bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tropical Cyclone Wind Shear-Relative Asymmetry in Reanalyses
Authors: Carstens Jacob D. , Didlake Anthony C. , Zarzycki Colin M. 
Published: August 2024

Abstract
While tropical cyclones (TCs) are axisymmetric vortices to the first order, they often exhibit noteworthy structural asymmetries. These often result from environmental vertical wind shear, which tilts the vortex and induces a wavenumber 1 pattern in the circulation and precipitation fields. Reanalyses and climate models have improved in representing the TC structure and climatology, but their relatively coarse resolution and dependence on parameterized physics cast doubt on their ability to capture the asymmetric TC structure. We perform the most comprehensive process-oriented assessment of TC asymmetry to date in reanalyses. Specifically, we analyze the composite shear-relative TC structure in ERA5 and Climate Forecast System Reanalysis (CFSR), which vary in their resolutions, physical parameterization suites, and data assimilation techniques. These structures are compared with aircraft reconnaissance radar observations. In agreement with the observations, the strongest tangential winds are usually found left-of-shear, while inner core rainfall, ascent, vortex tilt, and low-level inflow are favored directly downshear or in the downshear-left quadrant. Outer rainband convection generally peaks in the downshear-right quadrant. Thermodynamic asymmetries are also apparent, with anomalous low-level moisture right-of-shear, midlevel warmth in the upshear-right quadrant (uptilt), and cloud properties suggestive of a realistic precipitation life cycle from growth to fallout. We also decompose rainfall contributions from the convective parameterization and large-scale cloud schemes and highlight the roles of vorticity advection, buoyancy advection, and diabatic processes in driving asymmetric vertical motions in the inner core and outer rainband regions. Our results suggest that process-level studies of TC asymmetry and TC–wind shear interaction under future warming are viable using climate models.

Significance Statement
Asymmetries are common in tropical cyclones (TCs), influencing their intensity, track, and hazards. Vertical wind shear often plays a leading-order role in causing these asymmetries. It is uncertain how well asymmetric structures and processes are captured in reanalyses and global climate models (GCMs) with grid spacings of 0.25° and coarser. In this study, we first evaluate TC asymmetry in reanalyses, which have the benefit of being forced by observations. This helps to assess whether the resolutions associated with GCMs sufficiently capture asymmetric structures and processes and motivates upcoming work with free-running GCMs to study how TC asymmetry may change in a warming climate.
Air–Sea Coupling Feedbacks over Tropical Instability Waves
Authors: Holmes Ryan M. , Renault Lionel , Maillard Lisa , Boucharel Julien 
Published: August 2024

Abstract
Tropical instability waves (TIWs) are oceanic features that form around the equatorial Pacific cold tongue and influence the large-scale circulation and coupled climate variability including El Niño–Southern Oscillation. Local air–sea coupling over TIWs is thought to play an important role in the atmosphere and ocean’s energy and tracer budgets but is not well captured in coarse-resolution models. In this study, we isolate the impacts of TIW thermal (sea surface temperature–driven) and current (surface current–driven) feedbacks by removing TIW signatures in air–sea coupling fields in a high-resolution regional coupled model. The thermal feedback is found to damp TIW temperature variance by a factor of 2, associated both with the direct dependence of surface heat fluxes on SST (∼74%) and indirect impacts on surface winds (∼35%) and air temperature and humidity (∼−9%). These changes lead to cooling of the cold tongue SST by up to 0.1°C through reduced TIW-driven meridional heat fluxes and associated small changes in atmospheric circulation. The current feedback is decomposed into TIW (i.e., mesoscale) and mean (i.e., large-scale) components using separate experiments, with both having distinct impacts on TIWs and the mean state. The mesoscale current feedback reduces TIW eddy kinetic energy (EKE) by 22% through the eddy wind work, while the mean current feedback induces a further reduction of 8% by extracting energy from the mean currents and thus reducing barotropic EKE shear production. An improved understanding of small-scale tropical Pacific processes is needed to address biases in coarse-resolution models that impact their predictions and projections of Pacific climate variability and change.

Significance Statement
Tropical instability waves (TIWs) are oceanic features with ∼1000-km wavelengths that propagate westward on either side of the eastern equatorial Pacific cold tongue. TIWs drive lateral and vertical heat fluxes that impact several aspects of El Niño–Southern Oscillation. While climate models with a moderate, 1/4° ocean resolution can capture some TIW variability, they fail to properly represent many associated processes such as the impact of TIWs on the overlying atmosphere. Using sensitivity studies performed using a high-resolution regional coupled model, we study the impact of TIW air–sea coupling on the eastern Pacific climate system. Increased understanding of small-scale processes from studies such as this is essential to understand and address biases in models used for seasonal climate predictions and projections in the Pacific region.
Sample comparison of BÜHLMANN fCAL Turbo and OC-FCa faecal calprotectin methods
Authors: O’Driscoll Shane , Piggott Carolyn , Benton Sally C 
Published: August 2024

Background Faecal calprotectin is an inflammatory marker used to triage patients for further investigation with suspected inflammatory bowel disease (IBD). Our current method requires faecal samples be sent to the laboratory, where calprotectin is extracted before analysis. This is a time-consuming, potential bottleneck in the pathway. We have recently evaluated the OC-SENSOR PLEDIA fCAL method that uses the same sampling device as used in some bowel cancer screening and symptomatic colorectal cancer programmes that detect faecal haemoglobin. The below study is a comparison of the OC-FCa method with the BÜHLMANN fCAL Turbo which is used routinely within BSPS. Method 150 homogenised and 110 non-homogenised faecal samples were loaded into OC-Sampling Bottle 3 and BÜHLMANN CALEX cap sampling devices. The samples were then analysed on their respective systems according to manufacturer’s instructions. Results The OC-FCa assay had a mean positive bias of 67.3% (homogenised) and 88.4% (non-homogenised). Homogenised samples showed substantial agreement between the methods for normal (<50 µg/g) and elevated (150+µg/g) risk categories (k = 0.794, k = 0.788, respectively) and moderate agreement for borderline (51–150 µg/g) (k = 0.25) according to the current Berkshire and Surrey Pathology Service (BSPS) guidelines. Non-homogenised samples had none to slight agreement for normal and borderline values (k = 0.02 for both) and moderate agreement for elevated (k = 0.596). Conclusion The OC-FCa method is a viable alternative for faecal calprotectin testing, but requires an adjustment to clinical cut-off values due to the lack of standardisation and strong positive bias. A clinical comparative study is required to assess the impact of patients collecting their own samples into the devices, as this may negate any potential degradation samples may exhibit during transit to the laboratory.
A three-model approach to understand social media-mediated transparency in public administrations
Authors: Villodre Julián 
Published: August 2024

The use of social media has promised to enhance administrative transparency. Whether having positive or negative impacts, some scholars agree that such impacts could come from the mediating effects of the perceived characteristics of social media. This is a similar idea to that proposed by the concept of computer-mediated transparency. However, social media has certain properties that might influence transparency in different ways. This article tries to understand social media-mediated transparency. The study uses the affordances theory to approach the perception of social media properties, conducting interviews with community managers from three Spanish city councils. The results show several ways of understanding social media-mediated transparency: the guarantor model (focuses on availability and accessibility of information, while ensuring neutrality), the conversational model (reinforces effective transparency through continuous conversations), and the proactive model (anticipates citizen informational needs). The article signals the differential nature of social media-mediated transparency and its limits, with implications for digital government–citizen interactions. Points for practitioners The article proposes three different ways of looking at social media-mediated transparency. Social media-mediated transparency will vary depending on how public managers navigate through social media affordances. Different models of social media-mediated transparency might link with different ways of institutionalizing these digital platforms, as well as with different considerations on citizens’ roles. Transparency through social media is more than just pushing information, but also an opportunity to improve effective monitoring through continuous conversations.
Narrative Review of Paraphilias: An Indian Perspective
Authors: Thakur Manish Roshan , Yadav Ravi , Bhanwar Rajvardhan Singh 
Published: August 2024

Introduction: Paraphilias, encompassing a diverse range of atypical sexual interests and behaviors, have been a subject of profound interest and scrutiny throughout history. These sexual interests are a matter of debate with the changing society and also with the changing world view. The rise in awareness about abnormal sexual interests also poses difficulty in adding to the existing list. Objectives: This article aims to provide a comprehensive exploration of the historical underpinnings, current diagnostic criteria, legal considerations in India, and treatment approaches available for paraphilias. Methodology: Electronic searches were done on PubMed, Science Direct, Web of Science, and Google Scholar. Search term included were “paraphilias,” “history,” “nosology,” “legislation,” “law,” “treatment guidelines,” and “treatment recommendations” in various combinations. An independent online search was also conducted for historical and legal aspects of India. Results: The classification and understanding of paraphilias have evolved over time, with some being removed from criminalized groups and laws and legislation changing based on societal norms. ICD and DSM have become more structured, but need constant updating. India's laws need to be more specific and streamlined, and guidelines have not been assessed for effectiveness. Paraphilias has been treated as a foster child in psychiatry, raising concerns about treatment options.
Childhood Trauma, Emotional Regulation, Alexithymia, and Psychological Symptoms Among Adolescents: A Mediational Analysis
Authors: Sharma Prerna , Sen Mahadev Singh , Sinha Uday Kumar , Kumar Deepak 
Published: August 2024

Background: Adolescents’ mental health is influenced by childhood trauma, emotional regulation, and psychological symptoms. This study aimed to explore these interconnections among adolescents attending a child and adolescent clinic. Method: Adolescents aged 13-19 from a city were recruited through purposive sampling. Data were collected using the Child Behavior Checklist (CBCL), Childhood Trauma Questionnaire-Short Form (CTQ), Difficulties in Emotion Regulation Scale (DERS), and Toronto Alexithymia Scale-20. Adolescents with severe mental or physical illnesses were excluded. Results: A total of 100 participants were recruited aged 13-19. The CTQ scores positively correlated with DERS Scores ( r = 0.246, P < .05) and Internalizing scores ( r = 0.325, P < .01). DERS Scores strongly correlated with alexithymia ( r = 0.624, P < .001) and Internalizing scores( r = 0.556, P < .001). Regression analyses revealed CTQ, Alexithymia, and DERS scores significantly predicted Internalizing scores ( R2 = 0.37). Mediation analysis showed that emotional regulation partially mediated the relationship between child trauma and Internalizing scores ( B = 0.059, 95% confidence interval [CI] = 0.011 to 0.133, t = 1.92, P = .01), as well as the relationship between Alexithymia and Internalizing scores( B = 0.255, 95% CI = 0.129 to 0.465, t = 3.31, P < .001). Conclusion: Findings highlight the importance of emotional regulation as a mediator in the connections between childhood trauma, alexithymia, and psychological symptoms among adolescents. This complementary mediation underscores the dual impact of direct and indirect effects on psychological well-being. The findings reveal intricate links between childhood trauma, emotional regulation, and alexithymia in adolescents with psychological symptoms. Emotional regulation proved to have a pivotal role in influencing psychological well-being. These results emphasize the importance of considering emotional regulation when assessing and maintaining mental health in adolescents, further contributing to understanding treatment needs.
Prevalence and Classification of Pediatric Neuromuscular Disorders in the Central Region of Portugal
Authors: Machado Rita , Costa Carmen , Fineza Isabel , Ribeiro Joana Afonso 
Published: August 2024

Neuromuscular disorders are a group of rare heterogenous diseases with profound impact on quality of life, for which overall pediatric prevalence has rarely been reported. The purpose of this study was to determine the point prevalence of pediatric neuromuscular disorders and its subcategories in the central region of Portugal. Retrospective case identification was carried out in children with neuromuscular disorders seen between 1998 and 2020 from multiple data sources. Demographics, clinical and molecular diagnoses were registered. On January 1, 2020, the point overall prevalence in the population <18 years of age was 41.20/100 000 (95% confidence interval 34.51-49.19) for all neuromuscular disorders. The main case proportion were genetic disorders (95.7%). We found a relatively higher occurrence of limb-girdle muscular dystrophies, congenital myopathies, and spinal muscular atrophy and a slightly lower occurrence of Duchenne muscular dystrophy, hereditary spastic paraparesis, and acquired neuropathies compared to previous studies in other countries. Molecular confirmation was available in 69.5% of pediatric neuromuscular patients in our cohort. Total prevalence is high in comparison with the data reported in the only previous study on the prevalence of pediatric neuromuscular disorders in our country. Our high definitive diagnostic rate underscores the importance of advances in investigative genetic techniques, particularly new sequencing technologies, in the diagnostic workup of neuromuscular patients.
Organizational silence and hidden threats to patients’ dignity with schizophrenia: A qualitative study
Authors: Amiri Elham , Ebrahimi Hossein , Habibzadeh Hossein , Baghaei Rahim 
Published: August 2024

Background Maintaining patients’ dignity is a key ethical requirement in healthcare and is emphasized in nursing standards. This issue is particularly significant for patients with schizophrenia because they face unique challenges such as physical and psychological difficulties, dependence on others, and social isolation, making them more vulnerable. Organizational factors can either threaten or preserve their dignity. However, there is little knowledge in this domain within the sociocultural context of Iran. Research Objective This study aimed to explore the role of the healthcare organization in the dignity of patients with schizophrenia, based on the opinions of patients, healthcare personnel, and family caregivers. Research Design This qualitative study was conducted with 26 participants (16 patients, 4 family caregivers, 2 nurses, 3 psychologists, and 1 service worker) who were selected using a purposeful sampling method. The data were collected through semi-structured, in-depth face-to-face interviews until data saturation was reached. The data were analyzed via Graneheim and Lundman’s method. Ethical Considerations The study protocol was approved by the Research Ethics Committee of Urmia University of Medical Sciences (IR.UMSU.REC.1401.099). Findings Based on data analysis, participants reported the three following challenges as organizational hidden threats to patients’ dignity: “Lack of facilities,” “premature management,” and “ineffective communication.” Conclusion The study findings indicated that the healthcare organization does not support the dignity of patients. Management inefficiency and lack of facilities are evident in psychiatric hospitals, and healthcare centers are not monitored based on standard criteria. Limited interactions between healthcare personnel and patients were identified as the main reasons for the neglect of patients with schizophrenia and the violation of their dignity. The results of this study can help healthcare policymakers in designing and implementing effective programs to preserve the dignity of patients with schizophrenia.
Proton pump inhibitors decrease efficacy of palbociclib in patients with metastatic breast
Authors: Álvarez Criado Javier , Zamora Auñon Pilar , Martínez Marín Virginia , GarcíaTrevijano Cabetas Macarena , Collada Sánchez Victoria Lucía , Espinosa Arranz Enrique , Romero-Garrido José Antonio , Benedi-González Juana , Díaz Almirón Mariana , Herrero Ambrosio Alicia 
Published: August 2024

Objectives The objective of this investigation was to assess the impact of concurrent proton pump inhibitors (PPIs) on progression-free survival (PFS) in patients with hormone receptor-positive and HER2-negative metastatic breast cancer (mBC) who received palbociclib as first-line or successives therapy. Materials and Methods A retrospective observational study was conducted, enrolling patients diagnosed with estrogen receptor-positive, human epidermal growth factor receptor 2-negative mBC, and eligible for palbociclib treatment. Patients were categorized as “concurrent PPIs” if they received PPIs for at least two-thirds of the palbociclib therapy duration, and as “no concurrent PPIs” if they did not receive PPIs during the course of palbociclib treatment. Results A total of 165 patients were included in the study. Among first-line patients treated with palbociclib, those using concurrent PPIs exhibited a PFS of 8.88 months, while patients using palbociclib without concurrent PPIs had a PFS of 67.81 months (p < 0.0001). In second-line or subsequent treatments, patients on palbociclib with concurrent PPIs had a PFS of 7.46 months, whereas those using palbociclib without concurrent PPIs had a PFS of 17.29 months (p = 0.122). Conclusion This study demonstrates that the concurrent use of PPIs in mBC patients receiving palbociclib negatively affects PFS, particularly in the first-line setting. Nevertheless, further investigation is warranted to explore the impact of PPIs on cycle-dependent kinase 4/6 inhibitors.
Macular thickness and visual acuity are characterized by a quadratic nonlinear relation in previously treated neovascular AMD eyes
Authors: Borrelli Enrico , Boscia Giacomo , Gelormini Francesco , Ricardi Federico , Ghilardi Andrea , Marolo Paola , Parisi Guglielmo , Fallico Matteo , Lupidi Marco , Mariotti Cesare , Bandello Francesco , Sadda SriniVas , Reibaldi Michele 
Published: August 2024

Purpose To assess the associations between visual acuity (VA) and retinal thickness in age-related macular degeneration (AMD) eyes treated with anti-vascular endothelial growth factor (VEGF) therapy. Methods Sixty-eight patients with neovascular AMD (68 eyes) undergoing anti-VEGF therapy with two years of follow-up imaging data after the initiation of treatment were retrospectively included. Linear and nonlinear regression analyses with curve fitting estimation were performed to explore the relationship between visual acuity and OCT-based parameters at the 3-month and 24-month follow-up visits. Regression analyses were also performed between visual acuity and the retinal thickness deviation which was calculated as the absolute value of the difference between measured and normative retinal thickness values. Results The VA was not associated with either foveal (R2 = 0.011 and p = .401 at 3 months; R2 = 0.032 and p = .142 at 24 months) or parafoveal (R2 = 0.045 and p = .081 at 3 months; R2 = 0.050 and p = .055 at 24 months) retinal thicknesses. Compared with the linear models, a quadratic function yielded a relative increase in the R2 coefficients. Conversely, the VA was linearly associated with foveal retinal thickness deviation (R2 = 0.041 and p = .037 at 24 months) and parafoveal retinal thickness deviation (R2 = 0.062 and p = .040 at 3 months; R2 = 0.088 and p = .014 at 24 months) values. Conclusions Although there was no linear relationship between retinal thickness and VA, a weak but statistically significant linear relationship could be observed when a retinal thickness deviation was considered. This suggests that deviation-based parameters may be beneficial for structure-function correlations in the context of anti-VEGF therapy for neovascular AMD.
Mendelian randomization supports causal effects of inflammatory biomarkers on myopic refractive errors
Authors: Kang Yu-Ting , Zhuang Zhen-Huang , He Xi , Huang Ying , Wang Ning-Li , Huang Tao , Li Shi-Ming 
Published: August 2024

Aims To determine whether inflammatory biomarkers are causal risk factors for more myopic refractive errors. Methods Northern Sweden Population Health Study (NSPHS), providing inflammatory biomarkers data; UK Biobank, providing refractive errors data. 95,619 European men and women aged 40 to 69 years with available information of refractive errors and inflammatory biomakers. Inflammatory biomarkers including ADA, CCL23, CCL25, CD6, CD40, CDCP-1, CST5, CXCL-5, CXCL-6, CXCL-10, IL-10RB, IL-12B, IL-15RA, IL-18R1, MCP-2, MMP-1, TGF-β1, TNF-β, TWEAK and VEGF-A were exposures, and spherical equivalent (SE) using the formula SE = sphere + (cylinder/2) was outcome. Results Mendelian randomization analyses showed that each unit increase in VEGF-A, CD6, MCP-2 were causally related to a more myopic refractive errors of 0.040 D/pg.mL-1 (95% confidence interval 0.019 to 0.062; P = 2.031 × 10-4), 0.042 D/pg.mL-1 (0.027 to 0.057; P = 7.361 × 10-8) and 0.016 D/pg.mL-1 (0.004 to 0.028; P = 0.009), and each unit increase in TWEAK was causally related to a less myopic refractive errors of 0.104 D/pg.mL-1 (−0.152 to −0.055; P = 2.878 × 10-5). Tested by the MR-Egger, weighted median, MR-PRESSO, Leave-one-out methods, our results were robust to horizontal pleiotropy and heterogeneity in VEGF-A, MCP-2, CD6, but not in TWEAK. Conclusions Our Mendelian Randomization analysis supported the causal effects of VEGF-A, MCP-2, CD6 and TWEAK on myopic refractive errors. These findings are important for providing new indicators for early intervention of myopia to make myopic eyesight threatening consequences less inevitable.