bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive impairment and the gut-brain axis during 2014–2023: a bibliometric analysis
Authors: He Jindi , Wu Jiaxun , Liu Juan , Wu Hangcai , Hua Heliu 
Published: July 2024

BackgroundThe burden on society grows as the number of individuals with cognitive impairment rises. Numerous research have discovered a connection between cognitive impairment and the gut-brain axis, which is useful in examining the pathophysiology of cognitive impairment and potential therapeutic approaches. As a result, this article explores developments and trends in the research concerning the gut-brain axis and cognitive impairment through a bibliometric analysis of the contributions made by various countries/regions, institutions, authors, and journals.MethodsWe looked for articles on gut-brain axis and cognitive impairment from 2014 to 2023 in the Web of Science Core Collection. For the descriptive analysis, figures and tables were taken using GraphPad Prism 6 and WPS Office 2024. For the visual analysis of the countries/regions, institutions, authors, and keywords, VOSviewer was utilized.ResultsWe obtained 458 publications from 1 January 2014 to 9 September 2023. The country with the most publications (175, 38.21%) was China. The country with the greatest total number of citations (3,138, 17.22%) was the United States of America. The highest number of articles (15, 3.26%) was issued by Zhejiang University. The most published first author is Karsas M. In this field, Nutrients have published the most articles (24). The most often occurring keywords include “Alzheimer’s disease,” “cognitive impairment,” “gut microbiota,” “inflammation,” “diet,” etc. “Stroke,” “tau,” “probiotics,” “exercise,” “fecal microbiota transplantation,” etc. emerged later.ConclusionAn increasing amount of research has focused on the connection between cognitive impairment and the gut-brain axis. In this area, the United States of America and China have both made significant contributions. The author team’s collaboration has to be improved. Our study contributes to understanding the field’s current state and predicting its future trend.
Difference between arterial and venous peak optical density after thrombectomy is associated with functional outcomes
Authors: Liu Guangzhi , Cao Jianghui , Zhou Peiyang , Sun Dong , Kang Zhiming , Fan Ruixue , Mei Bin , Zhang Junjian 
Published: July 2024

BackgroundThe density of contrast medium in digital subtraction angiography (DSA) have been used to evaluate the cerebral circulation function. Our aim was to study the effect of difference in arteriovenous peak optical density (POD) after thrombectomy on functional outcomes.MethodsConsecutive patients with acute ischemic stroke due to large vessel occlusion who underwent thrombectomy were reviewed. We processed DSA images with ImageJ software to measure the POD of internal carotid artery (ICA) and cortical veins. The average POD of cortical veins (PODVA) and the POD difference between ICA and cortical veins (PODICA-CV) were calculated. Primary outcome was good functional outcome (modified Rankin scale score of 0–2 at 90 days).ResultsOne hundred sixty-six patients were finally included in the study. Patients with good functional outcome had lower ipsilateral PODVA (median [interquartile range (IQR)], 257.198 [216.623–296.631] vs. 290.944 [248.647–338.819], p &lt; 0.001) and lower ipsilateral PODICA-CV (median [IQR], 128.463 [110.233–153.624] vs. 182.01 [146.621–211.331], p &lt; 0.001). Multivariable logistic regression analyses showed that ipsilateral PODVA (odds ratio [OR] 0.991, 95% confidence interval [CI] 0.984–0.999, p = 0.019) and ipsilateral PODICA-CV (OR 0.975, 95% CI 0.963–0.986, p &lt; 0.001) were associated with good functional outcome. The predictive ability was significantly enhanced in the model including ipsilateral PODICA-CV (0.893 vs. 0.842, p = 0.027). No correlation was found between ipsilateral PODICA-CV and expanded Thrombolysis in Cerebral Infarction grades (r = −0.133, p = 0.099).ConclusionIpsilateral PODICA-CV is an additional indicator of cerebral reperfusion status and predicts functional outcomes after thrombectomy.
Thiamine use is associated with better outcomes for traumatic brain injury patients
Authors: Wang Ruoran , Zeng Yunhui , Xu Jianguo , He Min 
Published: July 2024

BackgroundTraumatic brain injury (TBI) is a global health concern that often leads to poor prognosis. We designed this study to explore whether thiamine use is associated with a better prognosis of TBI.MethodsTBI patients selected from the Medical Information Mart for Intensive Care-III database were included in the study. Univariate and multivariate Cox regression analyses were performed to examine the relationship between thiamine use and mortality in TBI patients. Propensity score matching (PSM) was utilized to generate balanced cohorts of the non-thiamine use group and the thiamine use group. Subgroup analysis was performed in the cohort after PSM to verify the association between thiamine use and mortality in TBI patients across different stratifications.ResultsThe incidence of thiamine use in TBI was 18.3%. The thiamine use group had a lower 30-day mortality rate (p &lt; 0.001), a longer length of ICU stay (p &lt; 0.001), and a longer length of hospital stay (p &lt; 0.001) than the non-thiamine use group, both in the primary cohort before PSM and the cohort after PSM. A multivariate Cox regression analysis confirmed that thiamine use was independently associated with mortality (OR = 0.454, p &lt; 0.001) after adjusting for confounding effects. In the cohort after PSM, the subgroup analysis showed that thiamine use is associated with lower mortality in TBI patients with a Glasgow Coma Scale (GCS) score of &lt; 13, but it is not associated with mortality in TBI patients whose GCS score is ≥13.ConclusionThiamine supplementation is effective in improving the outcome of TBI, except in cases of mild TBI. The optimal thiamine supplementation strategy for TBI is worthwhile to be explored in future studies.
A novel nutritional inflammation index for predicting mortality in acute ischemic stroke patients: insights into advanced lung cancer inflammation index from the Medical Information Mart for Intensive Care-IV database
Authors: Huang Yongwei , Wang Xiaoyi , Li Zongping , Yin Xiaoshuang 
Published: July 2024

ObjectiveThis investigation aimed to delineate the association between the advanced lung cancer inflammation index (ALI) and all-cause mortality (ACM) in individuals experiencing acute ischemic stroke (AIS).MethodsDrawing on information from the Medical Information Mart for Intensive Care (MIMIC)-IV database, release 2.2, covering the years 2012 to 2019, this research assessed the advanced lung cancer inflammation index (ALI) by factoring in body mass index (BMI), serum albumin levels (ALB), and the neutrophil-to-lymphocyte ratio (NLR). Patients with AIS were identified using codes from the International Classification of Diseases (ICD). To address potential confounding factors, a 1:1 propensity score matching (PSM) method was utilized. The investigation identified the pivotal ALI level impacting patient survival using maximally selected rank statistics. It then examined the effects on short- and long-term ACM through multivariate Cox proportional hazards regression models and Kaplan–Meier (K–M) survival analysis. Additionally, restricted cubic spline (RCS) methods were applied to delve into the linear or nonlinear nature of the relationship between ALI and ACM, with further insights gained from interaction and subgroup analyses.ResultsThe cohort comprised 838 AIS patients. Post-PSM, analysis involved 199 matched patient pairs. Adjusted Cox proportional hazard models indicated a significant association of low ALI (&lt;10.38) with increased in-hospital ACM, both before (HR: 1.98; 95% CI: 1.36–2.88; p &lt; 0.001) and after PSM (HR: 2.16; 95% CI: 1.32–3.52; p = 0.002). Associations of low ALI with elevated risk were consistent across ICU, 30 days, 90 days, and 1 year ACM pre- and post-PSM. Subsequent RCS analysis post-PSM underscored a negative nonlinear relationship between ALI and ACM over both short and long terms, without significant interaction effects across different subgroups for ACM.ConclusionIn this retrospective cohort study, by utilizing a nationally representative sample of United States patients with AIS, our analysis elucidates a negative correlation between the ALI and ACM in individuals with AIS, underscoring the utility of ALI as a novel, efficacious, and accessible inflammatory biomarker for prognosticating ACM. These results carry profound implications for public health policy and practice. A deeper comprehension of these associations can empower public health practitioners and researchers to devise more targeted interventions and policies, aimed specifically at catering to the distinct needs of the AIS patient population, thereby enhancing their health outcomes. The further research in other races/ethnicity is urgent, particularly before applying these findings in clinical practice.
Virtual clinical trial-based study for clinical evaluation of projection-reduced low-dose cone-beam CT for image guided radiotherapy
Authors: Wang Meijiao , Yao Kaining , Zhao Yixin , Geng Jianhao , Zhu Xianggao , Liu Zhiyan , Li Yongheng , Wu Hao , Du Yi 
Published: July 2024

PurposeRepeated cone-beam CT (CBCT) scans for image-guided radiotherapy (IGRT) increase the health risk of radiation-induced malignancies. Patient-enrolled studies to optimize scan protocols are inadequate. We proposed a virtual clinical trial-based approach to evaluate projection-reduced low-dose CBCT for IGRT.Materials and methodsA total of 71 patients were virtually enrolled with 26 head, 23 thorax and 22 pelvis scans. Projection numbers of full-dose CBCT scans were reduced to 1/2, 1/4, and 1/8 of the original to simulate low-dose scans. Contrast-to-noise ratio (CNR) values in fat and muscle were measured in the full-dose and low-dose images. CBCT images were registered to planning CT to derive 6-degree-of-freedom couch shifts. Registration errors were statistically analyzed with the Wilcoxon paired signed-rank test.ResultsAs projection numbers were reduced, CNR values descended and the magnitude of registration errors increased. The mean CNR values of full-dose and half-dose CBCT were &gt;3.0. For full-dose and low-dose CBCT (i.e. 1/2, 1/4 and 1/8 full-dose), the mean registration errors were&lt; ± 0.4 mm in translational directions (LAT, LNG, VRT) and ±0.2 degree in rotational directions (Pitch, Roll, Yaw); the mean magnitude of registration errors were&lt; 1 mm in translation and&lt; 0.5 degree in rotation. The couch shift differences between full-dose and low-dose CBCT were not statistically significant (p&gt;0.05) in all the directions.ConclusionThe results indicate that while the impact of dose-reduction on CBCT couch shifts is not significant, the impact on CNR values is significant. Further validation on optimizing CBCT imaging dose is required.
Preventing new substance use behaviors in youth: evaluation of a two-year comprehensive program
Authors: Zerhouni Oulmann , Loisy Sandra , Bouthier Renaud , Flaudias Valentin 
Published: July 2024

IntroductionThe Avenir Santé Association implemented a comprehensive prevention program targeting the consumption of the emerging psychoactive substances ecstasy (MDMA), cannabidiol (CBD), and nitrous oxide (N2O).MethodsThe program was evaluated through four actions: (i) training for association workers (n = 84) (ii) on-site student party interventions (n = 248), (iii) social network-based prevention (n = 186), and (iv) provision of prevention tools for party organizers (n = 148).ResultsResults showed a significant increase in understanding of emerging substances among association workers, with a pre-training score of M = 15.76 (SD = 3.65) and a post-training score of M = 18.29 (SD = 2.50). Increased awareness and reflective attitudes toward substance use were observed among young people participating in field actions, with pre- and post-intervention scores for MDMA use intentions being M = 15.89 (SD = 4.60) and M = 19.17 (SD = 3.33), respectively. Similarly, awareness of CBD effects increased from M = 14.18 (SD = 4.14) to M = 17.60 (SD = 3.31). Exposure to Instagram posts on N2O led to more negative attitudes toward N2O among young people, with a significant change in scores from M = 8.16 (SD = 1.57) to M = 8.42 (SD = 1.26). However, exposure to a website providing information about emerging substances did not produce any significant effect.DiscussionIn conclusion, this initiative underscores the usefulness of facilitator training, field interventions, and certain online information strategies for substance judgment and usage intentions. Future prevention programs can advantageously incorporate these actions.
Uptake of COVID-19 vaccination among community-dwelling individuals receiving healthcare for substance use disorder and major mental illness: a matched retrospective cohort study
Authors: Richard Lucie , Holland Anna , Aghanya Vivian , Campitelli Michael A. , Hwang Stephen W. 
Published: July 2024

IntroductionPatients with major mental illness (MMI) and substance use disorders (SUD) face barriers in accessing healthcare. In this population-based retrospective cohort study, we investigated the uptake of COVID-19 vaccination in Ontario, Canada among community-dwelling individuals receiving healthcare for major mental illness (MMI) and/or substance use disorders (SUD), comparing them to matched general population controls.MethodsUsing linked health administrative data, we identified 337,290 individuals receiving healthcare for MMI and/or SUD as of 14 December 2020, matched by age, sex, and residential geography to controls without such healthcare. Follow-up extended until 31 December 2022 to document vaccination events.ResultsOverall, individuals receiving healthcare for MMI and/or SUD (N = 337,290) had a slightly lower uptake of first (cumulative incidence 82.45% vs. 86.44%; hazard ratio [HR] 0.83 [95% CI 0.82–0.83]) and second dose (78.82% vs. 84.93%; HR 0.77 [95% CI 0.77–0.78]) compared to matched controls. Individuals receiving healthcare for MMI only (n = 146,399) had a similar uptake of first (87.96% vs. 87.59%; HR 0.97 [95% CI 0.96–0.98]) and second dose (86.09% vs. 86.05%, HR 0.94 [95% CI 0.93–0.95]). By contrast, individuals receiving healthcare for SUD only (n = 156,785) or MMI and SUD (n = 34,106) had significantly lower uptake of the first (SUD 78.14% vs. 85.74%; HR 0.73 [95% CI 0.72–0.73]; MMI &amp; SUD 78.43% vs. 84.74%; HR 0.76 [95% CI 0.75–0.77]) and second doses (SUD 73.12% vs. 84.17%; HR 0.66 [95% CI 0.65–0.66]; MMI &amp; SUD 73.48% vs. 82.93%; HR 0.68 [95% CI 0.67–0.69]).DiscussionThese findings suggest that effective strategies to increase vaccination uptake for future COVID-19 and other emerging infectious diseases among community-dwelling people with SUD are needed.
Implementing evidence-based practices in rural settings: a scoping review of theories, models, and frameworks
Authors: Brady Robert E. , Lyons Kathleen D. , Stevens Courtney J. , Godzik Cassandra M. , Smith Andrew J. , Bagley Pamela J. , Vitale Elaina J. , Bernstein Steven L. 
Published: July 2024

BackgroundRural healthcare has unique characteristics that affect the dissemination and implementation of evidence-based interventions. Numerous theories, models, and frameworks have been developed to guide implementation of healthcare interventions, though not specific to rural healthcare. The present scoping review sought to identify the theories, models, and frameworks most frequently applied to rural health and propose an approach to rural health research that harnesses selected constructs from these theories, models, and frameworks. This resulting synthesis can serve as a guide to researchers, policy makers, and clinicians seeking to employ commonly used theories, models, and frameworks to rural health.MethodsWe used the Scopus abstract indexing service to identify peer-reviewed literature citing one or more of theories, models, or frameworks used in dissemination and implementation research and including the word “rural” in the Title, Abstract, or Keywords. We screened the remaining titles and abstracts to ensure articles met additional inclusion criteria. We conducted a full review of the resulting 172 articles to ensure they identified one or more discrete theory, model, or framework applied to research or quality improvement projects. We extracted the theories, models, and frameworks and categorized these as process models, determinant frameworks, classic theories, or evaluation frameworks.ResultsWe retained 61 articles of which 28 used RE-AIM, 11 used Community-Based Participatory Research (CBPR) framework, eight used the Consolidated Framework for Implementation Research (CFIR), and six used the integrated-Promoting Action on Research Implementation in Health Services (iPARIHS). Additional theories, models, and frameworks were cited in three or fewer reports in the literature. The 14 theories, models, and frameworks cited in the literature were categorized as seven process models, four determinant frameworks, one evaluation framework, and one classic theory.ConclusionsThe RE-AIM framework was the most frequently cited framework in the rural health literature, followed by CBPR, CFIR, and iPARIHS. A notable advantage of RE-AIM in rural healthcare settings is the focus on reach as a specified outcome, given the challenges of engaging a geographically diffuse and often isolated population. We present a rationale for combining the strengths of these theories, models, and frameworks to guide a research agenda specific to rural healthcare research.Systematic Review Registrationhttps://osf.io/fn2cd/.
Revitalizing CPAP adherence: lessons from THN study in patients with hypoglossal nerve stimulators
Authors: Mwenge Gimbada Benny , Bousata Jamila , Rodenstein Daniel 
Published: July 2024

ObjectiveThis retrospective study aimed to address acceptance and long-term adherence to Continuous Positive Airway Pressure (CPAP) treatment among non-responder patients to ImThera THN system who initially declined this therapy.Material and methodsWe employed a structured outpatient approach to communicate THN study results, categorize initial CPAP nonadherence reasons, and encourage CPAP trials through tailored appointments. Recorded follow-ups addressed individual concerns, providing medical guidance and acknowledging person-specific challenges. Adherence data were collected using CPAP hour meters at predetermined intervals, following Belgium's social security stipulations.ResultsBetween July 2014 and October 2016, eleven participants, including one woman, with prior CPAP experience (average 2 months) were enrolled. Initial non-adherence was linked to ENT or psychological factors. Ten patients agreed to CPAP trials, where interventions included changing CPAP brand, pressure adjustments, mask changes, and additional measures like cognitive-behavioral therapy and nasal spray. After 1 year, mean adherence was 6.3 ± 2 h/day, and average CPAP usage duration was 8.67 ± 2.13 years. As of November 2023, eight out of eleven patients were still actively using CPAPConclusionIn this investigation, we challenged the concept of CPAP non-adherence, highlighting evolving adherence and the significance of continuous monitoring and personalized interventions. Our findings underscore ongoing patient education, multidisciplinary support, and dynamic intervention adaptation for enhanced adherence in challenging patient populations. The results provide insights applicable to non-adherent patients with obstructive sleep apnea, emphasizing the importance of individualized care and sustained engagement for improved CPAP acceptance.
Solar-Powered Combined Cooling, Heating, and Power Energy System with Phase-Change Material and Water Electrolysis: Thermo-Economic Assessment and Optimization
Authors: Aieneh Koorosh , Mehranfar Sadegh , Yazdi Sotoude Mohammad , Sadeghi Shayan , Mahmoudzadeh Andwari Amin 
Published: July 2024

A solar-powered combined cooling, heating, and power (CCHP) plant integrated with a water electrolysis unit is investigated in terms of energy, exergy, and exergo-economic (3E) assessments. A comprehensive parametric study and optimization is conducted following the thermodynamic and exergo-economic assessment of the proposed system to evaluate the key performance parameters of the system for efficiency and economic factors. This system employs a heliostat field and a receiver tower by taking advantage of thermal energy from the sun and produces a continuous energy supply with an integrated phase-change material (PCM) tank to store the heat. In addition, a supercritical CO2 Rankine cycle (RC), an ejector refrigeration cooling (ERC) system, and a PEM water electrolyzer are coupled to produce cooling, heating, power, and hydrogen. Thermodynamic analysis indicates that the system exergy efficiency and energy efficiency are improved to 33.50% and 40.61%, respectively, while the total cost rate is 2875.74 USD/h and the total product cost per exergy unit is 25.65 USD/GJ. Additionally, the system produces a net generated power, heating load, and cooling load of 11.70, 13.92, and 2.60 MW, respectively, and a hydrogen production rate of 12.95 g/s. A two-objective optimization approach utilizing a non-dominated sorting genetic algorithm (NSGA) was performed, demonstrating that the system’s ideal design point offers a cost rate of 1263.35 USD/h and an exergetic efficiency of 34.17%.
FACTORS AFFECTING WORK MOTIVATION: THE MODERATION ROLE OF THE WORK ENVIRONMENT
Authors: Alkatiri Fauzi Ahmad , Indrawati Ratna , Nofierni Nofierni 
Published: July 2024

Human Resource Development (HRD) menyimpulkan bahwa penurunan motivasi kerja perawat karena ketidakpuasan terhadap kompensasi dan dukungan organisasi berupa pengembangan karier yang diberikan, sehingga banyak pekerjaan yang tidak dapat diselesaikan perawat. Hal tersebut menyebabkan terjadinya penurunan tingkat kepuasan pasien di tahun 2021 menjadi 68%. Tujuan penelitian ini adalah untuk mengungkap secara empiris pengaruh kompensasi dan pengembangan karier terhadap motivasi kerja dengan lingkungan kerja sebagai variabel moderasi. Jenis penelitian termasuk dalam kuantitatif dengan desain cross-sectional study. Penelitian ini terdiri atas 2 variabel bebas yaitu kompensasi (X1) dan pengembangan karier (X2) yang akan diukur pengaruhnya terhadap variabel terikat yaitu motivasi kerja (Y) dan terdapat variabel moderasi yaitu lingkungan kerja (X3) yang menginteraksi hubungan antara variabel bebas dengan variabel terikat. Instrumen menggunakan kuesioner. Skala yang digunakan yaitu likert poin 4-1. Populasi yang digunakan adalah perawat yang telah bekerja selama 3 tahun. Teknik sampel menggunakan non probability dengan metode purposive sampling, dengan perhitungan menggunakan rumus slovin, sehingga didapatkan 107 responden. Teknik pengumpulan data menggunakan metode survei, dan teknik analisa data menggunakan PLS-SEM dengan program smart-PLS serta analisa three-box method. Hasil analisa menyimpulkan bahwa kompensasi, pengembangan karier dan lingkungan kerja berkontribusi kuat dalam memengaruhi motivasi kerja. Kompensasi dan lingkungan kerja berpengaruh positif dan signifikan terhadap motivasi kerja, sedangkan pengembangan karier tidak memengaruhi motivasi kerja. Uji moderasi menyimpulkan lingkungan kerja tidak mampu memperkuat pengaruh kompensasi dan pengembangan karier terhadap motivasi kerja.