bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activating AMPK-p53 Axis Induced by Mitochondrial Impairment: A Novel Anti-Liver Cancer Mechanism of Sulfane Sulfur
Authors: Zheng Xue , Luo Yuhua , Huo Rui , Wang Yiwen , Chen Youbang , Chen Mianrong , Li Kexin , Zhao Qi , Zhang Hanyi , Li Xiaotong , Li Xiang , Zhang Hui , He Zaopeng , Huang Li , Yang Chuntao 
Published: August 2024

Abstract

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains refractory to conventional chemotherapy. Sulfane sulfur-based compounds have a long history in the treatment of HCC, but their efficacy has been disappointing. We recently reported a sulfane sulfur donor PSCP, which exhibits improved chemical stability and allows for greater structural modification. This study aimed to investigate the effects of PSCP on HCC and elucidate the underlying mechanisms. Bioinformatics algorithms, including clustering, function enrichment, feature screening, and survival analysis were employed to analyze the Cancer Proteome Atlas (CPTAC) proteomic data and The Cancer Genome Atlas (TCGA) transcriptomic sequencing data of HCC gene expression. The impact of PSCP on HCC were assessed both in vitro and in vivo. We evaluated the expression and activity of p53 and AMP-activated protein kinase (AMPK), as well as mitochondrial function. The molecular target of PSCP was identified using Autodock, and the binding interaction was visually analyzed. In HCC, sulfur metabolism was found to be reprogrammed and the downregulation of sulfur-related pathways was associated with poor patient prognosis. PSCP treatment inhibited HCC tumor growth in an allograft model, reduced cell viability and proliferation, but induced apoptosis. Moreover, PSCP promoted p53 expression and AMPK phosphorylation by inhibiting mitochondrial respiratory complex I. Collectively, our findings suggest that reprogramming of sulfur-related metabolic pathways is a key factor in HCC, and PSCP emerges as an effective therapeutic strategy, by activating the mitochondrial-AMPK-p53 signaling axis. KEYWORDS: Metabolic reprogramming; Hepatocellular carcinoma; Sulfane sulfur; Mitochondrial complex; AMPK; p53
Side Feeding Mechanism for Micro Cathode Arc Thruster
Authors: Duppada Guru Sankar , Taploo Anmol , Soni Vikas , Karp Adam , Spinelli Jake , Keidar Michael 
Published: August 2024

Abstract

The primary focus of this work is to characterize a micro-cathode arc thruster with a propellant feeding mechanism to extend its lifetime. To that end, we have proposed a side-feeding micro-cathode arc thruster. The thruster’s in-built feeding mechanism allows the cathode to be consumed during operation, providing a continuous supply of propellant. The ion-to-arc current fraction of about 0.025 was detected and an initial pulse count of 1.34M was achieved, demonstrating the effectiveness of the feeding mechanism. An average erosion rate of 4 µg/C was measured and a total change in cathode length of 10 mm indicates the successful implementation of the spring-loaded side feeding mechanism.
Evaluating Sustainable Performance in China’s Banking Sector Using CPT-TOPSIS
Authors: Chao Lu 
Published: August 2024

Abstract

The sustainable development of financial institutions has increasingly captured the attention of both industry stakeholders and investors. This study introduces a novel decision-making framework that integrates Cumulative Prospect Theory (CPT) with the traditional TOPSIS model to evaluate the sustainability performance of commercial banks. Drawing on previous research, we developed a multi-criteria framework that includes five key dimensions—economic, social, environmental, governance, and financial—along with 15 associated indicators. This model was applied to conduct a comprehensive evaluation of five major Chinese commercial banks. Empirical results indicate that our model offers significant advantages over the entropy-weighted TOPSIS model, particularly in uncertain environments. The primary contribution of this study lies in the innovative application of Cumulative Prospect Theory to the sustainability assessment of Chinese commercial banks, coupled with the integration of 15 indicators based on the Global Reporting Initiative (GRI) framework. This approach provides fresh theoretical insights and practical tools for advancing banking performance and sustainability research. Our model bridges the gap between the sustainability assessment practices of large Chinese commercial banks and international standards, offering a promising tool for the analysis and enhancement of bank sustainability strategies.
Ultrafast Laser Asynchronous Processing for Laser Metal Deposition Manufacturing of Ti6Al4V
Authors: Song Yuyang , Zhou Jing 
Published: August 2024

Abstract

Additive manufacturing technology has rapidly developed to enable the manufacturing of various complex feature parts. However, parts manufactured through Laser Metal Deposition (LMD) often exhibit poor surface quality with the waviness of significant peak-to-valley distances, making it hard to improve surface quality through laser polishing. This study proposes a surface treatment method using ultrafast laser asynchronous processing to solve the issue of large waviness in Ti6Al4V parts manufactured by LMD, in which rough processing is carried out using picosecond laser with a galvanometer and precision processing is conducted using femtosecond laser with an objective lens. The influence of laser energy, defocus distance, and repetition times on material surface quality is investigated. Using the proper processing parameters, the initial surface with a step of 250 µm can be eliminated, which demonstrates the feasibility of ultrafast laser asynchronous processing in reducing peak-to-valley distance in materials.
Electrodeposited MoS2 nanostructured thin film: surface structural probing and photoelectrochemical characterization
Authors: Ajayeoba Yetunde A. , Adewinbi Saheed A. , Akinrinola Olusola , Olusola Olajide Ibukun-Olu , Akande Akinlolu , Awodugba Ayodeji O. 
Published: August 2024

Abstract

Molybdenum disulfide (MoS2) has advantageous traits and characteristics that make it suitable for a diverse array of practical applications, such as optoelectronics and gas sensing. Enhancing the surface area of the adsorbent leads to a proportional increase in its performance. Hence, the synthesized two-electrode electrodeposited MoS2 (ED-MoS2) thin films were microstructurally characterized to investigate its surface modulation for suitable enhancement in its applicative properties. The characterization shows that the surface properties of the deposited film can easily be modulated to favor its needs and can be done by simply varying its electrodeposition parameters, such as growth period and voltage supplied. In addition, persistent n-type conductivity of intrinsic MoS2 makes it challenging to achieve p-type conductivity. By simply varying the cathodic potential, the challenge of obtaining p-type MoS2 thin films was solved. The photoelectrochemical cell measurements revealed that lower cathodic potentials (1.15 V – 1.35 V) favored the growth of p-type MoS2 layers while the growth of n-type MoS layers was achieved at the higher cathodic potential.
Field study on the dynamic characteristics of sewage collection in a circular aquaculture tank
Authors: Wu Yanfei , Gui Fukun , Yang Jianxin , Qi Hongfang , Zhang Hong , Wang Yang , Feng Dejun , Zhang Qingjing 
Published: August 2024

Abstract

To solve the problem of low performance in sewage collection of the circular aquaculture tank, this paper systematically studies the influence of flow rate Q of the jet pipe, the deployment distance ratio d/r (d is the distance between the midpoint of the axis and the nearest tank wall, and r is the radius of the circular aquaculture tank), the deployment angle θ, and the structure of the jet pipe on the dynamic characteristics of sewage collection. In the field study, a high-definition camera was used to record the distribution of sewage, the distribution of the flow field in the aquaculture tank was measured by the Acoustic Doppler Velocimetry. Thus, the distance between the sewage and the center of the tank was quantified. Meanwhile, the sewage collection performance of the aquaculture tank was evaluated by comparing the maximum distance between the sewage and the center of the tank under different working conditions. The results indicated that the formation of an effective horizontal circulation in the circular aquaculture tank is the primary condition for sewage accumulation to the center of the tank, and different flow rate Q of the jet pipe, the deployment distance ratio d/r, the deployment angle θ, and the structure of the jet pipe all can affect the sewage collection effect in the tank. In the horizontal single-pipe single-hole jet pipe structure mode, the best sewage collection result was obtained at the deployment angle θ of 0°, the deployment distance ratio of 1/4, and the deployment flow rate Q of 7 L/s; when the deployment flow rate Q was less than 7 L/s, the sewage accumulated near the tank wall, and the sewage particle dispersion was relatively high. In the vertical single-pipe porous jet pipe structure mode, better sewage collection performance was obtained when the deployment flow Q was adjusted to 7 ~ 9 L/s, the deployment angle θ was set to 45°, and the deployment distance ratio d/r was set to 1/4. The sewage collection performance of the aquaculture tank under the vertical single-pipe porous jet pipe deployment mode was obviously better than that of the horizontal single-pipe single-hole jet pipe mode. The results can directly and effectively guide the inlet design of such kind aquaculture tanks to reduce the flow rate and energy consumption and improve sewage collection performance.
Factors Influencing Pediatric COVID-19 Vaccination Uptake: A Quantitative Investigation in the Philippines
Authors: Lota Maria Margarita , Acacio-Claro Paulyn Jean , Vogt Florian , Roxas Evalyn , Abeleda Alvin , Dalisay Soledad Natalia , Landicho Madilene , Fujimori Yoshiki , Rosuello Jan Zarlyn , Kaufman Jessica , Danchin Margaret , Belizario Vicente 
Published: August 2024

Abstract

Background: COVID-19 vaccines were recommended for the pediatric population after adults due to both the direct and indirect effects of COVID-19. Despite ongoing vaccination efforts in the Philippines, pediatric COVID-19 vaccination uptake remains low. As such, this study aimed to determine the enablers and barriers of pediatric COVID-19 vaccination uptake amongst children 5-11 years in the Philippines.
Methods: A cross-sectional survey among 546 caregivers of children aged 5-11 years was conducted onsite in three selected regions in the Philippines with low COVID-19 vaccine coverage between July and October 2023. Multivariable logistic regression was performed to identify factors associated with pediatric COVID-19 vaccination uptake.
Results: The most common reasons for vaccination of children were protection against COVID-19 (93.7%), influence of government mandated regulations including restrictions to school, travel, and social activities (48.3%), and recommendation of healthcare workers (19.6%). High vaccine confidence (79%), high perceived vaccine benefit (81.1%) and need for vaccination (78.3%) were enablers of vaccination. Among those who did not vaccinate their children, the most common reasons were distrust in vaccine safety or fear of side effects (58.5%), perception that the child was too young (25.3%), and the child not wanting to get vaccinated (18.2%). Caregivers who decided not to vaccinate their child also had concerns about side effects (35.7%), low perceived need for COVID-19 vaccination (21.5%) and disagreed at requiring vaccinations for schooling (26.3%). Younger caregiver age [aOR=3.00; 95% CI 1.65-5.46 for adults 30-45 years vs aOR=2.65; 95% CI 1.17-5.5.99 for adults 46-59 years], and perceived need for vaccination (OR=2.56; 95% CI 1.31-5.03) were enabling factors of pediatric COVID-19 vaccination uptake in the multivariable analysis.
Conclusions: Key factors associated with COVID-19 pediatric vaccination uptake in the Philippines were perceived protection against disease, government mandated regulations and healthcare worker recommendations, while non-vaccination was associated with safety concerns, and children’s age and preference to not be vaccinated. Understanding the social and behavioral drivers among caregivers may help policy decision-makers and implementers develop targeted interventions to enhance uptake of COVID-19 and routine childhood vaccines.
Efficient Group Authentication with Multiple Authentications on Resource-Limited Devices
Authors: Yuan Jiangtao , Wang Chenyu , Yang Jing , Zhou Shijie 
Published: August 2024

Abstract

In the era of the Internet of Everything, the Internet of Things (IoT) has become an integral part of people’s lives. Identity authentication faces significant challenges when dealing with various devices. Traditional one-to-one authentication methods struggle to meet the requirements of massive connected devices and do not account for the resource limitations of these devices. Group authentication (GA) in many-to-many authentication methods can effectively address the issues of large-scale authentication. Since Harn [1] proposed the group authentication scheme (GAS), extensive research has been conducted on GA. In GAS, the authentication of different users is conducted simultaneously rather than individually. Harn’s GAS [1] is based on Shamir’s threshold scheme, which has low computational resource requirements. Therefore, GA can be applied to resource-constrained IoT devices. While ensuring computational efficiency, security remains a significant challenge for current GA methods. However, many existing schemes cannot provide security guarantees for widespread use. In this paper, an asynchronous group authentication protocol based on bivari-ate symmetric polynomials and discrete logarithm problem are proposed. The method uses bivariate symmetric polynomials to generate tokens for group members. These tokens enable users to generate random values, which are then used to update the original tokens. This ensures that each user can protect the product of the Lagrange component and a generator of a cyclic group. The proposed scheme in this paper offer enhanced security.
The association between Ambient Temperature and Influenza Activity across 124 countries globally during 2014–2019
Authors: Cao Xiaoxiao , Luo Zhenghan , Zhu Wenhao , He Ran , Li Yihao , Hui Shirong , Yang Sheng , Yu Rongbin , Huang Peng 
Published: August 2024

Abstract

Background: The results of the association between ambient temperature and influenza in previous studies have been inconsistent in different regions. And global, multi-regional studies are lacking.
Methods: Our study used two stages of analysis to further evaluate the association between ambient temperature and influenza activity at regional and global scales. Meteorological data and influenza data were collected in 124 countries during 2014–2019. The country-specific associations between weekly mean temperature and the risk of all types of influenza (Flu-All)), influenza A (Flu-A), and influenza B (Flu-B) were estimated by using a distributed lag non-linear model (DLNM), and the pooled regional and global effects by using multilevel meta-analysis. Climate zones and influenza transmission zones performed stratified analyses.
Results: There was a non-linear curve relating ambient temperature to influenza risk in 124 countries. Within the optimal lag of 2 weeks, a bimodal (M-shaped) relationship was observed between temperature and influenza risk, with two risk peaks at -8°C with two RR of 6.02 (95% CI: 1.92-20.77) and of 3.76 (95% CI: 2.39-5.91), and at 22°C with two RR of 3.08 (95% CI: 1.27-7.49) and 2.08 (95% CI: 1.55-2.80). For Flu-B, it was N-shaped, peaking at 1°C with an RR of 4.48 (95%CI: 1.74-11.55). Risk curves fitted under geographic location-induced influenza transmission pattern zones showed a more characteristic shape than risk curves fitted under climatic zones.
Conclusions: Globally, low temperatures significantly increased the risk of influenza, and Flu-A activity dominated throughout the year with two peaks. Geographic homogeneity was relatively dominant concerning the cumulative association of influenza activity with temperature. The findings have important implications for the development of strategies to control global and regional influenza and respond to climate change.
A Novel Integrated Fault Diagnosis Method Based on Digital Twin
Authors: Hu XiangRui , Liu Linglin , Quan Zhengyu , Huang Jinguo , Liu Jing 
Published: August 2024

Abstract

Fault diagnosis plays a crucial role in the actual production activities of enterprises. In recent years, with the development and popularization of Internet of Things (IoT) technology, the efficient acquisition and storage of actual production data have become possible, enabling data-driven methods based on deep learning to achieve remarkable results in the field of fault diagnosis. However, existing technologies still have issues, such as less consideration of the temporal information of fault occurrences and the imbalance between normal and fault data in production activities, which can affect the performance of fault diagnosis. To address these problems, this paper proposes a novel integrated fault diagnosis method, comprehensively considering data balance, feature extraction, and temporal information at the time of fault occurrence.This method is established based on two key processes: the creation of a dataset using Digital Twin technology and the development of an integrated fault diagnosis model (CNN-BLSTM-Attention). The virtual production data generated under various operating conditions through Digital Twin technology provide us with a rich set of sample data. The integrated fault diagnosis model processes the input data using a sliding window to consolidate feature and temporal information, enabling precise fault diagnosis. This paper addresses the issue of small sample fault diagnosis for screw press faults and validates the effectiveness of the proposed method in practical applications. Experimental results demonstrate that, compared to existing fault diagnosis methods, the proposed method reduces noise sensitivity and significantly improves fault diagnosis accuracy, highlighting its superiority.
Role of life-history strategies of arbuscular mycorrhizal fungi in partner selection by a juvenile C4 grass under low-light conditions
Authors: Cahyaningtyas Anjar , Ezawa Tatsuhiro 
Published: August 2024

Abstract

Background and Aims
In coastal grasslands carbon cost of arbuscular mycorrhizal (AM) fungi is a crucial factor for the successful establishment of juvenile plants grown under the canopy of large plants that restricts their photosynthesis. Network competitor (NC) fungi that colonize via hyphal networks may be less costlythan soil-propagule-mediated colonizer (SP) fungibecause C cost for colonization could be covered by the donor plant of the networks.
Methods
Intact root-soil-core samples (NC inocula) and root-zone-soil samples (sieved before inoculation, SP inocula) were collected from a coastal grassland, and seedlings of Miscanthus sinensis were grown with both inocula and either with the NC or SP inocula with or without shading. DNA was extracted from the root, and fungal LSU rDNA was amplified and sequenced to assign to AM fungal operational taxonomic units (OTUs). All AM fungi that occurred with the SP inocula were defined as SP fungi, whereas those that occurred uniquely with the NC inocula were defined as NC fungi.
Results
Shading increased the genus richness of SP fungi, but not that of NC fungi, without changing OTU richness, which was due to the replacement of several Glomerales SP fungi with those that belong to diverse genera in non-Glomerales under the shaded conditions.
Conclusion
These observations suggest that cost of SP fungi is comparable to that of NC fungi and, further, that Glomerales fungi are generally less competitive under which photosynthesis of the host is restricted, providing new insight into the selection of AM fungal partners by plants.
Temperature-induced changes in the hematological and biochemical parameters of Nile tilapia anesthetized with Ocimum basilicum
Authors: Santos Paola Capistrano , Lopes Emilly Monteiro , Ventura Arlene Sobrinho , Cardoso Claudia Andrea Lima , Silva Alexandre Vaz , Costa Domickson Silva , Tedesco Marília , Jerônimo Gabriela Tomas , Martins Maurício Laterça 
Published: August 2024

Abstract

The study aimed to evaluate the effect of temperatures of 23 and 27 ºC on the hematology of Nile tilapia juveniles (Oreochromis niloticus) subjected to anesthesia using the essential oil of basil (Ocimum basilicum) at a concentration of 250 mg L-1. A total of 112 fish were divided into 4 treatments and distributed as follows: fish anesthetized with 250 mg L-1 at a temperature of 23ºC (n=42); fish anesthetized with 250 mg L-1 at a temperature of 27ºC (n=42); and for each temperature, a control group fish exposed to diluent solution (95% ethanol) (n=14, seven per temperature); a control group fish (water) (n=14, seven per temperature). They were exposed to 10 min for both temperatures. Blood collection was performed after the anesthetic induction at each temperature to determine the hematocrit, hemoglobin concentration (Hb), red blood cell count (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), relative values of leukocytes and absolute values of leukocytes and thrombocytes, in addition to evaluating plasma chloride and total calcium ions. The analysis of chemical composition by gas chromatography coupled with mass spectrometry (GC-MS) demonstrated methyl chavicol (70.04%) and linalool (24.59%) as the major components of basil essential oil. Fish anesthetized at a temperature of 23 ºC showed lower neutrophil counts (p<0.05) compared to the other tested groups. For the temperature of 27 ºC, values of MCV, MCHC, and RBC values decreased (p<0.05) following exposure to basil essential oil. The calcium ion showed a statistical difference (p<0.05) between the treatments about the water control group. It is concluded that basil essential oil presented a positive anesthetic effect. The use of O. basilicum essential oil as an anesthetic in Nile tilapia was the best at 23ºC, causing less hematological and biochemical stress.