bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper‐loaded Milk‐Protein Derived Microgel Preserves Cardiac Metabolic Homeostasis After Myocardial Infarction
Authors: Hong Xiaoqian , Tian Geer , Dai Binyao , Zhou Xuhao , Gao Ying , Zhu Lianlian , Liu Haoran , Zhu Qinchao , Zhang Liwen , Zhu Yang , Ren Daxi , Guo Chengchen , Nan Jinliang , Liu Xianbao , Wang Jian'an , Ren Tanchen 
Published: July 2024

AbstractMyocardial Infarction (MI) is a leading cause of death worldwide. Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling after MI. However, whether material‐derived cues can treat MI through metabolic regulation is mainly unexplored. Herein, a Cu2+ loaded casein microgel (CuCMG) aiming to rescue the pathological intramyocardial metabolism for MI amelioration is developed. Cu2+ is an important ion factor involved in metabolic pathways, and intracardiac copper drain is observed after MI. It is thus speculated that intramyocardial supplementation of Cu2+ can rescue myocardial metabolism. Casein, a milk‐derived protein, is screened out as Cu2+ carrier through molecular‐docking based on Cu2+ loading capacity and accessibility. CuCMGs notably attenuate MI‐induced cardiac dysfunction and maladaptive remodeling, accompanied by increased angiogenesis. The results from unbiased transcriptome profiling and oxidative phosphorylation analyses support the hypothesis that CuCMG prominently rescued the metabolic homeostasis of myocardium after MI. These findings enhance the understanding of the design and application of metabolic‐modulating biomaterials for ischemic cardiomyopathy therapy.
TRIM65/NF2/YAP1 Signaling Coordinately Orchestrates Metabolic and Immune Advantages in Hepatocellular Carcinoma
Authors: Bian Zhixuan , Xu Chang , Wang Xiaoying , Zhang Baohua , Xiao Yixuan , Liu Li , Zhao Shasha , Huang Nan , Yang Fengjiao , Zhang Yue , Xue Shaobo , Wang Xiongjun , Pan Qiuhui , Sun Fenyong 
Published: July 2024

AbstractHepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide. Significantly activated uridine nucleotide and fatty acid metabolism in HCC cells promote malignant proliferation and immune evasion. Herein, it is demonstrated that the tripartite motif 65 (TRIM65) E3 ubiquitin‐protein ligase, O‐GlcNAcylated via O‐GlcNAcylation transferase, is highly expressed in HCC and facilitated metabolic remodeling to promote the accumulation of products related to uracil metabolism and palmitic acid, driving the progression of HCC. Mechanistically, it is showed that TRIM65 mediates ubiquitylation at the K44 residue of neurofibromatosis type 2 (NF2), the key protein upstream of classical Hippo signaling. Accelerated NF2 degradation inhibits yes‐associated protein 1 phosphorylation, inducing aberrant activation of related metabolic enzyme transcription, and orchestrating metabolic and immune advantages. In conclusion, these results reveal a critical role for the TRIM family molecule TRIM65 in supporting HCC cell survival and highlight the therapeutic potential of targeting its E3 ligase activity to alter the regulation of proteasomal degradation.
Core‐Shell Gel Nanofiber Scaffolds Constructed by Microfluidic Spinning toward Wound Repair and Tissue Regeneration
Authors: Dong Yue , Ding Zongkun , Bai Yuting , Lu Ling‐Yu , Dong Ting , Li Qing , Liu Ji‐Dong , Chen Su 
Published: July 2024

AbstractGrowing demand for wound care resulting from the increasing chronic diseases and trauma brings intense pressure to global medical health service system. Artificial skin provides mechanical and microenvironmental support for wound, which is crucial in wound healing and tissue regeneration. However, challenges still remain in the clinical application of artificial skin since the lack of the synergy effect of necessary performance. In this study, a multi‐functional artificial skin is fabricated through microfluidic spinning technology by using core‐shell gel nanofiber scaffolds (NFSs). This strategy can precisely manipulate the microstructure of artificial skin under microscale. The as‐prepared artificial skin demonstrates superior characteristics including surface wettability, breathability, high mechanical strength, strain sensitivity, biocompatibility and biodegradability. Notably, this artificial skin has the capability to deliver medications in a controlled and sustained manner, thereby accelerating the wound healing process. This innovative approach paves the way for the development of a new generation of artificial skin and introduces a novel concept for the structural design of the unique core‐shell gel NFSs.
Seeing Through Muddy Water: Laser‐Induced Graphene for Portable Tomography Imaging
Authors: Zhong Haosong , Lu Xupeng , Yang Rongliang , Pan Yexin , Lin Jing , Kim Minseong , Chen Siyu , Li Mitch Guijun 
Published: July 2024

AbstractDue to its outstanding physical and chemical properties, graphene synthesized by laser scribing on polyimide (PI) offers excellent opportunities for photothermal applications, antiviral and antibacterial surfaces, and electrochemical storage and sensing. However, the utilization of such graphene for imaging is yet to be explored. Herein, using chemically durable and electrically conductive laser‐induced graphene (LIG) for tomography imaging in aqueous suspensions is proposed. These graphene electrodes are designed as impedance imaging units for four‐terminal electrical measurements. Using the real‐time portable imaging prototypes, the conductive and dielectric objects can be seen in clear and muddy water with equivalent impedance modeling. This low‐cost graphene tomography measurement system offers significant advantages over traditional visual cameras, in which the suspended muddy particles hinder the imaging resolution. This research shows the potential of applying graphene nanomaterials in emerging marine technologies, such as underwater robotics and automatic fisheries.
A study of methanol‐to‐olefins packed bed reactor performance using particle‐resolved CFD and machine learning
Authors: Zhu Li‐Tao , Kenig Eugeny Y. 
Published: July 2024

AbstractIn this study, particle‐resolved computational fluid dynamics (CFD) simulations were performed to analyze fluid flow, mass transport, and reaction phenomena in methanol‐to‐olefins packed bed reactors with diverse cylindrical configurations and operating conditions. Utilizing validated CFD data, data‐driven surrogate models were developed based on several representative machine learning (ML) techniques. Comprehensive training and optimization of ML model hyperparameters were performed, followed by a comparative assessment of their capabilities to predict reactor performance. Subsequently, data‐driven surrogate models together with CFD simulations were applied to optimize catalyst structure design and operating conditions. Finally, a hybrid approach was developed that couples the ML‐aided data‐driven model with a genetic algorithm‐based multi‐objective optimization. The resulting hybrid method was applied to find the Pareto‐optimal compromise between pressure drop and light olefins yield.
Electrolyte Design Enables Rechargeable LiFePO4/Graphite Batteries from −80 °C to 80 °C
Authors: Li Zeheng , Yao Yu‐Xing , Zheng Mengting , Sun Shuo , Yang Yi , Xiao Ye , Xu Lei , Jin Cheng‐Bin , Yue Xin‐Yang , Song Tinglu , Wu Peng , Yan Chong , Zhang Qiang 
Published: July 2024

AbstractLithium iron phosphate (LFP)/graphite batteries have long dominated the energy storage battery market and are anticipated to become the dominant technology in the global power battery market. However, the poor fast‐charging capability and low‐temperature performance of LFP/graphite batteries seriously hinder their further spread. These limitations are strongly associated with the interfacial lithium (Li)‐ion transport. Here we report a wide‐temperature‐range ester‐based electrolyte that exhibits high ionic conductivity, fast interfacial kinetics and excellent film‐forming ability by regulating the anion chemistry of Li salt. The interfacial barrier of the battery is quantitatively unraveled by employing three‐electrode system and distribution of relaxation time technique. The superior role of the proposed electrolyte in preventing Li0 plating and sustaining homogeneous and stable interphases are also systematically investigated. The LFP/graphite cells exhibit rechargeability in an ultrawide temperature range of −80 °C to 80 °C and outstanding fast‐charging capability without compromising lifespan. Specially, the practical LFP/graphite pouch cells achieve 80.2 % capacity retention after 1200 cycles (2 C) and 10‐min charge to 89 % (5 C) at 25 °C and provide reliable power even at −80 °C.
Quantum Dot‐Based FRET Nanosensors for Talin‐Membrane Assembly and Mechanosensing
Authors: Ntadambanya Audrey , Pernier Julien , David Violaine , Susumu Kimihiro , Medintz Igor L. , Collot Mayeul , Klymchenko Andrey , Hildebrandt Niko , Le Potier Isabelle , Le Clainche Christophe , Cardoso Dos Santos Marcelina 
Published: July 2024

AbstractUnderstanding the mechanisms of assembly and disassembly of macromolecular structures in cells relies on solving biomolecular interactions. However, those interactions often remain unclear because tools to track molecular dynamics are not sufficiently resolved in time or space. In this study, we present a straightforward method for resolving inter‐ and intra‐molecular interactions in cell adhesive machinery, using quantum dot (QD) based Förster resonance energy transfer (FRET) nanosensors. Using a mechanosensitive protein, talin, one of the major components of focal adhesions, we are investigating the mechanosensing ability of proteins to sense and respond to mechanical stimuli. First, we quantified the distances separating talin and a giant unilamellar vesicle membrane for three talin variants. These variants differ in molecular length. Second, we investigated the mechanosensing capabilities of talin, i.e., its conformational changes due to mechanical stretching initiated by cytoskeleton contraction. Our results suggest that in early focal adhesion, talin undergoes stretching, corresponding to a decrease in the talin‐membrane distance of 2.5 nm. We demonstrate that QD‐FRET nanosensors can be applied for the sensitive quantification of mechanosensing with a sub‐nanometer accuracy.
Enhancing Efficiency and Durability of Perovskite Solar Cells With Chlorine‐Functionalized Fully Conjugated Porous Aromatic Framework
Authors: Jing Yege , Wang Chen , Zhu Bo , Xiao Songwen , Guan Wei , Liu Shuainan , Zhang Ning , Wen Shanpeng , Zhu Guangshan 
Published: July 2024

AbstractNon‐radiative recombination, caused by trap states, significantly hampers the efficiency and stability of perovskite solar cells (PSCs). The emerging porous organic polymers (POPs) show promise as a platform for designing novel defect passivation agents due to their rigid and porous structure. However, the POPs reported so far lack either sufficient stability or clear sites of interactions with the defects. Herein, two chlorine‐functionalized, fully conjugated porous aromatic frameworks (PAFs) were constructed via a decarbonylation reaction. The chlorinated PAFs feature unique long‐range conjugated networks bearing multiple chlorine atoms, significantly improving the photovoltaic performance and stability of doped solar cells. Combined experimental and theoretical analyses confirmed the strong passivation effects of conjugated structure to the defect through Cl sites. Specifically, PAF‐159, bearing a triphenylamine moiety, demonstrated stronger Cl−Pb bonding and higher passivation efficiency due to the presence of π* anti‐bonding orbitals, which elevate the HOMO energy level and facilitate Cl−Pb charge transfer. Consequently, we obtained high‐performance PAF‐159‐doped devices with advanced PCE (24.3 %), good storage stability (retaining 86 % after 3000 hours), and good long‐term operational stability (retaining 92 % after 350 hours).
Palladium‐Catalyzed Enantioselective Migratory Hydroamidocarbonylation of Amide‐Linked Alkenes to Access Chiral α‐Alkyl Succinimides
Authors: Wang Zhen , Shen Chaoren , Dong Kaiwu 
Published: July 2024

AbstractA Pd‐catalyzed asymmetric isomerization‐hydroamidocarbonylation of amide‐containing alkenes was developed, affording a variety of chiral α‐alkyl succinimides in moderate to good yields with high enantioselectivities. The key to success was introducing bulky 1‐adamentyl P‐substitution and 2,3,5,6‐tetramethoxyphenyl group into the rigid P‐chirogenic bisphosphine ligand to create stronger steric hinderance and deeper catalytic pocket. By this approach, regio‐ or stereo‐convergent synthesis of enantiomeric succinimides from the mixture of olefin isomers was achieved.
Enhancing the catalytic performance of Cu/ZnO/Al2O3 catalyst in methanol synthesis from biomass‐derived syngas with CeO2, MnO2 and ZrO2 as promoters
Authors: Simanungkalit Sabar Pangihutan , Okoye Chiemeka Onyeka , Zhang Zhezi , Wu Junzhi , Zhang Dongke 
Published: July 2024

AbstractThe performance of Cu/ZnO/Al2O3 (CZA) catalysts promoted by addition of CeO2, MnO2 or ZrO2 in direct methanol production from unconventional syngas was experimentally investigated. The unconventional syngas used in this study contain 25% H2, 25% CO, 20% CH4, 20% CO2 and 10% N2, representing biomass‐derived syngas cultivated from an industrial wood chips pyrolysis plant. The catalysts were synthesised using co‐precipitation technique and tested for methanol synthesis in a fixed‐bed reactor. The activity test of the catalysts showed that the addition of CeO2 or ZrO2 to the CZA catalyst improved the methanol yield, albeit with lower selectivity, whereas adding MnO2 enhanced methanol selectivity but decreased the methanol yield. ZrO2‐promoted catalyst showed the best‐improved activity and stability. The calcined and spent catalysts were characterised using X‐ray diffraction (XRD), N2 physisorption, N2O chemisorption, hydrogen temperature‐programmed reduction (H2‐TPR) and X‐ray photoelectron spectroscopy (XPS). The characterisation results indicate that the catalytic activity is dependent on Cu dispersion, Cu‐active surface area, the catalyst reducibility, Brunauer–Emmett–Teller (BET) surface area and the Cu0/Cu+ ratio. In contrast, catalyst stability was related to the proportion of Cu+ among all surface Cu species.
Covalently attached phosphonic acid‐Si2O3‐PEO polymer membranes for PEMFC applications
Authors: Gilbert Patrick , Stankovic Jovan , Galaffu Nico , Abrahams Isaac , Sullivan Alice C. 
Published: July 2024

AbstractIn the context of growing interest in phosphonic acid proton exchange membranes (PEMs) for fuel cell applications, we report on new PEMs containing low‐cost polyethylene oxide (PEO) covalently linked by siloxane bonds, SiOSi, to phosphonic acid (PA). Key chemistry in the formation of these membranes involves hydrolysis and condensation reactions of triethoxysilyl propyl capped PEO and pre‐hydrolyzed dimethyl phosphonatoethyltrimethoxysilane (DMPTMS) giving PEO‐Si2O3‐PA and cross‐linked chain PEO‐Si2O3‐PEO organosilsesquioxane components. The Si2O3 can enhance membrane thermal and mechanical properties. The membrane formulations were varied by (a) reagent ratios (b) PEO molecular weights or using polypropylene oxide (PPO) (c) incorporating chain extending groups methylene diphenyl diisocyanate (MDI) or hexamethylene diisocyanate (HDI). These variations provided five membrane families, one of which afforded a complete group of robust membranes with weight% x of PA, PAx in range PA0–PA33. These were studied using ATR‐FTIR, dry membrane water uptake capacity, ion exchange capacity (IEC), and conductivity from room temperature to 120°C at 100% relative humidity. Conductivity increased with PAx reaching 15 mS cm−1 at 120°C, activation energy 0.1 eV, for membrane PA33 for which thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and energy dispersive X‐ray analysis (EDAX) are reported. A comparative performance of the five membrane families is presented.
Application of Cyrene solvent for the fabrication of polymethyl methacrylate, polyethyl methacrylate and composite films containing hydroxyapatite and diamonds
Authors: Wang ZhengZheng , Zhitomirsky Igor 
Published: July 2024

AbstractCyrene is a new biodegradable solvent, which represents a green alternative to many traditional toxic solvents for advanced polymers. Therefore, this investigation is motivated by interest in applications of Cyrene for polymer processing. The feasibility of solubilization of polymethyl methacrylate (PMMA) and polyethyl methacrylate (PEMA) in Cyrene is demonstrated. The ability to form relatively concentrated solutions of the high molecular mass polymers is an important factor for the formation of PMMA and PEMA films by a dip coating method. It was found that the polymer coatings provide corrosion protection of stainless steel in 30 g L−1 NaCl solutions. Another important finding is that the use of Cyrene facilitates the fabrication of stable suspensions of hydroxyapatite (HAp), microdiamond, and nanodiamond particles. Therefore, the problems of the dispersant selection for dispersion of chemically inert diamond and development of biocompatible dispersants are avoided using Cyrene. For the fabrication of composite films, HAp nanorods with reduced particle size are obtained using rutin as a chelating capping agent. Composite films containing HAp, microdiamond and nanodiamond in the PMMA or PEMA matrix are obtained. The composite films are promising for biomedical applications. It was found that the film morphology, composition and microstructure are influenced by the solvent–particle–polymer interactions and processing conditions.
Electrolyte Design for Low Temperature Lithium‐Sulfur Battery: From Different Polysulfide Conversion Mechanisms
Authors: Chen Ying , Wang Bao , Zhang Zhuangzhuang , Huang Yudai , Li Bao 
Published: July 2024

AbstractWith the increasing demand for large‐scale energy storage devices, lithium‐sulfur (Li−S) batteries have emerged as a promising candidate because of their ultrahigh energy density (2600 Wh Kg−1) and the cost‐effectiveness of sulfur cathodes. However, the notorious shuttle effect derived from lithium polysulfide species (LiPSs) hampers their practical application, especially at low temperature. Therefore, electrolytes with low viscosity and high conductivity are required with the advancement of next‐generation Li−S batteries. Understanding the interface structure dependent solvent electrochemistry and recognizing the existing issues relating to electrolytes are indispensable prerequisites. This review briefly summarizes the challenges to further develop the new generation of Li−S batteries, which can operate steadily at subzero temperature, including LiPSs accumulation, Li2S nucleation, lithium deposition, and so on. On the basis of the crucial role of electrolytes in solving these questions, we outline the corresponding electrolyte design strategies from the different mechanisms (solid‐liquid‐solid conversion, all‐solid‐phase conversion, and all‐liquid‐phase conversion) such as lithium salt modification, additive introduction, and introduction of strong cationic electrolytes, as well as the application of solid‐state electrolytes, and so on. Finally, we emphasize promising strategies and solutions to improve low‐temperature performance, pointing the way for the future development of maximizing extreme‐temperature electrolytes toward practical applications.
Dual benefits of NBD‐Cl fluorogenic action and sample pretreatment (SALLE) technology in the assessment of anticoagulant medication: Dabigatran in pharmaceutical capsules and plasma samples
Authors: El Hamd Mohamed A. , Mahdi Wael A. , Alshehri Sultan , Abu‐hassan Ahmed A. 
Published: July 2024

AbstractDabigatran (DBG), marketed as Pradaxa, is an anticoagulant medication prescribed for the treatment and mitigation of blood clots and to lower the risk of stroke in individuals with the heart condition known as atrial fibrillation. This medication is specifically indicated for preventing blood clots post hip or knee replacement surgeries and in patients with a prior history of clots. Compared to warfarin, dabigatran serves as a viable alternative that does not necessitate routine blood monitoring tests. The complimentary benefits associated with SALL (salting‐out assisted liquid–liquid extraction) and the fluorogenic capabilities of benzofurazan. These methods were combined to provide an affordable and sensitive DBG assaying method. The spectral strength of the yellow luminous product was examined at 533.8 nm and by adjustment of a wavelength of 474.7 nm for excitation. To assess its linearity, the calibration chart was tested across a DBG concentration range of 30–500 ng/ml. Via accurate computation based on ICH, the detection limit (LD) was determined to be 9.5 ng/ml, and the strategy can quantify the DBG to a limit of 28 ng/ml. To ensure success, various crucial parameters for method implementation have been extensively studied and adapted. The validation of the strategy adhered to the policies outlined by ICH, affirming its precision in quantifying DBG in capsules. Furthermore, the inclusion of SALLE steps facilitated accurate monitoring of DBG in plasma samples, introducing a unique and advanced methodology for analyzing this compound in biological samples.
A new fabricated hetero‐atom doped carbon quantum dots as a fluorescent probe for metronidazole determination using garlic and red lentils with microwave assistance
Authors: El‐Semary Mariam S. , Belal Fathalla , El‐Emam Ali A. , El‐Shaheny Rania N. , El‐Masry Amal A. 
Published: July 2024

AbstractBiocompatible and highly fluorescent phosphorus, nitrogen and sulfur carbon quantum dots (P,N,S‐CQDs) were synthesized using a quick and ecologically friendly process inspired from plant sources. Garlic and red lentils were utilized as natural and inexpensive sources for efficient synthesis of the carbon‐based quantum dots using green microwave‐irradiation, which provides an ultrafast route for carbonization of the organic biomass and subsequent fabrication of P,N,S‐CQDs within only 3 min. The formed P,N,S‐CQDs showed excellent blue fluorescence at λem = 412 nm when excited at 325 nm with a quantum yield up to 26.4%. These fluorescent dots were used as a nano‐sensor for the determination of the commonly used antibacterial and antiprotozoal drug, metronidazole (MTR). As MTR lacked native fluorescence and prior published techniques had several limitations, the proposed methodology became increasingly relevant. This approach affords sensitive detection with a wide linear range of 0.5–100.0 μM and LOD and LOQ values of 0.14 μM and 0.42 μM, respectively. As well as, it is cost‐effective and ecologically benign. The MTT test was used to evaluate the in‐vitro cytotoxicity of the fabricated P,N,S‐CQDs. The findings supported a minimally cytotoxic impact and good biocompatibility, which provide a future perspective for the applicability of these CQDs in biomedical applications.