bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Reconstruction of a High-Energy Diffraction Microscopy Sample Using Multi-modal Serial Sectioning with High-Precision EBSD and Surface Profilometry
Authors: Sparks Gregory , Mason Simon A. , Chapman Michael G. , Park Jun-Sang , Sharma Hemant , Kenesei Peter , Niezgoda Stephen R. , Mills Michael J. , Uchic Michael D. , Shade Paul A. , Obstalecki Mark 
Published: July 2024

AbstractHigh-energy diffraction microscopy (HEDM) combined with in situ mechanical testing is a powerful nondestructive technique for tracking the evolving microstructure within polycrystalline materials during deformation. This technique relies on a sophisticated analysis of X-ray diffraction patterns to produce a three-dimensional reconstruction of grains and other microstructural features within the interrogated volume. However, it is known that HEDM can fail to identify certain microstructural features, particularly smaller grains or twinned regions. Characterization of the identical sample volume using high-resolution surface-specific techniques, particularly electron backscatter diffraction (EBSD), can not only provide additional microstructure information about the interrogated volume but also highlight opportunities for improvement of the HEDM reconstruction algorithms. In this study, a sample fabricated from undeformed “low solvus, high refractory” nickel-based superalloy was scanned using HEDM. The volume interrogated by HEDM was then carefully characterized using a combination of surface-specific techniques, including epi-illumination optical microscopy, zero-tilt secondary and backscattered electron imaging, scanning white light interferometry, and high-precision EBSD. Custom data fusion protocols were developed to integrate and align the microstructure maps captured by these surface-specific techniques and HEDM. The raw and processed data from HEDM and serial sectioning have been made available via the Materials Data Facility (MDF) at https://doi.org/10.18126/4y0p-v604 for further investigation.
Enhanced electrochemical validation of metal organic frameworks-derived TiO2/Fe-TiO2 as an active electrode for supercapacitors
Authors: Cherupurakal Nizamudeen , Krishnapriya R. , Bojarajan Arjunkumar , Ramachandran Tholkappiyan , Sangaraju Sambasivam , Mozumder Mohammad Sayem , Mourad Abdel-Hamid I. 
Published: July 2024

AbstractDeveloping supercapacitor materials that are both efficient and durable, with high cycle life and specific energy, poses a significant challenge due to issues in electrodes such as volume expansion and electrode degradation that occur over time. This work reports a simple, novel, and cost-effective synthesis method to fabricate high surface area “Iron (Fe) doped TiO2 materials” via the metal-organic framework (MOF) route for supercapacitor application. Morphological analysis revealed a disc-like shaped pattern for pristine TiO2 (PT), and a cuboid form for Fe-doped TiO2 (FeT). The electrochemical investigation of MOF-derived PT and FeT electrode materials demonstrated the superior performance of FeT. Cyclic Voltammetry revealed enhanced electrochemical properties in FeT. Galvanostatic charge-discharge measurements confirmed FeT’s higher energy storage capacity, reaching a maximum specific capacitance of 925 Fg− 1. Long-term cycling tests exhibited excellent stability, with FeT retaining 67% of its initial capacitance after 6000 cycles and showing prolonged self-discharge. Overall, the results underscore the potential of Fe-doped TiO2 for high-performance supercapacitors.
More Climate Finance from More Countries?
Authors: Pauw W. Pieter , König-Sykorova Michael , Valverde María José , Zamarioli Luis H. 
Published: July 2024

AbstractPurpose of ReviewThis paper analyses the options to broaden the base of climate finance provided by countries in a mixed-methods review. It (1) reviews Non-Annex II countries’ commitments in international agreements, declarations, and agendas; (2) provides and applies a literature-based review of criteria to identify countries’ responsibilities and capabilities to provide finance; (3) reviews institutional affiliation; and (4) reviews countries’ willingness to provide finance through their contributions to 27 relevant multilateral funds.Recent FindingsScaling up climate finance has been a political and operational priority for the UN climate negotiations. However, the Annex II list of countries that commit to support developing countries financially with mitigation and adaptation has hardly changed since 1992. Given countries’ diverse emission pathways and economic development as well as geopolitical dynamics, Annex II is turning into a weakness of the UNFCCC in times when developing countries’ climate finance needs are increasing.SummaryOur largely qualitative analysis indicates that Eastern European countries, Russia, South Korea, Türkiye, Monaco, and Gulf States (including Saudi Arabia) meet many justifications for further negotiations about the expansion of the climate finance provider base. However, we argue against a continued rigid dichotomy of providers and recipients. We recommend four innovations going forward, including establishing ‘net recipients’ as a third category; this 1) broadens the base; 2) increases climate finance; and 3) could increase effectiveness and cooperation. More research is needed on the role of countries’ vulnerability and debt levels in discussions on climate finance provision.
Exploring microbial diversity and functional gene dynamics associated with the microbiome of Sof Umer cave, Ethiopia
Authors: Meka Abu Feyisa , Bekele Gessesse Kebede , Abas Musin Kelel , Gemeda Mesfin Tafesse 
Published: July 2024

AbstractSof Umer Cave is the largest cave in East Africa and located in southeastern Ethiopia, is an unexplored extreme environment harboring novel microbes and potential genetic resources. However, the microbial ecology and their potential genetic resource, remain undiscovered. The purpose of this study was to employ high-throughput shotgun sequencing to explore the microbial diversity and functional gene dynamics within the microbiomes of Sof Umer Cave. High-molecular-weight DNA was extracted from homogenized sample using the GeneAll DNA Soil Mini Kit and 1% CTAB-SDS method. Purified environmental DNA was sequenced using a NovaSeq PE150. Microbial gene analysis revealed that Sof Umer Cave is primarily inhabited by Protobacteria, Actinobacteria, Bacteroidota, Verrucomicrobiota, Acidobacteiota, and Cyanobacteria, according to the Micro-RN database. The functional genes identified through the KEGG, eggNOG, and CAZy databases included 44,780 genes involved in metabolism and the biosynthesis of bioactive compounds. However, 34,716 genes related to metabolic processes remained unidentified, suggesting the presence of potentially novel genes for the discovery of natural bioactive compounds. Additionally, functional gene modeling using the FBA-built metabolic model, Model seed and MS2-prokaryotic metabolic model revealed 1,742 reactions, 1,542 compounds, and the addition of 302 new reactions during gap filling. Finally, the results revealed that the Sof Umer Cave is a reservoir for novel microbes and diverse functional genes, offering potential for the discovery of natural bioactive compounds.
Inside-out, antimicrobial resistance mediated by efflux pumps in clinical strains of Acinetobacter baumannii isolated from burn wound infections
Authors: Hernández-Durán Melissa , Colín-Castro Claudia Adriana , Fernández-Rodríguez Diana , Delgado Gabriela , Morales-Espinosa Rosario , Martínez-Zavaleta María Guadalupe , Shekhar Chandra , Ortíz-Álvarez Jossue , García-Contreras Rodolfo , Franco-Cendejas Rafael , López-Jácome Luis Esaú 
Published: July 2024

Abstract
Acinetobacter baumannii belongs to the ESKAPE group. It is classified as a critical priority group by the World Health Organization and a global concern on account of its capacity to acquire and develop resistance mechanisms to multiple antibiotics. Data from the United States indicates 500 deaths annually. Resistance mechanisms of this bacterium include enzymatic pathways such as ß-lactamases, carbapenemases, and aminoglycoside-modifying enzymes, decreased permeability, and overexpression of efflux pumps. A. baumannii has been demonstrated to possess efflux pumps, which are classified as members of the MATE family, RND and MFS superfamilies, and SMR transporters. The aim of our work was to assess the distribution of efflux pumps and their regulatory gene expression in clinical strains of A. baumannii isolated from burned patients.

Methods
From the Clinical Microbiology Laboratory at the Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra collection in Mexico, 199 strains were selected. Antibiotics susceptibilities were performed by broth microdilutions to determine minimal inhibitory concentrations. Phenotypic assays with efflux pump inhibitors were conducted using carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and phenylalanine-arginine ß-naphthylamide (PAßN) in conjunction with amikacin, ceftazidime, imipenem, meropenem and levofloxacin. A search was conducted for structural genes that are linked to efflux pumps, and the relative expression of the adeR, adeS, and adeL genes was analyzed.

Results
Among a total of 199 strains, 186 exhibited multidrug resistance (MDR). Fluoroquinolones demonstrated the highest resistance rates, while minocycline and amikacin displayed comparatively reduced resistance rates (1.5 and 28.1, respectively). The efflux activity of fluorquinolones exhibited the highest phenotypic detection (from 85 to 100%), while IMP demonstrated the lowest activity of 27% with PAßN and 43.3% with CCCP. Overexpression was observed in adeS and adeL, with adeR exhibiting overexpression.
Concluding that clinical strains of A. baumannii from our institution exhibited efflux pumps as one of the resistance mechanisms.
Diversity and spatial genetic structure of the common opossum (Didelphis marsupialis) in an urban matrix of Northwestern Colombia
Authors: Henao-Sáenz Carolina , Herrera-Pérez Juliana , Soto-Calderón Iván D. 
Published: July 2024

AbstractThe common opossum (Didelphis marsupialis) is a marsupial widely distributed in the Neotropics, where it lives in urbanized environments. The apparent scarcity and fragmentation of available habitat, and high rates of vehicle collisions, may represent barriers to dispersal. To assess the functional connectivity of this species and its potential use as a model in urban ecology, we evaluated the structure and genetic diversity of opossums in the metropolitan area of the Aburrá Valley (AMVA), Colombia, using sequences of the mitochondrial Cytochrome B (Cytb) gene and nine autosomal microsatellite loci. Although Cytb presented low levels of variation, microsatellite markers revealed high genetic diversity (He = 0.852 and Ho = 0.698). The geographic distribution of mitochondrial lineages and a spatial principal component analysis (sPCA) of microsatellites showed the absence of genetic structure and effective barriers to dispersal of opossums in the study area. This scenario suggests that hostile landscapes such as those in urban environments may be suitable enough to allow the effective connectivity of some species such as the common opossum and others with high dispersal ability in urbanized areas. Nonetheless, it is necessary to evaluate the impact of releases of rescued fauna made by the environmental authority on the population structure of urban opossums.
The Varied Role of Atmospheric Rivers in Arctic Snow Depth Variations
Authors: Li Haili , Ke Chang‐Qing , Shen Xiaoyi , Zhu Qinghui , Cai Yu , Luo Lanhua 
Published: July 2024

AbstractThe state and fate of snow on sea ice are crucial in the mass and energy balance of sea ice. The function of atmospheric rivers (ARs) on snow depth over sea ice has not been measured thus far, limiting the understanding of the mechanism of snow depth changes. Here, the effect of ARs on snow depth changes was explored. We found that increased AR frequency is responsible for winter‐autumn snow accumulation and spring‐summer snow melting. The 2 m air temperature (T2m), rainfall, snowfall, mean net longwave radiation (NLR), mean net shortwave radiation (NSR) and cloud radiative effect (CRE) during ARs explain the changes in snow depth triggered by AR occurrence. This work helps us understand how ARs affect snow depth changes through related physical processes, promotes an understanding of climate systems and provides a theoretical basis for snow treatment in sea ice models.
Reinterpreting ENSO's Role in Modulating Impactful Precipitation Events in California
Authors: Guirguis Kristen , Hatchett Benjamin , Gershunov Alexander , DeFlorio Michael , Clemesha Rachel , Brandt W. Tyler , Haleakala Kayden , Castellano Christopher , Luna Niño Rosa , Tardy Alexander , Anderson Michael , Ralph F. Martin 
Published: July 2024

AbstractWater years (WY) 2017 and 2023 were anomalously wet for California, each alleviating multiyear drought. In both cases, this was unexpected given La Niña conditions, with most seasonal forecasts favoring drier‐than‐normal winters. We analyze over seven decades of precipitation and snow records along with mid‐tropospheric circulation to identify recurring weather patterns driving California precipitation and Sierra Nevada snowpack. Tropical forcing by ENSO causes subtle but important differences in these wet weather patterns, which largely drives the canonical seasonal ENSO‐precipitation relationship. However, the seasonal frequency of these weather patterns is not strongly modulated by ENSO and remains a primary source of uncertainty for seasonal forecasting. Seasonal frequency of ENSO‐independent weather patterns was a major cause of anomalous precipitation in WY2017, record‐setting snow in WY2023, and differences in precipitation outcome during recent El Niño winters 1983, 1998, and 2016. Improved understanding of recurrent atmospheric weather patterns could help to improve seasonal precipitation forecasts.
Broadband nonreciprocal thermal emissivity and absorptivity
Authors: Shayegan Komron J. , Hwang Jae S. , Zhao Bo , Raman Aaswath P. , Atwater Harry A. 
Published: July 2024

AbstractA body that violates Kirchhoff’s law of thermal radiation exhibits an inequality in its spectral directional absorptivity and emissivity. Achieving such an inequality is of fundamental interest as well as a prerequisite for achieving thermodynamic limits in photonic energy conversion1 and radiative cooling2. Thus far, inequalities in the spectral directional emissivity and absorptivity have been limited to narrow spectral resonances3, or wavelengths well beyond the infrared regime4. Bridging the gap from basic demonstrations to practical applications requires control over a broad spectral range of the unequal spectral directional absorptivity and emissivity. In this work, we demonstrate broadband nonreciprocal thermal emissivity and absorptivity by measuring the thermal emissivity and absorptivity of gradient epsilon-near-zero InAs layers of subwavelength thicknesses (50 nm and 150 nm) with an external magnetic field. The effect occurs in a spectral range (12.5–16 μm) that overlaps with the infrared transparency window and is observed at moderate (1 T) magnetic fields.
CELF4 (rs1786814) gene polymorphism and speckle-tracking Echocardiography for cardiovascular complications in childhood cancer survivors
Authors: Ragab Seham M. , El-Hawy Mahmoud A. , El-Hefnawy Sally M. , El –Deeb Hend M. A. , Elfalah Amany S. , Mahmoud Asmaa A. 
Published: July 2024

Abstract
Background
Despite a well-known dose-dependent association between the risk of cardiac dysfunction and anthracycline, the risk of cardiac dysfunction for any given anthracycline dose varies between patients. So, we assessed CELF4 (rs1786814) gene polymorphism on anthracycline-related cardiotoxicity in childhood cancer survivors (CCS).

Methods
This comparative cross-sectional study included 53 CCS who had regular follow-up visits at the Pediatric Oncology Unit, Menoufia University Hospital. CELF4 (rs1786814) gene polymorphism and conventional and speckle-tracking Echocardiography were done for all survivors.

Results
Regarding CELF4 (rs1786814) genotypes, significant differences existed between the studied groups with a predominance of GG homozygous mutation. For Echocardiographic findings, the ejection fraction and end-systolic diameter compared to the control group, were significantly lower in the survivors group. Speckle- tracking Echocardiography showed a significant difference regarding (GLPS-A4C) and (GLPS-LAX), with no significant difference regarding (GLPS-A2C), (GLPS-Avg) and left atrium between the studied groups. Multivariate logistic regression analysis illustrated a statistically significant relation between cumulative anthracycline dose >300 mg/m2 and CLEF4 (rs1786814) genotypes (GG and GA) and the risk of cardiotoxicity with more significance in GG mutation.

Conclusion
Early detection of ventricular dysfunction in CCS with subclinical cardiotoxicity with regular follow-up is promising before the development of life-threatening complications.

Impact

Early detection of anthracycline-related cardiotoxicity in childhood cancer survivors (CCS) after finishing chemotherapy.

CLEF4 (rs1786814) GG variant is more significant in CCS exposed to high-dose anthracycline.

GLPS holds promise as an early predictor of late left ventricular dysfunction and subclinical cardiotoxicity in CCS.
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial
Authors: Sempach Lukas , Doll Jessica P. K. , Limbach Verena , Marzetta Flavia , Schaub Anna-Chiara , Schneider Else , Kettelhack Cedric , Mählmann Laura , Schweinfurth-Keck Nina , Ibberson Mark , Lang Undine E. , Schmidt André 
Published: July 2024

AbstractWe recently indicated that four-week probiotic supplementation significantly reduced depression along with microbial and neural changes in people with depression. Here we further elucidated the biological modes of action underlying the beneficial clinical effects of probiotics by focusing on immune-inflammatory processes. The analysis included a total of N = 43 participants with depression, from which N = 19 received the probiotic supplement and N = 24 received a placebo over four weeks, in addition to treatment as usual. Blood and saliva were collected at baseline, at post-intervention (week 4) and follow-up (week 8) to assess immune-inflammatory markers (IL-1β, IL-6, CRP, MIF), gut-related hormones (ghrelin, leptin), and a stress marker (cortisol). Furthermore, transcriptomic analyses were conducted to identify differentially expressed genes. Finally, we analyzed the associations between probiotic-induced clinical and immune-inflammatory changes. We observed a significant group x time interaction for the gut hormone ghrelin, indicative of an increase in the probiotics group. Additionally, the increase in ghrelin was correlated with the decrease in depressive symptoms in the probiotics group. Transcriptomic analyses identified 51 up- and 57 down-regulated genes, which were involved in functional pathways related to enhanced immune activity. We identified a probiotic-dependent upregulation of the genes ELANE, DEFA4 and OLFM4 associated to immune activation and ghrelin concentration. These results underscore the potential of probiotic supplementation to produce biological meaningful changes in immune activation in patients with depression. Further large-scale mechanistic trials are warranted to validate and extend our understanding of immune-inflammatory measures as potential biomarkers for stratification and treatment response in depression. Trial Registration: www.clinicaltrials.gov, identifier: NCT02957591.
Surface-binding molecular multipods strengthen the halide perovskite lattice and boost luminescence
Authors: Kim Dong-Hyeok , Woo Seung-Je , Huelmo Claudia Pereyra , Park Min-Ho , Schankler Aaron M. , Dai Zhenbang , Heo Jung-Min , Kim Sungjin , Reuveni Guy , Kang Sungsu , Kim Joo Sung , Yun Hyung Joong , Park Jinwoo , Park Jungwon , Yaffe Omer , Rappe Andrew M. , Lee Tae-Woo 
Published: July 2024

AbstractReducing the size of perovskite crystals to confine excitons and passivating surface defects has fueled a significant advance in the luminescence efficiency of perovskite light-emitting diodes (LEDs). However, the persistent gap between the optical limit of electroluminescence efficiency and the photoluminescence efficiency of colloidal perovskite nanocrystals (PeNCs) suggests that defect passivation alone is not sufficient to achieve highly efficient colloidal PeNC-LEDs. Here, we present a materials approach to controlling the dynamic nature of the perovskite surface. Our experimental and theoretical studies reveal that conjugated molecular multipods (CMMs) adsorb onto the perovskite surface by multipodal hydrogen bonding and van der Waals interactions, strengthening the near-surface perovskite lattice and reducing ionic fluctuations which are related to nonradiative recombination. The CMM treatment strengthens the perovskite lattice and suppresses its dynamic disorder, resulting in a near-unity photoluminescence quantum yield of PeNC films and a high external quantum efficiency (26.1%) of PeNC-LED with pure green emission that matches the Rec.2020 color standard for next-generation vivid displays.
Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults
Authors: Pozarickij Alfred , Gan Wei , Lin Kuang , Clarke Robert , Fairhurst-Hunter Zammy , Koido Masaru , Kanai Masahiro , Okada Yukinori , Kamatani Yoichiro , Bennett Derrick , Du Huaidong , Chen Yiping , Yang Ling , Avery Daniel , Guo Yu , Yu Min , Yu Canqing , Schmidt Valle Dan , Lv Jun , Chen Junshi , Peto Richard , Collins Rory , Li Liming , Chen Zhengming , Millwood Iona Y. , Walters Robin G. ,   China Kadoorie Biobank Collaborative Group
Published: July 2024

AbstractElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated that BP traits contribute differently to the causal associations of BP with CVD. In particular, only pulse pressure was independently causally associated with carotid plaque. These findings reinforce the need for studies in diverse populations to understand the genetic determinants of BP traits and their roles in disease risk.