bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric validation of the Chinese versions of EQ-5D-Y-3L and the experimental EQ-TIPS in children and adolescents with COVID-19
Authors: Zhou Wenjing , Li Yaqin , Busschbach Jan , Herdman Michael , Yang Zhihao , Lu Yanming 
Published: July 2024

Abstract
Objectives
Respiratory infectious diseases like COVID-19 profoundly impacts the health of children and adolescents, but validated instruments to measure their impacts on health-related quality of life (HRQoL) are lacking. The EQ-5D-Y-3L, widely used for youth HRQoL, now features a Chinese value set. The experimental EQ-TIPS addresses HRQoL assessment for toddlers and infants. This study tested the psychometric properties of both instruments in paediatric COVID-19 patients, and compared the performance of self-complete and proxy EQ-5D-Y-3L.

Methods
This longitudinal study recruited 861 COVID-19 patients aged 0–18 years and their parental caregivers, with 311 dyads completing the follow-up. Digital administration included the EQ-TIPS, the EQ-5D-Y-3L, and Overall Health Assessment (OHA). Controls comprised 231 healthy children. Analysis encompassed known-group validity, child-parent agreement, and responsiveness to change in disease severity and OHA.

Results
COVID-19 children exhibited lower HRQoL than non-infected peers. The EQ-TIPS and the EQ-5D-Y-3L distinguished groups by disease presence, severity and symptoms, showing moderate to good known-group validity (ESs: 0.45–1.39 for EQ-TIPS, 0.44–1.91 for self-complete EQ-5D-Y-3L, and 0.32–1.67 for proxy EQ-5D-Y-3L). Child-parent agreement was moderate to good for EQ-5D-Y-3L (ICC: 0.653–0.823; Gwet’s AC1: 0.470–0.738), and responsiveness was good for both EQ-TIPS Level Sum Score (LSS) (ESs: 1.21–1.39) and EQ-5D-Y-3L index scores (ESs: 1.00–1.16).

Conclusions
This study demonstrates the reliability, validity, and responsiveness of the experimental EQ-TIPS and the EQ-5D-Y-3L in paediatric COVID-19 patients. It is the first evidence of the EQ-TIPS’ responsiveness, supporting its use in assessing the impact of COVID-19 on paediatric HRQoL.
The resistance to anoikis, mediated by Spp1, and the evasion of immune surveillance facilitate the invasion and metastasis of hepatocellular carcinoma
Authors: Zhang Zhengwei , Chen Xiaoning , Li Yapeng , Zhang Feng , Quan Zhen , Wang Zhuo , Yang Yang , Si Wei , Xiong Yuting , Ju Jiaming , Bian Yu , Sun Shibo 
Published: July 2024

AbstractAnoikis-Related Genes (ARGs) lead to the organism manifesting resistance to anoikis and are associated with unfavorable prognostic outcomes across various malignancies.Therefore, it is crucial to identify the pivotal target genes related to anoikis in HCC .We found that ARGs were significantly correlated with prognosis and immune responses in HCC. The core gene, SPP1, notably promoted anoikis resistance and metastasis in HCC through both in vivo and in vitro studies. The PI3K-Akt-mTOR pathway played a critical role in anoikis suppression within HCC contexts. Our research unveiled SPP1’s role in enhancing PKCα phosphorylation, which in turn activated the PI3K-Akt-mTOR cascade. Additionally, SPP1 was identified as a key regulator of MDSCs and Tregs migration, directly affecting their immunosuppressive capabilities.These findings indicate that in HCC, SPP1 promoted anoikis resistance and facilitated immune evasion by modulating MDSCs and Tregs.
Graphical Abstract
Investigating the Effects of Repetitive Paired-Pulse Transcranial Magnetic Stimulation on Visuomotor Training Using TMS-EEG
Authors: Sasaki Ryoki , Hand Brodie J. , Liao Wei-Yeh , Semmler John G. , Opie George M. 
Published: July 2024

AbstractI-wave periodicity repetitive paired-pulse transcranial magnetic stimulation (iTMS) can modify acquisition of a novel motor skill, but the associated neurophysiological effects remain unclear. The current study therefore used combined TMS-electroencephalography (TMS-EEG) to investigate the neurophysiological effects of iTMS on subsequent visuomotor training (VT). Sixteen young adults (26.1 ± 5.1 years) participated in three sessions including real iTMS and VT (iTMS + VT), control iTMS and VT (iTMSControl + VT), or iTMS alone. Motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs) were measured before and after iTMS, and again after VT, to assess neuroplastic changes. Irrespective of the intervention, MEP amplitude was not changed after iTMS or VT. Motor skill was improved compared with baseline, but no differences were found between stimulus conditions. In contrast, the P30 peak was altered by VT when preceded by control iTMS (P < 0.05), but this effect was not apparent when VT was preceded by iTMS or following iTMS alone (all P > 0.15). In contrast to expectations, iTMS was unable to modulate MEP amplitude or influence motor learning. Despite this, changes in P30 amplitude suggested that motor learning was associated with altered cortical reactivity. Furthermore, this effect was abolished by priming with iTMS, suggesting an influence of priming that failed to impact learning.
Authoritarian Neoliberalism and Asylum Seekers: the Silencing of Accounting and Accountability in Offshore Detention Centres
Authors: George Sendirella , Twyford Erin , Tanima Farzana Aman 
Published: July 2024

AbstractThis paper examines how accounting can both entrench and challenge an inhumane and costly neoliberal policy—namely, the Australian government’s offshore detention of asylum seekers. Drawing on Bruff, Rethinking Marxism 26:113–129 (2014) and Smith, Competition & Change 23:192–217 (2019), we acknowledge that the neoliberalism underpinning immigration policies and the practices related to asylum seekers takes anauthoritariantone. Through the securitisation and militarisation of the border, the Australian state politicises and silences marginalised social groups such as asylum-seekers. Studies have exposed accounting as a technology that upholds neoliberalism by representing policy as objective and factual. Curiously, there has been a wilful intention by successive Australian governments to silence the accounting for offshore detention. We seek to demystify thisunaccounting andunaccountability by exploring counter-accounts produced by meso-level organisations that support asylum seekers. We apply a close-reading method in analysing limited governmental accounts and various counter-accounts to demonstrate how counter-accounts give visibility to practices that an authoritarian neoliberal regime has obfuscated. We also reflect on the potential for counter-accounting to foster broader social change by holding the Australian government accountable to moral and ethical standards of care for human life. This paper considers the intersections between accounting and authoritarian neoliberalism and presents counter-accounts as mechanisms that can challenge these neoliberal norms.
KIAA1429 increases FOXM1 expression through YTHDF1–mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma
Authors: Wu Yue , Luo Yi , Yao Xingchen , Shi Xiangjun , Xu Ziyu , Re Jie , Shi Ming , Li Meng , Liu Junpeng , He Youzhi , Du Xinru 
Published: July 2024

Abstract
Objective
Multiple myeloma (MM) is a deadly plasma cell malignancy with elusive pathogenesis. N6-methyladenosine (m6A) is critically engaged in hematological malignancies. The function of KIAA1429, the largest component of methyltransferases, is unknown. This study delved into the mechanism of KIAA1429 in MM, hoping to offer novel targets for MM therapy.

Methods
Bone marrow samples were attained from 55 MM patients and 15 controls. KIAA1429, YTHDF1, and FOXM1 mRNA levels were detected and their correlation was analyzed. Cell viability, proliferation, cell cycle, and apoptosis were testified. Glycolysis-enhancing genes (HK2, ENO1, and LDHA), lactate production, and glucose uptake were evaluated. The interaction between FOXM1 mRNA and YTHDF1, m6A-modified FOXM1 level, and FOXM1 stability were assayed. A transplantation tumor model was built to confirm the mechanism of KIAA1429.

Results
KIAA1429 was at high levels in MM patients and MM cells and linked to poor prognoses. KIAA1429 knockdown restrained MM cell viability, and proliferation, arrested G0/G1 phase, and increased apoptosis. KIAA1429 mRNA in plasma cells from MM patients was positively linked with to glycolysis-enhancing genes. The levels of glycolysis-enhancing genes, glucose uptake, and lactate production were repressed after KIAA1429 knockdown, along with reduced FOXM1 levels and stability. YTHDF1 recognized KIAA1429-methylated FOXM1 mRNA and raised FOXM1 stability. Knockdown of YTHDF1 curbed aerobic glycolysis and malignant behaviors in MM cells, which was nullified by FOXM1 overexpression. KIAA1429 knockdown also inhibited tumor growth in animal experiments.

Conclusion
KIAA1429 knockdown reduces FOXM1 expression through YTHDF1-mediated m6A modification, thus inhibiting MM aerobic glycolysis and tumorigenesis.

Graphical Abstract
KIAA1429 knockdown reduces FOXM1 expression through YTHDF1-mediated m6A modification, thus inhibiting aerobic glycolysis and tumorigenesis in MM
Compact FE for unbounded attribute-weighted sums for logspace from SXDH
Authors: Datta Pratish , Pal Tapas , Takashima Katsuyuki 
Published: July 2024

AbstractThis paper presents the first functional encryption $$(\textsf{FE})$$

(
FE
)

scheme for the attribute-weighted sum functionality that supports the uniform model of computation. In such an scheme, encryption takes as input a pair of attributes (x, z) where x is public and z is private. A secret key corresponds to some weight function f, and decryption recovers the weighted sum f(x)z. In our scheme, both the public and private attributes can be of arbitrary polynomial lengths that are not fixed at system setup. The weight functions are modelled as $$\text {Logspace Turing machines}$$

Logspace Turing machines

. Prior schemes could only support non-uniform Logspace. The proposed scheme is proven adaptively simulation secure under the well-studied symmetric external Diffie–Hellman assumption against an arbitrary polynomial number of secret key queries both before and after the challenge ciphertext. This is the best possible security notion that could be achieved for . On the technical side, our contributions lie in extending the techniques of Lin and Luo [EUROCRYPT 2020] devised for indistinguishability-based payload hiding attribute-based encryption for uniform Logspace access policies and the “three-slot reduction” technique for simulation-secure attribute-hiding for non-uniform Logspace devised by Datta and Pal [ASIACRYPT 2021] to the context of simulation-secure attribute-hiding for uniform Logspace.
Digital education: Mapping the landscape of virtual teaching in higher education – a bibliometric review
Authors: Makda Fatima 
Published: July 2024

Abstract
Virtual teaching gained momentum for its ability to drive education continuity in times of disruption. As a result, the implementation of virtual teaching has piqued the attention of the higher education sector to leverage the affordances of this mode of instructional delivery, even in times of non-disruption. This study aims to conduct a review of virtual teaching in the higher education sector to reveal the key research trends of previous publications and areas of focus for future research. A bibliometric analysis is used to identify the key topics, themes, authors, sources, articles, and existing collaborations. To achieve this, papers indexed in the Scopus database between 2012 and 2023 were examined and analysed using VOSviewer. The findings of the study are provided through a quantitative analysis that gives a high-level overview of virtual teaching in the higher education sector and highlights the key performance indicators for the creation of articles and their citation through tables, graphs, and visualisation maps. The research yielded a total of 5,663 publications, of which 2,635 published articles were included in the analysis. The findings reiterate virtual teaching as a move in the direction of sustainable education as its assists in democratising knowledge. The analysis highlights the multifaceted nature of the research topic on virtual teaching, revealing six distinct yet interconnected thematic clusters. This study provides a holistic picture of virtual teaching in the higher education sector by integrating the analysis results with pertinent reviews of literature and makes recommendations for future research.
Cognitive ability, education, height and body mass index in relation to risk of schizophrenia and mortality following its diagnosis
Authors: Jørgensen Terese Sara Høj , Wium-Andersen Ida Kim , Wium-Andersen Marie Kim , Rozing Maarten Pieter , Jørgensen Martin Balslev , Sørensen Thorkild IA , Osler Merete 
Published: July 2024

AbstractThis study examines the hypotheses that the traits of higher IQ, longer education and taller height are associated with lower risk of death as compared to traits of low IQ, short education, and short height in men with schizophrenia compared to men without schizophrenia. In total, 937,919 men born 1939-59 and 1983–1997 with information from conscription were followed for incident schizophrenia in Danish registries. Higher levels of cognitive ability, longer education, and taller height were associated with fewer cases of schizophrenia. In a sub-sample of 652,368 men with information on body mass index, underweight was associated with more and overweight and obesity were associated with fewer cases of schizophrenia compared with normal weight. Higher cognitive ability, longer education, and taller height were associated with fewer deaths from both natural and unnatural causes in both men with and without schizophrenia. Underweight was associated with more deaths from natural and unnatural causes, whereas overweight and obesity were associated with more deaths from natural causes and fewer deaths from unnatural causes in both groups of men. Due to interaction, tall height and long educational duration were associated with fewer deaths from natural causes, and obesity was associated with fewer deaths from unnatural causes among men with schizophrenia compared to men without. In conclusion, traits in young adulthood are associated with higher mortality in men with and without schizophrenia, but traits of long educational duration and obesity seem to be especially important for lower mortality in men with schizophrenia.
Colonoscopic surveillance in Lynch syndrome: guidelines in perspective
Authors: Castillo-Iturra Joaquín , Sánchez Ariadna , Balaguer Francesc 
Published: July 2024

AbstractLynch syndrome predisposes to a high risk of colorectal cancer and colonoscopy remains the primary preventive strategy. The prevention of colorectal cancer through colonoscopy relies on identifying and removing adenomas, the main precursor lesion. Nevertheless, colonoscopy is not an optimal strategy since post-colonoscopy colorectal cancer remains an important issue. In continuation of a 2021 journal review, the present article seeks to offer an updated perspective by examining relevant articles from the past 3 years. We place recent findings in the context of existing guidelines, with a specific focus on colonoscopy surveillance. Key aspects explored include colonoscopy quality standards, timing of initiation, and surveillance intervals. Our review provides a comprehensive analysis of adenoma-related insights in Lynch syndrome, delving into emerging technologies like virtual chromoendoscopy and artificial intelligence-assisted endoscopy. This review aims to contribute valuable insights into the topic of colonoscopy surveillance in Lynch syndrome.
Elucidating karyological and agro-morphological characteristics of Vicia cassia boiss. and V. aintabensis Boiss. & Hausskn
Authors: Keleş Hüseyin , Tiryaki Iskender 
Published: July 2024

Abstract
This study aimed to determine the karyological characteristics, DNA content, and agro-morphological plant characteristics of Vicia cassia Boiss. and Vicia aintabensis Boiss. & Hausskn. collected from natural flora of Turkiye. The results were also compared with those of Vicia sativa. The main stem length, the numbers of main stem branches per plant, the number of leaves of main stem, the number of leaflets per leaf, the number of grains per pod, the pod width and length as well as thousand seed weight characteristics showed significant variation across the species, with the exception of 50% inflorescences (p < 0.4987) and natural plant heights (p < 0.3276). Karyotype formulas of Vicia cassia, V. aintabensis and V. sativa were determined as 2n = 2x = 14 = 3 m + 1tsat + 1sm + 2t, 2n = 2x = 14 = 1sm + 4st + 2t, and 2n = 2x = 12 = 5st + 1 m, respectively. The genome size of V. aintabensis (17,227.47 Mbp) was 5.26 and 5.01 times larger than V. cassia (3273.85 Mbp) and V. sativa (3435.22 Mpb), respectively. The importance of the karyomorphological data was also evaluated with the morphological evidences.
Psychometric Properties of the Child Behavior Checklist (CBCL) for Ages 6–18 to Identify Autism Spectrum Disorders (ASD) in a Turkish Parent Sample
Authors: Uğurlu Mahir , Sözer Boz Esra , Turgut Sedat 
Published: July 2024

AbstractThe Child Behavior Checklist for ages 6–18 (CBCL/6–18) is broadly used for psycho-educational assessment in identifying children’s behavior problems in special education and psychology. However, the usefulness of the CBCL/6–18 in a Turkish sample still needs to be investigated. The current study aimed to investigate the psychometric properties of the measures of the CBCL/6–18 within a sample of Turkish parents. The psychometric evaluation includes item calibration using the Partial Credit Model (PCM). We analyzed data from 548 parents who have children with autism spectrum disorder. According to the PCM calibration, the results suggested that the Internalizing, Externalizing, and Total Problem subscales were unidimensional and showed local independence successfully. All subscales demonstrated adequate reliability, indicating that the scale distinguishes between children with different behavior problems. The subscales had varying item step ordering, meaning that transitions from one category to second by parent ratings are relatively straightforward. Some items with easy-to-define behavior problems, for example, Item 42 (constipated), were more likely to be endorsed by parents. Consequently, the CBCL/6–18 has adequate psychometric properties for accurately assessing problem behaviors in children based on parent ratings.
Deciphering the role of rapamycin in modulating decidual senescence: implications for decidual remodeling and implantation failure
Authors: Kendirci-Katirci Remziye , Sati Leyla , Celik-Ozenci Ciler 
Published: July 2024

Abstract
Purpose
Physiological decidual senescence promotes embryo implantation, whereas pathological decidual senescence causes many pregnancy pathologies. The aim of this study was to evaluate the effect of rapamycin on decidual cell subpopulations and endometrial function in physiological and induced senescence and to investigate the decidual cell subpopulations present in physiological conditions during early pregnancy and implantation in mice.

Methods
Control, physiological decidualization (0.5 mM cAMP and 1 μM MPA added), and induced senescence (0.1 mM HU added) models with and without 200 nM rapamycin treatment were established using a human endometrial stromal cell line, and decidual cell subpopulations were analyzed by immunofluorescence and flow cytometry. The human extravillous trophoblast cell line AC-1M88 was also cultured in decidualization models, and spheroid expansion analysis was performed. In in vivo studies, decidual cell subpopulations were analyzed by immunofluorescence during early mouse pregnancy.

Results
The results revealed that rapamycin decreased DIO2 and β-GAL expressions in physiological and induced senescence without FOXO1. Notably, in induced senescence, increased fragmentation was observed in AC-1M88 cells, and rapamycin treatment successfully attenuated the fragmentation of spheroids. We showed that the FOXO1-DIO2 signaling axis can trigger decidual senescence during early gestation and days of implantation in mice.

Conclusions
Our study underlines the importance of rapamycin in modulating decidual cell subpopulations and endometrial tissue function during decidual senescence. The information obtained may provide insight into the pathologies of pregnancy seen due to decidual senescence and guide better treatment strategies for reproductive problems.
Accelerated multistep thermal stabilization of polyacrylonitrile fibers using an ethylenediamine pretreatment
Authors: Tunçel Kemal Şahin , Demirel Tuba , Karacan Ismail 
Published: July 2024

AbstractThe polyacrylonitrile multifilament yarn underwent a multistep heat treatment process including stabilization times ranging from 5 to 75 min following impregnation with a 30% ethylenediamine (EDA) aqueous solution. A series of measurements were employed to determine the structure and properties of thermally stabilized PAN samples. These included fiber thickness, fiber density, flame testing, tensile testing, X-ray diffraction, thermal analysis (differential scanning calorimetry and thermogravimetric analysis), and infrared spectroscopy. The results from XRD and IR spectroscopy indicated that the rate of aromatization reactions increased with longer stabilization times. A detailed examination of the XRD curves obtained through curve-fitting procedures suggested a rapid transformation of the original structure into a disordered amorphous phase containing pre-graphitic domains, evidenced by a gradual reduction in the degree of apparent crystallinity of the original PAN sample. The integration of EDA before the thermal stabilization stage significantly reduced the cyclization time of nitrile groups in the PAN polymer structure, thereby accelerating the stabilization reactions. This chemical pretreatment also improved the thermal stability of the samples by promoting oxidative cross-linking of the PAN polymer chains. After a 75 min multistep stabilization, the carbon yield at 1000 °C was 70.5%. Conversion index values, calculated using IR, XRD, and DSC methods, were 98.3%, 94.8%, and 89.5% respectively for the 75 min sample. These findings highlight the importance of EDA in accelerating the formation of an aromatic structure, which is critical for withstanding the high temperatures of subsequent carbonization stages.
Graphical abstract
Enhancement of YBCO superconductivity by chemical surface treatment
Authors: Bennár M. , Španková M. , Talacko M. , Gregor M. , Kronek J. , Chromik Š. 
Published: July 2024

AbstractEven though high-temperature superconductivity in cuprates has been studied for almost 40 years, it remains one of the most puzzling topics in modern physics. It is well known that most of its electrical properties strongly depend on doping and superconducting current is conducted through the CuO2 layers. From a scientific and technological perspective, YBa2Cu3O7−x (YBCO) poses significant challenges due to its low chemical stability, leading to potential alterations in its properties when exposed to various gasses, solvents, and solutions. In our study, we investigated the effects of various solvents on the metal-to-superconductor transition (MST) of YBCO. Additionally, we explored the potential to enhance the MST through exposure to solvents, along with proposing mechanisms to explain this enhancement.