bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: New Preparation of Benzylic Manganese Chlorides by the Direct Insertion of Magnesium into Benzylic Chlorides in the Presence of MnCl2·2LiCl.
Authors: Quinio Pauline , Benischke Andreas D. , Moyeux Alban , Cahiez Gerard , Knochel Paul 
Published: July 2015

AbstractReactions of the new, conveniently prepared benzylic manganese reagents with aldehydes (II), acid chlorides (V), aryl bromides (VII) as well as nitrostyrene (IX) proceed without any additional transition metal.
ChemInform Abstract: Synthesis of Active Tin: An Efficient Reagent for Allylation Reaction of Carbonyl Compounds.
Authors: Sinha Arun Kumar , Sil Amit , Sasmal Anup Kumar , Pradhan Mukul , Pal Tarasankar 
Published: July 2015

AbstractHomoallylic alcohols (III), (V) are obtained by allylation of the various substituted aldehydes or ketones using high purity Sn(0) as catalyst.
ChemInform Abstract: Copper‐Catalyzed Enantioselective Propargylic Etherification of Propargylic Esters with Alcohols.
Authors: Nakajima Kazunari , Shibata Masashi , Nishibayashi Yoshiaki 
Published: July 2015

AbstractA copper‐catalyzed enantioselective propargylic etherification of propargylic carbonates with simple alcohols and phenols is developed to provide propargylic ethers in good to excellent enantioselectivities.
ChemInform Abstract: Palladium(II)‐Catalyzed Highly Enantioselective C—H Arylation of Cyclopropylmethylamines.
Authors: Chan Kelvin S. L. , Fu Hai‐Yan , Yu Jin‐Quan 
Published: July 2015

AbstractThe reaction conditions allow the preparation of a broad spectrum of cis‐configurated target compounds.
ChemInform Abstract: Tricyclic Fused Pyrazoles with a ′Click′ 1,2,3‐Triazole Substituent in Position 3 are Nanomolar CB1 Receptor Ligands.
Authors: Zanato Chiara , Cascio Maria Grazia , Lazzari Paolo , Pertwee Roger , Testa Andrea , Zanda Matteo 
Published: July 2015

AbstractStarting from 3‐bromo benzaldehyde, an eleven step synthesis of the substrate (I) is described which is further transformed to the title compounds.
ChemInform Abstract: Synthesis of Tetrasubstituted Propargylamines from Cyclohexanone by Solvent‐Free Copper(II) Catalysis.
Authors: Palchak Zachary L. , Lussier Daniel J. , Pierce Conor J. , Larsen Catharine H. 
Published: July 2015

AbstractCu(II)‐catalyzed three‐component coupling of cyclohexanone with amines and alkynes produces tetrasubstituted propargylamines in good yields.
ChemInform Abstract: Taming Chlorine Azide: Access to 1,2‐Azidochlorides from Alkenes.
Authors: Valiulin Roman A. , Mamidyala Sreeman , Finn M. G. 
Published: July 2015

AbstractA biphasic media in the presence of olefinic compounds dissolved in the organic layer or in the absence of an organic layer avoids the formation of the explosive gaseous ClN3.
ChemInform Abstract: Visible Light‐Mediated Arylalkylation of Allylic Alcohols Through Concomitant 1,2‐Aryl Migration.
Authors: Huang Hong‐Li , Yan Hang , Yang Chao , Xia Wujiong 
Published: July 2015

AbstractThe title reaction provides the synthesis of α‐aryl‐β‐alkylated ketones via 1,2‐aryl migration from aryl allylic alcohols.
ChemInform Abstract: Copper Catalyzed Amidation of Aryl Halides Through Chelation Assistance.
Authors: Kathiravan Subban , Ghosh Shishir , Hogarth Graeme , Nicholls Ian A. 
Published: July 2015

AbstractA new general and straightforward chelation‐assisted, copper‐mediated amidation of weakly activated arylbromides with 8‐aminoquinoline derivatives is developed.
ChemInform Abstract: Nickel‐Catalyzed Direct Thioetherification of β‐C(sp3)—H Bonds of Aliphatic Amides.
Authors: Lin Cong , Yu Wenlong , Yao Jinzhong , Wang Bingjie , Liu Zhanxiang , Zhang Yuhong 
Published: July 2015

AbstractA simple procedure is elaborated for the nickel‐catalyzed aminoquinolinyl‐assisted thioetherification of propioamides (I) and (VI).
ChemInform Abstract: Electron‐Deficient Heteroarenium Salts: An Organocatalytic Tool for Activation of Hydrogen Peroxide in Oxidations.
Authors: Sturala Jiri , Bohacova Sona , Chudoba Josef , Metelkova Radka , Cibulka Radek 
Published: July 2015

AbstractA broad spectrum of mono‐ and disubstituted heteroarenium salts, mostly as triflates, is prepared and tested in a sulfoxidation process.
ChemInform Abstract: Four‐Component Reaction Leading to Highly Functionalized Sulfoalkoxy Carbonyl Compounds.
Authors: Sohail Muhammad , Zhang Yixin , Sun Guangwei , Guo Xin , Liu Wujun , Liu Chang , Zhao Zongbao K. 
Published: July 2015

AbstractA facile regio‐ and diastereoselective four‐component reaction of α,β‐unsaturated carbonyl compounds, a cyclic ether, a sulfonic acid, and a halogen reagent is developed under mild conditions to access α‐bromo‐β‐sulfoalkoxyl carbonyl derivatives with excellent trans‐selectivity.
ChemInform Abstract: A Metal‐Free and Recyclable Synthesis of Benzothiazoles Using Thiourea as a Sulfur Surrogate.
Authors: Yin Yan , Zhou Hong , Liu Xichen , Chen Haiying , Wu Fanhong , Zhang Heng , Tao Ruiheng , Cheng Fengkai , Feng Yangbo 
Published: July 2015

AbstractTreatment of substrates (I) with thiourea and TFA gives benzothiazoles (IV) and TFA salts (V).
ChemInform Abstract: H6P2W18O62/Nanoclinoptilolite as an Efficient Nanohybrid Catalyst in the Cyclotrimerization of Aryl Methyl Ketones under Solvent‐Free Conditions.
Authors: Tayebee R. , Jarrahi M. 
Published: July 2015

AbstractA newly synthesized heterogeneous nanohybrid material is applied in the synthesis of various 1,3,5‐triaryl benzenes (II).
ChemInform Abstract: Derivatives of α,α‐Aryl Naphthalimide Nitriles as Fluoride Ion Sensors: Convenient Precursors for the Synthesis of Aryl Naphthalimide Ketones.
Authors: Chen Jinju , Liu Chuanxiang , Guan Fengjie , Zhang Chuanxiu , Ji Kai , Wang Xinyu , Xu Min , Wu Fanhong 
Published: July 2015

Abstractα,α‐Aryl naphthalimide nitriles (III) are efficiently obtained by a SNAr procedure involving the displacement of activated naphthalimide bromides (I) with the anions of substituted aryl acetonitriles (II).
ChemInform Abstract: Synthesis of Dibenzo[b,d]furans Through One‐Pot Cascade Reactions of 1‐Arylpenta‐3,4‐dien‐2‐ones with Activated Ketones.
Authors: He Yan , Guo Shenghai , Zhang Xinying , Guo Chenhao , Fan Xuesen 
Published: July 2015

AbstractFunctionalized dibenzo[b,d]furans are successfully obtained through a new cascade process including Michael addition, intramolecular aldol condensation, and copper‐catalyzed C—H activation.
ChemInform Abstract: Diastereoselective Synthesis of Substituted Tetrahydrothiophenes and ‐thiopyrans via Thia‐Prins Cyclization Reaction.
Authors: Borah Madhurjya , Gogoi Paramartha , Indukuri Kiran , Saikia Anil K. 
Published: July 2015

AbstractThioacrylates are used as starting materials in the highly diastereoselective title reaction.
ChemInform Abstract: Cocamidopropyl Betaine Catalyzed Benzoin Condensation and Pseudo‐Four‐Component Reaction of the in situ Formed Benzoin in Water.
Authors: Tamaddon Fatemeh , Alizadeh Masoomeh 
Published: July 2015

AbstractThe zwitterionic surfactant catalyzed synthesis of tetrasubstituted pyrroles (IV) via the generation of benzoins (II) from aldehydes (I) and their condensation with 1,3‐dicarbonyl compounds (III) is reported.
ChemInform Abstract: Ruthenium‐Catalyzed C—C Coupling of Amino Alcohols with Dienes via Transfer Hydrogenation: Redox‐Triggered Imine Addition and Related Hydroaminoalkylations.
Authors: Chen Te‐Yu , Tsutsumi Ryosuke , Montgomery T. Patrick , Volchkov Ivan , Krische Michael J. 
Published: July 2015

Abstract4‐Aminobutanol (II) and some related amino alcohols such as (X) can be used in the title reaction.
ChemInform Abstract: Brucine Diol—Copper‐Catalyzed Asymmetric Synthesis of endo‐Pyrrolidines: The Mechanistic Dichotomy of Imino Esters.
Authors: Li Jian‐Yuan , Kim Hun Young , Oh Kyungsoo 
Published: July 2015

AbstractA concerted pathway for the endo‐selective [3 + 2]‐cycloaddition of methyl imino ester with nitroalkenes is developed.
ChemInform Abstract: An Organocatalytic Mannich/Denitration Reaction for the Asymmetric Synthesis of 3‐Ethylacetate‐Substitued 3‐Amino‐2‐oxindoles: Formal Synthesis of AG‐041R.
Authors: Zhao Kun , Shu Tao , Jia Jiaqi , Raabe Gerhard , Enders Dieter 
Published: July 2015

AbstractA variety of title compounds is available with moderate to good yields and excellent enantioselectivity as intermediates of pyrroloindoline alkaloids.
ChemInform Abstract: Efficient Direct 2,2,2‐Trifluoroethylation of Indoles via C—H Functionalization.
Authors: Tolnai Gergely L. , Szekely Anna , Mako Zita , Gati Tamas , Daru Janos , Bihari Tamas , Stirling Andras , Novak Zoltan 
Published: July 2015

AbstractIf 3‐methylindole is used as starting material, formation of any trifluoroethylated product is not observed.
ChemInform Abstract: Cascade Arylalkylation of Activated Alkenes: Synthesis of Chloro‐ and Cyano‐Containing Oxindoles.
Authors: Li Xueqin , Xu Jian , Gao Yuzhen , Fang Hua , Tang Guo , Zhao Yufen 
Published: July 2015

AbstractThe oxidative cyclization is carried out in dichloromethane or acetonitrile to produce the desired oxindole structures bearing a functionalized side chain at position 3.
ChemInform Abstract: Gold‐Catalyzed Multiple Cascade Reaction of 2‐Alkynylphenylazides with Propargyl Alcohols.
Authors: Li Nan , Wang Tian‐Yi , Gong Liu‐Zhu , Zhang Liming 
Published: July 2015

AbstractThe title reaction allows the step‐economical synthesis of pyrroloindolone derivatives, such as (III), (VI), and (VIII), with a wide range of structural diversity.
ChemInform Abstract: Copper(I)‐Promoted Trifluoromethylation of Indole Derivates with Concomitant C—C Bond Formation to Access Fused Tricyclic Indoles.
Authors: Zhu Huiming , Liu Huanlong , Feng Xiaolong , Guo Ruixia , Chen Xueyan , Pan Zhenhua , Zhang Lantong 
Published: July 2015

AbstractThe trifluoromethylation/cyclization sequence exhibits excellent functional‐group tolerance to provide functionalized fused tricyclic indole derivatives in good yields.
ChemInform Abstract: I2—DMSO—PTSA: A Simple and Metal Free Oxidative Cross Coupling of Imidazo[1,2‐a]pyridines and Methylketones.
Authors: Chennapuram Madhu , Emmadi Narender Reddy , Bingi Chiranjeevi , Atmakur Krishnaiah 
Published: July 2015

AbstractVarious aryl(phenylimidazo[1,2‐a]pyridinyl)ethanediones are selectively obtained with a new C—C bond formation via Kornblum oxidation followed by nucleophilic attack of a imidazo[1,2‐a]pyridine on the in situ generated phenylglyoxal.
ChemInform Abstract: Copper‐Catalyzed Direct Amination of Benzoxazoles Using Primary Amines as Nitrogen Sources.
Authors: Gu Jian , Cai Chun 
Published: July 2015

AbstractA variety of substituted aminobenzoxazoles is efficiently and smoothly obtained by direct C—H amination of benzoxazoles with primary amines through copper‐catalyzed C—H bond activation using tBuOOH as oxidant.
ChemInform Abstract: Facile Azide Formation via Diazotransfer Reaction in a Copper Tube Flow Reactor.
Authors: Nuyts Koen , Ceulemans Matthias , Parac‐Vogt Tatjana N. , Bultynck Geert , De Borggraeve Wim M. 
Published: July 2015

AbstractThe conversion of primary amines into organic azides using AZS as the azide source is catalyzed by copper from the copper tube flow reactor.
ChemInform Abstract: A Straightforward and Versatile Approach to the Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles from Alkyl Halides via a One‐Pot, Three‐Component Reaction.
Authors: Gonzalez‐Calderon Davir , Aguirre‐De Paz Jose G. , Gonzalez‐Gonzalez Carlos A. , Fuentes‐Benites Aydee , Gonzalez‐Romero Carlos 
Published: July 2015

AbstractA convenient one‐pot procedure for the [3 + 2] cycloaddition reaction of in situ generated organic azides with enolates to produce triazoles in good yields is presented.
ChemInform Abstract: Ruthenium‐Catalyzed Synthesis of 5‐Amino‐1,2,3‐triazole‐4‐carboxylates for Triazole‐Based Scaffolds: Beyond the Dimroth Rearrangement.
Authors: Ferrini Serena , Chandanshive Jay Zumbar , Lena Stefano , Comes Franchini Mauro , Giannini Giuseppe , Tafi Andrea , Taddei Maurizio 
Published: July 2015

AbstractSome N‐Boc ynamides bearing a terminal ester or aryl group are treated with azides to produce the desired triazoles with complete regiocontrol.
ChemInform Abstract: Supramolecular Catalysis in the Synthesis of Substituted 1H‐Tetrazoles from Isonitriles by a Self‐Assembled Hexameric Capsule.
Authors: Giust Sonia , La Sorella Giorgio , Sperni Laura , Fabris Fabrizio , Strukul Giorgio , Scarso Alessandro 
Published: July 2015

AbstractThe synthesis of substituted 1H‐tetrazoles from aliphatic or aromatic isonitriles and trimethylsilyl azide can be efficiently promoted by the hexameric capsule of resorcin[4]arene as a supramolecular self‐assembled catalyst.
ChemInform Abstract: Triflic Acid Mediated Cascade Cyclization of Aryldiynes for the Synthesis of Indeno[1,2‐c]chromenes: Application to Dye‐Sensitized Solar Cells.
Authors: Jin Tienan , et al.  
Published: July 2015

AbstractSubstrates bearing an ortho‐anisole substituent are transformed to the heterocyclic title scaffold in the presence of TfOH (mechanism).
ChemInform Abstract: Palladium‐Catalyzed Oxidative Carbamoylation of Isoquinoline N‐Oxides with Formylamides by Means of Dual C—H Oxidative Coupling.
Authors: Yao Bo , Deng Chen‐Liang , Liu Yan , Tang Ri‐Yuan , Zhang Xing‐Guo , Li Jin‐Heng 
Published: July 2015

AbstractThe first examples for the carbamoylation of isoquinoline N‐oxides with formylamides furnishing isoquinoline‐1‐carboxamides such as (III) and (V) in moderate to good yields are given.
ChemInform Abstract: Copper‐Mediated Synthesis of Pyrazolo[1,5‐a]pyridines Through Oxidative Linkage of C—C/N—N Bonds.
Authors: Mohan Darapaneni Chandra , Ravi Chitrakar , Rao Sadu Nageswara , Adimurthy Subbarayappa 
Published: July 2015

AbstractPyrazolopyridinecarboxylates are furnished under mild conditions from commercially available pyridyl ester and benzonitriles.
ChemInform Abstract: Selective Hydrogenation of Indolizines: An Expeditious Approach to Derive Tetrahydroindolizines and Indolizidines from Morita—Baylis—Hillman Adducts.
Authors: Teodoro Bruno V. M. , Correia Jose Tiago M. , Coelho Fernando 
Published: July 2015

AbstractThe starting adducts are prepared according to a literature procedure and cyclized to the required indolizine substrates following an optimized procedure [cf.
ChemInform Abstract: A One‐Pot, Catalyst‐Free Synthesis of Novel 2‐Thioxo‐Tetrahydropyrimidine Derivatives via the Three‐Component Reaction of Alkyl Chloroglyoxalates, Alkyl Isocyanides, and Thioureas.
Authors: Moradi Loghman , Bahrami Chonor , Mirzaei Anvar , Zarehbin Mohammad Rezgar , Yavari Issa 
Published: July 2015

AbstractThe reaction between alkyl isocyanides, ethyl chloroglyoxalate, and thiourea derivatives provides a simple one‐pot approach for the synthesis of novel thioxopyrimidine derivatives.
ChemInform Abstract: Copper(I) Carboxylate Catalyzed C—N Coupling of 2‐Amino Pyrimidines with Aryl Halides to Selectively Generate Secondary and Tertiary Amines.
Authors: Zhang Yue , Quan Zheng‐Jun , Gong Hai‐Peng , Da Yu‐Xia , Zhang Zhang , Wang Xi‐Cun 
Published: July 2015

AbstractIt is found that potassium phosphate used as base favors the formation of secondary amines (III), (VI), whereas tertiary amines (IV),(VII) are obtained when tBuONa is used.
ChemInform Abstract: An Efficient One‐Pot Synthesis of 2‐Bromo‐6‐aryl[5H]pyrrolo[2,3‐b]pyrazines.
Authors: Simpson Iain , St‐Gallay Steve A. , Stokes Stephen , Whittaker David T. E. , Wiewiora Rafal 
Published: July 2015

AbstractA new two step one‐pot method for the synthesis of the title compounds is described.
ChemInform Abstract: Synthesis and Selective Functionalization of [1,2,4]Triazolo‐[4,3‐a]pyrazines.
Authors: Demmer Charles S. , Joergensen Morten , Kehler Jan , Bunch Lennart , Rasmussen Lars K. 
Published: July 2015

AbstractA short synthesis of 8‐chloro[1,2,4]triazolo‐[4,3‐a]pyrazines (III) using a two‐step, one‐pot oxidative cyclization method is reported.
ChemInform Abstract: anti‐Selective Vicinal Silaboration and Diboration of Alkynoates Through Phosphine Organocatalysis.
Authors: Nagao Kazunori , Ohmiya Hirohisa , Sawamura Masaya 
Published: July 2015

AbstractThe formed E‐borylsilyl olefines are further functionalized by palladium catalyzed coupling reactions.
ChemInform Abstract: Copper‐Catalyzed Radical Cascade Cyclization for the Synthesis of Phosphorated Indolines.
Authors: Zhang Hong‐Yu , Mao Liu‐Liang , Yang Bin , Yang Shang‐Dong 
Published: July 2015

AbstractTitle compounds (III) and (V) are prepared by a Cu‐catalyzed amino‐phosphorous difunctionalization via cascade cyclization.
ChemInform Abstract: Arylation of Allylphosphonates and Application to the Preparation of Phosphonomethyl‐Coumarin, ‐Quinolinone and ‐Benzoxepinone Skeletons.
Authors: Abdelli Abderrahmen , Gaucher Anne , Efrit Mohamed Lotfi , M'rabet Hedi , Prim Damien 
Published: July 2015

AbstractThe Pd‐catalyzed arylation of ester (II) followed by intramolecular cyclization of arylallylphosphonate intermediates affords the title compounds in a one‐pot manner.
ChemInform Abstract: Noble Synthesis of Xanthene‐Based Dyes by Copper‐Catalyzed Azide—Alkyne Cycloaddition Reaction.
Authors: Shin Dong Geun , Kim Min Xoung , Yi Whikun , Han Jin Wook 
Published: July 2015

AbstractA new type of small organic dyes based on the xanthene skeleton are synthesized evaluated for their absorbance and fluorescence properties.
ChemInform Abstract: New Clerodane Diterpenoids from the Twigs and Leaves of Croton euryphyllus
Authors: Pan Zhenghong , Ning Desheng , Wu Xingde , Huang Sisi , Li Dianpeng , Lv Shihong 
Published: July 2015

Abstractisolation and structure elucidation of three new clerodane diterpenoids (I)‐(III)
ChemInform Abstract: α‐Glucosidase Inhibitory Monoacylated Polyhydroxytriterpenoids from the Fruits of Barringtonia racemosa.
Authors: Ponnapalli Mangala Gowri , Sukki Sushma , Annam S. CH. V. Appa Rao , Ankireddy Madhu , Tirunagari Harini , Tuniki V. Raju , Bobbili V. V. Pardhasaradhi 
Published: July 2015

AbstractMonoacylated polyhydroxy triterpenoids racemosol C (I) and racemosol D (II) encountered in this study are unusual and exhibit excellent α‐glucosidase inhibition and moderate cytotoxicity.
ChemInform Abstract: Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum that Displays Potent Antifibrotic Activity.
Authors: Luo Qi , Di Lei , Dai Wei‐Feng , Lu Qing , Yan Yong‐Ming , Yang Zhu‐Liang , Li Rong‐Tao , Cheng Yong‐Xian 
Published: July 2015

AbstractThe title compound inhibits fibrogenic action of TGF‐β1 in human renal proximal tubular cells and selectively blocks TGF‐β1‐mediated Smad2 and Smad3 phosphorylation in a dose‐dependent manner.
ChemInform Abstract: Strategies for Synthesizing Non‐bioaccumulable Alternatives to PFOA and PFOS
Authors: Sha Min , Xing Ping , Jiang Biao 
Published: July 2015

AbstractReview: presentation of various strategies for the synthesis of highly (per)fluorinated surfactants as novel alternatives to perfluorooctanoic acid (PFOA) and perfluorooctane sulphonate (PFOS); 64 refs.
ChemInform Abstract: Recent Advances in Dialkyl Carbonates Synthesis and Applications
Authors: Huang Shouying , Yan Bing , Wang Shengping , Ma Xinbin 
Published: July 2015

AbstractReview: recent advances in the synthesis and applications of dialkyl carbonates, with focus on the catalyst rational design, catalytic mechanism, and process intensification in the CO and CO2 routes; 433 refs.
ChemInform Abstract: Zinc Tetrafluoroborate: A Versatile and Robust Catalyst for Various Organic Reactions and Transformations
Authors: Sarkar Anirban , Santra Sougata , Kundu Shrishnu Kumar , Ghosal Nirnita Chakraborty , Hajra Alakananda , Majee Adinath 
Published: July 2015

AbstractReview: [27 refs.
ChemInform Abstract: The Chemistry and Bioactivity of Southern African Flora. Part 1. A Bioactivity versus Ethnobotanical Survey of Alkaloid and Terpenoid Classes
Authors: Babiaka Smith B. , Ntie‐Kang Fidele , Lifongo Lydia L. , Ndingkokhar Bakoh , Mbah James A. , Yong Joseph N. 
Published: July 2015

AbstractReview: [210 refs.
Cooling crystallization of aluminum sulfate in pure water modulated by sodium dodecylbenzenesulfonate
Authors: Sun Xiaoxue , Sun Yuzhu , Yu Jianguo 
Published: July 2015

This study investigated the cooling crystallization of aluminum sulfate to explore the basic data for the recovery of aluminum resources from coal spoil.Cooling crystallization process of aluminum sulfate with sodium dodecylbenzenesulfonate (SDBS) was investigated experimentally. The effects of operating conditions, namely rotate speed and cooling rate on the crystal size (Median diameter, D0.5) were studied. Based on single factor experimental results, the response surface method (RSM) with a Box–Behnken design (BBD) was used to determine the key operating conditions, from which a predictive equation was established to quantitatively describe the relationships of D0.5 and there relative parameters. The optimum operating conditions for cooling crystallization of aluminum sulfate were as follows: rotate speed of 200–300 rpm, cooling rate of 4–5 °C /min and n (SDBS)/n (Al2(SO4)3) of around 5E‐4.Molecular dynamics (MD) results reveal that SDBS decreases the diffusion coefficient (D) of Al3+ molecules, which inhibits nucleation and promotes crystal growth.
Thromboembolic risk stratification of patients hospitalized with heart failure in sinus rhythm: a nationwide cohort study
Authors: Wolsk Emil , Lamberts Morten , Hansen Morten L. , Blanche Paul , Køber Lars , Torp‐Pedersen Christian , Lip Gregory Y. H. , Gislason Gunnar 
Published: July 2015

AimsPatients with heart failure in sinus rhythm are at an increased risk of thromboembolic complications. So far, validated risk stratification tools are lacking for such patients, which makes the decision to initiate anti‐thrombotic treatment difficult.Methods and resultsWe included 136 545 patients admitted with heart failure in sinus rhythm from national registries from 1999 to 2012. Patients receiving oral anticoagulants were omitted from the study. First, we investigated if the CHA2DS2‐VASc score could identify heart failure patients in sinus rhythm with high rates of thromboembolic complications. Second, we investigated if any single CHA2DS2‐VASc risk factor carried a greater prognostic value with regard to thromboembolism. The risk of thromboembolism increased more than ninefold (hazard ratio 9.2, 95% confidence interval 6.8–12.5) in patients with all CHA2DS2‐VASc risk factors compared with those with heart failure alone. The incidence rates of thromboembolism were clinically significant, averaging 6.0 (95% confidence interval 5.98–6.02) events per 100 patient years during the first year following diagnosis. Risk factors such as diabetes, age, vascular disease, and especially previous thromboembolism, conferred an independent risk of future thromboembolism.ConclusionThe CHA2DS2‐VASc risk stratification scheme was able to provide prognostic information on future thromboembolic events in patients with heart failure in sinus rhythm. The CHA2DS2‐VASc scale could be easily implemented as an aid to clinicians in risk stratifying heart failure patients in sinus rhythm, for thromboembolism.