bluuebunny/crossref_metadata_2025_split huggingface dataset:
O-077 EXPOSOME CHARACTERIZATION OF DIESEL ENGINE EXHAUST EXPOSURE
Authors: Lan Qing , Vermeulen Roel , Rahman Mohammad , Dai Yufei , Hu Wei , Irving Brooklynn McNeil , Lin Xiangping , Blechter Batel , Chaoyang Dianzhi Ren , Duan Huawei , Wong Jason , Niu Yong , Xu Jun , Chaoyang Wei Fu , Meliefste Kees , Hosgood Dean , Ye Meng , Jia Xiaowei , Meng Tao , Bin Ping , Silverman Debra , Zheng Yuxin , Rothman Nathaniel , Walker Douglas 
Published: July 2024

Abstract

Introduction
Exposure to diesel engine exhaust (DEE) is associated with increased lung cancer risk; however, underlying molecular mechanisms remain unclear. We apply an exposome approach to characterize early biological effects of occupational DEE exposure.

Methods
Plasma samples from 54 diesel engine factory workers and 55 non-exposed control workers were characterized using an integrated exposome platform that combines untargeted gas chromatography (GC-) and liquid chromatography (LC-) with high-resolution mass spectrometry (HRMS). Exposome profiles were evaluated by metabolome-wide association study (MWAS) for molecular features associated with DEE exposure and elemental carbon. Potential molecular mechanisms underlying DEE were further evaluated by integrating exposome profiles with plasma proteomics, urine aminopyrenes and mutagenicity, and buccal gene expression analysis.

Results
GC- and LC-HRMS untargeted analysis detected 68,285 metabolic features. Comparison of DEE-exposed and non-exposed workers identified 772 molecular features associated with exposure at a FDR &lt;5%, including 102 detected using GC-HRMS and 670 detected using LC-HRMS. Molecular networking and annotation identified compounds consistent with DEE exposure, while metabolic pathway enrichment suggest alterations in oxidative stress and endothelial pathways. We conducted a secondary MWAS to link urinary mutagenicity, reflecting systemic exposure to genotoxic/carcinogenic agents, and associated with tumor development and identified 90 molecular features positively associated with urine mutagenicity at FDR&lt;5%.

Discussion
Integration of exposome profiles with protein and genome-wide gene expression identified biological alterations consistent with many of the key characteristics of carcinogens.

Conclusion
Integrated exposome characterization of DEE exposure identified novel DEE biomarkers and biological response profiles in a high exposure setting.
O-079 DO HUMIDIFIER DISINFECTANTS CAUSE LUNG CANCER?: STANDARDIZED INCIDENCE RATIO OF LUNG CANCER IN THE HUMIDIFIER DISINFECTANT VICTIM COHORT
Authors: Ahn Yeon Soon , Park Soyoung , Lee Jongin 
Published: July 2024

Abstract

Introduction
Humidifier Disinfectants(HDs) contained various chemicals, including polyhexamethylene guanidine (PHMG) and oligo(2-(2-ethoxy)ethoxyethyl guanidinium (PGH)), as ingredients. While several respiratory diseases have been recognized as health damages caused by HDs, there is currently no known association with lung cancer. However, a recent PHMG exposure study conducted on rats resulted in lung cancer, and when human alveolar epithelial cells were treated with PHMG, carcinogenesis-related genetic changes were observed. Consequently, there is a need for an epidemiological study on humans.

Methods
The objective of this study was to assess the risk of lung cancer among HD victims. The HD victim cohort was comprised of 7,343 registered claimants. Exposure histories were merged with the Korea National Health Insurance Service(KNHIS) data to assess cancer morbidity between 2002 and 2020. Standardized incidence ratios (SIRs) with reference to Korean were analyzed.

Results
The number of lung cancer cases was 109 in men and 86 in women. The SIRs of lung cancer were 2.77 (N=64, 95% CI=2.13–3.54) in men and 9.18 (N=53, 95% CI=6.87–12.00) in women with a 5-year lag.

Discussion and conclusion
The cohort used in this study consists of claimants who reported health damage caused by HD exposure, which causes a significant selection bias compared to a cohort of individuals solely exposed to HDs. However the majority of claimed diseases were respiratory issues, only a small proportion of confirmed lung cancer cases claimed caused by HDs. Therefore the findings of this study provide valuable insights into the potential association between HDs and the development of lung cancer.
O-080 OCCUPATIONAL EXPOSURE TO CARCINOGENS AMONG MIGRANT WORKERS IN THE UNITED ARAB EMIRATES
Authors: Adam Balazs , Elbarazi Iffat , El-Zaemey Sonia , Sharjah Basema Saddik , Sadig Mohamed El , Abdullahi Aminu S , Fritschi Lin , Sheek-Hussein Mohamud 
Published: July 2024

Abstract

Introduction
Occupational carcinogens may be induced by physical, chemical, biological and organizational workplace hazards. In the United Arab Emirates (UAE), migrant workers account for 80% of labor. Being sometimes employed as unskilled workers and more willing to work in demanding jobs, their vulnerability to harmful exposures may be increased. This study aimed to estimate the prevalence of occupational exposure to carcinogens among migrant workers in the UAE.

Methods
A sample of employees working in construction, cleaning, dry cleaning, mechanic workshops and hair salons were recruited and interviewed. Using OccIDEAS (an online assessment tool), participants were asked questions about their demographics, work history and regular tasks. Exposure to various carcinogens was estimated using the in-built algorithms of OccIDEAS.

Results and discussion
A sample of 1778 workers was included. The sample consisted of workers from Bangladesh (19.2%), India (31%), Nepal (4.7%), Pakistan (29.9%) and the Philippines (4.8%), with the rest from other nationalities. Overall, the prevalence of probable exposure was considerable, with the highest among drivers (96%) and the lowest among laundry workers (52%). Moderate to high exposure was found to 20 different carcinogens. Self-rated health among those who were exposed to carcinogens was significantly lower than among those not exposed (AOR = 0.783, 95% CI [0.638–0.961]).

Conclusion
Exposure to several different carcinogens is relatively common in the UAE among migrant workers. Further policy development and implementation of tailored interventions are needed to prevent exposure to occupational carcinogens and, consequently, to combat occupational cancer in the UAE.
O-081 EPIDEMIOLOGICAL TRENDS OF AGE-STANDARDIZED RATES FOR WORKPLACE ACCIDENTS IN JAPAN (2012–2019)
Authors: Zaitsu Masayoshi , Tsushima Saki , Hirohashi Sora , Niki Shinji 
Published: July 2024

Abstract

Introduction
The aging workforce in Japan poses a growing concern regarding its potential impact on workplace accidents. Nevertheless, there is a lack of epidemiological studies analyzing statistical trends in workplace accidents at the national level.

Methods
We conducted a trend analysis using publicly available national data spanning 2012 to 2019 in Japan. Using age-stratified annual data and statistics from the Reports of Occupational Accidents and Diseases, sourced from the Ministry of Health, Labour, and Welfare, we examined occupational fatalities and workplace accidents requiring a leave of four or more days. Age-standardized rates (ASRs) were calculated using the direct method with 10-year age categories. Temporal trends were assessed with Joinpoint regression analysis.

Results
Occupational fatalities exhibited a significant ASR decline, with an annual percent change (APC) of 5.1% (95% CI 6.8–3.3). However, no significant changes in ASR for overall workplace accidents were observed. Furthermore, when categorized by industry, the healthcare sector demonstrated an increasing ASR trend, with an APC of 2.2% (95% CI 1.1–3.3).

Discussion and conclusion
This study is the first to report the epidemiological trend in workplace accidents in Japan. The findings indicate a positive outcome in the reduction of occupational fatalities in Japan, possibly attributable to improved safety measures and awareness. However, the stability in overall workplace accident rates suggests a need for targeted interventions to mitigate accident risks in the aging workforce, especially in industries with increasing trends, such as healthcare.
O-082 ASSOCIATIONS BETWEEN JOB CONTROL AND ISCHEMIC HEART DISEASE MORTALITY AMONG SWEDISH MEN
Authors: Almroth Melody , Hemmingsson Tomas , Falkstedt Daniel , Kjellberg Katarina 
Published: July 2024

Abstract

Introduction
Previous studies of low job control and IHD mortality have shown mixed results. The aim of this study is to investigate the association between job control and IHD mortality among Swedish men in their mid-50s followed up prospectively while accounting for potential confounding throughout the life-course.

Methods
The study is based on a register-linked cohort of 46,565 men who conscripted for the Swedish military in 1969/1970. Job control was measured using a job-exposure matrix (JEM) linked to the men’s registered occupations in 2005 and categorized into quintiles. They were followed regarding IHD deaths between 2006 and 2020. Cox regression models were used to estimate crude and adjusted hazard ratios. Models were adjusted for childhood socioeconomic position, factors from conscription at age 18 (divorced parents, psychiatric and musculoskeletal diagnoses, emotional control, cognitive ability, body mass index, blood pressure, alcohol consumption, and smoking), highest attained education, and occupational physical workload.

Results
Compared to the highest job control category, those with lower job control had an increased risk of IHD mortality in the crude model (HR 1.40, 95% CI 1.07-1.83 for medium high; HR 1.52, 95% CI 1.17-1.97 for medium; HR 2.13, 95% CI 1.66-2.73 for medium-low; and HR 2.92, CI 95% 2.31-3.69 for low). No significant associations remained in the adjusted model.“

Discussion
This study contributes to previous research through the possibility to adjust for several important explanatory factors. The results are limited to older Swedish men.

Conclusion
Associations between low job control and IHD mortality appear to be non-causal and explained by other life-course factors.
O-084 AUTOIMMUNE MANIFESTATIONS OF OCCUPATIONAL SILICA EXPOSURE IN THE STONE BENCHTOP INDUSTRY, VICTORIA, AUSTRALIA
Authors: SM Gwini , RF Hoy , K Walker-Bone 
Published: July 2024

Abstract

Introduction
Artificial stone typically contains extremely high concentration of crystalline silica (90%). The Stone Benchtop Industry (SBI) in Australia started using artificial stone in the early 2000s but unfortunately practices in the sector including dry-cutting, polishing and inadequate ventilation and respirator use has exposed workers in this industry to a very high risk of silicosis. Silica exposure has also been associated with a range of other clinical complications including systemic autoimmune diseases such as systemic sclerosis, SLE (Lupus), rheumatoid arthritis and Sjogren’s syndrome. Therefore, we investigated the prevalence of a diagnosis of a systemic autoimmune condition and of biomarkers of autoimmune disease including: anti-nuclear antibodies (ANAs); rheumatoid factor (RF) and extractable nuclear antigens (ENAs) in this group of SBI workers.

Methods
From 2019, workers in the SBI in Victoria were offered free health screening for silica-associated conditions. Workers participated in a protocolised program coordinated by an occupational health provider, under the supervision of an occupational physician. The assessment included systematic collection of information about symptoms including joint pains, dry eyes/mouth, Raynaud’s and skin conditions, and blood was taken for assessment of erythrocyte sedimentation rate (ESR), ANAs, ENAs and RF.

Results
Blood-test results from 469 workers were analysed (n=453 males, mean age 41 years and n=175 with a final diagnosis of silicosis). Five workers had received a diagnosis of an autoimmune condition. RF&gt;14 IU/mL was found in 8.5% and 3.7% of workers with and without silicosis, respectively (p=0.062). ANA was detected in 103 workers (n=52/137, 38.0% silicosis cases and n=51/236, 21.6% without silicosis, p=0.001) and was present in titres usually regarded as clinically significant in 54 workers. ENA was positive in 9.8% (with no significant differences between diagnosis groups).

Discussion and conclusion
In this young, predominantly male cohort of SBI workers, considerably increased rates of detectable ANAs, ENAs and RF indicate that silica exposure has triggered autoimmune activation. Whilst few workers were identified to have manifested clinical autoimmune disease currently, there is potential for a high rate of incident disease in future and longitudinal follow-up is required.
P-100 OCCUPATIONAL EXPOSURE AND CO-EXPOSURE TO PHYSICAL CONSTRAINTS AND NEUROTOXIC CHEMICALS IN FRENCH WORKERS: RESULTS FROM THE SUMER STUDY
Authors: Bodin Julie , Babin Jessica , Bertin Mélanie , Roquelaure Yves 
Published: July 2024

Abstract

Introduction
Given the high incidence of carpal tunnel syndrome in the working population and the co-exposure of workers, it is necessary to improve knowledge of the joint effects of physical and chemical exposures in order to improve prevention strategies. The aim of this study was to assess the prevalence of occupational exposure and co-exposure to physical constraints and neurotoxic chemicals.

Methods
The study sample was composed of 26,444 workers included in the French cross-sectional survey SUMER 2017s. Occupational exposure within the previous week of work were assessed using a questionnaire during face-to-face interviews with occupational physicians. Four physical constraints were studied: manual handling of loads, forceful joints exertion, repetitive movement and hand-arm transmitted vibrations. Nineteen neurotoxic chemicals were studied: perchloroethylene, trichloroethylene, white-spirit, formaldehyde, etc. Analyses were conducted using weighted data.

Results
Approximately 24% of men and 11% of women were exposed to at least one physical constraint, and 14% of men and 12% of women were exposed to at least one neurotoxic chemical. About 6% of men and 3% of women were co-exposed to physical constraints and neurotoxic chemicals. Male and female workers under 30 years old and blue-collar workers were more co-exposed than other workers. Male workers in the construction were more co-exposed than other male workers.

Discussion
Despite the frequency of co-exposures, very few data are available in the literature on the combined effects of physical and neurotoxic chemical exposures on the risk of CTS.

Conclusion
Occupational co-exposure to physical constraints and neurotoxic chemicals was observed in a significant proportion of French workers.
P-104 MORBIDITIES AMONG ALCOHOL BREWERY WORKERS IN INDIA
Authors: Mhalshekar Sweta , Mhalshekar Vishwaraj 
Published: July 2024

Abstract

Introduction
The alcohol brewery industry produces alcoholic beverages, and it has become a global industry. Brewery workers may be exposed to occupational hazard such as noise and exposure to chemicals. They might also be susceptible to alcohol-related health issues. The study aimed to assess specific morbidities among alcohol brewery workers in India and recommend measures to minimize hazards.

Methods
A retrospective record-based cross-sectional study was conducted over a period of 3 months. The data of 115 workers was obtained and was analyzed using SPSS version 23. Chi-square test was used to find association between qualitative variables.

Results
The records of 115 workers were analyzed, out of which 91.3% were male and 8.69% were females. It was observed that 31.3% were overweight with a BMI of &gt; 25, 13% workers were hypertensive, 0.8% had abnormal ECG findings, 5.2% were diabetic, 13.9% had far vision deficit, 24.3% had near vision and 1.7% had anemia. 6.9% of the workers had abnormal audiometry tests. Liver function tests were deranged in 7.2% of the workers.

Discussion
The workers of alcohol brewery suffer from several occupational health problems such as hearing impairments and abnormal liver functions as well as lifestyle diseases like diabetes, hypertension and obesity.

Conclusion
This study stresses the need for regular health surveillance of workers in an alcohol brewery to detect any deviations from heath along with information, instruction and training on use of appropriate PPE. Lifestyle modifications such as exercise and healthy diet should be inculcated amongst the workers to prevent non communicable diseases.
P-106 OCCUPATIONAL CLASS AND RISK OF PARKINSON’S DISEASE: A CASE-CONTROL STUDY-BASED DATA FROM A NATIONWIDE HOSPITAL GROUP IN JAPAN
Authors: Nakazawa Shoko , Fukai Kota , Furuya Yuko , Hoshi Keika , Kojimahara Noriko , Toyota Akihiro , Tatemichi Masayuki 
Published: July 2024

Abstract

Introduction
This study investigates the association of occupational class with Parkinson’s disease (PD).

Methods
This was a nationwide, multicenter, hospital-based matched case-control study included patients with PD (ICD–10, G20) and controls without mental/ behavioral disorders or nervous system diseases (ICD–10, F, G), aged ≥ 20 years who were initially hospitalized between 2005 and 2020. 10 controls matched by age, sex, admission year and hospital were selected for each case. Participants were grouped into the 12 longest-held occupational class by the Japanese Standard Occupational Classification and Japanese Standard Industrial Classification. We conducted conditional logistic regressions to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for risks of PD adjusted for alcohol consumption and smoking status.

Results
There were 2,077 cases and 20,368 controls. Service workers in service industry were set as reference. Professionals in service industry and white-collar industry showed higher risk of PD (ORs=2.35 (1.48–3.73) and 1.35 (1.15–1.59)). Stratified with smoking status, professionals in service industry remained an increased risk of PD in current smokers. Current and former smokers had lower risks of PD (0.36 (0.30–0.43) and 0.73 (0.66–0.80)). Furthermore, researchers (2.97 (1.06–8.28)), doctors/ dentists/veterinarians/ pharmacists (1.84 (1.17–2.87)), religious workers (2.31 (1.09–4.91)), musicians and stage designers (4.55 (1.39–14.8)) showed higher risk of PD.

Discussion
Although smoking had an inhibitory effect on PD, there were risk in specific professionals. It is significant to clarify the occupational factors that increase risk of PD.

Conclusion
Occupational class was possibly associated with PD risk.
P-110 TRENDS IN THE PREVALENCE RATE RATIO OF CHRONIC DISEASES AT A SEMICONDUCTOR COMPANY COMPARED TO THE NATIONAL PREVALNCE RATE
Authors: Na Wonwoong , Hong Dongui , Lee Jiae , Kwon Hyukhwa , Cho Jaehyun , Kim Gawon , Heo Jieun 
Published: July 2024

Abstract

Introduction
The SK hynix Employee Cohort (SHE cohort) was launched in 2017 to identify the causes of occupational diseases in the semiconductor industry and to conduct various research activities to promote the health of its members. The SHE cohort is a dynamic cohort with 25,505 participants as of December 2022.

Methods
In order to prevent occupational diseases in the semiconductor industry and improve the health of employees, SK hynix organized the Committee for Advanced and Sustainable Occupational Health in 2017 and analyzes the prevalence of chronic diseases annually. As a control group for comparison, data from the Korea National Health and Nutrition Examination Survey from 2017 to 2021 were standardized by age and gender to obtain the prevalence rate ratio (PRR), which was analyzed using the empirical quantile method for five-year trends.

Results
The average PRR for hypertension over the five-year period was 0.49, with an annual percent change(APC) value of -2.44. The mean PRR and APC for diabetes prevalence was 0.78 and 2.30 respectively and the mean PRR and APC for dislipidemia prevalence was 0.66 and 5.53 respectively. The mean PRR for obesity was 0.97 with an APC of -0.49, and the mean PRR for metabolic syndrome was 0.72 with an APC of -1.17.

Discussion and conclusion
There were no statistically significant trends. For all chronic diseases, a low PRR can be interpreted as a health worker effect. Obesity had a relatively high PRR, which should be considered when prioritizing the allocation of healthcare resources in the workplace.
P-111 HEAVY METALS BLOOD LEVEL ASSESSMENT AMONG WORKERS LIVING IN HEAVY METALS EXPOSED AREA IN JAVA ISLAND, INDONESIA
Authors: Fitriani Dewi Yunia , Prodia Mulyana Mulyana , Istiani Nur , Tebet Ari Prayogo , Bose-O’Reilly Stephan , Mansyur Muchtaruddin 
Published: July 2024

Abstract

Introduction
Lead polluted areas, attributed to the activities of collecting and recycling of used lead acid batteries, are widespread throughout Indonesia, including on Java Island. This presentation is an initial analysis of the study which is aimed to determine the blood levels of various heavy metals among workers residing in heavy metals polluted areas of Java, Indonesia.

Methods
The initial analysis of this cross-sectional study included a total of seventy male workers who reside in lead-exposed areas but work in a variety of industrial settings. Five milliliters of whole blood was drawn and stored using EDTA tube. The metal levels were measured by Inductively coupled plasma mass spectrometry (ICP-MS). The socio-demographic characteristics of the respondents were gathered using questionnaires. The Research Ethics Committee of Faculty of Medicine at Universitas Indonesia has approved the study in March 2023.

Results & discussion
There were 23,9% of respondents, aged between 20 and 62 years old, working directly exposed to heavy metals, as welders, smelting labor, and battery seller. Results showed that blood Lead, cadmium and chromium levels were significantly higher in the respondents working exposed to heavy metals with P&lt;0,001, P=0,02, and P=0,03 consecutively. There was no significant difference for other metals such as Mangan, Arsenic, and Cobalt. No significant age-based differences were found in terms of all metals.

Conclusion
The occupational exposure remains a significant contributor to elevated heavy metal blood levels, regardless of their living area. This also showed the importance of workplace intervention to control the exposures.
P-116 RELATIONSHIP BETWEEN DAILY SLEEP DURATION AND METABOLIC SYNDROME-RELATED ITEMS IN POLICE OFFICERS
Authors: Nogawa Kazuhiro , Sakuma Sayaka , Watanabe Yuuka , Suwazono Yasushi 
Published: July 2024

Abstract

Introduction
Many police officers tend to have irregular lifestyles due to shift work, investigative activities, etc., and many of them do not get enough sleep. We examined the relationship between sleep duration and findings of metabolic syndrome-related items in annual health examinations among police officers.

Methods
The participants were 9,633 men and 1,086 women who underwent the legally-required annual health screenings in a Prefectural Police. Based on this self-administered questionnaire, we obtained information on daily sleep duration. Fisher’s exact test was performed on the prevalence of obesity, hypertension, lipids, blood sugar, and metabolic syndrome, respectively, based on the results of the medical examinations.

Results
Short sleep duration (≤5 hours) was significantly related to obesity, hypertension, metabolic syndrome, and blood glucose in men. In women, only lipid was significant.

Discussion
In police officers, a comparison of sleep duration and prevalence of metabolic syndrome-related items revealed significant associations in a number of items. The importance of ensuring adequate sleep hours for maintaining good health was demonstrated.

Conclusion
It needs to promote various health measures such as lifestyle disease countermeasures and promotion of work-life balance, not merely longer or shorter work hours, but more importantly, whether or not sleep is being obtained.