bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the nutritional quality of diets of Canadian children and adolescents using the 2014 Health Canada Surveillance Tool Tier System
Authors: Jessri Mahsa , Nishi Stephanie , R. L’Abbé Mary 
Published: August 2024

<p> </p>
<p><strong>Background</strong></p>
<p>Health Canada’s Surveillance Tool (HCST) Tier System was developed in 2014 with the aim of assessing the adherence of dietary intakes with Eating Well with Canada’s Food Guide (EWCFG). HCST uses a Tier system to categorize all foods into one of four Tiers based on thresholds for total fat, saturated fat, sodium, and sugar, with Tier 4 reflecting the unhealthiest and Tier 1 the healthiest foods. This study presents the first application of the HCST to examine (i) the dietary patterns of Canadian children, and (ii) the applicability and relevance of HCST as a measure of diet quality.</p>
<p><strong>Methods</strong></p>
<p>Data were from the nationally-representative, cross-sectional Canadian Community Health Survey 2.2. A total of 13,749 participants aged 2–18 years who had complete lifestyle and 24-hour dietary recall data were examined.</p>
<p><strong>Results</strong></p>
<p>Dietary patterns of Canadian children and adolescents demonstrated a high prevalence of Tier 4 foods within the sub-groups of processed meats and potatoes. On average, 23–31 % of daily calories were derived from “other” foods and beverages not recommended in EWCFG. However, the majority of food choices fell within the Tier 2 and 3 classifications due to lenient criteria used by the HCST for classifying foods. Adherence to the recommendations presented in the HCST was associated with closer compliance to meeting nutrient Dietary Reference Intake recommendations, however it did not relate to reduced obesity as assessed by body mass index (p > 0.05).</p>
<p><strong>Conclusions</strong></p>
<p>EWCFG recommendations are currently not being met by most children and adolescents. Future nutrient profiling systems need to incorporate both positive and negative nutrients and an overall score. In addition, a wider range of nutrient thresholds should be considered for HCST to better capture product differences, prevent categorization of most foods as Tiers 2–3 and provide incentives for product reformulation. </p>
Pengaruh Pelatihan Kerja dan Pengembangan Karir Terhadap Kinerja Pegawai Negeri Sipil (PNS) Dinas Pariwisata Kebudayaan dan Kepemudaan Olahraga Provinsi Kepulauan Bangka Belitung
Authors: Mahdavikia Alif , Agung Nugroho Ari , Prihardini Wibawa Dian 
Published: August 2024

Alif Mahdavikia. 302 19 11 033. Pengaruh Pelatihan Kerja dan Pengembangan Karir terhadap Kinerja Pegawai Negeri Sipil pada Dinas Pariwisata Kebudayaan dan Kepemudaan Olahraga Provinsi Kepulauan Bangka Belitung.

Penelitian ini dilatarbelakangi oleh kinerja pegawai yang menjadi permasalahan yang selalu dihadapi instansi pemerintah, oleh karena itu manajemen perlu mengetahui faktor-faktor yang mempengaruhi kinerja pegawai tersebut. Penelitian ini bertujuan untuk mengetahui dan menganalisis kajian tentang Pengaruh Pelatihan Kerja dan Pengembangan Karir terhadap Kinerja Pegawai Negeri Sipil pada Dinas Pariwisata Kebudayaan dan Kepemudaan Olahraga Provinsi Kepulauan Bangka Belitung. Penelitian ini termasuk penelitian deskriptif. Metode yang digunakan yaitu penelitian kuantitatif. Jumlah sampel dalam penelitian ini adalah 65 responden dengan menggunakan teknik sampel jenuh. Model analisis yang digunakan adalah analisis linier berganda.
Hasil penelitian menunjukkan bahwa variabel pelatihan kerja tidak berpengaruh terhadap kinerja pegawai dan variabel pengembangan karir berpengaruh signifikan terhadap kinerja pegawai. Secara simultan pelatihan kerja dan pengembangan karir berpengaruh kinerja Pegawai Negeri Sipil pada Dinas Pariwisata Kebudayaan dan Kepemudaan Olahraga Provinsi Kepulauan Bangka Belitung.

Kata Kunci: Kinerja, Pelatihan Kerja dan Pengembangan Karir
Monitoring Pediculosis Capitis in Students At Al-Muhajirin Islamic Boarding School, Cikarang Pusat, West Java, Indonesia
Authors: Anindita Reza , Wahyu Ega Nuraini , Perwitasari Melania , Nathalia Dede Dwi , Beandrade Maya Uzia , Harahap Nofria Rizki Amalia 
Published: August 2024

Introduction : Pediculosis capitis is a scalp hair disorder caused by an infestation of the lice of Pediculus humanus capitis. The spread of this disease is dominant in Islamic boarding school students. This disease besides causing itching and lesions on the scalp also causes loss of concentration and enjoyment of learning in children. The objective of this study was to determine the percentage of female students infested with P. humanus capitis.
Methods : The design of this research is cross-sectional. The sample for this study was 41 female students of grade 7 at AL-Muhajirin Islamic Boarding School, Central Cikarang, West Java. Examination of P. humanus capitis on all female students was carried out using the serit method. The P. humanus capitis lice found were then collected and preserved preparations were made for microscopic morphological identification.
Results : The results of this study showed that from 41 samples, 36 (87.8%) students were found to be positive for P. humanus capitis.
Conclusions : The conclusion from this study is that the percentage of pediculosis capitis in female students is high, so it is necessary to take countermeasures in the form of head lice medication and education about personal hygiene for class 7 female students at Al-Muhajirin Islamic Boarding School, Central Cikarang, West Java
Effect of Oral Administration of Mytragina Speciosa on Blood Ketone Level and Glomerular Histology in Streptozotocin Induced Diabetic Mice
Authors: Choirotussanijjah Choirotussanijjah , Salim Hotimah Masdan , Bintarti Tri Wahyuni , Irawan Danny 
Published: August 2024

Introduction: Diabetes mellitus is a chronic metabolic disease characterized by increased sugar levels that cause serious damage to various organs. Diabetic ketoacidosis is one of the complications of diabetes mellitus. It is characterized by a decrease in the patient's consciousness, increased blood sugar levels, and the presence of acidic ketone bodies. It is a serious condition that can cause a coma or even death. Mytragina Speciosa, known as kratom, is a plant often found in Southeast Asia, including Indonesia. This herb is frequently used as a stimulant to treat fatigue and help improve productivity. Based on previous research, Mytragina Speciosa is rich in alkaloids, flavonoids, and phenols. These compounds are very useful for inhibiting the activity of α-glucosidase and lipase enzymes in the pancreas, so they have a potential effect on diabetes mellitus. However, there has been no research related to the administration of Mytragina Speciosa its effect on blood ketone levels and glomerular diameter.
Objective: to determine whether there is an effect of Mytragina Speciosa on blood ketone levels and glomerular diameter in mice with a diabetes mellitus model.
Methods: Hyperglycemia is induced by Streptozotocin. On the 14th day, the mice will be checked for hyperglycemia and blood ketone levels. Administration of Mytragina Speciosa begins on day 15 for 2 weeks. At the end of the second week, the mice will be checked for blood ketone levels using a special kit to detect ketone bodies. Furthermore, the glomerular diameter will also be assessed.
Results: In this study, treatment for 2 weeks only caused an increase in blood sugar levels in mice, but did not cause an increase in blood ketone levels in the diabetes group or other treatment groups (p > 0.05). Histological preparation of the Glomerulus showed a decline in glomerular diameter.
Conclusions: The administration of Mitragyna speciosa extract did not result in a significant increase in blood ketone levels in diabetic mice. Many factors are involved in increasing blood ketone. It is necessary to monitor ketone levels during treatment as well as have a longer treatment time to see the effect of Mitragyna speciosa on ketones
Impact of Storage on Alteration in Biochemical and Hematological Characteristics in Locally Donated Blood from Lampung Province: Assessing Potential Risks for Recipients
Authors: Yuniza Filia , Nur Khoiriyah Yustin , Danan Jaya Bayu Putra 
Published: August 2024

The utilization of stored blood for transfusion purposes is a common practice in Blood Transfusion Units worldwide. However, the storage period can induce various cellular alterations, potentially comprising the quality and efficacy of blood transfusions. This study aims to investigate changes in biochemical and hematological parameters in blood donors during the storage period. This study was a prospective study involving the observation of 10 blood bags collected from local community donors in Lampung Province. The blood samples were stored in CPDA-1 anticoagulant bags at a controlled temperature of 2-6 ° C for 35 days. At regular intervals of 7 days, comprehensive assessments were performed, encompassing complete blood parameters, electrolyte concentration (Na+, K+, Cl-), and blood pH levels. After 35 days of storage, statistically significant alterations were observed. Notably, there was a significant increase in hematocrit levels (p=0.000), mean corpuscular volume (MCV) (p=0.019), lymphocyte counts (p=0.000), and potassium concentrations (p=0.000). Conversely, mean corpuscular hemoglobin concentration (MCHC) (p=0.025), leukocyte counts (p=0.000), neutrophil counts (p=0.000), platelet counts (p=0.000), sodium levels (p=0.000), chloride levels (p=0.000), and pH values (p=0.000) were significantly declines. In conclusion, blood storage leads to notable alterations in biochemical and blood cell characteristics. Therefore, it is advisable to prioritize using fresh whole blood or blood stored for no more than seven days in transfusion practices to minimize the risk of post-transfusion reactions, especially in vulnerable recipients.
Keywords: Blood transfusion, biochemical changes, cellular changes, storage.
تاثير تمرينات للدفاع الضاغط المتقدم (Advanced Press) باسلوب التدريب المكثف في بعض القدرات البدنية الخاصة و المهارات لدى اللاعبين الناشئين بكرة القدم
Authors: Dr. Ali Nazem Kwir  
Published: August 2024

تضمن البحث اربع أبواب احتوى الباب الأول على مقدمة البحث وأهميته وتم التطرق الى اهمية الدفاع الضاغط المتقدم وفعاليته في إجبار الخصم على ارتكاب الأخطاء واستغلال هذه الأخطاء لتحقيق أهداف سريعة. هو استراتيجية دفاعية استباقية يتم فيها تطبيق الضغط الفوري على اللاعب الخصم. يمكن أن يؤدي إتقان هذه التمرينات بالاسلوب المكثف إلى تحسين كبير في قدرات اللاعبين المهاجمين الدفاعية وأدائهم العام في اللعبة. اما مشكلة البحث تتلخص بان هناك تفاوت بين اللاعبين المهاجمين ولاعبي الوسط الناشئين في اداء الواجبات الخططية الدفاعية فمنهم يملك القدرة الضعيفة ومنهم المتوسطة و منهم العالية على تنفيذ الواجبات الخططية بشكل صحيح خلال مواقف اللعب المختلفة اســتخدام المنهج التجريبي بتصميم المجــمـوعتين التجريبية والمجموعة الضابطة على عينة من لاعــــــــبي المدارس التخصصية للموهبة الرياضية واختيار عينة عشوائية تم تقسيمهم عن طريق القرعة الى مجموعتين واجرى الاختبارات القبلية وقام بتطبيق التمرينات وبعدها اجرى الاختبارات البعدية.واستنتج الباحث إن تمرينات الدفاع الضاغط المتقدم (Advanced Press) باسلوب التدريب المكثف تعمل على تطوير القدرات البدنية الخاصة و المهارات لدى اللاعبين الناشئين واوصى المدربين باستخدام هذه النوعية من التمارين
PERAN DINAS PERHUBUNGAN DALAM PENGELOLAAN PERPARKIRAN GUNA MENINGKATKAN RETRIBUSI PARKIR DI KABUPATEN GRESIK
Authors: Akbar Rozy , Hardjati Susi 
Published: August 2024

In running a regional government, of course, costs or budgets are needed so that the government functions can run. Parking fees have a potential opportunity to become a contributor to regional revenue as well as APBD if it can be managed properly. Some people think that parking fees are the same as parking taxes. The purpose of this study was to determine the role of the transportation agency in parking management in order to increase parking fees in Gresik Regency. This research method is descriptive qualitative. Data collection was obtained from interviews, observation, literature review and documentation. The results of the study show that the Department of Transportation in managing parking has an important role in increasing parking fees in Gresik Regency. With the efforts made by the Gresik Regency transportation service with all its policies, regional income in the Gresik Regency parking retribution sector has increased.Dalam menjalankan suatu pemerintah daerah tentu diperlukan biaya atau anggaran agar fungsi pemerintahan tersebut dapat berjalan. Retribusi parkir memiliki peluang yang cukup potensial untuk menjadi penyumbang dalam penerimaan Pendapatan Asli Daerah sekaligus APBD apabila dapat dikelola dengan baik. Sebagian masyarakat mengira bahwa retribusi parkir sama dengan pajak parkir. Tujuan penelitian ini adalah untuk mengetahui peran dinas perhubungan dalam pengelolaan perparkiran guna meningkatkan retribusi parkir di Kabupaten Gresik. Metode penelitian ini adalah deskriptif kualitatif. Pengumpulan data diperoleh dari wawancara, observasi, kajian literatur dan dokumentasi. Hasil penelitian menunjukkan bahwa dinas perhubungan dalam mengelola perparkiran memiliki peranan penting guna meningkatkan retribusi parkir di Kabupaten Gresik. Dengan upaya – upaya yang dilakukan oleh dinas perhubungan Kabupaten Gresik dengan segala kebijakannya menjadikan pendapatan daerah di sektor retribusi parkir Kabupaten Gresik meningkat.
ANALISIS PERAN BANK SAMPAH HAPAKAT HATANTIRING DESA LUWUK KANAN SEBAGAI BENTUK PARTISIPASI MASYARAKAT DALAM PENGELOLAAN
Authors: Imut Dea , Riyanti Nova 
Published: August 2024

Waste banks are waste handling places available in Indonesia to help deal with common problems that occur due to waste. In this activity, the more people from Luwuk Kanan village participate, the more waste management at the Hapakat Hatantiring waste bank can develop. The aim of this research is to analyzethe role of the Hapakat Hatantiring waste bank in Luwuk Kanan village as a form of community participation in waste management. This research uses descriptive qualitative research methods. Data collection through Observation,Iinterviews, Documentation. From the research results, it is known that commonity participation is still lacking, this can be seen from the fact that only a few people who are classified as elderly and school children partisipate in managing waste at the Hapakat Hatantiring waste bank Luwuk Kanan village. This is due to a lack of education from the waste bank to the community about the importanceof participating in waste management. The Hapakat Hatanting waste bank can collect approximately 20-30 Kg of waste in 1 week. However this activity is still not optimal because it is limited by implementation time which is only carriedout once a week. The Hapakat Hatantiring waste bank’s suggestion is to increase its operational hours two to three times a week so that the role of the waste bank can be more optimal and the waste bank management can educate the public about the importance of participating in waste bank management. Bank sampah adalah tempat penanganan sampah yang tersedia di indonesia dalam membantu menangani permasalahan umum yang terjadi akibat sampah. Dalam kegiatan ini semakin banyak masyarakat desa Luwuk Kanan ikut berpartisipasi maka dapat semakin berkembang pula pengelolaan sampah pada bank sampah Hapakat Hatantiring. Tujuan penelitian ini adalah untuk menganalisis peran dari bank sampah Hapakat Hatantiring desa Luwuk Kanan sebagai bentuk partisipasi masyarakat dalam pengelolaan sampah. Penelitian ini menggunakan metode kualitatif deskriptif. Pengumpulan data melalui observasi, wawancara dan Dokumentasi. Dari hasil penelitian diketahui partisipasi dari masyarakat masih kurang hal ini dilihat dari hanya beberapa orang yang tergolong lansia dan anak-anak sekolah saja yang ikut berpartisipasi dalam mengelola sampah pada bank sampah Hapakat Hatantiring desa Luwuk Kanan. Hal ini karena kurang nya edukasi dari pihak bank sampah pada masyarakat akan penting nya ikut serta berpartisipasi dalam pengelolaan sampah. Bank sampah Hapakat Hatantiring dapat mengumpulkan kurang lebih sekitar 25-30 Kg sampah dalam 1 minggu. Namun kegiatan ini masih belum optimal karena terkendala waktu pelaksanaan yang hanya dilakukan sekali seminggu. Saran Bank sampah Hapakat Hatantiring menambah waktu operasional 2 sampai 3 kali dalam seminggu agar peran dari bank sampah dapat lebih optimal dan pihak pengelola bank sampah dapat melakukan edukasi pada masyarakat tentang pentingnya ikut berpartisipasi dalam pengeloaan bank sampah.
Struktur komunitas makroinvertebrata bentos di hutan Selorejo Dau Malang
Authors: Noviza Evi Noris , Zayadi Hasan , Prasetya Hamdani Dwi 
Published: August 2024

This study aims to determine the community structure of benthic macroinvertebrates in the Selorejo forest. That it is hoped it can be used as a basis for evaluating water quality of river in the Selorejo forest, Dau District, Malang. Macroinvertebrate benthic samples were taken at three different stations, with three replications at each station, namely protection forest (station 1), production forest (station 2), and tourism forest (station 3). Samples were taken using a surfer's net. The samples obtained were then analyzed for wealth taxa, INP (Importance Value Index), and their diversity index which includes diversity index, uniformity index, and dominance index. In this study, 10 species were obtained from three stations; Ilyocoris sp., Stenacron interpunctatum, Hydrochara sp., Bradybaena similiaris, Hydropsyche bronta, Diphetor hageni, Dugesia tigrina, Similium vittatum, Tabanus sp. and Perlesta sp. Species with the highest tolerance level were found at stations where human activity often occurred, namely in tourist forests based on the Shannon-Wiener diversity index.
Keywords: Selorejo forest, benthic macroinvertebrates, community structure.
ABSTRAK
Penelitian ini bertujuan untuk mengetahui struktur komunitas makroinvertebrata bentos di hutan Selorejo, sehingga diharapkan nantinya dapat dijadikan dasar evaluasi kualitas air di sungai hutan Selorejo, Kecamatan Dau, Malang. Sampel makroinvertebrata bentos diambil pada tiga stasiun berbeda, dengan tiga kali ulangan pada masing-masing stasiun yaitu hutan lindung (stasiun 1), hutan produksi (stasiun 2), hutan wisata (stasiun 3). Sampel diambil dengan menggunakan jaring surber. Sampel yang sudah didapatkan selanjutnya di identifikasi untuk dianalisis kekayaan taksa/taxa richness, INP (Indeks Nilai Penting), dan indeks diversitasnya meliputi indeks keanekaragaman, indeks keseragaman, dan indeks dominansi. Pada penelitian ini didapatkan 10 speies dari ketiga stasiun yaitu Ilyocoris sp., Stenacron interpunctatum, Hydrochara sp., Bradybaena similiaris, Hydropsyche bronta, Diphetor hageni, Dugesia tigrina, Similium vittatum, Tabanus sp. dan Perlesta sp. Spesies dengan tingkat toleransi tinggi paling banyak ditemukan pada stasiun yang sering terjadi aktivitas manusia yaitu pada hutan wisata berdasarkan indeks diversitas Shannon-wiener.
Kata kunci : Hutan Selorejo, Makroinvertebrata bentos, struktur komunitas.
Aktor Perempuan Suku Laut dalam Melakukan Perubahan pada Masyarakat Suku Laut Desa Sungai Asam
Authors: Syakilla  , Wayuni Sri , Rahmawati Nanik 
Published: August 2024

This study intends to see how female actors of the Laut Tribe make changes to suku laut community in Sungai Asam village. The results of the study are that social change in suku laut community is implemented through increasing knowledge in the fields of education and health owned by suku laut community in Sungai Asam village. Initially,suku laut community in Sungai Asam village had a low level of knowledge about education and health, but now they have become suku laut women actors, especially in Desa Sungai Asam. The actions of the Suku Laut community in the development of education and health cannot be separated from the role of agents and structures. The structure is in the form of overall rules and resources in Sungai Asam village and the environment around suku laut community, while the agents are suku laut community and suku laut women. In addition, the social practice of forming social change cannot be separated from structural principles.
Assessment of CRISPRa-mediated gdnf overexpression in an In vitro Parkinson’s disease model
Authors: Guzmán-Sastoque Paula , Sotelo Sebastián , Esmeral Natalia P. , Albarracín Sonia Luz , Sutachan Jhon-Jairo , Reyes Luis H. , Muñoz-Camargo Carolina , Cruz Juan C. , Bloch Natasha I. 
Published: August 2024

IntroductionParkinson’s disease (PD) presents a significant challenge in medical science, as current treatments are limited to symptom management and often carry significant side effects. Our study introduces an innovative approach to evaluate the effects of gdnf overexpression mediated by CRISPRa in an in vitro model of Parkinson’s disease. The expression of gdnf can have neuroprotective effects, being related to the modulation of neuroinflammation and pathways associated with cell survival, differentiation, and growth.MethodsWe have developed a targeted delivery system using a magnetite nanostructured vehicle for the efficient transport of genetic material. This system has resulted in a substantial increase, up to 200-fold) in gdnf expression in an In vitro model of Parkinson’s disease using a mixed primary culture of astrocytes, neurons, and microglia.Results and DiscussionThe delivery system exhibits significant endosomal escape of more than 56%, crucial for the effective delivery and activation of the genetic material within cells. The increased gdnf expression correlates with a notable reduction in MAO-B complex activity, reaching basal values of 14.8 μU/μg of protein, and a reduction in reactive oxygen species. Additionally, there is up to a 34.6% increase in cell viability in an In vitro Parkinson’s disease model treated with the neurotoxin MPTP. Our study shows that increasing gdnf expression can remediate some of the cellular symptoms associated with Parkinson’s disease in an in vitro model of the disease using a novel nanostructured delivery system.
Identification of a novel aromatic-turmerone analog that activates chaperone-mediated autophagy through the persistent activation of p38
Authors: Motomura Kensuke , Ueda Erika , Boateng Alex , Sugiura Masaharu , Kadoyama Keiichi , Hitora-Imamura Natsuko , Kurauchi Yuki , Katsuki Hiroshi , Seki Takahiro 
Published: August 2024

Introduction: Aromatic (Ar)-turmerone is a bioactive component of turmeric oil obtained from Curcuma longa. We recently identified a novel analog (A2) of ar-turmerone that protects dopaminergic neurons from toxic stimuli by activating nuclear factor erythroid 2-related factor 2 (Nrf2). D-cysteine increases Nrf2, leading to the activation of chaperone-mediated autophagy (CMA), a pathway in the autophagy-lysosome protein degradation system, in primary cultured cerebellar Purkinje cells. In this study, we attempted to identify novel analogs of ar-turmerone that activate Nrf2 more potently and investigated whether these analogs activate CMA.Methods: Four novel analogs (A4–A7) from A2 were synthesized. We investigated the effects of A2 and novel 4 analogs on Nrf2 expression via immunoblotting and CMA activity via fluorescence observation.Results: Although all analogs, including A2, increased Nrf2 expression, only A4 activated CMA in SH-SY5Y cells. Additionally, A4-mediated CMA activation was not reversed by Nrf2 inhibition, indicating that A4 activated CMA via mechanisms other than Nrf2 activation. We focused on p38, which participates in CMA activation. Inhibition of p38 significantly prevented A4-mediated activation of CMA. Although all novel analogs significantly increased the phosphorylation of p38 6 h after drug treatment, only A4 significantly increased phosphorylation 24 h after treatment. Finally, we revealed that A4 protected SH-SY5Y cells from the cytotoxicity of rotenone, and that this protection was reversed by inhibiting p38.Conclusion: These findings suggest that the novel ar-turmerone analog, A4, activates CMA and protects SH-SY5Y cells through the persistent activation of p38.