bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic repair of a Bochdalek hernia in an adult woman
Authors: Sutedja Barlian , Muliani Yenny 
Published: August 2015

AbstractBochdalek hernia (BH) is a congenital defect of the diaphragm that usually presents in the neonatal period with life threatening cardiorespiratory distress. It is rare for BH to remain silent until adulthood. A 51‐year‐old woman presented with progressive dyspnea and abdominal symptoms, but without a history of trauma. The diagnosis of BH was made based on chest X‐ray and CT. The hernia was repaired by the laparoscopic technique, and the patient made an uneventful recovery. This report validates the feasibility of laparoscopic repair of BH in an adult, which should be within the capability of an advanced laparoscopic surgeon.
Urgent laparoscopic mesh splenopexy for torsion of wandering spleen and distal pancreas: A case report
Authors: Torri Fabio , Parolini Filippo , Vanzetti Enrico , Milianti Susanna , Cheli Maurizio , Alberti Daniele 
Published: August 2015

AbstractWandering spleen is a condition in which an incomplete fusion of the splenic ligaments allows the spleen to move within the abdomen, predisposing it to splenic torsion along its vascular pedicle. Torsion of a wandering spleen is an uncommon occurrence, especially in children, and associated torsion of the distal pancreas is even more unusual, with only four cases having been reported in adults. Non‐specific clinical presentation makes radiologic evaluation essential in order to obtain a diagnosis and to send the patient for early surgery before life‐threatening complications arise. Here we present a rare case of torsion of wandering spleen together with volvulus of the distal pancreas in a 13‐year‐old girl. In this case, prompt radiological assessment allowed for an early diagnosis, and the patient was successfully treated with urgent laparoscopic derotation of both the spleen and the distal pancreas as well as mesh splenopexy. To the best of our knowledge, this procedure has never been described in a pediatric setting.
Laparoscopic surgery for sigmoidocutaneous fistula due to diverticulitis: A case report
Authors: Hidaka Eiji , Nakahara Kenta , Maeda Chiyo , Takehara Yusuke , Ishida Fumio , Kudo Shin‐ei 
Published: August 2015

AbstractSigmoidocutaneous fistulas due to sigmoid colon diverticulitis are very rare. Here we report a case in which laparoscopic sigmoidectomy was used to successfully treat a sigmoidocutaneous fistula due to diverticulitis. A 41‐year‐old man was admitted to our hospital because of redness and swelling of the left inguinal skin. Enhanced abdominal CT revealed a subcutaneous abscess in the left lower abdomen. Percutaneous drainage was performed, and fistulography revealed a fistula between the sigmoid colon and left inguinal skin. Therefore, a sigmoidocutaneous fistula was diagnosed, and laparoscopic sigmoidectomy and fistulectomy were performed. The sigmoid colon had several diverticula, and a pathological examination revealed that the sigmoidocutaneous fistula was due to diverticulitis. The postoperative course was uneventful, and the patient was discharged on postoperative day 8. In cases of sigmoidocutaneous fistula, laparoscopic treatment can be safely performed.
Retroperitoneal schwannoma between the inferior vena cava and the abdominal aorta resected by laparoscopic surgery: A case report
Authors: Nishizawa Nobuyuki , Kumamoto Yusuke , Hirata Mitsuhiro , Watanabe Masahiko 
Published: August 2015

AbstractA 22‐year‐old woman presented with backache. Imaging analysis revealed a retroperitoneal tumor, 40 mm in diameter, surrounded by the abdominal aorta, inferior vena cava, caudate lobe of liver, and the left renal vein. The tumor consisted of multilocular cystic parts, and a solid part showed contrast enhancement. The possibility of malignancy could not be excluded, so we planned a laparoscopic tumorectomy. After placement of a transjugular vascular sheath for an occlusion balloon catheter in the inferior vena cava, the operation was performed with six ports. There was a strong fibrotic adhesion between the tumor and the abdominal aorta, with other weak adhesions. The tumor was successfully resected by a laparoscopic operation with minimal bleeding. The histopathological diagnosis was a benign schwannoma. This case demonstrates that a retroperitoneal tumor adjacent to major vessels can be resected safely by laparoscopic surgery if the surgeon is especially careful of the possibility of accidental bleeding.
Laparoscopic anterior pelvic exenteration for locoregionally advanced rectal cancer directly invading the urinary bladder: A case report of low anterior resection with en bloc cystectomy for sphincter preservation
Authors: Ishizaki Hidenobu , Nakashima Shinya , Hamada Takeomi , Nishida Takahiro , Maehara Naoki , Ikeda Takuto , Tsukino Hiromasa , Mukai Shoichiro , Kamoto Toshiyuki , Kondo Kazuhiro 
Published: August 2015

AbstractLaparoscopic multi‐visceral resection in patients with T4 colorectal cancer remains controversial. A 73‐year‐old man was admitted to the hospital for rectosigmoid cancer directly invading the urinary bladder trigone without distant metastasis. We successfully performed complete resection by laparoscopic anterior pelvic exenteration while preserving the anus. After laparoscopic mobilization of the rectum, urinary bladder, and prostate, the urethra and urethral catheter were dissected to reveal the lower rectum. By pulling the urethral catheter toward the head, the prostate was excised retrogradely from the lower rectum anterior wall. The lower rectum was resected and anastomosed by the double stapling technique with a safe distal margin from the tumor. Pathological findings of the resected specimen indicated no residual tumor in the surgical margin. There was no evidence of recurrence 34 months after surgery. En bloc, R0, laparoscopic anterior pelvic exenteration for T4 rectal cancer is feasible. However, further studies with long‐term follow‐up are required to resolve oncological outcomes.
Improving transport container design to reduce broiler chicken PSE (pale, soft, exudative) meat in Brazil
Authors: Spurio Rafael S. , Soares Adriana L. , Carvalho Rafael H. , Silveira Junior Vivaldo , Grespan Moisés , Oba Alexandre , Shimokomaki Massami 
Published: August 2015

AbstractThroughout the chicken production chain, transport from farm to the commercial abattoir is one of the most critical sources of stress, particularly heat stress. The aim of this work was to describe the performance of a new prototype truck container designed to improve the microenvironment and reduce the incidence of pale, soft and exudative (PSE) meat and dead on arrival (DOA) occurrences. Experiments were carried out for four different conditions: regular and prototype truck, both with and without wetting loaded cages at the farm (for bird thermal stress relief) just before transporting. While there was no difference in the DOA index (P ≥ 0.05), the prototype truck caused a reduction (P < 0.05) in the occurrence of PSE meat by 66.3% and 49.6% with and without wetting, respectively. The results of this experiment clearly revealed a low‐cost solution for transporting chickens that yields better animal welfare conditions and improves meat quality.
Oral antibiotics enhance antibody responses to keyhole limpet hemocyanin in orally but not muscularly immunized chickens
Authors: Murai Atsushi , Kitahara Kazuki , Okumura Shouta , Kobayashi Misato , Horio Fumihiko 
Published: August 2015

AbstractRecent studies have emphasized the crucial role of gut microbiota in triggering and modulating immune response. We aimed to determine whether the modification of gut microbiota by oral co‐administration of two antibiotics, ampicillin and neomycin, would lead to changes in the antibody response to antigens in chickens. Neonatal chickens were given or not given ampicillin and neomycin (0.25 and 0.5 g/L, respectively) in drinking water. At 2 weeks of age, the chicks were muscularly or orally immunized with antigenic keyhole limpet hemocyanin (KLH), and then serum anti‐KLH antibody levels were examined by ELISA. In orally immunized chicks, oral antibiotics treatment enhanced antibody responses (IgM, IgA, IgY) by 2–3‐fold compared with the antibiotics‐free control, while the antibiotics did not enhance antibody responses in the muscularly immunized chicks. Concomitant with their enhancement of antibody responses, the oral antibiotics also lowered the Lactobacillus species in feces. Low doses of antibiotics (10‐fold and 100‐fold lower than the initial trial), which failed to change the fecal Lactobacillus population, did not modify any antibody responses when chicks were orally immunized with KLH. In conclusion, oral antibiotics treatment enhanced the antibody response to orally exposed antigens in chickens. This enhancement of antibody response was associated with a modification of the fecal Lactobacillus content, suggesting a possible link between gut microbiota and antibody response in chickens.
Effects of summer heat stress on physiological variables, ovulation and progesterone secretion in Pelibuey ewes under natural outdoor conditions in an arid region
Authors: Macías‐Cruz Ulises , Gastélum Miguel A. , Álvarez Francisco D. , Correa Abelardo , Díaz Raúl , Meza‐Herrera César A. , Mellado Miguel , Avendaño‐Reyes Leonel 
Published: August 2015

AbstractTen non‐lactating multiparous Pelibuey breed ewes were housed in a corral to evaluate the effects of summer thermal stress on physiologic variables, estrous behavior, ovulation and corpus luteum functionality under natural conditions of an arid region. In summer and autumn, daily estrous detection with a ram fitted with an apron and blood sample collections were performed during two natural estrous cycles. An environment of heat stress was detected in summer and thermoneutral in autumn. Rectal temperature and respiratory frequency were greater (P < 0.01) in summer than in autumn during the morning and afternoon. Season did not affect (P > 0.05) live weight, body condition, length of estrous cycle or percentage of ewes in estrous and ovulating. Compared with autumn, serum progesterone concentrations in summer decreased (P < 0.05) between days 8 and 14 of the estrous cycle. It is concluded that under outdoor conditions of arid regions, while estrous and ovulatory activities of Pelibuey ewes were not affected by summer thermal stress, the corpus luteum functionality was decreased.
Effect of farm characteristics and practices on hygienic quality of ovine raw milk used for artisan cheese production in central Italy
Authors: Carloni Elisa , Petruzzelli Annalisa , Amagliani Giulia , Brandi Giorgio , Caverni Francesco , Mangili Piermario , Tonucci Franco 
Published: August 2015

AbstractA survey on ovine dairy farms directly transforming own‐produced milk, in the Italian Marche region, was carried out to assess flock and milking practices that may influence milk hygienic‐sanitary conditions. A census survey established that 24 dairy farms were located in this region. Bulk milk samples were collected throughout the milking period in each dairy farm in 2013. Analyzed variables were: (i) chemical parameters such as fat, protein and lactose content, dry matter and pH; and (ii) total bacterial (TBC) and somatic cell counts (SCC). Chemical parameter values were in agreement with published data while, geometric mean (GM) log10 SCC was 5.91 and TBC GM was 57 978 colony forming units/mL, in compliance with Eropean Union criteria. A positive correlation was found between SCC and TBC when GMs of all farm data were considered (Spearman's rho = 0.7925; P = 0.0001). Statistical analysis did not show significant correlation between SCC or TBC GM and dairy farm principal characteristics. Although SCC levels detected in the present study should suggest the need to implement mastitis control programs, Marche's dairy sheep flocks revealed a good hygienic condition level. This is an important aspect in implementing safety for end users of the final product.
Changes in diarrhea, nutrients apparent digestibility, digestive enzyme activities of weaned piglets in response to chitosan‐zinc chelate
Authors: Qian Lichun , Yue Xiaojing , Hu Luansha , Ma Yuanfei , Han Xinyan 
Published: August 2015

AbstractA total of 120 weanling barrows weighing 6.11 ± 0.20 kg were randomly allotted to four treatments with three replications (i.e. pen) of ten piglets per replicate. Pigs were received corn‐soybean basal diet (control) or the same basal diet supplemented with the following sources of zinc: (i) 100 mg/kg of Zn as ZnSO4; (ii) 100 mg/kg of Zn as chitosan‐Zn chelate (CS‐Zn); and (iii) 100 mg/kg of Zn as ZnSO4 mixed with chitosan (CS + ZnSO4). The results showed that CS‐Zn could highly improve average daily gain and average daily feed intake than those of ZnSO4 or CS+ ZnSO4 (P < 0.05). The pigs fed dietary CS‐Zn had lower diarrhea incidence and higher apparent digestibility of crude protein than those of the pigs fed dietary ZnSO4 (P < 0.05). The protease activities in duodenal content of the pigs receiving CS‐Zn diets was higher than that of the pigs fed dietary ZnSO4 or CS + ZnSO4 (P < 0.05). The amylase activity in duodenal content of the pigs fed dietary CS‐Zn was higher than that of the pigs receiving ZnSO4 diets or basal diets (P < 0.05). These results indicated that dietary CS‐Zn showed different bioactivities from ZnSO4 or CS + ZnSO4 in reducing the incidence of diarrhea, improving activities of digestive enzymes and growth performance of weaned pigs.
Development of a simple IgE‐independent anaphylactic model using buckwheat antigen and B‐type CpG oligodeoxynucleotide from Streptococcus thermophilus
Authors: Yamamoto Yoshinari , Shigemori Suguru , Nigar Shireen , Oshiro Kazushi , Wang Yeqin , Sato Takashi , Shimosato Takeshi 
Published: August 2015

AbstractWe developed a severe anaphylactic model in mice using buckwheat antigen and B‐type CpG‐oligodeoxynucleotides (CpG‐ODNs) from Streptococcus thermophilus genome. In typical systemic anaphylaxis models, animals are challenged with large quantity of antigens via an intravenous (i.v.) route. Here, we showed a simple anaphylactic shock after challenge via intraperitoneal (i.p.) route. The i.p. method is simpler than i.v. administration and has a lower risk for failure. To generate this anaphylactic model, 5‐week‐old female BALB/c mice were first i.p. sensitized with buckwheat antigen mixed with B‐type CpG‐ODN. After 2 weeks, mice were challenged with antigen to induce anaphylactic shock, which was evaluated by scoring the severity symptoms and measuring serum levels of various proteins and splenic cell producing cytokines. Immunoglobulin (Ig)G2a production and interferon‐γ positive cells were markedly increased in mice immunized with antigen mixed with B‐type CpG‐ODN, whereas serum IgE levels were decreased by B‐type CpG‐ODN. We also examined the effects of various ODNs (A, B and C‐type CpG‐ODNs) and antigens (buckwheat, α‐casein, β‐lactoglobulin and ovalbumin) on anaphylactic severity, and found that the combination of buckwheat and B‐type CpG‐ODN induced the most intense anaphylactic shock. This model is expected to contribute to the study of the prevention of anaphylactic shock.
Clinically important drug–drug interactions in poly‐treated elderly outpatients: a campaign to improve appropriateness in general practice
Authors: Raschi Emanuel , Piccinni Carlo , Signoretta Vincenzo , Lionello Lucio , Bonezzi Silvia , Delfino Marcello , Di Candia Lucia , Di Castri Lucio , Pieraccini Fabio , Carati Daniela , Poluzzi Elisabetta , De Ponti Fabrizio ,   on behalf of the Emilia‐Romagna elderly poly‐treated patients research group
Published: August 2015

AimsThe aim was to assess the impact of a campaign for general practitioners (GPs) to reduce clinically‐important drug–drug interactions (DDIs) in poly‐treated elderly patients.MethodsWe compiled a list of 53 DDIs and analyzed reimbursed prescriptions dispensed to poly‐treated (≥four drugs) elderly (>65 years) patients in the Emilia Romagna region during January 2011–June 2011 (first pre‐intervention period), January 2012–June 2012 (second pre‐intervention period) and January 2013–June 2013 (post‐intervention period). Educational initiatives to GPs were completed in July 2012–December 2012. Pre‐test/post‐test analysis (2013 vs. 2012) was performed, also using predicted 2013 data (P < 0.01 for statistical significance).ResultsDespite the slight increase in poly‐therapy rate (16% in 2013, +1.5% from 2011), we found a stable or slightly declining number of potential DDIs for each elderly poly‐treated patient (~1.5). In 2013, 11 DDIs exceeded 5% of prevalence rate: antidiabetics‐β‐adrenoceptor blockers ranked first (20.3%), followed by ACE Inhibitors (ACEIs)/sartans‐non steroidal anti‐inflammatory drugs (NSAIDs) (16.4%), diuretics‐NSAIDs (13.6%), selective serotonin re‐uptake inhibitors (SSRIs)‐NSAIDs/acetyl salicylic acid (ASA) (12.7%) and corticosteroids‐NSAIDs/ASA (9.7%). A remarkable reduction emerged for NSAID‐related DDIs (diuretics‐NSAIDs peaked −14.5%; P < 0.01), whereas prevalence of antidiabetics‐β‐adrenoceptor blockers increased (+7.9%; P < 0.01). When using predicted values, the statistical significance disappeared for antidiabetics‐β‐adrenoceptor blockers (+1.3%; P = 0.04), whereas it persisted for almost all NSAIDs‐related DDIs: ACEIs/sartans‐NSAIDs (−3.0%), diuretics‐NSAIDs (−6.0%), SSRIs‐NSAIDs/ASA (−5.9%).ConclusionsThis campaign contained the burden of DDIs in poly‐treated elderly patients by 1) reducing most prevalent DDIs, especially NSAIDs‐related DDIs and 2) balancing the observed rise in poly‐therapy rate with stable rate in overall prescriptions of potentially interacting drugs per patient.
Robot‐assisted partial nephrectomy in cystic tumours: analysis of the Vattikuti Global Quality Initiative in Robotic Urologic Surgery (GQI‐RUS) database
Authors: Novara Giacomo , La Falce Sabrina , Abaza Ronney , Adshead James , Ahlawat Rajesh , Buffi Nicolò Maria , Challacombe Ben , Dasgupta Prokar , Moon Daniel A. , Parekh Dipen J. , Porpiglia Francesco , Rawal Sudhir , Rogers Craig , Volpe Alessandro , Bhandari Mahendra , Mottrie Alexander 
Published: August 2015

ObjectiveTo evaluate the outcomes of robot‐assisted partial nephrectomy (RAPN) in cystic tumours, analysing a large, multi‐institutional, retrospective series of RAPN, as limited data are available about the outcome of RAPN in cystic tumours.Patients and MethodsWe evaluated 465 patients who received RAPN for either cystic or solid tumours from 2010 to 2013 and included in the multi‐institutional, retrospective Vattikuti Global Quality Initiative in Robotic Urologic Surgery (GQI‐RUS) database. Univariable and multivariable linear and logistic regression models addressed the association of cystic tumours with perioperative outcomes.ResultsIn all, 54 (12%) tumours were cystic. Cystic tumours were associated with significantly lower operative time (t −3.9; P < 0.001), once adjusted for the effect of covariates, whereas blood loss and warm ischaemia time were similar. Postoperative any grade complications were recorded in 66 solid (16%) and nine cystic (17%) tumours (P = 0.08). In multivariable analysis, cystic tumours were not associated with a significantly lower risk of any grade postoperative complications [odds ratio (OR) 0.9; P = 0.8]. Similarly, presence of tumours with cystic features was not associated with a significantly different risk of high‐grade postoperative complications (OR 2.2; P = 0.1). Prevalence of cancer histology and positive surgical margin rates were similar in cystic and solid tumours. Cystic tumours were not associated with significantly different postoperative estimated glomerular filtration rate (t 0.4; P = 0.7), once adjusted for the effect of covariates.ConclusionsRAPN can be performed in cystic renal tumours with perioperative, pathological, and functional outcomes similar to those achievable in solid tumours.
Suicide and accidental deaths among patients with non‐metastatic prostate cancer
Authors: Dalela Deepansh , Krishna Nandita , Okwara James , Preston Mark A. , Abdollah Firas , Choueiri Toni K. , Reznor Gally , Sammon Jesse D. , Schmid Marianne , Kibel Adam S. , Nguyen Paul L. , Menon Mani , Trinh Quoc‐Dien 
Published: August 2015

ObjectiveTo determine if American men with prostate cancer are at increased risk of suicide/accidental death compared with other cancers and if the receipt of definitive treatment alters this association, as patients with cancer are at increased risk of suicide and evidence suggests a relationship between suicides and deaths due to accidents and externally caused injuries.Patients and MethodsDemographic, socio‐economic and tumour characteristics of men with prostate cancer and men with other solid malignancies were extracted from the Surveillance, Epidemiology and End Results (SEER) database (1988–2010). Poisson regression models were fitted to compare the incidence of suicidal and accidental deaths in prostate cancer vs other solid cancers. Multivariate Cox regression was used to determine if receipt of definitive primary treatment impacted the risk of suicide or accidental death in men with localised/regional prostate cancer.ResultsRisk of suicidal and accidental death was significantly lower in men with prostate cancer (1 165 [0.2%] and 3 199 [0.6%]) than men with other cancers (2 232 [0.2%] and 4 501 [0.5%], respectively), except within the first year of diagnosis (adjusted relative risk [ARR] 3.98, 95% confidence interval [CI] 3.02–5.23 and ARR 4.22, 95% CI 3.24–5.51, respectively, 0–3 months after diagnosis). Men with non‐metastatic prostate cancer who were White, uninsured, or recommended but did not receive treatment (hazard ratio vs treated 1.44, 95% CI 1.20–1.72, and 1.44, 95% CI 1.30–1.59, both P < 0.001) were at increased risk of suicidal and accidental mortality, respectively. Absence of data about previous co‐morbidities and drug addictions in the SEER dataset was an important limitation.ConclusionsRelative to other cancers, men with prostate cancer were at increased risk of suicide and accidental deaths within the first year of diagnosis and when definitive treatment was recommended but not received, suggesting the need for close monitoring and coordination with mental health professionals in at‐risk men with potentially curable disease.