bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). I. Drugs in preclinical and early clinical development
Authors: Bialer Meir , Johannessen Svein I. , Koepp Matthias J. , Perucca Emilio , Perucca Piero , Tomson Torbjörn , White H. Steve 
Published: July 2024

AbstractFor >30 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided a forum for the discussion of advances in the development of new therapies for seizures and epilepsy. The EILAT XVII conference took place in Madrid, Spain, on May 5–8, 2024. Participants included basic scientists and clinical investigators from industry and academia, other health care professionals, and representatives from lay organizations. We summarize in this article information on treatments in preclinical and in early clinical development discussed at the conference. These include AMT‐260, a gene therapy designed to downregulate the expression of Glu2K subunits of kainate receptors, in development for the treatment of drug‐resistant seizures associated with mesial temporal sclerosis; BHV‐7000, a selective activator of heteromeric Kv7.2/7.3 potassium channels, in development for the treatment of focal epilepsy; ETX101, a recombinant adeno‐associated virus serotype 9 designed to increase NaV1.1 channel density in inhibitory γ‐aminobutyric acidergic (GABAergic) neurons, in development for the treatment of SCN1A‐positive Dravet syndrome; GAO‐3‐02, a compound structurally related to synaptamide, which exerts antiseizure activity at least in part through an action on cannabinoid type 2 receptors; LRP‐661, a structural analogue of cannabidiol, in development for the treatment of seizures associated with Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex; OV329, a selective inactivator of GABA aminotransferase, in development for the treatment of drug‐resistant seizures; PRAX‐628, a functionally selective potent sodium channel modulator with preference for the hyperexcitable state of sodium channels, in development for the treatment of focal seizures; RAP‐219, a selective negative allosteric modulator of transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor regulatory protein γ‐8, in development for the treatment of focal seizures; and rozanolixizumab, a humanized anti‐neonatal Fc receptor monoclonal antibody, in development for the treatment of LGI1 autoimmune encephalitis. Treatments in more advanced development are summarized in Part II of this report.
Melanin accumulation in acanthotic seborrheic keratosis: Reduced proliferation and early differentiation of keratinocytes and increased number of melanocytes
Authors: Ueno Mizuki , Gabe Yu , Tobiishi Megumi , Komiya Aya , Yuki Takuo , Kawabata Keigo , Takahashi Yoshito , Suzuki Tamio 
Published: July 2024

AbstractSeborrheic keratosis (SK) is a common benign tumour, often associated with hyperpigmentation. To investigate the mechanism of melanin accumulation in SK, we have conducted comprehensive gene expression and histological analyses. We obtained five pairs of skin samples, including non‐lesional and SK samples, from the backs of three male Japanese participants aged 40–59 years. To examine melanocytes and keratinocytes in SK, three pairs of skin samples were separated by laser capture microdissection into the basal layer and the other layer in the epidermis. We performed a comprehensive gene expression analysis to identify differentially expressed genes between non‐lesional and SK skin, followed by gene ontology and pathway analysis. We found abnormal morphogenesis and cell proliferation in the basal layer, along with increased immune response and impaired cell differentiation and metabolism in the other layer of SK. We focused on cell proliferation and differentiation, as these are directly associated with melanin accumulation. Immunohistochemical analyses of Ki67, keratin 10, and keratin 14 demonstrated the decreases in the proliferation and early differentiation of the epidermis. Contrarily, no significant changes were observed in terminal differentiation markers, filaggrin and loricrin. Although the number of melanocytes was higher in SK than in non‐lesional skin, melanogenic activity showed no difference. These results indicated that melanin accumulation in SK is caused by delayed melanin excretion due to reduced turnover around the basal and spinous layers of the epidermis and melanin production due to an increased number of melanocytes. Our findings provide new insights for therapeutic approaches in SK.
Access denied: Reducing pediatric firearm mortality with smart gun technology
Authors: Mihailides Kary E. 
Published: July 2024

AbstractIn 2020, firearm‐related injuries became the leading cause of death in American children. Ensuring the safe storage of household firearms is one way to reduce those deaths. Since the 1990s, states have sought to accomplish that goal through child access prevention (CAP) laws, which sanction gun owners for unsafe firearm storage. However, recent survey data suggests that these laws are not effective, as they suffer from low compliance. To compensate for these shortcomings, legislators should repeal CAP laws and devise legislation requiring gun owners residing with children to retrofit their household firearms with smart gun technology.
Raised by machines—Children's collection of information as a catalyst for the creation of AI complaisant consumers
Authors: Matchton Juliette 
Published: July 2024

AbstractPrivacy laws have yet to effectively deal with the ever‐growing implementation of predictive technologies, such as artificial intelligence (AI), making critical decisions for children. To resolve this issue, COPPA should be revised, and a new division of the Federal Trade Commission (FTC) should be created to provide a central informational source on the risks related to AI− a more effective means for parents to determine what types of data are being collected and used by AI, and allow parents to provide prior express consent for such usage.
Among‐species variation in six decades of changing migration timings explained through ecology, life‐history and local migratory abundance
Authors: Dale Vicki R. , Bolton Mark , Dornelas Maria , Magurran Anne E. , Dennis Roy , Broad Roger , Riddiford Nick J. , Harvey Paul V. , Riddington Roger , Shaw Deryk N. , Parnaby David , Reid Jane M. 
Published: July 2024

AbstractSpecies exploiting seasonal environments must alter timings of key life‐history events in response to large‐scale climatic changes in order to maintain trophic synchrony with required resources. Yet, substantial among‐species variation in long‐term phenological changes has been observed. Advancing from simply describing such variation towards predicting future phenological responses requires studies that rigorously quantify and explain variation in the direction and magnitude of changing timings across diverse species in relation to key ecological and life‐history variables. Accordingly, we fitted multi‐quantile regressions to 59 years of multi‐species data on spring and autumn bird migration timings through northern Scotland. We demonstrate substantial variation in changes in timings among 72 species, and tested whether such variation can be explained by species ecology, life‐history and changes in local abundance. Consistent with predictions, species that advanced their migration timing in one or both seasons had more seasonally restricted diet types, fewer suitable breeding habitat types, shorter generation lengths and capability to produce multiple offspring broods per year. In contrast, species with less seasonally restricted diet types and that produce single annual offspring broods, showed no change. Meanwhile, contrary to prediction, long‐distance and short‐distance migrants advanced migration timings similarly. Changes in migration timing also varied with changes in local migratory abundance, such that species with increasing seasonal abundance apparently altered their migration timing, whilst species with decreasing abundance did not. Such patterns broadly concur with expectation given adaptive changes in migration timing. However, we demonstrate that similar patterns can be generated by numerical sampling given changing local abundances. Any apparent phenology‐abundance relationships should, therefore, be carefully validated and interpreted. Overall, our results show that migrant bird species with differing ecologies and life‐histories showed systematically differing phenological changes over six decades contextualised by large‐scale environmental changes, potentially facilitating future predictions and altering temporal dynamics of seasonal species co‐occurrences.
Factors affecting nutrient losses in hay production
Authors: Zamudio Diego , Killerby Marjorie A. , Charley Robert C. , Chevaux Eric , Drouin Pascal , Schmidt Renato J. , Bright Jhon , Romero Juan J. 
Published: July 2024

AbstractThe primary objective of haymaking is to dry forage adequately to inhibit the growth of undesirable microbes and halt residual plant enzymatic activity that causes nutrient losses. During the field and storage phases of haymaking, the environment, management practices, and other factors influence the extent of dry matter losses. This review discusses these factors and the strategies that have been developed to mitigate nutrient losses. A major emphasis was placed on hay microbiome dynamics, as it has been scarcely studied despite its importance on nutrient losses during storage and harvest, especially under humid conditions. The effects of cutting height, mower type, and swath manipulation on soil contamination were discussed. Also, the impact of environmental conditions and swath manipulation on wilting time was analysed for humid and arid conditions. Special attention was given to design improvements in harvesting equipment to reduce wilting time and field losses. Furthermore, we assessed the nutrient losses during storage caused by microbial and residual plant enzymatic activity resulting from excessive moisture at baling or re‐introduced moisture during storage. The spoilage extent during storage depends on bale moisture, size, density, shape, wrapping, forage type, and storage facilities. A Venn diagram analysis showed that each phase of haymaking process has a unique microbiome and that certain fungal and bacterial genera could be shared across more than one hay production phase. To take corrective actions, hay producers need to be aware of the increased susceptibility to nutrient losses associated with particular field and storage practices, environmental conditions, and forage types.
Investigating effects of sintering mean residence time on engineering properties of coal ash‐based lightweight aggregate
Authors: Alqenai Yousif , Balapour Mo , Zooyousefin Mohammadamin , Shresthal Nishant , Hsuan Y. Grace , Farnam Yaghoob (Amir) 
Published: July 2024

AbstractThis study examines the effect of sintering mean residence time (MRT) on the engineering properties and morphological structure of lightweight aggregates (LWA) manufactured from waste coal combustion ash (W‐CCA). A thermodynamics‐based framework was used to tune LWA manufacturing processes. A minimum 35% liquid phase (by mass) and a lower bound viscosity of 100 Pa·s of molten material were found necessary to successfully produce LWA. Using W‐CCA's chemical composition and FactSage thermodynamic modeling, the sintering temperature for LWA was set to 1075°C. Green spherical pellets made using a pelletizer were sintered at MRT of 5.1, 14.8, and 25.9 min to test LWA physical‐mechanical properties including, unit weight, specific gravity, water absorption, and compressive strength. Results indicated that unit weight ranged from 752 to 800 kg/m3, providing desirable lightweight properties. Oven dry specific gravity ranged from 1.24 to 1.43, complying with ENI13055 specification for LWA. Water absorption capacity decreased as MRT extended from 5.1 to 14.8 min and then increased as MRT proceeded from 14.8 to 25.9 min, achieving an average absorption capacity of 26% ± 1.5%. The inverse effect was noticed for compressive strength as LWA sintered with an MRT of 14.8 min demonstrated the highest compressive strength of 14.7 ± 1.8 MPa. The initial decrease in water absorption and increase in compressive strength are attributed to the efficient sintering of the LWA's internal structure. The inverse effect observed as MRT proceeded from 14.8 to 25.9 min was believed to be a result of thermal cracking due to extensive heat exposure. MRT of 14.8 min is recommended for LWA production using the coal ash utilized in this study for its buoyancy characteristics, sufficient absorption capability, and higher compressive strength.
Impact of oligosaccharides on probiotic properties and B vitamins production: a comprehensive assessment of probiotic strains
Authors: Yin Jia , Peng Xiaoxia , Yang Aijun , Lin Mudi , Ji Kunfa , Dai Xiaohui , Huang Juan , Li Li , Feng Like 
Published: July 2024

SummaryFrom recent literature and research studies, it has been found that some bacterial strains have abilities with probiotic activities to produce B vitamins, which play essential roles in maintaining human health. Oligosaccharides can promote the beneficial microbes, however, the specific effects of oligosaccharides on B vitamins‐producing ability of probiotic strains have not been clarified. This study evaluated the effect of different oligosaccharides on the probiotic properties and B vitamin‐producing ability of 21 selected probiotic strains. The obtained results suggested that the strains could utilise oligosaccharides as the sole carbon source, and the hydrophobicity, auto‐aggregation, and biofilm formation of probiotic strains were specific regulated after fermentation with different oligosaccharides. In particular, the oligosaccharides had different influences on the levels of extracellular B vitamins produced by probiotic strains. These findings provide the foundation for studies on the B vitamins‐producing probiotic strains and their application in functional foods to prevent B vitamins deficiency.
International Council for Standardization in Haematology (ICSH) recommendations for the performance and interpretation of activated partial thromboplastin time and prothrombin time mixing tests
Authors: Adcock D. M. , Moore G. W. , Kershaw G. W. , Montalvao S. A. L. , Gosselin R. C. 
Published: July 2024

AbstractThis guidance document has been prepared on behalf of the International Council for Standardization in Haematology (ICSH). The aim of the document is to provide guidance and recommendations for the performance and interpretation of activated partial thromboplastin time (APTT) and prothrombin time (PT) plasma mixing tests in clinical laboratories in all regions of the world. The following areas are included in this document: preanalytical, analytical, postanalytical, and quality assurance considerations as they relate to the proper performance and interpretation of plasma mixing tests. The recommendations are based on good laboratory practice, published data in peer‐reviewed literature, and expert opinion.
Reality or illusion: A qualitative study on interviewer job previews and applicant self‐presentation
Authors: Schmitz‐Wilhelmy Annika , Truxillo Donald M. 
Published: July 2024

AbstractJob interviews involve an exchange of information between interviewers and applicants to assess fit from each side. But current frameworks on interviewers' job previews and applicants' self‐presentation do not completely capture these exchange processes. Using a grounded theory approach, we developed a theoretical model that spans both literatures by showing the complex relationships between job previews and self‐presentation in the interview. Our study also introduces a new way of categorizing applicant self‐presentation and reveals why interviewers and applicants choose to use certain strategies. Based on 43 qualitative interviews with applicants and interviewers, we identified five dominant applicant self‐presentation responses to job preview information: Receding from the Application Process, Reciprocating Reality, Exploiting the RJP, Resisting in Defiance, and Reciprocating Illusion. Furthermore, we found that applicants present many versions of themselves that not only include their actual, favorable, and ought self but also their anticipated‐future self. We also identify interviewers' and applicants' conflicting motives for presenting reality and illusion. Our work provides a deeper understanding of job previews and self‐presentation by providing a big‐picture, yet fine‐grained examination of the communication processes from the viewpoint of the applicant and the interviewer, illustrating implications for both parties and proposing new avenues for research.
Bolstering the transfer of expatriate training: A conceptual model integrating the roles of accountability and identity
Authors: Grossman Rebecca , Burke‐Smalley Lisa A. , Panton Kareem 
Published: July 2024

AbstractAlthough organizations increasingly rely on and invest heavily in expatriate assignments, a large proportion of these assignments fail. Given a notable gap in the expatriate literature, we advance a conceptual model focused on improving transfer of expatriate training to the host country work role as a means of addressing these challenges. We integrate relevant theory on expatriate cross‐cultural training, expatriate identity, and accountability for transfer to propose a conceptual model that delineates specific mechanisms through which the transfer of expatriate training, and ultimately expatriate adjustment, can be facilitated. Our model and specific research propositions are premised on the role of identity due to its centrality in developing a sense of accountability for transferring training, and its relevance to the success of expatriate assignments. The propositions and practical recommendations, unlike existing transfer strategies that are sometimes atheoretical or implemented haphazardly, are anchored in a common lens of accountability and identity. By doing so, we uniquely provide systematic and strategic insight about efforts to improve expatriate training, thus facilitating expatriation. A conceptual model and testable research propositions provide numerous pathways for advancing future research focused on the success of expatriate assignments through training. Practical guidance and recommendations, as yoked to a shared theoretical foundation, are presented to help organizations and managers bolster the transfer of expatriate training.
Effects of long‐term desmopressin treatment for nocturia in older people
Authors: Kurose Hirofumi , Ueda Kosuke , Chikui Katsuaki , Uemura Keiichiro , Nishihara Kiyoaki , Nakiri Makoto , Suekane Shigetaka , Igawa Tsukasa 
Published: July 2024

ObjectivesDesmopressin improves nocturia frequency; however, reports on its long‐term efficacy and safety are few, and concerns regarding its effect on body composition exist. We thus investigated the efficacy and safety of long‐term desmopressin administration and its effect on body composition.MethodsThis retrospective study, conducted at Chikugo City Hospital between August 2020 and December 2022, involved 133 men (mean age, 77.7 years) with nocturnal and persistent nocturia, who were administered an initial dose of 50 μg desmopressin. Efficacy endpoints included nocturnal urinary frequency, nocturnal urinary volume, hours of undisturbed sleep, nocturnal polyuria index, initial nocturnal urinary volume, and daily urinary frequency in a frequency‐volume chart (3 days), before treatment and at 1, 4, 12, 24, and 52 weeks after desmopressin administration. Additionally, the effects of desmopressin on body composition were examined, including blood–brain natriuretic peptide and a chest radiography, before and 52 weeks after administration.ResultsTreatment improved most efficacy endpoint evaluation parameters. Around 87.6% of patients showed improved symptoms after 52 weeks compared with those before treatment (score ≤ 3). The blood–brain natriuretic peptide level rose; however, cardiothoracic ratio was unchanged.ConclusionLong‐term administration of desmopressin is thus effective and safe in older people with nocturnal polyuria, with little effect on body composition.
Adrenalectomy for pheochromocytoma: Surgical outcomes and preoperative risk factors for hemodynamic instability
Authors: Suzuki Kotaro , Okamura Yasuyoshi , Bando Yukari , Hara Takuto , Okada Keisuke , Terakawa Tomoaki , Hyodo Yoji , Chiba Koji , Teishima Jun , Nakano Yuzo , Miyake Hideaki 
Published: July 2024

BackgroundSurgical resection for pheochromocytoma (PCC) is still challenging. This study assessed the perioperative outcomes of adrenalectomy for PCC and investigated the risk factors for intraoperative hemodynamic instability (HI).MethodsThis retrospective study included 571 patients with adrenal tumors who underwent adrenalectomy at Kobe University Hospital and other related hospitals between April 2008 and October 2023. The perioperative outcomes of laparoscopic adrenalectomy were compared between PCC (n = 92) and non‐PCC (n = 464) groups. In addition, we investigated several potential risk factors for intraoperative HI in patients with PCC (n = 107; open, n = 11; laparoscopic, n = 92; robot‐assisted, n = 4).ResultsWhile patients with PCC had a significantly larger amount of blood loss in comparison to those with non‐PCC (mean, 70 and 30 mL, respectively; p = 0.004), no significant difference was observed in the rate of perioperative grade ≥III complications (1.1% vs. 0.6%; p = 0.516), and no perioperative mortality was observed in either group. A tumor size of ≥40 mm, with preoperative hypertension and urinary metanephrines at a level ≥3 times the upper limit of the normal value, were found to be significant predictors of HI, with odds ratios of 2.74 (p = 0.025), 3.91 (p = 0.005), and 3.83 (p = 0.004), respectively.ConclusionsOur data suggest that laparoscopic adrenalectomy for PCC may be as safe as that for other types of adrenal tumors and that large tumors and hormonally active disease may be risk factors for intraoperative HI. The optimal perioperative management for PCC with these risk factors should be established.
Juvenile hormone‐induced microRNA miR‐iab‐8 regulates lipid homeostasis and metamorphosis in Drosophila melanogaster
Authors: He Qianyu , Chen Shanshan , Hou Tianlan , Chen Jinxia 
Published: July 2024

AbstractMetamorphosis plays an important role in the evolutionary success of insects. Accumulating evidence indicated that microRNAs (miRNAs) are involved in the regulation of processes associated with insect metamorphosis. However, the miRNAs coordinated with juvenile hormone (JH)‐regulated metamorphosis remain poorly reported. In the present study, using high‐throughput miRNA sequencing combined with Drosophila genetic approaches, we demonstrated that miR‐iab‐8, which primarily targets homeotic genes to modulate haltere‐wing transformation and sterility was up‐regulated by JH and involved in JH‐mediated metamorphosis. Overexpression of miR‐iab‐8 in the fat body resulted in delayed development and failure of larval‐pupal transition. Furthermore, metabolomic analysis results revealed that overexpression of miR‐iab‐8 caused severe energy metabolism defects especially the lipid metabolism, resulting in significantly reduced triacylglycerol (TG) content and glycerophospholipids but enhanced accumulation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE). In line with this, Nile red staining demonstrated that during the third larval development, the TG content in the miR‐iab‐8 overexpression larvae was continuously decreased, which is opposite to the control. Additionally, the transcription levels of genes committed to TG synthesis and breakdown were found to be significantly increased and the expression of genes responsible for glycerophospholipids metabolism were also altered. Overall, we proposed that JH induced miR‐iab‐8 expression to perturb the lipid metabolism homeostasis especially the TG storage in the fat body, which in turn affected larval growth and metamorphosis.