bluuebunny/crossref_metadata_2025_split huggingface dataset:
KOORDINASI PEMERINTAHAN DALAM MEWUJUDKAN TERTIB ADMINISTRASI PENDUDUK RENTAN DI KOTA PALU PROVINSI SULAWESI TENGAH
Authors: B Asri , Fatahilah Adee 
Published: August 2024

ABSTRACT
It is important to making systematic, coordinated and integrated for create collection data of population and handling between agencies in Palu city, to obtain valid data about the number of street children, vagrants, beggars, livelihoods and decent living because the number of them is always increased, so it must be handled in effective and efficient way. The purpose of research is to understand the basic tasks and functions of the of Population and Civil Registration Office, and knowing the orderly administration of vulnerable residents, and also to know the outcome process of realizing the orderly administration of vulnerable populations.
The conclusion of this study is coordination of Organization of Regional Devices in the data collection of vulnerable population in Palu City is adjusting the main tasks and functions of each agency, and the each instances still have sectoral ego so it make obstacles in coordination conducted on vulnerable population, and facilities and infrastructure owned by the government of Palu City in dealing with vulnerable residents are still inadequate.
The organization of the regional apparatus in the data collection on street children, homeless and beggars has made an effort to resolve the problem by conducting coordination meetings to do the main job list division in accordance of each agency function.
Keywords: orderly administration, streed children, homeless people, beggars

ABSTRAK
Pentingnya melakukan pandataan sistematik, terkoordinasi dan terintegrasi dalam pendataan kependudukan dan penanganan antara instansi di Kota Palu agar mendapatkan data jumlah anak jalanan, gelandangan dan pengemis yang valid serta bantuan penghidupan dan kehidupan yang layak karena jumlahnya yang semakin banyak sehingga harus di tangani dengan cara yang efektif dan efisien. Tujuan penelitian ini adalah untuk memahami tugas pokok dan fungsi Dinas Kependudukan dan Pencatatan Sipil, mengetahui tertib administrasi penduduk rentan, serta untuk mengetahui Hasil Kerja dari proses mewujudkan tertib administrasi Penduduk rentan.
Kesimpulan yang di dapatkan adalah koordinasi Organisasi Perangkat Daerah dalam pendataan penduduk rentan di Kota Palu dilakukan dengan menyesuaikan terhadap tugas pokok dan fungsi masing-masing tiap instansi, dan masih adanya ego sektoral antar instansi sehingga menimbulkan hambatan dalam koordinasi yang dilakukan terhadap penduduk rentan dan masih kurangnya sarana dan prasarana yang dimiliki oleh pemerintah Kota Palu dalam menangani para penduduk rentan.
Organisasi Perangkat Daerah dalam pendataan kependudukan terhadap anak jalanan, gelandangan dan pengemis telah melakukan upaya mengatasi masalah yang menjadi hambatan dengan melakukan rapat koordinasi kembali untuk dilakukan pembagian tugas yang sesuai dengan fungsi masing-masing instansi tersebut.
Kata kunci: tertib administrasi, anak jalanan, gelandangan dan pengemis
ANALISA KEBIJAKAN PELAYANAN ADMINISTRASI KEPENDUDUKAN DAN CATATAN SIPIL DIERA COVID19 DIKOTA BANDUNG
Authors: Elsye Rosmery 
Published: August 2024

Penerapan PSBB di Kota Bandung, sangat berdampak kepada layanan publik di Kota Bandung, hal ini dikarenakan aktiϐitas masyarakat dibatasi, dengan anjuran dari pemerintah untuk tetap tinggal dirumah, belajar dari rumah, bekerja dari rumah, dan ibadah tetap dirumah. Terkait dengan pelayanan publik, hampir semua kantor –kantor pelayanan publik pada lingkup pemerintahan ditutup untuk sementara waktu, yang dijinkan hanya terkait permasalahan Administrasi Kependudukan dan Catatan Sipil, yang dikelola oleh Dinas Dukcapil, dengan jam operasional dibatasi, dan tetap menjaga protokol kesehatan dengan menjaga jarak dan menggunakan masker, kunjungan dibatasi jumlahnya, tidak seperti biasanya, masyarakat dianjurkan apabila membutuhkan pelayanan untuk menggunakan aplikasi secara online kepada dinas-dinas pelayanan di Kota Bandung. Untuk itu peneliti tertarik untuk melakukan penelitian yang akan peneliti jadikan tulisan ilmiah dengan judul Analisa Kebijakan Pelayanan Administrasi Kependudukan dan Catatan sipil diera Covid 19 di Kota Bandung. Penelitian ini menggunakan metode kualitatif deskritif dengan pendekatan induktif, dan hasil yang didapat dalam penelitian ini adalah Dinas Dukcapil Kota Bandung diera pandemic covid 19, masih tetap menjalani pelayanan baik secara online maupun secara manual seperti biasanya, serta meningkatkan pelayanan dengan membuka unit-unit kantor pelayanan dan mobil pelayanan secara keliling mengunjungi warga masyarakat yang membutuhkan pelayanan administrasi kependudukan dan catatan sipil secara gratis, hasilnya masyarakat merasakan kepuasan dan dilayani dengan sangat baik.Kata kunci : Analisa, Kebijakan Pelayanan,Adminduk Capil
Meiotic deviations and endoreplication lead to diploid oocytes in female hybrids between bighead catfish (Clarias macrocephalus) and North African catfish (Clarias gariepinus)
Authors: Dedukh Dmitrij , Lisachov Artem , Panthum Thitipong , Singchat Worapong , Matsuda Yoichi , Imai Yukiko , Janko Karel , Srikulnath Kornsorn 
Published: August 2024

IntroductionReproductive isolation and hybrid sterility are mechanisms that maintain the genetic integrity of species and prevent the introgression of heterospecific genes. However, crosses of closely related species can lead to complex evolution, such as the formation of all-female lineages that reproduce clonally. Bighead catfish (Clarias macrocephalus) and North African catfish (C. gariepinus) diverged 40 million years ago. They are cultivated and hybridized in Thailand for human consumption. Male hybrids are sterile due to genome-wide chromosome asynapsis during meiosis. Although female hybrids are sometimes fertile, their chromosome configuration during meiosis has not yet been studied.MethodsWe analyzed meiosis in the hybrid female catfish at pachytene (synaptonemal complexes) and diplotene (lampbrush chromosomes), using immunostaining to detect chromosome pairing and double-stranded break formation, and FISH with species-specific satellite DNAs to distinguish the parental chromosomes.ResultsMore than 95% of oocytes exhibited chromosome asynapsis in female hybrid catfish; however, they were able to progress to the diplotene stage and form mature eggs. The remaining oocytes underwent premeiotic endoreplication, followed by synapsis and crossing over between sister chromosomes, similar to known clonal lineages in fish and reptiles.DiscussionThe occurrence of clonal reproduction in female hybrid catfish suggests a unique model for studying gametogenic alterations caused by hybridization and their potential for asexual reproduction. Our results further support the view that clonal reproduction in certain hybrid animals relies on intrinsic mechanisms of sexually reproducing parental species, given their multiple independent origins with the same mechanism.
Investigating the regulatory effect of Shen Qi Bu Qi powder on the gastrointestinal flora and serum metabolites in calves
Authors: Yang Haochi , Ren Jianming , Ji Peng , Zhang Xiaosong , Mai Zhanhai , Li Chenchen , Zhao Nianshou , Ma Ting , Zhu Xiaopeng , Hua Yongli , Wei Yanming 
Published: August 2024

ObjectTo investigate the effects of Shen Qi Bu Qi Powder (SQBQP) on the average daily gain, blood indexes, gastrointestinal microflora, and serum metabolites of calves.MethodsA total of 105 calves were randomly assigned to three groups (n = 35 per group): the control group (C, fed with a basal diet for 21 days) and two treatment groups (SQBQP-L and SQBQP-H, fed with the basal diet supplemented with 15 and 30 g/kg of SQBQP), respectively for 21 days. The active components of SQBQP were identified using LC-MS/MS. Serum digestive enzymes and antioxidant indices were determined by ELISA kits and biochemical kits, respectively. Serum differential metabolites were analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS), while flora in rumen fluid and fecal were analyzed by 16S rDNA sequencing. Further correlation analysis of gastrointestinal flora and serum metabolites of SQBQP-H and C groups were performed with Spearman’s correlation.ResultsThe principal active components of SQBQP mainly includes polysaccharides, flavonoids, and organic acids. Compared to the control group (C), calves in the SQBQP-H (high dose) and SQBQP-L (low dose) groups showed a significant increase in serum amylase (AMS) levels (P&lt;0.001), while lipase content significantly decreased (P&lt;0.05). Additionally, the average daily gain, T-AOC, and cellulase content of calves in the SQBQP-H group significantly increased (P&lt;0.05). Proteobacteria and Succinivibrio in the rumen flora of the SQBQP-H group was significantly lower than that of the C group (P&lt;0.05). The relative abundance of Proteobacteria, Actinobacteria, Candidatus_Saccharibacteria, Deinococcus_Thermus, Cyanobacteria, and Succinivibrio in the SQBQP-H group was significantly increased (P&lt;0.05), while the relative abundance of Tenericutes and Oscillibacter was significantly decreased (P&lt;0.05). Serum metabolomics analysis revealed 20 differential metabolites, mainly enriched in amino acid biosynthesis, β-alanine metabolism, tyrosine, and tryptophan biosynthesis metabolic pathways (P&lt;0.05). Correlation analysis results showed that Butyrivibrio in rumen flora and Oscillibacter_valericigenes in intestinal flora were significantly positively correlated with average daily gain, serum biochemical indexes, and differential metabolite (-)-Epigallocatechin (R&gt;0.58, P&lt;0.05).ConclusionSQBQP can promote calves weight gain and enhance health by modulating gastrointestinal flora and metabolic processes in the body.
Causal association between antidiabetic drugs and erectile dysfunction: evidence from Mendelian randomization
Authors: Feng Lin , Jinhua Wu , Shulin Guo , Jiangping Xie , Zhongxiang Liao , Xiaohong Liao 
Published: August 2024

BackgroundAntidiabetic drugs are widely used in clinical practice as essential drugs for the treatment of diabetes. The effect of hypoglycemic drugs on erectile dysfunction has not been fully proven due to the presence of multiple confounding factors.MethodsTwo-sample Mendelian randomization (TSMR) was used to examine the causal effect of antidiabetic drugs (including metformin, insulin and gliclazide) on erectile dysfunction. We used five robust analytic methods, of which the inverse variance weighting (IVW) method was the primary method, and also assessed factors such as sensitivity, pleiotropy, and heterogeneity. Effect statistics for exposures and outcomes were downloaded from publicly available data sets, including open Genome-Wide Association Studies (GWAS) and the UK Biobank (UKB).ResultsIn some of the hypoglycemic drug use, there was a significant causal relationship between metformin use and erectile dysfunction [Beta: 4.9386; OR:1.396E+02 (95% CI:9.13-2135); p-value: 0.0004), suggesting that metformin increased the risk of erectile dysfunction development. Also, we saw that gliclazide use also increased the risk of erectile dysfunction [Beta: 11.7187; OR:0.0125 (95% CI:12.44-1.21E+09); P value: 0.0125). There was no significant causal relationship between insulin use and erectile dysfunction [Beta: 3.0730; OR:21.6071 (95% CI:0.24-1942.38); p-value: 0.1806).Leave-one-out, MR-Egger, and MR-PRESSO analyses produced consistent results.ConclusionThe use of metformin and gliclazide have the potential to increase the risk of erectile dysfunction. There is no causal relationship between the use of insulin and erectile dysfunction.
Polycystic ovary syndrome in obstructive sleep apnea-hypopnea syndrome: an updated meta-analysis
Authors: He Jie , Ruan Xia , Li Jia 
Published: August 2024

BackgroundObstructive sleep apnea-hypopnea syndrome (OSAHS) is correlated with metabolic deterioration in patients experiencing polycystic ovary syndrome (PCOS). Women diagnosed with PCOS exhibit a heightened prevalence of OSAHS. This meta-analysis aims to assess the morbidity of OSAHS in women affected by PCOS and to examine the differences in metabolism-related indicators between OSAHS-positive and OSAHS-negative in women with PCOS.MethodsA comprehensive literature analysis of OSAHS morbidity in women with PCOS was conducted, utilizing databases such as CNKI, EMBASE, PubMed, Web of Science, and Wanfang. A comparison was carried out between patients with OSAHS-positive and those with OSAHS-negative in terms of their clinical characteristics and metabolic differences. The search language included English and Chinese. The acquired data were analyzed by employing RevMan 5.2 and Stata 11.0. Continuous variables with the same units were combined and analyzed through weighted mean differences (WMDs) as effect sizes, while continuous variables with different units were combined and analyzed through standardized mean differences (SMDs) as effect sizes. A conjoint analysis was performed on the basis of I2 value, using either a fixed effect model (I2 ≤ 50%) or a random effect model (I2 &gt; 50%).ResultsA total of 21 articles met the inclusion criteria for this study. The findings indicated that 20.8% of women with PCOS were found to have comorbid OSAHS. The subjects were categorized into various subgroups for meta-analysis on the basis of race, age, disease severity, body mass index (BMI), and diagnostic criteria of PCOS. The results revealed high morbidity of OSAHS in all subgroups. In addition, most metabolic indicators and parameters of metabolic syndrome were notably worse in women suffering from both PCOS and OSAHS in comparison to their counterparts solely diagnosed with PCOS.ConclusionThe current literature indicates higher morbidity of OSAHS among women with PCOS, linking OSAHS with worse metabolic status and obesity in this population. Consequently, clinicians are advised to prioritize the detection and management of OSAHS in women with PCOS.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#myprospero PROSPERO, identifier (CRD42024528264).
Exploring the causal association between epigenetic clocks and menopause age: insights from a bidirectional Mendelian randomization study
Authors: Wang Ling , Xu Shuling , Chen Rumeng , Ding Yining , Liu Menghua , Hou Chunyan , Wu Zhu , Men Xiaoju , Bao Meihua , He Binsheng , Li Sen 
Published: August 2024

BackgroundEvidence suggests a connection between DNA methylation (DNAm) aging and reproductive aging. However, the causal relationship between DNAm and age at menopause remains uncertain.MethodsEmploying established DNAm epigenetic clocks, such as DNAm Hannum age acceleration (Hannum), Intrinsic epigenetic age acceleration (IEAA), DNAm-estimated granulocyte proportions (Gran), DNAm GrimAge acceleration (GrimAgeAccel), DNAm PhenoAge acceleration (PhenoAgeAccel), and DNAm-estimated plasminogen activator inhibitor-1 levels (DNAmPAIadjAge), a bidirectional Mendelian randomization (MR) study was carried out to explore the potential causality between DNAm and menopausal age. The primary analytical method used was the inverse variance weighted (IVW) estimation model, supplemented by various other estimation techniques.ResultsDNAm aging acceleration or deceleration, as indicated by Hannum, IEAA, Gran, GrimAgeAccel, PhenoAgeAccel, and DNAmPAIadjAge, did not exhibit a statistically significant causal effect on menopausal age according to forward MR analysis. However, there was a suggestive positive causal association between age at menopause and Gran (Beta = 0.0010; 95% confidence interval (CI): 0.0004, 0.0020) in reverse MR analysis.ConclusionThe observed increase in granulocyte DNAm levels in relation to menopausal age could potentially serve as a valuable indicator for evaluating the physiological status at the onset of menopause.
Effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular and cerebrovascular diseases: a meta-analysis of controlled clinical trials
Authors: Wang Fei , Li Chunyu , Cui Lili , Gu Shuo , Zhao Junyu , Wang Haipeng 
Published: August 2024

ObjectiveEvaluate the effects of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on cardiovascular and cerebrovascular diseases.MethodsArticles of SGLT2i on cardiovascular and cerebrovascular diseases were searched. Two authors independently screened the literature, extracted the data, assessed the quality of the study and performed statistical analyses using Review Manager 5.4.ResultsRandom-effect model was used to merge the OR values, and the pooled effect showed that SGLT2i had significant preventive effects on cardiovascular death (OR=0.76, 95%CI 0.64 to 0.89), myocardial infarction (OR=0.90, 95%CI 0.84 to 0.96), heart failure (OR=0.69, 95%CI 0.64 to 0.74) and all-cause mortality (OR=0.65, 95%CI 0.58 to 0.73). Empagliflozin, dapagliflozin and canagliflozin all reduced the incidence of heart failure (OR=0.72, 95%CI 0.64 to 0.82; OR=0.56, 95%CI 0.39 to 0.80; OR=0.62, 95%CI 0.53 to 0.73), but only dapagliflozin displayed a favorable effect on inhibiting stroke (OR=0.78, 95%CI 0.63 to 0.98). SGLT2i could prevent stroke (OR=0.86, 95%CI 0.75 to 0.99), heart failure (OR=0.63, 95%CI 0.56 to 0.70) and all-cause mortality (OR=0.64, 95%CI 0.57 to 0.72) compared to DPP-4i. Furthermore, SGLT2i could reduce the incidence of heart failure (OR=0.72, 95%CI 0.67 to 0.77) and cardiovascular death (OR=0.72, 95%CI 0.54 to 0.95) in patients with high-risk factors.ConclusionsSGLT2i affects cardiovascular death, myocardial infarction, heart failure and all-cause mortality. Only dapagliflozin displayed a favorable effect on inhibiting stroke. SGLT2i could prevent stroke, heart failure and all-cause mortality compared to DPP-4i. In addition, SGLT2i significantly reduced the development of heart failure and cardiovascular death in patients with high-risk factors.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42024532783.
Genetics causal analysis of oral microbiome on type 2 diabetes in East Asian populations: a bidirectional two-sample Mendelian randomized study
Authors: Lyu Xinyi , Xu Xueyuan , Shen Sihong , Qin Feng 
Published: August 2024

IntroductionThe dysbiosis of the oral microbiome is associated with the progression of various systemic diseases, including diabetes. However, the precise causal relationships remain elusive. This study aims to investigate the potential causal associations between oral microbiome and type 2 diabetes (T2D) using Mendelian randomization (MR) analyses.MethodsWe conducted bidirectional two-sample MR analyses to investigate the impact of oral microbiome from saliva and the tongue T2D. This analysis was based on metagenome-genome-wide association studies (mgGWAS) summary statistics of the oral microbiome and a large meta-analysis of GWAS of T2D in East Asian populations. Additionally, we utilized the T2D GWAS summary statistics from the Biobank Japan (BBJ) project for replication. The MR methods employed included Wald ratio, inverse variance weighting (IVW), weighted median, MR-Egger, contamination mixture (ConMix), and robust adjusted profile score (RAPS).ResultsOur MR analyses revealed genetic associations between specific bacterial species in the oral microbiome of saliva and tongue with T2D in East Asian populations. The MR results indicated that nine genera were shared by both saliva and tongue. Among these, the genera Aggregatibacter, Pauljensenia, and Prevotella were identified as risk factors for T2D. Conversely, the genera Granulicatella and Haemophilus D were found to be protective elements against T2D. However, different species within the genera Catonella, Lachnoanaerobaculum, Streptococcus, and Saccharimonadaceae TM7x exhibited multifaceted influences; some species were positively correlated with the risk of developing T2D, while others were negatively correlated.DiscussionThis study utilized genetic variation tools to confirm the causal effect of specific oral microbiomes on T2D in East Asian populations. These findings provide valuable insights for the treatment and early screening of T2D, potentially informing more targeted and effective therapeutic strategies.
Preparation and characterization of Al-12Si/ceramic composite phase change heat storage material
Authors: Zhang Gaoqun , Duan Dabo , Zhang Jingcen , Hao Junjie , Deng Zhanfeng 
Published: August 2024

Thermal storage ceramics using metals as phase change materials (PCMs) have both high thermal conductivity and high heat storage density. However, in the process of use is very easy to occur in the metal phase change material leakage, will seriously affect the service life of the thermal storage ceramics. In this study, ceramic composite phase change heat storage materials with Al-12Si alloy as phase change material were prepared. Firstly, Al-12Si was pretreated by sol-gel method and high temperature heat treatment to obtain the pretreated Al-12Si alloy powder with dense alumina shell layer. After that, the pretreated Al-12Si alloy powder was mixed and pressed with alumina, silicon dioxide, magnesium oxide, and mullite respectively, and sintered at 1,100°C, 1,200°C, or 1,300°C. The experimental results show that the metal phase change materials and the four ceramic materials show good chemical compatibility, and pretreated Al-12Si essentially retains its initial shape and is uniformly dispersed in the heat storage material. Among all the samples, the pre-treated Al-12Si/mullite ceramic thermal storage materials with a sintering temperature of 1,200°C showed the best thermal storage performance. The thermal conductivity of the samples was up to 17.94 W/(m·K). The latent heat storage value was 139.51 J/g before thermal cycling, 138.27 J/g after 100 thermal cycling, which was only decreased by 0.89%, and there was almost no alloy leakage. This study has successfully realized that the ceramic thermal storage material possesses high thermal conductivity, high thermal storage density and excellent thermal cycling performance at the same time, and provides a new method for the production and preparation of Al-12Si/ceramic heat storage materials, which has great potential for application in heat storage systems.
Cellular stress increases DRIP production and MHC Class I antigen presentation
Authors: Pach Natalie , Basler Michael 
Published: August 2024

BackgroundDefective ribosomal products (DRiPs) are non-functional proteins rapidly degraded during or after translation being an essential source for MHC class I ligands. DRiPs are characterized to derive from a substantial subset of nascent gene products that degrade more rapidly than their corresponding native retiree pool. So far, mass spectrometry analysis revealed that a large number of HLA class I peptides derive from DRiPs. However, a specific viral DRiP on protein level was not described. In this study, we aimed to characterize and identify DRiPs derived from a viral protein.MethodsUsing the nucleoprotein (NP) of the lymphocytic choriomeningitis virus (LCMV) which is conjugated N–terminally to ubiquitin, or the ubiquitin-like modifiers FAT10 or ISG15 the occurrence of DRiPs was studied. The formation and degradation of DRiPs was monitored by western blot with the help of a FLAG tag. Flow cytometry and cytotoxic T cells were used to study antigen presentation.ResultsWe identified several short lived DRiPs derived from LCMV-NP. Of note, these DRiPs could only be observed when the LCMV–NP was modified with ubiquitin or ubiquitin-like modifiers, but not in the wild type form. Using proteasome inhibitors, we could show that degradation of LCMV-NP derived DRiPs were proteasome dependent. Interestingly, the synthesis of DRiPs could be enhanced when cells were stressed with the help of FCS starvation. An enhanced NP118–126 presentation was observed when the LCMV-NP was modified with ubiquitin or ubiquitin-like modifiers, or under FCS starvation.ConclusionTaken together, we visualize for the first time DRiPs derived from a viral protein. Furthermore, DRiPs formation, and therefore MHC-I presentation, is enhanced under cellular stress conditions. Our investigations on DRiPs in MHC class I antigen presentation open up new approaches for the development of vaccination strategies.