bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of accounting in supporting adaptation to climate change
Authors: Linnenluecke Martina K. , Birt Jacqueline , Griffiths Andrew 
Published: April 2015

AbstractThe study is one of the first concerned with the topic of accounting and climate change adaptation. It proposes that the accounting role can support organisational climate change adaptation by performing the following functions: (i) a risk assessment function (assessing vulnerability and adaptive capacity), (ii) a valuation function (valuing adaptation costs and benefits) and (iii) a disclosure function (disclosure of risk associated with climate change impacts). This study synthesises and expands on existing research and practice in environmental accounting and sets the scene for future research and practice in the emerging area of accounting for climate risk.
Testing the effect of portfolio holdings disclosure in an environment absent of mandatory disclosure
Authors: Chen Zhe , Gallagher David R. , Lee Adrian D. 
Published: April 2015

AbstractThis study examines a number of portfolio disclosure regimes with respect to accuracy and susceptibility to copycat behaviour in an environment absent of mandatory disclosure. We find that periodic portfolio disclosure tends to underestimate true excess performance as well as idiosyncratic risk in top‐quartile fund managers, with longer inter‐reporting intervals tending to result in greater differences. ‘Copycat funds’ following the disclosed holdings of top‐tier managers significantly underperform the underlying fund, while copycats following bottom‐tier managers significantly outperform the underlying fund. Our findings suggest that periodic reporting at monthly intervals or longer would not affect fund alpha generation.
Effectiveness of a selective intervention program targeting personality risk factors for alcohol misuse among young adolescents: results of a cluster randomized controlled trial
Authors: Lammers Jeroen , Goossens Ferry , Conrod Patricia , Engels Rutger , Wiers Reinout W. , Kleinjan Marloes 
Published: April 2015

AbstractAimThe effectiveness of Preventure was tested on drinking behaviour of young adolescents in secondary education in the Netherlands.DesignA cluster randomized controlled trial was carried out, with participants assigned randomly to a two‐session coping skills intervention or a control no‐intervention condition.SettingFifteen secondary schools throughout the Netherlands; seven schools in the intervention and eight schools in the control condition.ParticipantsA total of 699 adolescents aged 13–15 years participated, 343 allocated to the intervention and 356 to the control condition, with drinking experience and elevated scores in either negative thinking, anxiety sensitivity, impulsivity or sensation‐seeking.Intervention and comparatorPreventure is a selective school‐based alcohol prevention programme targeting personality risk factors. The comparator was a no‐intervention control.MeasurementsThe effects of the intervention on the primary outcome past‐month binge drinking, and the secondary outcomes binge drinking frequency, alcohol use, alcohol frequency and problem drinking, were examined. The primary analyses of interest were intervention main effects at 12 months post‐intervention. In addition, intervention effects on the linear development of binge drinking using a latent‐growth curve approach were examined.FindingsBinge drinking rates were not significantly different between the intervention (42.9%) and control group (49.2%) at 12 months follow‐up [odds ratio (OR) = 1.05, confidence interval (CI) = 0.99, 1.11]. Intention‐to‐treat analyses revealed no significant intervention effects on alcohol use (53.9 versus 61.5%; OR = 0.99, CI = 0.86, 1.14) and problem drinking (37.0 versus 44.7%; OR = 1.03, CI = 0.92, 1.10) at 12 months follow‐up. The post‐hoc latent‐growth analyses revealed significant effects on the development of binge drinking (β = –0.16, P = 0.05), and binge drinking frequency (β = –0.14, P = 0.05).ConclusionThe alcohol prevention programme, Preventure, appears to have little or no effect on overall prevalence of binge drinking in adolescents in the Netherlands but may reduce the development of binge drinking over time.
Curriculum development for a national cardiotocography education program: a Delphi survey to obtain consensus on learning objectives
Authors: Thellesen Line , Hedegaard Morten , Bergholt Thomas , Colov Nina P. , Hoegh Stinne , Sorensen Jette L. 
Published: April 2015

AbstractObjectiveTo define learning objectives for a national cardiotocography (CTG) education program based on expert consensus.DesignA three‐round Delphi survey.Population and settingOne midwife and one obstetrician from each maternity unit in Denmark were appointed based on CTG teaching experience and clinical obstetric experience.MethodsFollowing national and international guidelines, the research group determined six topics as important when using CTG: fetal physiology, equipment, indication, interpretation, clinical management, and communication/responsibility. In the first Delphi round, participants listed one to five learning objectives within the predefined topics. Responses were analyzed by a directed approach to content analysis. Phrasing was modified in accordance with Bloom's taxonomy. In the second and third Delphi rounds, participants rated each objective on a five‐point relevance scale. Consensus was predefined as objectives with a mean rating value of ≥3.Main outcome measuresA prioritized list of CTG learning objectives.ResultsA total of 42 midwives and obstetricians from 21 maternity units were invited to participate, of whom 26 completed all three Delphi rounds, representing 18 maternity units. The final prioritized list included 40 objectives. The highest ranked objectives emphasized CTG interpretation and clinical management. The lowest ranked objectives emphasized fetal physiology. Mean ratings of relevance ranged from 3.15 to 5.00.ConclusionsNational consensus on CTG learning objectives was achieved using the Delphi methodology. This was an initial step in developing a valid CTG education program. A prioritized list of objectives will clarify which topics to emphasize in a CTG education program.
Prognostic Significance of 1‐Year Serum Albumin Levels Within the Normal Range After Kidney Transplantation
Authors: Oh Il Hwan , Park Joon‐Sung , Lee Chang Hwa , Kang Chong Myung , Kim Gheun‐Ho 
Published: April 2015

AbstractHypoalbuminemia is associated with poor outcomes in kidney transplantation (KT). However, what level is optimal in serum albumin is not clear for the long‐term prognosis. To determine whether the long‐term outcomes are different even between the normal ranges of serum albumin after KT, we analyzed data from 404 renal allograft recipients whose 1‐year post‐transplant serum albumin levels were within the normal limits (3.5–5.5 g/dL). During a follow‐up of 122 ± 56 months, 97 graft losses, 20 patient deaths, and 50 cardiovascular (CV) events occurred. Based on 1‐year serum albumin levels, the patients were divided into high normal (≥4.6 g/dL, n = 209) and low normal (<4.6 g/dL, n = 195) groups. Kaplan–Meier analyses revealed that the low normal group had poorer allograft survival (P = 0.01), patient survival (P < 0.001), and CV event‐free survival (P < 0.001) than the high normal group. Cox regression analysis confirmed that 1‐year serum albumin was inversely associated with the risk of graft loss (hazard ratio [HR] 0.414, 95% confidence interval [CI] 0.200–0.856), patient death (HR 0.097, 95% CI 0.019–0.484), and CV events (HR 0.228, 95% CI 0.074–0.702). In conclusion, a relatively low 1‐year post‐transplant serum albumin level within the normal limits (<4.6 g/dL) significantly predicts poor long‐term outcomes.
Simulated Prosthetic Vision: The Benefits of Computer‐Based Object Recognition and Localization
Authors: Macé Marc J.‐M. , Guivarch Valérian , Denis Grégoire , Jouffrais Christophe 
Published: April 2015

AbstractClinical trials with blind patients implanted with a visual neuroprosthesis showed that even the simplest tasks were difficult to perform with the limited vision restored with current implants. Simulated prosthetic vision (SPV) is a powerful tool to investigate the putative functions of the upcoming generations of visual neuroprostheses. Recent studies based on SPV showed that several generations of implants will be required before usable vision is restored. However, none of these studies relied on advanced image processing. High‐level image processing could significantly reduce the amount of information required to perform visual tasks and help restore visuomotor behaviors, even with current low‐resolution implants. In this study, we simulated a prosthetic vision device based on object localization in the scene. We evaluated the usability of this device for object recognition, localization, and reaching. We showed that a very low number of electrodes (e.g., nine) are sufficient to restore visually guided reaching movements with fair timing (10 s) and high accuracy. In addition, performance, both in terms of accuracy and speed, was comparable with 9 and 100 electrodes. Extraction of high level information (object recognition and localization) from video images could drastically enhance the usability of current visual neuroprosthesis. We suggest that this method—that is, localization of targets of interest in the scene—may restore various visuomotor behaviors. This method could prove functional on current low‐resolution implants. The main limitation resides in the reliability of the vision algorithms, which are improving rapidly.
Pharmacokinetics and safety of subcutaneous rituximab plus fludarabine and cyclophosphamide for patients with chronic lymphocytic leukaemia
Authors: Assouline Sarit , Buccheri Valeria , Delmer Alain , Gaidano Gianluca , McIntyre Christine , Brewster Michael , Catalani Olivier , Hourcade‐Potelleret Florence , Sayyed Pakeeza , Badoux Xavier 
Published: April 2015

AimsThe aim of the phase Ib, two part SAWYER study (BO25341; NCT01292603) was to investigate the pharmacokinetics and safety of subcutaneous (s.c.) rituximab compared with intravenous (i.v.) rituximab, both in combination with fludarabine and cyclophosphamide (FC), as first line treatment for patients with chronic lymphocytic leukaemia (CLL).MethodsDuring part 1 (dose‐finding), CLL patients received rituximab i.v. followed by a single dose of rituximab s.c. at one of three fixed doses (1400, 1600 or 1870 mg) in cycle 6. The primary objective was to identify a fixed s.c. dose that would achieve comparable rituximab serum trough concentrations (Ctrough) to those achieved with the standard 4 weekly 500 mg m–2 rituximab i.v. dose.ResultsFifty‐five patients received a fixed dose of rituximab s.c., 16 received 1400 mg, 17 received 1600 mg and 22 received 1870 mg. The 1600 mg dose was predicted to achieve non‐inferior Ctrough to standard rituximab i.v. treatment. The rituximab s.c. safety profile was comparable with rituximab i.v., except that local administration‐related reactions, mainly mild/moderate injection site reactions, occurred more frequently with rituximab s.c., which was not unexpected. Subcutaneous administration was preferred to i.v. administration by >90% of patients and nurses (n = 112).ConclusionsSAWYER part 1 data predict that rituximab s.c. 1600 mg will achieve non‐inferior Ctrough concentrations to rituximab i.v. 500 mg m–2, administered 4 weekly. This fixed s.c. dose is currently undergoing formal non‐inferiority assessment in SAWYER part 2. In future, CLL treatment regimens comprising rituximab s.c. and oral FC could substantially reduce i.v. chair time.
Exploring TED talks as linked data for education
Authors: Taibi Davide , Chawla Saniya , Dietze Stefan , Marenzi Ivana , Fetahu Besnik 
Published: April 2015

AbstractIn this paper, we present the TED Talks dataset which exposes all metadata and the actual transcripts of available TED talks as structured Linked Data. The TED talks collection is composed of more than 1800 talks, along with 35 000 transcripts in over 30 languages, related to a wide range of topics. In this regard, TED talks metadata available in structured, multilingual and HTTP‐accessible form constitute a valuable resource, for instance, for schoolteachers, to explore controversial contemporary topics with their students in order to stimulate awareness and critical thinking or as a means for language learning. Moreover, being compliant with state‐of‐the‐art Linked Data principles, our dataset facilitates the computation of links with related data and resources. The TED dataset is used by a number of educational applications, and it is included in the LinkedUp Data Catalog.
Romidepsin in peripheral and cutaneous T‐cell lymphoma: mechanistic implications from clinical and correlative data
Authors: Bates Susan E. , Eisch Robin , Ling Alexander , Rosing Douglas , Turner Maria , Pittaluga Stefania , Prince H. Miles , Kirschbaum Mark H. , Allen Steven L. , Zain Jasmine , Geskin Larisa J. , Joske David , Popplewell Leslie , Cowen Edward W. , Jaffe Elaine S. , Nichols Jean , Kennedy Sally , Steinberg Seth M. , Liewehr David J. , Showe Louise C. , Steakley Caryn , Wright John , Fojo Tito , Litman Thomas , Piekarz Richard L. 
Published: April 2015

SummaryRomidepsin is an epigenetic agent approved for the treatment of patients with cutaneous or peripheral T‐cell lymphoma (CTCL and PTCL). Here we report data in all patients treated on the National Cancer Institute 1312 trial, demonstrating long‐term disease control and the ability to retreat patients relapsing off‐therapy. In all, 84 patients with CTCL and 47 with PTCL were enrolled. Responses occurred early, were clinically meaningful and of very long duration in some cases. Notably, patients with PTCL receiving romidepsin as third‐line therapy or later had a comparable response rate (32%) of similar duration as the total population (38%). Eight patients had treatment breaks of 3·5 months to 10 years; in four of six patients, re‐initiation of treatment led to clear benefit. Safety data show slightly greater haematological and constitutional toxicity in PTCL. cDNA microarray studies show unique individual gene expression profiles, minimal overlap between patients, and both induction and repression of gene expression that reversed within 24 h. These data argue against cell death occurring as a result of an epigenetics‐mediated gene induction programme. Together this work supports the safety and activity of romidepsin in T‐cell lymphoma, but suggests a complex mechanism of action.
Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics
Authors: Falini Brunangelo , Sportoletti Paolo , Brunetti Lorenzo , Martelli Maria Paola 
Published: April 2015

SummaryThe acute myeloid leukaemia (AML) genome contains more than 20 driver recurrent mutations. Here, we review the potential for therapeutic targeting of the most common mutations associated with normal cytogenetics AML, focusing on those affecting the FLT3, NPM1 and epigenetic modifier genes (DNMT3A, IDH1/2, TET2). As compared to early compounds, second generation FLT3 inhibitors are more specific and have better pharmacokinetics. They also show higher anti‐leukaemic activity, leading to about 50% of composite complete remissions in refractory/relapsed FLT3‐internal tandem duplication‐mutated AML. However, rapid relapses invariably occur due to various mechanisms of resistance to FLT3 inhibitors. This issue and the best way for using FLT3 inhibitors in combination with other therapeutic modalities are discussed. Potential approaches for therapeutic targeting of NPM1‐mutated AML include: (i) reverting the aberrant nuclear export of NPM1 mutant using exportin‐1 inhibitors; (ii) disruption of the nucleolus with drugs blocking the oligomerization of wild‐type nucleophosmin or inducing nucleolar stress; and (iii) immunotherapeutic targeting of highly expressed CD33 and IL3RA (CD123) antigens. Finally, we discuss the role of demethylating agents (decitabine and azacitidine) and IDH1/2 inhibitors in the treatment of AML patients carrying mutations of genes (DNMT3A, IDH1/2 and TET2) involved in the epigenetic regulation of transcription.
Changing paradigms in the management of deep vein thrombosis
Authors: Lang Kathryn J. , Saha Prakash , Roberts Lara N. , Arya Roopen 
Published: April 2015

SummaryIn adults diagnosed with deep vein thrombosis (DVT), challenges remain in the management of the acute event whilst remaining alert to long‐term morbidity. The addition of non‐vitamin K antagonist oral anticoagulants (NOACs) to the pharmacopoeia represents the first of a number of recent advancements in the management of DVT. Worldwide, uptake of these agents has been avid, although drug selection, reversal and chronic treatment effects continue to be controversial areas. Multi‐centre studies to evaluate the impact of NOACs on long‐term outcomes, including thrombosis recurrence and post‐thrombotic syndrome (PTS), are ongoing. Validation of tools capable of predicting PTS would enable patient selection for early aggressive intervention, such as local thrombolysis. Such interventional strategies are gaining momentum as initial approaches and would benefit from large randomized controlled trials.
Follow‐up of the neuro‐urological patient: a systematic review
Authors: Averbeck Marcio Augusto , Madersbacher Helmut 
Published: April 2015

ObjectivesTo systematically review the long‐term urological follow‐up strategies for patients with neurogenic lower urinary tract dysfunction (NLUTD), focusing on three main groups of neurological diseases: (i) spinal cord injuries, (ii) spinal dysraphism, and (iii) multiple sclerosis.Patients and MethodsData acquisition comprised electronic search on the Medical Literature Analysis and Retrieval System Online (MEDLINE) database and the EMBASE database in August 2014 to retrieve English language studies. MEDLINE and EMBASE search included the following medical subject heading (MeSH) terms: (i) neurogenic bladder and (ii) neurogenic bladder dysfunction. Each of these terms was crossed with (i) long‐term care and (ii) long‐term surveillance. Only studies related to NLUTD and urological follow‐up were included. Studies were also identified by hand search of reference lists and review articles.ResultsInitial records identified through database searching included 265 articles. In all, 23 articles were included in the quantitative synthesis. The proposed time schedule of investigations as well as the amount and type of investigation were different according to specific neurological lesions. They depend on the dysfunctional pattern of the lower urinary tract (LUT) and its risk profile. However, there is a lack of high‐evidence level studies to support an optimal long‐term follow‐up protocol.ConclusionsThe goal of neuro‐urological management is the best possible preservation of upper urinary tract (UUT) and LUT function in relation to the individual neurological disorder. Regular and risk adapted controls (‘urochecks’) allow detection of risk‐factors in time before irreversible changes of the LUT and UUT have occurred. With risk‐ and patient‐oriented lifelong regular urological care an optimised quality of life and life‐expectancy can be achieved, although there is a complete lack of high‐evidence level studies on this topic.
Volatilité dans l'utilisation des indicateurs de performance municipale : Bilan et nouvelle perspective d'analyse
Authors: Charbonneau Étienne , Divay Gérard , Gardey Damien 
Published: April 2015

SommaireLes indicateurs de performance municipale font l'objet d'un intérêt renouvelé par les provinces et villes canadiennes, comme dans plusieurs autres pays. À partir d'une revue des études publiées, cet essai enrichit la littérature sur deux points. Il établit un bilan des connaissances sur leur utilisation qui prend en compte la diversité des types d'indicateurs. Il propose aussi un cadre d'analyse de l'interface politico‐administrative locale qui aide à comprendre la variabilité et la volatilité dans l'utilisation de divers types d'indicateurs. Cette nouvelle perspective permet de mieux comprendre pourquoi l'utilisation des indicateurs de performance par les élus et administrateurs est limitée.
The goal of making friends for youth with disabilities: creating a goal menu
Authors: Gerhardt S. , McCallum A. , McDougall C. , Keenan S. , Rigby P. 
Published: April 2015

AbstractBackgroundClinicians working with youth with disabilities have acknowledged making friends as a commonly identified client goal. Clinicians find this goal difficult to address, as there are no measures that provide a breakdown of making friends into functional steps. In addition, research on friendship has traditionally focused on characteristics and quality of friendships rather than the friend‐making process as a whole. A goal menu, comprised of a variety of steps that address the goal of making friends, would provide guidance to clinicians challenged with this goal in practice.PurposeTo develop an understanding of the friend‐making process as a first step towards the development of a goal menu for the goal of making friends.MethodsA literature review, youth focus group and expert clinician semi‐structured interviews and consultation were used to generate a comprehensive data set. Established qualitative methods were used to sort and group the data into categories. A thematic analysis of the categories was performed.ResultsAnalysis revealed four themes integral to the friend‐making process: person factors influencing friend‐making, making friend‐making a priority, opportunity for friend‐making and motivation to make friends. An additional theme identified as occasionally involved in the process was a little bit of luck in making friends.ConclusionsThe themes generated by this research indicate that actionable target areas exist for the somewhat abstract notion of friend‐making and the authors recommend that clinicians explore beyond person factors when addressing the goal of making friends. As a next step, the identified themes will provide the foundation for a goal menu, ultimately enabling clinicians to address the goal of making friends in a more efficient and effective manner.
Correlates of physical activity behaviours in young Iranian girls
Authors: Khodaverdi Z. , Bahram A. , Robinson L. E. 
Published: April 2015

AbstractBackgroundThis study examined the relationship among motor skill competence, perceived motor competence (PMC), health‐related physical fitness and physical activity in 8–9‐year‐old Iranian girls (n = 352).MethodsLocomotor and object control motor skill competence was assessed using the Test of Gross Motor Development – 2nd edition. PMC was assessed using the Physical Ability subscale of Marsh's Self‐Description Questionnaire‐1. Health‐related physical fitness was measured with body mass index, the 600 yard run/walk, curl‐ups, push‐ups, and back‐saver sit and reach tests. Children's physical activity was assessed using the Physical Activity Questionnaire for Older Children.ResultsRegression analysis revealed that locomotor proficiency, aerobic fitness and PMC accounted for 56% (P < .001) of variance associated with moderate‐to‐vigorous physical activity.ConclusionThe findings warrant future investigations that examine interventions that focus on motor skill and perceived competence along with aerobic fitness to promote physical activity in girls.