bluuebunny/crossref_metadata_2025_split huggingface dataset:
StemRegenin-1 Reverses Drug Resistance of MCF-7/ADR Cells via AhR/ABC Transports and AhR/UGTs Pathways
Authors: Zhang Yang , Ma Yu-Chen , Song Jue , Jin Yong , Bao Yan-Ni 
Published: July 2024

Objectives:
Drug resistance reduces the antitumor efficacy of chemotherapy. Therefore,
it is important to know how to reverse drug resistance. In this work, we investigated drug resistance
reversal by StemRegenin-1(SR-1) in MCF-7/ADR cells and the mechanism by which it exerts
its drug resistance effect.

Methods:
MTT test and protein blot were employed as the two main in vitro cell tests. The cells
were treated with SR-1 and ADM to detect the changes in their proteomics, and then the effects of
AhR downstream proteins, glucuronidase, and drug-resistant proteins were verified. The accumulation
of ADM in the combined cells and its effect on the cell cycle were detected by flow cytometry.
In vivo, a BALB/C mice xenograft test was conducted to observe the anti-tumor effect and
side effects of the drug combination.

Results:
SR-1 combined with ADM inhibited cell proliferation and significantly decreased the expression
of CYP1A1, UGT1A6, P-gP (ABCB1), and MRP1 (ABCC1). Furthermore, SR-1 caused
apoptosis and cell cycle arrest. In vivo experiments showed that SR-1 significantly enhanced the
antitumor effects of ADM and reduced the toxic effects of ADM.

Conclusion:
SR-1 inhibited AhR activity, decreased its downstream protein CYP1A1 and the expression
of UGT1A6, P-gP, and MRP1 in MCF-7/ADR cells, and reversed drug resistance in
MCF-7/ADR cells through AhR/ABC transports and AhR/UGTs pathways.
Synthesis of Various Spiro-pyranooxoindoles Using Vitamin B12 as an Efficient Biocatalyst
Authors: Nadernia Reyhaneh , Marandi Ghasem , Hazeri Nourallah , Maghsoodlou Malek Taher 
Published: July 2024

Introduction:
The present study aims to discuss the synthesis of various spiropyrano-
oxoindole derivatives through a reaction involving isatin, malononitrile, and a CH-acid
source in the presence of vitamin B12.

Materials and Methods:
Eco-friendly solvents were utilized to synthesize the spiro-pyranooxoindole,
resulting in high yields of all synthesized heterocyclic systems. Isatin and malononitrile
were reacted with β-dicarbonyls as CH-acids in the presence of vitamin B12.

Results:
The results indicate that vitamin B12 is highly effective in generating spiro-pyranooxoindole
derivatives. All synthesized compounds closely match previously reported compounds.

Conclusion:
In conclusion, a new and effective method for synthesizing spiro-pyrano-oxoindole
has been demonstrated using vitamin B12 as a biocatalyst.
Evaluation of Influenza Vaccination Coverage Among Healthcare Workers During the COVID-19 Pandemic and Analysis of Motivating and Hindering Factors
Authors: Bazkiaei Mohammad Khedmati , Nouri Majid , Galougahi Mohammad Hassan Kazemi , Mosaddeghkhah Ali , Darvishi Mohammad 
Published: July 2024

Background and Aims:
Influenza, caused by subtypes A and B of the influenza virus, can
lead to mild or severe illness and cause secondary infections. High-risk groups include pregnant
women, the elderly, and young children. Vaccination is the most effective prevention method. This
research aims to evaluate influenza vaccination coverage among healthcare providers during the
COVID-19 pandemic and analyze factors influencing vaccination rates.

Methods:
In this study, a random sample of 440 healthcare providers was selected. Data collection
involved a demographic questionnaire and a researcher-designed questionnaire focusing on influenza
knowledge, reasons for not getting vaccinated, and motivations for vaccine uptake. The questionnaire
included 21 items on hindering factors and 6 on motivating factors. Statistical analysis was
conducted using the Pearson correlation coefficient, and the reliability of the measurement tool was
assessed using Cronbach's alpha.

Results:
In this study, 42% of healthcare providers received the influenza vaccine during the
COVID-19 pandemic, while 58% did not. Prior to the pandemic, only 30.9% had received the vaccine,
compared to 69.1% who had not. Among those not vaccinated during COVID-19, the mean
score for inhibitory factors was significantly higher at 46.9, versus 41.47 for those who were vaccinated.
Vaccination rates varied significantly with age: 41.3% of those under 30 were vaccinated,
34.9% of those aged 30-40, and 54.5% of those over 40. Additionally, 78.9% of the participants were
infected with COVID-19 during the study period.

Conclusion:
The research findings indicate low influenza vaccination coverage among healthcare
providers and the need for further education to increase staff awareness about the importance of vaccination,
change individuals' perceptions of their susceptibility to influenza, and emphasize the effectiveness
of the vaccine in preventing the disease.
Novel Coronavirus: An Overview of the History, Pathophysiology, Diagnosis, and Management of the Pandemic COVID-19 Catastrophe, with Special Emphasis on Herbal Treatment Alternatives
Authors: srivastava Shikha , KS Parihar Arun , Rawat Singh Manju , Singh Deependra , Singh Chauhan Nagendra , Garabadu Debapriya , Yadav Krishna 
Published: July 2024

Abstract:
The crisis of COVID-19 pandemic, has shaken up the whole world with its power of
transmission and unknown treatment strategy. A disease that starts with fever, cold, and cough leads
to extreme fatigue, loss in breathing capacity, alveolar damage, and eventual death. The disease
forced human beings to stay at home to protect humankind. Due to the serious nature of this COVID-
19 pandemic, humankind was forced to understand the plausible cause and methods to reduce the
spread and find out the best possible therapeutic regimen. Thus, the present review provided new
insight into the history, symptoms, pathogenesis, diagnosis, clinical research, and follow-up treatment
strategies of COVID-19. Further, In order to deal with such a pandemic situation, we have even
introduced a novel concept of natural therapy based on medicinal plants for repurposing it as potential
as a therapeutic warrior against COVID-19.
Differences in eHealth Access, Use, and Perceived Benefit Between Different Socioeconomic Groups in the Dutch Context: Secondary Cross-Sectional Study
Authors: Standaar Lucille , van Tuyl Lilian , Suijkerbuijk Anita , Brabers Anne , Friele Roland 
Published: July 2024

Background
There is a growing concern that digital health care may exacerbate existing health disparities. Digital health care or eHealth encompasses the digital apps that are used in health care. Differences in access, use, and perceived benefits of digital technology among socioeconomic groups are commonly referred to as the digital divide. Current research shows that people in lower socioeconomic positions (SEPs) use eHealth less frequently.

Objective
This study aims to (1) investigate the association between SEP and eHealth access to, use of, and perceived benefit within the adult Dutch population and (2) evaluate disparities in eHealth access, use, and perceived benefit through three socioeconomic variables—education, standardized income, and the socioeconomic status of the neighborhood.

Methods
A secondary analysis was conducted on data from the Nivel Dutch Health Care Consumer Panel (response rate 57%, 849/1500), to assess access to, use of, and perceived benefits from eHealth. These data were collected to monitor eHealth developments in the Netherlands. eHealth was examined through two concepts: (1) eHealth in general and (2) websites, apps, and wearables. Results were stratified into 9 SEP populations based on 3 indicators—education, standardized income, and socioeconomic status level of the neighborhood. Logistic regression analyses were performed to evaluate whether the outcomes varied significantly across different SEP groups. Age was included as a covariate to control for confounding.

Results
This study confirms the association between eHealth and SEP and shows that low SEP respondents have less access (odds ratio [OR] 5.72, 95% CI 3.06-10.72) and use (OR 4.96, 95% CI 2.66-9.24) of eHealth compared to medium or high SEP respondents. Differences were most profound when stratifying for levels of education.

Conclusions
The access to and use of eHealth has a socioeconomic gradient and emphasizes that SEP indicators cannot be used interchangeably to assess eHealth access and use. The results underline the importance of activities and policies aimed at improving eHealth accessibility and usage among low SEP groups to mitigate disparities in health between different socioeconomic groups.
The Association Between Solid Fuel Use and Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in Sichuan, China: Cross-Sectional Study
Authors: Yuan Qiming , Zhou Xianghong , Ma Li , Cai Boyu , Zhang Zilong , Deng Linghui , Hu Dan , Jiang Zhongyuan , Wang Mingda , Wei Qiang , Qiu Shi 
Published: July 2024

Abstract

Background
Benign prostatic hyperplasia (BPH) is a global age-related disease. It has been reported that over half of the Chinese male population aged 70 years or older are experiencing BPH. Solid fuel, which is the major source of household air pollution, has been reportedly associated with several adverse events, including sex hormone disorders. Due to the certain relationship between sex hormone levels and prostate disease, the relationship between solid fuel use and lower urinary tract symptoms (LUTSs) suggestive of BPH (LUTS/BPH) deserves further exploration.

Objective
This study mainly aimed to investigate the association between solid fuel use and LUTS/BPH.

Methods
The data used in this study were obtained from the West China Natural Population Cohort Study. Household energy sources were assessed using questionnaires. LUTS/BPH was evaluated based on participant self-reports. We performed propensity score matching (PSM) to reduce the influence of bias and unmeasured confounders. The odds ratio (OR) and 95% CI of LUTS/BPH for the solid fuel group compared with the clean fuel group were calculated. We also conducted stratified analyses based on BMI, metabolic syndrome, waist to hip ratio, drinking status, smoking status, and age.

Results
A total of 5463 participants were included in this study, including 399 solid fuel users and 5064 clean fuel users. After PSM, the solid fuel group included 354 participants, while the clean fuel group included 701 participants. Solid fuel use was positively correlated with LUTS/BPH before and after PSM (OR 1.68, 95% CI 1.31‐2.15 and OR 1.81, 95% CI 1.35‐2.44, respectively). In stratified analyses, the OR of the nonsmoking group was higher than that of the smoking group (OR 2.56, 95% CI 1.56‐4.20 and OR 1.47, 95% CI 0.99‐2.18, respectively). Similarly, the OR of the nondrinking group was higher than that of the drinking group (OR 2.70, 95% CI 1.46‐4.99 and OR 1.48, 95% CI 1.01‐2.17, respectively).

Conclusions
A positive correlation between solid fuel use and LUTS/BPH was observed. The results suggest that improving fuel structure for household cooking and other household needs can possibly help reduce the risk of LUTS/BPH.
Data Lake, Data Warehouse, Datamart, and Feature Store: Their Contributions to the Complete Data Reuse Pipeline
Authors: Lamer Antoine , Saint-Dizier Chloé , Paris Nicolas , Chazard Emmanuel 
Published: July 2024

Abstract
The growing adoption and use of health information technology has generated a wealth of clinical data in electronic format, offering opportunities for data reuse beyond direct patient care. However, as data are distributed across multiple software, it becomes challenging to cross-reference information between sources due to differences in formats, vocabularies, and technologies and the absence of common identifiers among software. To address these challenges, hospitals have adopted data warehouses to consolidate and standardize these data for research. Additionally, as a complement or alternative, data lakes store both source data and metadata in a detailed and unprocessed format, empowering exploration, manipulation, and adaptation of the data to meet specific analytical needs. Subsequently, datamarts are used to further refine data into usable information tailored to specific research questions. However, for efficient analysis, a feature store is essential to pivot and denormalize the data, simplifying queries. In conclusion, while data warehouses are crucial, data lakes, datamarts, and feature stores play essential and complementary roles in facilitating data reuse for research and analysis in health care.
Analyzing the Influence of Video Game and Music Engagement on Technical Skills Acquisition in Dental Students in Preclinical Phase: Protocol for a Prospective, Controlled, Longitudinal Study
Authors: Clouet Roselyne , Gaudin Alexis , Tourtelier Jeanne , Gogendeau Claire , Serisier Samuel , Prud'homme Tony 
Published: July 2024

Background
The practice of dental surgery requires a few different skills, including mental rotation of an object, precision of movement with good hand-eye coordination, and speed of technical movement. Learning these different skills begins during the preclinical phase of dental student training. Moreover, playing a musical instrument or video game seems to promote the early development of these skills. However, we found that studies specifically addressing this issue in the field of dental education are lacking.

Objective
The main aims of this study are to evaluate whether the ability to mentally represent a volume in 3D, the precision of gestures with their right and left hand, or the speed of gesture execution is better at baseline or progresses faster for players (video games or music or both).

Methods
A prospective monocentric controlled and longitudinal study will be conducted from September 2023 and will last until April 2025 in the Faculty of Dental Surgery of Nantes. Participants were students before starting their preclinical training. Different tests will be used such as Vandenberg and Kuse’s mental rotation test, the modified Precision Manual Dexterity (PMD), and performing a pulpotomy on a permanent tooth. This protocol was approved by the Ethics, Deontology, and Scientific Integrity Committee of Nantes University (institutional review board approval number IORG0011023).

Results
A total of 86 second-year dental surgery students were enrolled to participate in the study in September 2023. They will take part in 4 iterations of the study, the last of which will take place in April 2025.

Conclusions
Playing video games or a musical instrument or both could be a potential tool for initiating or facilitating the learning of certain technical skills in dental surgery.

International Registered Report Identifier (IRRID)
DERR1-10.2196/55738
Strategi Manajemen Shift Work Disorder (SWD) untuk Perawat Rumah Sakit: Sistematik Review
Authors: Rizany Ichsan , Handiyani Hanny , Pujasari Hening , Erwandi Dadan , Wulandari Cicilia Ika , Gayatri Dewi 
Published: July 2024

Latar Belakang: Shift Worker Disorder (SWD) masih menjadi masalah sampai saat ini. Perkiraan prevalensi gangguan kerja shift (SWD) bervariasi antara 5 - 35,2%. Banyak dampak yang diakibatkan oleh SWD kepada perawat.Tujuan: Penelitian bertujuan melakukan analisis tentang strategi manajemen shift work disorder (SWD) untuk perawat di rumah sakit.Metode: l Desain penelitian ini adalah systematik review menggunakan diagram alur PRISMA. Peneliti menggunakan PICOs dan mencari artikel bahasa inggris yang diterbitkan dari tahun 2018 sampai dengan Maret 2023. Database yang digunakan meliputi ProQuest, MEDLINE, Embase, Scopus, PubMed, ClinicalKey Nursing, Science Direct, dan Taylor & Francis. Peneliti memanfaatkan tool Covidence untuk proses seleksi data sampai dengan ekstraksi serta menggunakan instrument the Joanna Briggs Institute (JBI) untuk mengevaluasi artikel.Hasil: Sepuluh artikel telah diidentifikasi dan dianalisis. Ukuran sampel dari studi dilaporkan berkisar dari 16 sampai dengan 4275 yang dilakukan di berbagai wilayah geografis. Perawat bisa melakukan manajemen stres, menerapkan sleep hygiene, dan terapi perilaku kognitif untuk mengurangi SWD. Manajemen jadwal dinas, dukungan social dan pengaturan cahaya lingkungan menjadi poin yang dapat diperhatikan di level organisasi oleh manajer rumah sakit dalam membantu mengurangi SWD.Kesimpulan: Strategi untuk manajemen SWD dapat melalui sleep hygiene, pengaturan cahaya lingkungan, terapi perilaku kognitif, dukungan sosial, manajemen stres, dan penjadwalan dinas.
Analisis Penerapan Model Pembelajaran Problem Based Learning Pada Materi Sistem Gerak Manusia Kelas XI SMA Swasta Imelda Medan
Authors: Hasibuan Agrivina Nabilah , Rebista Niken , Manurung Rina Sara Jantri , Arwita Widya 
Published: July 2024

This research was carried out with the aim of describing the implementation of the Problem Based Learning learning model, in the human movement system material for class XI MIA at Imelda Private High School Medan. The population used in this research was all class is qualitative research where the teacher becomes a resource in obtaining information. Data collection is through a process of observation, interviews, documentation and literature study. The results of the research show that the curriculum demands that are being implemented at Imelda Medan Private High School are still the 2013 curriculum so that teachers have limited time and flexibility to implement the PBL method effectively. This causes teachers not to be ready to implement problem-based learning (PBL), so training and professional development is needed and curriculum revision is needed to support the implementation of PBL by including topics with problems that are relevant to real life and school policies must be made to support PBL, including time allocation. enough in the learning schedule.
Abstrak. Penelitian ini dilakukan bertujuan untuk mendeskripsikan pengimplementasian model pembelajaran problem based learning, bagaimana penerapan yang dilakukan guru serta kendala yang menjadi faktor yang mempengaruhi proses pelaksanaannya pembelajaran biologi pada materi sistem gerak manusia kelas XI MIA di SMA Swasta Imelda Medan T.P. 2023/2024. Populasi yang digunakan dalam penelitian ini adalah seluruh siswa kelas XI dan sampel yang diambil adalah kelas XI MIA 1. Jenis penelitian ini merupakan penelitian kualitatif dimana guru menjadi narasumber dalam memperoleh informasi. Pengumpulan data melalui proses pelaksanaan observasi, wawancara, dokumentasi, dan studi literatur. Hasil penelitian menunjukkan bahwa tuntutan kurikulum yang sedang diterapkan di SMA Swasta Imelda Medan T.P 2023/2024 yaitu masih berkurikulum 2013 sehingga guru memiliki keterbatasan waktu dan fleksibilitas untuk menerapkan metode PBL efektif. Hal ini menyebabkan guru belum siap menerapkan pembelajran berbasis masalah (PBL) sehingga dibutuhkan pelatihan dan pengembangan profesional serta diperlukannya perevisian kurikulum agar mendukung penerapan PBL dengan menyertakan topik-topik dengan masalah yang relavan dengan kehidupan nyata serta kebijakan sekolah harus dibuat untuk mendukung PBL termasuk alokasi waktu yang cukup dalam jadwal pembelajaran.
Comments of the Auditing Standards Committee of the Auditing Section of the American Accounting Association on the PCAOB’s Proposal on Firm and Engagement Metrics
Authors: Barr-Pulliam Dereck , Boland Colleen M. , Christensen Brant E. , Hermanson Dana R. , Keyser John D. , Prewett Kyleen W. , Pyzoha Jonathan S. 
Published: July 2024

SUMMARY
On April 9, 2024, the Public Company Accounting Oversight Board (the Board or PCAOB) issued a request for comment on its proposal Firm and Engagement Metrics (PCAOB 2024a). This comment letter summarizes the views of the participating members of the Auditing Standards Committee of the Auditing Section of the American Accounting Association. We commend the PCAOB for its efforts to promote audit quality by emphasizing firm and engagement metrics. Based on our evaluation of the proposal, we offer some overall observations, key takeaways from academic research, and perspectives on the PCAOB’s economic analysis.
Unresolved Financial Reporting Issues: Opportunities for International Accounting Research
Authors: Barth Mary E. 
Published: July 2024

ABSTRACT
This article identifies unresolved financial reporting issues that research can help resolve and provides examples of how adopting an international perspective can deepen the insights obtained from the research. Some of the issues pertain to well-established literatures—intangible assets, risk and uncertainty, fair value accounting, conservatism, and earnings management. Others are relatively new—namely, sustainability, particularly climate change, and digital assets, particularly crypto assets. Addressing these issues could require a reconsideration of the concepts underlying accounting standards, including thinking more broadly about accounting information to encompass more than information in financial statements, including more nonfinancial information. Regardless, there are many opportunities for international accounting research to address open questions these issues raise to provide insights into how global financial accounting and reporting might be improved.
Analisis Kesalahan Berbahasa Bidang Wacana pada Media Tulis Poster Berbasis Digital
Authors: Rahma Annisa Fitria , Fadya Azzahra Kusumaning Sekar , Febriani Rizkyqa Nor , Dewi Rostini Komala , Pratama Tian Bayu 
Published: July 2024

Tujuan penelitian ini adalah untuk mendeskripsikan kesalahan berbahasa di bidang wacana pada media tulis poster berbasis digital. Penelitian ini menggunakan metode deskriptif yang melalui dua tahap yaitu tahap pengumpulan data dan analisis data. Subjek penelitian yang dipilih yaitu poster yang ada pada media berbasis digital. Adapun objek yaitu analisis kesalahan berbahasa Indonesia di bidang wacana. Hasil yang diperoleh dari penelitian ini adalah ditemukan sebanyak 2 data kesalahan penggunaan pengacuan, 1 data kesalahan penyulihan, 1 data kesalahan ketidakefektifan, 1 data kesalahan penggunaan konjungsi, 1 data kesalahan menyimpang dari kaidah kebahasaan, dan 1data kesalahan ketaksaan. Kata Kunci: kesalahan berbahasa, wacana, media tulis, poster digital
The influence of different methods of under-vine management on the structure of vegetation and the qualitative parameters of the grapes in the Moravian wine region
Authors: Kopta Tomáš , Ragasová Lucia Nedorost , Sotolář Radek , Sedláček Jozef , Ferby Vojtěch , Hurajová Erika , Winkler Jan 
Published: July 2024

ABSTRACT
The present article explores the importance of vineyard soil management. Studies on under-vine management have yielded a wide range of results, with some indicating potential benefits for vine growth and productivity. However, the methods of under-vine management and their specific effects on vineyard parameters require further research. The aim of this study is to evaluate the relationships existing between the different types of management of under-vine areas and the vegetation grown in this zone and to determine the effects of under-vine management on the yield and quality of Traminer grapevines. By examining various approaches, the research aims to provide insights into the optimising of vineyard management methods to achieve enhanced biodiversity and grape quality in this specific geographical context. The findings indicated that management of the under-vine area can impact the composition of plants, grape yield and quality. Under-row management had an effect on the number of plant species and their composition. The highest weight of bunches was found in MIX (a species from the Fabaceae family), while the lowest was found in the MECH treatment (bare soil). MULCH, MONO and MIX consistently had higher yeast assimilable nitrogen (YAN) in grapes than other treatments. In many of the evaluated parameters, the influence of the seasons was evident.