bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic Versus Open Reversal of a Hartmann Procedure: A Single‐Center Study
Authors: Zimmermann Markus , Hoffmann Martin , Laubert Tilman , Meyer Karl‐Frederik , Jungbluth Thomas , Roblick Uwe‐Johannes , Bruch Hans‐Peter , Schlöricke Erik 
Published: March 2014

AbstractPurpose
Re‐anastomosis after a Hartmann procedure is associated with a higher morbidity and mortality than other elective colorectal operations. The goal of this comparative study was to evaluate whether laparoscopic reversal is a justified operative approach, although the initial operation is most often an emergency laparotomy.MethodsA retrospective analysis was conducted on data collected on all 70 patients who underwent laparoscopic and open reversal of a Hartmann procedure at the Department of Surgery, University of Schleswig–Holstein, Campus Lübeck, between January 1999 and December 2011. Together with general demographic data, the analysis included the indication for the initial Hartmann procedure, time to reversal, intraoperative findings, the choice of operative method, operating time, postoperative pain control, return of normal bowel function, length of hospital stay, and peri‐ and postoperative morbidity and mortality.ResultsIn most patients, the Hartmann procedure was performed after a perforated sigmoid diverticulitis. We were not able to find any statistically significant differences with respect to gender, body mass index (BMI) and American Society of Anesthesiologists classification between the laparoscopic group (LG) (N = 24 patients) and the open group (OG) (N = 46). In the LG, patients were significantly younger (p = 0.019). The median operating time was 210 min (75–245) in the LG, which was significantly longer than in the OG (166 min; 66–230). The statistical analysis of the duration of postoperative analgesic therapy (LG 7 days [6–10]; OG 12 days [6–30] ), return to normal diet (LG 3 days [2–6]; OG 4 days [2–10] ), return of normal bowel function (LG 3 days [2–4]; OG 4 days [2–9] ) and length of hospital stay (LOS) (LG 10 days [8–13]; OG 15 days [8–163]) detected significant differences in advantage for the LG. Unplanned return to theatre during index admission was only necessary in the OG (N = 7, 15.2 %). With a median follow‐up of 8 months (range 1–20), we observed a comparable number of minor complications in both groups but a significantly higher number of major complications in the OG (N = 27, 58.7 %) (p = 0.001). Conversion occurred in three cases (12.5 %). There was no mortality in either of the two groups.ConclusionsThis study was able to demonstrate the feasibility of the laparoscopic approach. In terms of postoperative results it should be seen as equivalent to the open procedure. However, the laparoscopic approach requires profound surgical expertise. The indication should be made after a careful risk/benefit analysis for each individual patient.
Does complete renal denervation translate into superior clinical outcomes? Lessons learned from denervation of accessory renal arteries
Authors: Mendelsohn Farrell O. 
Published: March 2014

Abstract
Pre-clinical studies of renal denervation would suggest that the extent of renal nerve injury correlates with outcomes. The “completeness” of renal nerve injury following renal denervation correlates with treatment-based variables such as the depth of ablation, the number of ablations along the length of the artery, and the number of renal arteries successfully ablated. Renal denervation techniques targeting only main renal arteries may lead to suboptimal results in patients with accessory renal artery anatomy. Technological differences among the different systems may make some more suited for this common anatomical variant. The early clinical experience with renal denervation of accessory renal arteries highlights the importance of complete renal denervation for clinical success.
Relationship between soil P fractions and microbial biomass in an oligotrophic grassland‐desert scrub system
Authors: Perroni Yareni , García‐Oliva Felipe , Tapia‐Torres Yunuen , Souza Valeria 
Published: March 2014

AbstractPhosphorus (P) is an essential element of the biosphere, both as a constituent of living organisms and as a regulator of biological processes. The Cuatro Ciénegas Basin in the central Chihuahuan Desert of Mexico is characterized by extreme P oligotrophy. The aim of this study was to quantify P distribution in soil P fractions, P sorption capacity, and P in microbial biomass in a desert scrub and grassland soil system in the Churince area of the Cuatro Ciénegas Basin over summer and winter seasons. Our objective, as part of an exploration of ecosystem functioning, was to ascertain the relationship between soil P fractions and P in microbial biomass. Our results demonstrate a scarcity of P, mainly in grassland, and also a higher P sorption capacity in grassland soil than in desert scrub. Desert scrub soil retained more P (228 ± 5 μg g−1dry soil) than grassland soil (87 ± 10 μg g−1dry soil), mainly in inorganic forms, but grassland soil retained more P in accessible organic forms. We suggest that biotic controls regulated by access to water shape the dynamics of soil P availability in the Churince grassland‐desert scrub system.
Potential Development of Value‐Added Fishery Products in Underutilized and Commercial Fish Species: Comparative Study of Lipid Quality Indicators
Authors: Agh Naser , Jasour Mohammad Sedigh , Noori Farzaneh 
Published: March 2014

AbstractIn this study, proximate and fatty acid composition in the edible flesh of eight underutilized and five commercial freshwater fish species were compared in order to evaluate the potential of these fish for development of functional value‐added fishery products. The lipid content (% dry weight basis) of investigated fish species ranged from 3.44 to 9.25 in underutilized and 3.73–7.68 in commercial species. In comparison with underutilized fish species, commercial species had higher levels of protein (P < 0.05). The high proportion of EPA+DHA was found with Goldfish (524 mg/100 g flesh), Wels (422 mg/100 g flesh), and Crucian carp (354 mg/100 g flesh), all of which belonged to underutilized group. All studied fish (save Lenkoran) showed values higher than the minimum recommended DHA/EPA value (0.45). The ratios of n‐6/n‐3 found in this study were much lower (save Goatfish) than those cited as a harmful value (4.0 as the maximum value). The PUFA/SFA value of the present fish samples was higher at 1.57 for Goatfish, 1.02 for Lenkoran, 0.68 for Wels, all of these fish belonging to the underutilized group. The highest atherogenic and thrombogenicity index values were generally obtained for commercial species. It seems in respect of comparability of these lipid quality indicators, the underutilized fish species could be highly recommended as an important source of polyunsaturated fatty acids and Max‐EPA products for humans consumption.
Xylo-oligosaccharides alone or in synbiotic combination withBifidobacterium animalissubsp.lactisinduce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study
Authors: Childs Caroline E. , Röytiö Henna , Alhoniemi Esa , Fekete Agnes A. , Forssten Sofia D. , Hudjec Natasa , Lim Ying Ni , Steger Cara J. , Yaqoob Parveen , Tuohy Kieran M. , Rastall Robert A. , Ouwehand Arthur C. , Gibson Glenn R. 
Published: March 2014

Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic (Bifidobacterium animalissubsp.lactisBi-07, 109colony-forming units (CFU)/d) or synbiotic (8 g XOS+109CFU Bi-07/d) was given to healthy adults (25–65 years) for 21 d. The aim was to identify the effect of the supplements on bowel habits, self-reported mood, composition of the gut microbiota, blood lipid concentrations and immune function. XOS supplementation increased mean bowel movements per d (P= 0·009), but did not alter the symptoms of bloating, abdominal pain or flatulence or the incidence of any reported adverse events compared with maltodextrin supplementation. XOS supplementation significantly increased participant-reported vitality (P= 0·003) and happiness (P= 0·034). Lowest reported use of analgesics was observed during the XOS+Bi-07 supplementation period (P= 0·004). XOS supplementation significantly increased faecal bifidobacterial counts (P= 0·008) and fasting plasma HDL concentrations (P= 0·005). Bi-07 supplementation significantly increased faecalB. lactiscontent (P= 0·007), lowered lipopolysaccharide-stimulated IL-4 secretion in whole-blood cultures (P= 0·035) and salivary IgA content (P= 0·040) and increased IL-6 secretion (P= 0·009). XOS supplementation resulted in lower expression of CD16/56 on natural killer T cells (P= 0·027) and lower IL-10 secretion (P= 0·049), while XOS and Bi-07 supplementation reduced the expression of CD19 on B cells (XOS × Bi-07,P= 0·009). The present study demonstrates that XOS induce bifidogenesis, improve aspects of the plasma lipid profile and modulate the markers of immune function in healthy adults. The provision of XOS+Bi-07 as a synbiotic may confer further benefits due to the discrete effects of Bi-07 on the gut microbiota and markers of immune function.
Selenium status affects selenoprotein expression, reproduction, and F1 generation locomotor activity in zebrafish (Danio rerio)
Authors: Penglase Sam , Hamre Kristin , Rasinger Josef D. , Ellingsen Staale 
Published: March 2014

Se is an essential trace element, and is incorporated into selenoproteins which play important roles in human health. Mammalian selenoprotein-coding genes are often present as paralogues in teleost fish, and it is unclear whether the expression patterns or functions of these fish paralogues reflect their mammalian orthologues. Using the model species zebrafish (Danio rerio; ZF), we aimed to assess how dietary Se affects key parameters in Se metabolism and utilisation including glutathione peroxidase (GPX) activity, the mRNA expression of key Se-dependent proteins (gpx1a, gpx1b, sepp1a and sepp1b), oxidative status, reproductive success and F1 generation locomotor activity. From 27 d until 254 d post-fertilisation, ZF were fed diets with graded levels of Se ranging from deficient ( < 0·10 mg/kg) to toxic (30 mg/kg). The mRNA expression of gpx1a and gpx1b and GPX activity responded in a similar manner to changes in Se status. GPX activity and mRNA levels were lowest when dietary Se levels (0·3 mg/kg) resulted in the maximum growth of ZF, and a proposed bimodal mechanism in response to Se status below and above this dietary Se level was identified. The expression of the sepp1 paralogues differed, with only sepp1a responding to Se status. High dietary Se supplementation (30 mg/kg) decreased reproductive success, while the offspring of ZF fed above 0·3 mg Se/kg diet had lower locomotor activity than the other groups. Overall, the novel finding of low selenoprotein expression and activity coinciding with maximum body growth suggests that even small Se-induced variations in redox status may influence cellular growth rates.
The impact of Scottish Government protocols on practice in Scotland
Authors: Steele P R C , Barnes M L , Ross P D 
Published: March 2014

AbstractObjectives:To investigate rates of septorhinoplasty and rhinoplasty in Scotland between 2006 and 2010, and to establish the impact of government legislation.Methods:Data on the rates of rhinoplasty and septorhinoplasty were collected and analysed according to specialty, region and year.Results:In 2006, 754 septorhinoplasty and rhinoplasty cases were recorded (147 per million population), rising to 893 (171 per million population) in 2010. Mean annual rates per million population were 152 (87 per cent of procedures) in ENT, 13.9 (8 per cent) in plastic surgery and 8.7 (8 per cent) in oromaxillofacial surgery. After 2009, there was a 43 per cent reduction in the rhinoplasty rate (p < 0.0001), although the oromaxillofacial surgery rate increased by 68 per cent (p < 0.05). Over the same period, the septorhinoplasty rate increased in ENT (46 per cent, p < 0.0001), and declined in plastic surgery (24 per cent, p = 0.49) and oromaxillofacial surgery (45 per cent, p = 0.05). Overall, the rate for rhinoplasty plus septorhinoplasty only declined by 1 per cent. There was significant regional variation.Conclusion:Overall, septorhinoplasty rates have increased and rhinoplasty rates have decreased. There was only a 1 per cent decrease in the overall rate following the 2009 legislation. Practice differs between regions.
Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study
Authors: Harrow M. , Jobe T. H. , Faull R. N. 
Published: March 2014

BackgroundThis research assesses whether multi-year treatment with antipsychotic medications reduces or eliminates psychosis in schizophrenia. It provides 20 years of longitudinal data on the frequency and severity of psychotic activity in samples of schizophrenia patients (SZ) treatedversusthose not treated with antipsychotic medications.MethodA total of 139 early young schizophrenia and mood-disordered patients were assessed at index hospitalization and then reassessed six times over 20 years for psychosis and other major variables.ResultsAt each follow-up assessment over the 20 years, a surprisingly high percentage of SZ treated with antipsychotics longitudinally had psychotic activity. More than 70% of SZ continuously prescribed antipsychotics experienced psychotic activity at four or more of six follow-up assessments over 20 years. Longitudinally, SZ not prescribed antipsychotics showed significantly less psychotic activity than those prescribed antipsychotics (p < 0.05).ConclusionsThe 20-year data indicate that, longitudinally, after the first few years, antipsychotic medications do not eliminate or reduce the frequency of psychosis in schizophrenia, or reduce the severity of post-acute psychosis, although it is difficult to reach unambiguous conclusions about the efficacy of treatment in purely naturalistic or observational research. Longitudinally, on the basis of their psychotic activity and the disruption of functioning, the condition of the majority of SZ prescribed antipsychotics for multiple years would raise questions as to how many of them are truly in remission.
The effects of circularly polarized laser pulse on generated electron nano-bunches in oscillating mirror model
Authors: Shirozhan M. , Moshkelgosha M. , Sadighi-Bonabi R. 
Published: March 2014

AbstractThe effects of the polarized incident laser pulse on the electrons of the plasma surface and on the reflected pulse in the relativistic laser-plasma interaction is investigated. Based on the relativistic oscillating mirror and totally reflecting oscillating mirror (TROM) regimes, the interaction of the intense polarized laser pulses with over-dense plasma is considered. Based on the effect of ponderomotive force on the characteristic of generated electron nano-bunches, considerable increasing in the localization and charges of nano-bunches are realized. It is found that the circularly polarized laser pulse have Ne/Ncr of 1500 which is almost two and seven times more than the amounts for P-polarized and S-polarized, respectively.
Impacts of recreational fishing in Australia: historical declines, self-regulation and evidence of an early warning system
Authors: YOUNG MATTHEW A. L. , FOALE SIMON , BELLWOOD DAVID R. 
Published: March 2014

SUMMARYOverfishing is a mounting threat to marine ecosystems and food security worldwide. Recreational fisheries are poorly understood and pose governance challenges due to the scarcity of monitoring data. The impact of recreational spearfishing on eastern blue groper (Achoerodus viridis) and grey nurse shark (Carcharias taurus) in Australia was analysed by assessing a chronology of spearfishing publications for historical, ecological and social data. Reported captures of blue groper declined by 90% from 1952–1967. Grey nurse shark captures also declined. Interestingly, early warnings of declines for both species emerged from the spearfishing community 17 and 19 years, respectively, before protection. While recreational fishers may have serious impacts on vulnerable fish species, they could also play a vital role in conservation and advocacy. This highlights the importance of reciprocal communication between fishers, scientists and governments for managing and detecting declines in vulnerable species.
Molecular characterization of an Australian serotype 1Streptococcus pneumoniaeoutbreak
Authors: STAPLES M. , GRAHAM R. M. A. , JENNISON A. V. , ARIOTTI L. , HICKS V. , COOK H. , KRAUSE V. , GIELE C. , SMITH H. V. 
Published: March 2014

SUMMARYSerotype 1Streptococcus pneumoniaeis a cause of invasive pneumococcal disease (IPD) worldwide and has been associated with IPD outbreaks, while carriage is rarely detected in healthy adults or children. This study details an Australian multi-state and territory outbreak of serotype 1S. pneumoniaeIPD between 2010 and 2012. Molecular characterization demonstrated the outbreak was largely due to the clonal expansion of sequence type 306, MLVA type 261S. pneumoniaeserotype 1.
Chondrosarcoma presenting with pulmonary embolism in a 9-year-old girl: a case report
Authors: Pinder Marco A. , Dibardino Daniel J. , Collier Anderson B. , Knudson Jarrod D. 
Published: March 2014

AbstractChondrosarcoma is a malignant bone tumour common in adults, third to myeloma and osteosarcoma, but is exceptionally rare in children. Here we discuss a 9-year-old girl presenting with occlusive right pulmonary artery neoplastic embolus, resulting from a primary right proximal humerus chondrosarcoma. To the best of our knowledge, this the first pediatric and only second overall case reported in the United States of a neoplastic pulmonary embolus resulting from a primary chondrosarcoma.
Objectively measured physical activity levels of young children with congenital heart disease
Authors: Stone Nicola , Obeid Joyce , Dillenburg Rejane , Milenkovic Jovana , MacDonald Maureen J. , Timmons Brian W. 
Published: March 2014

AbstractPhysical activity tends to be lower in school-age children with congenital heart disease than in healthy controls. To the best of our knowledge, objectively measured physical activity levels of preschool-age children with congenital heart disease have not been studied. Methods: A total of 10 children with either coarctation of the aorta (n=6; age 3.8±0.9) or tetralogy of Fallot (n=4, age 4.3±0.9) were recruited from the cardiology unit of McMaster Children’s Hospital. Height (103.7±8.2 cm) and weight (17.3±2.7 kg) measurements were recorded, and physical activity was determined using accelerometry over 7 consecutive days. Patients were compared with age-, sex-, and season of data acquisition-matched controls. Parents completed a questionnaire regarding the child’s physical activity and sedentary behaviours. Results: Patients spent on average 219.4±39.9 minutes engaged in total physical activity per day at the following intensities: light, 147.5±22.3; moderate, 44.0±11.8; moderate-to-vigorous, 71.9±22.6; and vigorous, 27.9±11.7. No significant differences were observed between patients and controls for total physical activity (p=0.80) or any of the intensities (p=0.71, 0.46, 0.43, and 0.45, respectively). Only 40% of patients and controls met the new Canadian Physical Activity Guidelines for the Early Years of at least 180 minutes of physical activity at any intensity every day. Of the patients’ parents, 90% believed that their child was as active, if not more active, than his/her siblings, and 80% of parents reported their child spending 1–3 hours in screen time activities daily. Conclusion: Children aged 3–5 years old with congenital heart disease have comparable physical activity levels to age-, sex-, and season-matched controls, and many do not meet Canadian Physical Activity Guidelines.
Prevalence of overweight and obesity among patients with congenital and acquired heart disease in Kocaeli, Turkey
Authors: Babaoğlu Kadir , Deveci Murat , Kayabey Özlem , Altun Gürkan , Binnetoğlu Köksal 
Published: March 2014

AbstractBackground:Childhood obesity has increased in the last half of the century. The aim of this study was to evaluate the frequency of obesity in the children with congenital or acquired heart disease.Methods:A total of 1410 children were assessed in this study. The study population was composed of 518 children (289 boys, 229 girls) as control group and 892 children (477 boys, 415 girls) as heart disease group. Patients were grouped into four categories: (I) “Clinic control subjects”; (II) “mild heart disease” that has not been treated with either surgical or catheter intervention; (III) congenital heart disease treated with surgical and/or catheter intervention; and (IV) “arrhythmias”. A body mass index ⩾85th percentile was defined as overweight, ⩾95th percentile as obese, and <5th percentile was defined as underweight.Results:We did not detect any association between heart disease and obesity. There was no difference in the rates of overweight, obesity, and underweight between the healthy control subjects and patients with heart disease (8.1%, 13.3%, and 5.0%; 9.0%, 10.7%, and 4.7%, respectively, p=0.145). All subgroups had a similar prevalence of underweight, overweight, and obesity as the healthy control population. Within the heart disease population, the overall prevalence rates for overweight, obesity, and underweight were similar between the boys and girls.Conclusion:Obesity is a common problem in children with heart disease, at least in general population. It is an important additional risk factor for long-term cardiovascular morbidity and mortality in children with heart disease. Precautions to prevent obesity should be a part of paediatric cardiologist’s examination.
High-risk single ventricle palliation in children with Down syndrome: single institution experience
Authors: Ooi Yinn K. , Sinha Pranava , Gierdalski Marcin , Harahsheh Ashraf 
Published: March 2014

AbstractBackground: Of the children with Down syndrome 40–50% have cardiac defects and the majority of these cardiac defects are amenable to biventricular repair. The outcome of single ventricle palliation is improving; nonetheless, there are limited data on Down syndrome patients with associated high-risk factors undergoing single ventricle palliation. Our aim was to study the outcomes of children with Down syndrome and high-risk factors on the single ventricle palliation pathway. Methods: A retrospective study on all patients with Down syndrome on the single ventricle palliation pathway from 2005 until 2011 was conducted. Operative, clinical, echocardiographic, haemodynamic data, and follow-up data were reviewed. Results: A total of 310 patients underwent at least one single ventricle surgical intervention. Of those, eight patients had Down syndrome, five of which had associated risk factors – low birth weight, high pulmonary vascular resistance, pulmonary vein stenosis, significant atrioventricular valve regurgitation, and extracardiac anomalies. Mortality in the high-risk group was 80% (4/5), compared with 33% (1/3) in the non-high-risk patients. Overall, after a median follow-up period of 138 days (8–576 days), only 37.5% (3/8) of patients were alive. Conclusion: Despite many improvements in the care of single ventricle patients, the fate of those with Down syndrome and associated high-risk factors remains poor. Further multicentre longer-term studies are needed to validate and quantify the cumulative effects of negative prognostic factors in this complex group of patients.