bluuebunny/crossref_metadata_2025_split huggingface dataset:
CEOs family on the boardroom and environmental, social, and governance disclosure: Exploring from economic crisis during COVID‐19
Authors: Ardianto Ardianto , Cahyono Suham , Sulaiman Noor Adwa 
Published: August 2024

AbstractThis study examines the relationship between family‐run businesses and the quality of environmental, social, and governance (ESG) disclosure, with a specific focus on the influence of the COVID‐19 pandemic. Drawing on a sample of 559 firm‐year observations from publicly listed companies in ASEAN countries spanning from 2019 to 2022, this study measure ESG disclosure quality using the global reporting initiative guidelines for sustainability reports. Family‐run businesses are identified as those with family members serving on the board of directors. This study finding reveals that family‐run businesses exhibit higher ESG disclosure quality compared to companies without family representation on their boards. Furthermore, results show a significant positive impact of the COVID‐19 pandemic on the relationship between family‐run businesses and their ESG disclosure practices. The implications of this study are significant for various stakeholders, including owners, management, and regulators. This research contributes to the existing literature by offering empirical evidence on the relationship between family‐run businesses and ESG disclosure within the context of ASEAN countries, particularly amidst the COVID‐19 pandemic. By shedding light on the positive association between family involvement and ESG disclosure quality, this study provides valuable insights for practitioners and policymakers seeking to promote sustainable business practices in emerging markets.
A case report of metformin‐associated lactic acidosis
Authors: Taha Mohammed , Azhary Ayman , Hajhamed Nooh Mohamed , Sir Alkhatim Waleed Azhary , Bakheit Abdullah M. , Ahmed Abdallah Elssir 
Published: August 2024

Key Clinical MessageMetformin‐associated lactic acidosis is a rare but serious complication in patients with type 2 diabetes, especially those with multiple health conditions. Prompt recognition and treatment, including potential renal replacement therapy, are crucial for managing severe acidosis and improving patient outcomes.AbstractMetformin (MTF) is commonly prescribed as a first‐line treatment for diabetes, effectively preventing microvascular and macrovascular complications. However, metformin‐associated lactic acidosis is a rare yet severe complication, associated with a mortality rate of up to 50%. We encountered a case involving a 73‐year‐old woman with type 2 diabetes, mental illness, and hypothyroidism, who developed life‐threatening lactic acidosis while on metformin therapy. Upon presenting to the emergency department with complaints of weakness, nausea, and decreased urination for 5 days, she also reported abdominal pain and shortness of breath. Hypotension was noted with a blood pressure of 80/50 mmHg. Initial laboratory results revealed severe acidosis, prompting discontinuation of MTF. Despite resuscitation efforts and vasopressor therapy, severe acidemia persisted, leading to the initiation of renal replacement therapy. Following treatment with continuous renal replacement therapy, her acidemia resolved, and she was discharged from the hospital on the sixth day without complications, with normal kidney function.
Visible Light‐Sensitized CO2 Methanation along a Relaxed Heat Available Route
Authors: Du Yangyang , Ma Dongge , Li Jiazhen , Huang Qiang , He Qin , Ji Jianfei , Ji Hongwei , Ma Wanhong , Zhao Jincai 
Published: August 2024

AbstractIn photocatalysis, the resulted heat by the relaxation of most of incident light no longer acts as the industrially favorite driving force back to the target photo‐reaction due to more or less the negative relation between photocatalytic efficiency and temperature. Here, we reported a visible light‐sensitized protocol that completely reversed the negatively temperature‐dependent efficiency in photo‐driven CO2 methanation with saturated water vapor. Uniform Pt/N‐TiO2/PDI self‐assembly material decisively injects the excited electron of PDI sensitizer into N‐TiO2 forming Ti−H hydride which is crucially temperature‐dependent nucleophilic species to dominate CO2 methanation, rather than conventionally separated and trapped electrons on the conductor band. Meanwhile, the ternary composite lifts itself temperature from room temperature to 305.2 °C within 400 s only by the failure excitation upon simulated sunlight of 2.5 W/cm2, and smoothly achieves CO2 methanation with a record number of 4.98 mmol g−1 h−1 rate, compared to less than 0.02 mol g−1 h−1 at classic Pt/N‐TiO2/UV photocatalysis without PDI sensitization. This approach can reuse ~53.9 % of the relaxed heat energy from the incident light thereby allow high‐intensity incident light as strong as possible within a flowing photo‐reactor, opening the most likely gateways to industrialization.
Facile Preparation and Study of Self‐Healing Water‐Absorbing Expanding Elastomers
Authors: Lu Wentong , Liu Fengyi , Zhu Yiyao , Wang Jincheng , Tian Hao , Zhou Peilong , Li Long 
Published: August 2024

AbstractThe absorbent expansion elastomer plays a crucial role in engineering sealing and holds a promising future in this field as infrastructure continues to develop. Traditional materials have their limitations, especially when used in large construction projects where the integrity and reliability of the material are of utmost importance. In this work, a self‐healing water‐absorbing expansion elastomer was developed for continuous production at a large scale to monitor the sealing conditions of massive infrastructure projects. At room temperature, the material exhibited a repairing efficiency of 57.77 % within 2 h, which increased to 84.02 % after 12 h. This extended reaction time allowed for effective repairs when defects were detected. The material's strength can attain 3 MPa, placing it at the upper echelon among common self‐healing materials, thereby granting it a certain level of durability in its application environment. The material's volume expansion rate reached 200–400 % to achieve effective sealing, and the functional filling of the filler endowed the material itself with a favorable external force induction effect and prevented heat accumulation. The conductive detection performance of the absorbent expansion elastomer was improved by utilizing triple self‐healing strategies, including dipole‐dipole interaction, ion cross‐linked network, and externally‐aided restoration materials. These strategies were combined with a double packing strategy to enhance the material's properties. This innovative elastomer can be applied in various fields such as tunnel construction, infrastructure development, aerospace sealing, and railway transportation, showcasing significant potential for diverse engineering applications.
Selective Recruitment of Antibodies to Cancer Cells and Immune Cell‐mediated Killing via In Situ Click Chemistry
Authors: Ankrom Emily , Dalesandro Brianna , Pires Marcos M. , Thévenin Damien 
Published: August 2024

AbstractMany current cancer immunotherapies function by redirecting immune system components to recognize cancer biomarkers and initiate a cytotoxic attack. The lack of a universal tumor biomarker limits the therapeutic potential of these approaches. However, one feature characteristic of nearly all solid tumors is extracellular acidity. This inherent acidity provides the basis for targeted drug delivery via the pH‐low insertion peptide (pHLIP), which selectively accumulates in tumors in vivo due to a pH‐dependent membrane insertion propensity. Previously, we established that we could selectively decorate cancer cells with antigen‐pHLIP conjugates to facilitate antibody recruitment and subsequent killing by engineered effector cells via antibody‐dependent cellular cytotoxicity (ADCC). Here, we present a novel strategy for opsonizing antibodies on target cell surfaces using click chemistry. We utilize pHLIP to facilitate selective tetrazine ‐ trans‐cyclooctene ligation of human IgGs to the cancer cell surface and induce ADCC. We demonstrate that our approach activates the primary ADCC signaling pathway via CD16a (FcγRIIIa) receptors on effector cells and induces the killing of cancer cell targets by engineered NK cells.
Li1.3Al0.3Ti1.7P3O12 activated PVDF solid electrolyte for advanced lithium–oxygen batteries
Authors: Ou Caizheng , Zhang Hao , Ma Dan , Mu Hailiang , Zhuge Xiangqun , Ren Yurong , Bayati Maryam , Xu Ben Bin , Liu Xiaoteng , Zou Xiaoqin , Luo Kun 
Published: August 2024

AbstractLithium‐ion composite solid electrolyte membranes embedded with Li1.3Al0.3Ti1.7P3O12 and poly(vinylidene fluoride) are prepared using a facile casting method. Furthermore, we added LiI as an active agent for decomposing the anode product. The synergy resulted in a high conductivity of 7.4 mS·cm−1 and lithium‐ion mobility of 0.59 and a reduction of the overpotential to 0.86 V for lithium–oxygen batteries (LOBs). The membrane has enhanced Young's modulus of 6.6 GPa that effectively blocked the lithium dendrite growth during the battery operation and puncturing to the membrane led to a significant LOB cycle life of 542 cycles. Meanwhile, Li|Li symmetrical battery overpotential maintained at 42 mV after 470 h of operation.image
More widespread functionality of posterior language area in patients with brain tumors
Authors: Nakajima Riho , Osada Takahiro , Kinoshita Masashi , Ogawa Akitoshi , Okita Hirokazu , Konishi Seiki , Nakada Mitsutoshi 
Published: August 2024

AbstractDamage to the posterior language area (PLA), or Wernicke's area causes cortical reorganization in the corresponding regions of the contralateral hemisphere. However, the details of reorganization within the ipsilateral hemisphere are not fully understood. In this context, direct electrical stimulation during awake surgery can provide valuable opportunities to investigate neuromodulation of the human brain in vivo, which is difficult through the non‐invasive approaches. Thus, in this study, we aimed to investigate the characteristics of the cortical reorganization of the PLA within the ipsilateral hemisphere. Sixty‐two patients with left hemispheric gliomas were divided into groups depending on whether the lesion extended to the PLA. All patients underwent direct cortical stimulation with a picture‐naming task. We further performed functional connectivity analyses using resting‐state functional magnetic resonance imaging (MRI) in a subset of patients and calculated betweenness centrality, an index of the network importance of brain areas. During direct cortical stimulation, the regions showing positive (impaired) responses in the non‐PLA group were localized mainly in the posterior superior temporal gyrus (pSTG), whereas those in the PLA group were widely distributed from the pSTG to the posterior supramarginal gyrus (pSMG). Notably, the percentage of positive responses in the pSMG was significantly higher in the PLA group (47%) than in the non‐PLA group (8%). In network analyses of functional connectivity, the pSMG was identified as a hub region with high betweenness centrality in both the groups. These findings suggest that the language area can spread beyond the PLA to the pSMG, a hub region, in patients with lesion progression to the pSTG. The change in the pattern of the language area may be a compensatory mechanism to maintain efficient brain networks.
Validation of the Bangla version of the Communication Skills Attitude Scale with the medical students of Bangladesh
Authors: Islam Mohammad Aminul , Benzir Maskura , Siddique Md. Kaoser Bin , Awal Md. Abdul , Chowdhury Mohiuddin Ahsanul Kabir , Joarder Taufique 
Published: August 2024

AbstractBackgroundEffective communication skill of physicians is an important component of high‐quality healthcare delivery and safe patient care. Communication is embedded in the social and cultural contexts where it takes place. An understanding of medical students' attitudes and learning communication skills would help to design and deliver culturally appropriate medical education. The Communication Skills Attitude Scale (CSAS) is a widely used and validated tool to measure the attitude of medical students toward learning communication skills in different populations, settings, and countries. However, there is no culturally adapted and validated scale in Bangla in the Bangladesh context. This study aims to culturally adapt the CSAS into Bangla, and validate it in a cohort of medical students in Bangladesh.MethodsThis study used a cross‐sectional survey design to collect data from purposively selected 566 undergraduate medical students from the Rajshahi division. The survey was conducted from January to December 2023. Descriptive statistics like frequency distribution and measures of central tendency were used to measure perception regarding communication skills. The sample adequacy was measured through the Kaiser–Meyer–Olkin test. The internal consistency of the items was identified using Cronbach's alpha (α) coefficients.ResultThe results of the study show that the Bangla version of the scale is feasible, valid, and internally consistent in the context of a developing country, Bangladesh. The overall internal consistency of the Bangla version is good since the value of Cronbach's alpha (α) is 0.882. For PAS, the internal consistency is 0.933. While, for NAS, the value is 0.719. The item‐wise average scores in the PAS indicate that female medical students are more willing to learn communication skills compared with male students (α = 0.933). While, the scores in the NAS indicate that the male students tend to have more negative attitude toward learning communication skills compared with female students (α = 0.719).ConclusionThe CSAS‐Bangla is a valid and reliable tool for assessing communication skill attitudes among Bangla speaking medical students. This scale can be used in future studies to measure the attitude of students, designing and evaluating communication skills training programs in medical colleges.
Teaching learners to identify and reduce the spread of medical misinformation
Authors: Johnson Steven Theodore , Goldwire Micheline Andel , Abdalla Maha , Advani Ashish , Alhammad Abdullah M. , Anderson Keri C. , Bernknopf Allison , Blommel Matthew L. , Brunner Rachel , Frazier JorDonna , Gor Prit , Gosser Rena , Ipema Heather , Kier Karen L. , Kostrzewa Audrey , Majerczyk Daniel , Manian Radha , Maxwell Erin , May Dianne , May J. Russell , Munir Faria , Okafar Ife , Phillips Jennifer , Poore Alia A. , Saad Maha , Sibbesen Julie B. , Sommer Christine D. 
Published: August 2024

AbstractPharmacists play a key role in helping to identify and combat the spread of medical misinformation. To do this effectively, pharmacists need to be equipped with skills and tools to respond to medical misinformation as it relates to patient care. The lack of peer‐reviewed research on how to approach medical misinformation illustrates the need for specific strategies on how to identify, combat, and report medical misinformation. This article describes practical tactics pharmacists can use to teach learners the knowledge and skills necessary to reduce the spread of medical misinformation from various sources, including social media and artificial intelligence.
Effects of Food, Gastric Acid Reduction, and Strong CYP3A Induction on the Pharmacokinetics of Tasurgratinib, a Novel Selective Fibroblast Growth Factor Receptor Inhibitor
Authors: Nomoto Maiko , Hasunuma Tomoko , Cai Cuiyuan , Suzuki Ippei , Mikubo Ayano , Funasaka Setsuo , Otake Yohei , Nakai Kenya , Yasuda Sanae 
Published: August 2024

AbstractWe conducted this three‐part study in healthy subjects to investigate the pharmacokinetics of tasurgratinib (orally available selective inhibitor of fibroblast growth factor receptor 1‐3) and M2 (its major metabolite) under different conditions. In Part A, subjects received tasurgratinib 35 mg either fed with a high‐fat meal or fasted. In Parts B and C, subjects received tasurgratinib 35 mg alone or with either rabeprazole (acid‐reducing agent) 20 mg (Part B) or rifampin (strong CYP3A inducer) 600 mg (Part C). Primary endpoints were maximum concentration (Cmax), and areas under the plasma concentration‐time curve to time of last quantifiable concentration (AUC(0‐t)) and extrapolated to infinite time (AUC(0‐inf)). Forty‐two subjects were enrolled, 14 each into Parts A, B, and C. In Part A, administration of tasurgratinib with a high‐fat meal resulted in 33% reduction in Cmax and ∼23% reduction in AUC(0‐t) and AUC(0‐inf) of tasurgratinib, and 47% reduction in Cmax with ∼30% reduction in AUC(0‐t) and AUC(0‐inf) of M2. In Part B, co‐administration of rabeprazole at steady state resulted in no/weak interaction with tasurgratinib (∼8% increase in AUC(0‐t) and AUC(0‐inf) without an effect on Cmax) and M2 (∼18% increase in AUC(0‐t) and AUC(0‐inf) without an effect on Cmax). In Part C, co‐administration of rifampin at steady state resulted in a weak interaction with tasurgratinib (∼16% reduction in AUC(0‐t) and AUC(0‐inf)) and M2 (∼12% reduction in AUC(0‐t) and AUC(0‐inf)). Administration of tasurgratinib with a high‐fat meal appeared to reduce systemic exposure of tasurgratinib, however co‐administration with an acid‐reducing agent or a CYP3A inducer had a minimal impact on pharmacokinetics.
Synthesized alternative reinforcement and resurgence
Authors: Smith Sean W. , Arroyo Antúnez Beatriz E. , DeBartelo Jacqueline , Sullivan William E. , Roane Henry S. , Craig Andrew R. 
Published: August 2024

AbstractIn treatments based on differential reinforcement of alternative behavior, applied researchers and clinicians often provide multiple, qualitatively different reinforcers (i.e., synthesized reinforcement) rather than a single reinforcer (i.e., isolated reinforcement) contingent on alternative behavior. Some research shows that providing synthesized reinforcement for alternative responses within such treatments produces more rapid and complete suppression of target behavior; however, there is limited research evaluating the durability of these effects during treatment disruptions. Conceptual explanations of resurgence (e.g., resurgence as choice, context theory) suggest that treatments that include synthesized alternative reinforcement may lead to more resurgence of target behavior when alternative reinforcement is disrupted relative to treatments using isolated reinforcement. We evaluated this hypothesis within a three‐phase resurgence evaluation. We exposed rats to isolated or synthesized reinforcement for alternative responding in the second phase, and we exposed rats to extinction in the third phase. Synthesized alternative reinforcement produced more rapid and complete suppression of target behavior than did isolated reinforcement in the second phase; however, exposure to extinction following synthesized reinforcement produced more resurgence. We discuss these results in terms of their implications for applied research and their support for current conceptual explanations for resurgence.
Soil fertilization with microalgae biomass from municipal wastewater treatment causes no additional leaching of dissolved macronutrients and trace elements in a column experiment
Authors: Weigand Harald , Velten Hermann , Düring Rolf‐Alexander , Chifflard Peter , Rohnke Marcus , Weintraut Timo , Heusch Steffen , Theilen Ulf 
Published: August 2024

AbstractMicroalgae are a promising bio‐fertilizer that can be cultivated in municipal wastewater, where the organisms perform water purification by incorporation of nutrients and contaminants. Before bio‐fertilization with wastewater‐grown microalgae can be put into practice, its impact on the leaching of macronutrients and trace elements needs to be evaluated. Here, we studied the leaching behavior of a microalgae‐fertilized soil against a control in column percolation setup. Microalgae were grown in real municipal wastewater supplemented with bromide for the analysis of within‐cell Br− accumulation by time‐of‐flight secondary ion mass spectrometry. Dry biomass (45.0 g N kg−1 and 28.9 g P kg−1) was added to the topmost layer of the fertilized column at a level of 3 g biomass kg−1 on a whole soil basis. Column irrigation was equivalent to 3 years of precipitation in central Germany. The leaching of macronutrients and trace elements from the fertilized and control columns was largely identical. Except for P, depth profiles confirmed very low vertical translocation within the soil. This is held for total element contents as well as for operationally defined pools, suggesting that microalgae cultivated in municipal wastewater provide a slow‐release fertilizer largely resistant to leaching. Mass spectrometric imaging gave clear evidence for bromide uptake by the microalgae, and pure cultures of the genus Scenedesmus showed that it was preferentially located in the cell membrane. Therefore, bromide could potentially be employed as a mineralization tracer in future studies on the use of microalgae as a bio‐fertilizer.
Mesenchymal stromal/stem cell tissue source and in vitro expansion impact extracellular vesicle protein and miRNA compositions as well as angiogenic and immunomodulatory capacities
Authors: Liu Yuan , Sun Li , Li Yan , Holmes Christina 
Published: August 2024

AbstractRecently, therapies utilizing extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have begun to show promise in clinical trials. However, EV therapeutic potential varies with MSC tissue source and in vitro expansion through passaging. To find the optimal MSC source for clinically translatable EV‐derived therapies, this study aims to compare the angiogenic and immunomodulatory potentials and the protein and miRNA cargo compositions of EVs isolated from the two most common clinical sources of adult MSCs, bone marrow and adipose tissue, across different passage numbers. Primary bone marrow‐derived MSCs (BMSCs) and adipose‐derived MSCs (ASCs) were isolated from adult female Lewis rats and expanded in vitro to the indicated passage numbers (P2, P4, and P8). EVs were isolated from the culture medium of P2, P4, and P8 BMSCs and ASCs and characterized for EV size, number, surface markers, protein content, and morphology. EVs isolated from different tissue sources showed different EV yields per cell, EV sizes, and protein yield per EV. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of proteomics data and miRNA seq data identified key proteins and pathways associated with differences between BMSC‐EVs and ASC‐EVs, as well as differences due to passage number. In vitro tube formation assays employing human umbilical vein endothelial cells suggested that both tissue source and passage number had significant effects on the angiogenic capacity of EVs. With or without lipopolysaccharide (LPS) stimulation, EVs more significantly impacted expression of M2‐macrophage genes (IL‐10, Arg1, TGFβ) than M1‐macrophage genes (IL‐6, NOS2, TNFα). By correlating the proteomics analyses with the miRNA seq analysis and differences observed in our in vitro immunomodulatory, angiogenic, and proliferation assays, this study highlights the trade‐offs that may be necessary in selecting the optimal MSC source for development of clinical EV therapies.
サーキット場で生じた車両事故による外傷の特徴(Characteristics of traumatic injuries resulting from vehicle accidents occurring at a racing circuit)
Authors: 一樹 菅谷 , 智史 上野 , 友誉 三澤 , 剛 鈴木 , 誠 小野寺 , 憲 伊関 
Published: August 2024

要旨【目的】本邦には数多くのサーキット場があるが，サーキット場で発生した車両事故による外傷（以下，サーキット外傷）に関する疫学的調査は不足している。本研究はサーキット外傷の疫学的特徴を明らかにすることを目的とした。【方法】2013年から2022年までに，エビスサーキットを救急要請地点として要請された傷病者を後方視的に検討した。【結果】期間内に87件の救急要請があり，54人が三次医療機関である当院に搬送され，そのうち49人がサーキット外傷であった。ドクターヘリかドクターカーで搬送されたサーキット外傷は21人であった。サーキット外傷患者の特徴は，平均年齢39.2歳，男性45人であった。車両種別は二輪車30人，四輪車17人，自転車2人であった。部位別では，二輪車であれば四肢外傷や体表外傷が多く，AISは頭頚部が高値で，四輪車は胸部や体表の外傷が多く，AISは腹部が高値であった。5人が帰宅した。9人が受傷から24時間以内に全身麻酔下で手術を受けた。全種目の合計のinjury severity scoreの中央値は9であったが，大半の患者は生理学的に安定しており，probability of survivalが50%以下の症例は3例のみで，46例は90%以上であった。期間中に2人が死亡した。【結語】サーキット外傷は，二輪車では四肢外傷が，四輪車では胸部外傷が多く，いずれも生理学的に安定していた。