bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of circadian clock disruption on type 2 diabetes
Authors: Tran Hong Thuan , Kondo Takeru , Ashry Amal , Fu Yunyu , Okawa Hiroko , Sawangmake Chenphop , Egusa Hiroshi 
Published: August 2024

IntroductionType 2 diabetes (T2D) is the predominant form of diabetes mellitus and is among the leading causes of death with an increasing prevalence worldwide. However, the pathological mechanism underlying T2D remains complex and unclear. An increasing number of studies have suggested an association between circadian clock disruption and high T2D prevalence.MethodThis review explores the physiological and genetic evidence underlying T2D symptoms associated with circadian clock disturbances, including insulin secretion and glucose metabolism.Results and DiscussionNotably, circadian clock disruption reduces insulin secretion and insulin sensitivity and negatively affects glucose homeostasis. The circadian clock regulates the hypothalamic–pituitary–adrenal axis, an important factor that regulates glucose metabolism and influences T2D progression. Therefore, circadian clock regulation is an attractive, novel therapeutic approach for T2D, and various circadian clock stabilizers play therapeutic roles in T2D. Lastly, this review suggests novel therapeutic and preventive approaches using circadian clock regulators for T2D.
Biological features and quality comprehensive analysis of twelve germplasm resources of the genus Allium from Tibet
Authors: Wang Huaifeng , Yang Haixing , Yu Xuena , Xie Yongdong , Bai Yu , Dai Qiya , Liang Le , Tang Wen , Yong Mao , Wang Luzhou , Huang Zhi , Sun Bo , Li Huanxiu , Tang Yi 
Published: August 2024

IntroductionAllium is important vegetables and seasonings in China, Tibet is rich in unique resources of the genus Allium, but lacks development and utilization.MethodsWe compared the biological features and comprehensively evaluating the quality of twelve germplasm resources of the genus Allium collected from Tibet.ResultsThe results revealed that nine germplasm resources were bolting and bloom normally except for SC015, SC019, and SC048, all twelve germplasm resources were able to vegetative growth. The individual differences in moisture, soluble sugar, and protein content among the twelve germplasm resources were relatively small, with pyruvic acid content ranging from 0.11 to 1.12 mg/g and a large variation coefficient. A total of 8 categories and 97 volatile compounds were detected in twelve germplasm resources, the majority possessed the highest proportions of aldehydes and organosulfur compounds, but there were certain differences between the different Allium species. Additionally, 11 to 16 types of free amino acids were present in all germplasm resources, proline exhibited the highest content. The total content of essential and non-essential amino acids in SC009 was the highest. Carbon (C) accounted for the largest proportion of all elements, and the contents of other mineral elements varied greatly among the different plants.ConclusionIn conclusion, combined with biological performance and comprehensive evaluation of quality, SC009 is the excellent germplasm resource suitable for growth and capable of reproduction with good quality. These results improved the exploitation and utilization of the genus Allium in Tibet, as well as provided germplasm resources for high-quality breeding of the genus Allium.
A lightweight dual-attention network for tomato leaf disease identification
Authors: Zhang Enxu , Zhang Ning , Li Fei , Lv Cheng 
Published: August 2024

Tomato disease image recognition plays a crucial role in agricultural production. Today, while machine vision methods based on deep learning have achieved some success in disease recognition, they still face several challenges. These include issues such as imbalanced datasets, unclear disease features, small inter-class differences, and large intra-class variations. To address these challenges, this paper proposes a method for classifying and recognizing tomato leaf diseases based on machine vision. First, to enhance the disease feature details in images, a piecewise linear transformation method is used for image enhancement, and oversampling is employed to expand the dataset, compensating for the imbalanced dataset. Next, this paper introduces a convolutional block with a dual attention mechanism called DAC Block, which is used to construct a lightweight model named LDAMNet. The DAC Block innovatively uses Hybrid Channel Attention (HCA) and Coordinate Attention (CSA) to process channel information and spatial information of input images respectively, enhancing the model’s feature extraction capabilities. Additionally, this paper proposes a Robust Cross-Entropy (RCE) loss function that is robust to noisy labels, aimed at reducing the impact of noisy labels on the LDAMNet model during training. Experimental results show that this method achieves an average recognition accuracy of 98.71% on the tomato disease dataset, effectively retaining disease information in images and capturing disease areas. Furthermore, the method also demonstrates strong recognition capabilities on rice crop disease datasets, indicating good generalization performance and the ability to function effectively in disease recognition across different crops. The research findings of this paper provide new ideas and methods for the field of crop disease recognition. However, future research needs to further optimize the model’s structure and computational efficiency, and validate its application effects in more practical scenarios.
Dynamic patterns of gene expressional and regulatory variations in cotton heterosis
Authors: Huang Chujun , Cheng Yu , Hu Yan , Fang Lei , Si Zhanfeng , Chen Jinwen , Cao Yiwen , Guan Xueying , Zhang Tianzhen 
Published: August 2024

PurposeAlthough the application of heterosis has significantly increased crop yield over the past century, the mechanisms underlying this phenomenon still remain obscure. Here, we applied transcriptome sequencing to unravel the impacts of parental expression differences and transcriptomic reprogramming in cotton heterosis.MethodsA high-quality transcriptomic atlas covering 15 developmental stages and tissues was constructed for XZM2, an elite hybrid of upland cotton (Gossypium hirsutum L.), and its parental lines, CRI12 and J8891. This atlas allowed us to identify gene expression differences between the parents and to characterize the transcriptomic reprogramming that occurs in the hybrid.ResultsOur analysis revealed abundant gene expression differences between the parents, with pronounced tissue specificity; a total of 1,112 genes exhibited single-parent expression in at least one tissue. It also illuminated transcriptomic reprogramming in the hybrid XZM2, which included both additive and non-additive expression patterns. Coexpression networks between parents and hybrid constructed via weighted gene coexpression network analysis identified modules closely associated with fiber development. In particular, key regulatory hub genes involved in fiber development showed high-parent dominant or over dominant patterns in the hybrid, potentially driving the emergence of heterosis. Finally, high-depth resequencing data was generated and allele-specific expression patterns examined in the hybrid, enabling the dissection of cis- and trans-regulation contributions to the observed expression differences.ConclusionParental transcriptional differences and transcriptomic reprogramming in the hybrid, especially the non-additive upregulation of key genes, play an important role in shaping heterosis. Collectively, these findings provide new insights into the molecular basis of heterosis in cotton.
Examining the link between coach-athlete relationship and athlete burnout among college soccer players: the mediating role of training satisfaction
Authors: Jiahao Liu , Jing Li 
Published: August 2024

PurposeAthlete burnout is an adverse factor that usually decreases athletes' sports performance and reduces their passion for athletic career development. The present study examined the association of coach-athlete relationship, training satisfaction, and athlete burnout, and then explored the training satisfaction as a mediating role of the effect of coach-athlete relationship on athlete burnout among college soccer players.MethodsSoccer players from seven Chinese higher education institutions were recruited for the study. The participants were selected using stratified random sampling and included 218 participants. The Coach-Athlete Relationship Scale, Training Satisfaction Scale, and Athlete Burnout Questionnaire were used to collect data from the participants. Pearson's product-moment correlation analysis, linear regression analysis, and bootstrap method were conducted to analyze the collected data set.ResultsThe results showed that (1) there was a significant correlation between coach-athlete relationship, training satisfaction, and athlete burnout. (2) coach-athlete relationship and training satisfaction significantly negatively predicted athlete burnout (β = −0.39, p &lt; 0.001; β = - 0.29, p &lt; 0.001). (3) training satisfaction had a significantly mediating effect on the relationship between coach-athlete relationship and athlete burnout (β = −0.15, p &lt; 0.001, ES = 0.28).ConclusionCoach-athlete relationship can not only directly negative impact athlete burnout but can also negatively influence athlete burnout through the mediating effect of training satisfaction. Therefore, we suggest the following to alleviate athlete burnout: on one hand, coaches can provide more communication opportunities for athletes to improve the coach-athlete relationship. On the other hand, teams can enhance training satisfaction by building team culture.
Prison healthcare service use and associated factors: a cross sectional study in Northwestern Ethiopia
Authors: Yesuf Yassin Mohammed , Birhan Amlaku Alemu , Birara Addisu Gedlu , Adimas Bewket Dereje , Bezabh Abebe Bahiru , Agmase Nega Gedefaw 
Published: August 2024

IntroductionStudies on inmates’ Health Care Service (HCS) utilization are scarce globally, infrequent in Ethiopia while findings about the factors associated with HCS utilization are inconsistent. The present study, therefore, examined inmates’ HCS utilization and associated socio-demographic and imprisonment related factors in Northwestern Ethiopia.MethodsThe study employed institution-based cross sectional research design and data was collected using questionnaire from 422 inmates in three prisons. The questionnaire collected data about prisoners’ demographic characters, imprisonment related information and HCS utilization. Descriptive statistical techniques as well as bi-variate and multiple logistic regressions were used to analyse the data.Results and discussionsThe study found that 72.5%, 66.1% and 13.3% of the inmates, respectively, used medical services, guidance and counseling services, and psychiatric services. Inmates with primary education, with secondary education, and who know the availability of the services were more likely to use medical services. Inmates with accused status were less likely to use medical services than inmates with convict status. Divorced marital status and knowledge of the service availability were associated with high guidance and counseling service use. An increase in the length of stay in the prison was associated with a decrease in psychiatry service use while knowledge of service availability was associated with higher odds of psychiatry service use. There are high medical care service utilization while low mental health care service utilization among inmates in Northwestern Ethiopia. Results of the study implied that there is a critical need for immediate health care service promotion and education measures. Besides, there are also needs for large scale, longitudinal and potentially cross-cultural studies to better understand additional factors that influence inmates’ HCS utilization.
Severity of inattention symptoms, experiences of being bullied, and school anxiety as mediators in the association between excessive short-form video viewing and school refusal behaviors in adolescents
Authors: Du Yuru , Wang Jianqiang , Wang Ziyan , Liu Jiuying , Li Shaoxiong , Lv Jing , Peng Yuhan , Chang Shining , Li Miaomiao , Liu Huan , Liu Xuan , Yu Xuezhu , Li Youdong 
Published: August 2024

BackgroundRecent years have seen an increase in school refusal behavior among adolescents, potentially due to factors like excessive short-form video viewing, bullying, and school anxiety. Limited research has investigated how these factors contribute to school refusal behavior. This study used random forest regression, path analysis, and network analysis to identify key variables and pathways leading to school refusal behavior.MethodsIn this cross-sectional questionnaire-based study, 2,056 (996 male, 1,060 female, mean age: 14.79 ± 1.24 years) middle and senior high school students were asked to complete the School Refusal Behavior Assessment questionnaire to assess school refusal behavior features, the Excessive Short-Form Video Viewing Scale as well as self-reported viewing times during leisure days to assess excessive short-form video viewing, the SNAP-IV Rating Scale to assess the severity of inattention symptoms, and the self-administered questionnaires to assess experiences of being bullied and school anxiety.ResultsThe prevalence of school refusal behavior in the surveyed adolescents was found to be 31.9% [95% confidence interval (CI): 29.8–33.9%]. In terms of significance, the severity of inattention symptoms exhibited the greatest predictive power, while excessive short-form video viewing accounted for the most variance. Path analysis revealed that excessive short-form video viewing not only directly affects school refusal behavior features but also does so indirectly through severity of inattention symptoms and school anxiety. Key bridge factors in this pathway include intense fear and anxiety associated with school attendance, manifesting as somatic symptoms and avoidance behaviors.ConclusionThe findings indicate that not only does excessive short-form video viewing directly influence school refusal behavior features in adolescents, but it also indirectly impacts these features through mechanisms involving severity of inattention symptoms and school anxiety. The bridge factors highlight potential targets for interventions among the SRB features and predictors.
Histopathologic predictors of recurrence and survival in early T stage oral tongue squamous cell carcinoma
Authors: Damazo Benjamin J. , Punjabi Nihal A. , Liu Yuan F. , Inman Jared C. 
Published: August 2024

ObjectivesRecurrence and survival in early T-stage oral tongue squamous cell carcinoma (OTSCC) may be impacted by histopathologic risk factors. This study aims to examine which of these factors predict long-term outcomes of T1 and T2 OTSCC.MethodsA retrospective review of T1 and T2 OTSCC patients treated with surgery at a single tertiary care center was conducted. Multivariate regression and Kaplan-Meier survival plots were used to identify predictors of recurrence and compare disease-free survival respectively.Results100 consecutive patients were studied. Of these, 51 were staged pT1, 49 pT2, 69 pN0, 10 pN1, and 21 pN2. Multivariate regression analysis revealed that &gt;4 nodes was the strongest predictor of overall recurrence [odds ratio 1.68 (1.23–2.28), p = 0.001], while &gt;4 nodes [odds ratio 1.14 (1.09–1.85), p = 0.008] and pT2 [odds ratio 1.15 (1.01–1.30), p = 0.033] were predictors of local recurrence (R2 = 0.112). Five-year disease-free survival was not significantly impacted by any risk factors except for the number of positive nodes—86% for ≤4 nodes vs. 20% for &gt;4 nodes (p &lt; 0.001)—and pathologic T-stage—90% for pT1 vs. 75% for pT2 (p = 0.035) regardless of adjuvant radiation and/or chemotherapy use.ConclusionsPatients who underwent adjuvant radiation and/or chemotherapy had similar survival to those who did not despite having worse overall tumor prognostic factors. Adding adjuvant therapy may equalize some high-risk histopathologic factors. In the highest risk patients—specifically those with pathologic &gt;4 nodes and pT2 staging—adjuvant therapy should be considered.
Understanding inequalities in the coverage of adolescent sexual and reproductive health services: a qualitative case study of the selected regions of Zambia
Authors: Munakampe Margarate Nzala , Ngoma-Hazemba Alice , Sampa Mutale , Jacobs Choolwe N. 
Published: August 2024

IntroductionDespite substantial investment in improving healthcare among adolescents in low- and middle-income countries, barriers to access and utilization of services persist, especially to sexual and reproductive health (SRH) services. In response to adolescents' health service needs due to their vulnerability, interventions aimed at improving access and utilization of sexual and reproductive health services have been implemented in specific regions of Zambia. To highlight progress in the access and the overall delivery of services in Zambia, in the wake of a system-level funding mechanism, this paper aims to understand the accessibility, availability, acceptability and quality (AAAQ) of health services provided to young people.Materials and methodsIn a qualitative case study, 48 discussions- 32 individual interviews with stakeholders and 16 focus group discussions, consisting of 128 male and female adolescents were conducted in six districts from Eastern, Southern and Muchinga provinces of Zambia. Interviews were audio-recorded, recordings transcribed verbatim, and transcripts were analysed using deductive thematic analysis, using the AAAQ framework and Atun's framework on integration, as a guide to reporting the findings.ResultsWe found that adolescents knew of and had access to common commodities and services- male condoms, health education and HIV counselling and testing. However, availability was affected by access-related barriers such as frequent stock-outs and insufficiently trained healthcare providers. In addition, accessibility was more restricted during the COVID-19 pandemic lockdown and compounded by the low acceptability of SRH service among adolescents across all contexts. This led to the use of alternatives such as herbal medicine and maintained common myths and misconceptions. The overall quality was marred by the lack of dedicated spaces for adolescent health services and the lack of information, education and communication (IEC) materials in some spaces.ConclusionWhile it was noted that some services were available for adolescents in all the study sites, numerous barriers inhibited access to these services and had an impact on the quality-of-service provision. With the added restriction to SRH service asses for young people, due to the low acceptability of adolescent SRH service use, the overall integration of adolescent SRH interventions into routine service provision was low and can be improved by targeting contextual barriers and maintaining best practices.
Mass Media in The Socialization of E-Government Policiesabout Online Electronic Applications Services (E- Open)
Authors: Rohmawati T , Solihin O , Mogot Y , Aulia K P 
Published: August 2024

The purpose of this study was written to find out about the mass media of e-government policy socialization through online service electronic applications (E-OPEN) at the Bekasi City population and civil registration service. The focus in this research is on the mass media socialization of e-government policies through electronic online service applications (E-OPEN) at the Bekasi City population and civil registration service. This paper is the result of research using a descriptive qualitative approach. Data collection techniques that researchers use are literature studies and field studies which are divided into three, namely observation, interviews and documentation. The technique for determining informants in this study used a purposive technique, starting from the head of the Bekasi City Disdukcapil planning department, the apparatus and admins who manage the Bekasi City Disdukcapil E-OPEN application to the public using the E-OPEN application to obtain information about mass media policy outreach to the application. E-OPEN. The results of this study indicate that the mass media used in disseminating E-Government policies through Electronic Online Services (E-OPEN) applications include Instagram @disdukcapilkotabekasi, Twitter @Disdukcapil2, Youtube Disdukcapil Kota Bekasi, Website https://disdukcapil.bekasikota. go.id. The existence of this mass media provides benefits for the people of Bekasi regarding the policies issued by the Bekasi City Government.
Adaptive Reuse of Heritage Building "Roemah Kentang 1908 Restaurant" Bandung
Authors: Maharlika F , Mutifah S Zahra 
Published: August 2024

The Roemah Kentang building is a class B cultural heritage building in Bandung. Roemah Kentang has become legendary for its horror stories. In 2020, culinary entrepreneurs renovated the old Roemah Kentang building to become a restaurant called "Roemah Kentang 1908." The transformation of the old building function into the current function is an interesting topic to research. As a result, the goal of this study is to describe how adaptive reuse was used in the "Roemah Kentang" restaurant building using conservation ethics parameters. This research uses the descriptive method with qualitative data. The result of this research is that Roemah Kentang Restaurant applies the principles of conservation ethics to the concept of adaptive reuse. The demolition and addition of the building were carried out in accordance with the needs of its current function as a restaurant, although ecologically, they do not fulfill the principles of sustainable design. The design of Roemah Kentang Restaurant is adjusted to the current socio-cultural conditions of the community so that it can support the sustainability of this restaurant economically.
Song Lyrics Translation Project in Translation Class
Authors: Ali M 
Published: August 2024

This study intends to describe the procedure of implementing a song lyrics translation project as a learning method in translation class and students' responses to this project. This research used a descriptive method with a qualitative approach. The sample of this research is 27 students who take a translation class in the 2022/2023 academic year. This study used a questionnaire as an instrument for collecting data. The results show that the song lyrics translation project was implemented in six steps, 1. Project explanation; 2. Song selection; 3. Translating by semantic translation method; 4. Translating by free translation method; 5. Presentation; 6. Evaluation. Then, from the questionnaire results, although this project is labeled as having high difficulties, there are many benefits to this project. For example, this project has a high contribution to developing students' Japanese skills, especially when it comes to vocabulary and grammar, and this song lyrics translation project become an enjoyable class activity because students have a high interest in this project. In conclusion, regarding the result, the song lyrics translation project is one feasible learning method that can be used in translation class.