bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Urate and Incidence of Kidney Disease Among Veterans with Gout
Authors: Krishnan Eswar , Akhras Kasem S. , Sharma Hari , Marynchenko Maryna , Wu Eric , Tawk Rima H. , Liu Jinan , Shi Lizheng 
Published: May 2013

Objective.To study the association between serum urate level (sUA) and the risk of incident kidney disease among US veterans with gouty arthritis.Methods.From 2002 through 2011 adult male patients with gout who were free of kidney disease were identified in the data from the Veterans Administration VISN 16 database and were followed until incidence of kidney disease, death, or the last available observation. Accumulated hazard curves for time to kidney disease were estimated for patients with average sUA levels > 7 mg/dl (high) versus ≤ 7 mg/dl (low) based on Kaplan-Meier analyses; and statistical comparison was conducted using a log-rank test. A Cox proportional hazard model with time-varying covariates was used to estimate the unadjusted and adjusted hazard ratios for kidney disease.Results.Eligible patients (n = 2116) were mostly white (53%), with average age 62.6 years, mean body mass index 31.2 kg/m2, and high baseline prevalence of hypertension (93%), hyperlipidemia (67%), and diabetes (20%). Mean followup time was 6.5 years. The estimated rates of all incident kidney disease in the overall low versus high sUA groups were 2% versus 4% at Year 1, 3% versus 6% at Year 2, and 5% versus 9% at Year 3, respectively (p < 0.0001). After adjustment, high sUA continued to predict a significantly higher risk of kidney disease development (HR 1.43, 95% CI 1.20–1.70).Conclusion.Male veterans with gout and sUA levels > 7 mg/dl had an increased incidence of kidney disease.
Genèse et enjeux épistémologiques de la psychologie clinique périnatale
Authors: Missonnier Sylvain 
Published: May 2013

L’exploration de la genèse récente et des enjeux épistémologiques de la psychologie clinique périnatale impose un rappel de la source matricielle de la psychologie clinique qui se définit par son objet à double face : l’exploration du quotidien de la réalité psychique consciente/inconsciente, subjective/intersubjective du sujet en situation sous ses formes individuelle/groupale, « normales »/« pathologiques » ; la mise en œuvre pratique de dispositifs de rencontres intersubjectives propices à l’observation contenante de la processualité associative verbale/non verbale, focale/libre et à la mise en sens subjectivante de sa phénoménologie et de ses obstacles conflictuels inhibiteurs et dissociatifs. La méthodologie clinique de cette réalité psychique est inséparable de sa mise en œuvre croisée chez tous les acteurs en présence. Aussi, la première face de l’objet de la psychologie clinique périnatale sera l’exploration du quotidien de la réalité psychique consciente/inconsciente, subjective/intersubjective du sujet en situation de (re)devenir parent, naître humain et être soignant sous ses formes « normales »/« pathologiques », individuelle, conjugale et groupale. L’attention envers les possibilités des parents et des soignants à bénéficier de cadres intimes, privés et institutionnels propices à la métabolisation de cette amplification de la processualité associative verbale et non verbale (en particulier somatique) inhérente aux transformations biopsychiques de la parentalisation et à son accompagnement professionnel, constitue la deuxième face de l’objet de la psychologie clinique périnatale. La promesse heuristique de la psychologie clinique périnatale est discutée.
L'audacieuse clinique du couple
Authors: Bastien Danielle , Janssen Christophe 
Published: May 2013

Les deux auteurs, une psychanalyste et un psychothérapeute, ayant une pratique commune en clinique de couple, présentent leurs cadres de travail et la visée de cette clinique particulière. Et ils rappellent qu’il n’était pas aisé historiquement de soutenir une clinique du couple dans une perspective psychanalytique ! Cela étant, les auteurs proposent une filiation épistémologique à divers auteurs (Freud, Lacan, Winnicott, Roussillon) soulignant la difficulté pour la psychanalyse d’intégrer la notion de couple, et pourtant la pertinence de le faire si l’on définit analytiquement le concept de lien. Par ailleurs, il s’agit pour chacun d’eux de préciser la façon dont ils pensent ce lien. « Complaisance mutuelle inconsciente » si on le situe au niveau des fantasmes mis en tension, « illusion conjugale » si on l’énonce en termes de transitionalité. Enfin et pour conclure, ils définissent la visée de ce travail clinique, encore souvent méconnu dans le monde analytique.
Evaluation of the Ability of a Photocoagulator to Rupture the Retinal Vein and Bruch’s Membrane for Potential Vein Bypass in Retinal Vein Occlusion
Authors: McAllister Ian L. , Vijayasekaran Sarojini , Xia Wei , Yu Dao-Yi 
Published: May 2013

BACKGROUND AND OBJECTIVE:
To evaluate the laser power required to rupture both the retinal vein and Bruch’s membrane in a porcine model using a new laser system for treatment of retinal vein occlusion.

MATERIALS AND METHODS:
The retina was treated in areas with and without an overlying vein. Sections through the laser sites were stained for light and transmission electron microscopy. The percentage of the laser sites with rupture of the retinal vein and Bruch’s membrane, the degree of tissue damage, and the diameter of the rupture in Bruch’s membrane were determined.

RESULTS:
The rate of vein rupture was 75% at 3 W, and rupture of Bruch’s membrane was achieved at all powers tested. The mean diameter of the rupture in Bruch’s membrane increased with laser power.

CONCLUSION:
The Integre Duo laser system (Ellex Medical Lasers, Adelaide, Australia) is capable of rupturing the retinal vein and Bruch’s membrane at lower powers than prior laser systems.

[
Ophthalmic Surg Lasers Imaging Retina.
2013;44:268–273.]
Injury Rehabilitation Overadherence: Preliminary Scale Validation and Relationships With Athletic Identity and Self-Presentation Concerns
Authors: Podlog Leslie , Gao Zan , Kenow Laura , Kleinert Jens , Granquist Megan , Newton Maria , Hannon James 
Published: May 2013

Context:
Evidence suggests that nonadherence to rehabilitation protocols may be associated with worse clinical and functional rehabilitation outcomes. Recently, it has been recognized that nonadherence may not only reflect a lack of rehabilitation engagement but that some athletes may “overadhere” to their injury-rehabilitation regimen or risk a premature return to sport. Presently, no measure of overadherence exists, and correlates of overadherence and risking a premature return to sport remain uncertain.

Objective:
To provide initial validation of a novel injury-rehabilitation overadherence measure (study 1) and to examine correlates of overadherence and risking a premature return to sport (study 2).

Design:
Cross-sectional study.

Setting:
High school athletes (study 1) and collegiate athletes (study 2).

Patients or Other Participants:
In study 1, 118 currently injured US adolescent athletes competing in a range of high school sports participated. In study 2, 105 currently injured collegiate athletes (National Collegiate Athletic Association Divisions I–III) volunteered.

Main Outcome Measure(s):
The Rehabilitation Overadherence Questionnaire was a novel instrument developed to assess injured athletes' tendency toward overadherence behaviors and beliefs. We used an adapted version of the Injury Psychological Readiness to Return to Sport Scale to assess the tendency to risk a premature return to sport.

Results:
In study 1, the construct validity of the overadherence measure was supported using principal axis factoring. Moreover, bivariate correlation and regression analyses indicated that self-presentation concerns and athletic identity were positive predictors of adolescent rehabilitation overadherence and a premature return to sport. Study 2 provided support for the 2-factor structure of the overadherence measure found in study 1 via confirmatory factor analysis. Further support for the relationship among self-presentation concerns, athletic identity, and rehabilitation overadherence was also noted.

Conclusions:
The Rehabilitation Overadherence Questionnaire is a valid and reliable measure of overadherence.
Factor V Leiden Thrombophilia in a Female Collegiate Soccer Athlete: A Case Report
Authors: Erickson Kendra , Powers Michael E. 
Published: May 2013

Objective:
To raise awareness among health care providers caring for an active population to an uncommon genetic mutation that increases the risk for a potentially fatal venous thromboembolism.

Background:
A 19-year-old previously healthy female collegiate soccer athlete complained of coughing and progressively decreased exercise tolerance, which were attributed to a recent illness and lack of sleep. Later that evening, she complained of dyspnea and pleuritic pain and was referred to the emergency department. Bilateral pulmonary emboli were identified with computed tomography, and a hypercoagulable panel revealed that the patient was heterozygous for the factor V Leiden mutation.

Differential Diagnosis:
Pneumonia, pneumothorax, pericarditis, pleuritis, gastroesophageal reflux disease, pulmonary embolism.

Treatment:
Intravenous heparin therapy was initiated immediately in the emergency department. This was followed by inpatient anticoagulant therapy for 5 days and outpatient anticoagulant therapy for an additional 12 months. During this time, the patient was unable to participate in soccer drills or return to competition and was limited to conditioning activities due to the risk of increased bleeding time.

Uniqueness:
Documented cases of pulmonary embolism in a young athletic population are rare and are usually associated with genetic risk factors. Factor V Leiden is a relatively uncommon genetic mutation that dramatically increases the risk for venous thromboembolism. Although the fatality rate in this population is low, fatality is preventable if the condition is recognized early and managed properly.

Conclusions:
Athletes should be encouraged to communicate with their athletic trainers regarding any changes in health status or medication usage. When an athlete presents with nonspecific symptoms such as dyspnea and chest pain, athletic trainers should consider the possibility of pulmonary embolism. A high degree of suspicion results in early diagnosis and treatment and may prevent a fatal event.
Primary Extramedullary Plasmacytoma of Maxillary Sinus
Authors: Ray Chinmaya Sundar , Mishra Aparajita , Khatua Rabindra Kumar , Baliarsingh Prasenjit 
Published: May 2013

ABSTRACT
A rare case of extramedullary plasmacytoma of maxillary sinus in a 58-year-old man presenting with right-sided nasal obstruction and intermittent blood tinged nasal crusting. Nasal endoscopy revealed that a dark red colored mass arising from the lateral wall of nose. A biopsy specimen was diagnosed as plasmacytoma (Kappa light chain type). Serum and urine electrophoresis failed to detect any myeloma component or Bence-Jones protein. All other screening tests to rule out multiple myeloma were negative. These findings confirmed the diagnosis of extramedullary plasmacytoma. The mass was completely excised by lateral rhinotomy approach. No recurrence has been noted at the end of 6 months follow-up.

How to cite this article
Ray CS, Mishra A, Khatua RK, Baliarsingh P. Primary Extramedullary Plasmacytoma of Maxillary Sinus. Clin Rhinol An Int J 2013;6(1):51-53.
Endoscopic Management of Nasal Myiasis: A 10 Years Experience
Authors: Agrawal Arpit , Goyal Anuj , Yadav SPS , Ranga Rupender K 
Published: May 2013

ABSTRACT

Background
The present study was undertaken to compare the efficacy of endoscopic removal with conventional techniques in nasal myiasis patients.

Materials and methods
Out of 144, 72 nasal myiasis patients treated using Hopkins rigid nasal endoscope and visible caudal end of maggots was grasped with Blakesley forceps and removed during endoscopy. Rests were identified from crawling movements or the visible caudal end was buried in necrotic material. Complete clearance of cavernous cavity of maggots in affected nasal cavity from anterior nares to choanae was done and same was repeated on other side if needed.

Results
The mean age in two groups was 57.5 years (range 40-60) in nasal myiasis patients whereas there were 20% males and 80% females. Mean duration of nasal symptom in both groups was 2 days. Endoscopically mean 120 maggots (range: 90-160) were removed in first sitting as compared to conventional technique where mean of 80 (range: 40-90) were achieved. The mean duration of endoscopic treatment was 2 days whereas in control group it was 5 days. The difference was statistically significant (p < 0.001).

Conclusion
Nasal endoscopic procedure is superior to the manual extraction method for removal of maggots. The larvae located in deep and inaccessible areas can be identified and removed easily. The disease was controlled in shorter time and in fewer sittings. Further the quick and complete eradication of myiasis ensures less damage to the intranasal tissues.

How to cite this article
Ranga RK, Yadav SPS, Goyal A, Agrawal A. Endoscopic Management of Nasal Myiasis: A 10 years Experience. Clin Rhinol An Int J 2013;6(1):58-60.
The Marian Aesthetics of Edgar Allan Poe
Authors: Meyer Joseph Matthew 
Published: May 2013

Abstract
This study explores Poe's aesthetic vision of the Virgin Mary in “Morella” and the “Catholic Hymn”—or the “Hymn,” as the poem is referred to today. The argument put forth is that Poe's depictions of Mary in the texts previously mentioned are influenced by his early Anglican upbringing. More specifically, the author traces Poe's early exposure to both the Protestant Episcopal Church in Virginia and the Anglican Church of England, concluding that the latter appears to have had a more pronounced influence on Poe's Marian aesthetics. The anti–Roman Catholic themes we find in “Morella” indicate that Poe was well aware of the common charges of the time that were levied against Roman Catholics, especially the argument concerning Mary as a type of divine intercessor. However, the beautifully poetic language attributed to Mary that we find in the “Catholic Hymn” conveys Poe as a man who revered and adored the Virgin. Poe's Anglican upbringing—especially his exposure to the Church of England—would have taught him that the proper amount of veneration for Mary lies somewhere in between the Roman Catholic Church and the more evangelical Protestant sects of Christianity, and it is in this middle space, the author of the study claims, that we are able to see Poe's Marian aesthetics.
Morbid Conditions Poe and the Sublimity of Disease
Authors: McGhee J. Alexandra 
Published: May 2013

Abstract
At first glance, Edgar Allan Poe's worldview as presented in his writings seems to deal more with experiences of uncanny horror than sublimity. However, Poe's perversity cannot simply be understood as calling attention to the horror of existence. Through an analysis of “The Fall of the House of Usher” (1839) and “Berenice” (1835), this essay claims that accessing the sublime experience in Poe depends on a combination of perverseness, disease, and the uncanny. Because Roderick Usher and Egaeus are able, through their monomania, to dissolve meaning in the objects around them, their contemplation of these newly unheimlich objects gives them access to the inexpressibility and ineffability of the sublime state.
I employ Poe's essay “The Imp of the Perverse,” which focuses on “perverseness as a radical, primitive, irreducible faculty or sentiment of the soul, the propensity to do wrong for the wrong's sake,” in my treatment of these stories. Although an obsession with the abyss is what drives these characters over its edge, my analysis reveals that only perverseness makes the sublime experience possible. The result is not the upward transcendence of eighteenth-century philosophers like Edmund Burke and Immanuel Kant, but rather a journey downward to a total loss of control and a destruction of the self rather than an affirmation of the individual intellect over natural forces. However, this collapse accords with the cosmology Poe sets forth in Eureka, which posits that all things diffuse and radiate throughout the universe from a common source, eventually dissolving back into oneness.
Teologia moral, bioética e cultura da morte: desafios para a Pastoral
Authors: Trasferetti José Antonio 
Published: May 2013

Este artigo objetiva explicitar a Teologia Moral em suas relações práticas com o cotidiano da sociedade civil em contexto de crise social. Num universo multicêntrico, sem um princípio moral estruturante, os desafios são imensos, sobretudo diante do vasto campo da bioética e da “cultura da morte” presente na sociedade latino-americana. Neste artigo, vamos considerar a Teologia Moral e sua produção num contexto de crise social. Na verdade, trata-se de apresentar caminhos, orientações práticas para a realização de escolhas morais que permitam aprimorar o sentido da vida em ambientes de pluralismos abertos sem um horizonte de estrutura definido. A teologia moral enquanto ciência prática deve produzir uma reflexão que contribua para a formulação de uma consciência que permita o pleno discernimento tendo em vista escolhas morais consistentes e precisas.#] Este artigo objetiva explicitar a Teologia Moral em suas relações práticas com o cotidiano da sociedade civil em contexto de crise social. Num universo multicêntrico, sem um princípio moral estruturante, os desafios são imensos, sobretudo diante do vasto campo da bioética e da “cultura da morte” presente na sociedade latino-americana. Neste artigo, vamos considerar a Teologia Moral e sua produção num contexto de crise social. Na verdade, 1 Coordenador do Programa de Pós-Graduação Strictu sensu em Filosofia da PUC-Campinas (2004-2007). Diretor da Faculdade de Filosofia da mesma universidade (2006-2010). Editor da revista Prhónesis (2004-2007). Presidente da Sociedade Brasileira de Teologia moral (2003-2009).trata-se de apresentar caminhos, orientações práticas para a realização de escolhas morais que permitam aprimorar o sentido da vida em ambientes de pluralismos abertos sem um horizonte de estrutura definido. A teologia moral enquanto ciência prática deve produzir uma reflexão que contribua para a formulação de uma consciência que permita o pleno discernimento tendo em vista escolhas morais consistentes e precisas.#]
Measurable Residual Disease and Clinical Outcomes in Chronic Lymphocytic Leukemia
Authors: Rios-Olais Fausto Alfredo , McGary Alyssa K. , Tsang Mazie , Almader-Douglas Diana , Leis Jose F. , Buras Matthew R. , Hilal Talal 
Published: July 2024

ImportanceMeasurable residual disease (MRD) refers to the presence of disease at low levels not detected by conventional pathologic analysis. The association of MRD status as a surrogate end point of clinical outcome in chronic lymphocytic leukemia (CLL) has not been established in the era of targeted agents. Assessing the association of MRD with progression-free survival (PFS) may improve its role as a surrogate marker and allow its use to accelerate drug development.ObjectiveTo assess the association between MRD and PFS in CLL using data from prospective clinical trials that studied targeted agents or obinutuzumab-based treatment.Data SourcesClinical studies on CLL were identified via searches of PubMed, Embase, Scopus, and Web of Science from inception through July 31, 2023.Study SelectionProspective, single-arm, and randomized clinical trials that assessed targeted agents or obinutuzumab-based treatment and reported PFS by MRD status were included. Studies with insufficient description of MRD information were excluded.Data Extraction and SynthesisStudy sample size, median patient age, median follow-up time, line of treatment, MRD detection method and time points, and survival outcomes were extracted.Main Outcomes and MeasuresAnalyses of survival probabilities and hazard ratios (HRs) were conducted for PFS according to MRD status. Meta-analyses were performed using a random-effects model.ResultsA total of 11 prospective clinical trials (9 randomized and 2 nonrandomized) including 2765 patients were analyzed. Achieving undetectable MRD (uMRD) at 0.01% was associated with an HR of 0.28 (95% CI, 0.20-0.39; P &amp;lt; .001) for PFS. Median PFS was not reached in both groups (uMRD vs MRD), but the estimated 24-month PFS was better in the uMRD group (91.9% [95% CI, 88.8%-95.2%] vs 75.3% [95% CI, 64.7%-87.6%]; P &amp;lt; .001). The association of uMRD with PFS was observed in subgroup analyses in the first-line treatment setting (HR, 0.24; 95% CI, 0.18-0.33), relapsed or refractory disease setting (HR, 0.34; 95% CI, 0.16-0.71), and trials using time-limited therapy (HR, 0.28; 95% CI, 0.19-0.40).Conclusions and RelevanceThe findings of this systematic review and meta-analysis suggest that assessing MRD status as an end point in clinical trials and as a surrogate of PFS may improve trial efficiency and potentially allow for accelerated drug registration.
Long-Term Outcomes of Self-Fit vs Audiologist-Fit Hearing Aids
Authors: De Sousa Karina C. , Manchaiah Vinaya , Moore David R. , Graham Marien A. , Swanepoel De Wet 
Published: July 2024

ImportanceWith rising interest in over-the-counter (OTC) hearing aids as an alternative to traditional audiologist-fit devices, understanding their long-term efficacy is crucial. However, given the novelty of the US Food and Drug Administration category of OTC hearing aids, minimal evidence currently supports their long-term efficacy.ObjectiveTo compare the long-term self-reported outcomes at 8 months of self-fit OTC hearing aids to the same hearing aids fit by audiologists.Design, Setting, and ParticipantsBuilding on a previous randomized clinical trial, this follow-up comparative effectiveness research study reassessed a number of the original participants that were not lost to follow-up. Participants were initially divided into those with self-fit OTC hearing aids and those with audiologist-fit devices. Approximately 8 months after fitting, participants completed self-reported questionnaires. Missing data were addressed through multiple imputation. The original noninferiority trial was conducted at the University of Pretoria in South Africa from April 2022 to August 2022. The current analysis took place between July 7, 2023, to November 20, 2023.InterventionsIn the original trial, participants in the self-fit device group received a pair of OTC hearing aids and independently fit them with remote support as needed. The audiologist-fit device group received the same hearing aids fit by a certified audiologist using best practices.Main Outcomes and MeasuresThe main outcomes were self-reported hearing aid benefit, measured using the Abbreviated Profile of Hearing Aid Benefit (APHAB) and the International Outcome Inventory for Hearing Aids (IOI-HA).ResultsOf 64 participants in the trial, 44 participants were included in the extension study (21 [47.7%] in the audiologist-fit group; 23 [52.3%] in the self-fit group). The mean (SD) age of these participants was 63.0 (13.2) years, and 21 (47.7%) were male. At the long-term follow-up, self-fit and audiologist-fit groups showed no significant differences in the APHAB global score (mean difference, 0.02 [95% CI, −7.1 to 7.1]; Cohen d, 0.01 [95% CI, −0.5 to 0.5]) or the IOI-HA total score (mean difference, 1.5 [95% CI, −1.4 to 4.4]; Cohen d, 0.3 [95% CI, −0.2 to 0.8]). From 6 weeks to 8 months, no clinically meaningful group-time interaction was found between groups for the APHAB global score (Cohen d, 0.1 [95% CI, −0.2 to 0.3]), but a significant interaction for the IOI-HA total score was found (Cohen d, −0.6 [95% CI, −0.8 to −0.3]), with the self-fit group generally performing better.ConclusionThis comparative effectiveness research study demonstrated that self-fit OTC hearing aids can offer comparable long-term benefits to audiologist-fit hearing aids for individuals with mild to moderate hearing loss.