bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With Rivaroxaban
Authors: Zhou Wei , Zorn Markus , Nawroth Peter , Bütehorn Ulf , Perzborn Elisabeth , Heitmeier Stefan , Veltkamp Roland 
Published: January 2013

Background and Purpose—
Rivaroxaban has recently been approved for stroke prevention in atrial fibrillation. However, lack of an effective antidote represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated with rivaroxaban, and to examine the effectiveness of different hemostatic factors in preventing excess hematoma expansion.

Methods—
In C57BL/6 mice receiving 10 or 30 mg/kg rivaroxaban by gastric gavage, plasma concentration, prothrombin time, and coagulation factor activities were measured repeatedly. Thirty minutes after inducing ICH by intrastriatal collagenase-injection, mice received an intravenous injection of either saline, prothrombin complex concentrate (100 U/kg), murine fresh frozen plasma (200 μL), or recombinant human Factor VIIa (1 mg/kg). ICH volume was quantified on brain cryosections and using hemoglobin spectrophotometry 24 hours later.

Results—
Rivaroxaban in 30 mg/kg dose substantially increased the hematoma volume in ICH induced by 0.060 U collagenase. Prothrombin complex concentrate, fresh frozen plasma, or Factor VIIa prevented excess hematoma expansion caused by anticoagulation. Prevention of hematoma expansion by prothrombin complex concentrate was dose-dependent. None of the 3 agents completely corrected the prolonged prothrombin time, although they restored the activities of deficient FII and X.

Conclusions—
Prothrombin complex concentrate, Factor VIIa, and fresh frozen plasma prevent excess intracerebral hematoma expansion in a murine ICH model associated with rivaroxaban. The efficacy and safety of this reversal strategy must be further evaluated in clinical studies.
Increase of clutch size triggers clutch destruction behaviour in common moorhens (Gallinula chloropus) during the incubation period
Authors: Wang Longwu , Yang Canchao , Hsu Yu-Cheng , Antonov Anton , Moksnes Arne , Røskaft Eivin , Liang Wei , Stokke Bård Gunnar 
Published: January 2013

Conspecific brood parasitism (CBP) is common in a variety of animal taxa, including birds. In coots (Fulica spp.), and the closely related moorhens (Gallinula spp.), such parasitism is especially common, and hosts experience considerable costs through increased chick competition soon after hatching. Hence, these birds have evolved egg recognition and rejection abilities, e.g., egg counting, burying the foreign eggs, assigning them suboptimal positions within the mixed clutch, or deserting parasitized clutches. For common moorhens (Gallinula chloropus) it has been shown that desertion of parasitized nests pays most at the early egg laying stage. Later on, the costs of desertion exceed the costs of brood parasitism and acceptance is favoured. Here we tested moorhen egg discrimination behaviour during the incubation stage when acceptance of foreign eggs is expected. Four treatments were applied: (1) single added non-mimetic pale blue egg, (2) single added non-mimetic white chicken egg, (3) four foreign conspecific eggs added to the clutch and (4) four foreign conspecific eggs exchanged for four host eggs. Moorhens responded by egg destruction (47%) only to the increased clutch size but not to foreign egg colour and size match. In three nests where egg destruction occurred, all the eggs in the mixed clutch were destroyed by pecking, in two other nests one of the foreign eggs were pecked, while two other nests were deserted. These results are puzzling since moorhens have been shown to possess refined egg recognition abilities. To our knowledge, such destruction of parasitized clutches by moorhens during incubation has not previously been reported. We suggest that after clutch completion, moorhens use increase in clutch size as a cue to determine if they have been parasitized, and some individuals choose to reject parasitic eggs by deserting or destroying the whole clutch.
Global Capitalism and “North-South” Unevenness: In Light of Ranking, Statistical Correlations, and Profits from the Forbes’ Worldwide List of 2000 Top Firms
Authors: del Castillo-Mussot Marcelo , Sprague Jeb , Garcia Alfredo de la Lama 
Published: January 2013

AbstractWhile a ‘north-south divide’ in world capitalism has been pointed to for many years, in this article we examine how this unevenness continues in today’s epoch of capitalist globalization. To examine this phenomenon, we analyze a recentForbes Magazineannual ranking of the leading 2000 companies in the world (G2000), by grouping or ‘boxing’ these companies by their 62 domiciles to calculate aggregated sales, profits, assets and market value and correlating these quantities with the GDP of the corresponding domicile. This is an approximation to reality, since the variety of transnational capital and associated global processes make it nowadays problematic to assign national labels to capital. Regardless of where the whole business circuit takes place, we found thatthe GDP of each country is directly proportional, more or less, to the economic strength of all G2000 top firms based or registered in that country. These proportionalities tend to hover around a certain level globally, yet the correlation is lower for the ‘global south’ (as some describe it). We can also identify important regional variations of ratios such as profits/sales. Other ratios could also be easily calculated from our results. Together these findings help lead to a more nuanced understanding of transnational corporations (TNCs), but also suggest more basically, for instance, that the ‘global north’ remains to some degree more penetrated by TNCs (of the G2000).
Adorno, Auschwitz, and the New Categorical Imperative
Authors: Ostrove Geoff 
Published: January 2013

Abstract
Theodor Adorno (2001) once claimed, “Hitler has imposed a new categorical imperative upon humanity in the state of their unfreedom: to arrange their thinking and conduct, so that Auschwitz never repeats itself, so that nothing similar ever happen again” (p. 358). In this article I analyze exactly what Adorno meant by this statement, and how he believes humanity should act in order to arrange their thinking, conduct, and communication so that nothing similar to the Holocaust can ever happen again. I will also explore Adorno’s thoughts on why the Holocaust was able to occur, how contemporary society should respond to such a catastrophe, and why he felt the creation of the modern state of Israel was not an appropriate response to the Holocaust. Adorno felt that the only true form of revolutionary praxis was to change the dominant means of production and any lesser form of rebellion was futile and only reified the contemporary commodity-form capitalist system.
The effects of cardiopulmonary bypass and deep hypothermic circulatory arrest on blood viscoelasticity and cerebral blood flow in a neonatal piglet model
Authors: Ündar Akif , Vaughn William K , Calhoon John H 
Published: January 2013

The purpose of this study is to determine the effects of cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) on the viscoelasticity (viscosity and elasticity) of blood and global and regional cerebral blood flow (CBF) in a neonatal piglet model. After initiation of CPB, all animals ( n = 3) were subjected to core cooling for 20 min to reduce the piglets’ nasopharyngeal temperatures to 18°C. This was followed by 60 min of DHCA, then 45 min of rewarming. During cooling and rewarming, the alpha-stat technique was used. Arterial blood samples were taken for viscoelasticity measurements and differently labeled microspheres were injected at pre-CPB, pre- and post-DHCA, 30 and 60 min after CPB for global and regional cerebral blood flow calculations. Viscosity and elasticity were measured at 2 Hz, 22°C and at a strain of 0.2, 1, and 5 using a Vilastic-3 Viscoelasticity Analyzer. Elasticity of blood at a strain = 1 decreased to 32%, 83%, 57%, and 61% ( p = 0.01, ANOVA) while the viscosity diminished 8.4%, 38%, 22%, 26% compared to the baseline values ( p = 0.01, ANOVA) at pre-DHCA, post-DHCA, 30 and 60 min after CPB, respectively. The viscoelasticity of blood at a strain of 0.2 and 5 also had similar statistically significant drops ( p < 0.05). Global and regional cerebral blood flow were also decreased 30%, 66%, 64% and 63% at the same experimental stages ( p < 0.05, ANOVA). CPB procedure with 60 min of DHCA significantly alters the blood viscoelasticity, global and regional cerebral blood flow. These large changes in viscoelasticity may have a significant impact on organ blood flow, particularly in the brain.
Point-of-care testing: inspection preparedness
Authors: Bennett John , Cervantes Cindy , Pacheco Scott 
Published: January 2013

Point-of-care testing (POCT) in the operating room has changed dramatically since the implementation of the Clinical Laboratory Improvement Amendments (CLIA ‘88), which became effective in September 1992. With the implementation of CLIA ‘88, the Health Care Financing Administration (HCFA) mandated that human specimen testing ‘for the purpose of diagnosis, prevention, or treatment of any disease or impairment of, or the assessment of the health of human beings’, must be performed by a certified laboratory or testing site. To attain and maintain accreditation, the need for more stringent and comprehensive documentation has become imperative. The Joint Commission for the Accreditation of Hospitals (JCAHO), the College of American Pathologists (CAPS), HCFA, and state regulatory agencies require data such as staff credentialling, staff training/competency, procedure manuals, quality control logs, quality assurance/corrective action plans, correlation studies, proficiency testing results, and equipment maintenance logs to assure specimens are analyzed in a reliable manner by competent personnel so as not to jeopardize the safety and well being of the patient. Developing a comprehensive, ongoing survey readiness plan that includes a pre-survey checklist of all the documentation required and having this documentation in order and up to date well in advance of the survey will greatly enhance the probability of a successful survey conducted by the various regulatory agencies.
The effects of modified hemofiltration on inflammatory mediators and cardiac performance in coronary artery bypass grafting
Authors: Bog'a Mehmet , Islamog'lu Fatih , Badak Ismail , Çikirikçiog'lu Mustafa , Bakalim Tamer , Yag'di Tahir , Büket Suat , Hamulu Ahmet 
Published: January 2013

Cardiopulmonary bypass increases the blood levels of various immune mediators, thereby leading to a systemic inflammatory response syndrome, e.g. sepsis, with some hemodynamic alterations, such as vasodilatation, tachycardia, and a decrease in systemic vascular resistance. Perioperative hemofiltration is one of the treatment modalities proposed to prevent this syndrome. Modified hemofiltration has been introduced recently by investigators who recommend that the former standard techniques are ineffective in eliminating the inflammatory mediators. The purpose of this study was to determine the effects of the modified technique on these mediators and on hemodynamic parameters. Forty patients undergoing coronary artery bypass grafting were randomized into equal control and hemofiltered groups. The hemodynamic parameters, as well as blood samples, were taken before and after hemofiltration to assess blood concentrations of interleukin-6, interleukin-8 and neopterin. The hemodynamic parameters and immune mediator levels did not differ between the two groups during the course of the study, except in the immediate postoperative periods, where cardiac output, cardiac index, and systemic vascular resistance values were significantly greater in the hemofiltered group while there were no differences in the immune mediators. The results of our study suggest that the effects of modified hemofiltration on immune mediators are still debatable. The improvement found in cardiac performance could be attributed to the prevention of hemodilution and hypervolemia.
A clinical evaluation of platelet function, haemolysis and oxygen transfer during cardiopulmonary bypass comparing the Quantum HF-6700 to the HF-5700 hollow fibre membrane oxygenator
Authors: Chukwuemeka A O , Turtle M RJ , Trivedi U H , Venn G E , Chambers D J 
Published: January 2013

The continued improvement of oxygenators is an important aspect of patient safety during cardiopulmonary bypass (CPB). The purpose of this study was to compare the Bard William Harvey HF-5700 oxygenator to the upgraded Bard Quantum HF-6700, which has recently been introduced into clinical practice. No clinical evaluation of this device has been published to date. The two oxygenators differ principally in that the Quantum has a smaller priming volume, achieved at the expense of a smaller membrane surface area which could result in sub-optimal gas exchange characteristics, increased haemolysis and increased platelet dysfunction during CPB. Twenty adult patients undergoing elective, first time coronary artery bypass grafting (CABG) were randomly assigned either to the HF-5700 ( n=10) or to the HF-6700 ( n=10) group. One patient underwent mitral valve repair in addition to CABG and was excluded from further study. There were no statistically significant differences in either preoperative or operative parameters between the two groups. Samples were obtained at the start of CPB, at 30 min, 60 min, at the end of CPB and at 1 h following termination of CPB. No significant differences between the two groups were found in oxygen transfer, haemolysis (plasma haptoglobin levels) or platelet function (a novel platelet activating factor (PAF)-induced platelet activation test) at any of the time points during CPB. It was concluded that the Quantum HF-6700 matches the HF-5700 for the parameters studied, whilst having the advantage of requiring a smaller priming volume.
Preservation of collagen-induced whole blood platelet aggregation by tranexamic acid therapy in primary cardiac valve surgery
Authors: Miyashita Tetsuya , Kamibayashi Takahiko , Ohnishi Yoshihiko , Kobayashi Junjiro , Kuro Masakazu 
Published: January 2013

Haemostatic disorder is one of the most common complications following cardiac surgery with cardiopulmonary bypass (CPB). Tranexamic acid reduces blood loss and allogeneic blood transfusion requirement in cardiac surgery. It had been thought that tranexamic acid inhibited fibrinolysis alone following CPB. In the present study, the haemostatic effects of tranexamic acid (20 mg/kg body weight bolus after induction of anaesthesia followed by continuous infusion at 2 mg/kg/h), including fibrinolysis and platelet function, were investigated in 22 patients (tranexamic acid group n = 12; control group n = 10) undergoing primary cardiac valve surgery. Fibrinolysis following CPB was reduced significantly in the tranexamic acid group. Following protamine administration, the reduction of collagen-induced whole blood platelet aggregation was mitigated significantly in the tranexamic acid group compared with the control group (36% reduction in the tranexamic acid group vs 58% in the control group; p = 0.011), although platelet counts did not differ between the two groups. In conclusion, tranexamic acid not only inhibits fibrinolysis directly, but also may preserve platelet function following CPB.
Familial antithrombin-III deficiency during cardiopulmonary bypass: a case report
Authors: Brinks H J , Weerwind P W , Verkroost M WA , Nováková I. , Brouwer M HJ 
Published: January 2013

The serine protease inhibitor antithrombin-III (AT-III) is the principal in vivo inhibitor of blood coagulation, inactivating mainly thrombin, but also other serine proteases. Binding of AT-III to heparin dramatically increases its inhibitory effect. AT-III deficiency during cardiopulmonary bypass (CPB) can lead to insufficient anticoagulation which cannot be treated by higher doses of heparin. A 60-year-old male with familial AT-III deficiency was admitted to our hospital for coronary artery bypass surgery and aortic valve replacement. Four days before the operation, acenocoumarol was stopped and anti-Xanadroparincalcium (Fraxiparine) was started. AT-III activity at that time was 56%. Two hours before the operation, a single dose of 4500 IU AT-III concentrate was administered. Heparinization was performed with 400 IU/kg of porcine mucosal heparin, increasing the activated coagulation time (ACT) from a baseline of 115 to 549 s. AT-III activity at that time was above 100% and the plasma D-dimer concentration was 230 ng/l. ACTs during CPB remained above 999 s, whereas the AT-III activity dropped to 54% and the D-dimer increased up to 500 ng/l at the end of CPB. CPB was terminated uneventfully. Heparin was reversed with 3 mg/kg protamine chloride, decreasing the ACT to 155 s. In the intensive care unit (ICU), the patient received prophylactic Fraxiparine and 1500 IU AT-III, increasing the AT-III activity to 84%. Postoperatively, there was continued blood loss, which necessitated the administration of whole blood and eventually re-exploration. The case presented illustrates an uneventful treatment of a patient with a hereditary AT-III deficiency undergoing CPB. In spite of an uneventful treatment with AT-III pre-CPB, administration of prophylactic AT-III concentrate after surgery should be considered with caution, as this might increase the postoperative morbidity.
Cardiac surgical patients exposed to heparin-bonded circuits develop less postoperative cerebral dysfunction than patients exposed to non-heparin-bonded circuits
Authors: Mongero L B , Beck J R , Manspeizer H E , Heyer E J , Lee K , Spanier T A , Smith C R 
Published: January 2013

A prospective randomized trial was used to study the incidence of cerebral dysfunction in patients undergoing cardiopulmonary bypass (CPB) with heparin-bonded vs non-heparin-bonded circuits. Although the etiology of postoperative cerebral dysfunction is controversial, activation of the systemic inflammatory response may play a role. After institutional approval and informed written consent, 39 elective coronary artery bypass (CABG) patients were studied. A battery of neuropsychometric tests (NPMTs) was performed preoperatively, and 5 days and 6 weeks postoperatively. Significant change in NPMT performance was defined as a 25% or greater decrease in postoperative performance, compared to baseline. The number of abnormal tests per patient was calculated. Analysis using the Mann-Whitney rank test was performed for the first follow-up. Patients randomized to heparin-bonded circuits had fewer abnormal NPMTs (>1 abnormal test) on postoperative day 5 (58 vs 70%, n=19 and 20) than patients randomized to non-heparin-bonded circuits. Patients exposed to heparin-bonded circuits had fewer abnormal tests (>1 abnormal test) at 6 weeks (36 vs 63%, n=14 and 16). Results suggested that the attenuation of systemic inflammation by heparin-bonded CPB circuits may lower the incidence of cerebral injury in cardiac surgical patients.
Albumin in the pump prime: its effect on postoperative weight gain
Authors: Zarro Debra L , Palanzo David A , Phillips Theodore G 
Published: January 2013

An investigation was conducted to determine whether adding albumin to the prime of the cardiopulmonary bypass circuit had any effect on postoperative weight gain. Patients undergoing non-emergency myocardial revascularization for coronary artery disease were divided into two groups. Group I (albumin) received 250 ml of 5% human albumin in their pump prime, whereas group II (control) served as controls. The same surgeon, anesthesia technique, perfusion circuit and conduct, and postoperative management were employed for all patients in the study. No statistically significant differences could be found between the groups for any of the variables studied, including fluid intake during surgery and the first 24 h postoperation, urine output, fluid balance and postoperative weight gain. The authors conclude from this investigation that adding 250 ml of 5% human albumin to the pump prime has no effect on postoperative weight gain. The next step could be to examine the effect of using larger amounts of albumin or plasma volume expanders in the pump prime.
A genetically engineered human Kunitz protease inhibitor with increased kallikrein inhibition in an ovine model of cardiopulmonary bypass
Authors: Ohri Sunil K , Parratt Rachel , White Tyler , Becket Jenny , Brannan John J , Hunt Beverley J , Taylor Kenneth M 
Published: January 2013

A recombinant human serine protease inhibitor known as Kunitz protease inhibitor (KPI) wild type has functional similarities to the bovine Kunitz inhibitor, aprotinin, and had shown a potential to reduce bleeding in an ovine model of cardiopulmonary bypass (CPB). The aim of this study was to assess KPI-185, a modification of KPI-wild type that differs from KPI-wild type in two amino acid residues and which enhances anti-kallikrein activity in a further double-blind, randomized study in an ovine model of CPB, and to compare with our previous study of KPI-wild type and aprotinin in the same ovine model. Post-operative drain losses and subjective assessment of wound ‘dryness’ showed no significant differences between KPI-185 and KPI-wild type, despite the significant enhancement of kallikrein inhibition using KPI-185 seen in serial kallikrein inhibition assays. These preliminary findings support the hypothesis that kallikrein inhibition is not the major mechanism by which Kunitz inhibitors such as aprotinin reduce perioperative bleeding.
Life and death of a cardiac myocyte: principles of cellular biology
Authors: Basile-Borgia Annette E , Ware Vassie C 
Published: January 2013

If the future of extracorporeal circulation is to include approaches to enhance localized or widespread distribution of cells, and/or gene transfer for augmentation of cardiac function, it is imperative that we gain an increased understanding of the mechanisms that define the cardiac myocyte phenotype. The purpose of this paper is to review the natural history of the cardiac myocyte. A variety of signals determine the cellular processes that characterize birth, growth, differentiation and death of cardiomyocytes. Examined here are primary aspects of the molecular genetics of growth and development, including signal transduction, protein phosphorylation, the cell division cycle, and transcriptional activation. This review is intended to be an update on insights into molecular aspects of the cell, with emphasis on gene expression during cardiac myogenesis and a discussion of its relevance to the field of extracorporeal circulation. In addition, the current status of research in myogenesis is presented.