bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lanthanide Circularly Polarized Luminescence: Bases and Applications
Authors: Zinna Francesco , Di Bari Lorenzo 
Published: October 2014

AbstractLanthanide (III) luminescence is very characteristic: it is characterized by narrow emission bands, large Stokes shift, and a long excited state lifetime. Moreover, chiral lanthanide complexes can emit strongly circularly polarized light in a way that is almost precluded to purely organic molecules. Thanks to the sensitivity and specificity of the Ln circularly polarized luminescence (CPL) signal, CPL‐active complexes are therefore employed as bioanalytical tools and other uses can be envisaged in many other fields. Here we present a brief overview of the most recently developed CPL‐active lanthanide complexes and a selected few examples of their applications. We briefly discuss the main mechanisms that can rationalize the observed outstanding CPL properties of these systems, and some practical suggestions on how to measure and report data. Chirality 27:1–13, 2015. © 2014 Wiley Periodicals, Inc.
High performance computing of oligopeptides complete backtranslation applied to DNA microarray probe design
Authors: Jaziri Faouzi , Peyretaillade Eric , Peyret Pierre , Hill David R.C. 
Published: October 2014

SummaryComplete backtranslation is the step of generating all possible nucleic acid sequences from a protein sequence. This is a time‐consuming task that can provide unreasonable quantities of data. Complete backtranslation was recently used to initiate probe design for functional DNA microarrays from conserved peptidic regions, in order to assess the full microbial gene diversity present in complex environments. In this article, we present an efficient parallelization method to compute a complete backtranslation of short peptides to select probes for functional microarrays. We implemented a software that uses meta‐programming and a model‐driven engineering approach to automatically generate source codes to perform complete backtranslation on different architectures: PCs, Symmetric Multiprocessors servers, computing clusters, or a computing grid. Our software is filtering the generated oligonucleotides with usual selection criteria for the design of microarray probes. It uses load balancing and can be easily integrated in probe design software for functional microarrays. We present its performance on both simulated and real biological datasets. The obtained results show a significant computing speedup on different platforms and an important gain of about 40% of disk space when filtering oligonucleotides. Copyright © 2014 John Wiley & Sons, Ltd.
PENNANT: an unstructured mesh mini‐app for advanced architecture research
Authors: Ferenbaugh Charles R. 
Published: October 2014

SUMMARYThis paper describes PENNANT, a mini‐app that operates on general unstructured meshes (meshes with arbitrary polygons), and is designed for advanced architecture research. It contains mesh data structures and physics algorithms adapted from the Los Alamos National Laboratory radiation‐hydrodynamics code FLAG and gives a sample of the typical memory access patterns of FLAG. The basic capabilities and optimization approaches of PENNANT are presented. Results are shown from sample performance experiments run on serial, multicore, and graphics processing unit implementations, giving an indication of how PENNANT can be a useful tool for studies of new architectures and programming models. Copyright © 2014 John Wiley & Sons, Ltd.
Body Image as a Source of Shame: A New Measure for the Assessment of the Multifaceted Nature of Body Image Shame
Authors: Duarte Cristiana , Pinto‐Gouveia José , Ferreira Cláudia , Batista Diana 
Published: October 2014

Theoretical and empirical accounts highlight the link between shame and body image difficulties, and disordered eating behaviours. Specifically, body image shame seems to play a particularly important role in this association. The current study aimed at developing and validating a new measure of body image shame and its phenomenology, the Body Image Shame Scale (BISS).Distinct samples of women from the general and student populations were used to test the BISS factorial structure using principal component analysis (PCA) and confirmatory factor analysis (CFA), and to examine the psychometric properties of the BISS.Principal component analysis results indicated that the scale presents a two‐factor structure assessing an externalized and an internalized dimension underlying body image shame, which explains a total of 62.41% of the variance. A confirmatory factor analysis further corroborated the adequacy of this structure, which revealed good global and local adjustment indices. The BISS also presented very good internal consistency, construct and discriminant validities and good test–retest reliability. The scale also showed good concurrent and divergent validities. Furthermore, the scale discriminates between women with higher or lower levels of disordered eating behaviours. Finally, a mediation analysis revealed that the BISS fully mediates the previously established association between external shame and eating psychopathology.The BISS is a psychometrically robust and short measure of body image shame and its external and internal dimensions. Copyright © 2014 John Wiley & Sons, Ltd.Key Practitioner MessageThe BISS is a brief and reliable self‐report instrument of body image‐related shame.The BISS assesses the phenomenology of body image shame considering an externalized dimension and an internalized dimension, which may have important clinical implications.The BISS presents very good internal consistency, construct and discriminant validities, test–retest reliability, concurrent and divergent validities, and accurately distinguishes between women with higher and normative levels of disordered eating behaviours.Body image shame, as assessed by the BISS, contributes to a better understanding of eating psychopathology with findings suggesting that the association between external shame and eating psychopathology fully depends on the extent to which one's body image becomes the source of shame, with the consequent activation of defensive attitudes and behaviours.
Cooperative detection and protection for Interest flooding attacks in named data networking
Authors: Ding Kun , Liu Yun , Cho Hsin‐Hung , Chao Han‐Chieh , Shih Timothy K. 
Published: October 2014

SummaryNamed data networking (NDN) is a new emerging architecture for future network, which may be a substitute of the current TCP/IP‐based network, for the content‐oriented data request mode becoming the future trend of development. The security of NDN has attracted much attention, as an implementation of next‐generation Internet architecture. Although NDN is immune to most current attack, it cannot resist the distributed denial of service like attack – Interest flooding attack (IFA) – effectively. IFA takes advantages of the forwarding mechanism of NDN, flooding a large number of malicious Interest packets at quite a high rate, and exploits the network resources, which may cause the paralysis of the network. Taking into account the severity of the destruction, we propose an algorithm to counter such new type of attack. We analyze three properties of IFA, and use them to judge and filter Interest packets. Vector space model and Markov model are used in our method to realize a cooperative detection. Meanwhile, we present the retransmission forwarding mechanism to ensure legitimate user request. The ndnSIM module of ns3 is used for the corresponding simulation, and results of the simulation will be given to show the effectiveness of our algorithm. Copyright © 2014 John Wiley & Sons, Ltd.
Mono‐Oxido‐Bridged Heterobimetallic and Heterotrimetallic Compounds Containing Titanium(IV) and Chromium(III)
Authors: Huang Tao , Wu Xinyuan , Weare Walter W. , Sommer Roger D. 
Published: October 2014

AbstractA series of oxido‐bridged heterobi‐ and heterotrimetallic complexes, [(tmtaa)Ti=O→Cr(Por)Cl] and [(tmtaa)Ti=O→Cr(Por)←O=Ti(tmtaa)]+ (tmtaa = 7,16‐dihydro‐6,8,15,17‐tetramethyldibenzo[b,i][1,4,8,11]tetraazacyclotetradecine; Por = 5,10,15,20‐tetraarylporphyrin), have been synthesized. To the best of our knowledge, these complexes are the first structurally characterized examples to contain a Ti=O→Cr or Ti=O→Cr←O=Ti structural motif. Crystal structures of representative heterobimetallic compounds, including the Ti=O→Cr binuclear complex 2 and two separate trimers, [Ti=O→Cr←O=Ti]SbF6 (10) and [Ti=O→Cr←O=Ti]Cl (12), are reported. The bi‐ and trimetallic molecules have similar structural parameters, including Ti–O, Cr–O, and Ti–O–Cr bond lengths and angles with a linear Ti=O→Cr geometry. Magnetic studies showed that a high‐spin CrIII (S = 3/2) center is present in both the bi‐ and trinuclear molecules. The redox potentials for CrIV/III (ΔE = 320 mV) and Por/Por·– (ΔE = 260 mV) can be tuned by modifying the porphyrin ligand. By determining the thermodynamics and kinetics of the formation of these complexes by titration experiments and electrochemistry, it was found that the bi‐ and trimetallic species undergo isomerization in solution, allowing easy substitution of the apical chlorido ligand.
Electrochemical Behavior of Nicotine at Unmodified Carbon Paste Electrode and Its Determination in a Set of Refilling Liquids for Electronic Cigarettes
Authors: Stočes Matěj , Švancara Ivan 
Published: October 2014

AbstractIn this manuscript, a carbon paste electrode (CPE) from traditional components has been used to study the electrochemical oxidation of nicotine and its feasibility to be performed at unmodified and otherwise untreated carbon paste in an effort to propose a simple voltammetric method for the determination of nicotine in samples of refilling liquids for electronic cigarettes. As found out, irreversible oxidation of nicotine at CPE had occurred at −0.95 V vs. Ag/AgCl as a diffusion‐controlled process, when suitable pH for this redox transformation was either a neutral supporting medium (phosphate buffer, pH 7.5) or mild alkaline solution (of Britton‐Robinson buffer, pH 11). After having chosen the SWV mode and optimizing the key instrumental and electroanalytical parameters, the oxidation response of the substance of interest has been fairly proportional to concentration in the range of 50–500 µmol L−1 in phosphate buffer or even 50–1000 µmol L−1 in BrittonRobinson buffer. And if the reproducibility could substantially be improved by incorporating an effective conditioning step, the method could be applied for the determination of nicotine in real samples of refilling liquids for electronic cigarette with satisfactory results corresponding well to the values declared by manufacturer.
TOXOR: Design and Application of an Electrochemical Toxicity Biosensor for Environmental Monitoring
Authors: O'Hara Tony , Seddon Brian , McClean Siobhán , Dempsey Eithne 
Published: October 2014

AbstractHere we present design and assay methodology of a novel electrochemical biosensor with the view to assess cytotoxic effects of key chemicals. The concept is based on mammalian cells as the biological recognition agent (A549 human lung epithelial cells) and measures changes in cellular enzyme activity (acid phosphatase – AP) following 24 hours exposure. AP catalyses the dephosphorylation of 2‐naphthyl phosphate to 2‐naphthol (determined using chronocoulometry) and is indicative of metabolically active cells. Immobilised living cells exposed to pentachlorophenol, cadmium chloride and nickel chloride exhibited a decrease in AP activity which enabled IC50 (50 % reduction in enzyme activity) values of toxic chemicals to be reliably and conveniently determined using electronic detection. The IC50 values obtained for CdCl2 and NiCl2 (65 and 330 µM) were in agreement with those found using the standard MTT cytotoxicity assay (100 and 350 µM). In the case of pentachlorophenol, the value obtained (60 µM) was lower (MTT assay IC50 value>160 µM) suggesting enhanced sensitivity of the electrochemical assay towards pentachlorophenol. It is envisaged that this device could be exploited in the screening of industrial and environmental toxins and has potential in drug testing applications.
Stochastic simulation of regionalized ground motions using wavelet packets and cokriging analysis
Authors: Huang Duruo , Wang Gang 
Published: October 2014

SummaryPerformance‐based earthquake engineering often requires ground‐motion time‐history analyses to be performed, but very often, ground motions are not recorded at the location being analyzed. The present study is among the first attempt to stochastically simulate spatially distributed ground motions over a region using wavelet packets and cokriging analysis. First, we characterize the time and frequency properties of ground motions using the wavelet packet analysis. The spatial cross‐correlations of wavelet packet parameters are determined through geostatistical analysis of regionalized ground‐motion data from the Northridge and Chi‐Chi earthquakes. It is observed that the spatial cross‐correlations of wavelet packet parameters are closely related to regional site conditions. Furthermore, using the developed spatial cross‐correlation model and the cokriging technique, wavelet packet parameters at unmeasured locations can be best estimated, and regionalized ground‐motion time histories can be synthesized. Case studies and blind tests using data from the Northridge and Chi‐Chi earthquakes demonstrate that the simulated ground motions generally agree well with the actual recorded data. The proposed method can be used to stochastically simulate regionalized ground motions for time‐history analyses of distributed infrastructure and has important applications in regional‐scale hazard analysis and loss estimation. Copyright © 2014 John Wiley & Sons, Ltd.
Testing an application of a biotic ligand model to predict acute toxicity of metal mixtures to rainbow trout
Authors: Iwasaki Yuichi , Kamo Masashi , Naito Wataru 
Published: October 2014

Abstract

The authors tested the applicability of a previously developed biotic ligand model (BLM) to predict acute toxicity of single metals and metal mixtures (cadmium, lead, and zinc) to rainbow trout fry (Oncorhynchus mykiss) from a single available dataset. The BLM used in the present study hypothesizes that metals inhibit an essential cation (calcium) and organisms die as a result of its deficiency, leading to an assumption that the proportion of metal-binding ligand (f) is responsible for the toxic effects of metals on the survival of rainbow trout. The f value is a function of free-ion concentrations of metals computed by a chemical speciation model, and the function has affinity constants as model parameters. First, the survival effects of single metals were statistically modeled separately (i.e., f-survival relationship) by using the generalized linear mixed model with binomial distribution. The modeled responses of survival rates to f overlapped reasonably irrespective of metals tested, supporting the theoretical prediction from the BLM that f-survival relationships are comparable regardless of metal species. The authors thus developed the generalized linear mixed model based on all data pooled across the single-metal tests. The best-fitted model well predicted the survival responses observed in mixture tests (r = 0.97), providing support for the applicability of the BLM to predict effects of metal mixtures. Environ Toxicol Chem 2015;34:754–760. © 2014 SETAC
Modeling PCB transfer into hen eggs: Influence of physiological characteristics of the animal
Authors: Fournier Agnès , Martin Olivier , Travel Angélique , Puillet Laurence , Feidt Cyril , Jondreville Catherine 
Published: October 2014

Abstract

Laying hens are likely to be exposed to a wide range of persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs). To improve the safety of poultry farming systems in terms of POPs, the present research focused on assessing the impact of physiological characteristics of the hen on the transfer of ingested PCBs to eggs. Modeling was used as a research tool to explore the impact of some physiological characteristics on the transfer of PCBs in the laying hen. The mathematical model simulates the dynamics of the size of the lipid compartments in the animal and the frequency of laying, with the PCB concentrations in egg yolk and adipose tissue being model outputs. Simulations were run to assess effects of animal characteristics on the transfer of PCBs to eggs. Laying rate proportionally influenced the PCB level of eggs and adipose tissue at steady state. Body fat diluted absorbed PCBs in the absence of laying and significantly influenced the decontamination rate of tissues during depuration after an exposure period. Application of the present model to actual exposure cases highlights its value in improving the support of risk management in livestock farming. Environ Toxicol Chem 2015;34:173–183. © 2014 SETAC
Perfluoroalkyl substance concentrations in a terrestrial raptor: Relationships to environmental conditions and individual traits
Authors: Bustnes Jan O. , Bangjord Georg , Ahrens Lutz , Herzke Dorte , Yoccoz Nigel G. 
Published: October 2014

Abstract

Accumulation of persistent organic pollutants (POPs) in wildlife may be influenced by the physical and biotic environment, and concentrations vary greatly among areas, seasons, and individuals. Different hypotheses about sources of variation in perfluoroalkyl substance (PFAS) concentrations were examined in eggs (n = 107) of tawny owls (Strix aluco) collected over a 24-yr period (1986–2009) in Norway. Predictor variables included the North Atlantic Oscillation (NAO), temperature, snow, food availability (vole abundance), and individual traits such as age, body condition, and clutch size. Concentrations of both perfluoro-octane sulfonate (PFOS) and perfluoroalkyl carboxylates (PFCAs) varied several fold in the population, both inter- and intra-annually. Moreover, individuals laid eggs with several times higher or lower PFAS concentrations within few years (1 yr–5 yr). After controlling for temporal trends (i.e., declining PFOS and increasing PFCA concentrations), both PFOS and PFCAs were positively associated to the winter NAO in the previous year (NAOy – 1), suggesting that atmospheric transport may be affecting the input of PFASs to the local ecosystem. Perfluoro-octane sulfonate was negatively related to temperature, but the pattern was complex as there was an interaction between temperature and the feeding conditions. The PFOS accumulation was highest in years with high vole abundance and low to medium temperatures. For PFCAs, there was an interaction between NAOy – 1 and feeding conditions, suggesting that strong air transport toward Norway and high consumption of voles led to a moderate increase in PFCA accumulation. The individual traits, however, had very little impact on the concentrations of PFASs in the eggs. The present study thus suggests that annual variation in environmental conditions influences the concentrations of PFASs in a terrestrial raptor such as the tawny owl. Environ Toxicol Chem 2015;34:184–191. © 2014 SETAC
Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population
Authors: Mizuki Yutaka , Takaki Manabu , Okahisa Yuko , Sakamoto Shinji , Kodama Masafumi , Ujike Hiroshi , Uchitomi Yosuke 
Published: October 2014

ObjectiveThe human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene is one of the candidate genes for type 2 diabetes mellitus (T2DM). ARHGEF11 is mapped to chromosome 1q21, which has susceptible risk loci for T2DM and schizophrenia. We hypothesized that ARHGEF11 contributes to the pathogenesis of schizophrenia.MethodWe selected eight single nucleotide polymorphisms of ARHGEF11 that had significant associations with T2DM for a case‐control association study of 490 patients with schizophrenia and 500 age‐matched and sex‐matched controls.ResultsWe did not find any differences in allelic, genotypic associations, or minor allele frequencies with schizophrenia. Analysis of the rs6427340‐rs6427339 haplotype and the rs822585‐rs6427340‐rs6427339 haplotype combination provided significant evidence of an association with schizophrenia (global permutations p = 0.00047 and 0.0032, respectively). C‐C of the rs6427340‐rs6427339 haplotype and A‐C‐C of the rs822585‐rs6427340‐rs6427339 haplotype carried higher risk factors for schizophrenia (permutation p = 0.0010 and 0.0018, respectively). A‐C‐T of the rs822585‐rs6427340‐rs6427339 haplotype had a possible protective effect (permutation p = 0.031).ConclusionThese results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia. Copyright © 2014 John Wiley & Sons, Ltd.
Idiosyncratic deals in contemporary organizations: A qualitative and meta‐analytical review
Authors: Liao Chenwei , Wayne Sandy J. , Rousseau Denise M. 
Published: October 2014

SummaryIdiosyncratic deals (i‐deals) research focuses on the emergence of customized work arrangements employees negotiate with their employers. This article provides a critical review and synthesis of i‐deals research, combining a qualitative review of i‐deals theory and research with a supplementary meta‐analysis of 23 empirical studies (k = 27 samples, N = 8110 individuals). The qualitative review examines the conceptualization and measurement of i‐deals and identifies patterns and gaps in i‐deals research, while the quantitative meta‐analysis tests the moderating effect of societal cultures on the predictors and consequences of ideals investigated to date. In each section, attention is given to strengths and weaknesses of current approaches to i‐deals theory and research. Future research directions are identified with particular emphasis on the largely unexamined role of i‐deals from a multilevel perspective. Copyright © 2014 John Wiley & Sons, Ltd.
Meta‐analysis of lobectomy, segmentectomy, and wedge resection for stage I non‐small cell lung cancer
Authors: Zhang Yang , Sun Yihua , Wang Rui , Ye Ting , Zhang Yiliang , Chen Haiquan 
Published: October 2014

BackgroundSurvival difference following lobectomy, segmentectomy, and wedge resection in stage I non‐small cell lung cancer (NSCLC) and its subgroups remains undetermined.MethodsWe systemically searched published articles comparing recurrence‐free survival (RFS), overall survival (OS), or cancer‐specific survival (CSS) between lobectomy and limited resection or between segmentectomy and wedge resection.ResultsA total of 42 studies published from 1980 to 2014 enrolling 21,926 patients were included in this meta‐analysis. Survival results favored lobectomy in stage IA NSCLC ≤2 cm (combined HR: 1.530, 95% CI: 1.402–1.671, P < 0.001) or patient's ≥65 years old (combined HR: 1.227, 95% CI: 1.003–1.502, P = 0.047). Survival outcome of video‐assisted thoracoscopic (VATS) sublobectomy was comparable to that of VATS lobectomy (pooled HR: 0.808, 95% CI: 0.556–1.174, P = 0.263). The combined HR of segmentectomy versus lobectomy was 1.231 (95% CI: 1.070–1.417, P = 0.004), while the pooled HR of wedge resection versus segmentectomy was 1.542 (95% CI: 0.856–2.780, P = 0.149).ConclusionsThis study suggested that tumor size or age alone should not be the criteria to encourage sublobar resection. For stage I NSCLC, survival following segmentectomy was inferior to lobectomy. Patients undergoing intentional sublobectomy achieved comparable survival as those who received lobectomy. J. Surg. Oncol. 2015 111:334–340. © 2014 Wiley Periodicals, Inc.