bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor
Authors: Fu W , Sharma S S , Ma L , Chu B , Bui M M , Reed D , Pledger W J 
Published: March 2013

AbstractOsteosarcoma (OS) is an aggressive bone cancer typically observed in adolescents and young adults. Metastatic relapse accounts primarily for treatment failure, and obstacles to improving cure rates include a lack of efficacious agents. Our studies show apoptosis of OS cells prepared from localized and metastatic tumors by a novel drug combination: SCH727965 (SCH), a cyclin-dependent kinase inhibitor, and NVP-AUY922 (AUY) or other heat shock protein 90 inhibitor. SCH and AUY induced apoptosis when added simultaneously to cells and when AUY was added to and removed from cells before SCH addition. Sequential treatment was most effective when cells received AUY for ∼12 h and when SCH was presented to cells immediately after AUY removal. The apoptotic protein Bax accumulated in mitochondria of cotreated cells but was primarily cytosolic in cells receiving either agent alone. Additional data show that SCH and AUY cooperatively induce the apoptosis of other sarcoma cell types but not of normal osteoblasts or fibroblasts, and that SCH and AUY individually inhibit cell cycle progression throughout the cell cycle. We suggest that the combination of SCH and AUY may be an effective new strategy for treatment of OS.
The cell cycle and pluripotency
Authors: Hindley Christopher , Philpott Anna 
Published: March 2013

PSCs (pluripotent stem cells) possess two key properties that have made them the focus of global research efforts in regenerative medicine: they have unlimited expansion potential under conditions which favour their preservation as PSCs and they have the ability to generate all somatic cell types upon differentiation (pluripotency). Conditions have been defined in vitro in which pluripotency is maintained, or else differentiation is favoured and is directed towards specific somatic cell types. However, an unanswered question is whether or not the core cell cycle machinery directly regulates the pluripotency and differentiation properties of PSCs. If so, then manipulation of the cell cycle may represent an additional tool by which in vitro maintenance or differentiation of PSCs may be controlled in regenerative medicine. The present review aims to summarize our current understanding of links between the core cell cycle machinery and the maintenance of pluripotency in ESCs (embryonic stem cells) and iPSCs (induced PSCs).
Chemical analysis of giant stars in the young open cluster NGC 3114
Authors: Katime Santrich O. J. , Pereira C. B. , Drake N. A. 
Published: March 2013

Context. Open clusters are very useful targets for examining possible trends in galactocentric distance and age, especially when young and old open clusters are compared.
Aims. We carried out a detailed spectroscopic analysis to derive the chemical composition of seven red giants in the young open cluster NGC 3114. Abundances of C, N, O, Li, Na, Mg, Al, Ca, Si, Ti, Ni, Cr, Y, Zr, La, Ce, and Nd were obtained, as well as the carbon isotopic ratio.
Methods. The atmospheric parameters of the studied stars and their chemical abundances were determined using high-resolution optical spectroscopy. We employed the local-thermodynamic-equilibrium model atmospheres of Kurucz and the spectral analysis code MOOG. The abundances of the light elements were derived using the spectral synthesis technique.
Results. We found that NGC 3114 has a mean metallicity of [Fe/H] = −0.01 ± 0.03. The isochrone fit yielded a turn-off mass of 4.2 M⊙. The [N/C] ratio is in good agreement with the models predicted by first dredge-up. We found that two stars, HD 87479 and HD 304864, have high rotational velocities of 15.0 km s-1 and 11.0 km s-1; HD 87526 is a halo star and is not a member of NGC 3114.
Conclusions. The carbon and nitrogen abundance in NGC 3114 agree with the field and cluster giants. The oxygen abundance in NGC 3114 is lower compared to the field giants. The [O/Fe] ratio is similar to the giants in young clusters. We detected sodium enrichment in the analyzed cluster giants. As far as the other elements are concerned, their [X/Fe] ratios follow the same trend seen in giants with the same metallicity.
Temperature dependent transport and dielectric properties of cadmium titanate nanofiber mats
Authors: Imran Z. , Rafiq M. A. , Ahmad M. , Rasool K. , Batool S. S. , Hasan M. M. 
Published: March 2013

We investigate electrical and dielectric properties of cadmium titanate (CdTiO3) nanofiber mats prepared by electrospinning. The nanofibers were polycrystalline having diameter ∼50 nm-200 nm, average length ∼100 μm and crystallite size ∼25 nm. Alternating current impedance measurements were carried out from 318 K – 498 K. The frequency of ac signal was varied from 2 – 105 Hz. The complex impedance plots revealed two depressed semicircular arcs indicating the bulk and interface contribution to overall electrical behavior of nanofiber mats. The bulk resistance was found to increase with decrease in temperature exhibiting typical semiconductor like behavior. The modulus analysis shows the non-Debye type conductivity relaxation in nanofiber mats. The ac conductivity spectrum obeyed the Jonscher power law. Analysis of frequency dependent ac conductivity revealed presence of the correlated barrier hopping (CBH) in nanofiber mats over the entire temperature range.
The Mussel–Fish Relationship: A Potential New Twist in North America?
Authors: Wisniewski Jason M. , Bockrath Katherine D. , Wares John P. , Fritts Andrea K. , Hill Matthew J. 
Published: March 2013

AbstractNorth American freshwater mussels are critically imperiled organisms that generally require fish hosts in order to complete their life cycle. Although numerous studies have focused on the parasitic relationship between mussels and fishes, few have examined the benefits that mussels provide to other organisms. During sampling of Altamaha River, Georgia, we observed foreign eggs occurring within body cavities of native mussels across a 253‐km reach of the river basin. Eggs were recovered from 6% of the 757 mussels examined among seven sites. Foreign eggs were present in 17% and 18% of examined mussels at two sites. Using molecular techniques, eggs were identified as American Shad Alosa sapidissima. This discovery appears to be the first documented occurrence of native fish eggs in live North American mussels. Further research into the nature and mechanism of this symbiosis is warranted to assess whether this relationship is amensalistic, mutualistic, or commensalistic as American Shad and many freshwater mussels are species of conservation concern. A commensalistic or mutualistic relationship between these taxa may result in restoration activities affecting one species facilitating restoration of others.
Rationale and design of the SERVE‐HF study: treatment of sleep‐disordered breathing with predominant central sleep apnoea with adaptive servo‐ventilation in patients with chronic heart failure
Authors: Cowie Martin R. , Woehrle Holger , Wegscheider Karl , Angermann Christiane , d'Ortho Marie‐Pia , Erdmann Erland , Levy Patrick , Simonds Anita , Somers Virend K. , Zannad Faiez , Teschler Helmut 
Published: March 2013

AimsCentral sleep apnoea/Cheyne–Stokes respiration (CSA/CSR) is a risk factor for increased mortality and morbidity in heart failure (HF). Adaptive servo‐ventilation (ASV) is a non‐invasive ventilation modality for the treatment of CSA/CSR in patients with HF.MethodsSERVE‐HF is a multinational, multicentre, randomized, parallel trial designed to assess the effects of addition of ASV (PaceWave™, AutoSet CS™; ResMed) to optimal medical management compared with medical management alone (control group) in patients with symptomatic chronic HF, LVEF ≤45%, and predominant CSA. The trial is based on an event‐driven group sequential design, and the final analysis will be performed when 651 events have been observed or the study is terminated at one of the two interim analyses. The aim is to randomize ∼1200 patients to be followed for a minimum of 2 years. Patients are to stay in the trial up to study termination. The first patient was randomized in February 2008 and the study is expected to end mid 2015. The primary combined endpoint is the time to first event of all‐cause death, unplanned hospitalization (or unplanned prolongation of a planned hospitalization) for worsening (chronic) HF, cardiac transplantation, resuscitation of sudden cardiac arrest, or appropriate life‐saving shock for ventricular fibrillation or fast ventricular tachycardia in implantable cardioverter defibrillator patients.PerspectivesThe SERVE‐HF study is a randomized study that will provide important data on the effect of treatment with ASV on morbidity and mortality, as well as the cost‐effectiveness of this therapy, in patients with chronic HF and predominantly CSA/CSR.Trial registrationISRCTN19572887
FULMINANT CHORIORETINITIS AND PAPILLITIS SECONDARY TO COXSACKIEVIRUS B PRESENTING AS ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY WITH POSITIVE RESPONSE TO INTRAVENOUS IMMUNOGLOBULIN
Authors: Hollsten Jordan E. , McClintock Michael , Samy Hazem , Peden Marc , Kay Christine N. 
Published: March 2013

Purpose:
To describe a case of fulminant bilateral papillitis and chorioretinitis in the setting of positive coxsackievirus B titers, which convalesced months after the patient's presentation. The patient presented with an acute posterior multifocal placoid pigment epitheliopathy–like clinical picture and her visual acuity and visual field improved moderately after initiation of treatment with intravenous immunoglobulin.

Methods:
Case report of a white female with bilateral blurred vision is presented in this study.

Results:
A previously healthy 59-year-old white woman presented with a 3-day history of bilateral blurred vision. Initial visual acuity was hand motion in the right eye and count fingers in the left eye. Extensive workup and imaging was done and she was empirically started on intravenous antibiotics followed 24 hours later by intravenous steroids. The patient was found to have high titers of coxsackievirus B and sustained modest visual acuity and perimetry improvement in one eye after intravenous immunoglobulin infusion.

Conclusion:
A case of fulminant bilateral chorioretinitis and papillitis that resulted in bilateral vision loss despite high-dose steroids within 24 hours of initial loss in vision is presented in this study. The patient was found to have high titers of coxsackievirus B3, B4,B5 after presentation and her condition improved after treatment with intravenous immunoglobulin, suggesting a plausible immune component.
Collision monitoring and optimal collision avoidance manoeuvre for formation flying satellites
Authors: Zeng Guoqiang , Hu Min , Song Junling 
Published: March 2013

PurposeThe purpose of this paper is to evaluate the safety of formation flying satellites, and propose a method for practical collision monitoring and collision avoidance manoeuvre.Design/methodology/approachA general formation description method based on relative orbital elements is proposed, and a collision probability calculation model is established. The formula for the minimum relative distance in the crosstrack plane is derived, and the influence of J2 perturbation on formation safety is analyzed. Subsequently, the optimal collision avoidance manoeuvre problem is solved using the framework of linear programming algorithms.FindingsThe relative orbital elements are illustrative of formation description and are easy to use for perturbation analysis. The relative initial phase angle between the in‐plane and cross‐track plane motions has considerable effect on the formation safety. Simulations confirm the flexibility and effectiveness of the linear programming‐based collision avoidance manoeuvre method.Practical implicationsThe proposed collision probability method can be applied in collision monitoring for the proximity operations of spacecraft. The presented minimum distance calculation formula in the cross‐track plane can be used in safe configuration design. Additionally, the linear programming method is suitable for formation control, in which the initial and terminal states are provided.Originality/valueThe relative orbital elements are used to calculate collision probability and analyze formation safety. The linear programming algorithms are extended for collision avoidance, an approach that is simple, effective, and more suitable for on‐board implementation.
Design of an S‐duct intake for UAV applications
Authors: Papadopoulos Fotios , Valakos Ioannis , Nikolos Ioannis K. 
Published: March 2013

PurposeThe purpose of this paper is to design an S‐duct intake for unmanned aerial vehicles (UAVs) applications with good efficiency in a wide range of operating conditions.Design/methodology/approachA fully‐parametric 3‐D CAD model of the intake was constructed in order to produce different intake configurations, within specific geometric constraints, and to study the influence of geometry variation on efficiency. O‐type blocking methodology was adopted in order to construct the block‐structured mesh of hexahedral elements, used in the simulations. The commercial CFD code ANSYS‐CFX was used to compute the flow field inside the flow domain of each case considered. The Reynolds averaged Navier‐Stokes (RANS) equations are discretized using an implicit, vertex‐based finite volume method, combined with the shear stress transport (SST) two‐equation turbulence model and an automatic wall treatment.FindingsBy shortening the axial length the flow separation after the first turning becomes more pronounced and the losses are increasing. For very long ducts the increased internal wall area leads to increased wall friction and, consequently, to increased loss production.Originality/valueThe adoption of Gerlach‐shaped profiles for the design of the S‐duct resulted in a low pressure loss level for the optimal shape, although more uniform distribution of total pressure losses resulted for ducts longer than the optimal one, which should be taken into account in the design process.
Constrained predictive control of helicopters
Authors: Oktay Tugrul , Sultan Cornel 
Published: March 2013

PurposeThe purpose of this paper is to show the feasibility of constrained model predictive control (MPC) for sophisticated helicopter models which are derived by physical considerations.Design/methodology/approachPhysics‐based modeling is used to create control‐oriented helicopter models. Advanced constrained controllers are designed and tested for these sophisticated models.FindingsThe helicopter models are valid and constrained MPC shows considerable promise for robust tracking.Practical implicationsMPCs can be implemented for highly constrained helicopter flights.Originality/valueA complete process of control‐oriented, physics‐based model development for helicopters followed by MPC design is developed. It is also proved that constrained MPC can be used and implemented online to robustly track discontinuous helicopter trajectories with heterogeneous constraints, even when the models are sophisticated and physics based.
Blending optimal algorithm for heliocentric solar sailing
Authors: Shi Xiaoning , Guo Jifeng , Cui Naigang , Huang Rong 
Published: March 2013

PurposeThe purpose of this paper is to design a solar sail heliocentric transfer orbit which can meet the requirements of control system and capture orbit, and to provide the change of angles for attitude control system.Design/methodology/approachAiming at the problem of solar sail heliocentric transfer orbits design, this paper addresses the derivation of analytical optimal control law. The control laws can realize the combination of the control of each orbit element, but they can only give local optimal solution to meet the practical needs of mission. In order to solve this problem and meet the capture orbit and the attitude control system requirements, the modified genetic algorithm based on the analytical control law is introduced.FindingsThe algorithm addressed by this paper includes results closer to the global optimization, and also can meet the engineering constraints.Practical implicationsThe analytical optimal control law can be applied to the future onboard sail control systems. The blending optimal algorithm is demonstrated to be suitable as a method of preliminary design for solar sail deep space exploration mission.Originality/valueA blending optimal algorithm combining the analytical control law and genetic algorithm is proposed; the algorithm can search for global optimization based on the local optimal results of analytical control law.
Innovation, entrepreneurship and economic growth
Authors: Galindo Miguel‐Ángel , Méndez‐Picazo María‐Teresa 
Published: March 2013

PurposeThe main aim of this paper is to analyze the relationship between innovation and economic growth, following the Schumpeter approach, considering the entrepreneurship activity.Design/methodology/approachSeveral hypotheses are tested considering three equations, for the case of ten developed countries. To estimate the equations, generalized least square (GLS)‐cross‐section weights and panel least squares methodologies for the period 2001‐2009 have been used.FindingsInnovation plays a central role in the economic growth process and the entrepreneur is the vehicle to introduce the new technologies to improve the firms' activity and to obtain higher profits. It is also necessary to include in this process other variables: social climate and the role of institutions.Practical implicationsSome measures can design from these results to improve innovation and entrepreneurship activity, which would have positive effects on economic growth.Originality/valueSchumpeterian approach is developed for this analysis, and empirical estimations are carried out to test hypotheses on economic growth and innovation, considering not only the traditional quantitative variables but also qualitative ones, having a wider view about the process. Drucker statement on innovation effects on entrepreneurship activity is also tested.
Open source solutions for libraries: ABCD vs Koha
Authors: Macan Bojan , Vanesa Fernández Gladys , Stojanovski Jadranka 
Published: March 2013

PurposeThe purpose of this study is to present an overview of the two open source (OS) integrated library systems (ILS) – Koha and ABCD (ISIS family), to compare their “next‐generation library catalog” functionalities, and to give comparison of other important features available through ILS modules.Design/methodology/approachTwo open source ILSs, Koha and ABCD, were compared in‐depth according to their functionalities and characteristics. A checklist was created for each module: acquisition, cataloging, serials, patron management and circulation, reports and statistics, and administration. For an online catalog module, a separate checklist with “new generation catalog” characteristics was created. The authors also defined an additional set of criteria which could influence the decision process and selection of appropriate ILS like funding, metadata schema, preferred ILS functionalities, provided support, and the role of the IT department, and computer and network infrastructure in the library.FindingsEvaluation of ILSs reveals that Koha has more functionalities than ABCD, especially those connected with the “next generation library catalog”. If a library is using UNIMARC or MARC21 format for bibliographic description and has a good IT support, Koha is an open source ILS with a wide community which has to be considered for implementation. ABCD has great metasearch possibilities and is worth considering by libraries using other or no metadata schemas or without IT support.Research limitations/implicationsThe research was limited to two research libraries and their praxis and experiences. Further analysis can include other open source ILSs.Practical implicationsThis study can help libraries preparing to migrate to open source ILS to choose an appropriate one.Originality/valueThis is the first comprehensive study conducted on Koha and ABCD comparing all modules in detail.
Construct DTPB model by using DEMATEL: a study of a university library website
Authors: Lee Yu‐Cheng , Hsieh Yi‐Fang , Guo Yau‐Bin 
Published: March 2013

PurposeTraditional studies on a decomposed theory of planned behavior (DTPB) analyze the relationship of variables through a structural equation model. If certain variables do not fully comply with the independent hypothesis, it is not possible to conduct proper analysis, which leads to false conclusions. To solve these problems, the aim of this research is to adopt an expert opinion‐driven decision making trial and evaluation laboratory (DEMATEL), and re‐establish the causal relationship and the degree of interrelationship of DTPB variables.Design/methodology/approachThis research used a university library website as an individual case, and illustrated the benefits of constructing DTPB model by using DEMATEL through the opinions of 23 experts surveyed by questionnaires.FindingsAccording to the analysis result of constructing DTPB model by using DEMATEL, when DTPB variables were distributed within quadrants of high centrality and degree of causality, they became the key influential variables; when distributed within quadrants of low centrality and degree of causality, the variables needed urgent management.Originality/valueWhen traditional DTPB does not consider the direct and indirect relationships among variables, the original causal relationship of variables will be influenced, and then the original variables cannot fully demonstrate their causal relationship. Therefore the feasibility and effect of constructing DTPB model by using DEMATEL proposed in this research are proved through individual cases.
User acceptance of long‐term evolution (LTE) services
Authors: Park Eunil , Joon Kim Ki 
Published: March 2013

PurposeThe aim of this paper is to propose an integrated path model in order to explore user acceptance of long‐term evolution (LTE) services by examining potential causal relationships between key psychological factors and user intention to use the services.Design/methodology/approachOnline survey data collected from 1,344 users are analysed with the structural equation modelling (SEM) method.FindingsResults reveal that satisfaction is the most crucial factor contributing to user intention to use LTE services. Other factors, including perceived usefulness, attitude, and system and service quality, also have notable impacts on user intention. Furthermore, system and service quality is affected by both perceived processing speed and perceived mobility, while perceived usefulness is primarily influenced by perceived adaptivity. In addition, four factors (perceived usefulness, adaptivity, processing speed, and system and service quality) are found to be major determinants of the user attitudes toward the services.Originality/valueThe present study provides valuable insights to understanding key factors that affect user perceptions of and intention to use LTE services.