bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surrogate markers for cerebral blood flow correlate with [18F]‐fallypride binding potential at dopamine D2/3 receptors in human striatum
Authors: Cumming Paul , Xiong Guoming , Fougère Christian LA , Rominger Axel , Bartenstein Peter , Buchholz Hans‐Georg , Piel Markus , Rösch Frank , Gründer Gerhard , Vernaleken Ingo 
Published: December 2012

AbstractPositron emission tomography (PET) with the high affinity dopamine D2/3 receptor ligand [18F]‐fallypride affords estimates of the binding potential (BPND) in extra‐striatal regions of low receptor abundance, but the sufficient recording time for accurate measurements in striatum has been called into question. We have earlier argued that transient equilibrium measurements are obtained in striatum with [18F]‐fallypride PET recordings of 3 h duration, which may be the practical limit for clinical investigations without interrupted scanning. However, the high extraction fraction of [18F]‐fallypride predicts flow‐dependence of tracer delivery to brain, which may be a source of variance of the apparent BPND in regions of high binding. To test this prediction, we conducted a retrospective analysis of [18F]‐fallypride PET data from a group of 50 healthy volunteers (age 18–58 years [mean ± SD: 32.6 ± 10.6), who had participated in clinical studies without arterial input measurements. We used the initial 120‐s integral (AUC) of the venous confluence (VC) as a surrogate marker for cerebral blood flow (CBF) and tested for correlations between regional estimates of BPND calculated by the simplified reference tissue model (SRTM) and the individual VC‐AUC. The magnitude of BPND in a high binding region (putamen), but not in a low binding region (thalamus) correlated positively with VC‐AUC, suggesting that approximately 9% of the variance in the [18F]‐fallypride BPND in putamen can be attributed to individual differences in this surrogate marker for CBF, a contribution equal in magnitude to the effects of age on BPND in putamen of the present healthy control group. Synapse, 2013. © 2012 Wiley Periodicals, Inc.
A Phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors
Authors: Gordon Michael S. , Mendelson David S. , Gross Mitchell , Uttenreuther-Fischer Martina , Ould-Kaci Mahmoud , Zhao Yihua , Stopfer Peter , Agus David B. 
Published: December 2012

Summary
Background This trial evaluated the safety, tolerability and maximum tolerated dose (MTD) of afatinib, a novel ErbB Family Blocker. Methods In this open-label, dose-escalation Phase I study, afatinib was administered continuously, orally, once-daily for 28 days to patients with advanced or metastatic solid tumors. Dose escalation was performed in a 3 + 3 design, with a starting dose of 10 mg/day (d); doses were doubled for each successive cohort until the MTD was defined. The MTD cohort was expanded to a total of 19 patients. Incidence and severity of adverse events (AEs), antitumor activity and pharmacokinetics were assessed. Results Thirty patients received at least one dose of afatinib. Twenty-nine patients were evaluable for response. Dose-limiting toxicities (DLTs) consisting of Grade 3 diarrhea were observed in two out of three patients treated at 60 mg/d. The MTD was determined at 40 mg/d. The most frequent treatment-related AEs were diarrhea and mucosal inflammation reported in 76.7 % and 43.3 % of patients respectively. Five patients had stable disease with a median progression-free survival of 111 days. No objective responses occurred. Pharmacokinetic data showed no deviation from dose-proportionality and steady-state was reached on Day 8 at the latest. Conclusions Afatinib was well tolerated with manageable side effects when administered once-daily, continuously at a dose of 40 mg.
Novel Synthesis of a New Surfactant 4‐((4‐Bromophenyl)(dodecyl)amino)‐4‐Oxobutanoic Acid Containing a Benzene Ring Using a Copper Catalyst Cross‐Coupling Reaction and its Properties
Authors: Chen Minggui , Hu Xinqi , Fu Meilong 
Published: December 2012

AbstractA new surfactant 4‐((4‐bromophenyl)(dodecyl)amino)‐4‐oxobutanoic acid with a benzene spacer was synthesized via a novel copper catalyzed cross‐coupling reaction. Its structure was confirmed by FTIR, 1H‐NMR, 13C‐NMR and HRMS; its purity was checked by HPLC. Dynamic light scattering and an atomic force microscope showed that it forms an unusual large‐diameter premicellar aggregation below the CMC.
TT-OSL dating of Longyadong Middle Paleolithic site and paleoenvironmental implications for hominin occupation in Luonan Basin (central China)
Authors: Sun Xuefeng , Lu Huayu , Wang Shejiang , Yi Shuangwen , Shen Chen , Zhang Wenchao 
Published: December 2012

AbstractDating middle Pleistocene hominin occupations alongside the reconstruction of paleoenvironments in China between 700 and 100 ka has always been a challenging task. In this paper, we report thermally transferred optically stimulated luminescence (TT-OSL) dating results for a Middle Paleolithic site in the Luonan Basin, central China, which we have named Longyadong Cave. The results suggest that the age of cave infilling and the deposition of sediments outside the cave range between 389 ± 18 and 274 ± 14 ka. These deposits are stratigraphically and geochronologically correlated with the L4 loess and S3 paleosol units of the typical loess–paleosol sequence of the Chinese Loess Plateau, and with Marine Isotope Stages (MIS) 10 to 9, respectively. On the basis of these new ages and the available paleoenvironmental data, it is suggested that the Longyadong hominins might have occupied the site both in glacial and interglacial periods, demonstrating that they coped well with environmental change in this mountainous region in warm/wet and cold/dry climates. The study further implies that the hominins abandoned the Longyadong Cave between 274 ± 14 and 205 ± 19 ka, when it was sealed by alluvial and slope deposits.
THE DANGERS OF USING SAFETY TO EXPLAIN TRANSMISSION FAILURE: A REPLY TO MARTIN SMITH
Authors: Tucker Chris 
Published: December 2012

AbstractMany epistemologists hold that the Zebra Deduction (the animals are zebras, so they aren't cleverly disguised mules) fails to transmit knowledge to its conclusion, but there is little agreement concerning why it has this defect. A natural idea is, roughly, that it fails to transmit because it fails to improve the safety of its conclusion. In his ‘Transmission Failure Explained’, Martin Smith defends a transmission principle which is supposed to underwrite this natural idea. There are two problems with Smith's account. First, Smith's argument for his transmission principle relies on a dubious premise (§1). Second, even if his transmission principle is true, Smith shows neither that it prevents the Zebra Deduction from transmitting knowledge to its conclusion, nor that it secures the natural idea (§2). I suspect that the failures of Smith's account will be instructive for anyone who wants to connect transmission failure with a failure to enhance the safety, reliability or probability of one's conclusion.
THREE FORMS OF INTERNALISM AND THE NEW EVIL DEMON PROBLEM
Authors: Moon Andrew 
Published: December 2012

AbstractThe new evil demon problem is often considered to be a serious obstacle for externalist theories of epistemic justification. In this paper, I aim to show that the new evil demon problem (‘NEDP’) also afflicts the two most prominent forms of internalism: moderate internalism and historical internalism. Since virtually all internalists accept at least one of these two forms, it follows that virtually all internalists face the NEDP. My secondary thesis is that many epistemologists – including both internalists and externalists – face a dilemma. The only form of internalism that is immune to the NEDP, strong internalism, is a very radical and revisionary view – a large number of epistemologists would have to significantly revise their views about justification in order to accept it. Hence, either epistemologists must accept a theory that is susceptible to the NEDP or accept a very radical and revisionary view.
Acceptance and Commitment Therapy (ACT): An Overview for Practitioners
Authors: Bowden Tim , Bowden Sandra 
Published: December 2012

Acceptance and Commitment Therapy (ACT) offers school counsellors a practical and meaningful approach to helping students deal with a range of issues. This is achieved through encouraging psychological flexibility through the application of six key principles. This article describes our introduction to ACT, ACT's application to children and adolescents, and the creation and use of our ACT-based book for young people I Just Want To Be . . . Me!.
Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men
Authors: Gosselin Chantal , Haman François 
Published: December 2012

The effects of epigallocatechin-3-gallate (EGCG) and caffeine on non-shivering thermogenesis (NST) during cold exposure is unknown. The purpose of the present study was to quantify the effects of co-ingesting EGCG and caffeine on the thermogenic responses of a 3 h cold exposure. A total of eight healthy males were exposed to mild cold, using a liquid-conditioned suit perfused with 15°C water, on two occasions and consumed a placebo or an extract of 1600 mg of EGCG and 600 mg of caffeine (Green tea). Thermic, metabolic and electromyographic measurements were monitored at baseline and during the cold exposure. Results showed that the AUC of shivering intensity over the cold exposure period was reduced by approximately 20 % in the Green tea (266 (sem 6) % maximal voluntary contraction (MVC) × min) compared with the Placebo (332 (sem 69) %MVC × min) (P= 0·01) treatments. In contrast, the total AUC for energy expenditure (EE) was approximately 10 % higher in the Green tea (23·5 (sem 1·4) kJ/kg × 180 min) compared with the Placebo (327 (sem 74) kJ/kg 180 min) (P= 0·007) treatments. The decrease in shivering activity combined with an increase in EE, following the ingestion of EGCG and caffeine during the cold exposure, indicates that NST pathways can be significantly stimulated in adult human subjects. The present study provides an experimental approach for human investigations into the potential role of diet and bioactive food ingredients in modulating NST during cold exposure. Stimulating NST pathways in such a manner may also provide important targets in the search of targets for the management of obesity and diabetes.
Patterns of variation in parasite component communities and infracommunities of a littoral fish species from the northern coast of Chile
Authors: Henríquez Vania , González M. Teresa 
Published: December 2012

AbstractThe structure and similarity of the parasite communities of fish can be evaluated at the component community (CC) and infracommunity (IC) levels. Both hierarchical levels have been used to assess parasite variations in fish at large (biogeographic) scales. However, studies evaluating the consistency between these two hierarchical levels at smaller geographical scales are scarce. In this study, the parasite assemblages of 124Paralabrax humeraliscollected by local fishermen by spear fishing at four sites (El Fierro, EF; P. Angamos, PA; Santa María, ISM; San Jorge, BSJ) in northern Chile were compared to assess the variability (or similarity) of their CCs and ICs at a limited geographical scale using multivariate analysis. At the IC level, discriminant analyses showed thatP. humeralisparasite communities varied significantly among sites; 70% of ectoparasite ICs were correctly assigned to each site, but only 55% of helminth parasite ICs were correctly classified. At the CC level, the composition of parasite communities as assessed by correspondence analyses varied significantly between sites.Tagiasp.,Neobenedeniasp. andPhilometrasp. were associated with BSJ, ISM and PA, respectively;Corynosomasp. and most digeneans were associated with both ISM and EF. Analysis of similarities (ANOSIM) showed significant variations in the degree of similarity betweenP. humeralisCCs from different sites, but not between ICs. Variations between CCs from different sites reflect fish population processes (e.g., population age, reproductive segregation) and the particular conditions of their respective habitats, whereas ICs reflect individual host movements. This study demonstrated that, when examined at a limited geographical scale, IC is better than CC at capturing the local pool of parasite assemblages when host populations are spatially segregated. Therefore, in this study, it is demonstrated that at a small geographic scale, CC variations are not reflected by IC, when host population is spatially segregated.
Cognitive remediation improves memory and psychosocial functioning in first-episode psychiatric out-patients
Authors: Lee R. S. C. , Redoblado-Hodge M. A. , Naismith S. L. , Hermens D. F. , Porter M. A. , Hickie I. B. 
Published: December 2012

BackgroundCognitive remediation (CR) is an effective treatment for several psychiatric disorders. To date, there have been no published studies examining solely first-episode psychiatric cohorts, despite the merits demonstrated by early intervention CR studies. The current study aimed to assess the effectiveness of CR in patients with a first-episode of either major depression or psychosis.MethodFifty-five patients (mean age = 22.8 years, s.d. = 4.3) were randomly assigned to either CR (n = 28) or treatment as usual (TAU; n = 27). CR involved once-weekly 2-h sessions for a total of 10 weeks. Patients were comprehensively assessed before and after treatment. Thirty-six patients completed the study, and analyses were conducted using an intent-to-treat (ITT) approach with all available data.ResultsIn comparison to TAU, CR was associated with improved immediate learning and memory controlling for diagnosis and baseline differences. Similarly, CR patients demonstrated greater improvements than TAU patients in psychosocial functioning irrespective of diagnosis. Delayed learning and memory improvements mediated the effect of treatment on psychosocial functioning at a marginal level.ConclusionsCR improves memory and psychosocial outcome in first-episode psychiatric out-patients for both depression and psychosis. Memory potentially mediated the functional gains observed. Future studies need to build on the current findings in larger samples using blinded allocation and should incorporate longitudinal follow-up and assessment of potential moderators (e.g. social cognition, self-efficacy) to examine sustainability and the precise mechanisms of CR effects respectively.
Estimating the heritability of reporting stressful life events captured by common genetic variants
Authors: Power R. A. , Wingenbach T. , Cohen-Woods S. , Uher R. , Ng M. Y. , Butler A. W. , Ising M. , Craddock N. , Owen M. J. , Korszun A. , Jones L. , Jones I. , Gill M. , Rice J. P. , Maier W. , Zobel A. , Mors O. , Placentino A. , Rietschel M. , Lucae S. , Holsboer F. , Binder E. B. , Keers R. , Tozzi F. , Muglia P. , Breen G. , Craig I. W. , Müller-Myhsok B. , Kennedy J. L. , Strauss J. , Vincent J. B. , Lewis C. M. , Farmer A. E. , McGuffin P. 
Published: December 2012

BackgroundAlthough usually thought of as external environmental stressors, a significant heritable component has been reported for measures of stressful life events (SLEs) in twin studies.MethodWe examined the variance in SLEs captured by common genetic variants from a genome-wide association study (GWAS) of 2578 individuals. Genome-wide complex trait analysis (GCTA) was used to estimate the phenotypic variance tagged by single nucleotide polymorphisms (SNPs). We also performed a GWAS on the number of SLEs, and looked at correlations between siblings.ResultsA significant proportion of variance in SLEs was captured by SNPs (30%, p = 0.04). When events were divided into those considered to be dependent or independent, an equal amount of variance was explained for both. This ‘heritability’ was in part confounded by personality measures of neuroticism and psychoticism. A GWAS for the total number of SLEs revealed one SNP that reached genome-wide significance (p = 4 × 10−8), although this association was not replicated in separate samples. Using available sibling data for 744 individuals, we also found a significant positive correlation of R2 = 0.08 in SLEs (p = 0.03).ConclusionsThese results provide independent validation from molecular data for the heritability of reporting environmental measures, and show that this heritability is in part due to both common variants and the confounding effect of personality.
Italian Fascism and the Political Mobilisation of Working-Class Women 1937–43
Authors: WILLSON PERRY 
Published: December 2012

AbstractThe Sezione Operaie e Lavoranti a Domicilio dei Fasci Femminili (Section of the Fascist Women's Groups for Female Workers and Outworkers) is the only one of the three Italian Fascist Party organisations for adult women that has never been studied. Founded in 1937 and recruiting factory workers, outworkers and domestic servants, it achieved a membership of almost a million by the fall of the regime in 1943. A top-down organisation, run by the largely middle-class Fasci Femminili, it offered its membership a mix of social, educational and professional opportunities. This article explores its activities, its organisational structure, the messages it attempted to convey to its membership and the reasons why such large numbers of women joined.
Fantastic Truths, Compelling Lies: Radio Free Europe and the Response to the Slánský Trial in Czechoslovakia
Authors: FEINBERG MELISSA 
Published: December 2012

AbstractThis article examines the coverage by Radio Free Europe (RFE) of the show trial of Rudolf Slánský in 1952 and contrasts this coverage with documents on the response to the trial within Czechoslovakia. RFE aggressively portrayed the trial as a pack of lies and condemned its anti-Semitism as not authentically Czechoslovak. The response within Czechoslovakia was more much nuanced. Most publicly accepted the trial as valid and acted in ways that underscored that acceptance. Within this acceptance, however, they varied from the trial script and brought their own meanings to the story. Those meanings were not always ones that either RFE or Czechoslovak leaders would have recognised as true.
The effects of magnetic separation on cryopreserved bovine spermatozoa motility, viability and cryo-capacitation status
Authors: Faezah S.S.M. , Zuraina F.M.Y , Farah J.H.F. , Khairul O. , Hilwani N.I. , Iswadi M.I. , Fang C.N. , Zawawi I. , Abas O.M. , Fatimah S.I. 
Published: December 2012

SummaryCryopreservation is a technique used to preserve cells for long-time storage. It is widely used in agriculture to store male gametes in liquid nitrogen. The aim of this study was to determine the optimum thawing temperature and time for samples subjected to annexin V magnetic-activated cell sorting (AnMACS) as the sperm preparation technique. Pooled semen samples from three ejaculates were divided into two groups. The treatment group was subjected both to AnMACS and to being cryopreserved, whilst the control group was cryopreserved directly without MACS. Post-thaw analysis was carried out for samples thawed at either 20°C for 13 s, 37°C for 30 s, 40°C for 7 s, 60°C for 6 s or 80°C for 5 s. Sperm kinematics, viability and capacitation status were determined for samples subjected to all thawing temperatures described. Results showed that thawing at 37°C for 13 s for MACS-processed samples was a superior option compared with other thawing procedures; there was a significant difference inP< 0.05 values for curvilinear velocity (VCL μm/s) and sperm straightness (STR %) when samples were thawed at 40°C for 7 s, with fewer capacitated spermatozoa (P< 0.05) when samples were thawed at 37°C for 30 s, 40°C for 7 s or 60°C for 6 s. Hence, we can speculate that the use of AnMACS as the sperm preparation technique can somehow enhance sperm cryosurvival rate after cryopreservation, however the fertilization potential of these cells has yet to be determined.
Using the crowd for readability prediction
Authors: DE CLERCQ ORPHÉE , HOSTE VÉRONIQUE , DESMET BART , VAN OOSTEN PHILIP , DE COCK MARTINE , MACKEN LIEVE 
Published: December 2012

AbstractWhile human annotation is crucial for many natural language processing tasks, it is often very expensive and time-consuming. Inspired by previous work on crowdsourcing, we investigate the viability of using non-expert labels instead of gold standard annotations from experts for a machine learning approach to automatic readability prediction. In order to do so, we evaluate two different methodologies to assess the readability of a wide variety of text material: A more traditional setup in which expert readers make readability judgments and a crowdsourcing setup for users who are not necessarily experts. To this purpose two assessment tools were implemented: a tool where expert readers can rank a batch of texts based on readability, and a lightweight crowdsourcing tool, which invites users to provide pairwise comparisons. To validate this approach, readability assessments for a corpus of written Dutch generic texts were gathered. By collecting multiple assessments per text, we explicitly wanted to level out readers' background knowledge and attitude. Our findings show that the assessments collected through both methodologies are highly consistent and that crowdsourcing is a viable alternative to expert labeling. This is a good news as crowdsourcing is more lightweight to use and can have access to a much wider audience of potential annotators. By performing a set of basic machine learning experiments using a feature set that mainly encodes basic lexical and morpho-syntactic information, we further illustrate how the collected data can be used to perform text comparisons or to assign an absolute readability score to an individual text. We do not focus on optimising the algorithms to achieve the best possible results for the learning tasks, but carry them out to illustrate the various possibilities of our data sets. The results on different data sets, however, show that our system outperforms the readability formulas and a baseline language modelling approach. We conclude that readability assessment by comparing texts is a polyvalent methodology, which can be adapted to specific domains and target audiences if required.
A diet following Finnish nutrition recommendations does not contribute to the current epidemic of obesity
Authors: Kanerva Noora , Kaartinen Niina E , Ovaskainen Marja-Leena , Konttinen Hanna , Kontto Jukka , Männistö Satu 
Published: December 2012

AbstractObjectiveRecently, the general public opinion is that nutritional recommendations promote obesity rather than prevent it. We created the Recommended Finnish Diet Score (RFDS) that illustrates the Finnish nutrition recommendations and assessed whether this score is associated with BMI, waist circumference (WC) and body fat percentage (BF%).DesignCross-sectional study included two phases of the National FINRISK 2007 Study. Diet was assessed using a validated FFQ. Height, weight, WC and BF% were measured, and BMI values were calculated. The RFDS was developed based on the national nutrition recommendations.SettingA large representative sample of the Finnish population.SubjectsMen (n2190) and women (n2530) aged 25–74 years.ResultsThe RFDS was inversely associated with WC in men (OR = 0·48, 95 % CI 0·28, 0·81,P< 0·05) and BF% in both men (OR = 0·44, 95 % CI 0·24, 0·82,P-trend < 0·05) and women (OR = 0·63, 95 % CI 0·37, 1·08,P-trend < 0·05). The inverse association of RFDS and BF% appeared stronger among older age groups (men: OR = 0·21 CI 0·07, 0·64,P-trend < 0·01; women: OR = 0·56, 95 % CI 0·25, 1·27,P-trend < 0·05) and among women with normal BMI (OR = 0·62, 95 % CI 0·36, 1·09,P-trend < 0·05). The RFDS was not associated with BMI.ConclusionsA diet following nutrition recommendations is likely to help to maintain normal WC and BF%. These findings could be useful for dietary counselling and the prevention of obesity.