bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Chemoradiation in Gastric Cancer: Long-term Outcomes and Prognostic Factors from a Single Institution
Authors: Bruixola Gema , Segura Ángel , Díaz-Beveridge Robert , Caballero Javier , Bennis Mohamed Hassan , Palomar Laura , Giménez Alejandra , Mingol Fernando , García-Mora Carmen , Aparicio Jorge 
Published: June 2015

Background Adjuvant chemoradiotherapy (CRT) improves relapse-free (RFS) and overall survival (OS) in patients with resected gastric cancer. However, difficulties in standardizing an optimal surgical approach and a perceived higher toxicity compared with the perioperative approach have limited its widespread application in Europe. The aim of our study was to assess toxicity and long-term outcomes of adjuvant CRT at our institution. Methods A retrospective review (September 2001-January 2012) was completed of patients with resected gastric cancer who received adjuvant CRT (Macdonald regimen). Adverse events and completion rates, RFS and OS were estimated. Univariate and multivariate analyses of prognostic factors for OS were performed. Results Eighty-seven patients were included. Most had diffuse (52%) and locally advanced tumors (stage III-IV; 66.7%). D2 lymphadenectomy was performed in 80.5%. The most frequent grade 3-4 toxicities were gastrointestinal (28%) and stomatitis (20%), with 78.2% completing treatment. With a median follow-up of 115 months, 58.5% had relapsed, most of them distantly. Median RFS and OS were 9 and 24 months, respectively. Univariate analysis showed that performance status, stage and lymph node burden were significant factors for OS. In the multivariate study, only stage and lymph node burden remained as independent OS predictors. Conclusions Our implementation of the Macdonald regimen achieved worse outcomes than those reported in the INT-0116 trial. The rate of distant relapse remains unacceptably high. Higher rate of positive lymph nodes and of diffuse tumors could explain some differences. The use of perioperative chemotherapy, especially in patients with a poorer prognosis, might improve these results.
Ethnic Difference in Risk of Toxicity in Prostate Cancer Patients Treated with Dynamic Arc Radiation Therapy
Authors: Guerra Jose L. Lopez , Matute Raul , Puebla Fernando , Sánchez-Reyes Alberto , Pontes Beatriz , Rubio Cristina , Nepomuceno Isabel , Acevedo Catalina , Isa Nicolas , Lengua Rafael , Praena-Fernandez Juan Manuel , del Campo Eleonor Rivin , Ortiz Maria Jose , Azinovic Ignacio 
Published: June 2015

Aims and background The objective of this study was to assess the influence of ethnicity on toxicity in patients treated with dynamic arc radiation therapy (ART) for prostate cancer (PC). Methods From June 2006 to May 2012, 162 cT1-T3 cN0 cM0 PC patients were treated with ART (primary diagnosis, n = 125; post-prostatectomy/brachytherapy biochemical recurrence, n = 26; adjuvant post-prostatectomy, n = 11) at 2 institutions. Forty-five patients were Latin Americans and 117 were Europeans. The dose prescribed to the prostate ranged between 68 Gy and 81 Gy. Results The median age was 69 years (range 43-87 years). The median follow-up was 18 months (range 2-74 months). Overall, only 3 patients died, none due to a cancer-related cause. Biochemical recurrence was seen in 7 patients. The rates of acute grade 2 gastrointestinal (GI) and genitourinary (GU) toxicities were 19.7% and 17%, respectively. Only 1 patient experienced acute grade 3 GI toxicity, whereas 11 patients (6.7%) experienced acute grade 3 GU toxicity. Multivariate analysis showed that undergoing whole pelvic lymph node irradiation was associated with a higher grade of acute GI toxicity (OR: 3.46; p = 0.003). In addition, older age was marginally associated with a higher grade of acute GI toxicity (OR: 2.10; p = 0.074). Finally, ethnicity was associated with acute GU toxicity: Europeans had lower-grade toxicity (OR: 0.27; p = 0.001). Conclusions Our findings suggest an ethnic difference in GU toxicity for PC patients treated with ART. In addition, we found that ART is associated with a very low risk of severe toxicity and a low recurrence rate.
Stereotactic Ablative Radiotherapy with CyberKnife in the Treatment of Locally Advanced Prostate Cancer: Preliminary Results
Authors: Fan Chao-Yueh , Chao Hsing-Lung , Huang Wen-Yen , Lin Chun-Shu , Chen Chang-Ming , Lo Cheng-Hsiang 
Published: June 2015

Aims and Background Recent clinical reports of stereotactic ablative radiotherapy (SABR) in the treatment of low-risk prostate cancer have been encouraging. Our study evaluates the efficacy and safety of SABR using the CyberKnife system for treating intermediate- to very-high-risk prostate cancer. Methods and Study Design Between May 2010 and June 2013, 31 patients (15 intermediate risk, 14 high risk, and 2 very high risk) without pelvic lymph node metastasis were enrolled retrospectively. The treatment consisted of 37.5 Gy in 5 fractions over 1-2 weeks using CyberKnife SABR. Twenty-five patients (81%) received androgen deprivation therapy (ADT). Biochemical failure was defined using the nadir + 2 criterion. Toxicity was assessed with the Common Terminology Criteria of Adverse Events (version 4). Results The median follow-up was 36 months (range 7-58 months). The median pretreatment prostate-­pecific antigen (PSA) was 13.5 ng/mL (range 4.5-124.0 ng/mL). The median PSA decreased to 0.09 ng/mL (range <0.04-5.38 ng/mL) and 0.12 ng/mL (range <0.04-2.63 ng/mL) at 6 months and 12 months after SABR, respectively. The 3-year biochemical relapse-free survival was 90.2% for all patients, 100% for the intermediate-risk patients, and 82% for the high- and very-high-risk patients (p = 0.186). No patient experienced ≥ grade 3 toxicity. There were 7 acute and 5 late grade 2 genitourinary toxicities and 1 acute and no late grade 2 gastrointestinal toxicity. Conclusions Our preliminary results support that CyberKnife SABR with ADT is safe and feasible in patients with intermediate- to high-risk prostate cancer. A further large-scale clinical trial with longer follow-up is warranted.
Interleukin-6 as a Prognostic Marker for Breast Cancer: A Meta-analysis
Authors: Lin ShuChen , Gan ZhiHua , Han Kun , Yao Yang , Min DaLiu 
Published: June 2015

Aims and background Interleukin-6 (IL-6) has been shown to promote tumor survival, metastasis, and angiogenesis, in addition to possessing antitumor activities. In light of the conflicting data, we sought to determine whether IL-6 could be used as a prognostic factor for patients with breast cancer. Methods Eligible studies describing the use of IL-6 as a prognostic factor for breast cancer were identified. Data describing overall survival (OS), disease-free survival (DFS), and clinicopathologic features were collected and analyzed. Results Thirteen articles containing 3,224 breast cancer patients were identified. The results showed that IL-6 expression was not associated with lymph node metastasis, tumor size, or histologic grade. Moreover, there was no correlation between IL-6 expression and DFS. However, the combined hazard ratio (95% confidence interval) for OS was 2.15 (1.46, 3.17). Sensitivity analysis further demonstrated that, for OS, the results of this meta-analysis were stable. A subgroup analysis showed that the source used to detect IL-6 levels may have altered the pooled results for OS. Conclusions Taken together, these results indicate that IL-6 expression is associated with poor prognosis for breast cancer and the prognostic role is affected by the source used to detect IL-6 levels.
Creating Beauty: The Experience of a Fashion Collection Prepared by Adolescent Patients at a Pediatric Oncology Unit
Authors: Veneroni Laura , Clerici Carlo Alfredo , Proserpio Tullio , Magni Chiara , Sironi Giovanna , Chiaravalli Stefano , Roncari Luisa , Casanova Michela , Gandola Lorenza , Massimino Maura , Ferrari Andrea 
Published: June 2015

Aims and Background Adolescent patients with cancer need psychological support in order to face the traumatic event of cancer diagnosis and to preserve continuity with their normal lives. Creative projects or laboratories may help young patients express their thoughts and feelings. Methods The Youth Project developed activities dedicated to adolescents to give them a chance to vent their creative spirit and express themselves freely. In the first project, the teenagers designed their own fashion collection in all its various stages under the artistic direction of a well-known fashion designer, creating their own brand name (B.Live), and organized a fashion show. Results In all, 24 patients from 15 to 20 years old took part in the project. The fashion project proved a fundamental resource in helping the young patients involved to regain a positive self-image and the feeling that they could take action, both on themselves and in their relations with others. Conclusions Facilitating the experience of beauty may enable hope to withstand the anguish caused by disease. This experience integrated the usual forms of psychological support to offer patients a form of expression and support during the course of their treatment.
Onabotulinumtoxina Intravesical Treatment in Patients Affected by Overactive Bladder Syndrome: Best Practice in Real-Life Management
Authors: Giannantoni Antonella , Proietti Silvia , Costantini Elisabetta , Gubbiotti Marilena , De Vermandois Jacopo Rossi , Porena Massimo 
Published: June 2015

Purpose We evaluated intradetrusorial OnabotulinumtoxinA (Onabot/A) treatment protocols in patients with idiopathic overactive bladder (OAB), in order to assess the care of patients before, during and after treatment. Methods In 64 OAB patients injected with Onabot/A, we reviewed the length of the hospital stay, frequency of catheterization, frequency of intraoperative and postoperative complications, and patients’ satisfaction to the proposed treatment protocol (as assessed by VAS). We also compared the results of the 3-day voiding diary, uroflowmetry with postvoid residual urine (PVR) and VAS to score the bother of urinary symptoms on quality of life (QoL) before and after treatment. Results Twenty-one patients were firstly treated in an ‘inpatient’ setting. The mean ± SD duration of hospitalization and catheterization was 39.4 ± 12.6 and 37.8 ± 10.6 h, respectively. The mean ± SD VAS values of treatment satisfaction and of bother of urinary symptoms on QoL were 6.3 ± 1.1 and 8.2 ± 1.3, respectively. The mean ± SD PVR value was 74.3 ± 15.2 ml. Frequency of UTIs was 2.4 ± 1.6. Forty-three patients were treated on an outpatient basis; the mean ± SD duration of catheterization, the ‘outpatient’ stay and the mean ± SD frequency of UTIs were lower than those of patients treated in an inpatient setting. The mean ± SD VAS value to score QoL was high. Conclusions Intradetrusorial Onabot/A injection is a simple and fast procedure that can be easily carried on in an outpatient setting under local anesthesia, with low rates of intraoperative and postoperative complications.
Accessing the Mind’s Eye and Ear: What Might Lab Experiments Tell Us About Film Music?
Authors: Donnelly K.J. 
Published: June 2015

Abstract
A psychological understanding of film music ought to be based on ideas derived from audiovisual phenomena in human perception and cognition, allied with experiments designed and calibrated specifically for film music rather than jerry-built from the prevailing methods in psychology and scientific analysis. Possibilities now exist for laboratory experimentation, which might change the way we understand film music and the approaches we take to it.
Audiovisual Styling and the Film Experience: Prospects for Textual Analysis and Experimental Approaches to Understand the Perception of Sound and Music in Movies
Authors: Langkjær Birger 
Published: June 2015

AbstractApproaches to music and audiovisual meaning in film appear to be very different in nature and scope when considered from the point of view of experimental psychology or humanistic studies. Nevertheless, this article argues that experimental studies square with ideas of audiovisual perception and meaning in humanistic film music studies in two ways: through studies of vertical synchronous interaction and through studies of horizontal narrative effects. Also, it is argued that the combination of insights from quantitative experimental studies and qualitative audiovisual film analysis may actually be combined into a more complex understanding of how audiovisual features interact in the minds of their audiences. This is demonstrated through a review of a series of experimental studies. Yet, it is also argued that textual analysis and concepts from within film and music studies can provide insights and explanatory frameworks that have not yet been addressed in a sufficient manner by experimental approaches. Three such areas are identified: single film analysis, intramodal interactions, and questions of implied authorship. In these cases, concepts and analytic practices from within film and music studies can provide insights and afford great explanatory value. Accordingly, the point of this article is not only to address how experimental and textual approaches may benefit from each other but also to show that experimental studies of cross-modal interactions need to address issues and pose questions that are more intimately linked with present concerns within humanistic film studies.
Trends in Cervical Cytology Screening and Reporting Practices: Results From the College of American Pathologists 2011 PAP Education Supplemental Questionnaire
Authors: Crothers Barbara A. , Darragh Teresa M. , Tambouret Rosemary H. , Nayar Ritu , Barkan Guliz A. , Zhao Chengquan , Booth Christine Noga , Padmanabhan Vijayalakshmi , Tabatabai Z. Laura , Souers Rhona J. , Thomas Nicole , Wilbur David C. , Moriarty Ann T. 
Published: June 2015

ContextThe College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey.ObjectiveTo provide a cross-sectional survey of gynecologic cytology practices in 2010.DesignIn 2011, a survey was sent to 1604 laboratories participating in the College of American Pathologists gynecologic cytology interlaboratory comparison education program and proficiency testing programs requesting data from 2010 on the following topics: terminology/reporting, cytotechnologist workload, quality assurance, reagents, and ancillary testing.ResultsSix hundred and twenty-five laboratories (39%) replied to the survey. The nonstandard use of “low-grade squamous intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesion” is used by most laboratories to report the presence of low-grade squamous intraepithelial lesion with possibility of high-grade squamous intraepithelial lesion. Most laboratories also report the presence or absence of cells from the transformation zone. Most respondents do not limit cytotechnologist screening workload during the work shift. Only about one-third of laboratories (188 of 582; 32%) use image-assisted screening devices. Rapid prescreening as a quality assurance measure is used by only 3.5% (21 of 594) of the laboratories. When used for screening, most laboratories use the imager for retrospective review of slides to detect human locator and interpretive errors. Most laboratories receive both liquid-based cytology samples (mainly ThinPrep, Hologic, Marlborough, Massachusetts) and conventional Papanicolaou tests. Expiration dates of liquid-based cytology test vials are not usually recorded.ConclusionsThe field of gynecologic cytology is evolving rapidly. These survey results offer a snapshot of national gynecologic cytology practices in 2010.
Instrumentalisation des droits humains en politique étrangère canadienne ?
Authors: Anzueto Marc-André 
Published: June 2015

Les droits humains et les opportunités commerciales sont deux thèmes qui ont historiquement marqué la politique étrangère du Canada à l’égard du Guatemala. En dépit d’une promotion explicite des intérêts économiques canadiens dans le secteur minier et des tensions avec la société civile, pourquoi le gouvernement Harper insiste-t-il sur l’importance des droits humains au Guatemala ? Cet article propose une réflexion théorique sur l’instrumentalisation des droits humains sous le prisme du néoconservatisme et de l’internationalisme en analysant le cas guatémaltèque depuis les années 1980. En fait, l’instrumentalisation des droits humains s’inscrit dans un processus de (re)définition du tandem identité / intérêt national canadien.
Pratiques coopétitives dans l’Open Innovation : Les enseignements des patent pools
Authors: Ayerbe Cécile , Azzam Jamal  Eddine 
Published: June 2015

Cette recherche propose une relecture de l’Open Innovation sous l’angle de la coopétition. Une telle approche est encore très peu appréhendée dans la littérature existante. Ces logiques de coopétition sont analysées dans le cadre des ‘‘patent pools’’ qui constituent une forme organisée d’innovation ouverte que nous qualifions ‘‘d’ouverture à grande échelle’’, très peu étudiée par la littérature managériale. Nous montrons que les patent pools reposent sur le développement simultané de pratiques collaboratives et compétitives, que ce soit lors de leur constitution ou ensuite de leur fonctionnement et en tirons des enseignements quant à la coopétition dans l’Open Innovation.
Risk factors for pre‐term birth in a Canadian cohort of HIV‐positive women: role of ritonavir boosting?
Authors: Kakkar Fatima , Boucoiran Isabelle , Lamarre Valerie , Ducruet Thierry , Amre Devendra , Soudeyns Hugo , Lapointe Normand , Boucher Marc 
Published: June 2015

BackgroundThe risk of pre‐term birth (PTB) associated with the use of protease inhibitors (PIs) during pregnancy remains a subject of debate. Recent data suggest that ritonavir boosting of PIs may play a specific role in the initiation of PTB, through an effect on the maternal–fetal adrenal axis. The primary objective of this study is to compare the risk of PTB among women treated with boosted PI versus non‐boosted PIs during pregnancy.MethodsBetween 1988 and 2011, 705 HIV‐positive women were enrolled into the Centre Maternel et Infantile sur le SIDA mother–infant cohort at Centre Hospitalier Universitaire Sainte‐Justine in Montreal, Canada. Inclusion criteria for the study were: 1) attendance at a minimum of two antenatal obstetric visits and 2) singleton live birth, at 24 weeks gestational or older. The association between PTB (defined as delivery at <37 weeks gestational age), antiretroviral drug exposure and maternal risk factors was assessed retrospectively using logistic regression.ResultsA total of 525 mother–infant pairs were included in the analysis. Among them, PI‐based combination anti‐retroviral therapy was used in 37.4%, boosted PI based in 24.4%, non‐nucleoside reverse transcriptase inhibitor (NNRTI) or nucleoside reverse transcriptase inhibitor based in 28.1%, and no treatment was given in 10.0% of cases. Overall, 13.5% of women experienced PTB. Among women treated with antiretroviral therapy, the risk of PTB was significantly higher among women who received boosted versus non‐boosted PI (OR 2.01, 95% CI 1.02–3.97). This remained significant after adjusting for maternal age, delivery CD4 count, hepatitis C co‐infection, history of previous PTB, and parity (aOR 2.17, 95% CI 1.05–4.51). There was no increased risk of PTB with the use of unboosted PIs as compared to NNRTI‐ or NRTI‐based regimens.ConclusionWhile previous studies on the association between PTB and PI use have generally considered all PIs the same, our results would indicate a possible role of ritonavir boosting as a risk factor for PTB. Further work is needed to understand the pathophysiologic mechanisms involved, and to identify the safest ARV regimens to be used in pregnancy.
Fabrication and evaluation of deep-proton-exchanged and annealed waveguides in MgO:stoichiometric-LiTaO3
Authors: Okazaki Masahide , Chichibu Takao , Yoshimoto Syuhei , Mizuno Hirofumi , Suhara Toshiaki 
Published: June 2015

Abstract
We developed deep-proton exchanged (DPE) and annealed waveguides in MgO:stoichiometric-LiTaO3 crystal. We performed DPE in pyrophosphoric acid at 230 °C for 20 min and measured mode size and depth dependent on the annealing duration. High-quality planar waveguides of a mode size as large as 20 µm, suitable for electro-optic spatial light modulators for 355 nm UV wavelength, were obtained by annealing for 200 h.
The influence of birth season on height: Evidence from indonesia
Authors: Sohn Kitae 
Published: June 2015

AbstractObjectives:Literature on the effect of birth month on height has generally considered regions in temperate climates. However, because many climatic conditions there change with seasons, it is difficult to isolate potential causes. This study estimated the effect of birth month and season on terminal height by analyzing the population of a country with only a few factors driving its climate.Materials and Methods:The sample was derived from nationally representative data of the Indonesian population. We considered 9,262 men and 10,314 women 20–50 years of age. We applied cosinor analysis to a time series of height by birth month. We then applied a more flexible approach by regressing height on a series of dummy variables for birth month (and, subsequently, season) and birth year fixed effects by sex.Results:There was no statistically significant difference in height by birth month. However, although weakly significant, men born in the dry season (June–September) were 2.3 mm shorter than those born in the wet season (the remaining months). The corresponding figure for women was 2.6 mm, a statistically significant difference.Discussion:We eliminated some potential factors previously suggested in the literature, including insolation, the position of our planet with respect to the sun, food availability, and maternal workload. We speculate that babies born in the dry season were affected in the third trimester by the high disease burden that characterizes the wet season. Am J Phys Anthropol 157:659–665, 2015. © 2015 Wiley Periodicals, Inc.
Population‐based study of hospital costs for hospitalizations of infants, children, and adults with a congenital heart defect, Arkansas 2006 to 2011
Authors: Simeone Regina M. , Oster Matthew E. , Hobbs Charlotte A. , Robbins James M. , Collins R. Thomas , Honein Margaret A. 
Published: June 2015

BackgroundCongenital heart defects (CHDs) are common birth defects and are associated with high hospital costs. The objectives of this study were to assess hospitalization costs, across the lifespan, of patients with CHDs in Arkansas.MethodsData from the 2006 to 2011 Healthcare Cost and Utilization Project Arkansas State Inpatient Databases were used. We included hospitalizations of patients whose admission occurred between January 1, 2006, and December 31, 2011, and included a principal or secondary CHD ICD‐9‐CM diagnosis code (745.0–747.49, except 747.0 and 745.5 for preterm infants). Hospitalizations were excluded if they involved out‐of‐state residents, normal newborn births, or if missing data included age at admission, state of residence, or hospital charges. Children were defined as those < 18 years‐old at time of admission.ResultsBetween 2006 and 2011, there were 2,242,484 inpatient hospitalizations in Arkansas. There were 9071 (0.4%) hospitalizations with a CHD, including 5,158 hospitalizations of children (2.2% of hospitalizations among children) and 3,913 hospitalizations of adults (0.2% of hospitalizations of adults). Hospital costs for these CHD hospitalizations totaled $355,543,696. The average annual cost of CHD hospitalizations in Arkansas was $59,257,283 during this time period. Infants accounted for 72% of all CHD‐related hospital costs; total costs of CHD hospitalizations for children were almost five times those of hospitalization costs for adults with CHD.ConclusionHospitalizations with CHDs account for a disproportionate share of hospital costs in Arkansas. Hospitalizations of children with CHD accounted for a higher proportion of total hospitalizations than did hospitalizations of adults with CHD. Birth Defects Research (Part A) 103:814–820, 2015. © 2015 Wiley Periodicals, Inc.