bluuebunny/crossref_metadata_2025_split huggingface dataset:
FHS-adapter: fine-grained hierarchical semantic adapter for Chinese landscape paintings generation
Authors: Peng Xianlin , Hu Qiyao , Fan Fangqing , Xie Penglin , Zhang Yihan , Cao Rui 
Published: July 2024

Abstract
How to migrate text-to-image models based on pre-trained diffusion models to adapt them to domain generation tasks is a common problem. In particular, the generation task for Chinese landscape paintings with unique characteristics suffers from a scarcity of fine-grained contextual details specific to such artwork. Moreover, the use of substantial amounts of non-landscape painting data during pre-training predisposes the model to be swayed by alternative visual styles, thereby leading to generated images that inadvertently lack the distinctive traits inherent to Chinese paintings. In this paper, we propose a Fine-grained Hierarchical Semantic Adapter for Chinese landscape paintings generation, namely FHS-adapter. The method orchestrates the diffusion process in a batch-wise manner, leveraging external fine-grained multi-perspective information to guide it. It gradually diminishes the influence of other style images embedded in the pre-trained diffusion model, ultimately preserving a greater number of landscape painting elements. The encoder was also replaced with the Taiyi-CLIP encoder, which is adapted for Chinese. We propose T2ICLP, a multimodal dataset containing 10,000 high-quality image-text pairs of Chinese landscape paintings. Unlike previous datasets, this dataset extracts fine-grained textual information from four perspectives, including Meta, Description, Sentiment, Poem. We compared the proposed model with the mainstream diffusion-based T2I models. Through an anonymous user study, our FHS-adapter method performs well in simulating various aspects such as brushwork, e.g.‘Gou, Cun, Dian, Ran’ means hooking, texturing, dotting, and dyeing, compositional space, elemental proportions, and color usage of different painting genres and artists. Our dataset is available at https://github.com/T2ICLP/t2iclp.
Recombinant GH3 β-glucosidase stimulated by xylose and tolerant to furfural and 5-hydroxymethylfurfural obtained from Aspergillus nidulans
Authors: de Andrades Diandra , Alnoch Robson C. , Alves Gabriela S. , Salgado Jose C. S. , Almeida Paula Z. , Berto Gabriela Leila , Segato Fernando , Ward Richard J. , Buckeridge Marcos S. , Polizeli Maria de Lourdes T. M. 
Published: July 2024

AbstractThe β-glucosidase gene from Aspergillus nidulans FGSC A4 was cloned and overexpressed in the A. nidulans A773. The resulting purified β-glucosidase, named AnGH3, is a monomeric enzyme with a molecular weight of approximately 80 kDa, as confirmed by SDS-PAGE. Circular dichroism further validated its unique canonical barrel fold (β/α), a feature also observed in the 3D homology model of AnGH3. The most striking aspect of this recombinant enzyme is its robustness, as it retained 100% activity after 24 h of incubation at 45 and 50 ºC and pH 6.0. Even at 55 °C, it maintained 72% of its enzymatic activity after 6 h of incubation at the same pH. The kinetic parameters Vmax, KM, and Kcat/KM for ρ-nitrophenyl-β-D-glucopyranoside (ρNPG) and cellobiose were also determined. Using ρNPG, the enzyme demonstrated a Vmax of 212 U mg − 1, KM of 0.0607 mmol L − 1, and Kcat/KM of 4521 mmol L − 1 s − 1 when incubated at pH 6.0 and 65 °C. The KM, Vmax, and Kcat/KM using cellobiose were 2.7 mmol L − 1, 57 U mg − 1, and 27 mmol –1 s − 1, respectively. AnGH3 activity was significantly enhanced by xylose and ethanol at concentrations up to 1.5 mol L − 1 and 25%, respectively. Even in challenging conditions, at 65 °C and pH 6.0, the enzyme maintained its activity, retaining 100% and 70% of its initial activity in the presence of 200 mmol L − 1 furfural and 5-hydroxymethylfurfural (HMF), respectively. The potential of this enzyme was further demonstrated by its application in the saccharification of the forage grass Panicum maximum, where it led to a 48% increase in glucose release after 24 h. These unique characteristics, including high catalytic performance, good thermal stability in hydrolysis temperature, and tolerance to elevated concentrations of ethanol, D-xylose, furfural, and HMF, position this recombinant enzyme as a promising tool in the hydrolysis of lignocellulosic biomass as part of an efficient multi-enzyme cocktail, thereby opening new avenues in the field of biotechnology and enzymology.
Concentration modulated microstructure and rheological properties of nanofibrous hydrogels derived from decellularized human amniotic membrane for 3D cell culture
Authors: Kafili Golara , Tamjid Elnaz , Niknejad Hassan , Simchi Abdolreza 
Published: July 2024

AbstractDecellularized amnion (dAM)-derived hydrogels have been extensively exploited for versatile medical and therapeutical applications, particularly for soft tissue engineering of skin, vascular graft, and endometrium. In contrast to polyacrylamide-based hydrogels, which have been extensively employed as a 3D cell culture platform, the cell response of dAM hydrogel is yet to be understood. In this study, we have prepared hydrogels containing different concentrations of dAM and systematically investigated their microstructural features, gelation kinetics, and rheological properties. The results show that dAM hydrogels possess a network of fibers with an average diameter of 56 ± 5 nm at 1% dAM, which increases to 110 ± 14 nm at 3% dAM. The enhanced intermolecular crosslinking between the microfibrillar units increases the gelation rate in the growth phase of the self-assembly process. Moreover, increasing the concentration of dAM in the hydrogel formulation (from 1 to 3%w/v) enhances the dynamic mechanical moduli of the derived hydrogels by about two orders of magnitude (from 41.8 ± 2.5 to 896.2 ± 72.3 Pa). It is shown that the variation in the hydrogel stiffness significantly affects the morphology of dermal fibroblast cells cultured in the hydrogels. It is shown that the hydrogels containing up to 2%w/v dAM provide a suitable microenvironment for embedded fibroblast cells with spindle-like morphology. Nevertheless, at the higher concentration, an adverse effect on the proliferation and morphology of fibroblast cells is noticed due to stiffness-induced phenotype transformation of cells. Concentration-modulated properties of dAM hydrogels offer an in vitro platform to study cell-related responses, disease modeling, and drug studies.
Graphical abstract
Feasibility and acceptability of an online multicomponent very low-carbohydrate intervention in young adult women with obesity: a pilot study
Authors: Saslow Laura R. , O’Brien Alison , Raymond Kaitlyn , Bayandorian Hovig , Marriott Deanna , Moskowitz Judith T. , Daubenmier Jennifer , Bridges Dave , Cousineau Cody M. , Griauzde Dina H. 
Published: July 2024

Abstract
Background
Approximately one-third of US young adults (18–25 years) have obesity, and there are calls to help young adults lose weight to prevent weight-related chronic conditions. This pilot trial tested the feasibility and acceptability of a very low-carbohydrate (VLC) eating pattern, with supportive positive affect and mindful eating skills, for weight management among young females with obesity.

Methods
In a single-arm trial, women (N = 17), aged 19–23, with obesity participated in a 4-month diet and lifestyle intervention. Participants were taught how to follow a VLC eating pattern with the help of a coach and 16 weekly web-based sessions. We assessed feasibility and acceptability through session participation, outcome collection, intervention satisfaction, and adverse events.

Results
Seventeen participants enrolled and 14 (82%) reported body weight at 4 months. Fifteen participants (94% of those beginning the intervention) viewed at least one session, and 8/15 (53%) of these participants were active in the intervention, viewing at least half of the sessions. Among the nine participants who provided 4-month self-report information, intervention satisfaction was high (mean 5.89/7, 95% CI 4.59 to 7.19). Among participants with a 4-month body weight, 7/14 (50%) lost ≥ 5% of their body weight, and of those who were also active in the intervention, 6/7 (86%) lost ≥ 5% of their body weight. There were no serious adverse events.

Conclusions
The results of this pilot study suggest that a VLC eating pattern may be a feasible and acceptable approach for weight loss in some young women with obesity.

Trial registration
This trial was registered with ClinicalTrials.gov on August 18, 2021. The trial number is NCT05010083.
Google search volume index and investor attention in stock market: a systematic review
Authors: Ayala María José , Gonzálvez-Gallego Nicolás , Arteaga-Sánchez Rocío 
Published: July 2024

AbstractThis study systematically reviewed the literature on using the Google Search Volume Index (GSVI) as a proxy variable for investor attention and stock market movements. We analyzed 56 academic studies published between 2010 and 2021 using the Web of Sciences and ScienceDirect databases. The articles were classified and synthesized based on the selection criteria for building the GSVI: keywords of the search term, market region, and frequency of the data sample. Next, we analyze the effect of returns, volatility, and trading volume on the financial variables. The main results can be summarized as follows. (1) The GSVI is positively related to volatility and trading volume regardless of the keyword, market region, or frequency used for the sample. Hence, increasing investor attention toward a specific financial term will increase volatility and trading volume. (2) The GSVI can improve forecasting models for stock market movements. To conclude, this study consolidates, for the first time, the research literature on GSVI, which is highly valuable for academic practitioners in the area.
Co-creating and hosting PxP: a conference about patient engagement in research for and by patient partners
Authors: Richards Dawn P. , Mulhall Hetty , Belton Joletta , de Souza Savia , Flynn Trudy , Haagaard Alex , Hunter Linda , Price Amy , Riggare Sara , Tufte Janice , Twomey Rosie , Khan Karim M. 
Published: July 2024

Abstract
Research projects, initiatives and conferences that include patients as partners rather than as participants are becoming more common. Including patients as partners (what we will call ‘patient partners’) is an approach called patient engagement or involvement in research, and we will call it patient engagement throughout this paper. Patient engagement moves traditional health research conferences and events to include a broader audience for their knowledge exchange and community building efforts, beyond academics and healthcare professionals. However, there are few examples of conferences where patients are given the opportunity to fully lead. Our conference went beyond patient engagement – it was patient-led. Patient partners conceived, planned, and decided on all aspects of a virtual conference.
We present the work and processes we undertook throughout 2023 to create and produce a free conference called “PxP: For patients, by patients” or PxP for short, with a tagline of “Partnering to make research stronger.” PxP was patient-led and about patient engagement in research rather than a specific disease or condition. PxP was supported by the Canadian Institutes of Health Research Institute of Musculoskeletal Health and Arthritis. The PxP website, known as the PxP Hub, now houses the conference recordings along with resources about patient engagement in research. These resources were recommended by the PxP Steering Committee members, speakers, and others who attended the 2023 conference. Here we lead you through how the idea for PxP was generated; how the international patient partner Steering Committee was convened and supported; how PxP was brought to life over nine months; the PxP 3-day event and feedback collected to improve future efforts; trade-offs, challenges and learnings; and resources required to support this type of event. We close with what the future holds for PxP in 2024 and beyond.
It’s time to elevate patients into leadership roles for conferences and events, and we encourage you to adopt the PxP ethos by using or adapting our approach and resources to support your opportunity.
Long-term functional, anatomical outcome, and qualitative analysis by OCTA, as a predictor of disease recurrences in patients with choroidal neovascularization secondary to angioid streaks
Authors: Velez-Montoya Raul , Osorio-Landa Hillary K. , Franco-Ramirez K. Carolina , Martínez-Pacheco Victor , Ramirez-Estudillo J. Abel , Rosales-Padrón Jaime Francisco , Ledesma-Gil Gerardo , Fromow-Guerra Jans 
Published: July 2024

Abstract
Background
To report the risk of exudation recurrence and long-term outcomes in patients with choroidal neovascularization secondary to angioid streaks, according to its morphology and characteristics by optical coherence tomography angiography.

Methods
Retrospective analysis of electronic medical records from three hospitals. We enrolled patients with a clinical diagnosis of angioid streaks choroidal neovascularization that had a minimum follow-up of 12 months. From each record, we extracted general demographic data, best corrected visual acuity (baseline, before and after each disease recurrence and last on file), type of treatment, time between last intravitreal injection and disease recurrence, and classification of the neovascular lesion morphology by optical coherence tomography, and optical coherence tomography angiography. Patients with myopic choroidal neovascularization were used as controls. Interobserver agreement was assessed with a Cohen-Kappa test. The Odds ratio was calculated with a chi2 test for significance. Visual acuity change through time was evaluated with an ANOVA for repeated measurements with an alpha value of 0.05 for statistical significance.

Results
We enrolled 30 patients in the study group and 14 in the control group. In the study group, the baseline and final BCVA were 0.861 ± 0.59 and 1.095 ± 0.61 logMAR (p = 0.1) respectively. Control group: 1.045 ± 0.57 and 0.617 ± 0.53 logMAR (p < 0.05). In the study group, the predominant CNV type by OCTA was mixed (37%), and interlacing (57%) in the control group. Mixed and cog-wheel patterns at baseline had increased Odds for recurrence in the study group (p = 0.09). Patients in the study group required more intravitreal injections on each recurrence episode to achieve disease control (3.5 ± 1.5 vs.1.4 ± 0.2, p < 0.01).

Conclusions
The benefits of anti-VEGF treatment are lost over time in patients with angioid streaks and CNV. Lesion characteristics by optical coherence tomography angiography could help physicians predict the risk of recurrence.

Trial registration
Retrospective registered, and IRB approved.
Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar
Authors: Scarso Salvatore , Rakotoarivelo Rivo Andry , Hey Jana Christina , Rasamoelina Tahinamandranto , Razafindrakoto Anjarasoa Ravo , Rasolojaona Zaraniaina Tahiry , Razafindralava Nantenaina Mathieu , Remkes Aaron , Rakotozandrindrainy Njary , Rasoamanamihaja Clara Fabienne , Schwarz Norbert Georg , May Jürgen , Rakotozandrindrainy Raphael , Marchese Valentina , Formenti Fabio , Perandin Francesca , Tamarozzi Francesca , Mazzi Cristina , Fusco Daniela , Buonfrate Dora 
Published: July 2024

Abstract
Background
Estimation of prevalence of Strongyloides stercoralis infection is required in endemic areas, in order to identify areas in need of control programmes. Data on prevalence of strongyloidiasis in Madagascar are scant. Aim of this work was to estimate prevalence of S. stercoralis in four districts of Madagascar.

Methods
Fecal and serum samples collected in the context of a previous study on schistosomiasis were tested with S. stercoralis real-time PCR and serology, respectively. A multiplex real-time PCR for Ascaris lumbricoides, Ancylostoma duodenalis, Necator americanus, and Trichuris trichiura was done on fecal samples collected in the areas demonstrating higher prevalence of strongyloidiasis. Comparisons between proportions were made using Fisher exact test, with false discovery rate correction used for post-hoc comparisons. A multivariable Firth logistic regression model was used to assess potential risk factors for S. stercoralis infection.

Results
Overall, 1775 serum samples were tested, of which 102 of 487 (20.9%) and 104 of 296 (35.2%) were serological-positive in Marovoay and in Vatomandry districts (both coastal areas), respectively, compared to 28 of 496 (5.6%) and 30 of 496 (6.1%) in Tsiroanomandidy and in Ambositra districts (both highlands), respectively (adj. p < 0.001). PCR for S. stercoralis was positive in 15 of 210 (7.1%) and in 11 of 296 (3.7%) samples from Marovoay from Vatomandry, respectively, while was negative for all samples tested in the other two districts. High prevalence of A. lumbricoides (45.9%), hookworm (44.6%) and T. trichiura (32.1%) was found in Vatomandry. In the multivariable analysis, strongyloidiasis was associated with hookworm infection. Hookworm infection was also associated with male sex and lower education level.

Conclusions
S. stercoralis prevalence proved higher in coastal areas compared to highlands. Different climatic conditions may explain this distribution, along with previous rounds of anthelminthics distributed in the country, which may have reduced the parasite load in the population. The high prevalence of the other soil-transmitted helminths (STH) in Vatomandry was unexpected, given the good coverage with benzimidazole in control campaigns. Further studies are needed to explore the risk factors for STH and S. stercoralis infections in Madagascar, in order to align with the WHO recommendations.
Ketamine in fibromyalgia: a systematic review
Authors: de Carvalho Jozélio Freire , de Sena Eduardo Pondé 
Published: July 2024

Abstract
Objective
Fibromyalgia (FM) subjects are treated with antidepressant agents; in most cases, these drugs lose efficacy or have adverse effects. Ketamine is an anesthetic drug used in FM in some studies. This article aims to systematically review the safety and efficacy of ketamine in fibromyalgia (FM) patients.

Materials and methods
We systematically searched articles on FM and ketamine published at Pubmed from 1966 to 2021. This study was registered at PROSPERO.

Results
There were only 6 articles published in this field, with a total of 115 patients. The female sex was predominant (88 to 100%). The age varied from 23 to 53 years old. Disease duration ranged from 1 month to 28 years. The dosage of ketamine changed from 0.1 mg/kg-0.3-0.5 mg/kg in intravenous infusion (4/5) and subcutaneous application (1/5). Regarding outcomes, the Visual analog scale (VAS) before ketamine was from 59 to 100 mm and after treatment from 2 to 95 mm. Most short-term studies had a good response. Only the study with 8 weeks of follow-up did not observe a good response. Side effects were common; all appeared during the infusion and disappeared after a few minutes of the ketamine injection.

Conclusions
The present study demonstrates the effectiveness and safety of ketamine in FM patients in the short term. Although, more studies, including long-term follow-up studies, are still needed.
Rapid early afterslip characteristics of the 2010 moment magnitude (Mw) 8.8 Maule earthquake determined with sub-daily GPS solutions
Authors: Liu Kai , Wen Yangmao , Zeng Jing , Geng Jianghui , Li Zhao , Xu Caijun 
Published: July 2024

AbstractGround surface deformations can be observed during the coseismic and postseismic periods. The accurate determination of displacements is of paramount importance for the assessment of the destructive power of large earthquakes and the characterization of fault behaviors. Therefore, we employ the sub-daily Global Positioning System (GPS) solutions at 19 GPS stations to determine the coseismic and postseismic deformations of the 2010 moment magnitude (Mw) 8.8 Maule earthquake. Using sub-daily GPS data, we can accurately measure both coseismic and early postseismic deformation signals, which can precisely identify the distribution of coseismic slip and the spatiotemporal evolution of early afterslip within the first 36 h. In particular, the sub-daily solution can provide more accurate and quicker results, nearly 10% smaller than those with the daily solution. Furthermore, there is significant ground motion in the immediate postseismic period, which decreases rapidly thereafter. The largest postseismic deformation observed during the first 2 h occurred at station CONZ and amounted to 3.6 cm. During the immediate postseismic period of the 2010 Maule earthquake, afterslip is the dominant mechanism, while poroelasticity plays a negligible role within the first 36 h. Meanwhile, early aftershocks tend to occur in the boundary and the inner part of the afterslip, indicating that the afterslip has the potential to drive the occurrence of aftershocks in the initial stages of postseismic activity.
Syntactic analysis of traditional houses in urban kampung
Authors: Asriana Nova , Khidmat Rendy Perdana , Jaya Meldo Andi , Ujung Verarisa Anastasia , Satria Widi Dwi , Andriani Riza 
Published: July 2024

AbstractThis research investigates a syntactical study and comparative analysis of the statistical and spatial characteristics of traditional houses in an urban kampung settlement, focusing on a selected case study built by a participatory Arabic community in Palembang, South Sumatra, Indonesia. This research aims to determine a formal rule basis for spatial configurations to reveal identical sociospatial structures based on syntactical analysis. This experiment measures spatial layout variation through space syntax analysis to provide a better understand of how the correlation between spatial configuration and sociospatial structures in traditional houses can be deconstructed. This syntactical analysis applies four distinctive procedures: a selected case study, data collection, statistical and graphical analysis, and graph analysis. The results indicate that the spatiality of all traditional houses in this kampung settlement highlights the spatial hierarchy order as a formal rule-based system, and approximately an average of 10% of this community is concerned with designing intelligible layouts. Rumah Batu and other dwellings have a similarity and closeness. The main dwelling’s function involves more steps to separate public and private functional rooms, but a functional transformation from a dwelling into a public facility creates a short distance for easy access by users. Additionally, this separation affects occupants, especially in terms of spatial distribution activities, movement flows, and other social phenomena. This approach provides practical and tangible benefits for preservation values related to buildings; this strategy may also change how buildings are perceived in other built environments.