bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multifactorial approach to war and corruption metaphors in South Asian Englishes
Authors: Garlepow Linnea , Funke Nina , Güldenring Barbara Ann 
Published: July 2024

AbstractThe present paper provides a corpus‐based study of war and corruption metaphors in South Asian Englishes (specifically Indian English, Bangladeshi English, Nepali English and Pakistani English). Considering the highly news‐relevant nature of these concepts, the South Asian Varieties of English corpus (SAVE2020) serves as the database. In an initial step, we outline the source domains at different levels of schematicity used to construe war and corruption, revealing the salient domains at location and person. By pursuing a multifactorial approach, this study aims at answering the question whether the choice of source domain is governed by the sociolinguistic factors gender and variety, and intra‐linguistic factors, for example, length and semantic prosody of the metaphor‐related words. It furthermore investigates whether multifactorial analyses, which are still a novelty within research on metaphor variation, constitute a suitable methodological approach. By doing so, our research demonstrates the need to complement this quantitative approach with a qualitative one that offers a more fine‐grained description of the source domains used to structure metaphorical concepts like war and corruption.
Thermal Runaway Characteristics of Ni-Rich Lithium-Ion Batteries Employing Triphenyl Phosphate-Based Electrolytes
Authors: Gao Zhenhai , Rao Shun , Wang Yupeng , Xiao Yang , Li Weifeng , Zhang Zien , Yuan Quan 
Published: July 2024

Abstract
Enhancing the safety performance of high-energy-density lithium-ion batteries is crucial for their widespread adoption. Herein, a cost-effective and highly efficient electrolyte additive, triphenyl phosphate (TPP), demonstrates flame-retardant properties by scavenging hydrogen radicals in the flame, thereby inhibiting chain reactions and flame propagation to enhance the safety performance of graphite/LiNi0.8Co0.1Mn0.1O2 (Gr/NCM811) pouch cells. The results reveal that the capacity retention of cells without flame retardants, and those with the addition of 1 wt%, 3 wt%, 5 wt%, and 10 wt% TPP is 96.4%, 92.1%, 84.15%, 40.8%, and 12.4% (at 1/2C 300 cycles), respectively. Furthermore, compared to cells without flame retardants, the highest temperature during thermal runaway (TR) decreases by 8.3%, 26.9%, 35.1%, and 38.8% with the addition of 1 wt%, 3 wt%, 5 wt%, and 10 wt% TPP, respectively. Through comprehensive analysis of the impact of flame-retardant additives on battery electrochemical performance and safety, it is determined that the optimal addition amount is 3 wt%. At this level, there are no significant flames during battery abuse, the triggering temperature for TR increases by 26.6 ℃, and the maximum temperature decreases by 157 ℃. Moreover, even after 300 cycles at 1/2C, a capacity of 814.5 mAh is retained, with a capacity retention rate of 84.1%. This study provides valuable insights into mitigating TR in high-energy-density power batteries.
Population pharmacokinetics of rifabutin among HIV/TB co-infected children on lopinavir/ritonavir-based antiretroviral therapy
Authors: Semere Gebreyesus Manna , Wasmann Roeland E. , McIlleron Helen , Oladokun Regina , Okonkwo Prosper , Wiesner Lubbe , Denti Paolo , Rawizza Holly E. 
Published: July 2024

ABSTRACT

In adults requiring protease inhibitor (PI)-based antiretroviral therapy (ART), replacing rifampicin with rifabutin is a preferred option, but there is lack of evidence to guide rifabutin dosing in children, especially with PIs. We aimed to characterize the population pharmacokinetics of rifabutin and 25-O-desacetyl rifabutin (des-rifabutin) in children and optimize its dose. We included children from three age cohorts: (i) <1-year-old cohort and (ii) 1- to 3-year-old cohort, who were ART naïve and received 15- to 20-mg/kg/day rifabutin for 2 weeks followed by lopinavir/ritonavir (LPV/r)-based ART with 5.0- or 2.5 mg/kg/day rifabutin, respectively, while the (iii) >3-year-old cohort was ART-experienced and received 2.5-mg/kg/day rifabutin with LPV/r-based ART. Non-linear mixed-effects modeling was used to interpret the data. Monte Carlo simulations were performed to evaluate the study doses and optimize dosing using harmonized weight bands. Twenty-eight children were included, with a median age of 10 (range 0.67–15.0) years, a median weight of 11 (range 4.5–45) kg, and a median weight-for-age
z
score of −3.33 (range −5.15 to −1.32). A two-compartment disposition model, scaled allometrically by weight, was developed for rifabutin and des-rifabutin. LPV/r increased rifabutin bioavailability by 158% (95% confidence interval: 93.2%–246.0%) and reduced des-rifabutin clearance by 76.6% (74.4%–78.3%). Severely underweight children showed 26% (17.9%–33.7%) lower bioavailability. Compared to adult exposures, simulations resulted in higher median steady-state rifabutin and des-rifabutin exposures in 6–20 kg during tuberculosis-only treatment with 20 mg/kg/day. During LPV/r co-treatment, the 2.5-mg/kg/day dose achieved similar exposures to adults, while the 5-mg/kg/day dose resulted in higher exposures in children >7 kg. All study doses maintained a median
C
max
of <900 µg/L. The suggested weight-band dosing matches adult exposures consistently across weights and simplifies dosing.
Case Commentary: Extending our therapeutic range against multidrug-resistant
Candida
Authors: Adelman Max W. , Andes David R. 
Published: July 2024

ABSTRACT

Deep-seated
Candida
spp. infections may necessitate extended durations of antifungal therapy. Increasing resistance to first-line antifungals threatens the most common options for long-term treatment. In this issue, Ponta et al. (Antimicrob Agents Chemother 68:e00750-24, 2024,
https://doi.org/10.1128/aac.00750-24
) present cases in which they used rezafungin, a novel long-acting echinocandin antifungal, for extended durations. While excellent clinical evidence supports the short-term safety of rezafungin, these cases demonstrate that rezafungin may additionally have a role in long-term suppressive therapy for antifungal-resistant
Candida
spp. infections.
A natural ANI gap that can define intra-species units of bacteriophages and other viruses
Authors: Aldeguer-Riquelme Borja , Conrad Roth E. , Antón Josefa , Rossello-Mora Ramon , Konstantinidis Konstantinos T. 
Published: July 2024

ABSTRACT

Despite the importance of intra-species variants of viruses for causing disease and/or disrupting ecosystem functioning, there is no universally applicable standard to define these. A (natural) gap in whole-genome average nucleotide identity (ANI) values around 95% is commonly used to define species, especially for bacteriophages, but whether a similar gap exists within species that can be used to define intra-species units has not been evaluated yet. Whole-genome comparisons among members of 1,016 bacteriophage (
Caudoviricetes
) species revealed a region of low frequency of ANI values around 99.2%–99.8%, showing threefold or fewer pairs than expected for an even distribution. This second gap is prevalent in viruses infecting various cultured or uncultured hosts from a variety of environments, although a few exceptions to this pattern were also observed (3.7% of total species) and are likely attributed to cultivation biases or other factors. Similar results were observed for a limited set of eukaryotic viruses that are adequately sampled, including SARS-CoV-2, whose ANI-based clusters matched well with the WHO-defined variants of concern, indicating that our findings from bacteriophages might be more broadly applicable and the ANI-based clusters may represent functionally and/or ecologically distinct units. These units appear to be predominantly driven by (high) ecological cohesiveness coupled to either frequent recombination for bacteriophages or selection and clonal evolution for other viruses such as SARS-CoV-2, indicating that fundamentally different underlying mechanisms could lead to similar diversity patterns. Accordingly, we propose the ANI gap approach outlined above for defining viral intra-species units, for which we propose the term genomovars.

IMPORTANCE
Viral species are composed of an ensemble of intra-species variants whose individual dynamics may have major implications for human and animal health and/or ecosystem functioning. However, the lack of universally accepted standards to define these intra-species variants has led researchers to use different approaches for this task, creating inconsistent intra-species units across different viral families and confusion in communication. By comparing hundreds of mostly bacteriophage genomes, we show that there is a widely distributed natural gap in whole-genome average nucleotide identity values in most, but not all, of these species that can be used to define intra-species units. Therefore, these results advance the molecular toolbox for tracking viral intra-species units and should facilitate future epidemiological and environmental studies.
Identification of HRH1 as an alternative receptor for SARS-CoV-2: insights from viral inhibition by repurposable antihistamines
Authors: Zhong Gang , Li Jinrong , Wang Huiqing 
Published: July 2024

ABSTRACT

Numerous coreceptors have been shown to facilitate hACE2-dependent or hACE2-independent infection by SARS-CoV-2. A recent study published in
mBio
by Yu et al. showed that the histamine receptor H1 (HRH1) functions as an alternative receptor for SARS-CoV-2 via direct binding to viral spike proteins (F. Yu, X. Liu, H. Ou, X. Li, et al., mBio e01088-24, 2024,
https://doi.org/10.1128/mbio.01088-24
). Furthermore, they present compelling evidence that antihistamine drugs targeting HRH1 potently inhibit SARS-CoV-2 entry. This study highlights the therapeutic potential of repurposable antihistamines against COVID-19.
Complete genome sequence of
Escherichia coli
O157:H7 phage Φ241
Authors: Lu Zhongjing , Tseng Tsai-Tien 
Published: July 2024

ABSTRACT

We report the genome sequence of phage Φ241 infecting
Escherichia coli
O157:H7. Phage Φ241 was isolated from an industrial cucumber fermentation at high acidity (pH 3.7) and high salinity (5% NaCl). The phage genome consists of a 157,291 bp circular double-stranded DNA with 203 coding regions and 44.96% GC content.
Immune-related colitis presenting with constipation
Authors: Malkopoulos Athanasios , Mason Robert , Pillai Sooraj , Dzienis Marcin 
Published: July 2024

Anticancer immunotherapies modulate the body’s immune system to recognise and eradicate cancerous cells. However, stimulation of the body’s immune system can also lead to a number of adverse effects when those immune cells target non-cancerous cells in the form of autoimmunity. One relatively common example of this off-target action is colitis.We present three patients who presented atypically with colitis, consequently, leading to a delayed diagnosis. These cases highlight the diverse ways a relatively common immune-related adverse event can present.
Steroid-induced psychosis: a spectrum of neuropsychiatric glucocorticoid side effects
Authors: Brito-Santana Leonor , Medinas Raquel Luís , Neves António , Gago Joaquim 
Published: July 2024

Glucocorticoid-induced neuropsychiatric side effects have been known since their initial usage and frequently manifest in clinical settings. Despite this, they remain unpredictable, variable and complex to manage, impacting patient outcomes and the healthcare system.We report a case of glucocorticoid-induced psychosis after the administration of dexamethasone post-neurosurgical intervention and its evolution with the initiation of chemotherapy. Although initially manic symptoms were prominent, with the beginning of chemotherapy psychotic symptoms dominated the clinical presentation, followed by depressive symptoms. Despite challenges in diagnosis and management, including adverse reactions to antipsychotic treatment, this case provides critical insights into the variable and dynamic nature of neuropsychiatric side effects induced by glucocorticoids.
Evaluation of the Friendship Bench’ Circle Kubatana Tose (CKT): an add-on support group intervention – a mixed-methods pilot interventional cohort study protocol
Authors: Dambi Jermaine , Shava Beatrice K , Tunduwani Tariro Dee , Chitiyo Charmaine , Takaona Tapiwa , Mashunye Thandiwe , Dzapasi Lloyd , Chibanda Dixon 
Published: July 2024

IntroductionMental disorders are endemic. However, the mental health treatment gap remains high, especially in low-resource settings. Task-shifting is a universally recommended strategy to mitigate the care gap. The Friendship Bench (FB), a task-shifting, low-intensity psychotherapy programme founded in Zimbabwe, is effective in managing anxiety and depression. The FB programme offers clients the choice of joining add-on mental health support groups known as Circle Kubatana Tose (CKT). These groups offer an opportunity for continued psychoeducation, social support and economic strengthening. However, the evidence base for the effectiveness of add-on support groups is sparse. We hypothesise that participation in CKT is associated with increased adherence to treatment regimens, social support and well-being. This mixed-methods prospective cohort study seeks to evaluate the intermediate effects (6-month follow-up) of CKT groups, including process outcome evaluation.Methods and analysisWe will recruit participants (N=178) receiving mental healthcare from the FB in Harare primary care clinics. Follow-up assessments will occur at enrolment, 6 weeks, 3 months and 6 months, assessing changes in common mental disorders (depression and anxiety), social support, positive psychological indices (hope and resilience), health-related quality of life, working alliance, economic outcomes (net income) and implementation outcome (feasibility, acceptability/satisfaction and uptake of services). Quantitative data will be analysed using descriptive analysis, bivariate statistics, Cox proportional hazard models and generalised mixed models (maximum likelihood estimation). Qualitative data will be analysed using thematic analysis.Dissemination and ethicsEthical approval was granted by the Medical Research Council of Zimbabwe (MRCZ/A/2427). The findings will inform the potential utility of add-on support groups in the management of anxiety and depression using task-shifting. Dissemination study outcomes will be disseminated in academic journals, social media, conferences and policy briefs.
Mapping regional implementation of ‘Making Every Contact Count’: mixed-methods evaluation of implementation stage, strategies, barriers and facilitators of implementation
Authors: Rodrigues Angela M , Nichol Bethany , Wilson Rob , Charlton Caroline , Gibson Beckie , Finch Tracy , Haighton Catherine , Maniatopoulos Gregory , Giles Emma , Harrison Deborah , Orange Denise , Robson Craig , Harland Jill 
Published: July 2024

BackgroundThe Making Every Contact Count (MECC) programme provides training and materials to support public-facing workers to encourage health-promoting behaviour change by using the day-to-day interactions between organisations and individuals. This project aimed to analyse MECC implementation through a comparative analysis of implementation stage, strategies used for implementation and enablers/barriers of the implementation process within a region in England—the North East and North Cumbria (NENC).MethodsA mixed-methods process evaluation was conducted applying normalisation process theory and theoretical domains framework. MECC programme documents were reviewed and mapped against specific criteria (eg, implementation strategies). An online mapping survey was conducted to establish current implementation/delivery of MECC within NENC settings (eg, local government, healthcare and voluntary community sector). Qualitative research, using individual interviews and group discussions, was conducted to establish further understanding of MECC implementation.ResultsOur findings were informed by reviewing documents (n=5), surveying participants (n=34), interviews (n=18) and group discussions (n=48). Overall, the implementation of MECC within the region was at an early stage, with training mostly delivered between, rather than within, organisations. Qualitative findings highlighted factors that influence stakeholders to implement MECC (eg, organisational goals that were facilitated by MECC implementation, including the prevention agenda), supported resources that facilitate the implementation of MECC (eg, logic models) and enabling factors that promote MECC sustainability across the region (eg, buy-in from leadership and management).ConclusionsThe NENC MECC programme is built around regional leadership that supports the implementation process. This process evaluation identified key influences of MECC implementation across the region. We discuss evidence-based recommendation for policy and practice that can be taken forward to develop targeted strategies to support future MECC implementation. For example, a co-ordinated infrastructure and strategy is needed to combat delivery and implementation issues identified.
Cross-sectional study of cognitive impairment and visual impairment among the elderly population in residential care in India: the Hyderabad Ocular Morbidity in Elderly Study (HOMES)
Authors: Marmamula Srinivas , Kumbham Thirupathi Reddy , Ehrlich Joshua R , Alladi Suvarna , Bloom David E , Friedman David S 
Published: July 2024

ObjectiveTo report the relationship between visual impairment (VI) and cognitive impairment (CI) among the older population living in residential care homes in Hyderabad, India.Study designCross-sectional study.Setting41 homes for the aged centres in the Hyderabad region.Participants965 participants aged ≥60 years from homes for the aged centres.Primary outcome measuresVisual impairment and cognitive impairment.MethodsThe Hindi mini-Mental Status Examination (HMSE) questionnaire was used to assess the cognitive function. The final HMSE score was calculated after excluding vision-dependent tasks (HMSE-VI). A detailed eye examination was conducted, including visual acuity (VA) measurement for distance and near vision, using a standard logarithm of the minimum angle of resolution chart under good illumination. CI was defined as having a HMSE-VI score of ≤17. VI was defined as presenting VA worse than 6/12 in the better-seeing eye. Near VI (NVI) was defined as binocular presenting near vision worse than N8 and distance VA of 6/18 or better in the better-seeing eye. Multiple logistic regression was done to assess the association between VI and CI.ResultsThe mean age (±SD) was 74.3 (±8.3) years (range: 60–97 years). There were 612 (63.4%) women, and 593 (61.5%) had a school education. In total, 260 (26.9%; 95% confidence intervals: 24.2 to 29.9) participants had CI. The prevalence of CI among those with VI was 40.5% compared with 14.6% among those without VI (p<0.01). The logistic regression analysis showed that the participants with VI for distance vision had three times higher odds of having CI (OR 3.09; 95% confidence intervals: 2.13 to 4.47; p<0.01). Similarly, participants with NVI had two times higher odds of having CI (OR 2.11; 95% confidence intervals: 1.36 to 3.29; p<0.01) after adjusting for other covariates.ConclusionsCI was highly prevalent among those with distance and near VI. VI was independently and positively associated with CI after adjusting for potential confounders. Interventions can be planned to address VI in this vulnerable population which could have a ripple effect in preventing cognitive decline.
Effects of a web application based on multimedia animations to support therapeutic exercise for rotator cuff-related shoulder pain: protocol for an open-label randomised controlled trial
Authors: Pérez-Porta Irene , Flórez-García Mariano Tomás , García-Pérez Fernando , Fernández-Matías Rubén , Pérez-Manzanero M Ángeles , Araujo-Narváez Aurora María , Urraca-Gesto M Alicia , Fernández-Lagarejos César , Plaza-Manzano Gustavo , Pérez-Fernández Elia , Velasco-Arribas María 
Published: July 2024

IntroductionRotator cuff-related shoulder pain (RCRSP) is the most common cause of shoulder pain. Currently, exercise is proposed as the first-line treatment for patients suffering from RCRSP. However, adherence to therapeutic exercise programmes can be poor in the long term in a home setting. The aim of this study is to evaluate the effects of adding video animations to a traditional paper-based exercise programme.Methods and analysisA single-centre, randomised, open-labelled clinical trial will be conducted in a hospital in Spain. Adults aged between 18 and 80 years diagnosed with RCRSP who meet the eligibility criteria will be included. Patients (n=132) will be randomised into two groups, with both receiving paper-based exercises, and the experimental group will also be provided with video animations. The participants will receive seven face-to-face physical therapy sessions and will be asked to perform the exercises at home for 6 months. The primary outcome measure will be the Shoulder Pain and Disability Index, measured at baseline, 3 weeks, 3 months (primary analysis) and 6 months. Secondary outcomes will be the patient’s pain intensity during the last week (rest, during movement and at night); expectations of improvement; satisfaction with treatment; impression of improvement; perceived usability, usefulness and satisfaction of multimedia animations; and adherence to exercises. Generalised least squares regression models with an autoregressive-moving average lag one correlation structure will be implemented, with an intention-to-treat analysis.Ethics and disseminationThis study has been approved by the ethics committee of Hospital Universitario Fundación Alcorcón (Madrid, Spain), reference number CI18/16. All participants will sign an informed consent. The results will be published in a peer-reviewed scientific journal.Trial registrationClinicalTrials.gov,NCT05770908.