bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro Anti‐Adherent Assessment of Selected Lactic Acid Bacteria Isolates Against Salmonella Typhimurium and Listeria monocytogenes to Caco‐2 Cells
Authors: Sribuathong Supannikar , Saengprakai Janpen , Trevanich Sudsai 
Published: June 2014

AbstractThe present study aimed to evaluate in vitro anti‐adherence abilities of the probiotic potential of three selected lactic acid bacteria (LAB) strains isolated from fermented broken rice with two foodborne pathogenic bacteria to Caco‐2 cells. Lactobacillus plantarum Ban Pra Doke 110 was the most adherent strain with an adherence of 17.66% at a concentration of added bacterial cells of 2.0 × 108 cfu/mL (multiplicities of infection 100). In the exclusion, competition and displacement tests, Lact. plantarum PD 110 showed the most anti‐adherence abilities against Salmonella Typhimurium American Type Culture Collection 13311 and Listeria monocytogenes ScottA to Caco‐2 cells. Moreover, the presence of its spent culture supernatant exhibited the highest decrease in the percentage numbers of the adherent pathogenic bacteria used in all tests. The effectiveness of each LAB strain was tested to adhere to Caco‐2 cells or to prevent the adherence of the test pathogenic bacteria varied widely depending on the genus and species, source of origin, and assay condition, as well as adherent‐promoting factors.Practical ApplicationsFoodborne pathogen infection to the human intestinal epithelial surface cells is a critical step for the survival and cause foodborne illness. The anti‐adherent assessment of novel probiotic is of importance for the inhibition of pathogen infections. Lactobacillus plantarum PD 110 isolated from fermented broken rice could be one of these good candidates. The demonstrated in vitro anti‐adherent activity of Lact. plantarum PD 110 to Caco‐2 cells recommends its possible application as a probiotic candidates in order to inhibit the adherence of Salmonella Typhimurium and Listeria monocytogenes to the human gastrointestinal tract. Therefore, this strain can be considered as a novel potential starter culture to improve the quality and safety of functional foods.
Estimation of Shelf Life with Respect to Bacillus cereus Growth in Tteokgalbi at Various Temperatures Using Predictive Models
Authors: Heo Chan , Kim Hyun Wook , Ko Kyung Yuk , Kim Kee‐Tae , Paik Hyun‐Dong 
Published: June 2014

AbstractPredictive models to describe the growth of Bacillus cereus in tteokgalbi were developed during storage under various temperatures (5–25C) and inoculation levels (2 and 3 log) to estimate the shelf life. To develop primary models, the observed data were applied to the Baranyi and Gompertz equations. The growth rate was dependent on temperature, but the effect of inoculation level on growth rate was not significant (P > 0.05). Thus, the secondary polynomial model was developed as a function of temperature. At 5C, the predicted shelf life of tteokgalbi was approximately 65.5–73.2 h. The shelf life at 15 or 25C decreased sharply during storage, and was less than 20 h during storage. All primary and polynomial secondary models were characterized by high R2 values, small root mean square error values and very ideal values of Bf and Af. These results present reliable predictive growth models describing the growth of B. cereus under various temperature conditions in tteokgalbi.Practical ApplicationsMany traditional homemade foods have been industrialized at recent days. Tteokgalbi is the most popular processed pork product in Korea, and the acceptability of consumers is high because of its good flavor and nutritional value. During industrial production, the possibility of contamination of pathogens including Bacillus cereus can be high through manufacture and distribution. The predictive model in this study can be used to control the possibility of contamination for safety of tteokgalbi as basic information.
In situ expression and serum level of thymic stromal lymphopoietin in oral lichen planus
Authors: Sun Mingxia , Tan Wanye , Liu Shaohua , Liu Guixiang , Zhang Xiaoying , Wang Ning , Qu Xun , Wei Fengcai 
Published: June 2014

BackgroundOral lichen planus (OLP) is a chronic inflammatory disease of oral mucosa in which the CD8+ T cell‐mediated cytotoxicity is regarded as a major mechanism of pathogenesis. The main objective of this study is to investigate in situ expression and secretion of thymic stromal lymphopoietin (TSLP) in specimens and sera from patients with oral lichen planus.MethodsThirty‐six patients with OLP and 35 donors enrolled in specimen and serum collection. Immunohistochemical method and immunofluorescence double‐staining method were used to detect the expression of thymic stromal lymphopoietin and its receptor (TSLPR) together with CD8 in OLP specimens. Enzyme‐linked immunosorbent assay (ELISA) was used to detect TSLP secretion.ResultsMore TSLP‐ or TSLPR‐positive cells showed in OLP specimens than in normal controls, and TSLP‐positive cells were mainly in the epithelium, while TSLPR‐positive cells mainly in the lamina propria. Furthermore, the number of TSLP‐positive cells in the stratum basal was associated with the amount of mononuclear cells infiltrating in the lamina propria of OLP specimens. Among infiltrating mononuclear cells in the lamina propria, some CD8‐positive cells also expressed TSLPR. The TSLP serum level of patients with OLP was significantly higher than of healthy donors, but there was no statistically difference between two clinical subtypes of OLP.ConclusionsOur findings provided the first evidence that TSLP may enroll in the pathology of OLP and the TSLP–TSLPR interaction may play an important role in it.
NTPDase Specific Inhibitors Suppress Rice Infection by Magnaporthe oryzae
Authors: Long Bin , Li Gui‐Hua , Feng Rong‐Rong , Tao Lan , Liu Dian‐Dian , Feng Hui‐Qiang , Qin Qing‐Ming 
Published: June 2014

AbstractEvolutionarily conserved ecto‐nucleoside triphosphate diphosphohydrolases (referred to ‘NTPDases’ below) are important ecto‐nucleotidases that are able to hydrolyse NTPs and NDPs in the environment to the monophosphate form. NTPDases are found in a variety of eukaryotic organisms including medical pathogens. However, pathogenic roles of these NTPDases in medical and plant pathogens are still very obscure. Here, we demonstrate that conidial germination, appressorium formation and pathogenicity of rice blast fungus Magnaporthe oryzae that had been pretreated with NTPDase‐specific inhibitors were significantly reduced, suggesting that NTPDases of M. oryzae play an important role in its infection. Our findings may provide a new avenue for powerful fungicide development and the control of rice blast.
Safety and toxicity of radioembolization plus Sorafenib in advanced hepatocellular carcinoma: analysis of the European multicentre trial SORAMIC
Authors: Ricke Jens , Bulla Karsten , Kolligs Frank , Peck‐Radosavljevic Markus , Reimer Peter , Sangro Bruno , Schott Eckart , Schütte Kerstin , Verslype Chris , Walecki Jerzy , Malfertheiner Peter ,   the SORAMIC study group
Published: June 2014

AbstractBackground & AimsThe benefits of combined systemic and liver‐directed treatments in inoperable intermediate‐ or advanced‐stage hepatocellular carcinoma (HCC) have yet to be defined. This article presents the planned safety analyses for the first 40 patients randomized to radioembolization with yttrium‐90 (90Y) resin microspheres followed by sorafenib (n = 20) or sorafenib only (n = 20) in the SORAMIC study.MethodsPatients identified for palliative treatment who were poor candidates for transarterial (chemo)embolization (including those failing TACE) with preserved liver function (Child–Pugh ≤B7) and ECOG performance status <2 were screened. Radioembolization was administered using a sequential lobar approach. On day 3 after the last radioembolization procedure, sorafenib 200 mg twice daily was initiated escalating to 400 mg twice daily 1 week later; a matching sorafenib dose schedule was initiated in the control arm.ResultsPatients were followed up for a median of 8.3 months. Median total implanted activity of 90Y was 1.87 (range: 0.54–2.35) GBq. Patients received a similar intensity and duration of sorafenib in the combination‐treatment arm (median daily dose 614 mg over 8.5 months) and control arm (557 mg over 9.6 months). The incidence of total (196 vs. 222) and grade ≥3 (43 vs. 47) adverse events was similar in combination‐treatment arm and control arm respectively (P > 0.05). No significant differences in the number of total or grade 3/4 toxicities were recorded for: total bilirubin, albumin, liver enzymes, ascites, Child–Pugh, fatigue, hand–foot skin reaction, blood pressure or diarrhoea.ConclusionsRadioembolization followed by sorafenib appears to be as well tolerated as sorafenib alone.
Impacts of wind waves on sediment transport in a large, shallow lake
Authors: Ji Zhen‐Gang , Jin Kang‐Ren 
Published: June 2014

AbstractLake Okeechobee is a large, shallow subtropical lake, located in south Florida. Over the last several decades, Lake Okeechobee has experienced accelerated eutrophication due to excessive phosphorus loads from agricultural run‐off. Recycling of phosphorus from bottom sediments through resuspension is critical to addressing eutrophication of the lake and for water quality management. The present study investigates the impacts of wind waves on sediment transport in Lake Okeechobee, using measured data and the Lake Okeechobee Environmental Model (LOEM). The LOEM was fully calibrated and verified with more than 10 years of measured data in previous studies. Analysis of the measured data indicates significant wave height (SWH) and suspended sediment concentration are closely correlated to the wind speed in the lake. The nonlinear interaction of high‐frequency wind waves with relatively low‐frequency currents in the boundary layer plays a key role in sediment deposition/resuspension. Without considering the effects of wind waves, the bottom shear stress can be greatly underestimated. The spatial variations of key variables for sediment modelling, including SWH, water depth, orbital velocity, current velocity, bottom shear stress and sediment concentration, are discussed. In general, the near‐bottom wave velocity (and the associated bottom shear stress) is greater than or the same order of magnitude as the near‐bed current velocity (and the associated bottom shear stress) in this shallow water system. Although the sediment zones of Lake Okeechobee were described in previous studies, few published papers discussed its formation mechanisms. The findings of the present study include that the multiyear averaged bottom shear stress with wind‐wave effect plays a key role in forming the spatial patterns of the sediment zones. The study results are currently being used in lake management and in developing strategies for reducing phosphorus in the lake.
Lakes of Malaysia: Water quality, eutrophication and management
Authors: Sharip Zati , Zaki Ahmad T. A. , Shapai Mohd. A. H. M. , Suratman Saim , Shaaban Ahmad J. 
Published: June 2014

AbstractThe present study was undertaken to evaluate and verify the water quality status and trophic state of 15 major lakes and reservoirs in Malaysia. The lake water quality assessments were based on the National Water Quality Index (NWQI), while the trophic state assessments were based on Carlson's Trophic State Index (TSI). The findings of this water quality assessment, based on data collected between September and October 2012, indicated that a majority of the lakes were classified as Class II (Clean) waters suitable for recreational use. The results of the trophic state assessments, however, indicated that all of the lakes were eutrophic, meaning they were nutrient‐rich, they could experience algae blooms or macrophyte problems, and they were likely to exhibit poor water quality. Sustainable management measures and strategies are suggested to address the eutrophication problems of Malaysian lakes and reservoirs, with the national responses on lake and reservoir management also being discussed.
Ambiguous immigrants? Examining the changing status of the English in New Zealand
Authors: Pearson David 
Published: June 2014

AbstractDrawing on a qualitative interview‐based study of English migrants in New Zealand, this article examines, if and how, overseas migration triggers national sentiments that were previously relatively amorphous in their country of origin. In those cases where this occurs, it analyses the diverse and contextual orientations migrants display, and discusses the empirical and analytic challenges posed when seeking to conceptualise a category of persons that have been described as ‘ambiguous immigrants’. The study concludes that research on this ambiguity contributes to debates about the relationship between dominant ethnicity and national identity while highlighting the simplicities of many concepts used to describe and analyse ‘the English’.
Articulating national identity in Turkmenistan: inventing tradition through myth, cult and language
Authors: Clement Victoria 
Published: June 2014

AbstractA study of myth, cult, and language as tools of state power, this paper analyzes ways national identity was constructed and articulated in one state. When Türkmenistan became independent in 1991 its first president, Saparmyrat Nyýazow, promoted himself as the ‘savior’ of the nation by reconceptualising what it meant to be Türkmen. Myth, public texts and language policy were used to construct this identity. While they were the targets of the state's cultural products, Türkmen citizens contributed to the processes of cultural production. Nyýazow legitimised his authoritarian leadership, first by co‐opting Türkmen citizens to support his regime, and then by coercing them as participants in his personality cult. The paper concludes that Nyýazow used the production of culture, ‘invented tradition’ in Hobsbawm's sense, to bolster his agenda and further his own power. It also argues that the exaggerated cult of personality Nyýazow cultivated limited his achievements, rather than solidifying them.
Exploring the roots and dynamics of Kurdish ethno‐nationalism in Turkey
Authors: Sarigil Zeki , Fazlioglu Omer 
Published: June 2014

AbstractUsing comprehensive and original data derived from a recent major public opinion survey, this study examines an under‐investigated aspect of the Kurdish issue in Turkey: the dynamics and factors behind Kurdish ethno‐nationalism at a mass level. The empirical findings disprove the conventional socio‐economic peace and Islamic‐peace hypotheses around this issue, and our statistical analyses provide strong support for the relative deprivation hypothesis, i.e. that those who think the Turkish state discriminates against Kurds are more likely to have ethno‐nationalist orientations. Multivariate analyses further show that religious sectarian differences among Kurds (i.e. the Hanefi‐Shafi division) matter: the more religious Shafi Kurds have a stronger ethnic consciousness and a higher degree of ethno‐nationalism. The study also provides a discussion of the broader theoretical and practical implications of the empirical findings, which may provide insights into conflict resolution prospects in countries with a Kurdish population.
Freemasonry as a playground for civic nationalism
Authors: Kaplan Danny 
Published: June 2014

AbstractThis article explores correspondences between the ideals of ‘civic nationalism’ (hereafter CN) and the practices of Freemasonry, a worldwide male fraternity. Freemasons practice an elitist stance of civilizing the self, translated into a collective mission of society‐building. Though not a national movement, Freemasonry shares conceptual similarities with CN and was implicated in civic‐national revolutions in the Americas and the Middle East. Drawing on ethnographic research on Israeli Freemasonry, the study explores Masonic sociability as a playgound for practicing civic friendship and negotiating the inherent tensions of CN. Freemasons straddle between particularist and universalist understandings of fraternity, virtue and charity, which carry over to questions of citizenship, patriotism and nationalism. This boundary work over collective attachments represents a pragmatic attempt, not to resolve universalist and particularist preferences, but to contain and incorporate both within exclusivist Masonic practices. Far from marking the failure of CN, Masonic sociability illustrates its political significance, envisioning the nation as a social club of chosen friends.
Nodular Cystic Fat Necrosis with Calcification in a Patient with Juvenile Dermatomyositis
Authors: Ferenczi Katalin , Berke Adrienne , Makkar Hanspaul S. 
Published: June 2014

AbstractNodular cystic fat necrosis is a rare, benign form of encapsulated fat necrosis with distinct histology, characterized by cystic fat necrosis with lipomembranous changes and, in later stages, calcification. We report the case of a 7‐year‐old child with juvenile dermatomyositis who presented with three asymptomatic, firm, mobile nodules on the arms and neck. Histology was consistent with nodular cystic fat necrosis with prominent calcification. This is an unusual presentation of this entity because it has never been previously reported in association with juvenile dermatomyositis.
Prophylactic eculizumab for kidney transplantation in a child with atypical hemolytic uremic syndrome due to complement factor H mutation
Authors: Ranch Daniel , Crowther Barrett , Arar Mazen , Assanasen Chatchawin 
Published: June 2014

AbstractWe present a case of successful deceased‐donor kidney transplantation in a three‐yr‐old child with aHUS due to complement factor H mutation, using only prophylactic eculizumab treatment prior to transplant. She developed disease exacerbation in the immediate post‐operative period despite having therapeutic eculizumab concentrations and evidence for complete complement pathway blockade. The patient responded well to additional doses of eculizumab and has maintained excellent graft function and disease control in the first year post‐transplantation. The optimal dosing scheme for eculizumab in the perioperative period remains to be determined. More sensitive biomarkers of early disease activity are needed to improve disease monitoring. Finally, the duration of eculizumab therapy in patients with aHUS remains to be determined.
Long‐term outcome of pediatric renal transplantation: A single center study in Japan
Authors: Yamada Akio , Tashiro Atsushi , Hiraiwa Tomoko , Komatsu Tomonori , Kinukawa Tsuneo , Ueda Norishi 
Published: June 2014

AbstractLittle is known about the risk factors for long‐term poor outcome in pediatric renal transplantation. Between 1973 and 2010, 111 renal transplants (92 living donations) were performed in 104 children (56 males, mean age, 12.5 yr) at the Social Insurance Chukyo Hospital, and followed‐up for a mean period of 13.6 yr. The patient survival at 1, 5, 10, 15, 20 (living‐ and deceased‐donor transplants), and 30 yr (living‐donor transplants only) was 98.1%, 92.8%, 87.8%, 84.9%, 82.6%, and 79.3%. The graft survival at 1, 5, 10, 15, 20, and 30 yr was 92.0%, 77.3%, 58.4%, 50.8%, 38.5%, and 33.3%. The most common cause of graft loss was CAI, AR, death with functioning, recurrent primary disease, ATN, and malignancy. Donor gender, ATN, malignancy/cardiovascular events, and eras affected patient survival. AR and CAI were the risk factors for graft loss. The evolved immunosuppression protocols improved the outcome by reducing AR episodes and ATN but not CAI, suggesting CAI as the major risk factor for graft loss. CAI was correlated with AR episodes, CMV infection, and post‐transplant hypertension. Strategies for preventing the risk factors for malignancy/cardiovascular events and CAI, including hypertension/infection, are crucial for better outcomes.
Dem quality assessment with a 3d printed gravel bed applied to stereo photogrammetry
Authors: Bertin S. , Friedrich H. , Delmas P. , Chan E. , Gimel'farb G. 
Published: June 2014

AbstractUsing stereo photogrammetry to obtain digital elevation models (DEMs) for surface topography analysis is becoming popular in hydraulic research, especially for coarse gravel beds. This paper assesses the DEM quality by using a realistic 3D printed gravel‐bed model, with known elevations every 0·25 mm, as ground truth. Two Nikon D5100 cameras and non‐proprietary photogrammetric software for camera calibration and DEM reconstruction are used for the study. A measured DEM is compared point by point with the ground truth and displays a very high measurement accuracy. The 3D printing of ground truths facilitates fast and versatile evaluation of both the DEM quality and the sensitivity of its errors to changes in surface topography and collection parameters. It has the potential to streamline evaluations of calibration and image quality, as well as error filtering strategies. Ultimately, 3D printed models will help in exploring stereomatching error reductions in occluded regions and defining the most suitable strategy for gravel‐bed DEM collection, both in air and through water.
The Effects of Isoflavones on Androgens and Glucocorticoids During Puberty on Male Wistar Rats
Authors: Caceres S , Silvan G , Martinez‐Fernandez L , Illera MJ , Millan P , Monsalve B , Peña L , Illera JC 
Published: June 2014

ContentsIsoflavones are the most common phytoestrogens found in human diets. However, it is still not clear whether isoflavones have effects on the reproductive and the endocrine systems under normal dietary intake and overdose. The aim of this study was to determine how the most important isoflavones, genistein and daidzein, affect androgen and glucorticoid levels on male prepuberal rats. A hundred and seventy‐five 30‐day‐old male Wistar rats were dosed orally by stomach tube every day for 35 days, with saline solution, low and high doses of genistein, daidzein and a mixture of both. Serum samples were analysed by an enzyme immunoassay for hormone determinations. In control group, there was a peak of testosterone (T) and dihydrotestosterone levels associated to the onset of puberty, at the third week. However, in low‐dose groups, the same peak was found at the fourth week (p < 0.05), indicating a delay in the onset of puberty in these groups. Moreover, high doses groups serum androgen levels were significantly lower (p < 0.05) than the control group from the first week until fifth week. This fact was supported by a epididymal histological analysis that indicate in low doses there were several content of spermatozoa at fourth week and in high doses there were few content of spermatozoa. Besides, corticosterone levels followed the same pattern of androgens in all groups. We can conclude that oral administration of isoflavones in male rats decreased the secretion of androgens and glucocorticoids causing a delay in the onset of puberty and may cause physiological and developmental problems.