bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Topical Treatment of Pigmentation Skin Disorders with Plant Hydroquinone Glucosides as Assessed by Quantitative Color Analysis
Authors: Clarys Peter , Barel André 
Published: April 2015

AbstractHydroquinone is a well known reagent used in the treatment of pigmentation disorders. The instability of the quinones and the required active concentration make topical treatment rather difficult. We tested the efficacy of an ascorbate‐phytohydroquinone complex that inhibits the synthesis of melanin and promotes the degradation of the existing melanin. Lentigo senile lesions were evaluated before and after 1 month of treatment. Objective skin color evaluation was performed instrumentally.After one month of treatment, a clear depigmentation of the macules was measured. None of the volunteers reported any side effects from the prolonged treatment with the hydroquinone containing product.
Hormonal Milieu in the Maintenance of Melasma in Fertile Women
Authors: Hassan Iffat , Kaur Inderjeet , Sialy R. , Dash R.J. 
Published: April 2015

AbstractMelasma is a specific type of facial hyperpigmentation seen in women taking oral contraceptives, in non‐pregnant women who have not used oral contraceptives, and in some pregnant women during the progression of gestation, but rarely in men.Circulating LH, FSH, PRL, and E2‐17β on day 5, 7, 9, and 11 of the menstrual cycle and progesterone (P) on day 17, 19, and 21 were measured in thirty‐six ovulating women with melasma (study group) age 25–35 years and twelve healthy controls (control group). Twenty‐seven subjects in the study group had normal pregnancies; 9 others were married or single and had no history of contraceptive pill use. Higher levels of FSH on day 7 (p<0.05); E2‐17β on 5, 7, 9 (p<0.05) and LH on day 9 (p<0.002) were observed in the study group than in the control group. There were no significant differences between the LH/FSH ratio in the two groups. Serum PRL was lower on day 9 in the study group (p<0.05) than in the control group. Serum P was similar in the patients and the controls. These findings indicate a possible role of high E2‐17β in the maintenance of melasma.
Malignant Chondroid Syringoma
Authors: Agrawal Vivek , Gupta Ram L. , Kumar Sharad , Mishra Kiran , Agarwal Sarla 
Published: April 2015

AbstractMalignant chondroid syringoma (MCS) is a rare tumor, of the sweat gland; only a few hundred such cases are reported in literature. A female presented with a subcutaneous swelling on the scalp with repeated recurrence and positive regional lymph nodes. Adequate planning for the treatment of this case was possible as preoperative diagnosis of MCS was documented by fine needle aspiration cytology (FNAC). The case was successfully managed with a multimodal approach, which included radical surgery and subsequent radiotherapy. The patient is symptom free after 25 months. The possibility of this type tumor should be entertained when multiple recurrences occur following adequate excision. FNAC has a definitive role in planning rational therapy.
Subcutaneous Tissue Involvement of CD30‐Positive Large Cell Lymphoma
Authors: Park Seok Beom , Cho Kwang Hyun , Kim Chul Woo 
Published: April 2015

AbstractThere are several types of T‐cell lymphoma presenting with subcutaneous tissue involvement showing different clinical features and prognoses. The entity of subcutaneous involvement of T‐cell lymphoma should be differentiated. We report a case of CD30‐positive large cell lymphoma which initially presented with subcutaneous tissue involvement only, but progressed to systemic dissemination.
Intermittent Therapy for Melasma in Asian Patients with Combined Topical Agents (Retinoic Acid, Hydroquinone and Hydrocortisone): Clinical and Histological Studies
Authors: Kang Won Hyoung , Chun Sei Chung , Lee Sungnack 
Published: April 2015

AbstractMelasma is a common problem in Asians, but treatments have not been satisfactory. In the present study, we evaluated the efficacy of a new formula containing 0.1% tretinoin, 5% hydroquinone, and 1 % hydrocortisone (RHQ) in Korean patients with melasma. Twenty‐five Korean females with therapy recalcitrant melasma applied RHQ on their faces for 4 months and were evaluated before and 4 weeks after treatment clinically and histologically. They were also evaluated clinically 4 months after treatment. To minimize unavoidable side effects (erythema or peeling), we applied RHQ twice a week instead of the usual daily application. However, we obtained clinical and histological results comparable to other reports from white populations. Statistically significant depigmentation in clinical and histological studies and increased subepidermal collagen synthesis were observed in this study. These effects were seen as early as 4 weeks after treatment with RHQ. We used mMASI scoring, a modified version of the original MASI, to quantify the effects of RHQ more objectively and easily.
Immune Thrombocytopenia Due to Tranilast (Rizaben®): Detection of Drug‐dependent Platelet‐associated IgG
Authors: Nagae Shonosuke , Hori Yoshiaki 
Published: April 2015

AbstractTranilast (Rizaben®)‐induced thrombocytopenia occurring in a 17‐year‐old man was reported. After withdrawal of the drug, he recovered within a week with oral prednisolone administration. Serological examination revealed no anti‐platelet antibody, but platelet‐associated IgG (PAIgG) was found. After incubation of peripheral blood of the patient with the drug in vitro, the level of PAIgG was significantly increased. These findings suggest the presence of a drug‐dependent anti‐platelet IgG in the patient's serum. This is the first report of immune thrombocytopenia caused by Tranilast. Our method for detecting drug‐dependent platelet antibody in vitro is safe and useful for diagnosing drug‐induced thrombocytopenia.
Erythema Dyschromicum Perstans: Report of a New Case and Critical Review of the Literature
Authors: Combemale Patrick , Faisant Monique , Guennoc Bernard , Dupin Michel , Heyraud Jean‐Denis 
Published: April 2015

AbstractErythema dyschromicum perstans (EDP), described by Convit et al. in 1961, is a rare dermatosis. Its relationship with ashy dermatosis (AD), described by Ramirez in 1957, is still a matter of debate. We report a typical case of EDP. The patient, of North African origin, had a dyschromic (hypo‐ and hyperpigmented) eruption on the chest and limbs for 2 years. The lesions were occasionally surrounded by a papular border which spread slowly and centrifugally. Histological examination showed a lichenoid infiltrate. A carcinoma of the lung was simultaneously discovered. No treatment was given. EDP is infrequent and often considered identical to ashy dermatosis in the literarure. However, the clinical aspects of the two diseases differ. The main features of these two diseases are reviewed and compared on the basis of a literature review. We conclude that EDP and AD are distinct clinical entities.
Figurate Purpuric Eruptions on the Trunk: Acetaminophen‐induced Rashes
Authors: Kwon Sang Jin , Lee Chang Woo 
Published: April 2015

AbstractA 23‐year‐old man had recurrent erythematous purpuric patches in a transverse‐linear arrangement on his back and arms. One week prior to a recent episode, he took acetaminophen for 3 days. Four months earlier, he developed the same purpuric lesions at/around the same anatomical site when he took acetaminophen for pain‐relief. A biopsy specimen showed capillaritis and extravasation of erythrocytes in the papillary dermis. A provocation test with acetaminophen confirmed these lesions as drug‐induced rashes. The uncommon topographic and morphologic features of the purpuric lesion in this patient might be considered as an unusual expression of pigmented purpuric dermatosis caused by acetaminophen.
Korean Dermatological Association
Authors: Ro Byung In 
Published: April 2015

AbstractThe Korean Dermatological Association (KDA) was founded on October 27, 1945. The first annual meeting was held on November 15, 1947, and meetings have been held twice a year since 1975. The KDA 50th Annual Spring Meeting was on April 15–16, 1998. Korean Journal of Dermatology, the official journal of the KDA, was first published in 1960 and has been published bimonthly since 1978. Annals of Dermatology (Seoul), the English journal, was first published in 1989 and has been published quarterly since 1995. The American residency and specialty board system was introduced in 1954. Board specialty examination of dermatology candidates by the KDA requires four years of residency. Three hundred and twenty residents are now in the training course in the fifty‐nine resident training approved hospitals this year. KDA has seven regional dermatological societies; Seoul, Pusan, Taegu, Honam, Chungchong, Jeonbuk, and Kangwon. KDA has had eleven research subcommittees since 1981. There are two associated societies of the KDA; the Korean Society for Investigative Dermatology was founded in 1991, and the Korean Society for Medical Mycology was founded in 1994. The Korea‐Japan Joint Meeting of Dermatology has been held every two years since 1979 and the Korea‐China Joint Meeting of Dermatology and Mycology has been held since 1996. About three hundred papers were presented at the 49th Annual Autumn Meeting on October 21‐23, 1997. These included special lectures, invited lectures, educational lectures, oral presentations, and posters. About five hundred dermatologists participated in that meeting. KDA joined the International League of Dermatological Societies in 1973 with forty‐seven members. There are around 1200 members of the KDA including 320 residents in 1998.
Pulmonary Function Changes in Patients with Psoriasis on Methotrexate Therapy
Authors: Bedi Gursvaran Kaur , Kaur Inderjeet , Behera Digambar 
Published: April 2015

AbstractMethotrexate is known to induce pulmonary fibrosis. The present study was undertaken to assess pulmonary toxicity, if any, in psoriasis patients on methotrexate therapy and correlate the dose and duration of the treatment with any changes in pulmonary function. Ten patients who had taken methotrexate for one year and ten patients receiving methotrexate were included in the present study. Detailed lung function studies including arterial blood gas analysis were carried out. In both groups, the only pulmonary function abnormalities detected were FEF200–1200, FEF25–75%, residual volume (RV), and RV/TLC%, which showed a decline after six months of treatment. However, this was not significant. No changes were detected in the arterial blood gas values following methotrexate therapy. Therefore, the present study did not find any significant deterioration of lung functions in psoriasis patients on methotrexate therapy.
Detection of Human Herpesvirus 8 in Korean Kaposi's Sarcoma Cases by Polymerase Chain Reaction and In situ Polymerase Chain Reaction
Authors: Jang Ho‐Sun , Park Jung‐Hum , Oh Chang‐Keun , Kwon Kyung‐Sool 
Published: April 2015

AbstractSeveral infectious agents, including herpesvirus‐like particles, had been suggested as possible candidates for the development of Kaposi's sarcoma (KS), and a new herpesvirus, human herpesvirus 8 (HHV‐8), was recently identified in the vast majority of KS lesions, irrespective of their association with human immunodeficiency virus (HIV) infection. However, the etiologic role of HHV‐8 in KS remains controversial. We undertook this study to screen for and localize the presence of HHV‐8 in KS in Korea. A total of 46 paraffin‐embedded specimens were studied, including KS, hemangioproliferative disorders, and 10 non‐KS lesions from HIV‐positive patients. We performed nested polymerase chain reaction (PCR) and in situ PCR with HHV‐8 specific primers. HHV‐8 DNA sequences were detected in 8 of 11 KS specimens. All specimens of hemangioproliferative disorders, non‐KS lesions from HIV‐positive patients, and other skin samples were negative for HHV‐8. When sequencing PCR products, the sequences were almost identical with the prototypic sequence for HHV‐8. In PCR‐positive tissues, in situ PCR staining of HHV‐8 localized to nuclei of endothelial cells and perivascular spindle‐shaped tumor cells. The results of this study suggest that HHV‐8 is not widespread and has a certain causative role in the development of KS. Further studies, including serological and animal studies, will be helpful to appreciate an epidermiological link and pathogenetic mechanism between HHV‐8 and KS.
Erythema Elevatum Diutinum Complicated by Rheumatoid Arthritis
Authors: Nakajima Hideki , Ikeda Mitsunori , Yamamoto Yasuo , Kodama Hajime 
Published: April 2015

AbstractA 53‐year‐old female developed erythema elevatum diutinum (EED) twelve years after the onset of rheumatoid arthritis. The arthritis had been well controlled for the last several years. Annular purpuric macules were characteristically complicated by common nodular and plaque lesions. Both leukocytoclastic vasculitis and fibrosis were observed in the macular lesions, indicating that the lesions were a manifestation of an early phase of EED. Both types of skin lesions disappeared with treatment with dapsone. They have not relapsed for two years after stopping the dapsone. The leukocytoclastic vasculitis was thought to have developed independently of the rheumatoid arthritis. She had noticed sicca symptoms two years before the appearance of EED, but she did not satisfy the diagnostic criteria for Sjögren's syndrome.
Low‐Dose Intravenous Immunoglobulin Therapy for Intractable Dermatomyositis Skin Lesions
Authors: Sadayama Takahiro , Miyagawa Sachiko , Shirai Toshihiko 
Published: April 2015

AbstractWe report a 45‐year‐old female patient with dermatomyositis whose corticosteroid‐resistant cutaneous manifestations improved with low‐dose (0.1 g/kg body weight/day for 5 days weekly for 2 weeks) intravenous immunoglobulin (IVIG) therapy.
Methotrexate Nodulosis
Authors: Jang Kyoung‐Ae , Choi Jee‐Ho , Moon Kee‐Chan , Yoo Bin , Sung Kyung‐Jeh , Koh Jai‐Kyoung 
Published: April 2015

AbstractMethotrexate (MTX) nodulosis in patients with rheumatoid arthritis treated with MTX has become a well recognized phenomenon. It has not been described in patients receiving MTX for treatment of other diseases, e.g., dermatological or malignant diseases. Recently, MTX nodulosis was described in a patient with psoriasis and arthritis. The pathophysiology and treatment of MTX nodulosis are yet unsettled. We experienced a case with dermatomyositis who developed multiple subcutaneous nodules after treatment with MTX. In our patient, numerous, small, symmetrically distributed, grouped subcutaneous nodules were seen on a V‐shaped area of the anterior chest, both axillary areas, and the medial sides of both upper arms and thighs. We histopathologically examined a nodule and started treatment with hydroxychlroquine after discontinuation of MTX. The histopathology revealed septal panniculitis, and the nodules have been under regression.MTX nodulosis may be a drug‐specific phenomenon. Discontinuation of MTX and replacement with hydroxychloroquine are recommended in severe cases. Awareness of this entity is important for diagnosing and treating cases of multiple nodules developing after the administration of MTX, which is widely used for many dermatological diseases.
Immunohistochemical Study of ACTH and α‐MSH in Vitiligo Patients Successfully Treated with a Sex Steroid‐Thyroid Hormone Mixture
Authors: Ichimiya Makoto 
Published: April 2015

AbstractWe previously reported that a sex steroid‐thyroid hormone (Metharmon‐F®; MF, 2 tablets daily) was a potent drug for treatment of vitiligo. Using five patients with generalized vitiligo who were successfully treated with oral administration of MF, we performed an immunohistochemical analysis to elucidate its action mechanism at the cellular level. Histopathologically, the repigmented skin after the treatment showed increased numbers of melanocytes and melanin granules. Immunohistochemically, there was little significant difference between the depigmented lesion before treatment and the repigmented lesion after treatment in terms of the reactivity to adrenocorticotropic hormone (ACTH) and α‐melanocyte‐stimulating hormone (α‐MSH) in keratinocytes. The immunoreactivity to ACTH in melanocytes both before and after the treatment was minimal, but α‐MSH in melanocytes became much stronger after the treatment, than before the treatment. The efficacy of MF in treatment of vitiligo was proven to be due to the stimulatory effect of melanocyte proliferation and melanin production via α‐MSH.
Erythroderma in Children: A Clinico‐Etiological Study
Authors: Sarkar Rashmi , Sharma Ravi C. , Koranne Ravindra V. , Sardana Kabir 
Published: April 2015

AbstractAlthough there are various published studies on erythroderma from western and Asian countries, most of them have only included patients in the adult age groups. As we have an exclusively pediatric dermatology unit, we thought it would be intriguing to study the clinical, etiological and laboratory parameters of erythroderma in children.Seventeen erythroderma patients of both sexes were inducted into the study between 1993 to 1998. The mean age of onset was 3.3 years and the male:female ratio was 0.89:1. Eight (47%) of the patients were infants; 9 (53%) others belonged to the preschool and school going age group (age range between 1 to 12 years). An acute onset of the disease was seen in 47% of the patients while 53% of the patients had a chronic onset.The main presenting complaints were itching in 41% and burning in 18% of patients. Scalp involvement (71%), nail involvement (18%), and alopecia (6%) were the main cutaneous features observed while fever (53%), tachycardia (53%), pedal edema (12%), lymphadenopathy (18%), and hepatomegaly (12%) were the main systemic features observed in this study.Etiologically, drugs (29%) showed the highest incidence, followed equally (18%) by genodermatoses, psoriasis, and staphylococcal scalded skin syndrome (SSSS). Two (12%) patients had erythroderma due to atopic dermatitis, while one was (5%) due to infantile seborrheic dermatitis coexisting with dermatophytosis. Laboratory parameters contributed little towards diagnosis of the underlying dermatological condition. Thus, though erythroderma is a striking entity, it is yet uncommon in the pediatric age group. Because the drug induced group was the largest in this study, we recommend that drugs should be suspected as important causative factors of erythroderma in children.
Encapsulated Necrosis Associated with Behçet's Syndrome
Authors: Takeda Ushio , Kuroda Kei , Shinkai Hiroshi 
Published: April 2015

AbstractWe reported a case of a 45‐year‐old woman with encapsulated necrosis associated with Behçet's syndrome. The lesions were characterized by multiple, small subcutaneous nodules on the extremities. Histologically, a nodule consisted of degenerative adipocytes encapsulated by fibrous tissue. A membranocystic lesion was also observed in the cavity of the nodule. The patient had a long‐term history of Behçet's syndrome and suffered from erythematous subcutaneous nodules, resembling erythema nodosum on the extremities with a tendency to recurrence. These observations indicate that Behçet's syndrome could be implicated in the development of encapsulated necrosis as an underlying disease.
A Case of Multiple Subungual Glomus Tumors Associated with Neurofibromatosis Type 1
Authors: Okada Osamu , Demitsu Toshio , Manabe Motomu , Yoneda Kozo 
Published: April 2015

AbstractGlomus tumor is a distinctive neoplasm characterized by the presence of cells that resemble the modified smooth muscle cells of the normal glomus body, which is a specialized form of arteriovenous anastomosis. We report a case of multiple subungual glomus tumors associated with neurofibromatosis and review the literature on the pathophysiology of this association.
Keratoacanthoma Centrifugum Marginatum Arising from a Scar after Skin Injury
Authors: Watanabe Daisuke , Tachi Naoko , Tomita Yasushi 
Published: April 2015

AbstractAmong the variants of solitary keratoacanthoma, keratoacanthoma centrifugum marginatum (KCM) is characterized by the lack of a tendency toward spontaneous remission and by continuous centrifugal spread. We describe a case of KCM arising from the scar after an old skin injury. The lesion appeared on the dorsum of the right hand, grew peripherally for 30 months, and became a tumor with a multinodular margin and central atrophy. A biopsy specimen from the edge of the tumor showed features resembling typical solitary keratoacanthoma.
Differentiation of Malignant Lymphoma and Non‐Lymphoma by an Occlusive Dressing Method Employing Bromodeoxyuridine
Authors: Ohtake Naoki , Kanzaki Tamotsu , Nakano Ritsuko 
Published: April 2015

AbstractAlthough lymphoma cells can proliferate in skin tissue, lymphocytes which have infiltrated the skin due to inflammatory changes are generally unable to do so. It may be possible to differentiate malignant lymphomas from benign lymphocytic infiltrations in skin tissue by detection of cell cycle‐related antigens. We developed a novel in vivo method for studying the cell kinetics of human skin using bromodeoxyuridine (BrdU) with an occlusive dressing. Following the application of BrdU, BrdU‐labeled lymphoid cells were counted in the dermis. The patients studied included 22 with various types of lymphomas (lymphoma group) and 22 with different forms of inflammatory skin disease (non‐lymphoma group). Skin specimens were obtained after applying occlusive adhesive plasters containing 2% BrdU dissolved in 0.9% sodium chloride solution and were then immunostained with anti‐BrdU monoclonal antibody. The average percentages of labeled cells were 15.9 ± 7.6% for the lymphoma group and 4.7 ± 2.6% for die non‐lymphoma group. This difference was statistically significant (p<0.0001). Using this method, malignant lymphomas and benign lymphocytic infiltrations of the skin could be differentiated by counting BrdU‐labeled lymphoid cells, and this method could help in determining a prognosis.
Malassezia spp Carriage in Patients with Seborrheic Dermatitis
Authors: Pechère Marc , Krischer Joachim , Remondat Catherine , Bertrand Catherine , Trellu Laurence , Saurat Jean‐Hilaire 
Published: April 2015

AbstractThe role of Malassezia spp in seborrheic dermatitis (SD) is controversial. To compare the cutaneous density and the cultural characteristics of Malassezia in persons with or without SD, quantitative cultures were obtained by stripping the forehead with a tape placed on Leeming and Notman medium. Plates were incubated at 37°C in a plastic bag, and colonies were counted after 14 days. High yeast density was defined as >100 colony forming units (CFU)/tape. Volunteers were divided into four groups depending on their HIV serology [HIV (+) versus HIV (‐) or unknown] and their clinical status (with or without SD). 126/129 cultures were positive (97.7%). Malassezia spp density was low on clinically normal skin in all HIV (‐) persons (40/40) but was high in 8/34 (24%) HIV (+) persons without SD (p<0.001). In SD patients, high densities were found in 10/22 (45%) HIV (+) and in 17/33 (52%) HIV (‐) persons. The strains could be divided into three basic groups on the basis of their cultural characteristics. Colony morphology type A predominated on normal skin (72%), and morphology type C predominated on persons with SD (78%). High yeast density can be present without skin symptoms. The pathogenicity of Malassezia seems more likely to be determined by the subtype present on the skin rather than by its density.