bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining Global Benchmarks for Laparoscopic Right Posterior Sectionectomy/H67
Authors: Zhao Jianping , Lu Yuanxiang , Zhang Wanguang , Chua Darren W. , Liu Qu , Liu Rong , Pratschke Johann , Ratti Francesca , Zimmitti Giuseppe , Aghayan Davit L. , Edwin Bjørn , Siow Tiing-Foong , Scatton Olivier , Herman Paulo , Marino Marco V. , Mazzaferro Vincenzo , Chiow Adrian K. H. , Sucandy Iswanto , Ivanecz Arpad , Choi Sung Hoon , Lee Jae Hoon , Gastaca Mikel , Vivarelli Marco , Giuliante Felice , Ruzzenente Andrea , Yong Chee-Chien , Yin Mengqiu , Fondevila Constantino , Efanov Mikhail , Morise Zenichi , Di Benedetto Fabrizio , Brustia Raffaele , Dalla Valle Raffaele , Boggi Ugo , Geller David , Belli Andrea , Memeo Riccardo , Mejia Alejandro , Park James O. , Rotellar Fernando , Choi Gi-Hong , Robles-Campos Ricardo , Wang Xiaoying , Sutcliffe Robert P. , Lai Eric C. H. , Chong Charing C. N. , D’Hondt Mathieu , Monden Kazuteru , Lopez-Ben Santiago , Kingham T. Peter , Ferrero Alessandro , Ettorre Giuseppe Maria , Cherqui Daniel , Liang Xiao , Soubrane Olivier , Fuks David , Wakabayashi Go , Troisi Roberto I. , Cheung Tan-To , Sugioka Atsushi , Long Tran Cong duy , Abu Hilal Mohammad , Aldrighetti Luca , Chen Kuo-Hsin , Han Ho-Seong , Goh Brian K. P. ,   International robotic and laparoscopic liver resection study group investigators
Published: June 2024

Objective:
We aimed to establish global benchmark outcomes indicators for L-RPS/H67.

Background:
Minimally invasive liver resections has seen an increase in uptake in recent years. Over time, challenging procedures as laparoscopic right posterior sectionectomies (L-RPS)/H67 are also increasingly adopted.

Methods:
This is a post hoc analysis of a multicenter database of 854 patients undergoing minimally invasive RPS (MI-RPS) in 57 international centers in 4 continents between 2015 and 2021. There were 651 pure L-RPS and 160 robotic RPS (R-RPS). Sixteen outcome indicators of low-risk L-RPS cases were selected to establish benchmark cutoffs. The 75th percentile of individual center medians for a given outcome indicator was set as the benchmark cutoff

Results:
There were 573 L-RPS/H67 performed in 43 expert centers, of which 254 L-RPS/H67 (44.3%) cases qualified as low risk benchmark cases. The benchmark outcomes established for operation time, open conversion rate, blood loss ≥500 mL, blood transfusion rate, postoperative morbidity, major morbidity, 90-day mortality and textbook outcome after L-RPS were 350.8 minutes, 12.5%, 53.8%, 22.9%, 23.8%, 2.8%, 0% and 4% respectively.

Conclusions:
The present study established the first global benchmark values for L-RPS/H6/7. The benchmark provided an up-to-date reference of best achievable outcomes for surgical auditing and benchmarking.
Comparison of microbial and sono-assisted alkaline pre-treatment of sugarcane bagasse, followed by one-pot synthesis of microbial extracellular polymeric substance through simultaneous delignification, saccharification, and fermentation
Authors: Debnath Ankita , Bhowmick Sundipan , Sen Ramkrishna 
Published: June 2024

AbstractLignocellulosic biomass (LCB) captures a major fraction of agro-industrial wastes that are mostly valorised for the production of second-generation biofuels. The extensive pre-treatment followed by saccharification of LCB restricts its usability for the production of a wide array of bioproducts. This study highlights the performance comparison of sono-assisted alkaline pre-treatment versus microbial pre-treatment of sugarcane bagasse by a no. of analytical techniques such as FTIR, XRD, CHNS, and SEM. Moreover, simultaneous delignification, saccharification and fermentation (SDSF) in one pot is highly desirable for the cost effective and environment friendly production of microbial products. In the present study SDSF was carried out by a cellulolytic bacteriumCellulomonas flavigena,for the production of extracellular polymeric substance (EPS), which is, by chemical nature a biopolymer made up of carbohydrate and protein subunits. The biopolymer was found to have an overall positive charge as analysed by ion exchange chromatography. Two major fractions of molecular weight 237 KDa and 29 KDa were obtained from gel filtration chromatography, in addition to that, the EPS was found to be composed of monosaccharides, D (+) mannosamine and D (+) xylose as identified from high pressure liquid chromatography (HPLC).
An Automated Machine Learning Framework for Antimicrobial Resistance Prediction Through Transcriptomics
Authors: Alsiyabi Adil , Shahid Syed Ahsan , Al-Harrasi Ahmed 
Published: June 2024

AbstractThe emergence of antimicrobial resistance (AMR) poses a global threat of growing concern to the healthcare system. To mitigate the spread of resistant pathogens, physicians must identify the susceptibility profile of every patient’s infection in order to prescribe the appropriate antibiotic. Furthermore, disease control centers need to be able to accurately track the patterns of resistance and susceptibility of pathogens to different antibiotics. To achieve this, high-throughput methods are required to accurately predict the resistance profile of a pathogenic microbe in an automated manner. In this work, a transcriptomics-based approach utilizing a machine learning framework is used to achieve this goal. The study highlights the potential of using gene expression as an indicator of resistance to different antibiotics. Results indicate the importance of starting with a high-quality training dataset containing high genetic diversity and a sufficient number of resistant samples. Furthermore, the performed analysis reveals the importance of developing new methods of feature reduction specific to transcriptomic data. Most importantly, this study serves as a proof-of-concept to the potential impact of deploying such models to reduce the mortality rate associated with AMR.
Early to Middle Pleistocene transition shapes the evolution of human-specific mutations associated with height and basal metabolic rate
Authors: Zhang Yufeng , Wang Jie , Yi Chuanyou , Su Yue , Yin Zi , Zhang Shuxian , Wang Ke , Huang He , Li Jin , Fan Shaohua 
Published: June 2024

AbstractUnderstanding the genetic basis of modern-human-specific traits is essential for elucidating the formation of anatomically modern humans (AMHs). Here, we studied the genetic underpinnings of height and basal metabolic rate (BMR), which have undergone extensive modifications in AMHs compared to otherHomospecies and apes. The results revealed a significant genetic correlation between the two traits. The evolution of the variants associated with height and BMR was heavily influenced by environmental factors, marked by two bursts during the Early to Middle Pleistocene transition and one afterward, accounting for 37.4% of the inferred causal variants for height and BMR. We identified an AMH-specific mutation, rs34590044-A, which emerged around 981,916 years ago, coinciding with the first burst of variants associated with increased height and BMR. rs34590044-A upregulates the expression ofACSF3via increasing its enhancer activity, leading to increased mitochondrial function, body length, and BMR exclusively in mice fed essential amino acids, specifically threonine-enriched diets, which are characteristic of meat-based diets. Therefore, the emergence of rs34590044-A may contribute to the shift from an herbivorous to a carnivorous diet in AMHs. Our results underscore the complex interplay between genetics and environment in shaping the crucial phenotypes and physiological traits of AMHs.
Shaving black fur uncovers hidden issues in p16-3MR mice
Authors: Hori Nozomi , Kawamoto Shimpei , Uemura Ken , Okumura Yumiko , Tanaka Kentaro , Park Jeong Hoon , Ohtani Naoko , Motooka Daisuke , Hara Eiji 
Published: June 2024

ABSTRACTThe p16-3MR mouse model has previously been reported to effectively visualize and eliminate senescent cellsin vivo. However, we now report significant issues with this model. Noninvasive bioluminescence imaging without shaving the black fur detected almost no luminescence signals, but they became visible after shaving. However, these signals were very faint and attributed to the auto-luminescence of coelenterazine-h, rather than reporter gene expression. Further experiments showed no significant bioluminescent changes with aging, doxorubicin treatment, or during wound healing, contradicting earlier reports. Comparative analysis between p16-3MR mice from different sources revealed no differences, suggesting functional issues with Renilla luciferase (Rluc) and herpes simplex virus 1 thymidine kinase (HSV-TK) expression in this mouse model. Our findings underscore the necessity of using white-furred mice or ensuring proper fur shaving for accuratein vivobioluminescence imaging. We recommend the reevaluation of previously published studies that used p16-3MR mice without proper controls to ensure data accuracy. These results provide critical insights for researchers using p16-3MR mice in senescence studies.
Drivers of plant-associated invertebrate community structure in West-European coastal dunes
Authors: Van De Walle Ruben , Dahirel Maxime , Langeraert Ward , Benoit Dries , Vantieghem Pieter , Vandegehuchte Martijn L. , Massol François , Bonte Dries 
Published: June 2024

AbstractThe organisation of species assemblages is affected by environmental factors acting at different spatial scales. To understand the drivers behind the community structure of invertebrates associated with marram grass -the dominant dune-building ecosystem engineer in European coastal dunes-, we set up a stratified sampling scheme in six biogeographic sectors along the North Sea. We tested to which degree local invertebrate species composition is affected by the spatial organisation of marram grass tussocks. We used distance-based RDA and a joint species distribution modelling approach to understand how species traits and their phylogeny contribute to invertebrate community composition. We show biogeography to be the most important driver, followed by species-specific responses to marram grass cover and vitality. Traits and phylogeny had a minor influence on the species distribution patterns. The residual species covariation suggests negative interactions between groups of specialist and generalist species. From an applied perspective, our research indicates that the biological value of nature-based solutions for the restoration and design of coastal dunes can be optimized by the design of a heterogeneous marram grass planting scheme and/or development.
Urbanization as an environmental filter for megacolorful birds
Authors: Nascimento Lucas Ferreira do , Guimarães Paulo R. , Evans Julian , Kissling W. Daniel 
Published: June 2024

AbstractThe colorfulness of bird plumage plays a crucial role in intraspecific (e.g. sexual display) and interspecific ecological interactions (e.g. camouflage and predation). Consequently, bird plumage colorfulness can affect the success of individuals in novel environments, such as urban settings. However, our understanding of the impact of urbanization on the plumage colorfulness of birds, especially in tropical regions, is limited. To address this gap, we analyzed whether urban environments serve as environmental filters for plumage colorfulness in passerine (Passeriformes) bird assemblages across the biomes of Brazil, the world’s largest tropical country. Using generalized linear models that incorporate bird checklists, functional traits, and a continuous urbanization metric, we show that urbanization increases specific traits that are associated with plumage colorfulness in bird assemblages (i.e. proportion of omnivores, proportion of larger species, and average sexual dichromatism). While the average colorfulness of bird assemblages did not change with increasing urbanization, a negative correlation between the presence of megacolorful birds (i.e. the 5% most colorful species) and urbanization was detected, particularly in biomes with high urban concentrations, such as the Atlantic Forest and the Caatinga. This suggests that urban environments can be unsuitable for the most colorful tropical bird species. Our study additionally shows that factors like body size, diet, and sexual dichromatism play a mediating role in the urban filtering process. Our analyses provide insights into how urban environments act as environmental filters and can help to better understand the consequences of urbanization for tropical biodiversity.
Conserved Noncoding Cis-Elements Associated with Hibernation Modulate Metabolic and Behavioral Adaptations in Mice
Authors: Steinwand Susan , Stacher Hörndli Cornelia , Ferris Elliott , Emery Jared , Gonzalez Murcia Josue D. , Rodriguez Adriana Cristina , Leydsman Tyler C. , Chaix Amandine , Thomas Alun , Davey Crystal , Gregg Christopher 
Published: June 2024

AbstractOur study elucidates functional roles for conservedcis-elements associated with the evolution of mammalian hibernation. Genomic analyses found topologically associated domains (TADs) that disproportionately accumulated convergent genomic changes in hibernators, including the TAD for theFat Mass & Obesity(Fto) locus. Some hibernation-linkedcis-elements in this TAD form regulatory contacts with multiple neighboring genes. Knockout mice for thesecis-elements exhibitFto, Irx3,andIrx5gene expression changes, impacting hundreds of genes downstream. Profiles of pre-torpor, torpor, and post-torpor phenotypes found distinct roles for eachcis-element in metabolic control, while a high caloric diet uncovered different obesogenic effects. Onecis-element promoting a lean phenotype influences foraging behaviors throughout life, affecting specific behavioral sequences. Thus, convergent evolution in hibernators pinpoints functional genetic mechanisms of mammalian metabolic control.One-sentence summaryDeletions of conservedcis-elements tied to hibernator evolution causes diverse metabolic traits in mice.
An intricate balancing act: Upstream and downstream frameshift co-regulatory elements
Authors: Lee Samuel , Yan Shuting , Dey Abhishek , Laederach Alain , Schlick Tamar 
Published: June 2024

AbstractTargeting ribosomal frameshifting has emerged as a potential therapeutic intervention strategy against Covid-19. During ribosomal translation, a fraction of elongating ribosomes slips by one base in the 5′direction and enters a new reading frame for viral protein synthesis. Any interference with this process profoundly affects viral replication and propagation. For Covid-19, two RNA sites associated with ribosomal frameshifting for SARS-CoV-2 are positioned on the 5′and 3′of the frameshifting residues. Although much attention has been on the 3′frameshift element (FSE), the 5′stem-loop (attenuator hairpin, AH) can play a role. The formation of AH has been suggested to occur as refolding of the 3′RNA structure is triggered by ribosomal unwinding. However, the attenuation activity and the relationship between the two regions are unknown. To gain more insight into these two related viral RNAs and to further enrich our understanding of ribosomal frameshifting for SARS-CoV-2, we explore the RNA folding of both 5′and 3′regions associated with frameshifting. Using our graph-theory-based modeling tools to represent RNA secondary structures, “RAG” (RNA-As-Graphs), and conformational landscapes to analyze length-dependent conformational distributions, we show that AH coexists with the 3-stem pseudoknot of the 3′FSE (graph 3_6 in our dual graph notation) and alternative pseudoknot (graph 3_3) but less likely with other 3′FSE alternative folds (such as 3-way junction 3_5). This is because an alternative length-dependent Stem 1 (AS1) can disrupt the FSE pseudoknots and trigger other folds. In addition, we design four mutants for long lengths that stabilize or disrupt AH, AS1 or FSE pseudoknot to illustrate the deduced AH/AS1 roles and favor the 3_5, 3_6 or stem-loop. These mutants further show how a strengthened pseudoknot can result from a weakened AS1, while a dominant stem-loop occurs with a strengthened AS1. These structural and mutational insights into both ends of the FSE in SARS-CoV-2 advance our understanding of the SARS-CoV-2 frameshifting mechanism by suggesting a sequence of length-dependent folds, which in turn define potential therapeutic intervention techniques involving both elements. Our work also highlights the complexity of viral landscapes with length-dependent folds, and challenges in analyzing these multiple conformations.
Metal Halide Perovskite Solar Module Encapsulation Using Polyolefin Elastomers: The Role of Morphology in Preventing Delamination
Authors: Jiao Haoyang , Hegde Maruti , Li Nengxu , Owen-Bellini Michael , Schelhas Laura , Dingemans Theo J. , Huang Jinsong 
Published: June 2024

The development of perovskite solar cells (PSCs) has ushered in a new era of solar technology, characterized by its exceptional efficiency and cost-effective production. However, the soft and fragile nature of perovskites makes module encapsulation challenging. Polyolefin elastomers (POEs) have been reported to be promising encapsulants for perovskite modules. However, little research exists on identifying criteria among different types of POEs as encapsulants. Here, two POEs with different morphologies were compared as encapsulants. The first POE crystallizes during encapsulation (crystal content ∼40%), and the resulting shrinkage or warpage leads to delamination, causing minimodule failure. In contrast, perovskite minimodules encapsulated with a mostly amorphous POE exhibited better reliability and reproducibility. The best perovskite minimodules passed the thermal cycling test for 240 cycles between −40 and 85 °C and the damp heat test for 1419 h, according to the IEC 61215 standard. This study highlights the importance of the morphology of encapsulants in achieving high-quality encapsulation.

Published by the American Physical Society
2024
Location-based examination of the characteristics of university campuses in Istanbul
Authors: Hacihasanoglu Orhan , Toprak Ilgi 
Published: June 2024

PurposeThe study investigates the connections that university buildings and campuses establish with their environments and the effects of their environments on universities. Many factors influence the location of universities in a particular region. The initial university settlement and the subsequent facilities needed by university branches, colleges, or faculties are related to each other by the time parameter Istanbul, a historical city that is also Turkey’s largest, hosts several state and founding universities. This study investigates the connections between the urban areas where university campuses in Istanbul are located within the city and the specific characteristics of universities.Design/methodology/approachWe evaluate the data on university locations in the city to determine the relationships between their establishment date, size, type, place of location in the city, and unique characteristics. The analysis is based on data for occupancy rate, satisfaction level, university ranking, and space area per student.FindingsResults: Campus areas are affected by the availability of public transport and other amenities in urban areas. There are also interactions between meeting students’ satisfaction, university ranking, and public perceptions of the university and campus location in the city.Originality/valueThis study investigates the connections between the urban areas where university campuses in Istanbul are located within the city and the specific characteristics of universities.
The power of governance: unraveling the influence of voluntary disclosure on bank’s value in Pakistan
Authors: Irfan Fizza , Usman Muhammad , Bashir Zahid , Iqbal Sabeeh 
Published: June 2024

Purpose
This study aims to examine the influence of voluntary disclosure on bank value in Pakistan, considering the moderating effect of corporate governance characteristics: ownership control, board independence and board size.

Design/methodology/approach
The study uses data from 20 listed Pakistani banks for the period 2011–2021. The estimation contains robust fixed effect and its assumptions, and a model of standard error with panel corrections.

Findings
The findings revealed a weak positive impact of voluntary disclosure on bank value. However, the increase in the number of independent directors strengthens the positive impact of voluntary disclosure on a bank’s value. Conversely, increasing the ownership concentration, and board size (other than independent directors) may strongly decrease the impact of voluntary disclosure on a bank’s value in Pakistan.

Research limitations/implications
The study’s limitations include its exclusive focus on the Pakistani banking industry. Future research should take into account newer contexts and data. The findings suggest that future research should investigate the topic in various contexts, including a comparison of Islamic and conventional banks.

Practical implications
The practical implications for Pakistani banks emphasize transparency, board composition and ownership structure. In terms of managerial implications, using independent directors, aligning ownership interests and addressing disclosure challenges are highlighted.

Originality/value
Focusing on independent directors, ownership concentration and board size, this study enhances knowledge of the impact of voluntary disclosure on bank value in Pakistan. It contributes to agency theory and the literature in this domain.
Speaking success: managerial tone in earnings conference calls and financial performance
Authors: Alta'any Mohammad , Kayed Salah , Meqbel Rasmi , Albitar Khaldoon 
Published: June 2024

Purpose
Drawing on signalling and impression management theories, this study aims to examine a bidirectional association between managerial tone in earnings conference calls and financial performance.

Design/methodology/approach
The sample includes non-financial firms listed in the FTSE 350 index during the period 2010–2015. Managerial tone was measured using positive and negative keywords based on the Loughran-McDonald Sentiment Word Lists, while return on assets was used as a proxy for firms’ financial performance.

Findings
The findings indicate that current financial performance positively affects the managerial tone in earnings conference calls. Likewise, the results also show that there is a positive relationship between managerial tone in earnings conference calls and firms’ future financial performance.

Practical implications
The results have important implications for top management to use more virtual communication media (i.e. earnings conference calls) to continue managing their relationships with financial stakeholders and helping them better understand financial performance, especially in countries where holding such calls is not yet part of firms’ policy.

Originality/value
To the best of the authors’ knowledge, this is one of the first studies that explore the relationship between managerial tone in earnings conference calls and financial performance. Overall, this study contributes to managerial tone literature and holds significant theoretical and practical implications.