bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong convergence theorems for fixed point problems of infinite family of asymptotically quasi-ϕ-nonexpansive mappings and a system of equilibrium problems
Authors: Wang Xin , Hu Changsong , Guan Jinlin 
Published: August 2013

Abstract
In this paper, we introduce a general iterative algorithm for finding a common element of the set of common fixed points of infinite family of asymptotically quasi-ϕ-nonexpansive mappings and of the set of solutions for finite equilibrium problems in a real Banach space. Our results are the generalization of the results (Shehu in Comput. Math. Appl. 63:1089-1103, 2012; Kim in Fixed Point Theory Appl., 2011, doi:10.1186/1687-1812-2011-10) and (Kim and Buong in Fixed Point Theory Appl., 2011, doi:10.1155/2011/780764), and improvement of the result (Yang et al. in Appl. Math. Comput. 218:6072-6082, 2012).

MSC:47H09, 47H10, 47H17.
Kamenev-type oscillation criteria for higher-order nonlinear dynamic equations on time scales
Authors: Wu Xin , Sun Taixiang , Xi Hongjian , Chen Changhong 
Published: August 2013

Abstract
In this paper, we investigate the oscillation of the following higher-order dynamic equation:

{

r
n

(
t
)

[

(

r

n
−
1

(
t
)

(
⋯

(

r
1

(
t
)

x
△

(
t
)
)

△

⋯
)

△

)

△

]

γ

}

△

+
F

(
t
,
x

(
τ
(
t
)
)

)

=
0

on an arbitrary time scale T, where

n
≥
2

,

1

r
k

(
t
)

(

1
≤
k
≤
n

) are positive rd-continuous functions on T, and γ is the quotient of two odd positive integers,

τ
:
T
→
T

with

τ
(
t
)
>
t

and

F
∈
C
(
T
×
R
,
R
)

. We give sufficient conditions under which every solution of this equation is either oscillatory or tends to zero.

MSC:34K11, 39A10, 39A99.
The combination of arsenic, interferon-alpha, and zidovudine restores an “immunocompetent-like” cytokine expression profile in patients with adult T-cell leukemia lymphoma
Authors: Kchour Ghada , Rezaee SA Rahim , Farid Reza , Ghantous Akram , Rafatpanah Houshang , Tarhini Mahdi , Kooshyar Mohamad-Mehdi , El Hajj Hiba , Berry Fadwa , Mortada Mohamad , Nasser Roudaina , Shirdel Abbas , Dassouki Zeina , Ezzedine Mohamad , Rahimi Hossein , Ghavamzadeh Ardeshir , de Thé Hugues , Hermine Olivier , Mahmoudi Mahmoud , Bazarbachi Ali 
Published: August 2013

Abstract

Background
HTLV-I associated adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis due to chemo-resistance and immuno-compromised micro-environment. The combination of zidovudine and interferon-alpha (IFN) significantly improved survival in ATL. Promising results were reported by adding arsenic trioxide to zidovudine and IFN.

Results
Here we assessed Th1/Th2/Treg cytokine gene expression profiles in 16 ATL patients before and 30 days after treatment with arsenic/IFN/zidovudine, in comparison with HTLV-I healthy carriers and sero-negative blood donors. ATL patients at diagnosis displayed a Treg/Th2 cytokine profile with significantly elevated transcript levels of Foxp3, interleukin-10 (IL-10), and IL-4 and had a reduced Th1 profile evidenced by decreased transcript levels of interferon-γ (IFN-γ) and IL-2. Most patients (15/16) responded, with CD4+CD25+ cells significantly decreasing after therapy, paralleled by decreases in Foxp3 transcript. Importantly, arsenic/IFN/zidovudine therapy sharply diminished IL-10 transcript and serum levels concomittant with decrease in IL-4 and increases in IFN-γ and IL-2 mRNA, whether or not values were adjusted to the percentage of CD4+CD25+ cells. Finally, IL-10 transcript level negatively correlated with clinical response at Day 30.

Conclusions
The observed shift from a Treg/Th2 phenotype before treatment toward a Th1 phenotype after treatment with arsenic/IFN/zidovudine may play an important role in restoring an immuno-competent micro-environment, which enhances the eradication of ATL cells and the prevention of opportunistic infections.
Short–term effects of neoadjuvant chemoradiation therapy on anorectal function in rectal cancer patients: a pilot study
Authors: Kye Bong-Hyeon , Kim Hyung-Jin , Kim Jun-Gi , Kim Sung-Hwan , Shim Byoung-Yong , Lee Nan-Sook , Cho Hyeon-Min 
Published: August 2013

Abstract

Background
Neoadjuvant chemoradiation therapy followed by curative surgery has gained acceptance as the therapy of choice in locally advanced rectal cancer. However, deterioration of anorectal function after long-course neoadjuvant chemoradiation therapy combined with surgery for rectal cancer is poorly defined. The aim of this study was to evaluate the physiological and clinical change of anorectal function after neoadjuvant chemoradiation therapy for rectal cancer.

Methods
We analyzed 30 patients on whom preoperative anorectal manometry data were available both before and after chemoradiation from October 2010 to September 2011. All patients underwent long-course neoadjuvant chemoradiation therapy. We compared manometric parameters between before and after neoadjuvant chemoradiation therapy.

Results
Of 30 patients, 20 were males and 10 females. The mean age was 64.9 ± 9.9 years (range, 48-82). Before nCRT, the rectal compliance was higher in patients with ulceroinfiltrative type (P = 0.035) and greater involvement of luminal circumference (P = 0.017). However, there was the tendency of increased rectal sensory threshold for desire to defecate when the patient had decreased circumferential ratio of the tumor (P = 0.099), down-graded T stage (P = 0.016), or reduced tumor volume (P = 0.063) after neoadjuvant chemoradiation.

Conclusions
Neoadjuvant chemoradiation therapy did not significantly impair overall sphincter function before radical operation. The relationship between tumor response of chemoradiation and sensory threshold for desire to defecate may suggest that neoadjuvant chemoradiation may be helpful for defecatory function as well as local disease control, at least in the short-term period after the radiation in locally advanced rectal cancer patients.
Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder
Authors: Yang Ruoting , Daigle Jr Bernie J , Muhie Seid Y , Hammamieh Rasha , Jett Marti , Petzold Linda , Doyle Francis J 
Published: August 2013

AbstractBackgroundPost-traumatic stress disorder (PTSD) is a severe anxiety disorder that affects a substantial portion of combat veterans and poses serious consequences to long-term health. Consequently, the identification of diagnostic and prognostic blood biomarkers for PTSD is of great interest. Previously, we assessed genome-wide gene expression of seven brain regions and whole blood in a social defeat mouse model subjected to various stress conditions.ResultsTo extract biological insights from these data, we have applied a new computational framework for identifying gene modules that are activated in common across blood and various brain regions. Our results, in the form of modular gene networks that highlight spatial and temporal biological functions, provide a systems-level molecular description of response to social stress. Specifically, the common modules discovered between the brain and blood emphasizes molecular transporters in the blood-brain barrier, and the associated genes have significant overlaps with known blood signatures for PTSD, major depression, and bipolar disease. Similarly, the common modules specific to the brain highlight the components of the social defeat stress response (e.g., fear conditioning pathways) in each brain sub-region.ConclusionsMany of the brain-specific genes discovered are consistent with previous independent studies of PTSD or other mental illnesses. The results from this study further our understanding of the mechanism of stress response and contribute to a growing list of diagnostic biomarkers for PTSD.
Systemic sclerosis sera affect fibrillin-1 deposition by dermal blood microvascular endothelial cells: therapeutic implications of cyclophosphamide
Authors: Villano Marilisa , Borghini Annalisa , Manetti Mirko , Gabbrielli Erica , Rossi Antonella , Sestini Piersante , Milia Anna Franca , Nacci Francesca , Guiducci Serena , Matucci-Cerinic Marco , Ibba-Manneschi Lidia , Weber Elisabetta 
Published: August 2013

Abstract
Introduction
Systemic sclerosis (SSc) is a connective tissue disorder characterized by endothelial cell injury, autoimmunity and fibrosis. The following three fibrillin-1 alterations have been reported in SSc. (1) Fibrillin-1 microfibrils are disorganized in SSc dermis. (2) Fibrillin-1 microfibrils produced by SSc fibroblasts are unstable. (3) Mutations in the FBN1 gene and anti-fibrillin-1 autoantibodies have been reported in SSc. Fibrillin-1 microfibrils, which are abundantly produced by blood and lymphatic microvascular endothelial cells (B-MVECs and Ly-MVECs, respectively), sequester in the extracellular matrix the latent form of the potent profibrotic cytokine transforming growth factor β (TGF-β). In the present study, we evaluated the effects of SSc sera on the deposition of fibrillin-1 and microfibril-associated glycoprotein 1 (MAGP-1) and the expression of focal adhesion molecules by dermal B-MVECs and Ly-MVECs.

Methods
Dermal B-MVECs and Ly-MVECs were challenged with sera from SSc patients who were treatment-naïve or under cyclophosphamide (CYC) treatment and with sera from healthy controls. Fibrillin-1/MAGP-1 synthesis and deposition and the expression of αvβ3 integrin/phosphorylated focal adhesion kinase and vinculin/actin were evaluated by immunofluorescence and quantified by morphometric analysis.

Results
Fibrillin-1 and MAGP-1 colocalized in all experimental conditions, forming a honeycomb pattern in B-MVECs and a dense mesh of short segments in Ly-MVECs. In B-MVECs, fibrillin-1/MAGP-1 production and αvβ3 integrin expression significantly decreased upon challenge with sera from naïve SSc patients compared with healthy controls. Upon challenge of B-MVECs with sera from CYC-treated SSc patients, fibrillin-1/MAGP-1 and αvβ3 integrin levels were comparable to those of cells treated with healthy sera. Ly-MVECs challenged with SSc sera did not differ from those treated with healthy control sera in the expression of any of the molecules assayed.

Conclusions
Because of the critical role of fibrillin-1 in sequestering the latent form of TGF-β in the extracellular matrix, its decreased deposition by B-MVECs challenged with SSc sera might contribute to dermal fibrosis. In SSc, CYC treatment might limit fibrosis through the maintenance of physiologic fibrillin-1 synthesis and deposition by B-MVECs.
Rituximab Maintenance Compared With Observation After Brief First-Line R-FND Chemoimmunotherapy With Rituximab Consolidation in Patients Age Older Than 60 Years With Advanced Follicular Lymphoma: A Phase III Randomized Study by the Fondazione Italiana Linfomi
Authors: Vitolo Umberto , Ladetto Marco , Boccomini Carola , Baldini Luca , De Angelis Federico , Tucci Alessandra , Botto Barbara , Chiappella Annalisa , Chiarenza Annalisa , Pinto Antonello , De Renzo Amalia , Zaja Francesco , Castellino Claudia , Bari Alessia , Alvarez De Celis Isabel , Evangelista Andrea , Parvis Guido , Gamba Enrica , Lobetti-Bodoni Chiara , Ciccone Giovannino , Rossi Giuseppe 
Published: August 2013

Purpose To evaluate the efficacy of rituximab maintenance in 60- to 75-year-old patients with advanced follicular lymphoma responding to brief first-line chemoimmunotherapy followed by rituximab consolidation. Patients and Methods A total of 234 treatment-naive 60- to 75-year-old patients began chemoimmunotherapy with four monthly courses of rituximab, fludarabine, mitoxantrone, and dexamethasone (R-FND) followed by four weekly cycles of rituximab consolidation. Of these, 210 patients completed the planned treatment, and 202 responders were randomly assigned to rituximab maintenance (arm A) for 8 months, once every 2 months for a total of four doses, or to observation (arm B). Results Median ages in arms A and B were 66 and 65 years, respectively. After induction and consolidation therapy, the overall response rate was 86%, with 69% complete remissions (CR). After a 42-month median follow-up from diagnosis, 3-year progression-free survival (PFS; the primary end point) and overall survival (OS) were 66% (95% CI, 59% to 72%) and 89% (95% CI, 85% to 93%), respectively. After randomization, 2-year PFS was 81% for rituximab maintenance versus 69% for observation, with a hazard ratio of 0.74 (95% CI, 0.45 to 1.21; P = .226), although this was not statistically significant. No differences between the two arms were detected for OS. Overall, the regimen was well-tolerated. The most frequent grade 3 to 4 toxicity was neutropenia (25% of treatment courses), with 13 infections. Two toxic deaths (0.8%) occurred during induction treatment. Conclusion A brief R-FND induction plus rituximab consolidation achieved excellent results with high CR and PFS rates, supporting the feasibility of this regimen in patients older than 60 years. A short rituximab maintenance did not achieve a statistically significant PFS improvement over observation.
Vertebral Compression Fracture After Spine Stereotactic Body Radiotherapy: A Multi-Institutional Analysis With a Focus on Radiation Dose and the Spinal Instability Neoplastic Score
Authors: Sahgal Arjun , Atenafu Eshetu G. , Chao Sam , Al-Omair Ameen , Boehling Nicholas , Balagamwala Ehsan H. , Cunha Marcelo , Thibault Isabelle , Angelov Lilyana , Brown Paul , Suh John , Rhines Laurence D. , Fehlings Michael G. , Chang Eric 
Published: August 2013

Purpose Vertebral compression fracture (VCF) is increasingly recognized as an adverse event after spine stereotactic body radiotherapy (SBRT). We report a multi-institutional study aimed at clarifying the risk and predictive factors associated with VCF. Patients and Methods A total of 252 patients with 410 spinal segments treated with SBRT were included. The primary outcome was the development of VCF (a new VCF or progression of a baseline VCF). In addition to various patient-, treatment-, and tumor-specific factors, the Spinal Instability Neoplastic Scoring (SINS) system was applied to determine predictive value. Results The median follow-up was 11.5 months (range, 0.03 to 113 months). The median and mean overall survival rates were 16 and 26 months, respectively. We observed 57 fractures (57 of 410, 14%), with 47% (27 of 57) new fractures and 53% (30 of 57) fracture progression. The median time to VCF was 2.46 months (range, 0.03 to 43.01 months), and 65% occurred within the first 4 months. The 1- and 2-year cumulative incidences of fracture were 12.35% and 13.49%, respectively. Multivariable analysis identified dose per fraction (greatest risk for ≥ 24 Gy v 20 to 23 Gy v ≤ 19 Gy), in addition to three of the six original SINS criteria: baseline VCF, lytic tumor, and spinal deformity, as significant predictors of VCF. Conclusion Caution must be observed when treating with ≥ 20 Gy/fraction, in particular, for patients with lytic tumor, spinal misalignment, and a baseline VCF. Frequent short-term follow-up is required, as nearly two thirds of all VCF occurred within the first 4 months. We also conclude that SINS may have utility in predicting patients at high risk of SBRT-induced VCF.
Swimming by medusae Sarsia tubulosa in the viscous vortex ring limit
Authors: Katija Kakani , Jiang Houshuo 
Published: August 2013

Lay AbstractAs organisms swim in their natural environment, they are constantly striving to successfully forage, escape from predation, and search for mates to reproduce. At some stage in their life cycle, most organisms in the ocean have operated in environments where the Reynolds number (Re) is small and have developed strategies and behaviors to overcome the effects of viscosity. Relatively little is known about these animal‐fluid interactions at relatively small (Re > 1), viscous size scales. We combine high‐speed kinematic and velocity field measurements of 1‐mm velar‐diameter, jet‐propelled medusae, Sarsia tubulosa, and apply rigorous criteria to identify an analytical model that best describes the hydrodynamic signals created during swimming. We found that the hydrodynamic signature of a jet‐propelled medusa at relatively small size scales is best described by an impulsive Stokeslet, which has important ecological implications for the ambush‐feeding predator.
Fecal transplantation does not transfer either susceptibility or resistance to food borne listeriosis in C57BL/6 and BALB/c/By mice
Authors: Myers-Morales Tanya , Bussell Kate M , D'Orazio Sarah EF 
Published: August 2013

The composition of the intestinal microbiota has wide reaching effects on the health of an individual, including the development of protective innate immune responses. In this report, a fecal transplantation approach was used to determine whether resistance to food borne listeriosis was dependent on the murine gut microbiota. Transplantation of BALB/c/By feces did not increase the susceptibility of C57BL/6 mice toListeria monocytogenesinfection. Likewise, transplantation of C57BL/6 fecal matter did not enhance the resistance of BALB/c/By mice. Thus, intestinal microbiota composition is not a key factor that confers either susceptibility or resistance to food borne listeriosis in mice.
Diagnosing Diabetes Mellitus: Performance of Hemoglobin A1c Point-of-Care Instruments in General Practice Offices
Authors: Sølvik Una Ørvim , Røraas Thomas , Christensen Nina Gade , Sandberg Sverre 
Published: August 2013

BACKGROUND
Hemoglobin A1c (Hb A1c) measurement by hospital laboratory instruments, but not by point-of-care (POC) instruments, has been recommended for use to diagnose diabetes mellitus. We evaluated results from 13 Hb A1c external quality assurance (EQA) surveys over a 6-year period in Norway, from both POC instruments used in general practice (GP) offices and instruments in hospital laboratories, against the analytical quality specifications recommended for use of Hb A1c to diagnose diabetes mellitus.

METHODS
All GP offices (n = 1288) and hospital laboratories (n = 52) measuring Hb A1c in Norway participated in the EQA survey. The percentage of participants that performed measurements within the quality specifications was calculated. Pooled within-laboratory CVs were estimated for the Afinion, DCA 2000, DCA 2000+, DCA VantageTM, and Nycocard Hb A1c Reader instruments and for hospital laboratory instruments.

RESULTS
Between 60% to 90% of Afinion and DCA users and hospital laboratories performed Hb A1c measurements within the quality specifications for both trueness (6.0%) and imprecision (CV ≤2.0%) at 2 levels in each EQA survey. The pooled within-laboratory CVs for the Afinion and DCA instruments and hospital laboratories were below the recommended limit of 2.0% for most of the surveys.

CONCLUSIONS
A large proportion of GP offices using Afinion and DCA POC instruments to measure Hb A1c fulfill the analytical quality specifications for diagnosing diabetes mellitus, and these instruments demonstrate analytical quality comparable to that of hospital laboratory instruments. When GP offices participate in a stringent quality assurance program and generate Hb A1c measurements that meet analytical quality specifications, these measurements can be recommended for use to diagnose diabetes mellitus.
„… da Mittel zur Anschaffung von Büchern überhaupt nicht zur Verfügung stehen.“
Authors: Butte Sandra , Wiederkehr Stefan 
Published: August 2013

Zusammenfassung
Die Berliner Akademiebibliothek führt seit 2012 systematische Recherchen nach NS-Raubgut in ihren Beständen durch. Der Beitrag gibt einen Überblick über die Projektziele und vorläufige Ergebnisse. In der Akademiebibliothek, deren Bestände u. a. aufgrund fehlender Erwerbungsmittel bis 1945 nur langsam, ab 1950 aber sehr schnell anwuchsen, überwiegt „sekundäres Raubgut“. Bei 2.079 Zugängen bis zum Erwerbungsjahr 1956 besteht ein Raubgutverdacht im engeren Sinne.
Die Vermittlung von Recherchekompetenzen in Online-Tutorials
Authors: Schröder Nadine 
Published: August 2013

Zusammenfassung
Der vorliegende Beitrag
Bei dem vorliegendem Text handelt es sich in wesentlichen Teilen um eine überarbeitete und gekürzte Fassung der Bachelorarbeit der Verfasserin, die diese im Sommersemester 2011 an der Fachhochschule Köln vorgelegt hat. Schröder, Nadine: Die Vermittlung von Recherchekompetenzen in Online-Tutorials. 2011. http://www.fbi.fh-koeln.de/institut/papers/kabi/volltexte/band060.pdf (22.02.2013).
beschäftigt sich mit Recherchekompetenzen von Studierenden und der Vermittlung der betreffenden Kenntnisse und Fähigkeiten in Online-Tutorials als einer Methode der Vermittlung von Informationskompetenz. Eine Analyse ausgewählter bibliothekarischer Online-Tutorials untersucht, inwieweit die Inhalte in Bezug auf die Informationsbedürfnisse der Studierenden berücksichtigt und didaktisch aufbereitet werden.
Aktuelle Entwicklungen an den österreichischen Bibliotheken 2012Der folgende Beitrag bietet einen Überblick über Projekte und Initiativen, die 2012 das österreichische Bibliothekswesen geprägt haben. Der Autor ist Leiter der Universitätsbibliothek der Medizinischen Universität Wien, der größten medizinischen Fachbibliothek in Österreich, Vorsitzender des Forums Universitätsbibliotheken Österreichs (ubifo) und Mitglied der AG Strategische Planung im Österreichischen Bibliothekenverbund, des Open Access Netzwerk Österreich (OANA), des Fachnormenausschusses Bibliotheks-, Archiv-, Dokumentations- Informationswesen und optische Speichersysteme (FNA 069 BADOS), von Bibliotheken Archive Museen (BAM) Österreich sowie des Präsidiums der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare (VÖB).
Authors: Bauer Bruno 
Published: August 2013

Zusammenfassung
Im vorliegenden Beitrag wird über aktuelle Probleme und Trends im österreichischen Bibliothekswesen im Jahr 2012 berichtet. Vorgestellt werden Verbundaktivitäten und Kooperationsprojekte österreichischer Bibliotheken, aktuelle Projekte der Österreichischen Nationalbibliothek und des Forums Universitätsbibliotheken Österreichs. Angesprochen werden auch Themen wie Open Access, NS-Provenienzforschung, Ausbildung im Bibliotheks-, Dokumentations- und Informationswesen, Tagungen und Publikationen der Bibliotheksverbände sowie Bibliotheks- und Informationspolitik in Österreich.
Finite time blow-up for semilinear wave equations with variable coefficients
Authors: Han Wei 
Published: August 2013

Abstract
This paper is devoted to studying initial value problems for
semilinear wave equations with variable coefficients with subcritical
exponents for n (n ≥ 1) space dimensions. We prove that
solutions to a certain kind of subcritical wave equations cannot be
global if the initial values are positive somewhere and nonnegative
no matter how small the initial data are, and also we give the sharp
lifespan estimate of solutions for the problems. This solves a part
of the famous Strauss' conjecture about semilinear wave equations in
the case of subcritical exponents and variable coefficients Cauchy
problems.