bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concilier vie familiale et vie professionnelle en France : les disparités d’horaires de travail
Authors: Bustreel Anne , Cornuau Frédérique , Pernod-Lemattre Martine 
Published: December 2012

La France se caractérise aujourd’hui par une forte proportion de salariés ayant des contraintes familiales et par un nombre élevé d’entreprises qui flexibilisent la durée et les horaires de travail : comment la diffusion de ces nouvelles contraintes temporelles affectent-elles les femmes, et plus particulièrement les mères ? Une typologie des conditions temporelles d’emploi des salariés français intégrant la durée du travail, la souplesse horaire dont bénéficie le salarié et la « localisation » de son temps de travail, construite à partir de l’enquête « Familles et employeurs » (Ined-Insee, 2004-2005), fait apparaître une surreprésentation des femmes dans les emplois les plus souples, mais aussi les plus contraignants temporellement, alors que l’effet de la présence d’enfant semble assez mineur.Trois hypothèses sont testées pour expliquer les conditions temporelles d’emploi : la préférence des salariés pour des horaires de travail commodes, les caractéristiques productives des emplois et le rapport de force salarié-employeur. Les résultats montrent que le fait d’avoir de jeunes enfants n’est pas corrélé aux conditions temporelles d’emploi. Être une femme accroît la probabilité d’avoir des horaires hyper-souples (plutôt que standards contraints) et diminue la probabilité d’avoir des horaires longs souples et non standards contraints. L’hypothèse d’une sélection en fonction des préférences n’est pas confirmée par l’analyse alors que les exigences productives des emplois et des employeurs ainsi que le pouvoir de négociation des salariés exercent des effets significatifs et expliquent la surreprésentation des femmes dans les horaires fragmentés contraints.
Assessing ongoing sources of dissolved-phase polychlorinated biphenyls in a contaminated stream
Authors: Dang Viet D. , Walters David M. , Lee Cindy M. 
Published: December 2012

Abstract
Few studies assess the potential of ongoing sources of “fresh” polychlorinated biphenyls (PCBs) to aquatic systems when direct discharge to the environment has been eliminated. In the present study, the authors used single-layered, low-density polyethylene samplers (PEs) to measure total PCB concentrations, congener profiles, and enantiomeric fractions (EFs) in a contaminated stream and to provide multiple lines of evidence for assessing ongoing inputs of PCB. Concentrations were well above background levels that have been monitored for years. Concentrations significantly increased with distance, the farthest downstream PE concentrations being almost five times greater than those at 79 m downstream of a historical point source. The PCBs in the PEs at 79 m downstream of the contamination source were dominated by low KOW congeners, similar to those in the mixture of Aroclors 1016 and 1254 (4:1 v/v) historically released from the former capacitor manufacturer. The only two chiral congeners detected in the PEs downstream were PCBs 91 and 95. The EF values were nonracemic for PCB 91, while the values were either racemic or near racemic for PCB 95. Increased PCB concentrations with distance and a congener composition of predominantly low-weight congeners in the PEs at 79 m downstream of the plant site suggested an ongoing PCB source from the plant site. Chiral signatures suggested aerobic biotransformation of dissolved PCBs but did not shed any light on possible ongoing PCB inputs. Environ. Toxicol. Chem. 2013;32:535–540. © 2012 SETAC
High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury
Authors: Chen Minjun , Borlak Jürgen , Tong Weida 
Published: December 2012

Abstract

Drug-induced liver injury (DILI) is a leading cause of drug failure in clinical trials and a major reason for drug withdrawals from the market. Although there is evidence that dosages of ≥100 mg/day are associated with increased risk for hepatotoxicity, many drugs are safe at such dosages. There is an unmet need to predict risk for DILI more reliably, and lipophilicity might be a contributing factor. We analyzed the combined factors of daily dose and lipophilicity for 164 US Food and Drug Administration–approved oral medications and observed high risk for hepatotoxicity (odds ratio [OR], 14.05; P < 0.001) for drugs given at dosages ≥100 mg/day and octanol-water partition coefficient (logP) ≥3. This defined the “rule-of-two.” Similar results were obtained for an independent set of 179 oral medications with 85% of the rule-of-two positives being associated with hepatotoxicity (OR, 3.89; P < 0.01). Using the World Health Organization's Anatomical Therapeutic Chemical classification system, the rule-of-two performed best in predicting DILI in seven therapeutic categories. Among 15 rule-of-two positives, 14 were withdrawn from hepatotoxic drugs, and one was over-the-counter medication labeled for liver injury. We additionally examined drug pairs that have similar chemical structures and act on the same molecular target but differ in their potential for DILI. Again, the rule-of-two predicted hepatotoxicity reliably. Finally, the rule-of-two was applied to clinical case studies to identify hepatotoxic drugs in complex comedication regimes to further demonstrate its use. Conclusion: Apart from dose, lipophilicity contributes significantly to risk for hepatotoxicity. Applying the rule-of-two is an appropriate means of estimating risk for DILI compared with dose alone. (HEPATOLOGY 2013)
A Finite Element Study about CAM-Out Failure of the Recess-Screwdriver Interfaces for the Cold-Welded Periarticular Fixation
Authors: Chien C.-Y. , Chuang W.-H. , Tsai W.-C. , Lin S.-C. , Luh Y.-P. , Chen Y.-J. 
Published: December 2012

ABSTRACTIn clinical practice, cam-out failure at the recess-screwdriver interfaces may occur when tightening or removing a bone screw. For titanium-based periarticular fixation, the literature reports have revealed that cold welding at the plate-screw interfaces makes the screw recess especially prone to cam-out failure during screw removal. In this study, the effects of the four recess shapes (cross, hexagon, star, and crest), three torque value (0.8, 1.0, and 1.2N-m), and the three interfacial misfits (0.00, 0.05, and 0.10mm) on the cam-out failure were numerically evaluated. The free-rotation angle, torque-recess angle, slippage-resisting length, and interfacial stress distribution were defined and chosen as comparison indices for the twelve recess-misfit variations. The results revealed that the interfacial slippage, torque transfer, and stress distribution are highly related to both recess shape and interfacial misfit. The stresses of all recesses and screwdrivers consistently initiate at the contact sites. However, the recess profile significantly affects the stress propagation. The stress patterns of the recess and screwdriver are quite different between the cross-star and hexagon-crest groups. The cross-star group is superior to the hexagon-crest group in terms of the torque-recess angle and slippage-resisting length over. This makes the recess of the cross-star group less stressed than its counterpart. However, the volumes of the cross and the star screwdriver are more highly stressed than the hexagon due to the irregular shape and the thinner flange, respectively. The greater torque and misfit increase the performance difference between the four recess designs. In conclusion, the geometry of the cross and star groups provide the better performance of the screw recess in terms of torque-transferring efficiency and slippage-resisting ability. If the screwdriver material is properly strengthened and the stress-concentrating corners are modified, the cross and star groups would be the optimal designs that protects and extends the lifetime of both recess and reused screwdriver.
Improving Combustion Intensity and Modulating Flame Behaviors Using Helical-Grooved Cones
Authors: Yen S. C. , Shih C. L. 
Published: December 2012

AbstractFour helical-grooved cones were installed behind an unconfined combustion nozzle to increase the bluff-body effect and turbulence intensity (T.I.). The cone configurations included a smooth cone and the other three cones cut with 1, 2 and 3 helical v-grooves. Experimental results showed that the helical v-grooves transformed the axial momentum (or the axial velocity) to the angular momentum (or the angular velocity). TheT.I.was enhanced by increasing the tangential component of fuel-jet momentum. The direct photography and thermocouple were utilized to observe the flame structures and to delineate the characteristic flame modes, flame length, temperature distribution, and combustion intensity. The flame modes were classified as jet flame, flickering flame, bubble flame, recirculation flame, lifted flame and ring flame. The flame length decreases as the groove number increases. The increasedT.I.and groove number (or bluff-body effect) improve the fuel-air mixing. The total combustion intensity increases with annular-air jet and with the groove number.
The scaling of collisionless magnetic reconnection in an electron–positron plasma with non-scalar pressure
Authors: HOSSEINPOUR M. , MOHAMMADI M. A. , BIABANI S. 
Published: December 2012

AbstractCollisionless magnetic reconnection via tearing instability in non-relativistic electron–positron (pair) plasma with an anisotropic pressure is investigated. The equilibrium magnetic field is considered to be sheared force-free, and a set of linearized collisionless Magnetohydrodynamics equations describes the evolution of reconnection dynamics. A linear analytical analysis, based on scaling, demonstrates that in such a pair plasma, breaking the frozen in flow constraint for field lines can be mainly provided by the non-gyrotropic pressure of electrons and positrons (rather than the particle bulk inertia) when the current sheet width is smaller than the particle Larmor radius (Δx < rL). This condition is satisfied when β > d2 (d = c/ωp is the particle skin-depth with the electron/positron frequency ωp and β = 8πP(0)/B02 ⪡ 1). Meanwhile, on top of the Lorentz force and in the absence of the reconnection facilitating mechanism of the Hall effect, non-scalar pressure force can accelerate bulk plasma into the diffusion region at the scale lengths of the order of dx. Therefore, the respective regime of tearing instability proceeds much faster compared with the case of an isotropic pressure with a new dimensionless growth rate of (γτA) ~ d.
Australian interests, bifocalism, bipartisanship, and the Antarctic Treaty System
Authors: Haward Marcus , Cooper Nicholas 
Published: December 2012

ABSTRACTThis article explores the character of domestic political support for the Australian Antarctic Territory and Australia's involvement in the Antarctic Treaty System, using the linked frames of bifocalism and bipartisanship. After first unpacking these concepts it explores how they have shaped the extent and form of Australia's Antarctic endeavours from the 1930s to the present day. It is argued that the analysis shows that bipartisan commitment to Australian interests in Antarctica is framed through bifocalism: first, Australian national interests are closely linked to maintenance of the Antarctic Treaty and Antarctic Treaty System, and second, presentation of these national interests is not inimical to commitments to the Antarctic Treaty and Antarctic Treaty System.
Ultrashort-pulse MeV positron beam generation from intense Compton-scattering γ-ray source driven by laser wakefield acceleration
Authors: Luo W. , Zhuo H.B. , Ma Y.Y. , Yang X.H. , Zhao N. , Yu M.Y. 
Published: December 2012

AbstractIntense Compton-scattering γ-ray radiation driven by laser wakefield acceleration (LWFA) and generation of ultrashort positron beams are investigated by Monte Carlo simulation. Using an LWFA driven GeV electron bunch and a 45 femtosecond, 90 mJ/pulse, and 10 Hz Ti:Sapphire laser for driving the Compton scattering, fs γ-ray pulses were generated. The latter have a flux of ≥108/s, peak brightness of ≥1020 photons/(s mm2 mrad2 0.1% bandwidth), and photon energy of 5.9 to 23.2 MeV. The γ-ray pulses then impinge on a thin high-Z target. More than 107 positrons/s in the form of sub-100 fs pulses at several MeV can be produced. Such ultrashort positron pulses can be useful as the pump-probe type positron annihilation spectroscopy as well as in other applications.
Religion and Support for Democracy in Bosnia-Herzegovina
Authors: Valenta Marko , Strabac Zan 
Published: December 2012

AbstractThis article examines the relationship between religiosity and support for democracy in Bosnia-Herzegovina. Using data from the last World Values Survey, we examine levels of religiosity among Bosniaks, Serbs, and Croats, and their support for democracy. The influence of religiosity on support for democracy is also explored. The results indicate that religiosity has a negative influence on support for democracy, and it is particularly true for individuals who do not support the separation of the religious from the political sphere and who exhibit lower support for democracy. The article also examines different levels of religiosity among the three groups, controlling for a wide range of variables. We conclude that there is basically no difference in support for democracy between Croats and Bosniaks, while Serbs exhibit somewhat lesser support for democracy than members of the other two ethnic groups. Serbs also seem to be somewhat less religious than Bosniaks and Croats. Opposition to separation of the religious from the political sphere is a major source of lack of support for democracy among Croats and Bosniaks, but not among Serbs.
Microbial hitchhikers on intercontinental dust: catching a lift in Chad
Authors: Favet Jocelyne , Lapanje Ales , Giongo Adriana , Kennedy Suzanne , Aung Yin-Yin , Cattaneo Arlette , Davis-Richardson Austin G , Brown Christopher T , Kort Renate , Brumsack Hans-Jürgen , Schnetger Bernhard , Chappell Adrian , Kroijenga Jaap , Beck Andreas , Schwibbert Karin , Mohamed Ahmed H , Kirchner Timothy , de Quadros Patricia Dorr , Triplett Eric W , Broughton William J , Gorbushina Anna A 
Published: December 2012

AbstractAncient mariners knew that dust whipped up from deserts by strong winds travelled long distances, including over oceans. Satellite remote sensing revealed major dust sources across the Sahara. Indeed, the Bodélé Depression in the Republic of Chad has been called the dustiest place on earth. We analysed desert sand from various locations in Chad and dust that had blown to the Cape Verde Islands. High throughput sequencing techniques combined with classical microbiological methods showed that the samples contained a large variety of microbes well adapted to the harsh desert conditions. The most abundant bacterial groupings in four different phyla included: (a) Firmicutes—Bacillaceae, (b) Actinobacteria—Geodermatophilaceae, Nocardiodaceae and Solirubrobacteraceae, (c) Proteobacteria—Oxalobacteraceae, Rhizobiales and Sphingomonadaceae, and (d) Bacteroidetes—Cytophagaceae. Ascomycota was the overwhelmingly dominant fungal group followed by Basidiomycota and traces of Chytridiomycota, Microsporidia and Glomeromycota. Two freshwater algae (Trebouxiophyceae) were isolated. Most predominant taxa are widely distributed land inhabitants that are common in soil and on the surfaces of plants. Examples include Bradyrhizobium spp. that nodulate and fix nitrogen in Acacia species, the predominant trees of the Sahara as well as Herbaspirillum (Oxalobacteraceae), a group of chemoorganotrophic free-living soil inhabitants that fix nitrogen in association with Gramineae roots. Few pathogenic strains were found, suggesting that African dust is not a large threat to public health.
Water formation through O2 + D pathway on cold silicate and amorphous water ice surfaces of interstellar interest
Authors: Chaabouni H. , Minissale M. , Manicò G. , Congiu E. , Noble J. A. , Baouche S. , Accolla M. , Lemaire J. L. , Pirronello V. , Dulieu F. 
Published: December 2012

The formation of the first monolayer of water molecules on bare dust grains is of primary importance to understand the growth of the icy mantles that cover dust in the interstellar medium. In this work, we explore experimentally the formation of water molecules from O2 + D reaction on bare silicate surfaces that simulates the grains present in the diffuse interstellar clouds at visual extinctions (AV &lt; 3 mag). For comparison, we also study the formation of water molecules on surfaces covered with amorphous water ice representing the dense clouds (AV ⩾ 3 mag). Our studies focus on the formation of water molecules in the sub-monolayer and monolayer regimes using reflection absorption infrared spectroscopy and temperature-programmed desorption techniques. We provide the fractions of the products, such as D2O and D2O2 molecules formed on three astrophysically relevant surfaces held at 10 K (amorphous olivine-type silicate, porous amorphous water ice, and nonporous amorphous water ice). Our results showed that the formation of D2O molecules occurs with an efficiency of about 55%–60% on nonporous amorphous water ice and about 18% on bare silicate grains surfaces. We explain the low efficiency of D2O water formation on the silicate surfaces by the desorption upon formation of certain products once the reaction occurs between O2 and D atoms on the surface. A kinetic model taking into account the chemical desorption of newly formed water supports our conclusions.
Proximity and Investment: Evidence from Plant-Level Data
*
Authors: Giroud Xavier 
Published: December 2012

Abstract
Proximity to plants makes it easier for headquarters to monitor and acquire information about plants. In this article, I estimate the effects of headquarters’ proximity to plants on plant-level investment and productivity. Using the introduction of new airline routes as a source of exogenous variation in proximity, I find that new airline routes that reduce the travel time between headquarters and plants lead to an increase in plant-level investment of 8% to 9% and an increase in plants’ total factor productivity of 1.3% to 1.4%. The results are robust when I control for local and firm-level shocks that could potentially drive the introduction of new airline routes, when I consider only new airline routes that are the outcome of a merger between two airlines or the opening of a new hub, and when I consider only indirect flights where either the last leg of the flight (involving the plant’s home airport) or the first leg of the flight (involving headquarters’ home airport) remains unchanged. Moreover, the results are stronger in the earlier years of the sample period and for firms whose headquarters is more time-constrained. In addition, they also hold at the extensive margin, that is, when I consider plant openings and closures.
Identification of Anaerobic Bacteria by Bruker Biotyper Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry with On-Plate Formic Acid Preparation
Authors: Schmitt Bryan H. , Cunningham Scott A. , Dailey Aaron L. , Gustafson Daniel R. , Patel Robin 
Published: December 2012

ABSTRACT
Identification of anaerobic bacteria using phenotypic methods is often time-consuming; methods such as 16S rRNA gene sequencing are costly and may not be readily available. We evaluated 253 clinical isolates of anaerobic bacteria using the Bruker MALDI Biotyper (Bruker Daltonics, Billerica, MA) matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) system with a user-supplemented database and an on-plate formic acid-based preparation method and compared results to those of conventional identification using biochemical testing or 16S rRNA gene sequencing. A total of 179 (70.8%) and 232 (91.7%) isolates were correctly identified to the species and genus levels, respectively, using manufacturer-recommended score cutoffs. MALDI-TOF MS offers a rapid, inexpensive method for identification of anaerobic bacteria.
Serotype Analysis of Streptococcus pneumoniae in Lung and Nasopharyngeal Aspirates from Children in the Gambia by MassTag PCR
Authors: Tokarz Rafal , Briese Thomas , Morris Gerard , Ideh Readon , Chimah Osaretin , Ebruke Bernard , Desai Aaloki , Haq Saddef , Sameroff Stephen , Howie Stephen R. C. , Lipkin W. Ian 
Published: December 2012

ABSTRACT

Streptococcus pneumoniae
strains comprise >90 serotypes. Here we describe establishment of a MassTag PCR assay designed to serotype
S. pneumoniae
and demonstrate its utility in tests using 31 paired lung aspirate and nasopharyngeal aspirate samples from children with pneumonia in the Gambia. Serotypes 1, 5, and 14 in were implicated in 90% of lung infections. With 5 exceptions, serotypes found in lung aspirates were also found in nasopharyngeal aspirates.
Determination of Spontaneous Mutation Frequencies in Measles Virus under Nonselective Conditions
Authors: Zhang Xiaomeng , Rennick Linda J. , Duprex W. Paul , Rima Bert K. 
Published: December 2012

ABSTRACT

There is a paradox between the remarkable genetic stability of measles virus (MV) in the field and the high mutation rates implied by the frequency of the appearance of monoclonal antibody escape mutants generated when the virus is pressured to revert
in vitro
(S. J. Schrag, P. A. Rota, and W. J. Bellini, J. Virol. 73:51–54, 1999). We established a highly sensitive assay to determine frequencies of various categories of mutations in large populations of wild-type and laboratory-adapted MVs using recombinant viruses containing an additional transcription unit (ATU) encoding enhanced green fluorescent protein (EGFP). Single and double mutations were made in the fluorophore of EGFP to ablate fluorescence. The frequencies of reversion mutants in the population were determined by measuring the appearance of fluorescence indicating a revertant virus. This allows mutation rates to be measured under nonselective conditions, as phenotypic reversion to fluorescence requires only either a single- or a double-nucleotide change and amino acid substitution, which does not affect the length of the nonessential reporter protein expressed from the ATU. Mutation rates in MV are the same for wild-type and laboratory-adapted viruses, and they are an order of magnitude lower than the previous measurement assessed under selective conditions. The actual mutation rate for MV is approximately 1.8 × 10
−6
per base per replication event.