bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualized pleasure-oriented exercise sessions, exercise frequency, and affective outcomes: a pragmatic randomized controlled trial
Authors: Teixeira Diogo S. , Bastos Vasco , Andrade Ana J. , Palmeira António L. , Ekkekakis Panteleimon 
Published: August 2024

Abstract
Background
Affective responses are increasingly recognized as potentially effective intervention targets that may facilitate exercise and physical activity behavior change. While emerging correlational evidence suggests that more pleasant affective responses are associated with higher participation and adherence, experimental evidence remains scarce. In light of this, we conducted a preregistered, pragmatic, single-blinded, superiority randomized controlled trial with two parallel groups, with the goal of determining the impact of an individualized exercise-intensity prescription targeting pleasure on exercise frequency.

Methods
Forty-seven non-regular exercisers were randomized into two groups. For both groups, the intervention consisted of three exercise sessions based on the Frequency-Intensity-Time-Type (FITT) principle. However, the experimental group also received an individualized intensity prescription based on prior assessment of preference for and tolerance of exercise intensity, as well as instructions emphasizing the promotion of pleasure as a basis for self-regulating exercise intensity. The primary outcome was gymnasium attendance over an eight-week follow-up period. Secondary outcomes were affective valence and arousal, post-exercise enjoyment, core affective exercise experiences, and anticipated and remembered affect.

Results
Forty-six participants were retained for analysis (Mage = 32.00; SD = 8.62 years; 56.5% female). Compared to the control group, the experimental group exhibited 77% higher session attendance (14.35 vs. 8.13 sessions) over the eight-week follow-up period (group main effect p = 0.018, η2p = 0.120; Cohen’s d ranged from 0.28 to 0.91 during follow-up). Also, the experimental group reported higher levels of pleasure during the intervention sessions (for all group main effects, p < 0.001, η2p from 0.33 to 0.37) and higher levels of remembered pleasure (group main effect p = 0.021, η2p = 0.116) and anticipated pleasure (group main effect p = 0.022, η2p = 0.114). No harm was detected.

Conclusions
These results demonstrate the practicality and effectiveness of an intervention aimed at enhancing affective responses to exercise in improving short-term session attendance.

Trial registration
ClinicalTrial.gov NCT05416593.
Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome
Authors: Bouchant Louis , Godet Thomas , Arpajou Gauthier , Aupetitgendre Lucie , Cayot Sophie , Guerin Renaud , Jabaudon Matthieu , Verlhac Camille , Blondonnet Raiko , Borao Lucile , Pereira Bruno , Constantin Jean-Michel , Bazin Jean-Etienne , Futier Emmanuel , Audard Jules 
Published: August 2024

Abstract

Background
Trunk inclination in patients with Acute Respiratory Distress Syndrome (ARDS) in the supine position has gained scientific interest due to its effects on respiratory physiology, including mechanics, oxygenation, ventilation distribution, and efficiency. Changing from flat supine to semi-recumbent increases driving pressure due to decreased respiratory system compliance. Positional adjustments also deteriorate ventilatory efficiency for CO2 removal, particularly in COVID-19-associated ARDS (C-ARDS), indicating likely lung parenchyma overdistension. Tilting the trunk reduces chest wall compliance and, to a lesser extent, lung compliance and transpulmonary driving pressure, with significant hemodynamic and gas exchange implications.

Methods
A prospective, pilot physiological study was conducted on early ARDS patients in two ICUs at CHU Clermont-Ferrand, France. The protocol involved 30-min step gradual verticalization from a 30° semi-seated position (baseline) to different levels of inclination (0°, 30°, 60°, and 90°), before returning to the baseline position. Measurements included tidal volume, positive end-expiratory pressure (PEEP), esophageal pressures, and pulmonary artery catheter data. The primary endpoint was the variation in transpulmonary driving pressure through the verticalization procedure.

Results
From May 2020 through January 2021, 30 patients were included. Transpulmonary driving pressure increased slightly from baseline (median and interquartile range [IQR], 9 [5–11] cmH2O) to the 90° position (10 [7–14] cmH2O; P < 10–2 for the overall effect of position in mixed model). End-expiratory lung volume increased with verticalization, in parallel to decreases in alveolar strain and increased arterial oxygenation. Verticalization was associated with decreased cardiac output and stroke volume, and increased norepinephrine doses and serum lactate levels, prompting interruption of the procedure in two patients. There were no other adverse events such as falls or equipment accidental removals.

Conclusions
Verticalization to 90° is feasible in ARDS patients, improving EELV and oxygenation up to 30°, likely due to alveolar recruitment and blood flow redistribution. However, there is a risk of overdistension and hemodynamic instability beyond 30°, necessitating individualized bed angles based on clinical situations.

Trial registration ClinicalTrials.gov registration number NCT04371016, April 24, 2020.
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Authors: Lukyanchuk Alexandra , Muraki Naomi , Kawai Tomoko , Sato Takehiro , Hata Kenichiro , Ito Tsuyoshi , Tajima Atsushi 
Published: August 2024

Abstract
Background
Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approximately one-third of the vehicles worldwide use diesel, there are growing concerns about the risks posed by DEP to human health. Long-term exposure to DEP is associated with airway hyperresponsiveness, pulmonary fibrosis, and inflammation; however, the molecular mechanisms behind the effects of DEP on the respiratory tract are poorly understood. Such mechanisms can be addressed by examining transcriptional and DNA methylation changes. Although several studies have focused on the effects of short-term DEP exposure on gene expression, research on the transcriptional effects and genome-wide DNA methylation changes caused by long-term DEP exposure is lacking. Hence, in this study, we investigated transcriptional and DNA methylation changes in human adenocarcinoma alveolar basal epithelial A549 cells caused by prolonged exposure to DEP and determined whether these changes are concordant.

Results
DNA methylation analysis using the Illumina Infinium MethylationEPIC BeadChips showed that the methylation levels of DEP-affected CpG sites in A549 cells changed in a dose-dependent manner; the extent of change increased with increasing dose reaching the statistical significance only in samples exposed to 30 µg/ml DEP. Four-week exposure to 30 µg/ml of DEP significantly induced DNA hypomethylation at 24,464 CpG sites, which were significantly enriched for DNase hypersensitive sites, genomic regions marked by H3K4me1 and H3K27ac, and several transcription factor binding sites. In contrast, 9,436 CpG sites with increased DNA methylation levels were significantly overrepresented in genomic regions marked by H3K27me3 as well as H3K4me1 and H3K27ac. In parallel, gene expression profiling by RNA sequencing demonstrated that long-term exposure to DEP altered the expression levels of 2,410 genes, enriching 16 gene sets including Xenobiotic metabolism, Inflammatory response, and Senescence. In silico analysis revealed that the expression levels of 854 genes correlated with the methylation levels of the DEP-affected cis-CpG sites.

Conclusions
To our knowledge, this is the first report of genome-wide transcriptional and DNA methylation changes and their associations in A549 cells following long-term exposure to DEP.
Evolution of Einkorn wheat centromeres is driven by the mutualistic interplay of two LTR retrotransposons
Authors: Heuberger Matthias , Koo Dal-Hoe , Ahmed Hanin Ibrahim , Tiwari Vijay K. , Abrouk Michael , Poland Jesse , Krattinger Simon G. , Wicker Thomas 
Published: August 2024

Abstract
Background
Centromere function is highly conserved across eukaryotes, but the underlying centromeric DNA sequences vary dramatically between species. Centromeres often contain a high proportion of repetitive DNA, such as tandem repeats and/or transposable elements (TEs). Einkorn wheat centromeres lack tandem repeat arrays and are instead composed mostly of the two long terminal repeat (LTR) retrotransposon families RLG_Cereba and RLG_Quinta which specifically insert in centromeres. However, it is poorly understood how these two TE families relate to each other and if and how they contribute to centromere function and evolution.

Results
Based on conservation of diagnostic motifs (LTRs, integrase and primer binding site and polypurine-tract), we propose that RLG_Cereba and RLG_Quinta are a pair of autonomous and non-autonomous partners, in which the autonomous RLG_Cereba contributes all the proteins required for transposition, while the non-autonomous RLG_Quinta contributes GAG protein. Phylogenetic analysis of predicted GAG proteins showed that the RLG_Cereba lineage was present for at least 100 million years in monocotyledon plants. In contrast, RLG_Quinta evolved from RLG_Cereba between 28 and 35 million years ago in the common ancestor of oat and wheat. Interestingly, the integrase of RLG_Cereba is fused to a so-called CR-domain, which is hypothesized to guide the integrase to the functional centromere. Indeed, ChIP-seq data and TE population analysis show only the youngest subfamilies of RLG_Cereba and RLG_Quinta are found in the active centromeres. Importantly, the LTRs of RLG_Quinta and RLG_Cereba are strongly associated with the presence of the centromere-specific CENH3 histone variant. We hypothesize that the LTRs of RLG_Cereba and RLG_Quinta contribute to wheat centromere integrity by phasing and/or placing CENH3 nucleosomes, thus favoring their persistence in the competitive centromere-niche.

Conclusion
Our data show that RLG_Cereba cross-mobilizes the non-autonomous RLG_Quinta retrotransposons. New copies of both families are specifically integrated into functional centromeres presumably through direct binding of the integrase CR domain to CENH3 histone variants. The LTRs of newly inserted RLG_Cereba and RLG_Quinta elements, in turn, recruit and/or phase new CENH3 deposition. This mutualistic interplay between the two TE families and the plant host dynamically maintains wheat centromeres.
Reversible anonymization for privacy of facial biometrics via cyclic learning
Authors: Xu Shuying , Chang Ching-Chun , Nguyen Huy H. , Echizen Isao 
Published: August 2024

AbstractFacial recognition systems have emerged as indispensable components in identity verification. These systems heavily rely on facial data, which is stored in a biometric database. However, storing such data in a database raises concerns about privacy breaches. To address this issue, several technologies have been proposed for protecting facial biometrics. Unfortunately, many of these methods can cause irreversible damage to the data, rendering it unusable for other purposes. In this paper, we propose a novel reversible anonymization scheme for face images via cyclic learning. In our scheme, face images can be de-identified for privacy protection and reidentified when necessary. To achieve this, we employ generative adversarial networks with a cycle consistency loss function to learn the bidirectional transformation between the de-identified and re-identified domains. Experimental results demonstrate that our scheme performs well in terms of both de-identification and reidentification. Furthermore, a security analysis validates the effectiveness of our system in mitigating potential attacks.
Experimental Investigations on Tensile and Shear Behavior of the Interface Between UHP-ECC and Concrete
Authors: Zeng Jun-Jie , Lin Xin-Chao , Feng Sheng-Zhao , Zhu Jiong-Yi , Zhuge Yan , Yan Yihang 
Published: August 2024

AbstractUltra-high performance engineered cementitious composite (UHP-ECC), which is known for its exceptional compressive strength, tensile strength, and ductility, has been emerged as a promising option for repairing and strengthening reinforced concrete (RC) structures. The bond between UHP-ECC and normal concrete is the key issue for the material to be successfully implemented. This paper presents an experimental investigation focused on understanding the tensile and shear behavior of the bonding interface between UHP-ECC and concrete. A total of 78 specimens were prepared and tensile splitting tests and push-out tests were carried out. The study examined key parameters including the strength of the concrete substrate, the roughness of the interface, and the moisture condition at the interface. Various failure modes are observed in the specimens under tensile splitting force and direct shear force, and it is found that the influence of the key parameters varied depending on the type of failure mode. In specimens experiencing full interface debonding or interface failure combined with substrate cracks, the roughness of the interface and the moisture degree have a significant impact on the tensile and shear strength. Conversely, in specimens with full substrate disruption, the strength of the substrates plays a more significant role. Additionally, the study reveals that the grooving treatment is highly effective in improving the shear strength of the interface, but its impact on enhancing the tensile strength is comparatively less pronounced. Prediction models for the tensile and shear strength of the interface are established and verified against the test results. The proposed models provide valuable insights into the behavior of the UHP-ECC to concrete interface and can aid in predicting its performance in practical applications.
Characterizing psychopharmacological prescribing practices in a large cohort of adolescents with borderline personality disorder
Authors: Hauryski Sarah , Potts Alexandra , Swigart Alison , Babinski Dara , Waschbusch Daniel A. , Forrest Lauren N. 
Published: August 2024

Abstract
Background
Psychiatric medications are not efficacious for treating borderline personality disorder (BPD), yet many patients with BPD are prescribed multiple psychiatric medications. This study aimed to (1) characterize psychiatric medication prescribing practices in adolescents with BPD and (2) assess whether demographic features are associated with prescribing practices.

Method
This sample was N = 2950 pediatric patients with BPD (ages 10–19) across the U.S. Data came from the NeuroBlu database, which includes data from 30 U.S. healthcare systems and hundreds of hospitals. Poisson regressions and chi-squared tests determined whether gender, race, and ethnicity were associated with (1) number of unique psychiatric medications prescribed and (2) number of unique medication classes prescribed.

Results
Roughly two-thirds (64.85%) of youth were prescribed any medications. Of these youth, 79.40% were prescribed ≥ 2 unique medications and 72.66% were prescribed ≥ 2 unique medications classes. The mean number of unique medications was 3.50 (SD = 2.50). The mean number of unique medication classes was 2.35 (SD = 1.15). The most commonly prescribed medication classes were antidepressants and antipsychotics, which were often prescribed in combination. Poisson regressions showed that boys were prescribed more unique medications (M = 3.67) than girls (M = 3.47). Non-Latinx youth were prescribed significantly more unique medications (M = 44.12) than Latinx youth (M = 3.60, p = .01).

Conclusions
Results characterize psychiatric medication prescribing practices in youth with BPD. Prescribing practices vary by demographics, such that boys and non-Latinx youth are prescribed more medications than girls and Latinx youth, respectively. These demographic differences suggest that prescribers may treat BPD differently based on patient demographic characteristics.
Determination and interpretation of firing temperature in ancient porcelain utilizing thermal expansion analysis
Authors: Li Zhuopeng , Hu Xuan , Jiang Xiaochenyang , Cui Jianfeng 
Published: August 2024

Abstract
This study utilizes a multidisciplinary approach, combining simulation experiments, thermal expansion analysis, XRD, SEM, and physical property assessments to investigate the firing temperature in illitic-kaolinitic porcelain. Our findings indicate that the accuracy of the thermal expansion method depends on both the actual firing temperature and dwell time. When dwell time is uncertain, the method provides a range of possible actual firing temperatures, differing by approximately 100 °C. Remarkably, as the porcelain body nears full vitrification, the determined firing temperature tends to be notably higher. A critical analysis of previous research suggests potential overestimation of ancient kiln temperatures. Additionally, our study highlights the usefulness of bulk density, water absorption, porosity, and mullite content in determining dwell time. Overall, our research offers new insights into ancient porcelain firing processes.
How understanding the limitations and risks of using ChatGPT can contribute to willingness to use
Authors: Al Murshidi Ghadah , Shulgina Galina , Kapuza Anastasiia , Costley Jamie 
Published: August 2024

AbstractGenerative Artificial Intelligence (GAI) holds promise for enhancing the educational experience by providing personalized feedback and interactive simulations. While its integration into classrooms would improve education, concerns about how students may use AI in the class has prompted research on the perceptions related to the intention to implement GAI, such as perceived benefits, limitations and associated risks in teaching and learning practices. This study examines the perceptions of GAI among 366 students in the United Arab Emirates based on survey results. To do that, initially factor analysis was utilized to identify the relevant scales, followed by comparing the mean values for each scale based on the extent of agreement with the statement regarding students' willingness to use ChatGPT. The study revealed a high awareness among respondents regarding the benefits, limitations, and risks of using ChatGPT. The research confirms that awareness of potential benefits is related to the intention to use ChatGPT in the future. Contrary to expectations, a positive relationship was found between awareness of limitations and the intention to use ChatGPT, challenging traditional views that limitations act as barriers. Similarly, awareness of risks is positively related to the willingness to use ChatGPT, suggesting a nuanced relationship between risk perception and technology adoption in education.The current study provides new insights into the importance of informing individuals about the limitations and risks of ChatGPT, in addition to its benefits, as these factors are closely related to making a positive decision regarding its further usage.
On the phase difference of ECH waves obtained from the interferometry observation by the Arase satellite
Authors: Taki Tomoe , Kurita Satoshi , Shinjo Airi , Fukasawa Ibuki , Nakamura Satoko , Kojima Hirotsugu , Kasahara Yoshiya , Matsuda Shoya , Matsuoka Ayako , Miyoshi Yoshizumi , Shinohara Iku 
Published: August 2024

AbstractWe analyzed electrostatic electron cyclotron harmonic waves observed by the interferometry observation mode of the Arase satellite. It is found that the magnitude of the phase difference varies with the satellite spin. The spin dependence of this phase difference was investigated by examining the trend of the spin dependence for the 84 events of interferometry observation of ECH waves. We found that they are divided into two categories. One is that the phase difference tends to show sinusoidal variations as a function of the angle $$\gamma _B$$

γ
B

between the ambient magnetic field projected on the spin plane and the electric field sensor. The other is that the phase difference is close to zero and does not depend on $$\gamma _B$$

γ
B

. A numerical model of interferometry observation of single plane wave is constructed to explain the observed phase differences. We performed the numerical calculations when the background magnetic field was oriented in the direction often observed in the Arase satellite. The result of the calculations shows the wave vector direction relates to the spin angle with the maximum phase difference. Using this relation, we show that it may be possible to estimate the wave vector direction of ECH waves from one-dimensional interferometry data. This is expected to enable more accurate estimates of phase velocity.
Graphical Abstract
Hallmarks of cancer in patients with heart failure: data from BIOSTAT-CHF
Authors: van den Berg P. F. , Yousif L. I. , Markousis-Mavrogenis G. , Shi C. , Bracun V. , Tromp J. , de Wit S. , Appels Y. , Screever E. M. , Aboumsallem J. P. , Ouwerkerk W. , van Veldhuisen D. J. , Silljé H. H. W. , Voors A. A. , de Boer R. A. , Meijers Wouter C. 
Published: August 2024

Abstract
Background
Within cardio-oncology, emerging epidemiologic studies have demonstrated a bi-directional relationship between heart failure (HF) and cancer. In the current study, we aimed to further explore this relationship and investigate the underlying pathophysiological pathways that connect these two disease entities.

Methods
We conducted a post-hoc analysis in which we identified 24 Gene Ontology (GO) processes associated with the hallmarks of cancer based on 92 biomarkers in 1960 patients with HF. We performed Spearman’s correlations and Cox-regression analyses to evaluate associations with HF biomarkers, severity and all-cause mortality.

Results
Out of a total of 24 GO processes, 9 biological processes were significantly associated with adverse clinical outcome. Positive regulation of mononuclear cell proliferation demonstrated the highest hazard for reaching the clinical endpoint, even after adjusting for confounders: all-cause mortality HR 2.00 (95% CI 1.17–3.42), p = 0.012. In contrast, negative regulation of apoptotic process was consistently associated with a lower hazard of reaching the clinical outcome, even after adjusting for confounders: all-cause mortality HR 0.74 (95% CI 0.59–0.95), p = 0.016. All processes significantly correlated with HF biomarkers, renal function and HF severity.

Conclusions
In patients with HF, GO processes associated with hallmarks of cancer are associated with HF biomarkers, severity and all-cause mortality.