bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of exergames for cognitive function in older adults with mild cognitive impairment: a systematic review and metaanalysis
Authors: Cai Xiaowan , Xu Liya , Zhang Hanyue , Sun Tingting , Yu Jingjing , Jia Xiao , Hou Xiao , Sun Ruizhe , Pang Jian 
Published: July 2024

PurposeExergames are an innovative method that can promote neuroplasticity and improve the cognitive abilities of the elderly. This study aimed to compare the effects of single-task and multi-task exergames on the cognitive ability of the elderly with mild cognitive impairment (MCI).MethodsComputerized literature search was performed using PubMed, Web of Science, EBSCO, Elsevier, ProQuest, China National Knowledge Infrastructure (CNKI), Wanfang and VIP database to identify relevant articles from the establishment of the database from inception to April 1, 2024. The inclusion criteria were: (i) participants aged 60 or older diagnosed with mild cognitive impairment, regardless of gender; (ii) use of randomized controlled trials (RCTs); (iii) interventions involving exergames with physical activity or as the primary variable; and (iv) outcome measures using standardized neuropsychological instruments to assess cognitive function, including statistical data on sample size, mean, and standard deviation. Finally, the included study comprised a total of 526 participants. Mean difference (MD) and 95% confidence interval (CI) were used to synthesize the effect size in the data.Results11 studies were included. Due to the differences in the intervention methods, subgroup analysis was performed on the included research. Compared with the control group assessed by the Montreal Cognitive Assessment Scale, the single-task intervention improved the cognitive ability of the elderly with MCI (MD 3.40, 95% CI 2.43–4.37), the Mini-Mental State Examination Scale (MD 2.38, 95% CI −2.03 to 2.72), the Trail Making Test (MD −3.89, 95% CI −6.45 to −1.33), and the Digit Span Forward test (MD 1.16, 95% CI 0.73–1.60).ConclusionThis meta-analysis supports that exergames could be an effective cognitive rehabilitation method for MCI patients. Our study recommends that patients implement a customized exergames program and adhere to it for a long time. It is necessary to pay attention to the exercise guidelines and provide evidence from clinicians.Strengths and limitations of this study(1) This meta-analysis supports that exergames could be an effective cognitive rehabilitation method for MCI patients. Our study recommends that patients implement a customized exergames program and adhere to it for a long time. It is necessary to pay attention to the exercise guidelines and provide evidence from clinicians. (2) This research provides preliminary evidence for the clinical utility of VR tasks developed for mild cognitive impairment. (3) In this paper, only relevant studies in Chinese and English were searched, and no studies in other languages were searched.
Risk of drug-induced angioedema: a pharmacovigilance study of FDA adverse event reporting system database
Authors: Fan Maoxia , Niu Kaibin , Wu Xiaoqi , Shi Hongshuo 
Published: July 2024

ObjectiveThe purpose of this study is to explore and analyze the FDA Adverse Event Reporting System (FAERS) database to identify drug adverse reaction signals associated with angioedema. The findings aim to provide valuable insights for clinical drug safety considerations.MethodsThe Open Vigil 2.1 data platform was utilized to collect adverse event reports related to angioedema from the first quarter of 2004 to the fourth quarter of 2023. The reporting odds ratio (ROR) and proportional reporting ratio (PRR) were employed as disproportionality measures to detect adverse reaction signals Sof drugs associated with angioedema.ResultsA total of 38,921 reports were retrieved, with the majority being reported by healthcare professionals. The analysis included predominantly adult patients (≥18 years of age), with slightly higher representation of females compared to males. Among the top 30 drugs associated with the occurrence of angioedema, 24 drugs showed positive signals in the risk analysis. Based on the individual drug reporting odds ratio (95% confidence interval) as a measure of risk signal strength, the top five drugs are as follows: lisinopril [ROR (95% CI): 46.43 (42.59–50.62)], enalapril [ROR (95% CI): 43.51 (39.88–47.46)], perindopril [ROR (95% CI): 31.17 (27.5–35.32)], alteplase [ROR (95% CI): 29.3 (26.95–31.85)], ramipril [ROR (95% CI): 20.93 (19.66–22.28)]. After categorizing the drugs, the strongest positive signal was observed in the antithrombotic agents [ROR (95% CI): 22.53 (21.16–23.99)], following that, cardiovascular drugs [ROR (95% CI): 9.17 (8.87–9.48)], antibiotics [ROR (95% CI): 6.42 (5.91–6.96)], immunosuppressors [ROR (95% CI): 5.95 (5.55–6.39)], anti-inflammatory analgesics [ROR (95% CI): 4.65 (4.45–4.86)], antiallergic drugs [ROR (95% CI): 4.47 (3.99–5)], antiasthmatics [ROR (95% CI): 2.49 (2.14–2.89)], blood sugar control drugs [ROR (95% CI): 1.65 (1.38–1.97)], and digestive system drugs [ROR (95% CI): 1.59 (1.45–1.74)] exhibited progressively decreasing ROR values.ConclusionMany medications are associated with a high risk of angioedema. These medications play a crucial and potentially preventable role in controlling the occurrence of angioedema. It is essential to consider the risk level of drug-induced angioedema in clinical practice to optimize medication therapy.
Applying a clinical staging model in patients affected by schizophrenia spectrum disorder
Authors: de Filippis Renato , Carbone Elvira Anna , Rania Marianna , Aloi Matteo , Segura-Garcia Cristina , De Fazio Pasquale 
Published: July 2024

BackgroundClinical staging, already widespread in medicine, represents a new frontier in psychiatry. Our goal was to convert the existing theoretical staging model for schizophrenia into a feasible tool to have a timely assessment of patients’ health status applicable in any psychiatric facility.MethodsWe assessed the empirical soundness of a staging model for schizophrenia spectrum disorders (SSDs), primarily centered on their current status. This model delineated six sequential stages (1, 2A, 2B, 3A, 3B, and 4) based on factors like symptom recurrence, persistence, and progression, including functional decline. Our analysis involved data from 137 individuals affected by SSDs. We examined 22 baseline variables, 23 construct-related variables, and 31 potentially modifiable clinical variables.ResultsThe latter stages demonstrated significantly poorer outcomes compared to the early stages across various measures, indicating medium to large effect sizes and a dose–response pattern. This pattern confirmed the validity of the model. Notably, stages 2 and 3A exhibited pronounced differences in comparison to other stages, although variables from each validation category also distinguished between consecutive stages, particularly 3A and beyond.ConclusionBaseline predictors, such as familial predisposition to schizophrenia, neurodevelopmental impairment, childhood adversities, treatment delay, negative symptoms, neurological impairment, and inadequate early response to treatment, independently largely explained the staging variance. The clinical staging model, grounded in the extended course of psychosis, exhibited sound validity and feasibility, even without the use of biological or neuroimaging markers, which could greatly improve the sensitivity of the model. These findings provide insights into stage indicators and predictors of clinical stages from the onset of psychosis.
Preparation and validation of the instrument “QualiAPS digital—Brazil” for assessing digital health care in primary health care: a required tool
Authors: de Figueirêdo Renan Cabral , de Siqueira Silva Ísis , de Araújo Aguinaldo José , Silva Cícera Renata Diniz Vieira , Martiniano Cláudia Santos , Brito Ewerton William Gomes , Xavier Pedro Bezerra , da Costa Uchôa Severina Alice 
Published: July 2024

IntroductionThe use of Information and Communication Technologies in the field of health is increasing across the world, demarcating the field of digital health. The goal of this study is to formulate and validate a matrix of indicators, design assessment scripts and indicate data collection techniques for assessing the quality of digital health care in Brazilian Primary Health Care (PHC).MethodologyThis is a validation study divided into three phases: preparation of the instrument, analysis of validity and pilot study. The instrument was prepared based on the PHC assessment model from a literature review; the analysis of validity used the Delphi technique associated with the nominal group and the evidence from the literature reference. In the pilot study, audio-recorded interviews were conducted with strategic primary care actors.ResultsThe matrix of indicators “QualiAPS Digital—Brazil” introduces a set of 37 indicators, distributed into three distinct components and their respective dimensions. The component “Structure” includes the dimension “Resources”; the component “Processes” includes the dimensions “Technical,” “Organizational” and “Relational”; and the component “Results” includes the dimensions “Short-Term Results” and “Medium-Term Results.” The general values obtained for CVI and IRR were 0.89 and 1.00; respectively. Therefore, it was possible to design assessment scripts and indicate qualitative data collection techniques for assessing digital health in Brazilian PHC.ConclusionThe instrument presented was validated regarding its relevance, content and theoretical support to evaluate the quality of digital health care, supporting decision-making by managers and health professionals in the search for improving remote primary care provided to the population.
Evaluation of a football fitness implementation initiative for an older adult population in a small-scale island society
Authors: Skoradal May-Britt , Sjúrðarson Tórur , Olsen Helgi Winther , Leifsson Eli Nolsøe , Pelikan Vincent , Mohr Magni , Davidsen Annika Helgadóttir 
Published: July 2024

BackgroundThe proportion of older people increases globally, which calls for sustainable interventions promoting healthy aging. Therefore, we aimed to evaluate the potential of Football Fitness as a sustainable model to promote quality of life, mental health, and physical function for older adult.MethodsThe study was conducted in collaboration with a municipality, a football club, and a university, and was designed as a randomized controlled trial. A total of 66 people (34 women, 32 men) older than 60 years were randomly assigned (60/40) to a Football Fitness (FOT) (n = 38, 20 women, 18 men) and a control group (CON) (n = 28, 14 women, 14 men). FOT participated in Football Fitness for 12 weeks. Quality of life (QoL) and mental wellbeing were determined pre-and post-intervention. Physical loading and Flow experience were measured in one representative training session. Blood pressure (BP), Yo–Yo Intermittent endurance test level 1 (Yo–Yo IE1), sprint performance, postural balance, and body composition were also performed pre-and post-intervention.ResultsAn improvement in mental wellbeing was observed for both groups from pre- to post-intervention (p values &lt;0.001) with no between-group differences. Regarding QoL, the environment domain improved in FOT compared to CON (p = 0.02). Mean Flow (M = 5.69; SD = 1.07) and perceived importance (M = 4.20; SD = 1.42) and average experienced difficulty was M = 5.23 (SD = 2.67), perceived skill (M = 5.23; SD = 2.56), and perceived balance (M = 5.64; SD = 1.56). These levels of flow can be characterized as being high. A between-group effect (p = 0.02) existed for systolic BP, which decreased (p &lt; 0.01) by −5% [−8; −1%] in CON and remained unchanged in FOT. Both groups improved the Yo–Yo IE1 to a similar extent, with 28% [11; 44%] (p = 0.001) in FOT and 27% [9; 46%] in CON (p = 0.005). Postural balance improved (p = 0.004) by 38% [13; 63%] in FOT only, resulting in a superior (p = 0.01) balance score in FOT compared to CON post-intervention (p = 0.004).ConclusionFootball Fitness improved the environmental quality of life domain and postural balance in older adults. Additionally, it appears to be a feasible group activity for older adults that promotes high flow and physical loading during training.
The efficacy and safety of second salvage autologous transplantation in myeloma patients
Authors: Bicsko Reka Rahel , Nyilas Renata , Szasz Robert , Varoczy Laszlo , Kiss Attila , Udvardy Miklos , Illes Arpad , Gergely Lajos 
Published: July 2024

Despite the availability of many novel therapies for multiple myeloma, it remains an incurable disease with relapse fated in almost all patients. In the era of modern agents, second autologous stem cell transplantation still holds its role in patients relapsing after first-line autologous transplant. The authors reviewed a single-center experience with a second auto-SCT for relapsed multiple myeloma. Thirty patients had received a salvage auto-SCT at the institution. The median follow-up after diagnosis was 86 months, and the median time between transplants was 59.1 months. Response before second ASCT was the following: CR – 11 cases, VGPR – 9 cases, PR – 10 cases. Most patients received reduced dose (140 mg/m2) of melphalan as a conditioning regimen for the second auto-SCT. Treatment-related mortality was 3%. With a median follow-up time of 34 months after the second transplant, median progression-free survival was 24 months. The median PFS in the patients achieving CR or VGPR at day 100 after the second transplantation was 32 months. By 15 months, all patients achieved only partial remission progressed, with a median PFS of 8.5 months. During the follow-up period, no MDS or AML developed, and the frequency of second malignancy was also low, 3%. In conclusion, second autologous stem cell transplantation is a well-tolerated and effective treatment option for relapsed multiple myeloma in selected patients, though with a shorter PFS than in first remission.
Design of X-Band Circulator and Isolator for High-Peak-Power Applications
Authors: Tang Tao , Zhang Xiexun , Aldhaeebi Maged A. , Almoneef Thamer S. 
Published: July 2024

This paper presents a design of a X-band circulator–isolator for handling high-peak-power applications. The device consists of two cascade-connected ferrite circulators, with one dedicated to transmission and the other to small-signal reception coupled with high-power signal isolation. To improve the power capacity, a layer of poly-tetra fluoroethylene (PTFE) film is placed above and below the circulator’s and the isolator’s center conductors. Measurement results show that the device is capable of withstanding a peak power of 7000 W, with an insertion loss of <0.3 dB at the transmitting port. Similarly, it sustains a peak power of 6000 W with an insertion loss of <0.5 dB at the reception port. Moreover, the proposed design achieved isolation between the transmitting and receiving ends of >20 dB with a VSWR < 1.2 at each port. Thermal analysis shows that the maximum relative ambient temperature rise is 15.11 ∘C. These findings show that the proposed device achieves low-loss transmission of high-peak-power signals in the transmit channel and reverse isolation of high-peak-power signals in the receive channel.
Association of Symptoms and Collaborative Care Intervention with Systemic Inflammation Biomarkers in ESKD
Authors: Kallem Cramer J. , Alghwiri Alaa A. , Yabes Jonathan G. , Roumelioti Maria-Eleni , Erickson Sarah , Rollman Bruce L. , Weisbord Steven , Unruh Mark , Vodovotz Yoram , Jhamb Manisha , Steel Jennifer L. 
Published: July 2024

Key Points

There were no associations between biomarkers and patient-reported pain, fatigue, and depression in a large ESKD cohort at baseline.Compared with control, the Technology-Assisted stepped Collaborative Care intervention had a short-term impact on reducing inflammatory burden.Treatment modified the association between changes in symptoms and in certain proinflammatory biomarkers (TNF-α and high sensitivity C-reactive protein) over time.

Background
Patient-reported symptoms are associated with inflammation biomarkers in many chronic diseases. We examined associations of inflammation biomarkers with pain, fatigue, and depression in patients with ESKD and the effects of a Technology-Assisted stepped Collaborative Care (TĀCcare) intervention on these biomarkers.

Methods
In the TĀCcare multisite randomized control trial, data on patient-reported symptoms were collected at baseline and 3 and 6 months. Anti-inflammatory (IL-1 receptor agonist, IL-10), proinflammatory (TNF-α, high sensitivity C-reactive protein, IL-6), and regulatory (IL-2) biomarkers were assayed. Linear mixed-effects modeling was used to examine within-group and between-group differences after adjusting for age, sex, race, and comorbidities.

Results
Among the 160 patients (mean age 58±14 years, 55% men, 52% white), there were no significant associations between inflammation biomarkers and pain, fatigue, or depression at baseline. Both intervention and control groups demonstrated reductions in IL-10 and IL-1 receptor agonist over 6 months (β range=−1.22 to −0.40, P range=<0.001–0.02) At 3 months, the treatment group exhibited decreases in TNF-α (β=−0.22, P < 0.001) and IL-2 (β=−0.71, P < 0.001), whereas the control group showed increases in IL-6/IL-10 ratio (β=0.33, P = 0.03). At 6 months, both groups exhibited decreases in IL-2 (β range=−0.66 to −0.57, P < 0.001); the control group showed significant increases in the ratio of IL-6/IL-10 (β=0.75, P < 0.001) and decrease in TNF-α (β=−0.16, P = 0.02). Compared with controls, the treatment group demonstrated significantly decreased IL-2 at 3 months (β=−0.53, P < 0.001). Significant interaction effects of treatment were observed on the association between changes in proinflammatory biomarkers (TNF-α and high sensitivity C-reactive protein) levels and changes in symptom scores from baseline to 6 months.

Conclusions
The TĀCcare intervention had a short-term impact on reducing inflammatory burden in patients with ESKD. More studies are needed to confirm our findings and to determine whether these biomarkers mediate the link between symptoms and disease progression.

Clinical Trial registration number:
ClinicalTrials.gov NCT03440853.
Desenvolvimento de aplicativo para cirurgias endoscópicas com visualização direta em tempo real por meio de óculos 3D
Authors: Vargas Rogério Santos , Bringmann Deise Renata , Corso Leandro Luís 
Published: July 2024

A cirurgia geral tem passado por uma transformação significativa ao longo do tempo, graças à introdução e aprimoramento das técnicas minimamente invasivas. Essas técnicas são notáveis por reduzirem a morbidade pós-operatória e acelerarem o processo de recuperação em comparação com as abordagens convencionais de cirurgia aberta. A endoscopia tem se destacado como uma das modalidades cirúrgicas mais proeminentes, representando uma técnica fundamental na medicina contemporânea. Ao fornecer uma visão interna do corpo, a endoscopia tem revolucionado a abordagem cirúrgica, contribuindo significativamente para os avanços na área médica. Assim, este estudo tem como objetivo geral apresentar o desenvolvimento de um software para gerenciamento de cirurgias endoscópicas, que utiliza óculos 3D para visualização em tempo real. A proposta do software de gerenciamento é simplificar o processo cirúrgico, permitindo que os cirurgiões foquem diretamente na área cirúrgica enquanto visualizam a transmissão através dos óculos, evitando a necessidade de desviar a cabeça para um monitor. O processo de desenvolvimento do software passou por várias etapas, incluindo customização e testes piloto com médicos em diferentes locais. O sistema funciona com um capacete de realidade mista conectado a uma câmera óptica, permitindo que o cirurgião visualize o campo cirúrgico e o paciente através dos óculos. Além disso, o médico pode transmitir o procedimento para outros médicos através da internet. A adoção dessa tecnologia pode reduzir o tempo de internação e os custos, além de facilitar a cirurgia com maior precisão e favorecer uma melhor postura ergonômica. Essa tecnologia também tem potencial para ser utilizada em aulas e cirurgias com acompanhamento remoto em tempo real.
Avaliação da relação entre obesidade e a depressão na infância e juventude
Authors: Souza Fernanda Goulart Nunes de , Oliveira Marília Souza Bueno de , Marcon Maria Júlia Barco , Lima Ana Paula , Guilhen Gilmar Ledo , Morais Gabriela Rodrigues Silva de , Pascale Karina , Barboni Letícia de Jesus Dias , Bignardi Beatriz , Nenartavis Ana Claudia Martins , Jesus Tainah Marques de , Bonamin Natielly Luiza , Vasconcellos Cesar Augusto Galvao Banhatto 
Published: July 2024

INTRODUÇÃO: A obesidade é uma doença crônica causada pelo aumento do aporte calórico com aumento do tecido adiposo. A etiologia da doença é multifatorial e aflige a população de maneira global, inclusive a faixa etária infantil. Nessa idade, o aumento de peso interfere na interpretação corporal, o que influencia no desenvolvimento de doenças como a depressão. OBJETIVOS: Avaliar a relação entre a obesidade e a depressão infantil, avaliando a existência de fatores de risco associados. METODOLOGIA: Trata-se de uma revisão integrativa na base de dados PUBMED utilizando os descritores “OBESITY AND DEPRESSION AND CHILD’’ para artigos publicados entre 2019 e 2024. RESULTADOS: Um estudo de meta-análise demonstrou que a prevalência da obesidade entre crianças de até 14 anos é de 15,5%, dentre elas 10,4% apresentam depressão, um número alto quando comparado ao de crianças não obesas que é de 5%. A obesidade grave é comum em crianças que possuem depressão (26,8%), transtornos de ansiedade (18,4%) e transtornos alimentares (37,4%). O sexo feminino apresenta significativamente mais chances de desenvolver depressão quando comparado ao sexo masculino. Além disso, é importante analisar a autoimagem e a autoestima dessas crianças, uma vez que estudos demonstram que a insatisfação corporal é um importante fator de risco para a depressão. Os exercícios físicos são uma boa alternativa de tratamento para crianças afetadas com obesidade e depressão. CONCLUSÃO: A obesidade e a depressão estão associadas de maneira significativa, dando destaque às crianças do sexo feminino que apresentaram maiores chances de desenvolver depressão. Quanto ao tratamento, a atividade física, seguida pelas atividades em grupo, demonstraram resultados significativos no tratamento tanto da depressão, quanto da obesidade.