bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working with ‘hands‐off’ support: a qualitative study of multidisciplinary teams’ experiences of home rehabilitation for older people
Authors: Randström Kerstin Björkman , Wengler Yvonne , Asplund Kenneth , Svedlund Marianne 
Published: December 2012

BackgroundThere is a move towards the provision of rehabilitation for older people in their homes. It is essential to ensure that rehabilitation services promote independence of older people.AimThe aim of the study was to explore multidisciplinary teams' experiences of home rehabilitation for older people.MethodsFive focus groups were conducted with multidisciplinary teams based in a municipality in Sweden, covering seven different professions. In total, 28 participants volunteered to participate in these interviews. Interviews were transcribed verbatim and analysed according to content analysis.ResultsTwo main categories, as well as four subcategories, emerged. The first main category, having a rehabilitative approach in everyday life, consisted of the subcategories: ‘giving ‘hands‐off’ support’ and ‘being in a home environment’. The second main category, working across professional boundaries, consisted of the subcategories: ‘coordinating resources’ and ‘learning from each other’.ConclusionCommon goals, communication skills and role understanding contributed to facilitating the teams' performances of rehabilitation. A potential benefit of home rehabilitation, because the older person is in a familiar environment, is to work a rehabilitative approach into each individual's activity in their everyday life in order to meet their specific needs. At an organisational level, there is a need for developing services to further support older people's psychosocial needs during rehabilitation.Implications for practiceTeam performance towards an individual's rehabilitation should come from an emerged whole and not only from the performance of a specific professional approach depending on the traditional role of each profession. A rehabilitative approach is based on ‘hands‐off’ support in order to incorporate an individual's everyday activities as a part of their rehabilitation.
Unicystic ameloblastoma mimicking a lateral periodontal cyst
Authors: Majid O.W. 
Published: December 2012

AbstractUnicystic ameloblastoma (UA) is a subtype that represents 5–22% of all ameloblastoma types. In this report, a 41‐year‐old patient is presented with a swelling in the right side of the mouth since 2 months with no facial disfigurement. On clinical examination, a firm non‐tender mass bulging between the right lower first and second premolars. Fine‐needle aspiration yielded only little non‐specific fluid. A panoramic radiograph was taken, which showed a large well‐defined radiolucency measured about 3.5 cm in diameter resembling a lateral periodontal cyst. The lesion was totally removed by surgical enucleation under local anaesthesia. The histopathological examination confirmed the diagnosis of UA of mural type. The patient was informed of the prognosis and put on periodic follow‐up.
Identification of PCR markers linked to different Or genes in sunflower
Authors: Imerovski Ivana , Dimitrijevic Aleksandra , Miladinovic Dragana , Dedic Bosko , Jocic Sinisa , Kovacevic Branislav , Obreht Dragana 
Published: December 2012

AbstractBroomrape is a parasitic plant that significantly decreases yield of sunflower. Breeding for resistance has proved to be the most efficient method for suppressing broomrape infestation in the field; however, new races of parasite constantly emerge, and new resistance genes need to be discovered and introduced into cultivated sunflower lines. The aim of this work was to test SSR markers from linkage group 3 (LG3) to investigate whether they could be used for identification of a particular Or gene. Twenty sunflower inbred lines were used, and polymorphism between the lines with various resistance genes and genetic background was investigated. The used markers revealed DNA polymorphism between the investigated lines. Strong association of markers from LG3 with Or6, as well as Or4 and Or2 genes, was found. Identified markers could be used for introduction of these resistance genes into commercial sunflower lines and for establishment and identification of differential lines.
Acute disseminated encephalomyelitis after allogeneic bone marrow transplantation for pure red cell aplasia – A case report and review of the literature
Authors: Paisiou Anna , Goussetis Evgenios , Dimopoulou Maria , Kitra Vassiliki , Peristeri Ioulia , Vessalas Giorgos , Gavra Maria , Theodorou Virginia A. , Graphakos Stelios 
Published: December 2012

AbstractADEM is a rare inflammatory demyelinating disease of the CNS, which usually presents after a viral infection or a vaccination. We report a 15‐yr‐old boy who was diagnosed with ADEM after an HLA‐identical sibling allogeneic BMT for transfusion‐dependent PRCA. His course was complicated with GVHD affecting the skin and lungs. Five months post‐BMT, he developed neurological symptoms including sudden mental status alteration, dysarthria, facial nerve palsy, and acute paraplegia. The MRI revealed multifocal hyperintense lesions mainly in the subcortical white matter of the cerebrum, the brainstem, the basal ganglia, and the thalami. CSF examination was normal. There was no laboratory evidence of infection. The typical MRI findings and an acute monophasic clinical course were consistent with the diagnosis of ADEM. Clinical and radiological improvement was observed after treatment with high‐dose steroids and IVIG. Complete neurologic recovery was achieved six months after the onset of symptoms. We present a rare case of ADEM post‐BMT and review of the literature.
Lung transplantation in children following bone marrow transplantation: A multi‐center experience
Authors: Yousef S. , Benden C. , Boyer D. , Elidemir O. , Frischer T. , Goldfarb S. , Lopez‐Mitnik G. , Mallory G. , Visner G. , Westall G. , Schecter M. G. 
Published: December 2012

AbstractAllogenic BMT has been successfully performed as a treatment for hematologic diseases with an expected long‐term survival. This survival is truncated by respiratory complications including airway obstruction especially BO. Chronic GVHD has been reported to precede almost all cases reported. LTx has become a therapeutic life‐saving option for patients with end‐stage lung disease that maybe offered for the treatment of GVHD. We report a multi‐center experience of pediatric LTx following BMT in 11 patients age‐ and gender‐matched with 11 controls who received LTx for end‐stage lung disease secondary to CF. Overall death was 36.4% over a follow‐up period of 19 months (range 3–36 months) for the cases and 27.3% for the control group followed for 17 months (range 8–32 months). Median FEV1 one yr post‐transplant for the cases was 78% predicted compared with 67.3% predicted for the controls. The median for episodes of infection was comparable at a median of one episode per patient through the entire follow‐up period among both groups. Acute rejection episodes were significantly higher in the control group with a median of one episode per patient in the control group compared to none within the cases. Our data suggest that LTx may be a valuable therapeutic option for children with end‐stage lung disease post‐BMT with comparable survival outcome to that after LTx in children for other indications such as CF. Hospital stay was significantly longer in our case group. Infection rate was comparable between groups albeit type of infection varied. Significantly and of interest is that acute rejection episodes were non‐existent in these cases.
Three Cheers for Double Effect
Authors: Nelkin Dana Kay , Rickless Samuel c. 
Published: December 2012

Abstract
The doctrine of double effect, together with other moral principles that appeal to the intentions of moral agents, has come under attack from many directions in recent years, as have a variety of rationales that have been given in favor of it. In this paper, our aim is to develop, defend, and provide a new theoretical rationale for a secular version of the doctrine. Following Quinn (1989), we distinguish between Harmful Direct Agency and Harmful Indirect Agency. We propose the following version of the doctrine: that in cases in which harm must come to some in order to achieve a good (and is the least costly of possible harms necessary), the agent foresees the harm, and all other things are equal, a stronger case is needed to justify Harmful Direct Agency than to justify Harmful Indirect Agency. We distinguish between two Kantian rationales that might be given for the doctrine, a “dependent right” rationale, defended by Quinn, and an “independent right” rationale, which we defend. We argue that the doctrine and the “independent right” rationale for it are not vulnerable to counterexamples or counterproposals, and conclude by drawing implications for the larger debate over whether agents' intentions are in any way relevant to permissibility and obligation.
The Assessment of Elaborated Role‐play in Young Children: Invisible Friends, Personified Objects, and Pretend Identities
Authors: Taylor Marjorie , Sachet Alison B. , Maring Bayta L. , Mannering Anne M. 
Published: December 2012

AbstractRole‐play (i.e., pretending in which children imagine and act out the part of another individual) was assessed with child interviews and parent questionnaires about invisible friends, personified objects, and pretend identities in a sample of 208 young children. Children who engaged in role‐play did not differ from other children in age or vocabulary comprehension. However, they were better able to generate a pretend conversation than other children and were rated by their parents as less shy. The overall pattern of results suggests that the capacity to interact with imaginary others (in and out of the lab) is more closely associated with individual differences in personality than developmental level.
Identification of bovine leukocyte antigen class II haplotypes associated with variations in bovine leukemia virus proviral load in Japanese Black cattle
Authors: Miyasaka T. , Takeshima S.‐n. , Jimba M. , Matsumoto Y. , Kobayashi N. , Matsuhashi T. , Sentsui H. , Aida Y. 
Published: December 2012

AbstractBovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis, which is the most common neoplastic disease of cattle. Bovine leukocyte antigen (BoLA) is strongly involved in the subclinical progression of BLV infections. Recent studies show that the BoLA‐DRB3 gene might play a direct role in controlling the number of BLV‐infected peripheral B lymphocytes in vivo in Holstein cattle. However, the specific BoLA class II allele and DRB3‐DQA1 haplotypes determining the BLV proviral load in Japanese Black cattle are yet to be identified. In this study, we focused on the association of BLV proviral load and polymorphism of BoLA class II in Japanese Black cattle. We genotyped 186 BLV‐infected, clinically normal cattle for BoLA‐DRB3 and BoLA‐DQA1 using a polymerase chain reaction‐sequence‐based typing method. BoLA‐DRB3*0902 and BoLA‐DRB3*1101 were associated with a low proviral load (LPVL), and BoLA‐DRB3*1601 was associated with a high proviral load (HPVL). Furthermore, BoLA‐DQA1*0204 and BoLA‐DQA1*10012 were related to LPVL and HPVL, respectively. Furthermore, we confirmed the correlation between the DRB3‐DQA1 haplotype and BLV proviral load. Two haplotypes, namely 0902B or C (DRB3*0902‐DQA1*0204) and 1101A (DRB3*1101‐DQA1*10011), were associated with a low BLV proviral load, whereas one haplotype 1601B (DRB3*1601‐DQA1*10012) was associated with a high BLV proviral load. We conclude that resistance is a dominant trait and susceptibility is a recessive trait. Additionally, resistant alleles were common between Japanese Black and Holstein cattle, and susceptible alleles differed. This is the first report to identify an association between the DRB3‐DQA1 haplotype and variations in BLV proviral load.
Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs
Authors: Hamoudi Hassan , Rudnick Jens‐Christian , Prause Jan U. , Tauscher Kerstin , Breithaupt Angele , Teifke Jens P. , Heegaard Steffen 
Published: December 2012

AbstractTwo sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.
Characteristics of the total disintegration events of emulsion heavy target nuclei caused by O16 and 28Si nuclei at high energies
Authors: Mohery Mahmoud 
Published: December 2012

The present paper deals with the interactions of 16O and 28Si nuclei with emulsion heavy target nuclei (silver (Ag) and bromine (Br)) at 4.5A GeV/c. The results have been analyzed to identify interesting characteristics of the total disintegration (TD) events produced in these interactions. Events having a number of heavily ionizing particles Nh ≥ 28 have been selected in this study. The integral multiplicity distributions for the disintegrated particles from the target nuclei have been used to separate the inelastic interactions with the free hydrogen (H), the light (CNO), and the heavy (AgBr) nuclei. The average multiplicities of the different secondary particles emitted in these interactions have been compared with the corresponding ones of different projectiles nearly at the same momentum. The average multiplicity of the grey particles is found to increase with the mass of the projectile, while the average multiplicity of the black particles is found to decrease with increasing mass of the projectile; this result agrees with the prediction of the fireball model. Also, the dependence of the shower, grey, and black particles produced in the TD events on the mass of the projectile has been studied. Moreover, the dependence of the probability of the TD for the projectile mass as well as the target fragments has also been discussed. The results show that the multiplicity distributions of the shower, grey, and black particles present a Gaussian distribution. Finally, the linear dependence of the grey and compound multiplicities on the black, heavy, and shower particles has also been observed.
A Phase II Study of Sorafenib in Patients with Platinum-Pretreated, Advanced (Stage IIIb or IV) Non–Small Cell Lung Cancer with a KRAS Mutation
Authors: Dingemans Anne-Marie C. , Mellema Wouter W. , Groen Harry J.M. , van Wijk Atie , Burgers Sjaak A. , Kunst Peter W.A. , Thunnissen Erik , Heideman Danielle A.M. , Smit Egbert F. 
Published: December 2012

Abstract
Purpose: Sorafenib inhibits the Ras/Raf pathway, which is overactive in cancer patients with a KRAS mutation. We hypothesized that patients with non–small cell lung cancer (NSCLC) with KRAS mutation will benefit from treatment with sorafenib.
Experimental Design: In this phase II study, patients with KRAS-mutated, stage IIIb or IV NSCLC that progressed after at least one platinum-containing regimen were treated with sorafenib. Treatment consisted of sorafenib 400 mg twice daily until disease progression or unacceptable toxicity. Pretreatment serum from each patient was obtained to predict outcome using a proteomic assay (VeriStrat). Primary endpoint was disease control rate (DCR) at 6 weeks.
Results: Fifty-nine patients were entered between May 2010 and February 2011. Fifty-seven patients started sorafenib. Mean age was 58.5 (SD = ±8.1) years, 16 male/41 female, Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0/1/2 24/30/3. At 6 weeks, 5 partial response, 25 stable disease, and 27 progressive disease were observed; DCR was 52.6%. Median duration of treatment was 9 weeks. The median progression-free survival (PFS) was 2.3 months and median overall survival (OS) was 5.3 months. Patients with a prediction of good prognosis according to VeriStrat serum proteomics assay showed a significantly superior PFS [HR, 1.4; 95% confidence interval (CI), 1.0–1.9] but not OS (HR, 1.3; 95% CI, 0.9–1.7). Sorafenib-related grade III/IV toxicity was reported in 10 patients (17.5%); all but one patient experienced grade III skin toxicity (14.0%) or grade III gastrointestinal toxicity (8.8%).
Conclusion: Treatment with sorafenib has relevant clinical activity in patients with NSCLC harboring KRAS mutations. Further randomized study with this agent is warranted as single-agent or combination therapy. Clin Cancer Res; 19(3); 743–51. ©2012 AACR.
Hyperreactive platelet phenotypes: Relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation
Authors: Becker Richard C. , Dentali Francesco , Kuhn Cynthia , Helms Michael J. , Ortel Thomas L. , Williams Redford , Berger Jeffrey S. 
Published: December 2012

SummaryThe mechanism underlying a hyperreactive platelet phenotype remains unknown. Since serotonin has been shown to influence platelet biology and atherothrombosis, we sought to investigate the association of platelet serotonin transporter number, binding affinity, and uptake kinetics with platelet aggregation. A total of 542 healthy volunteers had light transmittance platelet aggregometry measured in response to varying concentrations of epinephrine, serotonin, epinephrine plus serotonin, ADP and collagen. Transporter-dependent serotonin uptake rate was determined (Vmax), as were serotonin transporter number (Bmax) and binding affinity (Kd) using 3H paroxetine binding in a homologous displacement assay, nonlinear regression and validated algorithms for kinetic modelling. Stimulation with submaximal (2μM) epinephrine concentration elicited a distinct, bimodal pattern of platelet aggregation in this population. In contrast, subjects exhibited minimal aggregation in response to serotonin alone. Co-stimulation with submaximal epinephrine and serotonin induced platelet aggregation to a level beyond that observed with either agonist alone and maintained a bimodal response distribution. Subjects with heightened (>60%) platelet aggregation to both epinephrine alone and epinephrine plus serotonin exhibited increased platelet serotonin uptake, and transporter number and affinity. In a population of healthy subjects, co-stimulation with submaximal concentrations of epinephrine and serotonin identifies a subset of individuals with a hyperreactive platelet aggregation profile that is associated with changes in platelet serotonin function.
Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: Insights from the switching anti-platelet (SWAP) study
Authors: Angiolillo Dominick , DeRaad Roger , Frelinger Andrew , Gurbel Paul , Costigan Timothy , Jakubowski Joseph , Ojeh Clement , Duvvuru Suman , Effron Mark , Saucedo Jorge ,   for the SWAP Investigators
Published: December 2012

SummaryThe prevalence of high platelet reactivity (HPR) in patients who have switched from clopidogrel to prasugrel during maintenance phase after an acute coronary syndrome (ACS) event is unknown. Therefore, the effect of switching from clopidogrel to prasugrel on the prevalence of HPR was evaluated. This analysis from the previously reported SWAP (SWitching Anti Platelet) study assessed HPR at baseline, 2 and 24 hours, and seven days after switching from clopidogrel to prasugrel maintenance dose (MD), with or without a prasugrel loading dose (LD) using four definitions: maximum platelet aggregation (MPA) >65% (primary endpoint), MPA >50%, P2Y12 reaction units (PRU) >235, and platelet reactivity index (PRI) ≥50%. A total of 95 patients were available for analysis; 56 patients provided DNA for genetic assessments of cytochrome P450 (CYP) 2C19. There were 26 (27.4%) patients with HPR at the end of the clopidogrel run-in (defined as MPA >65%). The HPR prevalence varied by each definition and ranged from 19% (PRU >235) to 68% (PRI ≥50%). A significantly higher HPR prevalence was observed during clopidogrel versus the combined prasugrel therapy groups at seven days as measured by MPA >65% (21.2% vs. 4.5%, p>0.05), PRU >235 (18.8% vs. 0%, p=0.001), and PRI ≥50% (66.7% vs. 7.9%, p<0.0001). There was a significantly higher percentage of subjects carrying at least one reduced function allele with HPR measured by MPA >65% (p=0.02) or PRU >235 (p=0.05) than non-carriers with HPR. Switching ACS patients during maintenance clopidogrel therapy to prasugrel with or without an LD is associated with a reduced HPR prevalence and may provide an alternative strategy to treat patients with HPR, independent of CYP2C19 genotype.
The short- and long-term risk of venous thromboembolism in patients with acute spinal cord injury
Authors: Donadini Marco P. , Dentali Francesco , Ageno Walter , Marazzi Marina , Bocchi Romeo , Imberti Davide , Pierfranceschi Matteo Giorgi 
Published: December 2012

SummaryVenous thromboembolism (VTE) is a frequent complication in the acute setting after spinal cord injury (SCI). Less is known about the long-term risk of VTE in these patients. It was the aim of this study to prospectively evaluate the short- and long-term risk of VTE in a cohort of patients after acute SCI and during rehabilitation and post-rehabilitation follow-up period. From January 2003 to November 2007 all consecutive adult patients admitted to a Spinal Rehabilitation Unit (RU) after surgical treatment in three Neurosurgical Units for SCI, were enrolled. After an accurate evaluation of their neurosurgical medical records the patients were prospectively evaluated for VTE occurrence. Ninety-four patients (80 males; mean age 40.3 years, SD 15.9) were recruited. All the patients received thromboprophylaxis with low-molecular-weight heparin combined with compressive stockings during hospitalization (median duration 7 months, IQR 4.5–8.8). Over a median follow-up period of 36.3 months (IQR 4.4–48) after SCI, VTE was diagnosed in 22 patients (23.4%) The majority of VTE events were recorded during the first three months of follow-up (34.4 VTE events/100 patient-years in the first 3 months and 0.3 VTE events/100 patient-years thereafter); age over 45 years (HR 8.4, 95% CI 3–23.5), previous VTE (HR 6.0, 95% CI 1.6–23.3) and paraplegia (HR 4.7, 95% CI 1.6–13.7) were independently associated with the occurrence of VTE. In conclusion, the risk of VTE in patients suffering from SCI is high despite the use of thromboprophylaxis, in particular in some patients categories. However, this risk appears to be limited to the first 3 months after the index event.