bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESAFIOS E CONSQUISTAS: Experiências da Enfermagem do Trabalho em um Hospital
Authors: Kenupp Suellen de Souza , Loureiro Lucrécia Helena , Santos Douglas Markonne de Souza , Balbino Carlos Marcelo 
Published: July 2024

Trata-se de um relato de experiência de uma enfermeira do trabalho sobre o cotidiano vivenciado durante práticas assistências e gerenciais de cuidado em saúde ocupacional, ao longo dos anos em um hospital privado que atende pacientes do Sistema Único de Saúde (SUS) situado na região Sul Fluminense do Rio de Janeiro. Tem como objetivo principal relatar as práticas cuidativas realizadas pela profissional no nosocômio, que estão relacionadas a atividades de rotinas burocráticas e de cuidado; educação permanente com profissionais da enfermagem, da saúde e da administração a fim de contribuir com a ampliação de conhecimentos e mudanças de atitudes salutares às boas práticas estabelecidas pela legislação em segurança e saúde ocupacional brasileira. Menciona-se que há oportunidades para atuar em campanhas de vacinação, promoção da saúde e prevenção de doenças ocupacionais e profissionais, treinamentos e palestras educativas. Observa-se que a equipe de enfermagem exerce períodos ininterruptos de atividades, que apresentam sobrecarga de trabalho; ocasionando o adoecimento e as ausências evitáveis dos profissionais. Fato relatado em conversas informais sobre o cansaço físico e mental durante as longas horas de jornada trabalhadas, o cansaço excessivo, o ganho de peso, a falta de paciência, o esgotamento físico e mental, a falta de tempos com a família, preocupações com os filhos e da necessidade de preservar outros vínculos de trabalho para manter as finanças familiares. Conclui-se que a atuação da enfermagem do trabalho no ambiente hospitalar contribui para saúde integral dos profissionais atendidos pelo setor de medicina ocupacional, de maneira a prevenir e acompanhar ambulatoriamente os funcionários. Assim, colabora para a diminuição das ocorrências de absentismo ao promover a gestão em enfermagem, organizando e planejando as escalas dos trabalhadores necessárias para a completude dos afazeres assistenciais e gerenciais do hospital.
Improvement of the Cognitive Abilities in a Chronic Generalized Anxiety Disorder and Moderate Depression Case using a Novel Integrated Approach: The Cognitome Program
Authors: Mohita Shrivastava 
Published: July 2024

Cognitive impairment has been increasingly observed among patients with anxiety disorders and major depressive disorders impacting their normal daily functioning as well as quality of life. A multitude of evidence suggests that the most affected cognitive abilities are memory, attention, perception, and executive functioning in patients with anxiety and depression. Impairment in these higher-order cognitive functions can be attributed to age, education, diet, hormonal changes, stress, and prolonged use of drugs/alcohol/ medicines. To address the issues related to cognitive impairment various non-pharmacological therapeutic modalities such as Cognitive remediation approaches viz; cognitive rehabilitation, cognitive stimulation, and cognitive training; Audio-visual entrainment; mindfulness-based interventions; and neurofeedback have come into play in recent years. It is imperative to understand that the ability to test, measure, and monitor cognitive performance along with implementing cognitive remediation approaches viz; cognitive stimulation, cognitive training, etc. across the lifespan helps in early identification, accessing treatments faster, staying healthy for longer, and improving overall quality of life. This article discusses a case study of a client suffering from generalized anxiety disorder and moderate depression who after undergoing and following a novel therapeutic approach, ‘The Cognitome Program’ has shown credible improvement in cognitive abilities, along with a prominent reduction in the symptoms of anxiety, depression, and better psychological and physical well-being. Guided by the concept of neuroplasticity and cognitive plasticity, our innovative neuroscientific holistic program- ‘The Cognitome Program’ empowers unlocking hidden cognitive potential using cutting-edge methodologies and personalized strategies.
Analisis Mengenai Studi Kelayakan Usaha Ecoblock Dalam Rangka Daur Ulang Sampah Plastik Di Salatiga
Authors: Karunianto Mu'amar Andi , Tejanagara Orlando Samuel , Napitupulu Obi Sepanya , Martono Samuel 
Published: July 2024

Sampah telah menjadi permasalahan utama dunia terlebih jika dikaitkan dengan keberlangsungan hidup manusia. Sampah yang tidak dikelola dengan baik akan membuat pencemaran di lingkungan sekitar, untuk mencegah hal tersebut pemerintah menerapkan program 3R (Reduce, Reuse, dan Recycle). Adanya permasalahan tersebut membuat sebuah peluang bisnis yang dapat membuat sampah plastik menjadi sebuah produk dengan nilai jual. Studi kelayakan usaha ini berfokus dalam menganalisis sebuah proyek yang nantinya dapat dilakukan oleh mitra seperti Pemerintah Daerah ataupun investor seperti sebuah perusahaan. Proyek ecoblock merupakan salah satu upaya masyarakat melalui program Reuse dan Recycle dalam mengurangi sampah terutama sampah plastik yang diubah menjadi barang dengan nilai guna sehingga mampu bermanfaat secara ekonomi dan sosial yang akan dilakukan di daerah TPA Ngronggo Salatiga. Periode dilakukannya penelitian dari 29 Agustus 2023 hingga 11 Desember 2023 yang merupakan jenis penelitian (field research) dengan metode kualitatif. Teknik analisis dalam studi kelayakan usaha proyek ecoblock berdasarkan beberapa aspek yaitu aspek pasar, aspek teknis, aspek manajemen, aspek hukum, dan aspek finansial. Melalui penilaian yang telah dilakukan dapat disimpulkan dari kelima aspek analisis bahwa proyek ecoblock dapat dikatakan layak sehingga investor ataupun mitra yang ingin melaksanakan proyek ecoblock dapat dilaksanakan.
Non-clinical Studies of Radiopharmaceuticals: Analysis of National and International Regulatory Practice (Review)
Authors: Klementyeva O. E. , Smirnova A. V. , Kulbachevskaya N. Yu. , Grigorieva E. Yu. , Lagodzinskaya Yu. S. , Gevorkyan T. G. 
Published: July 2024

INTRODUCTION. Currently in the Russian Federation and the Eurasian Economic Union (EAEU), the conduct of non-clinical studies of radiopharmaceuticals is regulated by general guidelines on non-clinical studies, which are applicable to multiple groups of medicinal products but do not accommodate the characteristics of radiopharmaceuticals.AIM. The study aimed to substantiate the need for methodological guidelines regulating non-clinical studies of radiopharmaceuticals, taking into account global regulatory practice.DISCUSSION. The authors analysed the Russian and EAEU guidelines regulating non-clinical studies in general as well as international publications on non-clinical studies of radiopharmaceuticals, including guidelines by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the International Atomic Energy Agency (IAEA). The analysis revealed the need for terminology harmonisation. This article describes the aspects specific to radiopharmaceuticals that limit the applicability of general guidelines to non-clinical studies of radiopharmaceuticals. Subchronic toxicity studies based on inactive formulations do not account for the contribution of radionuclide emission to the biological effects of therapeutic radiopharmaceuticals. The authors suggest that systemic toxicity studies of finished dosage forms should use single-dose chronic toxicity protocols.CONCLUSIONS. It is necessary to develop and implement up-to-date methodological guidelines for conducting non-clinical studies of radiopharmaceuticals to reduce potential risks in the application of these medicinal products. This requires factoring in different requirements for diagnostic and therapeutic radiopharmaceuticals, with due consideration of radiation safety requirements. When drafting guidelines for non-clinical studies of radiopharmaceuticals, regulators should keep in mind the applicable guidelines by the FDA, EMA, and IAEA. A list of mandatory studies should be compiled, and uninformative studies should be excluded from the requirements for radiopharmaceuticals.
Genetic Polymorphisms of Carnosine Synthase -1(ATPGD1) and Serum Carnosine Levels in Relation to Cardiovascular Diseases in Iraqi Type 2 Diabetics
Authors: Haneen Subhee Shaheed  , Shatha H Ali  
Published: July 2024

Diabetes mellitus (DM) is a metabolic disorder specified by persistent hyperglycemia that occurs when β-cell insulin production became unable to control blood glucose with deterioration of response for insulin. The consequent development of DM complications with increased risk for many diseases caused by damaged variety of biological systems, including blood vessels, eyes, kidneys, heart, and nerves. Carnosine is a natural dipeptide (β-alanyl-L-histidine) expressed in both the central nervous system and periphery, it occurs in several tissues most notably in muscle where they represent an appreciable fraction of the total water-soluble nitrogen-containing compounds. Carnosine is synthesized by a cytosolic amino acid ligase, carnosine synthase-1 (CARNS1; also known as ATP-grasp domain–containing protein 1, ATPGD1; EC 6.3.2.11).Several biological and physiological functions have been attributed to carnosine, such as being an anti-inflammatory and antioxidant agent, antiglycating actions, and as a modulator of mitochondrial metabolism. Carnosine level in human serum is affected by several enzymes like carnosine synthase-1 (responsible of carnosine synthesis),thus any genetic polymorphisms in these enzymes could have an impact on enzymes levels and therefore serum carnosine level with consequent increased risk for many diseases.
This study was aimed to estimate the occurrence of Carnosine synthase -1 SNP (rs 1790733) on chromosom11 (intron –variant) in Iraqi type 2 diabetics with and without cardio vascular diseases and it’s correlation with serum levels of carnosine & carnosine synthase-1 and their association with CVD as T2DM complication.

To achieve this aim Enzyme Linked Immunosorbent Assay (ELISA) specific kits were used to estimate serum levels of carnosine & carnosine synthase-1. High resolution melt technique (HRM) was applied for detecting gene polymorphism of carnosine synthase-1 gene (ATPGD1).
The results showed that gene polymorphism of SNP (rs1790733) increased the chance of CVD in T2DM patients by 84.5% by its effect to decrease the mean of serum levels of carnosine by decreased carnosine synthase-1 level that may correlate to development of CVD in T2DM patients.
The specifics of the information security culture of technical university students
Authors: Solovyova Svetlana Anatolevna , Kulebyaev Mikhail Anatolevich 
Published: July 2024

The article presents the results of a study of the peculiarities of the information security culture of students of technical universities. The relevance is due to the globalization of digital technologies penetrating into all spheres of human life, both socio-political, state, professional and personal, which clearly determines the need for the formation and development of an information security culture. This issue is especially relevant in relation to students of technical universities – future specialists in the engineering industry, since they will work with technical systems and information that may be subject to various threats in the field of information security.
The effectiveness of programs for the formation and development of an information security culture is largely determined by the study of the features and specifics of the manifestation of its components (technical, cognitive, behavioral, and value-semantic). The study was carried out in the form of a ascertaining experiment using the author's diagnostic questionnaire &quot;The level of information security culture&quot;. 781 students of the Volga branch of MADI took part in the study. Based on the highlighted structure of the information security culture, the study established the specific features of the formation of its components among students of a technical university, namely, the results of the study revealed insufficient fixation in the minds of students of a technical university of the values of information security culture, a low level of patterns of safe behavior, with the general development of technical literacy in the digital space.
ASSOCIAÇÃO DA ATIVIDADE FÍSICA DE MODERADA A VIGOROSA COM A CIRCUNFERÊNCIA DE BRAÇO EM CRIANÇAS
Authors: Rosa Vieira Pasqualinoto Sérgio , Luis de Moraes Ferrari Gerson , Rossato de Victo Eduardo , Keihan Rodrigues Matsudo Victor 
Published: July 2024

Objetivo: Verificar a associação da atividade física de moderada a vigorosa (AFMV), avaliada de forma objetiva, com a circunferência de braço (CB) em crianças. Métodos: Foi realizado um estudo transversal, com amostra de 89 crianças de ambos os sexos, idades entre 9 e 11 anos, da cidade de Ilhabela. As variáveis antropométricas analisadas foram: estatura (cm), peso corporal (kg), índice de massa corporal (IMC; kg/m2), adiposidade corporal (mm), circunferência da cintura (CC) e CB (cm). As crianças foram classificadas como obesas com CB >25,3 cm. Nos meninos, o ponto de corte da CB para obesidade foi >24,1 cm, nas meninas 25,6 cm. A AFMV e o tempo sedentário (TS) total foram avaliados de forma objetiva por acelerômetros que foram utilizados durante sete dias consecutivos. Resultados: As meninas apresentaram valores significantemente superiores quando comparadas aos meninos na estatura, peso corporal, adiposidade corporal e TS. Em média, os meninos acumularam mais tempo em AFMV (62,5 min/dia) do que as meninas (43,1 min/dia). No total da amostra, a CB associou-se fortemente com peso corporal, adiposidade corporal, IMC e CC (r≥0,83; p<0,0001). Associações negativas e significantes entre AFMV e CB foram encontradas na amostra total (r: -0,36), nos meninos (r: -0,40) e nas meninas (r: -0,28). Foram encontradas associações significantes da AFMV com a CB independente do TS no total da amostra (OR: 0,950; IC95%: 0,911-0,990) e nos meninos (OR: 0,884; IC95%: 0,793-0,985). Nas meninas, não houve associação significante da AFMV com a CB. Conclusão: Foram encontradas associações entre AFMV e CB, independentemente do TS, para o total da amostra e para os meninos. Nas meninas não houve associação da AFMV com a CB.
META ANALISIS KEMAMPUAN PEMAHAMAN MATEMATIS SISWA MELALUI PEMODELAN MATEMATIKA PADA PEGAS
Authors: Octiviani Pulungan Nurbaiti , Waldi Barus Leo , Erika Dewi Siska , Lutfitasari Devi , Desniarti Desniarti 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui kemampuan pemecahan masalah matematis siswa dalam menyelesaikan soal melalui meta-analisis di beberapa sekolah. Metodologi penelitian ini menggunakan meta-analisis. Data kemampuan menyelesaikan soal diambil dari data 11 penelitian terdahulu berupa 5 jurnal review, dan 6 skripsi yang berbeda-beda. Prosedur meta-analisis yang digunakan dalam penelitian ini adalah sebagai berikut: 1) mengidentifikasi judul yang untuk dirangkum, 2) memilih jenis publikasi yang akan dikumpulkan, 3) mengumpulkan hasil penelitian, 4) mencatat data penelitian, 5) menghitung tingkat dampak dari setiap hasil penelitian. Hasil penelitian menunjukkan bahwa kemampuan pemecahan matematikasiswa SMP cenderung lebih berkembang dalam penyelesaian matematika siswa SMA. Kemampuan pemecahan matematika siswa menurut tahun belajar cenderung tidak stabil dari tahun ke tahun, sedangkan kemampuan pemecahan matematika siswa berdasarkan model/metode pembelajaran belum maksimal.
Analisis Nilai Termal Selubung Bangunan (OTTV) Pada Bangunan Gedung Direktorat Politeknik Negeri Pontianak sebagai Indikator Penilaian Kinerja Bangunan Gedung Hijau menggunakan Building Compliance Form V3.0
Authors: Wibowo Taufik , Yudiarma Yudiarma , Fitriyanto Ari 
Published: July 2024

Kebijakan pemerintah dalam mengurangi emisi karbon diantaranya adalah dengan mengeluarkan Peraturan Menteri PUPR Nomor 21 tahun 2021 tentang Penilaian Kinerja Bangunan Gedung Hijau. Salah satu kriteria penilaian dalam Bangunan Gedung Hijau berdasarkan Petunjuk Teknis Penilaian Bangunan Gedung Hijau adalah OTTV dan WWR. Kedua kriteria ini menjadi poin yang penting dalam kategori penilaian Efisiensi Penggunaan Energi pada bagian Selubung Bangunan. OTTV yang disyaratkan pada Bangunan Gedung Hijau tidak boleh lebih dari 35 Watt/m2. Sedangkan untuk WWR kurang dari 30%. Politeknik Negeri Pontianak sebagai institusi Pendidikan milik pemerintah juga memiliki bangunan gedung yang diharapkan dapat memenuhi standar Bangunan Gedung Hijau. Oleh karena itu perlu dilakukan penyelidikan awal dalam bentuk penelitian terhadap kriteria OTTV dan WWR pada bangunan-bangunan gedung utama di kampus Politeknik Negeri Pontianak. Sebagai obyek penelitian dipilih bangunan Gedung Direktorat Politeknik Negeri Pontianak. Tahapan dan metode penelitian dilakukan yaitu dengan mengumpulkan data berupa gambar bangunan dan kondisi termal ruangan. Dilanjutkan dengan proses analisis dengan spreadsheet Building Compliance Form v3.0 dan hasilnya akan dilakukan pembahasan. Dari penelitian ini diperoleh hasil kondisi existing Gedung Direktorat Politeknik Negeri Pontianak mempunyai nilai OTTV sebesar 37,65 Watt/m2 dan WWR sebesar 34,28%, dimana keduanya masih belum memenuhi standar 35 Watt/m2 untuk OTTV dan 30% untuk WWR. Walaupun demikian, dengan pengubahsuaian yang dilakukan dengan penambahan shading horizontal dan pengurangan luasan bidang kaca pada bagian tower, maka bisa didapatkan nilai OTTV sebesar 31,22 W/m2 dan nilai WWR sebesar 29,12%. Sehingga nilai tersebut bisa memenuhi standar dan mendapatkan poin penuh untuk kategori efisiensi energi. Dampak lainnya adalah Gedung Direktorat Politeknik Negeri Pontianak sebagai Bangunan Gedung Negara setelah dilakukan tindakan pengubahsuaian dapat diusulkan untuk mengambil sertifikat Bangunan Gedung Hijau.
Hubungan Pengetahuan Orang Tua dengan Karies Molar Satu Permanen pada Anak Usia 9-12 Tahun
Authors: Amalia Yuanita , Amperawati Metty , Isnawati  , Nurwati Bunga 
Published: July 2024

Prevalensi karies gigi pada usia 6 tahun yang telah mengalami karies pada gigi molar permanen sebanyak 20%, dan meningkat 60% pada usia 8 tahun, 85% pada 10 tahun dan 90% pada usia 12 tahun dimana usia tersebut merupakan usia anak sekolah. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan orang tua tentang pertumbuhan gigi dengan karies gigi molar satu permanen pada anak usia 9-12 tahun di MIS Raudhatul Jannah Martapura. Penelitian ini merupakan penelitian survei analitik. Jumlah sampel 33 responden dengan teknik total sampling. Analisis data menggunakan uji Chi Square. Hasil penelitian didapatkan pengetahuan orang tua tentang pertumbuhan gigi sebagian besar kurang baik (54,5%), karies molar satu permanen sebagian besar tinggi (54,5%). Uji statistik dengan Chi Square didapatkan ρ > α (0,970 > 0,05). Kesimpulan penelitian tidak ada hubungan antara pengetahuan orang tua tentang pertumbuhan gigi dengan karies gigi molar satu permanen pada anak usia 9-12 tahun di MIS Raudhatul Jannah Martapura.
Analisis Raw Material Inventory pada UMKM Charu Dhatri Kota Madiun
Authors: Cahyaningtyas Putri , Isnaini Wildanul , Adi Kusuma Yudha 
Published: July 2024

UMKM Charu Dhatri Kota Madiun merupakan usaha yang bergerak di bidang industri kreatif dengan bahan baku dari karung goni. UMKM Charu Dhatri Kota Madiun ini memiliki perhitungan bahan baku yang belum terstruktur secara rinci dan baik. Penelitian ini diawali dengan meramalkan dengan metode Time series untuk menentukan permintaan. Dengan metode Winter’s Exponential Smoothing dengan hasil pada Grocery Bag (5,21), Tas Custom (6,64), dan Dompet Custom (2,01). Frekuensi pembelian bahan baku pada UMKM Charu Dhatri Kota Madiun dihitung dengan menggunakan metode Economic Order Quantity (EOQ) dengan hasil pada Grocery Bag (25 m) dengan hasil frekuensi pemesanan 5 kali dalam setahun dan nilai Safety Stock (22 m), Tas Custom (46 m) dengan frekuensi pemesanan 9 kali dengan nilai Safety Stock (20m), dan Dompet Custom (14 m) dengan frekuensi pemesanan 3 kali dan Safety Stock senilai (6 m). Menentukan kapan seharusnnya UMKM Charu Dhatri Kota Madiun melakukan pemesanan kembali dengan metode Re Order Point (ROP) dengan hasil pada Grocery bag (24 m), Tas Custom (22 m), dan Dompet Custom (8 m). Sehingga kesimpulan dari penelitian ini dengan adanya perhitungan peramalan, Economic Order Quantity (EOQ), Frequensy, Safety Stock, serta Re Order Point (ROP) sangat membantu UMKM Charu Dhatri untuk memenuhi permintaan produk dari konsumen.
Study of the antmicrobial action and disinfecting properties of the hypochloritic acid solution obtained by the electrolysis method
Authors: Brezvyn O. M. , Kotsiumbas I. Ya. , Hyrenko D. V. , Luk'yanenko T. V. , Shmychkova O. B. , Dmitrikova L. V. , Velichenko O. B. 
Published: July 2024

The article presents the materials for the study of the antimicrobial action against the test strains of microorganisms: E. coli, S. aureus, P. aeruginosa, B. subtilis, C. albicans, as well as the disinfecting properties of hypochlorite acid (HClO), obtained by the electrolysis method. It has been established that hypochlorous acid exhibits pronounced bactericidal, sporicidal, and fungicidal effects, has multifunctional and long-term activity against various bacteria and fungi, and is safe for the environment. The conducted studies established that the effectiveness of the antimicrobial action of hypochlorous acid depended on the type of microorganisms, concentration, and duration of exposure. The minimum bactericidal concentration of hypochlorous acid for E. coli and P. aeruginosa was 100 mg/l; for S. aureus and the yeast-like fungus C. albicans, it was at the level of 150 mg/l. The product under study showed bactericidal activity against E. coli, S. aureus, P. aeruginosa, B. subtilis, and C. albicans at a concentration of 500 mg/l after exposure for 30 minutes. Under the presence of a protein load, the ability of hypochlorous acid to disinfect an object from spore-forming microorganisms B. subtilis at the level of 2.8 lg was confirmed. At the same time, the obtained results indicated the absence of a linear relationship between the amount of organic load and sporicidal activity. To achieve a 100% fungicidal effect against A. niger in the presence of a protein load, the concentration of the tested agent should not be less than 700 mg/l, and the contact time should not be less than 3 hours. The use of HOCl, obtained by electrolysis, as a veterinary remedy is effective, as it has a high safety profile and a favorable therapeutic index and mimics the reaction of the immune system of animals to invasive microorganisms. Namely, it affects the microbial cell's physicochemical processes, disrupts the plasma membrane's permeability, and interferes with its normal functioning, which in turn leads to inhibition of activity or death in general. HOCl is one of the few substances of natural origin that is safe for humans and animals and lethal to almost all known pathogens.