bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed Adenoneuroendocrine Carcinoma of the Colon Progressed Rapidly After Hepatic Rupture: Report of a Case
Authors: Ito Hiromitsu , Kudo Atsushi , Matsumura Satoshi , Ban Daisuke , Irie Takumi , Ochiai Takanori , Nakamura Noriaki , Tanaka Shinji , Tanabe Minoru 
Published: January 2014

Abstract
The rupture of a metastatic mixed adenoneuroendocrine carcinoma (MANEC) has not been previously reported, although the neuroendocrine cell carcinoma is often associated with a high incidence of hepatic metastases. The patient was a 39-year-old male who presented with upper abdominal pain over 3 months. Computed tomography showed multiple tumors in both hepatic lobes, while lower gastrointestinal endoscopy revealed a tumor in the transverse colon. Histopathologic examination of the tumor revealed it to be a neuroendocrine cell carcinoma. After the resection of the primary tumor, hepatic metastases rapidly increased, and one of them in the left lateral segment was ruptured with significant hemorrhage. The rupture led us to undertake the emergency operation to stop the bleeding. Histology showed a high-grade large-cell neuroendocrine carcinoma associated with moderately differentiated tubular adenocarcinoma. The Ki-67 labeling index was 80% (G3). The diagnosis was mixed adenoneuroendocrine carcinoma according to the 2010 World Health Organization guidelines. Hepatic arterial infusion chemotherapy, systemic chemotherapy, and transcatheter arterial chemoembolization did not decrease the tumor progress, and the patient died on postoperative day 110. Reporting this highly malignant case, I hope all doctors can be interested in MANEC.
Comment on a perspective: Molecular detections of new agents in finfish—Interpreting biological significance for fish health management
Authors: Mordecai Gideon , Di Cicco Emiliano , Deeg Christoph , Bateman Andrew , Teffer Amy , Miller Kristi 
Published: July 2024

Abstract
Impact statement The rapid development of genomic technologies has begun a new paradigm in the study and management of emerging infectious diseases. To inform the conservation of fish, here we examine different perspectives on how to determine thresholds for management action in the context of molecular tools and fisheries policy.
Adaptive fuzzy ABLF function fixed‐time tracking control method for nonlinear fault‐tolerant control systems with event triggering mechanism
Authors: You Guodong , Li Xingyun , Wu Jinyuan , Xu Bin , Ge Leijiao , Shen Zhifang , Zhang Hailong 
Published: July 2024

SummaryAs the nonlinearities of many real physical controlled systems become stronger and stronger, they are difficult to be described by accurate mathematical models. For a class of nonlinear single‐input single‐output systems with all‐state constraints and actuator faults, an event‐triggered adaptive fuzzy ABLF function fixed‐time tracking control method is proposed. The asymmetric barrier Lyapunov function (ABLF) combined with backward step technique is used to ensure the boundedness of the closed‐loop system output. In order to solve the problem of limited bandwidth resources, this paper adopts the event trigger mechanism and fuzzy control technology to approximate the unknown function to ensure the convergence of the system in a fixed time. After theoretical analysis, it is proved that the tracking error of the system converges in the small neighborhood of the origin, and it still has good tracking performance when the actuator faults. Finally, by comparing the proposed method with the asymmetric barrier Lyapunov function, which verifies the effectiveness of the proposed method.
Direct Fabrication of 3D Electrodes Based on Graphene and Conducting Polymers for Supercapacitor Applications
Authors: Jimoh Musibau Francis , Carson Gray Scott , Anderson Mackenzie Babetta , El‐Kady Maher F. , Kaner Richard B. 
Published: July 2024

AbstractThe development of commercially viable composite conducting polymer electrodes for energy storage is limited by the requirement of multiple and complex fabrication steps, low energy density, and poor cycling stability. In this work, a straightforward, economical, single‐step method is developed for creating densely packed nanostructured PEDOT/graphene composite material demonstrating its application as an electrode for supercapacitors. The electrode achieved the highest mass loading reported so far in the literature for composite vapor phase polymerized PEDOT/rGO using aqueous FeCl3 (25.2 mg cm−2), and displayed an ultrahigh areal capacitance of 4628.3 mF cm−2 at 0.5 mA cm−2. The symmetric two‐electrode setup displayed an energy density of 169.3 µWh cm−2 and a 70% capacitance retention after 70 000 cycles, showcasing its exceptional performance and durability.
Electron Donor–Acceptor Activated Single Atomic Sites for Boosting Oxygen Reduction Reaction
Authors: Ye Shenghua , Zhang Dantong , Ou Zhijun , Zheng Lirong , Liu Wenchao , Chen Wenda , Xu Yuan , Li Yongliang , Ren Xiangzhong , Ouyang Xiaoping , Xue Dongfeng , Yan Xueqing , Zhang Qianling , Liu Jianhong 
Published: July 2024

AbstractFabricating efficient non‐platinum‐group‐metal catalysts for the oxygen reduction reaction (ORR) in proton‐exchange membrane fuel cells still remains a big challenge. This study creates a unique bamboo‐like architecture of Mn and Fe single atomic sites (SASs) anchored on core‐shell structure of nanopaticles@carbon nanotubes (MnFe SASs/NPs@CNTs) via a precursor route, where the Fe nanoparticles (NPs) (identified as γ‐Fe and Austenite) are confined into CNTs, such an architecture exhibits compelling ORR activity and durability in 0.1 m HClO4. Experiments and calculations both reveal that the electron donor–acceptor paradigm between Mn SASs and Fe NPs launches a lattice‐electron coupling mechanism not only increasing occupation of π‐antibonding orbital in Mn−*O intermediates but also rising Jahn–Teller effect, thereby destabilize the Mn−*O intermediate and eventually facilitate the potential‐limiting step from *O to *OH. Such a coupling activation of the ORR‐inert Mn SASs greatly improves ORR performances of MnFe SASs/NPs@CNTs.
Bilayer Borophenes Exhibit Silicon‐Like Bandgap and Carrier Mobilities
Authors: Xu Ying , Wang Zhenxian , Xuan Xiaoyu , Zhang Zhuhua , Guo Wanlin 
Published: July 2024

AbstractBorophene, a boron analogue of graphene, is typically metallic, while all bulk boron phases are insulating. Here, we predict by first‐principles calculations that recently synthesized bilayer borophene, being suggested to be composed of two stacked v1/12 sheets, is a semiconductor with a bandgap of 1.13 eV, almost the same as that of silicon. It is shown that the stacking mode between two boron sheets as well as the density and pattern of the interlayer boron‐boron (B─B) bonds are the key factors for opening the bandgap in the otherwise metallic boron sheet. Moreover, the bilayer borophene exhibits electron mobility of 878.6 cm2 V−1 s−1 and a significantly higher optical absorption coefficient in the visible region than silicon. These excellent electronic and optical properties hosted in a two atom‐thick space, together with high thermal and mechanical stability, position the bilayer borophene as a promising nanomaterial for maintaining the miniaturization of electronics.
Electron Bridge Effect Induced by Oxygen‐Bridged Ga on PdMo Bimetallene Nanoribbons for Boosting Electrocatalytic Alkynol Semihydrogenation
Authors: Wang Wenxin , Yang Ruidong , Mao Qiqi , Mu Xu , Yu Hongjie , Deng Kai , Wang Jianguo , Wang Liang , Wang Hongjing 
Published: July 2024

AbstractThe utilization of green hydrogen sources in H2O for alkynols electrocatalytic semihydrogenation reaction (ESHR) at ambient temperature provides a promising pathway toward the sustainable conversion of alkynols. However, it is still a great challenge to construct specific interfacial structure to adjust the electronic structure of Pd for the purpose of altering the strong adsorption of Pd with active hydrogen to enhance the production of alkenols. Here, the atomically dispersed GaOx‐PdMo bimetallene nanoribbons (GaOx‐PdMo BNRs) via oxygen bridging Ga atoms is designed to the surface of PdMo BNRs for 2‐methyl‐3‐butyn‐2‐ol (MBY) ESHR to the synthesis of 2‐methyl‐3‐buten‐2‐ol (MBE). The GaOx‐PdMo BNRs achieve the excellent MBE selectivity (≈97.4%), Faraday efficiency (≈96.1%), and maintain long‐term stability. Density functional theory demonstrates that the top electron‐enriched Ga atoms and the bottom electron‐deficient Pd atoms construct a “pyramidal” interface via the oxygen bridge. The unique surface can effectively activate H2O and weaken interaction between catalyst and MBE, thus promoting MBE generation. Moreover, the electron bridge effect between Ga‐O‐PdMo can induce p‐d orbital hybridization to achieve lower the d‐band center of surface Pd thus modulating the reactants adsorption. This work provides a strategy to improve ESHR performance by electron bridge effect to modulate interfacial electron distribution.
Redirecting Tumor Evolution with Nanocompiler Precision for Enhanced Therapeutic Outcomes
Authors: Sun Wenshe , Cai Biao , Zhao Zejun , Li Shilun , He Yutian , Xie Shaowei 
Published: July 2024

AbstractPrecisely programming the highly plastic tumor expression profile to render it devoid of drug resistance and metastatic potential presents immense challenges. Here, a transformative nanocompiler designed to reprogram and stabilize the mutable state of tumor cells is introduced. This nanocompiler features a trio of components: 2‐deoxy‐d‐glucose‐modified lipid nanoparticles to inhibit glucose uptake, iron oxide nanoparticles to induce oxidative stress, and a deubiquitinase inhibitor to block adaptive protein profile changes in tumor cells. By specifically targeting the hypermetabolic nature of tumors, this approach disrupted their energy production, ultimately fostering a state of vulnerability and impeding their ability to adapt and resist. The results of this study indicate a substantial reduction in tumor growth and metastasis, thus demonstrating the potential of this strategy to manipulate tumor protein expression and fate. This proactive nanocompiler approach promises to steer cancer therapy toward more effective and lasting outcomes.
Bidirectional, Multilayer MXene/Polyimide Aerogels for Ultra‐Broadband Microwave Absorption
Authors: Wang Xin , Chen Xiaoming , He Qingyuan , Hui Yaozu , Xu Chaofan , Wang Baichuan , Shan Feihu , Zhang Jie , Shao Jinyou 
Published: July 2024

AbstractTo obtain high‐performance electromagnetic microwave (EM) absorption materials with broad effective absorption bandwidth (EAB) and reduced thickness, designing structures has proved to be a promising way. Herein, ultra‐broadband multilayer bidirectional MXene/polyimide EM absorption aerogels containing multi‐structures on scales ranging from the micro‐ to the macroscale are produced with the aid of electric and temperature fields. On the microscale, under the action of electric force and temperature gradient, the ordered structures made of aligned Ti3C2Tx MXene nanosheets and the microscale layered aerogel walls enable the bidirectional aerogel to achieve a wide EAB of 8.58 GHz at a thickness of 2.1 mm. This is ascribed to the numerous aligned nanosheets and layered aerogel walls perpendicular to the incident EMs, facilitating the conversion of electromagnetic energy into electrical energy. Furthermore, on the macroscale, the multilayer bidirectional aerogel with non‐gradient structures effectively resolves the conflict between impedance matching and energy loss, resulting in an ultrawide EAB of 9.41 GHz at a thickness of 3 mm. This innovative design of electric‐field‐assisted multilayer bidirectional aerogels with multiscale structural coupling may provide feasible and effective pathways for the development of advanced EM absorption materials.
Recent Advances in Self‐Powered Electrochemical Biosensors for Early Diagnosis of Diseases
Authors: Galstyan Vardan , D'Onofrio Ilenia , Liboà Aris , De Giorgio Giuseppe , Vurro Davide , Rovati Luigi , Tarabella Giuseppe , D'Angelo Pasquale 
Published: July 2024

AbstractModern sensing technologies are highly required for health monitoring. In this respect, the development of small‐size, high‐performance, and self‐powered biosensors for detecting and quantifying disease markers in biofluids can bring crucial changes and improvements to the concept of health monitoring systems. Clinical trials identify a wide range of biomarkers in biofluids that provide significant health information. Research into novel functional materials with outstanding properties opens up new perspectives for fabricating new‐generation biosensors. Furthermore, energy conversion and storage units are investigated to integrate them into biosensors and develop self‐powered systems. Electrochemical methods are very attractive for applications in biosensor technology, both in terms of biomarker detection and energy generation. Here the recent achievements in research into self‐powered electrochemical biosensors to detect sweat and saliva biomarkers are presented. Potential biomarkers for efficient analysis of these fluids are discussed in light of their importance in identifying various diseases. The influence of electrode materials on the performance of sensors is discussed. Progress in developing operating strategies for self‐powered electrochemical monitoring systems is also discussed. A summary and outlook are presented, mentioning major achievements and current issues to be explored.
Catalytic Deoxygenative Transformation of Ketoacids/Esters for the Synthesis of Coumarin, Benzofuranone, and Dihydrobenzo[b]oxepin‐2(3H)‐one Derivatives
Authors: Yadav Naveen , Khan Jabir , Kumar Hazra Chinmoy 
Published: July 2024

AbstractWe disclose herein a triflic acid and silane‐promoted reductive deoxygenative transformation of ketoacid/esters for the divergent synthesis of different‐sized lactones, which hold substantial significance in pharmaceutical and natural product chemistry. Owing to the simple reaction conditions and setup, this protocol features broad substrate generality, scalability, and good functional group tolerance, including late‐stage functionalization of pharmaceutical compounds and natural products. The control experiments and detailed NMR study provide insight into the reaction mechanism.
Synthesis of Cyclohexenone(aryl)iodonium Salts and Their Application in Construction of Fused aza‐Heterocyclic Skeletons
Authors: Zhang Shuoshuo , Xu Lingzhi , Li Xuemin , Yang Zhifang , Shi Haofeng , Li Yadong , Du Yunfei 
Published: July 2024

AbstractA class of cyclohexenone(aryl)iodonium salts was readily prepared from 2‐iodocyclohexenones and arenes under mild conditions. This novel series of hypervalent iodonium building blocks exhibits dual characteristics of hyperiodonium salts and α,β‐unsaturated cyclic ketones, enabling access to intricate aza‐heterocycles. The reaction of these cyclohexenone(aryl)iodonium salts with arylamines or aryl sulfonamides affords 2‐acylaziridines, while with 2‐aminobenzimidazoles or 2‐aminoimidazoles leads to the formation of the 1H‐imidazo[1,2‐a]imidazole‐fused compounds. The transformation is postulated to proceed through an exclusive hyperiodonium‐mediated N‐Michael addition followed by N‐annulation cascade.
Recent Advances on Direct Phosphorothiolation Reactions
Authors: Zheng Haifa , Peng Ju , Liu Xiang , Zhao Ping 
Published: July 2024

AbstractOrganophosphorothioates are organic molecules containing sulfur and phosphorus, with significant biological activity and physicochemical properties, widely used in organic synthesis, medicinal chemistry, and the agrochemical industry. In particular, many phosphorothioates display a variety of biological activities, such as antifungal, antibacterial, anti‐parasite, anticancer, and so on. Traditionally, the synthesis of phosphorothioates has mainly relied on indirect methods involving the construction of S−P bond. In recent years, direct phosphorothiolation has gained attention as a reliable and rapid method for introducing the −S−P(O)(OR)2 group into parent molecules. This article reviews the latest advances in direct phosphorothiolation reactions, categorized based on the different sources of the −S−P(O)(OR)2 group.
Rapid (Deuterio)difluoromethylation of Heteroatoms Using R‐22 Gas: A Demonstration of Flow Chemistry in Suppressing Intrinsic Reaction Pathways
Authors: Leung Hon Cheung , Lee Tsz Chun , Wong Wing‐Tak , Fu Wai Chung 
Published: July 2024

AbstractR‐22 gas (ClCF2H) is utilized in continuous flow for the installation of CF2H and CF2D groups on heteroatoms. A judiciously designed flow system suppresses the intrinsic SN2 reaction between heteroatom anions and ClCF2H, allowing for selective carbene‐based fragment coupling to yield X‐CF2D products with deuterium incorporation levels up to 96%. A broad scope of X–CF2H and X–CF2D products (X=S, O, N) is obtained with a short residence time of 5 minutes and scalability is demonstrated.
Generalized Interphase Design for Stabilized Li/Inorganic Electrolyte Interfaces
Authors: Liu Hong , Li Dabing , Dong Chenxin , Li Yang , Yuan Haocheng , Yu Dengfeng , Gao Lei , Ding Peipei , Li Yue , Qin Zuoyu , Liang Ying , Luo HanLin , Li Liangliang , Ren Yaoyu , Fan Li‐Zhen , Nan Ce‐Wen 
Published: July 2024

AbstractAll‐solid‐state Li metal batteries (ASSLMBs) using inorganic solid‐state electrolytes (ISEs) are considered promising energy storage technologies owing to their intrinsic safety and high energy density. Nevertheless, one critical challenge confronting ASSLMBs is the inability of the ISEs to prevent Li dendrite growth, which has not yet been fully addressed. Herein, general design principles of artificial solid electrolyte interphases (ASEI) for suppressing Li dendrites in ASSLMBs are proposed by systematically exploring the formation mechanism of Li dendrites. Subsequently, a tailored LiF‐Li3N ASEI is constructed to inspect the Li‐dendrite‐free design principles. The LiF‐Li3N modified Li (LFN‐Li) can effectively inhibit the side reactions and suppress the growth of Li dendrites, thus boosting the critical current densities of Li10GeP2S12 (LGPS) to a record‐high value of 3.4 mA cm−2. Furthermore, the LFN‐Li/LGPS/LFN‐Li can cycle stably for over 5000 h at 0.2 mA cm−2. Crucially, the versatility of the designed ASEI is highlighted as it ensures outstanding long‐term stability in symmetric cells featuring oxide Li1.3Al0.3Ti1.7(PO)3 or halide Li2ZrCl6 ISEs. As a result, the ASEI enables LiNi0.8Mn0.1Co0.1O2/LGPS/LFN‐Li and FeS2/LGPS/LFN‐Li cells to achieve high discharge‐specific capacities and desirable cyclic stability at room temperature. The generalized ASEI design principles rationalize the development of high‐energy ASSLBMs.
Species‐tree topology impacts the inference of ancient whole‐genome duplications across the angiosperm phylogeny
Authors: McKibben Michael T. W. , Finch Geoffrey , Barker Michael S. 
Published: July 2024

AbstractPremiseThe history of angiosperms is marked by repeated rounds of ancient whole‐genome duplications (WGDs). Here we used state‐of‐the‐art methods to provide an up‐to‐date view of the distribution of WGDs in the history of angiosperms that considers both uncertainty introduced by different WGD inference methods and different underlying species‐tree hypotheses.MethodsWe used the distribution synonymous divergences (Ks) of paralogs and orthologs from transcriptomic and genomic data to infer and place WGDs across two hypothesized angiosperm phylogenies. We further tested these WGD hypotheses with syntenic inferences and Bayesian models of duplicate gene gain and loss.ResultsThe predicted number of WGDs in the history of angiosperms (~170) based on the current taxon sampling is largely similar across different inference methods, but varies in the precise placement of WGDs on the phylogeny. Ks‐based methods often yield alternative hypothesized WGD placements due to variation in substitution rates among lineages. Phylogenetic models of duplicate gene gain and loss are more robust to topological variation. However, errors in species‐tree inference can still produce spurious WGD hypotheses, regardless of method used.ConclusionsHere we showed that different WGD inference methods largely agree on an average of 3.5 WGD in the history of individual angiosperm species. However, the precise placement of WGDs on the phylogeny is subject to the WGD inference method and tree topology. As researchers continue to test hypotheses regarding the impacts ancient WGDs have on angiosperm evolution, it is important to consider the uncertainty of the phylogeny as well as WGD inference methods.
Landscape and conservation genetics of western black crested gibbons (Nomascus concolor) in China
Authors: Orkin Joseph D. , He Kai , Hu Nai‐qing , Guan Zhen‐hua , Huang Bei , Yang Chunyan , Fan Peng‐fei , Jiang Xuelong 
Published: July 2024

AbstractDespite decades of field study, very little is known about the molecular ecology of gibbons, particularly as it relates to their ability to disperse across degraded and fragmentary landscapes. The critically endangered western black crested gibbon (Nomascus concolor) has been reduced to a small, fragmented population with about 1300 individuals. In the largest population genetic study of free‐ranging gibbons to date, we sampled 47 of these gibbons from 13 sites in China and generated 15 polymorphic autosomal microsatellite markers. We identify three population clusters of N. concolor in Yunnan centered in 1) the Wuliang and Ailao Mountains, 2) the Yongde Daxueshan Mountains, and 3) an isolated remnant near the border with Vietnam. Within the Wuliang Mountains, we identified four subclusters, three of which are bounded by high‐altitude rhododendron forest, and one that is isolated from the main population by ~2 km of degraded forest and pasture. Least‐cost path analysis and isolation by resistance modeling demonstrates that the population genetic distances among gibbons in Wuliangshan National Nature Reserve are significantly correlated with geographic paths that avoid use of high‐altitude rhododendron forest in favor of evergreen broadleaf forest. Although these gibbons have likely undergone reductions in heterozygosity from recent consanguineous mating, we suggest that their active avoidance of inbreeding on the population level maintains higher than expected levels of genetic diversity. This research provides new insights into how gibbons interact with heterogeneous environments and expands our understanding of their molecular ecology and conservation genetics.
Associations of cerebral amyloid beta and tau with cognition from midlife
Authors: Gonzales Mitzi M. , O'Donnell Adrienne , Ghosh Saptaparni , Thibault Emma , Tanner Jeremy , Satizabal Claudia L. , Decarli Charles S. , Fakhri Georges El , Johnson Keith A. , Beiser Alexa S. , Seshadri Sudha , Pase Matthew 
Published: July 2024

AbstractINTRODUCTIONUnderstanding early neuropathological changes and their associations with cognition may aid dementia prevention. This study investigated associations of cerebral amyloid and tau positron emission tomography (PET) retention with cognition in a predominately middle‐aged community‐based cohort and examined factors that may modify these relationships.METHODS11C‐Pittsburgh compound B amyloid and 18F‐flortaucipir tau PET imaging were performed. Associations of amyloid and tau PET with cognition were evaluated using linear regression. Interactions with age, apolipoprotein E (APOE) ε4 status, and education were examined.RESULTSAmyloid and tau PET were not associated with cognition in the overall sample (N = 423; mean: 57 ± 10 years; 50% female). However, younger age (< 55 years) and APOE ε4 were significant effect modifiers, worsening cognition in the presence of higher amyloid and tau.DISCUSSIONHigher levels of Aβ and tau may have a pernicious effect on cognition among APOE ε4 carriers and younger adults, suggesting a potential role for targeted early interventions.Highlights
Risk and resilience factors influenced cognitive vulnerability due to Aβ and tau.
Higher fusiform tau associated with poorer visuospatial skills in younger adults.
APOE ε4 interacted with Aβ and tau to worsen cognition across multiple domains.