bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Combined α,α‐Dialkylprolinol Ether/Broensted Acid Promotes Mannich Reactions of Aldehydes with Unactivated Imines. An Entry to anti‐Configured Propargylic Amino Alcohols.
Authors: Gomez‐Bengoa Enrique , Jimenez Jacqueline , Lapuerta Irati , Mielgo Antonia , Oiarbide Mikel , Otazo Itziar , Velilla Irene , Vera Silvia , Palomo Claudio 
Published: March 2013

AbstractA series of amino alcohols (III) and (IX) is prepared with 80—98% diastereomeric excess using a hitherto not reported enamine‐mediated antiselective Mannich reaction of corresponding imines with aldehydes (II).
ChemInform Abstract: Organocatalytic Conjugate Addition of α‐Nitroacetates to β,γ‐Unsaturated α‐Keto Esters and Subsequent Decarboxylation: Synthesis of Optically Active δ‐Nitro‐α‐keto Esters.
Authors: Lu Rui‐jiong , Wei Wen‐tao , Wang Jin‐jia , Nie Shao‐zhen , Zhang Xue‐jing , Yan Ming 
Published: March 2013

AbstractPyrrolidine‐based thiourea‐tertiary amine PTU is used as an efficient organocatalyst for the title reaction.
ChemInform Abstract: Synthesis of Aromatic α‐Aminoesters: Palladium‐Catalyzed Long‐Range Arylation of Primary Csp3—H Bonds.
Authors: Aspin Sam , Goutierre Anne‐Sophie , Larini Paolo , Jazzar Rodolphe , Baudoin Olivier 
Published: March 2013

AbstractThe reaction with aryl bromides proceeds selectively at the terminal position of linear alkyl chains.
ChemInform Abstract: Ullmann Homocoupling Catalyzed by Gold Nanoparticles in Water and Ionic Liquid.
Authors: Monopoli Antonio , Cotugno Pietro , Palazzo Gerardo , Ditaranto Nicoletta , Mariano Bruno , Cioffi Nicola , Ciminale Francesco , Nacci Angelo 
Published: March 2013

AbstractThe gold nanoparticle catalyst is prepared in situ from gold(III) acetate with glucose as reducing agent.
ChemInform Abstract: Flow Synthesis of Arylboronic Esters Bearing Electrophilic Functional Groups and Space Integration with Suzuki—Miyaura Coupling without Intentionally Added Base.
Authors: Nagaki Aiichiro , Moriwaki Yuya , Yoshida Jun‐ichi 
Published: March 2013

AbstractThe synthesis of boronic esters (III) proceeds readily in a flow microreactor by a halogen‐lithium exchange reaction of aryl halides and a subsequent borylation of aryllithium intermediates (12 examples).
ChemInform Abstract: An Efficient Route to Polysubstituted Tetrahydronaphthols: Silver‐Catalyzed [4 + 2] Cyclization of 2‐Alkylbenzaldehydes and Alkenes.
Authors: Zhu Shifa , Liang Renxiao , Jiang Huanfeng , Wu Wanqing 
Published: March 2013

AbstractAn efficient protocol is developed for the diastereoselective synthesis of a broad spectrum of ring systems, which represent substructures of biologically active natural products.
ChemInform Abstract: Gold Vinylidene Complexes. Intermolecular C(sp3)—H Insertions and Cyclopropanations Pathway.
Authors: Hashmi A. Stephen K. , Wieteck Marcel , Braun Ingo , Rudolph Matthias , Rominger Frank 
Published: March 2013

AbstractCyclization of diyne (II) in the presence of gold complexes (Ia)/(Ib) results in formation of a highly reactive vinylidene intermediate which is treated with alkenes to yield a series of annulated ring systems containing a cyclobutane moiety.
ChemInform Abstract: Chemoselective Synthesis of Naphthylamides and Isoquinolinones via Rhodium‐Catalyzed Oxidative Dehydrogenative Annulation of Benzamides with Alkynes.
Authors: Shi Zhuangzhi , Tang Conghui , Jiao Ning 
Published: March 2013

AbstractDepending on the reaction conditions this method can be used to synthesize naphthalene derivatives (III) as well as benzo[h]isoquinoline derivatives (VI).
ChemInform Abstract: Synthesis of Indenes via Broensted Acid Catalyzed Cyclization of Diaryl‐ and Alkyl Aryl‐1,3‐dienes.
Authors: Eom Dahan , Park Sangjune , Park Youngchul , Ryu Taekyu , Lee Phil Ho 
Published: March 2013

AbstractThe title reaction allows mild and efficient access to a number of indenes.
ChemInform Abstract: Chiral Schiff Base Ligated Dioxomolybdenum (VI) Complexes and Their Asymmetric Catalytic Properties in the Epoxidation of Styrene.
Authors: Sui Yan , Liu Dongsheng , Hu Ronghua , Que Xiaobo 
Published: March 2013

AbstractComplexes of type (I) are synthesized and characterized.
ChemInform Abstract: Lewis‐Acid‐Promoted Arylation Reaction: Synthesis of Dihydrobenzofuran Derivatives from Aryltriazenes.
Authors: Zhao Guoqing , Wang Binjie , Yang Weijun , Ren Hongjun 
Published: March 2013

AbstractThe title reaction proceeds under mild conditions with good tolerance of a variety of functional groups.
ChemInform Abstract: Synthesis of Hexahydroindoles by Intramolecular C(sp3)—H Alkenylation: Application to the Synthesis of the Core of Aeruginosins.
Authors: Sofack‐Kreutzer Julien , Martin Nicolas , Renaudat Alice , Jazzar Rodolphe , Baudoin Olivier 
Published: March 2013

AbstractRegioselective intramolecular alkenylation of cycloalkenyl bromides offers a unique route to hexahydroindole derivatives.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of 1‐Aminoazoles with Aryl Chlorides: Application to the Synthesis of Unsymmetrical N,N‐Diaryl‐1‐aminoindoles.
Authors: Brachet Etienne , Messaoudi Samir , Peyrat Jean‐Francois , Brion Jean‐Daniel , Alami Mouad 
Published: March 2013

AbstractThis is a selective mono‐N‐arylation of 1‐aminoindoles to give compounds (III), which can undergo a second N‐arylation to yield compounds (IX).
ChemInform Abstract: Palladium‐Catalyzed Cyclization of β‐Bromo‐α,β‐unsaturated Ketones with Arylhydrazines Leading to 3‐Substituted 1‐Aryl‐1H‐pyrazoles.
Authors: Lee Hye Kyung , Cho Chan Sik 
Published: March 2013

AbstractThe title reaction provides a promising method for the synthesis of valuable heterocycles from readily available simple ketones.
ChemInform Abstract: Synthesis of New Pyrazolines and Their Biological Evaluation as Antimicrobial Agents.
Authors: Ben Hamadi Naoufel , Haouas Amel , Methamem Mahbouba , Msaddek Moncef 
Published: March 2013

AbstractNovel pyrazolines (III) and (V) are prepared via 1,3‐dipolar cycloaddition of diazo compounds to alkynes (I).
ChemInform Abstract: A General and Efficient Palladium‐Catalyzed Carbonylative Synthesis of 2‐Aryloxazolines and 2‐Aryloxazines from Aryl Bromides.
Authors: Wu Xiao‐Feng , Neumann Helfried , Neumann Stephan , Beller Matthias 
Published: March 2013

AbstractA wide range of aromatic and heteroaromatic bromides is applied.
ChemInform Abstract: 2,6‐Disubstituted Imidazo[2,1‐b][1,3,4]thiadiazoles: Search for Anticancer Agents.
Authors: Noolvi Malleshappa N. , Patel Harun M. , Kamboj Sarita , Kaur Amandeep , Mann Vikas 
Published: March 2013

AbstractA variety of novel title heterocycles (III) (34 examples) are synthesized and selected derivatives are screened for their cytotoxicity.
ChemInform Abstract: Enantioselective Construction of Sterically Hindered Tertiary α‐Aryl Ketones: A Catalytic Asymmetric Synthesis of Isoflavanones.
Authors: Carroll Michael P. , Mueller‐Bunz Helge , Guiry Patrick J. 
Published: March 2013

AbstractSubstrates (I) are prepared by arylation of β‐ketoesters with aryl lead triacetates.
ChemInform Abstract: Synthesis of 2‐Aryl‐3‐hydroxymethyl‐5,5‐difluoropiperidines.
Authors: Moens Matthias , Verniest Guido , De Schrijver Matthias , ten Holte Peter , Thuring Jan‐Willem , Deroose Frederik , De Kimpe Norbert 
Published: March 2013

AbstractTitle compounds, e.g (V), are prepared as potential building blocks in medicinal chemistry.
ChemInform Abstract: Domino Cyclocondensation of Arylaldehydes with 2‐Acetylpyridine.
Authors: Chang Meng‐Yang , Wu Ming‐Hao 
Published: March 2013

AbstractBase‐mediated reaction of benzaldehydes with 3 equivalents of 2‐acetylpyridine affords cyclohexane derivatives (III) (22 examples) in excellent regio‐ and stereoselectivity via a one‐pot domino Claisen—Schmidt condensation/Michael addition/double aldol reaction sequence.
ChemInform Abstract: A Simple and Expedient Synthesis of Functionalized Pyrido[2,3‐c] Coumarin Derivatives Using Molecular Iodine Catalyzed Three‐Component Reaction.
Authors: Khan Abu T. , Das Deb K. , Islam Kobirul , Das Pradipta 
Published: March 2013

AbstractOptimized conditions allow the preparation of the pharmaceutically important heterocyclic system in good to excellent yields.
ChemInform Abstract: Synthesis and in vitro and in vivo Anticancer Activity of Novel 3‐Methyl‐5H‐isoxazolo[5′,4′:5,6]pyrido[2,3‐b]indoles.
Authors: Rajanarendar E. , Reddy K. Govardhan , Ramakrishna S. , Reddy M. Nagi , Shireesha B. , Durgaiah G. , Reddy Y. N. 
Published: March 2013

AbstractThe in vivo and in vitro screening of the title compounds (IV) (8 examples) for their anticancer activities shows that compounds (IVb) and (IVd) exhibit potential anticancer activities as compared with the reference compound Cisplatin.
ChemInform Abstract: Convenient Synthesis of 2,4‐Disubstituted Pyrido[2,3‐d]pyrimidines via Regioselective Palladium‐Catalyzed Reactions.
Authors: Riadi Yassine , Massip Stephane , Leger Jean‐Michel , Jarry Christian , Lazar Said , Guillaumet Gerald 
Published: March 2013

AbstractA novel and efficient route for the synthesis of the rare title compounds (V) is reported by sequential coupling involving a regioselective chlorine discrimination.
ChemInform Abstract: Fe3O4 Nanoparticle‐Supported Copper(I): Magnetically Recoverable and Reusable Catalyst for the Synthesis of Quinazolinones and Bicyclic Pyrimidinones.
Authors: Yu Lin , Wang Min , Li Pinhua , Wang Lei 
Published: March 2013

AbstractThe developed catalyst exhibits excellent reactivity in the title synthesis and can be recycled over ten times in reactions without any obvious loss in its activity.
ChemInform Abstract: One‐Pot Three‐Component Synthesis of 1,4‐Bis[thiazolo[4,5‐d]pyrimidin‐7(6H)‐one]piperazine Derivatives.
Authors: Fang Zheng Dong , Wei Xian Hong 
Published: March 2013

AbstractThe domino process involves an aza‐Wittig reaction followed by heterocyclization in the presence of sodium ethoxide.
ChemInform Abstract: Novel 3‐Substituted‐1‐aryl‐5‐phenyl‐6‐anilinopyrazolo[3,4‐d]pyrimidin‐4‐ones: Docking, Synthesis and Pharmacological Evaluation as a Potential Antiinflammatory Agents.
Authors: Yewale Sandeep B. , Ganorkar Saurabh B. , Baheti Kamalkishor G. , Shelke Rupesh U. 
Published: March 2013

AbstractCompound (IIf) shows superior anti‐inflammatory activity in comparison with diclophenac sodium and comparable activity with celecoxib at a dose of 25mg/kg and its COX‐2 docking score is found to be better than the standard celecoxib.
ChemInform Abstract: AgNO3 Mediated C—N Bond Forming Reaction: Synthesis of 3‐Substituted Benzothiazines as Potential COX Inhibitors.
Authors: Rambabu D. , Murthy P. V. N. S. , Prasad K. R. S. , Kandale Ajit , Deora Girdhar Singh , Rao M. V. Basaveswara , Pal Manojit 
Published: March 2013

AbstractBased on the oxicam family of anti‐inflammatory agents, benzothiazines devoid of an enolic hydroxyl group are designed and synthesized.
ChemInform Abstract: Three Practical Approaches for the Synthesis of Novel 4,7‐Dihetarylpyrazolo[1,5‐a][1,3,5]triazines.
Authors: Insuasty Henry , Insuasty Braulio , Castro Edison , Quiroga Jairo , Abonia Rodrigo , Nogueras Manuel , Cobo Justo 
Published: March 2013

AbstractBest results are achieved by reaction of S,S‐diethyl thiocarbonates (I) with aminopyrazoles (II) under neat conditions and microwave irradiation.
ChemInform Abstract: Palladium‐Catalyzed Double N‐Arylation to Synthesize Multisubstituted Dibenzoazepine Derivatives.
Authors: Zhang Xiaoyun , Yang Yuan , Liang Yun 
Published: March 2013

AbstractVarious bis(2‐bromophenyl)ethenes are treated with primary aromatic and aliphatic amines to produce medicinally interesting functionalized systems.
ChemInform Abstract: Iridium‐Catalyzed Enantioselective Allylation of Sodium 2‐Aminobenzenethiolate: An Access to Chiral Benzo‐Fused N,S‐Heterocycles.
Authors: Gao Ning , Guo Xin‐Wen , Zheng Sheng‐Cai , Yang Wei‐Kang , Zhao Xiao‐Ming 
Published: March 2013

AbstractAllylation of sodium aminobenzenethiolates (I) with a range of methyl allyl carbonates predominantly give branched products with high regio‐ and enantioselectivities.
ChemInform Abstract: One‐Pot C—N/C—C Cross‐Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization.
Authors: Grob Jonathan E. , Dechantsreiter Michael A. , Tichkule Ritesh B. , Connolly Michael K. , Honda Ayako , Tomlinson Ronald C. , Hamann Lawrence G. 
Published: March 2013

AbstractIn the presence of PAP and K3PO4 or LiHMDS, boronyl arenes undergo convenient amination to afford a wide range of arylamines.
ChemInform Abstract: Tinospinosides D, E, and Tinospin E, Further Clerodane Diterpenoids from Tinospora sagittata
Authors: Huang Chao , Li Wei , Ma Fenghua , Li Qin , Asada Yoshihisa , Koike Kazuo 
Published: March 2013

Abstractisolation, structure determination and evaluation of the inhibitory activity of the novel tinospinosides D (I), E (IIa), and tinospin E (IIb) on nitric oxide production in lipopolysaccharide and interferon‐γ activated J774.1 macrophage‐like cells
ChemInform Abstract: Minor Withanolides of Physalis longifolia: Structure and Cytotoxicity.
Authors: Zhang Huaping , Motiwala Hashim , Samadi Abbas , Day Victor , Aube Jeffrey , Cohen Mark , Kindscher Kelly , Gollapudi Rao , Timmermann Barbara 
Published: March 2013

AbstractTwo new minor withanolides, i.e.
ChemInform Abstract: Diarylheptanoid Glycosides from Tacca plantaginea and Their Effects on NF‐ϰB Activation and PPAR Transcriptional Activity.
Authors: Kim Young Ho , et al. et al. 
Published: March 2013

Abstractisolation, structure determination and biological activity of two new diarylheptanoid glycosides, plantagineosides A (I) and B (II), an unusual cyclic diarylheptanoid glycoside, plantagineoside C (II), and three known compounds
ChemInform Abstract: Synthesis and Characterization of Thiazolo‐ and Thiazinomorphinans and Their Intermediate Products as Novel Opioid‐Active Derivatives.
Authors: Sipos Attila , Follia Valeria , Berenyi Sandor , Antus Sandor , Schmidhammer Helmut , Spetea Mariana 
Published: March 2013

AbstractThe two most potent derivatives (V) and (XI) are further examinated in ligand‐stimulated [35S]GTPγS assays.
ChemInform Abstract: First Total Synthesis of Prasinic Acid and Its Anticancer Activity.
Authors: Chakor Narayan , Patil Ganesh , Writer Diana , Periyasamy Giridharan , Sharma Rajiv , Roychowdhury Abhijit , Mishra Prabhu Dutt 
Published: March 2013

AbstractA ten‐step synthesis of prasinic acid (I) starting from readily available and cheap materials is presented.
Spectroscopic Studies on Nicotine and Nornicotine in the UV Region
Authors: Clayton Peter M. , Vas Carl A. , Bui Tam T.T. , Drake Alex F. , McAdam Kevin 
Published: March 2013

ABSTRACTThe UV absorption and electronic circular dichroism (ECD) spectra of (R)‐ and (S)‐nicotine and (S)‐nornicotine in aqueous solution were measured to a significantly lower wavelength range than previously reported, allowing the identification of four previously unobserved electronic transitions. The ECD spectra of the two enantiomers of nicotine were equal in magnitude and opposite in sign, while the UV absorption spectra were coincidental. In line with previous observations, (S)‐nicotine exhibited a negative cotton effect centered on 263 nm with vibronic structure (π–π1* transition) and a broad, positive ECD signal at around 240 nm associated with the n–π1* transition. As expected this band disappeared when the pyridyl aromatic moiety was protonated. Four further electronic transitions are reported between 215 and 180 nm; it is proposed the negative maxima around 206 nm is either an n–σ* transition or a charge transfer band resulting from the movement of charge from the pyrrolidyl N lone pair to the pyridyl π* orbital. The pyridyl π–π2* transition may be contained within the negative ECD signal envelope at around 200 nm. Another negative maximum at 188 nm is thought to be the pyridyl π–π3* transition, while the lowest wavelength end‐absorption and positive ECD may be associated with the π–π4* transition. The UV absorption spectra of (S)‐nornicotine was similar to that of (S)‐nicotine in the range 280–220 nm and acidification of the aqueous solution enhanced the absorption. The ECD signals of (S)‐nornicotine were considerably less intense compared to (S)‐nicotine and declined further on acidification; in the far UV region the ECD spectra diverge considerably. Chirality 25:288–293, 2013. © 2013 Wiley Periodicals, Inc.
Biosynthesis of Silver Nanoparticles by Septoria apii and Trichoderma koningii
Authors: Huang Weidong , Yan Jingjing , Wang Yue , Hou Cailing , Dai Tianchun , Wang Zhimin 
Published: March 2013

AbstractSilver nanoparticles were synthesized by Septoria apii and Trichoderma koningii for the first time and characterized systematically.
Calcined Mg‐Al Layered Double Hydroxide as a Heterogeneous Catalyst for the Synthesis of Urea Derivatives from Amines and CO2
Authors: Zhang Ran , Hua Li , Guo Li , Song Baoning , Chen Jizhong , Hou Zhenshan 
Published: March 2013

AbstractThe calcined Mg‐Al layered double hydroxides (LDHs) with a Mg/Al molar ratio of 3:1 were synthesized and characterized thoroughly by X‐ray diffraction (XRD), temperature‐programmed desorption (TPD) of CO2, and thermogravimetric analysis (TGA). Thus the calcined Mg‐Al LDHs were used as catalyst for the catalytic synthesis of disubstituted ureas from amines and CO2. The effects of reaction time, reaction temperature, pressure, solvent and calcined temperature on activity have been investigated. The results indicated that aliphatic amines, cyclohexylamine and benzylamine can be converted to the corresponding ureas selectively over the calcined Mg‐Al LDHs catalysts with N‐methyl‐2‐pyrrolidone (NMP) as solvent without using any dehydrating regent. The catalyst can be recycled several times with only slight loss of activity.
Aza‐Belluš‐Claisen Rearrangement‐Enabled Synthesis of Racemic Tapentadol and Its Stereoisomers
Authors: Bai Donghu , Huang Sha‐Hua , Lin Zuming , Yang Lin , Dai Junzeng , Huang Meng‐Yuan , Jia Xueshun , Hong Ran 
Published: March 2013

AbstractA concise synthesis of racemic Tapentadol and its stereoisomers was presented. The key step was a TiCl4·THF2‐catalzyed aza‐Belluš‐Claisen rearrangement to create two vicinal tertiary carbon stereogenic centers. The subsequent reduction of amide and hydrogenation of alkene delivered Tapentadol and its stereoisomers. The current approach offers a practical synthetic route to access this class of pharmaceutically significant molecules.
Frequency of Severe Valvular Disease Caused by Mediastinal Radiation Among Patients Undergoing Valve Surgery in a Community‐Based, Regional Academic Medical Center
Authors: Copeland Kevin A. , Hosmane Vinay R. , Jurkovitz Claudine , Kolm Paul , Bowen Jim , DiSabatino Angela , Banbury Michael K. , Strasser Jon F. , Weintraub William S. , Doorey Andrew J. 
Published: March 2013

AbstractBackgroundOur goal was to define the prevalence of radiation‐induced valvular heart (RIVD) disease among patients undergoing cardiac valve surgery in a community‐based, regional academic medical center. Mediastinal radiation is a treatment modality for various hematologic and solid malignancies; however, long‐term cardiac complications, including radiation‐induced valvular heart disease, can occur years after the radiation treatments.HypothesisMediastinal radiation exposure is an independent risk factor for valvular heart disease often necessitating valve replacement in patients without other risk factors for valve disease.MethodsBetween January 1, 1998 and September 1, 2007, we retrospectively analyzed our institution's cardiac surgical database over a 10 year period and identified 189 consecutive patients ≤ 50 years of age who underwent valve surgery. Using case‐control matching, we assessed the prevalence of mediastinal radiation among these young patients with valve disease necessitating surgery and to their matched controls from all patients admitted to the hospital.ResultsNine individuals (4.8%) were identified as having received previous mediastinal radiation, significantly increased from controls (p<0.0001), and 8 of whom had surgical or pathologic findings consistent with radiation damage. Compared with a matched case‐control population, individuals who had severe valve disease and underwent valve replacement had a markedly increased prevalence of prior mediastinal radiation therapy.ConclusionsIn conclusion, cardiologists must remain aware of the potential long term valvular complications in patients treated with mediastinal radiation. Increased surveillance for RIVD may be considered in the decades following radiation therapy.
Cost‐Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Patients With Atrial Fibrillation—A Real Patient Data Analysis in a Hong Kong Teaching Hospital
Authors: Chang Andy M. , Ho Jason C. S. , Yan Bryan P. , Yu Cheuk Man , Lam Yat Yin , Lee Vivian W. Y. 
Published: March 2013

AbstractBackgroundTo compare the management cost and cost‐effectiveness of dabigatran with warfarin in patients with nonvalvular atrial fibrillation (AF) from the hospital's and patients' perspectives.HypothesisDabigatran is more cost‐effective than warfarin for stroke prevention of AF in Hong Kong.MethodsThe analysis was performed in conjunction with a drug utilization evaluation of dabigatran study in a teaching hospital in Hong Kong. The study recruited 244 patients who received either dabigatran or warfarin for stroke prevention of AF. A cost‐effectiveness analysis was performed and was expressed as an incremental cost‐effectiveness ratio (ICER) in averting a cardiac event or a bleeding event. A sensitivity analysis was used on all relevant variables to test the robustness.ResultsFrom the hospital's perspective, the dabigatran group had a lower total cost of management than that of the warfarin group (median: US$421 vs US$1306, P < 0.001) (US$1 = HK$7.75) and was dominant over warfarin. From the patients' perspective, the total cost of management in the dabigatran group was higher than that in warfarin group (median: US$1751 vs US$70, P < 0.001), and the ICER in preventing a cardiac or bleeding event of dabigatran vs warfarin was estimated at US$68 333 and US$20 500, respectively. If dabigatran was subsidized by the hospital, a higher cost would be incurred by the hospital (median: US$1679 vs US$1306, ICER (cardiac and bleeding events): US$15 163 and US$4549, respectively).ConclusionsThe study favored dabigatran for stroke prophylaxis in patients with nonvalvular AF in Hong Kong under the current hospital's perspective and provided a reference for further comparisons under patient and subsidization perspectives.