bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensiveversusstandard follow-up to improve continuous positive airway pressure compliance
Authors: Bouloukaki Izolde , Giannadaki Katerina , Mermigkis Charalampos , Tzanakis Nikolaos , Mauroudi Eleni , Moniaki Violeta , Michelakis Stylianos , Siafakas Nikolaos M. , Schiza Sophia E. 
Published: July 2014

We aimed to compare the effect of intensiveversusstandard interventions on continuous positive airway pressure (CPAP) adherence 2 years after CPAP initiation, as well as on sleepiness, quality of life, depression, hospitalisation and death rate due to cardiovascular disease (CVD).3100 patients with newly diagnosed sleep apnoea were randomised into the standard group, with usual follow-up care, or the intensive group, with additional visits, telephone calls and education. Subjective daytime sleepiness (Epworth Sleepiness Scale; ESS), quality of life (36-item Short Form Health Survey; SF-36) and the patient’s level of depression (Beck Depression Inventory; BDI) were recorded before and 2 years after CPAP initiation, together with CVD hospitalisations and death rate.2 years after CPAP initiation, the intensive group used CPAP significantly more than the standard group (6.9versus5.2 h per night; p<0.001). ESS, SF-36 and BDI scores were also significantly better in the intensive group. Furthermore, the standard group had significantly more deaths and hospitalisations due to CVD.CPAP usage can be improved by both intensive and standard patient support. However, the patients who received intensive CPAP support had significantly better ESS, BDI and SF-36 scores, and lower cardiovascular morbidity and mortality, suggesting that an intensive programme could be worthwhile.
Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma
Authors: Chaudhuri Rekha , McSharry Charles , Brady Jeffrey , Grierson Christal , Messow C. Martina , Spears Mark , Miele Gino , Nocka Karl , MacNee William , Connell Martin , Murchison John T. , Sproule Michael , Hilmi Omar J. , Miller Douglas K. , Thomson Neil C. 
Published: July 2014

Asthmatic smokers have poor symptom control and accelerated decline in lung function. A reduced ratio of matrix metalloproteinase (MMP)-9/tissue inhibitors of metalloproteinases (TIMPs) in nonsmokers with asthma has been implicated in airway remodelling. We tested the hypothesis that sputum MMP-9 activity/TIMPs ratios are reduced in smokers compared with never-smokers with asthma and are associated with reduced lung function and altered computed tomography (CT) measures of airway wall dimensions.Lung function, airway dimensions by CT, and induced sputum concentrations (and activity) of MMP-9 and TIMP-1 and -2 were measured in 81 asthmatics and 43 healthy subjects (smokers and never-smokers). Respiratory epithelialMMP9andTIMPmRNA was quantified in 31 severe asthmatics and 32 healthy controls.Sputum MMP-9 activity/TIMP-1 and TIMP-2 ratios, and nasal epithelialMMP9/TIMP1andMMP9/TIMP2expression ratios were reduced in smokers with asthma compared with never-smokers with asthma. Low sputum ratios in asthmatic smokers were associated with reduced post-bronchodilator forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity ratio and segmental airway lumen area.The association of a low sputum MMP-9 activity/TIMP-1 ratio with persistent airflow obstruction and reduced CT airway lumen area in smokers with asthma may indicate that an imbalance of MMP-9 and TIMPs contributes to structural changes to the airways in this group.
Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD
Authors: Maddocks Matthew , Shrikrishna Dinesh , Vitoriano Simone , Natanek Samantha A. , Tanner Rebecca J. , Hart Nicholas , Kemp Paul R. , Moxham John , Polkey Michael I. , Hopkinson Nicholas S. 
Published: July 2014

Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population.In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU.Mean±sdpercentage intramuscular fat was higher in the patient group (6.7±3.5%versus4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95).Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes.
Trends in hospital admissions for pulmonary embolism in Spain from 2002 to 2011
Authors: de Miguel-Díez Javier , Jiménez-García Rodrigo , Jiménez David , Monreal Manuel , Guijarro Ricardo , Otero Remedios , Hernández-Barrera Valentín , Trujillo-Santos Javier , López de Andrés Ana , Carrasco-Garrido Pilar 
Published: July 2014

The aim of our study was to analyse changes in the incidence, diagnostic procedures, comorbidity, length of hospital stay, costs and in-hospital mortality of patients hospitalised for pulmonary embolism in Spain over a 10-year period.We included all patients who were hospitalised for pulmonary embolism (ICD-9-CM codes 415.11 and 415.19) as the primary diagnosis between 2002 and 2011. Data were collected from the National Hospital Discharge Database, covering the entire Spanish population.115 671 patients were admitted. The overall crude incidence increased from 20.44 per 100 000 inhabitants in 2002 to 32.69 in 2011 (p<0.05). In 2002, 13.3% of patients had a Charlson comorbidity index >2, and in 2011 the prevalence increased to 20.8% (p<0.05). Mean length of hospital stay was 12.7 days in 2002 and decreased to 9.99 in 2011 (p<0.05). During the study period, mean cost per patient increased from €3915 to €4372 (p<0.05). In-hospital mortality decreased from 12.9% in 2002 to 8.32% in 2011 (p<0.05). The increase in the use of computed tomographic pulmonary angiography over time was associated with increased incidence and lower mortality.Our results revealed an increase in the incidence of hospitalised pulmonary embolism patients from 2002 to 2011 with concomitant increase in comorbidities and cost. However, length of hospital stay and in-hospital mortality decreased.
Transcriptome analysis of callus from Picea balfouriana
Authors: Li Qingfen , Zhang Shougong , Wang Junhui 
Published: July 2014

AbstractBackgroundPicea likiangensisvar.balfouriana(Rehd. et Wils.) Hillier ex Slavin (also known asPicea balfouriana) is an ecologically and economically important conifer that grows rapidly under optimum conditions and produces high-quality wood. It has a wide geographic distribution and is prevalent in southwest and eastern regions of China. Under suboptimal conditions,P. balfourianagrows slowly, which restricts its cultivation. Somatic embryogenesis has been used in the mass propagation of commercial species. However, low initiation rates are a common problem and the mechanisms involved in the induction of somatic embryogenesis are not fully understood. To understand the molecular mechanisms regulating somatic embryogenesis inP. balfouriana, high-throughput RNA-seq technology was used to investigate the transcriptomes of embryogenic and non-embryogenic tissues from threeP. balfourianagenotypes. We compared the genes expressed in these tissues to identify molecular markers with embryogenic potential.ResultsA total of 55,078,846 nucleotide sequence reads were obtained for the embryogenic and non-embryogenic tissues ofP. balfouriana, and 49.56% of them uniquely matched 22,295 (84.3%) of the 26,437 genes in thePicea abiesgenome database (Nature 497: 579-584, 2013). Differential gene expression analysis identified 1,418 differentially expressed genes (false discovery rate <0.0001; fold change ≥2) in the embryogenic tissues relative to the non-embryogenic tissues, including 431 significantly upregulated and 987 significantly downregulated genes. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis revealed that the most significantly altered genes were involved in plant hormone signal transduction, metabolic pathways (starch and sucrose metabolism), and phenylalanine metabolism.ConclusionsWe found that the initiation of embryogenic tissues affected gene expression in many KEGG pathways, but predominantly in plant hormone signal transduction, plant-pathogen interaction, and starch and sucrose metabolism. The changes in multiple pathways related to induction in theP. balfourianaembryogenic tissues described here, will contribute to a more comprehensive understanding of the mechanisms involved in the initiation of somatic embryogenesis. Additionally, we found that somatic embryogenesis receptor kinase (SERK), arabinogalactan proteins, and members of the WUS-related homeobox protein family may play important roles and could act as molecular markers in the early stage of somatic embryogenesis, as reported previously.
The clinicopathological significance of neurogenesis in breast cancer
Authors: Zhao Qianqian , Yang Yan , Liang Xizi , Du Guangye , Liu Liwei , Lu Lingjuan , Dong Junbo , Han Hongxiu , Zhang Guohua 
Published: July 2014

Abstract

Background
Recent reports support a novel biological phenomenon about cancer related neurogenesis. However, little is known about the clinicopathological significance of neurogenesis in breast cancer.

Methods
A total of 196 cases, including 20 of normal tissue, 14 of fibroadenoma, 18 of ductal carcinoma in situ (DCIS) and 144 of invasive ductal carcinoma (IDC) of the breast were used. The tissue slides were immunostained for protein gene product (PGP) 9.5 and S 100 to identify nerves. The correlation between the expression of PGP 9.5 and clinicopathological characteristics in IDC of the breast was assessed.

Results
While the PGP 9.5 positive nerve fibers are identified in all cases of normal breast tissue controls and in the tumor stroma of 61% (89/144) cases of invasive ductal carcinomas, PGP 9.5 positive nerve fibers are not seen in the tumor stroma of cases of fibroadenoma and DCIS. The percentage of tumors that exhibited neurogenesis increased from tumor grade I to tumor grade II and III (29.4% vs 71.8%, p < 0.0001). In addition, patients with less than 3 years of disease-free survival tended to have a higher positive expression of PGP 9.5 compared to patients with an equal or more than 3 years of disease-free survival (64.8% vs 46.7%, p = 0.035). Furthermore, moderate/strong expression of PGP 9.5 was found to be significantly related to microvessel density (MVD, p = 0.014). Interestingly, PGP 9.5 expression was significantly associated with higher MVD in the ER-negative (p = 0.045) and node-negative (p = 0.039) subgroups of IDC of the breast.

Conclusions
This data indicates that neurogenesis is associated with some aggressive features of IDC including tumor grade and patient survival as well as angiogenesis, especially in ER-negative and node-negative subtypes of IDC of the breast. Thus, neurogenesis appears to be associated with breast cancer progression and may play a role in therapeutic guidance for patients with ER-negative and node-negative invasive breast cancer.
SOX2 and cancer: current research and its implications in the clinic
Authors: Weina Kasia , Utikal Jochen 
Published: July 2014

AbstractSOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and contains a high‐mobility group (HMG) domain, which permits highly specific DNA binding. Consequently, SOX2 functions as an activator or suppressor of gene transcription. SOX2 has been described as an essential embryonic stem cell gene and moreover, a necessary factor for induced cellular reprogramming. SOX2 research has only recently switched focus from embryogenesis and development to SOX2's function in disease. Particularly, the role of SOX2 in cancer pathogenesis has become of interest in the field. To date, studies have shown SOX2 to be amplified in various cancer types and affect cancer cell physiology via involvement in complicated cell signaling and protein‐protein interactions. Recent reviews in this field have highlighted SOX2 in mammalian physiology, development and pathology. In this review, we comprehensively compile what is known to date about SOX2's involvement in cancer biology, focusing on the most recent findings in the fields of cellular signaling and cancer stem cells. Lastly, we underscore the role of SOX2 in the clinic and highlight new findings, which may provide novel clinical applications for SOX2 as a prognostic marker, indicator of metastasis, biomarker or potential therapeutic target in some cancer types.
Gold Nanoparticles Modified with Artificial Siderophore–Iron(III) Ion Complexes: Selective Adsorption and Aggregation of Microbes Using “Coordination Programming”
Authors: Inomata Tomohiko , Murase Takanori , Ido Hiroki , Ozawa Tomohiro , Masuda Hideki 
Published: July 2014

Abstract
Artificial siderophore–Fe3+ complexes were prepared and modified with Au nanoparticles. These nanoparticles were found to selectively adsorb onto microbes and initiate selective aggregation. The aggregation of microbes leads to the amplification of the detection sensitivity when measured using siderophore-modified quartz crystal microbalance (QCM) sensors.
Synthesis and Properties of Poly(phenyleneethynylene)s Bearing Perylene Moieties at the Side Chains
Authors: Hashimoto Akinobu , Miyagi Yu , Sogawa Hiromitsu , Yamamoto Shunsuke , Sanda Fumio 
Published: July 2014

Abstract
The Sonogashira–Hagihara coupling polymerization of d-hydroxyphenylglycine-based diiodo monomers 1 and 2 with p-diethynylbenzene gave novel optically active poly(phenyleneethynylene)s 3 and 4 bearing perylene moieties with number-average molecular weights (Mn's) of 4800 and 3700 in 39% and 57% yields. The CD and UV–vis spectroscopic analysis revealed that polymer 3 formed folded helical structures in various solvents, while polymer 4 did not. UV–vis and fluorescence spectroscopic analysis indicated the presence of energy transfer from the phenyleneethynylene main chain to perylene side chains.
Validation of simplified predictive score for postoperative mortality after pancreaticoduodenectomy
Authors: Nugroho Adianto , Lalisang Toar J.M. 
Published: July 2014

Background: Pancreaticoduodenectomy has long been associated with high rates of morbidity and mortality. The key to a better postoperative outcome is a good patient selection. The aim of this study was to develop a simplified preoperative predictive score for postoperative mortality after pancreaticoduodenectomy.Methods: Patients who underwent elective pancreaticoduodenectomy from 1995 to 2012 were identified from the Division of Digestive Surgery database. Bivariate analysis and multivariate logistic regression analysis identified prediction of morbidity and mortality. ROC curve estimation is use to determined the cut-off value of the predictive score.Results: Of 138 patients who underwent pancreaticoduodenectomy, 27 patients (19.6%) died. The predictor of mortality are serum total bilirubin ≥ 10 mg/dL, serum creatinin ≥ 1.3 mg/dL, hematocrit ≤ 30%, serum albumin ≤ 3.0 g/dL and ASA status ≥ 3, with assign score 1, 1, 2, 1, 1, respectively. The cut-off value was 4 with 96% sensitivity and 91% specificity. The area under the receiver operator characteristic curve was 0.974 (SE 0.011; p < 0.001), which demonstrated a reasonable predictive value for the score.Conclusion: A total score of 4 or more is associated with increased postoperative mortality in patients underwent pancreaticoduodenectomy.
Relación TG/HDL-C y resistencia a la insulina en mujeres adultas argentinas según su estado nutricional
Authors: Belén Lorena , Oliva Maria Laura , Maffei Laura , Rossi Maria Laura , Squillace Celeste , Alorda Maria Beatriz , Torresani Maria Elena 
Published: July 2014

Introducción: la valoración del índice TG/HDL-C resulta un indicador del tamaño de las LDL, facilitando la detección de individuos con riesgo aterogénico aumentado. El objetivo del estudio fue estimar la asociación entre TG/HDL-C y resistencia a la insulina (RI) según el estado nutricional en mujeres adultas.Material y métodos: diseño descriptivo transversal, de mujeres adultas no embarazadas, y aparentemente sanas, mayores de 30 años de edad, concurrentes a la Fundación para Investigación de Enfermedades Endócrino Metabólicas e Investigación Clínica Aplicada (FIEEM) en la Ciudad Autónoma de Buenos Aires. Variable dependiente: relación TG/HDL-C considerando valor elevado ≥ 3,0. Variables independientes: RI por Índice modelo homeostático HOMA-IR ≥ 2,5 categorizando a la muestra en dos grupos: con y sin RI, y controladas según el estado nutricional mediante índice de masa corporal (IMC) y circunferencia de la cintura (CC). Estadística con SPSS 15,0, calculando X2 o prueba exacta de Fisher, OR con intervalos de confianza del 95% y regresión logística estableciendo valor p < 0,05.Resultados: se evaluó una muestra intencional de 104 mujeres (31,4% con RI y 26% con TG/HDL-C elevada). El 84,6% presentó sobrepeso u obesidad y el 88,5% CC aumentada. Las mujeres con IMC aumentado presentaron significativamente 0,15 veces (IC 95% = 0,01-1,26; p = 0,04) más riesgo de TG/HDL-C elevada que las mujeres normopeso. No hubo significación con la CC aumentada. La relación TG/HDL-C elevada se correlacionó significativamente con RI (r = 0,30 p= 0,002).Conclusiones: el peso corporal se asoció significativamente con RI y la relación TG/HDL-C aumentada. Esta relación se correlacionó con la RI en mujeres aparentemente sanas.
VuFind als Discovery-Tool für digitalisierte Kulturgüter
Authors: Mutschler Thomas 
Published: July 2014

Zusammenfassung
Im digitalen Zeitalter erschöpft sich das Aufgabenspektrum der Archive, Bibliotheken und Museen längst nicht mehr in der Sammlung, Erschließung, Bewahrung und Zugänglichmachung physischer Sammlungsbestände. Es bezieht die Digitalisierung ebenso mit ein wie die Zusammenführung der Digitalisate in übergreifenden Internetportalen. Der folgende Beitrag bietet einen Überblick zum Einsatz der Open-Source-Software VuFind, welche als Discovery-Tool für digitalisierte Kulturgüter vorgestellt wird. Erläutert werden nicht nur die Anforderungen, die sich für die Erschließung und das Metadatenmanagement ergeben, sondern auch die Chancen einer engeren Kooperation von Archiven, Bibliotheken und Museen im digitalen Zeitalter. Abgerundet wird der Beitrag um Ausführungen zum Portal digitales thüringen, welches die Anwendung VuFind-basierter Discovery-Technologie im Kontext der Digitalisierung von Kulturgut beispielhaft illustriert.
Singular limits solution for 2-dimensional elliptic problems involving
exponential nonlinearities with sub-quadratic convection nonlinear
gradient terms and singular weights
Authors: Baraket Sami , Ouni Taieb 
Published: July 2014

Abstract
Given a bounded open regular set Ω of

ℝ
2

$\mathbb {R}^2$

,

q
1

,
...
,

q
K

∈

Ω

${q_1, \ldots , q_K \hspace*{-0.85358pt}\in \hspace*{-0.85358pt} \Omega }$

, a regular
bounded function

ϱ

:

Ω

→

[
0
,
+
∞
)

${\varrho \hspace*{-0.56905pt}:\hspace*{-0.56905pt} \Omega \hspace*{-0.85358pt}\rightarrow \hspace*{-0.85358pt} [0,+\infty )}$

and a bounded function

V
:
Ω
→
[
0
,
+
∞
)

${V: \Omega \rightarrow [0,+\infty )}$

, we give a sufficient
condition for the model problem

-
Δ
u
-
λ
ϱ

(
x
)

|
∇
u
|

q

=

ε
2

V

(
x
)

e
u

$
-\Delta u -\lambda \varrho (x)\vert \nabla u\vert ^q = \varepsilon ^2 V(x) e^u
$

to have a positive weak solution in Ω with u = 0 on

∂
Ω

${\partial \Omega }$

, which is singular at each qi
as the parameters ε and λ tend to 0, without considering any relation between them, essentially when the set of concentration points qi
and the set of zeros of V are not necessarily disjoint and

q
∈
[
1
,
2
)

$q\in [1,2)$

is a real number.
Was hat Max Weber mit Kātib Čelebi zu tun? Ein Annäherungsversuch an Gottfried Hagen
Authors: Zemmin Florian 
Published: July 2014

Abstract
This article responds to Gottfried Hagen's extensive review (see Der Islam 2/2013) of my book Islamische Verantwortungsethik im 17. Jahrhundert. Ein weberianisches Verständnis der Handlungsvorstellungen Kātib Čelebis (1609–1657). Whilst I benefitted greatly from some of Hagen's critical remarks and historical elucidations, his review not only misstates crucial passages of my book but also largely disregards its main objective, which is to develop a systematic model for understanding Kātib Čelebi's ethical stance. Besides reiterating crucial arguments ignored and rectifying central aspects misrepresented in Hagen's review, I here ask how the more fundamental misunderstandings – exceeding differences in theoretical positions or empirical observations – between the au-thor's intentions and the reviewer's reception may be explained. Gottfried Hagen's historiographical perspective on Kātib Čelebi diverges from my sociological take on the same subject matter to the extent that both perspectives are struggling to enter into dialogue. Such dialogue, however, remains highly desirable so as to complement a historical reconstruction of Kātib Čelebi's life and times with a systematic, theoretically grounded understanding of his views.
A Note on the Multi-stage Spectral Relaxation Method for Chaos Control and Synchronization
Authors: Dlamini Phumlani Goodwill , Khumalo Melusi , Motsa Sandile Sydney 
Published: July 2014

Abstract
In this study, we present and apply a new, accurate and easy to implement numerical method to realize and verify the synchronization between two identical chaotic Lorenz, Genesio-Tesi, Rössler, Chen and Rikitake systems. The proposed method is called the multi-stage spectral relaxation method (MSRM). We utilize the active control technique for the synchronization of these systems. To illustrate the effectiveness of the method, simulation results are presented and compared with results obtained using the Runge-Kutta (4, 5) based MATLAB solver, ode45.
Military Spending and Economic Growth in An Augmented Solow Model: A Panel Data Investigation for OECD Countries
Authors: Hou Na , Chen Bo 
Published: July 2014

AbstractThe defence-growth nexus has been investigated by many studies and has always been a controversial area of research. By applying an Augmented Solow Growth Model integrated with a military burden variable, this paper examines the effect of military expenditure on economic growth for 21 OECD countries during the period 1960–2009. Different panel estimation methodologies are used to analyze the economic effects of military expenditure. The empirical results suggest that military expenditure would appear to have a negative effect on growth.
TORC2—a new player in genome stability
Authors: Weisman Ronit , Cohen Adiel , Gasser Susan M 
Published: July 2014

AbstractThe inhibition of the central growth regulatory kinase TOR, which participates in two complexes, TORC1 and TORC2, has been a focus of metabolic and cancer studies for many years. Most studies have dealt with TORC1, the canonical target of rapamycin, and the role of this complex in autophagy, protein synthesis, and cell growth control. Recent work on TORC2 in budding and fission yeast species points to a conserved role of this lesser‐known TOR complex in the survival of DNA damage. In budding yeast, TORC2 controls lipid biosynthesis and actin cytoskeleton through downstream AGC kinases, which are now, surprisingly, implicated in the survival of oxidative DNA damage. Preliminary data from mTORC2 modulation in cancer cells suggest that an extension to human chemotherapy is worth exploring.