bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D technologies in STEAM education
Authors: Staribratov Ivaylo , Manolova Nikol 
Published: July 2024

AbstractThe article presents the application of 3D technologies in STEAM education through a conducted scientific research, highlighting the role of 3D modeling and 3D printing as an innovative approach in achieving an interdisciplinary learning model. The research included the following stages: preparation for designing a detailed 3D steam locomotive model; analysis of process difficulties; giving students and lecturers the opportunity to perform a specific modeling task, using basic primitives from solid geometry, as well as a questionnaire to analyze and evaluate the skills and knowledge of the participants in the 3D modeling field. In this context, the preparation process of a 3D steam locomotive model for educational purposes, using Autodesk 3ds Max software, is presented, and the 3D printing technology FDM is examined. We issued a challenge to the participants in the research to design a non-complex 3D model, using unfamiliar 3D modeling software Blender, within a limited time. The questionnaire covered topics in education, science, art, STEAM, and 3D modeling. The goal is to showcase the role of the integration of 3D technologies in educational environments with the idea of developing key skills and knowledge in learners.
Timing of Volatile Degassing From Hydrous Upper‐Crustal Magma Reservoirs With Implications for Porphyry Copper Deposits
Authors: Gruzdeva Yulia , Weis Philipp , Andersen Christine 
Published: July 2024

AbstractThe timing and duration of volatile generation from crystallizing magma reservoirs and fluid release across the magmatic‐hydrothermal interface depend on complex coupled interactions controlled by non‐linear, dynamic properties of magmas, rocks and fluids. Understanding these mechanisms is essential to explain the rare formation of economic porphyry copper deposits. For this study, we further developed a coupled numerical model that can simultaneously resolve magma and hydrothermal flow by introducing a description of fluid transport within the magma reservoir and volatile release to the host rock. Our simulations use realistic magma properties derived from published experimental and modeling studies and cover different magma compositions and water contents. We show that magma convection at melt‐dominated states leads to homogenization, which delays fluid release and promotes a rapid evolution toward a mush state. The onset of magmatic volatile release can be near‐explosive with a tube‐flow outburst event lasting <100 years for high initial water contents of >3.5 wt% H2O that could result in the formation of hydrothermal breccias and vein stockworks or trigger eruptions. This event can be followed by sustained fluid release at moderate rates by volatile flushing caused by magma convection. Subsequent fluid release from concentric tube rings by radial cooling of non‐convecting magma mush with a volume of ∼100 km3 at ∼5 km depth is limited to remaining water contents of ∼3.1 wt% H2O and lasts 50–100 kyr. Ore formation from hydrous magmas may thus involve distinct phases of volatile release.
Generation and Impacts of Whistler‐Mode Waves During Energetic Electron Injections in Jupiter's Outer Radiation Belt
Authors: Ma Q. , Li W. , Zhang X.‐J. , Bortnik J. , Shen X.‐C. , Daly A. , Kurth W. S. , Mauk B. H. , Allegrini F. , Connerney J. E. P. , Bagenal F. , Bolton S. J. 
Published: July 2024

AbstractEnergetic particle injections are commonly observed in Jupiter's magnetosphere and have important impacts on the radiation belts. We evaluate the roles of electron injections in the dynamics of whistler‐mode waves and relativistic electrons using Juno measurements and wave‐particle interaction modeling. The Juno spacecraft observed injected electron flux bursts at energies up to 300 keV at M shell ∼11 near the magnetic equator during perijove‐31. The electron injections are related to chorus wave bursts at 0.05–0.5 fce frequencies, where fce is the electron gyrofrequency. The electron pitch angle distributions are anisotropic, peaking near 90° pitch angle, and the fluxes are high during injections. We calculate the whistler‐mode wave growth rates using the observed electron distributions and linear theory. The frequency spectrum of the wave growth rate is consistent with that of the observed chorus magnetic intensity, suggesting that the observed electron injections provide free energy to generate whistler‐mode chorus waves. We further use quasilinear theory to model the impacts of chorus waves on 0.1–10 MeV electrons. Our modeling shows that the chorus waves could cause the pitch angle scattering loss of electrons at <1 MeV energies and accelerate relativistic electrons at multiple MeV energies in Jupiter's outer radiation belt. The electron injections also provide an important seed population at several hundred keV energies to support the acceleration to higher energies. Our wave‐particle interaction modeling demonstrates the energy flow from the electron injections to the relativistic electron population through the medium of whistler‐mode waves in Jupiter's outer radiation belt.
Wind‐Enhanced Separation of Large‐Scale River Plumes From Coastal Corners
Authors: Whitney Michael M. 
Published: July 2024

AbstractIdealized models are analyzed to quantify how large‐scale river plumes interact with coastal corners with and without wind‐driven currents. The configuration has a corner formed by two perpendicular shelves (with constant slope) that are joined with a coastal radius of curvature (rc). The buoyant plume originates from an upstream point source. The rc and wind forcing are varied among runs. Steep‐ and gentle‐slope runs are compared for some situations. Without winds, plumes separate from corners with rc smaller than two inertial radii (ri); this threshold is twice the rc < ri theoretical separation criterion. After separation, no‐wind plumes form an anticyclonic bulge, and reattach farther downstream. Offshore excursion increases as rc decreases. A downwelling‐favorable wind component along the upstream coast (τsx) favors separation by increasing total plume speed. An upwelling‐favorable wind component along the downstream coast (τsy) also increases offshore excursion. Winds blowing obliquely offshore with both these wind components advect the plume farther offshore. Wind‐driven currents that steer plumes in this situation include a downshelf jet originating on the upstream shelf and continuing around the coastal corner and beyond, offshore and upshelf surface transport downstream of the corner, and surface Ekman transport on the outer shelf. Multiple linear regressions quantify plume position sensitivity to rc, τsx, and τsy; results are discussed in a dynamical context. Globally, many river plumes interact with coastal corners under various wind conditions.
To Exascale and Beyond—The Simple Cloud‐Resolving E3SM Atmosphere Model (SCREAM), a Performance Portable Global Atmosphere Model for Cloud‐Resolving Scales
Authors: Donahue A. S. , Caldwell P. M. , Bertagna L. , Beydoun H. , Bogenschutz P. A. , Bradley A. M. , Clevenger T. C. , Foucar J. , Golaz C. , Guba O. , Hannah W. , Hillman B. R. , Johnson J. N. , Keen N. , Lin W. , Singh B. , Sreepathi S. , Taylor M. A. , Tian J. , Terai C. R. , Ullrich P. A. , Yuan X. , Zhang Y. 
Published: July 2024

AbstractThe new generation of heterogeneous CPU/GPU computer systems offer much greater computational performance but are not yet widely used for climate modeling. One reason for this is that traditional climate models were written before GPUs were available and would require an extensive overhaul to run on these new machines. In addition, even conventional “high–resolution” simulations don't currently provide enough parallel work to keep GPUs busy, so the benefits of such overhaul would be limited for the types of simulations climate scientists are accustomed to. The vision of the Simple Cloud‐Resolving Energy Exascale Earth System (E3SM) Atmosphere Model (SCREAM) project is to create a global atmospheric model with the architecture to efficiently use GPUs and horizontal resolution sufficient to fully take advantage of GPU parallelism. After 5 years of model development, SCREAM is finally ready for use. In this paper, we describe the design of this new code, its performance on both CPU and heterogeneous machines, and its ability to simulate real‐world climate via a set of four 40 day simulations covering all 4 seasons of the year.
A recommendation for the use of electrical biosensing technology in neonatology
Authors: van Wyk Lizelle , Austin Topun , Barzilay Bernard , Bravo Maria Carmen , Breindahl Morten , Czernik Christoph , Dempsey Eugene , de Boode Willem-Pieter , de Vries Willem , Eriksen Beate Horsberg , Fauchére Jean-Claude , Kooi Elisabeth M. W. , Levy Philip T. , McNamara Patrick J. , Mitra Subhabrata , Nestaas Eirik , Rabe Heike , Rabi Yacov , Rogerson Sheryle R. , Savoia Marilena , Schena Frederico , Sehgal Arvind , Schwarz Christoph E. , Thome Ulrich , van Laere David , Zaharie Gabriela C. , Gupta Samir ,   ESPR Special Interest Group on Non-Invasive Cardiac Output Monitoring, van Wyk Lizelle , de Boode Willem-Pieter , de Vries Willem , van Laere David 
Published: July 2024

Abstract
Non-invasive cardiac output monitoring, via electrical biosensing technology (EBT), provides continuous, multi-parameter hemodynamic variable monitoring which may allow for timely identification of hemodynamic instability in some neonates, providing an opportunity for early intervention that may improve neonatal outcomes. EBT encompasses thoracic (TEBT) and whole body (WBEBT) methods. Despite the lack of relative accuracy of these technologies, as compared to transthoracic echocardiography, the use of these technologies in neonatology, both in the research and clinical arena, have increased dramatically over the last 30 years. The European Society of Pediatric Research Special Interest Group in Non-Invasive Cardiac Output Monitoring, a group of experienced neonatologists in the field of EBT, deemed it appropriate to provide recommendations for the use of TEBT and WBEBT in the field of neonatology. Although TEBT is not an accurate determinant of cardiac output or stroke volume, it may be useful for monitoring longitudinal changes of hemodynamic parameters. Few recommendations can be made for the use of TEBT in common neonatal clinical conditions. It is recommended not to use WBEBT to monitor cardiac output. The differences in technologies, study methodologies and data reporting should be addressed in ongoing research prior to introducing EBT into routine practice.

Impact statement

TEBT is not recommended as an accurate determinant of cardiac output (CO) (or stroke volume (SV)).

TEBT may be useful for monitoring longitudinal changes from baseline of hemodynamic parameters on an individual patient basis.

TEBT-derived thoracic fluid content (TFC) longitudinal changes from baseline may be useful in monitoring progress in respiratory disorders and circulatory conditions affecting intrathoracic fluid volume.

Currently there is insufficient evidence to make any recommendations regarding the use of WBEBT for CO monitoring in neonates.

Further research is required in all areas prior to the implementation of these monitors into routine clinical practice.
The 2023 Doyne Lecture—a cornea care system: evolution
Authors: Rao Gullapalli N. 
Published: July 2024

AbstractBlindness and visual impairment affect the quality of life of the individual and their family members. Corneal opacities are a key cause of vision loss around the world, especially in low-income and middle-income countries (LMIC). Corneal blindness and vision loss impacts every age group, and the risk factors and the causes are also varied. Socio-economic factors also play a significant role in its prevalence. Preventing, treating, and managing corneal conditions in LMIC contexts can therefore be quite complex and challenging. A model of eye care delivery developed and refined over the past four decades, the L V Prasad Eye Institute’s cornea care system presents an example and a sense of hope. The model takes corneal care from world-class facilities in urban locations to rural locations, overcoming a variety of challenges. The initial breakthrough came with solving and ensuring a steady supply of corneal tissue. Then to training high-quality resources, building capacity, and investing in research that translates from the bench to the bedside. A variety of innovations, both in diagnosis and the operating theatre, have paved for improved outcomes that are tailored for the contexts in which this system operates. The institute envisions a future where its work further narrows the gap in eye care disparities and leads to life-changing impact in ophthalmic care of the cornea.
Risks and regulation of rubber scattershot in Switzerland: a narrative review
Authors: Fierz Anna 
Published: July 2024

AbstractMultiple kinetic impact projectiles (KIPs) are responsible for most eye injuries by crowd-control weapons. This review aims to outline an underreported, ongoing series of eye injuries by rubber scattershot in Switzerland, and to relate current knowledge about thresholds for lasting visual loss to the energy limits set on KIPs in crowd control, by way of a retrospective compilation of cases from publicly available records and a review of the pertinent literature. Scattershot can cause irreversible visual loss. Since 1980, there have been 36 known cases of eye injuries by rubber pellets in Switzerland. In 2023, the incidence was higher here than at the peak of protests in France. KIPs were originally cleared for use in crowd control at kinetic and area-normalised energies assumed to lie below the threshold for ocular penetration. However, closed globe injuries suffice to cause permanent visual loss. Lower energy thresholds for lasting damage have been confirmed by the newer literature on paintballs, airbags, air guns and toys. These values may differ in vivo versus in vitro, and in humans versus in animals. There is no clear consensus on how best to predict loss of vision. Underreporting the risks of crowd-control weapons may contribute to their prolonged and increasingly liberal use. Regulations should consider what is known on energy thresholds for permanent visual loss. It is critical for ophthalmologists to be involved in the evaluation and monitoring of eye injuries caused by projectiles, including KIPs and toys. An interdisciplinary approach could help to elucidate damage thresholds.
Telomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding
Authors: Zhang Yilin , Zhao Mingxia , Tan Jingsheng , Huang Minghan , Chu Xiao , Li Yan , Han Xue , Fang Taohong , Tian Yao , Jarret Robert , Lu Dongdong , Chen Yijun , Xue Lifang , Li Xiaoni , Qin Guochen , Li Bosheng , Sun Yudong , Deng Xing Wang , Deng Yun , Zhang Xingping , He Hang 
Published: July 2024

AbstractTo decipher the genetic diversity within the cucurbit genus Citrullus, we generated telomere-to-telomere (T2T) assemblies of 27 distinct genotypes, encompassing all seven Citrullus species. This T2T super-pangenome has expanded the previously published reference genome, T2T-G42, by adding 399.2 Mb and 11,225 genes. Comparative analysis has unveiled gene variants and structural variations (SVs), shedding light on watermelon evolution and domestication processes that enhanced attributes such as bitterness and sugar content while compromising disease resistance. Multidisease-resistant loci from Citrullus amarus and Citrullus mucosospermus were successfully introduced into cultivated Citrullus lanatus. The SVs identified in C. lanatus have not only been inherited from cordophanus but also from C. mucosospermus, suggesting additional ancestors beyond cordophanus in the lineage of cultivated watermelon. Our investigation substantially improves the comprehension of watermelon genome diversity, furnishing comprehensive reference genomes for all Citrullus species. This advancement aids in the exploration and genetic enhancement of watermelon using its wild relatives.
Multivariate analysis of the summer herbaceous vegetation and environmental factors of the sub-tropical region
Authors: Ullah Tahseen , Muhammad Zahir , Shah Ishaq Ali , Bourhia Mohammed , Nafidi Hiba-Allah , Mohammad Salamatullah Ahmad , Ali Younous Youssouf 
Published: July 2024

AbstractUnderstanding the distribution of the plant species of an unexplored area is the utmost need of the present-day. In order to collect vegetation data, Quadrat method was used having size of 1 m2. The composite soil samples from each site were tested for various edaphic properties. PC-ORD v.5 was used for the classification of the vegetation while CANOCO v.5.1 was used for ordination of the data and to find out the complex relationship between plants and environment. Survey was conducted during summer season and a total of 216 herbaceous species were recorded from forty different sites of District Kohat, Pakistan. Cluster Analysis (CA) and Two-Way Cluster Analysis (TWCA) classified the vegetation of forty sites into six major plant groups i.e., 1. Paspalum paspalodes, Alternanthera sessilis, Typha domingensis, 2. Cynodon dactylon, Parthenium hysterophorus, Brachiaria ramosa, 3. Cynodon dactylon, Eragrostis minor, Cymbopogon jwarancusa, 4. Cymbopogon jwarancusa, Aristida adscensionis, Boerhavia procumbens, 5. Cymbopogon jwarancusa, Aristida adscensionis, Pennisetum orientale and 6. Heteropogon contortus, Bothriochloa ischaemum, Chrysopogon serrulatus. They were named after the dominant species based on their Importance Value (IV). The detrended correspondence analysis (DCA) analysis further confirmed the vegetation classification. Canonical correspondence analysis (CCA) indicated that the species distribution in the area was strongly affected by various environmental factors including status, soil characteristics, topography and altitude.
A DFT study of superior adsorbate–surface bonding at Pt-WSe2 vertically aligned heterostructures upon NO2, SO2, CO2, and H2 interactions
Authors: Kushwaha Aditya , Goel Neeraj 
Published: July 2024

AbstractThis study investigates the potential of platinum (Pt) decorated single-layer WSe2 (Pt-WSe2) monolayers as high-performance gas sensors for NO2, CO2, SO2, and H2 using first-principles calculations. We quantify the impact of Pt placement (basal plane vs. vertical edge) on WSe2’s electronic properties, focusing on changes in bandgap (ΔEg). Pt decoration significantly alters the bandgap, with vertical edge sites (TV-WSe2) exhibiting a drastic reduction (0.062 eV) compared to pristine WSe2 and basal plane decorated structures (TBH: 0.720 eV, TBM: 1.237 eV). This substantial ΔEg reduction in TV-WSe2 suggests a potential enhancement in sensor response. Furthermore, TV-WSe2 displays the strongest binding capacity for all target gases due to a Pt-induced “spillover effect” that elongates adsorbed molecules. Specifically, TV-WSe2 exhibits adsorption energies of − 0.5243 eV (NO2), − 0.5777 eV (CO2), − 0.8391 eV (SO2), and − 0.1261 eV (H2), indicating its enhanced sensitivity. Notably, H2 adsorption on TV-WSe2 shows the highest conductivity modulation, suggesting exceptional H2 sensing capabilities. These findings demonstrate that Pt decoration, particularly along WSe2 vertical edges, significantly enhances gas sensing performance. This paves the way for Pt-WSe2 monolayers as highly selective and sensitive gas sensors for various applications, including environmental monitoring, leak detection, and breath analysis.
CCR2+ monocytes/macrophages drive steroid hormone imbalance-related prostatic fibrosis
Authors: Popovics Petra , Silver Samara V. , Uchtmann Kristen S. , Arendt Lisa M. , Vezina Chad M. , Ricke William A. 
Published: July 2024

AbstractBenign Prostatic Hyperplasia (BPH) is a complex condition leading to Lower Urinary Tract Symptoms in aging men, characterized by cellular proliferation, smooth muscle dysfunction, inflammation, and fibrosis. While BPH is known to involve heightened macrophage infiltration, the specific contribution of infiltrating monocytes/macrophages to the disease mechanism remains uncertain. This research explores the impact of reducing circulating monocytes and subsequently limiting their tissue infiltration by using Ccr2 knockout (Ccr2-KO) mice. Ccr2-KO and wild type mice were implanted with testosterone and estradiol (T + E2, 25 mg + 2.5 mg) pellets. Urinary function was assessed via weekly void spot assays over 12 weeks, and prostatic macrophage levels were visualized and quantified in tissue sections using an F4/80 antibody. Additionally, Ki-67 staining was used to evaluate cell proliferation, and picrosirius red staining to assess collagen accumulation. Increased voiding frequency which developed in T + E2 mice, was significantly ameliorated in Ccr2-KO mice, however, both Ccr2-KO and wild type (WT) mice showed increased bladder weights after three month, representing a hypertrophic response to bladder outlet obstruction. T + E2 substantially increased the density of macrophages in WT but not Ccr2-KO mouse prostate. Proliferation rate, as indicated by Ki-67 positivity, was elevated in the vental and anterior prostate lobes but was only marginally reduced in Ccr2-KO mice. Most importantly, a significant prostatic collagen accumulation was observed in WT mice that was markedly reduced by Ccr2 deficiency post T + E2 treatment. The absence of Ccr2 mitigates urinary dysfunction and alters prostatic macrophage levels and collagen accumulation in steroid hormone imbalance. These findings suggest a crucial role for monocyte infiltration, giving rise to macrophages or other cell derivatives, to drive fibrosis.
Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort
Authors: Sakurai Miyuki , Motoike Ikuko N. , Hishinuma Eiji , Aoki Yuichi , Tadaka Shu , Kogure Mana , Orui Masatsugu , Ishikuro Mami , Obara Taku , Nakaya Naoki , Kumada Kazuki , Hozawa Atsushi , Kuriyama Shinichi , Yamamoto Masayuki , Koshiba Seizo , Kinoshita Kengo 
Published: July 2024

AbstractUnderstanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55–59 to 60–64 years being a period of significant metabolic change, particularly in men, and from 45–49 to 50–54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.