bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical treatment of torticollis secondary to the presence of a congenital paracondylar process: illustrative case
Authors: Hey Grace , De Toledo Otavio , Gutierrez-Aguirre Salvador , Andreoli Steven , Patel Pushpak , Tamasi Alyssa , Hatem Asmaa , Aldana Philipp 
Published: July 2024

BACKGROUND
A paracondylar process is an abnormal bony exostosis arising from the skull base lateral to the occipital condyle and extending inferiorly toward the transverse process of the atlas. Paracondylar processes are typically identified incidentally and vary in size from a small protuberance to an elongated process.

OBSERVATIONS
The authors present the first pediatric case of torticollis secondary to a congenital paracondylar process successfully treated with resection of the paracondylar process and sternocleidomastoid release.

LESSONS
Cadaveric dissection, three-dimensional models, intraoperative imaging guidance, and multidisciplinary collaboration were paramount to a successful surgical outcome.
https://thejns.org/doi/10.3171/CASE2447
Development of Interactive STEAM Storybook to Improve Critical Thinking In 3rd Grade
Authors: Putri Aryanti Virli Dian , Airlanda Gamaliel Septian 
Published: July 2024

The research aims of this study are to develop the storybook STEAM-based learning (Science, Technology, Engineering, Arts, Mathematics) for mathematic learning to improve critical thinking skills in grade 3 students in Elementary Public School Bringin 02. This media was developed based on the STEAM approach, so the use of media through the syntax of analyzing, synthesizing, making conclusions, and organizing strategies and tactics. The excellence of this innovative work focuses on improving critical thinking skills and scientific literacy skills. The excellence of this innovative work focuses on improving critical thinking skills. The type of research is Research and Development (R&D) using the Borg and Gall development model. The STEAM Activity: The Three Sides of My Family learning media is deemed suitable by three experts, including a children's literature expert with a 91% rating in the excellent category, a media expert with a 96% rating in the excellent category, and a content expert with an 82% rating in the excellent category. The STEAM Activity book is considered practical by students at Public School Bringin 02, receiving a 100% rating in the excellent category. Using an independent samples t-test, the effectiveness is found to be significant at 0.013, indicating that the STEAM Activity book is effectively used to enhance students' critical thinking skills.
Pengembangan Media Lagu Mabar Dalam Mata Pelajaran Matematika Kelas 1 Sekolah Dasar Untuk Meningkatkan Kemampuan Problem Solving Peserta Didik
Authors: Wulandari Rasel , Setiawan Yohana 
Published: July 2024

Mengajar matematika tidak hanya dengan rumus tetapi juga bisa menggunakan lagu. Media pembelajaran sangat dibutuhkan sebagai media proses pembelajaran di sekolah, khususnya kelas 1 SD dalam materi mengenal bangun ruang. Dalam penelitian ini, metode yang digunakan adalah metode Research and Development (R&D) dari Sukmadinata tiga tahap, yaitu Studi Pendahuluan, Pengembangan Model, dan Uji Model. Kemudian dipadukan dengan model pengembangan ADDIE (Anylisis, Design, Development, Implementation dan Evaluation). Media yang dikembangkan berupa lagu anak-anak berjudul "MABAR". Media ini digunakan dalam materi pengantar untuk mengajar kelas 1 di SD Negeri 2 Ujungwatu. Lagu MABAR dinyatakan layak oleh ahli materi dan ahli media dengan presentase 97% dan 93% dengan kriteria sangat valid dan lagu MABAR dalam aspek pemecahan masalah telah dinilai oleh ahli materi dan media dengan rata-rata 97,5% dengan kriteria sangat valid. Lagu MABAR juga dinyatakan praktis oleh guru dan siswa yang memiliki rata-rata presentase 100% dengan kriteria sangat valid. Dengan menggunakan uji independent sample t-test memperoleh keefektifan dengan hasil signifikan 0,031 sehingga lagu MABAR efektif untuk digunakan.
Decision Making Career Mahasiswa Ditinjau dari Tingkat Pendidikan Orang Tua
Authors: Heldayaningsih Eva , Hardew Ayatullah Kutub 
Published: July 2024

Tingkat pendidikan merupakan faktor penting dalam decision making career mahasiswa karena interaksi anggota keluarga berdampak terhadap perkembangan aspirasi karier dan eksplorasi karier mahasiswa. Tingkat pendidikan orang tua dapat berpengaruh pada pemilihan karier mahasiswa karena orang tua dengan tingkat pendidikan tinggi cenderung memiliki harapan dan cita – cita yang tinggi terhadap mahasiswa. Tujuan dalam penelitian ini adalah untuk menguji secara empirik decision making career mahasiswa ditinjau dari tingkat pendidikan orang tua. Penelitian ini merupakan penelitian kuantitatif menggunakan pendekatan survey. Peneliti melakukan konstruksi alat ukur skala decision making career (24 aitem valid, α = 0,906) dan kuisioner tingkat pendidikan orang tua. Peneliti menggunakan uji komparatif analysis of varians satu arah (one-way anova) dan melakukan uji normalitas dan uji homogenitas sebelumnya. Teknik sampling yang digunakan dalam penelitian adalah purposive sampling dengan kriteria subjek penelitian merupakan mahasiswa/i anggota IMAPRES (Ikatan Mahasiswa Berprestasi) Kabupaten Wonogiri dengan populasi 818 mahasiswa. Pengambilan data dilakukan secara online dengan menggunakan website google formulir kepada 230 responden anggota IMAPRES. Hipotesis dalam penelitian ini dapat diterima dengan nilai signifikansi pendidikan Ayah sebesar 0,001 dan nilai signifikansi pendidikan Ibu sebesar 0,000 (p<0,05) yang berarti semakin kompleks decision making career mahasiswa sejalan dengan semakin tinggi tingkat pendidikan orang tua.
Subjective well-being of international students
Authors: Kim Soyean 
Published: July 2024

Students’ adjustment and well-being in a cross-cultural context have become important topics in international higher education studies. This study explored the psychological mechanism underlying the impact of perceived discrimination and perceived health status on the subjective well-being of international students. The responses of 358 international students were analyzed using the survey datasets. The results indicated that the perceived health status of international students had a significantly positive impact on their subjective well-being. Conversely, perceived discrimination had a negative impact on subjective well-being and community satisfaction. Notably, community satisfaction mediated the relationship between perceived discrimination and subjective well-being. Furthermore, the results revealed that the effect of community satisfaction on subjective well-being varied between the Asian and non-Asian students. These findings can assist higher education program providers in developing a community-oriented support system for students striving to adjust to cross-cultural environments.
A Pragmatic Study of Speech Acts in Fitzgerald’s ‘Crazy Sunday’ in terms of Searle’s Classification
Authors: Shehab Teeba Khalid 
Published: July 2024

By using Scott Fitzgerald's short tale "Crazy Sunday" and Searle's classification of speech acts, this study clarifies speech act theory. The philosopher Searle, classified speech acts into five categories; Declaratives, commissives, representatives, directives and expressives. Utterances of the above mentioned short story have been analyzed and classified into the categories proposed by Searle to see which category of speech acts is most frequently used in this short story which provide us with a new interpretation and impression about Fitzgerald’s ‘Crazy Sunday’ short story. Also, the style of the author has been overviewed in this paper.
In this study, utterances are evaluated and categorized in accordance with Searle's taxonomy of speech actions, with each category's frequency displayed underneath:-

Declaratives were used 27 times.
Representatives were used 69 times.
Commissives were used 9 times.
Directives were used 49 times.
Expressives were used 31 times.

In this respect, it was clear that the representative of speech acts were the most frequently used in this short story, so we get an impression that the description of stories and events is the most prevailing atmosphere in it.
La importancia de la química forense en la detección de sustancias ilícitas en muestras biológicas
Authors: Moncayo Hurtado Jazmín Rocío , Huacho Chalán Ángela Del Roció , Núñez León José Luis , Satán De Secaira Sandra Elizabeth 
Published: July 2024

Introducción: La detección de sustancias ilícitas en muestras biológicas es fundamental en el ámbito forense, con implicaciones significativas en investigaciones criminales, procesos judiciales. La química forense desempeña un papel crucial en este contexto, al brindar técnicas analíticas avanzadas para la identificación y cuantificación de estas sustancias. Objetivo: El presente estudio tiene como objetivo resaltar el papel crucial que desempeña la química forense en la identificación y cuantificación de drogas en muestras biológicas. Se informará al lector sobre las técnicas y herramientas analíticas que utiliza la química forense para detectar sustancias en muestras biológicas como sangre, orina, órganos y tejido. Metodología: Se utilizó el método de investigación cualitativa de revisión bibliografica que promovió la interacción entre los participantes del proceso, permitiendo el intercambio de experiencias. Se realizó la revisión y recolección de datos en la Biblioteca Científica Electrónicas entre ellos la búsqueda de artículos científicos en Google académico, Redalyc, PubMed y Elzevir se siguió un orden de lectura de los resúmenes y palabras clave. Resultados: En una búsqueda de 30 artículos y 1 libro. Se desarrolló el análisis de la importancia, las técnicas actualizadas para el análisis y las muestras biológicas a considerarse. Conclusiones: Finalmente podemos concluir el amplio alcance que tiene la química forense en todas las áreas de la investigación criminal. Área de estudio general: Criminalística y Ciencias forenses. Área de estudio específica: Técnicas Forenses. Tipo de estudio: Artículo original
Optimalisasi Edukasi Metode Brainstorming untuk Meningkatkan Self Care Management pada Pasien Hipertensi
Authors: Nurarifah Nurarifah , Sukmawati Sukmawati 
Published: July 2024

Hipertensi merupakan penyakit tidak menular dengan prevalensi yang terus meningkat setiap tahun. Permasalahan yang terjadi pada masyarakat yaitu kurangnya pemahaman tentang self care management sehingga menyebabkan tekanan darah yang tidak terkontrol dan beresiko mengakibatkan komplikasi yang berkelanjutan seperti stroke. Edukasi bertujuan untuk meningkatkan pengetahuan tentang manfaat dan hambatan dan upaya self care management dalam mengotrol tekanan darah. Metode pengabdian masyarakat yang digunakan yaitu pemeriksaan kesehatan, pemberian modul dan edukasi berbasis brainstoorming tentang self care management pada pasien hipertensi. Adapun hasil evalusi yang didapatkan adalah sebelum dilakukan edukasi dengan metode brainstorming peserta dengan tingkat pengetahuan baik tentang self care management hanya 13 peserta (37%) dan meningkat menjadi 31 peserta (89%). Peserta sangat antusias menyampaikan pendapat bahwa sangat penting melakukan pemeriksaan tekanan darah setiap bulan dan mengubah pola hidup dan pola perilaku. Diharapkan penyuluhan dilakukan secara terjadwal sehingga meningkatkan pengetahuan dan self care management pasien hipertensi.
Design and validation of a novel 3D-printed glenohumeral fusion prosthesis for the reconstruction of proximal humerus bone defects: a biomechanical study
Authors: Lin Jiaming , Song Guohui , Huang Anfei , Hu Jinxin , Tang Qinglian , Lu Jinchang , Huang Yufeng , Gong Ming , Zhu Xiaojun , Wang Jin 
Published: July 2024

BackgroundAll available methods for reconstruction after proximal humerus tumor resection have disadvantages, and the optimal reconstruction method remains uncertain. This study aimed to design a novel 3D-printed glenohumeral fusion prosthesis and verify its feasibility and safety using biomechanical methods.MethodsWe verified the feasibility and safety of the 3D-printed glenohumeral fusion prosthesis by finite element analysis and biomechanical experimentation. In the finite element analysis, three reconstruction methods were used, and displacement and von Mises stress were observed; on this basis, in the biomechanical experiment, models constructed with sawbones were classified into two groups. The force‒displacement curve of the 3D-printed prosthesis was evaluated.ResultsIn terms of displacement, the finite element analysis showed greater overall stability for the novel prosthesis than traditional glenohumeral joint arthrodesis. There was no obvious stress concentration in the internal part of the 3D-printed glenohumeral fusion prosthesis; the stable structure bore most of the stress, and the force was well distributed. Adding lateral plate fixation improved the stability and mechanical properties of the prosthesis. Furthermore, the biomechanical results showed that without lateral plate fixation, the total displacement of the prosthesis doubled; adding lateral plate fixation could reduce and disperse strain on the glenoid.ConclusionThe design of the 3D-printed glenohumeral fusion prosthesis was rational, and its stability and mechanical properties were better than those of traditional glenohumeral joint arthrodesis. Biomechanical verification demonstrated the feasibility and safety of this prosthesis, indicating its potential for proximal humerus bone defect reconstruction after tumor resection.
Role of circulating inflammatory protein in the development of diabetic renal complications: proteome-wide Mendelian randomization and colocalization analyses
Authors: Liu Wenli , Zhang Jiaqi , Zhang Duo , Zhang Lei 
Published: July 2024

BackgroundDiabetes ranks among the most widespread diseases globally, with the kidneys being particularly susceptible to its vascular complications. The identification of proteins for pathogenesis and novel drug targets remains imperative. This study aims to investigate roles of circulating inflammatory proteins in diabetic renal complications.MethodsData on the proteins were derived from a genome-wide protein quantitative trait locus (pQTL) study, while data on diabetic renal complications came from the FinnGen study. In this study, proteome-wide Mendelian randomization (MR) and colocalization analyses were used to assess the relationship between circulating inflammatory proteins and diabetic renal complications.ResultsMR approach indicated that elevated levels of interleukin 12B (IL-12B) (OR 1.691, 95%CI 1.179–2.427, P=4.34×10-3) and LIF interleukin 6 family cytokine (LIF) (OR 1.349, 95%CI 1.010–1.801, P=4.23×10-2) increased the risk of type 1 diabetes (T1D) with renal complications, while higher levels of fibroblast growth factor 19 (FGF19) (OR 1.202, 95%CI 1.009–1.432, P=3.93×10-2), fibroblast growth factor 23 (FGF23) (OR 1.379, 95%CI 1.035–1.837, P=2.82×10-2), C-C motif chemokine ligand 7 (CCL7) (OR 1.385, 95%CI 1.111–1.725, P=3.76×10-3), and TNF superfamily member 14 (TNFSF14) (OR 1.244, 95%CI 1.066–1.451, P=5.63×10-3) indicated potential risk factors for type 2 diabetes (T2D) with renal complications. Colocalization analysis supported these findings, revealing that most identified proteins, except for DNER, likely share causal variants with diabetic renal complications.ConclusionOur study established associations between specific circulating inflammatory proteins and the risk of diabetic renal complications, suggesting these proteins as targets for further investigation into the pathogenesis and potential therapeutic interventions for T1D and T2D with renal complications.
Causal linkage between angiotensin-converting enzyme 2 and risk of lung cancer: a bidirectional two-sample Mendelian randomization study
Authors: Chen Shubin , Ning Ruiling , Jiang Wei , Zhou Shaozhang , Yu Qitao , Gan Haijie 
Published: July 2024

BackgroundObservational studies suggest a connection between ACE2 (angiotensin-converting enzyme 2) and lung cancer. However, it's not apparent if confounding variables are interfering with the link. Therefore, we aimed to define the relationships between ACE2 and the risk of lung cancer.MethodsWith the aim of developing genetic tools, we selected SNPs substantially associated with ACE2 using a statistically significant criterion. The relevant SNPs were then taken from the lung cancer GWAS dataset for additional research. After that, we used two-sample Mendelian randomization (MR) to ascertain if ACE2 is causally linked to the risk of developing lung cancer. To investigate the causal links' directions, we also performed a reverse MR analysis.ResultsAccording to our findings, there is strong evidence that ACE2 is linked to a decreased chance of developing lung cancer (odds ratio: 0.94; 95% confidence interval: 0.90–0.98; P = 0.0016). The IVW method, the major MR analysis, was not impacted by heterogeneity in any of the analyses, according to Cochrane's Q test (PCochrane′sQ = 0.207). The MR-Egger intercept (Pintercept = 0.622) showed no indication of horizontal pleiotropy in any of the investigations. Outlier SNPs were not detected by the MR-PRESSO global test (Pglobaltest = 0.191). The leave-one-out analysis was performed, and the results showed a steady outcome. Nonsignificant causal estimates between lung cancer and ACE2 were produced by reverse MR analysis.ConclusionMR investigation revealed a significant causal link between ACE2 and the risk of getting lung cancer. These findings may have implications for public health measures aimed at reducing the incidence of lung cancer.
Exploring research hotspots and emerging trends in neuroimaging of vascular cognitive impairment: a bibliometric and visualized analysis
Authors: Xu Fangyuan , Dai Ziliang , Zhang Wendong , Ye Yu , Dai Fan , Hu Peijia , Cheng Hongliang 
Published: July 2024

BackgroundVascular cognitive impairment (VCI) manifests in memory impairment, mental slowness, executive dysfunction, behavioral changes, and visuospatial abnormalities, significantly compromising the quality of daily life for patients and causing inconvenience to caregivers. Neuroimaging serves as a crucial approach to evaluating the extent, location, and type of vascular lesions in patients suspected of VCI. Nevertheless, there is still a lack of comprehensive bibliometric analysis to discern the research status and emerging trends concerning VCI neuroimaging.ObjectiveThis study endeavors to explore the collaboration relationships of authors, countries, and institutions, as well as the research hotspots and frontiers of VCI neuroimaging by conducting a bibliometric analysis.MethodsWe performed a comprehensive retrieval within the Core Collection of Web of Science, spanning from 2000 to 2023. After screening the included literature, CiteSpace and VOSviewer were utilized for a visualized analysis aimed at identifying the most prolific author, institution, and journal, as well as extracting valuable information from the analysis of references.ResultsA total of 1,024 publications were included in this study, comprising 919 articles and 105 reviews. Through the analysis of keywords and references, the research hotspots involve the relationship between neuroimaging of cerebral small vessel disease (CSVD) and VCI, the diagnosis of VCI, and neuroimaging methods pertinent to VCI. Moreover, potential future research directions encompass CSVD, functional and structural connectivity, neuroimaging biomarkers, and lacunar stroke.ConclusionThe research in VCI neuroimaging is constantly developing, and we hope to provide insights and references for future studies by delving into the research hotspots and frontiers within this field.
Sex differences in the distribution and density of regulatory interneurons in the striatum
Authors: Van Zandt Meghan , Flanagan Deirdre , Pittenger Christopher 
Published: July 2024

IntroductionDysfunction of the cortico-basal circuitry – including its primary input nucleus, the striatum – contributes to neuropsychiatric disorders, such as autism and Tourette Syndrome (TS). These conditions show marked sex differences, occurring more often in males than in females. Regulatory interneurons, such as cholinergic interneurons (CINs) and parvalbumin-expressing GABAergic fast spiking interneurons (FSIs), are implicated in human neuropsychiatric disorders such as TS, and ablation of these interneurons produces relevant behavioral pathology in male mice, but not in females. Here we investigate sex differences in the density and distribution of striatal interneurons.MethodsWe use stereological quantification of CINs, FSIs, and somatostatin-expressing (SOM) GABAergic interneurons in the dorsal striatum (caudate-putamen) and the ventral striatum (nucleus accumbens) in male and female mice.ResultsMales have a higher density of CINs than females, especially in the dorsal striatum; females have equal distribution between dorsal and ventral striatum. FSIs showed similar distributions, with a greater dorsal-ventral density gradient in males than in females. SOM interneurons were denser in the ventral than in the dorsal striatum, with no sex differences.DiscussionThese sex differences in the density and distribution of FSIs and CINs may contribute to sex differences in basal ganglia function, particularly in the context of psychopathology.
Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program
Authors: Kumbhare Shreyas V. , Pedroso Inti , Joshi Bharat , Muthukumar Karthik M. , Saravanan Santosh K. , Irudayanathan Carmel , Kochhar Gursimran S. , Dulai Parambir S. , Sinha Ranjan , Almonacid Daniel E. 
Published: July 2024

IntroductionThe gut microbiome’s influence on weight management has gained significant interest for its potential to support better obesity therapeutics. Patient stratification leading to personalized nutritional intervention has shown benefits over one-size-fit-all diets. However, the efficacy and impact on the gut’s microbiome of personalizing weight loss diets based on individual factors remains under-investigated.MethodsThis study assessed the impact of Digbi Health’s personalized dietary and lifestyle program on weight loss and the gut microbiome end-points in 103 individuals. Participants’ weight loss patterns and gut microbiome profiles were analyzed from baseline to follow-up samples.ResultsSpecific microbial genera, functional pathways, and communities associated with BMI changes and the program’s effectiveness were identified. 80% of participants achieved weight loss. Analysis of the gut microbiome identified genera and functional pathways associated with a reduction in BMI, including Akkermansia, Christensenella, Oscillospiraceae, Alistipes, and Sutterella, short-chain fatty acid production, and degradation of simple sugars like arabinose, sucrose, and melibiose. Network analysis identified a microbiome community associated with BMI, which includes multiple taxa known for associations with BMI and obesity.DiscussionThe personalized dietary and lifestyle program positively impacted the gut microbiome and demonstrated significant associations between gut microbial changes and weight loss. These findings support the use of the gut microbiome as an endpoint in weight loss interventions, highlighting potential microbiome biomarkers for further research.