bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les réunions et leurs épisodes formatifs : l’apprentissage d’un savoir professionnel dans l’interaction sociale
Authors: Lefebvre Augustin 
Published: July 2024

Cet article prend appui sur un corpus vidéo recueilli lors de réunions entre des travailleurs sociaux, des bénévoles et des usagers au sein d’une association parisienne dont la mission est de fournir des logements à des personnes précaires. Les réunions enregistrées sont tenues dans le cadre de l’évaluation interne de l’association, au cours de laquelle les travailleurs sociaux passent en revue et évaluent leurs pratiques professionnelles, l’enjeu étant d’identifier les aspects qu’ils pourraient améliorer. Dans la perspective de l’analyse conversationnelle (Sacks, Schegloff et Jefferson 1974), cet article propose l’étude de ce que l’on appellera des épisodes formatifs – c’est-à-dire des occasions non planifiées d’apprentissage – lors de réunions dont les participants appartiennent à des catégories socio-professionnelles hétérogènes, caractérisées par des savoirs et des expériences asymétriques. Un épisode formatif peut être soit hétéro-initié – l’occasion d’apprentissage émerge après une correction initiée par un autre participant – soit auto-initié – l’occasion d’apprentissage est générée par le participant identifié comme non-professionnel. L’épisode formatif repose alors sur la capacité du participant à ajuster son savoir spécifique aux attentes d’une activité professionnelle.
La scénographie dans l’œuvre d’Herbert Bayer : les expositions d’architecture, 1923-1938
Authors: Vanryb Anne Monier 
Published: July 2024

Élève modèle du Bauhaus, Herbert Bayer expérimente et exerce dans un grand nombre de champs artistiques, tour à tour photographe, peintre, typographe, publicitaire, scénographe, architecte, sculpteur, designer, urbaniste ou land-artist, toujours animé par l’idée que le designer n’est jamais inférieur, du point de vue artistique, à ce que l’on peut appeler « l’artiste libre ». Bayer n’est pas pour autant un indécis ou un touche-à-tout. Se diversifier à l’extrême ne signifie pas pour lui se disperser, il s’agit plutôt de réunir les compétences pour bâtir une œuvre d’art totale, véritablement capable d’agir sur le spectateur. Les réalisations scénographiques de Bayer, qui apportent des innovations décisives pour le développement de la discipline, scandent comme autant d’étapes sa quête vers une œuvre d’art globale.Au Bauhaus, où il étudie entre 1921 et 1925, puis enseigne entre 1925 et 1928, Bayer acquiert un ensemble de connaissances qui seront déterminantes pour sa pratique de la scénographie, et les met en pratique dans l’exposition « Staatliches Bauhaus in Weimar » de 1923, qui comporte un volet dédié à l’architecture contemporaine. Il s’inscrit ainsi dans un mouvement de renouveau de la Museumsinszenierung dans l’Allemagne de l’entre-deux-guerres. En 1930, Bayer organise, avec Gropius, Marcel Breuer et László Moholy-Nagy la participation du Werkbund au XXe Salon de la Société des artistes décorateurs. Différents espaces d’un Wohnhotel sont exposés, mettant ainsi en avant l’impact social de l’architecture. La scénographie, en donnant l’impression de visiter un véritable immeuble d’habitation collective et non sa transposition dans une exposition d’architecture, est primordiale. Cette étape est pour Bayer l’occasion pour lui de théoriser son approche de l’accrochage, mais également d’ancrer le rôle du scénographe dans l’organisation d’une exposition, en se chargeant également du catalogue et de l’affiche. Il participe l’année suivante à la « Deutsche Bauausstellung », importante exposition d’architecture berlinoise qui rassemble l’ensemble des acteurs du bâtiment. Il s’agit de sa dernière réalisation dans ce domaine. Dans les années 1930 et 1940, Bayer scénographiera des expositions de propagande, pour l’Allemagne, puis pour les États-Unis après son émigration en 1938. Herbert Bayer a ainsi développé, tout au long du XXe siècle, une approche de la scénographie basée sur l’expérience du visiteur, novatrice à son époque et riche en ramifications actuelles.
Diadoque de Photicé : l’invocation continue du nom de Jésus au prisme de la grâce
Authors: Depraz Natalie 
Published: July 2024

Dans cette présentation phénoménologique de la théologie anthropologique de Diadoque de Photicé, mon objectif premier est de montrer combien ce saint fut, selon la belle formulation de Jean Meyendorff, « l'un des grands popularisateurs de la spiritualité du désert dans le monde byzantin ». L’expérience spirituelle du goût de Dieu n’est en rien l’apanage d’un cercle d’initiés ni réservée aux moines, parfois idéalisés comme des athlètes de Dieu : c’est la vie tout entière selon l’esprit qui est en jeu, tout l’itinéraire de la foi au quotidien, et pas seulement un état de prière illuminé. C’est pourquoi Diadoque, aujourd’hui encore, peut intéresser. On comprend alors combien pour Diadoque ce chemin expérimental et expérientiel de la vie humaine ne distingue plus, à terme, grâce divine et effort humain. Non qu’il faille confondre les parts respectives de Dieu et de l’humain, mais parce que, comme on le verra, la grâce étant donnée à l’homme dès le baptême, elle se met à opérer de plus en plus, à mesure que l’être humain pratique, fait exercice (askesis), effort (epimeleia), à savoir entre toujours plus, et toujours mieux surtout, dans l’invocation du nom de Jésus. Ainsi, grâce divine et effort humain, œuvrant ensemble, entrent spontanément dans une sorte de danse où ils deviennent à mesure un en deux.
Glycogenic acanthosis of the tongue
Authors: Gotur Suhasini P. , Kamarthi Nagaraju , Wadhwan Vijay 
Published: July 2024

ABSTRACT
Glycogenic acanthosis (GA) is a benign lesion characterized by elevated, small, white plaques commonly detected in the esophageal mucosa. To date, only 6 cases have been reported in the English literature documenting its involvement in the oral cavity. Herein we report a case of large GA on the ventrolateral aspect of the tongue in a 42-year-old male (third case reported on the tongue). Histologically, the lesion was characterized by acanthotic squamous epithelium with glycogen-rich, clear cells located in the upper layers of the epithelium. Since the oral presentation of GA is very rare, it is necessary to document more cases to clarify the clinical features, biological behavior, and management of GA in the future.
Determination of target genes for classified molecular subtypes of triple-negative breast cancer form microarray gene expression profiling: An integrative in silico approach
Authors: Ray Manisha , Banik Suranjana , Sable Mukund N. 
Published: July 2024

ABSTRACT

Background:
Highly heterogeneous triple-negative breast cancer (TNBC) has tough clinical features, which were gradually solving and improving in diagnosis by the molecular subtyping of TNBC.

Aim:
Presently, this study was focused on analyzing the genetic makeup of TNBC subtypes.

Settings and Design:
This study explored the MicroArray expression profiling of differentially expressed genes in molecular subtypes BL1, BL2, IM, luminal androgen receptor, M, and mesenchymal stem-like of TNBC by analyzing the Gene Expression Omnibus dataset GSE167213. Various gene ontologies-based protein–protein interaction (PPI) networks were subtyped TNBC genes. The effect of genetic alteration on TNBC cases was also interpreted.

Materials and Methods:
The MicroArray gene expression profiling was done through R programming and subjected to functional annotation through the database for annotation, visualization, and integrated discovery. The PPI networking of functionally associated genes was interpreted by STRING. The survival analysis was done through cBioPortal.

Statistical Analysis Used:
The t-test was used through R programming to generate the P values for a test of the significance of expressed genes.

Results:
A total of 54,613 significant probes were analyzed in the TNBC MicroArray dataset. The functional PPI networks of BL1, BL2, and IM upregulated genes showed significant associations. The survival analysis of differentially expressed genes showed the significant prognostic effect of 32 upregulated genes of different subtypes on TNBC cases with genetic alterations, whereas the remaining genes showed no significant effects.

Conclusion:
The output of the present study provided significant target gene panels for different TNBC subtypes, which would add an informative genetic value to TNBC diagnosis.
An immunohistochemical study of diffuse large B-cell lymphoma with molecular subtyping based on Hans algorithm
Authors: Ananthamurthy Anuradha , Murali Megha 
Published: July 2024

ABSTRACT

Introduction:
Diffuse large B-cell lymphoma (DLBCL) is the most common type of B-cell lymphoma accounting for about 40% of all lymphomas. The international prognostic index (IPI), which relies on clinical and laboratory parameters, is used as a prognostic tool in DLBCL. In this study, we have included cases of DLBCL not otherwise specified (NOS) type to test the usefulness of the biological subclassification of DLBCL by immunohistochemistry (IHC) using the Hans algorithm into the germinal center B-like (GCB) type and nongerminal center (non-GCB) type. We correlated the subtypes with the demographics, site of involvement, IPI scores, and stage.

Objectives:
1. To study the immunohistochemical profile of DLBCL. 2. To classify patients with DLBCL into germinal center and nongerminal center subtypes. 3. To review the clinical presentations, clinical staging, and follow-up data in cases of DLBCL.

Materials and Methods:
A total of 152 cases of DLBCL reported from January 2010 to March 2018 were included in this study. Clinical data, treatment details, and follow-up were reviewed. Apart from the routine IHC markers for DLBCL, additional markers CD10, BCL6, and MUM 1 were performed to classify DLBCL into GCB type and non-GCB type using the Hans algorithm.

Results:
The median age of presentation was 53 years with male-to-female ratio of 2:1. Most of the patients presented with nodal involvement (56.6%); cervical lymph node is the most common site (46.5%). The majority of the patients presented in Ann Arbor stage 1 (44.8%). According to the international prognostic index, 34.8% had a score of 3 (high intermediate). After IHC studies, GCB subtype (51.5%) of DLBCL emerged as more common than non-GCB type (48.5%). The two subtypes differed significantly with regard to sex (i.e. GCB type was more common in males and non-GCB type in females) and showed no significance with regard to any of the other clinical features and prognostic parameters evaluated.

Conclusion:
Our study showed that IHC was a useful tool to subclassify DLBCL into GCB and non-GCB subtypes and may be easily incorporated in routine clinical practice.
Retrospective study on the distribution of hemoglobinopathies in Karnataka—A laboratory experience
Authors: Putchen Deepalakshmi D. , Kulkarni Swathi , Nanjundarao Suma S. , Bhat Dattamoorti G. , Venkatachala Pradeep K. , Prasad Sujay R. 
Published: July 2024

ABSTRACT

Aims:
The importance of screening for hemoglobinopathies is well-documented in India. However, information on the distribution of hemoglobinopathies in Karnataka is lacking. The present study focuses on determining the spectrum of hemoglobinopathies for various districts of Karnataka.

Materials and Methods and Results:
A retrospective analysis of samples registered for hemoglobinopathies for a period of 5 years (2017–2021) was carried out. A total of 17066 records registered only from the Karnataka region, were anonymized and retrieved. The data included gender, age, district, and results of the tests. The results were based on complete blood count, peripheral smear, and capillary electrophoresis (CE) pattern. The data were revalidated by pathologists, and the unambiguous data were analyzed for the study. One-fourth of the records (25%) showed abnormal hematological parameters. The number of female records (66%) was twice that of males and both genders showed higher distribution of thalassemia, followed by variants and double heterozygotes (DH). Several cases of thalassemia major were identified below the age of 17 years. The majority of thalassemia cases were β thal and 93% of them were β thal trait. Among the variants, HbS was more prevalent than HbE. Among the districts, Hassan had a 35.2% thal, Mysuru had a 7.2% variant, and Chitradurga had a 5.5% DH. Thalassemia, variants, and DH were distributed across several districts of Karnataka to various levels.

Conclusion:
The comprehensive retrospective analysis of the spectrum of hemoglobinopathies in various districts of Karnataka serves as evidence to carry out a prospective study on population screening where the incidence of thalassemia and structural variants is high.
The Scientific Evidence for Lumbar Total Disk Replacement Surgery
Authors: Blumenthal Scott L. , Ohnmeiss Donna D. 
Published: July 2024

AbstractLumbar total disk replacement (TDR) has been in use since the 1980s, yet its adoption has not paralleled that of hip or knee arthroplasty or cervical TDR, which was introduced years after lumbar arthroplasty. If the lack of adoption is related to concerns about the safety and/or effectiveness of these implants, these issues have been extensively addressed in the literature. This narrative review aims to concisely report on the evidence published in the peer-reviewed literature related to lumbar TDR. Literature was identified from online databases such as PubMed, Scopus, and ScienceDirect, supplemented by the authors’ institution’s comprehensive database of TDR articles. By the end of 2023, there were at least 816 articles published on lumbar TDR covering all aspects of this technology, including biomechanics, clinical outcome, radiographic outcome, safety as assessed by re-operations and complications, and the cost related to this treatment intervention. Consistently, the evidence indicates that TDR yields outcomes similar or superior to fusion for treating painful disk degeneration unresponsive to non-operative care in appropriately selected patients.
Decoding the Genetic Threads of Disc Degeneration
Authors: Biswas Amitabh , Garg Bhavuk 
Published: July 2024

Abstract
Degenerative disc disease (DDD) is a prevalent musculoskeletal disorder characterized by the progressive degeneration of intervertebral discs, often leading to chronic low back pain and disability. While the etiology of DDD is multifactorial, genetic factors play a significant role in disease susceptibility and progression. This review provides a comprehensive overview of the genetic aspects of DDD, summarizing previously reported genes and variations associated with the disease. Through an analysis of animal studies and molecular pathways implicated in disc degeneration, including the lipid kinase phoshoinositide-3-kinase signaling pathway (PI3K-Akt), mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway (MAPK-ERK), Wingless-related integration (Wnt)/β-catenin, Sonic Hedgehog (Shh), and mammalian target of rapamycin (mTOR) pathways, this review elucidates the intricate interplay between genetic factors and disc pathology. Several candidate genes have been identified in association with DDD, including those involved in extracellular matrix regulation, inflammation, and cell signaling. Genome-wide association studies have further expanded our understanding of the genetic architecture underlying DDD, revealing novel susceptibility loci and pathways. Animal studies utilizing genetically modified models have provided valuable insights into the molecular mechanisms driving disc degeneration and have validated the relevance of specific genetic pathways in disease pathogenesis. Understanding the genetic basis of DDD holds promise for identifying individuals at risk, developing predictive biomarkers, and informing personalized treatment approaches. Furthermore, elucidating the molecular pathways involved in disc degeneration may lead to the identification of novel therapeutic targets for DDD management. Overall, this review consolidates current knowledge on DDD genetics and pathways, providing a foundation for future research endeavors aimed at unraveling the intricate genetic mechanisms underlying this prevalent musculoskeletal disorder.
Comparison of Ultrasound, Trucut Biopsy, and Their Combined Accuracy with Postoperative Biopsy in Breast Lumps
Authors: Sundaram Sendhil Sudarsan , Kumar S. Vinoth , Rajasekar AV Dinesh , Nagam Amarnath 
Published: July 2024

Abstract

Background:
Breast lumps, a concern often surrounded by cultural taboos in India, demand effective diagnostic strategies, particularly with the prevalence of breast malignancy on the rise.

Objectives:
The primary objective is to determine the sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy of ultrasound and trucut biopsy concerning postoperative biopsy in breast lumps.

Subjects and Methods::
The study conducted at MGMCRI, Pondicherry, was a prospective diagnostic accuracy study involving 36 patients presenting with breast lumps. Participants were selected based on inclusion criteria of being over 18 years old and consenting to undergo both ultrasound and trucut biopsy, followed by definitive surgery. Exclusion criteria included patients unwilling to undergo surgery. Data were collected through detailed clinical examinations, ultrasound, and trucut biopsy, followed by histopathological examination after surgery. Statistical analysis involved calculating sensitivity, specificity, positive predictive value, negative predictive value, and overall diagnostic accuracy, with significant results considered at P < 0.05.

Results:
Analysis across various age groups revealed a correlation between benign and malignant diagnoses made by ultrasound and trucut biopsy, demonstrating high diagnostic effectiveness for both methods. The sensitivity for both ultrasound and trucut biopsy was 100%, indicating excellent detection of true-positive cases. Specificity differed between the two, with ultrasound achieving 93.33% and trucut biopsy reaching 100%, highlighting its superior precision in identifying nonmalignant cases. Additionally, both positive and negative predictive values were exceptionally high, underscoring the reliability of these diagnostic tools in clinical practice.

Conclusions:
Ultrasound and trucut biopsy proved complementary and vital in diagnosing breast lumps, showcasing substantial correlation with postoperative histopathological outcomes. The study underscores the importance of these diagnostic methods in guiding appropriate surgical interventions for accurate diagnosis and management of breast lumps.
Agrochemical use in Farming Practices and Risk Factors for Kidney Disease among Dwellers of Rural Farming Communities in South-West Nigeria
Authors: Raji YR , Ajayi SO , Michael OS , Adewole D , Akande T , Abiola BI , Aminu OO , Efuntoye OO , Olugbenga-Bello A , Arije A 
Published: July 2024

Background:
The outlook of chronic kidney disease (CKD) in low-and-medium-income-countries is poor. Modern farming practices in Nigeria are becoming increasingly associated with the use of herbicides and pesticides.

Aim:
The study aimed to evaluate agrochemical use in farming practices and risk factors for kidney disease among dwellers of rural farming communities in South-West Nigeria.

Methods:
This was a cross-sectional survey of adult dwellers of an agrarian rural farming community in South-West Nigeria. Participants provided information on demographics, lifestyles, knowledge, and awareness of risk factors for kidney disease, and the use of agrochemicals in farming practice. Anthropometric measurements and blood pressure values were obtained while blood and spot urine were collected for random blood glucose, serum creatinine, urinalysis, and albumin-creatinine ratio.

Results:
A total of 572 rural dwellers were enrolled in the study, with a mean age of 49.9 ± 17.5 years while 39.3% were male and 88.9% engaged in active farming. The prevalence of traditional risk factors for kidney disease was hypertension (24.3%), Diabetes mellitus (2.8%), cigarette smoking (7.5%), alcohol intake (20.8%) and herbal consumption (57.1%). The use of pesticides/herbicides was reported in 69.9%, while 25.3% did not use protective gear during its use. Proteinuria, hematuria, and reduced eGFR were observed in 29.8%, 6.1%, and 33.9% of participants, respectively.

Conclusion:
This study showed a high prevalence of herbicides and pesticide use and traditional risk factors for kidney disease, in addition to the high prevalence of markers of kidney damage among the dwellers of rural farming settlements in South-West Nigeria.
Pengaruh Motivasi Kerja, Disiplin Kerja Dan Lingkungan Kerja Terhadap Kinerja Pegawai Di Kecamatan Kebomas Kabupaten Gresik
Authors: Barri Ziko Malifon Ahmad Al , Krisnawati Wenti 
Published: July 2024

Keberhasilan suatu lembaga tidak hanya bergantung dengan teknologi, melainkan juga pada aspek sumber daya manusia yang dimilikinya. Suatu lembaga membutuhkan sumber daya manusia yang potensial, baik pemimpin maupun karyawan agar dapat memberikan kontribusi yang baik dan melaksanakan tugas dengan optimal untuk mencapai tujuan organisasi. Penelitian ini bertujuan untuk mengetahui pengaruh Motivasi Kerja, Disiplin Kerja, Lingkungan Kerja terhadap Kinerja Pegawai di Kecamatan Kebomas Kabupaten Gresik. Jenis penelitian ini adalah penelitian kuantitatif. Teknik analisis yang digunakan dalam penelitian adalah regresi linier berganda. Teknik alat bantu dalam penelitian ini yaitu kuisioner dilakukan dengan jumlah sampel sebayak 54 orang. Hasil penelitian ini menunjukkan bahwa variabel Motivasi Kerja dan Disiplin Kerja dapat mempengaruhi Kinerja Pegawai. Sedangkan variabel Lingkungan Kerja tidak berpengaruh terhadap Kinerja Pegawai. Penelitian ini dapat dijadikan sebagai referensi, namun bisa menggunakan metode penelitian yang berbeda dan Kecamatan Kebomas Gresik diharapkan bisa lebih meningkatkan kinerja pegawainya. Penelitian ini masih memiliki keterbatasan yaitu kelemahan variabel dikarenakan terdapat variabel lain yang tidak ada dalam model ini.
Perbedaan Keaktifan Berolahraga Pelajar Indonesia: Studi Evaluatif–Komparatif Lintas Jenjang Pendidikan
Authors: Abdilah Andi 
Published: July 2024

Terdapat fakta rendahnya tingkat kebugaran masyarakat Indonesia disebabkan karena kurangnya keaktifan dalam berolahraga. Penelitian ini bertujuan untuk mengetahui tingkat keaktifan dalam berolahraga lintas jenjang pendidikan di Indonesia. Teknik penelitian sekunder ini adalah internet mediated research (IMR). Populasi yang dikaji dalam penelitian ini adalah siswa SD, SMTP, SMTA, Sarjana, dan Magister se Indonesia tahun 2021 yang jumlahnya tak terhingga dan sampelnya sebanyak 5881 responden dan teknik pengumpulan data berupa angket/kuesioner yang bersifat snow ball sampling. Data dianalisis menggunakan tiga teknik analisis data : Uji rerata tunggal (kinerja) nilai uji (standar/kriteria/test value), Analisis Varians (Anova) dan Analisis korelasi bivariate. Hasil penelitian menunjukkan : 1) Semua pelajar dari semua jenjang pendidikan tergolong aktif berolahraga. 2) Ada perbedaan keaktifan berolahraga antara jenjang pendidikan peserta didik. Ini bisa lebih ditafsirkan berdasarkan hasil analisis korelasi, yang ternyata negative. 3) Makin tinggi jenjang pendidikan yang diikuti oleh peserta didik, semakin rendah keaktifan berolahraga mereka.