bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Russian Presidential Discourse on the example of Putin's inaugural speeches: results of quantitative content analysis
Authors: Voronin Vsevolod Alekseevich , Voronov Aleksei Vital'evich 
Published: July 2024

This article examines V. V. Putin's discourse from the point of view of its semantic content – the values voiced by the president, a view on the further development of the country, setting goals, etc. The object of the study is the inaugural speeches of the President of Russia, and the subject is the narrative aspect of these speeches. The article hypothesizes that the semantic accents in the inaugural speeches of the head of state changed in accordance with the domestic and foreign policy situation and in later speeches became more focused on foreign policy problems, as well as had a more conservative orientation. The purpose of the work is to identify changes in the narrative aspect of Vladimir Putin's inaugural speeches and evaluate them in the context of changes in the political situation in the country and the world. During the research, methods such as quantitative content analysis (performed separately for each text), comparative analysis, and graphical modeling were used. The authors concluded that over time, the presidential discourse considered on the example of inaugural speeches has undergone significant semantic changes. The share of values characteristic of conservative ideology has become higher in later speeches. At the same time, the presence of liberal democratic narratives in recent speeches has been minimal. The President's speeches have become more focused on global foreign policy issues, as well as security issues. The authors associate these changes with changes in the country's foreign and domestic policy. In the 2000s, it is necessary to build a free democratic society, as well as solve the problems of poverty and terrorism. However, after overcoming these problems, the state and the president are faced with the tasks of maintaining living standards, maintaining power and opposing Western countries. All this was reflected in V. V. Putin's rhetoric.
Growth Dynamics and Export Potential of India's Poultry Sector: A Comprehensive Analysis
Authors: Kuppan Mohanakrishnan , Ravichandran S. , Venkataraman R. , Pouchepparadjou A. , Ramesh S. 
Published: July 2024

India ranks as the third largest egg producer and fifth largest producer of poultry meat globally. Commercial poultry farms accounts about eighty-five percent of countries' egg production, the remaining comes from household/backyard poultry. Poultry production plays a significant part in the socio-economic life of India's rural population. This research focused on growth trends, instability in egg and poultry meat production and export trend, instability and Markov chain model was used to identify the market share of importing countries and stable importers of Indian poultry products. The state wise analysis revealed that the Uttar Pradesh registered highest growth rate among the top ten egg producing states for the study period. The export of poultry products has positive growth. Oman and Maldives are reliable market partners for India’s poultry product over the period.
Total Synthesis of Tubulysin U and Its C‐4 Epimer
Authors: Yang Xiu‐dong , Dong Chang‐ming , Chen Jian , Ding Ya‐hui , Liu Qi , Ma Xiao‐yan , Zhang Quan , Chen Yue 
Published: April 2013

AbstractThe Tup fragments of tubulysins were synthesized with a tandem reaction as the key step, and unexpected diastereoselectivity was observed in the first Grignard addition stage. The coupling of the enolate of a thiazolyl ketone with chiral sulfinimines furnished the backbone of the Tuv fragment with over 100:1 d.r. and high yield. Thus, tubulysin U and C‐4 epi‐tubulysin U were prepared in a highly selective and efficient manner. The results of the MTT assay furthermore indicated that C‐4 epi‐tubulysin U maintained significant growth inhibition activities against several cancer cell lines.
L2‐Gain Analysis for Synchronization of Stochastic Complex Network with Switched Topology and Time‐Varying Delay
Authors: Li Hui , Zhang Chun‐Xi , Lin Zhi‐Li 
Published: April 2013

AbstractWe investigate the exponential stability and L2‐gain analysis for the synchronization of stochastic complex networks under average dwell time switched topology with consideration of external disturbance, internal noise and fast time‐varying delay in the synchronized process. Based on the proposed stochastic network, a new L2‐gain synchronization is proposed to solve the mean‐square exponential stable under switched topology with an H∞ performance from the extrinsic disturbances to the synchronization error. The obtained results are applicable for the fast time‐varying case with larger‐than‐1 delay derivative. Finally, numerical simulations are performed to demonstrate the effectiveness of our strategies.
General Stability of Stochastic Markov Jump Linear Systems Based on the Spectrum Technique
Authors: Sheng Li , Gao Ming , Zhang Weihai 
Published: April 2013

AbstractThis paper applies the spectrum technique to investigate the general stability of stochastic Markov jump linear systems (SMJLSs). First, the notion of spectrum for SMJLSs is defined and the relationship between the spectrum and the asymptotical mean square stability is revealed. Second, by analyzing the spectrum distribution in the complex plane, some new concepts of stability, such as critical stability, regional stability, and essential instability, are introduced for SMJLSs. Necessary and sufficient conditions on such general stability are established. Finally, several numerical examples are carried out to illustrate the developed theory.
If microbial ecosystem therapy can change your life, what's the problem?
Authors: Ettinger Grace , Burton Jeremy P. , Reid Gregor 
Published: April 2013

AbstractThe increased incidence of morbidity and mortality due to Clostridium difficile infection, had led to the emergence of fecal microbial transplantation (FMT) as a highly successful treatment. From this, a 32 strain stool substitute has been derived, and successfully tested in a pilot human study. These approaches could revolutionize not only medical care of infectious diseases, but potentially many other conditions linked to the human microbiome. But a second revolution may be needed in order for regulatory agencies, society and medical practitioners to accept and utilize these interventions, monitor their long term effects, have a degree of control over their use, or at a minimum provide guidelines for donors and recipients.
Kein Grün ohne Umbau der Proteinimport‐Maschinerie
Authors: Krupinska Karin 
Published: April 2013

AbstractChloroplasten sind die bekanntesten Vertreter der Plastiden, den charakteristischen Organellen der Pflanzenzelle. Chloroplasten findet man in den grünen Geweben der Pflanzen, und Wachstum und Produktivität von Pflanzen hängt von der Photosynthese in den Chloroplasten ab. Aktuelle Forschungsergebnisse zeigen, dass die für den Import von Photosynthese‐Proteinen verantwortlichen ”Türsteher“ in der Hüllmembran der Plastiden während des Ergrünens deutlich umstrukturiert werden müssen.
Eine Frage des Geschmackes
Authors: Kronberg Inge 
Published: April 2013

Abstract“Aroma” oder “gusto” heißt es auf Spanisch, “flavor” oder “taste” auf Englisch – im Deutschen sprechen wir einfach vom “Geschmack”, ohne uns genau festzulegen, ob wir von der Geschmacksqualität eines Nahrungsmittels oder vom Geschmacksempfinden des Genießers sprechen. Die Geschmacksqualität hängt von molekularen Bestandteilen des Nahrungsstoffes ab, das Geschmacksempfinden von der neuronalen Verarbeitung und subjektiven Wahrnehmung. Geschmacksrezeptoren gibt es nicht nur auf der Zunge, sie sind auch in anderen Körperbereichen für die Signalvermittlung zwischen Zelläußerem und Zellinnerem zuständig.
Front‐Loading Natural‐Product‐Screening Libraries for log P: Background, Development, and Implementation
Authors: Camp David , Campitelli Marc , Carroll Anthony R. , Davis Rohan A. , Quinn Ronald J. 
Published: April 2013

AbstractIn the period from January 1981 to December 2010, 1068 small‐molecule new chemical entities (NCEs) were introduced, of which ca. 34% are either a natural product or a close analogue. While this metric reflects the impact natural products have played in delivering new chemical starting points (leads) for the pharmaceutical industry, it does not capture the decline this approach has suffered over the last 20 years as the high‐throughput screening (HTS) of pure compound libraries has become more popular. An impediment to natural‐product drug discovery in the HTS paradigm is the lack of a clear strategy that enables front‐loading of an extract or fraction's chemical constituents so that they are compliant with lead‐ and drug‐like chemical space. To address this imbalance, an approach based on lipophilicity, as measured by clog P has been developed that, together with advances being made in isolation and structural elucidation, can afford natural product leads in timelines compatible with pure compound screening.
Comprehensive Analysis of Fragment Orbital Interactions to Build Highly π‐Conjugated Thienylene‐Substituted Phenylene Oligomers
Authors: Florès Jean‐Charles , Lacour Marie‐Agnès , Sallenave Xavier , Serein‐Spirau Françoise , Lère‐Porte Jean‐Pierre , Moreau Joël J. E. , Miqueu Karinne , Sotiropoulos Jean‐Marc , Flot David 
Published: April 2013

Abstractπ‐Conjugated thienylenephenylene oligomers with fluorinated and dialkoxylated phenylene fragments have been designed and prepared to understand the interactions in fragment orbitals, the influence of the substituents (F, OMe) on the HOMO–LUMO gap, and the role of intramolecular non‐covalent cumulative interactions in the construction of π‐conjugated nanostructures. Their strong conjugation was also evidenced in the gas phase by UV photoelectron spectroscopy and theoretical calculations. These results can be explained by the crucial role of the relative energetic positions of the π orbitals of the dimethoxyphenylene, which was used to model the dialkoxyphenylene entity, in determining the π/π*orbital levels of the fluorinated phenylene entity. Dialkoxyphenylenes raise the HOMO orbitals, whereas fluorinated phenylenes lower the LUMO orbitals in the oligomers. In addition, the presence of S⋅⋅⋅F and H⋅⋅⋅F interactions in the fluorinated phenylenethienylene compounds add to the S⋅⋅⋅O interactions in the mixed targets and contribute to the full conjugation in the oligomer, inducing weak inter‐ring angles between the involved aromatic cycles. These results, which showed extended conjugation of the π system, were corroborated by a narrow HOMO–LUMO gap (according to DFT calculations) and by a relatively strong maximum wavelength (as obtained by TD‐DFT calculations and experimental UV/Vis measurements). The crystallographic data of two mixed thienylene(fluorinated and dialkoxylated phenylene) five‐ring oligomers agree with the above results and show the formation of quasi‐planar conformations with non‐covalent S⋅⋅⋅O, H⋅⋅⋅F, and S⋅⋅⋅F interactions. These studies in the solid and gas phases show the relevance of associating dialkoxyphenylene and fluorinated phenylene fragments with thiophene to lead to oligomers with improved electronic delocalization for electronic or optoelectronic devices.
Receipt of National Comprehensive Cancer Network guideline‐concordant prostate cancer care among African American and Caucasian American men in North Carolina
Authors: Ellis Shellie D. , Blackard Bonny , Carpenter William R. , Mishel Merle , Chen Ronald C. , Godley Paul A. , Mohler James L. , Bensen Jeannette T. 
Published: April 2013

BACKGROUNDAfrican Americans have a higher incidence of prostate cancer and experience poorer outcomes compared with Caucasian Americans. Racial differences in care are well documented; however, few studies have characterized patients based on their prostate cancer risk category, which is required to differentiate appropriate from inappropriate guideline application.METHODSThe medical records of a population‐based sample of 777 North Carolina men with newly diagnosed prostate cancer were studied to assess the association among patient race, clinical factors, and National Comprehensive Cancer Network (NCCN) guideline‐concordant prostate cancer care.RESULTSAfrican Americans presented with significantly higher Gleason scores (P = .025) and prostate‐specific antigen levels (P = .008) than did Caucasian Americans. However, when clinical T stage was considered as well, difference in overall risk category only approached statistical significance (P = .055). Across risk categories, African Americans were less likely to have surgery (58.1% versus 68.0%, P = .004) and more likely to have radiation (39.0% versus 27.4%, P = .001) compared with Caucasian Americans. However, 83.5% of men received guideline‐concordant care within 1 year of diagnosis, which did not differ by race in multivariable analysis (odds ratio = 0.83; 95% confidence interval  = 0.54‐1.25). Greater patient‐perceived access to care was associated with greater odds of receiving guideline‐concordant care (odds ratio = 1.06; 95% confidence interval = 1.01‐1.12).CONCLUSIONSAfter controlling for NCCN risk category, there were no racial differences in receipt of guideline‐concordant care. Efforts to improve prostate cancer treatment outcomes should focus on improving access to the health care system. Cancer 2013;2282–2290. © 2013 American Cancer Society.
The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk
Authors: Angstadt Andrea Y. , Berg Arthur , Zhu Junjia , Miller Paige , Hartman Terryl J. , Lesko Samuel M. , Muscat Joshua E. , Lazarus Philip , Gallagher Carla J. 
Published: April 2013

BACKGROUNDGenetic polymorphisms in combination with the Western‐style diet, physical inactivity, smoking, excessive alcohol consumption, and obesity have been hypothesized to affect colorectal cancer (CRC) risk. Metabolizers of environmental carcinogenic and endogenous compounds affecting CRC risk include the phase II detoxification UDP‐glucuronosyltransferase (UGT) enzymes UGT2B17 and UGT2B28, which are 2 of the most commonly deleted genes in the genome.METHODSTo study the effect of UGT2B17 and UGT2B28 copy number variation (CNV) on CRC risk, 665 Caucasian CRC cases and 621 Caucasian controls were genotyped who had completed extensive demographics and lifestyle questionnaires.RESULTSA significant association between the UGT2B17 deletion genotype (0/0) and decreased CRC risk was found when the entire population was analyzed (P = .044). Stratification by sex yielded a decreased risk (P = .020) in men with the UGT2B17 deletion (0/0), but no association was observed in women (P = .724). A significant association between UGT2B17 (0/0) and decreased risk for rectal (P = .0065) but not colon cancer was found. No significant association was found between UGT2B28 CNV and CRC risk.CONCLUSIONSThe UGT2B17 deletion genotype (0/0) was associated with a decreased CRC risk in a Caucasian population. After sex stratification, the association was observed in men but not in women, which is consistent with previous findings that men have higher UGT2B17 expression and activity than women. Because UGT2B17 metabolizes certain nonsteroidal anti‐inflammatory drugs and flavonoids with antioxidative properties, individuals with a gene deletion may have higher levels of these protective dietary components. Cancer 2013;119:2477‐2485. © 2013 American Cancer Society.
Cumulative family risk predicts sibling adjustment to childhood cancer
Authors: Long Kristin A. , Marsland Anna L. , Alderfer Melissa A. 
Published: April 2013

BACKGROUNDProlonged, intensive treatment regimens often disrupt families of children with cancer. Siblings are at increased risk for distress, but factors underlying this risk have received limited empirical attention. In this study, the authors examined associations between the family context and sibling distress.METHODSSiblings of children with cancer (ages 8‐18 years; N = 209) and parents (186 mothers and 70 fathers) completed measures of sibling distress, family functioning, parenting, and parent post‐traumatic stress. Associations between sibling distress and each family risk factor were evaluated. Then, family risks were considered simultaneously by calculating cumulative family risk index scores.RESULTSAfter controlling for sociodemographic covariates, greater sibling distress was associated with more sibling‐reported problems with family functioning and parental psychological control, lower sibling‐reported maternal acceptance, and lower paternal self‐reported acceptance. When risk factors were considered together, the results supported a quadratic model in which associations between family risk and sibling distress were stronger at higher levels of risk.CONCLUSIONSThe current findings support a contextual model of sibling adjustment to childhood cancer in which elevated distress is predicted by family risk factors, both alone and in combination. Cancer 2013;119:2503‐2510. © 2013 American Cancer Society.
Biochemical and structural characterization of non‐glycosylated Yarrowia lipolytica LIP2 lipase
Authors: Aloulou Ahmed , Bénarouche Anaïs , Puccinelli Delphine , Spinelli Silvia , Cavalier Jean‐François , Cambillau Christian , Carrière Frédéric 
Published: April 2013

AbstractThe LIP2 lipase from the yeast Yarrowia lipolytica (YLLIP2) is assumed to be a good drug candidate for enzyme replacement therapy in patients with pancreatic exocrine insufficiency. Understanding and improving its biochemical properties are essential for its oral administration. YLLIP2 is a highly glycosylated protein, with glycan chains accounting for about 13% of the molecular mass of the native protein. Two potential N‐glycosylation sites (N113IS and N134NT) can be identified from YLLIP2 amino acid sequence. YLLIP2 mutants with single (N113Q or N134Q) or combined (N113Q/N134Q) substitutions of these glycosylation sites were expressed in the yeast Pichia pastoris, purified and characterized. Lipase specific activity and adsorption at the lipid–water interface were found to be decreased in the absence of N‐glycosylation. It was thus shown that the glycosylated enzyme had a better ability to bind and penetrate a DLPC monolayer than the non‐glycosylated N113Q/N134Q mutant. Comparison of wild‐type glycosylated and non‐glycosylated YLLIP2 shows that the N‐glycosylation clearly contributes to the high stability of YLLIP2 in the presence of pepsin in vitro, and to a lower extent in the presence of chymotrypsin. The X‐ray structure of the YLLIP2 N113Q/N134Q double mutant was obtained at 2.6 Å resolution and was found to be identical to that of wild‐type YLLIP2, with the lid in a closed conformation. Glycosylation is therefore not essential for a proper folding of YLLIP2.Practical applications: The LIP2 lipase from the yeast Yarrowia lipolytica is one of the most active lipases identified so far. Among the various applications envisioned for this enzyme, it seems particularly well adapted for enzyme replacement therapy in patients with pancreatic exocrine insufficiency. It is active and stable at low pH values, resistant to bile salts, and its glycosylation allows a high resistance to pepsin. All these properties are important for developing the oral administration of digestive enzymes used as drugs.
Inpatients with Severe Anorexia Nervosa and Their Siblings: Non‐shared Experiences and Family Functioning
Authors: Dimitropoulos Gina , Freeman Victoria E. , Bellai Kaitlin , Olmsted Marion 
Published: April 2013

AbstractObjectivesThe aims of this study were the following: to identify perceptions of patients with anorexia nervosa (AN) and their siblings regarding differential experiences within and external to the family including sibling interactions, parental treatment, relationships with peers and events that are unique to each sibling; (2) to compare how patients and their siblings perceive eating disorder symptoms, parental affection/control, social support and stigma; and (3) to test associations with family functioning for patients with AN and their siblings.MethodA total of 26 patients paired with their siblings were recruited from an Eating Disorder Program and administered standardized instruments measuring different experiences within and external to the family, the impact of eating disorder behaviours, stigma, social support and family functioning.ResultsPatients rated high on the differential experience of jealousy in contrast to their siblings. Patients scored higher than their siblings on eating symptoms, whereas siblings scored higher on social support. The impact of AN on the family, stigma towards the individual and family, and social support accounted for 37% of the variance in family functioning from the sibling perspective after controlling for age and gender. Of these variables, impact of AN on the family made the largest contribution.DiscussionFamily‐based and sibling‐based interventions that aim to reduce the effects of the illness on the sibling relationship and the family are recommended. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
Synthesis, Characterization of Novel Bisheteroaryl Bisazo Dyes, and Their Dyeing and Solvatochromic Behavior
Authors: Modi Visha P. , Patel Hasmukh S. 
Published: April 2013

ABSTRACT4‐Phenyl‐2‐aminothaizole was diazotized and coupled with N‐(alkyl)‐2‐oxo‐3‐cyano‐4‐methyl‐6‐hydroxypyridine (2‐pyridone). The resultant dyes were named as N‐(alkyl)‐6‐hydroxy‐4‐methyl‐2‐oxo‐5‐((4‐phenylthiazole‐2‐yl)diazenyl)‐1,2‐dihydro pyridine‐3‐carbonitrite and duly characterized. The diazotized aryl amines were then coupled to a moiety of above‐mentioned dyes at 5‐position of thiazole. The obtained bisheteroaryl azo dyes were characterized by elemental analysis and spectral studies. Solvent effects on the visible absorption spectra of the dyes were evaluated. The color of the dyes is discussed with respect to the nature of the heterocyclic ring, aromatic amines, and substituents present therein. All these dyes were applied as disperse dyes on to polyester fabrics, and their fastness properties were evaluated. © 2013 Wiley Periodicals, Inc. Heteroatom Chem 24:208–220, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21085