bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactive focus + context medical data exploration and editing
Authors: Kirmizibayrak Can , Wakid Mike , Yim Yeny , Hristov Dimitre , Hahn James K. 
Published: July 2013

ABSTRACTVolumetric datasets are increasingly used in medical applications. In many of these applications, visualization and interaction is generally performed on cross‐sectional two‐dimensional (2D) views of three‐dimensional (3D) imaging modalities. Displaying 3D volumetric medical datasets on traditional 2D screens can present problems such as occlusion and information overload, especially when multiple data sources are present. Displaying desired information while showing the relationship to the rest of the dataset(s) can be challenging. In this paper, we present an interactive focus + context visualization approach that uses the volumetric Magic Lens interaction paradigm. We propose to use the Magic Lens as a volumetric brush to perform volume editing tasks, therefore combining data exploration with volumetric editing. Polygon‐assisted ray casting methods are used for real‐time rendering and editing frame rates, while providing compact storage of editing states for undo/redo operations. We discuss the application of our methods to radiation therapy, which is an important cancer treatment modality. We envision that this approach will improve the treatment planning process by improving the therapists' understanding of information from various sources and will help identify if the alignment of the patient in the treatment room coincides with the prepared treatment plan. Copyright © 2013 John Wiley & Sons, Ltd.
First report of a novel polymer‐free dual‐drug eluting stent in de novo coronary artery disease: Results of the first in human BICARE trial
Authors: Yu Mengyue , Xu Bo , Kandzari David E. , Wu Yongjian , Yan Hongbing , Chen Jue , Qian Jie , Qiao Shubin , Yang Yuejin , Gao Run‐Lin 
Published: July 2013

BackgroundPersistence of stent polymer coating has been associated with incomplete endothelialization, expansive vessel remodeling, neoatherosclerosis, and delayed healing associated with inflammation that may contribute to late adverse events.MethodsThe BICARE (Lepu Medical, Beijing, China) stent is a novel polymer‐free, nanotechnology‐based stent eluting sirolimus and probucol. As a first in human feasibility study, patients with a single de novo native coronary stenosis <30 mm in length and with reference vessel diameter from 2.5 to 4.0 mm underwent revascularization with the BICARE stent. The primary endpoint of target lesion failure (TLF) was assessed at 30 days. Secondary endpoints included in‐stent late lumen loss and proportion of uncovered or malapposed stent struts by optical coherence tomography at 4‐month angiographic surveillance.ResultsAmong 32 consecutive patients (age, 55.7 ± 8.7 years; men, 62.5%; diabetes, 18.8%), the average baseline reference vessel diameter and lesion length were 2.85 ± 0.48 mm and 15.0 ± 5.6 mm, respectively. At 30 days there was no occurrence of TLF. At 4 months (angiographic follow‐up, N=32), angiographic in‐stent late loss was 0.14 ± 0.19 mm, and the in‐stent binary restenosis rate was 3.1%. Complete strut coverage was 98.2% with 0.2% malapposition among 16,751 analyzed struts. At 18 months, TLF occurred in 3 (9.4%) patients related to repeat revascularization with no adverse safety events identified.ConclusionsThe preliminary feasibility and safety of a polymer‐free, dual‐drug eluting stent are demonstrated by absence of early adverse safety events and favorable angiographic suppression of neointimal hyperplasia. Stent imaging suggests favorable healing with extensive stent strut coverage and very low malapposition. These findings further inform comparison with biopermanent polymer DES. © 2013 Wiley Periodicals, Inc.
Construction of Optically Active Quaternary Propargyl Amines by Highly Enantioselective Zinc/BINOL‐Catalyzed Alkynylation of Ketoimines
Authors: Huang Gaochao , Yin Zengsheng , Zhang Xingang 
Published: July 2013

AbstractA general and efficient method for the highly enantioselective alkynylation of ketoimines through a zinc/1,1′‐bi‐2‐naphthol (BINOL)‐catalyzed process has been developed. A variety of ketoimines, including α‐fluoroalkyl α‐imine esters, α‐aryl α‐imine esters, and trifluoromethyl aryl ketoimines, are applicable and provide their corresponding quaternary propargyl amines in excellent yields with high ee values (up to 99 % ee). Both the steric and electronic effects of substituents at the 3,3′ positions of BINOL are critical for the reaction efficiency and enantioselectivity. To demonstrate the usefulness of the method, (R)‐α‐CF3 α‐proline has been prepared in a highly efficient manner. The notable features of this protocol are its broad substrate scope, high reaction efficiency (up to 99 %) and enantioselectivity (up to 99 % ee), low catalyst loading (5 mol % of BINOL derivative), and mild reaction conditions.
N‐body computations using skeletal frameworks on multicore CPU/graphics processing unit architectures: an empirical performance evaluation
Authors: Goli Mehdi , González–Vélez Horacio 
Published: July 2013

SUMMARYWith the emergence of general‐purpose computation on graphics processing units, high‐level approaches that hide the conceptual complexity of the low‐level Compute Unified Device Architecture and Open Computing Language platforms are the subject of active research. However, these approaches may require a trade‐off in terms of achieved performance and utilisation on graphics processing units hardware and may impose algorithmic limitations. In this paper, we present and systematically evaluate the parallel performance of three implementations of the brute force, all‐pairs N‐body algorithm with skeletal deployments based on the FastFlow, SkePU and Thrust frameworks. Our results indicate that the skeletal framework implementation achieves up to two orders of magnitude speed‐up over serial version with a Tesla M2050 with lower implementation complexity than low‐level Compute Unified Device Architecture programming. Copyright © 2013 John Wiley & Sons, Ltd.
Energy efficiency of downlink packet scheduling in CoMP
Authors: Huq Kazi Mohammed Saidul , Mumtaz Shahid , Saghezchi Firooz B. , Rodriguez Jonathan , Aguiar Rui L. 
Published: July 2013

AbstractThe foreseen increase in the volume of mobile traffic and the correspondent increase in greenhouse gas emissions is now placing energy efficiency (EE) at the forefront of mobile network design. As a step towards incorporating more energy friendly mobile platforms in future networks, Third Generation Partnership Project Long‐Term Evolution (LTE)‐Advanced has adopted Coordinated Multi‐Point (CoMP) transmission/reception because of its ability to mitigate and/or coordinate inter‐cell interference. However, there is room for reducing energy consumption further by exploiting the inherent flexibility of dynamic resource allocation protocols. To this end packet scheduling schemes play a fundamental role in multi‐user scenarios and provide a potential research playground for optimising energy consumption in future networks. However, there is no effective benchmark in place for experimenting new design approaches. This paper provides a first attempt to analyse the Energy Efficiency of different downlink packet scheduling in CoMP for LTE networks using classical packet scheduling algorithm approaches such as Maximum Carrier to Interference ratio (MCI), Proportional Fairness (PF) and the Round Robin scheduling (RR), and provides some input to future comparison considerations. Copyright © 2013 John Wiley & Sons, Ltd.
Chewing problems are associated with depression in the elderly: results from the InCHIANTI study
Authors: Laudisio Alice , Milaneschi Yuri , Bandinelli Stefania , Gemma Antonella , Ferrucci Luigi , Incalzi Raffaele Antonelli 
Published: July 2013

ObjectiveDepression is increasingly recognized in older populations and associated with undernutrition, disability, and increased mortality. Chewing problems (CPs) share with depression these associations. The aim of the study was to evaluate the association, if any, between CPs and depression in older subjects.MethodsWe assessed 927 participants aged 65 years and older, derived from the ‘InCHIANTI’ study. Mood was evaluated using the CES‐D scale and defined depressed by a CES‐D score ≥20. CPs were self‐reported. Logistic regression was performed to assess the adjusted association between depression and CPs. The adjusted model was analyzed after stratifying for use of complete, partial dentures and edentulism.ResultsChewing problems were reported by 293/927 (31.6%) participants. Depression was present in 188/927(20.3%) participants. In multivariable logistic regression, CPs were associated with depression (OR = 1.81, 95% CI = 1.26–2.58; p = 0.001). No significant association was found among subjects who used complete dentures (OR = 1.12, 95% CI = 0.80–1.58, p = 0.515). Up to 27.8% of prevalent depression might be attributed to CPs.ConclusionsChewing problems are associated with depression in elderly population. Use of complete dentures hinder this association. Older depressed subjects should be screened for the presence of CPs; further studies are needed to evaluate the impact of early detection and correction of CPs on the development of depression. Copyright © 2013 John Wiley & Sons, Ltd.
Mutation frequency in 15 common cancer genes in high‐risk head and neck squamous cell carcinoma
Authors: McBride Sean M. , Rothenberg S. Michael , Faquin William C. , Chan Annie W. , Clark John R. , Ellisen Leif W. , Wirth Lori J. 
Published: July 2013

AbstractBackgroundWith prior studies having looked at unselected cohorts, we sought to explore the mutational landscape in a high‐risk group of head and neck squamous cell carcinoma (HNSCC) tumors.MethodsA multiplexed polymerase chain reaction (PCR) assay evaluating 68 loci in 15 genes was performed on 64 patients with high‐risk HNSCC. Because of the frequent PIK3CA and AKT1 mutations in patients with oropharyngeal carcinoma, we evaluated the relationship between mutation status and both clinical/pathologic variables and tumor control in this subgroup.ResultsSeventeen of 64 patients harbored mutations in the assayed loci: 16% in PIK3CA, 9% in TP53, 2% in AKT1, and 2% in epidermal growth factor receptor (EGFR). The frequency of PIK3CA/AKT1 mutations in oropharyngeal and sinonasal primaries was increased compared to other primary sites (35% vs 6%; p = .005). There was no relationship between mutation status and overall survival (OS), disease‐specific death, or progression in the oropharyngeal cohort.ConclusionWe identified frequent PIK3CA mutations in patients with high‐risk HNSCC confined predominantly to the oropharyngeal and sinonasal subsites; for the first time, mutation in AKT1 has been identified in HNSCC. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1181–1188, 2014
Cytoplasmic HuR expression: Correlation with cellular inhibitors of apoptosis protein‐2 expression and clinicopathologic factors in oral squamous cell carcinoma cells
Authors: Cha Jeong‐Dan , Kim Hee‐Kyeong , Cha In‐Ho 
Published: July 2013

ABSTRACTBackgroundHuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein‐2 (cIAP2) observed during tumorigenesis.MethodsTo assess the correlation between cIAP2 and HuR in cases of oral squamous cell carcinoma (OSCC), the expression patterns of HuR and cIAP2 were assessed by immunohistochemical analyses of 95 treated OSCC samples.ResultsIn the tumor tissues, positive cytoplasmic HuR expression was evident in 71.6% of samples and positive cIAP2 expression was noted in 95.8% of samples. Positive cytoplasmic HuR expression was significantly associated with positive cIAP2 (p < .035) and high cIAP2 expression (p < .007), as well as high grade (p < .050). The inhibition of HuR expression by small interfering RNA or leptomycin B caused a reduction in the inducibility of cIAP2 in oral cancer cells.ConclusionCytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1168–1175, 2014
Elastin Haploinsufficiency Impedes the Progression of Arterial Calcification in MGP-Deficient Mice
Authors: Khavandgar Zohreh , Roman Hassem , Li Jingjing , Lee Sara , Vali Hojatollah , Brinckmann Juergen , Davis Elaine C , Murshed Monzur 
Published: July 2013

ABSTRACT

Matrix gla protein (MGP) is a potent inhibitor of extracellular matrix (ECM) mineralization. MGP-deficiency in humans leads to Keutel syndrome, a rare genetic disease hallmarked by abnormal soft tissue calcification. MGP-deficient (Mgp–/–) mice show progressive deposition of hydroxyapatite minerals in the arterial walls and die within 2 months of age. The mechanism of antimineralization function of MGP is not fully understood. We examined the progression of vascular calcification and expression of several chondrogenic/osteogenic markers in the thoracic aortas of Mgp–/– mice at various ages. Although cells with chondrocyte-like morphology have been reported in the calcified aorta, our gene expression data indicate that chondrogenic/osteogenic markers are not upregulated in the arteries prior to the initiation of calcification. Interestingly, arterial calcification in Mgp–/– mice appears first in the elastic laminae. Considering the known mineral scaffolding function of elastin (ELN), a major elastic lamina protein, we hypothesize that elastin content in the laminae is a critical determinant for arterial calcification in Mgp–/– mice. To investigate this, we performed micro–computed tomography (µCT) and histological analyses of the aortas of Mgp–/–;Eln+/– mice and show that elastin haploinsufficiency significantly reduces arterial calcification in this strain. Our data suggest that MGP deficiency leads to alterations of vascular ECM that may in turn initiate arterial calcification. © 2014 American Society for Bone and Mineral Research.
Expression of Membrane Drug Efflux Transporters in the Sigmoid Colon of HIV‐Infected and Uninfected Men
Authors: De Rosa María Fabiana , Robillard Kevin R. , Kim Connie J. , Hoque Md. Tozammel , Kandel Gabor , Kovacs Colin , Kaul Rupert , Bendayan Reina 
Published: July 2013

AbstractThe use of antiretroviral therapy (ART) as pre‐exposure prophylaxis (PrEP) has gained global attention as a promising HIV prevention strategy in men who have sex with men. Permeability of these agents in the rectal mucosa may be partially regulated by interactions with drug efflux transporters, P‐glycoprotein (P‐gp), multidrug resistance‐associated proteins (MRPs) and/or breast cancer resistance protein (BCRP). The objective of this work was to investigate the expression of drug efflux transporters in recto‐sigmoid colon tissues of HIV‐infected and uninfected men, and evaluate the association of ART and/or HIV infection with drug transporter expression. MDR1/P‐gp, MRPs (1–4) and BCRP mRNA and protein expression were detected in sigmoid colon biopsies of HIV‐uninfected individuals. Biopsies from HIV‐infected, ART‐naïve participants revealed a significant downregulation of P‐gp and MRP2 protein levels compared to HIV‐uninfected individuals. Biopsies from HIV‐infected ART‐treated patients showed 1.9‐fold higher P‐gp protein expression and 1.5‐fold higher MRP2 protein expression compared to the ones obtained from the HIV‐infected ART‐naïve patients. This is a first report demonstrating that HIV infection or ART could alter expression of drug efflux transporters in gut mucosa which in turn could affect the permeability of PrEP antiretroviral agents across this barrier, a highly vulnerable site of HIV transmission.
Founding an adverse drug reaction (ADR) network: A method for improving doctors spontaneous ADR reporting in a general hospital
Authors: Goldstein Lee Hilary , Berlin Maya , Saliba Walid , Elias Mazen , Berkovitch Matitiyahu 
Published: July 2013

AbstractAdverse drug reactions (ADR) are underreported by doctors despite numerous efforts. We aimed to determine if establishing an “ADR reporting doctor's network” within a hospital would increase the quantity of ADRs reported by hospital doctors. One hundred hospital doctors joined the network. Email reminders were sent to network members during the 1 year study period, conveying information about ADRs reported, amusingly and pleasantly reminding them to report ADRs in minimal detail, by phone, email, text message or mail to the Clinical Pharmacology Unit, who would further complete the report. A total of 114 ADRs were reported during the study period in comparison to 48, 26, and 17 in the previous 3 years (2008, 2009, 2010, respectively). In the 3 years prior, doctors reported 41.7% of the reported ADRs whereas in the study period, doctors reported 74.3% of ADRs (P < .001), reflecting an 80% increase in doctors reports. Ninety seven percent of doctors' reports were of ADR network members. Thirty‐four (34%) network members reported an ADR during the study period and 31 of the 34 reporters had never reported ADRs before becoming network members. Establishing an ADR network of doctors substantially increases ADR reporting amongst its members.
Extracting source characteristics and dynamics of the August 2010 Mount Meager landslide from broadband seismograms
Authors: Allstadt Kate 
Published: July 2013

AbstractSeismic methods can substantially improve the characterization of the dynamics of large and rapid landslides. Such landslides often generate strong long‐period seismic waves due to the large‐scale acceleration of the entire landslide mass, which, according to theory, can be approximated as a single‐force mechanism at long wavelengths. I apply this theory and invert the long‐period seismic waves generated by the 48.5 Mm3 August 2010 Mount Meager rockslide‐debris flow in British Columbia. Using data from five broadband seismic stations 70 to 276 km from the source, I obtain a time series of forces the landslide exerted on the Earth, with peak forces of 1.0 × 1011 N. The direction and amplitude of the forces can be used to determine the timing and occurrence of events and subevents. Using this result, in combination with other field and geospatial evidence, I calculate an average horizontal acceleration of the rockslide of 0.39 m/s2 and an average apparent coefficient of basal friction of 0.38 ± 0.02, which suggests elevated basal fluid pressures. The direction and timing of the strongest forces are consistent with the centripetal acceleration of the debris flow around corners in its path. I use this correlation to estimate speeds, which peak at 92 m/s. This study demonstrates that the time series recording of forces exerted by a large and rapid landslide derived remotely from seismic records can be used to tie post‐slide evidence to what actually occurred during the event and can serve to validate numerical models and theoretical methods.
Database of normal japanese gray matter volumes in the default mode network
Authors: Goto Masami , Abe Osamu , Aoki Shigeki , Takao Hidemasa , Hayashi Naoto , Miyati Tosiaki , Mori Harushi , Kunimatsu Akira , Ino Kenji , Yano Keiichi , Ohtomo Kuni 
Published: July 2013

PurposeTo show the gray matter volumes in the default mode network (DMN) using the atlas‐based method and to evaluate age‐related volume change in the DMN region. Estimation of gray matter volumes is interesting research because previous reports showed an association with gray matter volume (GMV) and diseases.Materials and MethodsWe focused on five nodes of the DMN (posterior cingulate, precuneus, lateral temporal cortex [LTC], medial prefrontal cortex, and inferior parietal lobule). In all, 1122 healthy adults were included in the present study. T1‐weighted magnetic resonance (MR) images were obtained using a 3T‐MR scanner. To investigate GMV in the DMN, segmented gray matter images were measured by the atlas‐based method, using Statistical Parametric Mapping 5. Volumes were expressed using three different methods: region of interest (ROI)‐volume (mL), the volume itself; ROI‐TIV (%), as a percentage of total intracranial volume (individual difference of head size is corrected); and ROI‐GMV (%), as a percentage of gray matter volume (individual difference of atrophy speed for aging is corrected).ResultsNegative correlations between measurement values on ROI and age were observed in all five ROIs of the DMN region by two measures of volume (ROI‐volume (mL) and ROI‐TIV (%)), in both genders. In contrast, positive correlations between measurement values on ROI and age were observed in the posterior cingulate and LTC with ROI‐GMV (%), in both genders.ConclusionThe present study is the first report about volume change in the DMN that includes age‐related effects. J. Magn. Reson. Imaging 2014;39:132–142. © 2013 Wiley Periodicals, Inc.
Optimization of direct modulation rate for circular microlasers by adjusting mode Q factor
Authors: Lv Xiao‐Meng , Huang Yong‐Zhen , Zou Ling‐Xiu , Long Heng , Du Yun 
Published: July 2013

AbstractSemiconductor microcircular lasers have been investigated as potential light sources for photonic integrated circuits and optical interconnections for more than two decades. However, the direct modulation bandwidths of the circular microlasers remain a challenge, especially when being compared with other microlasers, such as photonic crystal lasers. In this paper, microcircular lasers connected to an output waveguide are investigated for high‐speed direct modulation with optimized mode Q factors. Small signal modulation with a resonance frequency of fR = 12.5 GHz is realized for a AlGaInAs/InP circular microlaser with a radius of 10 µm at 290 K. Furthermore, clear eye diagrams are observed at 12.5 Gbit/s for a 15‐µm radius circular microlaser with fR = 6.9 GHz.
Susceptibility weighted imaging of cartilage canals in porcine epiphyseal growth cartilage ex vivo and in vivo
Authors: Nissi Mikko J. , Toth Ferenc , Zhang Jinjin , Schmitter Sebastian , Benson Michael , Carlson Cathy S. , Ellermann Jutta M. 
Published: July 2013

PurposeHigh‐resolution visualization of cartilage canals has been restricted to histological methods and contrast‐enhanced imaging. In this study, the feasibility of non‐contrast‐enhanced susceptibility weighted imaging (SWI) for visualization of the cartilage canals was investigated ex vivo at 9.4 T, further explored at 7 and 3 T and demonstrated in vivo at 7 T, using a porcine animal model.MethodsSWI scans of specimens of distal femur and humerus from 1 to 8 week‐old piglets were conducted at 9.4 T using 3D‐GRE sequence and SWI post‐processing. The stifle joints of a 2‐week old piglet were scanned ex vivo at 7 and 3 T. Finally, the same sites of a 3‐week‐old piglet were scanned, in vivo, at 7 T under general anesthesia using the vendor‐provided sequences.ResultsHigh‐contrast visualization of the cartilage canals was obtained ex vivo, especially at higher field strengths; the results were confirmed histologically. In vivo feasibility was demonstrated at 7 T and comparison of ex vivo scans at 3 and 7 T indicated feasibility of using SWI at 3 T.ConclusionsHigh‐resolution 3D visualization of cartilage canals was demonstrated using SWI. This demonstration of fully noninvasive visualization opens new avenues to explore skeletal maturation and the role of vascular supply for diseases such as osteochondrosis. Magn Reson Med 71:2197–2205, 2014. © 2013 Wiley Periodicals, Inc.