bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between periodontitis and cardiovascular risk in Spanish employed adults—The Workers' Oral Health study
Authors: Molina Ana , Martínez María , Montero Eduardo , Carasol Miguel , Herrera David , Figuero Elena , Sanz Mariano 
Published: August 2024

AbstractAimsPeriodontitis and cardiovascular diseases (CVD) are highly prevalent non‐communicable diseases, sharing an inflammatory pathogenesis and common risk factors. The objective of the present research is to assess the association between periodontitis and cardiovascular disease risk in a representative sample of the Spanish‐employed population.MethodsCross‐sectional data were obtained between 2008 and 2011 in the Workers' Oral Health (WORALTH) epidemiological study. Periodontal examinations were based on the evaluation of clinical attachment loss (CAL) and community periodontal index (CPI). Participants also underwent a medical check‐up and answered a comprehensive health questionnaire. With this information, participants were categorized into three levels of CVD risk using the systemic coronary risk estimation (SCORE) algorithm for low‐risk European countries. Crude and adjusted odds ratios (ORs) were determined with multiple logistic regression models for the association between periodontal status and CVD risk.ResultsData from 4224 individuals were analyzed. The overall prevalence of high CVD risk (SCORE ≥ 5%) was 5.1%. The prevalence of SCORE ≥ 5% was 3.4%, 9.4%, and 15.2% for CAL 0–3 mm, 4–5 mm, and ≥6 mm, respectively (p < .001), and 6.2%, 6.5%, and 14.6% for CPI ≤2, 3, and 4, respectively (p < .001). Individuals with CPI = 4 presented an OR of 1.50 (95% confidence interval, CI [1.04; 2.17]) for high SCORE values, after adjusting for confounders (age, sex, and smoking habit).ConclusionsPeriodontitis, defined by the presence of deep periodontal pockets (≥6 mm), was significantly associated with high CVD risk (SCORE ≥ 5%) in a representative sample of the employed population in Spain.
Methods for causality assessment of idiosyncratic drug‐induced liver injury
Authors: García‐Cortés Miren , Matilla‐Cabello Gonzalo , Lucena M. Isabel 
Published: August 2024

AbstractThe diagnosis of idiosyncratic drug‐induced liver injury (DILI) is a challenging task due to the lack of specific features or definitive diagnostic tools. A minimum of clinical and pharmacological information is required, together with laboratory and imaging tests to exclude other causes of liver injury. Several standardized methods have been developed to support clinical judgement and establish causality assessment, the most widely used being the Roussel Uclaf Causality Assessment Method—RUCAM—and structured Expert Opinion. More recently, an evidence‐based, revised RUCAM, Electronic Causality Assessment Method—RECAM—has been developed and, although still a work in progress, may replace RUCAM scoring in the future. International collaborative networks and ongoing research efforts are key to advancing biomarker qualification and validation and developing new in vitro patient‐based methods that will help improve DILI diagnosis and move towards a personalized medicine approach.
Using input‐output data to model the structure of export linkages in global value chains: A Brazil case study
Authors: Trigg Andrew B. , Villani Davide , Leite Fabrício Pitombo , Perraton Jonathan R. 
Published: August 2024

AbstractThis paper considers Global Value Chains by developing an open Leontief input‐output model for which household consumption is endogenously determined—the Type II framework. Three specific contributions are: an extension of the Type II input‐output model to a multi‐country setting; its empirical modelling using trade‐linked input‐output tables; and a Brazil case study for exploring how the industrial structure of export linkages impact on employment. Policy dilemmas that emerge for Brazil's industrial strategy focus on its heavy reliance on primary‐based industries, and how it might diversify its trading partners.
The OsGAPC1‐OsSGL module negatively regulates salt tolerance by mediating abscisic acid biosynthesis in rice
Authors: Jiang Lingli , Xiao Weiyu , Chen Huiping , Qi Yinyao , Kuang Xinyu , Shi Jiahui , Liu Zhenming , Cao Jianzhong , Lin Qinlu , Yu Feng , Wang Long 
Published: August 2024

Summary

Plants frequently encounter adverse conditions and stress during their lives. Abscisic acid (ABA) plays a crucial role in response to salt stress, and dynamic regulation of ABA levels is essential for plant growth and stress resistance.

In this study, we identified a transcription factor, OsSGL (Oryza sativa Stress tolerance and Grain Length), which acts as a negative regulator in salt stress, controlling ABA synthesis. OsSGL‐overexpressing and mutant materials exhibited sensitivity and tolerance to salt stress, respectively. Notably, under salt treatment, several ABA‐related genes, including the ABA synthesis enzyme OsNCED3 and the ABA response gene OsRAB21, were bound by OsSGL, leading to the inhibition of their transcription.

Additionally, we found that a key enzyme involved in glycolysis, OsGAPC1, interacted with OsSGL and enhanced the inhibitory effect of OsSGL on OsNCED3. Upon salt stress, OsGAPC1 underwent acetylation and then translocated from the nucleus to the cytoplasm, partially alleviating the inhibitory effect of OsSGL on OsNCED3. Identification of the OsGAPC1‐OsSGL module revealed a negative regulatory mechanism involved in the response of rice to salt stress.

This discovery provides insight into the dynamic regulation of ABA synthesis in plants under salt stress conditions, highlighting the delicate balance between stress resistance and growth regulation.
DkDTX1/MATE1 mediates the accumulation of proanthocyanidin and affects astringency in persimmon
Authors: Liu Ying , Sun Chenfeng , Wu Xin , Chen Wenxing , Luo Zhengrong , Xu Liqing , Zhang Qinglin 
Published: August 2024

AbstractProanthocyanidins (PAs) is a kind of polyphenols widely distributed in plants, and their astringent properties can protect plants from herbivores and regulate fruit taste. There is a great difference in PA composition between astringent (A)‐type and nonastringent (NA)‐type persimmon. Here, we studied the potential of DkDTX1/MATE1 in regulating PAs composition through its preferred transport in persimmon fruit. The results of fluorescence microscope showed that the DkDTX1/MATE1 green fluorescence overlapped with the blue light emitted by PA. Overexpression of DkDTX1/MATE1 in persimmon leaves not only significantly increase the concentrations of PA, but also upregulated the expression of PA biosynthesis pathway genes. Further overexpression of DkDTX1/MATE1 in persimmon fruit discs and stable genetic transformation of DkDTX1/MATE1 also led to PA concentrations increased. Molecular docking and transporter assays showed that DkDTX1/MATE1 preferentially transported catechin, epicatechin gallate and epigallocatechin gallate. DkDTX1/MATE1 mainly bound to the PA precursors via serine at position 68. Our findings indicate that DkDTX1/MATE1 play a role in the accumulation of PAs in early stage of fruit development and affects the astringency of persimmon through preferential transport PA precursors, which provided a theoretical basis for the future use of metabolic engineering to regulate the composition of PAs in persimmon.
A Rare Case of Refractory Nodal Marginal Zone Lymphoma in a Child, Successfully Cured by Allogeneic Stem Cell Transplant: A Case Report
Authors: Memon Shahbaz , Almudayfir Ziyad , Elbashir Enas , Taher Leena , Rogi Fayhan , Essa Mohammad 
Published: August 2024

ABSTRACTBackgroundNodal marginal zone lymphoma (NMZL) is a rare form of non‐Hodgkin lymphoma (NHL), accounting for around 2% of all NHL in pediatrics and adults. It is considered the least common subtype of marginal zone lymphoma, which is rarely seen in pediatrics and is usually viewed as a mild disease. In adults, its presentation varies from mild to aggressive disease with multiple lymph node enlargement and systemic symptoms.Case ReportHere, we report an interesting case of a 31‐month‐old boy who developed refractory EBV‐positive NMZL with extensive disease. The tumor did not respond well to conventional chemotherapy and Rituximab. Therefore, we manage the disease with second‐line chemotherapy, including bortezomib, followed by an allogeneic hematopoietic stem cell transplant (HSCT) with an excellent outcome.ConclusionVery few cases have been reported for aggressive NMZL children. The tumor was refractory to first line chemotherapy. However, the successful outcome was achieved by allogeneic stem cell transplant with myeloablative conditioning chemotherapy. The significance of this particular case is that this is the first reported case from pediatrics for refractory NMZL, which responded well to allogeneic stem cell transplant.
Phototherapy for the treatment of cutaneous graft‐versus‐host disease: A systematic review
Authors: Fachler‐Sharp Tahel , Kobal Inbar , Sheffer‐Levi Sivan , Cohen Adiel , Hassidim Ayal , Molho‐Pessach Vered , Shreberk‐Hassidim Rony 
Published: August 2024

AbstractBackgroundCutaneous graft‐versus‐host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation. Phototherapy has been used to treat cutaneous GVHD, but data on its safety and efficacy are sparse.AimReview the current medical literature regarding the efficacy, dosing, and safety of various types of phototherapies for the treatment of cutaneous GVHD.MethodsA systematic review of PubMed, Embase, Cochrane, and ClinicalTrials databases was performed. Publications were screened according to the PRISMA guidelines. Exclusion criteria comprised case reports and case series reporting less than five patients, review articles, and articles not published in English.ResultsA total of 28/1304 (2.5%) studies were included. Fifteen studies (n = 267 patients) focused on psoralen and ultraviolet (UV) A (PUVA), in which 65.5% of patients received concomitantly other systemic treatments. The response rate was 89.9%, with a mean of 33.2 treatments. Adverse events were recorded in 54% but were mainly mild. Eight studies, encompassing 95 patients, focused on narrow‐band (NB) UVB. A response was observed in 94%, with a mean number of 26 treatments and 8.6% adverse effects. UVA1 was reported in six studies (n = 132 patients). A response was recorded in 89.3% with a mean of 26.2 treatments. Adverse events were noted in 70.1%, with a discontinuation rate of 10.9%. It should be noted that adverse events were recorded during the follow‐up period of the studies, which varied significantly, ranging from no follow‐up to 31 months.ConclusionsCurrent data regarding the use of phototherapy for the treatment of cutaneous GVHD are based on retrospective studies and case series. The present report advocates the use of one of the three modalities of phototherapy as an effective and safe adjunctive treatment for cutaneous GVHD, especially NB UVB phototherapy.
Associations of Wearable Ring Measured Sleep, Sedentary Time, and Physical Activity With Cardiometabolic Health: A Compositional Data Analysis Approach
Authors: Niemelä Maisa , Maijala Anna , Nauha Laura , Jämsä Timo , Korpelainen Raija , Farrahi Vahid 
Published: August 2024

ABSTRACTMovement behaviors within the 24‐h day, including physical activity (PA), sedentary time, and sleep, are associated with cardiometabolic health. We aimed to determine the association between 24‐h movement composition and cardiometabolic health while accounting for sleep efficiency. Altogether, 1134 participants from the Northern Finland Birth Cohort 1986 study, free from prior cardiovascular disease, provided at least 4 days of 24‐h activity and sleep efficiency measured with a wearable ring. Participants' body composition was assessed with bioimpedance, blood pressure, and waist circumference were measured, and lipids and glucose were analyzed from a fasting blood sample. Linear regression models for cardiometabolic outcomes were created with 24‐h movement composition and covariates, including sleep efficiency and behavioral and socioeconomic factors. Isotemporal time reallocations were used to demonstrate the dose‐dependent associations between time use and outcomes. Beneficial associations with the outcomes were detected when sedentary time was reallocated to light PA, moderate‐to‐vigorous PA (MVPA), or sleep. For example, substituting 30 min of sedentary time with MVPA was associated with 7.2% (95% CI from −9.8% to −4.5%) lower visceral fat area, 4.9% (95% CI from −6.5% to −3.3%) lower body fat percentage, 1.6% (95% CI from −2.3% to −0.9%) smaller waist circumference, and 2.4% (95% CI from 1.2% to 3.5%) higher high‐density lipoprotein (HDL) cholesterol after accounting for gender, marital status, education level, employment, smoking, alcohol consumption, and sleep efficiency. Substituting sedentary time with sleep or light PA showed beneficial but smaller differences in adiposity measures and HDL cholesterol. Limiting sedentary time should be encouraged in adulthood.
In vitro efficacy of Rosa damascena solid state fermentation liquid and water extract on skin care
Authors: Chen Zhixiong , Hong Ni , Xu Nuo , Yan Cui , Cao Ping , Yao Hong 
Published: August 2024

AbstractBackgroundAs a medicinal and food homologous plant, Rosa damascena is not only highly ornamental, but also rich in a variety of active ingredients such as polyphenols and flavonoids. It is widely used in cosmetics, food and pharmaceutical industries.ObjectiveTo study the in vitro efficacy of Rosa damascena solid state fermentation liquid (RDF) and water extract (RDE).MethodsFirstly, the effect of RDF and RDE on the proliferation rate of B16F10 cells was detected by CCK‐8 method, and the melanin content was measured by sodium hydroxide lysis method to evaluate the whitening effect of them. Finally, the antioxidant, anti‐wrinkling and soothing effects of RDF and RDE were evaluated by biochemical methods in vitro.ResultsRDF and RDE within a certain concentration range (0.05%–0.5%) had no effect on the proliferation of B16F10 cells. Compared with Rosa damascena extract (RDE), RDF showed significant effects on bleaching, antioxidant, anti‐wrinkling and soothing, among which 0.5% RDF showed the best effect.ConclusionBoth RDF and RDE at a certain concentration have effect on skin care in vitro, but the effect of RDF is more significant than that of RDE.
Phosphate deficiency alters transcript isoforms via alternative transcription start sites
Authors: Reis Rodrigo S. , Clúa Joaquín , Jaskolowski Aime , Deforges Jules , Jacques‐Vuarambon Dominique , Guex Nicolas , Poirier Yves 
Published: August 2024

SUMMARYAlternative transcription start sites (TSS) are widespread in eukaryotes and can alter the 5′ UTR length and coding potential of transcripts. Here we show that inorganic phosphate (Pi) availability regulates the usage of several alternative TSS in Arabidopsis (Arabidopsis thaliana). In comparison to phytohormone treatment, Pi had a pronounced and specific effect on the usage of many alternative TSS. By combining short‐read RNA sequencing with long‐read sequencing of full‐length mRNAs, we identified a set of 45 genes showing alternative TSS under Pi deficiency. Alternative TSS affected several processes, such as translation via the exclusion of upstream open reading frames present in the 5′ UTR of RETICULAN LIKE PROTEIN B1 mRNA, and subcellular localization via removal of the plastid transit peptide coding region from the mRNAs of HEME OXYGENASE 1 and SULFOQUINOVOSYLDIACYLGLYCEROL 2. Several alternative TSS also generated shorter transcripts lacking the coding potential for important domains. For example, the EVOLUTIONARILY CONSERVED C‐TERMINAL REGION 4 (ECT4) locus, which encodes an N6‐methyladenosine (m6A) reader, strongly expressed under Pi deficiency a short noncoding transcript (named ALTECT4) ~550 nt long with a TSS in the penultimate intron. The specific and robust induction of ALTECT4 production by Pi deficiency led to the identification of a role for m6A readers in primary root growth in response to low phosphate that is dependent on iron and is involved in modulating cell division in the root meristem. Our results identify alternative TSS usage as an important process in the plant response to Pi deficiency.
The Prevalence of Tick‐Borne Encephalitis Virus Infection Among Humans in Heilongjiang Province of China in 2020–2023
Authors: Chen Denghui , Lu Yaxian , Wang Wei , Zhang Yu , Liu Tianlu , Liu Hetong , Zhang Lu , Peng Xiaohong , Lv Shouxu , Wang Zedong , Wu Wenzhong , Hou Zhijun 
Published: August 2024

ABSTRACTBackground and AimsTick‐borne encephalitis (TBE) is a serious and acute central nervous system infection caused by the tick‐borne encephalitis virus (TBEV). In recent years, TBE has emerged as a growing public health threat, with cases reported across Europe, the Russian Far East, Japan and China. This study aims to assess the prevalence of TBEV infection and examine behaviours associated with an increased risk of infection among individuals who visited the Heilongjiang Red Cross Sengong General Hospital due to tick bites from 2020 to 2023.Methods and ResultsWe collected blood samples and administered survey questionnaires from tick‐bitten people. A total of 457 samples were screened using Nested PCR, and the detected TBEV prevalence rate was 29.54% (135/457). The symptoms of redness and swelling at the site of tick bite (42.57%), fever (28.71%) and headache (10.89%) were identified in the TBEV‐positive individuals when they visited the hospital by the physician. Phylogenetic analysis of the partial E gene of TBEV revealed that the predominant strains in the region are highly virulent Far Eastern subtype. However, they do not cluster with the three established evolutionary clades of the Far Eastern type. Questionnaires data analysis identified age and first tick bite as important factors associated with TBEV infection.ConclusionsThis study provides basic information on the epidemiology of TBEV in Heilongjiang Province in recent years and identifies that the most related risk factor of infecting TBEV is tick exposure. Further research is needed to develop effective prevention and control measures.
A Solution Method for the Filtered Lifting Line Theory
Authors: Martinez-Tossas Luis A. , Allaerts Dries , Branlard Emmanuel , Churchfield Matthew J. 
Published: August 2024

Abstract
The filtered lifting line theory presents a continuous form of the inviscid momentum equations of flow over a lifting device, such as a wing or rotor blade, using body forces without mathematical singularities. This theory is also consistent with an actuator line representation of a lifting device. In this work, we present a reformulation of the equations in terms of the local flow angle along the line, which allows solving the stand-alone equations using multivariate root-finding algorithms. This approach can be used to obtain a fast, computationally inexpensive solution of the loading distribution along a wing without the need to perform computational fluid dynamic simulations. We study the requirements in terms of resolution in the spanwise direction and establish the criteria for spacing and minimum amount of points required along the blade to obtain converged solutions. The solutions are compared to results from large-eddy simulations, and we observed excellent agreement with less than a percent difference in quantities along the blade between the methods.
Exploring community- and systemic-level gender-based violence in visible minority women across five countries from an intersectionality lens: protocol for a mixed-methods systematic review
Authors: Chowdhury Nashit , Erman Didem , Raihan Mohammad , Marshall Zack , Datta Ranjan , Aghajafari Fariba , Shankar Janki , Sehgal Kamal , Rashid Ruksana , Turin Tanvir C 
Published: August 2024

IntroductionThe intersection of sexism with racism and xenophobia disproportionately exposes visible minority women to gender-based violence (GBV) at the community and systemic levels. This study aims to understand the knowledge strengths and gaps on GBV against visible minority women with an intersectional lens, revealing systemic barriers to accessing support and how these barriers intensify GBV and its effects. It will also identify effective and ineffective policies and practices in the literature to develop strategies addressing the root causes of GBV and supporting survivors.Methods and analysisWe will conduct a mixed-methods systematic review using a convergent integrated approach to examine current literature on community- and systemic-level GBV against visible minority women. We will follow Joanna Briggs Institute’s guidelines to converge data from both qualitative and quantitative studies to obtain an integrated qualitative synthesis on GBV in five countries: Canada, the USA, the UK, Australia and New Zealand. This analysis will be conducted following Thomas and Harden’s thematic synthesis guidelines. Community members with lived experience of GBV will actively contribute to improving the relevance and interpretation of results, following a community-engaged research approach. Themes are expected to unveil various aspects of community- and systemic-level GBV due to the intersection of racism, xenophobia and sexism, alongside barriers in addressing GBV and research gaps.Ethics and disseminationSince this study does not involve primary data collection or the use of identifiable human data, no ethical approval will be needed. Results will be disseminated through integrated knowledge translation, involving collaboration with participants who have lived experience of GBV. The findings will be used to identify specific areas of policy intervention, including adopting culturally sensitive approaches, improving school and workplace policies and promoting rights of visible minority women.
Scoping review of healthcare professionals’ views on intimate partner violence in the Middle East and North Africa
Authors: Al-Salmi Sabrina , Aly Farah W , Najeeb Farah S N , Shaikh Zoya , Zuaiter Farah A O A , Doherty Sally , Sefen Jessica Atef Nassef 
Published: August 2024

ObjectivesThis scoping review aims to survey healthcare providers (HCPs) in the Middle East and North Africa (MENA) about their knowledge, attitudes and barriers to working with women who have experienced intimate partner violence (IPV). This review aims to map the breadth of available peer-reviewed literature that may inform future educational training programmes.DesignScoping review.Data sourcesThe scoping review included studies up to December 2023 from PUBMED, Medline, COCHRANE, Cumulative Index of Nursing and Allied Health Literature, PsycINFO and Arabic medical journals.Eligibility criteriaSelected articles were restricted to those carried out in the MENA region, available in full text and with no date restrictions.Data extraction and synthesisData were extracted from all studies to include research location, year of publication, type of journal, methodology, design, participants, knowledge, attitudes and barriers. By charting the information into a table, the data were analysed using frequency, counts and descriptive content analysis.ResultsOf the 1060 articles reviewed, 29 eligible studies were included in this scoping review. 27% of the articles reported HCPs’ lack of knowledge about IPV protocols. The dominant attitude reported was a preference to treat the presenting health complaint and avoid discussing IPV. Finally, 30% of articles reported HCPs’ lack of training as the main barrier.ConclusionOur paper concluded that there is a lack of research in understanding the knowledge, attitudes and barriers surrounding HCPs in the MENA region and IPV. This scoping review highlights the need for further research, informed interventions and training for HCPs in the region.