bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Ultra‐Sensitive Electrochemical Sensor for Nitrite Based on Green Synthesized Gold Nanoparticles Using Colocasia Esculenta Extract
Authors: Saha Protity , Aziz Md. Abdul , Islam Md. Mominul , Saleh Ahammad A. J. 
Published: August 2024

AbstractSeeking to establish a novel, eco‐friendly and ultra‐ sensitive electrochemical nitrite sensor, we have fabricated fluorine doped tin oxide (FTO) electrode with green synthesized gold nanoparticles (AuNPs) from gold salt and taro plant (Colocasia esculenta) extract (Taro_AuNPs/FTO). Different morphological and elemental analysis were conducted to undermine morphological condition and shapes of AuNPs. Further, electrochemical studies were performed for enabling observation on the modification as well as interaction between nitrite ion and AuNPs on the modified FTO. Furthermore, the performance of Taro_AuNPs/FTO sensor was evaluated using DPV technique and the limit of detection (LOD) was 0.923 nmol L−1 (S/N=3) having sensitivity of 0.00503 μA mM−1 cm−2 within 5–500 μmol L−1. Additionally, an insightful mechanistic overview was highlighted about interacting nitrite on the modified electrode surface. Finally, interference test, stability, reproducibility and real sample analysis were conducted to establish the effectiveness of Taro_AuNPs/FTO electrochemical senor for environmental application.
The impact of competition on environmental and social performance in the MENA banking sector
Authors: Maside‐Sanfiz José Manuel , Iglesias‐Casal Ana , Mazahreh Qusay Ayman Sulayman , López‐Penabad Mª. Celia 
Published: August 2024

AbstractThe study analyzes the impact of competition on environmental and social performance. Based on data collected from 82 banks in the banking industry across nine emerging Middle Eastern and North African (MENA) countries from 2015 to 2021, the results indicate that heightened competitive pressure compels banks to enhance their efforts in environmental and social initiatives. Additionally, a positive correlation is observed between greater Board gender diversity (BGD) and improved environmental and social performance. Finally, the results indicate that the negative impact of market power on environmental and social performance is less pronounced in banks with higher BGD, those operating in countries with a better institutional environment, and in state‐owned banks. In contrast, the negative impact is more pronounced in Islamic banks. Our research findings provide insights into the current discourse on strategic decision‐making in the context of sustainability, shedding light on the benefits associated with competition and gender diversity.
Surface State Modulation via Electrochemical Heterogeneous Redox Reactions for Full‐Color Emission Carbon Dots
Authors: Li Jinli , Sun Chengxiang , Li Qiang , Xu Xiran , Li Baolin , Tian Yijia , Zheng Dianyuan , Yao Rongbin , Yuan Kang , Guo Ziyang 
Published: August 2024

AbstractCarbon dots (CDs) still suffer from unclear surface state fluorescence mechanism for fine modulation. Here, redox reactions for cathode and anode within electrochemical method are firstly employed to construct differentiated strategy for surface‐state modulation, so as to obtain CDs with controllable emission in separated electrodes simultaneously. The fluorescence peaks of CDs from blue to red centered at 425 nm (mCDs−), 530 nm (mCDs+), 580 nm (oCDs−) and 665 nm (oCDs+) are mainly originated from the different bombardment effects of the ions and reaction tendencies of modifier during the electrolysis process. The phenylenediamine (as modifier) tends to introduce the amino groups on the surface of CDs‐ while introduced nitrogen atoms into the carbon nucleus skeleton around the anode, thus leading to much larger size and the formation of the graphite N for CDs+. It is the different surface states formed by phenylenediamine and the absorption redshift triggered by graphite N that ensures the tunable emission. The improved electrochemical method is of great significance for finely spectra modulation and efficient synthesis.
Transcription factor Meis1b regulates craniofacial morphogenesis in zebrafish
Authors: Psutkova Viktorie , Nickl Petr , Brezinova Veronika , Machonova Olga , Machon Ondrej 
Published: August 2024

AbstractBackgroundMeis family of transcription factors operates in Pbx‐Meis‐Hox regulatory network controlling development of various tissues including eye, limbs, heart, hindbrain or craniofacial skeletal elements originating from the neural crest. Although studies in mouse provide abundant information about Meis factors function in embryogenesis, little is known about their role in zebrafish.ResultsWe generated zebrafish lines carrying null mutations in meis1a, meis1b, meis2a, and meis2b genes. Only meis1b mutants are lethal at larval stage around 13 dpf whereas the other mutant lines are viable and fertile. We focused on development of neural crest‐derived craniofacial structures such as tendons, cranial nerves, cartilage and accompanying muscles. Meis1b mutants displayed morphogenetic abnormalities in the cartilage originating from the first and second pharyngeal arches. Meckel's cartilage was shorter and wider with fused anterior symphysis and abnormal chondrocyte organization. This resulted in impaired tendons and muscle fiber connections while tenocyte development was not largely affected.ConclusionsLoss‐of‐function mutation in meis1b affects cartilage morphology in the lower jaw that leads to disrupted organization of muscles and tendons.
Aziridination Exploited: A Mechanistic Study of the Divergent Reactivity of Trifluoropropenyl‐iodonium Reagent toward N‐nucleophiles
Authors: Fehér Péter Pál , Béke Ferenc , Csenki János T. , Novák Zoltán , Stirling András 
Published: August 2024

AbstractIn this study, we use computations and experiments to explore mechanistic scenarios that govern the reaction between secondary amines and trifluoropropenyl iodonium triflate with the aim of rationalizing and predicting experimental outcomes. Based on the results from theory, we have compiled a list of guidelines relevant to synthetic strategies and provide examples for the interpretation of selectivities. To demonstrate the viability of these strategies, we have performed directed experiments applying different reaction conditions to obtain the products predicted by our model. Additionally, qualitative microkinetic simulations based on our computations were carried out for further support.
Inter‐ and intra‐subject similarity in network functional connectivity across a full narrative movie
Authors: Mochalski Lisa N. , Friedrich Patrick , Li Xuan , Kröll Jean‐Philippe , Eickhoff Simon B. , Weis Susanne 
Published: August 2024

AbstractNaturalistic paradigms, such as watching movies during functional magnetic resonance imaging, are thought to prompt the emotional and cognitive processes typically elicited in real life situations. Therefore, naturalistic viewing (NV) holds great potential for studying individual differences. Previous studies have primarily focused on using shorter movie clips, geared toward eliciting specific and often isolated emotions, while the potential behind using full narratives depicted in commercial movies as a proxy for real‐life experiences has barely been explored. Here, we offer preliminary evidence that a full narrative movie (FNM), that is, a movie covering a complete narrative arc, can capture complex socio‐affective dynamics and their links to individual differences. Using the studyforrest dataset, we investigated inter‐ and intra‐subject similarity in network functional connectivity (NFC) of 14 meta‐analytically defined networks across a full narrative, audio‐visual movie split into eight consecutive movie segments. We characterized the movie segments by valence and arousal portrayed within the sequences, before utilizing a linear mixed model to analyze which factors explain inter‐ and intra‐subject similarity. Our results show that the model best explaining inter‐subject similarity comprised network, movie segment, valence and a movie segment by valence interaction. Intra‐subject similarity was influenced significantly by the same factors and an additional three‐way interaction between movie segment, valence and arousal. Overall, inter‐ and intra‐subject similarity in NFC were sensitive to the ongoing narrative and emotions in the movie. We conclude that FNMs offer complex content and dynamics that might be particularly valuable for studying individual differences. Further characterization of movie features, such as the overarching narratives, that enhance individual differences is needed for advancing the potential of NV research.
A call for action to stop sexual violence against women in the Democratic Republic of Congo: A brief report
Authors: Nyakio Olivier , Mukwege Denis , Balagizi Fabien , Oduoye Malik Olatunde , Banga Styves , Onesime Jones , Bhattacharjee Priyadarshini , Elembwe Hardy , Cakwira Hugues , Kihanduka Elie , Amiri Afissa , Rugendabanga Excellent , Hangi Samson , Makungu Chloe , Akilimali Aymar 
Published: August 2024

SynopsisSexual violence in the Democratic Republic of Congo is also described as a weapon of war.
Recombinant erythropoietin for the treatment of iron deficiency anemia in pregnancy: A systematic review
Authors: Levy Ariel T. , Weingarten Sarah J. , Robinson Keely , Suner Talia , McLaren Rodney A. , Saad Antonio , Al‐Kouatly Huda B. 
Published: August 2024

AbstractBackgroundTreatment options for severe, refractory iron deficiency anemia are limited in pregnancy.ObjectiveTo review the available literature on the use of recombinant erythropoietin in the treatment of iron deficiency anemia in pregnancy.Search StrategyAn electronic search of seven databases from inception to March 2022 was performed using a combination of keywords.Selection CriteriaWe included all randomized controlled or observational studies of pregnant patients with iron deficiency anemia who received recombinant erythropoietin or control. The primary outcome was a change in hematologic parameters (hemoglobin or hematocrit) after treatment. Studies were appraised using the criteria outlined in the Cochrane Handbook for Systematic Reviews of Interventions.Data Collection and AnalysisData were summarized using narrative synthesis and descriptive statistics as appropriate. This study was registered with PROSPERO, CRD42022313328.Main ResultsOf 234 studies screened, five studies met the inclusion criteria and had sufficient data for analysis (n = 103 recombinant erythropoietin and n = 104 controls). All patients in the intervention group received iron supplementation (intravenous or oral) in addition to recombinant erythropoietin. All patients in the control group received iron supplementation (intravenous or oral) alone. As the result of variance between studies in inclusion criteria, the timing of repeat blood draws, and data reporting, a meta‐analysis could not be performed. Three studies found that serial recombinant erythropoietin combined with iron supplementation was more effective at raising hematologic laboratory parameters (hemoglobin or hematocrit) than iron alone. One study reported no difference in hemoglobin or hematocrit levels between groups at day 28. However, patients in this study only received one dose of recombinant erythropoietin, whereas those in the other studies received serial doses. Another study also found no difference in hemoglobin levels by day 28, but patients in the recombinant erythropoietin group had lower hemoglobin levels at baseline and a more rapid rise in hemoglobin than iron alone. This is demonstrated by a more significant rise in hemoglobin at day 11 in the recombinant erythropoietin group than in the control group.ConclusionsSerial recombinant erythropoietin administration and iron supplementation may be more effective at treating refractory iron deficiency anemia in pregnancy than iron supplementation alone.
Pregnancy after advanced ovarian cancer with spontaneous uterine rupture in second trimester: A case report and review of the literature
Authors: Lukac Stefan , Wenzel Robin , Schochter Fabienne , Friebe‐Hoffmann Ulrike , Hüner Beate , Janni Wolfgang 
Published: August 2024

AbstractFertility‐preserving surgery (FPS) in advanced ovarian cancer (AOC) is extremely rare and consequently, information about the pregnancies of these patients is anecdotal. Therefore, management of the pregnancy after AOC is challenging, especially if an unexpected situation arises. A 31‐year‐old nulliparous woman was admitted to our tertiary hospital in the 18th week of twin pregnancy with sudden severe abdominal pain. Her medical history included a low‐grade AOC stage IIIc diagnosed 2 years before pregnancy and treated by debulking FPS and systemic therapy with carboplatin/paclitaxel and bevacizumab. Clinical examination described normal vital signs and peritoneal irritation without any vaginal discharge. Sonography revealed free fluid in the pouch of Douglas and intact twin pregnancy. Laboratory work showed elevated leukocytes with neutrophilia. To evaluate appendicitis magnetic resonance imaging of the abdomen was indicated. This revealed a uterine rupture with the now extra‐cavitary position of the twins. Simultaneously, the patient's symptoms deteriorated, and emergency surgery was necessary where hemoperitoneum with avital fetuses were present. Despite excessive blood loss the uterus could be repaired and preserved. Previous resection of the uterine serosa during her debulking FPS, administration of bevacizumab affecting smooth muscles, and overstretching the uterus in the twin pregnancy were considered as possible risk factors for the presenting uterine rupture. Pregnancy after AOC is possible but should be monitored closely, especially due to the hidden long‐term consequences of its therapy. In the differential diagnosis of sudden abdominal pain during pregnancy uterine rupture should be considered even in patients with an unscared uterus.
Application of advanced biosensors in nervous system diseases
Authors: Meng Zexuan , Zhang Yuchan , Yang Lu , Yuan Feng , Wang Jian , Chen Jiajia , Liu Jun , Wang Guixue , Zang Guangchao 
Published: August 2024

AbstractNervous system diseases are among the most common diseases globally, posing a severe threat to patients' quality of life and placing a considerable burden on families and society. With improvements in miniaturization, intelligence, and the safety of biosensors, the combination of machinery and organisms is becoming increasingly common. In neuroscience research, biosensors of different macroscopic dimensions have been uniquely utilized to harness their relevant properties. One‐dimensional (1D) biosensors can achieve in situ real‐time monitoring of neural markers at the subcellular, single‐cell, ex vivo, and in vivo levels, with reduced impacts on organisms. Two‐dimensional (2D) biosensors can monitor the chemical behavior of cells and the neural activity of living animals. They are helpful for objectively identifying the characteristics of cells in response to external stimuli and studying the neural circuits of living animals. Three‐dimensional (3D) biosensors have shown unique advantages in point‐of‐care testing, liquid biopsy, drug screening, and mechanistic research. In clinical practice, brain‐computer interfaces (BCIs) and wearable devices have become important tools for monitoring and treatment. To date, there has been widespread adoption of BCIs in clinical practice. BCIs not only exhibit good efficacy in severe neurological and mental diseases but also provide a method for early diagnosis and treatment of these diseases. Wearable sensor devices can accurately assess the symptoms of movement disorders and play an active role in rehabilitation and treatment. In this review, we summarize the application of advanced biosensors in neuroscience research and clinical practice. The challenges and prospects of biosensors as applied to nervous system diseases under interdisciplinary promotion are also discussed in depth.
Influence of Dapagliflozin Dosing on Low‐Density Lipoprotein Cholesterol in Type 2 Diabetes Mellitus: A Systematic Literature Review and Meta‐Analysis
Authors: Martha Srinivas , Jangam Preethi Hepzibah , Bhansali Suraj G. 
Published: August 2024

AbstractA systematic literature review and meta‐analysis was performed to evaluate the effects of dapagliflozin on low‐density lipoprotein (LDL) cholesterol in type 2 diabetes mellitus. Data on changes in LDL cholesterol, adverse cardiac events (ACEs), glycated hemoglobin (HbA1c), and fasting blood glucose (FBG) were pooled in a meta‐analysis. Data from dose comparison trials were separately pooled, and meta‐analysis was conducted by using RevMan (5.4.1) and R (4.1.2). Dapagliflozin increased LDL cholesterol by 2.33 mg/dL (95% CI, 1.46 to 3.19; I2 = 0%; P < .00001), increased risk of ACEs by 1.56 (95% CI, 1.02 to 2.39; I2 = 0%; P < .04), decreased HbA1c by −0.41% (95% CI, −0.44 to −0.39; I2 = 85%; P < .00001), and decreased FBG by −13.51 mg/dL (95% CI, −14.43 to −12.59; I2 = 92%; P < .00001) versus any placebo or active comparator. Dapagliflozin 10 mg monotherapy increased LDL cholesterol by 1.71 mg/dL (95% CI, −1.20 to 4.62; I2 = 53%; P = .25) versus a 5 mg dose and by 1.04 mg/dL (95% CI, −1.17 to 3.26; I2 = 62%; P = .36) versus a 2.5 mg dose. Dapagliflozin 10 mg monotherapy increased LDL cholesterol by 3.13 mg/dL (95% CI, 1.31 to 4.95; I2 = 0%; P = .0008), increased the risk of ACEs by 1.26 (95% CI, 0.56 to 2.87; I2 = 0%; P = .58), decreased HbA1c by −0.4% (95% CI, −0.45 to −0.35; I2 = 89%; P < .00001), and decreased FBG by −8.39 mg/dL (95% CI, −10 to −6.77; I2 = 96%; P < .00001) versus a placebo or active comparator. Dapagliflozin monotherapy resulted in a minimal but statistically significantly (P = .0002) increase in LDL cholesterol. However, this minor change does not increase the risk of ACEs (P = .17) when compared with placebo or active comparator.
A phase 1b/2 study evaluating efficacy and safety of MP0250, a designed ankyrin repeat protein (DARPin) simultaneously targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib and dexamethasone, in patients with relapsed or refractory multiple myeloma
Authors: Knop Stefan , Szarejko Monika , Grząśko Norbert , Bringhen Sara , Trautmann‐Grill Karolin , Jurczyszyn Artur , Vacca Angelo , Khandanpour Cyrus , Gamberi Barbara , Pour Ludek , Iversen Katrine F. , Stumpp Michael T. , Suter Cosima , Dawson Keith M. , Zitt Christof , Legenne Philippe , Stavropoulou Vaia , Fey Martin F. , Leupin Nicolas , Goldschmidt Hartmut 
Published: August 2024

AbstractMP0250 is a designed ankyrin repeat protein that specifically inhibits both vascular endothelial growth factor A (VEGF‐A) and hepatocyte growth factor (HGF), aiming at potentiating cancer therapy by disrupting the tumour microenvironment. Encouraging results from a phase 1 trial of MP0250 in patients with solid tumours prompted further investigation in multiple myeloma (MM) as both MP0250 targets are reported to be drivers of MM pathogenesis.In this open‐label, single‐arm phase 1b/2 study (NCT03136653) in patients with proteasome inhibitor‐ and/or immunomodulatory drug‐relapsed or refractory MM, MP0250 was administered every 3 weeks with standard bortezomib/dexamethasone regimen.Thirty‐three patients received at least one dose of MP0250. The most frequent treatment‐related adverse events were arterial hypertension (58.1%), thrombocytopenia (32.3%), proteinuria (29.0%) and peripheral oedema (19.4%). Of the 28 patients evaluable for response (median age: 60 [range 44–75]), nine achieved at least partial response, corresponding to an overall response rate of 32.1% (95% confidence interval [CI]: 17.9%, 50.7%), with a median duration of response of 8 months (95% CI 5–NR). An additional three patients achieved minimal response and nine stable diseases as the best overall response. Overall median progression‐free survival was 4.2 months (95% CI 1.9–7.1).These findings are in line with the results of recent trials testing new agents on comparable patient cohorts and provide initial evidence of clinical benefit for patients with refractory/relapsed MM treated with MP0250 in combination with bortezomib/dexamethasone. Further clinical evaluation in the emerging MM treatment landscape would be required to confirm the clinical potential of MP0250.
When development cooperation principles clash: Country ownership and LGBTQI+ inclusion in hostile environments
Authors: Brown Stephen 
Published: August 2024

AbstractIn some instances, two basic development cooperation principles appear to be in direct contradiction: on the one hand, the Sustainable Development Goals prescribe universal social inclusion under the leitmotif of “leave no one behind”, mandating an emphasis on the most marginalized. On the other hand, the cornerstone of development cooperation is “ownership”, which recognizes that countries must be free to choose their own priorities and strategies. To what extent can these two principles be reconciled in “hostile environments”, places where certain groups, such as LGBTQI+ people, are marginalized and even persecuted and criminalized? I argue that, while the SDGs are clear about the need for radical inclusion, the ownership principle lacks precision about who “owns” the concept. Adopting an emancipatory conceptualization of ownership, under which the ultimate beneficiaries should be the ones to determine priorities and strategies, eliminates the apparent contradiction and legitimizes support to marginalized groups even if their own governments disagree.
From adverse childhood experiences to adulthood job satisfaction: Mediating roles of posttraumatic beliefs and self‐evaluation
Authors: Kim Jaeyoung , Kim Isak , Zhou Kaiqi , Ji Wongeun 
Published: August 2024

AbstractThis study investigates the association between adverse childhood experiences (ACEs) and job satisfaction in adulthood, mediated by posttraumatic beliefs and core self‐evaluation (CSE). Based on the literature, we hypothesized that posttraumatic beliefs, potentially developed following ACEs, would have negative effects on individuals’ CSE and job satisfaction. Structural equation modeling of survey data from 384 employees with at least one ACE revealed that posttraumatic beliefs fully mediated the effect of ACEs on both job satisfaction and CSE. Furthermore, CSE was a partial mediator between posttraumatic beliefs and job satisfaction. These findings highlight the importance of adopting trauma‐informed approaches in employment counseling.
Progress in culture technology and active substance research on Nostoc sphaeroides Kützing
Authors: Li Fengcheng , Liu Runze , Qin Song , Deng Zhongyang , Li Wenjun 
Published: August 2024

AbstractNostoc sphaeroides Kützing is a freshwater edible cyanobacterium that is rich in active substances such as polysaccharides, proteins and lipids; it has a variety of pharmacological effects such as antioxidant, anti‐inflammatory, antitumor and cholesterol‐lowering effects; and is often used as a traditional Chinese medicine with many potential applications in food, cosmetics, medical diagnostics and disease treatment. However, to meet the needs of different fields, such as medicine, there is an urgent need for basic research and technological innovation in culture technology, extraction and preparation of active substances, and the pharmacological mechanism of N. sphaeroides. This paper reviews the pharmacological effects of N. sphaeroides active substances, discusses current culture techniques and methods for extracting active components, and outlines the challenges encountered in cultivating and industrializing N. sphaeroides while discussing future development trends. © 2024 Society of Chemical Industry.