bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of underlying diseases on pneumonia risk in patients with neurogenic or tumor-related dysphagia: a retrospective cohort study
Authors: Niessen Almut C. , Zang Jana , Tinat Ferkhunda , Nienstedt Julie C. , Müller Frank , Flügel Till , Glinzer Julia , Pflug Christina 
Published: July 2024

Abstract
Objective
To analyze the association of neurological disorders (ND) and head and neck cancer (HNC) with dysphagia severity and aspiration pneumonia occurrence.

Method
Retrospective cohort study conducted at a university dysphagia center) for two consecutive years. Patients with ND or HNC were included if they had undergone a flexible endoscopic swallowing evaluation (FEES) at the dysphagia center, and at least one food consistency had been sampled and recorded. Outcomes of interest were swallowing safety, highest penetration-aspiration-score (PASmax), way of food intake, presence of a tracheal tube, and occurrence of pneumonia within the past two years.

Results
Of 257 consecutive patients, 199 were enrolled in the study and classified according to their underlying diagnosis into ND (120 patients) or HNC (79 patients). Forty-three HNC patients (54.4%) and 54 ND patients (45%) showed critical dysphagia in FEES (PAS ≥ 6). Binary logistic regression comparing both groups showed patients with ND to be 2.31 times more likely to develop pneumonia. However, if the 32 stroke patients were excluded from the calculation, PASmax remains the only significant variable affecting pneumonia risk in both groups. Liquids were the main challenge for ND patients, while aspirating HNC patients struggled with all consistencies.

Conclusions
The study shows that patients with HNC and ND differ in pneumonia risk only if stroke patients are included in the ND group. If they are excluded, the PAS score is the only remaining risk factor for pneumonia. Thickening liquids may not be suitable for all dysphagic patients; individually tailored measures might be more helpful, especially for HNC patients.
HLA-DR3 ~ DQ2 associates with sensory neuropathy in paraneoplastic neurological syndromes with Hu antibodies
Authors: Muñiz-Castrillo Sergio , Villagrán-García Macarena , Peris Sempere Vicente , Farina Antonio , Pinto Anne-Laurie , Picard Géraldine , Rogemond Véronique , Honnorat Jérôme , Mignot Emmanuel 
Published: July 2024

Abstract
Objectives
To investigate the association between human leukocyte antigen (HLA) and paraneoplastic neurological syndromes (PNS) with Hu antibodies, and potential specificities according to clinical presentation and cancer status.

Methods
HLA genotypes at four-digit resolution were imputed from available genome-wide association data. Allele carrier frequencies were compared between patients (whole cohort, n = 100, and according to clinical presentation and cancer status) and matched healthy controls (n = 508) using logistic regression controlled by the three main principal components.

Results
The clinical presentation of 100 anti-Hu patients involved the central nervous system (28, 28%), the peripheral nervous system (36, 36%) or both combined (36, 36%). Cancer diagnosis was certain in 75 (75%). HLA association analyses revealed that anti-Hu PNS patients were more frequently carriers of DQA1*05:01 (39% vs. 19%, OR = 2.8 [1.74–4.49]), DQB1*02:01 (39% vs. 18%, OR = 2.88 [1.79–4.64]) and DRB1*03:01 (41% vs. 19%, OR = 2.92 [1.80–4.73]) than healthy controls. Remarkably, such DR3 ~ DQ2 association was absent in patients with pure central involvement, but more specific to those manifesting with peripheral involvement: DQA1*05:01 (OR = 3.12 [1.48–6.60]), DQB1*02:01 (OR = 3.35 [1.57–7.15]) and DRB1*03:01 (OR = 3.62 [1.64–7.97]); being even stronger in cases with sensory neuropathy, DQA1*05:01 (OR = 4.41 [1.89–10.33]), DQB1*02:01 (OR = 4.85 [2.04–11.53]) and DRB1*03:01 (OR = 5.79 [2.28–14.74]). Similarly, DR3 ~ DQ2 association was only observed in patients with cancer.

Discussion
Patients with anti-Hu PNS show different HLA profiles according to clinical presentation and, probably, cancer status, suggesting pathophysiological differences.
Pars interarticularis screws for posterior cervical fusion – investigating a new trajectory using a CT-based multiplanar reconstruction: Part I
Authors: Lener Sara , Wipplinger Christoph , Abramovic Anto , Koller Heiko , Thomé Claudius , Verius Michael , Hartmann Sebastian 
Published: July 2024

Abstract

Background
Lateral mass screw fixation is the standard for posterior cervical fusion between C3 and C6. Traditional trajectories stabilize but carry risks, including nerve root and vertebral artery injuries. Minimally invasive spine surgery (MISS) is gaining popularity, but trajectories present anatomical challenges.
Research Question.
This study proposes a novel pars interarticularis screw trajectory to address these issues and enhance in-line instrumentation with cervical pedicle screws.

Materials and Methods
A retrospective analysis of reformatted cervical CT scans included 10 patients. Measurements of the pars interarticularis morphology were performed on 80 segments (C3-C6). Two pars interarticularis screw trajectories were evaluated: Trajectory A (upper outer quadrant entry, horizontal trajectory) and Trajectory B (lower outer quadrant entry, cranially pointed trajectory). These were compared to standard lateral mass and cervical pedicle screw trajectories, assessing screw lengths, angles, and potential risks to the spinal canal and transverse foramen.

Results
Trajectory B showed significantly longer pars lengths (15.69 ± 0.65 mm) compared to Trajectory A (12.51 ± 0.24 mm; p < 0.01). Lateral mass screw lengths were comparable to pars interarticularis screw lengths using Trajectory B. Both trajectories provided safe angular ranges, minimizing the risk to delicate structures.

Discussion
and Conclusion.
Pars interarticularis screws offer a viable alternative to lateral mass screws for posterior cervical fusion, especially in MISS contexts. Trajectory B, in particular, presents a feasible and safe alternative, reducing the risk of vertebral artery and spinal cord injury. Preoperative assessment and intraoperative technologies are essential for successful implementation. Biomechanical validation is needed before clinical application.
The role of Bifidobacterium in longevity and the future of probiotics
Authors: Ku Seockmo , Haque Md Ariful , Jang Min Ji , Ahn Jaehyun , Choe Deokyeong , Jeon Jong Ik , Park Myeong Soo 
Published: July 2024

AbstractThis review explores the role and health impacts of probiotics, focusing specifically on Bifidobacterium spp. It highlights the functionalities that Bifidobacteria can provide, underscored by the historical evolution of definitions and technological advancements related to probiotics. By examining the association between Bifidobacteria and longevity, this review suggests new avenues for health enhancement. Highlighting case studies of centenarians, it presents examples related to human aging, illuminating the potential links to longevity through research on Bifidobacterium strains found in centenarians. This review not only emphasizes the importance of current research but also advocates for further investigation into the health benefits of Bifidobacteria, underlining the necessity for continuous study in the nutraceutical field.
Exploring the potential of Easy Language for enhancing website sustainability
Authors: González-Sordé Mariona 
Published: July 2024

AbstractSustainable design principles have become increasingly important in website development, mainly focusing on reducing carbon emissions and energy consumption. Easy language (EL) is a simplified language variety that makes websites more accessible to a wider range of users; but there has been no attention given to its usefulness in sustainability efforts. As such, this study is intended to become a starting point for future research in the area. By examining the intersection between EL and website sustainability guidelines and practices, the study highlights the potential for EL to contribute to sustainable website design. Along the paper, the following theory is defended: when adapted to Easy Language, text and interactions in websites are simplified, which makes them require less data transfer, become more efficient and, ultimately, more sustainable. The paper also presents a small comparative analysis of the sustainability of websites in EL and standard language that indicated that EL generally enhanced the sustainability of websites. The nine websites in EL analysed showed a mean reduction of CO2 production of 42% in comparison to their equivalents in standard language (p = 0.049, F = 2.42). The discussion and results presented open potential solutions for an urgent problem that deserve to be considered and researched further.
Alkali induced changes in spatial distribution of functional groups in carboxymethylated cellulose – comparison of cotton and viscose fibers
Authors: Bogner Paul , Mahmud-Ali Amalid , Bechtold Thomas , Pham Tung , Manian Avinash P. 
Published: July 2024

AbstractThe aim of the work was to compare the levels of carboxymethylation on cotton with what was obtained previously on viscose fibers under the same treatment conditions. In addition to carboxymethylation levels, their performance was also compared in terms of their propensity for sorption of methylene blue, a cationic dye that is a putative wastewater contaminant. Under comparable conditions of treatment, the degree of carboxymethylation in cotton was 30–90% of that in viscose but the molar ratio of dye sorption to carboxyl groups was 100–230% of that in viscose. In other words, as compared to cotton, viscose fibers showed higher degrees of carboxymethylation but lower accessibility of the carboxyl groups to dye molecules. The divergence between the fiber types is attributed to differences in the spatial distribution of substituted carboxymethyl groups within their structures, as well as the inherently greater swelling propensity of the viscose as compared to cotton. Further work is under way to determine if the order of performance as measured through dye sorption (cotton better than viscose) will also hold true if the performance metric is changed to water and moisture sorption.
Determination and risk assessment of UV filters and benzotriazole UV stabilizers in wastewater from a wastewater treatment plant in Lüneburg, Germany
Authors: Ajibola Akinranti S. , Reich Marco , Kümmerer Klaus 
Published: July 2024

AbstractUV filters and benzotriazole UV stabilizers are considered emerging contaminants in the environment. LC–MS/MS and GC–MS methods, involving a single solid phase extraction protocol, were developed and validated to determine eight UV filters and seven UV stabilizers, respectively in wastewater from a wastewater treatment plant (WWTP) in Lüneburg, Germany. The LC–MS/MS method exhibited extraction recoveries of ≥ 71% at six different fortification levels with limits of detection (LODs) range of 0.02 ng mL−1 – 0.09 ng mL−1. Extraction recoveries of 47 to 119% at six different fortification levels were obtained for the GC–MS method with LODs range of 0.01 – 0.09 ng mL−1. Among the UV filters, the highest mean concentration was determined for octocrylene (OCR) in influent (3.49 ng mL−1) while the highest mean concentration was measured for 2-hydroxy-4-octyloxybenzophenone (UV 531) in influent (0.44 ng mL−1) among the UV stabilizers. Potential risk to aquatic organisms was assessed by the risk quotient approach. Only OCR presented a high risk to aquatic invertebrates whereas 2-ethylhexyl 4-methoxycinnamate (EHMC) and 2-ethylhexyl salicylate (EHS) posed high risks to algae. Benzotriazole UV stabilizers presented negligible risks to aquatic invertebrates and fish. This work reports the detection of rarely studied 4-aminobenzoic acid (PABA) and UV 531 in WWTP influent and effluent. The occurrence and risk assessment of target benzotriazole UV stabilizers in wastewater from a German WWTP was demonstrated for the first time.
Life cycle assessment of aerogels: a critical review
Authors: Turhan Kara Ilkay , Kiyak Baris , Colak Gunes Neslihan , Yucel Sevil 
Published: July 2024

AbstractOver the past decade, the increasing emphasis on sustainable material production has brought aerogel technology to the forefront of scientific and industrial research. Aerogels are known for their extraordinary properties, such as high porosity and low density, which make them suitable for a wide range of applications from thermal insulation in buildings to drug delivery systems. This review systematically investigates the sustainability of aerogel production by analyzing the environmental impacts identified in recent life cycle assessments (LCAs). It examines studies on aerogel production using different precursors, solvents, and energy-intensive production methods, especially drying techniques, providing a comprehensive analysis of the environmental footprints and highlighting several hotspots. The review particularly focuses on identifying the disparities in LCA methodologies and the results obtained, which are crucial for crafting a roadmap toward more sustainable aerogel production. The findings emphasize the need for standardized functional units and lifecycle phases that reflect the specific applications of aerogels, thus enabling more accurate comparisons and assessments. The review concludes with a discussion of the critical gaps in current LCA studies of aerogels. It also offers sustainability recommendations based on identified hotspots, advocating for improvements in aerogel production techniques that minimize environmental impacts, enhance material efficiency, and reduce waste. By addressing these gaps, this paper aims to foster a deeper understanding of aerogel sustainability and encourage the development of more environmentally friendly practices in aerogel production and application.
Graphical Abstract
Green synthesis of Agaricus avensis-mediated silver nanoparticles for improved catalytic efficiency of tyrosine hydroxylase towards potential biomedical implications
Authors: Ali Sikander , Fatima Laraib , Ahmad Muhammad Usman , Khan Qaiser Farid , Hayyat Muhammad Umar , Siddiq Zafar , Patel Sanjaykumar , Shah Tawaf Ali , Jardan Yousef A. Bin , Younous Youssouf Ali , Bourhia Mohammed 
Published: July 2024

AbstractThe present study deals with the bio-fabrication of AgA-AgNPs utilizing edible mushroom Agaricus arvensis as a reductant for improved stability and catalytic efficiency towards L-dopa production. The parameters optimized for achieving maximum tyrosine hydroxylase (TH) activity were the mushroom biomass (2.5%, w/v), media for extraction (peptone-saline), and temperature (90 ℃). The activity of tyrosine hydroxylase (TH) was enhanced by its immobilization on AgNPs. The change in color from light yellow to dark brown confirmed the formation of AgA-AgNPs. In addition, the UV–Vis spectrum showed a surface plasmon resonance band at 260 nm. Fourier transform infrared (FTIR) indicated presence of functional groups, which play an important role in production of NPs. X-ray diffraction (XRD) confirmed the crystalline nature of mycosynthesized AgNPs and showed peaks corresponding to 38.8° (111), 46.5° (200), 64.1° (220), and 77.5o (311). AgA-AgNPs exhibited −9.16 mv zeta potential. Scanning Electron Microscopy (SEM) images of AgA-AgNPs confirmed particle size between 88.49 ± 3.83 nm. Immobilized TH extracted from A. arvensis showed reusability at optimized temperature (20 ℃) for 3 cycles. A 2.54-fold higher production of L-dopa was examined with AgA-AgNPs. Furthermore, immobilized TH consumed more L-tyrosine i.e. 0.554 ± 0.022 mg/ml as compared to the free enzyme at 90 min of biotransformation. Hence, the immobilization of A. arvensis extracted TH on AgNPs increased its activity as well as its stability and catalytic efficiency. AgA-AgNPs has a potential of dopamine synthesis and can play a significant role in drug delivery or biomedical applications.
Characterisation of urban aerosol size distribution by radiocarbon and PIXE analyses in a middle-European urban environment for source identification: a pilot study
Authors: Angyal Anikó , Szoboszlai Zoltán , Major István , Molnár Mihály , Varga Tamás , Török Zsófia , Papp Enikő , Enikő Furu , Gini Maria , Manousakas Manousos Ioannis , Szikszai Zita , Kertész Zsófia 
Published: July 2024

AbstractThis study, conducted in Debrecen, Hungary, aimed to analyse atmospheric particulate matter (APM or PM) through radiocarbon and PIXE analyses during the winter smog (23–25 January) and spring (15–18 May) seasons. The information presented in this pilot study aims to provide insight into the importance of utilising detailed characteristics of the mass size distributions of fossil carbon (ff) and contemporary carbon (fC) content. Additionally, it seeks to compare these characteristics with the size distributions of various elements to enable even more accurate PM source identification. In winter, APM concentrations were 86.27 μg/m3 (total), 17.07 μg/m3 (fC) and 10.4 μg/m3 (ff). In spring, these values changed to 29.5 μg/m3, 2.64 μg/m3 and 7.01 μg/m3, respectively. Notably, differences in mass size distribution patterns were observed between the two seasons, suggesting varied sources for contemporary carbon. Biomass burning emerged as a crucial source during the smog period, supported by similar MMAD (Mass Median Aerodynamic Diameter) values and a strong correlation (r = 0.95, p < 0.01) between potassium and fC. In spring, a significant change in the concentration and distribution of fC occurred, with a broad, coarse mode and a less prominent accumulation mode. Ff was found to have similar distributions as PM, with nearly the same MMADs, during both periods. Finally, a comprehensive comparison of modal characteristics identified specific sources for the various components, including biomass burning, vehicle exhaust, coal and oil combustion, vehicle non-exhaust, road dust, tyre abrasion, mineral dust and biogenic emission. This study showcases how using radiocarbon and PIXE analysis in size distribution data can enhance our understanding of the sources of PM and their effects on different size fractions of PM.
Sodium-Glucose Cotransporter 2 Inhibitors During Cancer Therapy: Benefits, Risks, and Ongoing Clinical Trials
Authors: Osataphan Nichanan , Abdel-Qadir Husam , Zebrowska Agnieszka Maria , Borowiec Anna 
Published: July 2024

Abstract
Purpose of review
The goal of this paper is to summarize the data pertaining to the use of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) for the prevention of cardiotoxicity in patients receiving anthracyclines for cancer treatment. We discuss the potential efficacy of this class of medications, incorporating insights from existing literature and ongoing studies.

Recent findings
SGLT2i are a class of medications which were initially developed for treatment of Type 2 diabetes and later extended to treat heart failure with reduced and preserved ejection fraction regardless of diabetes status. There remains a need for effective and safe treatments to preventing cardiotoxicity in anthracycline-treated patients. It has been proposed that SGLT2i may provide protection against the cardiotoxic effects of anthracyclines. Some of the proposed mechanisms include beneficial metabolic, neurohormonal, and hemodynamic effects, renal protection, as well as a decrease in inflammation, oxidative stress, apoptosis, mitochondrial dysfunction and ion homeostasis.

Summary
There is emerging evidence from basic science and observational studies that SGLT2i may play a role in the prevention of chemotherapy-induced cardiotoxicity. Randomized controlled trials are needed to conclusively determine the role of SGLT2 inhibitors as a cardioprotective therapy in patients receiving anthracyclines for the treatment of cancer.
Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment
Authors: Romero-Trejo Daniel , Aguiñiga-Sanchez Itzen , Ledesma-Martínez Edgar , Weiss-Steider Benny , Sierra-Mondragón Edith , Santiago-Osorio Edelmiro 
Published: July 2024

AbstractCancer is one of the leading causes of death worldwide, with over 10 million fatalities annually. While tumors can be surgically removed and treated with chemotherapy, radiotherapy, immunotherapy, hormonal therapy, or combined therapies, current treatments often result in toxic side effects in normal tissue. Therefore, researchers are actively seeking ways to selectively eliminate cancerous cells, minimizing the toxic side effects in normal tissue. Caseins and its derivatives have shown promising anti-cancer potential, demonstrating antitumor and cytotoxic effects on cells from various tumor types without causing harm to normal cells. Collectively, these data reveals advancements in the study of caseins and their derivative peptides, particularly providing a comprehensive understanding of the molecular mechanism of action in cancer therapy. These mechanisms occur through various signaling pathways, including (i) the increase of interferon-associated STAT1 signaling, (ii) the suppression of stemness-related markers such as CD44, (iii) the attenuation of the STAT3/HIF1-α signaling, (iv) the down-expression of uPAR and PAI-1, (v) the loss of mitochondrial membrane potential and reduced intracellular ATP production, (vi) the increase of caspase-3 activity, and (vii) the suppression of TLR4/NF-кB signaling. Therefore, we conclude that casein could be an effective adjuvant for cancer treatment.
The effect of psychotherapeutic interventions on posttraumatic stress disorder symptoms, depression and self-esteem in women exposed to violence: a systematic review and meta-analysis
Authors: Emirza Elif Güzide , Uzun Sevda 
Published: July 2024

AbstractThis study aimed to reveal the level of effect of psychotherapeutic interventions on post-traumatic stress disorder symptoms, depression, and self-esteem in women who had been exposed to violence. For this systematic review and meta-analysis study, PubMed, Web of Science, EBSCOhost, Google Scholar, and YÖK Thesis Center databases were searched without any year limitation in August-December 2022, and 28 studies were included. The data were synthesized using meta-analysis and narrative methods. This systematic review and meta-analysis found that psychotherapeutic interventions for women exposed to violence were effective on post-traumatic stress disorder symptoms in individuals (SMD: -0,590, %95 CI: -0,893- 0.196; Z= -2,937, p = 0.003, I2= %93,59). Psychotherapeutic interventions had a significant effect on women’s depression levels in favor of the intervention group, and there was high heterogeneity between the studies (SMD: -0,475, %95 CI: -0,838- 0.113; Z= -2,569, p = 0.010, I2= %90,68). Subgroup analyses showed that cognitive behavioral therapy was effective in the treatment of intimate partner violence. It was also found that psychotherapeutic interventions did not affect women’s self-esteem levels. Psychotherapeutic therapies for women who have experienced violence have a favorable impact on them and improve their mental health.