bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium‐Catalyzed Aryl CH Activation and Tandem ortho‐Hydroxylation/Alkoxylation of 2‐Aryl Benzimidazoles: Cytotoxicity and DNA‐Binding Studies
Authors: Kamal Ahmed , Srinivasulu Vunnam , Sathish Manda , Tangella Yellaiah , Nayak V. Lakshma , Rao M. P. Narasimha , Shankaraiah Nagula , Nagesh Narayana 
Published: December 2013

AbstractAn efficient regio‐selective aryl CH activation and tandem o‐hydroxylation method for 2‐arylbenzimidazoles has been developed by using a Pd(OAc)2/oxone/Cs2CO3 catalytic system. This reaction was successfully optimized by using various catalysts, oxidants, bases, and solvents to achieve the desired products in good yields. Further, preliminary mechanistic studies were conducted to examine the source of oxygen for this transformation. Gratifyingly, this catalytic system is also suitable for the introduction of various alkoxy groups, and delivered the products in good yields. The synthesized compounds were evaluated for their cytotoxic activity in selected human cancer cell lines. Some of the representative compounds (1 f, 2 f, 3 f and 4 f) have significant IC50 values ranging from 1–10 μM. Structure‐activity relationship studies indicate that in these compounds the ethoxy substituent is probably responsible for the improved activity. In addition, the DNA‐binding potential of these compounds was also investigated by UV/vis, fluorescence, and circular dichroism spectroscopy.
Constructing Hybrid Protein Zymogens through Protective Dendritic Assembly
Authors: Ng David Y. W. , Arzt Matthias , Wu Yuzhou , Kuan Seah Ling , Lamla Markus , Weil Tanja 
Published: December 2013

AbstractThe modulation of protein uptake and activity in response to physiological changes forms an integral part of smart protein therapeutics. We describe herein the self‐assembly of a pH‐responsive dendrimer shell onto the surface of active enzymes (trypsin, papain, DNase I) as a supramolecular protecting group to form a hybrid dendrimer–enzyme complex. The attachment is based on the interaction between boronic acid and salicyl hydroxamate, thus allowing the macromolecular assembly to respond to changes in pH between 5.0 and 7.4 in a highly reversible fashion. Catalytic activity is efficiently blocked in the presence of the dendrimer shell but is quantitatively restored upon shell degradation under acidic conditions. Unlike the native proteases, the hybrid constructs are shown to be efficiently taken up by A549 cells and colocalized in the acidic compartments. The programmed intracellular release of the proteases induced cytotoxicity, thereby uncovering a new avenue for precision biotherapeutics.
On Near‐controllability of Discrete‐time Upper‐triangular Bilinear Systems with Applications to Controllability
Authors: Tie Lin 
Published: December 2013

AbstractNear‐controllability is defined for those systems that are uncontrollable but have a large controllable region. It is a property of nonlinear control systems introduced recently, and it has been demonstrated on two classes of discrete‐time bilinear systems. This paper studies near‐controllability of discrete‐time upper‐triangular bilinear systems, which are uncontrollable and are more general than the two classes mentioned. A necessary and sufficient condition for the systems in dimension two to be nearly controllable is presented, which covers the existing results. For the systems with high dimensions, necessary conditions and sufficient conditions of near‐controllability are provided, which generalize the existing results. In particular, the obtained near‐controllability results are applied to controllability of discrete‐time bilinear systems. An example also is given to demonstrate the effectiveness, which shows that the controllability problems of discrete‐time bilinear systems can be solved by near‐controllability.
Robust Tracking Control of Helicopters Using Backstepping with Disturbance Observers
Authors: He Yuebang , Pei Hailong , Sun Tairen 
Published: December 2013

AbstractThis paper addresses the robust and accurate trajectory tracking problem for unmanned helicopters in the presence of model uncertainties and external disturbances. First, the helicopter's model is simplified to a six‐degrees‐of‐freedom rigid body augmented with a simplified rotor dynamic model, with the model uncertainties and the external disturbances being treated as lumped unknown disturbances. Second, a nonlinear disturbance observer is designed to estimate this lumped disturbance. Then, a backstepping controller with disturbance compensation is designed to ensure robust and highly trajectory tracking. After that, the theoretical analysis of the efficiency of the designed disturbance observer‐based backstepping controller (Backstepping+DO) is shown by the Lyapunov theory. Finally, simulation results and conclusions are presented and discussed.
Circadian rhythms and mood: Opportunities for multi‐level analyses in genomics and neuroscience
Authors: Li Jun Z. 
Published: December 2013

In the healthy state, both circadian rhythm and mood are stable against perturbations, yet they are capable of adjusting to altered internal cues or ongoing changes in external conditions. The dual demands of stability and flexibility are met by the collective properties of complex neural networks. Disruption of this balance underlies both circadian rhythm abnormality and mood disorders. However, we do not fully understand the network properties that govern the crosstalk between the circadian system and mood regulation. This puzzle reflects a challenge at the center of neurobiology, and its solution requires the successful integration of existing data across all levels of neural organization, from molecules, cells, circuits, network dynamics, to integrated mental function. This essay discusses several open questions confronting the cross‐level synthesis, and proposes that circadian regulation, and its role in mood, stands as a uniquely tractable system to study the causal mechanisms of neural adaptation.Also watch the Video Abstract.Editor's suggested further reading in BioEssays Major depressive disorder: A loss of circadian synchrony? Abstract.
A colorimetric and ratiometric fluorescent probe for sulfite based on an intramolecular cleavage mechanism
Authors: Hou Peng , Chen Song , Voitchovsky Kislon , Song Xiangzhi 
Published: December 2013

ABSTRACTA colorimetric and ratiometric fluorescent sulfite probe, the levulinate of 4‐hydroxynaphthalimide, was successfully synthesized from 4‐hydroxy‐naphthalimide and levulinic acid. Through sulfite‐mediated intramolecular cleavage, the probe was converted into 4‐hydroxynaphthalimide, which when excited at 450 nm, displayed a large Stokes shift due to the intramolecular charge transfer process. The probe exhibited high selectivity and sensitivity towards sulfite over other typical anionic species (F–, Cl–, Br–, I–, HPO42–, SO42–, NO3–, AcO–, ClO4–, HCO3–) in HEPES‐buffered solution (25 mm, pH 7.4, 50% acetonitrile, v/v). Copyright © 2013 John Wiley & Sons, Ltd.
Protein Engineering of the Antitumor Enzyme PpADI for Improved Thermal Resistance
Authors: Zhu Leilei , Cheng Feng , Piatkowski Victoria , Schwaneberg Ulrich 
Published: December 2013

AbstractArginine deiminase (ADI, EC 3.5.3.6) is a potential antitumor drug for the treatment of arginine‐auxotrophic tumors such as hepatocellular carcinomas (HCCs) and melanomas. Studies in human lymphatic leukemia cell lines have confirmed the anti‐angiogenic activity of ADI. Activity and thermal resistance limit the efficacy of ADI in treatment of auxotrophic tumors. Previously, we reengineered ADI fromPseudomonas plecoglossicida(PpADI) for improved activity under physiological conditions (37 °C, PBS buffer, pH 7.4) by two rounds of directed evolution and combination of beneficial substitutions through site‐directed mutagenesis. The best variant, PpADI M6 (K5T/D38H/D44E/A128T/E296K/H404R), showed a 64.7‐fold improvement inkcatvalue and a 37.6 % decreasedS0.5value under physiological conditions. However, M6 lost rapidly its activity (half‐life of ∼2 days at 37 °C). Here we report the re‐engineering of PpADI M6 for improved thermal resistance by directed evolution in order to increase its half‐life under physiological conditions. Directed evolution and recombination of the two most beneficial positions yielded variant PpADI M9 (K5T/D38H/D44E/A128T/V140L/E296K/F325L/H404R), for which theTmvalue increased from 47 (M6) to 54 °C (M9); this corresponds to an increased half‐life from ∼2 days (M6) to ∼3.5 days (M9) under physiological conditions. Structure analysis of the homology model of M9 showed that the beneficial substitutions V140L and F325L likely promote the formation of tetrameric PpADI, which has greater thermal resistance than dimeric PpADI.
Influence of Ph2PN(R)P(Ph)N(R)H (R=c‐Hex, iPr) Ligand Substituents, Modifier, and Process Parameters on Reaction Kinetics of a Chromium‐based Catalyst for the Selective Trimerization of Ethylene
Authors: Heinig Stefan , Wöhl Anina , Müller Wolfgang , Al‐Hazmi Mohammed H. , Müller Bernd H. , Peulecke Normen , Rosenthal Uwe 
Published: December 2013

AbstractThe influence of ligand substituents on a homogeneous, highly selective catalyst system for the ethylene trimerization to 1‐hexene, consisting of chromium(III)acetylacetonate as a chromium source, tetraphenylphosphonium chloride ([Ph4P]Cl) or dodecyltrimethylammonium chloride ([CH3(CH2)11N(CH3)3]Cl) as a modifier and chlorine source, Ph2PN(iPr)P(Ph)N(iPr)H (L0) as a ligand (Ph=phenyl, iPr=isopropyl), and triethylaluminum as an activator, was investigated. It was shown that the phosphonium or ammonium salts act as both chlorine source and as modifier for the activator triethylaluminum. Additionally, a systematic parameter study using Ph2PN(c‐Hex)P(Ph)N(c‐Hex)H (L1) as the ligand (c‐Hex=cyclohexyl) was performed and important performance figures for catalyst systems using L0 and L1 ligands, respectively, were compared under different reaction conditions. As a result, both catalyst systems demonstrate very similar kinetics at identical ethylene pressures, temperatures, and ligand concentrations. Additionally, the influence of the modifiers on the performance of the catalyst systems at different ethylene pressures and temperatures was studied in detail. The results suggest that the modifier has a greater influence on the reaction mechanism than expected. Moreover, the influence of the modifier on the catalytic performance was found to be more significant than the impact of the ligand’s chemical nature.
Highly Active Small Palladium Clusters Supported on Ferric Hydroxide for Carbon Monoxide‐Tolerant Hydrogen Oxidation
Authors: Qiao Botao , Lin Jian , Li Lin , Wang Aiqin , Liu Jingyue , Zhang Tao 
Published: December 2013

AbstractProton‐exchange membrane fuel cells have been regarded as one of the most promising candidates for efficient energy conversion. However, the CO poisoning of the anode and the scarcity of the Pt metal are two major barriers to their commercialization. Development of CO‐tolerant Pd electrocatalysts is considered to be a plausible approach to overcome these problems. Herein we report that for the CO‐tolerant H2 oxidation, sub‐2‐nm size Pd clusters as well as single atoms, supported on FeOx nanocrystallites, are highly active and durable at a wide temperature range of 20–120 °C. Experimental data demonstrated that CO preferentially adsorbs on these small Pd clusters or single atoms linearly, resulting in weakened CO binding and enhanced H2 competitive adsorption. Therefore, FeOx‐supported small Pd clusters or single atoms provide a higher CO‐tolerant performance. This finding may offer a new strategy to develop CO‐tolerant Pd‐based electrodes.
Efficient Copper‐Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen‐Based Nucleophiles
Authors: Lin Jin‐Shun , Xiong Ya‐Ping , Ma Can‐Liang , Zhao Li‐Jiao , Tan Bin , Liu Xin‐Yuan 
Published: December 2013

AbstractA mild, convenient, and step‐economical intramolecular aminotrifluoromethylation of unactivated alkenes with a variety of electronically distinct, nitrogen‐based nucleophiles in the presence of a simple copper salt catalyst, in the absence of extra ligands, is described. Many different nitrogen‐based nucleophiles (e.g., basic primary aliphatic and aromatic amines, sulfonamides, carbamates, and ureas) can be employed in this new aminotrifluoromethylation reaction. The aminotrifluoromethylation process allows straightforward access to diversely substituted CF3‐containing pyrrolidines or indolines, in good to excellent yields, through a direct difunctionalization strategy from the respective acyclic starting materials. Mechanistic studies were conducted and a plausible mechanism was proposed.
Dispersible Carbon Nanotubes
Authors: Soulié‐Ziakovic Corinne , Nicolaÿ Renaud , Prevoteau Alexandre , Leibler Ludwik 
Published: December 2013

AbstractA method is proposed to produce nanoparticles dispersible and recyclable in any class of solvents, and the concept is illustrated with the carbon nanotubes. Classically, dispersions of CNTs can be achieved through steric stabilization induced by adsorbed or grafted polymer chains. Yet, the surface modification of CNTs surfaces is irreversible, and the chemical nature of the polymer chains imposes the range of solvents in which CNTs can be dispersed. To address this limitation, supramolecular bonds can be used to attach and to detach polymer chains from the surface of CNTs. The reversibility of supramolecular bonds offers an easy way to recycle CNTs as well as the possibility to disperse the same functional CNTs in any type of solvent, by simply adapting the chemical nature of the stabilizing chains to the dispersing medium. The concept of supramolecular functionalization can be applied to other particles, for example, silica or metal oxides, as well as to dispersing in polymer melts, films or coatings.
ChemInform Abstract: Magnesium Double Nitride Mg3GaN3 as New Host Lattice for Eu2+ Doping: Synthesis, Structural Studies, Luminescence, and Band‐Gap Determination.
Authors: Hintze Frauke , Johnson Neil W. , Seibald Markus , Muir David , Moewes Alexander , Schnick Wolfgang 
Published: December 2013

AbstractEu‐doped Mg3GaN3 (I) and binary nitride Mg3N2 (II) are prepared by reaction of the corresponding metals with NaN3 in a sodium flux (welded Ta ampules, 760 °C, 2 d; cooling to 200 °C with a rate of 0.06 °C/min).
ChemInform Abstract: Noncentrosymmetric Cubic CsCdBO3 with Bichromophore.
Authors: Yu Hongwei , Wu Hongping , Pan Shilie , Zhang Bingbing , Wen Ming , Yang Zhihua , Li Hongyi , Jiang Xiangzhan 
Published: December 2013

AbstractSingle crystals of the title compound are obtained from a molten mixture of Cs2CO3, CdO, and H3BO3 (1:1:2 molar ratio, Pt crucible, 800 °C, 10 h).
ChemInform Abstract: Solid State Complex Chemistry: Formation, Structure, and Properties of Homoleptic Tetracyanamidogermanates RbRE[Ge(CN2)4] (RE: La, Pr, Nd, Gd).
Authors: Kalmutzki Markus , Enseling David , Wren John E. C. , Kroeker Scott , Terskikh Victor V. , Juestel Thomas , Meyer H.‐Juergen 
Published: December 2013

AbstractRbLn[Ge(CN2)4] (I) (Ln: La, Pr, Nd, Gd) and RbLn[Si(CN2)4] (II) are prepared by solid state metathesis reaction of stoichiometric mixtures of LnCl3, Rb2[GeF6] or Rb2[SiF6], and Li2(CN2) (evacuated silica ampoule, for (I): 450 °C, 1 d; for (II): 550 °C, 2 d).
ChemInform Abstract: A Novel POM‐Based Inorganic Porous Framework: Synthesis, Structure and Properties.
Authors: Sun Yingying , Lu Jing , Li Dacheng , Dou Jianmin 
Published: December 2013

Abstract(H2en)[Mn3P4Mo4O28] is hydrothermally synthesized from a mixture of (NH4)6Mo7O24, Mn(OAc)2, Dy(OAc)3, en, H3PO4, and H2O (pH 5, autoclave, 180 °C, 5 d; 75% yield).
ChemInform Abstract: A Survey of Sulfide Ligands for Allylic C—H Oxidations of Terminal Olefins.
Authors: Le Chi , Kunchithapatham Kamala , Henderson William H. , Check Christopher T. , Stambuli James P. 
Published: December 2013

AbstractScreening a 37‐membered library of thioether ligands has shown that tetrahydrothiophene is a highly reactive and selective ligand for Pd‐catalyzed allylic C—H oxidation reactions.
ChemInform Abstract: Catalyst‐Controlled Divergent C—H Functionalization of Unsymmetrical 2‐Aryl Cyclic 1,3‐Dicarbonyl Compounds with Alkynes and Alkenes.
Authors: Dooley Johnathon D. , Chidipudi Suresh Reddy , Lam Hon Wai 
Published: December 2013

AbstractThe oxidative annulation of alkynes and alkenes with unsymmetrical 2‐aryl cyclic 1,3‐dicarbonyl compounds is achieved with high site selectivity using palladium or ruthenium catalysis.
ChemInform Abstract: Type III‐B Rotaxane Dendrimers.
Authors: Ho Watson K.‐W. , Lee Siu‐Fung , Wong Chi‐Hin , Zhu Xiao‐Ming , Kwan Chak‐Shing , Chak Chun‐Pong , Mendes Paula M. , Cheng Christopher H. K. , Leung Ken Cham‐Fai 
Published: December 2013

AbstractNovel type III‐B dendrimers are synthesized via a modified copper‐catalyzed alkyne—azide cycloaddition, a Glaser—Hay′s acetylenic oxidative homocoupling, and an amide formation.
ChemInform Abstract: Enantioselective Synthesis of anti‐β‐Amido‐α‐hydroxy Esters via Asymmetric Transfer Hydrogenation Coupled with Dynamic Kinetic Resolution.
Authors: Villacrez Marvin , Somfai Peter 
Published: December 2013

AbstractA rapid and straightforward diastereo‐ and enantioselective synthesis of anti‐β‐amido‐α‐hydroxy esters (II) is achieved with the aid of a simply prepared chiral ruthenium catalyst.
ChemInform Abstract: K3PO4—KOH Mixture as Efficient Reagent for the Deprotection of 4‐Aryl‐2‐methyl‐3‐butyn‐2‐ols to Terminal Acetylenes.
Authors: Smeyanov Alexey , Schmidt Andreas 
Published: December 2013

AbstractAn efficient and fast method for the synthesis of terminal acetylenes (II) (18 examples) by deprotection of the title butynols (I) is developed.
ChemInform Abstract: Enantioselective Alkylation of Aldehydes Using Functionalized Alkylboron Reagents Catalyzed by a Chiral Titanium Complex.
Authors: Kumar Ravindra , Kawasaki Hiroki , Harada Toshiro 
Published: December 2013

AbstractAn octahydro‐BINOL derived titanium complex is used to catalyze the addition reaction of alkylboron reagents, generated in situ from terminal olefin precursors by hydroboration, to aldehydes to provide secondary alcohols with high enantioselectivities.
ChemInform Abstract: Microwave‐Assisted Convenient Synthesis of α,β‐Unsaturated Esters and Ketones via Aldol‐Adduct Elimination.
Authors: Suman Pathi , Rao Rayala Nageswara , Raju Bhimapaka China 
Published: December 2013

AbstractVarious fluorinated 3‐oxo ester and 1,3‐diketones are reacted with aldehydes (I) in the presence of piperidine to afford title compounds such as (III) and (V) (34 example).
ChemInform Abstract: Transformation of N‐Alkylated Anilines to N‐Aryloxamates.
Authors: Zhu Xiao‐He , Zhang Xin , Xin Hong‐Xing , Yan Hong 
Published: December 2013

AbstractA novel approach to title compounds (III) using 2‐diazoacetoacetate (II) as alkylating agent and a Rh‐complex as a catalyst is reported.
ChemInform Abstract: Construction of Vicinal Tertiary and All‐Carbon Quaternary Stereocenters via Ir‐Catalyzed Regio‐, Diastereo‐, and Enantioselective Allylic Alkylation and Applications in Sequential Pd Catalysis.
Authors: Liu Wen‐Bo , Reeves Corey M. , Virgil Scott C. , Stoltz Brian M. 
Published: December 2013

AbstractA highly regio‐, diastereo‐, and enantioselective Ir‐catalyzed α‐allylic alkylation of cyclic β‐ketoesters is presented.
ChemInform Abstract: Direct Oxidative Conversion of Methylarenes into Aromatic Nitriles.
Authors: Tsuchiya Daisuke , Kawagoe Yuhsuke , Moriyama Katsuhiko , Togo Hideo 
Published: December 2013

AbstractTwo cyanide‐free and transition‐metal‐free one‐pot procedures are presented for the synthesis of aromatic nitriles from methylarenes using NBS or 1,3‐dibromo‐5,5‐dimethylhydantoin as the oxidant.
ChemInform Abstract: Selective Oxidation of Alcohols to Esters Using Heterogeneous Co3O4—N@C Catalysts under Mild Conditions.
Authors: Jagadeesh Rajenahally V. , Junge Henrik , Pohl Marga‐Martina , Radnik Joerg , Brueckner Angelika , Beller Matthias 
Published: December 2013

AbstractCo3O4 supported on carbon‐nitrogen material represents an excellent catalyst for the selective oxidation of alcohols to esters using benign oxygen as the final oxidant.
ChemInform Abstract: Asymmetric Epoxidation of Alkenes Catalyzed by a Porphyrin‐Inspired Manganese Complex.
Authors: Dai Wen , Li Jun , Li Guosong , Yang Hua , Wang Lianyue , Gao Shuang 
Published: December 2013

AbstractIt is demonstrated that an optically active bisoxazoline ligand in combination with Mn(OTf)2 efficiently catalyzes the oxidation of various olefins with hydrogen peroxide to give epoxides with excellent enantioselectivities.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Annulation of Benzofuran‐2,3‐diones and Enals: A Concise Synthesis of Spiro‐bis‐lactone.
Authors: Wang Ze‐Dong , Wang Feng , Li Xin , Cheng Jin‐Pei 
Published: December 2013

AbstractThe regioselectivity of the formation of spiro‐bis‐lactones from benzofuran‐2,3‐diones and α,β‐unsaturated β‐aryl‐substituted aldehydes is investigated with different N‐heterocyclic carbene catalysts.
ChemInform Abstract: Platinum‐Catalyzed Tandem Indole Annulation/Arylation for the Synthesis of Diindolylmethanes and Indolo[3,2‐b]carbazoles.
Authors: Shu Dongxu , Winston‐McPherson Gabrielle N. , Song Wangze , Tang Weiping 
Published: December 2013

AbstractThe scope of different indoles and propargylic ethers is examined for the tandem annulation/arylation cascade reaction.
ChemInform Abstract: Development of a Tailor‐Made Bis(oxazolidine)pyridine—Metal Catalyst for the [3 + 2] Cycloaddition of Azomethine Imines with Propiolates.
Authors: Arai Takayoshi , Ogino Yuta , Sato Toru 
Published: December 2013

AbstractA series of bis(oxazolidine)pyridine ligands is designed and applied in the title reaction.
ChemInform Abstract: Starch—Sulfuric Acid (SSA) as Catalyst for a One‐Pot Synthesis of 1,5‐Diaryl‐1H‐pyrazoles.
Authors: Hatamjafari Farhad 
Published: December 2013

AbstractStarch‐supported sulfuric acid acts as an efficient and environmentally friendly catalyst for the regioselective synthesis of new pyrazoles (III) via condensation of Baylis—Hillman adducts (I) with phenylhydrazine.
ChemInform Abstract: Highly Regioselective Synthesis of 2,4,5‐(Hetero)aryl Substituted Oxazoles by Intermolecular [3 + 2] Cycloaddition of Unsymmetrical Internal Alkynes.
Authors: Chatzopoulou Elli , Davies Paul W. 
Published: December 2013

AbstractThe applied Au‐catalyst is prepared in one step.
ChemInform Abstract: Nitro‐Methyl Redox Coupling: Efficient Approach to 2‐Hetarylbenzothiazoles from 2‐Halonitroarene, Methylhetarene, and Elemental Sulfur.
Authors: Nguyen Thanh Binh , Ermolenko Ludmila , Al‐Mourabit Ali 
Published: December 2013

AbstractA simple, straightforward, and atom‐economic multicomponent synthesis of different substituted benzothiazoles from readily available starting materials is developed.
ChemInform Abstract: Bifunctional Building Blocks in the Ugi‐Azide Condensation Reaction: A General Strategy Toward Exploration of New Molecular Diversity.
Authors: Gunawan Steven , Hulme Christopher 
Published: December 2013

AbstractUgi‐azide reaction of tethered aldo/keto—acids/esters followed by a ring closing step opens access to a variety of complex lactam—tetrazoles.
ChemInform Abstract: An Efficient Synthesis of Novel 3‐Hydroxy‐12‐arylbenzo[a]xanthen‐11‐ones and 5,12‐Diarylxantheno[2,1‐a]xanthene‐4,12‐diones Using pTSA in [bmim]BF4.
Authors: Yadav Sneha , Nand Bhaskara , Khurana Jitender M. 
Published: December 2013

AbstractSimple, efficient and environmentally benign syntheses of novel xanthene derivatives via one‐pot multicomponent condensation reactions are developed.
ChemInform Abstract: Synthesis of Functionalized Isoquinolin‐1(2H)‐ones by Copper‐Catalyzed α‐Arylation of Ketones with 2‐Halobenzamides.
Authors: Shi Yan , Zhu Xuebin , Mao Haibin , Hu Hongwen , Zhu Chengjian , Cheng Yixiang 
Published: December 2013

AbstractA novel and efficient method for the synthesis of the title compounds through sequential α‐arylation and dehydrative cyclization processes is developed tolerating broad range of substituents.