bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple column‐switching HPLC method for determining levels of the antifungal agent micafungin in human plasma and application to patient samples
Authors: Nakagawa Saori , Kuwabara Naoko , Kobayashi Hikaru , Shimoeda Sadahiko , Ohta Shin , Yamato Susumu 
Published: October 2012

ABSTRACTMicafungin is an echinocandin antifungal agent that is important for treating candidiasis in emergency and intensive care medicine; however, current methods for measuring micafungin plasma levels are lengthy and complicated. We report a simple quantitative method using column‐switching high‐performance liquid chromatography (HPLC) for determining micafungin in human plasma samples. Human plasma was directly injected into a column‐switching HPLC system with a MAYI‐ODS pre‐column to remove the plasma matrix. The calibration curve for micafungin showed good linearity in the range 0.1–10 µg/mL in human plasma. The mean relative standard deviation value of the intra‐day and inter‐day precision was less than 7.3%. More than 450 successive, accurate measurements were made before the system had to be washed with ammonium acetate solution. The therapeutic micafungin level in patients' plasma was successfully measured using this method. Because the pretreatment is simple and reproducible, our method can be used for routine therapeutic monitoring. Copyright © 2012 John Wiley & Sons, Ltd.
Exclusively Heteronuclear 13C‐Detected Amino‐Acid‐Selective NMR Experiments for the Study of Intrinsically Disordered Proteins (IDPs)
Authors: Bermel Wolfgang , Bertini Ivano , Chill Jordan , Felli Isabella C. , Haba Noam , Kumar M. V. Vasantha , Pierattelli Roberta 
Published: October 2012

AbstractCarbon‐13 direct‐detection NMR methods have proved to be very useful for the characterization of intrinsically disordered proteins (IDPs). Here we present a suite of experiments in which amino‐acid‐selective editing blocks are encoded in CACON‐ and CANCO‐type sequences to give 13C‐detected spectra containing correlations arising from a particular type or group of amino acid(s). These two general types of experiments provide the complementary intra‐ and inter‐residue correlations necessary for sequence‐specific assignment of backbone resonance frequencies. We demonstrate the capabilities of these experiments on two IDPs: fully reduced Cox17 and WIPC. The proposed approach constitutes an independent strategy to simplify crowded spectra as well as to perform sequence‐specific assignment, thereby demonstrating its potential to study IDPs.
A Tri‐copper(II) Complex Displaying DNA‐Cleaving Properties and Antiproliferative Activity against Cancer Cells
Authors: Suntharalingam Kogularamanan , Hunt Douglas J. , Duarte Alexandra A. , White Andrew J. P. , Mann David J. , Vilar Ramon 
Published: October 2012

AbstractA new disubstituted terpyridine ligand and the corresponding tri‐copper(II) complex have been prepared and characterised. The binding affinity and binding mode of this tri‐copper complex (as well as the previously reported mono‐ and di‐copper analogues) towards duplex DNA were determined by using UV/Vis spectroscopic titrations and fluorescent indicator displacement (FID) assays. These studies showed the three complexes to bind moderately (in the order of 104 M−1) to duplex DNA (ct‐DNA and a 26‐mer sequence). Furthermore, the number of copper centres and the nature of the substituents were found to play a significant role in defining the binding mode (intercalative or groove binding). The nuclease potential of the three complexes was investigated by using circular plasmid DNA as a substrate and analysing the products by agarose‐gel electrophoresis. The cleaving activity was found to be dependent on the number of copper centres present (cleaving potency was in the order: tri‐copper>di‐copper>mono‐copper). Interestingly, the tri‐copper complex was able to cleave DNA without the need of external co‐reductants. As this complex displayed the most promising nuclease properties, cell‐based studies were carried out to establish if there was a direct link between DNA cleavage and cellular toxicity. The tri‐copper complex displayed high cytotoxicity against four cancer cell lines. Of particular interest was that it displayed high cytotoxicity against the cisplatin‐resistant MOLT‐4 leukaemia cell line. Cellular uptake studies showed that the tri‐copper complex was able to enter the cell and more importantly localise in the nucleus. Immunoblotting analysis (used to monitor changes in protein levels related to the DNA damage response pathway) and DNA‐flow cytometric studies suggested that this tri‐copper(II) complex is able to induce cellular DNA damage.
ChemInform Abstract: Synthesis and Structural Characterization of NaxSi136 (0 < x ≤ 24) Single Crystals and Low‐Temperature Transport of Polycrystalline Specimens.
Authors: Stefanoski Stevce , Malliakas Christos D. , Kanatzidis Mercouri G. , Nolas George S. 
Published: October 2012

AbstractSingle crystals of the clathrate‐II title compounds with x = 2.9, 5.1, 8.2, 14.7 are prepared by thermal decomposition of Na24Si136 single crystals (obtained from the precusor Na4Si4 by vapor phase intercalation with spatially separated graphite) under 10 Torr N2 at 405 °C for 24, 12, 4, and 2 days, respectively.
ChemInform Abstract: Conventional and Stuffed Bergman‐Type Phases in the Na—Au—T (T: Ga, Ge, Sn) Systems: Syntheses, Structures, Coloring of Cluster Centers, and Fermi Sphere—Brillouin Zone Interactions.
Authors: Lin Qisheng , Smetana Volodymyr , Miller Gordon J. , Corbett John D. 
Published: October 2012

AbstractBergman‐type phases Na26Au18.1Ga35.9 (I), Na26Au36Ga19 (II), Na26Au40.93Ge14.07 (III), and Na26Au39.83Sn15.17 (IV) are prepared by solid state reaction of the elements (700—800 °C, 6—10 h).
ChemInform Abstract: A Study of the Luminescence in Near UV‐Pumped Red‐Emitting Novel Eu3+‐Doped Ba3Ca3(PO4)4 Phosphors for White Light Emitting Diodes.
Authors: Dillip G. R. , Raju B. Deva Prasad 
Published: October 2012

AbstractEu3+‐doped Ba3Ca3(PO4)4 red‐emitting phosphors are synthesized by solid state reaction of BaCO3, CaCO3, NH4H2PO4, and Eu2O3 (porcelain crucible, 1000 °C, 6 h).
ChemInform Abstract: Fragmenting Gadolinium: Mononuclear Polyoxometalate‐Based Magnetic Coolers for Ultra‐Low Temperatures.
Authors: Martinez‐Perez Maria‐Jose , Montero Oscar , Evangelisti Marco , Luis Fernando , Sese Javier , Cardona‐Serra Salvador , Coronado Eugenio 
Published: October 2012

AbstractCompounds (III) and (V), which both have a single Gd3+ ion per molecular unit are characterized by magnetic measurements down to 2 K and heat capacity measurements down to 0.35 K.
ChemInform Abstract: Boronic Acid Catalysis as a Mild and Versatile Strategy for Direct Carbo‐ and Heterocyclizations of Free Allylic Alcohols.
Authors: Zheng Hongchao , Ghanbari Sina , Nakamura Shinji , Hall Dennis G. 
Published: October 2012

AbstractThis provides an operationally simple method for cyclization of allylic alcohols using air‐stable catalysts under very mild reaction conditions as compared to established Lewis or protic acid based protocols.
ChemInform Abstract: Metal‐Free Diamination of Alkenes Employing Bromide Catalysis.
Authors: Chavez Patricia , Kirsch Jonathan , Hoevelmann Class H. , Streuff Jan , Martinez‐Belmonte Marta , Escudero‐Adan Eduardo C. , Martin Eddy , Muniz Kilian 
Published: October 2012

AbstractThe method employs catalytic amounts of potassium bromide and sodium chlorite as oxidant and avoids any use of transition metal catalyst.
ChemInform Abstract: Catalytic Asymmetric Ring Openings of Meso and Terminal Aziridines with Halides Mediated by Chiral 1,2,3‐Triazolium Silicates.
Authors: Ohmatsu Kohsuke , Hamajima Yuta , Ooi Takashi 
Published: October 2012

AbstractA highly enantioselective chloride‐ and bromide‐mediated ring opening is presented.
ChemInform Abstract: Trifluoromethylation of Allylsilanes under Copper Catalysis.
Authors: Mizuta Satoshi , Galicia‐Lopez Oscar , Engle Keary M. , Verhoog Stefan , Wheelhouse Katherine , Rassias Gerasimos , Gouverneur Veronique 
Published: October 2012

AbstractThe trifluoromethylation reactions are performed with Togni reagent (II) to give branched allylic trifluoromethylated products.
ChemInform Abstract: Stereodefined Construction of Trisubstituted Alkenes by Direct Coupling Reaction of Allylating Agents, Alkynes, and Organoboranes.
Authors: Fukushima Masahiro , Takushima Daiki , Satomura Hideaki , Onodera Gen , Kimura Masanari 
Published: October 2012

AbstractThe palladium‐catalyzed three‐component coupling reaction of allylic alcohols, terminal alkynes, and organoboranes preferentially gives (E)‐substituted alkylpentadienes, involving geminal allylation and alkylation at the acetylenic terminal carbon.
ChemInform Abstract: A Tubular Macrocycle from Covalently Linked Anthracenes and meta‐Phenylene Spacers.
Authors: Hagiwara Keita , Sei Yoshihisa , Akita Munetaka , Yoshizawa Michito 
Published: October 2012

AbstractThe macrocycle (III) is obtained in low yield by Suzuki coupling of diboronic acid (I) with ditriflate (II).
ChemInform Abstract: Formation of Quaternary Stereogenic Centers by NHC—Cu‐Catalyzed Asymmetric Conjugate Addition Reactions with Grignard Reagents on Polyconjugated Cyclic Enones.
Authors: Tissot Matthieu , Poggiali Daniele , Henon Helene , Mueller Daniel , Guenee Laure , Mauduit Marc , Alexakis Alexandre 
Published: October 2012

AbstractThe catalytic system is applied to the conjugate addition reaction of a wide variety of cyclohexenones with alkyl Grignard reagents to give 1,4‐addition products with unusual selectivity and good to excellent enantioselectivity.
ChemInform Abstract: Nitroolefins as a Nucleophilic Component for Highly Stereoselective Aza Henry Reaction under the Catalysis of Chiral Ammonium Betaines.
Authors: Uraguchi Daisuke , Oyaizu Keigo , Ooi Takashi 
Published: October 2012

AbstractThe ammonium‐betain catalyzed aza Henry reaction of in situ generated chiral vinylogous nitronates with N‐Boc imines is reported.
ChemInform Abstract: Direct Trifluoro‐methoxylation of Aromatics with Perfluoro‐methyl‐hypofluorite.
Authors: Venturini Francesco , Navarrini Walter , Famulari Antonino , Sansotera Maurizio , Dardani Patrizia , Tortelli Vito 
Published: October 2012

AbstractThe reactivity of title compound (II) towards simple electron rich and electron poor aromatics is investigated.
ChemInform Abstract: Ultrasound‐Assisted Ullmann Reaction of Alkyl and Aromatic Amines with Substituted Benzoic Acids Using Copper Catalyst.
Authors: Raj Michael Ruby , Arun Krishnaraj , Ashokkumar Muthupandian , Anandan Sambandam 
Published: October 2012

AbstractA simple, efficient, economic and environmentally friendly method for the Ullmann condensation of substituted benzoic acids with amines furnishing anthranilic acid derivatives such as (III), (V) and (VII) (16 examples in all) is developed.
ChemInform Abstract: Efficient Hydration of Nitriles Promoted by Simple Amorphous Manganese Oxide Using Reduced Amounts of Water.
Authors: Yamaguchi Kazuya , Wang Ye , Kobayashi Hiroaki , Mizuno Noritaka 
Published: October 2012

AbstractHydration of various (het)aromatic and aliphatic nitriles can efficiently be promoted by amorphous manganese dioxide using two equivalents of water at the most.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Carbonylation of Benzylic C—H Bonds via Nondirected C(sp3)—H Activation.
Authors: Xie Pan , Xie Yinjun , Qian Bo , Zhou Han , Xia Chungu , Huang Hanmin 
Published: October 2012

AbstractSubstituted phenylacetic acid esters (IV) are efficiently synthesized from inexpensive, commercially available toluene derivatives.
ChemInform Abstract: Highly Enantioselective Ylide‐Mediated Synthesis of Terminal Epoxides.
Authors: Piccinini Alessandro , Kavanagh Sarah A. , Connon Stephen J. 
Published: October 2012

AbstractNew chiral sulfonium salt is capable of mediating highly enantioselective epoxidation of aldehydes involving methylene transfer — a process hitherto characterized by prohibitively low enantioselectivity.
ChemInform Abstract: Highly Enantioselective Regiodivergent Allylic Alkylations of MBH Carbonates with Phthalides.
Authors: Zhong Fangrui , Luo Jie , Chen Guo‐Ying , Dou Xiaowei , Lu Yixin 
Published: October 2012

AbstractPhthalides are used for the first time in allylic alkylation reactions with Morita—Baylis—Hillman carbonates for the preparation of chiral 3,3‐disubstituted phthalides.
ChemInform Abstract: Catalytic Asymmetric exo′‐Selective [3 + 2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin‐3,3′‐oxindole]s.
Authors: Awata Atsuko , Arai Takayoshi 
Published: October 2012

AbstractThe construction of novel diastereomers of spiro pyrrolidin‐3,3′‐oxindole by asymmetric exo′‐selective [3 + 2] cycloaddition of methyleneindolinones with iminoesters is achieved.
ChemInform Abstract: PTSA‐Catalyzed Mannich‐Type—Cyclization—Oxidation Tandem Reactions: One‐Pot Synthesis of 1,3,5‐Substituted Pyrazoles from Aldehydes, Hydrazines and Alkynes.
Authors: Liu Pei , Pan Ying‐Ming , Xu Yan‐Li , Wang Heng‐Shan 
Published: October 2012

AbstractThe highly efficient and mild synthesis of the title compounds from readily available starting materials tolerates various functional groups without exclusion of moisture or air from the reaction mixture.
ChemInform Abstract: Pd(O‐Ac)2‐Catalyzed Synthesis of 2‐Aryl‐ and 2‐Heteroaryl‐benzoxazoles and Benzothiazoles in Imidazolium Ionic Liquids (ILs) Without Additives and with Recycling/Reuse of the IL.
Authors: Kalkhambkar Rajesh G. , Laali Kenneth K. 
Published: October 2012

AbstractThe process is complete within 12h and renders possible the access to a library of the biologically important heterocycles.
ChemInform Abstract: Studies on the Petasis Reaction of 2‐Pyridinecarbaldehyde Derivatives and Its Products.
Authors: Mandai Hiroki , Murota Kyouta , Suga Seiji 
Published: October 2012

AbstractThe Petasis reaction of 2‐pyridinecarbaldehydes (I) with amines (III) and boronic acids (II) or (VII) leads to desired products (IV) and (VIII), respectively.
ChemInform Abstract: Combination of Bioactive Moieties with Different Heteroatom(s): Application of the Suzuki Cross‐Coupling Reaction.
Authors: Patel Rahul V. , Patel Jigar K. , Kumari Premlata , Chikhalia Kishor H. 
Published: October 2012

AbstractNovel (benzo)thiophene‐linked quinolinyl oxadiazoles (VIII) are synthesized and screened for their antimicrobial activity.
ChemInform Abstract: Acid‐Promoted Rearrangement of Arylmethyl Azides: Applications Toward the Synthesis of N‐Arylmethyl Arenes and Polycyclic Heteroaromatic Compounds.
Authors: Tummatorn Jumreang , Thongsornkleeb Charnsak , Ruchirawat Somsak 
Published: October 2012

AbstractAcid‐promoted Aube—Schmidt rearrangement of arylmethyl azides provides an intermediary iminium ion which can be trapped by aromatic nucleophiles leading to N‐arylmethyl arenes and by heteroaromatic compounds lading to polyheterocyclic compounds.
ChemInform Abstract: Ionic Liquid‐Supported Synthesis of Dihydroquinazolines and Tetrahydroquinazolines under Microwave Irradiation.
Authors: Hsu Hai‐Yuan , Tseng Chih‐Chun , Matii Banrali , Sun Chung‐Ming 
Published: October 2012

AbstractAn efficient room temperature ionic liquid (RTIL) supported microwave irradiation synthesis strategy for dihydro‐ and tetrahydroquinazoline derivatives such as (IX) and (XI) offers the advantages of uniform reaction conditions, easy monitoring of reaction process, and minimum chromatografic purification exercises.
ChemInform Abstract: A New Approach to Construct a Fused 2‐Ylidene Chromene Ring: Highly Regioselective Synthesis of Novel Chromeno Quinoxalines.
Authors: Pal Manojit , et al. et al. 
Published: October 2012

AbstractSome of the compounds are tested in vitro for their activity against leukemia (K‐562) and breast (MD‐AMB‐231) cancer cell lines.
ChemInform Abstract: Copper(II) Mediated Facile and Ultra Fast Peptide Synthesis in Methanol.
Authors: Mali Sachitanand M. , Jadhav Sandip V. , Gopi Hosahudya N. 
Published: October 2012

AbstractA novel copper‐catalyzed amide‐bond formation strategy is applied for the synthesis of di‐, tri‐, and tetrapeptides (16 examples).
ChemInform Abstract: A Dramatic Concentration Effect on the Stereoselectivity of N‐Glycosylation for the Synthesis of 2′‐Deoxy‐β‐ribonucleosides.
Authors: Yang Fei , Zhu Yugen , Yu Biao 
Published: October 2012

AbstractThe stereoselectivity of the N‐glycosylation reaction of purines and uracils with hexynylbenzoate (I) depends on the concentration of the reaction solution leading to higher β/α‐ratio at lower concentrations.
Catalyst Recycling in Homogeneous Catalyzed Cross Metathesis of Methyl Oleate and 4‐Octene
Authors: Behr Arno , Gomes‐Jelonek Jessica , Witte Henning 
Published: October 2012

AbstractDas Recycling homogener Metathese‐Katalysatoren stellt eine große Herausforderung in der Alken‐Metathese dar. Im Rahmen der vorliegenden Arbeit wurde das Recycling von homogenen Rutheniumkomplex‐Katalysatoren am Beispiel der Kreuzmetathese von Ölsäuremethylester und 4‐Octen untersucht. Nach erfolgter Metathese wurden die Katalysatoren mithilfe der Flüssig‐Flüssig‐Zweiphasentechnik und der temperaturgesteuerten Mehrkomponenten‐Lösungsmittelsysteme von den Produkten erfolgreich abgetrennt. Die Katalysatorphase konnte bei nur geringem Ausbeuterückgang mehrfach erfolgreich wiedereingesetzt werden.
Answering biological questions by querying k‐mer databases
Authors: Greenfield Paul , Roehm Uwe 
Published: October 2012

SUMMARYThis paper describes a k‐mer approach to analysing DNA data and quickly answering certain types of ad hoc biological questions. These k‐mers (short DNA strings) are stored in a conventional relational database and indexed to support efficient exact match operations. We show that k‐mers around 20–25 bases long have interesting and useful uniqueness properties that can be used to compute a ‘relatedness’ metric and also allow k‐mers to be used as ‘unique enough’ tags to identify organisms and genes. This relatedness metric is used in SQL queries that can directly answer questions such as how two related species differ, and what genes are unique to an organism. The k‐mer tags have proven useful in applications, largely metagenomic ones that can quickly process large volumes of sequencing data to say something about what organisms and genes might be present in an environmental sample. All of this work is based on simple and fast exact matches of k‐mer strings using a database, rather than conventional alignment based on inexact matches of much longer strings. These k‐mer tools provide ways of rapidly exploring large genome spaces and handling large volumes of sequence data, and complement rather than replace existing alignment and assembly tools. Copyright © 2012 John Wiley & Sons, Ltd.
Magneto‐Structural Study of an Oxamato‐Bridged PdIICoII Chain: X‐ray Crystallographic Evidence of a Single‐Crystal‐to‐Single‐Crystal Phase Transition
Authors: Oliveira Willian X. C. , Ribeiro Marcos A. , Pinheiro Carlos B. , Nunes Wallace C. , Julve Miguel , Journaux Yves , Stumpf Humberto O. , Pereira Cynthia L. M. 
Published: October 2012

AbstractTwo new mononuclear oxamato‐containing palladium(II) complexes of formula K2[Pd(opba)]·2H2O (1) and (PPh4)2[Pd(opba)]·2H2O (2) and the heterodimetallic palladium(II)–cobalt(II) chain {[Co(H2O)2Pd(opba)]·dmso}n (3) [opba = 1,2‐phenylenebis(oxamate), PPh4+ = tetraphenylphosphonium cation and dmso = dimethyl sulfoxide] have been prepared, and the structures of two of them (compounds 2 and 3) were determined by X‐ray diffraction analysis of single crystals. The structure of 2 consists of discrete anions of [Pd(opba)2]2– and PPh4+ cations. Each PdII ion in 2 is surrounded by two oxamate nitrogen atoms and two carboxylate oxygen atoms in a square‐planar surrounding. Compound 3 is a neutral chain with regular alternating PdII and CoII ions, the [Pd(opba)]2– entity acting as a bis(bidentate) ligand towards trans‐diaquacobalt(II) fragments, and dmso molecules of crystallization. Compound 3 exhibits a single‐crystal‐to‐single‐crystal phase transition between monoclinic C2/c (α phase) and triclinic P$\bar {1}$ (β phase) space groups. Within the α phase the dmso molecule of crystallization is disordered, but it becomes ordered below 215 K in the β phase. The ordering process of the dmso molecule is followed by a reduction in the unit cell volume. The magnetic properties of 3 are barely affected by the structural phase transition, and they indicate an important spin–orbit coupling of the high‐spin octahedral CoII ion [α = 1.245, λ = –151 cm–1, Δ = 494 cm–1, the spin Hamiltonian being defined as H = –αλLS + Δ(Lz2–2/3) + βH(–αL + geS)] with an almost negligible intra‐ [through the diamagnetic square‐planar PdII centre] and interchain antiferromagnetic interactions (θ = –0.32 K).
Fast full‐color reflective display via photoluminescent enhancement
Authors: Gibson Gary , Sheng Xia , Henze Dick , Lam Si‐Ty , Beck Patricia , Jeon Yoocharn , Zhou Zhang‐Lin , Benson Brad , Liu Qin , Combs Gregg , Koch Tim , Biggs Kent 
Published: October 2012

AbstractReflective displays are advantageous in applications requiring low power or daylight readability. However, there are no low‐cost reflective technologies capable of displaying bright colors. By employing photoluminescence to more efficiently use ambient light, we created a prototype display that provides bright, full color in a simple, low‐cost architecture. This prototype includes a novel electrokinetic shutter, a layer that incorporates patterned luminescent red, green, and blue sub‐pixel elements, and a novel optical out‐coupling scheme. The luminescent elements convert otherwise‐wasted portions of the incident spectrum to light in the desired color band, resulting in improved color saturation and lightness. This prototype provides a color gamut that is superior to competing reflective display technologies that utilize color filters in single‐layer side‐by‐side sub‐pixel architectures. The current prototype is capable of switching in <0.5 s; future displays based on an alternative electro‐optic shutter technology should achieve video rate operation. A transflective version of this technology has also been prototyped. The transflective version utilizes its backlight with a power efficiency that is at least three times that of a conventional liquid crystal display. These photoluminescence‐based technologies enable a host of applications ranging from low‐power mobile products and retail pricing signage to daylight readable signage for outdoor advertising segments.