bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of greywater using a non-aerated combined horizontal and vertical flow constructed wetland
Authors: Bryant Isaac Mbir , Akpah Daniel , Ogum Mary Aku , Gyamfi Emmanuella Ernestina , Baka Nancy 
Published: July 2024

ABSTRACT

Human, animal, and plant health is universally paramount, yet the release of poorly treated wastewater into the environment poses a significant risk to all life forms. Hence the need to employ wastewater treatment technologies to curb these health risks. Due to the need to adopt sustainable wastewater treatment technologies, this study investigated the use of a non-aerated hybrid horizontal and vertical flow constructed wetland for the removal of heavy metals and microorganisms from greywater. This was done at six different hydraulic retention times. Results showed significant reductions (p &lt; 0.05) in heavy metal (manganese, zinc, cadmium, magnesium, chromium, and iron) concentrations, with some showing compliance to Ghana's Environmental Protection Agency and the United Kingdom National Environment Regulation recommended discharge limits. Heavy metal concentrations in effluent samples ranged from as low as 0.00 ± 0.15–0.23 ± 0.06 mg/L. Furthermore, there were significant reductions in Escherichia coli and Salmonella typhi (p &lt; 0.05), which also showed compliance to Ghana's Environmental Protection Agency effluent discharge standards. The effluents from the system at HRT 3 days showed high removal efficiency ranges of 82–90% of bacteria. It is recommended that hybrid constructed wetlands should be incorporated in the treatment of greywater.
Matrine-loaded Nano-liposome Induces Apoptosis in Human Esophageal-squamous Carcinoma KYSE-150 Cells
Authors: Zhao Kai , Cai Yun , Raza Faisal , Zafar Hajra , Pan Liang , Zheng Xifeng , Xu Wenjie , Li Ran , Shi Feng , Ma Yongbin 
Published: July 2024

Introduction:
Esophageal-Squamous Cell Carcinoma (ESCC) is often diagnosed at the middle or
late stage, thus requiring more effective therapeutic strategies. Pharmacologically, the anti-tumor activity of
the principal active constituent of Sophora flavescens, matrine (MA), has been explored widely. Notwithstanding,
it is significant to nanotechnologically enhance the anti-tumor activity of MA in view of its potential to
distribute non-tumor cells.

Methods:
Herein, MA-loaded Nano-Liposomes (MNLs) were prepared to enhance the effect of anti-ESCC.
The MNL showed a smaller sized particle (25.95 ± 1.02 nm) with a low polydispersed index (PDI = 0.130 ±
0.054), uniform spherical morphology, good solution stability, and encapsulated efficiency (65.55% ± 2.47).
Furthermore, we determined the characteristics of KYSE-150 cells by cell viability assay, IC50, Mitochondrial
Membrane Potential (MMP), Western blot, and apoptotic analysis, which indicated that MNLs down-regulated
the cell viability and IC50 in a concentration-dependent manner and induced a significant change in JC-1 fluorescence
from red to green.

Results:
The above observations resulted in increased Bax and Caspase-3 levels, coupled with a substantial decrease
in Bcl-2 and apoptotic promotion at the advanced stage compared with MA.

Conclusion:
Based on these results, MNLs may serve as a more effective and promising therapeutic option for
ESCC.
Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, and Betti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands
Authors: Khan Danish , Kumari Beauty , Alzahrani Abdullah Yahya Abdullah , Dua Neha , Shaily  , Maurya Nirma 
Published: July 2024

:
This study outlines the development of a novel approach utilizing microwave
assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese
(II) and cobalt (II) in conjunction with chroman-4-one amino ligands. This research introduces
a unique catalytic system capable of synthesizing various heterocyclic compounds,
including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol dehydrogenation.
The synthesis involved the preparation and characterization of a series of chroman-
4-one amino ligands (C1-C6) using standard analytical techniques. These ligands, in
combination with MnCl2‧4H2O and CoCl2, demonstrated remarkable catalytic activity,
effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ
formation of metal complexes with the ligands during the reaction. Characterization using
ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II and Int-III)
throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of the catalytic
system, evidenced by the evolution of H2 gas.
Overexpression of NOP58 Facilitates Proliferation, Migration, Invasion, and Stemness of Non-small Cell Lung Cancer by Stabilizing hsa_circ_0001550
Authors: Jiang Yiqian , Cai Ying , Bao Yanhong , Kong Xiangyang , Jin Haigang 
Published: July 2024

Background:
NOP58 ribonucleoprotein (NOP58) is associated with the recurrence of lung adenocarcinoma.

Aims:
Few investigations concentrate on the role of NOP58 in non-small cell lung cancer (NSCLC), which is the
focus of our current study.

Methods:
Following transfection, the proliferation, migration, and invasion of NSCLC cells were assessed by 5-
ethynyl-2’-deoxyuridine (EdU), wound healing, and transwell assays. The percentage of CD9+ cells was evaluated
by flow cytometry assay. Based on target genes and binding sites predicted through bioinformatics analysis, a
dual-luciferase reporter assay was performed to verify the targeting relationship between hsa_circ_0001550 and
NOP58. The effect of NOP58 overexpression on hsa_circ_0001550 stability was gauged using Actinomycin D.
The hsa_circ_0001550 and NOP58 expression levels, as well as protein expressions of CD44, CD133, OCT4, and
SOX2 in NSCLC cells were determined by quantitative real-time PCR and Western blot, respectively.

Results:
Hsa_circ_0001550 was remarkably up-regulated in NSCLC cell lines A549 and PC9, silencing of which
weakened cell abilities to proliferate, migrate and invade, decreased CD9+ cell ratio, and diminished protein
expressions of CD44, CD133, OCT4, and SOX2. NOP58 could bind to hsa_circ_0001550 and stabilize its expression,
and NOP58 overexpression partially abrogated hsa_circ_0001550 knockdown-inhibited NSCLC cell
proliferation, migration, invasion and stemness.

Conclusion:
Overexpression of NOP58 facilitates proliferation, migration, invasion, and stemness of NSCLC
cells by stabilizing hsa_circ_0001550, hinting that NOP58 is a novel molecular target for NSCLC therapy.
Graves' Disease in Hypopituitarism Due to Pituitary Apoplexy
Authors: Mura Chiara , Sonnino Rebecca , Crispino Laura , Rota Carlo Antonio , Pontecorvi Alfredo 
Published: July 2024

Background:
Central hypothyroidism and autoimmune hyperthyroidism are contrasting
pathologies requiring careful hormone monitoring for restoring euthyroidism. Their coexistence
is rare and challenging for clinicians [1, 2].

Case Report::
We have, herein, presented the case of a 41-year-old female patient with an unremarkable
clinical history except for chronic autoimmune thyroiditis in euthyroidism. At the 21st
week of gestation, she experienced a spontaneous abortion. The patient underwent an assessment
of the uterine cavity, which was complicated by bleeding and hypotensive shock. In the
postoperative course, the patient presented worsening headache, and after an MRI, the diagnosis
of pituitary apoplexy due to an ischemic-hemorrhagic base was made. Laboratory tests showed
anterior panhypopituitarism. Multiaxial replacement therapy was initiated with hydrocortisone,
levothyroxine (LT4), and subsequently estrogen-progestin and GH. After two years of good
recovery with stable LT4 dosage, the patient experienced palpitations and fine tremors; blood
tests showed hyperthyroidism with suppressed Thyroid-stimulating Hormone (TSH) levels and
elevated free thyroid fractions and anti-TSH receptor antibodies. Diagnosis of Graves’ disease
was made, and therapy with methimazole was initiated. During antithyroid therapy, TSH remained
persistently suppressed, consistent with the underlying central hypothyroidism. This
condition required close follow-up, with monitoring based solely on free thyroid hormone levels.
After six months of antithyroid therapy, disease remission was achieved, with negative antibodies
and mild hypothyroxinemia. Therefore, methimazole was discontinued and replacement
therapy gradually resumed until optimal hormone levels were reached.

Conclusion:
This case is unique demonstrating autoimmune hyperthyroidism to coexist with
central hypothyroidism, rendering TSH a misleading disease progression indicator. Consequently,
managing Graves' disease has become more complex and challenging
Systematic Review and Meta-Analysis of Randomized Controlled Studies of the Fuke Qianjin Capsule....
Authors: Lu Si-Qi , Han Qian-Xi , Xv Long-Chen , Zhou Ping-Da , Zhou Jia-Meng , Wang Wei , Pan Jie , Zhu Wen-Tao 
Published: July 2024

Objective:
This research aims to evaluate the efficacy and safety of the Fuke Qianjin
capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease, including
the associated complications (endometritis and adnexitis).

Methodology:
We searched 4 Chinese and 3 English databases from their establishment to May,
2023. A randomized controlled trial (RCT) of the Fuke Qianjin capsule combined with antibiotics
was included in the trial group. The meta-analysis used the RevMan 5.4 software provided by
the Cochrane collaboration network.

Results:
A total of 103 RCTs were included, specifically 58 on chronic pelvic inflammatory disease,
6 on endometritis, and 39 on adnexitis (n= 9820, trial group n = 4925, control group n =
4895). The results of the meta-analysis demonstrated that the total effective rate of the Fuke Qianjin
capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease
(RR=1.21, 95%CI [1.18, 1.25], Z=14.86, p < 0.00001), endometritis (RR=1.22, 95%CI [1.13,
1.31], Z=5.31, p < 0.00001), and adnexitis (RR=1.26, 95%CI [1.23, 1.30], Z=16.49, p < 0.00001)
was significantly better than that of antibiotics alone. Equally important, the relief time of clinical
symptoms, the incidence of adverse reactions, and the recurrence rate (p < 0.05) were significantly
lower than those of antibiotics alone.

Conclusion:
The Fuke Qianjin capsule combined with antibiotics was found to be superior to
those in the antibiotic group alone. However, this conclusion necessitates further improvements,
such as being supported by a greater number of high-quality and substantive research samples.
Developments and antioxidant evaluation of Sesbania sesban-leaf-extract loaded carboxymethyl cellulose hydrogel as a potential skin cosmetic
Authors: Nguyen Thi Ngoc Phuong , Nguyen Doan Xuan Tien , Nguyen Ngoc Yen , Nguyen Quoc Chau Thanh , Pham Duy Toan 
Published: July 2024

Natural antioxidant products are receiving great attention as a safe alternative to chemically synthesized ones. For this, the phenolic compounds in the Sesbania sesban L. leaves possess potential antioxidant activities. Therefore, in this study, the Sesbania sesban L. leaf extract (SSE) was prepared and incorporated in the carboxymethyl cellulose (CMC) hydrogel as a natural antioxidant product. Firstly, the SSE was produced by the sonication-assisted extraction method, which demonstrated a total phenolic content of 61.44 ± 7.23 mg gallic acid equivalent/g dry powder weight, and a high antioxidant activity (IC50 = 15.381 ± 1.270 µg/mL). Then, the SSE was loaded into the CMC hydrogel and physicochemically evaluated in terms of physical observation, viscosity, gelation time, and drug release profiles. The hydrogel showed acceptable properties with a gradual release of polyphenol content over two stages for at least 180 min. Finally, utilizing the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test, the antioxidant action of the SSE was well-maintained in the SSE loaded CMC hydrogel. In summary, the SSE loaded CMC hydrogel could be further investigated to become a potential cosmetic in the market.
CLINICAL AND MICROBIOLOGICAL PROFILE OF PATIENTS ADMITTED WITH PNEUMONIA PRESENTING TO A TERTIARY CARE HOSPITAL IN SOUTHERN RAJASTHAN
Authors: AMIT SATISH GUPTA  , HARSH SHARMA  , VIDUSHI MEEL  
Published: July 2024

Objective: Pneumonia is a leading cause of morbidity and mortality in India. This study was conducted to understand the clinical and microbiological profile of pneumonia patients presenting to our hospital and also to understand the resistance pattern among them.
Methods: It was a retrospective observational study. Duration of the study was 6 months (June 2023 to December 2023). All patients admitted with a diagnosis of pneumonia (CAP, HAP, VAP) were included in the study and data was collected from previous medical records. Only those patients with pneumonia whose sputum or BAL (bronchoalveolar lavage) culture was positive for an organism were included in the study.
Results: A total of 50 patients with pneumonia were included the study. Majority of the patients were males (72 %) with average age of 62. Community acquired pneumonia was diagnosed in 21 patients, hospital acquired pneumonia in 15 patients and ventilator associated pneumonia in 14 patients. Most common organism isolated was Klebsiella pneumoniae (36 %), followed by Acinetobacter baumannii (24 %), pseudomonas aeruginosa (16 %), E.coli (10 %) and others (14 %). Organisms isolated from hospital and ventilator associated pneumonia showed higher prevalence of carbapenem resistance than those isolated from community acquired pneumonia patients.
Conclusion: Klebsiella pneumoniae was the most common organism isolated in CAP, HAP and VAP patients in our study. The resistance pattern of Klebsiella pneumoniae showed higher prevalence of carbapenem resistance in hospital and ventilator associated pneumonia patients as compared to CAP patients.
Keywords: Pneumonia, Hospital acquired pneumonia, Ventilator Associated pneumonia, Klebsiella pneumoniae
CORRIGENDUM
Authors: Team Editorial 
Published: July 2024

In the Journal Teme, XLVII, No 4, October - December, 2023, in the article:Jelena Grubor, Jasmin HalitovićTHE DEGREE OF NEGATIVITY OF MORPHOLOGICAL, SYNTACTIC AND LEXICAL NEGATION IN ENGLISH AS SEEN BY ENGLISH LANGUAGE AND LITERATURE STUDENTSТEME, XLVII, No. 4, October - Dеcember 2023, pp. 841-856https://doi.org/10.22190/TEME221004052Gin online pdf and printed version of article, in chapter References, reference:Halitović, J. (2021). Negative forms in the English language. Unpublished master’s thesis. State University of Novi Pazar, Serbia.was ommited (page 854) and according to that the last paragraf on page 847 was correted.The Editor-in-Chief has decided to publish a corrigendum for this article, as well as corrected pages 847 and 854. Link to the corrected article:http://teme2.junis.ni.ac.rs/index.php/TEME/article/view/1712https://doi.org/10.22190/TEME221004052G
Caribbean Bodies of Global Desire: Tourism and Eroticism in Contemporary Cinema
Authors: Planas Justo 
Published: July 2024

Tourism is a crucial economic sector in many Caribbean nations and the primary channel for direct interaction between the local population and visitors from around the world. Although not typically recognized in official statistics, Caribbean bodies effectively transform into a tourist attraction that supports the livelihoods of low-income families and makes a significant contribution to the domestic economy of the islands. Through an analysis of films set in the Dominican Republic, Haiti, and Cuba, this article debates the intricate connections between pleasure economies, traditional gender roles, and familial structures, while it challenges the prevailing victim-victimizer narrative and provides a multifaceted perspective on sex tourism. Access by first-world tourists to international mobility and foreign currency creates a power imbalance in their interactions with Caribbean individuals. This imbalance worsens existing disparities related to gender, race, and age. In this context, Holy Beasts (La fiera y la fiesta, 2019) is examined as a notable example, satirically deconstructing conventional narratives of erotic commodification in the Caribbean.
El turismo es un sector económico crítico en muchas naciones del Caribe y el principal canal de interacción directa entre la población local y los visitantes de todo el mundo. Aunque no suelen ser reconocidos en las estadísticas oficiales, los cuerpos caribeños se transforman efectivamente en una atracción turística que apoya el sustento de las familias de bajos ingresos y hace una contribución significativa a la economía nacional de las islas. A través de un análisis de películas ambientadas en la República Dominicana, Haití y Cuba, este artículo expone las intrincadas conexiones entre las economías del placer, los roles tradicionales de género y las estructuras familiares, a la vez que desafía la narrativa predominante de víctima-victimario y proporciona una perspectiva multifacética sobre el turismo sexual. El acceso de los turistas del primer mundo a la movilidad internacional y a las divisas internacionales crea un desequilibrio de poder en sus interacciones con los individuos del Caribe. Este desequilibrio empeora las disparidades existentes relacionadas con el género, la raza y la edad. En este contexto, La fiera y la fiesta (2019) se examina como un ejemplo notable que deconstruye satíricamente las narrativas convencionales de mercantilización erótica en el Caribe.
Analysis of Demudification Drying of Peanut Seeds (Arachis hypogaea L.) and Identification of Seed Quality
Authors: Sholikah Pipit Elok Nikmatus , Susilo Bambang , Sutan Sandra Malin , Damayanti Retno , Hermanto Mochamad Bagus 
Published: July 2024

One strategy to increase peanut production is to use good-quality seeds. The content of the seed determines the quality of the seed. Drying with low relative humidity can lower the drying temperature so that drying is done quickly and seed quality is maintained. This research was conducted to analyze the process and differences in peanut seed drying using dehumidifier drying and oven drying methods. Drying was carried out using a dehumidifier and oven drying machine at 30 °C, 40 °C, and 50 °C until the moisture content reached 9%, with observations every 30 minutes. Then the dried seeds were analyzed for their physical and physiological qualities. The results showed that the time needed for dehumidifier drying was faster than oven drying, with the details of dehumidifier machine drying at 30 °C, 40 °C, and 50 °C being 18.5 hours, 15 hours, and 10.5 hours. While drying in the oven at the same temperature, it takes 21 h, 17 h, and 12 h. From the results of the analysis of the physical quality of the seeds, the germination test, and the vigor test, it can be seen that dehumidifier drying gave the highest seed percentage results of 98%, 98%, and 88%. Keywords: Dehumidifier, Drying, Peanuts, Seed Quality, Water content.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS WEBSITE WORDWALL TERHADAP HASIL BELAJAR PENDIDIKAN PANCASILA SISWA KELAS IV SDN 101765 BANDAR SETIAPENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS WEBSITE WORDWALL TERHADAP HASIL BELAJAR PENDIDIKAN PANCASILA SISWA KELAS IV SDN 101765 BANDAR SETIA
Authors: Tumanggor Musdalifa 
Published: July 2024

Tujuan Penelitian ini untuk mengetahui (1) kelayakan media pembelejaran berbasis webiste wordwall yang dikembangkan pada mata pelajaran Pendidikan Pancasila siswa kelas IV SD Negeri 101765 Bandar Setia T.A 2023/2024. (2) efektivitas media pembelejaran berbasis website wordwall yang dikemangkan pada mata pelajaran Pendidikan Pancasila siswa kelas IV SD Negeri 101765 Bandar Setia T.A 2023/2024 dan (3) kepraktisan media pembelajaran berbasis website wordwall yang dikembangkan pada mata pelajaran Pendidikan Pancasila siswa kelas IV SD Negeri 101765 Bandar Setia T.A 2023/2024. Jenis penelitian ini mengunakan Research and Development (R&D), subjek dalam penelitian ini adalah peserta didik SD Negeri 101765 Bandar Setia kelas 4 A dengan total keseluruhan siswa berjumlah 20 siswa. Metode penelitian ini adalah pengembangan media yang mengacu pada model pengembangan ADDIE dengan 5 langkah prosedur pengembangan yaitu Analyze (analisis), Design (desain), Development (pengembangan), Implementation (implementasi), dan Evaluation (evaluasi). Hasil dari penelitian menunjukkan bahwa Uji kelayakan dari media pembelajaran mendapatkan persentase oleh ahli materi 93,75% dengan kategori “Sangat Layak” dan persentase oleh ahli media 87,5% dengan kategori “Sangat Layak”. Sehingga media pembelajaran berbasis website wordwall sangat layak untuk digunakan dalam kegiatan proses pembelajaran. Uji kepraktisan diperoleh dari penilaian oleh praktisi pendidikan dengan mendapatkan persentase 91,76% dengan kategori “Sangat Praktis”. Serta media pembelajaran berbasis website wordwall yang dikembangkan dan diterapkan telah mendapat respon yang baik oleh peserta didik. Ditunjukkan bahwa rata-rata bahwa nilai pre test siswa adalah 46,75% dan postest 87,50%. Sehingga untuk hasil efektifitas menjukkan hasil yang sangat signifikan, dimana persentase efektifitas pre test adalah 20% sedangkan untuk efektifitas post tes adalah 95% dengan kategori “Sangat Efektif”. Sehingga media pembelajaran berbasis website wordwall sangat efektif digunakan sebagai media pembelajaran.
Karakterisasi Sifat Fisis dan Mekanis Komposit Berbahan Sabut Lontar dalam Aplikasi Papan Partikel
Authors: Syamsuddin Sahara , Kusmiran Amirin , Fajar Fajar , Apriliah Risky 
Published: July 2024

This research used the natural fiber of the Palmyra fruits for composite particle manufacturing, and the physical and mechanical properties were studied on these composite particles. Raw material manufacturing uses the hand lay-up technique with a uniform volume fraction and random fiber in the composite. The presentations of the ratio composition of both fibers of palmyra fruits and epoxy resin are 75:25 for sample A, 70:30 for sample B, 65:35 for sample C, 60:40 for sample D, and 55:45 for sample E. This research shows that densities of the sample A to sample E are in range 0.47 g/cm3 to 0.60 g/cm3, and a sample A has the highest development thickness, with 72.61%, and the lowest is in sample C, with 33.11 %. Water content testing shows that samples A, B, C, and E have range 2.75 % to 7.52 %, and sample D is 17.30 %. For modulus of rapture (MOR), sample A has higher MOR than sample B, C, D, and E. Whereas sample D has lower MOR than the other samples. Sample C has the highest value for modulus of elasticity (MOE), 5526.47 kg/cm2. This sample's high modulus of elasticity correlates with the percentage of thickness development where the percentage of thickness development of sample C is lowest at 33.11%. The analysis results with AND or OR logic show that samples A, B, and D does not match SNI 03-2105-2006 standards while C and E samples match with SNI 03-2105-2006 standards. Thus, the three samples are not recommended for development. While C and E samples can be developed into particle board by reducing moisture content and improving elasticity properties.