bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demandas del campo de la salud mental percibidas por psicólogos que trabajan en espacios de Orientación y Tutoría, en escuelas secundarias de Paraná Campaña
Authors: Siebenhar Martin 
Published: June 2024

La presente investigación se planteó en el marco de la Maestría en Salud Mental de la Facultad de Trabajo Social de la Universidad Nacional de Entre Ríos (FTS-UNER). Pretendió abordar una temática inserta en dos campos disciplinares complementarios: el de la salud, y más específicamente el de la salud mental y educación. El objetivo central persiguió conocer las demandas del campo de la salud mental que perciben los psicólogos que ocupan los espacios de orientación y tutoría en escuelas secundarias de Paraná Campaña.
Para la pesquisa se adoptó una lógica de generación conceptual, para ello se tomó como técnica de obtención de la información la entrevista semi-estructurada en profundidad a informantes clave. En lo que respecta al procesamiento de la información, se utilizó el método comparativo constante.
Los resultados obtenidos mostraron que las demandas percibidas por los psicólogos tutores cuentan con una diversidad significativa de situaciones, las cuales son visibilizadas por diferentes actores institucionales como estudiantes, docentes, preceptores, directivos e incluso los adultos que están a cargo del cuidado o crianza de los jóvenes. Se destaca que este espacio es de construcción artesanal por parte de quien desarrolla la función tutorial y que los abordajes de las demandas tienen un carácter singular, situacional y territorial, como condición para que el trabajo adquiera una impronta acorde a la complejidad de las intervenciones. Esto ha permitido resignificar la orientación y tutoría como un espacio de articulación entre lo educativo/pedagógico y la salud mental.
Dolores Rondón en el concierto de las leyendas y tradiciones funerarias.
Authors: Santana Sarduy Gricell Aurora , Jane Gavaldá Martha , Velastegui López Luis Efraín 
Published: June 2024

Los cementerios decimonónicos forman parte del imaginario de la fundación de las primeras siete villas en la Isla de Cuba, los que se han dado en llamar Cementerios Patrimoniales, es cada vez más el núcleo del turismo de cementerios. El texto que se presenta, aborda el patrimonio funerario en relación a las leyendas y tradiciones que en estos sitios se entretejen. Señala la posible relación incómoda entre el turismo de cementerios y patrimonio funerario, en parte debido a la falta de voluntad de asociar directamente las visitas a los cementerios con la muerte. Un turismo de cementerios mal planteado puede socavar el patrimonio tangible e intangible de los cementerios. Muchos cementerios siguen en uso y, por lo tanto, deben considerase como ‘patrimonio vivo’, y museos al aire libre. Por lo que se entiende que los sistemas de interpretación deben comunicar los diversos aspectos de la mortalidad, como elemento del desarrollo sociocultural de una comunidad. Poner de relieve las dinámicas de leyendas y tradiciones funerarias en un marco narrativo poco explorado pero necesario ponerlo en valor. Resguardando valores éticos toda vez que, en el caso de Cuba, muchos de nuestros primeros cementerios reciben los restos humanos de sus ciudadanos. Este texto propone una mirada desde las leyendas funerarias que se entretejen en el imaginario popular y que resultan un atractivo para el Turismo.
Alat Penyortir Telur Bebek Otomatis Berdasarkan Bobot
Authors: Styorini Wiwin - , Nisrina Nurul Anisah  , Harpawi Noptin , M.Suhairi  
Published: June 2024

Pada umumnya penyortiran telur di UMKM produsen telur bebek dilakukan secara manual oleh manusia, sehingga membutuhkan tenaga kerja dan waktu yang lebih lama serta kurang efisien. Selain itu, kesalahan manusia dalam menentukan bobot telur juga dapat mempengaruhi akurasi dalam proses penyortiran. Dalam penelitian ini dibuat sebuah alat pernyortir telur bebek otomatis berdasarkan bobot. Dengan alat ini diharapkan dapat memberikan solusi atas permasalahan yang ada. Alat yang telah dibuat menggunakan konveyor untuk membawa telur secara otomatis ke sensor load cell untuk ditimbang, dan motor servo sebagai pemilah telur berdasarkan bobot yang telah ditimbang oleh sensor load cell. Hasil telur yang disortir terbagi menjadi 3 klasifikasi bobot yaitu ringan, sedang, dan berat. Data bobot-bobot telur yang telah terukur akan masuk kedalam microsoft excel dengan bantuan software PLX-DAQ. Alat penyortir telur bebek otomatis ini membutuhkan waktu 8,73 detik per butir dengan keakurasian bobot 98,36%.
Kemerdekaan Dosen dalam Beban Kerja dan Karir: Konsep Tata Kelola Institusi dan Reformasi Administrasi di Perguruan Tinggi
Authors: Azfirmawarman Dony , Adnan M. Fachri , Khaidir Afriva 
Published: June 2024

Perubahan dalam sistem evaluasi kinerja dosen, seperti Bobot Kinerja Dosen (BKD) yang disesuaikan dengan Merdeka Belajar Kampus Merdeka (MBKM), serta prosedur akumulasi digital, bertujuan untuk mengurangi beban administrasi dosen. Namun, masih terdapat hambatan dalam menjaga proses mencerdaskan kehidupan bangsa dan produktivitas dosen dalam membuat karya akademis. Artikel ini membahas tentang Kemerdekaan Dosen dalam Beban Kerja dan Karir di Perguruan Tinggi, fokus pada konsep tata kelola institusi dan reformasi administrasi. Dalam melakukan penelitian ini, peneliti menggunakan kajian pustaka/ literatur sebagai metode penelitiannya dimana informasi yang diperoleh berasal dari buku – buku terkait, surat kabar, majalah,serta publikasi dari lembaga–lembaga yang kompeten. Setelah data terkumpul, penulis melakukan analisa terhadap data yang ada, melakukan interprestasi dan terakhir menyimpulkan hasil dari kajian ini. Hasil penelitian ini memperlihatkan bahwa terdapat masalah struktural terkait pendanaan riset di Indonesia, dimana dana riset pemerintah masih tergolong kecil dibandingkan negara-negara tetangga. Perubahan kebijakan dalam beban kerja dosen, seperti BKD Baru yang bertujuan untuk meningkatkan bobot indikator dalam program Kampus Merdeka, serta mendukung pengembangan minat dan potensi dosen. Inovasi dalam tata kelola administrasi institusi diperlukan untuk memecahkan permasalahan yang ada, dengan memanfaatkan teknologi dan memperkenalkan prosedur baru.
Discovery and characterization of BRBV-sheep virus in nasal swabs from domestic sheep in China
Authors: Zhang Yufei , Li Yang , Qi Lemuge , Hang Tianyu , Wang Peng , Wang Yarong , Wu Caili , Wang Yongqin , Wang Xufen , Hou Lin , Ban Yaxing , Zhang Zhidan , Zhou Weiguang 
Published: June 2024

IntroductionThe escalating occurrence of infectious disease outbreaks in humans and animals necessitates innovative, effective, and integrated research to better comprehend their transmission and dynamics. Viral infection in livestock has led to profound economic losses globally. Pneumonia is the prevalent cause of death in sheep. However, very few studies exist regarding virus-related pathogens in sheep. Metagenomics sequencing technologies in livestock research hold significant potential to elucidate these contingencies and enhance our understanding.MethodsTherefore, this study aims to characterize respiratory viromes in paired nasal swabs from Inner Mongolian feedlot sheep in China using metaviromic sequencing. Through deep sequencing, de novo assembly, and similarity searches using translated protein sequences, several previously uncharacterized and known viruses were identified in this study.ResultsAmong these discoveries, a novel Bovine Rhinitis B Virus (BRBV) (BRBV-sheep) strain was serendipitously detected in the nasal swabs of domestic sheep (Ovis aries). To facilitate further molecular epidemiological studies, the entire genome of BRBV-sheep was also determined. Owing to the unique sequence characteristics and phylogenetic position of BRBV-sheep, genetically distinct lineages of BRBV in sheep may exist. A TaqMan-based qRT-PCR assay targeting the 3D polymerase gene was developed and used to screen 592 clinical sheep specimens. The results showed that 44.59% of the samples (264/592) were positive. These findings suggest that BRBV sheep are widespread among Inner Mongolian herds.ConclusionThis discovery marks the initial identification of BRBV in sheep within Inner Mongolia, China. These findings contribute to our understanding of the epidemiology and genetic evolution of BRBV. Recognizing the presence of BRBV in sheep informs strategies for disease management and surveillance and the potential development of targeted interventions to control its spread.
Effect of the degree of follicular diameter ≥18mm differentiation on the day of hCG administration to the outcome of controlled ovarian hyperstimulation (COH)
Authors: Xu Hongyi , Chen Qi , Tian Jiarong , Chen Xin , Zhang Xin , Li Xin , Wu Ying , Zhang Changjun , Zhang Ying 
Published: June 2024

ObjectiveTo explore the impact of the level of differentiation in a minimum of two follicles with a diameter of ≥18 mm on the outcome of controlled ovarian hyperstimulation on the day of human chorionic gonadotropin (hCG) administration.MethodsSingle-center data from January 2018 to December 2021 was retrospectively analyzed for 1,199 patients with fresh embryo transfer for assisted reproduction. The absolute value of the standard deviation of the follicle size of at least 2 follicles ≥18 mm in diameter in both ovaries on the day of hCG was taken as the degree of differentiation of the dominant follicle after ovulation induction, based on the standard deviation response to the degree of dispersion of the data. The degree of follicular differentiation was divided into 3 groups according to the size of the value, and the general clinical conditions, laboratory indexes, and clinical outcomes of the patients in the 3 groups were compared.ResultsAmong the three groups, the body mass index (BMI) of the ≤1s group was lower than that of the other two groups (P&lt; 0.05), while the follicle-stimulating hormone (FSH) and Anti-Mullerian hormone (AMH) were higher (P&lt; 0.05), and the implantation rate and clinical pregnancy rate were significantly higher than those of the other two groups (P&lt; 0.01). After multifactorial logistic regression to correct for confounding factors, with the ≤1s group as the reference, the implantation rate, hCG-positive rate, clinical pregnancy rate and live birth rate of embryo transfer in the ≥2S group were significantly lower (P&lt; 0.01). The results of curve fitting analysis showed that the live birth rate decreased gradually with the increase of the absolute standard deviation (P=0.0079).ConclusionDifferences in follicle diameters ≥18 mm on the day of hCG injection did not have an impact on embryo quality, but had an impact on pregnancy outcomes. The less the variation in follicle size, the more homogeneous the follicle development and the higher the likelihood of live births.
An in-hospital physiotherapy clinic improves symptoms and absenteeism among healthcare professionals with musculoskeletal conditions
Authors: Grewal S. , Vos V. , Theijse R. , Klautz R. , Grewal N. 
Published: June 2024

IntroductionThe incidence of work-related musculoskeletal disorders has been consistently high in the healthcare sectors, with significant impact on quality of life of affected individuals and costs to health services due to absenteeism. This study assesses the effectiveness of an in-hospital physiotherapy clinic “CollegaPoli” for healthcare professionals with musculoskeletal conditions. The primary objective was to evaluate the effectiveness of the “CollegaPoli” on reduction of musculoskeletal symptoms. Secondary, readiness to return to work was studied.MethodsA prospective observational study was conducted between October 2022 and June 2023. Healthcare professionals with musculoskeletal conditions resulting in sick leave were included. The effects of the “CollegaPoli” on reported symptoms and work absenteeism were evaluated.ResultsA total of 145 participants (84.1% female) were included in the study. Mainstream of participants reported musculoskeletal symptoms in the upper extremity (54.1%) and lower back (15.8%). Around 35% of the healthcare workers reported their symptoms to be present for 1–4 weeks, 25% since the past 7 days. The return-to-work program significantly reduced the musculoskeletal symptoms (p &lt; 0.001) and led to an 80.3% decrease in reported absenteeism among participants.ConclusionThis study supports the benefits of an in-hospital physiotherapy clinic among healthcare professionals with musculoskeletal disorders, improving symptoms and reducing absenteeism.
Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis
Authors: Zhou Jiejun , Zhang Youqian , Yang Tian , Zhang Kun , Li Anqi , Li Meng , Peng Xiaojing , Chen Mingwei 
Published: June 2024

BackgroundFormer research has emphasized a correlation between lung cancer (LC) and sepsis, but the causative link remains unclear.MethodThis study used univariate Mendelian Randomization (MR) to explore the causal relationship between LC, its subtypes, and sepsis. Linkage Disequilibrium Score (LDSC) regression was used to calculate genetic correlations. Multivariate MR was applied to investigate the role of seven confounding factors. The primary method utilized was inverse-variance-weighted (IVW), supplemented by sensitivity analyses to assess directionality, heterogeneity, and result robustness.ResultsLDSC analysis revealed a significant genetic correlation between LC and sepsis (genetic correlation = 0.325, p = 0.014). Following false discovery rate (FDR) correction, strong evidence suggested that genetically predicted LC (OR = 1.172, 95% CI 1.083–1.269, p = 8.29 × 10−5, Pfdr = 2.49 × 10−4), squamous cell lung carcinoma (OR = 1.098, 95% CI 1.021–1.181, p = 0.012, Pfdr = 0.012), and lung adenocarcinoma (OR = 1.098, 95% CI 1.024–1.178, p = 0.009, Pfdr = 0.012) are linked to an increased incidence of sepsis. Suggestive evidence was also found for small cell lung carcinoma (Wald ratio: OR = 1.156, 95% CI 1.047–1.277, p = 0.004) in relation to sepsis. The multivariate MR suggested that the partial impact of all LC subtypes on sepsis might be mediated through body mass index. Reverse analysis did not find a causal relationship (p &gt; 0.05 and Pfdr &gt; 0.05).ConclusionThe study suggests a causative link between LC and increased sepsis risk, underscoring the need for integrated sepsis management in LC patients.
Cellular immunity against cytomegalovirus and risk of infection after kidney transplantation
Authors: Blom Kjersti B. , Kro Grete B. , Midtvedt Karsten , Jenssen Trond G. , Reisæter Anna Varberg , Rollag Hallvor , Hartmann Anders , Sagedal Solbjørg , Sjaastad Ivar , Tylden Garth , Njølstad Gro , Nilsen Einar , Birkeland Jon A. , Åsberg Anders 
Published: June 2024

IntroductionCytomegalovirus (CMV) infection remains a challenge following kidney transplantation (KTx). Currently, CMV-IgG serostatus at transplantation is used to individualize CMV preventive strategies. We assessed the clinical utility of CMV-IGRA for predicting CMV infection following KTx.MethodsWe performed a nationwide prospective cohort study from August 2016 until December 2022. Data from all adult KTx recipients in Norway, n=1,546 (R+; n=1,157, D+/R-; n=260, D-/R-; 129), were included with a total of 3,556 CMV-IGRA analyses (1,375 at KTx, 1,188 at eight weeks, 993 one-year after KTx) and 35,782 CMV DNAemia analyses.ResultsIn R+ recipients CMV-IGRA status, measured at any of the time-points, could not identify any differential risk of later CMV infection. D+/R- recipients remaining CMV-IGRA negative 1-year after transplantation (regardless of positive CMV DNAemia and/or CMV IgG status at that time) had increased risk of developing later CMV infection compared to D+/R- recipients who had become CMV-IGRA positive (14% vs. 2%, p=0.01).ConclusionKnowledge of pre-transplant CMV-IGRA status did not provide additional information to CMV-IgG serostatus that could improve current post-transplant CMV treatment algorithms. However, D+/R- recipients with a persisting negative CMV-IGRA one-year after transplantation remained at increased risk of experiencing later CMV infection. Therefore we advocate post-transplant CMV-IGRA monitoring in these patients.
Detection of cytokines in cervicovaginal lavage in HIV-infected women and its association with high-risk human papillomavirus
Authors: Schindler Sandra , Netto Eduardo , Deminco Felice , Figueiredo Camila A. , de Andrade Candace Machado , Alves Amanda Rosa , Brites Carlos 
Published: June 2024

BackgroundWomen living with HIV/AIDS (WLHA) have an increased prevalence of high-risk HPV infection (HR-HPV) and cervical intraepithelial neoplasia (CIN) and a greater risk of cervical cancer despite access to a new generation of antiretroviral therapy. The aim of this study is to evaluate the concentrations of different cytokines involved in the local immune response in WLHA, which is fundamental for understanding the pathogenesis of HPV-related cancer in this population.MethodsIL-1β, IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, IP-10, GM-CSF, and MIP-1α were investigated in the cervicovaginal lavage (CVL) of 106 WLHA attending at Hospital Universitario Professor Edgard Santos in Salvador, Bahia, Brazil, during the period December 2019 to April 2023 by Luminex®. All participants were also tested for Chlamydia trachomatis and Neisseria gonorrhoeae and underwent colposcopy, Pap smear, and Nugent score. HIV plasma viral load (VL) and CD4 cell count were performed for all WLHA.ResultsIn this study, 22.6% (24/106) of WLHA were infected with HR-HPV. A higher proportion of patients with HR-HPV (66.7%) had detectable levels of IL-10 than those negative ones (40.2%, p = 0.02). More premenopausal women had either IL-6 (51.4%) or IP-10 (58.3%) than those in menopausal status (26.5% for IL-6 and 32.4% for IP-10, p = 0.013 and p = 0.011, respectively). Vaginosis was negatively associated with detection of IP-10 (24.2% vs. 61.4%, p &lt; 0.001) and INF-γ (39.4% vs. 68.6%, p = 0.005). A positive association was detected for IL-1β (66.7 vs. 37.1%, p = 0.005) and IL-10 (63.6% vs. 37.1%, p = 0.01). VL and CD4 were not associated with the studied cytokines.ConclusionWe demonstrated a positive association between IL-10 and HPV infection in CVL, suggesting the predominance of the Th2 response in HIV/HPV co-infected patients. However, further studies with longer follow-up will be needed to evaluate the association of IL-10 with HPV infection, CIN, and cervical cancer in WLHA.
Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice
Authors: Pan Allen L. , Audrain Mickael , Sakakibara Emmy , Joshi Rajeev , Zhu Xiaodong , Wang Qian , Wang Minghui , Beckmann Noam D. , Schadt Eric E. , Gandy Sam , Zhang Bin , Ehrlich Michelle E. , Salton Stephen R. 
Published: June 2024

IntroductionDual specificity protein phosphatase 6 (DUSP6) was recently identified as a key hub gene in a causal VGF gene network that regulates late-onset Alzheimer’s disease (AD). Importantly, decreased DUSP6 levels are correlated with an increased clinical dementia rating (CDR) in human subjects, and DUSP6 levels are additionally decreased in the 5xFAD amyloidopathy mouse model.MethodsTo investigate the role of DUSP6 in AD, we stereotactically injected AAV5-DUSP6 or AAV5-GFP (control) into the dorsal hippocampus (dHc) of both female and male 5xFAD or wild type mice, to induce overexpression of DUSP6 or GFP.ResultsBarnes maze testing indicated that DUSP6 overexpression in the dHc of 5xFAD mice improved memory deficits and was associated with reduced amyloid plaque load, Aß1–40 and Aß1–42 levels, and amyloid precursor protein processing enzyme BACE1, in male but not in female mice. Microglial activation, which was increased in 5xFAD mice, was significantly reduced by dHc DUSP6 overexpression in both males and females, as was the number of “microglial clusters,” which correlated with reduced amyloid plaque size. Transcriptomic profiling of female 5xFAD hippocampus revealed upregulation of inflammatory and extracellular signal-regulated kinase pathways, while dHc DUSP6 overexpression in female 5xFAD mice downregulated a subset of genes in these pathways. Gene ontology analysis of DEGs (p &lt; 0.05) identified a greater number of synaptic pathways that were regulated by DUSP6 overexpression in male compared to female 5xFAD.DiscussionIn summary, DUSP6 overexpression in dHc reduced amyloid deposition and memory deficits in male but not female 5xFAD mice, whereas reduced neuroinflammation and microglial activation were observed in both males and females, suggesting that DUSP6-induced reduction of microglial activation did not contribute to sex-dependent improvement in memory deficits. The sex-dependent regulation of synaptic pathways by DUSP6 overexpression, however, correlated with the improvement of spatial memory deficits in male but not female 5xFAD.
Non-coding RNAs involved in the molecular pathology of Alzheimer’s disease: a systematic review
Authors: Canoy Reynand Jay , Sy Jenica Clarisse , Deguit Christian Deo , Castro Caitlin Bridgette , Dimaapi Lyoneil James , Panlaqui Beatrice Gabrielle , Perian Wenzel , Yu Justine , Velasco John Mark , Sevilleja Jesus Emmanuel , Gibson Anna 
Published: June 2024

Alzheimer’s disease (AD) is the leading cause of dementia globally, having a pathophysiology that is complex and multifactorial. Recent findings highlight the significant role of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and piwi-interacting RNAs (piRNAs) in the molecular mechanisms underlying AD. These ncRNAs are involved in critical biological processes such as cell proliferation, apoptosis, oxidative stress, amyloid-beta aggregation, tau phosphorylation, neuroinflammation, and autophagy, which are pivotal in AD development and progression. This systematic review aims to consolidate current scientific knowledge on the role of ncRNAs in AD, making it the first to encompass the four types of ncRNAs associated with the disease. Our comprehensive search and analysis reveal that ncRNAs not only play crucial roles in the pathogenesis of AD but also hold potential as biomarkers for its early detection and as novel therapeutic targets. Specifically, the findings underscore the significance of miRNAs in regulating genes involved in key AD pathways such as activin receptor signaling pathway, actomyosin contractile ring organization, and advanced glycation endproducts-receptor advanced glycation endproducts (AGE-RAGE) signaling pathway. This review also highlights the potential of ncRNAs in unveiling novel diagnostic and therapeutic strategies, emphasizing the need for further research to validate their clinical utility. Our systematic exploration provides a foundation for future bioinformatic analyses and the development of ncRNA-based precision medicine approaches for AD, offering new insights into the disease’s molecular pathology and paving the way for innovative treatment strategies.Systematic review registrationPROSPERO, https://www.crd.york.ac.uk/prospero/, CRD42022355307.