bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism
Authors: Wicks Shawna E. , Vandanmagsar Bolormaa , Haynie Kimberly R. , Fuller Scott E. , Warfel Jaycob D. , Stephens Jacqueline M. , Wang Miao , Han Xianlin , Zhang Jingying , Noland Robert C. , Mynatt Randall L. 
Published: June 2015

Significance
Many theories regarding the causes of insulin resistance in skeletal muscle center on the ability of muscle to oxidize fat, with evidence supporting either decreased or increased fatty acid oxidation (FAO) as causal to insulin resistance. Inhibition of fatty acid transport into mitochondria specifically in mouse muscle results in a rather remarkable phenotype. Despite an accumulation of lipids in muscle, insulin sensitivity is maintained. The muscle responds to decreased FAO by adapting muscle metabolism to use other fuel sources, and by an increased reliance upon peroxisomal fat oxidation. There is also an increase in mitochondrial biogenesis. At the whole-body level, the mice seem to enter an energy conservation mode with reduced activity, energy expenditure, and resistance to diet-induced obesity.
Empirical inference of circuitry and plasticity in a kinase signaling network
Authors: Wilkes Edmund H. , Terfve Camille , Gribben John G. , Saez-Rodriguez Julio , Cutillas Pedro Rodriguez 
Published: June 2015

Significance
Signaling pathways form complex networks of biochemical reactions, but inferring the topology of such networks and measuring how they are remodeled in disease is still challenging. Using MS, our study defined the circuitry and plasticity of a kinase signaling network de novo, with unprecedented depth and without prior assumptions of its topology. In addition, we observed a degree of stochasticity in how the network was remodeled upon chronic inhibition of phosphoinositide 3-kinase (PI3K) or mammalian target of rapamycin complexes 1/2 (mTORC1/2), suggesting that the initial condition of the system was not the only determinant of how cells become resistant to targeted therapies. These observations may have implications for our ability to predict the evolution of signaling networks during therapy to prevent the acquisition of resistance.
Late Oligocene–early Miocene birth of the Taklimakan Desert
Authors: Zheng Hongbo , Wei Xiaochun , Tada Ryuji , Clift Peter D. , Wang Bin , Jourdan Fred , Wang Ping , He Mengying 
Published: June 2015

Significance
The formation of the Taklimakan Desert marked a major geological event in central Asia during the Cenozoic, with far-reaching impacts. Deposition of both eolian sand dunes in the basin center and the genetically equivalent loessite along the basin margins provide evidence for the birth of the Taklimakan Desert. This paper resolves a long-standing debate concerning the age of the Taklimakan Desert, specifically whether it dates to ∼3.4–7 Ma, currently the dominant view. Our result shows that the desert came into existence during late Oligocene–early Miocene, between ∼26.7 Ma and 22.6 Ma, as a result of widespread regional aridification and increased erosion in the surrounding mountain fronts, both of which are closely linked to the tectonic uplift of the Tibetan–Pamir Plateau and Tian Shan.
Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy
Authors: Chiu Wing Sin , Belsey Natalie A. , Garrett Natalie L. , Moger Julian , Delgado-Charro M. Begoña , Guy Richard H. 
Published: June 2015

Significance
Diseases of the nail are particularly hard to treat because drug penetration to the target (which lies below the tightly woven keratin network) is extremely limited. To shed greater light on the problem, the diffusion of three pharmaceutically relevant solvents across the human nail has been imaged and characterized by stimulated Raman scattering microscopy. Remarkably, the kinetics of water transport were more than 10-fold faster than those of dimethyl sulphoxide and propylene glycol. Furthermore, the uptake of all three solvents, the diffusion of which appeared to be concentration dependent, progressively undermined the integrity of the nail. These new insights may facilitate the improved formulation of drug products effective in the treatment of diseases such as fungal infections and nail psoriasis.
Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment
Authors: Zhu Xi , Xu Yingjie , Solis Luisa M. , Tao Wei , Wang Liangzhe , Behrens Carmen , Xu Xiaoyang , Zhao Lili , Liu Danny , Wu Jun , Zhang Ning , Wistuba Ignacio I. , Farokhzad Omid C. , Zetter Bruce R. , Shi Jinjun 
Published: June 2015

Significance
This study developed a new generation lipid–polymer hybrid nanoparticle platform for effective systemic delivery of small interfering RNA (siRNA) to tumors, which represents a challenging hurdle for the widespread application of RNA interference (RNAi) in cancer research and therapy. With promising in vivo features such as long blood circulation, high tumor accumulation, and effective gene silencing, the hybrid siRNA nanoparticles were successfully used to reveal and validate a putative therapeutic target, Prohibitin1 (PHB1), in non-small cell lung cancer treatment. In vivo antitumor efficacy results and human tissue microarray analysis further suggested the feasibility of utilizing PHB1 siRNA nanoparticles as a novel therapeutic agent. This hybrid RNAi nanoparticle platform may serve as a valuable tool for validating potential cancer targets and developing new cancer therapies.
Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling
Authors: den Boon Johan A. , Pyeon Dohun , Wang Sophia S. , Horswill Mark , Schiffman Mark , Sherman Mark , Zuna Rosemary E. , Wang Zhishi , Hewitt Stephen M. , Pearson Rachel , Schott Meghan , Chung Lisa , He Qiuling , Lambert Paul , Walker Joan , Newton Michael A. , Wentzensen Nicolas , Ahlquist Paul 
Published: June 2015

SignificanceCervical cancer (CxCa) is the second most frequent cancer in women and the third leading cause of cancer death in women worldwide. Our global analysis of gene expression in normal, precancerous, and cancerous cervical tissue shows increased DNA replication/repair and cell proliferation followed by substantial metabolic shifts. We observed a dramatic, progressive decrease in estrogen receptor alpha (ERα) in tumor progression, and ranking specimens by estrogen-responsive gene expression correlated remarkably with histopathology. Whereas ERα expression shuts off in tumor epithelium, stromal fibroblasts in the microenvironment retain ERα, and the data indicate estrogen-related alteration of several candidate stroma–tumor signaling pathways. Our findings strongly support a role of stromal estrogen signaling in CxCa development with implications for CxCa management and control.
Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice
Authors: Ohba Takuya , Yoshino Yuta , Ishisaka Mitsue , Abe Naohito , Tsuruma Kazuhiro , Shimazawa Masamitsu , Oyama Masayoshi , Tabira Takeshi , Hara Hideaki 
Published: June 2015

Abstract
Huperzia serrata has been used as a Chinese folk medicine for many years. It contains huperzine A, which has a protective effect against memory deficits in animal models; however, it is unclear if H. serrata extract exerts any effects in Alzheimer’s disease (AD) models. We used H. serrata collected in Japan and determined its huperzine A content using HPLC. We determined its inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. H. serrata extract (30 mg/kg/day) and donepezil (10 mg/kg/day) were orally administrated for 7 days. After repeated administration, we performed the Y-maze and passive avoidance tests. H. serrata extract contained 0.5% huperzine A; H. serrata extract inhibited AChE, but not BuChE. H. serrata extract ameliorated cognitive function in mice. These results indicate that Japanese H. serrata extract ameliorates cognitive function deficits by inhibiting AChE. Therefore, H. serrata extract may be valuable for the prevention or treatment of dementia in AD.
“Dangerous conversations”: a case study involving language
Authors: Madoc-Jones Iolo , Jones Dawn , Parry Odette , Dubberley Sarah 
Published: June 2015

Purpose– Drawing on the approach of Bourdieu (1977, 1986), and using language as an exemplar, the purpose of this paper is to engage in a “dangerous conversation” to explore how and why issues of diversity were mobilised, ignored and leveraged in one particular service context.Design/methodology/approach– Qualitative research exploring the language choices of 25 service users who had been processed through the criminal Justice System in Wales in the last five years.Findings– The argument is made that in some service contexts, a habitus obtains that renders reflexivity about diversity issues problematic and predicates against the critical reflection necessary to promote anti-oppressive practice.Research limitations/implications– Small sample size, not generalisable.Practical implications– The authors intend the paper to encourage greater reflection on instances when diversity issues are raised and to render simplistic any attempt to invalidate claims of discrimination.Social implications– Encourage dialogue about claims of discrimination and greater reflection by service providers about the legitimacy of such claims.Originality/value– Anti-oppressive theorising has, for the most part, constructed minority group members as passive victims within hierarchical power relationships. While acknowledging how power is unequally distributed, the paper challenges hierarchical models which designate minority group members as bereft of power.
Investigating the work practices of network security professionals
Authors: Adnan Muhammad , Just Mike , Baillie Lynne , Kayacik Hilmi Gunes 
Published: June 2015

Purpose– The purpose of this paper is to investigate the work practices of network security professionals and to propose a new and robust work practices model of these professionals.Design/methodology/approach– The proposed work practices model is composed by combining the findings of ten notable empirical studies performed so far this century. The proposed model was then validated by an online survey of 125 network security professionals with a wide demographic spread.Findings– The empirical data collected from the survey of network security professionals strongly validate the proposed work practices model. The results also highlight interesting trends for different groups of network security professionals, with respect to performing different security-related activities.Research limitations/implications– Further studies could investigate more closely the links and dependencies between the different activities of the proposed work practices model and tools used by network security professionals to perform these activities.Practical implications– A robust work practices model of network security professionals could hugely assist tool developers in designing usable tools for network security management.Originality/value– This paper proposes a new work practices model of network security professionals, which is built by consolidating existing empirical evidence and validated by conducting a survey of network security professionals. The findings enhance the understanding of tool developers about the day-to-day activities of network security professionals, consequently assisting developers in designing better tools for network security management.
Impact of the cost of capital on the financing decisions of Brazilian companies
Authors: Albanez Tatiana 
Published: June 2015

Purpose
– The purpose of this paper is to examine the market timing behavior of listed Brazilian companies to verify the effects of the cost of capital on their financing decisions, and hence on their capital structure.

Design/methodology/approach
– The relation between the cost of capital (debt and equity capital) and the leverage of firms in the period from 2000 to 2011 is analyzed by means of regression models with panel data. For this purpose, different proxies are used for the cost of equity and debt capital.

Findings
– The results provide strong evidence that Brazilian firms take advantage of windows of opportunity to obtain financing, and that when the cost of equity capital is high, firms appear to follow a pecking order, giving preference to debt financing. However, the decision is based on the cost of alternative sources of funding rather than just on the hierarchy established by the pecking order theory, due to the information asymmetry between market agents.

Originality/value
– Few studies of the Brazilian capital market have analyzed firms’ capital structure under the market timing approach, and none have addressed the same aspects analyzed here. Therefore, this paper will be useful to different users of accounting information by indicating the factors that influence the capital structure of Brazilian firms, allowing a better analysis of whether these firms act to maximize the generation of shareholder wealth.
Sustainability vs credibility of fiscal consolidation
Authors: Passamani Giuliana , Tamborini Roberto , Tomaselli Matteo 
Published: June 2015

Purpose
– The purpose of this paper is to explain why some countries in the eurozone between 2010 and 2012 experienced a dramatic vicious circle between hard austerity plans and rising default risk premia. Were such plans too small, and hence non-credible, or too large, and hence non-sustainable? These questions have prompted theoretical and empirical investigations in the line of the so-called “self-fulfilling beliefs”, where beliefs of unsustainability of fiscal adjustments, and hence default on debt, feed higher risk premia which indeed make fiscal adjustments less sustainable.

Design/methodology/approach
– Detecting the sustainability factor in the evolution of spreads is uneasy because it is largely non-observable and may be proxied by different variables. In this paper, the authors present the results of a dynamic principal components factor analysis (PCFA) applied to a panel data set of the 11 major EZ countries from 2000 to 2013, consisting of each country’s spread of long-term interest rate over Germany as dependent variable, and an array of leading fiscal and macroeconomic indicators of solvency fiscal effort and its sustainability.

Findings
– The authors have been able to identify the role of these indicators that combine themselves as significant latent variables in boosting spreads. Moreover, the large joint deterioration of these variables is identifiably located between 2009 and 2012 and particularly for the group of countries under most severe default risk (with Italy and France as borderline cases). The authors also find evidence that the announcement of the European Central Bank Outright Monetary Transactions program has improved the sustainability assessment of sovereign debts.

Originality/value
– Dynamic PCFA is a rather unusual technique with respect to standard econometric tests of models, which is particularly well-suited to reduce the number of variables in a data set by extracting meaningful linear combinations from the observed variables that may concur to explain a given phenomenon (the dependent variable). These combinations, called “common factors”, can be interpreted as latent, non-observable variables.
Rating sovereign debt in a monetary union – original sin by transnational governance
Authors: Körner Finn Marten , Trautwein Hans-Michael 
Published: June 2015

Purpose
– The purpose of this paper is to test the hypothesis that major credit rating agencies (CRAs) have been inconsistent in assessing the implications of monetary union membership for sovereign risks. It is frequently argued that CRAs have acted procyclically in their rating of sovereign debt in the European Monetary Union (EMU), underestimating sovereign risk in the early years and over-rating the lack of national monetary sovereignty since the onset of the Eurozone debt crisis. Yet, there is little direct evidence for this so far. While CRAs are quite explicit about their risk assessments concerning public debt that is denominated in foreign currency, the same cannot be said about their treatment of sovereign debt issued in the currency of a monetary union.

Design/methodology/approach
– While CRAs are quite explicit about their risk assessments concerning public debt that is denominated in foreign currency, the same cannot be said about their treatment of sovereign debt issued in the currency of a monetary union. This paper examines the major CRAs’ methodologies for rating sovereign debt and test their sovereign credit ratings for a monetary union bonus in good times and a malus, akin to the “original sin” problem of emerging market countries, in bad times.

Findings
– Using a newly compiled dataset of quarterly sovereign bond ratings from 1990 until 2012, the panel regression estimation results find strong evidence that EMU countries received a rating bonus on euro-denominated debt before the European debt crisis and a large penalty after 2010.

Practical implications
– The crisis has brought to light that EMU countries’ euro-denominated debt may not be considered as local currency debt from a rating perspective after all.

Originality/value
– In addition to quantifying the local currency bonus and malus, this paper shows the fundamental problem of rating sovereign debt of monetary union members and provide approaches to estimating it over time.
Does commitment to environmental self-regulation matter? An empirical examination from China
Authors: Lin Han , Zeng Saixing , Ma Hanyang , Chen Hongquan 
Published: June 2015

Purpose– The purpose of this paper is to develop a better understanding of the mechanisms by which symbolic commitment to self-regulation influences corporate environmental performance through the adoption of substantive actions.Design/methodology/approach– Using a sample of Chinese listed private firms in manufacturing sectors, this paper empirically investigates whether and how corporate symbolic commitment to environmental self-regulation really improves the consequences of corporate activities with respect to environmental issues under the current Chinese context. A moderated mediation analysis is employed to test the hypotheses and examine the relationships proposed in the research framework.Findings– The authors argue that making a commitment to environmental self-regulation could motivate firms to implement effective means of being green. The intriguing and robust results show that firms with higher ranking environmental commitment are more likely to use political connections to obtain resources (green subsidies), and then improve environmental performance.Practical implications– The results of this study provide a snapshot of the mechanism between symbolic promises and real outcomes.Originality/value– The authors theorize about and test both direct and indirect effects of commitment to self-regulation on real outcomes which provide empirical evidence for the incipient but growing understanding of self-regulation.
The effect of cold-pressing and solvent extraction on some characteristics of kariya (Hildergadia barteri) seed oil
Authors: Adebayo Adewale Williams , Ogunsina Babatunde S , Gbadamosi Olasunkanmi Saka 
Published: June 2015

Purpose
– This study aims to investigate some physicochemical characteristics of Hildegardia barteri seed oils obtained by cold-pressing and solvent extraction procedures.

Design/methodology/approach
– Crude oil samples were obtained from the kernels by cold pressing and solvent extraction. The physicochemical properties of the oil samples were investigated according to the standard procedures in published works of literature.

Findings
– The oil yield was 55.7 and 97 per cent for cold-pressed kariya seed oil (CPKSO) and solvent-extracted kariya seed oil (SEKSO), respectively. Specific gravities, refractive indices, viscosities, iodine value, saponification value, peroxide value and acid value were 0.8742 and 0.9036; 1.4629 and 1.4584; 75.93 and 74.90 mPa.s; 55.78 and 53.56 g of I2/100g of oil; 249.76 and 253.90 mg KOH/g; 4.86 and 5.02 meq KOH/g; 2.12 and 2.09 mg KOH/g of oil for CPKSO and SEKSO, respectively. The physicochemical characteristics of kariya seed oil were not significantly affected by extraction method. The fatty acid profiles of CPKSO and SEKSO showed that the two oil samples contain 24.2 and 23.7, 31.3 and 29.3, 23.2 and 23.7 and 19.6 and 21.3 per cent of myristic, palmitic, stearic and linolenic acids, respectively. Lauric and oleic acids were present in very little proportions of 0.3 and 0.41; and 0.01 and 0.03 per cent, respectively, whereas linoleic acid was 1.4 per cent for the two oil samples. Significant differences in fatty acid profiles were observed for lauric, palmitic and linolenic acids (p = 0.05). Saturated and unsaturated fatty acids were about 79.0 and 77.11 per cent and 21.01 and 22.73 per cent for CPKSO and SEKSO, respectively.

Practical implications
– This work promotes H. barteri tree beyond its use as a mere ornamental plant. The non-conventional seed oil it produces may find relevance in the food or biofuels industry subject to further investigation.

Originality/value
– This study is the first to document the extraction and physicochemical properties of kariya seed oils.
Accelerated maturation of processed yerba-mate under the controlled conditions of temperature and humidity
Authors: Gonçalves Itamar Luís , Dartora Nessana , Piovezan Borges Ana Cláudia , Picolo Ana Paula , Dallago Rogério Marcos , Mera de Souza Lauro , Valduga Alice Teresa 
Published: June 2015

Purpose
– The purpose of this paper was to assess the changes in secondary metabolites and color during yerba-mate aging under controlled conditions. In Uruguay and Paraguay, the yerba-mate matured, in which chlorophyll degradation occurs, is preferred. For the matured product, the yerba-mate is stored for six months to one year.

Design/methodology/approach
– Processed yerba-mate was submitted to 35°C and 80 per cent humidity during 42 days in a climatic chamber. Samples were collected every seven days, and the phenolic compounds/methylxanthines were quantified by ultra-performance liquid chromatography – photodiode array and chlorophylls/phaeophytins by spectrophotometry. L*, a* and b* colorimetric coordinates were measured.

Findings
– The most expressive changes in the color occur in the first 14 days. At this time, 23.161 ± 2.984 per cent of total chlorophyll was degraded, considering that in 42 days, 37.458 ± 0.955 per cent is degraded, according to an exponential model. A positive correlation between theobromine amount and maturation time was found. This was verified by an increase in dicaffeoylquinic acid concentrations and small changes in chlorogenic acid isomers.

Practical implications
– The results indicate that this is a viable accelerated yerba-mate maturation process according to economics and nutraceutics.

Originality/value
– The paper has reported here a novel strategy to promote the yerba-mate maturation using controlled conditions.