bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Role of IL-6 in the Pathogenesis of Systemic Lupus Erythematosus: Insights from Bone Marrow Mesenchymal Stem Cells
Authors: Zhang Zhiwen , Zhu Sillang , Li Qian , Wei Shanshan , Yin Li , Zhu Junhao , Yang Shan , Zhang Wenjing , Lai Kuan 
Published: August 2024

Abstract

Systemic lupus erythematosus is a common autoimmune disease. Studies have suggested that defective stem cells could be involved in the pathogenesis of systemic lupus erythematosus, which leads to changes in the function of immune cells. By observing the cell morphology, autophagy, and senescence of bone marrow mesenchymal stem cells (BMSCs) from lupus mice and normal controls, this study investigated the role of IL-6 in autophagy and senescence of BMSCs and explored relevant mechanisms. Female MRL/lpr and C57 mice with similar weights and sizes at 20–22 weeks old were selected. BMSCs were isolated using the whole bone marrow adherent method. Quantitative real-time polymerase chain reaction, β-galactosidase staining, western blotting, and ELISA were used to detect autophagy and senescence. Compared with BMSCs from normal mice, BMSCs from lupus mice exhibited low autophagy and premature senescence with a senescence-associated secretory phenotype. The addition of exogenous IL-6 increased the protein levels of p-STAT3 and Bcl-2, and in the IL-6-treated group, the premature senescence of cells increased and autophagy decreased. The biological functions of BMSCs from MRL/lpr lupus mice were impaired. IL-6 prevents autophagy and subsequently promotes the senescence of BMSCs by activating the IL-6/STAT3 pathway.
Neoantigen evolution and response to checkpoint inhibitor immunotherapy in colorectal cancer
Authors: Bozic Ivana , Sholokova Alanna , Kaveh Kamran 
Published: August 2024

Abstract

Checkpoint-blockade immunotherapy enables the patient’s immune system to recognize tumor cells that were previously invisible due to immune escape, but these therapies lead to heterogeneous patient outcomes. Focusing on colorectal cancer, in which two subtypes have markedly different responses to immunotherapy, we seek to understand how the mutagenic landscape of the tumor is related to therapeutic outcomes. First, we model neoantigen evolution in growing tumors using a stochastic branching-process model. Neoantigenic peptide sequences arising from colorectal cancer patient data are scored for fitness, giving each in-silico tumor a unique pre-treatment mutational landscape. Next, we use a dynamical systems model of the tumor-immune interaction under checkpoint-blockade therapy, optimized by fitting clinical trial data to model outcomes, to simulate therapeutic trajectories. We relate therapeutic outcomes to the heterogeneity of tumor mutational landscape, quantified by the number of mutations in the tumor, the immunogenicity of these mutations, and the clonality of the neoantigens present in the tumor. A high mutation burden, as well as the presence of highly fit neoantigens, are not sufficient to determine a successful response to therapy; conversely, the presence of a strong clonal neoantigen, present in every cell of the tumor, appears crucial for a successful response to therapy.
The Dynamics and Role of Sufism in Turkish Politics and Society
Authors: Darmaiza Darmaiza , Meirison Meirison , Rusli Ayu Rustriana , Muhammadi Qasim 
Published: August 2024

Sufism is widespread in Turkey, and most Turkish people sympathise with the Sufis even if they do not adhere to particular Sufi orders. Sufism has been rooted in Turkish society throughout history and has experienced ups and downs. This article is a literature study that used a qualitative approach and descriptive analysis. Data were collected from documents, literature, and journals. This study found that Sufism was not entirely swept up by secularisation, particularly in rural areas. Even in urban areas, many still adhere to Islamic traditions, including Sufism, passed down from generation to generation. Furthermore, Sufism influenced the political world in Turkey and the period preceding the Ottoman Empire's collapse. Even after that, a new pattern of Sufism emerged, namely Sufism without order, which resulted from understanding the Risale-i Nur, written by Said Nursi. Contribution: This article is expected to explain the role of Sufism in Turkey during the classical period as an agent of moderate Islam propagation who built a spirit of struggle. This study shows that Sufism in Turkey has different understandings from others that distance themselves from political matters, social activities, and state affairs.
The Sufi Poems of Love: Al Busiri’s Burdah through The Lens of Rumi
Authors: Arikhah Arikhah 
Published: August 2024

Examining the Maḥabbah concept has unavoidably become an interesting study, particularly via tasawuf lenses. Maḥabbah is a spiritual phase that Sufis encounter in many forms and expressions. Many Sufi leaders documented their experiences in literary works, including al-Busiri’s Burdah poems. A work that is regarded to be high literature consists of compliments to the Prophet Muhammad Saw. The purpose of this study is to discuss the Maḥabbah literature of al-Busiri’s Burdah and how the school of love is internalized in his work, where both concerns are examined through Rūmī's literary conceptions that highlight the Maḥabbah as the means of his tasawuf characteristic. This paper is qualitative library research. This study revealed that the Burdah of al-Busiri matches Jalāluddīn Rūmī's expression, which used metaphors, symbolization of love, and the conception of Maḥabbah.Contribution: By investigating Jalāluddīn Rūmī's notion, this study provides understanding and showing the Maḥabbah values found in al-Busiri's Burdah poems while also illuminating features of the historicity of tasawuf around it.
LINC00651, A Long Non-Coding RNA, Acts as a Catalyst in the Progression of Breast Cancer by Promoting Proliferation, Migration, and Invasion
Authors: Bhandari Adheesh , Hirachan Suzita , Kong Lingguo 
Published: August 2024

Introduction:
The incidence of Breast Cancer (BC), a prevalent malignancy
in women, has gone up recently, although the molecular pathways underlying the carcinogenesis
of BC are still unknown. Long non-coding RNAs (lncRNAs) have become
important tumor progression regulators.

Method:
The present study has revealed increased expression of LINC00651 in BC tissues
through a thorough investigation of whole-transcriptome resequencing on matched
BC and normal tissues from 8 patients. It is yet unknown precisely as to what biological
function LINC00651 serves in BC.
To obtain further insight, 39 matched pairs of breast tumors and normal tissues underwent
Real-time quantitative Polymerase Chain Reaction (RT-qPCR) for validation. The
validated cohort's clinicopathologic characteristics were then carefully examined. Following
short interfering RNA transfection, proliferation, colony formation, migration, invasion,
and examination of phenotypes associated with the Epithelial-mesenchymal
Transition (EMT) were conducted in BC cell lines (MDA-MB-231 and BT-549).

Results:
Our findings have confirmed that LINC00651 plays a role in augmenting BC
cell lines' proliferation, migration, and invasion. Consequently, LINC00651 can be considered
a potential new therapeutic target for BC treatment.

Conclusion:
As breast cancer remains a significant health concern, understanding its
molecular underpinnings is crucial for developing effective treatments. The identification
of LINC00651 as a promoter of BC cell growth and metastasis has suggested that it
could be a promising target for future therapeutic interventions, potentially offering new
avenues for improved patient outcomes.
Impact of the COVID-19 Pandemic on Influenza Hospital Admissions and Deaths in Wales: Descriptive National Time Series Analysis
Authors: Alsallakh Mohammad , Adeloye Davies , Vasileiou Eleftheria , Sivakumaran Shanya , Akbari Ashley , Lyons Ronan A , Robertson Chris , Rudan Igor , Davies Gwyneth A , Sheikh Aziz 
Published: August 2024

Abstract

Background
The COVID-19 pandemic and the ensuing implementation of control measures caused widespread societal disruption. These disruptions may also have affected community transmission and seasonal circulation patterns of endemic respiratory viruses.

Objective
We aimed to investigate the impact of COVID-19–related disruption on influenza-related emergency hospital admissions and deaths in Wales in the first 2 years of the pandemic.

Methods
A descriptive analysis of influenza activity was conducted using anonymized pathology, hospitalization, and mortality data from the Secure Anonymised Information Linkage Databank in Wales. The annual incidence of emergency hospitalizations and deaths with influenza-specific diagnosis codes between January 1, 2015, and December 31, 2021, was estimated. Case definitions of emergency hospitalization and death required laboratory confirmation with a polymerase chain reaction test. Trends of admissions and deaths were analyzed monthly and yearly. We conducted 2 sensitivity analyses by extending case definitions to include acute respiratory illnesses with a positive influenza test and by limiting admissions to those with influenza as the primary diagnosis. We also examined yearly influenza testing trends to understand changes in testing behavior during the pandemic.

Results
We studied a population of 3,235,883 Welsh residents in 2020 with a median age of 42.5 (IQR 22.9–61.0) years. Influenza testing in Wales increased notably in the last 2 months of 2020, and particularly in 2021 to 39,720 per 100,000 people, compared to the prepandemic levels (1343 in 2019). The percentage of influenza admissions matched to an influenza polymerase chain reaction test increased from 74.8% (1890/2526) in 2019 to 85.2% (98/115) in 2021. However, admissions with a positive test per 100,000 population decreased from 17.0 in 2019 to 2.7 and 0.6 in 2020 and 2021, respectively. Similarly, deaths due to influenza with a positive influenza test per 100,000 population decreased from 0.4 in 2019 to 0.0 in 2020 and 2021. Sensitivity analyses showed similar patterns of decreasing influenza admissions and deaths in the first 2 years of the COVID-19 pandemic.

Conclusions
Nonpharmaceutical interventions to control COVID-19 were associated with a substantial reduction in the transmission of the influenza virus, with associated substantial reductions in hospital cases and deaths observed. Beyond the pandemic context, consideration should be given to the role of nonpharmaceutical community-driven interventions to reduce the burden of influenza.
Does Discussing Audit Procedures in Critical Audit Matter Calibrate Financial Reporting Risk Assessments?
Authors: Boo El’fred , Low Kin Yew , Shankar Premila Gowri , Tan Hun-Tong 
Published: August 2024

SYNOPSIS
We examine in a controlled experiment whether discussing audit procedures that address a complex investment valuation issue in the critical audit matter (CAM) paragraph of the auditor’s report calibrates sophisticated users’ financial reporting risk (FRR) assessments. Our findings support this calibrating effect, that is, minimizing shifts in their risk assessments before versus after the realization of the risk event (i.e., a significant decline in the fair value of investments pre-empted earlier in the CAM disclosures). Minimizing large swings in users’ risk perceptions is an important consideration to the profession to minimize negative surprises and audit litigation. Our results support standard-setters’ views that discussing audit procedures in the CAM disclosures is value adding in calibrating sophisticated users’ FRR assessments.
Data Availability: Data are available from the authors on request.
JEL Classifications: D81; M42.
Extracting Financial Data from Unstructured Sources: Leveraging Large Language Models
Authors: Li Huaxia , Gao Haoyun , Wu Chengzhang , Vasarhelyi Miklos A. 
Published: August 2024

ABSTRACT
This research addresses the challenge of extracting financial data from unstructured sources, a persistent issue for accounting researchers, investors, and regulators. Leveraging large language models (LLMs), this study introduces a novel framework for automated financial data extraction from Portable Document Format (PDF)-formatted files. Following a design science methodology, this research develops the framework through a combination of text mining and prompt engineering techniques. The framework is subsequently applied to analyze governmental annual reports and corporate environmental, social, and governance reports, which are presented in PDF format. Test results indicate that the framework achieves an average 99.5 percent accuracy rate in a notably short time span when extracting key financial indicators. A subsequent large out-of-sample test reveals an overall accuracy rate converging around 96 percent. This study contributes to the evolving literature on applying LLMs in accounting and offers a valuable tool for both academic and industrial applications.
Data Availability: Data are available upon request.
JEL Classifications: M41; O31; C81.
Stability of Pure Biodiesel (B100), Biodiesel Mixture (B40), and Petroleum Diesel (B0) Due to Storage
Authors: Mufidah Zunanik , Tiguna Amril Hakim , Haryanto Agus 
Published: August 2024

Biodiesel is produced from synthetic ester compounds of vegetable and animal oils through a process of refining, bleaching, degumming, transesterification, and esterification. The quality and characteristics of the fuel are greatly influenced by the storage. The purpose of this research is to determine and analyze the effect of storage conditions on the physical and chemical changes of biodiesel (B100), biodiesel blend (B40), and petro diesel (B0). Experiment was conducted by storage fuels using glass bottle for 35 days arranged into four conditions based on cap and wrapping using aluminum foil, namely P1 (with cap, with wrapping), P2 (with cap, no wrapping), P3 (no cap, with wrapping), and P4 (no cap, no wrapping). Results showed that fuel quality decreases due to storage indicated by an increase in water content, density, acid number, and color parameters, as well as a decrease in the specific calorific value of all fuels. The condition of the storage container affected the changes the quality parameters. Based on its impact on fuel quality decline, the order of storage container conditions from the best is P1 (with cap, with wrap) > P2 (with cap, no wrap) > P3 (no cap, with wrap) > P4 (no cap, no wrap). Keywords: Biodiesel, Biodiesel blend (B40), Diesel fuel, Stability, Storage time.
The Legal Power in Evidence of Electronic Medical Records As A Substitute for A Doctor's Signature
Authors: Widjaja Christine , Adriano Adriano 
Published: August 2024

The existence of related regulations regarding validity of Electronic Medical Record (EMR) in proving a case explained that it requires a signature in proving an EMR. The use of a personal identification number (PIN) only performs a verification function, not someone's authentication.UU No. 29 of 2004 regarding Medical Practice states that it is sufficient to replace the obligation to sign an EMR with a Personal Identification Number (PIN), while in Permenkes Medical Records 2022, it is expanded by granting access rights to certain people where the security system depends on the decision of the leadership of each health care facility and can be equipped with an Electronic Signature. The use of a PIN alone is considered insufficient form EMR authentication functions, so other options need to be raised such as Electronic Signature which carry out both verification and authentication functions. The aims of research were to find out how the legality and strength of evidence of PIN and Electronic Signature as substitution of doctor’s signature on electronic medical records. This study used a normative juridical method, with two approaches, namely statutory and conceptual approaches. The results showed that PIN and Electronic Signature could legally replace a doctor’s signature on EMR, but hada different strength as evidence. The strength of EMR as evidence depends on the judge’s point of view which is influenced by validity of EMR evidence, namely the presence/absence of a PIN and electronic signature as a function of verification and authentication.
Optimalisasi Penggunaan Alat Car Battery Tester Dan Tire Depth Gauge
Authors: Sabil Loisa Gelaro , Tyagita Dicky Adi , Irawan Andik 
Published: August 2024

Auto2000 Denpasar, yang terletak di Jl. HOS Cokroaminoto, Ubung, 81, Denpasar, Bali, merupakan perusahaan yang menyediakan peluang magang bagi siswa dan mahasiswa. Fokus usaha perusahaan ini mencakup pelayanan jasa penjualan, perawatan, perbaikan, dan penyediaan suku cadang Toyota, dengan manajemennya ditangani sepenuhnya oleh PT Astra Internasional Tbk. Permasalahan yang dihadapi di Auto2000 Denpasar adalah kekurangan alat Car Battery Tester dan Tire Depth Gauge, yang mengakibatkan mekanik harus bergantian menggunakan peralatan tersebut. Hal ini menyebabkan penurunan efisiensi kinerja mekanik serta meningkatkan risiko kerusakan dan kehilangan alat. Untuk mengatasi masalah ini, solusi yang diusulkan adalah mengoptimalkan penggunaan kedua alat tersebut dengan membentuk divisi petugas checker aki dan ban. Divisi ini akan bertanggung jawab untuk melakukan pengecekan kondisi aki dan ban mobil sebelum memasuki stall servis. Petugas checker aki dan ban dapat direkrut dari siswa atau mahasiswa yang sedang menjalani magang di Auto2000 Denpasar. Dengan pembentukan divisi ini, penggunaan alat dapat terpusat, terjadwal, dan waktu kerja mekanik menjadi lebih efisien.
Counseling on Elderly about Gymnastics to Improve Sleep Quality of The Elderly
Authors: Handayani Endah Purwanti , Lestari Susi , Astutik Eftyaningrum Dwi Wahyu , Lestari Tiyan Febriyani , Vitania Wiwit , Putri Harlinda Widia , Hasnia  , Pratami Yustika Rahmawati , Saldianti Siti , Apaseray Yuliana Antoneta , Daap Silpa , Amyol Emeliana , Karoba Senita , Mallo Anice , Kwano Welmince 
Published: August 2024

Elderly (elderly) is the final stage of development in the human life cycle which is a natural process that cannot be avoided, runs continuously, and continuously. As they get older, the elderly certainly experiences changes physically, psychologically, socially and spiritually. The cause of these changes can interfere with sleep quality. The level of physical ability that has decreased is very influential on the quality of sleep of the elderly. The purpose of this community service was to convey important information to maintain health for the elderly by routinely carrying out sports such as elderly gymnastics, so that the elderly can carry out normal activities. The method was counseling for the population group of all elderly at the Sereh Village Posyandu as many as 32 people. The result showed that there was an increase in knowledge about the elderly.
EFEKTIFITAS PENDAMPINGAN KELUARGA UNTUK MENURUNKAN ANGKA STUNTING
Authors: Isyti'aroh I , Aktifah Nurul , Rofiqoh Siti , Nurseptiani Dzikra , Islamudin Ma'ruf , Fadhilah Nia Imatul 
Published: August 2024

Stunting adalah keadaan tinggi badan anak lebih rendah jika dibandingkan dengan umur. Stunting mempunyai dampak negatif bagi tumbuh kembang anak sehingga perlu penanganan agar tumbuh kembang anak optimal. Tujuan penelitian ini adalah untuk mengetahui efektifitas pendampingan keluarga dalam menurunkan angka stunting. Metoda penelitian ini menggunakan desain one group pretest and posttest design. Intervensi yang dilakukan adalah pendampingan keluarga dengan mengedukasi keluarga dan mendampingi penyelesaian masalah berdasarkan masalah yang ditemui. Teknik pengambilan sampel dengan cluster sampling pada 20% (3 desa) dari 11 desa yang ada di wilayah kerja puskesmas Buaran Pekalongan. Jumlah total responden sebanyak 27 keluarga. Instrumen penelitian menggunakan lembar observasi pengukuran tinggi badan disesuaikan umur dan angket data demografi keluarga. Hasil penelitian karakteristik demongrafi menunjukkan 52% ibu tingkat pendidikannya dasar dan ayah 56%. Pekerjaan ibu 67% ibu rumah tangga, pekerjaan ayah 74% buruh. Analisis kerutinan ke posyandu menunjukkan 81% rutin ke posyandu. Hasil analisis efektiitas intervensi terhadap penurunan status stunting menunjukkan perubahan stunting menjadi tidak stunting sebanyak 30% dan penurunan prosentasi dari sangat pendek menjadi pendek sebesar 16%. p value didapatkan 0,003. Kesimpulan penelitian adalah pendampingan keluarga efektif menurunkan angka stunting. Disarankan agar penanganan stunting melalui pendekatan komprehensif terutama pada keluarga berdasarkan masalah yang ditemui keluarga
Economic efficiency of domestic tomato varieties production with the use of biopreparations
Authors: Akhmedova P. M. 
Published: August 2024

The results of domestic tomato varieties testing with application of growth biostimulant on plant productivity in open ground conditions of the Tersko-Sulak subprovince of Dagestan are presented. The purpose of the research was to study new domestic tomato varieties of the Federal Research Center for Vegetable Growing (FRC VG) selection and to assess the economic efficiency of the application of biopreparation Relict R (liquid). New domestic tomato varieties, bred by scientists-breeders of the Federal Research Center for Vegetable Growing for risky farming zones, in the conditions of southern Russia have shown quite high results on the main economically valuable indicators. Relict R, a preparation based on salts of humic and fulvic acids with growth-stimulating, adaptogenic and protective properties for a wide range of crops, was applied at the plantings. The preparation was developed at the Siberian Branch of the Russian Academy of Sciences. The manufacturing company was OOO RPE “Genesis” (Russia). Tomatoes were grown according to generally accepted technology under open ground conditions. All varieties were early maturing with a growing season duration of 93–110 days. Voskhod VNIISSOK, Blagodatny and Sodruzhestvo varieties showed the best yields (85.3; 83.6 and 78.2 t/ha). All varieties were also distinguished by high early yields (24.2–42.5 t/ha). Dry matter content ranged from 4.1 to 6.9%. The best varieties were Viking, Sodruzhestvo, and Blagodatny, with indexes of 15.2; 13.1; and 8.2, respectively. The ascorbic acid content ranged from 24.85 to 45.20mg%. The Viking variety was distinguished by high content of vitamin C (45.20mg%), as well as vitamins B1, B2, B6, B5 (0.074; 0.058; 0.083; 0.258 mg%). The Magnat variety stood out for the highest content of vitamin B3 (0.511 mg%). Application of the biopreparation significantly increased the yield compared to the control (by 4.1 t/ha), it was higher than the planned yield (80 t/ha). Tomato yield when using Relict R was 85.3 t/ha. The use of biopreparation provided a high positive economic effect – net income and profitability level were higher when using Relict R and amounted to 3928.5 thousand rubles/ha and 12%, respectively. According to the results of the research it is recommended to use humic preparation Relict R (liquid) on tomatoes to increase yield and quality indicators in the conditions of the south of the country.