bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inviscid Incompressible Flows
Authors: Ruban Anatoly I. , Gajjar Jitesh S. B. 
Published: August 2014

Abstract
This chapter starts by formulating the Euler equations and the boundary condition for inviscid flow, namely the impermeability condition on a rigid-body surface. The Bernoulli integral for incompressible flows is derived, as is the Cauchy–Lagrange integral, and Kelvin’s Circulation Theorem is proved. This theorem is used to identify situations where a flow can be treated as potential. Two examples of three-dimensional potential flows are considered: flow past a motionless sphere and flow produced by a sphere moving through stagnant fluid. In this chapter, attention is principally paid to two-dimensional potential flows, for which the flow analysis reduces to finding a suitable analytic function as the complex potential in the complex plane. The method of conformal mapping is discussed in detail and is used to analyse a number of flows, including flows past Joukovskii aerofoils. The chapter concludes by describing Kirchhoff flow, for which purpose free-streamline theory is used.
Acceleration of short and long DNA read mapping without loss of accuracy using suffix array
Authors: Tárraga Joaquín , Arnau Vicente , Martínez Héctor , Moreno Raul , Cazorla Diego , Salavert-Torres José , Blanquer-Espert Ignacio , Dopazo Joaquín , Medina Ignacio 
Published: August 2014

Abstract
HPG Aligner applies suffix arrays for DNA read mapping. This implementation produces a highly sensitive and extremely fast mapping of DNA reads that scales up almost linearly with read length. The approach presented here is faster (over 20× for long reads) and more sensitive (over 98% in a wide range of read lengths) than the current state-of-the-art mappers. HPG Aligner is not only an optimal alternative for current sequencers but also the only solution available to cope with longer reads and growing throughputs produced by forthcoming sequencing technologies.
Availability and implementation: https://github.com/opencb/hpg-aligner.
Contact: jdopazo@cipf.es or imedina@ebi.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
Poretools: a toolkit for analyzing nanopore sequence data
Authors: Loman Nicholas J. , Quinlan Aaron R. 
Published: August 2014

Abstract
Motivation: Nanopore sequencing may be the next disruptive technology in genomics, owing to its ability to detect single DNA molecules without prior amplification, lack of reliance on expensive optical components, and the ability to sequence long fragments. The MinION™ from Oxford Nanopore Technologies (ONT) is the first nanopore sequencer to be commercialized and is now available to early-access users. The MinION™ is a USB-connected, portable nanopore sequencer that permits real-time analysis of streaming event data. Currently, the research community lacks a standardized toolkit for the analysis of nanopore datasets.
Results: We introduce poretools, a flexible toolkit for exploring datasets generated by nanopore sequencing devices from MinION™ for the purposes of quality control and downstream analysis. Poretools operates directly on the native FAST5 (an application of the HDF5 standard) file format produced by ONT and provides a wealth of format conversion utilities and data exploration and visualization tools.
Availability and implementation: Poretools is an open-source software and is written in Python as both a suite of command line utilities and a Python application programming interface. Source code is freely available in Github at https://www.github.com/arq5x/poretools
Contact: n.j.loman@bham.ac.uk and aaronquinlan@gmail.com
Supplementary information: An IPython notebook demonstrating the functionality of poretools is in Github. Complete documentation is available at http://poretools.readthedocs.org.
Gene Expression Profiling of Tumors From Heavily Pretreated Patients With Metastatic Cancer for the Selection of Therapy
Authors: Rebollo Joseba , Sureda Manuel , Martinez Elena Mª. , Fernández-Morejón Francisco J. , Farré José , Muñoz Vicente , Fernández-Latorre Francisco , Manzano Ramón G. , Brugarolas Antonio 
Published: August 2014

Background:
Recently, it has been shown that it is possible to identify tumor profiles of sensitivity for potentially useful drugs, both conventional and experimental, based on whole oligonucleotide microarray gene expression studies in heavily pretreated patients with metastatic solid tumors.

Methods:
Fresh-frozen tumor biopsies for molecular profiling (MP) were obtained from patients with advanced and refractory cancer. Total tumor and control tissue RNA was hybridized to a whole human genome oligonucleotide microarray. Differentially expressed genes interacting with potential therapeutic targets were identified. Results were complemented with DNA sequencing of selected driver genes and with immunohistochemistry and fluorescent “in situ” hybridization. The results were used to guide experimental treatment.

Results:
MP assays led to a potentially active available drug in 91.2% of the patients. The median number of available active drugs per tumor was 5 (range, 1 to 9). Nine treated patients were not evaluable for response. Partial response was observed in 18 patients (33%), stable disease in 22 patients (40%) (clinical benefit rate of 73%), and progression in 15 (27%). Overall median progression-free survival and overall survival were 8 and 13 months, respectively.

Conclusion:
MP-guided therapy is feasible and seems to improve the clinical outcome of extensively pretreated patients but prospective and confirmatory trials are needed.
Emergent Speciation by Multiple Dobzhansky–Muller Incompatibilities
Authors: Paixão Tiago , Bassler Kevin E. , Azevedo Ricardo B. R. 
Published: August 2014

AbstractThe Dobzhansky–Muller model posits that incompatibilities between alleles at different loci cause speciation. However, it is known that if the alleles involved in a Dobzhansky–Muller incompatibility (DMI) between two loci are neutral, the resulting reproductive isolation cannot be maintained in the presence of either mutation or gene flow. Here we show that speciation can emerge through the collective effects of multiple neutral DMIs that cannot, individually, cause speciation—a mechanism we call emergent speciation. We investigate emergent speciation using models of haploid holey adaptive landscapes—neutral networks—with recombination. We find that certain combinations of multiple neutral DMIs can lead to speciation. Furthermore, emergent speciation is a robust mechanism that can occur in the presence of migration, and of deviations from the assumptions of the neutral network model. Strong recombination and complex interactions between the DMI loci facilitate emergent speciation. These conditions are likely to occur in nature. We conclude that the interaction between DMIs may cause speciation.Author SummaryMost species are kept distinct by incompatibilities between the genes they carry. These genetic incompatibilities cause hybrids between the species to have low fitness. Here we propose that combinations of several incompatibilities can collectively cause the origin of species, although they cannot do so acting alone—a mechanism we call emergent speciation. We use flat fitness landscapes with many holes in them to extend the classic Dobzhansky–Muller model, and capture the essence of the phenomenon. We find that emergent speciation can, indeed, occur through the combined effects of multiple genetic incompatibilities. Furthermore, the conditions that facilitate emergent speciation are likely to occur in nature. We conclude that the interaction between genetic incompatibilities may be a root cause of the origin of species.
Heterogeneous housing markets: structural implications for pricing and risk
Authors: A. Borgersen Trond 
Published: August 2014

Purpose– The purpose of this paper is to compare the structure of risk and the structure of pricing in housing markets where the interaction between segments is taken into account with the structures that come about in a housing market approach that ignores this interplay. Knowing how most empirical assessments of whether housing markets are in or out of equilibrium is related to macroeconomic variables and is ignoring the interplay between segments our aim is to highlight the extent to which a homogeneous market framework underestimates pricing and risk in real housing markets.Design/methodology/approach– Framed in terms of a linearized housing market with two segments, the author derives expressions for house prices and house price risk in three scenarios. The author compares the structure of pricing and the structure of risk in a homogeneous housing market with those of two distinct heterogeneous housing markets where segments are linked as well analyzing as how prices and risk responds to shocks.Findings– The author derives expressions for market segment prices and for the house price index in three distinct housing market scenarios and shows how heterogeneous housing market frameworks produce both expressions for house prices and for house price risk, as well as a response in both risk and prices to shocks to demand, that deviate from those of a homogeneous housing market framework. While significantly underestimating house price risk a homogeneous framework might also be taken by surprise of the price response accompanying shocks to demand.Originality/value– The authors' simplistic expressions for house prices and house price risk provides a framework for bringing two distinct theoretical housing market camps onto the same playing field. The approach shows the value added of taking the interplay between market segments into account when analyzing housing market developments.
Homebuyers and the representation of spatial markets by information providers
Authors: J. Dunning Richard , Grayson Andrew 
Published: August 2014

Purpose– The purpose of this paper is to renew a research agenda considering the impact that information providers’ processes are having on the housing market; in particular to develop a research agenda around the role of the Internet in shaping households’ perceptions of the spatial nature of housing markets.Design/methodology/approach– This paper reviews the existing literature. It uses preliminary extensive survey findings about the role of the Internet in housing search to hypothesise ways in which households may be affected by this transition.Findings– Not applicable – other than evidence for the growth in the importance of the Internet in shaping households’ housing search.Practical implications– First, the academy needs to readdress the theory surrounding information acquisition and use insights from economics, sociology and psychology to understand these processes. Second, local authorities and academics should analyse the impact of Internet use on housing market boundaries (and the profound subsequent impact on policy traction). Third, estate agents should reconsider the role of the Internet in shaping housing markets and provide a critical response to the large property search engines.Originality/value– This paper reviews the literature and explores the necessity of a renewed interest in research on the role of information sources in framing and constraining housing search behaviour.
The grabber: making a first impression the Wilsonian way
Authors: Jacobsson Mattias , Hällgren Markus 
Published: August 2014

Purpose– The purpose of this paper is to contribute to the understanding of what a good grabber is and how to construct one. This is done by drawing on the insights provided by Professor Timothy L. Wilson, for whom this paper is written as an “honorary piece.”Design/methodology/approach– The paper is based on a small sample of papers from the 48 journals that have received contributions from Professor Wilson throughout the years. A total of 12 papers have been selected, using a mix of convenience and haphazard sampling. The grabber of each paper has then been analyzed based on its nature and style.Findings– Based on the review and analysis, five different types of grabbers were identified; the quote, the anecdote, the provocative question, the surprise, and the metaphor, each type representing a unique way (and strategy) of creating initial interest.Research limitations/implications– As this paper was intentionally based on a convenience sample, further investigation is needed to establish whether the presented categories have clear validity and/or whether there are additional categories/strategies for how to create good grabbers.Originality/value– Creation of interest is an increasingly important part of everyday academic practice. As the grabber is a rarely addressed phenomenon in academic literature, the presented categories should be of both interest and practical use to academics in most fields.
Asset management policies and guidelines of different states in Australia
Authors: Nateque Mahmood Muhammad , Prasad Dhakal Subas , Brown Kerry , Keast Robyn , Wiewiora Anna 
Published: August 2014

Purpose
– The purpose of this paper is to explore and compare the asset management policies and practices of six Australian states – New South Wales, Victoria, Queensland, South Australia, Western Australia and Tasmania – to improve understanding of the policy context to best shape policy focus and guidelines. Australian state-wide asset management policies and guidelines are an emergent policy domain, generating a substantial body of knowledge. However, these documents are spread across the layers of government and are therefore largely fragmented and lack coherency.

Design/methodology/approach
– The comparative study is based on the thematic mapping technique using the Leximancer software.

Findings
– Asset management policies and guidelines of New South Wales and Victoria have more interconnected themes as compared to other states in Australia. Moreover, based on the findings, New South Wales has covered most of the key concepts in relation to asset management; the remaining five states are yet to develop a comprehensive and integrated approach to asset management policies and guidelines.

Research limitations/implications
– This review and its findings have provided a number of directions on which government policies can now be better constructed and assessed. In doing so, the paper contributes to a coherent way forward to satisfy national emergent and ongoing asset management challenges. This paper outlines a rigorous analytical methodology to inform specific policy changes.

Originality/value
– This paper provides a basis for further research focused on analyzing the context and processes of asset management guidelines and policies.
Effect of public green space on residential property values in Belfast metropolitan area
Authors: McCord J. , McCord M. , McCluskey W. , Davis P.T. , McIlhatton D. , Haran M. 
Published: August 2014

Purpose– The aim of this study is to add to the emerging knowledge base in the UK and be of relevance to land use planners and all stakeholders in property taxation. Urban green open spaces are valuable environmental resources often associated with positive influences for quality of life and property value.Design/methodology/approach– Using a hedonic pricing specification, this paper measures the proximate effect of public green space on residential property value. It examines the relationship between 3,854 residential sales transactions and public green spaces across the Belfast housing market gathered from Land and Property Services throughout the year 2011 showing the percentage effect on property value with respect to distance to public green spaces.Findings– The results show that,ceteris paribus, urban green space has a significant positive impact on proximate residential properties sale price for the terrace and apartment sectors and that terrace and apartment property located closer to public green spaces achieved increases in sale price of up to 49 per cent. Adjacency to green open space produced significant property value premiums in only two of the four housing types analysed, with limited statistically significant proximate effects evident for the detached and semi-detached sectors, a finding which has important social and public policy implications.Originality/value– A number of empirical studies have demonstrated that public green space, such as urban parks, have a positive impact on property values. However, there is a paucity of empirical research on this relationship in the UK. This study serves to address this gap by examining the effect of public green spaces on house price within the medium-sized regional city in the UK.
Consumer responses toward online review manipulation
Authors: Jin Ma Yoon , Lee Hyun-Hwa 
Published: August 2014

Purpose
– This paper aims to explore the effect on consumer responses of firms’ manipulating online reviews based on review valence (positive vs negative) and the relationship between consumer trust and purchase intentions.

Design/methodology/approach
– This study was designed as an experimental study using a scenario method, and data were randomly collected from 2,080 online shoppers in the USA.

Findings
– Findings reveal that the unfair business practice of manipulating online postings considerably undermined consumer trust toward online reviews. Consumer trust in reviews thus seems to be a critical predictor of purchase intentions, which was strengthened even when respondents knew that online reviews were manipulated.

Practical implications
– Companies may thus need to focus on maintaining transparency and truthfulness in online consumer reviews rather than artificially improving ratings scores or feedback levels.

Originality/value
– This study was the first attempt to provide empirical supports that the level of consumer trust in online reviews significantly decreased after consumers were informed that the review content had been manipulated by a company in both the positive and negative conditions. These results also support previous research articulating the negativity effect.
The role of mindfulness in entrepreneurial market analysis
Authors: M. Gordon Jason , King Schaller Tracey 
Published: August 2014

Purpose– The purpose of this paper is to explore mindfulness as a cognitive construct that affects the identification and processing of information during market analysis leading to opportunity evaluation.Design/methodology/approach– This paper draws from theory on entrepreneurial cognition and introduces the concept of mindfulness in market analysis to better understand the entrepreneurial mindset at the opportunity evaluation stage of the value-creation process.Findings– Based on a review of the literature on entrepreneurial cognition and mindfulness at the marketing/entrepreneurship interface, a detailed description of the concept of mindful market analysis is presented. In addition, propositions are developed regarding the moderating effects of mindful market analysis on the relationships between various personal and psychological factors and information processing outcomes related to opportunity evaluation.Originality/value– Much research exists regarding idea creation, entrepreneurial action, opportunity discovery and recognition and entrepreneurial traits. Taking a different approach, this research focuses on opportunity evaluation and the role of market analysis at this stage of the entrepreneurial process. Overall, these contributions help to fulfill the call for more research on the intrapersonal cognitive processes of entrepreneurs and their role in opportunity evaluation.
How to execute mindful marketing? The role of intrafirm network
Authors: Zhu Tao 
Published: August 2014

Purpose– The purpose of this paper is to propose an empirical linkage of intrafirm network characteristics to individual-level mindful marketing (MM).Design/methodology/approach– Based on current literature in network, market orientation and MM research, this paper presents one conceptual model to capture enablers of MM execution with a network approach. The authors identified a pair of antecedent/barrier to MM execution: individual employees’ shared cross-functional tie and firm-level segmentation of the network.Findings– The paper shows that to execute MM, employees possessing more cross-functional ties are more likely to develop higher level of MM. Meanwhile, it was also found that firm-level segmentation of intrafirm network will negatively affect employees in executing MM.Research limitations/implications– The paper shows that to execute MM, employees possessing more cross-functional ties are more likely to develop higher level of MM. Meanwhile, it was also found that firm-level segmentation of intrafirm network will negatively affect employees in executing MM.Practical implications– The proposed empirical linkage shows that a manager shall intervene and help employees to build cross-functional ties in advice network among themselves. Thus, firms are able to effectively maintain mindfulness of people and profit and ensure optimal execution of MM strategy. Meanwhile, they should offset possible negative effects of the advice network due to segmentation at firm level, which provides useful customer information flow throughout the firm.Originality/value– The paper is one of the first attempts to advance and examine the role of intrafirm network in executing the concept of MM. Methodologically, this paper also explores the use of network analysis in discussion of an organizational structure that favors MM.
The mediating role of mindful entrepreneurial marketing (MEM) between production and consumption
Authors: Uslay Can , Erdogan Emine 
Published: August 2014

Purpose– The purpose of this paper is to introduce and explore the tenets of the mindful entrepreneurial marketing (MEM) construct and to illustrate its mediation effect between production and consumption.Design/methodology/approach– Based on the existing mindfulness and entrepreneurial marketing research, this paper explores tenets of MEM and presents a basic taxonomy to identify mindful production and consumption practices, and opportunities for MEM initiatives.Findings– The study proposes that the combination of mindfulness and entrepreneurial marketing approach provides an ideal match where both consumers and mindful producers can become more mindful and prosper. As a new construct, MEM has the potential to alleviate lack of consumption, to create awareness about overconsumption and, ultimately, to enhance societal welfare by increasing the efficiency of markets by enabling more effective usage of society’s resources.Originality/value– This paper is the first study that focuses on the MEM construct. In this respect, the study contributes to mindfulness, mindful marketing, entrepreneurial marketing and the general marketing literature.