bluuebunny/crossref_metadata_2025_split huggingface dataset:
A POLÍTICA NACIONAL DE SANEAMENTO BÁSICO: UMA ANÁLISE COM BASE NO CASO DOS MUNICÍPIOS DE FRANCISCO BELTRÃO, IRETAMA E CAMPO MOURÃO/PR
Authors: Athaydes Tiago Vinicius Silva 
Published: July 2024

A falta de políticas municipais voltadas para o atendimento do saneamento básico é algo que ainda prejudica a população brasileira e mundial. Ao menos no papel, o PLANSAB -Plano Nacional de Saneamento Básico tem como meta ampliar a participação de estados e municípios, descentralizando ações e incentivando a construção de planos e políticas municipais de saneamento. Neste artigo, são apresentados os fundamentos do PLANSAB, com ênfase em diretrizes para o saneamento no meio rural, e analisada a existência de políticas e ações na área de disposição e tratamento de esgoto em três municípios no estado do Paraná: Francisco Beltrão, Iretama e Campo Mourão. A metodologia utilizada foi composta por revisão bibliográfica; leitura e análise da Lei n. 11445/2007, que culminou na criação do PLANSAB em 2013; revisão do PLANSAB em 2019; e em entrevistas com responsáveis pelo desenvolvimento de ações de saneamento rural de cada município. Como o PLANSAB trata de políticas e práticas para o saneamento em nível municipal, buscou-se entender como os municípios estão enfrentando essas questões. Os municípios estudados não apresentaram planos e políticas municipais para o saneamento básico no meio rural, não seguindo as diretrizes do Plano e da Política Nacional de Saneamento Básico.

Palavras-chave: Relação Sociedade e Natureza. Saneamento Básico. Agricultura Familiar. Políticas Públicas.
RELAÇÃO ENTRE CHEIAS E INDICADORES DO NÍVEL DE MARGENS PLENAS EM UM CÓRREGO PERIURBANO DE MARECHAL CÂNDIDO RONDON, OESTE DO PARANÁ
Authors: Fernandez Oscar Vicente Quinonez 
Published: July 2024

A definição do nível de margens plenas em canais entalhados é um problema recorrente nas medições de campo. O trabalho analisa a relação da frequência e da magnitude das cheias com indicadores morfológicos e sedimentológicos do nível de margens plenas no córrego Guavirá em Marechal Cândido Rondon (PR). O estudo foi realizado em um trecho entalhado ao longo de 80 m de extensão e área de bacia igual a 8,31 km2. O estudo consistiu no levantamento de perfis longitudinal e transversal e monitoramento das cheias com réguas de máximas entre 2006 e 2013. Nos perfis foram identificados diversos indicadores comumente utilizados na literatura: depósito lateral de canal (H1), cota superior da faixa de desgaste (H2), ponto de inflexão da margem (H3) e superfície do fundo de vale (H4). Foram registradas 182 enchentes, com vazões mínima e máxima igual a 3,27 e 33,90 m3/s e valores da média, mediana e moda igual a 4,58, 4,12 e 3,45 m3/s respectivamente. A comparação das estatísticas das cheias com as posições altimétricas dos indicadores sugere que as feições H1 e H2, que coincidem com a moda e a mediana das cheias, podem ser usados como indicadores do nível de margens plenas nos canais entalhados da região.

Palavras-chave: Fundo de vale. Planície de inundação. Canal incisivo. Urbanização.
Palmitoylation of NLRP3 Modulates Inflammasome Activation and Inflammatory Bowel Disease Development
Authors: Hu Dingwen , Li Yuting , Wang Xianyang , Zou Haimei , Li Zonghui , Chen Weijie , Meng Yu , Wang Yingchong , Li Qin , Liao Feng , Wu Kailang , Wu Jianguo , Li Geng , Wang Wenbiao 
Published: July 2024

Abstract
Aberrant activity of NLRP3 has been shown associations with severe diseases. Palmitoylation is a kind of protein post-translational modification, which has been shown to regulate cancer development and the innate immune system. Here, we showed that NLRP3 is palmitoylated at Cys419 and that palmitoyltransferase ZDHHC17 is the predominant enzyme that mediates NLRP3 palmitoylation and promotes NLRP3 activation by interacting with NLRP3 and facilitating NIMA-related kinase 7 (NEK7)–NLRP3 interactions. Blockade of NLRP3 palmitoylation by a palmitoylation inhibitor, 2-bromopalmitate, effectively inhibited NLRP3 activation in vitro. Also, in a dextran sulfate sodium–induced colitis model in mice, 2-bromopalmitate application could attenuate weight loss, improve the survival rate, and rescue pathological changes in the colon of mice. Overall, our study reveals that palmitoylation of NLPR3 modulates inflammasome activation and inflammatory bowel disease development. We propose that drugs targeting NLRP3 palmitoylation could be promising candidates in the treatment of NLRP3-mediated inflammatory diseases.
Outcome after total knee arthroplasty with or without patellar resurfacing
Authors: Chaudhary Deepinder , Siddiqui Md Shahbaz , Rana Nipun , Nagi Onkar Nath 
Published: July 2024

Background:
Anterior knee pain is one of the most important nagging factors following ‘total knee arthroplasty’. It requires adequate redressal to avoid patient dissatisfaction, undue psychological stresses and inflated costs due to readmission and reoperation.

Aims:
To assess the functional outcome prospectively in total knee arthroplasty with or without patellar resurfacing.

Materials and Methods:
A prospective randomised study involving 25 patients undergoing bilateral total knee arthroplasty (TKA) was carried out to study the outcome after TKA with patellar resurfacing (group I) and without patellar resurfacing (group II). The onlay surgical technique was used for patellar preparation, and a cemented all-polyethylene dome-shaped patellar button with three pegs was used for implantation. The Knee Society Score (KSS), Knee Functional Score (KFS) and visual analogue score were used for clinical assessment.

Results:
All outcomes were assessed after 1 year of follow-up in both the groups. There was a statistically significant difference between the group I and group II knees in the mean pain score (P < 0.001), 47.8 and 41.2, respectively, in the visual analogue score (P = 0.002), 0.76 and 1.56, respectively, and the mean KSS (P < 0.001), 90.28 and 84.16, respectively. However, there was no difference in the mean pre-operative and post-operative KFS between the two groups (P = 1.000), 45.00 (standard deviation [SD] ± 12.22) and 88.72 (SD ± 10.33), respectively. There was no statistical difference in the complication rates between the two groups.

Conclusions:
There is a significant improvement in anterior knee pain after patella resurfacing resulting in higher patient satisfaction.
What are the Impacts on Community Wellbeing of Social Relations in Conservation Projects?
Authors: Barclay Kate , Fabinyi Michael , Song Annie Young , Ota Yoshi , Vandenberg Jessica , McClean Nick 
Published: July 2024

Abstract
Organisations working on conservation and community-based natural resource management (CBNRM) projects with communities have sometimes damaged the wellbeing of those communities. The social and political dynamics between organisations funding or implementing projects and the communities in which they work might be a factor causing this damage. This review paper explores the literature for evidence of and methods for evaluating impacts on community wellbeing from social relations in conservation and natural resource management projects. We found 101 papers addressing social connections in the human wellbeing-conservation nexus, acknowledging the damage done by colonising project relations and detailing proposals for or examples of more equitable relationality, and also evaluations of social equity in conservation/CBNRM work. However, we found few explicit evaluations of how the social, economic, and political relations of projects impact the wellbeing of participating communities. We call on researchers to address this gap, especially those working in evaluating project outcomes. To advance this agenda, we present literature that sheds light on what more equitable project relations look like, and how project relationality might be evaluated. We finish with ideas for how organisations can diagnose internal relationality problems likely to affect project outcomes, and how to transform those.
A predictive modeling approach for Taiwanese diagnosis-related groups medical costs: A focus on laparoscopic appendectomy
Authors: Wu Jia-Min , Tung Ann-Chen , Tsou Shung-Sheng 
Published: July 2024

AbstractBackground:In the Taiwanese diagnosis-related groups (Tw-DRGs) system, effective management of medical resources is vital to ensure the sustainability of hospital operations.Objectives:The aim is to create a predictive model to estimate the medical costs linked to a specific Tw-DRGs item, utilizing laparoscopic appendectomy without complications or comorbidities (DRG16701) as a representative case.Methods:We employed a dataset comprising 248 surgical cases performed at a regional teaching hospital between January 2017 and December 2019. These cases were classified based on the difference between the Tw-DRGs payment standard and actual medical costs. Two experiments were conducted: one without feature selection and one with feature selection. We utilized random forest (RF) and principal component analysis in each experiment. Each experiment applied the following four predictive models: decision tree, RF, logistic regression, and backpropagation neural network. The models were evaluated by measuring the accuracy, F1-score, and area under the receiver operating characteristic curve (AUROC).Results:The RF model demonstrated satisfactory performance, achieving an accuracy and F1-score of 0.920 on the testing set, with an AUROC ranging from 0.92 to 0.95. Feature selection methods enhanced model performance, particularly for the RF model. Critical features included premeal glucose levels, age, body mass index, weight, potassium, activated partial thromboplastin time, C-reactive protein level, and height.Conclusion:On average, each laparoscopic appendectomy case resulted in a deficit of NTD 3173.6. Cost prediction proved feasible using routine blood test data obtained upon admission or before surgery. The RF model and feature selection emerged as the most suitable predictive model for this specific purpose.
Effect of Modified Slow Breathing Exercise on Perceived Stress and Basal Cardiovascular Parameters
Authors: Naik G. Sunil , Gaur G.S. , Pal G.K. 
Published: July 2024

Context:
Different types of breathing exercises have varied effects on cardiovascular parameters and the stress levels in an individual.

Aim:
The aim of this study was to assess the effect of a modified form of isolated alternate nostril, slow breathing exercise on perceived stress, and cardiovascular parameters in young, male volunteers.

Settings and Design:
This was a randomized control study carried out at Advanced Centre for Yoga Therapy Education and Research, Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry in 2014.

Subjects and Methods:
Hundred healthy male volunteers were randomized into control group, n = 50 and slow breathing group (study), n = 50. Slow breathing exercise training was given to study group for 30 min a day, 5 times/week for 12 weeks, under the supervision of certified yoga trainers. Perceived Stress Scale (PSS) using Cohen's questionnaire, anthropometric parameters such as body mass index (BMI), waist-hip ratio (WHR), and cardiovascular parameters such as heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded at baseline and after 12 weeks. The control group did not receive any intervention. Slow breathing exercise training was provided for the study group. During the study period, one volunteer opted out of the study group due to personal reasons.

Results:
HR, SBP, DBP, and PSS decreased significantly (P < 0.05) in the study group following 12 weeks slow breathing exercise training, while no significant change (P > 0.05) was observed in BMI and WHR. There was no significant change in the control group.

Conclusion:
Twelve weeks of modified slow breathing exercise reduced perceived stress and improved the cardiovascular parameters. The above results indicate that our modified slow breathing exercise is effective in reducing stress and improving the cardiovascular parameters.
Effects of Maharishi Yoga Asanas on Mood States, Happiness, and Experiences during Meditation
Authors: Gobec Sonja , Travis Frederick 
Published: July 2024

Context/Background:
Many studies showed positive effects of Yoga Asanas. There is no study on Maharishi Yoga Asanas yet. This research replicated and expanded observed improvements on the profile of mood states (POMS) as a result of 2-week Maharishi Yoga Asanas course. Thirteen college students taking part in a 4-week course on Maharishi Yoga Asanas were matched with 13 students taking other courses at the university.

Aims and Objective:
The main objective of the study was to assess the effects of Maharishi Yoga Asanas on mood states, degree of happiness, and experiences in Transcendental Meditation (TM) practice.

Methods:
All students were given two psychological tests and additional question before and after their 4-week course: POMS, Meditation Depth Questionnaire, and question about the degree of happiness.

Results:
Repeated measure MANOVA showed the 4-week Maharishi Yoga Asanas course resulted in significant increase in happiness during the day and significant improvements in (1) sense of personal self, (2) transpersonal qualities, and (3) transpersonal self during their TM practice.

Conclusion:
This research shows that Maharishi Yoga Asanas affect more than body and mind. Rather they influence much deeper levels of one's subjectivity including one's transpersonal self.
Effects of Multimodal Mandala Yoga on Social and Emotional Skills for Youth with Autism Spectrum Disorder
Authors: Litchke Lyn Gorbett , Liu Ting , Castro Stephanie 
Published: July 2024

Context:
Youth with autism spectrum disorder (ASD) demonstrates impairment in the ability to socially and emotionally relate to others that can limit participation in groups, interaction with peers, and building successful life relationships.

Aims:
The aim of this exploratory study was to examine the effects of a novel multimodal Mandala yoga program on social and emotional skills for youth with ASD.

Subjects and Methods:
Five males with ASD attended 1 h yoga sessions, twice a week for 4 weeks. Multimodal Mandala yoga comprised 26 circular partner/group poses, color and tracing sheets, rhythmic chanting, yoga cards, and games. Treatment and Research Institute for ASD Social Skills Assessment (TSSA) scores were collected before and after the eight yoga sessions. The Modified Facial Mood Scale (MFMS) was used to observe mood changes before and after each yoga class. Paired sample t-tests were conducted on TSSA and MFMS scores to compare social and emotional differences post the 4-week camp. Narrative field notes were documented after each of the eight yoga sessions.

Results:
A significant improvement from pre- to post-test was found in overall TSSA (t(4) = −5.744, P = 0.005) and on respondent to initiation (t(4) = −3.726, P = 0.020), initiating interaction (t(4) = −8.5, P = 0.039), and affective understanding and perspective taking subscales (t(4) = −5.171 P = 0.007). Youth's MFMS scores increased from 80% to 100% at the end of eight yoga sessions demonstrating a pleasant or positive mood. Thematic analysis of the narrative notes identified three key factors associated with the yoga experience: (a) enhanced mood and emotional expression, (b) increased empathy toward others, and (c) improved teamwork skills.

Conclusion:
This multimodal Mandala yoga training has implication for developing positive social and emotional skills for youth with ASD.
Purple Urine Bag Syndrome: Unveiling the Puzzling Discoloration
Authors: Verma Akshay Bhanu , Kori Pradeep Kumar , Jain Neeraj 
Published: July 2024

Abstract
Purple urine bag syndrome (PUBS) is a rare entity first described by Barlow and Dickinson in 1978 characterized by purple discoloration of urine in long-term debilitated patients with chronic indwelling urinary catheters. This syndrome is a result of a breakdown of indole into indoxyl sulfate and further metabolic degradation into indigo by the bacteria in the urinary tract resulting in the characteristic purple hue of the urine. We describe the case of a 60-year-old male, bedridden due to traumatic paraplegia, presenting to us with lower abdominal pain and purple discoloration of urine due to Proteus mirabilis.
Evaluation of flexural strength and microhardness in Vaccinium macrocarpon (cranberry)-added self-cure polymethyl methacrylate dental resin: An in vitro study
Authors: Anitha K. V. , Krishnan Rajkumar 
Published: July 2024

Aim:
Occurrence of denture stomatitis and prosthesis breakage are common problems faced by elderly people wearing removable dentures. To overcome this, several attempts are made to improve the denture material by addition of antimicrobials without compromising original properties. The aim of the study was to evaluate flexural strength and microhardness of self-cured polymethyl methacrylate (PMMA) denture base resin after addition of Vaccinium macrocarpon (commonly called as cranberry), extract as antimicrobial, at varying proportions.

Study Setting and Design:
Experimental in vitro study.

Materials and Methods:
Frozen cranberry fruits were subjected to extraction process in the presence of aqueous solvents. Lyophilized extract was added in proportions of 0, 0.5, 1.0, 1.5, and 2.0 dry wt/wt % into polymer of self-cure PMMA denture base resin. Based on cranberry inclusion, the study comprised one control (0%) and four test groups (0.5%–2%) with total of 100 samples. A three-point bending test for flexural strength was done for fifty study samples (n = 10). Surface of fractured samples was analyzed using a scanning electron microscope (SEM). Microhardness was determined using Vickers hardness test.

Statistical Analysis Used:
One-way statistical ANOVA test was done to find the difference between groups, followed by Tukey’s post hoc test for multiple pairwise comparison.

Results:
Flexural strength ranged from 66.80 to 69.28 MPa, and a statistically insignificant difference was observed between groups (P > 0.05). SEM evaluation showed uniformly dispersed strands of cranberry extract in PMMA matrix. With higher concentration, less voids were seen. Vickers microhardness value significantly decreased from 15.96 in the control group to 14.57 with 2% cranberry addition (P < 0.05).

Conclusion:
Incorporation of cranberry extract into self-cure PMMA denture base resin, up to 2 dry wt %, did not decline the flexural strength. However, there was a significant decrease in Vickers microhardness values when compared against the control group (0% cranberry inclusion).
Assessment of occlusion changes during laboratory phase of relining: An in vitro study
Authors: Verma Ayush , Prasad D. Krishna , Hegde Chethan 
Published: July 2024

Aim:
Assessment of occlusion changes during laboratory phase of relining is essential to evaluate the occlusal discrepancies that could get incorporated in the denture with the use of different relining materials. Since the long term stability and functional success of the denture is heavily influenced by occlusion, an In-vitro study to assess these changes after relining is warranted. The aim of the study is to evaluate the changes in occlusion during laboratory phase of relining procedure.

Settings and Design:
This is an in vitro study with a total of 30 specimen.

Materials and Methodology:
A total of 30 maxillary standardized dentures were fabricated after mounting on a semi adjustable articulator. These samples will be divided into three groups based on the relining material used (Autopolymerizing resin, Heat-cure resin, Tissue conditioner). The vertical dimension, Centric contact points and eccentric contact points were measured before and after relining.

Statistical Analysis Used:
The variables were tested to see if they had a normal distribution using the Shapiro-Wilk test. Parametric distribution was seen for ECP leading to further comparison using one way analysis of variance (ANOVA). Non-parametric distribution was found while testing the VD, CCP leading to adoption of Kruskal-wallis test for comparison of groups. Dunn Bonferroni test was done for VD since results were significant.

Results:
The results of this in-vitro study showed statistically significant difference with respect to change in vertical dimension in all groups pre and post relining (P = 0.005). The centric contact points showed lesser variation in position when comparing the pre to the post relining phase with the use of autopolymerising resins, whereas heat cure resins and tissue conditioners showed statistically significant difference in the centric point contacts post relining. No statistically significant changes were seen in eccentric occlusion post relining in all groups. Tissue conditioners showed minimum mean changes in eccentric contacts.

Conclusion:
Within the limitations of this study, the use of autopolymerising resins depicted the most stable results with respect to occlusion, for relining of dentures.
Comparative evaluation of osseodensification drilling versus conventional drilling technique on dental implant stability: A systematic review
Authors: Banerjee Saurav , Dasgupta Dolanchanpa , Parasrampuria Nikita , Pal Dipankar , Gandhi Udey Vir 
Published: July 2024

Aim:
The present systematic review compares the stability, crestal bone levels and efficacy of osseodensification (OD) drilling techniques for dental implant placement to traditional drilling methods.

Settings and Design:
The Cochrane online library, PubMed, Scopus, and other well-known online resources are used in the research. Using a systematic review design, the current study examines published qualitative studies with an emphasis on analysis.

Materials and Methods:
Using precise keywords, a thorough search of pertinent databases was carried out in accordance with PRISMA standards. Studies testing dental implant stability, crestal bone levels and clinical results using both OD and traditional procedures were covered by the inclusion criteria.

Statistical Analysis Used:
The risk of bias and quality of included studies was assessed using the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk of Bias tool for randomized controlled trials.

Results:
A total of 170 patients and 334 implants from Egypt, India, and Brazil were included in eight papers that made up the systematic review. In several clinical situations, osseodensification outperformed standard drilling in terms of implant durability, bone development, and torque data. Statistical analysis presented the lowest risks, while blinded outcome assessment, allocation concealment, random sequence generation, incomplete outcome data and experimental technique revealed higher risks. Bias assessment found various risks across different components.

Conclusion:
The thorough examination of eight papers demonstrates that osseodensification is a technique with great promise in the field of dental implants. It exhibits superior torque values, bone development, and stability when compared to traditional drilling. The overall results highlight the potential of osseodensification to improve clinical outcomes and advance the science of dental implantology, even in the face of variances in bias concerns.