bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term psychological benefits of cognitive‐behavioral stress management for women with breast cancer: 11‐year follow‐up of a randomized controlled trial
Authors: Stagl Jamie M. , Bouchard Laura C. , Lechner Suzanne C. , Blomberg Bonnie B. , Gudenkauf Lisa M. , Jutagir Devika R. , Glück Stefan , Derhagopian Robert P. , Carver Charles S. , Antoni Michael H. 
Published: March 2015

BACKGROUNDBreast cancer survivors experience long‐term physical and psychological sequelae after their primary treatment that negatively influence their quality of life (QOL) and increase depressive symptoms. Group‐based cognitive‐behavioral stress management (CBSM) delivered after surgery for early‐stage breast cancer was previously associated with better QOL over a 12‐month follow‐up and with fewer depressive symptoms up to 5 years after study enrollment. This 8‐ to 15‐year follow‐up (median, 11 years) of a previously conducted trial (NCT01422551) evaluated whether women in this cohort receiving CBSM had fewer depressive symptoms and better QOL than controls at an 8‐ to 15‐year follow‐up.METHODSWomen with stage 0 to IIIb breast cancer were initially recruited 2 to 10 weeks after surgery and randomized to a 10‐week CBSM intervention or a 1‐day psychoeducational control group. One hundred women (51 CBSM patients and 49 controls) were recontacted 8 to 15 years after study enrollment to participate in a follow‐up assessment. The Center for Epidemiologic Studies–Depression (CES‐D) scale and the Functional Assessment of Cancer Therapy–Breast (FACT‐B) were self‐administered. Multiple regression was employed to evaluate group differences on the CES‐D scale and FACT‐B over and above effects of confounding variables.RESULTSParticipants assigned to CBSM reported significantly lower depressive symptoms (d, 0.63; 95% confidence interval [CI], 0.56‐0.70) and better QOL (d, 0.58; 95% CI, 0.52‐0.65) above the effects of the covariates.CONCLUSIONSWomen who received CBSM after surgery for early‐stage breast cancer reported lower depressive symptoms and better QOL than the control group up to 15 years later. Early implementation of cognitive‐behavioral interventions may influence long‐term psychosocial functioning in breast cancer survivors. Cancer 2015;121:1873–1881. © 2015 American Cancer Society.
Dietary intake of fish, polyunsaturated fatty acids, and survival after breast cancer: A population‐based follow‐up study on Long Island, New York
Authors: Khankari Nikhil K. , Bradshaw Patrick T. , Steck Susan E. , He Ka , Olshan Andrew F. , Shen Jing , Ahn Jiyoung , Chen Yu , Ahsan Habibul , Terry Mary Beth , Teitelbaum Susan L. , Neugut Alfred I. , Santella Regina M. , Gammon Marilie D. 
Published: March 2015

BACKGROUNDIn laboratory experiments, ω‐3 polyunsaturated fatty acids (PUFAs) have been found to reduce inflammatory eicosanoids resulting from ω‐6 PUFA metabolism via competitive inhibition, and the ω‐3‐induced cytotoxic environment increases apoptosis and reduces cell growth in breast cancer cells. To the authors' knowledge, epidemiologic investigations regarding whether dietary ω‐3 PUFA intake benefits survival after breast cancer are limited and inconsistent.METHODSThe authors used resources from a population‐based follow‐up study conducted on Long Island, New York, among 1463 women newly diagnosed with first primary breast cancer who were interviewed an average of approximately 3 months after diagnosis to assess risk and prognostic factors, including dietary intake (using a food frequency questionnaire). Vital status was determined through 2011, yielding a median follow‐up of 14.7 years and 485 deaths. Adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards regression.RESULTSAll‐cause mortality was reduced among women with breast cancer reporting the highest quartile of intake (compared with never) for tuna (HR, 0.71; 95% CI, 0.55‐0.92), other baked/broiled fish (HR, 0.75; 95% CI, 0.58‐0.97), and the dietary long‐chain ω‐3 PUFAs docosahexaenoic acid (HR, 0.71; 95% CI, 0.55‐0.92) and eicosapentaenoic acid (HR, 0.75; 95% CI, 0.58‐0.97).CONCLUSIONSAll‐cause mortality was reduced by 16% to 34% among women with breast cancer who reported a high intake of fish and long‐chain ω‐3 PUFAs. Long‐chain ω‐3 PUFA intake from fish and other dietary sources may provide a potential strategy to improve survival after breast cancer. Cancer 2015;121:2244–2252. © 2015 American Cancer Society.
Effect of lapatinib on oral digoxin absorption in patients
Authors: Koch Kevin M. , Smith Deborah A. , Botbyl Jeff , Arya Nikita , Briley Linda P. , Cartee Leanne , White Jane Holshouser , Beyer Jennifer , Dar Mohammed M. , Chung Hyun Choel , Chu Quincy , Bang Yung‐Jue 
Published: March 2015

AbstractThe potential for an interaction between lapatinib and absorption of the P‐glycoprotein (ABCB1) substrate digoxin at a therapeutic dose in breast cancer patients was characterized. Seventeen women with HER2‐positive metastatic breast cancer received a single oral 0.5‐mg dose of digoxin on days 1 and 9 and oral lapatinib 1500 mg once daily on days 2 through 9. Digoxin pharmacokinetic parameters were determined on day 1 (digoxin administration alone) and on day 9 (coadministration of lapatinib and digoxin), and parameters were compared to determine the effects of lapatinib on digoxin absorption. Concomitant medications that could affect ABCB1 were accounted for. Lapatinib 1500 mg/day increased digoxin absorption approximately 80%, implicating lapatinib inhibition of intestinal ABCB1‐mediated efflux. In summary, coadministration of lapatinib with narrow therapeutic index drugs that are substrates of ABCB1 should be undertaken with caution and dose adjustment should be considered.
Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed‐dose combination products and metformin immediate‐release tablet sourced from various countries
Authors: Chitnis Shripad D. , Han Yi , Yamaguchi Masayuki , Mita Sachiko , Zhao Rong , Sunkara Gangadhar , Kulmatycki Kenneth 
Published: March 2015

AbstractMetformin is the first‐line pharmacotherapy choice for treating type‐2 diabetes mellitus, alone or in combination with other antidiabetic drugs. During the development of immediate‐release (IR) metformin containing novel fixed‐dose combination (FDC) products, several health‐authorities require sponsors to demonstrate bioequivalence between FDC products and the country‐sourced metformin for market approval. Eight bioequivalence studies that compared metformin/vildagliptin FDC product (test) to metformin IR tablet sourced from various countries (reference) were conducted. A population pharmacokinetic (PPK) analysis of pooled metformin concentration–time data was performed to evaluate whether country‐sourced metformin is a significant covariate. The PPK analysis demonstrated that there was no clinically relevant effect of metformin source or race/ethnicity on metformin pharmacokinetics. Also, noncompartmental analysis conducted showed that 90%CI of geometric mean ratios of test to reference metformin formulations, calculated for maximum‐concentration and exposure parameters, were within the 80%–125% criteria, indicating comparable metformin exposure regardless of the country‐sourced metformin IR formulation. These results are consistent with the biopharmaceutics properties of metformin and provide scientific evidence that after assessing in vitro dissolution of novel FDC formulation, additional bioequivalence studies with multiple countries' reference products may not be required once bioequivalence is established with 1 country‐sourced IR metformin formulation.
Business Strategy for Climate Change: An ASEAN Perspective
Authors: Amran Azlan , Ooi Say Keat , Wong Cheng Yew , Hashim Fathyah 
Published: March 2015

AbstractBusiness operations have been severely impacted by the increasing frequency and intensity of extreme weather conditions affecting economic development. Consequently, public pressure has been directed at businesses to build resilient and sustainable operations, especially in ASEAN countries, whose fragile natural environments make them among the most vulnerable to climate change. To better understand organisational responses, this study investigated the influence of internal resources and geographical regional effects on climate change business strategy. It provided empirical evidence from ASEAN countries based on the combined views of institutional and resource‐based theories. Generally, ASEAN businesses were aware of climate change, and focused on strategies of fuel efficiency and greenhouse gas emissions reduction. Even though few businesses integrated climate change into their business strategy, there are several factors (board of directors with international experience, organisational slack, and country effect) that influence ASEAN climate change business strategy. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
A Strategic Approach to CSR Communication: Examining the Impact of Brand Familiarity on Consumer Responses
Authors: Türkel Selin , Uzunoğlu Ebru , Kaplan Melike Demirbağ , Vural Beril Akıncı 
Published: March 2015

AbstractDespite the widely acknowledged importance of corporate social responsibility (CSR) communications, our knowledge is limited with regard to various factors affecting consumer responses to such communication efforts. This paper aims to identify the extent to which prior brand familiarity influences consumer responses to CSR communications through a controlled experiment, exploring whether the use of different communication functions for environmental domain of CSR (i.e., publicity and advertising) generates any different effect on these responses. Findings reveal that familiar and unfamiliar brands do not differ from each other with regard to consumer attitude toward message, but elicit dissimilar responses in terms of attitude toward brand and purchase intentions. The study leads to managerial implications regarding the effective formulation and dissemination of CSR‐related messages in order to achieve stakeholder engagement. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
The Quality of Disclosures on Environmental Policy: The Profile of Financial Intermediaries
Authors: Alberici Adalberto , Querci Francesca 
Published: March 2015

ABSTRACTThis study investigates the quality of voluntary disclosures on environmental policy by financial intermediaries (FIs), analyzing the Global Reporting Initiative's data. Through k‐means cluster analysis, four segments of FIs are identified. Our results show a heterogeneous reality. The quality of disclosures is associated to the FIs’ attributes and the home country's characteristics: FIs’ size and operating profitability, national economic wealth, and national environmental performance. No association is found with the FIs’ business area or their quotation on the stock market. The FIs’ relevance for their domestic economy is not significant either. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment.
Transformed periodic orbit mechanism of low frequency oscillations in power systems
Authors: Wang Gang , Shen Chen , Fu Lijun , Cui Zhiyong , Ye Zhihao 
Published: March 2015

SUMMARYSome low frequency oscillations (LFOs) with constant amplitude in power systems cannot be explained by the mechanisms such as negative damping, forced oscillation, autoparametric resonance, and bifurcation. In this paper, the concept of transformed periodic orbits is introduced to describe the earlier unexplained periodic steady‐state phenomena in power systems. The algorithm of calculating the transformed periodic orbit is presented based on the trapezoidal integration method. Then, a novel mechanism of LFOs is proposed; that is, a transformed periodic orbit emerges when bifurcations or large disturbances occur in power systems. This kind of LFOs can be eliminated by decreasing the generator output power greatly. Simulations on a single‐machine infinite‐bus system and the IEEE 9‐bus system have demonstrated the rationality of the proposed mechanism. Copyright © 2015 John Wiley & Sons, Ltd.
Derivation of chondrocyte and osteoblast reporter mouse embryonic stem cell lines
Authors: Fu Yu , Maye Peter 
Published: March 2015

SummaryWith the establishment of methods that provide evidence for the generation of chondrocyte and osteoblast cell types from ESCs, there is a need for reagents that will enable their further characterization. Here we report on the derivation of chondrocyte and osteoblast reporter ESCs from previously generated and characterized transgenic mouse lines, Collagen type 2 alpha 1(Col2a1)‐ECFP, Bone Sialoprotein (BSP)‐Topaz, and BSP‐Topaz/Dentin Matrix Protein 1 (DMP1)‐Cherry dual reporter mice. Col2a1‐ECFP is highly expressed in chondrocytes, while BSP‐Topaz and DMP1‐Cherry are highly expressed in osteoblasts and osteocytes, respectively. These new skeletal reporter mouse ESC lines will serve as valuable reagents to investigate the functionality of ESC derived chondrocyte and osteoblast cell types. genesis 53:294–298, 2015. © 2015 Wiley Periodicals, Inc.
DNA methylation in individuals with anorexia nervosa and in matched normal‐eater controls: A genome‐wide study
Authors: Booij Linda , Casey Kevin F. , Antunes Juliana M. , Szyf Moshe , Joober Ridha , Israël Mimi , Steiger Howard 
Published: March 2015

ABSTRACTObjectiveEvidence associates anorexia nervosa (AN) with epigenetic alterations that could contribute to illness risk or entrenchment. We investigated the extent to which AN is associated with a distinct methylation profile compared to that seen in normal‐eater women.MethodGenome‐wide methylation profiles, obtained using DNA from whole blood, were determined in 29 women currently ill with AN (10 with AN‐restrictive type, 19 with AN‐binge/purge type) and 15 normal‐weight, normal‐eater control women, using 450 K Illumina bead arrays.ResultsRegardless of type, AN patients showed higher and less‐variable global methylation patterns than controls. False Discovery Rate corrected comparisons identified 14 probes that were hypermethylated in women with AN relative to levels obtained in normal‐eater controls, representing genes thought to be associated with histone acetylation, RNA modification, cholesterol storage and lipid transport, and dopamine and glutamate signaling. Age of onset was significantly associated with differential methylation in gene pathways involved in development of the brain and spinal cord, while chronicity of illness was significantly linked to differential methylation in pathways involved with synaptogenesis, neurocognitive deficits, anxiety, altered social functioning, and bowel, kidney, liver and immune function.DiscussionAlthough pre‐existing differences cannot be ruled out, our findings are consistent with the idea of secondary alterations in methylation at genomic regions pertaining to social‐emotional impairments and physical sequelae that are commonly seen in AN patients. Further investigation is needed to establish the clinical relevance of the affected genes in AN, and, importantly, reversibility of effects observed with nutritional rehabilitation and treatment. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:874–882)
Childhood trauma and cortisol awakening response in symptomatic patients with anorexia nervosa and bulimia nervosa
Authors: Monteleone Alessio Maria , Monteleone Palmiero , Serino Ismene , Scognamiglio Pasquale , Di Genio Monica , Maj Mario 
Published: March 2015

ABSTRACTObjectiveExposure to trauma during childhood is a risk factor for eating disorders (EDs) in adulthood. The biological mechanisms underlying such increased risk seem to involve the endogenous stress response system (i.e., the hypothalamic‐pituitary‐adrenal [HPA] axis), which undergoes trauma‐induced functional changes that may persist later in life. In the present study, we examined the effects of childhood trauma experiences on HPA‐axis activity, comparing saliva cortisol awakening response (CAR) in adult patients with anorexia nervosa (AN) or bulimia nervosa (BN) with CAR in adult healthy controls.MethodTwenty‐three patients with symptomatic AN, 21 patients with symptomatic BN, and 29 healthy women collected saliva samples at awakening and again after 15, 30, and 60 min. Participants also completed the Childhood Trauma Questionnaire and eating‐related psychopathological rating scales.ResultsAccording to the Childhood Trauma Questionnaire, 13 individuals with AN and 12 individuals with BN, but none of the healthy women, reported childhood maltreatment. Compared with the control group, the non‐maltreated AN patient group exhibited an enhanced CAR, whereas the group of non‐maltreated BN patients showed a normal CAR. Moreover, both AN and BN patient groups with childhood maltreatment exhibited statistically significant blunting of CAR compared with non‐maltreated groups.DiscussionThe present findings add to the evidence supporting the concept that there is a dysregulation of HPA‐axis activity in symptomatic patients with EDs and suggest that childhood trauma exposure may contribute to such dysregulation. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48: 615–621)
A prospective study of effects of prenatal maternal stress on later eating‐disorder manifestations in affected offspring: Preliminary indications based on the project ice storm cohort
Authors: St‐Hilaire Annie , Steiger Howard , Liu Aihua , Laplante David P. , Thaler Lea , Magill Tara , King Suzanne 
Published: March 2015

ABSTRACTBackground Research associates maternal stress exposures (especially when occurring late in gestation) with heightened risk of subsequent emotional and behavioral problems in affected offspring. However, as yet, no study has examined the association between prenatal maternal stress (PNMS) and affected children's risk of anorexia‐ or bulimia‐type eating disturbances.Objective To study the influences of PNMS on later disordered eating in exposed offspring.Method We used the Eating Attitudes Test (EAT)‐26 to measure eating attitudes and behaviors in 54 thirteen‐year olds whose mothers had been exposed, while pregnant with these children, to the 1998 Quebec Ice Storm—a natural disaster regarded as a model of exposure to severe environmental stress. Mothers' stress was measured shortly after exposure to the storm using established indices of objective and subjective stress.Results Hierarchical multiple linear regression analyses indicated that once variance owing to children's body mass index and sex was accounted for, stress exposures during the third trimester of pregnancy predicted elevated EAT‐26 scores in affected children—perhaps even more so when levels of objective stress were high.Discussion Third trimester exposure to PNMS, especially when objectively severe, seems to be associated with increased eating‐disorder‐linked manifestations in affected early adolescents. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:512–516)
Negative affect prior to and following overeating‐only, loss of control eating‐only, and binge eating episodes in obese adults
Authors: Berg Kelly C. , Crosby Ross D. , Cao Li , Crow Scott J. , Engel Scott G. , Wonderlich Stephen A. , Peterson Carol B. 
Published: March 2015

ABSTRACTObjectiveThe objective was to examine the trajectory of five types of negative affect (global negative affect, fear, guilt, hostility, sadness) prior to and following three types of eating episodes (overeating in the absence of loss of control [OE‐only], loss of control eating in the absence of overeating [LOC‐only], and binge eating) among obese adults using ecological momentary assessment (EMA).MethodFifty obese adults (84% female) completed a two‐week EMA protocol during which they were asked to record all eating episodes and rate each episode on continua of overeating and loss of control. Momentary measures of global negative affect, fear, guilt, hostility, and sadness were assessed using an abbreviated version of the Positive and Negative Affect Schedule (PANAS). Trajectories for each of the five types of negative affect were modeled prior to and following episodes of OE‐only, LOC‐only, and binge eating.ResultsConsistent with previous findings, global negative affect and Guilt increased prior to and decreased following binge eating episodes (all ps < .05). Guilt also decreased following OE‐only episodes (p < .05).DiscussionThese results are consistent with the affect regulation model of binge eating and suggest that binge eating may function to regulate global negative affect, and more specifically, guilt among obese adults. These data suggest that the relationship between negative affect and binge eating may not be unique to individuals with clinical eating disorders and indicate that targeting negative affect may be an effective strategy for the treatment of binge eating in the context of obesity. © 2015 Wiley Periodicals, Inc (Int J Eat Disord 2015; 48:641–653)
Time trends in lifetime incidence rates of first‐time diagnosed anorexia nervosa and bulimia nervosa across 16 years in a danish nationwide psychiatric registry study
Authors: Steinhausen Hans‐Christoph , Jensen Christina Mohr 
Published: March 2015

ABSTRACTObjectiveTo study recent time trends in the incidence of diagnosed anorexia nervosa (AN) and bulimia nervosa (BN) based on nationwide psychiatric register data.MethodThe Danish Psychiatric Central Research Registry was used to identify the incidence of diagnosed cases with AN and BN at the ages of 4–65 years from 1995 to 2010. Age‐ and sex‐adjusted incidence rates per 100,000 person‐years were calculated and were adjusted for time trends in the total number of people diagnosed in psychiatry. Time trends were analyzed using JoinPoint regression analysis.ResultsA total of N = 5,902 persons had a first‐time incidence of AN, and a total of N = 5,113 had first‐time incidence of BN. Incidence rates increased for AN from 6.4 to 12.6 per 100,000 person‐years, and for BN from 6.3 to 7.2 per 100,000 person‐years. In 2010, the male‐to‐female ratio was 1:8 for AN, and 1:20 for BN. There was an earlier onset for AN than for BN, and age at incidence decreased during the observation period for AN but not for BN. A sizeable part of the increasing incidence rates for AN and in particular, the younger AN age groups, could be attributed to an increase in the total number of N = 249,607 persons with first‐time diagnoses in psychiatry.DiscussionIncidence rates had increased slightly for AN, but were stable for BN across 16 years in this nationwide study and to a large extent were reflective of a general increase in diagnosed mental disorders. (Int J Eat Disord 2015; 48:845–850)