bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between liver fibrosis scores and short-term clinical outcomes in hospitalized chronic kidney disease patients: a prospective observational study
Authors: Das Dhriti Sundar , Anupam Anurag , Saharia Gautom Kumar 
Published: August 2024

IntroductionIn resource-constrained countries, inadequate access to healthcare and prognostic tools can be the Achilles’ heel in effectively managing chronic kidney disease (CKD). There is a significant similarity in the pathogenesis of CKD and liver fibrosis. The role of liver fibrosis (LF) scores in predicting short-term clinical outcomes in hospitalized patients with CKD is unknown. Our study aimed at calculating LF scores and studying the association of liver fibrosis with short-term mortality and morbidity in CKD patients.MethodsPatients aged above 15 years diagnosed with CKD as per the KDIGO criteria were enrolled. LF scores, namely, NFS, GPRI, and FIB-4 scores were calculated. Patients were followed up for a period of 28 days for good and poor composite outcomes, namely, the requirement of hemodialysis, non-invasive ventilation, prolonged hospital stay, and neurological and cardiovascular outcomes including death.ResultsAmong 163 patients, 70.5% were below 60 years of age, 82.2% were male and 35% were diabetic. At 28-day follow up, 52.1% had poor composite outcome. The AUROC for GPRI and FIB-4 in predicting poor outcomes was 0.783 (95% CI: 0.71–0.855) (p &lt; 0.001) and 0.62 (95% CI: 0.534–0.706) (p = 0.008), respectively. The AUROC for GPRI and NFS in predicting all-cause mortality was 0.735 (95% CI: 0.627–0.843) (p = 0.001) and 0.876 (95% CI, 0.8–0.952) (p &lt; 0.001), respectively.ConclusionWe found a positive association between LF scores and CKD outcomes in hospitalized patients. The LF scores significantly predicted poor outcomes in patients with CKD. Among the scores, GPRI was found to be a stronger predictor in predicting outcomes in both diabetic and non-diabetic patients with CKD. A high GPRI score was also associated with poor outcomes and increased mortality in both diabetics and non-diabetics.
Cocaine amphetamine-regulated transcription peptide inhibits apoptosis in oxygen–glucose deprived neural stem cells
Authors: Zhang Lu , Chen Shan , Zou Renfang , Shu Xin , Zhang Jingxuan , He Xuan , Su Moxi , Wang Luna , Wang Bin , Sha Dujuan 
Published: August 2024

BackgroundApoptosis has been recognized as a critical pathophysiological process during cerebral ischemia. The neuroprotective effect of CART on ischemic brain injury is determined. However, there is little research on the protective effect of CART on neural stem cells (NSCs).MethodsPrimary cultured rat NSCs were utilized as the research subject. In vitro oxygen glucose deprivation (OGD) treatment was employed, and NSCs were extracted from SD pregnant rats following previous experimental protocols and identified through cell immunofluorescence staining. The appropriate concentration of CART affecting OGD NSCs was initially screened using Cell Counting Kit-8 (CCK-8) and Lactate Dehydrogenase (LDH) assays. EdU staining and Western blotting (WB) techniques were employed to assess the impact of the suitable CART concentration on the proliferation and apoptosis of OGD NSCs. Finally, Western blot analysis was conducted to investigate the cAMP-response element binding protein (CREB) pathway and expression levels of related proteins after KG-501 treatment in order to elucidate the mechanism underlying apoptosis and proliferation regulation in OGD NSCs.ResultsCCK-8 and LDH assays indicated that a concentration of 0.8 nM CART may be the optimal concentration for modulating the proliferation of OGD NSCs. Subsequently, cellular immunofluorescence and EdU detection experiments further confirmed the findings obtained from CCK-8 analysis. Western blot analysis of apoptosis-related protein expression also demonstrated that an appropriate concentration of CART could suppress the apoptosis of OGD NSCs. Finally, Western blotting was conducted to examine the CREB pathway and related protein expression after treatment with KG-501, revealing that an appropriate concentration of CART regulated both apoptosis and proliferation in OGD NSCs through CREB signaling.ConclusionThe concentration of CART at 0.8 nM may be deemed appropriate for inhibiting apoptosis and promoting proliferation in OGD NSCs in vitro. The mechanism maybe through activating the CREB pathway.
Trisomy 8 presentation by inflammatory manifestations and its response to thalidomide: two case reports and narrative review
Authors: Zhang Xiaohua , Zhao Yan , Pan Yuting , Jin Jing , Fan Zhidan , Yu Haiguo 
Published: August 2024

ObjectiveIt has been recognized that there is a nexus among Trisomy 8 (T8), Behcet's disease (BD), and myelodysplastic syndrome (MDS). We reported a series of inflammatory features in 2 children with T8 without hematological involvement.Methods2 children with trisomy 8 who were excluded from MDS were retrospectively collected from the Department of Rheumatology and Immunology, Children's Hospital of Nanjing Medical University, Nanjing.ResultsPatients developed a range of inflammatory manifestations before a diagnosis of T8. The clinical manifestations of T8 patients vary from normal to severely disabled. Glucocorticoids and thalidomide can effectively relieve inflammation in patients with T8.ConclusionThe early clinical manifestations of T8 in children lack specificity, and the diagnosis is mainly based on karyotype analysis, gastrointestinal endoscopy and bone marrow aspiration findings. Active and effective immunoregulatory therapy and long-term follow-up can improve the prognosis of patients with T8.
Radiological evaluation of response in patients with locally advanced/metastatic soft tissue sarcoma treated with trabectedin
Authors: Ceddia S. , Onesti C. E. , Vari S. , Torchia A. , Cosimati A. , Riva F. , Maccallini M. T. , Cerro M. , Benvenuti G. , Russillo M. , Anelli V. , Sperduti I. , Biagini R. , Ferraresi V. 
Published: August 2024

Background: Trabectedin is an antineoplastic drug approved for patients (pts) with advanced soft tissue sarcomas (STS). Interestingly, the radiological evaluation of response during trabectedin therapy is peculiar.Methods: The aim of this single-center retrospective study is to analyze the concordance of response assessment according to RECIST compared with Choi criteria in patients with STS treated with trabectedin between 2009 and 2020 at Regina Elena National Cancer Institute in Rome.Results: We present the preliminary data collected in the last 2 months (mos) on 37 pts who received the diagnosis between 2015 and 2020, with a median age of 52.5 years (range 32–78). The median number of trabectedin cycles administered was four (range 2–50) for a median follow up of 5.83 months (range 1–60). Histological subtypes of STS were five (13.5%) leiomyosarcoma, 14 (37.8%) liposarcoma, nine (24.3%) undifferentiated pleomorphic sarcoma, three (8.1%) synovial sarcoma, and six (16.2%) other rare histological subtypes. Eight pts (21.6%) received trabectedin in the first line setting, 21 (56.8%) in the second line, and seven (18.9%) received it in subsequent lines. One pt received trabectedin as neoadjuvant therapy in a clinical trial (ISG-STS 1001). Median progression-free survival was 3.6 months (CI95% 2.7–4.6); median overall survival was 34.3 months (CI95% 0–75.4). The radiological responses were evaluated with both RECIST and Choi criteria; responses matched in 33 pts (89.2%) but not in four (10.8%). The best responses obtained according to RECIST criteria were two (5.4%) partial response (PR), 13 (35.1%) stable disease (SD), and 22 (59.5%) progressive disease (PD). Instead, two (5.4%), 13 (35.1%), and 22 (59.5%) pts obtained PR, SD, and PD respectively, according to Choi criteria. Cohen’s kappa coefficient of concordance was 0.792 (p-value &lt;0.002). A specialized radiologist performed all imaging examinations using a dedicated workstation in the same center.Conclusion: In this first analysis, the concordance between RECIST and Choi assessments demonstrates no statistically significant difference. Responses did not match for four pts. We are expanding the analysis to all pts included in the original cohort to confirm or deny these initial results.
Ocular adverse events associated with antibody-drug conjugates in oncology: a pharmacovigilance study based on FDA adverse event reporting system (FAERS)
Authors: Mao KaiLi , Chen Ping , Sun HuaYu , Zhong SongYang , Zheng HongLiang , Xu LuYao 
Published: August 2024

BackgroundAntibody-drug conjugates (ADCs) have emerged as the focus and hotspots in the cancer field, yet the accompanying ocular toxicity has often been underestimated. We aimed to comprehensively and comparatively analyze the risk of ocular toxicity associated with various ADCs using the FDA Adverse Event Reporting System (FAERS) database.MethodsData were extracted from the FAERS database from Q3 2011 to Q3 2023. We analyzed the clinical characteristics of ADCs-related ocular adverse events (AEs). These data were further mined by proportional analysis and Bayesian approach to detect signals of ADCs-induced ocular AEs. Moreover, the time to onset of ocular toxicity was also evaluated.ResultsA total of 1,246 cases of ocular AEs were attributed to ADCs. Ocular toxicity signals were observed in patients treated with belantamab mafodotin, brentuximab vedotin, enfortumab vedotin, mirvetuximab soravtansine, sacituzumab govitecan, trastuzumab deruxtecan, and trastuzumab emtansine. Of these, belantamab mafodotin, trastuzumab emtansine, and mirvetuximab soravtansine, whose payloads are microtubule polymerization inhibitors, were more susceptible to ocular toxicity. The ten most common ADCs-related ocular AEs signals are keratopathy [ROR = 1,273.52, 95% CI (1,129.26–1,436.21)], visual acuity reduced [ROR = 22.83, 95% CI (21.2–24.58)], dry eye [ROR = 9.69, 95% CI (8.81–10.66)], night blindness [ROR = 259.87, 95% CI (228.23–295.89)], vision blurred [ROR = 1.78, 95% CI (1.57–2.02)], photophobia [ROR = 10.45, 95% CI (9.07–12.05)], foreign body sensation in eyes [ROR = 23.35, 95% CI (19.88–27.42)], ocular toxicity [ROR = 144.62, 95% CI (117.3–178.32)], punctate keratitis [ROR = 126.21, 95% CI (101.66–156.69)], eye disorder [ROR = 2.71, 95% CI (2.21–3.32)]. In terms of onset time, sacituzumab govitecan displayed an earlier onset of 21 days, while trastuzumab deruxtecan exhibited the latest onset of 223 days.ConclusionADCs may increase the risk of ocular toxicity in cancer patients, leading to serious mortality. With the widespread application of newly launched ADCs, combining the FAERS data with other data sources is crucial for monitoring the ocular toxicity of ADCs. In addition, novel ocular toxicity signals not documented in product labeling were detected. Further research will be necessary to validate our findings in the future.
Nanoscale temperature sensors based on MIM waveguide coupling and ring-embedded nanostructures
Authors: Chen Hongfu , Yan Shubin , Cao Yuhao , Jiang Wen , Yan Xiaoran , Wang Chong , Liu Guang , Xu Aiwei , Wu Taiquan , Li Yuntang 
Published: August 2024

This study presents a novel refractive index sensor based on Fano resonance, incorporating a metal-insulator-metal (MIM) waveguide coupled with a circular ring structure (CRC). Using finite element method analysis, we investigated the propagation properties of the sensor. To evaluate their influence on sensor performance, we systematically varied the parameters of each Circular Resonant Cavity structure component, including the refractive index, employing a controlled variable approach. At its optimal configuration, the sensor achieves a maximum sensitivity of 3,240 nm/RIU and a figure of merit (FOM) of 57.9. With its high sensitivity, straightforward design, and suitability for temperature detection, the refractive index sensor holds promise for diverse applications.
Calcium lignosulfonate-induced modification of soil chemical properties improves physiological traits and grain quality of maize (Zea mays) under salinity stress
Authors: Alhaj Hamoud Yousef , Shaghaleh Hiba , Zhang Ke , Okla Mohammad K. , Alaraidh Ibrahim A. , AbdElgawad Hamada , Sheteiwy Mohamed S. 
Published: August 2024

IntroductionSalinity negatively affects maize productivity. However, calcium lignosulfonate (CLS) could improve soil properties and maize productivity.MethodsIn this study, we evaluated the effects of CLS application on soil chemical properties, plant physiology and grain quality of maize under salinity stress. Thus, this experiment was conducted using three CLS application rates, CLS0, CLS5, and CLS10, corresponding to 0%, 5%, and 10% of soil mass, for three irrigation water salinity (WS) levels WS0.5, WS2.5, and WS5.5 corresponding to 0.5 and 2.5 and 5.5 dS/m, respectively.Results and discussionResults show that the WS0.5 × CLS10 combination increased potassium (K 0.167 g/kg), and calcium (Ca, 0.39 g/kg) values while reducing the sodium (Na, 0.23 g/kg) content in soil. However, the treatment WS5.5 × CLS0 decreased K (0.120 g/kg), and Ca (0.15 g/kg) values while increasing Na (0.75 g/kg) content in soil. The root activity was larger in WS0.5 × CLS10 than in WS5.5 × CLS0, as the former combination enlarged K and Ca contents in the root while the latter decreased their values. The leaf glutamine synthetase (953.9 µmol/(g.h)) and nitrate reductase (40.39 µg/(g.h)) were higher in WS0.5 × CLS10 than in WS5.5 × CLS0 at 573.4 µmol/(g.h) and 20.76 µg/(g.h), leading to the improvement in cell progression cycle, as revealed by lower malonaldehyde level (6.57 µmol/g). The K and Ca contents in the leaf (881, 278 mg/plant), stem (1314, 731 mg/plant), and grains (1330, 1117 mg/plant) were greater in WS0.5 × CLS10 than in WS5.5 × CLS0 at (146, 21 mg/plant), (201, 159 mg/plant) and (206, 157 mg/plant), respectively. Therefore, the maize was more resistance to salt stress under the CLS10 level, as a 7.34% decline in yield was noticed when salinity surpassed the threshold value (5.96 dS/m). The protein (13.6 %) and starch (89.2 %) contents were greater in WS0.5 × CLS10 than in WS5.5 × CLS0 (6.1 %) and (67.0 %), respectively. This study reveals that CLS addition can alleviate the adverse impacts of salinity on soil quality and maize productivity. Thus, CLS application could be used as an effective soil amendment when irrigating with saline water for sustainable maize production.
Acceptance and commitment coaching for music performance anxiety in adolescent singers
Authors: Paul Anupa Elizabeth , Juncos David G. , Winter Debbie 
Published: August 2024

IntroductionMost of the anxiety disorders, particularly social anxiety, seem to develop either during childhood or adolescence. Adolescent singers who experience physical, mental and emotional changes along with voice change are particularly prone to the development of MPA. However, adolescence also seems to be an opportune time to instil healthy behaviours in singing students as they are more likely to remember these coping strategies, owing to the release of dopamine and the ‘reminiscence bump’. As this period of a singer’s life is wrought with inevitable anxiety development, the additional aim of the study was to develop a coaching framework which can be used by singing teachers in their practice. Mindset training for adolescents seems crucial to help them continue singing through puberty so they do not drop out of singing lessons or choir during voice change and identity development.MethodsThe study aimed to determine if Acceptance and Commitment coaching could be used with adolescent singers with MPA and to record and analyse rich qualitative data in the form of semi-structured participant interviews and questionnaires.ResultsWhen their perception of MPA symptoms and physiological and psychological arousal before a performance changed, their behaviour and reactions changed accordingly. The change took place over a period of time, which was characterised by discoveries about themselves, confusion in understanding new concepts and letting go of old habits. Interestingly, by the end of the coaching sessions, their preoccupation with pleasing the audience and appearing perfect on stage was replaced by a new-found delight in pursuing values and goals related to their singing. Along with this came the acceptance of themselves and others as individuals with the potential for growth and change and the capacity to learn from mistakes.DiscussionThis study marks the first investigation into the effectiveness of using of ACC as an intervention for MPA in adolescent singers undergoing puberty by a singing teacher. The results are promising and suggest that ACC is an effective MPA intervention for adolescent singers to cope with inevitable development-related anxieties and keep them engaged in the activity of singing during their pubertal years.
Questioning evidence-based practice in physiotherapy: a philosophical reflection. The example of physiotherapy with musicians
Authors: Rousseau Céleste , Stiegler Barbara 
Published: August 2024

IntroductionIn the late 1990s, evidence-based medicine (EBM) emerged, emphasizing the conscientious use of current best evidence in medicine and ensuring the best care for each individual. Thus, applying evidence-based practice (EBP) in physiotherapy is complex due to sparse research, distinct challenges, and unsuitable tools. This is particularly relevant considering musicians’ health since the literature is very limited.Part IThe first part advocates for EBP and explain how it ensures both the best care and adherence to ethical principles (beneficence, non-maleficence, respect for autonomy, and justice), for both caregivers and patients.Part IIThe second part discusses the common pitfalls often encountered by healthcare professionals, and especially as physiotherapists for musicians, when applying evidence at the patient’s bedside, again from both perspectives, healthcare professionals and patients.Part IIIFinally, this third part aims to open the discussion by considering various perspectives, such as values-based practice or the importance of qualitative research, to reshape EBP in physiotherapy.ConclusionThis work highlights the prevalent existence of grey zones encountered by healthcare practitioners with musicians. While conducting more research to help understand them, physiotherapists must learn to navigate these waters.
The impact of family factors and digital technologies on mental health in university students
Authors: Gandarillas Miguel Ángel , Elvira-Zorzo María Natividad , Pica-Miranda Gabriela Alicia , Correa-Concha Bernardita 
Published: August 2024

IntroductionA substantial body of research indicates an increasing prevalence of mental health issues among university students in a range of countries. A number of psychosocial factors have been put forward in the research literature as possible explanations for this persistent decline in psychological wellbeing in higher education. The present study focused on the role of family factors and the use of digital technologies by students.MethodsA replication study was conducted at the University of the Americas (Chile) based on a previous study on psychosocial factors of academic learning patterns and mental health of university students at the Complutense University of Madrid (UCM), Spain. A cross-sectional design was employed, using the same questionnaire, plus indicators of most frequently used digital technologies by the students. The questionnaire was administered online at the same time to all incoming students, gathering a sample of 4,523 students. A series of multiple regressions and ANOVAs was conducted to ascertain the extent to which family and digital factors could be identified as predictors of mental health indicators.ResultsThe most significant findings indicate that high levels of parental protection and control/discipline, and especially the high use of social media and smartphones, are particularly salient factors contributing to mental health problems in the learning process of higher education students.DiscussionThe results suggest strategies to promote wellbeing, with a focus on the psychosocial diversity within an inclusive university community. Social and digital innovation, collective entrepreneurship, and participatory place-building may facilitate networks of artistic, cultural, ecological, and sports spaces to promote the sense of university community. A longitudinal follow-up on the same sample across academic years will reveal the extent to which these wellbeing initiatives are fruitful.
How is parental psychological control associated with adolescent mental health in economically disadvantaged areas? The serial mediating role of psychological reactance and problematic smartphone use
Authors: Li Qiangqiang , Wei Shuwen , Liu Zixiao 
Published: August 2024

IntroductionAdolescent mental health has been an issue of global concern, and the mental health of adolescents in economically disadvantaged areas may require additional research. The research delves into factors associated with economically disadvantaged areas’ adolescent mental health, employing family systems theory, self-determination theory, and psychological reactance theory. Specifically, the present study which was done in Jingzhou country, an economically disadvantaged area of Hunan Province, China, aimed to examine the link between parental psychological control and adolescent mental health, as well as the mediating roles of psychological reactance and problematic smartphone use in this relationship.MethodsA sample of 1300 Chinese middle school students (620 girls, mean age = 14.22 ± 1.29) completed self-reported measures of parental psychological control, psychological reactance, problematic smartphone use, and adolescent mental health.ResultsResults showed that parental psychological control was negatively associated with adolescent mental health. Psychological reactance and problematic smartphone use mediated the association between parental psychological control and adolescent mental health, separately and serially.DiscussionThe findings of the present study enrich the literature on parenting styles and adolescent mental health in economically disadvantaged areas, and this provides an intervention perspective to reduce the negative impact of poor parenting on adolescent mental health in economically disadvantaged areas.
Social environment, health cognition, and health behavior: how individuals with non-fixed employment end up with adverse health outcomes in China under the era of VUCA?—findings from PLS-SEM and fsQCA
Authors: Wei Haibin , Wang Qiaoqi , Chen Jianyang , Liang Zhenyi , Wu Yibo , Luo Hongye 
Published: August 2024

ObjectivesThis article studied the single-factor causal relationships between the social environment, health cognition, and health behavior of the individuals with non-fixed employment and their adverse health outcomes, as well as the complex causal relationships of multiple factors on these outcomes.MethodsPartial Least Squares Structural Equation Modeling (PLS-SEM) and Fuzzy-Set Qualitative Comparative Analysis (fsQCA) are employed. Data is collected from the results of an open questionnaire Psychology and Behavior Investigation of Chinese Residents 2021.ResultsPLS-SEM analysis reveals that health risk behaviors and cognition play a mediating role in impact of the social environment on adverse health outcomes, indicating that individuals with non-fixed employment susceptible to adverse health outcomes. fsQCA analysis identifies that weak social support is a core condition leading to outcomes of depression and anxiety. There are shared configurations and causal pathways between the outcomes of physical health and depression.ConclusionThe study supports the social determinants theory of health and suggests that the fundamental reason for people being trapped in adverse health outcomes is the health inequality caused by social stratification, and the external shock of uncertainty in the era of VUCA (Volatility, Uncertainty, Complexity, and Ambiguity).