bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Penguatan Profil Pelajar Pancasila pada Elemen Akhlak kepada Alam di SD
Authors: Erlina  , Sutisna Atang 
Published: July 2024

Sebagai pelajar Pancasila menyadari bahwa dirinya merupakan bagian dari ekosistem alam, maka manusia berkewajiban untuk menjaga lingkungan dan melestariakan alam agar kehidupan manusia tetap terjaga dan dapat hidup berkelanjutan. Penelitian ini bertujuan untuk menganalisis proses dan tahapan penguatan profil Pancasila pada elemen akhlak kepada alam melalui proyek tema gaya hidup berkelanjutan di SD Negeri 2 Bayuning. Metode penelitian ini menggunakan pendekatan kualitatif dengan tipe studi kasus. Subjek diambil dengan menggunakan teknik purposive sampling berdasarkan peringkat di kelas dan snowball sampling. Teknis analisis data menggunakan model Miles and Huberman meliputi reduksi data, data display (penyajian data), dan conclusion. Hasil dari penelitian ini menujukkan bahwa terdapat tahapan dan proses yang belum sesuai dengan pedoman pelaksana proyek pancasila (P5) yakni pembentukan tim fasilitator proyek P5 dan modul pelaksanaan proyek P5. Namun sekolah tetap melaksanakan proyek dengan bekerjasama dengan orangtua, komite sekolah, dinas Lingkungan Hidup, dan puskesmas untuk memperkuat profil pancasila pada elemen akhlak kepada alam.
Pengaruh Ketergantungan Gadget Melalui Behaviour Therapy Terhadap Perkembangan Sosial Anak Usia Dini
Authors: Efastri Sean Marta , Suharni  
Published: July 2024

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh ketergantungan gadget melalui behaviour therapy terhadap perkembangan sosial anak usia dini. Penelitian ini menggunakan jenis penelitian eksperimen. Menurut (Sugiyono, 2012) penelitian eksperimen dapat diartikan sebagai metode penelitian yang digunakan untuk mencari pengaruh perlakuan tertentu terhadap yang lain dalam kondisi yang terkendalikan. Metode yang akan digunakan dalam penelitian ini adalah metode penelitian eksperimen dengan desain Pre-Eksperimen (Pre-Experiment design) dengan jenis one group pretest and posttest. Menurut (Sugiyono, 2012) one group pretest and posttest design adalah suatu teknik untuk mengetahui efek sebelum dan sesudah pemberian perlakuan. Hasil dari penelitian ini yakni terdapat pengaruh behavior therapy terhadap perkembangan sosial anak usia dini yang ketergantungan pada gadget. Berdasarkan hasil analisis statistik t-test yang diperoleh yaitu thitung = 14,276 pada taraf kesalahan 0,05 atau 5% sehingga nilai ttabel = 2.145. Nilai tersebut menunjukkan perubahan yang signifikan terlihat dari nilai sig (2 tailed) sebesar 0,000. Karena nilai sig 0,000 ˂ 0,05 atau sig kecil dari 0,05, dengan demikian Ha diterima dan Ho ditolak. Sehingga dapat disimpulkan bahwa ada pengaruh behavior therapy terhadap perkembangan sosial anak usia dini yang ketergantungan pada gadget.
Impact of direct access on the quality of primary care musculoskeletal physiotherapy: a scoping review from a patient, provider, and societal perspective
Authors: Cattrysse Erik , Van Den Broeck Jona , Petroons Robin , Teugels Amber , Scafoglieri Aldo , Van Trijffel Emiel 
Published: July 2024

Introduction: Worldwide many countries provide direct access in physiotherapy. The aim of this scoping review was to synthesize the available evidence on the quality of primary care musculoskeletal physiotherapy from different perspectives.
Methods: Systematic searches were conducted in three databases up to September 2022. Studies were included when regarding assessment of at least one of the following perspectives: patient (quality of Life, patient satisfaction, pain, functioning, adverse events), provider (treatment compliance, responsibility, liability, status, prestige, job satisfaction), and society (number of referrals, amount of medical imaging, medication use, number of sessions needed for rehabilitation, and overall costs and cost-effectiveness). Selection and methodological quality assessment of systematic reviews were performed. Data extraction and analysis were performed separately for systematic reviews and individual primary studies.
Results: Five systematic reviews as well as 17 primary studies were included. From a patient perspective, no significant effect of direct access was found for pain and a tendency in favour of direct access was found for quality of life, functioning, and well-being. Concerning providers, higher treatment compliance was found in direct access to physiotherapy and decision-making was more accurate. From a societal perspective, significant differences in favour of direct access physiotherapy were found for waiting time, prescribed medication, and medical imaging. In addition, there was a tendency towards lower health care costs.
PEMBERDAYAAN TENAGA REKAM MEDIS TERKAIT PENGENALAN SISTEM APLIKASI PERANCANGAN SIMKLINIK
Authors: Nanta sigit Nanta sigit , Ariyanti Rea 
Published: July 2024

Klinik Modern merupakan satu diantara klinik rawat inap pratama yang terdapat di Kabupaten malang yang menyelenggarakan pelayanan kesehatan secara perorangan, dimana rata-rata kunjungan pasien di klinik moderna berkisar 50 pasien per hari. Setiap fasilitas pelayanan kesehatan termasuk klinik wajib menyelenggarakan rekam medis. Salah satu sistem yang dilaksanakan dalam unit rekam medis adalah Rekam medis elektronik merupakan rekam medis yang penyelenggaraannya dilakukan dengan sistem elektronik. Tujuan dari rekam medis adalah untuk meningkatkan mutu sebuah pelayanan kesehatan, memberikan kepastian hukum, kerahasiaan, keamanan, keutuhan serta ketersediaan data rekam medis pasien, dan mewujudkan sebuah penyelenggaraan berbasis digital yang terintegrasi. Rekam medis elektronik paling sedikit dilakukan kegiatan registrasi pasien, ditribusi data rekam medis elektronik, pengisisan informasi klinis, pengolahan informasi rekam medis elektronik, pengimputan data, penyimpanan data rekam medis elektronik, menjamin mutu , transfer isi rekam medis. Kegiatan ini dilaksanakan sebanyak 3 kali dengan metode sosialisasi dan diskusi interaktif mengenai pelaksanaan sistem penyimpanan rekam medis yang dilakukan kepada petugas kesehatan. Dari hasil evaluasi, diketahui bahwa pengetahuan petugas kesehatan antara sebelum dan sesudah diberikan sosialisasi meningkat sebesar 70%, dimana sebelum diberikan edukasi, rerata nilai pretest sebesar 56.00 dan setelah diberikan edukasi rerata nilai postest menjadi 95.00. Kegiatan ini perlu dilakukan sebagai upaya meningkatkan kemampuan petugas kesehatan dalam melakukan sistem perancangan aplikasi SIMKLINIK
Explainable coronary artery disease prediction model based on AutoGluon from AutoML framework
Authors: Wang Jianghong , Xue Qiang , Zhang Chris W. J. , Wong Kelvin Kian Loong , Liu Zhihua 
Published: July 2024

ObjectiveThis study focuses on the innovative application of Automated Machine Learning (AutoML) technology in cardiovascular medicine to construct an explainable Coronary Artery Disease (CAD) prediction model to support the clinical diagnosis of CAD.MethodsThis study utilizes a combined data set of five public data sets related to CAD. An ensemble model is constructed using the AutoML open-source framework AutoGluon to evaluate the feasibility of AutoML in constructing a disease prediction model in cardiovascular medicine. The performance of the ensemble model is compared against individual baseline models. Finally, the disease prediction ensemble model is explained using SHapley Additive exPlanations (SHAP).ResultsThe experimental results show that the AutoGluon-based ensemble model performs better than the individual baseline models in predicting CAD. It achieved an accuracy of 0.9167 and an AUC of 0.9562 in 4-fold cross-bagging. SHAP measures the importance of each feature to the prediction of the model and explains the prediction results of the model.ConclusionThis study demonstrates the feasibility and efficacy of AutoML technology in cardiovascular medicine and highlights its potential in disease prediction. AutoML reduces the barriers to model building and significantly improves prediction accuracy. Additionally, the integration of SHAP enhances model transparency and explainability, which is critical to ensuring model credibility and widespread adoption in cardiovascular medicine.
Increased impairment of cerebral autoregulation in COVID-19 associated pulmonary failure requiring extracorporeal membrane oxygenation
Authors: Thudium Marcus , Kappler Jochen , Oremek Maximilian J. G. , Ehrentraut Stefan Felix , Kornilov Evgeniya , Marinova Milka , Putensen Christian , Soehle Martin , Schewe Jens-Christian 
Published: July 2024

IntroductionCerebrovascular complications are feared but also commonly reported in patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) support therapy. Besides other reasons, a connection between impaired cerebral autoregulation and SARS-CoV-2 infection as a mechanism for an increase in cerebrovascular complications has been hypothesized.MethodsIn an observational single-center study, we investigated a cohort of 48 patients requiring veno-venous ECMO support therapy with (n = 31) and without SARS-CoV-2 infection (n = 17). Cerebral autoregulation was assessed with the cerebral oximetry-derived autoregulation index (ORx) based on a moving correlation between arterial pressure and cerebral oximetry.ResultsPatients with ECMO support therapy and SARS-CoV-2 experienced more time with impaired cerebral autoregulation than without SARS-CoV-2 [17 ± 9 vs. 13 ± 9% (p = 0.027)]. Patients with SARS-CoV-2 suffering from cerebrovascular complications had more time with impaired autoregulation than non SARS-CoV-2 patients with these complications (19 ± 9 vs. 10 ± 4%, p = 0.032).ConclusionOur results suggest a connection between SARS-CoV-2 and impaired cerebral autoregulation as well as cerebrovascular complications in SARS-CoV-2 patients.
Differential effects of domesticated and wild Capsicum frutescens L. on microbial community assembly and metabolic functions in rhizosphere soil
Authors: Wang Can , Zhang Yinghua , Wang Shaoxiang , Lv Xia , Xu Junqiang , Zhang Xueting , Yang Qing , Meng Fanlai , Xu Bin 
Published: July 2024

ObjectiveRhizosphere microorganisms play crucial roles in the growth and development of plants, disease resistance, and environmental adaptability. As the only wild pepper variety resource in China, domesticated Capsicum frutescens Linn. (Xiaomila) exhibits varying beneficial traits and affects rhizosphere microbial composition compared with its wild counterparts. In this study, we aimed to identify specific rhizosphere microbiome and metabolism patterns established during the domestication process.MethodsThe rhizosphere microbial diversity and composition of domesticated and wild C. frutescens were detected and analyzed by metagenomics. Non-targeted metabolomics were used to explore the differences of metabolites in rhizosphere soil between wild and domesticated C. frutescens.ResultsWe found that the rhizosphere microbial diversity of domesticated variety was significantly different from that of the wild variety, with Massilia being its dominant bacteria. However, the abundance of certain beneficial microbes such as Gemmatimonas, Streptomyces, Rambibacter, and Lysobacter decreased significantly. The main metabolites identified in the wild variety included serylthreonine, deoxyloganic acid, vitamin C, among others. In contrast, those identified in the domesticated group were 4-hydroxy-l-glutamic acid and benzoic acid. Furthermore, the differentially enriched pathways were concentrated in tyrosine and tryptophan biosynthesis, histidine and purine-derived alkaloids biosynthesis, benzoic acid family, two-component system, etc.ConclusionThis study revealed that C. frutescens established specific rhizosphere microbiota and metabolites during domestication, which has important significance for the efficient utilization of beneficial microorganisms in breeding and cultivation practices.
Endoscopic variceal ligation combined with sclerotherapy for management of gastroesophageal variceal bleeding in pediatric patients: a single-center retrospective study
Authors: Li Ming-Ming , Sun Fang , Huai Man-Xiu , Qu Chun-Ying , Shen Feng , Zhang Yi , Xu Lei-Ming 
Published: July 2024

ObjectivesPortal hypertension (PH) frequently gives rise to severe and life-threatening complications, including hemorrhage accompanied by the rupture of esophageal and gastric varices. In contrast to the guidelines for the management of PH in adults, the optimal endoscopic management of variceal bleeding for secondary prophylaxis in children remains unclear. The present study evaluated the efficacy and safety of endoscopic variceal ligation (EVL) and endoscopic sclerotherapy (EST) to control gastroesophageal variceal bleeding in children.MethodsThis retrospective study included children with gastroesophageal variceal bleeding who underwent EST or EVL at Xinhua Hospital, Shanghai Jiaotong University School of Medicine, between February 2013 and March 2020. Short-term hemostasis rate and long-term rebleeding rate were evaluated. Adverse events related to the procedures, such as esophageal ulcer, esophageal stricture, abnormal embolization, pneumonia and perforation, were also recorded.ResultsEVL (n = 8) and EST (n = 13) were performed successfully in all pediatric patients diagnosed with moderate to severe esophageal varices concurrent with gastric varices. Hemostasis was achieved during episodes of upper gastrointestinal bleeding. The mean volume of each single aliquot of cyanoacrylate injected was 0.3 ± 0.1 ml (range: 0.1–0.5 ml). Varices were eradicated in six (75%) of the eight patients who underwent EVL after a median 2 (range: 1–4) procedures and a median time of 3.40 months (range: 1.10–13.33 months). Eleven (52.4%) of the 21 patients developed rebleeding events, with the mean duration of hemostasis being 11.1 ± 11.6 months (range 1.0–39.2 months). No treatment-related complications, for example, distal embolism, occurred except for abdominal pain in one patient (4.8%).ConclusionsEST, alone or in combination with EVL, is an effective and safe method of managing gastroesophageal variceal hemorrhage in children undergoing secondary prophylaxis.
Effects of Cascara Cherry and Other Coffee Litter Mulching on Soil Properties, Photosynthesis, and Water Use Efficiency of Coffea Canephora Pierre ex A. Froehner cv. Reyan No.1 Seedling
Authors: Zhang Ang , Chen Su-Sen , Lin Xing-Jun , Yan Lin , Huang Yan-Li , Sun Yan , Zhao Qing-Yun , Zhao Shao-Guan , Li Li-Hua , Long Yu-Zhou , Dong Yun-Ping 
Published: July 2024

Mulching cultivation with agricultural wastes is the main production pattern of coffee at present, but the effect of mulching cultivation on photosynthetic physiological processes of coffee plants is still not clear. Therefore, a randomized block design was adopted to establish a field experiment by one-year-old Coffee Canephora seedlings in this study. There were four types of mulch treatments, including non-mulch coffee waste (C), mulching coffee litter (L), mulching coffee cascara (cherry pericarp, P), and mulching coffee litter and cascara (LP) in this field experiment. Soil properties and microenvironment (e.g., moisture, temperature, pH, bulk density, organic matter content, alkali-hydrolyzed nitrogen content, available potassium content, and available potassium content), agronomic traits (e.g., specific leaf area, leaf area index, plant height, and relative chlorophyll content), and photosynthetic indices (e.g., photosynthesis, transpiration, respiration, stomatal conductance, intercellular CO2 concentration, water use efficiency, and carbon use efficiency) were investigated to determine the effects of different coffee waste mulches on the photosynthetic physiology of coffee seedlings. The results show that coffee litter and cascara mulch significantly reduced soil temperature by 0.42 or 0.33 °C, respectively, and coffee litter rather than cascara mulch significantly increased the soil’s available potassium content by 46.28%, although coffee waste mulch did not affect other soil properties or microenvironment indices; coffee cascara mulching significantly increased the specific leaf area and net and gross photosynthesis of coffee by 45.46%, 78.33%, and 91.72%, respectively, but the mulching treatments did not affect stomatal conductance, transpiration, or carbon use efficiency in this study. Additionally, coffee cascara mulching increased leaf respiration and net and gross water use efficiency by 109.34%, 80.54%, and 104.95%, respectively. The coffee cascara mulching alone had the most significant positive impact on the photosynthetic index, followed by a combination of litter and cascara, litter alone, and the control treatment. The observed variations in the coffee photosynthetic index may be attributed to the reduction of soil temperature caused by mulching treatments rather than the increase in soil nutrients content. These results indicate that coffee cascara mulching could effectively promote photosynthesis and the growth of coffee seedlings by improving the soil microenvironment.
Syntaxonomical Remarks on the Garrigues from Apulia (S Italy) and Neighboring Territories
Authors: Tomaselli Valeria , Sciandrello Saverio , Minissale Pietro , Forte Luigi , Costanzo Emanuele , Giusso del Galdo Gianpietro , Carruggio Francesca , Pazienza Gaetano , Brullo Salvatore 
Published: July 2024

In this study, the garrigues occurring in Apulia and neighboring territories (southern Italy) were surveyed in order to clarify their syntaxonomical arrangement. Many contributions previously focused on this vegetation type, often adopting different and sometimes contrasting treatments from both the nomenclature and syntaxonomical aspects. Our investigations are supported by the multivariate analysis of a dataset containing 292 phytosociological relevés, whose resulting cluster dendrogram highlights the hierarchical relationships between the examined plant communities. Overall, twenty-one associations with several sub-associations were recognized. Some of them are already known in the literature, whereas others are described here for the first time. As concerns the syntaxonomical framework, this vegetation is attributable to the class Cisto cretici-Micromerietea julianae, which in this territory is represented by the order Cisto eriocephali-Ericetalia manipuliflorae and by two alliances: Cisto eriocephali-Ericion multiflorae, grouping the more thermophilous associations usually distributed along coastlines and at low altitudes; and Cytiso spinescentis-Saturejion montanae, including the mesophilic associations occurring in mountain and sub-mountain belts.
Chemical Profiling of Drimys granadensis (Winteraceae) Essential Oil, and Their Antimicrobial, Antioxidant, and Anticholinesterase Properties
Authors: Cartuche Luis , Vallejo Camila , Castillo Edison , Cumbicus Nixon , Morocho Vladimir 
Published: July 2024

A complete and comprehensive chemical and biological study of Drimys granadensis, a native Ecuadorian aromatic plant, was conducted. By conventional steam distillation from dried leaves, a yellowish, translucent essential oil (EO) with a density of 0.95 and a refractive index of 1.5090 was obtained. The EO was analyzed by gas chromatography coupled to a mass spectrometer (GC/MS) and an FID detector (GC/FID), respectively. Enantiomeric distribution was also carried out by GC/MS using a chiral selective column (diethyl tert-butylsilyl-BETA-cyclodextrin). The microdilution broth method was employed to assess the antibacterial and antifungal activity of the EO against a panel of opportunistic microorganisms. Antioxidant capacity was measured using diphenyl picryl hydrazyl (DPPH) and azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals. Finally, the inhibitory potential of the EO against acetylcholinesterase was also valued. Sixty-four chemical compounds, constituting 93.27% of the total composition, were identified, with major components including γ-muurolene (10.63%), spathulenol (10.13%), sabinene (5.52%), and δ-cadinene (4.22%). The characteristic taxonomic marker of the Drimys genus, Drimenol, was detected at very low percentages (<2%). Two pairs of enantiomers ((1S,5R)-(+)-α-pinene/(1S,5S)-(–)-α-pinene; (1S,5R)-(+)-β-pinene/(1S,5S)-(–)-β-pinene) and one pure enantiomer (1R,4S)-(–)-camphene were identified. Regarding antimicrobial potency, the EO exhibited a significant moderate effect on Listeria monocytogenes with a minimal inhibitory concentration (MIC) value of 250 µg/mL, while with the remaining microorganisms, it exerted less potency, ranging from 500 to 2000 µg/mL. The EO displayed moderate effects against the ABTS radical with a half scavenging capacity of 210.48 µg/mL and no effect against the DPPH radical. The most notable effect was noticed for acetylcholinesterase, with a half inhibition concentration (IC50) of 63.88 ± 1.03 µg/mL. These antiradical and anticholinesterase effects hint at potential pharmacological applications in Alzheimer’s disease treatment, although the presence of safrole, albeit in low content (ca. 2%), could limit this opportunity. Further in vivo studies are necessary to fully understand their potential applications.
Recurrent urinary tract infections and prophylactic antibiotic use in women: a cross-sectional study in primary care
Authors: Sanyaolu Leigh , Best Victoria , Cannings-John Rebecca , Wood Fiona , Edwards Adrian , Akbari Ashley , Hayward Gail , Ahmed Haroon 
Published: July 2024

BackgroundDespite the considerable morbidity caused by recurrent urinary tract infections (rUTIs), and the wider personal and public health implications from frequent antibiotic use, few studies adequately describe the prevalence and characteristics of women with rUTIs or those who use prophylactic antibiotics.AimTo describe the prevalence, characteristics, and urine profiles of women with rUTIs with and without prophylactic antibiotic use in Welsh primary care.Design and settingThis was a retrospective cross-sectional study in Welsh general practice using the Secure Anonymised Information Linkage (SAIL) Databank.MethodThe characteristics of women aged ≥18 years with rUTIs or using prophylactic antibiotics from 2010 to 2020, and associated urine culture results from 2015 to 2020, are described.ResultsIn total, 6.0% (n= 92 213/N= 1 547 919) had rUTIs, and 1.7% (n= 26 862/N= 1 547 919) were prescribed prophylactic antibiotics with the rates increasing after 57 years of age. Only 49.0% (n=13 149/N= 26 862) of users of prophylactic antibiotics met the definition of rUTIs before initiation. The study found that 80.8% (n= 44 947/N= 55 652) of women with rUTIs had a urine culture result in the preceding 12 months with high rates of resistance to trimethoprim and amoxicillin. Of women taking prophylactic antibiotics, 64.2% (n= 9926/N= 15 455) had a urine culture result before initiation and 18.5% (n= 320/N= 1730) of women prescribed trimethoprim had resistance to it on the antecedent sample.ConclusionA substantial proportion of women had rUTIs or incident prophylactic antibiotic use. However, 64.2% (n= 9926/N= 15 455) of women had urine cultured before starting prophylaxis. There was a high proportion of cultured bacteria resistant to two antibiotics used for rUTI prevention and evidence of resistance to the prescribed antibiotic. More frequent urine cultures for rUTI diagnosis and before prophylactic antibiotic initiation could better inform antibiotic choices.