bluuebunny/crossref_metadata_2025_split huggingface dataset:
User development through proactive knowledge transfer
Authors: Daghfous Abdelkader , Ahmad Norita 
Published: January 2015

Purpose
– The purpose of this paper is to elucidate the concept of user development which consists of proactively transferring knowledge to potential users of IT innovations in order to increase the likelihood of innovation adoption and diffusion.

Design/methodology/approach
– An exploratory approach was adopted using three case organizations representing different sectors. These organizations represent the public, the semi-government, and the private sectors.

Findings
– The findings show that proactive knowledge transfer builds the requisite absorptive capacity of users to understand, adopt new and complex systems and technologies, and effectively integrate them into their organizations, hence increasing their likelihood of adopting such innovations. The findings also show that effective user development hinges on proper selection of potential users and on goals alignment between the innovating firm and the selected users.

Research limitations/implications
– The framework could be further refined through more diverse case studies from a broader range of companies. Survey-based investigations are also needed to operationalize the constructs and explore its effects on the performance of the innovating firm. In practice, innovation managers should be more proactive by recognizing the value of knowledge transfer when it comes to expanding and accelerating the adoption and diffusion of their innovations.

Originality/value
– This paper illustrates the importance of proactive knowledge transfer, especially in situation that call for absorptive capacity building. This paper also opens new opportunities for innovation managers to sell their innovations faster and to a wider market, and perhaps even altering the trajectory of particular innovations.
S&P 500 index addition, liquidity management and Tobin's Q
Authors: Platikanova Petya 
Published: January 2015

AbstractThis study examines the revision in cash holdings and the market valuation of investment opportunities of 475 firms added to the Standard & Poor's 500 (S&P 500) stock market index from 1980 to 2010. We find that newly indexed firms have evolved to significantly lower cash balances, which we partially explain by the decreasing growth opportunities following index inclusion. Consistent with index inclusion loosening financial constraints, we document a larger decrease in cash for index inclusions in sectors with high financial dependence. We sort S&P 500 inclusions by corporate governance quality but do not find any empirical support that changes in cash and Tobin's Q are related to management entrenchment.
Second‐generation antipsychotic effect on cognition in patients with schizophrenia—a meta‐analysis of randomized clinical trials
Authors: Nielsen R. E. , Levander S. , Kjaersdam Telléus G. , Jensen S. O. W. , Østergaard Christensen T. , Leucht S. 
Published: January 2015

ObjectiveTo investigate the effect of second‐generation antipsychotics on cognitive function in patients diagnosed with schizophrenia or schizoaffective disorder.MethodMultiple‐treatments meta‐analysis model.ResultsOn cognitive composite score, sertindole was superior to clozapine, effect size (ES) 0.87; 95% CI: 0.12–1.63, quetiapine, ES 0.75; 95% CI: 0.00–1.49, and first‐generation antipsychotics (FGAs), ES 0.89; 95% CI: 0.14–1.64. Analyses on each cognitive domain showed clozapine, ES 0.37; 95% CI: 0.00–0.74, olanzapine, ES 0.31; 95%CI: 0.02–0.59, quetiapine, ES 0.34; 95% CI: 0.03–0.64, and FGAs, ES 0.51; 95% CI: 0.18–0.83 performing poorer on verbal working memory than ziprasidone, as well as FGAs performing poorer than risperidone, ES 0.31; 95% CI: 0.04–0.58. On executive function, sertindole performed better than clozapine, ES 0.82; 95% CI: 0.06–1.58, olanzapine, ES 0.81; 95% CI: 0.07–1.55, quetiapine, ES 0.76; 95% CI: 0.02–1.51, ziprasidone, ES 0.90; 95% CI: 0.14–1.67, and FGAs, ES 0.83; 95% CI: 0.08–1.58. On processing speed, FGAs performed poorer than sertindole, ES 0.97; 95% CI: 0.02–1.91, and quetiapine, ES 0.36; 95% CI: 0.01–0.72. On long‐term verbal working memory, clozapine performed poorer than olanzapine, ES 0.41; 95% CI: 0.06–0.76. On verbal fluency, FGAs performed poorer than olanzapine, ES 0.26; 95% CI: 0.01–0.50, and clozapine, ES 0.44; 95% CI: 0.06–0.81. Lastly, FGAs, ES 0.41; 95% CI: 0.04–0.78, and clozapine, ES 0.44; 95% CI: 0.05–0.83, performed poorer on visuospatial skill compared to olanzapine.ConclusionThe meta‐analysis was able to detect some trends in the data analyzed, but did not show any drug having a uniform positive cognitive profile.
Prevalence of internet gaming disorder in German adolescents: diagnostic contribution of the nine DSM‐5 criteria in a state‐wide representative sample
Authors: Rehbein Florian , Kliem Sören , Baier Dirk , Mößle Thomas , Petry Nancy M. 
Published: January 2015

AbstractBackground and aimsInternet gaming disorder (IGD) is included as a condition for further study in Section 3 of the DSM‐5. Nine criteria were proposed with a threshold of five or more criteria recommended for diagnosis. The aims of this study were to assess how the specific criteria contribute to diagnosis and to estimate prevalence rates of IGD based on DSM‐5 recommendations.DesignLarge‐scale, state‐representative school survey using a standardized questionnaire.SettingGermany (Lower Saxony).ParticipantsA total of 11 003 ninth‐graders aged 13–18 years (mean = 14.88, 51.09% male).MeasurementsIGD was assessed with a DSM‐5 adapted version of the Video Game Dependency Scale that covered all nine criteria of IGD.FindingsIn total, 1.16% [95% confidence interval (CI) = 0.96, 1.36] of respondents were classified with IGD according to DSM‐5 recommendations. IGD students played games for longer periods, skipped school more often, had lower grades in school, reported more sleep problems and more often endorsed feeling ‘addicted to gaming’ than their non‐IGD counterparts. The most frequently reported DSM‐5 criteria overall were ‘escape adverse moods’ (5.30%) and ‘preoccupation’ (3.91%), but endorsement of these criteria rarely related to IGD diagnosis. Conditional inference trees showed that the criteria ‘give up other activities’, ‘tolerance’ and ‘withdrawal’ were of key importance for identifying IGD as defined by DSM‐5.ConclusionsBased on a state‐wide representative school survey in Germany, endorsement of five or more criteria of DSM‐5 internet gaming disorder (IGD) occurred in 1.16% of the students, and these students evidence greater impairment compared with non‐IGD students. Symptoms related to ‘give up other activities’, ‘tolerance’ and ‘withdrawal’ are most relevant for IGD diagnosis in this age group.
Strain hypothesis ofToxoplasma gondiiinfection on the outcome of human diseases
Authors: Xiao J. , Yolken R. H. 
Published: January 2015

AbstractThe intracellular protozoanToxoplasma gondiiis an exceptionally successful food and waterborne parasite that infects approximately 1 billion people worldwide. Genotyping ofT. gondiiisolates from all continents revealed a complex population structure. Recent research supports the notion thatT. gondiigenotype may be associated with disease severity. Here, we (1) discuss molecular and serological approaches for designation ofT. gondiistrain type, (2) overview the literatures on the association ofT. gondiistrain type and the outcome of human disease and (3) explore possible mechanisms underlying these strain‐specific pathology and severity of human toxoplasmosis. Although no final conclusions can be drawn, it is clear that virulent strains (e.g. strains containing type I or atypical alleles) are significantly more often associated with increased frequency and severity of human toxoplasmosis. The significance of highly virulent strains can cause severe diseases in immunocompetent patients and might implicated in brain disorders such as schizophrenia should led to reconsideration of toxoplasmosis. Further studies that combine parasite strain typing and human factor analysis (e.g. immune status and genetic background) are required for better understanding of human susceptibility or resistance to toxoplasmosis.
Single‐incision laparoscopic totally extraperitoneal obturator hernia repair in a patient on antiplatelet therapy: A case report
Authors: Wakasugi Masaki , Masuzawa Toru , Tei Mitsuyoshi , Omori Takeshi , Ueshima Shigeyuki , Tori Masayuki , Akamatsu Hiroki 
Published: January 2015

AbstractAn 83‐year‐old woman who complained of right lower limb discomfort was diagnosed with a right obturator hernia by CT scan. On examination, she had a soft and flat abdomen without signs of peritoneal irritation. The Howship–Romberg sign was present. She had a history of vasospastic angina and paroxysmal supraventricular tachycardia, and took aspirin and dipyridamole until she was admitted to the hospital. Exploratory laparoscopy identified a spontaneously reduced small bowel from the right obturator canal, but there were no signs of ischemic and necrotic bowel. The patient underwent SILS for totally extraperitoneal obturator hernia repair without a dissection balloon. The patient recovered without perioperative complications such as hemorrhage and thrombotic episodes. She remains well, and CT scans showed no signs of obturator hernia recurrence at the 7‐month follow‐up.
New suture: Tail clinch knot for transabdominal preperitoneal hernia repair
Authors: Uchida Kazunori , Morimoto Hiroshi , Tashiro Hirotaka , Ohdan Hideki , Yamamoto Manabu 
Published: January 2015

AbstractIntroductionThere is some controversy regarding the proper surgical method for inguinal hernia repair and whether transabdominal preperitoneal or totally extraperitoneal repair should be used. The greatest difference between these procedures is the need for absorbable sutures to close the peritoneal incision.Materials and Surgical TechniqueThe clinch knot is a kind of slip knot that is used for securing a fishing lure, hook, or swivel to a fishing line. This knot is used by fishermen and has historically proven to be secure.DiscussionWhen a clinch know is placed at the tail end of a suture thread, a running suture can be started without knot tying.
Staging laparoscopy leads to rapid induction of chemotherapy for unresectable pancreatobiliary cancers
Authors: Hashimoto Daisuke , Chikamoto Akira , Sakata Kazuya , Nakagawa Shigeki , Hayashi Hiromitsu , Ohmuraya Masaki , Hirota Masahiko , Yoshida Naoya , Beppu Toru , Baba Hideo 
Published: January 2015

AbstractPreoperatively evaluating the resectability of pancreatobiliary cancers is difficult. The aim of this study was to investigate the benefit of staging laparoscopy in unresectable pancreatobiliary cancers. Between 2010 and 2013, 25 patients with pancreatobiliary cancers underwent staging laparoscopy after conventional tumor staging; they were compared with 10 patients who had unresectable or metastatic tumors that were found during laparotomy. Staging laparoscopy did not show unresectable factors in 11 patients, and resections were performed in these patients. Unresectable factors were found in other 14 patients who underwent staging laparoscopy. In these patients, chemotherapy was started after median postoperative day 3 (range, 2–10 days). This period was significantly longer in patients who received unnecessary laparotomy; chemotherapy was started after median postoperative day 11 (range, 6–15 days). These results suggest that staging laparoscopy, while avoiding laparotomy with unsuccessful resection, can lead to rapid induction of chemotherapy for unresectable pancreatobiliary cancers.
Laparoscopic repair for intraoperative injury of the right hepatic artery during cholecystectomy
Authors: Fujioka Shuichi , Fuke Azusa , Funamizu Naotake , Nakayoshi Tomoko , Okamoto Tomoyoshi , Yanaga Katsuhiko 
Published: January 2015

AbstractRight hepatic artery (RHA) injury is a complication that occurs during laparoscopic cholecystectomy, which can sometimes cause hepatic artery pseudoaneurysm or ischemic hepatic necrosis. Therefore, RHA should be managed carefully. Herein, we report a case of intraoperative RHA injury that was successfully repaired during laparoscopic cholecystectomy. Bleeding was controlled prior to the cholecystectomy with vascular clamp forceps that had been inserted through an additional trocar, and repair of the RHA injury was then performed laparoscopically. The postoperative course was uneventful, and patency of the RHA and its sectional arteries were confirmed by CT arteriography. Laparoscopic repair of minor RHA injuries can be managed safely if bleeding is adequately controlled.
Higher Cesarean Delivery Rates are Associated with Higher Infant Mortality Rates in Industrialized Countries
Authors: Xie Ri‐hua , Gaudet Laura , Krewski Daniel , Graham Ian D. , Walker Mark C. , Wen Shi Wu 
Published: January 2015

AbstractBackgroundRecent data indicate that more than half of high‐income industrialized countries have a cesarean delivery rate of > 25 percent, which is higher than the appropriate level considered by most health professionals worldwide.MethodsData for 31 high‐income industrialized countries in 2010 (or the nearest year) obtained from the World Health Organization, Organization for Economic Cooperation and Development, World Bank, and individual countries were analyzed in this study. We examined the correlation between cesarean delivery rate and infant mortality rate with Pearson correlation coefficient analysis, and examined the independent effect of cesarean delivery on infant mortality with multiple linear regression analyses.ResultsThe cesarean delivery and infant mortality rates varied substantially among the included countries: from 15.6 to 50.0 percent and from 1.9 per to 6.8 per 1,000 live births, respectively. Cesarean delivery rates were positively correlated with infant mortality rates (Pearson correlation coefficient: 0.41, p < 0.05). The association remained after adjustment for maternal age, infant sex, per capita GDP, and the Gini index (p < 0.03), but disappeared after further adjustment for preterm birth (p = 0.07). In a sensitivity analysis, the results were not appreciably affected by excluding births at < 22 weeks of gestation, by weighting the data by the number of births in each country, or by excluding data from particular countries with possible measurement issues (USA, Greece).ConclusionsA higher cesarean delivery rate is associated with higher infant mortality rate among these high‐income industrialized countries. One of the mechanisms by which cesarean delivery affects infant mortality is through iatrogenic prematurity.
Patient‐reported ‘ever had’ and ‘current’ long‐term physical symptoms after prostate cancer treatments
Authors: Gavin Anna T. , Drummond Frances J. , Donnelly Conan , O'Leary Eamonn , Sharp Linda , Kinnear Heather R. 
Published: January 2015

ObjectiveTo investigate the prevalence of physical symptoms that were ‘ever’ and ‘currently’ experienced by survivors of prostate cancer at a population level, to assess burden and thus inform policy to support survivors.Patients and MethodsThe study included 3 348 men surviving prostate cancer for 2–18 years after diagnosis. A cross‐sectional, postal survey of 6 559 survivors diagnosed 2–18 years ago with primary, invasive prostate cancer (ICD10‐C61) identified via national, population‐based cancer registries in Northern Ireland and Republic of Ireland. Questions included symptoms at diagnosis, primary treatments and physical symptoms (erectile dysfunction [ED]/urinary incontinence [UI]/bowel problems/breast changes/loss of libido/hot flashes/fatigue) experienced ‘ever’ and at questionnaire completion (‘current’). Symptom proportions were weighted by age, country and time since diagnosis. Bonferroni corrections were applied for multiple comparisons.ResultsAdjusted response rate 54%; 75% reported at least one ‘current’ physical symptom (‘ever’ 90%), with 29% reporting at least three. Prevalence varied by treatment. Overall, 57% reported current ED and this was highest after radical prostatectomy (RP, 76%) followed by external beam radiotherapy with concurrent hormone therapy (HT, 64%). UI (overall ‘current’ 16%) was highest after RP (‘current’ 28%; ‘ever’ 70%). While 42% of brachytherapy patients reported no ‘current’ symptoms, 43% reported ‘current’ ED and 8% ‘current’ UI. ‘Current’ hot flashes (41%), breast changes (18%) and fatigue (28%) were reported more often by patients on HT.ConclusionSymptoms after prostate cancer treatment are common, often multiple, persist long‐term and vary by treatment method. They represent a significant health burden. An estimated 1.6% of men aged >45 years are survivors of prostate cancer and currently experiencing an adverse physical symptom. Recognition and treatment of physical symptoms should be prioritised in patient follow‐up. This information should facilitate men and clinicians when deciding about treatment as differences in survival between radical treatments is minimal.
The prevalence of Vitamin D deficiency is higher in adult survivors of childhood cancer
Authors: Neville Kristen A. , Walker Jan L. , Cohn Richard J. , Cowell Christopher T. , White Christopher P. 
Published: January 2015

SummaryBackgroundIt is unclear whether the rate of vitamin D deficiency in paediatric cancer survivors is higher than in the background population, and whether this is of pathological significance.Patients and Methods25OHD was measured in a previously studied group of 208 survivors (n = 108 paediatric 5–17 years, n = 99 adults 18–39 years) and compared with paediatric (5–17 years; n = 132) and adult controls (25–35 years; n = 1393 from the AusDiab cohort) adjusted for age and gender. Relationships with treatment factors (irradiation, bone marrow transplantation and intensity of treatment) along with overweight/obesity (defined by BMI), abdominal adiposity (waist:height ratio >0·5) and hyperinsulinism or abnormal glucose tolerance (HI/aGT) were sought.Results25OHD concentrations were similar in paediatric survivors compared with controls (64·3 ± 21·6 nmol/l vs 66·3 ± 22·8 nmol/l), with no effect of age or gender. Adjusted for gender, rates of 25OHD deficiency (<50 nmol/l) were higher in adult survivors compared with AusDiab controls (42·4% vs 20·8%; P < 0·001). Apart from time since diagnosis (P = 0·03), no relationship with treatment factors was detected. In multivariate regression analysis, abdominal adiposity (P = 0·001), but not overweight/obesity by BMI status nor HI/aGT, was associated with significantly lower 25OHD concentrations.ConclusionsAdult survivors are at increased risk of abnormalities in vitamin D compared to the background population, probably reflecting longer time since diagnosis. Like others, we have not identified any contributory treatment‐related factors. Vitamin D deficiency does not appear to be associated with the development of abnormal glucose tolerance in this population.
Genetic association between Interleukin‐17A gene polymorphisms and the pathogenesis of Graves’ disease in the Han Chinese population
Authors: Qi Yicheng , Zheng Huan , Liu Nan , Guo Ting , Zhu Wei , Wang Shu , Cui Bin , Ning Guang 
Published: January 2015

SummaryObjectiveGraves’ disease, one of the commonest autoimmune disorders, has a complex genetic basis. Interleukin‐17A (IL‐17A) is an important cytokine involved in innate and adaptive immune responses. This case–control study sought to investigate genetic association between the IL‐17A gene and the process of Graves’ disease (GD).Design and methodsOur pilot study was performed on a cohort from Shanghai, which included 713 patients with GD and 756 healthy controls. A replicate cohort was from Xiamen, recruiting 444 patients with GD and 427 healthy subjects. Six single nucleotide polymorphisms (SNPs) (rs4711998, rs3819024, rs2275913, rs8193037, rs3819025 and rs3748067) within the IL‐17A gene were genotyped by the SNPstream Genotyping Systems and Taqman PCR method.ResultsIn Shanghai cohorts, the frequencies of rs8193037 alleles were strongly different between patients with Graves’ disease (G, 87·6% and A, 12·4%) and healthy controls (G, 91·4% and A, 8·6%) (P = 0·00067). The A carriers were associated with increased Graves’ disease risks when compared with the G carriers (OR = 1·51, 95%CI = 1·19‐1·92). In replicate cohorts, the proportion of individuals carrying the A allele of rs8193037 was significantly higher in patients with Graves’ disease than in controls [Graves’ disease vs control, 14·3% vs 9·1%, OR = 1·66 (95% CI: 1·23–2·24), Pallele = 0·0082]. In addition, rs8193037 and rs3748067 were found to be different in both genotype and allele distributions in Graves’ disease‐associated ophthalmopathy patients and controls in Shanghai cohorts. Haplotype association analysis also identified five main haplotypes of those six SNPs.ConclusionThese results suggested that the polymorphism of IL‐17A rs8193037 was strongly associated with Graves’ disease susceptibility in the Chinese Han population.z
Hymenoscyphus fraxineus can directly infect intact current‐year shoots of Fraxinus excelsior and artificially exposed leaf scars
Authors: Kräutler K. , Treitler R. , Kirisits T. 
Published: January 2015

SummaryHymenoscyphus fraxineus, the causal agent of ash dieback, was inoculated onto intact, unwounded current‐year shoots and leaf scars of 4‐year‐old, potted Fraxinus excelsior seedlings. Pieces of ash wood colonized by the fungus were used as inoculum. Three of 25 (12%) of the inoculated intact shoots and nine of 25 (36%) of the inoculated leaf scars were infected by H. fraxineus and developed typical symptoms of ash dieback, including necrotic lesions on the shoot surface and wood discoloration as well as shoot and leaf wilting distal to the inoculation site. No symptoms occurred on control seedlings, which had been inoculated in the same way but with sterile wood pieces. Visible necrotic lesions on shoots and wood discoloration were statistically significantly longer in proximal than in distal direction from the inoculation site, a pattern which resembles symptoms after natural infection. The ash dieback pathogen was re‐isolated from nine of 12 (75%) of the symptomatic seedlings. These results provide indirect supportive evidence that the fungus infects shoots via leaves and shows that it is able, under experimental conditions using a massive mycelial inoculum, to directly infect intact, unwounded current‐year shoots of its main host in Europe.