bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of cytotoxic CD8+ T‐lymphocyte deficiency in chronic rhinosinusitis patients: a demographic and functional study
Authors: Gabra Nathalie , Alromaih Saud , Endam Leandra Mfuna , Brito Rose Marie , Larivière Françoise , Al‐Mot Sawsan , LeDeist Françoise , Desrosiers Martin 
Published: March 2014

BackgroundIdentification of Staphylococcus aureus intracellularly in chronic rhinosinusitis (CRS) suggests an underlying cellular immunodeficiency. Supporting this, we have previously reported low CD8+ (cytotoxic) T‐lymphocyte levels in a subpopulation of CRS patients and identified polymorphisms in the CD8A gene associated with CRS. In order to better understand the role of low CD8+ in CRS, we wished to determine the phenotype for CRS/Low CD8+ in comparison to that of conventional CRS.MethodsSixty‐seven low CD8+ CRS patients identified during investigation of CRS were compared for demographics, disease evolution, and bacteriology on endoscopic culture were compared with an existing population of 480 patients with CRS with nasal polyposis previously recruited for genetic association studies.ResultsMean level of CD8+ in the CRS/Low CD8+ population was 0.15 × 109/L (range, 0.20–1.5 × 109/L). There was no difference between both groups in terms of history of allergy, asthma, eczema, acetylsalicylic acid (ASA) intolerance or smoking. The bacteriology was similar between both groups (S. aureus: CRS/Low CD8+: 35%; CRS 32%, p = 0.643). Evolution of disease was somewhat milder in CRS/Low CD8+, with fewer patients requiring surgery, and first surgery performed at a more advanced age. However, antibiotic use was higher in CRS/Low CD8+. Subgroup analysis restricted to CRS with nasal polyposis (CRSwNP)/Low CD8 or CRS without nasal polyposis (CRSsNP)/Low CD8 phenotypes did not substantially alter these results.ConclusionLow CD8+ levels are often identified in CRS patients; however, these patients have disease remarkably similar to those with conventional CRS. This suggests that immune deficiency, whether systemic or locally mediated, is well tolerated and may be present in other forms in CRS. CRS patients with low CD8+ levels may possibly require antibacterial therapies as part of ongoing management.
An Activatable Theranostic for Targeted Cancer Therapy and Imaging
Authors: Bhuniya Sankarprasad , Maiti Sukhendu , Kim Eun‐Joong , Lee Hyunseung , Sessler Jonathan L. , Hong Kwan Soo , Kim Jong Seung 
Published: March 2014

AbstractA new theranostic strategy is described. It is based on the use of an “all in one” prodrug, namely the biotinylated piperazine‐rhodol conjugate 4 a. This conjugate, which incorporates the anticancer drug SN‐38, undergoes self‐immolative cleavage when exposed to biological thiols. This leads to the tumor‐targeted release of the active SN‐38 payload along with fluorophore 1 a. This release is made selective as the result of the biotin functionality. Fluorophore 1 a is 32‐fold more fluorescent than prodrug 4 a. It permits the delivery and release of the SN‐38 payload to be monitored easily in vitro and in vivo, as inferred from cell studies and ex vivo analyses of mice xenografts derived from HeLa cells, respectively. Prodrug 4 a also displays anticancer activity in the HeLa cell murine xenograft tumor model. On the basis of these findings we suggest that the present strategy, which combines within a single agent the key functions of targeting, release, imaging, and treatment, may have a role to play in cancer diagnosis and therapy.
Rheological behavior ‐ Electrical and thermal properties of polypyrrole/graphene oxide nanocomposites
Authors: Manivel P. , Kanagaraj S. , Balamurugan A. , Ponpandian N. , Mangalaraj D. , Viswanathan C. 
Published: March 2014

ABSTRACTPolypyrrole/graphene oxide (Ppy/GO) nanocomposites were synthesized via in situ polymerization of pyrrole in the presence of GO at various proportions (1–5%). They were characterized to determine their electrical, thermal, and rheological properties by various techniques. The aim of this study was to determine the rheological behavior of Ppy/GO nanocomposite at different mass ratios (100 : 1, 100 : 2, 100 : 3, 100 : 4, and 100 : 5%) and temperature (25–180°C) using a rotational mode in cone‐plate method. The shear stress (τ Pa) and viscosity (η Pa s) values of the nanocomposites increased with the increase in GO mass ratio added to Ppy, which was accompanied by an increased flexibility of the nanocomposites due to the higher aspect ratio of the GO sheet. Hence, it is suggested that the GO sheets are effective for the reinforcement of Ppy thereby significantly improvising its thermal stability, electrical conductivity, and rheological properties. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40642.
Active Disturbance Rejection Control for Piezoelectric Beam
Authors: Zheng Qinling , Richter Hanz , Gao Zhiqiang 
Published: March 2014

AbstractPiezoelectric beam dynamics are characterized by elastic properties, nonlinearities, uncertainties, and unknown disturbances, thus making vibration suppression a challenging control problem. To meet this challenge, a novel active control method has been designed and rigorously tested on actual hardware without the requirement of extensive modeling. In this unique approach, the piezoelectric beam dynamics, known or unknown, linear or nonlinear, and all external disturbances are treated in their totality as an input disturbance which is subsequently estimated and canceled in real time, reducing the challenging problem to a very manageable one. Simulation and experimental results demonstrate the effectiveness of this practical control method. The frequency domain characteristics of the proposed method are analyzed using Bode and describing function methods.
On the Stabilization of Linear Time Invariant Fractional Order Commensurate Switched Systems
Authors: Balochian Saeed 
Published: March 2014

AbstractIn this paper, the stabilization problem of a linear time invariant fractional order (LTI‐FO) switched system is outlined. First, the sufficient condition for stability of a commensurate LTI‐FO switched system based on the convex analysis and linear matrix inequality (LMI) is presented. Then, a single Lyapunov function is constructed based on the optimization method. Then, a sliding sector is designed for each subsystem of the LTI‐FO switched system so that each state in the state space is inside at least one sliding sector with its corresponding subsystem, where the Lyapunov function found by the optimization method is decreasing. Finally, a switching control law is designed to switch the LTI‐FO switched system among subsystems to ensure the decrease of the Lyapunov function in the state space. Simulation results are given to show the effectiveness of the proposed variable structure controller.
FAULT DIAGNOSIS OF HYDRAULIC SERVO SYSTEM USING THE UNSCENTED KALMAN FILTER
Authors: Liu Hongmei , Liu Dawei , Lu Chen , Wang Xuan 
Published: March 2014

AbstractFault occurrence can be embodied by the physical parameter variations of the hydraulic servo system. Faults can, therefore, be diagnosed according to the model coefficient variations of the hydraulic servo system. This paper proposes an approach for fault diagnosis based on the unscented Kalman filter (UKF) with a mathematical model of the hydraulic servo system. The mathematical model is established using the dynamic equations of the hydraulic servo system. Based on the fault mechanism analysis results, several important system model parameters that can separately represent different faults in different components of the hydraulic servo system are chosen. Discrete state space equations are derived from the dynamic equations. The UKF algorithm is used to estimate the important system model parameters of the hydraulic servo system by utilizing the discretized state space model. According to the variations of these model parameters, the fault modes and locations of the hydraulic servo system can be diagnosed and isolated. Two types of faults, namely, abrupt fault in servovalve gain and slow wear fault in hydraulic cylinder piston, which cannot be directly detected from the system output, are introduced individually to the hydraulic servo system in this work. By comparing with the extended Kalman Filter, three different experimental cases are used to validate the effectiveness of the UKF for hydraulic servo system fault diagnosis.
Seasonality of congenital anomalies in Europe
Authors: Luteijn Johannes Michiel , Dolk Helen , Addor Marie‐Claude , Arriola Larraitz , Barisic Ingeborg , Bianchi Fabrizio , Calzolari Elisa , Draper Elizabeth , Garne Ester , Gatt Miriam , Haeusler Martin , Khoshnood Babak , McDonnell Bob , Nelen Vera , O'Mahony Mary , Mullaney Carmel , Queisser‐Luft Annette , Rankin Judith , Tucker David , Verellen‐Dumoulin Christine , de Walle Hermien , Yevtushok Lyubov 
Published: March 2014

BackgroundThis study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. Methods: Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population‐based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. Results: We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. Conclusion: We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. Birth Defects Research (Part A) 100:260–269, 2014. © 2014 Wiley Periodicals, Inc.
Analysis of immunocytochemical and molecular BRAF expression in thyroid carcinomas: A cytohistologic institutional experience
Authors: Rossi Esther Diana , Martini Maurizio , Capodimonti Sara , Cenci Tonia , Straccia Patrizia , Angrisani Basilio , Ricci Costantino , Lanza Paola , Lombardi Celestino Pio , Pontecorvi Alfredo , Larocca Luigi Maria , Fadda Guido 
Published: March 2014

BACKGROUNDIt has been generally demonstrated that the valine‐to‐glutamic acid substitution at position 600 (V600E) in the v‐Raf murine sarcoma viral oncogene homolog B1 (BRAF) gene is an effective diagnostic/prognostic marker mainly for papillary thyroid carcinoma (PTC). The detection of this mutation typically has been achieved using DNA‐based techniques. The recently introduced monoclonal V600E antibody (clone VE1) is likely to be an alternative strategy for detecting this mutation in thyroid lesions. The authors investigated molecular and immunocytohistochemical BRAF analyses in a prospective series of samples from patients with PTC.METHODSFifty‐five prospective cytohistologic samples that were diagnosed as PTC were studied using both DNA BRAF testing and the VE1 antibody. The intensity of VE1 expression was graded from 0 (negative) to 3+ (strong).RESULTSAll diagnoses were histologically confirmed. In total, 37 samples with mutated BRAF and 18 samples with wild‐type BRAF were reported with 100% cytohistologic concordance. Cytologic VE1 expression revealed 25 negative samples (including 16 with 0 expression and 9 with 1+ expression) and 30 positive samples (including 16 with 2+ expression and 14 with 3+ expression). On histology, there were 27 negative samples (20 with 0 expression and 7 with 1+ expression) and 28 positive samples (14 with 2+ expression and 14 with 3+ expression). Four specimens with the BRAF mutation had discrepancies in VE1 intensity between cytology and histology. Furthermore, 6 BRAF‐mutated samples produced negative VE1 results.CONCLUSIONSAlthough it has limitations, the VE1 antibody represents a feasible first‐line approach for evaluating BRAF mutation status and may be a valid tool in the selection of samples for molecular analysis. The current report highlights the statistically significant difference between molecular and VE1 positivity in PTC (P < .0001). Nevertheless, in the authors' experience, BRAF mutations are more accurate for identifying VE1‐negative cases. Cancer (Cancer Cytopathol) 2014;122:527–535. © 2014 American Cancer Society.
Usefulness and limitations of contractile reserve evaluation in patients with low‐flow, low‐gradient aortic stenosis eligible for cardiac resynchronization therapy
Authors: Garnier Fabien , Eicher Jean‐Christophe , Jazayeri Saed , Bertaux Géraldine , Bouchot Olivier , Aho Ludwig‐Serge , Wolf Jean‐Eric , Laurent Gabriel 
Published: March 2014

AimsIn low‐flow, low‐gradient aortic stenosis (LF/LG AS), the assessment of contractile reserve (CR) by dobutamine stress echocardiography (DSE) is recommended for risk stratification and treatment strategy. However, DSE may show limitations in cases of left ventricular dyssynchrony (LVD). The impact of LVD in LF/LG AS, and the feasibility of CRT in this setting have never been evaluated. We aimed to assess: (i) the proportion of LF/LG AS patients with LVD; (ii) the influence of LVD on CR at DSE; and (iii) the effects of CRT in these patients.Methods and resultsThirty consecutive patients with LF/LG AS underwent DSE with study of CR. The operative risk for aortic valve replacement (AVR) was assessed using the logistic EuroSCORE. Twenty‐one of the 30 patients had LVD. They were significantly older, more symptomatic, had a higher EuroSCORE, and a lower prevalence of CR than those with a narrow QRS (47% vs. 100%, P = 0.009). A CRT pacemaker was implanted in 19 of the 21 patients with LVD. All 19 (except for one patient who died suddenly) experienced significant clinical and echocardiographic improvement. Fourteen CRT patients underwent subsequent AVR with a low event rate. Four CRT patients refused AVR; two of them worsened again 1–2 years post‐CRT.ConclusionLVD is common in LF/LG AS patients and may be a major mechanism of afterload mismatch, as well as a cause of underdetection of CR. CRT in this population is feasible and may be proposed as a bridge to surgery.
Gold(I)‐Catalyzed Hydration of Alkynylphosphonates: Efficient Access to β‐Ketophosphonates
Authors: Xie Longyong , Yuan Rui , Wang Ruijia , Peng Zhihong , Xiang Jiannan , He Weimin 
Published: March 2014

AbstractA general, efficient, and highly regioselective protocol with the use of a gold(I) complex catalytic system for the transformation of alkynylphosphonates into the corresponding β‐ketophosphonates has been successfully developed. This method produces a variety of β‐ketophosphonates with the advantages of mild reaction conditions, high functional‐group tolerance, and excellent yields.
Mannich‐Type Addition Reactions between Lithium Derivatives of Benzo[d]thiazoles and N‐tert‐Butylsulfinyl‐3,3,3‐trifluoroacetaldimine: Convenient Generalized Synthesis of Bis(benzothiazole)s
Authors: Mei Haibo , Dai Yanling , Wu Lingmin , Soloshonok Vadim A. , Han Jianlin , Pan Yi 
Published: March 2014

AbstractThis study describes the anomalous outcome of the Mannich‐type reaction of N‐tert‐butylsulfinyl‐3,3,3‐trifluoroacetaldimine and Li derivatives of benzo[d]thiazoles, which offers a convenient and generalized method for the synthesis of biologically relevant (E)‐1,2‐bis(2‐benzothiazolyl)ethanes. The mechanism, scope, and scalability of this new reaction are discussed.
Efficient Synthesis of Dihydropyrazoles by Halocyclization of β,γ‐Unsaturated Hydrazones
Authors: Hu Xiao‐Qiang , Chen Jia‐Rong , Wei Qiang , Liu Feng‐Lei , Deng Qiao‐Hui , You‐Quan Zou  , Xiao Wen‐Jing 
Published: March 2014

AbstractAn efficient halocyclization of β,γ‐unsaturated hydrazones with N‐bromosuccinimide was developed without the addition of any additives under mild reaction conditions to provide facile access to biologically important 4,5‐dihydropyrazoles. Under the optimized conditions, a variety of highly substituted 4,5‐dihydropyrazole derivatives were obtained in generally good yields. Moreover, this reaction can be further applied to the synthesis of pyrazoles in a one‐pot fashion.
Disorder and damage of base‐isolated medical facilities when subjected to near‐fault and long‐period ground motions
Authors: Shi Yundong , Kurata Masahiro , Nakashima Masayoshi 
Published: March 2014

SUMMARYA series of full‐scale shaking table tests were conducted at E‐Defense for a four‐story base‐isolated hospital. The operation room in the specimen was chosen for detailed examination of its disorder and damage during large ground motions. It was arranged with various medical appliances in as a realistic manner as possible, and the appliances were characterized by casters installed at the bottom to ensure mobility. Two types of ground motion, the near‐fault ground motion and long‐period ground motion, were adopted, and the responses of the appliances were recorded using the motion capture technique. Thanks to the base isolation, the floor response was greatly reduced, and no disorder or damage was observed in the operation room except for the case when subjected to a long‐period ground motion. In this case, the unlocked appliances moved seriously (by more than 3 m), and collisions occurred between the appliances and between appliances and the surrounding wall. The force of collision reached 36 kN, which is sufficient to injure a person. The acceleration due to collision was as high as 10 g, which is far beyond what can be tolerated by acceleration‐sensitive appliances. It is notable that such large motion was not observed once the appliances were locked. The test was also carried out for the corresponding fixed‐base structure. Among all cases in the experiment, by far the most serious damage occurred in the fixed‐base structure when subjected to the near‐fault ground motion, clearly because the floor response was significantly amplified from the ground motion. Copyright © 2014 John Wiley & Sons, Ltd.
Low‐density parity‐check and fountain code performance over mobile wireless optical channels
Authors: Barbot N. , Sahuguede S. , Julien‐Vergonjanne A. , Cances J.P. 
Published: March 2014

ABSTRACTBy considering error control in different layers, the efficiency of several mechanisms is discussed in the context of wireless optical transmission of mobile health care application data. In this respect, we assume an emitter placed on a monitored patient and a fixed receiver. Because of patient mobility and health care data rate, the wireless optical channel is fading slowly. To ensure reliable communication, we study in the physical layer the low‐density parity‐check code performance by analysing the results in terms of outage probability. Concerning the application layer, we explore fountain codes, which are also known as Luby transform codes, together with an automatic repeat request mechanism by determining the related outage capacity. Taking into account the performance of both layers, we show that it is possible to design the physical layer code rate in that we maximise the effective data rate in the application layer. Moreover, we point out that Luby transform and low‐density parity‐check codes constitute an efficient and robust mechanism to reduce optical emitted power, which is of main concern for health care application. Copyright © 2014 John Wiley & Sons, Ltd.
Neural substrates of numerosity estimation in autism
Authors: Meaux Emilie , Taylor Margot J. , Pang Elizabeth W. , Vara Anjili S. , Batty Magali 
Published: March 2014

AbstractVisual skills, including numerosity estimation are reported to be superior in autism spectrum disorders (ASD). This phenomenon is attributed to individuals with ASD processing local features, rather than the Gestalt. We examined the neural correlates of numerosity estimation in adults with and without ASD, to disentangle perceptual atypicalities from numerosity processing. Fourteen adults with ASD and matched typically developed (TD) controls estimated the number of dots (80–150) arranged either randomly (local information) or in meaningful patterns (global information) while brain activity was recorded with magnetoencephalography (MEG). Behavioral results showed no significant group difference in the errors of estimation. However, numerical estimation in ASD was more variable across numerosities than TD and was not affected by the global arrangement of the dots. At 80–120 ms, MEG analyses revealed early significant differences (TD > ASD) in source amplitudes in visual areas, followed from 120 to 400 ms by group differences in temporal, and then parietal regions. After 400 ms, a source was found in the superior frontal gyrus in TD only. Activation in temporal areas was differently sensitive to the global arrangement of dots in TD and ASD. MEG data show that individuals with autism exhibit widespread functional abnormalities. Differences in temporal regions could be linked to atypical global perception. Occipital followed by parietal and frontal differences might be driven by abnormalities in the processing and conversion of visual input into a number‐selective neural code and complex cognitive decisional stages. These results suggest overlapping atypicalities in sensory, perceptual and number‐related processing during numerosity estimation in ASD. Hum Brain Mapp 35:4362–4385, 2014. © 2014 Wiley Periodicals, Inc.
Functional brain networks and cognitive deficits in Parkinson's disease
Authors: Baggio Hugo‐Cesar , Sala‐Llonch Roser , Segura Bàrbara , Marti Maria‐José , Valldeoriola Francesc , Compta Yaroslau , Tolosa Eduardo , Junqué Carme 
Published: March 2014

AbstractGraph‐theoretical analyses of functional networks obtained with resting‐state functional magnetic resonance imaging (fMRI) have recently proven to be a useful approach for the study of the substrates underlying cognitive deficits in different diseases. We used this technique to investigate whether cognitive deficits in Parkinson's disease (PD) are associated with changes in global and local network measures. Thirty‐six healthy controls (HC) and 66 PD patients matched for age, sex, and education were classified as having mild cognitive impairment (MCI) or not based on performance in the three mainly affected cognitive domains in PD: attention/executive, visuospatial/visuoperceptual (VS/VP), and declarative memory. Resting‐state fMRI and graph theory analyses were used to evaluate network measures. We have found that patients with MCI had connectivity reductions predominantly affecting long‐range connections as well as increased local interconnectedness manifested as higher measures of clustering, small‐worldness, and modularity. The latter measures also tended to correlate negatively with cognitive performance in VS/VP and memory functions. Hub structure was also reorganized: normal hubs displayed reduced centrality and degree in MCI PD patients. Our study indicates that the topological properties of brain networks are changed in PD patients with cognitive deficits. Our findings provide novel data regarding the functional substrate of cognitive impairment in PD, which may prove to have value as a prognostic marker. Hum Brain Mapp 35:4620–4634, 2014. © 2014 Wiley Periodicals, Inc.