bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sneddon's Syndrome and Antithrombin III
Authors: Bolayir Ertugrul , Keçeci Hulusi , Akyol Melih , Taş Ayşenur , Polat Murat 
Published: April 2015

AbstractSneddon's syndrome, an uncommon disorder, is characterized by multiple cerebrovascular accidents along with ideopathic livedo reticularis. In this article, two cases who had increased amounts of antithrombin III and were diagnosed with Sneddon's syndrome are presented.
Twice Weekly 5 mg Dexamethasone Oral Pulse in the Treatment of Extensive Alopecia Areata
Authors: Sharma Vinod Kumar , Gupta Somesh 
Published: April 2015

AbstractThirty patients (20 males, 10 females) with widespread alopecia areata (25 extensive alopecia areata, 5 alopecia areata) for a mean period of 4.2 years were included in the study. All patients above 12 years were administered 5 mg dexamethasone oral pulse on two consecutive days every week. Three children (<12 years) received 2.5 mg to 3.5 mg dexamethasone oral biweekly pulse. Patients who had received treatment for a minimum period of 12 weeks were evaluated for terminal hair growth. Complete to excellent (75–95%) hair growth was observed in 16 (63.3%) patients. Growth was good (50–74%) in 2 cases and poor (<50%) in 3 (10%) cases. Six (20%) patients has no growth of terminal hair. Complete to excellent growth of hair was obtained after a mean period of 5.35 months (range 3–10 months). Relapse occurred in one case each after three and six months but hair regrew with re‐treatment.Side effects of corticosteriods were frequent, seen in 8 (26.6%) patients, but were mild. In only one case, treatment had to be discontinued. We propose that twice weekly 5 mg dexamethasone oral pulse for six months may be considered as one of the modalities in the treatment of extensive long standing alopecia areata.
Mast Cell “Densities” in Vascular Proliferations: A Preliminary Study of Pyogenic Granuloma, Portwine Stain, Cavernous Hemangioma, Cherry Angioma, Kaposi's Sarcoma, and Malignant Hemangioendothelioma
Authors: Hagiwara Keisuke , Khaskhely Noor Mohammad , Uezato Hiroshi , Nonaka Shigeo 
Published: April 2015

AbstractThe “densities” of mast cells (MCs) in six kinds of vascular proliferation, pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma (MHE), measured per mm2 were studied using respective specimens prepared with tryptase stain and a personal computer. The average densities of MCs in pyogenic granuloma and MHE were 103.5 ± 25.2/mm2 (n=10) and 106.3 ± 40.2/mm2 (n=10) [mean ± standard deviation (SD)]; that in normal skin was 6.85 ± 4.9/mm2 (n=20) (mean ± SD). is a significant difference [t‐test (p<0.0001) and Wilcoxon‐test (p<0.01)]. The results in portwine stain (n=4), cavernous hemangioma (n=9), cherry angioma (n=4), and Kaposi's sarcoma (n=4) were 68.6 ± 28.9/mm2, 105.7 ± 56.9/mm2, 85.3 ± 45.6/mm2, 82.2 ± 28.4/mm2 (mean ± SD), respectively, all of which were greater than that in normal skin by a simple comparison. The results of immunofluorescence microscopy were positive with basic fibroblast growth factor staining in the tissues of pyogenic granuloma, Kaposi's sarcoma and MHE. These facts may morphologically indicate a role of MCs in the angiogenesis of these vascular tumors.
Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus
Authors: Kawaguchi Hiroshi , Takeuchi Mizue , Ono Hideki , Nakajima Hiroshi 
Published: April 2015

AbstractAdult onset of inflammatory linear verrucous epidermal nevus (ILVEN) is reported in a 44‐year‐old Japanese man. A mild pruritic eruption appeared one year earlier and extended from the left dorsal foot to the gluteal region. Histologically, acanthosis and papillomatous thickening of epidermis as well as spongiotic edema and exocytosis with lymphocytes and neutrophils were observed. Topical tacalcitol was not effective, but the pruritus as well as the eruption slightly improved with topical corticosteroid and vaseline containing salicylic acid. This adult onset of ILVEN is considered to be a rare case.
Panniculitis Showing Membranocystic Changes in the Dermatomyositis
Authors: Lee Mi‐Woo , Lim Yeon‐Soon , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: April 2015

AbstractClinically obvious panniculitis in association with dermatomyositis is rare. We reported a patient with panniculitis showing membranocystic changes in the dermatomyositis.
Alopecia Areata, Stress and Psychiatric Disorders: A Review
Authors: García‐Hernández María José , Ruiz‐Doblado Sergio , Rodriguez‐Pichardo Antonio , Camacho Francisco 
Published: April 2015

AbstractAlthough the results of some studies have proven negative, the influence of psychological factors in the development, evolution and therapeutic management of alopecia areata is, in general, well documented. Life events and intrapsychically generated stress can play an important role in triggering of some episodes. The comorbidity of psychiatric disorders, mainly generalized anxiety disorder, depression, and phobic states, is high. The role of treatment of concomitant psychopathological disorders is a vital one. Indeed this treatment can positively affect how the patient adapts to his/her alopecia and social setting and perhaps can even lead to a better dermatological evolution of the alopecia. Therefore, controlled studies analyzing the possible links between psychiatric symptoms, treatment with antidepressants or benzodiacepines, evolution of alopecia, medium term prognosis, and immune function are necessary. Basic psychotherapeutic support may prove to be of use in many cases and can be carried out by the dermatologist, although a subgroup of patients may need psychopharmacological or psychotherapeutic specialized treatments. Studies using operative diagnostic criteria and structured interviews are still scarce. Therefore, it seems necessary to design studies using modern psychiatric methodology. Controlled clinical trials to test the efficiency of psychoactive drugs and psychotherapy in the disease are also needed. By studying in depth these and other related aspects, we may improve the clinical management of our patients.
Characterization of Early and Late Onset Psoriasis in the Korean Population
Authors: Youn Jai Il , Park Byung‐Soon , Park Seok‐Beom , Kim Sang‐Duck , Suh Dae‐Hun 
Published: April 2015

AbstractIt has been proposed that two types of psoriasis can be characterized based upon age of onset. The purpose of our study was to investigate the characteristics of early and late onset psoriasis in the Korean population. A total of 986 psoriasis patients were included in this study, and the age of onset frequency proved to be bimodal. Family history in the first‐degree relatives was significantly higher in the early onset group (<40 years old) when compared with the late onset group (≥40 years old). A series of statistical analyses concerning the correlation between the extent of involvement and age of onset showed that earlier onset is related to more extensive involvement. A questionnaire survey concerning the influence of various external factors upon their psoriasis was given to a subgroup of 800 psoriasis patients. Multiple logistic regression analysis, controlled for confounding factors such as current age, sex and extent of involvement, revealed that early onset psoriasis patients showed significantly increased tendencies to worsen at times of psychological stress and in winter, and to improve in summer, compared with late onset psoriasis patients. In conclusion, distribution of the age of onset revealed two peaks in Korean psoriasis patients, and psoriasis with an onset prior to the age of 40 years was associated with increased inheritability, greater susceptibility to seasonal changes and more psychological stress than psoriasis with later onset.
A Case of Acquired Autoimmune Bullous Disease Associated with IgM Macroglobulinaemia
Authors: Morita Eishin , Horiuchi Kenji , Yamamoto Shoso , Hashimoto Takashi 
Published: April 2015

AbstractA variety of autoimmune bullous dermatoses have been reported to develop in association with lymphoproliferative disorders. We report a patient with IgM macroglobulinaemia, who presented with a skin fragility similar to but somewhat milder than that seen in epidermolysis bullosa acquisita. Immunofluorescence detected circulating IgM autoantibodies reacting with the basement membrane zone, which reacted predominantly with dermal side of 1 M NaCl‐split skin. Immunoblotting of the epidermal and dermal extracts with the patient's serum showed no specific reactivity. Further studies are needed to identify the antigenic molecules responsible for the IgM deposition.
A Case of Pachyonychia Congenita with Oral Leukoplakia and Steatocystoma Multiplex
Authors: Lim Tuk‐Woo , Paik Jong‐Hyun , Kim Nack‐In 
Published: April 2015

AbstractPachyonychia congenita (PC) is an uncommon autosomal dominant genodermatosis affecting the nails and other ectodermal tissues. The most striking features are symmetrically thickened dysmorphic nails and hyperkeratotic skin lesions.We report a case of pachyonychia congenita in a 30‐year‐old male patient who had thickening and gray‐brown discoloration of all nails and many nodules on his back and neck. He also had hyperkeratotic skin lesions on both feet. His tongue had irregularly‐shaped, whitish plaques. Histology of these nodules revealed the characteristic features of steatocystoma multiplex. After treatment with oral retinoic acid, his hyperkeratotic skin lesions improved.
A Case of Werner's Syndrome Associated with Osteosarcoma
Authors: Murata Kaoru , Hatamochi Atsushi , Shinkai Hiroshi , Ishikawa Yuichi , Kawaguchi Noriyoshi , Goto Makoto 
Published: April 2015

AbstractWe described a case of Werner's syndrome associated with osteosarcoma. A 37‐year‐old Japanese man was diagnosed as having Werner's syndrome by the presence of juvenile cataracts, skin sclerosis and hyperpigmentation of the feet, high‐pitched voice, characteristic bird‐like appearance of the face with beak‐shaped nose, thinning of the entire skin and hyperkeratoses on soles, hyperlipemia, hyperuricemia, diabetes melitus, and the mutated responsible gene (WRN). He had a 3‐month history of a tumor on his left forearm. Histologically, the tumor included four histological patterns; a malignant fibrous histiocytoma‐like, a desmoid‐like, a dermatofibrosarcoma protuberans‐like, and a chondrosarcoma‐like pattern. Tumoral osteoid formation was also found in the tumor. Therefore, the tumor was diagnosed as osteosarcoma.
Colchicine Therapy for Low‐Dose‐Methotrexate‐Induced Accelerated Nodulosis in a Rheumatoid Arthritis Patient
Authors: Abraham Zeev , Rozenbaum Michael , Rosner Itzhak 
Published: April 2015

AbstractAccelerated nodulosis developed on the fingers of a woman successfully treated with low dose methotrexate for rheumatoid arthritis. Colchicine therapy resulted in regression of these nodules for twelve months. To our knowledge, this is the first report in the dermatological literature on this relatively new entity in which the skin is also involved.
Bowen's Diseases and Basal Cell Carcinomas in a Patient
Authors: Kim Hee Joong , Min Hyung Geun , Lee Eil Soo 
Published: April 2015

AbstractBowen's disease is a well‐known precancerous lesion, in which invasive squamous carcinoma may develop. However, it is rare that Bowen's disease, basal cell carcinoma, and internal malignancy develop in a single patient.We report a case of a 54‐year‐old male patient with Bowen's disease, basal cell carcinoma of the skin, and squamous cell carcinoma of the lung. Multiple scaly erythematous patches had developed several years earlier and were diagnosed as Bowen's disease by skin biopsy. The number of lesions increased and, five months ago, a right lower lobectomy was done for squamous cell carcinoma which was detected on a chest X‐ray. Skin biopsies of two different sites revealed Bowen's disease and basal cell carcinoma. The arsenic level was increased in his hair specimen. Cryotherapy was applied.
Treatment of Severe Drug Eruptions
Authors: Roujeau Jean‐Claude 
Published: April 2015

AbstractSevere drug eruptions are rare, life‐threatening events. The management begins with the withdrawal of the suspect drug(s). We recently confirmed that an earlier withdrawal of drugs with short elimination half‐life was associated with a better survival of patients with Stevens‐Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). In cases of “acute skin failure” (exfoliative dermatitis, extensive SJS or TEN), management of patients must be undertaken in specialized intensive care units or in burn units. The main principles of symptomatic therapy are the same as for major burns: warming of the environment, correction of electrolyte disturbances, high caloric intake, and prevention of sepsis. The suspected immunologic orgin of drug eruptions prompted the use of corticosteroids, immunosuppressive drugs, and anti‐cytokines. Systemic corticosteroids are useful in “hypersensitivity syndrome” when visceral lesions depend on infiltration by activated eosinophils. Systemic corticosteroids were shown to be deleterious in cases of advanced TEN. Their potential usefulness at earlier stages of SJS or TEN remains controversial. High intravenous doses of cyclophosphamide or oral cyclosporin have been administered to a few patients with TEN, most often following ineffective treatment with corticosteroids for 1 to 5 days. It remains doubtful that the progression of the lesions was shortened. A few patients appeared to benefit from treatment with pentoxifyllin, a drug suppressing the production of TNF. Thalidomide, another suppressor of TNF production, significantly increased the death rate when tested in a double‐blind placebo controlled trial in patients with early TEN. High dose intravenous immunoglobulins were used in 10 patients with TEN on the basis of their ability to inhibit fas‐fas ligand mediated apoptosis. The potential benefit of this treatment needs confirmation by further studies. Patients and their first degree relatives should be advised to avoid the responsible drug and chemically related compounds. Regulatory agencies should be notified of such cases.
How to Survive and Thrive under Managed Care: Lessons from U.S. Dermatologists
Authors: Emmet Steven D. 
Published: April 2015

AbstractDermatologists in the US have had many years experience in dealing with managed care and some lessons for survival and even thriving have become clear. First is to try to prevent managed care. By pointing out its history of failure in many countries it is still possible to prevent the catastrophe, to patient, physician and final payer, that managed care does represent. If prevention is not possible, minimizing its impact by promoting direct access, unbundling, and wider coverage is important. In addition, dermatologists will need to maximize reasonable sources of direct pay alternatives.
Itch and Atopic Dermatitis: An Overview
Authors: Wahlgren Carl‐Fredrik 
Published: April 2015

AbstractItching is the hallmark of atopic dermatitis, and a vicious itch‐scratch circle is easily established. Itching and scratching are important factors in the maintenance of symptoms and can have a significant impact on the sufferer's quality of life. The pathophysiology of itch in atopic dermatitis is still not understood. Unlike in urticaria, histamine is not considered to be a major pruritogen in atopic dermatitis. In fact, the peripheral pruritogens and their cellular origin(s) still remain to be identified in this disease.Various treatments are used to relieve the skin inflammation, itching, and scratching in patients with atopic dermatitis, but no specific antipruritic therapy is available. However, several nonspecific therapies can effectively break the vicious itch‐scratch circle. The use of topical corticosteroids and emollients and the elimination of individual trigger factors are still first‐line measures.
Subcutaneous Nocardial Abscesses in a Patient with Bullous Pemphigoid during Immunosuppressive Therapy: Report of a Case and Review of the Japanese Literature
Authors: Kakurai Maki , Hiraga Takeshi , Yamada Tomoko , Usui Keitaro , Kiyosawa Tomoharu , Nakagawa Hidemi 
Published: April 2015

AbstractWe describe a rare case of multiple, subcutaneous nocardial abscesses. A 67‐year‐old Japanese male with bullous pemphigoid was admitted to our hospital, and systemic prednisolone and double filtration plasmapheresis were administered. During the combination treatment, he noted a solitary subcutaneous nodule on the right upper arm. The lesions gradually increased in number and disseminated. The microbial diagnosis was thought to be a Nocardia species. Administration of combination chemotherapy with minocycline and diamino‐diphenyl sulfone failed to eliminate the nodules completely, so he was treated with daily injection of amikacin sulfate into the nodules. The lesions dramatically responded to this therapy and resolved in four weeks.
Treatments of Generalized Pustular Psoriasis: A Multicenter Study in Japan
Authors: Ozawa Akira , Ohkido Muneo , Haruki Yasuo , Kobayashi Hitoshi , Ohkawara Akira , Ohno Yoshiyuki , Inaba Yutaka , Ogawa Hideoki 
Published: April 2015

AbstractThis study analyzed data from treatments of 385 cases of generalized pustular psoriasis (GPP) from 325 hospitals in Japan. Retinoid treatment was effective in 84.1% of patients, methotrexate in 76.2%, cyclosporine in 71.2%, oral PUVA therapy in 45.7%, and tonsillectomy in 16.7%. Short‐term therapy with systemic corticosteroid for GPP during only the phase with severe systemic clinical findings may be also effective (75.4%). However, these treatments for GPP each differed in clinical effects, prognosis, and side effects. These findings may be useful in creating guidelines for treatment of generalized pustular psoriasis. Further studies based on these specific clinical effects are necessary.
Linear IgA Bullous Dermatosis Associated with Ulcerative Colitis
Authors: Chi Hyung‐In , Arai Masayo 
Published: April 2015

AbstractA 41‐year‐old woman developed skin vesicles one week before examination. She had been suffering from ulcerative colitis since the age of 30. Histologic examination of a vesicle showed a subepidermal bulla accompanied by mononuclear leukocyte infiltration intermingled with eosinophils and neutrophils. Eosinophilia was also noted. Direct immunofluorescent test revealed linear deposits of IgA in the basement membrane zone.
Pemphigus Vulgaris Preceded by Herpetiform‐like Skin Lesions with Negative Immunofluorescence Findings
Authors: Muramatsu Tsutomu , Iida Takashi , Honoki Kumiko , Nakatani Chie , Hatoko Mitsuo , Shirai Toshihiko , Vanittanakom Pramote 
Published: April 2015

AbstractWe report a case of pemphigus vulgaris in a 63‐year‐old woman. At the first onset, she developed herpetiform‐like skin lesions. Their histology showed eosinophilic spongiosis and intraepidermal blister formation with an infiltrate of eosinophils. Both direct and indirect immunofluorescence studies were negative. She remained in remission for 6 years. At the second onset, she developed bullous skin lesions; histological examination disclosed suprabasal acantholysis and infiltration of eosinophils. Direct immunofluorescence revealed IgG and C3 deposits at the cell surface, predominantly in the lower epidermis. Indirect immunofluorescence using normal human skin as a substrate demonstrated anti‐cell surface IgG antibodies at a titer of 1:160. Immunoblot analysis showed that the patient's serum reacted only with a 130kD protein. This case indicates that pemphigus vulgaris can follow herpetiform‐like skin lesions with negative immunofluorescence findings after a long remission time.
Alteration of Skin Protein Kinase C α Protein and mRNA Levels during Induced Mouse Hair Growth
Authors: Li Lin‐feng , Chang Bey‐dih , Roninson Igor B. , Fiedler Virginia C. , Kumar Raj 
Published: April 2015

AbstractProtein kinase C (PKC) has been implicated in regulation of hair growth. In this study, the role of PKC α in induced mouse hair growth was studied. Hair growth in C57BL6 mice, a well known model for hair growth research, was induced by plucking the telogen hair. PKC α protein levels during the induced hair growth cycle were analyzed by Western immunoblot and mRNA levels were measured by RT‐PCR. At 1 day and 4 days postdepilation, when the induced hair cycle was in early and midanagen, the PKC α protein level was decreased. At 10 days after depilation, when the induced hair cycle was in mature anagen, the PKC α protein level was increased. At 17 days after plucking the hair, when the induced hair cycle was in early catagen, PKC α protein returned to the control level. PKC α mRNA was relatively unchanged at 1 day and 4 days after plucking the hair but significantly elevated at 10 days postdepilation. At 17 days after hair growth induction, PKC α mRNA reverted to the control level. These results suggest that: 1) in early and mid anagen of the induced hair growth cycle, PKC α was downregulated posttranscriptionally. This downregulation may play a role in the induction of hair growth; 2) in mature anagen of induced hair growth cycle, PKC α was overexpressed, and this overexpression may play a part in maintaining the hair growth. Since the expression of PKC α was roughy correlated with mouse skin pigmentation, we hypothesize that PKC α may regulate hair growth partially through modulation of skin melanogenesis.
Leukemia Cutis in Acute Lymphocytic Leukemia Masquerading as Viral Exanthem
Authors: Chao Sheau‐Chiou , Lee J. Yu‐Yun , Tsao Chao‐Jung 
Published: April 2015

AbstractLeukemia cutis is a specific skin lesion caused by infiltration of leukemic cells into the skin. It is uncommon in acute lymphocytic leukemia (ALL). It typically manifests as red or violaceous papules, nodules, or plaques, mainly on the face. Leukemia cutis presenting with a generalized viral exanthem‐like maculopapular eruption appears to be rare in the English literature. We report such a case. A 19 year‐old man presented with a generalized purpuric maculopapular eruption of eight day's duration. Hematologic studies showed changes of acute lymphocytic leukemia, T‐cell type. A skin biopsy specimen revealed a cuff‐like, dense, perivascular infiltration of atypial lymphocytes in the upper and mid‐dermis, consistent with leukemia cutis. The rash resolved in two weeks after chemotherapy. Our case illustrates that leukemia cutis should be considered in the differential diagnosis of a generalized morbilliform viral exanthem‐like eruptions. Skin biopsy is important in estabishing the diagnosis.
Specific Cutaneous Lesions of the Scalp in Myelodysplastic Syndrome with Deletion of 20q
Authors: Namba Yumi , Koizumi Hiroko , Nakamura Hideki , Tarumi Takashi , Sawada Ken'ichi , Ohkawara Akira 
Published: April 2015

AbstractWe reported a specific skin lesion on the scalp in a patient with myelodysplastic syndrome (MDS), treated as refractory anemia with excess of blasts (RAEB). Histologically, a specimen from a nodule of the scalp consisted of a diffuse infiltration of atypical cells in the dermis and subcutaneous tissue. The patient died of acute leukemia 3 months later. Chromosomal examination of bone marrow cells revealed deletion of 20q and 21 trisomy. The specific cutaneous lesions in this patient were associated with acute transformation. The deletion of 20q and specific cutaneous lesions are regarded as signs of poor prognosis.
A Case of Classical Kaposi's Sarcoma of the Penis Showing a Good Response to High‐Energy Pulsed Carbon Dioxide Laser Therapy
Authors: Chun Yoon‐Sun , Chang Sung‐Nam , Park Wook Hwa 
Published: April 2015

AbstractIsolated Kaposi's sarcoma (KS) of the glans penis is rare; only 37 cases are reported in the literature. Treatment of KS consists mostly of old modalities, some old methods in updated improved versions, and some new and experimental therapies. We report a case of isolated classical Kaposi's sarcoma involving multiple sites of the penis in a 54‐year‐old man who was treated with high‐energy pulsed carbon dioxide (CO2) laser therapy, resulting in complete resolution of the lesions and no evidence of recurrence.