bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue Inhibitors of Metalloproteinases (
TIMPs
): Inhibition of Zn‐Dependent Metallopeptidases
Authors: Batra Jyotica , Radisky Evette S 
Published: March 2014

Abstract

Tissue inhibitors of metalloproteinases (
TIMPs
) are protein protease inhibitors that target zinc‐dependent metallopeptidases of the matrix metalloproteinase (
MMP
), disintegrin metalloproteinase (
ADAM
), and disintegrin metalloproteinase with thrombospondin motif (
ADAM‐TS
) families.
TIMPs
form very tight 1:1 stoichiometric complexes with target peptidases that are centered on the peptidase catalytic zinc ion, and in which three zinc–ligand bonds are donated by the peptidase and two zinc–ligand bonds are donated by the
TIMP
. While this general structural mechanism of inhibition is highly conserved among all complexes studied, the reported binding constants for
TIMP
–peptidase interactions span many orders of magnitude, revealing overlapping but distinct specificity. Nonconserved epitopes at the periphery of the
TIMP
/peptidase interface contribute to differential recognition among complexes. This article summarizes currently available structural and biochemical data relating to molecular recognition in
TIMP
–peptidase complexes.
Graphene
Authors: Sur Ujjal K. 
Published: March 2014

AbstractGraphene, a one‐atom‐thick planar sheet of sp2‐bonded carbon atoms packed in a honeycomb lattice, is considered to be the mother of all graphitic materials such as fullerenes, carbon nanotubes, and graphite. Graphene, the two‐dimensional form of graphite, was first isolated in 2004 by Geim and Novoselov of Manchester University, the United Kingdom. Today, graphene is the most attractive nanomaterial not only because it is the thinnest known material and the strongest material ever measured in the universe, but also because of its excellent electrical, thermal, mechanical, electronic, and optical properties. It has potential applications ranging from sensors, field‐effect transistors, displays, energy storage, and photovoltaic devices. The aim of this article is to provide an updated overview of graphene in terms of synthesis, historical background, and some of the amazing properties and potential applications ranging from sensors to energy storage devices. In addition to these, special emphasis has been given to various graphene/polymer nanocomposites in terms of fabrication, properties, and potential applications.
Has the CSR engagement of electrical companies had an effect on their performance? A closer look at the environment
Authors: Miras‐Rodríguez María del Mar , Carrasco‐Gallego Amalia , Escobar‐Pérez Bernabé 
Published: March 2014

AbstractEven though electrical companies attain a top ranking in the publication of CSR reports, they are often accused of 'green‐washing' due to their bad environmental reputation. The current economic crisis is testing their real CSR commitment more than ever, especially when this goes beyond its economic consequences.Based on a worldwide sample of electrical companies, we are going to study why companies are being socially responsible. We wish to know if it is due to the impact on the firms' performance or whether there are other motives (legitimation, improving their reputation) that lead companies to carry out these practices. We will also consider if it changes across the kind of CSR action considered.The results show that there is an economic justification beyond the socially responsible behaviour of the electrical companies. Additionally, most kinds of CSR action (community, diversity, corporate governance, product responsibility) are also carried out looking for economic rewards. However, the CSR actions oriented to the environment are mainly motivated by their need to improve their image and reverse their negative impact. Copyright © 2014 John Wiley & Sons, Ltd and ERP Environment
ChemInform Abstract: Partial Spin Ordering and Complex Magnetic Structure in BaYFeO4: A Neutron Diffraction and High Temperature Susceptibility Study.
Authors: Thompson Corey M. , Greedan John E. , Garlea V. Ovidiu , Flacau Roxana , Tan Malinda , Nguyen Phuong‐Hieu T. , Wrobel Friederike , Derakhshan Shahab 
Published: March 2014

AbstractBaYFeO4 is prepared by solid state reaction of stoichiometric amounts of BaCO3, Y2O3, and Fe2O3 in air (1.
ChemInform Abstract: Two New 3‐D Boratopolyoxovanadate Architectures Based on the [V12B16O50(OH)8]12‐ Cluster with Different Metal Linkers.
Authors: Liu Xing , Zhou Jian , Xiao Hong‐Ping , Kong Chunyang , Zou Huahong , Tang Qiuling , Li Jianhui 
Published: March 2014

AbstractCompounds (IV) and (VI) are characterized by single crystal XRD.
ChemInform Abstract: Tetrahedral Connection of ε‐Keggin‐Type Polyoxometalates to Form an All‐Inorganic Octahedral Molecular Sieve with an Intrinsic 3D Pore System.
Authors: Zhang Zhenxin , Sadakane Masahiro , Murayama Toru , Izumi Shoko , Yasuda Nobuhiro , Sakaguchi Norihito , Ueda Wataru 
Published: March 2014

AbstractA Bi‐capped ε‐VMo9.4V2.6O40 Keggin‐type core is prepared hydrothermally from aqueous solutions of (NH4)6Mo7O24, VOSO4, and Bi(OH)3 (autoclave, 448 K, 48 h, 3.3% yield).
ChemInform Abstract: Regioselective Halogenation of 2‐Substituted 1,2,3‐Triazoles via sp2 C—H Activation.
Authors: Tian Qingshan , Chen Xianmin , Liu Wei , Wang Zechao , Shi Suping , Kuang Chunxiang 
Published: March 2014

AbstractThe first example of a Pd‐catalyzed ortho‐halogenation of 2‐substituted 1,2,3‐triazoles (I) and (III) via C—H activation is described.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of 3(2H)‐Furanones with Adjacent Quaternary and Tertiary Stereocenters.
Authors: He Wujun , Jing Linhai , Qin Dabin , Wang Rongming , Xie Xiaohua , Wu Song 
Published: March 2014

AbstractMichael addition of furanones to α,β‐unsaturated ketones in the presence of a cinchona‐based chiral catalyst provides the title products (III) with high enantioselectivity and low to moderate diastereoselectivity.
ChemInform Abstract: Bromoform Activation. TiCl4—Mg‐Promoted CHBr2‐ and CBr3‐ Transfer to a Variety of Aldehydes and Ketones.
Authors: Yan Tu‐Hsin , Chang Su‐Haur , Chang Cheng‐Ta , Lin Chia‐Kuan , Liu Chien‐Yu 
Published: March 2014

AbstractThe system TiCl4—Mg can mediate addition of bromoform to a variety of aldehydes and ketones to form either dibromomethyl carbinols or tribromomethyl carbinols dependent on the reaction conditions.
ChemInform Abstract: A Copper‐Free, Cross‐Coupling of Terminal Alkynes with Hetaryl Halides.
Authors: Arsenyan Pavel , Rubina Kira , Vasiljeva Jelena , Belyakov Sergey 
Published: March 2014

AbstractAn inexpensive Pd‐catalyzed cross‐coupling reaction of haloarenes (I) with terminal alkynes is developed to yield the expected internal alkynes (III).
ChemInform Abstract: Cooperative Catalysis: Combining an Achiral Metal Catalyst with a Chiral Broensted Acid Enables Highly Enantioselective Hydrogenation of Imines.
Authors: Tang Weijun , Johnston Steven , Li Chaoqun , Iggo Jonathan A. , Bacsa John , Xiao Jianliang 
Published: March 2014

AbstractThe catalytic system of title can be employed on imines derived from aromatic as well as aliphatic ketones.
ChemInform Abstract: Copper‐Catalyzed C(sp2)—H Amidation of Unactivated Arenes by N‐Tosyloxycarbamates.
Authors: John Alex , Byun Jeena , Nicholas Kenneth M. 
Published: March 2014

AbstractOptimal reaction conditions are elaborated for the amidation of benzene with N‐tosyloxycarbamate (I).
ChemInform Abstract: p‐Nitrophenyl Ethylthioester in Enantioselective Organocatalytic Michael Additions: Different Behavior of β‐Aryl and β‐Alkyl Enals.
Authors: Duce Sara , Jorge Maria , Alonso Ines , Garcia Ruano Jose Luis , Cid M. Belen 
Published: March 2014

AbstractThe differences in the reactivity of the thioesters (I) with β‐alkyl and β‐aryl‐substituted enals (II) are overcome by optimization allowing the synthesis of diastereomeric mixtures of Michael adducts (III) and (IV).
ChemInform Abstract: Enantioselective Oxidative Coupling of 2‐Naphthol Derivatives by Copper‐(R)‐1,1′‐binaphthyl‐2,2′‐diamine‐TEMPO Catalyst.
Authors: Alamsetti Santosh Kumar , Poonguzhali Elamvazhuthi , Ganapathy Dhandapani , Sekar Govindasamy 
Published: March 2014

AbstractAddition of TEMPO to the (R)‐BINAM‐CuCl complex is crucial as it increases dramatically the reaction rate and selectivity of the reaction at room temperature.
ChemInform Abstract: Enantioselective Synthesis of 1,2,4‐Triazolines Catalyzed by a Cinchona Alkaloid‐Derived Organocatalyst.
Authors: Shao Qian , Chen Jiean , Tu Meihua , Piotrowski David W. , Huang Yong 
Published: March 2014

AbstractA highly enantioselective protocol for the synthesis of polysubstituted 1,2,4‐triazolines (IV), that is complementary to existing protocols, from azlactones (I) and azodicarboxylates (II) using a chiral organocatalyst is reported.
ChemInform Abstract: Rauhut—Currier‐Type Reaction with Morita—Baylis—Hillman Carbonates of 2‐Cyclohexenone and Alkylidenemalononitriles to Access Chromene Derivatives.
Authors: Peng Jing , Huang Xin , Zheng Peng‐Fei , Chen Ying‐Chun 
Published: March 2014

AbstractThe convenient metal‐free one‐pot procedure allows the synthesis of highly functionalized chromene derivatives through a domino Rauhut—Currier‐type reaction, cyclization, and isomerization process.
ChemInform Abstract: Domino Knoevenagel Condensation/Intramolecular Aldol Cyclization Route to Diverse Indolizines with Densely Functionalized Pyridine Units.
Authors: Kim Myungock , Jung Youngeun , Kim Ikyon 
Published: March 2014

AbstractIt offers a new, facile, and efficient approach to a number of indolizine derivatives.
ChemInform Abstract: A Facile Approach to Chiral 1,4‐Benzodioxane Toward the Syntheses of Doxazosin, Prosympal, Piperoxan, and Dibozane.
Authors: Rouf Abdul , Aga Mushtaq A. , Kumar Brijesh , Taneja Subhash Chandra 
Published: March 2014

AbstractStarting from commercially available inexpensive optically active diol (I) the synthesis of optically active 2‐hydroxymethyl‐1,4‐benzodioxane (V) is developed and its use as common precursor in the synthesis of the title compounds doxazosin (XI), prosympal (XIIIa), piperoxan (XIIIb), and dibozane (XV) is demonstrated.
ChemInform Abstract: Copper‐Catalyzed Activation of α‐Amino Peroxy and Hydroxy Intermediates to Iminium Ion Precursor: An Access to C4‐Substituted 3,4‐Dihydroquinazolines via Oxidative Cross Coupling Strategy.
Authors: Kumar R. Arun , Saidulu G. , Sridhar Balasubramanian , Liu Shiuh Tzung , Reddy K. Rajender 
Published: March 2014

AbstractCoupling of (2‐aminobenzyl)anilines with aromatic aldehydes followed by tBuOOH‐mediated oxidation leads to α‐amino peroxy and hydroxy intermediates.
ChemInform Abstract: Acid‐Mediated Cyclizations of SEM‐Protected Heterocyclic Anilines and Adjacent Hydroxyls of Enol‐Ethers.
Authors: Meng Zhaoyang , Sun Binyuan , Reddy Panduranga Adulla , Siddiqui M. Arshad 
Published: March 2014

AbstractSubstrates (I) undergo unexpected acid mediated cyclization involving the Sem‐protecting amino group and a neighboring enol ether moiety to produce tricyclic heterocycles (II).
ChemInform Abstract: Structure—Activity Relationships of the Aromatic Site in Novel Anticonvulsant Pyrrolo[1,2‐a]pyrazine Derivatives.
Authors: Dawidowski Maciej , Wilczek Marcin , Kubica Krzysztof , Skolmowski Michal , Turlo Jadwiga 
Published: March 2014

AbstractA variety of novel, chiral 4‐arylpyrrolopyrazine derivatives (II) are synthesized and evaluated for their anticonvulsant activity.
ChemInform Abstract: Synthesis of Densely Functionalized 5‐Halogen‐1,3‐oxazin‐2‐ones by Halogen‐Mediated Regioselective Cyclization of N‐Cbz‐Protected Propargylic Amines: A Combined Experimental and Theoretical Study.
Authors: Monleon Alicia , Blay Gonzalo , Domingo Luis R. , Munoz M. Carmen , Pedro Jose R. 
Published: March 2014

AbstractThe halocyclization reaction of chiral propargylic amines (I) proceeds with complete regioselectivity, taking place through a 6‐endo‐dig process regardless of the nature of the halogen and of the substituents in the starting material.
ChemInform Abstract: Design and Synthesis of New Hybrid Triazine‐Indole Derivatives as Potential Antimicrobial Agents Against Hospital Resistant Strains.
Authors: Al‐Qawasmeh Raed A. , Khanfar Monther A. , Semreen Mohamad H. , Abu Odeh Raed , Al‐Tel Taleb H. 
Published: March 2014

AbstractA microwave‐assisted protocol for the synthesis of triazine‐indole derivatives is presented.
ChemInform Abstract: Furo‐ and Thieno‐Fused 1,3‐Diazepine‐4,6‐diones.
Authors: Ozer Merve Sinem , Koza Gani , Sahin Ertan , Balci Metin 
Published: March 2014

AbstractStarting from the furan (I) possessing two adjacent ester groups the synthesis of furo‐fused diazepinedione derivatives (VI) and (VII) is developed.
ChemInform Abstract: A Silicon‐Position Dependent 6‐endo‐trig Cyclization During Tsuji—Trost Alkylation.
Authors: Agarwal Jyoti , Commandeur Claude , Malacria Max , Thorimbert Serge 
Published: March 2014

AbstractThe preparation of two silylated cyclohexenes by using a Tsuji—Trost palladium‐catalyzed cyclization is described.
ChemInform Abstract: Platinum‐Catalyzed One‐Pot Alkenylation of Aldehydes Using Alkynes and Triethylsilane: Dual Catalysis by Platinum(II) Chloride.
Authors: Kinoshita Hidenori , Uemura Ryousuke , Fukuda Daiki , Miura Katsukiyo 
Published: March 2014

AbstractThe title alkenylation proceeds with complete regioselectivity and is tolerant to a reasonable range of functional groups.
ChemInform Abstract: Triazolium Cations: From the “Click” Pool to Multipurpose Applications
Authors: Aizpurua Jesus M. , Fratila Raluca M. , Monasterio Zaira , Perez‐Esnaola Nerea , Andreieff Elena , Irastorza Aitziber , Sagartzazu‐Aizpurua Maialen 
Published: March 2014

AbstractReview: 62 refs.
Comparison of Prasugrel and Bivalirudin vs Clopidogrel and Heparin in Patients With ST‐Segment Elevation Myocardial Infarction: Design and Rationale of the Bavarian Reperfusion Alternatives Evaluation (BRAVE) 4 Trial
Authors: Schulz Stefanie , Richardt Gert , Laugwitz Karl‐Ludwig , Mehran Roxana , Gershlick Anthony H. , Morath Tanja , Mayer Katharina , Neudecker Julia , Tölg Ralph , Ibrahim Tareq , Hauschke Dieter , Braun Daniel , Schunkert Heribert , Kastrati Adnan , Mehilli Julinda ,   for the Bavarian Reperfusion Alternatives Evaluation (BRAVE) 4 Investigators
Published: March 2014

ABSTRACTPrimary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for patients with ST‐segment elevation myocardial infarction (STEMI). Effective and safe adjunct antithrombotic therapy is a major determinant for short‐ and long‐term outcomes after primary PCI. Two separate studies have shown significant benefits vs conventional therapy for 2 recently approved drugs. In the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS‐AMI) trial, bivalirudin after pretreatment with clopidogrel resulted in improved net clinical outcome compared with heparin plus glycoprotein IIb/IIIa inhibitors. However, during the first 24 hours after PCI, there was an increase in stent thrombosis rates with bivalirudin. In the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel—Thrombolysis In Myocardial Infarction (TRITON‐TIMI) 38 trial, prasugrel was superior to clopidogrel in patients with acute coronary syndrome with and without ST‐segment elevation. The synergic actions of prasugrel and bivalirudin may maximize the benefit of antithrombotic therapy for STEMI patients undergoing primary PCI. However, no specifically designed studies have so far compared the combination of prasugrel plus bivalirudin with that of clopidogrel plus unfractionated heparin in these patients. The Bavarian Reperfusion Alternatives Evaluation (BRAVE) 4 study is a randomized, open‐label, multicenter trial aimed to test the hypothesis that a strategy based on prasugrel plus bivalirudin is superior to a strategy based on clopidogrel plus unfractionated heparin in terms of net clinical outcome in STEMI patients with planned primary PCI.
Workload resampling for performance evaluation of parallel job schedulers
Authors: Zakay Netanel , Feitelson Dror G. 
Published: March 2014

SUMMARYEvaluating the performance of a computer system is based on using representative workloads. Common practice is to either use real workload traces to drive simulations or use statistical workload models that are based on such traces. Such models allow various workload attributes to be manipulated, thus providing desirable flexibility, but may lose details of the workload's internal structure. To overcome this, we suggest to combine the benefits of real traces and flexible modeling. Focusing on the problem of evaluating the performance of parallel job schedulers, we partition the trace of submitted jobs into independent subtraces representing different users and then recombine them in various ways, while maintaining features such as long‐range dependence and the daily and weekly cycles of activity. This facilitates the creation of longer workload traces that enable longer simulations, the creation of multiple statistically similar workloads that can be used to gauge confidence intervals, the creation of workloads with different load levels, and increasing the frequency of specific events like large surges of activity. Copyright © 2014 John Wiley & Sons, Ltd.
Overexpression of EphB4, EphrinB2, and epidermal growth factor receptor in papillary thyroid carcinoma: A pilot study
Authors: Sharma Giriraj K. , Dhillon Vaninder K. , Masood Rizwan , Maceri Dennis R. 
Published: March 2014

AbstractBackgroundThe purpose of this study was to examine the differential expression of EphB4, EphrinB2, and epidermal growth factor receptor (EGFR) genes in papillary thyroid carcinoma (PTC) and evaluate their association with lymph node metastasis.MethodsEphB4, EphrinB2, and EGFR expression in 21 matched tumors and surrounding normal thyroid tissues were evaluated by complementary DNA (cDNA) microarray, Western blot, and immunohistochemistry (IHC).ResultsWe noted a statistically significant overexpression of EphB4, EphrinB2, and EGFR in tumor versus normal tissue based on cDNA microarray, Western blot, and IHC analysis. EphB4 and EphrinB2 overexpression were significantly associated with the presence of lymph node disease.ConclusionOverexpression of EphB4, EphrinB2, and EGFR are associated with PTC, whereas EphB4 and EphrinB2 overexpression are associated with lymph node metastases. These genes may be potential biomarkers for identification of subclinical lymph node involvement in PTC and potential small‐molecule targets for pharmacotherapy research. © 2014 Wiley Periodicals, Inc. Head Neck 37: 964–969, 2015
BEYOND THE PROMISES OF TECHNOLOGY: A REVIEW OF THE DISCOURSES AND ACTORS WHO MAKE DRIP IRRIGATION
Authors: Venot Jean‐Philippe , Zwarteveen Margreet , Kuper Marcel , Boesveld Harm , Bossenbroek Lisa , Kooij Saskia Van Der , Wanvoeke Jonas , Benouniche Maya , Errahj Mostapha , Fraiture Charlotte De , Verma Shilp 
Published: March 2014

ABSTRACTDrip irrigation has long been promoted as a promising way to meet today's world water, food and poverty challenges. In most scientific and policy documents, drip irrigation is framed as a technological innovation with definitive intrinsic characteristics—that of efficiency, productivity and modernity. Based on evidence from North and West Africa as well as South Asia, we show that there are multiple actors involved in shaping this imagery, the legitimacy of which largely stems from an engineering perspective that treats technology and potential as ‘truths’ that exist independently of the context of use. Rather than ascribing the advent of drip irrigation as a successful technology to intrinsic technical features, this paper proposes to see it as grounded in the ability drip irrigation has to lend itself to multiple contexts and discourses that articulate desirable futures. We thus adopt a view of technology whereby the ‘real’ (i.e. the drip irrigation hardware) acquires its characteristics only through, and within, the network of institutions, discourses and practices that enact it. Such a perspective sheds light on the iterative alignments that take place between hardware and context and treat these as inherent features, rather than externalities, of the innovation process. Copyright © 2014 John Wiley & Sons, Ltd.
Evaluating the safety and efficacy of the 1,440‐nm laser in the treatment of photodamage in Asian skin
Authors: Marmon Shoshana , Shek Samantha Y. N. , Yeung C.K. , Chan Nicola P.Y. , Chan Johnny CY , Chan Henry H.L. 
Published: March 2014

ABSTRACTBackground and ObjectiveAs the demand for diminished procedure‐associated downtime continues to increase, nonablative fractional laser resurfacing is becoming a more popular intervention in the progression of photoaging. Patients with pigmented skin and a mild degree of photodamage may be particularly suited for a less intensive laser treatment. In this study, we have evaluated the safety and efficacy of a low energy, low density 1,440‐nm fractional laser in the treatment of multiple signs of photoaging including dyspigmentation, wrinkling, tissue laxity, enlarged pores, and skin roughness in Asians.Study Design/Materials and MethodsTen Chinese subjects with Fitzpatrick skin types III–V and visible signs of photodamage participated in this study. Patients received four treatments at 2‐week intervals with a 1,440‐nm diode‐based fractional laser. Photographs were taken at baseline, 2 weeks after each of the first three treatments and 4 weeks after the final treatment. Images were evaluated independently by two physicians. Clinical improvement and adverse events were analyzed. Discomfort, heat sensation and overall patient satisfaction associated with the procedure were also quantified.ResultsIn this prospective single‐arm study, signs of photoaging were examined after treatment with the 1,440‐nm laser. Here we show that a series of four treatments with this device produced a mild improvement in skin texture, pigmentation, and wrinkling. Changes in pore size and skin laxity failed to reach statistical significance. Immediate after‐effects of the procedure included erythema and edema which were transient and left no permanent sequela. A significant proportion of patients reported some degree of discomfort during the procedure despite use of a topical anesthetic. One patient developed a discrete, localized area of post‐inflammatory hyperpigmentation which completely resolved by the final follow up visit.ConclusionThe low energy, low density nonablative 1,440‐nm fractional laser produces a mild improvement in select signs of photodamage after four treatments without any long‐term adverse effects. Lasers Surg. Med. 46:375–379, 2014. © 2014 Wiley Periodicals, Inc.
Thermo‐Mechanical and Antibacterial Properties of Soybean Oil‐Based Cationic Polyurethane Coatings: Effects of Amine Ratio and Degree of Crosslinking
Authors: Garrison Thomas F. , Zhang Zongyu , Kim Hyun‐Jung , Mitra Debjani , Xia Ying , Pfister Daniel P. , Brehm‐Stecher Byron F. , Larock Richard C. , Kessler Michael R. 
Published: March 2014

AbstractSoybean‐oil‐based cationic polyurethane coatings with antibacterial properties have been prepared with a range of different molar ratios of hydroxyl groups from an amine diol. A second series of polyurethane coatings were prepared from soy polyols with different hydroxyl numbers. All of the cationic PU dispersions and films exhibit inhibitory activity against three foodborne pathogens: Salmonella enterica ssp. enterica ser. Typhimurium, Listeria monocytogenes, and Staphylococcus aureus. It is generally observed that increases in the ratio of ammonium cations improve the antibacterial performance. Reduction of the crosslink density by decreasing the hydroxyl number of the soy polyol also results in slightly improved antibacterial properties. Higher glass transition temperatures and improved mechanical properties are observed with corresponding increases in the molar ratios of the amine diol and the diisocyanate. These results show that the mechanical properties of these coatings can be tuned, while maintaining good antibacterial activity.