bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terminal and Bridging Parent Amido 1,5‐Cyclooctadiene Complexes of Rhodium and Iridium
Authors: Mena Inmaculada , Jaseer E. A. , Casado Miguel A. , García‐Orduña Pilar , Lahoz Fernando J. , Oro Luis A. 
Published: March 2013

AbstractThe ready availability of rare parent amido d8complexes of the type [{M(μ‐NH2)(cod)}2] (M=Rh (1), Ir (2); cod=1,5‐cyclooctadiene) through the direct use of gaseous ammonia has allowed the study of their reactivity. Both complexes1and2exchanged the di‐olefines by carbon monoxide to give the dinuclear tetracarbonyl derivatives [{M(μ‐NH2)(CO)2}2] (M=Rh or Ir). The diiridium(I) complex2reacted with chloroalkanes such as CH2Cl2or CHCl3, giving the diiridium(II) products [(Cl)(cod)Ir(μ‐NH2)2Ir(cod)(R)] (R=CH2Cl or CHCl2) as a result of a two‐center oxidative addition and concomitant metal–metal bond formation. However, reaction with ClCH2CH2Cl afforded the symmetrical adduct [{Ir(μ‐NH2)(Cl)(cod)}2] upon release of ethylene. We found that the rhodium complex1exchanged the di‐olefines stepwise upon addition of selected phosphanes (PPh3, PMePh2, PMe2Ph) without splitting of the amido bridges, allowing the detection of mixed COD/phosphane dinuclear complexes [(cod)Rh(μ‐NH2)2Rh(PR3)2], and finally the isolation of the respective tetraphosphanes [{Rh(μ‐NH2)(PR3)2}2]. On the other hand, the iridium complex2reacted with PMe2Ph by splitting the amido bridges and leading to the very rare terminal amido complex [Ir(cod)(NH2)(PMePh2)2]. This compound was found to be very reactive towards traces of water, giving the more stable terminal hydroxo complex [Ir(cod)(OH)(PMePh2)2]. The heterocyclic carbene IPr (IPr=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene) also split the amido bridges in complexes1and2, allowing in the case of iridium to characterize in situ the terminal amido complex [Ir(cod)(IPr)(NH2)]. However, when rhodium was involved, the known hydroxo complex [Rh(cod)(IPr)(OH)] was isolated as final product. On the other hand, we tested complexes1and2as catalysts in the transfer hydrogenation of acetophenone withiPrOH without the use of any base or in the presence of Cs2CO3, finding that the iridium complex2is more active than the rhodium analogue1.
A Highly Efficient and Selective Aerobic Cross‐Dehydrogenative‐Coupling Reaction Photocatalyzed by a Platinum(II) Terpyridyl Complex
Authors: Zhong Jian‐Ji , Meng Qing‐Yuan , Wang Ge‐Xia , Liu Qiang , Chen Bin , Feng Ke , Tung Chen‐Ho , Wu Li‐Zhu 
Published: March 2013

AbstractThanks to the superior redox potential of platinum(II) complex compared with that of Ru(bpy)32+ in the excited state, an efficient and selective visible‐light‐induced CDC reaction has been developed by using a catalytic amount (0.25 %) of 1. With the aid of FeSO4 (2 equiv), the corresponding amide could not be detected under visible‐light irradiation (λ=450 nm), but the desired cross‐coupling product was exclusively obtained under ambient air conditions. A spectroscopic study and product analysis revealed that the CDC reaction is initiated by photoinduced electron‐transfer from N‐phenyltetrahydroisoquinoline to the complex. An EPR (electron paramagnetic resonance) experiment provides direct evidence on the generation of superoxide radical anion (O2−.) rather than singlet oxygen (1O2) under irradiation of the reaction system, in contrast to that reported in the literature. Combined, the photoinduced electron‐transfer and subsequent formation of superoxide radical anion (O2−.) results in a clean and facile transformation.
Left Atrial Function Assessed by Doppler Echocardiography Rather Than Left Atrial Volume Predicts Recurrence in Patients With Paroxysmal Atrial Fibrillation
Authors: Yoon Ji Hyun , Moon Jeonggeun , Chung Hye moon , Choi Eui‐Young , Kim Jong‐Youn , Min Pil‐ki , Yoon Young‐won , Lee Byoung‐kwon , Hong Bum‐kee , Kwon Hyuck‐moon , Rim Se‐Joong 
Published: March 2013

AbstractBackgroundParoxysmal atrial fibrillation (PaAF) may present as a single self‐terminating episode of atrial fibrillation (AF) or a more persistent form after sinus conversion. We investigated predictors of recurrence in patients with PaAF.HypothesisLeft atrial function would be an useful parameter for predicting PaAF recurrence.MethodsThe study population included 228 PaAF patients (131 males, age 64 ± 14 years) who underwent transthoracic echocardiography immediately after spontaneous sinus conversion at initial AF diagnosis. We followed the study patients for AF recurrence.ResultsAF recurrence was demonstrated in 45 patients (20%, age 68 ± 13 years) after spontaneous sinus conversion. Patients with recurrence had larger left atrial volume index (32 ± 12 vs 25 ± 10 mL/m2, P < 0.001), left ventricle mass index (107 ± 34 vs 93 ± 25 g/m2, P = 0.012), and left ventricle filling pressure (E/e′′) (14 ± 7 vs 12 ± 5, P = 0.012), whereas early diastolic mitral annular velocity (e′) (5 ± 2 vs 6 ± 3 cm/s, P = 0.021), late diastolic mitral annular velocity (A′) (7 ± 3 vs 9 ± 2 cm/s, P < 0.001), and peak systolic mitral annular velocity (7 ± 2 vs 8 ± 2 cm/s, P = 0.045) were significantly lower. In multivariate Cox regression analysis detecting independent predictors of PaAF recurrence, lower A′ (hazard ratio: 0.623, 95% confidence interval: 0.476‐0.815, P = 0.001) was a significant predictor of AF recurrence.ConclusionsA′, which indicates left atrial (LA) contractile function after sinus conversion, was the independent predictor of PaAF recurrence, whereas LA volume was not. LA function may be more important than LA volume in predicting recurrence particularly in patients with PaAF.
Cholesterol Levels and the Association of Statins With In‐Hospital Mortality of Myocardial Infarction Patients Insights From a Chilean Registry of Myocardial Infarction
Authors: Martínez Gonzalo , Rigotti Attilio , Acevedo Mónica , Navarrete Carlos , Rosales Juanita , Giugliano Robert P. , Corbalán Ramón 
Published: March 2013

AbstractBackgroundHypercholesterolemia is a strong risk factor for myocardial infarction (MI). There is scarce information regarding lipoprotein levels among patients with MI in Latin America as well as about the association of very early statin therapy during the course of acute MI.HypothesisVery early statin prescription might be associated with a reduction on in‐hospital mortality in MI patients with nearly normal lipid levels.MethodsProspective registry database analysis of MI patients admitted between 2001 and 2007 at a single university hospital from which demographics, treatments, clinical variables, and mortality were assessed. Patients naïve to statin therapy were divided in 2 groups, according to whether they received (group A) or did not receive (group B) statins during the first 24 hours after admission.ResultsIn the 1465 patients analyzed, mean plasma levels of total cholesterol, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol (HDL‐C) were 197, 117, and 44 mg/dL, respectively, and 41.8% had HDL‐C ≤40 mg/dL. Among statin naïve patients (n = 1272), 67% were classified in group A and 33% in group B. Overall in‐hospital mortality was 4.1%: 1.8% in group A and 8.5% in group B. In the multivariate analysis, including propensity score for statin prescription, the odds ratio for in‐hospital mortality for group A was 0.971 (95% confidence interval: 0.944‐0.999, P = 0.04).ConclusionsIn the Chilean registry of MI patients, low HDL‐C was the main lipid disturbance. Very early statin use after MI appears to be associated with a borderline significant and independent reduction of in‐hospital mortality.
Spatial Pattern of Benthic Diatoms and Water Quality Assessment Using Diatom Indices in a Subtropical River, China
Authors: Tan Xiang , Ma Peiming , Xia Xiaoling , Zhang Quanfa 
Published: March 2013

AbstractBenthic algae including benthic diatoms are one of the most vital primary producers in riverine ecosystems, and their spatial distribution and assemblage structure respond sensitively to various environmental variables. Thus, benthic diatoms have been widely used as indicators of water quality in riverine systems. Here, we present a study on benthic diatoms and water quality assessment using diatom indices in the upper Han River, a subtropical river with a length of 925 km in China. Canonical correspondence analysis indicated that spatial patterns of diatom assemblages could be primarily explained by dissolved organic carbon, pH, major ions, and flow velocity. Two‐way indicator species analysis on the diatom assemblages grouped the sampling sites into those from mainstream and tributaries. There were also significant differences in the Shannon–Wiener diversity index, evenness index, species richness, and diatom indices between the mainstream and tributary sites, and diatom indices categorized the mainstream as mesotrophic and the tributaries as oligo‐mesotrophic in the upper Han River. Lower water quality in the mainstream led to the dominance of pollution tolerant species such as Eolimna subminuscula, while tributaries were characterized by Achnanthidium pyrenaicum and A. subatomus. The research demonstrates the applicability of diatom indices for water quality and ecohealth assessment in subtropical rivers.
Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma
Authors: Saito Yuki , Yoshida Masafumi , Ushiku Tetsuo , Omura Go , Ebihara Yasuhiro , Shimono Toshiyuki , Fukayama Masashi , Yamasoba Tatsuya , Asakage Takahiro 
Published: March 2013

BACKGROUNDThe prevalence and prognostic value of human papillomavirus‐related oropharyngeal squamous cell carcinoma (OPSCC) in Japan has not been evaluated.METHODSOver a 12‐year period, the authors used immunohistochemistry to evaluate the expression of p16 (a cyclin‐dependent kinase inhibitor and tumor suppressor) in samples from 173 patients with OPSCC at a single institution and to determine its prevalence and influence on disease prognosis.RESULTSThe prevalence of p16‐positive OPSCC was 33.7% in tonsillar carcinoma, 28.6% in tongue base carcinoma, 0% in posterior wall carcinoma, and 18.8% in soft palate carcinoma. The prevalence of p16‐positive OPSCC tumors increased from 15.2% during 2000 to 2003 up to 33.3% during 2008 to 2011; during the same periods, among nonsmokers, the prevalence of p16‐positive OPSCC tumors increased from 21.2% to 27.8%; and, among nondrinkers, prevalence increased from 6.1% to 25%. Multivariate analysis identified p16 expression and alcohol consumption as significant, independent prognostic markers of OPSCC.CONCLUSIONSThe current results suggest that the incidence of human papillomavirus‐related OPSCC in Japan is increasing and indicate that p16 expression and alcohol consumption may be significant prognostic markers of survival for patients with OPSCC in Japan. Cancer 2013;119:2005–2011. © 2013 American Cancer Society.
Autoionization of Molecular Hydrogen: Where do the Fano Lineshapes Go?
Authors: Palacios Alicia , Feist Johannes , González‐Castrillo Alberto , Sanz‐Vicario José Luis , Martín Fernando 
Published: March 2013

AbstractAtomic autoionization following photoabsorption is a typical example of quantum interferences governed by electron–electron correlation. Coherence between direct photoionization and autoionization paths results in “Fano profiles”, widely explored in atoms in the last 60 years. The advent of femto‐ and attosecond laser technology made time‐resolved images of the delayed electron ejection in autoionization accessible, leading to the reemergence of such studies in atomic systems. The counterpart molecular phenomena show the richness, as well as the complexity, added by nuclear motion, which may proceed on similar time scales. However, Fano profiles are usually absent in measured molecular photoionization cross sections and an unequivocal parametrization of molecular autoionization signatures, similar to that introduced by Fano in atoms [U. Fano, Phys. Rev. 1961, 124, 1866] has not yet been achieved. In this work we introduce a simple semiclassical model that accounts for all the features observed in H2 photoionization and demonstrate that the interference structures observed in dissociative ionization spectra are almost exclusively due to the phase accumulated in the nuclear motion. Furthermore, we show that the temporal build‐up of these structures in the energy‐differential cross sections is also determined by nuclear motion. We validate our models by comparing with full‐dimensional ab initio calculations solving the time‐dependent Schrödinger equation.
Effects of Dialectical Behaviour Therapy‐Mindfulness Training on Emotional Reactivity in Borderline Personality Disorder: Preliminary Results
Authors: Feliu‐Soler Albert , Pascual Juan C. , Borràs Xavier , Portella Maria J. , Martín‐Blanco Ana , Armario Antonio , Alvarez Enric , Pérez Víctor , Soler Joaquim 
Published: March 2013

Emotional dysregulation has been proposed as a hallmark of borderline personality disorder (BPD). Mindfulness techniques taught in dialectical behaviour therapy (DBT) appear to be effective in reducing affective symptoms and may enhance emotion regulation in BPD patients. In the present study, we assessed whether 10 weeks of DBT‐mindfulness (DBT‐M) training added to general psychiatric management (GPM) could improve emotion regulation in BPD patients. A total of 35 patients with BPD were included and sequentially assigned to GPM (n = 17) or GPM plus DBT‐M (n = 18). Participants underwent a negative emotion induction procedure (presentation of standardized unpleasant images) both pre‐intervention and post‐intervention. Clinical evaluation was also performed before and after treatment. No differences were observed in emotional response at the post‐treatment session. However, patients in the DBT‐M group showed greater improvement in clinical symptoms. Formal mindfulness practice was positively correlated with clinical improvements and lower self‐reported emotional reactivity. Our preliminary results suggest that mindfulness training reduces some psychiatric symptoms but may not have a clear effect on how patients respond to emotional stimuli in an experimental setting. Copyright © 2013 John Wiley & Sons, Ltd.Key Practitioner Message

No clear effect of mindfulness training was observed on emotional response to a negative emotion induction procedure.
Application of the DBT‐M module jointly to GPM induced better clinical outcomes than GPM alone.
Formal mindfulness practice showed a positive impact on emotion regulation and clinical improvement.
Novel grounded inductance simulator using single OTRA
Authors: Pandey Rajeshwari , Pandey Neeta , Paul Sajal K. , Singh Ajay , Sriram B. , Trivedi Kaushlendra 
Published: March 2013

ABSTRACTIn this paper, a method to realize a grounded inductor using single operational transresistance amplifier is presented. The simulated inductance value can be controlled independent of realizability condition. The non‐ideality analysis of the circuit is also given. The workability of the proposed simulated inductance is demonstrated through two applications namely, a band pass filter and an oscillator. PSPICE simulation and experimental results agree well with the theoretical values. Copyright © 2013 John Wiley & Sons, Ltd.
Intracellular protein and nucleic acid measured in eight cell types using deep‐ultraviolet mass mapping
Authors: Cheung Man C. , LaCroix Rebecca , McKenna Brian K. , Liu Ling , Winkelman James , Ehrlich Daniel J. 
Published: March 2013

AbstractWe present measurements by deep‐ultraviolet mass mapping of nucleic acid (NA) and protein for five commonly cultured and three primary cell types. The dry mass distribution at submicron resolution was determined on a single‐cell basis for 250–500 cells from each of these types. Since the method carries a direct reference to a spectrophotometric standard (molar extinction coefficient), we are able to calibrate the absolute weight distributions both on a cell‐to‐cell basis within each type and across types. We also provide a calibration in absolute mass units for fluorescence‐based measurements (flow cytometry and fluorescence microscopy). As might be expected the cultured cell lines show a high concentration of nucleic acids in the nuclear compartment, much larger than the genomic 2C number even in the G1 stage. The whole‐cell nucleic‐acid/protein ratio was found to be a characteristic of cell lines that persists independent of cell cycle and, as a result, this ratio has some value for phenotyping. Primary chicken red blood cells (cRBC), often used as a cytometry standard, were determined to have a nuclear‐isolated nucleic acid content much closer to the genomic number than the cultured cell lines (cRBC: 3.00 pg total NA, 2.30 pg DNA, and 0.70 pg RNA). The individual blastomeres (n = 54) from mouse embryos at eight‐cell stage were measured and found to vary by more than a factor or two in total protein and nucleic acid content (0.8–2.3 ng total protein, 70–150 pg total NA). The ratio of nucleic acid to protein was more nearly constant for each blastomere from a particular embryo and this ratio was found to be an identifying characteristic that varies from embryo to embryo obtained from a single flushing of a mouse. © 2013 International Society for Advancement of Cytometry
Species‐time‐area and phylogenetic‐time‐area relationships in tropical tree communities
Authors: Swenson Nathan G. , Mi Xiangcheng , Kress W. John , Thompson Jill , Uriarte María , Zimmerman Jess K. 
Published: March 2013

AbstractThe species‐area relationship (SAR) has proven to be one of the few strong generalities in ecology. The temporal analog of the SAR, the species‐time relationship (STR), has received considerably less attention. Recent work primarily from the temperate zone has aimed to merge the SAR and the STR into a synthetic and unified species‐time‐area relationship (STAR) as originally envisioned by Preston (1960). Here we test this framework using two tropical tree communities and extend it by deriving a phylogenetic‐time‐area relationship (PTAR). The work finds some support for Preston's prediction that diversity‐time relationships, both species and phylogenetic, are sensitive to the spatial scale of the sampling. Contrary to the Preston's predictions we find a decoupling of diversity‐area and diversity‐time relationships in both forests as the time period used to quantify the diversity‐area relationship changes. In particular, diversity‐area and diversity‐time relationships are positively correlated using the initial census to quantify the diversity‐area relationship, but weakly or even negatively correlated when using the most recent census. Thus, diversity‐area relationships could forecast the temporal accumulation of biodiversity of the forests, but they failed to “back‐cast” the temporal accumulation of biodiversity suggesting a decoupling of space and time.
Turning‐on the Quenched Fluorescence of Azomethines through Structural Modifications
Authors: Barik Satyananda , Skene William G. 
Published: March 2013

AbstractA series of fluorene azomethines were prepared to examine the effect of structural modification on the absolute fluorescence quantum yields (Φfl). The change in fluorescence occurring upon reversing the orientation of the azomethine bond, the number of fluorene units, and alkylation at the 9,9′‐positions of fluorene was examined. It was found that Φfl could be tailored with these structural modifications with 0.05 ≤ Φfl ≤ 0.45. The highest Φfl was measured for the trimer derived from 2,7‐diamino fluorene with each fluorene being alkylated at the 9,9′‐positions. The fluorescence quantum yields did not increase at 77 K, implying the absence of fluorescence quenching modes involving internal conversion. Fluorescence enhancement was also not observed upon protonating the imine with trifluoroacetic acid. This confirms that Waldon inversion and isomerization are not fluorescence deactivation modes. Additionally, no photoisomerization was observed either at room temperature or at 77 K when the fluorene derivatives were irradiated at 354 nm. In contrast, the Z photoisomer of a N‐benzylideneaniline analogue was spectroscopically detected both by absorbance and by 1H NMR spectroscopy.
Predicting the displacement of triple pendulum™ bearings in a full‐scale shaking experiment using a three‐dimensional element
Authors: Dao Nhan D. , Ryan Keri L. , Sato Eiji , Sasaki Tomohiro 
Published: March 2013

SUMMARYThe accuracy of a series spring model to predict the peak displacement and displacement history of Triple Pendulum™ (TP) bearings in a strongly shaken, full‐scale building is evaluated in this paper. The series spring model was implemented as a self‐contained three‐dimensional TP bearing element in OpenSees and is now available for general use. The TP bearing element contains the option for constant friction or a generalized friction model that accounts for the effect of instantaneous velocity and compression load on the friction coefficient. Comparison between numerical simulation and experimental data of a five‐story steel moment frame building shows that the peak displacement of isolation system can generally be predicted with confidence using a constant friction coefficient model. The friction coefficient model accounting for the effect of axial load and velocity leads to minor improvement over the constant friction coefficient models in some cases. Copyright © 2013 John Wiley & Sons, Ltd.
High biolability of ancient permafrost carbon upon thaw
Authors: Vonk Jorien E. , Mann Paul J. , Davydov Sergey , Davydova Anna , Spencer Robert G. M. , Schade John , Sobczak William V. , Zimov Nikita , Zimov Sergei , Bulygina Ekaterina , Eglinton Timothy I. , Holmes Robert M. 
Published: March 2013

AbstractOngoing climate warming in the Arctic will thaw permafrost and remobilize substantial terrestrial organic carbon (OC) pools. Around a quarter of northern permafrost OC resides in Siberian Yedoma deposits, the oldest form of permafrost carbon. However, our understanding of the degradation and fate of this ancient OC in coastal and fluvial environments still remains rudimentary. Here, we show that ancient dissolved OC (DOC, >21,000 14C years), the oldest DOC ever reported, is mobilized in stream waters draining Yedoma outcrops. Furthermore, this DOC is highly biolabile: 34 ± 0.8% was lost during a 14 day incubation under dark, oxygenated conditions at ambient river temperatures. Mixtures of Yedoma stream DOC with mainstem river and ocean waters, mimicking in situ mixing processes, also showed high DOC losses (14 days; 17 ± 0.8% to 33 ± 1.0%). This suggests that this exceptionally old DOC is among the most biolabile DOC in any previously reported contemporary river or stream in the Arctic.
Sorafenib in patients with refractory or recurrent multiple myeloma
Authors: Yordanova Anna , Hose Dirk , Neben Kai , Witzens‐Harig Mathias , Gütgemann Ines , Raab Marc‐Steffen , Moehler Thomas , Goldschmidt Hartmut , Schmidt‐Wolf Ingo GH 
Published: March 2013

AbstractSorafenib is a small molecular inhibitor of several tyrosine protein kinases, including vascular endothelial growth factor receptor, platelet‐derived growth factor receptor and rapidly accelerated fibrosarcoma kinases, targeting signal transduction and angiogenic pathways. It is approved for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma. The objectives of this prospective phase II trial were to assess the activity and tolerability of sorafenib in patients with recurrent or refractory myeloma. In total, 11 patients were enrolled. Patients received 2 × 200 mg of sorafenib orally twice daily until completing 13 full cycles or disease progression. Of the side effects, 8.8% grade 3 and 1.1% grade 4 occurred. Sorafenib treatment was effective in two patients who achieved a partial response and a continuous stable disease with duration of 24.4 months and 6.9 month, respectively. Further clinical investigations are recommended to investigate sorafenib single agent activity in myeloma subgroups with ras‐/BRAF‐/vascular endothelial growth factor receptor pathway activation and combination therapy approaches. Copyright © 2013 John Wiley & Sons, Ltd.