bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambulatory Surgery Centers and Their Intended Effects on Outpatient Surgery
Authors: Hollenbeck Brent K. , Dunn Rodney L. , Suskind Anne M. , Strope Seth A. , Zhang Yun , Hollingsworth John M. 
Published: January 2015

ObjectivesTo assess the impact of ambulatory surgery centers (ASCs) on rates of hospital‐based outpatient procedures and adverse events.Data SourcesTwenty percent national sample of Medicare beneficiaries.Study DesignA retrospective study of beneficiaries undergoing outpatient surgery between 2001 and 2010. Health care markets were sorted into three groups—those with ASCs, those without ASCs, and those where one opened for the first time. Generalized linear mixed models were used to assess the impact of ASC opening on rates of hospital‐based outpatient surgery, perioperative mortality, and hospital admission.Principal FindingsAdjusted hospital‐based outpatient surgery rates declined by 7 percent, or from 2,333 to 2,163 procedures per 10,000 beneficiaries, in markets where an ASC opened for the first time (p < .001 for test between slopes). Within these markets, procedure use at ASCs outpaced the decline observed in the hospital setting. Perioperative mortality and admission rates remained flat after ASC opening (both p > .4 for test between slopes).ConclusionsThe opening of an ASC in a Hospital Service Area resulted in a decline in hospital‐based outpatient surgery without increasing mortality or admission. In markets where facilities opened, procedure growth at ASCs was greater than the decline in outpatient surgery use at their respective hospitals.
The Use of the Developmental Rate of the Aquatic Midge Chironomus riparius (Diptera, Chironomidae) in the Assessment of the Postsubmersion Interval
Authors: González Medina Alejandro , Soriano Hernando Óscar , Jiménez Ríos Gilberto 
Published: January 2015

AbstractNonbiting midges (Diptera, Chironomidae) are the most abundant members of the fauna associated with submerged carcasses, but their use in the medicolegal context is very restricted because of their complex ontogeny. In this case, the corpse of a woman was recovered in late spring from a river in Granada (Iberian Peninsula). It showed obvious signs of long permanence in the aquatic environment and, along with pulmonary and microscopical analyses, led to the conclusion that the cause of death was drowning. Several larvae‐like specimens were sampled from the scalp and later identified by morphological external features as IV instar larvae of Chironomus riparius Meigen, 1804 (Diptera, Chironomidae). Sequencing of cytochrome oxidase subunit I was performed to confirm the identification. The knowledge of the biology of C. riparius at low temperatures was critical to assess a postsubmersion interval of 16–17 days.
Peritoneal Dialysis is Limited by Kidney and Liver Volume in Autosomal Dominant Polycystic Kidney Disease
Authors: Hamanoue Satoshi , Hoshino Junichi , Suwabe Tatsuya , Marui Yuji , Ueno Toshiharu , Kikuchi Koichi , Hazue Ryo , Mise Koki , Kawada Masahiro , Imafuku Aya , Hayami Noriko , Sumida Keiichi , Hiramatsu Rikako , Hasegawa Eiko , Sawa Naoki , Takaichi Kennmei , Ubara Yoshifumi 
Published: January 2015

AbstractWe evaluated the influence of kidney volume (KV) and liver volume (LV) on continuation of peritoneal dialysis (PD) in patients with autosomal dominant polycystic kidney disease (PKD). Twenty‐two PKD patients on PD were retrospectively investigated after being divided into two groups. Group 1 comprised 15 patients who started PD at our hospital and group 2 was composed of seven patients referred from other hospitals for treatment of renomegaly by transcatheter arterial embolization (TAE) at 47.1 ± 21.8 months after commencing PD. In group 1, KV for both kidneys (mean ± SD) was 2787 ± 1945 mL (range: 1043 to 6816 mL), LV was 2198 ± 1139 mL (1005 to 4116 mL), and the total organ volume (TV = KV + LV) was 4985 ± 1815 mL (2320 to 8912 mL). In the patient with the largest TV from group 1 (KV of 6816 mL, TV of 8912 mL, and TV/BMI ratio of 426, PD was stopped due to dialysate leakage. However, dialysate leakage did not occur in the other 14 patients (TV ≦ 7963 mL and TV/BMI ratio of 353 at the start of PD). In group 2, KV was 5822 ± 1597 mL (3832 to 8862 mL), LV was 1776 ± 519 mL (1271 to 2671 mL), and TV was 7597 ± 1431 mL (5505 to 10358) before TAE. Leakage of dialysate did not occur with a mean infusion volume of 1530 ± 370 mL (1000 mL to 2000 mL), even after renomegaly and hepatomegaly progressed to the maximum TV/BMI ratio of 359. Six patients from the two groups developed new abdominal hernias at 36 ± 5 months (6–55 months) after starting PD. These findings suggest that performance of PD may be limited by renomegaly and hepatomegaly in patients with PKD.
A rare combination: chylous polyserositis and autoimmune myelofibrosis as a presentation of systemic lupus erythematosus
Authors: Kakar Atul , Pipaliya Keyur , Gogia Atul 
Published: January 2015

AbstractChylous polyserositis and autoimmune myelofibrosis occurring concomitantly inn a case of SLE are a rare phenomenon. We here report a case of a 38‐year‐old woman who was admitted with a history of cough and shortness of breath for 1½ months along with fever and abdominal distension for 1 month. She also had arthralgias, weight loss and pancytopenia. She was diagnosed as a case of SLE with Chylous polyserositis and autoimmune myelofibrosis. She was started on steroids and immunosuppressive therapy, to which she responded.To summarize, this is the first case report where chylous polyserositis and pancytopenia due to autoimmune myelofibrosis occurred which was responsive to steroids and immunosuppressive therapy.
Psychometric Testing of the Spanish Version of the Pain Level Outcome Scale in Hospitalized Patients With Acute Pain
Authors: Bellido‐Vallejo José C. , Rodríguez‐Torres María C. , López‐Medina Isabel M. , Pancorbo‐Hidalgo Pedro L. 
Published: January 2015

PurposeThis study aims to evaluate the psychometric properties and sensitivity to change of the Spanish version of the Pain Level Outcome Scale.MethodsThis article applied observational longitudinal validation study with patients suffering from acute pain at three hospitals.FindingsThe study included 73 patients. Inter‐rater agreement was kappa = .88 and internal consistency α = .93. Principal components analysis yielded four components that explained 81.86% of the variance; the correlation with the Numerical Pain Intensity Scale was r = −.81.ConclusionsThe version with 17 indicators shows good psychometric properties and adequate sensitivity to change. A Spanish version of the Pain Level Outcome Scale with 17 indicators is proposed as a structured multidimensional instrument to help nurses choose the most appropriate indicators for assessing patients’ pain.
Giraffe birth locations in the South Luangwa National Park, Zambia: site fidelity or microhabitat selection?
Authors: Bercovitch Fred B. , Berry Philip S. M. 
Published: January 2015

AbstractBirth site location can have enormous implications for female reproductive success. Some ungulate species demonstrate consistent birth site fidelity, while others shift birth locations during their lifetimes as a function of ecological and social factors. We plotted 39 years of birth records from a wild population of Thornicroft's giraffe, Giraffa camelopardalis thornicrofti, to test the hypothesis that giraffe use consistent locations for birth. Data from 29 calves born to nine females revealed that birth seasonality was absent and that ecological zone had no significant impact on birth locations. Consecutive births by individual females were not limited to certain locations, with the distance between sequential birth sites tending to be greater if a calf failed to survive the first year of life. Our evidence conflicts with the suggestion that giraffe cows regularly return to special locations for bearing calves. We suggest that the choice of birth location is a function of nonseasonal breeding, predator pressure and extensive variation in microhabitat characteristics within ecological zones. Female giraffe have evolved a flexible reproductive strategy, whereby they regulate choice of birth site location based upon their past reproductive history, current ecological conditions (including both resource availability and predator pressure) and present social surroundings.
A randomised controlled trial of periconal eye blockade with or without ultrasound guidance
Authors: Najman I. E. , Meirelles R. , Ramos L. B. , Guimarães T. C. F. , do Nascimento P. 
Published: January 2015

SummaryWe randomly allocated 129 participants with normal eyes to periconal blockade with (n = 69) or without (n = 60) ultrasound guidance before cataract surgery. There was no difference in the rates of complication, 1/69 and 0/60, respectively, p = 1.0. The rate of intraconal needle placement was 1/69 with ultrasound and 12/60 without ultrasound, a relative risk (95% CI) of 0.07 (0.01–0.55), p < 0.0001.
Utility of neoadjuvant chemotherapy in the treatment of operable breast cancer
Authors: Read Rebecca L. , Flitcroft Kathy , Snook Kylie L. , Boyle Frances M. , Spillane Andrew J. 
Published: January 2015

AbstractNeoadjuvant chemotherapy (NAC) is a legitimate alternative to first‐line surgical therapy for the treatment of breast cancer patients, as level one evidence shows the effect on overall survival is equivalent to that of adjuvant chemotherapy. In the treatment of women with operable breast cancer, NAC provides a number of potential advantages including: improving the chance of achieving breast‐conserving surgery, improving cosmesis after breast‐conserving surgery, downstaging the breast and axilla, allowing time to fully consider surgical options, time for genetic testing and facilitating breast reconstruction in otherwise high‐risk patients. However, in Australia, NAC is poorly utilized with less than 3% of women with operable breast cancer receiving NAC. This review discusses the potential harms and benefits of NAC, discusses areas of controversy in the use of NAC and describes how we have used NAC in our own practice. We conclude that if it is obviously necessary for the newly presenting breast cancer patient to have chemotherapy as part of the treatment, it is worth considering NAC. In many patients, the potential benefits of NAC outweigh the harms. However, maximizing these benefits is closely aligned with appropriate patient selection and timely multidisciplinary team communication.
Identification of a novel E‐box binding pyrrole‐imidazole polyamide inhibiting MYC‐driven cell proliferation
Authors: Mishra Rajeev , Watanabe Takayoshi , Kimura Makoto T. , Koshikawa Nobuko , Ikeda Maki , Uekusa Shota , Kawashima Hiroyuki , Wang Xiaofei , Igarashi Jun , Choudhury Diptiman , Grandori Carla , Kemp Christopher J. , Ohira Miki , Verma Narendra K. , Kobayashi Yujin , Takeuchi Jin , Koshinaga Tsugumichi , Nemoto Norimichi , Fukuda Noboru , Soma Masayoshi , Kusafuka Takeshi , Fujiwara Kyoko , Nagase Hiroki 
Published: January 2015

The MYC transcription factor plays a crucial role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. Due to its oncogenic activities and overexpression in a majority of human cancers, it is an interesting target for novel drug therapies. MYC binding to the E‐box (5′‐CACGTGT‐3′) sequence at gene promoters contributes to more than 4000 MYC‐dependent transcripts. Owing to its importance in MYC regulation, we designed a novel sequence‐specific DNA‐binding pyrrole–imidazole (PI) polyamide, Myc‐5, that recognizes the E‐box consensus sequence. Bioinformatics analysis revealed that the Myc‐5 binding sequence appeared in 5′‐ MYC binding E‐box sequences at the eIF4G1, CCND1, and CDK4 gene promoters. Furthermore, ChIP coupled with detection by quantitative PCR indicated that Myc‐5 has the ability to inhibit MYC binding at the target gene promoters and thus cause downregulation at the mRNA level and protein expression of its target genes in human Burkitt's lymphoma model cell line, P493.6, carrying an inducible MYC repression system and the K562 (human chronic myelogenous leukemia) cell line. Single i.v. injection of Myc‐5 at 7.5 mg/kg dose caused significant tumor growth inhibition in a MYC‐dependent tumor xenograft model without evidence of toxicity. We report here a compelling rationale for the identification of a PI polyamide that inhibits a part of E‐box‐mediated MYC downstream gene expression and is a model for showing that phenotype‐associated MYC downstream gene targets consequently inhibit MYC‐dependent tumor growth.
Peroxisome Proliferator‐activated Receptor‐γ Agonist Pioglitazone Ameliorates White Matter Lesion and Cognitive Impairment in Hypertensive Rats
Authors: Lan Lin‐Fang , Zheng Lu , Yang Xian , Ji Xiao‐Tan , Fan Yu‐Hua , Zeng Jin‐Sheng 
Published: January 2015

SummaryAimsCerebrovascular white matter lesion (WML) is a major subtype of cerebral small vessel disease. Clinical drugs are not available for WML. We investigated whether peroxisome proliferator‐activated receptor‐γ agonist pioglitazone, with properties of vascular protection and antiinflammation, exerts beneficial effect in hypertensive WML rats.MethodsStroke‐prone renovascular hypertensive rats (RHRSP) were treated with pioglitazone for 12 weeks. Morris water maze experiment was conducted to assess cognition. WML was observed by Luxol fast blue staining. Smooth muscle actin‐alpha, collagen I, collagen IV, glial fibrillary acidic protein, and ionized calcium‐binding adaptor molecule‐1 were evaluated by immunohistochemistry. Interleukin‐1 beta (IL‐1β) and tumor necrosis factor alpha (TNF‐α) in brain and soluble intercellular adhesion molecule‐1 (sICAM‐1) in serum were detected.ResultsPioglitazone significantly attenuated WML in corpus callosum, caudate putamen, external capsule, and internal capsule. Cognitive impairment in RHRSP was ameliorated by pioglitazone. Pioglitazone attenuated arteriolar remodeling and reduced sICAM‐1 level in serum. Pioglitazone decreased the proliferation of microglia and astrocyte and lowered the expression of proinflammatory cytokines IL‐1β and TNF‐α in the white matter.ConclusionsLong‐term treatment of pioglitazone has beneficial effect on hypertension‐induced WML and cognition decline, which may partly through its effect on attenuation of arteriolar remodeling, endothelial activation, and brain inflammation.
Regional lymph node status after neoadjuvant chemoradiation of rectal cancer producing a complete or near complete rectal wall response
Authors: Shwaartz C. , Haim N. , Rosin D. , Lawrence Y. , Gutman M. , Zmora O. 
Published: January 2015

AbstractAimTransanal excision of the tumour site after complete response to chemoradiotherapy can determine the rectal wall response to treatment. This study was designed to assess whether the absence of tumour in the rectal wall corresponds to the absence of tumour in the mesorectum (true pathological complete response).MethodA retrospective review identified patients who underwent preoperative chemoradiation therapy for advanced mid and low rectal cancer followed by routine pre‐planned radical surgery with total mesorectal excision. Patients in whom the pathology specimen showed no residual tumour in the rectal wall (ypT0) or a ypT1 lesion were assessed for tumour involvement in the mesorectum.ResultsSeventy‐eight patients who underwent pelvic chemoradiation followed by radical surgery were reviewed. The rectal wall tumour disappeared in eight (ypT0). Of these, residual tumour was found in the mesorectum (ypT0N1) in one (12%) patient. Eleven patients were found to have ypT1 residual tumour. Of these, two (18%) had a final post‐surgical staging of ypT1N1.ConclusionComplete rectal wall tumour eradication was achieved in 10% of the patients, and downstaging to ypT1 was achieved in 14%. In 15% (12% in ypT0 and 18% in ypT1) of these patients, residual tumour cells were evident in the mesorectum. This would probably have rendered these patients with residual disease had a nonradical approach of transanal excision of the original tumour site been employed. Caution should be taken when considering the avoidance of radical surgery.
Effects of motor action on affective preferences in autism spectrum disorders: different influences of embodiment
Authors: Eigsti Inge‐Marie , Rosset Delphine , Col Cozzari Ghislaine , da Fonseca David , Deruelle Christine 
Published: January 2015

AbstractIn the embodied cognition framework, sensory, motor and emotional experiences are encoded along with sensorimotor cues from the context in which information was acquired. As such, representations retain an initial imprint of the manner in which information was acquired. The current study reports results indicating a lack of embodiment effects in ASD and, further, an association between embodiment differences and ASD symptomatology. The current results are consistent with an embodied account of ASD that goes beyond social experiences and could be driven by subtle deficits in sensorimotor coordination.
GADA and anti‐ZnT8 complicate the outcome of phenotypic type 2 diabetes of adults
Authors: Haller‐Kikkatalo Kadri , Pruul Katrin , Kisand Kalle , Nemvalts Virge , Reimand Koit , Uibo Raivo 
Published: January 2015

AbstractBackgroundA proportion of phenotypic type 2 diabetes (T2D) patients produce pancreatic autoantibodies and a majority of T2D patients develop serious life‐disabling complications over time despite the implementation of adequate clinical interventions. This study determined whether the presence of pancreatic autoantibodies (GADA, IA‐2A, anti‐ZnT8, or ICA) was associated with serious complications or concomitant diseases of adult patients diagnosed with T2D (N = 305).Main resultsIn the study population, 22·3% (N = 68) of subjects were positive for at least 1 of the 4 of the markers associated with autoimmune diabetes (presence of pancreatic autoantibody – pAb), followed by GADA (14·1%, N = 43), ICA (8·9%, N = 27), anti‐ZnT8 (5·6%, N = 17) and IA‐2A (2·0%, N = 6). Logistic regression analysis adjusted for patient's age, gender and duration of T2D revealed that (i) pAb was associated with higher prevalence of adiposity (odds ratio of adjusted regression model (adOR) 2·51, P = 0·032); (ii) pAb, GADA and anti‐ZnT8 were associated with autoimmune thyroid disease (adORs 3·07, P = 0·012; 6·29, P < 0·001 and 3·52, P = 0·052, respectively); (iii) pAb and GADA, in particular, were risk factors for neurological complications (adORs 2·10, P = 0·036; 2·76, P = 0·009, respectively) and polyneuropathy in particular (adORs 2·60, P = 0·012; 3·10, P = 0·007, respectively); and (iv) anti‐ZnT8 was a risk factor for developing nephropathy (adOR 4·61, P = 0·022). In addition, adiposity was associated with 5·3‐year earlier onset of disease (adjusted linear regression model, P = 0·006).ConclusionsThese results suggest that GADA and anti‐ZnT8 are associated with progression of serious T2D complications, including polyneuropathy and nephropathy. In addition, adiposity represents a significant risk for autoimmunity development in T2D patients.
Alterations in the mechanical properties of the extracted human teeth to be used as biological restorations on storing them in different storage media: an in vitro study
Authors: Kantoor Pallavi , Srivastava Nikhil , Rana Vivek , Adlakha Vivek K. 
Published: January 2015

AbstractBackgroundTotal or partial loss of tooth structure occured due to caries or trauma. The decayed or fractured tooth is restored with appropriate restorative materials. A range of restorative materials are available in the market today, but each of them has one or the other drawbacks, viz. color mismatch, variable wear resistance, and strength. Therefore, there has always been a quest to use a restorative material which has properties as close to natural tooth as possible. Extracted human teeth have been tried as restorative materials with good success rate, but their storage has been a problem due to change in physical properties.Aims and objectivesTo evaluate the changes in the mechanical properties of the extracted human teeth to be used as biological restoration upon storing them in different storage media and to compare their effectiveness.Material and methodologyFive hundred and twenty extracted human teeth (samples) included in the study were equally distributed and randomly stored in different storage media (saline, artificial saliva, ORS, coconut water, and eye solution), and their mechanical properties were checked at different time intervals (7, 14, and 30 days) using universal testing machine and Vickers hardness test.Result and conclusionNone of the storage media used in the study significantly altered mechanical properties of the stored extracted human teeth except the hardness which was substantially reduced after storing for 30 days. Of the 4 media tested, eye solution was found to be the best, while artificial saliva was found to be least effective as storage media. It was also concluded that storage time of the extracted teeth to be used as biological restorations should not exceed more than 3–4 weeks as beyond this time, mechanical properties namely hardness get altered significantly.
Polymorphism of the E‐cadherin gene CDH1 is associated with susceptibility to vitiligo
Authors: Tarlé Roberto Gomes , Silva de Castro Caio Cesar , do Nascimento Liliane Machado , Mira Marcelo Távora 
Published: January 2015

AbstractVitiligo is a depigmenting disorder characterized by loss of functional melanocytes from the epidermis. Experimental data suggest that defective melanocyte adhesion may underlie the pathogenesis of the disease. In particular, association between vitiligo and genetic variants of the DDR1 gene involved in melanocyte adhesion has been recently published. A subsequent, independent study revealed lower expression of DDR1 in vitiligo lesions. Here, we expand this investigation by testing for association between vitiligo and polymorphisms of CDH1, IL1B and NOV (formerly CCN3), genes belonging to the DDR1 adhesion pathway, in two population samples of distinct design. Our results reveal that alleles of marker rs10431924 of the CDH1 gene are associated with vitiligo, especially in the presence of autoimmune comorbidities.
Acupuncture for low back pain: ritual healing or medicine?
Authors: Kavoussi Ben 
Published: January 2015

AbstractBackgroundLow back pain (LBP) is a prevalent and costly condition that is poorly amenable to medical care. Both patients and clinicians occasionally resort to non‐medical healing such as acupuncture.ObjectivesThe aim of this narrative review is to evaluate acupuncture's claim of efficacy as an adjunct or alternative therapy for the treatment of non‐specific, non‐inflammatory LBP with no neurological symptoms.MethodsEvidence was collected from clinical trials, meta‐analyses and systematic reviews conducted in the USA or in Europe. Studies were all published in English, conducted within the last 10 years, and identified exclusively from PubMed, CINAHL and the Cochrane Collaboration.ResultsCollectively, recent RCTs and systematic reviews provide consistent evidence that acupuncture according to its traditional theories is no more effective for LBP than various forms of non‐invasive controls, including pricking the skin with a toothpick at non‐acupuncture points. This finding not only undermines the traditional tenets of acupuncture, but also discredits its claim of specific effects for LBP.ConclusionsIf the effects of acupuncture on LBP are mainly due to the treatment ritual or to other psychological factors, then the placebo nature of the treatment must be fully disclosed; otherwise, patients will not be making an informed medical decision. Moreover, the use of acupuncture for LBP might directly conflict with the current positions of the American Medical Association, the American Osteopathic Association, the American Pain Society and the American Society for Pain Management Nursing on the use of placebo for the treatment of pain.