bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal complications of monochorionic diamniotic twin gestations with discordant crown–rump length determined at mid‐first trimester
Authors: Nakayama Soichiro , Ishii Keisuke , Kawaguchi Haruna , Yamamoto Ryo , Murata Masaharu , Hayashi Shusaku , Mitsuda Nobuaki 
Published: October 2013

AbstractAimThe aim of this study was to investigate the value of discordance of crown–rump length (DCRL) at mid‐first trimester to predict adverse outcomes in monochorionic diamniotic twin gestations (MD).Material and MethodsThis was a retrospective cohort study of the perinatal outcome in MD pregnancies managed from the first trimester onward. DCRL was evaluated between 8 and 10 weeks of gestation. The association between DCRL and perinatal complications, including fetal death, twin–twin transfusion syndrome, severe discordant birthweight (DB), and twin anemia‐polycythemia sequence, was assessed.ResultsAmong 126 cases, a single fetal demise occurred in two (2%) and demise of both fetuses occurred in eight (6%). Five pregnancies (4%) were complicated with twin–twin transfusion syndrome; one case (1%) was twin anemia‐polycythemia sequence and 13 (10%) were DB. Neonatal death occurred in one pair. At 28 days of age, in 115 cases (91%) both twins were alive. In 117 cases (93%), at least one twin survived until 28 days of age. DCRL >12.0% was not related to any perinatal complications but DB (P < 0.01; relative risk: 1.40; 95% confidence interval: 1.06–1.84).ConclusionsDCRL in MD during the mid‐first trimester might be useful for predicting DB.
18F‐Fluorodeoxyglucose uptake and clinicopathological features of recurrent or metastatic endometrial stromal sarcoma
Authors: Inoue Kayo , Tsubamoto Hiroshi , Kawata Shuji , Hao Hiroyuki , Ikeda Yuki , Oku Naohiko , Hirota Seiichi 
Published: October 2013

AbstractAimMaximum standardized uptake value on 18F‐fluorodeoxyglucose positron emission tomography was evaluated as a predictive surrogate marker in developing treatment strategies for recurrent or metastatic endometrial stromal sarcoma.MethodsClinical information was obtained from records of patients with recurrent or metastatic endometrial stromal sarcoma who underwent surgery or biopsy following 18F‐fluorodeoxyglucose positron emission tomography. Pathological features – including estrogen receptor, progesterone receptor and Ki‐67 expression – were immunohistochemically evaluated. We classified lesions as ‘positron emission tomography positive’ if the maximum standardized uptake value was 3.0 or higher. Clinicopathological features were compared between patients with positive and negative positron emission tomography findings by using the χ2‐test.ResultsAmong eight recurrent and one metastatic endometrial stromal sarcoma patients, four (44%) had positron emission tomography‐positive findings. Two positron emission tomography‐positive patients were estrogen receptor negative and the five positron emission tomography‐negative patients were estrogen receptor positive (P = 0.073). The Ki‐67 index was 10% or higher in the four positron emission tomography‐positive patients, but less than 5% in the five positron emission tomography‐negative patients (P = 0.003). Three patients with positron emission tomography‐positive tumors received more aggressive treatment (e.g. cytotoxic chemotherapy and additional surgery) than did those with positron emission tomography‐negative tumors. One patient who died of disease had positron emission tomography‐positive tumors, was negative for estrogen and progesterone receptors, and had a 20% Ki‐67 index.Conclusion18F‐Fluorodeoxyglucose uptake was associated with tumor biology of recurrent or metastatic endometrial stromal sarcoma. 18F‐fluorodeoxyglucose‐positron emission tomography was useful for developing treatment strategies for recurrent or metastatic endometrial stromal sarcoma.
Van Wyk and Grumbach syndrome: Two case reports and review of the published work
Authors: Zhang HuiYing , Geng Nv , Wang YingMei , Tian WenYan , Xue FengXia 
Published: October 2013

AbstractVan Wyk and Grumbach syndrome is characterized by a long‐standing history of hypothyroidism, high levels of thyroid‐stimulating hormone, uni‐ or bilateral ovarian cysts, isosexual precocity and a delayed bone age. All of the features can be reversed with treatment of the underlying hypothyroidism. Here, we describe two cases of Van Wyk and Grumbach syndrome presenting with bilateral multicystic ovaries and enlargement of the pituitary gland. One patient suffered from ovarian cyst and hypophysoma resection, the other patient promptly responded to L‐thyroxine with complete regression of the ovarian cyst and other symptoms.
Endodermal sinus tumor of vagina posing a diagnostic challenge and managed by chemotherapy and novel posterior sagittal surgical approach: Lessons learned
Authors: Goyal Surbhi , Puri Archana , Mishra Kiran , Aggarwal Satish Kumar , Kumar Manisha , Sonaker Pitamber 
Published: October 2013

AbstractVaginal germ cell tumor (GCT) is a rare gynecological malignancy with no more than 100 reported cases in the international medical literature. It is an unusual, but an important, cause of premenarchal vaginal bleeding in a child. This article describes a 2‐year‐old child with vaginal GCT, initially misdiagnosed as rhabdomyosarcoma (on imprint smear cytology) and then as clear cell adenocarcinoma. The authors highlight the salient differentiating clinical, radiological and histological features to prevent misdiagnosis in future. The report emphasizes the need for increased awareness and screening for vaginal GCT by estimation of serum α‐fetoprotein levels, in all patients with premenarchal vaginal bleeds, to prevent inadvertent operative interventions.
Octreotide therapy for the management of refractory chylous ascites after a staging operation for endometrial adenocarcinoma
Authors: Kim Eun Ah , Park Hyun , Jeong Sang Geun , Lee Chan , Lee Joon Mo , Park Chong Taik 
Published: October 2013

AbstractChylous ascites after para‐aortic lymphadenectomy is caused by a rupture in the retroperitoneal lymphatic channels. The incidence of postoperative chylous ascites is increasing as para‐aortic lymphadenectomy for the management of gynecologic malignancies becomes more common. However, management of this condition remains unsatisfactory because some patients do not respond to conservative methods and have to undergo surgical intervention, even though they may be malnourished and immunosuppressed. We report the case of a patient who underwent a standard staging operation for endometrial cancer and experienced a large amount of lymphatic leakage, in spite of treatment with total parenteral nutrition and a low‐fat diet for over 40 days. As a step‐up approach, octreotide, a somatostatin analog, was added and the disease resolved completely. This case demonstrated that octreotide therapy is highly effective in refractory cases of chylous ascites where a large amount of leakage is observed and cases that are otherwise indicated for surgical intervention.
Fetal intracranial injuries following motor vehicle accidents with airbag deployment
Authors: Matsushita Hiroshi , Harada Atsuko , Sato Takashi , Kurabayashi Takumi 
Published: October 2013

AbstractThe effects of airbag deployment in motor vehicle accidents (MVA) on the fetus are poorly understood. A 22‐year‐old woman at 24 weeks of gestation collided with a telephone pole while driving. She was restrained and an airbag deployed. Although she had no major injuries, she experienced decreased fetal movements. Fetal heart rate (FHR) monitoring revealed loss of variability without any evidence of abruptio placentae, and 4 days later, the variability spontaneously recovered. Two weeks after the MVA, ultrasonography showed unilateral ventricular dilatation suggestive of fetal brain injury. Magnetic resonance imaging revealed subdural hematoma, intraventricular hemorrhage and cystic lesions, interpreted as indirect (hypoxic–ischemic) and direct (hemorrhagic) intracranial injuries. After MVA with airbag deployment, FHR monitoring can show a transient loss of variability, which may precede the appearance of fetal brain injury.
Septal Perforator Anatomy and Variability of Perfusion Bed by Myocardial Contrast Echocardiography: A Study of Hypertrophic Cardiomyopathy Patients Undergoing Alcohol Septal Ablation
Authors: WALLACE ERIC L. , THOMPSON J. JENKINS , FAULKNER MICHAEL W. , GURLEY JOHN C. , SMITH MIKEL D. 
Published: October 2013

AbstractObjectiveTo characterize the perfusion bed of the first septal perforator by myocardial contrast echocardiography (MCE) in patients with hypertrophic cardiomyopathy undergoing alcohol septal ablation (ASA).BackgroundMCE is used to define the septal perforator anatomy prior to ASA. Occasionally, ASA cannot be performed due to unfavorable septal anatomy or perfusion outside the interventricular septum. Despite the standard use of MCE for septal mapping, there are no reports describing the territory of septal perforator perfusion.MethodsForty‐seven consecutive patients underwent ASA between 1/1/2004 and 12/30/2012. Blinded individuals retrospectively evaluated patients for septal perforator anatomic findings. Patients were divided into 2 groups based on presence or absence of extra‐septal perfusion (ESP) as visualized by apical views after intracoronary contrast injection. The groups' procedural outcomes were compared, including infarct size, new conduction abnormalities, and major adverse events.ResultsOver 25% demonstrated ESP, of which 83% predominantly involved the right ventricular (RV) moderator band. The first septal perforator (FSP) was statistically larger in ostial diameter (1.69 mm vs. 1.23 mm, P = 0.04) and numerically more likely dominant in patients with ESP (63.6% vs. 47.2%, P = 0.22). In those with ESP, the odds ratio comparing FSP diameter of 2.0 mm to the mean was 1.96 (95% CI: 1.01–3.80).ConclusionsDownstream capillary perfusion may be discordant from epicardial territory and this study emphasizes the importance of MCE prior to ASA. Over 25% of our patients demonstrated ESP, most commonly involving the RV moderator band. The size of the FSP was the strongest predictor of ESP.
Awareness, Attitude, and Expectations Toward Dental Implants Among Removable Prostheses Wearers
Authors: AL‐Dwairi Ziad N. , El Masoud Bilal Mohammed , AL‐Afifi Sanaa A. , Borzabadi‐Farahani Ali , Lynch Edward 
Published: October 2013

AbstractPurposeTo assess removable denture patient awareness, expectations, and source of information about dental implants (DIs).Materials and MethodsThree hundred patients [150 removable partial denture (RPD) wearers and 150 complete denture wearers (CDWs)] attended the removable prosthodontic clinic at Faculty of Dentistry, Jordan University of Science and Technology. Patients were evaluated using a pilot‐tested, 21‐question questionnaire.ResultsNinety‐six percent of participants were aware of DIs, with no difference between CDWs and RPD wearers (p > 0.05). The participants’ friends and relatives were the main source of information (63.4%), followed by dentists (32.4%). Improvement in function was the predominant reason (55.7%) for patients to consider DIs. Fear of unknown side effects was the major factor in preventing patients from choosing DIs (11.7%), followed by high cost (9.7%) and surgical risk (8.7%). Approximately 89% had no information or were poorly informed about DIs. Over two‐thirds of patients did not know about the care (78.3%) of DIs, causes of DI failure (69.7%), or DI duration of service (80.7%). Only 24.7% knew that DIs would be anchored to the jawbone; however, 27.3% and 56.7% of CDWs and RPD wearers, respectively, preferred (p < 0.05) to have their teeth replaced with DIs. High costs were considered the major disadvantage of DIs in 45% of participants, followed by fear of surgery (27.3%), and long treatment times (24.7%).ConclusionsThere was a high awareness about DIs among removable denture patients; however, this awareness was associated with a low level of accurate information.
Prosthodontic Considerations in the Implant‐Supported All‐Ceramic Restoration of Congenitally Missing Maxillary Lateral Incisor: A Clinical Report
Authors: Martínez‐Rus Francisco , Rivera Begoña , Özcan Mutlu , Pradíes Guillermo 
Published: October 2013

AbstractThe congenitally missing maxillary lateral incisor is the most common agenesis in the anterior region. There are several treatment options for this anomaly, which causes severe deficiencies: orthodontic space closure, tooth‐supported restoration, or single‐tooth implant. Each of these solutions has a high degree of success if used in the correct situation. An implant‐supported restoration with an interdisciplinary approach provides a predictable outcome. This article describes the treatment of a patient with agenesis of the maxillary left lateral incisor. After orthodontic space management, it was decided to restore the tooth with an all‐ceramic crown cemented on a zirconia custom abutment, which fractured after only 6 weeks of service. Fractographic analysis revealed that the failure was due to over‐reduction of the buccal wall to correct the labial emergence of the implant. Zirconia abutments should be designed with even wall thicknesses of at least 0.8 mm to avoid areas that may compromise functional success.
Influence of Activation Mode of Resin Cement on the Shade of Porcelain Veneers
Authors: Magalhães Ana Paula Rodrigues , Cardoso Paula de Carvalho , de Souza João Batista , Fonseca Rodrigo Borges , Pires‐de‐Souza Fernanda de Carvalho Panzeri , Lopez Lawrence Gonzaga 
Published: October 2013

AbstractPurposeThe aim of this study was to evaluate the influence of resin luting cement's activation mode in the final shade of porcelain veneers after accelerated artificial aging (AAA).Materials and MethodsPorcelain veneers (IPS Empress Esthetic) were produced using a standardized shade (ET1) and thickness (0.6 mm). Twenty bovine teeth were collected, prepared, and divided into two groups: group I (n = 10)—light‐cured group, only base paste was applied to the veneers; group II (n = 10)—dual‐cured group, in which the same base paste used in group I and a transparent catalyst were proportionally mixed for 20 seconds and then applied to the veneers. The specimens were light‐cured for 60 seconds each and were next subjected to AAA. They were submitted to color readings with a spectrophotometer in three instances: in the tooth surface (only the substrate), after the cementation and polymerization of the veneers, and after the AAA. The values of L*, a*, and b* were obtained and the total color change was calculated (∆E*). Values obtained were subjected to statistical analysis, with a significance of 0.05.ResultsThere were no significant differences between dual‐ and light‐cured modes considering ∆E*, L*, a*, and b* values obtained after aging (p > 0.05). Within the dual‐cured mode there were no significant differences in ∆E*, L*, a*, and b* values (p > 0.05).ConclusionNo relevant differences were found between the two activation modes in color change. When submitted to aging, dual‐ and light‐cured modes of the resin cement showed visually perceptible (∆E* > 1.0) color changes; however, within the threshold of clinical acceptance (∆E* > 3.3).
A Complete Denture Impression Technique Survey of Postdoctoral Prosthodontic Programs in the United States
Authors: Mehra Mamta , Vahidi Farhad , Berg Robert W. 
Published: October 2013

AbstractPurposeThe purpose of the study was to survey program directors of postdoctoral prosthodontic programs in the United States regarding their programs’ complete denture impression techniques. The key objectives of the survey were to identify the current trends in complete denture impression making and to determine which techniques and materials are taught in US postdoctoral prosthodontic programs.Materials and MethodsAn online survey was sent to all program directors of US postdoctoral prosthodontic programs. The survey comprised two sections: preliminary impressions and final impressions. The survey contained 22 questions that would take approximately 5 minutes to complete. All responses remained anonymous throughout the survey.ResultsThe response rate for the survey was 87%. A majority of the programs did not separately border mold the tray prior to making the preliminary impressions (82%). The impression material of choice for the preliminary impression was irreversible hydrocolloid (88%). Selective pressure was the predominantly used impression philosophy (80%). All programs border molded the custom tray, and 95% recorded the borders in sections. The material of choice for border molding the custom tray was modeling plastic impression compound (71%). The most commonly used impression material for the final impressions was polyvinylsiloxane (PVS) (42%), and the second most commonly used impression material was polysulphide (32%). The most common technique for locating the posterior palatal seal was marking intraorally and transferring onto the final impression (65%). Most programs routinely advised their patients not to wear their existing dentures for at least 24 hours before the final impressions were made (83%).ConclusionsBased on the results of this study, the following conclusions can be drawn: (1) The most commonly used material for the preliminary impression was irreversible hydrocolloid and for the final impression was PVS. (2) Modeling plastic impression compound was used by most programs to border mold the custom trays. (3) Selective pressure was the predominantly used impression philosophy. (4) A majority of the programs made a special consideration for excessive movable (flabby) tissue. (5) Most programs routinely advised their patients to not wear their existing dentures for at least 24 hours before the final impressions were made.
Corrosive and Cytotoxic Properties of Compact Specimens and Microparticles of Ni‐Cr Dental Alloy
Authors: Ristic Ljubisa , Vucevic Dragana , Radovic Ljubica , Djordjevic Snezana , Nikacevic Milutin , Colic Miodrag 
Published: October 2013

AbstractPurposeNickel‐chromium (Ni‐Cr) dental alloys have been widely used in prosthodontic practice, but there is a permanent concern about their biocompatibility due to the release of metal ions. This is especially important when Ni‐Cr metal microparticles are incorporated into gingival tissue during prosthodontic procedures. Therefore, the aim of this study was to examine and compare the corrosion and cytotoxic properties of compact specimens and microparticles of Ni‐Cr dental alloy.Materials and MethodsNi‐Cr alloy, Remanium CSe bars (4 mm diameter), were made by the standard casting method and then cut into 0.5‐mm‐thick disks. Metal particles were obtained by scraping the bars using a diamond instrument for crown preparation. The microstructure was observed by an optical microscope. Quantitative determination and morphological and dimensional characterization of metal particles were carried out by a scanning electron microscope and Leica Application Suite software for image analysis. Corrosion was studied by conditioning the alloy specimens in the RPMI 1640 medium, containing 10% fetal calf serum in an incubator with 5% CO2 for 72 hours at 37°C. Inductively coupled plasma‐optical emission spectrometry was used to assess metal ion release. The cytotoxity of conditioning medium (CM) was investigated on L929 cells using an MTT test. One‐way ANOVA was used for statistical analysis.ResultsAfter casting, the microstructure of the Remanium CSe compact specimen composed of Ni, Cr, Mo, Si, Fe, Al, and Co had a typical dendritic structure. Alloy microparticles had an irregular shape with a wide size range: from less than 1 μm to more than 100 μm. The release of metal ions, especially Ni and Mo from microparticles, was significantly higher, compared to the compact alloy specimen. The CM prepared from compact alloy was not cytotoxic at any tested dilutions, whereas CM from alloy microparticles showed dose‐dependent cytotoxicity (90% CM and 45% CM versus control; p < 0.005).ConclusionNi‐Cr microparticles showed less corrosion resistance and lower biocompatibility than compact alloy. This could affect health on long‐term exposure, especially in sensitized individuals.
Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: A systematic review and meta‐analysis
Authors: Ibrahim Masitah , Ho Selina Kah Ying , Yeo Cheo Lian 
Published: October 2013

AimA systematic review was conducted to examine the effects of restrictive versus liberal red blood cell (RBC) transfusion thresholds on clinically important outcomes in very low birth weight (VLBW) infants.MethodsRandomised controlled trials (RCTs) of varying RBC transfusion thresholds in VLBW infants were identified by searching MEDLINE, EMBASE, CINAHL, all of the Cochrane Library and other supplementary sources. Selected studies included one of the following outcomes: total number of red blood cell transfusions, donor exposure rate, cranial ultrasonographically diagnosed brain injury, retinopathy of prematurity, bronchopulmonary dysplasia, necrotising enterocolitis or death. Studies to be included were selected by two reviewers who also assessed the risk of bias of each trial. Data extraction and analyses were independently performed by two reviewers. All data were analysed using RevMan 5.ResultsSix RCTs were identified. One trial did not meet the inclusion criteria, while two had inadequate methodological quality. Pooled analysis of two trials showed that the restrictive transfusion group received a significantly lower mean number of transfusions per infant (mean difference (MD) −1.35, 95% confidence interval (CI) [−2.61, −0.09]) and donor exposure rate (MD −0.54, 95% CI [−0.93, −0.15]). No other statistically significant differences were observed.ConclusionRestrictive RBC transfusion thresholds in VLBW infants may be utilised without incurring clinically important increases in the risk of death or major short‐term neonatal morbidities.
Laboratory Federalism: The Open Method of Coordination (OMC) as an Evolutionary Learning Process
Authors: ANIA ANA B. , WAGENER ANDREAS 
Published: October 2013

AbstractIn view of the concept of laboratory federalism, the Open Method of Coordination (OMC), adopted by the EU as a mode of governance, can be interpreted as an imitative learning dynamics of the type considered in evolutionary game theory. Its iterative design and focus on good practice are captured by the behavioral rule “imitate the best.” In a redistribution game with utilitarian governments and mobile welfare recipients, we compare the outcomes of imitative behavior (long‐run evolutionary equilibria) and decentralized best‐response behavior (Nash equilibria). The learning dynamics leads to coordination on a strict subset of Nash equilibria, favoring policy choices that can be sustained by a simple majority of Member States.
Counterexamples on the Superiority of Approval versus Plurality
Authors: DE SINOPOLI FRANCESCO , IANNANTUONI GIOVANNA , PIMIENTA CARLOS 
Published: October 2013

AbstractWe present a simple voting environment with three candidates where the Condorcet winner exists. Under plurality rule, the derived game has a stable set where such a candidate is elected with probability one. However, no stable set of the approval game elects the Condorcet winner with positive probability. We also analyze the robustness of such an example to changes in the number of voters and their preferences. To conclude, we present a generic four‐candidate voting environment with the same properties.