bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment
Authors: Zhang Fusheng , Guo Junchen , Yu Shengmiao , Zheng Youwei , Duan Meiqi , Zhao Liang , Wang Yihan , Yang Zhi , Jiang Xiaofeng 
Published: July 2024

AbstractThe intrinsic oncogenic mechanisms and properties of the tumor microenvironment (TME) have been extensively investigated. Primary features of the TME include metabolic reprogramming, hypoxia, chronic inflammation, and tumor immunosuppression. Previous studies suggest that senescence‐associated secretory phenotypes that mediate intercellular information exchange play a role in the dynamic evolution of the TME. Specifically, hypoxic adaptation, metabolic dysregulation, and phenotypic shifts in immune cells regulated by cellular senescence synergistically contribute to the development of an immunosuppressive microenvironment and chronic inflammation, thereby promoting the progression of tumor events. This review provides a comprehensive summary of the processes by which cellular senescence regulates the dynamic evolution of the tumor‐adapted TME, with focus on the complex mechanisms underlying the relationship between senescence and changes in the biological functions of tumor cells. The available findings suggest that components of the TME collectively contribute to the progression of tumor events. The potential applications and challenges of targeted cellular senescence‐based and combination therapies in clinical settings are further discussed within the context of advancing cellular senescence‐related research.
Incorporating verbal and nonverbal aspects to enhance a model of patient communication in cancer care: A grounded theory study
Authors: Guetterman Timothy C. , Sakakibara Rae , Baireddy Srikar , Babchuk Wayne A. 
Published: July 2024

AbstractPurposeHigh‐quality communication is essential to patient‐centered care. Existing communication models and research tends to focus on what is said verbally with little attention to nonverbal aspects of communication. In sensitive and emotionally intensive healthcare encounters, such as in cancer care, provider and patient nonverbal behavior may be particularly important for communicating with empathy. Therefore, the aim of this study was to develop a conceptual model of communication that accounts for nonverbal behavior.MethodsWe followed a systematic grounded theory design that involved semi‐structured interviews with 23 providers, including nurse practitioners, physicians, surgeons, and physician's assistants. Using constant comparative analysis, we analyzed transcripts and developed a grounded theory model of communication accounting for nonverbal behavior.ResultsThe major themes included building rapport, gauging how patients will take bad news, ensuring patients' understanding of their conditions, staying honest but hopeful, centering but guiding patient through cancer care, conveying empathy while managing heightened emotions, and ensuring patient understanding. Throughout the process, providers synthesize both verbal and nonverbal information and apply what they learn to future encounters.ConclusionsThe results extend existing models of patient‐centered communication and invite communication intervention and research that incorporates nonverbal behavior. The model contributes an understanding of the full process of communication in clinical encounters.
Establishment of an animal model of immune‐related adverse events induced by immune checkpoint inhibitors
Authors: Meng Yuan , Lv Yingge , Shen Meng , Yu Wenwen , Liu Yumeng , Liu Ting , Liu Gen , Ma Shiya , Hui Zhenzhen , Ren Xiubao , Liu Liang 
Published: July 2024

AbstractObjectiveImmunotherapy, specifically immune checkpoint inhibitors (ICIs), has revolutionized cancer treatment. However, it can also cause immune‐related adverse events (irAEs). This study aimed to develop a clinically practical animal model of irAEs using BALB/c mice.MethodsSubcutaneous tumors of mouse breast cancer 4T1 cells were generated in inbred BALB/c mice. The mice were treated with programmed death‐1 (PD‐1) and cytotoxic t‐lymphocyte antigen 4 (CTLA‐4) inhibitors once every 3 days for five consecutive administration cycles. Changes in tumor volume and body weight were recorded. Lung computed tomography (CT) scans were conducted. The liver, lungs, heart, and colon tissues of the mice were stained with hematoxylin–eosin (H&E) staining to observe inflammatory infiltration and were scored. Serum samples were collected, and enzyme‐linked immunosorbent assay (ELISA) was used to detect the levels of ferritin, glutamic‐pyruvic transaminase (ALT), tumor necrosis factor‐α (TNF‐α), interferon‐gamma (IFN‐γ), and interleukin‐6 (IL‐6). Mouse liver and lung cell suspensions were prepared, and changes in macrophages, T cells, myeloid‐derived suppressor cells (MDSCs), and regulatory (Treg) cells were detected by flow cytometry.ResultsMice treated with PD‐1 and CTLA‐4 inhibitors showed significant reductions in tumor volume and body weight. The tissue inflammatory scores in the experimental group were significantly higher than those in the control group. Lung CT scans of mice in the experimental group showed obvious inflammatory spots. Serum levels of ferritin, IL‐6, TNF‐α, IFN‐γ, and ALT were significantly elevated in the experimental group. Flow cytometry analysis revealed a substantial increase in CD3+T cells, Treg cells, and macrophages in the liver and lung tissues of mice in the experimental group compared with the control group, and the change trend of MDSCs was opposite.ConclusionsThe irAE‐related animal model was successfully established in BALB/c mice using a combination of PD‐1 and CTLA‐4 inhibitors through multiple administrations with clinical translational value and practical. This model offers valuable insights into irAE mechanisms for further investigation.
The impact of immersive and flow experiences on consumer participation in hyper‐connected shopping platforms: A metaverse perspective
Authors: Zhong Zeling , Hamouda Manel 
Published: July 2024

AbstractConsumers find it increasingly compelling to immerse themselves in the metaverse, a trend that will likely continue. Although the metaverse has retailing potential, understanding empirically its effects on consumer behavior is still underexplored. Our study investigating consumer interactions in this hyper‐connected shopping environment uses scenario‐based data from 262 consumers and a multimethod quantitative approach to examine the integrative behavioral model, revealing consumer perceptions of metaverse affordances, their impact on self‐efficacy, and the role of trust, immersion, and flow experiences in participation in metaverse shopping platforms. Perceived enjoyment emerges as a critical driver of consumer participation. This study provides convincing empirical evidence of the drivers specific to consumer metaverse experiences, going beyond the current understanding of consumer behavior in the metaverse shopping context, mainly at the conceptual level. The findings provide actionable insights for metaverse practitioners to enhance consumer engagement.
Chemical Diversity, Pharmacology, Synthesis and Detection of Naturally Occurring Peroxides
Authors: Eka Ningrum Nindya , Cahyaning Rahamjnhyu Dyah Utami , Dianhar Hanhan , Wongso Hendris , Keller Paul A. , Satia Nugraha Ari 
Published: July 2024

AbstractNatural occurring peroxides are interesting bioprospecting targets due to their molecular structural diversity and the wide range of pharmacological activities. In this systematic review, a total of 123 peroxide compounds were analysed from 99 published papers with the compounds distributed in 31 plants, 18 animals and 41 microorganisms living in land and water ecosystems. The peroxide moiety exists as both cyclic and acyclic entities and can include 1,2‐dioxolanes, 1,2‐dioxane rings and common secondary metabolites with a peroxo group. These peroxides possessed diverse bioactivities including anticancer, antimalarial, antimicrobial, anti‐inflammatory, neuroprotective, adipogenic suppressor, antituberculosis, anti‐melanogenic and anti‐coagulant agents. Biosynthetic pathways and mechanisms of most endoperoxides have not been well established. Method development in peroxide detection has been a challenging task requiring multidisciplinary investigation and exploration on peroxy‐containing secondary metabolites are necessary.
Exploring the Antioxidant and Anti‐Inflammatory Effects of Rhoifolin Isolated from Teucrium Polium on Rats’ Lungs Exposed to Tobacco Smoke
Authors: Al‐Shalabi Eveen , Sunoqrot Suhair , Al‐Zuhd Thanaa , Alshehada Rahaf S. , Ibrahim Ali I. M. , Hammad Alaa M. 
Published: July 2024

AbstractCigarette smoking exacerbates respiratory diseases, while plant‐derived polyphenols offer antioxidant and anti‐inflammatory benefits. This study exploresd the effects of Rhoifolin (ROF), a polyphenol from Jordanian Teucrium polium, on lung health in rats exposed to tobacco smoke. Male rats were divided into two groups: one exposed to cigarette smoke (CS), and the other to ROF treatment alongside smoke exposure (CS/ROF). ROF was administered orally for 21 days before smoke exposure. Results showed smoke‐induced lung inflammation and oxidative stress, mitigated by ROF treatment. Histological examination revealed smoke‐related morphological changes in lung tissue. ROF treatment reduced oxidative stress and inflammation, as evidenced by decreased proinflammatory cytokines. In silico docking demonstrated ROF's potential as an inhibitor of proinflammatory cytokines. This study demonstrates the therapeutic potential of ROF and similar polyphenols in mitigating the harmful effects of cigarette smoke on lung health.
Synthesis of Para‐Acetylated Functionalized Ni(II)‐POCOP Pincer Complexes and Their Cytotoxicity Evaluation Against Human Cancer Cell Lines
Authors: Sánchez‐Mora Arturo , Briñez Edwin , Pico Alejandro , González‐Sebastián Lucero , Antonio Cruz‐Navarrro J. , Arenaza‐Corona Antonino , Puentes‐Díaz Nicolás , Alí‐Torres Jorge , Reyes‐Márquez Viviana , Morales‐Morales David 
Published: July 2024

AbstractA series of three Ni(II)‐POCOP complexes para‐functionalized with an acetoxyl fragment were synthesized. All complexes (2 a–c) were fully characterized through standard analytical techniques. The molecular structure of complex 2 b was unambiguously determined by single‐crystal X‐ray diffraction, revealing that the metal center is situated in a slightly distorted square‐planar environment. Additionally, the acetoxy fragment at the para‐position of the phenyl ring was found to be present. The in vitro cytotoxic activity of all complexes was assessed on six human cancer cell lines. Notably, complex 2 b exhibited selective activity against K‐562 (chronic myelogenous leukemia) and MCF‐7 (mammary adenocarcinoma) with IC50 values of 7.32±0.60 μM and 14.36±0.02 μM, respectively. Furthermore, this compound showed negligible activity on the healthy cell line COS‐7, highlighting the potential therapeutic application of 2 b. The cytotoxic evaluations were further complemented with molecular docking calculations to explore the potential biological targets of complex 2 b, revealing interactions with cluster differentiation protein 1a (CD1 A, PDB: 1xz0) for K‐562 and with the progesterone receptor for MCF‐7.
Bis(benzimidazol‐2‐yl)amine‐Based DPP‐4 Inhibitors Potentially Suitable for Combating Diabetes and Associated Nervous System Alterations
Authors: Tomović Pavlović Katarina , Ilić Budimir S. , Leitzbach Luisa , Anichina Kameliya K. , Yancheva Denitsa , Živković Aleksandra , Mavrova Anelia Ts , Stark Holger , Šmelcerović Andrija 
Published: July 2024

AbstractBis(benzimidazol‐2‐yl)amine scaffold is not present in dipeptidyl peptidase‐4 (DPP‐4) inhibitors published so far. Herein, the inhibitory potential of bis(benzimidazol‐2‐yl)amine derivatives against DPP‐4 was evaluated. In non‐competitive inhibition mode, three representatives 5, 6, and 7 inhibited DPP‐4 in vitro with IC50 values below 50 μM. The assessed binding pocket of DPP‐4 for these benzimidazoles includes the S2 extensive subsite's residues Phe357 and Arg358. None of the lead compounds showed cytotoxicity to human neuroblastoma SH‐SY5Y cells at concentrations lower than 10 μM. None showed significant binding affinity at dopamine D2, D3, and histamine H1, H3 receptors, at concentrations lower than 10 μM, leading to preferable outcomes due to mutually opposite effects of these neurotransmitters on each other. The potential beneficial effects on dopamine synthesis and the survival of dopaminergic neurons could be mediated by DPP‐4 inhibition. These effective noncompetitive DPP‐4 inhibitors, with inhibitory potential better than reference diprotin A (relative inhibitory potency compared to diprotin A is 3.39 and 1.54 for compounds 7 and 5, respectively), with the absence of cytotoxicity to SH‐SY5Y cells, are valuable candidates for further evaluation for the treatment of diabetes and associated disruption of neuronal homeostasis.
Cyclopeptide Inhibitors Target the N‐Terminal Tail of STING and Alleviate Autoinflammation
Authors: Wang Xiaoquan , Cao Anqi , Zheng Wenlv , Quan Junmin 
Published: July 2024

AbstractCyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway is a crucial component of innate immunity that plays a vital role in protecting against pathogen infections and cellular stress. However, aberrant activation of cGAS‐STING pathway is related to inflammatory and autoimmune diseases. Here, we developed cyclopeptide STING inhibitors by cyclizing the N‐terminal tail (NTT) of STING. These cyclopeptides selectively inhibited the activation of STING pathway in human or murine cell lines. Mechanistically, the inhibitors directly bound to STING, and subsequently blocked the aggregation and activation of STING. In addition, the optimal inhibitor STi‐2 significantly suppressed proinflammatory cytokine production and systemic inflammation in Trex1−/− mice. Overall, our work facilitates the development of specific inhibitors of STING as potential therapies for cGAS‐STING associated autoinflammatory diseases.
Tuning Energetics of 2 e−/2H+ PCET Properties with Model Ru‐bisamido Complexes
Authors: Cattaneo Mauricio , Gallmeier Elisabeth T. , Abate Pedro O. , Mercado Brandon Q. , Mayer James M. 
Published: July 2024

AbstractMost redox processes that break/form bonds involve net 2e− changes, and many are coupled to protons. Yet most proton‐coupled electron transfer (PCET) studies focus on 1e−/1H+ reactions. Reported here is a family of molecular models that undergo tunable 2e−/2H+ redox changes. Complexes [(X2bpy)RuII(en*)2](PF6)2 and [(X2bpy)RuIV(en*‐H)2](PF6)2 have been synthesized with bpy=2,2’‐bipyridine with 4,4’‐subtitutions X=−NMe2, −OMe, −Me, −H, −CF3; and en*=2,3‐dimethyl‐2,3‐butanediamine. They have been characterized by IR, UV‐vis, and NMR spectroscopies, XRD, electrochemistry, mass spectrometry, DFT and (TD)DFT computations. The introduction of electron‐withdrawing and donating groups at the 4,4’‐position of the bpy ligand affects the complexes’ redox potentials, pKa’s, and Bond Dissociation Free Energies (BDFEs) of the N−H bonds in the en* ligands. The average BDFEs for the overall 2e−/2H+ PCET span over 5 kcal/mol. Notably, these complexes all show marked potential inversion over an extended range, ΔpKa>25 units and ΔE0>1.4 V. Potential inversion remains despite the electronic influence of bpy's substitutions which regulate N−H properties several bonds apart by trans‐effect over dπ‐molecular orbitals at the Ru center. The experimental and computational results presented in this work support the presence of strong coupling between electrons and protons, for modelling insights of 2e−/2H+ transfer reactivity.
Dimethylene‐Cyclopropanide Units as Building Blocks for Fluorescence Dyes
Authors: Yanbaeva Margarita , Soyka Jan , Holthoff Jana M. , Rietsch Philipp , Engelage Elric , Ruff Adrian , Resch‐Genger Ute , Weiss Robert , Eigler Siegfried , Huber Stefan M. 
Published: July 2024

AbstractMany organic dyes are fluorescent in solution. In the solid state, however, quenching processes often dominate, hampering material science applications such as light filters, light‐emitting devices, or coding tags. We show that the dimethylene‐cyclopropanide scaffold can be used to form two structurally different types of chromophores, which feature fluorescence quantum yields up to 0.66 in dimethyl sulfoxide and 0.53 in solids. The increased fluorescence in the solid state for compounds bearing malonate substituents instead of dicyanomethide ones is rationalized by the induced twist between the planes of the cyclopropanide core and a pyridine ligand.
Estimation of the additive hazards model based on case‐cohort interval‐censored data with dependent censoring
Authors: Ma Yuqing , Wang Peijie , Lou Yichen , Sun Jianguo ,   Alzheimer's Disease Neuroimaging Initiative
Published: July 2024

AbstractThe additive hazards model is one of the most commonly used models for regression analysis of failure time data, and many methods have been developed for its estimation. In this article, we consider the situation where one observes informatively interval‐censored data arising from case‐cohort studies where covariate information is collected only for a small subcohort of study subjects. By informative or dependent censoring, we mean that the failure time of interest and the censoring mechanism may be correlated. For estimation, we will develop a sieve inverse probability weighting estimation procedure with the use of Bernstein polynomials. The resulting estimators of regression parameters are shown to be consistent and asymptotically normal. An extensive simulation study is conducted and suggests that the proposed method works well in practical situations. An example is also provided.
Design of MOF‐Based Solar Evaporators With Hierarchical Microporous/Nanobridged/Nanogranular Structures for Rapid Interfacial Solar Evaporation and Fresh Water Collection
Authors: Li Lingxiao , Chen Kai , Zhang Jiaren , Zhang Junping 
Published: July 2024

AbstractInterfacial solar evaporation (ISE) holds considerable promise to solve fresh water shortage, but it is challenging to achieve high evaporation rate (Reva) and fresh water yield in close system. Here, we report design and preparation of MOF‐based solar evaporators with hierarchical microporous/nanobridged/nanogranular structures for rapid ISE and fresh water collection in close system. The evaporators are fabricated by growing silicone nanofilaments with variable length as nanobridges on a microporous silicone sponge followed by grafting with polydopamine nanoparticles and Cu‐MOF nanocrystals. Integration of the unique structure and excellent photothermal composites endows the evaporators with high Reva of 3.5–20 wt % brines (3.60–2.90 kg m−2 h−1 in open system and 2.38–1.44 kg m−2 h−1 in close system) under simulated 1 sun, high Reva under natural sunlight, excellent salt resistance and high fresh water yield, which surpass most state‐of‐the‐art evaporators. Moreover, when combined with a superhydrophilic cover, the evaporators show much higher average Reva of real seawater, remarkable fresh water yield and excellent long‐term stability over one month continuous ISE under natural sunlight. The findings here will promote the development of advanced evaporators via microstructure engineering and their real‐world ISE applications.
Sedimentary facies assemblages of the Selendi Supradetachment Basin (Western Turkey): Implications for balancing subsidence and sedimentation in a Neogene lacustrine basin
Authors: Ilgar Ayhan , Tuncay Ercan , Bozkurt Alper , Ergen Ali , Esirtgen Tolga 
Published: July 2024

AbstractThe Selendi Basin developed as a supradetachment basin on the Simav detachment fault in response to the continental extension in western Turkey (Türkiye) and the associated Menderes Massif uplift. Process‐based facies analyses were used to define and interpret the depositional evolution of the lacustrine Selendi Basin. The Early‐Middle Miocene deposits are composed of stream‐dominated alluvial fans, foreshore, shoreface, shoal‐water delta and offshore transition facies assemblages, which are laterally and vertically transitional throughout the succession. The alluvial fan and nearshore deposits reveal that the topography of the basin floor and the coastal plain was gently inclined. Shoal‐water deltas, 70–250 cm thick, in the delta complex reflect comparable water depths and a relative rise in lake level, ultimately attributable to basin subsidence. Shallow environmental conditions prevailed during the basin's evolution, as evidenced by widespread nearshore deposits along its southern margin. The facies assemblages forming the basin's southern part show a predominantly aggradational stacking pattern, recording a balance between the sediment supply and a steadily growing basin accommodation. The balanced fill deposition and aggradational stacking pattern of the sedimentary facies associations indicate that the rate of basin subsidence and the uplift of the Menderes Massif was relatively consistent. This study shows that the intensity of a synsedimentary fault system, especially one leading to basin opening, plays a crucial role in controlling the architecture and sedimentary facies of the basin succession, both by creating accommodation and by filling it.
‘Hot phase’ non‐dilated left ventricular cardiomyopathy with atypical onset and recurrence: a case report
Authors: Gonano Nicola , Nuzzi Vincenzo , Pavan Daniela , Piazza Rita , Pecoraro Rosa , Altinier Alessandro , Bussani Rossana , Sinagra Gianfranco , Merlo Marco 
Published: July 2024

AbstractNon‐dilated left ventricular cardiomyopathy (NDLVC) is a newly categorized cardiomyopathy phenotype includingseveral aetiologies with a linking characteristic represented by the normal left ventricular volume. Inflammatory heart disease (InHD) is a heterogeneous process with variegate clinical manifestations, sometimes in overlap with NDLVC. A 26‐year‐old woman was admitted forcomplete heart block (CHB) and persistently raised troponin. Echocardiography and coronary angiography were normal. Extensive oedema and late gadolinium enhancement was found at cardiac magnetic resonance. Endomyocardial biopsy showed no signs of active myocarditis. Steroid therapy was started with restoration of atrioventricular conduction but subsequently the patient experienced a mild recurrence with a new troponin relapse. Genetic test was negative for mutations related with the clinical scenario. In this case of NDLVC with InHD the precise diagnostic work‐up, including genetic test, was crucial for diagnostic, prognostic andtherapeutic purposes. Multimodality approach is crucial to detect and treat possible recurrences.