bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Epitope Against Omicron Variant of SARS-CoV-2:
In Silico Vaccine Design Approach
Authors: Kaur Manpreet , Ram Gobind 
Published: July 2024

Background::
SARS-CoV-2, which causes COVID-19, resulted in a global pandemic, and
there were millions of confirmed cases and deaths worldwide. The vaccines were developed and
distributed to help control the spread of the virus. The numbers and information related to the
COVID-19 pandemic have likely evolved. Therefore, rapid immunological epitope identification
would be a useful screening technique for vaccine candidates.

Objective::
The aim of this study is to anticipate the protective epitopes for vaccine development
using bioinformatics methods and resources

Methodology::
The SARS-CoV-2 genome and protein sequences were retrieved. Furthermore, using
the ABCpred server, sequential B-cell epitope analysis was carried out. The Ellipro algorithm was
used to forecast discontinuous B-cell epitopes. Moreover, by utilising the NetCTL server, a sequential
T-cell epitope analysis was carried out. Furthermore, the 3D structure of the peptide was created
using the PEP-FOLD3 server, and the 3D structure of the HLA molecule was identified using the
homology modelling tool. The molecular docking was performed by AutoDock Vina.

Results::
There were 20 B-cell epitopes altogether, of which 11 are highly antigenic. After assessing
the antigenicity and toxicity of each resultant epitope, it was determined that the epitope
SVLYNLAPFFTFKCYG is highly antigenic. Then, out of the 6 T-cell epitopes we had found,
"RSYSFRPTY" was chosen as the epitope most suited for further research. Consequently, 72.42% of
the population is covered overall. The structure that was generated was refined and energyminimized.
RSYSFRPTY's binding affinity to the groove of HLA-B*15:01 was determined by docking
study to be -7.5 kcal/mol. PyMOL's visualisation of the docking result for predicting binding
sites.

Conclusion::
The final B-cell and T-cell epitopes are “SVLYNLAPFFTFKCYG” and
“RSYSFRPTY” in terms of antigenicity score and nonallergenic and nontoxic qualities. An in Silico
study indicated that our hypothesised T cell epitope “RSYSFRPTY” had a greater affinity for binding
with its receptor, which might elicit an immune response against the omicron variant.
PERUBAHAN TRADISI MOMBOLASUAKO (KAWIN LARI) PADA PERNIKAHAN SUKU TOLAKI DI DESA SANGGULA
Authors: Sarnawati Sarnawati , Pinasti V. Indah Sri 
Published: July 2024

Penelitian ini bertujuan untuk: 1) mengetahui bagaimana perubahan yang terjadi dalam pernikahan suku Tolaki melalui tradisi mombolasuako¸ 2) untuk mengetahui dampak perubahan tradisi mombolasuako bagi suku Tolaki. Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Pemilihan informan dalam penelitian ini menggunakan purposive sampling dengan kriteria tertentu. Informan penelitian terdiri atas informan kunci (tolea, puutobu, ketua adat, kepala desa) dan informan biasa (pelaku mombolasuako). Validitas data dalam penelitian ini menggunakan metode triangulasi sumber. Proses analisis data dalam penelitian ini menggunakan analisis model interaktif Miles dan Huberman, mulai dari kondensasi data (selecting, focusing, abstracting, sampling dan transformasi), Penyajian data, dan penarikan kesimpulan. Hasi penelitian ini menunjukkan bahwa perubahan yang terjadi dalam tradisi mombolasuako meliputi 1) mombolasuako mulai tergantikan dengan mowawo niwule dan melanggahako. 2) pemaknaan yang berbeda terhadap mombolasuako, 3) aturan adat yang berlaku dalam prosesi mombolasuako dinominalkan. Proses perubahan dalam tradisi mombolasuako awalnya dilihat sebagai tindakan tradisional, namun saat ini dilihat sebagai tindakan rasionalitas nilai. Hal ini disebabkan oleh faktor internal (kesadaran masyarakat terhadap hukum adat, rasionalitas masyarakat dalam bertindak) dan eksternal (ekonomi). Dampak yang diberikan yaitu pertama dampak positif adalah menurunnya jumlah kasus mombolasuako, efisiensi waktu, masyarakat mulai berpikir terbuka terhadap perubahan. Kedua dampak negatif yaitu nilai simbolik tradisi mombolasuako mengalami reduksi, masyarakat mulai cenderung berpikir instan. Ketiga dampak bagi suku lain yang ada di Desa Sanggula yaitu terjadinya pembauran budaya.
DAMPAK KEHIDUPAN SOSIAL EKONOMI MASYARAKAT PETANI TAMBAK DENGAN ADANYA PEMBANGUNAN YIA KABUPATEN KULON PROGO
Authors: Yoga Yudi Noviantoro Dwi , Pinasti V. Indah Sri 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui dampak sosial dan ekonomi masyarakat petani tambak yang terjadi karena pembangunan bandara YIA di Kecamatan Temon , Kabupaten Kulon Progo serta bagaimana cara mengatasi damapak sosial dan ekonomi bagai masyarakat petani tambak yang terkena dampak. Penelitian ini menggunakan metode penelitian kualitatif. Subyek penelitian ini adalah pemilik lahan tambak, pekerja lahan tambak, dan masyarakat sekitar yang terdampak. Penelitian ini menggunakan teknik purposive sampling. Teknik pengumpulan data berupa observasi, wawancara, dan Dokumentasi. Validitas data menggunakan triangulasi sumber dan triangulasi teknik. Analisis data menggunakan Miles dan Huberman. Hasil penelitian menunjukkan bahwa adanya dampak sosial ekonomi yang berifat negatif pada masyarakat petani tambak di kulon progo. Dampak sosial berupa: interaksi sosial pada masyarakat petani tambak menjadi berkurang, lahan petani tambak hilang karena mengalami penggusuran lahan tambak sehingga kehilangan mata pencaharian. Dampak Ekonomi berupa: Petani tambak hanya sebagian saja yang mengalami ganti rugi, mematikan peluang usaha yang mereka miliki karena penggusuran lahan tambak, pengahasilannya cenderung berkurang, menghambat pertumbuhan ekonomi masyarakat petani tambak. Cara mengatasi dampak sosial berupa memberikan penyuluhan kepada masyarakat, dan mobilitas masyarakat petani tambak. Cara mengatasi dampak ekonomi mendorong untuk berwirausaha lain, dan meningkatkan tingkat pendapatan.
PERAN PIHAK KETIGA PADA KELUARGA DENGAN POLA KARIR GANDA (STUDI KASUS WANITA PABRIKAN DI KABUPATEN PURBALINGGA)
Authors: Aryo Ambaruny , Hidayah Nur 
Published: July 2024

Pola karir ganda yang dialami wanita pabrikan di Purbalingga memunculkan problematika dan perubahan pola manajerial pada kehidupan keluarga. Pihak ketigakemudian muncul untuk membantu menyelesaikan pekerjaan rumah tangga yangterbengkalai. Penelitian ini bertujuan untuk: 1) mengetahui siapa saja yang termasuk pihakketiga pada keluarga dengan pola karir ganda; 2) mengetahui peran pihak ketiga padakeluarga wanita pabrikan. Penelitian ini menggunakan metode kualitatif, dengan informanwanita pabrikan di Kabupaten Purbalingga yang mengalami pola karir ganda. Informan dipilih dengan teknik sampel snowball. Metode pengumpulan data yang digunakan meliputiobservasi, wawancara, dan dokumentasi. Teknik analisis data menggunakan model analisisinteraktif yang meliputi tahap pengumpulan data, reduksi data, penyajian data, dan penarikankesimpulan. Keabsahan data atau validitas data diperiksa dengan menggunakan triangulasidata. Hasil penelitian menunjukan bahwa 1) Pihak-pihak yang dijadikan pihak ketiga olehwanita pabrikan di Purbalingga dapat diklasifikasikan menjadi dua yaitu yang berasal darisanak saudara (orang tua/mertua atau saudara) dan yang bukan berasal dari sanak saudara(tetangga atau teman sejawat); 2) Peran pihak ketiga yang berasal dari sanak saudara meliputipengasuhan anak, membersihkan rumah, memasak, mencuci dan tidak terbatas waktu dalammengerjakannya. Sedangkan peran pihak ketiga yang bukan berasal dari sanak saudara hanyadalam pengasuhan anak dan dengan waktu yang terbatas yaitu selama wanita pabrikanbekerja. Kata Kunci: Peran Pihak Ketiga, Pola Karir Ganda, Wanita Pabrikan
Enhancing Type 2 Diabetes Treatment Decisions With Interpretable Machine Learning Models for Predicting Hemoglobin A1c Changes: Machine Learning Model Development
Authors: Kurasawa Hisashi , Waki Kayo , Seki Tomohisa , Chiba Akihiro , Fujino Akinori , Hayashi Katsuyoshi , Nakahara Eri , Haga Tsuneyuki , Noguchi Takashi , Ohe Kazuhiko 
Published: July 2024

Background
Type 2 diabetes (T2D) is a significant global health challenge. Physicians need to assess whether future glycemic control will be poor on the current trajectory of usual care and usual-care treatment intensifications so that they can consider taking extra treatment measures to prevent poor outcomes. Predicting poor glycemic control from trends in hemoglobin A1c (HbA1c) levels is difficult due to the influence of seasonal fluctuations and other factors.

Objective
We sought to develop a model that accurately predicts poor glycemic control among patients with T2D receiving usual care.

Methods
Our machine learning model predicts poor glycemic control (HbA1c≥8%) using the transformer architecture, incorporating an attention mechanism to process irregularly spaced HbA1c time series and quantify temporal relationships of past HbA1c levels at each time point. We assessed the model using HbA1c levels from 7787 patients with T2D seeing specialist physicians at the University of Tokyo Hospital. The training data include instances of poor glycemic control occurring during usual care with usual-care treatment intensifications. We compared prediction accuracy, assessed with the area under the receiver operating characteristic curve, the area under the precision-recall curve, and the accuracy rate, to that of LightGBM.

Results
The area under the receiver operating characteristic curve, the area under the precision-recall curve, and the accuracy rate (95% confidence limits) of the proposed model were 0.925 (95% CI 0.923-0.928), 0.864 (95% CI 0.852-0.875), and 0.864 (95% CI 0.86-0.869), respectively. The proposed model achieved high prediction accuracy comparable to or surpassing LightGBM’s performance. The model prioritized the most recent HbA1c levels for predictions. Older HbA1c levels in patients with poor glycemic control were slightly more influential in predictions compared to patients with good glycemic control.

Conclusions
The proposed model accurately predicts poor glycemic control for patients with T2D receiving usual care, including patients receiving usual-care treatment intensifications, allowing physicians to identify cases warranting extraordinary treatment intensifications. If used by a nonspecialist, the model’s indication of likely future poor glycemic control may warrant a referral to a specialist. Future efforts could incorporate diverse and large-scale clinical data for improved accuracy.
Technology Use for Home-Based Stroke Rehabilitation in Switzerland From the Perspectives of Persons Living With Stroke, Informal Caregivers, and Therapists: Qualitative Interview and Focus Group Study
Authors: Sauerzopf Lena , Luft Andreas , Maeusli Valeria , Klamroth-Marganska Verena , Sy Michael , Spiess Martina Rebekka 
Published: July 2024

Background
Stroke is a leading cause for long-term disability, requiring both inpatient and outpatient rehabilitation and self-training in the home environment. Technology-based tools are gradually gaining acceptance as additional and suitable options for extending the rehabilitation process. While the experiences of persons living with stroke, therapists, and informal caregivers with respect to technology use have already been investigated in other countries, this topic is underexplored in the Swiss context.

Objective
We aimed to explore the experiences and needs of persons living with stroke, informal caregivers, and therapists in using technology-based tools in a home environment for stroke rehabilitation in Switzerland.

Methods
This study followed a qualitative descriptive methodology, including semistructured interviews and focus group discussions. We applied a deductive template analysis alongside the accessibility, adaptability, accountability, and engagement framework to analyze the qualitative data sets for technology-assisted solutions for poststroke rehabilitation.

Results
We collected the experiences and needs of persons living with stroke (7/23, 30%), informal caregivers (4/23, 17%), and therapists (occupational and physical therapists; 12/23, 52%). The 4 categories we used to organize the analysis and results were accessibility to quality rehabilitation, adaptability to patient differences, accountability or compliance with rehabilitation, and engagement with rehabilitation. Persons living with stroke stated that they use various tools within their rehabilitation process depending on their specific needs. They felt that there is a plethora of tools available but sometimes felt overwhelmed with the selection process. Informal caregivers indicated that they generally felt underserved and insufficiently informed throughout the rehabilitation process. They reported that they use technology-based tools to support their relatives affected by stroke in becoming more independent. Therapists appreciate the numerous possible applications of technology-based tools in rehabilitation. At the same time, however, they express dissatisfaction with the lack of clarity in Switzerland regarding cost coverage, recommendations, and training opportunities.

Conclusions
Persons living with stroke, informal caregivers, and therapists in Switzerland reported varied and unique experiences and needs with the use of technology-based tools in outpatient stroke rehabilitation. Written recommendations, the assumption of financial costs, and the provision of information and education could foster increased confidence in the use of technology-based tools for patients and therapists.
Deteksi Molekuler Bakteri Liberobacter Asiaticum Penyebab Penyakit Citrus Vein Phloem Degeneration (CVPD) Pada Tanaman Jeruk Siam (Citrus Nobilis)
Authors: Marhaeni Ketut Srie , I Putu Parwata  
Published: July 2024

Citrus Vein Phloem Degeneration (CVPD) merupakan penyakit yang sering menyerang tanaman jeruk. Penyebab penyakit CVPD yang disebut juga citrus greening atau huang longbing adalah bakteri Liberobacter yang termasuk dalam subdivisi Protobacteria. Bakteri Liberobacter hidup pada floem tanaman jeruk dan menimbulkan gejala yang khas, namun bakteri tersebut tidak dapat dibiakkan pada media buatan. Tujuan dari penelitian ini adalah untuk mengidentifikasi gejala secara morfologi terhadap tanaman jeruk yang menunjukkan gejala terserang penyakit CVPD dan tanaman jeruk yang tidak menunjukkan gejala. Peneltian ini tergolong ke dalam penelitian eksperimental laboratorium. Subjek penelitian adalah tanaman jeruk siam yang menunjukkan gejala serangan CVPD dan yang tidak menunjukkan gejala serangan yang diambil di dua lokasi yang berbeda. Metode pengumpulan data yang digunakan dalam penelitian ini adalah pengambilan sampel daun jeruk dari dua lokasi berbeda, yaitu dari tanaman jeruk yang nampak sehat dan yang menunjukkan gejala penyakit CVPD. Instrumen yang digunakan meliputi berbagai alat laboratorium seperti mesin PCR, alat elektroforesis, centrifuge, UV transilluminator, dan lainnya yang digunakan untuk analisis DNA. Setelah data dikumpulkan kemudian dianalisis dengan teknik isolasi DNA dan amplifikasi DNA menggunakan teknik PCR. Hasil penelitian menunjukkan bahwa, deteksi menggunakan PCR menunjukkan keberadaan bakteri Liberobacter asiaticum pada daun jeruk Siam bergejala dan tidak bergejala CVPD, dengan pita DNA teramplifikasi pada 1160 bp. Sehingga, dapat disimpulkan bahwa, daun jeruk Siam yang bergejala dan tidak bergejala CVPD sama-sama mengandung bakteri Liberobacter asiaticum, yang terdeteksi melalui PCR dengan pita DNA pada 1160 bp. Maka dari itu, memungkinkan tindakan pencegahan lebih awal dalam pengelolaan penyakit jeruk.
Dormitory Management as an Effort to Improve the Islamic Character of Students Diniyyah Pasia Modern Islamic Boarding School
Authors: Zakiya Nabila , M Sufyarma , Sulastri Sulastri 
Published: July 2024

In the management of an organization or educational institution, Islamic boarding schools are educational institutions that have their characteristics. The hallmark of Islamic boarding schools is the existence of a hut as a temporary residence for female students also called Santriwati has become a hereditary tradition that distinguishes Islamic boarding schools from other education systems. The dormitory for Islamic boarding school is very important because it is a shelter for female students (Santriwati) as well as for studying religious sciences, studying classical books, and imitating the attitudes of Kyai, Ustadzah, and Musyrifah who are in the dormitory. This is by the purpose of education in Islamic boarding schools, namely that students can have good and noble Islamic characters. To achieve the goals of education in Islamic boarding schools, Islamic boarding schools need to manage Islamic boarding schools well so that they can face the currents of globalization. As a place for the cadre of scholars, the development of methodologies and knowledge, an ideal place for the transformation, motivation, and innovation of female students (Santriwati) and Islamic boarding schools are expected to be able to contribute to the formation of the student's Islamic character. In this study, the researcher used a qualitative approach, while the method used was a case study method. The findings obtained from the results of processing and analyzing qualitative data with in-depth observation and interview techniques on the focus of the research "Management of Dormitory as an Effort to Improve the Islamic Character of Students in Diniyyah Pasia Modern Islamic Boarding Schools". In general, the role of the dormitory manager or Musyrifah room carrying out its function as a hostel manager from planning, organizing, implementing, and controlling can improve the Islamic character of female students (Santriwati) both at the stage of moral knowing, moral loving and moral doing.
Education in Management of Siak Woven Fabrics by the DEKRANASDA
Authors: Fitri Aulia Annisa , Efi Agusti 
Published: July 2024

This study aims to determine the management of the Siak typical cloth carried out or managed by the Regional National Crafts Council (DEKRANASDA) in Siak Regency, Riau Province. The research used a qualitative approach and was conducted at DEKRANASDA in Siak Regency. Primary data were obtained from interviews with three weavers working in the DEKRANASDA Siak Regency, and interviews with two administrators from Dekranasda. The data obtained are further analyzed qualitatively. The Siak Woven Cloth Management Program is carried out by the DEKRANASDA by implementing or providing training for craftsmen who want to learn and carry out activities and events that can promote these crafts and cultural heritage to the community both inside and outside the Siak regency. the management carried out by the management for weavers who work in the DEKRANASDA Siak Regency is to provide raw materials, and equipment for weavers, and make new motifs, innovations, and color modifications but do not eliminate the characteristics of the Weaving itself and accommodate woven fabrics woven by independent or private craftsmen, promote MSME products through events and activities either directly as well as social media, marketing and paying for woven products according to the amount of woven fabric to craftsmen, providing facilities to weaving craftsmen, and making new products from Siak Weaving fabrics.
Collaborative Governance dalam Penyelenggaraan Transportasi Sektor Darat di Provinsi Sulawesi Tenggara
Authors: Satyadharma Maudhy , Susanti Neni 
Published: July 2024

Penyelenggaraan sektor transportasi dengan berbagai permasalahan yang ada sangat membutuhkan penerapan Collaborative Governance. Penelitian ini dilakukan untuk menganalisis penerapan Collaborative Governance dalam penyelenggaraan transportasi khususnya di sektor darat Provinsi Sulawesi Tenggara Penelitian ini menggunakan jenis penelitian dengan pendekatan kualitatif dan penelitian telah dilaksanakan dari Bulan Oktober-Desember 2023. Hasil penelitian menyimpulkan dalam penyelenggaraan transportasi sektor darat di Provinsi Sulawesi Tenggara diawali oleh proses dialog tatap muka diantara para stakeholder, lalu akan melahirkan kepercayaan yang terbangun diantara para stakeholder. Selain itu akan terbangun komitmen pada proses kolaborasi yang dilahirkan dalam bentuk Kesepakatan bersama (MoU) diantara para stakeholder. Rangkaian itu lalu dilanjutkan oleh pemahaman bersama oleh instansi terkait serta akan menimbulkan dampak sementara yang diharapkan mampu mendorong aturan penyelenggaraan angkutan umum baik angkutan penumpang (AKDP) dan Angkutan Barang serta aturan berlalu lintas di jalan raya lebih dipatuhi sehingga akan tercipta transportasi yang aman, nyaman, selamat dan berkelanjutan di Provinsi Sulawesi Tenggara.
Strategi Perempuan Pemulung Batubara dalam Pemenuhan Ekonomi Keluarga di Kota Sawahlunto
Authors: Khairunniza Mirza , Hidayat Muhammad 
Published: July 2024

Penelitian ini dilatar belakangi oleh kendala dalam pemenuhan ekonomi yang dihadapi oleh perempuan pemulung batubara. Penelitian ini penting untuk dilakukan karena dalam pemenuhan kebutuhan ekonomi keluarga tidak cukup sehingga perempuan pemulung batubara berperan dalam pemenuhan ekonomi keluarga. Tujuan penelitian ini yaitu menjelaskan strategi perempuan pemulung batubabara dalam mengatasi pendapatan keluarga di daerah pertambangan Perambahan Kota Sawahlunto Sumatera Barat. Teori yang digunakan yaitu teori tindakan aktor oleh Max Weber. Penelitian ini menggunakan pendekatan kualitatif dengan jenis studi kasus. Teknik pemilihan informan menggunakan teknik purposive sampling berjumlah 7 informan, dengan kriteria pemulung perempuan batubara yang dikategorikan sudah bekerluarga. Teknik pengumpulan data dilaksanakan dengan cara observasi dimana peneliti mengamati lingkungan tempat kerja dan kegiatan pemulung batubara serta alat yang digunakan dalam mendukung pekerjaannya. Wawancara mendalam peneliti menanyakan hal-hal terkait strategi yang dilakukan perempuan pemulung batubara dalam pemenuhan kebutuhan hidup. Studi dokumentasi dengan mengambil foto sejarah Kota sawahlunto dari buku sejarah sebagai pelengkap. Teknik analisis data menggunakan model analisis Miles dan Huberman (Pengumpulan data, reduksi data, penyajian data, dan verifikasi atau penarikan kesimpulan). Hasil penelitian menunjukkan strategi yang dilakukan perempuan pemulung dalam pemenuhan ekonomi keluarga yaitu pertama, Menyisihkan sebagian uang untuk ditabung, Kedua Mengkuti arisan bulanan, Ketiga Musyawarah dengan suami apabila ada kebutuhan mendadak. Keempat, Bekerja sampingan lain selain menjadi pemulung batubara.
Consumer engagement in sustainable consumption: do demographics matter?
Authors: Čapienė Aistė , Rūtelionė Aušra , Adamonienė Rūta 
Published: July 2024

Abstract
This study investigates the relationship between internal and external factors of pro-environmental and pro-social engagement, sustainable consumption behaviour and personal characteristics such as age, gender, financial situation and level of education in the Lithuanian population. A quantitative method was used to collect data from 904 respondents in Lithuania. The study results suggest that women are more concerned about pro-environmental and pro-social issues. In addition, pro-environmental commitment, biospheric values, personal norms and perceived responsibility were important for women. Meanwhile, egoistic values, self-efficacy, social norms, biospheric values, and attachment to place were identified as more important for men. The results reveal that older age increasingly correlates with a stronger expression of place attachment, egoistic values and self-efficacy, pro-environmental and pro-social engagement, and sustainable consumption behaviour. The results of this empirical study allow for identifying the determinants that have the most significant impact on men and women or different age groups. Knowledge of factors that significantly impact pro-environmental and pro-social engagement, which promotes sustainable consumption behaviour as a mediator, can allow policymakers, community representatives or leaders to organise social campaigns and/or provide guidelines for project activities.