bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of the Acute Inpatient Medicine—High Reliability, Learning Environment, and Workforce Development Initiative (AIM‐HI) in rural Veterans Health Administration hospitals: A mixed methods evaluation protocol
Authors: Gilmartin Heather M. , Connelly Brigid , Daus Marguerite , Hess Edward , Leonard Chelsea , Morgan Brianne , Nolan John P. , Perry Paige , Sjoberg Heidi , Subramaniam Soumya , Anderson Melver L. 
Published: August 2024

AbstractIntroductionFew rural hospital medicine programs include workforce development training that provides social and professional support for interdisciplinary teams. Even fewer include training that creates supportive learning environments that result in higher staff satisfaction, lower burnout, and reduced turnover. The Acute Inpatient Medicine—High Reliability, Learning Environment, and Workforce Development Initiative (AIM‐HI) aims to create supportive learning environments in Veterans Health Administration (VA) rural hospital medicine teams.MethodsAIM‐HI is a type II hybrid implementation study utilizing a convergent mixed methods approach to evaluate the Relational Playbook, a workforce development intervention, and three implementation strategies: behavioral nudges, learning and leadership collaboratives, and leadership coaching. AIM‐HI implementation will occur in waves, enrolling additional hospitals every 12 months. In the first wave, AIM‐HI will be implemented at three tertiary VA hospitals that treat at least 1000 rural Veterans annually and have an active inpatient hospital medicine program. The primary outcomes in year 1 will be the acceptability, appropriateness, and feasibility of AIM‐HI assessed through participant surveys and interviews. In subsequent years, trends in the learning environment, job satisfaction, burnout, and turnover scores will be assessed using a linear mixed‐effect model.DiscussionThe anticipated impact of AIM‐HI is to evaluate the utility of the implementation strategies and assess trends in Playbook intervention outcomes. The Playbook has strong face validity; however, before large‐scale adoption across the VA enterprise, it is essential to establish the acceptability, appropriateness, and feasibility of the Playbook and implementation strategies, as well as to gather data on AIM‐HI effectiveness.
Lead‐212/Bismuth‐212 In Vivo Generator Based on Ultrasmall Silver Telluride Nanoparticles
Authors: Wang Runze , Wolterbeek Hubert Th. , Denkova Antonia G. 
Published: August 2024

ABSTRACTRadionuclide therapy employing alpha emitters holds great potential for personalized cancer treatment. However, certain challenges remain when designing alpha radiopharmaceuticals, including the lack of stability of used radioconjugates due to nuclear decay events. In this work, ultrasmall silver telluride nanoparticles with a core diameter of 2.1 nm were prepared and radiolabeled with lead‐212 using a chelator‐free method with a radiolabeling efficiency of 75%. The results from the in vitro radiochemical stability assay indicated a very high retention of bismuth‐212 despite the internal conversion effects originating from the decay of 212Pb. To further evaluate the potential of the nanoparticles, they were radiolabeled with indium‐111, and their cell uptake and subcellular distribution were determined in 2D U87 cells, showing accumulation in the nucleus. Although not intentional, it was observed that the indium‐111‐radiolabeled nanoparticles induced efficient tumor cell killing, which was attributed to the Auger electrons emitted by indium‐111. Combining the results obtained in this work with other favorable properties such as fast renal clearance and the possibility to attach targeting vectors on the surface of the nanoparticles, all well‐known from the literature, these ultra‐small silver telluride nanoparticles provide exciting opportunities for the design of theragnostic radiopharmaceuticals.
Gaucher disease type 3c: Expanding the clinical spectrum of an ultra‐rare disease
Authors: Wang John S. , Koch Rebecca L. , Kenney‐Jung Daniel , Huggins Erin , Sodhi Sirajbir S. , Landstrom Andrew P. , Grewal Dilraj S. , Kishnani Priya S. 
Published: August 2024

AbstractGaucher disease (GD) type 3 is an autosomal recessive lysosomal disease caused by deficiency of β‐glucocerebrosidase (GCase) and encompasses a spectrum of cardiac, neurological, and ophthalmological abnormalities. Although the clinical presentations can be diverse, a recognized clinical trajectory points to an early onset, predominantly before 18 years. GD type 3c is primarily caused by homozygosity for GBA pathogenic variant c.1342G>C (p.Asp448His; historically referred to as D409H) and includes visceral, hematological, skeletal, and cardiac abnormalities. Notably, GD type 3c is distinct from other GD types because it is primarily characterized by valvular heart disease. Yet, with less than 50 patients with GD type 3c reported to date, the phenotypic spectrum and extent of cardiac involvement remains ill‐defined. We present a 20‐year‐old female with an atypical presentation of GD type 3c consisting of chronic intermediate uveitis as the presenting feature and the presence of extensive polyneuropathy starting in adolescence which has been previously unreported in GD type 3c. Distinctively, she has maintained normal cardiac function. Moreover, we compare our case with those reported in the literature to broaden awareness of the varied initial presentations of this disease. The diverse presentations seen in GD type 3c, underscored by our case and those previously reported, demonstrate the need for standardized evaluation and management protocols.
Bacterial Extracellular Vesicles: Potential Therapeutic Applications, Challenges, and Future Prospects
Authors: Humaira  , Ahmad Irfan , Shakir Hafiz Abdullah , Khan Muhammad , Franco Marcelo , Irfan Muhammad 
Published: August 2024

ABSTRACTAlmost all cell types naturally secret extracellular vesicles (EVs) in the extracellular space with variable metabolic cargo facilitating intracellular communication, posing immune‐modulation capacity. Thus, “bacterial extracellular vesicles” (BEVs), with their great immunoregulatory, immune response stimulation and disease condition‐altering potential, have gained importance in the medical and therapeutic industry. Various subtypes of BEVs were observed and reported in the literature, such as exosomes (30–150 nm), microvesicles (100–1000 nm), apoptotic bodies (1000–5000 nm), and oncosomes (1000–10,000 nm). As biological systems are complex entities, inserting BEVs requires extra high purity. Various techniques for BEV isolation have been employed alone or with other strategies, such as ultracentrifugation, precipitation, size‐exclusion chromatography, affinity‐based separation, ultrafiltration, and field‐flow fractionation. But to date, no BEV isolation method is considered perfect as the lack of standard protocols limits their scale‐up. Medical research has focused on BEVs to explore their diverse therapeutic potential. This review particularly focused on the recent advancements in the potential medical application of BEVs, current challenges, and prospects associated with their scale‐up.
The rental‐function effect: How does product acquisition mode affect consumer preference relating to product attributes?
Authors: Liu Wumei , Kang Na , Song Pengfei 
Published: August 2024

AbstractPurchasing and renting are two basic modes for consumers to acquire a product. While prior research has investigated which factors affect consumers' choice of renting versus purchasing a product, very limited research studies the outcome of renting versus purchasing a product. Extending this line of research, this paper links product acquisition mode to product attribute preference. Specifically, through a series of eight multimethod studies, including secondary data study, field experiment, and lab experiments, we show that renting a product, as compared to purchasing a product, increases consumers' focus on the product's feasibility aspect rather than its desirability aspect, which in turn drives consumers to prefer the product option with superior function over the one with superior appearance. Furthermore, we show that this rental‐function effect amplifies (attenuates) when the product's brand image is positioned as a mass brand (a luxury brand). This paper uncovers a novel finding of renting products. It also provides practical guidelines for rental companies and marketing managers on how to effectively position their products and optimize advertising strategies.
Room‐Temperature Self‐Healing and Recyclable Self‐Crosslinked Isosorbide‐Based Adhesive Bioelastomer
Authors: Ouyang Qing , Du Ming‐Xuan , Xiao Yao‐Nan , Wu Shao‐Hua , Zhang Bo , Liu Jia‐Jian , Li Chun‐Cheng 
Published: August 2024

AbstractRecently, renewable bio‐based materials have received more and more attention due to environmental issues such as global warming and ecosystem destruction. In the present work, a series of isosorbide‐based bioelastomers poly(isosorbide carbonate‐co‐butanediol aliphatic esters)s (PICBAs) are synthesized by a facile and economical two‐step melt polycondensation. Due to the slightly self‐crosslinking reaction of isosorbide, PICBAs exhibit excellent tensile strength and self‐healing ability, the mechanical properties of PICBAs can recover over 95% after 48 h under room temperature. In addition, PICBAs can stick different substances, such as glass, rubber, plastic, and stones, and show better adhesive performance than 3M commercially available double‐sided tape. Consequently, isosorbide‐based bioelastomers PICBAs are of great potential to be used as environmentally friendly pressure‐sensitive adhesives (PSA) in the future.
ROR2 promotes cell cycle progression and cell proliferation through the PI3K/AKT signaling pathway in gastric cancer
Authors: Liu Qi , Zhao Xin , Shao Xiaowen , Cheng Ping , Cui Jingyi , Han Shuyi 
Published: August 2024

AbstractProliferation is a critical characteristic of the progression of gastric cancer (GC). Receptor tyrosine kinase‐like orphan receptor 2 (ROR2), the orphan receptor tyrosine kinase‐like receptor, exhibits effects on tumor growth due to its abnormal expression in cancer. The goal of our study was to assess the potential regulatory role exerted by the ROR2 on GC cells. Through previous bioinformatics analysis, we discovered an association between ROR2 and the G2/M phase of the GC cell cycle. However, little is known about the link between ROR2 and the G2/M phase cell cycle in GC. Here, the findings of our study indicate that ROR2, after transcribed expression by Twist1, activates the PI3K/AKT/mTOR/S6K signal transduction pathway, thus leading to the acceleration of the G2/M phase and subsequent promotion of cell proliferation in GC. Furthermore, the functional link among ROR2, Twist1, and G2/M phase of cell cycle was also confirmed in mouse xenograft tissues and human tissues. ROR2 expression was correlated with Twist expression and lower survival in vivo. Notably, our suggestion is that focusing on ROR2 as a potential therapeutic approach could show potential for the management of GC.
Time‐of‐Day Adrenal Modulation of Corticosterone Synthesis is Affected by Sex and Diet but Not by Proanthocyanidins in Rat
Authors: Romero Maria‐del‐Mar , Martín‐González Miguel Z. , Aragonès Gerard , Muguerza Begoña , Remesar Xavier , Arola‐Arnal Anna , Fernández‐López José‐Antonio 
Published: August 2024

ScopeThe aim of this study is to investigate the effect of time‐of‐day on serum hormones and gene expression in adrenal glands, studying the impact of sex, obesogenic diet, and timing of proanthocyanidins administration, with a focus on glucocorticoids synthesis by this gland.Methods and resultsFemale and male rats, assigned to a standard chow or a cafeteria diet‐fed group, receive a daily oral dose of a grape seed proanthocyanidin extract (GSPE), or a vehicle (when light is turned on, or when light is turned off). Corticosterone, estradiol, and testosterone serum levels, and the expression analysis of clock genes and genes related to corticosterone synthesis pathway, are assessed. Serum hormone levels exhibited a marked time‐of‐day effect also see in the expression of scavenger receptor class B member 1 (Scarb1) and cyp11b genes. The correlation between these two genes and period circadian regulator 2 (Per2) is also extended to other clock genes, although to a lesser extent: cryptochrome (Cry) and nuclear receptor subfamily 1 group D member 1 (Rev‐erba).ConclusionThe strong correlations found suggest an important role of local Per2 (but also of Cry and Rev‐erbA) in regulating the expression of the enzymes involved in the corticosterone synthesis pathway. The expression of clock genes in adrenals is influenced by sex and diet but not by GSPE.
The SDF‐1/CXCR4 axis is involved in adipose‐derived stem cell migration
Authors: Li Jiang , Deng Tibin , Zhu Shaojie , Xie Pingbo , Wang Wei , Zhou Hongqing , Xu Chenxiang 
Published: August 2024

AbstractBackgroundIntravenous injection of adipose‐derived stem cells (ADSCs) can improve the urinary function of stress urinary incontinence (SUI) model rats and C‐X‐C chemokine receptor type 4 (CXCR4)‐positive ADSCs are found in urethral tissues. The CXCR4 ligand stromal cell‐derived factor‐1 (SDF‐1) is highly expressed in urinary incontinence model rats. In this study, we investigated the involvement of the SDF‐1/CXCR4 axis in the homing of ADSCs.MethodsADSCs were isolated from rats and purified. The levels of CXCR4 and CXCR7 were determined by western blot analysis and immunofluorescence assays following stimulation with SDF‐1. Hypoxia conditioning was performed to treat the cells in vitro, following which the messenger RNA (mRNA) and protein level of SDF‐1, CXCR4, and CXCR7 were estimated.ResultsWe found that CXCR4 and CXCR7 were expressed in ADSCs at passage zero (P0), P1, and P3, and the expression of both increased after SDF‐1 stimulation. The level of expression of the mRNAs and proteins of SDF‐1, CXCR4, and CXCR7 in ADSCs was higher after hypoxic conditioning. We then knocked down CXCR4 or CXCR7 using small interfering RNAs and found that the mRNA levels of CXCR4 and CXCR7 were considerably downregulated in the si‐CXCR4/7‐transfected cells. We also found that the SDF‐1/CXCR4 axis was required for the migration of ADSCs. The phosphorylation levels of Janus kinase (JAK), protein kinase B (AKT), and extracellular regulated protein kinase significantly increased in SDF‐1‐stimulated ADSCs. However, the migration of ADSCs was suppressed when the corresponding specific inhibitors were used to block JAK and AKT signaling or silence CXCR4, whereas no significant change was observed in the migratory ability of ADSCs when the ERK pathway was blocked or CXCR7 was silenced.ConclusionsThe SDF‐1/CXCR4 axis is involved in the migration of ADSCs and may play a role in the migrate of ADSCs in SUI.
Chemodenervation is Associated With Reduced Mental Health Disorders in Patients With Synkinesis
Authors: Lorenz Fred Jeffrey , Schopper Heather K. , Lighthall Jessyka G. 
Published: August 2024

AbstractObjectiveTo compare the prevalence of mental health disorders in individuals with facial synkinesis, facial paralysis alone, and the general population.Study DesignRetrospective cohort.SettingEighty‐two health care organizations across the United States.MethodsThe TriNetX Research Network was queried from 2011 to 2021 for patients with facial paralysis without synkinesis, facial paralysis and documented synkinesis, and controls, matched for age, sex, race, and ethnicity. Cases included infectious, iatrogenic, or idiopathic facial paralysis. Patients with pre‐existing depression or anxiety were excluded. Two‐year rates of newly diagnosed depression, anxiety, and mental health prescriptions were compared.ResultsAmong 127,573 patients with facial paralysis, 92.5% (n = 117,976) had facial paralysis alone, and 7.5% (n = 9597) also had documented synkinesis. Compared to controls, patients with facial paralysis alone had increased risks of new depression (8.9% vs 7.3%, P < .001) and anxiety (10.1% vs 9.6%, P < .001), with higher mental health medication rates (16.6% vs 13.1%, P < .001). Patients with documented synkinesis, in comparison to controls, had the highest risks of depression (19.8% vs 8.6%, P < .001), anxiety (20.5% vs 10.5%, P < .001), and prescriptions (28.1% vs 15.8%, P < .001). The 27.8% (n = 2669) of synkinetic patients treated with chemodenervation had lower rates of depression (8.5% vs 23.5%, P < .001), anxiety (9.0% vs 23.8%, P < .001), and prescriptions (21.6% vs 30.0%, P < .001) compared to synkinetic patients who were not.ConclusionFacial paralysis, particularly synkinesis, is linked to increased mental health disorders. Integrating mental health screening and treatment into a comprehensive approach is crucial. Chemodenervation is associated with decreased mental health disorders in synkinesis, highlighting its therapeutic potential.
Lingual Tonsillectomy as Part of a DISE‐Directed Multilevel Upper Airway Surgery to Treat Complex Pediatric OSA: A Safe and Appropriate Procedure
Authors: Trandafir Cornelia , Couloigner Vincent , Chatelet Florian , Fauroux Brigitte , Luscan Romain 
Published: August 2024

AbstractObjectiveTo study the efficiency of lingual tonsillectomy (LT) as part of multilevel surgery in children with complex obstructive sleep apnea (OSA). To evaluate the safety and the outcomes of LT.Study DesignRetrospective case series.SettingPediatric tertiary care academic center.MethodsWe included all children operated for LT to treat complex OSA, from January 2018 to June 2022. All patients underwent a protocolized drug‐induced sleep endoscopy (DISE) followed by a coblation LT, associated with the treatment of all other obstructive sites. Patient demographics, medical history, surgery, and outcomes were reviewed. The efficiency of LT was analyzed exclusively in patients with a preoperative and postoperative sleep study.ResultsOne hundred twenty‐three patients were included. Median age was 8 years (interquartile range, IQR [3‐12]). Sixty‐five (53%) patients had Down syndrome, 22 (18%) had a craniofacial malformation, and 8 (7%) were obese. LT was associated with adenoidectomy (n = 78, 63%), partial tonsillectomy (n = 70, 57%), inferior turbinoplasty/turbinectomy (n = 59, 48%), epiglottoplasty (n = 92, 75%), and/or expansion pharyngoplasty (n = 2, 2%). Eighty‐nine patients underwent a sleep study before and after surgery. The median apnea‐hypopnea index (AHI) decreased from 18 events/h (IQR [9‐36]) before surgery to 3 events/h (IQR [1‐5]) after surgery (P < .001) (patients with a postoperative AHI <1.5 events/h, n = 31, 35%, and an AHI <5 events/h, n = 32, 36%). Seventeen out of 30 (57%) patients could be weaned from continuous positive airway pressure after surgery. Two patients had a postoperative hemorrhage and 2 patients required a transient postoperative reintubation.ConclusionIn children with complex OSA, LT as part of a DISE‐directed multilevel upper airway surgery, was a very efficient and safe procedure.
Effectiveness of marsupialization on the reduction of cystic jaw lesions in children: A scoping review
Authors: Tran Thao Phuong , Ngoc Vo Truong Nhu , Linh Le Ngoc Phuong , Le Anh Kha 
Published: August 2024

AbstractThis study aimed to review and critically appraise the available literature concerning marsupialization's effectiveness in reducing cystic jaw lesions in children. The study conducted a search strategy that involved combining the following keywords: (1) children, (2) marsupialization, (3) jaw, and (4) cyst. An electronic search on four critical databases—PubMed, The Cochrane Library, Science Direct, and ResearchGate—to review English‐language articles with no limitations in terms of time, sample size, or type of study design has been conducted. Based on the inclusion and exclusion criteria applied to the preliminary search, 46 studies were included in the final review. Among the 194 identified lesions, the majority were dentigerous cysts (93.8%), followed by radicular cysts (2.6%), odontogenic keratocysts (1.6%), juvenile paradental cysts (1%), and calcifying odontogenic cysts (1%). Postoperatively, permanent teeth involved in the cysts were reported to develop continuously in 40 studies, whereas bone neo‐formation after removal of cystic lesions was reported in 30 studies. Only one study reported postoperative recurrence. The complete healing time of the cysts after marsupialization ranged from 6 months to 5 years. Marsupialization was mainly considered a definite treatment. Because of the long follow‐up period, the cooperation of the patient and family plays an essential role in the success of treatment.
Cross‐sectional study on university students' mental health during the COVID‐19 pandemic: Exploring the influence of adverse and positive childhood experiences
Authors: Noda Tetsuro , Nagaura Hiromu , Fujita Yoshinobu , Tsutsumi Toshihiko 
Published: August 2024

AbstractAimThis study examined the psychological impact of the COVID‐19 pandemic on university students, focusing on how adverse childhood experiences (ACEs) and positive childhood experiences (PCEs) influence mental health.MethodsA web‐based survey was administered to 3000 university students from October 26 to 31, 2022, following the peak of the COVID‐19 pandemic. Mental health assessments included the Japanese version of the Kessler Psychological Distress 6‐Item Scale (K6) for depressive/anxiety symptoms, the Impact of Event Scale‐Revised (IES‐R‐J) for distress, fear of COVID‐19, and a three‐item loneliness scale.ResultsOf the respondents, 46.9% reported depressive/anxiety symptoms, 55.4% reported distress, and 37.3% reported fear of COVID‐19. Factors such as current psychiatric treatment history and reduced income (either parental or personal) were predictive of worsening depressive/anxiety symptoms, distress, and loneliness. ACEs were found to exacerbate depressive/anxiety symptoms and distress, while PCEs mitigated these symptoms, and vice versa.ConclusionThis study underscores the importance of considering both ACEs and PCEs in supporting the mental health of university students. PCEs were found to independently prevent mental health deterioration, including depressive/anxiety symptoms and distress, which may include post‐traumatic stress disorder symptoms, even in the presence of ACEs. Recognizing and fostering PCEs emerged as an effective strategy for mitigating mental health issues.