bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells
Authors: Gélineau Adélaïde , Marcelin Geneviève , Ouhachi Melissa , Dussaud Sébastien , Voland Lise , Manuel Raoul , Baba Ines , Rouault Christine , Yvan-Charvet Laurent , Clément Karine , Tussiwand Roxane , Huby Thierry , Gautier Emmanuel L. 
Published: June 2024

AbstractDiet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (HFD) in which lipids are enriched at the expense of dietary fibers. Such nutritional challenge alters glucose homeostasis as well as intestinal immunity. Here, we observed that short-term HFD induced dysbiosis, glucose intolerance and decreased intestinal RORγt+ CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells. However, supplementation of HFD-fed male mice with the fermentable dietary fiber fructooligosaccharides (FOS) was sufficient to maintain RORγt+ CD4 T cell subsets and microbial species known to induce them, alongside having a beneficial impact on glucose tolerance. FOS-mediated normalization of Th17 cells and amelioration of glucose handling required the cDC2 dendritic cell subset in HFD-fed animals, while IL-17 neutralization limited FOS impact on glucose tolerance. Overall, we uncover a pivotal role of cDC2 in the control of the immune and metabolic effects of FOS in the context of HFD feeding.
Level of heavy metals and environmental pollution index in Ahvaz, Southwest Iran
Authors: Mansouri Moghadam Sara , Payandeh Khoshnaz , Koushafar Azita , Goosheh Mohioddin , Mohammadi Rouzbahani Maryam 
Published: June 2024

AbstractThis study was designed to evaluate the concentration of heavy metals (HMs) in the north of Ahvaz, southwest Iran. The soil samples were collected from the agricultural farm and riverside in Karun, for the investigation of the environmental impacts of the selected HMs in the soil of the Weiss and Arab Assad regions. For soil sampling in a period, nine farms were selected from each region, and 10 samples were taken from each agricultural farm. Zoning was done using GIS. The highest of Contamination Factor, Enrichment factor and geo-accumulation index of HMs for Cd (7.84, 73.92 and 2.38), and the lowest value of this index for Cr (0.21, 1.98 and − 2.82), respectively. Furthermore of the farm soil showed that the most toxic effect is related to Cd. The HMs contamination indices of the soil samples showed that the studied HMs had contaminated the agricultural fields. Moreover, the zoning maps of the Co, Cu, Pb and Cr showed that they had not contaminated the soil of wheat fields, but Cd and Zn revealed high contamination levels. The zoning of Ni concentration distribution showed that this metal contamination came from both anthropogenic aspects and geological activities in the region. According to our findings, the EF illustrated high levels of pollution for Cd, Cu, Cr, Pb, Ni, Fe, Mn, Co, and Zn, which seems to be in accordance with the accumulation of agricultural fertilizers (phosphate and nitrate), industrial and human activities in the region.
Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells
Authors: Perea Paizal Julia , Au Sam H. , Bakal Chris 
Published: June 2024

AbstractDuring metastatic dissemination, circulating tumour cells (CTCs) enter capillary beds, where they experience mechanical constriction forces. The transient and persistent effects of these forces on CTCs behaviour remain poorly understood. Here, we developed a high-throughput microfluidic platform mimicking human capillaries to investigate the impact of mechanical constriction forces on malignant and normal breast cell lines. We observed that capillary constrictions induced nuclear envelope rupture in both cancer and normal cells, leading to transient changes in nuclear and cytoplasmic area. Constriction forces transiently activated cGAS/STING and pathways involved in inflammation (NF-κB, STAT and IRF3), especially in the non-malignant cell line. Furthermore, the non-malignant cell line experienced transcriptional changes, particularly downregulation of epithelial markers, while the metastatic cell lines showed minimal alterations. These findings suggest that mechanical constriction forces within capillaries may promote differential effects in malignant and normal cell lines.
Integration of molecular docking and molecular dynamics simulations with subtractive proteomics approach to identify the novel drug targets and their inhibitors in Streptococcus gallolyticus
Authors: Chao Peng , Zhang Xueqin , Zhang Lei , Yang Aiping , Wang Yong , Chen Xiaoyang 
Published: June 2024

AbstractStreptococcus gallolyticus (Sg) is a non-motile, gram-positive bacterium that causes infective endocarditis (inflammation of the heart lining). Because Sg has gained resistance to existing antibiotics and there is currently no drug available, developing effective anti-Sg drugs is critical. This study combined core proteomics with a subtractive proteomics technique to identify potential therapeutic targets for Sg. Several bioinformatics approaches were used to eliminate non-essential and human-specific homologous sequences from the bacterial proteome. Then, virulence, druggability, subcellular localization, and functional analyses were carried out to specify the participation of significant bacterial proteins in various cellular processes. The pathogen’s genome contained three druggable proteins, glucosamine-1phosphate N-acetyltransferase (GlmU), RNA polymerase sigma factor (RpoD), and pantetheine-phosphate adenylyltransferase (PPAT) which could serve as effective targets for developing novel drugs. 3D structures of target protein were modeled through Swiss Model. A natural product library containing 10,000 molecules from the LOTUS database was docked against therapeutic target proteins. Following an evaluation of the docking results using the glide gscore, the top 10 compounds docked against each protein receptor were chosen. LTS001632, LTS0243441, and LTS0236112 were the compounds that exhibited the highest binding affinities against GlmU, PPAT, and RpoD, respectively, among the compounds that were chosen. To augment the docking data, molecular dynamics simulations and MM-GBSA binding free energy were also utilized. More in-vitro research is necessary to transform these possible inhibitors into therapeutic drugs, though computer validations were employed in this study. This combination of computational techniques paves the way for targeted antibiotic development, which addresses the critical need for new therapeutic strategies against S. gallolyticus infections.
Study on the path of high-quality development of the construction industry and its applicability
Authors: Wang Dong , Cheng Xiaoduo 
Published: June 2024

AbstractExploring the influencing factors and enhancement paths of high-quality development of the construction industry is crucial for promoting sustainable development of the construction industry. Based on the concepts of “five development”, this paper takes the construction industry data of 29 provinces (autonomous regions and municipalities) in China as a sample, utilizes comprehensively the combination method of NCA and fsQCA to build a high-quality development driving model of the construction industry, and explores the coupling effect of factors, like the level of scientific and technological innovation, structural degree, precast building model, external market vitality, resources, and environment, on the development of the industry, revealing the path of high-quality development of the construction industry and analyze its applicability. These findings demonstrate that: (1) The level of scientific and technological innovation, the degree of structure, and the vitality of the external market are the core conditions, and a single factor does not constitute the necessary conditions for the high-quality development of the construction industry; (2) There are three paths for the high-quality development of the construction industry, among which the number of representative cases of linkage development led by openness innovation coordination is the largest, and has strong applicability; (3) There are two non-high-quality development paths in the construction industry, and there is a non-simple opposition relationship with the three high-quality development paths in the construction industry.
In vitro effect of visfatin on endocrine functions of the porcine corpus luteum
Authors: Mlyczyńska Ewa , Rytelewska Edyta , Zaobidna Ewa , Respekta-Długosz Natalia , Kopij Grzegorz , Dobrzyń Kamil , Kieżun Marta , Smolińska Nina , Kamiński Tadeusz , Rak Agnieszka 
Published: June 2024

AbstractPreviously, we demonstrated the expression of visfatin in porcine reproductive tissues and its effect on pituitary endocrinology. The objective of this study was to examine the visfatin effect on the secretion of steroid (P4, E2) and prostaglandin (PGE2, PGF2α), the mRNA and protein abundance of steroidogenic markers (STAR, CYP11A1, HSD3B, CYP19A1), prostaglandin receptors (PTGER2, PTGFR), insulin receptor (INSR), and activity of kinases (MAPK/ERK1/2, AKT, AMPK) in the porcine corpus luteum. We noted that the visfatin effect strongly depends on the phase of the estrous cycle: on days 2–3 and 14–16 it reduced P4, while on days 10–12 it stimulated P4. Visfatin increased secretion of E2 on days 2–3, PGE2 on days 2–3 and 10–12, reduced PGF2α release on days 14–16, as well as stimulated the expression of steroidogenic markers on days 10–12 of the estrous cycle. Moreover, visfatin elevated PTGER mRNA expression and decreased its protein level, while we noted the opposite changes for PTGFR. Additionally, visfatin activated ERK1/2, AKT, and AMPK, while reduced INSR phosphorylation. Interestingly, after inhibition of INSR and signalling pathways visfatin action was abolished. These findings suggest a regulatory role of visfatin in the porcine corpus luteum.
Differences between subjective and disability health expectancies across ages in older adults
Authors: Gbessemehlan Antoine , Cambois Emmanuelle , Brouard Nicolas , Letenneur Luc , Amieva Hélène , Pérès Karine 
Published: June 2024

AbstractHealth expectancies (HEs) have become a key indicator for monitoring healthy aging. So far, they have mainly been calculated based on functional rather than subjective health measures. Yet, by integrating several dimensions (medical, social, and cultural), subjective health is also an important measure of an older person’s health status. In this study, we first estimated HEs using self-rated health (SRH), by age and sex. Second, we compared these results to those obtained when using a disability measure. We used pooled data from three prospective population-based cohorts including adults aged 65 years and over, living in Southwestern France (N = 4468). SRH was assessed using a single question and disability was measured using the Lawton scale. Healthy/Unhealthy Life Expectancies (HLE/UHLE) and Disability/Disability-Free Life Expectancies (DLE/DFLE) were estimated using the Interpolated Markov Chain program (IMaCh), separately in men and women. Women lived longer than men, with similar HLE but longer UHLE at all ages. The proportion of HLE in total LE decreased with age for both sexes and for women, it became smaller than the proportion of UHLE from age 73 onward. In both sexes, while the DLE was shorter than the UHLE in the youngest, a reversal was observed with advancing age. This change occurred earlier in women. Our study supports that SRH and disability showed different aging patterns, with sex and age differences. From a public health perspective, SRH and disability indicators appeared not interchangeable as they uncovered complementary but different information on the needs of aging people.
Radiological and functional outcomes of Reverdin Isham osteotomy in moderate Hallux Valgus: a systematic review and meta-analysis
Authors: Sanchís-Soria Victoria , Nieto-González Elena , Nieto-García Eduardo , Fernández-Ehrling Nadia , Ferrer-Torregrosa Javier , Lorca-Gutiérrez Rubén 
Published: June 2024

AbstractThis systematic review and meta-analysis addresses the effects of minimally invasive surgical techniques, specifically the Reverdin Isham osteotomy, on functional and radiological outcomes in patients with moderate Hallux Valgus, a common foot deformity. The review included randomized and non-randomized controlled trials, as well as case reports, assessing the osteotomy in adults with moderate to severe Hallux Valgus. Searches were conducted in electronic databases such as MEDLINE and Web of Science up until July 2023, and the Joanna Briggs Institute’s critical appraisal tool was used to assess the risk of bias. Meta-analytical analyses employed a random-effects model with small-sample correction, presenting results as standardized mean differences and mean differences with 95% confidence intervals. Seven studies involving 554 patients and 643 operated feet were included, showing significant improvements in AOFAS scores (an average improvement of 36 points from 28.61 to 45.16) and reductions in radiological angles such as the distal metatarsal angle and hallux valgus angle post-surgery (IMA improved by − 3.07° from − 4.68 to − 1.46, DMAA by − 6.12° from − 9.52 to − 2.71, and HVangle by − 15.27° from − 17.98 to − 12.57). Despite these positive outcomes, most studies exhibited risks of bias and other methodological limitations, impacting the generalizability of the results. Overall, the findings highlight the efficacy of the Reverdin Isham osteotomy in improving both functional and radiological parameters in patients with moderate Hallux Valgus, although further research is warranted to solidify these results. No specific funding was received for this study, and the protocol was registered on PROSPERO with the number CRD-42023445886.
Synthesis of 3,4-dihydropyrimidines and octahydroquinazolinones by SBA-15 supported schiff-base iron (III) complex as durable and reusable catalyst under ultrasound irradiation
Authors: Balali Zeynab , Safaei-Ghomi Javad , Mashhadi Elahe 
Published: June 2024

AbstractBiginelli-type heterocyclic compounds are particularly important due to their several chemical reactivities and various range of pharmacological activity. Therefore Biginelli reaction has witnessed several modification and numerous investigations are continuing in this field to develop more effective and efficient methodologies. In this research, Iron (III) schiff base immobilized SBA-15 has been prepared as a valuable, efficient, and recoverable catalyst for the Biginelli reaction. The morphology of the prepared catalyst was identified by spectroscopic characterization techniques and structural microscopic analysis including Fourier transform infrared (FT-IR) patterns, X-ray diffraction (XRD) by powder crystal method, Energy-dispersive X-ray spectroscopy (EDS) study, Thermogravimetric-Differential thermal analysis (TGA-DTA), Transmission electron microscopy (TEM) and Field emission scanning electron microscopy (FE-SEM) images. Biginelli compounds containing 3,4-dihydropyrimidines and octahydroquinazolinones were conveniently synthesized by this catalyzed protocol from the cycloaddition of aromatic aldehydes with the 1,3-dicarbonyl substrates and urea via ultrasonic waves. The several advantages of the presented approach are high yields and easy isolation of products, shorter reaction times, and milder conditions, structural stability and reusable catalyst. The combination of heterogeneous catalyst and ultrasonic radiation can make catalytic reactions more efficient than traditional ways attractive for academic researchers and application scholars in the industry.
Physical and thermomechanical characterization of unidirectional Helicteres isora fiber-reinforced polylactic acid bio-composites
Authors: Acharya Prashantha , Pai Dayananda , Padmaraj N. H. , Mahesha G. T. 
Published: June 2024

AbstractIdentifying novel cellulose fiber bio-composites has become a vital initiative in the exploration of sustainable materials due to increased global concern for the environment. This growing focus on eco-friendly materials has gathered significant attention in recent years. The current investigation deals with one such material, Helicteres isora reinforced Polylactic acid composites. Surface chemical treatment of fiber is one of the most effective methods to modify the hydrophilic fiber to increase its compatibility with the polymer matrix. Sodium hydroxide was used as a pre-treatment chemical to remove any impurities from the fiber surface. Pre-treated fibers were treated with Methacryl silane and Potassium permanganate solution to chemically modify the fiber surface. Density, void content and water absorption behavior of the composites were analyzed as per the standard procedure. Tensile and flexural tests were conducted to evaluate the mechanical strength, modulus, and flexibility of the unidirectional composites. Thermogravimetric and differential thermal analyses were performed to investigate the thermal stability, melting behavior and degradation profiles of prepared composites. A study of failure mechanisms and morphology of the fractured surface through photographs and SEM images revealed fiber splitting and delamination as the dominant reasons behind the failure of composites under tensile loading. Silane-treated Helicteres isora fiber-reinforced Polylactic acid composite exhibited lower water absorption and higher tensile strength than its counterparts. Untreated fiber composite showed maximum flexural strength among the tested composites. By collectively evaluating the results of the tests and properties of the composites, silane-treated fiber-reinforced Polylactic acid composites stands out as the most favorable choice.
Enhanced coalbed methane well production prediction framework utilizing the CNN-BL-MHA approach
Authors: Li Xianxian , Li Xijian , Xie Honggao , Feng Cong , Cai Junjie , He Yuhuan 
Published: June 2024

AbstractAs the mechanization of the CBM extraction process advances and geological conditions continuously evolve, the production data from CBM wells is deviating increasingly from linearity, thereby presenting a significant challenge in accurately predicting future gas production from these wells. When it comes to predicting the production of CBM, a single deep-learning model can face several drawbacks such as overfitting, gradient explosion, and gradient disappearance. These issues can ultimately result in insufficient prediction accuracy, making it important to carefully consider the limitations of any given model. It’s impressive to see how advanced technology can enhance the prediction accuracy of CBM. In this paper, the use of a CNN model to extract features from CBM well data and combine it with Bi-LSTM and a Multi-Head Attention mechanism to construct a production prediction model for CBM wells—the CNN-BL-MHA model—is fascinating. It is even more exciting that predictions of gas production for experimental wells can be conducted using production data from Wells W1 and W2 as the model’s database. We compared and analyzed the prediction results obtained from the CNN-BL-MHA model we constructed with those from single models like ARIMA, LSTM, MLP, and GRU. The results show that the CNN-BL-MHA model proposed in the study has shown promising results in improving the accuracy of gas production prediction for CBM wells. It’s also impressive that this model demonstrated super stability, which is essential for reliable predictions. Compared to the single deep learning model used in this study, its prediction accuracy can be improved up to 35%, and the prediction results match the actual yield data with lower error.
MOI is a comprehensive database collecting processed multi-omics data associated with viral infection
Authors: Guo Xuefei , Zhao Yang , You Fuping 
Published: June 2024

AbstractViral infections pose significant public health challenges, exemplified by the global impact of COVID-19 caused by SARS-CoV-2. Understanding the intricate molecular mechanisms governing virus-host interactions is pivotal for effective intervention strategies. Despite the burgeoning multi-omics data on viral infections, a centralized database elucidating host responses to viruses remains lacking. In response, we have developed a comprehensive database named ‘MOI’ (available at http://www.fynn-guo.cn/), specifically designed to aggregate processed Multi-Omics data related to viral Infections. This meticulously curated database serves as a valuable resource for conducting detailed investigations into virus-host interactions. Leveraging high-throughput sequencing data and metadata from PubMed and Gene Expression Omnibus (GEO), MOI comprises over 3200 viral-infected samples, encompassing human and murine infections. Standardized processing pipelines ensure data integrity, including bulk RNA sequencing (RNA-seq), single-cell RNA-seq (scRNA-seq), Chromatin Immunoprecipitation sequencing (ChIP-seq), and Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq). MOI offers user-friendly interfaces presenting comprehensive cell marker tables, gene expression data, and epigenetic landscape charts. Analytical tools for DNA sequence conversion, FPKM calculation, differential gene expression, and Gene Ontology (GO)/ Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment enhance data interpretation. Additionally, MOI provides 16 visualization plots for intuitive data exploration. In summary, MOI serves as a valuable repository for researchers investigating virus-host interactions. By centralizing and facilitating access to multi-omics data, MOI aims to advance our understanding of viral pathogenesis and expedite the development of therapeutic interventions.
Reconfigurable spintronic logic gate utilizing precessional magnetization switching
Authors: Liu Ting , Li Xiaoguang , An Hongyu , Chen Shi , Zhao Yuelei , Yang Sheng , Xu Xiaohong , Zhou Cangtao , Zhang Hua , Zhou Yan 
Published: June 2024

AbstractIn traditional von Neumann computing architecture, the efficiency of the system is often hindered by the data transmission bottleneck between the processor and memory. A prevalent approach to mitigate this limitation is the use of non-volatile memory for in-memory computing, with spin–orbit torque (SOT) magnetic random-access memory (MRAM) being a leading area of research. In this study, we numerically demonstrate that a precise combination of damping-like and field-like spin–orbit torques can facilitate precessional magnetization switching. This mechanism enables the binary memristivity of magnetic tunnel junctions (MTJs) through the modulation of the amplitude and width of input current pulses. Building on this foundation, we have developed a scheme for a reconfigurable spintronic logic gate capable of directly implementing Boolean functions such as AND, OR, and XOR. This work is anticipated to leverage the sub-nanosecond dynamics of SOT-MRAM cells, potentially catalyzing further experimental developments in spintronic devices for in-memory computing.
In vitro fermentation reveals an interplay relationship between oat β-glucan and human gut Bacteroides and their potential role in regulating gut cytokines
Authors: Bai Junying , Wang Jing , Fan Mingcong , Li Yan , Huang Linhua , Wang Li 
Published: June 2024

Dietary oat β-glucan is metabolized human gut Bacteroides via glycoside hydrolases and further affects gut health.