bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural identification of imatinib cyanide adducts by mass spectrometry and elucidation of bioactivation pathway
Authors: Li Austin C. , Yu Erya , Ring Steven C. , Chovan James P. 
Published: November 2013

RATIONALERecent publications have reported that imatinib forms cyanide and methoxylamine adducts in vitro but without detail structural identification. The current work reports the identification of seven cyanide adducts that elucidate the bioactivation pathways and may provide hints for observed clinical adverse effects of the drug.METHODSImatinib was incubated with human liver microsomal proteins in the presence of a NADPH‐regeneration system and the trapping agents reduced GSH, potassium cyanide and methoxylamine. Samples were analyzed by high‐performance liquid chromatography (HPLC) coupled with a LTQ‐Orbitrap data collection system. Chemical structures were determined and/or postulated based on data‐dependent high‐resolution tandem mass spectrometric (MSn) exact mass measurements in both positive and negative scan modes, as well as in combination with hydrogen‐deuterium exchange (HDX).RESULTSGSH and methoxylamine conjugates were either not detected or were in insufficient quantities for characterization. However, seven cyanide conjugates were identified, indicating that the piperazine and p‐toluidine partial structures in imatinib can become bioactivated and subsequently trapped by the nucleophile cyanide ion. The reactive intermediates were postulated as imine and imine‐carbonyl conjugate (α,β‐unsaturated) structures on the piperazine ring, and imine‐methide on the p‐toluidine partial structure.CONCLUSIONSChemical structures of seven cyanide adducts of imatinib have been identified or proposed based on high‐resolution MS/MS data. Mechanisms for the formation of the conjugates were also proposed. The findings may help to understand the mechanism of hepatotoxicity of imatinib in humans. Copyright © 2013 John Wiley & Sons, Ltd.
Reproducibility and accuracy of noble gas measurements on water samples in the microlitre range
Authors: Sander Tim , Marx Thomas , Engel Jürgen , Aeschbach‐Hertig Werner 
Published: November 2013

RATIONALEIn order to derive meaningful noble gas temperatures (NGTs) from speleothem fluid inclusions, precise and accurate measurements of noble gas concentrations on very small water samples are necessary. To optimise these measurements and their reliability, an investigation of the reproducibility and accuracy of the analytical procedure is essential.METHODSWater equilibrated with air under controlled conditions was filled into copper capillaries to produce small (about 1 μL) air‐equilibrated water samples (so‐called μAEWs). As speleothem samples, the μAEWs were opened in a crusher and the released noble gases analysed with an electron ionisation sector field mass spectrometer run in static mode. For better comparability with speleothem samples, a defined amount of air was added to the noble gases derived from one group of μAEWs.RESULTSThe reproducibility of the experimental procedure was found to be better than 2.2% for all relevant noble gases. Within these uncertainties, the measured noble gas concentrations of μAEWs agree with expectations. The corresponding NGTs reproduce within 0.5°C and deviate by less than 1°C from the equilibration temperature. In the case of air addition, the air to water ratio was determined accurately and, excluding one outlier, the NGTs were determined with a reproducibility and accuracy well below 1°C.CONCLUSIONSThe results show that the used measurement procedure is generally suitable to reveal major climatic temperature changes, for which an overall NGT error of less than 1°C is desirable, from very small water samples as obtained from speleothem fluid inclusions. Copyright © 2013 John Wiley & Sons, Ltd.
Passivity and passification of stochastic impulsive memristor‐based piecewise linear system with mixed delays
Authors: Wen S.P. , Zeng Z.G. , Huang T.W. , Li C.J. 
Published: November 2013

SummaryThis paper is concerned with the problem of passivity analysis and passification for a class of stochastic impulsive memristor‐based piecewise linear (PWL) systems with mixed delays and nonlinearity disturbances. Based on the PWL memristor, a PWL system is set up. And some novel sufficient conditions are derived to ensure the passivity/passification performance, such that, for all admissible stochastic disturbances and nonlinearity, the closed‐loop stochastic impulsive memristor‐based PWL system is passive in the sense of expectation. Copyright © 2013 John Wiley & Sons, Ltd.
The Neglected “R” in a Time of Common Core
Authors: Mo Ya , Kopke Rachel A. , Hawkins Lisa K. , Troia Gary A. , Olinghouse Natalie G. 
Published: November 2013

AbstractDespite the need for writing competence in and out of school, writing has been deemed the neglected “R” in educational practice. Moreover, many students do not meet expected standards of writing performance. The Common Core State Standards (CCSS), adopted by 45 states, provides an opportunity to change the state of writing instruction on a national scale. This study evaluated the content coverage of theCCSSfor writing and language (CCSS‐WL). Results indicated thatCCSS‐WLcover some aspects of writing well, but others deemed important in research not well or not at all. Evidenced‐based practices for improving student writing performance to supplement theCCSS‐WLare provided. It is hoped that the appropriate curricular and instructional changes targeted toward the content of theCCSS‐WLand effective evidence‐based instructional practices can elevate writing from the neglected “R” in this time of Common Core.
Impact of Free Fatty Acids and Phospholipids on Reverse Micelles Formation and Lipid Oxidation in Bulk Oil
Authors: Kittipongpittaya Ketinun , Panya Atikorn , McClements David Julian , Decker Eric A. 
Published: November 2013

AbstractAssociation colloids such as phospholipid reverse micelles could increase the rate of lipid oxidation in bulk oils. In addition to phospholipids, other surface active minor components in commercial oils such as free fatty acids may impact lipid oxidation rates and the physical properties of reverse micelles. In this study, the effects of free fatty acids on changes in the critical micelle concentration (CMC) of 1,2‐Dioleoyl‐sn‐glycero‐3‐phosphocholine (DOPC) in stripped corn oil (SCO) were determined by using the 7,7,8,8‐tetracyanoquinodimethane solubilization technique. Different free fatty acids including myristoleic, oleic, elaidic, linoleic and eicosenoic were added at 0.5 % by wt along with the DOPC into the bulk oils. There was no significant effect of free fatty acids with different chain length, configuration and number of double bonds on the CMC value for DOPC in bulk oil. However, increasing concentrations of oleic acid (0.5 to 5 % by wt) caused the CMC value for DOPC in bulk oils to increase from 400 to 1,000 μmol/kg oil. Physical properties of DOPC reverse micelles in the presence of free fatty acids in bulk oils were also investigated by the small angle X‐ray scattering technique. Results showed that free fatty acids could impact on the reverse micelle structure of DOPC in bulk oils. Moreover, free fatty acid decreased pH inside reverse micelle as confirmed by the NMR studies. The oxidation studies done by monitoring the lipid hydroperoxide and hexanal formation revealed that free fatty acids exhibited pro‐oxidative activity in the presence and absence of DOPC. Different types of free fatty acids had similar pro‐oxidative activity in bulk oil.
Role‐modeling and conversations about giving in the socialization of adolescent charitable giving and volunteering
Authors: Ottoni‐Wilhelm Mark , Estell David B. , Perdue Neil H. 
Published: November 2013

ABSTRACTThis study investigated the relationship between the monetary giving and volunteering behavior of adolescents and the role‐modeling and conversations about giving provided by their parents. The participants are a large nationally‐representative sample of 12–18 year‐olds from thePanel Study of Income Dynamics'Child Development Supplement(n = 1244). Adolescents reported whether they gave money and whether they volunteered. In a separate interview parents reported whether they talked to their adolescent about giving. In a third interview, parents reported whether they gave money and volunteered. The results show that both role‐modeling and conversations about giving are strongly related to adolescents' giving and volunteering. Knowing that both role‐modeling and conversation are strongly related to adolescents' giving and volunteering suggests an often over‐looked way for practitioners and policy‐makers to nurture giving and volunteering among adults: start earlier, during adolescence, by guiding parents in their role‐modeling of, and conversations about, charitable giving and volunteering.
Brief report: Associations between adolescent girls' social–emotional intelligence and violence perpetration
Authors: Gower Amy L. , Shlafer Rebecca J. , Polan Julie , McRee Annie‐Laurie , McMorris Barbara J. , Pettingell Sandra L. , Sieving Renee E. 
Published: November 2013

ABSTRACTThis study examined associations between social–emotional intelligence (SEI) and two measures of violence perpetration (relational aggression and physical violence) in a cross‐sectional sample of high‐risk adolescent girls (N = 253). We evaluated three aspects of SEI: stress management, intrapersonal, and interpersonal skills. Results of a multiple linear regression model accounting for participants' age, race/ethnicity, and experiences of relational aggression victimization indicated that girls with better stress management skills were less likely to perpetrate relational aggression. A parallel model for perpetration of physical violence showed a similar pattern of results. Study findings suggest that SEI, and stress management skills in particular, may protect adolescent girls – including those who have been victims of violence – from perpetrating relational aggression and physical violence. Interventions that build adolescent girls' social and emotional skills may be an effective strategy for reducing their perpetration of violence.
The East European Platform in the late Ediacaran: new paleomagnetic and geochronological data
Authors: Fedorova N.M. , Levashova N.M. , Bazhenov M.L. , Meert J.G. , Sergeeva N.D. , Golovanova I.V. , Danukalov K.N. , Kuznetsov N.B. , Kadyrov A.F. , Khidiyatov M.M. 
Published: November 2013

Abstract
The paleogeography of the Earth, including the East European Platform, is very inaccurately defined for the interval 500–700 Ma. The quantity and quality of Late Precambrian–Cambrian paleomagnetic data on this platform are absolutely insufficient for reliable paleogeographical or paleotectonic reconstructions. Since there are almost no unstudied objects in the platform that could be used for paleomagnetic studies, it seems reasonable to consider the deformed platform margins. Of particular interest is the Bashkir anticlinorium (South Urals) with numerous Ediacaran sedimentary sections, some of which contain tuff beds suitable for isotope dating. We present paleomagnetic and geochronological data on the Upper Ediacaran Zigan Formation, sampled in the western part of the western limb of the Bashkir anticlinorium. The East European Platform must have been at near-equatorial latitudes at ∼550 Ma.
Time patterns of magmatic ore systems in circum-Pacific volcanoplutonic belts
Authors: Sharapov V.N. , Lapukhov A.S. , Smolyaninova L.G. 
Published: November 2013

AbstractIntegrate statistical processing of more than 1000 isotope dates tracing the history of circum-Pacific magmatic ore systems and related mineral deposits in volcanoplutonic belts allows the following inferences: (1) magmatic ore systems (MOS) of volcanic arcs generate monoand polycyclic volcanoplutonic deposits (VPD) with notably different formation times (longevities); (2) the MOS chronology bears periodicity of events in the post-Paleozoic history of the Pacific continental margin; (3) the time series of magmatic ore systems from different circum-Pacific segments show quasi-periodic patterns but the respective metallogenic epochs within the same time intervals have different phases and amplitudes, especially over the past 30 Myr; (4) each mineral type of VPD has its own periodicity; (5) the periodicity in formation times of mono- and polycyclic VPD differs from that in the times of their origin.
Geologic nature of regional magnetic and gravity anomalies in the Mongol-Transbaikalian province of the Central Asian Fold Belt
Authors: Vitte L.V. , Vasilevskiy A.N. 
Published: November 2013

Abstract
Regional gravity and magnetic anomalies are interpreted with regard to new geodynamic, geological, and tectonic schemes. Integrated analysis of these data confirms the deep origin of the processes which have created the largest igneous areas and zones of the eastern Central Asian Fold Belt.
Processing high-frequency electromagnetic logs from conducting formations: linearized 2D forward and inverse solutions with regard to eddy currents
Authors: Glinskikh V.N. , Nikitenko M.N. , Epov M.I. 
Published: November 2013

Abstract
High-performance algorithms and software have been designed for fast 2D forward modeling and inversion of high-frequency electromagnetic logs to recover the patterns of electrical conductivity and relative permittivity (dielectric constant) of rocks. Forward modeling implies linear representation, with regard to eddy current, of attenuations and phase shifts of electromagnetic fields propagating in 2D conducting formations. In order to improve the modeling quality, the background model is chosen proceeding from the eddy current pattern in a heterogeneous subsurface. The inverse solution is obtained by pseudoinversion of the sensitivity matrix of relative amplitudes and phases. Joint 2D inversion of phase shifts and attenuations improves the reliability of the inferred spatial conductivity distribution and allows estimating permittivity. The reported numerical experiments on inversion of synthetic and field EM logs prove the possibility of estimating the permittivity of complex terrigenous and carbonate reservoirs with water- and oil-filled porosity.
Electrochemistry of calcium precipitating bacteria in orthodontic wire
Authors: Dhandapani P. , MuraliKannan M. , Anandkumar B. , Maruthamuthu S. , Manoharan S.P. 
Published: November 2013

AbstractBackground: Calculus composed of inorganic and organic components with bacteria formed on teeth gets deposited on orthodontic wires. The reason for calculus formation and impact of calcium precipitating bacteria (CPB) on orthodontic wire were studied. A pilot study on electrochemical characterization of CPB on orthodontic wires was done.Methods: CPB were isolated from orthodontic patients and identified by molecular techniques. The electrochemical behavior of two isolates (CPB‐1 and CPB‐3) on orthodontic wires was studied by employing polarization and impedance techniques. The CPB morphology by scanning electron microscopy and chemical characterization of CPB and tooth pulp stone were studied by Fourier transform infrared (FTIR) and X‐ray diffraction (XRD).Results: The two isolates Bacillus megaterium (CPB‐1) and Paenibacillus sp. (CPB‐3) identified with 16S rRNA sequencing method increased pH of B4 medium from 5.32 to 8.3. The carboxylic acid and phosphate groups identified in FTIR analysis acted as nucleation sites for calcium deposition. The biogenic crystal phases identified in teeth pulp stone by XRD were similar to bacterial isolates cultured in the laboratory. The electrochemical studies with two CPB species revealed that biogenic calcium phosphate species act as cathodic inhibitors on orthodontic wire.Conclusion: The present study concluded that teeth pulp stone formation is due to CPB and high pH determines the mineralization process. Diffusion process and dispersive capacitive behavior indicate that the chloride ions may penetrate through calcium deposits and initiate pitting corrosion on orthodontic wire which may enhance the leaching of toxic elements in saliva.
Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis
Authors: Kishi T. , Meltzer H. Y. , Matsuda Y. , Iwata N. 
Published: November 2013

BackgroundA meta-analysis of the serotonin1A (5-HT1A) receptor partial agonist of the azapirone class as an anxiolytic drug for the treatment of major depressive disorder (MDD) has not previously been reported.MethodWe carried out a systematic review of the literature available in PubMed, the Cochrane Library database and PsycINFO up to 12 October 2013, and conducted a meta-analysis of randomized controlled trials (RCTs) comparing 5-HT1A agonists with placebo and RCTs of 5-HT1A agonist augmentation therapies for MDD treatment. We calculated the risk ratio (RR), number needed to treat (NNT)/number needed to harm (NNH) and 95% confidence intervals (CIs).ResultsFifteen RCTs comparing 5-HT1A agonists with placebo (total n = 2469, four studies with buspirone, seven with gepirone, three with ipsapirone and one with zalospirone) were identified. Pooled 5-HT1A agonists had significantly more responders (RR 0.74, 95% CI 0.65–083, p < 0.00001, NNT = 6, 12 trials, n = 1816) than placebo. Pooled 5-HT1A agonists were superior to placebo in discontinuation due to inefficacy (RR 0.49, p = 0.02, NNH = 16, p = 0.03, 10 trials, n = 1494) but were inferior to placebo in discontinuation due to side-effects (RR 1.88, p < 0.0001, NNH = 17, p = 0.001, 13 trials, n = 2196). However, all-cause discontinuation was similar in both groups (RR 0.99, p = 0.85, 14 trials, n = 2402). Four 5-HT1A agonist augmentation studies were identified (total n = 365, three buspirone studies and one tandospirone study). There were no statistically significant effects of 5-HT1A agonist augmentation therapies on response rate (RR 0.98, p = 0.85, four trials, n = 341). 5-HT1A agonist-related side-effects including gastrointestinal symptoms, dizziness, insomnia, palpitation, paresthesia and sweating were greater than with placebo (p < 0.00001 to p = 0.03).ConclusionsOur results suggest that 5-HT1A agonist has a more beneficial effect on MDD than placebo, but has several side-effects.
Some Renaissance, Baroque, and contemporary cultural elaborations of the art of memory
Authors: Bimler David L. 
Published: November 2013

AbstractThe target article addresses historical and present-day mnemotechnics as a practice. It also deserves scrutiny as culture writ small. For would-be Hermetic adepts of the Renaissance and Baroque, the ancient art of memory (AAOM) provided both an iconography and a projective-test vision of possibilities. In contemporary fiction, Memory Palaces become a metaphor for the workings of mind, of culture, and of information technology.
Forecasting Medical Work at Mass-Gathering Events: Predictive Model Versus Retrospective Review
Authors: Zeitz Kathryn M. , Zeitz Chris J. , Arbon Paul 
Published: November 2013

AbstractIntroduction:Mass-gathering events are dynamic and challenge traditional medical management systems. To improve the system for the provision of first aid at mass-gathering events, an evaluation of two models that assist in forecasting the number of patients presenting for first-aid services was conducted.Method:A prospective evaluation of a recurrent, mass-gathering event was undertaken comparing predicted patient presentations and ambulance transfers generated by a predictive model developed by Arbon et al and a retrospective review of seven years of historical, event data as described by Zeitz et al.Results:Patient presentation rate (per 1,000 patrons) for this event was 1.6 and the transport to hospital rate (per 1,000 patrons) was 0.07. The retrospective review closely predicted the actual overall attendance.Both methods forecast the number of patients presenting on a daily basis. The prediction proved to be more accurate, on a day-by-day basis, using the Zeitz method.Conclusion:The Arbon method is particularly useful for events where there is no or limited information about previous medical work. Retrospective review of data generated from specific events (Zeitz method) considers the unique and individual variability that can occur from event to event and is more accurate at predicting patient presentations when the data are available. Both methods have the potential to be used more frequently to adequately and efficiently plan for the resources required for specific events.
Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1
Authors: Rutherford C , Childs S , Ohotski J , McGlynn L , Riddick M , MacFarlane S , Tasker D , Pyne S , Pyne N J , Edwards J , Palmer T M 
Published: November 2013

AbstractAlthough the ability of bioactive lipid sphingosine-1-phosphate (S1P) to positively regulate anti-apoptotic/pro-survival responses by binding to S1P1 is well known, the molecular mechanisms remain unclear. Here we demonstrate that expression of S1P1 renders CCL39 lung fibroblasts resistant to apoptosis following growth factor withdrawal. Resistance to apoptosis was associated with attenuated accumulation of pro-apoptotic BH3-only protein Bim. However, although blockade of extracellular signal-regulated kinase (ERK) activation could reverse S1P1-mediated suppression of Bim accumulation, inhibition of caspase-3 cleavage was unaffected. Instead S1P1-mediated inhibition of caspase-3 cleavage was reversed by inhibition of phosphatidylinositol-3-kinase (PI3K) and protein kinase C (PKC), which had no effect on S1P1 regulation of Bim. However, S1P1 suppression of caspase-3 was associated with increased expression of anti-apoptotic protein Mcl-1, the expression of which was also reduced by inhibition of PI3K and PKC. A role for the induction of Mcl-1 in regulating endogenous S1P receptor-dependent pro-survival responses in human umbilical vein endothelial cells was confirmed using S1P receptor agonist FTY720-phosphate (FTY720P). FTY720P induced a transient accumulation of Mcl-1 that was associated with a delayed onset of caspase-3 cleavage following growth factor withdrawal, whereas Mcl-1 knockdown was sufficient to enhance caspase-3 cleavage even in the presence of FTY720P. Consistent with a pro-survival role of S1P1 in disease, analysis of tissue microarrays from ER+ breast cancer patients revealed a significant correlation between S1P1 expression and tumour cell survival. In these tumours, S1P1 expression and cancer cell survival were correlated with increased activation of ERK, but not the PI3K/PKB pathway. In summary, pro-survival/anti-apoptotic signalling from S1P1 is intimately linked to its ability to promote the accumulation of pro-survival protein Mcl-1 and downregulation of pro-apoptotic BH3-only protein Bim via distinct signalling pathways. However, the functional importance of each pathway is dependent on the specific cellular context.