bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategy Training During Inpatient Rehabilitation May Prevent Apathy Symptoms After Acute Stroke
Authors: Skidmore Elizabeth R. , Whyte Ellen M. , Butters Meryl A. , Terhorst Lauren , Reynolds Charles F. 
Published: January 2015

AbstractBackgroundApathy, or lack of motivation for goal‐directed activities, contributes to reduced engagement in and benefit from rehabilitation, impeding recovery from stroke.ObjectiveTo examine the effects of strategy training, a behavioral intervention used to augment usual inpatient rehabilitation, on apathy symptoms over the first 6 months after stroke.DesignSecondary analysis of randomized controlled trial.SettingAcute inpatient rehabilitation.ParticipantsParticipants with acute stroke who exhibited cognitive impairments (Quick Executive Interview Scores ≥3) and were admitted for inpatient rehabilitation were randomized to receive strategy training (n = 15, 1 session per day, 5 days per week, in addition to usual inpatient rehabilitation) or reflective listening (n = 15, same dose).MethodsStrategy training sessions focused on participant‐selected goals and participant‐derived strategies to address these goals, using a global strategy training method (Goal‐Plan‐Do‐Check). Reflective listening sessions focused on participant reflections on their rehabilitation goals and experiences, facilitated by open‐ended questions and active listening skills (attending, following, and responding).Main Outcome MeasuresTrained raters blinded to group assignment administered the Apathy Evaluation Scale at study admission, 3 months, and 6 months. Data were analyzed with repeated‐measures fixed‐effects models.ResultsParticipants in both groups had similar subsyndromal levels of apathy symptoms at study admission (strategy training, mean = 25.79, standard deviation = 7.62; reflective listening, mean = 25.18, standard deviation = 4.40). A significant group × time interaction (F2,28 = 3.61, P = .040) indicated that changes in apathy symptom levels differed between groups over time. The magnitude of group differences in change scores was large (d = −0.99, t28 = −2.64, P = .013) at month 3 and moderate to large (d = −0.70, t28 = −1.86, P = .073) at month 6.ConclusionStrategy training shows promise as an adjunct to usual rehabilitation for maintaining low levels of poststroke apathy.
Personal reputation and the organization
Authors: Zinko Robert , Rubin Mark 
Published: January 2015

AbstractDrawing from fields such as marketing psychology, strategy, social psychology, and organizational behavior, the present examination explores the individual and organizational bases for personal reputation; specifically, how different bases interact with one another to produce an individual’s reputation within organizations. It is proposed that individuals use personal reputations to satisfy their need for positive self-esteem as well as to secure their sense of belonging in organizations. Furthermore, reputation allows individuals to obtain rewards such as autonomy, power, and career success and the opportunity to signal key information to audiences. Likewise, organizations utilize personal reputations to predict their members’ behaviors, market those who are a part of the organization to others, build their own corporate reputations, and signal information to consumers and competitors. To further this understanding of personal reputation an examination is presented as to how organizations serve as an essential context within which individuals realize their personal reputations and regulate their behavior.
NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation
Authors: Lee Hyemi , Oh Eun-Taex , Choi Bo-Hwa , Park Moon-Taek , Lee Ja-Kyeong , Lee Jae-Seon , Park Heon Joo 
Published: January 2015

AbstractOxygen and glucose deprivation (OGD) due to insufficient blood circulation can decrease cancer cell survival and proliferation in solid tumors. OGD increases the intracellular [AMP]/[ATP] ratio, thereby activating the AMPK. In this study, we have investigated the involvement of NQO1 in OGD-mediated AMPK activation and cancer cell death. We found that OGD activates AMPK in an NQO1-dependent manner, suppressing the mTOR/S6K/4E-BP1 pathway, which is known to control cell survival. Thus, the depletion of NQO1 prevents AMPK-induced cancer cell death in OGD. When we blocked OGD-induced Ca2+/CaMKII signaling, the NQO1-induced activation of AMPK was attenuated. In addition, when we blocked the RyR signaling, the accumulation of intracellular Ca2+and subsequent activation of CaMKII/AMPK signaling was decreased in NQO1-expressing cells under OGD. Finally, siRNA-mediated knockdown of CD38 abrogated the OGD-induced activation of Ca2+/CaMKII/AMPK signaling. Taken together, we conclude that NQO1 plays a key role in the AMPK-induced cancer cell death in OGD through the CD38/cADPR/RyR/Ca2+/CaMKII signaling pathway.
Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75)
Authors: Kopanic Jennifer L. , Schlingmann Barbara , Koval Michael , Lau Alan F. , Sorgen Paul L. , Su Vivian F. 
Published: January 2015

The connexin43-interacting protein of 75 kDa directly interacts with the gap junction proteins connexin32, connexin40 and connexin45, facilitating their proteasomal degradation.
Carbapenem Therapy Is Associated With Improved Survival Compared With Piperacillin-Tazobactam for Patients With Extended-Spectrum β-Lactamase Bacteremia
Authors: Tamma Pranita D. , Han Jennifer H. , Rock Clare , Harris Anthony D. , Lautenbach Ebbing , Hsu Alice J. , Avdic Edina , Cosgrove Sara E. 
Published: January 2015

Abstract
Background.  The effectiveness of piperacillin-tazobactam (PTZ) for the treatment of extended-spectrum β-lactamase (ESBL) bacteremia is controversial. We compared 14-day mortality of PTZ vs carbapenems as empiric therapy in a cohort of patients with ESBL bacteremia who all received definitive therapy with a carbapenem.
Methods.  Patients hospitalized between January 2007 and April 2014 with monomicrobial ESBL bacteremia were included. A decrease of &gt;3 doubling dilutions in the minimum inhibitory concentration for third-generation cephalosporins tested in combination with 4 µg/mL of clavulanic acid was used to confirm ESBL status. The primary exposure was empiric therapy, defined as antibiotic therapy administered to a patient before ESBL status was known. Patients were excluded if they did not receive a carbapenem after ESBL production was identified. The primary outcome was time to death from the first day of bacteremia. Propensity scores using inverse probability of exposure weighting (IPW) were used to estimate the probability that a patient would receive PTZ vs carbapenems empirically. We calculated overall hazard ratios for mortality censored at 14 days using Cox proportional hazards models on an IPW-adjusted cohort.
Results.  A total of 331 unique patients with ESBL bacteremia were identified. One hundred three (48%) patients received PTZ empirically and 110 (52%) received carbapenems empirically. The adjusted risk of death was 1.92 times higher for patients receiving empiric PTZ compared with empiric carbapenem therapy (95% confidence interval, 1.07–3.45).
Conclusions.  PTZ appears inferior to carbapenems for the treatment of ESBL bacteremia. For patients at high risk of invasive ESBL infections, early carbapenem therapy should be considered. Our findings should not be extended to β-lactam/β-lactamase inhibitor combinations in development, as limited clinical data are available for these agents.
Hydroxychloroquine reduces risk of incident diabetes mellitus in lupus patients in a dose-dependent manner: a population-based cohort study
Authors: Chen Yi-Ming , Lin Ching-Heng , Lan Tsuo-Hung , Chen Hsin-Hua , Chang Shih-Ni , Chen Yi-Hsing , Wang Jun-Sing , Hung Wei-Ting , Lan Joung-Liang , Chen Der-Yuan 
Published: January 2015

Abstract
Objective. SLE is associated with increased risk of diabetes mellitus. Treatment for SLE requires high-dose glucocorticoids that may worsen glucose homoeostasis. HCQ can reduce diabetes risk in RA. This study aimed to investigate the association of HCQ use and diabetes mellitus risk in SLE patients.
Methods. This nationwide, population-based cohort study was conducted using the Taiwan National Health Insurance Research Database. In the period 2001–10, 8628 newly diagnosed SLE patients were identified after excluding those with a previous diagnosis of RA, psoriasis or diabetes mellitus. Incidence of diabetes mellitus was identified as a new diagnostic code using a diabetes mellitus-specific medication.
Results. Two hundred and twenty-one newly diagnosed diabetes mellitus patients were identified among SLE patients (6795 had taken HCQ and 1833 had never taken HCQ), with an average follow-up period of 5.6 years. Compared with patients without HCQ treatment, the hazard ratio (HR) of diabetes mellitus in patients taking HCQ at a cumulative dose ≥129 g was reduced [HR 0.26 (95% CI 0.18, 0.37), P &lt; 0.001]. Daily glucocorticoid ≥10 mg prednisolone-equivalent dose was associated with increased risk of developing diabetes mellitus [HR 2.47 (95% CI 1.44, 4.23), P = 0.001], which was minimized by concomitant HCQ use at a cumulative dose ≥129 g.
Conclusion. In SLE patients, the use of HCQ is associated with reduced risk of incident diabetes mellitus in a dose-dependent manner. High-dose glucocorticoids increase the risk of diabetes, which can be decreased by concomitant HCQ use.
Global ontology research progress: a bibliometric analysis
Authors: Zhu Qiaoli , Kong Xuesong , Hong Song , Li Junli , He Zongyi 
Published: January 2015

Purpose
– The purpose of this paper is to analyse the global scientific outputs of ontology research, an important emerging discipline that has huge potential to improve information understanding, organization, and management.

Design/methodology/approach
– This study collected literature published during 1900-2012 from the Web of Science database. The bibliometric analysis was performed from authorial, institutional, national, spatiotemporal, and topical aspects. Basic statistical analysis, visualization of geographic distribution, co-word analysis, and a new index were applied to the selected data.

Findings
– Characteristics of publication outputs suggested that ontology research has entered into the soaring stage, along with increased participation and collaboration. The authors identified the leading authors, institutions, nations, and articles in ontology research. Authors were more from North America, Europe, and East Asia. The USA took the lead, while China grew fastest. Four major categories of frequently used keywords were identified: applications in Semantic Web, applications in bioinformatics, philosophy theories, and common supporting technology. Semantic Web research played a core role, and gene ontology study was well-developed. The study focus of ontology has shifted from philosophy to information science.

Originality/value
– This is the first study to quantify global research patterns and trends in ontology, which might provide a potential guide for the future research. The new index provides an alternative way to evaluate the multidisciplinary influence of researchers.
Defining user risk in social networking services
Authors: Haynes David , Robinson Lyn 
Published: January 2015

Purpose– The purpose of this paper is to identify the risks faced by users of online social networking services (SNSs) in the UK and to develop a typology of risk that can be used to assess regulatory effectiveness.Design/methodology/approach– An initial investigation of the literature revealed no detailed taxonomies of risk in this area. Existing taxonomies were reviewed and merged with categories identified in a pilot survey and expanded in purposive sample survey directed at the library and information services (LIS) community in the UK.Findings– Analysis of the relationships between different risk categories yielded a grouping of risks by their consequences. This aligns with one of the objectives of regulation, which is to mitigate risks.Research limitations/implications– This research offers a tool for evaluation of different modes of regulation of social media.Practical implications– Awareness of the risks associated with use of online SNSs and wider social media contributes to the work of LIS professionals in their roles as: educators; intermediaries; and users of social media. An understanding of risk also informs the work of policy makers and legislators responsible for regulating access to personal data.Originality/value– A risk-based view of regulation of personal data on social media has not been attempted in such a comprehensive way before.
Perception of bank employees’ towards working environment of selected Indian universal banks
Authors: Kaur Gagandeep 
Published: January 2015

Purpose
– The purpose of this paper is to evaluate the job satisfaction level of universal bank employees in India. It focusses on identifying the factors of job satisfaction and their influence on the overall job satisfaction of universal bank employees.

Design/methodology/approach
– Data were collected from a sample of 380 bank employees using convenience sampling technique.

Findings
– The results of exploratory factor analysis reveal that eight factors, i.e. workplace environment, supervision, cooperation from peers, work discrimination, employee acceptance, work allocation, job security and remuneration extracted as important determinants of job satisfaction. The results of multiple regression analysis shows that supervision, cooperation from peers, work allocation and employee acceptance (independent variables) influences the level of job satisfaction (dependent variable of bank employees.

Originality/value
– Since liberalization, banking sector is considered to be one of the major recruiters. People prefer bank as a career and social status. In order to further improve the satisfaction level of bank employees, bank management should provide regular feedback to the employees about their performance. In the absence of feedback, employees will be discouraged because they do not know how they are doing or may believe their contribution is unacknowledged. The most important factor effecting employee satisfaction with their job is their immediate supervisor. Many employees dislike their supervisor though they like the work they do. To make employees happier in their position, stay longer and the most important to ensure that customers receive better services, banks must start improving the management skills of supervisors.
Improving university facilities services using Lean Six Sigma: a case study
Authors: Isa Mohsen F. Mohamed , Usmen Mumtaz 
Published: January 2015

Purpose
– The purpose of this paper is to present a case study on the use of Lean Six Sigma principles and tools to study the improvement in design and construction services at a university. The quality of facilities services at universities has been criticized by users calling for improvement.

Design/methodology/approach
– Quality of facilities services at universities has been criticized by users calling for improvement. The purpose of this paper is to present a case study on using Lean Six Sigma principles and tools to study improving design and construction services at a university.

Findings
– It was found that non-value-added general improvement review form (GIRF) process steps involving revisions and rework for the design and construction result in time delays, cost increases and quality deficiencies and render cost estimates unreliable; these are unnecessary and should be minimized or eliminated. It was additionally noted that administrative reviews and approvals embedded in GIRF processes slow down work flow, leading to similar problems. Because such steps may be needed for institutional reasons precluding elimination, it was recommended that efforts be directed toward reducing their durations and costs. Overall, the Lean Six Sigma methodology proved to be successful for the intended purpose.

Originality/value
– Although universities are aware of their facilities services’ quality issues and have been addressing them, no published information is available on how to systematically evaluate and improve such services to increase customer satisfaction. This paper aims at filling this gap.
Lean implementation in Indian process industries – some empirical evidence
Authors: Panwar Avinash , Jain Rakesh , Rathore A.P.S. 
Published: January 2015

Purpose
– In the present era of intense competition, industries are adopting lean manufacturing for successful survival. The concept of lean manufacturing is new for Indian process industries. The purpose of this paper is to investigate the status of lean manufacturing in Indian process industries in terms of lean practices, reasons and challenges of implementing lean manufacturing.

Design/methodology/approach
– A survey was carried out to assess the level of lean implementation in Indian process industries. Statistical tests were conducted to assess the significant lean practices, reasons and challenges of implementing lean in Indian process industries.

Findings
– It is observed that the level of implementation of lean manufacturing in Indian process industries is still low. Results indicate that Indian process industries those who have implemented lean found lean to be very useful to reduce wastes and to increase quality. Major lean practices being implemented by Indian process industries are primarily those which are related to waste elimination or improvement in quality. Indian process industries found that important challenges to implement lean are to produce in small batches, to arrange for lean experts and to impart training to employees.

Research limitations/implications
– In the present study, the sample size is small and hence, the findings should be generalized cautiously. Although the study indicates that lean can be very useful if implemented in Indian process industries but further empirical studies are required to quantify performance improvements through adoption of lean.

Originality/value
– The paper explores status of lean adoption in Indian process industries. Considering the unique characteristics of process industries, the present research would be helpful for making strategies to implement lean in process industry setups.
Moose browsing alters tree diversity effects on birch growth and insect herbivory
Authors: Muiruri Evalyne W. , Milligan Harriet T. , Morath Simon , Koricheva Julia 
Published: January 2015

Summary

Producer diversity is known to affect a wide range of ecosystem processes including plant growth and insect pest resistance. Consumers such as mammalian herbivores too have been shown to modify plant growth and insect herbivory by triggering changes in host plants. However, few studies have investigated whether consumer effects interact with plant species diversity effects on a focal plant.

To unravel consumer‐diversity interactions, we recorded both the presence and intensity of winter browsing by moose (Alces alces) on silver birch (Betula pendula) in a long‐term forest diversity experiment in Finland and measured birch tree growth as well as insect chewing damage during the following growing season.

Although browsing on birch by moose was not affected by tree species richness, the intensity of moose damage altered tree diversity effects on birch tree growth. At minor browsing intensity, tree height, trunk diameter and canopy projections showed positively humped relationships with tree diversity, peaking at 3‐species mixtures. Growth of moderately browsed trees increased with tree species richness, but growth of severely browsed birch trees was unaffected.

Moose browsing also altered the direction of tree diversity effects on insect herbivory on birch. Unbrowsed trees experienced lower insect chewing damage in mixed stands (associational resistance) whilst browsed trees suffered more insect chewing damage in diverse stands (associational susceptibility). Increasing browsing intensity also reversed the relationship between tree species richness and insect chewing damage from negative to positive.

The observed interactions between moose browsing and tree species richness effects could be explained by lower canopy cover of more diverse stands compared with birch monocultures, leading to increased re‐growth capacity and more high‐quality foliage of browsed birch trees in more open diverse stands.

Our findings demonstrate that both the presence and intensity of mammalian browsing may modify the magnitude and even the direction of tree diversity effects on tree growth and susceptibility to insect herbivory. Differences in consumer impact among studies may thus potentially explain much of the observed variability in plant diversity effects on ecosystem functioning and must therefore be taken into account in future studies.
Effect of the number of presentations on listener transcriptions and reliability in the assessment of speech intelligibility in children
Authors: Lagerberg Tove B. , Johnels Jakob Åsberg , Hartelius Lena , Persson Christina 
Published: January 2015

AbstractBackgroundThe assessment of intelligibility is an essential part of establishing the severity of a speech disorder. The intelligibility of a speaker is affected by a number of different variables relating, inter alia, to the speech material, the listener and the listener task.AimsTo explore the impact of the number of presentations of the utterances on assessments of intelligibility based on orthographic transcription of spontaneous speech, specifically the impact on intelligibility scores, reliability and intra‐listener variability.Methods & ProceduresSpeech from 12 children (aged 4:6–8:3 years; mean = 5:10 years) with percentage consonants correct (PCC) scores ranging from 49 to 81 was listened to by 18 students on the speech–language pathology (SLP) programme and by two recent graduates from that programme. Three conditions were examined during the transcription phase: (1) listening to each utterance once; (2) listening to each utterance a second time; and (3) listening to all utterances from a given child a third time after having heard all of its utterances twice.Outcomes & ResultsStatistically significant differences between intelligibility scores were found across the three conditions, i.e. the intelligibility score increased with the number of presentations while inter‐judge reliability was unchanged. The results differed markedly across listeners, but each individual listener's results were very consistent across conditions.Conclusions & ImplicationsInformation about the number of times an utterance is presented to the listener is important and should therefore always be included in reports of research involving intelligibility assessment. There is a need for further research and discussion on listener abilities and strategies.
Dietary patterns and body mass indices among adults in Korea: evidence from pseudo panel data
Authors: Kwock Chang Keun , Park Junhyung 
Published: January 2015

AbstractThe debate over the association between dietary patterns and obesity has not been settled in the literature. Some studies suggest that there are significant differences in mean body mass index across dietary patterns whereas other studies refute that result. The objective of this study is to test whether dietary patterns have a significant effect on body mass index in Korean adults when controlling for calorie intake and several sociodemographic factors. We present new evidence derived from pseudo panel data created from a series of cross‐sections. Our results from the pseudo panel analysis show that some of the dietary patterns that were identified from the Korean adults’ food intake survey have a significant effect on body mass index. Specifically, males with the “beef and processed food” (P < 0.05), or “pork and alcohol” (P < 0.05) dietary pattern had significantly higher BMIs, whereas females with the “fast food” (P < 0.1) or “ramen and bakery” (P < 0.01) dietary pattern had higher BMI.