bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
Authors: Hung Ching‐Hsia , Chan Shih‐Hung , Chu Pei‐Ming , Tsai Kun‐Ling 
Published: July 2015

ScopeAtherosclerosis is believed to be an independent predictor of cardiovascular diseases. A growing body of evidence suggests that quercetin is a potent antioxidant and anti‐inflammatory compound. The molecular mechanisms underlying its protective effects against oxidative stress in human endothelial cells remain unclear. This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate‐oxidase (NADPH oxidase) and free radicals.Methods and resultsHuman umbilical vein endothelial cells were treated with oxLDL with or without quercetin pretreatment. We found that quercetin pretreatment increased SIRT1 mRNA expression. In fact, quercetin protected against oxLDL‐impaired SIRT1 and AMPK activities and reduced oxLDL‐activated NOX2 and NOX4. However, silencing SIRT1 and AMPK diminished the protective function of quercetin against oxidative injuries. The results also indicated that oxLDL suppressed AKT/endothelial NO synthase, impaired mitochondrial dysfunction, and enhanced reactive oxygen species formation, activating the Nuclear Factor Kappa B (NF‐κB) pathway.ConclusionThese results provide new insight regarding the possible molecular mechanisms of quercetin. Quercetin suppresses oxLDL‐induced endothelial oxidative injuries by activating SIRT1 and modulating the AMPK/NADPH oxidase/AKT/endothelial NO synthase signaling pathway.
Digestibility of gluten proteins is reduced by baking and enhanced by starch digestion
Authors: Smith Frances , Pan Xiaoyan , Bellido Vincent , Toole Geraldine A. , Gates Fred K. , Wickham Martin S. J. , Shewry Peter R. , Bakalis Serafim , Padfield Philip , Mills E. N. Clare 
Published: July 2015

ScopeResistance of proteins to gastrointestinal digestion may play a role in determining immune‐mediated adverse reactions to foods. However, digestion studies have largely been restricted to purified proteins and the impact of food processing and food matrices on protein digestibility is poorly understood.Methods and resultsDigestibility of a total gliadin fraction (TGF), flour (cv Hereward), and bread was assessed using in vitro batch digestion with simulated oral, gastric, and duodenal phases. Protein digestion was monitored by SDS‐PAGE and immunoblotting using monoclonal antibodies specific for celiac‐toxic sequences (QQSF, QPFP) and starch digestion by measuring undigested starch. Whereas the TGF was rapidly digested during the gastric phase the gluten proteins in bread were virtually undigested and digested rapidly during the duodenal phase only if amylase was included. Duodenal starch digestion was also slower in the absence of duodenal proteases.ConclusionThe baking process reduces the digestibility of wheat gluten proteins, including those containing sequences active in celiac disease. Starch digestion affects the extent of protein digestion, probably because of gluten‐starch complex formation during baking. Digestion studies using purified protein fractions alone are therefore not predictive of digestion in complex food matrices.
Estimating the prevalence of any impairing childhood mental disorder in the national health interview survey
Authors: Ringeisen Heather , Aldworth Jeremy , Colpe Lisa J. , Pringle Beverly , Simile Catherine 
Published: July 2015

AbstractThis study investigates whether the six‐item Strengths and Difficulties Questionnaire SDQ (five symptoms and one impact item) included in the National Health Interview Survey (NHIS) can be used to construct models that accurately estimate the prevalence of any impairing mental disorder among children 4–17 years old as measured by a shortened Child/Adolescent or Preschool Age Psychiatric Assessment (CAPA or PAPA). A subsample of 217 NHIS respondents completed a follow‐up CAPA or PAPA interview. Logistic regression models were developed to model presence of any child mental disorder with impairment (MDI) or with severe impairment (MDSI). Models containing only the SDQ impact item exhibited highly biased prevalence estimates. The best‐performing model included information from both the five symptom SDQ items and the impact item, where absolute bias was reduced and sensitivity and concordance were increased. This study illustrates the importance of using all available information from the six‐item SDQ to accurately estimate the prevalence of any impairing childhood mental disorder from the NHIS. Copyright © 2015 John Wiley & Sons, Ltd.
Nerve ultrasound identifies abnormalities in the posterior interosseous nerve in patients with proximal radial neuropathies
Authors: Dietz Alexander R. , Bucelli Robert C. , Pestronk Alan , Zaidman Craig M. 
Published: July 2015

ABSTRACTIntroduction: The radial nerve and posterior interosseous nerve (PIN) are prone to injury at multiple sites. Electrodiagnostic (EDx) studies may only identify the most proximal lesion. Nerve ultrasound could augment EDx by visualizing additional pathology. Methods: This investigation was a retrospective examination of ultrasound and EDx from 26 patients evaluated for posterior cord/radial/PIN lesions. Results: Eighteen of 26 patients had abnormalities on EDx (15 radial, 2 PIN, 1 posterior cord). Ultrasound identified 15 of 18 (83%) of the EDx abnormalities and provided additional diagnostic information. In 6 of 15 (40%) patients with EDx evidence of radial neuropathy, ultrasound identified both radial nerve enlargement and additional, unsuspected PIN enlargement (53% to 339% enlarged vs. unaffected side). Ultrasound also identified: nerve (dis)continuity at the trauma site (n = 8); and nerve tumor (n = 2; 1 with normal EDx). Conclusion: In radial neuropathy, ultrasound often augments EDx studies and identifies a second lesion in the PIN. Further studies are required to determine the etiology and significance of this additional distal pathology. Muscle Nerve 53: 379–383, 2016
Increased frequency of rhabdomyolysis in familial dysautonomia
Authors: Palma Jose‐alberto , Roda Ricardo , Norcliffe‐kaufmann Lucy , Kaufmann Horacio 
Published: July 2015

ABSTRACTIntroduction:Familial dysautonomia (FD; OMIM # 223900) is an autosomal recessive disease with features of impaired pain and temperature perception and lack of functional muscle spindles. After 3 FD patients presented with rhabdomyolysis in a short time span, we aimed to determine the frequency of rhabdomyolysis is this population. Methods: This study was a retrospective chart review of 665 FD patients. Results: Eight patients had at least 1 episode of rhabdomyolysis. Two patients had 2 episodes. The average incidence of rhabdomyolysis in FD was 7.5 per 10,000 person‐years. By comparison, the average incidence with statins has been reported to be 0.44 per 10,000 person‐years. Mean maximum creatine kinase (CK) level was 32,714 ± 64,749 U/L. Three patients had hip magnetic resonance imaging showing gluteal hyperintensities. Conclusions: Patients with FD have an increased incidence of rhabdomyolysis. We hypothesize that this may result from a combination of absent functional muscle spindles and muscle mitochondrial abnormalities. Muscle Nerve, 2015
Application of copper thiocyanate for high open‐circuit voltages of CdTe solar cells
Authors: Paudel Naba R. , Yan Yanfa 
Published: July 2015

AbstractCopper thiocyanate (CuSCN) has proven to be a low‐cost, efficient hole‐transporting material for the emerging organic–inorganic perovskite solar cells. Herein, we report that CuSCN can also be applied to CdTe thin‐film solar cells to achieve high open‐circuit voltages (VOCs). By optimizing the thickness of the thermally evaporated CuSCN films, CdTe cells fabricated by close space sublimation in the superstrate configuration have achieved VOCs as high as 872 mV, which is about 20–25 mV higher than the highest VOC for the reference cells using the standard Cu/Au back contacts. CuSCN is a wide bandgap p‐type conductor with a conduction band higher than that of CdTe, leading to a conduction band offset that reflects electrons in CdTe, partially explaining the improved VOCs. However, due to the low conductivity of CuSCN, CdTe cells using CuSCN/Au back contacts exhibited slightly lower fill factors than the cells using Cu/Au back contacts. With optimized CdS:O window layers, the power conversion efficiency of the best CdTe cell, using CuSCN/Au back contact, is 14.7%: slightly lower than that of the best cell (15.2%) using Cu/Au back contact. Copyright © 2015 John Wiley & Sons, Ltd.
Temperature influences the level of glyphosate resistance in barnyardgrass (Echinochloa colona)
Authors: Nguyen Thai Hoan , Malone Jenna M , Boutsalis Peter , Shirley Neil , Preston Christopher 
Published: July 2015

AbstractBACKGROUNDEchinochloa colona is an important summer‐growing weed species in cropping regions of northern Australia that has evolved resistance to glyphosate owing to intensive use of this herbicide in summer fallow.RESULTSPot trials conducted at 20 and 30 °C on six E. colona populations showed a significant increase in the level of glyphosate resistance in resistant populations at 30 °C compared with 20 °C. However, there was no influence of growth temperature on glyphosate susceptibility of the sensitive population. Sequencing of the target‐site gene (EPSPS) of the six populations identified a mutation at position 106 leading to a change from proline to serine in the most resistant population A533.1 only. EPSPS gene amplification was not detected in any of the resistant populations examined. Examining 14C‐glyphosate uptake on two resistant and one susceptible population showed a twofold increase at 20 °C; however, few differences in glyphosate translocation occurred from the treated leaf to other plant parts between populations or temperatures.CONCLUSIONThere is reduced efficacy of glyphosate at high temperatures on resistant E. colona populations, making these populations harder to control in summer. © 2015 Society of Chemical Industry
Photochemical degradation of imazosulfuron under simulated California rice field conditions
Authors: Rering Caitlin C , Gonzalez Monica A , Keener Megan R , Ball David B , Tjeerdema Ronald S 
Published: July 2015

AbstractBACKGROUNDThe photodegradation of imazosulfuron (IMZ), a potent broad‐spectrum herbicide, was investigated under simulated rice field conditions. Previous reports have indicated that it is photolabile, but have failed to report radiation intensity or determine a quantum yield, precluding extrapolation to environmental rates. Therefore, the objective of this investigation was to determine the photolytic rate of IMZ under simulated rice field conditions and how it is influenced by environmental factors such as turbidity, salinity and temperature.RESULTSIMZ was efficiently photolyzed in all solutions and fitted pseudo‐first‐order kinetics. Degradation was faster in HPLC‐grade water than in field water. Field‐relevant variances in temperature, turbidity and salinity did not significantly influence degradation. The experimentally derived quantum yield for direct photolysis (2.94 × 103) was used to predict the half‐life of IMZ in a California rice field (3.6 days).CONCLUSIONSAqueous photolysis is predicted to be an important process in the overall degradation of IMZ in the environment, regardless of variances in salinity, organic matter and temperature. Based on the predicted half‐life of IMZ in a California rice field (3.6 days), state‐mandated holding periods for field water post‐IMZ application (30 days) are expected to allow for sufficient clearance of the herbicide (>98%), preventing significant contamination of the environment upon release of tailwater. © 2015 Society of Chemical Industry
Transperitoneal robotic resection of benign primary retroperitoneal tumors: can it be widely used?
Authors: Zhang Tian , Wang Xinjing , Zhao Liangchao , Liu Fei , Chen Hao , Deng Xiaxing , Peng Chenghong , Shen Baiyong 
Published: July 2015

AbstractBackgroundThis article was aimed to show the safety, flexibility and other advantages of transperitoneal robot‐assisted resection of benign primary retroperitoneal tumors.MethodsTen patients underwent robotic surgeries, and 31 underwent laparotomy surgeries from 2012 to 2014. The perioperative data, including tumor size, operation time, and other parameters were analyzed.ResultsThe tumor sizes of the two groups were not different (robotic group vs laparotomy group: 5.47 vs 5.32 cm, respectively; P = 0.777). The differences in the blood loss (robotic group vs laparotomy group: 80.00 vs. 146.08 mL, respectively; P = 0.021), time of oral intake (robotic group vs laparotomy group: 2.12 vs. 3.42 d, respectively; P = 0.045) and post‐operation hospital stay (robotic group vs laparotomy group: 5.40 vs. 8.77 d, respectively; P = 0.004) were statistically significant and lower in the robotic group.ConclusionRobot‐assisted resection of benign retroperitoneal tumors is flexible and safe and provides better protection when complex lesions are removed. Copyright © 2015 John Wiley & Sons, Ltd.
Identity‐based signcryption from lattices
Authors: Yan Jianhua , Wang Licheng , Dong Mianxiong , Yang Yixian , Yao Wenbin 
Published: July 2015

AbstractSigncryption as a cryptographic primitive can carry out signature and encryption simultaneously at a remarkably reduced cost. Identity‐based cryptography is more convenient than public key infrastructure‐based cryptography in certificate management. As a result, identity‐based signcryption has been studied extensively, and many efficient and provably secure constructions have been proposed. However, most of these schemes are based on intractability assumptions from number theory, and these assumptions have been threatened by the booming quantum computation. Therefore, a recent trend in cryptography is to construct cryptosystems that are based on lattice‐based intractability assumptions because of their plausible features of quantum attack resistance. In this paper, several identity‐based signcryption schemes from lattice hardness assumptions are proposed. In the standard model, these schemes are indistinguishable against inner adaptively chosen ciphertext attacks (IND‐CCA2) and strongly unforgeable against inner chosen message attacks. In our construction, it does not matter whether the original encryption scheme used to construct signcryption is deterministic or probabilistic; the resulted signcryption schemes can reach IND‐CCA2 security. To achieve this, we carefully combine three techniques—the identity‐based encryption from lattice due to Agrawal–Boneh–Boyen (EUROCRYPT 2010), the framework of lattice‐based short signature due to Boyen (Public Key Cryptography 2010), and the Canetti–Halevi–Katz (abbr. CHK) technique, with necessary and tailored optimization—for transforming an (ℓ + 1)‐level indistinguishable under chosen plaintext attack secure hierarchical identity‐based encryption (HIBE) into an ℓ level IND‐CCA2 secure HIBE scheme. In addition, our security proof also contains a more efficient simulation tool that might have separate interest in cryptographic applications. Copyright © 2015 John Wiley & Sons, Ltd.
K‐anonymity against neighborhood attacks in weighted social networks
Authors: Liu Chuan‐Gang , Liu I‐Hsien , Yao Wun‐Sheng , Li Jung‐Shian 
Published: July 2015

AbstractNowadays, with the advance of Internet technology, social network is getting popular, which combines the virtual network and the real world. People employ this network to communicate with all social things of their interest, including shopping, making friends, sharing experiences of life, and so on. In social networks, the social data expands rapidly and the malicious users can easily get the social data. With the social information, they could conjecture the relationship among social network data via the systematical analysis tool. Hence, the personal privacy data in social network may be exposed to some unknown risks, and recently, these issues arising in such a network catch much attention. The protection of personal privacy social data becomes an important and urgent research in social networks. One of personal privacy social information is the relations between the individuals and their social groups, namely human relationships.Neighborhood attacks are incident to the exposure of human relationships. Previous studies try to conceal human relationships information with well‐known k‐anonymity protection to resist this attack in social networks. However, those researches do not take care of those attacks in weighted social network, which does not make sense due to the fact that people should have different relationships with different persons. In such weighted social network, the edge denotes the human relationship and the weight denotes the degree of this human relationship in social networks. Our study focuses on the k‐anonymity protection scheme in weighted social networks, and our scheme can achieve k‐anonymity protection under the expected conditions, less virtual edges added and fewer weights changed. Through the analysis with MATLAB tool, we show that our k‐anonymity algorithm can achieve high anonymity protection rate under various k‐anonymity policies. Copyright © 2015 John Wiley & Sons, Ltd.
Lightweight security against combined IE and SSDF attacks in cooperative spectrum sensing for cognitive radio networks
Authors: Sucasas Victor , Althunibat Saud , Radwan Ayman , Marques Hugo , Rodriguez Jonathan , Vahid Seiamak , Tafazolli Rahim , Granelli Fabrizio 
Published: July 2015

AbstractCognitive radio is envisaged as a promising solution to cope with the problem of spectrum scarcity. In cognitive radio networks, users can sense the medium and opportunistically use available frequency bands. Users can cooperate in order to increase the reliability of the sensing process, which is called cooperative spectrum sensing (CSS). However, cooperative paradigms are threatened by the behavior of malicious users. Two types of attacks represent the main threats for CSS network operation, namely, spectrum sensing data falsification (SSDF) and incumbent emulation (IE). These two types of attacks have received a considerable amount of attention in the literature, but they have always been studied separately. In this paper, we propose a novel mechanism based on lightweight cryptography that considers both SSDF and IE attacks combined in a CSS network for the first time. Lightweight cryptography, in contrast to previous techniques used (such as intrusion detection or reputation systems), provides higher resilience to such attacks when a high number of mobile malicious users exist, providing better energy efficiency. Analytical and simulation results show the outperformance of the proposed algorithm compared with previous mechanisms, in terms of lower false alarm probability (i.e., higher chance of using the free frequency bands) and hence better energy ratings. Copyright © 2015 John Wiley & Sons, Ltd.
Estimating fixed‐end rotations of reinforced concrete members at yielding and ultimate
Authors: Mergos Panagiotis E. , Kappos Andreas J. 
Published: July 2015

AbstractStrain penetration of the longitudinal reinforcement in reinforced concrete (RC) members at the joints and/or footings results in fixed‐end rotations at the member ends. Several experimental studies have shown that fixed‐end rotations caused by strain penetration contribute significantly (up to 50 %) to the total displacement capacity of RC members. Hence, accurate determination of these fixed‐end rotations at yielding and ultimate limit states is of primary importance when defining the structural response of RC members. The purpose of this study is to present the theoretical background to and the assumptions made for the most common relationships found in the literature for determining strain penetration‐induced fixed‐end rotations at yielding and ultimate. Furthermore, new simple relationships are proposed on the basis of realistic and mechanically based assumptions. Comparisons between the existing and proposed relationships demonstrate the limitations of the former. Finally, the proposed relationships are calibrated against experimental measurements of RC column specimens subjected to cyclic loading with recorded fixed‐end rotations due to strain penetration in the adjacent joints and/or footings.
Vibrational Raman Shifts and Aromaticity: The Case of Oligothiophenes
Authors: Casado Juan , Hernández Víctor , López Navarrete Juan T. 
Published: July 2015

AbstractA general description of the use of the Raman spectra of polyconjugated molecules to infer their electronic and molecular properties and how these change in a number of situations is illustrated with several examples, with particular emphasis on oligothiophene molecules. The most noticeable features of the Raman spectra of these molecules and the main theoretical models developed for their understanding have been revised and explained in terms related to π‐electron delocalization intimately connected with the aromatic and quinoidal characters.
Successful pregnancy by vitrified–warmed embryo transfer for a woman with Kallmann syndrome
Authors: Shimoda Misato , Iwayama Hiroshi , Ishiyama Mai , Nakatani Ayano , Yamashita Masanori 
Published: July 2015

AbstractPurposeKallmann syndrome is a genetic disorder characterized by hypogonadotropic hypogonadism and anosmia. We report the case of a 31‐year‐old woman with Kallmann syndrome who successfully gave birth after intracytoplasmic sperm injection (ICSI) and vitrified–warmed embryo transfer, despite relatively ineffective ovarian stimulation.MethodA 30 year‐old woman with primary amenorrhea wished to achieve pregnancy. Diagnostic testing results were consistent with Kallmann syndrome. Follicular stimulation was started with human menopausal gonadotropin (hMG; 150 IU/day). After 28 days of treatment, 4 follicles were observed (total hMG; 4200 IU), with a dominant follicle diameter of 23 mm. Ovum pick‐up was performed and 2 oocytes, one at metaphase II (MII) and one at the germinal vesicle stage, were obtained. Piezo‐ICSI was performed on the MII oocyte and an 8‐cell stage embryo was cryopreserved on day 3. Subsequently, embryo transfer was performed after endometrial preparation.ResultA gestational sac and embryo heart activity were confirmed by ultrasonographic monitoring, and a healthy male infant weighing 3246 g was delivered by Caesarean section after 41 weeks 3 days of gestation.ConclusionThis is the first report of a healthy delivery after vitrified–warmed embryo transfer for a woman with Kallmann syndrome. Our experience suggests that ICSI and vitrified–warmed embryo transfer are effective for women with Kallmann syndrome.