bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Short and Highly Convergent Approach for the Synthesis of Rutaecarpine Derivatives.
Authors: Subba Reddy B. V. , Anji Babu R. , Jagan Mohan Reddy B. , Sridhar B. , Ramalinga Murthy T. , Pranathi P. , Kalivendi Shasi V. , Prabhakar Rao T. 
Published: July 2015

AbstractQuinazolinoisoquinolines and benzimidazocarbolines are simply and conveniently synthesized by the condensation of anthranilamide or phenylenediamine derivatives, resp., with chloroaldehydes (I).
ChemInform Abstract: Gold‐Catalyzed Formation of Pyrrolo‐ and Indolo‐oxazin‐1‐one Derivatives: The Key Structure of Some Marine Natural Products.
Authors: Taskaya Sultan , Menges Nurettin , Balci Metin 
Published: July 2015

Abstract3,4‐Dihydropyrrolo‐ and indolo‐oxazin‐1‐one derivatives are efficiently obtained by cyclization reactions of corresponding N‐propargylpyrrole and ‐indolecarboxylic acids, respectively.
ChemInform Abstract: TBAI‐Catalyzed Oxidative Cross‐Coupling of Phenols and 2‐Aminoacetophenones.
Authors: Xu Wei , Nachtsheim Boris J. 
Published: July 2015

AbstractVarious α‐phenoxylated 2‐aminoacetophenones such as (III) and (V) are obtained by iodide‐catalyzed intermolecular cross‐coupling of α‐aminoacetophenones with phenols.
ChemInform Abstract: Highly Selective Hydrothiolation of Unsaturated Organosilicon Compounds Catalyzed by Scandium(III) Triflate.
Authors: Kucinski Krzysztof , Pawluc Piotr , Marciniec Bogdan , Hreczycho Grzegorz 
Published: July 2015

AbstractThe hydrothiolation of allylsilanes with aromatic and aliphatic thiols proceeds under mild conditions to give the Markovnikov regioisomer as main product.
ChemInform Abstract: Ricinodols A—G: New Tetracyclic Triterpenoids as 11β‐HSD1 Inhibitors from Ricinodendron heudelotii.
Authors: Yu Jin‐Hai , Shen Yu , Wu Yan , Leng Ying , Zhang Hua , Yue Jian‐Min 
Published: July 2015

AbstractAll ricidinols exhibit an inhibitory effect on human and mouse 11β‐HSD1 with ricinodol E (V) showing the strongest effect.
ChemInform Abstract: Pd‐Catalyzed Directed ortho‐C—H Alkenylation of Phenylalanine Derivatives.
Authors: Garcia‐Rubia Alfonso , Laga Eduardo , Cativiela Carlos , Urriolabeitia Esteban P. , Gomez‐Arrayas Ramon , Carretero Juan C. 
Published: July 2015

AbstractThe reaction proceeds under exclusive formation of the E isomers and can also be applied in the synthesis of norephedrin derivatives (XIV).
Combined heat and mass transfer of third‐grade nanofluids over a convectively‐heated stretching permeable surface
Authors: Khan Waqar A. , Culham J. Richard , Makinde O. Daniel 
Published: July 2015

AbstractThe buoyancy‐induced flows of third‐grade nanofluids are investigated along a vertical permeable stretching sheet, and a numerical solution is obtained for the combined heat and mass transfer during convective cooling of the stretching sheet, subject to partial slip and convective solutal boundary conditions. The Cauchy stress tensor for the fluids of grade three and Buongiorno model for the nanofluids are used in the governing equations. The model is capable of investigating the flow, heat, and mass characteristics of third‐grade nanofluids along the stretching sheet. The partial differential equations are converted into ordinary nonlinear differential equations and are solved using a second‐order numerical technique which includes a finite difference scheme and shooting method. The effects of the buoyancy, third‐grade, viscoelastic, partial slip, convective heat and mass transfer, and nanofluid parameters on the dimensionless velocity, temperature, concentration, skin friction, and heat and mass transfer rates are reported. The present results of skin friction and heat and mass transfer rates are compared with published data, and are found to be in close agreement.
Is Heart Rate Variability Related to Season of Birth?
Authors: Huang Wei‐Lieh , Hwang Be‐Tau , Lai Chun‐Ting , Li Jia‐Yi , Kuo Terry B.J. , Yang Cheryl C.H. 
Published: July 2015

ABSTRACTBackgroundSeason of birth (SOB) has been found to be related to cardiovascular mortality, but the mechanisms are unclear. It is suggested that birth in winter is a protective factor for the circulatory system, and this should be able to be observed using heart rate variability (HRV) measurements. The phenomenon may have a sex difference and is likely to be modulated by climatic factors. This study focused on this problem and investigates healthy school‐age children to minimize confounding factors.HypothesisBirth in winter is protective to cardiovascular system via autonomic modulation. There is a gender difference in the relationship between SOB and autonomic activity. Climatic factors are the cause of SOB effects on autonomic system.MethodsA total of 381 healthy school‐age children were recruited for this study. Their HRV profiles were measured once and climatic information related to their month of birth was gathered. The HRV profiles of the 2 sexes and 4 seasons of birth were compared. Correlation and regression analysis were performed to clarify the relationship between climatic factors and the HRV results.ResultsBoys born in winter have higher high‐frequency power (HF) but a lower ratio of low‐frequency power to high‐frequency power (LF/HF) than do males born in other seasons. This result is not found for girls. Age and the temperature of the SOB are predictive factors for HF among boys. The humidity of SOB is a predictive factor for normalized low‐frequency power (LF%) and LF/HF among girls.ConclusionsSeason of birth is related to both parasympathetic and sympathetic activity among school‐age children, especially boys. Temperature and humidity are potential causes of this SOB phenomenon.
Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long‐tErm follow‐uP of antithrombotic management patterns In Acute CORonary Syndrome patients in Asia)
Authors: Huo Yong , Lee Stephen W.‐L. , Sawhney Jitendra P. S. , Kim Hyo‐Soo , Krittayaphong Rungroj , Nhan Vo T. , Alonso‐Garcia Angeles , Han Ya Ling , Ge Junbo , Chin Chee Tang , Ong Tiong K. , Jan Stephen , Itoh Yohji , Vega Ana Maria , Pocock Stuart 
Published: July 2015

ABSTRACTBackgroundIn‐hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real‐life antithrombotic management patterns (AMPs) and ACS‐related outcomes in Asia is unclear.MethodsEPICOR Asia (Long‐tErm follow‐uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2‐year follow‐up. The aim is to describe short‐ and long‐term (up to 2 years post–index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self‐reported health status. Pre‐ and in‐hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2‐year follow up.ResultsBetween June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208).ConclusionsEPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self‐reported health status both during hospitalization and up to 2 years after discharge will also be described.
Novel Triazolopyrimidine‐Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases
Authors: Nettekoven Matthias , Adam Jean‐Michel , Bendels Stefanie , Bissantz Catarina , Fingerle Jürgen , Grether Uwe , Grüner Sabine , Guba Wolfgang , Kimbara Atsushi , Ottaviani Giorgio , Püllmann Bernd , Rogers‐Evans Mark , Röver Stephan , Rothenhäusler Benno , Schmitt Sebastien , Schuler Franz , Schulz‐Gasch Tanja , Ullmer Christoph 
Published: July 2015

AbstractThe cannabinoid receptor 2 (CB2) system is described to modulate various pathological conditions, including inflammation and fibrosis. A series of new heterocyclic small‐molecule CB2 receptor agonists were identified from a high‐throughput screen. Lead optimization gave access to novel, highly potent, and selective (over CB1) triazolopyrimidine derivatives. A preliminary structure–activity relationship was established, and physicochemical properties in this compound class were significantly improved toward better solubility, lipophilicity, and microsomal stability. An optimized triazolopyrimidine derivative, (3S)‐1‐[5‐tert‐butyl‐3‐[(1‐cyclopropyltetrazol‐5‐yl)methyl]triazolo[4,5‐d]pyrimidin‐7‐yl]pyrrolidin‐3‐ol (39), was tested in a kidney ischemia–reperfusion model, in which it showed efficacy at a dose of 10 mg kg−1 (p.o.). A significant depletion of the three measured kidney markers indicated a protective role of CB2 receptor activation toward inflammatory kidney damage. Compound 39 was also protective in a model of renal fibrosis. Oral treatment with 39 at 3 mg kg−1 per day significantly decreased the amount of fibrosis by ∼40 % which was induced by unilateral ureter obstruction.
Long‐term sustained disease control in patients with mantle cell lymphoma with or without active disease after treatment with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
Authors: Vaughn Jennifer E. , Sorror Mohamed L. , Storer Barry E. , Chauncey Thomas R. , Pulsipher Michael A. , Maziarz Richard T. , Maris Michael B. , Hari Parameswaran , Laport Ginna G. , Franke Georg N. , Agura Edward D. , Langston Amelia A. , Rezvani Andrew R. , Storb Rainer , Sandmaier Brenda M. , Maloney David G. 
Published: July 2015

BACKGROUNDPreviously, early results were reported for allogeneic hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning with 2 Gy of total body irradiation with or without fludarabine and/or rituximab in 33 patients with mantle cell lymphoma (MCL).METHODSThis study examined the outcomes of 70 patients with MCL and included extended follow‐up (median, 10 years) for the 33 initial patients. Grafts were obtained from human leukocyte antigen (HLA)–matched, related donors (47%), unrelated donors (41%), and HLA antigen–mismatched donors (11%).RESULTSThe 5‐year incidence of nonrelapse mortality was 28%. The relapse rate was 26%. The 5‐year rates of overall survival (OS) and progression‐free survival (PFS) were 55% and 46%, respectively. The 10‐year rates of OS and PFS were 44% and 41%, respectively. Eighty percent of surviving patients were off immunosuppression at the last follow‐up. The presence of relapsed or refractory disease at the time of HCT predicted a higher rate of relapse (hazard ratio [HR], 2.94; P = .05). Despite this, OS rates at 5 (51% vs 58%) and 10 years (43% vs 45%) were comparable between those with relapsed/refractory disease and those undergoing transplantation with partial or complete remission. A high‐risk cytomegalovirus (CMV) status was the only independent predictor of worse OS (HR, 2.32; P = .02). A high‐risk CMV status and a low CD3 dose predicted PFS (HR, 2.22; P = .03).CONCLUSIONSNonmyeloablative allogeneic HCT provides a long‐term survival benefit for patients with relapsed MCL, including those with refractory disease or multiple relapses. Cancer 2015;121:3709–3716. © 2015 American Cancer Society.
Utilization of workflow management system for virtual machine instance management on cloud
Authors: Kim Huioon , Chun Kyungwon , Kim Hyounggyu , Chung Youngjoo 
Published: July 2015

SummaryThe concept of virtualization is one of the most important technologies to construct a cloud service, and especially hardware virtualization is indispensable for infrastructure as a service (IaaS) where the cloud offering, infrastructure, is usually provided as a pool of virtual machine (VM) instances. For that reason, many public IaaS clouds like Amazon Web Service and private cloud toolkits such as Eucalyptus and OpenStack provide users with methods for managing VM instances via APIs, command‐line tools, web services, and so on. These are, however, not easy to use or customize for the average end users, especially for those in scientific research areas who just want to perform their work on a cloud and do not need to know the underlying technologies that much. Utilizing workflow management systems (WfMSs) in managing VMs on a cloud can alleviate these difficulties. Users only need to describe parameters needed for VMs and enact the workflow on a workflow enactment engine using user‐friendly interfaces. We propose a management scheme for VM instances on a cloud with the WfMS in this paper. We present a preliminary study on integrating cloud and WfMS focusing on management of VM instances and show an early implementation for a proof of concept with detailed explanations and possible usage scenarios. Copyright © 2015 John Wiley & Sons, Ltd.
Engineering Transition‐Metal‐Coated Tungsten Carbides for Efficient and Selective Electrochemical Reduction of CO2 to Methane
Authors: Wannakao Sippakorn , Artrith Nongnuch , Limtrakul Jumras , Kolpak Alexie M. 
Published: July 2015

AbstractThe design of catalysts for CO2 reduction is challenging because of the fundamental relationships between the binding energies of the reaction intermediates. Metal carbides have shown promise for transcending these relationships and enabling low‐cost alternatives. Herein, we show that directional bonding arising from the mixed covalent/metallic character plays a critical role in governing the surface chemistry. This behavior can be described by consideration of individual d‐band components. We use this model to predict efficient catalysts based on tungsten carbide with a sub‐monolayer of iron adatoms. Our approach can be used to predict site‐preference and binding‐energy trends for complex catalyst surfaces.
Upgrading Lignocellulosic Products to Drop‐In Biofuels via Dehydrogenative Cross‐Coupling and Hydrodeoxygenation Sequence
Authors: Sreekumar Sanil , Balakrishnan Madhesan , Goulas Konstantinos , Gunbas Gorkem , Gokhale Amit A. , Louie Lin , Grippo Adam , Scown Corinne D. , Bell Alexis T. , Toste F. Dean 
Published: July 2015

AbstractLife‐cycle analysis (LCA) allows the scientific community to identify the sources of greenhouse gas (GHG) emissions of novel routes to produce renewable fuels. Herein, we integrate LCA into our investigations of a new route to produce drop‐in diesel/jet fuel by combining furfural, obtained from the catalytic dehydration of lignocellulosic pentose sugars, with alcohols that can be derived from a variety of bio‐ or petroleum‐based feedstocks. As a key innovation, we developed recyclable transition‐metal‐free hydrotalcite catalysts to promote the dehydrogenative cross‐coupling reaction of furfural and alcohols to give high molecular weight adducts via a transfer hydrogenation–aldol condensation pathway. Subsequent hydrodeoxygenation of adducts over Pt/NbOPO4 yields alkanes. Implemented in a Brazilian sugarcane biorefinery such a process could result in a 53–79 % reduction in life‐cycle GHG emissions relative to conventional petroleum fuels and provide a sustainable source of low carbon diesel/jet fuel.
Tunable Blue–Red Emission and Energy‐Transfer Properties of Mg3(PO4)2:­Eu2+,­Mn2+ Phosphors
Authors: Zhang Zheng , Tang Wanjun 
Published: July 2015

AbstractA series of Eu2+‐doped and Eu2+/Mn2+‐codoped Mg3(PO4)2 phosphors were synthesized by the combustion‐assisted synthesis method. Under UV excitation, Mg3(PO4)2:Eu2+ presents a broad emission band, which can be decomposed into two symmetrical bands centered at λ = 427 and 467 nm, owing to the substitution of two kinds of Mg2+ sites by Eu2+ ions. In Mg3(PO4)2:Eu2+,Mn2+ phosphors, the excitation spectra monitored at the red emission of the Mn2+ ions is similar to that monitored at the blue emission of the Eu2+ ions, which illustrates the possibility of energy transfer from the Eu2+ ions to the Mn2+ ions. The variations of the emission spectra and decay lifetimes further demonstrate the existence of energy transfer from the Eu2+ ions to the Mn2+ ions under UV excitation. The energy‐transfer mechanism is dominated by electric dipole–dipole interactions, which can be validated by the agreement of the critical distances obtained from the concentration‐quenching (9.69 Å) and spectrum‐overlap methods (8.04 Å). The 4T1 → 6A1 emission band of the Mn2+ ions in Mg3(PO4)2:0.04Eu2+,yMn2+ shows a redshift as a function of the Mn2+ concentration (y), which has been discussed in relation to the exchange interactions between Mn2+–Mn2+ pairs.
Biomimetic Autocatalytic Synthesis of Organized Silica Hybrids
Authors: Licsandru Erol , Petit Eddy , Moldovan Simona , Ersen Ovidiu , Barboiu Mihail 
Published: July 2015

AbstractBiogenic formation of silica is a fundamental process occurring under mild conditions. Here we report autocatalytic generation of silica hybrid materials. Self‐organized siloxanes containing imidazole self‐catalytic groups can be transformed to hybrid silica by using mild biomimetic conditions similar to those under which primitive organisms make silica.
Epidemiology of painful procedures performed in neonates: A systematic review of observational studies
Authors: Cruz M.D. , Fernandes A.M. , Oliveira C.R. 
Published: July 2015

AbstractBackground and objectiveProcedural pain in neonates has been a concern in the last two decades. The purpose of this review was to provide a critical appraisal and a synthesis of the published epidemiological studies about procedural pain in neonates admitted to intensive care units. The aims were to determine the frequency of painful procedures and pain management interventions as well as to identify their predictors.Databases and data treatmentAcademic Search, CINAHL, LILACS, Medic Latina, MEDLINE and SciELO databases were searched for observational studies on procedural pain in neonates admitted to intensive care units. Studies in which neonatal data could not be extracted from the paediatric population were excluded.ResultsEighteen studies were included in the review. Six studies with the same study duration, the first 14 days of the neonate life or admission in the unit of care, identified 6832 to 42,413 invasive procedures, with an average of 7.5–17.3 per neonate per day. The most frequent procedures were heel lance, suctioning, venepuncture and insertion of peripheral venous catheter. Pharmacological and nonpharmacological approaches were inconsistently applied. Predictors of the frequency of procedures and analgesic use included the neonate's clinical condition, day of unit stay, type of procedure, parental presence and pain assessment. The existence of pain protocols was not a predictor of analgesia.ConclusionsPainful procedures were performed frequently and often with inadequate pain management. Unlike neonate clinical factors, organizational factors may be modified to promote a context of care more favourable to pain management.
Electrochemical Sensors Based on Molybdenum Disulfide Nanomaterials
Authors: Wang Tanyuan , Du Kuangzhou , Liu Wanglian , Zhang Jinxuan , Li Meixian 
Published: July 2015

AbstractNanostructured molybdenum disulfide (MoS2) has been arousing great research interest in many fields in recent years due to their peculiar properties. In this short review, we introduce recent advances in nanostructured MoS2 as potential materials for construction of electrochemical sensors. The potential application prospect of the electrochemical sensors based on MoS2 nanomaterials is proposed.
Influence of the Solvent on the “Casting” Methodology for MWCNT‐Modified Glassy Carbon and Platinum Electrodes
Authors: Dorim Ana Carolina Ângelo , Aleixo Herbert , de Souza Barcellos Edilton , Okumura Leonardo Luiz 
Published: July 2015

AbstractThe choice of electrode material and surface preparation method are usually dictated by the suitability of the electrode to observe an electrochemical parameter, such as heterogeneous electron transfer rate, surface coverage, or redox potential. Thus, the glassy carbon (GC) and platinum (Pt) electrodes were modified with multiwalled carbon nanotubes (MWCNT) by direct “casting” modification using nine different aliquots of solvents. After drying at room temperature, the modified electrode showed distinct redox peaks corresponding to ferrocyanide oxidation/reduction. Using chemometrics, the cyclic voltammograms with higher current intensity were obtained for those in which ethanol, water and acetone as dispersing agents were used for GCE and dimethylformamide, water and acetone for Pt electrode modification.
Study of a Novel Bisnaphthalimidopropyl Polyamine as Electroactive Material for Perchlorate‐selective Potentiometric Sensors
Authors: Gil Renato , Amorim Célia G. , Crombie Laura , Kong Thoo Lin Paul , Araújo Alberto , da Conceição Montenegro Maria 
Published: July 2015

AbstractIn this work, the new polyamine bisnaphthalimidopropyl‐4,4’‐diaminodiphenylmethane is proposed as a new ionophore for perchlorate potentiometric sensors. The optimal formulation for the membrane comprised of 12 mmol kg−1 of the ionophore, and 68 % (w/w) of 2‐nitrophenyl phenyl ether as plasticizer and 31 % (w/w) of high molecular weight PVC. The sensors were soaked in water for a week to allow leakage of anionic impurities and for one day in a perchlorate solution (10−4 mol L−1) to improve reproducibility due to its first usage. The stability constant for the ionophore‐perchlorate association in the membrane, log βIL1=3.18±0.04, ensured a performance characterized by the slope of 54.1 (±0.7) mV dec−1 to perchlorate solutions with concentrations between 1.24×10−7 and 1.00×10−3 mol L−1. The sensors are insensitive to pH between 3.5 to 11.0, they have a practical detection limit of 7.66 (±0.42) ×10−8 mol L−1 and a response time below 60 s for solutions with perchlorate concentrations above 5×10−6 mol L−1. The accuracy of the results was confirmed by the analysis of the contaminant in a certified reference water sample.
Electrochemical Biosensor for Organophosphate Pesticides and Huperzine‐A Detection Based on Pd Wormlike Nanochains/Graphitic Carbon Nitride Nanocomposites and Acetylcholinesterase
Authors: Wang Bingxin , Ye Cui , Zhong Xia , Chai Yaqin , Chen Shihong , Yuan Ruo 
Published: July 2015

AbstractA new electrochemical biosensor was developed for organophosphorus pesticides (OPs) and huperzine‐A (hupA) detection based on Pd wormlike nanochains/graphitic carbon nitride (Pd WLNCs/g‐C3N4) nanocomposites and acetylcholinesterase (AChE). The morphologies and components of the nanocomposites were analyzed by transmission electron microscopy (TEM) and X‐ray photoelectron spectroscopy (XPS). The Pd WLNCs/g‐C3N4 nanocomposites could effectively immobilize enzymes and promote the signal amplification. Under the optimum condition, the proposed biosensor displayed well performance. The linear response ranges for the determination of OPs and hupA were 1.00 nM to 14.96 µM and 3.89 nM to 20.80 µM, respectively. The corresponding detection limits were 0.33 nM and 1.30 nM (S/N=3). Meanwhile, the biosensor owned good reproducibility and stability, and could also be applied to analyze practical samples, which would be a new hopeful method for pesticide analysis.