bluuebunny/crossref_metadata_2025_split huggingface dataset:
Greenhouse gas emissions during decomposition of cover crops and poultry litter with simulated tillage in 90‐day soil incubations
Authors: Salehin Sk Musfiq Us , Rajan Nithya , Mowrer Jake , Casey Kenneth D. , Somenahally Anil C. , Bagavathiannan Muthu 
Published: July 2024

AbstractInvestigating the impact of cover crops and manure on soil greenhouse gas (GHG) emissions is crucial for advancing our understanding of the climate‐smart potential of organic management practices. This soil incubation experiment was conducted to investigate the combined effects of manure and cover crop residue decomposition on soil carbon dioxide (CO2), nitrous oxide (N2O), and methane (CH4) emissions under simulated tillage conditions. Undisturbed soil cores, collected from an organic cotton (Gossypium hirsutum L.) field experiment, were incubated for 90 days in a 2 × 4 factorial design for 2 consecutive years. Four combinations of cover crop and poultry litter (PL) residues were the primary treatment factor. The amount of residues added in the incubation study reflected the cover crop biomass produced under field conditions and the amount of PL applied in the field. Residue treatments included PL only at the full application rate (250 kg ha−1), PL with oat (Avena sativa L.), PL with turnip (Brassica rapa subsp. rapa), and half the rate of PL with Austrian winter pea (Pisum sativum) (AWP). The residues were either soil incorporated or surface applied to simulate disking and no‐till field conditions. On average, 3.5% of applied carbon escaped as CO2 during the 90‐day incubation period across treatments. Similarly, on average, 0.75% of applied nitrogen escaped as N2O. The proportion of nitrogen emitted as N2O under simulated no‐till was 81.2% higher in 2020 (P < 0.05) compared to conventional tillage. In 2021, N2O emission was 35.8% higher (P < 0.1). When normalized over the amount of carbon added, total CO2 equivalent GHG emissions were the highest in the legume AWP treatment for both years. However, neither residue types nor simulated tillage affected net soil CH4 uptake (P > 0.1). While no‐till practices may increase soil total carbon and nitrogen stocks during the cover crops and manure decomposition, the impact on GHG emissions depends on residue type and should be considered in estimating the climate‐smart potential of organic management practices.
Sustainable development of local livelihoods in Vietnam: A demand‐driven approach through “One Commune, One Product”
Authors: Trang Nguyen Thuy , W. Kopp Steven , Tu Vo Hong 
Published: July 2024

Abstract“One Commune One Product” (OCOP) is a national target program intended to develop the rural economy of Vietnam. The goal of the OCOP program is to identify and promote competitive, marketable products that originate from local and indigenous resources. Since its nationwide implementation in 2018, nearly 5000 OCOP products have been evaluated and certified for OCOP status. The present study interviewed 600 Vietnamese consumers and employed the latent class choice model to investigate the consumers' willingness to pay for OCOP attributes, including the ethical attributes of traceability information, local production, and fair trade, along with the government “star rating” for the product and the OCOP certification label. Through a choice experiment, we identified two distinct consumer segments, one of which (about 74% of the sample) expressed preference and willingness to pay price premiums for the product attributes and the other which (about 26%) was unwilling to pay for any of the attributes. We also found that the consumers in the “Optimist” segment were willing to pay a price premium for “private” product attributes compared to “public” attributes. Consumers in the “Opponent” segment were characterized as highly price sensitive; they expressed lower levels of concern for the environment and lower preferences for local products. Based on these results, we propose some policy implications for continued development of the OCOP program and local livelihoods.
Plant‐derived bioactive peptides: A comprehensive review
Authors: Kadam Deepak , Kadam Aayushi , Koksel Filiz , Aluko Rotimi E. 
Published: July 2024

AbstractBioactive peptides that are derived through the enzymatic hydrolysis of proteins have garnered significant attention for their diverse health‐promoting properties. This article delves into the technology behind plant‐derived bioactive peptide production by emphasizing the principles of enzyme hydrolysis. Furthermore, the review highlights the refinement techniques, employing membrane ultrafiltration and various forms of column chromatography to isolate and purify these peptides effectively. The bioactive properties of protein hydrolysates encompass a range of health benefits, including antihypertensive, antioxidant, anti‐diabetic, anti‐obesity, and neuroprotective effects. Additionally, bioactive peptides demonstrate promise in inhibiting cancer cell growth, supporting bone health, and modulating immune responses. These properties hold immense potential for revolutionizing approaches to various health conditions. Continued research in this field promises further insights and breakthroughs, propelling bioactive peptides to the forefront of nutrition and healthcare innovation. The convergence of advanced technology and the multifaceted bioactivity of peptides present an exciting avenue for improving human well‐being and addressing a wide array of health challenges.
Fabricating Ion Sieves by 3D Printing for Selective Lithium Adsorption from Brines
Authors: Martínez Omar Jair Licea , Delgado Beatriz Guadalupe Saucedo , Rodríguez Luis Mario González , Sequeda Jair Fernando Rangel , Rivera Gloria Lourdes Dimas , Martínez Ricardo Briones , De Haro Del Río David Alejandro 
Published: July 2024

AbstractThis work presents the formation of a stable 3D monolith based on manganese oxide for the adsorption of lithium from brine. The precursor phase was prepared by microwave‐assisted hydrothermal synthesis and a subsequent calcination process to achieve the desired crystalline phase LiMn2O4. The monolith was formed using additive manufacturing, which allowed its size and shape to be controlled. Subsequently, this monolith was washed with a HCl solution to generate adsorption sites for lithium. The prepared materials were characterized by XRD, FTIR, TGA, N2 physisorption, and SEM‐EDS. Analysis confirmed that the 3D monolith retained its crystalline structure throughout the process. The kinetic characteristics of the adsorption process were evaluated using pseudo‐first and pseudo‐second order equations, as well as Freundlich and Langmuir equations, to describe thermodynamic equilibrium. Monoliths were able to capture lithium up to 13.84 mg/g and the Freundlich equation described the equilibrium (R2=0.9751), while the second‐order equation better described the kinetic behavior (R2=0.9130). Results showed that monoliths are selective towards lithium in the presence of competing cations. The stability of the materials was evaluated in adsorption‐desorption cycles, demonstrating a competitive reuse after five cycles. This research presents a promising new approach for developing efficient lithium extraction methods from brine.
Arsenate Stabilization via Dynamic Covalent Chemistry
Authors: Gaspar‐López Federico Javier , Lechuga‐Islas Víctor Daniel , Tlahuext Hugo , Navarrete‐Vazquez Gabriel , Moo‐Puc Rosa E. , Chale‐Dzul Juan B. , Tapia‐Benavides Antonio R. , Tlahuextl Margarita 
Published: July 2024

AbstractWe report the synthesis of arsenic heterocycles derived from saccharides 2–4 and AsCl3. Compounds 5 and 6 are stable in aqueous solutions, DMSO, or methanolic solutions. However, NMR and HPLC studies revealed that intramolecular trans‐esterification processes leads to dynamic equilibria. Theoretical studies revealed that three arsenates and two arsoranes participate in these intramolecular equilibria and account for the experimental spectroscopy and HPLC results. Through the correlation between the experimental and theoretical 13C NMR spectra, we proposed the speciation of arsenic Compounds 5 and 6. Moreover, experimental and theoretical IR spectra demonstrated that arsenates 5 A and 6 A predominate in the solid state. QTAIM studies were performed to explain the chemical shifts in the 13C NMR spectra. Biological studies suggest that the structural flexibility of Compounds 5 and 6 increase the cytotoxic and antiproliferative activities of these compounds.
Design, Synthesis and Evaluation of Thioacetamide‐Tethered Thiadiazole‐1,2,4‐Triazole Hybrids as SHP2 Inhibitors for Cancer Therapy
Authors: Mitra Rangan , Kumar Sandeep , Chaudhuri Aiswarya , Agrawal Ashish Kumar , Ayyannan Senthil Raja 
Published: July 2024

AbstractSrc homology‐2 (SH2) domain‐containing phosphatase‐2 (SHP2), the first protooncogenic phosphatase is a key mediator in the development and progression of various cancers. Several allosteric sites have been identified in SHP2, inhibitors of which are being developed. In the current study, we have designed and synthesized a library of 21 thioacetamide‐tethered thiadiazole‐1,2,4‐triazole hybrids (compounds 16–36) and evaluated their in vitro SHP2 inhibitory potential. Compound 28 (N‐(5‐(benzo[d][1,3]dioxol‐5‐yl)‐1,3,4‐thiadiazol‐2‐yl)‐2‐((5‐(4‐methoxyphenyl)‐4H‐1,2,4‐triazol‐3‐yl)thio)acetamide) emerged as the most potent SHP2 inhibitor (IC50=0.318±0.001 μM) inhibiting the enzyme in a mixed to non‐competitive manner. In silico studies revealed that the lead inhibitor strongly binds to the tunnel allosteric site of SHP2. Further, cytotoxicity studies revealed that compound 28 caused death of SHP2‐driven MCF‐7 (GI50=37.02±0.25 μM) and U87MG cells (GI50=68.69±0.21 μM) in a dose‐dependent manner and inhibited MCF‐7 cell colony formation and migration. Flow cytometric analysis showed that it exerted its antiproliferative effect on U87MG cells by inducing early apoptosis (Q2 phase) and inhibiting cell cycle progression at the G1 and S phase. Compound 28 was shown to increase oxidative stress in the U87 cells by promoting ROS generation and loss of mitochondrial integrity. In summary, the present study produced a potent SHP2 inhibitor (compound 28) with a promising in vitro cytotoxicity profile, thus meriting further investigation.
Facile Condensation of 2‐Aminobenzaldehydes into Azolo[4,5‐b]Quinolones
Authors: Opryshko Victoria E. , Zaitseva Elvira R. , Ivanov Dmitrii S. , Eshtukov‐Shcheglov Artur V. , Tyurin Anton P. , Mikhaylov Andrey A. , Smirnov Alexander Yu. , Baranov Mikhail S. 
Published: July 2024

AbstractAn operationally simple approach to azolo[4,5‐b]quinolines based on the condensation of 2‐aminobenzaldehydes with various azolones is developed. A series of 22 compounds was synthesized typically in good yields (40–92 %).
Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
Authors: Chandran Namitha , Bose Kuntal , Thekkantavida Amrutha Chandran , Thomas Riya Rachel , Anirudhan Karthika , Bindra Sandeep , Sura Sooraj , Hasan Haydara Ammar , Kumar Sunil , Rangarajan T. M. , Al‐Sehemi Abdullah G. , Gahtori Prashant , Kim Hoon , Mathew Bijo 
Published: July 2024

AbstractOximes, belonging to imines with the general formula of RR'C=NOH, are produced by the nucleophilic addition reaction between hydroxylamine with ketones or aldehydes, yielding corresponding aldoxime and ketoxime. The presence of hydrogen bond acceptor and donor is the classical feature of oxime‐containing structural framework. This review presents a summary of the role of oximes and its structure activity relationships including antimicrobial, anticancer, anti‐inflammatory, antihyperglycemic, insecticidal agents, along with their involvement in the treatment of organophosphorus poisoning. The review also focused on the pharmacological profile of lead molecules of several classes of oxime‐containing compounds.
R‐BINOL‐Chiral Phosphoric Acid Catalyzed Regioselective Synthesis of 7‐Oxo‐Pyrazolo[1,2‐a]Pyrazoles via [3+2] Cycloaddition Reaction of Morita Baylis Hillman Adducts with N, N’‐Cyclic Azomethine Imines
Authors: Karthikeyan S. , Choppella Sairathna , Murali Anna Chandrasekar , Subimol K. R. , Monica J. Helen Ratna , Ravva Mahesh Kumar , Kumar Ayyanoth Karthik Krishna 
Published: July 2024

AbstractWe report an efficient [3+2] cycloaddition protocol for the synthesis of pyrazolo[1,2‐a]pyrazolones from Morita‐Baylis‐Hillman adducts and N,N’‐cyclic azomethine imines. The R‐BINOL chiral phosphoric acid was identified as the suitable catalyst for the reported cycloaddition protocol. Almost all MBH adducts regioselectively delivered 7‐oxo‐pyrazolo[1,2‐a]pyrazoles at an efficient yield of 69–91 %. With exception, the MBH adducts derived from acrylonitrile deliver 5‐oxo‐pyrazolo[1,2‐a]pyrazoles comparatively at a higher yield than the 7‐oxo‐pyrazolo[1,2‐a]pyrazoles. The density functional theory (DFT) studies demonstrate that the reaction is thermodynamically more feasible in the presence of R‐BINOL chiral phosphoric acid.
Novel Coumarin‐Pyrazole‐Thiazoles Hybrids: Synthesis, Anticancer Activity, Molecular Docking and In Silico ADMET prediction Studies
Authors: Alsolimani Ayat K. , Ali Tarik E. , Assiri Mohammed A. , Shati Ali A. , Alfaifi Mohammad Y. , Elbehairi Serag E. I. 
Published: July 2024

AbstractA novel series of coumarin‐pyrazole‐thiazoles hybrids was designed. The methodology depended on a simple condensation reaction of 3‐(2‐oxo‐2H‐chromen‐3‐yl)‐1‐phenyl‐1H‐pyrazole‐4‐carboxaldehyde with a variety of thiazole compounds having amino or active methylene groups. In addition, another series of 1‐(thiazol‐2‐yl)‐3‐(2‐oxo‐2H‐chromen‐3‐yl)‐1H‐pyrazole‐4‐carboxaldehydes was also achieved by applying Vilsmeier‐Haack formylation on 3‐[1‐(2‐(thiazol‐2‐yl)hydrazineylidene]ethyl)‐2H‐chromen‐2‐ones. The obtained products were verified by spectral techniques such as IR, NMR, and mass spectra. To screen their abilities to inhibit cancer cell growth, these compounds were investigated against three tumor cell lines (MCF‐7, HepG2, and HCT116) using a standard method called SRB. The products 3 e, 7 b, 12 c and 14 a have considerable cytotoxic effects comparable to Doxorubicin. These products caused significant cell death by late apoptosis in all tumor cell lines. Furthermore, they preferentially induced G2 cell cycle arrest in MCF‐7 and HepG2 cells, while causing G1 cell cycle arrest in HCT116 cells. The molecular docking of these bioactive products showed good binding affinities with Cyclin‐dependent kinase 8 (CDK‐8). The ADMET‐predicted drug‐likeness properties of these bioactive compounds enable them to can used as promising anticancer agents.
Size‐Dependent Optical Properties and Exciton Self‐Trapping Emission in Carbon Quantum Dots
Authors: Van Duong Pham , Anh Thi Le , Duc Toan Le , Hong Minh Pham , Thanh Binh Nguyen , Hoang Tung Do , Dinh Lam Nguyen , Minh Hoa Nguyen 
Published: July 2024

AbstractCarbon quantum dots (CQDs), synthesized through controlled microplasma treatment of orange juice, exhibit unique luminescent characteristics. The impact of synthesis time on particle size was investigated. Deconvoluted emission spectra displayed broad bands, peaking at an excitation wavelength of 350 nm for CQD sizes of 2.06, 2.4, and 3.09 nm, indicating multiple fluorescence peaks. This suggests a mixture of CQDs with different excitation energies on their surfaces. Luminescence kinetics unveiled three exponential decay components with time constants of 2.73, 4.61, and 3.27 ns, indicating multiple luminescent centers. Emission behavior affected by excitation wavelengths ranging from 350 to 490 nm suggests that quantum transition probabilities are influenced by impurities or defects. These findings emphasize the size‐dependent optical properties and exciton self‐trapping (EST) emission of CQDs. The calculation of the Huang‐Rhys factor S values underscores the profound influence of carrier‐phonon coupling and the Huang‐Rhys factor on the emergence of ESTs within CQDs. Understanding these interactions is crucial for fully utilizing the capabilities of CQDs in applications spanning optoelectronics, sensors, bioimaging, and various technological fields.
ICP–MS Assisted EDX Tomography: A Robust Method for Studying Electrolyte Penetration Phenomena in Gas Diffusion Electrodes Applied to CO2 Electrolysis
Authors: Rieder Alain , Lorenzetti Julia , Zelocualtecatl Montiel Iván , Dutta Abhijit , Iarchuk Anna , Mirolo Marta , Drnec Jakub , Lorenzutti Francesca , Haussener Sophia , Kovács Noémi , Vesztergom Soma , Broekmann Peter 
Published: July 2024

AbstractA carbon paper‐based gas diffusion electrode (GDE) is used with a bismuth(III) subcarbonate active catalyst phase for the electrochemical reduction of CO2 in a gas/electrolyte flow‐by configuration electrolyser at high current density. It is demonstrated that in this configuration, the gas and catholyte phases recombine to form K2CO3/KHCO3 precipitates to an extent that after electrolyses, vast amount of K+ ions is found by EDX mapping in the entire GDE structure. The fact that the entirety of the GDE gets wetted during electrolysis should, however, not be interpreted as a sign of flooding of the catalyst layer, since electrolyte perspiring through the GDE can largely be removed with the outflow gas, and the efficiency of electrolysis (toward the selective production of formate) can thus be maintained high for several hours. For a full spatial scale quantitative monitoring of electrolyte penetration into the GDE, (relying on K+ ions as tracer) the method of inductively coupled plasma–mass spectrometry (ICP–MS) assisted energy dispersive X‐ray (EDX) tomography is introduced. This new, cheap and robust tomography of non‐uniform aspect ratio has a large planar span that comprises the entire GDE surface area and a submicrometer depth resolution, hence it can provide quantitative information about the amount and distribution of K+ remnants inside the GDE structure, in three dimensions.
Direct Quantitation of Poloxamer 188 in Adeno‐Associated Virus Products Using Reversed‐Phase Chromatography With Charged Aerosol Detection
Authors: Nguyen Tai , Sosic Zoran , Xu Chong‐Feng 
Published: July 2024

ABSTRACTPoloxamer 188 is a commonly used excipient in formulations to protect products against mechanical stress and adsorption loss. In this work, an analytical method was developed to directly and accurately quantitate the amount of Poloxamer 188 in the drug substance of three different adeno‐associated virus (AAV) serotypes. The method is based on reversed‐phase liquid chromatography separation of virus particles from Poloxamer 188 using a charged aerosol detector and provides linearity from 5 to 200 ppm. A good assay precision and analyte recovery allows its adaptability to potentially various applications from process development support to AAV drug product release testing.
Promoting teachers' advocacy and agency for equity in STEM education through research and reflection
Authors: Holincheck Nancy M. , Galanti Terrie M. , Butler Tiffany N. 
Published: July 2024

AbstractSystemic equity challenges in K‐12 STEM education place students from minoritized groups on an uneven footing, restricting access and opportunity for the diverse students who make up the majority population in US public schools. Teachers play a key role in advocating for equity and justice in STEM education. In positioning themselves as agents of change, they have the power to impact their classrooms, schools, and communities. Using a collaborative coding process informed by dominant and critical framings of equity in STEM education, we analyzed equity research presentations and final written reflections from a graduate course for practicing teachers (n = 23) focused on STEM integration. Teacher participants demonstrated one of four advocacy orientations: (a) equity in classroom teaching, (b) STEM education, (c) equity in STEM education, or (d) neither equity nor STEM. Our analysis of teachers' final course reflections led us to develop a rubric using principles of grammar to evaluate the levels of agency evident in teachers' statements. Most teachers were at least minimally agentic for STEM, but fewer teachers were agentic for equity. Only four of 23 teachers were highly agentic for equity in STEM education. We identify a need for more purposeful scaffolding in professional learning to build teacher advocacy and agency for equity in STEM education. Future research should explore the high‐leverage practices in STEM teacher education that foster advocacy and agency.
Shear strength equation of soils in a wide suction range under various initial void ratios
Authors: Song Zhaoyang , Zhang Zhihong 
Published: July 2024

AbstractShear strength equation is a basic theory for solving many geotechnical engineering problems. Although the shear strength equation has received widespread attention, shear strength of clay under wide suction range and different initial void ratio conditions cannot be well predicted. This study aims to establish a new strength equation applicable to soils within a wide suction range. Considering the capillary and adsorptive parts of soil–water interactions, a cohesion expression related to the degree of adsorbed water saturation Sra and the effective stress related to the degree of capillary water saturation Src are proposed. After that, based on the Mohr–Coulomb theory, a shear strength equation of unsaturated soils in a wide range of suction under various is proposed. Five parameters are included in the equation. It is easy to calibrate them through shear tests on saturated and the fully dried soils. It is verified that not only the sandy clay till and clayed silt but also the expansive soil's shear strength in wide ranges of suction under various can be well predicted.
Onset of a conceptual outline map to get a hold on the jungle of cluster analysis
Authors: Van Mechelen Iven , Hennig Christian , Kiers Henk A. L. 
Published: July 2024

AbstractThe domain of cluster analysis is a meeting point for a very rich multidisciplinary encounter, with cluster‐analytic methods being studied and developed in discrete mathematics, numerical analysis, statistics, data analysis, data science, and computer science (including machine learning, data mining, and knowledge discovery), to name but a few. The other side of the coin, however, is that the domain suffers from a major accessibility problem as well as from the fact that it is rife with division across many pretty isolated islands. As a way out, the present paper offers a thorough and in‐depth review of the clustering domain as a whole under the form of an outline map based on an overarching conceptual framework and a common language. With this framework we wish to contribute to structuring the clustering domain, to characterizing methods that have often been developed and studied in quite different contexts, to identifying links between methods, and to introducing a frame of reference for optimally setting up cluster analyses in data‐analytic practice.This article is categorized under:
Technologies > Structure Discovery and Clustering