bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Satisfied Consumers Do Not Return: Variety Seeking's Effect on Short‐ and Long‐Term Intentions
Authors: Sánchez‐García Isabel , Pieters Rik , Zeelenberg Marcel , Bigné Enrique 
Published: May 2014

ABSTRACTEven satisfied consumers frequently do not come back, which challenges loyalty theory and marketing practice. It is reasoned that variety‐seeking tendencies will significantly affect short‐term revisit intentions, whereas satisfaction and regret will mostly determine long‐term revisit intentions. Thus, the influence of satisfaction on loyalty is hypothesized to be critically dependent on the time perspective of the intentions, now or later, and variety seeking. A representative survey (N = 400) in eight Spanish cities supported these predictions. Multivariate moderated‐mediation analyses revealed that indeed the influence of satisfaction, regret, and variety seeking critically depends on the time perspective of the behavioral intentions.
Effect of methionine‐deficient and methionine‐supplemented diets on the hepatic one‐carbon and lipid metabolism in mice
Authors: Aissa Alexandre Ferro , Tryndyak Volodymyr , de Conti Aline , Melnyk Stepan , Gomes Tarsila Daysy Ursula Hermogenes , Bianchi Maria Lourdes Pires , James S. Jill , Beland Frederick A. , Antunes Lusania Maria Greggi , Pogribny Igor P. 
Published: May 2014

ScopeA compromised nutritional status in methyl‐group donors may provoke several molecular alterations triggering the development of nonalcoholic fatty liver disease (NAFLD) in humans and experimental animals. In this study, we investigated a role and the underlying molecular mechanisms of methionine metabolic pathway malfunctions in the pathogenesis of NAFLD.Methods and resultsWe fed female Swiss albino mice a control (methionine‐adequate) diet and two experimental (methionine‐deficient or methionine‐supplemented) diets for 10 weeks, and the levels of one‐carbon metabolites, expression of one‐carbon and lipid metabolism genes in the livers were evaluated. We demonstrate that both experimental diets increased hepatic levels of S‐adenosyl‐l‐homocysteine and homocysteine, altered expression of one‐carbon and lipid metabolism genes, and caused lipid accumulation, especially in mice fed the methionine‐deficient diet. Markers of oxidative and ER stress response were also elevated in the livers of mice fed either diet.ConclusionOur findings indicate that both dietary methionine deficiency and methionine supplementation can induce molecular abnormalities in the liver associated with the development of NAFLD, including deregulation in lipid and one‐carbon metabolic pathways, and induction of oxidative and ER stress. These pathophysiological events may ultimately lead to lipid accumulation in the livers, triggering the development of NAFLD.
Methylation levels of the SCD1 gene promoter and LINE‐1 repeat region are associated with weight change: An intervention study
Authors: Martín‐Núñez Gracia María , Cabrera‐Mulero Rebeca , Rubio‐Martín Elehazara , Rojo‐Martínez Gemma , Olveira Gabriel , Valdés Sergio , Soriguer Federico , Castaño Luis , Morcillo Sonsoles 
Published: May 2014

ScopeEpigenetic processes may be affected by environmental factors. DNA methylation measured in LINE‐1 elements (LINE‐1, long interspersed nucleotide element‐1) correlates with LINE‐1 DNA methylation. Variations in stearoyl CoA desaturase (SCD) activity (a key enzyme in the fatty acid metabolism) may be involved in various processes that can lead to diseases such as obesity. We evaluated whether changes in diet after a nutritional intervention would be associated with changes in LINE‐1 DNA methylation and/or specific methylation of SCD1 gene promoter.Methods and resultsDesign: Prospective cohort intervention study with a control group. We recorded phenotypic, anthropometric, biochemical, and nutritional information at baseline and 1 year later. DNA methylation was quantified by pyrosequencing. LINE‐1 DNA methylation and SCD1 gene promoter methylation levels were similar at the beginning of the study in both populations, whereas after a year these levels were higher in the control group (p < 0.001). In the intervention group, those subjects who lost weight showed higher levels of SCD1 gene promoter methylation after the intervention. Subjects with lower adherence to a Mediterranean diet experienced larger changes in LINE‐1 methylation.ConclusionDNA methylation levels were associated with weight change and with adherence to a Mediterranean diet.
Congenital heart disease in monochorionic twins with and without twin‐to‐twin transfusion syndrome
Authors: Springer Stephanie , Mlczoch Elisabeth , Krampl‐Bettelheim Elisabeth , Mailáth‐Pokorny Mariella , Ulm Barbara , Worda Christof , Worda Katharina 
Published: May 2014

ABSTRACTObjectiveThis study aims to evaluate the prevalence of congenital heart disease (CHD) in monochorionic (MC) twin pregnancies with and without twin‐to‐twin transfusion syndrome (TTTS) in an unselected cohort, which underwent prenatal and postnatal echocardiography.MethodThis was a retrospective cohort study including 451 MC twin pregnancies between 2002 and 2012. Complete outcome data were available for 381 pregnancies. All patients had prenatal echocardiography, and postnatal echocardiography was performed in all newborns with symptoms or to follow‐up on prenatal findings. Data from prenatal and postnatal echocardiography and autopsy were analyzed. The classification of Houyel et al. was used for structural CHD.ResultsStructural CHD was diagnosed in 5.5% of all MC twins (42/762). Twins with TTTS showed a significant higher rate of CHD than unaffected twins (9.3% vs 4.7%; p = 0.03). Prenatal detection rate of CHD was 48%. Most common abnormalities were ventricular septal defects (VSD) (2.1%) followed by anomalies of the ventricular outflow tracts (1.3%) in the overall population and VSD (2.9%) and anomalies of the great arteries (2.9%) in the group with TTTS.ConclusionMC twin pregnancies show a high prevalence of structural CHD (5.5%), especially those affected by TTTS. A detailed prenatal and postnatal echocardiography could be considered in these pregnancies. © 2014 John Wiley & Sons, Ltd.
Upregulation of probing‐ and feeding‐related behavioural frequencies in Bemisia tabaci upon acquisition of Tomato yellow leaf curl virus
Authors: Jahan SM Hemayet , Lee Gwan‐Seok , Lee Sukchan , Lee Kyeong‐Yeoll 
Published: May 2014

AbstractBACKGROUNDThe behaviour of insect vectors can be altered by the acquisition of plant viruses. Bemisia tabaci, which is the vector of Tomato yellow leaf curl virus (TYLCV), causes damage to susceptible tomato cultivars. Here, the frequencies of several behavioural characteristics related to probing and feeding that are exhibited by non‐viruliferous (NV) and TYLCV‐viruliferous (V) adult B. tabaci were compared using a sandwich‐type parafilm cage.RESULTSThe frequencies of behaviours such as wing flapping, leg movement, body shaking and body position change while settling and feeding on plant leaves were higher in V than in NV whiteflies. Evaluation of probing frequencies by measuring the number and size of holes punctured in parafilm by whiteflies revealed that most holes had a diameter of 7.5–26.7 µm, which is within the range of proboscis diameters of whiteflies. There were more small‐sized holes than medium‐ and large‐sized holes. Male whiteflies produced more small‐sized holes, but females more mid‐sized holes. V whiteflies showed increased hole numbers but decreased feeding duration relative to NV whiteflies.CONCLUSIONAdult B. tabaci showed higher frequencies of probing and feeding behaviours when infected with TYLCV. These manipulations of feeding behaviours of insect vectors may result in increased transmission of plant virus. © 2014 Society of Chemical Industry
Consistent quasi‐shallow models of the global atmosphere in non‐spherical geopotential coordinates with complete Coriolis force
Authors: Staniforth Andrew 
Published: May 2014

A pair of dynamically consistent quasi‐shallow equation sets has recently been developed for global spherical atmospheres and oceans in spherical polar coordinates, using the standard spherical geopotential approximation. This pair is of intermediate complexity between two standard known pairs (one shallow, one deep). A surprising feature of this new pair is that the fluid is assumed to be of essentially shallow depth, yet the Coriolis force is completely represented. This is in contradistinction to the traditional shallow pair, where the Coriolis force is incompletely represented in order to achieve dynamical consistency.However, the Earth is better represented by a spheroid than by a sphere. It is shown herein that the aforementioned work can be generalised by making the weaker spheroidal geopotential approximation to obtain an analogous pair of quasi‐shallow equation sets using axisymmetric curvilinear orthogonal coordinates. This pair is derived in two different, but complementary, ways: via the traditional Eulerian approach, and via Hamilton's principle of least action.
Successful induction of labor: prediction by preinduction cervical length, angle of progression and cervical elastography
Authors: Pereira S. , Frick A. P. , Poon L. C. , Zamprakou A. , Nicolaides K. H. 
Published: May 2014

ABSTRACTObjectiveTo examine the potential value of preinduction cervical length, cervical elastography and angle of progression (AOP) in prediction of successful vaginal delivery and induction‐to‐delivery interval.MethodsThis was a prospective study in 99 women with singleton pregnancy undergoing preinduction ultrasound assessment at 35–42 weeks' gestation. Cervical length, elastographic score at the internal os and AOP were determined. Regression analysis was used to assess the relationship between cervical length and both AOP and elastographic score. Logistic regression analysis was used to determine which of the maternal characteristics (cervical length, AOP, elastographic score) were significant predictors of vaginal delivery and induction‐to‐delivery interval.ResultsVaginal delivery occurred in 66 (66.7%) cases and Cesarean delivery was performed in 33 (33.3%) cases. There were significant correlations between cervical length and both AOP (r = − 0.319) and elastographic score (r = 0.368). Significant independent prediction of vaginal delivery and induction‐to‐delivery interval was provided by nulliparity and cervical length, with no additional significant contribution from electrographic score or AOP.ConclusionsIn women undergoing induction of labor, AOP and elastographic score at the internal os are unlikely to be useful in prediction of vaginal delivery and induction‐to‐delivery interval. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.
Variable geometry wind turbine for performance enhancement, improved survivability and reduced cost of energy
Authors: Whitehouse Glen R. , Sibilia Marc J. , Bilanin Alan J. , Veers Paul 
Published: May 2014

AbstractThe conceptual design and proof‐of‐concept testing of a furling vertical axis wind turbine, suited to large‐scale offshore deployment, is described. Through the implementation of variable geometry capabilities, extreme storm loads can be reduced, and unsteady flow‐related fatigue loads can be minimized thereby reducing capital (structural) and maintenance costs. Moreover, annual power generation can be optimized in real‐time to account for unsteady wind effects related to weather and siting thus improving efficiency and annual power generation. Copyright © 2014 John Wiley & Sons, Ltd.
Development of a Novel Nomogram to Predict Hypertension Cure After Laparoscopic Adrenalectomy in Patients With Primary Aldosteronism
Authors: Utsumi Takanobu , Kamiya Naoto , Endo Takumi , Yano Masashi , Kamijima Shuichi , Kawamura Koji , Imamoto Takashi , Naya Yukio , Ichikawa Tomohiko , Suzuki Hiroyoshi 
Published: May 2014

AbstractBackgroundPrimary aldosteronism is the most common curable cause of secondary hypertension. Despite resection, however, many patients with primary aldosteronism continue to require antihypertensive drugs to control their blood pressure. Although many patients with primary aldosteronism want to know the postoperative probability of hypertension cure before surgery, there are no predictive models calculating its probability. We therefore developed a nomogram to predict hypertension cure in patients with primary aldosteronism after laparoscopic adrenalectomy.MethodsWe retrospectively surveyed 132 Japanese patients with primary aldosteronism who were treated by unilateral laparoscopic adrenalectomy. Hypertension cure was defined as normal blood pressure (<140/90 mmHg) without antihypertensive drugs 6 months postoperatively. We developed a novel nomogram that postoperatively predicted cured hypertension in 105 (80 %) randomly selected patients and validated it with the remaining 27 (20 %).ResultsAt 6 months, blood pressure had normalized in 42 % of patients without antihypertensive drugs. Duration of hypertension, preoperative number of antihypertensive drug classes, age, and sex were incorporated into a novel nomogram as independent predictors of hypertension cure. The value of the area under the receiver operating characteristics curve for this nomogram was 0.83—which was significantly higher than that of the Aldosteronoma Resolution Score—on internal validation.ConclusionsWe developed the first nomogram that can accurately predict postoperative hypertension cure in patients with primary aldosteronism. This nomogram can help clinicians calculate the probability of postoperative hypertension cure in patients with primary aldosteronism and objectively inform them of their hypertension outcome before laparoscopic adrenalectomy.
Organ Shortage: The Greatest Challenge Facing Transplant Medicine
Authors: Shafran David , Kodish Eric , Tzakis Andreas 
Published: May 2014

AbstractThe success of organ transplantation as a treatment for end‐stage organ disease has yielded a series of ethical quandaries originating from the issue of organ shortage. Scarcity of organs for transplantation necessitates formulation of just and fair allocation policies as well as ethically viable solutions to bridging the vast gap between organ supply and demand. The concept of “triage” provides a useful paradigm in which to contextualize the organ shortage issue. This entails subjugating the welfare of the individual patient for the benefit of the wider community as an ethically justified response to the challenge of scarcity.
Statistical and regulatory considerations in assessments of interchangeability of biological drug products
Authors: Tóthfalusi Lászlo , Endrényi László , Chow Shein-Chung 
Published: May 2014

AbstractWhen the patent of a brand-name, marketed drug expires, new, generic products are usually offered. Small-molecule generic and originator drug products are expected to be chemically identical. Their pharmaceutical similarity can be typically assessed by simple regulatory criteria such as the expectation that the 90 % confidence interval for the ratio of geometric means of some pharmacokinetic parameters be between 0.80 and 1.25. When such criteria are satisfied, the drug products are generally considered to exhibit therapeutic equivalence. They are then usually interchanged freely within individual patients. Biological drugs are complex proteins, for instance, because of their large size, intricate structure, sensitivity to environmental conditions, difficult manufacturing procedures, and the possibility of immunogenicity. Generic and brand-name biologic products can be expected to show only similarity but not identity in their various features and clinical effects. Consequently, the determination of biosimilarity is also a complicated process which involves assessment of the totality of the evidence for the close similarity of the two products. Moreover, even when biosimilarity has been established, it may not be assumed that the two biosimilar products can be automatically substituted by pharmacists. This generally requires additional, careful considerations. Without declaring interchangeability, a new product could be prescribed, i.e. it is prescribable. However, two products can be automatically substituted only if they are interchangeable. Interchangeability is a statistical term and it means that products can be used in any order in the same patient without considering the treatment history. The concepts of interchangeability and prescribability have been widely discussed in the past but only in relation to small molecule generics. In this paper we apply these concepts to biosimilars and we discuss: definitions of prescribability and interchangeability and their statistical implementation; the relation between bioequivalence and interchangeability for small-molecule drug products; regulatory requirements and expectations of biosimilar products in various jurisdictions; possible statistical approaches to establish the similarity and interchangeability of biologic drug products; definition of other technical terms such as switchability and automatic substitution. The paper will be concluded with a discussion of the anticipated future use of interchangeability of biological drug products.
Navigating Middle Grades: Role of Social Contexts in Middle Grade School Climate
Authors: Kim Ha Yeon , Schwartz Kate , Cappella Elise , Seidman Edward 
Published: May 2014

AbstractDuring early adolescence, most public school students undergo school transitions, and many students experience declines in academic performance and social‐emotional well‐being. Theories and empirical research have highlighted the importance of supportive school environments in promoting positive youth development during this period of transition. Despite this, little is known about the proximal social and developmental contexts of the range of middle grade public schools US students attend. Using a cross‐sectional dataset from the eighth grade wave of the Early Childhood Longitudinal Study—Kindergarten Cohort 1998–1999, the current study examines the middle grade school social context from the perspectives of administrators and teachers in public schools with typical grade configurations (k–8 schools, middle schools, and junior high schools) and how it relates to students’ perceptions of school climate. We find that administrators and teachers in k–8 schools perceive a more positive school social context, controlling for school structural and demographic characteristics. This school social context, in turn, is associated with students’ perceptions of their schools’ social and academic climate. Implications for educational policy and practice are discussed.
Morphometric Analysis of the Effect of Scapula Stabilization on Obstetric Brachial Plexus Paralysis Patients
Authors: Terzis Julia K. , Karypidis Dimitrios , Mendoza Ricardo , Kokkalis Zinon T. , Diawara Norou 
Published: May 2014

Background Scapular position and size deficiency is evident in obstetric brachial plexus paralysis (OBPP) patients due to the absence of balanced muscular forces acting on the scapula. Scapula stabilization (SS) procedures aim to restore a balanced musculature and anatomic position and to augment shoulder function and enhance developmental potential. Methods Retrospective chart review of 106 patients with OBPP between March 1979 and March 2007 was performed. Forty-one female and 27 male were included in the study. In 38 patients, the paralysis was global, 13 had Erb's paralysis with C7 root involvement; in 18 patients, the lesion was limited to C5 and C6. X-rays were evaluated, and scapula dimensions were manually measured at several stages. Shoulder abduction (SA) and external rotation (SER) outcomes were also recorded. Results Mean improvement was 85.68° in shoulder abduction and 36.74° in shoulder external rotation. SA and SER improvement was significantly better in those who underwent SS procedures compared to those who did not (mean improvement was increased by 9.15° and 8.54°, respectively). Improvement was noted in all scapular dimensions, in all groups, postoperatively. However, the mean improvement in scapular height, big width, small width, and oblique axis discrepancies was 4.92, 14.04, 12.66, and 13.89 %, respectively, higher in patients who underwent SS procedures compared to those who did not. Conclusion Dimensional discrepancies and functional outcomes are improved by SS procedures. Maximal results are attained in patients who have undergone both primary and secondary shoulder reconstruction before age 2.
Understanding the relationship between actual:ideal discrepancies and depressive symptoms: A developmental examination
Authors: Stevens Erin N. , Lovejoy M. Christine , Pittman Laura D. 
Published: May 2014

ABSTRACTSelf‐discrepancy theory (SDT) is one framework for understanding how goal failure is associated with depressive symptoms. The present studies sought to examine the variance in depressive symptoms explained by actual:ideal discrepancies, beyond what is accounted for by actual‐self ratings. Additionally, gender and grade were examined as potential moderators in the relationship. In Study 1 (N = 228), discrepancies accounted for additional variance in the level of depressive symptoms beyond what was explained by actual‐self ratings in a college sample. In Study 2 (N = 192), while similar global patterns were found, gender and grade differences emerged. For boys, the relationship between actual:ideal discrepancies and depressive symptoms was due to actual‐self ratings. For girls, a developmental pattern suggested that actual:ideal discrepancies become more important to the prediction of depressive symptoms among older girls. Implications for the emergence of the discrepancy–depression association are discussed.
Management of electrical storm: The mechanism matters
Authors: Maruyama Mitsunori 
Published: May 2014

AbstractAn electrical storm is a life‐threatening syndrome that is characterized by clustering of recurrent episodes of ventricular tachycardia (VT) or ventricular fibrillation (VF) within a relatively short period of time. Electrical storms occur in a wide variety of conditions, and successful treatment depends on a correct understanding of the mechanism underlying the recurrent arrhythmias. Management of electrical storms is challenging, but classifying patients according to the type of recurrent arrhythmia (monomorphic VT or polymorphic VT/VF) and the presence or absence of structural heart disease would aid differential diagnosis and allow for more specific therapies.