bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized controlled dismantling trial of post-workshop consultation strategies to increase effectiveness and fidelity to an evidence-based psychotherapy for Posttraumatic stress disorder
Authors: Wiltsey Stirman Shannon , Shields Norman , Deloriea Josh , Landy Meredith SH , Belus Jennifer M , Maslej Marta M , Monson Candice M 
Published: August 2013

AbstractBackgroundPosttraumatic Stress Disorder (PTSD) is a serious mental health condition with substantial costs to individuals and society. Among military veterans, the lifetime prevalence of PTSD has been estimated to be as high as 20%. Numerous research studies have demonstrated that short-term cognitive-behavioral psychotherapies, such as Cognitive Processing Therapy (CPT), lead to substantial and sustained improvements in PTSD symptoms. Despite known benefits, only a minority of clinicians provide these therapies. Transferring this research knowledge into clinical settings remains one of the largest hurdles to improving the health of veterans with PTSD. Attending a workshop alone is insufficient to promote adequate knowledge transfer and sustained skill; however, relatively little research has been conducted to identify effective post-training support strategies.MethodsThe current study investigates whether clinicians receiving post-workshop support (six-month duration) will deliver CPT with greater fidelity (i.e., psychotherapy adherence and competence) and have improved patient outcomes compared with clinicians receiving no formal post-workshop support. The study conditions are: technology-enhanced group tele-consultation; standard group tele-consultation; and fidelity assessment with no consultation. The primary outcome is independent assessment (via audio-recordings) of the clinicians’ adherence and competence in delivering CPT. The secondary outcome is observed changes in patient symptoms during and following treatment as a function of clinician fidelity. Post-consultation interviews with clinicians will help identify facilitators and barriers to psychotherapy skill acquisition. The study results will inform how best to implement and transfer evidence-based psychotherapy (e.g., CPT) to clinical settings to attain comparable outcomes to those observed in research settings.DiscussionFindings will deepen our understanding of how much and what type of support is needed following a workshop to help clinicians become proficient in delivering a new protocol. Several influences on clinician learning and patient outcomes will be discussed. An evidence-based model of clinical consultation will be developed, with the ultimate goal of informing policy and influencing best practice in clinical consultation.Trial registrationClinicalTrials.gov:NCT01861769
Electrons for intraoperative radiotherapy in selected breast-cancer patients: late results of the Montpellier phase II trial
Authors: Lemanski Claire , Azria David , Gourgou-Bourgade Sophie , Ailleres Norbert , Pastant Aurelie , Rouanet Philippe , Fenoglietto Pascal , Dubois Jean-Bernard , Gutowski Marian 
Published: August 2013

Abstract

Background
The Montpellier cancer institute phase II trial started in 2004 and evaluated the feasibility of intraoperative radiotherapy (IORT) technique given as a sole radiation treatment for patients with an excellent prognostic and very low recurrence risk.

Methods
Forty-two patients were included between 2004 and 2007. Inclusion criteria were patients ≥ 65 years old, T0-T1, N0, ductal invasive unifocal carcinoma, free-margin > 2 mm. IORT was delivered using dedicated linear accelerator. One fraction of 21 Gy was prescribed and specified at the 90% isodose using electrons. In vivo dosimetry was performed for all patients. Primary end-point was the quality index. Secondary endpoints were quality of life, local recurrences, cosmetic results, specific and overall survival.

Results
At inclusion, median age was 72 years (range, 66–80). Median tumor diameter was 10 mm. All patients received the total prescribed dose. No acute grade 3 toxicities were observed. Late cosmetic results were good at 5 years despite the poor agreement of accuracy assessment between patients and physicians. Four patients (9.5%) experienced a local failure and underwent salvage mastectomy. The 5 year-disease free survival is 92.7% (range 79.1−97.6). All patients are still alive with a median follow-up of 72 months (range 66–74).

Conclusion
Our results confirm with a long-term follow-up that exclusive partial breast IORT is feasible for early-breast cancer in selected patients. IORT provides good late cosmetics results and should be considered as a safe and very comfortable “one-step” treatment procedure. Nevertheless, patient assessments are essential for long-term quality results.
Identification of early and distinct glioblastoma response patterns treated by boron neutron capture therapy not predicted by standard radiographic assessment using functional diffusion map
Authors: Hiramatsu Ryo , Kawabata Shinji , Furuse Motomasa , Miyatake Shin-Ichi , Kuroiwa Toshihiko 
Published: August 2013

Abstract

Background
Radiologic response of brain tumors is traditionally assessed according to the Macdonald criteria 10 weeks from the start of therapy. Because glioblastoma (GB) responds in days rather than weeks after boron neutron capture therapy (BNCT) that is a form of tumor-selective particle radiation, it is inconvenient to use the Macdonald criteria to assess the therapeutic efficacy of BNCT by gadolinium-magnetic resonance imaging (Gd-MRI). Our study assessed the utility of functional diffusion map (fDM) for evaluating response patterns in GB treated by BNCT.

Methods
The fDM is an image assessment using time-dependent changes of apparent diffusion coefficient (ADC) in tumors on a voxel-by-voxel approach. Other than time-dependent changes of ADC, fDM can automatically assess minimum/maximum ADC, Response Evaluation Criteria In Solid Tumors (RECIST), and the volume of enhanced lesions on Gd-MRI over time. We assessed 17 GB patients treated by BNCT using fDM. Additionally, in order to verify our results, we performed a histopathological examination using F98 rat glioma models.

Results
Only the volume of tumor with decreased ADC by fDM at 2 days after BNCT was a good predictor for GB patients treated by BNCT (P value = 0.022 by log-rank test and 0.033 by wilcoxon test). In a histopathological examination, brain sections of F98 rat glioma models treated by BNCT showed cell swelling of both the nuclei and the cytoplasm compared with untreated rat glioma models.

Conclusions
The fDM could identify response patterns in BNCT-treated GB earlier than a standard radiographic assessment. Early detection of treatment failure can allow a change or supplementation before tumor progression and might lead to an improvement of GB patients’ prognosis.
Pure 16q21q22.1 deletion in a complex rearrangement possibly caused by a chromothripsis event
Authors: Genesio Rita , Ronga Valentina , Castelluccio Pia , Fioretti Gennaro , Mormile Angela , Leone Graziella , Conti Anna , Cavaliere Maria Luigia , Nitsch Lucio 
Published: August 2013

Abstract

Background
Partial monosomies of chromosome 16q are rare and overlapping effects from complex chromosomal rearrangements often hamper genotype-phenotype correlations for such imbalances. Here, we report the clinical features of an isolated partial monosomy 16q21q22.1 in a boy with a complex de novo rearrangement possibly resulting from a chromothripsis event.

Results
The patient presented with low birth weight, microcephaly, developmental delay, facial dysmorphisms, short stature, dysmorphic ears and cardiopathy. Standard and molecular cytogenetics showed a complex rearrangement characterised by a pericentromeric inversion in one of chromosomes 12 and an inverted insertional translocation of the 12q14q21.1 region, from the rearranged chromosome 12, into the q21q22.1 tract of a chromosome 16. Array-CGH analysis unravelled a partial 16q21q22.1 monosomy, localised in the rearranged chromosome 16.

Conclusions
The comparison of the present case to other 16q21q22 monosomies contributed to narrow down the critical region for cardiac anomalies in the 16q22 deletion syndrome. However, more cases, well characterised both for phenotypic signs and genomic details, are needed to further restrict candidate regions for phenotypic signs in 16q deletions. The present case also provided evidence that a very complex rearrangement, possibly caused by a chromothripsis event, might be hidden behind a classical phenotype that is specific for a syndrome.
A novel angiomatoid epithelioid sarcoma cell line, Asra-EPS, forming tumors with large cysts containing hemorrhagic fluid in vivo
Authors: Imura Yoshinori , Naka Norifumi , Outani Hidetatsu , Yasui Hirohiko , Takenaka Satoshi , Hamada Ken-ichiro , Ozaki Ritsuro , Kaya Mitsunori , Yoshida Ken-ichi , Morii Eiichi , Myoui Akira , Yoshikawa Hideki 
Published: August 2013

AbstractBackgroundWhereas we can use several human epithelioid sarcoma (ES) cell lines for basic and preclinical research, an angiomatoid ES cell line has not been reported to date. We have treated a case of an angiomatoid ES developing in the right upper extremity of a 67-year-old man.MethodsAn angiomatoid ES cell line, Asra-EPS was newly established and characterized for its morphology, growth rate and chromosomal analysis. Tumorigenicity of Asra-EPS cells was also analyzed in athymic nude mice.ResultsAsra-EPS cells were round, polygonal or spindle-shaped with an abundant cytoplasm and have been maintained continuouslyin vitrofor over 150 passages during more than 15 months. These cells secreted cancer antigen 125 (CA 125), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) into the culture medium. Asra-EPS cells were tumorigenic when implanted in nude mice with tumors reaching a volume of 1000 mm3at around 50 days. Histological features of tumors formed in mice were essentially the same as those of the original tumor, exhibiting a multinodular proliferation of eosinophilic epithelioid and spindle-shaped cells with prominent areas of hemorrhage and blood-filled cystic spaces strikingly corresponding to the potential of hemorrhagic cyst formation in the original tumor. They showed immunopositive staining for cytokeratins (AE1/AE3 and CAM5.2), epithelial membrane antigen (EMA), vimentin, CD31, CD34 and CA 125, but negative for integrase interactor 1 (INI-1) and factor VIII-related antigen.ConclusionsThe established cell line represents a biologically relevant new tool to investigate the molecular pathology of human angiomatoid ES and to evaluate the efficacy of novel therapeutics bothin vitroandin vivo.
Development of children's hymenoptera venom allergy quality of life scale (CHVAQoLS)
Authors: Cichocka‐Jarosz Ewa , Brzyski Piotr , Tobiasz‐Adamczyk Beata , Lis Grzegorz , Pietrzyk Jacek J 
Published: August 2013

AbstractBackgroundVenom allergy is a rare but life‐threatening disease and may have a considerable impact on the health‐related quality of life (HRQoL) of patients, especially children. This paper presents development of the HRQoL scale for children and adolescents with Hymenoptera venom allergy (HVA).MethodsThe study sample consisted of 71 children, born between 1992 and 2000, who presented with a history of insect sting reaction when referred for consultation in the allergy center of Polish‐American Children's Hospital, Krakow, Poland, during the period from 2000 to 2010. The initial pool of 60 items ‐ divided into 6 domains ‐ was prepared. The items with intercorrelations higher than 0.7 were removed from each domain and then principal component analysis was conducted for each domain separately, to provide a one‐dimensional subscale for each domain. Reliability of the subscales was assessed using Cronbach alpha coefficient in terms of Classical Test Theory and with rho coefficient in terms of Item Response Theory. The multidimensionality of the scale was tested using multi‐trait scaling.ResultsThree to four items from each domain were subsequently selected to constitute six subscales. Rho coefficients for all the subscales reached 0.8, similar results were achieved with the Cronbach alpha coefficients. Multi‐trait method showed that the majority of the items indicated stronger correlations with their own subscales than with other subscales, which proves that our constructed subscales measure different dimensions of HRQoL.ConclusionsThe presented scale comprises high validity and reliability subscales measuring six dimensions of HRQoL related to Hymenoptera venom allergy in children and adolescents. Such information may be useful in everyday clinical practice.
Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies
Authors: Steinbach Anke , Maurer Christine K , Weidel Elisabeth , Henn Claudia , Brengel Christian , Hartmann Rolf W , Negri Matthias 
Published: August 2013

Abstract

Background
PQS (Pseudomonas Quinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that induces virulence factor production and biofilm formation. The enzyme PqsD catalyses the biosynthesis of HHQ.

Results
Enzyme kinetic analysis and surface plasmon resonance (SPR) biosensor experiments were used to determine mechanism and substrate order of the biosynthesis. Comparative analysis led to the identification of domains involved in functionality of PqsD. A kinetic cycle was set up and molecular dynamics (MD) simulations were used to study the molecular bases of the kinetics of PqsD. Trajectory analysis, pocket volume measurements, binding energy estimations and decompositions ensured insights into the binding mode of the substrates anthraniloyl-CoA and β-ketodecanoic acid.

Conclusions
Enzyme kinetics and SPR experiments hint at a ping-pong mechanism for PqsD with ACoA as first substrate. Trajectory analysis of different PqsD complexes evidenced ligand-dependent induced-fit motions affecting the modified ACoA funnel access to the exposure of a secondary channel. A tunnel-network is formed in which Ser317 plays an important role by binding to both substrates. Mutagenesis experiments resulting in the inactive S317F mutant confirmed the importance of this residue. Two binding modes for β-ketodecanoic acid were identified with distinct catalytic mechanism preferences.
Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses
Authors: Gouspillou Gilles , Picard Martin , Godin Richard , Burelle Yan , Hepple Russell T 
Published: August 2013

Abstract
Aging-related loss of muscle mass, a biological process named sarcopenia, contributes to mobility impairment, falls, and physical frailty, resulting in an impaired quality of life in older people. In view of the aging of our society, understanding the underlying mechanisms of sarcopenia is a major health-care imperative. Evidence obtained from human and rodent studies demonstrates that skeletal muscle denervation/reinnervation cycles occur with aging, and that progressive failure of myofiber reinnervation is a major cause of the accelerating phase of sarcopenia in advanced age. However, the mechanisms responsible for the loss of myofiber innervation with aging remain unknown. The two major strategies that counteract sarcopenia, that is, caloric restriction and endurance training, are well known to protect neuromuscular junction (NMJ) integrity, albeit through undefined mechanisms. Interestingly, both of these interventions better preserve PGC-1α expression with aging, a transcriptional coactivator which has recently been shown to regulate key proteins involved in maintaining NMJ integrity. We therefore propose that the aging-related decline in PGC-1α may be a central mechanism promoting instability of the NMJ and consequently, aging-related alterations of myofiber innervation in sarcopenia. Similarly, the promotion of PGC-1α expression by both caloric restriction and exercise training may be fundamental to their protective benefits for aging muscle by better preserving NMJ integrity.
Participation and performance trends in ‘Ultraman Hawaii’ from 1983 to 2012
Authors: Meili Dimirela , Knechtle Beat , Rüst Christoph Alexander , Rosemann Thomas , Lepers Romuald 
Published: August 2013

Abstract

Background
Participation and performance trends have been investigated in a single stage Ironman triathlon such as the ‘Ironman Hawaii,’ but not for a multi-stage ultra-triathlon such as the ‘Ultraman Hawaii’ covering a total distance of 515 km. The aims of this study were to analyze (1) changes in participation and performance, (2) sex-related differences in overall and split time performances, and (3) the age of peak performance in Ultraman Hawaii.

Methods
Age and race times including split times for 98 women and 570 men who successfully finished Ultraman Hawaii (day 1 with 10-km swimming and 145-km cycling, day 2 with 276-km cycling, and day 3 with 84-km running) between 1983 and 2012 were analyzed. Changes in variables over time of annual winners and annual top three women and men were investigated using simple linear regression analyses.

Results
The number of female finishers increased (r
2 = 0.26, p < 0.01), while the number of male finishers remained stable (r
2 = 0.03, p > 0.05). Overall race times decreased for both female (r
2 = 0.28, p < 0.01) and male (r2 = 0.14, p < 0.05) winners and for both the annual top three women (r
2 = 0.36, p < 0.01) and men (r2 = 0.14, p = 0.02). The sex difference in performance decreased over time from 24.3% to 11.5% (r
2 = 0.39, p < 0.01). For the split disciplines, the time performance in cycling on day 1 (r
2 = 0.20, p < 0.01) and day 2 decreased significantly for men (r
2 = 0.41, p < 0.01) but for women only on day 2 (r
2 = 0.45, p < 0.01). Split times showed no changes in swimming and running. The age of the annual winners increased from 28 to 47 years for men (r
2 = 0.35, p < 0.01) while it remained stable at 32 ± 6 years for women (r
2 < 0.01, p > 0.05). The age of the annual top three finishers increased from 33 ± 6 years to 48 ± 3 years for men (p < 0.01) and from 29 ± 7 years to 49 ± 2 years for women (p < 0.01).

Conclusions
Both the annual top three women and men improved performance in Ultraman Hawaii during the 1983–2012 period although the age of the annual top three women and men increased. The sex-related difference in performance decreased over time to reach approximately 12% similar to the reports of other endurance and ultra-endurance events. Further investigations are required to better understand the limiting factors of the multi-activities ultra-endurance events taking place over several days.
The effects of international migration on the well-being of native populations in Europe
Authors: Betz William , Simpson Nicole B 
Published: August 2013

Abstract
Very little is understood about how immigrants affect the happiness, or subjective well-being of natives. We use the European Social Survey to analyze the effects of aggregate immigration flows on the subjective well-being of native-born populations in a panel of 26 countries between 2002 and 2010. We find that recent immigrant flows have a nonlinear, yet overall positive impact on the well-being of natives, with the largest effects coming from immigrant flows arriving in the previous year. Our results are small in magnitude and in practical application; only large immigrant flows would affect native well-being significantly.

JEL codes

F22, I31, O15
Predicting mandibular growth increment on the basis of cervical vertebral dimensions in Iranian girls
Authors: Moshfeghi Mahkameh , Rahimi Hajir , Rahimi Hoda , Nouri Mahtab , Bagheban Alireza Akbarzadeh 
Published: August 2013

Abstract

Background
The purpose of this longitudinal study was to establish an equation to predict incremental mandibular length on the basis of the analysis of the cervical vertebrae on a single cephalometric radiograph and to compare the predictive accuracy with the method by Mito et al.

Methods
Data consist of a group of 33 Iranian girls, 9 to 11 years old with two lateral cephalometric radiographs taken at a 24-month interval. For each individual, on the lateral cephalometric radiographs, points and lines for the description of the morphologic characteristics of the third and fourth cervical vertebral bodies were traced and measured. The real mandibular length increment (MLI) in this period was determined by the difference between the second (24 months) and first (baseline) radiographs: MLI = Ar-Pog (second) − Ar-Pog (first). An equation was determined to calculate mandibular length increments on the basis of the measurements in the third and fourth cervical vertebral bodies. The predictive accuracy was assessed using multiple regression analysis.

Results
The adjusted R
2 for this equation was 54.9% which is a reliable value for evaluating prediction accuracy .The average error between the predicted increment and the actual increment was 0.149 mm for our method and 5.87 mm for the method by Mito et al.

Discussion
There are two items that contributed to easier and better prediction accuracy in our equation: (1) higher R
2 and (2) fewer independent variables. In our subjects, the prediction accuracy was lower when using Mito et al.'s method, which could be due to genetic and environmental factors and selected age range.

Conclusion
These results indicate that cervical vertebral measurements, obtained in lateral cephalograms, are able to predict properly the mandibular growth potential.
Frictional resistance in monocrystalline ceramic brackets with conventional and nonconventional elastomeric ligatures
Authors: Galvão Mariana Bulhoes , Camporesi Matteo , Tortamano André , Dominguez Gladys Cristina , Defraia Efisio 
Published: August 2013

Abstract

Background
The objective of this study was to compare the frictional forces generated by three types of monocrystalline ceramic brackets coupled with conventional elastomeric ligatures (CEL) and nonconventional elastomeric ligatures (NCEL) during the alignment of apically displaced teeth at the maxillary arch.

Methods
All tests (a total of 480 tests) were carried out in a dry state on a universal testing machine with a testing model consisting of three 0.022-in. monocrystalline ceramic preadjusted brackets (from the maxillary right second premolar through the right central incisor). The canine bracket was bonded to a sliding bar that allowed for different vertical positions. The frictional forces generated by a 0.012- and 0.014-in. superelastic nickel titanium wire (SENT) with conventional and nonconventional ligatures at various amounts of canine misalignment (1.5, 3.0, 4.5, and 6.0 mm) were recorded. Comparisons between the different types of bracket-wire-ligature systems were carried out by means of analysis of variance on ranks with Tukey's post hoc test (P < 0.05).

Results
No significant differences were assessed among the three types of monocrystalline brackets with NCEL when coupled with 0.012-in. SENT. Radiance brackets with NCEL coupled with 0.014-in. SENT showed significantly greater frictional force than Inspire Ice brackets and Pure brackets with NCEL. A significantly greater amount of frictional force was generated with CEL when compared with NCEL for all the tested variables, with the exception of the Pure brackets with 0.012-in. SENT at 1.5 and 3.0 mm of canine misalignment where similar frictional forces were found.

Conclusions
Nonconventional elastomeric ligatures are able to reduce friction in monocrystalline ceramic brackets.