bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hadron production and propagation in pion-induced reactions on nuclei
Authors:   HADES collaboration, Yassine R. Abou , Adamczewski-Musch J. , Arnold O. , Atomssa E. T. , Becker M. , Behnke C. , Berger-chen J. C. , Blanco A. , Blume C. , Böhmer M. , Chlad L. , Chudoba P. , Ciepał I. , Deb S. , Deveaux C. , Dittert D. , Dreyer J. , Epple E. , Fabbietti L. , Fonte P. , Franco C. , Friese J. , Fröhlich I. , Förtsch J. , Galatyuk T. , Garzón J. A. , Gernhäuser R. , Greifenhagen R. , Grunwald M. , Gumberidze M. , Harabasz S. , Heinz T. , Hennino T. , Höhne C. , Hojeij F. , Holzmann R. , Idzik M. , Kämpfer B. , Kampert K.-H. , Kardan B. , Kedych V. , Koenig I. , Koenig W. , Kohls M. , Kolas J. , Kolb B. W. , Korcyl G. , Kornakov G. , Kotte R. , Krueger W. , Kugler A. , Kunz T. , Lalik R. , Lapidus K. , Linev S. , Linz F. , Lopes L. , Lorenz M. , Mahmoud T. , Maier L. , Malige A. , Markert J. , Maurus S. , Metag V. , Michel J. , Mihaylov D. M. , Mikhaylov V. , Molenda A. , Müntz C. , Münzer R. , Nabroth M. , Naumann L. , Nowakowski K. , Orliński J. , Otto J. -H. , Parpottas Y. , Parschau M. , Pauly C. , Pechenov V. , Pechenova O. , Piasecki K. , Pietraszko J. , Povar T. , Prościński K. , Prozorov A. , Przygoda W. , Pysz K. , Ramstein B. , Rathod N. , Rodriguez-Ramos P. , Rost A. , Rustamov A. , Salabura P. , Scheib T. , Schild N. , Schmidt-Sommerfeld K. , Schuldes H. , Schwab E. , Scozzi F. , Seck F. , Sellheim P. , Siebenson J. , Silva L. , Singh U. , Smyrski J. , Spataro S. , Spies S. , Stefaniak M. , Ströbele H. , Stroth J. , Sturm C. , Sumara K. , Svoboda O. , Szala M. , Tlusty P. , Traxler M. , Tsertos H. , Udrea I. C. , Vazquez-Doce O. , Wagner V. , Weber A. A. , Wendisch C. , Wiebusch M. G. , Wirth J. , Władyszewska A. , Zbroszczyk H. P. , Zherebtsova E. , Zielinski M. , Zumbruch P. , Curceanu C. , Piscicchia K. , Scordo A. 
Published: July 2024

AbstractHadron production ($$\pi ^\pm $$

π
±

, proton, $$\Lambda $$
Λ
, $$K_S^0$$

K
S
0

, $$K^\pm $$

K
±

) in $$\pi ^- + \textrm{C}$$

π
-

+
C

and $$\pi ^- + \textrm{W}$$

π
-

+
W

collisions is investigated at an incident pion beam momentum of $$1.7~\textrm{GeV}/c$$

1.7

GeV
/
c

. This comprehensive set of data measured with HADES at SIS18/GSI significantly extends the existing world data on hadron production in pion induced reactions and provides a new reference for models that are commonly used for the interpretation of heavy-ion collisions. The measured inclusive differential production cross-sections are compared with state-of-the-art transport model (GiBUU, SMASH) calculations. The (semi-) exclusive channel $$\pi ^- + A \rightarrow \Lambda + K_S^0 +X$$

π
-

+
A
→
Λ
+

K
S
0

+
X

, in which the kinematics of the strange hadrons are correlated, is also investigated and compared to a model calculation. Agreement and remaining tensions between data and the current version of the considered transport models are discussed.
Scalar induced gravitational waves in chiral scalar–tensor theory of gravity
Authors: Feng Jia-Xi , Zhang Fengge , Gao Xian 
Published: July 2024

AbstractWe study the scalar induced gravitational waves (SIGWs) from a chiral scalar–tensor theory of gravity. The parity-violating (PV) Lagrangian contains the Chern–Simons (CS) term and PV scalar–tensor terms, which are built of the quadratic Riemann tensor term and first-order derivatives of a scalar field. We consider SIGWs in two cases, in which the semi-analytic expression to calculate SIGWs can be obtained. Then, we calculate the fractional energy density of SIGWs with a monochromatic power spectrum for the curvature perturbation. We find that the SIGWs in chiral scalar–tensor gravity behave differently from those in GR before and after the peak frequency, which results in a large degree of circular polarization.
Enhanced four-body decays of charged Higgs bosons into off-shell pseudoscalar Higgs and $$W^\pm $$ boson pairs in a lepton-specific 2-Higgs doublet model
Authors: Moretti Stefano , Song Muyuan 
Published: July 2024

AbstractWe study the time-honoured decay $$H^\pm \rightarrow A W^\pm $$

H
±

→
A

W
±

but for the first time, we do so for the case of both A and $$W^\pm $$

W
±

being off-shell, therefore computing a $$1\rightarrow 4$$

1
→
4

body decay. We show that the corresponding decay rate not only extends the reach of $$H^\pm $$

H
±

searches to small masses of the latter but also that the results of our implementation differ significantly from the yield of the $$1\rightarrow 3$$

1
→
3

body decay over the phase space region in which the latter is normally used. We show the phenomenological relevance of this implementation in the case of the so-called lepton-specific 2-Higgs Doublet Model (2HDM) over the mass region wherein the aforementioned $$1\rightarrow 4$$

1
→
4

body decay can dominate just beyond the top (anti)quark mass. This mass region is accessible in the lepton-specific 2HDM as the Yukawa couplings are such that limits from $$b \rightarrow s \gamma $$

b
→
s
γ

and $$\tau \rightarrow \mu \nu _{\tau } \bar{\nu _\mu }$$

τ
→
μ

ν
τ

ν
μ

¯

observables on $$M_{H^\pm }$$

M

H
±

are rather mild. However, we emphasize that similar effects may occur in other 2HDM types, as the $$W^\pm H^\mp A$$

W
±

H
∓

A

vertex is 2HDM type independent.
Arginine Methylation of DDX3 by PRMT1 Mediates Mitochondrial Homeostasis to Promote Breast Cancer Metastasis
Authors: Hsu Wen-Jing , Chiang Ming-Chen , Chao Yi-Chun , Chang Yu-Chu , Hsu Ming-Chien , Chung Chu-Hung , Tsai I-Lin , Chu Cheng-Ying , Wu Han-Chung , Yang Ching-Chieh , Lee Chi-Ching , Lin Cheng-Wei 
Published: July 2024

Abstract
Dysregulated mitochondrial dynamics and metabolism play important roles in tumorigenesis. Metastasizing tumor cells predominantly utilize mitochondrial metabolism, and regulators of metabolic reprogramming may provide reliable biomarkers for diagnosing cancer metastasis. Here, we identified a type I arginine methyltransferase–DEAD-box polypeptide 3, X-linked (PRMT1-DDX3) axis that promotes breast cancer metastasis by coordinating mitochondrial biogenesis and mitophagy to ensure mitochondrial quality control. Mechanistically, PRMT1 induces arginine methylation of DDX3, which enhances its protein stability and prevents proteasomal degradation. DDX3 mediates mitochondrial homeostasis by translocating to mitochondria where it facilitates phosphatase and tensin homology-induced kinase 1 translation in response to mitochondrial stress. Inhibition of DDX3 suppresses mitochondrial biogenesis and mitophagy, resulting in diminished cancer stemness and metastatic properties. Overall, this study uncovers a mechanism by which the PRMT1-DDX3 axis regulates mitochondrial homeostasis to support breast cancer metastasis, suggesting strategies for targeting metabolic vulnerabilities to treat metastatic breast cancer.
Significance: DDX3 is stabilized by PRMT1–mediated arginine methylation and coordinates mitophagy and mitochondrial biogenesis by upregulating PINK1 to facilitate breast cancer progression.
Translational History and Hope of Immunotherapy of Canine Tumors
Authors: Bryan Jeffrey N. , Maitz Charles A. 
Published: July 2024

Abstract
Companion dogs have served an important role in cancer immunotherapy research. Sharing similar environments and diets with humans, dogs naturally develop many of the same cancers. These shared exposures, coupled with dogs’ diverse genetic makeup, make them ideal subjects for studying cancer therapies. Tumors like osteosarcoma, hemangiosarcoma, soft-tissue sarcoma, and non-Hodgkin lymphoma occur with greater frequency than their counterpart disease in humans. Canine brain tumors allow the study of therapy strategies with imaging, surgery, and radiotherapy equipment in veterinary patients with near-human geometry. Nonspecific immunostimulants, autologous and allogeneic vaccines, immune checkpoint inhibitors, and cellular therapies used in treating canine cancers have been tested in veterinary clinical trials. These treatments have not only improved outcomes for dogs but have also provided valuable insights for human cancer treatment. Advancements in radiation technology and the development of tools to characterize canine immune responses have further facilitated the ability to translate veterinary clinical trial results to human applications. Advancements in immunotherapy of canine tumors have directly supported translation to human clinical trials leading to approved therapies for patients with cancer around the world. The study of immunotherapy in dogs has been and will continue to be a promising avenue for advancing human cancer treatment.
Abstract 2112: Silent Killer: The Rare And Potentially Lethal Right Coronary Artery Aneurysm
Authors: khodor maya , Alkowatli hamza , Tashwali Sami 
Published: July 2024

Giant coronary artery aneurysms, defined as diameters larger than 20 mm, are exceedingly rare and constitute a life-threatening occurrence. This case involves a patient with a giant right coronary artery (RCA) aneurysm and multivessel coronary artery disease, successfully managed by surgical intervention through quintuple coronary artery bypass grafting (CABG).
A 65-year-old male with a history of hypertension presented with acute-onset chest pain. The initial workup revealed an inferolateral ST-segment elevation myocardial infarction (STEMI). The patient underwent emergency coronary angiography revealing a high-grade stenosis in the proximal and mid left anterior descending coronary artery, along with a remarkably tortuous and enlarged mid to distal RCA aneurysm measuring (21mm wide x 20mm long) and featuring significant post aneurysmal stenosis.
Attempts at percutaneous angioplasty were unsuccessful due to extensive thrombosis in the RCA. The patient continued to experience active chest pain, necessitating the placement of an intra-aortic balloon pump in the right common femoral artery, the insertion of a temporary pacemaker wire to address bradycardia, and the initiation of pressor support for hypotension. Additionally, intravenous heparin and antiplatelet therapy were administered. Finally, the patient underwent a quintuple CABG to address the multivessel disease.
Coronary artery aneurysm is an uncommon yet potentially perilous condition. The selection of appropriate management and intervention is crucial for averting fatal consequences associated with coronary artery aneurysms.
Tractography from T1-weighted MRI: Empirically exploring the clinical viability of streamline propagation without diffusion MRI
Authors: Cai Leon Y. , Lee Ho Hin , Johnson Graham W. , Newlin Nancy R. , Ramadass Karthik , Kim Michael E. , Archer Derek B. , Hohman Timothy J. , Jefferson Angela L. , Begnoche J. Patrick , Boyd Brian D. , Taylor Warren D. , Morgan Victoria L. , Englot Dario J. , Nath Vishwesh , Chotai Silky , Barquero Laura , D’Archangel Micah , Cutting Laurie E. , Dawant Benoit M. , Rheault François , Moyer Daniel C. , Schilling Kurt G. , Gore John C. , Landman Bennett A. 
Published: July 2024

Abstract
Over the last few decades, diffusion MRI (dMRI) streamline tractography has emerged as the dominant method for in vivo estimation of white matter (WM) pathways in the brain. One key limitation to this technique is that modern tractography implementations require high angular resolution diffusion imaging (HARDI). However, HARDI can be difficult to collect clinically, limiting the reach of tractography analyses to research cohorts and thus limiting many WM investigations to certain populations and pathologies. As such, a clinically viable tractography solution applicable to wider patient populations scanned as a part of routine care would be of key significance in broadening WM analyses to underfunded or rarer diseases and to the clinical setting. Such a solution would require the ability to perform arbitrary tractography analyses, use only clinical imaging for input, and be open source and widely accessible and implementable. Thus, here we evaluate our recently developed, containerized, and open-source, T1-weighted (T1w) MRI-based deep learning model for streamline propagation. We empirically assess its performance against traditional dMRI-based and established atlas-based approaches in a healthy young population, an aging one, and in those with epilepsy, depression, and brain cancer. In the healthy young population, we find slightly increased error compared to traditional tractography with the deep learning model that falls within the bounds attributable to dMRI variability and is considerably less than the atlas-based approach. Further, seeking to replicate previously published dMRI tractography effects in the remaining cohorts as an initial assessment of clinical viability, we find this model successfully does so in some key cases—particularly in applications that rely on long-range streamlines including those not captured by the atlas-based approach—but importantly not all. These results suggest a deep learning-based approach to tractography with T1w MRI demonstrates promise within the limitations of our definition of clinical viability and especially over atlas-based approaches but requires refinement and more robust consideration of out-of-distribution effects prior to widespread clinical use. We also find these results raise additional questions regarding the differences in image content between dMRI and T1w MRI and their relationship to tractography. Further investigation of these questions will improve the field’s understanding of which features of the brain influence measured tractography effects.
Association of Mechanical Axis With Osteochondritis Dissecans of the Femoral Condyle
Authors: Klueh Michael P. , Ren Bryan O. , Muscatelli Stefano R. , Grant John A. 
Published: July 2024

Background: Osteochondritis dissecans (OCD) is a condition characterized by abnormal subchondral bone with disturbance of overlying articular cartilage. The role of weightbearing alignment in the pathophysiology of OCD lesion development is not fully understood. Hypothesis: Lower extremity mechanical axis would be concordant with femoral condylar OCD lesion location. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Cases were identified from a single, large academic institutional database using International Classification of Diseases, Ninth Revision and Tenth Revision and Current Procedural Terminology codes associated with OCD. Patients were included if they had a magnetic resonance imaging scan demonstrating the OCD lesion and lower extremity alignment radiographs. OCD lesion location was identified using Cahill and Berg zones. The primary outcome was the association of OCD lesion location with weightbearing mechanical axis. Secondary outcomes included the association of mechanical axis with skeletal maturity, OCD lesion stability, and treatment. For unilateral OCD lesions, mechanical axis was compared between affected and unaffected lower extremities. Results: A total of 86 patients (95 knees) with an OCD lesion of the femoral condyle were identified. The population was 74% male, and the mean age was 21 years. In total, 65% of knees had closed physes, 82% of lesions were unstable, and 85% underwent a surgical procedure. Mechanical axis was located in the same zone as the OCD lesion in 48% of cases and within the same compartment in 56% of cases. Spearman correlation coefficient demonstrated a moderate positive correlation (rs = 0.59). No significant differences were found in the association of mechanical axis and OCD lesion location in subgroup analysis of medial versus lateral femoral condylar OCD lesions, skeletal maturity, stability of the lesion, or treatment group. For patients with varus alignment and medial femoral condylar OCD lesions, the mean lateral distal femoral angle was 89.9°, and medial proximal tibial angle was 85.4°; for valgus alignment and lateral femoral condylar lesions, the lateral distal femoral angle was 84.8°, and medial proximal tibial angle was 88.8°. Patients with unilateral medial femoral condylar OCD lesions were more likely to have varus alignment of the affected extremity compared with the contralateral extremity (59% vs 36%; P = .01). Conclusion: This study demonstrated a relationship between lower extremity mechanical weightbearing axis and femoral condylar OCD location. Patients with unilateral medial femoral condylar OCD lesions frequently had asymmetric varus alignment in the affected extremity.
Lived experience of ethical challenges among undergraduate nursing students during their clinical learning
Authors: Gonella Silvia , Viottini Elena , Gastmans Chris , Tambone Sara , Conti Alessio , Campagna Sara , Dimonte Valerio 
Published: July 2024

Background Undergraduate nursing students may experience several ethical challenges during their clinical learning placement that can lead to moral distress and intention to leave the profession. Ethical challenges are complex phenomena and ethical frameworks may help improve their understanding and provide actionable recommendations to enhance students’ readiness for practice. Aim To explore undergraduate nursing students’ ethical challenges experienced during their clinical learning and their suggestions for better ethics education; to illuminate students’ experience against a foundational ethical framework. Research design Qualitative study based on interpretative phenomenology. Semi-structured, in-person or at distance, one-to-one interviews were performed, audio-recorded, and transcribed verbatim. The ‘Dignity-enhancing care framework’ was employed to frame the study findings. Participants and research context Nineteen nursing graduands attending seven sites of one Northwestern Italian University were interviewed. Ethical consideration The study protocol was approved by the Ethics Committee of the University of Torino (number 0187646/2023). All participants provided written informed consent. Findings Students experienced several ethical challenges concerning daily practice such as pain control or the decision to restrain patients, and reported deficient professional ethics with healthcare professionals who demonstrated poor caring attitudes and teamwork. Moreover, they perceived professionals poorly committed to their role of educators and complained of poor support in the learning process. When a supportive, dialogical, and relational context lacked, students experienced negative feelings about the profession and the healthcare system and reported the intention to leave the profession. Dialogue with peers, family members or significant others, nursing educators, and clinical nurse supervisors, as well as self-learning activities and discussion-based teaching methods grounded on real scenarios helped to overcome challenging situations. Conclusion While complying with normative standards, nursing education policies should encourage the adoption of dynamic teaching methods and sustain a regular, dialogical approach within and between the clinical and academic contexts to improve readiness for practice.
Comparing Obtura Vascular Closure Device to Manual Compression for Achieving Hemostasis After Percutaneous Transfemoral Procedures: A Randomized Study
Authors: Devasia Tom , Premchand Rajendra Kumar , Sinha Santosh K. , Rewatkar Atul , Parikh Keyur , Arneja Jaspal 
Published: July 2024

Purpose: This trial was designed and aimed to compare safety and efficacy of Obtura™ vascular closure device (VCD) to manual compression (MC) among patients undergoing transfemoral catheterization. Material and Methods: This prospective, randomized, controlled, multicenter trial of Obtura VCD against MC randomized patients in 1:1 (n=268; 134:134) ratio. Safety and efficacy were measured by primary endpoints (time to hemostasis [TTH] and deployment success) and secondary endpoints which included technical success, device-related adverse events, and time to ambulation (TTA). Results: The procedural access using right femoral artery was performed in 95.52% of patients in Obtura VCD versus 96.27% in standard MC method, whereas 2.99% of patients in each group underwent left femoral access. Bilateral access was performed in 1.49% (n=2) versus 0.75% (n=1) in Obtura VCD versus MC, respectively. Both the technical success and deployment success were 100%. Patients in Obtura VCD group had shorter TTH (3.26±3.39 vs 23.95±8.24 minutes; p<0.0001) and TTA (155.44±125.32 vs 723.84±197.98 minutes; p<0.0001) than MC group. No access site complications (re-bleeding, infection, arteriovenous fistula, and transient access site nerve injury) were noted at 2-week, 1-month, and 3-month follow-ups. There were 4 (3%) and 6 (4.5%) cases of hematoma, respectively, in Obtura VCD versus MC and 1 case (0.7%) of post-procedural arterial pseudoaneurysm each in both the groups which were successfully resolved and patients were discharged with no further complications. Further follow-up was without any adverse events. Conclusions: The study demonstrated favorable safety and efficacy of Obtura™ VCD with a significantly short TTH and TTA compared to MC. Clinical Impact In patients undergoing cardiac catheterization, vascular closure devices (VCDs) can achieve hemostasis faster after successful implantation of the device with fewer complications such as bleeding and ambulation can be achieved faster. In terms of effectiveness, Obtura VCD was found to be better than manual compression in achieving early hemostasis and higher technical and deployment success was accomplished. Obtura VCD does not require enlargement of the route through the tissues, uses the same existing arterial sheath as its conduit, and does not cause patients’ access sites to feel uncomfortable while it is being deployed.
Retrieval of n-Butyl Cyanoacrylate Cast Migrated to the Dorsalis Pedis and Posterior Tibial Artery During Embolization of the Deep Circumflex Iliac Artery Using the Stent Retriever Device: A Case Report
Authors: Genez Samet , Yilmazsoy Yunus , Özer Hamza 
Published: July 2024

N-butyl cyanoacrylate (NBCA) is commonly used in interventional radiology procedures for its efficacy in vessel occlusion, yet it poses risks of embolic material migration. We present a unique case of NBCA cast migration during deep circumflex iliac artery (DCIA) embolization, leading to occlusion of the dorsalis pedis and posterior tibial arteries, subsequently retrieved using a stent retriever device. A 68-year-old woman with a history of heart valve replacement presented with a large intramuscular hematoma. N-butyl cyanoacrylate embolization of DCIA resulted in cast migration, occluding distal arteries. Retrieval was attempted using a stent retriever device, successfully restoring arterial flow. N-butyl cyanoacrylate use necessitates attention to vascular anatomy and test injections to mitigate complications. Stent retriever devices, originally designed for acute stroke thrombectomy, offer a viable solution for embolic material retrieval in vascular interventions. This case highlights successful NBCA cast retrieval in lower extremity arterial occlusion using a stent retriever device. Prompt recognition and intervention are crucial in mitigating complications associated with NBCA use. Stent retriever devices present a valuable tool for NBCA cast retrieval, preserving arterial perfusion in affected areas. Clinical Impact This case highlights the innovative application of stent retriever devices for retrieving migrated NBCA casts, traditionally used for stroke management in peripheral arterial occlusions. This adaptation offers clinicians a new, effective tool for managing embolization complications, such as unintended material migration that can cause severe ischemia. Implementing this technique could change clinical practice by providing a reliable method to swiftly address and resolve potentially limb-threatening situations, thereby improving patient outcomes and procedural safety. This advancement in interventional radiology enhances clinicians’ ability to handle complex embolic events with greater confidence and efficacy.