bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review and meta‐analysis to predict mortality in heart failure with preserved ejection fraction: Development and validation of the HF‐DANAS score
Authors: Wang Chuanhe , Guan Lin , Han Su , Tong Fei , Li Ying , Li Zhichao , Sun Hao , Sun Zhijun 
Published: August 2024

AbstractAimsThe morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) continue to increase with the accelerating global aging process. During the past decade, the pathophysiology, diagnostic methods, and prognostic prediction of HFpEF have been revolutionized, resulting in new and effective management strategies. Dynamic prognostic assessment facilitates systematic clinical management of patients, and the aim of this study was to investigate the risk factors for mortality in patients with HFpEF and to develop a risk prediction assessment model.Methods and reultsData for the derivation cohort were obtained from three databases, PubMed, Embase, and Cochrane. The validation cohort was obtained from the Chinese Heart Failure Center database. The β‐coefficient was calculated based on the risk ratio (RR) and 95% confidence intervals (CI) corresponding to each risk factor to construct a mortality risk assessment model. A total of 30 studies were included in the meta‐analysis: 22 prospective cohort studies and 8 retrospective cohort studies, including 34 196 HFpEF patients. Seven predictors of all‐cause mortality in HFpEF patients were derived. Considering the need for feasibility in clinical practice, we performed subgroup and sensitivity analyses and determined the following cutoff values: age > 75 years (RR: 2.07, 95% CI: 1.83–2.35; P < 0.001), male sex (RR: 1.36, 95% CI: 1.17–1.59; P < 0.001), DM (RR: 1.23, 95% CI: 1.11–1.36; P < 0.001), anaemia (RR: 1.53, 95% CI: 1.41–1.67; P < 0.001), albumin concentration < 3.2 g/dL (RR: 1.29, 95% CI: 1.14–1.47; P < 0.001), AF (RR: 1.27, 95% CI: 1.12–1.43; P < 0.001), and NYHA class III/IV (RR: 1.63, 95% CI: 1.43–1.87; P < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for this model was 71.3% (95% CI: 0.696–0.736), with an optimal cut‐off value of 10.75. The sensitivity and specificity were 0.778 and 0.566, respectively. According to this risk score, we divided patients into three risk classes (low, moderate, and high risk), the numbers of patients who died by the end of the 1‐year follow‐up were 23 (1.87%), 82 (5.62%), and 382 (15.52%) in these three groups, and the 5‐year mortality rates were 9.82%, 20.68%, and 43.28%, respectively.ConclusionsThis study developed an HF‐DANAS scoring system for the HFpEF mortality risk containing seven predictors, providing clinicians with a simple assessment tool that can help improve clinical management.
Heart failure with improved versus persistently reduced left ventricular ejection fraction: A comparison of the BIOSTAT‐CHF (European) study with the ASIAN‐HF registry
Authors: Cao Thong Huy , Tay Wan Ting , Jones Donald J.L. , Cleland John G.F. , Tromp Jasper , Emmens Johanna Elisabeth , Teng Tiew‐Hwa Katherine , Chandramouli Chanchal , Slingsby Oliver Charles , Anker Stefan D. , Dickstein Kenneth , Filippatos Gerasimos , Lang Chim C. , Metra Marco , Ponikowski Piotr , Samani Nilesh J. , Van Veldhuisen Dirk J. , Zannad Faiez , Anand Inder S. , Lam Carolyn S.P. , Voors Adriaan A. , Ng Leong L. 
Published: August 2024

AimsWe investigated the prevalence, clinical characteristics, and prognosis of patients with heart failure (HF) with improved ejection fraction (HFimpEF).Methods and resultsWe used data from BIOSTAT‐CHF including patients with a left ventricular ejection fraction (LVEF) ≤40% at baseline who had LVEF re‐assessed at 9 months. HFimpEF was defined as a LVEF >40% and a LVEF ≥10% increase from baseline at 9 months. We validated findings in the ASIAN‐HF registry. The primary outcome was a composite of time to HF rehospitalization or all‐cause mortality. In BIOSTAT‐CHF, about 20% of patients developed HFimpEF, that was associated with a lower primary event rate of all‐cause mortality (hazard ratio [HR] 0.52, 95% confidence interval [CI] 0.28–0.97, p = 0.040) and the composite endpoint (HR 0.46, 95% CI 0.30–0.70, p < 0.001) compared with patients who remained in persistent HF with reduced ejection fraction (HFrEF). The findings were similar in the ASIAN‐HF (HR 0.40, 95% CI 0.18–0.89, p = 0.024, and HR 0.29, 95% CI 0.17–0.48, p < 0.001). Five independently common predictors for HFimpEF in both BIOSTAT‐CHF and ASIAN‐HF were female sex, absence of ischaemic heart disease, higher LVEF, smaller left ventricular end‐diastolic and end‐systolic diameter at baseline. A predictive model combining only five predictors (absence of ischaemic heart disease and left bundle branch block, smaller left ventricular end‐systolic and left atrial diameter, and higher platelet count) for HFimpEF in the BIOSTAT‐CHF achieved an area under the curve of 0.772 and 0.688 in the ASIAN‐HF (due to missing left atrial diameter and platelet count).ConclusionsApproximately 20–30% of patients with HFrEF improved to HFimpEF within 1 year with better clinical outcomes. In addition, the predictive model with clinical predictors could more accurately predict HFimpEF in patients with HFrEF.
Electrochemical Construction of C−F Bonds: Recent Advances and Future Perspectives
Authors: Li Boao , Xu Muwu , Feng Pengju , Xu Shihai 
Published: August 2024

AbstractIdeal pathways to synthesize fluorinated compounds were pursued for over 100 years, due to wide application of organofluorides in materials, agrochemicals and pharmaceuticals. In this regard, electro‐organic synthesis, evolved as a sustainable and scalable approach in various synthetic protocols, stands out as a promising strategy. As a result, many novel and attracting applications of introduction of fluorine items into organic compounds by direct and redox‐mediated electrochemical methods has been reported, especially in recent five years. In this review, we are aim to highlight the reaction scopes, reaction mechanism, the fundamental aspects and the fluorine source variation in electrochemcial fluoriation transformation.
Palladium Supported on Silk Fibroin as Efficient Catalyst for Sonogashira Coupling and Sonogashira‐Cacchi Type Annulation
Authors: Albano Gianluigi , Rizzo Giorgio , Salvati Fabio , Pitzalis Emanuela , Ricciardelli Carola , Aronica Laura A. , Farinola Gianluca M. 
Published: August 2024

AbstractA palladium catalyst supported on silk fibroin (Pd/SF) has been tested in the Sonogashira coupling reactions of a wide range of aryl iodides and terminal alkynes. The best catalytic performance was obtained at 90 °C using only 0.25 mol % metal loading under copper‐free conditions, in the presence of a H2O/EtOH (3 : 2 v/v) solvent mixture and triethylamine as the base, affording the coupling products in good yields. The Pd/SF‐based protocol was then successfully extended to the synthesis of benzofurans through Sonogashira‐Cacchi type annulation of 2‐iodophenol with terminal alkynes. Preliminary investigations on the recyclability and the heterogeneous behaviour of the catalyst were performed: hot filtration test and leaching test evidenced the presence of a small amount of soluble active palladium species into the reaction mixture. Nevertheless, Pd/SF could be reused in recharging test and it can be recycled in four consecutive runs with no significant deactivation.
Three‐Component Synthesis of Fluorescent 1,4‐Benzothiazin‐2‐ones Through Thiol‐Free Iodine‐Catalyzed Cyclization
Authors: Rajkumar Deepan Babu , Gnanaoli Karthiyayini , Krishnamoorthy Kirubashini , Maheswari C. Uma 
Published: August 2024

AbstractA convergent synthesis of 2H‐benzo[b][1,4]thiazin‐2‐one was achieved via iodine‐catalyzed three‐component reaction. This strategy involves the formation of two new C−S bonds and a C−N bond from the readily available precursors ‐ aryl methyl ketones, p‐anisidine, and elemental sulfur to generate the desired heterocycle in moderate to good yields. As the synthesized benzothiazine‐2‐ones are fluorescent under UV light, photophysical properties like solid‐state emission, solvatochromism, Aggregation Induced Emission (AIE), and the relative quantum yields of the compounds were measured which proves them to be a potential candidate for the development of optoelectronic devices.
Seminal root angle is associated with root system architecture in durum wheat
Authors: Kang Yichen , Rambla Charlotte , Haeften Shanice V. , Fu Brendan , Akinlade Oluwaseun , Potgieter Andries B. , Borrell Andrew K. , Mace Emma , Jordan David R. , Alahmad Samir , Hickey Lee T. 
Published: August 2024

AbstractOptimal root system architecture (RSA) is critical for efficient resource capture in soils, hence being an interest in crop breeding. Seminal root angle (SRA) at the seedling stage in durum wheat has been suggested to be a good indicator of RSA. However, research on correlating such laboratory‐based seedling root phenotyping to RSA at later phases of plant growth is limited, resulting in the importance of root trait variation seen in seedlings often being overstated. To explore the role of SRA in modifying RSA at later phases of plant growth, we assessed 11 genotypes contrasting in SRA (wide and narrow), grown in a rhizobox designed for phenotyping root systems of plants during late‐tillering. Aboveground traits and root dry mass in different soil depths and across the entire soil volume were measured manually, while root architectural traits were extracted using image analysis and summarised by multiple factor analysis to describe RSA. When comparing the wide and narrow genotypes, no differences were detected for aboveground traits and total root dry mass. However, differences were observed in the allocation of root dry mass at different depths. The wide and narrow genotypes showed distinct RSAs, particularly in the upper soil (0–30 cm). The wide genotypes exhibited a ‘spread‐out’ root system with dense and thin roots, whereas the narrow genotypes had a compact root system with fewer but thicker roots. Our study demonstrated a clear difference in RSA between the wide and narrow genotypes, highlighting the association between SRA on the direction and distribution of root growth in plants at later growth stages.
Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes
Authors: Bouras Ahmed , Fabre Aurélie , Zattara Hélène , Handallou Sandrine , Desseigne Françoise , Kientz Caroline , Prieur Fabienne , Peysselon Magalie , Legrand Clémentine , Calavas Laura , Saurin Jean‐Christophe , Wang Qing 
Published: August 2024

ABSTRACTA substantial number of hereditary colorectal cancer (CRC) and colonic polyposis cannot be explained by alteration in confirmed predisposition genes, such as mismatch repair (MMR) genes, APC and MUTYH. Recently, a certain number of potential predisposition genes have been suggested, involving each a small number of cases reported so far. Here, we describe the detection of rare variants in the NTLH1, AXIN2, RNF43, BUB1, and TP53 genes in nine unrelated patients who were suspected for inherited CRC and/or colonic polyposis. Seven of them were classified as pathogenic or likely pathogenic variants (PV/LPV). Clinical manifestations of carriers were largely consistent with reported cases with, nevertheless, distinct characteristics. PV/LPV in these uncommon gene can be responsible for up to 2.7% of inherited CRC or colonic polyposis syndromes. Our findings provide supporting evidence for the role of these genes in cancer predisposition, and contribute to the determination of related cancer spectrum and cancer risk for carriers, allowing for the establishment of appropriate screening strategy and genetic counseling in affected families.
Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study
Authors: Ebrahimi Ardalan , Gupta Ruta , McDowell Lachlan , Magarey Matthew J. R. , Smith Paul N. , Schulte Klaus‐Martin , Perriman Diana M. , Veness Michael , Porceddu Sandro , Low Tsu‐Hui Hubert , Fowler Allan , Clark Jonathan R. 
Published: August 2024

AbstractBackgroundWe aimed to identify predictors of distant metastatic recurrence (DMR) in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) with nodal metastases treated with curative intent.MethodsPredictors of DMR were identified using Cox regression in a multicenter study of 1151 patients.ResultsThe 5‐year risk of DMR was 9.6%. On multivariate analysis, immunosuppression (HR 2.93; 95% CI: 1.70–5.05; p < 0.001), nodal size >6 cm [versus ≤3 cm (HR 2.77; 95% CI: 1.09–7.03; p = 0.032)], ≥5 nodal metastases [versus 1–2 (HR 2.79; 95% CI: 1.63–4.78; p < 0.001)], and bilateral disease (HR 3.11; 95% CI: 1.40–6.90; p = 0.005) predicted DMR. A DMR risk score was developed that stratified risk from 6.6% (no risk factors) to 100% (≥3 risk factors) (p < 0.001).ConclusionsThe risk of DMR in nodal metastatic HNcSCC increases with immunosuppression, nodal size >6 cm, ≥5 nodal metastases, and bilateral disease. A simple DMR risk score estimated prior to treatment may be clinically useful.
The efficacy and safety of using prophylactic abdominal drainage after laparoscopic cholecystectomy: A randomized control trial
Authors: Arnaout Ahmad Y. , Kadoura Lama , Masri Ruqaya , Nerabani Yaman , Atli Abd Alazeez , Arnaout Khaled , Arnaout Ibrahim , Bsata Adel , Kayali Hasan , Mahli Nehad , Al‐Haj Ahmad , Ayoub Kusay , Niazi Ammar , Ghazal Ahmad ,   Aleppo University Hospital Team
Published: August 2024

AbstractBackgroundThe use of prophylactic drainage after laparoscopic cholecystectomy has been a routine practice for many years. However, the debate surrounding using it stems from conflicting evidence regarding its potential benefits and risks.MethodsPatients who underwent laparoscopic cholecystectomy from February 1, 2022, to November 30, 2022, at Aleppo University Hospital were enrolled according to our previously registered protocol (NCT05267860).ResultsThis study included 232 patients (117 in the drainage group [DG], and 115 in the non‐drainage group [NDG]). There was no statistical difference in the patients' main characteristics, comorbidities, and laboratory findings. The duration of the surgical operation in NDG (mean = 44.92, SD = 1.85) was shorter than in DG (mean 55.14, SD = 2.14), with (p = 0.039) statistically significant, which indicates that the use of the drainage led to a prolongation of the surgical operation. The total number of complicated cases reached 22 (9.48%) cases (DG = 9 vs. NDG = 13, p = 0.348) as follows: bleeding (n = 1) (DG = 1 vs. NDG = 0; p = 0.320), bile leak with no established bile duct injury (n = 1) (DG = 1 vs. NDG = 0; p = 0.320), wound infection (n = 12) (DG = 4 vs. NDG = 8; p = 0.443), urinary tract infection (n = 3) (DG = 0 vs. NDG = 3; p = 0.079), prolonged shoulder pain (n = 2) (DG = 0 vs. NDG = 2; p = 0.152), and acute pancreatitis (n = 1) (DG = 1 vs. NDG = 0; p = 0.144).ConclusionBased on the results of our study, the use of prophylactic drainage was safe, but ineffective, as it did not improve the outcomes statistically significantly or worsen them, which is consistent with previous studies highlighting the need for personalized patient care in this setting.
Do school Water, Sanitation, and Hygiene facilities affect students' health status, attendance, and educational achievements? A qualitative study in Nepal
Authors: Sharma Mohan Kumar , Adhikari Ramesh , Khanal Shanti Prasad , Acharya Devaraj , van Teijlingen Edwin 
Published: August 2024

AbstractBackground and AimsAccess to safe and sufficient drinking Water, Sanitation, and good Hygiene (WASH) facilities in schools play a crucial role in preventing students from numerous Neglected Tropical Diseases, improving the learning environment in schools, and creating resilient communities living in a healthy environment. This study aims to explore the impact of combining WASH facilities on students' health status, school attendance, and educational achievements.MethodsFour schools, two with improved and two without improved WASH facilities, were selected purposively from Dhanusha and Chitwan districts of Nepal. A total of 24 participants, 16 students, and eight teachers were also purposively selected based on the Theory of Data Saturation. The participants were interviewed face‐to‐face using study guidelines; Key Informants Interview for teachers and In‐depth Interview for students. The data were audio recorded and analyzed thematically using Dedoose 9.0.17 qualitative data management and analysis software.ResultsSchool WASH facilities have a significant impact on students' health and well‐being. Poor school‐WASH facilities hindered students' school attendance, particularly for menstruating girls. School without separate toilets for girls, including menstruation hygiene facilities, lack of water and soap, sanitary pad, and secure toilet's door often have higher rates of absenteeism among girls. Poor teacher and students' relationships, students' low interest in education, household chores, and participation in social customs also contribute to students' absence from school and low educational performance. It is important to note that inadequate WASH facilities affect not only students, but also teachers in the same school.ConclusionThe lack of safe and sufficient drinking water, unimproved sanitation, and poor hygiene facilities were seen by students and teachers as reducing their health and well‐being, school attendance, and academic performance. Thus, schools need prioritize and promote the provision of improved WASH facilities for the betterment of students' health, attendance, and educational proficiency.
Trends and inequalities in neonatal mortality rate in Bangladesh: Evidence from cross‐sectional surveys
Authors: Dey Rakhi , Kundu Satyajit , Ajayi Kobi V. , Kabir Humayun , Banna Md. Hasan Al 
Published: August 2024

AbstractBackground and AimsGiven the significance of addressing neonatal mortality in pursuing the 2030 Sustainable Development Goal on child health, research focus on this area is crucial. Despite the persistent high rates of neonatal mortality rate (NMR) in Bangladesh, there remains a notable lack of robust evidence addressing inequalities in NMR in the country. Therefore, this study aims to fill the knowledge gap by comprehensively investigating inequalities in NMR in Bangladesh.MethodsThe Bangladesh Demographic and Health Survey (BDHS) data from 2000 to 2017 were analyzed. The equity stratifiers used to measure the inequalities were wealth status, mother's education, place of residence, and subnational region. Difference (D) and population attributable fraction (PAF) were absolute measures, whereas population attributable risk (PAR) and ratio (R) were relative measures of inequality. Statistical significance was considered by estimating 95% confidence intervals (CIs) for each estimate.ResultsA declining trend in NMR was found in Bangladesh, from 50.2 in 2000 to 31.9 deaths per 1000 live births in 2017. This study detected significant wealth‐driven (PAF: −20.6, 95% CI: −24.9, −16.3; PAR: −6.6, 95% CI: −7.9, −5.2), education‐related (PAF: −11.6, 95% CI: −13.4, −9.7; PAR: −3.7, 95% CI: −4.3, −3.1), and regional (PAF: −20.6, 95% CI: −27.0, −14.3; PAR: −6.6, 95% CI: −8.6, −4.6) disparities in NMR in all survey points. We also found a significant urban–rural inequality from 2000 to 2014, except in 2017. Both absolute and relative inequalities in NMR were observed; however, these inequalities decreased over time.ConclusionSignificant variations in NMR across subgroups in Bangladesh highlight the need for comprehensive, and targeted interventions. Empowering women through improved access to economic resources and education may help address disparities in NMR in Bangladesh. Future research and policies should focus on developing strategies to address these disparities and promote equitable health outcomes for all newborns.
Investigating correlates of children's emotional well‐being: Parenting stress and child temperament
Authors: Çelebi Şevval , Acar Ibrahim H. 
Published: August 2024

AbstractChildren's emotional well‐being may emerge as a result of the dynamic interplay between individual factors, such as temperament and environmental factors, such as parenting stress. The current study aimed to investigate the contributions of child temperament and parenting stress to children's emotional well‐being. This study also examined the moderating role of parenting stress on the association between child temperament and children's emotional well‐being. Participants were mothers of 219 Turkish preschool children (110 girls) aged 36 months to 76 months (M = 56.95 months, SD = 11.73 months). Mothers reported on children's emotional well‐being (emotion regulation, emotion dysregulation, child aggression and child anxiety), temperament (persistence and reactivity) and parenting stress. Persistence was negatively associated with emotion dysregulation and child aggression, while reactivity was negatively associated with emotion regulation and positively associated with emotion dysregulation, aggression and anxiety. Parenting stress was negatively associated with emotion regulation and positively associated with emotion dysregulation, aggression and anxiety. Simple slope analyses revealed that high persistence coupled with low parenting stress was associated with higher emotion regulation, while low persistence paired with high parenting stress was linked to higher child aggression. The findings underline the significance of child temperament and parenting stress for children's emotional well‐being.Highlights

Temperamental persistence is negatively associated with emotion dysregulation and aggression.
Temperamental reactivity is negatively associated with emotion regulation and positively associated with emotion dysregulation, aggression and anxiety.
Parenting stress was negatively associated with emotion regulation and positively associated with emotion dysregulation, aggression and anxiety in children.
Gynecologic health care for LGBTQIA+ people
Authors: Ferreira‐Filho Edson Santos , Lerner Theo , Soares‐Júnior José Maria , Baracat Edmund Chada 
Published: August 2024

AbstractGender relations are a set of socially determined norms and rules that assign values, characteristics, and expectations to individuals based on their biological sex. These aspects also influence the clinician–patient relationship, since it has been for a long time based on cisheteronormativity. However, this attitude alienated the LGBTQIA+ community from health services. Global and specific gynecologic care needs to be offered to the LGBTQIA+ population, which has demands for sexual and reproductive health care. In this narrative review, we bring conceptual aspects, gender identity and expression, sexual history, screening for cancer and other care to the community.