bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Carotid Intima-Media Thickness (CIMT) and Alzheimers Disease Detected by 99mTc- ECD SPECT of Brain
Authors: Anar Ashrafi , Adnan Sheikh Md , Sultana Nasreen 
Published: June 2024

Background: Single-photon emission computed tomography (SPECT) imaging of brain has emerged as a well-established and non-invasive technique for diagnosing dementia, specifically its primary subtype, Alzheimer’s disease (AD). Recent research suggested a potential correlation between the increased intima-media thickness of the carotid artery and the onset of AD. The primary objective of this study is to assess the association between carotid intima-media thickness (CIMT) measured by 2D ultrasound of the carotid artery and AD, detected by Brain SPECT imaging with 99m Technetium-Ethyl Cysteinate Dimer (99m Tc ECD). Patients and Methods: This cross-sectional study was conducted at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS) between March 2021 to June 2022. Ethical approval was obtained from Medical Research Ethics Committee (MREC). The study included 65 patients with suspected or confirmed dementia. Data collection included Mini Mental State Examination (MMSE) score of neurology and associated laboratory reports. All the participants underwent 2D ultrasonography of carotid artery to measure carotid intima-media thickness (CIMT) and a brain SPECT with 99mTc-ECD followed by image interpretations using the easy Z score imaging system (eZIS). Result: The mean age of the study population was 63.8 ± 9.5 years, with a male predominance (69.2%). The most prevalent comorbidities were hypertension and dyslipidemia (24.6%) and diabetes mellitus (13.8%). The majority of patients scored in the 25.27 range on the MMSE. Regarding CIMT, 40% of patients had moderate CIMT, 35.4% had normal CIMT, and 24.6% had mildly increased CIMT. Brain SPECT results indicated that 69.2% of patients had Alzheimer’s disease (AD), while 30.8% had dementia other than AD. Among AD patients, 71.1% had mild AD, 20.0% had moderate AD, and 8.9% had severe AD. An unpaired t-test revealed a slightly higher mean CIMT value in AD patients (1.28±0.58 mm vs. 1.25 ± 0.60 mm, p = 0.873), though this difference was not statistically significant. Conversely, ANOVA and Pearson’s correlation tests demonstrated a statistically significant association between CIMT and the severity of AD, as represented by the Z-score (r = +0.693, p<0.001). Conclusion: The study highlights the significance of carotid intima-media thickness (CIMT) in Alzheimer’s disease (AD) and non-AD patients, suggesting its use in initial assessment and follow-up measures.
Bangladesh J. Nuclear Med. 27(1): 49-55, 2024
The Intricate Diagnostic Journey of a Breast Cancer Patient, Revealing Extensive Hepatic Metastasis Through Extraosseous Uptake in Planar Bone Scintigraphy and SPECT-CT Precision Mapping
Authors: Akhter Afroza , Sharmin Shaila , Rahman Farhana , Islam Sabrina , Hossain Sadia , Afrin Rawnak , Biswas Tanima , Begum Rubina , Biswas Shankar Kumar , Haque Jasmine Ara , Mahmud Mohammad Ashraf Us Zaman 
Published: June 2024

In breast cancer patients, planar bone scintigraphy is commonly used for detecting osseous metastasis. This case report emphasizes the importance of recognizing unusual extraosseous uptake in bone scintigraphy, even when negative for osteoblastic lesions. A 35-year-old post-treatment breast carcinoma patient exhibited unexpected radiotracer uptake in the upper abdomen. Subsequent SPECT/CT revealed radiotracer-avid calcified hepatic lesions and extensive non-avid metastatic lesions, however no osteoblastic metastasis. Ultrasound-guided core biopsy confirmed extensive hepatic metastases secondary to ductal carcinoma of the breast. This highlights the critical role of SPECT/CT in precisely identifying and characterizing lesions, aiding in advanced breast cancer diagnosis and management planning.
Bangladesh J. Nuclear Med. 27(1): 121-126, 2024
Insatiabilities
Authors: Kulikovska Maria , Laster Dominika , Najdi Rima , Ni Xena , Ruskin Mollie , Smith Ariel , Szucs Aniko 
Published: June 2024

In July 2022, the Performance in Historical Paradigms Working Group brought together five artists whose creative work engages with issues related to food, hunger, and insatiability. Taking up the provocation of the PSi #27 conference theme “Hunger,” we explored the matrices of the material practices, embodied experiences, socio-economic conditions, as well as the psychosomatic and affective modalities of hunger.
The formally diverse works that comprised the online exhibition–and which are now included here–approach these issues from a distinctly feminist perspective: they problematize the fetishization of the deprived female body, the oppressive powers that generate inequities of food distribution, and the heteronormative gender norms that perpetuate women’s responsibilities as nurturers, providers, and caretakers. Further, they examine the ways in which these processes are socially structured and transmitted intergenerationally. The pieces demonstrate how instances of contemporary crises are rooted in enduring historical legacies and entrenched in systemic inequities.
Motorik Halus Anak Usia Dini di TK Negeri GOW Kabupaten Rejang Lebong
Authors: Nurmiati Eliza , Delrefi D  , Qalbi Zahratul 
Published: June 2024

Abstrak

Penelitian ini bertujuan untuk mengetahui kemampuan pengembangan motorik halus anak usia dinidi Taman kanak-kanak Negeri GOW Kabupaten Rejang Lebong. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Subjek Penelitian ini adalah Kepala Sekolah dan Guru Pendidikan Anak Usia Dini Taman kanak Negeri GOW Kabupaten Rejang Lebong. Teknik pengumpulan data menggunakan wawancara, observasi dan catatan lapangan. Analisis data dilakukan dengan langkah sebagai berikut: reduksi data, penyajian data, dan penarikan kesimpulan. Pemeriksaan keabsahan data menggunakan teknik triangulasi. Hasil penelitian ini menunjukan bahwa perencanaan pembelajaran Taman kanak-kanak Negeri GOW terdiri dari menentukan tema dan subtema, menentukan Kompetensi Inti,Kompetensi Dasar, menentukan indikator dan menetapkan tujuan pembelajaran. Pelaksanaan pembelajaran Taman kanak-kanak Negeri GOW dengan penyusunan Rencana Pelaksanaan Pembelajaran Harian dan perumusan tujuan pembelajaran. Penilaian pembelajaran dilakukan dengan beberapa metode yaitu observasi, percakapan, penugasan, unjuk kerja, hasil karya dan pencatatan anekdot.

Kata Kunci: Motorik Halus, Anak Usia Dini

Abstract

This study aims to determine the ability of fine motor development of early childhood in GOW State Kindergarten, Rejang Lebong Regency. This research use desciptive qualitative approach. The subjects of this study were the Principal and Early Childhood Education Teacher of GOW State Kindergarten, Rejang Lebong Regency. Data collection techniques used interviews, observations and field notes. Data analysis was carried out with the following steps: data reduction, data presentation, and drawing conclusions. Checking the validity of the data using triangulation technique. The results of this study indicate that the GOW State Kindergarten learning planning consists of determining themes and subthemes, determining Core Competencies, Basic Competencies, determining indicators and setting learning objectives. Implementation of learning in GOW State Kindergarten with the preparation of Daily Learning Implementation Plans and formulation of learning objectives. Learning assessment is carried out by several methods, namely observation, conversation, assignment, performance, work and recording anecdotes.

Keywords: Fine Motor, Early Childhood
Salvage CD20-SD-CART therapy in aggressive B-cell lymphoma after CD19 CART treatment failure
Authors: Xue Fei , Zheng Peihao , Yang Fan , Liu Rui , Feng Shaomei , Guo Yuelu , Shi Hui , Ma Lixia , Deng Biping , Xu Teng , Zhang Jiecheng , Zhou Qi , Ke Xiaoyan , Hu Kai 
Published: June 2024

Background and aimsPatients with relapsed/refractory aggressive B-cell lymphoma(r/r aBCL)who progressed after CD19-specific chimeric antigen receptor T-cell therapy (CD19CART) had a poor prognosis. Application of CAR T-cells targeting a second different antigen (CD20) expressed on the surface of B-cell lymphoma as subsequent anti-cancer salvage therapy (CD20-SD-CART) is also an option. This study aimed to evaluate the survival outcome of CD20-SD-CART as a salvage therapy for CD19 CART treatment failure.MethodsThis retrospective cohort study enrolled patients with aBCL after the failure of CD19 CART treatment at Beijing Gobroad Boren Hospital from December 2019 to May 2022. Patients were subsequently treated with CD20CART therapy or non-CART therapy (polatuzumab or non-polatuzumab).ResultsA total of 93 patients were included in the study, with 54 patients receiving CD20-SD-CART therapy. After a median follow-up of 18.54 months, the CD20-SD-CART group demonstrated significantly longer median progression-free survival (4.04 months vs. 2.27 months, p=0.0032) and median overall survival (8.15 months vs. 3.02 months, p&lt;0.0001) compared to the non-CART group. The complete response rate in the CD20-SD-CART group (15/54, 27.8%) was also significantly higher than the non-CART group (3/38, 7.9%, p=0.03). Multivariate analysis further confirmed that CD20CART treatment was independently associated with improved overall survival (HR, 0.28; 95% CI, 0.16–0.51; p&lt;0.0001) and progression-free survival (HR, 0.46; 95% CI, 0.27–0.8; p=0.005).ConclusionCD20-SD-CART could serve as an effective therapeutic option for patients with relapsed or refractory aggressive B-cell lymphoma after CD19CART treatment failure.
Tumor budding - a potential biomarker in low grade salivary gland carcinomas?
Authors: Burkhardt Valentin , Kayser Gian , Villing Theo , Becker Christoph 
Published: June 2024

BackgroundLow-grade salivary gland carcinoma is regularly treated with surgical therapy of the salivary gland without elective neck dissection in T1/2 carcinomas, either alone or with adjuvant radiation therapy. However, occult metastasis and locoregional recurrence influence therapy and outcome. Tumor budding is an emerging prognostic pathological factor in many carcinomas, but has not yet been adequately considered in salivary gland carcinomas.MethodsWe conducted a retrospective single-center study of 64 patients diagnosed with low-grade carcinoma of the major salivary glands treated between 2003 and 2017. Pathological risk factors and TNM classification were thoroughly assessed for each case. All hematoxylin and eosin (HE)-stained histological specimens underwent careful examination, and tumor budding was identified following the guidelines set forth by the International Tumor Budding Consensus Conference in 2016.ResultsTumor budding was not statistically significant concerning 5-year survival rate (5-YSR) (p=0.969) and mean overall survival (log-rank p=0.315). Whereas 5-year disease-free survival rate (5-YDFSR) was 87% in the low tumor budding group and 61.1% in the intermediate and high tumor budding group (p=0.021). Mean disease-free survival accounted for 100.2 months (CI: 88.6;111.9) in the low budding score group and 58.7 months (CI: 42.8;74.6) in the other group (log-rank p=0.032). Notably, pT1/2 showed significantly lower tumor buds than pT3/4 stages (2.43 tumor buds/0.785 mm2 vs. 4.19 tumor buds/0.785 mm2, p=0.034). Similar findings were noted comparing nodal-positive and nodal-negative patients, as well as patients with and without lymphovascular invasion and perineural invasion (each p&lt;0.05).ConclusionsTumor budding might be used as an additional prognostic factor for recurrence in low-grade salivary gland carcinoma, seemingly associated with a higher nodal metastasis rate and advanced tumor stages and a worse 5-YDFSR. Consequently, the evaluation of tumor budding in resection specimens of low-grade salivary gland tumor may prove valuable in decision-making for neck dissection and follow-up strategy.
Researching into Chinese university students’ mental health in the post-pandemic era – problems and causes
Authors: Ning Xuan , Luo Xiaoyu , Guo Sijia 
Published: June 2024

IntroductionMental health challenges have still been widely pervasive among Chinese university students after the outbreak of the COVID-19 pandemic. This article aims to explore mental health challenges encountered by Chinese university students in the post-pandemic era and explain causes to these challenges using a qualitative approach.MethodsWe conducted six focus group interviews with university students in Zhuhai, China, and altogether 61 students including 43 female students, and 18 male students participated in the study.ResultsOur results indicate that sleep difficulties, anxiety, and stress are the three primary mental health challenges experienced by students. Academic pressure, social influence including peer pressure and pursuit of social acceptance, and pandemic related policies and measures are the causes to the above mental health challenges.DiscussionThe results of this study will inform the development of mental health promotion, intervention, and education activities for university students to bolster their resilience and cope with mental health problems in the post-pandemic era. Meanwhile, our results could illuminate the services stakeholders provide to university students in the future.
Comparison of Static Stretching and Muscle Energy Techniques on Hamstring Tightness in Asymptomatic Females
Authors: Majeed Ayesha , Mansoor Syeda Rafia , Arif Ahmad Bilal , Yasin Muhammad Mudassar , Wasim Minahil , Naeem Farah 
Published: June 2024

Background: Hamstring flexibility is an essential variable because decreased extensibility can cause injuries, non-specific low back pain and altered lumbopelvic rhythm. Flexibility training is an important component in preventing or rehabilitation of injuries and also a method of improving one’s performance in everyday activities and sports.
Objectives: To compare the effects of static stretching & muscle energy techniques on hamstring shortness in females.
Methods: A randomized controlled trial conducted at Department of Health Sciences, Khawaja Fareed University of Engineering & Information Technology Rahim Yar Khan on 50 asymptomatic females. In this study, 50 females were randomly allocated in two groups strictly following the inclusion/exclusion criteria. Group A received hamstring static stretching, while group B muscle energy techniques (Autogenic inhibition). Informed written consent was taken from each participant. 90-90 test, SLR, Sit and reach test were used as outcome measurement tools of hamstring tightness. 6 sessions in 2 weeks were given to each participant. Baseline as well as follow-up data after 2 consecutive weeks was recorded.
Results: Mean age of participants of Groups A & B were 26±1.2, 26±0.9 years respectively. Group B participants showed marked improvement at 90-90 test, SLR, Sit and reach outcome measurement tools compared to group A as p-value was found less than 0.05 which is considered significant.
Conclusion: Muscle energy techniques particularly autogenic inhibition have better treatment outcome as compared to hamstring static stretching alone in asymptomatic females with hamstring shortness.
Charles-Philippe Larivière, grand prix de Rome de 1824, ou les dangers d'un séjour en Italie
Authors: Loddé Isabelle 
Published: June 2024

Isabelle Loddé, Philippe Larivière, grand prix de Rome di 1824 o i pericoli di un soggiorno in Italia ;
Charles-Philippe Larivière, grand prix di pittura di storia del 1824, è pensionnaire all' Académie de France in Roma tra 1825 e 1830. Questi anni trascorsi in Italia sono conosciuti grazie ad un'abbondante corrispondenza e un corpus di opere il cui studio permette di afferrare le scelte artistiche del pittore : studi realizzati dalla natura, copie dai maestri, envois obbligatori di pensionnaire. La maturazione dello stile di Larivière si avviene al momento in cui la battaglia romantica si combatteva al Salon di Parigi. Esitando tra le sue aspirazioni romantiche e la ragione che lo guidava verso una pittura più convenzionale, egli diventa un pittore del juste-milieu garantendosi così la carriera promessa agli ex-borsisti di Villa Medici.
Le lieu privé du peintre. Autoportraits et ateliers comme configurations du champ de l’art
Authors: Recht Roland 
Published: June 2024

Der Privatraum des Malers. Selbstbildnisse und Ateliers als Konstellationen des Bereiches der Kunst.
Drei entscheidende Momente in der Darstellung des Privatraums des Malers sind zur Analyse herangezogen worden : die Erfindung des Selbstbildnisses und der Atelierdarstellung im 16. Jahrhundert, die bildnerischen Mittel, die die Holländer im 17. Jahrhundert erarbeitet haben, und das Werk Adolph Menzels. Diese drei auf diese Art und Weise vereinten Untersuchungsgebiete erscheinen mir besonders geeignet, um aufzuweisen, daß die verschiedenartige Verwendung des Spiegelbildes, welches auch immer seine Komplexität sein möge und unabhängig von seiner Herkunft von tiefgründigen, den Malern eigenen Interessen, die Rezeption umgewälzt hat, die das Publikum von der Malerei haben konnte, und somit vielleicht vor allem ein Bildaufbau geworden ist, der die Neugier und die Aufmerksamkeit des Betrachters erwecken und verstärken sollte, was zu einer offensichtlichen Erweiterung des Bereiches der Kunst geführt hat.
Tra memoria e conservazione: pale d’altare antiche ricomposte in Piemonte tra età barocca e XIX secolo
Authors: Maria Piavento Orso 
Published: June 2024

Zwischen Erinnerung und Aufbewahrung : im Piemont vom Barock bis zum 19. Jahrhundert umgestaltete alte Altarbilder ;
Diese Studie befasst sich mit der Untersuchung der Umgestaltung des künstlerischen Kulturerbes in ihrem Kontext : es geht insbesondere darum, das Phänomen der Wiederverwendung von Altarbildern aus der Renaissance in Ausstellungsformen aus der Zeit des Barock zu untersuchen, die anlässlich der von der Gegenreformation geforderten Erneuerung des liturgischen Mobiliars konzipiert worden sind. Bei der Studie von Fällen, die alle im Gebiet des Herzogtums und späteren Königreichs von Savoyen situiert sind, kann man das Auftreten der Wiederverwendung verfolgen, sowohl formal als auch die Bedingungen betreffend, die die Aufbewahrung dieser Werke vom 17. und 18. Jahrhundert bis in die heutige Zeit ermöglicht haben. Schlieblich wird die Untersuchung das Verhältnis zwischen der Rezeption eines Künstlers und seinem „materiellen“ Fortwirken, d. h. der Aufbewahrung seiner Werke, im 19. Jahrhundert berücksichtigen, wie dies für Gaudenzio Ferrari gilt, dessen Gemälde im Dom von Novara aufbewahrt werden.
L’Annonciation dans l’espace ecclésial parisien au XVIIIe siècle : liturgie française et modèle italien
Authors: Gouzi Christine 
Published: June 2024

The Annunciation in the Ecclesial Settings of 18th century Paris : French Liturgy and the Italian Model.
In the late 17th century and throughout the 18th century, the Annunciation was one of the most popular subject matters for Parisian altarpieces. Adopted for specific liturgical purposes following the revocation of the Edict of Nantes, it also served as the basis for a new aesthetic in ecclesial decoration. The Annunciation played a key role in 18th-century theological writings as well as in the theoretical debates of the 1750s on the Italian model, and thus occupies an unprecedented place at that period. In order to grasp fully their importance during the Enlightenment, this article sheds new light on representations of the Annunciation, using a renewed iconographical approach grounded in the cultural history of art and the history of religious thought.
Due mostre e il progetto di un museo sul falso. Una storia tra Francia e Italia (1930-1955)
Authors: Prisco Gabriella 
Published: June 2024

Zwei Ausstellungen und einige Überlegungen zur Fälschung. Die Entwicklung in Frankreich und Italien von 1930 bis 1955.
Anhand einer von Cesare Brandi geschriebenen Rezension der Ausstellung, „Le Faux dans l’Art et dans l’Histoire” („Die Fälschung in der Kunst und in der Geschichte”, Paris, 1955) soll der italienische Beitrag zu dieser Ausstellung untersucht werden sowie die Bezüge zwischen Fälschung und künstlerischer Diagnose, die ab den dreißiger Jahren auf verschiedene Weise in Frankreich und Italien aufgefasst worden sind, wovon die damals gegründeten Institute, das Institut Mainini und das Istituto Centrale del Restauro (ICR), zeugen. Andererseits soll die enge Zusammengehörigkeit der Begriffe der Authentizität und der Fälschung untersucht werden, die beide von dem der Anerkennung des Kunstwerks abgeleitet sind und die zwei ständige Ausstellungen des ICR illustriert haben, die zu Beginn der fünfziger Jahre als Gegenstücke konzipiert worden waren. Schließlich soll anhand von Texten, die zur Zeit dieser Ausstellungen geschrieben worden sind, die unterschiedliche Auffassung des Bezugs zwischen Authentizität und ästhetischem Urteil im Denken von Cesare Brandi und Étienne Gilson hervorgehoben werden.
بعض العلاقات بين البعد التأملي - الاندفاعي والتعلم عند طلاب الصف الرابع الابتدائي في الكويت (باللغة الإنجليزية).
Authors: قاسم علي الصراف  
Published: June 2024

هذه الدراسة محاولة للبحث في بعض العلاقات بين البعد التأملي الاندفاعي كأسلوب للتفكير والتحصيل الدراسي عند طلاب الصف الرابع الابتدائي في مدارس الكويت .
ولقد بنيت الدراسة على الفرضيات التالية:
1- يختلف المتفوقون دراسياً عن غير المتفوقين تبعاً لسماتهم التأملية أو الاندفاعية
2- يختلف أداء الأطفال التأمليين عن أداء الأطفال الاندفاعيين بحسب طبيعة الأعمال الحسابية المعهودة إليهم.
3- يكون أداء الأطفال الاندفاعيين أفضل من أداء الأطفال التأمليين في الأشكال الهندسية، بينما يفوق أداء الأطفال التأمليين أداء الأطفال الاندفاعيين في المسائل الحسابية.
وللحصول على العينة التجريبية، طبق على جميع أطفال الصف الرابع الابتدائي في أربع مدارس ابتدائية للبنين اختبار الأشكال المألوفة المنسجمة (MFFT) لكيجان، وبعد استعمال الوسيط الحسابي في حساب عدد الأخطاء وزمن القرار، تم اختيار 64 طالباً (32 تأمليا و 32 اندفاعياً) ليخضعوا للتجربة قيد البحث.
ولإيجاد العلاقة بين الأسلوب المعرفي والتحصيل الدراسي قمنا بالمهمات التالية:
1-	مراجعة الملف الدراسي لكل طفل على حدة للحصول على تقديراته خلال الأربع سنوات من دراسته في المرحلة الابتدائية.
2-	تطبيق اختبار للأشكال الهندسية وآخر للمسائل الحسابية على أفراد العينة.
3-	تطبيق اختبار للأشكال المألوفة المنسجمة ذات تفاصيل عامة وآخر لأشكال دقيقة لإيجاد علاقة بين الإيقاع المعرفي وبعض العمليات الإدراكية عند أفراد العينة.
وبعد معاينة الوقائع إحصائيا باستعمال طريقة تحليل التغاير مع إعادة الإجراء، توصل البحث إلى النتائج التالية:
1-	أنفق الأطفال التأمليون أكثر وقتهم في حل مشكلات اختبار الأشكال المألوفة المنسجمة ذات التفاصيل العامة، وأقل وقتهم في حل المسائل الحسابية.
2-	أكثر أخطاء الأطفال الاندفاعيين كانت في حل مشكلات اختبار الأشكال المألوفة المنسجمة ذات التفاصيل العامة، وأقلها كانت في حل اختبار الأشكال الهندسية.
3-	عند مقارنة المجموعتين، اتضح أن الفرق في عدد الأخطاء بين التأمليين والاندفاعيين ازداد عن الفرق في زمن الاستجابة.
4-	هناك فروق ذات دلالة احصائية بين المجموعتين في التحصيل الدراسي لمادتي القراءة والحساب خلال الأربع سنوات من الدراسة في المرحلة الابتدائية.
5-	أخطاء التأمليين كانت أقل من أخطاء الاندفاعيين في جميع اختبارات الأشكال المألوفة المنسجمة، ولكنهم أنفقوا في حل اختبار الأشكال المألوفة المنسجمة ذات التفاصيل العامة وقتا أكثر من الوقت الذي أنفقوه في حل اختبار الأشكال المألوفة المنسجمة ذات التفاصيل الدقيقة.
6-	عند مقارنة المجموعتين فيما يخص العوامل العامة والعوامل الخاصة للاختبارات، تبين أن التأمليين يتفوقون على الاندفاعيين في جميع هذه العوامل.
7-	كلتا المجموعتين أنفقتا في حل اختبار الأشكال الهندسية وقتا أكثر من الوقت الذي أنفقتاه في حل اختبار المسائل الحسابية، وكذلك ارتكبتا أخطاء أكثر في حل اختبار المسائل الحسابية منها في اختبار الأشكال الهندسية.
ويمكن الاستفادة من نتائج هذه الدراسة ومضامينها في إثراء الممارسات التربوية في مدارس الكويت، بعد أن تبين أن هذه الممارسات لا تأخذ بعين الاعتبار الفروق الفردية المتمثلة في اختلاف الأساليب المعرفية عند الصغار.