bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertension and kidney function in an adult population of West Bengal, India: Role of body weight, waist circumference, proteinuria and rural area living
Authors: Gallieni Maurizio , Ene‐Iordache Bogdan , Aiello Angela , Tucci Benedetta , Sala Valeria , Brahmochary Mandal Sujit K , Doneda Anna , Stella Andrea , Carminati Sergio , Perico Norberto , Genovesi Simonetta 
Published: July 2013

AbstractAimHypertension (HTN) and chronic kidney disease (CKD) are important emerging problems in low‐income countries, with an increasing number of patients dying from their consequences.MethodsA project for investigating these issues was carried out in West Bengal, India, in 2536 adult subjects. Body mass index (BMI) was classified using traditional and new cut‐offs identified by the World Health Organization for Asian populations. HTN was classified according to the Joint National Committee 7 and CKD according to presence of estimated glomerular filtration rate (eGFR) of less than 60 mL/min per 1.73 m2.ResultsNormal BMI (Asian reference) was found in 41.5% of subjects, while 33.4% were underweight, 19.3% overweight and 5.8% obese. Prevalence of stage 1 and 2 HTN was 39.4%. Proteinuria (urine dipstick >1+) was present in 7.7% of the sample. In a subsample of 1526 subjects, eGFR of less than 60 mL/min per 1.73 m2 was found in 4.2%. At multivariate analysis, factors associated with HTN were weight classes (P < 0.001), presence of proteinuria (P < 0.001) and family history of HTN (P = 0.028), while living in rural areas was associated with lower risk for HTN (P = 0.003). eGFR was inversely related to BMI (P = 0.03), the presence of proteinuria (P < 0.001) and HTN (P < 0.003), and directly related to living in rural areas (P = 0.003).ConclusionHigh prevalence of HTN was found in subjects with very limited access to health care in West Bengal. HTN was more common in overweight individuals, but also affected normal weight and underweight subjects in a significant part of the tested population. Preventive medicine should be a strong priority in this setting.
Leflunomide plus oral prednisone in treatment of idiopathic membranous nephropathy: A retrospective clinical study of efficacy and safety
Authors: Yang Shifeng , Xie Liyi , Xue Wujun , Yin Aiping , Lu Wanhong 
Published: July 2013

AbstractAimTreatment of idiopathic membranous nephropathy (IMN) remains a controversial issue. While clinical trials have shown that some immunosuppressants combined with glucocorticoid have a good efficacy on IMN patients. However, there is little data on leflunomide (LEF) in treatment of IMN.MethodsRecords of every patient with biopsy‐proven IMN in Department of Nephrology, the First Affiliated Hospital, Xi'an Jiaotong University from January 2005 to December 2011 (n = 194) were retrospectively analyzed. Patients with nephrotic IMN were treated with LEF plus oral prednisone (n = 32) for at least 12 months, whereas 31 patients who did not receive any immunosuppressants were used as controls.ResultsRemission rates in the LEF group were 31.3%, 59.4%, 68.8% and 71.9% at 6, 9, 12 and 15 months, respectively, which were significantly higher than those in controls. In the LEF group, proteinuria decreased from 6.79 g/24 h at baseline to 5.63 g/24 h (P < 0.01), 3.85 g/24 h (P < 0.01) and 2.51 g/24 h (P < 0.01) after treatment for 6, 9 and 12 months, respectively. Relapse occurred in five (21.7%) patients within a median of 14 months (range, 8–27) after cessation of LEF. No patients developed renal insufficiency during the therapeutic period. Multivariate analysis suggested that age negatively correlated with achievement of remission (odds ratio, 0.87; P < 0.05). No serious adverse events were observed.ConclusionLEF plus oral prednisone may be an alternative treatment option in Chinese patients with nephrotic IMN.
Comparative efficacy of a team‐led treatment protocol for the management of renal anaemia
Authors: Kotwal Sradha S , Lan Patrick , MacLeod Avril , Jardine Meg , Snelling Paul , Craig Jonathon , Cass Alan , Gallagher Martin 
Published: July 2013

AbstractAimTo evaluate the efficacy of a team‐led anaemia management protocol based on current guidelines.MethodsThe effect of a treatment protocol in implementing an anaemia guideline was evaluated in a large teaching hospital, encompassing three (two in‐hospital and one satellite) dialysis facilities. Quarterly data were collected, over a 6‐year period, on all patients dialysing in these facilities, before and after implementation of an anaemia management treatment protocol. This protocol was developed by a physician‐led team and implemented by an anaemia coordinator assisted by the unit staff. The primary outcome measure was the proportion of patients receiving erythropoietin with ferritin levels within the national guidelines target range calculated using data on haemoglobin (Hb), iron studies, dry weight and erythropoietin dose.ResultsData was collected on >150 patients every quarter between 2005 and 2010 (inclusive). The proportion of patients within the primary outcome target range increased from a nadir of 17% to 51% with evidence of true systematic change. The proportion of patients with Hb values within the unit target range also increased from 46% to 56% (P = 0.25) between the first and last years of the project. These changes were also associated with reduced erythropoietin drug use down to 0.44 μg/kg per week.ConclusionImplementation of a treatment protocol for anaemia management in haemodialysis patients was associated with greater consistency with guideline evidence and lower drug use. Achieving such guideline recommendations for ferritin targets in more than 50% of patients appears feasible.
Topical Timolol 0.5% Gel‐Forming Solution for Small Deep Facial Infantile Hemangiomas
Authors: Sorrell Jennifer , Chamlin Sarah L. 
Published: July 2013

AbstractWe report three cases of successful treatment of proliferating deep infantile hemangiomas with topical timolol 0.5% gel‐forming solution (GFS) used two to three times daily. We recommend considering timolol as an initial option for small, deep facial hemangiomas that are not causing functional compromise or complications but may have an unsatisfactory cosmetic appearance. In our experience, albeit limited, this is a safe alternative to watchful waiting.
Complete Genome Sequences of Two Human Respiratory Syncytial Virus Genotype A Strains from India, RSV-A/NIV1114046/11 and RSV-A/NIV1114073/11
Authors: Choudhary Manohar Lal , Wadhwa Bhumika S. , Jadhav Santosh M. , Chadha Mandeep S. 
Published: July 2013

ABSTRACT
Two complete genomes of human respiratory syncytial virus subtype A (HRSV-A), with and without a 72-nucleotide duplication in the C-terminal glycoprotein G gene, were sequenced and analyzed. Characterization of these genomes will improve understanding of the diversity, emergence, virulence, pathogenicity, and transmissibility of a novel RSV-A genotype with a 72-nucleotide G gene duplication.
Complete Genome Sequences of Both Biotypes of a Virus Pair of Bovine Viral Diarrhea Virus Subgenotype 1k
Authors: Marques Antunes de Oliveira Adriano , Stalder Hanspeter , Peterhans Ernst , Sauter Kay-Sara , Schweizer Matthias 
Published: July 2013

ABSTRACT
We determined the complete genome sequences of both biotypes of a virus pair of bovine viral diarrhea virus (BVDV) subgenotype 1k. The viruses were isolated from a persistently infected calf suffering from mucosal disease. Compared to the noncytopathic biotype, the cytopathic biotype contains an insertion of 84 nucleotides and 22 nucleotide changes.
Draft Genome Sequence of Pseudomonas fluorescens LMG 5329, a White Line-Inducing Principle-Producing Bioindicator for the Mushroom Pathogen Pseudomonas tolaasii
Authors: Ghequire Maarten G. K. , Rokni-Zadeh Hassan , Zarrineh Peyman , De Mot René 
Published: July 2013

ABSTRACT

Pseudomonas tolaasii
, the causative agent of
Agaricus bisporus
brown blotch disease, can be identified by the white line reaction, occurring upon confrontation of the tolaasin-producing mushroom pathogen with “
Pseudomonas reactans
,” producing the lipopeptide white line-inducing principle (WLIP). The draft genome sequence of the WLIP-producing indicator
Pseudomonas fluorescens
strain LMG 5329 is reported here.
Draft Genome Sequences of Porphyromonas crevioricanis JCM 15906
T
and Porphyromonas cansulci JCM 13913
T
Isolated from a Canine Oral Cavity
Authors: Sakamoto Mitsuo , Tanaka Naoto , Shiwa Yuh , Yoshikawa Hirofumi , Ohkuma Moriya 
Published: July 2013

ABSTRACT

Here, we report the draft genome sequences of
Porphyromonas crevioricanis
JCM 15906
T
and
Porphyromonas cansulci
JCM 13913
T
, which were isolated from a canine oral cavity and were recently united under the single species
P. crevioricanis
. These two genome sequences are very similar, and yet a high degree of genome rearrangements is observed.
Complete Genome Sequences of Two Astrovirus MLB1 Strains from Bhutanese Children with Diarrhea
Authors: Matsumoto Takashi , Wangchuk Sonam , Tshering Kinlay , Yahiro Takaaki , Zangmo Sangay , Dorji Tshering , Tshering Karchung , Mitui Marcelo Takahiro , Nishizono Akira , Ahmed Kamruddin 
Published: July 2013

ABSTRACT
In addition to the eight genotypes of classic human astroviruses, seven new genotypes have been reported from two novel clades, MLB and VA. However, the epidemiology of these highly diverse astroviruses remains largely unknown. We report here the complete genome sequences of two MLB1 strains from Bhutanese children with diarrhea.
Complete Genome Sequence of the Carbazole Degrader Pseudomonas resinovorans Strain CA10 (NBRC 106553)
Authors: Shintani Masaki , Hosoyama Akira , Ohji Shoko , Tsuchikane Keiko , Takarada Hiromi , Yamazoe Atsushi , Fujita Nobuyuki , Nojiri Hideaki 
Published: July 2013

ABSTRACT

Pseudomonas resinovorans
strain CA10 can grow on carbazole as its sole carbon and nitrogen source. Here, we report the complete nucleotide sequence of the CA10 genome (a 6,285,863-bp chromosome and a 198,965-bp plasmid). CA10 carries a larger number of genes that are potentially responsible for aromatic hydrocarbon metabolism than do other previously sequenced
Pseudomonas
spp.
Genome Sequence of Staphylococcus aureus Strain CA-347, a USA600 Methicillin-Resistant Isolate
Authors: Stegger Marc , Driebe Elizabeth M. , Roe Chandler , Lemmer Darrin , Bowers Jolene R. , Engelthaler David M. , Keim Paul , Andersen Paal S. 
Published: July 2013

ABSTRACT

The
Staphylococcus aureus
clonal lineage CC45 is a predominant colonizer of healthy individuals in northern Europe and constitutes a highly basal cluster of the
S. aureus
population. Here, we report the complete genome sequence of
S. aureus
strain CA-347 (NRS648), a representative of the methicillin-resistant USA600 clone predominantly found in the United States.
Draft Genome Sequences of Five Multilocus Sequence Types of Nonencapsulated Streptococcus pneumoniae
Authors: Keller Lance E. , Thomas Jonathan C. , Luo Xiao , Nahm Moon H. , McDaniel Larry S. , Robinson D. Ashley 
Published: July 2013

ABSTRACT

Nonencapsulated
Streptococcus pneumoniae
can colonize the human nasopharynx and cause conjunctivitis and otitis media. Different deletions in the capsular polysaccharide biosynthesis locus and different multilocus sequence types have been described for nonencapsulated strains. Draft genome sequences were generated to provide insight into the genomic diversity of these strains.
Draft Genome Sequence of Lactobacillus plantarum Strain IPLA 88
Authors: Ladero Victor , Alvarez-Sieiro Patricia , Redruello Begoña , del Rio Beatriz , Linares Daniel M. , Martin M. Cruz , Fernández María , Alvarez Miguel A. 
Published: July 2013

ABSTRACT

Here, we report a 3.2-Mbp draft assembly for the genome of
Lactobacillus plantarum
IPLA 88. The sequence of this sourdough isolate provides insight into the adaptation of this versatile species to different environments.
Key Regions of the Cerebral Network are Altered after Electroacupuncture at the Baihui (GV20) and Yintang Acupuncture Points in Healthy Volunteers: An Analysis Based on Resting fcMRI
Authors: Zhang Guifeng , Qu Shanshan , Zheng Yu , Chen Junqi , Deng Guizhu , Yang Canhong , Huang Yong 
Published: July 2013

Objective To identify the key cerebral functional region affected by acupuncture point needling by examining cerebral networks using functional connectivity MRI (fcMRI) and analysing changes in the key regions of these brain networks at different time points after needle removal. Methods Twelve healthy volunteers received 30 min of electroacupuncture (EA) at the Baihui (GV20) and Yintang acupuncture points and then underwent two fMRI scans, one each at 5 and 15 min after needle removal. Related brain networks were analysed centred at different ‘seeds’, centres which functionally connect the other cerebral regions in an organised network, such as the anterior frontal lobe, anterior cingulate gyrus, parahippocampal gyrus, amygdala, hypothalamus, head of the caudate nucleus and anterior lobe of the cerebellum. Networks were analysed based on the resting cerebral functional connection, and the differences in the activities of the brain networks between the two time points were compared. Results At 5 min after needle removal, 12 brain functional regions were involved in organising the network centred at the caudate nucleus ‘seed.’ This number was greater than the number of related brain networks centred at the other ‘seeds’. At 15 min after needle removal, 15 and 14 brain functional regions were involved in organised networks centred at the parahippocampal and hypothalamus ‘seeds’, respectively; these numbers were greater than the numbers of other related brain networks centred at the other ‘seeds’. Conclusions A brain network composed of a large number of cerebral functional regions was found after EA at GV20 and Yintang in healthy volunteers. The key brain ‘seed’ supporting the largest brain network changed between 5 and 15 min after needle removal.
Surgical technology and operating-room safety failures: a systematic review of quantitative studies
Authors: Weerakkody Ruwan A , Cheshire Nicholas J , Riga Celia , Lear Rachael , Hamady Mohammed S , Moorthy Krishna , Darzi Ara W , Vincent Charles , Bicknell Colin D 
Published: July 2013

BackgroundSurgical technology has led to significant improvements in patient outcomes. However, failures in equipment and technology are implicated in surgical errors and adverse events. We aim to determine the proportion and characteristics of equipment-related error in the operating room (OR) to further improve quality of care.MethodsA systematic review of the published literature yielded 19 362 search results relating to errors and adverse events occurring in the OR, from which 124 quantitative error studies were selected for full-text review and 28 were finally selected.ResultsMedian total errors per procedure in independently-observed prospective studies were 15.5, interquartile range (IQR) 2.0–17.8. Failures of equipment/technology accounted for a median 23.5% (IQR 15.0%–34.1%) of total error. The median number of equipment problems per procedure was 0.9 (IQR 0.3–3.6). From eight studies, subdivision of equipment failures was possible into: equipment availability (37.3%), configuration and settings (43.4%) and direct malfunctioning (33.5%). Observed error rates varied widely with study design and with type of operation: those with a greater burden of technology/equipment tended to show higher equipment-related error rates. Checklists (or similar interventions) reduced equipment error by mean 48.6% (and 60.7% in three studies using specific equipment checklists).ConclusionsEquipment-related failures form a substantial proportion of all error occurring in the OR. Those procedures that rely more heavily on technology may bear a higher proportion of equipment-related error. There is clear benefit in the use of preoperative checklist-based systems. We propose the adoption of an equipment check, which may be incorporated into the current WHO checklist.
Ar diffusion and solubility measurements in plagioclases using the ultra-violet laser depth-profiling technique
Authors: Wartho Jo-Anne , Kelley Simon P. , Elphick Stephen C. 
Published: July 2013

Abstract

We describe the first direct measurements of Ar diffusion and solubility in plagioclases using ultra-violet (UV) laser ablation depth-profiling and noble gas mass spectrometer analyses of experimentally treated (599–1000 °C, 50–200 MPa of Ar) crystal fragments of labradorite and oligoclase. Labradorite
40
Ar gain diffusion profiles were measured, yielding an activation energy of 26.72±4.58 kcal mol
−1
(118.0±19.16 kJ mol
−1
) and a frequency factor of 9.77×10
−9
(+8.79×10
−8
, −8.79×10
−9
) cm
2
s
−1
(95% confidence). The Ar solubility in labradorite was measured yielding a value of <0.2 ppb bar
−1
, which is similar to or lower than many rock forming minerals.

The labradorite diffusion parameters indicate Ar closure temperatures of 211 °C for a spherical diffusion geometry, and 243 °C for a planar diffusion geometry (for 100 µm-diameter grains, with cooling rates of 10 °C Ma
−1
). The data indicate that labradorite is less Ar retentive than K-feldspar at low temperatures, but more Ar retentive than K-feldspar at high temperatures, corroborating previous work on plagioclase. The relatively slow Ar diffusion rates in labradorite at magmatic temperatures may explain the common observation of older ages in large plagioclase grains in acidic volcanic systems.

Supplementary material:

Details of the UV laser depth profiles obtained from the labradorite and oligoclase samples used in this study are available at
www.geolsoc.org.uk/SUP18608
.
Neutron-induced
37
Ar recoil ejection in Ca-rich minerals and implications for
40
Ar/
39
Ar dating
Authors: Jourdan F. , Renne P. R. 
Published: July 2013

Abstract

The
40
Ar/
39
Ar dating technique requires the transformation of
39
K into
39
Ar by neutron activation. Neutron activation has undesirable secondary effects such as interfering isotope production, and recoil of
39
Ar and
37
Ar atoms from their (dominant) targets of K and Ca. In most cases, the grains analysed are large enough (>50 μm) such that the amount of target atoms ejected from the grains is small and has a negligible effect on the ages obtained. However, increasing needs to date fine-grained rocks requires constraining, and in some cases correcting for, the effect of nuclear recoil. Previous quantitative studies of recoil loss focus mostly on
39
Ar. However,
37
Ar loss can affect the ages of Ca-rich minerals via interference corrections on
36
Ar (and, to a lesser extent,
39
Ar), yielding lower
40
Ar*/
39
Ar
K
and, thus, an age spuriously too young. New results focused on
37
Ar recoil by measuring the apparent age of multi-grain populations of Ca-rich minerals including Fish Canyon plagioclase (FCp) and Hb3gr hornblende, with discrete sizes ranging from 210 to <5 µm. We use previous result on sanidine grains to correct for the
39
Ar recoil loss. For the finest fractions, FCp and Hb3gr apparent ages are younger than the
39
Ar recoil-corrected ages expected for these minerals, with a maximum deviation of −40% (FCp) and −21% (Hb3gr) reached for grains below 5 μm. We calculate
37
Ar-depletion values ranging from approximately 30 to 91% and from approximately 28 to 98% for plagioclase and hornblende, respectively. This results in
x
0
values (mean thickness of the partial depletion layer) of 3.3±0.4 μm (2σ; FCp) and 3.6±1.4 μm (Hb3gr), significantly higher than suggested by current models. The reason for the substantial
37
Ar loss is not well understood, but might be related to the radiation damage caused to the mineral during irradiation.
x
0
(
39
Ar) and
x
0
(
37
Ar) values obtained in this study, along with crystal dimensions, can be used for correcting
40
Ar/
39
Ar ages from
39
Ar and
37
Ar recoil loss. We also discuss the relevance of our results to vacuum-encapsulation studies and isotopic redistribution in fine-grained minerals.

Supplementary material:

Annex 1, 2 and 3 are available at
www.geolsoc.org.uk/SUP18610
. Annex 1 and 2: Raw argon data corrected for blank, mass discrimination and radioactive decay for Fish Canyon plagioclase (Annex 1) and Hb3gr hornblende (Annex 2). Annex 3: Step-heating
40
Ar/
39
Ar age spectra for FCp (Fig. A3.1) and Hb3gr (Fig. A3.2).
Some footnotes to the optimization-based calibration of the
40
Ar/
39
Ar system
Authors: Renne Paul R. 
Published: July 2013

Abstract

A recent calibration of the
40
Ar/
39
Ar geochronometer is based on an optimization analysis of
40
K activity data, isotopic data for the Fish Canyon sanidine (FCs) standard, and pairs of
40
Ar/
39
Ar+
238
U–
206
Pb data from selected samples meeting well-documented quality criteria. Inclusion of
238
U–
206
Pb data in the calibration incorporates the precisely known
238
U decay constant. Thus, this calibration is inherently consistent with the U–Pb chronometer. Initial presentation of the calibration included an inappropriate datum and should be eschewed in preference to a revision. Compared with previous calibrations, including those focusing mainly on the age of a standard (e.g. astronomical calibrations), the optimization calibration provides superior accuracy in the sense of propagated age uncertainty, particularly for ages much older than the FCs. Recent literature reveals that the optimization-based calibration has been misused and misrepresented in some cases; discussion of these cases clarifies the correct usage of the approach. Apparent conflict between
40
Ar/
39
Ar and
238
U–
206
Pb ages for a Quaternary tuff do not appear to be a result of error in one of the three parameters determined by the optimization approach for the
40
Ar/
39
Ar system. The optimization approach easily accommodates new constraints, but rigorous quality control is needed to maintain accuracy.
Myeloid-Derived Suppressor Cells as Osteoclast Progenitors: A Novel Target for Controlling Osteolytic Bone Metastasis
Authors: Sawant Anandi , Ponnazhagan Selvarangan 
Published: July 2013

Abstract
Immune cells and their secreted growth factors play major roles in tumor growth and metastasis. Interplay between the growing tumor and infiltrating immune cells determines the nature of immune response and ultimately, tumor fate. Increased infiltration of protumorigenic immune cells promotes tumor growth as well as dissemination to distant sites. These cells induce immunosuppression that inhibits proliferation and functions of cells of antitumor immune response. One population of immunosuppressive cells that is increasingly gaining attention is myeloid-derived suppressor cells (MDSC). MDSCs are immature myeloid progenitors that suppress T-cell effector functions and promote angiogenesis. MDSC numbers are elevated at both the primary tumor and metastatic sites, including bone. In addition to immunosuppressive functions of MDSCs, we and others have recently discovered a novel function for MDSCs as osteoclast progenitors. Osteolysis is a common complication in the carcinomas of breast, lung, prostate, and multiple myeloma with poor prognosis. Therefore, targeting the functions of MDSCs may exert dual therapeutic effects on immunosuppression and bone pathology. Cancer Res; 73(15); 4606–10. ©2013 AACR.