bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unrecognised COVID-19 deaths in central Europe: The importance of cause-of-death certification for the COVID-19 burden assessment
Authors: Fihel Agnieszka , Janicka Anna , Buschner Andrea , Ustinavičienė Rūta , Trakienė Aurelija 
Published: July 2024

Objective
In Central Europe, the increase in mortality during the COVID-19 pandemic exceeded the number of deaths registered due to coronavirus disease. Excess deaths reported to causes other than COVID-19 may have been due to unrecognised coronavirus disease, the interruptions in care in the overwhelmed health care facilities, or socioeconomic effects of the pandemic and lockdowns. Death certificates provide exhaustive medical information, allowing us to assess the extent of unrecognised COVID-19 deaths.

Materials and methods
Data from 187,300 death certificates with a COVID-19 mention from Austria, Bavaria (Germany), Czechia, Lithuania and Poland, 2020–2021, was used. The two step analysis uses Cause of Death Association Indicators (CDAIs) and Contributing CDAIs to identify and measure the statistical strength of associations between COVID-19 and all other medical mentions.

Results
15,700 deaths were reported with COVID-19 only as a contributing condition (comorbidity). In three cases out of four, a typical, statistically significant coronavirus complication or pre-existing condition was registered as the underlying causes of death. In Austria, Bavaria, Czechia and Lithuania the scale of COVID-19 mortality would have been up to 18–27% higher had COVID-19 been coded as the underlying cause of death. Unrecognised coronavirus deaths were equivalent to the entire surplus of excess mortality beyond registered COVID-19 deaths in Austria and the Czech Republic, and its large proportion (25–31%) in Lithuania and Bavaria.

Conclusions
Death certificates with typical coronavirus complications or comorbidities as the underlying causes of death and contributing COVID-19 mentions were plausibly unrecognized coronavirus deaths.
Age at natural menopause and associated factors with early and late menopause among Chinese women in Zhejiang province: A cross-sectional study
Authors: Jiao Jie , Hao Jiajun , Hou Leying , Luo Zeyu , Shan Shiyi , Ding Yuehong , Ma Linjuan , Huang Yizhou , Ying Qian , Wang Feixue , Zhou Jianhong , Ning Yumei , Song Peige , Xu Ling 
Published: July 2024

Objectives
Menopause is a significant life transition for women, impacting their physical and psychological health. The age at natural menopause (ANM) and its associated factors have differed by race and region. This study aimed to investigate ANM and associated factors of early and late menopause among Chinese women in Zhejiang province.

Methods
A cross-sectional study was conducted using a multi-stage stratified cluster sampling method to recruit 8,006 women aged 40–69 years who had resided in Zhejiang province for over 6 months between July 2019 and December 2021. Self-reported ANM and sociodemographics, lifestyle behaviors, reproductive history, and health-related factors were collected using questionnaires in face-to-face surveys. ANM were categorized into three groups: early menopause (<45 years), normal menopause (45–54 years), and late menopause (≥55 years). Kaplan-Meier survival analysis was utilized to calculate the median ANM. Multivariable multinomial logistic regression was employed to explore the associated factors of early menopause and late menopause.

Results
A total of 6,047 women aged 40–69 years were included for survival analysis, with 3,176 of them for the regression analysis. The overall median ANM was 51 years (Inter-quartile range [IQR]: 51–52). Women who were smokers (odds ratio [OR]:4.54, 95% confidence interval [CI]:1.6–12.84), had irregular menstrual cycles (OR:1.78, 95% CI:1.12–2.83) and hypertension (OR:1.55, 95% CI:1.09–2.21) had a higher odds ratio of early menopause, while central obesity (OR:1.33, 95% CI:1.03–1.73) and hyperlipidemia (OR:1.51, 95% CI:1.04–2.18) were factors associated with late menopause.

Conclusions
This study revealed the associations between ANM and various factors among Chinese women. These factors included socio-demographic factors such as age; life behavior factors like current or prior smoking status; reproductive history factors such as irregular menstrual cycles, miscarriages, and breastfeeding; and health-related factors like central adiposity, hypertension, and hyperlipidemia. These findings provided a basis for understanding factors associated with ANM.
Markers of chronic low-grade inflammation and serum cytokine levels in patients with type 1 diabetes: associations with time in ranges and glucose variability
Authors: Mavlianova K. R. , Semenova Ju. F. , Orlov N. B. , Klimontov V. V. 
Published: July 2024

BACKGROUND: Increased glucose variability is recognized as a risk factor for vascular diabetic complications. It is assumed that deteriorating effect of GV on blood vessels can be realized through the activation of inflammatory signaling pathways.AIM: to determine associations of low-grade inflammation markers and serum cytokines with time in ranges and GV parameters derived from continuous glucose monitoring (CGM) in patients with type 1 diabetes (T1D).MATERIALS AND METHODS: In 470 adult patients with T1D, high-sensitivity C-reactive protein (hsCRP) and fibrinogen was measured, neutrophil-lymphocyte ratio (NLR) and the Systemic Immune-inflammation Index (SII) were calculated. In a sample of 130 patients and 20 healthy individuals (control), serum concentrations of interleukins (IL-1β, IL-4, IL-6, sIL-6Rα, IL-19, IL-20, IL-22, IL-26, IL-27, IL-28A, IL-29, IL-32, IL-34, IL-35) were assessed by multiplex analysis. Time in the ranges and GV parameters: Coefficient of Variability (CV), Mean Amplitude of Glycemic Excursions (MAGE), and Mean Absolute Glucose rate of changes (MAG) were derived from CGM data.RESULTS: Patients with Time In Range (TIR) <70% had higher concentrations of hs-CRP and fibrinogen, higher SII values, and demonstrated a trend toward higher TIR compared with those with TIR ≥70% (p=0.018, p=0.026, p=0.037, p=0.101, respectively). Patients with T1D, when compared to control, demonstrated increased concentrations of IL-1β (p<0.0001), IL-6 (p<0.0001), decreased levels of IL-4 (p=0.002), and a tendency to decrease IL-22 and IL-29 (p=0.1). Patients with TIR>70% had higher levels of IL-4 (p=0.02) as well as lower concentrations of IL-1β (p=0.0003) and IL-6 (p=0.007) than patients with TIR≤70%. In a multivariate stepwise regression analysis including clinical data and CGM parameters as independent variables, body mass index was positive predictor of hsCRP and fibrinogen levels, TIR was negatively associated with IL-20 and IL-34, time above range was associated positively with IL-1β, MAGE showed positive association with SII, IL-26 and IL28A, while MAG was positively associated with IL-29.CONCLUSION: T1D patients with non-target TIR (<70%) have higher levels of low-intensity inflammatory markers and serum pro-inflammatory cytokines than patients with TIR>70%. Both hyperglycemia and increased GV are associated with intensity of low-grade inflammation in T1D.
Effectiveness and safety of an artificial intelligence-based medical decision support system for adjusting insulin pump settings in children with type 1 diabetes mellitus: randomized controlled trial
Authors: Laptev D. N. , Sorokin D. Yu. , Trufanova E. S. , Rebrova O. Yu. , Bezlepkina O. B. 
Published: July 2024

BACKGROUND: Previously, we presented the process of developing a clinical decision support system (CDSS) for adjusting insulin pump (IP) settings in children with type 1 diabetes mellitus (T1D) and assessing the agreement of the recommendations it generates with the expert opinion. The CDSS demonstrated satisfactory forecasting of glucose profile and agreement rates between recommendations CDSS and experts.AIM: To evaluate the effectiveness and safety of using CDSS in children with T1D, testing the hypothesis of non-inferiority (with a limit of -5%) of relative increase of glucose time in range (TIR) over 6 months.MATERIALS AND METHODS: The trial included 80 children with T1D, divided into two comparable groups of 40 children using the minimization method. Patients in the main group received recommendations for adjusting the IP settings from a physician who uses the CDSS; patients in the control group received recommendations from a physician (control group). Patients were observed for 6 months with remote consultations once a month (7 consultations in total) and monitoring of glycated hemoglobin (HbA1c) at 1, 4 and 7 consultations. The primary outcome is the difference in group mean relative changes in TIR (%), secondary outcomes are TIR (%), HbA1c concentration. RESULTS: The trial was completed by 63 patients 32 in the main group, 31 in the control group. The difference in the mean relative increase in TIR at the 7th consultation in the groups was 3.02%, one-sided 95% CI (-4.55%; inf ). Thus, the lower bound of this CI is greater than the noninferiority limit of -5%, and the noninferiority hypothesis can be accepted. There were no statistically significant differences between groups for all outcomes. The dynamics of the indicators were positive in the main group and had a statistical tendency towards positive changes in the control group.CONCLUSION: The use of CDSS was no less effective in terms of the TIR than the management of the patient by a physician. The use of CDSS in clinical practice can help in regular and frequent monitoring of children with T1D, and standardize at a high level the approach to correction of IP parameters, supplemented with CGM.
Insufficiency/deficiency of vitamin B12 in patients in the endocrinological practice
Authors: Mokrysheva N. G. , Shestakova M. V. , Ametov A. S. , Antsiferov M. B. , Bakulin I. G. , Vavilova T. V. , Galstyan G. R. , Demidova T. Y. , Dzgoeva F. K. , Karonova T. L. , Lukina E. A. , Mkrtumyan A. M. , Petunina N. A. , Ponomaryov R. V. , Suponeva N. A. , Sukhareva O. Y. , Shamkhalova M. S. 
Published: July 2024

On March 20, 2024, an interdisciplinary meeting of the Expert Council on the current problem of B12 insufficiency/deficiency and the prevalence of this condition among endocrine patients was held at the Endocrinology Research Centre (Moscow). The purpose of the meeting was to assess the role of B12 deficiency in reducing the quality of life of patients of different groups and to outline a strategy for the management of patients with vitamin B12 insufficiency/deficiency by endocrinologists.The resolution of the expert council was developed by leading specialists in various specialties.
Finding and sharing educational resources using Twitter, Hashtags and Storify
Authors: McGuire Mark 
Published: July 2024

This paper reports on the use of Twitter, hashtags and Storify to connect with individuals inside and outside the university who have a shared interest in the future of libraries. The objective was to discover and share educational resources that were applicable to a class project, by engaging with experts through social media, rather than by searching for the resources directly. A related aim was to discover how even limited social contact with others could result in a more collaborative, networked approach to problem solving, in keeping with contemporary design practice. Over the 13-week course, 250 Twitter messages were collected, narrated and archived by the course Lecturer (and author), using Storify. During class discussions, students reported that the resources were useful, and they commented on the effectiveness of reaching out beyond the classroom in this way. This trial also provided insights into how such collaborations could be taken further.
(Im)mobility infrastructure and the production of the linguistic precariat
Authors: Yilmaz Birgul 
Published: July 2024

Abstract
Based on an 18 month long ethnographic fieldwork in self-organised English language lessons in a radical café and a squat in two neighbourhoods of Athens, this article deals with (im)mobility infrastructure and the production of the linguistic precariat in Greece. To do this, I investigate how waiting as a bordering technology shapes language learning practices of refugees whilst they plan their journeys to northern Europe via human smugglers. I explore how language and communication intersect with (im)mobility infrastructure, how it is rationalised and what it does in the context of forced migration. More specifically, I investigate how language learning and communication practices of refugees are shaped by this apparatus and turn them into the linguistic precariat. The notion of linguistic precariat refers to uncertainties, anxieties, vulnerabilities, insecurities experienced by individuals who make temporary investments in their language learning choices. I discuss how my participants, including refugees and anti-authoritarians, mobilise vulnerability, lack of language(s), through self organised teaching and learning, to reduce condition of precarity.
Anti-OTC antibody-conjugated fluorescent magnetic/silica and fluorescent hybrid silica nanoparticles for oxytetracycline detection
Authors: Kaliyaperumal Viswanathan , Al-Otibi Fatimah Oleyan , John Ruth Sophila , Alharbi Raedah Ibrahim , Gopal Dhinakar Raj 
Published: July 2024

Abstract
This study presents two alternative fluorescent nanoparticle-based oxytetracycline (OTC) detection methods in milk samples. Rhodamine 6G-coated fluorescent hybrid silica nanoparticles and fluorescent magnetic/silica nanoparticles functionalized with anti-OTC antibodies were used in this test. The sandwich test format was utilized to compare anti-OTC antibody-conjugated fluorescent magnetic/silica nanoparticles with OTC/OTC antibody-conjugated fluorescent hybrid silica nanoparticles in an Eppendorf tube with magnetic separators. The magnetic separator helps to quickly retain all of the OTC captured by fluorescent magnetic core–shell nanoparticles in the milk sample. As a result, the assay time was dramatically shortened. The obtained linear range was 1.34 × 10−6 to 2.10 × 10−8 (M) (R
2 = 0.9954), the detection limit was 4.76 ng/mL, and the total assay time was 90 min. This approach was used to determine the OTC concentration in milk samples, and the maximum percentage (%) of interference was less than 3.0%, with a recovery rate of greater than 97.0%. This approach offers a high potential for residue detection in milk samples. With a total analysis period of less than 90 min, this approach provided the best way to determine the capture and detector nanoparticles’ response.
Visible light-boosted photodegradation activity of Ag–AgVO3/Zn0.5Mn0.5Fe2O4 supported heterojunctions for effective degradation of organic contaminates
Authors: Jasim Nuralhuda Aladdin , Ebrahim Shahlaa Esmail , Ammar Saad H. 
Published: July 2024

Abstract
One of the most important concerns in developing efficient heterojunction photocatalysts for the photodegradation of environmental contaminants is the enhancement and acceleration of photocarrier separation. In this study, novel nanocomposite photocatalysts of Ag–AgVO3 nanorods grafted with Zn0.5Mn0.5Fe2O4 metal ferrites nanoparticles were developed by using facial hydrothermal and coprecipitation techniques for the effective photodegradation of Rhodamine B (Rh B) under visible light exposure. The fabricated materials were analyzed in detail using scanning electron microscopy, energy-dispersive X-ray spectroscopy (EDS), nitrogen adsorption/desorption, transmission electron microscopy (TEM), photoluminescence spectroscopy (PL), vibrating sample magnetometer, and ultraviolet–visible diffuse reflectance spectroscopy (DRS). The results showed an efficient contribution when compared to the earlier research. The TEM showed a hybrid of nanorods of supported composite with metal ferrite and Ag attached on the surface, consistent with field emission scanning electron microscopy and EDS results. The DRS expressed a lower band gap for supported nanocomposites (1.5 eV), which, arranged with PL, showed a lower recombination rate of supported nanocomposites. The surface properties showed that the supported hybrid might be as small as 45.42 nm or as large as 20.33 nm compared with others. When comparing the photocatalytic activity of pure AgVO3, Ag/AgVO3, and Zn0.5Mn0.5Fe2O4 photocatalysts, the performance of Ag–AgVO3/Zn0.5Mn0.5Fe2O4 nanocomposite photocatalyst was clearly superior (more than 99.9% degradation efficiency was achieved). The boosted activity the Ag–AgVO3/Zn0.5Mn0.5Fe2O4 photocatalyst system was justified by Z-system heterojunction induced by the plasmonic effect, and the suggested mechanism was investigated by quenching of reactive species by scavengers. The degradation performance was achieved under optimum conditions (pH = 2, 20 ppm of pollutant concentration, 120 mM of hydrogen peroxide, 1 g/L of catalysts dose). The results showed that after 240 min of visible irradiation resulted in the high (chemical oxygen demand) and (total organic carbon) reductions with a removal efficiency of (85) to (90%) for Rh B dye. The fabricated Ag–AgVO3/Zn0.5Mn0.5Fe2O4 nanocomposites were effective in the degradation of organic pollutants in wastewater treatment.
The effect of biostimulants and red mud on the growth and yield of shallots in post-unlicensed gold mining soil
Authors: Surachman Surachman , Palupi Tantri , Purwaningsih Purwaningsih , Gafur Sutarman 
Published: July 2024

Abstract
Shallot production in West Kalimantan is still low. Land that has the potential for the development of shallots is the soil from post-unlicensed gold mining (PUGM). The soil at PUGM was exploited very extensively and can be used to develop shallots, but it is obstacled by low pH values and nutrient content. This research aims to investigate the impact of biostimulants and red mud on the growth and yield of shallots. The experiment was carried out in two stages: (1) investigated the ratio of the red mud and PUGM soil at the laboratory and (2) investigated the biostimulants and red mud effect on two varieties of shallots in a screen house. For the second experiment, there were three factors. The first factor was the biostimulant (0, 2, 3, and 4%); the second factor was the dose of red mud (0, 2, and 4 tons ha−1); and the third factor was the shallot varieties (Bima Brebes and Tajuk). The results of the first research indicated that the application of the red mud and PUGM soil in a ratio of 1:500 and 1:1,000 had a pH of 7.88 (slightly alkaline) and 7.24 (neutral), respectively. The second study found that a 2% concentration of biostimulant increased plant height and tuber count by 23.78 cm and 6.55 tubers, respectively. The Bima Brebes variety produced better fresh tubers weight clump−1 and dry tubers weight clump−1 than the Tajuk variety, with, respectively, 42.08 g (7.36 tons ha−1) and 32.60 g (5.71 tons ha−1). These findings show that the use of the biostimulants and red mud together in integrated management can help shallots grow and produce more, especially on PUGM land that has obstacles with low soil fertility. This research contributes to the identification of sustainable solutions for agricultural development in environments that have experienced severe land degradation, such as unlicensed gold mining activities.
The Περὶ ποιητῶν Literature. A General Outline and Survey of the Extant Fragments
Authors: Pelucchi Marco 
Published: July 2024

Abstract
The Greek manuscript tradition transmits various fragments of works with the title Περὶ ποιητῶν, composed by both philosophers and grammarians from the Classical to the Imperial periods. The aim of this paper is to analyse these surviving fragments with a view to delineating the contents, forms, and characteristics of this type of literature. In the first part, I propose a survey of all authors and fragments of ancient Greek works On Poets. The second section outlines their literary-historical profile. Based on comparison with ancient works treating similar topics, I suggest a unitary reading of the writings Περὶ ποιητῶν. Through a combination of biographical, exegetical, theoretical, and (perhaps) technical information, this type of literature appears to have comprised the earliest “histories” of ancient poetry.
Human estrogen receptor alpha (ERα) targeted cyclic peptides inhibit cell growth and induce apoptosis in MCF-7 cells
Authors: Şentürk Hilal , Dedeakayoğulları Huri , Marion İlke U. , Özçubukçu Salih , Kesici Mehmet S. , Ünsal Beyge Şeyma , Acar Muradiye , Erkısa Genel Merve , Akbaş Fahri , Ulukaya Engin 
Published: July 2024

Abstract

Objectives
Human estrogen receptor alpha (ERα) is considered an important target, especially in the treatment of breast cancer, as it has a vital role in cancer development. ERα-targeted therapies generally target the ligand binding domain (LBD) of ERα. However, over time, cells develop resistance to this mechanism alternative approaches to inhibit ERα activity target ERα–DNA or ERα–cofactor interactions. Inhibitors of ERα–cofactor interactions are designed by targeting the hydrophobic hollow region of the receptor box LXXLL motif.

Methods
In this context, helix-stabilized cyclic peptides (SPs) designed with in silico approaches were obtained by solid phase peptide synthesis. The effects of SPs on MCF-7 cells were examined with MTT and ATP, and qPCR and flow cytometry were used for further analysis.

Results
Our results demonstrated that the SPs were effective only in MCF-7 cells expressing ERα. In addition, cyclic peptide combinations (SPCs) showed anti-proliferative and toxic effects on MCF-7 cells. The impact of SPCs with the highest inhibitory effect in MCF-7 cells on ERα-related genes and markers of apoptosis was revealed. Moreover, the flow cytometry analysis result used to examine apoptotic cells proved the apoptosis of SPCs in MCF-7 cells.

Conclusions
These findings suggest that our novel SPs, which inhibit coactivator interactions of ERα, induce apoptosis of MCF-7 cells. Thus, considering this strong effect of SPs in the inhibition of receptors, it is pointed out that they can be further developed as an alternative to current clinical treatments or as an auxiliary approach in the generating of new targeted peptide-based therapies.