bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palynology of the Ordovician Kanosh Shale at Fossil Mountain, Utah
Authors: Vecoli Marco , Beck John H. , Strother Paul K. 
Published: October 2015

AbstractPalynomorph assemblages recovered from the Kanosh Shale at Fossil Mountain, Utah, are dominated by operculate acritarchs and cryptospores with minor smaller acritarchs. The present findings add new data to the largely incomplete knowledge of Ordovician acritarch assemblages from Laurentia, up to now known only from very few localities in North America. These populations contain some species in common with acritarchs from the Canning and Georgina basins in Australia and with assemblages from China; they indicate a Middle Ordovician (Dapingian-Darriwilian) age. The assemblage is lacking many typical marine acritarchs of this age, which, in combination with some cryptospores, is probably reflecting the likelihood of freshwater influence in the Kanosh Basin. This observation is congruent with previous interpretations of the depositional setting of the Kanosh Shale as a shallow water lagoon that supported the deposition of carbonate hardgrounds.Four new taxa are described:Busphaeridium vermiculatumn. gen., n. sp.;Digitoglomus minutumn. gen., n. sp.;Turpisphaera heteromorphan. gen., n. sp.; andVermimarginata barbatan. gen., n. sp. In addition, the abundance of operculate forms has enabled the revision and a new emendation of the genusDicommopallaand clarification of the “opalla” complex. We also propose new and revised suprageneric taxa that emphasize inferred biological differences among acritarch genera. The Sphaeromorphitae subgroup is emended to include forms lacking sculptural elements. Two new informal subgroups are proposed: the Superornamenti and the Operculate Acritarchs. Cryptospores are abundant throughout the sections studied and they appear to be more closely related to the late CambrianAgamachatesTaylor and Strother than to Darriwilian and younger Ordovician cryptospores from Gondwana.
Governance Structure and Related Party Loan Guarantees: The Case of Chinese Family Business Groups
Authors: Chen Xin , Arnoldi Jakob , Na Chaohong 
Published: October 2015

ABSTRACTLoan guarantees to related parties by affiliated subsidiaries within family controlled pyramids form a means by which the controlling family expropriates value from minority shareholders. The controlling family, however, will attempt to escape blame for the behavior. Using a sample of 1785 listed Chinese firms affiliated with family-controlled business groups, we explore how family governance structure affects the use of related party loan guarantees. As hypothesized, we find that affiliates with non-family chairmen, but with family directors or senior executives, issue larger volumes of loan guarantees to related parties, whereas affiliates with family chairmen and those with non-family interlocking chairmen do not. The behavior is moderated by regional institutional development.
The Democratic Reconstruction of the Hegelian State in American Progressive Political Thought
Authors: Emerson Blake 
Published: October 2015

AbstractBoth critics and defenders of the modern American administrative state have recognized the influence of Hegelian ideas upon the American progressives. But existing scholarship on this connection has not delved into the institutional details of Hegelian political theory and its transformation in progressivism. This article traces the continuities and adaptations between Hegelian and American progressive theories of the administrative state through three conceptual pairs: individual rights and social welfare, civil society and the state, and legislation and execution. For both German Hegelian legal scholars and the American Hegelian progressives, these conceptual pairs staked out the basic normative and institutional tensions underlying the modern state. The progressives, however, gave these concepts a democratic interpretation, and thus sought to involve the public at multiple levels of the policy-making process. This Hegelian progressive theory provides a compelling basis for a public philosophy of the contemporary American state.
Knights and Knaves in the English Medical Profession: the Case of Clinical Excellence Awards
Authors: EXWORTHY MARK , HYDE PAULA , MCDONALD-KUHNE PAMELA 
Published: October 2015

AbstractWe elaborate Le Grand's thesis of ‘knights and knaves’ in terms of clinical excellence awards (CEAs), the ‘financial bonuses’ which are paid to over half of all English hospital specialists and which can be as much as £75,000 (€92,000) per year in addition to an NHS (National Health Service) salary. Knights are ‘individuals who are motivated to help others for no private reward’ while knaves are ‘self-interested individuals who are motivated to help others only if by doing so they will serve their private interests.’ Doctors (individually and collectively) exhibit both traits but the work of explanation of the inter-relationship between them has remained neglected. Through a textual analysis of written responses to a recent review of CEAs, we examine the ‘knightly’ and ‘knavish’ arguments used by medical professional stakeholders in defending these CEAs. While doctors promote their knightly claims, they are also knavish in shaping the preferences of, and options for, policy-makers. Policy-makers continue to support CEAs but have introduced revised criteria for CEAs, putting pressure on the medical profession to accept reforms. CEAs illustrate the enduring and flexible power of the medical profession in the UK in colonising reforms to their pay, and also the subtle inter-relationship between knights and knaves in health policy.
Prophylactic HPV vaccination: past, present, and future
Authors: CASTLE P. E. , MAZA M. 
Published: October 2015

SUMMARYHuman papillomavirus (HPV) is the necessary cause of cervical cancer, the fourth most common cancer and cause of cancer-related death in females worldwide. HPV also causes anal, vaginal, vulvar, penile, and oropharyngeal cancer. Prophylactic HPV vaccines based on recombinantly expressed virus-like particles have been developed. Two first-generation, U.S. Food and Drug Administration (FDA)-approved vaccines prevent infections and disease caused by HPV16 and HPV18, the two HPV genotypes that cause approximately 70% of cervical cancer, and one of these vaccines also prevents HPV6 and HPV11, the two HPV genotypes that cause 90% of genital warts. A next-generation vaccine, recently approved by the U.S. FDA, targets HPV16, HPV18, and five additional HPV genotypes that together causes approximately 90% of cervical cancer as well as HPV6 and HPV11. In clinical trials, these vaccines have shown high levels of efficacy against disease and infections caused by the targeted HPV genotypes in adolescent females and males and older females. Data indicate population effectiveness, and therefore cost effectiveness, is highest in HPV-naive young females prior to becoming sexually active. Countries that implemented HPV vaccination before 2010 have already experienced decreases in population prevalence of targeted HPV genotypes and related anogenital diseases in women and via herd protection in heterosexual men. Importantly, after more than 100 million doses given worldwide, HPV vaccination has demonstrated an excellent safety profile. With demonstrated efficacy, cost-effectiveness, and safety, universal HPV vaccination of all young, adolescent women, and with available resources at least high-risk groups of men, should be a global health priority. Failure to do so will result in millions of women dying from avertable cervical cancers, especially in low- and middle-income countries, and many thousands of women and men dying from other HPV-related cancers.
A 16-year-old with ST elevation myocardial infarction: case report and review of the literature
Authors: Hill Dustin , Waldman Adam , Vivek Deepak 
Published: October 2015

AbstractChest pain in young adults presents a unique diagnostic challenge, placing young patients at an increased risk to be misdiagnosed, as this patient population typically does not demonstrate the traditional risk factors associated with cardiovascular disease. This study details the case of a 16-year-old male who presented with new-onset chest pain and ST elevation on electrocardiogram. His history was unremarkable for known cardiac risk factors, but laboratory evaluation demonstrated markedly elevated troponins and electrocardiographic findings confirmed ST-segment elevation myocardial infarction. Coronary angiography demonstrated 100% occlusion of the left anterior descending artery, which was managed with percutaneous transluminal coronary angioplasty, thrombectomy, and bare-metal stenting. The patient had an uneventful recovery. This study examines the major causes of ST elevation myocardial infarction in young adults and reviews the major differences between younger and older myocardial infarction populations with emphasis on risk factor profile, pathophysiological mechanisms, clinical presentation, angiographic findings, and prognosis. This review highlights the need for consideration of a wide differential in younger subsets of the population presenting with chest pain and ST elevation. The implementation of current adult management protocols and guidelines for ST elevation myocardial infarction should not be overlooked due to age. Given the potential for premature death and long-term disability with resulting individual and societal consequences, it is crucial to understand the importance of correct diagnostic evaluation in this clinical scenario.
Identification of Organic Binders in Ancient Chinese Paintings by Immunological Techniques
Authors: Hu Wenjing , Zhang Hui , Zhang Bingjian 
Published: October 2015

AbstractThe identification and localization of organic binders in artworks are big challenges in archaeology and conservation science. Immunological techniques, such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence microscopy (IFM) have the potential to become powerful tools for the analysis of organic materials in ancient samples. In this study, ELISA and IFM techniques were combined to identify chicken ovalbumin, glue from several mammalian species, bovine milk, and fish glue in ancient Chinese painting samples. As binders, egg ovalbumin was found in two painting samples and animal glue was found in three samples, which were dated from the 4th to 8th centuries. The results clearly demonstrate that ELISA and IFM can be used to validate results from ancient samples.
Bacterial diversity and community composition from seasurface to subseafloor
Authors: Walsh Emily A , Kirkpatrick John B , Rutherford Scott D , Smith David C , Sogin Mitchell , D’Hondt Steven 
Published: October 2015

Abstract
We investigated compositional relationships between bacterial communities in the water column and those in deep-sea sediment at three environmentally distinct Pacific sites (two in the Equatorial Pacific and one in the North Pacific Gyre). Through pyrosequencing of the v4–v6 hypervariable regions of the 16S ribosomal RNA gene, we characterized 450 104 pyrotags representing 29 814 operational taxonomic units (OTUs, 97% similarity). Hierarchical clustering and non-metric multidimensional scaling partition the samples into four broad groups, regardless of geographic location: a photic-zone community, a subphotic community, a shallow sedimentary community and a subseafloor sedimentary community (⩾1.5 meters below seafloor). Abundance-weighted community compositions of water-column samples exhibit a similar trend with depth at all sites, with successive epipelagic, mesopelagic, bathypelagic and abyssopelagic communities. Taxonomic richness is generally highest in the water-column O2 minimum zone and lowest in the subseafloor sediment. OTUs represented by abundant tags in the subseafloor sediment are often present but represented by few tags in the water column, and represented by moderately abundant tags in the shallow sediment. In contrast, OTUs represented by abundant tags in the water are generally absent from the subseafloor sediment. These results are consistent with (i) dispersal of marine sedimentary bacteria via the ocean, and (ii) selection of the subseafloor sedimentary community from within the community present in shallow sediment.
miR-429 regulates alveolar macrophage inflammatory cytokine production and is involved in LPS-induced acute lung injury
Authors: Xiao Ji , Tang Jing , Chen Quan , Tang Dan , Liu Meimei , Luo Min , Wang Yan , Wang Jiazheng , Zhao Zhenyu , Tang Chaoke , Wang Deming , Mo Zhongcheng 
Published: October 2015

p38 MAPK (mitogen-activated protein kinase) is a critical regulator in lung inflammation. It can be inactivated by DUSP1 (dual-specificity phosphatase 1) which was identified as a putative target of miR-429. miR-429 mimics directly targeted to the 3′-UTR of the gene encoding DUSP1 may result in the translational attenuation of DUSP1. Moreover, the phosphorylation of p38 MAPK was prolonged after miR-429 mimic treatment. Additionally, miR-429 expression was sensitive to LPS (lipopolysaccharide) stimulation and the miR-429 mimics increased the production of pro-inflammatory cytokines. However, anti-miR-429 reduced the LPS-induced production of pro-inflammatory cytokines. These results provide direct evidence that miR-429 is involved in the LPS-induced inflammatory response. In parallel with miR-429, miR-200b and miR-200c, but not miR-200a or miR-141, shared similar effects. In vivo, LPS induced the expression of miR-429, miR-200b and miR-200c in lung. At the same time, inhibiting these miRNAs by anti-miRNAs attenuated the LPS-induced pulmonary inflammatory response and injury. These findings reveal that miR-429 possesses pro-inflammatory activities and may be a potential therapy target for LPS-induced lung injury.
FOXL2 down-regulates vitellogenin expression at mature stage in Eriocheir sinensis
Authors: Li Qing , Xie Jing , He Lin , Wang Yuanli , Yang Hongdan , Duan Zelin , Wang Qun 
Published: October 2015

Ovarian development in crustaceans is characterized by rapid production of egg yolk protein in a process called vitellogenesis. In the present study, we investigated the involvement of a DEAD (Asp-Glu-Ala-Asp) box RNA helicase 20 (DDX20), forkhead transcription factor (FOXL)2 and fushi tarazu factor (FTZ-F)1 in the regulation of vitellogenesis. Based on ESTs from the testis and accessory gland of Eriocheir sinensis, we cloned the full-length cDNAs of foxl2 and fushitarazu factor 1 (ftz-f1), which include the conserved structural features of the forkhead family and nuclear receptor 5A (NR5A) family respectively. The expression of foxl2 mRNA surged at the mature stage of the ovary, when vtg mRNA swooped, suggesting that foxl2 negatively affects the vitellogenin (VTG) synthesis at this developmental stage. Etoposide (inducing germ cell apoptosis) treatment up-regulated FOXL2 and DDX20 at both the mRNA and the protein levels, primarily in the follicular cells as shown by immunofluorescence analysis. Furthermore, foxl2, ddx20 and ftz-f1 mRNA levels increased significantly with right-eyestalk ablation. Interactions between FOXL2 and DDX20 or FTZ-F1 were confirmed by co-immunoprecipitation and the forkhead domain of FOXL2 was identified as the specific structure interacting with FTZ-F1. In conclusion, FOXL2 down-regulates VTG expression by binding with DDX20 in regulation of follicular cell apoptosis and with FTZ-F1 to repress the synthesis of VTG at the mature stage. This report is the first to describe the molecular mechanism of VTG synthesis in E. sinensis and may shed new light on the regulation of cytochrome P450 enzyme by FOXL2 and FTZ-F1 in vitellogenesis.
Coevolution of parasite virulence and host mating strategies
Authors: Ashby Ben , Boots Michael 
Published: October 2015

SignificanceIt is well understood that parasitism may help to explain the evolution of mating strategies, but host behavior is, in turn, critical to the transmission and therefore the evolution of parasites. Despite this clear reciprocity, we lack a coevolutionary theory of mate choice and parasite virulence. We show how coevolution leads to a wide range of dynamics, including cycling and stable strategies, and that this resolves a key criticism of the role of parasites in mate choice: that parasites will evolve to be avirulent, thus reducing their impact on mating strategies. Coevolution also leads to new predictions for the role of several host and parasite traits on selection for mate choice that will guide future experimental and comparative work.
Chum Salmon Genetic Diversity in the Northeastern Pacific Ocean Assessed with Single Nucleotide Polymorphisms (SNPs): Applications to Fishery Management
Authors: Small Maureen P. , Rogers Olive Serena D. , Seeb Lisa W. , Seeb James E. , Pascal Carita E. , Warheit Kenneth I. , Templin William 
Published: October 2015

Abstract
We examined genetic diversity patterns among 55 collections of Chum Salmon from the northeastern Pacific Ocean using 89 single nucleotide polymorphisms (SNPs). The distribution of Chum Salmon samples extended from the Nass River along the coast of British Columbia and along the coast of Washington as far south as the Columbia River. Chum Salmon represented three previously defined run-groups: fall (primarily), summer, and winter. Genetic variation at SNP loci, as measured by FST, ranged from 0.002 to 0.279 over all collections and averaged 0.062 over all loci. Similar to the genetic patterns detected with microsatellites and allozymes, genetic variation followed a regional structure along geographic distance, with genetic diversity being highest in the north and decreasing southward, then increasing in and near the Columbia River. Within Puget Sound, Washington, genetic variation was structured further according to run timing (fall, summer, and winter) and shared ancestry. Simulations indicated that this suite of SNPs is powerful for identifying regional components in a Chum Salmon mixed fishery. Because of the transferability of SNP data, the growing SNP baseline for Chum Salmon will be useful for multiple agencies managing Chum Salmon around the Pacific Rim.
Received December 19, 2014; accepted May 20, 2015
The Influence of Individual Fish Characteristics on Survival and Detection: Similarities across Two Salmonid Species
Authors: Hostetter Nathan J. , Evans Allen F. , Loge Frank J. , O'Connor Rolland R. , Cramer Bradley M. , Fryer Derek , Collis Ken 
Published: October 2015

Abstract
Trait-selective mortality is of considerable management and conservation interest, especially when trends are similar across multiple species of conservation concern. In the Columbia River basin, thousands of juvenile Pacific salmonids Oncorhynchus spp. are collected each year and are tagged at juvenile bypass system (JBS) facilities located at hydroelectric dams, thus allowing the tracking of population-level performance metrics (e.g., juvenile survival and juvenile-to-adult survival). Several studies have suggested that juvenile salmonid survival is both size dependent and condition dependent, but little is known about trait-selective collection at JBS facilities. Trait-selective collection (e.g., length-based or condition-based selectivity) is particularly important, as inferences to population-level performance metrics may be biased if both the survival and collection processes are influenced by similar characteristics. We used a capture–mark–recapture study to investigate length- and condition-selective survival and detection probabilities for two salmonid species in the Columbia River basin. In 2014, juvenile steelhead O. mykiss (n = 11,201) and yearling Chinook Salmon O. tshawytscha (n = 7,943) were PIT-tagged, measured (FL), examined for external condition characteristics (descaling, body injuries, fin damage, or disease symptoms), and released into the Lower Granite Dam JBS facility on the Snake River to continue seaward migration. Results indicated similar trends in both length- and condition-selective juvenile survival and detection probabilities. For both species, survival probability was higher for longer, nondegraded individuals (those without descaling, body injuries, or fin damage). Trends in detection probability were also consistent across species: shorter, degraded individuals were more likely to be detected at downstream JBS facilities than longer, healthier individuals. These results suggest that similar characteristics (FL and external condition) affect survival and detection processes for PIT-tagged steelhead and yearling Chinook Salmon and that JBS facilities may selectively collect smaller, degraded individuals with lower probabilities of survival. The consistency in trait-selective survival and detection results has important management implications for several species of conservation concern.
Received February 3, 2015; accepted July 20, 2015
A Survey of Steelhead Age and Iteroparity Rates from a Volunteer Angler Program in the Willamette River Basin, Oregon
Authors: Clemens Benjamin J. 
Published: October 2015

Abstract
The iteroparous life history of steelhead Oncorhynchus mykiss can provide genetic variability and increase recruitment, thereby sustaining populations. Steelhead are difficult to survey given that (1) they spawn during high river flows, which can flush carcasses away; (2) they spend a short time on the spawning grounds; (3) nonspawning fish are elusive; and (4) adults that do not die after spawning can evade surveyors. An angler volunteer program was implemented in Oregon to monitor steelhead populations. Recreational anglers collected scales from 2,216 steelhead in the Willamette River basin during 1981–1994; the scales were used to estimate ages and iteroparity rates. A freshwater age of 2 and a saltwater age of 2 were the most common, followed by saltwater ages 3 and 4. The incidence of iteroparity was greater among female steelhead than among males and was greater for winter-run steelhead than for summer-run fish. Wild fish had a higher incidence of repeat spawning than hatchery fish, which may be partly attributable to hatchery practices (e.g., recycling the fish through the fishery or using them for spawning). These results agree with previously published information for steelhead. The overall iteroparity rate of 3.4% for Willamette River basin steelhead appears to be moderate in comparison with other populations; for instance, iteroparity in Willamette River steelhead was much lower than rates for Oregon coastal stocks, was similar to rates for lower Columbia River stocks, and was higher than rates for interior Columbia River stocks. I offer the following hypotheses to explain these geographical trends in iteroparity: (1) Willamette River basin steelhead have a greater distance to migrate than coastal stocks and iteroparity may be selected against by barriers to adult and juvenile passage, (2) similar iteroparity rates for Willamette River basin and lower Columbia River steelhead stocks suggest similarity in migratory conditions, and (3) by contrast, the interior Columbia River stocks have a longer migration distance and also experience challenges associated with the hydropower system.
Received December 12, 2014; accepted July 30, 2015