bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semi‐continuous in situ magnetic separation for enhanced extracellular protease production—modeling and experimental validation
Authors: Cerff Martin , Scholz Alexander , Käppler Tobias , Ottow Kim E. , Hobley Tim J. , Posten Clemens 
Published: March 2013

AbstractIn modern biotechnology proteases play a major role as detergent ingredients. Especially the production of extracellular protease by Bacillus species facilitates downstream processing because the protease can be directly harvested from the biosuspension. In situ magnetic separation (ISMS) constitutes an excellent adsorptive method for efficient extracellular protease removal during cultivation. In this work, the impact of semi‐continuous ISMS on the overall protease yield has been investigated. Results reveal significant removal of the protease from Bacillus licheniformis cultivations. Bacitracin‐functionalized magnetic particles were successfully applied, regenerated and reused up to 30 times. Immediate reproduction of the protease after ISMS proved the biocompatibility of this integrated approach. Six subsequent ISMS steps significantly increased the overall protease yield up to 98% because proteolytic degradation and potential inhibition of the protease in the medium could be minimized. Furthermore, integration of semi‐continuous ISMS increased the overall process efficiency due to reduction of the medium consumption. Process simulation revealed a deeper insight into protease production, and was used to optimize ISMS steps to obtain the maximum overall protease yield. Biotechnol. Bioeng. 2013; 110: 2161–2172. © 2013 Wiley Periodicals, Inc.
Candida bombicola as a platform organism for the production of tailor‐made biomolecules
Authors: Roelants Sophie L.K.W. , Saerens Karen M.J. , Derycke Thibaut , Li Bing , Lin Yao‐Cheng , Van de Peer Yves , De Maeseneire Sofie L. , Van Bogaert Inge N.A. , Soetaert Wim 
Published: March 2013

AbstractThe yeast Candida bombicola is capable of producing high amounts (400 g/L) of the biosurfactant sophorolipids. The genetic makeup of this industrially important yeast has recently been uncovered and molecular manipulation techniques have been developed. Hence, all tools for the development of new bioprocesses with C. bombicola are now available. As a proof of concept, the production of two totally different molecules was aimed for: the bioplastic polyhydroxyalkanoate (PHA) and a new‐to‐nature cellobioselipid‐biosurfactant. Integration of the new functionalities at genomic loci necessary for sophorolipid production safeguards the new biomolecules from sophorolipid contamination, while taking advantage of the regulation of the sophorolipid gene cluster. A maximum yield of 2.0% wt/dwt PHA was obtained; furthermore, this is the first time cellobioselipid synthesis by a non‐natural producer is reported. We here provided proof of concept that C. bombicola can be transformed into a platform organism for the production of tailor‐made biomolecules. Biotechnol. Bioeng. 2013; 110:2494–2503. © 2013 Wiley Periodicals, Inc.
Long‐term results of primary stenting for subclavian artery disease
Authors: Higashimori Akihiro , Morioka Nobuyuki , Shiotani Shinnji , Fujihara Masahiko , Fukuda Keisuke , Yokoi Yoshiaki 
Published: March 2013

ObjectivesTo evaluate initial and long‐term results of endovascular therapy (EVT) for symptomatic subclavian artery (SCA) disease. Background: EVT for SCA disease has a similar success rate as open surgery, but the long‐term patency of EVT alone is uncertain.MethodsWe retrospectively studied 59 consecutive patients (42 males and 17 females) with 60 lesions. Mean patient age was 68 ± 10 years. Clinical symptoms were vertebrobasilar insufficiency in 21 patients (35.0%), arm claudication in 20 patients (33.3%), angina pectoris in 12 patients (20%), severe arm ischemia in 3 patients (5.0%), vascular access insufficiency in 3 patients (5.0%), and leg ischemia in 1 patient (1.7%). A total of 57 stents were implanted. All patients were followed up at 1, 3, 6, and 12 months after the procedure and annually thereafter.ResultsThe technical success rate was 93.3%. All patients for whom technical success was obtained received stents. There were four technical failures, all of which were owing to the failure of crossing the wire in occluded lesions. There were no procedure‐related deaths. There were two stroke events (3.4%) and one embolic event (1.7%). Primary patency rates were 94.9, 90.8, and 85.8% at 1, 3, and 5 years, respectively.ConclusionsEVT for SCA disease is an effective treatment with regard to initial success rate, clinical efficacy, and long‐term primary patency. This minimally invasive procedure is appropriate as the treatment of first choice for proximal subclavian arterial obstructive disease. © 2013 Wiley Periodicals, Inc.
ChemInform Abstract: Synthesis of [(SnSe)1.15]m(TaSe2)n Ferecrystals: Structurally Tunable Metallic Compounds.
Authors: Atkins Ryan , Wilson Jason , Zschack Paul , Grosse Corinna , Neumann Wolfgang , Johnson David C. 
Published: March 2013

AbstractThe title ferecrystals (fere: Latin, almost) with 1 ≤ n,m ≤ 6 and n and m varied independently are prepared by physical vapor deposition of the elements followed by annealing at 400 °C for 30 min.
ChemInform Abstract: Crystal Structure of FePb4Sb6Se14 and Its Structural Relationship with FePb3Sb4Se10.
Authors: Poudeu Pierre F. P. , Djieutedjeu Honore , Sahoo Pranati 
Published: March 2013

AbstractSingle crystals of FePb4Sb6Se14 are prepared by solid state reaction of the elements (silica tube, 873 K, 72 h).
ChemInform Abstract: Fine Hierarchy of the V—O Bonds by Advanced Solid State NMR: Novel Pb4(VO2)(PO4)3 Structure as a Textbook Case.
Authors: Tricot Gregory , Mentre Olivier , Cristol Sylvain , Delevoye Laurent 
Published: March 2013

AbstractThe new title compound is prepared by reaction of a stoichiometric mixture of PbO, V2O5, and (NH4)2HPO4 (alumina crucible, 700 °C, 48 h).
ChemInform Abstract: Direct Synthesis of Bimetallic Pd3Ag Nanoalloys from Bulk Pd3Ag Alloy.
Authors: Xu Tao , et al. et al. 
Published: March 2013

AbstractPd3Ag nanoparticles are prepared by dispersion of bulk Pd3Ag in liquid Li (Ni crucible, 250 °C, 4 h).
ChemInform Abstract: Three Organically Templated Magnesium Sulfates: Chemical Preparation, Hydrogen‐Bonded Structures and Thermal Behavior.
Authors: Rekik Walid , Naili Houcine , Mhiri Tahar , Bataille Thierry 
Published: March 2013

AbstractThe crystal structures of the new compounds (II), (III), and (IV) are determined by single crystal XRD.
ChemInform Abstract: Molecular Polyselenide Anions Sandwiched Between Cationic Extended Metal Hydroxides: Synthesis and Structures of [Sr2Sn(OH)6(H2O)6]Se4 and [Sr2Sn(OH)6(H2O)5] Se3·H2O.
Authors: Wang Xiqu , Wang Haiyin H. , Makarenko Boris , Jacobson Allan J. 
Published: March 2013

AbstractThe new compound [Sr2Sn(OH)6(H2O)6]Se4 (I) is synthesized by hydrothermal reaction of Sn, Se, Sr(OH)2, and LiOH·H2O in water (autoclave, 220 °C, 2 d; 40% yield).
ChemInform Abstract: Multinary Selenides with Unusual Coordination Environment of Bismuth.
Authors: Chung Ming‐Yan , Lee Chi‐Shen 
Published: March 2013

AbstractThe new compounds Sr8.007Ge2.043Bi7.949Se24 (I), Sr8YGe2Bi7Se24 (II), Sr3Sn0.96Bi2.04Se8 (III), Ba3SnSb2Se8 (IV), and Ba3.00Sn0.87Bi2.13Se8 (V) are prepared by solid state reaction of stoichiometric mixtures of the elements (1023 K, 1 d).
ChemInform Abstract: Sr2Mn2O4Se: A New Oxychalcogenide with Antiferromagnetic Chains.
Authors: Free David G. , Herkelrath Sebastian J. C. , Clarke Simon J. 
Published: March 2013

AbstractThe title compound is synthesized from mixtures of SrO, Mn, MnO2, Se, and KCl as a flux (alumina crucible, 800 °C, 7 d).
ChemInform Abstract: (NH4)AgMoS4: Synthesis, Structure and Catalytic Activity.
Authors: Shafaei‐Fallah Maryam , Malliakas Christos D. , Kanatzidis Mercouri G. 
Published: March 2013

AbstractThe title compound is precipitated from an aqueous solution of (NH4)2MoS4 and AgNO3 (room temperature, 1 h, 70% yield).
ChemInform Abstract: Toward Efficient Asymmetric Carbon—Carbon Bond Formation: Continuous Flow with Chiral Heterogeneous Catalysts.
Authors: Tsubogo Tetsu , Yamashita Yasuhiro , Kobayashi Shu 
Published: March 2013

AbstractA polymer‐supported Pybox catalyst is successfully used in the continuous flow system and works well for 8.5 days without loss of activity.
ChemInform Abstract: Syn‐Selective Kobayashi Aldol Reaction Using the E,E‐Vinylketene Silyl N,O‐Acetal.
Authors: Mukaeda Yuki , Kato Takuya , Hosokawa Seijiro 
Published: March 2013

AbstractIn the presence of excess of TiCl4, the acetal (I) undergoes syn‐selective aldol reaction.
ChemInform Abstract: Application of SO3H Silica Gel to Deprotection of Silyl Ethers.
Authors: Fujii Hideaki , Yamada Takaaki , Hayashida Kohei , Kuwada Miki , Hamasaki Atom , Nobuhara Kazunori , Ozeki Sumio , Nagase Hiroshi 
Published: March 2013

AbstractO—Si bonds in various alkyl and aryl silyl ethers are efficiently cleaved by a new SO3H silica gel on which alkylsulfonic acid group are immobilized.
ChemInform Abstract: Decarboxylative Allylation of Trifluoroethyl Sulfones and Approach to Difluoromethyl Compounds.
Authors: Shibata Norio , Fukushi Kazunobu , Furukawa Tatsuya , Suzuki Satoru , Tokunaga Etsuko , Cahard Dominique 
Published: March 2013

AbstractPd‐catalyzed coupling of trifluoroethyl sulfones with allyl carbonates allows an efficient access to fluorinated homoallyl sulfones like (III), (V), (VI), and (XI).
ChemInform Abstract: Fluorinated β‐Nitro Amines by a Selective ZrCl4‐Catalyzed Aza‐Henry Reaction of (E)‐Trifluoromethyl Aldimines.
Authors: Fioravanti Stefania , Pellacani Lucio , Vergari Maria Cecilia 
Published: March 2013

AbstractThe stereochemical outcome seems to be unaffected by the CF3 group as well as of the alkyl chain of the nitro compound (II).
ChemInform Abstract: Enantioselective Synthesis of β‐Aryloxycarboxylic Esters via Asymmetric Hydrogenation of β‐Aryloxy‐α,β‐unsaturated Esters.
Authors: Stewart Gavin W. , Shevlin Michael , Yamagata Adam D. Gammack , Gibson Andrew W. , Keen Stephen P. , Scott Jeremy P. 
Published: March 2013

AbstractWalphos W008‐1 promotes the hydrogenation of unsaturated esters of type (E)‐(III) and their (Z)‐isomers.
ChemInform Abstract: Efficient Assembly of Iminodicarboxamides by a “Truly” Four‐Component Reaction.
Authors: Khoury Kareem , Sinha Mantosh K. , Nagashima Tadamichi , Herdtweck Eberhardt , Doemling Alexander 
Published: March 2013

AbstractUnder optimized conditions, the method provides iminodicarboxamides in low to moderate yields.
ChemInform Abstract: Regio‐ and Enantioselective Cobalt‐Catalyzed Reductive [3 + 2] Cycloaddition Reaction of Alkynes with Cyclic Enones: A Route to Bicyclic Tertiary Alcohols.
Authors: Wei Chu‐Hung , Mannathan Subramaniyan , Cheng Chien‐Hong 
Published: March 2013

AbstractThe bridged alcohol systems are synthesized by reductive [3 + 2] cycloaddition of cyclic enones with alkynes in the presence of Co salts.
ChemInform Abstract: In situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes Using a Continuous Flow Method.
Authors: Cantillo David , Baghbanzadeh Mostafa , Kappe C. Oliver 
Published: March 2013

AbstractThe safe and scalable process allows the selective reduction of various functionalized nitroarenes to the corresponding anilines.
ChemInform Abstract: A Catalyst‐Free C—H Hydroarylation of Coumarin‐Derived ortho‐Quinone Methide (o‐QM) with Electron‐Rich Arenes in Glycerol.
Authors: Kumar Atul , Kumar Mukesh , Gupta Maneesh Kumar , Gupta Lalit Prakash 
Published: March 2013

AbstractThe methide obtained from the carbonyl‐containing substrates with aromatic or aliphatic aldehydes is further treated with tertiary aromatic amines to produce the different types of products shown.
ChemInform Abstract: Platinum‐Catalyzed Oxoarylations of Ynamides with Nitrones.
Authors: Bhunia Sabyasachi , Chang Chin‐Jung , Liu Rai‐Shung 
Published: March 2013

AbstractReaction of nitrones (I) with the ynamides (II), (IVa), and (IVc) provides a new approach to amides of type (III)/ (V).
ChemInform Abstract: Retropinacol/Cross‐Pinacol Coupling Reactions — A Catalytic Access to 1,2‐Unsymmetrical Diols.
Authors: Scheffler Ulf , Stoesser Reinhard , Mahrwald Rainer 
Published: March 2013

AbstractThe reaction yields unsymmetrical cross‐pinacol products (III) and (V).
ChemInform Abstract: Knoevenagel Condensations of 1,3‐Dicarbonyl Compounds with Aldehydes Catalyzed by Heterogeneous PS‐AlCl3 Without Solvents.
Authors: Zhang Yi , Dou Qianqian , Dai Liyan , Wang Xiaozhong , Chen Yingqi 
Published: March 2013

AbstractThe catalyst is applicable to a wide range of aldehydes and can be reused several times without loss of activity.
ChemInform Abstract: A New Synthesis of N‐Substituted o‐Trifluoroacetylanilines.
Authors: Shidlovskii Alexander F. , Golubev Alexander S. , Gusev Dmitrii V. , Suponitsky Kyrill Yu. , Peregudov Alexander S. , Chkanikov Nikolai D. 
Published: March 2013

AbstractA convenient access to N‐alkyl‐ (III) and N‐aryl (V) o‐trifluoroacetylanilines via reaction of corresponding N‐substituted isatoic anhydrides with Ruppert—Prakash reagent (II) is described.
ChemInform Abstract: Direct, Redox‐Neutral Prenylation and Geranylation of Secondary Carbinol C—H Bonds: C4‐Regioselectivity in Ruthenium‐Catalyzed C—C Couplings of Dienes to α‐Hydroxy Esters.
Authors: Leung Joyce C. , Geary Laina M. , Chen Te‐Yu , Zbieg Jason R. , Krische Michael J. 
Published: March 2013

AbstractThis allows for the direct conversion of secondary to tertiary alcohols and provides the first examples for C4‐regioselectivity in catalytic C—C coupling reactions of carbonyl derivatives with 2‐substituted dienes.
ChemInform Abstract: A Nonmetal Approach to α‐Heterofunctionalized Carbonyl Derivatives by Formal Reductive X—H Insertion.
Authors: Miller Eric J. , Zhao Wei , Herr Jonathan D. , Radosevich Alexander T. 
Published: March 2013

AbstractThe reductive coupling of α‐keto esters with protic oxygen and nitrogen nucleophiles, mediated by P(NMe2)3, allows the synthesis of α‐heterofunctionalized esters including an asymmetric version [cf.
ChemInform Abstract: β‐Aryl Nitrile Construction via Palladium‐Catalyzed Decarboxylative Benzylation of α‐Cyano Aliphatic Carboxylate Salts.
Authors: Shang Rui , Huang Zheng , Xiao Xiao , Lu Xi , Fu Yao , Liu Lei 
Published: March 2013

AbstractThe first example of intermolecular decarboxylative benzylation of activated aliphatic carboxylate salts is presented.
ChemInform Abstract: Enantioselective Aza‐Morita—Baylis—Hillman Reactions of Acrylonitrile Catalyzed by Palladium(II) Pincer Complexes Having C2‐Symmetric Chiral Bis(imidazoline) Ligands.
Authors: Hyodo Kengo , Nakamura Shuichi , Shibata Norio 
Published: March 2013

AbstractVarious α‐methylene‐β‐aminonitriles of type (III) can be readily obtained with high levels of enantioselectivity in the presence of complex (Ia).
ChemInform Abstract: A Facile Preparation of Palladium Nanoparticles Supported on Magnetite/s‐Graphene and Their Catalytic Application in Suzuki—Miyaura Reaction.
Authors: Hu Jiefeng , Wang Yuping , Han Min , Zhou Yaoming , Jiang Xiaoqing , Sun Peipei 
Published: March 2013

AbstractA series of biphenyls is readily available within a short time.
ChemInform Abstract: New Synthesis of Dibenzofulvenes by Palladium‐Catalyzed Double Cross‐Coupling Reactions.
Authors: Shimizu Masaki , Nagao Ikuhiro , Kiyomoto Shin‐ichi , Hiyama Tamejiro 
Published: March 2013

AbstractTwo new synthetic methods for the synthesis of dibenzofulvenes are presented.
ChemInform Abstract: Organocatalytic Asymmetric Epoxidation and Tandem Epoxidation/Passerini Reaction under Eco‐Friendly Reaction Conditions.
Authors: Deobald Anna Maria , Correa Arlene G. , Rivera Daniel G. , Paixao Marcio Weber 
Published: March 2013

AbstractDiarylprolinol silyl ethers are used as organocatalysts in asymmetric epoxidation reactions of α,β‐unsaturated aldehydes affording optically active epoxides (II) in high yields.
ChemInform Abstract: CO2‐Activation for γ‐Butyrolactones and Its Application in the Total Synthesis of (.+‐.)‐Heteroplexisolide E.
Authors: Li Suhua , Ma Shengming 
Published: March 2013

AbstractAn efficient Ni(0)‐catalyzed highly regio‐ and stereoselective hydrocarboxylation of homopropargylic alcohols is used for the preparation of a variety of γ‐butyrolactones, including the natural compound (.+‐.)‐heteroplexisolide E (XII).
ChemInform Abstract: Facile Aerobic Photooxidative Oxylactonization of Oxocarboxylic Acids in Fluorous Solvents.
Authors: Tada Norihiro , Cui Lei , Ishigami Takafumi , Ban Kazunori , Miura Tsuyoshi , Uno Bunji , Itoh Akichika 
Published: March 2013

AbstractThe photooxidative oxylactonization of 4‐acylbutyric acids proceeds readily in perfluorohexane in the presence of TFAA as a promoter.
ChemInform Abstract: Tin Tetrachloride‐Catalyzed Regiospecific Allylic Substitution of Quinone Monoketals: An Easy Entry to Benzofurans and Coumestans.
Authors: Liu Yingjie , Liu Jingxin , Wang Mang , Liu Jun , Liu Qun 
Published: March 2013

AbstractThis reaction is a formal [3+2] cycloaddition under mild conditions yielding substituted benzofurans (III) and coumestans (VI).
ChemInform Abstract: Highly Enantioselective Addition of Enals to Isatin‐Derived Ketimines Catalyzed by N‐Heterocyclic Carbenes. Synthesis of Spirocyclic γ‐Lactams.
Authors: Lv Hui , Tiwari Bhoopendra , Mo Junming , Xing Chong , Chi Yonggui Robin 
Published: March 2013

AbstractThe triazolium salt NHC efficiently promotes the process to afford the spirocyclic heterocyclic scaffolds with moderate to good diastereoselectivity and generally high enantioselectivity.
ChemInform Abstract: A General Approach to Substituted Benzimidazoles and Benzoxazoles via Heterogeneous Palladium‐Catalyzed Hydrogen‐Transfer with Primary Amines.
Authors: Pizzetti Marianna , De Luca Elisa , Petricci Elena , Porcheddu Andrea , Taddei Maurizio 
Published: March 2013

AbstractThe reaction of o‐phenylenediamine or N‐monoalkylphenylenediamines with a variety of primary amines leads to formation of 2‐substituted or 1,2‐disubstituted benzimidazoles.
ChemInform Abstract: Synthesis and Temperature‐Induced Morphological Control in a Hybrid Porous Iron—Phosphonate Nanomaterial and Its Excellent Catalytic Activity in the Synthesis of Benzimidazoles.
Authors: Dutta Arghya , Mondal John , Patra Astam K. , Bhaumik Asim 
Published: March 2013

AbstractThe catalyst can be recycled and reused in four cycles without any significant loss of catalytic activity.
ChemInform Abstract: Efficient Synthesis of N‐(Buta‐2,3‐dienyl) Amides from Terminal N‐Propargyl Amides and Their Synthetic Potential Towards Oxazoline Derivatives.
Authors: Chen Bo , Wang Nan , Fan Wu , Ma Shengming 
Published: March 2013

AbstractA series of N‐allenyl amides (III) prepared from N‐propargyl amides (I) are efficiently transformed into the target oxazole derivatives by palladium‐catalyzed coupling—cyclization reaction with organic iodides (IV).
ChemInform Abstract: Chemotherapy of Leishmaniasis. Part 11. Synthesis and Bioevaluation of Novel Isoxazole Containing Heteroretinoid and Its Amide Derivatives.
Authors: Suryawanshi S. N. , Tiwari Avinash , Chandra Naveen , Ramesh Ramesh , Gupta Suman 
Published: March 2013

AbstractHeteroretinoid (Ib) and its amide (Ic‐i) are synthesized and screened for their in vivo antileishmanial activity against Leishmania donovani in hamsters.
ChemInform Abstract: One‐Pot, Three‐Component Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles Starting from Primary Alcohols.
Authors: Jin Guanyi , Zhang Jian , Fu Dan , Wu Jingjing , Cao Song 
Published: March 2013

AbstractThis method uses mild reaction conditions to give the 1,2,3‐triazoles (III) in good yields.
ChemInform Abstract: PPh3‐Catalyzed [3 + 3] Annulations of 5‐Acetoxypenta‐2,3‐dienoate with 1C,3O‐Bisnucleophiles. Facile Entry to Stable Monocyclic 2H‐Pyrans.
Authors: Hu Jian , Dong Wei , Wu Xin‐Yan , Tong Xiaofeng 
Published: March 2013

AbstractThe procedure allows a convenient access to various 2H‐pyran structures.
ChemInform Abstract: A Facile Four Component Protocol for the Synthesis of Dihydropyridine Derivatives.
Authors: Nair Vijay , Jose Anu , Lakshmi K. C. Seetha , Rajan Rejithamol , Suresh Eringathodi 
Published: March 2013

AbstractBiologically important dihydropyridine derivatives (V) are obtained by the present new method under mild conditions in one step.
ChemInform Abstract: Copper‐Assisted Palladium(II)‐Catalyzed Direct Arylation of Cyclic Enaminones with Arylboronic Acids.
Authors: Kim Yong Wook , Niphakis Micah J. , Georg Gunda I. 
Published: March 2013

AbstractThe title reaction allows an efficient access to a number of arylated target compounds.
ChemInform Abstract: Substitution of the Nitro Group with Grignard Reagents: Facile Arylation and Alkenylation of Pyridine N‐Oxides.
Authors: Zhang Fang , Zhang Song , Duan Xin‐Fang 
Published: March 2013

AbstractReaction of 2‐nitropyridine N‐oxides with aryl‐ and alkenylmagnesium halides provides a new, simple, and efficient method to prepare o‐arylated and o‐alkenylated derivatives.
ChemInform Abstract: One‐Pot Two‐Step Synthesis of 1‐Position Arylated 1,3‐Disubstituted Isoquinoline N‐Oxides.
Authors: Ding Qiuping , Wang Dan , Sang Xiaoyan , Lin Yuqing , Peng Yiyuan 
Published: March 2013

AbstractThe transformation involves an in situ generation of isoquinoline N‐oxides which is followed by a Pd‐mediated direct arylation.
ChemInform Abstract: Ruthenium‐Catalyzed Carbonylation of ortho C—H Bonds in Arylacetamides: C—H Bond Activation Utilizing a Bidentate‐Chelation System.
Authors: Shibata Kaname , Hasegawa Nao , Fukumoto Yoshiyu , Chatani Naoto 
Published: March 2013

AbstractThe presence of a 2‐pyridylmethylamine moiety (Pym) as a bidentate directing group is essential for successful carbonylation of the substrates to produce isoquinoline diones and related heterocyclic systems.
ChemInform Abstract: Ionic Liquids‐Assisted Synthesis of 3,4‐Dihydroisoquinolines by the Bishler—Napieralski Reaction.
Authors: Epishina Margarita A. , Kulikov Alexander S. , Struchkova Marina I. , Ignat'ev Nikolai V. , Schulte Michael , Makhova Nina N. 
Published: March 2013

AbstractThe Bishler—Napieralski cyclodehydration of N‐acyl‐2‐arylethylamines using POCl3 as dehydration reagent gives the corresponding 3,4‐dihydroisoquinolines in ionic liquids in higher yield and under milder conditions compared to conventional organic solvents.
ChemInform Abstract: Three‐Component, One‐Pot Sequential Synthesis of Tetracyclic Pyrido[2′,1′:2,3]imidazo[5,1‐a]isoquinolinium Compounds as Potent Anticancer Agents.
Authors: Zhou Huayong , Wang Wei , Khorev Oleg , Zhang Yongliang , Miao Zehong , Meng Tao , Shen Jingkang 
Published: March 2013

AbstractSome of the synthesized compounds exhibit relatively strong cytotoxicity against the HeLa cell line.
ChemInform Abstract: Straightforward Bienayme and Copper Catalyzed N‐Arylation Sequence to Access Diverse 5H‐Pyrido[2′,1′:2,3]imidazo[4,5‐b]indoles and Analogues.
Authors: El Akkaoui Ahmed , Hiebel Marie‐Aude , Mouaddib Abderrahim , Berteina‐Raboin Sabine , Guillaumet Gerald 
Published: March 2013

AbstractThis is a two‐step sequence of a multicomponent reaction followed by an N‐arylation.
ChemInform Abstract: Concise and Efficient One‐Pot Copper‐Catalyzed Synthesis of H‐Pyrazolo[5,1‐a]isoquinolines.
Authors: Yang Xiaobo , Luo Yue , Jin Yibao , Liu Hongxia , Jiang Yuyang , Fu Hua 
Published: March 2013

AbstractThe simple strategy allows an easy access to the biologically important heterocyclic scaffold and CuI can be used as catalyst in the absence of any additional ligand.
ChemInform Abstract: Rh(I)‐Catalyzed Pauson—Khand‐Type Cycloaddition Reaction of Ene‐vinylidenecyclopropanes with Carbon Monoxide (CO).
Authors: Yuan Wei , Dong Xiang , Shi Min , McDowell Patrick , Li Guigen 
Published: March 2013

AbstractThe method allows an easy and efficient access to tricyclic ring systems which are of biological interest.