bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health literacy for anxiety disorders: how perceptions of symptom severity might relate to recognition of psychological distress
Authors: Paulus Daniel J. , Wadsworth Lauren Page , Hayes-Skelton Sarah A. 
Published: June 2015

Purpose– Improving mental health literacy is an important consideration when promoting expedient and effective treatment seeking for psychological disorders. Low recognition serves as a barrier to treatment and the purpose of this paper is to examine recognition by lay individuals of severity for three psychological disorders: social anxiety, generalized anxiety, and major depression using a dimensional approach.Design/methodology/approach– Vignettes of mild/subclinical, moderate, and severe cases of each disorder were rated for severity by a team of expert assessors and 270 participants (mean age=26.8; 76.7 percent women).Findings– Difference ratings were calculated comparing participants’ responses to scores from the assessors. A within-groups factorial ANOVA with LSD follow-up was performed to examine the effects ofDiagnosisandSeverityon difference ratings. Both main effects (Diagnosis,F(2, 536)=35.26,Mse=1.24;Severity,F(2, 536)=9.44,Mse=1.93) and the interaction were significant (F(4, 1,072)=13.70,Mse=1.13) allp’s < 0.001. Social anxiety cases were under-rated in the mild/subclinical and moderate cases, generalized anxiety cases were under-rated at all three severities, and major depression cases were over-rated at all three severities.Social implications– Judgments of severity may underlie the low recognition rates for social anxiety disorder and generalized anxiety disorder. Future efforts should focus on improved recognition and education regarding anxiety disorders in the population, particularly before they become severe.Originality/value– This project demonstrates the importance of considering judgments of symptom severity on a continuum, and in a range of cases, rather than just the ability to correctly label symptoms, when determining whether or not people recognize psychological disorders.
Uses and risks of microblogging in organisational and educational settings
Authors: Ahmad Kharman Shah Nordiana , Latif Shabgahi Soureh , Cox Andrew M. 
Published: June 2015

AbstractPurposeThe paper aims to clarify the relationship between organisational and educational use of microblogging. Although enterprise and education are very different sectors of activity and have diverse research traditions, this review argues that there is a benefit to be derived from comparing research work across the two settings.Design/methodology/approachThe paper conducted a thematic analysis of research literature on microblogging for the two fields. The collection comprised around 30 papers on enterprise microblogging (EMB), defined as use of microblogging primarily with internal organisational audiences behind the firewall. Twenty‐five research papers on microblogging in higher education (MIHE) made up the rest of the corpus. A generic framework of uses and risks of microblogging was produced and it is the main contribution of the paper.FindingsThe comparison of the literature on microblogging in the two sectors has led to the development and evaluation of a generic framework, which graphically presents its use and risks. The paper has introduced some ideas about how microblogging is used and they are potentially useful for the other context, for instance, the concept of awareness from the organisational literature. While the organisational literature has a major focus on risk, this appreciation is far less developed in the educational context; increasing such an emphasis would improve employability.Research limitations/implicationsMost of the research on EMB to date has been about uses of microblogging in large organisations, often information technology based. Research on MIHE has been experiments on the effect of microblogging in learning and classroom activities. Therefore, there is room to expand research beyond these settings.Practical implicationsThe developed framework can be a useful guide for other researchers to explore issues around microblogging in different settings, such as educators using microblogging for research or use in other contexts. It is helpful to researchers to see how different theoretical concepts and research methods might be deployed in another context. The framework might also be used for comparing other technologies apart from Web 2.0/microblogging.Originality/valueThe paper has been the first review that we are aware of that has concentrated on the uses and risks of microblogging technologies in these particular contexts, organisation and education.
CAD/CAM‐fabricated implant‐supported restorations: a systematic review
Authors: Patzelt Sebastian Berthold Maximilian , Spies Benedikt C. , Kohal Ralf J. 
Published: June 2015

AbstractObjectivesThe aim of this systematic review was to identify and summarize the available literature related to CAD/CAM‐fabricated implant‐supported restorations.Materials and methodsA systematic review of the literature was conducted using the Cochrane Library and the US Library of Medicine, National Institute of Health databases (Pubmed). Several search runs with specific search terms were performed and combined. All published papers available on the databases up to January 15, 2015 were considered with primarily no restrictions.ResultsAbout 12 of 3484 identified papers met the inclusion criteria and were analyzed in the present review. One paper reported results on implant‐supported single crowns (SCs), one on partial fixed dental prostheses (FDPs), and 10 papers reported results on full‐arch screw‐retained FDPs. Publications on SCs and FDPs were very limited but it was possible to identify 10 papers reporting adequate results on full‐arch screw‐retained FDPs. Survival rates ranged between 92% and 100% with observation times of 1–10 years.ConclusionThe available data provided promising results for CAD/CAM‐fabricated implant‐supported restorations; nonetheless, current evidence is limited due to the quality of available studies and the paucity of data on long‐term clinical outcomes of 5 years or more. In the sense of an evidence‐based dentistry, the authors recommend further studies designed as randomized controlled clinical trials and reported according to the CONSORT statement.
Simulating tropical forage growth and biomass accumulation: an overview of model development and application
Authors: Andrade A. S. , Santos P. M. , Pezzopane J. R. M. , de Araujo L. C. , Pedreira B. C. , Pedreira C. G. S. , Marin F. R. , Lara M. A. S. 
Published: June 2015

AbstractCrop models can aid the synthesis and application of knowledge, planning of experiments and forecasting in agricultural systems. Few studies have reviewed the uses and applications of these models for tropical forages. The purpose of this study was to review the information available in this scientific area, highlighting the main models, their applications and limitations. Several empirical models have been developed to predict the growth and biomass accumulation of tropical forages, especially for the genera Cynodon, Paspalum, Panicum and Brachiaria. Their application, however, is often location or region specific. The adaptation of mechanistic models to accurately predict biomass accumulation in tropical grasses is still limited. Recent advances have been made on the plot‐scale and farm‐scale process‐based models ALMANAC, CROPGRO Perennial Forage and agricultural production systems simulator (APSIM), with promising results. In addition, global‐scale process‐based models, such as the Century Agroecosystem Model and the Orchidee Grassland Management Model, have been tested for tropical grassland areas. A greater number of region‐specific calibrations of empirical models can enhance their use, and improved databases and model parameterizations for a wide range of tropical grasses will enable the continuous improvement of mechanistic models.
Reconsideration of BCR‐ABL protein flow cytometric immunobead assay: how potent to diagnose and monitor chronic myeloid leukemia?
Authors: Kelani R. , Monem F. 
Published: June 2015

SummaryIntroductionChronic myeloid leukemia (CML) is typically associated with the Philadelphia chromosome, resulting in the production of BCR‐ABL fusion oncoprotein with upregulated tyrosine kinase activity. We aimed to evaluate a new flow cytometric immunobead assay to detect BCR‐ABL protein in a group of patients with CML.MethodsWe enrolled 49 patients with CML, whose qRT‐PCR and/or cytogenetic analysis of Philadelphia chromosome aberration was available, including tyrosine kinase inhibitors (TKIs)‐naïve and (TKIs)‐treated patients with various levels of response. Twenty Philadelphia‐negative healthy individuals were also enrolled to obtain analytical negative controls. Peripheral blood samples were analyzed for BCR‐ABL fusion protein by flow cytometry.ResultsThe BCR‐ABL fusion protein flow cytometric assay seemed efficacious to both diagnose the presence (P‐value <0.0001) and distinguish the levels (P‐value = 0) of the Philadelphia chromosome aberration. Groups of TKI‐naïve and TKI‐treated patients as well as levels of molecular/cytogenetic response to TKI‐therapy were effectively discriminated (P‐value <0.01). The receiver operating characteristic (ROC) curve analysis indicated the diagnostic value of the assay as excellent (AUC = 0.95, P‐value = 0).ConclusionsThe evaluated BCR‐ABL fusion protein assay might be useful for diagnosing and monitoring Philadelphia chromosome aberration.
Impact of short‐term exposure of antifungal agents on hemolysin activity of oral Candida dubliniensis isolates from Kuwait and Sri Lanka
Authors: Ellepola Arjuna N. B. , Jayathilake J. A. M. Sumedha , Sharma Prem N. , Khan Zia U. 
Published: June 2015

AbstractObjectiveAbility to produce hemolysin by Candida species is an important determinant of its pathogenicity. Candida dubliniensis is implicated in the causation of oral candidosis, which can be treated with polyene, echinocandin, and azole groups of antifungal agents as well as chlorhexidine. After oral application, however, the concentrations of these agents tend to decrease quickly to subtherapeutic levels due to the peculiarity of the oral environment. In this study, we have evaluated the effect of short‐term exposure of sublethal concentrations of these drugs on hemolysin production by oral C. dubliniensis isolates obtained from two different geographical locale.Materials and methodsTwenty C. dubliniensis oral isolates obtained from Kuwait and Sri Lanka were exposed to sublethal concentrations of nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole, and chlorhexidine for 1 h. Thereafter, the drugs were removed by dilution and the hemolysin production determined by a previously described plate assay.ResultsHemolysin production of these isolates was significantly suppressed with a percentage reduction of 17.09, 16.45, 17.09, 11.39, 8.23 and 12.03 following exposure to nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole, and chlorhexidine, respectively.ConclusionBrief exposure to sublethal concentrations of drugs with antifungal properties appears to reduce the pathogenic potential of C. dubliniensis isolates by suppressing hemolysin production.
Drug‐drug interactions in pharmacologic management of gastroparesis
Authors: Youssef A. S. , Parkman H. P. , Nagar S. 
Published: June 2015

AbstractBackgroundGastroparesis is a disorder characterized by delayed gastric emptying due to chronic abnormal gastric motility. The treatment of the disease often entails the co‐administration of several classes of pharmacological agents. These agents may be metabolized via the same pathway. Inhibition or induction of a shared metabolic pathway leads to change in the systemic levels of prescribed drugs, possibly leading to undesired clinical outcomes.PurposeThis review discusses different pharmacological treatment for gastroparesis patients and describes the potential for drug‐drug interactions (DDIs) in some of the combinations that are currently used. Prokinetic agents such as metoclopramide and domperidone are the cornerstone in treatment of gastroparesis. Antiemetic agents such as promethazine and ondansetron are frequently administered to gastroparesis patients to reduce nausea and vomiting. Gastroparesis is prevalent in diabetic patients and therefore antidiabetic agents are also prescribed. Many of these co‐administered drugs are metabolized via common drug metabolizing enzymes and this can trigger potential DDIs. The scientific literature was reviewed from the years 1975–2014 for original research articles and reviews that evaluated DDIs in gastroparesis. Many commonly prescribed combinations were predicted to cause potential DDIs in gastroparesis patients. This review will help inform about potential hazardous combinations. This information will hopefully lead to less adverse effects and more successful gastroparesis management.
The N‐glycan on Asn54 affects the atypical N‐glycan composition of plant‐produced interleukin‐22, but does not influence its activity
Authors: Wilbers Ruud H. P. , Westerhof Lotte B. , Reuter Lauri J. , Castilho Alexandra , van Raaij Debbie R. , Nguyen Dieu‐Linh , Lozano‐Torres Jose L. , Smant Geert , Hokke Cornelis H. , Bakker Jaap , Schots Arjen 
Published: June 2015

SummaryHuman interleukin‐22 (IL‐22) is a member of the IL‐10 cytokine family that has recently been shown to have major therapeutic potential. IL‐22 is an unusual cytokine as it does not act directly on immune cells. Instead, IL‐22 controls the differentiation, proliferation and antimicrobial protein expression of epithelial cells, thereby maintaining epithelial barrier function. In this study, we transiently expressed human IL‐22 in Nicotiana benthamiana plants and investigated the role of N‐glycosylation on protein folding and biological activity. Expression levels of IL‐22 were up to 5.4 μg/mg TSP, and N‐glycan analysis revealed the presence of the atypical Lewis A structure. Surprisingly, upon engineering of human‐like N‐glycans on IL‐22 by co‐expressing mouse FUT8 in ΔXT/FT plants a strong reduction in Lewis A was observed. Also, core α1,6‐fucoylation did not improve the biological activity of IL‐22. The combination of site‐directed mutagenesis of Asn54 and in vivo deglycosylation with PNGase F also revealed that N‐glycosylation at this position is not required for proper protein folding. However, we do show that the presence of a N‐glycan on Asn54 contributes to the atypical N‐glycan composition of plant‐produced IL‐22 and influences the N‐glycan composition of N‐glycans on other positions. Altogether, our data demonstrate that plants offer an excellent tool to investigate the role of N‐glycosylation on folding and activity of recombinant glycoproteins, such as IL‐22.
Dermatitis Artefacta in Childhood: A Retrospective Analysis of 44 Patients, 1976–2006
Authors: Alcántara Luna Sara , García Bravo Begoña , Rodríguez Pichardo Antonio , Camacho Martínez Francisco M. 
Published: June 2015

AbstractBackgroundDermatitis artefacta (DA) consists of self‐inflicted skin lesions that the patient denies having produced.ObjectivesTo conduct a single‐center retrospective clinical review of children and adolescents diagnosed with DA.MethodsFrom 1976 to 2006, data were collected on children diagnosed with DA who were seen in the Department of Dermatology in our hospital. Clinical and epidemiologic features are described. Forty‐four children (mean age 12.9 yrs) were selected, representing 21.9% of the total patients with DA recorded (n = 201) during this period.ResultsThe most frequent clinical forms were excoriations (16 [36.4%]) and ulcers (10 [22.7%]), followed by blisters (7 [15.9%]), burns (3 [6.8%]), contact dermatitis (3 [6.8%]), hematomas (2 [4.5%]), panniculitis (1 [2.3%]), cheilitis (1 [2.3%]), and hyperpigmentation (1 [2.3%]). Sixteen were located exclusively on the face and neck, whereas 28 also had other locations (upper limbs, n = 10; lower limbs, n = 9; thorax, n = 5; abdomen, n = 4). Cutaneous lesions were treated with occlusive bandages using zinc paste or a plaster splint when necessary.ConclusionTo our knowledge, this is the largest reported series of DA in childhood. This complicated psychodermatologic condition requires correct diagnosis, appropriate management, and psychiatric assessment.
Pediatric hematopoietic stem cell transplantation in China: Data and trends during 1998–2012
Authors: Du Hong , Chen Jing , Qin Maoquan , Fang Jianpei , Li Zhiguang , Zhu Yiping , Sun Xin , Huang Dongsheng , Yu Jie , Tang Yongmin , Hu Shaoyan , Li Junhui , Zhang Zhiquan , Luan Zuo 
Published: June 2015

AbstractThe success of treating a wide variety of pediatric diseases with HSCT, hematologic malignancies in particular, has resulted in an increased number of long‐term survivors. This study is the first large‐scale, multicentre report that describes the evolution of pediatric HSCTs in China during the period of 1998–2012. Of all 1052 patients, 266 cases were treated with autologous HSCs and 786 used allogeneic HSCs. The disease indications for HSCTs mainly included leukemias, lymphoma, solid tumors, and non‐malignant disorders. The total number of HSCTs, especially unrelated donor transplants, appeared to be increasing year by year. For patients with neuroblastoma, the therapeutic efficacy seemed to be poor, with a five‐yr OS and DFS rate of 34.5 ± 14.3% and 20.7 ± 9.6%, respectively. In contrast, the survival of patients with SAA was prominently improved, and their five‐yr OS and DFS rates were 82.8 ± 4% and 80.7 ± 4.1%, respectively. Patients who received cord blood transplants had a lower incidence of acute GVHD than that of PB and/or BM transplants from unrelated donors. This report offers us a valuable resource for evaluating the changes in HSCTs in China over the past 14 yr.
Probing the functional role of tick metalloproteases
Authors: Ali Abid , Khan Sardar , Ali Ijaz , Karim Shahid , da Silva Vaz Itabajara , Termignoni Carlos 
Published: June 2015

AbstractTick saliva assists feeding through a complex mixture of compounds that disarm the host homeostasis processes, such as platelet aggregation, vasoconstriction and blood clotting, as well as innate and acquired immune responses. Although the various properties of tick salivary glands have sparked great interest as candidate sources for anti‐tick vaccines to prevent tick and tick‐borne diseases, antigens that can be useful to induce an immune response against tick bites or the pathogens transmitted by ticks have not yet been developed. Metalloproteases, which have been found in tick saliva, salivary gland, ovary and midgut, play an important role in inflammation, immunomodulation, fibrinolysis, blood protein digestion, nociception, vitellogenesis, remodelling of extracellular matrix and pathogen transmission. A large proportion of tick metalloproteases belong to the metzincin group, whose members characteristically have a highly conserved zinc‐binding motif integrated into the central α helix at the active site, and a methionine‐containing triad called Met‐turn followed by a cysteine‐rich domain at the C‐terminal site. This review discusses specifically the biological aspects of metalloproteases in tick physiology that have been published to date.
The Love Affair between Philosophy and Poetry: Aristotle's Poetics and Narrative Identity
Authors: Carli Silvia 
Published: June 2015

ABSTRACTIn order to grasp the distinctive character of the object imitated in tragedies, Aristotle's Poetics introduces a new notion of action (praxis), which does not refer to individual ethical deeds as in the Ethics. Rather, it signifies a whole with a beginning, a middle, and an end, whose constitutive components are events (pragmata). This paper argues that the notion of agents undergoes a parallel transformation in the treatise on poetry. It no longer refers exclusively to the authors of ethical deeds, but to the characters who enact the entire dramatic action (prattontes). Their nature can be understood in terms of a potential story whose logos (account, articulation) is a muthos (story, narrative). On this ground, the suggestion is made that the Poetics provides the elements of a narrative conception of human identity.
Entry Threats and Inefficiency in ‘Efficient Bargaining’
Authors: Pal Rupayan , Saha Bibhas 
Published: June 2015

AbstractWe study limit pricing in a model of entry with asymmetric information, where the incumbent firm's wage is endogenously determined through ‘efficient bargaining’ with its union. In the presence of entry threat, the incumbent firm‐union pair may face a conflict between rent sharing and transmitting its cost information. When the wage is not observable to outsiders and employment is the only signalling instrument, over‐employment features in all entry deterring contracts. When the wage is also observable, information transmission becomes easier. Most of the time, then, but not always, the efficient contract deters (induces) entry against the low (high) cost incumbent.
Money, Empowerment and Neglect – The Europeanization of Gender Equality Promotion in Greek and Portuguese Employment Policies
Authors: Zartaloudis Sotirios 
Published: June 2015

AbstractThis article examines the impact of the European Employment Strategy (EES) on Greek and Portuguese employment policies (GEP and PEP, respectively) with regard to gender equality promotion during 1995–2009. It focuses on the three main EES goals of gender mainstreaming, reconciliation of work and family, and reducing gender pay gaps, drawing on 44 semi‐structured interviews, official documents and the academic literature. The first part discusses the content of GEP and PEP before the introduction of the EES, arguing that gender equality promotion was absent in both countries. The second part examines the reforms promoting gender equality in GEP and PEP after the introduction of the EES in 1997, arguing that both countries implemented a substantial policy change which can be observed in two areas: first, expanding training and providing start‐up subsidies for women; and, second, expanding care facilities to promote the reconciliation of work and family life. In the third part it is argued that these reforms were linked to the EES and that the Europeanization of GEP occurred through the European Social Fund's conditionality, whereas in the case of PEP, Europeanization occurred through the external empowerment of domestic policy entrepreneurs who used the EES to promote their pro‐gender equality agenda. Overall, in both countries the EU caused a considerable but not transformative change in their welfare states, with the EES constituting the key driver of pro‐gender equality reforms in employment policy.
The assessment of inflammatory activity and toxicity of treated sewage using RAW264.7 cells
Authors: Makene Vedastus W. , Pool Edmund J. 
Published: June 2015

AbstractToxicity and inflammatory activity of wastewater samples were evaluated using RAW264.7 cells as a bioassay model. The RAW264.7 cell cultures were exposed to sterile filtered wastewater samples collected from a sewage treatment plant. Cell viability was evaluated using WST‐1 and XTT assays. Inflammatory effects of samples were assessed by determination of nitric oxide (NO) and interleukin 6 (IL‐6). The NO was estimated using the Griess reaction and IL‐6 was measured by enzyme‐linked immunoassay. All samples had no toxicity effects to RAW264.7 cells, however they significantly (P < 0.001) induced NO and IL‐6 production. The highest NO (12.5 ± 0.38 μM) and IL‐6 (25383.84 ± 2327 pg/mL) production was induced by postbiofiltration sample. Final effluent induced the lowest inflammatory response, which indicates effective sewage treatment. In conclusion, wastewater samples can induce inflammatory activities in RAW264.7 cells. The RAW264.7 cells, therefore, can be used as a model for monitoring the quality of treated sewage.