bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximizing Productivity of Cucumber (Cucumis sativa L) Applied with Bio-Stimulant Solution
Authors: Oñal, Jr. Paulino A , Lapas Patricia S. , Servino Rizzi Ann S. , Andrade Francis E. , Cortez Manuel D. , Baldonebro Jessel Jane G. 
Published: August 2024

The study sought to determine the effects of different levels of concentrations of bio-stimulant solution (BSS) in enhancing the growth and maximizing the yield of the cucumber plant. The study was conducted at UNO-R School of Agriculture, Philippines, last January 8, 2024, to March 18, 2024. The study was laid out in (CRD) with four treatments and replicated 4 times. The BSS solution was diluted in the water. It was applied at the base of the vine following the research protocol. Statistical analysis revealed highly significant differences among the treatments in growth and yield parameters such as length of vine and weight of marketable fruits, respectively. Likewise, results showed highly significant differences among treatments on flower initiation, number of leaves, number of fruits, circumference, and diameter of fruits, biomass, and root weight. For the longest vine, greater number of leaves, early flower initiation, great number of fruits, greater length and bigger circumference of fruits, heavier weight of fruits, heavier roots, and biomass accumulation were obtained from plants applied with 400ml BSS, followed by 300ml BSS, and 200ml BSS, respectively. While those who have no BSS had the lowest result in almost all of the parameters mentioned above. Four growth characteristics are strongly correlated with the length of vines, and three for the root weight, respectively. This study recommends the use of 400ml BSS in enhancing the growth and maximizing the yield of cucumber.
Manyi and Zhen as Seen from the Hujia Caochang Han Manuscripts
Authors: Watanabe Hideyuki 
Published: August 2024

Abstract
The Hujia caochang Western Han slip-and-tablet manuscripts include statutes on the manyi 蠻夷 and zhen 真, which contain unprecedented but significant information. From the Qin to the early Han periods, foreign tribes were divided into two categories: the wai manyi 外蠻夷 and the jiaozhong manyi 徼中蠻夷. Delineating them was the “boundary” called jiao 徼 and sai 塞, and the management of these tribes also differed. The Han dynasty ruled the foreign tribes within its border by such means as household registration by dao 道-march officials, provision of farmlands based on their registers, imposition of land tax and corvée service, recognition of the original status of the ruling classes, and control by Han law. However, the jiaozhong manyi maintained their original residential form, which were different from the ordinary junxian 郡縣 residents. The manyi were under the rule of the manyi zhang 蠻夷長 and others, but were also controlled by the law of the Han dynasty. In addition, the Han inherited the Qin legal notion of zhen as the label for naturalized people from abroad. Zhen refers to the “pure” people born abroad, that is, the first generation of naturalized foreigners. Nonetheless, their children born on the land of Han were no longer regarded as zhen, but as complete Han people. As for naturalized zhen, the dynasty partially recognized their original status or identity.
Changes in Skeletal Muscle Volume During Preoperative Chemotherapy Affect the Outcome of Pancreatic Cancer
Authors: Matsumoto Michinori , Shirai Yoshihiro , Tsunematsu Masashi , Okui Norimitsu , Gocho Takeshi , Onda Shinji , Furukawa Kenei , Haruki Koichiro , Uwagawa Tadashi , Ikegami Toru 
Published: August 2024

Background This study aimed to investigate the effects of changes in clinicopathological factors during preoperative chemotherapy for pancreatic cancer, including skeletal muscle volume, on recurrence and prognosis after pancreatectomy. Methods Data from 41 patients who underwent resection for pancreatic cancer after preoperative chemotherapy from 2012 to 2021 were retrospectively reviewed. Skeletal muscle volume was substituted for the psoas muscle area (PMA) at the level of the third lumbar vertebra. We investigated the relationship of clinicopathological factors during preoperative chemotherapy with disease-free survival (DFS) and overall survival (OS). The association between clinicopathological factors and a decrease in PMA was investigated. Results In the multivariate analyses for DFS and OS, the factors associated with recurrence were as follows: decrease in PMA ( P = 0.003) and the absence of adjuvant therapy ( P = 0.03), and the factors associated with poor prognosis were as follows: decrease in PMA ( P = 0.04) and the absence of adjuvant therapy ( P = 0.008), and the resectability of borderline resectable and unresectable-locally advanced tumors ( P = 0.033). All patients with partial response according to the Response Evaluation Criteria in Solid Tumors (version 1.1) had no decrease in PMA ( P = 0.01). The proportion of patients with Evans classification ≥ II was significantly higher in the group without a decrease in PMA ( P = 0.02). The proportion of patients with an average relative dose intensity of adjuvant therapy ≥0.6 was significantly higher in the group without a decrease in PMA ( P = 0.02). Conclusion Changes in preoperative skeletal muscle volume during preoperative chemotherapy for pancreatic cancer is a potential predictor of recurrence and prognosis after pancreatectomy.
From PROBE to net zero: A study of soft landings’ contribution
Authors: Mirzaie Sahar 
Published: August 2024

This study reviews Soft Landings (SL) implementations, focusing on its role in achieving Low and Net Zero Emission (LZE) buildings and reducing the energy performance gap. With buildings contributing significantly to global carbon emissions, it is crucial to understand the effect of integrating approaches like SL for meeting Net Zero goals. Notably, this research identified that the extended 3-year aftercare phase of SL does not always lead to reduced operational carbon emissions. While SL promotes collaboration and structured delivery, its overall impact on consistently achieving LZE buildings remains unclear, largely due to insufficient in-use performance data. The paper advocates for integrating SL with other performance-based methods, emphasising the need for enhanced industry collaboration and data sharing to augment the understanding and effectiveness of SL in delivering LZE buildings. Practical Application: This paper offers a thorough analysis of the Soft Landings (SL) framework in achieving Low and Net Zero Emission (LZE) buildings. It examines barriers at each project lifecycle stage and evaluates SL’s effectiveness through case studies, revealing inconsistencies in reducing operational emissions. The findings emphasise integrating SL with performance-based initiatives and enhancing industry collaboration and data sharing. Built environment professionals can leverage these insights to improve project delivery, optimise building performance, and achieve LZE goals more effectively.
Swedish Translation and Cultural Adaptation of the Head and Neck Patient Symptom Checklist: An Instrument to Screen for Nutrition Impact Symptoms in Clinical Practice and Research
Authors: Tiblom Ehrsson Ylva , Einarsson Sandra , Fransson Per , Laurell Göran 
Published: August 2024

Background: The Head and Neck Patient Symptom Checklist (HNSC) is a validated 2-part instrument used to ask patients with head and neck cancer about the nutrition impact symptoms they experience (part 1) and how these interfere with their eating (part 2). Purpose: The purpose of this work was to translate and culturally adapt the HNSC into Swedish in accordance with the guidelines of the International Society for Health Economics and Outcomes Research (ISPOR). Methods: The ISPOR guidelines include 10 steps, and these were thoroughly followed. In step 7, 9 health care professionals from the field of head and neck cancer assessed the perceived relevance (content validity) of each item in the HNSC, as well as the full HNSC. A total of 522 participants with head and neck cancer were included and followed up on 7 occasions using the HNSC to assess internal consistency. Results: The HNSC was translated from English into Swedish, ensuring accuracy through forward and backward translation and harmonization in the research team. Content validity for each part of the HNSC was rated excellent (scale content validity index 0.96). Internal consistency demonstrated a good Cronbach’s alpha score (>0.8) across the 7 follow-up time points (from baseline [before the start of treatment] and up to 24 months posttreatment). Conclusions: The HNSC has been successfully translated and culturally adapted into Swedish. The HNSC can be used in both clinical practice and research to screen for nutrition impact symptoms and symptoms that interfere with eating in patients with head and neck cancer. Trial registration: ClinicalTrials.gov NCT03343236 (date of registration: November 17, 2017)
Assessment of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic immune-inflammatory index, as diagnostic markers for neonatal sepsis
Authors: Zhu Shanshan , Zhou Qian , Hu Zhonghua , Jiang Junsheng 
Published: August 2024

Objective To assess the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII), as diagnostic markers for neonatal sepsis. Methods This retrospective study involve neonates with sepsis and healthy neonates as controls. NLR, PLR, and SII were compared between groups. Result In total, 60 neonates with sepsis and 60 healthy controls were involved in the study. Compared with controls, the sepsis group had higher values for NLR, PLR and SII. Logistic regression analysis suggested that the NLR, PLR and SII were independent risk factors for neonatal sepsis. In addition, receiver operating characteristic (ROC) curve analysis indicated that the NLR, PLR and SII were reliable predictors of neonatal sepsis and SII had the best predictive value. Conclusions NLR, PLR and SII appear to be useful indicators for predicting neonatal sepsis.
Community-Based Residential Relocation in Middle and Older Age: A United States–China Comparison Study on Its Predictors and Associated Mortality Risk
Authors: Lu Peiyi , Kong Dexia 
Published: August 2024

Objectives This study compared the United States and China in examining the predictors of community-based residential relocation and its associated mortality risk. Methods Data from the 2010 to 2018 US Health and Retirement Study and from 2011 to 2018 China Health and Retirement Longitudinal Study were used (NUS = 20,292 and NChina = 11,694). Community-dwelling respondents (aged 50+) reported whether they had relocated and were followed up until 2018. Log-binomial regression and Cox survival analysis were used. Results In both countries, younger age, higher education, urban residence, and being a renter were associated with higher likelihood of relocation. Community-based relocation was associated with a lower mortality risk (US: HR = 0.63, 95% CI = 0.57, 0.70; China: HR = 0.40, 95% CI = 0.31, 0.50), and this association was significantly stronger in China compared to the United States. Discussion Common predictors of community-based relocation were found in the United States and China. The relocation-related survival advantages may be attributed to a better post-move adaptation and living environment.
Computational analysis of the biomechanical stability of internal fixation of the lateral tibial plateau fracture: A mechanical stability study
Authors: Li Yafeng , Lu Fengyuan , Yi Peng , Zou Zichun , Zhang Xi , Zhang Jing 
Published: August 2024

The selection of internal fixation as the primary fixation modality for the patient is one of the challenges for the surgeon treating the patient in question. A model of the lateral tibial plateau fracture was established. Three different configurations of internal fixators namely L bone plate, T bone plate, and screw-washer were analyzed. Three stages after surgery were simulated to assess the displacement of bone plates, screws, washers, and the stress shielding ratio in the fracture area. At three stages after surgery, the T bone plate showed better stability for patients during rehabilitation compared with the remaining two schemes, and the screw-washer scheme was the least stable due to the larger internal fixation displacement and stress shielding ratio in the fracture area. In contrast, the L bone plate scheme showed better stability in the early stages after surgery but was second only to the screw-washer scheme in the middle and late stages after surgery. The T bone plate showed better stability and became a new selection for surgeons to treat related patients. At three stages after surgery, the T bone plate has better biomechanical stability compared to the L bone plate and screw-washer schemes.
Protocol for Evaluating the Efficacy and Safety of Radiotherapy for Prostate and Oligometastatic Lesions in Patients With Low-Burden Sensitive Oligometastatic Prostate Cancer: An Open, Exploratory Pilot Clinical Trial
Authors: Xu Bichun , Zhao Xianzhi , Feng Zhiru , Li Jialun , Liang Yiyin , Zhang Weiwei , Chen Liang , Shen Xianqi , Qu Min , Gao Xu , Zhang Huojun 
Published: August 2024

Introduction The existing large prospective study demonstrates the benefits of primary radiotherapy in patients with low-volume oligometastatic prostate cancer (OMPC), and there is additional evidence of the benefits of local metastasis-directed therapy (MDT) for metastatic lesions. However, there are no results from a prospective study to demonstrate the efficacy of radiotherapy for prostate and oligometastases. Therefore, the aim of the protocol is to illustrate the efficacy of radiotherapy for prostate and oligometastatic lesions in patients with low-volume de novo hormone-sensitive OMPC. Methods and analysis This study involves a prospective, single-center, limited-sample, single-arm exploration of radiotherapy for prostate and oligometastatic lesions in patients diagnosed with low-volume hormone-sensitive OMPC. Eligible participants undergo thorough assessments and treatment involving endocrine therapy alongside radiation targeting metastatic lesions and the pelvic region. The primary site is treated with volumetric modulated arc therapy (VMAT), while metastatic sites are treated with either VMAT or stereotactic body radiation therapy (SBRT) depending on their location. All patients received radiation therapy for both the primary and metastatic lesions combined with endocrine therapy. Endocrine therapy with an antiandrogen (bicalutamide, for 4 weeks) androgen deprivation therapy combined with novel hormonal agents (acetate abiraterone) will be continued for 2 years. The primary objective is to evaluate progression-free survival-2 (PFS-2), while secondary endpoints include androgen deprivation therapy (ADT)-free survival, quality of life (QoL), overall survival, time to castration-resistant prostate cancer (CRPC), radiation-related complications, and endocrine therapy-related adverse events. Ethics and dissemination Approval was obtained from the ethics committee of the First Affiliated Hospital of Naval Medical University (CHEC2023-220). This is a single-arm exploration pilot trial evaluating radiotherapy for prostate and oligometastatic lesions in patients with OMPC. It aims to disseminate its findings through peer-reviewed journals and relevant medical conferences, with the intention of publication and presentation at these events. Trial registration numbers Clinicaltrials.gov identifier NCT06198387.
Dietary Habits and Determinants of Overnutrition Among Secondary and Preparatory School Adolescents: A Multi-Center Unmatched Case-Control Study
Authors: Abeje Eleni Dagnaw , Aynalem Shiferaw Birhanu , Workie Hailemariam Mekonnen 
Published: August 2024

Background: Overnutrition is characterized by abnormal or excessive fat buildup in the body’s fatty tissue, leading to potential health issues associated with overweight or obesity. These conditions pose significant public health challenges for adolescents and are strong indicators of future obesity, illness, and even death. As a result, this study sought to examine the dietary behaviors and factors contributing to overnutrition in secondary and preparatory school students in Debre Berhan Town, Ethiopia. Methods: An institutional-based unmatched case-control study was conducted among 285 adolescents from March 18 to April 20, 2021. The data collection was carried out using standardized interviewer-administered semi-structured questionnaires, which were adapted from previous studies. A general survey was conducted to identify cases and controls. The cases and controls were selected using simple random sampling methods. Data was entered using Epi-data 4.2 software and exported to SPSS v25. Descriptive statistics were done based on the nature of the data. Bivariable and multivariable logistic regression analysis was performed. World Health Organization AnthroPlus software was used to analyze anthropometric data into body mass index for age with z-score. Adjusted odds ratio with a 95% confidence interval and P-value <.05 was considered statistical significance. Result: In this study, eating habits while reading (AOR = 3.87;95% CI: 1.95-7.686), sedentary behavior, (AOR = 2.52; 95% CI: 1.278-4.97), vigorous type of physical exercise for <75 min per week (AOR = 2.38; 95% CI: (1.149-4.92), <6 sleeping hour per day (AOR = 5.68; 95% CI: 2.08-15.48) and earning an average family income of ≥227 USD (AOR = 2.67; 95% CI: 1.214-5.9) were significantly associated with overnutrition among school adolescents. Conclusion: Overnutrition is a significant emerging public health concern among school adolescents, with various factors contributing to its prevalence. This study underscores the importance of promoting an active lifestyle, reducing sedentary behavior, and fostering healthy eating habits as crucial national public health priorities. Early interventions targeting modifiable risk factors are essential for mitigating the incidence of overnutrition among adolescents. It is recommended that educational programs addressing overnutrition and its associated health implications commence early in school settings to prevent the escalating prevalence of this issue. Public health initiatives aimed at increasing awareness of risk factors for overnutrition among adolescents are warranted to alleviate the future burden of obesity-related chronic non-communicable diseases.
‘It’s Home for now’: Sense of Home Among Emerging Adults in Permanent Supportive Housing Through the Lens of Ontological Security Theory
Authors: Milligan Tara , Resing Keely , Littman Danielle Maude , Bender Kimberly , Coddington Laura 
Published: August 2024

Not often implemented with emerging adults (18 – 25 years), permanent supportive housing (PSH) is an intervention which aims to support transitions from chronic housing insecurity. Ontological security theory (OST) -- a sense of being whole and alive on a continuous spectrum – serves as a lens to understand this transition. Through longitudinal surveys using semi-structured interview questions, emerging adults living in PSH ( N = 28) in western Colorado described their relationship to the concept of ‘home’ through an OST lens. We found that time in one place as well as emerging adults being able to ponder ‘what’s next’ served as key elements to defining home as well as trust in other residents and staff, consistent policies, a positive sense of safety, and control also impacted residents’ experiences. These findings offer insight into how PSH service providers may support residents and promote OST during unique developmental phases of emerging adulthood.
Antibiotic-induced gut microbiota disruption promotes vascular calcification by reducing short-chain fatty acid acetate
Authors: Zeng Shi-Yu , Liu Yi-Fu , Zeng Zhao-Lin , Zhao Zhi-Bo , Yan Xi-Lin , Zheng Jie , Chen Wen-Hang , Wang Zhen-Xing , Xie Hui , Liu Jiang-Hua 
Published: August 2024

AbstractBackgroundVascular calcification is a common vascular lesion associated with high morbidity and mortality from cardiovascular events. Antibiotics can disrupt the gut microbiota (GM) and have been shown to exacerbate or attenuate several human diseases. However, whether antibiotic-induced GM disruption affects vascular calcification remains unclear.MethodsAntibiotic cocktail (ABX) treatment was utilized to test the potential effects of antibiotics on vascular calcification. The effects of antibiotics on GM and serum short-chain fatty acids (SCFAs) in vascular calcification mice were analyzed using 16 S rRNA gene sequencing and targeted metabolomics, respectively. Further, the effects of acetate, propionate and butyrate on vascular calcification were evaluated. Finally, the potential mechanism by which acetate inhibits osteogenic transformation of VSMCs was explored by proteomics.ResultsABX and vancomycin exacerbated vascular calcification. 16 S rRNA gene sequencing and targeted metabolomics analyses showed that ABX and vancomycin treatments resulted in decreased abundance ofBacteroidetesin the fecal microbiota of the mice and decreased serum levels of SCFAs. In addition, supplementation with acetate was found to reduce calcium salt deposition in the aorta of mice and inhibit osteogenic transformation in VSMCs. Finally, using proteomics, we found that the inhibition of osteogenic transformation of VSMCs by acetate may be related to glutathione metabolism and ubiquitin-mediated proteolysis. After adding the glutathione inhibitor Buthionine sulfoximine (BSO) and the ubiquitination inhibitor MG132, we found that the inhibitory effect of acetate on VSMC osteogenic differentiation was weakened by the intervention of BSO, but MG132 had no effect.ConclusionABX exacerbates vascular calcification, possibly by depleting the abundance ofBacteroidetesand SCFAs in the intestine. Supplementation with acetate has the potential to alleviate vascular calcification, which may be an important target for future treatment of vascular calcification.
Ectopically expressed rhodopsin is not sensitive to X-rays
Authors: Cannon Kelli , Bartley Aundrea , Dobrunz Lynn , Bolding Mark 
Published: August 2024

AbstractVisual perception of X-radiation is a well-documented, but poorly understood phenomenon. Scotopic rod cells and rhodopsin have been implicated in visual responses to X-rays, however, some evidence suggests that X-rays excite the retina via a different mechanism than visible light. While rhodopsin’s role in X-ray perception is unclear, the possibility that it could function as an X-ray receptor has led to speculation that it could act as a transgenically expressed X-ray receptor. If so, it could be used to transduce transcranial X-ray signals and control the activity of genetically targeted populations of neurons in a less invasive version of optogenetics, X-genetics. Here we investigate whether human rhodopsin (hRho) is capable of transducing X-ray signals when expressed outside of the retinal environment. We use a live-cell cAMP GloSensor luminescence assay to measure cAMP decreases in hRho-expressing HEK293 cells in response to visible light and X-ray stimulation. We show that cAMP GloSensor luminescence decreases are not observed in hRho-expressing HEK293 cells in response to X-ray stimulation, despite the presence of robust responses to visible light. Additionally, irradiation had no significant effect on cAMP GloSensor responses to subsequent visible light stimulation. These results suggest that ectopically expressed rhodopsin does not function as an X-ray receptor and is not capable of transducing transcranial X-ray signals into neural activity for X-ray mediated, genetically targeted neuromodulation.