bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Thiazolo[3,4‐b]indazole‐2,2‐dioxides as Masked Extended Dipoles: Pericyclic Reactions of Benzodiazafulvenium Methides.
Authors: Soares Maria I. L. , Nunes Claudio M. , Gomes Clara S. B. , Pinho e Melo Teresa M. V. D. 
Published: May 2013

AbstractFirst examples of 1,3‐dipolar cycloadditions of thiazolidine‐derived sydnones with in situ generated benzyne lead to dihydrothiazolo[3,4‐b]indazoles (III) which are further converted into sulfones (IV).
ChemInform Abstract: Pd‐Catalyzed Coupling Reaction of Fluorinated Propargyl Amidines with Aryl Iodides
Authors: Li Shan , Yuan Yafen , Li Yajun , Li Zhengke , Zhang Lisi , Wu Yongming 
Published: May 2013

Abstractleading to 2,5‐disubstituted N‐arylimidazoles
ChemInform Abstract: CuO Nanoparticles Supported on Silica: A New Catalyst for Facile Synthesis of Benzimidazoles, Benzothiazoles and Benzoxazoles.
Authors: Inamdar Suleman M. , More Vinod K. , Mandal Sisir K. 
Published: May 2013

AbstractIt is demonstrated that the condensations proceed with high efficiency in a short reaction time.
ChemInform Abstract: C—H Bonds as Ubiquitous Functionality: Preparation of Multiple Regioisomers of Arylated 1,2,4‐Triazoles via C—H Arylation.
Authors: Joo Jung Min , Guo Pengfei , Sames Dalibor 
Published: May 2013

AbstractSimilar reactions can also be performed with THP instead of SEM as protecting group on the triazole substrate.
ChemInform Abstract: One‐Pot Synthesis of Bis(amino)‐1,2,4‐thiadiazoles via Direct SNAr.
Authors: Beeley Howard A. , Degorce Sebastien , Harris Craig S. , Lecoq Jonathan , Morgentin Remy , Perkins David 
Published: May 2013

AbstractThe selective SNAr reaction of dichloro‐1,2,4‐thiadiazole with amines at the 5‐position can be easily combined with a second SNAr reaction to produce unsymmetrically disubstituted 3,5‐bis(amino)‐1,2,4‐thiadiazole libraries.
ChemInform Abstract: A Cascade Reaction Actuated by Nucleophilic Heterocyclic Carbene Catalyzed Intramolecular Addition of Enals via Homoenolate to α,β‐Unsaturated Esters: Efficient Synthesis of Coumarin Derivatives.
Authors: Sinu C. R. , Padmaja D. V. M. , Ranjini U. P. , Lakshmi K. C. Seetha , Suresh Eringathodi , Nair Vijay 
Published: May 2013

AbstractComparable yields of (II) are obtained regardless whether the E/Z‐mixtures of the substrates are used or pure isomers.
ChemInform Abstract: Reactions of 3‐Acylchromones with Dimethyl 1,3‐Acetonedicarboxylate and 1,3‐Diphenylacetones: One‐Pot Synthesis of Functionalized 2‐Hydroxybenzophenones, 6H‐Benzo[c]chromenes and Benzo[c]coumarins.
Authors: Iaroshenko Viktor O. , Savych Iryna , Villinger Alexander , Sosnovskikh Vyacheslav Ya. , Langer Peter 
Published: May 2013

AbstractThe reaction path strongly depends on the substitution pattern at the keto‐group of the starting chromone derivatives.
ChemInform Abstract: Highly Efficient One‐Pot Amination of Carboxylate‐Substituted Nitrogen‐Containing Heteroaryl Chlorides via Staudinger Reaction.
Authors: Kandalkar Sachin R. , Kaduskar Rahul D. , Ramaiah Parimi Atchuta , Barawkar Dinesh A. , Bhuniya Debnath , Deshpande Anil M. 
Published: May 2013

AbstractChloropyridines and analogues are converted to the corresponding amino derivatives by azidation followed by Staudinger reaction and subsequent mild acidic hydrolysis.
ChemInform Abstract: Lewis Acid Catalyzed Csp3—H Functionalization of Methyl Azaarenes with α‐Trifluoromethyl Carbonyl Compounds.
Authors: Graves Vincent B. , Shaikh Abid 
Published: May 2013

AbstractYtterbium triflate is found to be highly efficient for the title reaction, delivering trifluormethylated alcohols in excellent yields.
ChemInform Abstract: Addition/Elimination Reactions of Ethylsulfonyl Pyridines: Stereoselective Synthesis of Vinylpyridine Allylic Alcohols.
Authors: O'Neil Gregory W. , Drake Nathan D. , Storvick Jennifer M. 
Published: May 2013

AbstractLithiation of pyridylethyl sulfones (I) and (X) with excess BuLi and subsequent addition of a variety of aldehydes results in direct formation of sulfone‐eliminated vinylpyridine allylic alcohols in high or complete (E)‐selectivity.
ChemInform Abstract: A Unique and Simple Preparative Method for α‐Arylpipecolinic Acid Esters via Base‐Induced Sommelet—Hauser Rearrangement.
Authors: Tayama Eiji , Sato Ryota , Ito Motoshi , Iwamoto Hajime , Hasegawa Eietsu 
Published: May 2013

AbstractTitle compounds such as (V) and (IX) are prepared via a new three‐step sequence including base‐induced Sommelet—Hauser rearrangement, subsequent von Braun reaction and intramolecular α‐alkylation.
ChemInform Abstract: Per‐6‐amino‐β‐cyclodextrin as a Chiral Base Catalyst Promoting One‐Pot Asymmetric Synthesis of 2‐Aryl‐2,3‐dihydro‐4‐quinolones.
Authors: Kanagaraj Kuppusamy , Pitchumani Kasi 
Published: May 2013

AbstractThe catalyst can be easily recovered by filtration and reused several times without significant loss of activity.
ChemInform Abstract: NHC‐Catalyzed Cascade Synthesis of 1‐Substituted 4‐Aryl‐tetrahydroquinoline‐2,5‐diones.
Authors: Yao Changsheng , Jiao Weihui , Xiao Zhaoxin , Liu Rui , Li Tuanjie , Yu Chenxia 
Published: May 2013

AbstractN‐Heterocyclic carbene (NHC)‐catalyzed organocascade reactions via redox processes are found to be a simple and flexible procedure for the synthesis of title compounds (III).
ChemInform Abstract: Rhodium(III)‐Catalyzed Oxidative C—H Coupling of N‐Methoxybenzamides with Aryl Boronic Acids: One‐Pot Synthesis of Phenanthridinones.
Authors: Karthikeyan Jaganathan , Haridharan Radhakrishnan , Cheng Chien‐Hong 
Published: May 2013

AbstractThe reaction proceeds with high regioselectivity under mild conditions to afford a broad spectrum of substituted title compounds through C—C and C—N coupling.
ChemInform Abstract: Microwave‐Assisted Westphal Condensation and Its Application to Synthesis of Sempervirine and Related Compounds.
Authors: Rao T. S. Chinta , Saha Sanjay , Raolji Gajendra B. , Patro Balaram , Risbood Prabhaker , Difilippantonio Michael J. , Tomaszewski Joseph E. , Malhotra Sanjay V. 
Published: May 2013

AbstractWestphal condensation of pyridoindolium bromide (I) with 1,2‐cyclohexadione followed by ester hydrolysis and decarboxylation provides title compound (IIIa), a potent lead in anticancer therapeutics.
ChemInform Abstract: Pyrrole versus Quinoline Formation in the Palladium Catalyzed Reaction of 2‐Alkynyl‐3‐bromothiophenes and 2‐Alkynyl‐3‐bromofurans with Anilines. A Combined Experimental and Computational Study.
Authors: Salman Ghazwan Ali , Nisa Riffat Un , Iaroshenko Viktor O. , Iqbal Jamshed , Ayub Khurshid , Langer Peter 
Published: May 2013

AbstractBenzofuroquinolines and furoquinolines are prepared in one‐step from 2‐alkynyl‐3‐bromobenzofurans and 2‐alkynyl‐3‐bromofurans and electron‐rich anilines, respectively, by a Pd‐catalyzed domino C—N coupling/annulation process.
ChemInform Abstract: Synthesis of Some Novel Binuclear Heterocyclic Compounds from 6‐Ethyl‐3‐nitropyrano[3,2‐c]quinoline‐4,5(6H)‐dione.
Authors: Hassanin Hany M. , Abdel‐Kader Dalia 
Published: May 2013

AbstractTitle compound (III) is prepared and its reactivity towards a series of binucleophilic reagents is investigated.
ChemInform Abstract: Auto‐Tandem Catalysis: Synthesis of 4H‐Pyrido[1,2‐a]pyrimidin‐4‐ones via Copper‐Catalyzed Aza‐Michael Addition—Aerobic Dehydrogenation—Intramolecular Amidation.
Authors: Yang Yan , Shu Wen‐Ming , Yu Shang‐Bo , Ni Fan , Gao Meng , Wu An‐Xin 
Published: May 2013

AbstractA novel copper‐catalyzed synthesis of pyridopyrimidinones from 1,4‐enediones and 2‐amino‐heterocycles is developed.
ChemInform Abstract: Unexpected Approach to the Synthesis of 2‐Phenylquinoxalines and Pyrido[2,3‐b]pyrazines via a Regioselective Reaction.
Authors: Alizadeh Abdolali , Mokhtari Javad 
Published: May 2013

AbstractAttempts to obtain spiro‐compounds of type (IV) via multicomponent reaction of phosphoranylideneethanone (I) with isatin and aromatic o‐diamines result in the unexpected formation of fused pyrazine derivatives [cf.
ChemInform Abstract: Novel Condensation of Nitroacetic Esters with Aromatic Aldehydes Leading to 5‐Hydroxy‐1,2‐oxazin‐6‐ones.
Authors: Baranov Mikhail S. , Yampolsky Ilia V. 
Published: May 2013

AbstractContrary to a previous report, the reaction of nitroacetate with aromatic aldehydes in the presence of dialkylamines is found to generate the oxazinones (IV).
ChemInform Abstract: Direct Esterification of Phosphinic Acids under Microwave Conditions: Extension to the Synthesis of Thiophosphinates and New Mechanistic Insights.
Authors: Keglevich Gyoergy , Kiss Nora Zsuzsa , Drahos Laszlo , Koertvelyesi Tamas 
Published: May 2013

AbstractA simple procedure allows the direct esterification with thiols and benzyl alcohols.
ChemInform Abstract: Synthesis of Chiral β‐Iodo‐ and Vinylorganophosphorus(V) Compounds by Fragmentation of Carbohydrate Anomeric Alkoxyl Radicals.
Authors: Hernandez‐Guerra Daniel , Rodriguez Maria S. , Suarez Ernesto 
Published: May 2013

AbstractDesired phosphapentofuranoses, e.g. (X) and (XII), are prepared via a carbohydrate anomeric alkoxyl radical β‐fragmentation reaction of hexapyranoses such as (V) with iodine as key step.
ChemInform Abstract: Convenient Methods for the Synthesis of Chiral Amino Alcohols and Amines
Authors: Periasamy Mariappan , Gurubrahamam Ramani , Sanjeevakumar Nalluri , Dalai Manasi , Alakonda Laxhmaiah , Reddy Polimera Obula , Suresh Sundaram , Satishkumar Sakilam , Padmaja Meduri , Reddy Meda Narsi , et al. et al. 
Published: May 2013

AbstractReview: 132 refs.
A Prospective Randomized Study Comparing Isolation of the Arrhythmogenic Vein Versus All Veins in Paroxysmal Atrial Fibrillation
Authors: Fichtner Stephanie , Hessling Gabriele , Ammar Sonia , Reents Tilko , Estner Heidi L. , Jilek Clemens , Kathan Susanne , Büchner Michael , Dillier Roger , Deisenhofer Isabel 
Published: May 2013

AbstractBackgroundAblation procedures in patients with paroxysmal atrial fibrillation (PAF) includes isolation of all pulmonary veins (PVs). We hypothesized that an approach using an algorithm to detect arrhythmogenic PVs (aPVs) might lead to shorter procedure duration (PD) and fewer proarrhythmic effects (PE).HypothesisIsolation of the aPVs only leads to a reduced PD, reduced PEs, and fewer adverse events, with a success rate comparable to the standard all‐PV approach.MethodsIn this prospective trial, 207 patients with PAF were randomized to undergo isolation of the aPV (AG group, n = 105) or isolation of all PVs (VG group, n = 102). The aPV was identified by atrial fibrillation (AF) induction, focal discharge, or short local PV decremental conduction during PV pacing. Patients were followed with repetitive 7‐day Holter electrocardiograms (ECGs) after 3, 6, and 12 months in our arrhythmia clinic.ResultsIn 97% of patients, at least 1 aPV was identified (mean, 2.1). PD did not differ significantly (152.3 ± 57.1 minutes vs 162 ± 68 minutes, P = 0.27) between the groups, but the number of radiofrequency (RF) applications and fluoroscopy time (FT) and dose were significantly lower in the AG group than in the VG group. The occurrence of PE (new‐onset atrial tachycardia) and adverse events (AE) did not differ between the 2 groups (P = 0.1). Sinus rhythm off antiarrhythmic medication (documented on 7‐day Holter ECGs) 12 months after a single procedure was achieved in 53% in the AG group and 59% in the VG group (P = 0.51).ConclusionsIsolation of the aPVs detected by a straightforward algorithm leads to similar success rates compared to a standard all‐PV approach with regard to PD, AE, or PE and is associated with less RF and a shorter FT.
Impact of Smoking Status on Cardiovascular Outcomes Following Percutaneous Coronary Intervention
Authors: Mohamedali Burhan , Shroff Adhir 
Published: May 2013

AbstractBackgroundMany military veterans in the United States with coronary artery disease continue to smoke despite undergoing percutaneous coronary intervention (PCI). Previous studies have described improved cardiovascular outcomes in smokers, the so‐called “smokers' paradox.” In this study, we examined the effects of smoking on cardiovascular outcomes following PCI.HypothesisDo patients who smoke have different post‐PCI outcomes than nonsmokers?MethodsAll patients who underwent PCI at a single US Veterans Administration hospital from 2004 to 2009 were followed. Outcomes of interest included myocardial infarction, unplanned coronary intervention, unplanned cardiac hospitalization, death, and a composite of events for 6 months after PCI. Changes in traditional risk factors were also assessed.ResultsUnadjusted analysis revealed that in almost all categories, smokers had lower incidence of adverse events than nonsmokers. However, after adjusting for the older age of the nonsmokers, no favorable statistical trend toward smokers was seen. Significant improvement in blood pressure and lipid levels were seen in both groups.ConclusionsAfter adjusting for differences in age, there did not appear to be any protective effect of smoking on cardiovascular outcomes following PCI. Smokers achieved similar degrees of risk factor optimization during the follow‐up period as their nonsmoker counterparts. Aggressive efforts to decrease the prevalence of smoking must be maintained.
The Lab Oddity Prevails: Discovery of Pan‐CDK Inhibitor (R)‐S‐Cyclopropyl‐S‐(4‐{[4‐{[(1R,2R)‐2‐hydroxy‐1‐methylpropyl]oxy}‐5‐(trifluoromethyl)pyrimidin‐2‐yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer
Authors: Lücking Ulrich , Jautelat Rolf , Krüger Martin , Brumby Thomas , Lienau Philip , Schäfer Martina , Briem Hans , Schulze Julia , Hillisch Alexander , Reichel Andreas , Wengner Antje Margret , Siemeister Gerhard 
Published: May 2013

AbstractLead optimization of a high‐throughput screening hit led to the rapid identification of aminopyrimidine ZK 304709, a multitargeted CDK and VEGF‐R inhibitor that displayed a promising preclinical profile. Nevertheless, ZK 304709 failed in phase I studies due to dose‐limited absorption and high inter‐patient variability, which was attributed to limited aqueous solubility and off‐target activity against carbonic anhydrases. Further lead optimization efforts to address the off‐target activity profile finally resulted in the introduction of a sulfoximine group, which is still a rather unusual approach in medicinal chemistry. However, the sulfoximine series of compounds quickly revealed very interesting properties, culminating in the identification of the nanomolar pan‐CDK inhibitor BAY 1000394, which is currently being investigated in phase I clinical trials.
Water and Protein Dynamics in Sedimented Systems: A Relaxometric Investigation
Authors: Luchinat Claudio , Parigi Giacomo , Ravera Enrico 
Published: May 2013

AbstractSedimented proteins have recently been shown to provide solid‐state NMR spectra of high quality, suitable for structural investigation. This is ascribed to the strong self‐crowding effect, which apparently increases the reorientation time up to the point that the protein can be considered immobile on the NMR timescale. Herein, a relaxometric investigation of sedimented bovine serum albumin is performed to obtain information on the dynamics of the system. The measurement of the proton longitudinal relaxation rates as a function of the applied magnetic field indicates that the sedimented protein has relaxation properties very different from those of the protein in concentrated water solutions, even in the presence of glycerol, and similar to those of slightly rehydrated lyophilized systems. This study confirms the hypothesis that the reorientation of the protein molecules is largely abolished in sediments.
9‐Fluorenone‐2‐Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds
Authors: Calogero Francesco , Borrelli Stella , Speciale Gaetano , Christodoulou Michael S. , Cartelli Daniele , Ballinari Dario , Sola Francesco , Albanese Clara , Ciavolella Antonella , Passarella Daniele , Cappelletti Graziella , Pieraccini Stefano , Sironi Maurizio 
Published: May 2013

AbstractThe introduction of a hydrophobic group at position 7 of 9‐fluorenone‐2‐carboxylic acid generates new tubulin binders, the design of which is suggested by modeling studies. The synthesis is based on the use of 2,7‐dibromo‐fluorenone as starting material. The antiproliferative activity on two different cell lines, fluorescent microscopy, flow cytometry, and sedimentation assay tests confirmed the supposed mechanism.
Synthesis, Structure, and Halo‐, Photo‐, and Thermochromism Properties of 5‐Azotriazolyl Salicylic Acid and Its CdII Complex
Authors: Lin Jiao‐Min , Yang Meng , Qiu Yan‐Xuan , Chen Wen‐Bin , Yan Hua , Gao Fei‐Xian , OuYang Zhen‐Jie , Dong Wen , Kuang Tong‐Chun 
Published: May 2013

AbstractA hydrated 5‐azotriazolyl salicylic acid of [(H3ATSA)]⋅2 H2O (1) and its CdII complex of [Cd2(H2ATSA)4]⋅13 H2O (2) have been synthesized and characterized by single‐crystal X‐ray diffraction analysis and a neutral trans‐Z‐enol form of H3ATSA and another anionic trans‐E‐enol H2ATSA− isomer have been found in 1 and 2, respectively. The yellow crystal of 2 can be transformed in situ into red crystals in NaOH solution. The diffuse reflectance and photoluminescent spectra for the crystal powder samples and the aqueous solutions of 1 and 2 have been investigated. The DFT and TDDFT calculations at B3LYP/6–31G* level for 1 and B3LYP/Lanl2dz level for 2 have been used to demonstrate the characteristic absorption spectra and the trans‐enol to cis‐keto photo‐ and thermoisomeric reaction for the ATSA3− anion. The onion cell imaging taken by confocal laser scanning microscope was observed with 1 and 2 as fluorescent labels.
Nafion‐Resin‐Modified Mesocellular Silica Foam Catalyst for 5‐Hydroxymethylfurfural Production from D‐Fructose
Authors: Huang Zhen , Pan Wenya , Zhou Haibo , Qin Feng , Xu Hualong , Shen Wei 
Published: May 2013

AbstractCatalytic dehydration of D‐fructose to 5‐hydroxymethylfurfural (HMF) was investigated over a series of Nafion‐modified mesocellular silica foam (MCF) materials. By using an impregnation method, Nafion resin was highly dispersed in the ultra‐large pores of the MCFs. Highly efficient and selective dehydration of D‐fructose to HMF was achieved in dimethyl sulfoxide solvent; an 89.3 % HMF yield with 95.0 % selectivity was obtained in the presence of the Nafion(15)/MCF catalyst. The effects of reaction temperature, reaction time, and solvent on the dehydration of D‐fructose were systematically investigated. The catalyst could be regenerated through an ion‐exchange method and a high yield was retained after being used five times. As a heterogeneous catalytic process, a possible reaction mechanism for the dehydration of D‐fructose over Nafion‐modified MCF catalysts was proposed.
Composite Poly(ethylene oxide) Electrolytes Plasticized by N‐Alkyl‐N‐butylpyrrolidinium Bis(trifluoromethanesulfonyl)imide for Lithium Batteries
Authors: Wetjen Morten , Navarra Maria Assunta , Panero Stefania , Passerini Stefano , Scrosati Bruno , Hassoun Jusef 
Published: May 2013

AbstractWe report a new class of quaternary polymer electrolyte membranes that comprise poly(ethylene oxide) (PEO), lithium trifluoromethanesulfonylimide (LiTFSI), N‐alkyl‐N‐butylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PyrA,4TFSI) as an ionic liquid, and a SiO2 filler. The results of differential scanning calorimetry indicate that the addition of SiO2 and different ionic liquids induces a decrease in the PEO melting enthalpy, which thereby increases the ionic conductivity and the Li transference number. The electrochemical stability is proved by using impedance spectroscopy and cyclic voltammetry. Galvanostatic cycling of Li/LiFePO4 cells, which comprise the quaternary polymer electrolytes, revealed their superior performance compared to conventional PEO‐Li salt electrolytes. In the course of this investigation, a synergistic effect of the combined ionic liquid‐ceramic filler modification could be proved at temperatures close to 50 °C.
High‐resolution prediction of leaf onset date in Japan in the 21st century under the IPCC A1B scenario
Authors: Hadano Mayumi , Nasahara Kenlo Nishida , Motohka Takeshi , Noda Hibiki Muraoka , Murakami Kazutaka , Hosaka Masahiro 
Published: May 2013

AbstractReports indicate that leaf onset (leaf flush) of deciduous trees in cool‐temperate ecosystems is occurring earlier in the spring in response to global warming. In this study, we created two types of phenology models, one driven only by warmth (spring warming [SW] model) and another driven by both warmth and winter chilling (parallel chill [PC] model), to predict such phenomena in the Japanese Islands at high spatial resolution (500 m). We calibrated these models using leaf onset dates derived from satellite data (Terra/MODIS) and in situ temperature data derived from a dense network of ground stations Automated Meteorological Data Acquisition System. We ran the model using future climate predictions created by the Japanese Meteorological Agency's MRI‐AGCM3.1S model. In comparison to the first decade of the 2000s, our results predict that the date of leaf onset in the 2030s will advance by an average of 12 days under the SW model and 7 days under the PC model throughout the study area. The date of onset in the 2090s will advance by 26 days under the SW model and by 15 days under the PC model. The greatest impact will occur on Hokkaido (the northernmost island) and in the central mountains.
Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer
Authors: Tan Tuan Zea , Miow Qing Hao , Huang Ruby Yun‐Ju , Wong Meng Kang , Ye Jieru , Lau Jieying Amelia , Wu Meng Chu , Bin Abdul Hadi Luqman Hakim , Soong Richie , Choolani Mahesh , Davidson Ben , Nesland Jahn M. , Wang Ling‐Zhi , Matsumura Noriomi , Mandai Masaki , Konishi Ikuo , Goh Boon‐Cher , Chang Jeffrey T. , Thiery Jean Paul , Mori Seiichi 
Published: May 2013

AbstractEpithelial ovarian cancer (EOC) is hallmarked by a high degree of heterogeneity. To address this heterogeneity, a classification scheme was developed based on gene expression patterns of 1538 tumours. Five, biologically distinct subgroups — Epi‐A, Epi‐B, Mes, Stem‐A and Stem‐B — exhibited significantly distinct clinicopathological characteristics, deregulated pathways and patient prognoses, and were validated using independent datasets. To identify subtype‐specific molecular targets, ovarian cancer cell lines representing these molecular subtypes were screened against a genome‐wide shRNA library. Focusing on the poor‐prognosis Stem‐A subtype, we found that two genes involved in tubulin processing, TUBGCP4 and NAT10, were essential for cell growth, an observation supported by a pathway analysis that also predicted involvement of microtubule‐related processes. Furthermore, we observed that Stem‐A cell lines were indeed more sensitive to inhibitors of tubulin polymerization, vincristine and vinorelbine, than the other subtypes. This subtyping offers new insights into the development of novel diagnostic and personalized treatment for EOC patients.