bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Factors Predictive of Efficacy Among Patients With Complicated Urinary Tract Infection and/or Acute Pyelonephritis
Authors: Bhavnani Sujata M , Hammel Jeffrey P , Rubino Christopher M , Talley Angela K , Eckburg Paul B , Liolios Kathryn , Gupta Vipul K , Ambrose Paul G , Hamed Kamal A , Melnick David A 
Published: July 2024

AbstractBackgroundAntibiotic treatment for complicated urinary tract infections (cUTI)/acute pyelonephritis (AP) is often followed by recurrent bacteriuria in the absence of clinical symptoms. To understand factors predictive of clinical and microbiologic outcomes in patients with cUTI/AP, multivariable analyses were undertaken using pooled data from a global, phase 3 cUTI study.MethodsUsing data from 366 tebipenem pivoxil hydrobromide– and 378 ertapenem-treated patients from the Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) infected with Enterobacterales uropathogens, multivariable analyses for dichotomous efficacy endpoints were performed using logistic regression and pharmacokinetic-pharmacodynamic relationships were evaluated.ResultsUrinary tract anatomical disorders and functional urinary tract or metabolic disorders were predictive of nonresponse across all efficacy endpoints assessed at test-of-cure (TOC) and late follow-up (LFU) visits, with greater impact on overall and microbiologic than clinical nonresponse. Independent variables predictive of increased probabilities of successful overall response at TOC and microbiologic response at TOC or LFU were baseline creatinine clearance &gt;50 mL/min and baseline pathogen fluoroquinolone susceptibility. Infection with a phenotypic extended-spectrum beta-lactamase–positive Enterobacterales pathogen was predictive of reduced probabilities of success for microbiologic response at LFU and clinical response at TOC. Meaningful relationships between efficacy endpoints and plasma pharmacokinetic-pharmacodynamic indices were not identified.ConclusionsReductions of overall and microbiologic response in patients with cUTI/AP were associated with anatomical or functional urinary tract disorders, but not with the magnitude or duration of plasma antibiotic exposure. Results of these analyses serve to advance our understanding of factors predictive of outcome in patients with cUTI/AP.
Global Epidemiology and Seasonality of Human Seasonal Coronaviruses: A Systematic Review
Authors: Wilson Rory , Kovacs Dory , Crosby Mairi , Ho Antonia 
Published: July 2024

Abstract

Background
We characterized the global epidemiology and seasonality of human coronaviruses (HCoVs) OC43, NL63, 229E, and HKU1.

Methods
In this systematic review, we searched MEDLINE, EMBASE, Web of Science, SCOPUS, CINAHL, and backward citations for studies published until 1 September 2023. We included studies with ≥12 months of consecutive data and tested for ≥1 HCoV species. Case reports, review articles, animal studies, studies focusing on SARS-CoV-1, SARS-CoV-2, and/or Middle East respiratory syndrome, and those including &lt;100 cases were excluded. Study quality and risk of bias were assessed using Joanna Briggs Institute Critical Appraisal Checklist tools. We reported the prevalence of all HCoVs and individual species. Seasonality was reported for studies that included ≥100 HCoVs annually. This study is registered with PROSPERO, CRD42022330902.

Results
A total of 201 studies (1 819 320 samples) from 68 countries were included. A high proportion were from China (19.4%; n = 39), whereas the Southern Hemisphere was underrepresented. Most were case series (77.1%, n = 155) with samples from secondary care (74.1%, n = 149). Seventeen (8.5%) studies included asymptomatic controls, whereas 76 (37.8%) reported results for all 4 HCoV species. Overall, OC43 was the most prevalent HCoV. Median test positivity of OC43 and NL63 was higher in children, and 229E and HKU1 in adults. Among 18 studies that described seasonality (17 from the Northern Hemisphere), circulation of all HCoVs mostly peaked during cold months.

Conclusions
In our comprehensive review, few studies reported the prevalence of individual HCoVs or seasonality. Further research on the burden and circulation of HCoVs is needed, particularly from Africa, South Asia, and Central/South America.
From Transmitting Authority to Quiet Adaptation: Social Change and the Translation of Islamic Knowledge in Norway
Authors: Elgvin Olav 
Published: July 2024

Abstract
This article explores the transmission of textual Islamic knowledge in Norway—a context in which Muslims form a religious minority—using a pioneering method: studying the translation of texts. Many Muslims in Norway either came from another country themselves or have progenitors who did. Important texts relating to Islam have mostly been available in languages other than Norwegian. This makes it possible to use translation as a lens for understanding how Islamic knowledge is transmitted. I identify two tendencies in the transmission of Islamic knowledge through translation. Translation often cements the status of established and canonized texts and authors. But translation activities also show an adaptation to norms in Norwegian society. Texts pertaining to politically charged issues have sometimes been avoided altogether, and the wording of charged sections has in some instances been subtly changed. I label this process quiet adaptation. Many of the translated texts espouse a normativity that is more palatable to Norwegian society at large, and which Muslims living in Norway can more easily identify with. I conclude by discussing how the study of translation can be used as a way to explore social change in Muslim and other diaspora groups in Europe.
In Situ Lu–Hf Garnet Dating of Archean Deep Crust Granulites from the Polymetamorphic Grenville Front Tectonic Zone
Authors: Godet Antoine , Jouvent Marine , Laureijs Christiaan , Guilmette Carl , Larson Kyle , Coleman Mark , Darveau Jérémie , Côté-Roberge Myriam 
Published: July 2024

Abstract
Recent advances in geochronological techniques now make it possible to efficiently decipher the timing and duration of geological processes in complex high-grade polymetamorphosed orogenic terranes. This is the case of the Grenville Front Tectonic Zone, which truncates the Superior Craton to the southeast. The zone exposes parautochthonous Archean rocks that underwent mid- to high-pressure granulite facies metamorphism of uncertain age. The metamorphic assemblages have been either interpreted as Archean and associated with the final stages of the Superior Craton assembly or as the result of Mesoproterozoic Grenvillian metamorphism, based on cross-cutting relationships and traditional geochronology methods such as U–Pb zircon and 40Ar–39Ar mica dating. Herein, we revisit the extent of the Grenvillian metamorphic overprint in the parautochthonous domain and provide new age constraints for granulite-facies metamorphic assemblages through in situ garnet dating within migmatitic paragneiss, migmatitic orthogneiss, and mafic granulites, combined with in situ trace element mapping. Six samples, which show bell-shaped and occasionally sharp and oscillatory lutetium growth zoning in garnet, yield garnet Lu–Hf isochrons with identical Archean dates of c. 2.6 Ga. Sparse analyses of the material trend towards Grenvillian ages (c. 1 Ga) in one sample from which garnet shows lutetium zoning consistent with post-growth fluid-assisted disturbance. Overall, our results indicate that the widespread granulite-facies metamorphism within the Grenville Front Tectonic Zone is dominantly late Neoarchean in age, unveiling a rare exposure of Archean lower crust in the southeastern Superior Craton. Our results also point towards a limited Grenvillian metamorphic overprint, though the spatial extent and precise thermal conditions of this metamorphism are still unknown. The results presented herein demonstrate the potential of in situ isotopic geochronology on rock-forming minerals like garnet in polymetamorphic terranes.
Love and unselfing
Authors: Wong Katie H C 
Published: July 2024

Abstract
This paper examines an overlooked aspect of interpersonal love: Like morality, love demands a certain kind of impartial or disinterested vision from us. We cannot love another person well, I argue, without being capable of such impartiality. Unfortunately, our self-interested nature makes meeting love's demand for impartiality extremely difficult if not impossible. This paper unpacks and offers a solution to this difficulty. Drawing on Iris Murdoch's work on love, I suggest that we can come to appreciate our beloveds as we should through unselfing, a state of self-forgetful, disinterested appreciation of an object outside the self. When we unself, we are so deeply moved by an external object's value—e.g. a stunning sunset—that all our subjective cares and concerns disappear from view. In concluding, I suggest that the capacity for impartiality we must develop to love someone well is relevant to understanding what our moral relations demand of us.
Market Power and Price Informativeness
Authors: Kacperczyk Marcin , Nosal Jaromir , Sundaresan Savitar 
Published: July 2024

Abstract
We study the distributional effects of asset ownership on price informativeness in a general equilibrium model. The model features investors (oligopolists) with different degrees of price impact and abilities to learn about individual asset payoffs from private and price signals, and a competitive fringe that only learns from asset prices. We show that price informativeness is non-monotonic in the oligopolists’ aggregate size, decreasing in the sector’s concentration and in the size of the passive sector. We further show that the size effect can be decomposed into a learning channel capturing investors’ quality of private signals and an information pass-through channel measuring the sensitivity of investors’ trades to private signals, with the latter one being the primary source of variation in price informativeness relative to the size distribution.
HLA-B5 prevalence in patients with spondyloarthritis and impact on disease phenotype: a multicentric case–control study
Authors: Ziade Nelly , Bou Jaoude Sarah , Nacouzi Rhéa , Mroue Kamel , Merheb Georges , Klayme Samira , Ghorra Pierre 
Published: July 2024

Abstract

Objective
The study aimed to estimate the prevalence of HLA-B51 and HLA-B52 in Lebanese patients with spondyloarthritis (SpA) compared with healthy controls (HC). We further aimed to evaluate the impact of HLA-B51 on phenotype and identify the distribution of the alleles in the HLA-B locus.

Methods
A case–control study enrolled consecutive SpA patients from three rheumatology clinics in Lebanon, including axial (axSpA), peripheral SpA (pSpA), and psoriatic arthritis (PsA) and HCs from blood donors. Demographic and disease data were collected through interviews and file reviews, with testing of the entire HLA-B locus using molecular techniques. The prevalence of HLA-B51 and B52 was estimated in SpA patients vs controls. Prevalence comparisons were made, and logistic regression identified factors associated with HLA-B51 in patients.

Results
Data from 120 HCs and 86 SpA patients (65 axSpA, 15 pSpA, 6 PsA), mean age 25.6 and 46.4 years, respectively, showed a higher HLA-B51 prevalence in SpA (25.6%), especially axSpA (29.2%) vs HC (12.5%) (P = 0.016), and a numerically higher HLA-B52 prevalence (8.1% vs 4.2%, P = 0.230). HLA-B51 correlated with recurrent oral ulcerations (OR 7.99; 95% CI: 2.14, 29.84) and radiographic juxta-articular erosions (OR 7.65; 95% CI: 1.14, 38.03). HLA-B35 was the most dominant allele in both groups (18.7%), followed by HLA-B27 (15.7%) and HLA-B51 (13.4%) in SpA.

Conclusion
HLA-B51 was identified more frequently in patients with SpA compared with HC and was associated with recurrent oral ulcerations and juxta-articular radiographic erosions. Longitudinal studies are needed to determine whether this association indicates a disease overlap or might correlate with a specific SpA phenotype.
The taxonomic status ofArtemia monicaVerrill, 1869 (Crustacea: Anostraca)
Authors: Asem Alireza , Gajardo Gonzalo , Rogers D Christopher , Sorgeloos Patrick 
Published: July 2024

AbstractSpecies are fundamental units of nature that need proper identification in order to assess and conserve biodiversity. Artemia is a model crustacean for population analysis and comparison in regionally endemic sexual species and parthenogenetic lineages distributed in hypersaline lakes, lagoons, and solar saltworks scattered in arid and semi-arid areas worldwide. The taxonomy of two American Artemia species has been controversial: Artemia monicaVerrill, 1869, adapted to the carbonate-rich conditions of Mono Lake (CA, USA), and Artemia franciscanaKellogg, 1906, a species broadly distributed in the Americas. The former species has been studied little, despite being listed as threatened in the IUCN Red List. In contrast, the latter has been studied extensively, is broadly distributed in the Americas, and has become established as a non-native invasive species in Europe, Asia, Africa, and Australia. Given the need to conserve A. monica, the intraspecific diversity of invasive A. franciscana, and the local species in areas invaded by this species, we reconsider their biodiversity and taxonomic status currently threatened by synonymization. In conclusion, A. monica and A. franciscana should be treated as two separate species that are isolated both ecologically and reproductively.
Impact of Vineyard Fallow Practices on Reducing Meloidogyne hapla Population Densities
Authors: Gagnier Bernadette K. , Zasada Inga A. , Moyer Michelle M. 
Published: July 2024

The northern root-knot nematode ( Meloidogyne hapla) is a common plant-parasitic nematode in northern grape production regions. This nematode induces small galls on roots, which restrict water and nutrient uptake, resulting in poor vine establishment or exacerbated decline in stressed vines. A study was conducted to explore the impacts of site management practices on M. hapla population densities following removal of wine grape ( Vitis vinifera) vineyards in Washington state. Soil was collected from 38 fields, M. hapla second-stage juvenile densities in soil were determined, and, to assist in identifying M. hapla in potentially low-population density samples, an 8-week-long tomato ( Solanum lycopersicum) bioassay was conducted. Vineyard managers also provided information on site management techniques. Of the 20 management techniques and combinations explored (e.g., fallow duration, cover crops, mowing, irrigation, and herbicide applications), only one component resulted in lower M. hapla population densities: duration of the vine-free period. A duration of at least 1 year after vineyard removal showed a decline in M. hapla population densities in the sampled former vineyard sites. These results suggest that a fallow period could be useful as a nonchemical management tool for M. hapla in vineyard replant soils. However, consideration of additional site management factors such as weed management, soil series and amendments, interim crop planting, and irrigation or accumulated rainfall that may support M. hapla development is necessary. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Neurologic disease in the obstetric patient
Authors: Inozemtsev Konstantin , Yeh Evelyn , Nasr Ned F. 
Published: July 2024

Purpose of review
Neurologic disorders and complications during pregnancy are common, but guidelines and data are sparse. This review aims to give an overview of recent developments in neuroanesthesia and management of neuropathology during pregnancy, with the hope that these may fill the gaps in current guidelines and recommendations, as well as their implications for an anesthetic approach.

Recent findings
Neuraxial and general anesthesia are safe in multiple sclerosis and myasthenia gravis, though neuromuscular blockade response is unpredictable and risk for exacerbation exists. Cerebral vascular pathology is common and carries a significant morbidity and mortality burden, but thrombolytic and endovascular therapies are often appropriate and safe. Instrumental vaginal delivery can minimize intracranial pressure shifts and is a viable option. Tumors and cerebral malformations require a complex multidisciplinary and anesthetic approach.

Summary
While clinical trials remain sparse, larger population-based studies offer insight into the optimal approach to the parturient with neurologic disease.
Update on the anesthesia management in adult patients with moyamoya disease
Authors: Yang Kevin J. , Mistry Porus , Ayrian Eugenia 
Published: July 2024

Purpose of review
The anesthetic management of patients with Moyamoya disease (MMD) is challenging and continues to evolve. The goal of this review is to provide updated recommendations on the anesthetic management of adult MMD patients based on the relevant existing literature.

Recent findings
Key findings include the importance of aggressive hydration preoperatively to sustain cerebral perfusion. Hypertension induced intraoperatively may prevent cerebral hypoperfusion. Vigilance against cerebral hyperperfusion after revascularization is necessary, with specific blood pressure targets recommended. Fluid management should aim for normovolemia to mild hypervolemia. Maintaining body temperature helps prevent cerebral vasospasm induced by hypothermia. Maintaining adequate oxygen supply during surgery is crucial. In cases of ischemic stroke, managing hematocrit and oxygen carrying capacity is essential to prevent further ischemia. Extubation decisions should consider baseline neurological function, while postoperative normocapnia helps prevent cerebral hyperperfusion and hypertension. In intensive care, cautious blood pressure management is crucial to prevent secondary complications.

Summary
Strategies in the preoperative, intraoperative, and postoperative anesthetic management of MMD patients should aim to maintain adequate cerebral perfusion to prevent cerebral ischemia.
RANO 2.0 criteria: concepts applicable to the neuroradiologist's clinical practice
Authors: Sanvito Francesco , Castellano Antonella , Cloughesy Timothy F. , Wen Patrick Y. , Ellingson Benjamin M. 
Published: July 2024

Purpose of review
The Response Assessment in Neuro-Oncology (RANO) 2.0 criteria aim at improving the standardization and reliability of treatment response assessment in clinical trials studying central nervous system (CNS) gliomas. This review presents the evidence supporting RANO 2.0 updates and discusses which concepts can be applicable to the clinical practice, particularly in the clinical radiographic reads.

Recent findings
Updates in RANO 2.0 were supported by recent retrospective analyses of multicenter data from recent clinical trials. As proposed in RANO 2.0, in tumors receiving radiation therapy, the post-RT MRI scan should be used as a reference baseline for the following scans, as opposed to the pre-RT scan, and radiographic findings suggesting progression within three months after radiation therapy completion should be verified with confirmatory scans. Volumetric assessments should be considered, when available, especially for low-grade gliomas, and the evaluation of nonenhancing disease should have a marginal role in glioblastoma. However, the radiographic reads in the clinical setting also benefit from aspects that lie outside RANO 2.0 criteria, such as qualitative evaluations, patient-specific clinical considerations, and advanced imaging.

Summary
While RANO 2.0 criteria are meant for the standardization of the response assessment in clinical trials, some concepts have the potential to improve patients’ management in the clinical practice.
Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents
Authors: Friedman Alexa , Schildroth Samantha , Fruh Victoria , Krengel Maxine H. , Tripodis Yorghos , Placidi Donatella , White Roberta F. , Lucchini Roberto G. , Smith Donald R. , Wright Robert O. , Horton Megan K. , Claus Henn Birgit 
Published: July 2024

Background:
Motor function is critical for children’s health, yet remains an understudied neurodevelopmental domain. Exposure to metals has been linked with motor function, but no study has examined the joint effects of metal mixtures.

Methods:
We evaluated cross-sectional associations between a metal mixture and motor function among 569 adolescents (10–14 years old) living near the ferroalloy industry. Concentrations of blood lead, hair manganese, hair copper, and hair chromium were quantified using inductively coupled plasma mass spectrometry. Neuropsychologists administered multiple fine motor function assessments: pursuit aiming, finger tapping, visual reaction time (VRT), and subtests from the Luria Nebraska battery. We estimated associations between motor function and the metal mixture using quantile-based g-computation and multivariable linear regression, adjusting for child age, sex, and socioeconomic status. We explored sex-specific associations in stratified models.

Results:
Associations between the metal mixture and motor function were mostly null but were modified by sex. We observed a beneficial association among females: a quartile increase in all metals in the mixture was associated with a 2.6% faster average response time on the VRT (95% confidence interval [CI] = −4.7%, −0.5%), driven by Cu and Cr. In contrast, this association was adverse among males (ß = 1.5% slower response time [95% CI = −0.7%, 3.9%]), driven by Cu and Mn.

Conclusions:
Results suggest that males may be more susceptible to the adverse effects of metal exposure on motor function during adolescence than females. Future studies, particularly prospective study designs, are warranted to further understand the associations of metal mixtures with motor function.
Lateral Globe Exposure Associated With Graves Upper Eyelid Retraction: The Influence of the Superior Complex Enlargement and Proptosis
Authors: Guimarães Juliana , Garcia Denny M. , Cruz Antonio Augusto V. 
Published: July 2024

Purpose:
To investigate the association of the lateral exposure of the globe with proptosis and the enlargement of the superior complex (SC) (levator palpebrae superioris muscle + superior rectus muscle) in patients with Graves upper eyelid retraction.

Methods:
Twenty-eight patients with upper lid retraction secondary to Graves orbitopathy and 28 controls matched by age and gender participated in the study. The variables exophthalmometry, margin-reflex distance 1, and upper lid fissure temporal and nasal areas were assessed. Coronal CT scans were evaluated for the measurement of the SC area. A 5% level of significance was assumed for analysis.

Results:
Abnormal temporal nasal area differences (T–N), defined as values above the superior limit of the control distribution (15.58 mm2) were detected in 18 patients. Multiple regression analysis showed a significant correlation of abnormal temporo-nasal asymmetries with the SC area and the proptosis (T–N = −6.7 + 0.62* proptosis + 12.3 SC area, R
2 = 0.37; p = 0.003).

Conclusion:
The etiology of the enhanced lateral globe exposure is not unifactorial. SC enlargement and, to a lesser extent, proptosis are important factors correlated to lateral globe exposure.