bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-022 Outcomes of Aneurysms Embolised with Coils which were Candidates for the Pipeline Flow Diversion Device
Authors: Crimmins M , Banihashemi A , Gobin P 
Published: July 2014

IntroductionWe assessed the outcome of aneurysms which were eligible for treatment using flow diversion device which were treated with detachable coils prior to the adoption of Pipeline.MethodsData was obtained from a retrospective database of endovascularly Cases were sorted into two groups for this study. Group one consisted of aneurysm with a dome ≥10 mm, aneurysm neck ≥ 4 mm, located in the internal carotid artery and its branches (such as the posterior communicating, anterior choroidal, superior hypophyseal, and ophthalmic arteries), in line with criteria set by the FDA for Pipeline utilization. Group two included cases beyond the FDA indication but within institutionally accepted usage criteria (aneurysms of any size located on the side wall of the branches of the carotid artery or middle cerebral (M1), basilar, vertebral and posterior cerebral artery, with an aneurysm neck ≥3 mm or a dome-to-neck-ratio < 1.5, no limits were placed on dome size). Exclusion for either group was a history of aneurysm rupture or previous neurosurgical procedures.ResultsOnly 50% of the FDA group could be completely embolised with 27% requiring retreatment. 53% of institutional criteria patients were completely embolised with an 8.7% retreatment rate. Characteristics of the patients and aneurysms with the outcome of the procedure, both immediate and longer term outcome will be presented. The time from initial endovascular operation to re-treatment by endovascular means at our institution in the 12 cases requiring re-treatment was 12.4 ± 14.0 months.ConclusionCases that met FDA criteria were significantly more likely to require recoiling than institutional criteria. Aneurysms that meet FDA or institutional criteria for a flow diverting stent are difficult to treat, often incompletely embolised with coiling alone and often need more than one embolization procedure. We present our experience with coil embolization in aneurysms that could have been treated with Pipeline flow diverter.DisclosuresM. Crimmins: None. A. Banihashemi: None. P. Gobin: None.
E-026 Time and Pressure - Possible Reasons Behind Worse Outcomes For GETA Patients Undergoing Stroke Interventions
Authors: Rai A , Boo S , Domico J , Roberts T , Carpenter J 
Published: July 2014

BackgroundSeveral publications have shown poor outcomes for GETA patients undergoing endovascular stroke interventions. Our goal was to examine the factors directly related to GETA that may impact procedural outcomes. Our hypothesis being that GETA patients are sicker, the procedure may take longer and there may be fluctuations in blood pressure.MethodologyAn IRB approved retrospective analysis was performed on patients that had undergone stroke interventions over the last 5-years and for whom anesthesia records were available. Blood pressure parameters and time intervals were recorded at multiple steps during a patient’s progress from the ER to the ICU. Patient demographic information and comorbidities were also recorded, as was 90-day clinical outcome.ResultsOut of 190 patients, GETA was administered in 108(56.8%) and non-GETA in 82(43.2%) patients. The mean age was 67.9(±16.2) years in the GETA and 67.1(±17) years in the non-GETA-group (p = 0.7). The mean NIHSS was 18.9(±8.7) in the GETA versus 13.4(6.8) in the non-GETA-group (p < 0.0001). Of the non-GETA group, 34(41.5%) patients were done under conscious sedation (CS) and 48(58.5%) under MAC. A favorable clinical outcome (mRS 0-2) was seen in 35.5% of the GETA-group versus 54.5% of the non-GETA-group (OR 0.4 95%CI: 0.25–0.83, p = 0.01). Mortality was observed in 40.2% of the GETA versus 21.5% of the non-GETA-group (OR 0.4 95%CI: 0.2–0.8, p = 0.006). The recanalization rate was not different across the groups. The intra-procedural pressure fluctuation defined as the difference between the maximum and minimum SBP was 60(±30) points in GETA and 47(±27) points in non-GETA-group (p = 0.02). For the GETA-group, the ΔSBP pre and post-induction was 11.5(±21) points for favorable and 20(±23) points for poor outcomes (p = 0.07). The time to groin puncture from angiography lab arrival time was significantly shorter, 36(±25) minutes in the non-GETA-group versus 53(±32) minutes in the GETA-group (p = 0.0006).ConclusionGETA was associated with worse outcomes and higher mortality, however, GETA patients had also presented with worse deficits and by itself was not an independent predictor of outcome when NIHSS, age and recanalization were taken into account. A significantly higher BP fluctuation was seen in GETA versus non-GETA groups and a higher difference in pre and post-induction SBP portended a poor outcome amongst the GETA-group. Lastly the interval between arrival and groin puncture was significantly longer in GETA patients. At times GETA may be a necessity in sick patients, however, by strictly controlling BP and introducing measures to reduce delay in procedure start time (such as invasive BP monitoring through the femoral sheath), the “adverse” effect of GETA may be countered in endovascular stroke interventions.DisclosuresA. Rai: 2; C; Stryker Neurovascular, Codman Neuro. S. Boo: None. J. Domico: None. T. Roberts: None. J. Carpenter: None.
E-029 WEB Flow Disruption: Preliminary Results from WEBCAST trial
Authors: Pierot L , Spelle L , Costalat V , Szikora I , Klisch J , Herbreteau D , Holtmannspoetter M , Weber W , Liebig T , Cognard C , Bonafé A , Moret J , Byrne J , Molyneux A 
Published: July 2014

Background and purposeWEBCAST is a European study dedicated to the evaluation of the feasibility, safety, and efficacy of endovascular treatment with WEB of intracranial aneurysms.Materials and methodsThe study was conducted in 10 European centers. Inclusion criteria were aneurysms located at internal carotid artery bifurcation, middle cerebral artery, basilar artery, and anterior communicating artery with a neck ≥4 mm and a dome to neck ratio ≥ 1. Recanalized aneurysms were not included. Complications and safety data were independently evaluated. Aneurysm occlusion was evaluated at 6 months with DSA by an independent core lab. Aneurysm occlusion was evaluated stable at 6 months in case of complete occlusion, no modification or improvement of the occlusion (versus post-operative occlusion), and no retreatment was performed or foreseen.ResultsFifty-one patients (36 females and 15 males) with 51 aneurysms were included between December 2011 and February 2014. Age was between 33 and 75 years (55.6 ± 1.5 years). Forty-eight aneurysms were unruptured and 3 ruptured. Aneurysm location was middle cerebral artery (28 aneurysms), basilar artery (12 aneurysms) internal carotid artery (6 aneurysms), and anterior communicating (5 aneurysms).The feasibility, safety, and efficacy of the treatment is analyzed.ConclusionWEBCAST is the first prospective, multicenter trial evaluating the treatment of intracranial aneurysms with WEB Aneurysm Embolization System. Preliminary results are presented.DisclosuresL. Pierot: 2; C; Sequent. L. Spelle: None. V. Costalat: None. I. Szikora: None. J. Klisch: None. D. Herbreteau: None. M. Holtmannspoetter: None. W. Weber: None. T. Liebig: None. C. Cognard: None. A. Bonafé: None. J. Moret: None. J. Byrne: None. A. Molyneux: None.
E-030 Endovascular Treatment with Flow Diverter of Recanalized and Multitreated Aneurysms Initially Treated by Endovascular Approach
Authors: Pierot L , Benaissa A , Januel A , Herbreteau D , Berge J , Aggour M , Cognard C 
Published: July 2014

Background and purposeTo evaluate the feasibility, safety, and efficacy of endovascular treatment with flow diverters (FD) in patients with recanalised and multitreated aneurysms, in a retrospective, multicenter, single-arm study.Materials and methodsThe study included 29 patients with 29 recanalised aneurysms who were treated by FDs (Silk or Pipeline device). Per and post procedural complications and morbidity and mortality rates were evaluated. Additionally, functional outcomes (mRS) at 1 month (short-term) and 3–4 months (mid-term) were compared with pre-operative mRS (before the procedure). Mid-term angiographic follow-up was performed assessing aneurismal occlusion by a 3-grades scale (complete occlusion, neck remnant, aneurysm remnant).ResultsFD placement was achieved in all the patients. Two misdeployments of the FD necessitated balloon dilatation in two patients associated with stent delivery in one patient. Permanent morbidity related to treatment was 6.9% (2/29), transient morbidity was 10.3% (3/29) and mortality due to treatment was 0.0% (0/29). One patient died from a myocardial infarct four weeks after the procedure. 25/29 (86.2%) patients had final good functional outcome, 26/29 (89.7%) patients had unchanged functional outcome, whereas 2/29 (6.9%) patients had clinical worsening. Angiographic follow-up showed complete occlusion in 17/28 patients (60.7%), neck remnants in 6/28 patients (21.4%) and residual aneurysms in 5/28 subjects (17.9%).ConclusionFlow diverter placement is feasible and safe in patients with recanalised and multitreated aneurysms. The procedure is associated with a high percentage of good functional outcomes as well as good anatomical results at mid-term (82.1%).DisclosuresL. Pierot: 2; C; Covidien, Microvention, Stryker. A. Benaissa: None. A. Januel: None. D. Herbreteau: None. J. Berge: None. M. Aggour: None. C. Cognard: None.
Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer
Authors: Dauchy Robert T. , Xiang Shulin , Mao Lulu , Brimer Samantha , Wren Melissa A. , Yuan Lin , Anbalagan Muralidharan , Hauch Adam , Frasch Tripp , Rowan Brian G. , Blask David E. , Hill Steven M. 
Published: July 2014

Abstract
Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer. Preclinical and clinical evidence links resistance to antiestrogen drugs in breast cancer cells with the overexpression and/or activation of various pro-oncogenic tyrosine kinases. Disruption of circadian rhythms by night shift work or disturbed sleep-wake cycles may lead to an increased risk of breast cancer and other diseases. Moreover, light exposure at night (LEN) suppresses the nocturnal production of melatonin that inhibits breast cancer growth. In this study, we used a rat model of estrogen receptor (ERα+) MCF-7 tumor xenografts to demonstrate how altering light/dark cycles with dim LEN (dLEN) speed the development of breast tumors, increasing their metabolism and growth and conferring an intrinsic resistance to tamoxifen therapy. These characteristics were not observed in animals in which the circadian melatonin rhythm was not disrupted, or in animals subjected to dLEN if they received nocturnal melatonin replacement. Strikingly, our results also showed that melatonin acted both as a tumor metabolic inhibitor and a circadian-regulated kinase inhibitor to reestablish the sensitivity of breast tumors to tamoxifen and tumor regression. Together, our findings show how dLEN-mediated disturbances in nocturnal melatonin production can render tumors insensitive to tamoxifen. Cancer Res; 74(15); 4099–110. ©2014 AACR.
A Risk Prediction Model for Smoking Experimentation in Mexican American Youth
Authors: Talluri Rajesh , Wilkinson Anna V. , Spitz Margaret R. , Shete Sanjay 
Published: July 2014

Abstract
Background: Smoking experimentation in Mexican American youth is problematic. In light of the research showing that preventing smoking experimentation is a valid strategy for smoking prevention, there is a need to identify Mexican American youth at high risk for experimentation.
Methods: A prospective population-based cohort of 1,179 adolescents of Mexican descent was followed for 5 years starting in 2005–06. Participants completed a baseline interview at a home visit followed by three telephone interviews at intervals of approximately 6 months and additional interviews at two home visits in 2008–09 and 2010–11. The primary endpoint of interest in this study was smoking experimentation. Information about social, cultural, and behavioral factors (e.g., acculturation, susceptibility to experimentation, home characteristics, and household influences) was collected at baseline using validated questionnaires.
Results: Age, sex, cognitive susceptibility, household smoking behavior, peer influence, neighborhood influence, acculturation, work characteristics, positive outcome expectations, family cohesion, degree of tension, ability to concentrate, and school discipline were found to be associated with smoking experimentation. In a validation dataset, the proposed risk prediction model had an area under the receiver operating characteristic curve (AUC) of 0.719 (95% confidence interval, 0.637–0.801) for predicting absolute risk for smoking experimentation within 1 year.
Conclusions: The proposed risk prediction model is able to quantify the risk of smoking experimentation in Mexican American adolescents.
Impact: Accurately identifying Mexican American adolescents who are at higher risk for smoking experimentation who can be intervened will substantially reduce the incidence of smoking and thereby subsequent health risks. Cancer Epidemiol Biomarkers Prev; 23(10); 2165–74. ©2014 AACR.
Are HIV-Infected Men Vulnerable to Prostate Cancer Treatment Disparities?
Authors: Murphy Adam B. , Bhatia Ramona , Martin Iman K. , Klein David A. , Hollowell Courtney M.P. , Nyame Yaw , Dielubanza Elodi , Achenbach Chad , Kittles Rick A. 
Published: July 2014

Abstract
Background: HIV-infected (HIV+) men face cancer treatment disparities that impact outcome. Prostate cancer treatment and treatment appropriateness in HIV+ men are unknown.
Methods: We used electronic chart review to conduct a retrospective cohort study of 43 HIV+ cases with prostate cancer and 86 age- and race-matched HIV-uninfected (HIV−) controls with prostate cancer, ages 40 to 79 years, from 2001 to 2012. We defined treatment appropriateness using National Comprehensive Cancer Network guidelines and the Charlson comorbidity index (CCI) to estimate life expectancy.
Results: Median age was 59.5 years at prostate cancer diagnosis. Median CD4+ T-cell count was 459.5 cells/mm3, 95.3% received antiretroviral therapy, and 87.1% were virally suppressed. Radical prostatectomy was the primary treatment for 39.5% of HIV+ and 71.0% of HIV− men (P = 0.004). Only 16.3% of HIV+ versus 57.0% of HIV− men received open radical prostatectomy (P &lt; 0.001). HIV+ men received more radiotherapy (25.6% vs. 16.3%, P = 0.13). HIV was negatively associated with open radical prostatectomy (OR = 0.03, P = 0.007), adjusting for insurance and CCI. No men were undertreated. Fewer HIV+ men received appropriate treatment (89.2% vs. 100%, P = 0.003), due to four overtreated HIV+ men. Excluding AIDS from the CCI still resulted in fewer HIV+ men receiving appropriate treatment (94.6% vs. 100%, P = 0.03).
Conclusion: Prostate cancer in HIV+ men is largely appropriately treated. Under- or overtreatment may occur from difficulties in life expectancy estimation. HIV+ men may receive more radiotherapy and fewer radical prostatectomies, specifically open radical prostatectomies.
Impact: Research on HIV/AIDS survival indices and etiologies and outcomes of this prostate cancer treatment disparity in HIV+ men are needed. Cancer Epidemiol Biomarkers Prev; 23(10); 2009–18. ©2014 AACR.
Unbiased Proteomic and Transcript Analyses Reveal that Stathmin-1 Silencing Inhibits Colorectal Cancer Metastasis and Sensitizes to 5-Fluorouracil Treatment
Authors: Wu Wei , Tan Xing Fei , Tan Hwee Tong , Lim Teck Kwang , Chung Maxey Ching Ming 
Published: July 2014

Abstract
Colorectal cancer metastasis is a major cause of mortality worldwide, which may only be controlled with novel methods limiting tumor dissemination and chemoresistance. High stathmin-1 (STMN1) expression was previously established as a hallmark of colorectal cancer progression and predictor of poor survival; however, the mechanism of action is less clear. This work demonstrates that STMN1 silencing arrests tumor-disseminative cascades by inhibiting multiple metastatic drivers, and repressing oncogenic and mesenchymal transcription. Using a sensitive iTRAQ labeling proteomic approach that quantified differential abundance of 4562 proteins, targeting STMN1 expression was shown to reinstate the default cellular program of metastatic inhibition, and promote cellular adhesion via amplification of hemidesmosomal junctions and intermediate filament tethering. Silencing STMN1 also significantly improved chemoresponse to the classical colorectal cancer therapeutic agent, 5FU, via a novel caspase-6 (CASP6)–dependent mechanism. Interestingly, the prometastatic function of STMN1 was independent of p53 but required phosphorylations at S25 or S38; abrogating phosphorylative events may constitute an alternative route to achieving metastatic inhibition. These findings establish STMN1 as a potential target in antimetastatic therapy, and demonstrate the power of an approach coupling proteomics and transcript analyses in the global assessment of treatment benefits and potential side-effects.
Implications: Stathmin-1 is a potential candidate in colorectal cancer therapy that targets simultaneously the twin problems of metastatic spread and chemoresistance. Mol Cancer Res; 12(12); 1717–28. ©2014 AACR.
Acute Rupture of Chordae Tendineae of the Mitral Valve in Infants
Authors: Shiraishi Isao , Nishimura Kunihiro , Sakaguchi Heima , Abe Tadaaki , Kitano Masataka , Kurosaki Kenichi , Kato Hitoshi , Nakanishi Toshio , Yamagishi Hiroyuki , Sagawa Koichi , Ikeda Yoshihiko , Morisaki Takayuki , Hoashi Takaya , Kagisaki Koji , Ichikawa Hajime 
Published: July 2014

Background—
Recently, infant cases of acute heart failure attributable to rupture of the mitral chordae tendineae have been reported. However, little is known about the pathogenesis and clinical course of this condition.

Methods and Results—
Ninety-five children with rupture of mitral chordae tendineae were identified in nationwide surveys of Japan diagnosed from 1995 to 2013. The clinical manifestations, management strategies, and prognosis were investigated. Eighty-one (85%) patients were between 4 and 6 months (median, 5 months) of age. In 63 (66%) patients, rupture occurred during the spring or summer. The underlying conditions before rupture included Kawasaki disease (10 cases), maternally derived anti-SSA antibodies (2 cases), and infective endocarditis (1 case). Surgery was performed in 80 patients (94 operations), and the final operations included plasty of mitral chordae in 52 cases and mechanical valve replacement in 26 cases. The histopathologic examinations of the mitral valves and chordae (n=28) revealed inflammatory reactions with predominant mononuclear cell infiltration in 18 cases (64%) and increased fibrous and myxoid tissue in 11 cases (39%), suggesting that nonbacterial infectious or autoimmune endocarditis and myxoid changes are involved in the pathogenesis. Eight patients (8.4%) died before (n=6) and shortly after (n=2) the operation, and significant neurological complications persisted in 10 cases (11%).

Conclusions—
Acute heart failure attributable to rupture of the mitral chordae tendineae in infants is a unique disease resulting from diverse causes. This condition should be recognized as a significant cardiovascular disorder that may cause sudden onset of cardiogenic shock and death in infants.
The effect of lactation educators implementing a telephone-based intervention among low-income Hispanics: A randomised trial
Authors: Efrat Merav W , Esparza Salvador , Mendelson Sherri G , Lane Christianne J 
Published: July 2014

Objectives: To assess whether a telephone-based breastfeeding intervention delivered by lactation educators influenced exclusive breastfeeding rates among low-income Hispanic women in the USA. Design: Randomised two-group design. Setting: Pregnant low-income Hispanic women (298) were recruited from community health clinics in Los Angeles County (USA) and randomly assigned to either a control or an intervention group. Methods: Data relating to the factors associated with breastfeeding were collected during the third trimester. Breastfeeding outcome data were collected at 72 hours, 1 month, 3 months and 6 months postpartum. Results: There were no differences between the groups in rates of breastfeeding initiation. There was a significant difference in the duration of exclusive breastfeeding among participants during the infant’s first week of life. While not significant, after controlling for covariates and intent to breastfeed at third trimester, the duration of exclusive breastfeeding among all participants was, on average, longer for intervention group mothers than control group mothers. Additionally, the intervention group mothers were more likely to report exclusive and only breastfeeding at all data points compared to the control group and less likely to discontinue breastfeeding. Conclusion: Findings from this study suggest that telephone-based breastfeeding interventions delivered by a lactation educator show promise as a cost-effective strategy for improving both the quantity and the duration of breastfeeding among low-income Hispanic women in the USA. Intervention group mothers not only sustained breastfeeding for a longer durations but also provided their infants with greater amounts of breast milk over these longer durations.
Psychiatric morbidity and predisposing factors in a primary care population in Madrid
Authors: Reneses Banca , Garrido Sofía , Navalón Aida , Martín Olga , Ramos Isabel , Fuentes Manuel , Moreno Jorge , López-Ibor Juan José 
Published: July 2014

Objectives: The aim of this article is to estimate the prevalence of mental disorders in patients in primary care centers in an urban area of Madrid and to study possible associated risk factors. Methods: Cross-sectional month prevalence was evaluated in two phases in an urban area of Madrid. The sample for the first phase included 635 individuals (aged 18–65 years), and the second phase included 320 individuals. Socio-demographic variables (age, sex, educational level, living conditions and country of origin) and clinical variables (psychiatric diagnosis and level of psychosocial stress) were studied. The instruments used for screening were the General Health Questionnaire (GHQ)-28 item questionnaire and the MULTICAGE-CAD 4test. The Mini International Neuropsychiatric Interview (M.I.N.I.) was used in the second phase (in ‘possible cases’ and 20% of the ‘non-cases’). Prevalence was calculated using weighted logistic regression with the observed sampling fractions of the patients in study phase 2 as sample weights. Results and conclusions: The month prevalence of mental disorders was 31.3% (95% confidence interval (CI) = [27.6, 35.2]). Anxiety disorders were the most frequent diagnoses with a prevalence of 22.4% (95% CI = [17.8, 27.1]), followed by depressive disorders (16.6%; 95% CI = [12.9, 20.3]), substance abuse or dependence disorders (5.6%; 95% CI = [3.2, 6.9]) and posttraumatic stress disorder (PTSD; 4.4%; 95% CI = [2.0, 2.8]). Factors associated with mental disorders were the presence of stressful life events in the previous 12 months, Latin American region of origin, being woman aged 25 and 34 years and having a low education level.