bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperament Dispositions, Problematic Eating Behaviours and Overweight in Adolescents
Authors: Walther Mireille , Hilbert Anja 
Published: June 2015

AbstractObesity, a common health condition in adolescence leading to severe medical complications, is assumed to be influenced by temperament factors. This paper investigates associations between reactive and regulative temperament, problematic eating behaviours and excess weight. Several self‐report instruments were completed by 130 adolescents (mean age 14.13 ± 0.61 years), including 27 overweight and obese individuals (20.8%). Bootstrap analysis revealed a mediating effect of restrained eating on the relation between reactive temperament and body mass index percentile, which differed according to gender: Restrained eating, which predicted weight gain, was more present in girls having a higher sensitivity to reward and in boys showing a higher sensitivity to punishment. No effect of regulative temperament was found. These results have important implications for weight management programmes, as they suggest that reducing restrained eating by working on temperament may help to control weight. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
A preliminary study on diversity and distribution of Spirulina, Arthrospira and Glaucospira (Cyanobacteria) in the Brahmaputra Valley of Assam (India)
Authors: Baruah Partha Pratim , Baruah Rosaballe , Das Purabi 
Published: June 2015

AbstractSpirulina, a filamentous cyanobacterial genus, is one of the popular microorganisms for its use as food as well as medicine and in other industries. The present works deals with the diversity and distribution of the genus Spirulina, along with allied generaArthrospira and Glaucospira in Brahmaputra valley of Assam, a state located in North‐Eastern region of India. The region is sandwiched between Himalaya (eastern) and Indo‐Burma biodiversity hotspots and has been poorly explored by previous algal systematists and ecologists. During the present survey that was carried out from April 2011 to May 2012 in thirty four different geographical locations covering entire valley, a total of 6 species of Spirulina, 1 species each of Arthrospira and Glaucospira were identified. All are taxonomically characterized along with their habitat characteristics. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Disrupted functional connectivity of cerebellar default network areas in attention‐deficit/hyperactivity disorder
Authors: Kucyi Aaron , Hove Michael J. , Biederman Joseph , Van Dijk Koene R.A. , Valera Eve M. 
Published: June 2015

AbstractAttention‐deficit/hyperactivity disorder (ADHD) is increasingly understood as a disorder of spontaneous brain‐network interactions. The default mode network (DMN), implicated in ADHD‐linked behaviors including mind‐wandering and attentional fluctuations, has been shown to exhibit abnormal spontaneous functional connectivity (FC) within‐network and with other networks (salience, dorsal attention and frontoparietal) in ADHD. Although the cerebellum has been implicated in the pathophysiology of ADHD, it remains unknown whether cerebellar areas of the DMN (CerDMN) exhibit altered FC with cortical networks in ADHD. Here, 23 adults with ADHD and 23 age‐, IQ‐, and sex‐matched controls underwent resting state fMRI. The mean time series of CerDMN areas was extracted, and FC with the whole brain was calculated. Whole‐brain between‐group differences in FC were assessed. Additionally, relationships between inattention and individual differences in FC were assessed for between‐group interactions. In ADHD, CerDMN areas showed positive FC (in contrast to average FC in the negative direction in controls) with widespread regions of salience, dorsal attention and sensorimotor networks. ADHD individuals also exhibited higher FC (more positive correlation) of CerDMN areas with frontoparietal and visual network regions. Within the control group, but not in ADHD, participants with higher inattention had higher FC between CerDMN and regions in the visual and dorsal attention networks. This work provides novel evidence of impaired CerDMN coupling with cortical networks in ADHD and highlights a role of cerebro‐cerebellar interactions in cognitive function. These data provide support for the potential targeting of CerDMN areas for therapeutic interventions in ADHD. Hum Brain Mapp 36:3373–3386, 2015. © 2015 Wiley Periodicals, Inc.
Accelerated corpus callosum development in prematurity predicts improved outcome
Authors: Thompson Deanne K. , Lee Katherine J. , van Bijnen Loeka , Leemans Alexander , Pascoe Leona , Scratch Shannon E. , Cheong Jeanie , Egan Gary F. , Inder Terrie E. , Doyle Lex W. , Anderson Peter J. 
Published: June 2015

AbstractObjectivesTo determine: (1) whether corpus callosum (CC) size and microstructure at 7 years of age or their change from infancy to 7 years differed between very preterm (VP) and full‐term (FT) children; (2) perinatal predictors of CC size and microstructure at 7 years; and (3) associations between CC measures at 7 years or trajectories from infancy to 7 years and neurodevelopmental outcomes.Experimental designOne hundred and thirty‐six VP (gestational age [GA] <30 weeks and/or birth weight <1,250 g) and 33 FT children had usable magnetic resonance images at 7 years of age, and of these, 76 VP and 16 FT infants had usable data at term equivalent age. The CC was traced and divided into six sub‐regions. Fractional anisotropy, mean, axial, radial diffusivity and volume were measured from tractography. Perinatal data were collected, and neurodevelopmental tests administered at 7 years' corrected age.Principal observationsVP children had smaller posterior CC regions, higher diffusivity and lower fractional anisotropy compared with FT 7‐year‐olds. Reduction in diffusivity over time occurred faster in VP than FT children (P ≤ 0.002). Perinatal brain abnormality and earlier GA were associated with CC abnormalities. Microstructural abnormalities at 7 years or slower development of the CC were associated with motor dysfunction, poorer mathematics and visual perception.ConclusionsThis study is the first to demonstrate an accelerated trajectory of CC white matter diffusion following VP birth, associated with improved neurodevelopmental functioning. Findings suggest there is a window of opportunity for neurorestorative intervention to improve outcomes. Hum Brain Mapp 36:3733–3748, 2015. © 2015 Wiley Periodicals, Inc.
Groundwater mixing between different aquifer types in a complex structural setting discerned by elemental and stable isotope geochemistry
Authors: Murgulet Dorina , Cook Marlon , Murgulet Valeriu 
Published: June 2015

AbstractKarst aquifers are well known for their intricate stratigraphy and geologic structures, which make groundwater characterization challenging because flowpaths and recharge sources are complex and difficult to evaluate. Geochemical data, collected from ten closely spaced production wells constructed in two karst aquifers (Bangor Limestone (Mb) and Tuscumbia Limestone/Fort Payne Chert (Mftp)) in Trussville, north‐central Alabama, illustrate two distinctive groundwater end‐members: (1) higher major ion, dissolved inorganic carbon, conductivity, alkalinity concentrations, heavier δ13C ratios (max: −10.2 ± 0.2‰ Vienna Pee Dee Belemnite (PDB)) and lower residence times (mean: 19.5 ± 2 years, n = 2) of groundwater in the Mb aquifer and (2) lower constituent concentrations, lighter δ13C ratios (min: −13.4 ± 0.2‰ PDB) and longer residence times of groundwater (mean: 23.6 ± 2 years, n = 4) in the Mftp aquifer. Summer and fall data and the binary mixing model show aquifer inter‐flow mixing along solution fractures and confirms the distinctive groundwater geochemistry of the two aquifers. Lowering of static water levels over the summer (drawdown from 2 to 5.2 m) leads to more reducing groundwater conditions (lower Eh values) and slightly enriched δ18O and δD ratios during the fall [δ18O: −4.8 ± 0.1 to −5.4 ± 0.1‰ Vienna Standard Mean Oceanic Water (VSMOW), n = 9; δD: −25.4 ± 1 to −27.4 ± 1‰ VSMOW, n = 9] when compared with summer season samples (δ18O: −5.1 ± 0.1 to −5.7 ± 0.1‰ VSMOW, n = 11; δD: −25.0 ± 1 to −30.6 ± 1‰ VSMOW, n = 11). GIS analyses confirm the localized origin of recharge to the investigated aquifers. The combination of GIS, field parameters and geochemistry analyses can be successfully used to identify recharge sources, evaluate groundwater flow and transport pathways and to improve understanding of how groundwater withdrawals impact the sustainability and susceptibility to contamination of karst aquifers. Copyright © 2015 John Wiley & Sons, Ltd.
City Literacies in Second Languages
Authors: Mora Raúl Alberto 
Published: June 2015

AbstractThis article documents the current research efforts of a research team at a Colombian university to explore the new forms of literacies in second languages in the city. The different research projects from this research team aim to break the social imaginaries, often perpetuated in policies, that people in cities are not using English as a literacy resource and that all policies must, therefore, bring second languages to them. The findings from our studies portray a narrative that is far more complex than what policies may show, where people in the city are using English in their daily literacy practices in different ways that show creativity in the use of the language. The article introduces some of the challenges that the research team is facing to move into a more active approach to using their findings as options for policy and advocacy related to English literacies.
Nano forsterite biocomposites for medical applications: Mechanical properties and bioactivity
Authors: Furtos Gabriel , Naghiu Marieta‐Adriana , Declercq Heidi , Gorea Maria , Prejmerean Cristina , Pana Ovidiu , Tomoaia‐Cotisel Maria 
Published: June 2015

AbstractThe aim of the present study was to obtain and to investigate nano forsterite and nano forsterite biocomposites for biomedical application. New self‐curing forsterite biocomposites were obtained by mixing nano forsterite powder (5, 15, 30, 50, 70 wt %) with 2,2‐bis[4‐(2‐hydroxy‐3‐methacryloyloxypropoxy)‐phenyl]propane (bis‐GMA) and triethyleneglycol dimethacrylate (TEGDMA) monomers. The new nano forsterite biocomposites were investigated for mechanical properties: compressive strength (CS) (143–147.12 MPa), compressive modulus (CM) (1.67–2.75 GPa), diametral tensile strength (DTS) (27.33–31.55 MPa), flexural strength (FS) (59.47–83.20 MPa) and flexural modulus (FM) (2.05–8.60 GPa). Increases of CS, DTS, FS with increasing amount of forsterite were observed up to 50 wt %. The highest CM and FM values were registered for 70 wt % and a direct correlation between the forsterite volume fraction (%) was observed. SEM micrographs revealed the morphology of surface of fractured biocomposites after CS test. XPS indicated that these biocomposites promoted the hydroxyapatite formation on their surface immersed in simulated body fluid (SBF). AFM images showed that the growth of the hydroxyapatite layer occurs with a preferred orientation on the surface of forsterite biocomposites after immersion in SBF. Incorporation of nano forsterite in the polymer matrix (bis‐GMA/TEGDMA) did show osteoblast adhesion and proliferation was improved on nano forsterite biocomposites. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1290–1301, 2016.
Heat Shock Protein 90 Regulates Subcellular Localization of Smads in Mv1Lu Cells
Authors: Lee Jeeyong , An You Sun , Kim Mi‐Ra , Kim Ye‐Ah , Lee Jin Kyung , Hwang Chang Sun , Chung Eunkyung , Park In‐Chul , Yi Jae Youn 
Published: June 2015

ABSTRACTHeat shock protein 90 (HSP90) regulates the stability of various proteins and plays an essential role in cellular homeostasis. Many client proteins of HSP90 are involved in cell growth, survival, and migration; processes that are generally accepted as participants in tumorigenesis. HSP90 is also up‐regulated in certain tumors. Indeed, the inhibition of HSP90 is known to be effective in cancer treatment. Recently, studies showed that HSP90 regulates transforming growth factor β1 (TGF‐β1)‐induced transcription by increasing the stability of the TGF‐β receptor. TGF‐β signaling also has been implicated in cancer, suggesting the possibility that TGF‐β1 and HSP90 function cooperatively during the cancer cell progression. Here in this paper, we investigated the role of HSP90 in TGF‐β1‐stimulated Mv1Lu cells. Treatment of Mv1Lu cells with the HSP90 inhibitor, 17‐allylamino‐demethoxy‐geldanamycin (17AAG), or transfection with truncated HSP90 (ΔHSP90) significantly reduced TGF‐β1‐induced cell migration. Pretreatment with 17AAG or transfection with ΔHSP90 also reduced the levels of phosphorylated Smad2 and Smad3. In addition, the HSP90 inhibition interfered the nuclear localization of Smads induced by constitutively active Smad2 (S2EE) or Smad3 (S3EE). We also found that the HSP90 inhibition decreased the protein level of importin‐β1 which is known to regulate R‐Smad nuclear translocation. These data clearly demonstrate a novel function of HSP90; HSP90 modulates TGF‐β signaling by regulating Smads localization. Overall, our data could provide a detailed mechanism linking HSP90 and TGF‐β signaling. The extension of our understanding of HSP90 would offer a better strategy for treating cancer. J. Cell. Biochem. 117: 230–238, 2016. © 2015 Wiley Periodicals, Inc.
A proposal for scientific framework enabling specific population drug dosing recommendations
Authors: Jadhav Pravin R. , Cook Jack , Sinha Vikram , Zhao Ping , Rostami‐Hodjegan Amin , Sahasrabudhe Vaishali , Stockbridge Norman , Powell J. Robert 
Published: June 2015

AbstractOver the last 3 decades, there has been little change in the paradigm to derive dosing recommendations for specific populations (e.g., renal failure, elderly, or obese patients) despite better understanding of clearance pathways in these groups and availability of modeling and simulation tools. Dosing recommendations for specific populations are often incomplete or unavailable at the time of drug approval. Currently, there is no regulatory framework to incorporate model‐based dosing recommendations for specific populations. This paper proposes a scientific framework for using modeling and simulation to support specific population dosing recommendations. This framework creates a knowledgebase of drug and population attributes where model‐based approaches can be developed to inform dosing recommendations. The framework may benefit patients by having reliable dosing information at the time of drug approval. Patients with conditions where studies are difficult to perform would benefit from dosing based on state‐of‐the‐art knowledge. Industry and regulators would benefit from a scientific and efficient approach to improve specific population prediction. A research approach to determine specific population dose prediction is discussed along with challenges and risks. We hope to initiate a dialogue to explore the role of modeling based on data for drugs with similar clearance mechanisms to predict drug dosing.
Evaluating CCTs from a Gender Perspective: The Impact of Chile Solidario on Women's Employment Prospect
Authors: Scarlato Margherita , d'Agostino Giorgio , Capparucci Francesca 
Published: June 2015

AbstractThis paper examines the effects of the Chile Solidario programme on labour market outcomes from a gender perspective. Chile Solidario was implemented as the main anti‐poverty programme in Chile in 2002. The purpose of this conditional cash transfer is to provide poor families with auxiliary social services, including support for employment. We compare the gender impact of Chile Solidario using difference‐in‐differences and regression discontinuity design estimations based on data from the Chile Solidario Panel Survey. We find that the programme has a strong impact on labour market outcomes. However, the positive effects are particularly important for women subjects in the beneficiary families only after the achievement of the conditionalities imposed by the programme. This analysis suggests that cash transfers should be targeted more specifically to women's needs to contribute to their empowerment. Copyright © 2015 John Wiley & Sons, Ltd.
A systematic review of the effect of piston diameter in stapes surgery for otosclerosis on hearing results
Authors: Wegner Inge , Verhagen Jessica J. , Stegeman Inge , Vincent Robert , Grolman Wilko 
Published: June 2015

ObjectiveTo evaluate the effect of piston diameter in primary stapedotomy for otosclerosis patients measured by hearing outcome.Data SourcesPubMed, Embase, and the Cochrane Library.Review MethodsA systematic search was conducted. Studies reporting original data on the effect of piston diameter on pure‐tone audiometric results in patients undergoing primary stapedotomy for otosclerosis were included. Relevance and risk of bias of the selected articles were assessed. Studies with low relevance, high risk of bias, or both were excluded. Absolute risks and risk differences, means and mean differences, and 95% confidence intervals were extracted.ResultsTwelve studies with moderate to high relevance and moderate risk of bias were included for data extraction. Air‐bone gap closure to 10 dB or less was assessed in six studies, the majority of which did not show a statistically significant or clinically relevant difference between two pistons with a different diameter. More importantly, the differences that were found were not consistently in favor of smaller‐diameter pistons or larger‐diameter pistons. Mean postoperative air‐bone gap ranged from 3 dB in favor of a smaller‐diameter piston to 3 dB in favor of a larger‐diameter piston across four studies. Permanent sensorineural hearing loss was assessed in eight studies and occurred in only one study. In this study, no difference was found between a 0.4‐mm‐diameter piston and a 0.6‐mm‐diameter piston.ConclusionThere is not sufficient evidence to support the superiority of the use of a larger‐diameter piston compared to a smaller‐diameter piston for primary stapedotomy in otosclerosis patients.Level of EvidenceNA Laryngoscope, 126:182–190, 2016
Diagnostic accuracy of algorithms to identify hepatitis C status, AIDS status, alcohol consumption and illicit drug use among patients living with HIV in an administrative healthcare database
Authors: Durand Madeleine , Wang Yishu , Venne François , Lelorier Jacques , Tremblay Cécile L. , Abrahamowicz Michal 
Published: June 2015

AbstractPurposeThis study aims to develop and evaluate diagnostic algorithms for AIDS, hepatitis C status, alcohol abuse and illicit drug use in the administrative healthcare database of the Province of Quebec, Canada (Régie de l'assurance‐maladie du Québec (RAMQ)).MethodsWe selected HIV‐positive patients contributing to both the RAMQ database and a local clinical database, which was used as gold standard. We developed algorithms to identify the diagnoses of interest in RAMQ using data from hospital discharge summaries and medical and pharmaceutical claims databases. We estimated and compared sensitivity, specificity, positive predictive and negative predictive values and area under receiver operating curve for each algorithm.ResultsFour hundred twenty patients contributed to both databases. Prevalence of conditions of interest in the clinical database was as follows: AIDS 233 (55%), hepatitis C infection 105 (25%), alcohol abuse 106 (25%), illicit drug use 144 (34%) and intravenous drug use 107 (25%). Sensitivity to detect AIDS, hepatitis C, alcohol abuse, illicit drug use and intravenous drug use was 46% [95%CI: 39–53], 26% [18–35], 50% [37–57], 64% [55–72] and 70% [61–79], respectively. Specificity to detect these conditions was 91% [86–95], 97% [94–98], 92% [88–95], 95% [92–97] and 90% [87–93], respectively. Positive predictive values were 87% [80–92], 71% [54–85], 68% [56–78], 87% [79–93] and 72% [62–80], respectively. Area under receiver operating curve varied from 0.62 [0.57–0.65] for hepatitis C to 0.80 [0.76–0.85] for intravenous drug use.ConclusionsSensitivity was low to detect AIDS, alcohol abuse, illicit drug use and especially hepatitis C in RAMQ. Researchers must be aware of the potential for residual confounding and must consider additional methods to control for confounding. Copyright © 2015 John Wiley & Sons, Ltd.
A clinically based protein discovery strategy to identify potential biomarkers of response to anti‐TNF‐α treatment of psoriatic arthritis
Authors: Collins Emily S. , Butt Aisha Q. , Gibson David S. , Dunn Michael J. , Fearon Ursula , van Kuijk Arno W. , Gerlag Danielle M. , Pontifex Eliza , Veale Douglas J. , Tak Paul P. , FitzGerald Oliver , Pennington Stephen R. 
Published: June 2015

PurposePsoriatic arthritis (PsA) can be treated using biologic therapies targeting biomolecules such as tumor necrosis factor alpha, interleukins (IL)‐17 and IL‐23. Although 70% PsA patients respond well to therapy, 30% patients show no or limited clinical improvement. Biomarkers that predict response to therapy would help to avoid unnecessary use of expensive biologics in nonresponding patients and enable alternative treatments to be explored.Experimental designPatient synovial tissue samples from two clinical studies were analysed using difference in‐gel electrophoresis‐based proteomics to identify protein expression differences in response to anti‐TNF‐α treatment. Subsequent multiplexed MRM measurements were used to verify potential biomarkers.ResultsA total of 119 proteins were differentially expressed (p<0.05) in response to anti‐TNF‐α treatment and 25 proteins were differentially expressed (p<0.05) between “good responders” and “poor responders”. From these differentially expressed proteins, MRM assays were developed for four proteins to explore their potential as treatment predictive biomarkers.Conclusion and clinical relevanceGel‐based proteomics strategy has demonstrated differential protein expression in synovial tissue of PsA patients, in response to anti‐TNF‐α treatment. Development of multiplex MRM assays to these differentially expressed proteins has the potential to predict response to therapy and allow alternative, more effective treatments to be explored sooner.
Towards the algorithmic detection of archetypal structures in system dynamics
Authors: Schoenenberger Lukas , Schmid Alexander , Schwaninger Markus 
Published: June 2015

AbstractTraditionally, model analysis follows qualitative, heuristic, and trial‐and‐error‐driven approaches for testing dynamic hypotheses. Only recently have other methods like loop dominance analysis or control theory been proposed for this purpose. We advocate complementing established qualitative heuristics with a quantitative method for model analysis. To that end, we propose two algorithms to detect Wolstenholme's four generic problem archetypes within models. We tested these algorithms using the Maintenance and World Dynamics models. The approach presented in this paper is a first important step towards the identification of system archetypes in system dynamics and contributes to improving model analysis and diagnosis. Furthermore, our approach goes beyond diagnosis to eliciting solution archetypes, which foster the design and implementation of effective policies. Copyright © 2015 System Dynamics Society