bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worse postoperative outcomes and higher reoperation in smokers compared to nonsmokers for arthroscopic rotator cuff repair
Authors: Gaudiani Michael A , Castle Joshua P , Jiang Eric X , Wager Susan G , Brown Spencer R , Kasto Johnny K , Gasparro Matthew A , Jurayj Alexander S , Makhni Eric C , Moutzouros Vasilios , Muh Stephanie J 
Published: July 2024

Background This study aimed to determine if smokers at the time of arthroscopic rotator cuff repair met the minimally clinical important difference and substantial clinical benefit for Patient-Reported Outcomes Measurement Information System Upper Extremity, Depression, and Pain Interference scores in comparison to nonsmoking patients in a retrospective review. Methods Clinical outcomes and Patient-Reported Outcomes Measurement Information System scores were compared between a cohort of nonsmokers and current or former smokers (smokers). Further sub-analysis compared a cohort of nonsmokers propensity-matched 1:1 to a cohort of current/former smokers via age, body mass index, and tear size. Results A total of 182 patients, 80 smokers and 102 nonsmokers, were included. Smokers had statistically different-sized tears with more rated massive ( P = 0.02) and more reoperations ( P = 0.02). Smokers met substantial clinical benefit thresholds at a lower rate than nonsmokers for Patient-Reported Outcomes Measurement Information System Upper Extremity ( P = 0.03). In the sub-analysis, 74 smokers were matched to 74 nonsmokers. Smokers had a lower change in Patient-Reported Outcomes Measurement Information System Upper Extremity ( P = 0.007) and Patient-Reported Outcomes Measurement Information System Pain Interference ( P = 0.03) postoperatively. Fewer smokers met minimally clinical important difference for Patient-Reported Outcomes Measurement Information System Upper Extremity postoperatively ( P = 0.003) and more had reoperations ( P = 0.02). Discussion Overall, smokers demonstrated smaller improvements in function, and pain, and were less likely to meet minimally clinical important differences and substantial clinical benefits for Patient-Reported Outcomes Measurement Information System Upper Extremity at 6 months follow-up when compared to nonsmokers after rotator cuff repair.
Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection
Authors: Woodcock Charlotte , Cornwall Nicola , Harrisson Sarah A , Jinks Clare , Buttery Alison , Ashworth Julie , Mallen Christian D , Dikomitis Lisa ,   on behalf of the PROMPPT team
Published: July 2024

Introduction Understanding patients’ experiences is important when developing interventions for people living with persistent pain. Interviews and focus groups are frequently used to capture beliefs, views, and perspectives. These methods often require a commitment to a predetermined date and time that may present a barrier to participation. An asynchronous online discussion forum, specifically designed for research purposes, provides an alternative and potentially more accessible method for participation. In this article we discuss a bespoke online discussion forum, the Q-PROMPPT blog, as a case example. Methods We describe how we developed the Q-PROMPPT blog, with patient and public involvement, and its use as an innovative method for qualitative data collection in the context of developing an intervention for patients prescribed opioids for persistent pain. Drawing on our experiences we discuss the following areas: planning and design, participant recruitment and registration, and participant experience and engagement. Results We identify and address key concerns for each area of the Q-PROMPPT blog: planning and design: choosing software, assigning roles, designing the interface to promote usability; recruitment of participants: recruiting eligible participants, participant anonymity; participant experience and engagement: mitigating risk of harm, facilitating discussions, planning for forum close. Conclusion Based on our lessons learnt, we outline recommendations for using a bespoke online discussion forum as a qualitative method to inform intervention development for people living with persistent pain. These include collaboration with information communication technology teams, co-design with patient and public partners, minimising risk of imposter participants and developing trust and online community identity.
A Career or a Transient Job? The Role and Development of Faculty Members in University-Based Principal Development Institutions in China
Authors: Zheng (郑玉莲) Yulian 
Published: July 2024

PurposeThis study examines the role and development of faculty members in university-based principal development institutions in China to elucidate the Chinese experience of educational leadership development and the tensions and challenges faced by the faculty of such institutions.Design/Approach/MethodsInterviews with 34 faculty members from five state-authorized university-based principal development institutions were conducted.FindingsFaculty members in principal development institutions fulfill a variety of complex, time-consuming, and taxing administrative, professional, and service responsibilities. In China, principal development institutions are affiliated with universities, and their faculty members are subject to university regulations on career sustenance and advancement. However, standards for administrative and academic promotion have no bearing on the sustainable improvement of principal development programs.Originality/ValueThis study is the first to describe the roles and development of faculty members in university-based principal development institutions in China. Knowledge of the unique structure of such programs and the experiences of faculty members may provide insights into how university-based principal training institutions can better utilize faculty to enhance program quality.
Artificial Intelligence and Education: End the Grammar of Schooling
Authors: Zhao (赵勇) Yong 
Published: July 2024

Purpose The purpose is to stimulate imagination of artificial intelligence (AI) and education beyond current schooling. Design/Approach/Methods The approach this article took is a broad review of literature on learning, teaching, schooling, and technological development and evidence-based reasoning about the possible future of education in the context of AI. Findings Schools could be transformed with the advancement of technology, especially generative AI. The changes should start with student-driven personalizing learning and problem-oriented pedagogy. Originality/Value The value of the article lies with the unique definitions of personalized learning and problem-oriented pedagogy as well as the contribution of AI to support a new form of learning.
Expanding the Middle-Income Group Through Education: Preliminary Evidence From China
Authors: Xie (谢晨) Chen , Yang (杨秀秀) Xiuxiu 
Published: July 2024

Purpose This study explores the role of education in fostering middle-income earners in China, elucidating the development and current status of the capabilities of education in this regard. This study uses the historical changes in this demographic in the United States as a frame of reference to explore future goal-setting and implementation pathways for expanding the middle-income group through education in China. Design/Approach/Methods This study uses data on variables such as income, educational attainment, and years since graduation from the China Family Panel Studies database to analyze the changing patterns in China's middle-income group regarding educational attainment. This study also uses data from the Panel Study of Income Dynamics to examine the historical changes in the middle-income group in the United States and compares the findings to those in China. Findings Results reveal the following: the changing patterns in the share of the middle-income group relative to educational attainment; the distribution of the low-, middle-, and high-income groups by educational attainment; the changing trends in the share of middle-income group by educational attainment between 2012 and 2018; and the changing trends in the share of middle- and high-income groups by educational attainment regarding the number of years since graduation. Originality/Value Rooted in and driven by current issues facing China, this study compares education in China and the United States and offers preliminary evidence of the role of education in expanding the middle-income group.
Outcomes of Patients Undergoing the Kawashima Procedure at an Early Age: A Single Center Experience
Authors: Bateson Brian P. , Files Matthew , Bohuta Lyubomyr 
Published: July 2024

Background Previous reports have demonstrated the safety and efficacy of performing early Kawashima procedure (KP). Despite this, more recent studies have shown that the average age at the time of operation remains greater than one year of age. We report our experience with performing KP at an earlier age than previously reported. Methods A retrospective review was completed of patients undergoing KP at a single center (January 2000 to June 2020). Clinical outcomes were examined. Results Initial palliation was performed in 11 out of 12 patients. Age and weight at time of KP were 8.25 months (6.4-9.7) and 7.7 kg (6.5-8.6). Intensive care unit stay was 3.16 days (1-12), overall length of stay was 9.5 days (3-22). There was one unplanned reoperation, and no mortality in the cohort. Discharge oxygen saturation was 88% (80%-98%). Seven patients developed pulmonary arteriovenous malformations (PAVMs) with six proceeding to hepatic vein incorporation (HVI). Interval time to development of PAVMs was 42.3 months (16-121). Four of the 12 patients were left with antegrade pulmonary blood flow (PBF) and three (75%) remain without PAVMs. Median follow-up was 10 years (1.5-22) with 11 of 12 (91.67%) survival for the cohort. Conclusions The KP can be done at a younger age than previously reported with adequate early and late results. Most patients will go on to develop PAVMs and require HVI but leaving patients with some antegrade PBF is likely protective but will need further investigation to show definitive benefit.
Optimizing the post-CAR T monitoring period in recipients of axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel
Authors: Ahmed Nausheen , Wesson William , Lutfi Forat , Porter David L. , Bachanova Veronika , Nastoupil Loretta J. , Perales Miguel-Angel , Maziarz Richard T. , Brower Jamie , Shah Gunjan L. , Chen Andy I. , Oluwole Olalekan O. , Schuster Stephen J. , Bishop Michael R. , McGuirk Joseph P. , Riedell Peter A. 
Published: July 2024

Abstract
CD19–directed chimeric antigen receptor T-cell (CAR T) therapies, including axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel), have transformed the treatment landscape for B-cell non-Hodgkin lymphoma, showcasing significant efficacy but also highlighting toxicity risks such as cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS). The US Food and Drug Administration has mandated patients remain close to the treatment center for 4 weeks as part of a Risk Evaluation and Mitigation Strategy to monitor and manage these toxicities, which, although cautious, may add to cost of care, be burdensome for patients and their families, and present challenges related to patient access and socioeconomic disparities. This retrospective study across 9 centers involving 475 patients infused with axi-cel, tisa-cel, and liso-cel from 2018 to 2023 aimed to assess CRS and ICANS onset and duration, as well as causes of nonrelapse mortality (NRM) in real-world CAR T recipients. Although differences were noted in the incidence and duration of CRS and ICANS between CAR T products, new-onset CRS and ICANS are exceedingly rare after 2 weeks after infusion (0% and 0.7% of patients, respectively). No new cases of CRS occurred after 2 weeks and a single case of new-onset ICANS occurred in the third week after infusion. NRM is driven by ICANS in the early follow-up period (1.1% until day 28) and then by infection through 3 months after infusion (1.2%). This study provides valuable insights into optimizing CAR T therapy monitoring, and our findings may provide a framework to reduce physical and financial constraints for patients.
Vibration Reduction by a Partitioned Dynamic Vibration Absorber with Acoustic Black Hole Features
Authors: Zhao Xiaoning , Wang Chaoyan , Ji Hongli , Qiu Jinhao , Cheng Li 
Published: July 2024

AbstractVibration quality is a vital indicator for assessing the progress of modern equipment. The dynamic vibration absorber (DVA) based on the acoustic black hole (ABH) feature is a new passive control method that manipulates waves. It offers efficient energy focalization and broad-spectrum vibration suppression, making it highly promising for applications in large equipment such as aircraft, trains, and ships. Despite previous advancements in ABH-DVA development, certain challenges remain, particularly in ensuring effective coupling with host structures during control. To address these issues, this study proposes a partitioned ABH-featured dynamic vibration absorber (PABH-DVA) with partitions in the radial direction of the disc. By employing a plate as the host structure, simulations and experiments were conducted, demonstrating that the PABH-DVA outperforms the original symmetric ABH-DVA in terms of damping performance. The study also calculated and compared the coupling coefficients of the two ABH-DVAs to uncover the mechanism behind the enhanced damping. Simulation results revealed that the PABH-DVA exhibits more coupled modes, occasionally with lower coupling coefficients than the symmetric ABH-DVA. The influence of frequency ratio and modal mass was further analyzed to explain the reasons behind the PABH-DVA's superior damping performance. Additionally, the study discussed the impact of the number of slits and their orientation. This research further explains the coupling mechanism between the ABH-DVA and the controlled structure, and provides new ideas for the further application of ABH in engineering.
Path-Dependent Progressive Failure Analysis for 3D-Printed Continuous Carbon Fibre Reinforced Composites
Authors: Chen Yuan , Ye Lin 
Published: July 2024

AbstractIn order to predict the damage behaviours of 3D-printed continuous carbon fibre (CCF) reinforced composites, when additional short carbon fibre (SCF) composite components are employed for continuous printing or special functionality, a novel path-dependent progressive failure (PDPF) numerical approach is developed. First, a progressive failure model using Hashin failure criteria with continuum damage mechanics to account for the damage initiation and evaluation of 3D-printed CCF reinforced polyamide (PA) composites is developed, based on actual fibre placement trajectories with physical measurements of 3D-printed CCF/PA constituents. Meanwhile, an elastic-plastic model is employed to predict the plastic damage behaviours of SCF/PA parts. Then, the accuracy of the PDPF model was validated so as to study 3D-printed CCF/PA composites with either negative Poisson’s ratio or high stiffness. The results demonstrate that the proposed PDPF model can achieve higher prediction accuracies in mechanical properties of these 3D-printed CCF/PA composites. Mechanism analyses show that the stress distribution is generally aggregated in the CCF areas along the fibre placement paths, and the shear damage and matrix tensile/compressive damage are the key damage modes. This study provides a new approach with valuable information for characterising complex 3D-printed continuous fibre-matrix composites with variable mechanical properties and multiple constituents.
The effect of P2X7 antagonism on subcortical spread of optogenetically-triggered cortical spreading depression and neuroinflammation
Authors: Uzay Burak , Donmez-Demir Buket , Ozcan Sinem Yilmaz , Kocak Emine Eren , Yemisci Muge , Ozdemir Yasemin Gursoy , Dalkara Turgay , Karatas Hulya 
Published: July 2024

AbstractMigraine is a neurological disorder characterized by episodes of severe headache. Cortical spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in opening of pannexin 1 megachannels that release ATP and triggers parenchymal neuroinflammatory signaling cascade in the cortex. Migraine symptoms suggesting subcortical dysfunction bring subcortical spread of CSD under the light. Here, we investigated the role of purinergic P2X7 receptors on the subcortical spread of CSD and its consequent neuroinflammation using a potent and selective P2X7R antagonist, JNJ-47965567. P2X7R antagonism had no effect on the CSD threshold and characteristics but increased the latency to hypothalamic voltage deflection following CSD suggesting that ATP acts as a mediator in the subcortical spread. P2X7R antagonism also prevented cortical and subcortical neuronal activation following CSD, revealed by bilateral decrease in c-fos positive neuron count, and halted CSD-induced neuroinflammation revealed by decreased neuronal HMGB1 release and decreased nuclear translocation of NF-kappa B-p65 in astrocytes. In conclusion, our data suggest that P2X7R plays a role in CSD-induced neuroinflammation, subcortical spread of CSD and CSD-induced neuronal activation hence can be a potential target.
Proteomic profile and predictive markers of outcome in patients with subarachnoid hemorrhage
Authors: Lolansen Sara Diana , Rostgaard Nina , Olsen Markus Harboe , Ottenheijm Maud Eline , Drici Lylia , Capion Tenna , Nørager Nicolas Hernandez , MacAulay Nanna , Juhler Marianne 
Published: July 2024

Abstract
Background
The molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) following subarachnoid hemorrhage (SAH) remain incompletely understood. Consequently, treatment strategies tailored towards the individual patient remain limited. This study aimed to identify proteomic cerebrospinal fluid (CSF) biomarkers capable of predicting shunt dependency and functional outcome in patients with SAH in order to improve informed clinical decision making.

Methods
Ventricular CSF samples were collected twice from 23 patients with SAH who required external ventricular drain (EVD) insertion (12 patients with successful EVD weaning, 11 patients in need of permanent CSF shunting due to development of PHH). The paired CSF samples were collected acutely after ictus and later upon EVD removal. Cisternal CSF samples were collected from 10 healthy control subjects undergoing vascular clipping of an unruptured aneurysm. All CSF samples were subjected to mass spectrometry-based proteomics analysis. Proteomic biomarkers were quantified using area under the curve (AUC) estimates from a receiver operating curve (ROC).

Results
CSF from patients with SAH displayed a distinct proteomic profile in comparison to that of healthy control subjects. The CSF collected acutely after ictus from patients with SAH was moreover distinct from that collected weeks later but appeared similar in the weaned and shunted patient groups. Sixteen unique proteins were identified as potential predictors of shunt dependency, while three proteins were identified as potential predictors of functional outcome assessed six months after ictus with the modified Rankin Scale.

Conclusions
We here identified several potential proteomic biomarkers in CSF from patients with SAH capable of predicting (i) shunt dependency and thus development of PHH and (ii) the functional outcome assessed six months after ictus. These proteomic biomarkers may have the potential to aid clinical decision making by predicting shunt dependency and functional outcome following SAH.
Urolithiasis unveiled: pathophysiology, stone dynamics, types, and inhibitory mechanisms: a review
Authors: Allam Essmat A. H. 
Published: July 2024

AbstractUrolithiasis is a multifaceted and common urological disorder characterized by the development of renal calculi. Calcium oxalate stones are the most prevalent type of calculi, forming when calcium and oxalate combine to produce crystalline structures in the urine. The incidence rates of urolithiasis exhibit geographical variations, which are determined by factors such as geographic location, age, sex, dietary habits, and genetics. The increasing trend of urolithiasis has emerged as a noteworthy public health issue, potentially attributed to shifts in dietary and lifestyle habits. In response to this challenge, various inhibitors of calcium oxalate crystal formation, including small molecules, peptides, and proteins, have been developed. Moreover, substances such as citrate, magnesium, inter-alpha-trypsin inhibitors, phytate, potassium, and pyrophosphates show promise in preventing kidney stones. A comprehensive metabolic assessment is crucial, customized for each patient, to effectively manage and avoid the recurrence of urolithiasis. Although specific pharmacological treatments for urolithiasis are currently unavailable, some drugs can reduce pain. Some drugs, including calcium channel blockers like nifedipine, phosphodiesterase-5 inhibitors like tadalafil, and alpha-blockers like tamsulosin, are thought to lower ureteral contractions by making the ureteral smooth muscle relax. In acute and severe pain cases, intravenous administration of narcotic analgesics and anti-inflammatory agents may be employed in emergency medical settings. To enhance therapeutic approaches, it is essential to gain more knowledge about the pathophysiology of renal calculi. The development of inhibitors targeting calcium oxalate crystal formation offers a promising avenue for urolithiasis prophylaxis. Identifying and investigating potential inhibitors lays the framework for the creation of more effective and targeted therapeutic options.Graphical Abstract