bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Proposed Guidelines for Early Identification of Successful Myeloid and Erythroid Engraftment in Hematopoietic Stem Cell Transplantation
Authors: Yahng Seung‐Ah , Lee Jae Wook , Kim Yonggoo , Kim Myungshin , Oh Eun‐Jee , Park Yeon‐Joon , Lee Jong Wook , Cho Bin , Han Kyungja 
Published: March 2014

BackgroundAfter hematopoietic stem cell transplantation (HSCT), early detection of engraftment would be of critical value for clinicians. The aim of this study was to identify faster parameters for engraftment.MethodsWe evaluated blood cell parameters including complete blood count (CBC), differential counts, and various reticulocyte parameters in 115 patients who received HSCT (allogeneic, n = 93; autologous, n = 22) in the purpose of identifying possible improved laboratory guidelines for engraftment prediction.Results and ConclusionDays to white blood cell (WBC) count over 100 cells/μl with more than two‐fold increase from nadir after transplantation (proposed new WBC guideline) preceded absolute neutrophil count (ANC) >500 cells/μl by 1.7 days. Among erythroid parameters, the earliest marker for erythroid engraftment was high light scattering reticulocytes (HLR) >0.1 (proposed new red blood cell guideline), which preceded reticulocyte counts (RET) >1% and immature reticulocyte fraction >0.5 by 3.9 and 1.6 days, respectively. Among the clinical parameters compared, those with statistically significant influence on myeloid engraftment were donor type (P = 0.009) and conditioning intensity (P = 0.009). As for erythroid recovery, ABO incompatibility was the only significant factor. In conclusion, the new guidelines may ensure engraftment several days earlier than the conventional parameters, which may help clinicians for decision‐making on rescue therapy earlier.
Serum Vascular Endothelial Growth Factor, Transforming Growth Factor β1, and Nitric Oxide Levels in Patients With Psoriasis Vulgaris: Their Correlation to Disease Severity
Authors: Meki Abdel‐Raheim M. A. , Al‐Shobaili Hani 
Published: March 2014

BackgroundVascular endothelial growth factor (VEGF), transforming growth factor β1 (TGF‐β1), and nitric oxide (NO) have been reported to be contributory factors to the pathogenesis of psoriasis vulgaris. In the current study, we aimed to investigate the association between the levels of VEGF, TGF‐β1, and NO and psoriasis severity (as expressed by psoriasis area severity index, PASI).MethodsFifty‐eight patients with psoriasis vulgaris and twenty‐two controls were included in the study. The serum levels of VEGF and TGF‐β1 were estimated by ELISA technique. The serum levels of NO were determined by colorimetric method.ResultsThe serum levels of VEGF, TGF‐β1, and NO were significantly higher in patients than controls. Moreover, the serum levels of the studied biochemical variables in patients with severe disease activity were significantly higher than mild cases. The duration of disease showed significant positive correlations with each VEGF (r = 0.35, P < 0.01) and TGF‐β1 (r = 0.41, P < 0.05). In addition, the PASI score was significantly positively correlated with VEGF (r = 0.65, P < 0.001), TGF‐β1 (r = 0.31, P < 0.05), and NO (r = 0.51, P < 0.001).ConclusionThese findings suggest an association between psoriasis disease severity and serum levels of VEGF, TGF‐β1, and NO, which can be recognized as markers of the psoriasis severity. The modulation of their production may represent a therapeutic potential strategy for psoriasis.
Using standardized videos to validate a measure of handoff quality: The handoff mini‐clinical examination exercise
Authors: Arora Vineet M. , Berhie Saba , Horwitz Leora I. , Saathoff Mark , Staisiunas Paul , Farnan Jeanne M. 
Published: March 2014

BACKGROUNDThe most recent iteration of the Accreditation Council for Graduate Medical Education duty‐hour regulations includes language mandating handoff education for trainees and assessments of handoff quality by residency training programs. However, there is a lack of validated tools for the assessment of handoff quality and for use in trainee education.METHODSFaculty at 2 sites (University of Chicago and Yale University) were recruited to participate in a workshop on handoff education. Video‐based scenarios were developed to represent varying levels of performance in the domains of communication, professionalism, and setting. Videos were shown in a random order, and faculty were instructed to use the Handoff Mini‐Clinical Examination Exercise (CEX), a paper‐based instrument with qualitative anchors defining each level of performance, to rate the handoffs.RESULTSForty‐seven faculty members (14 at site 1; 33 at site 2) participated in the validation workshops, providing a total of 172 observations (of a possible 191 [96%]). Reliability testing revealed a Cronbach α of 0.81 and Kendall coefficient of concordance of 0.59 (>0.6 = high reliability). Faculty were able to reliably distinguish the different levels of performance in each domain in a statistically significant fashion (ie, unsatisfactory professionalism mean 2.42 vs satisfactory professionalism 4.81 vs superior professionalism 6.01, P < 0.001 trend test). Two‐way analysis of variance revealed no evidence of rater bias.CONCLUSIONSUsing standardized video‐based scenarios highlighting differing levels of performance, we were able to demonstrate evidence that the Handoff Mini‐CEX can draw reliable and valid conclusions regarding handoff performance. Future work to validate the tool in clinical settings is warranted. Journal of Hospital Medicine 2014;9:441–446. © 2014 Society of Hospital Medicine
Transcriptional regulators TRIM28, SETDB1, and TP53 are aberrantly expressed in porcine embryos produced by in vitro fertilization in comparison to in vivo‐ and somatic‐cell nuclear transfer‐derived embryos
Authors: Hamm Jennifer , Tessanne Kim , Murphy Clifton N. , Prather Randall S. 
Published: March 2014

SUMMARYIn vitro embryo production is important for research in animal reproduction, embryo transfer, transgenics, and cloning. Yet, in vitro‐fertilized (IVF) embryos are generally developmentally delayed and are inferior to in vivo‐derived (IVV) embryos; this discrepancy is likely a result of aberrant gene expression. Transcription of three genes implicated to be important in normal preimplantation embryo development, TRIM28, SETDB1, and TP53, was determined by quanitative PCR in IVF, somatic‐cell nuclear transfer (SCNT), parthenogenetic, and IVV porcine oocytes and embryos. There was no difference in TRIM28 or SETDB1 abundance between oocytes matured in vitro versus in vivo (P > 0.05), whereas TP53 levels were higher in in vitro‐matured oocytes. TRIM28 increased from metaphase‐II oocytes to the 4‐cell and blastocyst stages in IVF embryos, whereas IVV embryos showed a reduction in TRIM28 abundance from maturation throughout development. The relative abundance of TP53 increased by the blastocyst stage in all treatment groups, but was higher in IVF embryos compared to IVV and SCNT embryos. In contrast, SETDB1 transcript levels decreased from the 2‐cell to blastocyst stage in all treatments. For each gene analyzed, SCNT embryos of both hard‐to‐clone and easy‐to‐clone cell lines were more comparable to IVV than IVF embryos. Knockdown of TRIM28 also had no effect on blastocyst development or expression of SETDB1 or TP53. Thus, TRIM28, SETDB1, and TP53 are dynamically expressed in porcine oocytes and embryos. Furthermore, TRIM28 and TP53 abundances in IVV and SCNT embryos are similar, but different from quantities in IVF embryos. Mol. Reprod. Dev. 81: 552–556, 2014. © 2014 The Authors. Published by Wiley Periodicals, Inc.
Strong sp–d exchange coupling in ZnMnTe/ZnMgTe core/shell nanowires
Authors: Wojnar Piotr , Janik Elzbieta , Suffczyński Jan , Papierska Joanna , Szymura Małgorzata , Zaleszczyk Wojciech , Kret Sławomir , Kłopotowski Łukasz , Wojciechowski Tomasz , Baczewski Lech T. , Wiater Maciej , Karczewski Grzegorz , Wojtowicz Tomasz , Kossut Jacek 
Published: March 2014

AbstractIn this work, our recent progress in the growth and optical studies of telluride nanowire heterostructures containing a small molar fraction of magnetic Mn‐ions of only a few percent is overviewed. ZnMnTe/ZnMgTe core/shell nanowires (NWs) are grown by molecular beam epitaxy by employing the vapor‐liquid‐solid growth mechanism assisted with gold catalyst. The structures are studied by means of photoluminescence and microphotoluminescence in an external magnetic field. In the first step, however, an activation of the near band edge emission from ZnTe and ZnMnTe nanowires is described, which is achieved by coating the nanowires with shells made of ZnMgTe. The role of these shells is to passivate Zn(Mn)Te surface states. The incorporation of Mn ions into the crystalline lattice of ZnMnTe nanowires is manifested as a considerable blue shift of near band edge emission with increasing Mn concentration inside the nanowire cores, which reflects directly the increase of their energy gap. In an external magnetic field the near band edge emission exhibits a giant spectral redshift accompanied by an increase of the circular polarization of the emitted light. Both effect are fingerprints of giant Zeeman splitting of the band edges due to sp‐d exchange interaction between the band carriers and magnetic Mn‐ions. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Vapor‐phase epitaxial growth of thick single crystal CdTe on Si substrate for X‐ray, gamma ray spectroscopic detector development
Authors: Niraula Madan , Yasuda Kazuhito , Yamashita Hayate , Wajima Yuto , Tsukamoto Yudai , Matsumoto Masahiko , Suzuki Yuta , Takai Noriaki , Tsukamoto Yuki , Agata Yasunori 
Published: March 2014

AbstractWe investigated MOVPE growth conditions to grow large‐area and thick single crystal CdTe layers with uniform material properties directly on (211) Si substrates to develop nuclear radiation detectors. We found that group VI/II precursor flow‐ratio as well as rapid thermal annealing performed by interrupting the growth at the initial stage has marked influence on the crystal quality. By using a VI/II precursor ratio of 3.0, and a 900 °C anneal performed in flowing hydrogen, we were able to achieve 1‐sq inch sized thick single crystal CdTe that showed uniform material properties and high crystal quality throughout the wafer. We further demonstrated that the grown crystals were suitable for fabricating nuclear radiation detector. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Spatial normalization of ultrahigh resolution 7 T magnetic resonance imaging data of the postmortem human subthalamic nucleus: a multistage approach
Authors: Weiss Marcel , Alkemade Anneke , Keuken Max C. , Műller-Axt Christa , Geyer Stefan , Turner Robert , Forstmann Birte U. 
Published: March 2014

Abstract
In this paper, we describe a novel processing strategy for the spatial normalization of ultrahigh resolution magnetic resonance imaging (MRI) data of small ex vivo samples into MNI standard space. We present a multistage scanning and registration method for data of the subthalamic nucleus (STN) obtained using ultrahigh 7 T MRI on four human postmortem brain samples. Four whole brains were obtained and subjected to multistage MRI scanning, corresponding to four different brain dissection stages. Data sets were acquired with an isotropic resolution of 100 μm enabling accurate manual segmentation of the STN. Spatial normalization to MNI reference space was performed, probability maps were calculated, and results were cross-checked with an independent in vivo dataset showing significant overlay. Normalization of results obtained from small tissue samples into MNI standard space will facilitate comparison between individual subjects, as well as between studies. When combining ultrahigh resolution MRI of ex vivo samples with histological studies via blockface imaging, our method enables further insight and inference as multimodal data can be compared within the same reference space. This novel technique may be of value for research purposes using functional MRI techniques, and in the future may be of assistance for anatomical orientation in clinical practice.
Overexpression of Aspergillus tubingensis faeA in protease-deficient Aspergillus niger enables ferulic acid production from plant material
Authors: Zwane Eunice N , Rose Shaunita H , van Zyl Willem H , Rumbold Karl , Viljoen-Bloom Marinda 
Published: March 2014

Abstract
The production of ferulic acid esterase involved in the release of ferulic acid side groups from xylan was investigated in strains of Aspergillus tubingensis, Aspergillus carneus, Aspergillus niger and Rhizopus oryzae. The highest activity on triticale bran as sole carbon source was observed with the A. tubingensis T8.4 strain, which produced a type A ferulic acid esterase active against methyl p-coumarate, methyl ferulate and methyl sinapate. The activity of the A. tubingensis ferulic acid esterase (AtFAEA) was inhibited twofold by glucose and induced twofold in the presence of maize bran. An initial accumulation of endoglucanase was followed by the production of endoxylanase, suggesting a combined action with ferulic acid esterase on maize bran. A genomic copy of the A. tubingensis faeA gene was cloned and expressed in A. niger D15#26 under the control of the A. niger gpd promoter. The recombinant strain has reduced protease activity and does not acidify the media, therefore promoting high-level expression of recombinant enzymes. It produced 13.5 U/ml FAEA after 5 days on autoclaved maize bran as sole carbon source, which was threefold higher than for the A. tubingensis donor strain. The recombinant AtFAEA was able to extract 50 % of the available ferulic acid from non-pretreated maize bran, making this enzyme suitable for the biological production of ferulic acid from lignocellulosic plant material.
The effects of goal progress cues: An implicit theory perspective
Authors: Mathur Pragya , Block Lauren , Yucel‐Aybat Ozge 
Published: March 2014

AbstractConsumers often encounter goods and services that provide cues to mark their progress. We define the term “goal progress cues” to reflect the diverse category of cues that highlight progress towards a goal. Across a series of three studies, we show that entity theorists, who rely on cues that highlight completion in order to signal their abilities to others, evaluate tasks that include these cues more favorably than those that lack these features. In contrast, incremental theorists, who focus on improving competence, are impacted only by progress cues that highlight learning. We demonstrate these findings across a variety of goal pursuit contexts that represent a mix of customer‐centric (retail queues), service‐oriented managerial (sales calls), and personal achievement consumer product (mazes) domains using both behavioral and self‐reported measures. We conclude with a discussion about the theoretical and substantive implications of our findings.
Fluid injection into a confined porous layer
Authors: Pegler Samuel S. , Huppert Herbert E. , Neufeld Jerome A. 
Published: March 2014

AbstractWe present a theoretical and experimental study of viscous flows injected into a porous medium that is confined vertically by horizontal impermeable boundaries and filled with an ambient fluid of different density and viscosity. General three-dimensional equations describing such flows are developed, showing that the dynamics can be affected by two separate contributions: spreading due to gradients in hydrostatic pressure, and that due to the pressure drop introduced by the injection. In the illustrative case of a two-dimensional injection of fluid at a constant volumetric rate, the injected fluid initially forms a viscous gravity current insensitive both to the depth of the medium and to the viscosity of the ambient fluid. Beyond a characteristic time scale, the dynamics transition to being dominated by the injection pressure, and the injected fluid eventually intersects the second boundary to form a second moving contact line. Three different late-time asymptotic regimes can emerge, depending on whether the viscosity of the injected fluid is less than, equal to or greater than that of the ambient fluid. With a less viscous injection, the flow undergoes a slow decay towards a similarity solution in which the two contact lines extend linearly in time with differing prefactors. Perturbations from this long-term state are shown to decay algebraically with time. Equal viscosities result in both contact lines approaching the same leading-order asymptotic position but with a first-order correction to the distance between them that expands as $t^{1/2}$ due to gravitational spreading. For a more viscous injection, the distance between the contact lines approaches a constant value, with perturbations decaying exponentially. Data from a new series of laboratory experiments confirm these theoretical predictions.
Synchronous precessional motion of multiple domain walls in a ferromagnetic nanowire by perpendicular field pulses
Authors: Kim June-Seo , Mawass Mohamad-Assaad , Bisig André , Krüger Benjamin , Reeve Robert M. , Schulz Tomek , Büttner Felix , Yoon Jungbum , You Chun-Yeol , Weigand Markus , Stoll Hermann , Schütz Gisela , Swagten Henk J. M. , Koopmans Bert , Eisebitt Stefan , Kläui Mathias 
Published: March 2014

AbstractMagnetic storage and logic devices based on magnetic domain wall motion rely on the precise and synchronous displacement of multiple domain walls. The conventional approach using magnetic fields does not allow for the synchronous motion of multiple domains. As an alternative method, synchronous current-induced domain wall motion was studied, but the required high-current densities prevent widespread use in devices. Here we demonstrate a radically different approach: we use out-of-plane magnetic field pulses to move in-plane domains, thus combining field-induced magnetization dynamics with the ability to move neighbouring domain walls in the same direction. Micromagnetic simulations suggest that synchronous permanent displacement of multiple magnetic walls can be achieved by using transverse domain walls with identical chirality combined with regular pinning sites and an asymmetric pulse. By performing scanning transmission X-ray microscopy, we are able to experimentally demonstrate in-plane magnetized domain wall motion due to out-of-plane magnetic field pulses.
Single camera-based synchronisation within a concept of robotic assembly in motion
Authors: Schmitt Robert , Cai Yu 
Published: March 2014

Purpose
– Automated robotic assembly on a moving workpiece, referred to as assembly in motion, demands that an assembly robot is synchronised in all degrees of freedom to the moving workpiece, on which assembly parts are installed. Currently, this requirement cannot be met due to the lack of robust estimation of 3D positions and the trajectory of the moving workpiece. The purpose of this paper is to develop a camera system that measures the 3D trajectory of the moving workpiece for robotic assembly in motion.

Design/methodology/approach
– For the trajectory estimation, an assembly robot-guided, monocular camera system is developed. The motion trajectory of a workpiece is estimated, as the trajectory is considered as a linear combination of trajectory bases, such as discrete cosine transform bases.

Findings
– The developed camera system for trajectory estimation is tested within the robotic assembly of a cylinder block in motion. The experimental results show that the proposed method is able to reconstruct arbitrary trajectories of an assembly point on a workpiece moving in 3D space.

Research limitations/implications
– With the developed technology, a point trajectory can be recovered offline only after all measurement images are acquired. For practical assembly tasks in real production, this method should be extended to determine the trajectory online during the motion of a workpiece.

Practical implications
– For practical, robotic assembly in motion, such as assembling tires, wheels and windscreens on conveyed vehicle bodies, the developed technology can be used for positioning a moving workpiece, which is in the distant field of an assembly robot.

Originality/value
– Besides laser trackers, indoor global positioning systems and stereo cameras, this paper provides a solution of trajectory estimation by using a monocular camera system.
Mathematical performance analysis for HCoP-B reactive fast handover mechanisms for the nested mobile networks
Authors: Chang Ing-Chau , Lu Ciou-Song , Wang Sheng-Chih 
Published: March 2014

Purpose– In the past, by adopting the handover prediction concept of the fast mobile IPv6, the authors have proposed a cross-layer architecture, which was called the proactive fast HCoP-B (FHCoP-B), to trigger layer 3 HCoP-B route optimization flow by 802.11 and 802.16 link events before the actual layer 2 handover of a mobile subnet in the nested mobile network (NEMO) occurs. In this way, proactive FHCoP-B has shortened its handover latency and packet loss. However, there are two scenarios where proactive FHCoP-B cannot normally complete its operations due to fast movements of the NEMO during handover. The paper aims to discuss these issues.Design/methodology/approach– In this paper, the authors will propose efficient reactive FHCoP-B flows for these two scenarios to support fast and seamless handovers. The authors will further extend the analytical model proposed for mobile IPv6 to investigate four performance metrics of proactive and reactive FHCoP-B, HCoP-B and two well-known NEMO schemes with the radio link protocol (RLP), which can detect packet losses and performs retransmissions over the error-prone wireless link.Findings– Through intensive simulations, the authors conclude that FHCoP-B outperforms HCoP-B and the other two well-known NEMO schemes by achieving the shortest handover latencies, the smallest number of packet losses and the fewest playback interruption time during handover only with few extra buffer spaces, even over error-prone wireless links of the nested NEMO.Originality/value– This paper has three major contributions, which are rare in the NEMO literature. First, the proactive FHCoP-B has been enhanced as the reactive one to handle two fast handover scenarios with RLP for the nested NEMO. Second, the reactive FHCoP-B supports seamless reactive handover for the nested NEMO over error-prone wireless links. Third, mathematical performance analyses for two scenarios of reactive FHCoP-B with RLP over error-prone wireless links have been conducted.