bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of adverse cardiovascular events with gabapentin and pregabalin among patients with fibromyalgia
Authors: Pan Yiheng , Blankfield Robert P. , Kaelber David C. , Xu Rong 
Published: July 2024

Objective
Fibromyalgia, a chronic pain disorder, impacts approximately 2% of adults in the US. Gabapentin and pregabalin are common treatments to manage fibromyalgia-related pain. Our recent study showed the risk of adverse cardiovascular events increased in diabetic neuropathy patients who were prescribed gabapentin or pregabalin. Here, we investigated whether the prescription of gabapentin or pregabalin has similar cardiovascular risk in patients with fibromyalgia.

Methods
This retrospective cohort study leveraged electronic health records from 64 US healthcare organizations with 112 million patients. The study population included 105,602 patients first diagnosed with fibromyalgia and followed by a prescription of gabapentin, pregabalin, or other FDA-approved drugs for treating fibromyalgia from 2010 to 2019. Outcomes were deep venous thrombosis (DVT), myocardial infarcts (MI), peripheral vascular disease (PVD), strokes, heart failure, and pulmonary embolism (PE). In propensity-score-matched cohorts, 1-year and 5-year hazard ratios (HRs) were computed with their respective 95% confidence intervals (CIs). Additionally, we conducted sensitivity analyses on the subpopulations without other possible indications.

Results
For 5-year follow-up, gabapentin increased the risk of PVD (HR = 1.46, 95% CI = 1.17–1.80), MI (HR = 1.31, 95% CI = 1.03–1.66), heart failure (HR = 1.27, 95% CI = 1.10–1.48), DVT (HR = 1.80, 95% CI = 1.33–2.44), and PE (HR = 2.23, 95% CI = 1.62–3.07). Pregabalin increased the risk of DVT (HR = 1.49, 95% CI = 1.01–2.20), and PE (HR = 2.24, 95% CI = 1.43–3.50). For 1-year follow-up, gabapentin increased the risk of PVD (HR = 1.32, 95% CI = 1.11–1.57), DVT (HR = 1.35, 95% CI = 1.09–1.68), and PE (HR = 1.36, 95% CI = 1.17–1.57). Pregabalin increased the risk of PVD (HR = 1.32, 95% CI = 1.06–1.63) and PE (HR = 1.25, 95% CI = 1.03–1.52). Sensitivity analyses showed similar trends.

Conclusion
In fibromyalgia patients, the prescription of gabapentin and pregabalin moderately increased the risk of several adverse cardiovascular events. This risk, together with benefits and other adverse reactions, should be considered when prescribing these medications for fibromyalgia patients.
Produção associada de amilases e celulases através de fermentação submersa
Authors: Lopes Samuel Teixeira , Bender Leticia Eduarda , Berwian Gabrielle Fusiger , Colla Luciane Maria 
Published: July 2024

O estudo objetiva estudar a otimização da produção homemade associada de enzimas amilolíticas e celulolíticas por fermentação submersa. A produção de enzimas foi realizada utilizando bagaço de cana-de-açúcar e farinha de triticale como substratos do meio fermentativo, utilizando bactérias isoladas de resíduos agroindustriais. Os extratos enzimáticos foram avaliados quanto à atividade amilolítica e celulolítica. As variáveis significativas (p<0,05) sobre a produção amilolítica foram a bactéria e a fonte de nitrogênio, para produção celulolítica foram a bactéria, concentração e fonte de nitrogênio. Ademais, as atividades enzimáticas máximas foram obtidas no tempo de 120 h para ambas as enzimas estudadas. Neste sentido, a fermentação poderia ser encerrada em 120 h devido a elevada produção das enzimas de interesse (6,02 U/mL para atividade amilolítica e 5,52 U/mL para a atividade celulolítica). Uma segunda fermentação submersa foi realizada, fixando as variáveis que não apresentaram significância segundo o delineamento Plackett-Burman e avaliando duas concentrações de sulfato de amônio (0,25 e 0,50%). A partir disso, foi possível determinar as condições otimizadas para a produção homemade e associada de amilases e celulases bacterianas, sendo a Bactéria B em meio de cultivo com suplementação de 0,25% de sulfato de amônio como fonte de nitrogênio.
Vida Filosófica e a busca pela verdade - um diálogo entre Heidegger e Foucault
Authors: Nunes da Costa Marta Rios Alves 
Published: July 2024

Resumo: Neste artigo, a partir de um diálogo com Heidegger e Foucault, mediado pontualmente por um retorno aos Antigos em particular a Sócrates, procuro retomar o problema e questão da Vida filosófica, na sua relação com a busca pela verdade. O artigo tem dois momentos: no primeiro, explorei uma leitura de Filosofia enquanto caminho, e, num segundo momento, defendi que este caminho articula a dimensão ética e a dimensão política, através de uma experiência (necessária) específica de parresia pessoal. Defendo que a verdade enquanto desvelamento exige sempre a transformação do indivíduo em sujeito, isto é, em pessoa moral, o que requer, nesse processo, o compromisso com a coerência de si, através de uma prática de dizer-a-verdade.
Palavras-chave: Foucault; Heidegger; Parresia; Verdade
Philosophical Life and the search for truth - a dialogue between Heidegger and Foucault
Abstract: In this article, based on a dialogue with Heidegger and Foucault, punctually mediated by a return to the Ancients and in particular to Socrates, I try to resume the problem and question of philosophical Life, in its relationship with the search for truth. The article has two moments: in the first, I explored a reading of Philosophy as a path, and, in a second moment, I argued that this path articulates the ethical dimension and the political dimension, through a specific (necessary) experience of personal parrhesia. I argue that truth as unveiling always requires the transformation of the individual into a subject, that is, into a moral person, which requires, in this process, a commitment to self-coherence, through a practice of telling the truth.
Key-words: Foucault; Heidegger; Parrhesia; Truth
La vie philosophique et la recherche de la vérité - un dialogue entre Heidegger et Foucault
Resumé: Dans cet article, à partir d'un dialogue avec Heidegger et Foucault, médiatisé ponctuellement par un retour aux Anciens et en particulier à Socrate, j'essaie de reprendre le problème et la question de la Vie philosophique, dans son rapport à la recherche de la vérité. L'article comporte deux moments : dans le premier, j'ai exploré une lecture de la Philosophie comme voie, et, dans un second temps, j'ai soutenu que cette voie articule la dimension éthique et la dimension politique, à travers une expérience spécifique (nécessaire) de parrhésie. Je soutiens que la vérité en tant que dévoilement nécessite toujours la transformation de l'individu en sujet, c'est-à-dire en personne morale, ce qui nécessite, dans ce processus, un engagement à la cohérence de soi, à travers une pratique de dire la vérité.
Mots-clés: Foucault; Heidegger; Parrhesia; Verité

Data de registro: 06/09/2022
Data de aceite: 18/10/2023
Occurrence characteristics of ionospheric scintillations in the civilian GPS signals (L1, L2, and L5) through a dedicated scintillation monitoring receiver at a low-latitude location in India during the 25th solar cycle
Authors: Vankadara Ram Kumar , Seif Aramesh , Panda Sampad Kumar 
Published: July 2024

Abstract
The ionospheric post-sunset irregularities are responsible for the discrepancies in the received global navigation satellite system (GNSS) signals to fluctuate the phase and amplitude resulting in scintillations in the respective components. Ionospheric scintillations reduce the signal quality and alter the signal reception time inducing position errors which is not preferable for the precise position applications. The level of ionospheric amplitude scintillation, quantified by the amplitude scintillation index (S4), is analyzed during the year 2022, which accentuates the ascending phase of solar cycle 25. For this, we analyzed scintillation intensity and occurrence percentage at a low latitude Indian location in India by employing all the available frequencies of the global positioning system (GPS) constellation. The scintillation distribution for each month is also observed which reveals that the autumn equinox seasons has high scintillation occurrence compared to the vernal equinox seasons. The impact of the scintillation on the three civilian signals (L1, L2 and L5) of the GPS constellation is also observed in terms of the scintillation intensity distribution. The cross-correlation of the S4 index for these three signals reveals a strong correlation existing among them during strong scintillations whereas L2 and L5 signals portray a high correlation irrespective of signal intensities. In brief, the strong scintillation occurrence percentage is higher in the L5 signal compared to the L1 and L2 in contrast with weak scintillation, which is high in L1, followed by L2 and L5. Further, the analysis shows that the autumnal equinox has the highest percentage occurrence of strong scintillations (less than 10 % of the scintillation cases) compared to the vernal equinox whereas among solstice seasons June solstice presented the least scintillation occurrence at the location. The outcomes of this study instigate further analysis of scintillation occurrences from diverse GNSS frequencies covering diverse solar activity conditions for complementing the development of robust scintillation mitigation strategies across the low latitudes during the diverse scintillation conditions.
Multilateral evaluation of the effects of utilizing thorium oxide in the Bushehr VVER-1000 reactor
Authors: Lotfalian Mohammadreza , Athari Allaf Mitra , Mansouri Masoud 
Published: July 2024

Abstract
The use of thorium oxide in thermal reactors is currently being explored due to its promising outcomes. One primary concern is how to reduce the pollution of core components and nuclear waste. The inclusion of 232Th in the reactor leads to the production of 233U and decreases the formation of minor actinides. On the other hand, 238U increases the production of 239Pu, a toxic and strategically significant isotope, along with minor actinides. Therefore, the potential of thorium to reduce the production of 239Pu, one of the most harmful isotopes, can be assessed in the Bushehr VVER-1000 reactor. This study involved replacing some uranium in the Bushehr VVER-1000 reactor with 232Th. The research focused on examining the environmental impact of nuclear waste, including activity, chain reactions, and isotope levels, over a two-year period. The impact of the new fuel substitution was evaluated in the Bushehr reactor, which has a power of 3,000 MWth, in three scenarios: thorium addition to 1.6 % enriched assemblies, thorium addition to 2.4 % enriched assemblies, and thorium addition to 3.6 % enriched assemblies. These changes were analyzed in terms of nuclear waste contamination, plutonium production, fuel burn-up, and conversion ratio, and compared to the reactor using UO2 fuel. The simulation was conducted using the MCNPX 2.6.0 computational code and heterogeneous geometry. The results indicate that nuclear waste pollution decreased when thorium was added to the 1.6 % and 2.4 % enriched assemblies, but increased when added to the 3.6 % assemblies. Additionally, fuel burn-up increased with the addition of thorium in the 1.6 % and 2.4 % assemblies, but decreased in the 3.6 % assemblies. However, the conversion ratio increased in all cases. The fuel temperature coefficient (FTC), moderator temperature coefficient (MTC), and void coefficient (VC) were calculated and evaluated.
ON A METHOD OF CONTROLLING THE HEATER BY USING NEURAL NETWORKS
Authors: АБДУРАКИПОВ С.С. , БУТАКОВ Е.Б. 
Published: July 2024

Исследуется возможность применения нейронной сети долгой краткосрочной памяти (Long short-term memory, LSTM) для моделирования работы ПИД-регулятора. Реализован программный ПИД-регулятор для управления нагревателем с датчиком температуры на микроконтроллере Arduino, и разработана LSTM-модель, обученная на данных регулятора. Показано, что модель нейронной сети хорошо воспроизводит работу регулятора и может его полностью заменить при наличии многократно большего, но достаточного времени обработки данных. Продемонстрирована возможность использования данной модели в качестве детектора аномальной работы ПИД-регулятора.
The paper studies the possibility of using a long short-term memory (LSTM) neural network to simulate the operation of a PID controller. A PID regulator has been implemented to control a heater with a temperature sensor by using the Arduino framework. An LSTM model trained on the controller data has been developed. It is shown that the neural network model quite accurately reproduces the regulator operation and can completely replace it. In addition, the applicability of this model as a detector of abnormal operation of the PID controller is shown.
EVENT-DISCRETE TRAFFIC CONTROL MODELS
Authors: ШОРНИКОВ Ю.В. , ТИМОФЕЕВ К.А. 
Published: July 2024

Решается задача управления транспортным движением с помощью модельно-ориентированного метода. Для разработки математической модели предложен автоматный формализм. В строгом соответствии с условиями задачи определены состояния детерминированного конечного автомата (ДКА) и предикаты направленных переходов. Для реализации ДКА выполнен переход к диаграмме Харела (statechart) - унифицированному математическому и программному обеспечению современных мировых инструментальных средств моделирования. Решение поставленной задачи доказано конструктивно таблицей состояний с соответствующей динамикой и вычислительными экспериментами выбранного сценария в передовых отечественных и зарубежных инструментальных средах моделирования обозначенного класса событийных систем. Вычислительные эксперименты показали полное совпадение с конструктивным анализом.
The problem of traffic control is solved using a model-oriented method. To develop a mathematical model, an automaton formalism is proposed. In strict accordance with the problem conditions, the states of a deterministic finite automaton (DFA) and predicates of directed transitions are defined. To implement the DFA, a transition is made to the Harel diagram (statechart), which is a unified mathematical and software support for modern global modeling tools. The solution to the problem posed is proved constructively by a table of states with the corresponding dynamics and computational experiments of the selected scenario in advanced domestic and foreign instrumental environments for modeling the designated class of event systems. Computational experiments show complete agreement with constructive analysis.
EFFECT OF Fe— Co — Cr CONTENT AND MECHANICAL ACTIVATION ON COMBUSTION IN A Ni—Al—(Fe—Co—Cr) SYSTEM
Authors: КОЧЕТОВ Н.А. , БУСУРИНА М.Л. 
Published: July 2024

Проведено исследование влияния механической активации и количества связки Fe + Co + Cr на скорость и максимальную температуру горения, удлинение образцов в процессе горения, размер композитных частиц и выход смеси после активации, фазовый состав и морфологию продуктов синтеза в системе Ni—Al—(Fe—Co—Cr). Механоактивация смеси Ni + Al + x(Fe + Co + Cr) позволила реализовать горение образцов при комнатной температуре при содержании связки Fe + Co + Cr до 40 %. Активация смесей увеличила скорость и температуру горения, удлинение образцов продуктов и их пористость, уменьшила их прочность. Возрастание содержания связки Fe + Co + Cr в активированной смеси Ni + Al + x(Fe + Co + Cr) привело к увеличению выхода смеси после механоактивации, уменьшению размера композитных частиц и удлинению образцов продуктов синтеза. Зависимость скорости горения активированных смесей от содержания связки Fe + Co + Cr немонотонна, имеет максимум при содержании связки 10 %. Методом СВС синтезированы высокоэнтропийные сплавы — твердые растворы на основе интерметаллидов NiAl и Ni3Al.
The influence of mechanical activation and amount of Fe + Co + Cr binder on the combustion rate and maximum temperature, sample elongation during combustion, composite particle size and mixture yield after activation, phase composition and morphology of synthesis products in the Ni–Al–(Fe–Co–Cr) system was studied. Mechanical activation of the Ni + Al + x(Fe + Co + Cr) mixture allowed the samples to burn at room temperature with a Fe + Co + Cr binder content of up to 40%. Activation of the mixtures increased the combustion rate and temperature, sample elongation and porosity, and decreased their strength. An increase in the Fe + Co + Cr binder content in the activated Ni + Al + x(Fe + Co + Cr) mixture led to an increase in the mixture yield after mechanical activation, a decrease in the composite particle size and an elongation of the synthesis product samples. The dependence of the combustion rate of activated mixtures on the content of the Fe + Co + Cr binder is non-monotonic, and has a maximum at a binder content of 10%. High-entropy alloys – solid solutions based on intermetallic compounds NiAl and Ni3Al – were synthesized by the SHS method
DESCRIPTION OF PREMIXED TURBULENT COMBUSTION IN A CHANNEL WITH A STEP USING PARTIALLY STIRRED REACTOR MODELS
Authors: БАЛАБАНОВ Р.А. , ВЛАСЕНКО В.В. , НОЗДРАЧЕВ А.Ю. 
Published: July 2024

Рассматривается дозвуковое турбулентное горение предварительно перемешанной метановоздушной смеси в модельном канале с обратным уступом (P. Magre и др., ONERA, 1975–1989). В экспериментах воспроизведены базовые физические механизмы, характерные для процессов горения в газотурбинных установках. Дан краткий обзор предыдущих работ по численному моделированию этих экспериментов. Описаны новые результаты численного исследования режима стабилизированного горения в данной установке. Проведено сравнение нескольких подходов к описанию турбулентного горения из класса PaSR (partially stirred reactor — модели реактора частичного перемешивания) с квазиламинарным подходом. Представлена модель переменных турбулентных чисел Прандтля и Шмидта, и рассмотрено ее влияние на воспроизведение данного течения в расчете.
Subsonic turbulent combustion in a premixed methane—air mixture in a model channel with a backward step is considered (P. Magre et al., ONERA, 1975–1989). The main physical mechanisms characteristic of combustion in gas turbine combustors are reproduced in experiments. A brief overview of previous numerical simulations of these experiments is given. New results from a numerical study of the stabilized combustion regime in this combustor are described. Several partially stirred reactor (PaSR) models for describing turbulent combustion are compared with a quasi-laminar approach. A model of variable turbulent Prandtl and Schmidt numbers is presented, and its influence on the reproduction of this flow in calculations is considered.
SYNTHESIS OF DOUBLE PHOSPHATES IN A COMBUSTION WAVE
Authors: ВЕРЕЩАГИН А.Л. , МИНИН Е.Д. 
Published: July 2024

Изучался состав продуктов сгорания в воздухе при атмосферном давлении гипофосфита кальция Ca(H2PO2)2 c окислителями — нитратами либо нитритами натрия или калия. Синтез проводился с целью получить двойной фосфат состава Na(K)CaPO4. Готовились смеси порошков с нулевым кислородным балансом, для этого при необходимости вводили дополнительное количество нитрата аммония. Фазовый состав конденсированных продуктов сгорания исследовали методом рентгенофазового анализа. Смеси устойчиво горели при атмосферном давлении с выделением аэрозоля P4O10. Продукты сгорания представляли собой оплавленные частицы белого цвета размером до 1 мм. В конденсированных продуктах сгорания обнаружены двойные фосфаты NaCaPO4, Na2CaP2O7, K2CaP2O7, KCaPO4 и пирофосфаты кальция Ca2P2O7.
The composition of combustion products of calcium hypophosphite Ca(H2PO2)2 with sodium or potassium nitrates or nitrites as oxidizers in air at atmospheric pressure has been studied. Synthesis was carried out to obtain double phosphate of the composition Na(K)CaPO4. Mixtures of powders with zero oxygen balance were prepared using, if necessary, an additional amount of ammonium nitrate. The phase composition of condensed combustion products was studied by X-ray powder analysis. The mixtures burned stably at atmospheric pressure releasing P4O10 aerosol. The combustion products were melted white particles up to 1 mm in size. In condensed combustion products were found to contain the double phosphates NaCaPO4, Na2CaP2O7, K2CaP2O7, and KCaPO4 and calcium pyrophosphates Ca2P2O7.
The decline of outdoor activity among Gen-Z: A need for reviving street sports for community, art, and career development
Authors: Toth A. 
Published: July 2024

AbstractIn the digital age, outdoor activities dwindle, affecting the physical and social development of young people. The Venice Basketball League in Los Angeles, California stands out as a haven, blending sports, art, and community, inspiring careers, and transcending societal divides. Amidst challenges, it offers hope, reminding us of the vitality of authentic connections and the transformative power of street culture in shaping vibrant communities and professional careers. As society grapples with the challenges of digital connectivity, the revival of street sports offers a beacon of hope – a reminder of the organic spaces where connections are forged, creativity thrives, and individuals can express themselves authentically.
Optimizing athletes' mindsets: Application of Rational Emotive Behavior Therapy (REBT) in sport
Authors: Tóth Renátó , Resperger Viktória , Tóth László 
Published: July 2024

AbstractThis paper explores the integration of Rational Emotive Behavior Therapy (REBT) within sports psychology, aiming to enhance athletes' mental health and performance of athletes. Sports psychology, encompassing diverse approaches, prioritizes both the mental well-being and performance of athletes. REBT, a vital component of Cognitive Behavioral Therapy (CBT), revolves around an individual's beliefs influencing emotional, behavioral, and physiological reactions to events. It identifies and replaces irrational beliefs with rational alternatives, as depicted in the GABCDE model, emphasizing the impact of beliefs on reactions to triggering events. Previous research highlighted the detrimental impact of irrational beliefs on athletes' mental well-being, identifying these beliefs as a significant risk factor for the emergence of mental disorders, which in turn lead to compromised performance. The integration of REBT into sports psychology shows promise in reducing anxiety, perfectionism, and irrational beliefs among athletes. Its flexibility allows for swift and powerful interventions, either individually or in group settings, fostering mental resilience and enhancing performance. Sports psychologists and coaches play pivotal roles in recognizing and addressing athletes' irrational beliefs, fostering a rational mindset conducive to stable and positive performance. Integrating REBT into training and performance enhancement offers athletes a stable mental foundation, improving self-confidence and stress management, thereby optimizing sports performance. Overall, the integration of REBT into sports psychology offers a promising avenue to bolster athletes' mental fortitude, optimize performance, and foster a balanced mental landscape, facilitating the attainment of their athletic goals.
Anthropocene Fantasy and Infrastructures of Exploitation
Authors: Carroll Siobhan Maria , Larkin Edward 
Published: July 2024

AbstractThis essay traces the emergence of Anthropocene fantasy through an analysis of three multivolume series—George R. R. Martin's A Song of Ice and Fire, Robin Hobb's Realm of the Elderlings, and N. K. Jemisin's The Broken Earth. Each of these series repurposes the conventions of epic fantasy to analyze the ideological underpinnings of anthropogenic crisis. Among the most important tropes revised are fantasy infrastructures, which, in Anthropocene fantasy, frequently manifest a problematic division between the human and the nonhuman. Consequently, characters’ responses to these infrastructures often reflect these novels’ ecological politics. The surrender of agency associated with the abandonment of ancient infrastructures further indicates Anthropocene fantasy's interest in reimagining the individualistic mode of human agency that drives so many novel plotlines, fantasy and realist alike. Anthropocene fantasy's revision of its own problematic genre infrastructures thus has implications not only for the epic fantasy but for the novel form more broadly.