bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing Cefiderocol Dosing Through Population Pharmacokinetic/Pharmacodynamic Simulation: An Assessment of Drug Cost Reductions
Authors: Oda Kazutaka , Jono Hirofumi , Saito Hideyuki 
Published: July 2024

Background:
Cefiderocol is a siderophore cephalosporin antibiotic with bactericidal activity against carbapenem-resistant Enterobacterales. However, an efficient dosing strategy is yet to be developed. This study aimed to evaluate efficient lower-dose regimens and estimate potential drug cost reductions.

Methods:
This simulation study used a virtual population of 10,000 resampled individuals based on a reported population pharmacokinetic model. The target index for maximal bactericidal activity was the time for the unbound cefiderocol concentration to be above the minimum inhibitory concentration (TAM_unbound) of 100%, which was determined using a minimum inhibitory concentration distribution or specific value.

Results:
The probability of achieving 100% TAM_unbound with the standard, low- (reduced by 1 g or one dose), and extended low- (reduced by 2 g or 2 doses) dose regimens was nearly 100%. The lowest probability of achieving 100% TAM_unbound with the extended low-dose regimen at a creatinine clearance range of 90–120 mL/min was 86.4%. The probability of achieving TAM_unbound of 100% was more than 90% for MIC of ≤0.5 mcg/mL with the extended low-dosing regimen. Furthermore, using an efficient dosing regimen reduced the medical costs over a 10-day treatment period for 10 patients, from $122,826.50 to $62,665.69 $ and ¥12,598,187 $ to ¥5,451,173 in the United States and Japan, respectively.

ConclusionsS
A lower dosing regimen for cefiderocol could result in substantial reductions in drug costs while still achieving 100% TAM_unbound.
A Technique of Multiple Corneal Allogeneic Ring Segments Prepared From a Single Corneal Graft: A Case Series
Authors: Mechleb Nicole , Gatinel Damien , Saad Alain 
Published: July 2024

Purpose:
To describe a novel technique for preparing multiple corneal allogeneic ring segments (CAIRS) from a single corneal graft using femtosecond laser technology.

Methods:
This is a case series of 10 eyes from 10 patients with keratoconus who underwent FS-assisted CAIRS implantation using corneas from 4 donors at the Hospital Foundation Adolphe de Rothschild-Noémie de Rothschild institute. A preoperative and postoperative examination was performed at 1 day, 1 week, and 1 month. Anterior segment OCT and corneal tomography with aberrometric and pachymetric analyses were performed at each visit. Visual, refractive, and topographic parameters were extracted. The thickness and width of implanted CAIRS were analyzed.

Results:
Patients were classified according to keratoconus severity: group A (maximal keratometry Kmax <75D) and group B (Kmax >75D). At 1 month postoperatively, both groups A and B showed a significant decrease in mean keratometry by 4.78 ± 1.57D and 12.87 ± 4.62D, respectively. Total and higher order aberrations decreased by 5.66 ± 4.55 and 0.65 ± 1.54 in group A and by 9.45 ± 9.15 and 0.49 ± 1.39 in group B, respectively. The corrected distance visual acuity improved by 4.8 ± 1.7 lines in group A. Visual improvement was not significant in group B. One eye in group B exhibited acute rejection and required explantation.

Conclusions:
FS-assisted multiple CAIRS implantation using a single corneal graft maximizes the utilization of viable corneal tissue. CAIRS implantation is an effective and biocompatible therapeutic alternative, particularly in cases of moderate to advanced keratoconus with Kmax <75D.
Risk Factors for Acute-Level Hospital Course in Pediatric Craniofacial Fractures
Authors: Perez-Otero Sofia , Cassidy Michael F. , Morrison Kerry A. , Brydges Hilliard T. , Tran David , Muller John , Flores Roberto L. , Ceradini Daniel J. 
Published: July 2024

Purpose:
The pediatric craniofacial trauma literature is limited to single institutions or short study periods. Herein, this study analyzes a national database over 10 years to delineate the epidemiology of pediatric craniofacial fractures and to identify risk factors for acute-level hospital course in the largest series to date.

Methods:
Utilizing the National Trauma Data Bank, pediatric craniofacial fractures admitted between 2010 and 2019 were identified. Descriptive analyses and multivariable regression were performed to identify risk factors for acute-level hospital course.

Results:
A total of 155,136 pediatric craniofacial fracture cases were reviewed, including cranial vault (49.0%), nasal (22.4%), midface (21.0%), mandibular (20.2%), and orbital floor fractures (13.7%). Midface and orbital floor fractures occurred commonly as multicraniofacial fractures. Cranial vault fractures were the most common among all age groups, but frequency declined with age. In contrast, facial fractures increased with age. Despite the inherent complexity of multicraniofacial trauma, isolated fractures remained a concern for acute-level hospital course.
Cranial vault and midface fractures had an increased risk of intracranial injury and intensive care unit admission (P<0.001). Mandibular and midface fractures had an increased risk for cervical spine fracture and tracheostomy (P<0.001). Patient and injury-specific risk factors among the fractures with the strongest association for each outcome-cranial vault and mandible-were identified.

Conclusions:
The inherent limitations of prior studies—geographical biases, small cohorts, and short-term study periods—were addressed. Describing the independent contribution of each craniofacial fracture to the risk of acute-level hospital course outcomes can be employed to better optimize risk stratification, counseling, and management.
Dynamic Transcriptome Analysis of SFRP Family in Guided Bone Regeneration With Occlusive Periosteum in Swine Model
Authors: Chen Xiaoxue , Yu Baofu , Wang Zi , Zhou Qimin , Wu Qifeng , He Jinguang , Dai Chuanchang , Li Qingfeng , Wei Jiao 
Published: July 2024

Background:
A variety of congenital or acquired conditions can cause craniomaxillofacial bone defects, resulting in a heavy financial burden and psychological stress. Guided bone self-generation with periosteum-preserved has great potential for reconstructing large bone defects.

Methods:
A swine model of guided bone regeneration with occlusive periosteum was established, the rib segment was removed, and the periosteum was sutured to form a closed regeneration chamber. Hematoxylin and eosin staining, Masson’s staining, and Safranine O-Fast Green staining were done. Nine-time points were chosen for collecting the periosteum and regenerated bone tissue for gene sequencing. The expression level of each secreted frizzled-related protein (SFRP) member and the correlations among them were analyzed.

Results:
The process of bone regeneration is almost complete 1 month after surgery, and up to 1 week after surgery is an important interval for initiating the process. The expression of each SFRP family member fluctuated greatly. The highest expression level of all members ranged from 3 days to 3 months after surgery. The expression level of SFRP2 was the highest, and the difference between 2 groups was the largest. Secreted frizzled-related protein 2 and SFRP4 showed a notable positive correlation between the control and model groups. Secreted frizzled-related protein 1, SFRP2, and SFRP4 had a significant spike in fold change at 1 month postoperatively. Secreted frizzled-related protein 1 and SFRP2 had the strongest correlation.

Conclusions:
This study revealed the dynamic expression of the SFRP family in guided bone regeneration with occlusive periosteum in a swine model, providing a possibility to advance the clinical application of bone defect repair.
Feedback cooling a levitated nanoparticle's libration to below 100 phonons
Authors: Gao Jialiang , van der Laan Fons , Zielińska Joanna A. , Militaru Andrei , Novotny Lukas , Frimmer Martin 
Published: July 2024

Macroscopic rotors are interesting model systems to test quantum theory and for quantum sensing. A promising approach for bringing these systems to the quantum regime is to combine sensitive detection with feedback cooling to reduce the thermal occupation of the mechanics. Here, we implement a backward-scattering scheme to efficiently detect all three libration modes of an optically levitated nanoparticle. We demonstrate parametric feedback cooling of all three libration degrees of freedom to below 16 mK, with one of the modes reaching the temperature of 1.3 mK, corresponding to a mean phonon number of 84. Finally, we characterize the backward-scattering scheme by determining its measurement efficiency to be 0.5%.

Published by the American Physical Society
2024
Implementing organizational ambidexterity using the balanced scorecard in Puebla City’s hotel industry, Mexico
Authors: Lastre Sierra Hassir , Ruiz Molina Antonio , Barrón Villaverde Diana 
Published: July 2024

PurposeThis paper investigates the effectiveness of the Ambidextrous Scorecard (ASC) in facilitating the integration of organizational ambidexterity in four-star Puebla City hotels for managing exploitation and exploration activities. It proposes an integrated approach to ambidexterity and introduces the ASC as a tool explicitly targeting hotels’ challenges and opportunities.Design/methodology/approachThe study analyzes survey data from 41 hotels (85.42% response rate). Our methodology involves a literature review, the Delphi technique for questionnaire validation, and data collection through Google Forms. Statistical tests confirm the reliability and validity of the approach for assessing the effective integration of exploitation and exploration activities.FindingsThe paper highlights how the ASC promotes an integrated approach to managing both activities. By incorporating exploitation activities (cost reduction, strategic alliances), and facilitating exploration activities (process innovation, new market attraction), the ASC empowers hotels to streamline operations, develop novel offerings, and achieve enhanced operational efficiency and innovation.Research limitations/implicationsWe acknowledge limitations due to its specific focus on the hotel industry in Puebla City, suggesting that the results may not be universally applicable. We recommended that further investigation be conducted into the application of the Ambidextrous Scorecard (ASC) across different sectors and regions to enhance understanding of organizational ambidexterity. Exploring the impact of integrating exploitation and exploration activities across corporate areas could offer valuable insights for implementing the ASC in diverse business settings.Practical implicationsThe paper indicates that hotels can achieve ambidexterity by integrating exploitation and exploration activities using the Balanced Scorecard. This approach enhances competitiveness, allowing hotels to anticipate and respond to market trends quickly. It highlights the significance of considering ambidexterity across all organizational areas to ensure sustained adaptability and performance in dynamic environments.Originality/valueThis paper introduces the concept of integrated ambidexterity and the ASC as a novel tool for managing the balance between innovation and efficiency. The ASC transcends the hotel industry, potentially benefiting various service sectors by facilitating a more integrated approach to organizational performance.
Preferred knowledge formats in mobile learning in Namibian public universities: a students’ perspective
Authors: Kaisara Godwin , Bwalya Kelvin Joseph 
Published: July 2024

Purpose
The aim of this study is to identify the various knowledge formats suitable for mobile learning in Namibian public universities.

Design/methodology/approach
Taking a qualitative design, data were collected through focus group interviews of students in two public universities in Namibia.

Findings
Results suggest that students consume knowledge in various formats, with videos the most preferred format. Furthermore, the results demonstrate that students’ preferences are shaped by various factors such as costs and quantity of information.

Research limitations/implications
The study was limited to two public Namibian universities. This limited scope, as well as its qualitative nature, means that findings cannot be arbitrarily generalized to other contexts but cardinal as a source of insight in contextually similar environments.

Practical implications
The findings reveal that teachers should be cognizant of the preferred knowledge formats for mobile learning to achieve its full potential in terms of effective teaching and learning. Therefore, teachers should package learning information for mobile learning in line with learners’ characteristics and preferences.

Originality/value
There is scant information on knowledge formats suitable for mobile learning. Consequently, this study contributes to the nascent body of knowledge on this important issue. Furthermore, although mobile learning uptake is on the ascendancy in Africa, to the best of our knowledge, no study of this nature has been undertaken in this context thereby leaving knowledge gaps for designers, researchers and practitioners in mobile learning.
Strategic crises management in Finland: government responses to COVID-19 pandemic
Authors: Johanson Jan-Erik , Pekkola Elias , Stenvall Jari , Rannisto Pasi-Heikki , Leponiemi Ulriika 
Published: July 2024

PurposeThis article examines the strategy formation in the Finnish government’s pandemic management during the COVID-19 pandemic, addressing a research gap by exploring the possibilities for strategy formation in guiding government policy formation.Design/methodology/approachUtilizing perspective of strategic planning and emergent strategies influenced by the authorizing environment, the article emphasizes the importance of strategy development in government. The management of COVID-19 pandemic serves as a case study for investigating public strategies in policy formation, underscoring the significance of the authorizing environment in integrating predefined strategic plans with emergent strategic avenues.FindingsThe management of pandemics has led to changes in legislation and modes of government decision-making, resulting in learnings for coordinating subnational governments and allocation of resources. The government actions evolved from extracting components from predefined strategic plans and drawing on the experiences of other countries. The emergent properties emerged from amalgamating these elements into an umbrella strategy with a variety of new responses.Research limitations/implicationsThe examination focuses on the view from the nexus of government. Although, informed by the subnational developments and stakeholder responses, the study adopts a bird’s eye view on the COVID-19 management.Practical implicationsThe examination raises needs for legislative changes, improvement of cross-sectoral coordination within central government and improvement for the decision-making capability within subnational government.Originality/valueBy focusing on the Finnish government’s measures in pandemic management, this article contributes to the discourse on pandemic management. The findings provide insights for strategic crisis management in the public sector.
Competition intensity is linked to the co‐occurrence status and height differences of plant species found growing together in an old‐field community
Authors: Gridzak Riley , Lavender Thomas Michael , Aarssen Lonnie W. , Schamp Brandon S. 
Published: July 2024

Abstract

Experimental evidence suggests that larger plant species generally have a competitive advantage and thus should dominate communities where competition for limiting resources (i.e. water, soil nutrients, light, space and/or mutualists) is intense. Additionally, researchers have postulated that competition can generate negative co‐occurrence patterns. However, neither expectation is strongly supported by empirical evidence.

In a relatively undisturbed old‐field plant community, we explored the interdependency of these expectations by examining pairwise species co‐occurrences, and pairwise species maximum height differences (measured here as the maximum potential height of the species), and by estimating competition intensity for sample plots using field transplants grown with and without neighbours. Specifically, we tested whether maximum species height differences were greater for negatively co‐occurring species pairs than for positively co‐occurring pairs found growing together. We also tested whether the maximum species height differences and co‐occurrence status of species pairs were associated with the average competitive environment they tended to be found growing in.

Negatively co‐occurring species pairs found growing together differed more in maximum height than in positively co‐occurring species pairs that were more similar in maximum height. Additionally, species maximum height differences between negatively co‐occurring species pairs where higher in less competitively intense plots, whereas species maximum heights were more similar between positively co‐occurring species pairs found growing together in less competitively intense plots.

Synthesis. Our results suggest an association between estimates of competition intensity generated using transplant experiments and co‐occurrence patterns. These findings contribute to our understanding of the association between size‐mediated competition and spatial organization in plant communities and provide a framework for future research in this area.
Innovate, conserve, grow: A comprehensive analysis of technological innovation, energy utilization, and carbon emission in BRICS
Authors: Zhang Meng , Imran Muhammad , Juanatas Ronaldo A. 
Published: July 2024

AbstractThe aim of this study was to embark on a transformative exploration of the interplay between technological innovation, renewable energy, economic development, and carbon emissions in BRICS nations, unveiling novel insights that redefine sustainability paradigms and contribute to global environmental policymaking. This comprehensive study spans the years 1990–2022, meticulously examining the dynamics of economic indicators, energy consumption, renewable energy generation, and technological progress. The dataset's non‐normal distribution prompts the use of moment quantile regression, providing nuanced insights with consideration for diverse slopes and cross‐sectional dependencies. Validation through the “Dumitrescu‐Hurlin panel Causality Test” refines the findings, revealing the diminishing impact of technological innovation across quantiles. The study illuminates a compelling connection: heightened technological innovation correlates strongly with reduced carbon emissions, particularly evident at lower quantiles. This aligns seamlessly with existing research, emphasizing technology's transformative potential for sustainability. Conversely, a concerning positive association emerges between energy utilization and carbon emissions, highlighting the persistent environmental challenge posed by escalating energy use. Urgent strategic interventions are underscored to address the ecological consequences associated with rising energy consumption. The intricate relationship between renewable electricity production and carbon emissions unfolds, emphasizing renewables' pivotal role in mitigating environmental impact. This aligns with ongoing discussions regarding their indispensable contribution to sustainable development. The study underscores the strategic importance of prioritizing renewable power production in environmental sustainability initiatives. However, a disconcerting positive association surfaces between economic development and carbon emissions across all quantiles, revealing the environmental costs accompanying economic growth in BRICS nations. As economic development advances, carbon emissions escalate, presenting substantial sustainability challenges and emphasizing the imperative to balance progress with environmental conservation efforts. This contribution enriches the ongoing discourse on fostering sustainability within the BRICS nations and beyond, marking a significant stride toward a more environmentally conscious future.
CEO Restricted Stock, Incentives, and Corporate Innovations*
Authors: Boli Yi , Oh Jong‐Min 
Published: July 2024

AbstractWe study the relation between CEO restricted stock, CEO incentives, and firm innovation. We first show that restricted stock is negatively associated with R&D investment. We also show that CEO restricted stock is positively related to the number of patents granted and citations received. However, further investigation shows that CEO restricted stock has a positive relation with firm exploitation but a negative relation with firm exploration and breakthrough innovation. The results suggest that restricted stock appears to incentivize CEOs to make efficient R&D investments and produce more innovative outputs in general, but only through exploitation rather than exploration and breakthrough innovations.
EATING LIKE THE ELITE AT NEO‐PALATIAL KNOSSOS
Authors: Nafplioti Argyro 
Published: July 2024

SummaryDiachronic research of social status differences in diet reveals a dynamic interplay of cultural, economic, and technological forces that have shaped the food choices of individuals across the past centuries. In this paper we focus on food and related practices at Palatial Knossos on Crete in the mid‐second millennium BC and review palaeodietary stable carbon and nitrogen isotope (δ13C and δ15N) data from two cemeteries to explore evidence for embodied social variation during the site’s uncontested heyday in the Neo‐palatial Period (c.1700 to 1500 BC). We show that analysis by sex and tomb suggests no significant social differentiation in access to food resources. Instead, temporal trends reveal increased availability of animal protein during the Neo‐palatial period, aligning with Knossos' political and economic supremacy. We argue that the equitable living circumstances at Knossos during the Neo‐palatial period may have contributed to the absence of factional competition and social unrest, potentially explaining the site's continuity into Post‐palatial times despite widespread destructions elsewhere on Crete. Overall, the findings shed light on the complex interplay between diet, social structure, and historical context at Neo‐palatial Knossos.
Dynamic changes in mRNA nucleocytoplasmic localization in the nitrate response of Arabidopsis roots
Authors: Fonseca Alejandro , Riveras Eleodoro , Moyano Tomás C. , Alvarez José M. , Rosa Stefanie , Gutiérrez Rodrigo A. 
Published: July 2024

AbstractNitrate is a nutrient and signal that regulates gene expression. The nitrate response has been extensively characterized at the organism, organ, and cell‐type‐specific levels, but intracellular mRNA dynamics remain unexplored. To characterize nuclear and cytoplasmic transcriptome dynamics in response to nitrate, we performed a time‐course expression analysis after nitrate treatment in isolated nuclei, cytoplasm, and whole roots. We identified 402 differentially localized transcripts (DLTs) in response to nitrate treatment. Induced DLT genes showed rapid and transient recruitment of the RNA polymerase II, together with an increase in the mRNA turnover rates. DLTs code for genes involved in metabolic processes, localization, and response to stimulus indicating DLTs include genes with relevant functions for the nitrate response that have not been previously identified. Using single‐molecule RNA FISH, we observed early nuclear accumulation of the NITRATE REDUCTASE 1 (NIA1) transcripts in their transcription sites. We found that transcription of NIA1, a gene showing delayed cytoplasmic accumulation, is rapidly and transiently activated; however, its transcripts become unstable when they reach the cytoplasm. Our study reveals the dynamic localization of mRNAs between the nucleus and cytoplasm as an emerging feature in the temporal control of gene expression in response to nitrate treatment in Arabidopsis roots.