bluuebunny/crossref_metadata_2025_split huggingface dataset:
1597 – Alterations In Serotonin Transporter Asymmetry In Male-to-female Transsexuals Measured By Brain Pet
Authors: Kranz G.S. , Hahn A. , Haeusler D. , Philippe C. , Kaufmann U. , Wadsak W. , Mitterhauser M. , Kasper S. , Lanzenberger R. 
Published: July 2013

IntroductionThe serotonergic system modulates brain functions that are considered to underlie affective states, emotion and cognition. Several lines of evidence point towards a strong lateralization of these mental processes, indicating similar asymmetries in associated neurotransmitter systems.ObjectivesTo investigate a potential brain asymmetry of the serotonin transporter (SERT) distribution using Positron Emission Tomography (PET).AimsAs brain asymmetries differ between sexes, we aimed to compare serotonin transporter asymmetry between females, males and male-to-female transsexuals whose brains are considered to be partly feminized.Methods36 subjects aged 19-54 years (9 female controls, 13 male controls and 14 male-to-female transsexuals) were measured with PET and [11C]DASB. Whole-brain voxel-wise SERT binding potential (BPND) maps were computed using a tracer-specific symmetric template. Statistics comprised repeated measures ANOVA with group as the between subjects factor, voxel-wise SERT asymmetry as repeated factor and group*asymmetry as interaction term.ResultsSERT binding in all groups showed both strong left and rightward asymmetries in several cortical and subcortical structures including temporal and frontal cortices, anterior cingulate, hippocampus, caudate and thalamus (p< 0.05 FDRcorrected). Further, male controls showed a rightward asymmetry in the midcingulate cortex (p>0.05 FDR-corrected) which was absent in females and male-to-female transsexuals.ConclusionsOur data support the notion of a lateralized serotonergic system, which is in line with previous findings of asymmetric serotonin-1A receptor distributions, extracellular serotonin concentrations, serotonin turnover and uptake. The absence of serotonin transporter asymmetry in the midcingulate in male-to-female transsexuals may be attributed to an absence of brain masculinization in this region.
1602 – Longitudinal Studies On Associations Between Use Of Antipsychotics And Brain Morphometric Changes In Schizophrenia - a Systematic Review
Authors: Huhtaniska S. , Jääskeläinen E. , Hirvonen N. , Remes J. , Murray G. , Veijola J. , Isohanni M. , Miettunen J. 
Published: July 2013

IntroductionRelatively little is known on longitudinal effects of antipsychotic medication on brain morphometry in schizophrenia after the illness onset. There are inconsistent findings on medication effects on brain structures.ObjectivesWe will study the effect of antipsychotic medication on brain volumes in schizophrenia.AimsThe aim of the current study was to systematically review previous literature on longitudinal MRI studies of antipsychotic effects on brain morphometric changes in schizophrenia and related psychoses.MethodsStudies were systematically collected using four different databases. A study was included if subjects were scanned twice, the average scanning interval was at least two years and antipsychotic medication data was used to predict morphometric changes. The studies focused on several different brain areas; we categorized these into eleven larger areas.ResultsIn total 22 studies fulfilled our inclusion criteria. The main finding of our study was that most of the reported correlations were statistically non-significant. The significant associations between antipsychotic use and brain changes were reported from various areas. In the studies with significant findings, use of antipsychotics more often associated with decrease than increase of brain volumes, even in the very few studies taking into account illness severity.ConclusionsAntipsychotic medication should be adjusted to lowest possible dose for reducing psychotic symptoms and prescribed with caution especially to people not suffering from psychosis. More studies in different kind of patient populations are needed to clarify the possible adverse effect antipsychotic medication may have on brain structure.
1607 – Impaired Subjective Sleep Quality In Irritable Bowel Syndrome Patients With a Type d Personality
Authors: Yıldırım O. , Alçelik A. , Canan F. , Aktaş G. , Şit M. , İşçi A. , Yalçın A. , Yılmaz E.E. 
Published: July 2013

IntroductionType D (distressed) personality is defined as the co-occurrence of negative affect (NA) and social inhibition (SI).ObjectivesAlthough many studies have analyzed the association of irritable bowel syndrome (IBS) and personality traits, the effect of Type D personality on sleep quality of patients with IBS has not been evaluated.AimsWe aimed to assess the prevalence of Type D personality in patients with and to investigate whether the presence of a Type D personality would affect subjective sleep quality in patients with IBS.MethodsNinety-seven patients who met the Rome III criteria for IBS with no psychiatric comorbidity were consecutively enrolled, along with 39 healthy controls. Type D Scale, Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale were used in the collection of data.ResultsOf 97 patients evaluated, 45.4% met criteria for Type D personality. Thirty-five patients (36.1%) and 7 healthy volunteers (17.9%) were “poor” sleepers (p< 0.05). IBS patients with a Type D personality were found to score higher on sleep latency, sleep disturbance, and global sleep quality domains of PSQI than patients without a Type D personality. Poor sleeping was more prevalent among patients with a Type D personality than those without (50.0% vs 33.9%; p < 0.01). Linear regression analysis revealed a significant independent association of Type D personality with poor sleeping (r = 0.315; p < 0.01).ConclusionType D personality was associated with decreased perceived sleep quality in patients with IBS.
1609 – How First- And Second-generation Antipsychotics Differentially Improve Anterior Cingulate Cortex (acc) Function In Schizophrenic Patients - An Event-related Potential Study
Authors: Schneider S. , Bahmer T. , Metzger F. , Reif A. , Polak T. , Walter G. , Eberle M.-C. , Fallgatter A.J. , Ehlis A.-C. 
Published: July 2013

Introduction/objectivesSecond-generation antipsychotics (SGAs) are a frequently and effectively used treatment in schizophrenia and psychotic disorders. Other than First-generation antipsychotics (FGAs), which mainly exert their pharmacologic effect in subcortical dopaminergic systems, SGAs additionally affect partly serotonergically innervated structures within prefrontal areas, such as the Anterior Cingulate Cortex (ACC). However, only few controlled, randomized studies have so far investigated direct and indirect effects of SGAs on the ACC.AimsThe present study investigated differential effects of one SGA (quetiapine) and one FGA (flupentixol) on the human action monitoring system.MethodsACC function in 18 quetiapine-medicated patients and 13 flupentixol-treated patients suffering from schizophrenia was assessed by means of the error-related negativity (ERN), a neurophysiological marker of ACC function, in a pre-post design. Results Between-group comparisons revealed different effects of quetiapine and flupentixol on ACC function despite similar improvement in psychopathology, cognitive performance and quality of life. Whereas SGA treatment was associated with an increase in amplitudes over time, there were prolonged ERN peak latencies in patients treated with the FGA. Moreover, treatment effects depended on baseline PFC function in both groups.ConclusionsWe conclude that both flupentixol and quetiapine improve prefrontal function especially in patients with weak initial ACC function which might be due to their shared affinity for 5HT-receptors in frontal brain regions. However, since this affinity is more pronounced for SGAs, patients treated with quetiapine seemed to profit more evidently concerning PFC function compared to patients of the flupentixol group, who exhibited a compensatory prolongation of processes.
1611 – Opiate Substitution Therapy: a Retrospective Study Of An 11-year Follow-up Depending On The Given Treatment: Methadone And/or Buprenorphine
Authors: Gay A. , Sigaud T. , Chesnoy G. , Billard S. , Lang F. 
Published: July 2013

IntroductionAfter 50 years of international experience and 15 years of use in France, the positive impact of drug replacement treatments on the care of patients with opiates dependence is now well established. Even though there is a vast literature on the two existing treatments (methadone and high-dosage buprenorphine), few works have focused on patients who have changed replacement therapy during follow-up.Objectives and aimsThe aim of our study was to analyze the follow-up of substituted patients throughout an 11-year period. Patients were characterized by the type of treatment: methadone only, high-dosage buprenorphine only, or both treatments.MethodsThese groups of patients were studied depending on their characteristics at the beginning of the treatment (sociodemographic data, addictive behaviours, psychiatric assessment) and in terms of healthcare and follow-up regularity. We also tried to bring to light predictive factors of unstable follow-ups at the point of entry in healthcare.Results891 patients were included in our results. Patients having had two substitution treatments initially present with higher severity in terms of socio-professional integration, addictive behaviours and psychiatric comorbidity. Their treatment is more discontinued and they have longer healthcare.ConclusionsPsychiatric comorbidities and poly-drug use seem to characterize unstable patients who jeopardize our treatments. They have to be identified very early in order to better adjust healthcare. This preliminary work underlines the necessity of carrying out a prospective study integrating better adapted assessment tools.
1616 – New Psychoactive Substances-herbal Smoke Mixtures. Prevalence And Problems In Latvia
Authors: Stirna A. , Skaida S. , Caune M. 
Published: July 2013

ObjectivesThe aim of the survey is to obtain an overview of the trends in the use of herbal smoke mixtures or “Spice” among clients and the specific nature of impairments associated with them.Materials and methodsData on the use of “Spice” and cannabinoids have been analysed through clinical observations carried out at the Centre for Addiction Medicine and performance results of the Centre for Expertise and Toxicology over 41 months between 2009 and 2012 based on 257 individuals. Diagnosis was based on clinical and laboratory data. New psychoactive substances were identified in urine and blood, and express tests for “spice” were carried out through biochip matrix technology.ResultsIn 2012 a fourfold growth of “Spice” users has been noted as compared to 2009; among them 86.8% were 27 years old and younger and 38.7% were minors. Compared to cannabinoid cases, the individuals hospitalised for acute intoxication with “Spice” statistically more frequently (p< 0.05) suffered from fear, anxiety, panic attacks, agitation, whereas frequency of psychotic manifestations and acute schizophrenia symptoms demonstrated by the two groups were similar. Among the “Spice” cases proved through laboratory testing, 66.7% had signs of intoxication with characteristic, but non-specific symptoms of the vegetative nervous system.ConclusionOver the past years there has been a significant growth in the consumption of “Spice”.The clinical manifestations of “Spice” are not sufficiently typical for detecting the substance without the use of laboratory tests.Safe identification of substances through the use of specific testing methods is required.
1617 – Cognitive Inhibition In Eating Disorders: Self-report Questionnaires Versus Neuropsychological Tests
Authors: Chaib L.S. , Adoue C. , Olie E. , Guillaume S. , Courtet P. 
Published: July 2013

IntroductionSeveral studies have demonstrated various neuropsychological dysfunctions in patients with EDs [1]. Among them, cognitive inhibition deficits has been studied. While Eating Disorders (ED) are characterized by difficulties to inhibit feeding behavior, there is no consensus regarding neuropsychological studies about cognitive inhibition deficits [2, 3]. The goal of this study is to examine the contribution of the type of measurement used (self-report questionnaires versus neuropsychological tests) to explain these differences between studies.MethodPatients (ED) suffering from anorexia nervosa (AN; n=33), bulimia nervosa (BN; n=27) with no psychiatric comorbidity and free of psychotropic medication, and healthy controls (HC; n=xx) with no psychiatric history were assessed using the Hayling Test (neuropsychological test) and BIS-10 (self-report questionnaires).Results[1]Significant differences in self-report questionnaires (BIS-10) were observed between ED and HC. BN showed more pronounced cognitive inhibition deficits then AN.[2]No significant differences in neuropsychological tests (Hayling Test) were observed between ED and HC.ConclusionThis study confirms dissociation between measures of self-report questionnaires and neuropsychological tests of cognitive inhibition and impulsivity in people with ED.
1624 – Prospective Evaluation Of Sensorial Trainings On Body Mass Index In Anorexia Nervosa
Authors: Battista M. , Celse C. 
Published: July 2013

IntroductionIn our medical service specialized in feeding disorders, we observed a loss of sensorial abilites (i.e., olfactory and taste). Since 2006 we proposed to adolescent anorexic patients different sensorial trainings: somesthesic, auditory and olfactory. In this scope of research, the data suggest a rehabituation to smells and taste linked to food stimuli and enhance the remember of events related to feeding behaviors.ObjectivesThe use of this particular way of care focused on the oral area, lead to observe a diminution of hospitalization duration (30%). We propose an evaluation of the therapeutic impact after 6 months and one year on the basis of a main criteria the Body Mass Index.AimsWe expected that the use of a olfactory food stimulus is associated to higher scores of pleasantness judgment and could participate to an adequate treatment of feeding disorders.MethodsTwo groups of patients were submitted to sensorial trainings: somesthesic and auditory vs somesthesic and olfactory. The sensorial trainings are conducted once a week. After 14 weeks several functions are tested (clinical, cognitive and sensorial). Sensorial evaluation consist in several judgment tasks (Liking vs Wanting) about stimuli presented visually or olfactory.ResultsPreliminary results show that olfactory perception enhance the pleasantness judgment of stimuli (e.g., flower or strawberry).
1627 – A French Case Series Of Twenty Synthetic Cathinones Abuse
Authors: Batisse A. , Fortias M. , Sec I. , Grégoire M. , Djezzar S. 
Published: July 2013

IntroductionSynthetic cathinones are becoming increasingly popular and available as legal highs on the internet smartshop. Since July 2012, all synthetic drugs from the cathinones family have been banned and listed as narcotic in France but remain used.ObjectivesTo describe the clinical presentation and alert the health care community about the abuse identification and risk assessment problems of these compounds.MethodsWe retrospectively reviewed cases of cathinone derivatives abuse notified to our Parisian centre during a two-year period (2011-2012).ResultsTwenty cases of cathinones abuse were identified. Users were mostly men (19/20), with mean age of 38 years, showing occasional cathinones abuse in sexual gay party (12/20). The synthetic cathinones were most commonly administered by intravenous injection (75%): an increasingly popular practice among Parisian men who have sex with men (MSM). This practice is called “slam”. This is an especially worrisome trend since the prevalence of HIV infection in our cases were 70% (14/20) with frequent co-infection HIV/Hepatitis C (40%). Thirteen cases presented psychiatric disorders: psychotic symptoms (58%), agitation (37%), anxiety (37%), suicidal ideas (28%) or attempt (2/20), acute satyriasis (2/20). Seven patients presented a cathinones dependence with DSM 4 criteria. Two patients had forensic problems. Somatic complications were described in ten cases with various pattern of symptoms as headache or rhabdomyolysis with renal failure.ConclusionsCathinones cause fast dependence syndrome with strong craving and prolonged psychiatric symptoms. We discuss the relation between sex and drugs in our sample. Cathinones could have a specific effect on sexual drives.
1637 – Recall Of Previously Learned Associations And Memory Generalization In Schizophrenia, Other Psychoses, Siblings, And Controls. The Northern Finland 1966 Birth Cohort Study
Authors: Alaräisänen A. , Kukkohovi L. , Rönkkö E. , Kyllönen M. , Miettunen J. , Isohanni M. , Veijola J. , Tamminga C. 
Published: July 2013

IntroductionNeurocognitive impairments are a core feature of schizophrenia. The medial temporal lobe (MTL) is a brain region associated with declarative memory important in conscious acquisition and recollection of facts and events. The basal ganglia (BG) instead are linked to non-declarative memory functions such as gradual learning of skills and habits.ObjectiveAcquired equivalence (AE) is a phenomenon in which prior training to treat two stimuli as an equivalent increases generalization between them. Our objective was to study this phenomenon in birth cohort setting.AimsTo investigate whether the recall of previously learned associations and memory generalization are declined in schizophrenia, other psychoses and siblings compared to healthy controls.MethodsThe Northern Finland Birth Cohort 1966 is based upon 12, 068 women and their 12, 058 live-born children. The modified Rutger's AE-task was performed for 35 schizophrenia patients, 26 patients suffering from other psychosis, 18 siblings of psychotic subjects and 174 controls.ResultsThe behavioral data showed statistically significant impairment in both recall of learned associations and generalization in schizophrenia and other psychosis groups compared to control subjects. Siblings did not differ significantly from controls in recall of learned associations but they showed impairments in generalization.ConclusionsImpairment in recall of learned associations and memory generalization seem to be present also in other psychotic disorders, not only in schizophrenia. Since decline in generalization was seen in addition in siblings the hypothesis that declarative memory could be one of endophenotypes of schizophrenia is supported by this study.
1638 – Prolonged Hospital Admissions Of Patients With Borderline Personality Disorder In The Context Of The New Legislation In England And Wales - Patients’ View
Authors: Clementi N. , Dobrzynska E. , Wiecko R. , Mehany S. , Fortugno F. , Eales M. , Barker D. , Rossiter S. , Britten S. 
Published: July 2013

IntroductionIn 2007 the Mental Health Act in England and Wales was amended and the definition of Mental Disorder was broadened. This change affected people with Personality Disorders who now can be admitted for hospital treatment without consent, often for prolonged period of time.ObjectivesThis poster reviews patients’ attitudes towards the new legislation and its consequences and also presents the research on the different perspectives about the new law.AimsTo review patients’ attitudes with regard to interfaces between Personality Disorders and the new law.MethodsUse of the specifically designed questionnaire for patients with Borderline Personality Disorders hospitalized under Mental Health Act. MEDLINE and PsycINFO databases were also searched for all English-language articles published between 2008 and 2012 containing the keywords “Personality Disorder”, “Mental Health Act” and “patients’ view on compulsory treatment”. Additional key articles published before 2008 were reviewed. The most relevant articles were selected for review.Results and conclusionsThere is still no common consensus in regard to the benefit of compulsory hospital admission of persons with Borderline Personality Disorders. Results from questionnaires are under review.
1647 – Affordability Of Alcoho And Alcohol Dependence Prevalence In Belarus
Authors: Razvodovsky Y.E. 
Published: July 2013

IntroductionSeveral studies evaluated the effects of changes in a price on various outcomes related to harmful alcohol consumption, including alcohol dependence, known to be specifically attributed to long-term alcohol abuse.ObjectivesAgainst this background, it would be interesting to evaluate the relationship between alcohol affordability and alcohol dependence prevalence rates in post-Soviet Belarus.MethodsTo examine the relation between alcohol affordability and alcohol dependence prevalence in Belarus between 1990 and 2010 regression analysis was performed using the statistical package “Statistica”.ResultsIn the period from 1990 to 2010 the prevalence of alcohol dependence in Belarus increased by 42,7% (from 1419,1 to 2024,4 per 10.000 of the population). The affordability of alcohol has increased significantly since the early 1990s: the average salary in 1993 could by 7.3 litres of vodka compared with 73.9 litres in 2010. The results of time series analysis suggest positive association between alcohol affordability and alcohol dependence prevalence rates: a 0.3% increase in the prevalence of alcohol dependence rate following a 1% increase in affordability of alcohol.ConclusionsThe results from this study are consistent with previous findings suggesting a significant association between alcohol affordability and alcohol-related problems. The main reason for the growth of alcohol consumption and alcohol-related problems in Belarus was the liberalization of the alcohol policy and increase in the affordability of alcohol. Hence, to prevent a further increase of alcohol affordability, increases alcohol prices seems to be one of the priority options of alcohol control policy in Belarus.
1649 – Possible Menstrual Psychosis: a Case Report
Authors: Puiu M.G. , Manea M. , Iordan A.M. , Manea M. , Patrichi B.E. , Frunza A.A. 
Published: July 2013

IntroductionDescribed since the 19th century, menstrual psychosis is considered a forgotten disorder. Current classification systems do not include the diagnosis of menstrual psychosis, a condition comprising in psychotic episodes recurring during each menstrual or premenstrual period, but remitting the rest of the month. The world literature consists mainly of case reports. To our knowledge this is the first Romanian report of menstrual psychosis.ObjectivesTo describe the course of the condition in a patient with multiple and rapid recurring psychotic episodes from onset until the most recent hospitalization.AimsTo better understand if this case could be considered a true menstrual psychosis.MethodsReview of the medical charts of the 57 hospitalizations the patient has had between 1977 and 2012 in the “Prof. Dr. Al. Obregia” Psychiatry Hospital.ResultsInitial diagnosis included discordant psychosis and atypical depressive state that shifted in time to schizoaffective disorder and various forms of schizophrenia. The history reveals cyclic episodes with short-term remissions and multiple hospitalizations. Treatment approaches also varied during the course of the disease, from ECT to second generation of antipsychotics without any consistent long-term remission. The frequency of episodes started to dramatically reduce only when the menopause installed.ConclusionPatients with a history of numerous admissions might benefit from a record review aimed at identifying temporal patterns. Clinicians should be aware of menstrual psychotic symptoms exacerbations in a minority of women with chronic mental disorders and therapeutic strategies need to be carefully considered and adjusted to each individual patient.