bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food consumption of adults in Germany: results of the German National Nutrition Survey II based on diet history interviews
Authors: Heuer Thorsten , Krems Carolin , Moon Kilson , Brombach Christine , Hoffmann Ingrid 
Published: April 2015

The second German National Nutrition Survey (NVS II) aimed to evaluate food consumption and other aspects of nutritional behaviour of a representative sample of the German population, using a modular design with three different dietary assessment methods. To assess usual food consumption, 15 371 German speaking subjects 14–80 years of age completed a diet history interview between November 2005 and November 2006. With reference to the guidelines of the German Nutrition Society (DGE), NVS II observed that the German population did not eat enough foods of plant origin, especially vegetables and consumed too much of meat and meat products. While generally similar food consumption is observed in other European countries, consumption of bread, fruit juices/nectars and beer is higher in Germany. On average, men consumed two times more meat and soft drinks as well as six times more beer than women did, whereas the consumption of vegetables, fruit as well as herbal/fruit tea was higher in women. Older participants showed a lower consumption of meat, fruit juice/nectars, soft drinks and spirits as well as a higher consumption of fish, vegetables, fruit, and herbal/fruit tea than adolescents and younger adults did. There are also differences in food consumption with regard to socio-economic status (SES). Persons with higher SES consumed more vegetables, fruit, fish, water, coffee/tea and wine, while persons with lower SES consumed more meat and meat products, soft drinks and beer. In general, the food consumption of women, the elderly and the higher SES group tends to be closer to the official dietary guidelines in Germany.
Low BMI is inversely associated with arterial stiffness in Africans
Authors: Huisman Hugo Willem , Schutte Rudolph , Venter Herman Louwrens , van Rooyen Johannes Marthinus 
Published: April 2015

In low socio-economic status communities in South Africa, African men showed a low BMI. Data on the effect of low BMI on cardiovascular function are scant. The present study aimed to assess the associations between low BMI and markers of cardiovascular function such as pulse wave velocity (PWV) and blood pressure in Africans aged 35–65 years, with low socio-economic status. The study population (n 496) was stratified into a low-BMI group with BMI ≤ 20 kg/m2 and a normal-BMI group with BMI >20 kg/m2 and ≤ 25 kg/m2. Blood pressure (Omron HEM-757) and PWV (Complior SP; Artech-Medical) was determined. Africans with low BMI showed an increased arterial stiffness with significantly higher PWV compared with the normal-BMI group (men: P= 0·001; women: P= 0·026), which remained after adjustment. In men with low BMI, PWV correlated negatively with BMI before (r − 0·204; P= 0·012) and after (r − 0·200; P= 0·020) adjustment. Forward stepwise regression analyses indicated a negative association between PWV and BMI in African men. A J-curve was evident suggesting a detrimental effect of low BMI on cardiovascular function in Africans. A low BMI may contribute to the high prevalence of cardiovascular-related morbidity and mortality within a developing country.
Is there a time lag between the metamorphism and emplacement of plutons in the Axial Zone of the Pyrenees?
Authors: ESTEBAN J. J. , ARANGUREN A. , CUEVAS J. , HILARIO A. , TUBÍA J. M. , LARIONOV A. , SERGEEV S. 
Published: April 2015

AbstractDetailed petrographic and geochemical studies conducted on zircons from the Lys-Caillaouas pluton reveal their igneous and metamorphic affinities. The igneous zircons constrain the emplacement of the pluton to 300±2 Ma. By contrast, the metamorphic zircons yield an older age of 307±3 Ma, which probably dates the thermal peak of the HT/LP Variscan metamorphism. Therefore, a short time lag of c. 7 Ma emerges between the metamorphic climax and emplacement of the pluton in the Axial Zone (Pyrenees).
New Welfare, New Policies: Towards Preventive Worker-Directed Active Labour-Market Policies
Authors: van Berkel Rik , van der Aa Paul 
Published: April 2015

AbstractDebates about the new welfare, and the new social policies that go (or should go) with it, share an emphasis on risk-prevention strategies and pluralistic risk management. Focusing specifically on the risk of unemployment, this article discusses the case for so-called preventive worker-directed active labour market policies as part of the new welfare architecture. These policies are aimed at preventing unemployment and promoting labour-market transitions and employability. They involve responsibilities on the part of the state, social partners and employers. First, the case for these policies is elaborated by analysing the social investment, flexicurity and transitional labour-market literature. In this context, several issues related to the feasibility of the pluralistic management of preventing unemployment, as well as the possible impact of pluralistic risk management on dualisation, are discussed. Secondly, recent policy initiatives in the Netherlands are presented as an illustration of the incremental emergence of preventive worker-directed active labour-market policies. It is argued that although these policy initiatives were initially introduced as responses to the crisis, they may eventually turn out to reflect a more fundamental reorientation in managing and dealing with the risks of unemployment. The conclusion critically reflects and argues that pluralistic risk management may exacerbate, rather than mitigate, the insecurities of flexible and non-standard workers.
Citizen Carer: Carer's Allowance and Conceptualisations of UK Citizenship
Authors: SINGLETON BENEDICT E. , FRY GARY 
Published: April 2015

AbstractCarers make a considerable contribution to the health and social care of sick or disabled people, reducing the strain on health and social care systems. This has been recognised through support mechanisms, including (in the UK) a payment for caring (Carer's Allowance – CA). This article draws upon data from a study of carers receiving CA. Utilising a citizenship perspective, it examines respondents’ perspectives on their role in the UK and shows how CA provides not only financial support but also contributes to normative conceptualisations of citizenship. The data highlight the primacy of paid work in UK citizenship, as well as the stigma associated with receiving welfare benefits. The article concludes by claiming that changes to the UK benefit system need to take into account a ‘recognition’ aspect, reformulating what is considered a worthwhile contribution to society.
Reading skill and exposure to orthography influence speech production
Authors: SALETTA MEREDITH , GOFFMAN LISA , BRENTARI DIANE 
Published: April 2015

ABSTRACTOrthographic experience during the acquisition of novel words may influence production processing in proficient readers. Previous work indicates interactivity among lexical, phonological, and articulatory processing; we hypothesized that experience with orthography can also influence phonological processing. Phonetic accuracy and articulatory stability were measured as adult, proficient readers repeated and read aloud nonwords, presented in auditory or written modalities and with variations in orthographic neighborhood density. Accuracy increased when participants had read the nonwords earlier in the session, but not when they had only heard them. Articulatory stability increased with practice, regardless of whether nonwords were read or heard. Word attack skills, but not reading comprehension, predicted articulatory stability. Findings indicate that kinematic and phonetic accuracy analyses provide insight into how orthography influences implicit language processing.
2013 multistate outbreaks ofCyclospora cayetanensisinfections associated with fresh produce: focus on the Texas investigations
Authors: ABANYIE F. , HARVEY R. R. , HARRIS J. R. , WIEGAND R. E. , GAUL L. , DESVIGNES-KENDRICK M. , IRVIN K. , WILLIAMS I. , HALL R. L. , HERWALDT B. , GRAY E. B. , QVARNSTROM Y. , WISE M. E. , CANTU V. , CANTEY P. T. , BOSCH S. , DA SILVA A. J. , FIELDS A. , BISHOP H. , WELLMAN A. , BEAL J. , WILSON N. , FIORE A. E. , TAUXE R. , LANCE S. , SLUTSKER L. , PARISE M. ,   the Multistate Cyclosporiasis Outbreak Investigation Team
Published: April 2015

SUMMARYThe 2013 multistate outbreaks contributed to the largest annual number of reported US cases of cyclosporiasis since 1997. In this paper we focus on investigations in Texas. We defined an outbreak-associated case as laboratory-confirmed cyclosporiasis in a person with illness onset between 1 June and 31 August 2013, with no history of international travel in the previous 14 days. Epidemiological, environmental, and traceback investigations were conducted. Of the 631 cases reported in the multistate outbreaks, Texas reported the greatest number of cases, 270 (43%). More than 70 clusters were identified in Texas, four of which were further investigated. One restaurant-associated cluster of 25 case-patients was selected for a case-control study. Consumption of cilantro was most strongly associated with illness on meal date-matched analysis (matched odds ratio 19·8, 95% confidence interval 4·0–∞). All case-patients in the other three clusters investigated also ate cilantro. Traceback investigations converged on three suppliers in Puebla, Mexico. Cilantro was the vehicle of infection in the four clusters investigated; the temporal association of these clusters with the large overall increase in cyclosporiasis cases in Texas suggests cilantro was the vehicle of infection for many other cases. However, the paucity of epidemiological and traceback information does not allow for a conclusive determination; moreover, molecular epidemiological tools for cyclosporiasis that could provide more definitive linkage between case clusters are needed.
Urban park-related risks forGiardiaspp. infection in dogs
Authors: SMITH A. F. , ROCK M. , NEUMANN N. , MASSOLO A. 
Published: April 2015

SUMMARYGiardiaspp. is a common gastrointestinal (GI) parasite of multiple host species, including dogs and humans, with the potential for zoonotic transmission. The risk of GI parasitism in dogs (includingGiardiaspp.) may increase with park use in urban areas. This study aimed to (1) determine whether park attendance is a risk factor forGiardiaspp. infection in dogs and (2) characterize the behavioural and demographic risk factors forGiardiaspp. infection in park-attending and non-park-attending dogs. From August to September 2012, a total of 1293 dog owners completed a survey and 860 corresponding dog faecal samples were collected. Dog faeces were screened forGiardiaspp. using a direct immunofluorescence assay and associations assessed among behaviours, demographics, andGiardiaspp. infection. Main results included off-leash and swimming frequencies within parks as significantly positively associated withGiardiaspp. infection in dogs. Dog-owner age was negatively associated with off-leash and swimming frequencies in parks. The results suggest some recreational behaviours in parks and certain demographics are risk factors for parasitism in pet dogs.
Adult encephalitis surveillance: experiences from an Australian prospective sentinel site study
Authors: EASTWOOD K. , PATERSON B. J. , LEVI C. , GIVNEY R. , LOEWENTHAL M. , DE MALMANCHE T. , LAI K. , GRANEROD J. , DURRHEIM D. N. 
Published: April 2015

SUMMARYFew countries routinely collect comprehensive encephalitis data, yet understanding the epidemiology of this condition has value for clinical management, detecting novel and emerging pathogens, and guiding timely public health interventions. When this study was conducted there was no standardized diagnostic algorithm to aid identification of encephalitis or systematic surveillance for adult encephalitis. In July 2012 we tested three pragmatic surveillance options aimed at identifying possible adult encephalitis cases admitted to a major Australian hospital: hospital admissions searches, clinician notifications and laboratory test alerts (CSF herpes simplex virus requests). Eligible cases underwent structured laboratory investigation and a specialist panel arbitrated on the final diagnosis. One hundred and thirteen patients were initially recruited into the 10-month study; 20/113 (18%) met the study case definition, seven were diagnosed with infectious or immune-mediated encephalitis and the remainder were assigned alternative diagnoses. The laboratory alert identified 90% (102/113) of recruited cases including six of the seven cases of confirmed encephalitis suggesting that this may be a practical data source for case ascertainment. The application of a standardized diagnostic algorithm and specialist review by an expert clinical panel aided diagnosis of patients with encephalitis.
When will Low-Contrast Features be Visible in a STEM X-Ray Spectrum Image?
Authors: Parish Chad M. 
Published: April 2015

AbstractWhen will a small or low-contrast feature, such as an embedded second-phase particle, be visible in a scanning transmission electron microscopy (STEM) X-ray map? This work illustrates a computationally inexpensive method to simulate X-ray maps and spectrum images (SIs), based upon the equations of X-ray generation and detection. To particularize the general procedure, an example of nanostructured ferritic alloy (NFA) containing nm-sized Y2Ti2O7 embedded precipitates in ferritic stainless steel matrix is chosen. The proposed model produces physically appearing simulated SI data sets, which can either be reduced to X-ray dot maps or analyzed via multivariate statistical analysis. Comparison to NFA X-ray maps acquired using three different STEM instruments match the generated simulations quite well, despite the large number of simplifying assumptions used. A figure of merit of electron dose multiplied by X-ray collection solid angle is proposed to compare feature detectability from one data set (simulated or experimental) to another. The proposed method can scope experiments that are feasible under specific analysis conditions on a given microscope. Future applications, such as spallation proton–neutron irradiations, core-shell nanoparticles, or dopants in polycrystalline photovoltaic solar cells, are proposed.
EphB4 forward signalling regulates lymphatic valve development
Authors: Zhang Gu , Brady John , Liang Wei-Ching , Wu Yan , Henkemeyer Mark , Yan Minhong 
Published: April 2015

AbstractBidirectional signalling is regarded as a notable hallmark of the Eph-ephrin signalling system: Eph-dependent forward signalling in Eph-expressing cells and ephrin-dependent reverse signalling in Ephrin-expressing cells. The notion of ephrin-dependent reverse signalling derives from genetic experiments utilizing mice carrying mutations in the intracellular region of ephrinBs. Here we show that EphB4-dependent forward signalling regulates lymphatic valve development, a process previously thought to be regulated by ephrinB2-dependent reverse signalling. We develop antibodies that selectively target EphB4 and ephrinB2. We find that mice bearing genetically altered cytoplasmic region of ephrinB2 have significantly altered EphB4-dependent forward signalling. Selective inhibition of EphB4 using a functional blocking antibody results in defective lymphatic valve development. Furthermore, a chemical genetic approach is used to unequivocally show that the kinase activity of EphB4 is essential for lymphatic valve development.
Ultra-sensitive all-fibre photothermal spectroscopy with large dynamic range
Authors: Jin Wei , Cao Yingchun , Yang Fan , Ho Hoi Lut 
Published: April 2015

AbstractPhotothermal interferometry is an ultra-sensitive spectroscopic means for trace chemical detection in gas- and liquid-phase materials. Previous photothermal interferometry systems used free-space optics and have limitations in efficiency of light–matter interaction, size and optical alignment, and integration into photonic circuits. Here we exploit photothermal-induced phase change in a gas-filled hollow-core photonic bandgap fibre, and demonstrate an all-fibre acetylene gas sensor with a noise equivalent concentration of 2 p.p.b. (2.3 × 10−9 cm−1 in absorption coefficient) and an unprecedented dynamic range of nearly six orders of magnitude. The realization of photothermal interferometry with low-cost near infrared semiconductor lasers and fibre-based technology allows a class of optical sensors with compact size, ultra sensitivity and selectivity, applicability to harsh environment, and capability for remote and multiplexed multi-point detection and distributed sensing.
Regulation of systemic energy homeostasis by serotonin in adipose tissues
Authors: Oh Chang-Myung , Namkung Jun , Go Younghoon , Shong Ko Eun , Kim Kyuho , Kim Hyeongseok , Park Bo-Yoon , Lee Ho Won , Jeon Yong Hyun , Song Junghan , Shong Minho , Yadav Vijay K. , Karsenty Gerard , Kajimura Shingo , Lee In-Kyu , Park Sangkyu , Kim Hail 
Published: April 2015

AbstractCentral serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.
Logging cuts the functional importance of invertebrates in tropical rainforest
Authors: Ewers Robert M. , Boyle Michael J. W. , Gleave Rosalind A. , Plowman Nichola S. , Benedick Suzan , Bernard Henry , Bishop Tom R. , Bakhtiar Effendi Y. , Chey Vun Khen , Chung Arthur Y. C. , Davies Richard G. , Edwards David P. , Eggleton Paul , Fayle Tom M. , Hardwick Stephen R. , Homathevi Rahman , Kitching Roger L. , Khoo Min Sheng , Luke Sarah H. , March Joshua J. , Nilus Reuben , Pfeifer Marion , Rao Sri V. , Sharp Adam C. , Snaddon Jake L. , Stork Nigel E. , Struebig Matthew J. , Wearn Oliver R. , Yusah Kalsum M. , Turner Edgar C. 
Published: April 2015

AbstractInvertebrates are dominant species in primary tropical rainforests, where their abundance and diversity contributes to the functioning and resilience of these globally important ecosystems. However, more than one-third of tropical forests have been logged, with dramatic impacts on rainforest biodiversity that may disrupt key ecosystem processes. We find that the contribution of invertebrates to three ecosystem processes operating at three trophic levels (litter decomposition, seed predation and removal, and invertebrate predation) is reduced by up to one-half following logging. These changes are associated with decreased abundance of key functional groups of termites, ants, beetles and earthworms, and an increase in the abundance of small mammals, amphibians and insectivorous birds in logged relative to primary forest. Our results suggest that ecosystem processes themselves have considerable resilience to logging, but the consistent decline of invertebrate functional importance is indicative of a human-induced shift in how these ecological processes operate in tropical rainforests.
RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1
Authors: Ponnusamy K , Kohrs N , Ptasinska A , Assi S A , Herold T , Hiddemann W , Lausen J , Bonifer C , Henschler R , Wichmann C 
Published: April 2015

AbstractRUNX1/ETO (RE), the t(8;21)-derived leukemic transcription factor associated with acute myeloid leukemia (AML) development, deregulates genes involved in differentiation, self-renewal and proliferation. In addition, these cells show differences in cellular adhesion behavior whose molecular basis is not well understood. Here, we demonstrate that RE epigenetically silences the gene encoding P-Selectin Glycoprotein Ligand-1 (PSGL-1) and downregulates PSGL-1 expression in human CD34+ and murine lin− hematopoietic progenitor cells. Levels of PSGL-1 inversely and dose-dependently correlate with RE oncogene levels. However, a DNA-binding defective mutant fails to downregulate PSGL-1. We show by ChIP experiments that the PSGL-1 promoter is a direct target of RE and binding is accompanied by high levels of the repressive chromatin mark histone H3K27me3. In t(8;21)+ Kasumi-1 cells, PSGL-1 expression is completely restored at both the mRNA and cell surface protein levels following RE downregulation with short hairpin RNA (shRNA) or RE inhibition with tetramerization-blocking peptides, and at the promoter H3K27me3 is replaced by the activating chromatin mark H3K9ac as well as by RNA polymerase II. Upregulation of PSGL-1 restores the binding of cells to P- and E-selectin and re-establishes myeloid-specific cellular adhesion while it fails to bind to lymphocyte-specific L-selectin. Overall, our data suggest that the RE oncoprotein epigenetically represses PSGL-1 via binding to its promoter region and thus affects the adhesive behavior of t(8;21)+ AML cells.
A Dynamic View of ATP-coupled Functioning Cycle of Hsp90 N-terminal Domain
Authors: Zhang Huaqun , Zhou Chen , Chen Wuyan , Xu Yechun , Shi Yanhong , Wen Yi , Zhang Naixia 
Published: April 2015

AbstractHeat-shock protein 90 (Hsp90) is one of the most important chaperones involved in multiple cellular processes. The chaperoning function of Hsp90 is intimately coupled to the ATPase activity presented by its N-terminal domain. However, the molecular mechanism for the ATP-dependent working cycle of Hsp90 is still not fully understood. In this study, we use NMR techniques to investigate the structural characteristics and dynamic behaviors of Hsp90 N-terminal domain in its free and AMPPCP (ATP analogue) or ADP-bound states. We demonstrated that although AMPPCP and ADP bind to almost the same region of Hsp90, significantly different effects on the dynamics behaviors of the key structural elements were observed. AMPPCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117–A141) within the lid segment (A111–G135) and around region, while ADP binding keeps Hsp90 staying at the inactive state by increasing the conformational rigidity of the lid segment and around region. Based on our findings, a dynamic working model for the ATP-dependent functioning cycle of Hsp90 was proposed.