bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral α‐Fluoro Carbanions.
Authors: Shen Xiao , Miao Wenjun , Ni Chuanfa , Hu Jinbo 
Published: July 2014

AbstractThe reaction proceeds with excellent stereocontrol at the chiral fluorinated carbon center, which is attributed to a dynamic kinetic resolution of the chiral α‐fluoro carbanions.
ChemInform Abstract: Reactions of Propargylic Bromides with Sodium Sulfinates.
Authors: Chang Meng‐Yang , Wu Ming‐Hao 
Published: July 2014

AbstractThe reaction of propargylic bromides with sodium arylsulfinates in the presence of Pd‐C and Bu4NF is described to give 2,3‐bissulfonylpropenes (III) or (V) in good yields.
ChemInform Abstract: Palladium(II) Complexes Bearing 2‐(1H‐Imidazol/oxazol‐2‐yl)‐pyridines: Synthesis, Structures and Ligand Effects in Suzuki—Miyaura Cross‐Coupling.
Authors: Eseola Abiodun Omokehinde , Geibig Daniel , Goerls Helmar , Sun Wen‐Hua , Hao Xiang , Woods Joseph Anthony Orighomisan , Plass Winfried 
Published: July 2014

AbstractA series of hemilabile 2‐(imidazol‐2‐yl)pyridine and 2‐(oxazol‐2‐yl)pyridine palladium ligands are synthesized, characterized, and their catalytic properties in high‐temperature Suzuki—Miyaura cross‐coupling reactions are investigated.
ChemInform Abstract: The Photoredox‐Catalyzed Meerwein Addition Reaction: Intermolecular Amino‐Arylation of Alkenes.
Authors: Prasad Hari Durga , Hering Thea , Koenig Burkhard 
Published: July 2014

AbstractA variety of amides are efficiently accessible under mild conditions by intermolecular amino‐arylation.
ChemInform Abstract: Synthesis and Characterization of Schiff Base Complex of Pd(II) Supported on Superparamagnetic Fe3O4@SiO2 Nanoparticles and Its Application as an Efficient Copper‐ and Phosphine Ligand‐Free Recyclable Catalyst for Sonogashira—Hagihara Coupling Reactions.
Authors: Esmaeilpour Mohsen , Sardarian Ali Reza , Javidi Jaber 
Published: July 2014

AbstractThe heterogeneous catalyst is easily removed by means of an external magnet and reused six times without significant loss of activity.
ChemInform Abstract: A Novel 1,2,4‐Triazine‐Functionalized Polystyrene Resin‐Supported Pd(II) Complex: A Copper‐ and Solvent‐Free Highly Efficient Catalyst for Sonogashira Coupling Reactions.
Authors: Bakherad Mohammad , Bahramian Bahram , Jajarmi Saeideh 
Published: July 2014

AbstractThe synthesis and characterisation of the heterogeneous catalyst is described.
ChemInform Abstract: Synthesis of Substituted Naphthalenes from α‐Substituted Ketones and 1,2‐Bis(halomethyl)benzenes Including a Rearrangement Aromatization of Benzo[c]oxepine.
Authors: Wang Jungang , Xiang Jiachen , Wang Miao , Guan Jie , Wu Anxin 
Published: July 2014

AbstractA facile metal‐catalyst‐free protocol allows the synthesis of cyano‐, sulfonyl‐, and phosphoryl‐substituted naphthalene derivatives.
ChemInform Abstract: Synthesis, Antibacterial, and Antifungal Activities of Imidazo[2,1‐c][1,2,4]triazoles and 1,2,4‐Triazolo[4,3‐a]pyrimidinones.
Authors: Aouali Monia , Allouche Fatma , Zouari Imen , Mhalla Dhekra , Trigui Mohamed , Chabchoub Fakher 
Published: July 2014

AbstractCompound (IIIc) is found to exhibit strong antibacterial and moderate antifungal activities.
ChemInform Abstract: Discovery of 5′′‐Chloro‐N‐ [(5,6‐dimethoxypyridin‐2‐yl)methyl] ‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia.
Authors: Roecker Anthony J. , et al. et al. 
Published: July 2014

AbstractThe development of title compound (I), one of the most potent and selective orexin 2 antagonists (2‐SORA) reported to date, is described including SAR study.
ChemInform Abstract: One‐Pot Synthesis of Nuevamine Aza‐Analogues by Combined Use of an Oxidative Ugi Type Reaction and Aza‐Diels—Alder Cycloaddition.
Authors: Islas‐Jacome Alejandro , Gutierrez‐Carrillo Atilano , Garcia‐Garibay Miguel A. , Gonzalez‐Zamora Eduardo 
Published: July 2014

AbstractThe convenient one‐pot sequence for the synthesis of the title species includes IBX‐mediated oxidation of amine (I) followed by isonitrile α‐addition, aza‐Diels—Alder cycloaddition, dehydration, and decarboxylation.
ChemInform Abstract: 6‐Carbohydrazonamidepurines: Convenient Precursors for 4,8‐Disubstituted Pyrimido[5,4‐d]pyrimidines.
Authors: Rocha Ashly , Bacelar Ana H. , Fernandes Joana , Proenca M. Fernanda , Carvalho M. Alice 
Published: July 2014

AbstractThe precursors (III) mentioned in the title are prepared from 6‐imidatopurines with hydrazides.
ChemInform Abstract: 2,6‐Difunctionalization of N‐Substituted Dithienothiazines via Dilithiation.
Authors: Dostert Catherine , Czajkowski Daniel , Mueller Thomas J. J. 
Published: July 2014

AbstractThe regioselective 2‐mono‐ and 2,6‐difunctionalization of dithienothiazines is accomplished via lithiation followed by electrophilic trapping.
ChemInform Abstract: Rhenium‐Mediated Dehydrogenative Silylation and Highly Regioselective Hydrosilylation of Nitrile Substituted Olefins.
Authors: Dong Hailin , Jiang Yanfeng , Berke Heinz 
Published: July 2014

AbstractThe rhenium‐catalyzed hydrosilylation of substituted olefins and acrylonitriles affords α‐addition products with high regioselectivity.
ChemInform Abstract: Preparation of Silyl Polyenol Ethers by Carbonyl Olefination of Silyl Esters.
Authors: Takeda Takeshi , Fukada Tatsuya , Tsubouchi Akira 
Published: July 2014

AbstractThe reagent Ti(Cp)2(P(O‐Et)3)2 is prepared in situ from Cp2TiCl2 and P(O‐Et)3.
ChemInform Abstract: Non‐Pyrolytic, Large‐Scale Synthesis of Trichalcogenasumanene: A Two‐Step Approach.
Authors: Li Xuexiang , Zhu Yongtao , Shao Jiafeng , Wang Baolin , Zhang Shangxi , Shao Yongliang , Jin Xiaojie , Yao Xiaojun , Fang Ran , Shao Xiangfeng 
Published: July 2014

AbstractA high‐yielding multigram‐scale synthesis of trichalcogenasumanenes (III) and (V) from triphenylene (I) using a non‐pyrolytic cyclization and solventless ring‐contraction conditions is presented.
ChemInform Abstract: Limonoids with an Oxygen Bridge Between C(1) and C(29) from the Seeds of a Krishna Mangrove, Xylocarpus granatum.
Authors: Li Min‐Yi , Xiao Qiang , Satyanandamurty Tirumani , Wu Jun 
Published: July 2014

AbstractTen limonoids (I)‐(VI), named granatumins L‐U are isolated from the seeds of an Indian mangrove, Xylocarpus granatum.
ChemInform Abstract: Formal Synthesis of (.+‐.)‐Cladoniamide G.
Authors: Ngernmeesri Paiboon , Soonkit Sarochar , Konkhum Anothai , Kongkathip Boonsong 
Published: July 2014

AbstractA new synthesis of the bisindole precursor (I) from 3‐methoxyindole by Suzuki‐Miyaura coupling is presented.
ChemInform Abstract: A Facile Chiral Pool Synthesis of 9‐epi‐Decarestrictine‐D (I), Decarestrictine‐D (II) and O (III).
Authors: Vamshikrishna Kuchena , Srinu Garlapati , Srihari Pabbaraja 
Published: July 2014

AbstractThe title compounds are synthesized from L‐diethyl tartrate.
ChemInform Abstract: PSiP‐Pincer Type Palladium‐Catalyzed Dehydrogenative Borylation of Alkenes and 1,3‐Dienes
Authors: Kirai Naohiro , Iguchi Shoichiro , Ito Tatsuyoshi , Takaya Jun , Iwasawa Nobuharu 
Published: July 2014

AbstractReview: [42 refs.
ChemInform Abstract: 1,2‐Bis(ferrocenyl)dipnictenes: Bimetallic Systems with a Pn=Pn Heavy π‐Spacer (Pn: P, Sb, and Bi)
Authors: Sakagami Michiyasu , Sasamori Takahiro , Sakai Heisuke , Furukawa Yukio , Tokitoh Norihiro 
Published: July 2014

AbstractReview: [29 refs.
ChemInform Abstract: Valorization of Agroindustrial Solid Residues and Residues from Biofuel Production Chains by Thermochemical Conversion: a Review, Citing Brazil as a Case Study
Authors: Virmond E. , Rocha J. D. , Moreira R. F. P. M. , Jose H. J. 
Published: July 2014

AbstractReview: 225 refs.
Localization and characterization of val‐opsin isoform‐expressing cells in the brain of adult zebrafish
Authors: Hang Chong Yee , Kitahashi Takashi , Parhar Ishwar S. 
Published: July 2014

ABSTRACTIn addition to vision, light information is used to regulate a range of animal physiology. Such nonimage‐forming functions of light are mediated by nonvisual photoreceptors expressed in distinct neurons in the retina and the brain in most vertebrates. A nonvisual photoreceptor vertebrate ancient long opsin (VAL‐opsin) possesses two functional isoforms in the zebrafish, encoded by valopa and valopb, which has received little attention. To delineate the neurochemical identities of valop cells and to test for colocalization of the valop isoforms, we used in situ hybridization to characterize the expression of the valop genes along with that of neurotransmitters and a neuropeptide known to be present at the sites of valop expression. Double labeling showed that the thalamic valop population coexpresses valopa and valopb. All the thalamic valop cells overlapped with a GABAergic cell mass that continues from the anterior nucleus to the intercalated thalamic nucleus. A novel valopa cell population found in the superior raphe was serotonergic in nature. A valopb cell population in the Edinger‐Westphal nucleus was identified as containing thyrotropin‐releasing hormone. Valopb cells localized in the hindbrain intermediate reticular formation were noncholinergic in nature (nonmotorneurons). Thus, the presence of valop cell populations in different brain regions with coexpression of neurotransmitters and neuropeptides and the colocalization of valop isoforms in the thalamic cell population indicate regulatory and functional complexity of VAL‐opsin in the brain of the zebrafish. J. Comp. Neurol. 522:3847–3860, 2014. © 2014 Wiley Periodicals, Inc.
Dynamics of nascent and active zone ultrastructure as synapses enlarge during long‐term potentiation in mature hippocampus
Authors: Bell Maria Elizabeth , Bourne Jennifer N. , Chirillo Michael A. , Mendenhall John M. , Kuwajima Masaaki , Harris Kristen M. 
Published: July 2014

ABSTRACTNascent zones and active zones are adjacent synaptic regions that share a postsynaptic density, but nascent zones lack the presynaptic vesicles found at active zones. Here dendritic spine synapses were reconstructed through serial section electron microscopy (3DEM) and EM tomography to investigate nascent zone dynamics during long‐term potentiation (LTP) in mature rat hippocampus. LTP was induced with theta‐burst stimulation, and comparisons were made with control stimulation in the same hippocampal slices at 5 minutes, 30 minutes, and 2 hours post‐induction and to perfusion‐fixed hippocampus in vivo. Nascent zones were present at the edges of ∼35% of synapses in perfusion‐fixed hippocampus and as many as ∼50% of synapses in some hippocampal slice conditions. By 5 minutes, small dense‐core vesicles known to transport active zone proteins moved into more presynaptic boutons. By 30 minutes, nascent zone area decreased, without significant change in synapse area, suggesting that presynaptic vesicles were recruited to preexisting nascent zones. By 2 hours, both nascent and active zones were enlarged. Immunogold labeling revealed glutamate receptors in nascent zones; however, average distances from nascent zones to docked presynaptic vesicles ranged from 170 ± 5 nm in perfusion‐fixed hippocampus to 251 ± 4 nm at enlarged synapses by 2 hours during LTP. Prior stochastic modeling suggests that decrease in glutamate concentration reduces the probability of glutamate receptor activation from 0.4 at the center of release to 0.1 just 200 nm away. Thus, conversion of nascent zones to functional active zones likely requires the recruitment of presynaptic vesicles during LTP. J. Comp. Neurol. 522:3861–3884, 2014. © 2014 Wiley Periodicals, Inc.
Adult stem cells in the knifefish cerebellum
Authors: Sîrbulescu Ruxandra F. , Ilieş Iulian , Vitalo Antonia G. , Trull Krystal , Zhu Jenny , Traniello Ian M. , Zupanc Günther K.H. 
Published: July 2014

ABSTRACTAdult neurogenesis has been described in dozens of brain regions in teleost fish, with the largest number of new neurons being generated in the cerebellum. Here, we characterized the cerebellar neural stem/progenitor cells (NSPCs) in the brown ghost knifefish (Apteronotus leptorhynchus), an established model system of adult neurogenesis. The majority of the new cerebellar cells arise from neurogenic niches located medially, at the interface of the dorsal/ventral molecular layers and the granular layer. NSPCs within these niches give rise to transit‐amplifying progenitors which populate the molecular layer, where they continue to proliferate during their migration toward target areas in the granular layer. At any given time, the majority of proliferating cells are located in the molecular layer. Immunohistochemical staining revealed that the stem cell markers Sox2, Meis1/2/3, Islet1, and, to a lesser extent, Pax6, are widely expressed in all regions of the adult cerebellum. A large subpopulation of these NSPCs coexpress S100, GFAP, and/or vimentin, indicating astrocytic identity. This is further supported by the specific effect of the gliotoxin l‐methionine sulfoximine, which leads to a targeted decrease in the number of GFAP+ cells that coexpress Sox2 or the proliferation marker PCNA. Pulse‐chase analysis of the label size associated with new cells after administration of 5‐bromo‐2′‐deoxyuridine demonstrated that, on average, two additional cell divisions occur after completion of the initial mitotic cycle. Overall numbers of NSPCs in the cerebellum niches increase consistently over time, presumably in parallel with the continuous growth of the brain. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 39–65, 2015
Increased frequency and function of KIR2DL1–3+ NK cells in primary HIV‐1 infection are determined by HLA‐C group haplotypes
Authors: Körner Christian , Granoff Mitchell E. , Amero Molly A. , Sirignano Michael N. , Vaidya Sagar A. , Jost Stephanie , Allen Todd M. , Rosenberg Eric S. , Altfeld Marcus 
Published: July 2014

The acquisition and maintenance of NK‐cell function is mediated by inhibitory killer‐cell immunoglobulin‐like receptors (KIRs) through their interaction with HLA class I molecules. Recently, HLA‐C expression levels were shown to be correlated with protection against multiple outcomes of HIV‐1 infection; however, the underlying mechanisms are poorly understood. As HLA‐C is the natural ligand for the inhibitory receptors KIR2DL1 and KIR2DL2/3, we sought to determine whether HLA‐C group haplotypes affect NK‐cell responses during primary HIV‐1 infection. The phenotypes and functional capacity of NK cells derived from HIV‐1‐positive and HIV‐1‐negative individuals were assessed (N = 42 and N = 40, respectively). HIV‐1 infection was associated with an increased frequency of KIR2DL1–3+ NK cells. Further analysis showed that KIR2DL1+ NK cells were selectively increased in individuals homozygous for HLA‐C2, while HLA‐C1‐homozygous individuals displayed increased proportions of KIR2DL2/3+ NK cells. KIR2DL1–3+ NK cells were furthermore more polyfunctional during primary HIV‐1 infection in individuals also encoding for their cognate HLA‐C group haplotypes, as measured by degranulation and IFN‐γ and TNF‐α production. These results identify a novel relationship between HLA‐C and KIR2DL+ NK‐cell subsets and demonstrate that HLA‐C‐mediated licensing modulates NK‐cell responses to primary HIV‐1 infection.
Electric‐Field Effects on Trimeric Mixed‐Valence Clusters
Authors: Klokishner Sophia I. , Roman Marianna A. , Reu Oleg S. 
Published: July 2014

AbstractThe manifestations of an external direct current (dc) electric field on the magnetic and polarizability characteristics of trimeric CuII–CuII–CuIII mixed‐valence clusters were examined. The temperature and field dependence of the magnitude of the mean dipole moment as well as of its components were calculated, and the anisotropy of the cluster polarizability was predicted. The low‐temperature limit of the cluster magnetic moment is determined by the competition between the tunneling and Heisenberg interactions and the interactions with the external electric field. The transition between two paramagnetic states of the cluster caused by the interaction with the electric field leads to the nontrivial field dependence of the magnetic moment. The external electric field offers a unique possibility to manipulate the polarizability and magnetic characteristics of trimeric mixed‐valence clusters.
A novel type of gas‐liquid contactor for post‐combustion capture cost reduction
Authors: Wardhaugh Leigh T. , Allport Andrew , Solnordal Christopher B. , Feron Paul H.M. 
Published: July 2014

AbstractA novel gas‐liquid contactor based on a rotating continuous thin liquid sheet is proposed for use in post‐combustion CO2 capture processes. This rotating liquid sheet (RLS) contactor is capable of providing a surface area equivalent to that of a packed column but without any packing material in the column. A small‐diameter axially located tube provides the liquid feed to the column through thin slots shaped in the form of helices or angled blades and designed in such a way as to create a continuous angled sheet of liquid. Rotation of this device causes the gas to be pumped through the contactor column at velocities comparable to that seen in conventional packed columns.The RLS contactor has the advantage of reducing or eliminating the need for external flue gas pumping, reducing entrainment of liquid droplets and the potential to utilize a wider range of capture solvent viscosities. An optimized design of the new contactor would result in a 30% reduction in the major equipment capital costs for post‐combustion CO2 capture and a 25% reduction in electrical power requirement. Capital cost reduction occurs as a result of eliminating the packing, reducing or eliminating the need for external flue gas pumping, and in vessel size reduction. Ongoing experimental and modeling work using computational fluid dynamics is addressing scale‐up issues and the development of an optimized design.© 2014 Society of Chemical Industry and John Wiley & Sons, Ltd
Synthesis of Bis(arylethynyl) Selenides by One‐Pot Protocol
Authors: Zhu Yun‐Xing , Zhao Zi‐Jian , Zhang Yang , Su Qiong , Peng Zhi‐Hong , An De‐Lie 
Published: July 2014

ABSTRACTAn efficient method without using terminal arylacetylenes as substrates for the synthesis of bis(arylethynyl) selenides 1 (ArCCSeCCAr) was described, and a series of compounds 1a−1m have been obtained by a one‐pot three‐step strategy from the corresponding bis(arylethanonyl) selenides. The mechanism was identified through trapping and characterization of a key intermediate 2a, and an elimination using it directly. The results from experiments indicated that the reaction procedure involves the formation of the enol phosphate and a subsequent base‐induced elimination.
Two‐year, randomized, controlled study of safinamide as add‐on to levodopa in mid to late Parkinson's disease
Authors: Borgohain Rupam , Szasz Jozsef , Stanzione Paolo , Meshram Chandrashekhar , Bhatt Mohit H. , Chirilineau Dana , Stocchi Fabrizio , Lucini Valentina , Giuliani Rodolfo , Forrest Emma , Rice Patricia , Anand Ravi ,   the Study 018 Investigators
Published: July 2014

AbstractIn a 6‐month double‐blind, placebo‐controlled study of Parkinson's disease patients with motor fluctuations, safinamide 50 and 100 mg/d significantly increased ON‐time without increasing dyskinesia. Further long‐term safinamide use in these patients was evaluated over an additional 18 months. Patients continued on their randomized placebo, 50, or 100 mg/d safinamide. The primary endpoint was change in Dyskinesia Rating Scale total score during ON‐time over 24 months. Other efficacy endpoints included change in ON‐time without troublesome dyskinesia, changes in individual diary categories, depressive symptoms, and quality of life measures. Change in Dyskinesia Rating Scale was not significantly different in safinamide versus placebo groups, despite decreased mean total Dyskinesia Rating Scale with safinamide compared with an almost unchanged score in placebo. Ad hoc subgroup analysis of moderate to severe dyskinetic patients at baseline (36% of patients) showed a decrease with safinamide 100 mg/d compared with placebo (P = 0.0317). Improvements in motor function, activities of daily living, depressive symptoms, clinical status, and quality of life at 6 months remained significant at 24 months. Adverse events and discontinuation rates were similar with safinamide and placebo. This 2‐year, controlled study of add‐on safinamide in mid‐to‐late Parkinson's disease with motor fluctuations, although not demonstrating an overall difference in dyskinesias between patients and controls, showed improvement in dyskinesia in patients at least moderately dyskinetic at baseline. The study additionally demonstrated significant clinical benefits in ON‐time (without troublesome dyskinesia), OFF‐time, activities of daily living, motor symptoms, quality of life, and symptoms of depression. © 2014 International Parkinson and Movement Disorder Society
Prevalence and risk factors of depressive disorder in caregivers of patients with head and neck cancer
Authors: Lee Yu , Lin Pao‐Yen , Chien Chih‐Yen , Fang Fu‐Min 
Published: July 2014

AbstractObjectiveThe purpose of this study is to examine the prevalence and risk factors of depressive disorder in caregivers of patients with head and neck cancer.MethodsStudy subjects were recruited from a multidisciplinary outpatient clinic for head and neck cancer in a medical center from February to July 2012. Caregivers of patients with head and neck cancer were enrolled and assessed using the Structured Clinical Interview for the DSM‐IV, Clinician Version, the Short Form 36 Health Survey, and the Family APGAR index. The main aim of the study was to examine the difference in demographic data and clinical characteristics between the caregivers with and without depressive disorders. In addition, a stepwise forward model of logistic regression was used to test the possible risk factors.ResultsOne hundred and forty‐three caregivers were included in the study. The most prevalent psychiatric disorder was depressive disorder (14.7%), followed by adjustment disorder (13.3%). Nearly one‐third of the caregivers had a psychiatric diagnosis. By using logistic regression analysis, it was found that unemployment (odds ratio (OR) = 3.16; 95% CI, 1.04–9.68), lower social functioning (OR = 1.43; 95% CI, 1.18–1.72), and lower educational level (OR = 1.16; 95% CI, 1.01–1.34) were significant risk factors for the depressive disorder.ConclusionsThe clinical implication of our results is the value of using the standardized structured interview for early diagnosis of depressive disorder in caregivers of head and neck cancer patients. Early screening and management of depression in these caregivers will raise their quality of life and capability to care patients. Copyright © 2014 John Wiley & Sons, Ltd.