bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drivers of the natural long-term rate of interest (and why the economy hasn’t tanked)
Authors: Ademmer Martin , Rush Jamie 
Published: July 2024

Abstract
Long-term borrowing costs have been on a path of near continuous decline for the last several decades, with huge consequences for asset values, government finances, borrowers and savers. To shed light on why, we have estimated a global model that brings together an extensive set of drivers of the natural rate of interest for 12 advanced economies, using data spanning half a century. We find that slower growth and the age structure of the population accounted for about half of the three percentage point decline in the real natural rate for the USA between 1970 and a trough in the mid-2010s. Global spillovers account for a bit more than a third of the decline. Our model suggests the natural rate in the USA has climbed more than half a percentage point since the trough, partly reflecting extraordinary fiscal stimulus in the USA. Rather than on overnight rates, our model is estimated on 10-year borrowing costs. That is because monetary policy has increasingly relied on squeezing the whole yield curve to support demand. Importantly, when viewed through a longer-term lens, US monetary policy does not look as tight as it does when looking at short-term rates alone. This may help to explain why the economy has been so resilient to the post-pandemic hiking cycle.
Experimental Constraints on the Storage Conditions and Differentiation of High-Ti Basalts from the Panzhihua and Hongge Layered Intrusions, SW China
Authors: Wang Dachuan , Hou Tong , Botcharnikov Roman , Haselbach Sarah , Pohl Florian , Almeev Renat R , Klügel Andreas , Wang Meng , Qin Jingyi , Zhang Zhaochong , Holtz Francois 
Published: July 2024

Abstract
High-Ti basalts are commonly believed to represent parental magmas leading to the formation of mafic-ultramafic layered intrusions, such as Late Permian Panzhihua and Hongge in the Emeishan Large Igneous Province (SW China). Consequently, elucidation of the crystallisation and crustal differentiation of high-Ti basalts is critical for our understanding of the petrogenesis of these layered intrusions and the associated oxide ore mineralisation. Here, we present the results of crystallisation experiments carried out in internally heated pressure vessels using a primitive high-Ti basaltic composition. The experiments were conducted at 100 and 300 MPa, in the temperature interval of 950–1200 °C and with water activities (aH2O) from 0 to 1. The oxygen fugacity (fO2) was controlled and varied from FMQ −1 to FMQ +3.3 log units (FMQ corresponds to fayalite-quartz-magnetite buffer). The main mineral phases are olivine, clinopyroxene and plagioclase, accompanied by Cr-Fe-Ti-oxides, orthopyroxene, apatite and amphibole, depending on the conditions. Redox conditions primarily influence the stability fields of Cr-Fe-Ti oxides. Clinopyroxene, orthopyroxene and amphibole are pressure-dependent and have larger stability fields under high pressure conditions. The olivine→orthopyroxene and olivine→amphibole peritectic reactions are observed. Comparisons of phase equilibria between this study and experiments conducted with parental magma of Skaergaard layered intrusion demonstrate the effect of bulk system composition. For instance, ilmenite crystallisation is determined not only by intrinsic parameters such as fO2 but also by additional compositional parameters (e.g. melt Ti, Fe, Al and Mg content). Although COMAGMAT and MELTS modelling results generally reproduce the crystallisation sequence, only the stability field of clinopyroxene and its composition are perfectly modelled. The comparison of experimental results with the rocks from the lowest units of Panzhihua and Hongge layered intrusions are applied to constrain storage conditions in the magma reservoirs. Compared to Hongge, we conclude that the Panzhihua magma chamber was probably located at a shallower depth (~3–6 km), that magma crystallisation started at lower temperatures (~1125–1100 °C), higher fO2 (~FMQ + 1 to FMQ + 2) and that its initial melt H2O content was lower (~0.5–1 wt. %).
Effects of firebricks for industrial process heat on the cost of matching all-sector energy demand with 100% wind–water–solar supply in 149 countries
Authors: Jacobson Mark Z , Sambor Daniel J , Fan Yuanbei F , Mühlbauer Andreas 
Published: July 2024

AbstractRefractory bricks are bricks that can withstand high temperatures without damage to their structures. They have been used to insulate kilns, furnaces, and other hot enclosures for thousands of years. Firebricks are refractory bricks that can, with one composition, store heat, and with another, insulate the firebricks that store the heat. Because firebricks are made from common materials, the cost per kilowatt-hour-thermal of a firebrick storage system is less than one-tenth the cost per kilowatt-hour-electricity of a battery system. It has thus been hypothesized that using excess renewable electricity to produce and store industrial process heat in firebricks can provide a low-cost source of continuous heat for industry. Here, it is hypothesized further that, upon a transition to 100% clean, renewable energy worldwide, using firebricks to store industrial process heat can reduce electricity generator, electricity storage, and low-temperature heat storage needs, thereby reducing overall energy cost. Both hypotheses are tested across 149 countries combined into 29 world regions. Results suggest, relative to a base case with no firebricks, using firebricks may reduce, among all 149 countries, 2050 battery capacity by ∼14.5%, annual hydrogen production for grid electricity by ∼31%, underground low-temperature heat storage capacity by ∼27.3%; onshore wind nameplate capacity by ∼1.2%, land needs by ∼0.4%, and overall annual energy cost by ∼1.8%. In sum, the use of firebricks for storing industrial process heat appears to be a remarkable tool in reducing the cost of transitioning to clean, renewable energy across all energy sectors.
Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade
Authors: Du Yuhui , Niu Ju , Xing Ying , Li Bang , Calhoun Vince D 
Published: July 2024

Abstract

Background and Hypothesis
Schizophrenia (SZ) is characterized by significant cognitive and behavioral disruptions. Neuroimaging techniques, particularly magnetic resonance imaging (MRI), have been widely utilized to investigate biomarkers of SZ, distinguish SZ from healthy conditions or other mental disorders, and explore biotypes within SZ or across SZ and other mental disorders, which aim to promote the accurate diagnosis of SZ. In China, research on SZ using MRI has grown considerably in recent years.

Study Design
The article reviews advanced neuroimaging and artificial intelligence (AI) methods using single-modal or multimodal MRI to reveal the mechanism of SZ and promote accurate diagnosis of SZ, with a particular emphasis on the achievements made by Chinese scholars around the past decade.

Study Results
Our article focuses on the methods for capturing subtle brain functional and structural properties from the high-dimensional MRI data, the multimodal fusion and feature selection methods for obtaining important and sparse neuroimaging features, the supervised statistical analysis and classification for distinguishing disorders, and the unsupervised clustering and semi-supervised learning methods for identifying neuroimage-based biotypes. Crucially, our article highlights the characteristics of each method and underscores the interconnections among various approaches regarding biomarker extraction and neuroimage-based diagnosis, which is beneficial not only for comprehending SZ but also for exploring other mental disorders.

Conclusions
We offer a valuable review of advanced neuroimage analysis and AI methods primarily focused on SZ research by Chinese scholars, aiming to promote the diagnosis, treatment, and prevention of SZ, as well as other mental disorders, both within China and internationally.
Evaluating Reduced Blood Monitoring Frequency and the Detection of Hematological Abnormalities in Clozapine-Treated Patients With Schizophrenia: A Chart Review Study From the COVID-19 Pandemic
Authors: Thai Helen , Preobrazenski Nicholas , Hsieh TiChen , Robertson Carrie , Owoeye Olabisi 
Published: July 2024

Abstract

Background and Hypothesis
In response to Health Canada’s March 2020 directive, patients on clozapine for over 12 months were allowed to extend hematological testing intervals from 4 to 8 weeks during the COVID-19 pandemic. We hypothesized that this change would not affect the timely detection of hematological abnormalities in patients with severe mental illness.

Study Design
A chart review was conducted of patients at the Royal Ottawa who were prescribed clozapine from March 2019 to March 2021. We analyzed clinical and hematological data from electronic health records and Clozaril Support and Assistance Network database to compare occurrences of hematological abnormalities [leukopenia (white blood cell count &lt;3.5 × 109/L) and agranulocytosis (absolute neutrophil count &lt;0.5 × 109/L)] from March 17, 2020 to March 16, 2021, between standard and extended monitoring protocols using binomial logistic and zero-inflated negative binomial regressions.

Study Results
Of 621 patients, 196 were on extended blood monitoring, and 425 followed standard blood monitoring. Clozapine dose did not differ between groups (standard: 370 ± 201 mg; extended: 352 ± 172 mg; P = .14, ds = 0.10). Clozapine treatment duration up to March 2021 was 12.6 ± 8.3 years, with the extended group (10 ± 7.9 years) having a significantly (P &lt; .01, ds = 0.50) shorter duration than the standard (14 ± 8.2 years). Extended monitoring did not significantly impact likelihood of detecting hematological abnormalities (OR = 0.83, 95% CI [0.58,1.41], P = .55) after controlling for age, sex, total bloodwork, and other psychotropics associated with neutrophil counts (ie, valproate, olanzapine). No patient on the extended regimen developed agranulocytosis.

Conclusions
Reducing blood monitoring frequency in patients on clozapine for more than 12 months did not compromise detection of hematological abnormalities.
US AI data centers and deployment challenges for small modular reactors: proposed regulatory policy recommendations
Authors: Hemphill Thomas A 
Published: July 2024

Abstract
Global demand by cloud vendors, financial institutions, and telecommunication companies for commercially owned and operated data centers is accelerating in recent years. Given this increase in energy supply required to meet US artificial intelligence (AI) technology consumer demand, the paper addresses state-of-the-art traditional data centers and their capacity transition to process AI technologies. Subsequently, the paper explains the potential for small modular (nuclear) reactors—and specifically a subset, micro modular reactors (MMRs)—to generate the increasing energy demanded for AI processing capabilities, including the potential of quantum computing, through 2035 and beyond. Lastly, the paper identifies a primary regulatory policy challenge—the federal regulatory construction review/permitting process—that hinders an environmentally sustainable source of nuclear energy to power such AI data centers and offers policy recommendations to assist in meeting this federal regulatory policy challenge and encourages the deployment of MMR technologies.
Signaling virtue or vulnerability? The changing impact of EMU on government bond spreads
Authors: Barta Zsófia , Baccaro Lucio , Johnston Alison 
Published: July 2024

Abstract
Do bond-spreads of developed countries behave differently under different exchange-rate regimes? Focusing on the experience of European monetary integration, we find that the impact of exchange-rate regimes on spreads depends on the macroeconomic context. When inflation counted as the greatest risk to bondholdings, Economic and Monetary Union (EMU) was advantaged over flexible and fixed exchange rates, because of its in-built inflation-control mechanisms. Since debt-sustainability became the primary risk, exchange-rate rigidity has been a liability because it constrains governments’ response to adverse shocks. Employing a moving-window analysis for 12 EMU-members plus 10 ‘comparators’, we find that inflation was penalized under flexible and fixed exchange-rate regimes, but not under EMU. From the early 2010s on, inflation carried no penalty under any exchange-rate regime. Debt and deficit did not affect spreads until the late 2000s. Since then, EMU-members incurred larger and more prolonged spreads penalties for deficits and debt than countries in other exchange-rate regimes.
Advances in the study of the relationship between gut microbiota and erectile dysfunction
Authors: Su Quanxin , Tang Qizhen , Ma Chuanyu , Wang Kenan 
Published: July 2024

Abstract

Introduction
In recent years, in-depth research has revealed that gut microbiota has an inseparable relationship with erectile dysfunction (ED) in men.

Objectives
(1) To review the correlation between gut microbiota and ED from the perspective of its impact on men’s mental health, metabolism, immunity, and endocrine regulation and (2) to provide reference to further explore the pathogenesis of ED and the improvement of clinical treatment plans.

Methods
PubMed was used for the literature search to identify publications related to ED and gut microbiota.

Results
Gut microbiota may induce depression and anxiety through the microbiota-gut-brain axis, leading to the occurrence of psychological ED. It may also cause vascular endothelial dysfunction and androgen metabolism disorder by interfering with lipid metabolism, immunity, and endocrine regulation, leading to the occurrence of organic ED.

Conclusion
Gut microbiota and its metabolites play an important role in the occurrence and development of ED. As a new influencing factor of ED, gut microbiota disorder is expected to become a target for treatment.
Knockdown of circ_0076305 decreases the paclitaxel resistance of non-small cell lung cancer cells by regulating TMPRSS4 via miR-936
Authors: Su Lin , Gou Jiaxue , Zhou Chunyan , Li Jieping , Wu Jing , Shen Lili , Jia Yimin 
Published: July 2024

Abstract

Background
Paclitaxel (PTX) is a commonly used as a chemotherapeutic drug for non-small cell lung cancer (NSCLC). Exploring the underlying mechanism of PTX resistance is of great significance for NSCLC treatment.

Methods
The expression levels of RNA and protein were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot assays. The targeted relationship was confirmed by dual-luciferase reporter assay and RNA-pull down assay. The PTX resistance and cell proliferation were assessed by cell counting kit-8 (CCK-8) assay and 5-Ethynyl-2′-deoxyuridine (EDU) assay, respectively. Cell migration and invasion were analyzed by transwell assays. Cell apoptosis was analyzed by flow cytometry, and cell glycolysis was analyzed using the commercial kits. The role of circular RNA_0076305 (circ_0076305) in regulating the PTX sensitivity in vivo was explored in xenograft tumor model.

Results
Circ_0076305 was up-regulated in PTX-resistant NSCLC tissues and cells. Mechanically, circ_0076305 bound to microRNA-936 (miR-936), and miR-936 targeted transmembrane serine protease 4 (TMPRSS4). Circ_0076305 could up-regulate TMPRSS4 expression by sponging miR-936 in NSCLC cells. miR-936 knockdown or TMPRSS4 overexpression reversed the anti-tumor effects of circ_0076305 knockdown in NSCLC cells with PTX treatment. Circ_0076305 silencing increased the PTX sensitivity of xenograft tumors in vivo.

Conclusion
Circ_0076305 silencing promoted PTX sensitivity by targeting miR-936/TMPRSS4 axis in NSCLC cells.
L-carnitine: A novel approach in management of acute cholinesterase inhibitor insecticide poisoning
Authors: Ragab Hisham Elsayed , El-Banna Asmaa , Elshaer Noha Selim , Azzaz Omnia 
Published: July 2024

AbstractCholinesterase inhibitors (ChEIs) insecticide poisoning is a serious global health concern that results in hundreds of thousands of fatalities each year. Although inhibition of the cholinesterase enzyme is the main mechanism of ChEI poisoning, oxidative stress is considered the mechanism underlying the related complications. The study aimed to assess the oxidative status of the patients with ChEI insecticide poisoning and the role of L-carnitine as adjuvant therapy in their management. Human studies on the efficacy and safety of L-carnitine in treating insecticide poisoning are limited despite its growing research interest as a safe antioxidant. This prospective study was conducted on eighty patients with acute ChEIs insecticide poisoning admitted to Alexandria Poison Center, Alexandria Main University Hospital, Egypt. Patients were allocated into two equal groups randomly. The L-carnitine (LC) group received the conventional treatment (atropine & toxogonin) and LC and the standard treatment (ST) group received the standard treatment only. Outcome measures were fatality rate, the total administered dose of atropine & toxogonin, length of hospital stay, and the requirement for ICU admission or mechanical ventilation. The study results revealed that malondialdehyde (MDA) significantly decreased in the LC group. Cholinesterase enzyme levels increased significantly after treatment in the LC group than in the ST group. The LC group needed lower dosages of atropine and toxogonin than the ST group. Also, the LC group showed no need for ICU admission or mechanical ventilation. The study concluded that LC can be considered a promising adjuvant antioxidant treatment in acute ChEIs pesticide poisoning.
The role of reactive oxygen species in regulation of the plasma membrane H+-ATPase activity in Masson pine (Pinus massoniana Lamb.) roots responding to acid stress
Authors: Zhou Sijie , Wang Wenxin , Wang Ping , Ma Huiyan , Li Wenhui 
Published: July 2024

Abstract
To understand the role of reactive oxygen species (ROS) in regulation of the plasma membrane (PM) H+-ATPase in acid-stressed Masson pine roots, different acidity (pH 6.6 as the control, pH 5.6 and pH 4.6) of simulated acid rain (SAR) added with and without external chemicals (H2O2, enzyme inhibitors and ROS scavenger) was prepared. After 30 days of SAR exposure, the plant morphological phenotype attributes, levels of cellular ROS and lipid peroxidation, enzymatic activities of antioxidants, PM nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and PM H+-ATPase activity in pine seedlings were measured. Compared with the control, the growth of pine seedlings exposed to SAR in the presence or absence of H2O2 was well-maintained, but the application of Na3VO4, 1,3-dimethyl-2-thiourea, N, N-dimethylthiourea (DMTU) and diphenyleneiodonium chloride (DPI) caused a substantial growth inhibition. In addition, SAR exposure, SAR with H2O2 treatment, and SAR with Na3VO4 treatment increased the cellular H2O2 content, O2− content and malondialdehyde (MDA) content, while the use of DMTU and DPI lead to relatively low levels. Similarly, the enzymatic activities of antioxidants, PM NADPH oxidase and PM H+-ATPase in acid stressed pine seedlings elevated with the increasing acidity. A significant stimulation of these enzymatic activities obtained from SAR with H2O2 treatment was observed, whereas which decreased obviously with the addition of Na3VO4, DMTU and DPI (P &lt; 0.05). Moreover, a positive correlation was found between plant morphological attributes and the PM H+-ATPase activity (P &lt; 0.05). Besides, the PM H+-ATPase activity positively correlated with the cellular ROS contents and the enzymatic activities of antioxidants and PM NADPH oxidase (P &lt; 0.05). Therefore, the PM H+-ATPase is instrumental in the growth of pine seedlings resisting to acid stress by enhancing its activity. The process involves the signaling transduction of cellular ROS and coordination with PM NADPH oxidase.
Antiretroviral drug dolutegravir induces inflammation at the mouse brain barriers
Authors: Huang Chang , Hoque Md. Tozammel , Qu Qing Rui , Henderson Jeffrey , Bendayan Reina 
Published: July 2024

AbstractIntegrase strand transfer inhibitors (INSTIs) based antiretroviral therapy (ART) is currently used as first‐line regimen to treat HIV infection. Despite its high efficacy and barrier to resistance, ART‐associated neuropsychiatric adverse effects remain a major concern. Recent studies have identified a potential interaction between the INSTI, dolutegravir (DTG), and folate transport pathways at the placental barrier. We hypothesized that such interactions could also occur at the two major blood–brain interfaces: blood‐cerebrospinal fluid barrier (BCSFB) and blood–brain barrier (BBB). To address this question, we evaluated the effect of two INSTIs, DTG and bictegravir (BTG), on folate transporters and receptor expression at the mouse BCSFB and the BBB in vitro, ex vivo and in vivo. We demonstrated that DTG but not BTG significantly downregulated the mRNA and/or protein expression of folate transporters (RFC/SLC19A1, PCFT/SLC46A1) in human and mouse BBB models in vitro, and mouse brain capillaries ex vivo. Our in vivo study further revealed a significant downregulation in Slc19a1 and Slc46a1 mRNA expression at the BCSFB and the BBB following a 14‐day DTG oral treatment in C57BL/6 mice. However, despite the observed downregulatory effect of DTG in folate transporters/receptor at both brain barriers, a 14‐day oral treatment of DTG‐based ART did not significantly alter the brain folate level in animals. Interestingly, DTG treatment robustly elevated the mRNA and/or protein expression of pro‐inflammatory cytokines and chemokines (Cxcl1, Cxcl2, Cxcl3, Il6, Il23, Il12) in primary cultures of mouse brain microvascular endothelial cells (BBB). DTG oral treatment also significantly upregulated proinflammatory cytokines and chemokine (Il6, Il1β, Tnfα, Ccl2) at the BCSFB in mice. We additionally observed a downregulated mRNA expression of drug efflux transporters (Abcc1, Abcc4, and Abcb1a) and tight junction protein (Cldn3) at the CP isolated from mice treated with DTG. Despite the structural similarities, BTG only elicited minor effects on the markers of interest at both the BBB and BCSFB. In summary, our current data demonstrates that DTG but not BTG strongly induced inflammatory responses in a rodent BBB and BCSFB model. Together, these data provide valuable insights into the mechanism of DTG‐induced brain toxicity, which may contribute to the pathogenesis of DTG‐associated neuropsychiatric adverse effect.