bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between Congenital Heart Defects and maternal copper and zinc concentrations
Authors: Hu Hui , Liu Zhen , Li Jun , Li Shengli , Tian Xiaoxian , Lin Yuan , Chen Xinlin , Yang Jiaxiang , Deng Ying , Li Nana , Wang Yanping , Yuan Ping , Li Xiaohong , Zhu Jun 
Published: August 2014

BackgroundThe aim of this study was to investigate the correlation between maternal concentrations of copper and zinc and the risk of having an infant with a congenital heart defect (CHD).MethodsA multi‐center hospital‐based case‐control study was conducted in China. A total of 212 cases and 212 controls were recruited from pregnant women who received prenatal examinations in four tertiary hospitals accredited to perform prenatal diagnosis in the cities of Shenzhen, Zhenzhou, Fuzhou and Wuhan between February 2010 and November 2011. Correlation between CHDs and maternal copper and zinc concentrations was estimated by a 1:1 conditional logistic regression. Also the interaction between copper and zinc was analyzed.ResultsCompared with the controls, mothers with hair copper concentrations of 17.77 μg/g or more were more likely to have a child with a CHD than those with a lower concentration. The adjusted odds ratio was 5.70 (95% confidence interval, 2.58–12.61) for CHDs and 6.32 (95% confidence interval, 2.11–18.92) for conotruncal defects. Zinc concentrations were not significantly different in the case and control groups. The results suggest that mothers whose zinc content was 104.60 μg/g or less did not have a significantly higher risk of having a child with a CHD. No interaction between maternal copper and zinc concentrations was observed in the multiplicative or additive model.ConclusionWomen with excessive copper concentrations have a significantly increased risk of having offspring with a CHD. A low maternal zinc status might have a correlation with CHDs, and an interaction between copper and zinc might exists, but an epidemiological study with a larger sample size is needed to confirm this finding. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. Birth Defects Research (Part A) 100:965–972, 2014. © 2014 Wiley Periodicals, Inc.
Meta-analysis and meta-regression analysis of biomarkers for abdominal aortic aneurysm
Authors: Stather P W , Sidloff D A , Dattani N , Gokani V J , Choke E , Sayers R D , Bown M J 
Published: August 2014

Abstract

Background
Many studies have investigated the systemic and local expression of biomarkers in patients with abdominal aortic aneurysm (AAA). The natural history of AAA varies between patients, and predictors of the presence and diameter of AAA have not been determined consistently. The aim of this study was to perform a systematic review, meta-analysis and meta-regression of studies comparing biomarkers in patients with and without AAA, with the aim of summarizing the association of identified markers with both AAA presence and size.

Methods and results
Literature review identified 106 studies suitable for inclusion. Meta-analysis demonstrated a significant difference between matrix metalloproteinase (MMP) 9, tissue inhibitor of matrix metalloproteinase 1, interleukin (IL) 6, C-reactive protein (CRP), α1-antitrypsin, triglycerides, lipoprotein(a), apolipoprotein A and high-density lipoprotein in patients with and without AAA. Although meta-analysis was not possible for MMP-2 in aortic tissue, tumour necrosis factor α, osteoprotegerin, osteopontin, interferon γ, intercellular cell adhesion molecule 1 and vascular cell adhesion molecule 1, systematic review suggested an increase in these biomarkers in patients with AAA. Meta-regression analysis identified a significant positive linear correlation between aortic diameter and CRP level.

Conclusion
A wide variety of biomarkers are dysregulated in patients with AAA, but their clinical value is yet to be established. Future research should focus on the most relevant biomarkers of AAA, and how they could be used clinically.
LC‐MS/MS analysis of Gegen Qinlian Decoction and its pharmacokinetics after oral administration to rats
Authors: Zhang Yifan , Yuan Jin , Zhang Yizhu , Chen Ye , Cao Jiaoxian , An Rui , Wang Xinhong 
Published: August 2014

AbstractA liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method was developed and validated for the simultaneous determination of 12 constituents of Gegen Qinlian Decoction (GQD), namely puerarin, daidzein, baicalin, wogonoside, wogonin, liquiritin, liquiritigenin, berberine, jatrorrhizine, palmatine, coptisine and glycyrrhetic acid, in rat plasma. The plasma samples were spiked with the internal standard (IS) carbamazepine acidified with HCl and extracted by liquid–liquid extraction with ethyl acetate. Chromatographic separation was achieved on a Shiseido Capcell PAK C18 column utilizing a gradient elution profile and a mobile phase consisting of (A) 0.1% formic acid in water and (B) acetonitrile. Detection was performed in the multiple reaction monitoring mode using electrospray ionization in the positive ion mode at a flow rate of 0.3 mL/min and a run time of 8 min. All of the calibration curves gave good linearity (r > 0.9930) over the concentration range from 0.6–360 to 16.2–9720 ng/mL for all components. The intra‐ and inter‐day precisions were <15.0% in terms of the relative standard deviation, and the accuracies were within ±13.7% in terms of the relative error. The method was successfully applied to investigate the pharmacokinetics of the major active compounds of Gegen Qinlian Decoction after its oral administration to rats. Copyright © 2014 John Wiley & Sons, Ltd.
An Abnormal N‐Heterocyclic Carbene–Carbon Dioxide Adduct from Imidazolium Acetate Ionic Liquids: The Importance of Basicity
Authors: Kelemen Zsolt , Péter‐Szabó Barbara , Székely Edit , Hollóczki Oldamur , Firaha Dzmitry S. , Kirchner Barbara , Nagy József , Nyulászi László 
Published: August 2014

AbstractIn the reaction of 1‐ethyl‐3‐methylimidazolium acetate [C2C1Im][OAc] ionic liquid with carbon dioxide at 125 °C and 10 MPa, not only the known N‐heterocyclic carbene (NHC)–CO2 adduct I, but also isomeric aNHC‐CO2 adducts II and III were obtained. The abnormal NHC‐CO2 adducts are stabilized by the presence of the polarizing basic acetate anion, according to static DFT calculations and ab initio molecular dynamics studies. A further possible reaction pathway is facilitated by the high basicity of the system, deprotonating the initially formed NHC‐CO2 adduct I, which can then be converted in the presence of the excess of CO2 to the more stable 2‐deprotonated anionic abnormal NHC–CO2 adduct via the anionic imidazolium‐2,4‐dicarboxylate according to DFT calculations on model compounds. This suggests a generalizable pathway to abnormal NHC complex formation.
AgONO‐Assisted Direct CH Arylation of Heteroarenes with Anilines
Authors: Gowrisankar Saravanan , Seayad Jayasree 
Published: August 2014

AbstractA novel copper‐catalyzed CH arylation of heteroarenes with anilines by an in situ diazonium reaction is established by using silver nitrite (AgONO) as an unconventional nitrosating reagent under acid‐free conditions. It provides a complementary approach for the CH arylation of electron‐rich heteroarenes with aromatic amines affording a variety of heterobiaryls in moderate to good yields.
Optimizing the computation of a parallel 3D finite difference algorithm for graphics processing units
Authors: Porter‐Sobieraj J. , Cygert S. , Kikoła D. , Sikorski J. , Słodkowski M. 
Published: August 2014

SummaryThis paper explores the possibilities of using a graphics processing unit for complex 3D finite difference computation via MUSTA‐FORCE and WENO algorithms. We propose a novel algorithm based on the new properties of CUDA surface memory optimized for 2D spatial locality and compare it with 3D stencil computations carried out via shared memory, which is currently considered to be the best approach. A case study was performed for the extensive generation of a time series of 3D grids of arbitrary size used in the computation of collisions between heavy nuclei in terms of relativistic hydrodynamics. It proved that implementation based on surface memory is as much as 23% faster than an equivalent implementation using shared memory. Copyright © 2014 John Wiley & Sons, Ltd.
Tetranuclear Copper(II) Complexes with Macrocyclic and Open‐Chain Disiloxane Ligands as Catalyst Precursors for Hydrocarboxylation and Oxidation of Alkanes and 1‐Phenylethanol
Authors: Zaltariov Mirela‐Fernanda , Alexandru Mihaela , Cazacu Maria , Shova Sergiu , Novitchi Ghenadie , Train Cyrille , Dobrov Anatolie , Kirillova Marina V. , Alegria Elisabete C. B. A. , Pombeiro Armando J. L. , Arion Vladimir B. 
Published: August 2014

AbstractTwo new tetranuclear copper(II) complexes [Cu4(μ4‐O)(L1)Cl4] (1) and [Cu4(μ4‐O)(L2)2Cl4] (2), where H2L1 is a macrocyclic ligand resulting from [2+2] condensation of 2,6‐diformyl‐4‐methylphenol (DFF) and 1,3‐bis(aminopropyl)tetramethyldisiloxane, and HL2 is a 1:2 condensation product of DFF with trimethylsilyl p‐aminobenzoate, have been prepared. The structures of the products were established by X‐ray diffraction. The complexes have been characterised by FTIR, UV/Vis spectroscopy, ESI mass‐spectrometry and magnetic susceptibility measurements. The latter revealed that the tetranuclear complexes can be described as two ferromagnetically coupled dinuclear units, in which the two copper(II) ions interact antiferromagnetically. The compounds act as homogeneous catalyst precursors for a number of single‐pot reactions, including (i) hydrocarboxylation, with CO, H2O and K2S2O8, of a variety of linear and cyclic(n = 5–8) alkanes into the corresponding Cn+1 carboxylic acids, (ii) peroxidative oxidation of cyclohexane, and (iii) solvent‐free microwave‐assisted oxidation of 1‐phenylethanol.
Reduction of olive fruit fly damage by early harvesting and impact on oil quality parameters
Authors: Rojnić Ivana Dminić , Bažok Renata , Barčić Jasminka Igrc 
Published: August 2014

Olive fly population was monitored weekly on two olive cultivars (Buža and Istarska bjelica), from June until mid October, in Rovinj and Livade (Istria, Croatia). The number of eggs, larvae, and pupae was established and the total and active infestation was calculated. The fruit infestations for early and for late harvesting were obtained based on the calculated regression equation. For the prediction of the changes in the oil quality parameters linear regression slopes, obtained by Koprivnjak et al., were used. We established a strong positive correlation between DD accumulation and cumulative capture of flies, as well as with the total and active fruit infestations. According to obtained results it can be stated that I. bjelica is less sensitive to decrease in total phenols amount, to increase in free fatty acids mass ratio and to increase in peroxide values comparing to Buža. Moreover, the differences in investigated parameters between earlier and late harvesting dates in I. bjelica are lower due to lower infestation predicted for both harvesting dates and due to lower sensitivity to the changes in quality parameters. Therefore, early harvesting date as a model for preventing fruit damage and as a model for preventing negative change in oil quality parameters is a valid tool. However, the effectiveness of this model could also depend on the characteristics of olive cultivar.Practical applications: Understanding the factors that affect the olive fly attack is the basis of scientific and practical interest in the production of olives and olive oil. Research of monitoring methods allows reliable forecasting and determining protection measures. Knowledge about this topic could contribute to the reduction of insecticides use and to the improvement of quality and food safety concept in olive oil production.Damaged olive fruits are proved to directly affect the quantitative and qualitative properties of olive oils. The most important fruit damage is caused by the olive fly (Bactrocera oleae Gmelin).
Argan oil, the 35‐years‐of‐research product
Authors: Charrouf Zoubida , Guillaume Dominique 
Published: August 2014

Argan oil is nowadays a major and internationally well‐established actor on the edible‐oil as well as cosmetic‐oil markets. Nevertheless, argan oil fame is quite recent. Indeed, due to important quality matters, argan oil had remained ignored for years. During all this time, argan oil's numerous pharmacological properties have provided benefit only to the population of the Essaouira and Sous Massa Draa regions, the part of the world where argan oil is exclusively produced. Argan oil's world‐wide success is principally the result of a vast multidisciplinary program initiated by the government of Morocco almost 35 years ago. This program, which began by the chemical characterization of argan oil and argan metabolites, has subsequently allowed the establishment of an official, and internationally recognized, argan oil quality norm, together with good preparation pratice guidelines. Because of this norm and these stringent guidelines argan oil has got the trust of customers. This has led to the triggering of its international recognition. Concomittantly, private, governmental and non‐governmental organizations have taken great care to ensure that a large part of argan‐oil derived wealth was redistributed to the Sous Massa Draa population, principally through the building of woman‐managed argan oil preparation cooperatives. This paper relates the major steps of the argan oil saga.Going from the argan tree to high quality argan oil in 35 years.
Comparison of POD reduced order strategies for the nonlinear 2D shallow water equations
Authors: Ştefănescu Răzvan , Sandu Adrian , Navon Ionel M. 
Published: August 2014

SUMMARYThis paper introduces tensorial calculus techniques in the framework of POD to reduce the computational complexity of the reduced nonlinear terms. The resulting method, named tensorial POD, can be applied to polynomial nonlinearities of any degree p. Such nonlinear terms have an online complexity of , where k is the dimension of POD basis and therefore is independent of full space dimension. However, it is efficient only for quadratic nonlinear terms because for higher nonlinearities, POD model proves to be less time consuming once the POD basis dimension k is increased. Numerical experiments are carried out with a two‐dimensional SWE test problem to compare the performance of tensorial POD, POD, and POD/discrete empirical interpolation method (DEIM). Numerical results show that tensorial POD decreases by 76× the computational cost of the online stage of POD model for configurations using more than 300,000 model variables. The tensorial POD SWE model was only 2 to 8× slower than the POD/DEIM SWE model but the implementation effort is considerably increased. Tensorial calculus was again employed to construct a new algorithm allowing POD/DEIM SWE model to compute its offline stage faster than POD and tensorial POD approaches. Copyright © 2014 John Wiley & Sons, Ltd.
Effects of Potential on Corrosion Behavior of Uncoated SS316L Bipolar Plate in Simulated PEM Fuel Cell Cathode Environment
Authors: Yang Y. , Ning X. , Tang H. , Guo L. , Liu H. 
Published: August 2014

AbstractThe effect of potential on the corrosion behavior of uncoated stainless steel SS316L as bipolar plate material in proton exchange membrane (PEM) fuel cell cathode environment is studied. Electrochemical methods, X‐ray photoelectron spectroscopy, scanning electron microscope are employed to characterize the corrosion behavior of SS316L at different polarization potentials in PEM fuel cell cathode environment. The results show that the corrosion current density of SS316L increases with the increase of polarization potential significantly. When the potential is higher than 0.7 V versus SCE, severe corrosion occurs on SS316L. The work also shed light on the corrosion mechanisms of SS316L at different potential in the PEM fuel cell cathode environment.
Effect of Ru/CGO versus Ni/CGO Co‐Infiltration on the Performance and Stability of STN‐Based SOFCs
Authors: Ramos T. , Veltzé S. , Sudireddy B. R. , Jørgensen P. S. , Theil Kuhn L. , Holtappels P. 
Published: August 2014

AbstractElectrolyte supported cells (ESC), with Sc2O3‐stabilized ZrO2 (ScSZ) electrolytes, Gd‐doped ceria (CGO) or M/CGO (M = Ni, Ru) infiltrated Sr0.94Ti0.9Nb0.1O3 (STN94) anodes and LSM/YSZ cathodes, were evaluated for their initial performance and long‐term stability. Power density for the Ru/CGO infiltrated cell reached ∼0.7 W cm–2 at 850 °C, 4% H2O/H2, whereas the Ni/CGO infiltrated cell reached ∼0.3 W cm–2, with the current morphologies and loadings. Operation at 0.125 A cm–2, 850 °C, feeding 50% H2O/H2 to the anode and air to the cathode, for a period >300 h, showed superior stability for the Ru/CGO infiltrated cell, with ∼0.04 mV h–1 degradation rate, when compared to the Ni/CGO infiltrated cell (∼0.5 mV h–1). For the Ni/CGO case, the observed degradation has been tentatively linked to initial changes in the electrochemical active area and long‐term detrimental interactions between components.
MLL/KMT2A translocations in diffuse large B‐cell lymphomas
Authors: Gindin Tatyana , Murty Vundavalli , Alobeid Bachir , Bhagat Govind 
Published: August 2014

AbstractTranslocations of the histone‐lysine N‐methyltransferase 2A (KMT2A) gene, formerly known as myeloid lymphoid leukemia/mixed‐lineage leukemia gene, are commonly associated with high‐risk de novo or therapy‐associated B‐cell and T‐cell lymphoblastic leukemias and myeloid neoplasms. Rare B‐cell non‐Hodgkin lymphomas harboring KMT2A translocations have been reported, but information regarding the clinical behavior of such cases is limited. Here, we describe two extranodal diffuse large B‐cell lymphomas (DLBCLs): a primary thyroid DLBCL and a large cell transformation of a splenic marginal zone lymphoma, which displayed complex karyotypes and translocations involving chromosome 11q23 targeting the KMT2A gene. The pathological and clinical characteristics of these cases are discussed in the context of previously reported lymphomas associated with different types of KMT2A genetic aberrations. In contrast to the poor clinical outcomes of patients with acute leukemias and myeloid neoplasms associated with KMT2A translocations, patients with B‐cell non‐Hodgkin lymphomas, exhibiting similar translocations, appear to respond well to immunochemotherapy. Our findings add to the growing list of histone methyltransferase genes deregulated in DLBCL and highlight the diversity of mechanisms, altering the function of epigenetic modifier genes in lymphomas.
CO2 Reduction to Substitute Natural Gas: Toward a Global Low Carbon Energy System
Authors: Walspurger Stéphane , Haije Wim G. , Louis Benoît 
Published: August 2014

AbstractMethane has proven to be an outstanding energy carrier and is the main component of natural gas and substitute natural gas (SNG). SNG may be synthesized from the CO2 and hydrogen available from various sources and may be introduced into the existing infrastructure used by the natural gas sector for transport and distribution to power plants, industry, and households. Renewable SNG may be generated when H2 is produced from renewable energy sources, such as solar, wind, and hydro. In parallel, the use of CO2‐containing feed streams from fossil origin or preferably, from biomass, permits the avoidance of CO2 emissions. In particular, the biomass‐to‐SNG conversion, combined with the use of renewable H2 obtained by electrolysis, appears a promising way to reduce CO2 emissions considerably, while avoiding energy intensive CO2 separation from the bio feed streams. The existing technologies for the production of SNG are described in this short review, along with the need for renewed research and development efforts to improve the energy efficiency of the renewables‐to‐SNG conversion chain. Innovative technologies aiming at a more efficient management of the heat delivered in the exothermic methanation process are therefore highly desirable. The production of renewable SNG through the Sabatier process is a key process to the transition towards a global sustainable energy system, and is complementary to other renewable energy carriers such as methanol, dimethyl ether, formic acid, and Fischer‐Tropsch fuels.
Representation of the Protein Universe using Classifications, Maps, and Networks
Authors: Ben‐Tal Nir , Kolodny Rachel 
Published: August 2014

AbstractA meaningful and coherent global picture of the protein universe is needed to better understand protein evolution and the underlying biophysics. We survey the studies that tackled this fundamental challenge, providing a glimpse of the protein space. A global picture represents all known local relationships among proteins, and needs to do so in a comprehensive and accurate manner. Three types of global representations can be used: classifications, maps, and networks. In these, the local relationships are derived, based on the similarity of the proteins′ sequences, structures, or functions (or a combination of these). Alternatively, the local relationships can be co‐occurrences of elements in the protein universe. The representations can be based on different objects: full polypeptide chains, fragments, such as structural domains, or even smaller motifs. Different protein qualities were revealed in each study; many point out the uniqueness of domains of the alpha/beta SCOP (structural classification of proteins) class.
Morphological alterations in the synganglion and integument of Rhipicephalus sanguineus ticks exposed to aqueous extracts of neem leaves (Azadirachta indicaA. JUSS)
Authors: Remedio R.N. , Nunes P.H. , Anholeto L.A. , Camargo‐Mathias M.I. 
Published: August 2014

ABSTRACTCurrently, the necessity of controlling infestation by ticks, especially by Rhipicephalus sanguineus, has led researchers and public health managers around the world to search for new and more efficient control methods. This way, we can highlight neem (Azadirachta indica A. Juss) leaf, bark, and seed extracts, which have been very effective on tick control, and moreover causing less damage to the environment and to the host. This study showed the potential of neem as a control method for R. sanguineus through morphological and morphometric evaluation of the integument and synganglion of females, in semiengorged stage. To attain this, routine techniques of optical microscopy, scanning electron microscopy and morphometry of the cuticle and subcuticle of the integument were applied. Expressive morphological alterations were observed in both organs, presenting a dose‐dependent effect. Integument epithelial cells and nerve cells of the synganglion showed signs of cell vacuolation, dilated intercellular boundaries, and cellular disorganization, alterations not previously reported in studies with neem. In addition, variations in subcuticle thickness were also observed. In general, the effects of neem are multiple, and affect the morphology and physiology of target animals in various ways. The results presented in this work are the first evidence of its effects in the coating and nervous system of ticks, thus allowing an indication of neem aqueous extracts as a potential control method of the brown dog tick and opening new perspectives on acaricide use. Microsc. Res. Tech. 77:989–998, 2014. © 2014 Wiley Periodicals, Inc.