bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic‐assisted pancreaticoduodenectomy in a child with gastrinoma
Authors: Murase Naruhiko , Uchida Hiroo , Tainaka Takahisa , Kawashima Hiroshi , Tanaka Yujiro , Amano Hizuru , Kishimoto Hiroshi 
Published: September 2015

AbstractGastrinoma is rare in children. We report the case of a 9‐year‐old boy with weight loss and vomiting. Upper gastrointestinal imaging showed severe stenosis of the duodenum. Although gastrin was very high, imaging did not show a gastrinoma. Selective arterial secretagogue injection (SASI) test indicated a tumor within the gastroduodenal arterial zone. In accordance with the SASI test result, we performed laparoscopic‐assisted pancreaticoduodenectomy (LAPD). Postoperative biochemistry confirmed complete resection of the gastrinoma, and the patient was asymptomatic at follow up, 30 months after surgery. Even in patients with negative imaging for gastrinoma, aggressive resection following accurate localization on SASI test is biochemically curative. In such cases, the tumor is probably very small and LAPD may offer a minimally invasive procedure. As far as we know, LAPD in a child has not been previously reported.
Secondary neuroendocrine tumor after allogeneic bone marrow transplantation
Authors: Tamura Shinichi , Ishida Hiroyuki , Naito Takeshi , Kondo Osamu , Inoue Masami , Kawa Keisei , Kawabata Kenji , Hojo Hiroshi , Ouchi Kazutaka , Imamura Toshihiko 
Published: September 2015

AbstractHere we report a case of aggressive neuroendocrine tumor (NET), which is an extremely rare secondary solid tumor that occurs after allogeneic hematopoietic cell transplantation (allo‐HSCT). A patient with chronic active Epstein–Barr virus infection received allo‐HSCT from an HLA‐DR two allele‐mismatched unrelated donor. Four years later, he developed NET with multiple metastases. He received thoraco‐abdominal irradiation as a conditioning regimen, and developed repeated episodes of intestinal graft‐versus‐host disease, for which he received long‐term immunosuppressive therapy. Although these factors may be potential contributing factors to the development of secondary NET, the exact pathogenesis remains unclear.
The Short‐Term Economic Impact of Levying E‐Tolls on Industries
Authors: Stofberg Francois Jacobus , Van Heerden Jan 
Published: September 2015

AbstractTERM is used to analyse the short‐term regional economic impact of an increase in industries' transport costs when paying E‐Tolls. Market‐clearing and accounting equations allow regional economies to be represented as an integrated framework, labour adjusts to accommodate increasing transportation costs, and investments change to accommodate capital that is fixed. We concluded that costs from levying E‐Tolls on industries are small in comparison to total transport costs, and the impact on economic aggregates and most industries are marginal: investments (−0.404%), gross domestic product (GDP) (−0.01) and consumer price inflation (−0.10%). This is true even when considering costs and benefits on industries as well as consumers. Industries that experienced the greatest decline in output were transport, construction and gold. Provinces that are closer to Gauteng and have a greater share of severely impacted industries experienced larger GDP and real income reductions. Mpumalanga's decrease in GDP was 17% greater than Gauteng's.
Effects of riboflavin and amotosalen photoactivation systems for pathogen inactivation of fresh‐frozen plasma on fibrin clot structure
Authors: Hubbard Thomas , Backholer Lucy , Wiltshire Michael , Cardigan Rebecca , Ariëns Robert A.S. 
Published: September 2015

BACKGROUNDFresh‐frozen plasma (FFP) transfusion carries a risk of viral transmission from donor to recipient. Riboflavin (Mirasol) and amotosalen (Intercept) are two pathogen inactivation (PI) methods that may enhance the safety of FFP for transfusion. Our study investigated the effects of Mirasol and Intercept treatment on fibrin formation and clot structure.STUDY DESIGN AND METHODSFFP underwent either Mirasol or Intercept treatment, and aliquots were taken before addition of the compound, before illumination (after addition of compound only), and after treatment (addition of compound plus illumination). All samples underwent turbidimetric analysis, lysis analysis, assessment of clot permeation, and analysis by laser scanning confocal microscopy.RESULTSAfter treatment, there was a decrease in optical density of the fibrin network for Mirasol and Intercept, lag time to fibrin formation was prolonged for Mirasol and lysis time for Intercept, clot permeability was significantly decreased, and clot density was increased for both.CONCLUSIONSOur study shows that plasma treated with Mirasol and Intercept produces denser clots consisting of thinner fibers and warrants further studies to evaluate the clinical significance of these structural changes in fibrin clot formation.
Labour Market Institutions and Household Consumption Insurance within OECD Countries
Authors: Lo Prete Anna 
Published: September 2015

AbstractThis paper tests empirically whether the effect of idiosyncratic income shocks on aggregate consumption depends on institutional features of national labour markets. The results show that, in a sample of 15 OECD countries, institutional heterogeneity is a significant determinant of the response of household consumption to country‐specific income shocks. This is consistent with the idea that institutionally provided social insurance may help increase income stability when people differ in their ability to access financial markets and smooth consumption fluctuations.
Corneal and anterior segment foreign body trauma in dogs: a review of 218 cases
Authors: Tetas Pont Roser , Matas Riera Marian , Newton Richard , Donaldson David 
Published: September 2015

AbstractObjectivesTo review clinical data on dogs that suffered a corneal and anterior segment foreign body (CASFB) trauma and to determine the risk factors for foreign body (FB) trauma and subsequent enucleation.Animals studiedDogs with CASFB presented to the Animal Health Trust (AHT) from January 2000 to December 2012.ProceduresClinical data for CASFB cases were compared to those available for the remaining AHT ophthalmic population over the same period. The depth of the FB trauma was divided into five categories. The type of FB and method of removal were described for each category. The degree of secondary uveitis and lens involvement was graded and correlated with subsequent enucleation.ResultsThe mean age (standard deviation) of 218 identified CASFB cases was 3.96 (2.95) years. Risk factors for CASFB trauma were dogs younger than 5 years, English Springer Spaniels, Labrador Retrievers, and working dogs. Most dogs required general anesthesia for FB removal, and hypodermic needles were the most commonly used instrument. The lens was involved in some cases with a full‐thickness CASFB trauma (n = 49, 45%), but most suffered a minor lens trauma (n = 37, 76%). The lens trauma and phacoclastic uveitis were managed medically in most dogs (n = 37, 76%), and phacoemulsification was only elected as initial treatment in some dogs (n = 10, 20%). Enucleation was required overall in 6% of dogs. Statistically significant associations were found between enucleation and depth of FB trauma, degree of uveitis, and severity of lens trauma (P < 0.001).ConclusionsYoung dogs, English Springer Spaniels, Labrador Retrievers, and working dogs had an increased risk of CASFB trauma. Risk factors for enucleation were full‐thickness FB penetration, severe lens trauma, and severe uveitis.
Quantifying Wheelchair Basketball Match Load: A Comparison of Heart-Rate and Perceived-Exertion Methods
Authors: Iturricastillo Aitor , Yanci Javier , Granados Cristina , Goosey-Tolfrey Victoria 
Published: September 2015

Purpose:To describe the objective and subjective match load (ML) of wheelchair basketball (WB) and determine the relationship between session heart-rate (HR) -based ML and rating-of-perceived-exertion (RPE) -based ML methods.Methods:HR-based measurements of ML included Edwards ML and Stagno training impulses (TRIMPMOD), while RPE-based ML measurements included respiratory (sRPEres) and muscular (sRPEmus). Data were collected from 10 WB players during a whole competitive season.Results:Edwards ML and TRIMPMOD averaged across 16 matches were 255.3 ± 66.3 and 167.9 ± 67.1 AU, respectively. In contrast, sRPEres ML and sRPEmus ML were found to be higher (521.9 ± 188.7 and 536.9 ± 185.8 AU, respectively). Moderate correlations (r = .629–.648, P < .001) between Edwards ML and RPE-based ML methods were found. Moreover, similar significant correlations were also shown between the TRIMPMOD and RPE-based ML methods (r = .627–.668, P < .001). That said, only ≥40% of variance in HR-based ML was explained by RPE-based ML, which could be explained by the heterogeneity of physical-impairment type.Conclusion:RPE-based ML methods could be used as an indicator of global internal ML in highly trained WB players.
Quantification of Training and Competition Load Across a Season in an Elite Australian Football Club
Authors: Ritchie Dean , Hopkins Will G. , Buchheit Martin , Cordy Justin , Bartlett Jonathan D. 
Published: September 2015

Purpose:Load monitoring in Australian football (AF) has been widely adopted, yet team-sport periodization strategies are relatively unknown. The authors aimed to quantify training and competition load across a season in an elite AF team, using rating of perceived exertion (RPE) and GPS tracking.Methods:Weekly totals for RPE and GPS loads (including accelerometer data; PlayerLoad) were obtained for 44 players across a full season for each training modality and for competition. General linear mixed models compared mean weekly load between 3 preseason and 4 in-season blocks. Effects were assessed with inferences about magnitudes standardized with between-players SD.Results:Total RPE load was most likely greater during preseason, where the majority of load was obtained via skills and conditioning. There was a large reduction in RPE load in the last preseason block. During in-season, half the total load came from games and the remaining half from training, predominantly skills and upper-body weights. Total distance, high-intensity running, and PlayerLoad showed large to very large reductions from preseason to in-season, whereas changes in mean speed were trivial across all blocks. All these effects were clear at the 99% level.Conclusions:These data provide useful information about targeted periods of loading and unloading across different stages of a season. The study also provides a framework for further investigation of training periodization in AF teams.
The Relationship Between Match-Play Characteristics of Elite Rugby League and Indirect Markers of Muscle Damage
Authors: Oxendale Chelsea L. , Twist Craig , Daniels Matthew , Highton Jamie 
Published: September 2015

Purpose:While exercise-induced muscle damage (EIMD) after rugby league match play has been well documented, the specific match actions that contribute to EIMD are unclear. Accordingly, the purpose of this study was to investigate the positional demands of elite rugby league matches and examine their relationship with subsequent EIMD.Methods:Twenty-eight performances (from 17 participants) were captured using 10-Hz global positioning systems over 4 competitive matches. Upper- and lower-body neuromuscular fatigue, creatine kinase (CK), and perceived muscle soreness were assessed 24 h before and at 12, 36, and 60 h after matches.Results:High-intensity running was moderately higher in backs (6.6 ± 2.6 m/min) than in forwards (5.1 ± 1.6 m/min), whereas total collisions were moderately lower (31.1 ± 13.1 vs 54.1 ± 37.0). Duration (r = .90, CI: .77–.96) and total (r = .86, CI: .70–.95) and high-intensity distance covered (r = .76, CI: .51–.91) were associated (P < .05) with increased CK concentration postmatch. Total collisions and repeated high-intensity efforts were associated (P < .05) with large decrements in upper-body neuromuscular performance (r = –.48, CI: –.74 to .02; r = –.49, CI: –.77 to .05, respectively), muscle soreness (r = –.68, CI: –.87 to –.10, r = –.66, CI: –.89 to .21, respectively), and CK concentration (r = .67, CI: .42–.85; r = .73, CI: .51–.87, respectively). All EIMD markers returned to baseline within 60 h.Conclusion:Match duration, high-intensity running, and collisions were associated with variations in EIMD markers, suggesting that recovery is dependent on individual match demands.
First Complete Genome Sequence of Pseudomonas aeruginosa (Schroeter 1872) Migula 1900 (DSM 50071
T
), Determined Using PacBio Single-Molecule Real-Time Technology
Authors: Nakano Kazuma , Terabayashi Yasunobu , Shiroma Akino , Shimoji Makiko , Tamotsu Hinako , Ashimine Noriko , Ohki Shun , Shinzato Misuzu , Teruya Kuniko , Satou Kazuhito , Hirano Takashi 
Published: September 2015

ABSTRACT

The first complete genome sequence of the type strain
Pseudomonas aeruginosa
(Schroeter 1872) Migula 1900 (DSM 50071
T
) was determined in a single contig by PacBio RS II. The genome (6,317,050 bp, G+C content of 66.52%) contained 10 sets of >1,000-bp identical sequence pairs and 183 tandem repeats.
Draft Genome Sequence of a
Bacillus
Bacterium from the Atacama Desert Wetlands Metagenome
Authors: Vilo Claudia , Galetovic Alexandra , Araya Jorge E. , Gómez-Silva Benito , Dong Qunfeng 
Published: September 2015

ABSTRACT

We report here the draft genome sequence of a
Bacillus
bacterium isolated from the microflora of
Nostoc
colonies grown at the Andean wetlands in northern Chile. We consider this genome sequence to be a molecular tool for exploring microbial relationships and adaptation strategies to the prevailing extreme conditions at the Atacama Desert.
Complete Genome Sequences of Lineage IV Peste des Petits Ruminants Viruses from the Indian Subcontinent
Authors: Masdooq Aliyu Abdullahi , Pawar Rahul Mohanchandra , Parthiban Aravindh Babu R. , Ragavendhar K. , Sundarapandian G. , Thangavelu A. , Dhinakar Raj G. 
Published: September 2015

ABSTRACT
The complete genome sequences of two virulent lineage IV peste des petits ruminants viruses (PPRVs) isolated from clinically infected goats in the Indian subcontinent are reported here. This is the first report of a complete genome sequence of a virulent PPRV isolate from India in recent decades.
Draft Genome Sequence of Three Antibiotic-Resistant Leuconostoc mesenteroides Strains of Dairy Origin
Authors: Campedelli Ilenia , Flórez Ana Belén , Salvetti Elisa , Delgado Susana , Orrù Luigi , Cattivelli Luigi , Alegría Ángel , Felis Giovanna E. , Torriani Sandra , Mayo Baltasar 
Published: September 2015

ABSTRACT

Leuconostoc mesenteroides
is a lactic acid bacterium (LAB) commonly associated with fermented foods. Here, we report the genome sequence of three selected dairy strains, showing atypical antibiotic resistances (AR). Genome analysis provided a better understanding of the genetic bases of AR in
Leuconostoc
and its potential transferability among foodborne bacteria.
Improving the efficacy of elderly patients' hospital discharge through multi-professional safety briefings and behavioural change
Authors: Corrado Joanna , Topley Kathryn , Cracknell Alison 
Published: September 2015

AbstractAt Leeds Teaching Hospitals NHS Trust doctors type an electronic discharge advice note (eDAN) which includes a prescription for discharge medication, before a patient can be discharged from hospital. In 2014 staff on the Medical Admissions Unit for Older People identified significant delays in the completion of this document, with an average completion time of 138 minutes. This caused patient harm and exacerbated bed management problems as patients remained in hospital longer than necessary to obtain their discharge medication. Ward staff wanted to improve the efficacy of older peoples’ discharge by speeding up this process in as safe a manner as possible. A number of interventions were tested, led by junior doctors in a ‘bottom-up’ leadership strategy. Interventions included a daily discharge briefing to recap discharges and help junior doctors prioritise workload. After several months of sustained effort, the average time to complete eDANs fell by over an hour resulting in discharge medication dispensed earlier in the day and improved patient safety.
Respiratory and allergic health effects in a young population in proximity of a major industrial park in Oman
Authors: Alwahaibi Adil , Zeka Ariana 
Published: September 2015

BackgroundSohar industrial zone (SIZ), Oman, which started operating in 2006, contains many industries that potentially affect the health of the local population. This study's aim was to evaluate the health effects in a young population living near SIZ.MethodsPatient visits to state health clinics for acute respiratory diseases (ARD), asthma, conjunctivitis and dermatitis were obtained for the period of 2006 to 2010, for children ages <20 years old, for two large provinces around SIZ. Three exposure zones were defined on the basis of the distance from SIZ determined as: ≤5, >5 to 10, ≥20 km to represent high, intermediate and control exposure zones, respectively. Age-specific and gender-specific monthly counts of visits were modelled using generalised additive models controlling for time trends. The high and intermediate exposure zones were later combined together due to the similarity of associations. Exposure effect modification by age, gender and socioeconomic status (SES) was also tested.ResultsLiving within 10 km from SIZ showed a greater association with ARD (risk ratio (RR)=2.5; 95% CI=2.3 to 2.7), asthma (RR=3.7; 95% CI=3.1 to 4.5), conjunctivitis (RR=3.1; 95% CI=2.9 to 3.5) and dermatitis (RR=2.7; 95% CI=2.5 to 3.0) when compared with the control zone. No differences in associations were found for gender and SES groups; greater effects were noticed in the ≤14-year-old group for asthma.ConclusionsThis is the first study conducted in Oman to examine the health effects of a young population living near an industrial park. We hope that these findings will contribute in future developments of environmental health policies in Oman.
Fas Ligand Deficiency Impairs Tumor Immunity by Promoting an Accumulation of Monocytic Myeloid-Derived Suppressor Cells
Authors: Peyvandi Sanam , Buart Stéphanie , Samah Boubekeur , Vétizou Marie , Zhang Yanyan , Durrieu Ludovic , Polrot Mélanie , Chouaib Salem , Benihoud Karim , Louache Fawzia , Karray Saoussen 
Published: September 2015

AbstractThe Fas receptor ligand FasL regulates immune cell levels by inducing apoptosis of Fas receptor–positive cells. Here, we studied the impact of host FasL on tumor development in mice. Genetically targeting FasL in naïve mice increased myeloid cell populations, but, in marked contrast, it reduced the levels of myeloid-derived suppressor cells (MDSC) in mice bearing Lewis lung carcinoma tumors. Analysis of the MDSC subset distribution revealed that FasL deficiency skewed cell populations toward the M-MDSC subset, which displays a highly immunosuppressive activity. Furthermore, tumor-bearing mice that were FasL-deficient displayed an enhanced proportion of tumor-associated macrophages and regulatory T cells. Overall, the immunosuppressive environment produced by FasL targeting correlated with reduced survival of tumor-bearing mice. These results disclose a new role for FasL in modulating immunosuppressive cells. Cancer Res; 75(20); 4292–301. ©2015 AACR.
NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
Authors: Garcia-Rendueles Maria E.R. , Ricarte-Filho Julio C. , Untch Brian R. , Landa Iňigo , Knauf Jeffrey A. , Voza Francesca , Smith Vicki E. , Ganly Ian , Taylor Barry S. , Persaud Yogindra , Oler Gisele , Fang Yuqiang , Jhanwar Suresh C. , Viale Agnes , Heguy Adriana , Huberman Kety H. , Giancotti Filippo , Ghossein Ronald , Fagin James A. 
Published: September 2015

Abstract
Ch22q LOH is preferentially associated with RAS mutations in papillary and in poorly differentiated thyroid cancer (PDTC). The 22q tumor suppressor NF2, encoding merlin, is implicated in this interaction because of its frequent loss of function in human thyroid cancer cell lines. Nf2 deletion or Hras mutation is insufficient for transformation, whereas their combined disruption leads to murine PDTC with increased MAPK signaling. Merlin loss induces RAS signaling in part through inactivation of Hippo, which activates a YAP–TEAD transcriptional program. We find that the three RAS genes are themselves YAP–TEAD1 transcriptional targets, providing a novel mechanism of promotion of RAS-induced tumorigenesis. Moreover, pharmacologic disruption of YAP–TEAD with verteporfin blocks RAS transcription and signaling and inhibits cell growth. The increased MAPK output generated by NF2 loss in RAS-mutant cancers may inform therapeutic strategies, as it generates greater dependency on the MAPK pathway for viability.
Significance: Intensification of mutant RAS signaling through copy-number imbalances is commonly associated with transformation. We show that NF2/merlin inactivation augments mutant RAS signaling by promoting YAP/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK output and increased sensitivity to MEK inhibitors. Cancer Discov; 5(11); 1178–93. ©2015 AACR.
This article is highlighted in the In This Issue feature, p. 1111
Effect of High-Dose Statin Therapy on Drug-Eluting Stent Strut Coverage
Authors: Kim Jung-Sun , Kim Jeong Hun , Shin Dong-Ho , Kim Byeong-Keuk , Ko Young-Guk , Choi Donghoon , Jang Yangsoo , Hong Myeong-Ki 
Published: September 2015

Objective—
The influence of high-dose statin therapy on the serial stent healing process has not been fully investigated. Using optical coherence tomography, the effect of high-dose statin therapy on stent strut coverage was evaluated in drug-eluting stent–treated patients.

Approach and Results—

Sixty patients were randomly assigned to 2 groups according to the statin dose (atorvastatin 40 mg as high-dose statin therapy [n=29] versus pravastatin 20 mg as low-dose statin therapy [n=31]). Serial optical coherence tomographic evaluation post procedure and at the 3-month and 12-month follow-ups was performed in 50 patients with 54 stents (23 atorvastatin-treated patients versus 27 pravastatin-treated patients). The percentage of uncovered struts was defined as the ratio of uncovered struts/total struts. The primary end point was the percentage of uncovered struts at the 12-month follow-up. The secondary end point was the percentage of uncovered struts at the 3-month follow-up and the comparative percentage change (Δ) of uncovered struts at the 3- and 12-month follow-ups between the different dose statin therapies. The percentage of uncovered struts was 7.4% (range, 4.3%–10.4%) in atorvastatin-treated patients versus 10.6% (range, 5.7%–22.6%) in pravastatin-treated patients at the 3-month follow-up (
P
=0.13) and 1.3% (0.3%–3.8%) versus 2.5% (0.9%–9.7%), respectively, at the 12-month follow-up (
P
=0.01). The percentage Δ of uncovered struts from 3 to 12 months of follow-up was −7.9±8.5% in atorvastatin-treated patients versus −9.3±12.5% in pravastatin-treated patients (
P
=0.67).

Conclusions—
This study suggested that high-dose statin therapy might provide a beneficial effect for the vascular healing process after drug-eluting stent implantation.