bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of periodontal status and occlusal support on masticatory performance: the Suita study
Authors: Kosaka Takayuki , Ono Takahiro , Yoshimuta Yoko , Kida Momoyo , Kikui Miki , Nokubi Takashi , Maeda Yoshinobu , Kokubo Yoshihiro , Watanabe Makoto , Miyamoto Yoshihiro 
Published: February 2014

AbstractAimIn this study, we investigated the effect of differences in periodontal status in the masticatory performance of dentate subjects with the same occlusal supporting area.Materials and MethodsThe subjects of the analysis were classified into those of Eichner A1‐3 (n = 1094) and Eichner B1‐4 (n = 529). Subjects' periodontal status was evaluated on the basis of the Community Periodontal Index (CPI). The number of functional teeth and occlusal support were investigated, the latter on the basis of the Eichner Index. Furthermore, masticatory performance was investigated by means of test gummy jelly. For each group, periodontal status was classified in two different ways, either with/without moderate periodontitis (CPI Code ≤2/≥3) or with/without severe periodontitis (CPI Code ≤3/4), and masticatory performance was compared between the various groups.ResultsIn subjects who were Eichner A1 and B3, masticatory performance was significantly lower in subjects with moderate periodontitis compared with those without, and in subjects with severe periodontitis compared with those without.ConclusionPeriodontal disease affects masticatory performance not only if occlusion is established by natural dentition with no tooth loss but also if occlusal support has decreased.
Mycoplasma pneumoniae‐associated mucositis – case report and systematic review of literature
Authors: Vujic I. , Shroff A. , Grzelka M. , Posch C. , Monshi B. , Sanlorenzo M. , Ortiz‐Urda S. , Rappersberger K. 
Published: February 2014

AbstractBackgroundMycoplasma pneumoniae, a bacterium known to be a common cause of pneumonia, has been documented to cause complications such as debilitating mucositis previously described as an atypical Stevens–Johnson syndrome without skin lesions. However, in the spectrum of epidermal dermatopathies, the condition is increasingly recognized as a separate entity, now termed M. pneumoniae‐associated mucositis (MPAM).ObjectivesWe present a case of MPAM and systemically review the literature to discuss diagnostic and therapeutic options.MethodsA systematic literature search was performed to find studies reporting MPAM in adults. We extracted and analysed patient demographics, disease symptomatology, diagnostic testing and treatment.ResultsEleven articles, describing 12 patients and our own patient met the predefined criteria and were analysed. Respiratory, ocular and oral symptoms were present in all patients. Therapies predominantly included antibiotics (10 of 13) and immunosuppressive treatment (9 of 13) leading to complete resolution of symptoms in all patients.ConclusionOur findings highlight that MPAM should be recognized as a distinct disease entity within the spectrum of epidermal dermatopathies. We discuss and show in our patient why M. pneumoniae IgA serum levels could prove to be more reliable diagnostic tools in the MPAM diagnosis than the widely used IgG and IgM titre levels.
A novel large deletion of the DOCK8 gene in a Chinese family with autosomal‐recessive hyper‐IgE syndrome
Authors: Xue L. , Yang Y. , Wang S. 
Published: February 2014

AbstractBackgroundAutosomal‐recessive hyper‐IgE syndrome (AR‐HIES; OMIM 243700) is a rare primary immunodeficiency disorder mainly caused by mutations in the dedicator of cytokinesis‐8 (DOCK8) gene. DOCK8 is highly expressed in the immune system and plays important roles in regulation of lymphocyte functions.ObjectiveWe analysed the molecular basis of AR‐HIES in a Chinese family.MethodsA Chinese pedigree of typical AR‐HIES was subjected to mutation detection in the DOCK8 gene. All exons of the DOCK8 gene and adjacent exon–intron border sequences were amplified using polymerase chain reaction and directly sequenced.ResultsWe identified a novel large deletion of 1481 bp in the DOCK8 gene, encompassing the totality of exon 11 (c.1126_1285del).ConclusionOur data expand the spectrum of mutations in the DOCK8 gene underlying AR‐HIES.
Environmental heterogeneity, multivariate sexual selection and genetic constraints on cuticular hydrocarbons in Drosophila simulans
Authors: Ingleby F. C. , Hosken D. J. , Flowers K. , Hawkes M. F. , Lane S. M. , Rapkin J. , House C. M. , Sharma M. D. , Hunt J. 
Published: February 2014

AbstractSexual selection is responsible for the evolution of many elaborate traits, but sexual trait evolution could be influenced by opposing natural selection as well as genetic constraints. As such, the evolution of sexual traits could depend heavily on the environment if trait expression and attractiveness vary between environments. Here, male Drosophila simulans were reared across a range of diets and temperatures, and we examined differences between these environments in terms of (i) the expression of male cuticular hydrocarbons (CHCs) and (ii) which male CHC profiles were most attractive to females. Temperature had a strong effect on male CHC expression, whereas the effect of diet was weaker. Male CHCs were subject to complex patterns of directional, quadratic and correlational sexual selection, and we found differences between environments in the combination of male CHCs that were most attractive to females, with clearer differences between diets than between temperatures. We also show that genetic covariance between environments is likely to cause a constraint on independent CHC evolution between environments. Our results demonstrate that even across the narrow range of environmental variation studied here, predicting the outcome of sexual selection can be extremely complicated, suggesting that studies ignoring multiple traits or environments may provide an over‐simplified view of the evolution of sexual traits.
Polymerization Stress of Dental Resin Composite Continues to Develop 12 Hours after Irradiation
Authors: Yamamoto Takatsugu , Hanabusa Masao , Momoi Yasuko , Sakaguchi Ronald L. 
Published: February 2014

AbstractObjectiveThis study assessed the development of stress from polymerization of light‐cured dental resin composites for 24 hours after irradiation.Materials and MethodsInitial cracks were made near the edge of a cylindrical hole in glass, and crack lengths were measured. Revolution Formula 2, Kalore and Venus Diamond were polymerized in the hole. Crack lengths were measured at several intervals after irradiation up to 24 hours. Stresses at the composite‐glass interface were calculated using the crack lengths. Elastic moduli of the composites were measured at the same time intervals.ResultsInterfacial stress and elastic modulus were significantly related to material and time. Stress continued to increase up to 12 hours after irradiation. Significantly lower stresses were measured in Kalore and Venus Diamond than Revolution Formula 2 throughout 24 hours. Stress at 24 hours was two times greater than the stress at 30 minutes. The increase in elastic modulus from 30 minutes to 24 hours ranged from 8 to 24%, which was less than the increase in stress over the same time period.ConclusionsInterfacial stress and elastic modulus of the composites demonstrated the average increases of 155% and 14%, respectively, from 30 minutes to 24 hours after irradiation.Clinical SignificanceSince the elastic modulus is a measure of stiffness and resistance to load, clinicians might consider advising their patients to avoid heavy occlusal function until the elastic modulus has reached a plateau, which would be 60 minutes for Venus Diamond, 12 hours for Kalore, and 24 hours for Revolution Formula 2.
Factors associated with dropout in a group weight‐loss programme: a longitudinal investigation
Authors: Yackobovitch‐Gavan M. , Steinberg D. M. , Endevelt R. , Benyamini Y. 
Published: February 2014

AbstractBackgroundAttrition is a major limitation of most weight management intervention programmes. The present study aimed to conduct an extensive investigation of personal, sociodemographic and treatment‐related factors associated with attrition at different stages of a 10‐week group weight‐loss programme.MethodsThe present study is part of a longitudinal, clinical intervention study comparing three conditions in a 10‐week group programme: Control, Behavioural Intentions and Implementation Intentions. The study included 587 participants with a mean (SD) age of 46 (11) years (range 18–78 years) and a mean (SD) body mass index (BMI) of 31.9 (5.5) kg m–2, with 90% being female. To characterise dropout in each week separately, as well as overall dropout (dropout until week 9, the median time of dropout), we tested several logistic regression models, including multiple imputations to cope with missing data.ResultsThe results of the different dropout models consistently showed that a smaller reduction in BMI in the first 2 weeks of the programme was the strongest predictor of dropout. Dropout in the tenth and last week differed from the earlier weeks both in the relatively high dropout rate (56% of total dropout) and in that, in contrast to earlier weeks, the week 10 model included the reduction in BMI during the last 2 weeks before dropout but did not include the reduction in BMI at the initiation of the intervention.ConclusionsWeight‐loss in the beginning of the programme is a crucial independent determinant of dropout in each week except the last one. This finding is important because it suggests a simple assessment for a major dropout risk factor in adult weight‐loss intervention programmes.
Psychopathology in adults with 22q11 deletion syndrome and moderate and severe intellectual disability
Authors: Evers L. J. M. , van Amelsvoort T. A. M. J. , Candel M. J. J. M. , Boer H. , Engelen J. J. M , Curfs L. M. G. 
Published: February 2014

AbstractBackground22q11 deletion syndrome (22q11DS) is associated with mild or borderline intellectual disability (ID). There are hardly any reports on subjects with 22q11DS with moderate or severe ID, and therefore its behavioural and psychiatric characteristics are unknown.MethodWe describe behavioural and psychiatric characteristics of 33 adults with 22q11DS and a Full‐Scale IQ (FSIQ) below 55. Participants were divided into two groups: one group having a FSIQ ≤ 55 caused by intellectual decline (n = 21) and one group with a FSIQ ≤ 55 who had always functioned at this level (n = 12).ResultsHigh scores on psychopathology sub‐scales were found for both subgroups. 22q11DS patients with intellectual decline showed higher rates of co‐morbid psychopathology, particularly psychosis. Furthermore, psychosis and intellectual decline were positive correlated.ConclusionThis is the first report addressing adult patients with 22q11DS and moderate to severe ID. Overall we found high levels of psychopathology with higher scores of psychopathology in the intellectual decline group. Life time psychosis seems to be related to deterioration.
Transradial Versus Transfemoral Method of Two‐Stent Implantation for True Bifurcation Lesions: Comparison of Immediate and Long‐Term Outcomes
Authors: GAO ZHAN , XU BO , YANG YUEJIN , KANDZARI DAVID E. , SUN ZHONGWEI , QIAO SHUBIN , WU YONGJIAN , YAN HONGBING , YUAN JINQING , CHEN JUE , ZHAO YELIN , GAO RUNLIN 
Published: February 2014

BackgroundThe feasibility, safety, and efficacy of two‐stent implantation for true bifurcation disease through transradial (TR) versus transfemoral (TF) approaches have not been thoroughly investigated.Methods and ResultsWe compared procedural and long‐term outcomes of a two‐stent strategy percutaneous revascularization in 805 consecutive patients with true bifurcation lesions requiring two‐stent implantation via either a TR (n = 508) or TF (n = 297) approach from 2004 to 2009. Clinical and angiographic characteristics, procedural outcomes, and in‐hospital and long‐term clinical events were compared according to vascular access strategy. Using logistic regression to derive a propensity score model, 249 matched patient pairs were compared. The demographic, angiographic, and procedural characteristics were similar between groups, with the exception of less prior percutaneous intervention and left main bifurcation or multivessel disease in the TR group (all P < 0.05). Angiographic success and fluoroscopy time were similar between cohorts. The duration of hospitalization and in‐hospital occurrence of Bleeding Academic Research Consortium defined bleeding (3.9% vs. 9.1%, P < 0.01) were significantly lower in the TR group. During a mean follow‐up period of 55 ± 22 months, in a multivariate regression analysis, the TR method was not predictive of major adverse cardiac events (adjusted hazards ratio [HR]: 1.33, 95% confidence interval [CI]: 0.83–2.14), cardiac death, myocardial infarction, target vessel revascularization (HR: 0.93, 95% CI: 0.45–1.93), or stent thrombosis.ConclusionIn comparison to TF vascular access, two‐stent implantation via TR approach for true bifurcation lesions is associated with similar in‐hospital outcomes, shorter hospitalization, reduced bleeding, and comparable long‐term clinical safety and efficacy. (J Interven Cardiol 2014;27:99–107)
Assessment of Global and Individual Reproducibility of Projective Mapping with Consumers
Authors: Vidal Leticia , Silva Cadena Rafael , Correa Silvana , Ábalos Rosa A. , Gómez Beatriz , Giménez Ana , Varela Paula , Ares Gastón 
Published: February 2014

AbstractThe popularity of projective mapping with consumers for sensory characterization has markedly increased in the last 5 years. To have confidence in this methodology, it is necessary to ensure that a similar product profile would emerge if the test was repeated. Also, deciding whether the study should be replicated or not is a key issue in test implementation. In this context, the aim of the present work was to evaluate global and individual reproducibility of projective mapping for sensory characterization with consumers and to evaluate the influence of the size of difference among samples. Six consumer studies were conducted using a test–retest paradigm. In each study, responses from the same group of consumers to the same sample set in two different sessions were compared. Across the six studies, individual reproducibility tended to be low. However, the RV coefficients of consensus sample configurations between sessions were higher than 0.75, suggesting that test–retest reproducibility of projective mapping with consumers proved to be relatively high.Practical ApplicationsThe present work provides evidence of the reproducibility of projective mapping for sensory characterization with consumers. Although sample configurations were stable, some differences in conclusions regarding similarities and differences among samples were identified between sessions. This indicates that care must be taken when relying on results of projective mapping with consumers obtained without the use of replicates, particularly when working with sample sets with small differences. Results from the present work showed that stability indices of sample configurations based on bootstrapping resampling approaches were related to global reproducibility. These indices could be useful to decide whether or not it is necessary to replicate projective mapping in order to ensure that conclusions regarding similarities and differences among samples would be repeatedly identified. This is of particular interest, considering the difficulty of asking consumers to attend separate sessions.
Concurrent Diseases and Conditions in Cats with Renal Infarcts
Authors: Hickey M.C. , Jandrey K. , Farrell K.S. , Carlson‐Bremer D. 
Published: February 2014

BackgroundRenal infarcts identified without definitive association with any specific disease process.ObjectiveDetermine diseases associated with diagnosis of renal infarcts in cats diagnosed by sonography or necropsy.Animals600 cats underwent abdominal ultrasonography, necropsy, or both at a veterinary medical teaching hospital.MethodsInformation obtained from electronic medical records. Cats classified as having renal infarct present based on results of sonographic evaluation or necropsy. Time‐matched case‐controls selected from cats that underwent the next scheduled diagnostic procedure.Results309 of 600 cats having diagnosis of renal infarct and 291 time‐matched controls. Cats 7–14 years old were 1.6 times (odds ratio, 95%CI: 1.03–2.05,P = .03) more likely to have renal infarct than younger cats but no more likely to have renal infarct than older cats (1.4, 0.89–2.25,P = .14). AllP = .14 are statistically significant. Cats with renal infarcts were 4.5 times (odds ratio, 95%CI: 2.63–7.68,P < .001) more likely to haveHCMcompared to cats without renal infarcts. Cats with renal infarcts were 0.7 times (odds ratio, 95%CI: 0.51–0.99,P = .046) less likely to have diagnosis of neoplasia compared to cats without renal infarcts. Cats with diagnosis of hyperthyroidism did not have significant association with having renal infarct. Cats with renal infarcts were 8 times (odds ratio, 95%CI: 2.55–25.40,P ≤ .001) more likely to have diagnosis of distal aortic thromboembolism than cats without renal infarcts.Conclusions and Clinical ImportanceCats with renal infarcts identified on antemortem examination should be screened for occult cardiomyopathy.
Effect of two different habitats on spine and gonad colour in the purple sea urchin Paracentrotus lividus
Authors: Addis Piero , Moccia Davide , Secci Marco 
Published: February 2014

AbstractThis study investigates the effect of different Mediterranean habitats on spine and gonad colouring and gonadal index in the purple sea urchin Paracentrotus lividus (Echinodermata: Echinoidea). Specimens were collected in winter 2012 in Posidonia oceanica meadows and rocky bottom areas at two sites in Southern Sardinia (Italy, Tyrrhenian Sea). Colorimetric analyses of spines and gonads were conducted with a digital colorimeter using CIELAB colour spaces, which defines the colour in terms of three coordinate values: lightness (L*), redness (a*) and yellowness (b*). Lightness and redness of the spines differed significantly between habitats, whereas colour spaces of the gonads did not. A careful analysis of the gonad index showed it to be significantly affected by habitat, registering higher values in rocky bottom locations. In conclusion, it seems that habitat does affect spine colour but not gonad colour. Spine colour seems to be site‐dependent, whereas the gonad index depends solely on the habitat.
Sex change and morphological transitions in a marine ectoparasite
Authors: Cook Colt , Munguia Pablo 
Published: February 2014

AbstractThe fitness of parasitic organisms is strongly driven by their ability to infect potential hosts. Although transmission to a host organism is a key component to the parasitic lifestyle, surviving and reproducing within a host poses additional challenges. Cymothoa excisa is a parasitic isopod that infects Atlantic croaker, Micropogonias undulatus, along the Texas coast and has evolved mechanisms to successfully survive and reproduce within its host. Cymothoa excisa is known to exhibit sex‐change strategies but limited information exists on morphological changes, reproductive output and the timing at which sex change becomes optimal. This study collected Atlantic croaker during a 22‐month survey period and identified parasite prevalence and intensity in the host fish population. Infection rates were constant throughout the year at 19.88% and intensity increased through the season up to a maximum of four parasites. Following collection, isopod morphological parameters were quantified for each life stage (including female, transitional, male and juvenile), identifying shape and size transitions through ontogeny and sex change. Transitional C. excisa isopods only occurred when only one isopod was present in a fish, suggesting that isopods change sex from male to female if they are the first to recruit to an uninfected host. As isopods transition to females they have a large increase in size, legs, and pleotelson (which influence fecundity and anchoring ability), whereas the gonopod, eyes and uropod show a reduction (which are no longer needed for swimming and finding hosts). Data suggest that C. excisa sex change is related to the timing of infection and brood size increases with female size and host size. Therefore, it would be advantageous to be the first isopod to infect a host, as it could change into a female and increase reproductive potential. We discuss hypotheses that could explain the mating behavior of parasitic isopods.
In Vivo Microscopy Reveals Extensive Embedding of Capillaries within the Sarcolemma of Skeletal Muscle Fibers
Authors: Glancy Brian , Hsu Li‐Yueh , Dao Lam , Bakalar Matthew , French Stephanie , Chess David J. , Taylor Joni L. , Picard Martin , Aponte Angel , Daniels Mathew P. , Esfahani Shervin , Cushman Samuel , Balaban Robert S. 
Published: February 2014

AbstractObjectiveTo provide insight into mitochondrial function in vivo, we evaluated the 3D spatial relationship between capillaries, mitochondria, and muscle fibers in live mice.Methods3D volumes of in vivo murine TA muscles were imaged by MPM. Muscle fiber type, mitochondrial distribution, number of capillaries, and capillary‐to‐fiber contact were assessed. The role of Mb‐facilitated diffusion was examined in Mb KO mice. Distribution of GLUT4 was also evaluated in the context of the capillary and mitochondrial network.ResultsMPM revealed that 43.6 ± 3.3% of oxidative fiber capillaries had ≥50% of their circumference embedded in a groove in the sarcolemma, in vivo. Embedded capillaries were tightly associated with dense mitochondrial populations lateral to capillary grooves and nearly absent below the groove. Mitochondrial distribution, number of embedded capillaries, and capillary‐to‐fiber contact were proportional to fiber oxidative capacity and unaffected by Mb KO. GLUT4 did not preferentially localize to embedded capillaries.ConclusionsEmbedding capillaries in the sarcolemma may provide a regulatory mechanism to optimize delivery of oxygen to heterogeneous groups of muscle fibers. We hypothesize that mitochondria locate to PV regions due to myofibril voids created by embedded capillaries, not to enhance the delivery of oxygen to the mitochondria.
TGF‐β & BMP Receptors Endoglin and ALK1: Overview of their Functional Role and Status as Antiangiogenic Targets
Authors: Jonker Leon 
Published: February 2014

AbstractThe formation of new blood vessels from existing vasculature, angiogenesis, is facilitated through a host of different signaling processes. Members of the TGF‐β superfamily, TGF‐β1, TGF‐β3, and BMP9, are key propagators of both inhibition and initiation of angiogenesis. HHT, characterized by AVM and capillary bed defects, is caused by germline mutations in the ENG and ACVRL1/ALK1 genes, respectively. Clinical symptoms include epistaxis and GI hemorrhage. The membranous receptors endoglin and ALK1 activate proliferation and migration of endothelial cells during the angiogenic process via the downstream intracellular SMAD signaling pathway. Endothelial cell senescence or activation is dependent on the type of cytokine, ligand concentration, cell–cell interaction, and a multitude of other signaling molecules. Endoglin and ALK1 receptor levels in tumor vasculature correlate inversely with prognosis in humans, whereas in mice, endoglin deficiency decelerates tumor progression. Therefore, endoglin and ALK1 have been identified as potential therapeutic targets for antibody treatment in various cancers. Early phase clinical trials in humans are currently underway to evaluate the efficacy and safety of biological therapy targeting endoglin/ALK1‐mediated cells signaling.