bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germacrone: A Multi-targeting Sesquiterpene with Promising Anti-cancer and Chronic Disease Applications
Authors: Tailor Navin Kumar , Grewal Ajmer Singh , Deswal Geeta , Dhingra Ashwani Kumar 
Published: August 2024

Background:
Germacrone, a naturally occurring active compound found in essential oils extracted
from medicinal plants within the Zingiberaceae family, has garnered attention for its potential therapeutic applications.
Extensive research has highlighted its multi-targeting capabilities, positioning it as a promising treatment
for various chronic diseases, including cancer, cardiovascular conditions, and neurodegenerative disorders like
Alzheimer's disease.

Objective:
This review aims to provide a comprehensive overview of germacrone as a scaffold for developing
multi-targeting drugs with therapeutic potential against a range of chronic disorders. The study delves into the
molecular mechanisms that underlie the therapeutic effects of germacrone and explores its potential targets, including
NF-κB, PI3K/AKT/mTOR, p53, JAK/STAT, caspase, apoptosis, and autophagy induction.

Methods:
A systematic review of literature databases was conducted to gather relevant studies on germacrone and
its therapeutic applications. The molecular mechanisms and potential targets of germacrone were examined to
elucidate its multi-targeting capabilities.

Results:
Germacrone exhibits significant potential in the management of chronic diseases, with demonstrated
effects on various cellular pathways. The review highlights its impact on NF-κB, PI3K/AKT/mTOR, p53,
JAK/STAT, caspase, apoptosis, and autophagy induction, showcasing its versatility in targeting multiple pathways
associated with chronic conditions. Germacrone has emerged as a promising candidate for the treatment of
diverse chronic diseases. The understanding of its multi-targeting capabilities, coupled with its natural origin,
positions it as a valuable scaffold for developing therapeutics.

Conclusion::
The exploration of germacrone as a structural framework for multi-targeting drugs offers a potential
avenue to enhance efficacy while minimizing potential side effects. Further research and clinical trials are warranted
to validate the therapeutic potential of germacrone in diverse medical contexts.
Relationships of Prodiginins Mechanisms and Molecular Structures to their Antiproliferative Effects
Authors: Ayoub El Abbassi , Azoubi Zineb , Nadia Zougagh , Assia Mouslim , Mohammed Menggad 
Published: August 2024

:
The Prodiginins (PGs) natural pigments are secondary metabolites produced by a broad spectrum of
gram-negative and gram-positive bacteria, notably by species within the Serratia and Streptomyces genera. These
compounds exhibit diverse and potent biological activities, including anticancer, immunosuppressive, antimicrobial,
antimalarial, and antiviral effects. Structurally, PGs share a common tripyrrolic core but possess variable
side chains and undergo cyclization, resulting in structural diversity. Studies have investigated their antiproliferative
effects on various cancer cell lines, with some PGs advancing to clinical trials for cancer treatment. This
review aims to illuminate the molecular mechanisms underlying PG-induced apoptosis in cancer cells and explore
the structure-activity relationships pertinent to their anticancer properties. Such insights may serve as a foundation
for further research in anticancer drug development, potentially leading to the creation of novel, targeted
therapies based on PGs or their derivatives.
The Impact of Community-based Mental Health Interventions on Mental Disorders
Authors: Noronha Flavia Sharlet , Jose Tessy Treesa , George Linu Sara , Bhandary Rajeshkrishna , Praharaj Samir 
Published: August 2024

Introduction:
Common Mental Disorders (CMD) cause significant impairment
in socio-occupational functioning, leading to dreadful socio-economic consequences on the
individual, family, and society. Even though mental illness is prevalent worldwide, the
public health burden of mental illness seems to be the highest in low- and middle-income
countries (LMICs). In these countries, lack of access to essential mental health services has
also led to a significant treatment gap in psychiatric disorders. In such a situation, reaching
out to the community and utilizing community-based resources to decentralize mental
health care is essential.

Objective:
The aim of this narrative review was to appraise the impact of community-based
mental health interventions on CMD. This review also highlights the impact of the rightsbased
approach in mental health care and the psychosocial determinants of mental health.

Methods:
A thorough search of databases, such as PubMed/Medline, CINHAL, and Scopus,
was done to gather articles published between January 2001 and July 2023. Studies
answering the central theme of the review, such as the trends and existing mental health
services in the community and their impact on CMD, were included in the review. The
relevant articles were analyzed in detail.

Results::
Involvement of people at the grassroots level through peer support programs or in
recovery camps, addressing the social determinants like poverty, housing, and unemployment,
and a rights-based approach in every mental health service were found to be beneficial
and effective in running community mental health services. These approaches are the
need of the hour and are well accepted by the people in the community.

Conclusion:
In order to overcome the treatment gap in LMICs, a well-utilized community
mental health service is the only way out. The allocation of adequate funds by policymakers,
the development of infrastructure, and investment in manpower need to be scaled up
tremendously.
Summary Measure of Health-Related Quality of Life and Its Related Factors Based on the Chinese Version of the Core Healthy Days Measures: Cross-Sectional Study
Authors: Shi Yulin , Wang Baohua , Zhao Jian , Wang Chunping , Li Ning , Chen Min , Wan Xia 
Published: August 2024

Abstract

Background
The core Healthy Days measures were used to track the population-level health status in the China Chronic Disease and Risk Factor Surveillance; however, they were not easily combined to create a summary of the overall health-related quality of life (HRQOL), limiting this indicator’s use.

Objective
This study aims to develop a summary score based on the Chinese version of the core Healthy Days measures (HRQOL-5) and apply it to estimate HRQOL and its determinants in a Chinese population.

Methods
From November 2018 to May 2019, a multistage stratified cluster survey was conducted to examine population health status and behavioral risk factors among the resident population older than 15 years in Weifang City, Shandong Province, China. Both exploratory factor analyses and confirmatory factor analyses were performed to reveal the underlying latent construct of HRQOL-5 and then to quantify the overall HRQOL by calculating its summary score. Tobit regression models were finally carried out to identify the influencing factors of the summary score.

Results
A total of 26,269 participants (male: n=13,571, 51.7%; mean age 55.9, SD 14.9 years) were included in this study. A total of 71% (n=18,663) of respondents reported that they had excellent or very good general health. One summary factor was extracted to capture overall HRQOL using exploratory factor analysis. The confirmatory factor analysis further confirmed this one-factor model (Tucker-Lewis index, comparative fit index, and goodness-of-fit index >0.90; root mean square error of approximation 0.02). Multivariate Tobit regression analysis showed that age (β=–0.06), educational attainments (primary school: β=0.72; junior middle school: β=1.46; senior middle school or more: β=2.58), average income (≥¥30,000 [US $4200]: β=0.69), physical activity (β=0.75), alcohol use (β=0.46), self-reported disease (β=−6.36), and self-reported injury (β=–5.00) were the major influencing factors on the summary score of the HRQOL-5.

Conclusions
This study constructs a summary score from the HRQOL-5, providing a comprehensive representation of population-level HRQOL. Differences in summary scores of different subpopulations may help set priorities for health planning in China to improve population HRQOL.
Pediatric Sedation Assessment and Management System (PSAMS) for Pediatric Sedation in China: Development and Implementation Report
Authors: Zhu Ziyu , Liu Lan , Du Min , Ye Mao , Xu Ximing , Xu Ying 
Published: August 2024

Abstract

Background
Recently, the growing demand for pediatric sedation services outside the operating room has imposed a heavy burden on pediatric centers in China. There is an urgent need to develop a novel system for improved sedation services.

Objective
This study aimed to develop and implement a computerized system, the Pediatric Sedation Assessment and Management System (PSAMS), to streamline pediatric sedation services at a major children’s hospital in Southwest China.

Methods
PSAMS was designed to reflect the actual workflow of pediatric sedation. It consists of 3 main components: server-hosted software; client applications on tablets and computers; and specialized devices like gun-type scanners, desktop label printers, and pulse oximeters. With the participation of a multidisciplinary team, PSAMS was developed and refined during its application in the sedation process. This study analyzed data from the first 2 years after the system’s deployment.

Implementation (Results)
From January 2020 to December 2021, a total of 127,325 sedations were performed on 85,281 patients using the PSAMS database. Besides basic variables imported from Hospital Information Systems (HIS), the PSAMS database currently contains 33 additional variables that capture comprehensive information from presedation assessment to postprocedural recovery. The recorded data from PSAMS indicates a one-time sedation success rate of 97.1% (50,752/52,282) in 2020 and 97.5% (73,184/75,043) in 2021. The observed adverse events rate was 3.5% (95% CI 3.4%‐3.7%) in 2020 and 2.8% (95% CI 2.7%-2.9%) in 2021.

Conclusions
PSAMS streamlined the entire sedation workflow, reduced the burden of data collection, and laid a foundation for future cooperation of multiple pediatric health care centers.
Association Between Particulate Matter Exposure and Preterm Birth in Women With Abnormal Preconception Thyrotropin Levels: Large Cohort Study
Authors: Xu Ting , Ni Haobo , Cai Xiaoyan , Dai Tingting , Wang Lingxi , Xiao Lina , Zeng Qinghui , Yu Xiaolin , Han Lu , Guo Pi 
Published: August 2024

Abstract

Background
Prior research has linked exposure to particulate matter with an aerodynamic diameter of ≤2.5 μm (PM2.5) with preterm birth (PTB). However, the modulating effect of preconception thyroid stimulating hormone (TSH) levels on the relationship between PM2.5 exposure and PTB has not been investigated.

Objective
This study aimed to assess whether preconception TSH levels modulate the impact of PM2.5 exposure on PTB.

Methods
This cohort study was conducted in Guangdong, China, as a part of the National Free Pre-Pregnancy Checkups Project. PM2.5 exposure was estimated by using the inverse distance weighting method. To investigate the moderating effects of TSH levels on trimester-specific PM2.5 exposure and PTB, we used the Cox proportional hazards model. Additionally, to identify the susceptible exposure windows for weekly specific PM2.5 exposure and PTB, we built distributed lag models incorporating Cox proportional hazards models.

Results
A total of 633,516 women who delivered between January 1, 2014, to December 31, 2019, were included. In total, 34,081 (5.4%) of them had abnormal preconception TSH levels. During the entire pregnancy, each 10-μg/m3 increase in PM2.5 was linked to elevated risks of PTB (hazard ratio [HR] 1.559, 95% CI 1.390‐1.748), early PTB (HR 1.559, 95% CI 1.227‐1.980), and late PTB (HR 1.571, 95% CI 1.379‐1.791) among women with abnormal TSH levels. For women with normal preconception TSH levels, PM2.5 exposure during the entire pregnancy was positively associated with the risk of PTB (HR 1.345, 95% CI 1.307‐1.385), early PTB (HR 1.203, 95% CI 1.126‐1.285), and late PTB (HR 1.386, 95% CI 1.342‐1432). The critical susceptible exposure windows were the 3rd-13th and 28th-35th gestational weeks for women with abnormal preconception TSH levels, compared to the 1st-13th and 21st-35th gestational weeks for those with normal preconception TSH levels.

Conclusions
PM2.5 exposure was linked with a higher PTB risk, particularly in women with abnormal preconception TSH levels. PM2.5 exposure appears to have a greater effect on pregnant women who are in the early or late stages of pregnancy.
Contract Staff Acceptance Selection Using Simple Additive Weighting (SAW) Method
Authors: Kusumawati Dewi , Grace Diana , Rusydi Muh , Rahmawaty  , Rasmita Ngemba Hajra , Hidayat Nurul , Rahmawati Siti 
Published: August 2024

Introduction : Technology is a supporter in making decisions made by a top-level leader. Good decision making will produce a good decision. An example of decision making is the determination of an honorary employment appointment at an agency. In some areas, there are still various offices or government agencies whose recruitment process has not been carried out professionally, but still in the usual ways in the environment such as friendship or family relations. This research designed a web-based decision support system application using SAW method to support the labor selection process at the Class II Agricultural Quarantine Center in Palu. The type of research conducted is qualitative descriptive study. The system development method used in this research is Waterfall development. Waterfall method is the workmanship of a system carried out sequentially or linearly. The analytical method used is Simple Additive Weighting (SAW). This method used because the basic concept of SAW method is to find a weighted sum of the performance ratings on each alternative of all attributes. The programming language used is PHP, while the database used is MySQL. The method used to test this system is black box testing method. Based on manual calculations as a comparison with the calculation of the system built, it can be obtained same results for its value. In addition, the results of ranking was obtained, where the alternative manual calculation that has the highest value is Fadila with a vector value of 1.00.
Studi In-Vitro Efektifitas Grain Kefir dengan Kombinasi Sorbitol Terhadap Pertumbuhan Streptococcus mutans
Authors: Sutanti Viranda , Rachmawati Yuanita Lely , Putra Bintang Vallentino Nugraha , Pangestu Herlambang 
Published: August 2024

Karies gigi adalah penyakit kronis jaringan keras gigi yang disebabkan oleh Streptococcus mutans (S.mutans). Berbagai metode termasuk aplikasi pasta gigi, senyawa antibakteri dan obat kumur yang mengandung fluoride bersama dengan penggunaan pemanis yang tidak dapat difermentasi seperti sorbitol telah disarankan untuk mengurangi aktivitas bakteri ini. Pada studi ekologi mulut telah mengkonfirmasi efektifitas bakteri probiotik dalam mengurangi jumlah S. mutans. Grain kefir merupakan salah satu produk probiotik. Tujuan penelitian ini adalah untuk melihat efektifitas grain kefir murni dan kombinasi dengan sorbitol terhadap pertumbuhan S. mutans secara in vitro. Penelitian dilakukan di laboratorium Biologi Oral Fakultas Kedokteran Gigi Universitas Brawijaya pada bulan Januari-Februari 2023. Dilakukan uji KHM (Konsentrasi Hambat Minimum) menggunakan uji tabung dan KBM (Konsentrasi Bakterisidal Minimum) menggunakan colony counter. Penentuan konstrasi perlakukan diawali dengan uji pendahuluan grain kefir murni konsentrasi 3,125% dan 6,25%, 12,5%, 25%, 50% dan 100%. Nilai KHM grain kefir murni uji pendahuluan terhadap S.mutans pada konsentrasi 12,5%. Pada konsentrasi perlakuan didapatkan nilai KHM grain kefir murni adalah 15% dan kombinasi grain kefir-sorbitol terhadap S.mutans yaitu pada konsentrasi 12,5%. Nilai KBM grain kefir murni didapatkan pada konsentrasi 15% dan kombinasi grain kefir-sorbitol pada konsentrasi 12,5%. Kombinasi grain kefir-sorbitol dapat menurunkan pertumbuhan S. mutans pada konsentrasi 12,5%.
Adenoma Pleomorfik di Tonsil: Kasus Langka
Authors: Pelealu Olivia Claudia , Hamida Deta 
Published: August 2024

Adenoma pleomorfik adalah gambaran tumor jinak secara histopatologis yang dapat ditemukan di kelenjar liur, kelenjar parotis, kelenjar submandibular, kelenjar palatina minor dan kelenjar bukal minor. Pada makalah ini dilaporkan kasus adenoma pleomorfik di tonsil pada perempuan berusia 38 tahun dengan keluhan rasa tersumbat di tenggorok sejak 1 tahun lalu. Pasien sulit menelan tanpa disertai rasa nyeri saat menelan. Demam, batuk, flu, keluar darah dari telinga, hidung, mulut dan gangguan pendengaran disangkal. Pada pemeriksaan orofaring didapatkan T4/T3, hingga menutupi uvula. Pada pemeriksaan leher, tidak tampak pembesaran dan pada saat palpasi leher tidak teraba pembesaran kelenjar getah bening. Dilakukan biopsi jaringan di tonsil dengan hasil adenoma pleomorfik dan tidak ada keganasan sehingga dilakukan tonsilektomi pada kedua tonsil. Pengangkatan kedua tonsil diharapkan dapat mencegah rekurensi dan diferensiasi ke arah keganasan. Dengan laporan kasus ini diharapkan kewaspadaan dokter pada pembesaran tonsil.
Inkontinensia Urin pada Perempuan
Authors: Djusad Suskhan 
Published: August 2024

Inkontinensia Urin (IU) merupakan kondisi pasien yang tidak dapat menahan keluarnya urin atau keluarnya urin secara involunter. Faktor risiko IU adalah usia, status hormonal dan menopause, obesitas, diabetes melitus tipe 2, PPOK, merokok, persalinan per vaginam, ras, serta riwayat keluarga/genetik. Jenis IU dapat dibedakan menjadi transien dan murni; IU murni dibagi menjadi tipe tekanan, desakan, overflow, dan kontinu. Diagnosis IU ditegakkan berdasarkan anamnesis, pemeriksaan fisik umum dan khusus, voiding diary, dan pemeriksaan penunjang. Tata laksana meliputi terapi konservatif dengan latihan Kegel dan pemasangan pesarium serta pembedahan antara lain dengan prosedur kolporafi anterior atau sling pubovaginal. Program intervensi harus menargetkan pasien dan suaminya agar menyesuaikan diri dengan kondisi sehingga dapatmeningkatkan kualitas hidup secara efektif.
Perintah Komandan Terhadap Bawahan dalam Kasus Penembakan Polisi Duren Tiga Perspektif Filsafat Etika Immanuel Kant
Authors: Fitri Nur Annisa , Arman  
Published: August 2024

Richard Eliezer berstatus sebagai justice collaborator mengenai kasus pembunuhan Brigadir Yosua, ia menerangkan bahwa penembakan ini sudah direncanakan oleh terdakwa Ferdy Sambo, sebagaimana keterangannya dalam persidangan. Namun, setelah mereka berstatus tersangka, Ferdy Sambo menolak dengan tegas mengenai penjelasan Richard, pembunuhan ini tidak direncanakan, bahkan ia mengatakan pada saat terjadi penembakan, ia memerintahkan Richard untuk menghajar bukan menembak. Adanya dua versi cerita yang berbeda memberikan sudut pandang bahwa dalam penelitian ini melihat ke dua arah keterangan yang berbeda. Pada penelitian ini penulis akan menganalisis terkait perintah atasan terhadap bawahan dengan menggunakan etika Immanuel Kant. Adapun metode yang digunakan dalam penelitian ini, yaitu kualitatif deskriptif, dengan mengumpulkan berbagai macam data sekunder yang relevan dengan permasalahan. Penelitian ini menggunakan studi pustaka. Adapun hasilnya, yakni pandangan Kant mengenai etika yang sesuai dengan kasus ini adalah personal otonomi (kebebasan manusIa), dalam teori tersebut dijelaskan bahwa semua manusia di muka bumi harus otonom dan bebas termasuk Richard Eliezer, tetapi mereka dibingkai oleh satuan dalam hal ini Polri. Ketaatan bawahan terhadap atasan selalu ada dalam kebudayaan Polisi, sehingga sering terdengar kalimat siap Komandan. Dengan demikian, membuat bawahan sulit untuk melakukan penolakan terhadap atasan.
Pendidikan Holistik: Perspektif Filsafat Sufisme dalam Pengembangan Kurikulum
Authors: Maghfiroh Ana Minniswatil , Akhyak Akhyak 
Published: August 2024

Pendidikan Holistik merupakan pendekatan pembelajaran secara keseluruhan baik secara sosial, emosional, spritual dan juga moral (karakter). Pendidikan holistik ini dianggap mampu dalam menjawab tantangan yang ada di dunia pendidikan dimana masih ada lembaga yang hanya berfokus kepada akademik saja, dengan adanya penggabungan pendidikan holistik dengan pendekatan sufisme dipandang dapat menciptakan pembelajaran yang lebih efisien dan juga inovatif. Hal itu dapat diimplementasikan di lembaga pendidikan Islam dalam pengembangan kurikulum dimana pengembangan kurikulum sendiri juga penting untuk dilakukan secara terus menerus sesuai kebutuhan. Tujuan dari penelitian ini adalah mengetahui bahwa pendidikan holistik mampu diciptakan dengan pendekatan sufisme melalui pengembangan kurikulum. Metode yang dilakukan adalah metode library research. Penelitian kepustakaan adalah sebuah metode yang tidak mengharuskan peneliti terjun langsung ke lapangan, melainkan mencari datanya melalui karya-karya tulis ilmiah, seperti jurnal, buku, artikel. Hasil penelitian ini bahwa pendidikan holistik dengan pendekatan sufisme dalam pengembangan kurikulum mampu memberikan dampak yang baik bagi peserta didik itu sendiri teruta dalam spiritual, sosial, dan moral.
Konsep Filsafat Barat dan Islam Tentang Sumber Pengetahuan (Perspektif Rene Descartes, John Locke, dan Al-Ghazali)
Authors: Anshari Muhammad Isa 
Published: August 2024

Dalam sejarah terdapat perdebatan yang penting antara filsafat barat dan filsafat islam. Perdebatan ini berkaitan dengan sumber pengetahuan manusia dan apakah peran akal, panca indera atau hati yang lebih diutamakan dalam proses mendapatkan pengetahuan yang benar. Peneitian ini melibatkan pandangan Al-Ghazali, Rene Descartes, dan John Locke, Penelitian ini menggunakan metode studi literatur. Studi literatur merupakan metode penelitian yang menggunakan informasi dan data yang berada di perpustakaan. Dalam konteks perdebatan ini, pandangan barat tentang epistemologi yang diwakilkan oleh Rene Descartes memandang akal manusia sebagai sumber pengetahuan menyusun suatu metode yang dikenal dengan metode metode keraguan, di sisi lain John Locke menyoroti peran indra manusia sebagai sumber pengetahuan dan menyusun teori tabula rasa. Di tengah pandangan Barat ini, Al-Ghazali menghadirkan perspektif Islam dengan menekankan peran intuisi atau hati dalam mencapai pengetahuan tertinggi. Dalam tulisan ini, kita akan melihat pemikiran dan perbandingan perspektif tiga tokoh yaitu Al-Ghazali, Rene Descartes, dan John Locke. Masing-masing dari mereka memiliki pandangan yang berbeda terhadap sumber pengetahuan yang benar.