bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Synthesis Conditions on the Composition, Local Structure and Electrochemical Behavior of (Cr,Fe,Mn,Co,Ni)3O4 Anode Material
Authors: Mishchenko Kseniya V. , Tyapkin Pavel Yu. , Slobodyuk Arseny B. , Kirsanova Maria A. , Kosova Nina V. 
Published: July 2024

AbstractDisordered high entropy spinels (HES) (Cr,Fe,Mn,Co,Ni)3O4 were obtained by solid‐state synthesis and co‐precipitation using various powder precursors. They were characterized by a complex of physico‐chemical methods and investigated as anode materials for lithium‐ion batteries (LIBs). According to XRD and TEM data, the materials are single‐phase. The structural characterization of the samples obtained at 773, 973, and 1273 K was determined using Raman and Mössbauer spectroscopy, and magnetic measurements. The degree of spinel inversion and lattice distortion (microstrains) decrease with increasing synthesis temperature, while the crystallite size increases. The insufficient nickel content in the samples ensures a more uniform distribution of iron cations in both sublattices, which leads to an increase in the lattice parameters and has a positive effect on the de‐/lithiation. Repeated ball‐milling of HES material, prepared by co‐precipitation, increases its specific capacity from 284 mAh g−1 to 492 mAh g−1 at a current density of 100 mA g−1 after 25 cycles. Besides, the smaller crystallite size reduces the volume changes in the materials during de‐/lithiation.
Factor‐Analytic Variance–Covariance Structures for Prediction Into a Target Population of Environments
Authors: Piepho Hans‐Peter , Williams Emlyn 
Published: July 2024

ABSTRACTFinlay–Wilkinson regression is a popular method for modeling genotype–environment interaction in plant breeding and crop variety testing. When environment is a random factor, this model may be cast as a factor‐analytic variance–covariance structure, implying a regression on random latent environmental variables. This paper reviews such models with a focus on their use in the analysis of multi‐environment trials for the purpose of making predictions in a target population of environments. We investigate the implication of random versus fixed effects assumptions, starting from basic analysis‐of‐variance models, then moving on to factor‐analytic models and considering the transition to models involving observable environmental covariates, which promise to provide more accurate and targeted predictions than models with latent environmental variables.
Water‐filtered infrared A radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours
Authors: Liu Pengyuan , Wu Jing , Chen Liting , Wu Zhenhai , Wu Yufei , Zhang Ganlu , Yu Bingqi , Zhang Beibei , Wei Nan , Shi Jinan , Zhang Chuanfeng , Lei Lan , Yu Shuhuan , Lai Jianjun , Guo Zhen , Zheng Yuli , Jing Zhao , Jiang Hao , Wang Tingxiang , Zhou Jueyi , Wu Yajun , Sun Chuan , Shen Jie , Zhang Jian , Wu Zhibing 
Published: July 2024

AbstractIntroductionThis study aimed to validate the effectiveness, safety and feasibility of water‐filtered infrared A radiation (WIRA) whole‐body hyperthermia combined with immune checkpoint inhibitor (ICI) therapy (HIT) and evaluate the real‐world clinical application prospects.MethodsThis open‐label single‐arm phase 2 clinical trial (NCT06022692) aimed to enrol advanced gastrointestinal tumour (GIT) patients with the MSS/pMMR phenotype. The patients were treated with whole‐body hyperthermia on Days 1 and 8 of each HIT cycle along with administration of tislelizumab on Day 2.ResultsBetween 1 June 2020 and 31 May 2022, 18 patients were enrolled in the study, including those with gastric cancer (n = 6), colon cancer (n = 7), rectal cancer (n = 3) and appendiceal cancer (n = 2). As of 19 May 2023, 17 of the 18 patients had died, including 14 deaths caused by tumour progression and three deaths caused by diseases other than cancer, while one patient was still undergoing follow‐up. In terms of efficacy, the median DCR was 55.6%, while the median PFS and OS were 53.5 days and 134 days, respectively. Four patients (22.2%) experienced immune‐related adverse events, and none of the patients reported grade 3 or higher irAEs. Hyperthermia was followed by an increase in the number of tumour immune‐activated cells.ConclusionsHIT can provide survival benefits in patients with GITs by activating antitumour immune function and shows good safety and feasibility.
DNA/BSA Binding and Antimicrobial Properties of Biguanide‐Cu(II) Complexes
Authors: Ballı Julide Nacaroğlu , Gungor Ozge , Kocer Ferudun , Kose Muhammet 
Published: July 2024

AbstractThe biguanide Cu(II) complexes [Cu(L1–4)2](ClO4)2 were synthesized and spectroscopic/analytical techniques were used to clarify their structures. Single crystals of complex [Cu(L4)2](ClO4)2 was obtained and its definite structure was determined by single crystal X‐ray diffraction study. The complexes [Cu(L1–4)2](ClO4)2 were screened for their FSds‐DNA interactions by using UV‐Vis absorption and fluorescence spectroscopies. The complexes [Cu(L2)2](ClO4)2 and [Cu(L3)2](ClO4)2 were shown to exhibit higher affinity for binding DNA. Examining the EB‐DNA interaction, it is believed that the complexes interact with DNA through a groove binding mechanism. The interaction of complexes with BSA were observed through the quenching of the fluorescence emission. Complexes [Cu(L2)2](ClO4)2 and [Cu(L3)2](ClO4)2 show moderate binding affinity to BSA through a static mode. Additionally, the Cu(II) complexes were screened for their antibacterial activities against various bacterial strains. Complexes showed potential antimicrobial activity against Salmonella typhimurium, Bacillus cereus, Salmonella typhimurium and S. aureus.
Synthesis, Characterization, Biological, ADMET, and Molecular Docking Studies of Transition Metal Complexes of Aminopyridine Schiff Base Derivative
Authors: Alka  , Singh Jugmendra , Kumari Pratibha , Jain Pallavi 
Published: July 2024

Abstract1,2‐diphenylethane‐1,2‐diylidene)bis(azanylylidene))bis(pyridine‐3‐thiol) ligand was synthesized by refluxing 2‐aminopyridine‐3‐thiol with benzil in 2 : 1 molar ratio. Manganese(II), Cobalt(II), Nickel(II) and Copper(II) were also synthesized using the same method. All the compounds were characterized employing various analytical and spectroscopic methods, including melting point determination, molar conductance, magnetic moment measurement, 1H‐NMR, FTIR, mass spectrometry, EPR, and UV‐Visible spectroscopy. The antimicrobial potential of ligand and its complexes was assessed against B. subtilis, S. typhi, A. flavus, and M. phaseolina using the well‐diffusion method. Gentamycin and Amphotericin B were used as standard reference drugs. The complexes revealed more potent antimicrobial action than the ligand. Molecular docking studies were performed using crystal structures of B. subtilis, and A. flavus receptor proteins. In silico studies suggested the druglikeness potential of the synthesized compounds. The Nickel(II) complex showed superior biological efficacy based on the experimental and computational results.
Evaluation of nontarget lesions in femoropopliteal disease using near‐infrared spectroscopy intravascular ultrasound imaging
Authors: Sato Yusuke , Morishita Tetsuji , Shimizu Tomohiro , Kataoka Tatsuhiro , Matsunaka Yuya , Uzui Hiroyasu , Tada Hiroshi 
Published: July 2024

AbstractBackgroundIn coronary artery disease (CAD), lipid‐core‐containing plaque (LCP) in nontarget lesions detected using near‐infrared spectroscopy intravascular ultrasound (NIRS‐IVUS) was related to increased major adverse cardiovascular events in patients with CAD. In the endovascular therapy field, few previous studies using NIRS‐IVUS revealed the presence of LCPs in severe stenotic lesions of femoropopliteal disease.AimThis study aimed to assess the plaque morphology of nontarget lesions, especially LCPs, and compare it with that of target lesions using NIRS‐IVUS in patients with femoropopliteal disease.MethodsThis single‐center prospective observational study included 14 patients who underwent endovascular therapy for FP disease. NIRS‐IVUS assessment was performed on the entire FP arterial segment. Forty‐one LCP lesions with a maximum lipid‐core burden index in any 4‐mm region (max LCBI4mm) > 100 were detected using NIRS‐IVUS. We evaluated the patient and lesion characteristics. LCP lesions were divided into the target (n = 18) and nontarget (n = 23) lesion groups for comparison.ResultsPatient characteristics were notable for advanced age (76.8 ± 6.6 years); high proportion of males (78.7%); and high incidence of hypertension (100%), dyslipidemia (78.6%), diabetes (64.3%). Regarding NIRS findings, the target lesion group exhibited a significantly smaller proportion of LCPs concerning the lesion length (25.9 ± 15.7% vs. 50.6 ± 29.2%, p = 0.002) than the nontarget lesion group. Conversely, there were no significant differences in the value of max LCBI4mm (284.4 ± 153.4 vs. 289.5 ± 113.1, p = 0.90), length of LCP lesion (9.8 ± 9.7 mm vs. 10.7 ± 6.9 mm, p = 0.74), and distribution of LCPs (p = 0.08) between the groups. In addition, the number of LCPs in the target FP artery positively correlated with max LCBI4mm in the target FP artery (r = 0.671, p = 0.008).ConclusionsNIRS‐IVUS findings demonstrated the presence of LCPs in nontarget lesions in patients with FP disease. Moreover, the abundance of LCPs in nontarget lesions was similar to that in target lesions in FP disease.
Composition and sensory properties of breads supplemented with Brewers' spent grain from three different craft beer styles
Authors: Pereira de Freitas Fabio P. , da Silva Lannes Suzana C. 
Published: July 2024

AbstractBackground and ObjectivesWhile the beer style expresses beer's diversity by its sensory properties, ingredients, production method, recipe, and history, fibrous fraction and functional properties of Brewers' spent grain (BSG) vary according to the beer style. To investigate the effects of beer style, the physicochemical and technological properties of BSG breads containing 10% of dry BSG from beers Baltic Porter (BP), India Pale Ale (IPA), and Weissbier (W) were evaluated according to their sensory quality, firmness, staling rate, crumb color and structure, proximal composition, and dietary fiber content.FindingsAll evaluated parameters of BSG breads were significantly affected, but differed according to the BSG source. All investigated BSG significantly increased the dietary fiber levels of breads, while only BP bread presented enhanced protein content.ConclusionsHigher deleterious BSG effects in bread quality were verified in IPA bread, which presented the highest dietary fiber content, while the fiber content of BP and W breads were inconsistent with bread quality.Significance and NoveltyAlthough BSG incorporation up to 10% was reported as a limit for obtaining acceptable BSG breads, beer style must also be considered because specific volume, staling rate, and acceptance of breads may be negatively affected by its fiber content.
Exploring Synthesis Strategies and Interactions between MOFs and Drugs for Controlled Drug Loading and Release, Characterizing Interactions through Advanced Techniques
Authors: Chiñas‐Rojas Lidia E. , Domínguez José E. , Herrera Luis Ángel Alfonso , González‐Jiménez Francisco E. , Colorado‐Peralta Raúl , Arenzano Altaif Jesús Antonio , Rivera Villanueva José María 
Published: July 2024

AbstractThis study explores various aspects of Metal‐Organic Frameworks (MOFs), focusing on synthesis techniques to adjust pore size and key ligands and metals for crafting carrier MOFs. It investigates MOF‐drug interactions, including hydrogen bonding, van der Waals, and electrostatic interactions, along with kinetic studies. The multifaceted applications of MOFs in drug delivery systems are elucidated. The morphology and structure of MOFs are intricately linked to synthesis methodology, impacting attributes like crystallinity, porosity, and surface area. Hydrothermal synthesis yields MOFs with high crystallinity, suitable for catalytic applications, while solvothermal synthesis generates MOFs with increased porosity, ideal for gas and liquid adsorption. Understanding MOF‐drug interactions is crucial for optimizing drug delivery, affecting charge capacity, stability, and therapeutic efficacy. Kinetic studies determine drug release rates and uniformity, vital for controlled drug delivery. Overall, comprehending drug‐MOF interactions and kinetics is essential for developing effective and controllable drug delivery systems.
A case of biopsy‐proven acute interstitial nephritis following atezolizumab‐bevacizumab treatment of advanced unresectable hepatocellular carcinoma
Authors: Patel Reema , Elghawy Omar , Gibbs Amanda , Gupta Srishti , Kaur Varinder 
Published: July 2024

AbstractBackgroundThe advent of immune checkpoint inhibitors (ICIs) represented a significant breakthrough in cancer therapy. Recently, the combined use of atezolizumab and bevacizumab was approved as first‐line treatment for unresectable hepatocellular carcinoma (HCC). Exposure to a novel and diverse spectrum of immune‐related adverse events (irAEs) has increased with the growing utilization of ICIs, however, a comprehensive understanding surrounding newer agents is still lacking. The incidence of kidney toxicities is rare but rising, often underreported due to the lack of confirmatory biopsies. Here, we present a rare case of biopsy‐proven acute interstitial nephritis (AIN) following atezolizumab‐bevacizumab treatment of advanced unresectable HCC.CaseAn 84‐year‐old male with T4N0M0 hepatocellular carcinoma was admitted after cycle 5 of atezolizumab due to decreased urine output and dysuria with a serum creatine of 4.7 mg/dL compared to a baseline of 1.3 mg/dL. To confirm the diagnosis of possible intrinsic renal injury, an ultrasound‐guided non‐focal biopsy of the left kidney was performed, revealing AIN. Potential exacerbatory medications, such as proton‐pump inhibitors, were discontinued. The patient was discharged on oral steroids with improvement in serum creatinine. Before completing the steroid taper, the patient developed pneumocystis pneumonia and eventually transitioned to hospice care.ConclusionThis case highlights the valuable role renal biopsy can play in accurately capturing irAEs and guiding appropriate management in the setting of ICI‐induced AKI. It also exemplifies important considerations for steroid treatment of irAEs in the setting of comorbidities, such as diabetes.
Probing Self‐Assembly of Ammeline in Chloroform and Aqueous Media: Interplay Between Hydrogen Bonding Diversity and Dimerization
Authors: Pamies Silvana Carina , Peruchena Nélida María , Petelski Andre Nicolai 
Published: July 2024

AbstractAmmeline (AM) is a molecule with a very low reputation in the field of supramolecular community, but with a recently proven potential both experimentally and theoretically. In this work, dispersion‐corrected density functional theory (DFT‐D) computations and molecular dynamics (MD) simulations were employed to understand the aggregation mechanism of AM in chloroform and water media. Our DFT‐D and MD analyses show that the most important interactions are those formed by the amine groups (−NH2) with both the pyridine‐type nitrogen atoms and the carbonyl groups (C=O). In the more polar solvent, the interactions between water molecules and the C=O group prevent the AM from forming more interactions with itself. Nevertheless, four types of dimers involving N−H ⋅ ⋅ ⋅ O interactions were found to exist in water solutions. The overlooked tetrel bond between endocyclic N and C atoms can also stabilize dimers in solution. Moreover, while most AM dimers are enthalpy‐driven, our results indicate that the unique DD‐AA dimer (D=donor, A=acceptor) that originates cyclic rosettes is entropy‐driven.
Second generation current conveyor based capacitorless floating memristor emulator
Authors: Kumar Navnit , Kumar Manjeet , Pandey Neeta , Minaei Shahram 
Published: July 2024

AbstractThis article offers a novel flux controlled floating memristor emulator based on second‐generation current conveyor (CCII). The floating memristor is designed using two CCIIs, one resistor, and one PMOS transistor. The presented memristor emulator does not need external capacitance. The proposed designed circuit exhibits pinch hysteresis loops in voltage–current plane up to 2 GHz frequency. The performance of the circuit under consideration is evaluated using 180 nm CMOS technology parameter by the SPICE simulator. The circuit requires a DC power supply of ±1.2 V and exhibits a power consumption of 0.766 mW. Furthermore, the resilience of the planned circuit is assessed by examining process corner fluctuation, supply voltage variation, temperature variation, and transistor size variations. In addition, a Schmitt trigger circuit and high order filters based on designed memristor are used to confirm the operation of the proposed design at high and low frequency, respectively.
Tidally influenced deposits in the Río Alías Strait connecting a marginal basin with the Mediterranean Sea (Pliocene, South‐East Spain)
Authors: Sola Fernando , Puga‐Bernabéu Ángel , Braga Juan C. 
Published: July 2024

AbstractThe Río Alías Strait developed in the Early Pliocene as a narrow marine corridor at the connection of the microtidal Mediterranean Sea and the north‐eastern margin of the Almería‐Níjar Basin in the eastern Betic Cordillera (South‐East Spain). The orientation and topography of the strait were controlled by the transpressive Carboneras and Polopos/South Cabrera fault systems. Ten sedimentary facies occur in the up to 150 m thick mixed biogenic carbonate‐terrigenous succession distinguished on the basis of their lithology, components, grain size, stratal geometries and sedimentary structures, which were observed in seven sections at well‐exposed outcrops of four sectors. The sedimentary record of the Río Alías Strait reflects the morphological constraints, which conditioned its sedimentary dynamics and facies distribution. Even in this microtidal setting, tidal current amplification through narrow constrictions produced thick accumulations of large cross‐stratified bodies up to 15 m thick formed by the opposite migration of three‐dimensional simple and compound dunes. The Río Alías Strait reconstruction shows: (1) a very narrow constriction in the central sector from which “constriction‐related deltas” (CRDs) formed in the flood downstream (westward) and ebb (upstream) directions and (2) a relatively deep depression (>65 m water depth) separating the eastern and central‐east sectors, where tidal current energy was attenuated and dunes were not generated. The closure of the strait resulted from the tectonic uplift of the antecedent upland of Sierra Cabrera at the northern side, which promoted the southward progradation of deltaic systems over the strait. The Río Alías Strait represents the only clear record of a microtidal strait in the Betic Cordillera since the Miocene. The case study presented here improves existing models on the sedimentary dynamics of ancient tidal‐dominated straits by expanding the knowledge on their spatial environment variability.
Ecological drivers of taxonomic, functional, and phylogenetic diversity of bryophytes in an oceanic island
Authors: Martins Anabela , Collart Flavien , Sim‐Sim Manuela , Patiño Jairo 
Published: July 2024

AbstractMontane oceanic islands possess unique geographic and ecological attributes, rendering them valuable for assessing patterns and drivers of alpha and beta taxonomic, functional, and phylogenetic diversity along elevational gradients. Such comparisons of diversity facets can provide insights into the mechanisms governing community assembly on islands. Herein, we aimed to characterize taxonomic, functional, and phylogenetic bryophyte diversity on Madeira Island within and across areas at varying elevations. We also assessed how these diversity facets for the alpha and beta components relate to ecological and anthropogenic factors. We estimated and compared alpha and beta taxonomic, functional, and phylogenetic diversity using 80 plots of 0.5 m × 0.5 m across the whole elevational gradient of the island. We compiled trait databases and supplemented them with our own observations. Phylogenetic information was sourced from the Moss and Liverwort Tree of Life. To assess the impact of ecological and anthropogenic factors on the three facets, we applied linear mixed‐effects models and generalized dissimilarity models to alpha‐ and beta‐diversity matrices, respectively. All facets of diversity exhibited strong correlations within both mosses and liverworts, indicating a substantial congruence when alpha and beta are analyzed separately. The bryophyte groups categorized by the growth form demonstrated contrasting patterns, aligning with their distinctive ecological requirements. While a mid‐elevation peak emerged as a common pattern across the three facets of alpha diversity, beta diversity often displayed the opposite trend. Although the relative influence of environmental factors varied depending on the diversity facet and bryophyte grouping considered, we found that alpha and beta diversity of bryophytes are more influenced by climatic factors and the predominant type of vegetation than by anthropogenic factors. In the current context of global change, these results should be interpreted with caution, but they point to the resilience of bryophytes to survive in relatively well‐preserved natural microhabitats within anthropogenic landscapes. In this study on Madeira Island, we investigated patterns and drivers of alpha and beta taxonomic, functional, and phylogenetic diversity along elevational gradients. We found that alpha and beta diversity of bryophytes are more strongly influenced by climatic factors and the predominant type of vegetation than by anthropogenic factors.
A statistical approach to assess interspecific consumptive competition and functional redundancy in ephemeral resource uses using camera traps
Authors: Nakashima Yoshihiro , Hashizume Akane , Kanda Akane 
Published: July 2024

AbstractCamera traps have been widely used in wildlife research, offering significant potential for monitoring species interactions at ephemeral resources. However, raw data obtained from camera traps often face limitations due to observation censoring, where resource consumption by dominant animals may obscure potential resource use by less dominant animals. We extended time‐to‐detection occupancy modeling to quantify interspecific consumptive competition and redundancy of ecosystem functions through consumption between two species, while accounting for observation censoring. By treating resource use by rival species as censored data, we estimated the proportion of resources potentially used in the absence of rival species and calculated the loss caused by the rival species, which is defined as “Competition Intensity Index.” We also defined the Unique Functional Contribution, which represents the net functional loss when a species is removed, calculated by excluding the contribution potentially substituted by the other species. We also considered resource degradation and computed the quantity of resources acquired by each species. This established framework was applied to predation data on bird nests by alien squirrels and other predators (Case 1) as well as scavenging on mammalian carcasses by two carnivores (Case 2). In Case 1, the introduction of squirrels significantly affected the breeding success of birds. Although nests were being preyed upon by native crows also, our model estimated that Unique Functional Contribution by the squirrels was 0.47. This means that, by eradicating the squirrels, the reproductive success of the birds could potentially increase by as much as 47%. In Case 2, the Competition Intensity Index for foxes was 0.17, whereas that for raccoon dogs was 0.46, suggesting an asymmetric effect of resource competition between the two species. The frequency distribution of wet mass available to the two species differed significantly. This approach will enable a more robust construction of resource–consumer interaction networks.