bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saving the critically injured trauma patient: a retrospective analysis of 1000 uses of intraosseous access
Authors: Lewis Philippa , Wright Chris 
Published: July 2014

ObjectiveIntraosseous access (IO) is becoming increasingly accepted in adult populations as an alternative to peripheral vascular access; however, there is still insufficient evidence in large patient groups supporting its use.MethodsRetrospective review. This paper reports on the use of IO devices over a 7-year period from August 2006 to August 2013 during combat operations in Afghanistan. A database search of the Joint Theatre Trauma Registry (JTTR) was carried out looking for all the incidences of IO access use during this time. Excel (Microsoft) was used to manage the dataset and perform descriptive statistics on the patient demographics, injuries, treatments and complications that were retrieved.Results1014 IO devices were used in 830 adult patients with no major complications. The rate of minor complications, the majority of which were device failure, was 1.38%. 5124 separate infusions of blood products or fluids occurred via IO access, with 36% being of packed red cells. On average, each casualty received 6.95 different infusions of blood products and fluids, and 3.28 separate infusions of drugs through IO access. 32 different drugs were infused to 367 patients via IO, the most frequent being anaesthetic agents. IO access was used in the prehospital environment, during tactical helicopter evacuation and within hospitals.ConclusionsIO access can be used to administer a wide variety of life-saving medications quickly, easily and with low-complication rates. This highlights its valuable role as an alternative method of obtaining vascular access, vital when resuscitating the critically injured trauma patient.
Non-alcoholic fatty liver disease is associated with higher levels ofobjectivelymeasured sedentary behaviour and lower levels of physical activity than matched healthy controls
Authors: Hallsworth Kate , Thoma Christian , Moore Sarah , Ploetz Thomas , Anstee Quentin M , Taylor Roy , Day Christopher P , Trenell Michael I 
Published: July 2014

Background and aimsPhysical activity is a key determinant of metabolic control and is recommended for people with non-alcoholic fatty liver disease (NAFLD), usually alongside weight loss and dietary change. To date, no studies have reported the relationship betweenobjectivelymeasured sedentary behaviour and physical activity, liver fat and metabolic control in people with NAFLD, limiting the potential to target sedentary behaviour in clinical practice. This study determined the level of sedentary behaviour and physical activity in people with NAFLD, and investigated links between physical activity, liver fat and glucose control.MethodsSedentary behaviour, physical activity and energy expenditure were assessed in 37 adults with NAFLD using a validated multisensor array over 7 days. Liver fat and glucose control were assessed, respectively, by1H-MRS and fasting blood samples. Patterns of sedentary behaviour were assessed by power law analyses of the lengths of sedentary bouts fitted from raw sedentary data. An age and sex-matched healthy control group wore the activity monitor for the same time period.ResultsPeople with NAFLD spent approximately half an hour extra a day being sedentary (1318±68 vs1289±60 mins/day; p<0.05) and walked 18% fewer steps (8483±2926 vs 10377±3529 steps/day; p<0.01). As a consequence, active energy expenditure was reduced by 40% (432±258 vs 732±345 kcal/day; p<0.01) and total energy expenditure was lower in NAFLD (2690±440 vs 2901±511 kcal/day; p<0.01). Power law analyses of the lengths of sedentary bouts demonstrated that patients with NAFLD also have a lower number of transitions from being sedentary to active compared with controls (13±0.03 vs15±0.03%; p<0.05).ConclusionsPeople with NAFLD spend more time sedentary and undertake less physical activity on a daily basis than healthy controls. High levels of sedentary behaviour and low levels of physical activity represent a therapeutic target that may prevent progression of metabolic conditions and weight gain in people with NAFLD and should be considered in clinical care.
A Survey and Classification of Storage Deduplication Systems
Authors: Paulo João , Pereira José 
Published: July 2014

The automatic elimination of duplicate data in a storage system, commonly known as deduplication, is increasingly accepted as an effective technique to reduce storage costs. Thus, it has been applied to different storage types, including archives and backups, primary storage, within solid-state drives, and even to random access memory. Although the general approach to deduplication is shared by all storage types, each poses specific challenges and leads to different trade-offs and solutions. This diversity is often misunderstood, thus underestimating the relevance of new research and development.
The first contribution of this article is a classification of deduplication systems according to six criteria that correspond to key design decisions: granularity, locality, timing, indexing, technique, and scope. This classification identifies and describes the different approaches used for each of them. As a second contribution, we describe which combinations of these design decisions have been proposed and found more useful for challenges in each storage type. Finally, outstanding research challenges and unexplored design points are identified and discussed.
Design of an Interactive Experience with Medieval Illuminations
Authors: Correia N. , Romão T. , Ricardo A. , Mota T. , Melo M. J. , Castro R. , Carvalho R. , Miranda A. 
Published: July 2014

This article presents the design, implementation, and evaluation of an interactive installation to explore color in medieval illuminations and their context. The main goal of the installation is to promote wide dissemination of Portuguese medieval illuminations as well as to achieve engagement of the public in the conservation of this treasured heritage. The interactive installation is based on the experience and results obtained in a series of hands-on workshops, where “real” colored paints were produced using techniques and pigments similar to the originals.
The design and development process of the interactive installation was carried out by a multidisciplinary team in computer engineering, design, illustration, art history, history, chemistry, and conservation science. The installation, after several iterations on the content and technology, explores innovative computational interfaces and how they can be developed and used in cultural heritage. It has three components that work independently or as a full installation: (1) Virtual Scriptorium, (2) Interactive Panel, and (3) Augmented Book. The design rational, implementation, and evaluation of the modular installation are described, as well as how this work contributes to the wide dissemination of information on these extraordinary medieval manuscripts.
A Retargetable Static Binary Translator for the ARM Architecture
Authors: Shen Bor-Yeh , Hsu Wei-Chung , Yang Wuu 
Published: July 2014

Machines designed with new but incompatible Instruction Set Architecture (ISA) may lack proper applications. Binary translation can address this incompatibility by migrating applications from one legacy ISA to a new one, although binary translation has problems such as code discovery for variable-length ISA and code location issues for handling indirect branches. Dynamic Binary Translation (DBT) has been widely adopted for migrating applications since it avoids those problems. Static Binary Translation (SBT) is a less general solution and has not been actively researched. However, SBT performs more aggressive optimizations, which could yield more compact code and better code quality. Applications translated by SBT can consume less memory, processor cycles, and power than DBT and can be started more quickly. These advantages are even more critical for embedded systems than for general systems.
In this article, we designed and implemented a new SBT tool, called LLBT, which translates ARM instructions into LLVM IRs and then retargets the LLVM IRs to various ISAs, including ×86, ×86--64, ARM, and MIPS. LLBT leverages two important functionalities from LLVM: comprehensive optimizations and retargetability. More importantly, LLBT solves the code discovery problem for ARM/Thumb binaries without resorting to interpretation. LLBT also effectively reduced the size of the address mapping table, making SBT a viable solution for embedded systems. Our experiments based on the EEMBC benchmark suite show that the LLBT-generated code can run more than 6× and 2.3× faster on average than emulation with QEMU and HQEMU, respectively.
A Portable Optimization Engine for Accelerating Irregular Data-Traversal Applications on SIMD Architectures
Authors: Ren Bin , Mytkowicz Todd , Agrawal Gagan 
Published: July 2014

Fine-grained data parallelism is increasingly common in the form of longer vectors integrated with mainstream processors (SSE, AVX) and various GPU architectures. This article develops support for exploiting such data parallelism for a class of nonnumeric, nongraphic applications, which perform computations while traversing many independent, irregular data structures. We address this problem by developing several novel techniques. First, for code generation, we develop an intermediate language for specifying such traversals, followed by a runtime scheduler that maps traversals to various SIMD units. Second, we observe that good data locality is crucial to sustained performance from SIMD architectures, whereas many applications that operate on irregular data structures (e.g., trees and graphs) have poor data locality. To address this challenge, we develop a set of data layout optimizations that improve spatial locality for applications that traverse many irregular data structures. Unlike prior data layout optimizations, our approach incorporates a notion of both interthread and intrathread spatial reuse into data layout. Finally, we enable performance portability (i.e., the ability to automatically optimize applications for different architectures) by accurately modeling the impact of inter- and intrathread locality on program performance. As a consequence, our model can predict which data layout optimization to use on a wide variety of SIMD architectures.
To demonstrate the efficacy of our approach and optimizations, we first show how they enable up to a 12X speedup on one SIMD architecture for a set of real-world applications. To demonstrate that our approach enables performance portability, we show how our model predicts the optimal layout for applications across a diverse set of three real-world SIMD architectures, which offers as much as 45% speedup over a suboptimal solution.
Revisiting LP-NUCA Energy Consumption
Authors: Gracia Darío Suárez , Ferrerón Alexandra , Campo Luis Montesano Del , Arnal Teresa Monreal , Yúfera Víctor Viñals 
Published: July 2014

Cache working-set adaptation is key as embedded systems move to multiprocessor and Simultaneous Multithreaded Architectures (SMT) because interthread pollution harms system performance and battery life. Light-Power NUCA (LP-NUCA) is a working-set adaptive cache that depends on temporal-locality to save energy. This work identifies the sources of energy waste in LP-NUCAs: parallel access to the tag and data arrays of the tiles and low locality phases with useless block migration. To counteract both issues, we prove that switching to serial access reduces energy without harming performance and propose a machine learning Adaptive Drop Rate (ADR) controller that minimizes the amount of replacement and migration when locality is low.
This work demonstrates that these techniques efficiently adapt the cache drop and access policies to save energy. They reduce LP-NUCA consumption 22.7% for 1SMT. With interthread cache contention in 2SMT, the savings rise to 29%. Versus a conventional organization, energy--delay improves 20.8% and 25% for 1- and 2SMT benchmarks, and, in 65% of the 2SMT mixes, gains are larger than 20%.
Conquering big data with spark and BDAS
Authors: Stoica Ion 
Published: July 2014

Today, big and small organizations alike collect huge amounts of data, and they do so with one goal in mind: extract "value" through sophisticated exploratory analysis, and use it as the basis to make decisions as varied as personalized treatment and ad targeting. Unfortunately, existing data analytics tools are slow in answering queries, as they typically require to sift through huge amounts of data stored on disk, and are even less suitable for complex computations, such as machine learning algorithms. These limitations leave the potential of extracting value of big data unfulfilled.
To address this challenge, we are developing Berkeley Data Analytics Stack (BDAS), an open source data analytics stack that provides interactive response times for complex computations on massive data. To achieve this goal, BDAS supports efficient, large-scale in-memory data processing, and allows users and applications to trade between query accuracy, time, and cost. In this talk, I'll present the architecture, challenges, results, and our experience with developing BDAS, with a focus on Apache Spark, an in-memory cluster computing engine that provides support for a variety of workloads, including batch, streaming, and iterative computations. In a relatively short time, Spark has become the most active big data project in the open source community, and is already being used by over one hundred of companies and research institutions.
Declarative visitors to ease fine-grained source code mining with full history on billions of AST nodes
Authors: Dyer Robert , Rajan Hridesh , Nguyen Tien N. 
Published: July 2014

Software repositories contain a vast wealth of information about software development. Mining these repositories has proven useful for detecting patterns in software development, testing hypotheses for new software engineering approaches, etc. Specifically, mining source code has yielded significant insights into software development artifacts and processes. Unfortunately, mining source code at a large-scale remains a difficult task. Previous approaches had to either limit the scope of the projects studied, limit the scope of the mining task to be more coarse-grained, or sacrifice studying the history of the code due to both human and computational scalability issues. In this paper we address the substantial challenges of mining source code: a) at a very large scale; b) at a fine-grained level of detail; and c) with full history information.
To address these challenges, we present domain-specific language features for source code mining. Our language features are inspired by object-oriented visitors and provide a default depth-first traversal strategy along with two expressions for defining custom traversals. We provide an implementation of these features in the Boa infrastructure for software repository mining and describe a code generation strategy into Java code. To show the usability of our domain-specific language features, we reproduced over 40 source code mining tasks from two large-scale previous studies in just 2 person-weeks. The resulting code for these tasks show between 2.0x--4.8x reduction in code size. Finally we perform a small controlled experiment to gain insights into how easily mining tasks written using our language features can be understood, with no prior training. We show a substantial number of tasks (77%) were understood by study participants, in about 3 minutes per task.
Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
Authors: Lu Yong-Chen , Yao Xin , Crystal Jessica S. , Li Yong F. , El-Gamil Mona , Gross Colin , Davis Lindy , Dudley Mark E. , Yang James C. , Samuels Yardena , Rosenberg Steven A. , Robbins Paul F. 
Published: July 2014

Abstract
Purpose: Cancer immunotherapy with adoptive transfer of tumor-infiltrating lymphocytes (TIL) represents an effective treatment for patients with metastatic melanoma, with the objective regressions in up to 72% of patients in three clinical trials. However, the antigen targets recognized by these effective TILs remain largely unclear.
Experimental Design: Melanoma patients 2359 and 2591 both experienced durable complete regressions of metastases ongoing beyond five years following adoptive TIL transfer. Two conventional screening approaches were carried out to identify the antigens recognized by these clinically effective TILs. In addition, a novel approach was developed in this study to identify mutated T-cell antigens by screening a tandem minigene library, which comprised nonsynonymous mutation sequences identified by whole-exome sequencing of autologous tumors.
Results: Screening of an autologous melanoma cDNA library using a conventional approach led to the identification of previously undescribed nonmutated targets recognized by TIL 2359 or TIL 2591. In contrast, screening of tandem minigene libraries encoding tumor-specific mutations resulted in the identification of mutated kinesin family member 2C (KIF2C) antigen as a target of TIL 2359, and mutated DNA polymerase alpha subunit B (POLA2) antigen as a target of TIL 2591. Both KIF2C and POLA2 have been found to play important roles in cell proliferation.
Conclusions: These findings suggest that the minigene screening approach can facilitate the antigen repertoire analysis of tumor reactive T cells, and lead to the development of new adoptive cell therapies with purified T cells that recognize candidate-mutated antigens derived from genes essential for the carcinogenesis. Clin Cancer Res; 20(13); 3401–10. ©2014 AACR.
PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells
Authors: Lanahan Anthony A. , Lech Diana , Dubrac Alexandre , Zhang Jiasheng , Zhuang Zhen W. , Eichmann Anne , Simons Michael 
Published: July 2014

Background—
Regulation of vascular endothelial growth factor receptor-2 (VEGFR2) signaling is a control point that determines the extent of vascular tree formation. Recent studies demonstrated an important role played by VEGFR2 endothelial trafficking in control of its activity and suggested the involvement of a phosphotyrosine phosphatase 1b (PTP1b) in this process. This study was designed to define the role of PTP1b in endothelial VEGFR2 signaling and its role in regulation of angiogenesis and arteriogenesis.

Methods and Results—
We generated mice carrying an endothelial-specific deletion of PTP1b and examined the effect of this knockout on VEGF signaling, angiogenesis, and arteriogenesis in vitro and in vivo. PTP1b knockout endothelial cells had increased VEGF-dependent activation of extracellular signal-regulated kinase signaling, sprouting, migration, and proliferation compared with controls. Endothelial PTP1b null mice had increased retinal and Matrigel implant angiogenesis and accelerated wound healing, pointing to enhanced angiogenesis. Increased arteriogenesis was demonstrated by observations of faster recovery of arterial blood flow and large numbers of newly formed arterioles in the hindlimb ischemia mouse model. PTP1b endothelial knockout also rescued impaired blood flow recovery after common femoral artery ligation in synectin null mice.

Conclusions—
PTP1b is a key regulator of endothelial VEGFR2 signaling and plays an important role in regulation of the extent of vascular tree formation.
New palpigrades (Arachnida, Eukoeneniidae) from the Iberian Peninsula
Authors: BARRANCO P. , MAYORAL J. G. 
Published: July 2014

Eighteen specimens of palpigrades captured in seven caves in the provinces of Castellon and Valencia in eastern Spain are studied. We describe and illustrate three new species and a new subspecies: Eukoenenia valencianus sp. nov., Eukoenenia montagudi sp. nov., Eukoenenia sendrai sp. nov. and Eukoenenia patrizii iberica ssp. nov. The Iberian fauna now comprises nine species that we place into two different morphological groups. The relationships between species from eastern Spain and other Mediterranean species are discussed.
Anterior Cruciate Ligament Injury, Return to Play, and Reinjury in the Elite Collegiate Athlete
Authors: Kamath Ganesh V. , Murphy Timothy , Creighton R. Alexander , Viradia Neal , Taft Timothy N. , Spang Jeffrey T. 
Published: July 2014

Background: Graft survivorship, reinjury rates, and career length are poorly understood after anterior cruciate ligament (ACL) reconstruction in the elite collegiate athlete. The purpose of this study was to examine the outcomes of ACL reconstruction in a National Collegiate Athletic Association (NCAA) Division I athlete cohort. Study Design: Case series; Level of evidence, 4. Methods: A retrospective chart review was performed of all Division I athletes at a single public university from 2000 to 2009 until completion of eligibility. Athletes were separated into 2 cohorts: those who underwent precollegiate ACL reconstruction (PC group) and those who underwent intracollegiate reconstruction (IC group). Graft survivorship, reoperation rates, and career length information were collected. Results: Thirty-five athletes were identified with precollegiate reconstruction and 54 with intracollegiate reconstruction. The PC group had a 17.1% injury rate with the original graft, with a 20.0% rate of a contralateral ACL injury. For the IC group, the reinjury rates were 1.9% with an ACL graft, with an 11.1% rate of a contralateral ACL injury after intracollegiate ACL reconstruction. The athletes in the PC group used 78% of their total eligibility (average, 3.11 years). The athletes in the IC group used an average of 77% of their remaining NCAA eligibility; 88.3% of those in the IC group played an additional non-redshirt year after their injury. The reoperation rate for the PC group was 51.4% and was 20.4% for the IC group. Conclusion: Reoperation and reinjury rates are high after ACL reconstruction in the Division I athlete. Precollegiate ACL reconstruction is associated with a very high (37.1%) rate of repeat ACL reinjuries to the graft or opposite knee. The majority of athletes are able to return to play after successful reconstruction.
District nurse advocacy for choice to live and die at home in rural Australia
Authors: Reed Frances M , Fitzgerald Les , Bish Melanie R 
Published: July 2014

Background: Choice to live and die at home is supported by palliative care policy; however, health resources and access disparity impact on this choice in rural Australia. Rural end-of-life home care is provided by district nurses, but little is known about their role in advocacy for choice in care. Objectives: The study was conducted to review the scope of the empirical literature available to answer the research question: What circumstances influence district nurse advocacy for rural client choice to live and die at home?, and identify gaps in the knowledge. Method: Interpretive scoping methodology was used to search online databases, identify suitable studies and select, chart, analyse and describe the findings. Results: 34 international studies revealed themes of ‘the nursing relationship’, ‘environment’, ‘communication’, ‘support’ and ‘the holistic client centred district nursing role. Discussion: Under-resourcing, medicalisation and emotional relational burden could affect advocacy in rural areas. Conclusion: It is not known how district nurses overcome these circumstances to advocate for choice in end-of-life care. Research designed to increase understanding of how rural district nurses advocate successfully for client goals will enable improvements to be made in the quality of end-of-life care offered.