bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging with engagement: how UK business schools could meet the innovation challenge
Authors: Thorpe Richard , Rawlinson Richard 
Published: May 2014

Purpose– The purpose of this paper is to explore how business schools can better engage with business practice, building on literature that highlights their lack of impact and questions their business-model sustainability. Reporting exemplars of good practice in engagement (in both research and teaching), the paper offers six recommendations for Deans of business schools, government, and businesses.Design/methodology/approach– The research was undertaken for a report commissioned by the Association of Business Schools for the Minister of State for Universities and Science. Methods included a review of published literature; surveys of practising managers, managers who had changed careers to work in business schools, managers who had taken MBA degrees, doctoral students, deans of business schools, and fellows of learned societies; and interviews with individuals close to government who were themselves preparing reports on shaping government policy for business development and economic growth. Examples of good practice were examined for both content and lessons on how they developed.Findings– Six recommendations are proposed, on programme design; faculty skills and experience; developing partnerships and relationships; assessing impact; managing and organizing research; and differentiating business-school offerings for enhanced profile and distinctiveness. Two further crosscutting themes relate to the incentives that might be required for change to happen, and the capabilities needed for delivery.Originality/value– Originality in the paper stems from its focus on the solutions to the problems identified, as opposed to the restatement of the problems themselves.
Experimental study on condition assessment of reinforced concrete structure using a dynamics response approach
Authors: Pong Sing Chun , Love P.E.D. , Davis P.R. 
Published: May 2014

Purpose
– Condition assessment on reinforced concrete (RC) structures is one of the critical issues as a result of structure degradation due to aging in many developed countries. The purpose of this paper is to examine the sensitivity and reliability of the conventional dynamic response approaches, which are currently applied in the RC structures. The key indicators include: natural frequency and damping ratio. To deal with the non-linear characteristics of RC, the concept of random decrement is applied to analyze time domain data and a non-linear damping curve could be constructed to reflect the condition of RC structure.

Design/methodology/approach
– A full-scale RC structure was tested under ambient vibration and the impact from a rubber hammer. Time history data were collected to analyze dynamics parameters such as natural frequency and damping ratio.

Findings
– The research demonstrated that the measured natural frequency is not a good indicator for integrity assessment. Similarly, it was revealed that the traditional theory of viscous damping performed poorly for the RC with non-linear characteristics. To address this problem, a non-linear curve is constructed using random decrement and it can be used to retrieve the condition of the RC structure in a scientific manner.

Originality/value
– The time domain analysis using random decrement can be used to construct a non-linear damping curve. The results from this study revealed that the damage of structure can be reflected from the changes in the damping curves. The non-linear damping curve is a powerful tool for assessing the health condition of RC structures in terms of sensitivity and reliability.
Making the business of “doing good” a good business
Authors: Lam Miranda , Desmarais Edward 
Published: May 2014

Synopsis
Bonnie CLAC (car loans and counseling) is a social entrepreneurship venture whose mission was to help low-to-moderate income consumers purchase new cars. Co-founder and social entrepreneur, Robert Chambers developed a business proposal for the venture. Chambers was struggling to convince banks that the proposal significantly reduced the banks' risks and the proposal provided significant benefits to the banks and community at large. The case begins with another bank rejecting the business proposal, continues with an explanation of the issues sub-prime consumers (generally low-to-moderate income consumers) face when attempting to obtain financing for reliable automobile transportation, and concludes with Chambers beginning to revise his proposal to convince risk averse bankers that Bonnie CLAC's clients were credit worthy and worth the risk. The exhibits for the case are the principal information sources students will use to answer the ice breaker and discussion questions.

Research methodology
The authors developed the case from interviews with Robert Chambers and secondary sources.

Relevant courses and levels
Personal finance, Financial management, Financial institutions management

Theoretical basis
Personal financial planning, Bank lending decisions and Credit scores
Antihypertensive and vascular remodelling effects of the imperatorin derivative OW1 in renovascular hypertension rats
Authors: Zhou Nan , Wang Tao , Song Jia , He Huaizhen , He Jianyu , He Langchong 
Published: May 2014

SummaryOW1 is a novel imperatorin derivative that exhibits vasodilator activity. In the present study, the antihypertensive effect of and inhibition of vascular remodelling by OW1 were investigated in two‐kidney, one‐clip (2K1C) renovascular hypertensive rats. Rats were subjected to the 2K1C procedure and treated with OW1 (40 or 80 mg/kg per day) for 8 weeks. Blood pressure was measured in conscious rats. Microalbumin (mALB) and total protein (U‐TP) concentrations were determined in the urine, as were plasma concentrations of angiotensin (Ang) II, calcitonin gene‐related peptide (CGRP) and angiotensin‐converting enzyme 1 (ACE). The unclipped kidney was stained with haematoxylin and eosin and Masson trichrome, whereas aortic sections were stained with Masson trichrome. In addition, OW1‐induced vasodilatation was evaluated in vitro in rat mesenteric and renal arteries. Immunohistochemical analysis was used to quantify collagen I and III expression. OW1 relaxed rat mesenteric and renal arterial rings in vitro. Treatment of 2K1C hypertensive rats with OW1 (40 and 80 mg/kg per day) for 8 weeks significantly decreased blood pressure. In addition, OW1 reduced plasma AngII and ACE concentrations and increased plasma CGRP concentrations. At 80 mg/kg per day, OW1 decreased blood urea nitrogen, mALB and U‐TP levels. Histological analysis revealed that OW1 reduced renal arteriolar thickness and relieved the structural hypertrophic arteries. Moreover, OW1 had an inhibitory effect on vascular remodelling and renal lesions in hypertensive rats. In conclusion, the results suggest that OW1 could potentially be a novel candidate for hypertension intervention.
Antihypertensive and anti‐inflammatory actions of combined azilsartan and chlorthalidone in Dahl salt‐sensitive rats on a high‐fat, high‐salt diet
Authors: Jin Chunhua , O'Boyle Sean , Kleven Daniel T. , Pollock Jennifer S. , Pollock David M. , White John J. 
Published: May 2014

SummaryMetabolic syndrome (MetS) and chronic kidney disease are global health issues. Metabolic syndrome induces hypertension and commonly results in renal damage. The optimal therapy for hypertension in MetS is unknown. Thiazide diuretics are first‐line therapy; however, these drugs may have untoward effects. In the present study we investigated the effects of azilsartan (AZL), chlorthalidone (CLTD) and their combination on blood pressure and renal injury in a rodent model with features of MetS. Dahl salt‐sensitive rats were fed high‐fat (36% fat), high‐salt (4% NaCl) diet. Groups were then treated with vehicle, AZL (3 mg/kg per day), CLTD (5 mg/kg per day) or AZL + CLTD. Mean arterial pressure was recorded continuously by telemetry. After 26 days, rats were killed humanely and their kidneys were harvested for histology. Both AZL and CLTD attenuated the rise in blood pressure compared with vehicle and the combination further reduced blood pressure compared with CLTD alone. All treatments reduced proteinuria and albuminuria. Nephrinuria was prevented only in groups treated with AZL. Nephrinuria was 57% lower and proteinuria was 47% lower with combination therapy compared with AZL alone. All treatments reduced the number of inflammatory cells in the kidney. In conclusion, in our model, AZL and CLTD lower blood pressure and exhibit renal protective effects. Treatment with AZL offers additional protection, as evidenced by lower nephrinuria and plasma monocyte chemoattractant protein‐1 levels. Combination therapy afforded the greatest protective effects and may be the best choice for hypertensive therapy in MetS.
Glial cell line‐derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse
Authors: Barak Segev , Wang Jun , Ahmadiantehrani Somayeh , Ben Hamida Sami , Kells Adrian P. , Forsayeth John , Bankiewicz Krystof S. , Ron Dorit 
Published: May 2014

AbstractModerate social consumption of alcohol is common; however, only a small percentage of individuals transit from social to excessive, uncontrolled alcohol drinking. This suggests the existence of protective mechanisms that prevent the development of alcohol addiction. Here, we tested the hypothesis that the glial cell line‐derived neurotrophic factor (GDNF) in the mesolimbic system [e.g. the nucleus accumbens (Acb) and ventral tegmental area (VTA)] is part of such a mechanism. We found that GDNF knockdown, by infecting rat Acb neurons with a small hairpin RNA (shRNA) targeting the GDNF gene, produced a rapid escalation to excessive alcohol consumption and enhanced relapse to alcohol drinking. Conversely, viral‐mediated overexpression of the growth factor in the mesolimbic system blocked the escalation from moderate to excessive alcohol drinking. To access the mechanism underlying GDNF's actions, we measured the firing rate of dopaminergic (DAergic) neurons in the VTA after a history of excessive alcohol intake with or without elevating GDNF levels. We found that the spontaneous firing rate of DAergic neurons in the VTA was reduced during alcohol withdrawal and that GDNF reversed this alcohol‐induced DA deficiency. Together, our results suggest that endogenous GDNF in the mesolimbic system controls the transition from moderate to excessive alcohol drinking and relapse via reversal of alcohol‐dependent neuro‐adaptations in DAergic VTA neurons.
Systemic treatment of HER2‐positive metastatic breast cancer: A systematic review
Authors: Wilcken Nicholas , Zdenkowski Nicholas , White Michelle , Snyder Ray , Pittman Ken , Mainwaring Paul , Green Michael , Francis Prudence , De Boer Richard , Colosimo Maree , Chua Sue , Chirgwin Jacquie , Beith Jane , Bell Richard 
Published: May 2014

AbstractAimWe aimed to systematically review and summarize data from the available clinical trials that examined the treatment of HER2‐positive metastatic breast cancer.MethodsWe reviewed phase 2 and 3 studies in which an anti‐HER2 agent was used in one or both arms of the study.While formal meta‐analysis was not possible for such a heterogeneous group of trials, resulting forest plots outline some generalizable findings.ResultsThere is strong evidence that the addition of an anti‐HER2 agent to standard chemo‐ or endocrine therapy improves clinically relevant measurable outcomes. There is also consistent evidence that initial treatment with trastuzumab alone (and subsequent use of a cytotoxic) is inferior to the initial combination of trastuzumab plus chemotherapy, and that either T‐DM1 or dual anti‐HER2 agents are superior to single anti‐HER2 agent regimens. There is no strong evidence that the use of more than one cytotoxic agent together with an anti‐HER2 agent confers any benefit over a single cytotoxic, anti‐HER2 combination.ConclusionThis review provides a strong evidence base for current clinical practice with a discussion of treatment in the Australian setting.
Uprooting “Indigeneity” in South Africa's Western Cape: The Plant That Moves
Authors: Ives Sarah 
Published: May 2014

ABSTRACTAmid global concerns about climate change, scientists suggest that South African rooibos tea's indigenous ecosystem may be shifting southward. By 2011, rooibos farmers were beginning to worry that the plant was abandoning its “proper” home and undermining both their livelihoods and their rooted sense of belonging. Using the framework of plant and human mobility to explore the impact of environmental changes on one farming community, I investigate how climate change unsettles not only livelihoods but also social cosmologies. If rooibos's growing range shifts, how will it affect the ways that farmers understand and claim their heritage in connection to this indigenous plant? How does the uprooting of a plant's indigeneity influence ideas about cultural indigeneity as rooted in place? What role can anthropology play in theorizing ecological mobility? In addressing these questions, I contend that understanding the effects of climate change also involves destabilizing the idea of place. By focusing on plant mobility, I articulate a theory of geographical precarity: I imply that people's uncertain claims to belonging in place merged with uncertainty of the rootedness of place itself. I conclude by examining industry efforts to delineate and control where rooibos could “legally” grow through the creation of geographical indications.
Flash visual evoked potentials are not specific enough to identify parieto‐occipital lobe involvement in term neonates after significant hypoglycaemia
Authors: Hu Liyuan , Gu Qiufang , Zhu Zhen , Yang Chenhao , Chen Chao , Cao Yun , Zhou Wenhao 
Published: May 2014

AbstractAimHypoglycaemia is a significant problem in high‐risk neonates and predominant parieto‐occipital lobe involvement has been observed after severe hypoglycaemic insult. We explored the use of flash visual evoked potentials (FVEP) in detecting parieto‐occipital lobe involvement after significant hypoglycaemia.MethodsFull‐term neonates (n = 15) who underwent FVEP from January 2008 to May 2013 were compared with infants (n = 11) without hypoglycaemia or parietal‐occipital lobe injury. Significant hypoglycaemia was defined as being symptomatic or needing steroids, glucagon or a glucose infusion rate of ≥12 mg/kg/min.ResultsThe hypoglycaemia group exhibited delayed latency of the first positive waveform on FVEP. The initial detected time for hypoglycaemia was later in the eight subjects with seizures (median 51‐h‐old) than those without (median 22‐h‐old) (P = 0.003). Magnetic resonance imaging showed that 80% of the hypoglycaemia group exhibited occipital‐lobe injuries, and they were more likely to exhibit abnormal FVEP morphology (P = 0.007) than the controls. FVEP exhibited 100% sensitivity, but only 25% specificity, for detecting injuries to the parieto‐occipital lobes.ConclusionFlash visual evoked potential (FVEP) was sensitive, but not sufficiently specific, in identifying parieto‐occipital lobe injuries among term neonates exposed to significant hypoglycaemia. Larger studies exploring the potential role of FVEP in neonatal hypoglycaemia are required.
The triglyceride to high‐density lipoprotein ratio identifies children who may be at risk of developing cardiometabolic disease
Authors: Bailey Daniel P. , Savory Louise A. , Denton Sarah J. , Davies Ben R. , Kerr Catherine J. 
Published: May 2014

AbstractAimIt is important to develop simple, reliable methods to identify high‐risk individuals who may benefit from intervention. This study investigated the association between the triglyceride to high‐density lipoprotein cholesterol (TG/HDL) ratio and cardiometabolic risk, cardiorespiratory fitness and physical activity in children.MethodsAnthropometric, biochemical parameters, cardiorespiratory fitness and accelerometry determined physical activity were assessed in 155 children (80 girls) from 10 to 14 years of age from Bedfordshire, UK. Participants were grouped into high and low TG/HDL ratio groups, according to published thresholds. MANCOVA and logistic regression were used in the analysis.ResultsCardiometabolic risk factor levels were significantly higher in participants with a high TG/HDL ratio (p < 0.05). The odds of having high waist circumference (OR = 13.99; 95% CI 2.93, 69.25), elevated systolic blood pressure (5.27; 1.39, 20.01), high non‐HDL cholesterol (19.47; 4.42, 85.81) and ≥2 cardiometabolic risk factors (15.32; 3.10, 75.79) were higher in participants with a high TG/HDL ratio. The TG/HDL ratio values were significantly lower in those with high cardiorespiratory fitness (p = 0.01), but there was no association with physical activity.ConclusionThese findings support the use of the TG/HDL ratio to identify children with cardiometabolic risk factors who may be at risk of developing cardiometabolic disease.
Chemotherapy‐Induced Polyneuropathy: Major Agents and Assessment by Questionnaires
Authors: Zedan Ahmed H. , Vilholm Ole J. 
Published: May 2014

AbstractChemotherapy‐induced polyneuropathy (CIPN) is a common, but underestimated, clinical challenge. Incidence varies depending on many factors that are equally as important as the type of chemotherapeutic agent itself. Moreover, the assessment of CIPN is still uncertain, as several of the most frequently used scales do not rely on a formal neurological evaluation and depend on patients’ reports and examiners’ interpretations. Therefore, the aim of this MiniReview was to introduce the most common chemotherapies that cause neuropathy, and in addition to this, highlight the most significant differences between the neuropathic pain scales, which are most commonly used for assessing CIPN.
Biomonitoring and Hormone‐Disrupting Effect Biomarkers of Persistent Organic Pollutants In Vitro and Ex Vivo
Authors: Bonefeld‐Jørgensen Eva C. , Ghisari Mandana , Wielsøe Maria , Bjerregaard‐Olesen Christian , Kjeldsen Lisbeth S. , Long Manhai 
Published: May 2014

AbstractPersistent organic pollutants (POPs) include lipophilic legacy POPs and the amphiphilic perfluorinated alkyl acids (PFAAs). They have long half‐lives and bioaccumulate in the environment, animals and human beings. POPs possess toxic, carcinogenic and endocrine‐disrupting potentials. Endocrine‐disrupting chemicals (EDCs) are compounds that either mimic or block endogenous hormones and thus disrupt the normal hormone homeostasis. Biomonitoring assesses the internal doses of a person to provide information about chemical exposures. Effect biomarkers assess chemicals potential to affect cellular functions in vivo/ex vivo. Human beings are exposed to complex mixtures of chemicals, having individually very different biological potentials and effects. Therefore, the assessment of the combined, integrated biological effect of the actual chemical mixture in human blood is important. In vitro and ex vivo cell systems have been introduced for the assessment of the integrated level of xenobiotic cellular effects in human beings. Ex vivo studies have shown geographical differences in bioaccumulated POP serum levels, being reflected by the combined biomarker effects of the complex mixture extracted from human serum. Xenohormone receptor transactivities can be used as an ex vivo integrated biomarker of POP exposure and effects. Epidemiological and in vitro/ex vivo studies have supported the potential impact of the combined effect of serum POPs on the activity of hormone and/or dioxin receptors as a risk factor for human health. With focus on hormone disruption, this MiniReview will give an update on recent POP‐related endocrine‐disrupting effects in vitro/ex vivo/in vivo and some related genetic data.
New Compounds Hybrids 1H‐1,2,3‐Triazole‐Quinoline Against Plasmodium falciparum
Authors: Boechat Núbia , Ferreira Maria de Lourdes G. , Pinheiro Luiz C. S. , Jesus Antônio M. L. , Leite Milene M. M. , Júnior Carlos C. S. , Aguiar Anna C. C. , de Andrade Isabel M. , Krettli Antoniana U. 
Published: May 2014

Malaria is one of the most prevalent parasitic diseases in the world. The global importance of this disease, current vector control limitations, and the absence of an effective vaccine make the use of therapeutic antimalarial drugs the main strategy to control malaria. Chloroquine is a cost‐effective antimalarial drug with a relatively robust safety profile, or therapeutic index. However, chloroquine is no longer used alone to treat patients with Plasmodium falciparum due to the emergence and spread of chloroquine‐resistant strains, which have also been reported for Plasmodium vivax. However, the activity of 1,2,3‐triazole derivatives against chloroquine‐sensitive and chloroquine‐resistant strains of P. falciparum has been reported in the literature. To enhance the anti‐P. falciparum activity of quinoline derivatives, we synthesized 11 new quinoline‐1H‐1,2,3‐triazole hybrids with different substituents in the 4‐positions of the 1H‐1,2,3‐triazole ring, which were assayed against the W2‐chloroquine‐resistant P. falciparum clone. Six compounds exhibited activity against the P. falciparum W2 clone, chloroquine‐resistant, with IC50 values ranging from 1.4 to 46 μm. None of these compounds was toxic to a normal monkey kidney cell line, thus exhibiting good selectivity indexes, as high 351 for one compound (11).
What do parents need to enhance participation of their school‐aged child with a physical disability? A cross‐sectional study in the Netherlands
Authors: Piškur B. , Beurskens A. J. H. M. , Jongmans M. J. , Ketelaar M. , Smeets R. J. E. M. 
Published: May 2014

AbstractBackgroundThe aim was to provide an overview of the number, domains and priority of needs as expressed by parents in supporting participation of their school‐aged child with a physical disability. Additionally, this study investigated whether the number of needs within each domain is related to the child's gross motor function level, parent's perceived own general health, family socio‐economic status and family type.MethodA cross‐sectional study with a total of 146 participants (84.9% mothers) who completed a survey including the Family Needs Inventory – Paediatric Rehabilitation, the Gross Motor Function Classification System Family Report Questionnaire, the General Health Questionnaire and a demographic questionnaire. A need has been operationalized as ‘a family's, parent's or other family member's expressed desire for information, services and supports related to their family’. Descriptive statistics and correlation analysis were applied.ResultsParents (n = 146; response rate 27%) varied in the number of expressed needs (range 0–124; mean = 35.9; median = 30; SD = 25.6). Highest mean percentage scores were found for the domains ‘Laws, regulations and fees’ (36%), ‘Leisure time’ (35.6%) and ‘Aids, adaptations, facilities and resources’ (33.8%). Seven single needs were expressed by 50% or more of the parents. All domains of needs showed a positive correlation with perceived parental general health. The domains ‘Laws, regulations and fees’, ‘Day care & school’, ‘Emotional and mental support’ and ‘Raising my child’ correlated negatively with family socio‐economic status; and child's gross motor function level correlated positively with the domains ‘Aids, adaptations, facilities and resources’, ‘Practical support at home’ and ‘Leisure time’.ConclusionsAs parents have a major influence on participation of children with a physical disability, meeting their individual needs should become an objective for service providers and policy makers. Family‐centred service might be more effective by putting a greater emphasis on changing the environment.