bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple NSAID Intolerance in Chronic Idiopathic Urticaria Is Correlated with Delayed, Pronounced and Prolonged Autoreactivity
Authors: Erbagci Zülal 
Published: July 2014

AbstractAutologous serum skin test (ASST) reactivity is positive in up to 60% of patients with chronic idiopathic urticaria (CIU). About 21 to 30% of patients with CIU have intolerance to acetyl salicylic acid (ASA) and/or other chemically unrelated non‐steroidal anti‐inflammatory drugs (NSAIDs). To investigate the relationship between ASA/NSAID intolerance and ASST reactivity, a case‐control study was performed in 110 patients with CIU and 60 healthy controls. A positive ASST was defined as an erythematous wheal with a diameter of ≥ 5 mm more than the saline‐induced response. Patients were assessed at 10‐minute intervals for a minimum of three hours. ASA/NSAID intolerance was ascertained by a placebo controlled‐provocation test with offending drug (s). Forty‐two patients with CIU (38.2%) had autoreactivity whereas only two of the controls (3.3%) displayed early and weak skin responses (P<.0001). ASA/NSAID intolerance was demonstrated in 30 (27.3%) patients with CIU. The prevalences of autoreactivity were 93.3% (28/30) and 17.5% (14/80) in patients with and without ASA/NSAID intolerance, respectively (P<.001). Thirteen of the 25 ASST‐positive patients (52%) who had single (n: 7) or multiple (n: 6) NSAID intolerance showed early (before or at 30 min) and mild autoreactivity of short duration, whereas 15 of the remaining 17 ASST‐positive patients (88.2%) who all had multiple NSAID intolerance showed delayed (later than 30 min) and prolonged autoreactivity (P<.05). These findings suggest that a common mechanism may be responsible for the pathogeneses of both delayed autoreactivity and multiple NSAID intolerance in CIU. It might be further speculated that delayed, prolonged, and pronounced autoreactivity may be a possible predictor for multiple NSAID sensitivity in CIU.
Monitoring of ELISA for Anti‐BP180 Antibodies: Clinical and Therapeutic Analysis of Steroid‐Treated Patients with Bullous Pemphigoid
Authors: Izumi Tomoko , Ichiki Yoshiro , Esaki Chikako , Kitajima Yasuo 
Published: July 2014

AbstractWe studied the precise correlation between ELISA values for BP180 NC16A and the alternations of disease activity in 5 patients with bullous pemphigoid (BP) during various treatments and tried to answer the question of how we can use ELISA to determine the timing of prednisolone (PSL) tapering. Disease activity in some patients with BP, but not in all, was poorly correlated with ELISA values in short‐term follow‐up. However, all patients showed a good correlation of disease activity with ELISA values as a whole in long‐term follow‐up. Three patients with typical BP showed rapid and good responses to PSL for erosion and blister formation. Their ELISA values gradually decreased to 40% of initial values during PSL therapy after four weeks. Two patients with the vesicular type of BP did not show rapid and good responses to PSL for erosion and blister formation. In the cases with the vesicular type of BP, diaphenylsulfone in addition to PSL dramatically improved the clinical symptoms including erosion and blister formation, even though the ELISA values were as high as those before treatment. Relapses did not occur with the tapering of PSL dosage when the ELISA values decreased to 40% of initial values, although they were still not within the normal range.
High‐Dose Intravenous Immunoglobulins in the Treatment of Toxic Epidermal Necrolysis: An Asian Series
Authors: Tan Audrey W. , Thong Bernard Y. , Yip Leonard W. , Chng Hiok Hee , Ng See Ket 
Published: July 2014

AbstractToxic epidermal necrolysis (TEN) is a severe, immune‐mediated, mucocutaneous reaction resulting in extensive keratinocyte apoptosis. High‐dose human intravenous immunoglobulins (IVIG) have been proposed as an effective treatment for TEN. Retrospective data from 8 patients with TEN and 4 patients with Stevens‐Johnson syndrome‐toxic epidermal necrolysis (SJS‐TEN) overlap treated with high‐dose IVIG were analysed. The total dose of IVIG administered was 2 g/kg body weight, with the exception of 2 patients who received a total dose of 1.5 g/kg body weight. Their mean age was 49.9 ± 18.8 years (range, 19 to 70 years). The mean time from the first sign of skin lesion or mucosal or epidermal detachment to commencement of IVIG was 8.7 ± 5.5 days (range, 3 to 22 days). Of the 11 patients who survived, the mean time to objective response was 3.6 ± 1.9 days (range, 2 to 8 days). The length of stay (LOS) in hospital was 20.4 ± 8.0 days (range, 10 to 37 days). The survival rate was 91.6%. One patient developed permanent mucocutaneous sequelae following TEN. There were no adverse reactions to IVIG. We conclude that high‐dose IVIG may be a safe and effective therapy for Asian patients with TEN.
Mucinous Nevus
Authors: Yokogawa Maki , Kamakura Tomoko , Ishiguro Hiroaki , Ikeda Mitsunori , Kodama Hajime 
Published: July 2014

AbstractA 15‐year‐old boy first noticed multiple firm papules on his right upper chest two years before presenting to our clinic. These papules were densely distributed and showed epidermal nevus‐like linear arrangement at some sites. The number, size, and distribution of these papules remained unchanged for one year of our observation. The papules flattened leaving scars and did not recur within a year after one shaving abrasion using a scalpel. Histopathologically, epidermis of the papule displayed acanthosis with elongated rete ridges. Accumulation of mucin was apparent in the papillary and subpapillary dermis. In mucinous nevus, the origin of cells with nevoid proliferation is obscure. In contrast with common collagenous connective tissue nevus, it is hard to define the localized persistent mucin accumulation as a nevoid manifestation. The present case of mucinous nevus might be caused by significantly stimulated glycosaminoglycan synthesis in a kind of epidermal nevus without extreme hyperkeratosis.
Synchronous Microcystic Adnexal Carcinoma and Gastric Cancer with Review of the Literature
Authors: Ohtsuka Hisashi , Nozawa Ryouta , Kushida Yoshio 
Published: July 2014

AbstractA microcystic adnexal carcinoma (MAC) on the left lateral chest was synchronously accompanied by both an adenocarcinoma and a granular cell tumor of the stomach in a 70‐year‐old Japanese male. The MAC lesion had first appeared approximately 20 years earlier and had slowly increased without symptoms. After a definitive diagnosis was made by an excisional biopsy, a second operation was performed with wider excision, followed by split thickness skin grafting. Meanwhile, a punch biopsy from an erosive lesion, which was performed three days before the second operation, demonstrated gastric cancer. Consequently, a gastrectomy was undertaken 20 days later. The patient had since been followed for 2 years and 3 months without any sign of recurrence nor metastasis. Subsequently, soft lymph nodes in two regions of the left axilla were noticed. Three lymph nodes were excised for diagnostic purposes and found to be reactive hyperplasia without metastasis of skin tumor cells. To our knowledge, in the literature, 11 patients have been reported with MAC associated with double or multiple cancers which developed syn‐ or meta‐chronously; ours is the 12th patient.
Pericostal Tuberculosis Diagnosed by Fine Needle Aspiration Biopsy: Report of a Case with a Review of the Literature
Authors: Abe Hiroyuki , Kumamoto Kensuke , Hoshino Masami , Utsumi Yasufumi , Takenoshita Seiichi , Kaneko Fumio 
Published: July 2014

AbstractWe present an 81‐year‐old woman with pericostal tuberculosis, a rare disease recently, without a past history of pulmonary tuberculosis or tuberculous pleurisy. She developed a subcutaneous nodule on her right chest. She was suspected of skin tuberculosis after the confirmation of acid‐fast bacilli in a fine needle aspiration material of the nodule. A tuberculin skin test was strongly positive. The nodule was resected, and preclusive antituberculosis chemotherapy with rifampicin and isoniazid was started. The histological findings included granulomatous changes, central necrosis and Langhans' giant cells. Mycobacterium tuberculosis was identified from a culture of the specimen. About six months after the operation, no erythema, nodule or abscess was observed. We first suspected that she had mammary carcinoma and therefore observed the nodules on the thorax; it is important to differentiate tuberculosis from neoplasms. We also reviewed 22 cases of pericostal tuberculosis in Japan reported in the 15 years from 1976 to 2002.
Trichophyton Tonsurans Infection Manifesting as Multiple Concentric Annular Erythemas
Authors: Ouchi Takeshi , Nagao Keisuke , Hata Yasuki , Otuka Tomoko , Inazumi Toyoko 
Published: July 2014

AbstractWe report a case of dermatophytosis in a Judo wrestler caused by Trichophyton tonsurans (T. tonsurans) with clinical features that mimicked the concentric rings of tinea imbricata. Tinea imbricata is a unique dermatophytosis caused by Trichophyton concentricum (T. concentricum), observed endemically in subtropical to torrid zones and characterized by impressive concentric rings. We found three similar cases of the dermatophytosis in the literature that were reported as tinea pseudoimbricata or tinea indecisiva. All of these cases were associated with systemic or local immunosuppression, perhaps simulating the mechanism of tinea imbricata, which is known to involve the lack of delayed type hypersensitivity to T. concentricum. These cases imply that iatrogenic immunosuppression may perhaps play an important role in the development of the unique clinical features mimicking tinea imbricata. Furthermore, three of the four cases, including the presented case, were caused by T. tonsurans. It may be necessary to consider T. tonsurans infection when multiple concentric erythemas are encountered.
Mycophenolate Mofetil as an Adjuvant Therapy for Classic and Endemic Pemphigus Foliaceus
Authors: Kawashita Milka Yuri , Tsai Katia , Aoki Valéria , Santi Claudia Giuli , Maruta Celina Wakisaka , Rivitti Evandro 
Published: July 2014

AbstractPemphigus foliaceus is an autoimmune cutaneous disease with subcorneal acantholysis and pathogenic IgG4 autoantibodies directed against desmoglein 1. We present our experience with mycophenolate mofetil (MMF) in the treatment of one case of endemic pemphigus foliaceus (fogo selvagem) and two cases of the classic form. All patients had severe, refractory disease and developed marked adverse effects due to long‐term corticosteroid therapy. MMF proved to be an effective corticosteroid‐sparing agent at doses varying from 35 to 45 mg/kg/d. It was well tolerated, and we found no significant adverse effects from this drug.
Psoriasis Arthropathy and HLA‐B51: Report of 5 Cases
Authors: Yamamoto Toshiyuki , Yokozeki Hiroo , Nishioka Kiyoshi 
Published: July 2014

AbstractPsoriasis arthropathy (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis with psoriasis. Although the precise mechanisms of PsA still remain obscure, several genetic and environmental factors have been suggested to play important roles. HLA‐B51 has been strongly associated with Behçet's disease; however, its association with PsA has not been documented. We describe herein five Japanese patients (4 males and 1 female) with PsA and positive for HLA‐B51. The clinical forms defined by Moll and Wright revealed that the polyarticular pattern was noted in two cases, and oligoarticular, distal, and spondyloarthropathy patterns were noted in one case each. Positive rheumatoid factor was detected in one patient, and antinuclear antibody in two patients. The other HLA subclasses were A2 and A31 in 3 cases, respectively. HLA‐B51 was detected in 5 out of 17 patients with PsA examined in our department; in contrast, HLA‐B51 was not detected in 17 patients with psoriasis vulgaris. Our observations suggest that HLA‐B51 may play a role in the pathogenesis of PsA in the Japanese population.
Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*
Authors: Ungerstedt Urban 
Published: July 2014

AbstractThe ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions. The anatomy of the pathways is outlined in drawings of frontal sections of the brain and the origin and termination of several pathways is determined by studying the anterograde and retrograde degeneration occurring after well localised lesions. It is possible to separate the ascending NA pathways into a dorsal and a ventral bundle of axons. The dorsal bundle innervates the cortex and the hippocampus and the ventral bundle supplies NA nerve terminals to the medulla, the pons, the mesencephalon and the diencephalon. The dorsal bundle is found to originate in the locus coeruleus. Lesions of this nucleus abolish the nerve terminals in all cortical areas and in several other areas of the brain indicating a unique role for the locus coeruleus in influencing the activity of the entire brain. The 5‐HT pathways have a distribution similar to the ventral NA pathyway. The course of the nigro‐striatal and the meso‐limbic DA pathways is presented in detail.
Striatal Dopamine Release after Amphetamine or Nerve Degeneration Revealed by Rotational Behaviour
Authors: Ungerstedt U. 
Published: July 2014

AbstractAmphetamine induced vigorous rotational behaviour in rats where the nigrostriatal dopamine (DA) system was unilaterally degenerated by an intracerebral injection of 6‐hydroxydopamine (6‐OH‐DA). The rotational behaviour was analysed in a specially designed “rotometer” and found highly reproducable. The intensity of the rotation was proportional to the extent of degeneration in the DA system. The amphetamine site of action was in all probability presynaptic as amphetamine caused a rotation in the opposite direction as compared to the DA receptor stimulating drug apomorphine. Tyrosine hydroxylase inhibition abolished the amphetamine effect, while reserpine potentiated the effect. Evidence was also obtained that the amphetamine induced release of DA was dependent upon nerve impulses. The rotational behaviour reflected the degree of DA receptor stimulation, but changes in the noradrenaline (NA) transmission seemed to modulate the behaviour. Decreased NA transmission after dopamine‐β‐hydroxylase inhibition increased the rotational behaviour. The unilateral degeneration of the DA system was studied by the changes in posture and movements that occurred during the degeneration. After inhibition of the monoamine oxidase the rats showed a strong rotation beginning on the 23d and ending on the 33d hour after the operation. The rotational behaviour was probably due to degeneration release of DA and equivalent to the degeneration contraction of the nictitating membrane in the peripheral nervous system Amphetamine greatly potentiated the spontaneous degeneration release during this period.
Past, Present, and Future of Water Data Delivery from the U.S. Geological Survey
Authors: Hirsch Robert M. , Fisher Gary T. 
Published: July 2014

AbstractWe present an overview of national water databases managed by the U.S. Geological Survey, including surface‐water, groundwater, water‐quality, and water‐use data. These are readily accessible to users through web interfaces and data services. Multiple perspectives of data are provided, including search and retrieval of real‐time data and historical data, on‐demand current conditions and alert services, data compilations, spatial representations, analytical products, and availability of data across multiple agencies.
A Vision for Future Observations for Western U.S. Extreme Precipitation and Flooding
Authors: Ralph F.M. , Dettinger M. , White A. , Reynolds D. , Cayan D. , Schneider T. , Cifelli R. , Redmond K. , Anderson M. , Gherke F. , Jones J. , Mahoney K. , Johnson L. , Gutman S. , Chandrasekar V. , Lundquist J. , Molotch N. , Brekke L. , Pulwarty R. , Horel J. , Schick L. , Edman A. , Mote P. , Abatzoglou J. , Pierce R. , Wick G. 
Published: July 2014

AbstractRecent and historical events illustrate the vulnerabilities of the U.S. west to extremes in precipitation that result from a range of meteorological phenomena. This vision provides an approach to mitigating impacts of such weather and water extremes that is tailored to the unique meteorological conditions and user needs of the Western U.S. in the 21st Century. It includes observations for tracking, predicting, and managing the occurrence and impacts of major storms and is informed by a range of user‐requirements, workshops, scientific advances, and technological demonstrations. The vision recommends innovations and enhancements to existing monitoring networks for rain, snow, snowmelt, flood, and their hydrometeorological precursor conditions, including radars to monitor winds aloft and precipitation, soil moisture sensors, stream gages, and SNOTEL enhancements, as well as entirely new observational tools. Key limitations include monitoring the fuel for heavy precipitation, storms over the eastern Pacific, precipitation distributions, and snow and soil moisture conditions. This article presents motivation and context, and describes key components, an implementation strategy, and expected benefits. This document supports a Resolution of the Western States Water Council for addressing extreme events.
Landsat Thermal Infrared Imagery and Western Water Management
Authors: Willardson Anthony G. 
Published: July 2014

AbstractThe Western States Water Council strongly supported the use of thermal infrared sensor (TIRS) data from Landsat 8 (Western States Water Council ). TIRS is increasingly important in monitoring consumptive water uses, particularly agricultural uses. Landsat is the only operational satellite system with a spatial resolution (30m) fine enough to map water use field‐by‐field. TIRS data applications include:
Administering state water rights
Planning for present and future water needs
Implementing interstate compacts, court decrees, and negotiated tribal settlements
Mapping evapotranspiration and consumptive surface and groundwater use
Protecting endangered species and estimating water use by invasive species
Monitoring food supply security
Forecasting commodity market fluctuations
TIRS is essential to quantify beneficial consumptive use, evaluate water rights transfer requests, monitor interstate water compacts, negotiate tribal water right settlements and interstate agreements, and review water right “calls.” The Landsat data archive tracks temporal changes in water uses over decades. A permanent operational land observation program with TIRS is essential.
A Social‐Ecological Framework to Integrate Multiple Objectives for Environmental Flows Management
Authors: Martin David M. , Harrison‐Atlas Dylan , Sutfin Nicholas A. , Poff N. LeRoy 
Published: July 2014

Abstract“Environmental flows” is a research discipline that emphasizes freshwater allocation in rivers to sustain desired ecological conditions and human well‐being. The basis for environmental flow requirements has traditionally relied on hydrological and ecological data. Contemporary methods focus on detailed hydro‐ecological relationships within river ecosystems; however, there is currently no structured approach to systematically incorporate socially relevant data into the environmental flows discipline. To address this limitation we developed a flexible framework that applies a social‐ecological systems approach to account for multiple flow‐related objectives that reflect both biophysical sustainability and societal preferences. First, we conceptualize the freshwater social‐ecological system as a hierarchy of human and environmental domains. Then, we recommend stepwise procedures to assess flow‐related vulnerabilities of important system attributes, address their feedbacks, and translate these assessments to a common classification for comparative analyses that guide holistic flow management decisions.
Social Observation for Sustainability Science about Water
Authors: Braden John B. 
Published: July 2014

AbstractI advance the following argument: (1) Coupled observation of humans and nature at large scale is important to many fundamental questions of sustainability. (2) Current programs observing natural and social systems are inadequate to address fundamental questions of sustainability at coarse scale. (3) Water is an attractive medium around which to design an observation program, and water researchers agree on many characteristics of water‐related data needed to advance sustainability science. (4) A program of coupled observation around water will need to be (a) realistic about attainable scope, (b) design data collection scientifically to be representative at useful scale(s) and of both humans and the hydrosphere, (c) leverage existing data collection programs, (d) explore new ways of protecting privacy while enhancing spatial resolution of data and (e) include data on social institutions as well as individuals.
Reach‐Scale Comparison of Habitat and Mollusk Assemblages for Select Sites in the Clinch River with Regional Context
Authors: Ostby Brett J.K. , Krstolic Jennifer L. , Johnson Gregory C. 
Published: July 2014

AbstractSeveral hypotheses, including habitat degradation and variation in fluvial geomorphology, have been posed to explain extreme spatial and temporal variation in Clinch River mollusk assemblages. We examined associations between mollusk assemblage metrics (richness, abundance, recruitment) and physical habitat (geomorphology, streambed composition, fish habitat, and riparian condition) at 10 sites selected to represent the range of current assemblage condition in the Clinch River. We compared similar geomorphological units among reaches, employing semi‐quantitative and quantitative protocols to characterize mollusk assemblages and a mix of visual assessments and empirical measurements to characterize physical habitat. We found little to no evidence that current assemblage condition was associated with 54 analyzed habitat metrics. When compared to other sites in the Upper Tennessee River Basin (UTRB) that once supported or currently support mollusk assemblages, Clinch River sites were more similar to each other, representing a narrower range of conditions than observed across the larger geographic extent of the UTRB. A post‐hoc analysis suggested stream size and average boundary shear stress at bankfull stage may have historically limited species richness in the UTRB (p < 0.001). Associations between mollusk assemblages and physical habitat in the UTRB and Clinch River currently appear obscured by other factors limiting richness, abundance, and recruitment.