bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurophysiological correlates of eye movement desensitization and reprocessing sessions: preliminary evidence for traumatic memories integration
Authors: Farina Benedetto , Imperatori Claudio , Quintiliani Maria I. , Castelli Gattinara Paola , Onofri Antonio , Lepore Marta , Brunetti Riccardo , Losurdo Anna , Testani Elisa , Della Marca Giacomo 
Published: August 2014

SummaryWe have investigated the potential role of eye movement desensitization and reprocessing (EMDR) in enhancing the integration of traumatic memories by measuring EEG coherence, power spectra and autonomic variables before (pre‐EMDR) and after (post‐EMDR) EMDR sessions during the recall of patient's traumatic memory. Thirteen EMDR sessions of six patients with post‐traumatic stress disorder were recorded. EEG analyses were conducted by means of the standardized Low Resolution Electric Tomography (sLORETA) software. Power spectra, EEG coherence and heart rate variability (HRV) were compared between pre‐ and post‐EMDR sessions. After EMDR, we observed a significant increase of alpha power in the left inferior temporal gyrus (T = 3·879; P = 0·041) and an increased EEG coherence in beta band between C3 and T5 electrodes (T = 6·358; P<0·001). Furthermore, a significant increase of HRV in the post‐EMDR sessions was also observed (pre‐EMDR: 6·38 ± 6·83; post‐EMDR: 2·46 ± 2·95; U‐Test= 45, P = 0·043). Finally, the values of lagged coherence were negatively associated with subjective units of disturbance (r(24) = −0·44, P<0·05) and positively associated with parasympathetic activity (r(24)=0·40, P<0·05). Our results suggest that EMDR leads to an integration of dissociated aspects of traumatic memories and, consequently, a decrease of hyperarousal symptoms [Correction made here after initial publication].
Assessing and accounting for the impact of respiratory motion on FDG uptake and viable volume for liver lesions in free‐breathing PET using respiration‐suspended PET images as reference
Authors: Li Guang , Schmidtlein C. Ross , Burger Irene A. , Ridge Carole A. , Solomon Stephen B. , Humm John L. 
Published: August 2014

Purpose:To assess and account for the impact of respiratory motion on the variability of activity and volume determination of liver tumor in positron emission tomography (PET) through a comparison between free‐breathing (FB) and respiration‐suspended (RS) PET images.Methods:As part of a PET/computed tomography (CT) guided percutaneous liver ablation procedure performed on a PET/CT scanner, a patientˈs breathing is suspended on a ventilator, allowing the acquisition of a near‐motionless PET and CT reference images of the liver. In this study, baseline RS and FB PET/CT images of 20 patients undergoing thermal ablation were acquired. The RS PET provides near‐motionless reference in a human study, and thereby allows a quantitative evaluation of the effect of respiratory motion on PET images obtained under FB conditions. Two methods were applied to calculate tumor activity and volume: (1) threshold‐based segmentation (TBS), estimating the total lesion glycolysis (TLG) and the segmented volume and (2) histogram‐based estimation (HBE), yielding the background‐subtracted lesion (BSL) activity and associated volume. The TBS method employs 50% of the maximum standardized uptake value (SUVmax) as the threshold for tumors with SUVmax ≥ 2× SUVliver‐bkg, and tumor activity above this threshold yields TLG50%. The HBE method determines local PET background based on a Gaussian fit of the low SUV peak in a SUV‐volume histogram, which is generated within a user‐defined and optimized volume of interest containing both local background and lesion uptakes. Voxels with PET intensity above the fitted background were considered to have originated from the tumor and used to calculate the BSL activity and its associated lesion volume.Results:Respiratory motion caused SUVmax to decrease from RS to FB by −15% ± 11% (p = 0.01). Using TBS method, there was also a decrease in SUVmean (−18% ± 9%, p = 0.01), but an increase in TLG50% (18% ± 36%) and in the segmented volume (47% ± 52%, p = 0.01) from RS to FB PET images. The background uptake in normal liver was stable, 1% ± 9%. In contrast, using the HBE method, the differences in both BSL activity and BSL volume from RS to FB were −8% ± 10% (p = 0.005) and 0% ± 16% (p = 0.94), respectively.Conclusions:This is the first time that almost motion‐free PET images of the human liver were acquired and compared to free‐breathing PET. The BSL methodˈs results are more consistent, for the calculation of both tumor activity and volume in RS and FB PET images, than those using conventional TBS. This suggests that the BSL method might be less sensitive to motion blurring and provides an improved estimation of tumor activity and volume in the presence of respiratory motion.
Walking Workstation Use Reduces Ambulatory Blood Pressure in Adults with Prehypertension
Authors: Zeigler Zachary S. , Swan Pamela D. , Bhammar Dharini M. , Gaesser Glenn A. 
Published: August 2014

Background:The acute effect of low-intensity walking on blood pressure (BP) is unclear.Purpose:To determine if the acute use of a walking workstation reduces ambulatory blood pressure (ABP) in prehypertensive men and women.Methods:Ten prehypertensive adults participated in a randomized, cross-over study that included a control workday and a walking workstation workday. ABP was measured for 7 hour during the workday and for 6 hour after work.Results:Both systolic BP (SBP) (134 ± 14 vs. 137 ± 16 mmHg; P = .027) and diastolic BP (DBP) (79 ± 10 vs. 82 ± 12 mmHg; P = .001) were lower on the walking workstation day. Postwork hours (4:00 PM–10:00 PM), SBP (129 ± 13 vs. 133 ± 14 mmHg; P = .008), and DBP (74 ± 11 vs. 78 ± 13 mmHg; P = .001) were also lower on the walking workstation day. DBP load was significantly lower during the walking workstation day, with only 14% of the readings above 90 mmHg compared with 22% of the control day readings (P = .037).Conclusion:Accumulation of very-light-intensity physical activity (~2 METs) over the course of a single work day using a walking workstation may reduce BP burden in prehypertensive individuals.
Complete Genome Sequence of Porcine Epidemic Diarrhea Virus in Vietnam
Authors: Vui Dam Thi , Tung Nguyen , Inui Ken , Slater Steven , Nilubol Dachrit 
Published: August 2014

ABSTRACT
Porcine epidemic diarrhea virus (PEDV) has emerged in Vietnam since 2009. Herein, full-length genome sequences are reported for three PEDV isolates from pigs displaying severe diarrhea from farms located in northern and southern provinces of Vietnam. The results provide more understanding of the molecular characteristics of PEDV in Vietnam.
Complete Genome Sequence of an Alkane Degrader,
Alcanivorax
sp. Strain NBRC 101098
Authors: Miura Takamasa , Tsuchikane Keiko , Numata Mitsuru , Hashimoto Maiko , Hosoyama Akira , Ohji Shoko , Yamazoe Atsushi , Fujita Nobuyuki 
Published: August 2014

ABSTRACT

Alcanivorax
sp. strain NBRC 101098 was isolated from seawater in Japan. Strain NBRC 101098 is able to degrade various types of
n
-alkanes. Here, we report the complete genome of strain NBRC 101098.
High-Quality Draft Genomes of Two Vibrio parahaemolyticus Strains Aid in Understanding Acute Hepatopancreatic Necrosis Disease of Cultured Shrimps in Mexico
Authors: Gomez-Jimenez Silvia , Noriega-Orozco Lorena , Sotelo-Mundo Rogerio R. , Cantu-Robles Vito A. , Cobian-Guemes Ana G. , Cota-Verdugo Rosario G. , Gamez-Alejo Luis A. , del Pozo-Yauner Luis , Guevara-Hernandez Eduardo , Garcia-Orozco Karina D. , Lopez-Zavala Alonso A. , Ochoa-Leyva Adrián 
Published: August 2014

ABSTRACT

The high-quality draft genomes of two
Vibrio parahaemolyticus
strains, one that causes the acute hepatopancreatic necrosis disease (AHPND) in cultured shrimps (FIM-S1708
+
), and another that does not (FIM-S1392
−
) are reported. A chromosome-scale assembly for the FIM-S1392
−
genome is reported here. The analysis of the two genomes gives some clues regarding the genomic differences between the strains.
Magnetite-bubble aggregates at mixing interfaces in andesite magma bodies
Authors: Edmonds M. , Brett A. , Herd R. A. , Humphreys M. C. S. , Woods A. 
Published: August 2014

Abstract
Magnetite is a particularly favourable site for heterogeneous bubble nucleation in magma and yet only very rarely is evidence for this preserved due to the myriad of processes that act to overprint such an association. The possibility of bubble-magnetite aggregates in magmas carries with it interesting implications for the fluid mechanics of magma bodies and for the magma mixing process responsible for the formation of andesites. We use image analysis and statistical methods to illustrate a spatial association between magnetite and bubbles in mafic enclaves. There is a large range in magnetite contents in the enclaves (up to 7.5%) which is related to the porosity of the enclaves, indicating a mechanism of enrichment of the mafic magma in magnetite. In the andesite there is no spatial association between bubbles and magnetite and the magnetite content of the andesite is small. We suggest a mechanism for enclave formation whereby in vapour-saturated magma, bubbles nucleate on magnetite. Upon intrusion into the base of an andesite magma body, these bubble-magnetite aggregates rise and ‘sweep up’ other magnetites, resulting in the accumulation of aggregates at the magma interface. Instabilities lead to the flotation of enclaves, characterized by enrichment in magnetite and bubbles.
Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy
Authors: Huang Jing , Xiao Lin , Gong Xiaoting , Shao Wenwei , Yin Yanhui , Liao Qinyuan , Meng Yang , Zhang Yingmei , Ma Dalong , Qiu Xiaoyan 
Published: August 2014

AbstractCCDC134 is a poorly characterized secreted protein that may act as an immune cytokine. Here, we show that CCDC134 is differentially expressed on resting and activated immune cells and that it promotes CD8+ T-cell activation, proliferation, and cytotoxicity by augmenting expression of the T-cell effector molecules IFNγ, TNFα, granzyme B, and perforin. CCDC134 facilitated infiltration of CD8+ T cells with enhanced cytolytic activity into tumors, demonstrating strong antitumor effects in a CD8+ T-cell–dependent manner. Mechanistically, in CD8+ T cells, exposure to CCDC134 promoted cell proliferation through the JAK3–STAT5 pathway, a classic feature of many cytokines of the common γ-chain (γc) cytokine receptor family. Overall, our results provide evidence that CCDC134 may serve as a member of the γc cytokine family and illustrate its potent antitumor effects by augmenting CD8+ T-cell–mediated immunity. Cancer Res; 74(20); 5734–45. ©2014 AACR.
Preparation and antitumor effect of a toxin-linked conjugate targeting vascular endothelial growth factor receptor and urokinase plasminogen activator
Authors: Xiang Ying , Li Qiying , Huang Dehong , Tang Xianjun , Wang Li , Shi Yang , Zhang Wenjun , Yang Tao , Xiao Chunyan , Wang Jianghong 
Published: August 2014

The aberrant signaling activation of vascular endothelial growth factor receptor (VEGFR) and urokinase plasminogen activator (uPA) is a common characteristic of many tumors, including lung cancer. Accordingly, VEGFR and uPA have emerged as attractive targets for tumor. KDR (Flk-1/VEGFR-2), a member of the VEGFR family, has been recognized as an important target for antiangiogenesis in tumor. In this study, a recombinant immunotoxin was produced to specifically target KDR-expressing tumor vascular endothelial cells and uPA-expressing tumor cells and mediate antitumor angiogenesis and antitumor effect. Based on its potent inhibitory effect on protein synthesis, Luffin-beta (Lβ) ribosome-inactivating protein was selected as part of a recombinant fusion protein, a single-chain variable fragment against KDR (KDRscFv)-uPA cleavage site (uPAcs)-Lβ-KDEL (named as KPLK). The KDRscFv-uPAcs-Lβ-KDEL (KPLK) contained a single-chain variable fragment (scFv) against KDR, uPAcs, Lβ, and the retention signal for endoplasmic reticulum proteins KDEL (Lys-Asp-Glu-Leu). The KPLK-expressing vector was expressed in Escherichia coli, and the KPLK protein was isolated with nickel affinity chromatography and gel filtration chromatography. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis test demonstrated KPLK was effectively expressed. Result of in vitro cell viability assay on non-small cell lung cancer (NSCLC) H460 cell line (uPA-positive cell) revealed that KPLK significantly inhibited cell proliferation, induced apoptosis, and accumulated cells in S and G2/M phases, but the normal cell line (human submandibular gland cell) was unaffected. These effects were enhanced when uPA was added to digest KPLK to release Lβ. For in vivo assay of KPLK, subcutaneous xenograft tumor model of nude mice were established with H460 cells. Growth of solid tumors was significantly inhibited in animals treated with KPLK up to 21 days, tumor weights were decreased, and the expression of angiogenesis marker CD31 was downregulated; meanwhile, the apoptosis-related protein casspase-3 was upregulated. These results suggested that the recombinant KPLK may have therapeutic applications on tumors, especially uPA-overexpressing ones.
Crustal deformations in Kii peninsula associated with the SE off the Kii peninsula earthquake sequence of September 5, 2004 derived from dense GPS observations
Authors: Hashimoto Manabu , Onoue Kensuke , Ohya Fumio , Hoso Yoshinobu , Segawa Kohei , Sato Kazutoshi , Fujita Yasuyoshi 
Published: August 2014

AbstractWe present crustal deformations in southern Kii peninsula, southwest Japan, before and after the SE off the Kii peninsula earthquake sequence of September 5, 2004, which were obtained from repeated surveys of dense GPS network. Disaster Prevention Research Institute (hereafter DPRI), Kyoto University made a reoccupation of their dense GPS network network that was occupied in February-March, 2004, right after the event to obtain crustal deformations associated with this event. Since we do not have the data just before the event, we apply an inversion of displacements of GEONET sites during the period from February-March to August, and interpolate displacements at DPRI’s sites using the inverted fault model. Southward movements of about 2 cm are obtained in the middle of Kii peninsula, while displacements are rotated to southwest on the west side. These characteristics of horizontal displacement field cannot be explained only by a pure thrust faulting, but additional sources such as right-lateral faulting on a NW-SE trending fault are required.
A dense GPS observation immediately after the 2004 mid-Niigata prefecture earthquake
Authors: Takahashi Hiroaki , Matsushima Takeshi , Kato Teruyuki , Takeuchi Akira , Yamaguchi Teruhiro , Kohno Yuhki , Katagi Takeshi , Fukuda Jun’ichi , Hatamoto Kazuya , Doke Ryousuke , Matsu’ura Yuki , Kasahara Minoru 
Published: August 2014

AbstractTo investigate the postseismic crustal deformation associated with the 2004 mid-Niigata prefecture earthquake (M6.8), we newly started GPS observation to fill a gap of the nationwide continuous GPS network. Our GPS sites were mainly distributed in the focal region without permanent GPS site, and succeeded in obtaining the postseismic deformation. Coseismic displacements of two aftershocks were clearly detected because of immediate observation. Estimated fault parameters of the aftershock (M5.9) on November 8 occurring just beneath our GPS network indicated that geodetic data could be explained by either east- or west-dipping fault model inferred from detailed aftershock data. Moreover, clear postseismic deformation, which could be characterized by a logarithmic decay function, was observed. This signal probably suggests possible aseismic slip. Our results indicated that dense GPS observation could give important and interesting data to clarify the properties of shallow inland middle-size earthquakes.
Landform and local site effects on the colonies worst-hit by the 2004 mid-Niigata prefecture, Japan, earthquake
Authors: Yoshimi Masayuki , Komatsubara Taku , Miyachi Yoshinori , Kimura Katsumi , Sekiguchi Haruko , Saeki Masayuki , Kunimatsu Sunao , Yoshida Kunikazu , Ozaki Masanori , Nakazawa Tsutomu , Nakashima Rei , Saomoto Hidetaka 
Published: August 2014

Abstract
Landform and damage classification surveys have been conducted on six colonies worst-hit by the 2004 mid-Niigata prefecture earthquake. The landform was classified using aerial photographs taken by the US Air Force in 1947. Damage degree of each structure has been classified into four classes including foundation damage class, and location of each structure has been mapped with damage class. Around 1,000 houses and stores have been classified and mapped. In five of six colonies, buildings on the fans composed of colluvial deposits have been more likely suffered severe damage than those on terraces or dissected valleys. In the other colony located on a flood plain, no clear difference in degree of damage among landforms has been observed.
Utility of petrophysical and geophysical data to constrain the subsurface structure of the Kitakami plutons, northeast Japan
Authors: Okuma Shigeo , Kanaya Hiroshi 
Published: August 2014

Abstract
The Geological Survey of Japan (GSJ), AIST has been systematically measuring physical properties of basement rocks in Japan for more than 30 years and has started to construct a petrophysical database called PB-Rock 21 (Petrophysical Database of Basement rocks in Japan for the 21st Century, http://www.aist.go.jp/RIODB/PB-Rock21/). The petrophysical data has been integrated with aeromagnetic data to determine the subsurface structure of the Himekami and Sobanokami plutons, members of the Kitakami plutonic belt, northeast Japan. For the Himekami pluton, the result of apparent magnetization intensity mapping clearly shows zonation within sub-plutons as well as regional rock type differences between the North (felsic) and South (felsic and mafic complex) sub-plutons. The bottom depths of the pluton were estimated by a successive 3-D magnetic modeling to be 1.7 km (North sub-pluton) and 1.5 km below sea level (South sub-pluton), respectively. Magnetic modeling of the Sobanokami pluton, which is partly exposed at the eastern edge of the Ishinomaki Plain, implies that the main part of the pluton extends to the northwest below the surface. Its western edge is cut by the Ishinomaki-wan fault, believed to be the upward extension of the fault plane of the 2003 northern Miyagi earthquake as defined by seismic observations and reflection seismic surveys conducted after the earthquake. Integrated magnetic and gravity modeling suggests that the Kakeyama Formation, a Neogene conglomerate deposited in a half-graben along the Ishinomaki-wan fault during Miocene rifting, contains more granitic fragments toward the south than to the north in the Ishinomaki Plain.
High resolution 3-D velocity structure in the source region of the 2000 Western Tottori Earthquake in southwestern Honshu, Japan using very dense aftershock observations
Authors: Shibutani Takuo , Katao Hiroshi ,   Group for the dense aftershock observations of the 2000 Western Tottori Earthquake
Published: August 2014

Abstract
We carried out high density aftershock observations a week after the 2000 Western Tottori Earthquake for 40 days. We deployed 72 seismic stations in and around the aftershock area. The average spacing of the stations in the aftershock area was 4–5 km. We determined accurate hypocenters and focal mechanisms for ∼1,000 aftershocks and obtained a high resolution 3-D velocity structure in the source region. High P and S wave velocity anomalies (> 4%) near the southeasternmost aftershock area at 2 km depth correlated with Jurassic to Late Cretaceous plutonic and high pressure metamorphic rocks. The depth distribution of the P and S wave velocities along the mainshock fault showed that high velocity anomalies were located at the shallow southeastern edge and the deeper central part of the aftershock area. The ratio between P and S wave velocities in the high velocity anomalies was a little higher (∼1.75) than the average value (∼1.70) in the upper crust. These results indicate that the high velocity anomalies could correspond to the plutonic or metamorphic rocks. The distributions of the high velocity anomalies and large slips of the mainshock were complementary. These suggest that the high velocity anomalies could be stronger than the surrounding materials and might behave as barriers to the mainshock rupture.
Surface deformations associated with the October 2004 Mid-Niigata earthquake: Description and discussion
Authors: Yoong Kim Haeng , Okada Atsumasa 
Published: August 2014

AbstractThe Mid-Niigata earthquakes (mainshock: JMA M6.8, the largest aftershock: JMA M6.4) occurred on 23 October 2004 in the Shinano River fold and thrust zone, western margin of Northeast Japan. Two major Quaternary reverse fault systems, fault related to Higashiyama—Tamguiyama fold in western side and Muikamachi fault in eastern side, had already been mapped in aftershock area from the geological structure and tectonic morphostructure. These active fault and fold strike almost north-northeast—south-southwest. We investigated destructions of man-made structures and surface deformation using the releveling data by Geography Survey Institute. In turn, we examined about the origin of observed surface destructions from the compare with aftershock distribution. Our leveling and G.S.I leveling results indicate the deformation concordant with the Higashiyama-Tamugiyama fold and the offset along the a part of the northern half of Muikamachi fault. The vertical displacements are estimated to be ca. 70 cm and less than 20 cm, respectively. The surface destructions were identified almost only along the Suwatoge flexure (correlated to the eastern limb of the Higashiyama-Tamugiyama fold), Tagawa anticline, Obiro fault and Muikamachi fault. The shortening amounts were estimated to be ca. 16 cm at the Suwatoge flexure, less than 2 cm at the Tagawa anticline and ca. 8 cm at the Muikamachi fault from the compressional destruction of man-made structure. The maximum vertical displacement and shortening was appeared at the bottom of Suwatoge flexure. The Suwatoge flexure is located onto the shallower extension of the row of aftershocks which was correlated to main shock earthquake. The Muikamachi fault is located near the shallower extension of the source fault of the largest aftershock. The stress regime inferred from the character of the observed surface destructions is concordant with the trend of geological structure and focal mechanism solutions. The small compressional destructions of man-made structures are byproducts created by buried faulting and folding. Thus, the Higashiyama-Tamugiyama folding structure grew in association with the buried faulting in the 2004 earthquake.