bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultraviolet A1 phototherapy beyond morphea: experience in 83 patients
Authors: Connolly Karen L. , Griffith James L. , McEvoy Marian , Lim Henry W. 
Published: June 2015

SummaryBackground/PurposeUltraviolet A1 (UVA1) phototherapy has been used for over 15 years in the United States, primarily for the treatment of localized sclerosis and various sclerosing disorders. The objective was to describe use of UVA1 for dermatoses beyond localized sclerosis at two academic institutions.MethodsData from 83 patients treated with low‐ (20–40 J/cm2), medium‐ (>40–80 J/cm2), and high‐ (>80–120 J/cm2) dose UVA1 phototherapy was retrospectively analyzed. The mean individual treatment dose (J/cm2), the mean number of sessions, and the mean total dose (J/cm2) were evaluated. Effectiveness was assessed by reviewing clinical examination notes from office visits.ResultsGood therapeutic efficacy was seen in patients with systemic sclerosis (SS, 16 patients), graft‐versus‐host disease (GVHD, 25 patients), and nephrogenic systemic fibrosis (NSF, 17 patients). A statistically significant a dose–response association was observed in the cases of SS, GVHD and NSF. Likelihood of clinical improvement from UVA1 phototherapy was very likely for medium‐ and high‐dose regimens in SS, while this level of improvement was only observed in GVHD and NSF patients receiving high‐dose UVA1.ConclusionUVA1 phototherapy is effective and safe in the treatment of GVHD, NSF, SS, and mast cell disorders. High‐dose regimens appear to be more effective than medium‐ and low‐dose regimens for NSF and GVHD, while medium‐ and high‐dose regimens outperform low‐dose UVA1 in SS.
Phylogenetic and Variable-Number Tandem-Repeat Analyses Identify Nonpathogenic Xanthomonas arboricola Lineages Lacking the Canonical Type III Secretion System
Authors: Essakhi Salwa , Cesbron Sophie , Fischer-Le Saux Marion , Bonneau Sophie , Jacques Marie-Agnès , Manceau Charles 
Published: June 2015

ABSTRACT

Xanthomonas arboricola
is conventionally known as a taxon of plant-pathogenic bacteria that includes seven pathovars. This study showed that
X. arboricola
also encompasses nonpathogenic bacteria that cause no apparent disease symptoms on their hosts. The aim of this study was to assess the
X. arboricola
population structure associated with walnut, including nonpathogenic strains, in order to gain a better understanding of the role of nonpathogenic xanthomonads in walnut microbiota. A multilocus sequence analysis (MLSA) was performed on a collection of 100
X. arboricola
strains, including 27 nonpathogenic strains isolated from walnut. Nonpathogenic strains grouped outside clusters defined by pathovars and formed separate genetic lineages. A multilocus variable-number tandem-repeat analysis (MLVA) conducted on a collection of
X. arboricola
strains isolated from walnut showed that nonpathogenic strains clustered separately from clonal complexes containing
Xanthomonas arboricola
pv. juglandis strains. Some nonpathogenic strains of
X. arboricola
did not contain the canonical type III secretion system (T3SS) and harbored only one to three type III effector (T3E) genes. In the nonpathogenic strains CFBP 7640 and CFBP 7653, neither T3SS genes nor any of the analyzed T3E genes were detected. This finding raises a question about the origin of nonpathogenic strains and the evolution of plant pathogenicity in
X. arboricola
. T3E genes that were not detected in any nonpathogenic isolates studied represent excellent candidates to be those responsible for pathogenicity in
X. arboricola
.
Changing adherence-related beliefs about ICS maintenance treatment for asthma: feasibility study of an intervention delivered by asthma nurse specialists
Authors: Chapman Sarah C E , Barnes Neil , Barnes Mari , Wilkinson Andrea , Hartley John , Piddock Cher , Weinman John , Horne Rob 
Published: June 2015

ObjectivesThe Necessity-Concerns Framework (NCF) posits that non-adherence to inhaled corticosteroids (ICS) in asthma is influenced by doubts about the necessity for ICS and concerns about their potential adverse effects. This feasibility study examined whether these beliefs could be changed by briefing asthma nurse specialists on ways of addressing necessity beliefs and concerns within consultations.DesignPre-post intervention study.SettingSecondary care.ParticipantsPatients with a diagnosis of moderate to severe asthma who were prescribed daily ICS were recruited to either a hospital care group (n=79; 71.0% female) or intervention group (n=57; 66.7% female).InterventionAsthma nurse specialists attended a 1.5-day NCF briefing.Primary and secondary outcome measuresBeliefs about ICS (primary outcome) and self-reported adherence were measured preconsultation and 1 month postconsultation. Participants also rated their satisfaction with their consultations immediately after the consultation. Consultation recordings were coded to assess intervention delivery.ResultsAfter the NCF briefing, nurse specialists elicited and addressed beliefs about medicine more frequently. The frequency of using the NCF remained low, for example, open questions eliciting adherence were used in 0/59 hospital care versus 14/49 (28.6%) intervention consultations. Doubts about personal necessity for, and concerns about, ICS were reduced at 1 month postbriefing (p<0.05), but the intervention was not applied extensively enough to improve adherence.ConclusionsThe intervention changed nurse consultations, but not sufficiently enough to fully address non-adherence or adherence-related ICS beliefs (necessity and concerns). More effective techniques are needed to support nurse specialists and other practitioners to apply the intervention in hospital asthma review consultations.
Risk assessment in acute non-variceal upper GI bleeding: the AIMS65 score in comparison with the Glasgow–Blatchford score in a Scottish population
Authors: Palmer Andrew J , Moroni Francesca , Mcleish Sally , Campbell Geraldine , Bardgett Jonathan , Round Joanna , McMullan Conor , Rashid Majid , Clark Robert , De Las Heras Dara , Vincent Claire 
Published: June 2015

IntroductionThe early use of risk stratification scores is recommended for patients presenting with acute non-variceal upper gastrointestinal (GI) bleeds (ANVGIB). AIMS65 is a novel, recently derived scoring system, which has been proposed as an alternative to the more established Glasgow–Blatchford score (GBS).ObjectiveTo validate the AIMS65 scoring system in a predominantly Caucasian population from Scotland and compare it with the GBS.DesignRetrospective study of patients presenting to a district general hospital in Scotland with a suspected diagnosis of ANVGIB who underwent inpatient upper GI endoscopy between March 2008 and March 2013.OutcomesThe primary outcome measure was 30-day mortality. Secondary outcome measures were requirement for endoscopic intervention, endoscopy refractory bleeding, blood transfusion, rebleeding and admission to high dependency unit (HDU) and intensive care unit (ICU). The area under the receiver operating characteristic (AUROC) curve was calculated for each score.Results328 patients were included. Of these 65.9% (n=216) were men and 34.1% (n=112) women. The mean age was 65.2 years and 30-day mortality 5.2%. AIMS65 was superior to the GBS in predicting mortality, with an AUROC of 0.87 versus 0.70 (p<0.05). The GBS was superior for blood transfusion (AUROC 0.84 vs 0.62, p<0.05) and admission to HDU (AUROC 0.73 vs 0.62, p<0.05). There were no significant differences between the scores with respect to requirement for endoscopic intervention, endoscopy refractory bleeding, rebleeding and admission to ICU.ConclusionsAIMS65 accurately predicted mortality in a Scottish population of patients with ANVGIB. Large prospective studies are now required to establish the exact role of AIMS65 in triaging patients with ANVGIB.
Simulating the thermorheological evolution of channel-contained lava: FLOWGO and its implementation in EXCEL
Authors: Harris Andrew J. L. , Rhéty Maéva , Gurioli Lucia , Villeneuve Nicolas , Paris Raphaël 
Published: June 2015

Abstract
FLOWGO is a one-dimensional model that tracks the thermorheological evolution of lava flowing down a channel. The model does not spread the lava but, instead, follows a control volume as it descends a line of steepest descent centred on the channel axis. The model basis is the Jeffreys equation for Newtonian flow, modified for a Bingham fluid, and a series of heat loss equations. Adjustable relationships are used to calculate cooling, crystallization and down-channel increases in viscosity and yield strength, as well as the resultant decrease in velocity. Here we provide a guide that allows FLOWGO to be set up in Excel. In doing so, we show how the model can be executed using a slope profile derived from Google™ Earth. Model simplicity and ease of source-term input from Google™ Earth means that this exercise allows (i) easy access to the model, (ii) quick, global application and (iii) use in a teaching role. Output is tested using measurements made for the 2010 eruption of Piton de la Fournaise (La Réunion Island). The model is also set up for rapid syneruptive hazard assessment at Piton de la Fournaise, as we show using the example of the response to the June 2014 eruption.
A two-hander
Authors: Harper Andy , Mackay Robin 
Published: June 2015

Abstract
In a series of works dating from 2013–2014, the British painter Andy Harper ‘doubles’ painted images using a direct form of contact printing. This operation on the part of the painter brings together the traditional practice of painting with the purely mechanical act of printing, a doubling of the image. The accompanying text considers the principle of symmetry implied in this act, through a reading of Kant’s early philosophy of space and the crucial role played in it by the notion of ‘handedness’ or orientation.
Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR: the LEAD study
Authors: Neggers Sebastian JCMM , Pronin Vyacheslav , Balcere Inga , Lee Moon-Kyu , Rozhinskaya Liudmila , Bronstein Marcello D , Gadelha Mônica R , Maisonobe Pascal , Sert Caroline , van der Lely Aart Jan , _ _ 
Published: June 2015

ObjectiveTo evaluate extended dosing intervals (EDIs) with lanreotide Autogel 120 mg in patients with acromegaly previously biochemically controlled with octreotide LAR 10 or 20 mg.Design and methodsPatients with acromegaly had received octreotide LAR 10 or 20 mg/4 weeks for ≥6 months and had normal IGF1 levels. Lanreotide Autogel 120 mg was administered every 6 weeks for 24 weeks (phase 1); depending on week-24 IGF1 levels, treatment was then administered every 4, 6 or 8 weeks for a further 24 weeks (phase 2). Hormone levels, patient-reported outcomes and adverse events were assessed. Primary endpoint: proportion of patients on 6- or 8-week EDIs with normal IGF1 levels at week 48 (study end).Results107/124 patients completed the study (15 withdrew from phase 1 and two from phase 2). Of 124 patients enrolled, 77.4% were allocated to 6- or 8-week EDIs in phase 2 and 75.8% (95% CI: 68.3–83.3) had normal IGF1 levels at week 48 with the EDI (primary analysis). A total of 88.7% (83.1–94.3) had normal IGF1 levels after 24 weeks with 6-weekly dosing. GH levels were ≤2.5 μg/l in >90% of patients after 24 and 48 weeks. Patient preferences for lanreotide Autogel 120 mg every 4, 6 or 8 weeks over octreotide LAR every 4 weeks were high.ConclusionsPatients with acromegaly achieving biochemical control with octreotide LAR 10 or 20 mg/4 weeks are possible candidates for lanreotide Autogel 120 mg EDIs. EDIs are effective and well received among such patients.
La campagne de presse des Amis de la Religion en faveur de l’intervention militaire française en Espagne en 1823
Authors: Dufour Gérard 
Published: June 2015

Cet article analyse la participation des deux principales revues ecclésiastiques de l’époque (L’Ami de la Religion et du Roi et Les Tablettes du clergé et des Amis de la Religion, fondés, réciproquement, en 1814 et 1822) à la véritable croisade que la presse ultra mena, dès la fin janvier 1820, en faveur d’une intervention militaire française en Espagne pour sauvegarder les droits « légitimes » du trône et de l’autel.Il montre comment l’information fournie aux ecclésiastiques français sur le sort réservé par les révolutionnaires à leurs collègues espagnols réveilla en eux le souvenir de la Terreur et des persécutions qu’ils avaient alors subies et qu’ils risquaient de devoir supporter de nouveau si l’on laissait le mal se propager et comment, à partir des nouvelles (vraies ou fausses) ainsi propagées, les prêtres poussèrent dans leurs prêches (avec le plus grand succès) les fidèles à manifester par des prières publiques leur souhait de voir la France restaurer Ferdinand VII comme souverain absolu.
Désir de liberté, citoyenneté et démocratie. Retour sur la question de l’actualité politique de Machiavel
Authors: Gaille Marie 
Published: June 2015

La pensée de Machiavel a fait l’objet, ces dernières décennies, de nombreuses références dans les réflexions sur les processus de démocratisation, sur la signification et les conditions de la liberté politique ou encore sur la participation civique. La présente contribution défend la thèse d’une actualité indirecte de Machiavel pour la théorie contemporaine de la démocratie, à travers le questionnement que son œuvre suscite sur le rôle du désir de liberté dans l’approfondissement de la démocratie. Sa pensée nous invite à nuancer le rôle que nous attribuons communément à l’institution de la citoyenneté en lien avec la Déclaration des droits de l’homme et du citoyen et la signification donnée à la « modernité » politique. Elle permet d’éclairer les ambivalences de la citoyenneté démocratique et d’interroger les limites de la conception participative de la démocratie.
Foucault et le conflit démocratique : le gouvernement du commun contre le gouvernement néolibéral
Authors: Sauvêtre Pierre 
Published: June 2015

Sur fond d’une critique du (néo)libéralisme, qui rend notamment inopérante l’idée de souveraineté populaire, l’article cherche à montrer qu’une conception de la démocratie intégrant le conflit doit être élaborée à partir du cadre théorique de la gouvernementalité. Il donne en ce sens comme critère de la démocratie l’existence d’une situation de gouvernementalités multiples. Il identifie enfin, comme alternative potentielle à la gouvernementalité néolibérale, le « gouvernement du commun » dont l’existence est aujourd’hui ce qui donne sens à la démocratie.
Malebranche à Genève : le De Inquirenda Veritate et sa Préface
Authors: Muceni Elena 
Published: June 2015

Traduite en anglais et en néerlandais, la Recherche de la Vérité a aussi fait l’objet, du vivant de son auteur, d’une traduction latine, le De Inquirenda Veritate. Réalisée entre 1682 et 1683, cette traduction, effectuée à partir de la troisième édition de l’ouvrage de Malebranche, est due au travail de Jacques Lenfant (1661-1728), à l’époque étudiant en théologie à l’Académie de Genève. Cette entreprise atteste de manière significative la réception du malebranchisme à Genève dans les années 1680 et fournit un témoignage de l’accueil favorable que le monde intellectuel lié à cette Académie réformée a réservé à la doctrine cartésienne, frappée à la même époque par de nombreuses censures, tant dans le monde catholique que dans le monde protestant. La Préface que Jacques Lenfant a préparée pour le De Inquirenda Veritate, dont nous proposons ici la traduction française, illustre bien ces deux aspects. Elle présente en effet une sorte d’apologie du cartésianisme et propose une interprétation de la pensée de Malebranche comme une philosophie qui suit et porte à son accomplissement, à travers ses développements éthiques et théologiques, la doctrine de Descartes.
Les Marranes
Authors: Bensoussan Albert 
Published: June 2015

Cet article propose une analyse historique, étymologique et philologique du mot marrano, ainsi qu’une brève étude de l’impact historique des Marranes. Ainsi, l’expression du marranisme dans le domaine littéraire sera abordée, à travers l’énigme « Duelos y quebrantos » dans Don Quichotte, la poésie burlesque d’Antón de Montoro, ou encore les œuvres de Mateo Alemán, où le marranisme devient vecteur romanesque dans Guzmán de Alfarache. Puis c’est la postérité des marranes et du marranisme qui sera abordée, avec les Xuetes de Majorque, l’œuvre d’Albert Cohen et l’évolution du concept sous la plume du sociologue Edgar Morin. L’auteur cherche donc à définir la trajectoire des marranes et du marranisme à travers les siècles et la pensée, jusqu’à nos jours.
La fábula esópica, los cuentos y los exempla del siglo xiv en el Baldo, un libro de caballerías del siglo XVI
Authors: Pastrana Santamarta Tomasa 
Published: June 2015

Una obra renacentista como el Baldo da cabida en sus páginas a fábulas esópicas y cuentos medievales que se han ido transmitiendo y adaptando en el transcurso de los siglos. El autor encuentra en este tipo de narraciones una forma directa y sencilla de exponer enseñanzas para, de este modo, justificar la existencia de los libros de caballerías, en un momento en que se suscita la polémica debido a su «falta de verosimilitud». La presencia de estos cuentos es una reivindicación de su utilidad a la hora de transmitir contenido didáctico, así como de su posición legítima dentro del saber humanístico del momento. En este estudio se presentan algunas de las fábulas y anécdotas que se mencionan e intercalan en el Baldo, y que se encuentran también presentes en obras muy representativas del siglo xiv, con la finalidad de analizar los cambios de contenido, uso y composición que existen en ellas.
La forêt des convoitises : cent ans de politiques sociales, libérales et environnementales dans les Parcs nationaux du Mexique (1910-2013)
Authors: Lebreton Clotilde , Héritier Stéphane , Arnould Paul , Imbernon Jacques 
Published: June 2015

L’histoire agraire et forestière du Mexique a conduit à la configuration d’un régime foncier forestier original fondé en partie sur la propriété collective. Les parcs nationaux mexicains présentent ainsi une situation singulière dans le contexte nord-américain, habitué à un propriétaire foncier unique, l’État fédéral. Ils constituent dans ce pays des entités territoriales d’une complexité législative, réglementaire, économique, politique et sociale considérable. L’héritage de la révolution mexicaine (1910-1917) a confié des droits aux communautés agraires souvent contestés par les politiques de conservation ou en opposition aux politiques libérales : d’un côté, les habitants des parcs se voient interdire certains usages, notamment forestiers, de l’autre, des entreprises concessionnaires privées ou para-publiques, se voient attribuer des droits d’exploitation. L’objectif de cet article est de reconstituer l’évolution des politiques de contrôle pour l’accès et l’utilisation des ressources forestières dans le Parc national du Nevado de Toluca et plus généralement dans les espaces naturels protégés du Mexique. Il analyse la manière dont s’est opérée la superposition des politiques publiques, tant à l’échelle nationale qu’à l’échelle du Parc. Le pluralisme légal conférant aux populations à la fois des droits agraires et des restrictions d’usage sur les ressources, est à l’origine des difficultés rencontrées dans la régulation des modes de gestion en présence et des problèmes plus généraux de gouvernance au sein d’espaces protégés mexicains.
Improved snow interception modeling using canopy parameters derived from airborne LiDAR data
Authors: Moeser D. , Stähli M. , Jonas T. 
Published: June 2015

AbstractForest snow interception can account for large snow storage differences between open and forested areas. The effect of interception can also lead to significant variations in sublimation, with estimates varying from 5 to 60% of total snowfall. Most current interception models utilize canopy closure and LAI to partition interception from snowfall and calculate interception efficiency as an exponential decrease of interception efficiency with increasing precipitation. However, as demonstrated, these models can show specific deficiencies within heterogeneous canopy. Seven field areas were equipped with 1932 surveyed points within various canopy density regimes in three elevation bands surrounding Davos, Switzerland. Snow interception measurements were taken from 2012 to 2014 (∼9000 samples) and compared with measurements at two open sites. The measured data indicated the presence of snow bridging from a demonstrated increase in interception efficiency as precipitation increased until a maximum was reached. As precipitation increased beyond this maximum, the data then exhibited a decrease in interception efficiency. Standard and novel canopy parameters were developed using aerial LiDAR data. These included estimates of LAI, canopy closure, distance to canopy, gap fraction, and various tree size parameters. These canopy metrics and the underlying efficiency distribution were then integrated to formulate a conceptual model based upon the snow interception measurements. This model gave a ∼27% increase in the r2 (from 0.39 to 0.66) and a ∼40% reduction in RMSE (from 5.19 to 3.39) for both calibration and validation data sets when compared to previous models at the point scale. When upscaled to larger grid sizes, the model demonstrated further increases in performance.
Solar wind energy input to the magnetosheath and at the magnetopause
Authors: Pulkkinen T. I. , Dimmock A. P. , Osmane A. , Nykyri K. 
Published: June 2015

AbstractUsing Time History of Events and Macroscale Interactions During Substorms observations, we show that the efficiency of the energy entry through the magnetopause as measured by the Poynting vector normal component depends on the combination of the solar wind speed and the southward component of the interplanetary magnetic field (IMF): Most efficient energy transfer occurs when the IMF BZ is only moderately negative, and the solar wind speed is high. This means that for the same level of solar wind driver parameters (electric field, epsilon, or other), different combinations of V and BZ will produce different driving at the magnetopause. The effect is strongest for low to moderate driving conditions, while the influence is smaller for the intense space weather events.
A two‐way interaction between the Hainan plume and the Manila subduction zone
Authors: Mériaux Catherine A. , Duarte João C. , Schellart Wouter P. , Mériaux Anne‐Sophie 
Published: June 2015

AbstractThe interaction between mantle plumes and subducting slabs is well accepted, but the influence of slabs on plumes has more often been portrayed than the reverse. Here we present three‐dimensional upper mantle laboratory models in which a compositional plume rises underneath a subducting plate. Slab/plume buoyancy flux ratios ranged between 7 and 18. The models exhibit a two‐way interaction. While the plume conduit increasingly tilts away from the trench as a result of slab rollback‐induced toroidal mantle flow, the slab subduction rate decreases as a function of the amount of plume buoyancy opposing that of the slab, which gets subducted beneath the slab. We propose that our models apply to the Hainan/Manila system and explain the recently imaged tilt of the Hainan plume by the Manila slab‐induced mantle return flow. The Hainan plume could lessen the Manila subduction rate from 8 Ma into the future.