bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operational Control and Managing Change: The Integration of Nontechnical Skills With Workplace Procedures
Authors: Thorogood J.L.. L. , Crichton M.T.. T. 
Published: May 2013

Summary
Some of the common pitfalls and problems associated with managing operations are discussed, with suggestions about how these can be addressed. Existing literature on human error, operational decision making, and industrial psychology is combined with the authors' experiences in researching these problems and working with operations teams. The nontechnical skills required to manage operations effectively are described together with the organizational structures and work processes that best support operations. Techniques for training teams and helping them to develop the competencies to manage operations safely and to deal with uncertainty are explained.
Mindful that “proper planning prevents poor performance,” engineers go to considerable lengths to create quality plans. A structured well-delivery process is followed, complete with peer reviews, risk assessments, and technical sign-offs. Deliverables include statements of requirements, basis-of-design documents, hazard identification (HAZID) sessions, drill-the-well-on-paper meetings, and a drilling program.
Despite these preparations, teams make decisions during operations with sometimes costly consequences, especially when surprised by an unexpected event or when facing high levels of uncertainty. This problem is not unusual and typically occurs when a project team fails to prepare and actively manage its transition from planning to operations, and to anticipate the necessary change in the functions of the team. Planning and operations require completely different mindsets. The lack of preparation for this transition stems from a common assumption that the team that has performed the planning is more than capable of managing a dynamic operation effectively. Research has identified that two different modes are required—during the planning phase, teams produce a plan designed to solve a problem, whereas during operations the team has to manage a task requiring the ability to adapt dynamically to shifting demands of the situation.
Effective operations management requires both a high degree of operational discipline and teams that are skilled in dealing with the unexpected and making decisions in time-constrained situations. These skills are not intuitive and must be taught, trained, practiced, and assessed. The protocols and decision rights must be clear, and the team must be trained so that it executes these functions in a fluent and competent manner.
The oil industry lacks an international regulatory framework enjoyed by aviation. It lacks even basic standardization about how rigs are operated, wells are drilled, and operations are monitored. These are essential prerequisites for an environment within which a standardized operational discipline can be developed and implemented. The purpose of this paper is, therefore, to propose a framework for operational governance within which the development of nontechnical-skills training can be built.
Spring and summer patterns in flowering onset, duration, and constancy across a water‐limited gradient
Authors: Crimmins Theresa M. , Crimmins Michael A. , Bertelsen C. David 
Published: May 2013

• Premise of the study: Community‐level flowering patterns can be characterized by onset, duration, and end as well as constancy, the degree to which species commence, cease, and reinitiate flowering within a season. In the mountainous Sky Islands region of the southwestern United States, flowering onset is clearly influenced by elevation in the spring, but much less so in the summer season. We evaluated whether these flowering metrics reflect these dissimilar patterns between distinct spring and summer seasons regarding the influence of the elevation and moisture gradient.• Methods: We characterized flowering onset, end, duration, and constancy by plant functional type and their relationships to climate variables in spring and summer. We also evaluated the influence of climate on seasonal flowering patterns.• Key results: Gaps in seasonal flowering occur frequently in this system in both seasons and among all plant functional types. In both seasons, annual plants exhibit the shortest flowering durations and highest constancies, and plants at low elevations, inhabiting environments with variable moisture conditions, show a greater tendency for longer flowering durations and lower constancy than high‐elevation plants. Spring flowering characteristics are most influenced by the total amount of October–March precipitation as well as temperatures in these months, whereas summer flowering characteristics are influenced by the timing of summer‐season precipitation, and next by the total amount of summer precipitation.• Conclusions: Flowering metrics, especially constancy and duration, show similar patterns in spring and summer and vary across elevation and moisture gradients. These patterns have substantial implications for plant and animal communities.
The phylogeny of the European high mountain genus Adenostyles (Asteraceae‐Senecioneae) reveals that edaphic shifts coincide with dispersal events
Authors: Dillenberger Markus S. , Kadereit Joachim W. 
Published: May 2013

• Premise of the study: Heterogeneity of edaphic conditions plays a large role in driving the diversification of many plant groups. In the Alps and other European high mountains, many closely related calcicole and calcifuge plant taxa exist. To better understand patterns and processes of edaphic differentiation, the phylogeny of the edaphically variable genus Adenostyles was studied. The genus contains three species, of which A. alpina has five subspecies. Each species and subspecies is largely confined to either calcareous or noncalcareous substrates.• Methods: We analyzed the phylogeny of Adenostyles using DNA sequences of nrITS, nrETS, nuclear chalcone synthase, and three plastid markers (rpl32‐trnL, psbA‐trnH, and ndhF‐rpl32) from 45 in‐group and five out‐group samples. The phylogeny was used to reconstruct ancestral edaphic associations and distribution areas.• Key results: Within Adenostyles alpina, the shifts of edaphic association from calcicole to calcifuge in subsp. briquetii (Corsica) and in a clade of subsp. macrocephala (southernmost Italy) plus subsp. pyrenaica (Pyrenees) coincide with dispersal events.• Conclusions: We conclude that colonization of areas with novel edaphic conditions via dispersal can trigger shifts of edaphic association. Accordingly, edaphic niche shifts can result from chance events.
Le « scandale d'une véritable christologie » (Karl Barth). ( Das Ärgernis einer wirklichen Christologie ). Penser Dieu révélé en Jésus
Authors: Holzer Vincent 
Published: May 2013

Il est assez rare que la christologie soit intégrée à la compréhension et à la résolution du rapport entre philosophie et théologie. En effet, l’intégration de la christologie à la « résolution » d’un problème d’ordre philosophique pose en soi difficulté, car il porte les germes inévitables et équivoques d’un « philosophisme » christologique dont ne saurait se satisfaire la doctrine de foi. Une christologie a priori (Idée du Christ) est toujours tentante. Elle encourt le risque de n’être qu’un chiffre de l’anthropologie qui se transcende. Or, la dimension sotériologique est indissociable de la christologie chrétienne. Elle l’est d’autant plus qu’elle plonge ses racines dans des sources vétérotestamentaires, pour s’épanouir dans les christologies néotestamentaires qu’unifie la confession de foi dans la Seigneurie du Christ glorifié. Aucune possibilité d’échappatoire ne saurait s’offrir à une christologie qui veut rester chrétienne, c’est-à-dire enracinée dans l’Écriture de la promesse. La question est plutôt de savoir ce que la confession de foi dans la Seigneurie du Christ éclaire et fonde quant à notre intelligence de la réalité comme telle, surtout si l’on admet, en reprenant une proposition inattendue de Maurice Merleau-Ponty, que « l’Incarnation change tout » ( Sens et non-sens , Paris, Nagel, 1948 ; repris par Gallimard, 1997, « foi et bonne foi », p. 310-311 ; 212-213). La prise en charge philosophique de l’Incarnation ne signifie pas nécessairement une conceptualisation de l’Incarnation, mais une interprétation philosophique du phénomène de l’Incarnation. Merleau-Ponty ne vide pas l’Incarnation de sa dimension phénoménale. Elle est intégrée comme une composante intelligible de l’« entrelacs » ou du « chiasme » qui caractérise la raison perceptive, autrement dit une raison qui ne s’absolutise pas et qui demeure ouverte au « sens primitif de l’Être ». Cette « ouverture à l’être » est identique à ce que Merleau-Ponty appelle, dans le Visible et l’invisible , la « foi perceptive ». Dans cette étude, je me propose d’apporter un éclairage christologique à la question du rapport entre philosophie et théologie en mettant cette question à l’épreuve d’une célèbre proposition de Karl Barth selon laquelle Schleiermacher ne serait pas parvenu, dans sa conception des rapports de l’homme à Dieu, à honorer le « scandale d’une véritable christologie ».
Malheurs et défis de la raison théologique : Ratio et idée de la foi chez Pierangelo Sequeri
Authors: Sèbe Jean-Baptiste 
Published: May 2013

L’article se propose d’examiner les effets de l’appel de Benoît XVI à « élargir les espaces de rationalité sous le signe d’une foi amie de l’intelligence » en lisant l’œuvre du théologien milanais P. Sequeri. Ce théologien traverse la tradition chrétienne en constatant que les relations entre foi et raison ne sont jamais parvenues à établir clairement un discours satisfaisant sur un fondement anthropologique du croire. Raison et foi ont laissé beaucoup d’énergie à délimiter leur influence. Sequeri plaide pour une réhabilitation anthropologique du croire comme lieu convergent des efforts mutuels de la foi et de la raison.
Éloge de la métaphysique en christianisme
Authors: Capelle Philippe 
Published: May 2013

Comment et pourquoi le christianisme a-t-il fait surgir en son sein une lignée « métaphysique » ? L’article s’efforce sous le mode de l’éloge, de montrer comment toute tentative de clarifier ce qu’il faut bien appeler la tradition chrétienne de la métaphysique doit passer par une réflexion renouvelée sur la question du « principe », ainsi que S. Breton s’y était engagé, mais aussi sur le statut de l’antique et moderne « philosophia christiana ». Il s’achève par la reprise de la notion de création, faisant valoir ses implications au bénéfice d’une pensée philosophique de l’alliance.
Dieu et l'ambivalence de l'être
Authors: Marion Jean-Luc 
Published: May 2013

Faut-il aborder la nomination de Dieu à partir de l’être ou en s’exceptant de cet horizon ? Avant de choisir entre Dieu sans l’être et Dieu avec l’être , il faut au moins préciser ce qu’on pourrait entendre sous le titre d’être. Depuis les analyses de Heidegger, il apparaît plus clairement qu’être peut se penser soit selon la subsistance dans le présent, soit en vue de l’advenue du présent par l’avenir. Si la première manière conduit à restreindre le Dieu de la Révélation à son idole métaphysique, doit-on penser qu’en retour la deuxième manière permettrait d’accepter l’advenue du Dieu révélé en Jésus-Christ ? Pareille hypothèse impliquerait-elle à son tour quelque chose comme une approche chrétienne de l’advenue du présent ?
An Essential Role for C5aR Signaling in the Optimal Induction of a Malaria-Specific CD4+ T Cell Response by a Whole-Killed Blood-Stage Vaccine
Authors: Liu Taiping , Xu Guilian , Guo Bo , Fu Yong , Qiu Yuan , Ding Yan , Zheng Hong , Fu Xiaolan , Wu Yuzhang , Xu Wenyue 
Published: May 2013

Abstract
The protective immunity induced by the whole-killed parasite vaccine against malarial blood-stage infection is dependent on the CD4+ T cell response. However, the mechanism underlying this robust CD4+ T cell response elicited by the whole-killed parasite vaccine is still largely unknown. In this study, we observe that immunization with Plasmodium yoelii–parasitized RBC lysate activates complement C5 and generates C5a. However, the protective efficacy against P. yoelii 17XL challenge is considerably reduced, and the malaria-specific CD4+ T cell activation and memory T cell differentiation are largely suppressed in the C5aR-deficient (C5aR−/−) mice. An adoptive transfer assay demonstrates that the reduced protection of C5aR−/− mice is closely associated with the severely impaired CD4+ T cell response. This is further confirmed by the fact that administration of C5aR antagonist significantly reduces the protective efficacy of the immunized B cell–deficient mice. Further study indicates that the defective CD4+ T cell response in C5aR−/− mice is unlikely involved in the expansion of CD4+CD25+Foxp3+ T cells, but strongly linked to a defect in dendritic cell (DC) maturation and the ability to allostimulate CD4+ T cells. These results demonstrate that C5aR signaling is essential for the optimal induction of the malaria-specific CD4+ T cell response by the whole-killed parasite vaccine through modulation of DCs function, which provides us with new clues to design an effective blood-stage subunit vaccine and helps us to understand the mechanism by which the T cell response is regulated by the complement system.
Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells
Authors: Wu Tao , Young James S. , Johnston Heather , Ni Xiong , Deng Ruishu , Racine Jeremy , Wang Miao , Wang Audrey , Todorov Ivan , Wang Jianmin , Zeng Defu 
Published: May 2013

Abstract
Prevention of chronic graft-versus-host disease (cGVHD) remains a major challenge in allogeneic hematopoietic cell transplantation (HCT) owing to limited understanding of cGVHD pathogenesis and lack of appropriate animal models. In this study, we report that, in classical acute GVHD models with C57BL/6 donors and MHC-mismatched BALB/c recipients and with C3H.SW donors and MHC-matched C57BL/6 recipients, GVHD recipients surviving for &gt;60 d after HCT developed cGVHD characterized by cutaneous fibrosis, tissue damage in the salivary gland, and the presence of serum autoantibodies. Donor CD8+ T cells were more potent than CD4+ T cells for inducing cGVHD. The recipient thymus and de novo–generated, donor-derived CD4+ T cells were required for induction of cGVHD by donor CD8+ T cells but not by donor CD4+ T cells. Donor CD8+ T cells preferentially damaged recipient medullary thymic epithelial cells and impaired negative selection, resulting in production of autoreactive CD4+ T cells that perpetuated damage to the thymus and augmented the development of cGVHD. Short-term anti-CD4 mAb treatment early after HCT enabled recovery from thymic damage and prevented cGVHD. These results demonstrate that donor CD8+ T cells cause cGVHD solely through thymic-dependent mechanisms, whereas CD4+ T cells can cause cGVHD through either thymic-dependent or independent mechanisms.
Advanced 3D Food Printing with Simultaneous Cooking and Generative AI Design
Authors: Lee Connie Kong Wai , Xu Yang , Yuan Qiaoyaxiao , Chan Yee Him , Poon Wing Yan , Zhong Haosong , Chen Siyu , Li Mitch Guijun 
Published: February 2025

Abstract3D food printing is an indispensable technology for emerging food technologies. However, conventional nonconcurrent postprocessing methods limit the final food quality, including the unappealing nature of food ink modification, imperfections in retaining the desired food shape, and the risk of microbial contamination. Here, an artificial intelligence (AI)‐enhanced solution is developed to achieve extrusion‐based printing with simultaneous infrared heating, enabling in‐line and rapid cooking of complex starch‐based food. Noncontact graphene heaters as cooking sources present outstanding food quality control with microbial studies, microstructure analysis, and heat transfer simulation models. This integrative 3D food printing method with AI‐enhanced food pattern generation and in‐situ cooking significantly expands the applications for customized food creation. It paves the way for the broader adoption of heating‐based 3D printing of functional materials.
Analysis of factors influencing the relationship between voriconazole plasma concentrations and adverse effects in a paediatric population
Authors: Hikino Keiko , Shoji Kensuke , Saito Jumpei , Fukunaga Koya , Liu Xiaoxi , Matsui Toshihiro , Utano Tomoyuki , Takebayashi Akira , Tomizawa Daisuke , Kato Motohiro , Matsumoto Kimikazu , Ishikawa Takashi , Kawai Toshinao , Nakamura Hidefumi , Miyairi Isao , Terao Chikashi , Mushiroda Taisei 
Published: February 2025

AimsThe influence of CYP2C19 polymorphisms on voriconazole plasma concentrations is recognized, but its extent, other contributing factors and risks for adverse reactions remain under‐explored.MethodsThis study focused on Japanese paediatric patients recruited between 2020 and 2022 treated with voriconazole. We specifically investigated the occurrence of cholestasis and thrombocytopenia as adverse reactions of voriconazole. Voriconazole plasma levels were modelled in a previous study using a population pharmacokinetics approach. Missing values were estimated with a Bayesian method in Phoenix NLME. We analysed CYP2C19*2, CYP2C19*3 and CYP2C19*17. Clinical and laboratory data were collected before and after voriconazole treatment.ResultsAmong the 60 patients (mean age: 6.5 years; 53.3% male), 38 had haematological malignancies, 18 inborn errors of immunity, 2 solid tumours and 2 other diseases. Adverse reactions occurred in 12 patients. The voriconazole plasma concentrations were significantly higher in those experiencing these adverse reactions (mean normalized concentrations: 0.66 in cases vs. −0.16 in controls, P = .025), with a trend towards higher concentrations in carriers of the CYP2C19*2 or *3 alleles (mean normalized concentrations: 0.98 in carrier cases vs. 0.016 in noncarrier cases, P = .14). A predictive model for voriconazole concentrations, incorporating carriership of CYP2C19*2 or *3, C‐reactive protein levels, and platelet counts, showed a summed variance explained of 23.6% with the variance attributable to CYP2C19*2 or *3 carrier status alone was 2.6%. Including carrier status improved the area under the receiver operating characteristic curve for predicting adverse reactions to 0.70.ConclusionsOur findings underscore the role of the CYP2C19 polymorphism in voriconazole‐induced thrombocytopenia and cholestasis.
Quantification of Glycosaminoglycans in Urine by Isotope Dilution Liquid Chromatography‐Electrospray Ionization Tandem Mass Spectrometry
Authors: Zhang Haoyue , Beasley James , Menkovic Iskren , Stiles Ashlee , Millington David S. , Young Sarah P. 
Published: February 2025

AbstractMucopolysaccharidoses (MPSs) are complex lysosomal diseases that result in the accumulation of glycosaminoglycans (GAGs) in urine, blood, and tissues. Lysosomal enzymes responsible for GAG degradation are defective in MPSs. GAGs including chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS), and keratan sulfate (KS) are biomarkers for MPSs. This article describes a stable isotope dilution‐tandem mass spectrometric method for quantifying CS, DS, and HS in urine samples. The GAGs are methanolyzed to uronic/iduronic acid‐N‐acetylhexosamine or uronic/iduronic acid‐N‐glucosamine dimers and mixed with internal standards derived from deuteriomethanolysis of GAG standards. Specific dimers derived from HS, DS, and CS are separated by ultra‐performance liquid chromatography (UPLC) and analyzed by electrospray ionization (ESI) tandem mass spectrometry (MS/MS) using selected reaction monitoring for each targeted GAG product and its corresponding internal standard. This UPLC‐MS/MS GAG assay is useful for identifying patients with MPS types I, II, III, VI, and VII. © 2025 Wiley Periodicals LLC.Basic Protocol: Urinary GAG analysis by ESI‐MS/MSSupport Protocol 1: Prepare calibration samplesSupport Protocol 2: Preparation of stable‐isotope‐labeled internal standardsSupport Protocol 3: Preparation of quality controls for GAG analysis in urineSupport Protocol 4: Optimization of methanolysis timeSupport Protocol 5: Measurement of methanolic HCl concentrationSupport Protocol 6: Preparation of working methanolic HCl solution (1.1 M)Support Protocol 7: Dilution of prepared urine sample
Profiling second language writing teachers: Discourses from the published literature
Authors: Yu Shulin 
Published: February 2025

AbstractIn L2 writing education, the topic of L2 writing teachers, who play critical roles in nurturing and shaping students' L2 writing abilities across diverse educational and social contexts, has received proliferating research attention over the past decades. Despite the accumulated studies in the investigation of L2 writing teachers, nonexistent studies have provided a holistic and comprehensive picture of L2 writing teachers in terms of their unique identities and complex experiences of teaching and learning to teach (Hirvela & Belcher, 2007; Lee, 2010). Therefore, this position paper reports discourses from the published literature on L2 writing teachers by addressing the ten key questions in this area, respectively, on L2 writing teachers' roles, beliefs and perspectives, identities, writing teaching, feedback giving, assessment, received education, and expertise development. These ten questions respond to the “what” in L2 writing teachers (such as roles, identity, and beliefs), and the “how” of L2 writing teachers, including how they instruct, provide feedback, assess, and develop professional expertise. This conceptual paper sheds light on multiple dimensions of L2 writing teachers to reveal a holistic and comprehensive picture of L2 writing teachers in terms of their beliefs, practices, and experiences of teaching and learning to teach.
Design of an Early Year's Intervention With and for the Community: A Needs Assessment and Gap Analysis
Authors: Nelson Helen J. , Munns Ailsa , Burns Sharyn K. 
Published: February 2025

ABSTRACTIssue AddressedOutcomes of health and wellbeing are shaped in the first 5 years as childrens' brains and bodies develop in response to their environment. Families at sociodemographic disadvantage face barriers to early intervention that may be reduced through access to integrated care across health, early education, and welfare services. There is, however, internationally documented evidence of difficulty in sustaining and translating such services. This needs assessment sought to understand existing knowledge on creating safe, accessible integrated service hubs for families with young children, providing a foundation for longitudinal evidence‐based translation of early intervention into practise.MethodsBuilding on a formative evaluation, this needs assessment analysed data to identify strengths and gaps in support for children pre‐birth to age 5 and their families in the low socioeconomic area of Armadale, Western Australia, including mapping, definition of family, and review of evidence for outcome measures.ResultsCombined evidence identified priorities to support access in a location of unmet need in the local government area. The focus on one‐place that is culturally safe with trained professionals empowering people using a relational model of care to build trust for families who have experienced disadvantage through poverty and social barriers.ConclusionsWe identified a priority to empower families through consumer engagement and co‐design, with a need for evidence‐based measures to evaluate intervention effectiveness. This provides a focus for ongoing intervention development and research and evaluation.Relevance to Health PromotionThis needs assessment provides an example of health promotion action towards evidence‐based early years support.