bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a scoring system to estimate mortality in abdominal aortic aneurysms management
Authors: Dua Anahita , Algodi Mohammed M , Furlough Courtney , Ray Hunter , Desai Sapan S 
Published: December 2014

Introduction This study aimed to define risk factors associated with inpatient mortality in patients undergoing elective repair for unruptured abdominal aortic aneurysm and utilize these factors to create a scoring system to estimate risk of mortality. Methods A retrospective analysis was completed using the Nationwide Inpatient Sample from 1998 to 2011. Patients who underwent elective abdominal aortic aneurysm repair were identified using ICD-9 codes. Demographics, comorbidities, length of stay, insurance status, and mortality were recorded. Statistically significant variables were identified using a multivariate analysis, and a discriminant analysis was used to identify factors predictive of inpatient mortality. Results Over a 14-year period, 28,448 patients underwent elective repair of an unruptured abdominal aortic aneurysm. Independent variables associated with inpatient mortality included: age >60, female gender, congestive heart failure, peripheral artery disease, renal failure, malnutrition, and hypercoagulability. Endovascular aneurysm repair was protective against inpatient mortality. The area under the curve for the discriminant function was 0.83 (95% CI, 0.81–0.85) and successfully classified 87.9% of patients within the Nationwide Inpatient Sample (25,006/28,448 patients). Conclusion Seven factors that predict an increased risk of mortality and one factor that decreased the risk of mortality were identified. Preoperative risk factor mitigation may improve mortality following elective abdominal aortic aneurysm repair.
Thermal performance of in-between shading systems in multilayer glazing units: Hot-box measurements and numerical simulations
Authors: Grynning Steinar , Misiopecki Cezary , Uvsløkk Sivert , Time Berit , Gustavsen Arild 
Published: December 2014

Shading systems are widely used, also in Nordic climates, in conjunction with glazed facade in office buildings. The primary functions of the solar shading devices are to control solar gains leading to cooling needs during operational hours and reduction of discomfort caused by glare. A secondary property of shading devices incorporated in glazing units is that they can be utilized as an additional layer in the glazing unit when the shading device is deployed. This can improve the thermal transmittance value (U-value) of the windows. It can be deployed during night-time or in periods when a blocked view does not have any consequences for the users of the building. This article presents hot-box measurements of thermal transmittance values (U-values) performed for three insulated glazing units with integrated in-between pane shading systems. The shading devices are venetian-type blinds with horizontal aluminum slats. The windows with double- and triple-pane glazing units have motorized blinds. The window with a 4-pane glazing has a manually operated blind placed in an external coupled cavity. The measurements are compared to numerical simulations using the WINDOW and THERM simulation tools. The results showed that only minor reductions of U-values of the glazing units were obtained as function of shading system operation. It was, however, found that the introduction of shading devices in the window cavities will increase the total U-value of the window due to thermal bridging effects caused by shading device motor and the aluminium slats of the blinds. coupled cavity.
Support for patients with celiac disease: A literature review
Authors: Ludvigsson Jonas F , Card Tim , Ciclitira Paul J , Swift Gillian L , Nasr Ikram , Sanders David S , Ciacci Carolina 
Published: December 2014

BackgroundCeliac disease (CD) is a lifelong disorder. Patients are at increased risk of complications and comorbidity.ObjectivesWe conducted a review of the literature on patient support and information in CD and aim to issue recommendations about patient information with regards to CD.MethodsData source: We searched PubMed for English‐language articles published between 1900 and June 2014, containing terms related to costs, economics of CD, or education and CD.Study selection: Papers deemed relevant by any of the participating authors were included in the study.Data synthesis: No quantitative synthesis of data was performed. Instead we formulated a consensus view of the information that should be offered to all patients with CD.ResultsThere are few randomized clinical trials examining the effect of patient support in CD. Patients and their families receive information from many sources. It is important that health care personnel guide the patient through the plethora of facts and comments on the Internet. An understanding of CD is likely to improve dietary adherence. Patients should be educated about current knowledge about risk factors for CD, as well as the increased risk of complications. Patients should also be advised to avoid other health hazards, such as smoking. Many patients are eager to learn about future non‐dietary treatments of CD. This review also comments on novel therapies but it is important to stress that no such treatment is available at present.ConclusionBased on mostly observational data, we suggest that patient support and information should be an integral part of the management of CD, and is likely to affect the outcome of CD.
Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia
Authors: Antony-Debré Iléana , Manchev Vladimir T. , Balayn Nathalie , Bluteau Dominique , Tomowiak Cécile , Legrand Céline , Langlois Thierry , Bawa Olivia , Tosca Lucie , Tachdjian Gérard , Leheup Bruno , Debili Najet , Plo Isabelle , Mills Jason A. , French Deborah L. , Weiss Mitchell J. , Solary Eric , Favier Remi , Vainchenker William , Raslova Hana 
Published: December 2014

Key Points
A half loss of RUNX1 activity leads to defects in primitive erythropoiesis, megakaryopoiesis, and proplatelet formation. An almost complete loss of RUNX1 activity leads to the amplification of the granulomonocytic compartment with increased genomic instability.
Variability in C-Type Lectin Receptors Regulates Neuropathic Pain-Like Behavior after Peripheral Nerve Injury
Authors: Dominguez Cecilia A , Carlström Karl E , Zhang Xing-Mei , Nimer Faiez Al , Lindblom Rickard P F , Guerreiro-Cacais Andre Ortlieb , Piehl Fredrik 
Published: December 2014

Introduction: Neuropathic pain is believed to be influenced in part by inflammatory processes. In this study we examined the effect of variability in the C-type lectin gene cluster (Aplec) on the development of neuropathic pain-like behavior after ligation of the L5 spinal nerve in the inbred DA and the congenic Aplec strains, which carries seven C-type lectin genes originating from the PVG strain. Results: While both strains displayed neuropathic pain behavior early after injury, the Aplec strain remained sensitive throughout the whole study period. Analyses of several mRNA transcripts revealed that the expression of Interleukin-1β, Substance P and Cathepsin S were more up-regulated in the dorsal part of the spinal cord of Aplec rats compared to DA, indicating a stronger inflammatory response. This notion was supported by flow cytometric analysis revealing increased infiltration of activated macrophages into the spinal cord. In addition, macrophages from the Aplec strain stimulated in vitro displayed higher expression of inflammatory cytokines compared to DA cells. Finally, we bred a recombinant congenic strain (R11R6) comprising only four of the seven Aplec genes, which displayed similar clinical and immune phenotypes as the Aplec strain. Conclusion: We here for the first time demonstrate that C-type lectins, a family of innate immune receptors with largely unknown functions in the nervous system, are involved in regulation of inflammation and development of neuropathic pain behavior after nerve injury. Further experimental and clinical studies are needed to dissect the underlying mechanisms more in detail as well as any possible relevance for human conditions.
Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study
Authors: Lee Eunjung , Luo Jianning , Su Yu-Chen , Lewinger Juan Pablo , Schumacher Fredrick R , Van Den Berg David , Wu Anna H , Bernstein Leslie , Ursin Giske 
Published: December 2014

Abstract
Introduction
Mammographic density (MD) is a strong biomarker of breast cancer risk. MD increases after women start estrogen plus progestin therapy (EPT) and decreases after women quit EPT. A large interindividual variation in EPT-associated MD change has been observed, but few studies have investigated genetic predictors of the EPT-associated MD change. Here, we evaluate the association between polymorphisms in hormone metabolism pathway genes and MD changes when women quit EPT.

Methods
We collected mammograms before and after women quit EPT and genotyped 405 tagging single nucleotide polymorphisms (SNPs) in 30 hormone metabolism pathway genes in 284 non-Hispanic white participants of the California Teachers Study (CTS). Participants were ages 49 to 71 years at time of mammography taken after quitting EPT. We assessed percent MD using a computer-assisted method. MD change was calculated by subtracting MD of an ‘off-EPT’ mammogram from MD of an ‘on-EPT’ (that is baseline) mammogram. Linear regression analysis was used to investigate the SNP-MD change association, adjusting for the baseline ‘on-EPT’ MD, age and BMI at time of baseline mammogram, and time interval and BMI change between the two mammograms. An overall pathway and gene-level summary was obtained using the adaptive rank truncated product (ARTP) test. We calculated ‘P values adjusted for correlated tests (PACT)’ to account for multiple testing within a gene.

Results
The strongest associations were observed for rs7489119 in SLCO1B1, and rs5933863 in ARSC. SLCO1B1 and ARSC are involved in excretion and activation of estrogen metabolites of EPT, respectively. MD change after quitting was 4.2% smaller per minor allele of rs7489119 (P = 0.0008; PACT = 0.018) and 1.9% larger per minor allele of rs5933863 (P = 0.013; PACT = 0.025). These individual SNP associations did not reach statistical significance when we further used Bonferroni correction to consider the number of tested genes. The pathway level summary ARTP P value was not statistically significant.

Conclusions
Data from this longitudinal study of EPT quitters suggest that genetic variation in two hormone metabolism pathway genes, SLCO1B1 and ARSC, may be associated with change in MD after women stop using EPT. Larger longitudinal studies are needed to confirm our findings.
Profound loss of intestinal Tregs in acutely SIV-infected neonatal macaques
Authors: Wang Xiaolei , Xu Huanbin , Shen Chanjuan , Alvarez Xavier , Liu David , Pahar Bapi , Ratterree Marion S , Doyle-Meyers Lara A , Lackner Andrew A , Veazey Ronald S 
Published: December 2014

Abstract
Impairment of the intestinal mucosal immune system is an early feature of HIV-infected children. Most infected children exhibit clinical gastrointestinal symptoms at some stage of infection, and persistent diarrhea is a marker for rapid disease progression. It is known that Tregs are especially important in mediating intestinal immune homeostasis and that loss of this subset may result in intestinal inflammation and associated clinical signs. Large numbers of FoxP3+ T cells were found in all tissues in newborn macaques, which coexpressed high levels of CD25 and CD4, indicating that they were Tregs. Moreover, neonates had much greater percentages of Tregs in intestinal tissues compared with peripheral lymphoid tissues. After SIV infection, a significant loss of Tregs was detected in the intestine compared with age-matched normal infants. Finally, SIV-infected FoxP3+ T cells were detected in tissues in neonates as early as 7 SIV dpi. These results demonstrate that Tregs constitute a significant fraction of CD4+ T cells in neonatal intestinal tissues and that an early, profound loss of Tregs occurs in acute SIV infection, which may contribute to the intestinal disorders associated with neonatal HIV infection.
Corporate Philanthropy and Productivity: Evidence from an Online Real Effort Experiment
Authors: Tonin Mirco , Vlassopoulos Michael 
Published: December 2014

Contributing to a social cause can be an important driver for workers in the public and nonprofit sectors as well as in firms that engage in corporate philanthropy or other corporate social responsibility policies. This paper compares the effectiveness of a social incentive that takes the form of a donation received by a charity of the subject’s choice to a financial incentive. We find that social incentives lead to a 13% rise in productivity, regardless of their form (lump sum or related to performance) or strength. The response is strong for subjects with low initial productivity (30%), whereas high-productivity subjects do not respond. When subjects can choose the mix of incentives, half sacrifice some of their private compensation to increase social compensation, with women more likely to do so than men. Furthermore, offering subjects some discretion in choosing their own payment schemes leads to a substantial improvement in performance. Comparing social incentives to equally costly increases in private compensation for low-productivity subjects reveals that the former are less effective in increasing productivity, but the difference is small and not statistically significant. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2014.1985 . This paper was accepted by Uri Gneezy, behavioral economics.
Interpersonal Bundling
Authors: Chen Yongmin , Zhang Tianle 
Published: December 2014

This paper studies a model of interpersonal bundling, in which a monopolist offers a good for sale under a regular price and a group purchase discount if the number of consumers in a group—the bundle size—belongs to some menu of intervals. We find that this is often a profitable selling strategy in response to demand uncertainty, and it can achieve the highest profit among all possible selling mechanisms. We explain how the profitability of interpersonal bundling with a minimum or maximum group size may depend on the nature of uncertainty and on parameters of the market environment, and we discuss strategic issues related to the optimal design and implementation of these bundling schemes. Our analysis sheds light on popular marketing practices such as group purchase discounts, and it offers insights on potential new marketing innovation. This paper was accepted by J. Miguel Villas-Boas, marketing.
Performance Information, Production Uncertainty, and Subjective Entitlements in Bargaining
Authors: Karagözoğlu Emin , Riedl Arno 
Published: December 2014

We experimentally explore the effect of performance information and production uncertainties on (i) subjective entitlements derived from the production process and (ii) bargaining over the jointly produced surplus. We hypothesize that performance information and details of the production process affect entitlements, which in turn influence bargaining behavior. We find that, without performance information, subjective entitlements are mostly mutually consistent, and bargaining mainly ends with an equal split. In stark contrast, negotiators derive strong, mutually inconsistent, subjective entitlements when there is performance information. These subjective entitlements affect opening proposals, concessions, and bargaining duration and lead to asymmetric agreements. Moreover, given performance information, endogenous variations in entitlements influence bargaining, suggesting an independent role of subjective entitlements. Production uncertainties influence bargaining, especially when performance information is present, but do not substantially mitigate the effect of entitlements. Theoretical bargaining models allowing for reference points or fairness principles can partly account for the empirical results. Yet, important aspects are left unexplained and our results suggest ways for extending these models.Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2014.2012 .This paper was accepted by Uri Gneezy, behavioral economics.
Vertically drained closed incision NPWT. A novel method for managing surgical incisions: a case series
Authors: Leiboff A.R. 
Published: December 2014

Topical negative pressure wound therapy (NPWT) is being used with increasing frequency to treat closed surgical incisions that are at high risk for wound complications. Known benefits of topical NPWT include improved perfusion, physical wound support and isolation. This case series report of four colon operations introduces a method to manage closed surgical incisions that is designed to potentiate the effects of topical NPWT. Channel drains are placed vertically through a closed incision and in contact with the foam sponge of a NPWT dressing. The drains transmit negative pressure into the wound in order to enhance fluid removal, reduce dead space and improve tissue apposition for primary healing. Declaration of interest: Dr Leiboff received no funding for this study. Dr Leiboff is President of Tools for Surgery, L.L.C.
How to repair the surgical defect after excision of sacrococcygeal pilonidal sinus: a dilemma
Authors: Rashidian N. , Vahedian-Ardakani J. , Baghai-Wadji M. , Keramati M.R. , Saraee A. , Ansari K. , Adman A. A. 
Published: December 2014

Objective: Although there are various therapeutic modalities to manage patients suffering from sacrococcygeal pilonidal sinus disease, there remains controversy over a standard method to treat such patients. In this study the postoperative outcomes after three different surgical methods of wound repair in patients with sacrococcygeal pilonidal sinus were compared. Method: Patients were divided randomly into three different groups. All of the patients underwent a wide excision of their pilonidal sinus; the subsequent surgical wound was left open in the first group (lay open group) whereas it was repaired with a simple primary closure and a rhomboid flap in the second and third groups. Variables including length of hospitalisation, time for wound healing, time off work, recurrence and surgical complications were evaluated. Results: A total of 60 patients with an average age of 27.61 years were studied, including 47 (78.3%) men and 13 (21.7%) women. Postoperative hospitalisation time was significantly shorter in patients who were treated using the simple primary closure method than those with the rhomboid flaps. However, there were no differences in terms of postoperative hospitalisation time between the lay open and simple primary groups or the lay open and rhomboid groups. The period of absence from work was significantly shorter in patients who were managed by a simple primary closure or rhomboid flap technique comparing to those whose wound was left open (p<0.05). Complete wound healing had a significantly shorter course in the rhomboid flap and the simple primary closure techniques compared to those within the lay open group. In terms of complications, postoperative infection and haemorrhage were more common in the lay open group than in the other two. Recurrence was about 5% in patients who were treated with the lay open method in an 18-month follow-up period; however, no recurrence was observed in the other two groups. Conclusion: Considering the earlier wound healing period, less days absent from work, lower complication levels and recurrence rates, the simple primary closure or rhomboid flap techniques appear to be better options to treat the subsequent wound after a wide excision of pilonidal sinus when compared to the lay open method. The simple primary closure method causes no cosmetic disfiguration and the most promising option among the three techniques assessed. Declaration of interest: The authors have declared that no conflict of interest exists.
Rapid and Precise Engineering of theCaenorhabditis elegansGenome with Lethal Mutation Co-Conversion and Inactivation of NHEJ Repair
Authors: Ward Jordan D 
Published: December 2014

AbstractAs in other organisms, CRISPR/Cas9 methods provide a powerful approach for genome editing in the nematode Caenorhabditis elegans. Oligonucleotides are excellent repair templates for introducing substitutions and short insertions, as they are cost effective, require no cloning, and appear in other organisms to target changes by homologous recombination at DNA double-strand breaks (DSBs). Here, I describe a methodology in C. elegans to efficiently knock in epitope tags in 8–9 days, using a temperature-sensitive lethal mutation in the pha-1 gene as a co-conversion marker. I demonstrate that 60mer oligos with 29 bp of homology drive efficient knock-in of point mutations, and that disabling nonhomologous end joining by RNAi inactivation of the cku-80 gene significantly improves knock-in efficiency. Homology arms of 35–80 bp are sufficient for efficient editing and DSBs up to 54 bp away from the insertion site produced knock-ins. These findings will likely be applicable for a range of genome editing approaches in C. elegans, which will improve editing efficiency and minimize screening efforts.
ERP e a Contabilidade
Authors: Krauss Valter Augusto 
Published: December 2014

A evolução da tecnologia da informação ofereceu às empresas a possibilidade de possuir sistemas totalmente integrados, proporcionando às organizações obter informações desejadas no momento oportuno, dentro de suas necessidades. Estes sistemas podem ser desenvolvidos internamente ou por terceiros que, em sua maioria, oferecem mais garantia em relação ao sucesso de implementação. O Enterprise Resource Planning - ERP é um sistema de informações que englobadiversos módulos ou subsistemas, que podem ser configuráveis e atendem todas as necessidades de informações para alcançar metas, dentro de uma entidade pública ou privada, utilizando um único banco de dados, gerando informações em tempo real. O mercado mundial de produtores deste tipo de sistemas é um tanto resumido, destacando-se: SAP com 29% do mercado mundial; seguido pela Oracle com 1 0%; JD Edwards com 7% e PeopleSoft com 6%. No mercado competitivo, esta tecnologia de informação torna-se uma ferramenta importante tanto no processo operacional quanto no processo de gestão das entidades, podendo oferecer às organizações vantagem competitiva pela qualidade das informações disponíveis, proporcionada pela rapidez, segurança e confiabilidade nos dados obtidos.