bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Association of GW190425 with Its Potential Electromagnetic Counterpart FRB 20190425A
Authors: Magaña Hernandez Ignacio , d’Emilio Virginia , Morisaki Soichiro , Bhardwaj Mohit , Palmese Antonella 
Published: August 2024

Abstract
Recent work by Moroianu et al. has suggested that the binary neutron star (BNS) merger GW190425 might have a potential fast radio burst (FRB) counterpart association, FRB20190425A, at the 2.8σ level of confidence with a likely host galaxy association, namely UGC10667. The authors argue that the observations are consistent with a long-lived hypermassive neutron star (HMNS) that formed promptly after the BNS merger and was stable for approximately 2.5 hr before promptly collapsing into a black hole. Recently, Bhardwaj et al. conclusively associated FRB20190425A with UGC10667, potentially providing a direct host galaxy candidate for GW190425. In this work, we examine the multimessenger association based on the spacetime localization overlaps between GW190425 and the FRB host galaxy UGC10667 and find that the odds for a coincident association are

O
(
5
)

. We validate this estimate by using a Gaussian process density estimator. Assuming that the association is indeed real, we then perform Bayesian parameter estimation on GW190425 assuming that the BNS event took place in UGC10667. We find that the viewing angle of GW190425 excludes an on-axis system at p(θ

v
> 30°) ≈ 99.99%, highly favoring an off-axis system similar to GRB 170817A. We also find a slightly higher source frame total mass for the binary, namely,

m

total

=

3.42

−
0.11

+
0.34

M

⊙

, leading to an increase in the probability of prompt collapse into a black hole and therefore disfavors the long-lived HMNS formation scenario. Given our findings, we conclude that the association between GW190425 and FRB20190425A is disfavoured by current state-of-the-art gravitational-wave analyses.
The Dermatomyositis Disease Symptom Questionnaire (DM-DSQ): A Measure to Assess the Patient Experience of Dermatomyositis Symptoms
Authors: Christopher-Stine Lisa , Ciesluk Anna , Chinoy Hector , Goyal Namita A. , Gunter Kaniah , Isenberg David , Kielhorn Adrian , Lundberg Ingrid E. , Mozaffar Tahseen , Rakhade Sanjay , Vandenberg Gerrit , Aggarwal Rohit 
Published: August 2024

ObjectiveDermatomyositis (DM) symptoms negatively affect the quality of life of individuals living with the disease. Disease-specific, patient-reported outcome (PRO) instruments are needed to assess symptoms important to individuals with DM. This study aimed to conceptualize patient DM experience and disease activity definition to refine the development of the Dermatomyositis Disease Symptom Questionnaire (DM-DSQ), a novel PRO instrument capturing patient-reported symptoms.MethodsAn observational, qualitative study was conducted with 30 individuals with DM (aged ≥ 18 yrs) in the US. A 1-hour semistructured interview, including concept elicitation and cognitive debriefing, was conducted with each participant. Inductive coding was used to identify concepts; a saturation analysis was conducted to confirm sample size. Concepts from transcripts were used to refine the preliminary conceptual model and DM-DSQ items.ResultsConcept elicitation analysis findings included disease symptoms (eg, muscle weakness) and functional impacts (eg, walking). The analysis achieved conceptual saturation; the first 5 interviews uncovered most of the concepts. During cognitive debriefing of the DM-DSQ, participants found the items relevant, comprehensive, and easily understood (except for “skin sensitivity in sunlight”). The revised DM-DSQ content appears preliminarily valid in the patient population surveyed, pending further additions and debriefing based on refinement of the preliminary conceptual disease model and items.ConclusionThe DM-DSQ is being used in a phase II clinical trial and could become a valuable tool for studies evaluating PROs in patients with DM. Preliminary results indicate its content validity; extensive psychometric analysis using clinical trial data will determine its ability to capture symptoms for patients with DM.
Understanding the Role of the Complement System in Insulin Resistance and Metabolic Syndrome in Patients With Rheumatoid Arthritis
Authors: Rodríguez-González Dara , García-González María , Gómez-Bernal Fuensanta , Quevedo-Abeledo Juan C. , González-Rivero Agustín F. , González-López Elena , Ocejo-Vinyals J. Gonzalo , González-Gay Miguel Á. , Ferraz-Amaro Iván 
Published: August 2024

ObjectiveThe complement system has been associated with the etiopathogenesis of rheumatoid arthritis (RA). Insulin resistance (IR) and metabolic syndrome (MetS) are prevalent among patients with RA. The aim of this study was to explore the relationship between a comprehensive evaluation of the complement system and IR, as well as MetS, in patients with RA.MethodsA total of 339 nondiabetic patients with RA were recruited. Functional assays of the 3 complement pathways were assessed. Additionally, serum levels of the following individual components of the complement system were measured: C1q (classical); lectin (lectin); C2, C4, and C4b (classical lectin); factor D and properdin (alternative); C3 and C3a (common); C5, C5a, and C9 (terminal); as well as the factor I and C1 inhibitor regulators. IR and β cell function indices were calculated using the homeostatic model assessment. Criteria for MetS were applied. Multivariable linear regression analysis was performed to investigate the association between the complement system and IR in patients with RA.ResultsMany elements of the upstream and common complement pathways, but not the functional tests of the 3 routes, correlated positively with higher levels of IR and β cell function. However, after multivariable adjustment for factors associated with IR, these relationships were lost. Conversely, the presence of MetS in patients with RA maintained a relationship with higher levels of C1q, C4, C3, properdin, and factor I after adjusting for confounders.ConclusionThere is a positive correlation between the complement system and MetS among nondiabetic patients with RA. This association is independent of traditional IR factors.
Development of a Critical Reflection Mentorship Program to Enhance Critical Thinking Among Novice Nurses
Authors: Geist Nicole C. , Browning Mary , Messick Amber 
Published: August 2024

Background:
The increasing complexity of care and the decrease in overall nursing experience pose a threat to patient safety and clinical outcomes in health care. Within the local environment, a critical need was identified to connect expert bedside nurses with novice nurses to support the development of critical thinking.

Method:
This article describes the development and pilot evaluation of a critical reflection mentorship program, Beyond the Bedside. The program was developed and deployed in three inpatient units within an adult academic health center. Critical thinking was evaluated using the Nursing Critical Thinking in Clinical Practice Questionnaire (N-CT-4 Practice) pre- and postprogram implementation.

Results:
Five nurses participated in the pre- and postevaluation, and the N-CT-4 Practice mean scores were significantly higher after program implementation.

Conclusion:

Education leaders should prioritize programs that support critical thinking among novice nurses, and the Beyond the Bedside program can be adapted for use in other health care settings.

[
J Contin Educ Nurs.
2024;55(9):456–460.]
Psychosocial Factors and Quality of Life in Older Adults Discharged After Isolation Due to COVID-19 Infection
Authors: Choi Joo Young , Kim Kisook 
Published: August 2024

Purpose:
To identify the impact of psychosocial factors on quality of life (QoL) of older adults hospitalized and isolated after contracting coronavirus disease 2019 (COVID-19).

Method:
Data were collected between April 30 and June 18, 2022, from 117 discharged older adults who were in isolation for COVID-19 treatment in a tertiary hospital in South Korea.

Results:

Of participants, 33.3% were at high risk for posttraumatic stress symptoms (PTSS), and 21.4% of participants were identified as having severe depressive symptoms. Participants' QoL negatively correlated with PTSS, depressive symptoms, and fear of social stigma. Depressive symptoms were the primary psychosocial factor identified as significantly affecting QoL (β = −0.682,
p
< 0.001), and the explanatory power of the regression model was 41.2%.

Conclusion:

To enhance QoL of older adults who have experienced hospitalization and isolation due to COVID-19, identifying pertinent psychosocial factors, especially depressive symptoms, is necessary. [
Journal of Gerontological Nursing, 50
(8), 29–36.]
Cardiac Arrest Due to Capecitabine Toxicosis Treated With ECMO and CRRT: A Case Report
Authors: Zhang Liqin , Liu Mingjun , Xie Lutao , Tian Xin 
Published: August 2024

Introduction
This is the first report of a patient who developed cardiogenic shock after receiving oral chemotherapy with capecitabine and was treated with venoarterial extracorporeal membrane oxygenation combined with continuous renal replacement therapy.

Clinical Findings
A 58-year-old man developed an arrhythmia that rapidly progressed to cardiogenic shock and cardiac arrest after receiving oral capecitabine tablets to treat a rectal malignancy.

Interventions
The patient was treated with venoarterial extracorporeal membrane oxygenation in combination with continuous renal replacement therapy.

Outcome
The patient made a full recovery and was discharged from the hospital.

Conclusion
The use of comprehensive supportive treatments such as extracorporeal membrane oxygenation combined with continuous renal replacement therapy in patients with capecitabine-induced cardiac arrest can rapidly reduce drug concentrations, eliminate harmful substances, and improve the prognosis.
Prevalence, severity, associated factors and assessment of risk for falls among elderly in Sri Lanka
Authors: Jeyapragasam Hajanthy , Ilukkumbura Ajani S. , Jayakody Punu , Chang Thashi 
Published: August 2024

Background: Falls among the elderly is a significant global health problem. Therefore, we aimed to study the prevalence, severity, and factors associated with falls among community-dwelling elders and assess their future risk of falls.Methods: A descriptive cross-sectional study was conducted among 128 residents aged ≥65 years from a housing complex in Colombo, Sri Lanka. Participants were selected using systematic sampling. Data were obtained using an interviewer-administered questionnaire. Disability, cognition and future falls risk were assessed using the modified Rankin scale (mRS), the Montreal Cognitive Assessment (MoCA) tool and the QuickScreen (QS) tool, respectively.Results: Among the participants, 54.7% were aged 65-74 years and 55.5%were women. Prevalence of falls was 44.5% in the last five years and 17.2% in the last one year. Of those who fell, 2.4% had significant disability (mRS≥3) and 63.2% required medical attention. Cognitive impairment (MoCA<26/30) was found among 84.4%. Diabetes (36.7%), hypertension (60.9%), backache (59.4%), obesity (65.6%), impaired mobility and vision impairment (71.9%) were the identified biological risk factors. Slippery floors (38.3%) were the commonest environmental risk factor. Among the participants 35.9% were taking >3 types of medications. In the mobility tests, 66.4% failed the alternate step test, 64.1% failed the sit to stand test while 25% failed the near tandem test. Based on the QS scores, the fall risk in the ensuing 12 months was found to be high in seven participants (5.5%), moderate in 86 (67.1%) and low in 35 (27.3%).Conclusion: Falls among elderly were common and was associated with significant morbidity. Many elders possessed more than one risk factor for falls and the future falls risk was found to be moderate to high.
Six-Minute Walk Test among obese and nonobese subjects: A comparative analysis among apparently healthy volunteers
Authors: Ghosh Tandra , Shinde Manjusha Ashlesh , Kawale Suchita Narayan , Kumar Shiv , D’Souza Aparajita Sophia 
Published: August 2024

Abstract

Context:
The Six-Minute Walk Test (6MWT) is a simple measure for objective assessment of physical fitness and exercise tolerance. It has also been standardized to follow up on the prognosis and progression of chronic cardiovascular and respiratory diseases. Though there are standardized formulas for analyzing the 6MWT results concerning age, height, weight, regional, and ethnic population these should be revisited considering the wider variations of subjects in the reference studies.

Aim:
This article aims to compare the 6MWT performance among obese and nonobese, apparently healthy volunteers.

Settings and Design:
A cross-sectional study was conducted in the Physiology Department, AIIMS Kalyani, West Bengal, India.

Materials and Methods:
Age and sex-matched apparently healthy volunteers were included in the study after their consent. After collection of anthropometric data, they were divided into two groups; group A with body mass index (BMI) <30 kg/m2 and group B with BMI >30 kg/m2. The 6MWT was implemented according to standard guidelines; the Six-Minute Walk Distance (6MWD) and other parameters were noted. Statistical analysis was performed by Statistical Package for the Social Sciences software version 17 (IBM Corp., Chicago, IL, USA).

Results:
The results revealed that a comparison was done between actual values and predicted values of 6MWD. Among obese groups, the actual 6MWD covered was significantly lesser than the predicted values. Significant differences were also found between the two groups concerning Borg score, Calculated volume of oxygen max, systolic and diastolic blood pressures, respiratory rate, heart rate, and Peripheral capillary oxygen saturation.

Conclusions:
The results revealed that our result shows that the weight-based reference equation for interpretation of 6MWT may not be sufficient for obese subjects.
Medical professionals as victims of human rights violation
Authors: Chattopadhyay Saurabh 
Published: August 2024

Abstract
Medical practice has changed a lot with the passage of time. The concept of an ideal human being in the form of a doctor is rare nowadays. This evolution is obvious, so as to keep pace with the modern society. The principles of Medical Ethics still holds good in today’s world, but certain modifications are necessary. The idea behind these principles is to safeguard the interest of the patient. With the rapid spread of digital technology, access to the internet and social networking the face of doctor patient relationship has gained a new dimension. The patient enjoys his autonomy and has the scope of verifying and cross examining the physician regarding the treatment. The principle of non-maleficence implies that the doctor will do no harm to the patient even if he is unable to provide treatment that is, beneficial for the patient. But does the same principle hold good for the patient too? If the patient is not satisfied with the treatment he has the right to lodge complaint against the physician and frame charges of medical negligence. This act does not conform to the principle of non-maleficence on the part of the patient. Moreover the lack of autonomy for the doctor and the mental stress of litigations constitute violation of human rights for the practitioners. Hence abiding by the principles of medical ethics may lead to victimization of human rights violation. The Principles of “Dignity” and “Unity” need to be incorporated in view of the present scenario and changing trends in medical practice.
Safety Assessment of 6’-Sialyllactose (6’-SL) Sodium Salt as a Novel Food for Use in Food and Food Supplements (RP1478)
Authors: Food Standards Agency  , Food Standards Scotland  
Published: August 2024

The Food Standards Agency (FSA) and Food Standards Scotland (FSS) received an application from Kyowa Hakko Bio Company Ltd, Japan (“the applicant”) for the authorisation of 6’-sialyllactose (6’-SL) sodium salt as a novel food in March 2022. The novel food is intended to be used as a source of human identical milk oligosaccharide, 6’-SL, and is manufactured by microbial fermentation using a genetically modified strain of Escherichia coli W, and then refined to yield the purified powder. This new application is seeking to use the novel food within the food categories: dairy products and analogues, bakery wares, foods for special groups, beverages, and food supplements. Food supplements are not intended to be used if other foods with added 6’-SL or breast milk are consumed on the same day. To support the FSA and FSS in their evaluation of the application, the Advisory Committee on Novel Foods and Processes (ACNFP) were asked to review the safety dossier and supplementary information provided by the applicant. The views of the Committee were taken into account by the FSA and FSS who concluded that the applicant had provided sufficient information to assure the novel food, 6’-SL sodium salt, was safe under the proposed conditions of use. The anticipated intake levels and the intended use in food and food supplements was not considered to be nutritionally disadvantageous. This safety assessment represents the opinion of the FSA and FSS.
PENINGKATAN KEMAMPUAN MENULIS TEKS CERPEN DENGAN PENGGUNAAN MEDIA KARTU SISWA KELAS IXC MADRASAH TSANAWIYAH NEGERI 2 KUANTAN SINGINGI TP.2022/2023 KECAMATAN SENTAJO RAYA KABUPATEN KUANTAN SINGINGI
Authors: Juliana Juliana 
Published: August 2024

The purpose of this research was to describe and to explain the increasing process of writing short story ability by using flashcards in class IX C of State Islamic School 2 Kuantan Singingi academic year 2022/2023 Sentajo Raya District Kuantan Singingi Regency. The research was classroom action research. The research consisted of 3 cycles, each cycle covered: planning, acting, observing, and reflecting. The subject of the research was the students of Class IX C of State Islamic School 2 Kuantan Singingi, which consisted of 32 students with different social and financial backgrounds. Due to the difference in the social and financial background of the students, the teacher must have used suitable teaching method in teaching and learning process. The data collecting technique was descriptive quantitative. The research was conducted from June to December 2022. Based on the result of the pre cycle in writing short story, the student’s ability in writing short story did not meet expectation yet. Thus, based on the data collected, it was concluded that writing short story by using flashcard as media increased students’ results and activities in the learning process.

Tujuan penelitian ini adalah untuk mendeskripsikan dan menjelaskan proses peningkatan kemampuan menulis teks cerpen melalui media kartu kelas IXC MTs negeri 2 Kuantan Singingi TP. 2022/2023 Kecamatan Sentajo Raya kabupaten Kuantan Singingi. Jenis penelitian ini merupakanPenelitian Tindakan Kelas. Penelitian ini terdiri dari 3 siklus masing masing siklus meliputi:perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian ini adalah siswa kelas IXC MTs Negeri 2 Kuantan Singingi yang berjumlah 32 dengan latar belakang sosial dan ekonomi yang berbeda. Dengan adanya perbedaan tersebut guru harus mampu menemukan metode yang tepat dalam pembelajaran.Teknik pengumpulan data dalam penelitian ini adalah metode deskriptif kuantitatif. Penelitian ini dilakukan dari bulan Juli sampai bulan Desember 2022. Dari hasil menulis teks cerpen yang dilaksanakan pada prasiklus, keterampilan siswa masih belum menunjukkan hasil yang memuaskan. Dari lima indikator yang telah ditentukan rata-rata nilai siswa dalam menulis teks cerpen hanya mencapai (kelengkapan struktur 89,6, kesesuaian tahapan alur 60,1 ,penegembangan latar 67,1, pengembangan watak tokoh 75,7 dan kebahasaan 82,8). Dapat disimpulkan bahwa materi pembelajaran menulis teks cerpen dengan media kartu dapat meningkatkan hasil belajar dan aktivitas siswa dalam PBM
Artificial Intelligence-Based Prediction of Intra-Aortic Balloon Pump Need in High-Risk CABG Surgery: Enhancing Clinical Decision Support
Authors: Wajeeh Zainab A. , Hamandi Sadiq J. , Al-Obaidi Wisam S. , Kervan Umit 
Published: August 2024

Background: In modern healthcare, decision-making processes are becoming increasingly data-driven, aiming to optimize patient care and resource allocation. Coronary artery bypass grafting (CABG) is a critical procedure for high-risk patients, and the use of intra-aortic balloon pump (IABP) assistance can significantly impact patient outcomes.
Objective: To identify preoperative factors that predict the need for IABP assistance in high-risk CABG patients and to develop a predictive model that can enhance clinical decision-making.
Subjects and Methods: The study involved fifty high-risk coronary artery bypass graft patients, with 24 cases necessitating intra-aortic balloon pump assistance and the rest not requiring it. Seven preoperative variables, including age, weight, ejection fraction, number of grafts, creatinine level, diabetic status, and blood pressure, were considered as potential predictors. SPSS was adopted to conduct a multi-variable regression analysis and derive the mathematical equations for the predictive model. A graphical user interface (GUI) was developed to utilize these equations for predicting the need for IABP support.
Results: The findings revealed a strong correlation among several preoperative factors and the likelihood of requiring IABP assistance. By employing the predictions from the model to guide preoperative intra-aortic balloon insertion, the potential for optimizing hemodynamic support during surgery was maximized.
Conclusions: This research emphasizes the importance of enhancing risk assessment techniques to empower medical specialists to tailor treatment plans to each patient's specific needs. Early identification of individuals at risk of requiring IABP can significantly enhance surgical outcomes and patient safety. Incorporating the predictive model into clinical practice allows for more individualized and effective care during high-risk CABG surgeries. This modern strategy has the potential to revolutionize cardiac outcomes, improve patient results, and extend the use of intra-aortic balloon support.
PENYULUHAN DAN PENATALAKSANAAN NYERI PUNGGUNG BAWAH PADA LANJUT USIA DI RW 02 DESA SAWANGAN KECAMATAN DORO KABUPATEN PEKALONGAN
Authors: Laela Rahmawati Fitriana , Ajie Pangestu Ahmad , Erlina Dina , Afifah Hani Amelia , Setyorianti Pramono Retno , Azkiya M.Azkal , Nooryana Syavira , Kartikasari Dian 
Published: August 2024

Lansia sehat berkualitas merupakan proses penuaan yang senantiasa sehat dan maksimal secara fisik, psikologis serta social. Nyeri punggung bawah adalah manifestasi kondisi patologis yang dirasakan oleh jaringan tubuh di bagian punggung ataupun yang terdapat di dekat punggung. Akibat nyeri punggung bawah pada lanjut usia dapat memunculkan perubahan pada kolagen yang menimbulkan berkurangnya fleksibilitas pada lanjut usia, maka bisa menimbulkan dampak antara lain nyeri, penurunan kemampuan dalam beraktivitas sehari-hari. Berdasarkan survei yang dilakukan, sebanyak 50% lansia mengeluhkan nyeri dipinggangnya. Edukasi yang dihadiri oleh 17 lansia ini disampaikan menggunakan power point dan poster. Pemberian edukasi ini meningkatkan pengetahuan lansia mengenai nyeri punggung bawah.