bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Activity and Mortality Among Middle-Aged and Older Adults in the United States
Authors: Wen Ming , Li Lifeng , Su Dejun 
Published: February 2014

Background:Physical activity (PA) has been routinely linked to lower all-cause mortality, yet extant research in the United States is primarily based on nonrepresentative samples. Evidence is scant on the relative and independent merits of leisure-time (LTPA) versus non-leisure-time (NLTPA) activities and how the PA-mortality link may vary across racial-ethnic-gender groups.Methods:Data were from Health and Retirement Study which began in 1992 collecting data on individuals aged 51–61 years who were subsequently surveyed once every 2 years. The current study assessed group-specific effects of LTPA and NLTPA measured in 1992 on mortality that occurred during the 1992–2008 follow-up period. Cox proportional hazard analyses were performed to examine the PA-mortality link.Results:Net of a wide range of controls, both LTPA and NLTPA showed a gradient negative relation with mortality. No gender-PA interaction effects were evident. Some interaction effects of PA with race-ethnicity were found but they were weak and inconsistent. The mortality reduction effects of PA seemed robust across racial-ethnic-gender groups.Conclusions:Regardless of personal background, PA is a major health promoting factor and should be encouraged in aging populations. More research is needed to assess relative merits of different types and domains of PA.
Effects of Physical Activity on Breast Cancer Prevention: A Systematic Review
Authors: Gonçalves Ana Katherine , Florêncio Gilzandra Lira Dantas , de Atayde Silva Maria José Maissonnete , Cobucci Ricardo Ney , Giraldo Paulo César , Cote Nancy Michelle 
Published: February 2014

Background:Observational studies have reported an association between physical activity and breast cancer risk reduction. This study aims to evaluate the effect of physical activity on breast cancer prevention.Methods:Articles were identified through literature available on Electronic databases (Pubmed, Embase, Scielo, Cochrane, CINAHL, Cancerlit, and Google Scholar) and manual searches. Case control and cohort studies were assessed for methodological quality, using the Newcastle-Ottawa scale.Results:Size, population, components, and characteristics of physical activity, and menopausal status were documented. Review Manager 5.1 performed analysis using the statistical method of Mantel-Haenszel. Fixed-effect analysis with dichotomous data, testing subgroups and calculating odds ratio with a confidence interval of 95% were used. Main results: 7 cohort studies and 14 case control studies were evaluated. Statistical evidence found that physical activity reduces the risk of breast cancer in case-control studies [OR = 0.84 (0.81–0.88)] (heterogeneity 72%) and cohort studies [OR = 0.61 (0.59–0.63)] (heterogeneity 100%).Conclusion:Physical activity seems to prevent breast cancer mainly in postmenopausal women.
How to Motivate Childcare Workers to Engage Preschoolers in Physical Activity
Authors: Gagné Camille , Harnois Isabelle 
Published: February 2014

Background:Data available indicate that numerous childcare workers are not strongly motivated to engage children aged 3–5 in physical activity. Using the theory of planned behavior as the main theoretical framework, this study has 2 objectives: to identify the determinants of the intention of childcare workers to engage preschoolers in physical activity and to identify the variables that could be used to develop an intervention to motivate childcare workers to support preschoolers’ physical activity.Methods:174 childcare workers from 60 childcare centers selected at random in 2 regions of Quebec completed a self-administered questionnaire assessing the constructs of the theory of planned behavior as well as past behavior, descriptive norm and moral norm.Results:Moral norm, perceived behavioral control and subjective norm explained 85% of the variance in intention to engage the children in physical activity.Conclusions:To motivate childcare workers, it is necessary that they perceive that directors, children’s parents and coworkers approve of their involvement in children’s physical activity. In addition, their ability to overcome perceived barriers (lack of time, loaded schedule, inclement weather) should be developed. Access to a large outdoor yard might also help motivate childcare workers.
Peer Influence and Physical Activity Behavior in Young Children: An Experimental Study
Authors: Barkley Jacob Edward , Salvy Sarah-Jeanne , Sanders Gabriel J. , Dey Shounak , Von Carlowitz Kyle-Patrick , Williamson Megan L. 
Published: February 2014

Background:There is evidence that the presence of a friend increases physical activity behavior in schoolaged children (≥ 8 years old) and in young adolescents. Little is known about the developmental trajectory of the effects of peer influences on children’s physical activity. Therefore, we sought to test the effect of the presence versus absence of a friend on physical activity in young children (≤ 6 years old).Methods:Physical activity was assessed, via accelerometery, in 3- to 6-year-old children, during 2 social conditions: alone and in the presence of a friend. During each condition, children were taken to a gymnasium and had free access to physical and sedentary activities for 30 minutes. In one condition children were tested alone (solo play), whereas in the other they were tested in the presence of a friend who had access to the same activities.Results:Children exhibited 54% greater (P < .02) average accelerometer counts during the friend condition (mean = 2629, SD = 1080 or 5.7 METs) than during the solo play condition (mean = 1707, SD = 1009 or 4.5 METs).Conclusions:The presence of a friend contributes to increased physical activity behavior in young children.
Association of Leisure-Time Physical Activity With Cardiorespiratory Fitness in Indian Men
Authors: Singhal Neha , Siddhu Anupa 
Published: February 2014

Background:The relationship between leisure-time physical activity (LTPA) and cardiorespiratory fitness (CRF) is not clearly understood in Indian men. It is important to elucidate whether the duration or intensity of LTPA is responsible for increasing CRF. This will help in designing better physical activity intervention strategies for improving CRF in Indian men.Methods:Healthy nondiabetic urban Indian men with no history of coronary heart disease (CHD) were selected (n = 603; aged 22–64 years) and their energy intake and physical activity was determined using a questionnaire. Body fat (percent) was determined by leg-to-leg bioelectrical impedance analysis while CRF was measured on multistage, continuous treadmill test using Bruce protocol.Results:Intensity of physical activity (METs) emerged as the best independent predictor of CRF (β = 0.217; P < .001). Using univariate General Linear Model, it was found that CRF is more a function of LTPA intensity than LTPA duration, since LTPA duration was not related to CRF when controlled for LTPA intensity. However, LTPA intensity remained significantly associated with CRF even after adjustment for LTPA duration.Conclusion:LTPA of preferably higher intensity should be incorporated in the lifestyle to improve CRF and prevent CHD in Indian men.
Effects of Ready for Recess, An Environmental Intervention, on Physical Activity in Third-Through Sixth-Grade Children
Authors: Huberty Jennifer L. , Beets Michael W. , Beighle Aaron , Saint-Maurice Pedro F. , Welk Greg 
Published: February 2014

Background:The purpose of this study was to determine the effectiveness of Ready for Recess, an elementary school recess intervention targeting staff training (ST) or providing recreational equipment (EQ) separately, and the combination (EQ+ST) on physical activity (PA).Methods:Participants were children attending 1 of 12 elementary schools (grades 3rd–6th) included in the study. Separate analytical models were used to evaluate the effects of the intervention conditions on children’s accelerometry and direct observation derived PA measures.Results:Boys and girls were measured using accelerometry (n = 667). Boys in EQ+ST increased their MVPA by 14.1% while ST decreased their MVPA by –13.5%. Girls in ST decreased their MVPA by –11.4%. Neither boys nor girls in EQ increased their time spent in MVPA. A total of 523 (boys) and 559 (girls) observations were collected. For boys’ and girls’ sedentary and vigorous activity there were no significant main effects for treatment condition, time, or treatment condition-by-time effects.Conclusions:Environmental modifications are only as strong as the staff that implements them. Supervision, if not interactive, may be detrimental to PA participation, especially in girls. Research related to staff training for encouragement and promotion of PA coupled with appropriate use of equipment during recess is warranted.
Regions of Mid-level Human Visual Cortex Sensitive to the Global Coherence of Local Image Patches
Authors: Mannion Damien J. , Kersten Daniel J. , Olman Cheryl A. 
Published: February 2014

AbstractThe global structural arrangement and spatial layout of the visual environment must be derived from the integration of local signals represented in the lower tiers of the visual system. This interaction between the spatially local and global properties of visual stimulation underlies many of our visual capacities, and how this is achieved in the brain is a central question for visual and cognitive neuroscience. Here, we examine the sensitivity of regions of the posterior human brain to the global coordination of spatially displaced naturalistic image patches. We presented observers with image patches in two circular apertures to the left and right of central fixation, with the patches drawn from either the same (coherent condition) or different (noncoherent condition) extended image. Using fMRI at 7T (n = 5), we find that global coherence affected signal amplitude in regions of dorsal mid-level cortex. Furthermore, we find that extensive regions of mid-level visual cortex contained information in their local activity pattern that could discriminate coherent and noncoherent stimuli. These findings indicate that the global coordination of local naturalistic image information has important consequences for the processing in human mid-level visual cortex.
The Moon Illusion and Size–Distance Scaling—Evidence for Shared Neural Patterns
Authors: Weidner Ralph , Plewan Thorsten , Chen Qi , Buchner Axel , Weiss Peter H. , Fink Gereon R. 
Published: February 2014

Abstract
A moon near to the horizon is perceived larger than a moon at the zenith, although—obviously—the moon does not change its size. In this study, the neural mechanisms underlying the “moon illusion” were investigated using a virtual 3-D environment and fMRI. Illusory perception of an increased moon size was associated with increased neural activity in ventral visual pathway areas including the lingual and fusiform gyri. The functional role of these areas was further explored in a second experiment. Left V3v was found to be involved in integrating retinal size and distance information, thus indicating that the brain regions that dynamically integrate retinal size and distance play a key role in generating the moon illusion.
The Effect of FEF Microstimulation on the Responses of Neurons in the Lateral Intraparietal Area
Authors: Premereur Elsie , Vanduffel Wim , Janssen Peter 
Published: February 2014

Abstract
The macaque FEFs and the lateral intraparietal area (LIP) are high-level cortical areas involved in both spatial attention and oculomotor behavior. Stimulating FEF at a level below the threshold for evoking saccades increases fMRI activity and gamma power in area LIP, but the precise effect exerted by the FEF on LIP neurons is unknown. In our study, we recorded LIP single-unit activity during a visually guided saccade task with a peripherally presented go signal during microstimulation of FEF. We found that FEF microstimulation increased the LIP spike rate immediately after the highly salient go signal inside the LIP receptive field when both target and go signal were presented inside the receptive field, and no other possible go cues were present on the screen. The effect of FEF microstimulation on the LIP response was positive until at least 800 msec after microstimulation had ceased, but reversed for longer trial durations. Therefore, FEF microstimulation can modulate the LIP spike rate only when attention is selectively directed toward the stimulated location. These results provide the first direct evidence for LIP spike rate modulations caused by FEF microstimulation, thus showing that FEF activity can be the source of top–down control of area LIP.
A Functional Polymorphism of the MAOA Gene Is Associated with Neural Responses to Induced Anger Control
Authors: Denson Thomas F. , Dobson-Stone Carol , Ronay Richard , von Hippel William , Schira Mark M. 
Published: February 2014

Abstract
Aggressiveness is highly heritable. Recent experimental work has linked individual differences in a functional polymorphism of the monoamine oxidase-A gene (MAOA) to anger-driven aggression. Other work has implicated the dorsal ACC (dACC) in cognitive-emotional control and the amygdala in emotional arousal. The present imaging genetics study investigated dACC and amygdala reactivity to induced anger control as a function of MAOA genotype. A research assistant asked 38 healthy male undergraduates to control their anger in response to an insult by a rude experimenter. Men with the low-expression allele showed increased dACC and amygdala activation after the insult, but men with the high-expression allele did not. Both dACC and amygdala activation independently mediated the relationship between MAOA genotype and self-reported anger control. Moreover, following the insult, men with the high-functioning allele showed functional decoupling between the amygdala and dACC, but men with the low-functioning allele did not. These results suggest that heightened dACC and amygdala activation and their connectivity are neuroaffective mechanisms underlying anger control in participants with the low-functioning allele of the MAOA gene.
Spatiotemporal Dynamics of Online Motor Correction Processing Revealed by High-density Electroencephalography
Authors: Dipietro Laura , Poizner Howard , Krebs Hermano I. 
Published: February 2014

Abstract
The ability to control online motor corrections is key to dealing with unexpected changes arising in the environment with which we interact. How the CNS controls online motor corrections is poorly understood, but evidence has accumulated in favor of a submovement-based model in which apparently continuous movement is segmented into distinct submovements. Although most studies have focused on submovements' kinematic features, direct links with the underlying neural dynamics have not been extensively explored. This study sought to identify an electroencephalographic signature of submovements. We elicited kinematic submovements using a double-step displacement paradigm. Participants moved their wrist toward a target whose direction could shift mid-movement with a 50% probability. Movement kinematics and cortical activity were concurrently recorded with a low-friction robotic device and high-density electroencephalography. Analysis of spatiotemporal dynamics of brain activation and its correlation with movement kinematics showed that the production of each kinematic submovement was accompanied by (1) stereotyped topographic scalp maps and (2) frontoparietal ERPs time-locked to submovements. Positive ERP peaks from frontocentral areas contralateral to the moving wrist preceded kinematic submovement peaks by 220–250 msec and were followed by positive ERP peaks from contralateral parietal areas (140–250 msec latency, 0–80 msec before submovement peaks). Moreover, individual subject variability in the latency of frontoparietal ERP components following the target shift significantly predicted variability in the latency of the corrective submovement. Our results are in concordance with evidence for the intermittent nature of continuous movement and elucidate the timing and role of frontoparietal activations in the generation and control of corrective submovements.
The Neural Coding of Feedback Learning across Child and Adolescent Development
Authors: Peters Sabine , Braams Barbara R. , Raijmakers Maartje E. J. , Koolschijn P. Cédric M. P. , Crone Eveline A. 
Published: February 2014

Abstract
The ability to learn from environmental cues is an important contributor to successful performance in a variety of settings, including school. Despite the progress in unraveling the neural correlates of cognitive control in childhood and adolescence, relatively little is known about how these brain regions contribute to learning. In this study, 268 participants aged 8–25 years performed a rule-learning task with performance feedback in a 3T MRI scanner. We examined the development of the frontoparietal network during feedback learning by exploring contributions of age and pubertal development. The pFC showed more activation following negative compared with positive feedback with increasing age. In contrast, our data suggested that the parietal cortex demonstrated a shift from sensitivity to positive feedback in young children to negative feedback in adolescents and adults. These findings were interpreted in terms of separable contributions of the frontoparietal network in childhood to more integrated functions in adulthood. Puberty (testosterone, estradiol, and self-report) did not explain additional variance in neural activation patterns above age, suggesting that development of the frontoparietal network occurs relatively independently from hormonal development. This study presents novel insights into the development of learning, moving beyond a simple frontoparietal immaturity hypothesis.
Cytotaxonomic Study of Hypodematium (Hypodematiaceae) from China
Authors: Wang Renxiang , Shao Wen , Liu Ling 
Published: February 2014

Chromosome numbers and reproductive biology of nine species of the fern genus Hypodematium (Hypodematiaceae) from China were investigated. The chromosome numbers of eight species are reported here for the first time: H. daochengensis n=41 (41 II); H. fordii n=40 (40 II), n=80 (40 II+40 I), 2n=120; H. glanduloso-pilosum n=41 (41 II), 2n=82, 2n=123; H. gracile n=41 (41 II); H. hirsutum n= 41 (41 II); H. microleptoides n=41 (41 II); H. sinense n= 40 (40 II) and H. squamuloso-pilosum n=41 (41 II). Two cytotypes, n=82 (41 II+41 I) and 2n=123 in H. crenatum, are reported for the first time. Our results showed that the species with these cytotypes are agamospermous triploids: H. crenatum n = 82 (41 II +41 I), H. glanduloso-pilosum n = 82 (41 II +41 I) and H. fordii n = 80 (40 II +40 I), based on the unequal size and presence of aborted spores in the sporangium, and the allotriploid hybrid chromosomes in the spore mother cell at the diakinesis stage of meiosis I. The remaining species are sexual diploids and tetraploids, based on the chromosome number n = 41 and n =82 at the diakinesis stage of meiosis I of spore mother cells. The relationships among habitat preferences, frond hairs and reproductive modes in Hypodematium are discussed and illustrated. It appears that plants with large fronds and sparse, thin hairs, living in humid and shady places undergo sexual reproduction, while small plants living in sunny and dry conditions with thick hairs undergo agamospermous reproduction. The distribution pattern and basic chromosome number all indicated the basic chromosome number x= 41 was plesiomorphic, whereas x=40 was apomorphic. Chromosome aneuploid changes occurred in this genus. The distribution of the sexual diploids and tetraploids and agamospermous triploids suggests that the genus might have originated in the Himalayas and dispersed from there to northeast Asia and Japan.
Influence of the Reflected Rossby Waves on the Western Arabian Sea Upwelling Region
Authors: Tozuka Tomoki , Nagura Motoki , Yamagata Toshio 
Published: February 2014

Abstract
The sea surface temperature (SST) in the western Arabian Sea upwelling region is known to influence the amount of precipitation associated with the Indian summer monsoon. Thus, understanding what determines the SST in this region is an important issue. Using outputs from an ocean general circulation model with and without strong damping in the eastern equatorial Indian Ocean, this study examines how the reflection of semiannual Kelvin waves at the eastern boundary of the Indian Ocean may influence the western Arabian Sea upwelling region. The downwelling Kelvin waves generated in boreal spring are reflected at the eastern boundary and reach the western equatorial Indian Ocean as reflected Rossby waves about 6 months later. The resulting westward current along the equator in the western equatorial Indian Ocean transports warmer water to the western Arabian Sea upwelling region. Thus, the SST in this region becomes colder especially in boreal fall without the reflected Rossby waves. These results are further supported by the analysis of the mixed layer temperature balance. Surprisingly, vertical processes do not contribute to the SST difference, even though the thermocline becomes shallower without the downwelling Rossby waves. This is because the mixed layer is shoaling rapidly from September to November, and there is basically no entrainment of water from below. In contrast, the reflected Rossby waves do not have large impacts on the SST in other seasons mainly because the zonal SST gradient is not as strong and/or the amplitude of Rossby waves is weaker.
A pipeline to extract drug-adverse event pairs from multiple data sources
Authors: Yeleswarapu SriJyothsna , Rao Aditya , Joseph Thomas , Saipradeep Vangala Govindakrishnan , Srinivasan Rajgopal 
Published: February 2014

Abstract

Background
Pharmacovigilance aims to uncover and understand harmful side-effects of drugs, termed adverse events (AEs). Although the current process of pharmacovigilance is very systematic, the increasing amount of information available in specialized health-related websites as well as the exponential growth in medical literature presents a unique opportunity to supplement traditional adverse event gathering mechanisms with new-age ones.

Method
We present a semi-automated pipeline to extract associations between drugs and side effects from traditional structured adverse event databases, enhanced by potential drug-adverse event pairs mined from user-comments from health-related websites and MEDLINE abstracts. The pipeline was tested using a set of 12 drugs representative of two previous studies of adverse event extraction from health-related websites and MEDLINE abstracts.

Results
Testing the pipeline shows that mining non-traditional sources helps substantiate the adverse event databases. The non-traditional sources not only contain the known AEs, but also suggest some unreported AEs for drugs which can then be analyzed further.

Conclusion
A semi-automated pipeline to extract the AE pairs from adverse event databases as well as potential AE pairs from non-traditional sources such as text from MEDLINE abstracts and user-comments from health-related websites is presented.