bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Catalytic Chemical Amide Synthesis at Room Temperature: One More Step Toward Peptide Synthesis.
Authors: Mohy El Dine Tharwat , Erb William , Berhault Yohann , Rouden Jacques , Blanchet Jerome 
Published: August 2015

AbstractA direct amide bond synthesis between carbocyclic acids and amines is achieved in the presence of a highly active bench‐stable catalyst.
ChemInform Abstract: The Synthesis of Cyclopropyl Amines and Cyclopropanols by the Reaction of Enamines and Trimethylsilyl Enol Ethers with CH2I2 and Et3Al.
Authors: Kadikova R. N. , Ramazanov I. R. , Zosim T. P. , Yaroslavova A. V. , Dzhemilev U. M. 
Published: August 2015

AbstractThe method offers access to 1‐substituted cyclopropanols and syn‐1,2‐disubstituted cyclopropyl amines.
ChemInform Abstract: Gold‐Catalyzed Rearrangement of Alkynyl Donor—Acceptor Cyclopropanes to Construct Highly Functionalized Alkylidenecyclopentenes.
Authors: Chen Huiyu , Zhang Jing , Wang David Zhigang 
Published: August 2015

AbstractThe synthetically robust entry is based on a 1,7‐addition/cyclization/elimination cascade reaction under mild conditions.
ChemInform Abstract: Heck, Suzuki and Sonogashira Cross‐Coupling Reactions Using ppm Level of SBA‐16 Supported Pd‐Complex.
Authors: Sarkar Shaheen M. , Rahman Md. Lutfor , Yusoff Mashitah Mohd 
Published: August 2015

AbstractThe catalyst is recoverable and reusable for five cycles without significant loss of activity.
ChemInform Abstract: Insight into O2‐Promoted Base‐Catalyzed N‐Alkylation of Amines with Alcohols.
Authors: Wang Chao , Chen Changpeng , Han Jian , Zhang Jingyu , Yao Yingming , Zhao Yingsheng 
Published: August 2015

AbstractA highly efficient and practical transition‐metal‐free CsOH/O2 catalyst system is developed for the N‐alkylation of amines with alcohols.
ChemInform Abstract: An Umpolung Strategy for the Synthesis of β‐Aminoketones via Copper‐Catalyzed Electrophilic Amination of Cyclopropanols.
Authors: Ye Zhishi , Dai Mingji 
Published: August 2015

AbstractA novel Cu‐catalyzed electrophilic ring‐opening amination of cyclopropanols with N,N‐dialkyl‐O‐benzoylhydroxylamines is studied to give β‐aminoketones in good to excellent yields.
ChemInform Abstract: Copper‐Catalyzed Regio‐ and Stereoselective Hydroallylation of Thioalkynes with Allylboronates: A Facile and Convenient Synthesis of 1,4‐Dienes.
Authors: Kong Wei , Che Chao , Kong Lichun , Zhu Gangguo 
Published: August 2015

AbstractThe hydroallylation reaction affords 1,4‐dienyl sulfides in moderate to good yield.
ChemInform Abstract: Metal‐Free Iodine‐Mediated Synthesis of Vinyl Sulfones at Room Temperature Using Water as Solvent.
Authors: Zhang Ning , Yang Daoshan , Wei Wei , Yuan Li , Cao Youjuan , Wang Hua 
Published: August 2015

AbstractA green synthesis of vinyl sulfones is performed by sulfonylation of styrenes with sodium arylsulfinates.
ChemInform Abstract: Cobalt(II) Catalyzed C(sp)—H Bond Functionalization of Alkynes with Phenyl Hydrazines: Facile Access to Diaryl 1,2‐Diketones.
Authors: Bharate Jaideep B. , Abbat Sheenu , Sharma Rohit , Bharatam Prasad V. , Vishwakarma Ram A. , Bharate Sandip B. 
Published: August 2015

AbstractThe formation of 1,2‐diketones succeeds upon the reaction between aryl hydrazines and aryl alkynes, but fails using aliphatic alkynes.
ChemInform Abstract: Microreactor Mediated Deoxygenation of Benzylic Alcohols in a Biphasic Organic‐Aqueous Medium.
Authors: Seo Seung Woo , Song Hyun Seung , Song Ju Ha , Kim Geon‐Hee , In Insik , Park Chan Pil 
Published: August 2015

AbstractA droplet‐based microreactor, which induces rapid mixing of HI and H3PO4 in the aqueous phase and alcohols in the organic phase is employed for the deoxygenation of various benzylic alcohols.
ChemInform Abstract: Transition‐Metal‐Free Benzannulation for Diverse and Polyfunctionalized Biaryl Formation.
Authors: Poudel Tej Narayan , Lee Yong Rok 
Published: August 2015

AbstractThe novel and efficient cascade reaction is based on the reaction between readily available β‐ketoesters, β‐ketoamides, or 1,3‐diketones with α,β‐unsaturated aldehydes or aryl aldehydes.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Addition of Arylboronic Acids to Nitrostyrenes.
Authors: He Qun , Xie Fang , Fu Guanghong , Quan Mao , Shen Chaoren , Yang Guoqiang , Gridnev Ilya D. , Zhang Wanbin 
Published: August 2015

AbstractThe scalable reaction between aryl boronic acids and aryl nitroalkenes proceeds with high yields and enantioselectivities, but fails using alkyl nitroalkenes.
ChemInform Abstract: Iron‐Catalyzed Oxidative C—H/C—H Cross‐Coupling Between Electron‐Rich Arenes and Alkenes.
Authors: Ma Yiyang , Zhang Dongchao , Yan Zhiyuan , Wang Mengfan , Bian Changliang , Gao Xinlong , Bunel Emilio E. , Lei Aiwen 
Published: August 2015

AbstractA novel FeCl3‐catalyzed oxidative cross‐coupling of 1,3,5‐trimethoxybenzene as electron‐rich arene with 1,1,‐diarylethenes as well as styrenes using DDQ as the oxidant is developed.
ChemInform Abstract: Asymmetric Synthesis of Dihydronaphthoquinones Containing Adjacent Stereocenters via a Sulfa‐Michael Addition Triggered Ring‐Expansion Approach.
Authors: Hu Zhi‐Peng , Zhuang Zhe , Liao Wei‐Wei 
Published: August 2015

AbstractA novel asymmetric synthetic approach for the construction of enantioenriched functionalized dihydroquinones incorporating adjacent quaternary and tertiary stereocenters is reported.
ChemInform Abstract: Organocatalytic Diastereoselective Synthesis of Chiral Decalines Through the Domino Claisen—Schmidt/Henry Reaction.
Authors: Shashank Adluri B. , Ramachary Dhevalapally B. 
Published: August 2015

AbstractStarting from cyclic enones and chiral 3‐aryl substituted 4‐nitrobutanals decaline systems with three contiguous stereocenters are prepared in often good yields and with very high enantioselectivities.
ChemInform Abstract: A Short, General, Suzuki—Miyaura Coupling Anchored Approach to 3‐Alkenylbutenolides: Total Synthesis of Akolactones A & B, Hamabiwalactone B and Ancepsenolide.
Authors: Vasamsetty Laxmaiah , Khan Faiz Ahmed , Mehta Goverdhan 
Published: August 2015

AbstractThe efficient and versatile synthesis allows for the preparation of compounds bearing one or two 3‐substituted butenolide moieties.
ChemInform Abstract: Selective Synthesis of 6′‐Arylidene‐1‐aryl‐3‐aryl‐spiro[pyrrolizidine‐2,2′‐cyclohexanone] by Cycloaddition of Azomethine Ylides to Dibenzylidene Cyclohexanone.
Authors: Gayen Biswajit , Banerji Avijit 
Published: August 2015

AbstractAzomethine ylides, generated in situ from L‐proline and aryl aldehydes, undergo cycloaddition reaction to form spiro compounds of type (IV).
ChemInform Abstract: Biocatalytic One‐Pot Three‐Component Synthesis of 3,3′‐Disubstituted Oxindoles and Spirooxindole Pyrans Using α‐Amylase from Hog Pancreas.
Authors: He Tao , Zeng Qing‐Qing , Yang Da‐Cheng , He Yan‐Hong , Guan Zhi 
Published: August 2015

AbstractThe title compounds are obtained by Knoevenagel/Michael reaction or Knoevenagel/Michael/cyclization reaction between isatins, malononitrile, and active methyl or active methylene compounds (acetone, nitromethane, indole, acetylacetone, 4‐hydroxycoumarin, and dimedone) under mild reaction conditions.
ChemInform Abstract: Metal‐Free Cascade Cyclization of Alkenes Toward Perfluorinated Oxindoles.
Authors: Tang Shi , Li Zhi‐Hao , Wang Ming‐Wei , Li Zhi‐Ping , Sheng Rui‐Long 
Published: August 2015

AbstractStarting from N‐arylacrylamides and perfluoroalkyl iodides variously substituted perfluorinated oxindoles are synthesized in high yields.
ChemInform Abstract: Lewis Acid Catalyzed C‐3 Alkylidenecyclopentenylation of Indoles: An Easy Access to Functionalized Indoles and Bisindoles.
Authors: Sarath Chand S. , Sasidhar B. S. , Prakash Praveen , Sasikumar P. , Preethanuj P. , Jaroschik Florian , Harakat Dominique , Vasse Jean‐Luc , Radhakrishnan K. V. 
Published: August 2015

AbstractThe title compounds are efficiently obtained in one‐pot by ring opening of pentafulvene derived diazabicyclic olefins.
ChemInform Abstract: Oxidant‐Free Rhodium(I)‐Catalyzed Difunctionalization of Acrylamide: An Efficient Approach to Synthesize Oxindoles.
Authors: Li Chen‐Chen , Yang Shang‐Dong 
Published: August 2015

AbstractArylacrylamides (I), (IV), and (VI) are found to react with aryl bromides and benzyl chloride in the presence of a Rh‐catalyst to yield oxindoles.
ChemInform Abstract: Direct Synthesis of Imidazolidin‐4‐ones via Cycloadditions of Imines with a Leuchs′ Anyhdride.
Authors: Sucu Bilgesu Onur , Ocal Nuket , Erden Ihsan 
Published: August 2015

AbstractA new method for a one‐step synthesis of imidazolidin‐4‐ones is developed based on tandem nucleophilic additions‐decarboxylation‐intramolecular cyclizations of imines with a Leuchs′ anhydride.
ChemInform Abstract: MgCl2·6H2O Catalyzed Highly Efficient Synthesis of 2‐Substituted‐1H‐benzimidazoles.
Authors: Ghosh Pranab , Subba Raju 
Published: August 2015

AbstractA new facile protocol is reported for the condensation of 1,2‐phenylenediamine with aryl‐ and hetaryl aldehydes to produce benzimidazoles.
ChemInform Abstract: Access to 2‐(Het)aryl and 2‐Styryl Benzoxazoles via Palladium‐Catalyzed Aminocarbonylation of Aryl and Vinyl Bromides.
Authors: Neumann Karoline T. , Lindhardt Anders T. , Bang‐Andersen Benny , Skrydstrup Troels 
Published: August 2015

AbstractThe efficient one‐pot protocol has a broad substrate scope and is suitable for 13C labeling of the oxazole ring.
ChemInform Abstract: Catalytic Asymmetric Inverse‐Electron‐Demand Oxa‐Diels—Alder Reaction of in situ Generated ortho‐Quinone Methides with 3‐Methyl‐2‐vinylindoles.
Authors: Zhao Jia‐Jia , Sun Si‐Bing , He Sai‐Huan , Wu Qiong , Shi Feng 
Published: August 2015

AbstractThe first examples of an asymmetric inverse‐electron demand oxa‐Diels—Alder reaction of ortho‐quinone methides, generated in situ from ortho‐hydroxybenzyl alcohols, is described using 3‐methyl‐2‐vinylindoles as dienophiles.
ChemInform Abstract: Calcium‐Catalyzed Formal [2 + 2 + 2] Cycloaddition.
Authors: Meyer Vera J. , Ascheberg Christoph , Niggemann Meike 
Published: August 2015

AbstractA formal [2 + 2 + 2] cycloaddition of enynes (I) and (IV) with aliphatic and aromatic aldehydes is achieved in the presence of Ca(NTf2)2 and Bu4NPF6 or Bu4NBF4 as mixed catalyst system resulting in the formation of dihydropyran derivatives (III) and (V).
ChemInform Abstract: 2H‐Chromenes Generated by an Iron(III) Complex‐Catalyzed Allylic Cyclization.
Authors: Calmus L. , Corbu A. , Cossy J. 
Published: August 2015

AbstractA wide variety of 2H‐chromenes is prepared via FeCl3‐catalyzed allylic cyclization under microwave irradiation.
ChemInform Abstract: Zn‐Catalyzed Enantio‐ and Diastereoselective Formal [4 + 2] Cycloaddition Involving Two Electron‐Deficient Partners: Asymmetric Synthesis of Piperidines from 1‐Azadienes and Nitro‐Alkenes.
Authors: Chu John C. K. , Dalton Derek M. , Rovis Tomislav 
Published: August 2015

AbstractThe novel bisoxazoline diphenylamine ligand (OXA) provides high reactivity and enantioselectivity in the title process, which is proposed to proceed in a stepwise manner via Michael‐type addition of the imine to the nitroalkane followed by cyclization.
ChemInform Abstract: Unexpected Synthesis of 5,6‐Dihydropyridin‐2(1H)‐ones by a Domino Ugi/Aldol/Hydrolysis Reaction Starting from Baylis—Hillman Phosphonium Salts.
Authors: Zeng Xiao‐Hua , Wang Hong‐Mei , Ding Ming‐Wu 
Published: August 2015

AbstractThe one‐pot title reaction starts from aryl substituted Baylis‐Hillman phosphonium salts, arylglyoxylates, alkyl cyanides, and primary alkyl amines and does not tolerate aryl amines.
ChemInform Abstract: Unexpected Regiospecific Michael Addition Product: Synthesis of 5,6‐Dihydrobenzo[1,7]phenanthrolines.
Authors: Roopan Selvaraj Mohana , Bharathi Annadurai , Palaniraja Jeyakannu , Anand K. , Gengan R. M. 
Published: August 2015

AbstractReaction of benzylidenedihydroacridinones (I) with malononitrile using montmorillonite KSF as catalyst leads to the regiospecific formation of expected phenanthroline‐3‐carbonitriles (V) whilst the use of NaH as base results in the regiospecific formation of unexpected Michael addition products (IV).
ChemInform Abstract: Synthesis of Unprecedented Benzofused [1,2,4]‐Triazoloquinazolines via Benzyne Diels—Alder Reaction with 7‐Vinyl‐[1,2,4]triazolo[1,5‐c]pyrimidines as Dienes.
Authors: Wang Chao , Tang Caifei , Fang Xiangdong , Li Zhiming , Wang Quanrui 
Published: August 2015

AbstractThe oxidative aromatization of the dehydroaromatization products to complex heterocyclic ring systems is exemplified.
ChemInform Abstract: Mn Doped ZrO2 as a Green, Efficient and Reusable Heterogeneous Catalyst for the Multicomponent Synthesis of Pyrano[2,3‐d]‐pyrimidine Derivatives.
Authors: Maddila Surya Narayana , Maddila Suresh , van Zyl Werner E. , Jonnalagadda Sreekantha B. 
Published: August 2015

AbstractThe title pyrimidines (IV) are efficiently obtained by condensation reaction between dimethylbarbituric acid, various aromatic aldehydes and malononitrile under mild and environmentally friendly reaction conditions.
ChemInform Abstract: Alkylation of Nitrogen‐Containing Heterocycles via in situ Sulfonyl Transfer.
Authors: Panteleev Jane , Maguire Robert J. , Kung Daniel W. 
Published: August 2015

AbstractA range of sulfonyl substituted N‐heterocycles are submitted to a convenient desulfonylative alkylation procedure using a variety of primary and secondary alcohols as the alkylating agents.
ChemInform Abstract: I2‐Promoted Denitration Strategy: One‐Pot Three Component Synthesis of Pyrrole‐Fused Benzoxazines.
Authors: Sagar A. , Babu Venkata Nagarjuna , Dey Arnab , Sharada Duddu S. 
Published: August 2015

AbstractCoupling of 2‐aminophenols with acetylenic ester (II) affords alkylidene benzoxazine intermediates.
ChemInform Abstract: Synthesis Toward CRHR1 Antagonists Through 2,7‐Dimethylpyrazolo[1,5‐α][1,3,5]triazin‐4(3H)‐one C—H Arylation.
Authors: Long Jinghai , Lee Woong‐Sup , Chough Chieyeon , Bae Il Hak , Kim B. Moon 
Published: August 2015

AbstractAryl iodides as reactants give mostly lower yields.
ChemInform Abstract: Sequential Friedel—Crafts‐Type α‐Amidoalkylation/Intramolecular Hydroarylation: Distinct Advantage of Combined Tf2NH/Cationic LAu(I) as a Consecutive or Binary Bicatalytic System.
Authors: Boiaryna Liliana , Azizi Mohamed Salah , El Bouakher Abderrahman , Picard Baptiste , Taillier Catherine , Othman Mohamed , Trabelsi‐Ayadi Malika , Dalla Vincent 
Published: August 2015

AbstractThe process gives polycyclic heterocycles generally as separable mixtures of 6‐exo‐dig and 7‐endo‐dig cyclization products.
ChemInform Abstract: Nickel Complexes of 1,2,4‐Triazole Derived Amido‐Functionalized N‐Heterocyclic Carbene Ligands: Synthesis, Theoretical Studies and Catalytic Application.
Authors: Kumar Anuj , Bheeter Linus Paulin , Gangwar Manoj Kumar , Sortais Jean‐Baptiste , Darcel Christophe , Ghosh Prasenjit 
Published: August 2015

AbstractThe new catalysts show only low to moderate activity in the borylation reaction of aryl bromides (I) with bis(pinacolato)diboron (II).
ChemInform Abstract: Synthesis of Benzofused 1,4‐Azaborinols via [4 + 2] Annulation Strategy and Its Application in Indole Synthesis.
Authors: Chinnapattu Murugan , Sathiyanarayanan Kulathu Iyer , Iyer Pravin S. 
Published: August 2015

AbstractThe first general synthesis of benzo‐fused 1,4‐azaborinols and their smooth conversion into corresponding indoles are reported.
ChemInform Abstract: Copper‐Catalyzed Silylative Allylation of Ketones and Aldehydes Employing Allenes and Silylboranes.
Authors: Tani Yosuke , Yamaguchi Tatsuya , Fujihara Tetsuaki , Terao Jun , Tsuji Yasushi 
Published: August 2015

AbstractThe copper‐catalyzed silylative allylation of ketones with allenes and silylboranes via an in situ generated β‐silylallylcopper intermediate is presented.
ChemInform Abstract: Cesium‐Catalyzed Regioselective Synthesis of Trisubstituted Heteroatom Alkenes: A New Strategy for the Preparation of Functional Alkenes.
Authors: Chen Jinyang , Tang Zhi , Qiu Renhua , He Yunhua , Wang Xie , Li Ningbo , Yi Haibo , Au Chak‐Tong , Yin Shuang‐Feng , Xu Xinhua 
Published: August 2015

AbstractA regio‐, chemo‐, and (Z)‐stereoselective synthesis of vinylic dichalcogenides is developed using the CsOH‐catalyzed three‐component coupling of terminal alkynes, diaryl disulfides, and diaryl diselenides or tellurides.
ChemInform Abstract: Synthesis of Unsymmetrical Diorganyl Chalcogenides under Greener Conditions: Use of an Iodine/DMSO System, Solvent‐ and Metal‐Free Approach.
Authors: Saba Sumbal , Rafique Jamal , Braga Antonio L. 
Published: August 2015

AbstractThe use of iodine as the catalyst and DMSO as the oxidant renders possible the coupling of diorganyl dichalcogenides with arylboronic acids and vinyltrifluoroborate (VIII) to give the title products in good yields.
ChemInform Abstract: New Triterpenoid Glycosides from the Roots of Camellia oleifera Abel.
Authors: Li Xia , Zhao Jianping , Li Xiaoran , Liu Yanli , Xu Qiongming , Khan Ikhlas A. , Yang Shilin 
Published: August 2015

AbstractThe five new triterpenoid saponins oleiferoside I (Ia), J (Ib), K (Ic), L (IIa), and M (IIb) are isolated from the roots of Camellia oleifera Abel.
ChemInform Abstract: Microwave and Ultrasound Assisted First Synthesis of 12‐Hydroxyhentriacontane.
Authors: Kaur Jasamrit , Kaur Irvinder , Jindal Gitanjali , Manhas Priya , Gupta Neeru , Singh Jasvinder 
Published: August 2015

AbstractFor the first time, title compound (I), naturally occurring in the leaves of Ziziphus mauritiana, is efficiently synthesized using microwave or ultrasound irradiation, respectively.
ChemInform Abstract: PTP1B Inhibitors from Stems of Angelica keiskei (Ashitaba).
Authors: Li Jin‐long , Gao Li‐xin , Meng Fan‐wang , Tang Chun‐lan , Zhang Ru‐jun , Li Jing‐ya , Luo Cheng , Li Jia , Zhao Wei‐min 
Published: August 2015

AbstractThe three new chalcones, xanthoangelol K (I), L (II), and M (III) are isolated from the stems of Angelica keiskei along with 19 known compounds.
ChemInform Abstract: Cytochalasin Derivatives from a Jellyfish‐Derived Fungus Phoma sp.
Authors: Kim Eun La , Wang Haibo , Park Ju Hee , Hong Jongki , Choi Jae Sue , Im Dong Soon , Chung Hae Young , Jung Jee H. 
Published: August 2015

AbstractFour new cytochalasin derivatives (I), (II), (III), and (IV) are isolated from the jellyfish‐derived fungus Phoma sp.
ChemInform Abstract: Synthetic Studies on Natural Products. Part 83. Stereoselective Total Synthesis of Crassalactone A, a Natural Cytotoxic Styryl Lactone.
Authors: Reddy Parigi Raghavendar , Das Biswanath 
Published: August 2015

AbstractA stereoselective total synthesis of crassalactone A (I), a naturally occurring cytotoxic styryl lactone, is described.
ChemInform Abstract: Electrolytic Manganese Dioxide (EMD): A Perspective on Worldwide Production, Reserves and Its Role in Electrochemistry
Authors: Biswal Avijit , Chandra Tripathy Bankim , Sanjay Kali , Subbaiah Tondepu , Minakshi Manickam 
Published: August 2015

AbstractReview: 215 refs.
ChemInform Abstract: Crown‐Substituted Phthalocyanines‐Components of Molecular Ionoelectronic Materials and Devices
Authors: Martynov A. G. , Gorbunova Yu. G. , Tsivadze A. Yu. 
Published: August 2015

AbstractReview: synthetic approaches towards oxa‐crown‐substituted phthalocyanines including vrious metal complexes of s‐, p‐, d‐, and f‐elements and their coordination, supr amolecular and materials chemistry; 184 refs.
ChemInform Abstract: Characterization of the Interaction Between Heme and a Parallel G‐Quadruplex DNA Formed from d(TTAGGGT)
Authors: Shimizu Haruna , Tai Hulin , Saito Kaori , Shibata Tomokazu , Kinoshita Masashi , Yamamoto Yasuhiko 
Published: August 2015

AbstractReview: 42 refs.
Population‐based study of the effect of gene expression profiling on adjuvant chemotherapy use in breast cancer patients under the age of 65 years
Authors: Potosky Arnold L. , O'Neill Suzanne C. , Isaacs Claudine , Tsai Huei‐Ting , Chao Calvin , Liu Chunfu , Ekezue Bola F. , Selvam Nandini , Kessler Larry G. , Zhou Yingjun , Schwartz Marc D. 
Published: August 2015

BACKGROUNDGene expression profiling (GEP) testing can help to predict the risk of cancer recurrence and guide decisions about adjuvant chemotherapy for breast cancer (BC). However, no prior US studies have evaluated the relation between GEP testing and the use of adjuvant chemotherapy by women treated in a general oncology practice.METHODSEligible patients were women under the age 65 of years who were newly diagnosed with their first stage I or II, hormone receptor–positive BC between 2006 and 2011 (n = 9405). This retrospective study was conducted with a data set consisting of registry data, health claims data, and GEP testing results. The distribution of GEP test results was reported in terms of the risk of recurrence predicted, and logistic regression was used to assess the association of test results with chemotherapy use, with adjustments made for multiple patient characteristics.RESULTSThe proportions of tested women with low, intermediate, and high recurrence score results were 51%, 39%, and 10%, respectively. Among these women, 11%, 47%, and 88%, respectively, received adjuvant chemotherapy. There was a significant, positive linear relation of assay scores with chemotherapy use within the low and intermediate subgroups after adjustments for all other factors (adjusted odds ratios, 1.17 and 1.20, respectively).CONCLUSIONSAdjuvant chemotherapy use after GEP testing is generally consistent with the recommended test interpretation for women with a high or low predicted risk of recurrence. Chemotherapy use in the intermediate‐risk group increased with Recurrence Score values, and evidence from ongoing randomized trials may help to clarify whether this finding reflects optimal interpretation of GEP test results. These results demonstrate the principle that genomic testing, on the basis of research establishing its utility, can be applied appropriately in general practice in accordance with guideline recommendations. Cancer 2015;121:4062–4070. © 2015 American Cancer Society.
Proton Migration in Clusters Consisting of Protonated Pyridine Solvated by Water Molecules
Authors: Berthias Francis , Feketeová Linda , Chermette Henry , Forquet Valérian , Morell Christophe , Abdoul‐Carime Hassan , Farizon Bernadette , Farizon Michel , Märk Tilmann D. 
Published: August 2015

AbstractProton transfer (PT) from protonated pyridine to water molecules is observed after excitation of microhydrated protonated pyridine (Py) clusters PyH+(H2O)n (n=0–5) is induced by a single collision with an Ar atom at high incident velocity (95×103 m s−1). Besides the fragmentation channel associated with the evaporation of water molecules, the charged‐fragment mass spectrum shows competition between the production of the PyH+ ion (or its corresponding charged fragments) and the production of H+(H2O) or H+(H2O)2 ions. The increase in the production of protonated water fragments as a function of the number of H2O molecules in the parent cluster ion as well sd the observation of a stable H+(H2O)2 fragment, even in the case of the dissociation of PyH+(H2O)2, are evidence of the crucial role of PT in the relaxation process, even for a small number of solvating water molecules.