bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation, Characterization and Biological Study of New Derivatives of 1, 3, 4 - Thiadiazoleand Its Complexes with Some Transitional Element Ions.
Authors: Abd ALsada Alkafiji Naeem , A.flifel Ibrahim 
Published: July 2024

The current study involved preparation of ligand [2,5-bis-(2-(diphenyl methylene) hydrazineyl)-1,3,4-thiadiazole] (L1) from reacting between thiadiazole derivative [ (2,5-dihydrazineyl-1,3,4 -thiadiazol) and Benzphenone by the ratio (1:2) . Attended the transitional elements ions complexes [Cr+3, Fe+3, Co+3, Ni+2, Cu+2] with ligand (L1) Complexes were diagnosed using the precision analysis of elements (C.H.N), Infrared spectrum (FTIR), Spectrum of Nuclear Magnetic Resonance proton (1H-NMR), Mass spectroscopy, measurement magnetic sensitivity and measurement molar conductivity the results were practical exactly matching with the molecular and structural formulas of the proposed compound .Hyperchem was used to draw ligand (L1) and its complexes and to show the distribution of electronic density. Data obtained indicates that the stereochemistry figure of the complexes [Cr+3, Fe+3, Co+3] was octahedral , the proposed stereochemistry figure of the complexes [Ni+2, Cu+2] is square planer. A study was conducted testing the biological activity for the prepared ligand (L1) and its complexes against two types of bacteria staphylococcus aureus and Escherichia coli compared to the standard inhibitor (Cipro.), the results obtained confirmed that ligand(L1) and their complexes did not show any biological activity towards the bacteria aureus staphylococcus aureus, while the ligand(L1) and their complexes showed different activity twards the second type of bacteria Escherichia coli, some showed greater activity than the standard inhibitor and some showed less activity than the standard inhibitor
Co(II),Cu(II),Ni(II),Fe(II)and Cr(III) Complexes of N,O-Type Schiff base ligand derived from 4,4,-methylenedianiline Synthesis, Characterization and antibacterial studies
Authors: N. Deneef Suror , A. Mehdi Hiader 
Published: July 2024

Complexes of Co(II),Cu(II),Ni(II),Fe(II)and Cr(III) were prepared from reaction between (E)-2-(((4-(4-aminobenzyl)phenyl)imino)methyl)phenol and hydrated metal ions such as CoCl2.6H2o,NiCl2.6H2O.FeCl2.6H2O and CrCl3.H2O characterization by analytical and spectra chemical methods .the metal:ligand stoichiometric ratio is 1:1 n the all complexes.it was determined that bidentate behavior of the ligand is accomplished via the phenolic oxygen and the azomethine nitrogen atom .the presence of water revealed by thermogram and supported by the presence of relevant bonds in their IR Spectra. These new complexes showed areasonable amount antibacterial activity.a ligand was synthesized by reaction (4,4'-Methylenedianiline and Salicylaldehyde. The newly synthesized compounds were characterized by Fourier Transform Infrared (FTIR) Spectroscopy, Nuclear Magnetic Resonance Spectroscopy (1H NMR), elemental analyses (C, H, N), mass spectral, conductivity measurement, magnetic sensitivity measurement and atomic Absorption. The mass spectrum of the ligandexhibits a molecular ion peak [M]+.at 302 m/z.
Histopathological Changes of Two Antigens Prepared from Methicillin-Resistant Staphylococcus aureus in Rats
Authors: Zainab Dakhil Degaim  , Wafaa Sadoon Shani  , Saad Salman Hamim  
Published: July 2024

The aim of the present study was to determine the effect of two prepared antigens fromMethicillin-resistantStaphylococcus aureus (MRSA), whichincluded crude alpha toxin (Hla) and heat inactivate bacterial suspension (HIBS) in rats through the examination of the inflammatory response of both antigens on primary and secondary lymphoid organs (thymus gland and spleen), respectively. Examination of sections from spleen of rats treated with HIBS antigen induced high immune response compared with rats treated with Hla antigen which induce mild immune response by established changes. The histological observations on sections from thymus gland of rats treated with HIBS had the ability to induce different changes than Hla antigen compared with control group.
Pathogenicity of Two Nematodes Tetramerese sp. and Microtetramerese Spiralis in Proventriculus of Some Aquatic Birds from Al-Sanaf Marshes in Thi-Qar Province, South of Iraq
Authors: Zainab Abd-Ali Mohammad  , Abdul-Hussein Habash Awad  
Published: July 2024

The present study was carried out to investigate the prevalence and mean of intensity of two nematodes Tetramerese sp. and Microtetrameresespiralis isolated from some of aquatic birds collected from Al-Sanaf marshes, Thi-Qar province.The pathological effects of these parasites on the tissues of the infected aquatic birds were recorded.TheTetramerese sp. females were embedded in glands of proventriculus of the some aquatic birds including: Ardea ralloides, Egretta garazeta, Nycticorax nycticorax, Himantopus himantopus, Larus genei, Bubulicus ibis, Aredea purpurea and Anas clypeata with prevalence 12.57% and mean of intensity 3.00, while the Microtetrameresespiralis embedded in gastric glands of proventriculus of Bubulicusibis with prevalence 10% and mean of intensity 25.00.Histopathological examination of infected tissues showed dilation of the proventericular gland lumen, atrophy, necrosis and degeneration of the glandular cells of proventriculus
Synthesis and Optical Studies of the 3,4-dimethoxy Benzaldehyde [5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]Hydrazone Metal Complexes
Authors: Athraa H. Mekkey  , Fatima H. Mal  , Samah H. Kadhim  
Published: July 2024

The aim of the present study is to synthesize and optical studies of 3,4-dimethoxy benzaldehyde [5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]hydrazone metal complexes. Firstly, the 3,4-dimethoxybenzaldehyde [5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl] hydra zone was synthesized by the reaction of the 2-(5-hydrazino-1,3,4-oxadiazol-2-yl)phenol with 2,3-dimethoxybenzaldehyde in the ethanol as a solvent . Scondly, its complexes of Cr(III), Fe(III), Co(II) and Ni (II) have been synthesized. The synthesized coumpounds and its metal complexes were characterized by the FTIR, Mass spectra and UV-vis absorption. The results confirmed the suggested square planar geometry of the Ni (II) complex and tetrahedral geometry of the Co(II) complex, while Cr (III), Fe(III) complexes were assigned octahedral geometrics. The optical absorption spectra of those complexes in the wavelength range from 200-900 nm were studied.The results showed that the optical absorption is due to indirect allowed transitions of the compound and its complexes, the energy gap (Eg) of these compounds decreases in the order L> Ni (II)> Fe(III)> Co(II) and > Cr(III), the absorption coefficient (α), real and imaginary parts (ɛr,ɛi), and optical conductivity (σopt)were estimated.
Enhancement of Nano Catalyst for an Alkaline Fuel Cells
Authors: Haleemah J. Mohammed  , Nathera A. Ali  
Published: July 2024

An alkaline fuel cell, which was developed using nano catalyst (Pt:CNTs) for electrodes. Study has been prepared (Pt:CNTs) nano catalyst, The Structural characteristics were studied through the analysis of X-ray diffraction (XRD) of the prepared nano catalyst for determining the yielding phase and Scanning Electron Microscope (SEM), were used to characterize, Mesh stainless steel catalyst substrate had an envelope structure and a large surface area. In addition, study the characterization of the electrochemical parameters. Electrochemical modelling and nano catalyst led to optimization of cell voltage, current & power densities and the results are found to be 1.76 V, 3.9 A.
Cabozantinib use in second or subsequent line of treatment in renal cell carcinoma: an analysis of Italian administrative databases
Authors: Lolli Cristian , Verde Antonio , Degli Esposti Luca , Acciai Valentina , Brigido Alessia , Proietti Emanuela , Scagliarini Sarah 
Published: July 2024

Background: Cabozantinib use in everyday clinical practice for advanced or metastatic renal cell carcinoma (RCC) is relatively recent, and real-world data on treatment persistence, adherence and sequencing are still limited.
Methods: We conducted an analysis based on an integrated administrative database, covering around 6.9 million health-assisted Italian individuals, to explore the use of cabozantinib for RCC. Patients with at least one prescription for cabozantinib during 2017-2020 were searched. These were characterized during all available period (i.e. from 2010 onwards) before the index date and were observed after inclusion.
Results: A total of 113 patients treated with cabozantinib in second or subsequent line were included, and their demographic, clinical and treatment characteristics were described. About half of these RCC patients were aged >65 years (47.8%). Sixty patients (53.1%) were highly adherent to cabozantinib therapy, and the median cabozantinib treatment duration of use was 8.7 months (95% confidence interval: 5.8-11.1). During the first year of follow-up, the average total cost per patient was €32,508.
Conclusions: We described second or subsequent line cabozantinib treatment for RCC in a real-world setting and the economic burden of disease in Italy, taking advantage of large, integrated administrative databases.
Pengembangan Inovasi Teknologi Berbentuk Website Direktori sebagai Upaya Branding Desa Wisata di Jawa Timur
Authors: Aji Gilang Gusti , Huda Anam Miftahul , Setianingrum Vinda Maya , Indrajayani Galuh Gita , Andriyanto Andriyanto , Napitupulu Pesta Asni 
Published: July 2024

ENGLISHSeveral regions in Indonesia have developed rural tourism as an effort to increase the economic activities of village communities. However, the development of tourism villages still has obstacles. One of them is related with reliable, interesting, and easily accessible sources of information to get a complete description before carrying out tourism activities in the village. Therefore, the research team examined information needs and media habits, or media consumption habits, as the basis for designing the Dolan Deso directory website in the district area of the ex-karesidenan Kediri. The selection of objects was centered on four districts in East Java, namely Blitar, Trenggalek, Kediri, and Tulungagung, which have tourist villages with good management. In addition, these four districts also have cultural roots, natural views, and attractions that are interesting to promote. The development of this directory website is carried out as a means to facilitate tourists in obtaining information as well as reference materials related to the type of information needed, the character of the media that is often used as a reference by the community, and various features needed as a reference to fulfill information related to Tourism Villages. INDONESIABeberapa wilayah di Indonesia telah mengembangkan Desa Wisata sebagai upaya peningkatan aktivitas ekonomi masyarakat desa, diantaranya di wilayah kabupaten eks-karesidenan Kediri. Namun, pengembangan desa wisata masih memiliki beberapa hambatan, salah satunya terkait sumber informasi terpercaya, menarik dan mudah diakses (accessible) untuk mendapatkan deskripsi lengkap sebelum melaksanakan kegiatan wisata ke desa. Oleh karenanya, im peneliti mengkaji kebutuhan informasi dan media habit atau kebiasaan penggunaan media sebagai dasar untuk perancangan website direktori Dolan Deso di wilayah kabupaten di eks-karesidenan Kediri. Pemilihan objek dipusatkan di 4 kabupaten di Jawa Timur, yakni Blitar, Trenggalek, Kediri dan Tulungagung yang telah memiliki desa wisata dengan manajemen yang baik. Selain itu, keempat kabupaten ini juga telah memiliki akar budaya, pemandangan alam, dan atraksi yang menarik untuk dipromosikan. Pengembangan website direktori ini dilaksanakan sebagai sarana untuk mempermudah wisatawan dalam mendapatkan informasi sekaligus sebagai bahan rujukan terkait jenis informasi yang dibutuhkan, karakter media yang sering dijadikan rujukan oleh masyarakat, dan berbagai fitur yang dibutuhkan sebagai rujukan untuk memenuhi informasi terkait Desa Wisata.
Peningkatan Minat Wirausaha Para Ibu Melalui Pelatihan Pemanfaatan Sumberdaya Lokal (Studi pada Kelompok Sadar Wisata)
Authors: Andayani Tri Rejeki , Wijayanti Pipit , Setyawardhani Dwi Ardiana 
Published: July 2024

ENGLISHThe presence of the Tourism Awareness Group is a tangible manifestation of the tourism awareness movement. Some of local potential around the Maron River has not been utilized optimally. One of them is coconut fruit products which are quite abundant. The involvement of women in the development of Maron River tourism is also not optimal as the involvement of men. The purpose of the research is to increase the entrepreneurial interest of the Maron River Pokdarwis women with local potential. The type of research is experimental with a one-group pretest-posttest design. The research was carried out in August 2023. The research samples are 30 mothers from the Maron River’s Pokdarwis with an average age of 38.3 years (SD+11.92). Data collection using the Entrepreneurship Interest Scale (Rel=0.876) was carried out before and after training. Data analysis was done by descriptive quantitative and inferential statistics using the Wilcoxon Signed Rank Test technique. The results of the analysis showed that there was an increase in the average value of mothers' entrepreneurial interest after attending the training (pretest 98.9, posttest 103.2) with p=0.000 (p<0.05). In other words, training in utilizing local potential can increase the entrepreneurial interest of the women of Maron River’s Pokdarwis. INDONESIAKehadiran Kelompok Sadar Wisata (Pokdarwis) merupakan wujud nyata dari gerakan sadar wisata, yang bertujuan untuk meningkatkan kualitas program atraksi desa serta mendorong keterlibatan seluruh anggota masyarakat dalam upaya mendukung kemajuan pariwisata di desanya. Sebagian potensi lokal di sekitar Sungai Maron belum dimanfaatkan dengan optimal, seperti buah kelapa padahal jumlahnya cukup melimpah. Selain itu, keterlibatan para ibu dalam pengembangan wisata Sungai Maron juga belum optimal sebagaimana keterlibatan para laki-laki. Tujuan penelitian untuk meningkatkan minat wirausaha para ibu Pokdarwis Sungai Maron dengan potensi lokal. Jenis penelitian berupa eksperimen dengan rancangan penelitian one-group pretest-posttest design. Penelitian dilaksanakan pada bulan Agustus 2023. Sampel penelitian berupa 30 orang ibu-ibu pokdarwis Sungai Maron dengan usia rata-rata 38,3 tahun (SD+11,92). Pengambilan data dengan Skala Minat Kewirausahaan (Rel=0,876) yang dilakukan sebelum pelatihan (Pretest) dan sesudah pelatihan (Posttest). Analisis data dengan kuantitatif deskriptif dan statistik inferensial dengan teknik Wilcoxon Signed Rank Test. Hasil analisis menunjukkan ada peningkatan nilai rata-rata minat wirausaha para ibu setelah mengikuti pelatihan (Pretest 98,9 dan Posttest 103,2) dengan p=0,000 (p<0,05). Hasil penelitian menunjukkan bahwa pelatihan pemanfatan potensi lokal dapat meningkatkan minat wirausaha para ibu Pokdarwis Sungai Maron.
Current research status and future prospects of NLRP3 inflammasome in cardiovascular diseases: a bibliometric and visualization analysis
Authors: Miao Meiqi , Yang Yuanyuan , Dai Hailong 
Published: July 2024

BackgroundCardiovascular disease (CVD) is a leading cause of global mortality, with atherosclerosis (AS) contributing to its pathological basis. Inflammation plays a critical role in the pathophysiological process of AS, and the NOD-like receptor protein 3 (NLRP3) inflammasome has been extensively studied in this context. This study aimed to analyze the research status of the NLRP3 inflammasome in cardiovascular disease and provide research directions for further exploration in this field.MethodsUsing the “Bibliometrix” and “CiteSpace” software, a total of 516 articles were retrieved from the Web of Science (WoS) database published between 2012 and 2023. The search query used the keywords “[“CVD” OR “cardiovascular disease”] AND [“NLRP3 inflammasome “OR “NLRP3”]”. Visual analysis was performed on authors, countries, institutions, journal sources, keywords, references, and future trends.ResultsA total of 516 English articles were retrieved, showing an overall upward trend in annual publication volume with slight fluctuations. China, the United States, and Europe were the countries and regions with the highest number of published articles. Among them, China had the highest article count (170), while the United States had the highest citation count (18,664), centrality score (0.43), and h-index (90), indicating its influential role in this research area. These countries also possessed elite institutions, professional researchers, and high-impact journals, making them leading contributors in this field. The main pathogenic mechanisms of the NLRP3 inflammasome in CVD were identified as “oxidative stress”, “pyroptosis”, and “inflammation”. The most frequently studied signaling pathways included “NF-κB”, “IL-1”, and “C-reactive protein”. The most studied disease types were coronary heart disease, atherosclerosis, metabolic syndrome, and myocardial infarction. Additionally, research on the correlation between cholesterol markers and inflammatory indicators associated with NLRP3 inflammasome in CVD risk assessment has gained significant momentum, with the main mechanism being NLRP3/IL-6/hs-CRP and cholesterol lipoproteins emerging as a major keyword in this context.ConclusionThis study provides valuable insights into the research hotspots and emerging trends of the NLRP3 inflammasome in cardiovascular disease. The findings offer guidance for researchers and scholars in this field and facilitate the exploration of new research directions.
Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study
Authors: Ali Shafaqat , Al-Yafeai Zaki , Hossain Md. Ismail , Bhuiyan Md. Shenuarin , Duhan Sanchit , Aishwarya Richa , Goeders Nicholas E. , Bhuiyan Md. Mostafizur Rahman , Conrad Steven A. , Vanchiere John A. , Orr A. Wayne , Kevil Christopher G. , Bhuiyan Mohammad Alfrad Nobel 
Published: July 2024

BackgroundPeripheral artery disease (PAD) is on the rise worldwide, ranking as the third leading cause of atherosclerosis-related morbidity; much less is known about its trends in hospitalizations among methamphetamine and cocaine users.ObjectivesWe aim to evaluate the overall trend in the prevalence of hospital admission for PAD with or without the use of stimulant abuse (methamphetamine and cocaine) across the United States. Additionally, we evaluated the PAD-related hospitalizations trend stratified by age, race, sex, and geographic location.MethodsWe used the National Inpatient Sample (NIS) database from 2008 to 2020. The Cochran Armitage trend test was used to compare the trend between groups. Multivariate logistic regression was used to examine adjusted odds for PAD and CLI hospitalizations among methamphetamine and cocaine users.ResultsBetween 2008 and 2020, PAD-related hospitalizations showed an increasing trend in Hispanics, African Americans, and western states, while a decreasing trend in southern and Midwestern states (p-trend &lt;0.05). Among methamphetamine users, an overall increasing trend was observed in men, women, western, southern, and midwestern states (p-trend &lt;0.05). However, among cocaine users, PAD-related hospitalization increased significantly for White, African American, age group &gt;64 years, southern and western states (p-trend &lt;0.05). Overall, CLI-related hospitalizations showed an encouraging decreasing trend in men and women, age group &gt;64 years, and CLI-related amputations declined for women, White patient population, age group &gt;40, and all regions (p-trend &lt;0.05). However, among methamphetamine users, a significantly increasing trend in CLI-related hospitalization was seen in men, women, White &amp; Hispanic population, age group 26–45, western, southern, and midwestern regions.ConclusionsThere was an increasing trend in PAD-related hospitalizations among methamphetamine and cocaine users for both males and females. Although an overall decreasing trend in CLI-related hospitalization was observed for both genders, an up-trend in CLI was seen among methamphetamine users. The upward trends were more prominent for White, Hispanic &amp; African Americans, and southern and western states, highlighting racial and geographic variations over the study period.
Arthritis increases the risk of erectile dysfunction: Results from the NHANES 2001-2004
Authors: Liu Changjin , Lei Qiming , Li Jianwei , Liu Weihui 
Published: July 2024

ObjectiveThis study assessed the association between erectile dysfunction (ED) and arthritis.MethodsWeighted logistic regression and subgroup analyses were used to investigate the association between arthritis incidence and ED among participants in the 2001–2004 National Health and Nutrition Examination Survey database.ResultsAmong the participants, 27.8% and 18.5% had a self-reported history of ED and arthritis, respectively. ED was associated with arthritis (odds ratio [OR]=4.00; 95% confidence interval [CI]: 3.20–4.99; p&lt;0.001], which remained significant after adjustment (OR=1.42, 95% CI: 1.00–1.96; p&lt;0.001). Stratified by type of arthritis, after full adjustment, osteoarthritis remained significant (OR=1.11; 95% CI: 1.03–1.20; p=0.017), and rheumatoid arthritis (OR=1.03, 95% CI: 0.93–1.13; p= 0.5) and other arthritis (OR=1.04, 95% CI: 0.98–1.11; p=0.2) were not significantly correlated with ED. Multiple inference analyses confirmed the robustness of the results.ConclusionOur study showed that arthritis was strongly associated with ED. There is an urgent need to raise awareness and conduct additional research on the reasons behind this association in order to implement more scientific and rational treatment programs for patients with ED and arthritis.
Case report: tumefactive demyelinating lesions after the second cycle of alemtuzumab in multiple sclerosis; immune cell profile and biomarkers
Authors: Rabaneda-Lombarte Neus , Teniente-Serra Aina , Massuet-Vilamajó Anna , Ramo-Tello Cristina , Presas-Rodríguez Silvia 
Published: July 2024

ObjectiveWe present a case of multiple tumefactive demyelinating lesions (TDLs) emerging 24 months after the second cycle of alemtuzumab treatment.MethodsA woman with relapsing-remitting multiple sclerosis (MS) discontinued fingolimod treatment due to gestational desire, which resulted in a severe disease exacerbation. Alemtuzumab was initiated, accompanied by regular clinical, radiological, and immunological monitoring.ResultsShe relapsed prior to the second cycle, exhibiting 12 T1Gd+ lesions, and peripheral blood showed an increase in B-cells and a decrease in T-cells. At 24 months following the second cycle, she developed cognitive impairment and multiple T1Gd+ lesions, including TDLs, were evident on the brain MRI. We found not only an increase in B-cells but also in Th1 central memory cells. Th1/Th17 cells increased 3 months before the detection of TDLs.ConclusionsTDLs can appear 24 months after the second cycle of alemtuzumab treatment in MS. The increase in Th1/Th17 cells could be a candidate biomarker for TDLs in alemtuzumab-treated MS patients.