bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutting Edge: An Inactive Chromatin Configuration at the IL-10 Locus in Human Neutrophils
Authors: Tamassia Nicola , Zimmermann Maili , Castellucci Monica , Ostuni Renato , Bruderek Kirsten , Schilling Bastian , Brandau Sven , Bazzoni Flavia , Natoli Gioacchino , Cassatella Marco A. 
Published: January 2013

Abstract
To identify the molecular basis of IL-10 expression in human phagocytes, we evaluated the chromatin modification status at their IL-10 genomic locus. We analyzed posttranslational modifications of histones associated with genes that are active, repressed, or poised for transcriptional activation, including H3K4me3, H4Ac, H3K27Ac, and H3K4me1 marks. Differently from autologous IL-10–producing monocytes, none of the marks under evaluation was detected at the IL-10 locus of resting or activated neutrophils from healthy subjects or melanoma patients. By contrast, increased H3K4me3, H4Ac, H3K4me1, and H3K27Ac levels were detected at syntenic regions of the IL-10 locus in mouse neutrophils. Altogether, data demonstrate that human neutrophils, differently from either monocytes or mouse neutrophils, cannot switch on the IL-10 gene because its locus is in an inactive state, likely reflecting a neutrophil-specific developmental outcome. Implicitly, data also definitively settle a currently unsolved issue on the capacity of human neutrophils to produce IL-10.
CD8α+ Dendritic CellTransPresentation of IL-15 to Naive CD8+ T Cells Produces Antigen-Inexperienced T Cells in the Periphery with Memory Phenotype and Function
Authors: Sosinowski Tomasz , White Jason T. , Cross Eric W. , Haluszczak Catherine , Marrack Philippa , Gapin Laurent , Kedl Ross M. 
Published: January 2013

AbstractVarious populations of memory phenotype CD8+ T cells have been described over the last 15–20 y, all of which possess elevated effector functions relative to naive phenotype cells. Using a technique for isolating Ag-specific cells from unprimed hosts, we recently identified a new subset of cells, specific for nominal Ag, but phenotypically and functionally similar to memory cells arising as a result of homeostatic proliferation. We show in this study that these virtual memory (VM) cells are independent of previously identified innate memory cells, arising as a result of their response to IL-15 trans presentation by lymphoid tissue-resident CD8α+ dendritic cells in the periphery. The absence of IL-15, CD8+ T cell expression of either CD122 or eomesodermin or of CD8a+ dendritic cells all lead to the loss of VM cells in the host. Our results show that CD8+ T cell homeostatic expansion is an active process within the nonlymphopenic environment, is mediated by IL-15, and produces Ag-inexperienced memory cells that retain the capacity to respond to nominal Ag with memory-like function. Preferential engagement of these VM T cells into a vaccine response could dramatically enhance the rate by which immune protection develops.
Robust Adaptive Terminal Sliding Mode Synchronized Control for a Class of Non‐Autonomous Chaotic Systems
Authors: Yang Chi‐Ching 
Published: January 2013

AbstractFor a general class of non‐autonomous chaotic systems, the purpose of this study is to introduce a robust adaptive terminal sliding mode controller for achieving synchronization between two of the same kind of systems in the presence of system uncertainties and external disturbances. The proposed controller, associated with adaptive feedback gains, can compensate nonlinear dynamics of the synchronous error system without active elimination. Meanwhile, these feedback gains are not to be determined in advance but updated by the adaptive rules without known bounds of system uncertainties and external disturbances. In the sense of the Lyapunov stability theorem, sufficient conditions to guarantee the stable synchronization are given. Numerical case studies are performed to verify the effectiveness of presented scheme.
Trust‐based workflow refactoring for concurrent scheduling in service‐oriented environment
Authors: Wang Mingzhong , Zhang Xuyun , Zhu Liehuang , Liao Lejian 
Published: January 2013

SUMMARYWorkflow scheduling has been extensively studied to improve the system performance. However, existing approaches are usually built on predefined workflow graph structure, neglecting the possibility that a workflow graph itself may be changeable when certain conditions are satisfied. Therefore, in this paper, we propose the concept of graph refactoring that transforms certain types of sequential tasks to run in parallel without changing system's functionality. We first provide a classification for task dependencies in workflows and identify that previously sequential task ordering in loose control dependency can be scheduled to run in parallel as long as supporting services are trustworthy. With this concept, we present a refactoring algorithm to traverse, restructure, and parallelize loose control dependencies in the graph when the reputations of related executing services are above certain threshold. In addition, refactoring effects on common sub‐graph structures are analyzed and discussed. In practice, our algorithm can be integrated into existing workflow management systems as a preprocessor to generate a new functionally equivalent working graph with more concurrent branches for further scheduling. Experiments and analysis show that graph refactoring can improve the system performance scalably because of concurrent execution of previously sequential tasks. Copyright © 2013 John Wiley & Sons, Ltd.
Connecting the dots: Mobilizing theory to reveal the big picture in social psychology (and why we should do this)
Authors: Ellemers Naomi 
Published: January 2013

AbstractDuring the past 20 years, practices in social psychology have drifted toward the publication of brief research reports as the main outlet for empirical findings, resulting in an exponential increase of the number of publications in our field. Recent developments questioning the reliability of these findings have increased the focus on (methodological) details and have prompted efforts to establish the robustness of isolated phenomena. Both types of developments carry the danger of impeding rather than promoting progress in the field. We can only build a cumulative knowledge base when we succeed in connecting these dots. Developing and examining broader theories about psychological processes and their implications can help connect different insights and elucidate their further implications in a way that can be used and understood within and beyond the boundaries of our discipline. Copyright © 2013 John Wiley & Sons, Ltd.
Seismic performance of highway bridges with fusing bearing components for quasi‐isolation
Authors: Filipov Evgueni T. , Revell Jessica R. , Fahnestock Larry A. , LaFave James M. , Hajjar Jerome F. , Foutch Douglas A. , Steelman Joshua S. 
Published: January 2013

SUMMARYModern highway bridges in Illinois are often installed with economical elastomeric bearings that allow for thermal movement of the superstructure, and steel fixed bearings and transverse retainers that prevent excessive movement from service‐level loadings. In the event of an earthquake, the bearing system has the potential to provide a quasi‐isolated response where failure of sacrificial elements and sliding of the bearings can cause a period elongation and reduce or cap the force demands on the substructure. A computational model that has been calibrated for the expected nonlinear behaviors is used to carry out a parametric study to evaluate quasi‐isolated bridge behavior. The study investigates different superstructure types, substructure types, substructure heights, foundation types, and elastomeric bearing types. Overall, only a few bridge variants were noted to unseat for design‐level seismic input in the New Madrid Seismic Zone, indicating that most structures in Illinois would not experience severe damage during their typical design life. However, Type II bearing systems, which consist of an elastomeric bearing and a flat PTFE slider, would in some cases result in critical damage from unseating at moderate and high seismic input. The sequence of damage for many bridge cases indicates yielding of piers at low‐level seismic input. This is caused by the high strength of the fixed bearing element, which justifies further calibration of the quasi‐isolation design approach. Finally, the type of ground motion, pier height, and bearing type were noted to have significant influence on the global bridge response. Copyright © 2013 John Wiley & Sons, Ltd.
Unintentional Role Models: Links Between Maternal Eating Psychopathology and the Modelling of Eating Behaviours
Authors: Palfreyman Zoe , Haycraft Emma , Meyer Caroline 
Published: January 2013

AbstractThis study explored the relationships between maternal modelling of eating behaviours with reported symptoms of maternal eating psychopathology, anxiety and depression. Mothers (N = 264) with a child aged 1.5 to 8 years completed three self‐report measures designed to assess modelling of eating behaviours, eating psychopathology and levels of anxiety and depression. The study found that higher levels of maternal eating psychopathology were positively associated with eating behaviours that were unintentionally modelled by mothers but that maternal eating psychopathology was not associated with more overt/intentional forms of parental modelling. In addition, higher levels of maternal depression were associated with lower levels of both unintentional and intentional forms of maternal modelling, whereas maternal anxiety was not found to correlate with modelling behaviours. This study highlights the possible detrimental influences of maternal mental health in relation to mothers providing their child with a positive parental role model around eating and feeding. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
WAITING TIMES AND SOCIOECONOMIC STATUS. EVIDENCE FROM NORWAY
Authors: Kaarboe Oddvar , Carlsen Fredrik 
Published: January 2013

ABSTRACTWe investigate whether socioeconomic status, measured by income and education, affects waiting time when controls for severity and hospital‐specific conditions are included. We also examine which aspects of the hospital supply (attachment to local hospital, traveling time, or choice of hospital) matter most for unequal treatment of different socioeconomic groups. The study uses administrative data from all elective inpatient and outpatient stays in somatic hospitals in Norway. The main results are that we find very little indication of discrimination with regard to income and education when both severity and aspects of hospital supply are controlled for. This result holds for both men and women. Copyright © 2013 John Wiley & Sons, Ltd.
Augmenting Outerplanar Graphs to Meet Diameter Requirements
Authors: Ishii Toshimasa 
Published: January 2013

AbstractGiven an undirected graph and an integer , we consider the problem of augmenting G by a minimum set of new edges so that the diameter becomes at most D. It is known that no constant factor approximation algorithms to this problem with an arbitrary graph G can be obtained unless , while the problem with only a few graph classes such as forests is approximable within a constant factor. In this article, we give the first constant factor approximation algorithm to the problem with an outerplanar graph G. We also show that if the target diameter D is even, then the case where G is a partial 2‐tree is also approximable within a constant.
Recent Transformations in China's Economic, Social, and Education Policies for Promoting Innovation and Creativity
Authors: Pang Weiguo , Plucker Jonathan A. 
Published: January 2013

AbstractThe purpose of this study is to review major Chinese policies related to creativity education. We first identify and describe the role of innovation and creativity in economic and social development policies over the past 20 years, then analyze how the call for enhanced Chinese innovation and creativity was actualized in corresponding education policies. The article concludes with an analysis of issues surrounding Chinese education policy toward creativity and several directions for future research in this area.
Stable Isotopic Evidence of Ancient Maya Diet at Caledonia, Cayo District, Belize
Authors: Rand A. J. , Healy P. F. , Awe J. J. 
Published: January 2013

AbstractThe skeletal remains of 18 individuals interred at the ancient Maya site of Caledonia (100 to 1000 C.E.), located in the Cayo District of Belize, w ere sampled for stable carbon and nitrogen isotope analysis in order to reconstruct their diet. Stable carbon and nitrogen isotope ratios in 18 bone collagen samples and stable carbon isotope ratios in bioapatite from 15 bone and 6 tooth enamel samples were assessed. Small sample sizes precluded the assessment of dietary variation with respect to age, sex, social status or time period among the Caledonia Maya. However, the sampled individuals consumed a varied diet consisting of maize, supplemented with some C3plants, terrestrial herbivores and/or lower order freshwater resources such as snails and molluscs and possibly maize‐fed animals. This dietary variability with an emphasis on maize is unsurprising given the biological diversity surrounding the site and the known importance of this crop to the ancient Maya. As expected, the isotopic values from Caledonia are similar to those from nearby sites from similar time periods. However, four individuals exhibit a marine dietary signature, possibly indicating inland trade of marine resources from coastal sites, or the migration of coastal people to Caledonia. This study demonstrates the validity of sampling small, fragmented collections from minor Maya centres in order to gain valuable insight into ancient Maya dietary practices. Copyright © 2013 John Wiley & Sons, Ltd.
Simulating Public Health Capacity to Measure Performance: E. coli O157 at the North Carolina State Fair
Authors: Winter Sharolyn A. , Ivy Julie S. , Horney Jennifer A. 
Published: January 2013

AbstractDespite the investment of billions of dollars in federal funding for emergency preparedness and response initiatives, broadly accepted performance measures for determining the efficacy of these systems have yet to be established. The inability to accurately capture this information hinders the ability to measure the true degree of preparedness. The North Carolina Public Health Information Network (NC PHIN), a key component of North Carolina's public health system, has promise as a means to measure emergency preparedness and response. In this paper, we look at how NC PHIN has increased emergency preparedness and response capacity by presenting a simulation of the 2004 State Fair Escherichia coli outbreak. We found that although the capacity exists within NC PHIN to increase emergency preparedness and response, some factors limit NC PHIN's effectiveness. Our findings suggest that proper resource allocation will be necessary in order to realize the potential of NC PHIN.
MODELLING CHANGES IN SALMON HABITAT ASSOCIATED WITH RIVER CHANNEL RESTORATION AND FLOW‐INDUCED CHANNEL ALTERATIONS
Authors: Gard M. 
Published: January 2013

ABSTRACTThe River2D two‐dimensional hydraulic and habitat model was used to simulate fall‐run Chinook salmon (Oncorhynchus tschawytscha) spawning and fry and juvenile rearing habitat of the first phase of a stream channel restoration project on Clear Creek, California. Habitat was simulated for a range of stream flows: (1) before restoration; (2) based on the restoration design; (3) immediately after restoration; and (4) after one and two large flow events. Hydraulic and structural data were collected for three sites before restoration, and prerestoration habitat was simulated. Habitat simulated for these sites was extrapolated to the prerestoration area based on habitat mapping. The topographical plan for the restoration was used to simulate the anticipated habitat after restoration. Although the restoration increased spawning habitat, it was less successful for rearing habitat. Channel changes associated with high‐flow events did not entirely negate the benefits of the restoration project. The results of this study point out the need for models that can simulate the changes in channel topography associated with high‐flow events, which could then be used to simulate habitat over time. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low-Rhodamine123-Retention Cell Compartment Enriched for Melanoma Stem Cell Activity
Authors: Touil Yasmine , Zuliani Thomas , Wolowczuk Isabelle , Kuranda Klaudia , Prochazkova Jirina , Andrieux Joris , Le Roy Helene , Mortier Laurent , Vandomme Jerome , Jouy Nathalie , Masselot Bernadette , Ségard Pascaline , Quesnel Bruno , Formstecher Pierre , Polakowska Renata 
Published: January 2013

Abstract
Melanoma is one of the most aggressive and extremely resistant to conventional therapies neoplasms. Recently, cellular resistance was linked to the cancer stem cell phenotype, still controversial and not well-defined. In this study, we used a Rhodamine 123 (Rh123) exclusion assay to functionally identify stem-like cells in metastatic human melanomas and melanoma cell lines. We demonstrate that a small subset of Rh123-low-retention (Rh123low) cells is enriched for stem cell-like activities, including the ability to self-renew and produce nonstem Rh123high progeny and to form melanospheres, recapitulating the phenotypic profile of the parental tumor. Rh123low cells are relatively quiescent and chemoresistant. At the molecular level, we show that melanoma Rh123low cells overexpress HIF1α, pluripotency factor OCT4, and the ABCB5 marker of melanoma stem cells and downregulate the expression of Cyclin D1 and CDK4. Interestingly, a short treatment with LY294002, an inhibitor of the PI3K/AKT pathway, specifically reverts a subset of Rh123high cells to the Rh123low phenotype, whereas treatment with inhibitors of mammalian target of rapamycin, phosphatase and tensin homolog or mitogen-activated protein kinase signaling does not. This phenotypic switching was associated with reduced levels of the HIF1α transcript and an increase in the level of phosphorylated nuclear FOXO3a preferentially in Rh123low cells. Moreover, the Rh123low cells became less quiescent and displayed a significant increase in their melanosphere-forming ability. All the above indicates that the Rh123low melanoma stem cell pool is composed of cycling and quiescent cells and that the PI3K/AKT signaling while maintaining the quiescence of Rh123low G0 cells promotes the exit of cycling cells from the stem cell compartment.
Understanding Sheng Nu (“Leftover Women”): the Phenomenon of Late Marriage among Chinese Professional Women
Authors: To Sandy 
Published: January 2013

AbstractIn the past few decades, there has been a rise in the number of single, unmarried Chinese professional women, which is known as the sheng nu or “leftover women” phenomenon. Through an interactionist grounded theory method, this study has located the interactional constraints faced by 50 single Chinese professional women that were issued by their male romantic partners and parents, respectively. “Discriminatory” and “controlling” gendered constraints issued by the women's male suitors and partners reflected the persistence of the Chinese patriarchal structure, and this was found to be the leading cause of the women being “leftover” in the marriage market. Parents' traditional views continued to exert strong influences on the women's marital choices, but this was seen to conflict with their more “modern” views toward advocating and supporting the women's strong economic achievements. The four different types of Chinese professional women that were constructed based on their different partner choice strategies not only gave rise to an in‐depth and nuanced understanding of the sheng nu phenomenon in China, but could also be generalized toward understanding the marital choices of single professional women in other patriarchal societies who faced similar dilemmas in reconciling interactional constraints imposed by men and parents alike.
Statistical Model of Shape Moments with Active Contour Evolution for Shape Detection and Segmentation
Authors: Zhang Yan , Matuszewski Bogdan J. , Histace Aymeric , Precioso Frédéric 
Published: January 2013

Abstract
This paper describes a novel method for shape representation and robust image segmentation. The proposed method combines two well known methodologies, namely, statistical shape models and active contours implemented in level set framework. The shape detection is achieved by maximizing a posterior function that consists of a prior shape probability model and image likelihood function conditioned on shapes. The statistical shape model is built as a result of a learning process based on nonparametric probability estimation in a PCA reduced feature space formed by the Legendre moments of training silhouette images. A greedy strategy is applied to optimize the proposed cost function by iteratively evolving an implicit active contour in the image space and subsequent constrained optimization of the evolved shape in the reduced shape feature space. Experimental results presented in the paper demonstrate that the proposed method, contrary to many other active contour segmentation methods, is highly resilient to severe random and structural noise that could be present in the data.
Non‐syndromic Sensorineural Prelingual Deafness: The Importance of Genetic Counseling in Demystifying Parents’ Beliefs About the Cause of Their Children's Deafness
Authors: Rodrigues Fidjy , Paneque Milena , Reis Cláudia , Venâncio Margarida , Sequeiros Jorge , Saraiva Jorge 
Published: January 2013

AbstractRecent advances in molecular genetics have allowed the determination of the genetic cause of some childhood non‐syndromic deafness. In Portugal only a small proportion of families are referred to a clinical genetics service in order to clarify the etiology of the deafness and to provide genetic counseling. Consequently, there are no published studies of the prior beliefs of parents about the causes of hereditary deafness of their children and their genetic knowledge after receipt of genetic counseling. In order to evaluate the impact of genetic counseling, 44 parents of 24 children with the diagnosis of non‐syndromic sensorineural prelingual deafness due to mutations in theGJB2(connexin 26), completed surveys before and after genetic counseling. Before counseling 13.6 % of the parents knew the cause of deafness; at a post‐counseling setting this percentage was significantly higher, with 84.1 % of the parents accurately identifying the etiology. No significant differences were found between the answers of mothers and fathers either before or after genetic counseling. Parents’ level of education was a significant factor in pre‐test knowledge. After genetic counseling 95.5 % of the parents stated that the consultation had met their expectations, 70.5 % remembered correctly the inheritance pattern, and 93.2 % correctly recalled the chance of risk of deafness. These results underline the importance of genetic counseling in demystifying parents’ beliefs about the etiology of their children's deafness.