bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unconventional cold vortex as precursor to historic early summer heatwaves in North China 2023
Authors: Liu Boqi , Duan Yanan , Ma Shuangmei , Yan Yuhan , Zhu Congwen 
Published: July 2024

AbstractIn mid-June to July 2023, North China witnessed extreme heatwaves, marked by intense near-surface warming with an advanced seasonal cycle of local air temperature. An unconventional upper-tropospheric cold vortex in early June, deviating from conventional “heat dome” patterns, preceded the heatwave extremes. The zonal SSTA gradient in Indo-Pacific warm pool initially suppressed Indian summer monsoon convection, which stimulated the cold vortex around North China via a tropical-extratropical teleconnection. This anomaly intensified the air-land thermal contrast, leading to increased sensible heating and reduced soil moisture in situ. The drier soil conditions maintained and further augmented sensible heating, escalating surface air temperature, and culminating in extraordinary heatwaves. The air column was then destabilized to mitigate the upper-level cold vortex. Historical records corroborate the extremity of the air-sea interactions in 2023. The ECMWF real-time subseasonal-to-seasonal (S2S) forecasts successfully capture the air-land feedback in both cold vortex and heatwave stages, albeit with an underestimation of heatwave intensity due to biases in soil moisture anomalies. Consequently, the initial cold vortex condition and air-land-sea interactions yield S2S predictability to the historic 2023 heatwaves in North China.
Quantifying stress distribution in ultra-large graphene drums through mode shape imaging
Authors: Sarafraz Ali , Liu Hanqing , Cvetanović Katarina , Spasenović Marko , Vollebregt Sten , Manzaneque Garcia Tomás , Steeneken Peter G. , Alijani Farbod , Verbiest Gerard J. 
Published: July 2024

AbstractSuspended drums made of 2D materials hold potential for sensing applications. However, the industrialization of these applications is hindered by significant device-to-device variations presumably caused by non-uniform stress distributions induced by the fabrication process. Here, we introduce a methodology to determine the stress distribution from their mechanical resonance frequencies and corresponding mode shapes as measured by a laser Doppler vibrometer (LDV). To avoid limitations posed by the optical resolution of the LDV, we leverage a manufacturing process to create ultra-large graphene drums with diameters of up to 1000 μm. We solve the inverse problem of a Föppl–von Kármán plate model by an iterative procedure to obtain the stress distribution within the drums from the experimental data. Our results show that the generally used uniform pre-tension assumption overestimates the pre-stress value, exceeding the averaged stress obtained by more than 47%. Moreover, it is found that the reconstructed stress distributions are bi-axial, which likely originates from the transfer process. The introduced methodology allows one to estimate the tension distribution in drum resonators from their mechanical response and thereby paves the way for linking the used fabrication processes to the resulting device performance.
Abundant electric-field tunable symmetry-broken states in twisted monolayer-bilayer graphene
Authors: Peng Huimin , Zhong Jinrui , Feng Qi , Hu Yuqing , Li Qiuli , Zhang Shihao , Mao Jinhai , Duan Junxi , Yao Yugui 
Published: July 2024

AbstractElectron-electron correlations can lift the high degeneracies in strong correlated systems, resulting in various symmetry-broken states. Twisted monolayer-bilayer graphene (tMBG) is an especially rich system due to its low crystalline symmetry. Here, we report abundant electric-field tunable symmetry-broken states in tMBG. The ground state at half filling of the conduction flat band is spin- and valley-polarization dominated under positive and negative electric field, respectively, consistent with our theoretical calculations. In addition, we find a symmetry-broken Chern insulator emanating from 1.5 electrons per moiré unit with C = 3 emerges at high magnetic field in a negative electric field range. The C = 3 suggests that one and a half flavor-polarized Chern 2 bands within the same valley are filled, consistent with the valley-polarization-dominated half-filling state under negative electric field, while the fractional filling stems from a density-wave state held by enlarged unit cells containing two moiré units.
Realistic morphology-preserving generative modelling of the brain
Authors: Tudosiu Petru-Daniel , Pinaya Walter H. L. , Ferreira Da Costa Pedro , Dafflon Jessica , Patel Ashay , Borges Pedro , Fernandez Virginia , Graham Mark S. , Gray Robert J. , Nachev Parashkev , Ourselin Sebastien , Cardoso M. Jorge 
Published: July 2024

AbstractMedical imaging research is often limited by data scarcity and availability. Governance, privacy concerns and the cost of acquisition all restrict access to medical imaging data, which, compounded by the data-hungry nature of deep learning algorithms, limits progress in the field of healthcare AI. Generative models have recently been used to synthesize photorealistic natural images, presenting a potential solution to the data scarcity problem. But are current generative models synthesizing morphologically correct samples? In this work we present a three-dimensional generative model of the human brain that is trained at the necessary scale to generate diverse, realistic-looking, high-resolution and morphologically preserving samples and conditioned on patient characteristics (for example, age and pathology). We show that the synthetic samples generated by the model preserve biological and disease phenotypes and are realistic enough to permit use downstream in well-established image analysis tools. While the proposed model has broad future applicability, such as anomaly detection and learning under limited data, its generative capabilities can be used to directly mitigate data scarcity, limited data availability and algorithmic fairness.
Complex interplay between RAS GTPases and RASSF effectors regulates subcellular localization of YAP
Authors: Singh Swati , Bernal Astrain Gabriela , Hincapie Ana Maria , Goudreault Marilyn , Smith Matthew J 
Published: July 2024

AbstractRAS GTPases bind effectors to convert upstream cues to changes in cellular function. Effectors of classical H/K/NRAS are defined by RBD/RA domains which recognize the GTP-bound conformation of these GTPases, yet the specificity of RBD/RAs for over 160 RAS superfamily proteins remains poorly explored. We have systematically mapped interactions between BRAF and four RASSF effectors, the largest family of RA-containing proteins, with all RAS, RHO and ARF small GTPases. 39 validated complexes reveal plasticity in RASSF binding, while BRAF demonstrates tight specificity for classical H/K/NRAS. Complex between RASSF5 and diverse RAS GTPases at the plasma membrane can activate Hippo signalling and sequester YAP in the cytosol. RASSF8 undergoes liquid-liquid phase separation and resides in YAP-associated membraneless condensates, which also engage several RAS and RHO GTPases. The poorly studied RASSF3 has been identified as a first potential effector of mitochondrial MIRO proteins, and its co-expression with these GTPases impacts mitochondria and peroxisome distribution. These data reveal the complex nature of GTPase-effector interactions and show their systematic elucidation can reveal completely novel and biologically relevant cellular processes.
In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection
Authors: Chen Xingjuan , Yan Yunzheng , Liu Zhiqiang , Yang Shaokang , Li Wei , Wang Zhuang , Wang Mengyuan , Guo Juan , Li Zhenyang , Zhu Weiyan , Yang Jingjing , Yin Jiye , Dai Qingsong , Li Yuexiang , Wang Cui , Zhao Lei , Yang Xiaotong , Guo Xiaojia , Leng Ling , Xu Jiaxi , Obukhov Alexander G , Cao Ruiyuan , Zhong Wu 
Published: July 2024

AbstractZika virus (ZIKV) infection may lead to severe neurological consequences, including seizures, and early infancy death. However, the involved mechanisms are still largely unknown. TRPC channels play an important role in regulating nervous system excitability and are implicated in seizure development. We investigated whether TRPCs might be involved in the pathogenesis of ZIKV infection. We found that ZIKV infection increases TRPC4 expression in host cells via the interaction between the ZIKV-NS3 protein and CaMKII, enhancing TRPC4-mediated calcium influx. Pharmacological inhibition of CaMKII decreased both pCREB and TRPC4 protein levels, whereas the suppression of either TRPC4 or CaMKII improved the survival rate of ZIKV-infected cells and reduced viral protein production, likely by impeding the replication phase of the viral life cycle. TRPC4 or CaMKII inhibitors also reduced seizures and increased the survival of ZIKV-infected neonatal mice and blocked the spread of ZIKV in brain organoids derived from human-induced pluripotent stem cells. These findings suggest that targeting CaMKII or TRPC4 may offer a promising approach for developing novel anti-ZIKV therapies, capable of preventing ZIKV-associated seizures and death.
In situ XPS study of methanol oxidation over a copper catalyst derived from layered double hydroxides
Authors: Panafidin Maxim A. , Bukhtiyarov Andrey V. , Fedorov Alexey Yu. , Bukhtiyarova Marina V. , Prosvirin Igor P. , Bukhtiyarov Valerii I. 
Published: July 2024

Copper nanoparticles supported on alumina have been synthesized from CuAl-layered double hydroxide and have been studied in methanol oxidation at different molar ratios of the components of the reaction feed by in situ XPS and mass-spectrometry.
Impact of translator mass and buoy choice on a power absorption of point absorbing wave energy converter linear generator with linear generator power take off
Authors: Potapenko Tatiana , Boström Cecilia , Temiz Irina 
Published: July 2024

AbstractOcean waves have the potential to contribute to future renewable electricity production. A wave energy converter (WEC) is a technology developed to absorb the energy of the wave and convert it to another form of energy. The Uppsala University WEC (UU WEC) is a point absorber with a direct drive permanent magnet synchronous linear generator power take off. Among other parameters affecting the value of absorbed power for UU WEC are the buoy size, mass of the system consisting of the buoy and translator, and available wave energy at the site of interest. This study reviews the earlier static model that considered only static forces as the buoyancy and gravity forces and neglected all dynamic forces. The static model was proposed to simplify the early‐stage design decision. Although the static model was applied to two UU WECs of different dimensions, the present study shows that the static model is not held for certain buoy and translator dimensions. As an alternative, the dynamic model which accounts for the impact of hydrodynamic forces and various translator masses is proposed. The dynamic model is based on Cummins' equation and the linear potential flow theory, and the damping force is approximated as a viscous damper with the constant damping coefficient optimizing the absorbed mechanical power under a particular sea condition. The dynamic model is applied to four fixed buoy geometries of two shapes (cylinder and cylinder with a moonpool), each of two different dimensions, but the method can be extended to other buoy shapes and dimensions. In addition, the impact of translator mass was assessed for two sites located on the west coast of Sweden and near Gran Canaria, Spain. A translator of 10–11 t promotes 16.8% higher annual average power absorption for a cylindrical buoy compared to a translator of 6 t for the same buoy. However, heavier translators up to 15 t provide only 1.1% increase in average annual absorbed power.
Maladie de Sjögren : de la physiopathologie aux avancées thérapeutiques
Authors: Mariette Xavier 
Published: July 2024

La maladie de Sjögren (SjD) est une maladie auto-immune systémique caractérisée par une triade de symptômes clés affectant presque tous les patients (sécheresse salivaire et lacrymale, douleur et fatigue) et une atteinte systémique extra-glandulaire pouvant toucher un à deux tiers des patients. Au cours de la dernière décennie, les connaissances sur l’épidémiologie, les critères de classification, l’évaluation de l’activité systémique et des symptômes présentés par les patients se sont développés. En outre, les progrès réalisés dans la compréhension de la physiopathologie du SjD ont permis d’adopter une approche thérapeutique plus ciblée. La prise en charge actuelle du SjD s’appuie sur les recommandations thérapeutiques de l’EULAR. Mais depuis ces recommandations, de nouveaux médicaments ciblant des voies physiopathologiques spécifiques de la maladie, et essentiellement l’activation du lymphocyte B, ont montré une efficacité dans des essais de phase 2. Dans cette revue, nous résumerons les données factuelles disponibles sur les traitements systémiques, y compris : 1. les progrès dans l’évaluation des résultats, 2. les preuves actuelles concernant les traitements de fond ciblés et les biomédicaments ciblant essentiellement les lymphocytes B, 3. une vue d’ensemble des médicaments prometteurs testés dans les études en cours.
Monitoring the Breath-Hold Training Load during an Ecological
Session: A Pilot Study
Authors: Allinger Jérémie , Bouyeure Antoine , Noulhiane Marion , Lemaitre Frederic 
Published: July 2024

AbstractThis study aimed to create a training load index to measure physiological stress
during breath-hold (BH) training and examine its relationship with memory
performance. Eighteen well-trained BH divers (Age: 35.8±6.6 years, BH training
practice: 5.3±4.5 years) participated in this study. During a standard 1.5-hour
BH training in the pool, perceived exertion, heart rate, distance, and duration
were measured. The training load index was modelled on the basis of a TRIMP
(TRaining IMPulse) with four different equations and was used to measure the
stress induced by this BH training. A reference value, based on the ratio
between the average heart rate during all BHs and the lowest heart rate during
BH training, was used for comparing training load index. Memory assessment was
conducted both before and after this training. Of the four equations proposed,
equation no. 4, named aTRIMP for “apnoea,” showed the strongest correlation with
our reference value (r=0.652, p<0.01). No difference was found between any of
the memory tests before and after the BH training. The aTRIMP was a new
representative index for monitoring habitual training of well-trained BH divers.
Furthermore, this training had no negative impact on memory performance.
Timing of Off-Label Dosing of Direct Oral Anticoagulants in Three Large Health Systems
Authors: Herron Grace C. , DeCamillo Deborah , Kong Xiaowen , Haymart Brian , Kaatz Scott , Ellsworth Stacy , Ali Mona A. , Giuliano Christopher , Froehlich James B. , Barnes Geoffrey D. 
Published: July 2024

Background While direct oral anticoagulants (DOACs) may be viewed as simpler to manage then warfarin, they present their own unique management challenges resulting in frequent off-label dosing. It is unknown to what extent off-label dosing occurs when a patient is started on a DOAC versus later in their treatment.
Objectives We aimed to better characterize when off-label DOAC dosing is occurring and to evaluate the effectiveness of prescribing oversight using a registry-based intervention.
Methods We evaluated data from the Michigan Anticoagulation Quality Improvement Initiative (MAQI2) registry, a retrospective quality-improvement process using data abstractors, from 2018 to 2022 on the number of “alerts” that are generated in response to dosing deviating from the U.S. Food and Drug Administration instructions for atrial fibrillation (AF) and venous thromboembolism (VTE).
Results Among a sample of 789 to 1,022 annual AF patients and 381 to 484 annual VTE patients prescribed a DOAC in the MAQI2 registry, off-label dosing was relatively common. Over the 5-year period (2018–2022), there were 569 alerts for AF patients and 162 alerts for VTE patients. Alerts occurred more frequently during follow-up than at the time of initial prescribing in AF patients (78.2 vs. 21.8%), but more commonly at initial prescribing in VTE patients (59.9 vs. 40.1%). After initial review by quality-improvement abstractors, 19.3% of AF alerts and 14.8% of VTE alerts resulted in contact to the prescriber. When the prescriber was contacted, it led to an intervention about 75% of the time for both populations. The most common intervention was a change in DOAC dosing.
Conclusion This study demonstrates the benefit of DOAC prescribing oversight using a registry-based intervention to monitor for off-label dosing for the entirety of the time period a patient is prescribed DOAC, particularly for patients with AF, as off-label prescribing occurs frequently during the follow-up period.
Developing an Interventional Radiology Service
Authors: Nguyen Luan D. 
Published: July 2024

AbstractInterventional radiology (IR) is a rapidly developing field among medical activities. This review summarizes the history of IR since the inception of angiography, the present situation regarding IR's position in the clinical setting, and proposal of standardized education and further cooperation in the field. This review also focuses on sharing the author's experience in establishing an extensive IR service line, and how this will become the standard model for the Vietnamese Society of Interventional Radiology.
Ultrafast photochemistry and electron diffraction for cyclobutanone in the S2 state: Surface hopping with time-dependent density functional theory
Authors: Miller Ericka Roy , Hoehn Sean J. , Kumar Abhijith , Jiang Dehua , Parker Shane M. 
Published: July 2024

We simulate the photodynamics of gas-phase cyclobutanone excited to the S2 state using fewest switches surface hopping (FSSH) dynamics powered by time-dependent density functional theory (TDDFT). We predict a total photoproduct yield of 8%, with a C3:C2 product ratio of 0 trajectories to 8 trajectories. One primary S2 → S1 conical intersection is identified involving the compression of an α-carbon–carbon–hydrogen bond angle. Excited state lifetimes computed with respect to electronic state populations were found to be 3.96 ps (S2 → S1) and 498 fs (S1 → S0). We also generate time-resolved difference pair distribution functions (ΔPDFs) from our TDDFT-FSSH dynamics results in order to generate direct comparisons with ultrafast electron diffraction experiment observables. Global and target analysis of time-resolved ΔPDFs produced a distinct set of lifetimes: (i) a 0.548 ps decay and (ii) a 1.69 ps decay, both resembling the S2 minimum, as well as (iii) a long decay that resembles the S1 minimum geometry and the fully separated C2 products. Finally, we contextualize our results by considering the impact of the most likely sources of significant errors.
Screened optimally tuned range separated hybrid functional for solvated low bandgap molecular systems
Authors: Dantas Filho Reinaldo V. , de Queiroz Thiago B. 
Published: July 2024

The description of electronic properties of low bandgap molecular system is often performed by using density functional theory (DFT) and time dependent (TD) DFT calculations with the optimally tuned range-separated hybrid (OT-RSH) functional, as it contains the necessary ingredients to reliably predict charge transfer excitations. However, the range separating parameter (ω) is system-dependent and its optimization, including the chemical environment, is intricate. Refaely-Abramson et al. demonstrated that the gap renormalization in molecular crystals, a ground state property, can be represented by an OT-RSH functional screened by ɛstatic [Phys. Rev. B 88, 081204(R) (2013)], the zero frequency scalar dielectric constant. In this study, we propose the use of an OT-RSH functional screened by the scalar dielectric constant in the high frequency limit (OT-sRSH), ɛ∞, an appropriate constraint for vertical ionization energies or excitations in a dielectric environment. We have performed calculations for S,N-heteroacene derivatives in tetrahydrofuran and dichloromethane. The “unscreened” OT-RSH functional tends to underestimate experimental ionization potentials (IPs) and optical gaps (Egs) by up to 1.5 and 0.5 eV, respectively. In contrast, OT-sRSH functional calculations underestimate IPs and Egs by only 0.4 and 0.2 eV. We also compared the OT-sRSH results to explicitly solvated OT-RSH functional calculations for oligothiophenes in dioxane, benzene in ammonia, and methylene blue in water. We observe that both the approaches perform similarly for weakly interacting intermolecular systems and deviate for solvent–solute interacting systems, as expected. In conclusion, the OT-sRSH functional can describe molecular systems with environmental polarization effects accurately, a step toward describing realistic molecular systems.
A modular, high dynamic range passive neutron dosimeter and imaging diagnostic
Authors: Schmidt T. R. , Dwyer R. H. , Broughton D. P. , Hochanadel M. P. , Batha S. H. 
Published: July 2024

The multi-decade neutron dosimeter and imaging diagnostic (MDND) is a passive diagnostic that utilizes the polyethylene (n, p) nuclear reaction to enhance the diagnostic’s sensitivity for time and energy integrated neutron measurements in the range of 2.45–14.1 MeV. The MDND utilizes a combination of radiochromic film, phosphor image plates, and solid-state nuclear track detectors, with the goal of providing several orders of magnitude of dynamic range in terms of measured neutron fluence. The diagnostic design was guided by simulations in the Monte Carlo N-Particle (MCNP) transport code to determine the optimum thickness of the polyethylene convertor for maximum proton fluence incident on the detection medium as a function of incident neutron energy. In addition, the simulation results of complete diagnostic assemblies, or “stacks,” were used to determine the total dynamic range of an MDND in terms of measured neutron source yield, which was found to be between around 107 and 1015 emitted into 4π with the detector located 1 m away from the source. Complimentary to these simulations, individual detectors within a stack were simulated and analyzed to determine response as a function of neutron energy and yield. This work presents the diagnostic design, MCNP simulation results, and analysis of expected signals for varying neutron sources.
WITHDRAWN: Crossover from relativistic to non-relativistic net magnetization for MnTe altermagnet candidate
Authors: Orlova N. N. , Avakyants A. A. , Timonina A. V. , Kolesnikov N. N. , Deviatov E. V. 
Published: July 2024

Notice of Withdrawal
This paper was withdrawn by IOP Publishing on 30/08/2024. This paper was published due to an error. The authors are free to publish this work elsewhere. IOP Publishing apologise for this error.
Strong Cosmic Censorship with bounded curvature
Authors: Reintjes Moritz 
Published: July 2024

Abstract
In this paper we propose a weaker version of Penrose’s much heeded Strong Cosmic Censorship (SCC) conjecture, asserting inextendability of maximal Cauchy developments by manifolds with Lipschitz continuous Lorentzian metrics and Riemann curvature bounded in Lp
. Lipschitz continuity is the threshold regularity for causal structures, while curvature bounds rule out infinite tidal accelerations, arguing for physical significance of this weaker SCC conjecture. The main result of this paper, under the assumption that no extensions exist with higher connection regularity

W
loc

1
,
p

, proves in the affirmative this SCC conjecture with bounded curvature for p sufficiently large, (p > 4 to address uniform bounds, p > 2 without uniform bounds).