bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kohlenstoffmonoxid freisetzende Moleküle für die therapeutische CO‐Verabreichung in vivo
Authors: García‐Gallego Sandra , Bernardes Gonçalo J. L. 
Published: July 2014

AbstractDie Entwicklung Kohlenmonoxid freisetzender Moleküle (carbon‐monoxide‐releasing molecules, CORMs) als pharmazeutische Wirkstoffe stellt eine attraktive und sichere Alternative zur Verabreichung von gasförmigem CO dar. Die meisten bisher entwickelten CORMs sind Carbonylkomplexe von Übergangsmetallen. Obgleich derartige CORMs im Tierversuch bei einer Reihe von Krankheiten vielversprechende Resultate gezeitigt haben, fehlen ihnen noch die notwendigen Attribute für eine weitergehende klinische Entwicklung. Hier werden die bis jetzt entwickelten Methoden der CORM‐Selektion beschrieben. Weiterhin werden neue Erkenntnisse hinsichtlich der In‐vivo‐Reaktivität von Metall‐Carbonylkomplexen im Zusammenhang mit Methoden für den CO‐Nachweis in lebenden Zellen dargelegt. Es wird aufgezeigt, wie diese den Entwurf und die Synthese neuer CORMs vorantreiben.
Carbon‐Monoxide‐Releasing Molecules for the Delivery of Therapeutic CO In Vivo
Authors: García‐Gallego Sandra , Bernardes Gonçalo J. L. 
Published: July 2014

AbstractThe development of carbon‐monoxide‐releasing molecules (CORMs) as pharmaceutical agents represents an attractive and safer alternative to administration of gaseous CO. Most CORMs developed to date are transition‐metal carbonyl complexes. Although such CORMs have showed promising results in the treatment of a number of animal models of disease, they still lack the necessary attributes for clinical development. Described in this Minireview are the methods used for CORM selection, to date, and how new insights into the reactivity of metal‐carbonyl complexes in vivo, together with advances in methods for live‐cell CO detection, are driving the design and synthesis of new CORMs, CORMs that will enable controlled CO release in vivo in a spatial and temporal manner without affecting oxygen transport by hemoglobin.
In‐Cell NMR and EPR Spectroscopy of Biomacromolecules
Authors: Hänsel Robert , Luh Laura M. , Corbeski Ivan , Trantirek Lukáš , Dötsch Volker 
Published: July 2014

AbstractThe dream of cell biologists is to be able to watch biological macromolecules perform their duties in the intracellular environment of live cells. Ideally, the observation of both the location and the conformation of these macromolecules with biophysical techniques is desired. The development of many fluorescence techniques, including superresolution fluorescence microscopy, has significantly enhanced our ability to spot proteins and other molecules in the crowded cellular environment. However, the observation of their structure and conformational changes while they attend their business is still very challenging. In principle, NMR and EPR spectroscopy can be used to investigate the conformation and dynamics of biological macromolecules in living cells. The development of in‐cell magnetic resonance techniques has demonstrated the feasibility of this approach. Herein we review the different techniques with a focus on liquid‐state in‐cell NMR spectroscopy, provide an overview of applications, and discuss the challenges that lie ahead.
Palladium‐Catalyzed Carbonylations of Aryl Bromides using Paraformaldehyde: Synthesis of Aldehydes and Esters
Authors: Natte Kishore , Dumrath Andreas , Neumann Helfried , Beller Matthias 
Published: July 2014

AbstractCarbonylation reactions represent useful tools for organic synthesis. However, the necessity to use gaseous carbon monoxide is a disadvantage for most organic chemists. To solve this problem, novel protocols have been developed for conducting palladium‐catalyzed reductive carbonylations of aryl bromides and alkoxycarbonylations using paraformaldehyde as an external CO source (CO gas free). Hence, aromatic aldehydes and esters were synthesized in moderate to good yields.
Optisch aktive Tetrahydro‐diazixanopurine
Authors: Dreier Antje , Haller Rolf 
Published: July 2014

AbstractOptisch aktive Tetrahydro‐diazixanopurine können auf zwei Wegen aus Vorstufen, die über eine Racematspaltung gewonnen worden sind, hergestellt werden. Untersuchungen zur Konfiguration weisen auf eine R‐Konfiguration des Diazixanopurins (+)‐4 hin.
Acidity Constants of Some Hydroxy‐5β‐cholan‐24‐ammonium Ions
Authors: Fini Adamo , Roda Aldo , Bellini Anna Maria , Guarneri Mario 
Published: July 2014

AbstractAcid dissociation constants of a series of protonated hydroxy‐5β‐cholan‐24‐amines bearing different nitrogen substituents were determined potentiometrically in a dimethylsulfoxide‐water system (80:20, w/w) at 25°. Acidity constants in water were obtained by means of a linear relationship between the acidity constants in mixed solvent and pure water for protonated primary, secondary, tertiary and hydrophilic group carrying amines as reference substances. Results are briefly discussed with respect to the antimicrobial activity previously reported for the compounds described.
Lactone, 14. Mitt.: Synthese lactonverbrückter 1,1‐Diarylethylamine
Authors: Lehmann Jochen , Gossen Axel 
Published: July 2014

AbstractUmsetzung der 5,5‐Diaryl‐2(5H)‐furanone 4a–d mit überschüssigen Aminen liefert Aminoamide 5a–k, die durch Hydrolyse und Ringschluß in die gewünschten 4‐Amino‐5,5‐diaryl‐4,5‐dihydro‐2(3H)‐furanone 6a–k überführt werden.
Naturstoffchemie 110. Mitt.: Synthese des 1‐Hydroxy‐7‐methoxyacridons aus Boenninghausenia albiflora REICHB. (Rutaceae); Darstellung einiger einfacher Hydroxy‐, Methoxy‐ und Nitroacridone
Authors: Reisch Johannes , Probst Wiltrud 
Published: July 2014

AbstractÜber eine modifizierte Ullmann‐Synthese wurden die Acridone 5 dargestellt. Die 1‐Hydroxy‐7‐methoxyacridon‐Struktur für ein Alkaloid aus Boenninghausenia albiflora REICHB. konnte durch Synthese bestätigt werden.
ZNS‐wirksame Phenylpyrane: 3‐Dimethylaminomethyl‐4‐(3‐methoxyphenyl)‐tetrahydro‐4‐pyranol und ‐4‐thiopyranol
Authors: Eiden Fritz , Schmidt Michael 
Published: July 2014

AbstractDie aus dem Tetrahydropyranon 2 bzw. ‐thiopyranon 3 durch Reaktion mit dem Iminiumchlorid 4 und m‐Methoxyphenylmagnesiumbromid darstellbaren O‐ und S‐Analogen des Tramadols waren im Tierversuch deutlich analgetisch wirksam, und zwar das Oxanaloge 7 doppelt so stark wie das Thiaanaloge 8.
Syntheses of 3,6‐Substituted‐4‐(3′,4′,5′‐Substituted‐1′‐pyrazolyl)‐isoxazolo[5,4‐d]pyrimidines as Potential Antiinflammatory Agents
Authors: Adhikari Vasudeva A. , Badiger Virupax V. 
Published: July 2014

AbstractTwentyseven title compounds were synthesized from (un)substituted benzaldehydes. Their antibacterial and antifungal activities against four pathogenic bacteria and three fungi were investigated. Nine compounds were tested for antiinflammatory and analgesic activities by standard methods. A few of the compounds gave promising results.
Studies on the Synthesis of some Flavonoid Derivatives Possessing Spasmolytic Activity
Authors: Ertan Mevlüt , Ertan Rahmiye , Göker Hakan , Pindur Ulf 
Published: July 2014

Abstract3′,4′‐Dihydroxyflavone reacts with ethyl 2,3‐dibromopropanoate to form the new, substituted 1,4‐benzodioxanes 1. The regioisomers 1a and 1b were separated by crystallization and converted to the amides 2a and 2b for pharmacological testing for spasmolytic activity. The constitutions of 1 and 2 were elucidated by 400 MHz 1H‐NMR spectroscopy. In the spasmolysis test, antagonistic effects towards acetylcholine, BaCl2 and histamine were investigated. Non‐specific spasmolytic activities were detected.
2,6‐Piperidindione, 5. Mitt.: Die absoluten Konfigurationen von optisch aktiven 2,6‐Piperidindionen mit basischer Seitenkette und von einem Zwischenprodukt
Authors: Knabe Joachim , Wahl Sebastian 
Published: July 2014

AbstractDie absoluten Konfigurationen der optisch aktiven 2,6‐Piperidindione 1a–1c, 2a und 2b werden durch Korrelation ihrer CD‐Spektren mit dem des Dexetimids abgeleitet. Aus der Konfiguration von 1c ergibt sich die der Vorstufe 6, die Konfigurationen von 3, 4 und 5 folgen aus denen der Piperidindione 1a, 1b und 2b.
Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 6. Mitt.: Oligohydroxyalkandiamine
Authors: Rehse Klaus , Claus Gudrun , Leißring Susanne 
Published: July 2014

AbstractEs wurden 17 oligohydroxylierte Alkandiamine dargestellt, von denen acht die durch Collagen induzierte Thrombocytenaggregation in Konzentrationen unter 10 μmol/L halbmaximal hemmten. Sieben dieser Substanzen setzten die Gerinnungsfähigkeit von Blutplasma – dargestellt als Verlängerung der Thromboplastinzeit – in Konzentrationen zwischen 50 und 400 μmol/L auf 25 % der Norm herab. Mit 1,4‐Bisoctylaminobutan‐2,3‐diol (16) wurde eine Substanz mit starker Thrombocytenwirkung (IC50 = 9 μmol/L) jedoch ohne anticoagulante Effekte gefunden. 16 zeigt auch die durch die Einführung der Hydroxylfunktionen angestrebte Verbesserung der Wasserlöslichkeit (55 mmol/L) am deutlichsten.
Synthesen optisch aktiver Oxazolo[3,2‐a]piperidine aus Enamiden
Authors: Wanner Klaus TH. , Schünemann J. 
Published: July 2014

AbstractStereoisomere Oxazolo[3,2‐a]piperidine wurden durch intramolekulare Cyclisierung von Enamiden chiraler α‐Hydroxycarbonsäuren gewonnen und pharmakologisch untersucht.
Friedländer‐Kondensationen von o‐Aminobenzaldehyd mit Hydroxypyridinen
Authors: Reisch Johannes , Scheer Mathias 
Published: July 2014

AbstractDie Friedländer‐Kondensation von o‐Aminobenzaldehyd (1) mit 2,6‐Dihydroxypyridinen führte zu den Benzo[b][1,8]naphthyridinen 6a und 6b. Die Umsetzung von 1 mit 3‐Cyano‐2,4,6‐trihydroxypyridin (4) lieferte außer dem erwarteten 1,3(2H,5H)‐Dioxobenzo[b][1,6]naphthyridin‐4‐carbonitril (7) auch 4‐Hydroxy‐2(1H)‐oxo‐benzo[b][1,8]naphthyridin‐3‐carbonitril (8a). Neben der N‐Methylierung wurden diese Ringsysteme mit zur Cyclisation befähigten Alkylresten substituiert.
Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 7. Mitt.: Benzol‐1,3,5‐trialkanamine
Authors: Rehse Klaus , Lükens Ute , Claus Gudrun 
Published: July 2014

AbstractEs wurden 17 Benzol‐1,3,5‐trialkanamine dargestellt, von denen 9 die durch Collagen induzierte Trombocytenaggregation in Konzentrationen zwischen 2–4 μmol/L halbmaximal hemmten. Die Gerinnungsfähigkeit von Blutplasma – dargestellt als Verlängerung der Thromboplastinzeit – wurde von 7 Substanzen in Konzentrationen von ≦ 50 μmol/L auf weniger als 25 % der Norm herabgesetzt. Die Substanz 4‐(2‐Thienylbutyl)‐1,3,5‐benzol‐trimethanamin (15) zeigte die obigen antiaggregatorischen und anticoagulanten Effekte in der gleichen Konzentration von 25 μmol/L.
Asymmetrische α‐Amidoalkylierung: Synthesen enantiomerenreiner α‐substituierter Piperidine mit 1‐Camphanoyl‐1,2,3,4‐tetrahydropyridin
Authors: Wanner Klaus TH. , Kärtner Annerose 
Published: July 2014

AbstractIn einer neuartigen, asymmetrischen Synthese wird das homochirale Enamid 1 diastereoselektiv mit den Silylenolethern 5a‐c zu den Amidoalkylierungsprodukte 6/7a‐c verknüpft, die für die Gewinnung enantiomerenreiner in α‐Stellung R‐ und S‐konfigurierter Piperidinalkohole 9, des Piperidinketons 13, der (R)‐Homopipecolinsäure 12R und des Alkaloids (+)‐Sedamin 10RR eingesetzt werden.
Zur chemischen Stabilität des Fenetyllins
Authors: Rücker Gerhard , Neugebauer Martina , Neugebauer Michael , Heiden Paul‐G. 
Published: July 2014

AbstractBei der Untersuchung der chemischen Stabilität des Phenylethylaminderivates Fenetyllin (1) wurden unter den angewandten Reaktionsbedingungen (100 °C; pH 12–14) Spaltungsreaktionen im Xanthin‐Teil des Moleküls, wie sie bei Coffein bekannt sind2, 3), beobachtet. Es trat keine Abspaltung des Amphetamin‐Restes ein.
Enantio‐separation of drugs with multiple chiral centers by chromatography and capillary electrophoresis
Authors: Al‐Othman Zeid A. , Al‐Warthan Abdulrahman , Alam Syed Dilshad , Ali Imran 
Published: July 2014

ABSTRACTSome drugs with more than one chiral center are of high medicinal values. However, the chiral resolution of such types of racemate is a challenging task for scientists. The evolution of efficient chiral selectors is a hope for the future. Some papers have described such types of chiral resolution. The different techniques used for the purpose are HPLC, micellar electrokinetic chromatography, supercritical fluid chromatography, capillary electrochromatography and capillary electrophoresis. Owing to these facts, it was necessary to review the enantiomeric resolution of racemic drugs having more than one chiral center. The present article describes the chiral resolution of labetalol, formoterol, nadolol, indenolol, nebivolol and diltiazem using above cited techniques. In addition, attempts have been made to discuss the chiral recognition mechanism and future perspectives. Copyright © 2014 John Wiley & Sons, Ltd.
ChemInform Abstract: Synthesis, Structures, and Magnetic Properties of Rare‐Earth Cobalt Arsenides, RCo2As2 (R: La, Ce, Pr, Nd).
Authors: Shatruk Michael , et al. et al. 
Published: July 2014

AbstractLnCo2As2 (Ln: La, Ce, Pr, Nd) are obtained by reaction of stoichiometric amounts of the elements in a Bi flux, which also allows the growth of single crystals (evacuated silica tubes, 1173 K, 10 d).
ChemInform Abstract: Facile Lithium Ion Transport Through Superionic Pathways Formed on the Surface of Li3V2(PO4)3/C for High Power Li Ion Battery.
Authors: Han Dong‐Wook , Lim Sung‐Jin , Kim Yong‐Il , Kang Seung Ho , Lee Yoon Cheol , Kang Yong‐Mook 
Published: July 2014

AbstractC‐supported Li3V2‐xZrx(PO4)3 (x = 0, 0.05, 0.1) is prepared by mixing stoichiometric amounts of Li2CO3, V2O5, Zr(OH)4, and NH4H2PO4 in H2O/EtOH containing 3% sucrose followed by calcination of the dried precursor (5 wt% H2/N2, 750 °C, 10 h).
ChemInform Abstract: The Bismuth Hydrogen Sulfate [Bi2(SO4)2(dmso)8] (HSO4)2.
Authors: Wrobel Lydia , Miersch Linda , Schlesinger Maik , Rueffer Tobias , Lang Heinrich , Mehring Michael 
Published: July 2014

Abstract[Bi2(SO4)2(dmso)8] (HSO4)2 is prepared by the reaction of basic [Bi6O4(OH)4(NO3)6] ·H2O with either thiosalicylic acid or H2SO4 in DMSO (80 °C, 7 h, slow diffusion of Me2CO into the solution).
ChemInform Abstract: Synthesis, Crystal Structure, and Magnetic Properties of Novel Intermetallic Compounds R2Co2SiC (R: Pr, Nd).
Authors: Zhou Sixuan , Mishra Trinath , Wang Man , Shatruk Michael , Cao Huibo , Latturner Susan E. 
Published: July 2014

AbstractThe title compounds are prepared by reaction of silicon and carbon in either a Pr/Co or a Nd/Co eutectic flux (alumina crucible, 950 °C, 12 h and 850 °C for 48 h).
ChemInform Abstract: Enantioselective Formal α‐Allylation of Nitroalkanes Through a Chiral Iminophosphorane‐Catalyzed Michael Reaction—Julia—Kocienski Olefination Sequence.
Authors: Uraguchi Daisuke , Nakamura Shinji , Sasaki Hitoshi , Konakade Yuki , Ooi Takashi 
Published: July 2014

AbstractP‐chiral phosphoranes are employed as catalyst in the highly anti‐diastereoselective and enantioselective Michael reaction of vinyl sulfonates with nitroalkenes under kinetic conditions.
ChemInform Abstract: Isothiourea‐Mediated Asymmetric Functionalization of 3‐Alkenoic Acids.
Authors: Morrill Louis C. , Smith Samuel M. , Slawin Alexandra M. Z. , Smith Andrew D. 
Published: July 2014

AbstractIn the presence of the isothiourea (ITU), 3‐alkenoic acids are found to react with enones, diazenes, and aldimines giving [4 + 2] or [2 + 2] cycloadducts through α‐functionalization.
ChemInform Abstract: Visible Light Photoredox‐Catalysed Intermolecular Radical Addition of α‐Halo Amides to Olefins.
Authors: Nakajima Masaki , Lefebvre Quentin , Rueping Magnus 
Published: July 2014

Abstractα‐Chloro amides are shown to be a new class of α‐acetyl radical precursors, which undergo photoredox‐catalyzed intermolecular α‐addition with various olefins exclusively in an anti‐Markovnikov fashion.
ChemInform Abstract: Sodium Hypochlorite Pentahydrate (NaOCl·5H2O) Crystals as an Extraordinary Oxidant for Primary and Secondary Alcohols.
Authors: Okada Tomohide , Asawa Tomotake , Sugiyama Yukihiro , Kirihara Masayuki , Iwai Toshiaki , Kimura Yoshikazu 
Published: July 2014

AbstractSodium hypochlorite pentahydrate containing less free sodium hydroxide and sodium chloride oxidizes primary and secondary alcohols to the corresponding aldehydes and ketones in the presence of TEMPO and Bu4NHSO4.
ChemInform Abstract: Chemoselective Ruthenium‐Catalyzed Reduction of Carboxylic Acids.
Authors: Fernandez‐Salas Jose A. , Manzini Simone , Nolan Steven P. 
Published: July 2014

AbstractA general and efficient protocol for the selective reduction of carboxylic acids to alcohols using phenylsilane and a Ru‐complex catalyst is presented.
ChemInform Abstract: Diaryl and Heteroaryl Sulfides: Synthesis via Sulfenyl Chlorides and Evaluation as Selective anti‐Breast‐Cancer Agents.
Authors: Yonova Ivelina M. , Osborne Charlotte A. , Morrissette Naomi S. , Jarvo Elizabeth R. 
Published: July 2014

AbstractThe presented mild one‐pot method shows a broad functional group tolerance.
ChemInform Abstract: Stereospecific Nickel‐Catalyzed Cross‐Coupling Reactions of Alkyl Grignard Reagents and Identification of Selective anti‐Breast‐Cancer Agents.
Authors: Yonova Ivelina M. , Johnson A. George , Osborne Charlotte A. , Moore Curtis E. , Morrissette Naomi S. , Jarvo Elizabeth R. 
Published: July 2014

AbstractA highly stereospecific Ni‐catalyzed Kumada cross‐coupling is presented.
ChemInform Abstract: Assessing the Utility of HAlCl2 Derived Vinylalanes for Michael Addition.
Authors: Willcox Darren , Gondal Humaira , Civit Marc Garcia , Woodward Simon 
Published: July 2014

AbstractTi‐ or Zr‐promoted reactions of terminal alkynes with HAlCl2 generate alkenylalanes which can be trapped with alkylidenemalonates to give 1,4‐addition products (III) and (VI) in a simple one‐pot manner.
ChemInform Abstract: Halocarbocyclization versus Dihalogenation: Substituent Directed Iodine(III) Catalyzed Halogenations.
Authors: Stodulski Maciej , Goetzinger Alissa , Kohlhepp Stefanie V. , Gulder Tanja 
Published: July 2014

AbstractThe introduced catalyst enables chemoselective dibromination of alkenes and alkynes and dichlorination of alkenes with high anti‐selectivity.
ChemInform Abstract: Organocatalytic Domino Reaction of Electron‐Deficient 2,4‐Dienes with 2‐Halo‐1,3‐dicarbonyl Compounds: A Highly Regio‐ and Stereoselective Approach to Functionalized Five‐Membered Carbocycles.
Authors: Xie Jian‐Wu , Xu Mei‐Lan , Zhang Ren‐Zun , Pan Jin‐Yun , Zhu Wei‐Dong 
Published: July 2014

AbstractA novel domino Michael reaction/alkylation/vinylcyclopropane rearrangement of electron‐deficient 2,4‐dienes with 2‐halo‐1,3‐dicarbonyl compounds is developed to allow the synthesis of highly functionalized cyclopentane derivatives.
ChemInform Abstract: Synthesis of Bis(heteroaryl) Ketones by Removal of Benzylic CHR and CO Groups.
Authors: Maji Arun , Rana Sujoy , Akanksha Akanksha , Maiti Debabrata 
Published: July 2014

AbstractThis synthesis of bisaryl ketones by removal of benzylic ‐CH2‐, ‐CO‐, and ‐CHR‐ groups uses air as the oxidant in the presence of a copper catalyst and toluidine as acceptor of the removed carbon.
ChemInform Abstract: Ruthenium(IV) Porphyrin Catalyzed Highly Selective Oxidation of Internal Alkenes into Ketones with Cl2pyNO as Terminal Oxidant.
Authors: Wang Zhi‐Ming , Sang Xue‐Ling , Che Chi‐Ming , Chen Jian 
Published: July 2014

AbstractA mild method to convert internal alkenes into ketones by oxidation with 2,6‐dichloropyridine N‐oxide with a Ru‐porphyrin catalyst without any C=C double bond cleavage.
ChemInform Abstract: Rhodium‐Catalyzed Intermolecular Reaction of Alkyl Azides with Diazo(aryl)acetates.
Authors: Gu Peiming , Wu Xiu‐Ping , Su Yan , Li Xue‐Qiang , Xue Ping , Li Rui 
Published: July 2014

AbstractThe initial products of this reaction are α‐imino esters, formed with release of two molecules of nitrogen.
ChemInform Abstract: Synthesis of N,N‐Diethylbenzamides via a Nonclassical Mitsunobu Reaction.
Authors: Hoffman J. Mason , Miller Justin N. , Gardner Margaret E. , LePar Danielle R. , Pongdee Rongson 
Published: July 2014

AbstractThe first application of the Mitsunobu reaction for the construction of benzamides from various benzoic acids and amine is presented.
ChemInform Abstract: Synthesis of Chiral α‐Diarylacetic Esters by Stereospecific 1,2‐Aryl Migration Promoted by in situ Generated Acetals from Benzoins.
Authors: Kothapalli Raveendra Babu , Niddana Ramana , Balamurugan Rengarajan 
Published: July 2014

AbstractTransformation of 1‐hydroxy‐1‐phenylpentan‐2‐one and 1‐hydroxy‐3‐methyl‐1‐phenylbutan‐1‐one results in complex reaction mixtures.Chiral substrates (IV) react with the inversion of the stereocenter.
ChemInform Abstract: Synthesis and Characterization of Polybrominated Fluorenes and Their Conversion to Polyphenylated Fluorenes and Cyclopenta[def]triphenylene.
Authors: Kumar Sushil , Karthik Durai , Thomas K. R. Justin , Hundal Maninder Singh 
Published: July 2014

AbstractSeveral polybrominated fluorene derivatives [including (I) and (IV)] are prepared from 9,9‐diethyl‐9H‐fluorene via stepwise bromination with bromine.
ChemInform Abstract: Synthesis of Spiro[chroman/tetrahydrothiophene‐3,3′‐oxindole] Scaffolds via Heteroatom‐Michael—Michael Reactions: Easily Controlled Enantioselectivity via Bifunctional Catalysts.
Authors: Huang Youming , Zheng Changwu , Chai Zhuo , Zhao Gang 
Published: July 2014

AbstractStereodefined spirooxindoles are prepared via thiourea‐catalyzed Michael‐Michael‐reaction.
ChemInform Abstract: A Regio‐ and Stereoselective ω‐Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5‐Disubstituted Pyrrolidines.
Authors: O'Reilly Elaine , Iglesias Cesar , Ghislieri Diego , Hopwood Jennifer , Galman James L. , Lloyd Richard C. , Turner Nicholas J. 
Published: July 2014

AbstractThe chemoselective reductive cyclization of diones of type (I) in the presence of transaminase ATA113 is presented.
ChemInform Abstract: Silver‐Catalyzed One‐Pot Cyclization/Fluorination of 2‐Alkynylanilines: Highly Efficient Synthesis of Structurally Diverse Fluorinated Indole Derivatives.
Authors: Yang Lei , Ma Yuanhong , Song Feijie , You Jingsong 
Published: July 2014

AbstractTransformation of alkyl or TMS‐substituted alkinylanilines leads to decomposition of the starting materials.
ChemInform Abstract: Organocatalytic Enantioselective Tandem Michael Addition‐Oxidation of 3‐Substituted Oxindoles with 1,4‐Benzoquinone.
Authors: Zhang Yonghong , Hu Xiaoyan , Li Shuaishuai , Liao Yijun , Yuan Weicheng , Zhang Xiaomei 
Published: July 2014

AbstractThis efficient title reaction affords the corresponding 3,3 disubstituted oxindole derivatives in moderate to good yields and with up to 96% enantiomeric excess.
ChemInform Abstract: Structural Design, Synthesis and Structure—Activity Relationships of Thiazolidinones with Enhanced anti‐Trypanosoma cruzi Activity.
Authors: Moreira Diogo Rodrigo Magalhaes , et al. et al. 
Published: July 2014

AbstractCompounds (IIIb) and (IIIc) show the highest antiparasitic activity out of a series of 17 new title compounds.
ChemInform Abstract: Mn(III)‐Based Reaction of Alkenes with Quinolinones. Formation of Peroxyquinolinones and Quinoline‐Related Derivatives.
Authors: Nishino Hiroshi , Kumabe Ryoukou , Hamada Ryoichi , Yakut Mehtap 
Published: July 2014

AbstractThe Mn(III)‐promoted aerobic oxidation of alkenes in the presence of 4‐hydroxyquinolin‐2(1H)‐ones under different reaction conditions is examined resulting in the formation of various types of quinoline derivatives.
ChemInform Abstract: Synthesis and Evaluation of 2‐(1H‐Indol‐3‐yl)‐4‐phenylquinolines as Inhibitors of Cholesterol Esterase.
Authors: Muscia Gisela C. , Hautmann Stephanie , Buldain Graciela Y. , Asis Silvia E. , Guetschow Michael 
Published: July 2014

AbstractA series of new 2‐substituted quinoline derivatives is synthesized via a microwave‐assisted, acid‐catalyzed reaction of o‐aminobenzophenones with acetophenones (II).