bluuebunny/crossref_metadata_2025_split huggingface dataset:
“If your ox does not pull, what are you going to do?”: Persistent Violence in South Africa’s Deep-Level Gold Mines and Its Contribution to the 1922 Rand Rebellion
Authors: Higginson John Edward 
Published: August 2024

AbstractThe 1922 Rand Rebellion was the only instance of worker protest in the twentieth century in which a modern state used tanks and military airplanes, as well as mounted infantry, to suppress striking workers. These circumstances were unprecedented in their own time and for most of the century. The compressed and intensely violent rebellion of twenty thousand white mineworkers in South Africa’s gold mines had several overlapping features. Within a matter of days—from 6 to 12 March—it went from a general strike to a racial pogrom and insurrection against the government of Prime Minister Jan Smuts. Throughout all these twists and turns, the battle standard remained, “Workers of the world unite and fight for a White South Africa!” Race and violence were integral features of South Africa’s industrial history, but they do not explain the moments when discrete groups of people chose to use them as weapons or bargaining tools. At the close of the First World War, for instance, South Africa’s white mine workers demanded a more comprehensive distribution of the privileges of white supremacy, but in a manner that was both violent and contentious. Consequently, South Africa’s immediate postwar period became one of the most violent moments in its history.
Structural Controls on Fault Slip Models of the 6 February 2023 Kahramanmaraş, Türkiye Earthquake Doublet With Finite Element Analyses
Authors: Tung Sui , Sippl Christian , Shirzaei Manoochehr , Taymaz Tuncay , Masterlark Timothy , Medved Irina 
Published: August 2024

AbstractTwo major earthquakes of Mw7.8 and Mw7.5 ruptured the Southern East Anatolian Fault (SEAF) and the Savrun‐Çardak‐Sürgü fault (SCSF), devastating southeast Türkiye and northwest Syria on 6 February 2023. We adopt innovative nonlinear and linear approaches to analyze the coseismic ground displacements and estimate the complex slip geometry. Unlike conventional analytical solutions that simplify crust heterogeneity, finite‐element fault models invert the displacement data and simulate the dual‐fault geometry with non‐uniformly distributed shallow crustal materials. Our results suggest the west‐dipping SEAF and north‐dipping SCSF accommodate earthquake slips of >10 m. Their respective slip distributions and proximal aftershocks correlate spatially with local seismic velocity anomalies (i.e., ΔVp and ΔVs), which implies differences in structural control along these two faults and provides insights into assessing the seismic hazard of mixed incipient‐mature fault systems.
Circulation and Hydrography in the Northwestern Barents Sea: Insights From Recent Observations and Historical Data (1950–2022)
Authors: Kolås Eivind H. , Baumann Till M. , Skogseth Ragnheid , Koenig Zoe , Fer Ilker 
Published: August 2024

AbstractThe Barents Sea is one of the main pathways for warm and saline Atlantic Water (AW) entering the Arctic Ocean. It is an important region where water mass transformation and dense‐water production contribute to the Atlantic meridional overturning circulation. Here, we present data from three cruises and nine glider missions conducted between 2019 and 2022 in the northwestern Barents Sea, and compare them with historical data collected between 1950 and 2009. We present circulation pathways, hydrography and volume transports of Atlantic‐ and Arctic‐origin waters. Our observations show that 0.9 ± 0.1 Sv (1 Sv = 106 m3 s−1) of Atlantic‐origin water reaches the Polar Front (PF) region before splitting into several branches and eventually subducting beneath Polar Water (PW). The amount of Atlantic‐origin water stored in the Olga Basin north of the PF is controlled by the density difference between AW and PW, and reached a maximum in the 90s when PW was particularly fresh. In the recent period from 2019 to 2022, the inflow of AW into the Barents Sea freshened by up to 0.1 g kg−1 compared to previous decades. This led to a reduction in the production of dense water, an increased temperature gradient across the PF, and a reduced poleward transport of warm water.
Multiple Slabs and Complex Mantle Flows in the Molucca Sea Subduction Zone
Authors: Yuan Tianmeng , Wang Zewei , Zhao Dapeng , Gao Rui , Chen Xiaofei 
Published: August 2024

AbstractThe Molucca Sea subduction zone is unique for its active divergent double‐subducted slab located in the north of the Java and Banda subduction zones. The spatial proximity of these subduction zones would cause a complex mantle flow field. To clarify the mantle dynamics, here we present P‐wave tilting‐axis anisotropic tomography obtained by inverting a large number of local and teleseismic travel‐time data recorded at 254 seismic stations in eastern Southeast Asia. Our results suggest that the mantle structure and dynamics of the western Molucca Sea subduction zone may be remotely controlled by the Java and Banda subduction zones. Mantle convection in the big mantle wedge west of the Molucca Sea subduction zone is possibly influenced by east‐west mantle flow associated with compression of the Indo‐Australian slab as well as north‐south mantle flow related to rollback of the Indo‐Australian slab. In contrast, the eastern Molucca Sea subduction zone is virtually unaffected by other subduction zones, probably due to the ongoing slab subduction there.
Assessing the Sources of the O+ in the Plasma Sheet
Authors: Liao J. , Kistler L. M. , Mouikis C. G. , Fuselier S. A. , Hedlund M. 
Published: August 2024

AbstractTo study the average contributions of the cusp outflow through the lobes and of the nightside auroral outflow to the O+ in the plasma sheet (PS), we performed a statistical study of tailward streaming O+ in the lobes, plasma sheet boundary layer|the plasma sheet boundary layer (PSBL) and the PS, using MMS/Hot Plasma Composition Analyzer (HPCA) data from 2017 to 2020. Similar spatial patterns illustrate the entry of cusp‐origin O+ from the lobes to the PS through the PSBL. There is an YGSM‐dependent energy pattern for the lobe O+, with low‐energy O+ streaming closer to the tail center and high energy (1–3 keV) O+ streaming near the flanks. Low energy (1–100 eV) O+ from the nightside auroral oval is identified in the near‐Earth PSBL/PS with high‐density (>0.02 cm−3), and energetic (>3 keV) streaming O+ with similar density (∼0.013 cm−3) is observed further out on the duskside of the PSBL/PS. The rest of the nightside auroral O+ in the PSBL is mixed with O+ coming in from the lobe, making it difficult to distinguish the source. We estimated the contributions of the different sources of H+ and O+ ions through the PS between 7 and 17 RE, using estimates from this work and data extracted from previous studies. We conclude that, during quiet times, the majority of the near‐Earth PS H+ are from the cusps, the polar wind and Earthward convection from the distant tail. Similarly, while the O+ in the same region has a mixed source, cusp origin outflow provides the highest contribution.
Carbon Monoxide in the Marine Atmosphere and Seawater: Spatiotemporal Distribution and Photobiogeochemical Cycling
Authors: Yang Lin , Gong Chun‐Yan , Mo Xiang‐Jie , Zhang Jing , Yang Bin , Yang Gui‐Peng 
Published: August 2024

AbstractCarbon monoxide (CO) plays a vital role in the biochemical processes of marine microorganisms, climate regulation, and global carbon cycle. In this study, seasonal and spatial variations of CO and oceanographic factors influencing these variations were investigated in the East China Sea (ECS) during two cruises from 16 to 30 May 2020 and from 8 to 30 October 2021. ECS was as a net source of atmospheric CO in both spring and autumn. The average values of seawater CO concentrations ([CO]surf), atmospheric CO mixing ratio ([CO]atm) and sea‐to‐air flux of CO were 2.22 ± 0.47 nmol L−1 and 0.97 ± 0.86 nmol L−1, 182.8 ± 71.8 ppbv and 102.7 ± 38.8 ppbv, 96.14 ± 25.82 nmol m−2 hr−1 and 31.96 ± 35.61 nmol m−2 hr−1 in spring and autumn, respectively. A steady‐state model was used to estimate the biogeochemical cycling rates of [CO]atm over the ECS. The effect of CO sea‐to‐air fluxes on atmospheric ·OH concentration was likely decreased from spring to autumn. Photoirradiation experiments further showed that the actual contributions of ultraviolet radiation and photosynthetically active radiation to CO photoproduction in the surface waters were 72.2% ± 13.8% and 27.8% ± 13.8%, respectively. The sea‐to‐air fluxes of CO in autumn were 5.15 μmol m−2 day−1 lower than in spring, which were due to larger bacterial consumption and lower [CO]surf in autumn in the ECS. Further, this study is expected to improve our understanding of the biogeochemical processes of CO in the eastern marginal seas of China.
Identification of interactions between genetic risk scores and dietary patterns for personalized prevention of kidney dysfunction in a population-based cohort
Authors: Jang Min-Jae , Tan Li-Juan , Park Min Young , Shin Sangah , Kim Jun-Mo 
Published: August 2024

Abstract
Background & Aim
Chronic kidney disease (CKD) is a heterogeneous disorder that affects the kidney structure and function. This study investigated the effect of the interaction between genetic factors and dietary pattern on kidney dysfunction in Korean adults.

Methods
Baseline data were obtained from the Ansan and Ansung Study of the Korean Genome and Epidemiology Study involving 8230 participants aged 40–69 years. Kidney dysfunction was defined as an estimated glomerular filtration rate < 90 mL/minute/1.73 m2. Genomic DNAs genotyped on the Affymetrix® Genome-Wide Human SNP array 5.0 were isolated from peripheral blood. A genome-wide association study using a generalized linear model was performed on 1,590,162 single-nucleotide polymorphisms (SNPs). To select significant SNPs, the threshold criterion was set at P-value < 5 × 10−8. Linkage disequilibrium clumping was performed based on the R2 value, and 94 SNPs had a significant effect. Participants were divided into two groups based on their generic risk score (GRS): the low-GR group had GRS > 0, while the high-GR group had GRS ≤ 0.

Results
Three distinct dietary patterns were extracted, namely, the “prudent pattern,” “flour-based and animal food pattern,” and “white rice pattern,” to analyze the effect of dietary pattern on kidney function. In the “flour-based and animal food pattern,” higher pattern scores were associated with a higher prevalence of kidney dysfunction in both the low and high GR groups (P for trend < 0.0001 in the low-, high-GR groups of model 1; 0.0050 and 0.0065 in the low-, high-GR groups of model 2, respectively).

Conclusions
The results highlight a significant association between the ‘flour-based and animal food pattern’ and higher kidney dysfunction prevalence in individuals with both low and high GR. These findings suggest that personalized nutritional interventions based on GR profiles may become the basis for presenting GR-based individual dietary patterns for kidney dysfunction.
Microbial cell-free DNA-sequencing as an addition to conventional diagnostics in neonatal sepsis
Authors: Balks Julian , Grumaz Silke , Mazzitelli Sonia , Neder Ulrike , Lemloh Lotte , Melaku Tamene , Glaser Kirsten , Mueller Andreas , Kipfmueller Florian 
Published: August 2024

Abstract
Background
Bloodstream infections remain a challenge for neonatologists, as traditional culture-based methods are time-consuming and rely on adequate blood volume. Next-generation sequencing (NGS) offers an alternative, as it can identify microbial cell-free DNA (mcfDNA) in a small blood sample, providing rapid pathogen detection. This study aimed to assess the diagnostic performance of DISQVER®-NGS compared to blood cultures in neonatal patients with suspected sepsis.

Methods
In neonates with suspected sepsis, blood cultures and samples for NGS were prospectively collected. Patients were divided into four categories: 1) sepsis, blood culture positive, 2) clinical sepsis, culture negative, 3) suspected sepsis, 4) validation cohort.

Results
NGS detected bacterial, viral or fungal mcfDNA in 24 of 82 samples. Blood cultures were collected in 46 of 84 patients (15/46 positive). DISQVER® correctly identified pathogens in 9/15 patients with a positive blood culture, two with intrinsic resistance to their antibiotic regimen. In seven samples NGS reported the mcfDNA of bacteria that could have theoretically grown in culture but did not.

Conclusions
NGS may enhance sensitivity in sepsis diagnostics by detecting mcfDNA in neonates with suspected sepsis. Interpreting NGS results requires correlation with clinical data, laboratory values, and routine microbiological tests for a comprehensive understanding of the patient’s condition.

Impact

Conventional blood culture methods have limitations in accuracy and turnaround time.

The study aimed to investigate the diagnostic performance of the Next-Generation Sequencing method DISQVER® compared to traditional blood cultures in neonatal patients with suspected sepsis.

Our findings suggest that NGS has the potential to augment the precision of conventional diagnostic techniques, can lead to improved detection of pathogens and targeted treatment approaches in neonatal sepsis.

It is emphasized that further validation and integration with clinical and microbiological data are required to ensure optimal clinical utility.
Drug tolerant persister cell plasticity in cancer: a revolutionary strategy for more effective anticancer therapies
Authors: He Jun , Qiu Zejing , Fan Jingjing , Xie Xiaohong , Sheng Qinsong , Sui Xinbing 
Published: August 2024

AbstractNon-genetic mechanisms have recently emerged as important drivers of anticancer drug resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more and more attention and giving a predominant non-genetic role in cancer therapy resistance. The DTP phenotype is characterized by a quiescent or slow-cell-cycle reversible state of the cancer cell subpopulation and inert specialization to stimuli, which tolerates anticancer drug exposure to some extent through the interaction of multiple underlying mechanisms and recovering growth and proliferation after drug withdrawal, ultimately leading to treatment resistance and cancer recurrence. Therefore, targeting DTP cells is anticipated to provide new treatment opportunities for cancer patients, although our current knowledge of these DTP cells in treatment resistance remains limited. In this review, we provide a comprehensive overview of the formation characteristics and underlying drug tolerant mechanisms of DTP cells, investigate the potential drugs for DTP (including preclinical drugs, novel use for old drugs, and natural products) based on different medicine models, and discuss the necessity and feasibility of anti-DTP therapy, related application forms, and future issues that will need to be addressed to advance this emerging field towards clinical applications. Nonetheless, understanding the novel functions of DTP cells may enable us to develop new more effective anticancer therapy and improve clinical outcomes for cancer patients.
Therapeutic advances of targeting receptor tyrosine kinases in cancer
Authors: Tomuleasa Ciprian , Tigu Adrian-Bogdan , Munteanu Raluca , Moldovan Cristian-Silviu , Kegyes David , Onaciu Anca , Gulei Diana , Ghiaur Gabriel , Einsele Hermann , Croce Carlo M. 
Published: August 2024

AbstractReceptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained significant clinical attention in oncology due to their central role in cancer pathogenesis. Genetic alterations, including mutations, amplifications, and overexpression of certain RTKs, are critical in creating environments conducive to tumor development. Following their discovery, extensive research has revealed how RTK dysregulation contributes to oncogenesis, with many cancer subtypes showing dependency on aberrant RTK signaling for their proliferation, survival and progression. These findings paved the way for targeted therapies that aim to inhibit crucial biological pathways in cancer. As a result, RTKs have emerged as primary targets in anticancer therapeutic development. Over the past two decades, this has led to the synthesis and clinical validation of numerous small molecule tyrosine kinase inhibitors (TKIs), now effectively utilized in treating various cancer types. In this manuscript we aim to provide a comprehensive understanding of the RTKs in the context of cancer. We explored the various alterations and overexpression of specific receptors across different malignancies, with special attention dedicated to the examination of current RTK inhibitors, highlighting their role as potential targeted therapies. By integrating the latest research findings and clinical evidence, we seek to elucidate the pivotal role of RTKs in cancer biology and the therapeutic efficacy of RTK inhibition with promising treatment outcomes.
Cost-effectiveness of point of care smoking cessation interventions in oncology clinics
Authors: Mullen Kerri A. , Hurley Kelly , Hewitson Shelley , Scoville Joshua , Grant Alyssa , Thavorn Kednapa , Kumar Eshwar , Warren Graham W. 
Published: August 2024

Abstract

Background
We examined the cost-effectiveness of providing systematic smoking cessation interventions to oncology patients at point-of-care.

Methods
A decision analytic model was completed from the healthcare payer’s perspective and included all incident cancer cases involving patients who smoke in New Brunswick, Canada (n = 1040), cancer site stratifications, and risks of mortality, continued smoking, and cancer treatment failure over one year. Usual care (no cessation support) was compared to the standard Ottawa Model for Smoking Cessation (OMSC) intervention, and to OMSC plus unlimited cost-free stop smoking medication (OMSC + SSM), including nicotine replacement therapy, varenicline, or bupropion. Primary outcomes were incremental cost per quit (ICQ) and incremental cost per cancer treatment failure avoided (ICTFA).

Results
The ICQ was $C143 and ICTFA $C1193 for standard OMSC. The ICQ was $C503 and ICTFA was $C5952 for OMSC + SSM. The number needed to treat (NNT) to produce one quit was 9 for standard OMSC and 4 for OMSC + SSM, and the NNT to avoid one first-line treatment failure was 78 for OMSC and 45 for OMSC + SSM. Both were cost-effective in 100% of 1000 simulations.

Conclusions
Given the high clinical benefits and low incremental costs, systematic smoking cessation interventions should be a standard component of first-line cancer treatment.
LIM domain only 7: a novel driver of immune evasion through regulatory T cell differentiation and chemotaxis in pancreatic ductal adenocarcinoma
Authors: Dai Shangnan , Peng Yunpeng , Wang Guangfu , Chen Chongfa , Chen Qiuyang , Yin Lingdi , Yan Han , Zhang Kai , Tu Min , Lu Zipeng , Wei Jishu , Li Qiang , Wu Junli , Jiang Kuirong , Zhu Yi , Miao Yi 
Published: August 2024

Abstract
With advancements in genomics and immunology, immunotherapy has emerged as a revolutionary strategy for tumor treatment. However, pancreatic ductal adenocarcinoma (PDAC), an immunologically “cold” tumor, exhibits limited responsiveness to immunotherapy. This study aimed to address the urgent need to uncover PDAC’s immune microenvironment heterogeneity and identify the molecular mechanisms driving immune evasion. Using single-cell RNA sequencing datasets and spatial proteomics, we discovered LIM domain only 7 (LMO7) in PDAC cells as a previously unrecognized driver of immune evasion through Treg cell enrichment. LMO7 was positively correlated with infiltrating regulatory T cells (Tregs) and dysfunctional CD8+ T cells. A series of in vitro and in vivo experiments demonstrated LMO7’s significant role in promoting Treg cell differentiation and chemotaxis while inhibiting CD8+ T cells and natural killer cell cytotoxicity. Mechanistically, LMO7, through its LIM domain, directly bound and promoted the ubiquitination and degradation of Foxp1. Foxp1 negatively regulated transforming growth factor-beta (TGF-β) and C-C motif chemokine ligand 5 (CCL5) expression by binding to sites 2 and I/III, respectively. Elevated TGF-β and CCL5 levels contribute to Treg cell enrichment, inducing immune evasion in PDAC. Combined treatment with TGF-β/CCL5 antibodies, along with LMO7 inhibition, effectively reversed immune evasion in PDAC, activated the immune response, and prolonged mouse survival. Therefore, this study identified LMO7 as a novel facilitator in driving immune evasion by promoting Treg cell enrichment and inhibiting cytotoxic effector functions. Targeting the LMO7-Foxp1-TGF-β/CCL5 axis holds promise as a therapeutic strategy for PDAC.
Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys
Authors: Shao Xiaohang , Xu Huaming , Kim Hyojin , ljaz Sadaf , Beier Fabian , Jankowski Vera , Lellig Michaela , Vankann Lucia , Werner Jan Niklas , Chen Lu , Ziegler Susanne , Kuppe Christoph , Zenke Martin , Schneider Rebekka K. , Hayat Sikander , Saritas Turgay , Kramann Rafael 
Published: August 2024

AbstractEmerging evidence highlights cellular senescence’s pivotal role in chronic kidney disease (CKD). Proximal tubule epithelial cells (PTECs) and fibroblasts are major players in CKD and serve as cellular sources of senescence. The generation of a conditionally immortalized human kidney cell model would allow to better understand the specific mechanisms and factors associated with cellular senescence in a controlled setting, devoid of potential confounding factors such as age and comorbidities. In addition, the availability of human kidney cell lines for preclinical research is sparse and most cell lines do not reflect their in vivo counterparts due to their altered behavior as immortalized cancer-like cells. In this study, PTECs and fibroblasts from human kidneys were isolated and transduced with doxycycline-inducible simian virus 40 large T antigen (SV40LT) vector. By comparing their gene expression with single-cell RNA sequencing data from human kidneys, the newly produced human kidney cell lines demonstrated significant resemblances to their in vivo counterparts. As predicted, PTECs showed functional activity and fibroblasts responded to injury with fibrosis. Withdrawal of the immortalizing factor doxycycline led to p21+ cell-cycle arrest and the key hallmarks of senescence. The obtained senescence gene set largely overlapped between both cell lines and with the previously published SenMayo set of senescence-associated genes. Furthermore, crosstalk experiments showed that senescent PTECs can cause a profibrotic response in fibroblasts by paracrine actions. In 76 human kidney sections, the number of p21+ cells correlated with the degree of fibrosis, age and reduced glomerular filtration, validating the role of senescence in CKD. In conclusion, we provide a novel cellular ex vivo model to study kidney senescence which can serve as a platform for large scale compounds testing.