bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Uncertainty Blows in the Orchard: Comovement and Equilibrium Volatility Risk Premia
Authors: BURASCHI ANDREA , TROJANI FABIO , VEDOLIN ANDREA 
Published: October 2013

ABSTRACTWe provide novel evidence for an equilibrium link between investors' disagreement, the market price of volatility and correlation, and the differential pricing of index and individual equity options. We show that belief disagreement is positively related to (i) the wedge between index and individual volatility risk premia, (ii) the different slope of the smile of index and individual options, and (iii) the correlation risk premium. Priced disagreement risk also explains returns of option volatility and correlation trading strategies in a way that is robust to the inclusion of other risk factors and different market conditions.
Prognostic significance of thrombocytosis, platelet parameters and aggregation rates in epithelial ovarian cancer
Authors: Ma Xuegong , Wang Yingmei , Sheng Hongna , Tian Wenyan , Qi Zheng , Teng Fei , Xue Fengxia 
Published: October 2013

AbstractAimThe aim of this study is to investigate the impact of preoperative platelet counts, parameters and aggregation rates (maximal aggregation rate: MAR) on prognosis in patients with epithelial ovarian cancer (EOC).MethodsPreoperative platelet count, parameters and MAR in 182 EOC patients, 122 patients with benign ovarian tumor and 150 healthy women were retrospectively analyzed. The correlation between thrombocytosis, platelet parameters, MAR and clinicopathological factors were evaluated in EOC.ResultsForty‐five (24.73%) EOC patients had preoperative thrombocytosis in this study. The mean platelet count in the EOC group was significantly higher than that of benign and healthy groups (P < 0.001). The MAR in the EOC group was significantly higher than that in the healthy group (71.96% vs 57.03%, P = 0.025). The platelet parameters (mean platelet volume, platelet distribution width, thrombocytocrit and large platelet ratio) were consistently higher in the EOC group than those in the benign and healthy groups, but the differences were insignificant. A significant correlation between thrombocytosis and MAR was observed in EOC patients (r = 0.694, P < 0.001). EOC patients with thrombocytosis were found to have significantly higher grade (P = 0.048), more advanced stage (P = 0.045), higher level carbohydrate antigen‐125 (P = 0.007) and greater likelihood of suboptimal cytoreduction (P = 0.035). EOC patients with both thrombocytosis and high MAR were found to have shorter progression‐free survival (P = 0.001)and overall survival (P = 0.004). The combination of thrombocytosis and MAR, as well as stage and optimal cytoreduction, retained significance as an independent prognostic factor for overall survival.ConclusionThrombocytosis, accompanied by increasing of platelet aggregation rates, is associated with more aggressive tumor biology in EOC. The combination of thrombocytosis and MAR is an independent negative prognostic factor for overall survival in EOC patients.
Maternal floor infarction: Management of an underrecognized pathology
Authors: Al‐Sahan Nada , Grynspan David , von Dadelszen Peter , Gruslin Andrée 
Published: October 2013

AbstractMaternal floor infarction is a relatively rare condition characterized clinically by severe early onset fetal growth restriction with features of uteroplacental insufficiency. It has a very high recurrence rate and carries a significant risk or fetal demise. Pathological characteristics include massive and diffuse fibrin deposition along the decidua basalis and the perivillous space of the basal plate. We present a case of recurrent maternal floor infarction and propose diagnostic clues as well as potential therapeutic options.
Associations for birthweight of twin pairs in south India
Authors: Singh Arati , Singh Anupama , Nirmalan Praveen K. 
Published: October 2013

AbstractAimThe aim of this study was to determine the distribution and associations of birthweight in twin pairs among a population of pregnant women in south India.Material and MethodsThis was a retrospective case record analysis of 705 twin pair pregnancies during the period 2008–2012. Associations of birthweight with maternal age, parity, pregnancy‐induced hypertension (PIH), gestational diabetes, obesity, chorionicity and sex of the twin pairs was explored using bivariate and multivariate analysis.ResultsThe median birthweight (4250 g, interquartile range 3530–4810) of dichorionic twins was significantly higher (P < 0.0001) than monochorionic twins (3880 g, interquartile range 3000–4380). Birthweight was associated with chorionicity (t = 4.04, P < 0.001), obesity (t = 2.44, P = 0.03), nulliparity (t = −2.87, P = 0.004), and PIH (t = −2.11, P = 0.04) in a multivariate linear regression model. Birthweights did not differ significantly between female–male and female–female pairs (t = 0.11, P = 0.81), female–male and male–male pairs (t = −0.62, P = 0.54) or female–female and male–male pairs (t = −0.78, P = 0.43) in a multivariate linear regression model. The highest birthweight of the twin pair did not differ significantly (t = 1.27, P = 0.21) by sex of the twin.ConclusionsBirthweight of twins was significantly associated with chorionicity, obesity, PIH and nulliparity in this population. A potential masculinization effect was not found as the total birthweights did not differ significantly by sex of the twin pairs.
Durable response after just one cycle of belotecan‐based chemotherapy in a patient with relapsed primary peritoneal serous carcinoma
Authors: Lee Guk Jin , Min Ji Won , Seo Min Wu , Lee Mi Yeong , Jin Jong Youl 
Published: October 2013

AbstractThe efficacy of second‐line chemotherapy for relapsed primary peritoneal serous carcinoma has been numerously reported, but reports on durable response after second‐line therapy have been rare. We report the case of a 66‐year‐old woman with relapsed primary peritoneal serous carcinoma who showed durable response after just one cycle of second‐line belotecan‐based therapy. The response might be a complete pathologic remission. Considering the fact that our patient suffered from neutropenic sepsis during her treatment, we concluded that belotecan‐based chemotherapy could be a good option for second‐line chemotherapy in some selected patients, so patient selection should be carefully performed due to the toxicity of belotecan.
All Things Thrown and Wonderful, All Memories Great and Small
Authors: Wilkinson Alex 
Published: October 2013

AbstractAnd the Lord God made them all. I went to Sunday school and like lots of other kids (though far from all) came to an age at which I simply stopped going. Nothing conscious about it, I don't think, it's just those sets of spaces stopped becoming; stopped like nothing physical can stop, like a car crashing into a wall and instead of rebounding being merely consumed in whole. I (re)member, in my naive teens (when is this? I do not know. Perhaps the time of the Iraq war, but maybe this was a different car journey) I once came out with the statement (which was not particularly naive especially) “I think God exists, how did we all get here otherwise”. Me, my sister that is two years older than me, my mum and dad, were on the road from Auchmuir Bridge towards Stirling around Loch Leven, the loch in Fife, Scotland, on which Mary Queen of Scots was held on an island. I have an image of a memory of going there as well. It is thus, however, that I (re)member the initiation into a different vision of the universe and everything. Yet it is a state clearly pleated bewilderingly. As an event it exists in what Deleuze and Guattari term a “rhizome, a burrow”, with “flights of escape” which have no beginnings or ends, mere initialities and finalities. This is strange. It is not a polemic, nor does it have an explicit argument, except perhaps to ask the question that always dances on a pinhead – as Bohumil Hrabal once put it, “Pirouettes on a Postage Stamp” – is there any escape? I think I sang “All Things Bright and Beautiful” at my Gran's funeral, but it might have been something else. We stopped in the house of the priest and watched England lose the Cricket World Cup in 1999; they played in blue. That's how I (re)member the year of my Gran's funeral. The church I used to go to burned down. Arson, I think.
Association of oral health behaviors and status with depression: results from the Korean National Health and Nutrition Examination Survey, 2010
Authors: Park Se Jin , Ko Ki Dong , Shin Seung‐Il , Ha Yu Jeong , Kim Gy Young , Kim Hyoung Ah 
Published: October 2013

AbstractObjectiveTo examine the association of depression with oral health behaviors and oral health status in a large nationwide sample of Korean adults.MethodsThis study included 6,139 participants aged 19 years or older who participated in the fifth Korean National Health and Nutrition Examination Survey. Binary and polychotomous logistic regression analyses were used to estimate adjusted odds ratios (AORs) and 95 percent confidence intervals (CIs).ResultsParticipants with lifetime depression (self‐report of past or present depression) brushed their teeth less frequently (AOR = 1.30, 95 percent CI 1.03‐1.65) and were more likely not to receive treatment when experiencing dental problems (AOR = 1.43, 95 percent CI 1.23‐1.66) than those without lifetime depression after adjusting for sociodemographic factors, gender, and age. After adjusting for significant oral health behaviors, current smoking status, and sociodemographic factors, participants with lifetime depression had poorer oral health status than those without this disorder: uncomfortable mastication (AOR = 1.25, 95 percent CI 1.05‐1.50), toothache (AOR = 1.18, 95 percent CI 1.01‐1.39), temporomandibular joint symptoms (AOR = 1.41, 95 percent CI 1.08‐1.85), and maxillary periodontal bleeding (AOR = 1.29, 95 percent CI 1.03‐1.61 for the right side; AOR = 1.40, 95 percent CI 1.13‐1.74 for the left side).ConclusionDepression was significantly associated with oral health status, even after adjusting for the impact of oral health behaviors in Korean adults. Thus, our findings suggest the necessity of further investigation to detect underlying mechanisms in the relationship between depression and oral health that are not mediated by oral health behavior.
Effects of carboxy methyl cellulose and thymol + carvacrol on performance, digesta viscosity and some blood metabolites of broilers
Authors: Hashemipour H. , Kermanshahi H. , Golian A. , Khaksar V. 
Published: October 2013

SummaryThis study was conducted to evaluate the effects of thymol + carvacrol as plant essential oils on performance, digesta viscosity and some blood metabolites of broilers fed diets supplemented with carboxy methyl cellulose (CMC) and/or thymol+carvacrol. In a completely randomized design with a 2 × 3 factorial arrangement, two levels of CMC (0% and 2%) and three levels of thymol+carvacrol (0, 100 and 200 mg/kg) were used. Each of the six dietary treatments was fed to five replicate pens of 12 birds each from 0 to 42 days of age. Body weight gain (BWG), feed intake, feed conversion ratio (FCR), intestinal digesta viscosity and pH, plasma lipids and some blood metabolites were recorded. The inclusion of 2% CMC decreased (p < 0.05) BWG by 2.2% and increased FCR by 2.3% at 42 days of age. Carboxy methyl cellulose significantly increased the digesta viscosity and decreased serum total cholesterol, but had no significant effect on triglyceride, pH, HDL, LDL and other blood metabolites measured in this experiment. Thymol+carvacrol had no effect on feed intake, but significantly increased (p < 0.05) BWG from 1 to 42 days of age and improved FCR (p < 0.05) by the addition of 100 and 200 mg/kg thymol+carvacrol respectively. Inclusion of thymol+carvacrol at levels of 100 and 200 mg/kg in the diets decreased digesta viscosity and serum total cholesterol (p < 0.05) and also increased AST at a 200 mg/kg thymol+carvacrol without any effect on creatine kinase (CK). Thymol+carvacrol significantly increased total protein (TP), albumin and globulin (p < 0.05). In conclusion, CMC at an inclusion level of 2% of diet increased digesta viscosity and reduced growth performance. However, thymol+carvacrol decreased digesta viscosity and consequently improved the performance of broilers fed the CMC‐based diet. Therefore, thymol+carvacrol addition to viscose‐based diets might be helpful to alleviate the negative effects of viscous compounds in poultry diets.
Field evidence of smoke‐stimulated seedling emergence and establishment in Mediterranean Basin flora
Authors: Tormo J. , Moreira B. , Pausas J.G. 
Published: October 2013

AbstractQuestionIn many plant species from fire‐prone ecosystems germination is promoted by smoke. Mediterranean Basin (MB) flora is no exception. However, most information regarding germination response to smoke in the MB comes from a few experiments performed in laboratory conditions. This approach does not consider factors that occur in the field, such as species interactions, density‐dependent processes or the fact that seeds spent time in the soil seed bank. In addition, species selection has been biased (e.g. there is a lack of information about annual species). Hence the importance of smoke relative to other fire cues is not clear, and we have a biased knowledge of post‐fire community assembly in the MB. In this framework, we tested the following hypotheses: (1) smoke enhances seedling emergence and establishment from the soil seed bank of MB species, and (2) annual species are an important component of this smoke‐stimulated flora.LocationMediterranean fire‐prone shrublands in eastern Spain. Western Mediterranean Basin.MethodsWe performed a field experiment in which we applied a liquid smoke treatment and tracked seedling emergence and seedling establishment during 1 yr. Differences between smoke and control subplots with respect to seedling emergence and seedling establishment were analysed at different scales: community, growth form (annual or perennial), family and species level.ResultsAt the community level, smoke played a clear role in seedling recruitment, increasing seedling emergence and seedling establishment. In addition, for most plots, families and species, establishment was higher in smoke subplots compared to the control. Annual species establishment was clearly stimulated by smoke but no effect was detected for perennials.ConclusionsSmoke derived from wildfires has a key effect on plant recruitment and hence on community assembly in the MB vegetation.
Domestic Gothic: Genre and Nation in Charlotte Smith's The Old Manor House
Authors: Russell Deborah 
Published: October 2013

Abstract‘The Gothic novel’ is by no means a coherent entity, but it has its genesis in a turn to an imagined past. In considering late 18th‐century Gothic fiction, the impact of the broader historico‐political discourse surrounding the Gothic should be taken into account. Understanding this as a diverse and contested genre preoccupied with national history refocuses attention on a range of texts that are usually considered atypical of the Gothic, and turns a spotlight on novels that use Gothic tropes in domestic, British settings. It creates an especially rewarding approach to the fiction of Charlotte Smith, in which Gothic imagery is used to explore superstition, heritage and oppression in contemporary Britain. This article focuses on The Old Manor House (1793), arguing that to define the Gothic primarily in relation to Ann Radcliffe's novels of terror is to elide the other implications of the genre's key images, language and themes. In this novel, Smith uses several manifestations of the Gothic to create a sustained exploration of history and romance, of the mythmaking process that goes into the creation of personal and national identity, and to interrogate political systems of property and power.
New Approaches to the Queer 18th Century
Authors: Roulston Chris 
Published: October 2013

AbstractThis essay outlines some of the current debates on queer history, in particular Laura Doan's concept of “queer critical history” and Madhavi Menon's concept of “unhistoricism”, and examines how they engage with the field of queer 18th‐century studies. Due to its unique historical position on the cusp of the modern era, as well as the hegemonic discourses associated with the Enlightenment, including the rise of the bourgeoisie, the 18th century is sometimes perceived as dominated by an emerging heteronormativity. However, a brief survey of recent essay collections reveals instead the radical potential of 18th‐century discourses on sexuality and the period's openness to queer readings.
Recent official policy and concepts of reading comprehension and inference: the case of England's primary curriculum
Authors: Williams Jazz C. 
Published: October 2013

AbstractThis article engages with recent policy on reading comprehension. It argues that the construct of inference has been treated as a single entity despite research and literature to the contrary, and this is perpetuated in the National Curriculum for 2014. It explores the limitations of conceptualising inference as a unitary construct and demonstrates that official policy has confused progression in inference with the process of a reader building a mental representation of a text. It argues that criterion‐referenced statements for progression in inference are flawed. The article proposes a means of conceptualising inference so it can be operationalised for the purpose of teaching and learning in the classroom. This is exemplified and applied to an example of a standardised test.
Strong prediction of virological response to combination therapy by IL28B gene variants rs12979860 and rs8099917 in chronic hepatitis C genotype 4
Authors: Ragheb Mostafa M. , Nemr Nader A. , Kishk Rania M. , Mandour Mohamed F. , Abdou Mohamed M. , Matsuura Kentaro , Watanabe Tsunamasa , Tanaka Yasuhito 
Published: October 2013

AbstractBackgroundA strong association between single nucleotide polymorphisms (SNPs) of IL28B and treatment outcomes of pegylated interferon‐α (PEG IFNα) and ribavirin (RBV) has been shown in chronic hepatitis C (CHC) patients with genotype 1.AimThis study aimed to assess two SNPs of IL28B, rs12979860 and rs8099917, in predicting sustained virological responses (SVR) to treatment of CHC patients with genotype 4 (HCV‐4). The value of rs8099917 was investigated in carriers of unfavourable genotypes of rs12979860.MethodsThis study included 119 CHC patients with HCV‐4 receiving combination therapy. Both SNPs of IL28B were determined by real‐time detection polymerase chain reaction.ResultsGenotypes CC/CT/TT of rs12979860 were found in 42 (35.3%), 56 (47.1%) and 21 (17.6%) and rs8099917 TT/TG/GG were found in 74 (62.2%), 40 (33.6%) and 5 (4.2%). In carriers of rs12979860 CC and rs8099917 TT, the rate of SVR was 87.5 and 65.7% respectively. In 54 patients heterozygous for the C allele of rs12979860, testing of rs8099917 revealed SVR in 42.3% of carriers of the TT genotype but no such responses in carriers of TG or GG (P < 0.0001, OR = 47.3, 95% CI: 2.33–767.2). By multivariate analysis, predictors of SVR were baseline ALT (P = 0.014, OR = 6.3, 95% CI: 1.45–27.33), rs12979860 CC (P = 0.001, OR = 13.48, 95% CI: 2.95–61.69) and rs8099917 TT (P = 0.027, OR = 7.5, 95% CI: 1.25–44.88).ConclusionIn CHC genotype 4 patients, favourable genotypes of both SNPs of IL28B are valuable for predicting SVR. Additional genotyping of rs8099917 in carriers of the heterozygous C allele of rs12979860 can improve the prediction of SVR.
Improved fibrosis staging by elastometry and blood test in chronic hepatitis C
Authors: Calès Paul , Boursier Jérôme , Ducancelle Alexandra , Oberti Frédéric , Hubert Isabelle , Hunault Gilles , de Lédinghen Victor , Zarski Jean‐Pierre , Salmon Dominique , Lunel Françoise ,   the ANRS HC EP 23 Fibrostar Study
Published: October 2013

AbstractAimsOur main objective was to improve non‐invasive fibrosis staging accuracy by resolving the limits of previous methods via new test combinations. Our secondary objectives were to improve staging precision, by developing a detailed fibrosis classification, and reliability (personalized accuracy) determination.MethodsAll patients (729) included in the derivation population had chronic hepatitis C, liver biopsy, 6 blood tests and Fibroscan. Validation populations included 1584 patients.ResultsThe most accurate combination was provided by using most markers of FibroMeter and Fibroscan results targeted for significant fibrosis, i.e. ‘E‐FibroMeter’. Its classification accuracy (91.7%) and precision (assessed by F difference with Metavir: 0.62 ± 0.57) were better than those of FibroMeter (84.1%, P < 0.001; 0.72 ± 0.57, P < 0.001), Fibroscan (88.2%, P = 0.011; 0.68 ± 0.57, P = 0.020), and a previous CSF‐SF classification of FibroMeter + Fibroscan (86.7%, P < 0.001; 0.65 ± 0.57, P = 0.044). The accuracy for fibrosis absence (F0) was increased, e.g. from 16.0% with Fibroscan to 75.0% with E‐FibroMeter (P < 0.001). Cirrhosis sensitivity was improved, e.g. E‐FibroMeter: 92.7% vs. Fibroscan: 83.3%, P = 0.004. The combination improved reliability by deleting unreliable results (accuracy <50%) observed with a single test (1.2% of patients) and increasing optimal reliability (accuracy ≥85%) from 80.4% of patients with Fibroscan (accuracy: 90.9%) to 94.2% of patients with E‐FibroMeter (accuracy: 92.9%), P < 0.001. The patient rate with 100% predictive values for cirrhosis by the best combination was twice (36.2%) that of the best single test (FibroMeter: 16.2%, P < 0.001).ConclusionThe new test combination increased: accuracy, globally and especially in patients without fibrosis, staging precision, cirrhosis prediction, and even reliability, thus offering improved fibrosis staging.
Lower Urinary Tract Symptoms are Associated with Erectile Function and Psychological Symptoms in Men with Late‐Onset Hypogonadism Syndrome
Authors: SHIGEHARA Kazuyoshi , SUGIMOTO Kazuhiro , KONAKA Hiroyuki , MAEDA Yuji , KITAGAWA Yasuhide , MIZOKAMI Atsushi , KOH Eitetsu , NAMIKI Mikio 
Published: October 2013

ObjectiveWe assessed the factors significantly associated with lower urinary tract symptoms (LUTS) in men with late‐onset hypogonadism (LOH) syndrome.MethodsThe study population consisted of 258 patients aged 40 years or older diagnosed with LOH syndrome. Each patient completed a questionnaire study, such as the International Index of Erectile Function (IIEF) 5, Aging Male Score (AMS), and International Prostate Symptom Score (IPSS). Body mass index (BMI), waist size, and muscle volume were measured in all patients, and blood biochemical data, including total cholesterol, triglyceride, hemoglobin A1c, and free testosterone (free T), were also collected. We analyzed the factors that have effect on IPSS.ResultsThe mean age of the patients was 64.9 ± 8.7 years, and the mean free T value was 7.3 ± 2.2 pg/mL. The critical factors affecting IPSS were IIEF5 score, BMI, muscle volume, age, AMS, and free T‐value (P < 0.05). Age showed the strongest significant positive correlation with IPSS (r = 0.321, P < 0.001). Each factor was controlled for age. IIEF5 score and AMS were independent factors affecting IPSS (r = −0.221 and 0.195, respectively, P < 0.05). IPSS showed an inverse correlation with IIEF5, and a positive correlation with AMS. LUTS also had a weak negative correlation with Free T‐value but this was not significant (r = −0.121, P = 0.061).ConclusionLower urinary tract symptoms were significantly correlated with erectile function and psychological symptoms in men with LOH syndrome.