bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and Acceptability of an Online Daily Exercise Program for Community-Dwelling Older Adults: A Randomized Controlled Trial
Authors: Machacova Katerina , Steffl Michal , Bartova Alzbeta , Novotná Blanka , Holmerova Iva 
Published: July 2024

Abstract

Background: We all know how important it is to stay physically active, especially in later life. However, the majority of the population, including older adults, remains sedentary and lacks regular physical activity. The aim of this study was to assess the feasibility and acceptability of a home-based online education and exercise program inspired by developmental kinesiology that was designed for daily use to support functional capacity and an active lifestyle.
Methods: Eighty-two community-dwelling older adults (mean ± SD age 73.7 ± 3.4, 77% female) were randomized into intervention (n = 45) and control (n = 37) groups. Participants in the intervention group followed a 12-week home-based exercise program of 15 minutes per day for at least 6 days a week. Adherence was assessed using a diary, and acceptability was assessed using a postintervention questionnaire. Functional status was examined by performance tests (Timed Up and Go Test, Single Leg Stance Test, and Hand Grip) and a single-item question ("How would you rate your functional status from excellent to poor?") at baseline and postintervention. The data were analysed in SPSS using descriptive statistics, t tests, chi-square tests, and ANOVA.
Results: The intervention was feasible and acceptable. The retention rate in the experimental group was 100%, and the adherence rate was 99.9%. The program was rated on a 5-point Likert scale as clear (87% considered the program excellent), meaningful (80%), or manageable (71%). All participants (100%) in the experimental group would recommend the program to peers, and 91% expressed a willingness to continue. Additionally, participants felt more fit postintervention (T = 4.96, p < .001; F = 4.83, p < .05) and demonstrated improved one-leg stability (T = -3.45, p = .001). The improvement in agility was not statistically significant but was slightly clinically significant (ES = .05), and grip strength was not affected by the intervention.
Conclusions: We conclude that the designed program has great potential to become a welcome part of everyday life among older adults, providing many benefits for this population. It is evident that older generations can follow online exercise programs and improve their health habits in the long term.
Trial Registration: The trial was retrospectively registered at ClinicalTrials.gov (NCT06133894).
Funding: This research was funded by #NU22-09-00447: 2022-2025.
Hydrodynamics and sediment transport in normal weather: examples from a macrotidal tidal flat-channel system, Rudong, Jiangsu
Authors: Liu Zhenqiao , Xue Liming , Gao Chao , Shi Benwei , Wang Ya Ping , Gao Shu 
Published: July 2024

Abstract

A detailed understanding of the hydrodynamics and sediment transport mechanisms of the intertidal mudflat-channel system can better predict its future survival and development potential. This study selected a typical open-coast macrotidal mudflat, Xiaoyangkou tidal flat in Rudong in the central part of Jiangsu Province, as the studied area, with field observations conducted on the tidal mudflat-channel system during tidal cycles. The study revealed wind waves generated by winds of around 7 m/s within a fetch length of 5 km can cause significant erosion on the mudflats during neap tides. Wind waves cannot cause erosion on the thalweg within the tidal channels and the lower parts of the banks under normal weather conditions. The peak flow velocity in the flood and ebb within the tidal channels occurs below the bankfull depth. Three different types of erosion processes were observed on the channel slopes: (1) Small-scale erosion on slopes of less than 10 cm in width and less than 5 cm in depth, causing widening and deepening of small tidal gullies, leading to vertical erosion of the slopes. (2) Medium-sized tidal creeks with 10–100 cm widths and depths of 5-100 cm experiencing sliding erosion. (3) Large tidal channels with widths greater than 200 cm and depths greater than 100 cm are more likely to toppling collapse. Continuous waves caused by wind oscillations below the bankfull depth at the observed cross-section of the tidal channels may be the main cause of erosion on the channel banks.
Development and validation of a risk prediction model for social isolation in older adults
Authors: Li Ya-Qin , Long Ying-Yin , Huang YuTing , Wang Yu 
Published: July 2024

Abstract

Background: Older people are at high risk of social isolation (SI), which can have adverse effects on their health. The extent of SI amongst older people has emerged as a major concern for health and social policy. The objective of this study was to develop a risk prediction model for SI in older adults.
Methods:A total of 4817 participants aged 60 and over were selected from the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Participants were randomly assigned to the training set and the validation set at a ratio of 70 to 30%. LASSO regression analysis was used to screen the predictors. Then, identified predictors were included in multivariate logistic regression analysis and used to construct model nomogram. The performance of the model was evaluated by area under the receiver operating characteristic (ROC) curve (AUC), calibration curves and decision curve analysis (DCA).
Results: Out of 4817 participants, 1175 were in a state of SI. Multivariate logistic regression analysis showed that gender, age, living arrangements, ADL, cognitive function, exercise, medical insurance, community services, intergenerational economic support and homeownership were predictors of SI in older adults. Using these factors, a nomogram model was constructed. The AUC values for the training and validation sets of the predictive model were 0.861 (95% CI= 0.846-0.875) and 0.864 (95% CI= 0.843-0.886), respectively. Calibration curves demonstrated that the predicted values of the nomogram were in good agreement with the observed data. DCA showed that the model had good clinical validity.
Conclusion: The nomogram constructed in this study is a useful tool for evaluating the SI risk of elderly individuals, which can help community healthcare workers identify high-risk individuals. The variables used in the model are easy to obtain, and the performance of the model is good, making it easy to use and promote in the community.
Evaluation of Autonomic Nervous System Status with Sympathetic Skin Response in Patients Undergoing Laparoscopic Sleeve Gastrectomy for Morbid Obesity
Authors: Elkan Hasan , Ağırcan Dilek , Yüksekyayla Baran , Erdoğdu Hamza 
Published: July 2024

Abstract

Introduction and Purpose: Obesity is the most common metabolic disease of our time. Bariatric surgery is now accepted as the definitive treatment for morbidly obese patients. The most commonly performed bariatric surgery method is “Laparoscopic Sleeve Gastrectomy (LSG)”. Patients often report various complaints related to the autonomic nervous system after obesity surgery. Sympathetic Skin Response (SSR) is a simple and non-invasive test used for the early diagnosis of dysautonomia in peripheral neuropathy, demonstrating the function of postganglionic unmyelinated sympathetic sudomotor fibers by using changes in skin resistance. This study aims to evaluate the autonomic nervous system status in patients undergoing LSG for morbid obesity using Sympathetic Skin Response (SSR).
Method: The study was conducted prospectively with 40 volunteer patients who applied to Harran University Hospital General Surgery Department, had a BMI over 40, and underwent obesity surgery. Patients were neurologically evaluated in the preoperative period. The patients deemed suitable in the evaluation had their SSR recorded with tests conducted by the Neurology Department. The same group of patients had their sympathetic skin responses evaluated and recorded 6 months postoperatively, and statistical analyses were conducted.
Findings: The decrease in BMI and SSR latency values before surgery compared to after surgery (p<0.001; p<0.001, respectively) and the increase in SSR amplitude values were found to be statistically significant (p<0.001).
Discussion and Conclusion: Our study detected a significant increase in sympathetic skin response post-surgery. Hormonal changes such as the improvement of insulin resistance and the decrease in leptin levels, as well as the stressful nature of the surgical process, might lead to an increase in sympathetic nervous system activity. We believe that performing the low-cost and simple SSR test in patients undergoing obesity surgery could be important for the follow-up of potential neuropathies in the future.
Establishing a Certificate in the Analysis of Medical Data: A Cross-Sectional Evaluation of a Continuing Professional Development Course in Biostatistics in for healthcare professionals in Qatar
Authors: Ali Saima , Al-Sheikhly Deema , Mattar Laudy , Navti Phyllis , Dargham Soha , Healy Mark , Mahfoud Ziyad 
Published: July 2024

Abstract

Background: Healthcare professionals often face challenges in conducting and publishing research, citing a lack of biostatistical knowledge and skills as a significant barrier. In response, a Continuing Professional Development (CPD) course was developed to enhance local research capacity.
Objective: This paper aims to delineate the establishment and delivery of the biostatistics course for healthcare professionals, while presenting evaluation findings focused on self-reported enhancements in knowledge, competence, and performance. Additionally, potential areas for course refinement are explored.
Method: A cross-sectional descriptive analysis was conducted, utilizing routine data from evaluations aligned with accreditation standards. Data included attendance records, certificate completions, and findings from two self-report surveys administered post-course. The surveys gauged changes in knowledge and competence, achievement of course objectives, barriers to certificate completion, and long-term outcomes such as research publication.
Results: Findings indicated widespread consensus on meeting course objectives, albeit with challenges noted in certain intermediate and advanced topics. Participants reported notable improvements in knowledge, competence, and performance, underscoring the course's efficacy. Long-term assessment revealed sustained biostatistical skills, with a majority crediting the course for manuscript drafting (over 50%) and publication support (42%).
Conclusion: The CPD course in biostatistics yields positive outcomes in knowledge, competence, and performance among healthcare professionals. Identified challenges in advanced topics and certificate completion warrant improvements such as extending course duration, integrating cost-effective online platforms, and offering enduring material for comprehensive review. Rigorous research methodology is crucial for exploring causal relationships and enhancing the effectiveness of research capacity-building initiatives in the region.
The“Overlapping”Lymphaticovenous Anastomosis: an overlapped end-to-end anastomosis Supermicrosurgical Technique
Authors: Wang Cheng , Li Bowen , Zhong Zhumao , tao Weiye , zheng Youmao , Liang Junbo , Liu Chong 
Published: July 2024

Abstract

Objective
Lymphaticovenular anastomosis has become an increasingly common treatment for lymphedema. Supermicrosurgical techniques are essential for the successful performance of lymphaticovenular anastomosis, one of the most common hurdles faced by lymphatic surgeons while carrying out a LVA is a mismatch in sizes of the vein and the lymphatic vessels. This study aims to evaluate the effectiveness and safety of the "Overlapping" lymphaticovenular anastomosis technique, which involves overlapping the lymphatic and venous vessels to achieve size mismatch anastomosis.
Methods
The seventeen patients with lymphedema were included in the study, and three types of anastomosis were performed, including Overlapping, end-to-end and octopus anastomosis. The Overlapping technique involves traction of the lymphatic vessels into the venous vessels so that the lymphatic vessels overlap with the venous vessels to complete the anastomosis. Time anastomosis, method anastomosis, and patency rates, and lymphedematous volume was evaluated in this study.
Results
A total of 17 patients were treated over the course of this study. The overall success rate was 100% as measured by clinical observation (lymphatic reflux) and intraoperative ICG lymphography. The mean time of Overlapping anastomosis was 6.3 minutes. The mean amount of drainage was 472.29 ml (324.8-612.0ml ), and only one patient had poor ICG drainage after the procedure, but it improved after resuturing. It was found that the cuff anastomosis significantly reduced the operative time compared to the other two anastomotic techniques, and all patients showed significant improvement in postoperative limb edema.
Conclusions
The Overlapping technique could serve as a valuable addition to the current LVA technique. This technique has the potential to promote the broader application of LVA in the treatment and prevention of lymphedema.
Comparison of Left Ventricular Function after His Bundle Pacing vs Left Bundle Branch Area Pacing Implantation
Authors: Prakoso Kurniawan , Wibawa Kevin , Karwiky Giky , Akbar Mohammad Rizki , Martha Januar Wibawa , Iqbal Mohammad 
Published: July 2024

Abstract

Background
Right ventricular pacing may lead to deterioration of left ventricular (LV) function. Recent guideline suggests the use of conduction system pacing (CSP) with either his bundle pacing (HBP) or left bundle branch area pacing (LBBAP). This study aimed to investigate the difference of LV function between HBP and LBBAP.
Methods
This is a prospective cohort study enrolling patients age > 18 years requiring CSP implantation from June 2020 to January 2024 in Hasan Sadikin General Hospital, Bandung. Data regarding QRS duration and several echocardiography parameters were obtained at baseline and during follow up within 1 year after CSP implantation.
Results
From 66 patients, 35 were included in the HBP group. There was no difference in QRS duration at baseline between both groups with higher left ventricular ejection fraction (LVEF) in HBP group (51.17 ± 13.87% vs 45.58 ± 11.08%, p = 0.078). During follow up, HBP group showed narrower QRS duration (113.40 ± 17.06ms vs 120.81 ± 12.12ms, p = 0.029). LV function was preserved in HBP group while there was a trend of LV function improvement in LBBAP group (53.11 ± 11.67% in LBBAP vs 53.93 ± 11.45% in HBP group, p = 0.536). Further analysis in 33 patients with LV dysfunction showed a trend of LVEF improvement in both groups (35.31 ± 7.86% to 44.54 ± 11.28% in HBP and 38.75 ± 6.95% to 51.35 ± 13.14% in LBBAP group).
Conclusion
HBP resulted in narrower QRS complex. However, both HBP and LBBAP showed a trend of LV function improvement in patients with LV dysfunction.
Viral load in febrile phase rather than the duration of virus associates the severity of hemorrhagic fever with renal syndrome
Authors: Shi Lei , Wang Shipu , Wang Fenglan , Zhang Xi , Zheng Jie , Ren Danfeng , Tang Tiantian , Li Hongbin , Li Yanping , Wang Yawen , Hu Jinsong , He Yingli , Lin Shumei , Liu Zhengwen , Zhao Yingren , Chen Tianyan 
Published: July 2024

Abstract

Hemorrhagic fever with renal syndrome (HFRS) was Hantaviruses infectious disease with a mortality rate of 1-10%. In the previous studies, the duration of the virus and the relationship between the virus and the severity of the disease were still unclear. 137 patients with HFRS were enrolled in this study, patients were followed up every three days until the virus load was negative. Virus quantification was performed using RT-PCR method. Of all the 137 patients, 38 patients (28%) were classified as severe/critical cases. We found that the duration of the virus lasted much longer than we thought before. Most patients still have virus during the polyuria phase, and some patients even have virus in recovery phase. We confirmed that viral load in febrile phase rather than the duration of virus associated with the severity of Hantaan virus caused HFRS. This indicates that tissue damage in HFRS may not related to the virus, virus activated immune response in the early stages may responsible for the pathogenesis. Understanding the mechanism of virus in HFRS will provide ideas and guidance for better clinical treatment.
ONC201 Exerts Oncogenic Effects Beyond its Mitochondria-Disturbing Role in Neuroblastoma Subsets
Authors: Jiang Jyun-Hong , Lin Yu-Han , Liao Pei-Lin , Chen Ting-Ya , Chuang Hui-Ching , Huang Chao-Cheng , Hsu Wen-Ming , Chuang Jiin-Haur , Wei-Shiung Lian 
Published: July 2024

Abstract

Neuroblastoma (NB) is a formidable challenge in pediatric oncology due to its intricate molecular landscape, necessitating multifaceted therapeutic approaches. ONC201 is an imipridone antibiotic compound with a promising drug candidate leveraging its potent anticancer properties against the mitochondrial proteases ClpP and ClpX. Despite demonstrating early clinical promise, particularly in MYCN-amplified NB, its efficacy in non-MYCN-amplified NB remains a subject worthy of investigation. In this study, we extend the coverage of ONC201 to treat non-MYCN-amplified neuroblastoma, and our data implicated ONC201's inability to reduce tumor growth in animal models harboring SK-N-AS or SK-N-FI cell lines. Interestingly, ONC201 induced the expression of oncogenic markers c-Myc and LGR5 while downregulating the tumor suppressor ATRX. While it fails to attenuate tumor neovascularization in non-MYCN-amplified NB xenografts, its effectiveness differs from that of its MYCN-amplified counterpart. Rho zero (ρ0)-SK-N-AS cells treated with ONC201 showed comparable observed trends in parental SK-N-AS cells, including LGR5 upregulation and ATRX downregulation, suggesting that ONC201's multifaceted actions extend beyond mitochondrial targets. Our elucidation highlights the need to discern molecular signatures when deploying ONC201 monotherapy against NB, which lacks MYCN-amplification.
To develop a prediction model for cardiotoxicity induced by anthracyclines combined with chemotherapy
Authors: Pengxiang Zhang , Yan Zhang , Bing Duan , Jie Mi 
Published: July 2024

Abstract

Purpose:
Anthracyclines are commonly used as curative agents in chemotherapy for patients with breast cancer and lymphoma. Although the chemotherapeutic effect of anthracyclines is good, the cardiotoxicity caused by these drugs cannot be ignored. In this study, we included using anthracycline-based drugs in combination with chemotherapy in patients with breast Cancer and lymphoma, study its after Cancer chemotherapy related heart toxicity (Cancer therapy - related cardiac dysfunction, CTRCD) of the independent risk factors. LASSO regression analysis was used to screen predictive factors to construct a clinical prediction model (nomogram), and the identification accuracy and clinical efficacy of nomogram were verified to provide a theoretical basis for predicting CTRCD in such patients.
Methods:
1. Eligible patients were randomly assigned to the training and validation cohorts in a 5:1 ratio according to specified inclusion and exclusion criteria. With CTRCD as the primary endpoint, univariate and multivariate logistic regression analysis was performed on the training cohort to determine the independent prognostic factors of CTRCD. 2. Use LASSO regression to select predictors and develop a nomogram. Then, the calibration Curve, Hosmer-Lemeshow (H-L) goodness-of-fit test, Receiver Operating Characteristic (ROC) curve and Decisive Curve Analysis were used to analyze the nomogram. DCA was used to evaluate the performance of the nomogram. Internal validation was performed to check the stability of the model.
Results:
1. A total of 324 patients were included in this study. logistic multivariate regression analysis of the training cohort showed that Body Mass Index (BMI) ≥ 25, previous history of diabetes, Brain Natriuretic Peptide (BNP) ≥ 52pg/ml, pathological stage, low density lipoprotein (LDL) ≥ 3.37mmol/L, and cumulative dose of anthracyclines ≥ 550mg/㎡ were statistically significant (P < 0.005). 2. The C-index of the prediction model was 0.872 (95%CI:0.821–0.923) and 0.886 (95%CI:0.799–0.974), and the p value of H-L test was 0.837 and 0.700 in the training and validation cohorts, respectively.
Conclusion:
1. BMI ≥ 25, history of diabetes, BNP ≥ 52pg/ml, LDL ≥ 3.37mmol/L, pathological stage, cumulative dose of anthracyclines ≥ 550mg/㎡ are independent risk factors for CTRCD in breast cancer and lymphoma patients receiving anthracyclines combined chemotherapy.2. The prediction model has good discrimination, and can preliminarily predict the risk of cardiotoxicity in patients with lymphoma and breast cancer using anthracycline-based chemotherapy. This model has certain reference value for the prediction of cardiotoxicity in other chemotherapy regimens using anthracyclines.
Traditional Bone Setting in Nigeria from the Perspectives of Patients and Physiotherapists— Clinical Insights for Low Back Pain Management
Authors: Adje Mishael , Karstens Sven , Mbada Chidozie , Steinhäuser Jost 
Published: July 2024

Abstract

Background:Traditional bone setting (TBS) remains a prevalent healthcare practice in Nigeria, offering alternative treatments for musculoskeletal conditions such as low back pain (LBP). This study explores the perspectives of both patients and physiotherapists regarding TBS and its implications for the management of LBP.Methods:A qualitative research approach was employed, utilizing semi-structured interviews with 25 participants (12 patients who had utilised TBS services for LBP, and 13 physiotherapists). Theoretical sampling was employed in participant recruitment until saturation. Recordings were transcribed and thematic analysis was done as a secondary analysis. Reporting was informed by the Consolidated Criteria for Reporting Qualitative Research (COREQ).Results:Eleven (11) participants were female and 14 were male; with a mean age of 35 years. Five themes emerged from this study themes: driving impetus for TBS, influencing perceptions with information, turning to TBS as a final recourse, exploring the primary alternative, and integrating TBS. Shift towards TBS for LBP stems from deficiencies in prevailing healthcare practices in Nigeria. Patients and physiotherapists hold varying perspectives regarding cultural significance, and effectiveness and safety of TBS compared to conventional physiotherapy interventions. Accessibility, affordability, and perceived efficacy are common facilitators for the patronage of TBS among patients, while others were hesitant and viewed it as a last resort. Negative perception of physiotherapists about TBS for LBP were based on concerns regarding the lack of scientific evidence, standardized practices, and potential complications associated with the procedures.Conclusion:Participants view TBS as a viable alternative when conventional treatments fail, driven by expectations for therapist-guided techniques, physiotherapist shortage, combined with affordability and cultural factors. Physiotherapists remain cautious, citing a need for evidence-based interventions and noting the extreme complications sometimes seen from TBS. Despite differing views, some participants advocate for an inclusive healthcare approach that integrates TBS with conventional medicine, emphasizing collaboration and better communication between healthcare providers and TBS practitioners. Future research could examine formal training programs to integrate Traditional Bone Setting (TBS) with conventional medical practices.