bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genesis of the development of the category of trust and mistrust in science
Authors: Litvina K. Ya. 
Published: July 2024

The Relevance. The initial manifestations of trust were recorded in the political philosophy of Ancient Greece and Ancient China, on the basis of which thinkers determined the interconnection and interdependence of relations between government and society. Further developing in line with political sociology, trust as the principle of “fides” (“faith”) from the Roman law was conceptualized by M. Weber as an “emotional product” of a social contract, violation of the terms of which does not carry sanctions, with the exception of the loss of business reputation. The category of trust was significantly enriched during the development of sociology of the 20th – early 21st centuries, and thanks to the works of P. Sztompka and F. Fukuyama, it gained understanding of the conditions for sustainable development of society in conditions of uncertainty, in which the individual proceeds from the “credit” of confidence in the respectable behavior of another and absolute confidence in one's own actions. In recent years, a “crisis of confidence” in science as a social institution in modern society has been recorded.The problem of the research is to identify the peculiarities of understanding the category of “trust” by the classics of sociological science and their applicability in modern science.The goal of the research is to study the relationship between the dynamics of trust in Sociology in the scientific community and in science as a social institution as a whole.The methodological basis of the reseearch is a systematic approach and general methods of scientific knowledge, such as analysis, synthesis, generalization.The Research results. The classics of sociological science have enriched the motivational, value and political meanings of the concept of «trust» in modern science.
A model for developing the readiness of future teachers to design a psychologically safe environment
Authors: Dzhabatyrova B. K. , Hatit F. R. , Stash N. M. 
Published: July 2024

During the period of paradigmatic changes in the life of society, there is a growing trend of uncertainty, which determines emotional tension, increased levels of aggression and anxiety. The dynamism and transitivity of social processes determine the choice of strategy for social behavior and human development in situations of unpredictability and complexity. In these conditions, the problem of creating psychologically comfortable conditions for the comprehensive development of an individual, his/her security in the process of interaction between subjects of the educational process, which requires teachers to be prepared to design and create a psychologically safe educational environment, acquires special significance. In this regard, the research problem lies in the scientific substantiation and practical development of a model for developing the readiness of future teachers to design a psychologically safe environment. The goal of the research is to develop a model for developing the readiness of future teachers to design a psychologically safe environment. The methodological basis of the research is represented by a set of methods of analysis, modeling, design, and experiment.The results of the research: various approaches to the content of a future teacher’s readiness to design a psychologically safe educational environment have been analyzed; the structural components of readiness have been identified, the criteria and indicators of its formation have been determined. A model has been designed for developing the readiness of a future teacher to design a psychologically safe educational environment.Key conclusions: the relevance of the problem of developing readiness to design a psychologically safe environment in the process of professional training of future teachers is due to modern social transformations; The model for the formation of readiness is a set of target, content-procedural, technological and evaluative-reflective components, focused on the formation of motivation in teaching activities, improving the design competence of future teachers, and developing personal and professional qualities of future teachers.
Foreign language olympiads as a way to increase motivation for its studying in the educational paradigm of higher education
Authors: Kolesnichenko A. N. , Simonova O. B. 
Published: July 2024

The relevance of the research problem is substantiated by the fact that this procedure creates the basis for developing students’ interest in constant progress in mastering foreign languages (i.e., it increases the level of motivation to learn a foreign language), in systematizing and deepening knowledge of a foreign language. The scope of the research is a consideration and description of the methodology for holding foreign language olympiads as a motivation factor in learning. Thegoal of the research is to prove the positive impact of holding an online Foreign Language Olympiad on motivation in learning a foreign language.The research objectives: to analyze the experience of holding foreign language olympiads, to develop practical advice on the methodology for conducting such procedures. Methods used by the authors to illuminate the stated issues: comparative analysis of sources on the above-mentioned topics, experimental method, statistical mathematical method of data processing – Student's T-test. The results of the research has proved hypothesis about the positive impact of holding olympiads on motivation in learning a foreign language through appropriate scientific research methods. It has been concluded that the results can be recommended as a tool for conducting olympiads of this kind both at the university and at other levels of education.
An Optimized Framework Based on Data Exploration and Dynamic Ensemble-Based Models for Breast Cancer Prediction
Authors: Alsabry Ayman , Qasem Hamzah Ali Abdulrahman , Algabri Malek , Ahsan Amin Mohamed , Mosleh Mogeeb A. A. , Hanash F. E. 
Published: July 2024

Breast cancer (BC) is a major global health concern. Detecting BC at an early stage gives more treatment options and can help avoid more aggressive treatments. The use of machine learning (ML) in BC prediction offers significant potential for improving the accuracy and speed of diagnosis, personalizing treatment, and identifying high-risk patients. However, there are significant challenges associated with the use of ML, including the need for high-quality data and more flexible models with optimal parameters to achieve high efficiency. In this paper, we propose an optimized framework based on multi-stage data exploration. This framework is designed to provide a comprehensive approach to data exploration, ensuring that the data is well-prepared for ML. In addition, the framework includes dynamic ensemble-based classifiers, which combine multiple independent classifiers to improve accuracy and mitigate the risk of overfitting in conjunction with the cross-validation techniques. These classifiers are optimized using Bayesian hyperparameter tuning, which involves selecting the optimal values for the various hyperparameters of the model. This approach can significantly improve the prediction accuracy of the resulting model. The study evaluates the framework using the publicly available Wisconsin Diagnostic Breast Cancer (WDBC) dataset and compares our results with other state-of-the-art models. The experimental results show that the best result is 100% for accuracy and recall with hyperparameters of (Ensemble Method = AdaBoost, Number of learners = 322, learning rate = 0.9350, and the Maximum number of splits = 1). The highest performance has been achieved with the proposed framework compared with the other models in terms of accuracy (mean = 99.35%, best = 100%, worst = 98.7%, and Standard Deviation = 0.325). The framework can potentially improve the accuracy and efficiency of BC prediction, ultimately leading to better outcomes for patients.
PROPUESTA DE VALOR, FACTOR CLAVE PARA EL ÉXITO DE LOS EMPRENDIMIENTOS
Authors: Mora Aristega Julio Ernesto , García León Erika Paola , Ley Leiva Nelly Victoria 
Published: July 2024

Una propuesta es uno de los elementos claves del posicionamiento de una empresa, es una herramienta esencial para enfocarse en lo que más importa y servirá de base para las campañas de marketing y argumentos de venta, además es la carta de presentación ante los clientes. Una buena propuesta debe destacar lo que hace diferente a una empresa o servicios de los competidores, pero siempre debe centrarse en cómo los clientes definen el valor. La propuesta de valor es definida también como un punto de inflexión entre la estrategia empresarial y la estrategia de marca, sin embargo, muchas empresas suelen mezclar ambas dimensiones y terminan adoptando una propuesta demasiado vaga o general, o incluso olvidándose de tener una; en este trabajo se muestran las características que deben tener, las consideraciones a tener en cuenta previo a la generación de una propuesta de valor para los clientes, además de los elementos necesarios durante el desarrollo de la misma; considerando el mercado, la experiencia, el producto o servicio y las alternativas y diferencias que existen entre nuestro producto y la competencia.
AUDITORÍA
Authors: Borbones S. Víctor , Martínez González Clímaco 
Published: July 2024

Esta investigación va dirigida a los colaboradores de la Oficina de Fiscalización de Prestaciones Económicas, para facilitar la revisión de los expedientes de indemnizaciones por vejez. Es un modelo de trabajo para los fiscalizadores, permitiendo una mejora continua en el desarrollo de sus labores cotidianas y de igual manera indujo al personal que rota o llega nuevo, en el desarrollo de sus labores. Se utilizó un cuestionario, como instrumento de aplicación metodológica para obtener la información requerida de la unidad de Fiscalización para conocer el procedimiento existente. Entre los resultados esperados sugirió un fuerte apoyo para la implementación de un modelo a seguir de fiscalización para unificar criterios, facilitar trámite de verificación y refrendo.
LINC00847 drives pancreatic cancer progression by targeting the miR-455-3p/HDAC4 axis
Authors: Hao Shunxin , Yao Zhi , Liu Yifeng 
Published: July 2024

IntroductionPancreatic cancer (PC) is a common malignant tumor of the digestive system, posing a serious threat to the life of patients. This study aims to investigate the role of LINC00847 and the LINC00847/miR-455-3p/HDAC4 mechanism in PC progression.Material and methodsThe RNA levels of LINC00847, miR-455-3p and HDAC4 were determined by RT-qPCR. HDAC4 protein level was assessed by western blotting. Colony formation and CCK-8 assays were employed to test the proliferation of PC cells. Transwell and scratch assays were conducted to evaluate the cell invasive and migratory abilities, respectively. The effect of LINC00847 silencing on PC cells in vivo was verified using a mouse xenograft model. The correlation among LINC00847, miR-455-3p and HDAC4 was ascertained by dual-luciferase reporter (DLR) assay and Pearson’s correlation analysis.ResultsThe result showed that LINC00847 mainly localized in the cytoplasm was upregulated in PC cells and tissues. Downregulating LINC00847 hindered migration, proliferation, and invasion of PC cells in vitro. Moreover, it also suppressed tumor growth in an in vivo xenograft model. LINC00847 was found to directly target miR-455-3p. miR-455-3p overexpression inhibited cell proliferation and invasion. In addition, HDAC4 was confirmed to be a target gene of miR-455-3p, and HDAC4 overexpression overturned the impact of LINC00847 knockdown on PC cell progression.ConclusionsOur findings reveal that LINC00847 potentially plays a key role in the carcinogenesis of PC progression. This effect may be mediated via regulating the miR-455-3p/HDAC4 axis. This study provides insights into the intricate molecular mechanisms underlying PC and opens avenues for potential therapeutic interventions.
Women suffering from systemic lupus erythematosus are characterized by low blood levels of α-dicarbonyl compounds
Authors: Nowak Agnieszka , Przywara-Chowaniec Brygida , Damasiewicz-Bodzek Aleksandra , Janoszka Beata , Szumska Magdalena , Waligóra Sławomir , Tyrpień-Golder Krystyna 
Published: July 2024

IntroductionSystemic lupus erythematosus (SLE) is a chronic, autoimmune disease, often characterised by severe course and unclear etiopathogenesis. The reaction of protein glycoxidation, also known as glycation, may be linked to etiopathogenesis of SLE. Advanced glycation end-products (AGEs) exhibit cytotoxic properties, affect cellular signalling, impair functions of extracellular proteins, and may act as neoepitopes. Glucosone (GS), glyoxal (GO), and methylglyoxal (MGO) are examples of α-dicarbonyl compounds (α-DCs) partaking in glycoxidation. The study aimed to evaluate concentrations of these three compounds in blood serum of SLE patients, and to compare the results with healthy individuals.Material and methods31 women suffering from SLE and 26 healthy individuals were included in the study. High-performance liquid chromatography with fluorescence detection was applied to evaluate concentrations of α-DCs in their serum samples. Correlations between the results and parameters such as disease duration time, age, glomerular filtration rate (GFR), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and creatinine were analysed.ResultsThe SLE patients exhibited lower concentrations of glucosone, glyoxal, and methylglyoxal than the control group. Analysis of correlations showed a difference between the examined groups.ConclusionsIn women suffering from SLE the course of α-DCs metabolism is altered. SLE patients are characterised by low serum levels of α-DCs. We hypothesise that either hindered proteasomal degradation or fast consumption of α-DCs in oxidative conditions may cause the observed low concentration of these compounds.
Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction
Authors: Banjac Katarina , Obradovic MIlan , Zafirovic Sonja , Isenovic Esma R. 
Published: July 2024

IntroductionInsulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption.MethodsMale Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised. The level of interaction between Beclin-1 and the α<sub>1</sub> subunit of sodium/potassium-adenosine triphosphates (Na<sup>+</sup>/K<sup>+</sup>-ATPase), and phosphorylated forms of IGF-1 receptor/insulin receptor (IGF-1R/IR), forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK) were measured.ResultsThe results indicate that IGF-1 decreased Beclin-1’s association with Na<sup>+</sup>/K<sup>+</sup>-ATPase (<i>p</i> < 0.05), increased IGF-1R/IR and FOXO1 phosphorylation (<i>p</i> < 0.05), and decreased AMPK phosphorylation (<i>p</i> < 0.01) in rats’ hearts.ConclusionsThe new IGF-1 therapy may control autosis and minimize cardiomyocyte mortality.
Acute renal failure caused by Sjögren’s syndrome and rheumatoid arthritis overlap syndrome
Authors: Ran Lei , Zhang Ya-pu , Guo Li , Wang Zhi-min , Zhang Jian-min 
Published: July 2024

IntroductionSjögren’s syndrome (SS) and rheumatoid arthritis (RA) are two chronic autoimmune diseases. To date, there have been few reports on the overlap between SS and RA in China, especially regarding correlated acute renal failure cases.Material and methodsTo provide a reference for our clinical peers, this article presents the case report of an elderly female patient who was diagnosed with acute renal failure caused by SS and RA overlap syndrome.ResultsWe also provide a relevant analysis of SS and RA overlap syndrome treatment.ConclusionsWe also provide a relevant analysis of SS and RA overlap syndrome treatment.
Product strategy development and financial modeling in AI and Agritech Start-ups
Authors: Eyitayo Raji  , Tochukwu Ignatius Ijomah  , Osemeike Gloria Eyieyien  
Published: July 2024

This paper explores the intricate dynamics of product strategy development and financial modeling within the burgeoning fields of AI and agritech start-ups. It begins by delineating the stages of product development—from idea generation and market research to launch and scaling—emphasizing customer-centricity, innovation, and collaborative partnerships as pivotal drivers of success. Financial modeling techniques, ranging from basic revenue and cost structures to advanced scenario analysis and risk mitigation, are examined for their role in guiding strategic decision-making and ensuring financial sustainability. In the AI sector, rapid advancements in machine learning and data analytics are reshaping industries through intelligent automation and predictive insights. Agritech, meanwhile, leverages technology to optimize agricultural processes, enhance productivity, and promote sustainable practices amid global challenges. Both sectors share synergies in integrating AI technologies to innovate product offerings and enhance financial performance, albeit facing distinct challenges such as regulatory compliance and market adoption. Practical examples illustrate how AI and agritech start-ups apply these insights to refine product strategies and financial models, enhancing market competitiveness and scalability. The implications for practice underscore the importance of adapting to market dynamics, leveraging technological innovations, and fostering strategic collaborations to drive growth and innovation.
Keywords: AI, Agritech, Product Strategy Development, Financial Modeling, Start-Ups
Metode Pembelajaran Pada Mahasiswa Kebidanan Dalam Mengembangkan Keterampilan Komunikasi: Literature Review
Authors: Safinatunnaja Bq. , Mawaddah Shohipatul 
Published: July 2024

Komunikasi merupakan pusat keberhasilan asuhan pada pasien. Tujuan komunikasi adalah untuk membina hubungan yang baik antara bidan dengan pasien. Bidan harus dibekali keterampilan komunikasi yang baik, agar tercapainya komunikasi dua (2) arah dan meningkatkan kepuasan pasien terhadap pelayanan kebidanan. Tujuan review ini adalah untuk menelaah literatur, artikel dan dokumen hasil penelitian yang mengidentifikasi model pembelajaran pada mahasiswa kebidanan dalam mengembangkan keterampilan komunikasi. Metode penelitian yang digunakan adalah literature review. Hasil dari penelitian yang dianalisisis, didapatkan metode pembelajaran yang digunakan untuk meningkatkan keterampilan komunikasi diantaranya bedside teaching, coaching, Problem Based Learning (PBL), Role Play, drama kreatif, community based medical Education. Metode pembelajaran tersebut berpengaruh terhadap peningkatkan keterampilan komunikasi mahasiswa kebidanan.
Perbandingan Kecepatan Disolusi Intrinsik (Absorpsi) Tablet Asetosal Menggunakan Pelarut Etanol 95% dengan Pelarut Kloroform
Authors: Ariasti Mia , Muhsin Lalu Busyairi , Novitarini Novitarini 
Published: July 2024

Disolusi didefinisikan sebagai proses dimana suatu zat padat masuk ke dalam pelarut menghasilkan suatu larutan secara sederhana. Penelitian ini ertujuan untuk mengetahui kecepatan instrisik suatu sedeiaan tablet. Kecepatan intrisik berpengaruh pada absorpsi tubuh pada tablet obat.Disolusi merupakan proses dimana zat padat melarut secara prinsip dikendalikan oleh afinitas antara zat padat dan pelarut. Karakteristik fisik sediaan, proses pembasahan sediaan kemampuan penetrasi media disolusi ke dalam sediaan, proses pengembangan, proses integrasi dan degadrasi. Sediaan merupakan sebagian dari faktor yang mempengaruhi karakteristik disolusi obat dari sediaan. Uji Disolusi yaitu melakukan rekristalisas asetosal dengan pelarut etanol 95% dan chloroformMencetak hasil rekristalisasi menjadi tablet A (Hasil rekristalisasi dengan pelarut chloroform) dan tablet B (hasil rekristalisasi dengan pelarut etanol 95%).. Sampel ditentukan kadarnya dengan spektrofotometer pada λ= 265 nm dengan blangko dapar asetat. (replikasi 3 kali). Pembuatan kurva baku asetosal dimulai dengan menimbang dengan seksama 140 mg asetosal, melarutkan asetosal dengan alkohol 95% beberapa tetes dalam labu takar 50 ml, menambahkan dapar asetat ada tanda batas (larutan stok). Tablet A 0,319mg/menit.mm, Tablet B 0,182 mg/menit.mm. Terdapat perbedaan antara tablet A dan tablet B pada nilai DE dan kecepatan disolusinya. Dilihat dari efisiensi disolusinya, tablet asetosal dengan pelarut kloroform memiliki nilai DE yang lebih besar daripada tablet asetosal dengan pelarut etanol 95%.
Testing the Antidepressant Activity of Fennel (Foeniculum vulgare Mill) In Vitro Using the Forced Swimming Test (FST) Method
Authors: S. Raisya Hasina , Aini Siti Rahmatul , Pahmi Khairil 
Published: July 2024

Antidepressants are a therapy used for depression sufferers with the aim of reducing symptoms, minimizing side effects and returning them to their original condition. Treatment of depression requires safe and effective therapy to prevent severity. Currently, there are many plants that have potential as antidepressants, such as fennel. The method that can be used to evaluate the effect of antidepressants is the forced swimming test (FST). 24 mice were divided into 8 groups and each group was treated with amitriptyline as a positive control, Na-CMC 0.5% as negative control and fennel infusion as test sample. The data obtained consisted of duration of immobility, climbing, and swimming which was then analyzed using SPSS with the one-way ANOVA test. The results of one-way ANOVA test for immobility, climbing, and swimming time showed that sig. values sequencely are 0.03, 0.006, and 0.016 (P< 0.05). It means that immobility, climbing, and swimming time have significant differences between group of control and treatment.
Valorisation et économie des ressources marines
Authors: Monaco André , Prouzet Patrick 
Published: July 2024

La série Mer et Océan propose une approche interdisciplinaire et intégrée (biologique, physique, chimique) des systèmes océaniques : état et fonctionnement des océans, origine de leur vulnérabilité, scénarios de gestion durable et d’adaptation des sociétés. Une approche qui permet le passage de cette science fondamentale, basée sur l’analyse des processus, leurs couplages à toutes les échelles et entre tous les compartiments, à une science « publique », finalisable et participative, ouverte aux décideurs et aux gestionnaires.Le développement récent des biotechnologies marines, la découverte d’une gigantesque pharmacopée et le développement d’énergies marines renouvelables démontrent que l’homme peut valoriser les biens et services de l’Océan par le biais des technologies nouvelles.Cette mise en valeur des ressources marines nécessite une approche intégrée avec une adaptation non seulement technique, mais aussi sociale et politique afin d’assurer la soutenabilité des filières de production et de minimiser leurs empreintes écologiques.Proposant une analyse du secteur de la pêche et plus largement des activités maritimes, cet ouvrage traite des ressources marines, de leur exploitation, de leur valorisation et des filières économiques qu’elles génèrent sous l’angle des contraintes environnementales croissantes, de la politique de gestion et de l’innovation technique.