bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart Rate at Hospital Discharge in Patients With Heart Failure Is Associated With Mortality and Rehospitalization
Authors: Laskey Warren K. , Alomari Ihab , Cox Margueritte , Schulte Phillip J. , Zhao Xin , Hernandez Adrian F. , Heidenreich Paul A. , Eapen Zubin J. , Yancy Clyde , Bhatt Deepak L. , Fonarow Gregg C. ,   the AHA Get With The Guidelines‐Heart Failure Program
Published: April 2015

Background

Whether heart rate upon discharge following hospitalization for heart failure is associated with long‐term adverse outcomes and whether this association differs between patients with sinus rhythm (
SR
) and atrial fibrillation (
AF
) have not been well studied.

Methods and Results

We conducted a retrospective cohort study from clinical registry data linked to Medicare claims for 46 217 patients participating in Get With The Guidelines
®
–Heart Failure. Cox proportional‐hazards models were used to estimate the association between discharge heart rate and all‐cause mortality, all‐cause readmission, and the composite outcome of mortality/readmission through 1 year. For
SR
and
AF
patients with heart rate ≥75, the association between heart rate and mortality (expressed as hazard ratio [
HR
] per 10 beats‐per‐minute increment) was significant at 0 to 30 days (
SR
:
HR
1.30, 95%
CI
1.22 to 1.39;
AF
:
HR
1.23, 95%
CI
1.16 to 1.29) and 31 to 365 days (
SR
:
HR
1.15, 95%
CI
1.12 to 1.20;
AF
:
HR
1.05, 95%
CI
1.01 to 1.08). Similar associations between heart rate and all‐cause readmission and the composite outcome were obtained for
SR
and
AF
patients from 0 to 30 days but only in the composite outcome for
SR
patients over the longer term. The
HR
from 0 to 30 days exceeded that from 31 to 365 days for both
SR
and
AF
patients. At heart rates <75, an association was significant for mortality only for both
SR
and
AF
patients.

Conclusions

Among older patients hospitalized with heart failure, higher discharge heart rate was associated with increased risks of death and rehospitalization, with higher risk in the first 30 days and for
SR
compared with
AF
.
Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults
Authors: Berger Assaf , Grossman Ehud , Katz Moshe , Kivity Shaye , Klempfner Robert , Segev Shlomo , Goldenberg Ilan , Sidi Yehezkel , Maor Elad 
Published: April 2015

Background
The aim of the present study was to examine whether exercise blood pressure can be used to predict the development of hypertension in normotensive middle‐aged adults.

Methods and Results

We investigated 7082 normotensive subjects who were annually screened in a tertiary medical center and completed maximal treadmill exercise tests at each visit. After the initial 3 years, subjects were divided into approximate quartiles according to their average exercise systolic and diastolic blood pressure responses (≤158; 158 to 170; 170 to 183; ≥183 mm Hg for systolic blood pressure and ≤73; 73 to 77; 77 to 82; ≥82 mm Hg for diastolic blood pressure). Mean age of the study population was 48±9 years and 73% were men. Average baseline resting blood pressure was 120/77±12/7 mm Hg. During a follow‐up of 5±3 years, 1036 (14.6%) subjects developed hypertension. The cumulative probability of new‐onset hypertension at 5 years was significantly increased with increasing quartiles of exercise systolic blood pressure (5%, 9%, 17%, and 35%, respectively;
P
<0.001), with a similar association shown for diastolic blood pressure. After adjustment for baseline resting blood pressure and clinical parameters, each 5‐mm Hg increments in exercise either systolic or diastolic blood pressures were independently associated with respective 11% (
P
<0.001) and 30% (
P
<0.001) increased risk for the development of hypertension.

Conclusions
In normotensive middle‐aged individuals, blood pressure response to exercise is associated with future development of hypertension.
Acute toxicity and accumulation of microcystin-leucine-arginine in the crayfish Procambarus clarkii (Girard, 1852)
Authors: An Zhenhua , An Zhenhua , Sun Longsheng , An Zhenhua , Sun Longsheng , Wang Ping 
Published: April 2015

The aim of this study was to determine the acute toxicity effect and the accumulation of microcystin-leucine-arginine (MC-LR) on the crayfish Procambarus clarkii (Girard, 1852). Juvenile P. clarkii (5.47 ± 1.3 g) were cultured under 5 different MC-LR concentrations (0.3, 0.6, 1.2, 2.4, 4.8 mg/l), then the acute toxicity effect was observed. The median lethal concentration (LC50) of MC-LR on juvenile P. clarkii was 3.741 mg/l at 24 h, 1.494 mg/l at 48 h, 0.817 mg/l at 72 h and 0.567 mg/l at 96 h. Accumulation of MC-LR was measured in different organs of mature P. clarkii (58.7 ± 3.8 g) exposed to 0.3 mg/l MC-LR for 120 h. The detected MC-LR concentration decreased in the sequence: hepatopancreas > ovary > abdominal muscle > intestine. Hepatopancreas and ovary were found to be the main targets of the toxin. The results suggested that the MC-LR produced by cyanobacteria blooms could not only reduce the survival rate of juvenile P. clarkii but also affect the fecundity of mature crayfish. This research also provides a reference basis for the detection and assessment of the pollution of water bodies in P. clarkii culture.
A review of Billaea Robineau-Desvoidy of the eastern Palearctic and Oriental regions (Diptera: Tachinidae)
Authors: ZHANG CHUN-TIAN , SHIMA HIROSHI , WANG QIANG , TSCHORSNIG HANS-PETER 
Published: April 2015

The species of Billaea Robineau-Desvoidy (Diptera, Tachinidae) from the eastern Palearctic and Oriental regions are revised. Ten described species are recognized, viz. B. atkinsoni (Baranov) (new records for Japan, Laos, Malaysia, Pakistan and Thailand), B. ficorum (Townsend), B. fortis (Rondani), B. impigra Kolomiets (new record for China), B. kolomyetzi Mesnil, B. malayana Malloch, B. morosa Mesnil, B. robusta Malloch, B. steini (Brauer et Bergenstamm) and B. triangulifera (Zetterstedt) and nine species are described as new to science, B. brevicauda Zhang et Shima sp. nov. (China), B. carinata Zhang et Shima sp. nov. (China), B. chinensis Zhang et Shima sp. nov. (China and Vietnam), B. flava Zhang et Wang sp. nov. (China), B. kurahashii Zhang et Shima sp. nov. (Laos and Thailand), B. micronychia Zhang et Shima sp. nov. (China and Japan; previously misidentified from China as B. irrorata (Meigen)), B. papei Zhang et Shima sp. nov. (Malaysia), B. setigera Zhang et Shima sp. nov. (China) and B. verticalis Shima et Zhang sp. nov. (China). Billaea fasciata (Townsend, 1928) is treated as a junior synonym of B. ficorum (Townsend, 1916), syn. nov. Billaea irrorata is no longer recorded from the eastern Palearctic. A key to 19 species of Billaea from the eastern Palearctic and Oriental regions and 101 figures of male terminalia, bodies, heads and abdomens are given.
An Interpretation of Cloud Overlap Statistics
Authors: Tompkins Adrian M. , Di Giuseppe Francesca 
Published: April 2015

Abstract
Observational studies have shown that the vertical overlap of cloudy layers separated by clear sky can exceed that of the random overlap assumption, suggesting a tendency toward minimum overlap. In addition, the rate of decorrelation of vertically continuous clouds with increasing layer separation is sensitive to the horizontal scale of the cloud scenes used. The authors give a heuristic argument that these phenomena result from data truncation, where overcast or single cloud layers are removed from the analysis. This occurs more frequently as the cloud sampling scale falls progressively below the typical cloud system scale. The postulate is supported by sampling artificial cyclic and subsequently more realistic fractal cloud scenes at various length scales. The fractal clouds indicate that the degree of minimal overlap diagnosed in previous studies for discontinuous clouds could result from sampling randomly overlapped clouds at spatial scales that are 30%–80% of the cloud system scale. Removing scenes with cloud cover exceeding 50% from the analysis reduces the impact of data truncation, with discontinuous clouds not minimally overlapped and the decorrelation of continuous clouds less sensitive to the sampling scale. Using CloudSat–CALIPSO data, a decorrelation length scale of approximately 4.0 km is found. In light of these results, the previously documented dependence of overlap decorrelation length scale on latitude is not entirely a physical phenomenon but can be reinterpreted as resulting from sampling cloud systems that increase significantly in size from the tropics to midlatitudes using a fixed sampling scale.
Parametric Sensitivity Analysis for the Asian Summer Monsoon Precipitation Simulation in the Beijing Climate Center AGCM, Version 2.1
Authors: Yang Ben , Zhang Yaocun , Qian Yun , Wu Tongwen , Huang Anning , Fang Yongjie 
Published: April 2015

Abstract
In this study, the authors apply an efficient sampling approach and conduct a large number of simulations to explore the sensitivity of the simulated Asian summer monsoon (ASM) precipitation, including the climatological state and interannual variability, to eight parameters related to the cloud and precipitation processes in the Beijing Climate Center AGCM, version 2.1 (BCC_AGCM2.1). The results herein show that BCC_AGCM2.1 has large biases in simulating the ASM precipitation. The precipitation efficiency and evaporation coefficient for deep convection are the most sensitive parameters in simulating the ASM precipitation. With optimal parameter values, the simulated precipitation climatology could be remarkably improved, including increased precipitation over the equatorial Indian Ocean, suppressed precipitation over the Philippine Sea, and more realistic mei-yu distribution over eastern China. The ASM precipitation interannual variability is further analyzed, with a focus on the ENSO impacts. It is shown that simulations with better ASM precipitation climatology can also produce more realistic precipitation anomalies during El Niño–decaying summer. In the low-skill experiments for precipitation climatology, the ENSO-induced precipitation anomalies are most significant over continents (vs over ocean in observations) in the South Asian monsoon region. More realistic results are derived from the higher-skill experiments with stronger anomalies over the Indian Ocean and weaker anomalies over India and the western Pacific Ocean, favoring more evident easterly anomalies forced by the tropical Indian Ocean warming and stronger Indian Ocean–western Pacific teleconnection as observed. The model results reveal a strong connection between the simulated ASM precipitation climatological state and interannual variability in BCC_AGCM2.1 when key parameters are perturbed.
Global Maps of Streamflow Characteristics Based on Observations from Several Thousand Catchments*
Authors: Beck Hylke E. , de Roo Ad , van Dijk Albert I. J. M. 
Published: April 2015

AbstractStreamflow Q estimation in ungauged catchments is one of the greatest challenges facing hydrologists. Observed Q from 3000 to 4000 small-to-medium-sized catchments (10–10 000 km2) around the globe were used to train neural network ensembles to estimate Q characteristics based on climate and physiographic characteristics of the catchments. In total, 17 Q characteristics were selected, including mean annual Q, baseflow index, and a number of flow percentiles. Testing coefficients of determination for the estimation of the Q characteristics ranged from 0.55 for the baseflow recession constant to 0.93 for the Q timing. Overall, climate indices dominated among the predictors. Predictors related to soils and geology were relatively unimportant, perhaps because of their data quality. The trained neural network ensembles were subsequently applied spatially over the entire ice-free land surface, resulting in global maps of the Q characteristics (at 0.125° resolution). These maps possess several unique features: they represent observation-driven estimates, they are based on an unprecedentedly large set of catchments, and they have associated uncertainty estimates. The maps can be used for various hydrological applications, including the diagnosis of macroscale hydrological models. To demonstrate this, the produced maps were compared to equivalent maps derived from the simulated daily Q of four macroscale hydrological models, highlighting various opportunities for improvement in model Q behavior. The produced dataset is available online (http://water.jrc.ec.europa.eu/GSCD).
Successful Treatment of Macroglossia Due to Lymphatic Malformation With Sirolimus
Authors: Yesil Sule , Bozkurt Ceyhun , Tanyildiz Hikmet Gülsah , Tekgunduz Sibel Akpinar , Candir Mehmet Onur , Toprak Sule , Sahin Gurses 
Published: April 2015

Objective: To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation. Methods: Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg/m2 per dose, administered orally, twice daily at approximately 12-hour intervals. Results: After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved. Conclusion: This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases.
Outcomes of an Alternating Ibuprofen and Acetaminophen Regimen for Pain Relief After Tonsillectomy in Children
Authors: Liu Christopher , Ulualp Seckin O. 
Published: April 2015

Objectives: To determine the outcomes of alternating doses of ibuprofen and acetaminophen in the treatment of post-tonsillectomy pain in children and to identify characteristics of children who had inadequate pain control. Methods: The medical records of children who received alternating doses of ibuprofen and acetaminophen for post-tonsillectomy pain between August 2012 and November 2013 at a tertiary care children’s hospital were reviewed. Incidences of postoperative bleeding and unresolved pain were determined. Results: A total of 583 patients (304 males, 279 females, age range =1-18 years) had received alternating doses of ibuprofen and acetaminophen after tonsillectomy and adenoidectomy. Of the 583 patients, 56 (9.6%) reported inadequate pain control. Age, sex, obesity, presence of comorbid conditions, indications for surgery, and concurrent surgical procedures were not different between children who had adequate analgesia and children who had unresolved pain. Twenty-four patients (4.1%) had postoperative bleeding. Nine patients (1.5%) required surgical intervention for bleeding. Conclusions: Alternating doses of ibuprofen and acetaminophen provided an effective treatment for post-tonsillectomy pain in the majority of children and did not increase rate of bleeding. Means of improving response rate to alternating doses of ibuprofen and acetaminophen merit further investigation.
Kurdola: Product Portfolio Decision
Authors: Mukherjee Jaydeep 
Published: April 2015

MOMCO was a leading manufacturer and marketer of branded edible oils in India. In its product portfolio, Kurdola was PUFA (poly unsaturated fatty acid) based premium edible oil. It was established in the market as the best product for keeping the heart healthy, based on the findings of medical research. MOMCO’s had in its product portfolio “Healthy tasty blend”, a balanced blend of PUFA and MUFA (mono unsaturated fatty acid), which was positioned as economical product with considerably lower margins for MOMCO. New medical research now established that a blend of PUFA and MUFA was better for heart than a pure PUFA product. Thus “Healthy tasty blend” was better than Kurdola for heart. This completely turned the core value proposition of Kurdola and its extensions. This could lead to serious brand dissonance for the loyal consumer base of Kurdola. The management had to take immediate action in the market as the current positioning and margin structures could lead to serious damage to the brand, cannibalization by low margin products which could drastically reduce the profitability of the company and jeopardize all other businesses.
Conducting psychotherapy with an interpreter
Authors: Kuay Justin , Chopra Prem , Kaplan Ida , Szwarc Josef 
Published: April 2015

Objectives: This qualitative study assessed how clinicians prepared and used interpreters during psychotherapeutic sessions and investigated the strategies they used to manage the dynamics of this process. Methods: Ten therapists were interviewed at the Victorian Foundation for the Survivors of Torture (VFST). A semi-structured interview format was used. Thematic analysis was conducted on transcripts of recorded interviews to identify key themes. Results: Factors affecting the provision of psychotherapy with interpreters agreed with general guidelines for working with interpreters but there were exceptions. The possible roles of the interpreter as a cultural consultant, community advocate and co-therapist were explored. Specific troubleshooting strategies were identified for improving empathy, redefining roles, and adjusting interactions with interpreters. Conclusions: Working with interpreters in psychotherapy is a complex process. These findings may benefit clinicians providing psychotherapy to patients using interpreters.
Using Randomized Controlled Trials to Evaluate Interventions for Releasing Prisoners
Authors: Pettus-Davis Carrie , Howard Matthew Owen , Dunnigan Allison , Scheyett Anna M. , Roberts-Lewis Amelia 
Published: April 2015

Randomized controlled trials (RCTs) are rarely used to evaluate social and behavioral interventions designed for releasing prisoners. Objective: We use a pilot RCT of a social support intervention (Support Matters) as a case example to discuss obstacles and strategies for conducting RCT intervention evaluations that span prison and community contexts. Method: First, we summarize existing studies with current and former prisoner samples that highlight RCT methodological techniques. Then, we introduce the trial of Support Matters and discuss obstacles and efforts to overcome those obstacles. Results and Conclusions: We focus on factors related to sampling frame, participant eligibility, sample size, engagement, and attrition. We conclude with general recommendations related to project delays, compromised research sites, and retention. This article provides guidance based on lessons learned from an RCT of a social support intervention with releasing prisoners and their loved ones. Barriers discussed and recommendations presented here will help interventionists develop and implement RCTs in prison to community contexts.
Designing an Intervention to Promote Child Development Among Fathers With Antisocial Behavior
Authors: Charles Pajarita , Gorman-Smith Deborah , Jones Anne 
Published: April 2015

Objective: This article describes an intervention development focusing on the early design stages of a model to improve psychosocial and behavioral health outcomes among children of fathers with incarceration and antisocial behavioral histories. Method: We use a synthesis of the literature and qualitative interviews with key informants to inform a theoretical model and the next steps in building an intervention. Results: Findings suggest gaps in effective interventions that promote father involvement among men with histories of incarceration and antisocial behavior. Considerations for future interventions include addressing the complex needs of fathers’ post-incarceration, sequencing intervention components using flexible treatment approaches, and employing intentional recruitment and retention strategies. Conclusion: The negative relation between fathers’ imprisonment and antisocial behavior and children’s outcomes calls for interventions to promote positive father involvement. This article proposes a systematized approach to design such an intervention concluding with next steps in the planning for a future intervention study.
Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells
Authors: Villa Nancy Y. , Wasserfall Clive H. , Meacham Amy M. , Wise Elizabeth , Chan Winnie , Wingard John R. , McFadden Grant , Cogle Christopher R. 
Published: April 2015

Key PointsMYXV binds human T lymphocytes but does not enter and infect T cells until after activation. MYXV-infected T lymphocytes proliferate less and secrete less inflammatory cytokines but deliver oncolytic virus to augment GVM.
Employment subsidies, informal economy and women’s transition into work in a depressed area: evidence from a matching approach
Authors: Deidda Manuela , Di Liberto Adriana , Foddi Marta , Sulis Giovanni 
Published: April 2015

Abstract
We analyze the effects of an ALMP for disadvantaged workers implemented in a depressed area of Italy. Using propensity-score matching, we find that a) the employment subsidy had a positive effect for participants on both the probability of finding a job and income, b) the outcome of the policy was more positive for women, and c) the program was more effective for older and less-educated female workers. Using data on previous contacts between workers and firms and on informal channels for job search activity, we ultimately explore the role of the program in promoting the transition from informal to salaried employment.
Changes in labour market transitions in Ireland over the Great Recession: what role for policy?
Authors: Bergin Adele , Kelly Elish , McGuinness Seamus 
Published: April 2015

Abstract
This paper assesses the impact the Great Recession had on individuals’ transitions to and from unemployment in Ireland. The rate of transition from unemployment to employment declined between 2006 and 2011, while the rate from employment to unemployment increased. The results indicate that young people are much less likely to exit unemployment but, at the same time, have a lower risk of becoming unemployed. Education has become an increasingly important factor in supporting unemployment exits and reducing the risk of unemployment since the recession. The findings are supportive of current policies aimed at facilitating access to higher education for unemployed people, but they raise questions with regard to the adequacy of the Youth Guarantee.
In-flight performance of the Absolute Scalar Magnetometer vector mode on board the Swarm satellites
Authors: Léger Jean-Michel , Jager Thomas , Bertrand François , Hulot Gauthier , Brocco Laura , Vigneron Pierre , Lalanne Xavier , Chulliat Arnaud , Fratter Isabelle 
Published: April 2015

Abstract
The role of the Absolute Scalar Magnetometer (ASM) in the European Space Agency (ESA) Swarm mission is to deliver absolute measurements of the magnetic field’s strength for science investigations and in-flight calibration of the Vector Field Magnetometer (VFM). However, the ASM instrument can also simultaneously deliver vector measurements with no impact on the magnetometer’s scalar performance, using a so-called vector mode. This vector mode has been continuously operated since the beginning of the mission, except for short periods of time during commissioning. Since both scalar and vector measurements are perfectly synchronous and spatially coherent, a direct assessment of the ASM vector performance can then be carried out at instrument level without need to correct for the various magnetic perturbations generated by the satellites. After a brief description of the instrument’s operating principles, a thorough analysis of the instrument’s behavior is presented, as well as a characterization of its environment in flight, using an alternative high sampling rate (burst) scalar mode that could be run a few days during commissioning. The ASM vector calibration process is next detailed, with some emphasis on its sensitivity to operational conditions. Finally, the evolution of the instrument’s performance during the first year of the mission is presented and discussed in view of the mission’s performance requirements for vector measurements.