha, amplitude coefficientk, and amount and direction of dipθ) of the sheet. This method minimizes an objective functional in the space of the logarithmed and non-logarithmed model parameters (log(h), log(a), log(k), andθ) successively by the steepest descent (SD) and Gauss-Newton (GN) techniques in order to essentially maintain the stability and convergence of this inverse method. Prior to applying the method to real data, its accuracy, convergence, and stability are successfully verified on numerical examples with and without noise. The method is then applied to SP profiles from the German Continental Deep Drilling Program (Kontinentales Tiefbohrprogramm der Bundesrepublik Deutschla - KTB), Rittsteig, and Grossensees sites in Germany for tracing paleo-shear planes coated with graphitic deposits. The comparisons of geologic sections constructed in this paper (based on the proposed deterministic approach) against the existing published interpretations (obtained based on trial-and-error modeling) for the SP data of the KTB and Rittsteig sites have revealed that the deterministic approach suggests some new details that are of some geological significance. The findings of the proposed inverse scheme are supported by available drilling and other geophysical data. Furthermore, the real SP data of the Grossensees site have been interpreted (apparently for the first time ever) by the deterministic inverse scheme from which interpretive geologic cross sections are suggested. The computational efficiency, analysis of the numerical examples investigated, and comparisons of the real data inverted here have demonstrated that the developed deterministic approach is advantageous to the existing interpretation methods, and it is suitable for meaningful interpretation of SP data acquired elsewhere over graphitic occurrences on fault planes.
Statement of Need and Algorithm of Assessment of Competencies’ Development by Students of Different Programs
Authors: Тигина  , Tigina Mariya 
Published: January 2015

The article states the need to assess the level of formation of students’ skills as a key factor for graduates and students entering a university. An algorithm
for assessing a graduate as a future specialist in a particular professional field is offered. This algorithm will provide the most objective image of the
capabilities of a student and the knowledge he/she received in the educational process.
Essence and Aim of Interdisciplinary Competencies for Senior School Children
Authors: Шевченко  , Shevchenko Natalya 
Published: January 2015

The author retrospects tendencies of the development of interdisciplinary results treated as competencies; notes its operationability in achieving
personal goals and mutual dependencies of development processes of interdisciplinary and personal competencies. The article defines the role of
general educational activity in achieving planned academic results according to Standards of General Education, and emphasizes significance of
interdisciplinary competencies in achieving the image of a graduate in demand by new standard. Peculiarities of education of senior school children
are pointed out.
Product Market Competition and the Financing of New Ventures
Authors: de Bettignies Jean-Etienne , Duchêne Anne 
Published: January 2015

This paper examines the interaction between venture risk, product market competition, and the entrepreneur’s choice between bank financing and venture capital (VC) financing. Under bank financing, a debt-type contract emerges as optimal, which allows the entrepreneur to retain full control of the venture and thus yields strong effort incentives, as long as the entrepreneur can service the debt repayment; however, this leads to liquidation in the case of default, making the venture’s success quite sensitive to exogenous, even temporary, shocks that may hinder debt repayment. Under VC financing, an equity-type contract emerges as optimal. Although it is not sensitive to exogenous shocks, this contract requires the entrepreneur to share a fraction of the rents with the financier, thus yielding lower effort incentives for the entrepreneur. There exists a threshold level of venture risk such that bank financing is optimal if and only if venture risk is below that threshold. Product market competition increases the value of stronger entrepreneurial incentives and thus increases the maximum level of risk the entrepreneur is willing to take before switching from bank financing to VC financing. This is a robust result that is shown to hold in various models of competition, including the Hotelling, Salop, Dixit–Stiglitz, and Cournot-to-Bertrand switch. This paper was accepted by Lee Fleming, entrepreneurship and innovation.
The Hidden Cost of Accommodating Crowdfunder Privacy Preferences: A Randomized Field Experiment
Authors: Burtch Gordon , Ghose Anindya , Wattal Sunil 
Published: January 2015

Online crowdfunding has received a great deal of attention as a promising avenue to fostering entrepreneurship and innovation. Because online settings bring increased visibility and traceability of transactions, many crowdfunding platforms provide mechanisms that enable a campaign contributor to conceal his or her identity or contribution amount from peers. We study the impact of these information (privacy) control mechanisms on crowdfunder behavior. Employing a randomized experiment at one of the world’s largest online crowdfunding platforms, we find evidence of both positive (e.g., comfort) and negative (e.g., privacy priming) causal effects. We find that reducing access to information controls induces a net increase in fund-raising, yet this outcome results from two competing influences—treatment increases willingness to engage with the platform (a 4.9% increase in the probability of contribution) and simultaneously decreases the average contribution (a $5.81 decline). This decline derives from a publicity effect, wherein contributors respond to a lack of privacy by tempering extreme contributions. We unravel the causal mechanisms that drive the results and discuss the implications of our findings for the design of online platforms. This paper was accepted by Lee Fleming, entrepreneurship and innovation.
Hand hygiene is as simple as the ABCs—always, be, careful, caring and compliant
Authors: Mortell Manny 
Published: January 2015

Background: Health-care professionals (HCPs) who work in the operating room (OR) or post anaesthesia care unit (PACU) have a greater opportunity to cross-contaminate patients due to high workloads and frequent patient contact events. The prevalence of health-care-associated infections is a major health concern and patient contact in the OR and PACU can be a contributing factor, due to microbial contamination. The research published on maintaining the sterility of the OR is abundant, but less attention has been focused on patient contact by ’non-scrubbed’ HCPs in OR and PACU. Methods: An observational study was conducted on the hand hygiene compliance of ‘non-scrubbed’ HCPs working in the OR and PACU of the King Fahad Hospital, King Abdulaziz Medical City, a quaternary health-care facility in Saudi Arabia. The participants in the study were surgeons, anaesthetists, circulating and PACU nurses, with surreptitious observations being performed by two trained OR and PACU nurses. ’Sterile’ scrubbed HCPs were excluded. The observation timeframe was from January to December 2013 and the hand hygiene compliance components that were observed were the World Health Organisation ‘5 moments’ of hand hygiene ( Figure 1 ). Results: The study included 2300 opportunities (observations) for hand hygiene compliance and HCP observed 2000 nurses, 100 surgeons and 100 anaesthetists. Hand hygiene compliance in the King Abdulaziz Medical City OR and PACU was highest among nurses (> 90%) and lowest among physicians: surgeons (< 70%), followed by anaesthetists (< 50%). Conclusion: Adherence to hand hygiene guidelines by King Abdulaziz Medical City OR and PACU nurses was acceptably higher than anaesthetists and surgeons, noting that the organisational hand hygiene compliance target is 100%. However, the low compliance to hand hygiene guidelines by doctors potentially exposes patients to microbial transmission and harm and therefore validates a theory-practice-ethics gap.
Evaluating Psychological Aspects of Wood and Laminate Products in Indoor Settings with Pictures
Authors: Jiménez Paul , Dunkl Anita , Eibel Kerstin , Denk Elisabeth , Grote Vincent , Kelz Christina , Moser Maximilian 
Published: January 2015

Abstract
Natural materials in indoor settings influence the human organism positively. Wood is a natural material and shows similar positive effects on the individual's well-being. Because of similar looks and functional properties, wood can be compared with laminate. However, when investigating psychological differences, wood is usually compared with carpets, glass, leather, stone, or plastic, but not compared with a visually similar material such as laminate. The aim of this study was to analyze and compare the different psychological perception of wood and laminate products in an indoor setting. This study further investigated what specific psychological aspects can differentiate wood from laminate products, and if wood is preferred over laminate and is more likely to be purchased. Different pictures that depict wood and laminate products in an indoor setting were used to evaluate the psychological perception. This evaluation included measuring 11 quality criteria, the perception of the environmental atmosphere, and the purchase decision. The experimental design was a 2 × 2 × 2 design with repeated measures for material and sequence. The sample consisted of 93 experts as well as nonexperts for wood. The result shows that wood products are rated higher than laminate products regarding several psychological aspects, such as health, physical and mental stimulation, and performance enhancement. In addition, wood products were rated significantly more warming and cozy, and the participants would recommend, purchase, and accept more deficiencies for purchasing wood products than for laminate products. Overall, the material wood was preferred over the material laminate.
Effects of Grate Size on Grinding Productivity, Fuel Consumption, and Particle Size Distribution
Authors: Han Sang-Kyun , Han Han-Sup , Bisson Joel A. 
Published: January 2015

Abstract
Matching the right feedstock quality to a biomass conversion technology effectively facilitates the energy conversion process and improves the economic feasibility of forest biomass for energy production. In this study, we conducted a controlled experiment on a horizontal grinder to evaluate the effect of three different grate size combinations on grinding productivity, fuel consumption, and particle size distribution for two different biomass types (mixed conifer slash and hardwood whole trees). Mixed conifer slash resulted in higher grinding productivity (39.0 to 45.1 bone dry US tons/h) and a lower fuel consumption rate (0.57 to 0.90 gal/h) than hardwood whole trees. Small grate size configurations (2-, 3-, and 3-in. holes) in the grinder had low grinding productivity and higher fuel consumption rates compared with large grate size configurations (3-, 4-, and 4-in. holes). High grinding productivity and low fuel consumption rates were accomplished by using a new anvil type that is manufactured with holes in the plate. The study also showed that production of small feedstock particles (length, <2 in.) from logging slash was operationally feasible by using small grates and a newly designed anvil. Additional research is needed to further control oversized materials and improve our knowledge about the effect of moisture content on grinding productivity, especially with a wide range of grate size combinations.
An Interface to Support Independent Use of Facebook by People With Intellectual Disability
Authors: Davies Daniel K. , Stock Steven E. , King Larry R. , Brown R. Brian , Wehmeyer Michael L. , Shogren Karrie A. 
Published: January 2015

Abstract
Use of social networking sites, such as Facebook, is rapidly expanding, but people with intellectual disability are at risk for exclusion because sites like Facebook are not designed for cognitive access. The purpose of the present study was to describe the development and initial testing of a cognitively accessible prototype interface for Facebook, called Endeavor Connect, that was designed to support independent Facebook use by people with intellectual disability. The performance of young adults with intellectual disability when completing five common Facebook tasks was compared when using the Endeavor Connect and Facebook interfaces. Results suggest that, when using Endeavor Connect, young adults with intellectual disability completed more tasks independently with fewer errors and required fewer prompts. Implications for research and practice are discussed.
Postsecondary Education Programs for Students With an Intellectual Disability: Facilitators and Barriers to Implementation
Authors: Plotner Anthony J. , Marshall Kathleen J. 
Published: January 2015

Abstract
Financial, legislative, and philosophical support for postsecondary education (PSE) programs for individuals with intellectual disability has resulted in great increases in the number of such programs across the country. Directors of new PSE programs have few research-based guidelines to provide direction for integrating programs within colleges or universities. In this study, we survey administrators of PSE programs for individuals with intellectual disability across the United States in order to identify perceptions of supports and barriers encountered during program development. We also investigated if these supports or barriers changed over time or varied according to type of program. Results suggest that most perceived barriers and supports, with the exception of funding issues, improved over time. Further, there was a significant difference in perceived support from six of the nine identified institutions of higher education IHE collaborative partners from the inception of the program to the present time.
Indandiazocines: unidirectional molecular switches
Authors: Raeker Tim , Hartke Bernd 
Published: January 2015

Abstract
We report theoretical investigations on azobenzene-based indandiazocines, novel chiral systems that perform unidirectional cis ↔ trans isomerizations upon photoexcitation. For three different systems of this kind, we have simulated excited-state surface-hopping trajectories for both isomerization directions, using a configuration-interaction treatment based on system-specifically reparametrized semiempirical AM1 theory. Our results are also compared to experimental and theoretical results for the parent system diazocine. We show that, as intended by design, the trans → cis bending of the azo unit in these indandiazocines can only happen in one of the two possible directions due to steric constraints, which is a new feature for photoswitches and a necessary prerequisite for directional action at the nanoscale.
Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids
Authors: Rut Wioletta , Kasperkiewicz Paulina , Byzia Anna , Poreba Marcin , Groborz Katarzyna , Drag Marcin 
Published: January 2015

Abstract
Substrate specificity of proteases can be determined using several methods among which the most frequently used are positional scanning library, proteomics and phage display. Classic approaches can deliver information about preferences for natural amino acids in binding pockets of virtually all proteases. However, recent studies demonstrate the ability to obtain much more information by application of unnatural amino acids to positional scanning library approaches. This knowledge can be used for the design of more active and specific substrates, inhibitors and activity based probes. In this minireview we describe recent strategies and concepts for the design and application of fluorogenic substrates library tailored for exopeptidases and endopeptidases.