bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heteroatom‐Doping Modulates Metal‐Support Interactions in Carbon‐Supported Cobalt Catalysts to Accelerate Polysulfide Redox for Lithium–Sulfur Batteries
Authors: Sun Yinjing , Wang Yingli , Li Caixia , Zhang Qi , Wang Lei , Lv Qingliang , Feng Shouhua 
Published: February 2025

AbstractHigh redox kinetic barriers and the severe shuttle effect of lithium polysulfides (LiPSs) are two primary challenges for the practical deployment of lithium‐sulfur (Li–S) batteries. Herein, highly dispersed Co nanoparticles embedded into S, N co‐doped hollow chained carbon sphere (Co@SNC) are well‐designed and prepared and served as an effective host catalyst for Li–S batteries. Doped S‐atoms can effectively modulate the electronic metal‐support interaction between Co nanoparticles and carbon matrix, which induces charge redistribution and increased d‐orbital energy levels. Co@SNC can provide strong chemical interaction with LiPSs and reduce the Li+ diffusion barrier, which can effectively anchor LiPSs and accelerate the LiPSs conversion kinetics. The hollow chain‐like structure of Co@SNC also synergistically suppresses LiPSs shuttling and enables high sulfur loadings and rapid charge/mass transfer. These merit the Li–S batteries based on Co@SNC with high reversible capacity, impressive rate performance, and prolong cycling stability with a low capacity decay of 0.024% per cycle over 1700 cycles. Notably, the Co@SNC/S electrode still delivers a high initial capacity of 814.9 mAh g−1 and superior cycling performance even at high sulfur loading and poor electrolytes.
Entropy Driving “Quasi‐Zero Strain” Stepwise Multicationic Redox Chemistry Toward a High‐Performance NASICON‐Cathode for Na‐Ion Batteries
Authors: Jin Can , Wang Yao , Zhao Xudong , Jin Junteng , Li Zhenyou , Qu Xuanhui , Jiao Lifang , Liu Yongchang 
Published: February 2025

AbstractAchieving multicationic redox reactions with low lattice strain accumulation upon repeated sodiation/desodiation processes is pivotal for developing high‐energy and long‐durability Na superionic conductor (NASICON)‐type cathodes but still a formidable task. Herein, a novel NASICON‐structured high‐entropy Na3.4VMn0.2Fe0.2Al0.3Cr0.3(PO4)3 (HE‐NVMFACP) cathode is delicately devised, where the entropy‐driving stepwise Fe2+/Fe3+, V3+/V4+/V5+, Mn2+/Mn3+/Mn4+, and Cr3+/Cr4+ redox couples not only trigger the multielectron transfer chemistry, but also alleviate the lattice strain accumulation. Consequently, the HE‐NVMFACP cathode exhibits a high reversible capacity of 151.3 mAh g−1 with an admirable energy density of 520.5 Wh kg−1, and an impressive “quasi‐zero strain” behavior (1.33% cell volume change) during the whole charge‐discharge process. Meanwhile, an excellent rate capability of 90.4 mAh g−1 at 50 C and an ultralong cycling life of 91.9% capacity retention after 5000 cycles are demonstrated. Advanced in situ/ex situ techniques reveal the complete solid‐solution behavior and highly reversible stepwise multicationic redox mechanism of HE‐NVMFACP upon Na+ uptake/release, and the rapid electrode process kinetics of HE‐NVMFACP are confirmed by systematic electrochemical measurements and theoretical computations. Furthermore, the HE‐NVMFACP||hard carbon Na‐ion full batteries are assembled in both coin and pouch configurations, manifesting bright application prospects. The present high‐entropy strategy provides invaluable perspectives for designing high‐energy and long‐life NASICON‐cathodes for sodium‐ion batteries.
Recent Advances in the Preparation of Gallium‐based 2D Materials and Devices Based on Gallium Liquid Metal
Authors: Gao Fangliang , Li Zexi , Li Shuti 
Published: February 2025

AbstractGallium (Ga) liquid metal has become highly suitable for the preparation of 2D materials due to its unique physical and chemical properties, such as high surface tension, low‐melting‐point, and ease of oxidization. Ga has a very low melting point and becomes a silver‐white liquid at 29.76 °C. In the air, the surface of Ga can spontaneously undergo a Cabrera‐Mott oxidation reaction to form an ultra‐thin oxide layer. This self‐formed oxide layer is considered a natural 2D material, and other 2D materials can be derived by post‐processing the oxide layer. In recent years, advancements in surface oxidation techniques for Ga have led to the successful preparation of various Ga‐based 2D materials. These materials possess unique electronic and optical properties along with a simple, low‐cost preparation process, offering broad potential for advancing new electronic devices. This review examines recent research on the preparation of Ga‐based 2D materials derived from Ga and its alloys. It discusses the potential applications of different kinds of Ga‐based 2D devices across multiple fields. Therefore, it can be expected that Ga will play a more significant role in the development of material science in the future.
Control Over Kinetic Self‐Assembly of Phthalocyanine into Photothermal Nano‐Vaccine Enabling Tunable Superlarge Absorption Redshift
Authors: Zhang Shuo , Li Yongxin , Zheng Jilu , Liu Chunlei , Diao Chunyang , Zhao Luyang , Liu Chunzhao 
Published: February 2025

AbstractSupramolecular near‐infrared (NIR) nanomaterials show great application prospects in cancer photothermal immunotherapy. However, the direct self‐assembly of photothermal nanomaterials absorbed in biological transparent window and control over their absorption properties through aggregation behavior remains a grand challenge. Here, the control over superlarge absorption redshift (ranging from 105 nm to 150 nm) of mono‐α‐substituted carboxy zinc phthalocyanine (αZnPc) through kinetic assembly methodologies is demonstrated, resulting in the fabrication of photothermal nanoagents within tissue‐transparent NIR window. Tailoring the solvent polarity allows for the manipulation of kinetic pathways, leading to a variety of self‐assembled structures exhibiting distinct αZnPc macrocycle stacking modes that attribute to their different absorption redshift properties. Mechanistic studies of the relationship between solvent polarity and pathway complexity revealed the energy landscape that governs the unique kinetic behavior. The specific stacking mode and conformation conforming to the charge‐transfer model within these αZnPc assembled structures have been revealed by theoretical calculations. Crucially, the αZnPc nanostructures show remarkable physiological stability and robust photothermal performances within biological transparent window, efficiently ablating primary tumors and triggering immunogenic cell death. This effect is further augmented by the immunomodulatory effects of thymopentin, exhibiting vaccine‐like capabilities in suppressing the growth of distant tumors. This research demonstrates unprecedented levels of control over supramolecular structures and their superlarge red‐shifted absorption, providing great opportunities for future design and construction of supramolecular NIR materials with fascinating properties toward cancer treatments.
Longer Acting Injectable: Continuous, Linear Release of a Progestin Contraceptive From an Oxidized Porous Silicon Host
Authors: Hollett Geoffrey , Fan Ruhan , Kumeria Tushar , Leonard Heidi , Kim Byungji , Martin Taylor R. , Ipekci Irmak , Wang Joanna , Byun Jiuk , Chan Nicole A. , Pierron Amber , Moore Curtis E. , Ayres Jennifer , Sailor Michael J. 
Published: February 2025

AbstractMaintaining stable drug concentrations in the bloodstream is a challenge for injectable hydrophobic progestin contraceptives. This work investigates porous silicon dioxide (pSiO2) microparticles as a delivery vehicle for progestins via melt‐infiltration of drugs into the mesopores. The pSiO2 is prepared through electrochemical anodization of single‐crystalline silicon followed by thermal oxidation, yielding vertically oriented pores (≈50 nm diameter) with porosity varied (between 35–75%) to optimize drug loading and release. Among the progestins tested, etonogestrel and levonorgestrel (LNG) decompose near their melting points, preventing melt infiltration. However, addition of 20% cholesterol by mass suppresses the melting point of LNG sufficiently to enable loading without degradation. Mass loadings exceeding 50% (drug: drug + carrier) are achieved for segesterone acetate (SEG) and LNG, retaining drug crystallinity as confirmed by X‐ray diffraction. In vitro, both SEG and LNG‐loaded pSiO2 display sustained drug release for up to 3 months, with reduced burst release, more constant steady‐state concentrations, and a substantially reduced tail compared to pure LNG or SEG, or SEG loaded into pSiO2 from a chloroform solution. In a pilot in vivo study, SEG‐loaded pSiO2 microparticles are well tolerated in 20‐week‐old female rats over a 25‐week period, with no signs of toxicity.
Two‐Dimensional Cr3Te4/WS2/Fe3GeTe2/WTe2 Magnetic Memory with Field‐Free Switching and Low Power Consumption
Authors: He Kun , Li Bailing , Nie Jianhang , Hou Yanglong , Huan Changmeng , Hong Min , Du Jiantao , Chen Yang , Tang Jingmei , Yi Chen , Feng Ya , Liu Shaojun , Wu Sumei , Liu Miaomiao , Zhang Hongmei , Guo Yukun , Wu Ruixia , Li Jia , Liu Xingqiang , Liu Yuan , Wei Zhongming , Liao Lei , Li Bo , Duan Xidong 
Published: February 2025

AbstractSpin‐orbit torque (SOT) magnetic memory technology has garnered significant attention due to its ability to enable field‐free switching of magnets with strong perpendicular magnetic anisotropy (PMA). However, concerns regarding power consumption of SOT‐memory are persisting. Here, this work proposes a method to construct magnetic tunnel junction (MTJ) by transferring chemically vapor‐deposited two‐dimensional (2D) Cr3Te4/WS2 van der Waals (vdW) heterostructures onto 2D Fe3GeTe2 (FGT) magnet. The robustness and tunability of 2D magnets allow MTJs to exhibit non‐volatility, multiple output states, and impressive cycling durability. MTJs with thin WS2 barriers (fewer than six layers) exhibit a linear tunneling effect, achieving a low resistance‐area product (RA) of 15.5 kΩ·µm2 using bilayer WS2, which facilitats low‐power operation. Furthermore, the different 2D magnets display a significant anti‐parallel window of up to 8 kOe. SOT‐memory based on the typical MTJ demonstrates a low write consumption of 0.3 mJ and read consumption of 9.7 nJ, marking a significant advancement in 2D vdW SOT‐memory. This research has pointed out a new direction for constructing low power consumption SOT‐memory with PMA field‐free switching.
Epithelial Cell Mechanoresponse to Matrix Viscoelasticity and Confinement Within Micropatterned Viscoelastic Hydrogels
Authors: Ciccone Giuseppe , Azevedo Gonzalez‐Oliva Mariana , Versaevel Marie , Cantini Marco , Vassalli Massimo , Salmeron‐Sanchez Manuel , Gabriele Sylvain 
Published: February 2025

AbstractExtracellular matrix (ECM) viscoelasticity has emerged as a potent regulator of physiological and pathological processes, including cancer progression. Spatial confinement within the ECM is also known to influence cell behavior in these contexts. However, the interplay between matrix viscoelasticity and spatial confinement in driving epithelial cell mechanotransduction is not well understood, as it relies on experiments employing purely elastic hydrogels. This work presents an innovative approach to fabricate and micropattern viscoelastic polyacrylamide hydrogels with independently tuneable Young's modulus and stress relaxation, specifically designed to mimic the mechanical properties observed during breast tumor progression, transitioning from a soft dissipative tissue to a stiff elastic one. Using this platform, this work demonstrates that matrix viscoelasticity differentially modulates breast epithelial cell spreading, adhesion, YAP nuclear import and cell migration, depending on the initial stiffness of the matrix. Furthermore, by imposing spatial confinement through micropatterning, this work demonstrates that confinement alters cellular responses to viscoelasticity, including cell spreading, mechanotransduction and migration. These findings establish ECM viscoelasticity as a key regulator of epithelial cell mechanoresponse and highlight the critical role of spatial confinement in soft, dissipative ECMs, which was a previously unexplored aspect.
Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF‐1 Pathway in Polycystic Ovary Syndrome
Authors: Wang Guiquan , Mao Weian , Zhang Yurong , Yang Haiyan , Zhu Ming , Li Yan , Chen Wei , Chen Yi , Lou Chen , Li Ping , Chang Hsun‐Ming , Yuan Shuai , Zhao Yue , Mu Liangshan 
Published: February 2025

AbstractPolycystic ovary syndrome (PCOS) affects reproductive and cardiometabolic health, yet its pathogenesis remains unclear. Emerging evidence links hemoglobin levels to metabolic disorders, suggesting a potential role in PCOS development. Here, we integrated a large‐scale cohort study, Mendelian randomization (A genetic tool to infer causal relationships), bioinformatics analyses, and in vitro experiments to investigate the relationship between hemoglobin levels and PCOS. In a cohort of 20 602 women, each 10 g L−1 elevation in hemoglobin levels is associated with 22% higher odds of PCOS (adjusted odds ratio: 1.22, 95% confidence interval: 1.15–1.29, P < 0.001) and PCOS manifestations, particularly hyperandrogenism. Mendelian randomization analysis confirms that higher hemoglobin levels are associated with increased PCOS risk and elevated testosterone levels. The hypoxia‐inducible factor 1 (HIF‐1) pathway is enriched, identifying three testosterone‐associated genes (nuclear factor kappa B (NFKB1), insulin receptor (INSR), protein kinase C alpha. Colocalization and druggability analysis supports shared genetic regions and confirmed these genes as druggable targets. Upregulation of NFKB1 and INSR are confirmed in both blood and ovarian granulosa cells of PCOS patients. The findings demonstrate that higher‐end normal hemoglobin levels are associated with increased PCOS risk, potentially through a mechanism of elevating testosterone levels involving the HIF‐1 pathway.
LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer
Authors: Zhang Qi , Wang Xuliren , Shao Zhibo , Zhang Yi , Zhang Liyi , Chen Ming , Zhou Xujie , Zhu Han , Zhou Yue , Lu Xinya , Li Pei , Chi Weiru , Li Lun , Shao Zhi‐Ming , Huang Shenglin , Xue Jingyan , Chi Yayun , Wu Jiong , Xiu Bingqiu 
Published: February 2025

AbstractDespite the development of HER2‐targeting drugs such as trastuzumab and T‐DXd, treatment resistance is a substantial challenge, often leading to relapse and distant metastasis. Tumor heterogeneity in HER2‐positive breast cancer drives the evolution of resistant clones following therapeutic stress. However, the targetable drivers of anti‐HER2 treatment resistance are not thoroughly identified. This study aims to use neoadjuvant‐targeted therapy cohorts and a patient‐derived organoid in vitro treatment model to uncover the potential targetable drivers of anti‐HER2 treatment resistance. it is found that LINC01235 significantly enhances DNA replication licensing and chromosomal instability, fostering clonal expansion and evolution, and ultimately increasing resistance to therapeutic interventions. LINC01235 regulates global H3K27ac, H3K9ac, and H3K36me3 modifications, promotes H2A.Z expression in regulatory regions, and increases the accessibility of DNA licensing factors to their promoter regions. XRCC5 is identified as a key component for maintaining genomic stability, crucial for LINC01235's role in replication licensing. Furthermore, therapeutic strategies targeting LINC01235, including the use of antisense oligonucleotides or ATR inhibitors, which showed promise in overcoming treatment resistance are explored. These findings underscore the pivotal role of LINC01235 in driving resistance mechanisms and highlight novel avenues for targeted therapies to improve the outcomes of patients with HER2‐positive breast cancer.
Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti‐Tumor Efficiency Based on a Functional Iridium(III) Complex
Authors: Pei Yu , Pan Yinzhen , Zhang Zhijun , Zhu Jun , Sun Yan , Zhang Qian , Zhu Dongxia , Li Guangzhe , Bryce Martin R. , Wang Dong , Tang Ben Zhong 
Published: February 2025

AbstractThe tumor microenvironment (TME) severely limits the efficacy of clinical applications of photodynamic therapy (PDT). The development of a functional agent allowing full use of the TME to boost synergistic PDT and ferroptosis anti‐tumor efficiency is an appealing yet significantly challenging task. Herein, to overcome the adverse influence on PDT of hypoxia and high level of glutathione (GSH) in the TME, an imine bond is introduced into an Ir(III)‐ferrocene complex to construct a small molecule drug, named Ir‐Fc, for tumors’ imaging and therapy. The cleavage of the imine bond in the lysosome effectively disrupts the photoinduced electron transfer (PET) process, realizing the decomposition of Ir‐Fc into Fc‐CHO and Ir‐NH2. Fc‐CHO produces •OH by Fenton reactions under dark conditions and induces ferroptosis in tumor cells, and Ir‐NH2 shows prominent performance for type‐I and type‐II reactive oxygen species (ROS) production. Meanwhile, the ferroptosis pathway simultaneously consumes large amounts of GSH and produces O2 for effectively relieving hypoxia. These distinctive outputs make Ir‐Fc an exceptional molecule for effective tumor synergistic therapy. This study thus brings a new and revolutionary PDT protocol for practical cancer treatment.
Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA‐Seq and Stereo‐Seq, with Insights into SOX3's Role in Pituitary Development
Authors: Wang Shengjie , Jiang Deyue , Xiao Yan , Qin Qiaozhen , Zhang Heyang , Ye Lingtong , Jin Jide , Jiang Xiaoxia , Guo Qinghua 
Published: February 2025

AbstractThe 3D human pituitary organoid represents a promising laboratory model for investigating human pituitary diseases. Nonetheless, this technology is still in its nascent stage, with uncertainties regarding the cellular composition, intercellular interactions, and spatial distribution of the human pituitary organoids. To address these gaps, the culture conditions are systematically adjusted and the efficiency of induced pluripotent stem cells’ (iPSCs’) differentiation into pituitary organoids is successfully improved, achieving results comparable to or exceeding those of previous studies. Additionally, single‐cell RNA‐sequencing (scRNA‐seq) and stereomics sequencing (Stereo‐seq) are performed on the pituitary organoids for the first time, and unveil the diverse cell clusters, intricate intercellular interactions, and spatial information within the organoids. Furthermore, the SOX3 gene interference impedes the iPSCs’ differentiation into pituitary organoids, thereby highlighting the potential of pituitary organoids as an ideal experimental model. Altogether, the research provides an optimized protocol for the human pituitary organoid culture and a valuable transcriptomic dataset for future explorations, laying the foundation for subsequent research in the field of pituitary organoids or pituitary diseases.
Tailoring Piezoelectric Nanogenerators and Microdevices for Cellular Excitation: Impact of Size and Morphology
Authors: Lefaix Laura , Navarro Marc , Nogués Carme , Blanquer Andreu , Murillo Gonzalo 
Published: February 2025

AbstractThe use of piezoelectric devices as wireless electrical stimulators is an emerging research topic. In this study, piezoelectric microdevices, consisting of ZnO nanosheets (NSs) functioning as piezoelectric nanogenerators (NGs) grown on top of silicon microparticles, to electrically stimulate cell are designed. The morphology of the ZnO NSs is optimized by tuning the thickness of the aluminum nitride (AlN) catalyst layer and adjusting the growth duration. ZnO NSs grown on thinner AlN layers (≤ 200 nm) and subjected to 9 h of hydrothermal growth exhibit the most suitable characteristics for cell stimulation, balancing crystal size, and electric field generation. The generation of a local electric field capable of exciting osteoblast cells is inferred from finite element simulations and intracellular calcium influx measurements. The internalization rate of silicon microdevices of varying sizes (3 × 3, 6 × 10, 12 × 18 µm2) by osteosarcoma (Saos‐2) and primary human osteoblast (hOB) cells.is assessed The results show that smaller devices have higher internalization rates, particularly in tumoral Saos‐2 cells, while primary cells exhibit minimal internalization (< 10%) across all particle sizes. This study presents an optimized piezoelectric microdevice, based on a scalable and customizable fabrication process, for minimally invasive bioelectronic applications, offering accurate electrical cell stimulation while minimizing unwanted internalization.
Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management
Authors: Yang Juwei , Li Longfei , Hu Yiran , Li Zhou , Hua Wei 
Published: February 2025

AbstractElectroactive platforms have gained significant attention for their ability to convert various types of energy into electrical signals, offering promising applications in diverse biomedical fields. In cardiovascular care, these platforms are increasingly valued for their innovative solutions in managing cardiac functions and disorders. By regulating electrical activity in the heart, electroactive platforms offer novel methods for managing abnormal heart rhythms. This review explores the latest advancements in electroactive systems, categorizing them based on their energy sources and mechanisms, such as self‐powered and conductive systems. It also highlights their applications in arrhythmia management, including monitoring, intervention, pacing, and repairing. Finally, the challenges, limitations, and future opportunities for clinical translation of these technologies are discussed.
Ultrasonography guided modified Sellick manoeuvre in post‐oesophagectomy patients – a case series*
Authors: Reddivari N. , Naik V. , Rayani B. K. , Adda S. 
Published: February 2025

SummaryOesophagectomy is an established treatment option for the management of oesophageal carcinoma. This procedure results in loss of the lower oesophageal sphincter, which increases the risk of pulmonary aspiration in patients presenting for subsequent surgeries. Consequently, innovative strategies are needed to enhance safety during airway management. Although Sellick manoeuvre (cricoid pressure) is commonly used to mitigate the risk of aspiration, there is limited evidence to support its efficacy. Additionally, cricoid pressure may not be effective in patients who have undergone oesophagectomy because of the altered neck anatomy. In this case series, we present seven post‐oesophagectomy patients who underwent ultrasound‐guided modified Sellick manoeuvre for airway management. During tracheal intubation with a videolaryngoscope, the gastric conduit in the neck was visualised and compressed with the ultrasound probe, attempting to oppose both walls of the conduit and reduce the risk of regurgitation. This approach addresses the challenges posed by altered anatomy and the limitations of traditional cricoid pressure, potentially enhancing the safety of airway management in these patients. While ultrasound‐guided oesophageal compression shows promise as a feasible technique, further studies are needed to validate its effectiveness.