bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non‐coding RNA TPT1‐AS1 inhibits ferroptosis in ovarian cancer by regulating GPX4 via CREB1 regulation
Authors: Cao Lei , Wang Yan , Liu Juanni , Bai Xiaoying , Chi Xiaohong 
Published: August 2024

AbstractBackgroundLong non‐coding RNAs (lncRNAs) play crucial roles in cellular processes, with dysregulation implicated in various diseases, including cancers. The lncRNA TPT1‐AS1 (TPT1 Antisense RNA 1) promotes tumor progression in several cancers, including ovarian cancer (OC), but its influence on ferroptosis and interaction with other proteins remains underexplored.MethodsIn this study, we employed a multi‐faceted approach to investigate the functional significance of TPT1‐AS1 in OC. We assessed TPT1‐AS1 expression in OC specimens and cell lines using RT‐qPCR, in situ hybridization (ISH), and fluorescence in situ hybridization (FISH) assays. Functional assays included evaluating the impact of TPT1‐AS1 knockdown on OC cell proliferation, migration, invasiveness, and cell cycle progression. Further, we explored and validated the interaction of TPT1‐AS1 with other proteins using bioinformatics. Finally, we investigated TPT1‐AS1 involvement in erastin‐induced ferroptosis using Iron Assay, Malondialdehyde (MDA) assay, and reactive oxygen species (ROS) detection.ResultsOur findings revealed that TPT1‐AS1 overexpression in OC correlated with an unfavorable prognosis. TPT1‐AS1 knockdown suppressed cell proliferation, migration, and invasiveness. Additionally, TPT1‐AS1 inhibited erastin‐induced ferroptosis, and in vivo experiments confirmed its oncogenic impact on tumor development. Mechanistically, TPT1‐AS1 was found to regulate Glutathione Peroxidase 4 (GPX4) transcription via CREB1 (cAMP response element‐binding protein 1) and interact with RNA‐binding protein (RBP) KHDRBS3 (KH RNA Binding Domain Containing, Signal Transduction Associated 3) to regulate CREB1.ConclusionTPT1‐AS1 promotes OC progression by inhibiting ferroptosis and upregulating CREB1, forming a regulatory axis with KHDRBS3. These findings highlight the regulatory network involving lncRNAs, RBPs, and transcription factors in cancer progression.
Bayesian analysis of multivariate mixed longitudinal ordinal and continuous data
Authors: Zhang Xiao 
Published: August 2024

SummaryMultivariate longitudinal ordinal and continuous data exist in many scientific fields. However, it is a rigorous task to jointly analyse them due to the complicated correlated structures of those mixed data and the lack of a multivariate distribution. The multivariate probit model, assuming there is a multivariate normal latent variable for each multivariate ordinal data, becomes a natural modeling choice for longitudinal ordinal data especially for jointly analysing with longitudinal continuous data. However, the identifiable multivariate probit model requires the variances of the latent normal variables to be fixed at 1, thus the joint covariance matrix of the latent variables and the continuous multivariate normal variables is restricted at some of the diagonal elements. This constrains to develop both the classical and Bayesian methods to analyse mixed ordinal and continuous data. In this investigation, we proposed three Markov chain Monte Carlo (MCMC) methods: Metropolis–Hastings within Gibbs algorithm based on the identifiable model, and a Gibbs sampling algorithm and parameter‐expanded data augmentation based on the constructed non‐identifiable model. Through simulation studies and a real data application, we illustrated the performance of these three methods and provided an observation of using non‐identifiable model to develop MCMC sampling methods.
Limiting access to assisted reproductive technologies for males of advanced age—Pros and cons from a Nordic perspective
Authors: Hanevik Hans Ivar , Bergh Christina , Laivuori Hannele , Spangmose Anne Lærke , Magnusson Åsa , Pinborg Anja , Piltonen Terhi 
Published: August 2024

AbstractIt is not controversial to state that parental age is increasing in several countries. But how to deal with this increase might be. Some Nordic countries have set an upper age limit for females seeking assisted reproduction in their national legislation, but none have done so for males. There are also recommendations in place that restrict access to publicly funded assisted reproduction for both females and males of advanced age in some Nordic countries. As recent data now show somatic and psychiatric health risks related to advanced paternal age, we ask if the time has come for countries to set an upper age limit for males seeking assisted reproduction like there already is for females, and summarize some of the risks and rewards involved in treating couples with advanced age in fertility clinics.
Agile 3+ and Agile 4 scores predict chronic kidney disease development in metabolic dysfunction‐associated steatotic liver disease
Authors: Jung Chan‐Young , Lee Jung Il , Ahn Sang Hoon , Kim Seung Up , Kim Beom Seok 
Published: August 2024

SummaryBackground and AimsDespite the development of transient elastography (TE)‐based Agile scores for diagnosing fibrotic burden in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), their applicability in predicting kidney outcomes remains unclear. We aimed to investigate the association between liver fibrotic burden, as assessed by Agile scores, and the risk of incident chronic kidney disease (CKD) in patients with MASLD.MethodsA total of 3240 participants with MASLD but without pre‐existing CKD who underwent TE between July 2006 and October 2018 were selected. The primary outcome was incident CKD, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or proteinuria (≥1+ on dipstick) on two consecutive measurements. The secondary outcome was a 25% decline in eGFR measured on two consecutive visits.ResultsDuring a median follow‐up of 3.6 years, 187 participants (5.8%) developed incident CKD. When stratified into three groups according to Agile 3+ scores, multivariable Cox models revealed that risk of incident CKD was 2.77‐fold (95% confidence interval [CI], 1.89–4.07; p < 0.001) higher in the high‐risk group (Agile 3+ >0.68), compared to the low‐risk group (Agile 3+ <0.45). During a median follow‐up of 3.4 years, the high‐risk group had a 2.41‐fold higher risk (95% CI, 1.86–3.12; p < 0.001) of experiencing the secondary outcome, compared to the low‐risk group. Similar findings were observed for Agile 4 scores. Prediction testing revealed that Agile scores were better predictors of kidney outcomes, compared to liver stiffness measured by TE.ConclusionsIn patients with MASLD, but without CKD, advanced liver fibrosis measured by Agile scores was significantly associated with a higher risk of incident CKD.
Prognostic stratification in DLBCL patients with aberrant MYC gene
Authors: Li Jian‐Rong , Shaw Vikram R. , Parthasarathy Abi , Li Yong , Amos Christopher I. , Cheng Chao 
Published: August 2024

SummaryDiffuse large B‐cell lymphoma (DLBCL) is a heterogeneous disease characterized by a subset of patients who exhibit treatment resistance and poor prognoses. Genomic assays have been widely employed to identify high‐risk individuals characterized by rearrangements in the MYC, BCL2 and BCL6 genes. These patients typically undergo more aggressive therapeutic treatments; however, there remains a significant variation in their treatment outcomes. This study introduces an MYC signature score (MYCSS) derived from gene expression profiles, specifically designed to evaluate MYC overactivation in DLBCL patients. MYCSS was validated across several independent cohorts to assess its ability to stratify patients based on MYC‐related genetic and molecular aberrations, enhancing the accuracy of prognostic evaluations compared to conventional MYC biomarkers. Our results indicate that MYCSS significantly refines prognostic accuracy beyond that of conventional MYC biomarkers focused on genetic aberrations. More importantly, we found that nearly 50% of patients identified as high risk by traditional MYC metrics actually share similar survival prospects with those having no MYC aberrations. These patients may benefit from standard GCB‐based therapies rather than more aggressive treatments. MYCSS provides a robust signature that identifies high‐risk patients, aiding in the precision treatment of DLBCL, and minimizing the potential for overtreatment.
Remembering history: Autobiographical memory for the COVID‐19 pandemic lockdowns, psychological adjustment, and their relation over time
Authors: Hjuler Tirill Fjellhaugen , Lee Daniel , Ghetti Simona 
Published: August 2024

AbstractThis longitudinal study examined age‐ and gender‐related differences in autobiographical memory about the COVID‐19 pandemic lockdowns and whether the content of these memories predicted psychological adjustment over time. A sample of 247 students (Mage = 11.94, range 8–16 years, 51.4% female, 85.4% White) was recruited from public and private schools in Denmark and assessed three times from June 2020 to June 2021. The findings showed that memories weakened over time in detail and emotional valence. Additionally, psychological well‐being decreased over time, with adolescent females faring the worst. Critically, memories including higher levels of negative affect and factual information about COVID‐19 and the lockdown predicted worse psychological well‐being over time, underscoring aspects of autobiographical memory that might help attenuate the negative consequences of the lockdown.
‘Children should be raised like this’: A history of the neurodiversity movement in Italy and its implications for children's well‐being
Authors: Scavarda Alice , Cascio M. Ariel 
Published: August 2024

AbstractChildhood Studies scholars have increasingly engaged with the concept of neurodiversity, particularly with respect to neurodivergent children's mental well‐being. The purpose of this paper is to discuss the history of the neurodiversity movement in Italy, and the consequences on children's mental health, drawing on eight in‐depth interviews with movement leaders, researchers and members of parent associations. We argue that Italian education and health services serve as promising sites within which a neurodiversity approach can foster neurodivergent children's self‐esteem and give them powerful tools to fight against oppressive practices.
Allergic contact dermatitis in adults with and without atopic dermatitis: Evaluation of the Spanish Contact Dermatitis Registry (REIDAC)
Authors: Chicharro P. , Munera‐Campos M. , Zaragoza‐Ninet V. , Giménez‐Arnau A. , González‐Pérez R. , Miquel‐Miquel F. J. , Córdoba‐Guijarro S. , Sanz‐Sánchez T. , Ruiz‐González I. , Silvestre‐Salvador J. F. , Serra‐Baldrich E. , Borrego L. , Pastor‐Nieto M. A. , Ortiz de Frutos F. J. , Mercader‐García P. , Heras‐Mendaza F. , Fernández‐Redondo V. , Rodríguez‐Serna M. , Hervella‐García M. , Carrascosa J. M. , Gallego‐Descalzo M. A. , García‐Doval I. , Sánchez‐Pérez J. 
Published: August 2024

AbstractBackgroundAtopic dermatitis (AD) and allergic contact dermatitis (ACD) are inflammatory skin conditions whose association is not clearly defined.ObjectivesTo identify differences in ACD profile between patients with and without AD among those referred for patch testing. Additionally, to determine the prevalence of sensitisation to standard Spanish contact allergens in both groups.MethodsWe analysed two groups (AD and non‐AD) within the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy (REIDAC). Contact allergy, clinical relevance and epidemiological data were compared between them.ResultsA total of 5055 patients were included. Among them, 23% (1168) had a history or final diagnosis of AD. At least one positive reaction was seen in 468 (40%) of AD patients and 1864 (48%) of non‐AD patients. In both groups, the most common positive reactions were to nickel sulphate, methylchloroisothiazolinone/methylisothiazolinone and cobalt chloride. Age‐adjusted OR for sensitisation to nickel sulphate was 0.72 (95% CI: 0.61–0.86), indicating a decreased likelihood of sensitisation in AD patients compared to non‐AD individuals.ConclusionsWe did not find an increased presence of ACD in patients with AD referred for patch testing, exhibiting similar profiles to non‐AD population, except for a negative relationship between AD and sensitisation to nickel sulphate.
Assessing contact dermatitis risk among Manitoba workers in the Manitoba Occupational Disease Surveillance System
Authors: Rydz E. , Walld R. , Quinn E. K. , Koehoorn M. W. , McLeod C. B. , Demers P. A. , Peters C. E. , Kraut A. 
Published: August 2024

AbstractIntroductionThis exploratory study aimed to assess contact dermatitis (CD) risk among workers using the Manitoba Occupational Disease Surveillance System (MODSS).MethodsThe MODSS linked accepted time‐loss claims from the Workers' Compensation Board of Manitoba (2006–2019), with administrative health data from medical and hospital records (1996–2020). CD risk by occupation and industry (hazard ratio, 95% confidence intervals) was estimated using Cox proportional hazard models, adjusted for age and stratified by sex.ResultsIncreased risk of new onset CD was observed among some occupations and industries with known skin irritants and allergens. Some occupations with known increased risks of CD remained elevated when removing the accepted WCB cases was performed, suggesting that all CD cases in these occupations may not show up in WCB statistics. Increased risk was also observed for occupations and industries with unknown exposures related to CD, whereas some groups known to be at risk of CD were not observed to have elevated risks in this cohort.DiscussionThe MODSS successfully identified some occupations and industries known to be at high risk of occupational CD, but not others. Some occupations not typically associated with work‐related CD were also identified, which warrants further investigation.
Predictive Value of Lymphocyte‐to‐Neutrophil Ratio and Platelet‐to‐Neutrophil Ratio on PD‐L1 Expression in Lung Cancer
Authors: Cui Shun‐Shun , Shen Ya , Yang Rui‐Qing 
Published: August 2024

ABSTRACTObjectiveThis study aimed to examine the predictive effect of the lymphocyte‐to‐neutrophil ratio (LNR) and the platelet‐to‐neutrophil ratio (PNR) on the expression of programmed death receptor ligand 1 (PD‐L1) in patients diagnosed with lung cancer.MethodsThe clinical records of 86 patients diagnosed with lung cancer between January 2020 and February 2022 at Fu Yang People's Hospital were retrospectively analyzed. The records included information on age, gender, smoking history, hematological indices at the time of admission, staging of the lung malignancy, histopathological subtype, comorbidities, and the expression levels of PD‐L1. Patients were stratified into two distinct cohorts based on their PD‐L1 expression levels: Those with an expression level greater than or equal to 1% were classified into the PD‐L1 positive expression group, while the remainder were categorized as the PD‐L1 negative expression group. Univariate analysis and multivariate logistic regression analysis were used to identify the influencing factors of PD‐L1, and the diagnostic efficacy was calculated using the receiver operating characteristic (ROC) curve.ResultsUpon analysis, the PD‐L1 positive expression group manifested notably lower values as compared to their counterparts in the PD‐L1 negative expression group (LNR: 0.262 ± 0.105 vs. 0.390 ± 0.201; PNR: 41.03 [29.64, 50.11] vs. 49.50 [37.38, 73.83]), and these differences were statistically significant. There was a notable disparity in PD‐L1 expression based on gender, with males exhibiting a statistically significant higher positivity rate compared to females. Furthermore, patients in Stages I–III of the disease demonstrated a markedly elevated PD‐L1 positivity rate compared to those in Stage IV (p < 0.05). Incorporating univariates with statistical differences into multivariate logistic regression analysis suggests that stage and LNR are independent risk factors for PD‐L1 negative expression. ROC curve analyses revealed that the area under the ROC curve (AUC) for LNR as an indicator for PD‐L1 positive expression stood at 0.706, while the AUC for PNR was calculated at 0.687.ConclusionPD‐L1 expression is correlated with gender and lung cancer staging, and LNR and PNR have a predictive value for PD‐L1 expression.
It Is Time to Get to Know the Neuroendocrine Cell Hyperplasia of Infancy
Authors: Jin Long , Wei Wen 
Published: August 2024

ABSTRACTIn the two decades that have elapsed since the initial proposal of neuroendocrine cell hyperplasia of infancy (NEHI), several hundred cases have been reported and researched. However, a comprehensive analysis of research progress remains absent from the literature. The present article endeavors to evaluate the current progress of NEHI research and offer a reference for the clinical management of this condition.
An interpretable machine learning methodology to generate interaction effect hypotheses from complex datasets
Authors: Nasir Murtaza , Summerfield Nichalin S. , Simsek Serhat , Oztekin Asil 
Published: August 2024

AbstractMachine learning (ML) models are increasingly being used in decision‐making, but they can be difficult to understand because most ML models are black boxes, meaning that their inner workings are not transparent. This can make interpreting the results of ML models and understanding the underlying data‐generation process (DGP) challenging. In this article, we propose a novel methodology called Simple Interaction Finding Technique (SIFT) that can help make ML models more interpretable. SIFT is a data‐ and model‐agnostic approach that can be used to identify interaction effects between variables in a dataset. This can help improve our understanding of the DGP and make ML models more transparent and explainable to a wider audience. We test the proposed methodology against various factors (such as ML model complexity, dataset noise, spurious variables, and variable distributions) to assess its effectiveness and weaknesses. We show that the methodology is robust against many potential problems in the underlying dataset as well as ML algorithms.
Do overpaid dividends drive stock price crash risk?
Authors: Ling Xiaoting , Shan Yuan George , Wu Wuqing , Zhang Lu , Zhang Xinyue 
Published: August 2024

AbstractWe explore the impact of overpaid dividends on future stock price crash risk. Using a dataset of 2662 firms with 15,416 firm‐year observations of China's A‐share listed firms, our result indicates that overpaid dividends are positively related to the likelihood of future stock price crash risk. The results further suggest that high‐quality corporate governance and financial analyst coverage can moderate the positive effect of overpaid dividends on the crash risk. Moreover, continuous overpaid dividends and state‐owned enterprises with overpaid dividends have a stronger impact on the crash risk, and overpaid dividends are significantly affected by their peer firms.
Changes in Rates of Special Considerations in Higher Education Applications Pre‐ and During the COVID‐19 Pandemic in Victoria, Australia
Authors: Gao Caroline X. , Clarke Emily , Nicholas Jennifer , Teo Shu Mei , Koppe Caleb , Peter Gavin , Lum Alex , Barth Tamara , Farish Steve , Rudd Matthew , Gong Yiting , Gan Daniel Z. Q. , Browne Vivienne , Tjia Teresa , Filia Kate M. , Killackey Eóin 
Published: August 2024

ABSTRACTBackground and AimsSince the onset of the COVID‐19 pandemic, a significant rise in mental ill health has been observed globally in young people, particularly those in their final years of secondary school. Students' negative experiences coincide with a critical transitional period which can disrupt milestones in social and educational development. This study aimed to use innovative population‐level data to map the impact of the pandemic on students entering higher education.MethodsPre‐pandemic (2019/2020) and pandemic (2020/2021) tertiary education application data were obtained from the Victorian Tertiary Admissions Centre. Prevalence of applications for special consideration related to mental ill health were compared between cohorts across various geographical areas and applicant demographic subgroups. Relative risk regression models were used to understand the role of different risk factors.ResultsRates of mental health‐related special consideration applications increased by 38% among all applications (pre‐pandemic: 7.8%, n = 56 916; pandemic: 10.8%, n = 58 260). Highest increases were observed among students in areas with both extended and close‐quarter lockdown experiences, and areas impacted by 2019/2020 black summer bushfires. The increases were higher among Year 12 students and students with other special consideration needs (e.g., physical condition, learning disability). Slightly higher increases were observed in areas with higher socio‐economic status, which may potentially be related to inequality in mental health service access.ConclusionAs consequences of mental health difficulties and academic disruption in youth can be long lasting, it is critical to establish a mental health support framework both in and outside of higher education to facilitate young people's recovery from the pandemic.
An analytical solution for vertical infiltration in homogeneous bounded profiles
Authors: Argyrokastritis I. , Kalimeris K. , Mindrinos L. 
Published: August 2024

AbstractIn this study, we derive an analytical solution to address the problem of vertical infiltration within 1D homogeneous bounded profiles. Initially, we consider the Richards equation together with Dirichlet boundary conditions. We assume constant diffusivity and linear dependence between the conductivity and the water content, resulting to a linear partial differential equation of diffusion type. To solve the simplified initial boundary value problem over a finite interval, we apply the unified transform, commonly known as the Fokas method. Through this methodology, we obtain an integral representation of the solution that can be efficiently and directly computed numerically, yielding a convergent scheme. We examine various cases, and we compare our solution with well‐known approximate solutions. This work can be seen as a first step to derive analytical solutions for the far more difficult and complex problem of modelling water flow in heterogeneous layered soils.
Cumulative adversity and survival in the wild
Authors: Ortiz‐Ross Xochitl , Blumstein Daniel T. 
Published: August 2024

AbstractProtecting populations contending with co‐occurring stressors requires a better understanding of how multiple early‐life stressors affect the fitness of natural systems. However, the complexity of such research has limited its advancement and prevented us from answering new questions. In human studies, cumulative risk models predict adult health risk based on early adversity exposure. We apply a similar framework in wild yellow‐bellied marmots (Marmota flaviventer). We tested cumulative adversity indices (CAIs) across different adversity types and time windows. All CAIs were associated with decreased pup survival and were well supported. Moderate and acute, but not standardized CAIs were associated with decreased lifespan, supporting the cumulative stress hypothesis and the endurance of early adversity. Multivariate models showed that differences in lifespan were driven by weaning date, precipitation, and maternal loss, but they performed poorly compared with CAI models. We highlight the development, utility, and insights of CAI approaches for ecology and conservation.