bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental study of the anti-inflammatory activity of diclofenac in ultra-low doses on a model of acute carrageenan inflammation
Authors: Makhmudova O. A. , Avkhadieva G. F. , Khaziakhmetova V. N. , Nikitin D. O. , Semina I. I. 
Published: August 2024

Relevance. Drug pollution of the environment is a global environmental problem of our time. Increased consumption of medicines directly affects the level of pollution of various ecosystems, including water resources. The insufficient efficiency of existing methods for treating wastewater from drugs leads to drug pollution of water bodies and requires studying the effect of ultra-low doses of drugs on the human body and animals. A non-steroidal antiinflammatory drug, diclofenac, was detected in surface water samples in Kazan at a concentration of 1×10−9 M.The purpose of this study is to study the presence of specific pharmacological effects of diclofenac detected in water samples in ultra-low doses in experimental models of pathological processes.Methods. The experiment used 21 male white laboratory mice, which were divided into three groups (each with 7 mice). For 4 days, mice were intragastrically injected with distilled water (control group), diclofenac solution 1×10−6 M (experimental group No. 1), diclofenac solution 1×10−9 M (experimental group No. 2). On the fifth day of the experiment, inflammation was induced by injecting carrageenan lambda (1 %, Sigma) subplantarly into the right hind paw in a volume of 0.05 ml. The amount of edema was determined using an IITC Life Science plethysmometer (USA).The results of an experimental study of the specific pharmacological activity of diclofenac showed that diclofenac in ultra-low doses of 0.32×10−3 mg per 100.0 g of weight is able to reduce the severity of acute inflammation caused by subplantar injection of carrageenan and to cause NSAID-associated gastropathy in mice.Conclusion. The obtained data likely indicate a potential risk of adverse effects from drug contamination of the environment with diclofenac, even in ultra-low concentrations.
Experimental model of autism spectrum disorder induced by prenatal administration of propionic acid to Wistar rats
Authors: Boyarkin V. S. , Kapitsa I. G. , Voronina T. A. 
Published: August 2024

Relevance. Autism spectrum disorder (ASD) is a developmental disorder of the brain with unclear etiology and pathophysiology, characterized by impaired social communication, stereotypic or repetitive behavior, and varying degrees of mental retardation. One of the environmental factors that have an adverse effect on pregnant women and embryo development is propionic acid (PPA), which is a secondary metabolite of the intestinal microbiota and is widely used as a food preservative. Under physiological conditions, PPC modulates cellular signal transduction, neurotransmitter synthesis and release, cellular interactions, gene expression, immune function, and affects mitochondrial and lipid metabolism. Excessive exposure to PPC can have a number of negative consequences on health and behavior, including leading to the development of ASD.The aim of present research was to assess behavioral characteristics in male and female Wistar rats with ASD caused by prenatal administration of sodium salt of propionic acid at the early perinatal and juvenile stages of development.Methods. In a model of ASD induced by prenatal administration of propionic acid at a dose of 500 mg/kg, subcutaneously on days 12–16 of gestation, behavior was assessed in the “nesting” and juvenile periods of life in male and female Wistar rats. Physical and neurological development, social behavior (“Maternal scent”, “Paired test”), repetitive behavior (Y-maze, “Auto-grooming”), motor and exploratory activity (“Mink test”) were assessed.Results. In Wistar rats prenatally treated with propionic acid, there was a slowdown in the formation of a number of reflexes at the stage of early postnatal development, and at a later stage – a decrease in social behavior, increased stereotypy and aggression, hyperlocomotion and low exploratory activity.Conclusion. The ASD model induced by prenatal administration of PPC is adequate and suitable for studying means of pharmacological correction of ASD.
Pharmacokinetics of a potential antiepileptic drug GIZh-298
Authors: Kolyvanov G. B. , Litvin A. A. , Kravtsova O. Yu. , Gribakina O. G. , Zherdev V. P. 
Published: August 2024

GIZh-298 pharmacokinetics was studied in rats after different dosage regimens.The aim of this study was to study GIZh-298 pharmacokinetics after its multiple intragastric administration.Methods. The study was conducted on outbred male rats. The concentrations of GIZh-298 in the blood plasma were determined by HPLC with mass-spectrometric detection. Pharmacokinetic parameters were evaluated using a model-independent method.Results. After single and multiple (4 times with a dosage interval of 3 hours) intragastric administrations at 60 mg/kg dose, the test substance in the blood plasma was determined for 4 hours. The mode of administration of GIZh-298 did not affect the value of its half-life and the mean residence time. It has been established that GIZh-298 accumulates in the rats.
Learning English through a Participatory and Collaborative Environment in Students from Rural Schools
Authors: Chavarría Mendoza Luis Alfredo , Macias Sera Raisa , Kaicer Pinargote Ángela María , Bazurto Alcívar Silvia Nancy , Intriago Cobeña María Cristina 
Published: August 2024

The present work covers the teaching and learning of English through the stimulation of a participatory and collaborative environment. Its main objective is the implementation of a strategy that enhances the learning of English as a Foreign Language (EFL) by creating the environment above mentioned. The paper explores the levels of participation and collaboration in English lessons by means of a diagnostic study that includes students from Eight Year of E.G.B to Third Year of B.G.U. and teachers of English. Effective techniques to develop such type of learning are also discussed. The results derived of the application of the strategy are debated as well.
Measuring the Conditional Luminosity and Stellar Mass Functions of Galaxies by Combining the Dark Energy Spectroscopic Instrument Legacy Imaging Surveys Data Release 9, Survey Validation 3, and Year 1 Data
Authors: Wang 王 Yirong 艺蓉 , Yang 杨 Xiaohu 小虎 , Gu 顾 Yizhou 一舟 , Xu 徐 Xiaoju 笑菊 , Xu 许 Haojie 浩杰 , Wang 王 Yuyu 钰钰 , Katsianis Antonios , Han 韩 Jiaxin 家信 , He 何 Min 敏 , Zheng 郑 Yunliang 云亮 , Li 李 Qingyang 清洋 , Wang 王 Yaru 雅茹 , Hong 洪 Wensheng 文生 , Wang 王 Jiaqi 佳琪 , Tan 谭 Zhenlin 镇林 , Zou 邹 Hu 虎 , Lange Johannes Ulf , Hahn ChangHoon , Behroozi Peter , Aguilar Jessica Nicole , Ahlen Steven , Brooks David , Claybaugh Todd , Cole Shaun , de la Macorra Axel , Dey Biprateep , Doel Peter , Forero-Romero Jaime E. , Honscheid Klaus , Kehoe Robert , Kisner Theodore , Lambert Andrew , Manera Marc , Meisner Aaron , Miquel Ramon , Moustakas John , Nie Jundan , Poppett Claire , Rezaie Mehdi , Rossi Graziano , Sanchez Eusebio , Schubnell Michael , Tarlé Gregory , Weaver Benjamin Alan , Zhou Zhimin 
Published: August 2024

Abstract
In this investigation, we leverage the combination of the Dark Energy Spectroscopic Instrument (DESI) Legacy Imaging Surveys Data Release 9, Survey Validation 3, and Year 1 data sets to estimate the conditional luminosity functions and conditional stellar mass functions (CLFs and CSMFs) of galaxies across various halo mass bins and redshift ranges. To support our analysis, we utilize a realistic DESI mock galaxy redshift survey (MGRS) generated from a high-resolution Jiutian simulation. An extended halo-based group finder is applied to both MGRS catalogs and DESI observation. By comparing the r- and z-band luminosity functions (LFs) and stellar mass functions (SMFs) derived using both photometric and spectroscopic data, we quantified the impact of photometric redshift (photo-z) errors on the galaxy LFs and SMFs, especially in the low-redshift bin at the low-luminosity/mass end. By conducting prior evaluations of the group finder using MGRS, we successfully obtain a set of CLF and CSMF measurements from observational data. We find that at low redshift, the faint-end slopes of CLFs and CSMFs below ∼109
h
−2
L
⊙ (or h
−2
M
⊙) evince a compelling concordance with the subhalo mass functions. After correcting the cosmic variance effect of our local Universe following Chen et al., the faint-end slopes of the LFs/SMFs turn out to also be in good agreement with the slope of the halo mass function.
On the Origin of Star Formation Quenching of Galaxies in Group Environments Using the NewHorizon Simulation
Authors: Rhee Jinsu , Yi Sukyoung K. , Ko Jongwan , Contini Emanuele , Jang J. K. , Jeon Seyoung , Han San , Pichon Christophe , Dubois Yohan , Kraljic Katarina , Peirani Sébastien 
Published: August 2024

Abstract
We study star formation (SF) quenching of satellite galaxies with M
* > 107
M
⊙ within two low-mass groups (M
vir = 1012.9 and 1012.7
M
⊙) using the NewHorizon simulation. We confirm that satellite galaxies (M
* ≲ 1010
M
⊙) are more prone to quenching than their field counterparts. This quenched fraction decreases with increasing stellar mass, consistent with recent studies. Similar to the findings in cluster environments, we note a correlation between the orbital motions of galaxies within these groups and the phenomenon of SF quenching. Specifically, SF is suppressed at the group center, and for galaxies with M
* > 109.1
M
⊙, there is often a notable rejuvenation phase following a temporary quenching period. The SF quenching at the group center is primarily driven by changes in SF efficiency and the amount of gas available, both of which are influenced by hydrodynamic interactions between the interstellar medium and surrounding hot gas within the group. Conversely, satellite galaxies with M
* < 108.2
M
⊙ experience significant gas removal within the group, leading to SF quenching. Our analysis highlights the complexity of SF quenching in satellite galaxies in group environments, which involves an intricate competition between the efficiency of SF (which depends on the dynamical state of the gas) on the one hand, and the availability of cold dense gas on the other hand. This challenges the typical understanding of environmental effects based on gas stripping through ram pressure, suggesting a need for a new description of galaxy evolution under mild environmental effects.
A NICER View of the Nearest and Brightest Millisecond Pulsar: PSR J0437–4715
Authors: Choudhury Devarshi , Salmi Tuomo , Vinciguerra Serena , Riley Thomas E. , Kini Yves , Watts Anna L. , Dorsman Bas , Bogdanov Slavko , Guillot Sebastien , Ray Paul S. , Reardon Daniel J. , Remillard Ronald A. , Bilous Anna V. , Huppenkothen Daniela , Lattimer James M. , Rutherford Nathan , Arzoumanian Zaven , Gendreau Keith C. , Morsink Sharon M. , Ho Wynn C. G. 
Published: August 2024

Abstract
We report Bayesian inference of the mass, radius, and hot X-ray emitting region properties—using data from the Neutron Star Interior Composition ExploreR (NICER)—for the brightest rotation-powered millisecond X-ray pulsar, PSR J0437−4715. Our modeling is conditional on informative tight priors on mass, distance, and binary inclination obtained from radio pulsar timing using the Parkes Pulsar Timing Array (PPTA; Reardon et al.), and we use NICER background models to constrain the nonsource background, cross-checking with data from XMM-Newton. We assume two distinct hot emitting regions and various parameterized hot region geometries that are defined in terms of overlapping circles; while simplified, these capture many of the possibilities suggested by detailed modeling of return current heating. For the preferred model identified by our analysis, we infer a mass of M = 1.418 ± 0.037 M
⊙ (largely informed by the PPTA mass prior) and an equatorial radius of

R
=

11.36

−
0.63

+
0.95

km, each reported as the posterior credible interval bounded by the 16% and 84% quantiles. This radius favors softer dense matter equations of state and is highly consistent with constraints derived from gravitational wave measurements of neutron star binary mergers. The hot regions are inferred to be nonantipodal and hence inconsistent with a pure centered dipole magnetic field.
The Neutron Star Mass, Distance, and Inclination from Precision Timing of the Brilliant Millisecond Pulsar J0437-4715
Authors: Reardon Daniel J. , Bailes Matthew , Shannon Ryan M. , Flynn Chris , Askew Jacob , Bhat N. D. Ramesh , Chen Zu-Cheng , Curyło Małgorzata , Feng Yi , Hobbs George B. , Kapur Agastya , Kerr Matthew , Liu Xiaojin , Manchester Richard N. , Mandow Rami , Mishra Saurav , Russell Christopher J. , Shamohammadi Mohsen , Zhang Lei , Zic Andrew 
Published: August 2024

Abstract
The observation of neutron stars enables the otherwise impossible study of fundamental physical processes. The timing of binary radio pulsars is particularly powerful, as it enables precise characterization of their (three-dimensional) positions and orbits. PSR J0437–4715 is an important millisecond pulsar for timing array experiments and is also a primary target for the Neutron Star Interior Composition Explorer (NICER). The main aim of the NICER mission is to constrain the neutron star equation of state by inferring the compactness (M

p
/R) of the star. Direct measurements of the mass M

p
from pulsar timing therefore substantially improve constraints on the radius R and the equation of state. Here we use observations spanning 26 yr from Murriyang, the 64 m Parkes radio telescope, to improve the timing model for this pulsar. Among the new precise measurements are the pulsar mass M

p
= 1.418 ± 0.044 M
⊙, distance D = 156.96 ± 0.11 pc, and orbital inclination angle i = 137.°506 ± 0.°016, which can be used to inform the X-ray pulse profile models inferred from NICER observations. We demonstrate that these results are consistent between multiple data sets from the Parkes Pulsar Timing Array (PPTA), each modeled with different noise assumptions. Using the longest available PPTA data set, we measure an apparent second derivative of the pulsar spin frequency and discuss how this can be explained either by kinematic effects due to the proper motion and radial velocity of the pulsar or excess low-frequency noise such as a gravitational-wave background.
The Unluckiest Star: A Spectroscopically Confirmed Repeated Partial Tidal Disruption Event AT 2022dbl
Authors: Lin Zheyu , Jiang Ning , Wang Tinggui , Kong Xu , Li Dongyue , He Han , Wang Yibo , Zhu Jiazheng , Li Wentao , Jiang Ji-an , Singh Avinash , Teja Rishabh Singh , Sahu D. K. , Jin Chichuan , Maeda Keiichi , Huang Shifeng 
Published: August 2024

Abstract
The unluckiest star orbits a supermassive black hole elliptically. Every time it reaches the pericenter, it shallowly enters the tidal radius and gets partially tidally disrupted, producing a series of flares. Confirmation of a repeated partial tidal disruption event (pTDE) requires not only evidence to rule out other types of transients but also proof that only one star is involved, as TDEs from multiple stars can also produce similar flares. In this Letter, we report the discovery of a repeated pTDE, AT 2022dbl. In a quiescent galaxy at z = 0.0284, two separate optical/UV flares have been observed in 2022 and 2024 with no bright X-ray, radio, or mid-infrared counterparts. Compared to the first flare, the second flare has a similar blackbody temperature of ∼26,000 K, slightly lower peak luminosity, and slower rise and fall phases. Compared to the Zwicky Transient Facility TDEs, their blackbody parameters and light-curve shapes are all similar. The spectra taken during the second flare show a steeper continuum than the late-time spectra of the previous flare, consistent with a newly risen flare. More importantly, the possibility of two independent TDEs can be largely ruled out because the optical spectra taken around the peak of the two flares exhibit highly similar broad Balmer, N iii, and possible He ii emission lines, especially the extreme ∼4100 Å emission lines. This represents the first robust spectroscopic evidence for a repeated pTDE, which can soon be verified by observing the third flare, given its short orbital period.
Safety and Effectiveness of Laser in Situ Keratomileusis Using the Teneo 317 Model 2 for Correcting Myopia and Myopic Astigmatism: Results of the U.S. FDA Clinical Trial
Authors: Waring George O. , Stonecipher Karl , Lobanoff Mark , Chu Y. Ralph , Endl Michael , Feinerman Gregg , Hosten Lester O. , Kumar Nisha 
Published: August 2024

Purpose:
To evaluate the safety and effectiveness of a new aspheric ablation profile for correcting myopia and myopic astigmatism.

Methods:
This prospective, multicenter study included patients who underwent laser in situ keratomileusis (LASIK) using a new aspheric ablation profile of the Technolas Teneo 317 (Model 2) excimer laser (version 1.28 US SW) by Technolas Perfect Vision, Bausch+Lomb, Inc. No nomogram adjustments were made, and the patient's manifest refraction was entered into the laser (for treatment). Postoperative assessments included visual and refractive outcomes. Patients were asked to complete the Patient-Reported Outcomes With LASIK (PROWL) questionnaire preoperatively and postoperatively.

Results:
A total of 333 eyes from 168 patients with a mean age of 33 ± 7 years were included. At postoperative 9 months, uncorrected and corrected distance visual acuities of 20/25 or better were seen in 97.8% and 100% of eyes, respectively. None of the eyes lost two or more lines of corrected distance visual acuity. The mean manifest spherical refraction improved from −5.67 ± 2.52 diopters (D) preoperatively to −0.04 ± 0.32 D postoperatively, with 92.7% of eyes achieving residual refractive error within ±0.50 D. Residual refractive cylinder within ±0.50 and ±1.00 D was seen in 93% and 99.4% eyes, respectively. The refractive outcomes were stable throughout the follow-up of 9 months. The proportion of patients satisfied with their vision rose from 27.7% preoperatively to 98.1% postoperatively.

Conclusions:
LASIK performed using a new aspheric ablation profile of the Technolas Teneo 317 (Model 2) excimer laser is safe and effective for correcting myopia and myopic astigmatism, yielding excellent visual and refractive outcomes that were stable over 9 months.

[
J Refract Surg
. 2024;40(8):e544–e553.]
Predictability of varicocele repair success: preliminary results of a machine learning-based approach
Authors: Crafa Andrea , Russo Marco , Cannarella Rossella , Gül Murat , Compagnone Michele , Mongioì Laura M , Cannarella Vittorio , Condorelli Rosita A , Vignera Sandro La , Calogero Aldo E 
Published: August 2024

Abstract
Varicocele is a prevalent condition in the infertile male population. However, to date, which patients may benefit most from varicocele repair is still a matter of debate. The purpose of this study was to evaluate whether certain preintervention sperm parameters are predictive of successful varicocele repair, defined as an improvement in total motile sperm count (TMSC). We performed a retrospective study on 111 patients with varicocele who had undergone varicocele repair, collected from the Department of Endocrinology, Metabolic Diseases and Nutrition, University of Catania (Catania, Italy), and the Unit of Urology at the Selcuk University School of Medicine (Konya, Türkiye). The predictive analysis was conducted through the use of the Brain Project, an innovative tool that allows a complete and totally unbiased search of mathematical expressions that relate the object of study to the various parameters available. Varicocele repair was considered successful when TMSC increased by at least 50% of the preintervention value. For patients with preintervention TMSC below 5 × 106, improvement was considered clinically relevant when the increase exceeded 50% and the absolute TMSC value was >5 × 106. From the preintervention TMSC alone, we found a model that predicts patients who appear to benefit little from varicocele repair with a sensitivity of 50.0% and a specificity of 81.8%. Varicocele grade and serum follicle-stimulating hormone (FSH) levels did not play a predictive role, but it should be noted that all patients enrolled in this study were selected with intermediate- or high-grade varicocele and normal FSH levels. In conclusion, preintervention TMSC is predictive of the success of varicocele repair in terms of TMSC improvement in patients with intermediate- or high-grade varicoceles and normal FSH levels.
The role of endogenous testosterone in relationship with low- and intermediate-risk prostate cancer: a systematic review
Authors: Porcaro Antonio Benito , Serafin Emanuele , Brusa Davide , Costantino Sonia , Brancelli Claudio , Cerruto Maria Angela , Antonelli Alessandro 
Published: August 2024

Abstract
An enduring debate in research revolves around the association between elevated endogenous testosterone levels and prostate cancer. This systematic review is intended to assess the present understanding of the role of endogenous testosterone in the diagnosis and treatment of low- and intermediate-risk prostate cancer. Our search strategy was the following: (endogenous testosterone) AND (((low risk) OR (intermediate risk)) AND ((diagnosis) OR (treatment))) AND (prostate cancer); that was applied to PubMed, Web of Science, and Scopus databases to identify pertinent articles. Two investigators performed an independent selection following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The preliminary investigation detected 105 records, and 81 records remained after eliminating duplicates. Following the review of titles and abstracts, 71 articles were excluded. A comprehensive examination of the full text was conducted for 10 articles, excluding 3 of them. After revising the references of eligible articles, other 3 articles were included. We finally identified 10 suitable studies, including three main topics: (1) association between endogenous testosterone and European Association of Urology (EAU) risk classes; (2) association between endogenous testosterone density and the tumor load; and (3) association of endogenous testosterone with tumor upgrading and tumor upstaging. Actual literature about the impact of endogenous testosterone on low- and intermediate-risk prostate cancer is not numerous, but appears to be still conflicting. More investigations are needed to increase the consistency of the literature’s results.