bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foundations of Critical Theory
Authors: Brookfield Stephen D. 
Published: August 2014

The Problem Despite the late 20th century explosion of interest in quality circles, the learning organization, and the habits of effective organizational members, dissatisfaction with organizational life under capitalism and globalization seems to rise exponentially. The financial crisis of 2008, the export of manufacturing jobs, and the rise of the information economy all contribute to worker restlessness and alienation. What theoretical frameworks are most useful to help us understand the way work is experienced as fluctuating and deskilled by many inservice industries and part-time employment? The Solution Critical theory is proposed as one theoretical solution to disentangling this problem. Although crafted in the first half of the 20th century, this attempt to modernize and adapt Marxism has enduring relevance for the 21st century. Its analysis of worker alienation, the fetishization of consumer goods, the commodification of labor, and the way organizations co-opt efforts at structural change are all helpful to Human Resource Development (HRD) practitioners who seek a different perspective on understanding workplace issues. The Stakeholders The article provides examples of how concepts drawn from critical theory can inform scholars’ and practitioners’ understanding of the practice of HRD. Critical theory is proposed as providing a more informed understanding of organizational power dynamics, of the enactment of microaggressions, of the way that labor is commodified, of the production of a social character of capitalism, and of the practice of repressive tolerance.
Feminist Theory and Queer Theory
Authors: Gedro Julie , Mizzi Robert C. 
Published: August 2014

The Problem Although the workforce has become increasingly diverse, there has not been a corresponding interrogation of the assumptions about the ways that demographics, particularly gender, sexual orientation, gender identity, and gender expression, relate to Human Resource Development (HRD) imperatives. The Solution This article will provide justification for why feminist theory and queer theory should be drawn into conversation with each other as useful frameworks for HRD research and scholarship. These frameworks are concerned with “othering” practices and the marginalization that can occur in workplaces, and they can assist HRD scholars and practitioners to expand their knowledge about diversity and inform research and scholarship. The Stakeholders Stakeholders invested in this topic include HRD practitioners and scholars, marginalized people, and, more specifically, women and sexual minorities.
International Critical Perspectives
Authors: Sambrook Sally , Poell Rob F. 
Published: August 2014

The Problem Critical perspectives on human resource development (HRD) have emerged, across Europe and America, hailed as the future of the field. However, we note the paucity of critical perspectives globally, the problematic dominance of critical HRD activities in Western sites of theory and practice, and the apparent dearth in non-Western sites. The Solution We analyze locations of critical HRD to advance understanding of critical perspectives in the international context, raising awareness of where critical HRD operates globally, celebrating its successes, and critically examining its struggles. We hope this encourages colleagues in underrepresented locations to experiment to effect improvements in the lives of otherwise oppressed, marginalized, voiceless workers/learners. The Stakeholders. Critical HRD encompasses attempts to critique and challenge the hegemony of dominant practices in research, education, and practice, around three stakeholders: researchers, educators, and practitioners. Moreover, the purpose of critical HRD is to emancipate workers/learners, the last but not least important stakeholders.
What Type of Leaders Are We? Understanding and Enhancing Critical Human Resource Development Identity in the United States
Authors: Storberg-Walker Julia 
Published: August 2014

The Problem These are the days of grand, interdisciplinary, and global challenges. For example, there is widespread acknowledgment within the scientific community that climate change is happening. The financial meltdown caused thousands of families to lose their homes, and environmental debacles like the BP oil disaster in the Gulf of Mexico generated economic, social, and public health concerns.These are problems—not necessarily human resource development (HRD) problems—but problems nonetheless that impact the people, communities and organizations we lead and serve.We are the leaders, change agents, consultants, and educators whom organizations, communities, and people turn to for their development and training needs. The Solution I believe HRD scholars should proactively develop a critical orientation to economic, social, cultural, and environmental issues currently plaguing the planet. With such a critical perspective, we can develop a CHRD leadership identity and challenge hidden assumptions and work with others to expose environmental, human, and economicexploitation.The accomplish this goal, I believe, we should examine the historical emergence of critical HRD identities and thenintentionally create critical leadership development opportunities for more HRD professionals to enact critical HRD more of the time. The Stakeholders Communities, individuals, organizations, the planet.
Formation of linearly linked Fe clusters on Si(111)-7 × 7-C2H5OH surface
Authors: Ding Wanyu , Ju Dongying , Guo Yuanyuan , Tanaka Ken-ichi , Komori Fumio 
Published: August 2014

Abstract
The Fe atoms were deposited on the Si(111)-7 × 7 surface, which has been saturated with the C2H5OH molecules. Then, the Fe clusters were formed on Si(111)-7 × 7-C2H5OH surface and in situ observed by the scanning tunneling microscopy (STM). The STM images showed that with the increase of Fe clusters, the size of clusters was about 5 nm and they self-assembled in straightly linked chain crossing the step to lower or upper terrace. X-ray photoelectron spectroscopy (XPS) was in situ carried out on the surface of Fe/Si(111)-7 × 7-C2H5OH samples before and after the introduction of thin air (4.5 × 10-2 Langmuir) into the STM chamber. The XPS results showed that the Fe clusters are stable in the abovementioned thin air condition at room temperature. Based on the STM and XPS results, the driving force making one-dimensional straightly linked chain structure might be the magnetic force of the Fe clusters. The formation of straightly linked Fe clusters chains suggests the formation of single magnetic domain Fe clusters.

PACS

07.79.Cz, 81.15.-z, 75.75.Fk
Controlled growth of 1D and 2D ZnO nanostructures on 4H-SiC using Au catalyst
Authors: Dahiya Abhishek Singh , Opoku Charles , Alquier Daniel , Poulin-Vittrant Guylaine , Cayrel Frederic , Graton Olivier , Hue Louis-Pascal Tran Huu , Camara Nicolas 
Published: August 2014

AbstractA perfect control of nanostructure growth is a prerequisite for the development of electronic and optoelectronic device/systems. In this article, we demonstrate the growth of various ZnO-derived nanostructures, including well-ordered arrays of high aspect ratio single crystalline nanowires with preferred growth direction along the [0001] axis, nanowalls, and hybrid nanowire-nanowall structures. The growths of the various ZnO nanostructures have been carried out on SiC substrates in a horizontal furnace, using Au thin film as catalyst. From experimental observations, we have ascribed the growth mechanisms of the different ZnO nanostructures to be a combination of catalytic-assisted and non-catalytic-assisted vapor–liquid-solid (VLS) processes. We have also found that the different ZnO nanoarchitectures' material evolution is governed by a Zn cluster drift effects on the SiC surface mainly driven by growth temperature. Au thin film thickness, growth time, and temperature are the parameters to optimize in order to obtain the different ZnO nanoarchitectures.
68Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections
Authors: Ahtinen Helena , Kulkova Julia , Lindholm Laura , Eerola Erkki , Hakanen Antti J , Moritz Niko , Söderström Mirva , Saanijoki Tiina , Jalkanen Sirpa , Roivainen Anne , Aro Hannu T 
Published: August 2014

Abstract

Background

Staphylococcus epidermidis (S. epidermidis) has emerged as one of the leading pathogens of biomaterial-related infections. Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial molecule controlling extravasation of leukocytes. Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a leukocyte ligand of VAP-1. We hypothesized that 68Ga-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated Siglec-9 motif containing peptide (68Ga-DOTA-Siglec-9) could detect inflammatory response due to S. epidermidis peri-implant infection by positron emission tomography (PET).

Methods
Thirty Sprague-Dawley rats were randomized into three groups. A sterile catheter was implanted into the medullary canal of the left tibia. In groups 1 and 2, the implantation was followed by peri-implant injection of S. epidermidis or Staphylococcus aureus (S. aureus) with adjunct injections of aqueous sodium morrhuate. In group 3, sterile saline was injected instead of bacteria and no aqueous sodium morrhuate was used. At 2 weeks after operation, 68Ga-DOTA-Siglec-9 PET coupled with computed tomography (CT) was performed with the measurement of the standardized uptake value (SUV). The presence of the implant-related infection was verified by microbiological analysis, imaging with fluorescence microscope, and histology. The in vivo PET results were verified by ex vivo measurements by gamma counter.

Results
In group 3, the tibias with implanted sterile catheters showed an increased local uptake of 68Ga-DOTA-Siglec-9 compared with the intact contralateral bones (SUVratio +29.5%). 68Ga-DOTA-Siglec-9 PET detected inflammation induced by S. epidermidis and S. aureus catheter-related bone infections (SUVratio +58.1% and +41.7%, respectively). The tracer uptake was significantly higher in the S. epidermidis group than in group 3 without bacterial inoculation, but the difference between S. epidermidis and S. aureus groups was not statistically significant. The difference between the S. aureus group and group 3 was neither statistically significant.

Conclusion
PET/CT imaging with novel 68Ga-DOTA-Siglec-9 tracer was able to detect inflammatory tissue response induced by catheter implantation and staphylococcal infections.
Oligomeric Arylstibonates
Authors: Liu Zun-qi , Ozawa Yoshiki , Yagasaki Atsushi 
Published: August 2014

Abstract
Three oligomeric arylstibonates [H5(p-ClC6H4Sb)16O36]3−, [H4(p-ClC6H4Sb)16O36]4−, and [Na2(p-ClC6H4Sb)12O24(OH)6(H2O)3]4− have been synthesized as tetra-n-butylammonium salts and structurally characterized. The Sb16C16O36 core of the [H5(p-ClC6H4Sb)16O36]3− and [H4(p-ClC6H4Sb)16O36]4− anions is made up from arrays of close-packed O and C atoms and Sb atoms that occupy the octahedral interstices between the close-packed layers. The layers of close-packed O and C atoms are stacked in a sequence ABACA, resulting in an hch packing. The [Na2(p-ClC6H4Sb)12O24(OH)6(H2O)3]4− anion has an “opened-up” δ-Keggin structure.
Types of Lesson for the Primary School in the Context of the Federal State Educational Standards (FSES) Requirements
Authors: Виноградова  , Vinogradova Natalya 
Published: August 2014

The article continues the conversation on modern types of lessons, classified according to the Federal State Educational Standards for Primary
General Education (FSES PGE) requirements to projected results of education. Developing descriptive language and oral skills through special
aspects of creative lessons is reviewed. Various tasks and methods to cultivate verbal creativity are revealed; methodic schemes to promote
creative imagination are outlined.
Endowment in the system of higher education: Management specifics
Authors: Кучин Михаил , Kuchin Mikhail , Бокарева Елена , Bokareva Elena , Егорова Елена , Egorova Elena , Черникова Людмила , Chernikova Lyudmila 
Published: August 2014

Legislation in many countries promotes the creation of endowment as a generator of
value deployed to finance the activities of non-for-profit organizations, which, having built the endowment fund, obtains a steady and long-term source for financing its functions.
De novo design and in-silico studies of novel bis-arylpiperazine derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Authors: Yadav Ashok , Chander Subhash , Lathiya Hiren , Sharma Hardik , Goyal Kriti , Sankaranarayanan Murugesan 
Published: August 2014

In the present study, we have designed some novel bisarylpiperazine derivatives as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Docking studies of the designed analogues were performed by molecular modeling software AutoDock 4.2 using HIV-1 Reverse Transcriptase (PDB ID: 1RT2) as receptor. Lipinskis Rule of Five (Ro5) parameters and toxicity parameters were predicted through online servers like Molinspiration and Osiris property explorer. Docking parameters such as binding free energy and predicted inhibitory constant (Ki) values of the designed analogues were compared with standard drugs Efavirenz and co-crystallized ligand TNK-651. Among the designed analogues,Â 1,Â 4,Â 8,Â 9,Â 12,Â 15,Â 27,Â 30,Â 37,Â 38,Â 39Â andÂ 43Â showed significant and comparable binding free energy and predicted inhibitory constant values as that of standard drugs. These results indicate that, the designed analogues adopt a similar orientation and share the same binding mode as that of some of the classical Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) within the active site of Non-Nucleoside Inhibitory Binding Pocket (NNIBP) of HIV-1 reverse transcriptase.
Synthesis Antimicrobial and Anticancer Activity of 1-[(arylalkylidene)amino]-3-(4H-1,2,4-triazol-4-yl)thiourea
Authors: Kulandaivelu Umasankar , Chawada Bhawatha , Boyapati Shireesha , Reddy Alavala Rajasekhar 
Published: August 2014

Arylalkylidene derivatives of aminotriazoles (3a-3j) were synthesized and tested for their antimicrobial and anticancer activity. Four non-pathogenic bacteria [E. coliÂ (NCIM 2068),Â K. pneumoniaeÂ (NCIM 2957),Â S. aureusÂ (NCIM 2079),Â B. subtilisÂ (NCIM 2921)] two fungi [C. albicans,Â A. niger] and two cancer cell lines [HBL-100 and HT-29] were employed in the study. All the compounds were found to have better antibacterial activity againstÂ B. subtilisÂ than Ciprofloxacin (standard) and compoundÂ 3iÂ was equivalent to Ciprofloxacin in inhibitingÂ S. aureas. Similarly all the compounds inhibited the growth ofÂ A. nigerÂ better than Fluconazole and compoundÂ 3cÂ was equivalent to Fluconazole (standard) in inhibitingÂ C. albicans. In case of anticancer activity none of the molecule exhibited activity better than the standard used (Methotrexate), though they have inhibitory concentration at submicromolar level.
Sex Differences in Inflammatory and Apoptotic Signaling Molecules In Normal and Diseased Human Gingiva
Authors: Johnson Roger B. , Wikle John C. 
Published: August 2014

Background: The purpose of this study is to determine whether sex dimorphism exists in the expression of inflammatory and apoptotic mediators in gingiva obtained from normal and diseased sites of periodontal disease.Methods: Gingival papillae were obtained from individuals (56 males and 62 females) who required extraction of adjacent teeth. Gingival samples were grouped by adjacent sulcus depth: 1 to 3 mm (normal), 3 mm with bleeding on probing (slight disease), 3 to 6 mm (moderate disease), and >6 mm (severe disease). The tissue concentrations of cysteine‐requiring aspartate‐directed protease 3 (caspase‐3), interleukin‐2, tumor necrosis factor–related apoptosis‐inducing ligand, Fas ligand, p38α mitogen‐activated protein kinase, extracellular signal‐related kinase 1/2, and survivin were determined by enzyme‐linked immunosorbent assay. These mediator concentrations, age of donor, sex of donor, and gingival sulcular depth were the outcome variables. Data were compared by factorial analysis of variance, post hoc Tukey, and Pearson correlation test. P <0.05 was used to indicate significant differences among the outcome variables.Results: The mean gingival sulcular depth was significantly greater in male than in female groups (P <0.05). The majority of the tested mediators were significantly correlated with both sex and sulcular depth and with caspase‐3 (P <0.05). The concentration of caspase‐3 in female gingiva at all diseased sites was significantly greater than in gingiva derived from male sites (P <0.05).Conclusions: These data suggest sex dimorphism in the presence of gingival apoptosis at sites of periodontal disease, with females having the highest incidence of apoptosis. Because apoptosis clears inflammatory cells and promotes healing, this phenomenon could provide a mechanism for sex dimorphism for the incidence of periodontal disease.
In Vitro Study on Regeneration of Periodontal Tissue Microvasculature Using Human Dedifferentiated Fat Cells
Authors: Shimizu Yutaka , Sato Soh 
Published: August 2014

Background: Human dedifferentiated fat cells (HDFATs) may be a new cell type suitable for regenerative therapies. The aim of this study is to assess the potential of HDFATs for vascular regeneration of periodontal tissue. To do this, HDFATs and human gingival endothelial cells (HGECs) were cocultivated, and vascular regeneration was examined in vitro.Methods: HDFATs were isolated from subcutaneous adipose tissue, and HGECs were isolated from gingival cells using anti‐cluster of differentiation 31 antibody‐coated magnetic beads. HDFATs were cocultured with HGECs in microvascular endothelial cell growth medium‐2 (EGM‐2MV) for 7 days. Expression of endothelial cell (EC) markers, the formation of capillary‐like tubes, and the expression of pericyte markers were determined.Results: HDFATs, cultured in EGM‐2MV or cocultured with HGECs, expressed EC markers. HDFATs in both conditions initiated tube formation within 5 hours of seeding and formed extensive capillary‐like structures within 12 hours. These structures disintegrated within 24 hours when cells were cultured in EGM‐2MV alone, whereas cocultured HDFATs maintained tubes for >24 hours. Cocultured HDFATs significantly increased expression of pericyte markers, a cell type associated with microvasculature.Conclusion: HDFATs possess the ability to express EC markers, and coculture with HGECs promotes differentiation into pericytes involved in the maturation and stabilization of the microvasculature.
Hypoxic conditions alter developing branchial arch-derived structures in zebrafish
Authors: Parsons Trish E , Weinberg Seth M , Tsang Michael , Vieira Alexandre R 
Published: August 2014

Background: Previous epidemiological findings have implicated hypoxia as a risk factor for craniofacial defects including cleft lip, microtia and branchial arch anomalies. This study tests the hypothesis that hypoxic exposure results in craniofacial shape variation in a zebrafish model. Methods: Three sets of zebrafish embryos were raised in uniform conditions with the exception of dissolved oxygen level. At 24 hours past fertilization (hpf) embryos were placed in hypoxic conditions (70% or 50% dissolved oxygen tank water) and compared to unexposed control embryos. After 24 hours of exposure to hypoxia, the embryos were incubated under normoxia. Larvae were collected at 5 days post fertilization (dpf) and stained for cartilage. Images were taken of each specimen and subsequently landmarked to capture viscerocranial morphology. A geometric morphometric analysis was performed to compare shape variation across groups. Results: The mean branchial arch shape of each exposure group was significantly different from controls (p<0.001). Principal components analysis revealed a clear separation of the three groups, with controls at one end of the shape spectrum, the 50% hypoxia group at the other end, and the 70% hypoxia group spanning the variation in between. Conclusions: This experiment shows that hypoxia exposure at 24hpf is capable of affecting craniofacial shape in a dose-dependent manner. These results may have implications not only for high altitude fetal health, but other environments, behaviors and genes that affect fetal oxygen delivery.
Using the Cytosensor Microphysiometer to Assess Ocular Toxicity
Authors: Nash Jennifer R. , Mun Greg , Raabe Hans A. , Curren Rodger 
Published: August 2014

AbstractMeasuring in vitro cytotoxicity is one method currently used to estimate damage to the eye after chemical exposure. The Cytosensor Microphysiometer method evaluates cytotoxicity by measuring the test material–induced reduction in the metabolic rate of L929 cells. Changes in metabolic rate are measured indirectly as a function of changes in the extracellular acidification rate of the cells. During exposure to increasing concentrations of a cytotoxic material, there is a decrease in the release of acid byproducts into the surrounding medium as the cells die. These acidic metabolic byproducts cause a measurable change in the pH of a lightly buffered medium, which can be measured by the Cytosensor Microphysiometer. The change in the pH of the medium over time is then converted into a metabolic rate estimate for the cells. The endpoint measurement from the assay is the metabolic rate decline of 50%, the MRD50 value (in units of mg/ml). Curr. Protoc. Toxicol. 61:1.13.1‐1.13.11. © 2014 by John Wiley & Sons, Inc.
Current Concepts in Drug‐Induced Bile Salt Export Pump (BSEP) Interference
Authors: Kenna J. Gerry 
Published: August 2014

AbstractNumerous drugs have been shown to inhibit the activity of the Bile Salt Export Pump (BSEP in humans, Bsep in animals), and this is now considered to be one of several mechanisms by which idiosyncratic drug‐induced liver injury (DILI) may be initiated in susceptible patients. The potential importance of BSEP inhibition by drugs has been recognized by the European Medicines Agency and the International Transporter Consortium, who have recommended that it should be evaluated during drug development when evidence of cholestatic liver injury has been observed in nonclinical safety studies or in human clinical trials. In addition, some pharmaceutical companies have proposed evaluation and minimization of BSEP inhibition during drug discovery, when there is a chemical choice, to help reduce DILI risk. The methods that can be used to assess and quantify BSEP inhibition, and key gaps in our current understanding of the relationship between this process and DILI, are discussed. Curr. Protoc. Toxicol. 61.23.7.1:‐23.7.15. © 2014 by John Wiley & Sons, Inc.
Isolation of Endothelial Cells from Mouse Lung
Authors: Cao Gaoyuan , Abraham Valsamma , DeLisser Horace M. 
Published: August 2014

AbstractThe isolation of endothelial cells (ECs) from knockout and transgenic mouse lines provides the opportunity to study the endothelial‐specific activities of a targeted molecule. As a means of pursuing these types of investigations, the protocols described in this unit provide a reliable method for isolating lung microvascular ECs from mouse neonatal pups that can be serially passaged. These protocols are useful in settings where mouse age is irrelevant and a pure population of pulmonary vascular ECs, uncontaminated by other cells, is needed. When a specific source of ECs is not required, these procedures also represent a reliable means of obtaining murine ECs in general. Curr. Protoc. Toxicol. 61:24.2.1‐24.2.9. © 2014 by John Wiley & Sons, Inc.