bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasomics in liver cancer: Developing a radiomics model for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma using contrast-enhanced ultrasound
Authors: Su Li-Ya , Xu Ming , Chen Yan-Lin , Lin Man-Xia , Xie Xiao-Yan 
Published: July 2024

BACKGROUND
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) represent the predominant histological types of primary liver cancer, comprising over 99% of cases. Given their differing biological behaviors, prognoses, and treatment strategies, accurately differentiating between HCC and ICC is crucial for effective clinical management. Radiomics, an emerging image processing technology, can automatically extract various quantitative image features that may elude the human eye. Reports on the application of ultrasound (US)-based radiomics methods in distinguishing HCC from ICC are limited.
AIM
To develop and validate an ultrasomics model to accurately differentiate between HCC and ICC.
METHODS
In our retrospective study, we included a total of 280 patients who were diagnosed with ICC (n = 140) and HCC (n = 140) between 1999 and 2019. These patients were divided into training (n = 224) and testing (n = 56) groups for analysis. US images and relevant clinical characteristics were collected. We utilized the XGBoost method to extract and select radiomics features and further employed a random forest algorithm to establish ultrasomics models. We compared the diagnostic performances of these ultrasomics models with that of radiologists.
RESULTS
Four distinct ultrasomics models were constructed, with the number of selected features varying between models: 13 features for the US model; 15 for the contrast-enhanced ultrasound (CEUS) model; 13 for the combined US + CEUS model; and 21 for the US + CEUS + clinical data model. The US + CEUS + clinical data model yielded the highest area under the receiver operating characteristic curve (AUC) among all models, achieving an AUC of 0.973 in the validation cohort and 0.971 in the test cohort. This performance exceeded even the most experienced radiologist (AUC = 0.964). The AUC for the US + CEUS model (training cohort AUC = 0.964, test cohort AUC = 0.955) was significantly higher than that of the US model alone (training cohort AUC = 0.822, test cohort AUC = 0.816). This finding underscored the significant benefit of incorporating CEUS information in accurately distinguishing ICC from HCC.
CONCLUSION
We developed a radiomics diagnostic model based on CEUS images capable of quickly distinguishing HCC from ICC, which outperformed experienced radiologists.
Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer
Authors: Ono Takashi , Sato Hiraku , Miyasaka Yuya , Hagiwara Yasuhito , Yano Natsuko , Akamatsu Hiroko , Harada Mayumi , Ichikawa Mayumi 
Published: July 2024

BACKGROUND
Carbon ion radiotherapy (CIRT) is currently used to treat prostate cancer. Rectal bleeding is a major cause of toxicity even with CIRT. However, to date, a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been shown. Similarly, the clinical risk factors for rectal bleeding were absent after 12 fractions of CIRT.
AIM
To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate cancer.
METHODS
Among 259 patients who received 51.6 Gy [relative biological effectiveness (RBE)], in 12 fractions of CIRT, 15 had grade 1 (5.8%) and nine had grade 2 rectal bleeding (3.5%). The dose-volume parameters included the volume (cc) of the rectum irradiated with at least x Gy (RBE) (Vx) and the minimum dose in the most irradiated x cc normal rectal volume (Dx).
RESULTS
The mean values of D6cc, D2cc, V10 Gy (RBE), V20 Gy (RBE), V30 Gy (RBE), and V40 Gy (RBE) were significantly higher in the patients with rectal bleeding than in those without. The cutoff values were D6cc = 34.34 Gy (RBE), D2cc = 46.46 Gy (RBE), V10 Gy (RBE) = 9.85 cc, V20 Gy (RBE) = 7.00 cc, V30 Gy (RBE) = 6.91 cc, and V40 Gy (RBE) = 4.26 cc. The D2cc, V10 Gy (RBE), and V20 Gy (RBE) cutoff values were significant predictors of grade 2 rectal bleeding.
CONCLUSION
The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.
Incidence of exclusive extrapelvic skeletal metastasis in prostate carcinoma on bone scintigraphy
Authors: Singh Parneet , Agrawal Kanhaiyalal , Rahman Ashique , Singhal Tejasvini , Parida Girish Kumar , Gnanasegaran Gopinath 
Published: July 2024

BACKGROUND
Bone is one of the common sites of metastasis from prostate carcinoma. Bone scintigraphy (BS) is one of the most sensitive imaging modalities currently used for bone metastatic work-up. Skeletal metastasis in prostate carcinoma commonly involves pelvic bones but rarely involves extrapelvic-extraspinal sites.
AIM
To retrospectively analyze the BS data to determine the pattern of skeletal metastases in the prostate carcinoma.
METHODS
This retrospective observational study involves patients with biopsy-proven prostate carcinoma referred for BS for staging assessment. Patients with abnormal BS were evaluated for the pattern of skeletal involvement and data were presented in descriptive format in the form of percentages.
RESULTS
A total of 150 patients with biopsy-proven prostate cancer who were referred for staging were included in the study. Thirteen of 150 patients (8.67%) had no abnormal uptake on planar images, ruling out metastatic disease. Twenty-four patients (16%) had heterogeneous uptake in the spine with distribution characteristic of degenerative disease and no scan pattern of metastatic disease. Thirty patients (20%) had multifocal uptake involving both pelvic and extra pelvic bones on planar images typical for skeletal metastasis and were considered metastatic. Eighty-three out of 150 patients (55.3%) had increased tracer uptake, which was indeterminate, thus, single photon emission computed tomography-computed tomography (SPECT-CT) was acquired, which showed 51 with metastatic disease, 31 benign lesions, and one indeterminate finding. Seven of 150 patients had exclusive pelvic bone uptake, which was found to be metastatic in 4/7 patients in SPECT-CT. Fifty six out of 150 patients showed exclusive extrapelvic tracer uptake, of which only 3 had vertebral metastatic disease. None of the patients with increased uptake exclusively in the extrapelvic-extraspinal location was metastatic.
CONCLUSION
The incidence of exclusive extrapelvic skeletal metastatic disease in prostate carcinoma is 2% (excluding one patient with indeterminate findings). Further, none of the patients in the current study had exclusive extrapelvic-extraspinal metastasis. Thus, exclusive extrapelvic-extraspinal focal abnormality on planar BS carries a very low probability of metastatic disease and hence, further imaging or SPECT-CT can be safely avoided in such cases.
Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome
Authors: Li Si-Qi , Min Dong-Yu , Jiang Jun-Wen , Li Xiao-Ying , Yang Xu-Na , Gu Wen-Bo , Jiang Jia-Hui , Chen Li-Hao , Nan Han , Chen Ze-Yu 
Published: July 2024

BACKGROUND
Chronic heart failure is a complex clinical syndrome. The Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure; however, the underlying molecular mechanism is still not clear.
AIM
To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart failure.
METHODS
The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. The target genes of chronic heart failure were searched in the Genecards database. The target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drug-disease targets, which were then used to construct a key chemical component-target network using Cytoscape 3.7.2 software. The protein-protein interaction network was constructed using the String database. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape database. Finally, our previously published relevant articles were searched to verify the results obtained via network pharmacology.
RESULTS
A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified, of which quercetin, kaempferol, 7-methoxy-2-methyl isoflavone, formononetin, and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3, MAPK3, AKT1, JUN, MAPK1, TP53, TNF, HSP90AA1, p65, MAPK8, MAPK14, IL6, EGFR, EDN1, FOS, and other proteins. The pathways identified by KEGG enrichment analysis include pathways in cancer, IL-17 signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, calcium signaling pathway, cAMP signaling pathway, NF-kappaB signaling pathway, AMPK signaling pathway, etc. Previous studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α, IL-6, MAPK, cAMP, and AMPK pathways to affect the mitochondrial structure of myocardial cells, oxidative stress, and energy metabolism, thus achieving the therapeutic effects on chronic heart failure.
CONCLUSION
The Chinese medicine compound preparation Jianpi Huatan Quyu recipe exerts therapeutic effects on chronic heart failure possibly by influencing the mitochondrial structure of cardiomyocytes, oxidative stress, energy metabolism, and other processes. Future studies are warranted to investigate the role of the IL-17 signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, and other pathways in mediating the therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure.
Strategi Pendidikan Agama Kristen Dalam Menanamkan Sikap Moderasi Beragama di Sekolah Tinggi Teologi
Authors: Novi Kristiani Tahalele  , Seli Antonia Tagu Sunga  , Bazahati Laia  , Triyanto Yoel , Wahyu A. Rini  
Published: July 2024

Religious moderation is an attitude and way of thinking that upholds the values of justice, balance, straightness, tolerance, priority, civility, and creativity in understanding and practicing religious teachings. Religious moderation is considered important and is one of the values that must be instilled in all students in Indonesia, including those at the Jakarta School of Ecumenical Theology. Students are seen as crucial in learning the value of religious moderation, especially in light of recent issues arising from political conflicts between Israel and Palestine, which are often linked to religion. This has become a sensitive issue that may fuel conflicts among religious communities, emphasizing the need for the frequent incorporation of moderation education. The purpose of this research is to understand the implementation of Christian Religious Education strategies in instilling a stance of religious moderation at the Jakarta School of Ecumenical Theology. The research method employed is qualitative, utilizing observation and interview techniques. The Jakarta School of Ecumenical Theology has already instilled the values of religious moderation in lectures conducted during a single session. This serves as a specific strategy within Christian Religious Education to instill the values of religious moderation, aiming to create a harmonious and peaceful environment.
Computational investigation and biological activity of selected Schiff bases
Authors: Oladipo Segun , Adeleke Adesola A. , Badeji Abosede A. , Babalola Katherine I. , Labulo Ayomide H. , Hassan Ibrahim , Yussuf Sadiq T. , Olalekan Samuel O. 
Published: July 2024

Two Schiff bases, (E)-N-(4-bromophenyl)-1-(2,6-dichlorophenyl)methanimine (S1) and (E)-4-(((4-bromophenyl)imino)methyl)phenol (S2) were synthesized and elucidated using basic spectroscopic methods such as Fourier-transform-infrared, Ultraviolet-visible as well as 1H & 13C-NMR while purity of the compounds was ascertained by the means of elemental analysis. The stability, chemical reactivities and electronic properties of S1 and S2 were evaluated using Density Functional Theory (DFT). Energy band gap (?E) of S1 and S2 are 2.81 eV and 3.02 eV respectively and this inferred that S1 is more reactive as well as less stable than S2. The Molecular electrostatic potential (MEP) mapping evaluation showed that both S1 and S2 are having more of the yellow, green and red region than the blue region, signifying that these structures are prone to electrophilic attack. The compounds were screened against one Gram-negative (Staphylococcus aureus) and two Gram-positive bacteria (Klebsiella pneumoniae and Psedomonas aeruginosa) to evaluate their antibacterial potential. S1 as well as S2 showed antibacterial potential against Staphylococcus aureus and exhibited less of no activity against Klebsiella pneumoniae and Escherichia coli. In silico studies of S1 and S2 against Staphylococcus aureus was carried out and the outcomes corroborate with experimental findings. Pharmacological evaluation of S1 and S2 showed that both compounds exhibited less violation of Lipinski’s rule of five (Ro5) which pose them to be less toxic and orally available.
PENDIDIKAN PLURALISME DALAM PERSPEKTIF GUS DUR DAN SYAFI’I MA’ARIF
Authors: Khoiruddin Ahmad , Khalilurrahman  , Prasetiya Benny 
Published: July 2024

Gus Dur (KH Abdurrahman Wahid) and Syafi'i Ma'arif, as Muslim intellectuals who came from Nahdlatul Ulama and Muhammadiyah, had very valuable ideas, including in the context of pluralist education. Gus Dur and Syafi'i Ma'arif's perspective on pluralism education reflects a deep understanding and values such as tolerance, diversity and respect for differences in society. Here are some important aspects in both views. In Gus Dur's perspective, the main focus lies on tolerance and diversity. He emphasized the importance of equality and understanding religion as the foundation for a harmonious life. On the other hand, Syafi'i Ma'arif focuses on multicultural education and humanist education. Although there are differences in approach between the two, there are similarities in their views. These two figures have the common goal of avoiding conflict, as well as building awareness and integration of religious values in society. Thus, Gus Dur and Syafi'i Ma'arif's approach to pluralistic education creates a strong foundation for realizing social harmony and respect for diversity
Keywords: Pluralism Education; Gus Dur's Pluralism Education; Syafi'i Ma'arif's Pluralism Education.
Increase in Purchase Intention through Source Credibility, Recommendation Credibility, and Psychological State: Brand Awareness Mediates
Authors: Supriyadi Ari , Rahmat Syah Tantri Yanuar 
Published: July 2024

Research Aims: The purpose of this study was built to determine the positive effect of increasing Purchase Intention through Source Credibility, Recommendation Credibility, and Psychological State: Brand Awareness being the mediation
Design/methodology/approach: The purposive sampling method was designed in this study with 389 online customers from several well-known skincare brands in Indonesia. The data was analyzed using the Structural Equation Model (SEM) with SmartPLS 3.0
Research Findings: The findings of this study being Source Credibility has a positive effect on Recommendation Credibility. Then Recommendation Credibility has a positive effect on Psychological State and Brand Awareness. Furthermore, Recommendation Credibility, Psychological State, and Brand Awareness have a positive effect on Purchase Intention. Brand Awareness manages to be a mediating effect between Recommendation Credibility and Purchase Intention. Managerial implications in this study for researchers and practitioners should not underestimate the importance of social media, establish a cooperative relationship between companies and celebrities for continuity, and know the importance of pre-purchase psychological states
Theoretical Contribution/Originality: The study contributes to the existing literature by providing insights into the complex interplay of factors influencing Purchase Intention. It highlights the importance of social media and the role of celebrities in marketing strategies, as well as the significance of pre-purchase psychological states and the mediating effect of Brand Awareness.
Keywords: Source Credibility, Recommendation Credibility, Psychological State, Brand Awareness, Purchase Intention
Influence Of Organizational Fairness, Organizational Culture and Job Satisfaction On Organizational Commitment
Authors: Tegar Hidayat Tegar Hidayat , Subiyanto Didik , Septyarini Epsilandri 
Published: July 2024

Research Aims: This study aims to analyze the effect of organizational justice, organizational culture, and job satisfaction on organizational commitment among community members of Kampung Batik Giriloyo, Wukirsari, Bantul, DIY.
Design/methodology/approach: This study is a quantitative research, by examining the cause-and-effect relationship of the variables Organizational Justice, Organizational Culture, Job Satisfaction, and Organizational Commitment, with 42 respondents. Data was collected using a questionnaire using a Likert scale of 1 to 5, where 1 indicated "strongly disagree" and 5 indicated "strongly agree". The collected data is processed with the SPSS program.
Research Findings: 1) there is a positive and significant influence between organizational fairness and organizational commitment. (2) There is a positive and significant influence between organizational culture on organizational commitment. (3) There is a positive and significant influence between job satisfaction and organizational commitment. (4) There is a simultaneous positive and significant influence between organizational fairness, organizational culture, and job satisfaction on organizational commitment.
Theoretical Contribution/Originality: This integrated strategy includes a holistic approach that aims to simultaneously improve fairness, culture, and job satisfaction, which in turn will increase organizational commitment. By adopting this strategy, Paguyuban Kampung Batik Giriloyo can ensure long-term sustainability and success through the creation of an environment that supports and empowers each of its members.
Keywords: Organizational Justice; organizational culture; job satisfaction; Organizational Commitment
Posisi Media Online Tempo.co dan Kompas.com Pada Pemberitaan Kemungkinan Kaesang Bawa PSI Lolos Ambang Batas Parlemen untuk Pemilu 2024
Authors: Putri Rizsa Aulia , Arindawati Weni A. , Budhiharti Tri Widya 
Published: July 2024

Having failed in the 2019 elections due to a lack of votes, it is now the turn of the Indonesian Solidarity Party (PSI), finalizing its strategy to pass the parliamentary threshold. One of the ways PSI is doing this is by inviting Kaesang to join and make him the party chairman. With his electability as the son of the Indonesian president, Kaesang is believed to be able to deliver PSI to Senayan and sit in the Kursi DPR in the 2024 elections. However, will Kaesang really be able to bring PSI to Senayan.
This study aims to explore how the news framing formed by Tempo.co and Kompas.com on the possibility of Kaesang bringing PSI to Senayan. Tempo.co and Kompas.com were chosen because these two media are quite active in reporting Kaesang from different perspectives. This research combines descriptive qualitative methodology with a framing analysis method based on the Zhongdang pan Gerald kosicki model taken from each Tempo.co and Kompas.com news coverage on September 27, 2023. The results of this study show that Tempo.co considers that the presence of Kaesang as chairman is able to deliver PSI through parliament. While Kompas.com, this media actually doubts Kaesang in leading the party. It considers that Kaesang will not be able to bring PSI without the help of people who are experienced and understand politics.
O‘ZBEKISTON AHOLISINING ROSSIYA FEDERATSIYASIDA MEHNAT MUHOJIRLIGI TARIXI
Authors: Abduxamidov Islombek 
Published: July 2024

Maqolada o‘zbekistonliklar xususan, Farg‘ona vodiysi viloyatlari aholisining Rossiya Federatsiyasidagi mehnat muhojirligi tarixi turli adabiyotlar, davriy matbuot nashrlari shuningdek, Kambag‘allikni qisqartirish va bandlik vazirligi huzuridagi Tashqi mehnat migratsiyasi agentligining idoraviy arxivi materiallari asosida tahlil qilingan. Shuningdek, Rossiya Federatsiyasidagi o‘zbekistonlik mehnat muhojirlarining tashkiliy-huquqiy masalalarini o‘z vaqtida yo‘lga qo‘yilmasligi natijasida migratsiyaning salbiy oqibatlari paydo bo‘lganligi yoritib o‘tilgan.
EKSISTENSI ULAMA PEREMPUAN DALAM BUDAYA PARTHIARKHI DI PESANTREN: STUDI ULAMA PEREMPUAN DI KOTA JEMBER
Authors: Elisa Dourothun Nafis El Adibah  , Syafril Wicaksono  , M. Khoirul Hadi al Asy'ari  
Published: July 2024

Berdasarkan kejadian sosiologis di beberapa pesantren, budaya patriarki masih mendominasi. Meskipun pesantren memberikan beberapa kemungkinan bagi perempuan untuk mendapatkan kesempatan yang sama dalam pendidikan pesantren, namun hal tersebut tampaknya tidak mempengaruhi pengertian struktur sosial sebagai bagian dasar interaksi di dunia pesantren. Akibatnya, tidak bisa memuat penafsiran agama, adat istiadat, dan nilai-nilai yang ada di pesantren. Sehingga, pesantren gagal memenuhi harapan perempuan. Tujuan dari penelitian ini adalah untuk melihat keberadaan ulama perempuan dalam konteks budaya patriarki di pesantren di Kota Jember. Penelitian ini merumuskan dua pertanyaan yaitu: pertama, bagaimana respon dan negosiasi keberadaan ulama perempuan dalam budaya patrikiarki di pesantren kota Jember?. Kedua, Bagaimana posisi dsn relasi keberadaaan ulama perempuan dalam budaya patrikiarki di pesantren kota Jember?. Penelitian ini menggunakan metodologi penelitian empiris, serta pendekatan studi kepustakaan berdasarkan data deskriptif kualitatif. Berdasarkan temuan penelitian ini, kehadiran ulama perempuan dalam budaya patriarki di pesantren memiliki implikasi yang kompleks bagi tumbuh kembangnya pesantren itu sendiri. Studi ini menemukan bahwa, meskipun ada banyak hambatan dalam pendidikan agama dan peran kepemimpinan, ulama perempuan memainkan peran penting dalam pembelajaran agama dan pengembangan karakter di pesantren. Ulama perempuan juga memberikan contoh dalam berperan aktif di masyarakat dan memberikan sudut pandang baru mengenai interpretasi agama. Tetapi, terdapat beberapa tantangan bagi ulama perempuan di pesantren berupa adanya kendala stuktural dalam sistem pendidikan, ketidaksetaraan gender. Berdasarkan hal tersebut, eksistensi ulama perempuan dipesantren kota Jember memberikan makna perjuangan peran perempuan terutama dilingkup pesantren dengan tantangan yang ada. Sehingga kajian ini memperluas kesetaraan gender dan reformasi budaya dipesantren.