bluuebunny/crossref_metadata_2025_split huggingface dataset:
VALIDASI METODE PENETAPAN KADAR METFORMIN DALAM PLASMA DARAH YANG DIBERIKAN BERSAMAAN DENGAN PEMBERIAN SARI BUAH PARE (Momordica charantia L.) SECARA KROMATOGRAFI CAIR KINERJA TINGGI (KCKT)
Authors: Fernando Armon , Putri Nurafika Kurniawan , Fadhli Haiyul 
Published: August 2024

Pada penelitian ini telah dilakukan validasi metode penetapan kadar metrofmin dalam plasma darah manusia yang diberikan bersamaan dengan sari buah pare (Momordica charantia L.) secara Kromatografi Cair Kinerja Tinggi (KCKT). Sari buah pare juga memiliki senyawa mebalit sekunder yang dapat mempengaruhi analisis metformin di dalam darah. Tujuan dari penelitian ini adalah untuk mendapatkan metode yang valid untuk penetapan kadar metformin terhadap pemberian sari buah pare dalam plasma manusia secara in vitro menggunakan KCKT dengan detektor UV menggunakan glibenklamid sebagai internal standard. Sistem KCKT menggunakan fase terbalik dengan kolom VP-ODS C-18, panjang kolom 5 µm, 4,6 x 150 mm. Fase gerak yang di gunakan dengan komposisi metanol:air (SDS 3 mM) pH 3 dengan phosporic acid (60:40) dengan kecepatan alir 1 mL/menit dan dideteksi pada panjang gelombang 226 nm. Berdasarkan hasil penelitian didapat nilai LOD sebesar 0,24 ppm dan nilai LOQ sebesar 0,8 ppm dari persamaan regresi y=0,0184x+0,0726 dengan koefisien korelasi (R2) 0,9979. Hasil uji akurasi tidak memenuhi persyaratan yaitu persen uji perolehan kembali tidak kurang dari 80% dan tidak lebih dari 120%, sedangkan hasil uji presisi telah memenuhi persyaratan dengan nilai persen koefisien variasi tidak lebih dari 20%.
In this study, validation of method for determining metrofmin levels in human blood plasma given together with bitter melon juice (Momordica charantia L.) has been performed using High Performance Liquid Chromatography (HPLC). Bitter melon juice also has secondary metabolites which can affect the analysis of metformin in the blood. The aim of this research is to obtain a valid method for determining metformin levels when administering bitter melon juice in human plasma in vitro using HPLC with a UV detector using glibenclamide as an internal standard. The HPLC system uses reverse phase with a VP-ODS C-18 column, column length 5 µm, 4.6 x 150 mm. The mobile phase used was a composition of methanol: water (SDS 3 mM) pH 3 with phosphoric acid (60:40) with a flow speed of 1 mL/minute and detected at a wavelength of 226 nm. The research results obtained an LOD value of 0.24 ppm and a LOQ value of 0.8 ppm from the regression equation y=0.0184x+0.0726 with a correlation coefficient (R2) of 0.9979. The results of the accuracy test do not meet the requirements, namely the percent recovery test is not less than 80% and not more than 120%, while the precision test results meet the requirements with a percent coefficient of variation value of not more than 20%.
SUMBER POTENSIAL AGEN ANTIINFLAMASI TANAMAN INDONESIA DARI USADA TARU PREMANA DAN PERKEMBANGAN FORMULASINYA: TELAAH PUSTAKA
Authors: Buana Komang Dirga Mega , Mauludin Rachmat 
Published: August 2024

Peradangan atau inflamasi merupakan salah satu respon tubuh terhadap kerusakan jaringan, kontak dengan zat asing, respon imun, maupun salah satu akibat dari trauma fisik. Inflamasi merupakan gejala umum yang sering terjadi pada beberapa penyakit. Penggunaan obat antiinflmasi steroid dan non-steroid merupakan alternative yang umum digunakan, akan tetapi penggunaannya diketahui menimbulkan efek samping merugikan bagi tubuh. Hal ini mendorong banyak penelitian mengenai pengobatan alternatif lain dari tumbuhan obat. Salah satu contoh yang menarik dibahas yaitu tanaman tradisional khas Bali yang tertulis dalam Usada Taru Premana (naskah medis kuno yang ada di Bali). Pada artikel ini akan dibahas mengenai rangkuman beberapa tanaman khas Bali yang terbukti khasiatnya sebagai agen anti-inflamasi melalui pengujian in vitro dan in vivo. Penelitian ini menggunakan studi literatur yang mengumpulkan data dan informasi dari mesin pencarian seperti PubMed, Google Cendekia dengan kata kunci (herbal, ekstrak, tanaman obat, inflamasi, taru premana) atau dan basis data ilmiah. Hasil rangkuman menyatakan bahwa kandungan metabolit sekunder alkaloid, flavonoid, dan senyawa fenolik merupakan senyawa yang banyak bertanggung jawab dalam efektivitas tumbuhan obat sebagai agen anti-inflamasi.
Single Parent Efforts in Meeting Family Economic Needs in Bubu Village, Kambowa District, North Buton Regency
Authors: Siti Rosmaladewi  , Darmin Tuwu  , Amin Tunda  
Published: August 2024

The purpose of the study is to find out how the efforts of single parents in fulfilling the exit economy of a single parent in Bubu Village, and to find out what are the supporting and inhibiting factors in an effort to meet the economic needs of the family in Bubu Village, Kambowa District, North Buton Regency. This type of research uses a qualitative approach with a problem study method to 8 single parents in Bubu Village.The data collection technique uses interview, observation, and documentation methods. Data analysis uses approaches, namely: data collection, data reduction, data presentation, and conclusion drawn. The results of this study show the efforts of single parents in meeting the economic needs of families in Bubu Village/sub-district, Kambowa District, North Buton, namely 1. Work, 2. Expecting help from family, 3. Expect help from the government. The supporting factors for single parent efforts to meet the economic needs of the family are, 1. Motivation and encouragement from the family. The factors that hinder single parent efforts in meeting the economic needs of the family are, 1. Limited skills, 2. Limited infrastructure, 3. There is no help from the husband in meeting the needs of the family
Implementation of Skill Learning in Self-Development of Visually Handicapped Children (Study at Kusuma Bangsa Extraordinary School, Kendari City)
Authors: Nurfitriani  , Juhaepa  , Megawati Asrul Tawulo  
Published: August 2024

This study aims to determine the components of skill learning and the implementation of skill learning for self-development of children with disabilities at Kusuma Bangsa Extraordinary School. This type of research uses a qualitative research approach. The determination of informants in this study uses the Purposive Sampling method so that the informants are teachers and children with disabilities The data sources used in this study are Primary and Secondary Data. The data collection techniques used are observation, interview, and documentation methods. The data analysis technique uses a qualitative approach through qualitative descriptive analysis. The results of this study show that skill learning for children with disabilities has a well-organized structure. The goal is to train students' independence and entrepreneurship. The learning components include objectives, educators, learners, materials, methods, media, and evaluation. Implementation is carried out once a week with three stages: beginning, core, and end. The method used is hands-on practice, with materials from the internet and media in the form of necessary tools and materials. Evaluation is carried out through oral questions after learning. Although only two teachers are in primary charge, other teachers help in implementation. This learning is tailored to children's interests, demonstrating a student-centred approach in developing practical skills for students' futures
Rancang Bangun Sistem Informasi Repository dengan Mengunakan Metode WaterFall di IKesT Muhammadiyah Palembang
Authors: Paray Theo Lonando  , A. Firdaus  , Ridwan Hakim  
Published: August 2024

Pemanfaatan information technology segala bidang merupakan sebuah keharusan untuk membantu dalam kegiatan operasionalnya dalam pengolahan data secara cepat dan tepat. Setiap laboratorium kesehatan IKesT Muhammadiyah Palembang memiliki aset berupa barang ataupun peralatan guna mendukung kegiatan praktikum dan proses belajar sistem laboratorium. Disetiap semester perkuliahan akan diadakan kegiatan praktikum untuk beberapa mata kuliah dan akan selalu melibatkan asisten laboratorium untuk mempersiapkan dan mengajar praktikum .dimana proses peminjamannya masih manual. Aplikasi adalah suatu subkelas perangkat lunak komputer yang memanfaatkan kemampuan komputer langsung untuk melakukan suatu tugas yang diinginkan pengguna. penulis akan membangun sebuah sistem peminjaman barang dan peralatan pada Unit Pengelolah laboraturium IKesT Muhammadiyah Palembang menggunakan aplikasi Desktop dengan menggunakan Laravel 8
Power Failure: Appearance and Change in Badiou’s Logics of Worlds
Authors: Dawson Joshua Avery 
Published: August 2024

ABSTRACT
Where Being and Event was a book of meta-ontology, demonstrating how things be, Alain Badiou tells us that Logics of Worlds is an objective phenomenology demonstrating how (and what) things do. As such, it should also be considered a book about power: how objects function in their worlds, how change is possible, and what the event does to worlds and the objects in them. Attending to this, this article shows two conflicting forms of power emerge in Logics of Worlds, the power of appearance and the power of change. In this article, the author argues their incommensurability suggests an overall failure of a consistent account of power from Badiou.
Prometheus Underground: Probing the Scientist in Depth as the Carnal First Act of French Phenomenology with Arnaud Dandieu and Claude Chevalley
Authors: Roy Christian 
Published: August 2024

ABSTRACT
Arnaud Dandieu (1897–1933), a Personalist transdisciplinary thinker, joined up with Claude Chevalley (1909–84), cofounder of the Bourbaki group of mathematicians, to conduct a phenomenological study of the scientist’s activity over several articles. It shows the current development of “carnal hermeneutics” already present among the earliest manifestations of French phenomenology, in a tactile approach to the sense of depth as key to the search for knowledge, from the sorcerer to the scientist, building on the phenomenological psychology of Eugène Minkowski (1885–1972). Dandieu and Chevalley’s “rational act of exclusion” takes the irrational concrete as the fulcrum of a heroic psychological breakthrough to purely logical abstraction, inseparable from its existential ground in embodied personhood. The present article will use their little-known articles to document the conscious emergence of a distinctly French school of phenomenology, eschewing from the start, twenty years before Merleau-Ponty, the neglect of multisensory experience in the flesh decried by critics of its German tradition.
The Terror of the Foundation in Santiago Castro-Gómez’s Political Philosophy: A Critique of Political Ontology
Authors: Acuña Julian Rios 
Published: August 2024

ABSTRACT
This article problematizes Santiago Castro-Gómez’s rupture with genealogy in favor of normative political philosophy. This rupture is characterized by a turn toward a political ontology that transforms political concepts into ontological categories that allow Castro-Gómez to posit a category of “the marginalized” as the ultimate foundation of political normativity. Through a dialogue with Frank Wilderson and Frantz Fanon, this article argues that such an ontologization of political categories, Castro-Gómez’s political ontology, leads to the reinscription of a colonial foundationalist logic of the terror of exclusion and leads Castro-Gómez to erase the specificity of incommensurable struggles and to constrain political imagination.
Unlearning Pauline Messianism: Prophetic Study and Historical Injustice in Walter Benjamin and Hermann Cohen
Authors: Hay Natasha 
Published: August 2024

ABSTRACT
This article argues against Giorgio Agamben’s use of Paul’s Epistles to align Walter Benjamin’s critique of violence with antinomian theology and anarcholibertarian politics. It focuses specifically on Benjamin’s critical inheritance of Hermann Cohen’s concepts of unintentional sin and atonement to show that he reactivates a prophetic register of education in Jewish religious ethics. The article contends that these normative and narrative elements of Talmud Torah refute a reductive view of Jewish legalism in confronting the cultural afterlives of historical violence. This argument not only uncouples the reception of Benjamin’s theopolitics from contemporary continental philosophy’s revivals of Pauline messianism, but also contributes to a plural field of political theology emerging beyond the scope of secularized concepts of governance derived from a spurious universalism. This article proposes that the nonidentity between human law and divine justice can orient necessary resistance to justifications for and acts of state violence committed in a community’s name.
Primitive Speculation: Marx on Precapitalism, Social Relations to Land, and Indigenous Dispossession
Authors: Wapeemukwa Wayne 
Published: August 2024

ABSTRACT
Marx studied how capitalism changes relations to land before and after Capital—but wielded different methodologies and reached different conclusions. In Grundrisse, Marx investigates precapitalism from a speculative standpoint. In Capital, Marx provides a selective and historical description of dispossession but delimits his analysis to Western Europe. Post-Capital, Marx wields Henry Lewis Morgan’s anthropology and Justus von Liebig’s ecology as scientific bases upon which to critique capitalist property relations. Specifically, Marx believed that the capitalist mode of production installed a historically specific relation to land; and that this relation was abstract, accumulative, and proprietorial. This article shows that Marx began to develop a critical theory of dispossession that overspills the historical, metaphysical, and developmental sequencing usually attributed to him. This late Marx believes that Indigenous peoples have a concrete, metabolic, and communal relationship to the land that communism must recapitulate and rehabilitate; this thesis has been misunderstood by readers of Marx, who impose an overly historicized interpretation upon his work.
La presunta controversia tra Pascasio e Ratramno in epoca carolingia: alle origini della razionalizzazione della dottrina eucaristica
Authors: Ventura Raffaele Alberto 
Published: August 2024

L’articolo si concentra su uno snodo centrale nella lunga crisi che tocca la dottrina eucaristica nel Medioevo, ovvero sulla presunta controversia tra Pascasio Radberto e Ratramno di Corbie nel IX secolo a proposito della presenza di Cristo nel sacramento, in figura oppure in verità. Partendo dalla constatazione che le visioni dei due monaci non sono contrapposte, come si è creduto a partire dal X-XI secolo, intendiamo innanzitutto mostrare che i loro sono tentativi complementari di ritradurre entro categorie chiare e univoche una dottrina patristica caratterizzata dalla sua indeterminatezza. Per spiegare l’origine di questa esigenza di chiarificazione, mostreremo come il contesto corbiense sia stato permeato dall’influenza del primo rientro dell’aristotelismo (la logica vetus) sulla base di un più ampio programma carolingio di modernizzazione della società e di razionalizzazione della dottrina. La crisi eucaristica, di cui a Corbie si vedono le prime avvisaglie, appare quindi come una faticosa contrattazione sul significato della dottrina patristica al fine di conservare un equilibrio tra simbolismo e realismo, resasi necessaria come effetto di un cambio di paradigma logico-ontologico pur di preservare l’unità della fede e quindi della comunità cristiana. Questa crisi si chiuderà solo con la dottrina della transustanziazione, al termine di un lungo processo di razionalizzazione preso in carico da una classe di tecnici della teologia.

The paper focuses on a central juncture in the long crisis that touches Eucharistic doctrine in the Middle Ages, namely the alleged dispute between Paschasius Radbertus and Ratramnus of Corbie in the ninth century regarding the presence of Christ in the sacrament: in figure or in truth? Starting from the observation that the visions of the two monks are not opposed, as was believed from the 10th-11th centuries onward, we intend first to show that theirs are complementary attempts to translate within clear and unambiguous categories the vagueness of patristic doctrine. In order to explain the origin of this need for clarification, we show how the Corbian context was permeated by the influence of the first return of Aristotelianism (the logica vetus) on the basis of a broader Carolingian program of modernization of society and rationalization of doctrine. The Eucharistic crisis, the first signs of which can be seen in Corbie, thus appears as a bargaining over the meaning of patristic doctrine in order to preserve a balance between symbolism and realism, made necessary as the effect of a logical-ontological paradigm shift in order to preserve the unity of the faith and thus of the Christian community. This crisis will close only with the doctrine of transubstantiation, at the end of a long process of rationalization taken over by a class of experts of theology.
La testimonianza per sentito dire: percorso di una prova anomala fra <i>credulitas</i>, <i>veritas</i> e <i>necessitas</i>
Authors: Bassani Alessandra 
Published: August 2024

La testimonianza per sentito dire, nonostante la sua evidente inadeguatezza a fornire conoscenze certe sui fatti avvenuti, viene utilizzata nei processi penali fin dall’Alto Medioevo. Il saggio ripercorre la riflessione della scienza giuridica medievale, in particolare di Bartolo da Sassoferrato, sulla formazione del convincimento del Giudice, per offrire un contributo alla comprensione dei motivi dell’utilizzo di questo anomalo strumento di prova anche nel processo penale contemporaneo.

Hearsay evidence, despite its evident inadequacy to provide certain knowledge about the events that occurred, has been used in criminal trials since the Early Middle Ages. The essay traces the reflection of medieval legal science, in particular by Bartolo da Sassoferrato, on the formation of the Judge's conviction, to offer a contribution to understanding the reasons for the use of this anomalous evidence also in contemporary criminal trials.
Senso mistico e senso letterale nel <i>Commento a Giobbe</i> di Nachmanide
Authors: Savino Daniele 
Published: August 2024

Il Commento al Libro di Giobbe di Mosè Nachmanide rappresenta un ideale corollario antropologico ed escatologico al suo imponente Commento alla Torah. Esponente di spicco della comunità ebraica di Gerona e della locale scuola cabalistica, dove agli insegnamenti del provenzale Isacco il Cieco si associano elementi provenienti dalla tradizione talmudica, ellenistica e araba, Nachmanide propone una lettura esoterico-cabalistica di Giobbe volta a confutare l’apparente inconciliabilità ontologica tra l’esperienza del dolore individuale e l’ordine di un cosmo plasmato nella caligine demiurgica delle origini. Dopo aver spiegato, con linguaggio allusivo e in stile midrashico, la natura dell’anima e l’origine del male, Nachmanide mostra come la protesta di Giobbe, il giusto che apparentemente soffre ingiustamente, rappresenti una dissonanza destinata a risolversi nella superiore armonia del tutto: è questo il grande mistero dell’esistenza individuale, un mistero che riecheggia nel silenzio di Giobbe ammonito da Dio e che si svela unicamente a quegli iniziati che, come Elihu, critico di Giobbe e dei suoi tre amici, miopi consolatori, sono stati scelti quali depositari della più antica saggezza.
Nahmanides’ Commentary on the Book of Job constitutes an ideal anthropological and eschatological corollary of his monumental Commentary on the Torah. A leading figure of the Girona’s Jewish community and of its kabbalistic school, where the teachings of the Provençal master Isaac the Blind were enriched with elements of the Talmudic, Hellenistic and Arabic traditions, Nahmanides outlines a kabbalistic esoteric interpretation of Job designed to reject the seeming ontological irreconcilability between the individual experience of suffering and the ordered system of a universe forged in the demiurgic night of the origins. After explaining, in allusive language and midrashic style, the nature of human soul and the origin of evil, Nahmanides proves that Job’s protest, the protest of a just man suffering unjustly, is nothing but a dissonance destined to resolve itself into the superior harmony of the creation. This is the great mystery of individual existence, a mystery that echoes in the silence of Job, warned by God, and that unveils itself only to those initiates who, like Elihu critic of Job and of his three friends, who are merely short-sighted consolers, have been chosen as depositaries of the most ancient wisdom.
L’ordine alchemico del mondo. Cause naturali e intervento divino nella <i>Pretiosa Margarita Novella</i> di Pietro Bono da Ferrara
Authors: Tomatis Jacopo 
Published: August 2024

Fin dalle sue origini l’alchimia ha dovuto confrontarsi con il problema dell’ordine. La sua eccentricità rispetto agli altri saperi medievali poneva questioni sulla sua collocazione e sulla natura dell’oggetto che cercava, la pietra filosofale. L’articolo presenta il tentativo fatto dal medico Pietro Bono da Ferrara di riordinare la materia alchemica e di incasellarla nel sistema scientifico scolastico. Nella sua opera, la Pretiosa Margarita Novella, egli utilizza il sillogismo per ordinare la trattazione dell’alchimia, la subalternatio per definirla come una tra le scienze naturali e collocarla all’interno del sistema dei saperi e il concetto di forma specifica per descrivere la pietra filosofale e inserirla nel processo di generazione dei metalli. In questo modo Bono concepisce l’alchimia come una scienza che risponde a due ordini, quello naturale di generazione dei metalli, nel quale opera, e quello divino, al quale deve fare appello per trovare la pietra, che sono complementari tra loro, poiché hanno la loro origine in Dio.

Since its origins, alchemy has had to deal with the problem of order. His eccentricity compared to other medieval knowledge posed questions about his collocation and the nature of the object he was looking for, the philosopher’s stone. This article presents the attempt, made by the doctor Pietro Bono da Ferrara, to embed alchemy in the school scientific system. In his work, the Pretiosa Margarita Novella, he uses syllogism to order the treatment of alchemy, the subalternatio to place it within the system of sciences and the concept of forma specifica to describe the philosopher’s stone and insert it in metals’ generation process. In this way, Bono conceives alchemy as a science referring to two orders, the natural one of metal generation, in which it operates, and the divine one, to which he must appeal to find the philosopher’s stone, which are complementary to each other since they both have their origin in God.