bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Adverse Events After Implantation of Sirolimus-Eluting Stent and Bare-Metal Stent
Authors: Natsuaki Masahiro , Morimoto Takeshi , Furukawa Yutaka , Nakagawa Yoshihisa , Kadota Kazushige , Yamaji Kyohei , Ando Kenji , Shizuta Satoshi , Shiomi Hiroki , Tada Tomohisa , Tazaki Junichi , Kato Yoshihiro , Hayano Mamoru , Abe Mitsuru , Tamura Takashi , Shirotani Manabu , Miki Shinji , Matsuda Mitsuo , Takahashi Mamoru , Ishii Katsuhisa , Tanaka Masaru , Aoyama Takeshi , Doi Osamu , Hattori Ryuichi , Kato Masayuki , Suwa Satoru , Takizawa Akinori , Takatsu Yoshiki , Shinoda Eiji , Eizawa Hiroshi , Takeda Teruki , Lee Jong-Dae , Inoko Moriaki , Ogawa Hisao , Hamasaki Shuichi , Horie Minoru , Nohara Ryuji , Kambara Hirofumi , Fujiwara Hisayoshi , Mitsudo Kazuaki , Nobuyoshi Masakiyo , Kita Toru , Kimura Takeshi 
Published: February 2014

Background—
Late adverse events such as very late stent thrombosis (VLST) or late target-lesion revascularization (TLR) after first-generation sirolimus-eluting stents (SES) implantation have not been yet fully characterized at long term in comparison with those after bare-metal stent (BMS) implantation.

Methods and Results—

Among 13 058 consecutive patients undergoing first percutaneous coronary intervention in the Coronary REvascularization Demonstrating Outcome study-Kyoto registry Cohort-2, 5078 patients were treated with SES only, and 5392 patients were treated with BMS only. During 7-year follow-up, VLST and late TLR beyond 1 year after SES implantation occurred constantly and without attenuation at 0.24% per year and at 2.0% per year, respectively. Cumulative 7-year incidence of VLST was significantly higher in the SES group than that in the BMS group (1.43% versus 0.68%,
P
<0.0001). However, there was no excess of all-cause death beyond 1 year in the SES group as compared with that in the BMS group (20.8% versus 19.6%,
P
=0.91). Cumulative incidences of late TLR (both overall and clinically driven) were also significantly higher in the SES group than in the BMS group (12.0% versus 4.1%,
P
<0.0001 and 8.5% versus 2.6%,
P
<0.0001, respectively), leading to late catch-up of the SES group to the BMS group regarding TLR through the entire 7-year follow-up (18.8% versus 25.2%, and 10.6% versus 10.2%, respectively). Clinical presentation as acute coronary syndrome was more common at the time of late SES TLR compared with early SES TLR (21.2% and 10.0%).

Conclusions—
Late catch-up phenomenon regarding stent thrombosis and TLR was significantly more pronounced with SES than that with BMS. This limitation should remain the target for improvements of DES technology.
Calendars Beyond Borders: Exchange of Calendrical Knowledge Between Jews and Christians in Medieval Europe (12th-15th Century)
Authors: Nothaft C. Philipp E. , Isserles Justine 
Published: February 2014

Abstract
During the Middle Ages, calendars played a significant role in both the Jewish and Christian communities as a means of reckoning time and structuring religious worship. Although calendars spawned a rich and extensive literature in both medieval Latin and Hebrew, it remains a little-known fact that Jews and Christians studied not only their own calendrical traditions, but also those of their respective rival group: Jewish scribes incorporated Christian material into Hebrew calendrical manuscripts, while some Christian scholars even dedicated entire treatises to the calendar used by Jews. The present article will examine these sources from a comparative perspective and use them to shed new light on the intellectual exchange that took place between Jews and Christians during the twelfth to fifteenth centuries. Particular attention will be paid to the role of oral vs. written transmission in the transfer of calendrical knowledge from one context to another.
Implementation of the Cross-border Care Directive in EU Member States: Luxembourg
Authors: Schwebag Mike 
Published: February 2014

Abstract
The Cross-border Care Directive sets up basic patient rights in case of cross-border healthcare. These rights concern both the country of affiliation and the country of treatment of the patient. The article briefly describes the state of the transposition in Luxembourg, with a focus on the draft act on patients’ rights and obligations. This new act on patient rights and obligations will apply without distinction to domestic and cross-border patients, thus transposing most of Luxembourg’s obligations as a country of treatment of a cross-border patient.
Angle-Based Drawing Accuracy Analysis and Mental Models of Three-Dimensional Space
Authors: Carson Linda , Quehl Nadine , Aliev Inara , Danckert James 
Published: February 2014

Drawing from a still-life is a complex visuomotor task. Nevertheless, experts depict three-dimensional subjects convincingly with two-dimensional images. Studies of drawing have historically relied on human critics’ judgement of the drawings, the professional reputations and self-reported experience of the drawers. To extend that work, we developed an objective measurement of the accuracy of a perspective drawing, based on a comparison of the drawing with a ground truth photograph of the subject taken from the same viewpoint. If we measure the angles at intersecting edges in the drawings we can calculate both local errors and each person’s mean percentage magnitude error across angles in the still life. This gives a continuous objective measure of drawing accuracy that correlates well with years of art experience. Drawing expertise may depend to some extent on more accurate internal models of 3D space. To explore this possibility we had adults with a range of drawing experience draw a still life. Participants also made perceptual judgements of still lifes, both from direct observation and from an imagined side view. A conventional mental rotation task failed to differentiate drawing expertise. However, those who drew angles more accurately were also significantly better judges of slant, i.e., the pitch of edges in the still life. Those with the most drawing experience were significantly better judges of spatial extent, i.e., which landmarks were leftmost, rightmost, nearest, farthest etc. The ability to visualize in three dimensions the orientation and relationships of components of a still life predicts drawing accuracy and expertise.
Object Domains and the Experience of Beauty
Authors: Marković Slobodan 
Published: February 2014

The purpose of the present study was to specify whether the structure of the experience of beauty is domain-specific or domain-general. Five basic descriptors of the experience of beauty were specified: two central descriptors, Beauty and Attractiveness, and three descriptors that represented different 16 aspects of Beauty: Pleasure (hedonic aspect), Harmony (perceptual aspect), and Interestingness (motivational aspect). Four groups of 25 participants rated different sets of visual stimuli on the five bipolar seven-step scales: Beautiful–Ugly, Attractive–Repulsive, Pleasant–Unpleasant, Harmonious–Disharmonious and Interesting–Boring. In preliminary studies four sets of stimuli were extracted: (1) environmental scenes, (2) human faces and bodies, (3) abstract forms and (4) artworks. Correlations between descriptors, and multiple regression analyses revealed that, in all of the categories of objects, attractiveness was consistently closer to pleasure than harmony and interestingness. The relationships between the other descriptors were category-specific: beauty was closer to pleasure in cases of environmental objects and artworks and it was closer to harmony in the case of human faces and bodies and abstract forms. These results suggest that the structure of the experience of beauty is partially general to all categories of objects and partially domain-specific.
Spirituality in bedlam: Exploring professional conversations on acute psychiatric units
Authors: Suto Melinda J. , Smith Sharon 
Published: February 2014

Background. The inclusion of spiritual conversations in occupational therapy is congruent with the Canadian Model of Occupational Performance and Engagement, which identifies spirituality as the core of every human being. Research indicates that spirituality can be a resource for mental health recovery. Purpose. This manuscript reports on Part 2 of a research study that explored the experience of spiritual conversations for patients (Part 1) and mental health professionals (Part 2) on acute psychiatric units. Method. Eight acute-based mental health professionals (MHPs)/participants, representing a variety of disciplines, participated in a focus group or individual interview. Community-based participatory research, appreciative inquiry, and interpretive description provided methodological and analytic guidance. Findings. MHP/participants described challenges in setting boundaries related to spirituality conversations and discerning spiritual experience from psychosis. MHPs/participants emphasized the importance in providing an empathetic presence while also engaging in spiritual networking. Implications. Therapists can incorporate spiritual conversations with patients in acute psychiatric settings by taking specific actions to enhance their openness and engaging in spiritual networking.
Optimizing participation of children with autism spectrum disorder experiencing sensory challenges: A clinical reasoning framework
Authors: Ashburner Jill K. , Rodger Sylvia A. , Ziviani Jenny M. , Hinder Elizabeth A. 
Published: February 2014

Background. Remedial sensory interventions currently lack supportive evidence and can be challenging to implement for families and clinicians. It may be timely to shift the focus to optimizing participation of children with autism spectrum disorders (ASD) through accommodation and self-regulation of their sensory differences. Purpose. A framework to guide practitioners in selecting strategies is proposed based on clinical reasoning considerations, including (a) research evidence, (b) client- and family-centredness, (c) practice contexts, (d) occupation-centredness, and (e) risks. Key issues. Information-sharing with families and coaching constitute the basis for intervention. Specific strategies are identified where sensory aversions or seeking behaviours, challenges with modulation of arousal, or sensory-related behaviours interfere with participation. Self-regulatory strategies are advocated. The application of universal design principles to shared environments is also recommended. Implications. The implications of this framework for future research, education, and practice are discussed. The clinical utility of the framework now needs to be tested.
Belonging, occupation, and human well-being: An exploration
Authors: Hammell Karen R. Whalley 
Published: February 2014

Background. Researchers identify the importance of belonging to human well-being and provide evidence-based support for occupation as a medium for expressing and achieving a sense of belonging and connectedness. Purpose. The purpose of this article is to highlight the imperative for occupational therapy theory and practice to address occupations concerned with belonging needs. Key issues. Dominant occupational therapy models emphasise doing self-care, productive, and leisure occupations, thereby ignoring occupations undertaken to contribute to the well-being of others, occupations that foster connections to nature and ancestors, collaborative occupations, and those valued for their social context and potential to strengthen social roles. Implications. Belonging, connectedness, and interdependence are positively correlated with human well-being, are prioritized by the majority of the world’s people, and inform the meanings attributed to and derived from the occupations of culturally diverse people. If occupational therapy is to address meaningful occupations, attention should be paid to occupations concerned with belonging, connecting, and contributing to others.
The emerging role of occupational therapy in primary care
Authors: Donnelly Catherine A. , Brenchley Christie L. , Crawford Candace N. , Letts Lori J. 
Published: February 2014

Background. Few studies have examined the role of occupational therapy working in a primary care setting. Purpose. The objective of the study was to describe the emerging role of occupational therapy in Family Health Teams, a model of interprofessional primary care. Method. A multiple case study design was used to provide in-depth description of the occupational therapy role. Data collection included interviews, document analyses, and questionnaires. Each case was first analyzed individually, followed by cross-case analyses to determine common themes. Findings. The role of occupational therapy in Family Health Teams epitomizes that of a generalist, whose overarching focus is on function. Occupational therapists are working across the life span with a wide range of client populations. Older adults and individuals with complex chronic conditions are two prominent areas of occupational therapy focus. Implications. Understanding the impact of health conditions on daily function and enabling participation in activities are unique and important contributions of occupational therapy.
Control Order and Visuomotor Strategy Development for Joystick-Steered Underground Shuttle Cars
Authors: Cloete Steven , Zupanc Christine , Burgess-Limerick Robin , Wallis Guy 
Published: February 2014

Objective: In this simulator-based study, we aimed to quantify performance differences between joystick steering systems using first-order and second-order control, which are used in underground coal mining shuttle cars. In addition, we conducted an exploratory analysis of how users of the more difficult, second-order system changed their behavior over time. Background: Evidence from the visuomotor control literature suggests that higher-order control devices are not intuitive, which could pose a significant risk to underground mine personnel, equipment, and infrastructure. Method: Thirty-six naive participants were randomly assigned to first- and second-order conditions and completed three experimental trials comprising sequences of 90° turns in a virtual underground mine environment, with velocity held constant at 9 km/h−1. Performance measures were lateral deviation, steering angle variability, high-frequency steering content, joystick activity, and cumulative time in collision with the virtual mine wall. Results: The second-order control group exhibited significantly poorer performance for all outcome measures. In addition, a series of correlation analyses revealed that changes in strategy were evident in the second-order group but not the first-order group. Conclusion: Results were consistent with previous literature indicating poorer performance with higher-order control devices and caution against the adoption of the second-order joystick system for underground shuttle cars. Application: Low-cost, portable simulation platforms may provide an effective basis for operator training and recruitment.
The Effect of Mild Motion Sickness and Sopite Syndrome on Multitasking Cognitive Performance
Authors: Matsangas Panagiotis , McCauley Michael E. , Becker William 
Published: February 2014

Objective: In this study, we investigated the effects of mild motion sickness and sopite syndrome on multitasking cognitive performance. Background: Despite knowledge on general motion sickness, little is known about the effect of motion sickness and sopite syndrome on multitasking cognitive performance. Specifically, there is a gap in existing knowledge in the gray area of mild motion sickness. Method: Fifty-one healthy individuals performed a multitasking battery. Three independent groups of participants were exposed to two experimental sessions. Two groups received motion only in the first or the second session, whereas the control group did not receive motion. Measurements of motion sickness, sopite syndrome, alertness, and performance were collected during the experiment. Results: Only during the second session, motion sickness and sopite syndrome had a significant negative association with cognitive performance. Significant performance differences between symptomatic and asymptomatic participants in the second session were identified in composite (9.43%), memory (31.7%), and arithmetic (14.7%) task scores. The results suggest that performance retention between sessions was not affected by mild motion sickness. Conclusion: Multitasking cognitive performance declined even when motion sickness and soporific symptoms were mild. The results also show an order effect. We postulate that the differential effect of session on the association between symptomatology and multitasking performance may be related to the attentional resources allocated to performing the multiple tasks. Results suggest an inverse relationship between motion sickness effects on performance and the cognitive effort focused on performing a task. Application: Even mild motion sickness has potential implications for multitasking operational performance.
Differences in limb, age and sex of Chinese deep vein thrombosis patients
Authors: Chen Feng , Xiong Ji Xin , Zhou Wei Min 
Published: February 2014

Objective Recently, the differences in age or sex of deep vein thrombosis (DVT) patients have been widely debated. However, close analyses of the differences in limb, age and sex of Chinese DVT patients have been scarcely reported. The purpose of this research is to study the differences in limb, age and sex of DVT patients. Methods A total of 783 consecutive DVT patients were retrospectively reviewed. Patients with an acute presentation of DVT were diagnosed by means of compression ultrasonography or venography. Clinical characteristics and provoked risk factors were analyzed. Results There were three frequency peaks including two smaller peaks at age 20–24 and 70–74 years, and the largest peak at age 45–59 years. The most significant risk factors affecting different age groups were as follows: pregnancy/puerperium for age ≤39; fracture and hysterectomy for age 40–64; fracture and malignancy for age ≥65. DVT frequency rate provoked by malignancy was higher in right DVT than left DVT (15.8% vs. 4.6%; p < 0.001). Left DVT was more common than right DVT (582 vs. 158). Left DVT tended to occur in females (male:female, 40.5%:59.5%), and right DVT in males (male:female, 74.7%:25.3%). DVT provoked by pregnancy/puerperium (56/63, 88.9%) or hysterectomy (27/30, 90.0%) was mostly located in left limb. Conclusion It is necessary to pay more attention to thromboprophylaxis for patients with the risk factors of pregnancy/puerperium, hysterectomy, fracture and malignancy, especially those over the age of 65. And further research into the cause of limb, age and sex differences in DVT occurrence is needed.
Impact of Platelet Functional Assays on the Cost of Treating Suspected Heparin-Induced Thrombocytopenia
Authors: Sadik Ziad G. , Jennings Douglas L. , Nemerovski Carrie W. , Kuriakose Philip , Kalus James S. 
Published: February 2014

Objectives: To investigate the potential cost savings of using functional platelet assays to confirm the diagnosis of heparin-induced thrombocytopenia (HIT). Methods: This was a single-center study conducted in the United States. We performed a retrospective cost of illness analysis of suspected HIT, comparing patients with the serotonin release assay (SRA) ordered as part of their diagnostic evaluation to those who did not. The primary clinical end point was a composite of mortality and major bleed. Results: A total of 147 patients met the study’s inclusion criteria. An SRA was ordered in 53 patients of whom 17% were positive. Overall, SRA use did not reduce the composite primary clinical end point (32.1% vs 33%, P = .911). Also, there was no difference in the total cost of hospital stay (US $84781.1 vs US $78534.4, P = .409) nor in the direct medical costs related to HIT management (US $7473.5 vs US $8402.4, P = .393). Early ordering of the SRA (within 48 hours) was associated with shorter length of stay (20 vs 27 days, P = .029) but without a difference in cost of treatment. Conclusion: The use of SRA did not reduce the costs or improve clinical outcomes in patients with suspected HIT.
Cytokines in relation to autoantibodies before onset of symptoms for systemic lupus erythematosus
Authors: Eriksson C , Rantapää-Dahlqvist S 
Published: February 2014

Objectives A number of cytokines and chemokines were analysed and related to autoantibodies in blood samples pre-dating the onset of symptoms of systemic lupus erythematosus. Methods Thirty-five patients with systemic lupus erythematosus (American College of Rheumatology criteria) were identified as having donated blood samples, prior to symptom onset, to the Biobank of northern Sweden. Altogether, 140 age- and sex-matched controls were also identified. The concentrations of interferon-α, interleukin-4, interleukin-9, interleukin-10, interferon inducible protein-10 and monocyte chemotactic protein-1 were analysed using multiplex technology and related to autoantibodies (ANA, ENA, anti-dsDNA and anti-histone antibodies) analysed from the same blood sample. Results The interferon-γ inducible protein-10 levels were higher in the pre-symptomatic individuals than in controls ( p < 0.05) and correlated with interferon-α ( p < 0.01). The interferon-γ inducible protein-10 and interferon-α concentrations were significantly increased in individuals positive for autoantibodies: interferon-γ inducible protein-10 for ANA; anti-SSA/Ro and anti-Jo-1 antibodies; interferon-α with anti-SSB/La antibodies. The levels of interleukin-10, interferon-γ inducible protein-10 and monocyte chemotactic protein-1 increased significantly from the pre-symptomatic individuals to after onset of systemic lupus erythematosus. Conclusions An increased concentration of interferon-γ inducible protein-10 pre-dated the onset of systemic lupus erythematosus and was related to autoantibodies before the onset of disease. The levels of interferon-γ inducible protein-10 and interferon-α were correlated. These findings support the proposal that the interferon system is important early in the pathogenesis of systemic lupus erythematosus and autoantibody formation.
Short-Term Stability of Amino acids and Acylcarnitines in the Dried Blood Spots Used to Screen Newborns for Metabolic Disorders
Authors: Golbahar J , Altayab DD , Carreon E 
Published: February 2014

Objective Tandem mass spectrometry is increasingly used in the Middle East in newborn screening for inborn errors of metabolism using dried blood spots. The sensitivity and specificity of this system for analyzing fatty and amino acids, screening for more than 40 metabolic conditions, is known. However, the short term stability of acylcarnitines and amino acids in dried blood spots in extreme heat and humid conditions is not well documented. We examined the short term effect of heat and humidity on the levels of 7 amino acids and 10 acylcarnitines used in newborn screening for inherited metabolic disorders. Methods Dried blood spots were exposed with humidity <30% to temperatures of 4℃, room temperature, 37° C, and 45℃, and also with humidity >70% at 37° C and 45℃. Amino acids and acylcarnitines in the dried blood spots were analyzed by tandem mass spectrometry. Results During the eight days of the study in high temperature and high humidity storage, most acylcarnitines and amino acids lost almost 50% of initial concentration. After eight days’ exposure at 37℃ and 45℃ with humidity >70%, methionine was determined to be the most sensitive, and phenylalanine and leucine were the least sensitive amino acids. At 37℃ with humidity >70% C6 was the most sensitive and free carnitine (C0) was the least sensitive acylcarnitine; at 45℃ with humidity >70% C16 was the most sensitive and C0 was the least sensitive. Conclusion Low humidity and low temperature conditions are required for transportation and storage of dried blood spots.