bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development a New Method for the Determination of Chloropromazine in Trace Amounts by Fast Fourier Continuous Cyclic Voltammetry at an Au Microelectrode in a Flowing System
Authors: Norouzi Parviz , Ganjali Mohammad Reza , Farokhi Rohallah 
Published: May 2015

AbstractIn this study a new technique has been developed for the determination of chloropromazine in flow‐injection systems. The technique, named fast Fourier transformation continuous cyclic voltammetry (FFTCV), basically illustrates the benefits of sensitivity, selectivity, simplicity and low detection limit.It is also important to refer to the positive points, presented only by the use of this technique. Firstly, it is no longer necessary to remove the oxygen from the test solution. Furthermore, the quick determination of any such compound in many chromatographic methods is possible. Thirdly, the corresponding detection limit is of sub‐nanomolar level. Additionally, a special computer based numerical method is also introduced for the calculation of the analyte signal and noise reduction. The electrode response was calculated in accordance with the partial and total charge exchanges on the electrode surface, after the background current subtraction from that of noise. The integration range of currents was set for all the potential scan ranges, including oxidation and reduction of Au surface electrode, to obtain a sensitive determination.The performed experiments aimed at measuring the effects of different parameters on the method sensitivity. In the end of these measurements, it was concluded that the method was linear for the concentration range of 0.32–31900 pg/mL (r = 0.996) with a limit of detection and quantitation 0.1 and 0.32 pg/mL, respectively. For the achievement of these optimum results, the parameter values were set to 100 V/s for the scan rate, 0.4 s for accumulation time, 800 mV for accumulation potential and 2 for the pH.
NMR Studies of a Series of Shikimic Acid Derivatives
Authors: Zhang Ping , Huang Jian , Chen Fen‐Er 
Published: May 2015

AbstractThe investigations of the 1H and 13C resonances of a series of 9 shikimic acid derivatives were carried out using one‐ and two‐dimensional methods. 1H and 13C spectral data were assigned by DEPT, 1H‐1H COSY, HSQC, HMBC, and the stereo configuration was confirmed by 1D selective NOESY experiments.
An Improved Synthesis of Ceramide for Constructing α‐Galactosyl Ceramide Analogs
Authors: Yeh Chien‐Hung , Pan Si‐Der , Chen Shao‐Wei , Fu Zhi‐Wei , Chiang Li‐Wu , Yu Chung‐Shan 
Published: May 2015

AbstractIn spite of numerous synthetic routes to ceramide analogs, relatively few reports of the direct coupling of the unprotected phytosphingosine with the activated palmitic acid via amide bond formation are available. After purification by HPLC, the chromatogram indicated some impurities had not been removed during previous column chromatography. With the pure ceramides in hand, derivatization with the amino group for constructing libraries could be realized.
A Novel Spectrophotometric Method for the Determination of Zolmitriptan in Pharmaceutical Formulations
Authors: Raza Asad , Ansari Tariq Mahmood , Niazi Shahida Begum 
Published: May 2015

AbstractA simple, rapid, cost effective and extraction‐free spectrophotometric method has been developed for the determination of zolmitriptan in pharmaceutical raw and dosage forms. The method is based on the charge‐transfer reaction of zolmitriptan in acetonitrile medium with 0.2% 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone to form a colored product peaking at 555 nm. Beer's law is obeyed in the concentration range 10‐250 μg mL−1 with molar absorptivity of 1.7 × 103 L mole−1 cm−1. The effects of variables such as reagent concentration, time of reaction, color stability and interferences have been investigated to optimize the procedure. The results have been validated analytically and statistically. The proposed method has been successfully applied for the determination of zolmitriptan in pharmaceutical formulations. Results indicate that the method is accurate, precise and reproducible (relative standard deviation < 2%).
Charge Transfer Complex Role in the Formation of Chlorobenzene in the γ‐Irradiated Carbon Tetrachloride‐Benzene System
Authors: Sife‐Eldeen KH. A. , Ebraheem S. 
Published: May 2015

AbstractThe formation of carbon tetrachloride‐benzene charge transfer complex was confirmed by UV and NMR spectrometric studies. A change in UV spectrum of benzene is observed upon addition of carbon tetrachloride. Whereas the appearance of new bands supports the formation of charge transfer complex. NMR study shows that, chemical shift of benzene pmr signal depends on the CCl4‐C6H6 molar ratio. This observation is another criterion for the formation of benzene‐carbon tetrachloride charge transfer complex. Job's Continuous Variation method indicates that a 2:1 CCl4‐C6H6 charge transfer complex (2:1 CTC) is formed. The association constants (K2:1) of (2:1 CTC) was found to be 0.0197 M−2. The maximum concentration of (2:1 CTC) was found to be in samples with 2:1 CCl4‐C6H6 molar ratio (33% benzene mole). On the other hand the maximum yield of chlorobenzene was obtained, also, upon radiolysis of CCl4‐C6H6 samples at a 2:1 molar ratio (33% benzene mole). Therefore, it could be concluded that (2:1 CTC) participates in the formation of chlorobenzene upon radiolysis of the benzene‐carbon tetrachloride system. This conclusion was supported by the dependence of the chlorobenzene yield of a γ‐irradiated carbon tetrachloride‐benzene system (2:1 molar ratio) on irradiation time according to a third order kinetic equation with a very good linearity (R2 = 0.9977). Accordingly, the rate constant for the chlorobenzene formation under this condition was found to be ≈ 5.5 × 10−7 L2.mol−2.h−1. We propose a radiation chemical mechanism in which the 2:1 CTC plays a role in the formation of chlorobenzene.
Theoretical Study on the Intermolecular Interactions between 1,1‐Diamino‐2,2‐Dinitroethylene and H2O
Authors: Sun Xiao‐Qiao , Ju Xue‐Hai , Xu Xiao‐Juan , Fan Xiao‐Wei 
Published: May 2015

AbstractThe density functional method was applied to the study of 1,1‐diamino‐2,2‐dinitroethylene (Fox‐7)/H2O dimer. All the possible dimers (1, 2 and 3), as well as the monomers, were fully optimized with the DFT method at the B3LYP/6‐311++G** level. The basis set superposition errors (BSSE) are 4.62, 4.07 and 3.45 kJ/mol, and the zero point energy (ZPE) corrections for the interaction energies are 7.94, 5.66 and 6.40 kJ/mol for 1, 2 and 3, respectively. Dimer 1 is the most stable, judged by binding energy. After BSSE and ZPE corrections, the greatest corrected intermolecular interaction energy of dimer 1 was predicted to be −29.36 kJ/mol. The charge redistribution mainly occurs on the adjacent N–H··· O atoms and N–O··· H atoms between submolecules. The oxygen in the nitro group acts as a moderate hydrogen acceptor as compared to water oxygen. Based on the statistical thermodynamic method, the standard thermodynamic functions, heat capacities (C0P), entropies (S0T) and thermal corrections to enthalpy (H0T), and the changes of thermodynamic properties on going from monomer to dimer over the temperature range 200.00‐700.00 K were predicted. It is energetically or thermodynamically favorable for Fox‐7 to bind with H2O and to form dimer 1 at room temperature.
The Fock Matrix Analysis for Atomic Orbitals in Molecular Orbitals I. A New Look on the Covalent Bond in H2?
Authors: Hsu Wen‐Yi , Lee Hsing‐Yi , Wang Shao‐Pin , Chang Tse‐Chiang 
Published: May 2015

AbstractThe character of the molecular orbitals can be better accounted for in terms of molecular adapted atomic orbitals and the Fock matrix expanded in these atomic orbital sets. A clean‐cut and unique criterion for the diradicals and the covalent bonds can be given for the molecular orbitals in both restricted and unrestricted Hartree‐Fock wavefunctions. Instead of the picture that overlap charge migrates into the bonding region, the new analysis displays another picture that the charge densities for the electrons with α and β spins give rise to two opposite spin density shifts. If the α one shifts from atom A toward atom B then it is vice versa for the β one. The spin density shifts proceed until the bonding molecular orbitals form.
A Straightforward Method for the Synthesis of Functionalized Trisubstituted Alkenes through Na2S/Al2O3 Catalyzed Knoevenagel Condensation
Authors: Heravi Majid M. , Bakhtiari Khadijeh , Taheri Shima , Oskooie Hossein A. 
Published: May 2015

AbstractNa2S/Al2O3 catalyzed the Knoevenagel condensation between an aldehyde and an active methylene compound to yield various trisubstituted alkenes.
An Efficient Synthesis of Sulfonylhydrazides and Sulfonylsemicarbazides by Utilizing Alumina as a Catalyst
Authors: Safaei‐Ghomi Javad 
Published: May 2015

AbstractSulfonyl hydrazides and sulfonyl semicarbazides are readily prepared by the reacting of hydrazine derivatives with sulfonyl chlorides in the presence of basic alumina under solvent‐free conditions. Reaction of a sulfonyl chloride with t‐butylcarbazate, followed by hydrolysis provides the corresponding sulfonyl hydrazides in higher yield and shorter time than previously reported.
A New Ellagitannin from the Fruit of Phyllanthus Emblica L.
Authors: Yang Chun‐Bin , Zhang Fan , Deng Mei‐Cai , He Guang‐Yun , Yue Jian‐Min , Lu Run‐Hua 
Published: May 2015

AbstractA new ellagitannin along with eight known compounds has been isolated from the ethanol extract of the fruit of Phyllanthus emblica L. The chemical structure of the new compound was established as Phyllanthunin (1) by HR‐ESI‐MS, 1D and 2D NMR spectroscopic analysis.
TBAF‐Mediated Dimerization Reaction of β,γ‐Unsaturated Arylketones
Authors: Chang Meng‐Yang , Hung Chin‐Yi , Lin Shiang‐Tsern 
Published: May 2015

AbstractA simple and high‐yield method for the synthesis of several 1,5‐diaryl‐1,5‐dicarbonyl compounds has been established starting from TBAF‐mediated isomerization and dimerization reaction of β,γ‐unsaturated arylketones (allyl arylketones) with mono‐, di‐, and tri‐methoxy groups, which is derived from allylation of commercially available different benzaldehydes and followed by oxidation of the resulting secondary alcohols.
A Novel Inorganic Clathrate Generated through Arene‐Arene Interactions
Authors: Mao Shih‐Hsuan , Liu Shih‐An , Liao Fen‐Ling , Shiu Kom‐Bei 
Published: May 2015

AbstractThe direct mixing of CoCl2, sodium 2,6‐pyridinedicarboxylate (Na2(2,6‐pda)), KSCN, and 1,2‐bis(4‐pyridyl)ethane (bpye) in water at the ambient temperature afforded purple crystals readily. The crystal structure, as determined by X‐ray diffraction crystallography, consists of discrete inorganic [Co2(η3‐2,6‐pda)2(μ‐SCN)2(H2O)2] and organic bpye molecules. Adjacent dicobalt molecules are connected via intermolecular hydrogen bonds, to form one‐dimensional hydrophobic channels in the solid state, which serve as a host framework to incarcerate bpye guests inside. Every organic molecule attaches to four adjacent inorganic species via arene‐arene interactions. The facile approach in assembling the dicobalt and bpye molecules together into an inorganic clathrate is demonstrated.
Transfer Thermodynamics of Protein in Denaturing and Stabilizing Media
Authors: Chatterjee Someswar , Basumallick I. 
Published: May 2015

AbstractFree energies of transfer (ΔGt) of RibonucleaseA (RNaseA) from water to aqueous solutions of urea (4 M, 6 M and 8 M), a protein denaturing solvent as well as ΔGt of RibonucleaseA, β‐Lactoglobulin, α‐Chymotripsin and ChymotrypsinogenA from water to aqueous glycerol (10%, 20%, 30% and 40%), a protein stabilizing solvent has been dissected into cavity term [ΔGt(cav)] and interaction term [ΔGt(int)]. The interaction free energy includes all types of interactions like hard‐soft, hydrogen bonding, electrostatic, etc. The cavity forming free energies have been calculated using the standard version of scaled particle theory (SPT) with well‐reported SPT parameters. It has been found that transfer free energies of cavity terms ΔGt(cav) for native protein from water to urea‐water and water to aqueous glycerol follow almost opposite trends. This primarily indicates there may be some correlation between cavity creation energies and protein denaturing and stabilizing ability of a solvent. The results are in agreement with those obtained from preferential binding coefficient studies in these media.
Ultrafast Spectroscopy Studies on Thickness Dependence of Acoustic Phonon Modes in Silver Nanoprisms
Authors: Yu Pyng , Shiu Ying‐Jen , Chen Yit‐Tsong , Lin Sheng‐Hsien 
Published: May 2015

AbstractTime‐resolved transient absorption technique is used to investigate the thickness dependence of acoustic phonon modes of silver nanoprisms with two thicknesses, 7.8 ± 1.2 and 8.5 ± 0.69 nm, and a similar bisector length of 31.4 ∼ 31.6 nm. Coherent acoustic phonon signals are observed. A new acoustic phonon frequency within 7.81 cm−1 ∼ 11.7 cm−1 is found and this phonon mode is associated with the thickness of the nanoprism. Another phonon frequency between 1.95 cm−1 and 1.71 cm−1 is also observed, and its origin can be associated with the bisector length of the nanoprism.
Synthesis, Structure and Magnetic Properties of 1‐D Silver(I) Complexes with Benzoic Acids Bearing Ortho‐Imino Nitroxide and Para‐Nitronyl Nitroxide Radical Ligands
Authors: Lin Hsin‐Huang , Wei Ho‐Hsiang 
Published: May 2015

AbstractTwo new 1‐D silver(I) complexes, [Ag(I)1.5(IM‐oBA)(NO3)0.5] (1) and [Ag(I)(NIT‐pBA)] (2), (IM‐oBAH = 2‐(2‐carboxyphenyl)‐4,4,5,5‐tetramethyl‐4,5‐dihydro‐1H‐imidazol‐1‐yloxyl, NIT‐pBAH = 2‐(4‐carboxyphenyl)‐4,4,5,5‐tetramethyl‐4,5‐dihydro‐3‐oxido‐H‐imidazol‐3‐ium‐1‐yloxyl) have been prepared and structurally characterized. Complexes 1 and 2 crystallized in the monoclinic space groups of C2/c and P21/c, respectively. In complex 1, the structure consists of trinuclear Ag(I) atoms with different linkages of IM‐oBA and nitrates. The trinuclear Ag(I) atoms are further coordinated to the neighbor IM‐oBA radicals via self‐assembly of the nitrogen atom of imine moiety and extended into formation of a polymeric chain. Complex 2 is constructed from a bis(carboxylato‐O,O')‐bridged centrosymmetric dimeric subunit and extended into a polymeric chain through self‐assembly coordination between metal ions and nitroxide groups of NIT‐pBA radicals. Temperature dependence of magnetic susceptibility measurements showed a weak ferromagnetic coupling between nitroxide radicals in 1 and 2 with J = 5.62 for 1 and 6.62 cm−1 for 2, respectively.
Heterodinuclear Replacement Complexation for Sensitive Determination of Iron Ion in Surface Water with Dibromocarboxyarsenazo
Authors: Zeng Teng , Pan Lu‐Ting , Gao Hong‐Wen 
Published: May 2015

AbstractDibromocarboxyarsenazo (DBCA) was used to complex Fe and Cu ions at pH 6.22, and complexes Cu(DBCA) and Fe(DBCA) were formed. Fe ion replaced Cu competitively from its dinuclear complex Cu(DBCA)Cu to form the heterodinuclear complex, Cu(DBCA)Fe. The light‐absorption ratio variation approach has been applied to the direct determination of Fe ions with a high selectivity and good sensitivity using heterodinuclear replacement complexation. The limit of detection of Fe is only 2.5 ng/mL. The results from the analyses of five Huangpu River (Shanghai) cross‐section samples indicate that Fe ions are from 5.0 to 39.2 μg/L with the recovery rates between 85.5 and 111.5%.
The Fock Matrix Analysis for Atomic Orbitals in Molecular Orbitals II. The Electronic Structure of N2 Molecules
Authors: Hsu Wen‐Yi , Lee Hsing‐Yi , Wang Shao‐Pin , Chang Tse‐Chiang 
Published: May 2015

AbstractWeinhold's natural hybrid orbitals can be chosen as the molecular adapted atomic orbitals to build the canonical molecular orbitals of N2 molecules. The molecular Fock matrix expanded in the natural hybrid orbitals can reveal deeper insight of the electronic structure and reaction of the N2 molecule. For example, the magnitude of Fab can signify the bonding character of the paired electrons as well as the diradical character of the unpaired electrons for both σ‐ and π‐types. Discarding the concept of the overlap between non‐orthogonal atomic orbitals, the different orbitals for different spins in the unrestricted Hartree‐Fock wavefunction reveal that there are three pairs of opposite spin density flows between two atoms, which proceed until the bonding molecular orbitals form.
Applications of Carbohydrate‐Gold Nanoparticles for Volumetric Flow Measurements Using an Opto‐Acoustic Technique
Authors: Yang Chan‐Yi , Wei Chen‐Wei , Lin Yen‐Ping , Tseng Hsiao‐Chien , Wu Ya‐Na , Chen Chia‐Chun , Shieh Dar‐Bin , Li Pai‐Chi 
Published: May 2015

AbstractGold nanoparticles with carbohydrate ligands attached on their surface have been synthesized and characterized with various techniques. The new nanoparticle conjugates have shown great potentials as a contrast agent for opto‐acoustic imaging. Hemocompatibility measurements of human blood for the carbohydrate‐gold nanoparticles have shown that the conjugates are feasible for in vivo testing. Preliminary quantitative flow measurements using the conjugates were also studied in this work based on the indicator‐dilution theory. In vitro phantom experiments were designed and conducted, and results were discussed.
Interaction of Bovine Serum Albumin with N‐(4‐Ethoxyphenyl)‐N′‐(4‐Antipyrinyl)Thiourea (EPAT) Using Spectroscopies
Authors: Cui Feng‐Ling , Cui Yan‐Rui , Wang Jun‐Li , Fan Jing , Li Jian‐Ping , Lu Yan 
Published: May 2015

AbstractThe interaction between N‐(4‐ethoxyphenyl)‐N′‐(4‐antipyrinyl)thiourea (EPAT) and bovine serum albumin (BSA) was studied by fluorescence spectroscopy in combination with UV absorption spectroscopy. The intrinsic fluorescence of bovine serum albumin was quenched by EPAT through a static quenching procedure. The binding constants of EPAT with BSA were estimated according to the fluorescence quenching results at different temperatures. The thermodynamic parameters: enthalpy change (ΔH) and entropy change (ΔS) were calculated to be −10.69 kJ/mol and 42.64 J·mol−1·K−1 according to thermodynamic equations, respectively, and indicating that the binding force was suggested to be mainly a hydrophobic force. The effect of common ions on the binding constant was also investigated. A new fluorescence spectroscopy assay of the proteins was presented in this paper. The determination results of the proteins in bovine serum by means of this method were very close to those obtained using Coomassie Brilliant Blue G‐250 colorimetry.
Synthesis of Endo,Endo‐2.9‐Dihydroxypentacyclo‐[8.4.0.03,8.04,14.07,11]Tetradeca‐5,12‐Diene
Authors: Chou Teh‐Chang , Lin Gerng‐Horng , Wu Sen‐Ching , Bahekar Sushilkumar S. 
Published: May 2015

AbstractThe title compound 30 was synthesized starting from the endo,syn,endo Diels‐Alder adduct 3a of hexahydro‐5,6,7,8‐tetrachloro‐9,9‐dimethoxy‐5,8‐methanonaphthalene‐1,4‐diol diacetate 6 and 1,2,3,4‐tetrachloro‐5,5‐dimethoxycyclopentadiene (TDCp) in six steps, keyed upon a symmetry‐allowed [4+4] photocyclization of decahydro‐11,12‐dioxo‐[1,4;5,8]dimethanoanthracene‐9,10‐diol diacetate 22. The epimeric monoacetate 26 related to 22 was also synthesized and their thermolysis and photolysis were investigated. Oxidation of diol 30 afforded hexacyclic bridged hemiacetal 31 as a result of transannular reaction. The structure of hemiacetal 31 was analyzed by single‐crystal X‐ray crystallography.
Synthesis, Crystal Structure and Density Functional Studies on 1N‐Phenyl‐3‐(2,4‐Dichlorophenyl)‐5‐(4‐Chlorophenyl)‐2‐Pyrazoline
Authors: Zhao Pu‐Su , Guo Huan‐Mei , Wang Xian , Jian Fang‐Fang 
Published: May 2015

Abstract1N‐Phenyl‐3‐(2,4‐dichlorophenyl)‐5‐(4‐chlorophenyl)‐2‐pyrazoline has been synthesized and characterized by elemental analysis, IR, UV‐Vis and X‐ray single crystal diffraction. Density functional calculations have been carried out for the title compound by using the B3LYP method with a 6‐311G** basis set. The calculated results show that the predicted geometry can reproduce well the structural parameters. The electronic absorption spectra calculated in the gas phase are better than those calculated in EtOH solvent to model the experimental electronic spectra. Natural Bond Orbital (NBO) analyses suggest that the above electronic transitions are mainly assigned to π → π* transitions. On the basis of vibrational analyses, the thermodynamic properties of the compound at different temperatures have been calculated, revealing the correlations between C0p, m, S0m, H0m and temperature.
Synthesis and Characterization of Novel Organosoluble Polychloro Substituted Aromatic Poly(Ether Ketone)s
Authors: Sheng Shou‐Ri , Mao Xue‐Chun , Pei Xue‐Liang , Liu Xiao‐Ling , Song Cai‐Sheng 
Published: May 2015

AbstractA novel monomer of tetrachloroterephthaloyl chloride (TCTPC) was prepared by the chlorination of terephthaloyl chloride catalyzed by ferric chloride at 175‐180 °C for 10 h, and confirmed by FTIR, MS and elemental analysis. A series of new polychloro substituted poly(aryl ether ketone)s with inherent viscosities of 0.58‐0.65 dL/g have been prepared from TCTPC with aromatic ether monomers by electrophilic Friedel‐Crafts acylation in the presence of DMF with anhydrous AlCl3 as a catalyst in 1,2‐dichloroethane. Glass‐transition temperatures of these polychlorinated polymers ranged from 267 to 280 °C by DSC. The degradation temperature at 5% weight loss by TGA in nitrogen for these polymers ranged from 486 to 534 °C, and the char yields at 700 °C were 54‐65%. The polymers having a weight‐average molecular weight in the range of 65,900‐79,300 are all amorphous and readily soluble in polar solvents such as DMF, DMSO and NMP at room temperature. All the polymers formed transparent, strong, and flexible films, with tensile strengths of 86.1‐99.7 MPa, Young's moduli of 2.32‐3.35 GPa, and elongations at break of 10‐15%.
Insulin Surface Acoustic Wave Immunosensor Based on Immobilized C60/Anti‐Insulin Antibody
Authors: Chang Hung‐Wei , Shih Jeng‐Shong 
Published: May 2015

AbstractImmobilized fullerene C60/anti‐insulin antibody was prepared and applied in shear horizontal surface acoustic wave (SH‐SAW) immunosensors to detect insulin in aqueous solutions. The immobilizations of anti‐insulin onto fullerene were studied through a C60/PVC coated SH‐SAW sensor system in liquid. The partially irreversible frequency response for an anti‐insulin antibody was observed by the desorption study, which implied that fullerene could chemically react with anti‐insulin. C60/anti‐insulin coating materials were successfully prepared and identified with an FTIR spectrometer. The C60/anti‐insulin coated SH‐SAW immunosensors were developed and applied for detection of insulin in aqueous solutions. Within the range of normal human insulin concentration, the SH‐SAW immunosensors immobilized with C60/anti‐insulin exhibited linear frequency responses to the concentration of insulin with a sensitivity of 130 Hz/pM. The SH‐SAW immunosensor immobilized with C60/anti‐insulin showed a detection limit of 0.58 pM for insulin in aqueous solution. The interference of various common bio‐species in human blood, e.g. urea, ascorbic acid, tyrosine, and metal ions, to the SH‐SAW immunosensor immobilized with C60/anti‐insulin for insulin was investigated. These common bio‐species interferences showed nearly no interference to the SAW immunosensors coated with C60/anti‐insulin. The reproducibility of the SH‐SAW immunosensor immobilized with C60/anti‐insulin for insulin was also investigated and is discussed.
Preparation of 1H‐1,2,3‐Triazoles by Cuprous Ion Mediated Cycloaddition of Terminal Alkyne and Sodium Azide
Authors: Lu Li‐Hui , Wu Jia‐Hao , Yang Chia‐Hsi 
Published: May 2015

Abstract1H‐1,2,3‐triazoles can be prepared in good yield by the reaction of terminal alkyne and sodium azide in the presence of cuprous chloride at a temperature higher than 70°C. The alkyne is unactivated and the reaction has to be carried out under inert gas. At room temperature, the reaction first gives a Cu(I)‐azide complex which is converted to a Cu‐alkyne complex when the temperature is raised to higher than 70°C. The reaction of Cu(I)‐alkyne complex and azide ion dissociated from or coordinated to Cu(I) then gives 1H‐1,2,3‐triazoles.