bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of stress on periodontal treatment: a longitudinal investigation using clinical and biological markers
Authors: Bakri Issam , Douglas Charles W. Ian , Rawlinson Andrew 
Published: July 2013

AbstractAimTo investigate the effects of psychosocial stress on the outcome of non‐surgical periodontal treatment (NPT).MethodsPatients were categorized as stressed or unstressed, and the degree of stress was measured. One deep bleeding and one deep non‐bleeding site ≥6 mm were selected in each patient for detailed investigation, and the clinical parameters were recorded before and at 6 months after NPT. Elastase and C‐terminal teleopeptide of type I collagen (ICTP) were measured in gingival crevicular fluid (GCF) samples at both intervals.ResultsThe baseline, clinical parameters and biological markers were similar in both stressed and unstressed groups, other than for GCF elastase levels, which were significantly higher in the stressed group of patients (p < 0.05). The effect of stress on the changes for clinical measurements and elastase levels in GCF was statistically significant for deep bleeding sites, with the response to treatment being poorer in the stressed group. The effects of smoking and the degree of stress were not statistically significant for any of the clinical or biological parameters (p > 0.05).ConclusionsPatients under psychosocial stress had a poorer outcome following NPT. The assessment of psychosocial stress may be valuable in the holistic management of periodontal disease.
Alcohol consumption and psoriasis: a systematic literature review
Authors: Brenaut E. , Horreau C. , Pouplard C. , Barnetche T. , Paul C. , Richard M.‐A. , Joly P. , Le Maître M. , Aractingi S. , Aubin F. , Cribier B. , Jullien D. , Ortonne J.‐P. , Misery L. 
Published: July 2013

AbstractThe association between alcohol consumption and psoriasis has been frequently discussed since the 1980s, but no systematic review has been elaborated on the subject so far.The aim of this systematic literature review was to assess whether alcohol consumption is more prevalent in psoriasis patients than in the general population and whether alcohol consumption is a risk factor of psoriasis.A systematic literature search was carried out in the Medline, Embase and Cochrane databases using the keywords ‘psoriasis’ AND ‘alcohol drinking’ OR ‘alcohol‐related disorders’. The search was then enlarged with the keywords ‘psoriasis’ AND ‘risk factor’ OR ‘comorbidity’.Altogether 911 references in English and French were found. Out of these, 837 articles were excluded by reading the abstract and 46 by reading the article. A total of 28 articles were selected. Alcohol consumption in psoriasis patients versus the general population: 23 studies were selected; 18 concluded that alcohol consumption was more prevalent in psoriasis patients, and 5 did not. Three studies compared the prevalence of excessive drinking using a questionnaire on alcohol dependence (CAGE or Self‐administered alcohol screening test (SAAST)) or with quantitative criteria for excessive drinking. In these studies, excessive drinking was more prevalent among psoriasis patients than in the general population. Other articles studied the quantity and type of alcohol consumed. In 11 studies, psoriasis patients consumed more alcohol than the controls. Four other studies showed excessive alcohol consumption in psoriasis patients without control group comparison. Conversely, five studies identified no difference in alcohol consumption between psoriasis patients and the general population. The heterogeneity in the measurement of alcohol consumption did not allow performing meta‐analysis. Alcohol as a risk factor for psoriasis: only five studies were selected. In four of these studies alcohol was found to be a risk factor for psoriasis.Alcohol consumption seems to be greater in psoriasis patients than in the general population. However, there is not enough evidence to establish whether alcohol consumption is indeed a risk factor for psoriasis.
Risk of cancer in psoriasis: a systematic review and meta‐analysis of epidemiological studies
Authors: Pouplard C. , Brenaut E. , Horreau C. , Barnetche T. , Misery L. , Richard M.‐A. , Aractingi S. , Aubin F. , Cribier B. , Joly P. , Jullien D. , Le Maître M. , Ortonne J.‐P. , Paul C. 
Published: July 2013

AbstractThe relationship between psoriasis and increased cancer risk is debated.The aim of this study was to evaluate if there is an increase in the background risk of cancer in psoriasis patients compared with the general population.A systematic literature search was performed on PubMed, Embase and Cochrane databases, using the keywords ‘Psoriasis [Majr] AND Neoplasms’, from 1980 to January 2012. Meta‐analysis was performed based on observational studies showing consistency in cancer risk assessment methods.Of the 1080 articles retrieved, 37 references were selected. There may be an increased risk of some solid cancers in psoriasis: respiratory tract cancer [standardized incidence ratio (SIR) = 1.52, 95% confidence interval (CI) 1.35–1.71], upper aerodigestive tract cancer (SIR = 3.05, 95% CI 1.74–5.32), urinary tract cancer (SIR = 1.31, 95% CI 1.11–1.55) and liver cancer (SIR = 1.90, 95% CI 1.48–2.44). The risk of non‐Hodgkin lymphoma appears slightly increased in psoriasis (SIR = 1.40, 95% CI 1.06–1.86). Psoriasis patients have an increased risk of squamous cell carcinoma (SIR = 5.3, 95% CI 2.63–10.71) and basal cell carcinoma (SIR = 2.00, 95% CI 1.83–2.20), whereas the risk of melanoma is not increased.There was a large heterogeneity in studies assessing cancer risk in psoriasis preventing from including all studies in meta‐analysis.This systematic literature review shows a small increased risk of some solid cancers in psoriasis, especially those linked to alcohol drinking and cigarette smoking. A higher risk of non‐melanoma skin cancers, especially squamous cell carcinoma, is shown, mainly due to previous exposure to 8‐methoxypsoralen‐ultraviolet‐A (PUVA), ciclosporin and possibly methotrexate.
Inferring signalling networks from images
Authors: EVANS L. , SAILEM H. , VARGAS P. PASCUAL , BAKAL C. 
Published: July 2013

SummaryThe mapping of signalling networks is one of biology's most important goals. However, given their size, complexity and dynamic nature, obtaining comprehensive descriptions of these networks has proven extremely challenging. A fast and cost‐effective means to infer connectivity between genes on a systems‐level is by quantifying the similarity between high‐dimensional cellular phenotypes following systematic gene depletion. This review describes the methodology used to map signalling networks using data generated in the context of RNAi screens.
Noninvasive fluorescence imaging of small animals
Authors: ZELMER A. , WARD T.H. 
Published: July 2013

SummaryNoninvasive in vivo fluorescence imaging of small animals as a method in preclinical research has developed considerably in recent years, and is used widely across a variety of disciplines such as oncology and infectious disease research. It provides a means of detecting a fluorescent signal within a living animal reflecting specific, mostly disease‐related, processes, such as parts of the host immune response, inflammation, cancer growth or presence of pathogens. As well as offering many advantages as a standalone technique, it can also be highly complementary to other imaging modalities. This review discusses aspects of light distribution in animal tissue and the implications on in vivo imaging; the most widely used imaging techniques including planar and tomographic imaging; advantages and challenges of the techniques; fluorescent contrast agents and some examples of applications. Rather than in detail reviewing studies using in vivo fluorescence imaging, we focus on the principles and practicalities of the method itself, so that the reader can apply these to their own research question.
Experimental investigation of parents and their children's social interaction intentions towards obese children
Authors: Wolfenden Luke , McKeough Alyce , Bowman Jennifer , Paolini Stefania , Francis Lynn , Wye Paula , Puhl Rebecca 
Published: July 2013

AimThe aim of this study was to determine if parent intentions to facilitate social interactions between their child and a peer, or parental perceptions of their child's peer social interaction intentions, differ according to the weight status of a child's peer.MethodsDuring a telephone survey, 250 Australian parents of children 5–12 years were randomly assigned to listen to one of two descriptions of a hypothetical child differing by group in the description of child weight status (‘quite overweight’ or ‘healthy weight’). Parents then completed the Social Interaction Intention Scale, which assessed how likely they or their child would engage in a number of behaviours that may facilitate social interaction with the child described in the profile.ResultsMeans scores on the overall scale and the child sub‐scale of the Child Social Interaction Intention Scale were significantly higher among participants allocated to the healthy weight child profile, indicating more positive social intentions.ConclusionThe findings suggest that negative weight‐based stereotypes hinder the development of peer friendships by obese children.
Resource translocation drives 13C fractionation during recovery from disturbance in giant kelp, Macrocystis pyrifera
Authors: Fox Michael D. 
Published: July 2013

Resource allocation and translocation are fundamental physiological functions for autotrophs. The mobilization and use of resources drive population dynamics by regulating growth and recovery of individuals, but also influences ecosystem‐level processes such as primary productivity and carbon cycling. This study provides the first observation of translocation‐driven gradients of δ13C in macroalgae, a critically important phenomenon recognized in vascular plants for decades. A ~10‰ δ13C increase in new giant kelp (Macrocystis pyrifera) fronds relative to mature canopy blades was produced after 5 weeks following a biomass removal experiment, more than twice the variation typical for macroalgae. The observed δ13C patterns are consistent with tissue enrichment following resource translocation in vascular plants. The analogous source‐sink relationships and consistent translocation patterns in Macrocystis and vascular plants suggest that translocation of stored resources is critical for structuring productivity and recovery from disturbance in important, habitat‐forming macroalgae such as kelps and fucoids.
Efficacy and Safety of Dapoxetine in Men with Premature Ejaculation and Concomitant Erectile Dysfunction Treated with a Phosphodiesterase Type 5 Inhibitor: Randomized, Placebo-Controlled, Phase III Study
Authors: McMahon Chris G. , Giuliano Francois , Dean John , Hellstrom Wayne J.G. , Bull Scott , Tesfaye Fisseha , Sharma Om , Rivas David A. , Aquilina Joseph W. 
Published: July 2013

ABSTRACT

Introduction
Men with comorbid erectile dysfunction (ED) and premature ejaculation (PE) may be concomitantly prescribed a phosphodiesterase type 5 (PDE5) inhibitor and dapoxetine.

Aim
Evaluate efficacy and safety of dapoxetine 30mg and 60mg on demand (prn) in men with PE and ED who were being treated with PDE5 inhibitors.

Methods
This randomized, double-blind, placebo-controlled, flexible-dose, multicenter study enrolled men ≥18 years who met diagnostic criteria for PE including intravaginal ejaculatory latency time (IELT) of ≤2 minutes in ≥75% of sexual intercourse episodes; were on stable regimen of a PDE5 inhibitor; and had International Index of Erectile Function-erectile function domain score ≥21. Subjects received placebo, dapoxetine 30mg, or dapoxetine 60mg prn (1–3 hours before intercourse) for 12 weeks.

Main Outcome Measure
Stopwatch-measured average IELT, Clinical Global Impression of Change (CGIC) in PE, Premature Ejaculation Profile (PEP), and treatment-emergent adverse events (TEAEs).

Results
Of 495 subjects randomized, 429 completed the study. Arithmetic mean average IELT significantly increased with dapoxetine vs. placebo at end point (5.2 vs. 3.4 minutes) and weeks 4, 8, and 12 (P ≤0.002 for all). Men who described their PE at least “better” using the CGIC were significantly greater with dapoxetine vs. placebo at end point (56.5% vs. 35.4%) and weeks 4, 8, and 12 (P ≤0.001 for all). Significantly better outcomes were also reported with dapoxetine vs. placebo on PEP measures. Incidence of TEAEs was 20.0% and 29.6% in placebo- and dapoxetine-treated subjects, respectively (P =0.0135). TEAEs led to discontinuation in 1.6% of subjects in both groups. Most frequent TEAEs were known adverse drug reactions of dapoxetine treatment including nausea (9.2%), headache (4.4%), diarrhea (3.6%), dizziness (2.4%), and dizziness postural (2.4%).

Conclusions
In men with PE and comorbid ED on a stable regimen of PDE5 inhibitor, dapoxetine provided meaningful treatment benefit and was generally well tolerated.
Aspects of Sexual Self-Schema in Premenopausal Women with Dyspareunia: Associations with Pain, Sexual Function, and Sexual Distress
Authors: Pazmany Els , Bergeron Sophie , Van Oudenhove Lukas , Verhaeghe Johan , Enzlin Paul 
Published: July 2013

ABSTRACT

Introduction
Although it is known that women with dyspareunia suffer from impaired psychological and sexual functioning, the study of the various dimensions of sexual self-schema and their associations with these outcomes has been neglected.

Aim
To examine whether self-image cognitions about vaginal penetration, body image, and feelings and beliefs about one's own genitals contribute to the variance in pain, sexual functioning, and sexual distress.

Methods
Premenopausal women (n=231; M age=24.85, SD=5.55) with self-reported dyspareunia completed an online survey focusing on self-image cognitions about vaginal penetration, body image, female genital self-image, pain during intercourse, sexual functioning, sexual distress, anxiety, and catastrophizing.

Main Outcome Measures
(i) Pain intensity during intercourse, (ii) the Female Sexual Function Index without the Pain subscale, and (iii) the Female Sexual Distress Scale.

Results
Controlling for anxiety and catastrophizing, negative self-image cognitions about vaginal penetration, negative body image, and negative genital self-image together accounted for a portion of the variance in increased pain intensity, sexual dysfunction, and sexual distress. However, only self-image cognitions about vaginal penetration (β=0.25, P =0.005) contributed uniquely to the variance in pain intensity, whereas self-image cognitions about vaginal penetration (β=−0.18, P =0.048) and genital self-image (β=0.21, P =0.008) contributed independently to the variance in sexual functioning. Finally, self-image cognitions about vaginal penetration (β=0.28, P &lt;0.001), body image (β=0.24, P &lt;0.001) and genital self-image (β=−0.14, P =0.006) each contributed independently to the variance in sexual distress.

Conclusions
Findings suggest that self-image cognitions about vaginal penetration and feelings and beliefs about one's own body and genitals are associated with pain and sexuality outcomes in women with dyspareunia.
Relationship of Testis Size and LH Levels with Incidence of Major Adverse Cardiovascular Events in Older Men with Sexual Dysfunction
Authors: Rastrelli Giulia , Corona Giovanni , Lotti Francesco , Boddi Valentina , Mannucci Edoardo , Maggi Mario 
Published: July 2013

ABSTRACT

Introduction
Measurement of testis volume (TV) is a reliable clinical procedure that predicts reproductive fitness. However, the role of TV in overall and cardiovascular (CV) fitness has never been studied.

Aim
The study aims to analyze the clinical correlates of TV in patients with sexual dysfunction (SD) and to verify the value of this parameter and its determinants (i.e., luteinizing hormone [LH] levels) in predicting major adverse CV events (MACE).

Methods
A consecutive series of 2,809 subjects without testiculopathy (age 51.2 ± 13.1) consulting for SD was retrospectively studied. A subset of this sample (n = 1,395) was enrolled in a longitudinal study.

Main Outcome Measures
Several clinical and biochemical parameters were investigated.

Results
After adjusting for confounders, TV was negatively associated with both LH (Adj. r = −0.234; P &lt; 0.0001) and follicle-stimulating hormone (Adj. r = −0.326; P &lt; 0.0001). In addition, overweight/obesity, smoking, and alcohol abuse increased as a function of TV (hazard ratio [HR] = 1.041 [1.021–1.061], P &lt; 0.0001; 1.024 [1.005–1.044], P = 0.012; 1.063 [1.015–1.112], P = 0.009, respectively). Furthermore, mean blood pressure was positively related to increased TV (Adj. r = 0.157; P &lt; 0.0001). The effect of these lifestyle factors on TV were only partially related to changes in gonadotropin levels. In the longitudinal analysis, after adjusting for confounders, TV was associated with a higher incidence of MACE (HR = 1.066 [1.013–1.122]; P = 0.014), and the stepwise introduction in the Cox model of lifestyle factors, mean blood pressure and body mass index progressively smoothed out the association, which was no longer statistically significant in the fully adjusted model. Conversely, the association of higher LH levels with increased incidence of MACE was not attenuated by the progressive introduction of the aforementioned confounders in the model.

Conclusions
Our data show that in SD subjects, TV and LH are associated with an adverse CV risk profile that mediate the higher TV-associated incidence of MACE. High LH levels are an independent marker of CV risk. Further studies are needed for clarifying determinants and mechanisms of testis enlargement that, beyond gonadotropins, could mediate the increased incidence of MACE.
Tomato yellow leaf curl Sardinia virus‐resistant tomato plants expressing the multifunctional N‐terminal domain of the replication‐associated protein show transcriptional changes resembling stress‐related responses
Authors: Lucioli Alessandra , Berardi Alessandra , Gatti Francesca , Tavazza Raffaela , Pizzichini Daniele , Tavazza Mario 
Published: July 2013

SummaryThe N‐terminal domain (amino acids 1–130) of the replication‐associated protein (Rep130) of Tomato yellow leaf curl Sardinia virus (TYLCSV) retains the ability of full‐length Rep to localize to the nucleus and to down‐regulate C1 transcription when ectopically expressed in plants, both functions being required to inhibit homologous viral replication. In this study, we analysed the effect of Rep130 expression on virus resistance and the plant transcriptome in the natural and agronomically important host species of TYLCSV, Solanum lycopersicum. Tomato plants accumulating high levels of Rep130 were generated and proved to be resistant to TYLCSV. Using an in vitro assay, we showed that plant‐expressed Rep130 also retains the catalytic activity of Rep, thus supporting the notion that this protein domain is fully functional. Interestingly, Rep130‐expressing tomatoes were characterized by an altered transcriptional profile resembling stress‐related responses. Notably, the serine‐type protease inhibitor (Ser‐PI) category was over‐represented among the 20 up‐regulated genes. The involvement of Rep130 in the alteration of host mRNA steady‐state levels was confirmed using a distinct set of virus‐resistant transgenic tomato plants expressing the same TYLCSV Rep130, but from a different, synthetic, gene. Eight genes were found to be up‐regulated in both types of transgenic tomato and two encoded Ser‐PIs. Four of these eight genes were also up‐regulated in TYLCSV‐infected wild‐type tomato plants. Implications with regard to the ability of this Rep domain to interfere with viral infections and to alter the host transcriptome are discussed.
Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis
Authors: Qin Jiao , Xie Yan‐yun , Huang Ling , Yuan Qiong‐jing , Mei Wen‐Juan , Yuan Xiang‐ning , Hu Gao‐yun , Cheng Guang‐jie , Tao Li‐jian , Peng Zhang‐zhe 
Published: July 2013

AbstractAimOxidative stress plays an important role in the progression of renal interstitial fibrosis. The nicotinamide adeninedinucleotide phosphate (NADPH) oxidase (Nox) family is considered one of the major sources of reactive oxygen species (ROS). In the present study, we investigated the inhibitory effects of a novel anti‐fibrotic agent, Fluorofenidone (AKF‐PD), upon Nox‐mediated oxidative stress and deposition of extracellular matrix (ECM) in the development of renalinterstitial fibrosis.MethodsAKF‐PD was used to treat renal fibrosis in unilateral ureteral obstruction (UUO) obstructive nephropathy in rats. The expression of Nox homologues, p‐Akt, collagen I and III were detected by immunoblotting or immunohistochemistry. Levels of 8‐iso prostaglandin F2alpha (8‐Iso PGF2a) was measured by enzyme linked immunosorbent assay. In addition, ROS and the expression of collagen I (1a), Nox subunits and p‐Akt was measured in angiotensin (Ang) II‐stimulated rat proximal tubular epithelial (NRK‐52E) cells in culture.ResultsAKF‐PD treatment significantly attenuated tubulo‐interstitial injury, ECM deposition and oxidative stress in fibrotic rat kidneys. In addition, AKF‐PD inhibited the expression of ROS, Collagen I (1a), Nox2, p‐Akt in Ang II‐stimulated NRK‐52E cells.ConclusionAKF‐PD attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signalling pathway, suggesting AKF‐PD is a potential novel therapeutic agent against renal fibrosis.
The role of adipocytes in the modulation of iron metabolism in obesity
Authors: Coimbra S. , Catarino C. , Santos‐Silva A. 
Published: July 2013

SummaryA tight relationship between iron deficiency and obesity is known to exist. The chronic low‐grade inflammation that characterizes obesity enhances hepcidin production, the principal regulator of iron availability. Adipose tissue is known to secret interleukin‐6 and leptin that triggers hepcidin production. It was found that adipose tissue also expresses hepcidin and hemojuvelin, a regulator of hepcidin production. These recent findings suggest that adipose tissue may have an important role in erythropoiesis particularly on obesity that is still poorly clarified. This paper discusses these findings and how they can modulate erythropoiesis.
Cloning, characterization and overexpression of a 14‐3‐3 ω protein from oil palm (Elaeis guineensis)
Authors: Nakkaew Alisa , Thitichai Natthaphatra , Nualkaew Sureeporn , Chotigeat Wilaiwan , Phongdara Amornrat 
Published: July 2013

AbstractPlant 14‐3‐3 proteins are involved in signal transduction pathways of nitrogen and carbohydrate metabolism. An Eg14‐3‐3 ω gene was isolated from the mesocarp of oil palm. The 1055‐bp cDNA had an open reading frame of 774 bp that encoded for 258 amino acids, and the cDNA had 113‐bp and 195‐bp 5′‐ and 3′‐untranslated regions, respectively. The calculated molecular weight was 28.06 kDa, with a pI of 5.04. The palm 14‐3‐3 showed closest identity to 14‐3‐3 proteins of the omega group. The entire sequence of Eg14‐3‐3 ω showed 83% identity with 14‐3‐3 protein isoform 16R from Solanum tuberosum. Phylogenetic analysis showed that the Eg14‐3‐3 isoform was within the omega (ω) subgroup and, thus, was designated Eg14‐3‐3 ω. The Eg14‐3‐3 ω expression patterns were strong in the mesocarp as compared to the root. When Eg14‐3‐3 ω cDNA was overexpressed in transgenic calli, there was higher accumulation of oil in the transgenic calli than in the controls. Therefore, Eg14‐3‐3 ω has potential for applications in the breeding of oil palms in the future.