bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and hotspots of energy-based imaging in thoracic disease: a bibliometric analysis
Authors: Chen Yufan , Wu Ting , Zhu Yangtong , Chen Jiawei , Gao Chen , Wu Linyu 
Published: August 2024

Abstract
Objective
To conduct a bibliometric analysis of the prospects and obstacles associated with dual- and multi-energy CT in thoracic disease, emphasizing its current standing, advantages, and areas requiring attention.

Methods
The Web of Science Core Collection was queried for relevant publications in dual- and multi-energy CT and thoracic applications without a limit on publication date or language. The Bibliometrix packages, VOSviewer, and CiteSpace were used for data analysis. Bibliometric techniques utilized were co-authorship analyses, trend topics, thematic map analyses, thematic evolution analyses, source’s production over time, corresponding author’s countries, and a treemap of authors’ keywords.

Results
A total of 1992 publications and 7200 authors from 313 different sources were examined in this study. The first available document was published in November 1982, and the most cited article was cited 1200 times. Siemens AG in Germany emerged as the most prominent author affiliation, with a total of 221 published articles. The most represented scientific journals were the “European Radiology” (181 articles, h-index = 46), followed by the “European Journal of Radiology” (148 articles, h-index = 34). Most of the papers were from Germany, the USA, or China. Both the keyword and topic analyses showed the history of dual- and multi-energy CT and the evolution of its application hotspots in the chest.

Conclusion
Our study illustrates the latest advances in dual- and multi-energy CT and its increasingly prominent applications in the chest, especially in lung parenchymal diseases and coronary artery diseases. Photon-counting CT and artificial intelligence will be the emerging hot technologies that continue to develop in the future.

Critical relevance statement
This study aims to provide valuable insights into energy-based imaging in chest disease, validating the clinical application of multi-energy CT together with photon-counting CT and effectively increasing utilization in clinical practice.

Key Points

Bibliometric analysis is fundamental to understanding the current and future state of dual- and multi-energy CT.

Research trends and leading topics included coronary artery disease, pulmonary embolism, and radiation dose.

All analyses indicate a growing interest in the use of energy-based imaging techniques for thoracic applications.

Graphical Abstract
Effects of superplasticizer on properties of calcined ginger nuts-based grouting material for earthen site cracks
Authors: Wen Xin , Wang Nan , Zhang Jingke , Zhang Lixiang , Wei Yanfei , Gu Wenting 
Published: August 2024

Abstract
Grout injection is an effective technique for repairing cracks in earthen sites. This study aims to address the challenges of Calcined Ginger Nuts (CGN)-based grout and enhance its engineering performance by investigating the compatibility of different superplasticizers. We examined the effects of Polycarboxylate Superplasticizer (PCE) and Naphthalene Superplasticizer (PNS) on the properties of CGN-based grout, focusing on fluidity, rheological properties, mechanical strength, volume stability, color difference, and pore structure. The engineering applicability of the optimized CGN-based grout with superplasticizers was assessed using COMSOL Multiphysics. The results show that fluidity increased with higher dosages of PCE and PNS. The grout containing these superplasticizers behaved as a shear-thinning fluid, following the power law model. Specifically, the consistency coefficient of grout with 0.5 wt% PCE and PNS decreased by 39.73% and 64.83%, respectively. Additionally, 2.9 wt% PCE and PNS reduced volume shrinkage rate by 6.86% and 6.27%, respectively. Initially, increasing the dosage of PCE and PNS improved compressive and flexural strength, but these properties later declined. XRD analysis revealed that PNS above 1.1 wt% and PCE weakened the hydration reaction, while both superplasticizers promoted carbonation. Mercury Intrusion Porosimetry (MIP) showed that 1.1 wt% PCE and PNS reduced the proportion of capillary pores by 13.79% and 10.11%, respectively. Based on these findings, 0.5 wt% PNS demonstrated the best compatibility with CGN-based grout, whereas PCE showed poor compatibility. Numerical simulations using COMSOL Multiphysics confirmed that 0.5 wt% PNS provided superior grouting effectiveness. Therefore, the CGN based grout with 0.5wt% PNS demonstrates excellent engineering performance and applicability. This study offers valuable insights into optimizing CGN-based grout for the preservation of earthen sites.
A new insight on the genus Pteridium (Dennstaedtiaceae) in Europe based on a revision in the flora of Slovakia
Authors: Peregrym Mykyta , Turisová Ingrid , Turis Peter 
Published: August 2024

Abstract
Background
The genus Pteridium Gled. ex Scop. was thought to be monotypic with the cosmopolitan species P. aquilinum (L.) Kuhn. for many years. However, morphological variations among these plants in different regions have been noted since the 1940’s, leading to the description of new taxa later. Molecular investigations, while not resolving all taxonomical questions within the genus, have highlighted its rich genetic diversity globally, confirming the status of several previously described species and subspecies. This wealth of data has prompted revisions of the Pteridium genus in regional floras, with Northern Eurasia serving as a central arena for such studies in the last 30 years. Recent data suggest that the European flora comprises a single species, P. aquilinum, with two subspecies, P. a. subsp. aquilinum and P. a. subsp. pinetorum (C.N. Page & R.R. Mill) J.A. Thomson. However, their distribution within the continent remains unclear. Therefore, this study aims to elucidate the representation and distribution of Pteridium taxa in Slovakia with an attempt to describe natural ranges of P. aquilinum subspecies based on herbarium materials and citizen science data within Europe for a whole.

Results
It is confirmed that the genus Pteridium is represented by the single species with two mentioned subspecies in the flora of Europe, as well as in the flora of Slovakia. The distribution of these subspecies is mapped in the country. Additionally, we discuss the ranges of these subspecies for a whole, and we evidence the growth of P. aquilinum subsp. pinetorum within the Netherlands, Czechia, Austria, Hungary and Romania for the first time. Also, two new combinations of taxa from the Asian part of Russia are offered.

Conclusion
Our study is a significant contribution in the present knowledge about the distribution and taxonomy of P. aquilinum, however it also shows that many questions concerning this taxon and its infraspecific taxa remain open. Additional field investigations and herbarium processing should be carried out for detailed explorations of biological and ecological peculiarities of the mentioned subspecies, and for the clear understanding of their regional distribution. Such explorations also might become a basis for new syntaxonomic revisions.
Mechanism exploration of synergistic photo-immunotherapy strategy based on a novel exosome-like nanosystem for remodeling the immune microenvironment of HCC
Authors: Chen Yichi , Li Xudong , Shang Haitao , Sun Yucao , Wang Chunyue , Wang Xiaodong , Tian Huimin , Yang Huajing , Zhang Lei , Deng Liwen , Yang Kuikun , Wu Bolin , Cheng Wen 
Published: August 2024

AbstractThe immunosuppressive tumor microenvironment (TME) has become a major challenge in cancer immunotherapy, with abundant tumor-associated macrophages (TAMs) playing a key role in promoting tumor immune escape by displaying an immunosuppressive (M2) phenotype. Recently, it was reported that M1 macrophage-derived nanovesicles (M1NVs) can reprogram TAMs to an anti-tumor M1 phenotype, thereby significantly alleviating the immunosuppressive TME and enhancing the anti-tumor efficacy of immunotherapy. Herein, we developed M1NVs loaded with mesoporous dopamine (MPDA) and indocyanine green (ICG), which facilitated the recruitment of M2 TAMs through synergistic photothermal and photodynamic therapy. Thereafter, M1NVs can induce M1 repolarization of TAMs, resulting in increased infiltration of cytotoxic T lymphocytes within the tumor to promote tumor regression. This study investigated the effect of phototherapy on the immune environment of liver cancer using single-cell RNA sequencing (scRNA-seq) by comparing HCC tissues before and after MPDA/ICG@M1NVs + NIR treatment. The results showed significant shifts in cell composition and gene expression, with decreases in epithelial cells, B cells, and macrophages and increases in neutrophils and myeloid cells. Additionally, gene analysis indicated a reduction in pro-inflammatory signals and immunosuppressive functions, along with enhanced B-cell function and anti-tumor immunity, downregulation of the Gtsf1 gene in the epithelial cells of the MPDA/ICG @M1NVs + NIR group, and decreased expression of the lars2 gene in immune subpopulations. Eno3 expression is reduced in M1 macrophages, whereas Clec4a3 expression is downregulated in M2 macrophages. Notably, the B cell population decreased, whereas Pou2f2 expression increased. These genes regulate cell growth, death, metabolism, and tumor environment, indicating their key role in HCC progression. This study highlights the potential for understanding cellular and molecular dynamics to improve immunotherapy.
Graphical Abstract
Assessing inequality of opportunities to child health and nutrition: comparison of Bangladesh and Pakistan
Authors: Zahid GulRukh , Nasir Hamna , sohail Fouzia 
Published: August 2024

AbstractThe bright future of any society is always associated with its upcoming generation. Children are the future prosperity of any nation as they are productive workers of tomorrow. The main objective of this study is to estimate the opportunities available for children under age of 5 years and their mothers for different regions of Pakistan and Bangladesh. The core idea of this study is to access and compare Pakistan with Bangladesh as it was previously a poor and struggling part of it. Data of this study are gathered from Bangladesh Demographic Health Survey and Pakistan Demographic Health Survey for the year 2017–18. The overall comparison of Pakistan and Bangladesh had put Pakistan in a situation where it lagged in every aspect of health-related facilities provided to its citizen. Governments should focus on providing economic opportunities, Health, education, and nutrition to enhance regional and area-level living standards. Further, rural areas should be more focused, especially by the Government of Pakistan.
Accuracy of 3D real-time MRI temperature mapping in gel phantoms during microwave heating
Authors: Dietrich Olaf , Lentini Sergio , Öcal Osman , Bour Pierre , Faller Thibaut L. , Ozenne Valéry , Ricke Jens , Seidensticker Max 
Published: August 2024

Abstract
Background
Interventional magnetic resonance imaging (MRI) can provide a comprehensive setting for microwave ablation of tumors with real-time monitoring of the energy delivery using MRI-based temperature mapping. The purpose of this study was to quantify the accuracy of three-dimensional (3D) real-time MRI temperature mapping during microwave heating in vitro by comparing MRI thermometry data to reference data measured by fiber-optical thermometry.

Methods
Nine phantom experiments were evaluated in agar-based gel phantoms using an in-room MR-conditional microwave system and MRI thermometry. MRI measurements were performed for 700 s (25 slices; temporal resolution 2 s). The temperature was monitored with two fiber-optical temperature sensors approximately 5 mm and 10 mm distant from the microwave antenna. Temperature curves of the sensors were compared to MRI temperature data of single-voxel regions of interest (ROIs) at the sensor tips; the accuracy of MRI thermometry was assessed as the root-mean-squared (RMS)-averaged temperature difference. Eighteen neighboring voxels around the original ROI were also evaluated and the voxel with the smallest temperature difference was additionally selected for further evaluation.

Results
The maximum temperature changes measured by the fiber-optical sensors ranged from 7.3 K to 50.7 K. The median RMS-averaged temperature differences in the originally selected voxels ranged from 1.4 K to 3.4 K. When evaluating the minimum-difference voxel from the neighborhood, the temperature differences ranged from 0.5 K to 0.9 K. The microwave antenna and the MRI-conditional in-room microwave generator did not induce relevant radiofrequency artifacts.

Conclusion
Accurate 3D real-time MRI temperature mapping during microwave heating with very low RMS-averaged temperature errors below 1 K is feasible in gel phantoms.

Relevance statement
Accurate MRI-based volumetric real-time monitoring of temperature distribution and thermal dose is highly relevant in clinical MRI-based interventions and can be expected to improve local tumor control, as well as procedural safety by extending the limits of thermal (e.g., microwave) ablation of tumors in the liver and in other organs.

Key Points

Interventional MRI can provide a comprehensive setting for the microwave ablation of tumors.

MRI can monitor the microwave ablation using real-time MRI-based temperature mapping.

3D real-time MRI temperature mapping during microwave heating is feasible.

Measured temperature errors were below 1 °C in gel phantoms.

The active in-room microwave generator did not induce any relevant radiofrequency artifacts.

Graphical Abstract
Antimicrobial printed linen fabric by using brewer’s yeast enzyme
Authors: Ibrahim Nermin Atef , Zaher Amira Ragheb , El-Hennawi Heba Mohamed 
Published: August 2024

Abstract
Background
In this research, a brewer’s yeast suspension was used to biotreat raw linen fibers under a range of different circumstances utilizing an ultrasonic cleaner device. In order to optimize circumstances for the treatment process, this extensive work is focused on examining the variables that could affect the biotreatment, such as the amount of brewer’s yeast used, the duration, the temperature of the treatment, and the pH throughout the treatment. After enzymatic treatment, the printing process utilizing turmeric natural dye was used. Variable assesses were conducted to determine the steaming time, thermofixation time, pH of the printing paste, types of dyes, and types of fabrics. How these elements affected the wettability and fabric color strength is investigated. To better comprehend, scanning electron microscope (SEM) was used to study the morphology of treated and untreated linen samples. The effects of treating the fibers with yeast enzyme on their multifunctional qualities, such as color and antibacterial activity against gram-positive bacteria like Staphylococcusaureus and gram-negative bacteria like Escherichia coli, were assessed.

Results
Results demonstrated that the enzyme extract, which predominantly contains lipase, amylase, and protease enzymes that develop the fabric printability, is responsible for the increase of color strength which increased by about 152.27% with good fastness properties compared by the untreated printed samples.

Conclusions
The overall findings showed that the treated fabrics have superior color fastness and antibacterial properties when compared to the untreated fabrics, demonstrating that the procedure of production used to create these multifunctional linen fabrics is environmentally friendly.
ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development
Authors: Mah Sophia Y. Y. , Vanyai Hannah K. , Li-Wai-Suen Connie S. N. , Garnham Alexandra L. , Wynn Jessica , Bergamasco Maria I. , Malelang Shezlie , Wilcox Stephen , Biben Christine , Smyth Gordon K. , Thomas Tim , Voss Anne K. 
Published: August 2024

ABSTRACT
Inhibitor of growth 4 and 5 (ING4, ING5) are structurally similar chromatin-binding proteins in the KAT6A, KAT6B and KAT7 histone acetyltransferase protein complexes. Heterozygous mutations in the KAT6A or KAT6B gene cause human disorders with cardiac defects, but the contribution of their chromatin-adaptor proteins to development is unknown. We found that Ing5−/− mice had isolated cardiac ventricular septal defects. Ing4−/−Ing5−/− embryos failed to undergo chorioallantoic fusion and arrested in development at embryonic day 8.5, displaying loss of histone H3 lysine 14 acetylation, reduction in H3 lysine 23 acetylation levels and reduced developmental gene expression. Embryonic day 12.5 Ing4+/−Ing5−/− hearts showed a paucity of epicardial cells and epicardium-derived cells, failure of myocardium compaction, and coronary vasculature defects, accompanied by reduced expression of epicardium genes. Cell adhesion gene expression and proepicardium outgrowth were defective in the ING4- and ING5-deficient state. Our findings suggest that ING4 and ING5 are essential for heart development and promote epicardium and epicardium-derived cell fates and imply mutation of the human ING5 gene as a possible cause of isolated ventricular septal defects.
Manual Interstructural Release Procedure Can Alter Muscle Shear Modulus
Authors: YAMASHITA TOMOKO , YOSHITAKE YASUHIDE , WATANABE HIRONORI , WASHINO SOHEI , GAMADA KAZUYOSHI , SHINOHARA MINORU 
Published: August 2024

ABSTRACT

Purpose
Interstructural release (ISR) procedure to skeletal muscles is believed to attenuate adhesion between neighboring muscles and alleviate subjective symptoms, including perceived stiffness and associated pain. However, objective evidence about the effect of ISR on the mechanical properties of the muscles is limited. The purpose of this study was to test the acute effect of ISR on the shear modulus of adjacent muscles. It was hypothesized that ISR applied to the border between synergistic muscles would acutely reduce the resting shear modulus of the involved muscle.

Methods
To assess the effect of ISR, the shear modulus of the resting peroneus longus (PL) and soleus (SOL) muscles was measured at various ankle joint positions (inversion/eversion) before and after interventions in nine nonsymptomatic male individuals (age: 21.9 ± 1.4 yr, height: 170 ± 6.6 cm, body mass: 64.3 ± 4.0 kg). Potential muscle activity during the measurement was assessed by recording surface electromyogram from these muscles. The interventions were ISR to the lower leg between the deep fascia of the PL and SOL and sham (massage).

Results
As the ankle joint position was passively varied toward inversion, the shear modulus increased substantially in PL and decreased moderately in SOL. Shear modulus of the proximal PL in the most inverted position increased acutely after ISR (by 11.4 ± 5.8%, P <0.001), but not after the sham, without any change in the amplitude of electromyogram.

Conclusions
These results provide objective evidence that the ISR procedure can acutely alter shear modulus, at least in a specific site in a resting muscle.
Baseline Symptoms and Neurocognitive Performance across Collision, Contact, and Noncontact Female High School Athletes
Authors: OLDHAM JESSIE R. , HOWELL DAVID R. , LANOIS COREY J. , BERKNER PAUL D. , IVERSON GRANT L. , MANNIX REBEKAH C. , MEEHAN WILLIAM P. 
Published: August 2024

ABSTRACT

Purpose
Our purpose was to represent a rare cohort of female collision sport athletes and investigate the association between sport type (collision, contact, and noncontact), symptoms, and performance on baseline neurocognitive assessments.

Methods
We conducted a cross-sectional study using baseline computerized neurocognitive scores (Immediate Postconcussion Assessment and Cognitive Testing [ImPACT]) of 75,128 female high school student-athletes (age, 15.27 ± 1.05 yr) playing multiple sports. The dependent variables were verbal memory, visual memory, visual motor speed, reaction time, and total symptom score. The independent variable was sport type, categorized as collision, contact, noncontact, adjusted for the effect of the following covariables: age, concussion history, and comorbidities (learning disability, ADHD, psychiatric condition, headaches, migraines, speech therapy, special education, and repeating one of more years of school) using multivariable regression models.

Results
Female collision sport athletes reported significantly higher symptoms (9.81 ± 12.63) at baseline compared with contact (5.78 ± 9.25) or noncontact (6.39 ± 9.74) sport athletes (P < 0.001). Using noncontact sports as a reference, there was no significant association between collision sport participation and cognitive composite scores (verbal memory: β = −0.57, 95% confidence interval = −1.80 to 0.66, P = 0.38; visual memory: β = −0.83, 95% confidence interval = −2.46 to 0.79, P = 0.31; visual motor speed: β = −0.21, 95% confidence interval = −1.01, 0.59, P = 0.61; reaction time: β = 0.01, 95% confidence interval = −0.01 to 0.02, P = 0.29).

Conclusions
Participation in collision sports appears to be associated with baseline symptoms but not neurocognitive functioning among female adolescent athletes.
Hypercongestion, Autonomous Vehicles, and Urban Spatial Structure
Authors: Dantsuji Takao , Takayama Yuki 
Published: August 2024

This paper examines the effects of hypercongestion mitigation by perimeter control and the introduction of autonomous vehicles on the spatial structures of cities. By incorporating a bathtub model, we develop a land use model where hypercongestion occurs in the downtown area and interacts with land use. We show that hypercongestion mitigation by perimeter control decreases the commuting cost in the short run and results in a less dense urban spatial structure in the long run. Furthermore, we reveal that the impact of autonomous vehicles depends on the presence of hypercongestion. The introduction of autonomous vehicles may increase the commuting cost in the presence of hypercongestion and may cause a decrease in the suburban population; however, it may make cities spatially expand outward. This result contradicts that of the standard bottleneck model. When perimeter control is implemented, the introduction of autonomous vehicles decreases the commuting cost and results in a less dense urban spatial structure. These results show that hypercongestion is a key factor that can change urban spatial structures. History: This paper has been accepted for the Transportation Science Special Issue on ISTTT25 Conference. Funding: This work was supported by ACT-X [Grant JPMJAX21AE], Fusion Oriented REsearch for disruptive Science and Technology [Grant JPMJFR215M], the Japan Society for the Promotion of Science [Grants 23K13422 and 22H01610], and the Council for Science, Technology and Innovation [Grant JPJ012187]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2024.0519 .