bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between TEX14 and ADAM17 expressions in colorectal cancer tissues of elderly patients and neoplasm staging, invasion, and metastasis
Authors: Chen Gun , Cong Ling-Hua , Gu Chi-Jiang , Li Ping 
Published: July 2024

BACKGROUND
Colorectal cancer (CRC) is one of the most frequently encountered malignant tumors in clinical settings. Proteins encoded by the testis-expressed gene 14 (TEX14) are imperative for spermatogenesis, necessitating intercellular bridges between germ cells. Anomalous expression of TEX14 has also been associated with the proliferation and differentiation of certain tumor cells. Recombinant A disintegrin and metalloprotease 17 (ADAM17) is known as a membrane-bound protease that regulates cellular activities and signal transduction by hydrolyzing various substrate proteins on the cell membrane. We hypothesize that TEX14 and ADAM17 may serve as potential biomarkers influencing the staging, invasion, and metastasis of CRC.
AIM
To probe the correlation between TEX17 and ADAM17 profiles in the CRC tissues of elderly patients and their association with CRC staging, invasion, and metastasis.
METHODS
We gathered data from 86 elderly patients diagnosed pathologically with CRC between April 2020 and December 2023. For each patient, one sample of cancer tissue and one sample of adjacent normal tissue were harvested. Real-time fluorescence quantitative PCR measured the mRNA profiles of TEX14 and ADAM17. Immunohistochemistry ascertained the positivity rates of TEX14 and ADAM17 expressions. Clinical pathological features of neoplasm staging, invasion, and metastasis were collected, and the association between TEX14 and ADAM17 expressions and clinical pathology was evaluated.
RESULTS
The mRNA and expression profiles of TEX14 and ADAM17 were significantly elevated in CRC tissues. The positivity rates of TEX14 and ADAM17 proteins in CRC tissues were 70.93% and 77.91%, respectively. There were no significant differences in age, sex, pathological type, and tumor diameter between TEX14 and ADAM17-positive and -negative patients. Patients with higher tumor differentiation degree, deeper infiltration and TNM stages ranging from III to IV exhibited higher positivity rates of TEX14 and ADAM17. Patients with lymph node metastasis and distant metastasis showed higher positivity rates of TEX14 and ADAM17 than those without. Positive expressions of TEX14 and ADAM17 were highly correlated with tumor staging, invasion, and metastasis.
CONCLUSION
TEX14 and ADAM17 profiles were significantly elevated in the CRC tissues of elderly patients, and their high expressions were associated with tumor staging, invasion, and metastasis.
IgG4-related sclerosing cholangitis associated with essential thrombocythemia: A case report
Authors: Wu Zhi-Nian , JI Ru , Xiao Ying , Wang Ya-Dong , Zhao Cai-Yan 
Published: July 2024

BACKGROUND
The complexity of immunoglobulin G4 (IgG4)-related diseases and their potential connection to hematologic malignancies remains unclear. This article provided a review of the diagnosis and treatment of a patient with IgG4-related sclerosing cholangitis (SC) and essential thrombocythemia (ET), along with an analysis of relevant literature to enhance comprehension of this disease.
CASE SUMMARY
A 56-year-old male was admitted to two hospitals with deteriorating jaundice and pruritus prior to hospitalization. Beyond our expectations, the patient was first diagnosed with IgG4-SC and ET with the Janus kinase 2 V617F mutation. Interestingly, the administration of acetate prednisone significantly resulted in improvements in both IgG4-SC and ET. Clinicians need to pay attention to immune disorders and inflammation as they contribute to the development of various disease phenotypes.
CONCLUSION
When IgG4-SC is suspected without histopathological evidence, diagnostic therapy and long-term regular follow-up can lead to positive treatment outcomes. Clinicians should be mindful of the potential presence of concurrent hematologic diseases in patients with immune disorders.
Ultrahigh Q SOI ring resonator with a Hermite or B-spline curved waveguide
Authors: Tao Pengyu , Yan Boxia , Bai Mou , Zhou Mi , Sun Chenxi , Qi Yan , Wang Yanwei , Han Zhe , Fan Yuanyuan , Wang Qian 
Published: July 2024

Two new, to the best of our knowledge, designs for a huge, single-mode operation, ultrahigh quality factor SOI ring resonators based on the 90° bend of the B-spline curve and the Hermite curve were demonstrated. The ring resonators comprise multimode straight strip waveguides (MMWG), single-mode strip waveguides (SMWG), 90° bends, and tapers. The TE0-TE0 transmission loss of the bends can reach 0.000013 dB and 0.000091 dB, and the TE0-TE1 excitation ratios reach −48dB and −50dB, respectively, when the bends were designed using the Hermite curve or B-spline curve. Two SOI ring resonators of about 3.00 cm length consisting of the structures mentioned above are manufactured. The first was made up of Hermite curves with 90° bends. It could achieve a Q factor of 4.65×106 and a free spectrum range (FSR) of 0.025 nm. The second one employed B-spline curves with 90° bends. It could reach a Q factor of 4.37×106 and FSR of 0.022 nm.
Optimized designs for micropillar cavity with simultaneously high quality factor and Gaussian far field at near-wavelength diameter
Authors: Wang Jiajun , Wu Bang , Yuan Zhiliang 
Published: July 2024

Micropillar cavities with small volumes and high quality factors (Q-factor) greatly enhance the light-matter interaction. Crucially, these cavities exhibit a near-Gaussian far-field pattern, making them highly suitable for efficiently coupling and manipulation of emitted photons. However, their miniaturization into near-wavelength scales is limited by diffraction, resulting in both Q-factor degradation and far-field emission divergence. Here, we propose a tapered micropillar cavity design that simultaneously achieves a high Q-factor (Q = 1.37 × 105) and near-Gaussian far-field emission at near-wavelength diameter (mode volume V
m
= 0.154λ3). Notably, its direct single-mode fiber coupling efficiency is 0.71, representing a remarkable 230 % improvement compared to traditional λ-micropillar cavities of the same diameter. Our results show prospects of ideal fiber-coupled platforms for cavity quantum electrodynamics experiments, particularly in the strong coupling regime.
Energy Efficient Multicore Fiber Amplifiers
Authors: Jung Yong-min , Liang Sijing , Downie John , Makovejs Sergejs , Edwards Merrion , Petropoulos Periklis 
Published: July 2024

Energy-efficient multicore fiber (MCF) amplifiers are crucial for establishing future high-capacity submarine transmission systems. This paper reviews recent advancements and explores future directions in MCF amplifier development, highlighting their potential for cost-effective and power-efficient operation.
Full-text article not available; see video presentation
An Operator’s View on the Future Optical Networks, and Enabling Device Technologies: ~Innovative Optical and Wireless Network Program~
Authors: Tomizawa Masahito 
Published: July 2024

In this presentation, future vision of optical networks is discussed from the viewpoint of service requirements from operators, demanding higher capacity & quality, and lower latency & power consumption. Also enabling device technologies are introduced, where photonics and electronics convergence (PEC) is focused. This presentation is in conjunction with Innovative Optical and Wireless Networks (IOWN) program.
Full-text article not available; see video presentation
Silicon-Organic Hybrid (SOH) Integration - From Lab to Fab
Authors: Koos Christian , Freude Wolfgang , Randel Sebastian , Bräse Stefan , Erk Peter , Eschenbaum Carsten , Kuzmin Artem , Mertens Adrian , Schwarzenberger Adrian , Kholeif Hend , Kotz Alexander , Sarwar Sidra , Singer Stefan 
Published: July 2024

Silicon-organic hybrid (SOH) integration can complement intrinsically scalable silicon photonic circuits by novel functionalities, obtained through theory-guided material engineering. This presentation will give an overview of our recent progress in exploring the potential of the SOH platform and in bringing the technology from laboratory demonstrations to industrial applications.
Full-text article not available; see video presentation
"Tight Sync" in Precision Time Protocol (PTP), Requirements and Impact at Optical Component Level
Authors: Ruffini Stefano , McKeown Shane 
Published: July 2024

Accurate time sync is required by various applications (e.g., 5G). This talk will go through the challenges in distributing accurate timing, including the impact to performance from some optical technologies, and options to verify performance of optical modules.
Full-text article not available; see video presentation
Subwavelength Photonic Structures for Nonlinear Optical Functionalities
Authors: Nuño Ruano Paula , Zhang Jianhao , González-Andrade David , Ferhart Hiba El Batoul , Dinh Thi Thuy Duong , Medina Quiroz David , Cheben Pavel , Marris-Morini Delphine , Cassan Eric , Vivien Laurent , Lanzillotti-Kimura Norberto Daniel , Alonso Ramos Carlos 
Published: July 2024

Periodic subwavelength patterning of silicon enables the control of nonlinear effects with unprecedented flexibility. Here, we will present our most recent results on nonlinear supercontinuum generation and nonlinear Brillouin interactions in subwavelength silicon waveguides.
Full-text article not available; see video presentation
Association between HTLV-1/2 infection and COVID-19 severity in a migrant Shipibo-Konibo population in Lima, Peru
Authors: Avila Dextre Fátima , Morales Álvarez Bryan , Aguirre Castañeda Paulo , Alva Isaac Efrain , López Giovanni , Schwalb Alvaro , Gotuzzo Eduardo 
Published: July 2024

Objectives
The migrant community of the Shipibo-Konibo indigenous people in Lima, Peru were extremely vulnerable during the COVID-19 pandemic. Additionally, infection with human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in this population causing immunosuppression. The aim of the study was to describe the association between HTLV-1/2 infection and the clinical severity of COVID-19.

Methods
This was a cross-sectional descriptive study involving a survey of adult Shipibo-Konibo indigenous migrants residing in Cantagallo-Rímac who were identified as suspected or confirmed cases of COVID-19. Blood samples were collected for SARS-CoV-2 antibody and HTLV-1/2 ELISA testing. A confirmatory Western Blot test was performed for those with a positive ELISA test.

Results
A total of 182 individuals were surveyed and sampled. No significant association was found between HTLV-1/2 infection and the clinical severity of COVID-19. The prevalence of HTLV-1/2 was 8.8% (95%CI: 5.0–14.1) with Western Blot. Age was the only statistically significant risk factor for developing a more severe form of COVID-19 (OR: 1.03; 95%CI: 1.00–1.06; p = 0.032).

Conclusions
There was no association found between HTLV-1/2 infection and the clinical severity of COVID-19. The prevalence of HTLV-1/2 infection in the Shipibo-Konibo population is high and warrants continuous monitoring in the advent of other infectious disease outbreaks and the development of HTLV-associated comorbidities.
Psychological distress and its associated factors among people with specific chronic conditions (diabetes and/or hypertension) in the Sidama region of southern Ethiopia: A cross-sectional study
Authors: Borie Yacob Abraham , Tamiso Alemu , Gutema Keneni , Jisso Meskerem , Deribe Bedilu , Fikre Rekiku , Defar Semira , Ayalew Mohammed , Abera Wondwossen 
Published: July 2024

Background
The majority of people with long-term, non-communicable medical conditions experience significant psychological anguish. Poor mental health or psychological distress influences low lifestyle decisions that result in obesity, inactivity, and cigarette use as well as poor health literacy and limited access to health promotion activities.

Objectives
The study’s purpose was to measure the prevalence of psychological distress and it’s predictors in patients with chronic non-communicable diseases who were being treated in selected hospitals in the Sidama region of southern Ethiopia in 2022.

Methodology
Institutional based cross-sectional study was carried out using a sample of 844 patients receiving medication for either high blood pressure or diabetes mellitus or both between May1 and August 31, 2022. To gauge psychiatric distress, the Amharic translation and Ethiopian validation of the Kessler 6 scale (K-6) was employed. The analysis was done using binary logistic regression and an odds ratio with the corresponding 95% confidence interval was estimated to measure the strength of the association. P value <0.05 was considered to declare the significance.

Result
Patients with diabetic mellitus, hypertension or both had a 49.6% prevalence of psychological distress at selected Sidama hospitals. Age, drug side effects, history medical complications following diabetic mellitus/hypertension, and body mass index of the patient were all significantly linked with psychological distress (P<0.05).

Conclusion
According to the results of this study, psychological distress is far more prevalent than it was in past studies in Ethiopia and other African countries. To lessen the problem, all stakeholders must cooperate, but health agencies, policymakers, and NGOs particularly need to put in extra effort. The study also showed a significant association between body mass index, patient age, drug side effects, and history of medical complications following diabetic mellitus /hypertension.
Distortions to the passage of time for annual events: Exploring why Christmas and Ramadan feel like they come around more quickly each year
Authors: Ogden Ruth , Alatrany Saad S. J. , Flaiyah Ashraf Muwafaq , ALi Sayyid ALdrraji Hasan , Musa Hanan , Alatrany Abbas S. S. , Al-Jumeily Dhiya 
Published: July 2024

Background
Commonly heard statements such as “Christmas comes around more quickly each year” suggest that the passage of time between annual events can become distorted, leading to the sensation of time passing more quickly than normal. At present however, it is unclear how prevalent such beliefs are and, what factors are predictive of it.

Aim
To explore the prevalence of beliefs that annual events such as Christmas (Study 1 UK sample) and Ramadan (Study 2 Iraqi sample) feel like they come around more quickly each year. To establish the association between distortions to the passage of time between annual events and emotional wellbeing, event specific enjoyment, memory function and self-reported attention to time.

Methods
Participants completed an online questionnaire exploring their subjective experience of time in relation to Christmas and Ramadan. In addition, measures of attention to time, memory function, quality of life and event specific emotion were also taken.

Findings
There was widespread agreement that Christmas and Ramadan appeared to come around more quickly each year. In both countries, this belief was associated with greater prospective memory errors, greater attention to time and greater enjoyment of the event. Furthermore, in the UK greater belief that Christmas comes around more quickly was associated with lower social quality of life and in Iraq, greater belief that Ramadan comes around more quickly each year was associated with lower age and female gender.

Conclusions
Distortions to the passage of time for annual events are widespread, occur across multiple cultures and are consistently predicted by prospective function, event enjoyment and attention to time. The absence of an association between older age (above 55 years) and a faster passage of time suggests that caution should be taken when concluding that time passes more quickly with increasing age.
Compassionate care through the eyes of patients and physicians: An interview study
Authors: Debets Maarten P. M. , Jansen Iris , Diepeveen Mariëlle , Bogerd Rosa , Molewijk Bert A. C. , Widdershoven Guy A. M. , Lombarts Kiki M. J. M. H. 
Published: July 2024

Background
Although compassion is a crucial element of physicians’ professional performance and high-quality care, research shows it often remains an unmet need of patients. Understanding patients’ and physicians’ perspectives on compassionate care may provide insights that can be used to foster physicians’ ability to respond to patients’ compassion needs. Therefore, this study aims to understand how both patients and physicians experience the concept and practice of compassionate care.

Methods
We conducted semi-structured interviews with eight patients and ten resident physicians at a University Medical Center in the Netherlands. Using thematic analysis, we separately coded patient and resident transcripts to identify themes capturing their experiences of compassionate care. This study was part of a larger project to develop an educational intervention to improve compassion in residents.

Results
For both patients and residents, we identified four themes encompassing compassionate care: being there, empathizing, actions to relieve patients’ suffering, and connection. For residents, a fifth theme was professional fulfillment (resulting from compassionate care). Although patients and residents both emphasized the importance of compassionate care, patients did not always perceive the physician-patient encounter as compassionate. According to residents, high workloads and time pressures hindered their ability to provide compassionate care.

Discussion and conclusion
Patients and residents have similar and varying understandings of compassionate care at the same time. Understanding these differences can aid compassion in medical practice. Based on the findings, three topics are suggested to improve compassion in residents: (1) train residents how to ask for patients’ compassion needs, (2) address residents’ limiting beliefs about the concept and practice of compassion, and (3) acknowledge the art and science of medicine cannot be separated.
The role of social media on COVID-19 preventive behaviors worldwide, systematic review
Authors: Talie Fenta Eneyew , Bogale Eyob Ketema , Anagaw Tadele Fentabel 
Published: July 2024

Background
The likelihood of COVID-19 spreading from one individual to another is impacted by personal factors, preventive actions taken, and the quantity and length of exposure. Social media instantly shares health information with the public so medical professionals can interact with them.

Methods
The review used Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. We retrieve articles by using keywords on Pub Med, Cochrane Library, and grey literatures. The Joanna Briggs Institute (JBI) Meta-Analysis of Statistics Assessment and Review Instrument was used to check the quality of articles. The main qualitative synthesis was including comments related to the characteristics of the studied populations, the study period, and the main results obtained from the social media platforms.

Result
This study includes 32 studies conducted in 20 countries globally. Most of the studies discussed that during the pandemics different types of social medias were utilized to provide knowledge to change the attitude of the people and helps to practices COVID-19 preventive behaviors. By enabling people to seek and share knowledge, socialize, and find pleasure, social media use encourages people to adopt preventive behaviors. This review demonstrated a substantial relationship between higher levels of precautionary behaviors and factors such as educational status, knowledge, fear, and reading medical pages on social media. According to the studies, watching videos is a reliable means to get accurate information, and watching animated films posted on social media can help people learn more about COVID-19 preventive strategies.

Conclusion
In these urgent times, social media could even help with quick information availability; misinformation or inadequate understanding can cause misunderstandings within the community. This analysis revealed that following medical pages on social media, having knowledge, feeling afraid, and having an educational background were all strongly correlated with greater levels of aware preventive behavior. Therefore, it is advised for policy makers to develop social behavioral change health communication strategies, guidelines on COVID-19 prevention behaviors. Health care providers should prepare health learning materials, and provide accurate, updated and timely information using all forms of social media to correct mis- information, misperceptions, depression, and anxiety for better control of the pandemics. Future research shall focus on evaluating effectiveness of each social media platform interventions during such emergency crisis.
Exposure to second-hand smoke and risk of lung cancer among Iranian population: A multicenter case-control study
Authors: Lotfi Fereshte , Rashidian Hamideh , Hadji Maryam , Mohebbi Elham , Marzban Maryam , Naghibzadeh-Tahami Ahmad , Pukkala Eero , Boffetta Paolo , Etemadi Arash , Zendehdel Kazem 
Published: July 2024

Objective
Despite the implementation of the WHO Framework Convention on Tobacco Control (FCTC) program in Iran, the regulation of second-hand smoke (SHS) exposure—an often-overlooked hazard—, still requires improvement. We employed a multi-center case-control study to investigate the association between exposure to secondhand smoke (SHS) from various tobacco products (cigarettes, water-pipes, pipes, and chopogh), opium use, and the risk of lung cancer.

Method
We included 627 lung cancer cases and 3477 controls. Exposure to SHS tobacco and SHS opium was collected through a questionnaire. We used mixed-model logistic regressions to estimate odds ratios (ORs) and 95% confidence intervals (CI).

Result
Among the overall population exposed to second-hand tobacco smoke (SHTS), the odds ratio (OR) compared to those never exposed was 1.35 (95% CI: 1.08–1.71). Never smokers who were ever exposed to second-hand tobacco smoke (SHTS) had 1.69-fold risk of lung cancer compared to those who were never exposed (95% CI: 1.13–2.52). Exposure to SHTS between 2–3 per day (OR = 2.27, 95% CI: 1.13–4.53) and more than three hours per day (OR = 2.29, 95% CI: 1.20–4.37) can increase the risk of lung cancer compared with the no exposure group (P-trend <0.01). We did not observe any association between exposure to second-hand opium smoke (SHOS) and the risk of lung cancer, either in the overall population or among never-smokers.

Conclusion
Our study estimates the impact of second-hand tobacco smoke (SHTS) on lung cancer risk in both the overall population and never-smokers. Additional studies are required to evaluate the association between exposure to second-hand smoke from opium and other type of tobacco, including water-pipe and the risk of lung cancer.