bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip
Authors: Shah Sonia , Guyatt Anna , Ladroue Christophe , Kumari Meena , Drenos Fotios , Shah Tina , Talmud Philippa J. , Casas Juan , Lowe Gordon , Rumley Ann , Lawlor Debbie A. , Kivimaki Mika , Whittaker John , Hingorani Aroon D. , Gaunt Tom R. , Zabaneh Delilah , Humphries Steve E. , Day Ian N. 
Published: August 2013

SummaryCoagulation phenotypes show strong intercorrelations, affect cardiovascular disease risk and are influenced by genetic variants. The objective of this study was to search for novel genetic variants influencing the following coagulation phenotypes: factor VII levels, fibrinogen levels, plasma viscosity and platelet count. We genotyped the British Women’s Heart and Health Study (n=3,445) and the Whitehall II study (n=5,059) using the Illumina HumanCVD BeadArray to investigate genetic associations and pleiotropy. In addition to previously reported associations (SH2B3, F7/F10, PROCR, GCKR, FGA/FGB/FGG, IL5), we identified novel associations at GRK5 (rs10128498, p = 1.30×10−6), GCKR (rs1260326, p = 1.63×10−6), ZNF259-APOA5 (rs651821, p = 7.17x10–6) with plasma viscosity; and at CSF1 (rs333948, p = 8.88×10−6) with platelet count. A pleiotropic effect was identified in GCKR which associated with factor VII (p = 2.16×10−7) and plasma viscosity (p = 1.63×10−6), and, to a lesser extent, ZNF259-APOA5 which also associated with factor VII and fibrinogen (p<1.00×10−2) and plasma viscosity (p<1.00×10−5). Triglyceride associated variants were overrepresented in factor VII and plasma viscosity associations. Adjusting for triglyceride levels resulted in attenuation of associations at the GCKR and ZNF259-APOA5 loci. In addition to confirming previously reported associations, we identified four single nucleotide polymorphisms (SNPs) associated with plasma viscosity and platelet count and found evidence of pleiotropic effects with SNPs in GCKR and ZNF259-APOA5. These triglyceride-associated, pleiotropic SNPs suggest a possible causal role for triglycerides in coagulation.
High-molecular-weight kininogen and the intrinsic coagulation pathway in patients with de novo acute myocardial infarction
Authors: Cubedo Judit , Ramaiola Ilaria , Padró Teresa , Martin-Yuste Victoria , Sabate-Tenas Manel , Badimon Lina 
Published: August 2013

SummaryAfter an acute ischaemic event serum proteins may change reflecting the ischaemic damage. Proteomic studies could provide new insights into potential biomarkers in the evolution of ischaemic syndromes. In this study we have investigated the coordinated changes in coagulation-related proteins in the evolution after an acute myocardial infarction (AMI). Serum proteome (2D-electrophoresis and MALDI-TOF/ TOF) of AMI-patients within the first 6 hours after event onset (admission-time) and 3 days after were compared to controls. Systems biology and bioinformatic analysis were performed to identify the differentially expressed canonical pathways. In silico analysis of differential proteins revealed changes in the intrinsic coagulation pathway in the early phase post-AMI. The two identified high-molecular weight kininogen (HMWK) clusters were inversely correlated in AMI patients at admission, being the intensity of the low-molecular-weight form inversely related to myocardial necrosis (p<0.05). Factor XI (FXI) levels were decreased in AMI patients at admission and normalised 3 days after (p<0.05). There was an early increase in fibrinogen gamma and D-dimer at admission, followed by a decrease in fibrinogen turnover 3 days after (p<0.05). The influence of elapsed time of ischaemia on fibrinogen distribution changes was validated in coronary thrombi retrieved by thromboaspiration. In conclusion, our results demonstrate an active exchange between HMWK forms and a decrease in FXI indicative of intrinsic pathway activation, together with an increase in fibrinogen gamma turnover and D-dimer formation in the early phase post-AMI. Moreover, coronary thrombi showed a dynamic evolution in fibrinogen composition depending on the duration of ischaemia influencing serum fibrinogen-related products content.
Carotid Plaque MRI and Stroke Risk
Authors: Gupta Ajay , Baradaran Hediyeh , Schweitzer Andrew D. , Kamel Hooman , Pandya Ankur , Delgado Diana , Dunning Allison , Mushlin Alvin I. , Sanelli Pina C. 
Published: August 2013

Background and Purpose—
MRI characterization of carotid plaque has been studied recently as a potential tool to predict stroke caused by carotid atherosclerosis. We performed a systematic review and meta-analysis to summarize the association of MRI-determined intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap with subsequent ischemic events.

Methods—
We performed a comprehensive literature search evaluating the association of carotid plaque composition on MRI with ischemic outcomes. We included cohort studies examining intraplaque hemorrhage, lipid-rich necrotic core, or thinning/rupture of the fibrous cap with mean follow-up of ≥1 month and an outcome measure of ipsilateral stroke or transient ischemic attack. A meta-analysis using a random-effects model with assessment of study heterogeneity and publication bias was performed.

Results—
Of the 3436 articles screened, 9 studies with a total of 779 subjects met eligibility for systematic review. The hazard ratios for intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap as predictors of subsequent stroke/transient ischemic attack were 4.59 (95% confidence interval, 2.91–7.24), 3.00 (95% confidence interval, 1.51–5.95), and 5.93 (95% confidence interval, 2.65–13.20), respectively. No statistically significant heterogeneity or publication bias was present in the 3 main meta-analyses performed.

Conclusions—
The presence of intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap on MRI of carotid plaque is associated with increased risk of future stroke or transient ischemic attack in patients with carotid atherosclerotic disease. Dedicated MRI of plaque composition offers stroke risk information beyond measurement of luminal stenosis in carotid atherosclerotic disease.
Occupational Noise Exposure and the Risk of Stroke
Authors: Stokholm Zara A. , Bonde Jens Peter , Christensen Kent L. , Hansen Åse M. , Kolstad Henrik A. 
Published: August 2013

Background and Purpose—
Traffic noise <60 dB(A) has been associated with an increased risk of stroke. We investigated this relationship for 80 to 86 dB(A) occupational noise.

Methods—
We followed 116 568 industrial and 47 679 financial workers by linkage to Danish registries 2001 through 2007. Full-shift noise levels were estimated from subsets of workers at baseline and end of follow-up.

Results—
We identified 981 stroke patients and observed a 27% increased confounder-adjusted risk of stroke for industrial compared with financial workers. However, longer duration or higher noise level within the industrial workers were unrelated to the risk of stroke.

Conclusions—
Our study did not support an association between occupational noise exposure and stroke, and the higher risk among industrial workers may reflect lifestyle differences.
The Conversion of Ruth in Targum Ruth
Authors: Brady Christian M. M. 
Published: August 2013

Abstract
In the book of Ruth there is no doubt that the title character is a central figure. Targum Ruth re-presents her as the Rabbinic proselyte par excellence. This is accomplished primarily through additions to 1:16–7. But Ruth’s status as the ideal convert is also confirmed thorough Boaz’s announcement that she would be “saved from the judgment of Gehenna so that [her] portion may be with Sarah and Rebekah and Rachel and Leah” (TgRuth 2:12) and that she is “a righteous woman and there is in [her] strength to bear the yoke of the commandments of the LORD” (TgRuth 3:11). Examining these and other changes to the biblical text introduced by the Targumist, this article demonstrates how, in the Targum, Ruth becomes not just an admirable woman who acts out of kindness to her mother-in-law but is truly the Rabbinic exemplar for all converts.
inTB - a data integration platform for molecular and clinical epidemiological analysis of tuberculosis
Authors: Soares Patrícia , Alves Renato J , Abecasis Ana B , Penha-Gonçalves Carlos , Gomes M Gabriela M , Pereira-Leal José B 
Published: August 2013

Abstract

Background
Tuberculosis is currently the second highest cause of death from infectious diseases worldwide. The emergence of multi and extensive drug resistance is threatening to make tuberculosis incurable. There is growing evidence that the genetic diversity of Mycobacterium tuberculosis may have important clinical consequences. Therefore, combining genetic, clinical and socio-demographic data is critical to understand the epidemiology of this infectious disease, and how virulence and other phenotypic traits evolve over time. This requires dedicated bioinformatics platforms, capable of integrating and enabling analyses of this heterogeneous data.

Results
We developed inTB, a web-based system for integrated warehousing and analysis of clinical, socio-demographic and molecular data for Mycobacterium sp. isolates. As a database it can organize and display data from any of the standard genotyping methods (SNP, MIRU-VNTR, RFLP and spoligotype), as well as an extensive array of clinical and socio-demographic variables that are used in multiple countries to characterize the disease. Through the inTB interface it is possible to insert and download data, browse the database and search specific parameters. New isolates are automatically classified into strains according to an internal reference, and data uploaded or typed in is checked for internal consistency. As an analysis framework, the system provides simple, point and click analysis tools that allow multiple types of data plotting, as well as simple ways to download data for external analysis. Individual trees for each genotyping method are available, as well as a super tree combining all of them. The integrative nature of inTB grants the user the ability to generate trees for filtered subsets of data crossing molecular and clinical/socio-demografic information. inTB is built on open source software, can be easily installed locally and easily adapted to other diseases. Its design allows for use by research laboratories, hospitals or public health authorities. The full source code as well as ready to use packages is available at http://www.evocell.org/inTB.

Conclusions
To the best of our knowledge, this is the only system capable of integrating different types of molecular data with clinical and socio-demographic data, empowering researchers and clinicians with easy to use analysis tools that were not possible before.
Debate on HES safety is important, but must be based on facts
Authors: Haase Nicolai , Müller Rasmus , Perner Anders 
Published: August 2013

Abstract
The Scandinavian Starch for Severe Sepsis / Septic Shock (6S) trial showed that hydroxyethyl starch was harmful compared to Ringer’s acetate in patients with severe sepsis when used according to clinical practice and in alignment with the recommendations by the manufactures and authorities. The different interpretation by Chapell and Jacob’s rely on misreading of the trial publication and is not supported by the trial data. Several hypotheses may be made regarding less harmful ways of using HES in critically ill patients, but clinicians, guideline committee members and authorities need to acknowledge that such safer ways have not yet been identified.
Interpenetrating Polymer Network Using Amphiphilic Poly(N-vinylacetamide) and Poly(2-hydroxyethyl methacrylate) to Deactivate Phosphate Ester Compounds
Authors: Ajiro Hiroharu , Akashi Mitsuru 
Published: August 2013

Abstract
An interpenetrating polymer network (IPN) of poly(N-vinylacetamide) (PNVA) and poly(2-hydroxylethyl methacrylate) (HEMA) was designed to deactivate agricultural chemicals. The imprinting effect of PNVA hydrogel preparation is discussed, as compared to PNVA single hydrogels and nonimprinted IPNs in the methamidophos adsorption experiments.
Can foot compression under a plaster cast prevent deep-vein thrombosis during lower limb immobilisation?
Authors: Domeij-Arverud E. , Latifi A. , Labruto F. , Nilsson G. , Ackermann P. W. 
Published: August 2013

We hypothesised that adjuvant intermittent pneumatic compression (IPC) beneath a plaster cast would reduce the risk of deep-vein thrombosis (DVT) during post-operative immobilisation of the lower limb. Of 87 patients with acute tendo Achillis (TA) rupture, 26 were prospectively randomised post-operatively after open TA repair. The treatment group (n = 14) received two weeks of IPC of the foot for at least six hours daily under a plaster cast. The control group (n = 12) had no additional treatment. At two weeks post-operatively all patients received an orthosis until follow-up at six weeks. At two and six weeks the incidence of DVT was assessed using colour duplex sonography by two ultrasonographers blinded to the treatment. Two patients withdrew from the study due to inability to tolerate IPC treatment. An interim analysis demonstrated a high incidence of DVT in both the IPC group (9 of 12, 75%) and the controls (6 of 12, 50%) (p = 0.18). No significant differences in incidence were detected at two (p = 0.33) or six weeks (p = 0.08) post-operatively. Malfunction of the IPC leading to a second plaster cast was found to correlate with an increased DVT risk at two weeks (φ = 0.71; p = 0.019), leading to a premature abandonment of the study. We cannot recommend adjuvant treatment with foot IPC under a plaster cast for outpatient DVT prevention during post-operative immobilisation, owing to a high incidence of DVT related to malfunctioning of this type of IPC application. Cite this article: Bone Joint J 2013;95-B:1227–31.
‘It’s very difficult to enable choice’: Citizenship education for welfare professionals in challenging times
Authors: Gifford Chris , McGlynn Catherine 
Published: August 2013

Abstract
This article examines how the themes employed in citizenship teaching and learning are relevant to understanding the education of welfare professionals in English universities. The academic literature on citizenship education has predominantly focused upon the school curriculum and, consequently, the experiences of children and young people. Nevertheless, the boundaries of citizenship education are contested and the research presented here concerns its applicability to vocational programmes in Higher Education outside of teacher training. We argue that although citizenship education has become more explicit within secondary school classrooms, educators involved in the teaching and training of welfare professionals find themselves caught within a number of dynamics that make it difficult for them to engage directly with the potential value, as well as the pitfalls, of extending a programme of formal citizenship education to their students. Taking a phenomenongraphic approach, we explore how these educators understand citizenship and negotiate the idea of citizenship education within the university context and the wider community within which their students are being trained to practice. In so doing, the limitations and possibilities of extending citizenship teaching and learning to new constituencies are highlighted.
Reviews
Authors: Tse Thomas , Jerome Lee , Davies Ian , Clemitshaw Gary 
Published: August 2013

Abstract
Reshaping Education for Citizenship: Democratic National Citizenship in Hong Kong, Pak-Sang Lai and Michael Byram (2012) Newcastle upon Tyne: Cambridge Scholars Publishing, 257 pp., ISBN: 978-1-4438-3531-2, h/bk, £39.99
The Labour Party and Citizenship Education: Policy Networks and the Introduction of Citizenship Lessons in Schools, Ben Kisby (2012) Manchester: Manchester University Press, 208pp., ISBN: 978-0-7190-8622-9, h/bk, £65.00
The Righteous Mind: Why Good People are Divided by Politics and Religion, Jonathan Haidt (2012) London: Allen Lane, XVII + 419pp., ISBN: 978-1-846-14181-2, h/bk, £20.00
Pass the New Life in the UK Test: The Complete Study Guide for 2013, Celine Castelino (2013) Leicester: National Institute of Adult Continuing Education, 333 pp., ISBN: 978-1-86201-702-3, p/bk, £11.95
Worth a closer look: A comparative study of Xala and Osuofia in London
Authors: Kilian Cassis 
Published: August 2013

Abstract
Since the turn of the twenty-first century, films produced in Africa have been categorized as either ‘elitist’ auteur cinema or ‘popular’ video films. This antagonism is not least due to a tendency to overload the study of African film with theory and thereby to lose sight of the movies themselves. As the same concepts and authors are cited repeatedly, we read a lot of self-references instead of references to the films themselves. In an attempt to bridge the emerging gap between these two types of film, the article proposes a closer look at Ousmane Sembène’s satire Xala from 1974 and the successful two-part video comedy Osuofia in London by Kingsley Ogoro from 2003/2004. The films have little in common in terms of production and reception contexts, but a comparison of the auteur film and the video film may reveal similarities in theme and mise-en-scène.
‘Army of Cars’: The automobile in Flora Gomes’ The Blue Eyes of Yonta
Authors: Teversham Edward 
Published: August 2013

Abstract
This article explores Flora Gomes’ use of the automobile as a visual trope in his seminal film The Blue Eyes of Yonta (1991). It is argued that the automobile is an essential component in the meaning and structure of the film. This ‘automobility’ is compared to the high levels of pedestrianism in Gomes’ other work, as well as the role that the automobile has played within recent Guinean history. By considering the car both as a functional presence in the film as well as a more figurative object, it is observed that the automobile inhabits various spaces in The Blue Eyes of Yonta: social, cultural and political. The result is that Gomes uses the car as a multifaceted metaphor that encourages the viewer to reconsider how we incorporate the modern into our everyday behaviour.
(Auto)Biographical and cinematographic exposition of Dambudzo Marechera on documentary film and video
Authors: Mhiripiri Nhamo Anthony 
Published: August 2013

Abstract
Documentary film is a technical artistic method whose importance in the representation of Dambudzo Marechera1 – probably Zimbabwe’s best-known creative writer – has not been adequately investigated. Marechera is documented in sequences of The House of Hunger (Chris Austin, 1983), Olley Maruma’s After the Hunger and Drought (1985) and in untitled footage shot by Edwina Spicer (1984). These documentaries have cinematographic significance, but they also challenge and reproduce popular impressions of Marechera as an eccentric crazy writer. Besides communicating pro-filmic visuals of Marechera himself, the documentaries offer extensive oral presentations by Marechera on a broad range of topics, including his sanity or insanity and his notions on censorship, identity and his writing habits and plans. This article will outline the structure of each individual documentary, and the relationships between Marechera and the films’ directors will be explored.
Buprenorphine in the treatment of non-suicidal self-injury: a case series and discussion of the literature
Authors: Norelli Lisa J. , Smith Howard S. , Sher Leo , Blackwood Tracey A. 
Published: August 2013

Abstract
A global public health problem, non-suicidal self-injury (NSSI) is highly prevalent in both males and females, and tends to first occur in adolescence. NSSI is correlated with a history of childhood trauma, and with a variety of developmental and psychiatric disorders. NSSI is associated with increased risk of morbidity and premature death from suicide, accidents, and natural causes. Current treatment approaches are inadequate for a substantial number of people. Converging evidence for opioid system dysregulation in individuals with NSSI make this a promising area of investigation for more effective treatments. The pharmacological profile of buprenorphine, a potent μ-opioid partial agonist and κ-opioid antagonist, suggests that it may be beneficial. In this paper, we describe the successful treatment of severe NSSI with buprenorphine in six individuals, followed by discussion and further recommendations.
Increasing Africa’s Share of Vertical Investments through Single Window Systems
Authors: Ndonga Dennis 
Published: August 2013

AbstractThe growth of international trade in recent years has highlighted the importance of customs authorities as the gateway to the global market. However, border delays and inefficiencies resulting from cumbersome documentation requirements have disrupted the flow of goods and acted as a non-tariff barrier to international trade in many African countries. Additionally, these same deficiencies have interrupted the inward flow of vertical Foreign Direct Investment (FDI). When searching for suitable locations to establish manufacturing plants, foreign investors place emphasis on a number of factors such as the cost of exporting, expediency of importing time sensitive production inputs and distance to target markets. Customs efficiency plays a major role in positively influencing these factors and hence forms a crucial part of any investment decision. This article examines the negative impact of inefficient border procedures on vertical FDI inflows to Africa. The article recommends the implementation of single window systems as an investment facilitation tool.
Methimazole-induced myositis: a case report and review of the literature
Authors: Bou Khalil R , Abou Salbi M , Sissi S , El Kara N , Azar E , Khoury M , Abdallah G , Hreiki J , Farhat S 
Published: August 2013

SummaryMethimazole is an anti-thyroid drug commonly used to treat hyperthyroidism and is a relatively safe medication. Several side effects have been reported and usually develop within 3 months of therapy. Well-known adverse reactions include agranulocytosis, hepatitis, skin eruptions, and musculoskeletal complaints such as myalgia, arthralgia, and arthritis. So far, myositis secondary to carbimazole was described in the context of a lupus-like syndrome or other rare cases of anti-neutrophil cytoplasmic antibodies-associated vasculitis. Methimazole-induced myositis occurring independently of such reactions was rarely stated. We report a patient with hyperthyroidism who, early after therapy with methimazole, developed hepatitis, eosinophilia, and fever that resolved completely after stopping the medication as well as a delayed onset of biopsy-proven eosinophilic myositis and fasciitis of gluteal muscles that resolved eventually without any additional therapy. Therefore, we raise the awareness regarding a rare side effect of methimazole: myositis.Learning pointsSeveral differential diagnoses arise when managing a hyperthyroid patient with muscle complaints.Both hyperthyroidism and methimazole are associated with myositis.Methimazole-induced myositis is a rare clinical entity.Resolution of symptoms may occur after stopping methimazole.