bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing hemostasis in HoLEP surgery: retrospective review of selective bipolar plasmakinetic technology guided by bladder irrigation fluid color
Authors: Hu Hengda , Chen Wenpu , Ma Weixiong , Yu Chengshuai , He Qirui , Tang Jinrong , Yu Guofeng 
Published: July 2024

Abstract
Object
To evaluate the effectiveness of selective bipolar plasmakinetic technology based on bladder irrigation fluid color on hemostasis in HoLEP surgwery

Methods
A total of 209 patients who underwent HoLEP surgery from October 2021 to July 2023 were included and divided into Hemostasis Management Group and control group. the color of the irrigation fluid was categorized into 5 levels and the bipolar plasmakinetic technology was applied when the color came to level 4 or up. The following was analyzed: postoperative use of balloon compression, blood loss, irrigation time, length of hospital stay, and the number of a second operation.

Results
Only 4 patients in Hemostasis Management Group required postoperative urinary catheter balloon compression, while there are 15 in the control group(p=0.03). The average irrigation time for patients in the HM Group with bipolar plasmakinetic hemostasis was 21.88±13.76 hours, compared to that in patients with catheter balloon compression(p=0.007).

Conclusion
Based on the bladder irrigation color chart, the selective application of bipolar plasmakinetic hemostasis led to a significant reduction in the number of patients requiring postoperative bladder catheter balloon compression. Secondly, the irrigation time of patients who underwent bipolar plasmakinetic hemostasis also decreased.
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome
Authors: Kasri Amal , Camporesi Elena , Gkanatsiou Eleni , Boluda Susana , Brinkmalm Gunnar , Stimmer Lev , Ge Junyue , Hanrieder Jörg , Villain Nicolas , Duyckaerts Charles , Vermeiren Yannick , Pape Sarah E. , Nicolas Gaël , Laquerrière Annie , De Deyn Peter Paul , Wallon David , Blennow Kaj , Strydom Andre , Zetterberg Henrik , Potier Marie-Claude 
Published: July 2024

AbstractAlzheimer’s disease (AD) is characterized by extracellular amyloid plaques containing amyloid-β (Aβ) peptides, intraneuronal neurofibrillary tangles, extracellular neuropil threads, and dystrophic neurites surrounding plaques composed of hyperphosphorylated tau protein (pTau). Aβ can also deposit in blood vessel walls leading to cerebral amyloid angiopathy (CAA). While amyloid plaques in AD brains are constant, CAA varies among cases. The study focuses on differences observed between rare and poorly studied patient groups with APP duplications (APPdup) and Down syndrome (DS) reported to have higher frequencies of elevated CAA levels in comparison to sporadic AD (sAD), most of APP mutations, and controls. We compared Aβ and tau pathologies in postmortem brain tissues across cases and Aβ peptides using mass spectrometry (MS). We further characterized the spatial distribution of Aβ peptides with MS-brain imaging. While intraparenchymal Aβ deposits were numerous in sAD, DS with AD (DS-AD) and AD with APP mutations, these were less abundant in APPdup. On the contrary, Aβ deposits in the blood vessels were abundant in APPdup and DS-AD while only APPdup cases displayed high Aβ deposits in capillaries. Investigation of Aβ peptide profiles showed a specific increase in Aβx-37, Aβx-38 and Aβx-40 but not Aβx-42 in APPdup cases and to a lower extent in DS-AD cases. Interestingly, N-truncated Aβ2-x peptides were particularly increased in APPdup compared to all other groups. This result was confirmed by MS-imaging of leptomeningeal and parenchymal vessels from an APPdup case, suggesting that CAA is associated with accumulation of shorter Aβ peptides truncated both at N- and C-termini in blood vessels. Altogether, this study identified striking differences in the localization and composition of Aβ deposits between AD cases, particularly APPdup and DS-AD, both carrying three genomic copies of the APP gene. Detection of specific Aβ peptides in CSF or plasma of these patients could improve the diagnosis of CAA and their inclusion in anti-amyloid immunotherapy treatments.
The highest work rate associated with a predominantly aerobic contribution coincides with the highest work rate at which VO2max can be attained
Authors: Peker Arda , As Hakan , Kaya Erkutay , Balci Gorkem Aybars , Ozkaya Ozgur 
Published: July 2024

Abstract
Purpose
To estimate the highest power output at which predominant energy contribution is derived from the aerobic system (aerobic limit power: ALP) and to compare ALP with the upper boundary of the severe intensity exercise domain.

Methods
Fifteen male individuals participated in this study. The upper boundary was estimated using i) linear relationship between time to achieve $$\dot{\text{V}}$$

V
˙

O2max and time to task failure (PUPPERBOUND), ii) hyperbolic relationships between time to achieve $$\dot{\text{V}}$$

V
˙

O2max vs. power output, and time to task failure vs. power output (PUPPERBOUND´), and iii) precalculated $$\dot{\text{V}}$$

V
˙

O2max demand (IHIGH). ALP was estimated by aerobic, lactic, and phospholytic energy contributions using $$\dot{\text{V}}$$

V
˙

O2 response, blood [lactate] response, and fast component of recovery $$\dot{\text{V}}$$

V
˙

O2 kinetics, respectively.

Results
ALP was determined as the highest power output providing predominant aerobic contribution; however, anaerobic pathways became the predominant energy source when ALP was exceeded by 5% (ALP + 5%) (from 46 to 52%; p = 0.003; ES:0.69). The $$\dot{\text{V}}$$

V
˙

O2 during exercise at ALP was not statistically different from $$\dot{\text{V}}$$

V
˙

O2max (p > 0.05), but $$\dot{\text{V}}$$

V
˙

O2max could not be attained at ALP + 5% (p < 0.01; ES:0.63). ALP was similar to PUPPERBOUND and PUPPERBOUND´ (383 vs. 379 and 384 W; p > 0.05). There was a close agreement between ALP and PUPPERBOUND (r: 0.99; Bias: − 3 W; SEE: 6 W; TE: 8 W; LoA: − 17 to 10 W) and PUPPERBOUND´ (r: 0.98; Bias: 1 W; SEE: 8 W; TE: 8 W; LoA: − 15 to 17 W). ALP, PUPPERBOUND, and PUPPERBOUND´ were greater than IHIGH (339 ± 53 W; p < 0.001).

Conclusion
ALP may provide a new perspective to intensity domain framework.
Early and delayed periprosthetic joint infection in robot-assisted total knee arthroplasty: a multicenter study
Authors: Burgio Carmelo , Bosco Francesco , Rovere Giuseppe , Giustra Fortunato , Lo Bue Giorgia , Petillo Antonio , Lucenti Ludovico , Palumbo Gaetano , Camarda Lawrence 
Published: July 2024

Abstract
Background
Robot-assisted total knee arthroplasty (RA-TKA) has significantly improved knee surgery outcomes in the last few years. However, its association with the periprosthetic joint infection (PJI) rate remains debatable. This study investigates the incidence of early and delayed PJI in a multicentric cohort of patients who underwent RA-TKA, aiming to elucidate the risk associated with this procedure.

Methods
This retrospective study analyzed data from a consecutive series of patients who underwent RA-TKA using the NAVIO Surgical System (Smith & Nephew, Memphis, USA) between 2020 and 2023. The inclusion criteria encompassed individuals over 18 years of age with a minimum follow-up period of three months. The primary outcome was the incidence of early and delayed PJI, defined according to the European Bone and Joint Infection Society (EBJIS) diagnostic criteria. Secondary outcomes included the evaluation of postoperative complications.

Results
The study included patients who underwent RA-TKA with the NAVIO system, achieving an average follow-up of 9.1 ± 3.9 months. None of the patients met the EBJIS criteria for a likely or confirmed infection, indicating an absence of both early and delayed PJI cases. Two patients required subsequent surgical interventions due to patellar maltracking and prosthetic loosening, respectively. Additionally, three patients underwent passive manipulation under anesthesia (MUA).

Conclusion
The findings indicate no evidence of early or delayed PJI in patients undergoing RA-TKA within the study period. The low complication rate further supports the reliability and safety of this surgical technique in short-term follow-up.

Level of evidence
IV.
Differentiated metabolomic profiling reveals plasma amino acid signatures for primary glomerular disease
Authors: Wang Jiao , Zhou Chunyu , Lu Liqian , Wang Shoujun , Zhang Qing , Liu Zhangsuo 
Published: July 2024

AbstractPrimary glomerular disease (PGD) is an idiopathic cause of renal glomerular lesions that is characterized by proteinuria or hematuria and is the leading cause of chronic kidney disease (CKD). The identification of circulating biomarkers for the diagnosis of PGD requires a thorough understanding of the metabolic defects involved. In this study, ultra-high performance liquid chromatography–tandem mass spectrometry was performed to characterize the amino acid (AA) profiles of patients with pathologically diagnosed PGD, including minimal change disease (MCD), focal segmental glomerular sclerosis (FSGS), membranous nephropathy, and immunoglobulin A nephropathy. The plasma concentrations of asparagine and ornithine were low, and that of aspartic acid was high, in patients with all the pathologic types of PGD, compared to healthy controls. Two distinct diagnostic models were generated using the differential plasma AA profiles using logistic regression and receiver operating characteristic analyses, with areas under the curves of 1.000 and accuracies up to 100.0% in patients with MCD and FSGS. In conclusion, the progression of PGD is associated with alterations in AA profiles, The present findings provide a theoretical basis for the use of AAs as a non-invasive, real-time, rapid, and simple biomarker for the diagnosis of various pathologic types of PGD.
Kufor-Rakeb syndrome-associated psychosis: a novel loss-of-function ATP13A2 variant and response to antipsychotic therapy
Authors: Colijn Mark Ainsley , Vrijsen Stephanie , Au Ping Yee Billie , Abou El Asrar Rania , Houdou Marine , Van den Haute Chris , Sarna Justyna , Montgomery Greg , Vangheluwe Peter 
Published: July 2024

AbstractBiallelic (autosomal recessive) pathogenic variants in ATP13A2 cause a form of juvenile-onset parkinsonism, termed Kufor-Rakeb syndrome. In addition to motor symptoms, a variety of other neurological and psychiatric symptoms may occur in affected individuals, including supranuclear gaze palsy and cognitive decline. Although psychotic symptoms are often reported, response to antipsychotic therapy is not well described in previous case reports/series. As such, we describe treatment response in an individual with Kufor-Rakeb syndrome-associated psychosis. His disease was caused by a homozygous novel loss-of-function ATP13A2 variant (NM_022089.4, c.1970_1975del) that was characterized in this study. Our patient exhibited a good response to quetiapine monotherapy, which he has so far tolerated well. We also reviewed the literature and summarized all previous descriptions of antipsychotic treatment response. Although its use has infrequently been described in Kufor-Rakeb syndrome, quetiapine is commonly used in other degenerative parkinsonian disorders, given its lower propensity to cause extrapyramidal symptoms. As such, quetiapine should be considered in the treatment of Kufor-Rakeb syndrome-associated psychosis when antipsychotic therapy is deemed necessary.
The Emotion Authenticity Recognition (EAR) test: normative data of an innovative test using dynamic emotional stimuli to evaluate the ability to recognize the authenticity of emotions expressed by faces
Authors: Scarpazza Cristina , Gramegna Chiara , Costa Cristiano , Pezzetta Rachele , Saetti Maria Cristina , Preti Alice Naomi , Difonzo Teresa , Zago Stefano , Bolognini Nadia 
Published: July 2024

AbstractDespite research has massively focused on how emotions conveyed by faces are perceived, the perception of emotions’ authenticity is a topic that has been surprisingly overlooked. Here, we present the Emotion Authenticity Recognition (EAR) test, a test specifically developed using dynamic stimuli depicting authentic and posed emotions to evaluate the ability of individuals to correctly identify an emotion (emotion recognition index, ER Index) and classify its authenticity (authenticity recognition index (EA Index). The EAR test has been validated on 522 healthy participants and normative values are provided. Correlations with demographic characteristics, empathy and general cognitive status have been obtained revealing that both indices are negatively correlated with age, and positively with education, cognitive status and different facets of empathy. The EAR test offers a new ecological test to assess the ability to detect emotion authenticity that allow to explore the eventual social cognitive deficit even in patients otherwise cognitively intact.
Reduced fitness in losers of leg-biting male combat compared to uncontested males in Zophobas atratus
Authors: Matsuura Teruhisa , Miyatake Takahisa 
Published: July 2024

AbstractSexual dimorphism and male combat are observed in many species. Often, the outcome of male combat affects the outcome of subsequent combats, mating success, number of sperm, and fitness of the male’s offspring. Also, the quantity and quality of sperm may be regulated by winning or losing, depending on species ecology and mating system. However, very few studies have experimentally examined the influence of fight outcomes on male offspring fitness. We studied male combat in the giant mealworm (Zophobas atratus) in which males bite each other’s hind legs. We hypothesized that subsequent fitness could differ between winners and losers in the escalated male combat of this species. We measured several fitness traits including the number of eggs laid by mated females, and the number of hatches sired by uncontested males, winners, and losers in escalated and non-escalated combat, and compared the fitness of each winner and loser to that of an uncontested male. We also measured mating duration. The numbers of eggs and the percentages of hatched eggs of losers in the escalated combat were significantly reduced compared to that of the uncontested males. This reduction may be due to injuries from escalated leg- biting fights and a result of the sperm amount of the uncontested males being greater than that of the loser males.
Exploring necrosis-associated mitochondrial gene signatures: revealing their role in prognosis and immunotherapy of renal clear cell carcinoma
Authors: Wang Zhipeng , Zheng Fuchun , Wei Shiliang , Li Sheng , Xiong Situ , Zhang Lei , Wan Liangwei , Xu Songhui , Deng Jun , Liu Xiaoqiang 
Published: July 2024

AbstractMitochondrial dysfunction and necrotic apoptosis, pivotal in therapeutic strategies for multiple diseases, lack comprehensive understanding in the context of renal clear cell carcinoma (ccRCC). This study explores their potential as valuable tools for ccRCC prediction, prevention, and personalized medical care. Transcriptomic and clinical datasets were acquired from the Cancer Genome Atlas (TCGA) repository. Mitochondrial and necrosis-associated gene sets were sourced from MitoCarta3.0 and the KEGG Pathway databases, respectively. Six necrosis-related mitochondrial genes (nc-MTGs) with prognostic significance were analyzed and screened, and a prognostic model was constructed. The accuracy of the model was verified using external data (E-MTAB-1980). TISCH was used to explore nc-MTGs at the cellular level. Finally, the expression level of BH3 interacting domain death agonist (BID) in ccRCC cell line was detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), and the effect of BID down-regulation on tumor cell migration was verified by transwell assays and wound-healing experiments. We established and validated a prognostic model for clear cell renal cell carcinoma (ccRCC) utilizing six necrosis-related mitochondrial genes (nc-MTGs), affirming its efficacy in evaluating tumor progression. RT-PCR results showed that BID expression was up-regulated in ccRCC tissues compared with controls and exhibited oncogenic effects. In vitro cell function experiments showed that BID may be an important factor affecting the migration of ccRCC. Our study is the first to elucidate the biological functions and prognostic significance of mitochondrial molecules related to necroptosis, providing a new way to evaluate mitochondrial therapeutics in patients with ccRCC.
The influence of heavy metals on cytotoxicity in Tilapia zillii
Authors: Abass Nermeen Y. 
Published: July 2024

AbstractThe present study was designed to investigate the cytotoxic effects and bioaccumulation of heavy metals iron (Fe), zinc (Zn), copper (Cu), cadmium (Cd), lead (Pb), manganese (Mn), nickel (Ni), and chromium (Cr) in different parts (muscle, gills, and liver) of Tilapia zillii occurring in polluted drainage canal and fish farm, which is located in Abiece region in front of village number 10, Alexandria governorate, Egypt. Results of water analysis revealed the concentration of Cd, Pb, Mn, Ni, and Cr exceeded the limits defined by the American Public Health Association (APHA) in the polluted drainage canal. In addition, the concentration of Ni elevated to the standard limits of APHA and Cu was not detected in the fish farm. Different types of chromosomal aberrations were recorded (e.g., stickiness, fragmented chromosomes, centromeric gaps, chromatid break, chromatid deletion, and tetraploid). Micronucleus frequency was found to be 5.58 in the polluted drainage canal group and 0.32 in the fish farm group. Other nuclear abnormalities such as blebbed nucleus, segmented nucleus, enucleated erythrocyte, kidney-shaped nucleus, heart-shaped nucleus, polymorphic irregular nuclei, binucleated cell, nuclear fragmented erythrocyte, long nucleus, putative fragmented notched nucleus, lobed nuclei, fused erythrocytes, necrotic erythrocyte, and vacuolated nucleus were recorded. The total of erythrocytes nuclear morphological abnormalities was 70.33% in the polluted drainage canal and 1.78% in the fish farm.
A Qualitative Content Analysis of Perceived Individual and Relational Consequences of Sexual Compliance and Their Contributors
Authors: Gunst Annika , Alanko Katarina , Nickull Sabina , Dewitte Marieke , Källström Marianne , Antfolk Jan , Jern Patrick 
Published: July 2024

AbstractSexual compliance (i.e., consensually engaging in sex despite a lack of desire for it) is common in committed intimate relationships, but the consequences of compliance for the well-being of the individual and the relationship are poorly understood. We investigated the perceived consequences of sexual compliance and perceptions of factors contributing to negative/positive consequences by applying qualitative content analysis to free-text retrospective survey responses from 107 (mostly) Finnish adults. We identified five themes of personal consequences (emotions and mood, sexual experience, sexual desire, pressure and violations, and physical pain), four of relational consequences (relationship satisfaction, partner’s response, relationship interaction, and value alignment), and nine of possible factors contributing to negative/positive consequences (communication, self-esteem, motives for sex, relationship factors, agency and self-knowledge, mental health and stress, psychological flexibility, societal norms, and past negative experiences). Perceived consequences varied widely across individuals, both in terms of whether any positive or negative consequences were experienced and whether compliance was perceived as improving or worsening specific domains of well-being. We discuss the themes identified in relation to previous theories of sexuality and intimate relationships and offer hypotheses that can be tested in future quantitative studies.
How different is different? Systematically identifying distribution shifts and their impacts in NER datasets
Authors: Li Xue , Groth Paul 
Published: July 2024

AbstractWhen processing natural language, we are frequently confronted with the problem of distribution shift. For example, using a model trained on a news corpus to subsequently process legal text exhibits reduced performance. While this problem is well-known, to this point, there has not been a systematic study of detecting shifts and investigating the impact shifts have on model performance for NLP tasks. Therefore, in this paper, we detect and measure two types of distribution shift, across three different representations, for 12 benchmark Named Entity Recognition datasets. We show that both input shift and label shift can lead to dramatic performance degradation. For example, fine-tuning on a wide spectrum dataset (OntoNotes) and testing on an email dataset (CEREC) that shares labels leads to a 63-points drop in F1 performance. Overall, our results indicate that the measurement of distribution shift can provide guidance to the amount of data needed for fine-tuning and whether or not a model can be used “off-the-shelf” without subsequent fine-tuning. Finally, our results show that shift measurement can play an important role in NLP model pipeline definition.
Population genetic structure of the European pond turtle (Emys orbicularis) at the northern edge of the Pannonian Basin
Authors: Mikulíček Peter , Papežík Petr , Danko Stanislav , Dankovics Róbert , Gruľa Daniel , Halpern Bálint , Havaš Peter , Heltai Botond , Horváth Enikő , Kušík Tomáš , Puchala Peter , Schindler Maria , Vongrej Viliam , Uhrin Marcel 
Published: July 2024

AbstractPopulations of plants and animals at the edge of a species’ range may exhibit lower genetic diversity due to a combination of historical (e.g., postglacial dispersal) and contemporary (e.g., low effective population size, strong genetic drift or bottlenecks) processes. In this study, we analysed the genetic structure of populations of the European pond turtle (Emys orbicularis) in the northern part of the Pannonian Basin (Slovakia, Hungary, Austria), which represents the edge of the species’ range. Using mitochondrial DNA (mtDNA) and microsatellite markers, we aimed to assign individuals and populations into phylogeographic lineages and to determine genetic variation and population structure. Our study revealed that most individuals from natural populations belong to mtDNA lineage II (widely distributed haplotype IIa, and likely endemic haplotypes IIl and IIo), which is typical for the whole Pannonian region. However, non-native haplotypes were detected in one Slovak population (haplotype Ib) and in the Austrian Donau Auen National Park (haplotype IVa). Microsatellite markers revealed high variability comparable to that in other parts of the range, suggesting that marginal populations may not necessarily have reduced genetic diversity. A genetically mixed population was found in the Donau Auen National Park, consisting of turtles belonging to mtDNA lineage II (taxonomically assessed as subspecies E. orbicularis orbicularis) and lineage IV (taxonomically assessed as E. orbicularis hellenica), which is native to the circum-Adriatic region. The admixture suggests intense hybridization and introgression between the two lineages (subspecies).