bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serosal overturning assisted endoscopic full‐thickness mucosal resection of extraneous giant mass at the esophagogastric junction
Authors: Qin Shumin , Lin Xiaofeng , Wen Shuting , Liu Tianwen 
Published: August 2024

Key Clinical MessageSerosal overturning assisted endoscopic full‐thickness mucosal resection was performed on the extraneous giant masses at the esophagogastric junction without complications.AbstractIt is difficult to perform endoscopic resection of masses at the gastroesophageal junction (GEJ). In particular, the extraneous giant masses surrounding the extraneous giant masses is infrequent. As one of the technologies of endoscopic resection, endoscopic full‐thickness resection (EFTR) is generally applicable to the submucosal tumor of stomach, duodenum and colorectal that originate from the musculus propria and protrude to subserous or partial growth outside the luminal layer. Successful endoscopic repair of perforation is crucial in avoiding the need for surgical repair and preventing postoperative peritonitis, making it a key aspect of EFTR treatment. We report a 56‐year‐old woman who was admitted to our department complaining of 5‐year history of masses of esophagogastric junction and 2‐month history of feeling of gastric distension. Gastroscopy showed a 4 cm submucosal mass near the fundus of the stomach from the cardia. Computed tomography scan revealed submucosal lesions in esophagogastric junction, which was exogenous. We successfully performed Serosal overturning assisted endoscopic full‐thickness mucosal resection on the extraneous giant masses at the esophagogastric junction without complications. The clinical symptoms were significantly improved within postoperative 1 month. There was no recurrence 8 months after the operation. Serosal overturning assisted EFTR is possibly an effective and minimally invasive method of extraneous giant masses at the esophagogastric junction.
A case of type 2 diabetes mellitus with limb‐shaking TIA
Authors: Yoshimichi Go 
Published: August 2024

Key Clinical MessageLimb‐shaking transient ischemic attack (TIA) is a rare manifestation of carotid‐occlusive damage. This case report highlights the importance of accurate diagnosis and treatment of bilateral ballism as limb‐shaking TIA. Superficial cephalic artery and mid‐large artery anastomosis was performed after the initial acute treatment, and involuntary limb shaking disappeared.
Cryoballoon ablation using the sheath‐in‐sheath technique in a patient with a tortuous common iliac vein
Authors: Kasai Yuhei , Kitai Takayuki , Morita Junji , Iitsuka Kizuku , Haraguchi Takuya , Tsujimoto Masanaga , Okada Takuya , Munakata Yumetsugu , Kasai Jungo , Fujita Tsutomu 
Published: August 2024

Key Clinical MessageThe sheath‐in‐sheath technique, utilizing a 15Fr cryoballoon delivery sheath inserted into a 25 cm 16Fr sheath, effectively navigates tortuous iliac veins during cryoballoon ablation for atrial fibrillation, ensuring safe delivery and maintaining essential device performance without complications.
Whole‐exome sequencing and copy number alterations analysis in a case of expansive florid cemento‐osseous dysplasia
Authors: Gomes Carolina Cavaliéri , Bastos Victor Coutinho , El Mouatani Ahmed , Duarte‐Andrade Filipe Fideles , Jabado Nada , de Castro Wagner Henriques , Gomez Ricardo Santiago 
Published: August 2024

Key Clinical MessageWhole‐exome sequencing (WES) analysis of an expansive case florid cemento‐osseus dysplasia were reported for the first time. Also, the new potential candidate genes were reported to expand our knowledge about their molecular pathogenesis.AbstractWe report a case of expansive florid cemento‐osseus dysplasia in a 32‐year‐old female patient who presented an expansive tumoral lesion in the anterior mandible. As florid cemento‐osseus dysplasia have only been molecularly investigated using targeted‐sequencing, fragments of the lesion were collected and subjected to molecular investigation using WES to assess somatic mutations as well as copy number alterations. No gains and losses of chromosomal arms or segments longer than 1 Mb were detected. Our findings revealed a pathogenic stopgain variant at the KIF5C gene, a stoploss variant at MAPK10, and missense SNV at COL6A2 at DCDC1, suggesting potential candidate genes associated with florid cemento‐osseus dysplasia.
A rare case of cicatricial pemphigoid confined to the scalp with associated photodamage
Authors: Niknezhad Nasim , Golchin Nushin , Hasanzadeh Saba , Ghalamkarpour Fariba 
Published: August 2024

Key Clinical MessageWe present a case of Brunsting‐Perry characterized as an erythematous erosive plaque on photodamaged scalp skin, flaring after a recent prolonged sun exposure. Subsequent progression with blister formation led to the correct diagnosis, highlighting the need to consider cicatricial pemphigoid in eroded lesions without blisters, particularly on photodamaged skin.
Adjusted Pareto Scaling for Multivariate Calibration Models
Authors: Varmuza Kurt , Filzmoser Peter 
Published: August 2024

ABSTRACTThe performance of multivariate calibration models ŷ = f(x) for the prediction of a numerical property y from a set of x‐variables depends on the type of scaling of the x‐variables. Common scaling methods are autoscaling (dividing the centered x by its standard deviation s) and Pareto scaling (dividing the centered x by sP with P = 0.5). The adjusted Pareto scaling presented here varies the exponent P between 0 (no scaling) and 1 (autoscaling) with the aim of obtaining an optimum prediction performance for ŷ. Related scaling methods based on the variable spread are range scaling and vast scaling; while level scaling is based on the location (central value) of the variable. These scaling methods and robust versions are compared for models created by partial least‐squares (PLS) regression. The applied strategy repeated double cross validation (rdCV) evaluates the model performance for test set objects and considers its variability. Results with three data sets from chemistry show: (a) the efficacy of the different scaling methods depends on the data structure; (b) optimization of the Pareto exponent P is recommended; (c) range scaling or vast scaling may be better than adjusted Pareto scaling; (d) in general a heuristic search for the best scaling method is advisable. Overall, the consideration of different variants of scaling allow for a flexible adjustment of the variable contributions to the calibration model.
What are the methodological characteristics of evidence and gap maps? A systematic review and evidence and gap map
Authors: Fredlund Mary , Rogers Morwenna , Orr Noreen , Kneale Dylan , Allen Kate , Thompson Coon Jo 
Published: August 2024

AbstractIntroductionClarity on the characteristics of methods used to produce evidence and gap maps (EGMs) will highlight areas where method development is needed to ensure these increasingly produced tools are made following best practice to assure their quality and utility. This paper aims to describe the range, nature and variability of key methodological characteristics of studies publishing EGMs.MethodsWe followed a protocol, written a‐prior and informed by PRISMA and MECCIR guidelines for undertaking systematic reviews. We searched nine data bases, from 2010, for studies across any discipline that included details of their methods used to produce an EGM. Search results were screened by two reviewers independently and the subsequent data was extracted and managed according to predefined criteria. We mapped these together with the year of publication and the area of research as the two primary dimensions. We followed established methods for mapping the evidence, including the process of developing the map framework and the filters for our interactive map. We sought input and involvement from stakeholders during this process.ResultsWe found 145 studies from nine distinct research areas, with health research accounting for 67%. There were 11 map designs found, of these bubble plots were the most common design, before 2019, since then it has been a matrix map design. Stakeholders were involved in 47.7% of studies, 48.35% of studies stated finding gaps was an aim of their work, 42% reported publishing or registering a protocol and only 9.39% of studies mentioned a plan to update their evidence maps/EGMs.Discussion/ConclusionKey areas of methodological development relate to: the involvement of stakeholders, the conceptualization of gaps and the practices for updating maps. The issues of ambiguity in terminology, the flexibility of visualizations of the data and the lack of reporting detail were other aspects that needs further consideration in studies producing an EGM.
Adaptation of the BaAl4 Type to Small Cations: The Case of NaGa4
Authors: Yu Chia‐Chi , Prots Yurii , Koželj Primož , Wagner Frank R. , Baitinger Michael , Grin Yuri 
Published: August 2024

AbstractSingle‐phase NaGa4 samples were prepared by annealing stoichiometric element mixtures at 200 °C, 300 °C, and 450 °C in closed tantalum ampoules. No compositional homogeneity range was detected. While single crystals annealed at 200 °C feature a fully ordered crystal structure, a crystal annealed at 300 °C reveals a defect with mutual exchange of Na atoms and Ga2 dumbbells. The structure motif caused by the violation of translational symmetry resembles the CeMg2Si2 type of structure. The NaGa4 structure constitutes a branch of the BaAl4 type distinguished by a notably high c/a ratio (space group I4/mmm; a=4.2261(1) Å, c=11.2633(6) Å, c/a=2.67). This distortion enables the adaption of the BaAl4‐type to small cations, when the further shortening of the apical–apical distance d(Ga–Ga) is not possible any more. Therefore, NaGa4 offers an adaption alternative to the monoclinic distortion observed in CaGa4 and YbGa4. Conductivity measurements validate the metallic behavior anticipated by NMR measurements in earlier studies.
Emerging strategies for the improvement of modifications in aqueous rechargeable zinc–iodine batteries: Cathode, anode, separator, and electrolyte
Authors: Zhao Yuwei , Chen Xinyu , Guo Weina , Zha Chenyang 
Published: August 2024

AbstractAqueous rechargeable zinc–iodine batteries have gained traction as a promising solution due to their suitable theoretical energy density, cost‐effectiveness, eco‐friendliness, and safety features. However, challenges such as the polyiodide shuttle effect, low iodine cathode conductivity, zinc anode dendritic growth, and the requirement for efficient separators and electrolytes hinder their commercial prospects. Hence, this review highlights recent progress in refining the core optimization strategies of zinc–iodine batteries, focusing on enhancements to the cathode, anode, separator, and electrolyte. Cathode improvements involve the addition of inorganic, organic, and hybrid materials to counteract the shuttle effect and boost redox kinetics, where these functional materials also are applied in anode modifications to curb dendritic growth and enhance cycling stability. Meanwhile, cell separator design approaches that effectively block polyiodide shuttle while promoting uniform zinc deposition are also discussed, while electrolyte innovations target zinc corrosion and polyiodide dissolution. Ultimately, the review aims to map out a strategy for developing zinc–iodine batteries that are efficient, safe, and economical, aligning with the demands of contemporary energy storage.
Response of Foldable Protein Conformations to Non‐Physiological Perturbations: Interplay of Thermal Factors and Confinement
Authors: Layek Sarbajit , Sengupta Neelanjana 
Published: August 2024

AbstractTechnological advances frequently interface biomolecules with nanomaterials at non‐physiological conditions, necessitating response characterization of key processes. Similar encounters are expected in cellular contexts. We report in silico investigations of the response of diverse protein conformational states to lowering of temperature and imposition of spatial constraints. Conformational states are represented by folded form of the Albumin binding domain (ABD) protein, its compact denatured form, and structurally disordered nascent folding elements. Data from extensive simulations are evaluated to elicit structural, thermodynamic and dynamic responses of the states and their associated environment. Analyses reveal alterations to folding propensity with reduced thermal energy and confinement, with signatures of trend reversal in highly disordered states. Across temperatures, confinement has restrictive effects on volume and energetic fluctuations, leading to narrowing of differences in isothermal compressibility (κ) and heat capacities (Cp). While excess (over ideal gas) entropy of the hydration layer marks dependence on the conformational state at bulk, confinement triggers erasure of differences. These observations are largely consistent with timescales of protein‐water hydrogen bonding dynamics. The results implicate multi‐factorial associations within a simple bio‐nano complex. We expect the current study to motivate investigations of more biologically relevant interfaces towards mechanistic understanding and potential applications.
Continuous Flow Synthesis of Hexyl Laurate Using Immobilized Thermomyces Lanuginosus Lipase from Residual Babassu Mesocarp
Authors: de S. Lira Regiane K. , do Nascimento Marcelo A. , Lima Marcelo T. , Georgii Ana Débora N. P. , Leão Raquel A. C. , de Souza Rodrigo O. M. A. , Wojcieszak Robert , Leite Selma G. F. , Ivaldo Itabaiana Jr 
Published: August 2024

AbstractBrazil has one of the greatest biodiversities on the planet, where various crops play a strategic role in the country's economy. Among the highly appreciated biomasses is babassu, whose oil extraction generates residual babassu mesocarp (BM), which still needs new strategies for valorization. This work aimed to use BM as a support for the immobilization of Thermomyces lanuginosus lipase (TLL) in an 8.83 mL packed‐bed reactor, followed by its application as a biocatalyst for the synthesis of hexyl laurate in an integrated process. Initially, the percolation of a solution containing 5 mg of TLL at 25 °C and flows ranging from 1.767 to 0.074 mL min−1 was investigated, where at the lowest flow rate tested (residence time of 2 h), it was possible to obtain an immobilized derivative with hydrolytic activity of 504.7 U g−1 and 31.7 % of recovered activity. Subsequent studies of treatment with n‐hexane, as well as the effect of temperature on the immobilization process, were able to improve the activities of the final biocatalyst BM‐TLLF, achieving a final hydrolysis activity of 7023 U g−1 and esterification activity of 430 U ⋅ g−1 against 142 U g−1 and 113.5 U g−1 respectively presented by the commercial TLIM biocatalyst. Desorption studies showed that the TL IM has 18 mg of protein per gram of support, compared to 4.92 mg presented by BM‐TLL. Both biocatalysts were applied to synthesize hexyl laurate, achieving 98 % conversion at 40 °C within 2 h. Notably, BM‐TLLF displayed exceptional recyclability, maintaining catalytic efficiency over 12 cycles. This reflects a productivity of 180 mg of product ⋅ h−1 U−1 of the enzyme, surpassing 46 mg h−1 U−1 obtained for TLIM. These results demonstrate the efficacy of continuous flow technology in creating a competitive and integrated process offering an exciting alternative for the valorization of residual lignocellulosic biomass.
Evaluating the Effects of Cigarette Smoking and Heated Tobacco Products on Hard Dental Tissues: A Comparative Histological and Colorimetric Analysis
Authors: Al Ankily Mahmoud , Makkeyah Fatma , Bakr Mahmoud M. , Shamel Mohamed 
Published: August 2024

ABSTRACTObjectivesThis study aimed to evaluate and compare the impact of cigarette smoking (CS) and heated tobacco (HT) on the alteration of color and ultrastructural characteristics of human enamel and cementum.BackgroundAccording to tobacco companies, a less harmful substitute for CS is HT products. Nevertheless, comprehensive research on the effects of HT on tooth structures has been lacking. This study aimed to evaluate and compare the impact of CS and HT on the alteration of color and ultrastructural characteristics of human enamel and cementum.Materials and MethodsThirty intact and noncarious human maxillary premolars extracted for orthodontic treatment purposes, previously disinfected, were used in the study. The specimens were randomly separated into six groups (n = 10), as follows: Group 1: enamel without smoking exposure; Group 2: enamel exposed to CS; Group 3: enamel exposed to HT; Group 4: cementum without smoking exposure; Group 5: cementum exposed to CS; and Group 6: cementum exposed to HT. The measurement of color change was conducted using a spectrophotometer. The surface alterations and mineral composition of enamel and cementum were evaluated using scanning electron microscopy and energy‐dispersive X‐ray spectroscopy. ANOVA test followed by Tukey's post hoc test was used to determine significant differences between groups.ResultsResults showed that CS had a more pronounced effect on enamel and cementum color changes than HT. The impact of CS and HT on color changes was more evident in cementum than in enamel. Surface morphology of enamel and cementum showed alterations in histology following exposure to both smoking types. Moreover, the mineral content experienced a significant reduction after using CS and HT. The reduction in calcium content after CS and HT exposure was similar. However, HT led to a significant decrease in the phosphorus content of enamel when compared with CS. At the same time, CS exposure in cementum resulted in a more significant reduction in Ca/P ratio than HT.ConclusionsAlthough HT may appear to present a lower danger to hard dental tissues than CS, it is not entirely harmless. CS results in more color changes on the enamel and cementum of teeth. Both smoking methods affected the mineral content of teeth, with CS having a significant effect on the roots, while HT significantly affected the crowns' mineral composition.
Sustainability of athletic field turf comparing organic and synthetic practices under two heights of cut
Authors: Dest William M. , Ebdon J. Scott 
Published: August 2024

AbstractLong‐term comparisons over several years between organic and synthetic management are lacking in sports turf research. Our objective was to investigate playing surface qualities and soil properties over an 8‐year period. For this trial, Kentucky bluegrass (KBG, Poa pratensis L.) sod was established and annually inter‐seeded with perennial ryegrass (Lolium perenne L.) and KBG. Factors included height of cut (3.2 and 6.4 cm) and management systems (MSs; synthetic and organic) with three replicates. Synthetic practices included chemical fertilizers and pesticides, while the organic system used hand‐weeding and biological fertilizers (leaf compost and naturally derived organics) with biological controls. In all years, wear was simulated in the fall using a slip‐wear machine and evaluated for playing qualities including visual wear tolerance, ball bounce (BB), surface hardness, and traction. Soil properties were evaluated in some years including pH, soil organic matter (SOM), soil bulk density, soil aggregate stability (SAG), and soil available P. Both MS received the same total N of 196 kg ha−1 year−1 but P applied varied with the MS (synthetic, 7.6 kg ha−1 year−1; organic, 23.2 kg ha−1 year−1). Synthetic practices provided acceptable visual wear tolerance (1–9, ≥6 acceptable) in 4 of 8 years compared to only 1 year for organic practices. Shorter cut grass (3.2 cm) consistently provided better visual wear tolerance (average = 5.6), harder surfaces (average = 51 g), and higher BB (average = 35.8%) consistent with accepted player standards. Synthetic practices afforded better tolerance to wear compared to organic practices in 5 of 8 years but little difference was observed in the other surface properties. Organic practices were consistently above 6.0 in soil pH (higher by 12%), 20% higher in soil available P, 25% higher in SOM, and with lower soil bulk density. SAG was higher following 8 years of simulated traffic by the last year of the test under organic practices. Results suggest competing benefits with synthetic practices affording better wear tolerance while organic practices promote better soil health.
Anlotinib potentiates anti‐PD1 immunotherapy via transferrin receptor‐dependent CD8+ T‐cell infiltration in hepatocellular carcinoma
Authors: Song Fei , Hu Bo , Liang Xiao‐Liang , Cheng Jian‐Wen , Wang Cheng‐Gui , Wang Peng‐Xiang , Wang Tian‐Lun , Tang Peng‐Ju , Sun Hai‐Xiang , Guo Wei , Zhou Jian , Fan Jia , Chen Zhong , Yang Xin‐Rong 
Published: August 2024

AbstractBackgroundThe therapeutic potential of immune checkpoint blockade (ICB) extends across various cancers; however, its effectiveness in treating hepatocellular carcinoma (HCC) is frequently curtailed by both inherent and developed resistance.ObjectiveThis research explored the effectiveness of integrating anlotinib (a broad‐spectrum tyrosine kinase inhibitor) with programmed death‐1 (PD‐1) blockade and offers mechanistic insights into more effective strategies for treating HCC.MethodsUsing patient‐derived organotypic tissue spheroids and orthotopic HCC mouse models, we assessed the effectiveness of anlotinib combined with PD‐1 blockade. The impact on the tumour immune microenvironment and underlying mechanisms were assessed using time‐of‐flight mass cytometry, RNA sequencing, and proteomics across cell lines, mouse models, and HCC patient samples.ResultsThe combination of anlotinib with an anti‐PD‐1 antibody enhanced the immune response against HCC in preclinical models. Anlotinib remarkably suppressed the expression of transferrin receptor (TFRC) via the VEGFR2/AKT/HIF‐1α signaling axis. CD8+ T‐cell infiltration into the tumour microenvironment correlated with low expression of TFRC. Anlotinib additionally increased the levels of the chemokine CXCL14, crucial for attracting CD8+ T cells. CXCL14 emerged as a downstream effector of TFRC, exhibiting elevated expression following the silencing of TFRC. Importantly, low TFRC expression was also associated with a better prognosis, enhanced sensitivity to combination therapy, and a favourable response to anti‐PD‐1 therapy in patients with HCC.ConclusionsOur findings highlight anlotinib's potential to augment the efficacy of anti‐PD‐1 immunotherapy in HCC by targeting TFRC and enhancing CXCL14‐mediated CD8+ T‐cell infiltration. This study contributes to developing novel therapeutic strategies for HCC, emphasizing the role of precision medicine in oncology.Highlights
Synergistic effects of anlotinib and anti‐PD‐1 immunotherapy demonstrated in HCC preclinical models.
Anlotinib inhibits TFRC expression via the VEGFR2/AKT/HIF‐1α pathway.
CXCL14 upregulation via TFRC suppression boosts CD8+ T‐cell recruitment.
TFRC emerges as a potential biomarker for evaluating prognosis and predicting response to anti‐PD‐1‐based therapies in advanced HCC patients.