bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra‐Processed Food Consumption and Risk of Incident Hypertension in US Middle‐Aged Adults
Authors: Rivera Nikolaos , Du Shutong , Bernard Lauren , Kim Hyunju , Matsushita Kunihiro , Rebholz Casey M. 
Published: August 2024

Background
Consumption of ultra‐processed food, which is manufactured food that is high in additives and sparse in intact foods, is adversely associated with cardiovascular health, primarily in non‐US study populations. We aimed to estimate the association between ultra‐processed food consumption and incident hypertension in middle‐aged adults in the United States.

Methods and Results

We included 8923 ARIC (Atherosclerosis Risk in Communities) study participants who were hypertension free at baseline and had complete dietary, covariate, and hypertension data from visit 1 (1987–1989). Over a median (25th, 75th percentile) follow‐up of 13 (6–21) years, 79% of participants developed hypertension. Participants in the highest quartile of ultra‐processed food consumption had 15% higher risk of incident hypertension than those in the lowest quartile (hazard ratio [HR], 1.15 [95% CI, 1.08–1.23]). Participants in the highest quartile of consumption of sugar‐sweetened beverages, red and processed meat, and margarine had 16% (HR, 1.16 [95% CI, 1.08–1.24]; p‐trend <0.001), 10% (HR, 1.10 [95% CI, 1.03–1.19];
P
trend = 0.005), and 6% (HR, 1.06 [95% CI, 0.99, 1.45];
P
trend = 0.045) higher risk of incident hypertension, respectively, when compared with the lowest quartiles of consumption. Each additional serving of minimally or unprocessed food was associated with a 2% lower risk of incident hypertension (HR, 0.98 [95% CI, 0.98, 0.99],
P
<0.001).

Conclusions
High consumption of ultra‐processed foods, specifically of sugar‐sweetened beverages, red and processed meat, and margarine, was associated with a higher incidence of hypertension, whereas minimally or unprocessed food consumption was associated with lower hypertension risk.
Using Machine Learning to Predict Outcomes Following Transfemoral Carotid Artery Stenting
Authors: Li Ben , Eisenberg Naomi , Beaton Derek , Lee Douglas S. , Al‐Omran Leen , Wijeysundera Duminda N. , Hussain Mohamad A. , Rotstein Ori D. , de Mestral Charles , Mamdani Muhammad , Roche‐Nagle Graham , Al‐Omran Mohammed 
Published: August 2024

Background
Transfemoral carotid artery stenting (TFCAS) carries important perioperative risks. Outcome prediction tools may help guide clinical decision‐making but remain limited. We developed machine learning algorithms that predict 1‐year stroke or death following TFCAS.

Methods and Results
The VQI (Vascular Quality Initiative) database was used to identify patients who underwent TFCAS for carotid artery stenosis between 2005 and 2024. We identified 112 features from the index hospitalization (82 preoperative [demographic/clinical], 13 intraoperative [procedural], and 17 postoperative [in‐hospital course/complications]). The primary outcome was 1‐year postprocedural stroke or death. The data were divided into training (70%) and test (30%) sets. Six machine learning models were trained using preoperative features with 10‐fold cross‐validation. The primary model evaluation metric was area under the receiver operating characteristic curve. The algorithm with the best performance was further trained using intra‐ and postoperative features. Model robustness was assessed using calibration plots and Brier scores. Overall, 35 214 patients underwent TFCAS during the study period and 3257 (9.2%) developed 1‐year stroke or death. The best preoperative prediction model was extreme gradient boosting, achieving an area under the receiver operating characteristic curve of 0.94 (95% CI, 0.93–0.95). In comparison, logistic regression had an AUROC of 0.65 (95% CI, 0.63–0.67). The extreme gradient boosting model maintained excellent performance at the intra‐ and postoperative stages, with area under the receiver operating characteristic curve values of 0.94 (95% CI, 0.93–0.95) and 0.98 (95% CI, 0.97–0.99), respectively. Calibration plots showed good agreement between predicted/observed event probabilities with Brier scores of 0.11 (preoperative), 0.11 (intraoperative), and 0.09 (postoperative).

Conclusions
Machine learning can accurately predict 1‐year stroke or death following TFCAS, performing better than logistic regression.
From Imminent Threat to Metaphor: Gog and Magog in Modern Sunnī Sources
Authors: Polinsky Sheridan 
Published: August 2024

Abstract
Gog and Magog are portrayed in the Quran as two malevolent forces that once wreaked havoc on earth and will reappear near the end of time. Hadiths elaborate their natures and actions and served as the principal source for premodern Muslim treatment of the two. In the modern period, Gog and Magog have, besides remaining objects of Quran exegesis, received considerable attention from apocalyptic writers. This article contributes to current scholarship on the modern Muslim discourse on Gog and Magog by examining the views of some notable Sunnī Quran commentators, which have thus far been almost entirely neglected. I show that they adopt either a literal interpretation, whereby Gog and Magog are understood as certain humans, or a metaphorical interpretation, whereby they are conceived as symbols of various phenomena. I also survey, in contrast to most previous researchers, the ideas of several non-Arab writers, especially the Trinidadian Imran Nazar Hosein (b. 1942), author of several apocalyptic works, including a book on Gog and Magog and their dominance in today’s world. My discussion highlights the remarkable diversity of perspectives among Muslim scholars as well as the tendency to demythologize Gog and Magog by either avoiding hadiths or understanding them in light of contemporary circumstances.
International Criminal Law, Complementarity and Amnesty Within the Context of Transitional Justice: Lessons from Uganda
Authors: Kirabira Tonny Raymond 
Published: August 2024

Abstract
The article explores the domestic implementation of international criminal law and complementarity, when operating alongside parallel transitional justice approaches. International criminal justice in Uganda is best understood as part of the broader lens of transitional justice, in response to a two-decade war in the Northern part of the country. Besides a doctrinal analysis of the relevant legal regime and cases, the article benefits from the author’s personal insights working in Uganda and The Hague, the two sites of international justice that inform this article. Specifically, the International Crimes Division (icd) which is the specialised court dealing with war crimes and crimes against humanity and the International Criminal Court (icc). The article highlights critical paradoxes of the icd and trial of former rebel Thomas Kwoyelo, putting this domesticated International Criminal Justice regime in a dilemma, also suggesting pathways for reforms.
The Response of Tropopause-Overshooting Convection over North America to Climate Change
Authors: Tinney Emily N. , Homeyer Cameron R. , Bedka Kristopher M. , Scarino Benjamin R. 
Published: August 2024

Abstract
Recent field campaigns, observational studies, and modeling work have demonstrated that extratropical tropopause-overshooting convection has a substantial and previously underestimated impact on stratospheric water vapor concentrations. This necessitates improved understanding of how tropopause-overshooting convection will respond to a warming climate. A growing body of research indicates that environments conducive to severe thunderstorms will occur more often and be increasingly unstable in the future, but no study has examined how this may be related to increased overshooting. To rectify this, this study leverages an existing pseudo–global warming (PGW) experiment to evaluate potential future changes in tropopause-overshooting convection over North America. We examine two 10-yr simulations consisting of 1) a retrospective period (2003–12) forced by ERA-Interim initial and boundary conditions (the control simulation) and 2) the same retrospective period with CMIP5 ensemble-mean high-end emission scenario climate changes added to the initial and boundary conditions (the PGW simulation). Tropopause-overshooting convection in the control simulation is validated against observed overshoots from both ground-based radar observations in the United States and GOES observations over North America. The model is shown to effectively simulate the observed regional distribution, annual cycle, and diurnal cycle of tropopause-overshooting convection. In the PGW simulation, tropopause-overshooting convection is found to increase more than 250% across the model domain, and the projected seasonal period of frequent tropopause-overshooting convection is shown to extend into late summer. Additionally, tropopause-overshooting convection with extreme tropopause-relative heights (>4 km) is more frequent in a warmed climate scenario.
Serum 25-hydroxyvitamin D levels and health outcomes of hospitalization owing to COVID-19: a retrospective cross-sectional study
Authors: Metonidze Irina , Bostoganashvili Nestan , Goderidze Tamar , Tananashvili David 
Published: August 2024

Objective We investigated the role of serum 25(OH)D (25-hydroxyvitamin D) in COVID-related health outcomes. Methods We conducted a retrospective cross-sectional study using data of the National Center of Disease Control and Public Health, Georgia. We extracted patient data including length of hospital stay, transfer to the intensive care unit, requirement for oxygen therapy, treatment with glucocorticoids, and symptoms. After obtaining written informed consent, 384 individuals were enrolled. We divided participants into three groups according to 25(OH)D levels: group 1 = 25(OH)D <12 ng/mL (n = 83), group 2 = 25(OH)D 12–20 ng/mL (n = 141), and group 3 = 25(OH)D >20 ng/mL (n = 160). Results The odds ratio (OR) for hospitalization in group 1 versus group 2 was 8.7 (95% confidence interval [CI] 3.6–21.3) and 5.6 for group 1 versus 3 (95% CI 2.7–11.9). Regarding oxygen therapy, OR = 28.41 for group 1 versus 2 (95% CI 3.7–220.5) and OR = 5.2 for group 1 versus 3 (95% CI 1.9–14.1). Regarding treatment with glucocorticoids, OR = 3.7 for group 1 versus 2 (95% CI 1.1–12.5) and OR = 8.4 for group 1 versus 3 (95% CI 1.8–40.7). Conclusion COVID-19-related morbidity was associated with decreased serum 25(OH)D levels. Future studies should investigate the potential role of vitamin D sufficiency in preventing SARS-CoV-2 infection and mortality.
Bioinformatics analysis and identification of cuproptosis-related long non-coding RNAs in colorectal cancer
Authors: Chen Weihong , Huang Dongqin , Su Xiaoping , Su Yuchao , Li Shaobin 
Published: August 2024

Objective Identifying precise biomarkers for colorectal cancer (CRC) detection and management remains challenging. Here, we developed an innovative prognostic model for CRC using cuproptosis-related long non-coding RNAs (lncRNAs). Methods In this retrospective study, CRC patient transcriptomic and clinical data were sourced from The Cancer Genome Atlas database. Cuproptosis-related lncRNAs were identified and used to develop a prognostic model, which helped categorize patients into high- and low-risk groups. The model was validated through survival analysis, risk curves, independent prognostic analysis, receiver operating characteristic curve analysis, decision curves, and nomograms. In addition, we performed various immune-related analyses. LncRNA expression levels were examined in normal human colorectal epithelial cells (FHC) and CRC cells (HCT-116) using quantitative polymerase chain reaction (qPCR). Results Six cuproptosis-related lncRNAs were identified: ZKSCAN2-DT, AL161729.4, AC016394.1, AC007128.2, AL137782.1, and AC099850.3. The prognostic model distinguished between high-/low-risk populations, demonstrating excellent predictive ability for survival outcomes. Immunocorrelation analysis showed significant differences in immune cell infiltration and functions, immune checkpoint expression, and m6A methylation-related genes. The qPCR results showed significant upregulation of ZKSCAN2-DT, AL161729.4, AC016394.1, AC007128.2 in HCT-116 cells, while AL137782.1 and AC099850.3 expression patterns were significantly downregulated. Conclusion Cuproptosis-related lncRNAs can potentially serve as reliable diagnostic and prognostic biomarkers for CRC.
Orthostatic Vital Signs After Sport-Related Concussion: A Cohort Study
Authors: Sas Andrew R. , Popovich Michael J. , Gillenkirk Aleah , Greer Cindy , Grant John , Almeida Andrea , Ichesco Ingrid K. , Lorincz Matthew T. , Eckner James T. 
Published: August 2024

Background: The 6th International Consensus Statement on Concussion in Sport guidelines identified that measuring autonomic nervous system dysfunction using orthostatic vital signs (VSs) is an important part of the clinical evaluation; however, there are limited data on the frequency of autonomic nervous system dysfunction captured via orthostatic VSs after concussion. Purpose: To compare orthostatic changes in heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) between athletes with acute sport-related concussion (SRC) and control athletes. Study Design: Cross-sectional study; Level of evidence, 3. Methods: We compared 133 athletes (mean age, 15.3 years; age range, 8-28 years; 45.9% female) with acute SRC (<30 days after injury) with 100 control athletes (mean age, 15.7 years; age range, 10-28 years; 54.0% female). Given the broad age range eligible for study inclusion, participants were subdivided into child (younger than 13 years of age), adolescent (13-17 years of age), and adult (18 years of age and older) age groups for subanalyses. Participants completed a single standard orthostatic VS evaluation including HR, SBP, and DBP in the supine position then immediately and 2 minutes after standing. Linear regression was used to compare delayed supine-to-standing changes in HR, SBP, and DBP as a continuous variable (ΔHR, ΔSPB, and ΔDBP) between groups, and logistic regression was used to compare patients with positive orthostatic VS changes (sustained HR increase ≥30 beats per minute [bpm], SBP decrease ≥20 mm Hg, and DBP ≥10 mm Hg at 2 minutes) between groups, accounting for age and sex. Results: Between-group differences were present for delayed ΔHR (18.4 ± 12.7 bpm in patients with SRC vs 13.2 ± 11.0 bpm in controls; P = .002) and ΔSPB (–3.1 ± 6.6 bpm in patients with SRC vs –0.4 ± 6.5 bpm in controls; P = .001), with positive orthostatic HR changes present more frequently in patients with SRC (18% vs 7%; odds ratio, 2.79; P = .027). In the SRC group, a weak inverse relationship was present between age and ΔHR ( r = –0.171; P = .049), with positive orthostatic HR findings occurring primarily in the child and adolescent SRC subgroups. Conclusion: Patients with acute SRC had greater orthostatic VS changes compared with controls, the most prominent being sustained HR elevations. Clinical evaluation of autonomic change after SRC via standard orthostatic VS assessment may be a helpful clinical biomarker in the assessment of SRC, especially in children and adolescents.
Investigations into rubbing wear behavior of honeycomb land against labyrinth fin with periodic-cell model
Authors: Yan Xin , Wang Haibo , He Kun 
Published: August 2024

The periodic-cell model was proposed to simulate the successive contacts between the labyrinth fin and multiple honeycomb cells. With the experimental data, the finite-element-analysis (FEA) method with the periodic-cell model was validated. The effects of incursion parameters (i.e. incursion depth, incursion rate and sliding velocity) on the contact force, frictional temperature, material loss, and worn geometry of the honeycomb seal during the incursion process were studied. With the predicted worn geometry, the sealing performance degradation in the honeycomb seal was analyzed. The results showed that the proposed periodic-cell model has an excellent accuracy in predicting the wear behavior of honeycomb seal in rubbing events. The contact force between the honeycomb liner and labyrinth fin is pronounced especially at low sliding velocity and high incursion rate conditions, which increases the possibility of wear damage in the rotor part. At low sliding velocity and low incursion rate conditions, the frictional heat transferring to rotor part is increased, which increases the thermal stress near the contact region of the rotor part. As the clearance gap of honeycomb seal increases from 0.6 mm to 0.9 mm in the rubbing event, the leakage rate is increased by about 12%, and the carry-over effects downstream of the worn cells are increased.
Withdrawal pain following patients discontinuing Trk inhibitors
Authors: Chin Alan , Lindsay Sheila , Bergsland Emily K , Kang Hyunseok 
Published: August 2024

Objective This article aims to expand on the existing literature regarding the incidence of withdrawal pain following discontinuation of Trk inhibitors and to explore strategies that mitigate this withdrawal pain. Data Source A retrospective observational study was conducted among patients who were at least 18 years-old or older and had documentation of starting larotrectinib or entrectinib at University of California, San Francisco (UCSF) between November 2018 and November 2022. Data were collected from electronic records and pharmacy databases and a total of 21 patients were identified in this study. Data Summary Of the 21 patients included in this study, five patients (24%) experienced pain during temporary or permanent discontinuation of Trk inhibitor with the onset of withdrawal pain ranging from a few hours to three days following discontinuation. Various strategies were implemented to manage this pain including restarting of Trk inhibitor, tapering of Trk inhibitor on discontinuation, minimizing dose interruptions and use of prescription pain medications. Conclusion This article illustrates the presence of withdrawal pain syndrome in patients stopping a Trk inhibitor treatment and highlight the need for patient education to avoid missing any doses and for development of a guideline for Trk inhibitor discontinuation.
Diagnostic value of soluble Interleukin-2 receptor in patients suffering neurosarcoidosis: A systematic review
Authors: Chanpura Aditya , Gupta Rajesh K. , Sriwastava Shitiz K. , Rahmig Jan 
Published: August 2024

Background Neurosarcoidosis is an inflammatory granulomatous disease. Up to 25% of occult sarcoidosis affecting the nervous system are only detected by autopsy. In addition, in recent years the suspicion arose that the soluble Interleukin-2 Receptor (sIL-2R) might be useful in differentiating between neurosarcoidosis and neurosarcoidosis-like diseases such as neurotuberculosis, multiple sclerosis, or cerebral lymphoma. Objectives Therefore, we aimed to systematically review randomized controlled trials (RCT), observational studies, and case-control studies evaluating sIL-2R levels in neurosarcoidosis patients. Design For this systematic review, a comprehensive literature search of electronic databases including EMBASE, The Web Of Science, The Cochrane Library, MEDLINE, and Google Scholar was conducted. The search was limited to the English language and publication date up to January 08th, 2024. Data Sources and Methods As part of the search strategy conducted, 6 articles met the inclusion criteria. Two independent reviewers extracted the relevant data from each article. In addition, 2 independent reviewers assessed the quality of each study using the Newcastle-Ottawa Scale (NOS). Results We included 6 studies comprising 98 patients suffering from neurosarcoidosis, 525 non-sarcoidosis patients, and 118 healthy controls. Included studies were published between 2010 and 2023. Cerebrospinal fluid (CSF) sIL-2R levels differed significantly between neurosarcoidosis patients and multiple sclerosis, vasculitis, and healthy controls whereas serum sIL-2R levels did not reveal sufficient discriminative power. sIL-2R index was able to discriminate neurosarcoidosis from neurotuberculosis, bacterial/viral meningitis, and healthy controls. Conclusions In this systematic review, we found indications that sIL-2R may be a useful biomarker for the diagnosis of neurosarcoidosis. To determine an additional diagnostic value of sIL-2R, large prospective studies are needed that not only examine absolute sIL-2R levels in serum or CSF but also the dynamic changes as well as the implications of renal function on sIL-2R levels.
Association of Vitamin D Deficiency With Distal Biceps Injury: A Retrospective Analysis of 336,320 Patients
Authors: Khatri Surya , Albright J. Alex , Byrne Rory A. , Quinn Matthew , Zhu Angela S. , Arcand Paul-Hugo , Daniels Alan H. , Owens Brett D. 
Published: August 2024

Background: This study explores the association between vitamin D deficiency and distal biceps tendon injuries, illustrating that, although vitamin D deficiency is associated with prolonged hospital stays and various musculoskeletal problems, its connection to distal biceps tendon injuries is unknown. Hypothesis: Vitamin D deficiency is associated with an elevated risk of distal biceps injury but not with increased rates of subsequent surgery or revision surgery. Study Design: Case-control study. Level of Evidence: Level 3. Methods: A 1:1 matched retrospective comparative study of 336,320 vitamin-D-deficient patients was performed using PearlDiver data (between January 1, 2011 and October 31, 2018). Cohorts, with a mean age of 55.7 ± 13.2 years, underwent multivariate logistic regression to calculate distal biceps tendon injury and surgical repair incidence according to age and sex, while controlling for demographics and comorbidities. Results: The 1-year incidence of distal biceps tendinopathy in vitamin-D-deficient patients was 118 per 100,000 person-years (95% CI) compared with 44.3 per 100,000 person-years in matched controls. Male patients with vitamin D deficiency were at a greater risk for distal biceps tendinopathy after 1 and 2 years (adjusted odds ratio [aOR] = 2.81, 2.08-3.83; aOR = 2.80, 2.21-3.56). Female patients were also at a greater risk after both years (aOR = 1.69, 1.27-2.27; aOR = 1.57, 1.26-1.96). Vitamin D deficiency was not associated with an elevated risk of surgical repair or revision surgery. Conclusion: In a nationwide cohort, a diagnosis of vitamin D deficiency elevated the risk of distal biceps tendinopathy but did not raise the rate of surgical repair or revision. As a result, prevention strategies in the form of vitamin supplementation should be increased for athletes. Clinical Relevance: These findings emphasize the clinical relevance of monitoring vitamin D levels in patients at risk for musculoskeletal injuries, and providing adequate care to those involved in high-demand physical activities. Strength of Recommendation: B.