bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular and molecular events in colorectal cancer: biological mechanisms, cell death pathways, drug resistance and signalling network interactions
Authors: Yan Lei , Shi Jia , Zhu Jiazuo 
Published: July 2024

AbstractColorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, affecting millions each year. It emerges from the colon or rectum, parts of the digestive system, and is closely linked to both genetic and environmental factors. In CRC, genetic mutations such as APC, KRAS, and TP53, along with epigenetic changes like DNA methylation and histone modifications, play crucial roles in tumor development and treatment responses. This paper delves into the complex biological underpinnings of CRC, highlighting the pivotal roles of genetic alterations, cell death pathways, and the intricate network of signaling interactions that contribute to the disease's progression. It explores the dysregulation of apoptosis, autophagy, and other cell death mechanisms, underscoring the aberrant activation of these pathways in CRC. Additionally, the paper examines how mutations in key molecular pathways, including Wnt, EGFR/MAPK, and PI3K, fuel CRC development, and how these alterations can serve as both diagnostic and prognostic markers. The dual function of autophagy in CRC, acting as a tumor suppressor or promoter depending on the context, is also scrutinized. Through a comprehensive analysis of cellular and molecular events, this research aims to deepen our understanding of CRC and pave the way for more effective diagnostics, prognostics, and therapeutic strategies.
Properties of encapsulated raspberry powder and its efficacy for improving the color stability and amino acid composition of pastırma cemen pastes with different pH during long term cold-storage
Authors: Aksu Muhammet Irfan , Konar Nevzat , Turan Emre , Tamtürk Faruk , Serpen Arda 
Published: July 2024

Abstract
In this study, the changes in the physicochemical properties, color stability, and amino acid composition of cemen paste (CP) produced by adjusting to different pH levels (3.0, 4.0, 5.0, and 6.0) and enriched with different amounts (0%, 3%, 4% and 5%) of encapsulated raspberry powders (ERP) during 120 days of storage at 2.0 ± 0.5 °C were investigated. ERP had an important potential for use as a food ingredient with its bioactive components (total phenolic content (TPC), anthocyanin and ascorbic acid), antioxidant activity and high redness values. Essential and non-essential amino acid composition, moisture content, pH, lightness (L*), redness (a*), yellowness (b*), chroma (C*) and hue angle (o
h) values of cemen pastes (CPs) were significantly (p < 0.01) affected by initial pH of CP (I-pH), ERP levels (ERPL) and storage time (ST) parameters and all possible interactions. The inclusion of ERP contributed to the improvement of CP visual properties and color stability by increasing redness. CPs with lower I-pH values had higher a* values and higher color stability over the storage period. In general, increasing ERPL and decreasing I-pH resulted in decreased amino acid contents of CPs. In conclusion, acidification (3.0, 4.0) of I-pH of CP and using ≥ 4.00% ERP can be recommended as an effective way to provide more stable samples based on color characteristics and amino acid content.

Graphical abstract
A performance-driven framework with a system-of-systems approach for augmented asset management of railway system
Authors: Kumari Jaya , Karim Ramin , Dersin Pierre , Thaduri Adithya 
Published: July 2024

AbstractThe railway system is a complex technical system-of-systems (SoS). To address the complexity of the railway system, a holistic approach is needed that facilitates the development of an appropriate asset management regime. A systems-of-systems (SoS) approach considers the complex nature of the railway system, comprising interconnected subsystems like rolling stock and infrastructure. Neglecting these interdependencies risks sub-optimization of the overall system performance. Asset management of the railway system utilising a SoS approach ensures the focus of asset management on overall system requirements. The efficiency and effectiveness of the railway system is based on aspects such as availability, reliability, and safety performance. To enhance these aspects, monitoring, and improvement of key performance indicators (KPIs) emphasizing increased capacity and reduced operational costs is essential. The KPIs offer quantifiable parameters for performance optimization. Augmenting asset management through data-driven technologies can improve the efficiency and effectiveness of asset management. However, challenges persist in the implementation of data-driven solutions due to the railway system’s complexity and lack of a holistic perspective. A systematic performance-driven framework with a system-of-systems approach for augmented asset management of railway system provides handrail for the utilisation of data-driven technologies with railway system requirements at the centre while developing an asset management regime. The proposed framework aims to establish a clear relationship between system KPIs, and the performance of sub-systems and components aiding railway organizations in asset management design and implementation. This paper explains the important components of the proposed framework and demonstrates the application the framework for asset management and maintenance planning of high value components in the fleet of railway rolling stock. Adoption of the proposed framework is expected to enhance asset management through development and implementation of data-driven solutions that are aligned with system KPIs, to support asset management decision making.
The Role of Omega- 3 Polyunsaturated Fatty Acids in Diabetes Mellitus Management: A Narrative Review
Authors: Bayram Sümeyra Şahin , Kızıltan Gül 
Published: July 2024

Abstract
Purpose of Review
Diabetes mellitus (DM) is a group of metabolic illnesses characterized by elevated levels of glucose in the bloodstream as a result of abnormalities in the generation or function of insulin. Medical Nutrition Therapy (MNT) is an essential component of diabetes management. Dietary fats are essential in both the prevention and progression of chronic diseases. Omega-3 polyunsaturated fatty acids are recognized for their advantageous impact on health. They assist in controlling blood sugar levels and lipid profile in patients with all types of diabetes. Furthermore, they reduce the occurrence of cardiovascular events and death linked to DM.

Recent Findings
After evaluating the antioxidant, anti-inflammatory, antilipidemic, and antidiabetic mechanisms of omega-3 fatty acid supplements, as well as the results from randomized controlled studies, it is clear that these supplements have positive effects in both preventing and treating diabetes, as well as preventing and treating complications related to diabetes, specifically cardiovascular diseases.

Summary
However, current evidence does not support the use of omega-3 supplementation in people with diabetes for the purpose of preventing or treating cardiovascular events. People with all types of diabetes are suggested to include fatty fish and foods high in omega-3 fatty acids in their diet twice a week, as is prescribed for the general population.
Die Motivation älterer Pflegefachpersonen, im Pflegeberuf zu verbleiben: eine Querschnittstudie
Authors: Lipp Iris , Hahn Sabine 
Published: July 2024

Zusammenfassung
Hintergrund
Der Mangel an Pflegefachkräften ist weltweit gegenwärtig. In der Schweiz sind 50 % der Pflegefachpersonen ab 50 Jahren aus dem Pflegeberuf ausgestiegen. Dadurch gehen enorme fachliche und persönliche Ressourcen verloren. Maßnahmen zur Förderung des Berufsverbleibs sind daher zentral. Obwohl international Strategien für den Personalerhalt von älteren Pflegefachpersonen beschrieben und diskutiert werden, wurde das Thema im deutschsprachigen Raum bisher nur mangelhaft untersucht.

Ziel
Ziel war es, Einflussfaktoren zu beschreiben, die Pflegefachpersonen ab 50 Jahren dazu motivieren, bis zur ordentlichen Pensionierung in der direkten Pflege im Akutspital tätig zu sein.

Methode
Es wurde eine Querschnittstudie mit einer Vollerhebung mittels eines anonymen, standardisierten Fragebogens an einer privaten Spitalgruppe in der Schweiz durchgeführt.

Ergebnisse
Knapp 60 % (n = 115) der 195 angefragten Pflegefachpersonen im Alter ab 50 Jahren nahmen an der Befragung teil. Die Teilnehmenden nannten 3 zentrale Motivatoren für ihren Berufsverbleib: die gute Zusammenarbeit im Pflegeteam (73,7 %, n = 73), die abwechslungsreiche und interessante Tätigkeit (70,7 %, n = 70) sowie die Freude am Pflegeberuf (68,7 %, n = 68). Es zeigte sich eine statistisch signifikante monotone Korrelation zwischen dem Gesamtscore der beruflichen Identität und der Frage zum Berufsverbleib bis zur ordentlichen Pensionierung (p < 0,001, rs = 0,367).

Schlussfolgerungen
Eine hohe berufliche Identität ist eine wichtige Grundvoraussetzung für den langfristigen Verbleib im Pflegeberuf.
Retrospective evaluation of acute kidney injury in paediatric COVID-19 patients: a tertiary referral hospital experience
Authors: Yazılıtaş Fatma , Çakıcı Evrim Kargın , Güngör Tülin , Karakaya Deniz , Çelikkaya Evra , Şen Zeynep Savaş , Gümüşer Rüveyda , Tanır Naciye Gönül , Bülbül Mehmet 
Published: July 2024

Abstract
Background
Coronavirus disease 2019 (COVID-19) has been recognised as a risk factor for acute kidney injury (AKI). Our aim was to investigate the risk factors contributing to hospitalised and outpatient paediatric COVID-19-associated AKI.

Methods
A retrospective observational study was conducted on patients aged 1 month to 18 years with diagnosed COVID-19-associated AKI applied to a tertiary paediatric referral hospital between March 1, 2020 and March 1, 2022.

Results
A total of 6683 patients were evaluated and 486 patients were included in the study. Acute kidney injury was observed in 3.7% of outpatients and 23.9% of hospitalised patients. Multivariate logistic regression analysis showed that, on admission, a history of contact with a COVID-19 positive person (p < 0.001), age below 12 months (p = 0.004), presence of comorbidities (p < 0.001), abdominal pain (p = 0.008), anorexia (p = 0.003), dyspnoea (p = 0.005), higher lactate dehydrogenase values (p = 0.004), neutrophilia (p < 0.001), higher neutrophil-to-lymphocyte ratio (NLR) (p = 0.003), higher white blood cell counts (p = 0.006), elevated C-reactive protein (CRP) levels (p = 0.002), anaemia (p = 0.015), hypoalbuminaemia (p < 0.001), hyperglycaemia (p = 0.006), and presence of proteinuria (p = 0.003) were independent predictors of AKI. Higher rates of hospitalisation (p < 0.001) and admission to the paediatric intensive care unit (PICU) (p < 0.001), longer length of hospitalisation (p < 0.001), and greater need for mechanical ventilation (p < 0.001) were associated with AKI.

Conclusions
This study reveals that not only hospitalised children, but also paediatric patients are at risk for AKI. The presence of comorbidities, abdominal pain, anorexia, dyspnoea, anaemia, inflammation, hypoalbuminaemia, proteinuria and history of contact with a COVID-19 positive person were the main risk factors for AKI. COVID-19-associated AKI was associated with worse outcomes.

Graphical abstract
Rank deviations for overpartitions
Authors: Lovejoy Jeremy , Osburn Robert 
Published: July 2024

AbstractWe prove general fomulas for the deviations of two overpartition ranks from the average. These formulas are in terms of Appell–Lerch series and sums of quotients of theta functions and can be used, among other things, to recover any of the numerous overpartition rank difference identities in the literature. We give two illustrations.
An Evaluation of Positive Psychology Primals and Implications for Psychology
Authors: Capic T. , Khor S. , Misuraca G. , Fuller-Tyszkiewicz M. , Cummins R. A. 
Published: July 2024

AbstractThis article describes two studies which test predictions derived from the Theory of Subjective Wellbeing Homeostasis in relation to self-report, correlational data. The theory proposes that all self-report data contain a common source of variance called Homeostatically Protected Mood (HPMood). It is therefore hypothesised that the magnitude of inter-correlations between self-report measures will diminish after their shared variance of HPMood has been removed. The first study analyses the extent to which the Primal World Beliefs (Primals) correlate with subjective wellbeing (SWB), before and after controlling for HPMood. The second study confirms the reliability of study 1 results. It also extends the analyses to examine the correlation between the brief 4-item Primals measure, and other related self-report measures, again before and after controlling for the HPMood. Analyses are based on data from approximately 1,000 participants collected at two timepoints. The hypotheses are supported, showing that both the Primals and other tested measures do not represent constructs that are independent from HPMood. This result throws doubt on the interpretation of correlations between Primals and the other self-report variables that were tested, bringing into question the validity of positive psychology overall.
Chronotopische Identitäten in Smartphone-basierten Interaktionen
Authors: Busch Florian 
Published: July 2024

ZusammenfassungVor dem Hintergrund gesteigerter Mobilität sowie der gesellschaftlich nahezu flächendeckenden Verbreitung des Smartphones geht der Beitrag der zeitlichen und räumlichen Flexibilisierung von sozialen Identitäten und situativen Kontexten in digitalen Kommunikationsalltagen nach. Mit Bezug auf das theoretische Konzept des ›Chronotopos‹ werden kommunikative Praktiken in alltäglicher Smartphone-Kommunikation in Hinblick auf ihre raumzeitliche Gebundenheit und interdiskursive Geschichte perspektiviert. Dabei wird zum einen dargestellt, wie sich unterschiedliche soziale Kontexte und Identitäten in der alltäglichen Smartphone-Kommunikation von Individuen überlagern, indem Sprecher:innen zeitgleich mit verschieden Kommunikationspartner:innen interagieren, und wie diese Überlagerung zum anderen mit einer temporalen Verdichtung mehrsprachiger Praktiken einhergeht.
The adherence of Turkish emergency departments to geriatric guideline recommendations
Authors: Çelik Şimşek , Çelik Pelin 
Published: July 2024

Abstract
Objectives
This study aims to determine the availability of geriatrics-friendly protocols, pieces of equipment, and physical environments alongside potential opportunities of improvement in the emergency departments of our country.

Methods
This prospective, cross-sectional study was conducted between the 1st and 29th of February, in the year 2024, within the AI, AII, B group- and university hospitals in Turkey. A questionnaire form consisting of three subdivisions in which general pieces of information, information regarding appropriate personnel/management for geriatrics-friendly emergency departments, equipment/materials, and the presence of physical environments was presented online to the participants and the responses that were provided online were evaluated.

Results
The study was conducted with a total of 175 participants from hospital emergency departments. The number of hospitals with monthly older patient application amounts of 500 and above was 133 (76.0%). It was observed that personnel/management knowledge was, relative to guideline suggestions, at low levels. When the appropriateness of personnel/management knowledge and total equipment/materials were compared to hospital roles, it was determined that university hospitals adhered closest to the guideline and that inter-group differences were significant (p < 0.001).

Conclusions
It was determined that the compliance of emergency departments in Turkey with the criteria specified in the geriatric emergency department guidelines is at very low levels.
A comprehensive review to evaluate the synergy of intelligent food packaging with modern food technology and artificial intelligence field
Authors: Abekoon Thilina , Buthpitiya B. L. S. K. , Sajindra Hirushan , Samarakoon E. R. J. , Jayakody J. A. D. C. A. , Kantamaneni Komali , Rathnayake Upaka 
Published: July 2024

AbstractThis study reviews recent advancements in food science and technology, analyzing their impact on the development of intelligent food packaging within the complex food supply chain. Modern food technology has brought about intelligent food packaging, which includes sensors, indicators, data carriers, and artificial intelligence. This innovative packaging helps monitor food quality and safety. These innovations collectively aim to establish an unbroken chain of food safety, freshness, and traceability, from production to consumption. This research explores the components and technologies of intelligent food packaging, focusing on key indicators like time–temperature indicators, gas indicators, freshness indicators, and pathogen indicators to ensure optimal product quality. It further incorporates various types of sensors, including gas sensors, chemical sensors, biosensors, printed electronics, and electronic noses. It integrates data carriers such as barcodes and radio-frequency identification to enhance the complexity and functionality of this system. The review emphasizes the growing influence of artificial intelligence. It looks at new advances in artificial intelligence that are driving the development of intelligent packaging, making it better at preserving food freshness and quality. This review explores how modern food technologies, especially artificial intelligence integration, are revolutionizing intelligent packaging for food safety, quality, reduced waste, and enhanced traceability.
Fortifying crop defenses: unraveling the molecular arsenal against aphids
Authors: Yang Xiaodong , Zhang Lili , Li Yao , Liu Xiaowei , Chen Chaoyan , Deng Yizhuo , Zhou Wei , Sohail Hamza , Qiu Lei , Gu Jieni , Liu Fang , Chen Xuexin , Chen Xuehao 
Published: July 2024

AbstractAphids cause enormous financial losses to various crop plants on a global scale. Moreover, aphids are vectors for many plant viral diseases that can further hasten crop yield losses. Aphids secrete saliva during feeding that contains effectors that can regulate plants' defense responses and their underlying mechanisms. Although much research has been undertaken to determine the mechanisms contributing to plant-aphid interactions, our understanding of defense mechanisms against aphids is insufficient. The presence of piercing-sucking mouthparts in aphids makes the identification of aphid resistance more challenging, hindering our understanding of the mechanisms of plant resistance to aphids. In this article, we consolidate and assess the evidence that is currently available on plant-aphid interactions, address the gaps in our understanding, and propose new research directions. As an outcome, we present an in-depth review of the molecular mechanisms of aphid resistance in crops from five perspectives: physical protection against aphids using volatile compounds, PAMP-triggered immunity (PTI), effector-triggered immunity (ETI), plant hormone signaling and the inheritance of induced resistance through epigenetics.
Impact of Islands on Tidally Dominated River Plumes: A High‐Resolution Modeling Study
Authors: Li Xiangyu , Chrysagi Evridiki , Klingbeil Knut , Burchard Hans 
Published: July 2024

AbstractWhen flow passes over topographic features such as headlands and islands, island wakes can arise at the lee side of the flow. Island wakes are associated with enhanced biological productivity, increased mixing, and water mass transformation. While previous studies have mainly focused on the dynamical and biological effects of island wakes in the open ocean, here we focus on a large tidally‐dominated estuary with numerous islands, aiming to investigate the impact of such wakes on the offshore transport of river plumes. To this end, we use numerical simulations with unprecedented grid resolution in the plume region and around the islands. Our study area is the Pearl River Estuary, a region where satellite images indicate that oscillating wakes occur in the lee and far downstream of the islands. We show that submesoscale island wakes are ubiquitous in the plume‐influenced region and can affect a large area around the islands as the tidal flow reverses. These strong vorticity tails correspond well with the horizontal patterns of salinity gradients and salinity mixing. Sensitivity experiments show that these flow disturbances will largely decrease after the hypothetical “removal” of the islands. Analysis based on an isohaline coordinate framework shows that the isohaline surface area is limited by the presence of islands. It is proven that this “limiting” effect of islands on the plume extension is related to the salinity mixing and the associated diahaline water exchange.
Isopycnal Shoaling Causes Interannual Variability in Oxygen on Isopycnals in the Subarctic Northeast Pacific
Authors: Cervania Ahron A. , Hamme Roberta C. 
Published: July 2024

AbstractOver 60 years of oceanographic observations from Ocean Station Papa (OSP) in the northeast Pacific indicate faster dissolved oxygen loss than the global average. The greatest negative trends in oxygen concentration occur on isopycnals in the upper water column (σθ = 26.1–26.8 kg m−3, ∼110–200 m) but have considerable uncertainty due to natural variability. In this paper, we use eight Argo profiling floats equipped with optode oxygen sensors to assess the 2008–2016 interannual variability of subsurface dissolved oxygen near OSP. We developed a method using high frequency Conductivity‐Temperature‐Depth data to correct optode profiles for slow response times and used reference profiles from the OSP time series to calibrate the optodes. Response time correction markedly improves subsurface bias caused by slow optode equilibration. Our analysis indicates that episodic shoaling of isopycnals can cause rapid reduction in dissolved oxygen concentration. Changes in ventilation, horizontal mixing, and water mass age are unlikely drivers for the rapid O2 loss events examined. We link dissolved oxygen loss during shoaling events to organic matter export, due to higher concentrations of organic matter and greater respiration rates at shallower depths. Reduced net community production during the “Blob” marine heatwave may have reduced the impact of the second shoaling event examined. Natural variations in dissolved oxygen in these layers provide context for uncertainty estimates of long‐term trends and insight toward the potential for future extreme oxygen minima from the combined impact of the long‐term decline and episodic shoaling.