bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution
Authors: Humphries Adam , Cereser Biancastella , Gay Laura J. , Miller Daniel S. J. , Das Bibek , Gutteridge Alice , Elia George , Nye Emma , Jeffery Rosemary , Poulsom Richard , Novelli Marco R. , Rodriguez-Justo Manuel , McDonald Stuart A. C. , Wright Nicholas A. , Graham Trevor A. 
Published: June 2013

Significance
The organization of cells within human colorectal adenomas, and specifically whether the tumors are maintained by stem cells, is unclear. Furthermore, the patterns of clonal evolution leading to the development of a malignant tumor have not been determined. We performed lineage tracing in human adenomas using a combination of nuclear and mitochondrial DNA lesions and epigenetic markers. Our data identify a stem cell population within adenomas and suggest that new growth of intratumor clones occurs infrequently, not as a steady continual process as often is assumed. Our work offers a unique insight into human cancer development.
Abundance of Skeena River Chum Salmon during the Early Rise of Commercial Fishing
Authors: Price Michael H. H. , Gayeski Nick , Stanford Jack A. 
Published: June 2013

AbstractWe used reported commercial catch data and historical information to estimate the abundance of Skeena River Chum Salmon Oncorhynchus keta during the early rise (1916–1919) in the commercial fishery to provide historical perspective for recovery plans. We applied a Bayesian analysis to address the uncertainties associated with the estimation process. Based on the historical catch of 204,000 in 1919 and an estimated harvest rate of 0.32–0.58, the estimated return of Skeena Chum Salmon ranged from 355,000 to 619,000, with the most probable single estimate being 431,000. The estimated return of Chum Salmon based on the 1916–1919 geometric mean catch of 154,000 ranged from 268,000 to 471,000, with the most probable single estimate being 325,000. Our posterior modal historical estimates are 8–11 times larger than the estimates for the contemporary period 1982–2010 and 39–52 times larger than those for the most recent period of 2007–2010. Intense harvest pressure is the single most probable factor explaining the sustained decline in Chum Salmon abundance, but other interactive factors, notably natural variations in survival, the loss of spawning and rearing habitat, and poor data quality, also are important considerations. Nonetheless, the Skeena catchment is largely pristine today, and our robust estimates of historical abundance should be of value to contemporary management and conservation agencies for the rebuilding of such severely diminished populations.
Alligator Gar Movement and Macrohabitat Use in the Lower Trinity River, Texas
Authors: Buckmeier David L. , Smith Nathan G. , Daugherty Daniel J. 
Published: June 2013

AbstractUsing acoustic telemetry, we characterized movements and macrohabitat use of 46 Alligator Gars Atractosteus spatula in the lower 180 km of the Trinity River, Texas. Although several Alligator Gars used over 100 km of the river, 83% of the tagged fish had linear home ranges less than 60 km during the 22 months of study. As a result, home ranges of fish that were tagged in different parts of the study area rarely overlapped. Home range size varied by season, with the smallest home ranges occurring in winter. Greatest movements occurred during the spawn (May–June) and postspawn (July–October) seasons, and movements were correlated with increasing water temperatures based on detections of tagged fish at fixed receiver stations. Tagged Alligator Gars were most often associated with main‐channel habitats when river stage was at base level and during small flood pulses (<3‐m rise). When in the main channel, tagged Alligator Gars selected water that was deeper than the average within their home ranges. In contrast, during large flood pulses (≥3‐m rise), tagged fish were found in tributaries and inundated floodplains, regardless of season. Use of tailwater and estuarine macrohabitats was seasonal and limited to fish that had been tagged near those areas. Limited home ranges and observed spatial segregation of fish tagged near the upper and lower boundaries of the 180‐km study area suggest that the fish have access to critical habitats needed for reproduction, feeding, and migration within relatively small spatial scales. As such, Alligator Gars in the lower Trinity River do not appear to represent a single panmictic population, indicating that localized rather than regional management efforts would be appropriate.
Assessing parental impact on the sports participation of children: A socio‐economic analysis of the UK
Authors: Downward Paul , Hallmann Kirstin , Pawlowski Tim 
Published: June 2013

AbstractThis study examines the effects of parental attitudes on children's physical activity. A measure of parental attitude (their sport participation when being young) that is independent of the child's behaviour is needed. Using data from the sixth wave of the Taking Part Survey (n =14,002 adults and n =1116 children), a matching estimator analysis is conducted. The results reveal that there are substantial intergenerational transfers of behaviours, in particular for male adults and male children. Furthermore, while an effect is observed for female adults and male children, female children's sport participation is only marginally influenced by female adult's physical activity when growing up. The results imply that promoting sport to the younger generation seems to be a fruitful strategy in creating a sporting habit and promoting sport participation when being older. However, there are challenges to be overcome in promoting female participation.
Managing uncertainty in thermal water quality trading programs
Authors: Bier Asmeret , Budd William , Fiedler Fritz 
Published: June 2013

Abstract
Thermal water quality trading is an emerging policy tool that allows thermal polluters to comply with effluent restrictions by paying nearby landowners to plant shade trees. We created a system dynamics model of a hypothetical thermal trading program and conducted scenario analysis to study how weather, climate, and trading behavior might influence program effectiveness. It is likely that neither thermal trading nor conventional regulation can reduce water temperatures to desired levels, but the model indicates that trading ratios, used to account for uncertainty, lead programs to decrease water temperatures below those produced through conventional regulation.
Metingear: a development environment for annotating genome-scale metabolic models
Authors: May John W. , James A. Gordon , Steinbeck Christoph 
Published: June 2013

Abstract
Summary: Genome-scale metabolic models often lack annotations that would allow them to be used for further analysis. Previous efforts have focused on associating metabolites in the model with a cross reference, but this can be problematic if the reference is not freely available, multiple resources are used or the metabolite is added from a literature review. Associating each metabolite with chemical structure provides unambiguous identification of the components and a more detailed view of the metabolism. We have developed an open-source desktop application that simplifies the process of adding database cross references and chemical structures to genome-scale metabolic models. Annotated models can be exported to the Systems Biology Markup Language open interchange format.
Availability: Source code, binaries, documentation and tutorials are freely available at http://johnmay.github.com/metingear. The application is implemented in Java with bundles available for MS Windows and Macintosh OS X.
Contact: johnmay@ebi.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
Invasion of Old World Phragmites australis in the New World: precipitation and temperature patterns combined with human influences redesign the invasive niche
Authors: Guo Wen‐Yong , Lambertini Carla , Li Xiu‐Zhen , Meyerson Laura A. , Brix Hans 
Published: June 2013

AbstractAfter its introduction into North America, Euro‐Asian Phragmites australis became an aggressive invasive wetland grass along the Atlantic coast of North America. Its distribution range has since expanded to the middle, south and southwest of North America, where invasive P. australis has replaced millions of hectares of native plants in inland and tidal wetlands. Another P. australis invasion from the Mediterranean region is simultaneously occurring in the Gulf region of the United States and some countries in South America. Here, we analysed the occurrence records of the two Old World invasive lineages of P. australis (Haplotype M and Med) in both their native and introduced ranges using environmental niche models (ENMs) to assess (i) whether a niche shift accompanied the invasions in the New World; (ii) the role of biologically relevant climatic variables and human influence in the process of invasion; and (iii) the current potential distribution of these two lineages. We detected local niche shifts along the East Coast of North America and the Gulf Coast of the United States for Haplotype M and around the Mississippi Delta and Florida of the United States for Med. The new niche of the introduced Haplotype M accounts for temperature fluctuations and increased precipitation. The introduced Med lineage has enlarged its original subtropical niche to the tropics‐subtropics, invading regions with a high annual mean temperature (> ca. 10 °C) and high precipitation in the driest period. Human influence is an important factor for both niches. We suggest that an increase in precipitation in the 20th century, global warming and human‐made habitats have shaped the invasive niches of the two lineages in the New World. However, as the invasions are ongoing and human and natural disturbances occur concomitantly, the future distribution ranges of the two lineages may diverge from the potential distribution ranges detected in this study.
Methicillin‐resistant Staphylococcus aureus carriage in hospitalized chronic hemodialysis patients and its predisposing factors
Authors: Yeoh Lee Ying , Tan Feng Ling Grace , Willis George Christopher , Ooi Say Tat 
Published: June 2013

AbstractThere has been a paucity of literature on methicillin‐resistant Staphylococcus aureus (MRSA) colonization in chronic hemodialysis patients who required admission. The purpose of this study is to determine the MRSA carriage rate in hospitalized chronic hemodialysis patients, to identify the risk factors, and assess the consequences of MRSA colonization. This was a retrospective study of hospitalized chronic hemodialysis patients at Khoo Teck Puat Hospital from July 1, 2010 to June 30, 2011. MRSA screening was done on the day of admission using culture method with MRSA select (Bio‐Rad)™. The patients were divided into two groups: MRSA carriers and noncarriers. Demographic data, medical, and laboratory information was obtained via electronic medical record system. Outcome measures were infection rates during current hospitalization episode, frequency of hospitalization, and cumulative hospitalization days per year. Prevalence rate of MRSA colonization in hospitalized chronic hemodialysis patients was 15.1%, compared to all admitted patients (5.8%). Diabetes mellitus, Malay ethnicity, shorter hemodialysis duration and use of tunneled hemodialysis catheters were associated with MRSA colonization (P < 0.05). Relative risk of infection during the episode of admission among MRSA carriers was 3.2‐fold compared to noncarriers. MRSA colonization rates tend to be higher in patients on hemodialysis for less than 3 years and it correlates with longer hospitalization after adjustment for other variables (P < 0.05). Patients on chronic hemodialysis requiring admission have higher rates of MRSA colonization. The risk factors of MRSA carriers and the correlation of MRSA rates to longer hospitalization suggest its nosocomial origin in this group of patients.
“Right Here is the Gateway”: Mobility, Sex Work Entry and HIV Risk along the Mexico–US Border
Authors: Goldenberg S.M. , Silverman J.G. , Engstrom D. , Bojorquez‐Chapela I. , Strathdee S.A. 
Published: June 2013

AbstractWomen comprise an increasing proportion of migrants. Many migrate voluntarily for sex work or practise survival sex; others are trafficked for sexual exploitation. To investigate how the context of mobility shapes sex work entry and HIV risk, during 2010 to 2011 we conducted in‐depth interviews with formerly trafficked women currently engaged in sex work (n = 31) in Tijuana and their service providers (n = 7) in Tijuana and San Diego. Women's experiences of coerced and deceptive migration, deportation as forced migration, voluntary mobility, and migration to a risk environment illustrate that circumstances resulting from migration shape vulnerability to sex trafficking, voluntary sex work entry, and HIV risk. Findings suggest an urgent need for public health and immigration policies providing integrated support for deported and/or recently arrived female migrants. Policies to prevent sex trafficking and assist trafficked females must consider the varying levels of personal agency involved in migration and sex work entry.
Policy Implications

There is a need for coordination between public health and immigration policies to ensure that these are not at odds with one another

Findings suggest the need for public health and immigration policies that provide integrated support for female migrants, especially trafficked women and girls

Policy changes are urgently needed to protect deportees' health and promote their social integration

Policies to prevent sex trafficking and assist trafficked females must consider the range of agencies involved in migration and sex work entry
ARE C‐REACTIVE PROTEIN AND FERRITIN LEVELS BEING OVERLOOKED IN INDIGENOUS AUSTRALIANS WITH CHRONIC KIDNEY DISEASE?
Authors: Claes Jamin , Ellis Joy‐Anne L. , Rettie Fiona , Butcher Belinda , Bradley Jennifer 
Published: June 2013

SUMMARYBackgroundIndigenous Australians have significantly higher rates of end‐stage renal disease and worse health outcomes than non‐indigenous Australians.ObjectivesWe investigated whether the effect of inflammation on C‐reactive protein (CRP) and ferritin levels is being overlooked in indigenous patients with chronic kidney disease.DesignData for 23,000 patients were extracted from the Renal Anaemia Management database for the period November 1999 to October 2010.MeasurementHaemoglobin, ferritin, transferrin saturation and CRP levels for indigenous and non‐indigenous Australians were compared with target levels given in the Caring for Australians with Renal Impairment (CARI) guidelines.ResultsCompared with non‐indigenous patients, indigenous Australians had higher median CRP and mean ferritin levels, lower mean haemoglobin level and were less likely to meet CARI targets.ConclusionThe effect of inflammation on laboratory parameters should be considered particularly when treating indigenous Australians.
Emotional rescue: the role of emotional intelligence and emotional labour on well‐being and job‐stress among community nurses
Authors: Karimi Leila , Leggat Sandra G. , Donohue Lisa , Farrell Gerald , Couper Greta E. 
Published: June 2013

AbstractAimsTo investigate the extent to which emotional labour and emotional intelligence are associated with well‐being and job‐stress among a group of Australian community nurses. The moderating role of emotional intelligence was evaluated as a key factor in the rescue of healthcare workers from job‐stress, thus increasing job retention.BackgroundAlthough emotional labour has been broadly investigated in the literature, the contribution of emotional labour and emotional intelligence to the well‐being and experience of job‐stress in a community nursing setting requires further exploration.DesignThis study used a cross‐sectional quantitative research design with data collected from Australian community nurses.MethodsAustralian community nurses (n = 312) reported on their perceived emotional labour, emotional intelligence and their levels of well‐being and job‐stress using a paper and pencil survey in 2010.Results/FindingsResults from structural equation modelling support the hypothesis that both emotional labour and emotional intelligence have significant effects on nurses' well‐being and perceived job‐stress. Emotional intelligence plays a moderating role in the experience of job‐stress.ConclusionThese findings provide additional evidence for the important effects that emotional labour and emotional intelligence can have on well‐being and job‐stress among community nurses. The potential benefits of emotional intelligence in the nurses' emotional work have been explored.
Absence of circulating mast cell precursors in paediatric mastocytosis: could it reflect a different pathophysiology between adults and children with mastocytosis?
Authors: Georgin‐Lavialle S. , Le Saché‐de Peufeilhoux L. , Martin L. , Soucie E. , Bruneau J. , Barete S. , Dubreuil P. , Bodemer C. , Hermine O. , Lhermitte L. 
Published: June 2013

AbstractBackgroundMastocytosis is a heterogeneous disease whose different subtypes also vary in aggressivity. Children typically present with cutaneous mastocytosis. We identified, in our previous work, a peripheral CD34‐c‐Kit+mast cell precursor by flow cytometry in systemic forms but not in cutaneous forms of adult mastocytosis.ObjectivesWe wanted to know if such a mast cell precursor exists among children with mastocytosis.MethodsWe analysed 10 children with mastocytosis for c‐Kit+CD34‐ mast cell precursors by flow cytometry.ResultsIn contrast to adults with mastocytosis, we did not detect any circulating mast cell precursors by flow cytometry in the peripheral blood of children with mastocytosis.ConclusionThe clinical symptoms observed among children with cutaneous mastocytosis could be induced by cutaneous mast cell mediators and not by circulating mast cells. These results may help to better understand the differences between adult and childhood mastocytosis.
Performance of the experimental resins and dental nanocomposites at varying deformation rates
Authors: Kumar Naresh , Shortall Adrian 
Published: June 2013

AbstractAimThe aim of the present study was to evaluate the bi‐axial flexural strength of experimental unfilled resins and resin‐based composites at varying deformation rates following 1‐week dry, 1‐week wet, and 13‐week wet storage regimes.MethodsA total of 270 disc‐shaped specimens (12 mm diameter, 1 mm thickness) of either unfilled resins or experimental resin‐based composites comprising of three groups (n = 90) were fabricated. Three groups of each unfilled resin and resin‐based composites (n = 90) were stored for 1 week under dry conditions, and at 1 and 13 weeks under wet conditions (37 ± 1°C) before testing. The bi‐axial flexural strength of each unfilled resin and resin‐based composites group was determined at a 0.1, 1, and 10 mm/min deformation rate (n = 30).ResultsThe unfilled resins revealed a deformation rate dependence following all storage regimes; however, the addition of fillers in the unfilled resins modified such reliance following the 1‐week dry and 13‐week wet storage regimes. In contrast, a lower bi‐axial flexural strength of the 1‐week wet resin‐based composites specimens at a 0.1 mm/min deformation rate was identified.ConclusionA lower bi‐axial flexural strength of the 1‐week wet resin‐based composites specimens at a low deformation rate suggests that premature failure of resin‐based composites restorations might occur in patients with parafunctional habits, such as bruxism.
Effects of surface roughness and dimorphism on the adhesion of Candida albicans to the surface of resins: scanning electron microscope analyses of mode and number of adhesions
Authors: Mayahara Mitsuori , Kataoka Ryuta , Arimoto Takafumi , Tamaki Yukimichi , Yamaguchi Nobuaki , Watanabe Yuki , Yamasaki Yoshizumi , Miyazaki Takashi 
Published: June 2013

AbstractAimCandida albicans is a common oral fungus but can cause serious conditions such as Candida stomatitis. We investigated C. albicans adhesion to the surface of denture‐base resins at two growth phases.MethodsFungal suspensions of logarithmic (9 h) and stationary phase (24 h) C. albicans (JCM2085) were used. Scanning electron microscopy (SEM) confirmed that yeast and mycelial forms were predominant in 9‐h and 24‐h cultures, respectively. Resin strips were polished to three surface roughness levels (Ra 3.2 μm, Ra 0.48 μm and Ra 0.06 μm) and were then immersed in C. albicans suspensions for both phases. The SEM images were taken at five sites on each strip.ResultsAdhesion of mycelial‐form C. albicans on rough surfaces (Ra = 3.2) was 2.2 times higher than on smooth surfaces (Ra = 0.06; 7030 vs 3580 adhesions/mm2, P < 0.01). The hyphae of these mycelial forms fully penetrated the surface cracks. Fewer adhesions occurred for yeast‐form C. albicans, regardless of surface type (440–620 adhesions/mm2, P = n.s.).ConclusionAdhesion of yeast‐form C. albicans was indifferent to surface roughness. In contrast, mycelial adhesion increased with surface roughness of the resin because mycelia infiltrated the minute protuberances on rough surfaces.
Linkages of Farmers' Operations with Rhizoctonia Root Rot Spread in Bean Crops on a Regional Basis
Authors: Naseri Bita 
Published: June 2013

AbstractThe associations of Rhizoctonia root rot (RRR) with a number of agronomic and yield variables were characterized at different growth stages in 122 commercial bean fields in Zanjan, Iran. A lower RRR incidence was detected in red beans compared with white beans. RRR incidence was greater in drought‐exposed fields compared with drought‐free fields. RRR incidence was higher following frequent irrigations at 2‐ to 3‐day intervals than at 4‐ to 9‐day intervals. The highest RRR incidence was associated with the densest category of plant populations and with the deepest plantings at 10–22 cm. Beans grown following alfalfa, bean and maize had a lower disease than rotations with potato. RRR incidence was greater in fields that received 50–500 kg/ha of urea compared with nonfertilized fields. RRR‐affected fields were recognized with a closer irrigation, earlier and deeper planting, denser weed population and lower yields than RRR‐free fields. According to loadings for second principal component, planting density and depth, urea usage and weed density corresponded with RRR incidence. Findings extend our understanding of RRR epidemics in diverse bean cropping systems.
Ensuring regulatory compliance in banking and finance through effective controls: The principle of duality in the segregation of duties
Authors: Engdahl Oskar 
Published: June 2013

AbstractToday the segregation of duties is commonly used to ensure regulatory compliance in various industries. This article considers the organizational requirements for the effective implementation of this principle, through an examination of a duality‐based segregation‐of‐duties type control system and its fundamental characteristics. Cases from theSwedish banking and finance sector are discussed to show how breakdowns in duality‐based systems have compromised compliance and even encouraged crime, and how crimes could be carried out in practice. Particular attention is paid to the critical role that gullibility, loyalty, and dependency relations among employees played in these cases, in leading control persons to neglect their responsibility to review and approve their colleagues’ work, while bringing no consequences for their ability to carry on performing their work tasks. The argument is made that an effective duality‐based segregation‐of‐duties type control system presupposes social relations characterized by relative autonomy and third‐party dependence, along with work task interdependence.