bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical versus non-anatomical resection for hepatocellular carcinoma
Authors: Marubashi S , Gotoh K , Akita H , Takahashi H , Ito Y , Yano M , Ishikawa O , Sakon M 
Published: April 2015

Abstract

Background
The optimal surgical resection method in patients with HCC to minimize the risk of local recurrence has not yet been determined. The aim of this study was to compare the prognosis following anatomical versus non-anatomical hepatic resection for hepatocellular carcinoma (HCC).

Methods
Consecutive patients with HCC without macroscopic vascular invasion, treated by curative resection between 1981 and 2012 at Osaka Medical Centre, were included in this retrospective study. The outcomes of patients selected by propensity score matching were compared.

Results
Some 1102 patients were included, 577 in the anatomical and 525 in the non-anatomical resection group. By propensity score matching, 329 patients were selected into each group. Demographic, preoperative and tumour variables were similar between the propensity score-matched groups, including tumour size, tumour multiplicity, α-fetoprotein level and 15-min indocyanine green retention rate at 15 min. The incidence of microvascular invasion was higher in the matched anatomical resection group (P = 0·048). Stratified analysis of recurrence-free and overall survival rates revealed no statistically significant differences between the two propensity score-matched groups (P = 0·704 and P = 0·381 respectively). There was also no significant difference in the early recurrence rate within 2 years after resection between these groups (P = 0·726). Subset analysis of the early recurrence-free survival rate in patients with and without microvascular invasion revealed no significant differences between the groups (P = 0·312 and P = 0·479 respectively).

Conclusion
The resection method had no impact on the risk of HCC recurrence or survival.
Affordable and rapid HPTLC method for the simultaneous analysis of artemisinin and its metabolite artemisinic acid in Artemisia annua L.
Authors: Khan Shazia , Ali Athar , Ahmad Shahzad , Abdin Malik Zainul 
Published: April 2015

AbstractArtemisinin (AN) and artemisinic acid (AA), valuable phyto‐pharmaceutical molecules, are well known anti‐malarials, but their activities against diseases like cancer, schistosomiasis, HIV, hepatitis‐B and leishmaniasis are also being reported. For the simultaneous estimation of AN and AA in the callus and leaf extracts of A. annua L. plants, we embarked upon a simple, rapid, selective, reliable and fairly economical high performance thin layer chromatography (HPTLC) method. Experimental conditions such as band size, chamber saturation time, migration of solvent front and slit width were critically studied and the optimum conditions were selected. The separations were achieved using toluene–ethyl acetate, 9:1 (v/v) as mobile phase on pre‐coated silica gel plates, G 60F254. Good resolution was achieved with Rf values of 0.35 ± 0.02 and 0.26 ± 0.02 at 536 nm for AN and 626 nm for AA, respectively, in absorption–reflectance mode. The method displayed a linear relationship with r2 value 0.992 and 0.994 for AN and AA, respectively, in the concentration range of 300–1500 ng for AN and 200–1000 ng for AA. The method was validated for specificity by obtaining in‐situ UV overlay spectra and sensitivity by estimating limit of detection (30 ng for AN and 15 ng for AA) and limit of quantitation (80 ng for AN and 45 ng for AA) values. The accuracy was checked by the recovery studies conducted at three different levels with the known concentrations and the average percentage recovery was 101.99% for AN and 103.84% for AA. The precision was analyzed by interday and intraday precision and was 1.09 and 1.00% RSD for AN and 1.22 and 6.05% RSD for AA. The analysis of statistical data substantiates that this HPTLC method can be used for the simultaneous estimation of AN and AA in biological samples. Copyright © 2015 John Wiley & Sons, Ltd.
A total population‐based cohort study of female psychiatric inpatients who have served a prison sentence
Authors: Steingrimsson Steinn , Sigurdsson Martin I. , Gudmundsdottir Hafdis , Aspelund Thor , Magnusson Andres 
Published: April 2015

AbstractBackgroundStudies of the overlap between severe mental disorder and criminality tend to focus on prison populations rather than psychiatric populations.AimsOur aims were to establish the prevalence of previous imprisonment among female psychiatric inpatients and test relationships between diagnoses, mortality and imprisonment.MethodsA nationwide cohort of 18–65‐year‐old women who had been hospitalised for psychiatric disorder between January 1983 and March 2008 was identified from a hospital records database and linked to the database of the Prison and Probation Administration of Iceland as well as the National Register of causes of death at Statistics Iceland from January 1985.ResultsSix thousand and ninety‐four women had had at least one psychiatric hospitalisation, 102 of them had been imprisoned on 172 occasions between them, giving an imprisonment rate of 118 per 100,000 over the 24 year period of study. The crude imprisonment proportion was 1.7% during a 20‐year follow‐up period; it was at its peak (5%) among 18–30 year‐olds at index admission. Substance use and personality disorders were the most common diagnoses associated with imprisonment. Mortality rates were not statistically different between those imprisoned and not (hazard ratio = 1.3, 95% confidence interval 0.5–3.5).Conclusion and implications for practiceWomen admitted to a psychiatric hospital have higher rates of imprisonment than the general population. Because admission predated imprisonment in most cases, this may be seen as an opportunity for early intervention to reduce later criminality. Copyright © 2015 John Wiley & Sons, Ltd.
Relationships of diet‐related blood parameters and blood lead levels with psychopathology and aggression in forensic psychiatric inpatients
Authors: Zaalberg Ap , Wielders Jos , Bulten Erik , van der Staak Cees , Wouters Anouk , Nijman Henk 
Published: April 2015

AbstractBackgroundEarlier studies have suggested associations between diet‐related blood parameters and both aggression and psychopathological symptoms, but little is known about this in forensic psychiatric inpatients.AimThis article aims to explore the levels of diet‐related blood parameters and their relationship to aggressive behaviour and/or psychopathology among Dutch forensic psychiatric inpatients.MethodsMinerals, vitamins, lead and fatty acid levels were measured in blood samples from 51 inpatients, well enough to consent and participate in the study, from a possible total of 99. Levels of aggression and psychopathology were assessed using questionnaires, observation instruments and clinical data. Associations between blood parameters and behavioural measures were calculated.ResultsLow average levels of vitamin D3 and omega (ω)‐3 fatty acids were found, with nearly two‐thirds of the patients having below recommended levels of D3, while vitamin B6 levels were high. Magnesium, iron, zinc, copper and lead were overall within reference values, but copper/zinc ratios were high. Several significant associations between levels of fatty acid measures and both aggression and psychopathology were observed.ConclusionIn our sample of forensic psychiatric inpatients, fatty acids – but not mineral or vitamin levels – were associated with aggression and psychopathology. A potentially causal link between fatty acids and aggression could be tested in a randomised, placebo‐controlled trial of fish oil supplements. General health of such patients might be improved by better vitamin D status (increased sun exposure and/or supplement use) and better ω‐3 fatty acid status (oily fish or fish oil consumption), but discouraging unnecessary self‐prescription of B vitamins where necessary. Copyright © 2015 John Wiley & Sons, Ltd.
A bifactorial solution to the Psychopathy Checklist: Screening Version in a sample of civil psychiatric patients
Authors: Boduszek Daniel , Dhingra Katie , Hyland Philip , Debowska Agata 
Published: April 2015

AbstractBackgroundThere is considerable debate about the underlying factor structure of the Psychopathy Checklist: Screening Version (PCL: SV). An established view is that it reflects a unitary construct underpinned by two correlated factors. More recent research has, however, undermined this conceptualisation.AimsOur aim was to compare 10 competing models of the PCL: SV in a sample of civil psychiatric patients.MethodTen distinct factor models were specified and tested using conventional confirmatory factor analytic techniques, along with confirmatory bifactor modelling.ResultsA bifactor model, including two general factors (interpersonal–affective and antisocial–lifestyle), and four subordinate factors (interpersonal, affective, antisocial and lifestyle) provided the best fit to the data. The reliability of the conceptualisation was supported through the use of composite reliability, and the differential relationships exhibited between the general factors and measures of personality, impulsivity and mental health.ConclusionsOur findings provide further weight to taking the two general psychopathy factors into account when interpreting the PCL: SV for clinical purposes. Copyright © 2015 John Wiley & Sons, Ltd.
Clinical and procedural impact of aortic arch anatomic variants in carotid stenting procedures
Authors: Burzotta Francesco , Nerla Roberto , Pirozzolo Giancarlo , Aurigemma Cristina , Niccoli Giampaolo , Leone Antonio Maria , Saffioti Silvia , Crea Filippo , Trani Carlo 
Published: April 2015

ObjectivesTo evaluate the impact of aortic arch variants in patients undergoing carotid artery stenting (CAS).BackgroundCAS is increasingly carried out to treat the patients with internal carotid artery (ICA) stenosis. Aortic arch anatomy may influence its feasibility and affect clinical outcome.MethodsAortic arch digital subtraction angiography was systematically performed before CAS. Aortic arch elongation and bovine arch variants were recorded. Catheter manipulation time (CMT) was assessed for each patient. Adverse cardiovascular and cerebral events were assessed at 30 days.ResultsA total of 282 consecutive patients undergoing CAS under proximal balloon occlusion (57.8%) or distal filter (42.2%) neuroprotection were enrolled (age, 72 ± 7 years; 72.7% males). Type II and III elongation variants were detected in 23.4% and 10.6% of patients, respectively; in total, 20.5% of the patients had bovine configuration. CMT was significantly influenced by aortic elongation (56.1 ± 16.5 min in patients with type III aortic arch configuration compared to 38.2 ± 11.6 min in patients with type I or type II, P < 0.01) and (in left ICA) by bovine configuration (49.2 ± 11.4 min in bovine variants vs. 37.7 ± 11.5 min in patients with nonbovine anatomy, P < 0.001). CMT, but not aortic arch anatomy, resulted the only independent predictor of 30‐day adverse outcome (hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.03–1.10, P < 0.01).ConclusionsAdverse aortic arch anatomies are frequently encountered in CAS procedures and are associated to longer procedural times. A longer CMT increases the risk for adverse outcome. These data suggest that a careful procedure planning aimed at a reduction of CMT may be pivotal to improve the safety of CAS procedures. © 2015 Wiley Periodicals, Inc.
Hepatic portal venous gas
Authors: Soon Wai Cheong , Liu Kevin Yifei , Blunt Dominic 
Published: April 2015

Key Clinical MessageDifferentiating hepatic portal venous gas (HPVG) and pneumobilia on the CT scan can be accomplished by comparing the pattern of intrahepatic air spread. HPVG can be an indicator of significant intra‐abdominal pathology and bowel ischaemia is the most common causative etiology for HPVG.
A Platinum Highly Concave Cube with one Leg on each Vertex as an Advanced Nanocatalyst for Electrocatalytic Applications
Authors: Lai Jianping , Niu Wenxin , Qi Wenjing , Zhao Jianming , Li Suping , Gao Wenyue , Luque Rafael , Xu Guobao 
Published: April 2015

AbstractThe front cover artwork for Issue 07/2015 is provided by a collaboration of groups at State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, and Departamento de Química Orgánica, Universidad de Córdoba, Spain. The image shows the structure of a Pt highly concave cube with one leg on each vertex and its electrocatalytic applications in electrochemiluminescence and alcohol oxidation. See the Communication itself at http://dx.doi.org/10.1002/cctc.201403042.
Effect of Gravity on the Hydrodynamics in an Unbaffled Stirred Vessel
Authors: Yang Feng L. , Zhou Shen J. 
Published: April 2015

AbstractThe hydrodynamics in an unbaffled stirred vessel were simulated in order to highlight the effect of gravity on pressure and velocity distributions. Two fluids with different viscosity were studied for the laminar and turbulent flow regimes, respectively. The simulation results were compared with experimental data from the literature. Results indicate that for the higher‐viscosity fluid, gravity only affects static pressure and that the effects of gravity on velocity and dynamic pressure are negligible. For the lower‐viscosity fluid, however, gravity imposes a pronounced impact on static pressure, dynamic pressure, velocity, and turbulent kinetic energy. These findings indicate that careful consideration is necessary for the role that gravity plays in the study of free‐surface hydrodynamics in unbaffled stirred vessels.
Pincer‐Type Platinum(II) Complexes Containing N‐Heterocyclic Carbene (NHC) Ligand: Structures, Photophysical and Anion‐Binding Properties, and Anticancer Activities
Authors: Li Kai , Zou Taotao , Chen Yong , Guan Xiangguo , Che Chi‐Ming 
Published: April 2015

AbstractTwo classes of pincer‐type PtII complexes containing tridentate N‐donor ligands (1–8) or C‐deprotonated N^C^N ligands derived from 1,3‐di(2‐pyridyl)benzene (10–13) and auxiliary N‐heterocyclic carbene (NHC) ligand were synthesized. [Pt(trpy)(NHC)]2+ complexes 1–5 display green phosphorescence in CH2Cl2 (Φ: 1.1–5.3 %; τ: 0.3–1.0 μs) at room temperature. Moderate‐to‐intense emissions are observed for 1–7 in glassy solutions at 77 K and for 1–6 in the solid state. The [Pt(N^C^N)(NHC)]+ complexes 10–13 display strong green phosphorescence with quantum yields up to 65 % in CHCl3. The reactions of 1 with a wide variety of anions were examined in various solvents. The tridentate N‐donor ligand of 1 undergoes displacement reaction with CN− in protic solvents. Similar displacement of the N^C^N ligand by CN− has been observed for 10, leading to a luminescence “switch‐off” response. The water‐soluble 7 containing anthracenyl‐functionalized NHC ligand acts as a light “switch‐on” sensor for the detection of CN− ion with high selectivity. The in vitro cytotoxicity of the PtII complexes towards HeLa cells has been evaluated. Complex 12 showed high cytotoxicity with IC50 value of 0.46 μM, whereas 1–4 and 6–8 are less cytotoxic. The cellular localization of the strongly luminescent complex 12 traced by using emission microscopy revealed that it mainly localizes in the cytoplasmic structures rather than in the nucleus. This complex can induce mitochondria dysfunction and subsequent cell death.
Soft Template Strategy to Synthesize Iron Oxide–Titania Yolk–Shell Nanoparticles as High‐Performance Anode Materials for Lithium‐Ion Battery Applications
Authors: Lim Joohyun , Um Ji Hyun , Ahn Jihoon , Yu Seung‐Ho , Sung Yung‐Eun , Lee Jin‐Kyu 
Published: April 2015

AbstractYolk–shell‐structured nanoparticles with iron oxide core, void, and a titania shell configuration are prepared by a simple soft template method and used as the anode material for lithium ion batteries. The iron oxide–titania yolk–shell nanoparticles (IO@void@TNPs) exhibit a higher and more stable capacity than simply mixed nanoparticles of iron oxide and hollow titania because of the unique structure obtained by the perfect separation between iron oxide nanoparticles, in combination with the adequate internal void space provided by stable titania shells. Moreover, the structural effect of IO@void@TNPs clearly demonstrates that the capacity retention value after 50 cycles is approximately 4 times that for IONPs under harsh operating conditions, that is, when the temperature is increased to 80 °C.
Multiple‐Stimulus‐Responsive Supramolecular Gels and Regulation of Chiral Twists: The Effect of Spacer Length
Authors: Miao Wangen , Yang Dong , Liu Minghua 
Published: April 2015

AbstractA new class of homologous gelators, LG12‐(CH2)n‐BSA, composed of bipyridinyl groups, L‐glutamic moieties having double dodecyl chains, and linked alkyl spacers with different lengths were synthesized. It was found that these gelators could immobilize medium‐polarity solvents readily and the behaviors of these gels showed a dependence on the spacer length. Of all the gels, the LG12‐(CH2)11‐BSA gels exhibited self‐healing property and multiple‐stimulus responsibility, such as heating, shaking, and sonication. The investigation of CD spectra indicated that the supramolecular chirality, which was attributed to the chiral transfer from the chiral center to the assemblies, was also closely related to the length of methylene spacers. The longer the alkyl spacers, the weaker the transmitted supramolecular chirality. Only LG12‐(CH2)1‐BSA gelators, which had the shortest spacers, formed right‐handed nanoscale chiral twists owing to crowded hydrogen bonding interactions. Moreover, the high‐polarity solvent DMF was found to be able to regulate the chiral twist as well as its pitch length readily.
“(Diphosphine)Nickel”‐Catalyzed Negishi Cross‐Coupling: An Experimental and Theoretical Study
Authors: Nicolas Emmanuel , Ohleier Alexia , D'Accriscio Florian , Pécharman Anne‐Frédérique , Demange Matthieu , Ribagnac Philippe , Ballester Jorge , Gosmini Corinne , Mézailles Nicolas 
Published: April 2015

AbstractThe use of a strongly donating “(bis‐dialkylphosphine)Ni” fragment promotes the catalytic coupling of a large range of ArCl and ArZnCl derivatives under mild conditions. Stoichiometric mechanistic investigations and DFT calculations prove that a Ni0/NiII cycle is operative in this system.
Synthetic Active Site Model of the [NiFeSe] Hydrogenase
Authors: Wombwell Claire , Reisner Erwin 
Published: April 2015

AbstractA dinuclear synthetic model of the [NiFeSe] hydrogenase active site and a structural, spectroscopic and electrochemical analysis of this complex is reported. [NiFe(‘S2Se2’)(CO)3] (H2‘S2Se2’=1,2‐bis(2‐thiabutyl‐3,3‐dimethyl‐4‐selenol)benzene) has been synthesized by reacting the nickel selenolate complex [Ni(‘S2Se2’)] with [Fe(CO)3bda] (bda=benzylideneacetone). X‐ray crystal structure analysis confirms that [NiFe(‘S2Se2’)(CO)3] mimics the key structural features of the enzyme active site, including a doubly bridged heterobimetallic nickel and iron center with a selenolate terminally coordinated to the nickel center. Comparison of [NiFe(‘S2Se2’)(CO)3] with the previously reported thiolate analogue [NiFe(‘S4’)(CO)3] (H2‘S4’=H2xbsms=1,2‐bis(4‐mercapto‐3,3‐dimethyl‐2‐thiabutyl)benzene) showed that the selenolate groups in [NiFe(‘S2Se2’)(CO)3] give lower carbonyl stretching frequencies in the IR spectrum. Electrochemical studies of [NiFe(‘S2Se2’)(CO)3] and [NiFe(‘S4’)(CO)3] demonstrated that both complexes do not operate as homogenous H2 evolution catalysts, but are precursors to a solid deposit on an electrode surface for H2 evolution catalysis in organic and aqueous solution.
Rational Design and Application of a Redox‐Active, Photoresponsive, Discrete Metallogelator
Authors: Afrasiabi Rouzbeh , Kraatz Heinz‐Bernhard 
Published: April 2015

AbstractA photoresponsive discrete metallogelator was rationally designed by incorporating a photochromic azobenzene subunit in the structure of a redox‐active ferrocene–peptide conjugate. The target molecule was purposefully equipped with a dipeptide unit capable of self‐assembly in response to sonication. The designed molecule was shown to undergo supramolecular self‐assembly and achieve organogelation in response to ultrasound, light, heat, and redox signals. The sol–gel phase transition of the designed gelator was found to be sensitive to a plethora of input stimuli, allowing the application of the sol–gel transition behavior in basic logic gate operations. A gel‐based NOT logic gate operation was realized when the redox‐active property of the organogel was examined by using different oxidizing agents. The smart response of the gelator was further exploited in designing XOR operations under oxidizing or non‐oxidizing conditions.
Fine‐Tuning of Single‐Molecule Conductance by Tweaking Both Electronic Structure and Conformation of Side Substituents
Authors: Aragonès Albert C. , Darwish Nadim , Im JongOne , Lim Boram , Choi Jeongae , Koo Sangho , Díez‐Pérez Ismael 
Published: April 2015

AbstractHerein, we describe a method to fine‐tune the conductivity of single‐molecule wires by employing a combination of chemical composition and geometrical modifications of multiple phenyl side groups as conductance modulators embedded along the main axis of the electronic pathway. We have measured the single‐molecule conductivity of a novel series of phenyl‐substituted carotenoid wires whose conductivity can be tuned with high precision over an order of magnitude range by modulating both the electron‐donating character of the phenyl substituent and its dihedral angle. It is demonstrated that the electronic communication between the phenyl side groups and the molecular wire is maximized when the phenyl groups are twisted closer to the plane of the conjugated molecular wire. These findings can be refined to a general technique for precisely tuning the conductivity of molecular wires.
ChemInform Abstract: BaMn9[VO4]6(OH)2: A Unique Canted Antiferromagnet with a Chiral “Paddle‐Wheel” Structural Feature.
Authors: Sun Kewen , Litvinchuk Alexander P. , Tapp Joshua , Lorenz Bernd , Moeller Angela 
Published: April 2015

AbstractDark‐red crystals of the title compound are hydrothermally synthesized from aqueous mixtures of MnCl2, NH4VO3, Ba(OAc)2, and LiCl (autoclave, 220 °C, 3—4 d, 55% yield).
ChemInform Abstract: Hydrothermal Synthesis and Characterization of a Two‐Dimensional Piperazinium Cobalt—Zinc Phosphate via a Metastable One‐Dimensional Phase.
Authors: Torre‐Fernandez Laura , Khainakova Olena A. , Espina Aranzazu , Amghouz Zakariae , Khainakov Sergei A. , Alfonso Belen F. , Blanco Jesus A. , Garcia Jose R. , Garcia‐Granda Santiago 
Published: April 2015

AbstractThe layered piperazinium cobalt‐zinc phosphate, (pipH2)1.5 (Co0.6Zn0.4)2(HPO4)2 (PO4)·H2O, is prepared under hydrothermal conditions from a mixture of CoCl2, ZnCl2, H3PO4 (85 wt%), and piperazine (pip) hexahydrate (autoclave, 180 °C, 6 d).
ChemInform Abstract: Graphite Oxide: A Simple and Efficient Solid Acid Catalyst for the Ring‐Opening of Epoxides by Alcohols.
Authors: Mirza‐Aghayan Maryam , Alizadeh Mahdi , Molaee Tavana Mahdieh , Boukherroub Rabah 
Published: April 2015

AbstractDepending on the predominating steric or electronic effects, the ring‐opening occurs regioselectively at the higher or lower substituted carbon of the epoxide.
ChemInform Abstract: Mild Silver‐Mediated Geminal Difluorination of Styrenes Using an Air‐ and Moisture‐Stable Fluoroiodane Reagent.
Authors: Ilchenko Nadia O. , Tasch Boris O. A. , Szabo Kalman J. 
Published: April 2015

AbstractThe reaction of α‐methyl styrene (III) also leads to the β‐difluorinated product but the methyl group migrates to the β‐position.
ChemInform Abstract: Silver‐Mediated Oxidative Vinylic C—H Bond Sulfenylation of Enamides with Disulfides.
Authors: Yang Luo , Wen Qing , Xiao Fuhong , Deng Guo‐Jun 
Published: April 2015

AbstractA plausible non‐chain radical mechanism based on mechanistic studies is suggested for the title transformation.