bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Ligand‐Enabled Cross‐Coupling of C(sp3)—H Bonds with Arylsilanes.
Authors: He Jian , Takise Ryosuke , Fu Haiyan , Yu Jin‐Quan 
Published: August 2015

AbstractThe Pd‐catalyzed cross‐coupling of amides (I) and related carboxylic amides (IV) with arylsilicon compounds (II) is achieved at the methyl group in the presence of quinoline based ligands.
ChemInform Abstract: nBu4NI‐Catalyzed α‐Benzoxylation of Ketones with Terminal Aryl Alkenes.
Authors: Mondal Buddhadeb , Sahoo Subas Chandra , Pan Subhas Chandra 
Published: August 2015

AbstractA facile procedure for the synthesis of α‐benzoxylated ketones through in situ oxidation of styrene derivatives and subsequent coupling with propiophenones or acetophenones is developed.
ChemInform Abstract: CuBr/Proline‐Catalyzed Cross‐Coupling of Unactivated Benzene with Aryl Halides.
Authors: Liu Wei , Hou Fanyi 
Published: August 2015

AbstractVarious biaryls are efficiently obtained by radical cross‐coupling reaction between unactivated benzene (II) and aryl iodides via homolytic aromatic substitution.
ChemInform Abstract: An Efficient Aromatization of 2‐Amino‐4,5,6,7‐tetrahydrobenzo‐[b]thiophene‐3‐carboxylates in Dimethyl Sulfoxide Catalyzed by p‐Toluenesulfonic Acid.
Authors: Adib Mehdi , Soheilizad Mehd , Rajai‐daryasaraei Saideh , Mirzaei Peiman 
Published: August 2015

AbstractThe novel oxidation‐aromatization protocol furnishes benzo[b]thiophenes in excellent yields.
ChemInform Abstract: Synthesis of 2‐Trifluoromethyl Indoles via Visible‐Light Induced Intramolecular Radical Cyclization.
Authors: Dong Xichang , Hu Yumin , Xiao Tiebo , Zhou Lei 
Published: August 2015

Abstractof N‐(2‐alkynylphenyl)trifluoroacetimidoyl chlorides
ChemInform Abstract: Organocatalytic Asymmetric Michael Addition of Benzofuran‐2(3H)‐ones to Alkylideneindolenines Generated in situ from Arenesulfonylalkylindoles.
Authors: Wang Rongming , Jing Linhai , Qin Dabin 
Published: August 2015

AbstractThe title process allows the synthesis of a series of optically active indole derivatives with enantioselectivities up to 94%.
ChemInform Abstract: Iodine‐Catalyzed C3‐Formylation of Indoles via C—N Bond Cleavage of Tertiary Amines under Aerobic Conditions.
Authors: Lu Lin , Xiong Qiheng , Guo Shengmei , He Tianqiang , Xu Feng , Gong Jiuhan , Zhu Zheng , Cai Hu 
Published: August 2015

AbstractThe reaction yield depends on the electronic properties of the substrates′ substituents.
ChemInform Abstract: Oxidative Photochemical Cyclization of Ethyl 3‐(Indol‐3‐yl)‐3‐oxo‐2‐phenylpropanoate Derivatives: Synthesis of Benzo[a]carbazoles.
Authors: Li Yinlong , Pang Zhonghua , Zhang Tianqi , Yang Jidong , Yu Wei 
Published: August 2015

AbstractA series of benzo[a]carbazoles (IV) is readily prepared by oxidative photochemical cyclization of readily available ketones (III).
ChemInform Abstract: Diastereoselective Synthesis of Pyrroloindolines Using α,β‐Unsaturated N‐Aryl Ketonitrones and Activated Alkynes.
Authors: Huehls C. Bryan , Huang Jinhua , Yang Jiong 
Published: August 2015

AbstractThe de novo one‐step synthesis provides structurally complex pyrroloindolines in low to moderate yields.
ChemInform Abstract: Facile Synthesis and Stereo‐Resolution of Chiral 1,2,3‐Triazoles.
Authors: Shi Ye , Ye Xiaohan , Gu Qiang , Shi Xiaodong , Song Zhiguang 
Published: August 2015

AbstractLipase‐catalyzed kinetic resolution of readily available functionalized triazoles (VI) and (VII) provides enantiomerically pure chiral triazoles, which are successfully applied as ligands in the asymmetric addition of Et2Zn to aromatic aldehydes (IX).
ChemInform Abstract: Synthesis of Rigid Analogues of Flavone by Intramolecular Heck Reaction.
Authors: Hou Chuanwei , Chen Hao , Xu Xing , Zhu Fangxia , Guo Lei , Jiang Min , Yang Chunhao , Deng Lianfu 
Published: August 2015

AbstractThe novel concise method for the synthesis of flavone analogues is based on an intramolecular Heck reaction of key precursors (I) and (III).
ChemInform Abstract: Tandem Prins Cyclization for the Stereoselective Synthesis of the 4,5‐Diaryl‐hexahydropyrano[3,4‐c]chromene Skeleton of Calyxins I and J.
Authors: Reddy Basi V. Subba , Reddy Mittapalli Ramana , Reddy Sama Gopal , Sridhar Balasubramanyan , Kumar Singarapu Kiran 
Published: August 2015

AbstractThis novel Prins bicyclization strategy allows the stereoselective synthesis of various trans‐fused chromene derivatives (III) and product (V) possessing the core structure of calyxins I and J.
ChemInform Abstract: Direct Access to Functionalized Benzotropones, Azepanes, and Piperidines by Reductive Cross‐Coupling of α‐Bromo Enones with α‐Bromo Enamides.
Authors: Beng Timothy K. , Sincavage Kayla , Silaire Ann Wens V. , Alwali Amir , Bassler Daniel P. , Spence Laura E. , Beale Oliver 
Published: August 2015

Abstractunder cobalt catalysis
ChemInform Abstract: Tandem Arylation/Friedel—Crafts Reactions of o‐Acylanilines with Diaryliodonium Salts: A Modular Synthesis of Acridine Derivatives.
Authors: Pang Xinlong , Lou Zhenbang , Li Ming , Wen Lirong , Chen Chao 
Published: August 2015

AbstractA modular method to synthesize acridine derivatives is developed with ortho‐acylanilines and diaryliodonium salts.
ChemInform Abstract: Palladium‐Catalyzed Three‐Component Cascade Reaction: Facial Access to Densely Functionalized Indolizines.
Authors: Liu Ren‐Rong , Lu Chuan‐Jun , Zhang Ming‐Di , Gao Jian‐Rong , Jia Yi‐Xia 
Published: August 2015

AbstractStarting from 2‐(2‐enynyl)pyridines, allyl chlorides, and malonates or indole derivatives as nucleophiles a general route to 1,2,3‐trisubstituted indolizines is elaborated which provides the products in moderate to high yields.
ChemInform Abstract: Two New Flavonoids from Retama raetam.
Authors: Xu Wen‐Hui , Al‐Rehaily Adnan J. , Yousaf Muhammad , Ahmad Mohammad S. , Khan Shabana I. , Khan Ikhlas A. 
Published: August 2015

AbstractThe two new furanoflavonoids retamasin A (I) and B (II) are isolated from the aerial parts of Retama raetam together with five known compounds.
ChemInform Abstract: 1,8‐Diazabicyclo[5.4.0]undec‐7‐ene (DBU): A Versatile Reagent in Organic Synthesis
Authors: Nand Bhaskara , Khanna Garima , Chaudhary Ankita , Lumb Anshika , Khurana Jitender M. 
Published: August 2015

AbstractReview: 122 refs.
Kinetically Tunable Photostability of Fluorogen‐Activating Peptide–Fluorogen Complexes
Authors: Saurabh Saumya , Zhang Ming , Mann Victor R. , Costello Andrea M. , Bruchez Marcel P. 
Published: August 2015

AbstractEase of genetic encoding, labeling specificity, and high photostability are the most sought after qualities in a fluorophore for biological detection. Furthermore, many applications can gain from the fluorogenic nature of fluoromodules and the ability to turn on the same fluoromodules multiple times. Fluorogen‐activating peptides (FAPs) bind noncovalently to their cognate fluorogens and exhibit enhanced photostability. Herein, the photostabilities of malachite green (MG)‐binding and thiazole‐orange‐binding FAPs are compared under limiting‐ and excess‐fluorogen conditions to establish distinct mechanisms for photostability that correspond to the dissociation rate of the FAP–fluorogen complex. FAPs with slow dissociation show evidence of dye encapsulation and protection from photo or environmental degradation and single‐step bleaching at the single molecule level, whereas those with rapid dissociation show repeated cycles of binding and enhanced photostability by exchange of bleached fluorogen with a new dye. A combination of generalizable selection pressure based on bleaching, flow cytometry, and site‐specific amino acid mutagenesis is used to obtain a modified FAP with enhanced photostability, due to rapid dissociation of the MG fluorogen. These studies shed light on the basic mechanisms by which noncovalent association can effect photostable labeling, and demonstrate novel reagents for photostable and intermittent labeling of biological targets.
State of the art systematic review of bone disease in anorexia nervosa
Authors: Misra Madhusmita , Golden Neville H. , Katzman Debra K. 
Published: August 2015

ABSTRACTObjectiveLow bone mineral density (BMD) is a known consequence of anorexia nervosa (AN) and is particularly concerning during adolescence, a critical time for bone accrual. A comprehensive synthesis of available data regarding impaired bone health, its determinants, and associated management strategies in AN is currently lacking. This systematic review aims to synthesize information from key physiologic and prospective studies and trials, and provide a thorough understanding of impaired bone health in AN and its management.MethodSearch terms included “anorexia nervosa” AND “bone density” for the period 1995–2015, limited to articles in English. Papers were screened manually based on journal impact factor, sample size, age of participants, and inclusion of a control group. When necessary, we included seminal papers published before 1995.ResultsAN leads to low BMD, impaired bone quality and increased fracture risk. Important determinants are low lean mass, hypogonadism, IGF‐1 deficiency, and alterations in other hormones that impact bone health. Weight gain and menses restoration are critical for improving bone outcomes in AN. Physiologic estrogen replacement as the transdermal patch was shown to increase bone accrual in one study in adolescent females with AN; however, residual deficits persist. Bisphosphonates are potentially useful in adults with AN.DiscussionTo date, evidence suggests that the safest and most effective strategy to improve bone health in AN is normalization of weight with restoration of menses. Pharmacotherapies that show promise include physiologic estradiol replacement (as the transdermal estradiol patch), and in adults, bisphosphonates. Further studies are necessary to determine the best strategies to normalize BMD in AN.
Improving postoperative pain management in children by providing regular training and an updated pain therapy concept
Authors: Heinrich M. , Mechea A. , Hoffmann F. 
Published: August 2015

AbstractBackgroundIn recent years, children's hospitals have increasingly implemented postoperative pain management protocols to reduce postoperative pain and improve patient satisfaction. The effectiveness and long‐term sustainability of such protocols have rarely been studied. Therefore, we conducted a prospective intervention study to assess the impact of regular training and improvement of clinical processes on the quality of postoperative pain management.MethodsWe conducted an initial assessment of the status quo of postoperative pain management (Audit 1) followed by repeated training and improvement of clinical processes (analgesic pocket card, parents’ brochure, modification of the patient chart, bimonthly advanced trainings sessions) and a follow‐up review after 3 years (Audit 2). We used a data entry form, a patient survey, and an anonymous questionnaire for the nursing staff as measurement tools.ResultsOur analysis included a total of 93 and 85 patients in the initial and final audits. The return rates of the nursing staff questionnaire were 83% (Audit 1) and 77% (Audit 2). The training and process improvements resulted in significant improvement in the administration of analgesics for pain requiring treatment, the control of pain measurement after the administration of analgesics and the use of non‐pharmacological pain therapies. The patients reported faster administration of analgesics for acute pain and improved pain relief following the intervention.ConclusionsRepeated training and improvement of clinical processes can significantly improve the long‐term quality of postoperative pain management in children with a tolerable amount of effort on the part of health care professionals and institutions.
Experimental study on the bidirectional inelastic deformation capacity of U‐shaped steel dampers for seismic isolated buildings
Authors: Ene Diana , Kishiki Shoichi , Yamada Satoshi , Jiao Yu , Konishi Yoshinao , Terashima Masao , Kawamura Norihisa 
Published: August 2015

SummaryHysteretic dampers are used to dissipate earthquake‐induced energy in base‐isolated structures by acquiring inelastic deformations, rendering their hysteretic behavior of vital importance. The present paper focuses on investigating the behavior of U‐shaped steel dampers under bidirectional loading; this is significantly different from their corresponding uniaxial behavior. Two main sets of loading tests on full‐scale specimens are conducted in this regard: (i) quasi‐static tests with simple histories and (ii) dynamic tests with realistic loading histories. Based on the results obtained in the quasi‐static tests, an interaction curve that accounts for the reduction of the cyclic deformation capacity is proposed. However, the fidelity of this relation must be assessed under loading conditions similar to those of a seismically isolated structure subjected to an earthquake, which represents the goal of the second set of tests. The results of the dynamic tests validate the proposed interaction curve for estimating the deformation capacity of U‐shaped steel dampers under bidirectional loading. Copyright © 2015 John Wiley & Sons, Ltd.
Field degradation of aminopyralid and clopyralid and microbial community response to application in Alaskan soils
Authors: Tomco Patrick L. , Duddleston Khrystyne N. , Schultz Emily Jo , Hagedorn Birgit , Stevenson Timothy J. , Seefeldt Steven S. 
Published: August 2015

Abstract

High-latitude regions experience unique conditions that affect the degradation rate of agrochemicals in the environment. In the present study, data collected from 2 field sites in Alaska, USA (Palmer and Delta) were used to generate a kinetic model for aminopyralid and clopyralid degradation and to describe the microbial community response to herbicide exposure. Field plots were sprayed with herbicides and sampled over the summer of 2013. Quantification was performed via liquid chromatrography/tandem mass spectrometry, and microbial diversity was assessed via next-generation sequencing of bacterial 16S ribosomal ribonucleic acid (rRNA) genes. Both compounds degraded rapidly via pseudo-first–order degradation kinetics between 0 d and 28 d (t1/2 = 9.1–23.0 d), and then degradation slowed thereafter through 90 d. Aminopyralid concentration was 0.048 μg/g to 0.120 μg/g at 90 d post application, whereas clopyralid degraded rapidly at the Palmer site but was recovered in Delta soil at a concentraction of 0.046 μg/g. Microbial community diversity was moderately impacted by herbicide treatment, with the effect more pronounced at Delta. These data predict reductions in crop yield when sensitive plants (potatoes, tomatoes, marigolds, etc.) are rotated onto treated fields. Agricultural operations in high-latitude regions, both commercial and residential, rely heavily on cultivation of such crops and care must be taken when rotating. Environ Toxicol Chem 2016;35:485–493. © 2015 SETAC
In vitro M‐like cells genesis through a tissue‐engineered triple‐culture intestinal model
Authors: Araújo Francisca , Pereira Carla , Costa Joana , Barrias Cristina , Granja Pedro L. , Sarmento Bruno 
Published: August 2015

AbstractAlthough fewer in number, M‐cells are considered antigen sampling cells, acting as a gateway for antigens from the gut lumen and presenting an impressive aptitude for particle transcytosis. These features make M‐cells attractive targets for oral drug delivery studies, but this has been poorly explored. New and reproducible tissue‐like in vitro models for studying intestinal sampling and permeability mechanisms are needed. The combination of different cell players in such models offers improved microenvironments with higher physiologic relevance. Here, a tissue‐engineered model was established, by co‐culturing Caco‐2 absorptive cells, HT29‐MTX mucus‐producing cells and Raji B lymphocytes. After 3 weeks of cell co‐culture, the presence of M‐like cells was evidenced by the loss of brush‐border organization, detected by the lack of microvilli. The triple‐culture model showed to be efficient for insulin transport, a process that was influenced by the tightness of junctions between epithelial cells and the presence of mucus and M‐like cells. Ultimately, the proposed tissue‐engineered model provides a more complete and reliable tool to perform drug permeability tests, as compared to traditional models, and may also find applicability as an in vitro system to study transdifferentiation mechanisms of M cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 104B:782–788, 2016.
A New Practical Route to ZSM‐5 Nanoparticles and Optimization of Synthetic Parameters through D‐optimal Design of Experiments
Authors: Soltanali Saeed , Halladj Rouein , Rashidi Alimorad , Bazmi Mansour , Khodabakhshi Saeed 
Published: August 2015

AbstractA D‐optimal experimental design with three levels of SiO2/Al2O3, template/SiO2, H2O/SiO2, Na2O/SiO2 and TPABr/TPAOH ratio parameters has been used to optimize the experimental parameters by an analysis of variances (ANOVA). The effects of these ratios in the initial synthetic mixture on the size of the ZSM‐5 zeolite nanoparticles have been studied. XRD and FE‐SEM analyses were used to characterize synthetic samples. Fischer test results showed that H2O/SiO2 and TPABr/TPAOH ratios are the most and least effective parameters, respectively, in the range studied. The most important two‐way interaction variables were the interaction of template/SiO2 and TPABr/TPAOH molar ratios. The average particle size was in the 34–79 nm range. Furthermore, a mathematical model for the synthesis of ZSM‐5 zeolite nanoparticles was derived using experimental results. The optimized gel composition is as follows: SiO2/Al2O3=91.20, template/SiO2=0.16, H2O/SiO2=40.42, Na2O/SiO2=0.0147 and TPABr/TPAOH=0.
Diorganotin(IV) Complexes with Monohydrate Disodium Salt of Iminodiacetic Acid: Synthesis, Characterization, Crystal Structure and Biological Activities
Authors: Hussain Shabbir , Ali Saqib , Shahzadi Saira , Rizzoli Corrado , Shahid Muhammad 
Published: August 2015

AbstractDiorganotin(IV) derivatives have been synthesized by the reaction of R2SnL2 (R=n‐Bu 1, Ph 2) with monohydrate disodium salt of iminodiacetic acid (Na2L) in 1 : 1 M/L ratio under reflux conditions. The compounds have been characterized by FT‐IR, NMR (1H and 13C) spectoscopy, electron ionization mass spectrometry (EIMS), thermogravimetric analyses (TGA) and single crystal XRD. FTIR data indicates a mono‐dentate binding mode of the carboxylic acid group as well as participation of the amino nitrogen and aqua oxygen in coordination with organotin(IV) moieties. NMR data demonstrates a tetra‐coordinated environment around tin(IV) in solution. Mass spectrometric and thermogravimetric analyses verify the close similarities between the molecular structures of both complexes. The thermal stability of diphenyltin(IV) derivative (2) was found slightly higher than that of the free ligand (Na2L). Single crystal X‐ray analysis of the complex 1 have shown a hexa‐coordinated geometry around Sn(IV) with trans configuration. There are evidences for the existence of intermolecular hydrogen bonding in the structure of the complexes. The products displayed significant antibacterial and antifungal activities in contrast to the biologically inactive ligand precursor. However, the hemolytic cytoxicity of the complexes was comparatively high than the free ligand.
Comparison of Loading Efficiency between Hyperbranched Polymers and Cross‐Linked Nanogels at Various Branching Densities
Authors: Graff Robert W. , Shi Yi , Wang Xiaofeng , Gao Haifeng 
Published: August 2015

The effect of branching point structures and densities is studied between azido‐containing hyperbranched polymers and cross‐linked nanogels on their loading efficiency of alkynyl‐containing dendron molecules. Hyperbranched polymers that contained “T”‐shaped branching linkage from which three chains radiated out and cross‐linked nanogels that contained “X”‐shaped branching linkage with four radiating chains are synthesized in microemulsion using either atom transfer radical polymerization (ATRP) or conventional radical polymerization (RP) technique. Both polymers have similar density of azido groups in the structure and exhibit similar hydrodynamic diameter in latexes before purification. Subsequent copper‐catalyzed azide–alkyne cycloaddition reactions between these polymers and alkynyl‐containing dendrons in various sizes (G1–G3) demonstrate an order of dendron loading efficiencies (i.e., final conversion of alkynyl‐containing dendron) as hyperbranched polymers > nanogels synthesized by ATRP > nanogels synthesized by RP. Decreasing the branching density or using smaller dendron molecules increases the click efficiency of both polymers. When G2 dendrons with a molecular weight of 627 Da are used to click with the hyperbranched polymers composed of 100% inimer, a maximum loading efficiency of G2 in the loaded hyperbranched polymer is 58% of G2 by weight. These results represent the first comparison between hyperbranched polymers and cross‐linked nanogels to explore the effect of branching structures on their loading efficiencies.
image
The Significance and Therapeutic Potential of GATA3 Expression and Mutation in Breast Cancer: A Systematic Review
Authors: Du Feng , Yuan Peng , Wang Teng , Zhao Jiuda , Zhao Zitong , Luo Yang , Xu Binghe 
Published: August 2015

AbstractGATA3 is a critical transcription factor in the development of various human systems. The notion that GATA3 expression is required for the differentiation and maintenance of normal breast tissue has been well established. Recently, GATA3 is found to actively participate in the multistep process leading breast cancer pathogenesis, including tumorigenesis, tumor differentiation, epithelial mesenchymal transition, and metastasis through regulation of various target genes. On the other hand, several studies have raised questions and highlighted the role of GATA3‐low or GATA3‐negative cells during the malignant development of breast cancer. In addition to gene expression, GATA3 mutations provide another dimension of complexity. As one of the most frequently mutated genes in breast cancer, GATA3 mutations may have an effect on DNA‐binding ability, protein production, and transactivation activity. Recognition of the multiple function of GATA3 in breast cancer will serve to deepen our understanding of the nature of this disease and develop novel therapeutic approaches.
Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway
Authors: Trung Ly Quoc , Espinoza J. Luis , An Dao T. , Viet Nguyen Hoang , Shimoda Kazuya , Nakao Shinji 
Published: August 2015

ScopeResveratrol is a natural occurring polyphenol with several health promoting activities, including anticancer potential. Here, we analyzed the cytotoxic effects of resveratrol against malignant cells characterized by aberrant activation of the Janus kinase 2 (JAK2).Methods and resultsCell‐cycle analysis, proliferation, apoptosis, and Western blotting assays were performed to study the effect of resveratrol on malignant cells exhibiting an excessive activation of the JAK2 pathway secondary to the JAK2V617F mutation. Resveratrol inhibited proliferation and induced apoptosis in JAK2V617F mutant tumor cells and its selectivity was 1.5–6.9 times greater than that observed in other tumor cells without the JAK2V617F mutation. In addition, resveratrol inhibited the phosphorylation of JAK1, JAK2, and Tyk2 and their downstream mediators, including STAT3 and STAT5. In primary cultures, resveratrol treatment inhibited erythroid progenitor colony formation in blood samples obtained from JAK2V617F polycythemia vera patients. Moreover, resveratrol synergized with the selective JAK2 inhibitor ruxolitinib, eliminating tumor cells with the JAK2 mutation.ConclusionResveratrol may have therapeutic potential against myeloproliferative neoplasms associated with the aberrant activation of the JAK2 pathway.