bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostatakarzinom-Screening? Nur evidenzbasiert, risikoadaptiert und organisiert!
Authors: Albers Peter , Becker Nikolaus 
Published: August 2024

ZusammenfassungAufgrund einer Kommissionsempfehlung der Europäischen Union aus dem Jahr 2022, neue Screeningstrategien für das Bronchialkarzinom, das Magenkarzinom und das Prostatakarzinom zu entwickeln, ist auch Deutschland dazu aufgerufen, sein Prostatakarzinom-Früherkennungsprogramm zu überarbeiten. In diesem Diskussionsartikel wird eine Übersicht über neue Ergebnisse zur Prostatakrebsfrüherkennung gegeben, die auf die Empfehlung eines organisierten, risikoangepassten Prostatakrebsscreenings hinauslaufen. Basierend auf den ersten Resultaten der aktuellen deutschen Prostatascreening-Studie PROBASE und neuer internationaler Literatur sollten Modellprojekte begonnen werden, die die spezifischen Bedingungen für ein organisiertes risikoadaptiertes Prostatakarzinom-Screeningprogramm erkunden.
Experimental investigations on the behaviour of structural-sized wood-CFRP composite beams in local fire
Authors: Kawecki Bartosz , Pieńko Michał , Lipecki Tomasz , Stachowicz Andrzej 
Published: August 2024

AbstractThe study involved combustion of 24 structural-sized beams under three-point bending subjected to substantial loading prior to ignition, reaching 90% of characteristic load-carrying capacity. A localised fire exposure zone was established proximal to the region experiencing the highest bending moment. The specimens were categorised into two groups: the first consisted of tituted by glued-laminated timber (B), and the second comprised wood-CFRP (carbon fibre reinforced polymer) composite (BW). Initial measurements encompassed pre-ignition static deflection and load. Subsequently, the specimens underwent controlled combustion, during which parameters including burning duration and deflection up to failure, were documented. Following cooling with sand, two cross-sectional slices were extracted from each fractured beam, enabling to find vector-based contours of the remaining cross-section. The charring rate and the approximate heat flux density for each test were determined, enabling a direct comparison of the results. A statistically significant number of specimens was examined, facilitating a comparative analysis between reinforced and unreinforced beams concerning failure time and form. Incorporating CFRP tapes among wooden constituents was found to increase the fire resistance of the structure, however, the thickness of the wooden material enveloping the CFRP composite emerges as a pivotal determinant. This issue needs thorough testing under standard fire in the future. Nevertheless, the fact is that adding CFRP tapes engenders a distinct form of beam collapse, transitioning from instantaneous cracking in B-beams to ductile failure in BW-beams.
A review of inverse problems for generalized elastic media: formulations, experiments, synthesis
Authors: Fedele Roberto , Placidi Luca , Fabbrocino Francesco 
Published: August 2024

AbstractStarting from the seminal works of Toupin, Mindlin and Germain, a wide class of generalized elastic models have been proposed via the principle of virtual work, by postulating expressions of the elastic energy enriched by additional kinematic descriptors or by higher gradients of the placement. More recently, such models have been adopted to describe phenomena which are not consistent with the Cauchy-Born continuum, namely the size dependence of apparent elastic moduli observed for micro and nano-objects, wave dispersion, optical modes and band gaps in the dynamics of heterogeneous media. For those structures the mechanical response is affected by surface effects which are predominant with respect to the bulk, and the scale of the external actions interferes with the characteristic size of the heterogeneities. Generalized continua are very often referred to as media with microstructure although a rigorous deduction is lacking between the specific microstructural features and the constitutive equations. While in the forward modelling predictions of the observations are provided, the actual observations at multiple scales can be used inversely to integrate some lack of information about the model. In this review paper, generalized continua are investigated from the standpoint of inverse problems, focusing onto three topics, tightly connected and located at the border between multiscale modelling and the experimental assessment, namely: (i) parameter identification of generalized elastic models, including asymptotic methods and homogenization strategies; (ii) design of non-conventional tests, possibly integrated with full field measurements and advanced modelling; (iii) the synthesis of meta-materials, namely the identification of the microstructures which fit a target behaviour at the macroscale. The scientific literature on generalized elastic media, with the focus on the higher gradient models, is fathomed in search of questions and methods which are typical of inverse problems theory and issues related to parameter estimation, providing hints and perspectives for future research.
Contractile effects of stimulation of D1-dopamine receptors in the isolated human atrium
Authors: Gergs U. , Pham T. H. , Rayo Abella L. M. , Hesse C. , Grundig P. , Dhein S. , Hofmann B. , Neumann J. 
Published: August 2024

Abstract
Dopamine receptors have been claimed not to directly increase contractility in the human heart. Therefore, we performed contraction experiments in isolated electrically driven human atrial preparations (HAP). For comparison, we performed contraction experiments with left atrial preparations of transgenic mice which harbor a cardiac overexpression of human D1-dopamine receptors (D1-TG). In D1-TG, first we noted that dopamine (10 nM–10 µM cumulatively applied) in the presence of propranolol exerted a concentration- and time-dependent positive inotropic effect in D1-TG. In a similar fashion, dopamine increased force of contraction in the presence of 0.4 µM propranolol in HAP and these effects were amplified by pre-treatment with inhibitor of phosphodiesterase III (1 µM) cilostamide. Moreover, contractile effects of dopamine in the presence of propranolol 0.4 µM in HAP were antagonized by odapipam, haloperidol, or raclopride. Ten micromolars of fenoldopam in the presence of cilostamide increased force of contraction in HAP and this effect was antagonized by SCH 23390. We conclude that stimulation of human D1-dopamine receptors can increase force of contraction in the HAP.
The effects of N-acetyl cysteine on intrinsic functional connectivity and neural alcohol cue reactivity in treatment-seeking individuals with alcohol use disorder: a preliminary study
Authors: Logge Warren B , Haber Paul S , Hurzeler Tristan P , Towers Ellen E , Morley Kirsten C 
Published: August 2024

Abstract
N-acetyl cysteine (NAC) is a potential pharmacotherapy for alcohol use disorder (AUD), but it is not known whether it modulates neural activation to alcohol cues or intrinsic functional connectivity. We investigated whether NAC attenuates (i) alcohol cue-elicited activation, and (ii) intrinsic functional connectivity compared to placebo in patients with AUD. In this preliminary study, twenty-three individuals (7 females) with moderate-severe AUD received daily NAC (2400 mg/day, n = 9), or a placebo (n = 14) for at least 2 weeks. Participants completed a pre-treatment functional magnetic resonance imaging session (T0) and a post-treatment session (T1) comprising resting-state and visual alcohol cue reactivity task acquisitions. Activation differences between sessions, treatment, and session-by-treatment interaction were assessed. Resting-state functional connectivity examined using 377 node ROI-to-ROIs evaluated whether NAC reduced intrinsic functional connectivity after treatment. There were no differences in alcohol cue reactivity for brain activation or subjective craving between NAC and placebo during treatment or across sessions, or significant interaction. A significant treatment-by-time interaction, with reduced intrinsic connectivity was observed after treatment (T1) for NAC-treated compared to placebo-treated patients in the posterior cingulate node (9, left hemisphere) of the dorsal attentional network and connections to salience, ventral-attentional, somatosensory, and visual-peripheral networks implicated in AUD. NAC reduced intrinsic functional connectivity in patients with moderate-severe AUD after treatment compared to placebo, but did not attenuate alcohol cue-elicited activation. However, the absence of cue reactivity findings may result from low power, rather than the absence of cue reactivity findings associated with NAC. These results provide preliminary evidence that NAC treatment may modulate intrinsic functional connectivity brain activation in patients with alcohol use disorder, but replication in larger studies are required to determine the strength of this effect and any associations with clinical outcomes.

Clinical Trials Registration: ClinicalTrials.gov Identifier: NCT03879759.
Snail shell shape, force of attachment, and metabolic rate together cope with the intertidal challenge
Authors: Alcaraz Guillermina , Alvarez-Galicia Aldair , Ramírez-Sánchez Marcia M. , Burciaga Luis M. 
Published: August 2024

AbstractInhabitants of rocky intertidal shores, including gastropods, require specific adaptations to cope with numerous challenges that vary across the intertidal levels. We collected Stramonita biserialis snails from upper (wave-protected and intense predation) and lower (wave-exposed and low predation) intertidal sites to compare the following traits: shell skeleton (ventral and abaxial lateral views of shell shape, thickness, and mass), foot size, energy metabolism, and attachment strength to determine whether the trait values of snails from each zone fit the environmental challenges they face. We used a Principal Component Analysis to reduce the dimensionality of the data. Multivariate Analysis of Covariance (MANCOVA) for comparing characteristics between the two intertidal zones, and Partial Least Squares (PLS) analyses for testing the integration of overall snail characteristics. The traits of the snails of the two intertidal sites matched with the adaptations expected to allow them to cope with their contrasting challenges. The snails from the lower intertidal had more streamlined shells (which reduces drag forces) and a larger aperture and foot extension (which increase the strength of their attachment to the substrate) compared to snails from the upper sites. Snails from the lower intertidal also had a high mass-specific metabolism and soft body proportion, indicating that these snails from the wave-exposed sites have an energetically active musculature that matches their strong substrate attachment. The thin shell walls of the snails of the lower intertidal match the relatively low predatory pressure there.
Decentralized pure exchange processes on networks
Authors: Cassese Daniele , Pin Paolo 
Published: August 2024

AbstractWe define a class of pure exchange Edgeworth trading processes that under minimal assumptions converge to a stable set in the space of allocations, and characterise the Pareto set of these processes. Choosing a specific process belonging to this class, that we define fair trading, we analyse the trade dynamics between agents located on a weighted network. We determine the conditions under which there always exists a one-to-one map between the set of networks and the set of limit points of the dynamics, and derive an analog of the Second Welfare Theorem for networks. This result is used to explore what is the effect of the network topology on the trade dynamics and on the final allocation.
Animal and organoid models to elucidate the anti-fibrotic effect of steroid on biliary atresia
Authors: Liu Fangran , Lui Vincent Chi Hang , Wu Zhongluan , Blakeley Paul David , Tang Clara Sze Man , Tam Paul Kwong Hang , Wong Kenneth Kak Yuen , Chung Patrick Ho Yu 
Published: August 2024

Abstract
Purpose
We performed animal and organoid study to evaluate the anti-fibrotic effect of steroid on biliary atresia (BA) and the underlying patho-mechanism.

Methods
BA animal models were created by inoculation of mice on post-natal day 1 with rhesus rotavirus (RRV). They received either 20 µl phosphate-buffered saline (PBS) or steroid from day 21 to day 34. On day 34, their serum samples were collected for hormonal markers. Necrosis, fibrosis and CK 19 expression in the liver were evaluated. Liver organoids were developed and their morphology as well as bulk RNA sequencing data were analyzed.

Results
Twenty-four mice developed BA features after RRV injection and were equally divided into steroid and PBS groups. On day 34, the weight gain of steroid group increased significantly than PBS group (p < 0.0001). All mice in the PBS group developed liver fibrosis but only one mouse in the steroid group did. Serum bilirubin and liver parenchymal enzymes were significantly lower in steroid group. The morphology of liver organoids were different between the two groups. A total of 6359 differentially expressed genes were found between steroid group and PBS group.

Conclusion
Based on our findings obtained from RRV-induced BA animal and organoid models, steroid has the potential to mitigate liver fibrosis in BA.
Angiography-derived physiological patterns of coronary artery disease: implications with post-stenting physiology and long-term clinical outcomes
Authors: Fezzi Simone , Del Sole Paolo Alberto , Burzotta Francesco , Leone Antonio Maria , Ding Daixin , Terentes-Printzios Dimitrios , Trani Carlo , Bonizzi Luca , Sgreva Sara , Andreaggi Stefano , Huang Jiayue , Pesarini Gabriele , Tavella Domenico , Prado Guy , Vicerè Andrea , Oikonomou Dimitrios , Gkini Konstantia Paraskevi , Galante Domenico , Tsioufis Konstantinos , Vlachopoulos Charalambos , Wijns William , Ribichini Flavio , Tu Shengxian , Scarsini Roberto 
Published: August 2024

Abstract
Background
Physiological patterns of coronary artery disease (CAD) have emerged as potential determinants of functional results of percutaneous coronary interventions (PCI) and of vessel-oriented clinical outcomes (VOCE).

Objectives
In this study, we evaluated the impact of angiography-derived physiological patterns of CAD on post-PCI functional results and long-term clinical outcomes.

Methods
Pre-PCI angiography-derived fractional flow reserve (FFR) virtual pullbacks were quantitatively interpreted and used to determine the physiological patterns of CAD. Suboptimal post-PCI physiology was defined as an angiography-derived FFR value ≤ 0.91. The primary endpoint was the occurrence of VOCE at the longest available follow-up.

Results
Six hundred fifteen lesions from 516 patients were stratified into predominantly focal (n = 322, 52.3%) and predominantly diffuse (n = 293, 47.7%). Diffuse pattern of CAD was associated with lower post-PCI angiography-derived FFR values (0.91 ± 0.05 vs. 0.94 ± 0.05; p = 0.001) and larger rate of suboptimal post-PCI physiology (43.0 vs. 22.7%; p = 0.001), as compared to focal CAD. At the median follow-up time of 37 months (33–58), post-PCI suboptimal physiology was related to a higher risk of VOCE (16.2% vs. 7.6%; HR: 2.311; 95% CI 1.410–3.794; p = 0.0009), while no significant difference was noted according to baseline physiological pattern. In diffuse disease, the use of intracoronary imaging was associated with a lower incidence of long-term VOCE (5.1% vs 14.8%; HR: 0.313, 95% CI 0.167–0.614, p = 0.030).

Conclusions
Suboptimal post-PCI physiology is observed more often in diffusely diseased arteries and it is associated with higher risk of VOCE at follow-up. The use of intravascular imaging might improve clinical outcomes in the setting of diffuse CAD.
Echocardiographic assessment of left ventricular volumes: a comparison of different methods in athletes
Authors: Kandels Joscha , Denk Verena , Pedersen Maria Weinkouff , Kragholm Kristian Hay , Søgaard Peter , Tayal Bhupendar , Marshall Robert Percy , Denecke Timm , Lindgren Filip Lyng , Hagendorff Andreas , Stöbe Stephan 
Published: August 2024

Abstract
Background
Cardiac magnetic resonance imaging (cMRI) is considered the gold standard for the assessment of left ventricular (LV) systolic function. However, discrepancies have been reported in the literature between LV volumes assessed by transthoracic echocardiography (TTE) and cMRI. The objective of this study was to analyze the differences in LV volumes between different echocardiographic techniques and cMRI.

Methods and results
In 64 male athletes (21.1 ± 4.9 years), LV volumes were measured by TTE using the following methods: Doppler echocardiography, anatomical M-Mode, biplane/triplane planimetry and 3D volumetry. In addition, LV end-diastolic (LVEDV), end-systolic (LVESV), and stroke volumes (LVSV) were assessed in 11 athletes by both TTE and cMRI. There was no significant difference between LVEDV and LVESV determined by biplane/triplane planimetry and 3D volumetry. LVEDV and LVESV measured by M-Mode were significantly lower compared to 3D volumetry. LVSV determined by Doppler with 3D planimetry of LV outflow tract was significantly higher than 2D planimetry and 3D volumetry, whereas none of the planimetric or volumetric methods for determining LVSV differed significantly. There were no significant differences for LVEDV, LVESV, LVSV and LVEF between cMRI and TTE determined by biplane planimetry in the subgroup of 11 athletes.

Conclusion
The choice of echocardiographic method used has an impact on LVSV in athletes, so the LVSV should always be checked for plausibility. The same echocardiographic method should be used to assess LVSV at follow-ups to ensure good comparability. The data suggest that biplane LV planimetry by TTE is not inferior to cMRI.
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Authors: Bunse Till , Ziel Anne , Hagen Philipp , Rigopoulos George , Yasar Umit , Inan Hakan , Köse Gurbet , Eigner Ulrich , Kaiser Rolf , Bardeck Nils , Köffer Jasmin , Kolb Melissa , Ren Xiaomei , Tan Deyong , Dai Lizhong , Protzer Ulrike , Wettengel Jochen M. 
Published: August 2024

AbstractOutbreaks of emerging diseases, like Mpox in 2022, pose unprecedented challenges to global healthcare systems. Although Mpox cases globally decreased since the end of 2022, numbers are still significant in the African Region, European Region, Region of the Americas, and Western Pacific Region. Rapid and efficient detection of infected individuals by precise screening assays is crucial for successful containment. In these assays, analytical and clinical performance must be assessed to ensure high quality. However, clinical studies evaluating Mpox virus (MPXV) detection kits using patient-derived samples are scarce. This study evaluated the analytical and clinical performance of a new diagnostic MPXV real-time PCR detection kit (Sansure Monkeypox Virus Nucleic Acid Diagnostic Kit) using patient-derived samples collected in Germany during the MPXV clade IIb outbreak in 2022. Our experimental approach determined the Limit of Detection (LoD) to less than 200 cp/mL using whole blood samples and samples derived from vesicles or pustules. Furthermore, we tested potentially inhibiting substances and pathogens with homologous nucleic acid sequences or similar clinical presentation and detected no cross-reactivity or interference. Following this, the assay was compared to a CE-marked test in a clinical performance study and achieved a diagnostic sensitivity of 100.00% and diagnostic specificity of 96.97%. In summary, the investigated real-time PCR assay demonstrates high analytical performance and concurs with the competitor device with high specificity and sensitivity.
The influence of air masses on human mortality in the contiguous United States
Authors: Lee Cameron C. , Silva Alindomar , Ibebuchi Chibuike , Sheridan Scott C. 
Published: August 2024

AbstractTemperature-related mortality is the leading cause of weather-related deaths in the United States. Herein, we explore the effect of air masses (AMs) – a relatively novel and holistic measure of environmental conditions – on human mortality across 61 cities in the United States. Geographic and seasonal differences in the effects of each AM on deseasonalized and detrended anomalous lagged mortality are examined using simple descriptive statistics, one-way analyses of variance, relative risks of excess mortality, and regression-based artificial neural network (ANN) models. Results show that AMs are significantly related to anomalous mortality in most US cities, and in most seasons. Of note, two of the three cool AMs (Cool and Dry-Cool) each show a strong, but delayed mortality response in all seasons, with peak mortality 2 to 4 days after they occur, with the Dry-Cool AM having nearly a 15% increased risk of excess mortality. Humid-Warm (HW) air masses are associated with increases in deaths in all seasons 0 to 1 days after they occur. In most seasons, these near-term mortality increases are offset by reduced mortality for 1–2 weeks afterwards; however, in summer, no such reduction is noted. The Warm and Dry-Warm AMs show slightly longer periods of increased mortality, albeit slightly less intensely as compared with HW, but with a similar lag structure by season. Meanwhile, the most seasonally consistent results are with transitional weather, whereby passing cold fronts are associated with a significant decrease in mortality 1 day after they occur, while warm fronts are associated with significant increases in mortality at that same lag time. Finally, ANN modeling reveals that AM-mortality relationships gleaned from a combined meta-analysis can actually lead to more skillful modeling of these relationships than models trained on some individual cities, especially in the cities where such relationships might be masked due to low average daily mortality.
Daily sunshine grids for Austria since 1961 – combining station and satellite observations for a multi-decadal climate-monitoring dataset
Authors: Hiebl Johann , Bourgeois Quentin , Tilg Anna-Maria , Frei Christoph 
Published: August 2024

AbstractGrid datasets of sunshine duration at high spatial resolution and extending over many decades are required for quantitative applications in regional climatology and environmental change (e.g., modelling of droughts and snow/ice covers, evaluation of clouds in numerical models, mapping of solar energy potentials). We present a new gridded dataset of relative (and derived absolute) sunshine duration for Austria at a grid spacing of 1 km, extending back until 1961 at daily time resolution. Challenges in the dataset construction were consistency issues in the available station data, the scarcity of long time series, and the high variation of cloudiness in the study region. The challenges were addressed by special efforts to correct evident breaks in the station series and by adopting an analysis method, which combines station data with satellite data. The methodology merges the data sources non-contemporaneously, using statistical patterns distilled over a short period, which allowed involving satellite data even for the early part of the study period. The resulting fields contain plausible mesoscale structures, which could not be resolved by the station network alone. On average, the analyses explain 47% of the spatial variance in daily sunshine duration at the stations. Evaluation revealed a slight systematic underestimation (− 1.5%) and a mean absolute error of 9.2%. The average error is larger during winter, at high altitudes, and around the 1990s. The dataset exhibits a conditional bias, which can lead to considerable systematic errors (up to 15%) when calculating sunshine-related climate indices.