bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low carbon multi-binder composite using lithomargic soil, biomass, and calcined seashell powder for sustainable bricks
Authors: Rao A. U. , Bhandary R. P. , Tantri Adithya , Narayana Sabhahit , Kamath Muralidhar 
Published: August 2024

AbstractBricks are manufactured using clays, which are fired at temperatures ranging from 1000 to 1200 °C. Due to the lack of quality clay, it is necessary to find alternate soils and waste materials for manufacturing bricks. The use of agricultural, aqua-cultural, and industrial wastes in the manufacturing of construction bricks leads to low-carbon material. This addresses the problem of agro-aqua-industrial waste disposal. The present study focuses on the utilization of biomass (BM) and slaked seashell powder (SSP) in compressed soil bricks made with locally available lithomargic soil (LS). The proposed soil bricks are prepared with 85% processed lithomargic soil, 12.5% biomass and 2.5% seashell powder. The reaction of multi-binder materials has been activated by one-part activation. The cast soil blocks are temperature cured at 100 °C, 250 °C, 500 °C & 750 °C to understand the effect of temperature on the hydration process of binder material. The compressed soil bricks are tested for compressive strength, initial rate of absorption, water absorption test, chloride content, sulphate content, microstructure analysis and thermal conductivity. The strength of soil bricks in bonding and in masonry, 3 prism and 4 prism tests were also conducted. Overall results indicate that bio-based alkali-activated brick masonry is superior for real-time adaptation because it reaches 10 MPa to 11.2 MPa compressive strength and 0.98 MPa to 1.2 MPa shear strength with curing at 500 °C.
A systematic literature review of education for Generation Alpha
Authors: Höfrová Alena , Balidemaj Venera , Small Mark A. 
Published: August 2024

AbstractGeneration Alpha are the first to grow up immersed in digital technology and presumed to be wired differently than previous generations. This systematic review synthesizes the research literature on what has been learned so far and broadly answers the following question: What is happening in the education and training of Generation Alpha? The literature review was conducted based on guidelines outlined by The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Titles of 2,093 studies, abstracts of 603 studies, and 335 full-text studies were evaluated for inclusion criteria. A total of 83 studies were included into the literature review. The studies were sorted into four major categories: (1) the role of teachers, (2) the role of new approaches to education, (3) the role of teaching tools, and (4) the role of blended/online learning. Despite frequent use of the term “Generation Alpha” in the research literature, relatively few studies report generational differences that reveal how children of this generation are characteristically different from previous generations. There is simply a strong assumption that Generation Alpha is different. A major concern is that the use of technology by Generation Alpha has decreased opportunities for social-emotional development and increased mental health problems. There are digital educational tools and online strategies being developed and tested but none have emerged to be dominant.
Association of Lifelines Diet Score (LLDS) with type 2 diabetes mellitus and hypertension among postmenopausal women: a cross-sectional study
Authors: Fateh Hawal Lateef 
Published: August 2024

Abstract
Background
The Lifelines Diet Score (LLDS), which adheres to the 2015 Dutch Dietary Guidelines, has not undergone testing yet, despite previous research indicating a potential link between diet quality and the occurrence of type 2 diabetes mellitus (T2DM) and hypertension (HTN). As such, this study was undertaken to explore the relationship between the Lifelines Diet Score (LLDS) and the prevalence of T2DM and HTN in postmenopausal women.

Method
1341 women, with an average age of 49.45 ± 14.65 years old, enrolled in this study. Anthropometric measurements, biochemical testing, and body composition was assessed using standardized procedures for each participant. Utilizing a validated and dependable 147-item food frequency questionnaire (FFQ), the Lifelines Diet Score (LLDS) was computed using 12 constituent elements. In addition to this, the estimations were determined through the application of both multiple and univariate logistic regression techniques.

Results
In healthy participants, the mean LLDS was 55.48 ± 4.28; in women with HTN, T2DM, or T2DM&HTN, the average LLDS was 27.37 ± 12.44, 26.47 ± 11.51, and 35.32 ± 5.74, respectively (P = 0.001). After adjusting for energy intake, age, carbohydrate, protein, fat, physical activity, and body mass index (BMI) the probability of developing HTN is 38% lower in the third tertile of LLDS than in the first tertile (OR = 0.62, CI 95% = 0.39–0.98) (P < 0.001). and 39% lower for developing T2DM (OR = 0.61, CI 95% = 0.35–0.99), (P < 0.001).

Conclusion
The results of this study revealed a correlation between LLDS and HTN, and T2DM, as well as the risk factors linked to these health conditions among postmenopausal women. Dietary adjustments are advisable for mitigating inflammation.
Literary Imaginations from Below: Crowdsourced Verse and African Literature’s Digital Publics
Authors: Adeoba ‘Gbenga 
Published: August 2024

AbstractWhat could be called a digital turn has amplified conversations around publics, literary cultures, and African literature’s broadened genres. Drawing on conceptual frameworks and debates from literary, cultural, and media studies, Adeoba examines the literary imaginations and ekphrastic practices that emerge from the digital cultures of African Twitter users. Adeoba argues that crowdsourced verse demonstrates the creative agency of digitally connected everyday people and newer modes of sociality enabled by African poetry in digital contexts. Crowdsourced verse presents opportunities to examine the digital publics of African literature and their contributions to the body of literary works circulating in digital spaces.
European human rights law and the legality of sex offence prosecutions based on deception as to gender history
Authors: Sharpe Alex 
Published: August 2024

AbstractThis paper considers the legality of the UK practice of prosecuting trans people for sexual offences on the basis of deception as to gender history, a practice unknown in other member states. It argues that such prosecutions may constitute an unjustified violation of Article 8 of the European Convention on Human Rights. Moreover, it argues that where criminal prosecution falls within the scope of Article 8 but is viewed as objectively justified under Article 8(2), it may constitute a violation of Article 14. The paper will proceed as follows. Part 2 will provide some background context regarding prosecution of trans people for deception as to gender history in the UK. Part 3 will set out the current law pertaining to sexual fraud in England and Wales. Part 4 will present two arguments as to why prosecutions based on current English law, or Crown Prosecution Service interpretations of it, may violate Article 8: (1) a right to respect for privacy is undermined by lack of legal certainty regarding the threshold of criminal liability; and (2) deception as to gender history ought not to be considered a material deception serving to vitiate consent as a matter of law. Part 5 will consider the issue of potential discrimination under Article 14.
Control of breathing in preterm infants on incubator oxygen or nasal cannula oxygen
Authors: Travers Colm P. , Chahine Rouba , Nakhmani Arie , Aban Inmaculada , Carlo Waldemar A. , Ambalavanan Namasivayam 
Published: August 2024

Abstract
Background
Incubator oxygen may improve respiratory stability in preterm infants compared with nasal cannula oxygen.

Methods
Single center randomized trial of infants <29 weeks’ gestation on supplemental oxygen at ≥32 weeks’ postmenstrual age. Infants were crossed-over every 24 hours for 96 hours between incubator oxygen and nasal cannula ≤1.0 L/kg/min. We measured episodes of intermittent hypoxemia (oxygen saturations (SpO2) < 85% ≥10 seconds), bradycardia, cerebral and abdominal hypoxemia, and end-tidal carbon dioxide.

Results
We enrolled 25 infants with a gestational age of 26 weeks 4 days±15 days (mean ± SD) and birth weight 805 ± 202 grams. There were no differences in episodes of intermittent hypoxemia, bradycardia, or cerebral hypoxemia between groups. There were fewer episodes of abdominal hypoxemia <40% ≥10 seconds with incubator oxygen compared with nasal cannula (132 ± 130 versus 158 ± 125; p < 0.01). Time with SpO2 < 85% and abdominal hypoxemia was lower among infants on incubator oxygen. Carbon dioxide values were higher while on incubator oxygen (41 ± 11 versus 36 ± 10 mmHg; p < 0.02).

Conclusion
There was no difference in intermittent hypoxemia between incubator and nasal cannula oxygen among preterm infants on supplemental oxygen. Infants had higher levels of carbon dioxide while on incubator oxygen, which may have improved some measures of respiratory stability.

ClincalTrials.gov identifiers
NCT03333174 and NCT03174301.

Impact Statement

In this randomized cross-over trial of preterm infants on supplemental oxygen, incubator oxygen did not decrease episodes of intermittent hypoxemia compared with nasal cannula oxygen. Incubator oxygen reduced time with oxygen saturations less than 85%, reduced abdominal hypoxemia, and increased carbon dioxide levels.

Differences in measures of respiratory stability on incubator oxygen may be partly due to higher carbon dioxide levels compared with nasal cannula oxygen.

The mode of supplemental oxygen administration may impact control of breathing in preterm infants through its effect on hypopharyngeal oxygen stability and carbon dioxide levels.
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
Authors: Zhang Tao , Pan Zilu , Gao Jing , Wu Qingqing , Bai Gang , Li Yan , Tong Linjiang , Feng Fang , Lai Mengzhen , Liu Yingqiang , Song Peiran , Ning Yi , Tang Haotian , Luo Wen , Chen Yi , Fang Yan , Zhang Hui , Liu Qiupei , Zhang Yudi , Wang Hua , Chen Zhiwei , Chen Yi , Geng Meiyu , Ji Hongbin , Zhao Guilong , Zhou Hu , Ding Jian , Xie Hua 
Published: August 2024

AbstractThird-generation EGFR tyrosine kinase inhibitors (TKIs), exemplified by osimertinib, have demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer (NSCLC). Our previous work has identified ASK120067 as a novel third-generation EGFR TKI with remarkable antitumor effects that has undergone New Drug Application (NDA) submission in China. Despite substantial progress, acquired resistance to EGFR-TKIs remains a significant challenge, impeding the long-term effectiveness of therapeutic approaches. In this study, we conducted a comprehensive investigation utilizing high-throughput proteomics analysis on established TKI-resistant tumor models, and found a notable upregulation of branched-chain amino acid transaminase 1 (BCAT1) expression in both osimertinib- and ASK120067-resistant tumors compared with the parental TKI-sensitive NSCLC tumors. Genetic depletion or pharmacological inhibition of BCAT1 impaired the growth of resistant cells and partially re-sensitized tumor cells to EGFR TKIs. Mechanistically, upregulated BCAT1 in resistant cells reprogrammed branched-chain amino acid (BCAA) metabolism and promoted alpha ketoglutarate (α-KG)-dependent demethylation of lysine 27 on histone H3 (H3K27) and subsequent transcriptional derepression of glycolysis-related genes, thereby enhancing glycolysis and promoting tumor progression. Moreover, we identified WQQ-345 as a novel BCAT1 inhibitor exhibiting antitumor activity both in vitro and in vivo against TKI-resistant lung cancer with high BCAT1 expression. In summary, our study highlighted the crucial role of BCAT1 in mediating resistance to third-generation EGFR-TKIs through epigenetic activation of glycolysis in NSCLC, thereby supporting BCAT1 as a promising therapeutic target for the treatment of TKI-resistant NSCLC.
Comparing transplant outcomes in ALL patients after myeloablative conditioning in mismatch-related or unrelated donor settings
Authors: Otoukesh Salman , Yang Dongyun , Mokhtari Sally , Pourhassan Hoda , Agrawal Vaibhav , Arslan Shukaib , Amanam Idoroenyi , Ball Brian , Koller Paul , Salhotra Amandeep , Sandhu Karamjeet , Aribi Ahmed , Artz Andrew , Aldoss Ibrahim , Pullarkat Vinod , Ali Haris , Blackmon Amanda , Becker Pamela , Curtin Peter , Stewart Forrest , Smith Eileen , Stein Anthony , Marcucci Guido , Forman Stephen J. , Nakamura Ryotaro , Al Malki Monzr M. 
Published: August 2024

AbstractThe optimal myeloablative conditioning regimen for ALL patients undergoing hematopoietic cell transplant (HCT) with an alternative donor is unknown. We analyzed HCT outcomes ALL patients (n = 269) who underwent HCT at our center from 2010 to 2020 in complete remission (CR) after FTBI-etoposide and CNI-based GvHD prophylaxis for matched donor HCT (ETOP-package; n = 196) or FTBI-Fludarabine and post-transplant cyclophosphamide (PTCy)-based prophylaxis for HLA- mismatched (related or unrelated) donors (FLU-package; n = 64). Patients in FLU-package showed a significant delay in engraftment (p < 0.001) and lower cumulative incidence (CI) of any and extensive chronic GVHD (p = 0.009 and 0.001, respectively). At the median follow up of 4.6 years (range 1–12 years); non-relapse mortality, overall or leukemia-free survival and GVHD-free/relapse-free survival were not significantly impacted by the choice of conditioning. However, in patients at CR2 or with measurable residual disease (MRD+), there was a trend towards higher relapse after FLU-package (p = 0.08 and p = 0.07, respectively), while patients at CR1 regardless of MRD status had similar outcomes despite the package/donor type (p = 0.9 and 0.7, respectively). Our data suggests that FLU-package for alternative donors offers comparable outcomes to ETOP-package for matched donor HCT to treat ALL. Disease status and depth of remission at HCT were independent predictors for better outcomes.
Deep learning for detecting and characterizing oil and gas well pads in satellite imagery
Authors: Ramachandran Neel , Irvin Jeremy , Omara Mark , Gautam Ritesh , Meisenhelder Kelsey , Rostami Erfan , Sheng Hao , Ng Andrew Y. , Jackson Robert B. 
Published: August 2024

AbstractMethane emissions from the oil and gas sector are a large contributor to climate change. Robust emission quantification and source attribution are needed for mitigating methane emissions, requiring a transparent, comprehensive, and accurate geospatial database of oil and gas infrastructure. Realizing such a database is hindered by data gaps nationally and globally. To fill these gaps, we present a deep learning approach on freely available, high-resolution satellite imagery for automatically mapping well pads and storage tanks. We validate the results in the Permian and Denver-Julesburg basins, two high-producing basins in the United States. Our approach achieves high performance on expert-curated datasets of well pads (Precision = 0.955, Recall = 0.904) and storage tanks (Precision = 0.962, Recall = 0.968). When deployed across the entire basins, the approach captures a majority of well pads in existing datasets (79.5%) and detects a substantial number (>70,000) of well pads not present in those datasets. Furthermore, we detect storage tanks (>169,000) on well pads, which were not mapped in existing datasets. We identify remaining challenges with the approach, which, when solved, should enable a globally scalable and public framework for mapping well pads, storage tanks, and other oil and gas infrastructure.
Neutral beam microscopy with a reciprocal space approach using magnetic beam spin encoding
Authors: Lowe Morgan , Alkoby Yosef , Chadwick Helen , Alexandrowicz Gil 
Published: August 2024

AbstractThe emerging technique of neutral beam microscopy offers a non-perturbative way of imaging surfaces of various materials which cannot be studied using conventional microscopes. Current neutral beam microscopes use either diffractive focusing or pin-hole scanning to achieve spatial resolution, and are characterised by a strong dependence of the imaging time on the required resolution. In this work we introduce an alternative method for achieving spatial resolution with neutral atom beams which is based on manipulating the magnetic moments of the beam particles in a gradient field, and is characterised by a much weaker dependence of the imaging time on the image resolution. The validity of the imaging approach is demonstrated experimentally by reconstructing one dimensional profiles of the beam which are in good agreement with numerical simulation calculations. Numerical simulations are used to demonstrate the dependence of the signal to noise on the scan resolution and the topography of the sample, and assess the broadening effect due to the spread of velocities of the beam particles. The route towards implementing magnetic encoding in high resolution microscopes is discussed.
Geologically constrained 2-million-year-long simulations of Antarctic Ice Sheet retreat and expansion through the Pliocene
Authors: Halberstadt Anna Ruth W. , Gasson Edward , Pollard David , Marschalek James , DeConto Robert M. 
Published: August 2024

AbstractPliocene global temperatures periodically exceeded modern levels, offering insights into ice sheet sensitivity to warm climates. Ice-proximal geologic records from this period provide crucial but limited glimpses of Antarctic Ice Sheet behavior. We use an ice sheet model driven by climate model snapshots to simulate transient glacial cyclicity from 4.5 to 2.6 Ma, providing spatial and temporal context for geologic records. By evaluating model simulations against a comprehensive synthesis of geologic data, we translate the intermittent geologic record into a continuous reconstruction of Antarctic sea level contributions, revealing a dynamic ice sheet that contributed up to 25 m of glacial-interglacial sea level change. Model grounding line behavior across all major Antarctic catchments exhibits an extended period of receded ice during the mid-Pliocene, coincident with proximal geologic data around Antarctica but earlier than peak warmth in the Northern Hemisphere. Marine ice sheet collapse is triggered with 1.5 °C model subsurface ocean warming.
Radiative plasma simulations of black hole accretion flow coronae in the hard and soft states
Authors: Nättilä Joonas 
Published: August 2024

AbstractStellar-mass black holes in x-ray binary systems are powered by mass transfer from a companion star. The accreted gas forms an accretion disk around the black hole and emits x-ray radiation in two distinct modes: hard and soft state. The origin of the states is unknown. We perform radiative plasma simulations of the electron-positron-photon corona around the inner accretion flow. Our simulations extend previous efforts by self-consistently including all the prevalent quantum electrodynamic processes. We demonstrate that when the plasma is turbulent, it naturally generates the observed hard-state emission. In addition, we show that when soft x-ray photons irradiate the system—mimicking radiation from an accretion disk—the turbulent plasma transitions into a new equilibrium state that generates the observed soft-state emission. Our findings demonstrate that turbulent motions of magnetized plasma can power black-hole accretion flow coronae and that quantum electrodynamic processes control the underlying state of the plasma.
Low-symmetry vacancy-related spin qubit in hexagonal boron nitride
Authors: Babar Rohit , Barcza Gergely , Pershin Anton , Park Hyoju , Bulancea Lindvall Oscar , Thiering Gergő , Legeza Örs , Warner Jamie H. , Abrikosov Igor A. , Gali Adam , Ivády Viktor 
Published: August 2024

AbstractPoint defect qubits in semiconductors have demonstrated their outstanding capabilities for high spatial resolution sensing generating broad multidisciplinary interest. Hexagonal boron nitride (hBN) hosting point defect qubits have recently opened up new horizons for quantum sensing by implementing sensing foils. The sensitivity of point defect sensors in hBN is currently limited by the linewidth of the magnetic resonance signal, which is broadened due to strong hyperfine couplings. Here, we report on a vacancy-related spin qubit with an inherently low symmetry configuration, the VB2 center, giving rise to a reduced magnetic resonance linewidth at zero magnetic fields. The VB2 center is also equipped with a classical memory that can be utilized for storing population information. Using scanning transmission electron microscopy imaging, we confirm the existence of the VB2 configuration in free-standing monolayer hBN.
Current challenges of alternative proteins as future foods
Authors: Malila Yuwares , Owolabi Iyiola O. , Chotanaphuti Tanai , Sakdibhornssup Napat , Elliott Christopher T. , Visessanguan Wonnop , Karoonuthaisiri Nitsara , Petchkongkaew Awanwee 
Published: August 2024

Abstract
Global demand for food is expected to nearly double by 2050. Alternative proteins (AP) have been proposed as a sustainable solution to provide food security as natural resources become more depleted. However, the growth and consumer intake of AP remains limited. This review aims to better understand the challenges and environmental impacts of four main AP categories: plant-based, insect-based, microbe-derived, and cultured meat and seafood. The environmental benefits of plant-based and insect-based proteins have been documented but the impacts of microbe-derived proteins and cultured meat have not been fully assessed. The development of alternative products with nutritional and sensory profiles similar to their conventional counterparts remains highly challenging. Furthermore, incomplete safety assessments and a lack of clear regulatory guidelines confuse the food industry and hamper progress. Much still needs to be done to fully support AP utilization within the context of supporting the drive to make the global food system sustainable.
Entinostat as a combinatorial therapeutic for rhabdomyosarcoma
Authors: Chauhan Shefali , Lian Emily , Habib Iman , Liu Qianqian , Anders Nicole M. , Bugg Megan M. , Federman Noah C. , Reid Joel M. , Stewart Clinton F. , Cates Tristan , Michalek Joel E. , Keller Charles 
Published: August 2024

AbstractRhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. For the alveolar subtype (ARMS), the presence of the PAX3::FOXO1 fusion gene and/or metastases are strong predictors of poor outcome. Metastatic PAX3::FOXO1+ ARMS often responds to chemotherapies initially, only to subsequently relapse and become resistant with most patients failing to survive beyond 8 years post-diagnosis. No curative intent phase II or phase III clinical trial has been available for patients in the past 10 years (ARST0921). Thus, metastatic ARMS represents a significantly unmet clinical need. Chemotherapy resistance in ARMS has previously been attributed to PAX3::FOXO1-mediated cell cycle checkpoint adaptation, which is mediated by an HDAC3-SMARCA4-miR-27a-PAX3::FOXO1 circuit that can be disrupted by HDAC3 inhibition. In this study, we investigated the therapeutic efficacy of combining the epigenetic regulator entinostat, a Class I Histone Deacetylase (HDAC1-3) inhibitor, with RMS-specific chemotherapies in patient derived xenograft (PDX) models of RMS. We identified single agent, additive or synergistic relationships between relapse-specific chemotherapies and clinically relevant drug exposures of entinostat in three PAX3::FOXO1+ ARMS mouse models. This preclinical data provides further rationale for clinical investigation of entinostat, already known to be well tolerated in a pediatric phase I clinical trial (ADVL1513).