bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between composite dietary antioxidant index and stroke among individuals with diabetes
Authors: Zhang Hong-Qiang , Shi Jie , Yue Tong , Weng Jia-Hao , Wang Xu-Lin , Wang Hao , Su Xiao-Yu , Zheng Xue-Ying , Luo Si-Hui , Ding Yu , Wang Chao-Fan 
Published: July 2024

BACKGROUND
Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions, such as cardiovascular diseases and stroke. The composite dietary antioxidant index (CDAI), which reflects the overall intake of key dietary antioxidants, has been identified as a crucial metric for exploring this relationship. Although previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals, there remains a substantial gap in understanding this association among individuals with dia-betes, who are at an inherently greater risk for cerebrovascular events.
AIM
To investigate the association between CDAI and stroke risk in individuals with diabetes.
METHODS
Using a cross-sectional study design, this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with diabetes. The CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants: Vitamins A, C, and E; carotenoids; selenium; and zinc. Multivariate logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke risk.
RESULTS
The participant cohort, with an average age of 59.5 years and a slight male majority, reflected the broader demographic characteristics of individuals with diabetes. The analysis revealed a strong inverse relationship between CDAI levels and stroke risk. Remarkably, those in the highest quintile of CDAI demonstrated a 43% lower prevalence of stroke compared to those in the lowest quintile, even after adjustments for various confounders. This finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with diabetes.
CONCLUSION
Our findings suggested that CDAI was inversely associated with stroke prevalence among patients with diabetes. These results suggest incorporating antioxidant-rich foods into dietary regimens as a potential strategy for stroke prevention.
Intestinal glucagon-like peptide-1: A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice
Authors: Jin Fang-Xin , Wang Yan , Li Min-Ne , Li Ru-Jiang , Guo Jun-Tang 
Published: July 2024

BACKGROUND
Impaired hypoglycaemic counterregulation has emerged as a critical concern for diabetic patients who may be hesitant to medically lower their blood glucose levels due to the fear of potential hypoglycaemic reactions. However, the patho-genesis of hypoglycaemic counterregulation is still unclear. Glucagon-like peptide-1 (GLP-1) and its analogues have been used as adjunctive therapies for type 1 diabetes mellitus (T1DM). The role of GLP-1 in counterregulatory dys-function during hypoglycaemia in patients with T1DM has not been reported.
AIM
To explore the impact of intestinal GLP-1 on impaired hypoglycaemic counterregulation in type 1 diabetic mice.
METHODS
T1DM was induced in C57BL/6J mice using streptozotocin, followed by intraperitoneal insulin injections to create T1DM models with either a single episode of hypoglycaemia or recurrent episodes of hypoglycaemia (DH5). Immunofluorescence, Western blot, and enzyme-linked immunosorbent assay were employed to evaluate the influence of intestinal GLP-1 on the sympathetic-adrenal reflex and glucagon (GCG) secretion. The GLP-1 receptor agonist GLP-1(7-36) or the antagonist exendin (9-39) were infused into the terminal ileum or injected intraperitoneally to further investigate the role of intestinal GLP-1 in hypoglycaemic counterregulation in the model mice.
RESULTS
The expression levels of intestinal GLP-1 and its receptor (GLP-1R) were significantly increased in DH5 mice. Consecutive instances of excess of intestinal GLP-1 weakens the sympathetic-adrenal reflex, leading to dysfunction of adrenal counterregulation during hypoglycaemia. DH5 mice showed increased pancreatic δ-cell mass, cAMP levels in δ cells, and plasma somatostatin concentrations, while cAMP levels in pancreatic α cells and plasma GCG levels decreased. Furthermore, GLP-1R expression in islet cells and plasma active GLP-1 levels were significantly increased in the DH5 group. Further experiments involving terminal ileal infusion and intraperitoneal injection in the model mice demonstrated that intestinal GLP-1 during recurrent hypoglycaemia hindered the secretion of the counterregulatory hormone GCG via the endocrine pathway.
CONCLUSION
Excessive intestinal GLP-1 is strongly associated with impaired counterregulatory responses to hypoglycaemia, leading to reduced appetite and compromised secretion of adrenaline, noradrenaline, and GCG during hypo-glycaemia.
Circulating glycated albumin levels and gestational diabetes mellitus
Authors: Xiong Wei , Zeng Zhao-Hui , Xu Yuan , Li Hui , Lin Hui 
Published: July 2024

BACKGROUND
Gestational diabetes mellitus (GDM) is characterized by glucose intolerance that is first diagnosed during pregnancy, making it the most common complication associated with this period. Early detection and targeted treatment of GDM can minimize foetal exposure to maternal hyperglycaemia and subsequently reduce the associated adverse pregnancy outcomes. Previous studies have inconsistently suggested that the level of glycated albumin (GA) might predict GDM.
AIM
To review and synthesize existing evidence to evaluate the relationship between GA levels and the development of GDM.
METHODS
We sought to compare GA levels between GDM and control groups in this meta-analysis by systematically searching the Web of Science, PubMed, Cochrane Library, and Embase databases for articles published up to June 2023. The analysis utilized the weighted mean difference (WMD) as the primary metric. The data were meticulously extracted, and the quality of the included studies was assessed. Additionally, we conducted a subgroup analysis based on study region and sample size. We assessed heterogeneity using I 2 statistics and evaluated publication bias through funnel plots. Additionally, trim-and-fill analysis was employed to detect and address any potential publication bias.
RESULTS
The meta-analysis included a total of 11 studies involving 5477 participants, comprising 1900 patients with GDM and 3577 control individuals. The synthesized results revealed a notable correlation between elevated GA levels and increased susceptibility to GDM. The calculated WMD was 0.42, with a 95% confidence interval (95%CI) ranging from 0.11 to 0.74, yielding a P value less than 0.001. Concerning specific GA levels, the mean GA level in the GDM group was 12.6, while for the control group, it was lower, at 11.6. This discrepancy underscores the potential of GA as a biomarker for assessing GDM risk. Moreover, we explored the levels of glycated haemoglobin (HbA1c) in both cohorts. The WMD for HbA1c was 0.19, with a 95%CI ranging from 0.15 to 0.22 and a P value less than 0.001. This observation suggested that both GA and HbA1c levels were elevated in individuals in the GDM group compared to those in the control group.
CONCLUSION
Our meta-analysis revealed a substantial correlation between elevated GA levels and increased GDM risk. Furthermore, our findings revealed elevated levels of HbA1c in GDM patients, emphasizing the significance of monitoring both GA and HbA1c levels for early GDM detection and effective management.
Transient diabetes mellitus with ABCC8 variant successfully treated with sulfonylurea: Two case reports and review of literature
Authors: Shen Ling-Hua , Cui Yan , Fu Dong-Xia , Yang Wei , Wu Sheng-Nan , Wang Hui-Zhen , Yang Hai-Hua , Chen Yong-Xing , Wei Hai-Yan 
Published: July 2024

BACKGROUND
Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes mellitus that usually presents within the first 6 mo of life. Patients often enter remission within several months, although relapse can occur later in life. Mutations in the ABCC8 gene, which encodes the sulfonylurea receptor 1 of the ATP-sensitive potassium channel in pancreatic beta cells, are associated with TNDM and permanent neonatal diabetes. This study describes a novel de novo c.3880C>T heterozygous ABCC8 variant that causes TNDM and can be treated with sulf-onylurea therapy.
CASE SUMMARY
We retrospectively analyzed 2 Chinese patients with TNDM who were diagnosed, treated, or referred for follow-up between September 2017 and September 2023. The patients were tested for mutations using targeted next-generation sequencing. Patients with neonatal diabetes mellitus caused by a c.3880C>T heterozygous missense variant in the ABCC8 gene have not been reported before. Both children had an onset of post-infectious diabetic ketoacidosis, which is worth noting. At a follow-up visit after discontinuing insulin injection, oral glyburide was found to be effective with no adverse reactions.
CONCLUSION
Early genetic testing of neonatal diabetes mellitus aids in accurate diagnosis and treatment and helps avoid daily insulin injections that may cause pain.
Covid-19 Vaccine: A Qualitative Study On Perception And Acceptability Among Staff Of The University Of Calabar, Calabar, Nigeria.
Authors: Festus Nkpoyen , Anastasia Isika , Patience Odusulu , Esther Macauley , Aniekan Etokidem 
Published: July 2024

The study assessed the perception and acceptability of COVID-19 vaccine among staff of the University of Calabar, Calabar, Nigeria. The COVID-19 pandemic has been reported in all countries of the world with 703,850,963 cases and 7,003,395 deaths and significant adverse health and socio-economic consequences. This qualitative study used seven Focus Group Discussions (FGDs), two Key Informant Interviews (KIIs) and one In-depth Interview (IDI). The study was conducted among both the teaching and non-teaching staff of the University of Calabar. Positive and negative perceptions of the vaccine were recorded. Religion exerted both negative and positive effect on perception and acceptability. Alleged intimidation by the government, other employers of labour and school authorities also affected acceptability. Other barriers to the uptake of the vaccine included: fear of contacting the virus while accessing vaccination, health system barriers such as misinformation from healthcare providers, out-of-stock syndrome, corrupt practices of healthcare providers who would issue the vaccination card to someone who had not actually been vaccinated, distrust in government; also, culture and myths and misconceptions. The findings may provide information for the government, Civil Society Organisations (CSOs) and other stakeholders to promote knowledge and positive perceptions through behaviour change communication regarding COVID-19 vaccine. Attitudinal orientation and reorientation of healthcare providers could address some of the health system barriers associated with poor perception and low acceptability of the vaccine.
ACKNOWLEDGEMENT of funding source: The funding for this research was provided by the Tertiary Education Trust Fund (TETfund) under its Institution Based Research (IBR) Fund.
A Comparative Study of Green and Conventional Synthesis of Schiff Base And its Metal Complexes from 3, 5-Dichloro Aniline And 3-Chloro-4 Fluroaniline
Authors: Shailakshi  , Rosmi Tees  , Gloria D'souza  , Dr Sapna kumari M  , Dr Geetha M Pinto  , Priya  
Published: July 2024

The new Schiff base ligand (E)-N-(3, 5-dichlorophenyl)-1-(3, 4-dimethoxyphenyl) methanimine (L1) was prepared through condensation reaction of 3,5-Dichloroaniline and 3-Chloro-4- Fluroaniline in 1:1 molar ratio using conventional and green method. The new ligand was characterised by elemental analysis and spectral techniques. The coordination behavior of a transition metal ions Ni(II) with the newly prepared schiff base is reported . The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analysis, FTIR, , 1H NMR, 13C NMR. Comparison between the two methods and the yield results prove that green method is more efficient and requires less reaction time than conventional method. The synthesized ligand and its complexes were screened for antimicrobial activities. The complexes were found to possess high biological activities against different organisms.
Verificação e estudo de metodologias para a determinação de metas para indicadores produtivos
Authors: Silva Fabiano Della Libera da , Spala Saulo Tuayar 
Published: July 2024

Este trabalho revisa a literatura sobre indicadores-chave de processo (KPIs), abordando seus conceitos, importância, valor estratégico para as organizações e sua aplicação prática como ferramentas essenciais para a tomada de decisões de negócios. Enfatiza a relevância dos indicadores de desempenho, especialmente KPIs, definindo-os globalmente e considerando as peculiaridades dos diferentes setores. Enfatiza a importância de definir metas ambiciosas, mas alcançáveis, e alinhá-las com os objetivos estratégicos da organização, garantindo a sua implementação em todos os níveis do negócio. Foi utilizado o método multicritério Methodi Ordinatio, resultando na seleção de 11 artigos relevantes para análise sistemática, apoiando o estudo. A análise dos trabalhos mais importantes sobre indicadores mostra a consciência da importância dos KPIs na medição e monitoramento dos processos organizacionais. O trabalho está estruturado da seguinte forma: introdução do tema (parte 1), fundamentação teórica (parte 2), abordagem metodológica (parte 3), resultados e discussão (parte 4).
Awareness of Cancer and Cancer Risk Factors among Women in Kitale Municipality
Authors: Makunja Sostine , Aluoch Joash , Ngugi Caroline 
Published: July 2024

Purpose: The aim of the study was to assess awareness of cancer and cancer risk factors among women in Kitale Municipality
Methodology: A cross-sectional study using stratified simple sampling to select a sample of 422 women aged 30-69 years old was adopted. A Structured questionnaire was used to collect data. Data entry and coding was done in SPSS v20. Subsequent content analysis was used to descriptively summarize and compute proportions, mean and standard deviation in reporting socio-demographic data. To test the association between dependent and independent variables, Chi-square was used while Multiple Logistic Regression analysis was used to generate adjusted odds ratios of association. Data was presented in form of tables and figures.
Findings: Findings suggest that 80% (338) women were aware of cervical cancer. Among them, 75% (317) had never heard of Human Papilloma Virus HPV while only 23% (97) women knew HPV infection was a risk factor for developing cervical cancer. There was a positive association between awareness of multiple sexual partners (p=0.007); early sexual intercourse (p=0.012) as risk factors and cervical cancer screening. This study found that there was modest awareness about cervical cancer among women in this Municipality.
Unique Contribution to Theory, Practice and Policy: The study recommends scale up for cervical cancer awareness by stakeholders. The current study has added knowledge that will be used by stakeholders advocating for cervical cancer awareness that will aid in uptake important in early detection and treatment of cervical cancer cases, and hence reducing case morbidity and mortality.
PENERAPAN METODE TECHNIQUE FOR OTHERSREFRENCES BY SIMILLARITY TO IDEAL SOLUTION (TOPSIS) UNTUK PENENTUAN PEMBIAYAAN ULANG PADA PT.FIF GROUP CABANG KOTABUMI
Authors: Plaza R M. Abu Jihad , Wibowo Adi , Wijaya Ryan Aji 
Published: July 2024

Persaingan dunia usaha yang ketat maka perusahaan harus pintar-pintar melihat peluang dan kebutuhan masyarakat, sehingga perusahaan mengeluarkan program Pembiayaan Ulang untuk para konsumen yang ingin menjaminkan kendaraannya dan pembayaran kendaraan tersebut dilakukan secara cicilan. Dalam penentuan pemberian Pembiayaan Ulang masih mengutamakan analisis karyawan yang diberi tugas dalam mensurvei kondisi konsumen yang akan mengajukan Pembiayaan Ulang pada FIF Group Kotabumi, sehingga dalam penentuan penerima kredit terkadang tidak objektif sehingga sering terjadi kredit macet yang menghambat perputaran uang pada FIF Group Kotabumi.

Sistem Pendukung Keputusan (SPK) merupakan salah satu solusi perusahaan yang membantu melakukan pengambilan keputusan terhadap konsumen layak atau tidak layak menerima pembiayaan pembiayaan ulang. Dibutuhkan suatu metode perhitungan yang digunakan untuk menyelesaikan permasalahan dengan banyak kriteria. Salah satu metode perhitungan yang digunakan adalah Metode Technique for Others Refrences by Simillarity to Ideal Solution (TOPSIS). Konsep dasar dari metode TOPSIS yang didasarkan pada konsep bahwa alternatif terbaik tidak hanya memiliki jarak terpendek dari solusi ideal positif tetapi juga memiliki jarak terjauh dari solusi ideal negatif.

Hasil dari sistem pendukung keputusanyang dibangun ini dapat menghasilkan keputusan yang lebih objektif. Menghasilkan 6 nasabah diterima dan 4 nasabah ditolak yang dapat digunakan sebagai rekomendasi penentuan kepada PT. FIF Group Cabang Kotabumi.
DAMPAK PENGELUARAN PEMERINTAH DAN PEMBAYARAN NON-TUNAI SELAMA PANDEMI COVID-19 TERHADAP INFLASI DI INDONESIA
Authors: Siswantoro Siswantoro 
Published: July 2024

Laju inflasi tercatat di bawah 2% pada dua periode pertama pandemi (2020-2021), seiring dengan melemahnya jumlah permintaan, namun pada periode ketiga pandemi (2022), laju inflasi meningkat menjadi lebih dari 5%. Untuk mengendalikan laju inflasi selama pandemi, pemerintah telah menerapkan kebijakan fiskal seperti mengatur jumlah pengeluaran negara dan menjalankan akselerasi pembayaran non-tunai. Tujuan penelitian ini adalah untuk menguji dampak pengeluaran pemerintah, pembayaran non-tunai, dan konsumsi masyarakat terhadap tingkat inflasi di Indonesia. Sebanyak 99 data panel yang terdiri dari 33 provinsi dengan periode 3 tahun (2020-2022) dianalisis dengan menggunakan fixed effect model. Hasil penelitian menunjukkan bahwa pengeluaran pemerintah berpengaruh negatif dan signifikan terhadap inflasi, sementara konsumsi masyarakat berpengaruh positif dan signifikan terhadap inflasi. Pembayaran non-tunai dalam bentuk kartu debit dan e-money berpengaruh positif dan signifikan terhadap inflasi, sementara kartu kredit tidak berpengaruh signifikan terhadap inflasi. Penulis menyarankan untuk merinci variabel pengeluaran pemerintah untuk mendapatkan hasil yang lebih detail dan mengkombinasikan penelitian kualitatif.
SIMPLE AND LOW-COST SYNTHESIS OF LI2FESIO4 CATHODE MATERIALS BY MECHANICAL ACTIVATION USING A Fe3+ PRECURSOR
Authors: Jaén Juan Antonio , Mendoza Ian , Chung Eduardo 
Published: July 2024

An easy and low-cost synthesis of monoclinic Li2FeSiO4 based on a carbothermal process and a short-time preliminary milling of a reactant mixture in a planetary mill was investigated. Monoclinic Li2FeSiO4/C is prepared using Fe3+ (Fe2O3) as a precursor. For this purpose, commercial hematite and one obtained through a green route were used. This material is studied and compared with Li2FeSiO4 obtained using Fe2+ (FeC2O4·2H2O) as a precursor. In all cases, citric acid was used as a reducing agent and as an in situ conductive additive. Mössbauer spectroscopy was used as the central technique in this study.
PROSPECCIÓN CON SERPIENTES EN CUATRO DISTRITOS DE LA PROVINCIA DE CHIRIQUÍ CON APLICACIÓN DEL SISTEMA DE INFORMACIÓN GEOGRÁFICA (SIG)
Authors: Prado Marcelo Mack , Martínez Víctor , Araúz Arsenio , Herrera L. Kathania 
Published: July 2024

Este estudio se centra en evaluar la diversidad de serpientes en los Distritos de Alanje, Bugaba, Boquerón y Renacimiento, en la provincia de Chiriquí, República de Panamá, considerando las influencias antropogénicas en los microhábitats. Además, abordamos la relación entre las fragmentaciones de los hábitats y la biodiversidad de serpientes, destacando la importancia de comprender el impacto humano en estas comunidades.
El muestreo lo desarrollamos a lo largo de dos años en las estaciones seca, lluviosa y las transiciones entre ambas, evaluando de forma aleatoria las áreas. Los 82 ejemplares pertenecen a 6 familias, siendo Colubridae y Viperidae las más representadas.
La proporción de especies no venenosas y venenosas fue de 7:4, resultando una prevalencia de las primeras. La curva de acumulación de especies sugiere que se alcanzó la saturación de especies al muestrear aproximadamente 50 ejemplares. Los resultados reflejan alta diversidad de serpientes en la región, con índices de biodiversidad que respaldan la variación en los hábitats prospectados.
La abundancia de especies como Bothrops asper es la de mayor peligro para la salud humana, así como la identificación de especies vulnerables resaltan la importancia de su conservación.
Los resultados proporcionan una visión adecuada de la diversidad de serpientes en los Distritos prospectados y demuestran la necesidad de continuar monitoreando y conservando estas poblaciones en el contexto de cambios ambientales y antropogénicos.
La intervención arqueológica en la muralla tardoantigua de Talavera de la Reina (Toledo): sector de El Salvador. Un conjunto cerámico preislámico y emiral
Authors: Retuerce Velasco Manuel , García García Luis Alejandro 
Published: July 2024

Se presenta un conjunto cerrado de materiales cerámicos, que, aparte de los romanos y tardoantiguos y de época visigoda —también presentes en él—, en su mayoría, son de cronología emiral (fines del siglo IX). Dicho conjunto fue encontrado en la intervención arqueológica desarrollada en el sector de El Salvador del primer recinto amurallado de Talavera de la Reina (Toledo). Un recinto éste que en estos trabajos se ha demostrado que posee una cronología tardoantigua del siglo IV-V d.C, muy anterior a lo que hasta el momento generalmente se había defendido, pues se le había considerado como islámico.
Globalisation in the perspective of Polish media landscape: Case studies of NK.pl vs Facebook.com and Allegro.pl vs Amazon.com
Authors: Durmaj Małgorzata 
Published: July 2024

The author focuses on presenting the phenomenon of globalisation in the context of Polish social media and e-commerce markets. The main objective is to find correlations between the deactivation of the Polish social network NK.pl (Nasza-klasa.pl; eng. Our-class.pl) vs. the development of globalisation, as well as the maintenance of the leading position by the online sales platform Allegro vs. the partial “failure” of the examined phenomenon. The considerations, embedded in broader theoretical inquiries, are conducted on the basis of case studies, a literature review, and desk research. The paper refers to the Polish online media environment. The author focuses on the cases of NK.pl vs. Facebook and Allegro vs. Amazon. The results indicate that globalisation is not “universal” in the media sphere in Poland. The author characterises the factors that influence the scope of impact of global solutions in the local market. In the paper, the author also draws attention to the importance of preserving brand identity, following the expectations and habits of the audience group and promoting culture, all of which can contribute to maintaining a robust position in the industry. The article is significant due to the continuous development of globalisation processes and the search by local companies for strategies to compete with global giants.