bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut Microbial Metabolites of Polyunsaturated Fatty Acids Correlate with Specific Fecal Bacteria and Serum Markers of Metabolic Syndrome in Obese Women
Authors: Druart Céline , Dewulf Evelyne M. , Cani Patrice D. , Neyrinck Audrey M. , Thissen Jean‐Paul , Delzenne Nathalie M. 
Published: January 2014

AbstractThe aim of this human study was to assess the influence of prebiotic‐induced gut microbiota modulation on PUFA‐derived bacterial metabolites production. Therefore, we analyzed the circulating fatty acid profile including CLA/CLnA in obese women treated during 3 months with inulin‐type fructan prebiotics. In these patients, we had already determined gut microbiota composition by phylogenetic microarray and qPCR analysis of 16S rDNA. Some PUFA‐derived bacterial metabolites were detected in the serum of obese patients. Despite the prebiotic‐induced modulation of gut microbiota, including changes in CLA/CLnA‐producing bacteria, the treatment did not impact significantly on the circulating level of these metabolites. However, some PUFA‐derived bacterial metabolites were positively correlated with specific fecal bacteria (Bifidobacterium spp., Eubacterium ventriosum and Lactobacillus spp.) and inversely correlated with serum cholesterol (total, LDL, HDL). These correlations suggest a potential beneficial effect of some of these metabolites but this remains to be confirmed by further investigation.
The Multidimensional Structure of Subjective Well-Being In Later Life
Authors: Vanhoutte Bram 
Published: January 2014

Abstract
Subjective well-being can be measured in different ways, depending on the conceptual perspective one adopts. Hedonic well-being, emphasising emotions and evaluation, is often contrasted with eudemonic well-being, stressing self-actualisation and autonomy. In this paper we investigate the background, structure and compatibility of empirical measures of hedonic and eudemonic well-being in the English Longitudinal Study of Ageing (ELSA). We use a confirmatory factor approach to investigate the internal of structure of the General Health Questionnaire (GHQ), Centre for Epidemiological Studies Depression scale (CES-D), Satisfaction with Life scale (SWLS) and CASP, a measure of quality of life in old age. In a second step, we examine the higher order structure of well-being using these measures. Next to highlighting specific issues about the structure of these measures in connection to older populations, we illustrate that a threefold structure, distinguishing affective, cognitive and eudemonic aspects of well-being, is more informative than the two dimensional hedonic and eudemonic well-being that is often propagated.
Middle Paleozoic basaltic and kimberlitic magmatism in the northwestern shoulder of the Vilyui Rift, Siberia: relations in space and time
Authors: Kiselev A.I. , Yarmolyuk V.V. , Ivanov A.V. , Egorov K.N. 
Published: January 2014

Abstract
A Middle Paleozoic tectonothermal event in the eastern Siberian craton was especially active in the area of the Vilyui rift, where it produced a system of rift basins filled with Devonian–Early Carboniferous volcanics and sediments, as well as long swarms of mafic dikes on the rift shoulders. Basalts occur mostly among Middle Devonian sediments and are much less spread in Early Carboniferous formations. The dolerite dikes of the Vilyui–Markha swarm in the northwestern rift border coexist with the Mirnyi and Nakyn fields of diamond-bearing kimberlites. The voluminous dikes and sills intruded before the emplacement of kimberlites. The Mir kimberlite crosscuts a dolerite sill and a dike in the Mirnyi field, while a complex dolerite dike (monzonite porphyry) cuts through the Nyurba kimberlite in the Nakyn field. Thus, the kimberlites correspond to a longer span of Middle Paleozoic basaltic magmatism. The basalts in Middle Paleozoic sediments have faunal age constraints, but the age of dolerite dikes remains uncertain. The monzonite porphyry dike in the Nyurba kimberlite has been dated by the 40Ar/39Ar method, and the obtained age must be the upper bound of the dike emplacement. The space and time relations between basaltic and kimberlitic magmatism were controlled by Devonian plume–lithosphere interaction.
Noble-metal ore genesis and mantle–crust interaction
Authors: Goryachev N.A. 
Published: January 2014

Abstract
The mineral and geochemical compositions of noble-metal (first of all, gold) deposits of the Fennoscandian, Siberian, and Northeast Asian orogenic belts are considered. These deposits are of several types: Au (disseminated Au–sulfide and Au–quartz), Au–Bi, Au–Ag, Au–Sb, Ag–Sb, Au–Sb–Hg, and Ag–Hg. They formed in different geodynamic settings as a result of the active motion of crustal tectonic blocks of different nature. Subduction processes (both at the front and at the rear of continent-marginal and island-arc magmatic arcs) resulted in Au–Ag, Ag–Sb, Ag–Hg, Au–Sb–Hg, and Au–Bi deposits. Collision events gave rise to Au and Au–Bi deposits. Intraplate continental rifting and formation of orogenic belts along the boundaries of block (plate) sliding led to the origin of Au and Au–Bi ores in association with Au–Ag, Au–Sb–Hg, and complex ores. In all cases, the formation of noble-metal mineralization was accompanied by magmatism of different types and metamorphism. Because of this diversity of ores, there is no single concept of the genesis of noble-metal mineralization. Several competing models of genesis exist: hydrothermal-metamorphic, pluton-metamorphic, plutonic, activity of mantle fluid flows, and multistage concentration during the crust–mantle interaction with the leading role of sedimentary complexes.
Bovine lactoferrin ingestion protects against inflammation via IL-11 induction in the small intestine of mice with hepatitis
Authors: Kuhara Tetsuya , Tanaka Azusa , Yamauchi Koji , Iwatsuki Keiji 
Published: January 2014

Accumulating evidence suggests that orally ingested lactoferrin protects against inflammation. To assess the efficacy of orally administered bovine lactoferrin (bLF) against hepatitis and to identify the underlying mechanism, in the present study, we used four mouse models of hepatitis induced byd-galactosamine (GalN), carbon tetrachloride (CCl4), GalN plus lipopolysaccharide (LPS) and zymosan plus LPS. Intraperitoneal (i.p.) injection of GalN (500 mg/kg body weight) in mice treated with bovine serum albumin (BSA) for 14 d significantly increased serum aspartate aminotransferase (AST) concentrations compared with the untreated mice. However, orally administered bLF reduced AST concentrations compared with BSA treatment. In mice that received a single injection (0·4 ml/kg) and twice-weekly injections (0·08 ml/kg) of CCl4for 24 weeks and pretreated with bLF for 14 d and 24 weeks, respectively, significantly suppressed alanine aminotransferase and AST concentrations were observed compared with the BSA-treated control. Oral administration of bLF for 14 d before i.p. injection of LPS (5 mg/kg) plus GalN (1 g/kg) significantly improved the survival rate. In mice that received intravenous injection of zymosan (25 mg/kg) and LPS (15 μg/kg) at 7 d intervals, bLF reduced the elevation of AST concentrations and enhanced the production of IL-11 and bone morphogenetic protein 2 in the small intestine compared with the BSA-treated control. To evaluate the effects of IL-11, we used IL-11 receptor α-null mice treated with GalN, CCl4and zymosan plus LPS. In this group, the activity of bLF was not significantly different from that of BSA. These data indicate that orally ingested bLF enhances the expression of IL-11 in the small intestine and up-regulates protective activity in mice with hepatitis.
Exome analysis resolves differential diagnosis of familial kidney disease and uncovers a potential confounding variant
Authors: GIBSON JANE , GILBERT RODNEY D. , BUNYAN DAVID J. , ANGUS ELIZABETH M. , FOWLER DARREN J. , ENNIS SARAH 
Published: January 2014

SummaryA girl aged 6 presented with haematuria and her sister (aged 5) presented with haematuria and proteinuria. Family history showed multiple individuals suffering from end stage renal failure from the paternal side of the pedigree. Following kidney biopsy in the father and paternal grandmother, the pathological diagnosis was of focal segmental glomerulosclerosis (FSGS). Exome sequencing was undertaken in the proband's sister and grandmother. Genetic variants shared by both affected individuals were interrogated to identify the genetic cause of disease. Candidate variants were then sequenced in all the family members to determine segregation with the disease. A mutation of COL4A5 known to cause Alport syndrome segregated with disease from the paternal side of the pedigree and a variant in NPHS1 was present in both paediatric cases and inherited from their mother. This study highlights the advantages of exome sequencing over single gene testing; disease presentation can be heterogeneous with several genes representing plausible candidates; candidate gene(s) may be unavailable as a diagnostic test; consecutive, single gene testing typically concludes once a single causal mutation is identified. In this family, we were able to confirm a diagnosis of Alport syndrome, which will facilitate testing in other family members.
Canton and Nagasaki Compared in the Context of Global and World History
Authors: Masashi Haneda 
Published: January 2014

In December 2007, our Chinese and Dutch colleagues organised an international conference in Guangzhou and Macao entitled “Canton and Nagasaki Compared, 1730–1830: Dutch, Chinese, Japanese Relations.” I participated with seven Japanese colleagues. With more than twenty-five papers, the conference was a great success and participants were eager to deepen their discussions and to enlarge the scope of their inquiries. And so, stimulated by the co-editor of this special issue of Itinerario, Professor Leonard Blussé of Leiden University, I took up the responsibility of organising the follow-up conference in Japan on the same theme, but placed in a broader temporal context: “Canton and Nagasaki Compared.” Comparing the two port cities Canton in South China (nowadays called Guangzhou) and Nagasaki at the western end of the Japanese archipelago, between 1600 and 1850 would yield new historic insights and reveal new perspectives for further research. The articles presented in this issue bear the fruit of this exclusive intellectual exchange.The articles deal with wide ranging subjects, from urban fires to the art of translation, and cover the broad period 1600–1850s. All contributors have taken the comparison of the two port cities at heart. We have grouped the thirteen contributions along four major research themes that emerged out of the conference: shipping networks and the state; managing trade flows; mediating trade; and urban and cultural life. The contributions bear witness of what I would call the four major benefits of the comparative history approach, which will be discussed further below.
“The Border of Japan” for Chinese Arrivals in Nagasaki, Satsuma, and Ryukyu
Authors: Miki Watanabe 
Published: January 2014

When entering a foreign country, one usually fills out an immigration form asking for a set of personal details such as one's name, nationality, date of departure, destination, and the purpose of one's visit. In addition, one needs to answer several questions, for example, whether he has any banned substances or objects like drugs or weapons, whether he have a criminal record, and so on. Furthermore, one has to waive any rights to appeal an immigration officer's decision and finally declare and sign that all answers are true and correct.While many assume that this familiar system is specific to the modern age, historical documents show us that this supposition is not valid. In fact, we can find a similar system in the early modern Ryukyu Kingdom, though little attention has been paid to it. To demonstrate this system, I will begin introducing a document left by a shipwrecked Chinese captain coming to Ryukyu in the late eighteenth century:The captain Li Zhenchun states that: We received a permit for sailing from the government of Min prefecture in Fujian on December 24, 1770, loaded wood under the Nantai bridge on May 13 in the next year, sailed from Min'anzhen for Shandong on May 24, and arrived on June 24. Though we left for Fujian on December 2, after purchasing beans, on the next day, a storm broke our mast and halyards, which made it impossible for us to navigate and caused our ship to drift into Yaeyama Island in your country on the 22nd. Now we are living on board here. There is no Christian missionary, arsenic, Epicanta gorhami [, which is a terribly virulent insect including cantharis], or any other poison with us. None of us are disguised as Chinese people clothed in Chinese clothes. Also we have no weapons. If you find any violation as such, we should be tried by the national laws. There is no lie in this report.
Research Statement: Portuguese–Dutch Conflicts and the Macao–Nagasaki Trade in the Early Seventeenth Century
Authors: Shaoxin Dong 
Published: January 2014

The Macao–Nagasaki connection in the early seventeenth century involved a complex set of interrelationships with regard to trade, mission, cultural intercourse, and other important topics between China, Japan, Portugal, Spain, and the Netherlands. The rise to importance of Macao and Nagasaki was the result of the interruption of Sino–Japanese trade relations and the policy adjustments by the governments of China and Japan to bring the Portuguese under their control and administration. One of the main differences between Macao and Nagasaki was that the former remained a Portuguese settlement for centuries, while the latter was an enclave first of the Portuguese and later of the Dutch. This short article, mainly based on secondary sources by C. R. Boxer, Leonard Blussé, and others, is a tentative study of the international relations in East Asia and their changes after the appearance of the Portuguese and the Dutch in the late sixteenth and early seventeenth centuries.Two important facts make the sixteen-century international relations in East Asia different from the situation before: the appearance of the Portuguese in this area and the deterioration of Sino–Japanese relations.For the first thirty years after the Portuguese arrived on the coast of Guangdong in 1514, encounters between them and the Chinese were rife with misunderstandings and conflicts, because Portugal was not a tributary country of China; the Portuguese were totally new to the Chinese. As the Portuguese could not establish formal commercial relations with China, in order to acquire Chinese goods they sought close relations with Chinese and later Japanese smugglers and pirates. They even engaged in the slave trade, which gave them a very bad name in China.
The Privileges of Working with the VOC: Supplementary Incomes of the Interpreters in Nagasaki and Canton
Authors: Tanaka-Van Daalen Isabel 
Published: January 2014

In order to “describe world history from a new angle,” Professor Haneda Masashi has set up the framework of “Comparative Studies on the Cross-cultural Contacts in Asian Port Cities in the Seventeenth and Eighteenth Centuries.” One of the proposed points of comparison concerned communications between Europeans and local people and the indispensable role of interpreters, on whose work “the Dutch trade representatives relied utterly in their business and daily life” in Canton as well as Nagasaki.Whereas Professor Yao Keisuke, elsewhere in this special issue, has emphasised the different roles of the interpreters in both port cities, Professor Haneda is more in favour of pointing out the similarities. He has identified state control of foreign trade, motivated by concerns over “security, social stability, and the prosperity of the state,” as a fundamental feature common to both countries in this period. Because of a clear distinction between the local people as “insiders” and Europeans as “outsiders,” the foreigners' activities were strictly controlled and contacts between locals and Westerners restricted to a minimum. The interpreters stood between both parties as mediators and were intentionally used by the authorities as “tools of control,” sometimes functioning as spies reporting on suspicious activities, but also acting as safety shields against direct Dutch confrontations or breaches of etiquette and protocol. Mechanisms to control the interpreters themselves were built in as well.
Daily Life of the Dutch in Canton and Nagasaki: A Comparison Based on the VOC Dagregisters and Other Sources
Authors: Viallé Cynthia 
Published: January 2014

These few words were entered from time to time in the dagregisters, the official diaries kept by the heads of the Dutch East India Company trade in Canton and Nagasaki during their stay there. Fortunately, they do not occur too often, otherwise we would know far less about the lives and circumstances of the Dutch in China and Japan than we do. As it is, the dagregisters provide us with a wealth of information on a wide range of topics ranging from commercial matters, social and trade relations between Europeans and East Asians, political matters, the importation and use of Western technology and medicine in Japan, natural disasters, crimes, and, very important, the weather. The entries in the dagregisters recorded what happened on the day and they give us descriptions, sometimes in great detail, of the activities of the Dutch and their fellow Europeans in Canton and Nagasaki and of their interactions with their Chinese and Japanese hosts. They are the best sources for an understanding of the patterns of everyday life of the Dutchmen in the foreign settlements in the port cities of Canton and Nagasaki.The instruction to keep dagregisters (diaries) dates back as far as 1621, when the Heren Zeventien (the Gentlemen Seventeen, the board of governors of the Dutch East India Company in the Netherlands) wrote to the governor-general and councillors of the Indies in Batavia (present-day Jakarta), the VOC headquarters in Asia: “We think it necessary that not only in the General Comptoir [Office] in Batavia, but also in those in the Moluccas, Amboina, Banda, Patani, Japan, Jambi, Paliacatta, and Surat, in sum, in all those places where we have offices, our people keep a daily journal of everything that happens there and concerns our people, both in regard to the English, as to any other people, whoever it may be, in any way.
Salient values, social trust, and attitudes toward wolf management in south-western Alberta, Canada
Authors: SPONARSKI CARLY C. , VASKE JERRY J. , BATH ALISTAIR J , MUSIANI MARCO M. 
Published: January 2014

SUMMARYShared values, public trust in an agency, and attitudes can influence support for successful conservation initiatives. To understand these relationships, this paper examines the role of social trust as a partial mediator between salient values similarity and attitudes toward wolves in south-western Alberta, Canada. Rural residents in this area face increasing wolf depredation on livestock. Data were obtained from a mail questionnaire (n= 566 respondents, response rate = 70%) sent to rural residents in three municipal districts in south-western Alberta. Attitudes were predicted to directly influence behavioural intention to support or oppose wolf management. Most respondents held slightly similar values as the management agency and minimally trusted the agency to effectively manage wolves. As predicted, social trust in the agency served as a partial mediator between salient value similarity and attitudes toward wolves. Salient value similarity was also a strong predictor of attitudes toward wolves. Attitudes toward wolves predicted behavioural support. Thus, social trust of the management agency can influence attitudes and management preferences concerning a species. When dealing with human-wildlife conflict, social trust should be examined to understand the context of the problem.
Birth and adoptive parent anxiety symptoms moderate the link between infant attention control and internalizing problems in toddlerhood
Authors: Brooker Rebecca J. , Neiderhiser Jenae M. , Ganiban Jody M. , Leve Leslie D. , Shaw Daniel S. , Reiss David 
Published: January 2014

AbstractAttention control plays an important role in the development of internalizing symptoms in children. We explored the degree to which infants' genetic and environmentally based risk moderated the link between attention control and internalizing problems during toddlerhood. These associations were examined within a prospective adoption design, enabling the disentanglement of genetic and environmental risk for internalizing problems. Attention control in adopted infants was observed during periods of distress at age 9 months. Birth parents' anxiety symptoms were used as an index of genetic risk, while adoptive parents' anxiety symptoms were used as an index of environmental risk. Adoptive mothers and fathers reported on children's internalizing problems when children were 18 and 27 months old. Greater attention control in infancy appeared to mitigate genetically based risk for internalizing problems during toddlerhood when children were raised by adoptive parents who were low in anxiety. Findings suggest that for genetically susceptible children who are raised in low-risk environments, attention control may provide a protective factor against developing internalizing problems across early life.
The “Polar Light Sign” is a useful tool to detect discrete membranous supravalvular mitral stenosis
Authors: Hertwig Christine , Haas Nikolaus A. , Habash Sheeraz , Hanslik Andreas , Kececioglu Deniz , Sandica Eugen , Laser Kai-Thorsten 
Published: January 2014

AbstractMitral valve stenosis caused by a discrete supravalvular membrane is a rare congenital malformation haemodynamically leading to significant mitral valve stenosis. When the supravalvular mitral stenosis consists of a discrete supravalvular membrane adherent to the mitral valve, it is usually not clearly detectable by routine echocardiography. We report about the typical echocardiographic finding in three young patients with this rare form of a discrete membranous supravalvular stenosis caused by a membrane adherent to the mitral valve. These cases present a typical echocardiographic feature in colour Doppler generated by the pathognomonic supramitral flow acceleration. Whereas typical supravalvular mitral stenosis caused by cor triatriatum or a clearly visible supravalvular ring is easily detectable by echocardiography, a discrete supravalvular membrane adjacent to the mitral valve leaflets resembling valvular mitral stenosis is difficult to differentiate by routine echocardiography. In our opinion, this colour phenomenon does resemble the visual impression of polar lights in the northern hemisphere; owing to its typical appearance, it may therefore be named as “Polar Light Sign”. This phenomenon may help to detect this anatomical entity by echocardiography in time and therefore improve the prognosis for repair.