bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment the Impact of IDH Mutation Status on MRI Assessments of White Matter Integrity in Glioma Patients: Insights From Peak Width of Skeletonized Mean Diffusivity and Free Water Metrics
Authors: Li Yuanhao , Zhu Hongquan , Liu Yufei , Ding Yujie , Li Shihui , Li Li , Zhang Jiaxuan , Jiang Jingjing , Shen Nanxi , Zhu Wenzhen 
Published: August 2024

BackgroundGliomas are highly invasive brain tumors that evade accurate geographic assessment by conventional MRI due to microscopic invasion along white matter (WM) tracts. Advanced diffusion MRI techniques are needed to assess occult WM involvement.PurposeTo evaluate peak width of skeletonized mean diffusivity (PSMD) and peak width of skeletonized free water (PSFW), and axonal water fraction (AWF) for assessing glioma‐induced alterations in normal‐appearing WM and their relationship with isocitrate dehydrogenase 1 (IDH1) mutation.Study TypeRetrospective.PopulationOne hundred five glioma patients (46 ± 13 years), 53 healthy controls (HCs) (46 ± 9 years).Field Strength/Sequence3.0 T, T1WI, T1‐CE, T2WI, T2FLAIR, and DKI.AssessmentPSMD and PSFW were compared between lesion and contralateral sides in glioma patients and between patients and HCs. The associations between these metrics and clinical variables, including IDH1 mutation, was assessed. Corpus callosum (CC) injury, quantified by the AWF, was evaluated for its mediated effect of IDH1 mutation on contralesional PSMD and PSFW.Statistical TestsPaired‐t tests, ANCOVA, univariate and multivariate linear regression, and mediation analysis with significance set at P < 0.05.ResultsContralateral PSMD and PSFW were significantly higher in left‐sided gliomas (PSMD: 0.206 ± 0.027 vs. 0.193 ± 0.023; PSFW: 0.119 ± 0.019 vs. 0.106 ± 0.020) than in HCs, with similar increases in right‐sided gliomas (PSMD: 0.219 ± 0.036 vs. 0.195 ± 0.023; PSFW: 0.129 ± 0.031 vs. 0.109 ± 0.020). IDH1 wild‐type gliomas were associated with higher contralateral PSMD and PSFW (β = −0.302 and −0.412). AWF of CC mediated the impact of IDH1 mutations on contralesional PSMD and PSFW (mediated proportion: 42.7% and 53.7%).Data ConclusionPSMD and PSFW are effective biomarkers for assessing WM integrity in gliomas, significantly associated with IDH1 mutation status. AWF of CC mediates the relationship between IDH1 mutation and contralesional PSMD and PSFW.Evidence Level4Technical EfficacyStage 2
Multiparametric MRI‐Based Deep Learning Radiomics Model for Assessing 5‐Year Recurrence Risk in Non‐Muscle Invasive Bladder Cancer
Authors: Huang Haolin , Huang Yiping , Kaggie Joshua D. , Cai Qian , Yang Peng , Wei Jie , Wang Lijuan , Guo Yan , Lu Hongbing , Wang Huanjun , Xu Xiaopan 
Published: August 2024

BackgroundAccurately assessing 5‐year recurrence rates is crucial for managing non‐muscle‐invasive bladder carcinoma (NMIBC). However, the European Organization for Research and Treatment of Cancer (EORTC) model exhibits poor performance.PurposeTo investigate whether integrating multiparametric MRI (mp‐MRI) with clinical factors improves NMIBC 5‐year recurrence risk assessment.Study TypeRetrospective.PopulationOne hundred ninety‐one patients (median age, 65 years; age range, 54–73 years; 27 females) underwent mp‐MRI between 2011 and 2017, and received ≥5‐year follow‐ups. They were divided into a training cohort (N = 115) and validation/testing cohorts (N = 38 in each). Recurrence rates were 23.5% (27/115) in the training cohort and 23.7% (9/38) in both validation and testing cohorts.Field Strength/Sequence3‐T, fast spin echo T2‐weighted imaging (T2WI), single‐shot echo planar diffusion‐weighted imaging (DWI), and volumetric spoiled gradient echo dynamic contrast‐enhanced (DCE) sequences.AssessmentRadiomics and deep learning (DL) features were extracted from the combined region of interest (cROI) including intratumoral and peritumoral areas on mp‐MRI. Four models were developed, including clinical, cROI‐based radiomics, DL, and clinical‐radiomics‐DL (CRDL) models.Statistical TestsStudent's t‐tests, DeLong's tests with Bonferroni correction, receiver operating characteristics with the area under the curves (AUCs), Cox proportional hazard analyses, Kaplan–Meier plots, SHapley Additive ExPlanations (SHAP) values, and Akaike information criterion for clinical usefulness. A P‐value <0.05 was considered statistically significant.ResultsThe cROI‐based CRDL model showed superior performance (AUC 0.909; 95% CI: 0.792–0.985) compared to other models in the testing cohort for assessing 5‐year recurrence in NMIBC. It achieved the highest Harrell's concordance index (0.804; 95% CI: 0.749–0.859) for estimating recurrence‐free survival. SHAP analysis further highlighted the substantial role (22%) of the radiomics features in NMIBC recurrence assessment.Data ConclusionIntegrating cROI‐based radiomics and DL features from preoperative mp‐MRI with clinical factors could improve 5‐year recurrence risk assessment in NMIBC.Evidence Level3Technical EfficacyStage 3
The Effects of Service Recovery Actions on Customers' Post‐Recovery Responses to Online Travel Agencies (OTAs): The Moderating Role of Price
Authors: Hwang Jungjin 
Published: August 2024

ABSTRACTThe main purpose of this study is to investigate the impacts of service recovery actions on customers' post‐recovery responses to initial service failure and a double deviation and to investigate the moderating effect of price on the relationship between recovery actions and these responses. The findings show that active recovery actions led to more favorable post‐recovery responses than passive actions in both initial and double deviation situations. No moderating effect of price was found between recovery actions and customers' post‐recovery responses. From an academic perspective, this study helps researchers understand how customers positively perceive recovery actions that reflect procedural and interactional justice in service failure situations. The findings also suggest that practitioners of OTAs should engage in active recovery actions that include prompt communication on the progress of the incident (i.e., procedural justice) and a sincere apology (interactional justice) to alleviate customers' negative responses due to service failures.
Ethanol Extract of Propolis Attenuates Liver Lipid Metabolism Disorder in High‐Fat Diet‐Fed SAMP8 Mice
Authors: Xie Quan‐yuan , Shu Xin , Liu Tao , Chen Li‐li , Luo Li‐ping 
Published: August 2024

ScopeThe prevalence of high‐fat diet (HFD) consumption is increasing among middle‐aged and older adults, which accelerates the aging process of this population and is more likely to induce lipid metabolism disorders. But the alleviation of ethanolic extract of propolis (EEP) on lipid metabolism disorders during aging remains unclear.Methods and resultsThis study assesseed the impact of EEP intervention (200 mg kg−1 bw) on aging and lipid metabolism disorders in HFD‐fed senescence accelerate mouse prone 8 (SAMP8) mice. Findings indicate that EEP ameliorates hair luster degradation and weight gain, reduces systemic inflammation and metabolism levels, enhances hepatic antioxidant enzyme activities, and improves the hepatic expression of senescence‐associated secretory phenotype and aging‐related genes in HFD‐fed SAMP8 mice. Histological staining demonstrates that EEP improves hepatic lipid deposition and inflammatory cell infiltration. Transcriptomic and lipidomic analysis reveal that EEP promotes fatty acid β‐oxidation by activating PPAR pathway, resulting in reduced hepatic lipid deposition, and attenuates bile acid (BA) accumulation by improving BA metabolism, which were ensured through qPCR validation of key genes and immunoblot validation of key proteins.Conclusions EEP can regulate lipid metabolic dysregulation during aging accompanied by an HFD, potentially delaying the onset and progression of age‐related diseases. This provides new approach for supporting healthy aging.
Students' core competence performance during fundamental nursing practicum: A cross‐sectional survey with importance–performance analysis
Authors: Chang Yu‐Hsuan , Shun Shiow‐Ching , Lin Pao‐Chen 
Published: August 2024

AbstractAimLimited available studies compare the core competence performance of students undertaking their practicum at different level‐of‐care practicum sites. This study aimed to (1) compare the gaps between the perception of importance for competence and the perceived performance of nursing students at practicum sites involving different level‐of‐care and (2) identify low competencies that must be prioritized for improvement at different sites during the fundamental nursing practicum.DesignCross‐sectional design.MethodsA total of 659 students who had passed their fundamental nursing practicum within 1 month from six nursing colleges in Taiwan were recruited. The students completed the 25‐item Core Competence in Fundamental Nursing Practicum Scale, wherein both the importance and performance level of each item are indicated. One‐way analysis of variance along with the Scheffe post hoc test and importance–performance analysis were used to explore the gaps between the perception of importance for competence and the perceived performance and to identify weak competencies that must be prioritized for improvement, respectively.ResultsCompared with nursing students practicing in district hospitals (predominantly caring for chronically ill patients), nursing students practicing in medical centres (predominantly caring for patients with severe and critical conditions) had larger gaps in total scores and the application of nursing processes. Students in medical centres also had larger gaps in professional attitude than their counterparts in long‐term care facilities. Importance–performance analysis identified a common shortfall in communication skills among nursing students for all level‐of‐care practicum sites. Students at long‐term facilities had the highest number of weak competencies that required improvement. The results of this study can guide instructors in designing curricular activities focused on the weaker core competencies of the students at a practicum site for each level of care.Patient or Public ContributionNo patient or public contributions.
Synthesis of azabenzotriazole‐terminated liquid crystal poly(ester imide)s for improving their adhesion to copper foils
Authors: Li Xiangyi , Guo Yuanqin , Liu Shumei , Zhao Jianqing 
Published: August 2024

AbstractLiquid crystal polymers (LCPs) should be widely used as substrates in flexible copper clad laminate (FCCL) owing to their unique advantages. However, the poor adhesion of LCPs to copper foils hinders their applications. Considering the good adhesion between polyimides and copper foils, imide groups have previously been introduced into the main chains of LCP molecules. In the present paper, to further enhance the adhesion of the LCPEIs, the 1‐hydroxy‐7‐azabenzotriazole (HOAt) is used to terminate the main chains of LCPEI molecules, which arises from the excellent coordination interaction between the azabenzotriazole groups and copper ions. Thus, the liquid crystal poly(ester imide) (t‐LCPEI), carboxyl‐terminated liquid crystal poly(ester imide) (c‐LCPEI), and azabenzotriazole‐terminated liquid crystal poly(ester imide) (a‐LCPEI) were synthesized. The results showed that LCPEIs possessed liquid crystallinity, and the peel strength of a‐LCPEI film to copper foils was increased by about 140% and nearly 43%, respectively, compared to that of LCP and t‐LCPEI. Moreover, a‐LCPEI showed higher glass transition temperature (Tg = 211°C) than conventional LCP resins (Tg = 155°C, Vectra A), and excellent thermal properties. Meanwhile, the dielectric constant and loss of a‐LCPEI were as low as 3.04 and 9.7 × 10−3 at 10 GHz, respectively. These findings indicate that the azabenzotriazole‐terminated LCPEI is suitable to be used as the substrate material for high‐performance FCCL, and the work provides a feasible approach to enhance the adhesion and maintain the other outstanding properties of LCP.
Evaluation of fatigue characteristics of 3D printed/composites reinforced with carbon fiber using design of experiments
Authors: Jamadar Imran M. , Kamate Pavankumara , Samal Prasanta Kumar 
Published: August 2024

AbstractThis study investigates the fatigue characteristics of 3D‐printed composites made from polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS), reinforced with carbon fiber. It involves designing and building a rotating bending fatigue machine, creating standard specimens via FDM, and applying DOE using Taguchi method. Standard specimens are subjected to cyclic loading with a print orientation of 0°, 45°/−45°, and 90°, motor speed and load. Materials such as PLA, ABS, PLA‐CF, and ABS‐CF are tested by maintaining a consistent layer thickness of 0.16 mm and 99.99% infill density while varying stress levels. PLA‐CF outperforms PLA, ABS, and ABS‐CF in fatigue life, with 0° print orientation exhibiting superior fatigue strength. Statistical analysis underscores the significance of print direction, material composition, and stress level. Additionally, the study aims to construct S‐N curves for 3D‐printed PLA/ABS composites with carbon fiber reinforcement, advancing our understanding of mechanical properties and print parameter optimization for enhanced fatigue performance in 3D‐printed composites.Highlights
Fatigue characteristics of 3D printed composites made from PLA and ABS, reinforced with carbon fiber investigated.
Four polymer composites were used: PLA, ABS, PLA‐CF (short carbon fiber), and ABS‐CF (short carbon fiber).
The research focused on the impact of 3D print orientation on fatigue properties, considering print angles of 0°, 45°/−45°, and 90°, alongside adjustable factor like motor speed and load.
With a consistent layer thickness of 0.16 mm and 99.99% infill density, the fatigue tests were conducted under stress‐controlled conditions at varying stress levels.
Results demonstrate that PLA‐CF specimens exhibit superior fatigue lifetimes compared to PLA, ABS, and ABS‐CF samples.
Monocyclopentadienyltitanium trichloride (CpTiCl3)/modified methylaluminoxane‐catalyzed polymerization of 2‐phenyl[3]dendralene: Homopolymerization and copolymerization of 2‐phenyl[3]dendralene with isoprene or styrene
Authors: Toda Tomoyuki , Kudo Shinya , Takenaka Katsuhiko 
Published: August 2024

AbstractThe control of the microstructures of polymer materials derived from diene‐based monomers is crucial, and various synthetic methods, including anionic, radical, and coordination polymerization reactions, have been extensively explored. Here, we demonstrated the coordination polymerization of 2‐phenyl[3]dendralenes (P3D) as a diene monomer. The polymerization process using monocyclopentadienyltitanium trichloride (CpTiCl3) as a catalyst and modified methylaluminoxane (MMAO) as a cocatalyst (CpTiCl3/MMAO) yielded polymers with an exclusive 4,6‐structure that is distinct from those produced by anionic polymerization. Furthermore, the copolymerization of P3D with isoprene and styrene proceeded randomly.
Stereoregular polyamides with optically‐pure aspartame‐type diketopiperazine derivatives
Authors: Takada Kenji , Yin Hongrong , Kaneko Tatsuo 
Published: August 2024

AbstractPolyamides (PAs) with aspartame‐derived diketopiperazine (DKP) form specific particles and exhibit high heat resistance. In this study, we investigated the stereostructures of aspartic acid and phenylalanine, which constitute aspartame DKP. Diketopiperazines with different stereostructures were synthesized from D‐ and L‐aspartic acid and D‐ and L‐phenylalanine, and LL‐, DD‐, and LD‐type aminodiketopiperazines (LL, DD, and LD‐ADKPs) were obtained. These ADKPs differed in their crystal forms depending on their stereoisomeric structures. Furthermore, PAs were formed from these ADKPs via polycondensation using triphenyl phosphite/pyridine, and their heat resistance was approximately 300 °C. The secondary structure of each PA was evaluated by circular dichroism, which suggested that LD‐type PAs had a mixed secondary structure of coils and helical structures, unlike the LL and DD types. Precipitated LL, DD, and LLcoDD PAs formed similar particles, whereas the particles of the large LD‐type PA had different particle shapes owing to their different conformations.
A comparison of antibody–antigen complex sequence‐to‐structure prediction methods and their systematic biases
Authors: McCoy Katherine Maia , Ackerman Margaret E. , Grigoryan Gevorg 
Published: August 2024

AbstractThe ability to accurately predict antibody–antigen complex structures from their sequences could greatly advance our understanding of the immune system and would aid in the development of novel antibody therapeutics. There have been considerable recent advancements in predicting protein–protein interactions (PPIs) fueled by progress in machine learning (ML). To understand the current state of the field, we compare six representative methods for predicting antibody–antigen complexes from sequence, including two deep learning approaches trained to predict PPIs in general (AlphaFold‐Multimer and RoseTTAFold), two composite methods that initially predict antibody and antigen structures separately and dock them (using antibody‐mode ClusPro), local refinement in Rosetta (SnugDock) of globally docked poses from ClusPro, and a pipeline combining homology modeling with rigid‐body docking informed by ML‐based epitope and paratope prediction (AbAdapt). We find that AlphaFold‐Multimer outperformed other methods, although the absolute performance leaves considerable room for improvement. AlphaFold‐Multimer models of lower quality display significant structural biases at the level of tertiary motifs (TERMs) toward having fewer structural matches in non‐antibody‐containing structures from the Protein Data Bank (PDB). Specifically, better models exhibit more common PDB‐like TERMs at the antibody–antigen interface than worse ones. Importantly, the clear relationship between performance and the commonness of interfacial TERMs suggests that the scarcity of interfacial geometry data in the structural database may currently limit the application of ML to the prediction of antibody–antigen interactions.
An analytical model for daily‐periodic slope winds. Part 2: Solutions
Authors: Marchio Mattia , Farina Sofia , Zardi Dino 
Published: August 2024

AbstractThis article presents an analytical model for the diurnal cycle of slope‐normal profiles of potential temperature and wind speed characterizing thermally driven slope winds, generated by a daily‐periodic surface energy budget. The model extends the solution proposed by Zardi and Serafin, originally formulated for a pure sinusoidal surface forcing temperature. To account for the asymmetric features characterizing the daytime and nighttime phases, a full Fourier series expansion is derived, the coefficients and phases of which are prescribed from the surface energy budget driven by the daily‐periodic radiation model described in Part 1 of the present work. The model is applicable for any slope angle () and orientation, at any latitude and elevation (up to 2500 m), and for all seasons. Despite some inherent limitations, the most remarkable being the absence of moist processes and latent heat fluxes, the model captures most key features of daily‐periodic slope wind systems, in particular the asymmetry between daytime and nighttime phases. Moreover, it allows exploration of the sensitivity of these flows to the various factors concurring in their development, and offers a basis for more realistic analytical solutions for slope winds.
Exploring Carbon Dots: Green Nanomaterials for Unconventional Lasing
Authors: Minervini Gianluca , Panniello Annamaria , Dibenedetto Carlo Nazareno , Madonia Antonino , Fanizza Elisabetta , Curri Maria Lucia , Striccoli Marinella 
Published: August 2024

AbstractIn recent years, the progress toward lighting miniaturization is focused on luminescent nanomaterials. Among them, fluorescent carbon dots (CDs) are receiving increasing attention thanks to their astonishing optical properties complemented by their intrinsic biocompatibility and low toxicity. The CDs can be easily dispersed in water, organic solvents or incorporated in polymeric matrices, preserving their emission properties. However, the relationship between their structural and optical properties is still not fully elucidated, motivating a consistent research effort for the comprehension of their features. Nevertheless, CDs demonstrate to be efficient gain materials for lasing, thanks to their high quantum yield (QY), emission tunability in the visible and near infrared (NIR) range, short lifetimes, and high absorption cross section, even if the synthetic reproducibility, the low reaction yield and the spectral width of the emission may limit their effective exploitation. This review summarizes the latest advancements in the investigation of the characteristic properties of CDs that make laser action possible, illustrating optical geometries for lasing and random lasing, both in solution and solid state, and the few currently demonstrated breakthroughs. While the journey toward their effective application is still long, the potential of CD‐based laser sources is promising in various technological fields and futuristic perspectives will be discussed.
An Ion‐Pumping Quasi‐Solid Electrolyte Enabled by Electrokinetic Effects for Stable Aqueous Zinc Metal Batteries
Authors: Gao Qixin , Zhao Jingteng , Xiao Huang , Gao Jian , Cheng Xin , Li Fang , Song Congying , Li Guoxing 
Published: August 2024

AbstractThe practical application of aqueous zinc (Zn) metal batteries (ZMBs) is hindered by the complicated hydrogen evolution, passivation reactions, and dendrite growth of Zn metal anodes. Here, an ion‐pumping quasi‐solid electrolyte (IPQSE) with high Zn2+ transport kinetics enabled by the electrokinetic phenomena to realize high‐performance quasi‐solid state Zn metal batteries (QSSZMBs) is reported. The IPQSE is prepared through the in situ ring‐opening polymerization of tetramethylolmethane‐tri‐β‐aziridinylpropionate in the aqueous electrolyte. The porous polymer framework with high zeta potential provides the IPQSE with an electrokinetic ion‐pumping feature enabled by the electrokinetic effects (electro‐osmosis and electrokinetic surface conduction), which significantly accelerates the Zn2+ transport, reduces the concentration polarization and overcomes the diffusion‐limited current. Moreover, the Zn2+ affinity of the polymer and hydrogen bonding interactions in the IPQSE changes the Zn2+ coordination environment and reduces the amount of free H2O, which lowers the H2O activity and inhibits H2O‐induced side reactions. Consequently, the highly reversible and stable Zn metal anodes are achieved. The assembled QSSZMBs based on the IPQSE display excellent cycling stability with high capacity retention and Coulombic efficiency. The high‐performance quasi‐solid state Zn metal pouch cells are demonstrated, showing great promise for the practical application of the IPQSE.