bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Proposed Model for Cryovolcanic Activity on Enceladus Driven by Volatile Exsolution
Authors: Mitchell Karl L. , Rabinovitch Jason , Scamardella Jonathan C. , Cable Morgan L. 
Published: July 2024

AbstractThere is considerable interest in sending a mission to Enceladus to sample its erupting materials, which are sourced from its ocean, a proposed habitable environment. However, we lack resolution between competing ascent and eruption models, which offer differing consequences and challenges for mission sampling and access strategies. We report a new Enceladus ascent and eruption model, “Cryo‐Erupt,” where ascent from ocean to jet is driven by the exsolution and expansion of dissolved gases from ascending water within conduits. This mechanism shares many similarities with some forms of terrestrial activity, including explosive silicate volcanism, cold‐water geysers and “limnic” eruptions. This preliminary study suggests that this mode of ascent and eruption is viable and broadly consistent with a range of observations including the apparent co‐existence of point‐ (jet) and fissure‐ (curtain) sourced activity as well as strong contrasts in velocity and ice‐to‐vapor ratio between the plume and the jets feeding it. However, it requires the co‐existence of a sublimation plume as an additive component to the broader plume. The outcomes of the Cryo‐Erupt model differ in terms of conduit physical and chemical processes from previously proposed boiling interface eruption models, for example, predicting larger dynamic pressures and narrower conduits, which could present challenges for direct robotic access. Due to the lack of a static boiling interface or wall condensation, bulk composition is unlikely to change appreciably during ascent from the ocean‐conduit interface to the jet, potentially simplifying the interpretation of samples collected in space or on Enceladus’ surface.
Predicting Mean Flow Through an Array of Cylinders
Authors: He F. , Draper S. , Ghisalberti M. , An H. , Branson P. 
Published: July 2024

AbstractThe present paper develops a new framework to predict the mean flow through an array of cylinders in which the flow around the array (array‐scale) and the flow around individual cylinders (element‐scale) are modeled separately using actuator disc theory and empirical drag models respectively, and then coupled through the net drag force. Applying this framework only requires knowledge of the array geometry and incident flow. The framework is validated using high‐fidelity direct numerical simulations for arrays of between 7 and 109 cylinders having different arrangements (staggered, concentric, random) and bounding shapes (circular, square) in both two‐ and three‐dimensional flows. In general, the framework outperforms existing models which require calibration and are only valid for part of the practical parameter space. The demonstrated scale separation suggests different combinations of element‐scale and array‐scale models/theories may be used for other arrangements of bluff bodies.
Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice
Authors: Weng Haobo , Zou Weijuan , Tian Fangyan , Xie Huilin , Liu Ao , Liu Wen , Liu Yu , Zhou Nianwei , Cai Xiaojun , Wu Jianrong , Zheng Yuanyi , Shu Xianhong 
Published: July 2024

AbstractHeart failure causes considerable morbidity and mortality worldwide. Clinically applied drugs for the treatment of heart failure are still severely limited by poor delivery efficiency to the heart and off-target consumption. Inspired by the high heart delivery efficiency of inhaled drugs, we present an inhalable cardiac-targeting peptide (CTP)-modified calcium phosphate (CaP) nanoparticle for the delivery of TP-10, a selective inhibitor of PDE10A. The CTP modification significantly promotes cardiomyocyte and fibroblast targeting during the pathological state of heart failure in male mice. TP-10 is subsequently released from TP-10@CaP-CTP and effectively attenuates cardiac remodelling and improved cardiac function. In view of these results, a low dosage (2.5 mg/kg/2 days) of inhaled medication exerted good therapeutic effects without causing severe lung injury after long-term treatment. In addition, the mechanism underlying the amelioration of heart failure is investigated, and the results reveal that the therapeutic effects of this system on cardiomyocytes and cardiac fibroblasts are mainly mediated through the cAMP/AMPK and cGMP/PKG signalling pathways. By demonstrating the targeting capacity of CTP and verifying the biosafety of inhalable CaP nanoparticles in the lung, this work provides a perspective for exploring myocardium-targeted therapy and presents a promising clinical strategy for the long-term management of heart failure.
Latitude-dependent oxygen fugacity in arc magmas
Authors: Hu Fangyang , Jiang Hehe , Wan Bo , Ducea Mihai N. , Gao Lei , Wu Fu-Yuan 
Published: July 2024

AbstractThe redox state of arc mantle has been considered to be more oxidized and diverse than that of the mid-ocean ridge, but the cause of the variation is debated. We examine the redox state of the Cenozoic global arc mantle by compiling measured/calculated fO2 of olivine-hosted melt inclusions from arc magma and modeled fO2 based on V/Sc and Cu/Zr ratios of arc basaltic rocks. The results indicate that the redox state of Cenozoic arc mantle is latitude dependent, with less oxidized arc mantle in the low latitudes, contrasting with a near constant across-latitude trend in the mid-ocean ridges. We propose that such a latitude-dependent pattern in the arc mantle may be controlled by the variation in the redox state of subducted sediment, possibly related to a latitudinal variation in the primary production of phytoplankton, which results in more organic carbon and sulfide deposited on the low-latitude ocean floor. Our findings provide evidence for the impact of the surface environment on Earth’s upper mantle.
Slab steepening and rapid mantle wedge replacement during back-arc rifting in the New Hebrides
Authors: Haase Karsten M. , Regelous Marcel , Beier Christoph , Koppers Anthony A. P. 
Published: July 2024

AbstractThe effects of the composition and angle of the subducting slab and mantle wedge flow on tectonic and magmatic processes in island arcs and associated back-arcs are poorly understood. Here we analyse the ages and compositions of submarine lavas from the flanks and the floor of the back-arc Futuna Trough some 50 km east of Tanna Island in the New Hebrides arc front. Whereas >2.5 Ma-old back-arc lavas formed from an enriched mantle source strongly metasomatized by a slab component, the younger lavas show less slab input into a depleted mantle wedge. The input of the slab component decreased over the past 2.5 million years while the enriched mantle was replaced by depleted peridotite. The change of Futuna Trough lava compositions indicates rapid (10 s of km/million years) replacement of the mantle wedge by corner flow and slab steepening due to rollback, causing extensional stress and back-arc rifting in the past 2.5 million years.
Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo
Authors: Vicidomini Rosario , Choudhury Saumitra Dey , Han Tae Hee , Nguyen Tho Huu , Nguyen Peter , Opazo Felipe , Serpe Mihaela 
Published: July 2024

AbstractNeurexins are key adhesion proteins that coordinate extracellular and intracellular synaptic components. Nonetheless, the low abundance of these multidomain proteins has complicated any localization and structure-function studies. Here we combine an ALFA tag (AT)/nanobody (NbALFA) tool with classic genetics, cell biology and electrophysiology to examine the distribution and function of the Drosophila Nrx-1 in vivo. We generate full-length and ΔPDZ ALFA-tagged Nrx-1 variants and find that the PDZ binding motif is key to Nrx-1 surface expression. A PDZ binding motif provided in trans, via genetically encoded cytosolic NbALFA-PDZ chimera, fully restores the synaptic localization and function of NrxΔPDZ-AT. Using cytosolic NbALFA-mScarlet intrabody, we achieve compartment-specific detection of endogenous Nrx-1, track live Nrx-1 transport along the motor neuron axons, and demonstrate that Nrx-1 co-migrates with Rab2-positive vesicles. Our findings illustrate the versatility of the ALFA system and pave the way towards dissecting functional domains of complex proteins in vivo.
Constrained patterning of orientated metal chalcogenide nanowires and their growth mechanism
Authors: Yang Qishuo , Wang Yun-Peng , Shi Xiao-Lei , Li XingXing , Zhao Erding , Chen Zhi-Gang , Zou Jin , Leng Kai , Cai Yongqing , Zhu Liang , Pantelides Sokrates T. , Lin Junhao 
Published: July 2024

AbstractOne-dimensional metallic transition-metal chalcogenide nanowires (TMC-NWs) hold promise for interconnecting devices built on two-dimensional (2D) transition-metal dichalcogenides, but only isotropic growth has so far been demonstrated. Here we show the direct patterning of highly oriented Mo6Te6 NWs in 2D molybdenum ditelluride (MoTe2) using graphite as confined encapsulation layers under external stimuli. The atomic structural transition is studied through in-situ electrical biasing the fabricated heterostructure in a scanning transmission electron microscope. Atomic resolution high-angle annular dark-field STEM images reveal that the conversion of Mo6Te6 NWs from MoTe2 occurs only along specific directions. Combined with first-principles calculations, we attribute the oriented growth to the local Joule-heating induced by electrical bias near the interface of the graphite-MoTe2 heterostructure and the confinement effect generated by graphite. Using the same strategy, we fabricate oriented NWs confined in graphite as lateral contact electrodes in the 2H-MoTe2 FET, achieving a low Schottky barrier of 11.5 meV, and low contact resistance of 43.7 Ω µm at the metal-NW interface. Our work introduces possible approaches to fabricate oriented NWs for interconnections in flexible 2D nanoelectronics through direct metal phase patterning.
Whole-genome sequencing of 13 Arctic plants and draft genomes of Oxyria digyna and Cochlearia groenlandica
Authors: Kim Jun , Lim Jiseon , Kim Moonkyo , Lee Yoo Kyung 
Published: July 2024

AbstractTo understand the genomic characteristics of Arctic plants, we generated 28–44 Gb of short-read sequencing data from 13 Arctic plants collected from the High Arctic Svalbard. We successfully estimated the genome sizes of eight species by using the k-mer-based method (180–894 Mb). Among these plants, the mountain sorrel (Oxyria digyna) and Greenland scurvy grass (Cochlearia groenlandica) had relatively small genome sizes and chromosome numbers. We obtained 45 × and 121 × high-fidelity long-read sequencing data. We assembled their reads into high-quality draft genomes (genome size: 561 and 250 Mb; contig N50 length: 36.9 and 14.8 Mb, respectively), and correspondingly annotated 43,105 and 29,675 genes using ~46 and ~85 million RNA sequencing reads. We identified 765,012 and 88,959 single-nucleotide variants, and 18,082 and 7,698 structural variants (variant size ≥ 50 bp). This study provided high-quality genome assemblies of O. digyna and C. groenlandica, which are valuable resources for the population and molecular genetic studies of these plants.
Chromosome-level genome assembly of the two-spotted spider mite Tetranychus urticae
Authors: Cao Li-Jun , Guan Tian-Bo , Chen Jin-Cui , Yang Fangyuan , Liu Jing-Xian , Jin Feng-Liang , Wei Shu-Jun 
Published: July 2024

AbstractThe two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), is a notorious pest in agriculture that has developed resistance to almost all chemical types used for its control. Here, we assembled a chromosome-level genome for the TSSM using Illumina, Nanopore, and Hi-C sequencing technologies. The assembled contigs had a total length of 103.94 Mb with an N50 of 3.46 Mb, with 87.7 Mb of 34 contigs anchored to three chromosomes. The chromosome-level genome assembly had a BUSCO completeness of 94.8%. We identified 15,604 protein-coding genes, with 11,435 genes that could be functionally annotated. The high-quality genome provides invaluable resources for the genetic and evolutionary study of TSSM.
Chromatin conformation and histone modification profiling across human kidney anatomic regions
Authors: Li Haikuo , Li Dian , Humphreys Benjamin D. 
Published: July 2024

AbstractThe three major anatomic regions of the human kidney include the cortex, medulla and papilla, with different functions and vulnerabilities to kidney diseases. Epigenetic mechanisms underlying these anatomic structures are incompletely understood. Here, we performed chromatin conformation capture with Hi-C and histone modification H3K4me3/H3K27me3 Cleavage Under Targets and Release Using Nuclease (CUT&RUN) sequencing on the kidney cortex, medulla and papilla dissected from one individual donor. Nuclear suspensions were generated from each region and split subjected to paired Hi-C and CUT&RUN sequencing. We evaluated the quality of next-generation sequencing data, Hi-C chromatin contact matrices and CUT&RUN peak calling. H3K4me3 and H3K27me3 histone modifications represent active and repressive gene transcription, respectively, and differences in chromatin conformation between kidney regions can be analyzed with this dataset. All raw and processed data files are publicly available, allowing researchers to survey the epigenetic landscape across regional human kidney anatomy.
Comprehensive insights on genetic alterations and immunotherapy prognosis in Chinese melanoma patients
Authors: Jia Dong-Dong , Li Tao 
Published: July 2024

AbstractImmune checkpoint inhibitors (ICI) have emerged as a promising therapeutic option for melanoma, which demonstrating improved clinical outcomes in melanoma patients regardless of specific genetic mutations. However, the identification of reliable biomarkers for predicting immunotherapy response and prognosis remains a challenge. In this study, we performed genetic profiling of the melanoma patients with different subtypes and evaluated the efficacy of ICI treatment. A total of 221 melanoma patients were included in our cohort, consisting primarily of acral lentiginous melanoma (ALM), cutaneous malignant melanoma (CMM), and mucosal malignant melanoma (MMM). Genetic analysis revealed BRAF mutations was predominant in CMM and NRAS mutations was prevalent in ALM. Copy number variants (CNVs) and structural variants (SV) were also detected, with CCND1 and CDK4 being the most affected genes in CNV and BRAF, ALK and RAF1 being the druggable targets in SV. Furthermore, NRAS mutations were associated with a poor prognosis in ALM, while TERT mutations were linked to unfavorable outcomes in CMM after receiving PD-1 therapy. Additionally, ALK expression exhibited improved outcomes in both ALM and CMM subtypes. Our study provides a comprehensive genomic and pathological profiling of Chinese melanoma patients, shedding light on the molecular landscape of the disease. Furthermore, numbers of gene mutations and ALK expression were identified as prognostic indicators. These findings contribute to the understanding of melanoma genetics in the Chinese population and have implications for personalized treatment approaches.
Enduring maternal brain changes and their role in mediating motherhood’s impact on well-being
Authors: Rotondi Valentina , Allegra Michele , Kashyap Ridhi , Barban Nicola , Sironi Maria , Reverberi Carlo 
Published: July 2024

AbstractParenthood, particularly motherhood, is known to impact the structure and function of the brain in the short term, but the long-term effects of parenthood and their impacts on well-being are still poorly understood. This study explores the potential longer-term associations between parenthood and the brain, parenthood and well-being, and the potential role of brain modifications in influencing mothers’ well-being. Using data from the UK Biobank, which includes brain imaging information from individuals aged 45–82 at the MRI scanning, we discovered differences in brain structure between mothers and non-mothers, with mothers exhibiting widely distributed higher gray matter density, particularly strong in frontal and occipital regions. No brain changes were observed in fathers. Parents reported a higher sense of life’s meaning compared to their childless counterparts. Gray matter changes did not mediate the relationship between motherhood and well-being. This suggests that the alterations in gray matter associated with motherhood do not play a deterministic role in shaping long-term changes in well-being.
Ultra-broadband and high extinction ratio polarization splitter based on triple-tapered directional couplers
Authors: Faramarzi Hamed , Soltani Afsoun , Firouzeh Zaker Hossein , Zeidaabadi Nezhad Abolghasem , Safian Reza 
Published: July 2024

AbstractThe design and numerically investigation of a silicon polarization splitter (PS) is proposed using triple-tapered directional couplers (DCs).The proposed device consists of a triple-tapered DC, a triple-bent DC at through port, and a tapered waveguide at cross port. The coupling length of the device is 20.5 µm. At the 1550 nm wavelength, the realized PS exhibits the extinction ratio (ER) values of 35.7 dB and 37.35 dB as well as the insertion loss values of < 0.58 dB and < 0.4 dB for the TE and TM polarization modes, respectively. Furthermore, the device’s bandwidth for ER > 20 dB and ER > 25 dB are 170 nm and 136 nm, respectively.
Baseline biomarkers of efficacy and on-treatment immune-profile changes associated with bempegaldesleukin plus nivolumab
Authors: Gogas Helen , Ravimohan Shruthi , Datta Antara , Chhibber Aparna , Couselo Eva Muñoz , Diab Adi , Pereira Caio , Quéreux Gaëlle , Sandhu Shahneen , Curti Brendan , Khushalani Nikhil I. , Taylor Matthew H. , Daniels Gregory A. , Spreafico Anna , Meniawy Tarek , Van Den Eertwegh Alfons J. M. , Sun Yongliang , Arriaga Yull , Zhou Ming , Long Georgina V. , Lebbé Céleste 
Published: July 2024

AbstractIn PIVOT IO 001 (NCT03635983), the combination of the investigational interleukin-2 agonist bempegaldesleukin (BEMPEG) with nivolumab (NIVO) had no added clinical benefit over NIVO monotherapy in unresectable/metastatic melanoma. Pre-defined baseline and on-treatment changes in selected biomarkers were analyzed to explore the potential mechanisms underlying the clinical observations. In each treatment arm, higher baseline tumor mutational burden or immune infiltration/inflammation was associated with improved efficacy compared with lower levels. On-treatment peripheral biomarker changes showed that BEMPEG + NIVO increased all immune cell subset counts interrogated, including regulatory T cells. This was followed by attenuation of the increase in CD8 + T cells, conventional CD4 + T cells, and systemic interferon gamma levels at later treatment cycles in the combination arm. Changes in tumor biomarkers were comparable between arms. These biomarker results help provide a better understanding of the mechanism of action of BEMPEG + NIVO and may help contextualize the clinical observations from PIVOT IO 001.
Simultaneous optical power insensitivity and non-volatile wavelength trimming using 2D In4/3P2Se6 integration in silicon photonics
Authors: Tamalampudi Srinivasa Reddy , Dushaq Ghada , Serunjogi Solomon M. , Rajput Nitul S. , Rasras Mahmoud S. 
Published: July 2024

AbstractIn integrated photonic circuits, microring resonators are essential building blocks but are susceptible to phase errors due to fabrication imperfections and optical power fluctuations. Conventional active phase tuning methods are power-intensive and challenging to integrate into densely packed photonic chips. This study proposes a solution by integrating a thin 2D layer of In4/3P2Se6(InPSe) onto silicon microring resonators (Si-MRR). This approach mitigates sensitivity to laser power and achieves non-volatile wavelength trimming. Under bias voltage, the device exhibits electro-optic behavior, offering a non-volatile phase trimming rate of −2.62 pm/V to −4.62 pm/V, corresponding to InPSe thicknesses of 45 nm to 120 nm. Low optical losses of 0.0091 to 0.0361 dB/μm were also measured, corresponding to thicknesses of 30 nm to 120 nm. The devices demonstrate stable in-situ resonance wavelength stabilization and bidirectional trimming, ensuring cyclic stability for non-volatile phase control. This advancement enhances the performance of silicon photonics across diverse applications, facilitating high-capacity, high-power operation in compact designs.
Efficient methane oxidation to formaldehyde via photon–phonon cascade catalysis
Authors: Xu Youxun , Wang Chao , Li Xiyi , Xiong Lunqiao , Zhang Tianyu , Zhang Liquan , Zhang Qinghua , Gu Lin , Lan Yang , Tang Junwang 
Published: July 2024

AbstractThe oxidation of methane to value-added chemicals provides an opportunity to use this abundant feedstock for sustainable petrochemistry. Unfortunately, such technologies remain insufficiently competitive due to a poor selectivity and a low yield rate for target products. Here we show a photon–phonon-driven cascade reaction that allows for methane conversion to formaldehyde with an unprecedented productivity of 401.5 μmol h−1 (or 40,150 μmol g−1 h−1) and a high selectivity of 90.4% at 150 °C. Specifically, with a ZnO catalyst decorated with single Ru atoms, methane first reacts with water to selectively produce methyl hydroperoxide via photocatalysis, followed by a thermodecomposition step yielding formaldehyde. Single Ru atoms, serving as electron acceptors, improve charge separation and promote oxygen reduction in photocatalysis. This reaction route with minimized energy consumption and high efficiency suggests a promising pathway for the sustainable transformation of light alkanes.
A size-dependent division strategy accounts for leukemia cell size heterogeneity
Authors: Miotto Mattia , Scalise Simone , Leonetti Marco , Ruocco Giancarlo , Peruzzi Giovanna , Gosti Giorgio 
Published: July 2024

AbstractHeterogeneity in the size distribution of cancer cell populations is linked to drug resistance and invasiveness. However, understanding how such heterogeneity arises is still damped by the difficulties of monitoring the proliferation at the typical timescales of mammalian cells. Here, we show how to infer the growth regime and division strategy of leukemia cell populations using live cell fluorescence labeling and flow cytometry in combination with an analytical model where cell growth and division rates depend on powers of the size. We found that the dynamics of the size distribution of Jurkat T-cells is reproduced by (i) a sizer-like division strategy, with (ii) division times following an Erlang distribution and (iii) fluctuations up to ten percent of the inherited fraction of size at division. Overall, our apparatus can be extended to other cell types and environmental conditions allowing for a comprehensive characterization of the growth and division model different cells adopt.