bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salmon Calcitonin (Miacalcic NS 200 IU) in Prevention of Bone Loss after Hip Replacement
Authors: Arnala I. O. 
Published: March 2013

Background and Aims: Loosening of a hip prosthesis after total arthroplasty is related to periprosthetic bone loss. Calcitonin has been used in the treatment of bone loss in osteoporosis and prevention of fractures. The main purposes of the study were firstly to evaluate the effect of calcitonin on periprosthetic bone after total hip arthroplasty, secondly investigate possible loosening of the prosthesis and thirdly examine further clinical outcome. Patients and Methods: 60 patients who underwent total hip arthroplasty using cemented Exeter prosthesis were randomized in the treatment group (salmon calcitonin 200 IU nasal spray daily + calcium 500 mg) and the placebo group (inactive nasal spray + calcium 500 mg) for six months. Bone mineral density (BMD) was measured from different locations at the time of discharge and after six and 12 months. Dynamic histomorphometry on bone biopsies taken from femoral collum was performed. Serum bone-specific alkaline phosphatase (BAP), serum osteocalcine (OC) and cross-linked N-telopeptides (NTX) were measured after one week, one month, three months and 12 months. Clinical manifestations and the incidence of fractures and loosening of the prosthesis were followed up to eight years. Results: Statistically there was not significant difference in bone histomorphometry between the groups. In both groups there was a significant BMD decrease in periprosthetic bone. However, the difference between the groups was not statistically significant. In the biochemical analysis NTX increased more in the Miacalcic group than in the placebo group (p = 0.013). There were no significant differences between the groups in serum BAP or OC even though the changes within the groups were statistically significant. No loosening of the prosthesis was seen during the follow-up and there was no need for revision of any reason. Four fractures were recorded in three patients. One patient sustained a periprosthetic fracture. All the patients with fractures were allocated in the placebo group. Conclusions: Nasal salmon calcitonin 200 IU on a daily basis does not promote any additional value on calcium substitution to prevent bone loss after hip replacement. The durability of the Exeter prosthesis was good.
Preoperative Predictors for Good Postoperative Satisfaction and Functional Outcome in Lumbar Spinal Stenosis Surgery — A Prospective Observational Study with a Two-Year Follow-up
Authors: Aalto T. , Sinikallio S. , Kröger H. , Viinamäki H. , Herno A. , Leinonen V. , Turunen V. , Savolainen S. , Airaksinen O. 
Published: March 2013

Background and Aims: Lumbar spinal stenosis (LSS) is the most frequent indication for back surgery in adults aged over 65 years, but about one-third of operated patients have less than good/excellent results from the operation. Awareness of outcome predictors and their predictive values may help clinicians in their assessment of the prognosis of patients when considering surgical treatment. Our aim was to study the preoperative predictors in LSS for a good postoperative outcome (satisfaction with surgery and functional improvement) with a two-year follow-up. Material and Methods: LSS patients (n = 102) completed a questionnaire preoperatively and on two-year follow-up. Preoperative patient-related predictors, self-rated health, comorbidities and preoperative treatment were assessed. Satisfaction with the surgical outcome was assessed with a seven-category scale; satisfaction was determined to be good if the patient response was “condition has considerably improved” or “totally cured”. Other responses (“condition has slightly improved” or worse) represented poorer satisfaction. A good functional outcome was determined as > 30% relative improvement compared to the presurgery score in the Oswestry Disability Index (ODI). Results: The predictors for good satisfaction were age < 75 years at operation (OR 4.03; 95% CI 1.35–12.02; p = 0.012) and no previous lumbar operation (OR 3.65; 95% CI 1.13–11.79; p = 0.031). Predictors for a good improvement in the ODI score were regular preoperative analgesic use < 12 months (OR 3.40; 95% CI 1.21–9.53; p = 0.020), non-smoking (OR 3.47; 95% CI 1.09–11.03; p = 0.035) and good (above average) self-rated health (OR 3.27; 95% CI 1.06–10.12; p = 0.039). Conclusions: In LSS, regular analgesic treatment preoperatively for 12 months or less, self-rated health above average and non-smoking predicted a good postoperative functional improvement. An age under 75 years and no previous lumbar operation predicted good postoperative satisfaction with the surgery.
Medial Malleolar Stress Fracture in Athletes: Diagnosis and Operative Treatment
Authors: Lempainen L. , Liimatainen E. , Heikkilä J. , Alonso J. , Sarimo J. , Mattila K. , Orava S. 
Published: March 2013

Background and Aims: Stress fractures are common overuse injuries in athletes. Medial malleolar stress fractures are rare but they have an important clinical relevance because of their tendency to cause considerable disability and loss of time in sports without proper treatment. The diagnosis of medial malleolar stress fracture is often a challenge and it is therefore often delayed which may cause even further problems in the treatment. The purpose of this study was to increase the awareness of medial malleolar stress fractures as a possible cause for medial ankle pain and to stress the importance of MRI in the diagnostics as well as to evaluate the results of surgical treatment. Patients and Methods: Between 1995 and 2008, a total of ten athletes with a medial malleolar stress fracture were operated at our centre. All operated cases during those years were included in the study. The cases were retrospectively analyzed. Return to pre-injury level of sport was evaluated and considered as an indicator of successful treatment. Results: Initially all standard radiographs were negative whereas in MRI the fractures were all visible. After operative treatment all medial malleolar stress fractures healed clinically in three to four months and all except one of the athletes were able to return to their pre-injury level of sports. Conclusion: Early MRI is recommended if a medial malleolar stress fracture is suspected. Surgical treatment seems to result in rapid healing of the fracture and return to sports. In our opinion early surgery should be considered especially in athletes.
The Mean Seven Years' Results of the Use of Poly-L/D-Lactic Acid (PLDLA) Interposition Implant and Bone Packing in Revision Metacarpophalangeal Arthroplasty: A Prospective Cohort Study
Authors: Tiihonen R. , Honkanen P. B. , Belt E. A. , Ikävalko M. , Skyttä E. T. 
Published: March 2013

Background and Aims: Revision arthroplasty of metacarpophalangeal (MCP) joints in chronic inflammatory arthritis patients after silicone implants is challenging due of severe bone loss and soft tissue deficiencies. The aim of this study was to evaluate the outcome of revision MC Parthroplasty using poly-L/D-lactic acid 96:4 (PLDLA) interposition implant and morcelised allograft or autograft bone packing in patients with failed MCP arthroplasties and severe osteolysis. Material and Methods: The study group consisted of 15 patients (15 hands and 36 joints) at a mean follow-up of seven years (range 5–10 years). The radiographs were reviewed for osteolysis and incorporation of the grafted bone. The clinical assessments included active range of motion, evaluation of pain, subjective outcome and assessment of grip power. Results: PLDLA interposition arthroplasty combined with bone packing provided satisfactory pain relief, but function was limited. Radiographic analysis showed complete incorporation of the grafted bone to the diaphyseal portion of the host metacarpal and phalangeal bones in 30 of the 36 joints. All the patients had very limited grip strength, both on the operated and non-operated side. Conclusions: Due to soft tissue deficiencies long-term function and alignment problems can not be resolved with PLDLA interposition implant.
Single-Incision plus One Port Laparoscopic Anterior Resection for Rectal Cancer as a Reduced Port Surgery
Authors: Hirano Y. , Hattori M. , Douden K. , Shimizu S. , Sato Y. , Maeda K. , Hashizume Y. 
Published: March 2013

Background: Only limited data in the literature about single-incision laparoscopic rectal surgery, because the laparoscopic stapler does not allow low rectal transection without sufficient distal margins from the umbilicus port. We have developed single-incision plus one port laparoscopic anterior resection of the rectum (SILS+1-AR) as a reduced port surgery in which we can utilize the incision for drainage as an additional access route for laparoscopic procedures including the transection the lower rectum. Methods: A Lap protector (LP) mini was inserted through a 2.5 cm transumbilical incision, and an EZ-access was mounted to LP and three 5-mm ports were placed in EZ-access. A 12 mm port was inserted in right lower quadrant. Almost all the procedures were performed with usual laparoscopic instruments, and the operative procedures were much the same as in usual laparoscopic low anterior resection of the rectum using a flexible 5mm scope. The rectum was transected normally using only one endoscopic linear stapler inserted from the right lower quadrant port. Results: We underwent modified SILS+1-AR in 16 patients with advanced rectal cancer. In all cases, there was no need to extend the skin incision. We transected the lower rectum with one laparoscopic stapler in all six cases. Postoperative follow-up did not reveal any umbilical wound complications or recurrences. Conclusions: The safety and feasibility of SILS+1-AR for advanced rectal cancer was established in this study. However, further studies are needed to prove the advantages of this procedure to conventional laparoscopic law anterior resection.
Focused Assessment with Sonography for Trauma in Patients with Confirmed Liver Lesions
Authors: Nielsen S. Kärk , Ewertsen C. , Svendsen L. B. , Hillingsø J. G. , Nielsen M. B. 
Published: March 2013

Background and Aims: The objective was to determine the sensitivity and specificity of Focused Assessment with Sonography for Trauma (FAST) in patients with confirmed liver lesions and also to compare results from surgeons trained in FAST with results from radiologists trained in general abdominal ultrasound as part of the specialist training. Explorative laparotomy or CT served as gold standard. Materials and Methods: This retrospective study included all patients admitted to our institution from 2003 to 2010 registered with the diagnosis “Injury of the liver or gallbladder”. Of 405 patients, 135 patients were eligible for analysis. Seventy-two patients were examined by radiologists and 63 by surgeons. Results: We found FAST to have a sensitivity, specificity, PPV, and NPV of 79.6%, 100%, 100%, and 68.9%. There was no statistically significant difference between FAST performed by radiologists and surgeons trained in FAST. Conclusion: FAST remains an important screening tool in abdominal trauma including liver lesions, and can be performed at a satisfactory level by surgeons trained in the FAST procedure only.
Tension Suture Technique Combined with Lidocain-Adrenalin-Saline-Infiltration Decreases Complications in Abdominoplasty
Authors: Helle M. , Salmi A. , Saariniemi K. , Kuokkanen H. 
Published: March 2013

Backgrounds and Aims: Due to growing interest into body contouring has abdominoplasty become one of the most common aesthetic operations. New techniques have appeared to reduce the relatively high incidence of complications in abdominplasty. One technique is the tension suture technique, which can be combined with lidocain-adrenalin-saline-infiltration. Our aim was to analyse the results of this combined technique. Material and Methods: This retrospective study consisted of 95 women operated on in a private hospital by one senior plastic surgeon between years 2004 and 2009. Sixty patients had other operations in addition to abdominoplasty: 49 liposuctions, six breast reductions or mastopexies, three umbilical hernioplasties, one brachioplasty, one partial excision of labias, and one blepharoplasty. Results and Conclusions: The operative time was 82 minutes ranging from 45 to 173 minutes. Peroperative bleeding was a mean of 196 ml in abdominoplasty only and 254 ml when combined with additional operation. Patients did not have any major complications and the total incidence of minor — not clinically significant — complications was 12.6%. Obesity, smoking, comorbidities, previous operations on belly area or additional operations did not affect the complication rates. Our study supports the view that the tension suture technique combined with lidocain-adrenalin-saline-infiltration decrease the formation of seroma and wound complications in abdominoplasty. Lidocain-adrenalin-saline-infiltration also fastens and eases the operation without increasing the risk of bleeding in experienced hands.
Rising Incidence of Small Size Papillary Thyroid Cancers with No Change in Disease-Specific Survival in Finnish Thyroid Cancer Patients
Authors: Hakala T. , Kellokumpu-Lehtinen P. , Kholová I. , Holli K. , Huhtala H. , Sand J. 
Published: March 2013

Background: The aim of this study was to investigate trends in the incidence, diagnostics, treatment and survival of thyroid cancer in Tampere University Hospital (TAUH) region in recent decades. Material and Methods: New thyroid cancer cases from 1981 to 2002 were ascertained from the Finnish Cancer Registry. Follow-up data was collected from medical records of TAUH. Differentiated thyroid cancer (DTC; consisting of papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC)) patients' data was analyzed and divided into two equal time periods (1981–1991 and 1992–2002). Results: The total amount of thyroid cancer cases was 553, of which 427 (77%) were papillary and 72 (13%) follicular. Thyroid cancer was four times more common in females than in males and the median age at the time of diagnosis was 52 years. The incidence of DTC was 4.5/100 000 in the earlier group and 6.0/100 000 in the later group (IRR 1.33, CI 1.11–1.60). The proportion of papillary thyroid cancer rose from 81% to 89% (p = 0.02) in two study periods. Median tumour size became smaller, from 25 mm to 15 mm (p < 0.001). Surgery became more radical as total thyroidectomies were performed almost exclusively on the later group (p < 0.001). Median cumulative dose of radioiodine (I131) therapy was higher in the later group (p = 0.04). There was no difference in number of cancer recurrences (p = 0.54). The prognosis of DTC was good; 10-year disease-specific survival was 92% in the earlier group and 94% in the later group (p = 0.43). Conclusions: The incidence of thyroid cancer has risen and proportion of papillary cancer has increased, however, median size of tumour has decreased. No difference was seen in either all-cause or disease-specific survival.
The development of resilience in social work students and professionals
Authors: de las Olas Palma-García Maria , Hombrados-Mendieta Isabel 
Published: March 2013

Summary This study analyzes whether resilience, defined as a process rather than as a static response over time, is associated with social work. The main aim was to determine whether social work increases resilience in students and professionals during training and when practicing the profession. The sample consisted of 613 university students and professionals from Malaga (Spain). Findings The longitudinal study of social work students indicated statistically significant within-subjects differences during their university course in the components of resilience (personal competence, acceptance of self and life, and social support). Regarding professionals, the results show a positive association between years of experience and their acceptance of self and life and coping with workplace adversity. Applications Implications include the need to focus on the development of positive experiences during training and the practice of social work, such as the capacity to be resilient.
Using a Bone Allograft to Fixate Proximal Interphalangeal Joint Arthrodesis
Authors: Kominsky Stephen J. , Bermudez Roberto , Bannerjee Alvin 
Published: March 2013

Digital contractures are a very common deformity of the foot and ankle that require surgical correction. It has been shown that arthrodesis provides a better long-term result than arthroplasty of the interphalangeal joints. Arthroplasties usually require K-wire fixation that presents potential complications, such as pin tract infection. This study presents a new cadaveric bone matrix allograft to be used as rigid internal fixation for proximal interphalangeal joint arthrodesis. The purpose of using the allograft as a fixation device is to achieve solid bone fusion and avoid the potential complications of external pin fixation. Arthrodesis of the proximal interphalangeal joint was performed on 63 toes in 32 patients using TenFUSE (Solana Surgical, Memphis, TN), a sterile bone matrix allograft. The authors found 97% fusion rate with no complications reported to this date. It was concluded that this bone matrix allograft provides excellent results and is a suitable alternative fixation device for correction of hammer toe deformity. Level of Evidence: Level V
Activity-Related Outcomes of Articular Cartilage Surgery
Authors: Chalmers Peter N. , Vigneswaran Hari , Harris Joshua D. , Cole Brian J. 
Published: March 2013

Objective: The purpose of this systematic review was to compare activity-based outcomes after microfracture, autologous chondrocyte implantation (ACI), and osteochondral autograft (OAT). Design: Multiple databases were searched with specific inclusion and exclusion criteria for level III and higher studies with activity outcomes after microfracture, OAT, osteochondral allograft, and ACI. Activity-based outcomes included the Knee Injury and Osteoarthritis Outcome Score (KOOS), the Tegner Score, the Cincinnati Knee scores, the International Knee Documentation Committee (IKDC) subjective knee score, the Marx activity score, and/or the rate of return-to-sport. Results: Twenty studies were included (1,375 patients). Although results were heterogeneous, significant advantages were seen for ACI and OAT as compared with microfracture in Tegner scores at 1 year (ACI vs. microfracture, P = 0.0016), IKDC scores at 2 years (ACI vs microfracture, P = 0.046), Lysholm scores at 1 year (OAT vs microfracture, P = 0.032), and Marx scores at 2 years (OAT vs microfracture, P < 0.001). The only score or time point to favor microfracture was Lysholm score at 1 year (ACI vs microfracture, P = 0.037). No other standardized outcome measures or time points were significantly different. Several studies demonstrated significantly earlier return to competition with microfracture. Overall reoperation rates were similar, but of reoperations, a higher proportion of those following ACI were unplanned with the majority of performed for graft delamination or hypertrophy. Conclusions: ACI and OAT may have some benefits over microfracture, although return-to-sport is fastest following microfracture. Heterogeneity in technique, outcome measures, and patient populations hampers systematic comparison within the current literature.
Has the incidence of urolithiasis presenting to secondary care increased in the last 10 years?
Authors: Mangera A , Khan K , Parys BT 
Published: March 2013

Objective: Urolithiasis presenting to secondary care has been proposed to be on the increase, in the United Kingdom, based on national Hospital Episode Statistics data. We aimed to assess whether there has been an increase in stone disease presenting to a district general hospital in the last 10 years. Methods: A prospective stone database has been kept for all patients attending the urology department of a district general hospital from 2002. We assessed five yearly intervals to identify changes in incidence, gender and age distribution, and stone composition rates. Results: A 26% increase in calculi presenting to the urology department was noted in the last 10 years. This was in relation to a 2% population increase. This also resulted in a 26% increase in operations for urinary calculi. The increases were equal for men and women, and the mean age of presentation remained the same. There were no significant differences in the findings of stone composition in the last 10 years or in the surgical method of stone extraction. Conclusion: Urolithiasis presenting to the urologist is on the increase, leading to a greater need for urological procedures. Stone services may need to be increased to deal with this increasing demand.
Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors
Authors: Altman Jessica K. , Szilard Amy , Konicek Bruce W. , Iversen Philip W. , Kroczynska Barbara , Glaser Heather , Sassano Antonella , Vakana Eliza , Graff Jeremy R. , Platanias Leonidas C. 
Published: March 2013

Key Points
The Mnk inhibitor cercosporamide suppresses human leukemic progenitors and exhibits antileukemic effects in a xenograft mouse model. Cercosporamide enhances the antileukemic effects of cytarabine in vitro and in vivo.
Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells
Authors: Karlsson Christine , Baudet Aurélie , Miharada Natsumi , Soneji Shamit , Gupta Rajeev , Magnusson Mattias , Enver Tariq , Karlsson Göran , Larsson Jonas 
Published: March 2013

Key Points
Chemokine (C-C motif) ligand 28 (CCL28) is a novel growth factor for human hematopoietic stem and progenitor cells. CCL28 supports the in vitro and in vivo functional integrity of cultured primitive hematopoietic cells.
Circuit lengths of graphs for the Picard group
Authors: Beşenk Murat , Güler Bahadır Ö , Değer Ali H , Kesicioğlu Yavuz 
Published: March 2013

Abstract
In this paper, we examine some properties of suborbital graphs for the Picard group. We obtain edge and circuit conditions, then propose a conjecture for the graph to be forest. This paper is an extension of some results in (Jones et al. in The Modular Group and Generalized Farey Graphs, pp. 316-338, 1991).
Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression
Authors: Yu Beiqin , Chen Xuehua , Li Jianfang , Qu Ying , Su Liping , Peng Yibing , Huang Jian , Yan Jun , Yu Yingyan , Gu Qinlong , Zhu Zhenggang , Liu Bingya 
Published: March 2013

Abstract

Background
Fibroblasts play a critical role in tumorigenesis, tumor progression and metastasis. However, their detailed molecular characteristics and clinical significance are still elusive. TAGLN is an actin-binding protein that plays an important role in tumorigenesis.

Results
We investigated the interaction between cancer cells and the tumor microenvironment to determine how the fibroblasts from human gastric carcinoma facilitate tumorigenesis through TAGLN. QRT-PCR and Western blot indicated that TAGLN expression was upregulated in gastric carcinoma-associated fibroblasts (CAFs) that promote gastric cancer cell migration and invasion. Using small interfering RNA (siRNA), we found that CAFs enhanced tumor metastasis through upregulated TAGLN in vitro and in vivo. The expression of matrix metalloproteinase-2 (MMP-2) was significantly lower after TAGLN knock-down by siRNA. TAGLN levels were elevated in human gastric cancer stroma than normal gastric stroma and associated with differentiation and lymph node metastasis of gastric cancer.

Conclusion
CAFs may promote gastric cancer cell migration and invasion via upregulating TAGLN and TAGLN induced MMP-2 production.