bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of acceptance and commitment therapy on fatigue interference in patients with advanced lung cancer and caregiving burden: protocol for a pilot randomised controlled trial
Authors: Li Huiyuan , Wong Cho Lee , Jin Xiaohuan , Wang Nina , Shi Zhengkun 
Published: July 2024

IntroductionCancer-related fatigue is common in patients with advanced lung cancer. It not only interferes with patients’ health-related quality of life, but also increases the caregiving burden of their caregivers. Acceptance and commitment therapy is emerging as a novel way to advocate accepting negative experiences and taking effective actions based on their own values to help patients commit meaningful actions in the course of cancer diseases. This trial aims to test the feasibility, acceptability and preliminary effects of acceptance and commitment therapy for fatigue interference in patients with advanced lung cancer and the caregiver burden.Method and analysisA two-arm, assessor-blind pilot randomised controlled trial will be conducted. A total of 40 advanced lung cancer patient–caregiver dyads, who live in rural areas, will be recruited from a university-affiliated hospital in central China. The participants will be randomised to receive an online six-session acceptance and commitment therapy (i.e. involving metaphors, experiential exercises and mindfulness exercises facilitated by virtual reality technology) plus health education (intervention group, n=20) or health education (control group, n=20). Outcomes will be measured at baseline and 1 week postintervention. The primary outcomes are study feasibility (i.e. eligibility rate, recruitment rate, attrition rate and adherence rate), fatigue interference and caregiver burden. The secondary outcomes are health-related quality of life, meaning in life, psychological flexibility and mindful attention. Semistructured interviews will be conducted to explore the feasibility and experiences of the intervention in a subsample of 10 participants from the intervention group.Ethics and disseminationThis study has been approved by the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee (CREC Ref. No. 2023.030) and the Medical Ethics Committee of Xiangya Hospital Central South University (No. 202305336). The findings will be disseminated in peer-reviewed journals and through local or international conference presentations.Trial registration numberNCT05885984.
Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma
Authors: Lake Jessica A , Woods Elena , Hoffmeyer Eric , Schaller Kristin L , Cruz-Cruz Joselyn , Fernandez Joseph , Tufa Dejene , Kooiman Benjamin , Hall Spencer C , Jones Dallas , Hayashi Masanori , Verneris Michael R 
Published: July 2024

BackgroundAdvances in pediatric oncology have occurred for some cancers; however, new therapies for sarcoma have been inadequate. Cellular immunotherapy using chimeric antigen receptor (CAR) T cells has shown dramatic benefits in leukemia, lymphoma, and multiple myeloma but has been far less successful in pediatric solid tumors such as rhabdomyosarcoma (RMS) and osteosarcoma (OS). Balancing issues of “on-target, off-tumor toxicity”, investigators have identified B7-H3 as a broadly expressed tumor antigen with otherwise restricted expression on normal tissues. We hypothesized that rapid homing via a chemokine receptor and CAR engagement through B7-H3 would enhance CAR T cell efficacy in solid tumors.MethodsWe generated B7-H3 CAR T cells that also express the Interleukin-8 (IL-8) receptor, CXCR2. Cytokine production, flow cytometry, Seahorse assays and RNA sequencing were used to compare the B7-H3 CXCR2 (BC2) CAR T cells with B7-H3 CAR T cells. We developed an IL-8 overexpressing human RMS mouse model to test homing and cytotoxicity in vivo.ResultsWe demonstrate that IL-8 is expressed by RMS and OS and expression significantly increases after radiation. Overexpression of an IL-8 receptor, CXCR2, on B7-H3 CAR T cells enhances homing into IL-8 expressing tumors, augments T cell metabolism and leads to significant tumor regression.ConclusionThese findings warrant further investigation into the use of BC2 CAR T cells as a treatment for patients with RMS, OS and other B7-H3-expressing, IL-8 producing solid tumors.
Horndeski-like gravity perturbation induced by large-magnitude earthquake
Authors: Koorambas Elias 
Published: July 2024

AbstractWe hypothesis that large earthquakes generate Horndeski-like Gravitational Wave (GW). We find that such a Horndeski-like GW propagates with the speed of sound. The sound waves generated by an earthquake make a local and temporal change to the Earth’s diagravitational medium; therefore, they modify the GW speed in a standard, Alternative-Theory-of-Gravity (ATG) sense. The quantum of the Horndeski-like GW is a massless scalar quasiparticle and cannot exist outside of the propagation region of the P-field. The Horndeski-like GW may be detectable by future GW detectors with a sensitivity of 10–15 $$\hbox {Hz}^{{-1/2}}$$

Hz

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in the region of 0.1–1 Hz.
Model-Mediated Teleoperation: An Operator-Centric Perspective
Authors: van der Walt Christophe , Falcone Sara , van Erp Jan , Stramigioli Stefano , Dresscher Douwe 
Published: July 2024

Abstract
Haptic teleoperation is a means of dexterously manipulating environments wherein a human operator can be situated several hundreds of kilometers away from the site of manipulation. Time delays between the local and remote sites pose problems for the user experience. Model-mediated teleoperation addresses these problems, but assumes a sufficiently representative model of the operator and of the environment. When applied to complex environments, this model becomes difficult to work with. A solution to this difficulty lies in the fact that human perceptual capabilities are limited. So too, possibly, is the amount of feedback needed in order to accomplish tasks effectively. In this work, we review information on human perception of the environmental properties involved in environmental perception (inertia, friction, roughness, compliance, and geometry). Moreover, we detail how these properties can be modeled. Finally, we propose some open questions that are relevant in understanding the link between the environment presented to the operator and their effectiveness at accomplishing tasks.
“The Most Fantastic Thing is Coming Here as an Individual and Going to Bed as Part of a Group”: Participants’ Experiences From a Residential Course, for People With Advanced Cancer
Authors: Gärtner Henriette Søby , Blix Bodil H. , Raunkiær Mette , Timm Helle 
Published: July 2024

People who suffer from advanced cancer may experience a loss of ability to participate in everyday life and meaningful activities, challenging their sense of identity and social relations. Social support in patient-to-patient interactions and the sharing of experiences with people in similar situations may help alleviate distress. This article is based on an ethnographic field study carried out in relation to three residential narrative courses, which included 36 persons with advanced cancer. In this study, we aimed to explore whether the courses were perceived as significant by the participants and, if so, in what ways. The field work included 185 hr of observations, six focus group interviews and nine individual interviews. The data were analyzed using an abductive thematic approach. Our findings indicate that the residential courses were generally experienced as meaningful and that in particular the setting, the community, and gaining hope were experienced as significant.
Hydrothermal aging and soil biodegradation characteristics of biopolymer based sustainable composites
Authors: Santhosh Kumar Karri , Kaushik Deepak , Singh Inderdeep 
Published: July 2024

The current research endeavor examines the water absorption (in-service life) and soil biodegradation (end-of-the-service life) behavior of short sisal fiber (SF) reinforced poly (lactic acid) (PLA) and bio-based poly (butylene succinate) (bio PBS) composites. Samples were fabricated by extrusion-injection molding with varying sisal fiber loading of 10, 20, and 30 wt%. The water absorption test was conducted in distilled water at three distinct temperatures (5, 25, and 45 °C) for 336 h. The sorption behavior of composites was studied experimentally, and detailed diffusion kinetic behavior is discussed using Fickian diffusion models. The impact of fiber content and hydrothermal temperature on water diffusion and maximum water absorption was investigated in detail. A soil burial test was conducted in local farmland soil for 60 days to determine the influence of fiber content on the biodegradation characteristics of composites. After exposure to hydrothermal aging, it was concluded that fiber loading was most significant in affecting the maximum percentage of water absorption, whereas hydrothermal temperature was more relevant for higher water diffusion. Soil burial tests showed that SF/bioPBS composites degraded quickly as compared to PLA composites. Overall, composites made with bio PBS have shown an expected response than PLA composites in terms of water absorption and soil biodegradation.
Subclinical hypothyroidism and metabolic syndrome in psychiatric patients: A systematic literature review and meta-analysis
Authors: Aung The The , Wah Win , Chakraborti Arnob , Garg Vikas 
Published: July 2024

Objective The systematic review evaluated the association of subclinical hypothyroidism (SCH) with metabolic syndrome (MetS) and specific MetS components in people with major psychiatric disorders. Methods A systematic review and meta-analysis was conducted to evaluate the association of SCH with MetS and its components in people with major psychiatric conditions. Results Five studies incorporating 24,158 participants met the inclusion criteria. All five studies comprised patients with depression and/or anxiety. Three studies incorporating 3365 participants were suitable for the meta-analysis. The pooled Odds Ratio (OR) of MetS was 3.46 (95% Confidence Interval/CI = 1.39–8.62) in major depressive disorder (MDD) and anxiety disorders patients with concurrent SCH compared to those without SCH. Meta-analysis showed a significant positive association between SCH and high body mass index (OR = 2.58, 95%CI = 1.33–5.01), high fasting plasma glucose (OR = 3.05, 95%CI = 1.79–5.18) and low high-density lipoprotein cholesterol (OR = 2.30, 95%CI = 1.82–2.92). Conclusions These findings suggest a significant positive association between MetS and SCH in people with MDD and anxiety disorders. This review informed the clinical implications of MetS in MDD with comorbid SCH and the importance of early diagnosis and treatment for SCH and MetS in psychiatric patients.
Real-world effectiveness of cladribine as an escalation strategy for MS: Insights from the Czech nationwide ReMuS registry
Authors: Potuznik Pavel , Drahota Jiri , Horakova Dana , Peterka Marek , Mazouchova Aneta , Matyas David , Pavelek Zbysek , Vachova Marta , Recmanova Eva , Stetkarova Ivana , Libertinova Jana , Mares Jan , Stourac Pavel , Grunermelova Marketa , Martinkova Alena , Adamkova Jana , Hradilek Pavel , Ampapa Radek , Dufek Michal , Kubala Havrdova Eva , Stastna Dominika 
Published: July 2024

Background Cladribine, a selective immune reconstitution therapy, is approved for the treatment of adult patients with highly active multiple sclerosis (MS). Objectives Provide experience with cladribine therapy in a real-world setting. Methods This is a registry-based retrospective observational cohort study. First, using data from the Czech nationwide registry ReMuS, we analysed patients who initiated cladribine from September 1, 2018 to December 31, 2021. Second, we analysed a subgroup of patients who initiated cladribine between September 1, 2018 to June 30, 2020, thus possessing a follow-up period of at least 2 years. We evaluated demographic and MS characteristics including disease-modifying therapies (DMTs) before and after cladribine administration, relapses, Expanded Disability Status Scale (EDSS), and adherence. Results In total, 617 patients (335 with follow-up of at least 2 years) started cladribine therapy in the study period (mean age 37.0, mean disease duration 8.4 years, 74.1% females). In most cases, cladribine was administered as a second-line drug, a total of 80.7% had been escalated from a platform DMT. During 2 years before cladribine initiation, the average annualised relapse rate (ARR) was .67. Following cladribine initiation, the ARR decreased to .28 in the first year and .22 in the second year. Overall, across the entire two-year treatment period, 69.0% of patients were relapse-free and the average ARR was .25. As for EDSS development, the median baseline EDSS was 2.5 and remained stable even after 24 months. The adherence to treatment ranged of around 90%. Conclusion This nationwide study confirms the efficacy of cladribine in real-world settings, especially in patients who are not treatment-naïve. In addition, the study shows an exceptionally high adherence rate, a finding that underscores the invaluable role of cladribine, but also the value of registry-based studies in capturing real-world clinical practice.
Pronoun interpretation in intermediate-advanced L2 English speakers: L2 to L1 cross-linguistic effects
Authors: Contemori Carla , Mossman Sabrina 
Published: July 2024

Aims and objectives: L2 learners who speak a null subject (L1 Spanish) and a non-null subject language (L2 English) may experience cross-linguistic interference from the L2 on L1 pronoun interpretation. In this study, we test pronoun interpretation in the L1 and L2 of adult learners, in comparison with two groups of monolingual speakers, to assess if L1 pronoun interpretation can change as a result of L2 acquisition at intermediate-advanced levels of L2 proficiency and in the absence of long L2 immersion. Methodology: A group of L2 English speakers (L1 Spanish) participated in two offline sentence comprehension tasks where they interpreted pronouns in the L1 and L2. The results are compared with English and Spanish monolingual speakers. Data and analysis: We find that adult English learners comprehend pronouns in their L1 (Spanish) differently than Spanish monolingual speakers, demonstrating a strong subject bias for interpreting null and overt pronouns. In addition, we show that pronoun interpretation patterns acquired in the L2 explain the changes to L1 interpretation biases. Conclusions: The results of this study significantly advance the understanding of the factors that contribute to bilingual language comprehension, showing the permeability of the L1 comprehension system at the discourse level as soon as the L2 sets in.
The role of hypertension in the relationship between leisure screen time, physical activity and migraine: a 2-sample Mendelian randomization study
Authors: Gan Quan , Song Enfeng , Zhang Lily , Zhou Yanjie , Wang Lintao , Shan Zhengming , Liang Jingjing , Fan Shanghua , Pan Songqing , Cao Kegang , Xiao Zheman 
Published: July 2024

Abstract
Background
The relationship between lifestyle and migraine is complex, as it remains uncertain which specific lifestyle factors play the most prominent role in the development of migraine, or which modifiable metabolic traits serve as mediators in establishing causality.

Methods
Independent genetic variants strongly associated with 20 lifestyle factors were selected as instrumental variables from corresponding genome-wide association studies (GWASs). Summary-level data for migraine were obtained from the FinnGen consortium (18,477 cases and 287,837 controls) as a discovery set and the GWAS meta-analysis data (26,052 cases and 487,214 controls) as a replication set. Estimates derived from the two datasets were combined using fixed-effects meta-analysis. Two-step univariable MR (UVMR) and multivariable Mendelian randomization (MVMR) analyses were conducted to evaluate 19 potential mediators of association and determine the proportions of these mediators.

Results
The combined effect of inverse variance weighted revealed that a one standard deviation (SD) increase in genetically predicted Leisure screen time (LST) was associated with a 27.7% increase (95% CI: 1.14–1.44) in migraine risk, while Moderate or/and vigorous physical activity (MVPA) was associated with a 26.9% decrease (95% CI: 0.61–0.87) in migraine risk. The results of the mediation analysis indicated that out of the 19 modifiable metabolic risk factors examined, hypertension explains 24.81% of the relationship between LST and the risk of experiencing migraine. Furthermore, hypertension and diastolic blood pressure (DBP) partially weaken the association between MVPA and migraines, mediating 4.86% and 4.66% respectively.

Conclusion
Our research findings indicated that both LST and MVPA in lifestyle have independent causal effects on migraine. Additionally, we have identified that hypertension and DBP play a mediating role in the causal pathway between these two factors and migraine.
Developing benzylisoquinoline alkaloid-enriched opium poppy via CRISPR-directed genome editing: A review
Authors: Aghaali Zahra , Naghavi Mohammad Reza 
Published: July 2024

AbstractAmong plant-derived secondary metabolites are benzylisoquinoline alkaloids (BIAs) that play a vital role in medicine. The most conspicuous BIAs frequently found in opium poppy are morphine, codeine, thebaine, papaverine, sanguinarine, and noscapine. BIAs have provided abundant clinically useful drugs used in the treatment of various diseases and ailments With an increasing demand for these herbal remedies, genetic improvement of poppy plants appears to be essential to live up to the expectations of the pharmaceutical industry. With the advent of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated9 (Cas9), the field of metabolic engineering has undergone a paradigm shift in its approach due to its appealing attributes, such as the transgene-free editing capability, precision, selectivity, robustness, and versatility. The potentiality of the CRISPR system for manipulating metabolic pathways in opium poppy was demonstrated, but further investigations regarding the use of CRISPR in BIA pathway engineering should be undertaken to develop opium poppy into a bioreactor synthesizing BIAs at the industrial-scale levels. In this regard, the recruitment of RNA-guided genome editing for knocking out miRNAs, flower responsible genes, genes involved in competitive pathways, and base editing are described. The approaches presented here have never been suggested or applied in opium poppy so far.
PPGV: a comprehensive database of peach population genome variation
Authors: An Yanlin , Ban Qiuyan , Liu Li , Zhang Feng , Yu Shirui , Jing Tingting , Zhao Shiqi 
Published: July 2024

AbstractPeach tree is one of the most important fruit trees in the world, and it has been cultivated for more than 7,500 years. In recent years, the genome and population resequencing of peach trees have been published continuously, which has effectively promoted the research of peach tree genetics and breeding. In order to promote the further mining and utilization of these data, we integrated and constructed a comprehensive peach genome and variation database (PPGV, http://peachtree.work/home). The PPGV contains 10 sets of published peach tree genome data, as well as genomic variation information for 1,378 peach tree samples (the resequencing data of 1,378 samples were aligned with the high-quality genomes of Lovell, CN14 and Chinesecling, respectively, for mutation detection). A variety of useful and flexible tools, such as BLAST, Gene ID Convert, KEGG/GO Enrichment, Primer Design and Gene function, were also specially designed for searching data and assisting in breeding.
Setting reasonable goals for kidney transplant referral among dialysis facilities
Authors: Harding Jessica L. , Dixon Meredith A. , Di Mengyu , Hogan Julien , Pastan Stephen O. , Patzer Rachel E. 
Published: July 2024

Abstract
Background
Determining whether a patient is eligible for kidney transplantation is complex. In this study, we estimate what proportion of patients with end-stage kidney disease (ESKD) might have been suitable candidates for kidney transplantation but were not referred.

Methods
We identified 43,952 people initiating dialysis for kidney failure between 2012 and 2017 in the states of Georgia, North Carolina, or South Carolina from the United States Renal Data System and linked to the Early-Steps to Transplant Access Registry to obtain data on referral and waitlisting up until December 2020. We identified ‘good transplant candidates’ as those who were waitlisted within 2-years of referral, among all patients referred within 1-year of dialysis initiation. Using propensity score cut-offs, logistic regression, and area under the curve (AUC), we then estimated the proportion of individuals who may have been good transplant candidates, but were not referred.

Results
Overall, 42.6% of incident dialysis patients were referred within one year and among them, 32.9% were waitlisted within 2 years of referral. Our model had reasonably good discrimination for identifying good transplant candidates with an AUC of 0.70 (95%CI 0.69–0.71), sensitivity of 0.68 and specificity of 0.61. Overall, 25% of individuals not referred for transplant may have been ‘good’ transplant candidates. Adding these patients to the existing 18,725 referred patients would increase the proportion of incident ESKD patients being referred within one year from 42.6% to 57.2% (a ~ 14.6% increase).

Conclusions
In this study, we show that a significant proportion of potentially good transplant candidates are not being referred for transplant. A ~ 14% increase in the proportion of patients being referred from dialysis facilities is both a meaningful and realistic goal and could lead to more qualified patients being referred and subsequently waitlisted for a lifesaving transplant.
Clinical features and treatment of apoplectic intratumoral hemorrhage of glioma
Authors: Zhou Jia-hua , Wang Chao , Yang Di , Wu Ying-xi , Feng Da-yun , Qin Huaizhou , Wang Ju-lei , Wei Ming-hao 
Published: July 2024

Abstract
Objective
The primary objective of this study was to explore the clinical characteristics of apoplectic intratumoral hemorrhage in gliomas and offer insights for improving the diagnosis and treatment of this disease.

Methods
We analyzed the clinical data of 35 patients with glioma and hemorrhage. There were eight cases of multiple cerebral lobe involvement, and 22 cases involved a single lobe. Twenty-one patients had a preoperative Glasgow Coma Scale (GCS) score of ≥ 9 and had a craniotomy with tumor resection and hematoma evacuation after undergoing preoperative preparation. A total of 14 patients with GCS < 9, including one with thalamic hemorrhage breaking into the ventricles and acute obstructive hydrocephalus, underwent craniotomy for tumor resection after external ventricular drainage (EVD). One patient had combined thrombocytopenia, which was surgically treated after platelet levels were normalized through transfusion. The remaining 12 patients received immediate intervention in the form of craniotomy hematoma evacuation and tumor resection.

Results
We performed subtotal resection on three tumors of thalamic origin and two tumors of corpus callosum origin, but we were able to successfully resect all the tumors in other locations that were gross total resection Pathology results showed that 71.43% of cases accounted for WHO-grade 4 tumors. Among the 21 patients with a GCS score of ≥ 9, two died perioperatively. Fourteen patients had a GCS score < 9, of which eight patients died perioperatively.

Conclusions
Patients with a preoperative GCS score ≥ 9 who underwent subemergency surgery and received aggressive treatment showed a reasonable prognosis. We found their long-term outcomes to be correlated with the pathology findings. On the other hand, patients with a preoperative GCS score < 9 required emergency treatment and had a high perioperative mortality rate.