bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulfur Cinquefoil (Potentilla recta) Response to Defoliation on Foothill Rangeland
Authors: Frost Rachel A. , Mosley Jeffrey C. 
Published: November 2012

AbstractSulfur cinquefoil is an invasive, perennial forb on rangelands of western Canada and the United States. Sulfur cinquefoil reproduces solely by seed and it is a prolific seed producer. Our 2-yr study (2006, 2007) investigated the optimal timing and intensity of defoliation to decrease aboveground productivity and seed production of sulfur cinquefoil plants on foothill rangeland in southwestern Montana. Each year, 150 sulfur cinquefoil plants within a 430-m2 enclosure were tagged for identification and randomly assigned to one of 15 clipping treatments with 10 plants per treatment. Clipping treatments were conducted at three timings: (preflower [early June], flowering [late June], and seedset [mid-July]) and all possible combinations of timings for a total of seven timing treatments clipped to two stubble heights (7.5 cm or 15 cm), comprising 14 unique treatments. The final (15th) treatment consisted of an unclipped control. Response variables collected at senescence (late July) included aboveground biomass; number of buds, flowers and fruits on each plant; and number and viability of seeds produced. Results indicated that defoliation of sulfur cinquefoil can effectively reduce its yield and seed production. All clipping treatments reduced aboveground biomass of sulfur cinquefoil compared with control plants (P ≤ 0.05), except clipping to 15 cm during preflowering in the wetter year of 2006. Clipping to either 7.5 cm or 15 cm at all times or combinations of timings reduced the number of buds, flowers, fruits, and seeds produced by sulfur cinquefoil (P ≤ 0.05). Viable seed production was reduced 99 to 100% when plants were clipped once to either 7.5 or 15 cm during flowering or seedset. Results suggest that targeted livestock grazing or mowing applied one time per season during flowering or seedset could effectively suppress the biomass production and viable seed production of sulfur cinquefoil.
The Influence of Chilling and Chipping of Star-of-Bethlehem (Ornithogalum umbellatum) Bulbs on Plant Growth and Reproduction
Authors: Johanning Nathan R. , Preece John E. , Young Bryan G. 
Published: November 2012

AbstractGreenhouse studies were conducted on two southern Illinois star-of-Bethlehem populations to determine the influence of chilling and bulb chipping on plant growth and reproduction. Chilling was not required for leaf emergence of dormant bulbs, but an increase to 10 wk of chilling proportionally delayed leaf emergence by 41 and 42 d for the Murphysboro and the Marion populations, respectively. Bulb chipping did reduce plant height when compared to plants from nonchipped bulbs. Also, chipped bulbs produced a greater number of small daughter bulbs compared to nonchipped bulbs; however, total bulblet production was variable and dependent on population, mother bulb size, and chipping treatment. Overall, bulb chipping did not have any negative influence on star-of-Bethlehem and might promote increased daughter bulblet production. Therefore, field operations, such as tillage, that cut and chip bulbs might actually accentuate both the spread and density of star-of-Bethlehem infestations.
A comparison of second premolar extraction and mini-implant total arch distalization with interproximal stripping
Authors: Jung Min-Ho 
Published: November 2012

ABSTRACT

Objective:
The effect of total arch distalization using orthodontic mini-implants (OMIs) combined with interproximal stripping (IPS) and second premolar extraction was investigated in Class I malocclusion patients.

Materials and Methods:
A total of 66 consecutively treated Class I malocclusion (Class I molar relationship; 0 mm &lt; overbite and overjet &lt; 4.5 mm) patients ranging in age from 17 to 44 years who received single-phase treatment were included in this study. Pre- and posttreatment lateral cephalograms and dental casts were measured and compared statistically.

Results:
In the distalization with IPS group, 3.6 mm and 3.8 mm of crowding in the upper and lower arches, respectively, were resolved, and 3.8 mm and 3.2 mm of upper and lower incisor retraction, respectively, were achieved simultaneously by the treatment. As a result of the second premolar extraction treatment, 3.9 mm and 3.6 mm of crowding in the upper and lower arches, respectively, were resolved, and 3.3 mm and 3.2 mm of incisor retraction, respectively, were achieved during treatment. There was no statistically significant difference in the amount of crowding and incisor retraction between the two groups.

Conclusions:
Total arch distalization using an OMI with IPS did not yield a significantly different treatment result compared to second premolar extraction treatment.
Common Fibular (Peroneal) Neuropathy as the Result of a Ganglion Cyst
Authors: Mulligan Edward P. , McCain Karen 
Published: November 2012

The patient was a 61-year-old woman who was referred to a physical therapist with a diagnosis of right common fibular neuropathy at the fibular head involving both the deep and superficial nerve branches. Physical therapist intervention included fitting the patient with a right ankle-foot orthosis and referring the patient to her physician due to concern for a potential compressive lesion at the right proximal tibiofibular joint. Subsequent magnetic resonance imaging identified a lobulated, fluid-filled mass likely representing a ganglion cyst. J Orthop Sports Phys Ther 2012;42(12):1051. doi:10.2519/jospt.2012.0421
Watteau et Marivaux : deux témoins d'une mutation du sentiment amoureux au XVIIIe siècle
Authors: Duccini Hélène 
Published: November 2012

Résumé Watteau (1684-1721) et Marivaux (1688-1763) sont tous deux contemporains et témoins d’une mutation de l’expression du sentiment amoureux au début du xviii e siècle. Ils expriment dans leurs œuvres et avec des moyens différents ces changements. Le « marivaudage » est déjà présent dans les « fêtes galantes », nouveau genre, qui prend sa place dans la série de ceux reconnus par l’Académie de peinture, avec la réception de L’Embarquement pour Cythère que Watteau présente en 1718. Dans ses deux versions (celle du Louvre, puis celle de Berlin) du voyage vers Cythère, l’île qui a vu naître Vénus des flots de la mer, Watteau traduit les étapes du sentiment amoureux qui commence par des aveux chuchotés, puis s’épanouit dans une déclaration avant de permettre aux couples ainsi formés de prendre le large vers Cythère. Le théâtre de Marivaux est lui aussi marqué par cette forme nouvelle de l’expression du sentiment amoureux, plus personnel, plus respectueux du partenaire ou de la partenaire. Dans la conquête de la liberté propre au xviii e siècle, le choix du conjoint devient l’apanage des futurs mariés et leur sentiment finit par l’emporter sur les intérêts matériels des familles et le souci des lignages. Les pères ont leur mot à dire, mais les enfants ont le droit d’avoir eux-mêmes leur préférence. Le peintre et l’homme de théâtre, témoins de cette évolution, lui donnent une expression nouvelle dans des paysages mélancoliques et, au théâtre, dans les dialogues des « Jeux de l’Amour et du hasard ».
Dix heures et demie du soir à la radio : l'amour sur les ondes
Authors: Deleu Christophe 
Published: November 2012

Résumé Est-il possible de parler d’amour à la radio ? À l’époque d’Internet, marqué par l’imbrication de la sphère privée et de la sphère publique, on pourrait présupposer qu’il n’existe plus de limite à la liberté d’expression dans les médias. Nous voudrions au contraire montrer que notre paysage radiophonique reste très surveillé. Et que ce sont les sujets d’ordre sexuel qui sont les plus encadrés, et qui suscitent le plus de controverses. Pour cela, nous montrons dans quel contexte socioculturel les thématiques relatives à la sexualité sont apparues à la radio, et comment les pouvoirs publics ont été amenés à réguler la liberté d’expression (rôle dévolu aujourd’hui au Conseil supérieur de l’audiovisuel). Retracer l’émergence de la sexualité à la radio et étudier les décisions du CSA en matière de liberté d’expression permet de dessiner la frontière, aux contours parfois flous, entre ce qui dicible à la radio et ce qui est encore considéré comme attentatoire à l’ordre public.
Cutting Edge: Tumor-Targeting Antibodies Enhance NKG2D-Mediated NK Cell Cytotoxicity by Stabilizing NK Cell–Tumor Cell Interactions
Authors: Deguine Jacques , Breart Béatrice , Lemaître Fabrice , Bousso Philippe 
Published: November 2012

Abstract
Monoclonal antibodies represent a promising approach to fight a variety of tumors, but their mode of action remains to be fully understood. NK cells can recognize Ab-coated targets, as well as stress ligands, on tumor cells. In this study, we investigated how NK cells integrate both kinds of activating signals. NK cell–mediated killing was maximal with the combined recognition of NKG2D ligands and Ab; surprisingly, only NKG2D engagement substantially enhanced degranulation. Conversely, Ab recognition by NK cells uniquely increased contact stability with tumor cells. Furthermore, using intravital imaging of solid tumors, we showed that Ab recognition favored prolonged interactions between NK cells and targets. Altogether, our results demonstrate that NK cell–mediated killing can be differentially regulated at the level of degranulation and contact stability by distinct activating receptors. Thus, complementary signals mediated by recognition of stress ligands and tumor-specific Abs may contribute to the efficacy of NK cells during mAb therapy.
MARCO Is Required for TLR2- and Nod2-Mediated Responses to Streptococcus pneumoniae and Clearance of Pneumococcal Colonization in the Murine Nasopharynx
Authors: Dorrington Michael G. , Roche Aoife M. , Chauvin Sarah E. , Tu Zhongyuan , Mossman Karen L. , Weiser Jeffrey N. , Bowdish Dawn M. E. 
Published: November 2012

Abstract
Streptococcus pneumoniae is a common human pathogen that accounts for &gt;1 million deaths every year. Colonization of the nasopharynx by S. pneumoniae precedes pulmonary and other invasive diseases and, therefore, is a promising target for intervention. Because the receptors scavenger receptor A (SRA), macrophage receptor with collagenous structure (MARCO), and mannose receptor (MR) have been identified as nonopsonic receptors for S. pneumoniae in the lung, we used scavenger receptor knockout mice to study the roles of these receptors in the clearance of S. pneumoniae from the nasopharynx. MARCO−/−, but not SRA−/− or MR−/−, mice had significantly impaired clearance of S. pneumoniae from the nasopharynx. In addition to impairment in bacterial clearance, MARCO−/− mice had abrogated cytokine production and cellular recruitment to the nasopharynx following colonization. Furthermore, macrophages from MARCO−/− mice were deficient in cytokine and chemokine production, including type I IFNs, in response to S. pneumoniae. MARCO was required for maximal TLR2- and nucleotide-binding oligomerization domain–containing (Nod)2-dependent NF-κB activation and signaling that ultimately resulted in clearance. Thus, MARCO is an important component of anti-S. pneumoniae responses in the murine nasopharynx during colonization.
Optimization-Based String Method for Finding Minimum Energy Path
Authors: Samanta Amit , E Weinan 
Published: November 2012

AbstractWe present an efficient algorithm for calculating the minimum energy path (MEP) and energy barriers between local minima on a multidimensional potential energy surface (PES). Such paths play a central role in the understanding of transition pathways between metastable states. Our method relies on the original formulation of the string method [Phys. Rev. B, 66,052301 (2002)], i.e. to evolve a smooth curve along a direction normal to the curve. The algorithm works by performing minimization steps on hyperplanes normal to the curve. Therefore the problem of finding MEP on the PES is remodeled as a set of constrained minimization problems. This provides the flexibility of using minimization algorithms faster than the steepest descent method used in the simplified string method [J. Chem. Phys., 126(16), 164103 (2007)]. At the same time, it provides a more direct analog of the finite temperature string method. The applicability of the algorithm is demonstrated using various examples.
On Arbitrary-Lagrangian-Eulerian One-Step WENO Schemes for Stiff Hyperbolic Balance Laws
Authors: Dumbser Michael , Uuriintsetseg Ariunaa , Zanotti Olindo 
Published: November 2012

AbstractIn this article we present a new family of high order accurate Arbitrary Lagrangian-Eulerian one-step WENO finite volume schemes for the solution of stiff hyperbolic balance laws. High order accuracy in space is obtained with a standard WENO reconstruction algorithm and high order in time is obtained using the local space-time discontinuous Galerkin method recently proposed in [20]. In the Lagrangian framework considered here, the local space-time DG predictor is based on a weak formulation of the governing PDE on a moving space-time element. For the space-time basis and test functions we use Lagrange interpolation polynomials defined by tensor-product Gauss-Legendre quadrature points. The moving space-time elements are mapped to a reference element using an isoparametric approach, i.e. the space-time mapping is defined by the same basis functions as the weak solution of the PDE. We show some computational examples in one space-dimension for non-stiff and for stiff balance laws, in particular for the Euler equations of compressible gas dynamics, for the resistive relativistic MHD equations, and for the relativistic radiation hydrodynamics equations. Numerical convergence results are presented for the stiff case up to sixth order of accuracy in space and time and for the non-stiff case up to eighth order of accuracy in space and time.
Factors that Affect the Adhesion of Probiotics Bacteria to Resist Rice Starch
Authors: Eswai Ghalia Salem M. , Hassan Zaiton , Abubakr Maryam A. S. 
Published: November 2012

Prebiotics such as resistant starch can be included with probiotics to increase their survival during processing. In this study lactic acid bacteria (LAB) isolated from several sources (yoghurt, banana, and human breast milk) were screened for their probiotic properties. Ten species of bacteria overcame the stress to pH 3 and 0.3% bile. The adhesion properties of these LABs to resistant rice starch (RRS) were investigated. All 10 species of bacteria adhered to RRS within 60 min of exposure. Isolates Bn1 and HM2 were highly adhered to RRS with a total of 79% and 77% of the cells adhering, respectively. Moderate adherent was observed by isolates, YN(70%), CY(48%), FY(55%), HM1(61,5%), HM3(65%), and HM4(50,5%), while isolate YD and Bn2 were poorly adhered to RRS (< 40%adherent). Bacteria adhesion to RRS was positively correlated to time but not to concentration. 37 °C was the ideal temperature for adhesion and Living cells are important for the adhesion.
Angiogenic Dysfunction in Bone Marrow-Derived Early Outgrowth Cells from Diabetic Animals Is Attenuated by SIRT1 Activation
Authors: Yuen Darren A. , Zhang Yanling , Thai Kerri , Spring Christopher , Chan Lauren , Guo Xiaoxin , Advani Andrew , Sivak Jeremy M. , Gilbert Richard E. 
Published: November 2012

Abstract
Impaired endothelial repair is a key contributor to microvascular rarefaction and consequent end-organ dysfunction in diabetes. Recent studies suggest an important role for bone marrow-derived early outgrowth cells (EOCs) in mediating endothelial repair, but the function of these cells is impaired in diabetes, as in advanced age. We sought to determine whether diabetes-associated EOC dysfunction might be attenuated by pharmacological activation of silent information regulator protein 1 (SIRT1), a lysine deacetylase implicated in nutrient-dependent life span extension in mammals. Despite being cultured in normal (5.5 mM) glucose for 7 days, EOCs from diabetic rats expressed less SIRT1 mRNA, induced less endothelial tube formation in vitro and neovascularization in vivo, and secreted less of the proangiogenic ELR+ CXC chemokines CXCL1, CXCL3, and CXCL5. Ex vivo SIRT1 activation restored EOC chemokine secretion and increased the in vitro and in vivo angiogenic activity of EOC conditioned medium derived from diabetic animals to levels similar to that derived from control animals. These findings suggest a pivotal role for SIRT1 in diabetes-induced EOC dysfunction and that its pharmacologic activation may provide a new strategy for the restoration of EOC-mediated repair mechanisms.
Creative Learning Enrichment for Math Appreciation through Time: An Exploratory Pedagogy
Authors: Limjuco Renan P. 
Published: November 2012

This study examined an exploratory pedagogy designed to promote mathematics appreciation through time. It involved an infusion of some creative learning enrichment activities into the traditional approach of teaching, a process believed to heighten the interest of learners to study mathematics. Employing a descriptive method, specifically the longitudinal approach of developmental study, and involving fifteen Electronics Engineering students from a cohesive group, the researcher probed how the unusual non-traditional approaches to mathematics instruction could affect their appreciation for mathematics after 2-year exposure to the pedagogy. Findings revealed that the growth of knowledge precedes the increasing level of mathematics appreciation. Furthermore, learning appreciation maturation is a function of time and exposure to meaningful classroom activities. This study also found that regardless of students’ learning styles, supplementary activities elevate the appreciation of mathematics concepts and improve the analytical skills of the students. Keywords: creative learning enrichment, math appreciation, maturation, pedagogy
Prevalence of Fibromyalgia: A Population‐Based Study in Olmsted County, Minnesota, Utilizing the Rochester Epidemiology Project
Authors: Vincent Ann , Lahr Brian D. , Wolfe Frederick , Clauw Daniel J. , Whipple Mary O. , Oh Terry H. , Barton Debra L. , St. Sauver Jennifer 
Published: November 2012

AbstractObjectiveTo estimate and compare the prevalence of fibromyalgia by 2 different methods in Olmsted County, Minnesota.MethodsThe first method was a retrospective review of medical records of potential cases of fibromyalgia in Olmsted County using the Rochester Epidemiology Project (from January 1, 2005, to December 31, 2009) to estimate the prevalence of diagnosed fibromyalgia in clinical practice. The second method was a random survey of adults in Olmsted County using the fibromyalgia research survey criteria to estimate the percentage of responders who met the fibromyalgia research survey criteria.ResultsOf the 3,410 potential patients identified by the first method, 1,115 had a fibromyalgia diagnosis documented in the medical record by a health care provider. The age‐ and sex‐adjusted prevalence of diagnosed fibromyalgia by this method was 1.1%. By the second method, of the 2,994 people who received the survey by mail, 830 (27.6%) responded and 44 (5.3%) met the fibromyalgia research survey criteria. The age‐ and sex‐adjusted prevalence of fibromyalgia in the general population of Olmsted County by this method was estimated at 6.4%.ConclusionTo the best of our knowledge, this is the first report of the rate at which fibromyalgia is being diagnosed in a community. This is also the first report of prevalence as assessed by the fibromyalgia research survey criteria. Our results suggest that patients, particularly men, who meet the fibromyalgia research survey criteria are unlikely to have been given a diagnosis of fibromyalgia.
Antibody‐Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs
Authors: Secret Emilie , Smith Kevin , Dubljevic Valentina , Moore Eli , Macardle Peter , Delalat Bahman , Rogers Mary‐Louise , Johns Terrance G. , Durand Jean‐Olivier , Cunin Frédérique , Voelcker Nicolas H. 
Published: November 2012

AbstractWe describe the preparation of biodegradable porous silicon nanoparticles (pSiNP) functionalized with cancer cell targeting antibodies and loaded with the hydrophobic anti‐cancer drug camptothecin. Orientated immobilization of the antibody on the pSiNP is achieved using novel semicarbazide based bioconjugate chemistry. To demonstrate the generality of this targeting approach, the three antibodies MLR2, mAb528 and Rituximab are used, which target neuroblastoma, glioblastoma and B lymphoma cells, respectively. Successful targeting is demonstrated by means of flow cytometry and immunocytochemistry both with cell lines and primary cells. Cell viability assays after incubation with pSiNPs show selective killing of cells expressing the receptor corresponding to the antibody attached on the pSiNP.
Down‐regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α–kinoid
Authors: Lauwerys Bernard R. , Hachulla Eric , Spertini François , Lazaro Estibaliz , Jorgensen Christian , Mariette Xavier , Haelterman Edwige , Grouard‐Vogel Géraldine , Fanget Bernard , Dhellin Olivier , Vandepapelière Pierre , Houssiau Frédéric A. 
Published: November 2012

AbstractObjectiveWe developed interferon‐α–kinoid (IFN‐K), a drug composed of inactivated IFNα coupled to a carrier protein, keyhole limpet hemocyanin. In human IFNα–transgenic mice, IFN‐K induces polyclonal antibodies that neutralize all 13 subtypes of human IFNα. We also previously demonstrated that IFN‐K slows disease progression in a mouse model of systemic lupus erythematosus (SLE). This study was undertaken to examine the safety, immunogenicity, and biologic effects of active immunization with IFN‐K in patients with SLE.MethodsWe performed a randomized, double‐blind, placebo‐controlled, phase I/II dose‐escalation study comparing 3 or 4 doses of 30 μg, 60 μg, 120 μg, or 240 μg of IFN‐K or placebo in 28 women with mild to moderate SLE.ResultsIFN‐K was well tolerated. Two SLE flares were reported as serious adverse events, one in the placebo group and the other in a patient who concomitantly stopped corticosteroids 2 days after the first IFN‐K dose, due to mild fever not related to infection. Transcriptome analysis was used to separate patients at baseline into IFN signature–positive and –negative groups, based on the spontaneous expression of IFN‐induced genes. IFN‐K induced anti‐IFNα antibodies in all immunized patients. Notably, significantly higher anti‐IFNα titers were found in signature‐positive patients than in signature‐negative patients. In IFN signature–positive patients, IFN‐K significantly reduced the expression of IFN‐induced genes. The decrease in IFN score correlated with the anti‐IFNα antibody titer. Serum complement C3 levels were significantly increased in patients with high anti‐IFNα antibody titers.ConclusionThese results show that IFN‐K is well tolerated, immunogenic, and significantly improves disease biomarkers in SLE patients, indicating that further studies of its clinical efficacy are warranted.