bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual support and education for adults with mild intellectual disabilities: a Delphi study on multiple perspectives
Authors: de Wit W. , Frielink N. , Roeg D. , Embregts P. J. C. M. 
Published: July 2024

AbstractBackgroundProviding appropriate sexual support and education for adults with mild intellectual disabilities (IDs) is a source of considerable debate, resulting in diverse, non‐funded and potentially adverse practices. This study aims to identify a consensus among experts regarding what conditions are conducive to successful sexual support and education for adults with mild IDs.MethodsA Delphi study was conducted with 13 experts, including experts‐by‐experience, relatives, support staff, psychologists and sexologists. Qualitative data on the conditions for sexual support and education were gathered in the first round and thematically analysed. In the following three quantitative rounds, consensus was achieved using Likert‐type response scales and participants' feedback.ResultsRound 1 resulted in 82 conditions on six themes: ‘the necessary attitude’, ‘requirements’, ‘approach to delivering sexual support and education’, ‘appropriate providers’, ‘settings and timing’ and ‘effective collaboration with the network’. In the following three quantitative rounds, the experts reached consensus on 68 conditions distributed across the six themes.ConclusionsThe six themes highlight conducive conditions for successful sexual support and education for adults with mild IDs, emphasising the significance of a safe and supportive environment, comprehensive educational programmes, and the promotion of autonomy and protection. The consensus‐based findings have distinct implications for practice and future research.
Exploring the triad: VPS35, neurogenesis, and neurodegenerative diseases
Authors: Qiu Zixiong , Deng Xu , Fu Yuan , Jiang Mei , Cui Xiaojun 
Published: July 2024

AbstractVacuolar protein sorting 35 (VPS35), a critical component of the retromer complex, plays a pivotal role in the pathogenesis of neurodegenerative diseases (NDs). It is involved in protein transmembrane sorting, facilitating the transport from endosomes to the trans‐Golgi network (TGN) and plasma membrane. Recent investigations have compellingly associated mutations in the VPS35 gene with neurodegenerative disorders such as Parkinson's and Alzheimer's disease. These genetic alterations are implicated in protein misfolding, disrupted autophagic processes, mitochondrial dysregulation, and synaptic impairment. Furthermore, VPS35 exerts a notable impact on neurogenesis by influencing neuronal functionality, protein conveyance, and synaptic performance. Dysregulation or mutation of VPS35 may escalate the progression of neurodegenerative conditions, underscoring its pivotal role in safeguarding neuronal integrity. This review comprehensively discusses the role of VPS35 and its functional impairments in NDs. Furthermore, we provide an overview of the impact of VPS35 on neurogenesis and further explore the intricate relationship between neurogenesis and NDs. These research advancements offer novel perspectives and valuable insights for identifying potential therapeutic targets in the treatment of NDs.image
Effectiveness of technology‐based psychosocial interventions for improving health‐related outcomes of family caregivers of stroke survivors: A systematic review and meta‐analysis
Authors: Hounsri Kanokwan , Zhang Jinghua , Kalampakorn Surintorn , Boonyamalik Plernpit , Jirapongsuwan Ann , Wu Vivien Xi , Klainin‐Yobas Piyanee 
Published: July 2024

AbstractAimTo synthesize evidence regarding the effectiveness of technology‐based psychosocial interventions in improving health‐related outcomes among family caregivers of stroke survivors.DesignA systematic review and meta‐analysis was reported by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines.MethodsRandomized controlled trials that investigated the effects of psychosocial interventions delivered through information and communication technologies on self‐efficacy, caregiving competence, caregiver burden, perceived social support, anxiety, depression, health‐related quality of life and cost‐effectiveness were included. Two researchers independently selected studies, extracted data, and appraised the quality of the included studies. Subgroup analysis, sensitivity analysis, and narrative synthesis were conducted.Data SourcesTen electronic databases (PubMed, CENTRAL, Web of Science, Scopus, CINHAL, Embase, Institution of Electrical Engineers Xplore, Ovid Medline, PsycINFO, ProQuest Dissertations and Thesis) were searched up to February 2023.ResultsNineteen studies involving 1717 participants fulfilled the eligibility criteria. Technology‐based psychosocial interventions significantly improved self‐efficacy (SMD = .62), caregiving competence (SMD = .55), depression (SMD = −.25) and anxiety (SMD = −.35). However, perceived social support, caregiver burden, and health‐related quality of life did not show significant improvements. Subgroup analyses revealed that the interventions, lasting from 4 to 6 weeks and encompassing comprehensive contents, exhibited larger effect sizes. None of the studies measured cost‐effectiveness.ConclusionThe technology‐based psychosocial interventions are effective in enhancing self‐efficacy and caregiving competence, as well as alleviating anxiety, and depression among family caregivers of stroke survivors. Future research should investigate interventions delivered through various digital platforms using well‐designed RCTs with in‐depth qualitative data collection and measurement of health and cost‐effectiveness outcomes.ImpactThrough psychosocial interventions, healthcare providers in clinical and community settings, particularly nurses, could incorporate technologies into current stroke care practices.Patient or Public ContributionIt is not applicable as this is a systematic review.RegistrationThe protocol was registered on PROSPERO (CRD42023402871).
Nurse led models of care for outpatient substance use disorder treatment: A scoping review
Authors: Abram Marissa D. , Marzano Maryta , Caniano Lori , Searby Adam 
Published: July 2024

AbstractAimTo map key characteristics and describe nurse led models of care for the treatment of persons with substance use disorders (SUDs) in the outpatient setting.DesignA scoping review.MethodsConducted in accordance with the JBI methodology. The PRISMA‐ScR checklist was used.Data SourcesPubmed, CINAHL Complete (EBSCOhost), Cochrane Library, APA PsycNet and Scopus were searched from 1999 to May 2022 and updated on 28 November 2023. A handsearch and a grey literature search was conducted.ResultsTitle and abstract screening was performed on 774 articles resulting in 88 articles for full text screening. Full text screening yielded 13 articles that met inclusion criteria.ConclusionExisting nurse‐led models of care for SUDS are scarce and limited in scope, with the majority focused on treating opioid use disorder. Additional research is needed to develop, test, and implement efficacious nurse‐led models of care for the treatment and management of SUDs.Implications to Clinical PracticeNurse led models of care have demonstrated their efficacy and quality in the management of other chronic diseases. As we move forward with innovative solutions for individuals with addiction, nurse led models of care can be a mechanism to deliver high quality, evidence‐based care for SUDs.ImpactSUDs are chronic diseases that impact individuals, families, and communities. SUDs require a biopsychosocial approach to treatment. Globally, nurses are well positioned to provide high quality care to mitigate the impact of SUDs. This scoping review mapped the extant literature on nurse led models of care for substance use disorder treatment in the outpatient setting finding that additional research is needed to develop, test and implement evidence‐based interventions to care for individuals, families, and communities experiencing SUDs.Reporting MethodPRISMA checklist for scoping reviews.No patient or public contribution were part of this study.Protocol RegistrationOpen Science Framework accessible at: https://doi.org/10.17605/OSF.IO/NSW7V.
All‐cause and cause‐specific mortality risk and loss in life expectancy associated with incident type 2 diabetes onset age and duration
Authors: Zhang Yin , Song Mingyang , Wang Molin , Hertzmark Ellen , Wu Kana , Eliassen A. Heather , Mucci Lorelei A. , Sun Qi , Stampfer Meir J. , Willett Walter C. , Hu Frank B. , Giovannucci Edward L. 
Published: July 2024

AbstractBackgroundEvidence on type 2 diabetes onset age and duration on mortality risk has been limited by short follow‐up, inadequate control for confounding, missing repeated measurements, and inability to cover the full range of onset age, duration, and major causes of death. Moreover, scarce data dissect how type 2 diabetes onset age and duration shape life expectancy.MethodsWe evaluate prospectively these topics based on 270,075 eligible participants in the Nurses’ Health Studies and Health Professionals Follow‐up Study, leveraging repeated measurements throughout up to 40 years of follow‐up. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsIn fully adjusted analyses, incident early onset type 2 diabetes (diagnosed <40 years of age) was associated with significantly higher mortality from all‐causes (HR, 95% CI was 3.16, 2.64–3.79; vs. individuals without type 2 diabetes), cardiovascular disease (6.56, 4.27–10.1), respiratory disease (3.43, 1.38–8.51), neurodegenerative disease (5.13, 2.09–12.6), and kidney disease (8.55, 1.98–36.9). The relative risk elevations declined dramatically with each higher decade of age at diagnosis for deaths from most of these causes, though the absolute risk difference increased continuously. A substantially higher cumulative incidence of mortality and a greater loss in life expectancy were associated with younger age at type 2 diabetes diagnosis. Longer disease duration was associated with generally higher relative and absolute risk of mortality.ConclusionEarly onset of type 2 diabetes and longer disease duration are associated with substantially increased risk of all‐cause and cause‐specific mortality and greater loss in life expectancy.
What has a year of social isolation due to the COVID‐19 pandemic influenced oral parafunctional habits and temporomandibular disorders? A case–control study
Authors: Leão Amanda Grossi , Lalue‐Sanches Monique , Hoyuela Carmen Paz Santibañez , Sanches Marcelo José , de Moraes Luis Otávio Carvalho 
Published: July 2024

AbstractObjectiveFew studies investigated the influence of oral parafunctional habits during the COVID‐19 pandemic. Since some studies have demonstrated that signs and symptoms of temporomandibular disorder (TMD), as well as psychological alterations, increased during the COVID‐19 pandemic lockdown, the aim of this study was to investigate whether social isolation is a situation that increases the prevalence of oral parafunctional habits.MethodsThis was an observational case–control study. An online survey with questions about TMD symptoms (Diagnostic Criteria Symptom Questionnaire) and oral parafunctional habits (Oral Behaviours Checklist [OBC]) was administered to Brazilian residents at two different times (2020 and 2021). The participants were divided according to social isolation practices into study groups (GI: 2020, n = 507; GIII: 2021, n = 282) and control groups (GII: 2020, n = 98; GIV: 2021, n = 202).ResultIn each group, we evaluated the association of the frequency of oral parafunctional habits with the symptoms of TMD, and we observed that individuals with a greater presence of painful TMD present a greater number of oral parafunctional habits. Despite the literature showing that individuals who practiced social isolation developed more oral parafunctional habits, when analysing the association of the OBC questions in Groups GI × GII and GIII × GIV, only ‘sustained talking’ (p = .0022) and ‘hold telephone between your hand and shoulders’ (p = .0124) showed a significant difference in GI × GII. Kendall's coefficient of concordance revealed that there was a very strong concordance (GI × GII 0.9515 (p = .0087) and GIII × GIV 0.9655 (p = .0074)) between the ranks of the analysed oral parafunctional habits in all groups.ConclusionWe can state that Individuals who practiced social isolation did not present more oral parafunctional habits than individuals who did not.
The impact of sweetness and saltiness preference on dietary diversity: Panel data analysis of households in South Korea
Authors: Kim Kyounghee , Eom Haram , Moon Junghoon 
Published: July 2024

AbstractThis study explores the relationship between consumers' taste preferences—specifically sweetness and saltiness—and dietary diversity. This study utilizes consumer panel data collected by the Rural Development Administration of South Korea, in combination with a food nutrient database. The study applies long‐term purchase data to derive indices of dietary diversity and taste preferences. The objective is to examine the impact of sweetness and saltiness preferences, as a consumer attitude, on dietary diversity as a consumption behavior. The findings suggest that consumer preference for sweet and salty tastes significantly contributes to dietary diversity, while preference for sweetness has a negative impact and preference for saltiness has a positive impact on dietary diversity.Practical ApplicationsThe utilization of long‐term consumer panel data for the calculation of household‐level dietary diversity, as an alternative to short‐term memory recall surveys, offers a more comprehensive and data‐driven approach to the measurement of dietary diversity. Furthermore, an integration of nutrient content with purchased items to quantify consumers' sweet and salty taste preferences and a measurement of preference based on nutrient intake can be employed as a more objective approach to assessing taste preferences.The results indicate that consumption behavior, specifically dietary diversity, is significantly influenced by sweet and salty taste preferences. Consumers who prefer sweetness are expected to exhibit lower dietary diversity, contributing to the association between sweetness preference and poorer health outcomes. In particular, as sweetness preference is a learned behavior, it is necessary to recognize that frequent exposure to sweetness fosters its preference and that this, in turn, negatively impacts dietary diversity. Therefore, individuals aiming for a higher level of dietary diversity should actively reduce their exposure to sweetness.
Higher‐order being and time
Authors: Skiba Lukas 
Published: July 2024

AbstractHigher‐order metaphysicians take facts to be higher‐order beings, i.e., entities in the range of irreducibly higher‐order quantifiers. In this paper, I investigate the impact of this conception of facts on the debate about the reality of tense. I identify two major repercussions. The first concerns the logical space of tense realism: on a higher‐order conception of facts, a prominent version of tense realism, dynamic absolutism, turns out to conflict with the laws of (higher‐order tense) logic. The second concerns our understanding of the positions occupying this logical space: on a higher‐order conception of facts, an attractive interpretation of the central tense realist notion of ‘facts constituting reality’ becomes unavailable. I discuss these results in the context of the more general project of higher‐order metaphysics and the (meta)metaphysics of time, drawing out their implications for the nature of the disputes both between realists and anti‐realists about tense and between different tense realist factions.
The marriage between stable isotope ecology and plant metabolomics – new perspectives for metabolic flux analysis and the interpretation of ecological archives
Authors: Gessler Arthur , Wieloch Thomas , Saurer Matthias , Lehmann Marco M. , Werner Roland A. , Kammerer Bernd 
Published: July 2024

SummaryEven though they share many thematical overlaps, plant metabolomics and stable isotope ecology have been rather separate fields mainly due to different mass spectrometry demands. New high‐resolution bioanalytical mass spectrometers are now not only offering high‐throughput metabolite identification but are also suitable for compound‐ and intramolecular position‐specific isotope analysis in the natural isotope abundance range. In plant metabolomics, label‐free metabolic pathway and metabolic flux analysis might become possible when applying this new technology. This is because changes in the commitment of substrates to particular metabolic pathways and the activation or deactivation of others alter enzyme‐specific isotope effects. This leads to differences in intramolecular and compound‐specific isotope compositions. In plant isotope ecology, position‐specific isotope analysis in plant archives informed by metabolic pathway analysis could be used to reconstruct and separate environmental impacts on complex metabolic processes. A technology‐driven linkage between the two disciplines could allow us to extract information on environment–metabolism interaction from plant archives such as tree rings but also within ecosystems. This would contribute to a holistic understanding of how plants react to environmental drivers, thus also providing helpful information on the trajectories of the vegetation under the conditions to come.
Genome‐wide Characterization of Small Secreted Peptides in Nicotiana tabacum and Functional Assessment of NtLTP25 in Plant Immunity
Authors: Li Han , Liu Yanxia , Gao Weichang , Zhu Jingwei , Zhang Heng , Wang Zhiyao , Liu Changying , Li Xiang 
Published: July 2024

AbstractSmall secreted peptides (SSPs), serving as signaling molecules for intercellular communication, play significant regulatory roles in plant growth, development, pathogen immunity, and responses to abiotic stress. Despite several SSPs, such as PIP, PSK, and PSY having been identified to participate in plant immunity, the majority of SSPs remain understudied, necessitating the exploration and identification of SSPs regulating plant immunity from vast genomic resources. Here we systematically characterized 756 putative SSPs across the genome of Nicotiana tabacum. 173 SSPs were further annotated as established SSPs, such as nsLTP, CAPE, and CEP. Furthermore, we detected the expression of 484 putative SSP genes in five tissues, with 83 SSPs displaying tissue‐specific expression. Transcriptomic analysis of tobacco roots under plant defense hormones revealed that 46 SSPs exhibited specific responsiveness to salicylic acid (SA), and such response was antagonistically regulated by methyl jasmonate. It's worth noting that among these 46 SSPs, 16 members belong to nsLTP family, and one of them, NtLTP25, was discovered to enhance tobacco's resistance against Phytophthora nicotianae. Overexpression of NtLTP25 in tobacco enhanced the expression of ICS1, subsequently stimulating the biosynthesis of SA and the expression of NPR1 and pathogenesis‐related genes. Concurrently, NtLTP25 overexpression activated genes associated with ROS scavenging, consequently mitigating the accumulation of ROS during the subsequent phases of pathogenesis. These discoveries indicate that these 46 SSPs, especially the 16 nsLTPs, might have a vital role in governing plant immunity that relies on SA signaling. This offers a valuable source for pinpointing SSPs involved in regulating plant immunity.
Extracellular vesicles in fresh frozen plasma and cryoprecipitate: Impact on in vitro endothelial cell viability
Authors: Hwang Ji Hui , Tung John‐Paul , Harkin Damien G. , Flower Robert L. , Pecheniuk Natalie M. 
Published: July 2024

AbstractBackgroundTransfusion‐related acute lung injury (TRALI) remains a major contributor to transfusion‐associated mortality. While the pathogenesis of TRALI remains unclear, there is evidence of a role for blood components. We therefore investigated the potential effects of fresh frozen plasma (FFP), cryoprecipitate, and extracellular vesicles (EVs) derived from these blood components, on the viability of human lung microvascular endothelial cells (HLMVECs) in vitro.MethodsEVs were isolated from FFP and cryoprecipitate using size‐exclusion chromatography and characterized by nanoparticle tracking analysis, western blotting, and transmission electron microscopy. The potential effects of these blood components and their EVs on HLMVEC viability (determined by trypan blue exclusion) were examined in the presence and absence of neutrophils, either with or without prior treatment of HLMVECs with LPS.ResultsEVs isolated from FFP and cryoprecipitate displayed morphological and biochemical properties conforming to latest international criteria. While FFP, cryoprecipitate, and EVs derived from FFP, each reduced HLMVEC viability, no effect was observed for EVs derived from cryoprecipitate.ConclusionOur findings demonstrate clear differences in the effects of FFP, cryoprecipitate, and their respective EVs on HLMVEC viability in vitro. Examination of the mechanisms underlying these differences may lead to an improved understanding of the factors that promote development of TRALI.
An Improved Wiener Path Integral Approach for Stochastic Response Estimation of Nonlinear Systems Under Non-White Excitation
Authors: Zhao Ying , Fan Fengyu 
Published: July 2024

Abstract
An improved Wiener path integral (WPI) approach is developed for predicting the stochastic response probability density functions (PDFs) of nonlinear systems under non-white excitation. Specifically, the excitation process is modeled as the output of a filter whose input is Gaussian white noise, the joint response PDF of the nonlinear system is expressed as a functional integral of the stochastic action over the space of all possible trajectories between the initial and final states, and the second-order variation of the stochastic action is recast to a quadratic form and taken into account in the estimation of the joint response PDF. Compared to the standard WPI approach where the second-order variation of the stochastic action is regarded as a constant, the improved WPI approach developed herein considers the fluctuations of the second-order variation of the stochastic action in the computational domain, thus improving the accuracy of the stochastic response estimation. Two numerical examples are illustrated, and the nonstationary response PDFs estimated by the improved WPI approach agree well with the Monte Carlo simulation results.
Off-Equilibrium Linearization-Based Control of Nonlinear Time-Delay System and Application to a Turbofan Engine
Authors: Yang Wenchong , Tang Yifeng , Zhou Wenxiang , Yang Gang , Huang Jinquan , Cui Tao 
Published: July 2024

Abstract
Turbofan engines exhibit pronounced nonlinearity due to component characteristics and thermal processes, necessitating linearization to connect engine control with linear control theory. Off-equilibrium linearization offers excellent transient tracking and controller performance, making it ideal for military turbofan engines with rapid acceleration and deceleration. Hardware-in-Loop (HIL) experiments are crucial for verifying controller performance, but time delays in the HIL platform can cause oscillations in state variables when using this linearization method. To address this issue, this paper introduces an off-equilibrium linearization-based control strategy. This strategy employs an off-equilibrium linearized model to approximate the nonlinear time-delay system, followed by designing an H∞ controller for the linear time-delay system. The effectiveness of this approach applied to turbofan engines, including its antidelay and robust tracking capabilities, is validated through simulations, HIL experiments, and semiphysical experiments.