bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acromegaly and pregnancy: a prospective study
Authors: Dias Monike , Boguszewski Cesar , Gadelha Monica , Kasuki Leandro , Musolino Nina , Vieira Jose G H , Abucham Julio 
Published: November 2013

Context and objectiveThe interaction between pregnancy and acromegaly has been studied only retrospectively. We used prospective data to assess those interactions.DesignProspective, interventional, multicentric study.PatientsTen pregnancies in eight acromegalic patients were included according to the following criteria: previous diagnosis of acromegaly; and active acromegaly before pregnancy. Sellar magnetic resonance image (MRI), GH, and IGF1 measurements were carried out before pregnancy. The exclusion criterion was radiotherapy.InterventionWithdrawal of pharmacological treatment (octreotide and/or cabergoline and/or pegvisomant) following pregnancy diagnosis.Main outcome measuresClinical/biochemical evaluations throughout pregnancy/puerperium and sellar MRI after delivery; and GH and IGF1 measurements before pregnancy. GH was measured by an interference-free IFMA assay during pregnancy and IGF1 by measured by Immulite 2000 assay in patients and 64 control pregnancies.ResultsNo tumor growth was observed. Nine deliveries were at term and one at 35 weeks (preeclampsia). All newborns were healthy. Mean IGF1 levels before and during pregnancy were similar, but increased significantly during puerperium. As IGF1 in controls increased after midgestation, the prevalence of controlled IGF1 rose significantly from 2/10 (<20 weeks) to 9/10 (>30 weeks). Diabetes mellitus and hypertension/preeclampsia developed in one patient in each group; both complications were nonsignificantly (P=0.06) associated with IGF1 >1.3 ULN before pregnancy.ConclusionsAcromegaly control usually improved and tumor growth was not stimulated during pregnancy in spite of withdrawal of drug treatment. Drug treatment can be discontinued in most patients. Uncontrolled disease before pregnancy may pose a higher risk for diabetes and hypertension.
A Calorimetric Method for Determination of Heat Capacity of Ceramics for Concentrated Solar Thermal Systems / Skenējošās Kalorimetrijas Metode Siltumietilpības Noteikšanai Saules Kolektoru Keramikā
Authors: Kalnačs J. , Grehovs V. , Mežinskis G. , Bidermanis L. 
Published: November 2013

Abstract
Differential scanning calorimetry was carried out to determine the heat capacity (Cp) of the high temperature resistant ceramic materials to be used as protective coatings for stainless steel tubes of parabolic trough solar collectors in concentrated solar power (CSP) systems. The Ср(Т) measurements and calculations were performed at continuous scanning in the temperature range 20-800 °С. In the work, calibration curves have been derived for conversion of measuring units from mcV into mW. To achieve a better repeatability of measurements, methods for stabilization of the thermal contact between the sample-containing vessel and the probe have been developed. The Ср(Т) dependence was obtained for different ceramic materials.
On the cardinality of n-Urysohn and n-Hausdorff spaces
Authors: Bonanzinga Maddalena , Cuzzupé Maria , Pansera Bruno 
Published: November 2013

Abstract
Two variations of Arhangelskii’s inequality $$\left| X \right| \leqslant 2^{\chi (X) - L(X)}$$ for Hausdorff X [Arhangel’skii A.V., The power of bicompacta with first axiom of countability, Dokl. Akad. Nauk SSSR, 1969, 187, 967–970 (in Russian)] given in [Stavrova D.N., Separation pseudocharacter and the cardinality of topological spaces, Topology Proc., 2000, 25(Summer), 333–343] are extended to the classes with finite Urysohn number or finite Hausdorff number.
Some weak covering properties and infinite games
Authors: Sakai Masami 
Published: November 2013

Abstract
We show that (I) there is a Lindelöf space which is not weakly Menger, (II) there is a Menger space for which TWO does not have a winning strategy in the game Gfin(O,Do). These affirmatively answer questions posed in Babinkostova, Pansera and Scheepers [Babinkostova L., Pansera B.A., Scheepers M., Weak covering properties and infinite games, Topology Appl., 2012, 159(17), 3644–3657]. The result (I) automatically gives an affirmative answer of Wingers’ problem [Wingers L., Box products and Hurewicz spaces, Topology Appl., 1995, 64(1), 9–21], too. The selection principle S1(Do,Do) is also discussed in view of a special base. We show that every subspace of a hereditarily Lindelöf space with an ortho-base satisfies S1(Do,Do).
Mapping Mobile Learning in Space and Time
Authors: Parsons David , Ahn Jae Lim , Lee Ahreum , Song Kiburm , Yoon Miyoung 
Published: November 2013

AbstractMobile learning has been a topic of research and development for 20 years. Over that time it has encompassed a wide range of concepts, theories, designs, experiments and evaluations. With increasing interest in the subject from researchers and practitioners, a comprehensive, yet accessible, overview of mobile learning that encompasses its many facets and features can provide a useful snapshot of the field. Although there have been many reviews of the mobile learning literature, these have tended to focus mostly on the nature of the work from a research perspective. Further, they have focused on a specific subset of the overall literature. Some review articles have, for example, confined themselves to a particular type of mobile learning, such as mobile language learning (e.g. Viberg & Gronlund, 2012). Others have focused on a specific conference series (e.g. Wingkvist & Ericsson, 2011) or subset of journals (e.g. Pollara &Broussard, 2011). In contrast, we have attempted to provide a more generic overview, and analyzed a large number of articles on mobile learning according to their main themes, concepts and concerns. These articles have come from a representative range of journals, books and conference proceedings. This poster provides a full-landscape view of the field of mobile learning in the form of a mind map. Whilst this approach to visualization is relatively subjective, it is a qualitative approach that allows us to find creative associations between ideas, as opposed to some other approaches that simply present quantitative data (Davies, 2011). It also potentially supports additional services such as certain types of information search (Beel &Gipp, 2010). Through an iterative process of refinement, we have applied the main analysis categories of research, learner, learning, content, design and technology, with a range of subcategories and representative exemplars. In addition, we contextualize the key developments in mobile learning in a timeline, in order to trace its evolution as a field of research.
Gene Associated With Retinoid‐Interferon‐Induced Mortality 19 Attenuates Murine Autoimmune Arthritis by Regulation of Th17 and Treg Cells
Authors: Moon Young‐Mee , Lee Jennifer , Lee Seon‐Yeong , Her Yang‐Mi , Ryu Jun‐Geol , Kim Eun‐Kyung , Son Hea‐Jin , Kwok Seung‐Ki , Ju Ji Hyeon , Yang Chul‐Woo , Park Sung‐Hwan , Kim Ho‐Youn , Cho Mi‐La 
Published: November 2013

ObjectiveSTAT‐3 is a key transcriptional factor in the interleukin‐6 (IL‐6)–mediated differentiation of Th17 cells. Because Th17 is believed to be a central player in rheumatoid arthritis (RA), we sought to evaluate whether an endogenous inhibitor of the STAT3 gene, GRIM‐19 (gene associated with retinoid–interferon–induced mortality 19), could attenuate the progression and severity of murine collagen‐induced arthritis (CIA) through suppression of Th17 cells and, reciprocally, could increase expression of Treg cells.MethodsOverexpression of GRIM‐19 was produced either by intravenous/intramuscular administration of a GRIM‐19 overexpression vector in DBA1/J mice or by development of GRIM‐19–transgenic (Tg) mice on a C57BL/6 background. Clinical signs were scored for arthritis severity, and mouse splenocytes, serum, and joint tissue were obtained for immunostaining and histologic analyses.ResultsThe numbers of CD4+IL‐17+ cells and CD4+pSTAT3+ cells were decreased, while the numbers of CD4+CD25+Foxp3+ cells and CD4+pSTAT5+ cells were increased, in both GRIM‐19 vector–transfected and GRIM‐19–Tg mice. Administration of the GRIM‐19 overexpression vector into mice with CIA markedly suppressed the clinical and histologic signs of arthritis in the affected joints. Similarly, when CIA was induced in GRIM‐19–Tg mice, the arthritis phenotype was markedly attenuated and the expression of inflammatory cytokines (IL‐1β, IL‐6, tumor necrosis factor α, and IL‐17) in the arthritic joints was also significantly reduced. Moreover, bone marrow–derived monocyte/macrophages obtained from GRIM‐19–Tg mice showed attenuated RANKL–induced osteoclastogenesis in vitro.ConclusionGRIM‐19 improved the clinical and histologic features of CIA and also inhibited osteoclast formation. These findings suggest that GRIM‐19 may be a novel treatment agent for RA.
Distinct Phenotype Clusters in Childhood Inflammatory Brain Diseases: Implications for Diagnostic Evaluation
Authors: Cellucci Tania , Tyrrell Pascal N. , Twilt Marinka , Sheikh Shehla , Benseler Susanne M. 
Published: November 2013

ObjectiveTo identify distinct clusters of children with inflammatory brain diseases based on clinical, laboratory, and imaging features at presentation, to assess which features contribute strongly to the development of clusters, and to compare additional features between the identified clusters.MethodsA single‐center cohort study was performed with children who had been diagnosed as having an inflammatory brain disease between June 1, 1989 and December 31, 2010. Demographic, clinical, laboratory, neuroimaging, and histologic data at diagnosis were collected. K‐means cluster analysis was performed to identify clusters of patients based on their presenting features. Associations between the clusters and patient variables, such as diagnoses, were determined.ResultsA total of 147 children (50% female; median age 8.8 years) were identified: 105 with primary central nervous system (CNS) vasculitis, 11 with secondary CNS vasculitis, 8 with neuronal antibody syndromes, 6 with postinfectious syndromes, and 17 with other inflammatory brain diseases. Three distinct clusters were identified. Paresis and speech deficits were the most common presenting features in cluster 1. Children in cluster 2 were likely to present with behavior changes, cognitive dysfunction, and seizures, while those in cluster 3 experienced ataxia, vision abnormalities, and seizures. Lesions seen on T2/fluid‐attenuated inversion recovery sequences of magnetic resonance imaging were common in all clusters, but unilateral ischemic lesions were more prominent in cluster 1. The clusters were associated with specific diagnoses and diagnostic test results.ConclusionChildren with inflammatory brain diseases presented with distinct phenotypical patterns that are associated with specific diagnoses. This information may inform the development of a diagnostic classification of childhood inflammatory brain diseases and suggest that specific pathways of diagnostic evaluation are warranted.
Evidence for Interaction Between Markers in GABA(A) Receptor Subunit Genes in an Argentinean Autism Spectrum Disorder Population
Authors: Sesarini Carla V. , Costa Lucas , Naymark Muriel , Grañana Nora , Cajal Andrea R. , García Coto Miguel , Pallia Roberto C. , Argibay Pablo F. 
Published: November 2013

Autism spectrum disorders (ASD) can be conceptualized as a genetic dysfunction that disrupts development and function of brain circuits mediating social cognition and language. At least some forms of ASD may be associated with high level of excitation in neural circuits, and gamma‐aminobutyric acid (GABA) has been implicated in its etiology.Single‐nucleotide polymorphisms (SNP) located within the GABA receptor (GABAR) subunit genes GABRA1, GABRG2, GABRB3, and GABRD were screened. A hundred and thirty‐six Argentinean ASD patients and 150 controls were studied, and the contribution of the SNPs in the etiology of ASD was evaluated independently and/or through gene–gene interaction using multifactor dimensionality reduction (MDR) method.From the 18 SNP studied, 11 were not present in our Argentinean population (patients and controls) and 1 SNP had minor allele frequency < 0.1%. For the remaining six SNPs, none provided statistical significant association with ASD when considering allelic or genotypic frequencies. Non‐significant association with ASD was found for the haplotype analysis. MDR identified evidence for synergy between markers in GABRB3 (chromosome 15) and GABRD (chromosome 1), suggesting potential gene–gene interaction across chromosomes associated with increased risk for autism (testing balanced accuracy: 0.6081 and cross‐validation consistency: 10/10, P < 0.001).Considering our Argentinean ASD sample, it can be inferred that GABRB3 would be involved in the etiology of autism through interaction with GABRD. These results support the hypothesis that GABAR subunit genes are involved in autism, most likely via complex gene–gene interactions. Autism Res 2014, 7: 162–166. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.
Lipid evaluation of farmed and wild meagre (Argyrosomus regius)
Authors: Sinanoglou Vassilia J. , Proestos Charalampos , Lantzouraki Dimitra Z. , Calokerinos Antony C. , Miniadis‐Meimaroglou Sofia 
Published: November 2013

Proximate, lipid, and fatty acid composition of farmed and wild meagre (Argyrosomus regius) muscle, head, skin, and liver, were comparatively studied. Distinct differences were evident in the lipid and fatty acid composition among different tissues of farmed and wild meagre. Total lipid content of the farmed fish parts was significantly higher than that of the wild fish. Neutral lipids, mainly triglycerides, predominated in muscle, head, and skin for both fish. The fact that muscle fat was found significantly lower in triglycerides (TG) concentration than head and skin indicates that muscle consumption after head and skin removal may contribute to a healthy diet. Wild fish muscle, head, and skin fat was found to have significant contribution to the phosphatidylcholine daily intake in the human diet. A. regius liver was also found to be an excellent source of glycerophospholipids. Fatty acid patterns of muscle, head and skin of farmed fish were found to be affected by the feed. MUFA/saturated fatty acid (SFA), PUFA/SFA, and DHA/eicosapentaenoic acid (EPA) ratios were found significantly higher in muscle, head, and skin TL of wild fish compared to the farmed one. Farmed fish muscle could provide similar amount of EPA + DHA and significantly higher amount of ω‐3 PUFA compared to wild fish muscle.Practical applications: Argyrosomus regius is considered a promising fish species for aquaculture due to its tasty meat and great market acceptance in the Mediterranean countries. Hence it is important to determine its lipid and fatty acid content of both farmed and wild fish edible parts (muscle, head, and skin) for nutritional purposes. Remaining parts (such as liver) could still be interesting to analyze for possible use in other food or nutraceutical applications. Here we compare the distribution pattern of lipids and fatty acids of muscles, heads, skin, and liver in wild and farmed A. regius, fed a commercial diet. Furthermore, the present study is a novel comparison between cultured and wild fish species A. regius in terms of their proximate and fatty acid composition.
Development of a Benzimidazole‐Derived Bidentate P,N‐Ligand for Enantioselective Iridium‐Catalyzed Hydrogenations
Authors: Weemers Jarno J. M. , Sypaseuth Fanni D. , Bäuerlein Patrick S. , van der Graaff William N. P. , Filot Ivo A. W. , Lutz Martin , Müller Christian 
Published: November 2013

AbstractThe development of a novel benzimidazole‐derived bidentate P,N‐ligand and its application in Ir‐catalyzed hydrogenation is described. The ligand backbone was obtained through a one‐pot tandem hydroformylation–cyclization sequence and the enantiomers of the generated alcohol were separated by chiral HPLC. By comparing the experimentally obtained CD spectra of the enantiomers with the simulated spectra generated from time‐dependent DFT calculations, the absolute configuration could be obtained. The chiral alcohols could further be isolated on a larger scale after transesterification by using Candida Antarctica lipase B (Novozym 435) and could subsequently be converted into the corresponding chiral P,N‐ligand by reaction with ClPPh2. The coordination properties of the racemic P,N‐ligand were investigated and the molecular structure of the RhI complex [(P,N)Rh(CO)Cl] was determined by X‐ray crystal structure analysis. The corresponding chiral cationic IrI complex was used as catalyst for the enantioselective hydrogenation of prochiral N‐phenyl‐(1‐phenylethylidene)amine and trans‐α‐methylstilbene. For the N‐aryl‐substituted imine, enantiomeric excesses of only 10 % were obtained, whereas the unfunctionalized olefin could be hydrogenated with enantiomeric excesses of up to 90 %. Interestingly, the modular synthetic access to the P,N‐hybrid system described here allows facile modification of the ligand structure, which should extend the scope of such novel P,N‐ligands for asymmetric catalytic conversions to a large extent in the future.
A comparison of wetness indices for the prediction of observed connected saturated areas under contrasting conditions
Authors: Ali Geneviève , Birkel Christian , Tetzlaff Doerthe , Soulsby Chris , McDonnell Jeffrey J. , Tarolli Paolo 
Published: November 2013

ABSTRACTFor lack of other widely available spatial information, topography is often used to predict water fluxes and water quality in mesoscale watersheds. Such data have however proven to be misleading in many environments where large and flat valley bottoms and/or highly conducive soil covers determine water storage and water transport mechanisms. Also, the focus is generally on the prediction of saturation areas regardless of whether they are connected to the catchment hydrographic network or rather present in isolated topographic depressions. Here soil information was coupled with terrain data towards the targeted prediction of connected saturated areas. The focus was on the 30 km2 Girnock catchment (Cairngorm Mountains, northeast Scotland) and its 3 km2 sub‐catchment, Bruntland Burn in which seven field surveys were done to capture actual maps of connected saturated areas in both dry and humid conditions. The 1 km2 resolution UK Hydrology of Soil Types (HOST) classification was used to extract relevant, spatially variable, soil parameters. Results show that connected saturated areas were fairly well predicted by wetness indices but only in wet conditions when they covered more than 30% of the whole catchment area. Geomorphic indices including information on terrain shape, steepness, aspect, soil texture and soil depth showed potential but generally performed poorly. Indices based on soil and topographic data did not have more predictive power than those based on topographic information only: this was attributed to the coarse resolution of the HOST classification. Nevertheless, analyses provided interesting insights into the scale‐dependent water storage and transport mechanisms in both study catchments. Copyright © 2013 John Wiley & Sons, Ltd.
Fluorescence quenching and time‐resolved fluorescence studies on Momordica Charantia (Bitter Gourd) seed lectin
Authors: Padma P. , Komath Sneha Sudha , Swamy Musti J. 
Published: November 2013

AbstractChemical modification studies implicated tryptophan (Trp) residues in the sugar binding activity of Momordica charantia lectin (MCL) [Mazumdar, T., Gaur, N. & Surolia, A. (1981) Eur. J. Biochem. 113, 463–470]. In the present study, the accessibility and environment of Trp residues in MCL were investigated by intrinsic fluorescence quenching and time‐resolved fluorescence. The emission λmm of native MCL in the absence as well as in the presence of 0.1 M lactose was around 335nm, which shifted to 365nm in the presence of 8 M urea, suggesting that the Trp residues which are predominantly buried in the hydrophobic core of the native lectin get exposed to the aqueous environment upon denaturation. At a quencher concentration of 0.5 M, the extent of quenching observed for the native MCL with acrylamide, I and Cs+ was 46%, 17% and 12%, respectively. In the presence of 0.1 M lactose this quenching was smaller, suggesting that the sugar ligand provides a partial protection to the Trp residues. In time‐resolved fluorescence measurements, the decay curves could be fitted well to a biexponential function with the estimated life times 0.92 ns and 4.64 ns for the native protein and 1.15 ns and 5.1 ns in the presence of 0.1 M lactose. All these results are consistent with the involvement of Trp residues in the sugar‐binding activity of MCL.
The G Quotient: Why Gay Executives Are Excelling as Leaders … and What Every Manager Needs to Know
Authors: Stein Irene F. 
Published: November 2013

AbstractBy Kirk SnyderSan Francisco, CA: Jossey‐Bass, 2006. 240 pp. ISBN 978‐1‐118‐43898‐5. $24.95Reviewed by Irene F. Stein, PhD
MRI analysis of cerebellar and vestibular developmental phenotypes in Gbx2 conditional knockout mice
Authors: Szulc Kamila U. , Nieman Brian J. , Houston Edward J. , Bartelle Benjamin B. , Lerch Jason P. , Joyner Alexandra L. , Turnbull Daniel H. 
Published: November 2013

PurposeOur aim in this study was to apply three‐dimensional MRI methods to analyze early postnatal morphological phenotypes in a Gbx2 conditional knockout (Gbx2‐CKO) mouse that has variable midline deletions in the central cerebellum, reminiscent of many human cerebellar hypoplasia syndromes.MethodsIn vivo three‐dimensional manganese‐enhanced MRI at 100‐µm isotropic resolution was used to visualize mouse brains between postnatal days 3 and 11, when cerebellum morphology undergoes dramatic changes. Deformation‐based morphometry and volumetric analysis of manganese‐enhanced MRI images were used to, respectively, detect and quantify morphological phenotypes in Gbx2‐CKO mice. Ex vivo micro‐MRI was performed after perfusion‐fixation with supplemented gadolinium for higher resolution (50‐µm) analysis.ResultsIn vivo manganese‐enhanced MRI and deformation‐based morphometry correctly identified known cerebellar defects in Gbx2‐CKO mice, and novel phenotypes were discovered in the deep cerebellar nuclei and the vestibulo‐cerebellum, both validated using histology. Ex vivo micro‐MRI revealed subtle phenotypes in both the vestibulo‐cerebellum and the vestibulo‐cochlear organ, providing an interesting example of complementary phenotypes in a sensory organ and its associated brain region.ConclusionThese results show the potential of three‐dimensional MRI for detecting and analyzing developmental defects in mouse models of neurodevelopmental diseases. Magn Reson Med 70:1707–1717, 2013. © 2013 Wiley Periodicals, Inc.