bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single administration of lesion‐limited high‐dose (TURBO) ultraviolet B using the excimer laser: clinical clearing in association with apoptosis of epidermal and dermal T cell subsets in psoriasis
Authors: Kagen Mark , Cao Lauren Y. , Oyetakin‐White Patricia , Tacastacas Joselin D. , Yan Chunlin , McCormick Thomas S. , Cooper Kevin D. 
Published: November 2012

SummaryBackground/PurposeDevelopment of effective therapy for psoriasis is confounded by numerous factors contributing to disease pathogenesis, including pathogenic immunocytes which appear to drive epidermal keratinocyte hyperproliferation. Our objective was to study clinical and biomarker effects of a single dose of TURBO laser UVB (308 nm) applied directly to psoriatic plaques.MethodsEighteen patients with chronic plaque psoriasis received a single dose of 10 minimal erythema dose (MED) UVB and were followed for 8 weeks. Keratome and punch biopsies were assessed for T cell depletion and apoptosis following a single 308‐nm dose of UVB.ResultsPatients demonstrated clinical improvement as indicated by decreased global Psoriasis Area and Severity Index scores and reduced numbers of pathogenic memory/effector T cells infiltrating lesional epidermis and dermis. Consistent with apoptosis induction, caspase activation increased in lesional T cells after treatment.ConclusionWe conclude that a single 10 MED dose of TURBO UVB is effective at reducing the severity and extent of psoriatic lesions. We hypothesize that the reason a single treatment is sufficient to clear a psoriatic plaque is that the 10 MED dose is able to deliver sufficient photons to a microanatomic area of the lesion where susceptible pathogenic T cell mechanisms are operative.
Perception of xeroderma pigmentosum support group members of xeroderma pigmentosum lifestyle impact
Authors: Hawkins Danielle M. , Eide Melody J. , Lim Henry W. 
Published: November 2012

SummaryXeroderma pigmentosum (XP) is a genetic condition, which can cause an extreme sensitivity to sunlight and an increased risk of skin cancer due to errors in DNA repair. An online survey was administered to a convenience sample of participants who were members of an online support group for XP patients and their families to determine common symptoms and quality of life. The Dermatologic Life Quality Index (DLQI) or the Children's Dermatologic Life Quality Index (CDLQI) was used depending on patient age. A total of four patients and two parents of young patients completed our survey. Quality of life as measured through the DLQI and CDLQI was moderately affected.
Aquaporin‐2 regulation in health and disease
Authors: Judith Radin M. , Yu Ming‐Jiun , Stoedkilde Lene , Lance Miller R. , Hoffert Jason D. , Frokiaer Jorgen , Pisitkun Trairak , Knepper Mark A. 
Published: November 2012

AbstractAquaporin‐2 (AQP2), the vasopressin‐regulated water channel of the renal collecting duct, is dysregulated in numerous disorders of water balance in people and animals, including those associated with polyuria (urinary tract obstruction, hypokalemia, inflammation, and lithium toxicity) and with dilutional hyponatremia (syndrome of inappropriate antidiuresis, congestive heart failure, cirrhosis). Normal regulation ofAQP2by vasopressin involves 2 independent regulatory mechanisms: (1) short‐term regulation ofAQP2trafficking to and from the apical plasma membrane, and (2) long‐term regulation of the total abundance of theAQP2protein in the cells. Most disorders of water balance are the result of dysregulation of processes that regulate the total abundance ofAQP2in collecting duct cells. In general, the level ofAQP2in a collecting duct cell is determined by a balance between production via translation ofAQP2mRNAand removal via degradation or secretion into the urine in exosomes.AQP2abundance increases in response to vasopressin chiefly due to increased translation subsequent to increases inAQP2mRNA. Vasopressin‐mediated regulation ofAQP2gene transcription is poorly understood, although several transcription factor‐binding elements in the 5′ flanking region of theAQP2gene have been identified, and candidate transcription factors corresponding to these elements have been discovered in proteomics studies. Here, we review progress in this area and discuss elements of vasopressin signaling in the collecting duct that may impinge on regulation ofAQP2in health and in the context of examples of polyuric diseases.
Concomitant occurrence of hypohyperdontia in a patient with Marfan syndrome: a review of the literature and report of a case
Authors: Mallineni Sreekanth K. , Jayaraman Jayakumar , Yiu Cynthia K.Y. , King Nigel M. 
Published: November 2012

AbstractMarfan syndrome is an autosomal dominant genetic disorder of connective tissue origin that can affect multiple organs. Various oral manifestations have been associated with this syndrome. Hypohyperdontia is a condition of mixed numeric variations that presents a combination of hypodontia with hyperdontia within a single human dentition. The purpose of this paper is to report a case of Marfan syndrome with a concomitant occurrence of hypohyperdontia. A narrative review was also included to describe the other syndromes that had been associated with concomitant hypohyperdontia.
Factors affecting oral malodor in periodontitis and gingivitis patients
Authors: Pham Thuy A.V. , Ueno Masayuki , Shinada Kayoko , Kawaguchi Yoko 
Published: November 2012

AbstractAimTo examine the associations between oral health status, the presence of N‐benzoyl‐DL‐arginine‐2‐naphthylamide‐positive bacteria, and oral malodor in periodontal patients.MethodsA total of 137 periodontitis and 80 gingivitis patients were included in the study. Oral malodor was measured by an organoleptic test and the OralChroma. An oral examination was conducted, including the assessment of decayed teeth, periodontal status, and tongue coating. The presence of N‐benzoyl‐DL‐arginine‐2‐naphthylamide‐positive bacteria in the subgingiva, tongue coating, and saliva was evaluated by the N‐benzoyl‐DL‐arginine‐2‐naphthylamide test.ResultsIn the periodontitis group, oral malodor was significantly correlated with decayed teeth, periodontal parameters, and tongue coating. Among the N‐benzoyl‐DL‐arginine‐2‐naphthylamide test parameters, the highest correlation of oral malodor was found with N‐benzoyl‐DL‐arginine‐2‐naphthylamide subgingiva, followed by N‐benzoyl‐DL‐arginine‐2‐naphthylamide tongue coating and N‐benzoyl‐DL‐arginine‐2‐naphthylamide saliva. In the gingivitis group, oral malodor was significantly correlated with the plaque index, bleeding on probing, and tongue coating. Among the N‐benzoyl‐DL‐arginine‐2‐naphthylamide test parameters, the highest correlation of oral malodor was found with N‐benzoyl‐DL‐arginine‐2‐naphthylamide tongue coating, followed by N‐benzoyl‐DL‐arginine‐2‐naphthylamide saliva and N‐benzoyl‐DL‐arginine‐2‐naphthylamide subgingiva.ConclusionDental plaque, bleeding on probing, tongue coating, and N‐benzoyl‐DL‐arginine‐2‐naphthylamide‐positive bacteria contribute to oral malodor, but with different degrees in periodontitis and gingivitis patients.
Genetic variation in Norwegian piscine myocarditis virus in Atlantic salmon, Salmo salar L.
Authors: Wiik‐Nielsen J , Alarcón M , Fineid B , Rode M , Haugland Ø 
Published: November 2012

AbstractCardiomyopathy syndrome (CMS) in Atlantic salmon, Salmo salar L., is a severe cardiac disease characterized by a necrotizing myocarditis involving the atrium and the spongious part of the ventricle. The disease is caused by piscine myocarditis virus (PMCV), a double‐stranded RNA virus likely belonging to the family Totiviridae. The objective of this study was to evaluate the genetic variation in Norwegian PMCV isolates focusing on the putative structural proteins encoded by open reading frames (ORFs) 1 and 3. The virus isolates were sampled from a total of 36 farms along the Norwegian coastline. This study represents the first investigation of PMCV genome variation and shows that Norwegian isolates are highly similar, with the most divergent isolates sharing 98.6% nucleotide identity. Interestingly, amino acid sequence diversity within ORF3 is approximately threefold higher than for ORF1. While phylogenetic analysis based on concatenated nucleotide data covering ORF1 and ORF3 revealed four main clusters, the maximum sequence variation of 1.4% at the nucleotide level suggests that all Norwegian isolates belong to a single genogroup. Substantial sequence variation within farms was also observed, which may complicate future molecular epidemiological investigations. The genetic homogeneity among the Norwegian isolates might facilitate development of both diagnostic tools and an efficient vaccine against CMS in the future.
Viscous Flow Behavior, Microstructure and Physicochemical Characteristics of a Sweet Paste Functional Dessert (Samanu) Made from Germinated Wheat
Authors: Amiryousefi Mohammad Reza , Razavi Seyed M.A. 
Published: November 2012

AbstractSamanu is a functional dessert made traditionally from germinated wheat and whole wheat flours over minimum heating, and is rich in some important vitamins and minerals. In this study, the chemical compositions, color, microstructure and steady‐shear flow behavior of different Samanu samples were determined. The flow behavior was adequately described by the power law model and all samples behaved as shear‐thinning fluids. The flow behavior index ranged from 0.48 to 0.98, while the consistency index was between 0.006 and 11.46 Pa·sn. Furthermore, the Samanu samples revealed that the thixotropic behavior and the time dependency data fitted well with Weltman model. During the preparation of Samanu, development of brown color and significant reduction in lightness from 46.61 to 20.07 were observed. The morphological differentiations of the Samanu samples were closely related to their rheological properties.Practical ApplicationsIt is well known that there is still a significant search for new products with excellent functional properties and good price, which could be a potential alternative to some commercial foods. Understanding the physical and chemical properties of semisolid food products like Samanu (as a new functional dessert) is very important in view of industrial applications. Determinations of the rheological parameters, such as flow behavior, yield stress, apparent viscosity at a specific shear rate and thixotropy, are necessary for proper characterization of the product and scaling up of the production. In this study, color changes during Samanu preparation and also the morphology of the final products were evaluated to relate them with the rheological properties, and comparison to trademark and traditional samples was performed.
Mycoflora and Aflatoxin Analysis of Arachis hypogaeaL. and Assessment of Anethum graveolensL. Seed and Leaf Essential Oils against Isolated Fungi, Aflatoxin Production and their Antioxidant Activity
Authors: Prakash Bhanu , Singh Priyanka , Kedia Akash , Dwivedy Abhishek Kumar , Singh Anita , Dubey Nawal Kishore 
Published: November 2012

AbstractThe present investigation reports the extent of fungal contamination in stored samples of Arachis hypogaea and efficacy of seed and leaf essential oils (EOs) of Anethum graveolens against isolated fungi, aflatoxin production and their antioxidant efficacy. Twelve fungal species were found associated with A. hypogaea along with toxigenic isolates of Aspergillus flavus. The minimum concentrations for inhibition of growth of toxigenic strain of A. flavus (LHPFah‐6) and aflatoxin production were found to be 1.25 and 1.0 μL/mL for seed oil and 7.0 and 6.0 μL/mL for leaf oil. The EOs exhibited broad antifungal spectrum. The seed and leaf EOs also exhibited free radical‐scavenging activity having IC50 value 12.4 and 24.3 μL/mL, respectively. In addition, the EOs showed nonphytotoxic nature on radicle growth of A. hypogaea. The study recommends A. graveolens seed EO as a potent antifungal, aflatoxin inhibitor and free radical‐neutralizing agent to enhance shelf life of food items.Practical ApplicationsBecause of high efficacy as antifungal, aflatoxin inhibitor and antioxidant, as well as due to nonphytotoxic nature, the A. graveolens seed essential oil may attract the food industries related to food safety for its large‐scale trial to recommend its possible application as an eco‐friendly plant‐based alternative of synthetic preservatives during postharvest processing of food items.
An Efficient Rice Mutagenesis System Based on Suspension‐Cultured Cells
Authors: Chen Yuan‐Ling , Liang Hui‐Lin , Ma Xing‐Liang , Lou Su‐Lin , Xie Yong‐Yao , Liu Zhen‐Lan , Chen Le‐Tian , Liu Yao‐Guang 
Published: November 2012

AbstractPlant mutants are important bio‐resources for crop breeding and gene functional studies. Conventional methods for generating mutant libraries by mutagenesis of seeds with physical or chemical agents are of low efficiency. Here, we developed a highly‐efficient ethyl methanesulfonate (EMS) mutagenesis system based on suspension‐cultured cells, with rice (Oryza sativa L.) as an example. We show that treatment of suspension‐cultured tiny cell clusters with 0.4% EMS for 18–22 h followed by differentiation and regeneration produced as high as 29.4% independent mutant lines with visible phenotypic variations, including a number of important agronomic traits such as grain size, panicle size, grain or panicle shape, tiller number and angle, heading date, male sterility, and disease sensitivity. No mosaic mutant was observed in the mutant lines tested. In this mutant library, we obtained a mutant with an abnormally elongated uppermost internode. Sequencing and functional analysis revealed that this is a new allelic mutant of eui (elongated uppermost internode) caused by two point mutations in the first exon of the EUI gene, representing a successful example of this mutagenesis system.
Dynamic Actin Controls Polarity Induction de novo in Protoplasts
Authors: Zaban Beatrix , Maisch Jan , Nick Peter 
Published: November 2012

AbstractCell polarity and axes are central for plant morphogenesis. To study how polarity and axes are induced de novo, we investigated protoplasts of tobacco Nicotiana tabacum cv. BY‐2 expressing fluorescently‐tagged cytoskeletal markers. We standardized the system to such a degree that we were able to generate quantitative data on the temporal patterns of regeneration stages. The synthesis of a new cell wall marks the transition to the first stage of regeneration, and proceeds after a long preparatory phase within a few minutes. During this preparatory phase, the nucleus migrates actively, and cytoplasmic strands remodel vigorously. We probed this system for the effect of anti‐cytoskeletal compounds, inducible bundling of actin, RGD‐peptides, and temperature. Suppression of actin dynamics at an early stage leads to aberrant tripolar cells, whereas suppression of microtubule dynamics produces aberrant sausage‐like cells with asymmetric cell walls. We integrated these data into a model, where the microtubular cytoskeleton conveys positional information between the nucleus and the membrane controlling the release or activation of components required for cell wall synthesis. Cell wall formation is followed by the induction of a new cell pole requiring dynamic actin filaments, and the new cell axis is manifested as elongation growth perpendicular to the orientation of the aligned cortical microtubules.
Relationship between anti‐apoptotic proteins survivin and Bcl‐2, and response to treatment in patients undergoing post‐operative RT for laryngeal cancer: a pilot study
Authors: Marioni Gino , Staffieri Alberto , Lionello Marco , Tealdo Giulia , Staffieri Claudia , Giacomelli Luciano , Friso Maria Luisa , Stramare Roberto , Ottaviano Giancarlo , Blandamura Stella 
Published: November 2012

BackgroundClinicopathological research has focused on identifying molecular and biological prognostic factors for laryngeal carcinoma (LSCC) treated with post‐operative radiotherapy (RT). The aim of this study was to assess the prognostic importance of anti‐apoptotic proteins survivin and B‐cell lymphoma‐2 (Bcl‐2) in a series of patients with LSCC who had primary surgery followed by RT.MethodsThirty‐three consecutive patients who underwent primary surgery followed by RT were considered. Survivin nuclear and cytoplasmic expressions and Bcl‐2 expression were determined immunohistochemically.ResultsThe loco‐regional recurrence rate was significantly higher among LSCC patients with a nuclear survivin expression >10.0% (P = 0.029), and their disease‐free survival (DFS) was shorter than in cases whose nuclear survivin expression was ≤10.0% (P = 0.002). DFS was significantly shorter in cases with a Bcl‐2 expression >2.0% than in those whose Bcl‐2 expression was ≤2.0% (P = 0.035).ConclusionsNuclear survivin expression and Bcl‐2 expression warrant further investigation as potential predictive biomarkers to enable individualized treatments (e.g. post‐operative chemo‐radiotherapy instead of RT alone for patients whose LSCCs strongly express nuclear survivin or/and Bcl‐2). This preliminary evidence justifies the design of new studies on the association of agents targeting survivin and Bcl‐2 with conventional chemotherapeutic agents and RT for advanced LSCC.
What Do We Know When We Know a PersonAcross Contexts? Examining Self‐Concept Differentiation at the Three Levels of Personality
Authors: Dunlop William L. , Walker Lawrence J. , Wiens Thomas K. 
Published: November 2012

AbstractObjectivePrevious research examining self‐concept differentiation (SCD) has been characterized by (a) a focus on behavioral traits and (b) the conflation of mean‐level and inter‐contextual differentiation. In two studies, we considered non‐conflated measures ofSCDat the three levels of personality description in relation to adjustment.MethodIn Study 1, participants completed measures of adjustment, rated their behavioral tendencies (dispositional traits), produced a list of goals (characteristic adaptations), and recalled a self‐defining memory (life narratives), from within professional and personal domains. In Study 2, the procedure was modified: Participants reporting either low or high levels of adjustment subsequently rated their behavioral traits, provided a list of goals, or produced a self‐defining memory, from five contexts.ResultsIn Study 1, adjustment related positively toSCDat the level of characteristic adaptations but negatively toSCDat the level of life narratives. In Study 2, well‐adjusted participants exhibited a greater degree ofSCDat the level of characteristic adaptations but a greater degree of thematic consistency at the level of life narratives, relative to those low in adjustment.ConclusionsThese results highlight the dynamic nature ofSCDacross levels of personality and align with the notion that differentiation represents virtue and vice.
The Role of Personality in Predicting Repeat Participation in Periodic Health Screening
Authors: Armon Galit , Toker Sharon 
Published: November 2012

AbstractObjectiveDrawing on the Five‐Factor Model of personality, the aim of the present study was to find out which personality traits predict health maintenance behaviors, reflected in routine participation in health screenings, over and above objective and subjective health status.MethodParticipants were 2,803 employed individuals (61% men), free of background diseases, who underwent a routine health examination and were subsequently notified whether they were healthy or at risk. These participants were invited to repeat the examination within the next few years, as is medically recommended.ResultsLogistic and negative binomial regressions were used to predict participants' odds of returning for a second examination, within the next 7 years, as well as the number of consecutive visits, while controlling for sociodemographic factors, objective and subjective health, and length of follow‐up. We found that both endpoints were positively predicted by Conscientiousness and negatively predicted by Extraversion and Openness. The association between Neuroticism and these endpoints followed a bell‐shaped curve (i.e., individuals high or low in Neuroticism were less likely to return).ConclusionsThe present findings suggest that personality traits should be taken into consideration in the planning and implementation of health‐promoting interventions.
Multiple modes for gatekeeping at fungal cell‐to‐cell channels
Authors: Jedd Gregory , Pieuchot Laurent 
Published: November 2012

SummaryCell‐to‐cell channels appear to be indispensable for successful multicellular organization and arose independently in animals, plants and fungi. Most of the fungi obtain nutrients from the environment by growing in an exploratory and invasive manner, and this ability depends on multicellular filaments known as hyphae. These cells grow by tip extension and can be divided into compartments by cell walls that typically retain a central pore that allows intercellular transport and cooperation. In the major clade of filamentous Ascomycota, integrity of this coenocytic organization is maintained by Woronin body organelles, which function as emergency patches of septal pores. In this issue of Molecular Microbiology, Bleichrodt and co‐workers show that Woronin bodies can also form tight reversible associations with the pore and further link this to variation in levels of compartmental gene expression. These data define an additional modality of Woronin body‐dependent gatekeeping. This commentary focuses on the implications of this work and the potential role of different modes of pore gating in controlling the growth and development of fungal tissues.
A No‐Arbitrage Structural Vector Autoregressive Model of the UK Yield Curve*
Authors: Kaminska Iryna 
Published: November 2012

AbstractThis article combines a Structural Vector Autoregression with a no‐arbitrage approach to build a multifactor Affine Term Structure Model (ATSM). The resulting No‐Arbitrage Structural Vector Autoregressive (NASVAR) model implies that expected excess returns are driven by structural macroeconomic shocks. This is in contrast with a standard ATSM, in which agents are concerned with non‐structural risks. As a simple application, we study the effects of supply, demand and monetary policy shocks on the UK yield curve. We show that all structural shocks affect the slope of the yield curve, with demand and supply shocks accounting for a large part of the time variation in bond yields.
A Canonical Correlation Approach for Selecting the Number of Dynamic Factors
Authors: Breitung Jörg , Pigorsch Uta 
Published: November 2012

AbstractIn this article, we propose a selection procedure that allows us to consistently estimate the number of dynamic factors in a dynamic factor model. The procedure is based on a canonical correlation analysis of the static factors which has the advantage of being invariant to a rescaling of the factors. Monte Carlo simulations suggest that the proposed selection rule outperforms existing ones, in particular, if the contribution of the common factors to the overall variance is moderate or low. The new selection procedure is applied to the US macroeconomic data panel used in Stock and Watson [NBER working paper 11467 (2005)].