bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymphangitic Carcinomatosis of Unknown Primary: A Case Report
Authors: Shahin Md. Abu , Rahman Matiur , Dewan Gourab , Saeed Atia , Shazzad M. Nahiduzzaman , Chowdhury M.R. 
Published: November 2014

Lymphangitic carcinomatosis is an uncommon manifestation of metastasis to lung. Its presentation can mimic several disorders of the lungs. A case is presented here where patient presented with progressive dyspnoea, dry cough, weight loss and fever. The patient was amenorrheic for the last 2 years. Her physical findings were unremarkable initially other than the weight loss and evidence of pulmonary hypertension. Subsequently her dyspnoea rapidly worsened and the patient became bed bound. Investigations revealed neutrophilic leucocytosis, normal Hb with high ESR. ANA, anti Cetromere and anti Scl 70 was negative. Serum calcium was normal. Liver function test was normal other than raised alkaline phosphatase. Tuberculin test was negative. Chest X-ray revealed increased bilateral symmetrical streaks and reticulation with peripheral and lower distribution which is consistent with pulmonary lymphangitic carcinomatosis. HRCT of Lungs has shown diffuse infiltrations, reticulo-nodular and ground glass opacities, centrilobular emphysema with accentuation of broncho-vascular densities in both lung fields. There were enlarged mediastinal lymph nodes, bilateral pleural effusion. Doppler Echo revealed mild pulmonary hypertension with fair EF. Tumor markers were done. CA125, CA 19.9 and AFP were ten times higher than normal. Fibreoptic nasopharyngoesophagoscopy was normal. Diagnosis of PLC was made on clinical feature, radiological finding and elevated tumor markers. Symptomatic treatment was given during the period of evaluation. Ultimately the patient succumbed to death.DOI: http://dx.doi.org/10.3329/jssmc.v5i2.20769J Shaheed Suhrawardy Med Coll, 2013;5(2):114-116
Maryse Condé’s Victoire: Thinking Back through Her Mothers
Authors: Green Mary Jean 
Published: November 2014

In Le Cœur à rire et à pleurer (1999), Maryse Condé’s first admittedly autobiographical work, there appears a photograph of a grandmother, but the woman it pictures remains a mysterious presence. It is to the life of this unknown grandmother that Condé devotes her attention in her 2006 publication, Victoire, les saveurs et les mots. In understanding the life of this maternal grandmother, she hopes to learn more about her own enigmatic mother, and thus about herself. Condé’s text is a reconstitution of the life of Victoire Élodie Pridal, a household servant, and of the time in which she lived, when the black population of Guadeloupe was finally able to assert its right to education and political power. It is also a work of imagination, as the narrator imagines her unknown grandmother's life, comparing her own ability as a writer to the creative imagination displayed by Victoire in her legendary creole cuisine.
OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence
Authors: Buchan Sarah L. , Manzo Teresa , Flutter Barry , Rogel Anne , Edwards Noha , Zhang Lei , Sivakumaran Shivajanani , Ghorashian Sara , Carpenter Ben , Bennett Clare L. , Freeman Gordon J. , Sykes Megan , Croft Michael , Al-Shamkhani Aymen , Chakraverty Ronjon 
Published: November 2014

Abstract
Exhaustion of chronically stimulated CD8+ T cells is a significant obstacle to immune control of chronic infections or tumors. Although coinhibitory checkpoint blockade with anti–programmed death ligand 1 (PD-L1) Ab can restore functions to exhausted T cell populations, recovery is often incomplete and dependent upon the pool size of a quiescent T-bethigh subset that expresses lower levels of PD-1. In a model in which unhelped, HY-specific CD8+ T cells gradually lose function following transfer to male bone marrow transplantation recipients, we have explored the effect of shifting the balance away from coinhibition and toward costimulation by combining anti–PD-L1 with agonistic Abs to the TNFR superfamily members, OX40 and CD27. Several weeks following T cell transfer, both agonistic Abs, but especially anti-CD27, demonstrated synergy with anti–PD-L1 by enhancing CD8+ T cell proliferation and effector cytokine generation. Anti-CD27 and anti–PD-L1 synergized by downregulating the expression of multiple quiescence-related genes concomitant with a reduced frequency of T-bethigh cells within the exhausted population. However, in the presence of persistent Ag, the CD8+ T cell response was not sustained and the overall size of the effector cytokine-producing pool eventually contracted to levels below that of controls. Thus, CD27-mediated costimulation can synergize with coinhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations, but at the expense of losing precursor cells required to maintain a response.
Indian Council of Medical Research consensus document for the management of gastrointestinal stromal tumors
Authors: Shrikhande Shailesh V. , Sirohi Bhawna , Barreto Savio G. , Chacko Raju T. , Parikh Purvish M. , Pautu Jeremy , Arya Supreeta , Patil Prachi , Chilukuri Srinivas C. , Ganesh B , Kaur Tanvir , Shukla Deepak Shankar , Rath Goura 
Published: November 2014

E X E C U T I V E S U M M A R YThis consensus statement was produced along with the gastric cancer discussions as stomach is the most common site for gastrointestinal stromal tumor (GIST). The recommendations apply to treatment of GIST.Evaluation of a patient with newly diagnosed GIST should include essential tests: A standard white light endoscopy with 6-8 biopsies (c-KIT testing on immunohistochemistry) from the tumor for confirmation of the diagnosis, a computed tomography (CT) scan (multi-detector or helical) of the abdomen and pelvis for staging with a CT chest or chest X-ray, and complete blood counts, renal function tests and liver function tests. Endoscopic ultrasonography (EUS)/magnetic resonance imaging (MRI)/positron emission tomography (PET)-CT are not recommended for all patients.For localized and resectable disease, surgery is recommended. The need for adjuvant treatment with imatinib would be guided by the risk stratification on the histopathological analysis of the resected specimen.For localized but borderline resectable tumors, upfront surgery may be considered only if complications due to the tumor are present such as major bleeding or gastric outlet obstruction. In all other patients, neoadjuvant imatinib should be considered to downstage the disease followed by surgery (with a curative intent, if feasible) in those with stable or partial response. This may be followed by adjuvant imatinib. In those patients with a poor response, further imatinib with dose escalation or sunitinib may be considered.Patients with metastatic disease must be assessed for treatment with imatinib as first-line therapy followed by sunitinib as second-line therapy versus best supportive care on an individual basis.
Anticoagulation in patients with impaired renal function and with haemodialysis
Authors: Hentschel V. A.-T. , Du S. , Zolfaghari S. , Krämer R. , Weiss C. , Krämer B. K. , Wehling M. , Harenberg J. 
Published: November 2014

SummaryPatients with impaired renal function are exposed to an increased risk for bleeding complications depending on the amount of the anticoagulant eliminated by the kidneys. The elimination of unfractionated heparins, vitamin K antagonists and argatroban is only minimally influenced by a reduced renal function. Low-molecular weight heparins, fondaparinux, danaparoid, hirudins and nonvitamin K antagonist oral anticoagulants (NOAC) cause a variably increased bleeding risk in renal impairment. Dose reductions are recommended for all of these anticoagulants in renal impairment, some are even contraindicated at certain levels of renal impairment. Their benefit over the conventional anticoagulants is preserved if renal dosing is employed. For end-stage renal disease patients specific treatment regimens are required.
The Impact of a Food Elimination Diet on Collegiate Athletes’ 300-meter Run Time and Concentration
Authors: Stockton Susan , Breshears Karen , Baker David Mca. 
Published: November 2014

Background: Optimal human function and performance through diet strategies are critical for everyone but especially for those involved in collegiate or professional athletics. Currently, individualized medicine (IM) is emerging as a more efficacious approach to health with emphasis on personalized diet strategies for the public and is common practice for elite athletes. One method for directing patient-specific foods in the diet, while concomitantly impacting physical performance, may be via IgG food sensitivity and Candida albicans analysis from dried blood spot (DBS) collections. Methods: The authors designed a quasi-experimental, nonrandomized, pilot study without a control group. Twenty-three participants, 15 female, 8 male, from soccer/volleyball and football athletic teams, respectively, mean age 19.64+0.86 years, were recruited for the study, which examined preposttest 300-meter run times and questionnaire responses after a 14-day IgG DBS– directed food elimination diet based on IgG reactivity to 93 foods. DBS specimen collection, 300-meter run times, and Learning Difficulties Assessment (LDA) questionnaires were collected at the participants’ university athletics building on campus. IgG, C albicans, and S cerevisiae analyses were conducted at the Great Plains Laboratory, Lenexa, Kansas. Results: Data indicated a change in 300-meter run time but not of statistical significance (run time baseline mean=50.41 sec, run time intervention mean=50.14 sec). Descriptive statistics for frequency of responses and chi-square analysis revealed that 4 of the 23 items selected from the LDA (Listening-Memory and Concentration subscale R=.8669; Listening-Information Processing subscale R=.8517; and General Concentration and Memory subscale R=.9019) were improved posttest. Conclusion: The study results did not indicate merit in eliminating foods based on IgG reactivity for affecting athletic performance (faster 300-meter run time) but did reveal potential for affecting academic qualities of listening, information processing, concentration, and memory. Further studies are warranted evaluating IgG-directed food elimination diets for improving run time, concentration, and memory among college athletes as well as among other populations.
On the electron diffusion region in planar, asymmetric, systems
Authors: Hesse Michael , Aunai Nicolas , Sibeck David , Birn Joachim 
Published: November 2014

AbstractParticle‐in‐cell simulations and analytical theory are employed to study the electron diffusion region in asymmetric reconnection, which is taking place in planar configurations without a guide field. The analysis presented here focuses on the nature of the local reconnection electric field and on differences from symmetric configurations. Further emphasis is on the complex structure of the electron distribution in the diffusion region, which is generated by the mixing of particles from different sources. We find that the electric field component that is directly responsible for flux transport is provided not by electron pressure‐based, “quasi‐viscous,” terms but by inertial terms. The quasi‐viscous component is shown to be critical in that it is necessary to sustain the required overall electric field pattern in the immediate neighborhood of the reconnection X line.
Microscale solute transport and precipitation in complex rock during drying
Authors: Ott Holger , Andrew Matthew , Snippe Jeroen , Blunt Martin J. 
Published: November 2014

AbstractFormation drying and salt precipitation due to gas injection or production can have serious consequences for upstream operations in terms of injectivity and productivity. Recently, evidence has been found that the complexity of the pore space and microscopic capillary‐driven solute transport plays a key role in the relationship between permeability and porosity. In this study, we investigate drying and salt precipitation due to supercritical CO2 injection in single‐porosity and multiporosity systems under near well‐bore conditions. We image fluid saturation states and salt deposition by means of microcomputerized tomography scanning during desaturation. We observe capillary‐driven transport of brine and the respective solutes on the pore scale. Solute transport between porosity classes determines the distribution of the deposits in the pore space and the permeability porosity relationships—K(φ)—for flow‐through drying.
A crustal model for northern Melville Bay, Baffin Bay
Authors: Altenbernd Tabea , Jokat Wilfried , Heyde Ingo , Damm Volkmar 
Published: November 2014

AbstractThe interpretation of seismic refraction and gravity data acquired in 2010 gives new insights into the crustal structure of the West Greenland coast and the adjacent deep central Baffin Bay basin. Underneath Melville Bay, the depth of the Moho varies between 26 and 17 km. Stretched continental crust with a thickness of 25 to 14 km and deep sedimentary basins are present in this area. The deep Melville Bay Graben contains an up to ~11 km thick infill of consolidated and unconsolidated sediments with velocities of 1.6 to 4.9 km/s. Seaward, at the ~60 km wide transition between oceanic and stretched continental crust, a mount‐shaped magmatic structure is observed, which most likely formed prior to the initial formation of oceanic crust. The up to 4 km high magmatic structure is underlain by a ~2 km thick and ~50 km wide high velocity lower crust. More to the west, in the oceanic part of the Baffin Bay basin, we identify a two‐layered, 3.5 to 6 km thin igneous oceanic crust with increasing thickness toward the shelf. Beneath the oceanic crust, the depth of the Moho ranges between 11.5 and 13.5 km. In the western part of the profile, oceanic layer 3 is unusually thin (~1.5 km) A possible explanation for the thin crust is accretion due to slow spreading, although the basement is notably smooth compared to the basement of other regions formed by ultra‐slow spreading. The oceanic crust is underlain by partly serpentinized upper mantle with velocities of 7.6 to 7.8 km/s.
Nighttime ozone variability in the high latitude winter mesosphere
Authors: Smith Anne K. , López‐Puertas Manuel , Funke Bernd , García‐Comas Maya , Mlynczak Martin G. , Holt Laura A. 
Published: November 2014

AbstractWe use satellite observations and a numerical model to investigate polar nighttime ozone at the secondary maximum, around 90–95 km. Observations from the MIPAS and SABER satellite instruments indicate that the highest ozone mixing ratios are seen during the late fall to early winter period in both hemispheres and for all years examined. Simulations using the Whole Atmosphere Community Climate Model (WACCM) find qualitatively the same seasonal evolution. Analysis of WACCM results shows that the high ozone concentration is due in part to the relatively quiet dynamical conditions in early winter. The mean circulation, which brings warmer temperatures and higher concentrations of H, is weaker in early winter than during middle and late winter. H in the late fall to early winter period drops to the lowest levels seen during the year due to lack of a source from photochemistry, weak transport into the region by the mean circulation, and continual loss due to diffusive separation. The low concentration of H leads to higher ozone.
A New Technique to Map the Lymphatic Distribution and Alignment of the Penis
Authors: Long Liu Yan , Qiang Pan Fu , Ling Tao , Wei Zhang Yan , Long Zhang Yu , Shan Meng , Rong Li Shi , Li Li Hong 
Published: November 2014

ABSTRACTThe present study was to examine the distribution of lymphatic vessels in the penis of normal adult males, which could provide an anatomical basis for improvement of incisions in penile lengthening surgery, and may also help to prevent postoperative refractory edema. Thirteen normal adult male volunteers were recruited for this study. Contrast agent was injected subcutaneously in the foreskin of the penis, and after two minutes magnetic resonance lymphangiography (MRL) was performed. The acquired magnetic resonance images were analyzed to determine the changes in the number and diameter of lymphatic vessels in different parts of the penis. Maximum intensity projections (MIP) and materializes interactive medical image control system (MIMICS) were applied to analyze the overall distribution of lymphatic vessels in the penis. Magnetic resonance imaging (MRI) showed that the lymphatic vessels were in conspicuous contrast with surrounding tissues and could be clearly identified. Penile lymphatic vessels were clearly visible in the root of the penis. At the junction of the penis and the abdominal wall, all lymphatic vessels were found to be concentrated in the dorsal part of the penis. MIP two‐dimensional reconstruction showed that the overall distribution of relatively large lymphatic vessels in the dorsal and ventral parts of the penis could be seen clearly on bilateral 45° position, but not inside the abdominal wall because some of lymphatic vessels were overlapped by other tissues in the abdomen. MIMICS three‐dimensional reconstruction was able to reveal the overall spatial distribution of lymphatic vessels in the penis from any angle. The reconstruction results showed that there were 1–2 main lymphatic vessels on the root of dorsal penis, which coursed along the cavernous to the first physiological curvature of the penis. Lymphatic vessels merged on both sides of the ventral penis. At the root of the penis, lymphatic vessels gradually coursed to the dorsal surface of the penis and folded at the abdominal wall to the outside, and finally merged into the inguinal lymph nodes. The changes in distribution, number and diameter of the lymphatic vessels in the penis were observed by MRI. MIP and MIMICS reconstructions directly revealed the anatomical features of penile lymphatic vessels such as spatial distribution, overall alignment, and the relations to adjacent structures, drainage and reflux. The study will provide the anatomical basis for penile surgery, penile lymphatic reflux disorders caused by trauma or lymphatic vessels obstruction, and lymph node metastasis in penile cancer. Anat Rec, 298:1465–1471, 2015. © 2014 Wiley Periodicals, Inc.
Structural Studies and Anticancer Activity of a Novel Class of β‐Peptides
Authors: Kudryavtsev Konstantin V. , Yu Chia‐Chun , Ivantcova Polina M. , Polshakov Vladimir I. , Churakov Andrei V. , Bräse Stefan , Zefirov Nikolay S. , Guh Jih‐Hwa 
Published: November 2014

AbstractFunctionalized oligomeric organic compounds with well‐defined β‐proline scaffold have been synthesized by a cycloadditive oligomerization approach in racemic and enantiopure forms. The structure of the novel β‐peptides was investigated by NMR spectroscopic and X‐ray methods determining the conformational shapes of the β‐proline oligomers in solution and solid states. The main structural elements subject to conformational switches are β‐peptide bonds between 5‐arylpyrrolidine‐2‐carboxylic acid units existing in Z/E configurations. The whole library of short β‐peptides and intermediate acrylamides has been tested on antiproliferative activity towards the hormone‐refractory prostate cancer cell line PC‐3 revealing several oligomeric compounds with low micromolar and submicromolar activities. Bromine‐substituted dimeric and trimeric acrylamides induced caspase‐dependent apoptosis of PC‐3 cells through cell‐cycle arrest and mitochondrial damage.
Multi‐analysis strategy for metabolism of Andrographis paniculata in rat using liquid chromatography/quadrupole time‐of‐flight mass spectrometry
Authors: Li Wenlan , Sun Xiangming , Xu Ying , Wang Xuezhi , Bai Jing , Ji Yubin 
Published: November 2014

AbstractCompared with chemical drugs, it is a huge challenge to identify active ingredients of multicomponent traditional Chinese medicine (TCM). For most TCMs, metabolism investigation of absorbed constituents is a feasible way to clarify the active material basis. Although Andrographis paniculata (AP) has been extensively researched by domestic and foreign scholars, its metabolism has seldom been fully addressed to date. In this paper, high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry was applied to analysis and characterization of AP metabolism in rat urine and feces samples after oral administration of ethanol extract. The differences in metabolites and metabolic pathways between the two biological samples were further compared. The chemical structures of 20 components were tentatively identified from drug‐treated biological samples, including six prototype components and 14 metabolites, which underwent such main metabolic pathways as hydrolyzation, hydrogenation, dehydroxylation, deoxygenation, methylation, glucuronidation, sulfonation and sulfation. Two co‐existing components were found in urine and feces samples, suggesting that some ingredients' metabolic processes were not unique. This study provides a comprehensive report on the metabolism of AP in rats, which will be helpful for understanding its mechanism. Copyright © 2014 John Wiley & Sons, Ltd.
CarbonCarbon Bond Formation by Lewis Superacid Catalysis
Authors: Dunach Elisabet 
Published: November 2014

AbstractDiverse intramolecular cyclizations involving the formation of CC bonds are described using catalytic methodologies based on Lewis superacids. Examples are presented on 1,6‐diene cyclizations to gem‐dimethylcyclohexane structures. Tandem cyclization of trienes are described to afford bicyclic structures in reactions involving rearrangements. Hydroarylation of olefins and of allenes is developed in catalytic FriedelCrafts‐type coupling processes, which can give rise to tandem reactions. The olfactory evaluation of the series of prepared compounds is also presented.
Thioether Profragrances: Parameters Influencing the Performance of Precursor‐Based Fragrance Delivery in Functional Perfumery
Authors: Maddalena Umberto , Trachsel Alain , Fankhauser Peter , Berthier Damien L. , Benczédi Daniel , Wang Wei , Xi Xiujuan , Shen Youqing , Herrmann Andreas 
Published: November 2014

AbstractA series of thioether profragrances was prepared by reaction of different sulfanylalkanoates with δ‐damascone and tested for their release efficiencies in a fabric‐softener and an all‐purpose cleaner application. Dynamic headspace analysis on dry cotton and on a ceramic plate revealed that the performance of the different precursors depended on the structure, but also on the particular conditions encountered in different applications. Moreover, profragrances derived from other α,β‐unsaturated fragrance aldehydes and ketones were synthesized analogously and evaluated using the same test protocol. Thioethers were found to be suitable precursors to release the corresponding fragrances, but neither the quantity of profragrance deposited from an aqueous environment onto the target surface, nor the amount of fragrance released after deposition could be linearly correlated to the hydrophilicity or hydrophobicity of the compounds. Different sets of compounds were found to be the best performers for different types of applications. Only one of the compounds evaluated in the present work, namely the thiolactic acid derivative of δ‐damascone, efficiently released the corresponding fragrance in both of the tested applications. Profragrance development for functional perfumery thus remains a partially empirical endeavour. More knowledge (and control) of the various application conditions are required for an efficient profragrance design.