bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to Promoting Eco‐Industrial Parks Development in China
Authors: Zhu Qinghua , Geng Yong , Sarkis Joseph , Lai Kee‐Hung 
Published: September 2014

SummaryFor at least the past two decades, eco‐industrial parks (EIPs) have been promoted as policy and commercial instruments for achieving industrial sustainable development. Yet, few EIPs have seen successful operational implementation, especially if they begin as standard industrial parks. Rapid economic growth, commensurate with increasing environmental damage in China, has resulted in officials’ further pursuing EIP policy as a significant element of the broader circular economy and ecological modernization efforts. This article examines the barriers for EIP development from industrial park senior manager perspectives. Using resource dependence theory and the resource‐based view as theoretical lenses, we investigate the external and internal barriers for EIP development in 51 Chinese industrial parks. A number of barriers are identified and grouped through a factor analysis. Cluster analysis is utilized to help categorize and evaluate the perceived levels of barriers and hardships experienced by various senior officials that manage the EIPs. It is found that few respondents encounter no significant barriers. Barriers related to technological development and capacity building are the most prevalent. These results highlight the relative importance of various activities that may be necessary by policy makers and other stakeholders to overcome the barriers. For example, cooperation in developing technological solutions for EIPs seems to be a major thrust that should be pursued by EIP development stakeholders. Other policy and managerial insights based on the general findings of this study are also presented.
Predicting well‐being longitudinally for mothers rearing offspring with intellectual and developmental disabilities
Authors: Grein K. A. , Glidden L. M. 
Published: September 2014

AbstractBackgroundWell‐being outcomes for parents of children with intellectual and developmental disabilities (IDD) may vary from positive to negative at different times and for different measures of well‐being. Predicting and explaining this variability has been a major focus of family research for reasons that have both theoretical and applied implications.MethodsThe current study used data from a 23‐year longitudinal investigation of adoptive and birth parents of children with IDD to determine which early child, mother and family characteristics would predict the variance in maternal outcomes 20 years after their original measurement. Using hierarchical regression analyses, we tested the predictive power of variables measured when children were 7 years old on outcomes of maternal well‐being when children were 26 years old. Outcome variables included maternal self‐report measures of depression and well‐being.ResultsFinal models of well‐being accounted for 20% to 34% of variance. For most outcomes, Family Accord and/or the personality variable of Neuroticism (emotional stability/instability) were significant predictors, but some variables demonstrated a different pattern.ConclusionsThese findings confirm that (1) characteristics of the child, mother and family during childhood can predict outcomes of maternal well‐being 20 years later; and (2) different predictor–outcome relationships can vary substantially, highlighting the importance of using multiple measures to gain a more comprehensive understanding of maternal well‐being. These results have implications for refining prognoses for parents and for tailoring service delivery to individual child, parent and family characteristics.
Oestradiol and Diet Modulate Energy Homeostasis and Hypothalamic Neurogenesis in the Adult Female Mouse
Authors: Bless E. P. , Reddy T. , Acharya K. D. , Beltz B. S. , Tetel M. J. 
Published: September 2014

Leptin and oestradiol have overlapping functions in energy homeostasis and fertility, and receptors for these hormones are localised in the same hypothalamic regions. Although, historically, it was assumed that mammalian adult neurogenesis was confined to the olfactory bulbs and the hippocampus, recent research has found new neurones in the male rodent hypothalamus. Furthermore, some of these new neurones are leptin‐sensitive and affected by diet. In the present study, we tested the hypothesis that diet and hormonal status modulate hypothalamic neurogenesis in the adult female mouse. Adult mice were ovariectomised and implanted with capsules containing oestradiol (E2) or oil. Within each group, mice were fed a high‐fat diet (HFD) or maintained on standard chow (STND). All animals were administered i.c.v. 5‐bromo‐2′‐deoxyuridine (BrdU) for 9 days and sacrificed 34 days later after an injection of leptin to induce phosphorylation of signal transducer of activation and transcription 3 (pSTAT3). Brain tissue was immunohistochemically labelled for BrdU (newly born cells), Hu (neuronal marker) and pSTAT3 (leptin sensitive). Although mice on a HFD became obese, oestradiol protected against obesity. There was a strong interaction between diet and hormone on new cells (BrdU+) in the arcuate, ventromedial hypothalamus and dorsomedial hypothalamus. HFD increased the number of new cells, whereas E2 inhibited this effect. Conversely, E2 increased the number of new cells in mice on a STND diet in all hypothalamic regions studied. Although the total number of new leptin‐sensitive neurones (BrdU‐Hu‐pSTAT3) found in the hypothalamus was low, HFD increased these new cells in the arcuate, whereas E2 attenuated this induction. These results suggest that adult neurogenesis in the hypothalamic neurogenic niche is modulated by diet and hormonal status and is related to energy homeostasis in female mice.
The use of light‐based (optical) detection systems as adjuncts in the detection of oral cancer and oral potentially malignant disorders: a systematic review
Authors: Rashid A , Warnakulasuriya S 
Published: September 2014

IntroductionIn recent decades, optical techniques utilising the principles of chemiluminescence and tissue autofluorescence have emerged to facilitate the early detection of any oral mucosal changes suspicious of cancer.PurposeTo evaluate the effectiveness of devices that utilise the principles of chemiluminescence and tissue autofluorescence as adjuncts in the detection of oral cancer and oral potentially malignant disorders (OPMDs).MethodsA systematic review of the published literature to evaluate the effectiveness of the ViziLite® and ViziLite® Plus with toluidine blue, MicroLux™/DL and the VELscope™ as aids in the detection of oral cancer and OPMDs.ResultsTwenty‐five primary studies published between 2004 and 2013 satisfied our criteria for selection – 13 utilised chemiluminescence and 12 tissue autofluorescence. Some had utilised both study methods on the same population. Chemiluminescence shows good sensitivity at detecting any OPMDs and oral cancer. However, it preferentially detects leukoplakia and may fail to spot red patches. The additive use of toluidine blue may improve specificity. Tissue autofluorescence is sensitive at detecting white, red and white and red patches, and the area of fluorescence visualisation loss (FVL) often extends beyond the clinically visible lesion. However, in addition to OPMDs, VELScope may detect erythematous lesions of benign inflammation resulting in false‐positive test results.ConclusionThere is limited evidence for their use in primary care, and these tools are better suited to specialist clinics in which there is a higher prevalence of disease and where experienced clinicians may better discriminate between benign and malignant lesions.
COMMUNICATION AS CARE AT END OF LIFE: AN EMERGING ISSUE FROM AN EXPLORATORY ACTION RESEARCH STUDY OF RENAL END‐OF‐LIFE CARE FOR ETHNIC MINORITIES IN THE UK
Authors: Wilkinson Emma , Randhawa Gurch , Brown Edwina A. , Da Silva Gane Maria , Stoves John , Warwick Graham , Akhtar Tahira , Magee Regina , Sharman Sue , Farrington Ken 
Published: September 2014

SUMMARYSouth Asian people have a higher risk of developing kidney disease, are disproportionately represented in the patient population requiring renal replacement therapy and wait longer to receive a kidney transplant, compared with white Europeans. As a result, there is a demand for end‐of‐life care, which meets the needs of this group of patients.Providing end‐of‐life care to patients from different cultures is a challenge for renal services as there can be barriers to communication in the form of language, delegated decision‐making within families and reluctance to discuss death.To explore end‐of‐life care for South Asians with kidney disease, 16 interviews with patients and 14 focus groups with care providers were conducted at four research sites in the UK with large South Asian populations. Using an action research design the data were analysed thematically and fed back to inform the research in a cyclical manner.If patients are not fully aware of their condition or of what end‐of‐life care is, it is less likely that they will be able to be involved in decision‐making about their care and this is compounded where there are communication barriers. Variations in care provider awareness and experience of providing end‐of‐life care to South Asian patients, in turn, contributes to lack of patient awareness of end‐of‐life care. Communication as care at the end of life should be explored further. Researching the South Asian patient experience of end of life highlights many relevant and generalisable issues.
SERVICING MULTI‐CULTURAL NEEDS AT THE END OF LIFE
Authors: Koffman Jonathan 
Published: September 2014

SUMMARYEthnic and cultural diversity are widespread across the world, but there is growing concern that end‐of‐life care is not offering Black Asian and Minority Ethnic (BAME) groups the most appropriate services. This article explores the experiences of BAME patients with advanced disease and the response of the healthcare professionals who care for them. Key questions include cultural influences on symptoms of advanced disease, communication and the role of religion and spirituality.
An in-vitro–in-vivo taste assessment of bitter drug: comparative electronic tongues study
Authors: Maniruzzaman Mohammed , Douroumis Dennis 
Published: September 2014

Abstract

Objectives
The efficiency of the Astree e-tongue and Taste Sensing system TS5000Z for the evaluation of the taste masking effect of hot melt extruded formulations was investigated in this study.

Methods
Hot melt extrusion (HME) processing was optimized using Randcastle single screw extruder (USA) to manufacture extrudates with desirable characteristics. Cationic model drug propranolol HCl (PRP) was processed with the anionic polymers – Eudragit L100 (L100) and Eudragit L100-55 (Acryl-EZE). Solid state of the drug in polymer matrices was evaluated by scanning electron microscopy (SEM), differential scanning calorimetry, particle size analysis, Fourier transform infrared (FTIR) and Nuclear magnetic resonance (NMR) analysis. In-vitro taste masking efficiency of the two polymers was performed by using two different e-tongues (Astree e-tongue and TS5000Z). The results obtained from both e-tongues were further compared and contrast to find out the sensor outputs in all formulations.

Key findings
Solid state analysis of the extruded formulations revealed the presence of amorphous PRP. Both e-tongues were able to detect the taste masking variations of the extrudates and were in good agreement with the in-vivo results obtained from a panel of six healthy human volunteers (R2 &gt; 0.84). However, each e-tongue sensor demonstrated different sensitivity, suggesting a careful consideration of the experimental findings during melt extrusion, is necessary for the development of taste-masked formulations. Furthermore, FTIR spectroscopy and NMR studies revealed possible drug polymer intermolecular interactions as the mechanism of successful taste masking.

Conclusions
HME can effectively be used to manufacture taste-masked extruded formulations, while both e-tongues demonstrated satisfactory taste analysis for the development of taste-masked formulations.
Diagnosis of gastrointestinal basidiobolomycosis: a mini‐review
Authors: El‐Shabrawi Mortada H. , Kamal Naglaa Mohamed , Kaerger Kerstin , Voigt Kerstin 
Published: September 2014

SummaryBasidiobolus ranarum (Entomophthoromycotina) very rarely affects the gastrointestinal (GI) tract. To date, reported paediatric GI basidiobolomycosis cases are 27 worldwide; 19 from Saudi Arabia and 8 from other parts of the world. Often these cases present a diagnostic dilemma, are prone to misdiagnosis and lack of disease confirmation by proper molecular methodologies. The fungal mass removed by surgery is usually sent for conciliar histopathology, isolation by fungal cultures and final molecular testing for basidiobolomycosis. The incidence of basidiobolomycoses, their predisposing factors and the molecular diagnosis of the fungus causing the disease in combination with a phylogenetic framework are reviewed.
Mucormycosis in India: unique features
Authors: Chakrabarti Arunaloke , Singh Rachna 
Published: September 2014

SummaryMucormycosis remains a devastating invasive fungal infection, with high mortality rates even after active management. The disease is being reported at an alarming frequency over the past decades from India. Indian mucormycosis has certain unique features. Rhino‐orbito‐cerebral presentation associated with uncontrolled diabetes is the predominant characteristic. Isolated renal mucormycosis has emerged as a new clinical entity. Apophysomyces elegans and Rhizopus homothallicus are emerging species in this region and uncommon agents such as Mucor irregularis and Thamnostylum lucknowense are also being reported. This review focuses on these distinct features of mucormycosis observed in India.
Mucormycosis in haematological patients: case report and results of prospective study in Saint Petersburg, Russia
Authors: Klimko Nikolay N. , Khostelidi Sofya N. , Volkova Alisya G. , Popova Marina O. , Bogomolova Tatyana S. , Zuborovskaya Ludmila S. , Kolbin Aleksey S. , Medvedeva Nadezhda V. , Zuzgin Ilya S. , Simkin Sergey M. , Vasilyeva Nataliya V. , Afanasiev Boris V. 
Published: September 2014

SummaryWe prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004–2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1–65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve‐week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.
Arabidopsis thaliana homeobox 12 (ATHB12), a homeodomain‐leucine zipper protein, regulates leaf growth by promoting cell expansion and endoreduplication
Authors: Hur Yoon‐Sun , Um Ji‐Hyun , Kim Sunghan , Kim Kyunga , Park Hee‐Jung , Lim Jong‐Seok , Kim Woo‐Young , Jun Sang Eun , Yoon Eun Kyung , Lim Jun , Ohme‐Takagi Masaru , Kim Donggiun , Park Jongbum , Kim Gyung‐Tae , Cheon Choong‐Ill 
Published: September 2014

Summary

Arabidopsis thaliana homeobox 12 (ATHB12), a homeodomain‐leucine zipper class I (HD‐Zip I) gene, is highly expressed in leaves and stems, and induced by abiotic stresses, but its role in development remains obscure.

To understand its function during plant development, we studied the effects of loss and gain of function. Expression of ATHB12 fused to the EAR‐motif repression domain (SRDX) – P35S::ATHB12SRDX (A12SRDX) and PATHB12::ATHB12SRDX – slowed both leaf and root growth, while the growth of ATHB12‐overexpressing seedlings (A12OX) was accelerated.

Microscopic examination revealed changes in the size and number of leaf cells. Ploidy was reduced in A12SRDX plants, accompanied by decreased cell expansion and increased cell numbers. By contrast, cell size was increased in A12OX plants, along with increased ploidy and elevated expression of cell cycle switch 52s (CCS52s), which are positive regulators of endoreduplication, indicating that ATHB12 promotes leaf cell expansion and endoreduplication. Overexpression of ATHB12 led to decreased phosphorylation of Arabidopsis thaliana ribosomal protein S6 (AtRPS6), a regulator of cell growth. In addition, induction of ATHB12 in the presence of cycloheximide increased the expression of several genes related to cell expansion, such as EXPANSIN A10 (EXPA10) and DWARF4 (DWF4).

Our findings strongly suggest that ATHB12 acts as a positive regulator of endoreduplication and cell growth during leaf development.
Specific Features of Early Stage of the Wound Healing Process Occurring Against the Background of Photodynamic Therapy Using Fotoditazin Photosensitizer–Amphiphilic Polymer Complexes
Authors: Rudenko Tatiana G. , Shekhter Anatoly B. , Guller Anna E. , Aksenova Nadezhda A. , Glagolev Nikolay N. , Ivanov Andrey V. , Aboyants Ruben K. , Kotova Svetlana L. , Solovieva Anna B. 
Published: September 2014

AbstractThere is a growing demand on the studies of the wound healing potentials of photodynamic therapy. Here we analyze the effects of Fotoditazin, an e6 chlorine derivative, and its complexes with amphiphilic polymers, on the early stage of wound healing in a rat model. A skin excision wound model with prevented contraction was developed in male albino rats divided into eight groups according to the treatment mode. All animals received injections of one of the studied compositions into their wound beds and underwent low‐intensity laser irradiation or stayed un‐irradiated. The clinical monitoring and histological examination of the wounds were performed. It has been found that all the Fotoditazin formulations have significant effects on the early stage of wound healing. The superposition of the inflammation and regeneration was the main difference between groups. The aqueous solution of Fotoditazin alone induced a significant capillary hemorrhage, while its combinations with amphiphilic polymers did not. The best clinical and morphological results were obtained for the Fotoditazin–Pluronic F127 composition. Compositions of Fotoditazin and amphiphilic polymers, especially Pluronic F127, probably, have a great potential for therapy of wounds. Their effects can be attributed to the increased regeneration and suppressed reactions changes at the early stages of repair.
Safety and tolerability of immune globulin intravenous (human), 10% solution in Japanese subjects with mild to moderate Alzheimer's disease
Authors: Arai Heii , Ichimiya Yosuke , Shibata Nobuto , Nakajima Takashi , Sudoh Shinji , Tokuda Takahiko , Sujaku Tetsujo , Yokokawa Shigeyoshi , Hoshii Naoki , Noguchi Hideaki , Bille Anne 
Published: September 2014

AbstractBackgroundImmune globulin intravenous (IGIV), 10% is a donor‐derived polyclonal human immunoglobulin G antibody mixture that has potent immune modulatory properties and contains conformation selective anti‐amyloid antibodies. We evaluated the safety and tolerability of multiple doses of IGIV, 10% in Japanese patients with mild to moderate Alzheimer's disease.MethodsAmong the 16 subjects, 12 subjects were assigned to the IGIV group and 4 subjects to the placebo group. Subjects received a total of six infusions of either IGIV at a dose of 0.2 or 0.4 g/kg, or placebo every 2 weeks.ResultsA total of 33 treatment‐emergent adverse events (TEAE) occurred in 14 subjects: 13 TEAE in five subjects in both the IGIV 0.2 and 0.4 g/kg groups, and 7 TEAE in four subjects in the placebo group. The most common TEAE in the IGIV subjects were nasopharyngitis, injection‐site swelling, and erythema. All 26 TEAE in the IGIV group were considered to be mild. Only one mild TEAE (rash) was considered to be possibly related to the study drug. There were no significant differences in incidence of TEAE between the treatment groups. Four serious TEAE were reported, and all of these were considered to be unrelated to the study treatment. Other assessments related to safety revealed neither clinically significant abnormal values nor findings in the study.ConclusionIGIV is generally safe and well tolerated with multiple intravenous infusions at doses of 0.2 g/kg and 0.4 g/kg in Japanese patients with mild to moderate Alzheimer's disease.
Assessment of intra‐operative cell salvage haemolysis in the obstetric and orthopaedic clinical setting, in comparison with allogeneic blood
Authors: Sullivan I. J. , Faulds J. N. 
Published: September 2014

SUMMARYObjectives/BackgroundHaemolysis is still a re‐occurring theme in intra‐operative cell salvage (ICS) with further haemolysis possibly caused by suction pressure, washing/centrifuging process and aspiration method. Previous investigations, along with manufacturer's reports, state that between 75 and 95% of free haemoglobin (Hb) is removed by the washing and centrifugation process; however, if these results are above the expected levels, excess free Hb may remain after washing.The aim of this article was to quantify haemolysis levels whilst employing different aspiration methods from skimmed (orthopaedics) and pooled (obstetrics) surgery types and comparing this to allogeneic blood.Methods/MaterialsSamples obtained from 50 allogeneic units and 50 ICS cases (25 obstetric and 25 orthopaedic) were tested for plasma free Hb levels.ResultsFree Hb testing as a marker of haemolysis was greatest in orthopaedic 17·2 g L−1 (range: 1·7–57·0 g L−1), obstetric 2·8 g L−1 (range: 1·0–13·5 g L−1) and allogeneic 0·95 g L−1 (range: 0·2–4·8 g L−1) cases.ConclusionICS involving skimming collection techniques (orthopaedics) had significantly more haemolysis than pooled collections (obstetrics) (P < 0·001). Further analysis of orthopaedic data highlighted a difference between the three machines used with the Haemonetics OrthoPat (Haemonetics Ltd., Watford, UK) significantly higher with a free Hb of 29·8 g L−1 compared with the other two machines 6·7 g L−1 (P < 0·001). On comparison of ICS blood to allogeneic blood, free Hb levels obtained from ICS were significantly higher (P < 0·001).
The Use of Refundable Tax Credits to Increase Low-Income Children’s After-School Physical Activity Level
Authors: Dunton Genevieve , Ebin Vicki J. , Efrat Merav W. , Efrat Rafael , Lane Christianne J. , Plunkett Scott 
Published: September 2014

Objective:The current study investigates the extent to which a refundable tax credit could be used to increase low-income children’s after-school physical activity levels.Methods:An experimental study was conducted evaluating the effectiveness of an intervention offering a simulated refundable tax credit to parents of elementary-school-age children (n = 130) for enrollment in after-school physical activity programs. A randomized controlled design was used, with data collected at baseline, immediately following the 4-month intervention (postintervention), and 6 weeks after the end of the intervention (follow-up). Evaluation measures included (1) enrollment rate, time spent, weekly participation frequency, duration of enrollment, and long-term enrollment patterns in after-school physical activity programs and (2) moderate to vigorous physical activity.Results:The simulated tax credits did not significantly influence low-income children’s rates of enrollment in after-school physical activity programs, frequency of participation, time spent in after-school physical activity programs, and overall moderate-to-vigorous intensity physical activity at postintervention or follow-up.Conclusion:The use of refundable tax credits as incentives to increase participation in after-school physical activity programs in low-income families may have limited effectiveness. Lawmakers might consider other methods of fiscal policy to promote physical activity such as direct payment to after-school physical activity program providers for enrolling and serving a low-income child in a qualified program, or improvements to programming and infrastructure.