bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of luseogliflozin on suspected MASLD in patients with diabetes: a pooled meta-analysis of phase III clinical trials
Authors: Kawaguchi Takumi , Murotani Kenta , Kajiyama Hiromitsu , Obara Hitoshi , Yamaguchi Hironori , Toyofuku Yuko , Kaneko Fumi , Seino Yutaka , Uchida Saeko 
Published: July 2024

Abstract
Background
Luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, potentially exerts pleiotropic effects on the liver. However, the sufficient evidence is still lacking. We aimed to investigate the effects of luseogliflozin on hepatic steatosis, fibrosis, and cardiometabolic risk factors in diabetic patients by a pooled meta-analysis.

Methods
In this pooled meta-analysis, we enrolled diabetic patients who participated in phase III clinical trials of luseogliflozin (luseogliflozin group n = 302, placebo group n = 191). The primary outcomes were changes in fatty liver index (FLI) and Hepamet fibrosis score (HFS) after 24 weeks. The secondary outcomes were changes in cardiometabolic risk factors after 24 weeks. Statistical analysis was performed using propensity scoring analysis by the inverse probability of treatment weighting method.

Results
Primary outcomes: Luseogliflozin significantly decreased FLI compared to placebo after 24 weeks (adjusted coefficient − 5.423, 95%CI − 8.760 to − 2.086, P = 0.0016). There was no significant difference in changes in HFS between the two groups. However, luseogliflozin significantly decreased HFS compared to placebo in diabetic patients with ALT > 30 U/L (adjusted coefficient − 0.039, 95%CI − 0.077 to − 0.001, P = 0.0438) and with FIB-4 index > 1.3 (adjusted coefficient − 0.0453, 95%CI − 0.075 to − 0.016, P = 0.0026). Secondary outcom8es: Luseogliflozin significantly decreased HbA1c level, HOMA-IR value, BMI, and uric acids level, and increased HDL cholesterol level compared to placebo.

Conclusions
This pooled meta-analysis demonstrated that 24-week treatment with luseogliflozin improved hepatic steatosis and fibrosis indexes in diabetic patients, especially those with liver injury. Furthermore, luseogliflozin improved various cardiometabolic risk factors. Thus, luseogliflozin may be useful for improving MASLD in diabetic patients.

Graphical abstract
Profile of plasma microRNAs as a potential biomarker of Wilson’s disease
Authors: Sánchez-Monteagudo Ana , Ripollés Edna , Murillo Oihana , Domènech Sofia , Álvarez-Sauco María , Girona Eva , Sastre-Bataller Isabel , Bono Ariadna , García-Villarreal Luis , Tugores Antonio , García-García Francisco , González-Aseguinolaza Gloria , Berenguer Marina , Espinós Carmen 
Published: July 2024

Abstract
Background
Wilson’s disease (WD) is a rare condition resulting from autosomal recessive mutations in ATP7B, a copper transporter, manifesting with hepatic, neurological, and psychiatric symptoms. Timely diagnosis and appropriate treatment yield a positive prognosis, while delayed identification and/or insufficient therapy lead to a poor outcome. Our aim was to establish a prognostic method for WD by characterising biomarkers based on circulating microRNAs.

Methods
We conducted investigations across three cohorts: discovery, validation (comprising unrelated patients), and follow-up (revisiting the discovery cohort 3 years later). All groups were compared to age- and gender-matched controls. Plasma microRNAs were analysed via RNA sequencing in the discovery cohort and subsequently validated using quantitative PCR in all three cohorts. To assess disease progression, we examined the microRNA profile in Atp7b−/− mice, analysing serum samples from 6 to 44 weeks of age and liver samples at three time points: 20, 30, and 40 weeks of age.

Results
In patients, elevated levels of the signature microRNAs (miR-122-5p, miR-192-5p, and miR-885-5p) correlated with serum activities of aspartate transaminase, alanine aminotransferase and gamma-glutamyl transferase. In Atp7b−/− mice, levels of miR-122-5p and miR-192-5p (miR-885-5p lacking a murine orthologue) increased from 12 weeks of age in serum, while exhibiting fluctuations in the liver, possibly attributable to hepatocyte regenerative capacity post-injury and the release of hepatic microRNAs into the bloodstream.

Conclusions
The upregulation of the signature miR-122-5p, miR-192-5p, and miR-885-5p in patients and their correlation with liver disease progression in WD mice support their potential as biomarkers of WD.
Towards fully automated processing and analysis of construction diagrams: AI-powered symbol detection
Authors: Jamieson Laura , Moreno-Garcia Carlos Francisco , Elyan Eyad 
Published: July 2024

AbstractConstruction drawings are frequently stored in undigitised formats and consequently, their analysis requires substantial manual effort. This is true for many crucial tasks, including material takeoff where the purpose is to obtain a list of the equipment and respective amounts required for a project. Engineering drawing digitisation has recently attracted increased attention, however construction drawings have received considerably less interest compared to other types. To address these issues, this paper presents a novel framework for the automatic processing of construction drawings. Extensive experiments were performed using two state-of-the-art deep learning models for object detection in challenging high-resolution drawings sourced from industry. The results show a significant reduction in the time required for drawing analysis. Promising performance was achieved for symbol detection across various classes, with a mean average precision of 79% for the YOLO-based method and 83% for the Faster R-CNN-based method. This framework enables the digital transformation of construction drawings, improving tasks such as material takeoff and many others.
Association between physical activity and the prevalence of gout among patients with type 2 diabetes mellitus and hyperuricemia: a two-center population-based cross-sectional study
Authors: Cai Ningyu , Chen Mengdie , Wu Lijing , Feng Ping , Ye Xun , Liu Qiao , Zhu Xianping , Lu Chaoyin , Zheng Qidong , Wang Yiyun 
Published: July 2024

Abstract
Introduction
Diabetes mellitus (DM) and gout cohabitation severely reduces patient life quality while raising financial burden on individual and society. The aim of this study was to elucidate the association between physical activity (PA) and the prevalence of gout among type 2 DM (T2DM) and hyperuricemia (HUA) patients.

Methods
In all, we recruited 2291 T2DM patients with HUA. Among them, 448 had gout and 1843 did not. We collected patient data, such as anthropometry, laboratory reports, and medical history, for our analyses. The PA assessment was based on the Chinese version of International PA Questionnaire-short (IPAQ). Moreover, the relationship between PA and gout risk was examined using multivariate logistic regression models.

Results
Total PA was markedly low among gout patients, relative to controls (p < 0.05). Based on the IPAQ categorical score, 38.2% exhibited “low,” 26.8% “moderate,” and 35.0% “high” PA among gout patients. In comparison, 12.4% performed “low,” 53.8% “moderate,” and 33.8% “high” PA among controls. Multivariate analysis revealed that, after adjustment of confounding factors, both low (OR 6.382) and high PA (OR 2.048) had a higher prevalence of gout, as compared to moderate PA. Moreover, we revealed that the male sex, age, HUA duration, serum uric acid, glycated hemoglobin, dyslipidemia history, and drinking status were also independent indicators of the prevalence of gout. Furthermore, stratification analyses revealed results consistent with our prior results.

Conclusions
PA intensity was associated with the prevalence of gout among T2DM and HUA patients, and the lowest prevalence was achieved from moderate intensity PA.

Key Points

• PA intensity was associated with the prevalence of gout among T2DM and HUA patients.

• The lowest prevalence of gout was achieved from moderate intensity PA.
Do sheep (Ovis aries) discriminate human emotional odors?
Authors: Larrigaldie Izïa , Damon Fabrice , Mousqué Solène , Patris Bruno , Lansade Léa , Schaal Benoist , Destrez Alexandra 
Published: July 2024

Abstract
While sheep can detect and discriminate human emotions through visual and vocal cues, their reaction to human body odors remains unknown. The present study aimed to determine whether sheep (Ovis aries) can detect human odors, olfactorily discriminate stressed from non-stressed individuals, and behave accordingly based on the emotional valence of the odors. Axillary secretions from 34 students were collected following an oral examination (stress odor) or a regular class (non-stress odor). Fourteen female and 15 male lambs were then exposed to these odors through a habituation-dishabituation procedure. The habituation stimulus was presented four times for one minute, followed by the dishabituation stimulus presented once for one minute. Behavioral variables included spatiality relative to target odors, approach/withdrawal, ear positioning, sniffing, ingestion, and vocalization. Both female and male lambs more often positioned their ears backwards/forwards, and asymmetrically when exposed to the dishabituation stimulus, but regardless of their stress or non-stress value. They also changed their approach behavior when exposed to the dishabituation stimuli. Lambs displayed some behavioral signs of discrimination between the habituation and dishabituation odors, but regardless of their relation to stress or non-stress of human donors. In sum, this exploratory study suggests that young sheep respond negatively to the odor of unfamiliar humans, without showing any specific emotional contagion related to the stress odor. This exploratory study suggests young ovines can detect human body odor, a further step toward understanding the human-sheep relationship.
On-Field Evaluation of Mouthpiece-and-Helmet-Mounted Sensor Data from Head Kinematics in Football
Authors: Holcomb Ty D. , Marks Madison E. , Pritchard N. Stewart , Miller Logan E. , Rowson Steve , Bullock Garrett S. , Urban Jillian E. , Stitzel Joel D. 
Published: July 2024

Abstract
Purpose
Wearable sensors are used to measure head impact exposure in sports. The Head Impact Telemetry (HIT) System is a helmet-mounted system that has been commonly utilized to measure head impacts in American football. Advancements in sensor technology have fueled the development of alternative sensor methods such as instrumented mouthguards. The objective of this study was to compare peak magnitude measured from high school football athletes dually instrumented with the HIT System and a mouthpiece-based sensor system.

Methods
Data was collected at all contact practices and competitions over a single season of spring football. Recorded events were observed and identified on video and paired using event timestamps. Paired events were further stratified by removing mouthpiece events with peak resultant linear acceleration below 10 g and events with contact to the facemask or body of athletes.

Results
A total of 133 paired events were analyzed in the results. There was a median difference (mouthpiece subtracted from HIT System) in peak resultant linear and rotational acceleration for concurrently measured events of 7.3 g and 189 rad/s2. Greater magnitude events resulted in larger kinematic differences between sensors and a Bland Altman analysis found a mean bias of 8.8 g and 104 rad/s2, respectively.

Conclusion
If the mouthpiece-based sensor is considered close to truth, the results of this study are consistent with previous HIT System validation studies indicating low error on average but high scatter across individual events. Future researchers should be mindful of sensor limitations when comparing results collected using varying sensor technologies.
Locally Coherent Exact Categories
Authors: Positselski Leonid 
Published: July 2024

AbstractA locally coherent exact category is a finitely accessible additive category endowed with an exact structure in which the admissible short exact sequences are the directed colimits of admissible short exact sequences of finitely presentable objects. We show that any exact structure on a small idempotent-complete additive category extends uniquely to a locally coherent exact structure on the category of ind-objects; in particular, any finitely accessible category has the unique maximal and the unique minimal locally coherent exact category structures. All locally coherent exact categories are of Grothendieck type in the sense of Št’ovíček. We also discuss the canonical embedding of a small exact category into the abelian category of additive sheaves in connection with the locally coherent exact structure on the ind-objects, and deduce two periodicity theorems as applications.
Outcomes of community-led urban rat control on avifauna
Authors: Gerolemou Rosie V. , Russell James C. , Stanley Margaret C. 
Published: July 2024

AbstractCities are increasingly recognised as important sites for biodiversity and essential for improving human-nature connections. However, urban areas are also hotspots for rats, which negatively impact biodiversity due to competition and depredation. Urban residents may undertake rat control on their properties, but the effectiveness of such volunteer initiatives for broader biodiversity outcomes has not been tested in urban environments. We conducted a comprehensive study inclusive of rat abundance, adult bird diversity, and bird breeding success. We monitored rat (Norway rat Rattus norvegicus; ship rat Rattus rattus) presence and modelled detection probabilities and occupancy in suburban residential backyards in Auckland, New Zealand. We also compared bird abundance and richness among backyards and recorded 140 nesting attempts from 15 bird species between September 2021 and February 2022. Despite rat control, rats were detected at some point in all backyards, though relative abundance was low, and fewer rats were detected in backyards with more frequent rat control. Higher bird abundance, and to a lesser extent richness, were associated with proximity to native vegetation patches and more frequent rat control. Overall fledging success was relatively high and predation by rats was relatively low compared to previous research. Nest survival was slightly higher for introduced bird species. Daily nest survival rate increased with nest height, proximity to native vegetation patches, and when rat detection rates decreased. Although the effect was small, frequent rat control within a backyard was associated with increased fledging success and increased bird species richness and abundance. Further research is required to explore the factors that interact with backyard rat control to improve local outcomes for birds. High levels of community participation in backyard rat control are required to improve neighbourhood-wide outcomes for birds.
Parallelly Sliced Optimal Transport on Spheres and on the Rotation Group
Authors: Quellmalz Michael , Buecher Léo , Steidl Gabriele 
Published: July 2024

AbstractSliced optimal transport, which is basically a Radon transform followed by one-dimensional optimal transport, became popular in various applications due to its efficient computation. In this paper, we deal with sliced optimal transport on the sphere $$\mathbb {S}^{d-1}$$

S

d
-
1

and on the rotation group $$\textrm{SO}(3)$$

SO
(
3
)

. We propose a parallel slicing procedure of the sphere which requires again only optimal transforms on the line. We analyze the properties of the corresponding parallelly sliced optimal transport, which provides in particular a rotationally invariant metric on the spherical probability measures. For $$\textrm{SO}(3)$$

SO
(
3
)

, we introduce a new two-dimensional Radon transform and develop its singular value decomposition. Based on this, we propose a sliced optimal transport on $$\textrm{SO}(3)$$

SO
(
3
)

. As Wasserstein distances were extensively used in barycenter computations, we derive algorithms to compute the barycenters with respect to our new sliced Wasserstein distances and provide synthetic numerical examples on the 2-sphere that demonstrate their behavior for both the free- and fixed-support setting of discrete spherical measures. In terms of computational speed, they outperform the existing methods for semicircular slicing as well as the regularized Wasserstein barycenters.
Raw clay material-based modified carbon paste electrodes for sensitive heavy metal detection in drinking water
Authors: Sanou Ali , Coulibaly Mariame , N’dri Seiny Roger , Tămaș Tudor Liviu , Bizo Liliana , Frentiu Tiberiu , Covaci Eniko , Abro Koutouan Désiré Martial , Dablé Pierre Jean-Marie Richard , Yao Kouassi Benjamin , Fort Carmen Ioana , Turdean Graziella Liana 
Published: July 2024

AbstractA new electrode based on carbon paste (CP) modified with natural clay was used for heavy metals detection. The investigation of the raw clay material (X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, thermal analysis and particle size distribution) revealed different morpho-structural properties of the natural material. The electrochemical behaviour of the modified carbon paste electrode and its ability to detect heavy metals (Zn2+, Cd2+, and Cu2+) was studied by different electrochemical techniques like cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square wave anodic stripping voltammetry (SWASV). Both electrochemical and analytical parameters of the investigated modified electrode recommend them as stable, sensitive and reproducible sensors for individual heavy metals detection.
Time Scale Calculus: a new approach to multi-dose pharmacokinetic modeling
Authors: Arteaga-Bejarano José Ricardo , Torres Santiago 
Published: July 2024

AbstractIn this paper, we use Time Scale Calculus (TSC) to formulate and solve pharmacokinetic models exploring multiple dose dynamics. TSC is a mathematical framework that allows the modeling of dynamical systems comprising continuous and discrete processes. This characteristic makes TSC particularly suited for multi-dose pharmacokinetic problems, which inherently feature a blend of continuous processes (such as absorption, metabolization, and elimination) and discrete events (drug intake). We use this toolkit to derive analytical expressions for blood concentration trajectories under various multi-dose regimens across several flagship pharmacokinetic models. We demonstrate that this mathematical framework furnishes an alternative and simplified way to model and retrieve analytical solutions for multi-dose dynamics. For instance, it enables the study of blood concentration responses to arbitrary dose regimens and facilitates the characterization of the long-term behavior of the solutions, such as their steady state.
A new model with uniform damping force for frictionless impacts with non-permanent deformation at the time of separation
Authors: Poursina Mohammad , Nikravesh Parviz E. 
Published: July 2024

Abstract
This paper presents a new approach to modeling the contact force in continuous method of modeling an impact. This method considers the traditionally used Hertz spring force to represent the elastic behavior of the impact. A new nonlinear damping force is introduced to model the energy dissipation during the impact. Unlike the traditional spring-damping force elements used in some continuous contact force models, the introduced nonlinear damper can address impacts with non-permanent local deformation at the time of separation. We conduct both analytical and numerical investigations to mathematically express the damping factor as an explicit function of system parameters. In order to ensure that the presented force model can recover the desired restitution, an optimization approach is introduced and implemented to determine the optimal damping factor. The proposed force model is numerically verified on random systems. Finally, this new model is used to study the behavior of two colliding pendulums along with well-established piecewise and continuous approaches for modeling impacts.
LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
Authors: Chen Yifei , Cui Hengxiang , Han Zhuanzhuan , Xu Lei , Wang Lin , Zhang Yuefei , Liu Lijun 
Published: July 2024

AbstractThe non-coding RNA LINC00894 modulates tumor proliferation and drug resistance. However, its role in brain is still unclear. Using RNA-pull down combined with mass spectrometry and RNA binding protein immunoprecipitation, EIF5 was identified to interact with LINC00894. Furthermore, LINC00894 knockdown decreased EIF5 protein expression, whereas LINC00894 overexpression increased EIF5 protein expression in SH-SY5Y and BE(2)-M17 (M17) neuroblastoma cells. Additionally, LINC00894 affected the ubiquitination modification of EIF5. Adeno-associated virus (AAV) mediated LINC00894 overexpression in the brain inhibited the expression of activated Caspase-3, while increased EIF5 protein level in rats and mice subjected to transient middle cerebral artery occlusion reperfusion (MCAO/R). Meanwhile, LINC00894 knockdown increased the number of apoptotic cells and expression of activated Caspase-3, and its overexpression decreased them in the oxygen–glucose deprivation and reoxygenation (OGD/R) in vitro models. Further, LINC00894 was revealed to regulated ATF4 protein expression in condition of OGD/R and normoxia. LINC00894 knockdown also decreased the expression of glutamate-cysteine ligase catalytic subunit (GCLC) and ATF4, downregulated glutathione (GSH), and the ratio of GSH to oxidized GSH (GSH: GSSG) in vitro. By using RNA-seq combined with qRT-PCR and immunoblot, we identified that fibroblast growth factor 21 (FGF21) and aconitate decarboxylase 1 (ACOD1), as the ATF4 target genes were regulated by LINC00894 in the MCAO/R model. Finally, we revealed that ATF4 transcriptionally regulated FGF21 and ACOD1 expression; ectopic overexpression of FGF21 or ACOD1 in LINC00894 knockdown cells decreased activated Caspase-3 expression in the OGD/R model. Our results demonstrated that LINC00894 regulated cerebral ischemia injury by stabilizing EIF5 and facilitating EIF5-ATF4-dependent induction of FGF21 and ACOD1.
Ecological Grief, Religious Coping, and Spiritual Crises: Exploring Eco-Spiritual Grief
Authors: Pihkala Panu 
Published: July 2024

Abstract
Ecological grief results from human-caused environmental changes. While it is a growing subject of study, research on the relationship between it and spirituality/religion remains scarce. This article explores the topic by focusing on the frameworks of religious coping and (complicated) spiritual grief. Religion and spirituality can be resources for coping with ecological grief, but there can also be difficulties which cause spiritual grief: crises about beliefs, estrangement from one’s spiritual community, and disruption in spiritual practice. The author proposes a new term for the combinations of ecological and spiritual grief: eco-spiritual grief. Frameworks of religious coping (the RCOPE) and spiritual grief (the Inventory of Complicated Spiritual Grief, ICSG) are analyzed in relation to ecological grief and eco-spiritual grief. The author argues that elements in these frameworks can be useful in relation to ecological grief and spirituality, but modifications should be made for this particular topic. Research about ecological grief should avoid individualizing tendencies, strong anthropocentrism, and a narrow focus on monotheism. Some items in the RCOPE and ICSG are especially relevant for monotheism, but they could be broadened to include other forms of spirituality. Themes for nuanced research about the matter are charted. The results are relevant for anyone who wants to explore the intersections of spirituality/religion and ecological grief, as well as theology and psychology, and they have special relevance for researchers and (pastoral) psychologists.