bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study
Authors: Song Yongcai , Su Yujia , Hussain Shaik Althaf , Tang Cuiping 
Published: June 2024

Abstract
Rheumatoid arthritis is a chronic autoimmune-disease-causing inflammation, joint pain, and joint destruction, severely affecting the quality of life of millions worldwide. In the current research, a nanocarrier system was developed for the delivery of resveratrol and prednisolone to treat rheumatoid arthritis. The drug delivery system was characterized in vitro using scanning electron microscopy and various cell culture studies. Finally, the alleviative symptoms of the developed treatment strategy were investigated in a rat model of rheumatoid arthritis. In vitro studies showed that the carrier system released the drugs in a sustained manner and possessed strong immunomodulatory functions. Nanocarriers loaded with prednisolone, resveratrol, and drug-free carriers had 396.88 ± 76.41 nm, 392.49 ± 97.31 nm, and 338.02 ± 77.75 nm of mean particle size, respectively. In vivo studies revealed that local injection of the carrier system could alleviate the degenerative effects of rheumatoid arthritis. ELISA assays showed that the co-injection of resveratrol and prednisolone-loaded albumin nanoparticles could significantly modulate inflammatory responses. The developed treatment modality may potentially be used to treat rheumatoid arthritis.
GAMBARAN SEDENTARY LIFESTYLE PADA MAHASISWA PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA SELAMA MASA TRANSISI PANDEMI COVID-19
Authors: Santoso Ayu Meylianawati , Dinata I Made Krisna , Adiatmika I Putu Gede , Primayanti I Dewa Ayu Inten Dwi 
Published: June 2024

Sedentary lifestyle adalah perilaku yang terjadi pada saat kita duduk, berbaring, ataupun melakukan aktivitas yang membutuhkan energi sangat rendah. Sedentary lifestyle dapat dibedakan menjadi tiga tingkatan yaitu rendah, sedang, dan tinggi. Aktivitas fisik yang rendah pada mahasiswa Pendidikan Dokter Universitas Udayana menjadi salah satu faktor risiko dari Sedentary Lifestyle. Pembelajaran yang dilakukan dengan dua metode yaitu offline dan online menimbulkan perubahan pada aktivitas fisik mahasiswa. Penelitian ini bertujuan untuk mengetahui gambaran sedentary lifestyle pada mahasiswa Pendidikan Dokter Universitas Udayana selama masa transisi pandemi COVID-19. Penelitian ini merupakan penelitian deskriptif dengan metode cross-sectional. Penelitian ini dilakukan di Universitas Udayana dengan sampel mahasiswa Pendidikan Dokter angkatan 2019-2021. Besaran sampel yang diambil setelah menggunakan rumus Slovin adalah 98 sampel menggunakan simple random sampling. Terdapat 10 aktivitas sedentari yang didata durasi waktunya selama satu minggu. Bermain musik merupakan aktivitas sedentari yang jarang dilakukan mahasiswa Pendidikan Dokter dengan rata-rata dalam seminggu sebanyak 15 menit. Menggunakan handphone/mengobrol merupakan aktivitas sedentari yang sering dilakukan mahasiswa Pendidikan Dokter dengan rata-rata dalam seminggu sebanyak 4 jam. Sebanyak 95% mahasiswa Pendidikan Dokter Universitas Udayana dalam tingkat kegiatan sedentari yang tinggi. Sedentary Lifestyle pada mahasiswa Pendidikan Dokter beragam dengan kegiatan yang paling dominan adalah menggunakan handphone/mengobrol. Penelitian lebih lanjut perlu untuk menilai hubungan antar variabel dengan jumlah yang lebih besar dan desain kuisioner yang lebih menarik.
Kata kunci : Gambaran, Kegiatan Sedentari, Sedentary Lifestyle
Топография городского кладбища Маджара по архивным материалам XVIII–XIX вв. и археологическим источникам
Authors: Бабенко Виталий Александрович 
Published: June 2024

В статье анализируются сведения по топографии городского кладбища города Маджара, содержащиеся в архивных материалах XVIII–XIX вв. и в материалах археологических раскопок 1907, 1909, 1989-1991 и 2020 гг. Несмотря на то, что на протяжении XIX–XX вв. городищу Маджары был нанесен большой ущерб, планы Маджара, составленные А. Голохвостовым в 1742 г., И.А. Гильденштедтом и К. Гейслером во второй половине XVIII в., позволяют выделить на левобережной части городища городской некрополь. Они также позволяют определить ориентиры на местности для локализации отдельных участков некрополя. Важным источником информации являются сведения А.П. Архипова о последних четырех мавзолеях на городище и их локализации. Высказанные Э.В. Ртвеладзе, Е.И. Нарожным и И.Б. Тищенко предположения о наличии на городище нескольких мусульманских кладбищ, пока не получили подтверждение. Накопленные материалы позволяют определить примерные границы городского кладбища и выделить отдельный кочевнический могильник. Городское кладбище Маджара нуждается в новых исследованиях.
Epidemiological and Molecular Characterization of Malassezia species from Patients with pityriasis versicolor in Erbil Province
Authors: Hassan Zuber , Qurtas Dindar Sharif Qurtas 
Published: June 2024

Background: Pityriasis versicolor (PV) is the most common chronic superficial infection of the stratum corneum. Pityriasis versicolor is the prototypical skin disease etiologically connected to Malassezia species. Malassezia furfur is the primary causative agent of pityriasis versicolor which causes either hyperpigmentation or hypopigmentation of the skin.
Material and Methods: Sixty patients suffering from pityriasis versicolor disease who attended Erbil Dermatological Center, from August 2021 up to July 2023. Clinical diagnoses were done by consultant dermatologist. Thirty nine were males and Twenty-six were females. DNA has been extracted from skin scraps isolated from various body areas using the DNeasy Blood & Tissue Kit (Qiagen, Germany) and it was amplified using specific primers for Malassezia strains. The amplified PCR products were sequenced commercially in both directions (Macrogen Inc. South Korea).
Results: The largest proportion of infections was reported by hyperpigmentation (64.6%), followed by hypopigmentation (44.5%). The rosy-coloured lesions were present only in 8 (12.3%) of patients. Applying of polymerase chain reaction is extremely critical to verify the diagnosis of Malassezia species. Ribosomal region of sequence analysis revealed that, the sequences of 14 isolates under the accession number (MT000715 and MT000716) were (99.9%-100%) homologous to M. furfur under the accession number NG_057730 and 6 isolates under the accession number (MT000717) were (100%) homologous to M.globosa (AY743604 and AJ249951). Phylogenetic analyzes were performed to assist investigate the relationship of M.furfur and M.globosa to support these results in Erbil province.
Conclusions: Phylogenetic analysis of the fourteen isolates (M. furfur) under the accession (MT000715 and MT000716) and the remaining six isolates belonging to the M. globasa (MT000717) were analyzed by MEGA 5.05 and compared with sequences of different Malassezia species available in Gen Bank database, the data showed a clear convergence between our Malassezia isolates from Erbil patients and that of the Gen Bank database.
Adverse events and sedation characteristics of propofol and dexmedetomidine during magnetic resonance imaging: An observational study in neuropsychiatric population
Authors: Narayanan Shyamala , Kamath Sriganesh , Chakrabarti Dhritiman 
Published: June 2024

Objectives:
Propofol and dexmedetomidine are the most commonly used sedative drugs during magnetic resonance imaging (MRI) studies. However, data regarding peri-procedural adverse events, and the profile of these drugs concerning the quality of sedation, imaging, and recovery is limited in neurological and psychiatric populations. This study aimed to compare adverse events and sedation characteristics of propofol and dexmedetomidine during MRI studies in patients with neurological and psychiatric illnesses.

Materials and Methods:
This prospective observational study was conducted between March 2020 and September 2021 after the Ethics Committee’s approval and informed consent. Patients of all ages and genders undergoing elective MRI studies for neurological, neurosurgical, or psychiatric illness under sedation with either dexmedetomidine or propofol infusion were included in the study.

Results:
The patients in the dexmedetomidine group were older, had higher body mass index, and had more pre-procedure risk factors than the propofol group. Pre-medication use (midazolam or ketamine) was more in the propofol group. There was no difference in respiratory adverse events, but cardiovascular events (bradycardia and hypotension) were more with dexmedetomidine. There was no difference in the quality of sedation (patient movement, image quality, and need for repeating the imaging sequence). Recovery time from anesthesia was faster, and Aldrete score and Observer Assessment of Alertness/Sedation Scale scores in the post-anesthesia care unit were higher with propofol.

Conclusion:
Cardiovascular but not respiratory adverse events were more with dexmedetomidine, recovery profile was better with propofol, and both the drugs were similar regarding the quality of sedation and images in neurological and psychiatric patients undergoing MRI study.
Awake neurosurgery: Advancements in microvascular decompression for trigeminal neuralgia
Authors: Fareed Areeba , Iftikhar Zoha , Haider Ramsha , Shah Safa Irfan , Ennabe Michelle , Alan Albert , Weinand Martin 
Published: June 2024

Background:
The treatment landscape for trigeminal neuralgia (TN) involves various surgical interventions, among which microvascular decompression (MVD) stands out as highly effective. While MVD offers significant benefits, its success relies on precise surgical techniques and patient selection. In addition, the emergence of awake surgery techniques presents new opportunities to improve outcomes and minimize complications associated with MVD for TN.

Methods:
A thorough review of the literature was conducted to explore the effectiveness and challenges of MVD for TN, as well as the impact of awake surgery on its outcomes. PubMed and Medline databases were searched from inception to March 2024 using specific keywords “Awake Neurosurgery,” “Microvascular Decompression,” AND “Trigeminal Neuralgia.” Studies reporting original research on human subjects or preclinical investigations were included in the study.

Results:
This review highlighted that MVD emerges as a highly effective treatment for TN, offering long-term pain relief with relatively low rates of recurrence and complications. Awake surgery techniques, including awake craniotomy, have revolutionized the approach to MVD, providing benefits such as reduced postoperative monitoring, shorter hospital stays, and improved neurological outcomes. Furthermore, awake MVD procedures offer opportunities for precise mapping and preservation of critical brain functions, enhancing surgical precision and patient outcomes.

Conclusion:
The integration of awake surgery techniques, particularly awake MVD, represents a significant advancement in the treatment of TN. Future research should focus on refining awake surgery techniques and exploring new approaches to optimize outcomes in MVD for TN.
Thoroughbred or mongrel?
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Authors: Тариченко А. , Козликин А. , Жуков Р. , Скрипин П. 
Published: June 2024

Свиноматок породы крупная белая целесообразно скрещивать с хряками породы ландрас, поскольку помесный молодняк характеризуется лучшими откормочными качествами и превосходит чистопородных сверстников по интенсивности роста и по продуктивности.
It is practicable to cross Large White sows with Landrace boars as hybrid young animals are characterized by better fattening qualities and surpass thoroughbred herdmates in growth intensity and productivity.
Work-Related Alcohol Consumption: An Analysis of Motivators and Responses across Cultures
Authors: Gulev Rune Ellemose , Dukaric Gabriel 
Published: June 2024

While research into alcohol abuse is abundant, the science of how differing cultures view and respond to mild work-related alcohol consumption has been scientifically neglected. This article displays results from surveys conducted over a 7-year period and pivots around the cultural dimensions ‘Power distance’, ‘Individualism’, Indulgence’ and ‘Interpersonal trust’ which are correlated with motivators, responses and acceptance levels of mild work-related alcohol consumption. The strongest motivator for participating in mild work-related drinking was ‘To celebrate with colleagues’, which achieved significance with all cultural dimensions except power distance, which in contrast, achieved significance with the motivator ‘To bring out the real character’ of the counterpart. Power distance also correlated strongly with negative emotions regarding the refusal of a drink when offered by a senior. Altogether, 52 correlation tests were conducted of which 18 achieved significance. We believe that a better understanding of this topic will increase the likelihood of obtaining a harmonious workplace that lessens employee misunderstandings and conflict.
INVESTIGATING THE ASSOCIATION BETWEE AVERAGE HOTEL PRICES AND INTERNATIONAL TOURISM
Authors: Dutta Anupam 
Published: June 2024

Objective: The present study intends to examine the long- and short-run associations between average hotel prices and the international tourism demand in Singapore.

Theoretical Framework: Employing Johansen Cointegration method and linear ARDL bound tests, we fail to capture the long-term linkage between average hotel prices and the number of visitors in Singapore. We then consider the application of non-linear ARDL (NARDL) models in order to explore whether the non-existence of the long-run connection is due to the non-linear structure of the variables.

Method: We use monthly data which range from January 1995 to December 2022 yielding a total of 336 observations. All the data on average room rate and total tourist arrivals are retrieved from Thomson Reuters DataStream database. The starting period of the data used in our empirical analysis is dictated by data availability.

Results and Discussion: The findings reveal that the NARDL model successfully detects the aforesaid association between the variables under consideration. Furthermore, adopting the Toda–Yamamoto test for Granger causality suggests a strong bidirectional short-run connection between these two variables.

Research Implications: Policymakers could utilize these outcomes to implement appropriate strategies (e.g., stabilizing the hotel prices, rebranding the country as an attractive destination) for receiving significant attention from international tourists.

Originality/Value: Although Singapore has been one of the major destinations for international tourists over the years, assessing the relationship between average hotel prices and the total number tourists visiting Singapore does not receive much attention in earlier studies. This study aims to extend such scarce literature.
A longitudinal study on SARS-CoV-2 seroconversion, reinfection and neutralisation spanning several variant waves and vaccination campaigns, Heinsberg, Germany, April 2020 to November 2022
Authors: Schulte Bianca , Richter Enrico , Büning Antonia , Baum Maximilian , Breuer Annika , Zorn Jasmin , König Julia , Geiger Melanie , Eschbach-Bludau Monika , Heuser Johanna , Zölzer Dominik , Korencak Marek , Hollstein Ronja , Beins Eva , Emmert Dorian , Aldabbagh Souhaib , Eis-Hübinger Anna Maria , Streeck Hendrik 
Published: June 2024

Background
Since its emergence in December 2019, over 700 million people worldwide have been infected with SARS-CoV-2 up to May 2024. While early rollout of mRNA vaccines against COVID-19 has saved many lives, there was increasing immune escape of new virus variants. Longitudinal monitoring of population-wide SARS-CoV-2 antibody responses from regular sample collection irrespective of symptoms provides representative data on infection and seroconversion/seroreversion rates.

Aim
To examine adaptive and cellular immune responses of a German SARS-CoV-2 outbreak cohort through several waves of infection with different virus variants.

Methods
Utilising a 31-month longitudinal seroepidemiological study (n = 1,446; mean age: 50 years, range: 2–103) initiated during the first SARS-CoV-2 superspreading event (February 2020) in Heinsberg, Germany, we analysed acute infection, seroconversion and virus neutralisation at five follow-up visits between October 2020 and November 2022; cellular and cross-protective immunity against SARS-CoV-2 Omicron variants were also examined.

Results
SARS-CoV-2 spike (S)-specific IgAs decreased shortly after infection, while IgGs remained stable. Both increased significantly after vaccination. We predict an 18-month half-life of S IgGs upon infection. Nucleocapsid (N)-specific responses declined over 12 months post-infection but increased (p < 0.0001) during Omicron. Frequencies of SARS-CoV-2-specific TNF-alpha+/IFN-gamma+ CD4+  T-cells declined over 12 months after infection (p < 0.01). SARS-CoV-2 S antibodies and neutralisation titres were highest in triple-vaccinated participants infected between April 2021 and November 2022 compared with infections between April 2020 and January 2021. Cross neutralisation against Omicron BQ.1.18 and XBB.1.5 was very low in all groups.

Conclusion
Infection and/or vaccination did not provide the population with cross-protection against Omicron variants.
El acceso a los mecanismos alternativos de solución de controversias en el Sistema Integral de Justicia Penal para Adolescentes en México
Authors: Montoya González Roberto , Steele Garza José Guadalupe 
Published: June 2024

Existe evidencia empírica sobre la incipiente evolución del sistema de justicia restaurativa para adolescentes, esto se debe fundamentalmente a su desconocimiento, especialización y a la falta de sensibilidad en su aplicación de los operadores del derecho y a sus intervinientes en contacto con la ley. No obstante, el sistema tiene un reconocimiento internacional por la eficacia en sus resultados al ser un derecho humano establecido en la Constitución Política de los Estados Unidos Mexicanos y normas jurídicas sustantivas y adjetivas.
La instrumentación eficiente, de la mediación y de las prácticas restaurativas en sede ministerial, judicial y en la etapa de ejecución de medidas de sanción, o incluyendo la salida alterna de suspensión condicional del proceso, es un nuevo escenario, donde se privilegia la autocomposición y el empoderamiento de los participantes, destacando en la presente investigación un arquetipo en la forma de impartir justicia con sentido humanista, que contribuye a la eficacia del sistema que se reflejan en los acuerdos reparatorios, aunado a la reflexión, la armonización y la paz social.
PELATIHAN KERAJINAN LIMBAH KERTAS KORAN BAGI GENERASI MUDA DI KELURAHAN BENTENG, KECAMATAN NUSANIWE, KOTA AMBON
Authors: Leiwakabessy Christoffol , Iswadi Iswadi Iswadi , Maspaitella Cindy  Maspaitella Vithazia , Latumeten Syerin Novella , Latupeirissa Pricilia Owyneth M , Ririhena Rhony Einstein , Patty Jacob Richard , Jambormias Edizon 
Published: June 2024

Semakin meningkatnya konsumsi berita dan informasi yang tersebar luas di seluruh kota membuat koran bekas sendiri menjadi limbah yang melimpah, akan tetapi tidak diimbangi dengan solusi yang bisa menjadikan benda ini menjadi kerajinan yang dapat bernilai ekonomis cukup tinggi. Pengabdian ini bertujuan meningkatkan minat dan peran serta kaum generasi muda dalam menekuni keterampilan ini dan menjadikannya sebagai sumber pendapatan keluarga di Kelurahan Benteng, Kota Ambon. Metode pelatihan yang digunakan ialah pengumpulan data secara kualitatif melalui wawancara, sedangkan strategi pengembangan kerajinan ini adalah studi literatur, observasi, dan wawancara. Dengan pelatihan ini diharapkan generasi muda bisa mendapatkan pengetahuan dan keterampilan sehingga bisa diaplikasikan dalam kehidupan nyata. Hasil akhirnya diharapkan kegiatan ini dapat memberikan kontribusi bagi peningkatkan kesejahteraan keluarga melalui inovasi dan pemasaran produk kerajinan ini.
LAYANAN PEMERIKSAAN LABORATORIUM MEDIS DASAR SEBAGAI UPAYA DETEKSI DINI SINDROM METABOLIK WARGA TIAL BARU DESA SULI KECAMATAN SALAHUTU
Authors: Orno Theosobia Grace , Madiuw Devita , Lenderts Elita Stephanie 
Published: June 2024

Sindrom metabolik merupakan faktor predisposisi terjadinya diabetes melitus dan penyakit jantung yang ditandai dengan obesitas sentral, hipertensi, hiperglikemia, serta dislipidemia. Kegiatan ini bertujuan untuk memberikan layanan pemeriksaan laboratorium medis dasar untuk deteksi sindrom metabolik bagi warga Tial Baru Desa Suli Kecamatan Salahutu. Sesuai kriteria National Cholesterol Education Program- Adult Treatment Panel III Cholesterol disimpulkan bahwa sebanyak 59% warga mengalami sindrom metabolik berdasarkan pada hasil pengukuran lingkar perut, tekanan darah serta kadar glukosa darah puasa. Disarankan kepada masyarakat untuk memperbaiki pola hidup dengan cara mengontrol asupan gizi, mengatur pola aktivitas fisik serta manajeman stres.
PERSPEKTIF PEMUDA TERHADAP USAHA BUDIDAYA IKAN KERAPU (Epinephelus Sp) DI KOTA AMBON
Authors: Rahayu Sri Panca , Mosse Jacobus Wilson , Apituley Yolanda M. T. N 
Published: June 2024

Ambon City is part of the Maluku Province which has very potential fisheries resources and also human resources (youth) who are expected to participate in the development of the aquaculture sector. The role of youth as the next generation is expected to be able to form perspectives in developing aquaculture businesses in the future, for this reason this research was conducted to analyze youth perspectives on grouper (Ephinephelus Sp) aquaculture in Ambon City. The sampling method for viewing youth perspectives in this study is the purposive sampling method (Sugiyono, 2015), which measures youth perspectives using a Likert Scale (Sugiyono, 2010). With a Likert Scale, the variables to be measured are translated into variable indicators (perspective of basic knowledge, cultivation techniques, interest in cultivation and cultivation business development). Based result using the likert scale that the youth’s knowledge in groupe cultivation is a very high with youth interval who involved is 2,91 more higher than youth who not involved 2,43. Tecnical knowledge about cultivation is olso higt. Youth involved knowledge about cultivation youth involved in cultivation 2,66, inversely propotional with youth who not involved in cultivation be on 1,59. Youth interest with groupe cultivation get an higher presentage 2,71 and who not interested 2,35 and related with grouper cultivation development in the future have rank 2,67 compared to the uninvolved 1,68. Generally the total number from whole perspective comparison between youth with the grouper cultivation development in Ambon is already high with interval precentege 2,40.
Literacy Skills of Students in a Remote Area
Authors: Ramayanti Rory , Iranda Agung , Yusufhin Fridinanti 
Published: June 2024

Purpose Research. The research objective was to identify the literacy skills of Merangin 53 Remote Junior High School students. Research Method. This study used a qualitative method with an ethnographic approach. The data were collected through interviews, observation, and documentation. Analysis Data. The Spradley model was used in the analysis. The analysis steps consisted of determining participants, interviewing, making an ethnographic record, asking descriptive questions, analyzing the interviews, making a domain analysis, asking structural questions, making a taxonomic analysis, asking contrast questions, discovering cultural themes, and writing an ethnography Results. Literacy topics of Merangin 53 Junior High School students encompassed access to information, lack of literacy skills, literacy learning methods that rely on the teacher, guidance and mentoring, and literacy for effective school activity. Conclusions. Some topics collected from literacy skills included the influence of culture and the situation in the remote school. Some influences on literacy skills encompassed difficult access to roads, internet connections, transportation, and students' socioeconomic conditions. Keywords: Information literacy, remote school, Merangin