bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review
Authors: Goldsworthy Adrian , O’Callaghan Liam , Blum Ciara , Horobin Jarod , Tajouri Lotti , Olsen Mathew , Bruggen Natalia Van Der , McKirdy Simon , Alghafri Rashed , Tronstad Oystein , Suen Jacky , Fraser John F 
Published: August 2024

Abstract

Background
The human bioaccumulation of micro- and nano-plastics (MNPs) is increasingly being recognised in the aetiology and pathophysiology of human disease. This systematic scoping review provides a comprehensive investigation of studies examining the impacts of MNPs on the human cardiovascular system.
Methods
Five databases (PubMed, SCOPUS, CINAHL, Web of Science and EMBASE) were systematically searched.
Results
Thirty-four articles were identified, six of which investigated the presence of MNPs within the human cardiovascular system, including atherosclerotic plaques, saphenous vein tissue, and venous blood. The effect of MNPs on cell lines suggest MNPs are cytotoxic, immunotoxic, and genotoxic.
Discussion
The findings of this review, when evaluated together with additional studies utilising animal models, strongly suggest MNPs currently contribute to global cardiovascular morbidity and mortality. In particular, the ability of MNPs to induce endothelial damage, oxy-LDL formation, foam cell development and apoptosis, as well as altering the clotting cascade, has potential implications for vascular diseases. In addition, MNPs may play a role in the aetiology and progression of congenital heart abnormalities, infective pathologies and cardiomyopathies.
Conclusion
Despite an increasing awareness of the ability of MNPs to result in cardiovascular disease and dysfunction, a limited amount of research has been conducted to date characterising the presence of MNPs in the human cardiovascular system. Research is required to understand the extent of this rapidly emerging issue and to develop strategies that will support clinicians to appropriately manage and educate their patients about this issue in the future.
Nanomaterials in Targeting Cancer Cells with Nanotherapeutics: Transitioning Towards Responsive Systems
Authors: Jain Bhawana , Verma Dakeshwar Kumar , Rawat Reena Negi , Berdimurodov Elyor 
Published: August 2024

:
On a global scale, cancer is a difficult and devastating illness. Several problems with current chemotherapies
include cytotoxicity, lack of selectivity, stem-like cell growth, and multi-drug resistance. The
most appropriate nanomaterials for cancer treatment are those with characteristics, such as cytotoxicity, restricted
specificity, and drug capacity and bioavailability; these materials are nanosized (1-100 nm). Nanodrugs
are rarely licenced for therapeutic use despite growing research. These compounds need nanocarrier-targeted
drug delivery experiments to improve their translation. This review describes new nanomaterials reported
in the literature, impediments to their clinical studies, and their beneficial cancer therapeutic use. It also
suggests ways to use nanomaterials in cancer therapy more efficiently and describes the intrinsic challenges of
cancer treatment and the different nanocarriers and chemicals that can be utilised for specified tumour targeting.
Furthermore, it provides a concise overview of cancer theranostics methods, with a focus on those that
make use of nanomaterials. Although nanotechnology offers a great source for future advancements in cancer
detection and therapy, there is an emerging need for more studies to address the present barriers to clinical
translation.
Dysregulation of Porphyromonas gingivalis Agmatine Deiminase Expression in Alzheimer’s Disease
Authors: Hamdi Asma , Baroudi Sana , Gharbi Alya , Babay Wafa , Laaribi Ahmed Baligh , Kacem Imene , Mrabet Saloua , Zidi Ines , Klibi Naouel , Gouider Riadh , Ouzari Hadda-Imene 
Published: August 2024

Background:
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder,
with a significant burden on global health. AD is characterized by a progressive cognitive decline
and memory loss. Emerging research suggests a potential link between periodontitis, specifically
the presence of oral bacteria such as Porphyromonas gingivalis (P. gingivalis), and AD progression.
P. gingivalis produces an enzyme, Agmatine deiminase (AgD), which converts agmatine
to N-carbamoyl putrescine (NCP), serving as a precursor to essential polyamines. Recent studies
have confirmed the correlation between disruptions in polyamine metabolism and cognitive impairment.

Objective:
This study aims to investigate the dysregulation of P. gingivalis Agmatine deiminase
(PgAgD) in the context of AD.

Methods:
Saliva samples were collected from a total of 54 individuals, including 27 AD patients
and 27 healthy controls. The expression of the PgAgD gene was analyzed using quantitative Real--
Time PCR.

Results:
The results showed a significant decrease in PgAgD gene expression in the saliva samples
of AD patients compared to healthy controls. This downregulation was found in AD patients
with advanced stages of periodontitis. Additionally, a correlation was observed between the decrease
in PgAgD expression and the 30-item Mini-Mental State Examination (MMSE) score.

Conclusion:
These findings suggest that measuring PgAgD expression in saliva could be a noninvasive
tool for monitoring AD progression and aid in the early diagnosis of patients with periodontitis.
Further research is needed to validate our results and explore the underlying mechanisms linking
periodontitis, PgAgD expression, and AD pathophysiology.
Circulating Exosomes Studied by Label-free Proteomics Analysis Reveal Transition Signatures from Diabetes Mellitus to Diabetic Kidney Disease
Authors: Yue Yue , Tao Yiying , Wang Jiaxin , Zhao Shidi , Zhao Fan , Shen Lei , Zhou Ling 
Published: August 2024

Background:
Diabetic kidney disease (DKD) is a common microvascular complication
of diabetic mellitus (DM). At present, the early diagnosis of DKD mainly depends on microalbuminuria,
which is prone to be affected by confounding factors such as urinary tract infections.

Methods:
To identify the more stable early diagnosis markers, the whole proteome in the circulating
exosomes from controls, DM patients, and DKD patients was quantified by label-free proteomics
analysis and then validated with parallel reaction monitoring.

Results:
Three hundred ninety-one quantitative proteins were detected, and the expression trends
of 7 proteins in the validation phase were consistent with that in the discovery phase. The expression
level assessment results revealed that the expression of EFEMP1 and ApoA4 in the DKD
group was significantly higher than those in DM and controls. Correlation analysis showed that
EFEMP1 and APOA4 were positively correlated with urinary microalbumin and urinary albumin
creatinine ratio and had excellent diagnostic values for distinguishing DKD from DM and controls.

Conclusions:
ApoA4 and EFEMP1 could serve as the early diagnosis markers of DKD. These findings
provide a possibility for the development of a clinical diagnostic index that can efficiently
distinguish DKD from DM in the near future.
Recent Trends in the Development of Nanoparticles and Nanotechnology for Theranostics in Cancer Treatment
Authors: Ikbal Abu Md Ashif , Debnath Rabin , Choudhury Paromita Dutta , Jamatia Kulungti , Saha Sourav , Barbhuiya Amim Sultana , Singh Loushambam Samananda , Debnath Bikash , Singh Waikhom Somraj 
Published: August 2024

Abstract:
Theranostics is an innovative field that utilizes nanotechnology and nanoparticles for a
wide range of medical, diagnostic, and imaging applications. Therapeutic payloads, such as
chemotherapeutic drugs, nucleic acids, and medicinal proteins or peptides, can be enclosed within
nanoparticles or bonded to their surface for controlled release and extended circulation time.
Nanoparticles can be used to enhance drug accumulation at the tumor site by traversing biological
barriers such as the blood-brain barrier, using active or passive targeting techniques. Theranostic
systems based on nanotechnology offer various therapeutic approaches, including photodynamic
treatment (PDT), photothermal therapy (PTT), and gene therapy, which have become available in
recent decades. Researchers are exploring nanomaterials with unique surface chemistry and form to
combine cancer diagnosis with treatment methods, allowing for rapid diagnosis, precise imaging,
therapy with an adequate dose, and real-time supervision of therapeutic efficacy. This review
discusses various cancer theranostic applications, characterization techniques, synthesis steps, and
types of nanoparticles, including the imaging and diagnostic applications of nanoparticles in cancer.
Computer-aided Detection and Diagnosis of Cancer Regions in Mammogram Images using Resource-Efficient CNN Architecture
Authors: Thankaraj Helan Vidhya , Thiyagarajan Manikandan 
Published: August 2024

Aim:
The automatic computer-assisted mammogram classification system is important for women patients to detect and diagnose the cancer regions. In
this work, the mammogram images are classified into three cases: healthy, benign and cancer, using the proposed Resource Efficient Convolutional
Neural Network (RECNN architecture).

Methods:
The proposed mammogram image classification system consists of Data Augmentation (DA) module and Spatial transformation module and CNN
architecture with a segmentation module. The DA methods are used to increase the mammogram image count and Spatial Gabor Transform is used
as the spatial transformation module for transforming the spatial pixels into spatial-frequency pixels. Then, the proposed RECNN architecture is
used to perform the classification of mammogram images into healthy, benign and cancer cases. Further, the cancer mammogram images are
diagnosed as either ‘Early’ or ‘Severe’ using the proposed RECNN architecture in this work.

Results:
The proposed MCDS obtains 98.65% SeDR, 98.93% SpDR and 98.84% ADR for benign case mammogram images on DDSM dataset and also
obtains 98.84% SeDR, 98.7% SpDR and 98.92% ADR for benign case mammogram images on DDSM dataset. The proposed MCDS obtains
98.94% SeDR, 98.86% SpDR and 98.96% ADR for benign case mammogram images on DDSM dataset and also obtains 98.89% SeDR, 98.88%
SpDR and 99.03% ADR for benign case mammogram images on MIAS dataset.

Conclusion:
This proposed method is tested on the mammogram images from DDSM and MIAS datasets and the experimental results are compared with other
similar mammogram classification works in this paper. Based on several performance evaluation measures, the experimental results show that
MCDS outperforms the state-of-the-art methods currently used for the diagnosis and detection of mammography cancer.
The Transformative Potential of Oxidoreductases in Pollutant Remediation – A Review
Authors: Khalil Asia , Iqbal Ayman , Shabir Muhammad Aqib , Hasnain Ammarah , Niaz Zainab 
Published: August 2024

:
In this modern era, the environment is being contaminated with toxic pollutants as a result
of anthropogenic activities. To overcome the harmful effects of pollutants, scientists have developed
ideas and technologies. Biotechnology provides a green approach for decontaminating the environment,
i.e., bioremediation. Several organisms have been explored for their enzymes. Enzymes belonging
to various classes are useful for degrading, transforming, or removal of pollutants. Oxidoreductases
produced by different plants, bacteria, and fungi are useful for deterioration of toxic pollutants,
like compounds having aroma, called aromatic compounds (benzene, chlorine, phenols, phenanthrene,
etc.), PAHs (Polyaromatic Hydrocarbons), various dyes, etc. Oxidoreductases are further
classified as laccases, peroxidases, and oxygenases. All three classes have proven to be efficacious in
the field of bioremediation. Microorganism strains have also been genetically engineered for the production
of enzymes. Oxidoreductases can be used to remove pollutants from industrial waste. This
review has classified all the species that produce oxidoreductase enzymes, their mechanism of action,
and the pollutants that have been removed by using oxidoreductases.
Unveiling the Applications of Phytoconstituents in Neuropathic Pain
Authors: Priyanshi Rimjhim , Sharma Anjana , Kumar Shobhit , Gupta Arpana , Sharma Bhupesh , Sharma Nitin 
Published: August 2024

Background::
Neuropathic pain is a complex chronic condition resulting from the damage
or dysfunction of the nervous system. Conventional therapies offer limited success and often
come with various adverse effects. Therefore, the exploration of alternative therapies, such as phytoconstituents,
may be of substantial interest for their potential to alleviate neuropathic pain.

Objectives:
This review systematically examines the diverse roles and mechanisms of various phytoconstituents
in modulating neuropathic pain. In this study, a comprehensive analysis of phytoconstituents
in neuropathic pain is carried out to understand their mechanism in preventing the disease.

Method:
The current search is done in the databases of Google Scholar, PubMed Central, ScienceDirect,
and Scopus using the keywords: neuropathic pain, phytoconstituents as analgesics,
physiological effects of medicinal plants, and natural products, to find the most relevant articles of
the last 10 years.

Result:
Out of 125 articles, 112 were included in this study, which revealed that several phytoconstituents
inhibit several biomarkers responsible for neuropathic pain. Moreover, this review highlights
the underlying molecular pathways and targets through which these bioactive compounds
exert their therapeutic effects, emphasizing their potential as novel pharmacological agents.

Conclusion:
This study concludes that phytoconstituents may possess potential applications in managing
neuropathic pain and could be effectively used as an alternative approach to mitigate the
condition with enhanced risk of safety and tolerability.
An mHealth App to Support Caregivers in the Medical Management of Their Child With Cancer: Beta Stage Usability Study
Authors: Mueller Emily L , Cochrane Anneli R , Campbell Madison E , Nikkhah Sarah , Holden Richard J , Miller Andrew D 
Published: August 2024

Background
Previous research demonstrated that caregivers of children with cancer desired a mobile health (mHealth) tool to aid them in the medical management of their child. Prototyping and alpha testing of the Cope 360 app (Commissioning Agents, Inc) resulted in improvements in the ability to track symptoms, manage medications, and prepare for urgent medical needs.

Objective
This study aims to engage caregivers of children with cancer in beta testing of a smartphone app for the medical management of children with cancer, assess acceptance, identify caregivers’ perceptions and areas for improvement, and validate the app’s design concepts and use cases.

Methods
In this pilot, study caregivers of children with cancer used the Cope 360 mHealth app for 1 week, with the goal of daily logging. Demographics and a technology acceptance survey were obtained from each participant. Recorded semistructured interviews were transcribed and analyzed iteratively using NVivo (version 12, QSR International) and analyzed for information on usage, perceptions, and suggestions for improvement.

Results
A total of 10 caregivers participated in beta testing, primarily women (n=8, 80%), married, with some college education, and non-Hispanic White (n=10, 100%). The majority of participants (n=7, 70%) had children with acute lymphocytic leukemia who were being treated with chemotherapy only (n=8, 80%). Overall, participants had a favorable opinion of Cope 360. Almost all participants (n=9, 90%) believed that using the app would improve their ability to manage their child’s medical needs at home. All participants reported that Cope 360 was easy to use, and most would use the app if given the opportunity (n=8, 80%). These values indicate that the app had a high perceived ease of use with well-perceived usefulness and behavioral intention to use. Key topics for improvement were identified including items that were within the scope of change and others that were added to a future wish list. Changes that were made based on caregiver feedback included tracking or editing all oral and subcutaneous medications and the ability to change the time of a symptom tracked or medication administered if unable to do so immediately. Wish list items included adding a notes section, monitoring skin changes, weight and nutrition tracking, and mental health tracking.

Conclusions
The Cope 360 app was well received by caregivers of children with cancer. Our validation testing suggests that the Cope 360 app is ready for testing in a randomized controlled trial to assess outcome improvements.
Large Discordance between Creatinine-Based and Cystatin C–Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults
Authors: Katz-Agranov Nurit , Rieu-Werden Meghan L. , Thacker Ayush , Lykken Jacquelyn M. , Sise Meghan E. , Shah Sachin J. 
Published: August 2024

Key Points

A large eGFR discordance (i.e., cystatin C–based eGFR >30% lower than creatinine-based eGFR) is common in older adults and increased with age.A large eGFR discordance was associated with increased risk of falls, hospitalization, and death, independent of kidney function.There are multiple ways to measure differences in creatinine and cystatin C; all produce similar associations with aging-related adverse outcomes.

Background
eGFR calculated using creatinine and cystatin C often differ in older adults. We hypothesized that older adults with cystatin C–based eGFR (eGFRcys) values significantly lower than creatinine-based eGFR (eGFRcr) values may have higher risk of aging-related adverse outcomes, independent of kidney function.

Methods
We conducted a longitudinal cohort study of adults 65 years and older from the Health and Retirement Study, a cohort of older American adults, to determine the relationship between eGFR discordance and aging-related adverse outcomes. We calculated eGFRcr and eGFRcys using baseline creatinine and cystatin C measurements. A large eGFR discordance was defined as eGFRcys >30% lower than eGFRcr. We assessed four aging-related adverse outcomes over a 2-year follow-up: falls, hip fractures, hospitalizations, and death. We fit separate multivariable regression models to determine the association between having a large eGFR discordance and each outcome adjusting for confounders, including kidney function.

Results
Of 5574 older adults, 1683 (30%) had a large eGFR discordance. Those with a large eGFR discordance were more likely to be older, female, and White. The prevalence of a large eGFR discordance increased with age, from 20% among those 65–69 years to 44% among those 80 years and older. Over a 2-year follow-up, there were 305 deaths (5.5%), 2013 falls (39.2%), 69 hip fractures (1.3%), and 1649 hospitalizations (32.2%). In adjusted analyses, large eGFR discordance was associated with a higher hazard ratio for death (hazard ratio, 1.43; 95% confidence interval [CI], 1.12 to 1.82) and significantly higher odds of falls (odds ratio, 1.32; 95% CI, 1.16 to 1.51) and hospitalizations (odds ratio, 1.32; 95% CI, 1.15 to 1.51). A large eGFR discordance was not associated with hip fractures.

Conclusions
In a large, nationally representative cohort of older adults, prevalence of eGFR discordance increased with age and was associated with higher risk of falls, hospitalization, and death, independent of kidney function.
O PROFEPT no IFPR: contribuições para o desenvolvimento dos profissionais da EPT
Authors: Freira Rocha Cordeiro Machado Mércia , Paulino Kátia Regina , Grossl Fabiane Maria 
Published: August 2024

Este artigo apresenta uma investigação de abordagem qualitativa do tipo exploratória que objetivou analisar a produção científica do ProfEPT no IFPR no período de 2018 a 2022, com vistas a sua contribuição para o desenvolvimento profissional dos docentes e profissionais da Educação Profissional e Tecnológica. A investigação foi desenvolvida por meio de pesquisa documental, na qual foram analisadas 66 dissertações e seus respectivos produtos educacionais. Os resultados obtidos permitem concluir que as pesquisas e os produtos oriundos do ProfEPT nesses últimos cinco anos representam grandes conquistas, têm boas perspectivas e muitos desafios pela frente, bem como têm contribuído para a melhoria da qualidade da EPT no IFPR e na RFEPCT.
ABSTRACT
This article presents an investigation with a qualitative exploratory approach that aimed to analyze the scientific production of ProfEPT at IFPR from 2018 to 2022, in view of its contribution to the professional development of teachers and professionals in Professional and Technological Education. The investigation was developed through documentary research, in which 66 dissertations and their respective educational products were analyzed. The results obtained allow us to conclude that the research and products from ProfEPT in the last five years represent great achievements, have good perspectives and many challenges ahead, as well as contributed to the improvement of the quality of EPT in IFPR and RFEPCT.
RESUMEN
Este artículo presenta una investigación con enfoque cualitativo exploratorio que tuvo como objetivo analizar la producción científica de la ProfEPT en la IFPR de 2018 a 2022, con miras a su contribución al desarrollo profesional de docentes y profesionales de la Educación Profesional y Tecnológica. La investigación se desarrolló a través de una investigación documental, en la que se analizaron 66 disertaciones y sus respectivos productos educativos. Los resultados obtenidos permiten concluir que las investigaciones y productos de la ProfEPT en los últimos cinco años representan grandes logros, tienen buenas perspectivas y muchos desafíos por delante, así como han contribuido a la mejora de la calidad de la EPT en la IFPR y la RFEPCT.
The Meaning of the Pantang Larang on 1 Muharram for the Pemangkat Malay Society
Authors: Ramadhan Iwan , Khosihan Aan , Nurazizah Silmi , Suriyanisa Suriyanisa 
Published: August 2024

This study aims to explore the meaning of Pantang Larang on 1 Muharram for the Malay society in Pemangkat, Sambas Regency. This article is a qualitative study with a phenomenological approach. Data collection was conducted in July 2023 through participant observation and in-depth interviews. The data were analyzed according to Milles and Huberman's qualitative analysis model: data reduction, data display, and conclusions. The data obtained shows that there are five restrictions on the date of 1 Muharram for the Malay people in Pemangkat: the restriction of doing strenuous work, the restriction of traveling, the restriction to conducting a wedding celebration, the restriction of going to the forest and the plantation, and the restriction of playing outside for children. Data analysis found that the Malay society in Pemangkat meant Pantang Larang on 1 Muharram as an effort to achieve self-control, safety, health, and individual welfare. This meaning is formed based on ancestral experience stories from generation to generation in the Malay society in Pemangkat, creating cultural continuity.Keywords: Pantang Larang; 1 Muharram; Islamic Calendar; Malay Society; Pemangkat