bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational readiness for knowledge translation in chronic care: a review of theoretical components
Authors: Attieh Randa , Gagnon Marie-Pierre , Estabrooks Carole A , Légaré France , Ouimet Mathieu , Roch Geneviève , Ghandour El Kebir , Grimshaw Jeremy 
Published: November 2013

Abstract

Background
With the persistent gaps between research and practice in healthcare systems, knowledge translation (KT) has gained significance and importance. Also, in most industrialized countries, there is an increasing emphasis on managing chronic health conditions with the best available evidence. Yet, organizations aiming to improve chronic care (CC) require an adequate level of organizational readiness (OR) for KT.
Objectives: The purpose of this study is to review and synthesize the existing evidence on conceptual models/frameworks of Organizational Readiness for Change (ORC) in healthcare as the basis for the development of a comprehensive framework of OR for KT in the context of CC.

Data sources
We conducted a systematic review of the literature on OR for KT in CC using Pubmed, Embase, CINAHL, PsychINFO, Web of Sciences (SCI and SSCI), and others. Search terms included readiness; commitment and change; preparedness; willing to change; organization and administration; and health and social services.
Study selection: The search was limited to studies that had been published between the starting date of each bibliographic database (e.g., 1964 for PubMed) and November 1, 2012. Only papers that refer to a theory, a theoretical component from any framework or model on OR that were applicable to the healthcare domain were considered. We analyzed data using conceptual mapping.
Data extraction: Pairs of authors independently screened the published literature by reviewing their titles and abstracts. Then, the two same reviewers appraised the full text of each study independently.

Results
Overall, we found and synthesized 10 theories, theoretical models and conceptual frameworks relevant to ORC in healthcare described in 38 publications. We identified five core concepts, namely organizational dynamics, change process, innovation readiness, institutional readiness, and personal readiness. We extracted 17 dimensions and 59 sub-dimensions related to these 5 concepts.

Conclusion
Our findings provide a useful overview for researchers interested in ORC and aims to create a consensus on the core theoretical components of ORC in general and of OR for KT in CC in particular. However, more work is needed to define and validate the core elements of a framework that could help to assess OR for KT in CC.
Bioethanol production from rice straw by popping pretreatment
Authors: Wi Seung Gon , Choi In Seong , Kim Kyoung Hyoun , Kim Ho Myeong , Bae Hyeun-Jong 
Published: November 2013

AbstractBackgroundRice straw has considerable potential as a raw material for bioethanol production. Popping pretreatment of rice straw prior to downstream enzymatic hydrolysis and fermentation was found to increase cellulose to glucose conversion efficiency. The aim of this study was to investigate the influence of popping pretreatment and determine the optimal enzyme loading using a surface response design.ResultsThe optimal doses of cellulase and xylanase enzymes were 23 FPU and 62 IU/g biomass, respectively. Using the optimized enzyme condition and popping pretreatment of rice straw (15% substrate loading, w/v), a sugar recovery of 0.567 g/g biomass (glucose; 0.394 g/g) was obtained in 48 h, which was significantly higher than that from untreated rice straw (total sugar recovery; 0.270 g/g biomass). Fermentation of the hydrolyzates bySaccharomyces cerevisiaeresulted in 0.172 g ethanol/g biomass after 24 h, equivalent to 80.9% of the maximum theoretical yield (based on the amount of glucose in raw material). Changes in the chemical composition and surface area of rice straw were also investigated before and after popping pretreatment. The results showed little or no difference in chemical composition between the pretreated rice straw and the control. However, the surface area of pretreated rice straw increased twofold compared to the control.ConclusionPopping pretreatment of rice straw can effectively improve downstream saccharification and fermentation, important for bioethanol production.
Penetrating orbit injury: challenge to emergency medicine
Authors: Malla Gyanendra , Bhandari Rabin , Gupta Pramendra Prasad , Giri Rajani 
Published: November 2013

Abstract

Background
Penetrating orbital injuries pose a serious threat to vision, ocular motility, and in some cases, life. The setting and causes of eye injury are diverse, but previous studies have demonstrated that the risk and type of injury is often correlated with age, gender, and race. Pediatric ocular injury is often accidental and may be preventable. A focused history and prompt ocular examination are essential to immediate management.

Case presentation
This article describes a case of protruding foreign body-related penetrating orbit injury with a retained foreign body in a 4-year-old male from a town in the eastern part of Nepal. The child presented to the emergency with foreign body in situ without receiving any pre emergency care without any medical attendance. The patient was managed with non-operative removal of foreign body in the emergency. The case discussion will review the initial presentation, examination, resultant management decisions, and final outcome.

Conclusion
Foreign body presentations may be diverse and non-operative management may be considered in selected cases. Resource availability and conditions at presentations may also influence the management decisions. This case presentation has described such a scenario in developing country like Nepal and is expected to be interest across various medical specialties.
QTL mapping reveals a tight linkage between QTLs for grain weight and panicle spikelet number in rice
Authors: Luo Xiao , Ji Shi-Dong , Yuan Ping-Rong , Lee Hyun-Sook , Kim Dong-Min , Balkunde Sangshetty , Kang Ju-Won , Ahn Sang-Nag 
Published: November 2013

Abstract

Background
A number of QTL studies reported that one genomic region was associated with several traits, indicating linkage and/or pleiotropic effects. The question of pleiotropy versus tight linkage in these studies should be solved using a large-size population combined with high-density mapping. For example, if each of the 2 parents has a TGW-increasing or SPP-increasing QTL that is tightly linked, complementary combination of the 2 beneficial QTLs by using molecular markers could produce higher yields compared to the 2 parents. However, a pleiotropic QTL with opposite effects on the SPP and 1,000-grain weight (TGW) is complicated and challenging in terms of its application to rice improvement.

Results
In this study, using a series of BC5F4 nearly isogenic lines (NILs) that were derived from a cross between the Korean japonica cultivar Hwayeongbyeo and Oryza rufipogon, we demonstrated that 2 QTLs, qSPP5 for spikelets per panicle (SPP) and qTGW5 for grain weight (TGW), are tightly linked on chromosome 5. Alleles from the O. rufipogon parent increased the SPP and decreased TGW in the Hwayeongbyeo background. qSPP5 was located within a 803-kb interval between the simple sequence repeat (SSR) markers INDEL3 and RM18076. Based on the map position, qTGW 5 seemed to be the same gene as qSW5, which controls grain morphology. The additive effect of the O. rufipogon allele at qSPP5 was 10–15 SPP, and 33.0% of the phenotypic variance could be explained by the segregation of the SSR marker RM18058. Yield trials with BC5F4 NILs showed that lines that contained a homozygous O. rufipogon introgression at the qSPP5 region out-yielded sibling NILs that contained Hwayeongbyeo DNA by 15.3% and out-yielded the Hwayeongbyeo parent by 7.3%.

Conclusion
Based on the finding that the O. rufipogon allele for the SPP was beneficial in the japonica and indica cultivar backgrounds, the qSPP5 allele could be valuable for improving rice yields. In addition, the NIL populations and molecular markers are useful for cloning qSPP5.
Identification of Independent Susceptible and Protective HLA Alleles in Japanese Autoimmune Thyroid Disease and Their Epistasis
Authors: Ueda Sho , Oryoji Daisuke , Yamamoto Ken , Noh Jaeduk Yoshimura , Okamura Ken , Noda Mitsuhiko , Kashiwase Koichi , Kosuga Yuka , Sekiya Kenichi , Inoue Kaori , Yamada Hisakata , Oyamada Akiko , Nishimura Yasuharu , Yoshikai Yasunobu , Ito Koichi , Sasazuki Takehiko 
Published: November 2013

Background:
Autoimmune thyroid disease (AITD) includes Graves disease (GD) and Hashimoto thyroiditis (HT), which partially share immunological features. Determining the genetic basis that distinguishes GD and HT is a key to understanding the differences between these 2 related diseases.

Aim:
The aims of this study were to identify HLA antigens that can explain the immunopathological difference between GD and HT and to elucidate epistatic interactions between protective and susceptible HLA alleles, which can delineate the distinct function of HLA in AITD etiology.

Design:
We genotyped 991 patients with AITD (547 patients with GD and 444 patients with HT) and 481 control subjects at the HLA-A, HLA-C, HLA-B, DRB1, DQB1, and DPB1 loci. A direct comparison of HLA antigen frequencies between GD and HT was performed. We further analyzed an epistatic interaction between the susceptible and protective HLA alleles in the development of GD and HT.

Results:
We identified 4 and 2 susceptible HLA molecules primarily associated with GD and HT, respectively, HLA-B*35:01, HLA-B*46:01, HLA-DRB1*14:03, and HLA-DPB1*05:01 for GD and HLA-A*02:07 and HLA-DRB4 for HT. In a direct comparison between GD and HT, we identified GD-specific susceptible class II molecules, HLA-DP5 (HLA-DPB1*05:01; Pc = 1.0 × 10−9) and HLA-DR14 (HLA-DRB*14:03; Pc = .0018). In contrast, HLA components on 3 common haplotypes in Japanese showed significant protective effects against the development of GD and HT (HLA-A*24:02-C*12:02-B*52:01-DRB1*15:02-DQB1*06:01-DPB1*09:01 and HLA-A*24:02-C*07:02-B*07:02-DRB1*01:01-DQB1*05:01-DPB1*04:02 haplotypes for GD and HLA-A*33:03-C*14:03-B*44:03-DRB1*13:02-DQB1*06:04-DPB1*04:01 haplotype for GD and HT). Interestingly, the representative protective HLA, HLA-DR13 (HLA-DRB1*13:02), was epistatic to susceptible HLA-DP5 in controlling the development of GD.

Conclusion:
We show that HLA exerts a dual function, susceptibility and resistance, in controlling the development of GD and HT. We also show that the protective HLA allele is partially epistatic to the susceptible HLA allele in GD.
The role of fanning behavior in water exchange by a nest‐guarding benthic fish before spawning
Authors: Meunier Benjamin , White Blake , Corkum Lynda D. 
Published: November 2013

Lay AbstractIn some species of fish, males provide parental care and fan within nests before eggs are deposited. Courtship fanning behavior by the male may serve to advertise to females both his ability to disperse reproductive chemical signals and to ventilate eggs once deposited in the nest. We used a technique, called particle image velocimetry, to visualize and characterize flow both in and out of a nest generated by courting Round Goby males, a bottom‐dwelling fish. Once flow was characterized, we conducted a laboratory experiment to determine if caudal and pectoral fanning behavior was influenced by the presence of a female near the nest. The presence of a single female in the vicinity of the nest had no effect on fanning rates. However, there were significant differences between fanning behavior between types of fins. Fanning by caudal fins (with the tail at the nest entrance) resulted in water being pushed out of the nest. We estimated that caudal fanning currents propagated over a distance of at least 34 cm from the nest entrance (2–3 times the body length of an adult Round Goby). In contrast, fanning by pectoral fins (with the head at the nest entrance) resulted in flow entering the nest. Flow entering the nest was much lower than flow being pushed out of the nest. We speculate that by pumping water out of the nest with their tail, males disperse odors to guide reproductive females to the nest; whereas pectoral fanning serves mainly to ventilate the nest, denoting specialization of these locomotive structures as pumping and water stirring appendages.
Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library
Authors: Wang Xingang , Robertson Anne L. , Li Jingyu , Chai Ruth Jinfen , Haishan Wang , Sadiku Pranvera , Ogryzko Nikolay V. , Everett Martin , Yoganathan Kanagasundaram , Luo Hongbo Robert , Renshaw Stephen A. , Ingham Philip W. 
Published: November 2013

Summary
Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo model - the Tg(mpx:GFP)i114 zebrafish line in which neutrophils are labelled by green fluorescent protein (GFP) - to screen a natural product library for compounds that can affect neutrophil migratory behaviour. Among 1040 fungal extracts screened, two were found to inhibit neutrophil migration. Subfractionation of these extracts identified sterigmatocystin and antibiotic PF1052 as the active components. Using the EZ-TAXIScan chemotaxis assay, both compounds were also found to have a dosage-dependent inhibitory effect on murine neutrophil migration. Furthermore, neutrophils treated with PF1052 failed to form pseudopods and appeared round in shape, suggesting a defect in PI3-kinase (P13K) signalling. We generated a transgenic neutrophil-specific PtdIns(3,4,5)P3 (PIP3) reporter zebrafish line, which revealed that PF1052 does not affect the activation of PI3K at the plasma membrane. In human neutrophils, PF1052 neither induced apoptosis nor blocked AKT phosphorylation. In conclusion, we have identified an antibiotic from a natural product library with potent anti-inflammatory properties, and have established the utility of the mpx:GFP transgenic zebrafish for high throughput in vivo screens for novel inhibitors of neutrophil migration.
Effects of ortho-Phenyl Substitution on Molecular Arrangements of Octadehydrodibenzo[12]annulene
Authors: Hisaki Ichiro , Manabe Noriko , Osaka Keisuke , Saeki Akinori , Seki Shu , Tohnai Norimitsu , Miyata Mikiji 
Published: November 2013

Abstract
To modulate assembly manners of octadehydrodibenzo[12]annulene ([12]DBA) core in solid state, we first synthesized ortho-phenyl-substituted derivative 2 and investigated the effects of the substituents on the molecular stacking manner of the [12]DBA core. [12]DBA 2 yielded four types of crystals, which differ from that of the parent compound: Namely, the guest-free crystal possessing an offset stacking manner (I-GF), the solvate with a edge-to-face arrangement (II), the solvates with zigzag π-stacked arrangements (III and III′), and the solvate with 1D π-stacked columnar arrangements (IV). In the crystals, the phenyl groups contribute to limiting the stacking geometry of the [12]DBA cores and to forming void spaces accommodating various guest species, allowing versatile molecular assembly manners hitherto known for [12]DBA derivatives. We revealed that the crystals showed structure dependent fluorescence and charge carrier behaviors.
Self-Excited Acoustical System for Stress Measurement in Mass Rocks
Authors: Kwasniewski Janusz , Kravtsov Yury , Dominik Ireneusz , Dorobczynski Lech , Lalik Krzysztof 
Published: November 2013

The paper is devoted to theoretical end experimental studies of the low-frequency Self-excited Acoustical System (SAS), which allows monitoring stress changes in various elastic media including metals, concrete and mass rocks. The main principle of the SAS system is using a vibration exciter and vibration receiver placed on a sample with a positive feedback, which causes the excitation of the system. Stress changes manifest themselves in small but detectable variations of resonance frequency which can be used to indirectly measure stress changes in the material. In the paper the considerations concerning working frequency of SAS were performed. It was suggested that in the case of stress variation in mass rock monitoring, the low frequency (even infrasound) band should be selected, in contrast to the stress monitoring in columns of marble or concrete, where frequencies from an acoustic band should be used. Computer simulations conducted in the MATLAB-Simulink environment were based on the research performed in the laboratories. They focused on finding a relationship between the compressing force and velocity of sound in a specimen made of concrete. Results of the simulations allowed to state that the frequency of self-excited oscillations of simulated SAS change linearly with the pressing force. In the next step the laboratory experiments were carried out. The impact on stress measurement parameters such as: the position of sensors, actuator, and the influence of geometrical shape and dimensions of the sample. A sample of sandstone compressed in a frame by a hydraulic press was used in the study. The results proved the applicability of the design system. Additionally, the new possible applications of SAS were suggested, such as monitoring stress variations of stresses in mass rock, particularly in the active seismic zones.
The basic mechanisms of stimulation and opposition on of intellectual migration processes in the foregn countries
Authors: Куценко  , Kutsenko Tatyana 
Published: November 2013

In the article are briefly described sources and basic approaches
to the regulation of international intellectual migration in the
historical retrospective. It is refined the volume of the concept of term
«international intellectual migration».
Primary attention is given to the analysis of the acting mechanisms of
stimulation and opposition to migration of intellectual personnel in the
foreign countries and Russia.
In the conclusion the possible scenarios of further development of phenomenon
are represented; are proposed the directions of opposition to
mass intellectual emigration from Russia and interaction with the Russian
scientific association abroad.
Formation of competence of high school students at the stage "high school — college"
Authors: Стуловская  , Stulovskaya Natalya 
Published: November 2013

In developing societies the educational system must prepare
educated, moral, and enterprising people who are able not only to live in
civil society, but also to create a society. The solution of these problems is
possible through a radical change in educational content based on the
competency approach.
Bone transport with an external fixator and a locking plate for segmental tibial defects
Authors: Oh C-W. , Apivatthakakul T. , Oh J-K. , Kim J-W. , Lee H-J. , Kyung H-S. , Baek S-G. , Jung G-H. 
Published: November 2013

Although gradual bone transport may permit the restoration of large-diameter bones, complications are common owing to the long duration of external fixation. In order to reduce such complications, a new technique of bone transport involving the use of an external fixator and a locking plate was devised for segmental tibial bone defects.A total of ten patients (nine men, one woman) with a mean age at operation of 40.4 years (16 to 64) underwent distraction osteogenesis with a locking plate to treat previously infected post-traumatic segmental tibial defects. The locking plate was fixed percutaneously to bridge proximal and distal segments, and was followed by external fixation. After docking, percutaneous screws were fixed at the transported segment through plate holes. At the same time, bone grafting was performed at the docking site with the external fixator removed.The mean defect size was 5.9 cm (3.8 to 9.3) and mean external fixation index was 13.4 days/cm (11.8 to 19.5). In all cases, primary union of the docking site and distraction callus was achieved, with an excellent bony result. There was no recurrence of deep infection or osteomyelitis, and with the exception of one patient with a pre-existing peroneal nerve injury, all achieved an excellent or good functional result.With short external fixation times and low complication rates, bone transport with a locking plate could be recommended for patients with segmental tibial defects.Cite this article: Bone Joint J 2013;95-B:1667–72.
Predictors of outcomes of recovery following total hip replacement surgery
Authors: McHugh G. A. , Campbell M. , Luker K. A. 
Published: November 2013

Objectives To investigate psychosocial and biomedical outcomes following total hip replacement (THR) and to identify predictors of recovery from THR. Methods Patients with osteoarthritis (OA) on the waiting list for primary THR in North West England were assessed pre-operatively and at six and 12 months post-operatively to investigate psychosocial and biomedical outcomes. Psychosocial outcomes were anxiety and depression, social support and health-related quality of life (HRQoL). Biomedical outcomes were pain, physical function and stiffness. The primary outcome was the Short-Form 36 (SF-36) Health Survey Total Physical Function. Potential predictors of outcome were age, sex, body mass index, previous joint replacement, involvement in the decision for THR, any comorbidities, any complications, type of medication, and pre-operative ENRICHD Social Support Instrument score, Hospital Anxiety and Depression scores and Western Ontario and McMaster Universities osteoarthritis index score. Results The study included 206 patients undergoing THR. There were 88 men and 118 women with a mean age of 66.3 years (sd 10.4;36 to 89). Pain, stiffness and physical function, severity of OA, HRQoL, anxiety and depression all improved significantly from pre-operative to 12-month assessment (all p < 0.001), with the greatest improvement occurring in the first six months (all p < 0.001). The predictors that were found to influence recovery six months after THR were: pain (p < 0.001), anxiety (p = 0.034), depression (p = 0.001), previous joint replacement (p = 0.006) and anti-inflammatory drugs (p = 0.012). Conclusions The study identified the key psychosocial and biomedical predictors of recovery following THR. By identifying these predictors, we are able to identify and provide more support for patients at risk of poor recovery following THR. Cite this article: Bone Joint Res 2013;2:248–54.
Neubau des Library & Learning Center (LC) an der Wirtschaftsuniversität Wien
Authors: Werner Klaus Ulrich 
Published: November 2013

Zusammenfassung
Der Neubau des Library & Learning Centers der Wirtschaftsuniversität Wien wurde am 7. November 2013 offiziell eröffnet. Beschrieben werden die Grundstruktur sowie die wesentlichen baulichen und funktionalen Merkmale dieses architektonisch ungewöhnlichen Gebäudes.
Application of Finite Element Method for Modeling of Multi-tube Fixed Bed Catalytic Reactors
Authors: Roohi Parham , Alizadeh Reza , Fatehifar Esmaeil , Salami Hosseini Mehdi 
Published: November 2013

Abstract
In this article, the finite element method (FEM) was applied for modeling of multi-tube fixed bed catalytic reactor (FBCR). For this purpose, a more sophisticated 2D pseudo-heterogeneous model was used to calculate steady-state temperature and partial pressure profiles through the reactor. This model has a vast capability in the prediction of temperature and partial pressure distribution, separately, in the fluid and catalyst phases. The finite element results were compared with de wasch and Froment’s numerical work which developed for a well-established reaction in the multi-tube FBCR (o-xylene partial oxidation). The R-squared analysis indicated that the FEM results agree favorably with finite difference results which reported in the literature. Numerical solution coincidence of FEM and FDM increases with reduction of inlet gas temperature. The results show that the finite element as a powerful numerical method can be used to describe the multi-tube fixed bed catalytic reactor.