bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose-escalated Hypofractionated Intensity-modulated Radiation Therapy With Concurrent Chemotherapy for Inoperable or Unresectable Non-Small Cell Lung Cancer
Authors: Kim Julian O. , Chu Karen P. , Fairchild Alysa , Ghosh Sunita , Butts Charles , Chu Quincy , Gabos Zsolt , Joy Anil A. , Nijjar Tirath , Robinson Donald M. , Sangha Randeep , Scrimger Rufus , Smylie Micheal , Yee Don , Roa Wilson H. 
Published: October 2014

Purpose:
The local control of inoperable non-small cell lung cancer (NSCLC) using standard radiotherapy (RT) doses is inadequate. Dose escalation is a potential strategy to improve the local control for patients with NSCLC; however, the optimal dose required for local control in this setting is unknown.

Methods and Materials:
Patients with unresectable or inoperable stage II/III NSCLC with ECOG≤1 received 48 Gy in 20 daily fractions using intensity-modulated radiotherapy, followed by 1 of 3 boost dose levels: 16.8 Gy/7 (cumulative 2 Gy equivalent dose [EQD2]≅76 Gy/38), 20.0 Gy/7 (EQD2≅84 Gy/42), and 22.7 Gy/7 (EQD2≅92 Gy/46). Two cycles of cisplatin/etoposide chemotherapy were given concurrent with RT. The maximum tolerated dose was defined as the dose at which ≥30% experienced dose-limiting toxicity (any NCIC Common Terminology for Adverse Events V3.0 grade 3 or higher acute toxicity).

Results:
Twelve patients completed treatment with a median follow-up of 22 months (range, 7 to 48). The median age was 72 (range, 54 to 80) and 50% of patients had adenocarcinoma. Five, 3, and 4 patients were treated on dose levels 1, 2, and 3, respectively. No dose-limiting toxicity was observed. One-year local progression-free survival and overall survival estimates were 81% and 58%, respectively.

Conclusions:
Hypofractionated intensity-modulated radiotherapy was well tolerated and provided meaningful local control for patients with locally advanced inoperable NSCLC. The maximum tolerated dose of RT in this setting lies beyond an EQD2 of 92 Gy/46 and further dose escalation in this setting is warranted.
Older Patients With Early-stage Breast Cancer
Authors: Nagar Himanshu , Yan Weisi , Christos Paul , Chao K.S. Clifford , Nori Dattatreyudu , Ravi Akkamma 
Published: October 2014

Purpose:
Studies have shown that older women are undertreated for breast cancer. Few data are available on cancer-related death in elderly women aged 70 years and older with pathologic stage T1a-b N0 breast cancer and the impact of prognostic factors on cancer-related death.

Methods:
The Surveillance, Epidemiology, and End Results (SEER) database was queried for women aged 70 years or above diagnosed with pT1a or pT1b, N0 breast cancer who underwent breast conservation surgery from 1999 to 2003. The Kaplan-Meier survival analysis was performed to evaluate breast cause-specific survival (CSS) and overall survival (OS), and the log-rank test was employed to compare CSS/OS between different groups of interest. Multivariable analysis (MVA), using Cox proportional hazards regression analysis, was performed to evaluate the independent effect of age, race, stage, grade, ER status, and radiation treatment on CSS. Adjusted hazard ratios were calculated from the MVA and reflect the increased risk of breast cancer death. Competing-risks survival regression was also performed to adjust the univariate and multivariable CSS hazard ratios for the competing event of death due to causes other than breast cancer.

Results:
Patients aged 85 and above had a greater risk of breast cancer death compared with patients aged 70 to 74 years (referent category) (adjusted hazard ratio [HRs]=1.98). Race had no effect on CSS. Patients with stage T1bN0 breast cancer had a greater risk of breast cancer death compared with stage T1aN0 patients (adjusted HR=1.35; P=0.09). ER negative patients had a greater risk of breast cancer death compared with ER positive patients (adjusted HR=1.59; P<0.017). Patients with higher grade tumors had a greater risk of breast cancer death compared with patients with grade 1 tumors (referent category) (adjusted HRs=1.69 and 2.96 for grade 2 and 3, respectively). Patients who underwent radiation therapy had a lower risk of breast cancer death compared with patients who did not (adjusted HR=0.55; P<0.0001).

Conclusions:
Older patients with higher grade, pT1b, ER-negative breast cancer had increased risk of breast cancer-related death. Adjuvant radiation therapy may provide a CSS benefit in this elderly patient population.
Cooperative development of logical modelling standards and tools with CoLoMoTo
Authors: Naldi Aurélien , Monteiro Pedro T. , Müssel Christoph ,   the Consortium for Logical Models and Tools, Kestler Hans A. , Thieffry Denis , Xenarios Ioannis , Saez-Rodriguez Julio , Helikar Tomas , Chaouiya Claudine 
Published: October 2014

AbstractThe identification of large regulatory and signalling networks involved in the control of crucial cellular processes calls for proper modelling approaches. Indeed, models can help elucidate properties of these networks, understand their behaviour, and provide (testable) predictions by performing in silico experiments. In this context, qualitative, logical frameworks have emerged as relevant approaches as demonstrated by a growing number of published models, along with new methodologies and software tools. This productive activity now requires a concerted effort to ensure model reusability and interoperability between tools. Here, we outline the logical modelling framework and present the most important achievements of theConsortium forLogicalModels andTools, along with future objectives. This open community welcomes contributions from all researchers interested in logical modelling or in related mathematical and computational developments.
A re-design of undergraduate medical training in intellectual disability: building psychological capital and imparting knowledge to redress health inequalities
Authors: Harwood Ian , Hassiotis Angela 
Published: October 2014

Purpose
– Over 1,250 people with intellectual disabilities die unnecessarily every year in NHS care. The purpose of this paper is to develop higher-order learning amongst medical students to increase engagement with this disadvantaged group and redress this injustice in care provision.

Design/methodology/approach
– The Psychiatry of Intellectual Disability input to University College London's (UCL) undergraduate medicine MBBS curriculum was re-designed. Materials were developed to broaden the students’ understanding of the stigma and health implication of intellectual disability and the affect it has on the care received by these patients. These were delivered in lecture and e-learning formats. The concept of psychological capital was used to frame the development of new materials with direct involvement of service users with intellectual disability. It is a management model designed to promote higher levels of learning, resulting in a deeper understanding of patient issues by UCL medical graduates.

Findings
– Findings from the online survey that accompanies the e-learning materials suggests that students have overwhelmingly adopted a positive outlook towards patients with intellectual disability and consider training necessary for all doctors. The filmed scenarios with people with intellectual disability appealed to students.

Practical implications
– The broadening of the educational materials required a re-design of the methods of curriculum delivery, a higher level of self-directed learning and student time commitment. Further assessments of the impact of the module are planned to include formative assessments of learning.

Social implications
– Medical lack of knowledge, personal attitudes and a reluctance to engage with people with intellectual disability have been identified as barriers to their receiving appropriate care.

Originality/value
– A blend of organisational change theories has been integrated into the production of a new, multi-media, e-learning package.
Training and developing staff in general hospitals: intellectual disability liaison nurses and the RAID model
Authors: Walsh Nick , Handley Tricia , Hall Ian 
Published: October 2014

Purpose
– The purpose of this paper is to address the serious problems that people with intellectual disability face in getting their healthcare needs met in general hospitals by improving the training of general hospital staff.

Design/methodology/approach
– Review of recent developments in models of service provision including the development of intellectual disability liaison nurses and the RAID model in liaison psychiatry.

Findings
– There is much scope for intellectual disability liaison nurses and liaison psychiatry services to work together in staff training in general hospitals. There is a clear strategic role for both services in convincing the management of general hospitals to implement such training using economic and quality arguments.

Originality/value
– The authors suggest a new model of working to improve the healthcare outcomes of people with intellectual disabilities through effective training of staff in general hospitals.
Involving people with intellectual disabilities in the assessment of healthcare professionals
Authors: Soni Sujata , Hall Ian , Doulton Phill , Bowie Peter 
Published: October 2014

Purpose
– It is widely recognised that people with intellectual disabilities receive a poorer quality of healthcare than their non-disabled counterparts. Training for healthcare professionals in intellectual disability is often scant or non-existent. The purpose of this paper is to explore the usefulness of employing actors with intellectual disabilities as simulated patients in the assessment of trainee psychiatrists.

Design/methodology/approach
– The development of a structured clinical exam “station” designed to assess the ability of trainee psychiatrists to communicate with a simulated patient played by an actor with an intellectual disability is described. The paper also assesses the potential benefits of this kind of assessment and the experience of actors and examiners taking part in this process.

Findings
– The station was found to perform well in discriminating between candidates of various abilities and was well received by actors, examiners and observers. The station is now routinely used in the formal assessment of trainee psychiatrists.

Practical implications
– The use of people with intellectual disabilities in training and assessment appears to be advantageous in terms of improving knowledge, attitudes and skills amongst healthcare professionals and gives increased opportunities for people with intellectual disabilities to undertake valued social roles.

Originality/value
– Few institutions currently employ actors with intellectual disabilities as simulated patients as part of their training programmes and as a result there is little in the way of literature on this subject. This paper describes an alternative approach to teaching and assessment which falls in line with recommendations from the Department of Health to involve service users in the training of healthcare professionals.
Career success: fit or marketability?
Authors: Y. Haines Victor , Hamouche Salima , Saba Tania 
Published: October 2014

Purpose– In response to the conclusions of a meta-analysis of career success studies (Nget al., 2005), the purpose of this paper is to expand the range of variables being examined as predictors of career success by weaving the person-organization fit and external marketability perspectives into current career success frameworks.Design/methodology/approach– A survey was administered in partnership with an association of human resource professionals located in Canada. The questionnaire was transmitted electronically to human resource professionals. The final sample included 546 full-time, permanent, human resource professionals from multiple organizations.Findings– Confirmatory factor analysis supported the measurement model. In the final structural model, external marketability exerted a significant direct effect on career success. Person-organization fit was strongly associated with organizational sponsorship. Organizational sponsorship, in turn, exerted a significant effect on subjective career success.Originality/value– This study contrasted and tested two theoretical perspectives on career success. The mediated indirect association between person-organization fit and career success provided support for the rationale of the sponsored mobility model of social advancement. The direct association between external marketability and career success suggests that success can be achieved even without organizational sponsorship on the basis of expressions of one’s human capital.
Religiousness in times of job insecurity: job demand or resource?
Authors: Schreurs Bert , van Emmerik Hetty , De Cuyper Nele , Probst Tahira , van den Heuvel Machteld , Demerouti Eva 
Published: October 2014

Purpose– Departing from the job demands resources model, the purpose of this paper is to investigate whether religion, defined as strength of religious faith, can be viewed as resource or as demand. More specifically, the authors addressed the question as to how job insecurity and religion interact in predicting burnout and change-oriented behavior.Design/methodology/approach– The authors conducted moderated structural equation modeling on survey data from a sample of 238 employees confronted with organizational change.Findings– Results were largely consistent with the “religion as a demand” hypothesis: religion exacerbated rather than buffered the negative effects of job insecurity, so that the adverse impact of job insecurity was stronger for highly religious employees than for employees with low levels of religiousness. Religious employees appear to experience more strain when faced with the possibility of job loss.Originality/value– The results of this study challenge and extend existing knowledge on the role of religion in coping with life stressors. The dominant view has been that religion is beneficial in coping with major stressors. The results of this study, however, suggest otherwise: religion had an exacerbating rather than a buffering effect on the relationship between job insecurity and outcomes.
The role of chronological age and work experience on emotional labor
Authors: Hur Won-Moo , Moon Tae-Won , Han Su-Jin 
Published: October 2014

Purpose– The purpose of this paper is to investigate how chronological age and work experience affect emotional labor strategies (i.e. deep acting and surface acting) through emotional intelligence (EI).Design/methodology/approach– Structural equation modeling analysis provided support for the hypotheses based on a sample of 256 flight attendants working for four South Korean airlines.Findings– The results showed that chronological age has a positive effect on both surface and deep acting. The study also found that work experience has a negative influence on surface acting, whereas it has a non-significant effect on deep acting. In addition, the investigation suggests that EI mediates the relationship between work experience and deep acting.Originality/value– The current study will add to the growing body of research on emotional labor by examining the effect of chronological age and work experience on emotional labor strategies through EI.
An assessment of land use sources of barriers and the community-based housing model in the UK
Authors: Ayoade Oladotun , Ahmed Vian 
Published: October 2014

Purpose
– The aim of this study is to define land use policy sources of barriers to community-based housing options in practice.

Design/methodology/approach
– The paper accentuated the need to tackle land use sources of barrier to Community Land Trust (CLT) performance, through text analysis of semi-structured interview responses from key stakeholders.

Findings
– This study found out that there is a need to ameliorate stakeholder approach to community-based housing (CBH), which is hampered by restrictive land use sources of barriers that occur in an urban and rural context. These barriers were found to include both planning inadequacies and a systemic inefficient network of knowledge transfer practices between stakeholders. Recommendations include the need for drastic policy intervention through the political willingness to address Section 106 shortcomings in the choice of affordable housing supply models, and the inaccessibility of land below market rate in an endogenous prescriptive planning system.

Practical implications
– This paper highlights the subjective limitations of the CLT model in regards to grey areas between setting boundaries to what is an acceptable level of concessions to CBH and the socio-economic impact or benefits of a completely deregulated social housing system. These boundaries do vary from system to system, hence the need for UK housing institutions to address identified inherent barrier sources and their reconciliation with international best practices. Therefore, greater roles can be accorded to the CLT model in the UK affordable housing dynamics based on its confirmed strengths and merits.

Originality/value
– This paper adds to literature through the practical identification and interpretation of various key stakeholder perspectives on sources of CLT barriers and an idealised strategy to tackling them accordingly. This contributes to the housing affordability debate on the viability of CBH options, and how it could be invariably hampered by direct and indirect effects of planning and restrictive land use policies in practice.
Marketing strategies in the Istanbul housing market
Authors: Çinar Candan 
Published: October 2014

Purpose
– The purpose of this study is to demonstrate whether the leading argument of construction firms, which have been active in the mass production of housing for the past 10 years in Istanbul, that in addition to the features of the house itself, the position of the house in the city, in other words its location, the new lifestyles the house offers and the social reinforcements the house provides are of great significance is valid or not. This was done by analyzing the contents of the advertising copies of houses present in the printed media.

Design/methodology/approach
– In this study, the printed advertising copies of the projects realized by the mass housing construction firms which have carried out at least six projects in Istanbul housing market, have been analyzed and assessed by “content analysis”, one of the qualitative research methods of social sciences. As it can be observed from the results of the analysis, the house, while being regarded as a product and marketed via its features, also has become a product presented to the consumer as a result of its position in the city, in other words its location, the new lifestyles it offers and the social reinforcements it provides.

Findings
– As this study has demonstrated, marketing strategies based on attracting the attention of the customer by making use of means of communication are also valid for housing in Istanbul housing market. Housing is marketed not only according to its features as a product but also according to the urban area where it is situated, new lifestyles and social reinforcements it presents. In this marketing process, the features of the housing itself; its size, construction technology, quality of the fine materials, earthquake resistance, etc. as well as the urban area where the housing is situated, the location of it, opportunities of infrastructure and superstructure of the housing become the foregrounded arguments in the advertising copies.

Originality/value
– This study is that, as a requirement of modern-day marketing, the consumption relation of the consumer to the house is not simply based on the features of the house, that modern-day marketing tries to capture the attention of the consumer via the position of the house in the city (location), which is the equivalent of the other symbolic values associated with the house, the lifestyles it presents and the social reinforcements it provides.
Production and production over-supply in construction: estimating unsold stock in Italy
Authors: Ciaramella Andrea , Celani Alberto 
Published: October 2014

Purpose
– The aim of the article is to identify the limitations and critical issues in the way information in the real estate sector in Italy is currently managed, and propose the principles of a method that would provide information and comparison of the phenomenon of over-supply and non-rational land use. This study is based on a series of assumptions, the first of which is a definition of “unsold”, deemed to mean “the amount of new housing units neither occupied nor sold nor rented”. In effect, unsold stock can be considered as over-supply of construction.

Design/methodology/approach
– The article identifies the critical aspects in the determination of unsold real estate in Italy, starting from the available data and research already carried out; the results are often contradictory. The comparison with programming systems of building production adopted in other countries allows identification of the guidelines that can be used to better understand and combat the phenomenon.

Findings
– The assessment of the state -of-the-art provides a clear picture of the shortcomings and potential of the tools used to date to meet the need of studying a complex phenomenon with many obscure points. Following the empirical analysis comes out a picture of inefficiencies due to the poor quality of information, as well as the reluctance of data-sharing and -integration procedures by the institutional and market players.

Research limitations/implications
– The research produces solutions addressed to the Italian situation, but it identifies systems and methods used in other countries.

Practical implications
– The article suggests the collection systems and management information that can be used for a more accurate knowledge of unsold real estate.

Social implications
– The article focuses on some of the limits of the Italian real estate market, highlighting the need for greater transparency and how this can contribute to a more conscious approach to the market.

Originality/value
– The article seeks to provide the necessary answers to those who must understand the reasons of harmful effects for the market, such as overproduction; besides some models focused on three areas – the procedures, the organization and the market – are also proposed.
Violence, fear and anti-violence: the Batek of Peninsular Malaysia
Authors: Tacey Ivan , Riboli Diana 
Published: October 2014

Purpose– The purpose of this paper is to identify and analyze socio-cultural and political forces which have shaped anti-violent attitudes and strategies of the Batek and Batek Tanum of Peninsular Malaysia.Design/methodology/approach– Data collection during the authors’ long-term, multi-sited ethnographic fieldwork among the Batek and Batek Tanum in Peninsular Malaysia. Methodology included participant observation, semi-structured interviews and a literature review of texts on the Orang Asli and anthropological theories on violence.Findings– Traumatic experiences of past violence and atrocities greatly influence the Batek's and Batek Tanum's present attitudes toward direct and structural forms of violence. A variety of anti-violent strategies are adopted, including the choice to escape when physically threatened. Rather than demonstrating “weakness,” this course of action represents a smart survival strategy. External violence reinforces values of internal cooperation and mutual-aid that foraging societies, even sedentary groups, typically privilege. In recent years, the Batek's increasing political awareness has opened new forms of resistance against the structural violence embedded within Malaysian society.Originality/value– The study proposes that societies cannot simply be labelled as violent or non-violent on the basis of socio-biological theories. Research into hunter-gatherer social organization and violence needs to be reframed within larger debates about structural violence. The “anti-violence” of certain foraging groups can be understood as a powerful form of resilience to outside pressures and foraging groups’ best possible strategy for survival.