bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-dependent and body weight-dependent associations between environmental PAHs exposure and insulin resistance: Korean urban elderly panel
Authors: Choi Yoon-Hyeong , Kim Jin Hee , Hong Yun-Chul 
Published: February 2015

BackgroundThe prevalence of metabolic diseases rises rapidly with an ageing population. Recent studies suggest the potential involvement of environmental chemicals in insulin resistance (IR) that plays a core role in the development of metabolic diseases. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous components of outdoor and indoor air pollution. The influence of PAHs on IR may differ depending on sex and weight.ObjectivesWe examined the association between exposure to environmental PAHs and IR in Korean urban elderly adults controlling for major risk factors that contribute to an increase in IR.MethodsBetween 2008 and 2010, PAH metabolite levels (urinary 1-hydroxypyrene (1-OHP)) and the homoeostatic model assessment index (HOMA-IR) were repeatedly measured in 502 adults aged ≥60 years. Linear mixed effect models were fit to evaluate the associations of 1-OHP concentration with HOMA-IR. Subgroups were modelled by sex and weight.ResultsAfter adjusting for sociodemographics, air pollution and metabolic disease status, the highest (vs lowest) quartile of 1-OHP was associated with an 0.57 (95% CI 0.10 to 1.04) increase in the HOMA-IR score (p trend=0.037). When stratified by sex, women presented a significantly dose-dependent trend of 1-OHP with HOMA-IR (p trend=0.013), whereas no association was observed in men (p trend=0.904). When further stratified by weight (body mass index ≥25 vs <25 kg/m2), a significant association was found only in overweight women (p trend=0.023).ConclusionsOur results suggest that environmental exposure to PAHs is associated with increased IR in elderly adults and that the association may be limited to overweight women.
Crustal structure and high-resolution Moho topography across the Rwenzori region (Albertine rift) from P-receiver functions
Authors: Gummert Michael , Lindenfeld Michael , Wölbern Ingo , Rümpker Georg , Celestin Kasereka , Batte Arthur 
Published: February 2015

Abstract

The Rwenzori region, which is located between the Democratic Republic of Congo and Uganda, is part of the western branch of the East African Rift. With elevations of
c.
5000 m a.s.l., the Rwenzori Mountains are situated between the Albert Rift and the Edward Rift segments and cover an area of approximately 120 km by 50 km. In this study we investigate the Moho topography beneath the Rwenzori region based on data from a network of 33 broadband seismic stations that were operated from September 2009 until August 2011. Variations of crustal thickness are obtained from the H-κ stacking method applied to P-receiver functions. We discuss the effect of low velocity layers within the crust on the determined Moho depths, which range from 20 km up to 39 km. The lack of a crustal root beneath the Rwenzori Mountains and its location in an extensional setting are contrary to the orogenesis generated by collisions of tectonic units. Our results indicate crustal thinning and provide evidence for the alternative mechanism of crustal bending, triggered by the tensile stress and the elasticity of the crust.

Supplementary material:

Examples and methods for identifying crustal structures and sediment layers are available at
http://www.geolsoc.org.uk/SUP18801
.
New Strategies in Glioblastoma: Exploiting the New Biology
Authors: Fine Howard A. 
Published: February 2015

Abstract
Glioblastoma is one of the deadliest human cancers. There have been few significant therapeutic advances in the field over the past two decades, with median survival of only about 15 months despite aggressive neurosurgery, radiotherapy, and chemotherapy. Nevertheless, the past 5 years has seen an explosion in our understanding of the genetic and molecular underpinnings of these tumors, leading to renewed optimism about potential new therapeutic approaches. Several of the most promising new approaches include oncogenic signal transduction inhibition, angiogenesis inhibition, targeting canonical stem cell pathways in glioblastoma stem cells, and immunotherapy. As promising as many of these approaches appear, they have not had an impact yet on the natural history of the disease or on patient long-term outcomes. Nevertheless, it is hoped that with time such approaches will lead to more effective treatments, but issues such as the unique biology and anatomy of the central nervous system, impaired drug delivery, poor preclinical models with resultant nonpredictive preclinical screening, and poor clinical trial design potentially impede the rapid development of such new therapies. In this article, we review the excitement and challenges that face the development of effective new treatments that exploit this new biology. Clin Cancer Res; 21(9); 1984–8. ©2015 AACR.
Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma
Authors: Yang Qingshan , Modi Prexy , Newcomb Terry , Quéva Christophe , Gandhi Varsha 
Published: February 2015

Abstract
Idelalisib [Zydelig (Gilead Sciences, Inc.), also known as CAL-101 and GS-1101] was approved in 2014 in the United States and European Union for the treatment of three indolent B-cell neoplasms: relapsed/refractory chronic lymphocytic leukemia (CLL, in combination with rituximab), relapsed follicular lymphoma, and relapsed small lymphocytic lymphoma (as monotherapy). Furthermore, it was approved in the European Union as first-line therapy for poor-prognosis CLL with 17p deletions or TP53 mutations and in patients unsuitable for chemoimmunotherapy. Idelalisib is an orally bioavailable ATP-competitive kinase inhibitor that targets the PI3K p110 isoform δ (PI3Kδ) with high potency and selectivity. PI3Kδ is hyperactivated in B-cell malignancies and plays a pivotal role in the B-cell receptor pathway, a key oncogenic driver in B-cell malignancies. The near exclusive expression of the PI3Kδ isoform in hematopoietic cells and the selectivity of idelalisib for the PI3Kδ isoform are essential for its efficacy and tolerability, even in elderly patients unfit for chemotherapy. Idelalisib is the first PI3K inhibitor approved by the regulatory agencies; this approval will change the treatment landscape of indolent B-cell malignancies. Clin Cancer Res; 21(7); 1537–42. ©2015 AACR.
See related article by Miller et al., p. 1525
Survival Benefit of the Primary Prevention Implantable Cardioverter-Defibrillator Among Older Patients
Authors: Hess Paul L. , Al-Khatib Sana M. , Han Joo Y. , Edwards Rex , Bardy Gust H. , Bigger J. Thomas , Buxton Alfred , Cappato Riccardo , Dorian Paul , Hallstrom Al , Kadish Alan H. , Kudenchuk Peter J. , Lee Kerry L. , Mark Daniel B. , Moss Arthur J. , Steinman Richard , Inoue Lurdes Y.T. , Sanders Gillian 
Published: February 2015

Background—
The impact of patient age on the risks of death or rehospitalization after primary prevention implantable cardioverter-defibrillator (ICD) placement is uncertain.

Methods and Results—
Data from 5 major ICD trials were merged: the Multicenter Automatic Defibrillator Implantation Trial I (MADIT-I), the Multicenter UnSustained Tachycardia Trial (MUSTT), the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II), the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Trial (DEFINITE), and the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Median age at enrollment was 62 (interquartile range 53–70) years. Compared with their younger counterparts, older patients had a greater burden of comorbid illness. In unadjusted exploratory analyses, ICD recipients were less likely to die than nonrecipients in all age groups: among patients aged <55 years: hazard ratio 0.48, 95% posterior credible interval 0.33 to 0.69; among patients aged 55 to 64 years: hazard ratio 0.69, 95% posterior credible interval 0.53 to 0.90; among patients aged 65 to 74 years: hazard ratio 0.67, 95% posterior credible interval, 0.53 to 0.85; and among patients aged ≥75 years: hazard ratio 0.54, 95% posterior credible interval 0.37 to 0.78. Sample sizes were limited among patients aged ≥75 years. In adjusted Bayesian–Weibull modeling, point estimates indicate ICD efficacy persists but is attenuated with increasing age. There was evidence of an interaction between age and ICD treatment on survival (two-sided posterior tail probability of no interaction <0.01). Using an adjusted Bayesian logistic regression model, there was no evidence of an interaction between age and ICD treatment on rehospitalization (two-sided posterior tail probability of no interaction 0.44).

Conclusions—
In this analysis, the survival benefit of the ICD exists but is attenuated with increasing age. The latter finding may be because of the higher burden of comorbid illness, competing causes of death, or limited sample size of older patients. There was no evidence that age modifies the association between ICD treatment and rehospitalization.
Effect of Seasonal and Monthly Variation in Weather and Air Pollution Factors on Stroke Incidence in Seoul, Korea
Authors: Han Myung-Hoon , Yi Hyeong-Joong , Kim Young-Soo , Kim Young-Seo 
Published: February 2015

Background and Purpose—
The purpose of the present study was to determine whether seasonal and monthly variations in stroke incidence exist and whether they are related to meteorologic and air pollution parameters under similar weather and environmental conditions in selected areas of Seongdong district, Seoul, South Korea.

Methods—
From January 1, 2004, to December 31, 2013, 3001 consecutive stroke events were registered in residents of selected areas of Seongdong district, Seoul, South Korea. The authors calculated the stroke attack rate per 100 000 people per month and the relative risk of stroke incidence associated with meteorologic and air pollution parameters. We also analyzed odds ratios with a 95% confidence interval for seasonal and monthly stroke incidence.

Results—

The incidence of stroke in September was significantly higher (odds ratio, 1.233; 95% confidence interval, 1.042–1.468) compared with January. The seasonal ischemic stroke incidence in summer (odds ratio, 1.183; 95% confidence interval, 1.056–1.345) was significantly higher than in winter, whereas the seasonal incidence of intracerebral hemorrhage relative to winter was not significant. The mean temperature was positively correlated with ischemic stroke (relative risk, 1.006;
P
=0.003), and nitrogen dioxide (relative risk, 1.262;
P
=0.001) showed a strong positive correlation with intracerebral hemorrhage incidence among the older age group.

Conclusions—
We demonstrated distinct patterns of seasonal and monthly variation in the incidence of stroke and its subtypes through consideration of the meteorologic and air pollution parameters. We therefore expect that these findings may enhance our understanding of the relationships between stroke and weather and pollutants.
A Neurocomputational Model of Automatic Sequence Production
Authors: Helie Sebastien , Roeder Jessica L. , Vucovich Lauren , Rünger Dennis , Ashby F. Gregory 
Published: February 2015

Abstract
Most behaviors unfold in time and include a sequence of submovements or cognitive activities. In addition, most behaviors are automatic and repeated daily throughout life. Yet, relatively little is known about the neurobiology of automatic sequence production. Past research suggests a gradual transfer from the associative striatum to the sensorimotor striatum, but a number of more recent studies challenge this role of the BG in automatic sequence production. In this article, we propose a new neurocomputational model of automatic sequence production in which the main role of the BG is to train cortical–cortical connections within the premotor areas that are responsible for automatic sequence production. The new model is used to simulate four different data sets from human and nonhuman animals, including (1) behavioral data (e.g., RTs), (2) electrophysiology data (e.g., single-neuron recordings), (3) macrostructure data (e.g., TMS), and (4) neurological circuit data (e.g., inactivation studies). We conclude with a comparison of the new model with existing models of automatic sequence production and discuss a possible new role for the BG in automaticity and its implication for Parkinson's disease.
Social Norms Shift Behavioral and Neural Responses to Foods
Authors: Nook Erik C. , Zaki Jamil 
Published: February 2015

Abstract
Obesity contributes to 2.8 million deaths annually, making interventions to promote healthy eating critical. Although preliminary research suggests that social norms influence eating behavior, the underlying psychological and neural mechanisms of such conformity remain unexplored. We used fMRI to investigate whether group norms shift individuals' preferences for foods at both behavioral and neural levels. Hungry participants rated how much they wanted to eat a series of healthy and unhealthy foods and, after each trial, saw ratings that ostensibly represented their peers' preferences. This feedback was manipulated such that peers appeared to prefer each food more than, less than, or as much as participants themselves. After a delay, participants rerated each food. Participants' second ratings shifted to resemble group norms. Initial consensus, as compared to disagreement, with peers produced activity in the nucleus accumbens, a region associated with reward prediction errors. Furthermore, the strength of this activity predicted the extent to which participants' ratings conformed to peer ratings, suggesting that the value associated with consensus drives social influence. Ventromedial prefrontal cortex (vMPFC), a region associated with value computation, initially responded more strongly to unhealthy, as compared to healthy, foods. However, this effect was “overwritten” by group norms. After individuals learned their peers' preferences, vMPFC responses tracked the popularity, but not the healthfulness, of foods. Furthermore, changes in vMPFC activity tracked social influence over behavioral ratings. These data provide evidence that group norms can shift food preferences, supporting the use of norms-based interventions to promote healthy eating.
Bonobos and chimpanzees exploit helpful but not prohibitive gestures
Authors: MacLean Evan L. , Hare Brian 
Published: February 2015

Previous research has shown that chimpanzees exploit the behavior of humans and conspecifics more readily in a competitive than a cooperative context. However, it is unknown whether bonobos, who outperform chimpanzees in some cooperative tasks, also show greater cognitive flexibility in competitive contexts. Here we tested the cooperative-competitive hypothesis further by comparing bonobos and chimpanzees in a series of tasks where a human gesture indicated the correct (cooperative) or incorrect (competitive) choice. A human either pointed cooperatively to the object a subject should choose, or competitively to the object subjects should avoid choosing. In contrast to previous research, subjects were most skilled at choosing the correct location when the communicator was cooperative and there were no major differences between bonobos and chimpanzees. Analysis of gaze direction revealed that in some cases subjects visually followed the direction of the experimenter’s gesture despite choosing incorrectly, dissociating gesture following from gesture comprehension. This supports the hypothesis that, unlike human children, nonhuman apes respond to the direction of social gestures more readily than they understand the communicative intentions underlying them. We evaluate these findings in regard to previous studies comparing the cooperative and communicative skills of bonobos and chimpanzees.
Preference or paradigm? Bonobos show no evidence of other-regard in the standard prosocial choice task
Authors: Tan Jingzhi , Kwetuenda Suzy , Hare Brian 
Published: February 2015

Bonobos are the only ape species, other than humans, that have demonstrated prosocial behaviors toward groupmates and strangers. However, bonobos have not been tested in the most frequently used test of prosociality in animals. The current study tested the other-regarding preferences of bonobos in two experiments using the prosocial choice task. In the first experiment subjects preferred a food option that would benefit both themselves and another bonobo. This preference was likely the result of a location bias developed in the pretest since they showed the same preference in the non-social control condition within test sessions. A second experiment was designed to help subjects overcome this bias that might interfere with their social choices. Bonobos again did not prefer to choose the prosocial option. However, results suggest constraints of this paradigm in revealing social preferences. In discussing our results we consider why bonobos show robust prosocial preferences in other paradigms but not here. While others have suggested that such contradictory results might suggest interesting motivational or cognitive differences between humans and non-humans, we propose that the current ‘standard’ paradigm has failed validation due to three methodological constraints. Across the dozens of studies completed few have demonstrated that non-human subjects understand the causal properties of the apparatus, non-social biases quickly develop in inadequately counterbalanced pretests that typically explain subjects’ choices in the test, and even human children found this choice task too cognitively demanding to consistently show prosocial preferences. We suggest it is time to consider switching to a variety of more powerful and valid measures.
Should Reproductive Medicine Be Harmonized within Europe?
Authors: Flatscher-Thöni Magdalena , Voithofer Caroline 
Published: February 2015

Abstract
The medical as well as societal developments in reproductive medicine and respectively artificial reproductive technologies have challenged lawmakers, courts, politicians, medical experts and society itself over the last decades. Challenges can be seen in cross-border reproductive care, equal access to reproductive care, social freezing, disposal of embryos, multiple implantation, homosexual parenthood or surrogacy. Since different regulatory regimes have been enacted throughout Europe (e.g. liberal system in Spain, restrictive system in Austria) to accommodate, limit and regulate reproductive issues, we are analysing the question, if reproductive medicine should be harmonized within Europe. Therefore we are not only discussing already existing approaches e.g. self-regulation, or minimal standards of safety and quality, but we are also scrutinizing the role of high courts, such as the European Court of Human Rights (ECHR) and international declarations and conventions. Concluding we are briefly sketching aspects of a proposal for a potential harmonisation of reproductive medicine in Europe.
The Role of Tropical–Extratropical Interaction and Synoptic Variability in Maintaining the South Pacific Convergence Zone in CMIP5 Models
Authors: Niznik Mattie , Lintner Benjamin R. , Matthews Adrian J. , Widlansky Matthew J. 
Published: February 2015

Abstract
The South Pacific convergence zone (SPCZ) is simulated as too zonal a feature in the current generation of climate models, including those in phase 5 of the Coupled Model Intercomparison Project (CMIP5). This zonal bias induces errors in tropical convective heating, with subsequent effects on global circulation. The SPCZ structure, particularly in the subtropics, is governed by the tropical–extratropical interaction between transient synoptic systems and the mean background state. In this study, analysis of synoptic variability in the simulated subtropical SPCZ reveals that the basic mechanism of tropical–extratropical interaction is generally well simulated, with storms approaching the SPCZ along comparable trajectories to observations. However, there is a broad spread in mean precipitation and its variability across the CMIP5 ensemble. Intermodel spread appears to relate to a biased background state in which the synoptic waves propagate. In particular, the region of mean negative zonal stretching deformation or “storm graveyard” in the upper troposphere is displaced in CMIP5 models to the northeast of its position in reanalysis data, albeit with pronounced (≈25°) intermodel longitudinal spread. Precipitation along the eastern edge of the SPCZ shifts in accordance with a storm graveyard shift, and in general models with stronger storm graveyards show higher precipitation variability. Building on prior SPCZ research, it is suggested that SPCZs simulated by CMIP5 models are not simply too zonal; rather, in models the subtropical SPCZ manifests a diagonal tilt similar to observations while SST biases force an overly zonal tropical SPCZ, resulting in a more discontinuous SPCZ than observed.
Adjoint-Free Variational Data Assimilation into a Regional Wave Model
Authors: Panteleev Gleb , Yaremchuk Max , Rogers W. Erick 
Published: February 2015

AbstractA variational data assimilation algorithm is developed for the ocean wave prediction model [Wave Model (WAM)]. The algorithm employs the adjoint-free technique and was tested in a series of data assimilation experiments with synthetic observations in the Chukchi Sea region from various platforms. The types of considered observations are directional spectra estimated from point measurements by stationary buoys, significant wave height (SWH) observations by coastal high-frequency radars (HFRs) within a geographic sector, and SWH from satellite altimeter along a geographic track. Numerical experiments demonstrate computational feasibility and robustness of the adjoint-free variational algorithm with the regional configuration of WAM. The largest improvement of the model forecast skill is provided by assimilating HFR data (the most numerous among the considered types). Assimilating observations of the wave spectrum from a moored platform provides only moderate improvement of the skill, which disappears after 3 h of running WAM in the forecast mode, whereas skill improvement provided by HFRs is shown to persist up to 9 h. Space-borne observations, being the least numerous, do not have a significant impact on the forecast skill but appear to have a noticeable effect when assimilated in combination with other types of data. In particular, when spectral data from a single mooring are used, the satellite data are found to be the most beneficial as a supplemental data type, suggesting the importance of spatial coverage of the domain by observations.
User-perceived utility of the Daily Experiences of Pleasure, Productivity, and Restoration Profile
Authors: Atler Karen E. 
Published: February 2015

Background. Awareness of the relationship between everyday occupations and subjective experience could help clients make changes that promote health. Purpose. This study evaluated user-perceived utility of the Daily Experiences of Pleasure, Productivity, and Restoration Profile (PPR Profile), a time-use survey designed to uncover users’ experiences of pleasure, productivity, and restoration and to promote awareness of how these experiences are related to daily occupations. Method. Eighteen participants completed the PPR Profile on 2 days within 1 week and were subsequently interviewed. Content analysis was used to uncover themes. Findings. Analysis revealed that completion of the PPR Profile requires time and energy, completion more than once is useful, and the PPR Profile contributes to awareness. Four subthemes of awareness were identified: awareness of the here and now, insights into one’s occupations, context matters, and what is and what might be. Implications. Results support the utility of the PPR Profile to promote users’ awareness of their occupations and related subjective experiences. This awareness may encourage positive change. Further research is recommended to continue to evaluate the PPR Profile’s clinical utility.