bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking Instructional Improvement For Multilingual Learners
Authors: Claudet Joseph G. 
Published: July 2024

Instructional leaders in many K-12 school districts in the United States are facing increasingly difficult challenges associated with providing for the academic development and support needs of the growing numbers of culturally and linguistically diverse students populating their elementary and secondary school classrooms. This article highlights the comprehensive design-based instructional improvement efforts of one high school principal and his intervention task force colleagues working in a high diversity metropolitan school district. The article’s case study showcases how the high school’s instructional improvement leaders utilized multileveled data analysis investigative techniques in conjunction with innovative professional development design strategies derived from the education improvement science literature to develop and implement a comprehensive professional learning intervention program for multiple grade-level teams of core content area teachers and Spanish heritage language teachers. Intervention program implementation efforts focused specifically on: 1) assisting educators in critically examining their own deficit thinking attitudes and instructional planning mindsets regarding the perceived learning capabilities of students learning English as a second language; and 2) jumpstarting these educators’ biliteracy-centered instructional planning and teaching practices to address the unique multilingual academic development needs of the campus’s large population of immigrant/emergent bilingual and other diverse learners. The article concludes with a literature-based discussion of the positive instructional improvement benefits that can accrue to both teachers and students through leveraging multileveled analytic thinking along with design-based intervention program development strategies to significantly expand learning opportunities for culturally and linguistically diverse students.
Comprehensive analysis of cutaneous adverse drug reactions during hospitalization: unveiling nuanced complexities and ensuring patient safety
Authors: Ahangar Junaid Ahmad , Semira  , Qayoom Seema , Bhat Mudasir Shafi 
Published: July 2024

Background: The spectrum of cutaneous drug reactions encompasses a broad range from benign rashes to potentially life-threatening conditions. The present study aims to comprehensively investigate the frequency, type, causality, preventability, and severity of adverse drug reactions (CADRs) occurring during hospitalization. Methods: Conducted at SKIMS Medical College Hospital over a comprehensive six-month duration, this study systematically monitored the occurrence of cutaneous drug reactions. These reactions' causality, severity, and preventability assessments were meticulously conducted using established classifications such as the Wills and Brown classification, WHO criteria, Hartwig scale, and modified Schumock and Thornton scales. Result and discussion: Involving a cohort of 300 admissions, the study identified an incidence of adverse drug reactions (CADRs) at 8%. Detailed analysis revealed no significant associations between CADRs and gender, drug allergy history, or the number of drugs administered. Notably, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), particularly Dapsone, emerged as the most common drug class associated with cutaneous adverse drug reactions (CADRs), accounting for 41.67% of cases. Antibiotics, including linezolid (12.5%) and amikacin (12.5%), followed closely. Itching (37.5%), followed by red raised lesions (33.33%), emerged as the predominant reported reactions, showcasing associations with various drugs. Notably, a significant proportion of CADRs were categorized as mild (50%), with 95.83% deemed not preventable. Conclusion: The prevalence of mild reactions, particularly linked to NSAIDs and antibiotics, underscores the nuanced complexities in drug responses. The research enriches the broader comprehension of adverse drug reactions, underscoring the imperative for meticulous surveillance and scholarly inquiry to elevate patient safety.
Las series de ficción histórica en Chile y su impacto en la recuperación de la memoria en las redes sociales de Internet. El caso de Los 80: más que una moda y Los Archivos del Cardenal.
Authors: Chamorro Maldonado Miguel 
Published: July 2024

El momento que viven las series de ficción televisivas es auspicioso gracias a su calidad técnica, profesional y temática. Un ejemplo de ello son las ficciones con contenido histórico. Su producción no sólo involucra proyectar la obra por la pantalla chica, sino además realizar un trabajo benéfico a través de la distribución de sus contenidos en las redes sociales, generando un contacto activo de comunicación de múltiples mensajes, donde los usuarios opinan sobre el tratamiento temático y escénico. La presente comunicación es un estudio de la relación que hacen los usuarios en las plataformas digitales sobre la memoria histórica en entornos digitales. La muestra corresponde a las redes sociales asociadas a las series cuyo argumento se enmarca en periodos pasados de la historia reciente de Chile, es decir, a la dictadura militar caracterizada por una crisis social y política reflejado en sus series televisivas, Los 80: más que una moda y Los Archivos del Cardenal.El artículo es el resultado de una investigación iniciado el año 2012, proyecto financiado por la Comisión Nacional de Investigación Científica y Tecnológica de Chile con su programa Capital Humano Avanzado, Becas Chile, del Ministerio de Educación.El estudio busca comprender el sentido del recuerdo, desde la perspectiva de los usuarios con el uso de un lenguaje que comunica al momento de visionar las series de ficción, teniendo presente los componentes afectivos, expresivos y de representación que señalan los participantes en las redes sociales como resultado de una comunicación en el contexto social de la memoria de Chile durante la dictadura militar.
La transparencia del Partido Popular y Ciudadanos en las campañas electorales de 2015 y 2016
Authors: Díez-Garrido María 
Published: July 2024

La sociedad digital demanda una mayor transparencia institucional y política, influida por la apertura y accesibilidad características de Internet. La campaña electoral es la época para que los partidos políticos demuestren de qué forma quieren actuar en el Gobierno. Este trabajo de investigación pretende analizar qué dicen los partidos sobre su compromiso con la transparencia y cuán transparentes son, en realidad, durante la campaña electoral. Así, pretende medir el nivel transparencia del Partido Popular y Ciudadanos durante las campañas electorales de 2015 y 2016 para las Elecciones Generales. El estudio se realizó teniendo en cuenta lo que estos partidos dicen sobre la transparencia en sus programas electorales. A continuación, se estudió cómo lo trasladan a la realidad estas ideas en sus respectivos portales de transparencia. Para ello, se abordó un análisis de contenido cuantitativo y semi-cualitativo a partir del proyecto de Dader, Campos y Quintana (2011) que la transparencia de organización, la transparencia de la actividad de campaña, la transparencia de la participación con los ciudadanos, la transparencia de datos y de instrumental informático y el portal de transparencia. Los resultados permiten observar las diferencias entre aquello que proclaman en sus programas electorales y la realidad de sus portales de transparencia
Monochorionic Twin Pregnancy with Hydranencephaly and Co-Twin Death: A Case Report
Authors: Baidi H. , Sellouti M. , Ayad A. , Abilkassem R. 
Published: July 2024

Background: Hydranencephaly is a rare congenital brain malformation with an incidence estimated to be between 1 in 10 000 and 1 in 5 000 pregnancies. It is characterized by the absence of development of the cerebral hemispheres, which are replaced by cerebrospinal fluid. The diagnosis of hydranencephaly can be made from 15 weeks of amenorrhea via obstetric ultrasound, with antenatal nuclear MRI being the definitive test to establish the diagnosis. The condition results from an anomaly in embryogenesis after the formation of the neural plate, though the exact pathophysiology of hydranencephaly is not yet clear. There is no definitive treatment for hydranencephaly; treatment is symptomatic and supportive. The prognosis for children with hydranencephaly is generally poor, with death usually occurring within the first year of life.
Methods: We conducted a thorough clinical examination and neurological assessment. Imaging studies (CT, MRI) confirmed the diagnosis of hydranencephaly. Data were collected from medical records and interviews with the patient’s parents.
Results: We report a case of a female newborn, from a monochorionic twin pregnancy with an in utero fetal death of her twin, admitted for the exploration of congenital hydrocephalus and intrauterine growth restriction (IUGR) detected on prenatal ultrasound. Clinically, she had microcephaly, and postnatal imaging revealed hydranencephaly.
Conclusion and Recommendations: Hydranencephaly is a rare and serious malformation of the nervous system with a guarded prognosis. The etiopathogenesis is still poorly understood. During the antenatal period, it is important to discuss the possibility of medical termination of pregnancy if feasible. Otherwise, cephalocentesis might be considered to avoid a cesarean section. It is crucial to distinguish this condition, which has a poor prognosis, from extensive hydrocephalus, which has the potential for an improved prognosis with early shunting procedures.
Global warming releases microplastic legacy frozen in Arctic Sea ice
Authors: Obbard Rachel W. , Sadri Saeed , Wong Ying Qi , Khitun Alexandra A. , Baker Ian , Thompson Richard C. 
Published: May 2014

AbstractWhen sea ice forms it scavenges and concentrates particulates from the water column, which then become trapped until the ice melts. In recent years, melting has led to record lows in Arctic Sea ice extent, the most recent in September 2012. Global climate models, such as that of Gregory et al. (2002), suggest that the decline in Arctic Sea ice volume (3.4% per decade) will actually exceed the decline in sea ice extent, something that Laxon et al. (2013) have shown supported by satellite data. The extent to which melting ice could release anthropogenic particulates back to the open ocean has not yet been examined. Here we show that Arctic Sea ice from remote locations contains concentrations of microplastics are several orders of magnitude greater than those that have been previously reported in highly contaminated surface waters, such as those of the Pacific Gyre. Our findings indicate that microplastics have accumulated far from population centers and that polar sea ice represents a major historic global sink of man‐made particulates. The potential for substantial quantities of legacy microplastic contamination to be released to the ocean as the ice melts therefore needs to be evaluated, as do the physical and toxicological effects of plastics on marine life.
Chronic neutrophilic leukemia 2014: Update on diagnosis, molecular genetics, and management
Authors: Elliott Michelle A. , Tefferi Ayalew 
Published: May 2014

Disease Overview: Chronic neutrophilic leukemia (CNL) is a myeloproliferative neoplasm characterized by sustained, mature neutrophilic leukocytosis, splenomegaly, and bone marrow granulocytic hyperplasia. Diagnosis: Key diagnostic criteria include leukocytosis of >25 × 109/l (of which >80% are neutrophils) with <10% and <1% circulating immature granulocytes and myeloblasts, respectively. There should be no dysplasia, monocytosis, molecular evidence of BCR‐ABL1, PDGFRA, PDGFRB, or FGRF1 rearrangements and no identifiable cause for physiologic neutrophilia or, if present, demonstration of myeloid clonality. Developments in Molecular Genetics: Recently, CNL has been shown to be specifically driven by somatic activating mutations of CSF3R, most commonly CSF3R T618I. As such, the diagnosis of CNL will no longer be one of exclusion only, and revision of the current WHO classification is anticipated to include the molecular criterion of mutated CSF3R. Am. J. Hematol. 89:651–658, 2014. © 2014 Wiley Periodicals, Inc.
Conservative versus invasive treatment of primary spontaneous pneumothorax: a retrospective cohort study
Authors: Chew Rusheng , Gerhardy Benjamin , Simpson Graham 
Published: May 2014

AimThe best management of primary spontaneous pneumothorax is unclear. Conservative treatment has been proposed, but no studies comparing conservative with invasive management have been carried out where pneumothorax size has been numerically quantified. This study aimed to evaluate the feasibility of conservative management for primary spontaneous pneumothoraces of any size.MethodsRetrospective cohort study of adult patients with primary spontaneous pneumothorax treated at an Australian tertiary hospital from 2006–2011, carried out by case‐note and chest radiograph review. Patient demographics, smoking status, and outcome data were collected. Pneumothorax size was calculated using the Collins method, based on the sum of interpleural distances.ResultsOne hundred and twenty‐seven episodes from 116 patients were identified. Males (86) comprised 75% of patients, and the median age at presentation was 37 years. Eighty‐two percent of cases (106) were ever‐smokers. Of the episodes in which pre‐treatment radiographs were available, 53 were treated conservatively and 58 invasively with tube thoracostomy, and all were clinically stable. When cases were stratified by pneumothorax size, age, sex, ethnicity, and smoking status had no effect on outcome. Compared to invasive treatment, conservative management resulted in no complications, an equal recurrence rate, and a significantly shorter length of stay.ConclusionsOur results suggest that it may be feasible to adopt a conservative approach as the first‐line treatment of primary spontaneous pneumothorax in clinically stable patients. However, given the limitations of this study, a large randomised controlled trial is required to conclusively prove this assertion.
Nickel‐Catalyzed α‐Arylation of Ketones with Phenol Derivatives
Authors: Takise Ryosuke , Muto Kei , Yamaguchi Junichiro , Itami Kenichiro 
Published: May 2014

AbstractThe nickel‐catalyzed α‐arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α‐arylketones. For this transformation, 3,4‐bis(dicyclohexylphosphino)thiophene (dcypt) was identified as a new, enabling, air‐stable ligand for this transformation. The intermediate of an assumed CO oxidative addition was isolated and characterized by X‐ray crystal‐structure analysis.
Carbon Nanotubes Decorated with CoP Nanocrystals: A Highly Active Non‐Noble‐Metal Nanohybrid Electrocatalyst for Hydrogen Evolution
Authors: Liu Qian , Tian Jingqi , Cui Wei , Jiang Ping , Cheng Ningyan , Asiri Abdullah M. , Sun Xuping 
Published: May 2014

AbstractThe development of effective and inexpensive hydrogen evolution reaction (HER) electrocatalysts for future renewable energy systems is highly desired. The strongly acidic conditions in proton exchange membranes create a need for acid‐stable HER catalysts. A nanohybrid that consists of carbon nanotubes decorated with CoP nanocrystals (CoP/CNT) was prepared by the low‐temperature phosphidation of a Co3O4/CNT precursor. As a novel non‐noble‐metal HER catalyst operating in acidic electrolytes, the nanohybrid exhibits an onset overpotential of as low as 40 mV, a Tafel slope of 54 mV dec−1, an exchange current density of 0.13 mA cm−2, and a Faradaic efficiency of nearly 100 %. This catalyst maintains its catalytic activity for at least 18 hours and only requires overpotentials of 70 and 122 mV to attain current densities of 2 and 10 mA cm−2, respectively.
Heptagon‐Embedded Pentacene: Synthesis, Structures, and Thin‐Film Transistors of Dibenzo[d,d′]benzo[1,2‐a:4,5‐a′]dicycloheptenes
Authors: Yang Xuejin , Liu Danqing , Miao Qian 
Published: May 2014

AbstractThis study presents a new class of conjugated polycyclic molecules that contain seven‐membered rings, detailing their synthesis, crystal structures and semiconductor properties. These molecules have a nearly flat C6‐C7‐C6‐C7‐C6 polycyclic framework with a p‐quinodimethane core. With field‐effect mobilities of up to 0.76 cm2 V−1 s−1 as measured from solution‐processed thin‐film transistors, these molecules are alternatives to the well‐studied pentacene analogues for applications in organic electronic devices.
Selenium–Platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a Reactive Oxygen Species (ROS)‐Mediated Apoptosis Route
Authors: Zeng Lingwu , Li Yang , Li Tianyu , Cao Wei , Yi Yu , Geng Weijia , Sun Zhiwei , Xu Huaping 
Published: May 2014

AbstractWe report the preparation of selenium‐containing platinum‐based anticancer drug EG‐Se/Pt. EG‐Se/Pt was obtained from the coordination of selenium‐containing molecules (EG‐Se) with cisplatin (CDDP). The structure of EG‐Se/Pt was characterized by 1H and 77Se NMR spectroscopy, XPS, ESI‐MS, and MALDI‐TOF. In aqueous solution, EG‐Se/Pt self‐assembles to form spherical aggregates. EG‐Se/Pt shows enhanced stability against dilution and high salt concentration compared with EG‐Se. EG‐Se/Pt induces cell apoptosis via reactive oxygen species (ROS), which leads to high selectivity between cancer cells and normal cells in cytotoxicity assays. More importantly, EG‐Se/Pt effectively inhibits tumor growth in vivo in tumor‐bearing mice. It is anticipated that tuning the ROS level through the assembly of selenium‐containing molecules can be a general method to realize anticancer selectivity.
Suppression of stromal interaction molecule 1 inhibits SMMC7721 hepatocellular carcinoma cell proliferation by inducing cell cycle arrest
Authors: Wu Zhengshan , Qing Jiangjie , Xia Yongxiang , Wang Ke , Zhang Feng 
Published: May 2014

AbstractStromal interaction molecule 1 (STIM1), an endoplasmic reticulum luminal Ca2+ sensor, activates Ca2+‐release‐activated Ca2+ channels and migrates from the Ca2+ store to the plasma membrane. Recently, STIM1 was shown be critical for the progression of several cancers, including breast cancer and cervical cancer. However, its role in hepatocellular carcinoma has remained unknown. The current study was aimed to evaluate the effect of STIM1 on the growth of hepatocellular cancer. Lentivirus‐mediated short hairpin RNA targeting STIM1 was transduced into SMMC7721 cells to knock down STIM1 expression. Knockdown of STIM1 significantly inhibited cell proliferation and colony‐forming ability and arrested the cell cycle at the G0/G1 phase. Moreover, the DNA synthesis progression was also decreased. Furthermore, lentiviral vector‐mediated overexpression of STIM1 promoted the proliferation of SMMC7721 cells. Our findings suggest that STIM1 may play an important role in the development of hepatocellular cancer and may be a potential target for therapy.
Challenges in industrial fermentation technology research
Authors: Formenti Luca Riccardo , Nørregaard Anders , Bolic Andrijana , Hernandez Daniela Quintanilla , Hagemann Timo , Heins Anna‐Lena , Larsson Hilde , Mears Lisa , Mauricio‐Iglesias Miguel , Krühne Ulrich , Gernaey Krist V. 
Published: May 2014

AbstractIndustrial fermentation processes are increasingly popular, and are considered an important technological asset for reducing our dependence on chemicals and products produced from fossil fuels. However, despite their increasing popularity, fermentation processes have not yet reached the same maturity as traditional chemical processes, particularly when it comes to using engineering tools such as mathematical models and optimization techniques. This perspective starts with a brief overview of these engineering tools. However, the main focus is on a description of some of the most important engineering challenges: scaling up and scaling down fermentation processes, the influence of morphology on broth rheology and mass transfer, and establishing novel sensors to measure and control insightful process parameters. The greatest emphasis is on the challenges posed by filamentous fungi, because of their wide applications as cell factories and therefore their relevance in a White Biotechnology context. Computational fluid dynamics (CFD) is introduced as a promising tool that can be used to support the scaling up and scaling down of bioreactors, and for studying mixing and the potential occurrence of gradients in a tank.
Generative topographic mapping of binding pocket of β2 receptor and three‐way partial least squares modeling of inhibitory activities
Authors: Hasegawa Kiyoshi , Funatsu Kimito 
Published: May 2014

The visualization and characterization of protein pockets is the starting point for many structure‐based drug design projects. The size and shape of protein pockets dictate 3D geometry of ligands that can strongly inhibit the following biological events. Thus, a minimal requirement for inhibition is that a molecule sterically binds the active site with some allowance for induced fit. Methods for direct display of active sites in a protein have become prevalent in recent years.In this study, a new mapping method, generative topographic mapping, is investigated to describe the 3D surface of protein pocket. The β2 receptor protein is used as a benchmark. By mapping the molecular surface points and assigning the associated molecular electrostatic potential (MEP) values, the original 3D structure of the active site is well reproduced by the 2D latent map in generative topographic mapping. The distributions of MEP values of two 2D latent maps derived from the inhibitor and the β2 receptor protein are well complemented. Using three‐way partial least squares modeling, a predictive model linking the inhibitory activity and their MEP values can be constructed, which was not feasible in the previous spherical self‐organizing map studies. The resulting regression coefficient matrix of the three‐way partial least squares model has many insights for understanding the structural requirements for β2 inhibitory activity. Copyright © 2014 John Wiley & Sons, Ltd.
Analysis of Effects of Berberine on the Photosynthesis of Microcystis aeruginosa at Gene Transcriptional Level
Authors: Bi Xiangdong , Zhang Shulin , Dai Wei , Xing Kezhi , Pang Yue , Zhang Dajuan 
Published: May 2014

AbstractMicrocystis aeruginosa has great competition advantages to survive, grow, and dominate phytoplankton communities for its high photosynthetic activity in unsuitable conditions. Berberine was the allelochemical capable of inhibiting M. aeruginosa growth. To better understand the allelopathic mechanism involved, RNA‐sequencing technology was used to investigate the berberine‐induced changes in photosynthesis gene expression of M. aeruginosa. Using the next‐generation sequencing platform Illumina/Solexa, a total of 13 099 868 and 13 870 448 90‐bp pair‐end reads for “no berberine” and “berberine” libraries were obtained, respectively. Among these genes, 10 324 794 (no berberine) and 8 944 254 (berberine) reads mapped multiply in the genome, while 9 988 318 (no berberine) and 8 316 668 (berberine) mapped to unique targets, respectively. It was indicated that berberine significantly repressed the expression of 869 genes and induced the expression of 1419 genes. Those berberine‐affected genes belonged to different functional categories, especially enriched in various photosynthesis‐relevant metabolic pathways based on the analysis of gene ontology, clusters of orthologous group terms, and Kyoto Encyclopedia of Genes and Genomes. The results suggested that berberine‐induced disturbance in the algal photosynthesis process via repressing the expression of key photosynthesis genes, such as psbD, psaA, psaB, might be one of the main mechanisms involved in inhibitory allelopathic activity of berberine.