bluuebunny/crossref_metadata_2025_split huggingface dataset:
HANS KELLER, NIKOS SKALKOTTAS AND THE NOTION OF SYMPHONIC GENIUS
Authors: Mantzourani Eva 
Published: January 2013

AbstractIn his writings on music Hans Keller includes Skalkottas among the few great twentieth-century composers of ‘symphonic thought’, and considers him to be the only ‘symphonic genius’ after Schoenberg whose ‘genius’ remains to be discovered. Although during the time of his writings, Keller was in a minority in his appreciation of this relatively minor composer in the Western art music canon, he did not analyse any of Skalkottas's music in support of his views, as he did with the works of other composers who, although important to him, are not elevated to such a high plane. This paper first gives an overview of Keller's approach to and understanding of symphonic thought, as presented in his various writings and exemplified in his analyses of Schoenberg's music. Subsequently, it examines certain of Skalkottas's 12-note works and the compositional techniques he applies to construct them, which exhibit these characteristics of symphonic thought defined by Keller, and which might be used to substantiate his unexplained but intuitively correct assertions.
EMEN2: An Object Oriented Database and Electronic Lab Notebook
Authors: Rees Ian , Langley Ed , Chiu Wah , Ludtke Steven J. 
Published: January 2013

AbstractTransmission electron microscopy and associated methods, such as single particle analysis, two-dimensional crystallography, helical reconstruction, and tomography, are highly data-intensive experimental sciences, which also have substantial variability in experimental technique. Object-oriented databases present an attractive alternative to traditional relational databases for situations where the experiments themselves are continually evolving. We present EMEN2, an easy to use object-oriented database with a highly flexible infrastructure originally targeted for transmission electron microscopy and tomography, which has been extended to be adaptable for use in virtually any experimental science. It is a pure object-oriented database designed for easy adoption in diverse laboratory environments and does not require professional database administration. It includes a full featured, dynamic web interface in addition to APIs for programmatic access. EMEN2 installations currently support roughly 800 scientists worldwide with over 1/2 million experimental records and over 20 TB of experimental data. The software is freely available with complete source.
Precision CMB Measurements from Long Duration Stratospheric Balloons: Towards B-modes and Inflation
Authors: Jones William C. 
Published: January 2013

AbstractObservations of the Cosmic Microwave Background (CMB) have played a leading role in establishing an understanding of the structure and evolution of the Universe on the largest scales. This achievement has been enabled by a series of extremely successful experiments, coupled with the simplicity of the relationship between the cosmological theory and data. Antarctic experiments, including both balloon-borne telescopes and instruments at the South Pole, have played a key role in realizing the scientific potential of the CMB, from the characterization of the temperature anisotropies to the detection and study of the polarized component. Current and planned Antarctic long duration balloon experiments will extend this heritage of discovery to test theories of cosmic genesis through sensitive polarized surveys of the millimeter-wavelength sky. In this paper we will review the pivotal role that Antarctic balloon borne experiments have played in transforming our understanding of the Universe, and describe the scientific goals and technical approach of current and future missions.
Preliminary design of the Kunlun Dark Universe Survey Telescope (KDUST)
Authors: Yuan Xiangyan , Cui Xiangqun , Su Ding-qiang , Zhu Yongtian , Wang Lifan , Gu Bozhong , Gong Xuefei , Li Xinnan 
Published: January 2013

AbstractFrom theoretical analysis and site testing work for 4 years on Dome A, Antarctica, we can reasonably predict that it is a very good astronomical site, as good as or even better than Dome C and suitable for observations ranging from optical to infrared & sub-mm wavelengths. After the Chinese Small Telescope ARray (CSTAR), which was composed of four small fixed telescopes with diameter of 145mm and the three Antarctic Survey Telescopes (AST3) with 500mm entrance diameter, the Kunlun Dark Universe Survey Telescope (KDUST) with diameter of 2.5m is proposed. KDUST will adopt an innovative optical system which can deliver very good image quality over a 2 square degree flat field of view. Some other features are: a fixed focus suitable for different instruments, active optics for miscollimation correction, a lens-prisms that can be used as an atmospheric dispersion corrector or as a very low-dispersion spectrometer when moved in / out of the main optical path without changing the performance of the system, and a compact structure to make easier transportation to Dome A. KDUST will be mounted on a tower with height 15m in order to make a full use of the superb free atmospheric seeing.
Delays in medical malpractice litigation in civil law jurisdictions: some evidence from the Italian Court of Cassation
Authors: Grembi Veronica , Garoupa Nuno 
Published: January 2013

AbstractMedical malpractice law and tort reform are contentious issues. In this paper, we focus on Italy as an example of a civil law jurisdiction. Italian medical malpractice law is essentially judge-made law. However, its effectiveness is likely to be curtailed by excessive delays in litigation. Several reforms have been enacted since the late 1980s to correct this situation. By making use of the decisions of the Italian Court of Cassation (which have shaped medical malpractice law) from 1970 to 2009, we show that these reforms had no general statistically significant impact on delays. Recent reduction of delays does not seem to be related to legal reforms but rather explained by other factors.
AdE-1, a new inotropic Na+ channel toxin from Aiptasia diaphana, is similar to, yet distinct from, known anemone Na+ channel toxins
Authors: Nesher Nir , Shapira Eli , Sher Daniel , Moran Yehu , Tsveyer Liora , Turchetti-Maia Ana Luiza , Horowitz Michal , Hochner Binyamin , Zlotkin Eliahu 
Published: January 2013

Heart failure is one of the most prevalent causes of death in the western world. Sea anemone contains a myriad of short peptide neurotoxins affecting many pharmacological targets, several of which possess cardiotonic activity. In the present study we describe the isolation and characterization of AdE-1 (ion channel modifier), a novel cardiotonic peptide from the sea anemone Aiptasia diaphana, which differs from other cnidarian toxins. Although AdE-1 has the same cysteine residue arrangement as sea anemone type 1 and 2 Na+ channel toxins, its sequence contains many substitutions in conserved and essential sites and its overall homology to other toxins identified to date is low (&lt;36%). Physiologically, AdE-1 increases the amplitude of cardiomyocyte contraction and slows the late phase of the twitch relaxation velocity with no induction of spontaneous twitching. It increases action potential duration of cardiomyocytes with no effect on its threshold and on the cell's resting potential. Similar to other sea anemone Na+ channel toxins such as Av2 (Anemonia viridis toxin II), AdE-1 markedly inhibits Na+ current inactivation with no significant effect on current activation, suggesting a similar mechanism of action. However, its effects on twitch relaxation velocity, action potential amplitude and on the time to peak suggest that this novel toxin affects cardiomyocyte function via a more complex mechanism. Additionally, Av2's characteristic delayed and early after-depolarizations were not observed. Despite its structural differences, AdE-1 physiologic effectiveness is comparable with Av2 with a similar ED50 value to blowfly larvae. This finding raises questions regarding the extent of the universality of structure–function in sea anemone Na+ channel toxins.
Microvesicles and exosomes as vehicles between protozoan and host cell communication
Authors: Deolindo Poliana , Evans-Osses Ingrid , Ramirez Marcel Ivan 
Published: January 2013

Cells release extracellular vesicles in response to external factors or in a physiological way. Microvesicles and exosomes originate in cells in different ways and, depending on their contents, may have multiple biological effects on other cells and the environment. The host cell–parasite relationship could be changed dramatically by the plasticity of a new type of communication through extracellular vesicles. In the present paper, we discuss how protozoans use this new resource to evade the immune system and establish infection.
Enlightening G-protein-coupled receptors on the plasma membrane using super-resolution photoactivated localization microscopy
Authors: Scarselli Marco , Annibale Paolo , Gerace Claudio , Radenovic Aleksandra 
Published: January 2013

The possibility to visualize and image the arrangement of proteins within the cell at the molecular level has always been an attraction for scientists in biological research. In particular, for signalling molecules such as GPCRs (G-protein-coupled receptors), the existence of protein aggregates such as oligomers or clusters has been the topic of extensive debate. One of the reasons for this lively argument is that the molecular size is below the diffraction-limited resolution of the conventional microscopy, precluding the direct visualization of protein super-structures. On the other hand, new super-resolution microscopy techniques, such as the PALM (photoactivated localization microscopy), allow the limit of the resolution power of conventional optics to be broken and the localization of single molecules to be determined with a precision of 10–20 nm, close to their molecular size. The application of super-resolution microscopy to study the spatial and temporal organization of GPCRs has brought new insights into receptor arrangement on the plasma membrane. Furthermore, the use of this powerful microscopy technique as a quantitative tool opens up the possibility for investigating and quantifying the number of molecules in biological assemblies and determining the protein stoichiometry in signalling complexes.
The ring of confidence: a haloarchaeal CRISPR/Cas system
Authors: Maier Lisa-Katharina , Stoll Britta , Brendel Jutta , Fischer Susan , Pfeiffer Friedhelm , Dyall-Smith Mike , Marchfelder Anita 
Published: January 2013

To survive the constant invasions by foreign genetic elements, prokaryotes have evolved various defensive systems. Almost all sequenced archaea, and half of the analysed bacteria use the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated) system, a recently identified prokaryotic immune system that can fend off invading elements in a sequence-specific manner. Few archaeal CRISPR/Cas systems have been analysed so far, and the molecular details of many of the steps involved in adaptation and defence are yet to be understood. In the present paper, we summarize our current knowledge about the CRISPR/Cas system in Haloferax volcanii, an extremely halophilic archaeon that was isolated from the Dead Sea. H. volcanii encodes a type I-B CRISPR/Cas system, and carries three CRISPR loci and eight Cas proteins. Although in laboratory culture for more than three decades, this defence system was shown to be still active. All three CRISPR loci are transcribed and processed into mature crRNAs (CRISPR RNAs). Cells challenged with engineered plasmids can recognize and eliminate these invading elements if they contain the correct PAM (protospacer adjacent motif) and a sequence that can be recognized by one of the CRISPR spacers.
The cis-acting signals that target proteins to exosomes and microvesicles
Authors: Yang Jr-Ming , Gould Stephen J. 
Published: January 2013

Proteins bud from cells in small single-membraned vesicles (~50–250 nm) that have the same topology as the cell. Known variously as exosomes and microvesicles (EMVs), these extracellular organelles are enriched for specific proteins, lipids, carbohydrates and nucleic acids. EMV biogenesis plays critical roles in protein quality control and cell polarity, and, once released, EMVs can transmit signals and molecules to neighbouring cells via a non-viral pathway of intercellular vesicle traffic. In the present paper, we discuss the cis-acting targeting signals that target proteins to EMVs and mediate protein budding from the cell.
Omega-3 fatty acid ethyl ester supplementation decreases very-low-density lipoprotein triacylglycerol secretion in obese men
Authors: Wong Annette T. Y. , Chan Dick C. , Ooi Esther M. M. , Ng Theodore W. K. , Watts Gerald F. , Barrett P. Hugh R. 
Published: January 2013

Dysregulated VLDL-TAG (very-low-density lipoprotein triacylglycerol) metabolism in obesity may account for hypertriacylglycerolaemia and increased cardiovascular disease. ω-3 FAEEs (omega-3 fatty acid ethyl esters) decrease plasma TAG and VLDL concentrations, but the mechanisms are not fully understood. In the present study, we carried out a 6-week randomized, placebo-controlled study to examine the effect of high-dose ω-3 FAEE supplementation (3.2 g/day) on the metabolism of VLDL-TAG in obese men using intravenous administration of d5-glycerol. We also explored the relationship of VLDL-TAG kinetics with the metabolism of VLDL-apo (apolipoprotein) B-100 and HDL (high-density lipoprotein)-apoA-I. VLDL-TAG isotopic enrichment was measured using gas chromatography-mass spectrometry. Kinetic parameters were derived using a multicompartmental model. Compared with placebo, ω-3 FAEE supplementation significantly lowered plasma concentrations of total (−14%, P&lt;0.05) and VLDL-TAG (−32%, P&lt;0.05), as well as hepatic secretion of VLDL-TAG (−32%, P&lt;0.03). The FCR (fractional catabolic rate) of VLDL-TAG was not altered by ω-3 FAEEs. There was a significant association between the change in secretion rates of VLDL-TAG and VLDL-apoB-100 (r=0.706, P&lt;0.05). However, the change in VLDL-TAG secretion rate was not associated with change in HDL-apoA-I FCR (r=0.139, P&gt;0.05). Our results suggest that the TAG-lowering effect of ω-3 FAEEs is associated with the decreased VLDL-TAG secretion rate and hence lower plasma VLDL-TAG concentration in obesity. The changes in VLDL-TAG and apoB-100 kinetics are closely coupled.
The Dutch change-of-state copulawordenand its Spanish counterparts
Authors: Hanegreefs Hilde 
Published: January 2013

By means of a contrastive corpus analysis we will examine the different translation possibilities in Spanish for the Dutch change-of-state copulaworden. Unlike English or French, Spanish does not have a single verb to translate the Dutch copulaworden, but instead displays a whole range of possibilities to express change. In the present study, we will focus on the three Spanish predicates that – in our corpus – are most frequently used to translate the attributive construction withworden, viz. A semi-copula, a lexical verb and a simple copula (serorestar ‘to be’).
Our data will reveal that the selection of an appropriate translation of worden is not random. On the contrary, a different translation category corresponds to a different conceptualization of the process of change. A variety of contextual, formal and semantic factors can help explain the preference for one translation possibility over the other.
MetaNetX.org: a website and repository for accessing, analysing and manipulating metabolic networks
Authors: Ganter Mathias , Bernard Thomas , Moretti Sébastien , Stelling Joerg , Pagni Marco 
Published: January 2013

Abstract
Summary: MetaNetX.org is a website for accessing, analysing and manipulating genome-scale metabolic networks (GSMs) as well as biochemical pathways. It consistently integrates data from various public resources and makes the data accessible in a standardized format using a common namespace. Currently, it provides access to hundreds of GSMs and pathways that can be interactively compared (two or more), analysed (e.g. detection of dead-end metabolites and reactions, flux balance analysis or simulation of reaction and gene knockouts), manipulated and exported. Users can also upload their own metabolic models, choose to automatically map them into the common namespace and subsequently make use of the website’s functionality.
Availability and implementation: MetaNetX.org is available at http://metanetx.org.
Contact: help@metanetx.org
Interaction between Nitrous Oxide, Sevoflurane, and Opioids
Authors: Vereecke Hugo E. M. , Proost Johannes H. , Heyse Bjorn , Eleveld Douglas J. , Katoh Takasumi , Luginbühl Martin , Struys Michel M. R. F. 
Published: January 2013

Abstract

Background:
The interaction of sevoflurane and opioids can be described by response surface modeling using the hierarchical model. We expanded this for combined administration of sevoflurane, opioids, and 66 vol.% nitrous oxide (N2O), using historical data on the motor and hemodynamic responsiveness to incision, the minimal alveolar concentration, and minimal alveolar concentration to block autonomic reflexes to nociceptive stimuli, respectively.

Methods:
Four potential actions of 66 vol.% N2O were postulated: (1) N2O is equivalent to A ng/ml of fentanyl (additive); (2) N2O reduces C50 of fentanyl by factor B; (3) N2O is equivalent to X vol.% of sevoflurane (additive); (4) N2O reduces C50 of sevoflurane by factor Y. These four actions, and all combinations, were fitted on the data using NONMEM (version VI, Icon Development Solutions, Ellicott City, MD), assuming identical interaction parameters (A, B, X, Y) for movement and sympathetic responses.

Results:
Sixty-six volume percentage nitrous oxide evokes an additive effect corresponding to 0.27 ng/ml fentanyl (A) with an additive effect corresponding to 0.54 vol.% sevoflurane (X). Parameters B and Y did not improve the fit.

Conclusion:
The effect of nitrous oxide can be incorporated into the hierarchical interaction model with a simple extension. The model can be used to predict the probability of movement and sympathetic responses during sevoflurane anesthesia taking into account interactions with opioids and 66 vol.% N2O.
Policy for material efficiency—sustainable taxation as a departure from the throwaway society
Authors: Stahel Walter R 
Published: January 2013

The present economy is not sustainable with regard to its
per capita
material consumption. A dematerialization of the economy of industrialized countries can be achieved by a change in course, from an industrial economy built on throughput to a circular economy built on stock optimization, decoupling wealth and welfare from resource consumption while creating more work. The business models of a circular economy have been known since the mid-1970s and are now applied in a number of industrial sectors. This paper argues that a simple and convincing lever could accelerate the shift to a circular economy, and that this lever is the shift to a tax system based on the principles of sustainability: not taxing renewable resources including human labour—work—but taxing non-renewable resources instead is a powerful lever. Taxing materials and energies will promote low-carbon and low-resource solutions and a move towards a ‘circular’ regional economy as opposed to the ‘linear’ global economy requiring fuel-based transport for goods throughput. In addition to substantial improvements in material and energy efficiency, regional job creation and national greenhouse gas emission reductions, such a change will foster all activities based on ‘caring’, such as maintaining cultural heritage and natural wealth, health services, knowledge and know-how.
The energy required to produce materials: constraints on energy-intensity improvements, parameters of demand
Authors: Gutowski Timothy G. , Sahni Sahil , Allwood Julian M. , Ashby Michael F. , Worrell Ernst 
Published: January 2013

In this paper, we review the energy requirements to make materials on a global scale by focusing on the five construction materials that dominate energy used in material production: steel, cement, paper, plastics and aluminium. We then estimate the possibility of reducing absolute material production energy by half, while doubling production from the present to 2050. The goal therefore is a 75 per cent reduction in energy intensity. Four technology-based strategies are investigated, regardless of cost: (i) widespread application of best available technology (BAT), (ii) BAT to cutting-edge technologies, (iii) aggressive recycling and finally, and (iv) significant improvements in recycling technologies. Taken together, these aggressive strategies could produce impressive gains, of the order of a 50–56 per cent reduction in energy intensity, but this is still short of our goal of a 75 per cent reduction. Ultimately, we face fundamental thermodynamic as well as practical constraints on our ability to improve the energy intensity of material production. A strategy to reduce demand by providing material services with less material (called ‘material efficiency’) is outlined as an approach to solving this dilemma.
Laboratory seismic monitoring of supercritical CO2 flooding in sandstone cores using the Split Hopkinson Resonant Bar technique with concurrent x‐ray Computed Tomography imaging
Authors: Nakagawa Seiji , Kneafsey Timothy J. , Daley Thomas M. , Freifeld Barry M. , Rees Emily V. 
Published: January 2013

ABSTRACTAccurate estimation of CO2 saturation in a saline aquifer is essential for the monitoring of supercritical CO2 injected for geological sequestration. Because of strong contrasts in density and elastic properties between brine and CO2 at reservoir conditions, seismic methods are among the most commonly employed techniques for this purpose. However the relationship between seismic (P‐wave) velocity and CO2 saturation is not unique because the velocity depends on both wave frequency and the CO2 distribution in rock. In the laboratory, we conducted measurements of seismic properties of sandstones during supercritical CO2 injection. Seismic responses of small sandstone cores were measured at frequencies near 1 kHz, using a modified resonant bar technique (Split Hopkinson Resonant Bar method). Concurrently, saturation and distribution of supercritical CO2 in the rock cores were determined via x‐ray CT scans. Changes in the determined velocities generally agreed with the Gassmann model. However, both the velocity and attenuation of the extension wave (Young's modulus or ‘bar’ wave) for the same CO2 saturation exhibited differences between the CO2 injection test and the subsequent brine re‐injection test, which was consistent with the differences in the CO2 distribution within the cores. Also, a comparison to ultrasonic velocity measurements on a bedded reservoir rock sample revealed that both compressional and shear velocities (and moduli) were strongly dispersive when the rock was saturated with brine. Further, large decreases in the velocities of saturated samples indicated strong sensitivity of the rock's frame stiffness to pore fluid.