bluuebunny/crossref_metadata_2025_split huggingface dataset:
International experience for laparoscopic major liver resection
Authors: Dagher Ibrahim , Gayet Brice , Tzanis Dimitrios , Tranchart Hadrien , Fuks David , Soubrane Olivier , Han Ho‐Seong , Kim Ki‐Hun , Cherqui Daniel , O'Rourke Nicholas , Troisi Roberto I. , Aldrighetti Luca , Bjorn Edwin , Abu Hilal Mohammed , Belli Giulio , Kaneko Hironori , Jarnagin William R. , Lin Charles , Pekolj Juan , Buell Joseph F. , Wakabayashi Go 
Published: August 2014

Abstract Although minor laparoscopic liver resections (LLRs) appear as standardized procedures, major LLRs are still limited to few expert teams. The aim of this study was to report the combined data of 18 international centers performing major LLR. Variables evaluated were number and type of LLR, surgical indications, number of synchronous colorectal resections, details on technical points, conversion rates, operative time, blood loss and surgical margins. From 1996 to 2014, a total of 5388 LLR were carried out including 1184 major LLRs. The most frequent indication for laparoscopic right hepatectomy (LRH) was colorectal liver metastases (37.0%). Seven centers used hand assistance or hybrid approach selectively for LRH mostly at the beginning of their experience. Seven centers apply Pringle's maneuver routinely. The conversion rate for all major LLRs was 10% and mean operative time was 291 min. Mean estimated blood loss for all major LLR was 327 ml and negative surgical margin rate was 96.5%. Major LLRs still remain challenging procedures requiring important experience in both laparoscopy and liver surgery. Stimulating the younger generation to learn and accomplish these techniques is the better way to guarantee further development of this surgical field.
Evaluation of atlas‐based auto‐segmentation software in prostate cancer patients
Authors: Greenham Stuart , Dean Jenna , Fu Cheuk Kuen Kenneth , Goman Joanne , Mulligan Jeremy , Tune Deanna , Sampson David , Westhuyzen Justin , McKay Michael 
Published: August 2014

AbstractIntroductionThe performance and limitations of an atlas‐based auto‐segmentation software package (ABAS; Elekta Inc.) was evaluated using male pelvic anatomy as the area of interest.MethodsContours from 10 prostate patients were selected to create atlases in ABAS. The contoured regions of interest were created manually to align with published guidelines and included the prostate, bladder, rectum, femoral heads and external patient contour. Twenty‐four clinically treated prostate patients were auto‐contoured using a randomised selection of two, four, six, eight or ten atlases. The concordance between the manually drawn and computer‐generated contours were evaluated statistically using Pearson's product–moment correlation coefficient (r) and clinically in a validated qualitative evaluation. In the latter evaluation, six radiation therapists classified the degree of agreement for each structure using seven clinically appropriate categories.ResultsThe ABAS software generated clinically acceptable contours for the bladder, rectum, femoral heads and external patient contour. For these structures, ABAS‐generated volumes were highly correlated with ‘as treated’ volumes, manually drawn; for four atlases, for example, bladder r = 0.988 (P < 0.001), rectum r = 0.739 (P < 0.001) and left femoral head r = 0.560 (P < 0.001). Poorest results were seen for the prostate (r = 0.401, P < 0.05) (four atlases); however this was attributed to the comparison prostate volume being contoured on magnetic resonance imaging (MRI) rather than computed tomography (CT) data. For all structures, increasing the number of atlases did not consistently improve accuracy.ConclusionsABAS‐generated contours are clinically useful for a range of structures in the male pelvis. Clinically appropriate volumes were created, but editing of some contours was inevitably required. The ideal number of atlases to improve generated automatic contours is yet to be determined.
Effect of ACL graft material on joint forces during a simulated in vivo motion in the porcine knee: Examining force during the initial cycles
Authors: Boguszewski Daniel V. , Wagner Christopher T. , Butler David L. , Shearn Jason T. 
Published: August 2014

ABSTRACTThis study compared three‐dimensional forces in knees containing anterior cruciate ligament (ACL) graft materials versus the native porcine ACL. A six‐degree‐of‐freedom (DOF) robot simulated gait while recording the joint forces and moments. Knees were subjected to 10 cycles of simulated gait in intact, ACL‐deficient, and ACL‐reconstructed knee states to examine time zero biomechanical performance. Reconstruction was performed using bone‐patellar tendon‐bone allograft (BPTB), reconstructive porcine tissue matrix (RTM), and an RTM‐polymer hybrid (Hybrid). Forces and moments were examined about anatomic DOFs throughout the gait cycle and at three key points during gait: heel strike (HS), mid stance (MS), toe off (TO). Compared to native ACL, each graft restored antero‐posterior (A‐P) forces throughout gait. However, all failed to mimic normal joint forces in other DOFs. For example, each reconstructed knee showed greater compressive forces at HS and TO compared to the native ACL knee. Overall, the Hybrid graft restored more of the native ACL forces following reconstruction than did BPTB, while RTM grafts were the least successful. If early onset osteoarthritis is in part caused by altered knee kinematics, then understanding how reconstruction materials restore critical force generation during gait is an essential step in improving a patient's long‐term prognosis. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:1458–1463, 2014.
Qualitative and Spatial Metabolite Profiling of Lichens by a LC–MS Approach Combined With Optimised Extraction
Authors: Parrot Delphine , Peresse Tiphaine , Hitti Eric , Carrie Daniel , Grube Martin , Tomasi Sophie 
Published: August 2014

IntroductionLichens are self‐sustaining partnerships comprising fungi as shape‐forming partners for their enclosed symbiotic algae. They produce a tremendous diversity of metabolites (1050 metabolites described so far).ObjectivesA comparison of metabolic profiles in nine lichen species belonging to three genera (Lichina, Collema and Roccella) by using an optimised extraction protocol, determination of the fragmentation pathway and the in situ localisation for major compounds in Roccella species.MethodsChemical analysis was performed using a complementary study combining a Taguchi experimental design with qualitative analysis by high‐performance liquid chromatography coupled with mass spectrometry techniques.ResultsOptimal conditions to obtain the best total extraction yield were determined as follows: mortar grinding to a fine powder, two successive extractions, solid:liquid ratio (2:60) and 700 rpm stirring. Qualitative analysis of the metabolite profiling of these nine species extracted with the optimised method was corroborated using MS and MS/MS approaches. Nine main compounds were identified: 1 β‐orcinol, 2 orsellinic acid, 3 putative choline sulphate, 4 roccellic acid, 5 montagnetol, 6 lecanoric acid, 7 erythrin, 8 lepraric acid and 9 acetylportentol, and several other compounds were reported. Identification was performed using the m/z ratio, fragmentation pathway and/or after isolation by NMR analysis. The variation of the metabolite profile in differently organised parts of two Roccella species suggests a specific role of major compounds in developmental stages of this symbiotic association.ConclusionMetabolic profiles represent specific chemical species and depend on the extraction conditions, the kind of the photobiont partner and the in situ localisation of major compounds. Copyright © 2014 John Wiley & Sons, Ltd.
Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine‐like nucleic acid analog COA‐Cl in cultured human vascular endothelial cells
Authors: Igarashi Junsuke , Hashimoto Takeshi , Kubota Yasuo , Shoji Kazuyo , Maruyama Tokumi , Sakakibara Norikazu , Takuwa Yoh , Ujihara Yoshihiro , Katanosaka Yuki , Mohri Satoshi , Naruse Keiji , Yamashita Tetsuo , Okamoto Ryuji , Hirano Katsuya , Kosaka Hiroaki , Takata Maki , Konishi Ryoji , Tsukamoto Ikuko 
Published: August 2014

AbstractCOA‐Cl (2Cl‐C.OXT‐A) is a recently developed adenosine‐like nucleic acid analog that promotes angiogenesis via the mitogen‐activated protein (MAP) kinases ERK1/2. Endothelial S1P1 receptor plays indispensable roles in developmental angiogenesis. In this study, we examined the functions of S1P1 in COA‐Cl‐induced angiogenic responses. Antagonists for S1P1, W146, and VPC23019, substantially but still partly inhibited the effects of COA‐Cl with regard to ERK1/2 activation and tube formation in cultured human umbilical vein endothelial cells (HUVEC). Antagonists for adenosine A1 receptor and purinergic P2Y1 receptor were without effect. Genetic knockdown of S1P1 with siRNA, but not that of S1P3, attenuated COA‐Cl‐elicited ERK1/2 responses. The signaling properties of COA‐Cl showed significant similarities to those of sphingosine 1‐phosphate, an endogenous S1P1 ligand, in that both induced responses sensitive to pertussis toxin (Gα i/o inhibitor), 1,2‐bis(2‐aminophenoxy)ethane‐N,N,N',N'‐tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA‐AM), (calcium chelator), and PP2 (c‐Src tyrosine kinase inhibitor). COA‐Cl elevated intracellular Ca2+ concentration and induced tyrosine phosphorylation of p130Cas, a substrate of c‐Src, in HUVEC. COA‐Cl displaced [3H]S1P in a radioligand‐binding competition assay in chem‐1 cells overexpressing S1P1. However, COA‐Cl activated ERK1/2 in CHO‐K1 cells that lack functional S1P1 receptor, suggesting the presence of additional yet‐to‐be‐defined COA‐Cl target in these cells. The results thus suggest the major contribution of S1P1 in the angiogenic effects of COA‐Cl. However, other mechanism such as that seen in CHO‐K1 cells may also be partly involved. Collectively, these findings may lead to refinement of the design of this nucleic acid analog and ultimately to development of small molecule‐based therapeutic angiogenesis.
Cardiovascular and Affective Consequences of Ruminating on a Performance Stressor Depend on Mode of Thought
Authors: Zoccola Peggy M. , Rabideau Erin M. , Figueroa Wilson S. , Woody Alex 
Published: August 2014

AbstractPsychological detachment from work is important for facilitating recovery. This can be threatened by rumination, or thinking about the day's stressors. Rumination may lead to distress, fatigue and extended activation of stress‐related systems, but findings are not unequivocal. Level of construal (abstract or concrete) and type of mentation (imagery or verbal thought) used during stressor‐focused rumination may shape physiological and affective responses and impact recovery. This study tested whether blood pressure (BP) and anxiety responses to stressor‐focused rumination differ by mentation type and construal level. Healthy undergraduates (n = 136) performed a speech stressor and then completed a rumination task in one of four randomly assigned conditions: concrete imagery, abstract imagery, concrete verbal thought or abstract verbal thought. Anxiety and continuous BP were assessed. Concrete rumination led to greater BP, whereas rumination with abstract construals led to lower BP. Furthermore, participants in the abstract conditions had greater increases in anxiety following stressor‐focused rumination than in the concrete conditions. Results suggest that the immediate physiological and psychological consequences of stressor‐focused rumination depend upon mode of thought. Copyright © 2014 John Wiley & Sons, Ltd.
Do feelings matter? On the correlation of affects and the self‐assessed productivity in software engineering
Authors: Graziotin Daniel , Wang Xiaofeng , Abrahamsson Pekka 
Published: August 2014

AbstractSoftware engineering (SE) research lacks theory and methodologies for addressing human aspects in software development. Development tasks are undertaken through cognitive processing activities. Affects (emotions, moods, and feelings) have a linkage to cognitive processing activities and the productivity of individuals. SE research needs to incorporate affect measurements to valorize human factors and to enhance management styles.The objective of this study is to analyze the affects dimensions of valence, arousal, and dominance of software developers and their real‐time correlation with their self‐assessed productivity (sPR).A repeated measurements design was conducted with eight participants (four students and four professionals), conveniently sampled and studied individually over 90 min of programming. The analysis was performed by fitting a linear mixed‐effects (LME) model.The results showed that valence and dominance are positively correlated with the sPR. The model was able to express about 38% of deviance from the sPR. Many lessons were learned when employing psychological measurements in SE and for fitting LME.This article demonstrates the value of applying psychological tests in SE and echoes a call to valorize the human individualized aspects of software developers. It reports a body of knowledge about affects, their classification, their measurement, and the best practices to perform psychological measurements in SE with LME models. Copyright © 2014 John Wiley & Sons, Ltd.
A 3D Porous Metal Organic Framework Based on Infinite 1D Nickel(II) Chains with Rutile Topology Displaying Open Metal Sites
Authors: Stylianou Kyriakos C. , Bacsa John , Bradshaw Darren , Rosseinsky Matthew J. 
Published: August 2014

AbstractThe reaction of NiII with a tetra‐benzoate pyrene ligand produces a 3D porous framework based on infinite 1D NiII chains. The NiII–O connectivity and the formation of a hydroxo‐bridge (μ3‐OH) responsible for the connection of the central NiII atoms within the 1D NiII–(μ3‐OH)2–NiII chains can be straightforwardly compared with the TiIV–O–TiIV connectivity seen in TiO2. The arrangement of the TBAPy ligand around the 1D rutile‐based chains leads in the generation of a porous framework with two distinct types of pores; based on the chemistries of these two types of pores, one can be labelled as hydrophobic and the other as hydrophilic. The use of different activation methods results in the generation of either a porous framework free of guest molecules or a completely solvent‐free material, in which the terminal H2O molecules bound to NiII were removed, leading thus to a framework with open NiII sites. CO2 isotherms collected on both frameworks at 195 K and one barshowed type I isotherms characteristic of microporous materials (BET surface areas for: guest‐free framework: 257(3) m2·g–1; solvent‐free framework: 362(2) m2·g–1). The affinity of both networks at zero coverage for both CO2 and CH4 was found to be greater when the unsaturated NiII sites are available within the void space.
The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control
Authors: He Jing-Yu , Ma Na , Zhu Shu , Komatsu Katsuko , Li Zhi-Yuan , Fu Wei-Ming 
Published: August 2014

Abstract

Codonopsis, in the family Campanulaceae, is a genus containing 42 species of dicotyledonous herbaceous perennial plants, predominantly found in Central, East and South Asia. Several Codonopsis species are widely used in traditional medicine and are considered to have multiple medicinal properties. Among the Codonopsis species, Codonopsis pilosula (Franch.) Nannf. and C. lanceolata (Sieb. et Zucc.) Benth. & Hook. f. ex Trautv. are more popular than others according to the findings, especially phytochemical and bioactive studies. Phytochemical research shows that Codonopsis species contain mainly polyacetylenes, phenylpropanoids, alkaloids, triterpenoids and polysaccharides, which contribute to multiple bioactivities. However, the mechanisms of their bioactivities need to be further elucidated. The less popular Codonopsis species remain to be studied and exploited. In addition, although a series of methods for the quality evaluation of Codonopsis species have been developed, a feasible and reliable approach to the efficacious and safe use of various Codonopsis species is still needed, with considering botanical origin, chemical constituents and bioactive effects. This review aims to provide up-to-date and comprehensive information on the phytochemistry, bioactivity and quality control of medicinal plants in the genus Codonopsis and to highlight current gaps in knowledge, which is useful for the wider development of the Codonopsis genus.
Testing Oleic‐SDS Mixture in the Absence/Presence Na2SO4 as a Phosphate Depressant
Authors: El‐Midany Ayman A. , Arafat Yasir , Al‐Fariss Tariq F. 
Published: August 2014

AbstractThe reverse flotation of calcareous phosphate ores, at acidic pH, usually uses anionic collectors such as oleic acid (Ol) and sodium dodecyl sulfate (SDS). However, using a mixture of two anionic collectors is very rare. In the present paper, a mixture of oleic acid and sodium dodecyl sulfate, with a ratio 1:1, was prepared. Different dosages of Ol–SDS mixture was studied in absence or presence of sodium sulfate as a phosphate depressant at different pH values. The results showed that sodium sulfate works better at highly acidic pH where 30.7 % P2O5 was achieved in presence of sodium sulfate in comparison to 29 % P2O5 at pH 4 and 0.5 kg/t collector dosage. However, by increasing the pH, the sodium sulfate negatively affects the concentrate grade. Moreover, the sodium sulfate maintains the grade and recovery almost unchanged within the studied pH range. Although a concentrate grade exceeds 30 % P2O5 could be achieved with or without addition of sodium sulfate, the highest concentrate grade of 33 % P2O5 was obtained with 85 % recovery at 3.5 kg/t collector dosage and pH 6 with no sodium sulfate additions.
Impact of climate change on weeds in agriculture: a review
Authors: Peters Kristian , Breitsameter Laura , Gerowitt Bärbel 
Published: August 2014

AbstractOver the past decades, climate change has induced transformations in the weed flora of arable ecosystems in Europe. For instance, thermophile weeds, late-emerging weeds, and some opportunistic weeds have become more abundant in some cropping systems. The composition of arable weed species is indeed ruled by environmental conditions such as temperature and precipitation. Climate change also influences weeds indirectly by enforcing adaptations of agronomic practice. We therefore need more accurate estimations of the damage potential of arable weeds to develop effective weed control strategies while maintaining crop yield. Here we review the mechanisms of responses of arable weeds to the direct and indirect effects of climate change. Climate change effects are categorized into three distinct types of shifts occurring at different scales: (1) range shifts at the landscape scale, (2) niche shifts at the community scale, and (3) trait shifts of individual species at the population scale. Our main conclusions are changes in the species composition and new species introductions are favored, which facilitate major ecological and agronomical implications. Current research mainly considers processes at the landscape scale. Processes at the population and community scales have prevalent importance to devise sustainable management strategies. Trait-climate and niche-climate relationships warrant closer consideration when modeling the possible future distribution and damage potential of weeds with climate change.
Personal growth initiative and identity formation in adolescence through young adulthood: Mediating processes on the pathway to well‐being
Authors: Luyckx Koen , Robitschek Christine 
Published: August 2014

ABSTRACTDeveloping a personal identity is a challenging task throughout adolescence and the transition to adulthood. The present study sampling 551 14–35 year olds (54.1% female) examined personal growth initiative (PGI) as a potential predictor of core identity processes and explored whether identity functioned as a mediator on the pathway from PGI to self‐esteem and depressive symptoms. Path analyses from a structural equation modeling approach indicated that all four components of PGI (i.e., planfulness, readiness for change, intentional behavior, and using resources) predicted different commitment and exploration processes, with planfulness being the most consistent predictor. Important age differences linking PGI‐components to identity exploration were found. Finally, especially the degree to which individuals identified themselves with their identity commitments and the degree to which they relied on ruminative or maladaptive forms of identity exploration mediated pathways from PGI to self‐esteem and depressive symptoms. Implications and suggestions for future research are discussed.
Remembering Lenny Bruce
Authors: Marowitz Charles 
Published: August 2014

On 13 October 2012, Lenny Bruce, had he not accidentally overdosed on narcotics (or committed suicide – the jury is still out on that one), would be eighty-seven years old. It is, of course, a thoroughly incredible notion – like an octogenarian Mozart, a super annuated Janis Joplin, or James Dean signing up for a senior citizen pension. Poètes maudits, doomed rock icons, and self-destructive superstars are supposed to die young. Their myth demands it, and we wouldn't have it any other way.Bruce at forty-one, perched on a toilet bowl with a spike in his right arm and his last typed words (‘conspiracy to interfere with the Fourth Amendment const—’) in the barrel of his still humming electric typewriter, died characteristically. He was always associated with toilet humour and throughout the last decade of his life ex hausted himself trying to demonstrate that the United States Constitution protected the free speech for which one court after another mercilessly prosecuted him. (The Fourth Amendment, incidentally, protects citizens from ‘unreasonable searches and seizures’ and, along with the state's First Amendment violations, was as much responsible for his downfall as the cocaine and morphine.)
Optogenetic approaches to retinal prosthesis
Authors: BARRETT JOHN MARTIN , BERLINGUER-PALMINI ROLANDO , DEGENAAR PATRICK 
Published: August 2014

AbstractThe concept of visual restoration via retinal prosthesis arguably started in 1992 with the discovery that some of the retinal cells were still intact in those with the retinitis pigmentosa disease. Two decades later, the first commercially available devices have the capability to allow users to identify basic shapes. Such devices are still very far from returning vision beyond the legal blindness. Thus, there is considerable continued development of electrode materials, and structures and electronic control mechanisms to increase both resolution and contrast. In parallel, the field of optogenetics—the genetic photosensitization of neural tissue holds particular promise for new approaches. Given that the eye is transparent, photosensitizing remaining neural layers of the eye and illuminating from the outside could prove to be less invasive, cheaper, and more effective than present approaches. As we move toward human trials in the coming years, this review explores the core technological and biological challenges related to the gene therapy and the high radiance optical stimulation requirement.