bluuebunny/crossref_metadata_2025_split huggingface dataset:
A influência do cronotipo e da qualidade do sono na frequência de treinamento na academia
Authors: Siviero Rodrigo , Braga Gabriella , Esteves Andrea 
Published: October 2015

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><span style="font-size: 12.0pt; line-height: 200%; font-family: ";Times New Roman";,serif;">A partir do aumento do número de indivíduos frequentadores de academia nos últimos anos, o aprimoramento entre os horários para a realização de exercícios físicos juntamente com o cronotipo pode ser fundamental para o aumento da motivação diária e melhora das respostas fisiológicas do corpo. Assim, o objetivo do estudo foi analisar a relação entre cronotipo, sonolência e qualidade do sono com horários e frequência de treinamento físico em uma academia da cidade de Limeira. Para isso, 100 frequentadores de uma academia da cidade de Limeira entre 14 e 65 anos, de ambos os sexos, foram avaliados utilizando questionários para determinar o cronotipo, sonolência diurna excessiva e a qualidade do sono. Para controlar a frequência de alunos na academia foi utilizado o banco de dados do Sistema Integrado de Informação da academia (horários de acesso dos alunos). Os resultados demonstraram uma associação significativa entre o cronotipo vespertino e o horário de treinamento em seu período correspondente (noite) (χ² (1) = 12,84, <em>p</em> = 0,001), ao passo que os indivíduos matutinos não apresentaram um padrão de horário para o seu treinamento. Não houve relação entre a frequência semanal na academia e o cronotipo (p = 0.489). A qualidade do sono e a sonolência (χ² (1) = 2,31 , <em>p</em> = 0,195) não demonstraram associação com o treinamento em período correspondente ao cronotipo. Dessa forma, os resultados sugerem que<span style="color: red;"> </span>a qualidade do sono não influenciou na frequência da prática do exercício físico na academia, no entanto, os indivíduos que apresentaram cronotipo vespertino tiveram maior adesão em realizar seu treinamento no período correspondente ao seu cronotipo.</span></p>
Adequacy of diagnostic tests and surgical management of symptomatic invasive lobular carcinoma of the breast
Authors: Hadjiminas DJ , Zacharioudakis KE , Tasoulis MK , Hu JCC , Lanitis S , Bright-Thomas R , Dimopoulos NG , Hornzee G , Cunningham DA , Cleator SJ , Al Mufti R 
Published: October 2015

Introduction Invasive lobular carcinoma (ILC) presents diagnostic and therapeutic challenges as it produces subtle radiological changes. It has been suggested that it is not suitable for breast conserving surgery (BCS). The aim of this study was to ascertain the diagnostic adequacy of modern mammography and ultrasonography in the context of a fast track symptomatic diagnostic clinic in the UK. It also sought to compare the mastectomy, re-excision and BCS rates for ILC with those for invasive ductal carcinoma (IDC). Methods A retrospective analysis of prospectively collected data was carried out on all new symptomatic cancers presenting to the one-stop diagnostic clinic of a single breast unit between 1998 and 2007. Results Compared with IDC, ILC was significantly larger at presentation (46mm vs 25mm), needed re-excision after BCS more often (38.8% vs 22.3%) and required mastectomy more frequently (58.8% vs 40.8%). Although mammography performs poorly in diagnosing ILC compared with IDC, when combined with ultrasonography, sensitivity of the combined imaging was not significantly different between these two histological types. Conclusions Provided ultrasonography is performed, standard radiological imaging is adequate for initial diagnosis of symptomatically presenting ILC but some additional preoperative workup should clearly be employed to reduce the higher number of reoperations for this histological type.
Acute surgical unit safely reduces unnecessary after-hours cholecystectomy
Authors: Suhardja TS , Bae L , Seah EZ , Cashin P , Croagh DG 
Published: October 2015

Introduction The acute surgical model has been trialled in several institutions with mixed results. The aim of this study was to determine whether the acute surgical model provides better outcomes for patients with acute biliary presentation, compared with the traditional emergency surgery model of care. Methods A retrospective review was carried out of patients who were admitted for management of acute biliary presentation, before and after the establishment of an acute surgical unit (ASU). Outcomes measured were time to operation, operating time, after-hours operation (6pm – 8am), length of stay and surgical complications. Results A total of 342 patients presented with acute biliary symptoms and were managed operatively. The median time to operation was significantly reduced in the ASU group (32.4 vs 25.4 hours, p=0.047), as were the proportion of operations performed after hours (19.5% vs 2.5%, p<0.001) and the median length of stay (4 vs 3 days, p<0.001). The median operating time, rate of conversion to open cholecystectomy and wound infection rates remained similar. Conclusions Implementation of an ASU can lead to objective differences in outcomes for patients who present with acute cholecystitis. In our study, the ASU significantly reduced time to operation, the number of operations performed after hours and length of stay.
An author’s guide to submission, revision and rejection
Authors: Shah Jyoti 
Published: October 2015

‘Continuous effort, not strength or intelligence, is the key to understanding our potential.’ Winston Churchill The sting of rejection is nasty. However, when you get that letter (which you will), remember you will be in esteemed company. Many of us would like to publish in Science or Nature but what better revenge when they reject you than a Nobel Prize! This is exactly what happened to Hans Krebs, the biochemist who won the Nobel Prize in 1953 for discovering the citric acid cycle, commonly known as the Krebs cycle. Krebs submitted his findings to Nature but was faced with rejection. Never has Frank Sinatra’s famous quote been truer: ‘The best revenge is massive success.’ Nature has admitted to many other such faux pas in its publishing history and it is not unique in its misjudgements. Publishing is a game of risk-taking behaviour and strategy. Authors must convince editors and referees that their work is worthy of publishing. When journals do not publish this work, authors must remember the value of their manuscript and persist in finding it another home. JYOTI SHAH Commissioning Editor
Pier Paolo Pasolini and the construction of masculinity in Italian fashion
Authors: Colaiacomo Paola 
Published: October 2015

Abstract
In this article, the study of fashion is engaged in from a transdisciplinary perspective, at the crossroads of fashion and literature. In his novels, movies, essays and short stories, Pier Paolo Pasolini brought to the public’s attention the sub-proletarian bodies of the male youth of post-war Italy, and of Rome in particular. As yet, the Roman ragazzi had no figure in the readers’, or spectators’, minds, and this fact gave him the liberty to scrutinize their bodies, down to the very rags which covered them, without having to dispel preconceived expectations. Focalized, the gap between body and dress becomes with him an interzone, an in-between space where the porosity between dress, body and character is captured. More often than not, this compositional style resulted in an erotic accentuation of the character’s physicality, both in film and on the written page.
The sub-proletarian body’s final inscription in the canon of male beauty is sanctioned in our own days, when such conceptual designers as Raf Simons and Hedi Slimane, now busy in recovering the subcultural roots of their design, openly insert that body’s habit of being into the narrative of fashion. To our media-savvy eyes, not a small result.
CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function
Authors: Holmannová Drahomíra , Koláčková Martina , Kondělková Kateřina , Kuneš Pavel , Krejsek Jan , Andrýs Ctirad 
Published: October 2015

CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin‑like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of T cells to the Treg subset, upregulates indoleamine 2,3‑dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL‑10 and TGF‑β synthesis. CD200/CD200R are required for maintaining self‑tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss.
Crystal structure of crystal structure of poly{bis-[(4,4′-biphenyl-dicarboxylate-κ2O:O′)-μ-1,1′-oxy-bis-(ethane-2,1-diyl)-bis-(1H-imidazole)-κ2N:N′] zinc(II)}dihydrate, C48H48N8O12Zn2
Authors: Zhang Lai-Ping , Chen Gai-Rong 
Published: October 2015

AbstractC
Combination Therapy Of Tadalafil And Pentoxifylline In Severe Erectile Dysfunction; A Prospective Randomized Trial
Authors: Kumar Santosh , Roat Rajesh , Agrawal Swati , Jayant Kumar , Mavuduru Ravimohan S. , Kumar Shrawan 
Published: October 2015

Abstractwas to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire.Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire. Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifyl-line. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student’s unpaired t-test, paired t-test, chi square test. p-value < 0.05 was considered statistically significant.Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78.6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86.6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90.7±15.2%, group B 95.6±13.4%; p value – 0.014). We found this difference even more statistically significant in patients with severe ED (group A 72.7±47.2%, group B 132.3±54.3%; p value – 0.000). There was no significant difference in between the two groups with regards to occur-rence of side effects.Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.
The Use Of Anterolateral Thigh Flap (ALTF) For Functional Tongue Reconstruction With Postoperative Quality Of Live Evaluation
Authors: Krakowczyk Łukasz , Maciejewski Adam , Szymczyk Cezary , Wierzgoń Janusz , Półtorak Stanisław 
Published: October 2015

AbstractThe use of microsurgery for oral reconstruction of cancer patients, has become standard treatment in restoring oral function. The free anterolateral thigh flap is one of the most preferred options in reconstruction after total, subtotal or hemiresection of the tonque due to squamous cell cancer.was to present the reconstructive method using anterolateral thigh free flap with evaluation of quality of live.Clinical material includes 46 consecutive patients with tongue cancer, who underwent complex surgical treatment between 2009 and 2011. There were 36 males and 10 females and the M: F ratio was 3.6: 1. All of them were reconstructed using the anterolateral thigh free flap. The quality of life was evaluated 6 months after completing the treatment, based on postoperative functional and aesthetic status.The overall flap survival rate was 96%. Surgical complications were observed in 8 patients (17%). Donor site was closed primarly in 42 cases and in remaining 4 skin graft was required. In all 46 cases understandable speech and return to unrestricted diet mastication and swallowing were achieved. The mean follow-up period after treatment was 32 months. Analysis of aesthetic effects evaluated in 23 cases and shows generally very good results. According to average transformed scores the QOL can be characterized as excellent for >90, very good for 76-90, good for 51-75, moderate for 25-50 and bad for <25 points.Anterolateral thigh flap, with its versatility in design, long pedicle with a suitable vessel diameter, low donor site morbidity, and very good aesthetic effects, could be the ideal flap for functional tongue reconstruction.
Rare Facial Clefts
Authors: Fijałkowska Marta , Antoszewski Bogusław 
Published: October 2015

AbstractIn 1976 Dr. Paul Tessier described numeric classification for rare craniofacial clefts. He first emphasized that a fissure of the soft tissue corresponds, as a general rule, to a cleft of the bony structure. The classification, easy to understand, became widely accepted because the recording of the malformations was simple and facilitated communication between observers.was to present our own experience with treatment of patients with rare facial clefts.Our Department has 11 patients with rare craniofacial clefts under its care. This group includes 8 boys and 3 girls. The patients aged from 2 months to 18 years at the time of the first consultation.In two patients the cleft was median, in seven patients it was one-sided and in two – bilateral. The most common type of cleft was number 6, and the rarest were 2, 3, and 7. All patients underwent surgical treatment.Atypical facial clefts are rare congenital anomalies, however because of functional and aesthetic disturbances they constitute a serious medical and therapeutic problem. Facial clefts are characterized by variable clinical presentation and require individualized treatment plan.
Description Of Minimally Invasive Methods Of Treatment Of Walled-Off Pancreatic Necrosis (WOPN)- The Use Of „Step-Up Approach” In Patient With Pancreatic Necrosis
Authors: Jagielski Mateusz , Smoczyński Marian , Studniarek Michał , Adrych Krystian 
Published: October 2015

AbstractThe study presents description of treatment of patients with walled-off pancreatic necrosis (WOPN). The strategy of treatment was to extend access to necrotic areas (“step-up approach”). Applied endoscopic transmural access (transgastric) and percutaneous access (transperitoneal). The endoscopic necrosectomy under fluoroscopic guidance was repeated four times during active transluminal drainage. Endoscopic treatment with percutaneous drainage gave very beneficial clinical effects.
Passions, Pleasures, and Perceptions: Rethinking Evagrius Ponticus on Mental Representation
Authors: Gibbons Kathleen 
Published: October 2015

AbstractEvagrius Ponticus’s theory of the eight bad thoughts has often been read as indebted to Stoic ideas of mental representation. This is in part, however, a consequence of the fact that the significance of φαντασία to Plato’s own thought has only recently begun to receive adequate attention. In this paper, I explore how recent studies into Plato’s theory of passion help illuminate Evagrius’s ideas about the relationship between affect and mental representation. Interpreting Evagrius’s treatment of passion as perspectival (rather than judgmental) helps illuminate his understanding of the relationship between the ascetic and contemplative lives and his conception of selfhood.
Wer ist der Jüngling? Die Taufe des Gundaphor in den Thomasakten und der Kult des Asklepios
Authors: Leonhard Clemens 
Published: October 2015

AbstractThe Acts of Thomas relate the Apostle Thomas’ missionary journey to India and his missionary successes. The narrative tells that Thomas baptized important persons of the Indian society. The description of king Gundaphor’s baptism ends in a vision: “And when they had come up out of the water, a youth appeared to them, and he was holding a lighted taper; and the light of the lamps became pale through its light.”1 The following essay discusses the question of the identification of this literary figure of the young man in the context of similar evidence from the cult of Asclepius. It also reflects on the explanation of this figure from a methodological point of view. It analyzes the modern perception of these texts and its contribution to the understanding of the ancient liturgies of baptism and their ritual shape. While the rituals, procedures, places, and notions of the cult of Asclepius were firmly embedded in Christian world views of late antiquity and the early middle ages, the allusions to the cult of Asclepius in the Acts of Thomas rather suggest the reverse situation for that earlier epoch: The Acts of Thomas explain Christian baptism in terms of the theory of the cult of Asclepius. As it becomes difficult, furthermore, to distinguish between elements of ritual description and ritual explanation in the guise of the narrative, these observations advise caution in the use of the descriptions of the liturgies in the Acts of Thomas for reconstructions of the history of Christian baptism.
Life-threatening events in patients with pheochromocytoma
Authors: Riester Anna , Weismann Dirk , Quinkler Marcus , Lichtenauer Urs D , Sommerey Sandra , Halbritter Roland , Penning Randolph , Spitzweg Christine , Schopohl Jochen , Beuschlein Felix , Reincke Martin 
Published: October 2015

ObjectivePheochromocytomas are rare chromaffin cell-derived tumors causing paroxysmal episodes of headache, palpitation, sweating and hypertension. Life-threatening complications have been described in case reports and small series. Systematic analyses are not available. We took an opportunity of a large series to make a survey.Design and methodsWe analyzed records of patients diagnosed with pheochromocytomas in three geographically spread German referral centers between 2003 and 2012 (n=135).ResultsEleven percent of the patients (ten women, five men) required in-hospital treatment on intensive care units (ICUs) due to complications caused by unsuspected pheochromocytomas. The main reasons for ICU admission were acute catecholamine induced Tako-Tsubo cardiomyopathy (n=4), myocardial infarction (n=2), acute pulmonary edema (n=2), cerebrovascular stroke (n=2), ischemic ileus (n=1), acute renal failure (n=2), and multi organ failure (n=1). One patient required extracorporeal membrane oxygenation due to a hypertensive crisis with lung edema occurring during delivery (n=1). Two patients died of refractory shock and pheochromocytomas were found postmortem. Two patients were treated by emergency surgery. Compared to pheochromocytoma patients without life-threatening events (n=120), patients with complications had a significant larger maximal tumor diameter (7.0 vs 4.5 cm, P<0.01), higher levels of catecholamines (20- vs ninefold upper limit of normal, P<0.01), and tended to be younger (42 vs 51 years, P=0.05).ConclusionAlthough pheochromocytomas are rare, they are likely to be associated with a life-threatening situation. Clinicians have to be aware of these situations and perform a timely diagnosis.
Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu
Authors: Jeong Choongwon , Nakagome Shigeki , Di Rienzo Anna 
Published: October 2015

AbstractDespite recent advances in population genomics, much remains to be elucidated with regard to East Asian population history. The Ainu, a hunter–gatherer population of northern Japan and Sakhalin island of Russia, are thought to be key to elucidating the prehistory of Japan and the peopling of East Asia. Here, we study the genetic relationship of the Ainu with other East Asian and Siberian populations outside the Japanese archipelago using genome-wide genotyping data. We find that the Ainu represent a deep branch of East Asian diversity more basal than all present-day East Asian farmers. However, we did not find a genetic connection between the Ainu and populations of the Tibetan plateau, rejecting their long-held hypothetical connection based on Y chromosome data. Unlike all other East Asian populations investigated, the Ainu have a closer genetic relationship with northeast Siberians than with central Siberians, suggesting ancient connections among populations around the Sea of Okhotsk. We also detect a recent genetic contribution of the Ainu to nearby populations, but no evidence for reciprocal recent gene flow is observed. Whole genome sequencing of contemporary and ancient Ainu individuals will be helpful to understand the details of the deep history of East Asians.
Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in StarvingEscherichia coli
Authors: Moore Jessica M , Magnan David , Mojica Ana K , Núñez María Angélica Bravo , Bates David , Rosenberg Susan M , Hastings P J 
Published: October 2015

AbstractThe mutagenicity of DNA double-strand break repair in Escherichia coli is controlled by DNA-damage (SOS) and general (RpoS) stress responses, which let error-prone DNA polymerases participate, potentially accelerating evolution during stress. Either base substitutions and indels or genome rearrangements result. Here we discovered that most small basic proteins that compact the genome, nucleoid-associated proteins (NAPs), promote or inhibit mutagenic break repair (MBR) via different routes. Of 15 NAPs, H-NS, Fis, CspE, and CbpA were required for MBR; Dps inhibited MBR; StpA and Hha did neither; and five others were characterized previously. Three essential genes were not tested. Using multiple tests, we found the following: First, Dps, which reduces reactive oxygen species (ROS), inhibited MBR, implicating ROS in MBR. Second, CbpA promoted F′ plasmid maintenance, allowing MBR to be measured in an F′-based assay. Third, Fis was required for activation of the SOS DNA-damage response and could be substituted in MBR by SOS-induced levels of DinB error-prone DNA polymerase. Thus, Fis promoted MBR by allowing SOS activation. Fourth, H-NS represses ROS detoxifier sodB and was substituted in MBR by deletion of sodB, which was not otherwise mutagenic. We conclude that normal ROS levels promote MBR and that H-NS promotes MBR by maintaining ROS. CspE positively regulates RpoS, which is required for MBR. Four of five previously characterized NAPs promoted stress responses that enhance MBR. Hence, most NAPs affect MBR, the majority via regulatory functions. The data show that a total of six NAPs promote MBR by regulating stress responses, indicating the importance of nucleoid structure and function to the regulation of MBR and of coupling mutagenesis to stress, creating genetic diversity responsively.