bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relation between cancer patient treatment decision‐making roles and quality of life
Authors: Atherton Pamela J. , Smith Tenbroeck , Singh Jasvinder A. , Huntington Jef , Diekmann Brent B. , Huschka Mashele , Sloan Jeff A. 
Published: April 2013

BACKGROUNDThe objective of this study was to explore relations between patient role preferences during the cancer treatment decision‐making process and quality of life (QOL).METHODSOne‐year cancer survivors completed a survey in 2000 as part of a larger survey conducted by the American Cancer Society. The current report was based on survey respondents from Minnesota (response rate, 37.4%). Standardized measures included the Profile of Mood States (scores were converted to have a range, from 0 to 100, with 100 indicating the best mood), the Medical Outcomes Survey 36‐item short‐form health survey (SF‐36) (standardized scores), and the Control Preferences Scale. Patients' actual and preferred role preference distributions and concordance between roles were compared with QOL scores using 2‐sample t test methodology.RESULTSThe actual role of survivors (n = 594) in cancer care was 33% active, 50% collaborative, and 17% passive. Their preferred role was 35% active, 53% collaborative, and 13% passive. Overall, 88% of survivors had concordant preferred and actual roles. Survivors who had concordant roles had higher SF‐36 Physical Component Scale (PCS) scores (P < .01), higher vitality (P = .01), less fatigue (P < .01), less confusion (P = .01), less anger (P = .046), and better overall mood (P = .01). These results were similar among both women and younger individuals (aged <60 years). Survivors who had active actual roles had higher PCS scores (P < .01), less tension (P = .04), and higher vitality (P = .04) than survivors who were either collaborative or passive. No differences existed in QOL scores according to preferred role.CONCLUSIONSSurvivors who experienced discordance between their actual role and their preferred role reported substantial QOL deficits in both physical and emotional domains. These results indicate the need to support patient preferences. Cancer 2013;119:2342–2349. © 2013 American Cancer Society.
Generate‐map‐reduce: An extension to map‐reduce to support shared data and recursive computations
Authors: Dharanipragada Janakiram , Iyer Geeta , Kailasam Sriram 
Published: April 2013

SUMMARYIt is difficult to express the parallelism present in complex computations by using existing higher level abstractions such as MapReduce and Dryad. These computations include applications from wide variety of domains, like Artificial Intelligence, Decision Tree Algorithms, Association Rule Mining, Recommender Systems, Graph Algorithms, Clustering Algorithms, Compute Intensive Scientific Workflows, Optimization Algorithms, and so forth. Their execution graphs introduce new challenges in terms of programmer expressibility and runtime performance such as iterative and recursive computations, shared communication model, and so forth. We propose an extension to MapReduce, called Generate‐Map‐Reduce (GMR), targeted towards modeling these applications. GMR introduces a new Generate abstraction into the MapReduce framework that captures recursive computations. The runtime also supports iterative jobs and a distributed communication model by using shared data structures. We illustrate recursive computations with GMR by modeling complex applications such as simulated annealing, A* search, and adaptive quadrature computation that require recursive spawning of new tasks to handle variable degree of parallelism. GMR runtime supports caching of common data across iterations in memory and local disks. We illustrate how this caching helps in achieving significant speedup for iterative computations by modeling k‐means clustering. Copyright © 2013 John Wiley & Sons, Ltd.
The impact of bitwise operators on hash uniformity in network packet processing
Authors: Xiong Bing , Yang Kun , Li Feng , Chen Xiaosu , Zhang Jianming , Tang Qiang , Luo Yuansheng 
Published: April 2013

SUMMARYHash functions are widely applied in network packet processing, and uniformity is one of their determinant attributes. This paper investigates into the impact of bitwise operators on the uniformity of such hash functions. To this end, we first define connection identifier as their input keyword, whose uniformity is quantized by deviation index. Then, we analyze the impact of all bitwise operators on the deviation indices of its operation results. As for binary bitwise operators, we give the conditions where AND, OR and XOR increase bit uniformity, respectively, and conclude that only XOR improves the uniformity of bits in the connection identifier effectively by verifying these conditions with real network traffic. Furthermore, we derive a positive linear relationship of the uniformity of a bit‐stream and that of its any bit under simple independence assumption. As for unary bitwise operators, we prove that NOT keeps bit‐stream uniformity as the same even combined with XOR. Nevertheless, we find that circular shift with XOR changes bit‐stream uniformity with a great probability. In particular, a way is proposed to determine the optimal staggered number of two bit‐streams before their XOR operation. Lastly, we provide guidelines to design uniform hash functions with circular shift and XOR. Copyright © 2013 John Wiley & Sons, Ltd.
On the Electronic Structure ofmer,trans‐[RuCl3(1H‐indazole)2(NO)], a Hypothetical Metabolite of the Antitumor Drug Candidate KP1019: An Experimental and DFT Study
Authors: Bučinský Lukas , Büchel Gabriel E. , Ponec Robert , Rapta Peter , Breza Martin , Kožíšek Jozef , Gall Marian , Biskupič Stanislav , Fronc Marek , Schiessl Katharina , Cuzan Olesea , Prodius Denis , Turta Constantin , Shova Sergiu , Zając Dariusz A. , Arion Vladimir B. 
Published: April 2013

AbstractThe study reported herein focused on the electronic structure of the {Ru(NO)}6fragment and characterization of the oxidation state of ruthenium inmer,trans‐[RuCl3(Hind)2(NO)] (1; Hind = 1H‐indazole) resulting from the reaction ofmer,trans‐[RuCl3(H2O)(Hind)2] (2) with NO in acetone or solid‐state Anderson rearrangement of (H2ind)2[RuCl5(NO)] at 180 °C. The results of X‐ray diffraction,1H,13C, and15N NMR, EPR, IR, and UV/Vis spectroscopy, cyclic voltammetry, magnetic susceptibility, and XANES/EXAFS as well as theoretical data have been critically analyzed. The localized orbitals, domain‐averaged Fermi holes, frontier orbitals, Mulliken population, and quantum theory of atoms‐in‐molecules (QTAIM) analyses are presented. In addition,mer,trans‐[RuIIICl3(H2O)(Hind)2] (2) andtrans‐[RuIICl2(Hind)4] (3) were experimentally and theoretically investigated as reference compounds. A complete active space SCF calculation was performed to estimate the extent of antiferromagnetic spin–spin coupling in1. We found that the closed‐shell structure {RuIII(NO)0}6fits better to the physical/spectroscopic properties of1, although {RuII(NO)+}6is formally still suitable for describing the oxidation state of Ru in this entity.
(β‐D‐Ribofuranosyl)formamidine in the Design and Synthesis of 2‐(β‐D‐Ribofuranosyl)pyrimidines, Including RF‐Containing Derivatives
Authors: Iaroshenko Viktor O. , Dudkin Sergii , Sosnovskikh Vyacheslav Ya. , Villinger Alexander , Langer Peter 
Published: April 2013

AbstractA wide range of novel 2‐(β‐D‐ribofuranosyl)pyrimidines, including RF‐containing derivatives, have been synthesized by the reaction of (β‐D‐ribofuranosyl)formamidine with various dielectrophilic substrates such as 3‐alkoxy‐ and 3‐chloro‐1‐(polyfluoroalkyl)propen‐1‐ones, 3‐nitro‐ and 3‐(phenylethynyl)chromones and heteroaryl acetylenic ketones.
Reduced sampling and incomplete sensitivity for low‐complexity robust parametric optimization
Authors: Mohammadi Bijan 
Published: April 2013

SUMMARYThe paper considers robust parametric optimization problems using multipoint formulations and makes the link with momentum‐based formulations. Optimal sampling issues are discussed, and a procedure is proposed to quantify the confidence level on the robustness of the design. We also discuss incomplete sensitivity evaluations to take into account the computational complexity constraint. This permits to take advantage of what was previously developed for efficient monopoint design where the cost of the optimization is comparable with one state evaluations. The proposed algorithm is fully parallel and the time‐to‐solution is comparable with monopoint situations. Concepts are introduced through simple examples, and the paper ends with the design of the shape of an aircraft robust over a range of transverse winds.Copyright © 2013 John Wiley & Sons, Ltd.
Toll‐like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon‐β
Authors: Costello Derek A. , Lynch Marina A. 
Published: April 2013

ABSTRACTThe family of toll‐like receptors (TLR) plays a major role in innate immunity due to their pathogen‐recognition abilities. TLR3 is a sensor for double‐stranded RNA, and regulates host‐defense responses to several viruses, via the production of type I interferons. Interferon‐β (IFNβ) is a primary product of TLR3 activation, and its transcription is elevated in the CNS response to the synthetic TLR3 ligand, polyinosinic‐polycytidylic acid (poly(I:C)). Peripheral infections, along with TLR‐induced inflammatory mediators, are known to have detrimental effects on brain function, exerting a negative impact on cognition and enhancing seizure susceptibility. In this study, we assessed hippocampal function in vitro, in response to systemic delivery of a TLR3 agonist. Unlike agonists of other TLRs, intraperitoneal injection of poly(I:C) did not adversely affect evoked short‐ and long‐term synaptic plasticity in mouse hippocampal slices. However, sustained and interictal‐like spontaneous activity was observed in CA1 pyramidal cells in response to poly(I:C) and this was associated with alterations in the expression of phosphorylated NR2B subunit‐containing NMDA receptors and an astrocyte‐specific glutamate/aspartate transporter (GLAST) which impact on extracellular glutamate concentration and contribute to the genesis of epileptiform activity. We provide evidence for the production of IFNβ from microglia and astrocytes, and using mice deficient in the type I IFN receptor α 1 (IFNAR1), demonstrate that its subsequent activation is likely to underlie the TLR3‐mediated modulation of hippocampal excitability. © 2013 Wiley Periodicals, Inc.
In vivo contribution of nestin‐ and GLAST‐lineage cells to adult hippocampal neurogenesis
Authors: DeCarolis Nathan A. , Mechanic Maxwell , Petrik David , Carlton Adam , Ables Jessica L. , Malhotra Shveta , Bachoo Robert , Götz Magdalena , Lagace Diane C. , Eisch Amelia J. 
Published: April 2013

ABSTRACTRadial glia‐like cells (RGCs) are the hypothesized source of adult hippocampal neurogenesis. However, the current model of hippocampal neurogenesis does not fully incorporate the in vivo heterogeneity of RGCs. In order to better understand the contribution of different RGC subtypes to adult hippocampal neurogenesis, we employed widely used transgenic lines (Nestin‐CreERT2 and GLAST::CreERT2 mice) to explore how RGCs contribute to neurogenesis under basal conditions and after stimulation and depletion of neural progenitor cells. We first used these inducible fate‐tracking transgenic lines to define the similarities and differences in the contribution of nestin‐ and GLAST‐lineage cells to basal long‐term hippocampal neurogenesis. We then explored the ability of nestin‐ and GLAST‐lineage RGCs to contribute to neurogenesis after experimental manipulations that either ablate neurogenesis (i.c.v. application of the anti‐mitotic AraC, cytosine‐β‐D‐arabinofuranoside) or stimulate neurogenesis (wheel running). Interestingly, in both ablation and stimulation experiments, labeled RGCs in GLAST::CreERT2 mice appear to contribute to neurogenesis, whereas RGCs in Nestin‐CreERT2 mice do not. Finally, using NestinGFP reporter mice, we expanded on previous research by showing that not all RGCs in the adult dentate gyrus subgranular zone express nestin, and therefore RGCs are antigenically heterogeneous. These findings are important for the field, as they allow appropriately conservative interpretation of existing and future data that emerge from these inducible transgenic lines. These findings also raise important questions about the differences between transgenic driver lines, the heterogeneity of RGCs, and the potential differences in progenitor cell behavior between transgenic lines. As these findings highlight the possible differences in the contribution of cells to long‐term neurogenesis in vivo, they indicate that the current models of hippocampal neurogenesis should be modified to include RGC lineage heterogeneity. © 2013 Wiley Periodicals, Inc.
Comparative stability of the bioresorbable ferric crosslinked hyaluronic acid adhesion prevention solutions
Authors: Luu Hoan‐My Do , Chen Angela , Isayeva Irada S. 
Published: April 2013

AbstractThe Intergel® ferric crosslinked hyaluronate (FeHA) adhesion prevention solution (APS) (FDA) is associated with serious post‐operative complications (Henley, http://www.lawyersandsettlements.com/features/gynecare‐intergel/intergel‐timeline.html, 2007; FDA, 2003; Roman et al., Fertil Steril 2005, 83 Suppl 1:1113–1118; Tang et al., Ann Surg 2006;243(4):449–455; Wiseman, Fertil Steril 2006;86(3):771; Wiseman, Fertil Steril 2006;85(4):e7). This prompted us to examine the in situ stability of crosslinked HA materials to hyaluronidase lyase degradation. Variables such as ferric ionic crosslink density, HA concentration, gel geometry, and molecular weight (MW) of HA polymer were studied. Various formulations of the crosslinked “in house” [Isayeva et al., J Biomed Mater Res: Part B – Appl Biomater 2010, 95B (1):9–18] FeHA (0.5%, w/v; 30, 50, 90% crosslinked), the Intergel® FeHA (0.5%, w/v; 90%), and the non‐crosslinked HA (0.05–0.5%, w/v) were degraded at a fixed activity of hyaluronidase lyase from Streptomyces hyalurolyticus (Hyase) at 37°C over time according to the method [Payan et al., J Chrom B: Biomed Sci Appl 1991;566(1):9–18]. Under our conditions, the data show that the crosslink density affects degradation the most, followed by HA concentration and then gel geometry. We found that MW has no effect. Our results are one possible explanation of the observations that the Intergel® FeHA APS (0.5%, w/v; 90%) material persisted an order of magnitude longer than expected [t1/2 = 500 hrs vs. t1/2 = 50 hrs (FDA; Johns et al., Fertil Steril 1997;68(1):37–42)]. These data also demonstrate the sensitivity of the in vitro hyaluronidase assay to predict the in situ stability of crosslinked HA medical products as previously reported [Sall et al., Polym Degrad Stabil 2007;92(5):915–919]. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.
Formability and mechanical properties of porous titanium produced by a moldless process
Authors: Naito Yoshihito , Bae Jiyoung , Tomotake Yoritoki , Hamada Kenichi , Asaoka Kenzo , Ichikawa Tetsuo 
Published: April 2013

AbstractTailor‐made porous titanium implants show great promise in both orthopedic and dental applications. However, traditional powder metallurgical processes require a high‐cost mold, making them economically unviable for producing unique devices. In this study, a mixture of titanium powder and an inlay wax binder was developed for moldless forming and sintering. The formability of the mixture, the dimensional changes after sintering, and the physical and mechanical properties of the sintered porous titanium were evaluated. A 90:10 wt % mixture of Ti powder and wax binder was created manually at 70°C. After debindering, the specimen was sintered in Ar at 1100°C without any mold for 1, 5, and 10 h. The shrinkage, porosity, absorption ratio, bending and compressive strength, and elastic modulus were measured. The bending strength (135–356 MPa), compression strength (178–1226 MPa), and elastic modulus (24–54 GPa) increased with sintering time; the shrinkage also increased, whereas the porosity (from 37.1 to 29.7%) and absorption ratio decreased. The high formability of the binder/metal powder mixture presents a clear advantage for fabricating tailor‐made bone and hard tissue substitution units. Moreover, the sintered compacts showed high strength and an elastic modulus comparable to that of cortical bone. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.
Promotion of mouse ameloblast proliferation by Lgr5 mediated integrin signaling
Authors: Yoshida Toshiyuki , Iwata Takanori , Umemoto Terumasa , Shiratsuchi Yoshiko , Kawashima Nobuyuki , Sugiyama Toshihiro , Yamato Masayuki , Okano Teruo 
Published: April 2013

ABSTRACTRodent incisors grow throughout the animal's lives, and the tooth‐forming cells are provided from proximal ends of the incisors where the tooth epithelium forms a stem cell niche called cervical loop. The committing cells in a cervical loop actively begin to proliferate (pre‐ameloblasts), and differentiating into ameloblasts. This study showed that the lower incisors of mice null for CD61 (CD61−/−), also known as integrin β3, were significantly shorter than those of the wild‐type mice at 8‐week‐old. The protein and mRNA expressions levels of Fgfr2, Lgr5, and Notch1, which are known to be involved in pre‐ameloblastic cell proliferation and stem cell maintenance, were reduced in the cervical loop of 2‐week‐old CD61−/− mice. The proliferation of pre‐ameloblasts was reduced in CD61−/− ameloblasts. The siRNA‐mediated suppression of CD61 (siCD61) reduced the proliferation of pre‐ameloblastic cell line ALC, and the expression levels of Lgr5 and Notch1 were reduced by the transfection with siCD61. The suppression of Lgr5 by transfection with siLgr5 suppressed the proliferation of the ALC cells. These results suggested that CD61 signaling is required for the proper growth of the cervical loop and for the promotion of the proliferation of pre‐ameloblastic cells through Lgr5. J. Cell. Biochem. 114: 2138–2147, 2013. © 2013 Wiley Periodicals, Inc.
MiR‐23a in amplified 19p13.13 loci targets metallothionein 2A and promotes growth in gastric cancer cells
Authors: An Juan , Pan Yuanming , Yan Zhi , Li Wenmei , Cui Jiantao , Yuan Jiao , Tian Liqing , Xing Rui , Lu Youyong 
Published: April 2013

ABSTRACTCopy number variation (CNV) and abnormal expression of microRNAs (miRNAs) always lead to deregulation of genes in cancer, including gastric cancer (GC). However, little is known about how CNVs affect the expression of miRNAs. By integrating CNV and miRNA profiles in the same samples, we identified eight miRNAs (miR‐1274a, miR‐196b, miR‐4298, miR‐181c, miR‐181d, miR‐23a, miR‐27a and miR‐24‐2) that were located in the amplified regions and were upregulated in GC. In particular, amplification of miR‐23a‐27a‐24‐2 cluster and miR‐181c‐181d cluster frequently occurred at 19p13.13 and were confirmed by genomic real‐time PCR in another 25 paired GC samples. Moreover, in situ hybridization (ISH) experiments represented that mature miR‐23a was increased in GCs (75.5%, 40/53) compared with matched normal tissues (28.6%, 14/49, P = 0.001). Knocking down of miR‐23a expression inhibited BGC823 cell growth in vitro and in vivo. In addition, the potential target genes of miR‐23a were investigated by integration of mRNA profile and miRNA TargetScan predictions, we found that upregulation of miR‐23a and downregulation of metallothionein 2A (MT2A) were detected simultaneously in 70% (7/10) of the miRNA and mRNA profiles. Furthermore, an inverse correlation between miR‐23a and MT2A expression was detected in GCs and normal tissues. Through combining luciferase assay, we confirmed that MT2A is a potential target of miR‐23a. In conclusion, these results suggest that integration of CNV‐miRNA‐mRNA profiling is a powerful tool for identifying molecular signatures, and that miR‐23a might play a role in regulating MT2A expression in GC. J. Cell. Biochem. 114: 2160–2169, 2013. © 2013 Wiley Periodicals, Inc.
Foamy virus‐adenovirus hybrid vectors for gene therapy of the arthritides
Authors: Weber Conrad , Armbruster Nicole , Scheller Carsten , Kreppel Florian , Kochanek Stefan , Rethwilm Axel , Steinert Andre F. 
Published: March 2013

AbstractBackgroundGenetic treatments of chronic arthritic conditions are essentially dependent on safe and efficient vector systems. To combine features of the efficient transduction of adenovirus vectors with the advantage of stable integration into the host cell genome of apathogenic prototype foamy virus vectors, hybrid vectors (FAD) have been established. In the present study, we have generated and investigated the use of safe FAD vectors for direct gene delivery to joints.MethodsWe generated recombinant FAD encoding enhanced green fluorescent protein (EGFP) or human interleukin 1 receptor antagonist protein (IL1RA) cDNA, and explored their transgene expression profile, as well as the bioactivity of the IL1RA transgene in vitro. The feasibility of IL1RA gene delivery to articular tissues was investigated in a pilot study employing direct FAD injections to the knee joints of Wistar rats.ResultsFAD vectors efficiently transduced human or rat fibroblasts with EGFP or IL1RA transgene in vitro. Levels of IL1RA transgene expression were high, stable and functional in vitro. Transduced synovial fibroblasts and high levels of IL1RA protein (10–35 ng/ml) could be detected in vivo in the synovium of Wistar rats 3–5 days after injection of FAD vectors to the knee joints.ConclusionsOur results indicate that FAD vectors are capable of efficient in vivo gene transfer to synovium and merit further investigation as a means of providing efficient and long‐term intra‐articular transgene expression for treatment of the arthritides. Copyright © 2013 John Wiley & Sons, Ltd.
Wind and submerged aquatic vegetation influence bio‐optical properties in large shallow Lake Taihu, China
Authors: Liu Xiaohan , Zhang Yunlin , Yin Yan , Wang Mingzhu , Qin Boqiang 
Published: April 2013

AbstractWe studied the bio‐optical properties and sediment dynamics of typical phytoplankton‐dominated (PD) and macrophyte‐dominated (MD) regions in shallow Lake Taihu in China, from long‐term site‐specific studies and short‐term high‐frequency observations. The long‐term studies showed that five parameters were significantly lower in the MD region than in the PD region: photosynthetically active radiation (PAR) diffuse attenuation coefficient (Kd(PAR)), concentrations of total suspended matter (CTSM), tripton (CTripton), and phytoplankton pigment (CChla+Pa), and CDOM absorption coefficient (aCDOM(350)). In winter in the MD region, with only scarce submerged aquatic vegetation (SAV) coverage, the Kd(PAR), CTSM, and CTripton were significantly higher than in the PD region with no SAV; in contrast, CChla+Pa and aCDOM(350) were significantly lower in the MD region than in the PD region. In the other three seasons with high SAV coverage, Kd(PAR), CTSM, CTripton, CChla+Pa, and aCDOM(350) were all significantly lower in the MD region than in the PD region. The appearance and growth of SAV decreased CTSM, CTripton, and Kd(PAR). The short‐term high‐frequency study showed that phytoplankton and tripton absorption coefficients were significantly lower in the MD region than in the PD region. In the PD region, there were highly significant exponential relationships between wind speed, wave height, and wave shear stress, and CTripton and Kd(PAR), showing that wind‐driven sediment resuspension could significantly affect both the tripton concentration and PAR attenuation. However, in the MD region, there were only weakly significant correlations, or no significant correlations, between wind speed, wave height, and wave shear stress, and CTripton, and Kd(PAR). The combination of the long‐term site‐specific and short‐term high‐frequency observations is an excellent tool for study of the bio‐optical properties in lake environments.