bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hurricane Sandy before 1900 and after 2100
Authors: Lackmann Gary M. 
Published: September 2014

Abstract
To what extent did large-scale thermodynamic climate change contribute to the intensity and unusual track of Hurricane Sandy, which affected the U.S. mid-Atlantic region in late October 2012? How much of an impact would projected future climate change have on a storm such as Sandy? These questions are investigated using an ensemble of high-resolution numerical simulations in conjunction with analyzed and projected changes from a suite of general circulation models (GCMs). Simulations initialized with current analyses from the midpoint of Sandy’s life cycle, while the system was centered near the Bahamas, adequately replicate the observed intensity and track of Sandy. Initial and boundary condition data are then altered with thermodynamic change fields obtained from a five-member GCM ensemble, allowing hypothetical replication of the synoptic weather pattern that accompanied Hurricane Sandy, but for large-scale thermodynamic conditions corresponding to the 1880s and for projections to the twenty-second century. The past ensemble produces a slightly weaker storm that makes landfall south of the observed location. The future ensemble depicts a significantly more intense system that makes landfall farther north, near Long Island, New York. Within the limitations of the methods used, it is suggested that climate change to date exerted only a modest influence on the intensity and track of Sandy. The strengthening in the simulations run with projected future warming is consistent with increased condensational heating; changes in the synoptic steering flow also appear to result from diabatic processes. The questions of how climate change affected Sandy’s genesis and early life cycle, changes in the frequency of this type of synoptic pattern, and changes in impacts related to coastal development and sea level rise are not considered here.
Development and Evaluation of Statistical Downscaling Models for Monthly Precipitation
Authors: Goly Aneesh , Teegavarapu Ramesh S. V. , Mondal Arpita 
Published: September 2014

Abstract
Several statistical downscaling models have been developed in the past couple of decades to assess the hydrologic impacts of climate change by projecting the station-scale hydrological variables from large-scale atmospheric variables simulated by general circulation models (GCMs). This paper presents and compares different statistical downscaling models that use multiple linear regression (MLR), positive coefficient regression (PCR), stepwise regression (SR), and support vector machine (SVM) techniques for estimating monthly rainfall amounts in the state of Florida. Mean sea level pressure, air temperature, geopotential height, specific humidity, U wind, and V wind are used as the explanatory variables/predictors in the downscaling models. Data for these variables are obtained from the National Centers for Environmental Prediction–National Center for Atmospheric Research (NCEP–NCAR) reanalysis dataset and the Canadian Centre for Climate Modelling and Analysis (CCCma) Coupled Global Climate Model, version 3 (CGCM3) GCM simulations. The principal component analysis (PCA) and fuzzy c-means clustering method (FCM) are used as part of downscaling model to reduce the dimensionality of the dataset and identify the clusters in the data, respectively. Evaluation of the performances of the models using different error and statistical measures indicates that the SVM-based model performed better than all the other models in reproducing most monthly rainfall statistics at 18 sites. Output from the third-generation CGCM3 GCM for the A1B scenario was used for future projections. For the projection period 2001–10, MLR was used to relate variables at the GCM and NCEP grid scales. Use of MLR in linking the predictor variables at the GCM and NCEP grid scales yielded better reproduction of monthly rainfall statistics at most of the stations (12 out of 18) compared to those by spatial interpolation technique used in earlier studies.
Effects of Tunable Data Compression on Geophysical Products Retrieved from Surface Radar Observations with Applications to Spaceborne Meteorological Radars
Authors: Gabriel Philip M. , Yeh Penshu , Tsay Si-Chee 
Published: September 2014

AbstractThis paper presents results and analyses of applying an international space data compression standard to weather radar measurements that can easily span eight orders of magnitude and typically require a large storage capacity as well as significant bandwidth for transmission. By varying the degree of the data compression, the nonlinear response of models that relates measured radar reflectivity and/or Doppler spectra to the moments and properties of the particle size distribution characterizing clouds and precipitation was analyzed. Preliminary results for the meteorologically important phenomena of clouds and light rain indicate that for a ±0.5-dB calibration uncertainty, typical for the ground-based pulsed-Doppler 94-GHz (or 3.2 mm, W band) weather radar used as a proxy for spaceborne radar in this study, a lossless compression ratio of only 1.2 is achievable. However, further analyses of the nonlinear response of various models of rainfall rate, liquid water content, and median volume diameter show that a lossy data compression ratio exceeding 15 is realizable. The exploratory analyses presented are relevant to future satellite missions, where the transmission bandwidth is premium and storage requirements of vast volumes of data are potentially problematic.
Dynamical Prediction of the Early Season Rainfall over Southern China by the NCEP Climate Forecast System
Authors: Zhao Siyu , Yang Song 
Published: September 2014

Abstract
The early season rainfall (ESR) over southern China, usually occurring from April to June, is a prominent meteorological phenomenon of the East Asian monsoon system. In this paper, output from the 45-day hindcast by the NCEP Climate Forecast System, version 2 (CFSv2), and various observational datasets are analyzed to assess the predictability of the ESR and associated atmospheric circulation. Results show that CFSv2 can successfully predict the ESR and associated circulation patterns over southern China. The lower-tropospheric convergence and upper-tropospheric divergence as well as the local upward motion over southern China lead to the formation of ESR. Analysis of bias shows small differences and close relationships between the predicted and observed ESR values when the forecast lead time is less than 2 weeks. The skill in the ESR predictions by CFSv2 decreases significantly when the lead time is longer than 2 weeks. Overall, CFSv2 has a higher level of skill when predicting the southern China ESR compared to the rainfall over other Asian regions during the same period of time.
Evaluation with 3.0-T MR imaging: predicting the pathological response of triple-negative breast cancer treated with anthracycline and taxane neoadjuvant chemotherapy
Authors: Kim Min Jung , Kim Eun-Kyung , Park Seho , Moon Hee Jung , Kim Seung , Park Byeong-Woo 
Published: September 2014

Background Triple-negative breast cancer (TNBC) which expresses neither hormonal receptors nor HER-2 is associated with poor prognosis and shorter survival. Several studies have suggested that TNBC patients attaining pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) show a longer survival than those without pCR. Purpose To assess the accuracy of 3.0-T breast magnetic resonance imaging (MRI) in predicting pCR and to evaluate the clinicoradiologic factors affecting the diagnostic accuracy of 3.0-T breast MRI in TNBC patients treated with anthracycline and taxane (ACD). Material and Methods This retrospective study was approved by the institutional review board; patient consent was not required. Between 2009 and 2012, 35 TNBC patients with 3.0-T breast MRI prior to ( n = 26) or after ( n = 35) NAC were included. MRI findings were reviewed according to pCR to chemotherapy. The diagnostic accuracy of 3.0-T breast MRI for predicting pCR and the clinicoradiological factors affecting MRI accuracy and response to NAC were analyzed. Results 3.0-T MRI following NAC with ACD accurately predicted pCR in 91.4% of TNBC patients. The residual tumor size between pathology and 3.0-T MRI in non-pCR cases showed a higher correlation in the Ki-67-positive TNBC group ( r = 0.947) than in the Ki-67 negative group ( r = 0.375) with statistical trends ( P = 0.069). Pre-treatment MRI in the non-pCR group compared to the pCR group showed a larger tumor size ( P = 0.030) and non-mass presentation ( P = 0.015). Conclusion 3.0-T MRI in TNBC patients following NAC with ACD showed a high accuracy for predicting pCR to NAC. Ki-67 can affect the diagnostic accuracy of 3.0-T MRI for pCR to NAC with ACD in TNBC patients.
Medium-term effectiveness of online behavioral training in migraine self-management: A randomized trial controlled over 10 months
Authors: Sorbi MJ , Kleiboer AM , van Silfhout HG , Vink G , Passchier J 
Published: September 2014

Aim This randomized, controlled trial examined the medium-term effectiveness of online behavioral training in migraine self-management (oBT; N = 195) versus waitlist control (WLC; N = 173) on attack frequency, indicators of self-management (primary outcomes), headache top intensity, use of rescue medications, quality of life and disability (secondary outcomes). Methods An online headache diary following the ICHD-II and questionnaires were completed at baseline (T0), post-training (T1) and six months later (T2). Missing data (T1: 24%; T2: 37%) were handled by multiple imputation. We established effect sizes (ES) and tested between-group differences over time with linear mixed modelling techniques based on the intention-to-treat principle. Results At T2, attack frequency had improved significantly in oBT (−23%, ES = 0.66) but also in WLC (−19%; ES = 0.52). Self-efficacy, internal and external control in migraine management – and triptan use – improved only in oBT, however. This indicates different processes in both groups and could signify (the start of) active self-management in oBT. Also, only oBT improved migraine-specific quality of life to a sizable extent. Conclusions oBT produced self-management gains but could not account for improved attack frequency, because WLC improved as well. The perspective that BT effects develop gradually, and that online delivery will boost BT outreach, justifies further research.
Financial Deepening and Economic Growth in Saudi Arabia
Authors: Marashdeh Hazem A. , Al-Malkawi Husam-Aldin N. 
Published: September 2014

This article draws on the authors’ previously published work. It aims to examine the relationship between financial deepening and economic growth in one of the major emerging economies, namely Saudi Arabia. Using time series data from 1970 to 2010, the study employs the autoregressive distributed lag approach to co-integration. The financial depth or size of the financial intermediaries’ sector is measured by the monetisation ratio (M2/GDP). On the one hand, the results show a positive and statistically significant long-run relationship between financial deepening, as measured by M2/GDP, and economic growth, as measured by gross domestic product (GDP) per capita growth. On the other hand, there is no evidence of the short-run dynamic bidirectional relationship between the variables. By and large, the result supports the supply-leading hypothesis that financial deepening spurs economic growth in the case of Saudi Arabia. JEL Classification: G20, O40, C22
Durational variability of schwa in early and late Spanish–English bilinguals
Authors: Byers Emily , Yavaş Mehmet 
Published: September 2014

Aims: The purpose of this study was to evaluate whether bilinguals categorically displayed shorter or longer schwa durations between fixed word pairs where one word contains a deletable syllable and the other does not (as in “rational” [ræʃənəl] → [ræʃnəl] compared with “rationality” [ræʃənæləti]). We hypothesized that monolingual and early bilingual speakers would produce shorter values for “deletable” schwas whereas late bilinguals would not. Methodology: Twenty native English speakers and 40 Miami-based Spanish–English bilinguals (20 early and 20 late bilinguals) were asked to read sentences containing target words from 10 semantically related word pairs. Analysis: A three-way mixed model ANOVA was performed to determine the relationship between schwa duration and the following factors: language group, word root, and deletable/non-deletable category. Pairwise t-tests were also performed on individual categories to determine if semantically related pairs differed in duration. Conclusions: Results indicated that native English speakers produce significantly shorter durations for schwa in deletable versus non-deletable position. Early bilingual productions are very similar to those of English-only speakers, whereas late bilinguals display much longer durations in both categories. Originality: This study is the first to directly compare word-internal vowel duration patterns in Spanish–English bilingual speakers. Implications: These results indicate that age of L2 acquisition is a predictive factor in determining how native-like an L2 speaker’s pronunciation of reduced vowels will be. Limitations: Given the specific nature of the word pairs tested, a reading instrument was the most efficient manner of eliciting target word pairs. Future studies should try to evaluate this issue using other types of stimuli.
On the meaning of life: A qualitative interpretive meta synthesis of the lived experience of life without parole
Authors: Sliva Shannon M 
Published: September 2014

Summary This Qualitative Interpretive Meta Synthesis (QIMS) develops a more complete understanding of the lived experience of serving a Life Without Parole (LWOP) sentence by synthesizing the results of existing qualitative studies focused on this population. The four studies selected for this QIMS contain interviews with 86 male prisoners serving a sentence of LWOP. The current synthesis uses phenomenology and grounded theory as methods to obtain a new understanding from the limited data on this specialized vulnerable population. Findings The conceptual model emerging from this QIMS indicates that prisoners experience the sentence of LWOP with feelings of deep loss which mimic the grief response of the dying patient as described by Kubler-Ross (1969). Upon the initial shock of sentencing and imprisonment, inmates pass through stages of denial, anger, bargaining, depression, and ultimately, acceptance. In order to cope with the harsh reality of life imprisonment, ‘lifers’ find ways to exercise personal choice, keep a positive outlook, and forge meaning from their sufferings. Those who are successful in these tasks discover great resilience. Applications This synthesis suggests that the application of grief and resilience theories may be relevant with prisoners and other similarly marginalized populations coping with extraordinary loss of self. Given the potential of inmates in this study to discover personal resilience and engage in attempts at social reconciliation, policy makers should consider whether a sentence of LWOP shortchanges both inmates and society.
Using the Venom of a Snake for an Antidote: exploring strategies and services for sex workers in preparation for the World Cup 2014
Authors: Ewen Janine Elizabeth 
Published: September 2014

Aims: This article considers the public health implications that were predicted by sex workers a year prior to the FIFA World Cup 2014, with considerations towards the Olympic Games in 2016. Primary research conducted in 2013 in Brazil’s second largest city, Rio de Janeiro, gave sex workers and civil society organizations the opportunity to voice concerns of the everyday disadvantages faced by those involved in the sex industry, with emphasis on what could cause further detriments from acting as a double draw international sporting host. This research largely took place through invitation at the 2013 Rio State Conference on HIV/AIDS, Equality and Human Rights. Methods: Mixed methods research – pre-arrival questionnaires and interviews led by a semi-structured interview guide – was deemed suitable for the primary research collection. The use of the research software NVivo allowed data to be categorised into key themes to form the basis of this research article. Working with a Portuguese translator, case studies of transsexual sex workers and civil society organizations were developed. Results: Police violence was the main re-occurring theme expressed as a continued fear, alongside the added increase of security measures that the games would bring, to reduce organized crime, and through the Pacification programme. The majority of sex workers and organizations believed that there was no support from the Brazilian government to continue to provide services of high demand, including social care and legal assistance. Sex workers also felt prejudice in receiving HIV/AIDS treatment from government-led health services. A desirable outcome for the sex worker community would be for the government to consider the following: recommendations devised for further health and well being support; an act or law of non-violence against them; and recommendations to decimalize the sex industry. Conclusions: The Brazilian government has received global recognition for its response to the HIV/AIDS epidemic, however the treatment based and contraception promotion does not extend itself to consider the social implications that put sex workers at huge public health risks, especially physical violence. This research provides an important case for explicit revisions of policies in Brazil regarding the health and safety of sex workers.
A novel role for ezrin in breast cancer angio/lymphangiogenesis
Authors: Ghaffari Abdi , Hoskin Victoria , Szeto Alvin , Hum Maaike , Liaghati Navid , Nakatsu Kanji , Madarnas Yolanda , Sengupta Sandip , Elliott Bruce E 
Published: September 2014

Abstract
Introduction
Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced lymphangiogenesis remain poorly understood. The expression of ezrin, a membrane cytoskeletal crosslinker and Src substrate, correlates with poor outcome in a diversity of cancers including breast. Furthermore, ezrin is essential in experimental invasion and metastasis models of breast cancer. Ezrin acts cooperatively with Src in the regulation of the Src-induced malignant phenotype and metastasis. However, it remains unclear if ezrin plays a role in Src-induced tumour angio/lymphangiogenesis.

Methods
The effects of ezrin knockdown and mutation on angio/lymphangiogenic potential of human MDA-MB-231 and mouse AC2M2 mammary carcinoma cell lines were examined in the presence of constitutively active or wild-type (WT) Src. In vitro assays using primary human lymphatic endothelial cells (hLEC), an ex vivo aortic ring assay, and in vivo tumour engraftment were utilized to assess angio/lymphangiogenic activity of cancer cells.

Results
Ezrin-deficient cells expressing activated Src displayed significant reduction in endothelial cell branching in the aortic ring assay in addition to reduced hLEC migration, tube formation, and permeability compared to the controls. Intravital imaging and microvessel density (MVD) analysis of tumour xenografts revealed significant reductions in tumour-induced angio/lymphangiogenesis in ezrin-deficient cells when compared to the WT or activated Src-expressing cells. Moreover, syngeneic tumours derived from ezrin-deficient or Y477F ezrin-expressing (non-phosphorylatable by Src) AC2M2 cells further confirmed the xenograft results. Immunoblotting analysis provided a link between ezrin expression and a key angio/lymphangiogenesis signaling pathway by revealing that ezrin regulates Stat3 activation, VEGF-A/-C and IL-6 expression in breast cancer cell lines. Furthermore, high expression of ezrin in human breast tumours significantly correlated with elevated Src expression and the presence of lymphovascular invasion.

Conclusions
The results describe a novel function for ezrin in the regulation of tumour-induced angio/lymphangiogenesis promoted by Src in breast cancer. The combination of Src/ezrin might prove to be a beneficial prognostic/predictive biomarker for early-stage metastatic breast cancer.
Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors
Authors: Hefnawy Mohammed M , Homoda Atef M , Abounassif Mohammed A , Alanazi Amer M , Al-Majed Abdulrahaman , Mostafa Gamal A 
Published: September 2014

Abstract

Background
The construction and electrochemical response characteristics of Poly (vinyl chloride) membrane sensors for moxifloxacin HCl (MOX) are described. The sensing membranes incorporate ion association complexes of moxifloxacin cation and sodium tetraphenyl borate (NaTPB) (sensor 1), phosphomolybdic acid (PMA) (sensor 2) or phosphotungstic acid (PTA) (sensor 3) as electroactive materials.

Results
The sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 × 10-2 - 4.0 × 10-6, 1 × 10-2 - 5.0 × 10-6, 1 × 10-2 - 5.0 × 10-6 M), with detection limits of 3 × 10-6, 4 × 10-6 and 4.0 × 10-6 M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 μg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6% and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively.

Conclusions
The proposed sensors have been applied for direct determination of moxifloxacin in some pharmaceutical preparations. The results obtained by determination of moxifloxacin in tablets using the proposed sensors are comparable favorably with those obtained using the US Pharmacopeia method. The sensors have been used as indicator electrodes for potentiometric titration of moxifloxacin.
French History and the Transnational Turn
Authors: Green Nancy L. 
Published: September 2014

How do you do the history of a place—by doing in-depth research into its political, economic, social and/or cultural ways and manners, or by expanding the breadth to take into account external, interactive factors? The debate is an ongoing epistemological one that turns around questions of scale and scope: small versus large research topics, micro versus macro approaches, and, more recently, the local versus the global. This article explores three propositions: (1) French history is properly studied as... French history, in all of its medieval, revolutionary, industrial, and/or contemporary specificity; (2) French history can only be properly studied as global history; (3) the study of French history has already confronted the transnational and will continue to do so.
Comment écrire l’histoire d’un lieu : à partir d’une connaissance profonde de ses mœurs et ses pratiques, de son histoire politique, économique, sociale, ou culturelle ; ou bien à travers une large contextualisation qui incorpore des éléments externes et interactifs ? Le débat entre aires culturelles et approches disciplinaires se greffe sur les questions d’échelle et de l’étendue du champ, entre projets vastes et projets plus circonscrits dans l’espace, entre approches macro et micro, et, plus récemment, entre recherches mettant l’accent sur le global ou le local. Cet article explore trois propositions : (1) l’histoire française doit être étudiée dans sa spécificité ; (2) l’histoire française ne peut être étudiée qu’à partir d’une insertion dans une histoire globale ; (3) l’historiographie s’est déjà confrontée avec des sujets transnationaux, et cette approche continuera à irriguer le champ.