bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Applications of Herbal-Based Nanocosmeceuticals for Beauty and Skin Therapy
Authors: Shree Dipthi , Patra Chinam Niranjan , Sahoo Biswa Mohan 
Published: July 2024

:
Herbal cosmeceuticals are a rapidly expanding sector of the personal care industry,
and their use has greatly expanded over time. The advancement of research and development is
demonstrated by nanotechnology, which boosts product efficacy by delivering innovative solutions.
The application of nanotechnology is growing in the field of cosmeceuticals to address
numerous shortcomings of conventional herbal products. Lower penetration and high compound
instability of various cosmetic products for prolonged and enhanced compound delivery to
beauty-based skin therapy are the main problems with the use of phyto-based cosmeceuticals.
Nanosized delivery technologies are currently being used in cosmeceutical industries and products
for prolonged and improved delivery of phyto-derived bioactive chemicals to solve these
drawbacks. The aseptic sensation of many cosmeceutical products is improved by nanosizing
phytocompounds, which also improve skin-protective properties and sustained delivery. Nanocosmeceuticals
are now commonly utilized on skin, hair, lips, and nails to treat disorders including
wrinkles, photoaging, hyperpigmentations, dandruff, hair damage, chapped lips, etc. Some of
the cutting-edge nanotechnologies now being used for improved delivery of the phytoconstituents
in skin care therapy include liposomes, ethosomes, glycerosomes, transferosomes, niosomes,
phytosomes, nanostructured lipid carriers, solid lipid nanoparticles, polymeric nanoparticles,
nanoemulsions, nanogels, etc. The advantages of these novel nanocarriers include improved skin
penetration, controlled and prolonged drug release, increased stability, site-specific targeting,
high entrapment efficiency, and improved bioavailability. Several phytoconstituents such as curcumin,
aloe vera, resveratrol, lycopene, tocopherol, quercetin, catechins, and lutein have been
successfully nanosized by employing various delivery technologies and incorporated in various
gels, lotions, and creams for skin, lip, hair, and nail care for their sustained effects. The present
article primarily focuses on the use of phytocompounds in various cosmeceutical products, diverse
classes of innovative nanocarriers employed for delivering herbal nanocosmeceuticals, and
the use of various phytobioactive compounds in novel nanocosmeceutical formulations to improve
skin-based therapy.
A Comparative Study of Dexamethasone and Methylprednisolone in COVID-19 Patients: Clinical Outcomes and Inflammatory Markers
Authors: Moghaddam Alireza Ziaei , Soleimani Mostafa , Imani Behnam , Hejazi Sepide , Taherynejad Mohammadhossein , Kabiri Mona , Emadzadeh Maryam , Ravanshad Sahar 
Published: July 2024

Background:
The Coronavirus disease 2019 (COVID-19) pandemic, prompted by
SARS-CoV-2, has created complicated health crises. An excessive inflammatory response and cytokine
storm characterize severe COVID-19. Corticosteroids like dexamethasone and methylprednisolone
are used for their anti-inflammatory effects, but comparisons of their efficacy are lacking.

Objective:
This study seeks to rigorously assess and contrast the effectiveness of dexamethasone
and methylprednisolone in combating COVID-19 infections.

Methods:
This retrospective clinical study evaluates the effects of these two corticosteroids by reviewing
the files of 500 hospitalized COVID-19 patients. The baseline characteristics of the patients,
chest CT severity score, type of steroid prescription, duration of hospitalization and steroid
prescription, dosage of corticosteroid therapy, their recovery status, hospital mortality, and specific
disease severity-associated markers, such as lactate dehydrogenase (LDH), complete blood
count (CBC), C-reactive protein (CRP), and Erythrocyte sedimentation rate (ESR) were collected
and compared.

Results:
The study found no significant difference in most disease severity-associated markers between
the two corticosteroid groups. However, lower mortality rates and shortened hospital stays
were significantly associated with dexamethasone, especially in critical patient groups. A detailed
analysis of inflammatory markers suggested minimal differences based on the type of corticosteroid
used.

Conclusion:
The study indicates that dexamethasone may have some advantages in specific clinical
outcomes. Further research needs to explore the mechanisms involved despite similar anti-inflammatory
profiles.
Decoding Acne Vulgaris: Insights into Pathogenesis, Treatment Modalities, Diagnosis and Recent Advancements
Authors: Guleria Priyanka , Joshi Shiana , Parmar Shivika , Sharma Tarun , Chaudhary Archana , Kumar Pravin , Ashawat Mahendra Singh 
Published: July 2024

Background:
Acne vulgaris, an alternative term for acne, is a persistent inflammatory
skin condition affecting the pilosebaceous unit. Its development involves a combination of factors,
including increased sebum production, changes in keratinization leading to comedone formation,
colonization of hair follicles by Propionibacterium acnes (P. acnes), and the release of inflammatory
mediators in the vicinity of the pilosebaceous unit.

Objective:
This review provides a concise overview of acne, covering its pathogenesis, epidemiology,
diagnosis, treatment options, and recent advancements involved in acne.

Discussion:
Various therapeutic approaches, encompassing topical, systemic, combination, and
hormonal treatments, are employed to address acne. Prolonged use of synthetic medications is
common in acne therapy, but their potential for severe side effects prompts a preference for herbal-
based treatments. Herbal remedies utilizing extracts of natural origin are considered safer due
to their lower toxicity and reduced likelihood of adverse drug reactions. Recent advancements, particularly
in personalized medicine and microbiome research have enhanced our understanding and
opened new avenues for more effective management.

Conclusion:
Decoding acne vulgaris has provided insights into its pathogenesis, treatment modalities,
diagnostics, and recent advancements. Integrating synthetic and herbal treatments, personalized
medicine, microbiome research, and advanced modeling techniques offer promising acne management
strategies.
Web-Based Warfarin Management (Alfalfa App) Versus Traditional Warfarin Management: Multicenter Prospective Cohort Study
Authors: Chen Wenfei , Chen Jiana , Jiang Shaojun , Wang Chunhua , Zhang Jinhua 
Published: July 2024

Background
Poor anticoagulation management of warfarin may lead to patient admission, prolonged hospital stays, and even death due to anticoagulation-related adverse events. Traditional non–web-based outpatient clinics struggle to provide ideal anticoagulation management services for patients, and there is a need to explore a safer, more effective, and more convenient mode of warfarin management.

Objective
This study aimed to compare differences in the quality of anticoagulation management and clinical adverse events between a web-based management model (via a smartphone app) and the conventional non–web-based outpatient management model.

Methods
This study is a prospective cohort research that includes multiple national centers. Patients meeting the nadir criteria were split into a web-based management group using the Alfalfa app or a non–web-based management group with traditional outpatient management, and they were then monitored for a 6-month follow-up period to collect coagulation test results and clinical events. The effectiveness and safety of the 2 management models were assessed by the following indicators: time in therapeutic range (TTR), bleeding events, thromboembolic events, all-cause mortality events, cumulative event rates, and the distribution of the international normalized ratio (INR).

Results
This national multicenter cohort study enrolled 522 patients between June 2019 and May 2021, with 519 (99%) patients reaching the follow-up end point, including 260 (50%) in the non–web-based management group and 259 (50%) in the web-based management group. There were no observable differences in baseline characteristics between the 2 patient groups. The web-based management group had a significantly higher TTR than the non–web-based management group (82.4% vs 71.6%, P<.001), and a higher proportion of patients received effective anticoagulation management (81.2% vs 63.5%, P<.001). The incidence of minor bleeding events in the non–web-based management group was significantly higher than that in the web-based management group (12.1% vs 6.6%, P=.048). Between the 2 groups, there was no statistically significant difference in the incidence of severe bleeding and thromboembolic and all-cause death events. In addition, compared with the non–web-based management group, the web-based management group had a lower proportion of INR in the extreme subtreatment range (17.6% vs 21.3%) and severe supertreatment range (0% vs 0.8%) and a higher proportion in the treatment range (50.4% vs 43.1%), with statistical significance.

Conclusions
Compared with traditional non–web-based outpatient management, web-based management via the Alfalfa app may be more beneficial because it can enhance patient anticoagulation management quality, lower the frequency of small bleeding events, and improve INR distribution.
Preferences for COVID-19 Vaccines: Systematic Literature Review of Discrete Choice Experiments
Authors: Huang Yiting , Feng Shuaixin , Zhao Yuyan , Wang Haode , Jiang Hongbo 
Published: July 2024

Background
Vaccination can be viewed as comprising the most important defensive barriers to protect susceptible groups from infection. However, vaccine hesitancy for COVID-19 is widespread worldwide.

Objective
We aimed to systematically review studies eliciting the COVID-19 vaccine preference using discrete choice experiments.

Methods
A literature search was conducted in PubMed, Embase, Web of Science, Scopus, and CINAHL Plus platforms in April 2023. Search terms included discrete choice experiments, COVID-19, and vaccines and related synonyms. Descriptive statistics were used to summarize the study characteristics. Subgroup analyses were performed by factors such as high-income countries and low- and middle-income countries and study period (before, during, and after the pandemic wave). Quality appraisal was performed using the 5-item Purpose, Respondents, Explanation, Findings, and Significance checklist.

Results
The search yield a total of 623 records, and 47 studies with 53 data points were finally included. Attributes were grouped into 4 categories: outcome, process, cost, and others. The vaccine effectiveness (21/53, 40%) and safety (7/53, 13%) were the most frequently reported and important attributes. Subgroup analyses showed that vaccine effectiveness was the most important attribute, although the preference varied by subgroups. Compared to high-income countries (3/29, 10%), a higher proportion of low- and middle-income countries (4/24, 17%) prioritized safety. As the pandemic progressed, the duration of protection (2/24, 8%) during the pandemic wave and COVID-19 mortality risk (5/25, 20%) after the pandemic wave emerged as 2 of the most important attributes.

Conclusions
Our review revealed the critical role of vaccine effectiveness and safety in COVID-19 vaccine preference. However, it should be noticed that preference heterogeneity was observed across subpopulations and may change over time.

Trial Registration
PROSPERO CRD42023422720; https://tinyurl.com/2etf7ny7
Hubungan Antara Panjang Tungkai dan Daya Ledak Otot Tungkai Terhadap Kecepatan Lari 50 Meter
Authors: Kurniawan Alexander , Haryanto Deri , Sukendro Sukendro 
Published: July 2024

Tujuan penelitian ini yaitu untuk mengetahui hubungan panjang tungkai dan daya ledak otot tungkai terhadap kecepatan lari 50 meter pada siswa putra SMP Negeri 2 Kerinci. Penelitian ini menggunakan metode korelasi, dalam penelitian ini penelitian ini adalah penelitian korelasional dengan pengambilan datanya dilakukan dengan tes dan pengukuran, dalam metode ini peneliti berusaha menggambarkan dengan sejelas-jelasnya mengenai panjang tungkai dan daya ledak otot tungkai dengan prestasi lari 50 Meter. Sampel dilakukan ditujukan kepada siswa putra yang berjumlah 45 orang secara total sampel. Berdasarkan analisis data yang diperoleh variabel X1 terhadap Y mudah dilihat bahwa t hitung 12,9749 > t tabel 1,6811 maka terdapat hubungan antara panjang tungkai dengan kecepatan lari 50 meter. Variabel X2 terhadap Y dilihat bahwa t hitung 5,266207 > t tabel 1,6811 maka terdapat hubungan antara daya ledak otot tungkai dengan kecepatan lari 50 meter. Untuk variabel X1 dan X2 Terhadap Y diketahui r hitung = 0,893574. Kemudian data tersebut diuji signifikansi korelasi dengan dibandingkan rtabel pada taraf signifikansi 5% = 0,294 yang berarti r hitung > r tabel. Dengan demikian dapat disimpulkan terdapat hubungan antara panjang tungkai dan daya ledak otot tungkai terhadap kecepatan lari 50 meter pada siswa putra SMP Negeri 2 Kerinci
Modelo sistema de gestión de seguridad de la información para instituciones educativas de nivel básico
Authors: Blandón Jaramillo Carlos Arturo , Benavides Sepúlveda Alejandra María 
Published: July 2024

El Ministerio de Tecnologías de la Información y las Comunicación – MINTIC ha establecido directrices que permiten implementar sistemas de gestión de seguridad de la información – SGSI en las entidades del estado. La educación pública es un servicio y un derecho de los niños y niñas consagrado en la Constitución Política de Colombia, circunscrito en el Decreto Reglamentario 1078/2015, que contiene a su vez lo lineamientos para la implementación de la estrategia de gobierno en línea – GEL, incluyendo un SGSI basado en la norma NTC ISO/IEC 27001. El proyecto consiste en realizar un análisis de riesgos con base en la norma ISO 27005 identificando los activos críticos del área de secretaría académica de las instituciones educativas – IED’s de nivel básico y los riesgos asociados, para generar un plan de tratamiento de riesgos que permita proponer una declaración de aplicabilidad, así mismo analizar la normatividad del Ministerio de Educación, del MINTIC y los requisitos de la norma NTC ISO/IEC 27001 que permitan proponer un modelo general que facilite la implementación de un SGSI en este tipo de instituciones. El modelo resultante cumple con los requisitos obligatorios establecidos en la norma NTC ISO/IEC 27001, y constituye una base para garantizar la disponibilidad, integridad y confidencialidad de la información sensible de los niños, cumpliendo las disposiciones pertinentes del sector educación, sector TIC componente seguridad y privacidad de lainformación.
Programación por demostración del agarre de objetos empleando técnicas basadas en modelo de mezcla de Gausianas
Authors: Hoyos Gutierrez Jose Gabriel , Navarro Pérez Alvaro Andrés 
Published: July 2024

Se presenta una técnica que permite agarrar un objeto empleando la combinación de técnicas de programación por demostración. Las técnicas son el modelo de mezcla de gaussianas parametrizado en la tarea y el modelo de mezcla de gaussianas. Con la primera se estima la trayectoria de la mano para una nueva posición y orientación del objeto, el valor final obtenido de posición y orientación no siempre es exacto, por lo que se aplica un segundo paso o paso de corrección empleando el modelo de mezcla de gaussianas. A través de un experimento real se obtiene una base de datos de demostraciones de agarres y se prueba el algoritmo propuesto. Luego empleando evaluación subjetiva de la calidad del agarre y gráficas del error se muestra que la técnica presentada mejora la respuesta lograda al solo emplear el modelo de mezcla de gaussianas parametrizado en la tarea.
Applying Large Language Models in Accounting: A Comparative Analysis of Different Methodologies and Off-the-Shelf Examples
Authors: Li Huaxia , Vasarhelyi Miklos A. 
Published: July 2024

ABSTRACT
The emergence of large language models (LLMs) presents significant opportunities in accounting, including optimizing current processes, extracting new information, and updating accounting measurements. However, factors such as skill gaps, perceived complexity of integration, and cost constraints have limited the implementation of LLMs in accounting. This study provides an overview of mainstream LLM utilization methods, including user interface and application programming interface, and introduces a novel approach via robotic process automation integration. The advantages and limitations of each method are discussed, accompanied by a current analysis of the time, labor, and monetary costs involved in using LLMs for accounting tasks. To facilitate practical applications, three off-the-shelf examples are provided. This study contributes to the literature and practice by summarizing and comparing LLM implementation methods, responding to the challenges raised by researchers and stakeholders, and bridging the gap between technology innovation and its practical application in accounting.
JEL Classifications: M41; O14; O33; D61.
The Effect of the Current Expected Credit Loss Model on Conditional Conservatism of Banks and Its Spillover Effect on Borrower Conservatism
Authors: Qiang Xinrong , Wang Jing 
Published: July 2024

ABSTRACT
Under the Current Expected Credit Loss (CECL) model, banks should fully recognize expected lifetime credit losses upon loan origination while gradually recognizing interest revenues. This timelier recognition of losses versus gains (i.e., conditional conservatism) makes banks more capital constrained. To mitigate this, banks may (1) offset timelier credit losses by lowering conservatism in other earnings components and (2) reduce credit losses by demanding greater borrower conservatism. We find that, under CECL, banks increase conservatism in loan losses but decrease conservatism in other earnings components, making overall conservatism only marginally increase. In sharp contrast, their borrowers increase conservatism by 40 percent, and borrowers’ increase is twice that of banks. This substantial spillover effect suggests that, by greatly increasing borrowers’ conservatism, CECL may strengthen debt governance of a broad scope of firms in the economy, thereby having economy-wide consequences beyond the banking industry and potentially enhancing the stability of the entire economy.
Data Availability: Data are publicly available from the sources identified in the study.
JEL Classifications: G21; M41; M48.
The Influence of Soil Physico-Mechanical Properties on Plant Growth and Subsoil Water Movement
Authors: Khelalfa Khaoula , Khelalfa Houssam 
Published: July 2024

Abstract
Within the cutting-edge realm of Geotechnical Biology, the interplay between soil mechanics and biological systems has unveiled profound insights that align with the rural sustainability, forestry and agroecosystems. This inquiry, encompassing the role of soil characteristics and parameters in shaping plant behavior and root growth, creating a suction effect that draws water towards them and underscores the intricate relationships that govern soil-plant interactions. A numerical simulation was expertly dissected using Plaxis 2D software, particularly focused on understanding the complex behavior of root water uptake over time and the changing level of groundwater and its dynamics rhythm affected by the evolution of plants. The output results in our study have important implications for understanding the soil-plant system and the role of geotechnical processes in biological analyses. Our findings suggest that the stability and behavior of geotechnical systems can have a significant impact on plant growth and distribution, underscoring the importance of considering geotechnical processes in biological analyses.
Developing skills for a healthy lifestyle by using interactive methods in teaching Biology and Health Education
Authors: Davidova Rositsa , Valcheva Irena 
Published: July 2024

Abstract
The aim of the article is to present the results of using interactive methods in the teaching of Biology and Health Education to 7th grade students for developing skills for a healthy lifestyle. The discussion is based on the topics: “The role of prokaryotic organisms in nature and their importance for man”, “The role of unicellular eukaryotic organisms in nature and their importance for man”, and “Talus plants. Seaweed”. The discussion is supported by fragments of lessons in which interactive methods are used – the method of associations through creating mind maps, discussion, case study, and role play. As a result of using of interactive methods, students develop key competencies for maintaining their own health and the health of society as a whole.
The debate - an opportunity for the formation of ecological culture in Biology and Health Education
Authors: Doichinova Klaida 
Published: July 2024

Abstract
The present study is part of a didactic experiment, which aims at establishing the application and effectiveness of the school debate, as an interactive method of teaching in Biology and Health Education in XII grade in order to form an environmental culture among students. The application of school debate as a part of interactive methods corresponding to the objectives of environmental education and upbringing of a selected methodological unit of the ‘Sustainable development - strategy for preserving life on Earth’ is presented, and options for its application in a specific stage of the macro structure of the lesson are proposed. The results of a questionnaire, conducted with students to explore their opinions on the application of the debate as a teaching method, are presented. The analysis of the results shows that students are motivated to actively engage in the process of learning Biology and Health Education, accept the debate as an interactive form of learning because they believe that it increases their environmental awareness and develops key skills such as, critical thinking; skills to support sustainable development; teamwork; making decisions on various environmental topics; improves the ability to analyze and evaluate the relationship between man-society-nature.
Cumulative ordinal quasi-symmetry model and its separation for square contingency tables with ordered categories
Authors: Ando Shuji , Yamamoto Kouji , Tomizawa Sadao 
Published: July 2024

Summary
This study deals with square contingency tables, which are two-way contingency tables in which the row and column variables consist of the same classification. When the categorical variables are grouped into ordered categories from quantitative variables by cut points, a score that approximates the distance between the midpoints of the quantitative scale categories may be used to reflect the characteristics of the data. As an asymmetry model based on scores, this study proposes the cumulative ordinal quasi-symmetry model and ordinal marginal homogeneity model based on cumulative probabilities. The asymmetric parameter in the proposed models would be useful for making inferences such as that a row variable is stochastically less than a column variable or vice versa. This study also gives a separation of the cumulative ordinal quasi-symmetry model, that is, the cumulative ordinal quasi-symmetry model holds if and only if both the cumulative quasi-symmetry and ordinal marginal homogeneity models hold. The usefulness of the proposed models and the proposed separation is demonstrated through real data analysis.