bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a Serious Illness Communication Program for Pediatric Advance Care Planning
Authors: DeCourcey Danielle D. , Bernacki Rachelle E. , Nava-Coulter Brett , Lach Sithya , Xiong Niya , Wolfe Joanne 
Published: July 2024

ImportancePediatric advance care planning (ACP), which aims to ensure care is aligned with family goals and values, is associated with better end-of-life outcomes; however, ACP in pediatrics remains uncommon.ObjectivesTo determine the feasibility and acceptability of the Pediatric Serious Illness Communication Program (PediSICP) and explore family-centered outcomes.Design, Setting, and ParticipantsThis cohort study was a single-group pilot study of the PediSICP in adolescents and young adults (AYAs; age ≥13 y) with serious illness, parents of seriously ill children, and interprofessional clinicians from April 2021 to March 2023 in a quaternary care pediatric hospital. Duration of follow-up was 1 month. Data were analyzed from January 2022 to March 2023.ExposureThe PediSICP includes clinician training preceding an ACP communication occasion supported by communication guides and a template for electronic medical record documentation.Main Outcomes and MeasuresOutcomes of interest were parent, patient, and clinician experiences with and perceptions of the PediSICP. Feasibility was defined a priori as at least 70% clinician intervention completion rates.ResultsA total of 10 virtual trainings were conducted among 40 clinicians, including 27 physicians, 7 nurse practitioners, 5 nurses, and 1 respiratory therapist, and 30 trained clinicians (75%) conducted and documented 42 ACP conversations with 33 parents (median [IQR] age, 43 [35-51] years; 25 [76%] female) and 5 AYAs (median [IQR] age, 19 [17-19] years; 3 [60%] female) who completed the intervention. The median (IQR) conversation duration was 27 (10-45) minutes. Most clinicians (29 clinicians [97%]) agreed that they felt prepared for the conversation, and all clinicians recommended the PediSICP. Parents reported participation was worthwhile (27 parents [84%]), they felt listened to (31 parents [94%]), and would recommend the PediSICP (28 parents [85%]). Parents endorsed higher therapeutic alliance after the PediSICP intervention compared with before (The Human Connection scale mean [SD] score, 57.6 [6.4] vs 55.3 [7.8]; P = .03) and decreased anxiety immediately after the intervention (Generalized Anxiety Disorder–7-item mean [SD] score, 10.1 [7.3] vs 8.4 [6.9]; P = .003), which persisted at the 1-month follow-up (mean [SD] score, 7.7 [6.8]; P = .03).Conclusions and RelevanceThis pilot cohort study found that the PediSICP was feasible, acceptable, and highly valued by clinicians and parents of children with serious illness. These findings suggest that the PediSICP may empower interprofessional clinicians and improve ACP with families of children and AYAs who are seriously ill.
Cellulose‐Based Dual‐Network Conductive Hydrogel with Exceptional Adhesion
Authors: Shi Haoran , Huo Huanxin , Yang Hongxing , Li Hongshan , Shen Jingjie , Wan Jianyong , Du Guanben , Yang Long 
Published: July 2024

AbstractCellulose consists of a natural, rigid polymer that is widely used to improve the mechanical and water‐holding properties of hydrogels. However, its abundant hydroxyl groups make it highly absorbent to free water, leading to swelling behavior. This increased free water content will also decrease mechanical and adhesive performance. In this study, cellulose is successfully hydrophobically modified to reduce its absorption of free water. Gelatin is then cross‐linked with cellulose through a Schiff‐base reaction, resulting in increased bound water content. This significantly enhances resistance to swelling and permeability, and improves the freeze–thaw stability of the hydrogel. Due to its internal hydrophobicity, water molecules can quickly penetrate into the interior, reducing their residence time on the hydrogel surface. This allows the hydrogel to maintain high adhesion in natural environments, achieving an adhesion strength of up to 3.0 MPa on wood and bamboo‐based materials. The hydrogel can retain its adhesive properties even after prolonged exposure to a humid environment. Additionally, Na+ ions enhance the electrical conductivity and sensitivity of the hydrogel (gauge factor (GF) = 1.51), demonstrating its potential applications in flexible sensing.
Core–Shell Co‐CoxP Nanoparticle‐Embedded N‐Doped Carbon Nanowhiskers Hollow Sphere for Efficient Oxygen Evolution Electrocatalysis
Authors: Zhu Wei , Hu Wenhui , Wei Ying , Zhang Yi , Pan Kunming , Zhang Songtao , Hang Xinxin , Zheng Mingbo , Pang Huan 
Published: July 2024

AbstractThe development of efficient oxygen evolution reaction (OER) electrocatalysts is critical to overcome the efficiency bottleneck in hydrogen generation via water electrolysis. Hollow nanostructured materials have emerged as a hot topic for electrocatalysis research because of their advantages, including abundant active sites, a large contact area between the catalyst and the electrolyte, and a short transmission path. As highly efficient and stable OER electrocatalysts, cobalt‐based nanostructured materials have attracted more and more attention. In this work, cobalt metal/cobalt phosphides/nitrogen‐doped carbon composites (Co‐CoxP/NC) with a hierarchical hollow structure are designed by using hollow ZIF‐67 microspheres as precursors. By coating ZIF‐8 on the surface of hollow ZIF‐67 microspheres and further carbonizing, carbon nanowhiskers are successfully formed on the surface of hollow carbon spheres under the catalytic effect of Co nanoparticles at a high temperature. In the subsequent phosphating process, solid Co nanocrystalline particles are transformed into core–shell CoP and Co2P nanoparticles on account of the Kirkendall effect. Through the optimization of the microstructure of the material and the synergistic effect of transition metal, transition metal phosphide, and nitrogen doping, the overpotential of the optimal material is only 287 mV at 10 mA cm−2 current density in 1 m KOH.
OAM Driven Nucleation of Sub‐50 nm Compact Antiferromagnetic Skyrmions
Authors: Mallick Sougata , Ye Peng , Boutu Willem , Gauthier David , Merdji Hamed , Bibes Manuel , Viret Michel , Bouzehouane Karim , Cros Vincent 
Published: July 2024

AbstractOwing to their high mobility and immunity to topological deflection, skyrmions in antiferromagnetic (AFM) systems are gaining attention as a potential solution for next‐generation magnetic data storage. Synthetic antiferromagnets (SAFs) offer a promising avenue to tune the properties of the individual magnetic layers, facilitating the conditions necessary for skyrmions to be used in practical devices. Despite recent advancements achieving fast skyrmion mobility, the nucleation of small and rigid circular skyrmions without an external field remains challenging in SAFs. Theoretical predictions suggest that optical vortex (OAM) beams can stabilize skyrmionic spin textures by transferring their spin and orbital angular momentum to the magnetic material. Here, this intriguing proposal is delved into and the creation of sub‐50 nm compact skyrmions in SAFs using OAM beams is successfully demonstrated, eliminating the need for external magnetic fields. Additionally, the results underscore the importance of beam energy and the number of pulses, as both factors play critical roles in the stabilization of these AFM skyrmionic textures. This breakthrough is significant as it paves the way for stabilizing true zero‐field skyrmions in AFM systems, where magnetization is minimally affected by external magnetic fields. This work will open a potential avenue for stabilizing small, compact skyrmions in antiferroic systems, facilitating their implementation in logic and memory devices.
Hydrophobic and Adhesive Elastomer Encapsulation for Anti‐Drying, Non‐Swelling, and Adhesive Hydrogels
Authors: Yuan Huixin , Zhu Tang , Huang Yuchan , Wang Zefan , Han Pei , Tan Liru , Wu Jiayi , Chen Xiaochun , Yao Pingping , Zhu Caizhen , Xu Jian 
Published: July 2024

AbstractTraditional hydrogels often face issues like dehydration, excessive swelling, and poor adhesion, limiting their practical applications. This study presents a facile and universal method to create elastomer‐encapsulated hydrogels with improved water retention, non‐swelling, and enhanced adhesion. n‐Butyl acrylate (BA) and 2,2,3,4,4,4‐hexafluorobutyl methacrylate (HFBMA) are utilized as the “soft” and “hard” monomers, respectively, to in situ construct the elastomer coatings on the hydrogel surface through surface‐confined copolymerization. The resulting transparent, hydrophobic, and adhesive elastomer coating is tightly bound to the hydrogel surface, conferring upon it a robust defense against dehydration and swelling in various media, and strong adhesion to diverse substrates in both aerial and submerged conditions. Furthermore, this encapsulation strategy also augments the mechanical attributes of the bulk hydrogel, including its tensile properties and puncture resistance, and is applicable to a wide array of hydrogel types and configurations. Additionally, the in situ encapsulation method applied to conductive hydrogels results in flexible sensors with high sensitivity, reversible resistance change, exceptional sensing stability, and significantly enhanced durability in both air and underwater environments. These properties suggest potential applications in harsh environments, such as underwater acoustic detection and sonar scanning camouflage for submarines.
An Immunomodulator‐Boosted Lactococcus Lactis Platform For Enhanced In Situ Tumor Vaccine
Authors: Sun Mengna , Shi Tianyu , Tuerhong Subiyinuer , Li Mengru , Wang Qiaoli , Lu Changchang , Zou Lu , Zheng Qinghua , Wang Yingxin , Du Juan , Li Rutian , Liu Baorui , Meng Fanyan 
Published: July 2024

AbstractIn situ vaccination is an attractive type of cancer immunotherapy, and methods of persistently dispersing immune agonists throughout the entire tumor are crucial for maximizing their therapeutic efficacy. Based on the probiotics usually used for dietary supplements, an immunomodulator‐boosted Lactococcus lactis (IBL) strategy is developed to enhance the effectiveness of in situ vaccination with the immunomodulators. The intratumoral delivery of OX40 agonist and resiquimod‐modified Lactococcus lactis (OR@Lac) facilitates local retention and persistent dispersion of immunomodulators, and dramatically modulates the key components of anti‐tumor immune response. This novel vaccine activated dendritic cells and cytotoxic T lymphocytes in the tumor and tumor‐draining lymph nodes, and ultimately significantly inhibited tumor growth and prolonged the survival rate of tumor‐bearing mice. The combination of OR@Lac and ibrutinib, a myeloid‐derived suppressor cell inhibitor, significantly alleviated or even completely inhibited tumor growth in tumor‐bearing mice. In conclusion, IBL is a promising in situ tumor vaccine approach for clinical application and provides an inspiration for the delivery of other drugs.
Superatomic Layer of Cubic Mo4S4 Clusters Connected by Cl Cross‐Linking
Authors: Nakanishi Yusuke , Kanda Naoyuki , Aizaki Motoki , Hirata Kaito , Takahashi Yasufumi , Endo Takahiko , Lin Yung‐Chang , Senga Ryosuke , Suenaga Kazu , Aoyagi Shinobu , Maruyama Mina , Gao Yanlin , Okada Susumu , Miyata Yasumitsu , Liu Zheng 
Published: July 2024

AbstractSuperatomic clusters – assemblies of atoms with various sizes, shapes, and compositions – can form hierarchical architectures that exhibit emergent electronic properties not found in their individual units. In particular, cubic M4X4 clusters of chalcogenides (M = transition metal; X = chalcogen) are recognized as versatile building blocks for 3D structures with tunable morphologies and electronic properties. However, tetrahedral M4X4 clusters rarely assemble into 2D architectures, which could offer a distinct class of functional materials from their 3D analogues. Here, this work reports the preparation of 2D Mo8S8Cl11, a superatomic layer with a sandwich structure consisting of Mo4S4 clusters interconnected through Cl cross‐linking. The vapor‐phase reaction inside nanotubes promotes the selective growth of Mo8S8Cl11 nanoribbons, allowing detailed characterization via transmission electron microscopy. This methodology can be applied to the growth of layered structures containing Mo8S8Cl11 at the micrometer scale. This work has demonstrated that mono‐ and few‐layer Mo8S8Cl11 can be prepared by exfoliation of parent solids. Electronic structure calculations indicate that the 2D monolayer has quasi‐flat bands, giving rise to an indirect‐to‐direct bandgap transition under mechanical strain. Furthermore, scanning electrochemical microscopy reveals the potential of the layered structures as highly efficient catalysts for the hydrogen‐evolution reaction.
Breaking the Saturation of Sensitivity for Ultrawide Range Flexible Pressure Sensors by Soft‐Strain Effect
Authors: Li Yue , Zhang Weijie , Zhao Cheng , Li Weiwei , Dong Enchun , Xu Manzhang , Huang He , Yang Yabao , Li Lei , Zheng Lu , Mao Mao , Yao Shuxin , Wang Ling , Ma Jianbing , Wang Xuewen , Huang Wei 
Published: July 2024

AbstractThe flexible pressure sensors with a broad pressure range and unsaturated sensitivity are highly desired in practical applications. However, pressure sensors by piezoresistive effect are always limited by the compressibility of sensing layers, resulting in a theoretically decreasing sensitivity of less than 100%. Here, a unique strategy is proposed that utilizes the strain effect, simultaneously achieving a trade‐off between a wider pressure detection range and unsaturated sensitivity. Ascribed to the strain effect of sensing layers induced by interlaced microdomes, the sensors possess an increased sensitivity (5.22–70 MPa−1) over an ultrawide pressure range (45 Pa–4.1 MPa), a high‐pressure resolution (5 Pa), fast response/recovery time (30/45 ms), and a robust response under a high‐pressure loading of 3.5 MPa for more than 5000 cycles. These superior sensing performances allow the sensor to monitor large pressure. The flexible pressure sensor array can assist doctors in restoring the neutral mechanical axis, tracking knee flexion angles, and extracting gait features. Moreover, the flexible sensing array can be integrated into the joint motion surveillance system to map the balance medial–lateral contact forces on the metal compartments in real time, demonstrating the potential for further development into precise medical human–machine interfaces during total knee replacement surgery.
Chiral Co‐Assembly with Narrowband Multi‐Resonance Characteristics for High‐Performance Circularly Polarized Organic Light‐Emitting Diodes
Authors: Guo Chen‐Hao , Zhang Yuewei , Zhao Wen‐Long , Tan Ke‐Ke , Feng Liheng , Duan Lian , Chen Chuan‐Feng , Li Meng 
Published: July 2024

AbstractA promising kind of ternary chiral co‐assemblies with high PLQY, large dissymmetry factor (glum), and narrowband multi‐resonance characteristics are achieved by codoped‐thermal annealing treatments of achiral luminescent polymer F8BT, chiral inducers R/S‐5011, and achiral FRET acceptor DBN‐ICZ. The optimized co‐assemblies (F8BT)0.9‐(R/S‐5011)0.1‐(DBN‐ICZ)0.005 display narrowband yellow emission with full‐width half maximum (FWHM) of 37 nm, PLQY of 79%, and intense CPL signals with |glum| of up to 0.26. Meaningfully, solution‐processed CP‐OLEDs by using those ternary chiral co‐assemblies as emitting layer are successfully fabricated, which display yellow circularly polarized electroluminescence (CPEL) with EQEmax of 4.6% and gEL of up to 0.16. The corresponding Q‐factor could reach up to 7.36 × 10−3, which is the highest of all the reported CP‐OLEDs. Moreover, the devices also exhibit excellent comprehensive device performance with low Von of 7.0 V, high Lmax of about 25 000 cd m−2, extremely low efficiency roll‐off with EQE of 4.3% at 10 000 cd m−2, as well as narrowband EL with FWHM of only 39 nm. The proposed ternary co‐assembly strategy in fabricating CP‐OLED provides the possibility to achieve high comprehensive device performance such as balancing high EQE and large gEL value, as well as narrowband emission, high brightness and low efficiency roll‐off simultaneously.
A Soft‐Fiber Bioelectronic Device with Axon‐Like Architecture Enables Reliable Neural Recording In Vivo under Vigorous Activities
Authors: Tang Chengqiang , Han Zhengqi , Liu Ziwei , Li Wenjun , Shen Jiahao , Zhang Kailin , Mai Shuting , Li Jinyan , Sun Xiao , Chen Xingfei , Li Hongjian , Wang Liyuan , Liang Jiaheng , Liao Meng , Feng Jianyou , Wang Chuang , Wang Jiajia , Ye Lei , Yang Yiqing , Xie Songlin , Shi Xiang , Zeng Kaiwen , Zhang Xuefeng , Cheng Xiangran , Zhang Kun , Guo Yue , Yang Han , Xu Yifei , Tong Qi , Yu Hongbo , Chen Peining , Peng Huisheng , Sun Xuemei 
Published: July 2024

AbstractImplantable neural devices that record neurons in various states, including static states, light activities such as walking, and vigorous activities such as running, offer opportunities for understanding brain functions and dysfunctions. However, recording neurons under vigorous activities remains a long‐standing challenge because it leads to intense brain deformation. Thus, three key requirements are needed simultaneously for neural devices, that is, low modulus, low specific interfacial impedance, and high electrical conductivity, to realize stable device/brain interfaces and high‐quality transmission of neural signals. However, they always contradict each other in current material strategies. Here, a soft fiber neural device capable of stably tracking individual neurons in the deep brain of medium‐sized animals under vigorous activity is reported. Inspired by the axon architecture, this fiber neural device is constructed with a conductive gel fiber possessing a network‐in‐liquid structure using conjugated polymers and liquid matrices and then insulated with soft fluorine rubber. This strategy reconciles the contradictions and simultaneously confers the fiber neural device with low modulus (300 kPa), low specific impedance (579 kΩ µm2), and high electrical conductivity (32 700 S m−1) – ≈1–3 times higher than hydrogels. Stable single‐unit spike tracking in running cats, which promises new opportunities for neuroscience is demonstrated.
Domino Doyle‐Kirmse/Claisen‐Thioimidate Rearrangements: Access to 2‐Aminobuta‐1,3‐diene Derivatives of Benzazole‐2‐thiones
Authors: Rognan Charlou , Locquet Pierre , Pertschi Romain , Girard Nicolas , Gulea Mihaela 
Published: July 2024

AbstractA domino sequence consisting of a rhodium‐catalyzed Doyle‐Kirmse rearrangement followed by a Claisen‐thioimidate rearrangement has been developed. This type of thio‐Claisen rearrangement represents the first example reported in the homoallenylsulfenyl series. The sequence involves 2‐propargylsulfenyl benzazoles and diazoesters, affording N‐butadienyl substituted benzazole‐2‐thiones as a mixture of Z and E isomers, in yields ranging from 12% to quantitative (32 examples). The method provides a rapid access to a new family of highly substituted polyfunctionalized 2‐aminobuta‐1,3‐dienes with potential synthetic applications.
A comparative analysis of radiation exposure in endoscopic ultrasound‐guided drainage versus endoscopic transpapillary drainage for acute cholecystitis
Authors: Mandai Koichiro , Inoue Takato , Nakamura Shiho , Yoshimoto Takaaki , Ogawa Tomoya , Uno Koji , Yasuda Kenjiro 
Published: July 2024

AbstractCurrently, reports comparing radiation exposure associated with endoscopic transpapillary gallbladder drainage (ETGBD) and endoscopic ultrasound‐guided gallbladder drainage (EUS‐GBD) for acute cholecystitis are lacking. Therefore, we aimed to evaluate the radiation exposure during ETGBD and EUS‐GBD. We retrospectively investigated patients with acute cholecystitis who underwent ETGBD or EUS‐GBD between January 2020 and September 2023. All procedures were performed using the same fluoroscopy device with an overcouch x‐ray tube. Parameters such as fluoroscopy time, number of radiographs, and estimated entrance surface dose were assessed for radiation exposure. After excluding patients with choledocholithiasis or acute cholangitis, a comparative analysis of patient characteristics and procedural outcomes was performed between the ETGBD and EUS‐GBD groups. Forty‐four patients (21 and 23 in the ETGBD and EUS‐GBD groups, respectively) were assessed. Although there was no significant difference in patients with an American Society of Anesthesiologists physical status ≥3 between the groups, the EUS‐GBD group had a higher proportion of older patients than the ETGBD group. The EUS‐GBD group demonstrated a shorter procedure time (38 vs. 59 min, p < .001), shorter fluoroscopy time (964 vs. 1829 s, p < .001), fewer radiographs (22.9 vs. 28.4 images, p < .001), and lower estimated entrance surface dose (85.2 vs. 149.3 mGy, p < .001) compared to the ETGBD group. The EUS‐GBD group had a higher procedural success rate than the ETGBD group (100% vs. 57.1%, p < .001), with no significant difference in the incidence of early adverse events (17.4% vs. 9.5%, p = .67). In patients with permanent stenting, the 1‐year cumulative incidence of symptomatic late adverse events (recurrence of acute cholecystitis and other adverse events) was significantly lower in the EUS‐GBD group than in the ETGBD group (p = .045). In patients without concurrent bile duct stones or cholangitis, EUS‐GBD demonstrated shorter procedure and fluoroscopy times, required fewer radiographs, and had a significantly higher procedural success rate than ETGBD.
Catatonia responsive to corticosteroids in a patient with an SCN2A variant
Authors: Senko Kimberly , Saddoris Kelsey L. , Baus Ella , Soe Katherine , Vaughn Samuel E. 
Published: July 2024

AbstractVariants in SCN2A are a known risk factor for developing autism spectrum disorder (ASD). Catatonia is a complex neuropsychiatric syndrome, which occurs at a higher rate in individuals with ASD. Catatonia has also been associated with COVID‐19 infection, though the majority of these cases are associated with increased serum inflammatory markers. We present a case of a 15‐year‐old female with ASD and corticosteroid responsive stuporous catatonia to explore the relationship between SCN2A variants, ASD, COVID‐19 exposure, and treatment refractory catatonia. Despite a lack of significantly elevated serum or CSF inflammatory markers, this patient showed significant improvement following initiation of corticosteroid therapy. This case presents a novel approach to the work‐up and treatment of catatonia in individuals with SCN2A variants independent of elevated inflammatory markers.
One Iron for Two Iron Sites in a Metal–Organic Framework Toward Simultaneous N2−H2 Activation under Mild Conditions
Authors: Liu Xize , He Xingyue , Li Bo , Liu Xiao , Luo Haiqiang , Ma Jian‐Gong , Cheng Peng 
Published: July 2024

AbstractIron‐based catalysts play an important role in the ammonia industry. As one of the most abundant iron minerals, Fe3O4 containing FeII and FeIII sites is widely distributed in the earth's crust and even on exoplanets, theoretically giving it both economic and catalytic potentials in ammonia synthesis. However, in the absence of specific active co‐catalyst and harsh conditions, Fe3O4 is impossible to achieve ammonia synthesis alone. Here, we designed to activate the relatively inert FeII and FeIII sites in Fe3O4 with a third FeIII site inlayed in a coordination framework (MIL‐101(Fe)) to achieve the unpresented multi‐site collaborative catalysis. In‐depth mechanism study confirmed the roles of three different Fe sites in N2 activation, H2 activation, and product transfer, respectively. Efficient N2−H2 activation to NH3 on the Fe3O4‐based catalytic system has been achieved at extremely mild conditions. Our research provides a theoretical basis and a new strategy for designing efficient non‐noble metal‐based ammonia synthesis catalyst with minimized energy consumption.