bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell–Mediated Control of T Cell Immunity
Authors: Cimen Bozkus Cansu , Elzey Bennett D. , Crist Scott A. , Ellies Lesley G. , Ratliff Timothy L. 
Published: October 2015

Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells that expand during benign and cancer-associated inflammation and are characterized by their ability to inhibit T cell immunity. Increased metabolism of l-Arginine (l-Arg), through the enzymes arginase 1 and NO synthase 2 (NOS2), is well documented as a major MDSC suppressive mechanism. Therefore, we hypothesized that restricting MDSC uptake of l-Arg is a critical control point to modulate their suppressor activity. Using murine models of prostate-specific inflammation and cancer, we have identified the mechanisms by which extracellular l-Arg is transported into MDSCs. We have shown that MDSCs recruited to localized inflammation and tumor sites upregulate cationic amino acid transporter 2 (Cat2), coordinately with Arg1 and Nos2. Cat2 expression is not induced in MDSCs in peripheral organs. CAT2 contributes to the transport of l-Arg in MDSCs and is an important regulator of MDSC suppressive function. MDSCs that lack CAT2 have significantly reduced suppressive ability ex vivo and display impaired capacity for regulating T cell responses in vivo as evidenced by increased T cell expansion and decreased tumor growth in Cat2−/− mice. The abrogation of suppressive function is due to low intracellular l-Arg levels, which leads to the impaired ability of NOS2 to catalyze l-Arg–dependent metabolic processes. Together, these findings demonstrate that CAT2 modulates MDSC function. In the absence of CAT2, MDSCs display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.
Refiguring the South Asian American Tradition Bearer: Performing the "Third Gender" in Yoni Ki Baat
Authors: Émon Ayeshah , Garlough Christine 
Published: October 2015

Abstract
In recent years, a growing group of scholars has begun to draw upon queer theory as they research aspects of LGBTQ folk performances and texts from around the globe. In the process, folklore scholars have become increasingly intrigued by bodies that appear to transgress dimorphism, and complicate binary oppositions like male/female. Performances of gender identity and sexuality by hijras in South Asia have awakened audiences’ imaginings since the Kama Sutra period (Gupta 2005:180). In folktale, dance, song, religious epic, and popular culture, the figure of the hijra often evokes a liminal play of "otherness." Commonly known as the "third gender"--a conceptual space outside of typical Western constructs--hijra individuals engage with varied notions of transsexual, transgender, intersex, cross-dresser, eunuch, or sexual fluidity. This article focuses on a feminist appropriation of the hijra within Yoni Ki Baat, a South Asian American version of The Vagina Monologues. The authors explore how the figure of the hijra--drawn from South Asian folk narratives, religious discourse, and popular culture--might be used strategically by social activists in political performance narratives to (1) encourage a complicated sense of sexually ambiguous or queer practices and identities, and (2) acknowledge individuals facing social oppression due to their marginalized identities. As such, their approach conceptualizes performance as both a relational space and as a space in which to wonder about questions of relationality (Madison and Hamera 2006; Schechner 1990).
From Rebounds to Three-Pointers: Linsanity, Racial Insults, and Stereotypes in Flux
Authors: Magat Margaret 
Published: October 2015

Abstract
In February 2012, a Taiwanese American point guard player for the New York Knicks, Jeremy Lin, bounded into the imagination of the nation and was embraced by basketball fans who have long rooted for the underdog. His presence in the National Basketball Association has sparked an invaluable discussion involving insider/outsider folklore, cultural politics, and stereotypes. Using Lin’s "Linderella" story and accompanying deluge of Lin-generated folk speech and behavior, this paper investigates how "Linsanity" is a pivotal event from which one can examine the continuing prevalence of racist folklore about Asian Americans while exploring the cultural shifts that are occurring.
Residential Construction Sustainability in the UK and Prospects of Knowledge Transfer to Kazakhstan
Authors: Tokbolat Serik , Kaur Calay Rajnish 
Published: October 2015

<p>This paper aimed to investigate the up-to-date levels of sustainability in the UK construction with special interest to sustainable housing. It also aims to examine the justification behind construction and housing sustainability, and to look at the practicality of transferring current expertise within the UK as well as to an emerging Central Asian country such as Kazakhstan. A synergy of case studies, survey and numerical simulation research methodologies were applied to undertake a wide-spectrum analysis of the topic. Regardless of difficulties related to applying sustainable practices the considered housing developments are found to be satisfactory in terms of environmental and socio-economic effects. Technical evaluation of the case studies compared to standard housing parameters has shown encouraging outcomes and confirmed the claimed energy and water efficiency. Findings of the survey indicated that construction companies of the UK and Kazakhstan are at different stages of application of sustainability measures. It was also established that companies and public are mainly optimistic about sustainability if suitable economical and legal conditions are ensured. Finally, numerical simulations have shown that selected sustainability measures made the studied housing projects competitive on the sustainability market. </p>
Mindfulness and Sustainability: Utilizing the Tourism Context
Authors: Lengyel Attila 
Published: October 2015

<p>After several decades of sustainability efforts humanity is still on track to worst-case climate scenario. Other planetary boundaries have also been transgressed. The symptoms point to a root cause termed by many as a crisis of perception and value system. Our consumption-oriented world view is unsustainable. What can catalyze a perceptual paradigm shift needed to avoid global socio-ecological collapse in the long-run? Besides its manifold beneficial effects tested clinically, mindfulness has been found to be positively correlated with sustainable behavior. The article gives a theoretical grounding of mindfulness highlighting some new aspects and argues that the tourism context serves as an exceptionally suitable medium for learning mindfulness techniques. Expanding on earlier openness to new experience and Google Trends research of the author it is demonstrated that tourists have a markedly raised level of openness to new experience and also that there is a strong demand side business case for developing more mindfulness-based tourism products both globally and specifically for Hungary. The study provides further evidence of the short fade-out period of positive vacation effects and shows what type of destinations and accommodations potential wellness and ecotourists consider best for learning mindfulness. </p>
Publicatie van de jaarrekening op grond van het effectenrecht: effectieve openbaarmaking of (slechts) verregaand transparant?
Authors: Hijink J.B.S. 
Published: October 2015

Publicatie van de jaarrekening op grond van het effectenrecht: effectieve openbaarmaking of (slechts) verregaand transparant?
In deze bijdrage staat centraal het arrest van het Gerechtshof ’s-Hertogenbosch waarin is uitgemaakt dat met het voldoen aan effectenrechtelijke publicatieverplichtingen ook is voldaan aan de publicatieplicht op grond van Boek 2 BW. Tegen de achtergrond van de uiteenlopend vormgegeven publicatieverplichtingen in het vennootschapsrecht enerzijds en het effectenrecht anderzijds, plaatst de auteur daarbij enige kanttekeningen.
Aansprakelijkheid voor het boedeltekort en de publicatieplicht: wat is te laat deponeren?
Authors: van Hooff J.E.P.A. 
Published: October 2015

Aansprakelijkheid voor het boedeltekort en de publicatieplicht: wat is te laat deponeren?
Voor jaarrekeningen die zien op boekjaren die starten op of na 1 januari 2016 gaat de maximale publicatietermijn van dertien naar twaalf maanden. Deze maximale termijn is de enige relevante termijn in het kader van artikel 2:248 BW. Ook bij vereenvoudigde vaststelling van de jaarrekening op grond van artikel 2:210 lid 5 BW.
Het informeren van crediteuren als verweer tegen Beklamel-aansprakelijkheid
Authors: Mussche M. 
Published: October 2015

Het informeren van crediteuren als verweer tegen Beklamel-aansprakelijkheid
De crediteur die ten tijde van het aangaan van een verbintenis met een vennootschap de financiële situatie van zijn contractuele wederpartij kende, kan de bestuurder van de vennootschap later niet succesvol aansprakelijk stellen wegens schending van de Beklamel-norm.
Geen pauliana? Gelukkig hebben we de onrechtmatige daad nog …
Authors: Beckers J.H.L. 
Published: October 2015

Geen pauliana? Gelukkig hebben we de onrechtmatige daad nog … Commentaar bij HR 10 oktober 2014, ECLI:NL:HR:2014:2930, JOR 2014/297 (Kameleon Beheer IV/Bisscheroux q.q.)
In een reeks vastgoedtransacties werden koopsommen betaald onder de feitelijke waarde. Het hof nam aansprakelijkheid van de betrokken BV en haar bestuurder aan wegens schuldeisersbenadeling; de pauliana-vordering werd afgewezen. De Hoge Raad onderschrijft dit. Met het stranden van een pauliana-vordering is dus niet meteen de kans op een succesvolle onrechtmatige-daadactie verkeken.
Classification of Benign and Malignant Thyroid Nodules Using Wavelet Texture Analysis of Sonograms
Authors: Ardakani Ali Abbasian , Gharbali Akbar , Mohammadi Afshin 
Published: October 2015

ObjectivesThe purpose of this study was to evaluate a computer‐aided diagnostic system using texture analysis to improve radiologic accuracy for identification of thyroid nodules as malignant or benign.MethodsThe database comprised 26 benign and 34 malignant thyroid nodules. Wavelet transform was applied to extract texture feature parameters as descriptors for each selected region of interest in 3 normalization schemes (default, μ ± 3σ, and 1%–9%). Linear discriminant analysis and nonlinear discriminant analysis were used for texture analysis of the thyroid nodules. The first–nearest neighbor classifier was applied to features resulting from linear discriminant analysis. Nonlinear discriminant analysis features were classified by using an artificial neural network. Receiver operating characteristic curve analysis was used to examine the performance of the texture analysis methods.ResultsWavelet features under default normalization schemes from nonlinear discriminant analysis indicated the best performance for classification of benign and malignant thyroid nodules and showed 100% sensitivity, specificity, and accuracy; the area under the receiver operating characteristic curve was 1.ConclusionsWavelet features have a high potential for effective differentiation of benign from malignant thyroid nodules on sonography.
Nomograms for Fetal Cardiac Ventricular Width and Right‐to‐Left Ventricular Ratio
Authors: Gabbay-Benziv Rinat , Turan Ozhan M. , Harman Chris , Turan Sifa 
Published: October 2015

ObjectivesTo establish nomograms for right ventricular (RV) and left ventricular (LV) widths and their ratio from 16 to 38 gestational weeks.MethodsWe conducted a retrospective evaluation of 1242 fetal echocardiographic examinations with normal findings in a single referral medical center between 2007 and 2013. We excluded all echocardiographic examinations with abnormal findings. The RV and LV widths, measured in end diastole from inner to inner line below the valves' insertion at the 4‐chamber view, were obtained. Nomograms for the RV and LV widths and RV/LV ratio from 16 to 38 gestational weeks were constructed by using separate best‐fitted regression models for estimation of mean and standard deviation at each gestational age (GA).ResultsRegression models for the RV and LV widths and RV/LV ratio were best fit by different‐degree polynomial regression. The mean RV and LV widths and RV/LV ratio (±2 SD) increased statistically with GA from 16 to 38 weeks: 4.13 (3.00–5.44) to 16.68 (12.98–20.83) mm, 4.21 (3.18–5.49) to 15.17 (11.60–19.56) mm, and 1.03 (0.87–1.23) to 1.06 (0.87–1.30), respectively. Although the width increments in the RV and LV were both statistically and clinically significant, the ratio increment seemed to fall into the error of measurement and thus has no clinical significance.ConclusionsReference values for cardiac ventricle widths and their ratio throughout gestation were established. The RV/LV ratio increases with GA, although without clinical significance. These reference values will be useful in objective assessment of RV‐to‐LV disproportion.
Correlation Between Abdominal Muscle Thickness and Maximal Expiratory Pressure
Authors: Ishida Hiroshi , Suehiro Tadanobu , Kurozumi Chiharu , Ono Koji , Watanabe Susumu 
Published: October 2015

ObjectivesThe activity of abdominal muscles mainly produces high expiratory pressure. These include the rectus abdominis, external oblique, internal oblique, and transverse abdominis muscles. The purpose of this study was to determine whether maximal expiratory pressure is associated with each abdominal muscle thickness at rest.MethodsThirty‐nine healthy male volunteers (mean age ± SD, 20.7 ± 2.7 years) participated in the study. The thickness of the right rectus abdominis, external oblique, internal oblique, and transverse abdominis muscles was measured by B‐mode sonography in the supine position. The maximal expiratory pressure was obtained with a spirometer in the sitting position. The correlations between each abdominal muscle thickness and maximal expiratory pressure were determined by the Pearson correlation coefficient.ResultsThe correlation coefficient between the rectus abdominis muscle and maximal expiratory pressure was 0.571 (P< .001). Correlation coefficients between the external oblique, internal oblique, and transverse abdominis muscles and maximal expiratory pressure were 0.297 (P = .066), 0.267 (P = .100), and 0.022 (P = .894), respectively.ConclusionsOur results indicate that the rectus abdominis muscle thickness might be more highly correlated with expiratory pressure production than the external oblique, internal oblique, and transverse abdominis muscle thickness.
Reliability Assessment of Various Sonographic Techniques for Evaluating Carpal Tunnel Syndrome
Authors: Junck Anthony D. , Escobedo Eva M. , Lipa Bethany M. , Cronan Michael , Anthonisen Colleen , Poltavskiy Eduard , Bang Heejung , Han Jay J. 
Published: October 2015

ObjectivesThe aim of this study was to determine the intra‐ and inter‐rater reliability of sonographic measurements of the median nerve cross‐sectional area in individuals with carpal tunnel syndrome and healthy control participants.MethodsThe median nerve cross‐sectional area was evaluated by sonography in 18 participants with carpal tunnel syndrome (18 upper extremities) and 9 control participants (18 upper extremities) at 2 visits 1 week apart. Two examiners, both blinded to the presence or absence of carpal tunnel syndrome, captured independent sonograms of the median nerve at the levels of the carpal tunnel inlet, pronator quadratus, and mid‐forearm. The cross‐sectional area was later measured by each examiner independently. Each also traced images that were captured by the other examiner.ResultsBoth the intra‐ and inter‐rater reliability rates were highest for images taken at the carpal tunnel inlet (radiologist, r = 0.86; sonographer, r = 0.87; inter‐rater, r = 0.95; all P < .0001), whereas they was lowest for the pronator quadratus (r = 0.49, 0.29, and 0.72, respectively; all P < .0001). At the mid‐forearm, the intra‐rater reliability was lower for both the radiologist and sonographer, whereas the inter‐rater reliability was relatively high (r = 0.54, 0.55, and 0.81; all P < .0001). Tracing of captured images by different examiners showed high concordance for the median cross‐sectional area at the carpal tunnel inlet (r = 0.96–0.98; P < .0001).ConclusionsThe highest intra‐ and inter‐rater reliability was found at the carpal tunnel inlet. The results also demonstrate that tracing of the median nerve cross‐sectional area from captured images by different examiners does not contribute significantly to measurement variability.
The 2013Mw6.2 Khaki‐Shonbe (Iran) Earthquake: Insights into seismic and aseismic shortening of the Zagros sedimentary cover
Authors: Elliott J. R. , Bergman E. A. , Copley A. C. , Ghods A. R. , Nissen E. K. , Oveisi B. , Tatar M. , Walters R. J. , Yamini‐Fard F. 
Published: October 2015

Determining the relationship between folding and faulting in fold and thrust belts is important for understanding the growth of geological structures, the depth extent of seismic slip, and consequently, the potential earthquake hazard. The 2013Mw 6.2 Khaki‐Shonbe earthquake occurred in the Simply Folded Belt of the Zagros Mountains, Iran. We combine seismological solutions, aftershock relocations, satellite interferometry, and field observations to determine fault geometry and its relationship with the structure, stratigraphy, and tectonics of the central Zagros. We find reverse slip on two along‐strike, southwest dipping fault segments. The main shock rupture initiated at the lower northern end of the larger northwest segment. Based upon the hypocenter and rupture duration, slip on the smaller southern segment is likely aseismic. Both faults verge away from the foreland, toward the high‐range interior, contrary to the fault geometries depicted in many structural cross sections of the Zagros. The modeled slip occurred over two mutually exclusive depth ranges above 10 km, resulting in long (∼16 km), narrow rupture segments (∼7 km). Aftershocks cluster in the depth range 3–14 km. This indicates reverse slip and coseismic shortening occurred mostly or exclusively in the sedimentary cover, with slip distributions likely to be lithologically controlled in depth by the Hormuz salt at the base of the sedimentary cover (∼10–12 km), and the Kazhdumi Formation mudrocks at upper levels (∼4–5 km). Our findings suggest lithology plays a significant role in the depth extent of slip found in reverse faults in folded belts, providing an important control on the potential size of earthquakes.
The use of hyperspectral sounding information to monitor atmospheric tendencies leading to severe local storms
Authors: Weisz Elisabeth , Smith Nadia , Smith William L. 
Published: October 2015

AbstractOperational space‐based hyperspectral sounders like the Atmospheric Infrared Sounder, the Infrared Atmospheric Sounding Interferometer, and the Cross‐track Infrared Sounder on polar‐orbiting satellites provide radiance measurements from which profiles of atmospheric temperature and moisture can be retrieved. These retrieval products are provided on a global scale with the spatial and temporal resolution needed to complement traditional profile data sources like radiosondes and model fields. The goal of this paper is to demonstrate how existing efforts in real‐time weather and environmental monitoring can benefit from this new generation of satellite hyperspectral data products. We investigate how retrievals from all four operational sounders can be used in time series to monitor the preconvective environment leading up to the outbreak of a severe local storm. Our results suggest the potential benefit of independent, consistent, and high‐quality hyperspectral profile information to real‐time monitoring applications.
North Atlantic ecosystem sensitivity to Holocene shifts in Meridional Overturning Circulation
Authors: Douarin Mélanie , Elliot Mary , Noble Stephen R. , Moreton Steven G. , Long David , Sinclair Daniel , Henry Lea‐Anne , Roberts J. Murray 
Published: October 2015

AbstractRapid changes in North Atlantic climate over the last millennia were driven by coupled sea surface/atmospheric processes and rates of deep water formation. Holocene climate changes, however, remain poorly documented due to a lack of high‐resolution paleoclimate records, and their impacts on marine ecosystems remain unknown. We present a 4500 year absolute‐dated sea surface radiocarbon record from northeast Atlantic cold‐water corals. In contrast to the current view that surface ocean changes occurred on millennial‐scale cycles, our record shows more abrupt changes in surface circulation. Changes were centered at 3.4, 2.7, 1.7, and 1.2 kyr B.P. and associated with atmospheric reorganization. Solar irradiance may have influenced these anomalies but changes in North Atlantic deep water convection are likely to have amplified these signals. Critically, we provide the first evidence that these perturbations in Atlantic Meridional Overturning Circulation led to the decline of cold‐water coral ecosystems from 1.2 to ~ 0.1 kyr B.P.
Geophysical evidence for the extent of crustal types and the type of margin along a profile in the northeastern Baffin Bay
Authors: Altenbernd Tabea , Jokat Wilfried , Heyde Ingo , Damm Volkmar 
Published: October 2015

AbstractInvestigating the crust of northern Baffin Bay provides valuable indications for the still debated evolution of this area. The crust of the southern Melville Bay is examined based on wide‐angle seismic and gravity data. The resulting P wave velocity, density, and geological models give insights into the crustal structure. A stretched and rifted continental crust underneath southern Melville Bay is up to 30 km thick, with crustal velocities ranging between 5.5 and 6.9 km/s. The deep Melville Bay Graben contains a 9 km thick infill with velocities of 4 to 5.2 km/s in its lowermost part. West of the Melville Bay Ridge, a ~80 km wide and partly only 5 km thick Continent‐Ocean Transition (COT) is present. West of the COT, up to 5 km thick sedimentary layers cover a 4.3 to 7 km thick, two‐layered oceanic crust. The upper oceanic layer 2 has velocities of 5.2 to 6.0 km/s; the oceanic layer 3 has been modeled with rather low velocities of 6.3 to 6.9 km/s. Low velocities of 7.8 km/s characterize the probably serpentinized upper mantle underneath the thin crust. The serpentinized upper mantle and low thickness of the oceanic crust are another indication for slow or ultraslow spreading during the formation of the oceanic part of the Baffin Bay. By comparing our results on the crustal structure with other wide‐angle seismic profiles recently published, differences in the geometry and structure of the crust and the overlying sedimentary cover are revealed. Moreover, the type of margin and the extent of crustal types in the Melville Bay area are discussed.