bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular-Genetic Aspects of Breast Cancer
Authors: Krasteva M. , Angelova Sv , Gospodinova Zl 
Published: May 2015

Summary
Breast cancer is the most frequent malignancy among women. Advances in breast cancer knowledge have deciphered the involvement of a number of tumor suppressor genes and proto-oncogenes in disease pathogenesis. These genes are part of the complex biochemical pathways, which enable cell cycle control and maintenance of genome integrity. Their function may be disrupted as a result of alterations in gene sequence or misregulation of gene expression including alterations in DNA methylation pattern. The present review summarizes the main findings on major breast cancer related genes BRCA1/2, p53, ATM, CHEK2, HER2, PIK3CA and their tumorigenic inactivation/activation. The potential clinical importance of these genes with respect to patients’ prognosis and therapy are also discussed. The possible implication of other putative breast cancer related genes is also outlined. The first elaborate data on the genetic and epigenetic status of the above mentioned genes concerning Bulgarian patients with the sporadic form of the disease are presented. The studies indicate for a characteristic mutational spectrum in some of the genes for the Bulgarian patients and specific correlation between the status of different genes and clinicopathological characteristics.
Increasing Pursuer Capturability by Using Hybrid Dynamics
Authors: Glizer Valery Y. , Turetsky Vladimir 
Published: May 2015

Abstract
A robust interception of a maneuverable target (evader) by an interceptor (pursuer) with hybrid dynamics is considered. The controls of the pursuer and the evader are bounded. The duration of the engagement is prescribed. The pursuer has two possible dynamic modes, which can be switched once during the engagement, while the dynamics of the evader are fixed. The case where for both dynamic modes there exists an unbounded capture zone was analyzed in our previous work. The conditions under which the pursuer can increase its capturability by utilizing the hybrid dynamics were established and the new robust capture zone was constructed. In the present paper, we extend this result to the cases where at least for one dynamic mode of the pursuer the capture zone is bounded. For these instances, conditions of increasing the pursuer’s hybrid capturability are derived. Respective capture zones are constructed. Illustrative examples and results of extensive simulation for a realistic non-linear engagement model in the presence of a random wind are given.
Cortical epileptogenesis of slowly kindled freely moving rats
Authors: Orbán-Kis K. , Száva Iringó , Szilágyi T. 
Published: May 2015

Abstract
Objective. Epilepsy is a neurological disorder that can be caused by many underlying pathologies. The epileptic and interictal manifestations that appear during the progression of chronic epilepsy are still not understood completely. One of the most frequent forms of this disease is temporal lobe epilepsy in which is clear involvement of the hippocampal formation. In order to study the electrografic progression of untreated seizures we used amygdala kindling in freely moving rats. Methods. Seven animals were implanted with bilateral hippocampal and prefrontal electrodes. A bipolar electrode, implanted in the lateral nuclei of the left amygdala was used for stimulation. The kindled group of animals was stimulated daily with the minimum current intensity needed to reach the afterdischarge threshold. Behavioral changes during kindling were scored according to the Racine scale. Results. The average seizure severity on the Racine scale was 2.6±0.4 by day 6 and 4.4±0.6 by day 20. The first spontaneous seizures appeared after 31 days of stimulation. During spontaneous seizures the preictal spike full width at half maximum increased gradually from 51±4msec to 110±5msec (p < 0.05) whereas the amplitude of the negative field potential deflection increased by 62% (p < 0.05). Conclusions. Our study showed that the progression of temporal lobe epilepsy, as seen in humans, can be reproduced in the kindling model with high fidelity. This study confirms in vivo the increase in preictal spike duration as well as the increase of the amplitude of negative field potential deflection during the preictal period.
Experimental research on the interactions between some anxiolytics and dietary sodium monoglutamate
Authors: Buzescu Anca , Cristea Nicoleta Aurelia , Chiriac Alexandra , Chiriță C. 
Published: May 2015

Abstract
Objectives: Monosodium glutamate, the salt of glutamic acid, is largely used as a flavour enhancer (E621). In this study, we determine if monosodium glutamate, after repeated oral administration, can induce any degree of anxiety. Taking into account the interdependence between glutamate and GABA neurotransmissions, we studied the possible interactions of monosodium glutamate with some representatives belonging to benzodiazepines therapeutical class, diazepam and alprazolam, used as first line therapy for the treatment of anxiety. Methods: For determining the degree of anxiety, the specific cross-labyrinth test was used. The medium time spent in the closed-arms of the crosslabyrinth is correlated with increased anxiety and the medium time spent in the opened arms is correlated with a low degree anxiety. NMRI adult mice received 300 mg/kg monosodium glutamate for 21 days, dose representing 1/50 from mice LD50 (15000mg/kg) and twice the maximum admitted dose/ day for human. Results: When compared to control group, the group receiving monosodium glutamate, showed a not statistically significant slight increase in the degree of anxiety. The groups receiving benzodiazepines presented a significant reduction of the degree of anxiety, proving their anxiolytic effect. The groups receiving glutamate and diazepam or alprazolam, showed a lower reduction of the degree of anxiety, than group receiving only benzodiazepines, phenomenon which proves an antagonism between glutamate and the anxiolytics used in this study. Conclusions: The oral administration of monosodium glutamate increases slightly, not statistically significant, the degree of anxiety in mice and significantly alters the response to the benzodiazepines therapy, reducing the effect for both alprazolam and diazepam.
An unusual case of cardiac syncope and acute coronary syndrome – a case report
Authors: Chitu Monica , Benedek Theodora , Condrea S. , Blendea C. , Benedek I. 
Published: May 2015

Abstract
Introduction: We aimed to present a case of acute coronary syndrome with unexpected etiology complicated by syncope and arrhythmias, confirmed by imagistic examinations as cardiac parasitosis. Cardiac parasitic diseases are rare diseases, whose diagnosis and therapy should be adapted to each case. Imaging techniques allow precise diagnosis of cardiac echinococcosis, providing essential structural details on the damage degree of heart structures, allowing optimization of complex treatment in these cases. Case presentation: A 67-year old, obese and diabetic woman presented with cardiac syncope, arrhythmias and acute chest pain. Imagistic examinations excluded intracoronary thrombosis and confirmed a severe structural damage of myocardial tissue, consisting in replacement of the myocardial structure by many cysts caused by parasitic infestation with echinococcus multilocularis and echinoccocus granulosus originating from the liver. CT scan confirmed severe distruction of the left ventricular myocardium by policysts, that led to thinning of inferior and apical left ventricle wall without any possibility of surgical excision. Therefore a specific chemotherapy with albendazole was initiated. Follow up at 2 months indicated a favorable evolution, with serological decrease of echinococcal antibodies and reduction of cysts volume. Conclusion: In cases of angina and arrhythmias with non-atherosclerotic etiology, imaging techniques can diagnose the anatomopathological substrate of the disease and represent a valuable tool for the follow up.
Sustainable Rural Development Policy in Poland – Environmental Aspects
Authors: Mosiej Józef 
Published: May 2015

Abstract
The author discusses issues of sustainable development in rural areas in Poland from the perspective of natural resources management. Sustainable development of rural areas is the way of managing which links economic, social and ethical principles with ecological safety. This may be reached by proper management, directed on cautious usage of ecosystems’ self-controlling mechanisms, with the progress of science and technology. Agriculture in Poland is one of the most important sectors from an economic perspective and its importance is greater in Poland than in other countries in the EU. It has an influence not only on the social and economic situation of the rural population, but also on the natural environment, structure of landscape and biodiversity. From ecological point of view, functions of rural areas are not only being a place for production of food, resources for industry and green energy, but also supplying environmental goods such as protection of biodiversity and influencing air and water quality as well as landscape. The author presents ways to reduce the pressure of agricultural activities on water resources in the region, catchment and farm scale
Regional Disparities and their Reasons. Comparative Analysis of Slovakia and Hungary
Authors: Mariš Martin 
Published: May 2015

Abstract
Paper is focused on regional disparities and structural changes of economies of the V4 countries: the Slovak Republic and Hungary. The results have shown increasing regional differences between the capital regions, including their adjacent areas and the rest of the countries in case of both countries, based on empirical data and documented by the Lorenz curve. We can also observe an increasing difference between Western and Eastern areas of both countries. In terms of structural changes in the economy during the analyzed period 2001-2009, we can see a substantial shift in employment from primary sector (agriculture etc.) mainly to tertiary sector (services etc.) and also to secondary sector (industry etc.). The results are based on empirical data from secondary sources
Morphometric Characterization of Small Cell Lymphocytic Lymphoma
Authors: Chisoi Anca , Aşchie Mariana , Poinăreanu I. 
Published: May 2015

Abstract
The morphometry in histopathology is used to characterize cell populations belonging to different tissues and to identify differences in their parameters with prognostic implications. To achieve morphometric examination were selected 6 of 24 cases identified as small cell lymphocytic lymphoma. For each case analysis was done on five fields, for each field measuring the parameters of 20 cells. The studied parameters were for cytoplasm: cytoplasmic area, maximum and minimum cytoplasmic diameter, cytoplasmic perimeter; for nucleus were measured: nuclear area, minimum and maximum nuclear diameter, nuclear perimeter, nuclear contour index, nuclear ellipticity index, nuclear irregularity index. Also the nucleocytoplasmic ratio was calculated in all studied cases. Small cell lymphocytic lymphoma is characterized in morphometric terms having a small cytoplasmic area (average 29.206) and also a small nuclear area (mean 28.939) having a nucleo-cytoplasmic ratio appearance suggestive for adult lymphocyte. A nuclear contour index small value (3.946), ellipticity index value also small (3.521) and small nuclear irregularity index (3.965). Standard deviations, in any of the studied morphometric categories, is around or below 1 suggesting monomorphic cell appearance. These morphometric and microscopic features characterized mainly by a small population of adult lymphocytes, monomorphic, with rounded hipercromic nuclei, dense chromatin, support the framing into indolent lymphoma group in terms of clinical outcome.
In vitro resistance to daptomycin of staphylococcus aureus and enterococcus spp. strains
Authors: Stan Irina , Botnarciuc Mihaela , Tuţă Liliana , Gheorghe Emma 
Published: May 2015

Abstract
Daptomycin is the first antibiotic in a new class of cyclic lipopeptides, active in vitro against Gram - positive cocci. The mechanism of action is a rapid depolarization of the bacterial membrane potential, loss of cytoplasmic contents, mainly K+ ions and inhibition of protein, DNA and RNA synthesis, followed by the bacterial cell death. There were investigated 112 strains of Gram-positive cocci recommended for daptomycin susceptibility testing. Since the main clinical indications of daptomycin are the severe skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus, vancomicin-resistant enterococci and penicillinresistant Streptococcus spp, we tested daptomycin activity only in these species.
The susceptibility tests was performed by Kirby- Bauer disc-diffusion method on Muller-Hinton agar supplemented with Ca 50 mg / ml. (CAMH - Ca 2 + ) as recommended by CLSI.
During the period in which we conducted the study we isolated 112 strains of Gram-positive cocci, which we tested sensitivity to daptomycin. Resistance to Daptomycin of Staphylococcus aureus (4.11%) was lower than resistance to vancomycin (6.76%), but higher than the resistance to teicoplanin (2.71%) and linezolid (1.38%).
In our study we did not identify daptomycin resistant strains of Enterococcus spp. In severe infections that require more aggressive treatment using active antibiotics on MRSA, daptomycin is a valid therapeutic option, but a susceptibility test is required to ensure effective indication. There were no daptomycin resistant Enterococcus spp. strains
The musculocutaneous flap based on the tensor fasciae latae muscle – breast reconstruction – anatomical dissection on a cadaver
Authors: Cortan S. , Lascar I. , Valcu M. , Sebe Ioana Teona , Caraban B. , Iliescu D. 
Published: May 2015

Abstract
The cutaneous and subcutaneous defects resulting from surgical excisions are a problem and, at the same time, a challenge for surgeons. The breast is an expression of feminine beauty.
Materials and methods: Dissection on a fresh female cadaver, aged 57, in order to harvest the musculocutaneous flap based on the tensor fasciae latae muscle, from the lateral region of the thigh, using microsurgical loupes. For rendering the stages of the harvesting of the musculocutaneous flap based on the tensor fasciae latae muscle, a high-definition camera was used.
The result: the harvesting of the musculocutaneous flap based on the tensor fasciae latae muscle, and the closure of the donor area.
Conclusions: guidelines, advantages and disadvantages of using the musculocutaneous flap based on the tensor fasciae latae muscle
Evaluating The Effectiveness Of Production Process Using Pareto Analysis
Authors: Polák Pavel , Prístavka Miroslav , Kollárová Katarína 
Published: May 2015

Abstract
The aim of this paper is to present the possibilities of using the Pareto method in evaluating the effectiveness of machine production processes. The paper deals with the production process of material cutting using progressive technology and subsequent evaluation of its effectiveness and quality. In the production process, we have used the method of material cutting by abrasive water jet. The Pareto analysis was used for eliminating the shortcomings in the quality of the final part.
The Tableau Vivant as a “Figure of Return” in Contemporary East European Cinema
Authors: Pethő Ágnes 
Published: May 2015

Abstract
The paper analyses the re-conceptualization of the intermedial trope of the tableau vivant in recent East European cinema through several examples from Hungarian and Russian films directed by György Pálfi, Kornél Mundruczó, Benedek Fliegauf, Béla Tarr, and Andrei Zvyagintsev. The tableau vivant in these films is not conceived primarily as an embodiment of a painting, the introduction of “the real into the image” (as Brigitte Peucker described), instead it appears more like the objectification of bodies as images, and something that we can associate with what Mario Perniola considers the “sex appeal of the inorganic” or “the Egyptian moment in art.” As such, the tableau becomes a powerful agent in generating metanarratives, offering a blueprint for a “big picture,” a comprehensive vision of the world (reinforced by recurring mythological themes like the genesis or the end of the world, the loss of Paradise, etc.). We may connect this feature of these tableaux vivants, therefore, to what Lyotard termed as the “figure of return,” and to the reconstructive tendencies of contemporary post-postmodern art.
Intermediality between Games and Fiction: The “Ludology vs. Narratology” Debate in Computer Game Studies: A Response to Gonzalo Frasca
Authors: Kokonis Michalis 
Published: May 2015

Abstract
In the last ten or fourteen years there has been a debate among the so called ludologists and narratologists in Computer Games Studies as to what is the best methodological approach for the academic study of electronic games. The aim of this paper is to propose a way out of the dilemma, suggesting that both ludology and narratology can be helpful methodologically. However, there is need for a wider theoretical perspective, that of semiotics, in which both approaches can be operative. The semiotic perspective proposed allows research in the field to focus on the similarities between games and traditional narrative forms (since they share narrativity to a greater or lesser extent) as well as on their difference (they have different degrees of interaction); it will facilitate communication among theorists if we want to understand each other when talking about games and stories, and it will lead to a better understanding of the hybrid nature of the medium of game. In this sense the present paper aims to complement Gonzalo Frasca’s reconciliatory attempt made a few years back and expand on his proposal.
Rethinking the Perceived Self: Samples from Facebook
Authors: Kasabova Anita 
Published: May 2015

Abstract
How the self perceives reality is a traditional topic of research across several disciplines. I examine the perceived self on Facebook, as a case-study of self-knowledge on „classical” social media. Following Blascovich & Bailenson (2011), I consider the distinction between the real and the virtual as relative. Perceptual self-knowledge, filtered through social media, requires rethinking the perceived self in terms of social reality (Neisser, 1993). This claim dovetails Jenkins’s (2013) notion of the self as an active participant in consumption. I argue that the perceived self in social media could be conceived in terms of how it would like to be perceived and appraised by its virtual audience. Using Neisser’s (1993) typology of self-knowledge and Castañeda’s (1983) theory of I-guises, I analyse seven samples from Anglo-American and Bulgarian Facebook sites and show that the perceived self produces itself online as a captivating presence with a credible story. My samples are taken from FB community pages with negligible cultural differences across an online teenage/twens (twixter) age group. I then discuss some problematic aspects of the perceived self online, as well as recent critiques of technoconsumerism.
The Census, Maps, and Museums, or a Way of ‘Translating’ Identity
Authors: Mihály Vilma-Irén 
Published: May 2015

Abstract
The Census, which aims at recording pieces of information about the members of the population of a country, the historical and geographical maps drawn at the orders of the government, as well as national museums, may be more than the mere sum of the collected data to be presented. Based upon Benedict Anderson’s theory, as shown in his book entitled Imagined Communities: Reflections on the Origin and Spread of Nationalism (2006), in my paper I shall try to point at the subtle ways in which official governmental institutions have tried to use the Census, maps and museums in order to shape national identity and influence the image of a nation. Quite often what one can read about the results of the Census, what one can see on a map or encounter in a museum are not objective facts, but items placed there carefully, fulfilling specific purposes. On the one hand, they target the compatriots, on the other hand, the foreigners. Could we say that what we are dealing with here is not only an act of cultural mediation, but also a specific way of ‘translating’ identity? The next couple of pages shall try to analyze the topic and find an answer to the question above by giving examples.
Questions of Language and Culture in Erzsébet Juhász’s Border Novel
Authors: Romoda Renáta 
Published: May 2015

Abstract
The paper gives an account of the linguistic and cultural questions dealt with by Erzsébet Juhász in her novel Határregény [Border Novel]. It attempts to interpret the novel and to present the relations of its heroes to their environment. The narration covers the areas in which cultural and ethnic diversity, as well as linguistic colourfulness are present due to the coexistence of different nations. The novel’s central theme is spatial separation and separation evoked by political borders; the concept of border is introduced as early as in the novel’s title. The story of the Patarcsics is an inter-generational family story. Its members are characterized as people struggling with identity crisis and the uncertainty of national belonging. Wartime events, the behaviour and the way of thinking of families torn apart by border changes-with the mentality becoming the legacy of the next generation-are perfect reflections, illustrations of changes forced upon human lives pushed to the periphery. Not only identity and language loss, language replacement but introversion, seclusion and distantiation can also be observed at some characters. The work is exposing ruptures created by wars, and how these ruptures transform identity and cultural heritage, only to show us later how a new culture and mentality are created.
Intercultural Passages in Ottó Tolnai’s Textual Universe
Authors: Ispánovics Csapó Julianna 
Published: May 2015

Abstract
The literary palette of Tolnai’s textual universe within the Hungarian literature from Vojvodina is based, among others, upon the intertwining of various cultural entities. The social and cultural spaces of “Big Yugoslavia,” the phenomena, figures, and works of the European-oriented Yugoslav and ethnic culture (literature, painting, book publishing, theatre, sports, etc.), the mentalities of the migrant worker’s life, the legends of the Tito cult embed the narrative procedures of particular texts by Tolnai into a rich culture-historical context. Similarly to the model of Valery’s Mediterranean, the narrator’s Janus-faced Yugoslavia simultaneously generates concrete and utopian spaces, folding upon one another. Above the micro spaces (towns, houses, flats) evolving along the traces of reality, there float the Proustian concepts of scent and colour of the Adriatic sea (salt, azure, mimosa, lavender, laurel). The nostalgia towards the lost Eden rises high and waves about the “grand form” of Big Yugoslavia, the related space of which is the Monarchy. The counterpoints of the grand forms are “the small, void forms,” provinces, regions (Vojvodina, North Bačka) and the micro spaces coded into them. The text analyses of the paper examine the intercultural motions and identityforming culture-historical elements of the outlined space system.