bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tinjauan Kepastian Hukum Terhadap Hasil Kesepakatan Perdamaian dalam Mediasi di Luar Pengadilan
Authors: Fitriani Rini , Asnawi M. Iqbal , Muis Arman , Fatimah  , Mirfa Enny 
Published: July 2024

Sengketa merupakan bentuk aktualisasi atas perbedaan kepentingan diantara kedua belah pihak atau lebih. Munculnya sengketa apabila pihak yang merasa dirugikan menuntut haknya untuk menyelesaikan masalahnya dengan pihak yang menimbulkan kerugian. Penyelesaian sengketa para pihak mencari jalan penyelesaian yang mudah, cepat dan adil, dimana kedua belah pihak tidak merasa dirugikan (win-win solution) yaitu melalui alternatif penyelesaian di luar Pengadilan. Salah satu bentuk penyelesaian sengketa di luar pengadilan adalah Mediasi. Mediasi merupakan penyelesaian sengketa melalui perundingan dengan bantuan pihak ketiga netral (mediator) guna mencari bentuk penyelesaian yang dapat disepakati para pihak. Mediasi pada dasarnya adalah musyawarah dan mufakat. Jika secara mediasi terdapat kata sepakat, maka akan dituangkan dalam suatu kesepakatan perdamaian. Namun ketika salah satu pihak tidak melaksanakan kesepakatan perdamaian dengan itikad tidak baik maka akibatnya membuat pihak yang dirugikan tidak mendapatkan kepastian hukum karena tidak dapat mengajukan permohonan eksekusi ke Pengadilan atau tidak memiliki kekuatan eksekutorial. Timbul permasalahan 1) upaya yang dapat ditempuh bagi para pihak dalam menyelesaikan sengketa perdata melalui proses mediasi dan 2) proses mediasi yang memberikan jaminan kepastian hukum dalam mengeksekusi hasil kesepakatan para pihak. Penelitian ini adlah penelitian normatif bersifat kualitatif dan perspektif, pada penelitian hukum normatif akan menginterpretasi secara preskriptif tentang hukum sebagai suatu system nilai ideal, hukum sebagai sistem konseptual, dan hukum sebagai sistem hukum positif. Hasil penelitian 1) Upaya penyelesaian sengketa melalui mediasi dilakukan melalui tahan-tahap yang dilaksanakan dengan bantuan mediator yang netral sampai menghasilkan kesepakatan perdamaian. 2) Untuk memperoleh kepastian hukum para pihak harus sepakat untuk mengukuhkannya menjadi akta perdamaian, sehingga kesepakatan perdamaian tersebut memiliki kekuatan hukum.
PENGARUH KUALITAS PRODUK, HARGA DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN SMARTPHONE PADA METEORCELL MALANG
Authors: Maky Zainuddin Ahmad , Pradiani Theresia , Rahman Agus 
Published: July 2024

Penelitian ini bermaksud untuk menganalisis pengaruh kualitas produk, harga dan promosi terhadap keputusan pembelian smartphone pada Meteorcell Malang. Penelitian ini menggunakan teknik random sampling dengan menyebarkan kuesioner secara langsung kepada para pelanggan Meteorcell Malang. Data penelitian diolah secara kuantitatif deskriptif dengan teknik analisis jalur, menggunakan Aplikasi SPSS versi 22.0. Hasil penelitian didukung data primer yang diperoleh dari hasil pengisian kuesioner. Hasil penelitian menunjukkan bahwa (1) kualitas produk berpengaruh terhadap keputusan pembelian (2) harga tidak berpengaruh signifikan terhadap keputusan pembelian (3) promosi tidak berpengaruh signifikan terhadap keputusan pembelian.
تأثير تمرينات بمصاحبة المنظومة الذكية في بعض القدرات التوافقية لحراس مرمى كرة اليد بأعمار 13-15 سنة
Authors: Asst. Lec. Hussein Mahdi Saleh  , Prof. Dr. Hassim Abdul Jabbar Saleh  
Published: July 2024

تم تحديد مشكلة البحث من خلال خبرة الباحثان العلمية في مجال تدريب كرة اليد وبعد الاطلاع على حراس المرمى لدى منتخب تربية كربلاء ولاسيما عينة الدراسة الذين بأعمار 13-15 سنه فقد لأحظو إن هناك ضعف في القدرات التوافقية ولا سيما ( التوازن والاستجابة السريعة والتكيف مع الأوضاع المتغيرة) لديهم من خلال الوصول البطيء الى الكرة بالوقت المحدد وكذلك هناك ضعف في الجانب المهاري لحراس المرمى نتيجة الاهتمام الغير كافي في هذه الفئة بالإضافة الى اعتماد المدربين على التمارين التقليدية والابتعاد عن استخدام أجهزة والتقنيات الحديثة في التدريب مما يؤثر سلبا على الاداء المهاري ، حيث ان حارس المرمى يحتاج الى جهد مضاعف عن باقي اللاعبين وما يحتاجه من قدرات توافقية ومهارات أساسية خاصة يتمتع بها صاحب هذا المركز حتى يتم وصولة الى مستوى عالي وهذا الجهد يحتاج الى فترة طويلة للحصول على هذه النتائج وان استخدام التكنلوجيا والأجهزة الحديثة لها دور أساسي ومهم في العملية التدريبية وبالأخص الفئات العمرية وهذا ما يسعى اليه الباحثان إلى خوض غمار هذه التجربة باستخدام أجهزة ذكية ليساهم في تطوير امكانيات حراس المرمى والارتقاء بمستوى الاداء. وهدف الباحثان اعداد تمرينات بمصاحبة المنظمة الذكية لحراس مرمى كرة اليد بأعمار (13-15) سنة، استخدم الباحثان المنهج التجريبي بتصميم المجموعة الواحدة، وتم تحديد مجتمع البحث بلاعبي منتخب تربية كربلاء بأعمار 13-15 سنة والبالغ عددهم (6) حراس مرمى، تم اختيارهم جميعا كعينة للبحث وبأسلوب الحصر الشامل، وقد استنتج الباحثان ان تمرينات المنظومة الذكية قد أسهمت في تطور القدرات التوافقية لحراس المرمى بكرة اليد اذ حققت تأثيراً ايجابيا وفعالا في اغراضها التي وضعت من اجلها.
Perspectivas inclusivas presentes em práticas pedagógicas voltadas para a produção de histórias infantis
Authors: Rosa Farto Lopes Valéria , Pinheiro de Oliveira Jáima 
Published: July 2024

O objetivo principal deste estudo foi analisar perspectivas inclusivas presentes em estratégias pedagógicas utilizadas com turmas de Educação Infantil e anos inicias do Ensino Fundamental, em atividades de produção de histórias infantis. De maneira secundária, propusemos um modelo de protocolo de observação para essas situações, que considera questões de acessibilidade. Participaram da pesquisa seis turmas de quatro escolas, contemplando 105 crianças e seis professoras. A geração de dados ocorreu numa cidade de pequeno porte, no interior do Estado de São Paulo, por meio de observações organizadas em seis sessões, sendo uma para cada turma. Os registros foram efetuados em dias de atividades que envolviam a produção de histórias infantis. Estes registros abordaram aspectos relacionados ao tipo de história contemplada na atividade; às estratégias pedagógicas; aos recursos utilizados; ao engajamento e participação de todas as crianças da turma na atividade, dentre outros aspectos. Para este artigo, foram considerados os dados relacionados a uma categoria denominada Estratégias de Ensino, com quatro subcategorias: a) Organização das turmas e do ambiente; b) Acessibilidade; c) Línguas, sistemas, meios de comunicação e expressão utilizados; e d) Mediação docente e participação das crianças. Os resultados indicaram uma carência de mediações com uma maior variedade de recursos e estratégias de ensino, em que as histórias sejam apresentadas de uma forma que permita a participação de todas as crianças.
Editorial
Authors: Tavares Ujiie Nájela 
Published: July 2024

Neste primeiro volume e número, contamos com a contribuição de dezoito pesquisadores, autores e coautores, dos dez artigos apresentados, sendo um artigo de autoria internacional e nove nacionais, cujas contribuições significativas desde já agradecemos.
Os artigos aqui apresentados referendam o nosso compromisso enquanto grupo de pesquisadores(as) e estudiosos(as) com a educação, com o ensino, com a formação de professores e educadores em suas multíplas dimensões. Temos discussões temáticas importantes que abarcam a transformação docente como política pública educacional no Equador, no Paraguai e no Uruguai; a matemática, sua história e ensino aprendizagem alinhada aos desafios das tecnologias na formação de professores; a formação do pedagogo que atua em espaços da Educação Social; formação de professores para a Educação de Jovens e Adultos (EJA); a evasão escolar no Ensino Médio Noturno; perspectivas inclusivas presentes em práticas pedagógicas dos anos iniciais do Ensino Fundamental; biografia das idéias de Winnicott e o jogo como criação da vida; o brincar na natureza e as possibilidades para a Educação Infantil; a docência na Educação Infantil na perspectiva da Teoria Histórico-Cultural; e, a importância da brincadeira na mediação docente na primeira infância.
Nesta seara, as discussões propostas refletem temáticas significativas e dialógicas, as quais merecem chegar a comunidade de leitores da Revista FormAção, uma revista científica de caráter educativo e formativo interdisciplinar.
Supercooled preservation of cultured primary rat hepatocyte monolayers
Authors: Gokaltun Aslihan , Asik Eda , Byrne Delaney , Yarmush Martin L. , Usta O. Berk 
Published: July 2024

Supercooled preservation (SCP) is a technology that involves cooling a substance below its freezing point without initiating ice crystal formation. It is a promising alternative to prolong the preservation time of cells, tissues, engineered tissue products, and organs compared to the current practices of hypothermic storage. Two-dimensional (2D) engineered tissues are extensively used in in vitro research for drug screening and development and investigation of disease progression. Despite their widespread application, there is a lack of research on the SCP of 2D-engineered tissues. In this study, we presented the effects of SCP at −2 and −6°C on primary rat hepatocyte (PRH) monolayers for the first time and compared cell viability and functionality with cold storage (CS, + 4°C). We preserved PRH monolayers in two different commercially available solutions: Hypothermosol-FRS (HTS-FRS) and the University of Wisconsin (UW) with and without supplements (i.e., polyethylene glycol (PEG) and 3-O-Methyl-Α-D-Glucopyranose (3-OMG)). Our findings revealed that UW with and without supplements were inadequate for the short-term preservation of PRH monolayers for both SCP and CS with high viability, functionality, and monolayer integrity. The combination of supplements (PEG and 3-OMG) in the HTS-FRS solution outperformed the other groups and yielded the highest viability and functional capacity. Notably, PRH monolayers exhibited superior viability and functionality when stored at −2°C through SCP for up to 3 days compared to CS. Overall, our results demonstrated that SCP is a feasible approach to improving the short-term preservation of PRH monolayers and enables readily available 2D-engineered tissues to advance in vitro research. Furthermore, our findings provide insights into preservation outcomes across various biological levels, from cells to tissues and organs, contributing to the advancement of bioengineering and biotechnology.
Precise hourly personalized embryo transfer significantly improves clinical outcomes in patients with repeated implantation failure
Authors: Xu Yameng , Du Jing , Zou Yangyun , Lin Xiaoli , Chen Yulin , Ma Lan , Jiang Shan , Lin Xiufeng 
Published: July 2024

PurposeThis study investigated whether RNA-Seq-based endometrial receptivity test (rsERT)—which provides precision for the optimal hour of the window of implantation (WOI)—can improve clinical outcomes of frozen embryo transfer (FET) cycles in patients with a history of repeated implantation failure (RIF).MethodsPatients with a history of RIF who received at least one autologous high-quality blastocyst during the subsequent FET cycle were retrospectively enrolled and divided into two groups: rsERT and FET, comprising patients who underwent rsERT-guided pET (n=115) and standard FET without rsERT (n=272), respectively.ResultsIn the rsERT group, 39.1% (45/115) of patients were receptive. rsERT patients showed a higher probability of achieving both positive human chorionic gonadotropin (63.5% vs. 51.5%, P=0.03) and clinical pregnancy (54.8% vs. 38.6%, P=0.003) rates. In subgroup analysis, rsERT patients with non-receptive results had higher clinical pregnancy rates than patients undergoing FET (58.6% vs. 38.6%, P=0.003). rsERT patients with receptive results guided by rsERT with a precise WOI time had higher, although non-significant, clinical pregnancy rates (48.9% vs. 38.6%, P=0.192) than patients who underwent standard-time FET.ConclusionHourly precise rsERT can significantly improve the probability of achieving clinical pregnancy in patients with RIF, especially in those with non-receptive rsERT results.
A modified two-stage isolated bidirectional buck-DAB converter with a full-load ZVS range
Authors: Li Jinliang , Wan Dai , Lu Zhengmei , Xu Guo 
Published: July 2024

A modified two-stage buck-DAB (MBDAB) converter is proposed to improve the performance of the traditional two-stage buck-DAB (TSBDAB) converter. In the MBDAB converter, the DAB can work with fixed voltage gain and voltage-matched condition under a wide input voltage range. The voltage gain of the converter is adjusted through the added front-end stage, which is similar to a buck converter. Compared with the TSBDAB converter, only part of the transmitted power flows through the front-end stage, so the loss of the buck stage and the burden of zero-voltage switching (ZVS) can be reduced. Detailed analysis of the working principle, partial power characteristics, and the full-load ZVS range design are presented. To verify the effectiveness of the proposed MBDAB converter, experimental results are obtained from a prototype with a rated power of 1 kW.
Knowledge towards the health impacts of climate change and associated factors among undergraduate health sciences students in Amhara region: a multi-centered study
Authors: Alemayehu Meron Asmamaw , Workie Sewnet Getaye , Belew Makida Abate , Agimas Muluken Chanie , Derseh Nebiyu Mekonnen , Abuhay Habtamu Wagnew , Berihanu Redeat , Kinfe Fasika Terefe , Abebe Haymanot Assefa , zemene Sophiya , Bazezew Astewil Moges 
Published: July 2024

BackgroundIncreased knowledge about the health impacts of climate change would motivate health students and health professionals to adopt sustainable healthcare practices, design climate-centered health programs, help build climate-resilient health systems, and ultimately contribute to the global effort of mitigating climate change.MethodAn Institution-based cross-sectional study was conducted among Universities in the Amhara region. A total of 616 undergraduate health science students were included from three Universities. A validated, self-administered structured questionnaire was used. Data were analyzed using STATA™ version 14.0. A Logistic regression model was used to identify the factors associated with the health impacts of climate change. A P-value less than 0.05 was considered to be statistically significant.ResultOnly 48.5% (95% CI: 44.6, 52.4) of students had good knowledge regarding the health impacts of climate change. Sex of the student—male (AOR = 1.44, 95% CI: 1.032, 2.023), University (AOR = 0.534, 95% CI: 0.360, 0.792), and Department—comprehensive Nursing, (AOR = 0.264, 95% CI: 0.117, 0.592), Midwifery (AOR = 0.201, 95% CI: 0.085, 0.476), and Medical Laboratory (AOR = 0.151, 95% CI: 0.055, 0.413) were significantly associated factors.ConclusionThe knowledge of the health impacts of climate change among health science students was low. Sex, University, and Department were the associated factors. Hence, undergraduate health science programs should incorporate at least the fundamental details of climate change. Universities should also develop and use a harmonized curriculum.
Risks and coping strategies in the floodplain economic belt amid drought–flood challenges and climate change
Authors: Dong He , An Xianjuan , Zeng Xueting , Li Tienan , Teng Yun , Zhang Xinyu , Li Shupan 
Published: July 2024

In this study, a coupla risk combinations and coping strategies have been developed for confronting conflicts between population–economy development and water resource management (PEWM) due to population–industry transformation (PIT) into a floodplain of the economic belt under climate change. A location-entropy-based PVAR (Panel Vector Autoregression) model coupla-risk analysis (LPCR) can be introduced into PEWM to reflect the adverse effects of population–industry transformation on a special function area (e.g., floodplain) of the economic belt, where the coupla risk map has been addressed. Meanwhile, an adaptive scenario analysis-based stochastic–fuzzy method (ASSF) can be joined to deal with multiple uncertainties and their interactions due to subjective and artificial factors. The proposed LPCR and ASSF can be integrated into a risk-based stochastic–fuzzy scenario method framework (RASF) to apply for a practical PEWM case study of the Yongding River floodplain in the context of the coordinative development of the Beijing–Tianjin–Hebei economic belt, China. The results can be presented as follows: 1) the PIT was accelerated into the floodplain due to the fact that it can require more water resources, where each additional unit can promote the regional gross domestic product (GDP) by 0.019 units, increasing the water demand by 0.046 units. It can strengthen various risks such as water shortage, soil loss, and flood control investment in a floodplain of the economic belt; 2) the farmland returning to wetland (CFW) can decrease the water demand and shortage ratio (would be 0% at highest) for irrigation in the long run, but this would reduce the direct economic income of irrigation in the short run; 3) backward irrigative schemes and low water utilization efficiency require a cleaner production mode, which could reduce water shortages by 77.23 × 10^3 m3 at the highest; and 4) the combined policy (S12) can reduce coupla risks (including the risk of water shortage, soil loss, and flood) compared to other individual policies (S2, S4, S6, and S8). The findings can assist local decision-makers to gain insights into adjusting interegional strategies not only for remitting population–resource stress in core cities but also for improving the resilience against drought and flood in a floodplain area, which is conducive of the special function of the floodplain to support an integrated sustainable development of the economic belt.
Screening and the analysis of genotypic and phenotypic characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Fujian province, China
Authors: Zhou Jinfu , Zeng Yinglin , Tang Jianping , Chen Shihong , Li Guilin , Qiu Xiaolong , Zhao Peiran , Huang Ting , Luo Jinying , Lin Na , Xu Liangpu 
Published: July 2024

IntroductionGlucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked hereditary disorder in southern China. However, the incidence rate of G6PD deficiency and the frequency of the most common G6PD gene variants vary widely. The purpose of this study was to investigate the prevalence, genotype, and phenotypic features of G6PD deficiency in neonates in Fujian province, southeastern China.MethodsThis retrospective cohort study enrolled 2,789,002 newborns (1,521,431 males and 1,267,571 females) based on the newborn screening program for G6PD deficiency in Fujian Province between January 2010 and December 2021.ResultsOf the 2,789,002 newborns enrolled, 26,437 cases were diagnosed (22,939 males and 3,498 females), and the estimated prevalence of G6PD deficiency in Fujian province was 0.95%. The prevalence was significantly higher among males (1.51%) than in females (0.28%) (p &lt; 0.00001). Among the 3,198 patients with G6PD deficiency, 3,092 cases (2,145 males and 947 females) were detected to have G6PD gene variants. The top six prevalent genotypes identified represented 90.84% (2095/3,198) of the total and included c.1376G &gt; T (44.93%), c.1388G &gt; A (18.42%), c.1024C &gt; T (9.32%), c.95A &gt; G (8.69%), c.392G &gt; T (5.25%), and c.871G &gt; A (4.22%). The frequency of genotypes with c.1388G &gt; A, c.1024C &gt; T, and c.871G &gt; A was higher in males in the Fujian province than in females, while the frequency of genotypes with c.1376G &gt; T was lower. Furthermore, when comparing the enzyme activities of the top six prevalent genotypes, there were significant differences in the enzyme activities among the genotypes of male hemizygotes and female heterozygotes. According to the new classification of G6PD variants proposed by the World Health Organization (WHO), the variants with c.1376G &gt; T, c.95A &gt; G, and c.871G &gt; A were recognized as Class A, while the c.392G &gt; T, c.1388G &gt; A, and c.1024C &gt; T were recognized as Class B.DiscussionTo the best of our knowledge, this study is the first to systematically describe the overview of epidemiological characteristics of newborn G6PD deficiency in Fujian province, China, including the screening rate, incidence rate, and variant spectrum. Additionally, we elucidated the relationship between the distribution of enzyme activity with specific mutations and their WHO classification patterns. Our results could provide strategies for screening, diagnosis, and genetic counseling of G6PD deficiency in this area.
Comparison of “framework Shuffling” and “CDR Grafting” in humanization of a PD-1 murine antibody
Authors: Wang Yongmei , Chen Yi-Li , Xu Hui , Rana Gul E. , Tan Xiaorong , He Mengying , Jing Qingqing , Wang Qi , Wang Guifeng , Xie Zuoquan , Wang Chunhe 
Published: July 2024

IntroductionHumanization is typically adopted to reduce the immunogenicity of murine antibodies generated by hybridoma technology when used in humans.MethodsTwo different strategies of antibody humanization are popularly employed, including “complementarity determining region (CDR) grafting” and “framework (FR) shuffling” to humanize a murine antibody against human programmed death-1 (PD-1), XM PD1. In CDR-grafting humanization, the CDRs of XM PD-1, were grafted into the human FR regions with high homology to the murine FR counterparts, and back mutations of key residues were performed to retain the antigen-binding affinities. While in FR-shuffling humanization, a combinatorial library of the six murine CDRs in-frame of XM PD-1 was constructed to a pool of human germline FRs for high-throughput screening for the most favorable variants. We evaluated many aspects which were important during antibody development of the molecules obtained by the two methods, including antibody purity, thermal stability, binding efficacy, predicted humanness, and immunogenicity, along with T cell epitope prediction for the humanized antibodies.ResultsWhile the ideal molecule was not achieved through CDR grafting in this particular instance, FR-shuffling proved successful in identifying a suitable candidate. The study highlights FR-shuffling as an effective complementary approach that potentially increases the success rate of antibody humanization. It is particularly noted for its accessibility to those with a biological rather than a computational background. DiscussionThe insights from this comparison are intended to assist other researchers in selecting appropriate humanization strategies for drug development, contributing to broader application and understanding in the field.