bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleeve lobectomy versus pneumonectomy following neoadjuvant therapy in patients with non-small cell lung cancer
Authors: Teng Meixin , Yi Chengxiang , Yang Weiguang , Zhang Jing , Yao Wangchao , Hu Shiqi , Qing Yang , Ji Shuyu , Shen Ziyun , Zhang Peng 
Published: August 2024

Abstract

OBJECTIVES
Neoadjuvant therapy has gained widespread acceptance as the standard modality for locally advanced non-small cell lung cancer. However, the clinical benefit of sleeve lobectomy (SL) or pneumonectomy (PN) following neoadjuvant therapy remains controversial.

METHODS
The clinical and pathological characteristics of non-small cell lung cancer patients who underwent SL or PN after neoadjuvant therapy at a high-volume single centre between December 2019 and March 2023 were retrospectively collected. The SL group was matched 4:1 with the PN group by propensity score matching. The surgical outcomes were systematically collected and analysed.

RESULTS
During a 5-year study period, the majority of patients (175 of 215, 81.4%) underwent the SL procedure, while 40 patients (18.6%) underwent PN. Following propensity score matching, the SL group exhibited lower postoperative arrythmia (4.8% vs 26.9%, P &lt; 0.001), lower 30-day mortality (1.0% vs 7.7%, P = 0.046) and a shorter length of postoperative hospital stay (6.0 days vs 10.0 days, P &lt; 0.001), compared with the PN group. In addition, no significant difference was observed between the two groups in terms of disease-free survival or overall survival (P = 0.977 and P = 0.913, respectively).

CONCLUSIONS
SL stands as a safe and feasible option for patients with centrally located non-small-cell lung cancer who have undergone neoadjuvant therapy, in comparison to PN. This finding suggests that SL remains the preferable choice when feasible in the context of the widespread utilization of neoadjuvant therapy.
Left ventricular stent-graft implantation for severe left ventricular outflow tract obstruction after transcatheter mitral valve implantation
Authors: Ruge Hendrik , Krane Markus 
Published: August 2024

Abstract
Left ventricular outflow tract obstruction is a rare complication following transcatheter mitral valve implantation. Diagnosing the underlying cause is mandatory to select from different treatment options. We report a case of stent-graft implantation into the left ventricular outflow tract for dynamic left ventricular outflow tract obstruction caused by systolic anterior motion of the anterior mitral valve leaflet (SAM).
The effect of early childhood non-nutritive sucking behavior including pacifiers on malocclusion: a randomized controlled trial
Authors: Arpalahti Irma , Hänninen Krista , Tolvanen Mimmi , Varrela Juha , Rice David P 
Published: August 2024

Abstract

Background/rationale
Systematic reviews on the effects of pacifiers on occlusion have highlighted the need for quality RCTs.

Trial design
Single region, three parallel-armed, prospective, randomized controlled trial.

Objectives
To investigate the correlations between early childhood non-nutritive sucking habits and malocclusion. Specifically to test whether the use of a study pacifier has differing effects compared to other pacifiers and control, and whether the duration of pacifier use or digit sucking influence the occlusion.

Participants
The subjects were firstborn children, born in 2008 in Vantaa, Finland.

Intervention
One-third of participants were offered study pacifiers, free of charge, from birth up to 2 years of age. The history of the subjects’ sucking habits, including pacifier use was screened in a questionnaire at the age of 2 years, and clinical examinations were performed at the age of 7 years. In addition, the subjects were divided into groups that were equally matched regarding their mother’s level of education.

Outcomes
Posterior crossbite, anterior crossbite, overjet, deep bite, open bite, and crowding.

Randomization method
Three districts were randomly allocated to three study groups by drawing lots.

Blinding
It was not possible to blind the clinicians or parents from the intervention. Blinding during data analysis was performed.

Results
From the original cohort of 2715 children born in the town of Vantaa, 1911 were excluded and 353 were lost to follow-up. The remaining 451 children were divided into three groups according to the use of pacifiers. The prevalence of posterior crossbite at the age of 7 years was higher if a non-study pacifier had been used (P = .005) even when matched for the mother’s level of education (P = .029). The prevalence of posterior crossbite was higher if the pacifier habit had continued for 12 months or more compared to 11 months or less, 7% and 1%, respectively, (P = .003). Digit sucking for 12 months or more was associated with crowding (P = .016). The prevalence of crossbite in the study pacifier group was less than in control pacifiers.

Harms
No adverse harms were reported other than effects on the dentition.

Conclusion
The use of pacifiers is associated with the posterior crossbite, especially if their use continues for a year or more. Parents/guardians should be advised to stop the use or reduce the use of pacifiers to a minimum after their child’s first birthday.

Trial registration
ClinicalTrials.gov NCT01854502.
Blood pressure response to graded bicycle exercise in males and females across the age and fitness spectrum
Authors: Janssens Kristel , Foulkes Stephen J , Mitchell Amy M , Dausin Christophe , Van Soest Sofie , Spencer Luke , Rowe Stephanie J , D’Ambrosio Paolo , Elliott Adrian D , Van Puyvelde Tim , Parr Evelyn B , Willems Rik , Heidbuchel Hein , Claessen Guido , La Gerche Andre 
Published: August 2024

Abstract

Aims
Blood pressure (BP) responses to exercise are frequently measured, with the concern that greater increases are a marker of disease. We sought to characterize the normal exercise BP response in healthy adults and its relationships with age, sex, and fitness.

Methods and results
Five hundred and eighty-nine participants [median age 46 (interquartile range 24–56) years, 81% male] underwent cardiopulmonary exercise testing with repeated, automated BP measures. An exaggerated maximal systolic BP (SBPmax) was defined from current guidelines as ≥210 mmHg in males and ≥190 mmHg in females. Individual linear regression analyses defined the relationship between BP and workload (W; SBP/W-slope and DBP/W-slope). Participants with or without an exaggerated SBPmax and above- or below-median SBP/W-slope were compared. An exaggerated SBPmax was found in 51% of males and 64% of females and was more prevalent in endurance-trained athletes (males 58%, females 72%, P &lt; 0.001). The mean SBP/W-slope was lower in males (0.24 ± 0.10 mmHg/W) than females (0.27 ± 0.12 mmHg/W, P = 0.031). In both sexes, peak oxygen uptake (VO2peak) was inversely correlated with SBP/W-slope (P &lt; 0.01). Those with an exaggerated SBPmax and below-median SBP/W-slope were 10 years younger and had a 20% higher VO2peak, on average (P &lt; 0.001). A non-exaggerated SBPmax and above-median SBP/W-slope was observed in older individuals with the lowest VO2peak.

Conclusion
In a large cohort of healthy individuals, an exaggerated SBPmax was common and associated with higher fitness. In contrast, higher SBP indexed to W was associated with older age, lower fitness, and female sex. Thus, sex, age, and fitness should be considered when evaluating BP response to exercise.

Registration
Pro@Heart: NCT05164328, ACTRN12618000716268; ProAFHeart: ACTRN12618000711213; Master@Heart: NCT03711539
Exploring modes of microbial interactions with implications for methane cycling
Authors: Brenzinger Kristof , Glatter Timo , Hakobyan Anna , Meima-Franke Marion , Zweers Hans , Liesack Werner , Bodelier Paul L E 
Published: August 2024

Abstract
Methanotrophs are the sole biological sink of methane. Volatile organic compounds (VOCs) produced by heterotrophic bacteria have been demonstrated to be a potential modulating factor of methane consumption. Here, we identify and disentangle the impact of the volatolome of heterotrophic bacteria on the methanotroph activity and proteome, using Methylomonas as model organism. Our study unambiguously shows how methanotrophy can be influenced by other organisms without direct physical contact. This influence is mediated by VOCs (e.g. dimethyl-polysulphides) or/and CO2 emitted during respiration, which can inhibit growth and methane uptake of the methanotroph, while other VOCs had a stimulating effect on methanotroph activity. Depending on whether the methanotroph was exposed to the volatolome of the heterotroph or to CO2, proteomics revealed differential protein expression patterns with the soluble methane monooxygenase being the most affected enzyme. The interaction between methanotrophs and heterotrophs can have strong positive or negative effects on methane consumption, depending on the species interacting with the methanotroph. We identified potential VOCs involved in the inhibition while positive effects may be triggered by CO2 released by heterotrophic respiration. Our experimental proof of methanotroph–heterotroph interactions clearly calls for detailed research into strategies on how to mitigate methane emissions.
Analysis of transcriptional response in haploid and diploid Schizosaccharomyces pombe under genotoxic stress
Authors: Park Joshua M , Forsburg Susan L 
Published: August 2024

Abstract
Whole genome duplications are implicated in genome instability and tumorigenesis. Human and yeast polyploids exhibit increased replication stress and chromosomal instability, both hallmarks of cancer. In this study, we investigate the transcriptional response of Schizosaccharomyces pombe to increased ploidy generally, and in response to treatment with the genotoxin methyl methanesulfonate (MMS). We find that treatment of MMS induces upregulation of genes involved in general response to genotoxins, in addition to cell cycle regulatory genes. Downregulated genes are enriched in transport and sexual reproductive pathways. We find that the diploid response to MMS is muted compared to the haploid response, although the enriched pathways remain largely the same. Overall, our data suggests that the global S. pombe transcriptome doubles in response to increased ploidy but undergoes modest transcriptional changes in both unperturbed and genotoxic stress conditions.
Reduction of ribosomal expansion segments in yeast species of the Magnusiomyces/Saprochaete clade
Authors: Brázdovič Filip , Brejová Broňa , Siváková Barbara , Baráth Peter , Kerák Filip , Hodorová Viktória , Vinař Tomáš , Tomáška Ľubomír , Nosek Jozef 
Published: August 2024

Abstract
Ribosomes are ribonucleoprotein complexes highly conserved across all domains of life. The size differences of ribosomal RNAs (rRNAs) can be mainly attributed to variable regions termed expansion segments (ESs) protruding out from the ribosomal surface. The ESs were found to be involved in a range of processes including ribosome biogenesis and maturation, translation, and co-translational protein modification. Here, we analyze the rRNAs of the yeasts from the Magnusiomyces/Saprochaete clade belonging to the basal lineages of the subphylum Saccharomycotina. We find that these yeasts are missing more than 400 nt from the 25S rRNA and 150 nt from the 18S rRNAs when compared to their canonical counterparts in Saccharomyces cerevisiae. The missing regions mostly map to ESs, thus representing a shift toward a minimal rRNA structure. Despite the structural changes in rRNAs, we did not identify dramatic alterations of the ribosomal protein inventories. We also show that the size-reduced rRNAs are not limited to the species of the Magnusiomyces/Saprochaete clade, indicating that the shortening of ESs happened independently in several other lineages of the subphylum Saccharomycotina.
Revisiting Martian seismicity with deep learning-based denoising
Authors: Dahmen Nikolaj , Clinton John , Stähler Simon , Meier Men-Andrin , Ceylan Savas , Euchner Fabian , Kim Doyeon , Horleston Anna , Durán Cecilia , Zenhäusern Géraldine , Charalambous Constantinos , Kawamura Taichi , Giardini Domenico 
Published: August 2024

SUMMARY
The analysis of seismic events recorded by NASA’s InSight seismometer remains challenging, given their commonly low magnitudes and large epicentral distances, and concurrently, strongly varying background noise. These factors collectively result in low signal-to-noise ratios (SNR) across most event recordings. We use a deep learning denoising approach to mitigate the noise contamination, aiming to enhance the data analysis and the seismic event catalogue. Our systematic tests demonstrate that denoising performs comparable to fine-tuned bandpass filtering at high SNRs, but clearly outperforms it at low SNRs with respect to accurate waveform and amplitude retrieval, as well as onset picking. We review the denoised waveform data of all 98 low-frequency events in the Marsquake Service catalogue version 14, and improve their location when possible through the identification of phase picks and backazimuths, while ensuring consistency with the raw data. We demonstrate that several event waveforms can be explained by marsquake doublets—two similarly strong quakes in spatio-temporal proximity that result in overlapping waveforms at InSight—and we locate them in Cerberus Fossae (CF). Additionally, we identify and investigate aftershocks and an event sequence consisting of numerous relatively high magnitude marsquakes occurring within hours at epicentral distances beyond CF. As a result of this review and interpretation, we extend the catalogue in event numbers ($+$8 per cent), in events with epicentral distances and magnitudes ($+$50 per cent), and events with backazimuths and a resulting full locations ($+$46 per cent), leading to a more comprehensive description of Martian seismicity.
Populism, Research Integrity, and Trust. How Science-Related Populist Beliefs Shape the Relationship Between Ethical Conduct and Trust in Scientists
Authors: Zillich Arne Freya , Schlütz Daniela , Roehse Eva-Maria , Möhring Wiebke , Link Elena 
Published: August 2024

Abstract
Science-related populism is often used to undermine public trust in science. Good scientific practice contributes to public trust in science, whereas misconduct promotes public skepticism. Since research ethics are a vital part of research integrity, we argue that ethical misconduct potentially undermines trust in scientists, particularly among people with populist beliefs. Drawing on a quota sample of German citizens (N = 1,321), the experimental study examines the influence of ethical conduct on trust in scientists, moderated by science-related populist beliefs. More specifically, we tested the influence of experimental deception (with and without debriefing) using a vignette design. The results of our study showed that ethical misconduct is negatively associated with trust in scientists. In addition, the relationship between ethical misconduct and trust in scientists was influenced by both science-related populist beliefs and science literacy. Although people with high science-related populist beliefs generally placed less trust in scientists, the negative effect was even more pronounced for people with low science-related populist beliefs. Our findings further revealed that ethical misconduct reduces trust in science among people with both low and high science literacy. This demonstrates the importance of researchers transparently discussing and reflecting on ethical research conduct to promote trust in scientists.
Insurance Voting in the Centre: An Experimental Approach
Authors: Fredén Annika , Bruinsma Bastiaan , Theorin Nora , Oscarsson Henrik 
Published: August 2024

Abstract
Recent research suggests that to help their preferred coalition win an election, voters are willing to vote for a political party other than their preferred choice. In this field, voting for smaller parties under proportional representation is an under-studied feature. A crucial factor to estimate the chances for smaller parties is polls. In this study, we analyze the influence of opinion polls on switching vote choice to a smaller party when the party polls are at different levels. Building on an original survey experiment, we elaborate the potential differences in impact on insurance voting for a small party with looser or stronger association with a government alternative. The focus is the 2022 Swedish general election and the three smallest parties in parliament: the Green Party (center-left), the Christian Democrats (right), and the Liberals (center-right). The experiment had nine different conditions where each of these parties was placed at different levels of opinion: below, at, and above the parliamentary threshold, while holding all other factors constant. We find that poll-induced insurance voting is most prevalent for the party with the strongest preference for a government alternative (the Christian Democrats) and least prevalent for the party with a more issue-focused stance (the Greens).
Plasmid-mediated azithromycin resistance in non-typhoidal Salmonella recovered from human infections
Authors: Zhang Xi-Wei , Song Jing-Jie , Zeng Shi-Han , Huang Yu-Lan , Luo Jia-Jun , Guo Wei-Long , Li Xiao-Yan 
Published: August 2024

Abstract

Objectives
Mechanisms of non-typhoidal Salmonella (NTS) resistance to azithromycin have rarely been reported. Here we investigate the epidemiology and genetic features of 10 azithromycin-resistant NTS isolates.

Methods
A total of 457 NTS isolates were collected from a tertiary hospital in Guangzhou. We performed antimicrobial susceptibility tests, conjugation experiments, efflux pump expression tests, whole-genome sequencing and bioinformatics analysis to conduct the study.

Results
The results showed that 10 NTS isolates (2.8%) were resistant to azithromycin with minimum inhibitory concentration values ranging from 128 to 512 mg/L and exhibited multidrug resistance. The phylogenetic tree revealed that 5 S. London isolates (AR1–AR5) recognized at different times and departments were closely related [3–74 single-nucleotide polymorphisms (SNPs)] and 2 S. Typhimurium isolates (AR7 and AR8) were clones (&lt;3 SNPs) at 3-month intervals. The azithromycin resistance was conferred by mph(A) gene found on different plasmids, including IncFIB, IncHI2, InFII, IncC and IncI plasmids. Among them, IncFIB, InFII and IncHI2 plasmids carried different IS26-class 1 integron (intI1) arrangement patterns that mediated multidrug resistance transmission. Conjugative IncC plasmid encoded resistance to ciprofloxacin, ceftriaxone and azithromycin. Furthermore, phylogenetic analysis demonstrated that mph(A)-positive plasmids closely related to 10 plasmids in this study were mainly discovered from NTS, Escherichia coli, Klebsiella pneumonia and Enterobacter hormaechei. The genetic environment of mph(A) in 10 NTS isolates was IS26-mph(A)-mrx(A)-mphR(A)-IS6100/IS26 that co-arranged with intI1 harbour multidrug-resistant (MDR) gene cassettes on diverse plasmids.

Conclusions
These findings highlighted that the dissemination of these plasmids carrying mph(A) and various intI1 MDR gene cassettes would seriously restrict the availability of essential antimicrobial agents for treating NTS infections.
Potential Impact of an Artificial Intelligence–based Mammography Triage Algorithm on Performance and Workload in a Population-based Screening Sample
Authors: Watanabe Alyssa T , Vu Hoanh , Chim Chi Y , Litt Andrew W , Retson Tara , Mayo Ray C 
Published: August 2024

Abstract

Objective
To evaluate potential screening mammography performance and workload impact using a commercial artificial intelligence (AI)–based triage device in a population-based screening sample.

Methods
In this retrospective study, a sample of 2129 women who underwent screening mammograms were evaluated. The performance of a commercial AI-based triage device was compared with radiologists’ reports, actual outcomes, and national benchmarks using commonly used mammography metrics. Up to 5 years of follow-up examination results were evaluated in cases to establish benignity. The algorithm sorted cases into groups of “suspicious” and “low suspicion.” A theoretical workload reduction was calculated by subtracting cases triaged as “low suspicion” from the sample.

Results
At the default 93% sensitivity setting, there was significant improvement (P &lt;.05) in the following triage simulation mean performance measures compared with actual outcome: 45.5% improvement in recall rate (13.4% to 7.3%; 95% CI, 6.2-8.3), 119% improvement in positive predictive value (PPV) 1 (5.3% to 11.6%; 95% CI, 9.96-13.4), 28.5% improvement in PPV2 (24.6% to 31.6%; 95% CI, 24.8-39.1), 20% improvement in sensitivity (83.3% to 100%; 95% CI, 100-100), and 7.2% improvement in specificity (87.2% to 93.5%; 95% CI, 92.4-94.5). A theoretical 62.5% workload reduction was possible. At the ultrahigh 99% sensitivity setting, a theoretical 27% workload reduction was possible. No cancers were missed by the algorithm at either sensitivity.

Conclusion
Artificial intelligence–based triage in this simulation demonstrated potential for significant improvement in mammography performance and predicted substantial theoretical workload reduction without any missed cancers.
Serving with a Smile on Airbnb: Analyzing the Economic Returns and Behavioral Underpinnings of the Host’s Smile
Authors: Zhang Shunyuan , Friedman Elizabeth M S , Srinivasan Kannan , Dhar Ravi , Zhang Xupin 
Published: August 2024

Abstract
Non-informational cues, such as facial expressions, can significantly influence judgments and interpersonal impressions. While past research has explored how smiling affects business outcomes in offline or in-store contexts, relatively less is known about how smiling influences consumer choice in e-commerce settings when there is no face-to-face interaction. In this article, we use a longitudinal Airbnb dataset and a facial attribute classifier to quantify the effect of a smile in the host’s profile photo on property demand and identify factors that influence when a host’s smile is likely to have the biggest effect. A smile in the host’s profile photo increases property demand by 3.5% on average. This effect is moderated by a variety of host and property characteristics that provide evidence for the role of uncertainty underlying why smiling increases demand. Specifically, when there is greater uncertainty regarding either the quality of the accommodations or the interaction with the host, a host’s smile will have a greater effect on demand. Online experiments confirm this pattern, offering further support for uncertainty perceptions driving the effect of smiling on increased Airbnb demand, and show that the effect of smiling on demand generalizes beyond Airbnb.