bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicenter retrospective analysis regarding the clinical manifestations and treatment results in patients with hairy cell leukemia: twenty‐four year Turkish experience in cladribine therapy
Authors: Hacioglu Sibel , Bilen Yusuf , Eser Ali , Sivgin Serdar , Gurkan Emel , Yildirim Rahsan , Aydogdu Ismet , Dogu Mehmet Hilmi , Yilmaz Mehmet , Kayikci Omur , Tombak Anil , Kuku Irfan , Celebi Harika , Akay Meltem Olga , Esen Ramazan , Korkmaz Serdal , Keskin Ali 
Published: November 2014

AbstractIn this multicenter retrospective analysis, we aimed to present clinical, laboratory and treatment results of 94 patients with Hairy cell leukemia diagnosed in 13 centers between 1990 and 2014. Sixty‐six of the patients were males and 28 were females, with a median age of 55. Splenomegaly was present in 93.5% of cases at diagnosis. The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis. Most of the patients with an indication for treatment were treated with cladribine as first‐line treatment. Total and complete response of cladribine was 97.3% and 80.7%. The relapse rate after cladribine was 16.6%, and treatment related mortality was 2.5%. Most preferred therapy (95%) was again cladribine at second‐line, and third line with CR rate of 68.4% and 66.6%, respectively. The 28‐month median OS was 91.7% in all patients and 25‐month median OS 96% for patients who were given cladribine as first‐line therapy. In conclusion, the first multicenter retrospective Turkish study where patients with HCL were followed up for a long period has revealed demographic characteristics of patients with HCL, and confirmed that cladribine treatment might be safe and effective in a relatively large series of the Turkish study population. Copyright © 2014 John Wiley & Sons, Ltd.
The combination of bortezomib with enzastaurin or lenalidomide enhances cytotoxicity in follicular and mantle cell lymphoma cell lines
Authors: Cosenza Maria , Civallero Monica , Pozzi Samantha , Marcheselli Luigi , Bari Alessia , Sacchi Stefano 
Published: November 2014

AbstractWe analyzed the combination of a proteasome inhibitor (bortezomib) with enzastaurin (PKC/AKT‐inhibitor) or lenalidomide (immunomodulatory agent) for the inhibition of proliferation and induction of apoptosis in B‐cell lymphoma cell lines and primary malignant cells. The effects of bortezomib, enzastaurin or lenalidomide, alone or in combinations, on cell viability and apoptosis were evaluated using the Cell Proliferation Kit and flow cytometry analysis. The interaction between drugs was examined by the Chou–Talalay method. Cell cycle analysis was performed by flow cytometry. The PI3K/AKT, PKC and MAPK/ERK signaling pathways were analyzed using western blot. Bortezomib with either enzastaurin or lenalidomide synergistically induced anti‐proliferative and pro‐apoptotic effects in B‐cell lymphoma cells, even in the presence of the bone marrow microenvironment. The direct cytotoxicity is mediated by signaling events involving the PI3K/AKT, PKC and MAPK/ERK pathways leading to cell death. The significant increase of apoptosis was mediated by an increased ratio of pro‐apoptotic proteins (Bax, Bad and Bim) to anti‐apoptotic proteins (Bcl‐2, Bcl‐xL and Mcl‐1), triggering the cleavage of caspases ‐3, ‐9, ‐8 and PARP. Further evaluation of the combination of bortezomib with enzastaurin or lenalidomide for the treatment of B‐cell lymphoma is warranted, with the goal to improve the quality of life and survival of patients. Copyright © 2014 John Wiley & Sons, Ltd.
Redesigning a Ministry of Health's organizational structure: exploring implementation challenges through Botswana's experiences
Authors: Seitio‐Kgokgwe Onalenna , Gauld Robin D. C. , Hill Philip C. , Barnett Pauline 
Published: November 2014

SummaryIntroductionThe Botswana's Ministry of Health redesigned and adopted a new organizational structure in 2005, which was poorly implemented. This article explores factors that influenced the implementation of this organizational structure.MethodsThis article draws from data collected through in‐depth interviews with 54 purposively selected key informants comprising policy makers, senior managers and staff of the Ministry of Health (N = 40) and senior officers from various stakeholder organizations (N = 14).FindingsParticipants generally felt that the review of the Ministry of Health organizational structure was important. The previous structure was considered obsolete with fragmented functions that limited the overall performance of the health system. The new organizational structure was viewed to be aligned to current national priorities with potential to positively influence performance. Some key weaknesses identified included lack of consultation and information sharing with workers during the restructuring process, which affected the understanding of their new roles, failure to mobilize key resources to support implementation of the new structure and inadequate monitoring of the implementation process.ConclusionRedesigning an organizational structure is a major change. There is a need for effective and sustained leadership to plan, direct, coordinate, monitor and evaluate the implementation phase of the reform. Copyright © 2014 John Wiley & Sons, Ltd.
Structure and anterior regeneration of musculature and nervous system in Cirratulus cf. cirratus (Cirratulidae, Annelida)
Authors: Weidhase Michael , Bleidorn Christoph , Helm Conrad 
Published: November 2014

ABSTRACTCover illustration. Cirratulidae are a family of marine sedentary annelids with a remarkable regenerative ability. In this issue of the Journal of Morphology,Weidhase et al. (pp. 1418–1430, 10.1002/jmor.20316) investigated the structure of musculature and nervous system in intact and anterior regenerating individuals of Cirratulus cf. cirratus using confocal laser‐scanning microscopy. Additionally, implications for general regeneration patterns in annelids were discussed. The cover image is a depth coded confocal maximum projection of the musculature of the anterior end in lateral view, showing the two layers of the body wall musculature and further muscle fibers of the parapodia, the tentacles, and the mouth opening.
It pays to have an eye for emotions: Emotion recognition ability indirectly predicts annual income
Authors: Momm Tassilo , Blickle Gerhard , Liu Yongmei , Wihler Andreas , Kholin Mareike , Menges Jochen I. 
Published: November 2014

SummaryThis study integrates the emotion and social influence literatures to examine how emotion recognition ability (ERA) relates to annual income. In a sample of 142 employee–peer–supervisor triads from a broad range of jobs and organizations, we find that people's level of ERA indirectly relates to how much they earn per year. The relationship between ERA and annual income is mediated sequentially through political skill and interpersonal facilitation. The results imply that emotional abilities allow people not only to process affect‐laden information effectively but also to use this information to successfully navigate the social world of organizations in the pursuit of prosperity. Copyright © 2014 John Wiley & Sons, Ltd.
Great auricular nerve preservation in parotid gland surgery: Long‐term outcomes
Authors: Grammatica Alberto , Perotti Pietro , Mancini Francesco , Bozzola Anna , Piazza Cesare , Nicolai Piero , Redaelli de Zinis Luca Oscar 
Published: November 2014

Objectives/HypothesisTo assess sensory outcomes and quality of life (QoL) in two groups of patients with and without great auricular nerve (GAN) preservation during parotidectomy.Study DesignRetrospective chart review.MethodsThe posterior branch of the GAN was preserved in 42 patients (group A) and sacrificed in 13 (group B). Tactile, heat, and cold sensitivities were investigated by dividing GAN territory into seven areas. Comparisons between operated (OS) and nonoperated sides (NS) within each group, and between the OS of the two groups were made. The QoL questionnaire was administered.ResultsIn group A, normal tactile, heat, and cold sensitivities ranged from 16.7% to 66.7%, 11.9% to 73.8%, and 21.4% to 81%, respectively, in different OS areas. Significant differences between OS and NS were found, except for the preauricular superior area. In group B, normal tactile, heat, and cold sensitivities ranged from 0% to 61.5%, 0% to 53.8%, and 7.7% to 76.9%, respectively, in different OS areas. Significant differences between OS and NS were found except for the preauricular superior (tactile sensitivity), and preauricular superior and helix/concha areas (cold sensitivity). Comparing the OS tactile and thermic sensitivities between the two groups, only the lobule area showed differences. The preauricular inferior area was different only for heat. The QoL questionnaire showed different hypoesthesia extension between the two groups. All other items were comparable.ConclusionsSensory deficits are commonly reported despite GAN preservation. Lobule and preauricular inferior areas showed differences in terms of tactile and thermic sensitivities, with better outcomes in group A. QoL seems tolerable despite GAN sacrifice.Level of Evidence4 Laryngoscope, 125:1107–1112, 2015
Targeted Delivery of Vaccine to Dendritic Cells by Chitosan Nanoparticles Conjugated with a Targeting Peptide Ligand Selected by Phage Display Technique
Authors: Jung Su‐Na , Kang Sang‐Kee , Yeo Guen‐Hye , Li Hai‐Ying , Jiang Tao , Nah Jae‐Woon , Bok Jin‐Duck , Cho Chong‐Su , Choi Yun‐Jaie 
Published: November 2014

AbstractThe paper presents a novel dendritic cells (DC)‐targeting peptide, TPAFRYS (TP) identified by phage display technique and conjugated to chitosan in order to develop an efficient DC‐targeting vaccine delivery carrier. TP‐conjugated chitosan nanoparticles (TPC‐NPs) were prepared with ovalbumin (OVA) as a model vaccine by ionic gelation. Flow cytometry and immunocytochemistry studies demonstrated the higher targeting ability of TPC‐NPs to DCs in compared to chitosan NPs. Moreover, TPC‐NPs exhibited higher targeting specificity in DCs than macrophage and myoblasts. Furthermore, immunization of mice with OVA‐loaded TPC‐NPs enhanced OVA‐specific serum IgG and IgG isotype antibodies production. Thus, DC‐targeting strategy demonstrates a potential approach to enhance the effectiveness of vaccines.
POCS‐based reconstruction of multiplexed sensitivity encoded MRI (POCSMUSE): A general algorithm for reducing motion‐related artifacts
Authors: Chu Mei‐Lan , Chang Hing‐Chiu , Chung Hsiao‐Wen , Truong Trong‐Kha , Bashir Mustafa R. , Chen Nan‐kuei 
Published: November 2014

PurposeA projection onto convex sets reconstruction of multiplexed sensitivity encoded MRI (POCSMUSE) is developed to reduce motion‐related artifacts, including respiration artifacts in abdominal imaging and aliasing artifacts in interleaved diffusion‐weighted imaging.TheoryImages with reduced artifacts are reconstructed with an iterative projection onto convex sets (POCS) procedure that uses the coil sensitivity profile as a constraint. This method can be applied to data obtained with different pulse sequences and k‐space trajectories. In addition, various constraints can be incorporated to stabilize the reconstruction of ill‐conditioned matrices.MethodsThe POCSMUSE technique was applied to abdominal fast spin‐echo imaging data, and its effectiveness in respiratory‐triggered scans was evaluated. The POCSMUSE method was also applied to reduce aliasing artifacts due to shot‐to‐shot phase variations in interleaved diffusion‐weighted imaging data corresponding to different k‐space trajectories and matrix condition numbers.ResultsExperimental results show that the POCSMUSE technique can effectively reduce motion‐related artifacts in data obtained with different pulse sequences, k‐space trajectories and contrasts.ConclusionPOCSMUSE is a general post‐processing algorithm for reduction of motion‐related artifacts. It is compatible with different pulse sequences, and can also be used to further reduce residual artifacts in data produced by existing motion artifact reduction methods. Magn Reson Med 74:1336–1348, 2015. © 2014 Wiley Periodicals, Inc.
Efficient production of hyperpolarized bicarbonate by chemical reaction on a DNP precursor to measure pH
Authors: Ghosh Rajat K. , Kadlecek Stephen J. , Pourfathi Mehrdad , Rizi Rahim R. 
Published: November 2014

PurposeTo produce hyperpolarized bicarbonate indirectly via chemical reaction from a hyperpolarized precursor and utilize it for the simultaneous regional measurement of metabolism and pH.MethodsAlpha keto carboxylic acids are first hyperpolarized by dissolution dynamic nuclear polarization (DNP). These precursor molecules are rapidly reacted with hydrogen peroxide (H2O2) to decarboxylate the species, resulting in new target molecules. Unreacted H2O2 is removed from the system by reaction with sulfite. Interrogation of the ratio of dissolved carbon dioxide (CO2) to bicarbonate can be used to determine pH.ResultsConversion of hyperpolarized alpha keto acids to bicarbonate and CO2 results in a minimal loss of the spin order. The reaction can be conducted to completion within seconds and preserves the nuclear spin polarization.ConclusionThrough a rapid chemical reaction, we can conserve the nuclear spin order of a DNP precursor to generate multiple hyperpolarized bioprobes otherwise unamenable to polarization. This indirect technique for the production of hyperpolarized agents can be applied to different precursor compounds to generate additional novel probes. Magn Reson Med 74:1406–1413, 2015. © 2014 Wiley Periodicals, Inc.
A 9‐year, bidirectional prospective analysis of depressive symptoms and adiposity: The African American Health Study
Authors: Hawkins Misty A.W. , Miller Douglas K. , Stewart Jesse C. 
Published: November 2014

ObjectiveDepression may be a predictor and consequence of obesity. However, available evidence for racial minorities has been inconsistent, and more prospective studies are needed. Thus, this study's objective was to examine whether depressive symptom severity is a predictor and/or consequence of total adiposity over a 9‐year period in a representative sample of late middle‐aged African‐Americans.MethodsA total of 410 participants (aged 49–65 years; baseline) in the prospective cohort African American Health study were examined. Depressive symptom severity was assessed with the Center for Epidemiologic Studies‐Depression Scale (CES‐D). Total body fat percent (BF%) and body mass index (BMI; kg/m2) were assessed. Structural equation models were tested.ResultsAll model fit statistics, other than χ2, indicated good fit (RMSEA ≤ 0.058, SRMR ≤ 0.052, CFI ≥ 0.95). Baseline CES‐D did not predict 9‐year changes in BF% (β = −0.01, P = 0.78) or BMI (β = −0.01, P = 0.77). Baseline BF% (β = 0.05, P = 0.39) and BMI (β = 0.08, P = 0.095) did not predict 9‐year change in CES‐D.ConclusionsDepressive symptom severity was not a predictor or consequence of excess total adiposity in late middle‐aged African‐American adults. Including a depression module in obesity prevention and treatment programs specifically designed for late middle‐aged African‐Americans may not have a beneficial effect on obesity outcomes.
A Room of One's Own: Highly Educated Migrants' Strategies for Creating a Home in Guangzhou
Authors: Suda Kimiko 
Published: November 2014

AbstractHighly educated rural‐to‐urban migrants living within China's first‐tier cities – known as ‘ants’ (yizu) – employ a number of different everyday strategies for creating a home in the face of structural obstacles. This article discusses such strategies in the city of Guangzhou by extending Martina Löw's (2001) concept of the constitution of urban space. Different types of migrants' strategies and the transient nature of these migrants' homes are presented against the background of current Chinese debates on social stratification, social mobility, and access to urban space. The analysis is based on 30 qualitative interviews with college graduates living in urban villages (chengzhongcun), in addition to the results of field research. Copyright © 2014 John Wiley & Sons, Ltd.
Electronic properties of MoS2/h‐BN heterostructures: Impact of dopants and impurities
Authors: Gillen Roland , Robertson John , Maultzsch Janina 
Published: November 2014

AbstractWe report density functional theory calculations of the electronic properties of doped heterostructures of monolayer molybdenum disulphide and hexagonal boron nitride (h‐BN). Extending on a recent study, we investigate the effect of doping the h‐BN layer on the electronic structure of the MoS2 subsystem by a number of impurites. We consider the intrinsic n‐type dopants S and Mo, the p‐type dopant Mg, and interstitial K and Mn atoms. Magnesium and molybdenum substitutional impurities induce tails of occupied defect states into the band gap of the compound that reach up to the conduction band minimum of MoS2. This suggests easy charge transfer between the layers in these cases. Additionally, the d‐electrons in the studied transition metal impurities induce localized magnetic momenta into the MoS2 subsystem, which might be exploited in spintronics applications. Our results contribute to the understanding of the interaction of MoS2 in vertical heterostructures with nearby impurities and offer insights into possible origins of intrinsic doping of experimental samples of MoS2.
The Relationship Between Perceived Stress and Telomere Length: A Meta‐analysis
Authors: Schutte Nicola S. , Malouff John M. 
Published: November 2014

AbstractTelomeres protect the ends of chromosomes, and short telomere length is associated with poor health and mortality. This study reports a meta‐analytic investigation of the relationship between perceived stress and telomere length, including results from eight studies with a total of 1143 participants. A meta‐analytic effect size of r = −0.25, p < 0.001, indicated that higher levels of perceived stress were associated with shorter telomere length. Examination of the studies for moderators of effect size identified some significant moderators, such as a difference in effect sizes between samples comprised of only women and mixed‐sex samples. These results are only suggestive as they are based on a small set of studies, and funnel plot analyses indicated a publication bias. A significant relationship between more perceived stress and shorter telomere length is consistent with theoretical frameworks positing that stress induces physiological changes that result in shortened telomeres. Copyright © 2014 John Wiley & Sons, Ltd.
Effect of Interpersonal and Cognitive Stressors on Habituation and the Utility of Heart Rate Variability to Measure Habituation
Authors: Feda Denise M. , Roemmich James N. 
Published: November 2014

AbstractHabituation is a decrease in responding to a repeated stimulus. Operant responding and salivation measure habituation in eating behaviour research. Stress may increase eating by acting as a distractor, yielding spontaneous recovery and prolonging responding for food. Our research tested differences in the ability of cognitive and interpersonal stressors to recover responding for food. We also tested heart rate variability (HRV) as a measure of habituation. Twenty women worked for portions of macaroni and cheese for 15 trials on three separate laboratory visits. Between the 12th and 13th trial, one of three different stressor types (speech, stroop and subtraction) was presented during each visit. HRV was measured continuously throughout the laboratory visits. Responding for food declined across the 12 trials with no difference in rate of habituation by visit (p > 0.8) There was no difference between stressor type in the magnitude of spontaneous recovery after each stressor (p > 0.8). Rates of habituation of HRV variables correlated (p < 0.02) with the rate of operant responding habituation. Cognitive and interpersonal stressors do not differ in their ability to recover reduced responding for food. HRV variables may measure habituation to food similar to operant responding. Copyright © 2014 John Wiley & Sons, Ltd.
Physiological, Perceptual and Psychological Responses of Career versus Volunteer Firefighters to Live‐fire Training Drills
Authors: Petruzzello Steven J. , Poh Paula Y.S. , Greenlee Tina A. , Goldstein Eric , Horn Gavin P. , Smith Denise L. 
Published: November 2014

AbstractA primary objective of the present study was to examine the effect of short‐term live‐fire firefighting activities on key physiological, perceptual and psychological variables and whether occupational status influenced these responses. It was also of interest to examine whether individual difference factors differentiated the occupational status groups and if so, whether such individual difference factors influenced perceptual and psychological responses to firefighting activities. Male firefighters (n = 52 career, n = 53 volunteer firefighters) participated in 18 min of simulated firefighting activity in a training structure that contained live fires. Measures of heart rate (HR) and Tcore were obtained before and after firefighting activities along with perceptions of thermal sensations, exertion, respiratory distress and affect. Firefighting activities resulted in significant elevations in HR and Tcore, whereas thermal sensations, respiratory distress, exertion and affect all showed significant and sizable changes reflecting greater distress and dysphoria. Occupational status and individual difference factors accounted for some of this negative change. The findings replicate and extend previous work by demonstrating the influence of occupational status and individual difference factors in the psychological responses to firefighting activity. Copyright © 2014 John Wiley & Sons, Ltd.
Protein‐based functional nanomaterial design for bioengineering applications
Authors: Desai Malav S. , Lee Seung‐Wuk 
Published: November 2014

In this review article, we describe recent progress in the field of protein‐based bionanomaterial design with focus on the four well‐characterized proteins: mammalian elastin and collagen, and insect‐derived silk and resilin. These proteins are important structural components and understanding their physical and biochemical properties has allowed us to not only replicate them but also create novel smart materials. The ‘smart’ properties of a material include its ability to self‐assemble, respond to stimuli, and/or promote cell interactions. Such properties can be attributed to unique structural modules from elastin, collagen, silk, and resilin as well as functional modules identified from other proteins directly or using display techniques such as phage display. Thus, the goal of this article is to not only emphasize the types of protein‐based peptide modules and their uses but also encourage and inspire the reader to create new toolsets of smart polypeptides to overcome their challenges. WIREs Nanomed Nanobiotechnol 2015, 7:69–97. doi: 10.1002/wnan.1303This article is categorized under:

Implantable Materials and Surgical Technologies > Nanomaterials and Implants
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Biology-Inspired Nanomaterials > Protein and Virus-Based Structures