bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Microwave Mediated Solvent Free Synthesis of Formazans Catalyzed by Simple Ionic Liquids Derived from Dialkylammonium Salts.
Authors: Das Pranab Jyoti , Begum Jesmin 
Published: September 2015

AbstractDiethylammonium hydrogensulfate as an ionic liquid catalyst in the microwave‐assisted one‐pot three‐component reaction between arylamines (I), benzaldehydes (II) or (V) and phenylhydrazine (III) furnishes the formazans (IV) and (VI) in highs yield following a volatile‐organic‐compound‐ and solvent‐free green protocol.
ChemInform Abstract: Magnetic Nanoparticles Supported Oxime Palladacycle as a Highly Efficient and Separable Catalyst for Room Temperature Suzuki—Miyaura Coupling Reaction in Aqueous Media.
Authors: Gholinejad Mohammad , Razeghi Mehran , Najera Carmen 
Published: September 2015

AbstractA novel magnetic nanoparticle‐supported oxime palladacycle catalyst is successfully prepared and characterized.
ChemInform Abstract: Copper(I)‐Catalyzed Coupling Reaction of Aryl Boronic Acids with N,O‐Acetals and N,N‐Aminals under Atmosphere Leading to α‐Aryl Glycine Derivatives and Diarylmethylamine Derivatives.
Authors: Sakai Norio , Hori Hiroaki , Yoshida Yoshihiro , Konakahara Takeo , Ogiwara Yohei 
Published: September 2015

AbstractThe reaction tolerates cyclic and acyclic N,O‐acetals endowed with a coordinating ester, a coordinating aryl group or no substituent as well as N,N‐aminals.
ChemInform Abstract: Access to Spirocyclized Oxindoles and Indolenines via Palladium‐Catalyzed Cascade Reactions of Propargyl Carbonates with 2‐Oxotryptamines and Tryptamines.
Authors: Nibbs Antoinette E. , Montgomery Thomas D. , Zhu Ye , Rawal Viresh H. 
Published: September 2015

AbstractA variety of the desired N‐heterocyclic scaffolds, required for alkaloid preparation, is best available by reaction of the educts with propargyl carbonate (II).
ChemInform Abstract: Four‐Component Reaction Between Naphthols, Substituted β‐Nitrostyrenes, Substituted Benzaldehydes and Ammonium Acetate in Water—PEG‐400: An Approach to Construct Polysubstituted Naphthofuranamines.
Authors: Zhang Jungui , Yao Juan , Liu Jiaming , Xue Shuwen , Li Yang , Wang Cunde 
Published: September 2015

Abstractinvolving a sequence of Michael reaction, aza‐ene reaction, imine‐enamine/keto‐enol tautomerization, O‐cyclization and aromatization as key steps
ChemInform Abstract: Dienamine and Friedel—Crafts One‐Pot Synthesis, and Antitumor Evaluation of Diheteroarylalkanals.
Authors: Frias Maria , Padron Jose M. , Aleman Jose 
Published: September 2015

AbstractA two‐step, one‐pot procedure is developed to cyclize dialdehydes of type (I) in the presence of diphenylsilyl prolinol and subsequent condensation with indoles to give enantioenriched 2,3′‐connected diheteroarylalkanals with good enantioselectivities.
ChemInform Abstract: Direct Aromatic C—H Trifluoromethylation via an Electron‐Donor—Acceptor Complex.
Authors: Cheng Yuanzheng , Yuan Xiangai , Ma Jing , Yu Shouyun 
Published: September 2015

AbstractA simple method for the direct C—H trifluoromethylation of mainly indoles and pyrroles using Umomoto′s reagent under mild conditions is developed.
ChemInform Abstract: Palladium‐Catalyzed C—H Ethoxycarbonyldifluoromethylation of Electron‐Rich Heteroarenes.
Authors: Shao Changdong , Shi Guangfa , Zhang Yanghui , Pan Shulei , Guan Xiaohong 
Published: September 2015

AbstractA Pd‐catalyzed reaction of electron‐rich heteroarenes with ethyl bromodifluoroacetate is presented which allows the synthesis of a diverse range of ethoxycarbonyldifluoromethylated heteroarenes, generally in a highly regioselective manner.
ChemInform Abstract: Cobalt(II)/Silver Relay Catalytic Isocyanide Insertion/Cycloaddition Cascades: A New Access to Pyrrolo[2,3‐b]indoles.
Authors: Gao Qian , Zhou Peng , Liu Feng , Hao Wen‐Juan , Yao Changsheng , Jiang Bo , Tu Shu‐Jiang 
Published: September 2015

AbstractA novel Co/Ag bimetallic catalyzed bicycloaddition of arylethynylanilines (I) and (IV) with isonitriles is presented.
ChemInform Abstract: C(sp3)—C(sp3) Bond Cleavage in the Palladium‐Catalyzed Aminohydroxylation of Allylic Hydrazones Using Atmospheric Oxygen as the Sole Oxidant
Authors: Chen Yu‐Chen , Zhu Ming‐Kui , Loh Teck‐Peng 
Published: September 2015

Abstractaffording various substituted 1H‐pyrazoles
ChemInform Abstract: One‐Pot Synthesis of 5‐Alkoxy‐4‐amino‐3‐halo‐2(5H)‐furanones Containing Benzimidazole Moiety in the Absence of Metal Catalyst
Authors: Peng Pai , Feng Min‐Hua , Shi Jie , Zheng Jia‐Li , Wu Yan‐Cheng , Wang Zhao‐Yang , Chen Ren‐Hong 
Published: September 2015

Abstract21 examples
ChemInform Abstract: An Efficient and Confluent Approach for the Synthesis of Novel 3,4‐Dihydro‐2H‐naphtho[2,3‐e][1,3]oxazine‐5,10‐dione Derivatives by a Three Component Reaction in Ionic Liquid.
Authors: Khanna Garima , Aggarwal Komal , Khurana Jitender M. 
Published: September 2015

AbstractA three component reaction of 2‐hydroxy‐1,4‐naphthoquinone, anilines, and formaldehyde is developed in [bmim]BF4 as catalytic solvent to give the title compounds (IV) in excellent yields.
ChemInform Abstract: Palladium‐Catalyzed Desulfurative Sonogashira Cross‐Coupling Reaction of 3‐Cyano Assisted Thioamide‐Type Quinolone Derivatives with Alkynes
Authors: Wu You , Xing Yongning , Wang Jie , Sun Qi , Kong Weiqi , Suzenet Franck 
Published: September 2015

Abstractaffording alkynylated quinoline derivatives
ChemInform Abstract: Novel Synthesis of Isoquinoline Derivatives Derived from (Z)‐4‐(1,3‐Diphenylpyrazol‐4‐yl)isochromene‐1,3‐dione.
Authors: Mahmoud Mahmoud R. , El‐Shahawi Manal M. , Abou‐Elmagd Wael S. I. , Hekal Mohamed H. 
Published: September 2015

AbstractA series of novel isoquinoline derivatives are synthesized by reaction of the title isochromenedione (I) with hydrazides, amines, diamines, and 2‐aminothiophenol.
ChemInform Abstract: Stereoselective Synthesis of Chiral Polycyclic Indolic Architectures Through Pd0‐Catalyzed Tandem Deprotection/Cyclization of Tetrahydro‐β‐carbolines on Allenes.
Authors: Gobe Valerian , Guinchard Xavier 
Published: September 2015

AbstractEnantioenriched indole substrates, prepared by Pictet—Spengler reaction, undergo deprotection/cyclization reactions.
ChemInform Abstract: Cu(I)‐Catalyzed Synthesis of N‐Tosyl‐4‐iminoquinolizines.
Authors: Chen Joanna L. , Namirembe Sheila , Lauchert Luke T. , Tsougranis Gregory H. , Isaacs Andre K. 
Published: September 2015

AbstractKetenimines generated in situ from 2‐pyridyl compounds and azide (II) undergo an intramolecular cyclization reaction to yield iminoquinolizines.
ChemInform Abstract: Direct Amination of Pyrimidin‐2‐yl Tosylates with Aqueous Ammonia under Metal‐Free and Mild Conditions.
Authors: Gong Hai‐Peng , Zhang Yue , Da Yu‐Xia , Zhang Zhang , Quan Zheng‐Jun , Wang Xi‐Cun 
Published: September 2015

AbstractThe reaction is not sensitive to steric or electronic effects of the substituents.
ChemInform Abstract: Formation of Carbocycles via a 1,4‐Rh Shift Triggered by a Rhodium‐Catalyzed Addition of Terminal Alkynes to 3,3‐Diarylcyclopropenes.
Authors: Sawano Takahiro , Hashizume Minoru , Nishimoto Shouta , Ou Keiyu , Nishimura Takahiro 
Published: September 2015

AbstractThe title reaction provides silylated tricyclic addition products which can be further converted into naphthalene derivatives as shown in case of product (IIIb).
ChemInform Abstract: Antiinflammatory Sesquiterpenes from the Medicinal Herb Tanacetum sinaicum.
Authors: Hegazy Mohamed‐Elamir F. , Hamed Ahmed R. , Mohamed Tarik A. , Debbab Abdessamad , Nakamura Seikou , Matsuda Hisashi , Pare Paul W. 
Published: September 2015

AbstractFrom newly isolated sesquiterpenes (I), (II), and (III) only (I) shows intermediate inhibition of NO production in a mouse peritoneal macrophage system (IC50: 15.7 μM).
ChemInform Abstract: Two New Triterpene Saponins from Acanthophyllum laxiusculum
Authors: Pertuit David , Baghery Lotfabad Tayebe , Mitaine‐Offer Anne‐Claire , Miyamoto Tomofumi , Tanaka Chiaki , Lacaille‐Dubois Marie‐Aleth 
Published: September 2015

Abstractisolation and structure determination
ChemInform Abstract: Enantiomeric 3‐Arylcoumarins and 2‐Arylcoumarones from the Roots of Glycyrrhiza uralensis as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors.
Authors: Ji Shuai , Qiao Xue , Li Zi‐wei , Wang Yong‐rui , Yu Si‐wang , Liang Wen‐fei , Lin Xiong‐hao , Ye Min 
Published: September 2015

AbstractAll compounds show significant inhibitory activities against PTP1B.
ChemInform Abstract: Understanding the Chemistry Behind the Antioxidant Activities of Butylated Hydroxytoluene (BHT): A Review
Authors: Yehye Wageeh A. , Rahman Noorsaadah Abdul , Ariffin Azhar , Abd Hamid Sharifah Bee , Alhadi Abeer A. , Kadir Farkaad A. , Yaeghoobi Marzieh 
Published: September 2015

AbstractReview: 189 refs.
Selective early expression of the orphan nuclear receptor Nr4a2 identifies the claustrum homolog in the avian mesopallium: Impact on sauropsidian/mammalian pallium comparisons
Authors: Puelles L. , Ayad A. , Alonso A. , Sandoval J.E. , MartÍnez‐de‐la‐Torre M. , Medina L. , Ferran J.L. 
Published: September 2015

ABSTRACTThe transcription factor Nr4a2 was recently revealed as a very early developmental marker of the claustrum (CL) proper in the mouse. The earliest claustral primordium was identified superficially, dorsal to the olfactory cortex, and was subsequently covered by the Nr4a2‐negative cells of the insular cortex. Some tangentially migrating claustral derivatives (subplate cells and some endopiriform elements) also expressed this marker. The present study employs the same genetic marker to explore the presence of a comparable pallial division in chicken in which, in principle, the same pallial sectors exist as in mammals. We were indeed able to delineate an early‐developing Nr4a2‐positive mantle domain at the expected topologic position within the developing chicken lateral pallium. In the chicken as well as in the turtle (from data in the literature), the earliest postmitotic lateropallial cells likewise express Nr4a2 and occupy a corticoid superficial stratum of the mesopallium, which is clearly comparable in spatial and chronological profile to the mouse CL. Other cells produced in this pallial sector include various tangentially migrating Nr4a2‐labeled derivatives as well as Nr4a2‐negative and Nr4a2‐positive local deeper subpopulations that partially interdigitate, forming mesopallial core and shell populations. We hold that the deep avian and reptilian mesopallial formation developing under the superficial corticoid CL homolog represents a field homolog of the insula, although additional studies are required to underpin this hypothesis. J. Comp. Neurol. 524:665–703, 2016. © 2015 Wiley Periodicals, Inc.
Ultrastructure of geniculocortical synaptic connections in the tree shrew striate cortex
Authors: Familtsev Dmitry , Quiggins Ranida , P. Masterson Sean , Dang Wenhao , Slusarczyk Arkadiusz S. , Petry Heywood M. , Bickford Martha E. 
Published: September 2015

ABSTRACTTo determine whether thalamocortical synaptic circuits differ across cortical areas, we examined the ultrastructure of geniculocortical terminals in the tree shrew striate cortex to compare directly the characteristics of these terminals with those of pulvinocortical terminals (examined previously in the temporal cortex of the same species; Chomsung et al. [] Cereb Cortex 20:997–1011). Tree shrews are considered to represent a prototype of early prosimian primates but are unique in that sublaminae of striate cortex layer IV respond preferentially to light onset (IVa) or offset (IVb). We examined geniculocortical inputs to these two sublayers labeled by tracer or virus injections or an antibody against the type 2 vesicular glutamate antibody (vGLUT2). We found that layer IV geniculocortical terminals, as well as their postsynaptic targets, were significantly larger than pulvinocortical terminals and their postsynaptic targets. In addition, we found that 9–10% of geniculocortical terminals in each sublamina contacted GABAergic interneurons, whereas pulvinocortical terminals were not found to contact any interneurons. Moreover, we found that the majority of geniculocortical terminals in both IVa and IVb contained dendritic protrusions, whereas pulvinocortical terminals do not contain these structures. Finally, we found that synaptopodin, a protein uniquely associated with the spine apparatus, and telencephalin (TLCN, or intercellular adhesion molecule type 5), a protein associated with maturation of dendritic spines, are largely excluded from geniculocortical recipient layers of the striate cortex. Together our results suggest major differences in the synaptic organization of thalamocortical pathways in striate and extrastriate areas. J. Comp. Neurol. 524:1292–1306, 2016. © 2015 Wiley Periodicals, Inc.
Treating youth in pain: Comparing tailored behavioural medicine treatment provided by physical therapists in primary care with physical exercises
Authors: Holm S. , Ljungman G. , Åsenlöf P. , Linton S.J. , Söderlund A. 
Published: September 2015

AbstractObjectivesTo study the efficacy of tailored behavioural medicine treatment within a physical therapy framework.MethodsThe study was a randomized controlled study (RCT): tailored behavioural medicine treatment (EXT) delivered by physical therapists (PTs) was compared with exercise‐based treatment (CT). Thirty‐two adolescents (mean age 14.3 years) with persistent pain participated. Data on pain‐related disability and school attendance (primary outcomes), pain intensity, catastrophizing, fear of movement and self‐efficacy were collected.ResultsThe pain‐related disability measured by the Functional Disability Inventory (FDI) resulted in mean score change of EXT = −18 and CT = −11, respectively. A significant change within both groups was found (EXT p = 0.003, CT p = 0.001), and a large effect size for FDI between the conditions was demonstrated (AUC of 0.77). For school attendance post‐treatment, no difference was found between conditions. For secondary outcomes, a significant improvement in pain intensity and pain catastrophizing was found for the EXT and self‐efficacy for the CT groups but no statistically significant difference between the two conditions was detected. Caution should be given to the small sample size, as it may affect the interpretation and generalizability of the results.ConclusionIn this study, differences between tailored behavioural medicine treatment delivered by PTs and exercise‐based treatment could not be demonstrated, although the effect size was large. Patients who received either treatment demonstrated significant changes over time in pain‐related disability. The low number of participants and suboptimal tailoring of the psychological components may partly explain the failure to demonstrate differences between groups, and future studies are warranted.
Energy efficient relay networks with wireless power transfer from a multi‐antenna base station
Authors: Wang Xinhua , Liu Ju , Zhai Chao , Ma Shuang , Wang Qing 
Published: September 2015

AbstractIn this paper, we investigate the energy efficiency (EE) of a decode‐and‐forward relay network with wireless energy harvesting. The data transmission between a multi‐antenna base station (BS) and its user equipment is assisted by an intermediate relay node, which operates with the wireless energy harvesting. The BS firstly transmits energy and information to the relay node, which can harvest the energy and retract the information simultaneously using the power‐splitting or time‐switching method. Then, the relay node forwards its decoded information to the user equipment using all the harvested energy. Through maximising the instantaneous EE for the power‐splitting‐based system, the optimal power‐splitting ratio and the optimal transmit power of the BS are derived in closed form for each time block. To maximise the instantaneous EE for the time‐switching‐based system, an optimisation algorithm is proposed to judiciously determine the harvesting time and the transmit power of the BS for each time block. Furthermore, we optimise the number of antennas N of the BS by taking into account the circuit power consumption, as it cannot be ignored when N is large. Finally, simulation results are presented to validate our derived closed‐form solutions and verify the efficiency of our proposed algorithm. Copyright © 2015 John Wiley & Sons, Ltd.
The intersection marker method for 3D interface tracking of deformable surfaces in finite volumes
Authors: Ho Mark , Yeoh Guan , Reizes John , Timchenko Victoria 
Published: September 2015

SummaryCurrently, the majority of computational fluid dynamics (CFD) codes use the finite volume method to spatially discretise the computational domain, sometimes as an array of cubic control volumes. The Finite volume method works well with single‐phase flow simulations, but two‐phase flow simulations are more challenging because of the need to track the surface interface traversing and deforming within the 3D grid. Surface area and volume fraction details of each interface cell must be accurately accounted for, in order to calculate for the momentum exchange and rates of heat and mass transfer across the interface. To attain a higher accuracy in two‐phase flow CFD calculations, the intersection marker (ISM) method is developed. The ISM method is a hybrid Lagrangian–Eulerian front‐tracking algorithm that can model an arbitrary 3D surface within an array of cubic control volumes. The ISM method has a cell‐by‐cell remeshing capability that is volume conservative and is suitable for the tracking of complex interface deformation in transient two‐phase CFD simulations. Copyright © 2015 John Wiley & Sons, Ltd.
MiR‐199a/b‐3p suppresses migration and invasion of breast cancer cells by downregulating PAK4/MEK/ERK signaling pathway
Authors: Li Shou‐Qing , Wang Zi‐Hang , Mi Xu‐Guang , Liu Lei , Tan Yan 
Published: September 2015

AbstractMicroRNA‐199a/b‐3p is downregulated in several types of aggressive cancer, and its decrement significantly correlates with poor survival. Here, we aim to investigate the biological function of miR‐199a/b‐3p and its regulation of target genes in breast cancer cells with highly metastatic potential. In addition, we found that miR‐199a/b‐3p expression was much lower in MDA‐MB‐231, CAL120, and HCC1395 breast cancer cells with highly metastatic potential. Functional assays showed that restored miR‐199a/b‐3p expression inhibited MDA‐MB‐231 cell growth, cell‐cycle progression, migration, and invasion. In addition, we experimentally demonstrated that PAK4 was the direct target of miR‐199a/b‐3p, hypo‐expression of PAK4 suppressed proliferation, migration and invasion of MDA‐MB‐231 cells, and overexpression of PAK4 significantly rescued the inhibitory effect of miR‐199a/b‐3p on MDA‐MB‐231 cell growth, migration, and invasion. Further, we also observed that miR‐199a/b‐3p could inactivate the PAK4/MEK/ERK signaling pathway. Thus, miR‐199a/b‐3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway. © 2015 IUBMB Life, 67(10):768–777, 2015
Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells
Authors: Chang Cheng‐Yi , Li Jian‐Ri , Ou Yen‐Chuan , Chen Wen‐Ying , Liao Su‐Lan , Raung Shue‐Ling , Hsiao An‐Lu , Chen Chun‐Jung 
Published: September 2015

AbstractFatal enterovirus type‐71 (EV71) cases are associated with central nervous system infection characterized by inflammatory cell infiltration and activation, cytokine overproduction, and neuronal cell death. Although EV71 antigen has been detected in neurons and glia, the molecular mechanisms underlying EV71‐associated neuroinflammation and neuronal cell death are not fully understood. Using cultured rodent neural cell models, we found that EV71 infection preferentially caused cell death in neurons but not brain‐resident immune cells astrocytes and microglia. Neurons, astrocytes, and microglia responded to EV71 infection by releasing distinct profiles of cytokines, including nitric oxide (NO), tumor necrosis factor‐α (TNF‐α), interleukin (IL)−1β, regulated on activation normal T cell expressed and secreted (RANTES), and glutamate. EV71 infection‐induced neuronal cell death correlated well with the elevated production of NO, TNF‐α, IL‐1β, and glutamate as well as activation of microglia. Exogenous addition studies further demonstrated the neurotoxic potential of NO, TNF‐α, IL‐1β, and glutamate. EV71 infection‐induced cytokine expression was accompanied by activation of protein tyrosine phosphorylation, mitogen‐activated protein kinases (MAPKs), and NF‐κB. Intriguingly, EV71 susceptibility was accompanied by infection‐elevated neuronal human scavenger receptor class B member 2 expression in cultured neural cells with age‐dependent manner. Biochemical and pharmacological studies revealed that after EV71 infection, microglia and accompanied cytokines play an active role in triggering bystander damage to neurons involving the tyrosine kinase/MAPKs/NF‐κB signaling cascade. These data suggest that bystander damage caused by activated glia particularly the microglia could be an alternative mechanism of EV71‐associated neuronal cell death. However, its clinical importance and implication require further investigation. © 2015 IUBMB Life, 67(10):789–800, 2015
Biomedical applications of soy protein: A brief overview
Authors: Tansaz Samira , Boccaccini Aldo R. 
Published: September 2015

AbstractSoy protein (SP) based materials are gaining increasing interest for biomedical applications because of their tailorable biodegradability, abundance, being relatively inexpensive, exhibiting low immunogenicity, and for being structurally similar to components of the extracellular matrix (ECM) of tissues. Analysis of the available literature indicates that soy protein can be fabricated into different shapes, being relatively easy to be processed by solvent or melt based techniques. Furthermore soy protein can be blended with other synthetic and natural polymers and with inorganic materials to improve the mechanical properties and the bioactive behavior for several demands. This review discusses succinctly the biomedical applications of SP based materials focusing on processing methods, properties and applications highlighting future avenues for research. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 553–569, 2016.
Anti‐Inflammatory Effect of Ascochlorin in LPS‐Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down‐Regulation of iNOS, COX‐2 and Proinflammatory Cytokines Through NF‐κB, ERK1/2, and p38 Signaling Pathway
Authors: Lee Sook‐Hyun , Kwak Choong‐Hwan , Lee Sung‐Kyun , Ha Sun‐Hyung , Park Junyoung , Chung Tae‐Wook , Ha Ki‐Tae , Suh Suk‐Jong , Chang Young‐Chae , Chang Hyeun Wook , Lee Young‐Choon , Kang Bong‐Seok , Magae Junji , Kim Cheorl‐Ho 
Published: September 2015

ABSTRACTA natural compound C23H32O4Cl, ascochlorin (ASC) isolated from an incomplete fungus, Ascochyta viciae has been known to have several biological activities as an antibiotic, antifungal, anti‐cancer, anti‐hypolipidemic, and anti‐hypertension agent. In this study, anti‐inflammatory activity has been investigated in lipopolysaccharide (LPS)‐induced murine macrophage RAW 264.7 cells, since ASC has not been observed on the inflammatory events. The present study has clearly shown that ASC (1–50 μM) significantly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreased the gene expression of inducible NO synthase (iNOS) and cyclooxygenase‐2 (COX‐2) in a dose‐dependent manner. Moreover, ASC inhibited the mRNA expression and the protein secretion of interleukin (IL)‐1β and IL‐6 but not tumor necrosis factor (TNF)‐α in LPS‐stimulated RAW 264.7 macrophage cells. In addition, ASC suppressed nuclear translocation and DNA binding affinity of nuclear factor‐κB (NF‐κB). Furthermore, ASC down‐regulated phospho‐extracellular signal‐regulated kinase 1/2 (p‐ERK1/2) and p‐p38. These results demonstrate that ASC exhibits anti‐inflammatory effects in RAW 264.7 macrophage cells. J. Cell. Biochem. 117: 978–987, 2016. © 2015 Wiley Periodicals, Inc.