bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic adrenalectomy performed by a general surgeon on functioning adrenal tumors: Treatment outcomes and risk prediction of persistent hypertension
Authors: Tullavardhana Thawatchai 
Published: August 2024

Background: Functional adrenal tumors may contribute to poor hypertension control and electrolyte abnormalities, thus increasing the risk of cardiovascular mortality. Currently, laparoscopic adrenalectomy is an effective surgical option that contributes to improved treatment outcomes as compared to open surgery. The purpose of this study was to evaluate the outcomes of laparoscopic adrenalectomy performed by a general surgeon at a low-volume center and to identify clinicopathological risk factors for postoperative persistent hypertension.
Methods: A retrospective study of patients with functional adrenal tumors who underwent laparoscopic adrenalectomy at Srinakharinwirot University, Thailand, between 2014 and 2022. Clinicopathologic and postoperative data were examined.
Results: This study included twenty-five patients; the indications for laparoscopic adrenalectomy included primary aldosteronism in 19 (76%), pheochromocytoma in 4 (16%), and Cushing’s syndrome in 2 (8%). The average time of surgery was 103.5 ± 19.7 min, and intraoperative complications occurred in three patients (12%), with one patient requiring conversion to open surgery (4%). The postoperative systolic (125 ± 15 vs. 158 ± 18 mmHg; p < 0.001) and diastolic (78.5 ± 6.7 vs. 95.3 ± 10 mmHg; p = 0.013) blood pressure significantly decreased compared to prior surgery, but only 19 patients (76%) achieved a cure for hypertension. Multivariate analysis revealed that the patient’s physical status, as classified by the American Society of Anesthesiologists (odds ratio (OR) = 0.66, 95% confidence interval (CI) 0.43–1.32, p = 0.001), and the need for at least three antihypertensive medicines (OR = 0.7, 95% CI 0.36–1.2, p = 0.002), were independent predictive factors of persistent hypertension after surgery.
Conclusion: Laparoscopic adrenalectomy is a safe and effective surgical treatment for functional adrenal tumors, even when performed in a low-volume center. According to the American Society of Anesthesiologists’ physical categorization, the patient’s physical condition and the necessity for at least three antihypertensive medications are predictors of postoperative hypertension.
Trial registration: The study was registered with the Thai Clinical Registry Trials: TCTR20230707007.
PENINGKATAN PENGETAHUAN KADER LANSIA DALAM MENGONTROL REGULASI TEKANAN DARAH PADA PASIEN HIPERTENSI DI DUSUN CANGKRING DESA PELEM KECAMATAN PARE KABUPATEN KEDIRI
Authors: Erni Rahmawati  , Rahayu Dwi , Astri Yunita  , Didik Susetiyanto Atmojo  , Erwin Yektiningsih  
Published: August 2024

Abstrak
Masalah utama di berbagai negara yang berkaitan dengan kesehatan adalah penyakit jantung dan pembuluh darah. Hipertensi merupakan salah satu pemicu terjadinya kematian pertama di dunia per tahunnya. Angka penderita hipertensi terus mengalami peningkatan setiap tahunnya. Diperkirakan pada tahun 2025 akan ada 1,5 miliar orang yang menderita hipertensi, dan diprediksi per tahunnya 10,44 juta orang meninggal yang disebabkan karena hipertensi dan komplikasinya. Manajemen hipertensi dapat dilakukan dari pengetahuan lansia mengenai hipertensi serta pengaturan diet hipertensi. Kegiatan yang telah dilakukan yaitu memberikan pendidikan kesehatan terkait penyakit hipertensi, pemeriksaan tekanan darah, tehnik relaksasi otot progresif, dan diberi pemahaman tentang pembuatan jus timun dan belimbing untuk mengontrol hipertensi. Tujuan dari kegiatan ini diharapkan ada peningkatan pengetahuan, pada lansia sehingga menyadari pentingnya menjaga tekanan darah yang dialami saat ini. Kegiatan dilaksanakan pada bulan Agustus 2023. Dari 60 lansia yang hadir, ditemukan 40 orang lansia dengan tekanan darah diatas normal (140/90mmHg). Hal ini dapat dikatakan prevalensi yang memiliki hipertensi hanya 37,3%, dikarenakan lansia lainnya telah terkontrol dengan menggunakan obat anti hipertensi yang diberikan dari Puskesmas Bendo.
Kata kunci : Pengetahuan, Lansia, Hipertensi
Abstract
The main problem in various countries related to health is heart and blood vessel disease. Hypertension is one of the causes of the first death in the world every year. The number of hypertension sufferers continues to increase every year. It is estimated that by 2025 there will be 1.5 billion people suffering from hypertension, and it is predicted that 10.44 million people will die each year due to hypertension and its complications. Hypertension management can be done from the elderly's knowledge about hypertension and managing the hypertension diet. The activities that have been carried out include providing health education related to hypertension, checking blood pressure, progressive muscle relaxation techniques, and providing an understanding of making cucumber and star fruit juice to control hypertension. The aim of this activity is expected to increase knowledge in the elderly so that they realize the importance of maintaining their current blood pressure. The activity was held in August 2023. Of the 60 elderly people who attended, 40 elderly people were found with blood pressure above normal (140/90mmHg). It can be said that the prevalence of hypertension is only 37.3%, because other elderly people have been controlled using anti-hypertension drugs given from the Bendo Community Health Center.
Keywords: Knowledge, Elderly, Hypertension
Efektivitas Pelaksanaan Aplikasi Galamai (Galeri Layanan Masyarakat dan Informasi) Pada Balai Besar Pengawas Obat dan Makanan di Padang
Authors: Septia Warman Nabila , Aldri Frinaldi  
Published: August 2024

Penyelenggara pelayanan publik ialah suatu pemenuhan kebutuhan dasar setiap masyarakat oleh pemerintah. Balai besar pengawas obat dan Makanan (BBPOM) di Padang adalah institusi pemerintahan non-kementerian untuk melayani masyarakat mengenai izin yang terkait di bidang Obat dan Makanan. Oleh hal tersebut BBPOM di Padang membuat suatu program pelayanan publik yaitu Aplikasi Galamai (Galeri Layanan Masyarakat dan Informasi). Penelitian ini bertujuan untuk menganalisis efektivitas pelaksanaan aplikasi Galamai pada BBPOM di Padang, mengidentifikasi kendala dalam pelaksanaan serta upaya untuk mengatasinya. Studi ini berjenis kualitatif menggunakan pendekatan deskriptif dan sudut pustaka serta studi wawancara, dokumentasi dan observasi non partisipan. Hasil studi menjelaskan bahwasanya pelaksanaan aplikasi Galamai pada BBPOM di Padang telah berjalan optimal akan tetapi untuk kegiatannya ada beberapa permasalahan yang mempengaruhi implementasinya yang dinilai tidak cukup efektif. Berdasarkan data dilapangan, masih ada masyarakat dan stakeholders serta para pegawai yang mengeluhkan kendala diantaranya tidak dapat diaksesnya aplikasi Galamai sendiri, terkendala sinyal yang mengakibatkan terhentinya kegiatan pelayanan. Dari hasil tersebut dapat dikatakan pelaksanaan aplikasi Galamai sudah baik, namun belum cukup dikatakan efektif.
Pengetahuan Dan Sikap Perawat Pelaksana Dalam Memberikan Discharge Planning Di Ruang Rawat Inap Rumah Sakit Ibnu Sina Kabupaten Pidie
Authors: Ismutania Ismutania 
Published: August 2024

Latar belakang: discharge planning pasien dapat memberikan motivasi untuk mencapai kesembuhan, dapat memberikan dampak terhadap pemendekan lama perawatan pasien di rumah sakit, menurunkan anggaran kebutuhan rumah sakit, menurunkan angka kekambuhan, dan memungkinkan intervensi rencana pulang dilakukan tepat waktu. Tujuan: ntuk mengidentifikasi pengetahuan dan sikap perawat pelaksana tentang discharge planning di Ruang Rawat Inap RSU. Ibnu Sina Kabupaten Pidie. Metode: menggunakan desain penelitian deskriptif untuk melihat gambaran pengetahuan dan sikap perawat dalam memberikan discharge planning. Sampel yang digunakan sebgaai 32 perawat dengan menggunakan metode sampling yaktu total sampling. Hasil penelitian: gambaran pengetahuan perawat tentang discharge planning ialah kategori baik sebanyak 18 orang (56,3%), kategori cukup sebanyak 10 orang (31,2%), dan kategori kurang sebanyak 4 orang (12,5%). Selanjutnya, gambaran sikap perawat dalam melaksanakan discharge planning ialah kategori sikap positif sebanyak 21 orang (65,6%), kategori sikap negatif sebanyak 11 orang (34,4%). Saran: disarankan kepada perawat agar dapat memanfaatkan hasil penelitian ini sebagai sumber informasi dalam upaya peningkatan kualitas pelayanan kepada pasien, bukan hanya pada saat pasien datang ke rumah sakit tetapi juga pada saat pasien akan pulang juga harus diberikan discharge planning sehingga tingkat kemandirian pasien menjadi lebih baik
Hubungan Kepatuhan Diet Pada Pasien Diabetes Melitus Tipe II Dengan Penyembuhan Luka Diabetik
Authors: Maulidya Riski 
Published: August 2024

Kepatuhan terhadap diet makanan dan minuman yang dikonsumsi pasien DM setiap hari untuk menjaga kesehatan dan mempercepat proses penyembuhan luka, berupa 3J yaitu : tepat jadwal, tepat jenis dan tepat jumlah. Ketidakpatuhan diet pada akhirnya dapat memperburuk kondisi pasien dan dapat menimbulkan komplikasi. Desain penelitian menggunakan deskriptif korelatif dengan pendekatan cross sectional. Sampel penelitian ini berjumlah 49 responden dan menggunakan alat ukur food recall dan lembar ceklis obeservasi luka. Analisa data menggunakan uji statistic dengan kemaknaan α = 0,05. Hasil penelitian menunjukkan hasil uji statistic chi-square diperoleh nilai p-value = 0.000 < α (0.05). Sehingga dapat disimpulkan bahwa ada hubungan antara kepatuhan diet pada pasien DM tipe II dengan penyembuhan luka diabetik di klinik perawatan luka Alhuda Wound Care.Simpulan dari penelitian ini membuktikan bahwa terdapat adanya hubungan yang signifikan antara kepatuhan diet pasien DM dengan proses penyembuhan luka diabetik, dimana semakin tidak patuh pasien DM terhadap dietnya maka penyembuhan luka akan semakin lambat.
Psychological intervention based on social cognitive theory: Treating pain, anxiety, and depression in perioperative patients
Authors: Mao Hai-Jian , Wang Lin-Fei , Lin Chun 
Published: August 2024

BACKGROUND
Surgery is an effective method for treating certain diseases. Factors such as disease, preoperative fear and tension, surgical stress, postoperative pain, and related complications directly affect the smooth progression and outcome of surgery. Patients may experience a series of psychological and physiological changes during the perioperative period, resulting in anxiety and depression, which may reduce the pain threshold and worsen their prognosis.
AIM
To investigate the effects of a psychological intervention among perioperative patients, based on social cognitive theory (SCT).
METHODS
We enrolled 200 patients who underwent surgical care at The First People’s Hospital of Lin’an District, Hangzhou between January and December 2023. They were categorized into a routine intervention group (n = 103) and a psychological intervention group (n = 97), based on the intervention strategies used. Various assessment tools, including the self-rating anxiety scale (SAS), the self-rating depression scale (SDS), and the Connor–Davidson Resilience scale, were used to measure patients’ negative states and emotions. The pre- and post-intervention scores for these metrics in the two groups were then analyzed.
RESULTS
In the psychological intervention group, the SAS and SDS scores (31.56 ± 5.18 and 31.46 ± 4.57, respectively) were significantly reduced compared to the routine intervention group (P < 0.05). The visual analog scale pain scores at 12 and 24 hours after intervention (6.85 ± 1.21, 4.24 ± 0.72) were notably higher than those in the routine intervention group (P < 0.05). The psychological intervention group also demonstrated superior scores in perseverance (36.08 ± 3.29), self-reliance (22.63 ± 2.91), optimism (11.42 ± 1.98), and resilience (70.13 ± 5.37), compared to the routine intervention group (P < 0.05). Additionally, the psychological intervention group’s confrontation score (23.16 ± 4.29) was higher (P < 0.05). This group also reported lower scores in avoidance (9.28 ± 1.94) and yielding (6.19 ± 1.92) (P < 0.05). Lastly, the Short Form 36 Health Survey scores were significantly higher in the psychological intervention group, indicating a better quality of life (P < 0.05).
CONCLUSION
Psychological intervention measures based on SCT can effectively alleviate pain, anxiety, and depression in perioperative patients.
Pengembangan Wisata Danau Letang dalam Upaya Peningkatan Ekonomi Masyarakat di Kabupaten Batanghari
Authors: Ovie Yanti  , Musyaiyadah Musyaiyadah  
Published: August 2024

Batanghari Regency has quite a lot of tourism potential that can be developed, such as an exotic urban forest atmosphere, a lake surrounded by bushes and a cool and comfortable atmosphere, making it a special attraction for visitors. The plan to develop tourism potential in Batanghari Regency has been ongoing for a long time. However, this arrangement has only been implemented since 2021. The Batanghari Regency Government is committed to making tourism in Batanghari Regency a combination of beautiful and unique nature with local cultural wisdom to improve the economy of the community. This research describe the development of tourism potential in improving the community economy in Batanghari Regency and identify the obstacles faced. This research takes a qualitative approach. Data collecting methods included observation, interviews, and documentation. The data obtained in this research were analyzed using the interactive model proposed by Miles also Huberman, This comprises data reduction, presentation, and making conclusions.
PENDIDIKAN KESEHATAN TENTANG PENYUSUNAN MENU SEIMBANG PADA IBU BALITA USIA 3-5 TAHUN DALAM PENCEGAHAN DINI STUNTING DI PUSKESMAS RAYA PEMATANGSIANTAR
Authors: Shanty Maria Lissanora Fernanda  , Norong  Perangin-angin  , Yohanna Adelina Pasaribu  
Published: August 2024

Tujuan pengabdian masyarakat ini untuk memberikan edukasi kepada ibu balita mengenai kebutuhan Gizi pada anak untuk penanganan dan pencegahan stunting yang memberikan pengaruh pada pertumbuhan anak yang akan menurunkan angka stunting. Kaum ibu yang berada di wilayah desa Kubang Jaya merupakan bagian dari sasaran untuk dilakukan penyuluhan mengenai MP-ASI dikarenakan masih terdapat beberapa anak yang berusia 0 -24 bulan. Tujuan umum Untuk memberikan Pendidikan Kesehatan masyarakat dalam penyusunan menu seimbang pada ibu balita 3-5 tahun dalam pencegahan dini stunting di puskesmas raya pematangsiantar. serta meningkatkan pemahaman dan cara menjaga kesehatan pada ibu balita di puskesmas raya pematangsiantar. Hasil kegiatan Program Pengabdian Masyarakat yang telah dilakukan, dapat disimpulkan bahwa terjadi peningkatan pengetahuan atau pemahaman masyarakat tentang penyusunan menu seimbang pada ibu balita di puskesmas raya Pematangsiantar
Pemeriksaan Hb Dan Edukasi Anemia Pada Remaja Putri Di Daerah Pesisir Pantai
Authors: Dyta Anggraeny  , Lisa Ardiningtyas  , Rodela Agnesia Irot  
Published: August 2024

Masalah global terkait dengan gizi salah satunya yaitu anemia defisiensi besi. Anemia menjadi salah satu risiko terjadinya permasalahan gizi lainnya seperti stunting, berat badan lahir rendah dan saling terkait dengan pemberian ASI Eksklusif serta kejadian wasting. Anemia masih menjadi salah satu permasalahan kesehatan dunia terutama di negara-negara berkembang, tidak terkecuali Indonesia. Perempuan berisiko lebih tinggi dibandingkan laki-laki mengalami anemia dikarenakan adanya siklus menstruasi. Masa remaja menjadi salah satu perhatian terkait permasalahan anemia dikarenakan masa tersebut menjadi pencetus untuk menghasilkan generasi selanjutnya. Letak geografis di daerah pesisir pantai juga bisa menjadi salah satu risiko terjadinya peningkatan kejadian anemia. Metode yang digunakan pada kegiatan ini berupa pemeriksaan Hb pada remaja putri yang telah menstruasi, edukasi kepada seluruh remaja putri serta pembagian leaflet, dan pembagian kuesioner untuk mengetahui dampak dari pemberian edukasi. Sasaran kegiatan ini ditujukan kepada Remaja putri di SMP Negeri 9 Bitung. Hasil menunjukkan terdapat 5% yang mengalami anemia, hasil pre test (sebelum dilakukan edukasi) yaitu baik 14,28%, cukup 42,86% dan kurang 42,86% sedangkan hasil post test (sesudah edukasi) mengalami peningkatan menjadi tingkat pengetahuan baik 57,14%, cukup 33,33% dan kurang 9,53%. Kesimpulan bahwa persentase anemia minim dan pemberian edukasi secara lisan dan pembagian leaflet kepada remaja putri di Kelurahan Mawali Kecamatan Lembeh Utara Kota Bitung berhasil.
Pemanfaatan Daging dan Limbah Tulang Ikan sebagai Sumber Protein, Kalsium dan Fosfor (Bagi Warga Kelurahan Batukota, Kecamatan Lembeh Utara)
Authors: Febrianika Ayu Kusumaningtyas  , Rizkan Halalan Djafar  
Published: August 2024

Kegiatan Pengabdian pada Masyarakat telah dilaksanakan di Kelurahan Batukota, Kecamatan Lembeh Utara, Kota Bitung, di mana masyarakat yang tinggal di daerah ini Sebagian besar bermata pencarian sebagai nelayan. Ikan merupakan hasil laut terbanyak yang diperoleh nelayan dan dijadikan komoditas jual beli, yang juga untuk dikonsumsi keluarga. Pengolahan daging ikan di daerah ini perlu diperbarui dengan melakukan pelatihan pengolahan daging ikan menjadi bakso dan nugget. Tulang ikan yang umumnya hanya menjadi limbah rumah tangga yang dibuang diolah menjadi kerupuk dengan kandungan utama kalsium dan fosfor yang sangat baik bagi tubuh. Metode yang diadopsi dalam kegiatan ini yakni direct learning dan simulasi yang langsung dipraktekkan oleh warga. Hasil akhir dari kegiatan pelatihan adalah terampil dan mampunya warga mengolah daging dan tulang ikan dengan lebih efisien dan optimal.
The maze of real-world evidence frameworks: from a desert to a jungle! An environmental scan and comparison across regulatory and health technology assessment agencies
Authors: Sarri Grammati , Hernandez Luis G 
Published: August 2024

Aim:
Regulatory and health technology assessment (HTA) agencies have increasingly published frameworks, guidelines, and recommendations for the use of real-world evidence (RWE) in healthcare decision-making. Variations in the scope and content of these documents, with updates running in parallel, may create challenges for their implementation especially during the market authorization and reimbursement phases of a medicine's life cycle. This environmental scan aimed to comprehensively identify and summarize the guidance documents for RWE developed by most well-established regulatory and reimbursement agencies, as well as other organizations focused on healthcare decision-making, and present their similarities and differences.
Methods:
RWE guidance documents, including white papers from regulatory and HTA agencies, were reviewed in March 2024. Data on scope and recommendations from each body were extracted by two reviewers and similarities and differences were summarized across four topics: study planning, choosing fit-for-purpose data, study conduct, and reporting. Post-authorization or non-pharmacological guidance was excluded.
Results:
Forty-six documents were identified across multiple agencies; US FDA produced the most RWE-related guidance. All agencies addressed specific and often similar methodological issues related to study design, data fitness-for-purpose, reliability, and reproducibility, although inconsistency in terminologies on these topics was noted. Two HTA bodies (National Institute for Health and Care Excellence [NICE] and Canada's Drug Agency) each centralized all related RWE guidance under a unified framework. RWE quality tools and checklists were not consistently named and some differences in preferences were noted. European Medicines Agency, NICE, Haute Autorité de Santé, and the Institute for Quality and Efficiency in Health Care included specific recommendations on the use of analytical approaches to address RWE complexities and increase trust in its findings.
Conclusion:
Similarities in agencies' expectations on RWE studies design, quality elements, and reporting will facilitate evidence generation strategy and activities for manufacturers facing multiple, including global, regulatory and reimbursement submissions and re-submissions. A strong preference by decision-making bodies for local real-world data generation may hinder opportunities for data sharing and outputs from international federated data networks. Closer collaboration between decision-making agencies towards a harmonized RWE roadmap, which can be centrally preserved in a living mode, will provide manufacturers and researchers clarity on minimum acceptance requirements and expectations, especially as novel methodologies for RWE generation are rapidly emerging.
An international observational study assessing conservative management in hemorrhoidal disease: results of CHORALIS (aCute HemORrhoidal disease evALuation International Study)
Authors: Godeberge Philippe , Csiki Zoltan , Zakharash Mykhailo , Opot Elly Nyaim , Shelygin Yuri A , Nguyen Trung Tin , Amir Ashraf , Konaté Ibrahima , Momoh Moses , Chirol Joanna , Blanc-Guillemaud Vanessa , Donglin Ren 
Published: August 2024

Aim:
Real-world evidence on the management of hemorrhoidal disease (HD) is limited. This international study collected clinical practice data on the effectiveness of conservative treatments for acute HD on symptoms and quality of life (QoL), providing perspectives of treatment modalities from different continents.
Patients & methods:
The 4-week observational prospective CHORALIS study involved adult outpatients consulting for spontaneous complaints of hemorrhoids (graded using Goligher classification) and prescribed conservative treatments according to usual clinical practice. Assessments were: anal pain/discomfort (visual analog scale [VAS]), other signs/symptoms (patient questionnaire), Patient Global Impression of Change (PGI-C) questionnaire and disease-specific QoL (HEMO-FISS-QoL questionnaire).
Results:
Of 3592 participants, 3505 were analyzed (58.4% male; age 40.5 ± 13.7 years; history of HD in 48.4%; 72.1% Goligher grade I and II). Pain and discomfort were the most common symptoms. Most treatments were venoactive drugs (VADs; 90.9%), particularly micronized purified flavonoid fraction (MPFF; 73.7%) and diosmin (14.6%). All VAD-based therapies improved signs/symptoms (number/intensity/frequency of pain, discomfort, bleeding, swelling, itching and soiling) and QoL. MPFF was associated with a significantly greater proportion of patients with no symptoms (48.8 vs diosmin 34.4%, p < 0.001), pain disappearance (69.7 vs diosmin 52.8%, p < 0.001), treatment impact at 1 week rated on PGI-C as ‘very much better’ (30.5 vs diosmin 17.9%, p < 0.001) and shorter times to improvement (mean ± SD 3.9 ± 1.5 days vs diosmin 4.2 ± 1.7 days).
Conclusion:
In this prospective real-world study of patients with acute HD, conservative therapies consisting mainly of VADs, including MPFF, improved the clinical signs and symptoms of disease, as well as QoL. This study evidence supports clinical advantages associated with VADs, mostly MPFF, for effectively managing acute HD.