bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mindfulness group therapy in primary care patients with depression, anxiety and stress and adjustment disorders: Randomised controlled trial
Authors: Sundquist Jan , Lilja Åsa , Palmér Karolina , Memon Ashfaque A. , Wang Xiao , Johansson Leena Maria , Sundquist Kristina 
Published: November 2014

BackgroundIndividual-based cognitive–behavioural therapy (CBT) is in short supply and expensive.AimsThe aim of this randomised controlled trial (RCT) was to compare mindfulness-based group therapy with treatment as usual (primarily individual-based CBT) in primary care patients with depressive, anxiety or stress and adjustment disorders.MethodThis 8-week RCT (ClinicalTrials.gov ID: NCT01476371) was conducted during spring 2012 at 16 general practices in Southern Sweden. Eligible patients (aged 20–64 years) scored $10 on the Patient Health Questionnaire-9, $7 on the Hospital Anxiety and Depression Scale or 13–34 on the Montgomery–åsberg Depression Rating Scale (self-rated version). The power calculations were based on non-inferiority. In total, 215 patients were randomised. Ordinal mixed models were used for the analysis.ResultsFor all scales and in both groups, the scores decreased significantly. There were no significant differences between the mindfulness and control groups.ConclusionsMindfulness-based group therapy was non-inferior to treatment as usual for patients with depressive, anxiety or stress and adjustment disorders.
ADrosophilaXPD model links cell cycle coordination with neuro-development and suggests links to cancer
Authors: Stettler Karin , Li Xiaoming , Sandrock Björn , Braga-Lagache Sophie , Heller Manfred , Dümbgen Lutz , Suter Beat 
Published: November 2014

AbstractXPD functions in transcription, DNA repair and in cell cycle control. Mutations in human XPD (also known as ERCC2) mainly cause three clinical phenotypes: xeroderma pigmentosum (XP), Cockayne syndrome (XP/CS) and trichothiodystrophy (TTD), and only XP patients have a high predisposition to developing cancer. Hence, we developed a fly model to obtain novel insights into the defects caused by individual hypomorphic alleles identified in human XP-D patients. This model revealed that the mutations that displayed the greatest in vivo UV sensitivity in Drosophila did not correlate with those that led to tumor formation in humans. Immunoprecipitations followed by targeted quantitative MS/MS analysis showed how different xpd mutations affected the formation or stability of different transcription factor IIH (TFIIH) subcomplexes. The XP mutants most clearly linked to high cancer risk, Xpd R683W and R601L, showed a reduced interaction with the core TFIIH and also an abnormal interaction with the Cdk-activating kinase (CAK) complex. Interestingly, these two XP alleles additionally displayed high levels of chromatin loss and free centrosomes during the rapid nuclear division phase of the Drosophila embryo. Finally, the xpd mutations showing defects in the coordination of cell cycle timing during the Drosophila embryonic divisions correlated with those human mutations that cause the neurodevelopmental abnormalities and developmental growth defects observed in XP/CS and TTD patients.
Application of X-ray Absorption Fine Structure (XAFS) Spectroscopy to Speciation of Lead (Pb) Contaminants in Plastics
Authors: Das Anirban , Takahashi Yoshio , Tanaki Asuka 
Published: November 2014

Abstract
A study using X-ray absorption fine structure (XAFS) spectroscopy in conjunction with chemical analyses was undertaken to determine the form of lead (Pb) compound(s) used as additives in plastic bags. Comparison of Pb LIII-edge X-ray absorption near-edge structure (XANES) in samples with those of the standards, and XANES simulation studies revealed that spectra of samples were almost identical to that of PbCrO4, and ca. 80% of Pb was present in the form of PbCrO4. These findings were supported by the facts that Cr-XANES spectra of samples resembled that of PbCrO4, and Cr/Pb molar ratios in samples calculated from simulation of XANES agreed reasonably well with those of the chemical data. Results of k3-weighted extended X-ray absorption fine structure (EXAFS) spectra of three of the samples showed that they resembled that of the PbCrO4.
New Reactive Liquid-crystalline Poly(aminourethane)s and Their Metal-complexed Family
Authors: Ujiie Seiji , Shimada Genichiro , Nata Masanori 
Published: November 2014

Abstract
New liquid-crystalline poly(aminourethane)s (LCPU(T)) were synthesized by the polyaddition of a mesogenic diol and tolylene-2,4-diisocyanate. The mesogenic diol, containing an azobenzene group, formed a monotropic nematic phase in the narrow temperature region. LCPU(T) clearly exhibited a nematic phase on the heating and cooling processes. The fiber and film of LCPU(T) bended through trans–cis isomerization upon UV irradiation at room temperature. LCPU(T) formed a liquid-crystalline polymer–metal complex exhibiting a smectic A phase.
Rhombohedral Hydroxyapatite with Mesoporous Architecture for pH-Responsive Drug Delivery
Authors: Wang Sha , Guo Zhiguang 
Published: November 2014

Abstract
Mesoporous hydroxyapatite (HAp) rhombs were successfully synthesized by transforming CaCO3 into HAp via an ion-exchange reaction without any surfactants. The obtained HAp rhombs with mesoporous architecture exhibited high drug-loading capability and superior sustained release properties, and the drug release rate increased apparently with the decrease of the pH value of the solution medium, which make it a promising carrier for pH-responsive drug-delivery system.
A Fine Tuning of LCST-type Phase Transition of Poly(ionic liquid)s in Water
Authors: Deguchi Yuki , Kohno Yuki , Ohno Hiroyuki 
Published: November 2014

Abstract
This work reports a study of highly temperature-sensitive lower critical solution temperature phase behavior of fully-ionized polyelectrolytes derived from ionic liquids (PILs). We show that important results are obtained by designing a unique preparation process carried out by blending two PILs with different hydrophobicity in aqueous media without copolymerization or precise control of their molecular weight distribution.
Inovação Aberta: como criar e lucrar com a tecnologia
Authors: De Pinto Míriam Magdala 
Published: November 2014

A obra constitui uma contribuição relevante à área de gestão da inovação ao propor que ela deixe de apoiar-se exclusivamente na ideia de que a inovação para ter sucesso precisa ser desenvolvida totalmente dentro das organizações, ou seja, um modelo de inovação fechada, e expanda-se para incluir outro modelo no qual o sucesso da inovação depende do uso pelas organizações de ideias internas e externas e de caminhos diversificados até o mercado, ou seja, um modelo de inovação aberta.
Species diversity and distribution of mangroves in Andaman and Nicobar Islands, India
Authors: Goutham-Bharathi M.P. , Roy S. Dam , Krishnan P. , Kaliyamoorthy M. , Immanuel Titus 
Published: November 2014

Abstract
Despite extensive studies on mangrove ecosystems of Andaman and Nicobar Islands since the 1870s, knowledge of exact species composition is far from complete, and there is a lack of comprehensive locality data. The present study was designed to review the existing literature and to provide an updated checklist of the true mangrove species of the Islands. Preliminary surveys were carried out in seven regions (four from the Andaman group and three from the Nicobar group), and the specific survey sites for detailed study (n=51) were selected based on representativeness, importance, and accessibility. During 2009–2013, all the selected sites were visited, and mangrove species occurrence was recorded. At present, 25 true mangrove species distributed among 10 families and 14 genera were identified vis-à-vis 17 to 36 species reported in earlier studies. The discernible changes in species numbers from earlier studies could mainly be attributed to our exclusion of associated littoral vegetation and of species unlikely to be present among the true mangroves of the Islands. Given their limited geographical area, the low similarity index values between the Andaman and Nicobar Island groups (≤0.4) indicate a need for periodical surveys, as mangrove biodiversity is usually homogenous in regions where there are no impassable dispersal barriers. Further, regular updating of information on the extent and status of mangroves in the Islands is imperative not only to improve our understanding of phytogeography but also for better management and conservation.
The new species Neosiphonia thailandica sp. nov. (Rhodomelaceae, Rhodophyta) from the Gulf of Thailand
Authors: Muangmai Narongrit , Yamagishi Yukimasa , Maneekat Sinchai , Kaewsuralikhit Chatcharee 
Published: November 2014

Abstract
We describe a new epiphytic red alga Neosiphonia thailandica sp. nov. based on a sample collected from Sri Rasha Harbor in the eastern upper Gulf of Thailand. This species grows epiphytically on Gracilaria fisheri, and it is distinguished from other members of the genus by a combination of morphological features: large and slender thalli with narrow axes (up to 15 cm height and 0.5 mm wide), ecortication, well-developed erect habit, few trichoblasts, and abundant adventitious endogenous branchlets occurring in various positions on the thalli. The morphological distinction of N. thailandica is supported by molecular phylogenetic analyses using partial rbcL sequences. Neosiphonia thailandica is positioned within a major clade of the genus Neosiphonia and clustered with Neosiphonia sphaerocarpa and Polysiphonia forfex.
First report of Laurencia chondrioides (Ceramiales, Rhodophyta) and its potential to be an invasive in the eastern Mediterranean Sea
Authors: Hoffman Razy , Sternberg Marcelo , Serio Donatella 
Published: November 2014

Abstract
The Mediterranean coast of Israel is well known as a hotspot of invasive marine species, mostly from the Indian and Pacific oceans. Here, we report the first occurrence of the red seaweed Laurencia chondrioides in the eastern Mediterranean Sea. Large quantities of this species were observed in the algal drift on the sandy shores as well as on rocky surfaces of the upper and middle infralittoral zone. This highly abundant invasive species, present along the northern shore of Israel, represents a serious threat to the local marine flora. Some aspects of its ecology and invasive behavior in this region are also discussed.
Pharmacogenetics of drug-metabolizing enzymes in US Hispanics
Authors: Claudio-Campos Karla , Duconge Jorge , Cadilla Carmen L. , Ruaño Gualberto 
Published: November 2014

AbstractAlthough the Hispanic population is continuously growing in the United States, they are underrepresented in pharmacogenetic studies. This review addresses the need for compiling available pharmacogenetic data in US Hispanics, discussing the prevalence of clinically relevant polymorphisms in pharmacogenes encoding for drug-metabolizing enzymes.CYP3A5*3 (0.245–0.867) showed the largest frequency in a US Hispanic population. A higher prevalence ofCYP2C9*3,CYP2C19*4, andUGT2B7IVS1+985 A>G was observed in US Hispanic vs. non-Hispanic populations. We found interethnic and intraethnic variability in frequencies of genetic polymorphisms for metabolizing enzymes, which highlights the need to define the ancestries of participants in pharmacogenetic studies. New approaches should be integrated in experimental designs to gain knowledge about the clinical relevance of the unique combination of genetic variants occurring in this admixed population. Ethnic subgroups in the US Hispanic population may harbor variants that might be part of multiple causative loci or in linkage-disequilibrium with functional variants. Pharmacogenetic studies in Hispanics should not be limited to ascertain commonly studied polymorphisms that were originally identified in their parental populations. The success of the Personalized Medicine paradigm will depend on recognizing genetic diversity between and within US Hispanics and the uniqueness of their genetic backgrounds.
Microstructural Evolution of TLP Bonded Ti3Al-Nb Alloy Joints
Authors: Gu X.Y. , Duan Z.Z. , Gu X.P. , Sun D.Q. 
Published: November 2014

AbstractIn the present study microstructural evolution in transient liquid phase (TLP) bonded Ti3Al-Nb alloy joints using a pure copper as interlayer was investigated. TLP bonded Ti3Al-Nb alloy joints composed of intermetallic compound layers were produced. Microstructural evolution of joints depended on both bonding time and bonding temperature. With increasing bonding time and bonding temperature, the joint width increased and amount of compounds in the joint decreased. The joint microstructure at 1173 K × 1 min mainly consisted of Ti (solid solution) + Ti2Cu + TiCu + Ti3Cu4 + Ti2Cu3 + TiCu4 + Cu (solid solution) phase and it changed to Ti (solid solution) + Ti2Cu + TiCu at 1223 K × 60 min. Compounds formed on cooling from the bonding temperature by liquid phase were eliminated from the joint at 1223 K × 60 min due to isothermal solidification of liquid phase. The increase of the width of joint is attributed to the composition difference between the isothermal solidification production and its adjacent base material.
Simple groups of automorphisms of trees determined by their actions on finite subtrees
Authors: Banks Christopher , Elder Murray , Willis George A. 
Published: November 2014

Abstract
We introduce the notion of the k-closure of a group of automorphisms of a locally finite tree, and give several examples of the construction. We show that the k-closure satisfies a new property of automorphism groups of trees that generalises Tits' Property P. We prove that, apart from some degenerate cases, any non-discrete group acting on a tree with this property contains an abstractly simple subgroup.
Infinitely-ended hyperbolic groups with homeomorphic Gromov boundaries
Authors: Martin Alexandre , Świątkowski Jacek 
Published: November 2014

Abstract
We show that the Gromov boundary of the free product of two infinite hyperbolic groups is uniquely determined up to homeomorphism by the homeomorphism types of the boundaries of its factors. We generalize this result to graphs of hyperbolic groups over finite subgroups. Finally, we give a necessary and sufficient condition for the Gromov boundaries of any two hyperbolic groups to be homeomorphic (in terms of the topology of the boundaries of factors in terminal splittings over finite subgroups).
Mutation analysis and prenatal diagnosis in a Chinese family with succinic semialdehyde dehydrogenase and a systematic review of the literature of reported ALDH5A1 mutations
Authors: Liu Ning , Kong Xiang-dong , Kan Quan-cheng , Shi Hui-rong , Wu Qing-hua , Zhuo Zhi-hong , Bai Qiao-ling , Jiang Miao 
Published: November 2014

Abstract

Aims: Succinic semialdehyde dehydrogenase (SSADH) deficiency is a neurometabolic disease in which the degradation of γ-aminobutyric acid (GABA) is impaired. The purpose of this study was to report two novel ALDH5A1 mutations responsible for SSADH deficiency in a Chinese family and the prenatal diagnosis of an at-risk fetus with DNA sequencing.

Results: Genetic analysis of ALDH5A1, in a child with SSADH deficiency, parents, and 10 weeks’ gestation at-risk fetus and 100 healthy unrelated volunteers, was performed. The coding sequence and the intron/exon junctions of ALDH5A1 were analyzed by bidirectional DNA sequencing. The proband was identified to have a compound heterozygous mutations with c.496T>C (p.W166R) and c.589G>A (p.V197M). Each of his parents carried a deleterious mutation. DNA sequencing of chorionic villus revealed the fetus was a carrier, but not affected, and this was confirmed after birth by genetic analysis of umbilical cord blood and urine organic acid analysis. A study in 2003 described 35 mutations of ALDH5A1 in 54 unrelated families, and the current study and systematic literature review identified nine additional novel mutations in eight unrelated families bringing the total number of unique mutations of ALDH5A1 resulting in SSADH deficiency to 44, and the 44 mutations occur from exon 1 to exon 10. No mutational hotspots or prevalent mutations were observed, and all mutations appeared vital for the function of SSADH.

Conclusions: Two novel ALDH5A1 mutations likely responsible for SSADH deficiency were identified, and DNA sequencing provided an accurate diagnosis for an at-risk fetus whose sibling had SSADH deficiency.
From Unity to Wholeness
Authors: Gabriel John 
Published: November 2014

AbstractEveryday experience presents us with a world of ordinary objects, but philosophers struggle to devise a useful principle of composition that even comes close to generating just those composites we perceive the world to contain. This paper presents such a principle as a first step toward defending “object dispositionalism” as a theory of material objects. According to object dispositionalism, a plurality composes a whole just when it has the disposition to cause us to perceive a unity in the region it occupies and because it possesses features that in combination realize that disposition. Sections “Object dispositionalism” and “Object dispositionalism’s color counterpart” introduce object dispositionalism and argue it satisfies plausible desiderata for a theory of material objects extant views do not. Relying on cognitive psychologists’ research on object perception, sections “The disposition to what?” through “The general mechanism” explicate the manifestation and basis of the causal power object dispositionalists propose is present wherever composition occurs. Sections “Why object perception researchers are realists” and “When we disagree” describe the perceivers with and conditions in which that causal power manifests and argues object-perception variation doesn’t undermine object dispositionalism’s status as a realist view.
Fetal hydrocephalus
Authors: Kitova Tanya , Kitov Borislav , Milkov Denis , Cheikh Nahed Ben , Gaigi Soumeya 
Published: November 2014

Abstract
The aim of this study was to draw the attention of specialists faced with fetal hydrocephalus in the postnatal period to the possibilities of prenatal diagnosis and further monitoring by studying isolated and syndrome cases in fetuses. One hundred and nine fetuses from a total of 2238 autopsies were the subject of observation in this study. In 64 (58.7%) of the studied fetuses, isolated hydrocephalus was found, while the other 45 cases were associated with the following malformations: Arnold-Chiari type II, Dandy-Walker, stenosis of the aqueductus sylvii, agenesis of corpus callosum (partial and total) and numerical chromosomal aberrations such as trisomy 13, 15 and 18. In cases of isolated hydrocephalus and a stable condition of the fetus, it is possible to wait until the term, or to induce labor without danger to the child, followed by a shunting intervention.
Ermittlung der Kapillartransportkoeffizienten mineralischer Baustoffe aus dem w-Wert / Estimating the capillary transport coefficients of mineral building materials from the water absorption coefficient
Authors: Krus M. , Holm A. , Schmidt Th. 
Published: November 2014

Abstract
Computer calculations are of increasing importance for the assessment of moisture balance in building components, since modern calculation methods achieve good agreement with measurements. A broader application of these methods is hampered, however, by the laborious measurements needed to determine the capillary transport coefficients essential for the calculations. A new method is therefore presented which allows to estimate the coefficients from wellknown standard material properties (free capillary saturation, practical moisture content and water absorption coefficient). These coefficients are sufficient for estimative assessment of the moisture balance of many materials, as is demonstrated by comparison of suction profiles calculated in this way and measured profiles.
Anwendung der geologischen Gefügekunde zur Charakterisierung natürlicher Werksteine - Fallbeispiel: Kauffunger Marmor / Application of geological fabric analyses for the characterization of natural building stones. - Case study: Kauffung marble
Authors: Siegesmund S. , Vollbrecht A. , Ullemeyer K. , Sobott R. 
Published: November 2014

Abstract
In geology, methods of fabric analyses are largely applied in order to reconstruct the rock-forming processes and define the environments in which they formed. Often, rocks are characterized by polyphase imprints, which occured over a long time span under varying conditions (pressure, temperature, chemical environmentj. In these cases, the final fabrics are usually rather complex. The Kauffung marble is used as an example to demonstrate, how the methods of geological fabric analyses can be applied to the characterization of natural building stones. A correlation with petrophysical analyses reveals that the most important fabric parameters are crystallographic-preferred orientation (texture), the shape-preferred orientation and the microcrack populations, which are usually responsible for a distinct anisotropy. They mainly control the directional dependence of the material properties. These anisotropic properties should be considered during the cutting and later use of natural building stones.
Hydrophobierung des Betons - Ökologische und ökonomische Aspekte / Water Repellent Treatment of Concrete - ecological and economical aspects
Authors: Haag C. , Gerdes A. , Wittmann F .H. 
Published: November 2014

Abstract
The use ofdeicing salts on roads may lead to chloride ion induced corrosion. This deterioration mechanism has become one of the most frequent reasons for repair measures within the planned service-life of concrete structures. One way of reducing the risk of chloride ion induced corrosion is the prevention of the penetration of dissolved chloride into the concrete. By water repellent surface treatment the water and chlorid penetration rate can be substantially slowed down. As the water repellent treatment has a limited service-life and its performance and durability depend on many parameters, no standard performance criteria for the water repellent treatment could be defined yet. This study compares the economical and ecological impact of a water repellent treatment with the impact of repair measures. Results are meant to be used to define standard performance criteria. These criteria must take into consideration not only the performance with respect to the reduction of chloride penetration rate, but also garantee the required durability.The expected life-time of an untreated reinforced concrete element can be estimated by modelling the mechanism of chloride ion induced corrosion. Based on this value the frequency of repair measures within a planned service-life of 100 years can be determined. Comparing the ecological and economical impact of a water repellent treatment with the corresponding impact of repair measures allows us to the formulate performance criteria concerning the durability and the minimum required service-life of a water repellent treatment. The water repellent treatment has to prevent repair measures within the planned service-life of a structural concrete element. Technical criteria concerning the performance of a water repellent treatment within the minimum required service-life can be formulated.
Sanierungskonzeption einer 700 Jahre alten Dorfkirche in Sachsen-Anhalt / Refurbishment concept for a 700 year old church in Sachsen-Anhalt (East-Germany)
Authors: Böhm S. , Thiele R. 
Published: November 2014

Abstract
Currently, there are a great amount of cultural and historical important structures in East Germany, where maintance and refurbishment is necessary. Therefore refurbishment work is more often the business of the local engineer. The refurbishment concept of a small church will be presented. Under consideration of the main aspects as maintance of historical features, statical safety and economical belongings the design documents have been created