bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in treatment and outcomes of ankylosing spondylitis in outpatient rheumatological care in Germany between 2000 and 2012
Authors: Huscher Dörte , Thiele Katja , Rudwaleit Martin , Albrecht Katinka Charlotte , Bischoff Sascha , Krause Andreas , Karberg Kirsten , Wassenberg Siegfried , Zink Angela 
Published: May 2015

ObjectivesTo describe changes in drug treatment and clinical outcomes of ankylosing spondylitis (AS) during the past decade.MethodsThe national database of the German collaborative arthritis centres collects clinical and patient-derived data from unselected outpatients with inflammatory rheumatic diseases. Cross-sectional data from 2000 to 2012 of around 1000 patients with AS per year were compared with regard to clinical presentation and quality of life indicators.ResultsNon-steroidal anti-inflammatory drugs (NSAIDs) have been the predominant treatment choice in AS over the years with a prescription rate of 67% of patients in 2012. Currently, almost half of the patients with AS in German rheumatology centres are treated with tumour necrosis factor inhibitors (TNFi). Often, both treatments are used in combination (33%), followed by combinations of NSAIDs and synthetic disease modifying antirheumatic drugs (sDMARDs) with 23% or TNFi alone (21%). In 2012, 10% of patients each received NSAID or sDMARD monotherapy. Methotrexate, sulfasalazine, glucocorticoids and analgaesics alone or in combination with other treatments were given to 10% of patients, respectively. Over the years, we have seen remarkable improvements in disease control and patient reported outcomes. These developments are consistent with enhanced functional status, increasing employment rates and decreasing sick leave, hospitalisation and work disability.ConclusionsIn the German rheumatology secondary/tertiary care setting, routine care of patients with AS has changed tremendously during the past decade. Increasingly, more efficacious treatment options are reflected in improved clinical outcomes, quality of life and participation in the labour force.
Linear and Competitive Strategies for Continuous Robot Formation Problems
Authors: Degener Bastian , Kempkes Barbara , Kling Peter , Heide Friedhelm Meyer Auf Der 
Published: May 2015

We study a scenario in which
n
mobile robots with a limited viewing range are distributed in the Euclidean plane and have to solve a formation problem. The formation problems we consider are the G
athering
problem and the C
hain-Formation
problem. In the G
athering
problem, the robots have to gather in one (not predefined) point, while in the C
hain
-F
ormation
problem they have to form a connected communication chain of minimal length between two stationary base stations. Each robot may base its decisions where to move only on the current relative positions of neighboring robots (that are within its viewing range); that is, besides having a limited viewing range, the robots are oblivious (they do not use information from the past), have none or only very limited identities, and they do not have a common sense of direction.

Variants of these problems (especially for the G
athering
problem) have been studied extensively in different discrete time models. In contrast, our work focuses on a continuous time model; that is, the robots continuously sense the positions of other robots within their viewing range and continuously adapt their speed and direction according to some simple, local rules. Hereby, we assume that the robots have a maximum movement speed of one. We show that this idealized idea of continuous sensing allows us to solve the mentioned formation problems in linear time O(
n
) (which, given the maximum speed of one, immediately yields a maximum traveled distance of O(
n
)). Note that in the more classical discrete time models, the best known strategies need at least Θ(
n
2
) or even Θ(
n
2
log
n
) timesteps to solve these problems. For the G
athering
problem, our analysis solves a problem left open by Gordon et al. [2004], where the authors could prove that gathering in a continuous model is possible in finite time, but were not able to give runtime bounds.

Apart from these linear bounds, we also provide runtime bounds for both formation problems that relate the runtime of our strategies to the runtime of an optimal, global algorithm. Specifically, we show that our strategy for the G
athering
problem is log OPT-competitive and the strategy for the C
hain
-F
ormation
problem is log
n
-competitive. Here, by
c
-competitive, we mean that our (local) strategy is asymptotically by at most a factor of
c
slower than an optimal, global strategy.
Constant Delay Enumeration for Conjunctive Queries
Authors: Segoufin Luc 
Published: May 2015

We survey some of the recent results about enumerating the answers to queries over a database. We focus on the case where the enumeration is performed with a constant delay between any two consecutive solutions, after a linear time preprocessing.
This cannot be always achieved. It requires restricting either the class of queries or the class of databases.
We consider conjunctive queries and describe several scenarios when this is possible.
Popliteal vein repair may not impact amputation rates in combined popliteal artery and vein injury
Authors: Dua Anahita , Desai Sapan S , Ali Fadwa , Yang Kai , Lee Cheong 
Published: May 2015

Introduction This study aimed to determine the incidence, management, and outcomes of popliteal artery injury, popliteal vein injury, and concomitant popliteal artery injury and vein injury. Methods A retrospective analysis was completed using the 2000–2010 Nationwide Inpatient Sample utilizing International Classification of Diseases-9 codes to select patients with isolated popliteal artery injury (904.41), isolated popliteal vein injury (904.42), and isolated concomitant popliteal artery and vein injury (958.92). Variables included demographics, procedure type, and outcome during hospital course. Statistical analysis was with chi-square, Fisher exact test, and multivariate analysis. Results A total of 2216 patients presented with injury to the popliteal system; 71% (1568) presented with isolated popliteal artery injury, 14% (306) with isolated popliteal vein injury, and 15% (342) with concomitant popliteal artery and vein injury. Amputation was significantly increased in popliteal artery injury and concomitant popliteal artery and vein injury ( P < 0.001) as compared to popliteal vein injury. Ligation of the vein was more common in concomitant popliteal artery and vein injury when compared to popliteal vein injury ( P < 0.05). The rate of amputation was 9.8% for popliteal artery injury, significantly greater than for popliteal vein injury (0.7%, P < 0.001) but not different than for concomitant popliteal artery and vein injury (8.2%, P = NS). Conclusion Evidence-based management of popliteal vasculature may increase rates of limb salvage. Within the limitations of the data set used, conclusions appear to be that patients with popliteal vein injury or concomitant popliteal artery and vein injury may be managed with vein ligation without increased amputation rates as compared to popliteal artery injury.
Gold Nanohole Array with Sub-1 nm Roughness by Annealing for Sensitivity Enhancement of Extraordinary Optical Transmission Biosensor
Authors: Zhang Jian , Irannejad Mehrdad , Yavuz Mustafa , Cui Bo 
Published: May 2015

Abstract
Nanofabrication technology plays an important role in the performance of surface plasmonic devices such as extraordinary optical transmission (EOT) sensor. In this work, a double liftoff process was developed to fabricate a series of nanohole arrays of a hole diameter between 150 and 235 nm and a period of 500 nm in a 100-nm-thick gold film on a silica substrate. To improve the surface quality of the gold film, thermal annealing was conducted, by which an ultra-smooth gold film with root-mean-square (RMS) roughness of sub-1 nm was achieved, accompanied with a hole diameter shrinkage. The surface sensitivity of the nanohole arrays was measured using a monolayer of 16-mercaptohexadecanoic acid (16-MHA) molecule, and the surface sensitivity was increased by 2.5 to 3 times upon annealing the extraordinary optical transmission (EOT) sensor.
Connectivity and circuitry in a dish versus in a brain
Authors: Chinchalongporn Vorapin , Koppensteiner Peter , Prè Deborah , Thangnipon Wipawan , Bilo Leonilda , Arancio Ottavio 
Published: May 2015

AbstractIn order to understand and find therapeutic strategies for neurological disorders, disease models that recapitulate the connectivity and circuitry of patients’ brain are needed. Owing to many limitations of animal disease models, in vitro neuronal models using patient-derived stem cells are currently being developed. However, prior to employing neurons as a model in a dish, they need to be evaluated for their electrophysiological properties, including both passive and active membrane properties, dynamics of neurotransmitter release, and capacity to undergo synaptic plasticity. In this review, we survey recent attempts to study these issues in human induced pluripotent stem cell-derived neurons. Although progress has been made, there are still many hurdles to overcome before human induced pluripotent stem cell-derived neurons can fully recapitulate all of the above physiological properties of adult mature neurons. Moreover, proper integration of neurons into pre-existing circuitry still needs to be achieved. Nevertheless, in vitro neuronal stem cell-derived models hold great promise for clinical application in neurological diseases in the future.
Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice
Authors: Ma Lan , Aijima Reona , Hoshino Yoshihiro , Yamaza Haruyoshi , Tomoda Erika , Tanaka Yosuke , Sonoda Soichiro , Song Guangtai , Zhao Wei , Nonaka Kazuaki , Shi Songtao , Yamaza Takayoshi 
Published: May 2015

Abstract
Introduction
Secondary osteoporosis is common in systemic lupus erythematosus and leads to a reduction in quality of life due to fragility fractures, even in patients with improvement of the primary disorder. Systemic transplantation of mesenchymal stem cells could ameliorate bone loss and autoimmune disorders in a MRL/lpr mouse systemic lupus erythematosus model, but the detailed therapeutic mechanism of bone regeneration is not fully understood. In this study, we transplanted human bone marrow mesenchymal stem cells (BMMSCs) and stem cells from exfoliated deciduous teeth (SHED) into MRL/lpr mice and explored their therapeutic mechanisms in secondary osteoporotic disorders of the systemic lupus erythematosus model mice.

Methods
The effects of systemic human mesenchymal stem cell transplantation on bone loss of MRL/lpr mice were analyzed in vivo and ex vivo. After systemic human mesenchymal stem cell transplantation, recipient BMMSC functions of MRL/lpr mice were assessed for aspects of stemness, osteogenesis and osteoclastogenesis, and a series of co-culture experiments under osteogenic or osteoclastogenic inductions were performed to examine the efficacy of interleukin (IL)-17-impaired recipient BMMSCs in the bone marrow of MRL/lpr mice.

Results
Systemic transplantation of human BMMSCs and SHED recovered the reduction in bone density and structure in MRL/lpr mice. To explore the mechanism, we found that impaired recipient BMMSCs mediated the negative bone metabolic turnover by enhanced osteoclastogenesis and suppressed osteoblastogenesis in secondary osteoporosis of MRL/lpr mice. Moreover, IL-17-dependent hyperimmune conditions in the recipient bone marrow of MRL/lpr mice damaged recipient BMMSCs to suppress osteoblast capacity and accelerate osteoclast induction. To overcome the abnormal bone metabolism, systemic transplantation of human BMMSCs and SHED into MRL/lpr mice improved the functionally impaired recipient BMMSCs through IL-17 suppression in the recipient bone marrow and then maintained a regular positive bone metabolism via the balance of osteoblasts and osteoclasts.

Conclusions
These findings indicate that IL-17 and recipient BMMSCs might be a therapeutic target for secondary osteoporosis in systemic lupus erythematosus.
Overlapping PPM for band-limited visible light communication and dimming
Authors: Gancarz John E. , Elgala Hany , Little Thomas D.C. 
Published: May 2015

Abstract
The synthesis of visible light communication (VLC) and lighting state control necessitates data-light modulation that can accommodate intensity control. A number of techniques that enable both optical wireless data transmission and intensity control of light-emitting diodes (LEDs) have been proposed as a response to this need. Relevant schemes leverage amplitude modulation (AM)/continuous current reduction (CCR) and/or pulse-width modulation (PWM) for dimming capability. Two-level schemes related to PWM, such as on-off keying with compensation time (OOK + CT), variable pulse position modulation (VPPM), and multiple pulse position modulation (MPPM), are most commonly investigated. In this paper, we survey and compare OOK + CT, VPPM and MPPM. Moreover, we propose a novel approach towards dimming and data transmission through the variation of codeword weights in overlapping pulse-position modulation (OPPM). The proposed approach has comparatively high spectral efficiency. Using realistic constraints of a practical VLC system, analysis reveals that OPPM can increase data rates by more than 20Mbps over expected performance of related, two-level schemes, when using LEDs suitable for lighting that have relatively low modulation bandwidths.
Long and short range order structural analysis of
In-situ
formed biphasic calcium phosphates
Authors: Kim Dong-Hyun , Hwang Kyu-Hong , Lee Ju Dong , Park Hong-Chae , Yoon Seog-Young 
Published: May 2015

Abstract

Background

Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of
in-situ
formed BCP consisting of hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) were controlled by the degree of calcium deficiency of precursors. The long and short range order structures of biphasic mixtures was investigated using Rietveld refinement technique and high resolution Raman spectroscopy. The refined structural parameters of
in-situ
formed BCP confirmed that all the investigated structures have crystallized in the corresponding hexagonal (space group P63/m) and rhombohedral (space group R3c) structures.

Results

The crystal phases, Ca/P molar ratio, and lattice parameters of
in-situ
formed BCP consisting of HAp and β-TCP were controlled by the degree of calcium deficiency of calcium phosphate precursors. The significant short range order structural change of BCP was determined by Raman analysis.

Conclusions

The long and short range order structural changes of
in-situ
formed BCP might be due to the coexistence of β-TCP and HAp crystal phases.
Art and epistemic injustice: Ursula Biemann’s Remote Sensing and The Black Sea Files
Authors: Brown Kathryn 
Published: May 2015

Abstract
Having regard to two video works produced by Ursula Biemann, Remote Sensing (2001) and The Black Sea Files (2005), this article examines the portrayal of female displacement and migration in the context of Miranda Fricker’s recent discussion of ‘epistemic injustice’. Focusing on ways in which the videos demonstrate instances of testimonial injustice, it is argued that Biemann’s work requires audiences to broaden their conception of the circumstances in which such injustice might arise. The discussion shows that Remote Sensing and The Black Sea Files do not just illuminate the distinctive harm of testimonial injustice, but also deepen current debates in analytical philosophy about the ways in which social pressures, customs, and power structures impact on the provision and receipt of testimony. Instead of viewing the exercise of prejudice as the trigger for testimonial injustice, Biemann’s works show that such injustice can arise when listeners fail to have regard to the background socio-economic conditions that shape the context in which testimony is given and received. By self-consciously locating her works in a network of image circulation, Biemann also raises questions about the reliability of moving images that seek to illuminate testimonial injustice at the intersection of art and documentary.
Art, artifice and androgyny: Roxy Music’s dandy modernism
Authors: Hackett Jon 
Published: May 2015

Abstract
This article considers glam rock’s rejection of the humdrum, spontaneity and the ‘natural’, and its embrace of costuming, camp and artificiality. With particular reference to Roxy Music, it will examine the band’s iconography, fashion and contexts during glam’s golden years – 1972 to 1974 – as well as the implications of glam style for gender and sexuality in popular music. Though some of glam’s exponents were undoubtedly much more traditional in their performance of gender identities, we can read bands like Roxy Music, within certain limits, as ‘queering’ their more meat-and-potatoes predecessors and providing an important source of identification for later pop music gender and style dissidents. The fashion and music scenes in which Roxy Music emerged are inseparable from the milieux of experimentation and innovation associated with British art and fashion schools in the 1960s onwards. To this extent, the band exemplifies the vital pathway of art school students into popular music outlined by Simon Frith and Howard Horne in Art into Pop. Through Keir Keightley’s conception of romantic and modernist authenticity in popular music and Joanne Entwhistle’s genealogy of the romantic and the dandy in fashion, we will explore how glam traces a line from the dandy via New Edwardian fashion, in which questions of gender and artifice are in a process of perpetual renegotiation.
Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes
Authors: Lasek Witold , Janyst Michał , Wolny Rafał , Zapała Łukasz , Bocian Katarzyna , Drela Nadzieja 
Published: May 2015

Abstract
Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. In the present study, effects of Inos on the production of cytokines attributable to Th1 (IL-2, IFN-g, and TNF-a) or Th2 cells (IL-4, IL-5, and IL-10) were tested in human peripheral blood lymphocyte cultures stimulated with phytohemagglutinin (PHA). Inos enhanced TNF-a secretion significantly (in short-term - 24-hour, and prolonged term - 72-hour cultures) and IFN-g (in 72-hour cultures). Surprisingly, production of IL-10 by PHA-stimulated lymphocytes was suppressed by Inos in a dose-dependent manner in both 24-hour and 72-hour cultures. These results shed some light on immunomodulatory properties of Inos and suggest applicability of this agent in patients with a depressed function of the immune system.
Analytical performances of the D-100TM hemoglobin testing system (Bio-Rad) for HbA1c assay
Authors: Jaisson Stéphane , Leroy Nathalie , Guillard Emmanuelle , Desmons Aurore , Gillery Philippe 
Published: May 2015

AbstractGlycated hemoglobin (HbAThe analytical performances of the method as well as the influence of the most frequent interferences regarding HbAIntra- and between-assay CVs were respectively lower than 0.93% and 1.46% (HbAThe D-100
The Comparison of Measured and Simulated Dynamic Responses of Vehicles Indicated by Road Pavement Unevenness
Authors: Decký Martin , Kováč Matúš , Kotek Peter 
Published: May 2015

Abstract
The article presents the comparison of measured and simulated dynamic responses of heavy vehicle which are indicated by road pavement unevenness. This unevenness was represented by speed control bumps, potholes and stochastic pavement unevenness. The objective simulations were realized through the medium Quarter- Car Simulation by means of application of simulated theory of dynamic systems. The reliability of used model was verificated with comparison of measured and simulated values of sprung mass T815 vehicle accelerations. In the article, there are presented courses of total vertical forces of Quarter-Car Simulation for the first, the second and the fourth classification degree of unevenness, which was considered through the world's respected parameter IRI (International Roughness Index). Obtained simulated dynamic effects of the vehicle on the pavement were used for modification of a relevant Slovak design method of asphalt pavements.
Simulator of Road Tunnel
Authors: Danišovič Peter , Schlosser František , Šrámek Juraj , Rázga Martin 
Published: May 2015

Abstract
A Tunnel Traffic & Operation Simulator is a device of the Centre of Transport Research at the University of Žilina. The Simulator allows managing technological equipment of virtual two-tube highway tunnel, which is interconnected with simulation of vehicle traffic in tunnel. Changes of the traffic-operation states and other equipment are reflecting at the simulated traffic, as well as simulations of various emergency events in traffic initiate changes in tunnel detecting and measuring devices. It is thus possible to simulate emergency states, which can be affected by various faults of technology as well as by climatic conditions. The solutions can be found in irreplaceable experiences of Slovak road tunnel operators, changes of trafficoperation states, visualizations of operator technological display screens, technological devices labelling in order to increase operational safety of road tunnels.
Fire Protection in Various Types of Wooden Structures
Authors: Gašpercová Stanislava , Makovická Osvaldová Linda 
Published: May 2015

Abstract
Design of new modern systems for low energy efficient construction in a passive, zero standard or energy-autonomous buildings, as well as the increased popularity of solid wood construction means intervention into the very structure of its statics, building physics, but also fire properties. Some prototype design solutions are not verified whether the tests, by good computational analysis or verification of long-term use of the building. In the context of changing standards in building design, new approaches are needed. If in wooden buildings the potential risk of fire is higher than other buildings, we need special methods, materials and practical skills.