bluuebunny/crossref_metadata_2025_split huggingface dataset:
The time evolution of the ultraviolet habitable zone
Authors: Spinelli R , Borsa F , Ghirlanda G , Ghisellini G , Haardt F , Rigamonti F 
Published: July 2024

ABSTRACT
For stars hosting Circumstellar Habitable Zone (CHZ) exoplanets, we investigate the time evolution of their ultraviolet habitable zone (UHZ), the annular region around a star where an exoplanet could experience a suitable ultraviolet environment for the presence and emergence of life, and the possible intersection of the UHZ with the CHZ. To estimate their ultraviolet (UV) luminosity evolution, and therefore the evolution of their UHZ, we analyse Swift-UV/Optical telescope observations and adopt the near-UV luminosity evolutionary tracks derived using GALEX observations of young moving groups. We find that an intersection between CHZ and UHZ could exist (or have existed) around all stars of our sample at different epochs, except for the coldest M-dwarfs (temperature $\lesssim 2800$ K, e.g. Trappist-1). For hotter M-dwarfs the formation of ribonucleic acid precursors through cyanosulfidic chemistry triggered by near-UV radiation could occur during the first $\simeq$1–2 Gyr. The radial extension and time duration of the CHZ–UHZ intersection increase with the stellar effective temperature and the exoplanet atmospheric transmissivity at near-UV wavelengths. Within our sample, Proxima Centauri represents a golden target for the quest of life outside the Solar system because it experienced a long-lasting and more extended, compared to similar M-dwarfs, CHZ–UHZ intersection.
CilioGenics: an integrated method and database for predicting novel ciliary genes
Authors: Pir Mustafa S , Begar Efe , Yenisert Ferhan , Demirci Hasan C , Korkmaz Mustafa E , Karaman Asli , Tsiropoulou Sofia , Firat-Karalar Elif Nur , Blacque Oliver E , Oner Sukru S , Doluca Osman , Cevik Sebiha , Kaplan Oktay I 
Published: July 2024

Abstract
Uncovering the full list of human ciliary genes holds enormous promise for the diagnosis of cilia-related human diseases, collectively known as ciliopathies. Currently, genetic diagnoses of many ciliopathies remain incomplete (1–3). While various independent approaches theoretically have the potential to reveal the entire list of ciliary genes, approximately 30% of the genes on the ciliary gene list still stand as ciliary candidates (4,5). These methods, however, have mainly relied on a single strategy to uncover ciliary candidate genes, making the categorization challenging due to variations in quality and distinct capabilities demonstrated by different methodologies. Here, we develop a method called CilioGenics that combines several methodologies (single-cell RNA sequencing, protein-protein interactions (PPIs), comparative genomics, transcription factor (TF) network analysis, and text mining) to predict the ciliary capacity of each human gene. Our combined approach provides a CilioGenics score for every human gene that represents the probability that it will become a ciliary gene. Compared to methods that rely on a single method, CilioGenics performs better in its capacity to predict ciliary genes. Our top 500 gene list includes 258 new ciliary candidates, with 31 validated experimentally by us and others. Users may explore the whole list of human genes and CilioGenics scores on the CilioGenics database (https://ciliogenics.com/).
Right proximal tibia post-traumatic lipoma following a jogging fall
Authors: Parinyakhup Wachiraphan , Boonriong Tanarat , Boonsri Pattira , Chuaychoosakoon Chaiwat 
Published: July 2024

Abstract
This case report describes a 70-year-old woman who presented with a lump at the right knee. She had had a fall while jogging two years previously, followed by the development of a painless mass at the injury site. The mass had gradually increased in size over time. At presentation the physical examination revealed a soft, ill-defined mass, and magnetic resonance imaging confirmed a well-circumscribed subcutaneous soft tissue mass consistent with a lipoma. Given the asymptomatic nature and well-defined characteristics of the mass, the patient opted for conservative management with observation. This case highlights the importance of considering post-traumatic lipoma in the differential diagnosis of soft tissue masses, particularly in patients with a history of trauma. Such masses should be regularly monitored to allow timely intervention if indicated.
Analysis of Ion Transport Properties of Glycine max HKT Transporters and Identifying a Regulation of GmHKT1;1 by the Non-Functional GmHKT1;4
Authors: Liu Liu , Luo Sheng , Ma Longfei , Zhang Yanli , Wang Tiantian , Wang Jicheng , Liang Xiushuo , Xue Shaowu 
Published: July 2024

Abstract
High-affinity potassium transporters (HKTs) play an important role in plants responding to salt stress, but the transport properties of the soybean HKT transporters at the molecular level are still unclear. Here, using Xenopus oocyte as a heterologous expression system and two-electrode voltage-clamp technique, we identified four HKT transporters, GmHKT1;1, GmHKT1;2, GmHKT1;3 and GmHKT1;4, all of which belong to type I subfamily, but have distinct ion transport properties. While GmHKT1;1, GmHKT1;2 and GmHKT1;3 function as Na+ transporters, GmHKT1;1 is less selective against K+ than the two other transporters. Astonishingly, GmHKT1;4, which lacks transmembrane segments and has no ion permeability, is significantly expressed, and its gene expression pattern is different from the other three GmHKTs under salt stress. Interestingly, GmHKT1;4 reduced the Na+/K+ currents mediated by GmHKT1;1. Further study showed that the transport ability of GmHKT1;1 regulated by GmHKT1;4 was related to the structural differences in the first intracellular domain and the fourth repeat domain. Overall, we have identified one unique GmHKT member, GmHKT1;4, which modulates the Na+ and K+ transport ability of GmHKT1;1 via direct interaction. Thus, we have revealed a new type of HKT interaction model for altering their ion transport properties.
Two calcium sensor-activated kinases function in root hair growth
Authors: Fang Xianming , Liu Beibei , Kong Haiyan , Zeng Jingyou , Feng Yixin , Xiao Chengbin , Shao Qianshuo , Huang Xuemei , Wu Yujun , Bao Aike , Li Jia , Luan Sheng , He Kai 
Published: July 2024

Abstract
Plant pollen tubes and root hairs typically polarized tip growth. It is well established that calcium ions (Ca2+) play essential roles in maintaining cell polarity and guiding cell growth orientation. Ca2+ signals are encoded by Ca2+ channels and transporters and are decoded by a variety of Ca2+-binding proteins often called Ca2+ sensors, in which calcineurin B-like protein (CBL) proteins function by interacting with and activating a group of kinases and activate CBL-interacting protein kinases (CIPKs). Some CBL-CIPK complexes, such as CBL2/3-CIPK12/19, act as crucial regulators of pollen tube growth. Whether these calcium decoding components regulate the growth of root hairs, another type of plant cell featuring Ca2+-regulated polarized growth, remains unknown. In this study, we identified CIPK13 and CIPK18 as genes specifically expressed in Arabidopsis (Arabidopsis thaliana) root hairs. The cipk13 cipk18 double mutants showed reduced root hair length and lower growth rates. The calcium oscillations at the root hair tip were attenuated in the cipk13 cipk18 mutants as compared to the wild-type plants. Through yeast 2-hybrid screens, CBL2 and CBL3 were identified as interacting with CIPK13 and CIPK18. cbl2 cbl3 displayed a shortened root hair phenotype similar to cipk13 cipk18. This genetic analysis, together with biochemical assays showing activation of CIPK13/18 by CBL2/3, supported the conclusion that CBL2/3 and CIPK13/18 may work as Ca2+-decoding modules in controlling root hair growth. Thus, the findings that CIPK12/19 and CIPK13/18 function in pollen tube and root hair growth, respectively, illustrate a molecular mechanism in which the same CBLs recruit distinct CIPKs in regulating polarized tip growth in different types of plant cells.
One-Loop Contributions for A0 → ℓℓ̄V with ℓ ≡ e, μ and V ≡ γ , Z in Higgs Extensions of the Standard Model
Authors: Phan Khiem Hong , Tran Dzung Tri , Nguyen Thanh Huy 
Published: July 2024

Abstract
We present one-loop formulas for the decay of the CP-odd Higgs $A^0 \rightarrow \ell \bar{\ell } V$ with $\ell \equiv e, \mu$ and $V\equiv \gamma , Z$ in Higgs extensions of the Standard Model, considering a two Higgs doublet model with an extra complex (and real) scalar, a two Higgs doublet model as well as a triplet Higgs model. Analytic results for one-loop amplitudes are expressed in terms of the basic Passarino–Veltman functions following the standard notations of LoopTools. As a result, physical results can be generated numerically by using the package. In the phenomenological results, the total decay widths and the differential decay rates with respect to the invariant mass of a lepton pair are analyzed for two typical models such as the two Higgs doublet model and the triplet Higgs model.
Distance to climate targets in agriculture in the EU
Authors: Spiegel Alisa , Heidecke Claudia , Osterburg Bernhard 
Published: July 2024

Abstract
In the European Union (EU), national climate targets are formulated for aggregate sectors under the Effort-Sharing Regulation (ESR), incl. agriculture. We perform a cross-country analysis of current progress of the EU Member States (MSs) in reaching climate targets for 2030 in agriculture. Observing a remarkable heterogeneity within the EU, we allocated EU MSs into two homogeneous clusters: (1) EU MSs with relatively large distances to climate targets and/or poor progress over the years and (2) EU MSs with relatively small distances to climate targets and/or good progress. We discovered that the first cluster is characterised by more ambitious ESR targets, limited ability to reduce greenhouse gas emissions by increasing efficiency, and a higher share of mitigation measures that have not been implemented yet. These MSs furthermore pursue a wider range of goals, such as increasing biodiversity, ensuring sustainability, which is in line with the multifaceted role of the agricultural sector.
The Framing of Minority Threat and Moralization to Criminalize Behavior: The Case of Cannabis in the Early 20th Century
Authors: Vuolo Mike , Kelly Brian C , Orsini Maria M , Kadowaki Joy 
Published: July 2024

Abstract
Understanding why particular behavior is encoded in law or other systems of rules has been a core topic of sociology since its inception. Although differing rhetorical frames have been identified in policy debates, little research directly links such rhetoric and policy passage. Centering framing theory, we use the case of U.S. cannabis criminalization via mixed-methods content analyses of 9,707 nationwide newspaper articles and event history analysis of state-level criminalization to make several contributions. First, we go beyond describing rhetorical frames, demonstrating that core framing tasks were associated with spatial and temporal state-level cannabis law passage. Second, we emphasize that consolidation of two “master frames,” legal and racial, are particularly pertinent to criminalization and permit incorporation of rhetorical minority threat into framing. Third, an overreliance on population-based minority threat exists in the literature; however, threat can operate absent minority groups. While demonstrating the effect of vilification of Mexican people, we show that a heterogeneous “othering” of cannabis, by attaching threat to numerous minority groups, was significant for cannabis criminalization, regardless of minority groups’ actual presence. In addition to interrogating longstanding assumptions regarding cannabis criminalization, our analyses demonstrate the importance of framing and rhetorical racial threat in the social construction of law.
Libres propos sur l’internationalité dans l’arbitrage OHADA
Authors: Ngono Véronique Carole 
Published: July 2024

Abstract
OHADA arbitration has a special relationship with internationality. While the distinction between domestic and international arbitration has been abolished, thus enshrining legal monism, the uniform rules are intended to encompass the specific features of arbitration induced by factors of internationality. This solution is not only theoretically inadequate, because OHADA is not a State but a group of States, which means that conflicts of law remain, but it also restricts the development of international arbitration. It is therefore essential to combine the desire to apply a single legal regime with the need to take internationality into account, in order to make OHADA arbitration law more attractive.
Cannabis Use and Inhalational Anesthesia Administration in Older Adults
Authors: Sajdeya Ruba , Rouhizadeh Masoud , Cook Robert L. , Ison Ronald L. , Bai Chen , Jugl Sebastian , Gao Hanzhi , Mardini Mamoun T. , Zandbiglari Kimia , Adiba Farzana I. , Dasa Osama , Winterstein Almut G. , Price Catherine C. , Pearson Thomas A. , Seubert Christoph N. , Tighe Patrick J. 
Published: July 2024

Background:
Cannabis use is associated with higher intravenous anesthetic administration. Similar data regarding inhalational anesthetics are limited. With rising cannabis use prevalence, understanding any potential relationship with inhalational anesthetic dosing is crucial. We compared average intraoperative isoflurane/sevoflurane minimum alveolar concentration equivalents between older adults with and without cannabis use.

Methods:
The electronic health records of 22,476 surgical patients ≥65 years old at the University of Florida Health System between 2018-2020 were reviewed. The primary exposure was cannabis use within 60 days of surgery, determined via i) a previously published natural language processing algorithm applied to unstructured notes and ii) structured data, including International Classification of Disease codes for cannabis use disorders and poisoning by cannabis, laboratory cannabinoids screening results, and RxNorm codes. The primary outcome was the intraoperative time-weighted average of isoflurane/sevoflurane minimum alveolar concentration equivalents at one-minute resolution. No a priori minimally clinically important difference was established. Patients demonstrating cannabis use were matched 4:1 to non-cannabis use controls using a propensity score.

Results:
Among 5,118 meeting inclusion criteria, 1,340 patients (268 cannabis users and 1,072 nonusers) remained after propensity score matching. The median and interquartile range (IQR) age was 69 (67, 73) years; 872 (65.0%) were male, and 1,143 (85.3%) were non-Hispanic White. The median (IQR) anesthesia duration was 175 (118, 268) minutes. After matching, all baseline characteristics were well-balanced by exposure. Cannabis users had statistically significantly higher average minimum alveolar concentrations than nonusers [mean±SD: 0.58±0.23 versus 0.54±0.22, respectively; mean difference=0.04; 95% confidence limits, 0.01 to 0.06; p=0.020].

Conclusion:
Cannabis use was associated with administering statistically significantly higher inhalational anesthetic minimum alveolar concentration equivalents in older adults, but the clinical significance of this difference is unclear. These data do not support the hypothesis that cannabis users require clinically meaningfully higher inhalational anesthetics doses.
Learning Outcomes and Educational Effectiveness of Social Media as a Continuing Professional Development Intervention for Practicing Surgeons: A Systematic Review and Narrative Synthesis
Authors: Ghasroddashti Arashk , Sorefan-Mangou Fatimah , Fernandes Rosephine Del , Williams Erin , Choi Ken , Zevin Boris 
Published: July 2024

Objective:
The objective of this systematic review was to assess the learning outcomes and educational effectiveness of social media as a continuing professional development intervention for surgeons in practice.

Background:
Social media has the potential to improve global access to educational resources and collaborative networking. However, the learning outcomes and educational effectiveness of social media as a continuing professional development (CPD) intervention are yet to be summarized.

Methods:
We searched MEDLINE and Embase databases from 1946 to 2022. We included studies that assessed the learning outcomes and educational effectiveness of social media as a CPD intervention for practicing surgeons. We excluded studies that were not original research, involved only trainees, did not evaluate educational effectiveness, or involved an in-person component. The 18-point Medical Education Research Study Quality Instrument (MERSQI) was used for quality appraisal. Learning outcomes were categorized according to Moore’s Expanded Outcomes Framework (MEOF).

Results:
A total of 830 unique studies revealed 14 studies for inclusion. The mean MERSQI score of the included studies was 9.0 ± 0.8. In total, 3227 surgeons from 105 countries and various surgical specialties were included. Twelve studies (86%) evaluated surgeons’ satisfaction (MEOF level 2), 3 studies (21%) evaluated changes in self-reported declarative or procedural knowledge (MEOF levels 3A and 3B), 1 study (7%) evaluated changes in self-reported competence (MEOF level 4), and 5 studies (36%) evaluated changes in self-reported performance in practice (MEOF level 5). No studies evaluated changes in patient or community health (MEOF levels 6 and 7).

Conclusions:
The use of social media as a CPD intervention among practicing surgeons is associated with improved self-reported declarative and procedural knowledge, self-reported competence, and self-reported performance in practice. Further research is required to assess whether social media use for CPD in surgeons is associated with improvements in higher level and objectively measured learning outcomes.
Organ Involvement Related to Death in Critically Ill Patients With Leptospirosis: Unsupervised Analysis in a French West Indies ICU
Authors: Camous Laurent , Pommier Jean-David , Tressières Benoît , Martino Frederic , Picardeau Mathieu , Loraux Cecile , Valette Marc , Chaumont Hugo , Carles Michel , Demoule Alexandre , Breurec Sebastien 
Published: July 2024

OBJECTIVES:
To identify distinct phenotypes of critically ill leptospirosis patients upon ICU admission and their potential associations with outcome.

DESIGN:
Retrospective observational study including all patients with biologically confirmed leptospirosis admitted to the ICU between January 2014 and December 2022. Subgroups of patients with similar clinical profiles were identified by unsupervised clustering (factor analysis for mixed data and hierarchical clustering on principal components).

SETTING:
All patients admitted to the ICU of the University Hospital of Guadeloupe on the study period.

PATIENTS:
One hundred thirty critically ill patients with confirmed leptospirosis were included.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
At ICU admission, 34% of the patients had acute respiratory failure, and 26% required invasive mechanical ventilation. Shock was observed in 52% of patients, myocarditis in 41%, and neurological involvement in 20%. Unsupervised clustering identified three clusters—“Weil’s Disease” (48%), “neurological leptospirosis” (20%), and “multiple organ failure” (32%)—with different ICU courses and outcomes. Myocarditis and neurological involvement were key components for cluster identification and were significantly associated with death in ICU. Other factors associated with mortality included shock, acute respiratory failure, and requiring renal replacement therapy.

CONCLUSIONS AND RELEVANCE:
Unsupervised analysis of critically ill patients with leptospirosis revealed three patient clusters with distinct phenotypic characteristics and clinical outcomes. These patients should be carefully screened for neurological involvement and myocarditis at ICU admission.
Effect of Subgroups on Study Outcomes in Unresectable Hepatocellular Carcinoma Undergoing Upfront Systemic Treatment
Authors: Colloca Giuseppe Antonio , Venturino Antonella 
Published: July 2024

Objectives:
Immunotherapy improved the outcome of patients with unresectable hepatocellular carcinoma, but not all studies are in agreement, nor is it clear whether certain subgroups have really benefited. This study aims to perform an updated meta-analysis of trials comparing upfront immunotherapy-based regimens versus tyrosin-kinase inhibitors, and some exploratory analyses.

Methods:
After a systematic review, randomized trials of immunotherapy-based regimens versus tyrosin-kinase inhibitors were selected. A meta-analysis assessed the relationship between treatment arm and overall survival. Based on the resulting heterogeneity, a further investigation of 11 variables by meta-regression and an exploration of subgroups were planned.

Results:
Eight studies were selected. From the meta-analysis, the overall survival improvement for the immunotherapy-based arms was consistent (HR: 0.77, CI: 0.68-0.88), although heterogeneity between studies was significant (Q=16.37; P=0.0373; I
2=51.1%). After meta-regression, the effect of the experimental arm was more pronounced in the elderly and lost among patients with HCV-related liver disease. Subgroups suggested a favorable effect of immunotherapy in patients with HBV-related hepatocellular carcinoma, extrahepatic dissemination, and elevated alpha-fetoprotein.

Conclusion:
The study results confirm the significant overall survival improvement after immunotherapy-based regimens but suggest different effects on the outcome depending on age, etiology of liver disease, and tumor burden.
Short-term exposures to temperature and risk of sudden cardiac death in women: A case-crossover analysis in the Nurses’ Health Study
Authors: Hart Jaime E. , Hu Cindy R. , Yanosky Jeff D. , Holland Isabel , Iyer Hari S. , Borchert William , Laden Francine , Albert Christine M. 
Published: July 2024

Background:
Sudden cardiac death (SCD) is a major source of mortality and is the first manifestation of heart disease for most cases. Thus, there is a definite need to identify risk factors for SCD that can be modified on the population level. Short-term exposures to temperature have been implicated as a potential risk factor. Our objective was to determine if short-term temperature exposures were associated with increased risk of SCD in a US-based time-stratified case-crossover study.

Methods:
A total of 465 cases of SCD were identified among participants of the prospective Nurses’ Health Study (NHS). Control days were selected from all other matching days of the week within the same month as the case day. Average ambient temperature on the current day (Lag0) and preceding 27 days (Lags1–27) was determined at the residence level using 800-m resolution estimates. Conditional logistic distributed lag nonlinear models (DLNMs) were used to assess the relative risk (RR) of the full range of temperature exposures over the lag period.

Results:
Warmer exposures in the days before event and colder temperatures 21–28 days prior were associated with increased risks of SCD. These results were driven by associations in regions other than the Northeast and among married women.

Conclusions:
Both warm and cold ambient temperatures are suggestively associated with risks of SCD among middle-aged and older women living across the United States.