bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implant and Clinical Characteristics for Pediatric and Congenital Heart Patients in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry
Authors: Jordan Christopher P. , Freedenberg Vicki , Wang Yongfei , Curtis Jeptha P. , Gleva Marye J. , Berul Charles I. 
Published: October 2014

Background—
In 2010, the National Cardiovascular Data Registry enhanced pediatric, nonatherosclerotic structural heart disease and congenital heart disease (CHD) data collection. This report characterizes CHD and pediatric patients undergoing implantable cardioverter defibrillator implantation.

Methods and Results—

In this article, we report implantable cardioverter defibrillator procedures (April 2010 to December 2012) in the registry for 2 cohorts: (1) all patients with CHD (atrial septal defect, ventricular septal defect, tetralogy of Fallot, Ebstein anomaly, transposition of the great vessels, and common ventricle) and (2) patients <21 years. We evaluated indications and characteristics to include transvenous and nontransvenous lead implants, CHD type, and New York Heart Association class. There were 3139 CHD procedures, 1601 for patients <21 years and 126 for CHD <21 years. Implantable cardioverter defibrillator indications for patients with CHD were primary prevention in 1943 (61.9%) and secondary prevention in 1107 (35.2%). Pediatric patients had 935 (58.4%) primary prevention and 588 (36.7%) secondary prevention devices. Primary prevention had higher New York Heart Association class. Nontransvenous age (35.9±23.2 versus 40.1±24.6 years;
P
=0.05) and nontransvenous height (167.1±18.9 cm; range, 53–193 cm versus 170.4±13.1 cm; range, 61–203 cm;
P
<0.01) were lower than for transvenous patients. CHD and pediatrics had similar rates of transvenous (97%) and nontransvenous (3%) leads and did not differ from the overall registry. Transposition of the great vessels and common ventricle had higher rates of nontransvenous leads.

Conclusions—
Primary prevention exceeds secondary prevention for CHD and pediatrics. Nontransvenous lead patients were younger, with higher rates of transposition of the great vessels and common ventricle patients compared with transvenous lead patients.
Wireless Pulmonary Artery Pressure Monitoring Guides Management to Reduce Decompensation in Heart Failure With Preserved Ejection Fraction
Authors: Adamson Philip B. , Abraham William T. , Bourge Robert C. , Costanzo Maria Rosa , Hasan Ayesha , Yadav Chethan , Henderson John , Cowart Pam , Stevenson Lynne Warner 
Published: October 2014

Background—
No treatment strategies have been demonstrated to be beneficial for the population for patients with heart failure (HF) and preserved ejection fraction (EF).

Methods and Results—

The CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients (CHAMPION) trial was a prospective, single-blinded, randomized controlled clinical trial testing the hypothesis that hemodynamically guided HF management decreases decompensation leading to hospitalization. Of the 550 patients enrolled in the study, 119 had left ventricular EF ≥40% (average, 50.6%), 430 patients had low left ventricular EF (<40%; average, 23.3%), and 1 patient had no documented left ventricular EF. A microelectromechanical system pressure sensor was permanently implanted in all participants during right heart catheterization. After implant, subjects were randomly assigned in single-blind fashion to a treatment group in whom daily uploaded pressures were used in a treatment strategy for HF management or to a control group in whom standard HF management included weight-monitoring, and pressures were uploaded but not available for investigator use. The primary efficacy end point of HF hospitalization rate >6 months for preserved EF patients was 46% lower in the treatment group compared with control (incidence rate ratio, 0.54; 95% confidence interval, 0.38–0.70;
P
<0.0001). After an average of 17.6 months of blinded follow-up, the hospitalization rate was 50% lower (incidence rate ratio, 0.50; 95% confidence interval, 0.35–0.70;
P
<0.0001). In response to pulmonary artery pressure information, more changes in diuretic and vasodilator therapies were made in the treatment group.

Conclusions—
Hemodynamically guided management of patients with HF with preserved EF reduced decompensation leading to hospitalization compared with standard HF management strategies.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00531661.
Renal Hemodynamic Effects of Serelaxin in Patients With Chronic Heart Failure
Authors: Voors Adriaan A. , Dahlke Marion , Meyer Sven , Stepinska Janina , Gottlieb Stephen S. , Jones Andrew , Zhang Yiming , Laurent Didier , Slart Riemer H.J.A. , Navis Gerjan J. 
Published: October 2014

Background—
Serelaxin is a promising therapy for acute heart failure. The renal hemodynamic effects of serelaxin in patients with chronic heart failure are unknown.

Methods and Results—

In this double-blind, randomized, placebo-controlled, multicenter study, patients with New York Heart Association Class II to III chronic heart failure, left ventricular ejection fraction ≤45%, and estimated glomerular filtration rate (GFR) 30 to 89 mL/min per 1.73 m
2
received intravenous serelaxin 30 μg/kg per day or placebo for 24 hours. Primarily, we assessed the difference between serelaxin and placebo on renal plasma flow (para-aminohippuric acid clearance) and GFR (iothalamate clearance) over 8 to 24 hours. All 22 patients from 1 clinical site were excluded from primary analyses before unblinding because of implausible measurements. The primary analysis comprised 65 patients, mean age was 68 (±10) years, 89% were male, mean estimated GFR was 64 (±19) mL/min per 1.73 m
2
, and 34% had New York Heart Association Class III symptoms. Renal plasma flow increased by 29% with serelaxin and 14% with placebo (13% relative increase with serelaxin;
P
=0.0386), whereas GFR changes did not differ significantly during 8 to 24 hours. Filtration fraction increased by 36% with serelaxin and 62% with placebo (16% relative decrease with serelaxin;
P
=0.0019) during 8 to 24 hours. Changes in systolic blood pressure were largely similar, and creatinine clearance did not differ between groups. Adverse event rates were similar with serelaxin (20.5%) and placebo (25.0%).

Conclusions—
In patients with chronic heart failure, serelaxin increased renal plasma flow and reduced the increase in filtration fraction compared with placebo, but did not affect GFR. These results suggest beneficial renal hemodynamic effects in patients with chronic heart failure.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01546532.
Impact of Atmosphere and Land Surface Initial Conditions on Seasonal Forecasts of Global Surface Temperature
Authors: Materia Stefano , Borrelli Andrea , Bellucci Alessio , Alessandri Andrea , Di Pietro Pierluigi , Athanasiadis Panagiotis , Navarra Antonio , Gualdi Silvio 
Published: October 2014

Abstract
The impact of land surface and atmosphere initialization on the forecast skill of a seasonal prediction system is investigated, and an effort to disentangle the role played by the individual components to the global predictability is done, via a hierarchy of seasonal forecast experiments performed under different initialization strategies. A realistic atmospheric initial state allows an improved equilibrium between the ocean and overlying atmosphere, increasing the model predictive skill in the ocean. In fact, in regions characterized by strong air–sea coupling, the atmosphere initial condition affects forecast skill for several months. In particular, the ENSO region, eastern tropical Atlantic, and North Pacific benefit significantly from the atmosphere initialization. On the mainland, the effect of atmospheric initial conditions is detected in the early phase of the forecast, while the quality of land surface initialization affects forecast skill in the following seasons. Winter forecasts in the high-latitude plains benefit from the snow initialization, while the impact of soil moisture initial state is particularly effective in the Mediterranean region and central Asia.
However, the initialization strategy based on the full value technique may not be the best choice for land surface, since soil moisture is a strongly model-dependent variable: in fact, initialization through land surface reanalysis does not systematically guarantee a skill improvement. Nonetheless, using a different initialization strategy for land, as opposed to atmosphere and ocean, may generate inconsistencies. Overall, the introduction of a realistic initialization for land and atmosphere substantially increases skill and accuracy. However, further developments in the procedure for land surface initialization are required for more accurate seasonal forecasts.
Influence of SST Anomalies on Winter Turbulent Heat Fluxes in the Eastern Kuroshio–Oyashio Confluence Region
Authors: Sugimoto Shusaku 
Published: October 2014

Abstract
Variations in the turbulent heat flux (THF; the sum of the sensible and latent heat fluxes) in the eastern Kuroshio–Oyashio confluence region (EKOCR; 36°–40°N, 155°–160°E) were investigated over a period of 27 consecutive winters (December–February) from 1985/86 to 2011/12. The THF was calculated from a bulk formula using daily variables [surface wind speed, surface air specific humidity, surface air temperature, and sea surface temperature (SST)] of the objectively analyzed air–sea fluxes (OAFlux) dataset and bulk coefficients based on the Tropical Ocean and Global Atmosphere Coupled Ocean–Atmosphere Response Experiment (TOGA COARE) bulk flux algorithm 3.0. The winter THF over the EKOCR showed low-frequency variations, with larger THF values in the early 2000s and smaller values in the late 1990s and late 2000s. The heat release in the early 2000s was up to ~40% greater than that in the late 1990s and late 2000s. By performing experiments using combinations of daily raw data values and daily climatological data, the relative contributions of SST, surface air specific humidity, surface air temperature, and surface wind speed were quantitatively assessed in determining the THF over the EKOCR. Results showed that SST predominantly determines the THF: large amounts of heat are released during times of positive SST anomalies. By using Argo float (temperature–salinity) profiles of 2003–12 and a satellite altimetry dataset of 1992–2012, it was found that the warm–salty water transported by an occurrence of the Kuroshio bifurcation was responsible for the generation of positive SST anomalies in the EKOCR.
On the Variability of Antarctic Circumpolar Current Fronts Inferred from 1992–2011 Altimetry*
Authors: Kim Yong Sun , Orsi Alejandro H. 
Published: October 2014

Abstract
Antarctic Circumpolar Current (ACC) fronts, defined as water mass boundaries, have been known to respond to large-scale atmospheric variabilities, especially the Southern Hemisphere annular mode (SAM) and El Niño–Southern Oscillation (ENSO). Distinct patterns of localized variability in meridional front displacements during 1992–2011 are derived from the analysis of satellite sea surface height data. Major basin-scale differences are found between the southeast Pacific (150°–90°W) and the southeast Indian (75°–150°E) sectors of the ACC. Frontal positions in the southeast Pacific show large year-to-year meridional fluctuations, attributed mostly to ENSO and in part SAM, and no apparent seasonal cycles or long-term trends. In contrast, summer (winter) frontal locations in the southeast Indian extend farther to the south (north) of their long-term mean distribution. A southward drift of ACC fronts is indicated over the Indian sector during the past two decades. This long-term shift is not directly related to the atmospheric variabilities, but this is most likely in response to changes in large-scale ocean circulation, in particular to the poleward expansion of the Indian subtropical gyre. The existence of these localized, contrasting variability patterns suggests that a circumpolar-averaging analysis could possibly smooth out a local climate signal, with an emphasis on a basin-scale investigation for climate studies in the Southern Ocean.
Medication-overuse headache in China: Clinical profile, and an evaluation of the ICHD-3 beta diagnostic criteria
Authors: Dong Zhao , Chen Xiaoyan , Steiner Timothy J , Hou Lei , Di Hai , He Mianwang , Dai Wei , Pan Meiyan , Zhang Mingjie , Liu Ruozhuo , Yu Shengyuan 
Published: October 2014

Background Although medication-overuse headache (MOH) is common in China, its clinical profile is not yet fully established. Meanwhile, ICHD-3 beta has been published, but its diagnostic criteria require further validation. Methods We retrospectively classified the clinical features of 240 consecutive patients with MOH (55 males, 185 females), whose demographic data, headache features, overused medications (type, quantity, frequency and duration of use), headache-attributed burden, and outcomes were reviewed. We then applied the criteria of the several versions of ICHD (II, IIR and 3-beta) to these patients. Results Compared with those with other headaches, patients with MOH were more likely to be less well educated (64.6% vs 42.0% for secondary school or lower, p < 0.0001), and on lower annual incomes (72.3% vs 56.0% for an income of Chinese yuan (CNY) 30,000 or less, p < 0.0001). Combination analgesics were the most commonly overused medications, and, caffeine (89.9%), aminopyrine (70.0%), phenacetin (53.9%) and phenobarbital (48.8%) were the most commonly used specific components of these. Only two patients (0.8%) had previously been given the diagnosis of MOH; accordingly, the median time to diagnosis after the estimated onset of the disorder was 4.0 years. The majority of patients (83.7%) improved with treatment. All 240 patients fulfilled the diagnostic criteria for MOH according to ICHD-3 beta; only 134 (55.8%) satisfied the diagnostic criteria for definite MOH according to ICHD-II, while 195 (81.2%) met those of ICHD-IIR. Conclusions MOH in China is associated with lower educational level and annual income. MOH has rarely been diagnosed and correctly treated in China. ICHD-3 beta appears to be more appropriate for the diagnosis of MOH than previous versions.
Antioxidant N-acetyl-l-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice
Authors: Hu Linping , Cheng Hui , Gao Yingdai , Shi Ming , Liu Yanfeng , Hu Zheng , Xu Jing , Qiu Lugui , Yuan Weiping , Leung Anskar Yu-Hung , Yang Yong-Guang , Cheng Tao 
Published: October 2014

Key Points
NAC increases engraftment of human hematopoietic stem cells in immunodeficient mice.
Assembling single gold nanorods into large-scale highly aligned nanoarrays via vacuum-enhanced capillarity
Authors: Wang Jiaojiao , Li Min , Tang Bochong , Xie Peng , Ma Lei , Hu Zhongbo , Zhao Yuliang , Wei Zhongqing 
Published: October 2014

Abstract
We report a simple, straightforward, and efficient approach to assemble single gold nanorods (AuNRs) into highly aligned arrays, via a unique vacuum-enhanced capillarity. The assembled AuNR arrays demonstrate both an excellently unidirectional ordering and a wonderful single-rod resolution. The key role of vacuum in this approach enables high-aspect-ratio (10 to 22) AuNR alignment and efficiently facilitates large-area alignment. Further investigation of one- and two-dimensional AuNR arrays would undoubtedly be beneficial to their potential applications.
TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients
Authors: Fernandez Sandra V , Bingham Catherine , Fittipaldi Patricia , Austin Laura , Palazzo Juan , Palmer Gary , Alpaugh Katherine , Cristofanilli Massimo 
Published: October 2014

Abstract
Introduction
Circulating tumor cells (CTCs) are tumor cells shed from either primary tumors or its metastases that circulate in the peripheral blood of patients with metastatic cancers. The molecular characterization of the CTCs is critical to identifying the key drivers of cancer metastasis and devising therapeutic approaches. However, the molecular characterization of CTCs is difficult to achieve because their isolation is a major technological challenge.

Methods
CTCs from two triple negative breast cancer patients were enriched using CellSearch and single cells selected by DEPArray™. A TP53 R110 fs*13 mutation identified by next generation sequencing in the breast and chest skin biopsies of both patients was studied in single CTCs.

Results
From 6 single CTC isolated from one patient, 1 CTC had TP53 R110 delC, 1 CTC showed the TP53 R110 delG mutation, and the remaining 4 single CTCs showed the wild type p53 sequence; a pool of 14 CTCs isolated from the same patient also showed TP53 R110 delC mutation. In the tumor breast tissue of this patient, only the TP53 R110 delG mutation was detected. In the second patient a TP53 R110 delC mutation was detected in the chest wall skin biopsy; from the peripheral blood of this patient, 5 single CTC and 6 clusters of 2 to 6 CTCs were isolated; 3 of the 5 single CTCs showed the TP53 R110 delC mutation and 2 CTCs showed the wild type TP53 allele; from the clusters, 5 showed the TP53 R110 delC mutation, and 1 cluster the wild type TP53 allele. Single white blood cells isolated as controls from both patients only showed the wild type TP53 allele.

Conclusions
We are able to isolate uncontaminated CTCs and achieve single cell molecular analysis. Our studies showed the presence of different CTC sub-clones in patients with metastatic breast cancer. Some CTCs had the same TP53 mutation as their matching tumor samples although others showed either a different TP53 mutation or the wild type allele. Our results indicate that CTCs could represent a non-invasive source of cancer cells from which to determine genetic markers of the disease progression and potential therapeutic targets.
Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I
Authors: Warwick Jane , Birke Hanna , Stone Jennifer , Warren Ruth ML , Pinney Elizabeth , Brentnall Adam R , Duffy Stephen W , Howell Anthony , Cuzick Jack 
Published: October 2014

Abstract
Introduction
Mammographic density is well-established as a risk factor for breast cancer, however, adjustment for age and body mass index (BMI) is vital to its clinical interpretation when assessing individual risk. In this paper we develop a model to adjust mammographic density for age and BMI and show how this adjusted mammographic density measure might be used with existing risk prediction models to identify high-risk women more precisely.

Methods
We explored the association between age, BMI, visually assessed percent dense area and breast cancer risk in a nested case-control study of women from the placebo arm of the International Breast Cancer Intervention Study I (72 cases, 486 controls). Linear regression was used to adjust mammographic density for age and BMI. This adjusted measure was evaluated in a multivariable logistic regression model that included the Tyrer-Cuzick (TC) risk score, which is based on classical breast cancer risk factors.

Results
Percent dense area adjusted for age and BMI (the density residual) was a stronger measure of breast cancer risk than unadjusted percent dense area (odds ratio per standard deviation 1.55 versus 1.38; area under the curve (AUC) 0.62 versus 0.59). Furthermore, in this population at increased risk of breast cancer, the density residual added information beyond that obtained from the TC model alone, with the AUC for the model containing both TC risk and density residual being 0.62 compared to 0.51 for the model containing TC risk alone (P =0.002).
Approximately 16% of controls and 19% of cases moved into the highest risk group (8% or more absolute risk of developing breast cancer within 10 years) when the density residual was taken into account. The net reclassification index was +15.7%.

Conclusions
In women at high risk of breast cancer, adjusting percent mammographic density for age and BMI provides additional predictive information to the TC risk score, which already incorporates BMI, age, family history and other classic breast cancer risk factors. Furthermore, simple selection criteria can be developed using mammographic density, age and BMI to identify women at increased risk in a clinical setting.

Clinical trial registration number
http://www.controlled-trials.com/ISRCTN91879928 (Registered: 1 June 2006).
Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration
Authors: Marfia Giovanni , Campanella Rolando , Navone Stefania Elena , Zucca Ileana , Scotti Alessandro , Figini Matteo , Di Vito Clara , Alessandri Giulio , Riboni Laura , Parati Eugenio 
Published: October 2014

Abstract
Introduction
Biglycan is an important proteoglycan of the extracellular matrix of intervertebral disc (IVD), and its decrease with aging has been correlated with IVD degeneration. Biglycan deficient (Bgn−/0) mice lack this protein and undergo spontaneous IVD degeneration with aging, thus representing a valuable in vivo model for preliminary studies on therapies for human progressive IVD degeneration. The purpose of the present study was to assess the possible beneficial effects of adipose-derived stromal cells (ADSCs) implants in the Bgn−/0 mouse model.

Methods
To evaluate ADSC implant efficacy, Bgn−/0 mice were intradiscally (L1-L2) injected with 8x104 ADSCs at 16 months old, when mice exhibit severe and complete IVD degeneration, evident on both 7Tesla Magnetic Resonance Imaging (7TMRI) and histology. Placebo and ADSCs treated Bgn−/0 mice were assessed by 7TMRI analysis up to 12 weeks post-transplantation. Mice were then sacrificed and implanted discs were analyzed by histology and immunohistochemistry for the presence of human cells and for the expression of biglycan and aggrecan in the IVD area.

Results
After in vivo treatment, 7TMRI revealed evident increase in signal intensity within the discs of mice that received ADSCs, while placebo treatment did not show any variation. Ultrastructural analyses demonstrated that human ADSC survival occurred in the injected discs up to 12 weeks after implant. These cells acquired a positive expression for biglycan, and this proteoglycan was specifically localized in human cells. Moreover, ADSC treatment resulted in a significant increase of aggrecan tissue levels.

Conclusion
Overall, this work demonstrates that ADSC implant into degenerated disc of Bgn−/0 mice ameliorates disc damage, promotes new expression of biglycan and increased levels of aggrecan. This suggests a potential benefit of ADSC implant in the treatment of chronic degenerative disc disease and prompts further studies in this field.