bluuebunny/crossref_metadata_2025_split huggingface dataset:
The social and community opportunities profile social inclusion measure: Structural equivalence and differential item functioning in community mental health residents in Hong Kong and the United Kingdom
Authors: Huxley Peter John , Chan Kara , Chiu Marcus , Ma Yanni , Gaze Sarah , Evans Sherrill 
Published: October 2015

Introduction: China’s future major health problem will be the management of chronic diseases – of which mental health is a major one. An instrument is needed to measure mental health inclusion outcomes for mental health services in Hong Kong and mainland China as they strive to promote a more inclusive society for their citizens and particular disadvantaged groups. Aim: To report on the analysis of structural equivalence and item differentiation in two mentally unhealthy and one healthy sample in the United Kingdom and Hong Kong. Method: The mental health sample in Hong Kong was made up of non-governmental organisation (NGO) referrals meeting the selection/exclusion criteria (being well enough to be interviewed, having a formal psychiatric diagnosis and living in the community). A similar sample in the United Kingdom meeting the same selection criteria was obtained from a community mental health organisation, equivalent to the NGOs in Hong Kong. Exploratory factor analysis and logistic regression were conducted. Results: The single-variable, self-rated ‘overall social inclusion’ differs significantly between all of the samples, in the way we would expect from previous research, with the healthy population feeling more included than the serious mental illness (SMI) groups. In the exploratory factor analysis, the first two factors explain between a third and half of the variance, and the single variable which enters into all the analyses in the first factor is having friends to visit the home. All the regression models were significant; however, in Hong Kong sample, only one-fifth of the total variance is explained. Conclusion: The structural findings imply that the social and community opportunities profile–Chinese version (SCOPE-C) gives similar results when applied to another culture. As only one-fifth of the variance of ‘overall inclusion’ was explained in the Hong Kong sample, it may be that the instrument needs to be refined using different or additional items within the structural domains of inclusion.
A debate on the professional identity of occupational therapists
Authors: Turner Annie , Knight Judith 
Published: October 2015

Introduction The issue of occupational therapy’s professional identity has been debated for many years and continues today. Lack of clarity has resulted in occupational therapists’ perceptions of holding a low status and of colleague and public misunderstanding. Method A range of international literature was reviewed. Inductive analysis elicited two major themes – reasons for issues with identity and the consequences of issues with identity. The development of communities of practice is discussed. Results The analysis of the causes and consequences of issues with professional identity was used to suggest how the profession might become a mature community of practice. Lack of deep knowledge of the profession’s unique beliefs was shown to cause inconsistent messages about its identity. Consequently, practitioners believed they were undervalued. Understanding, owning and reinforcing an occupational paradigm were seen as vital elements for creating professional communities of practice. Conclusion To function as a community of practice requires occupational therapists to use a range of strategies that reinforce their unique occupation-based practice. Where all members commit to a single set of values and beliefs this can afford a unique identity, reinforced by the ability to demonstrate and articulate this through a clear, single message.
Term Limits and Collaboration Across the Aisle: An Analysis of Bipartisan Cosponsorship in Term Limited and Non-Term Limited State Legislatures
Authors: Swift Clint S. , VanderMolen Kathryn A. 
Published: October 2015

AbstractAs members of democratic institutions, state legislators must frequently collaborate with each other to achieve their varied goals. Given the increased attention to questions of polarization and gridlock, scholars should be particularly interested in understanding legislator decisions to collaborate across party lines. This article is primarily concerned with how institutional arrangements—specifically term limits—structure legislators' decisions to cosponsor bills with partisan opponents. Using data on bill cosponsorship from 41 states (82 chambers), we demonstrate that term limits reduce bipartisan cosponsorship even when controlling for average legislative tenure. We argue that term limits accomplish this by altering the incentives that legislators face. In addition, we demonstrate that the effect of term limits depends on the level of legislative professionalization. When professionalization is high, the negative effect of term limits on bipartisan cosponsorship is particularly pronounced.
Orbital Atherectomy Plaque Modification Assessment of the Femoropopliteal Artery Via Intravascular Ultrasound (TRUTH Study)
Authors: Babaev Anvar , Zavlunova Susanna , Attubato Michael J. , Martinsen Brad J. , Mintz Gary S. , Maehara Akiko 
Published: October 2015

Objective: The Tissue Removal Assessment with Ultrasound of the SFA and Popliteal (TRUTH) study assessed the performance of the orbital atherectomy system (OAS) to treat femoropopliteal arteries, including determining its effect on plaque removal. Methods: Patients with symptomatic femoropopliteal peripheral arterial disease were treated with the OAS followed by adjunctive balloon angioplasty (BA). Intravascular ultrasound (IVUS) images were collected pre- and post-OAS and post-OAS BA. Patients were followed through 12 months post-procedure. Results: Twenty-nine lesions were treated with OAS-BA in 25 patients. The mean maximum balloon inflation pressure was 5.2 ± 1.2 atm. Virtual histology IVUS (VH-IVUS) analysis revealed at the maximum calcium ablation site that calcium reduction was responsible for 86% of the lumen area increase. The minimum lumen area increased from 4.0 mm2 to 9.1 mm2 (<.0001), and the percentage of area stenosis decreased from 76.9% to 43.0% (<.0001) after OAS-BA. At 12 months, the target lesion revascularization rate was 8.2%, and ankle–brachial index and Rutherford classification improved significantly from baseline through follow-up. Conclusion: The VH-IVUS analysis reveals that OAS modifies the calcified component of the plaque burden. It is hypothesized that calcium modification by OAS changes the lesion compliance, allowing for low pressure adjunctive BA. The clinical outcomes were favorable through 12-month follow-up.
Mechanical thrombectomy in patients with acute basilar occlusion using stent retrievers
Authors: Carneiro Angelo António Silva , Rodrigues João Tiago Lopes , Pereira José Pedro Rocha , Alves José Viriato , Xavier João Abel Marques 
Published: October 2015

Background Early arterial recanalisation with stent retrievers (SR) has been recently demonstrated to improve clinical outcome of patients with large-vessel occlusion of the anterior circulation. However, the benefit of SR thrombectomy in the setting of acute basilar artery occlusion (BAO) has not been proven yet. This study evaluated a series of consecutive patients with BAO treated with SR, focusing on the efficacy, safety and clinical results. Methods We analysed 24 consecutive patients with acute BAO who were treated with SR mechanical thrombectomy. Good clinical outcome at three months was defined as mRS ≤ 2. Data from patients with good outcome were compared to that from patients with poor outcome. Results Sufficient recanalisation (TICI 2 b or 3) was achieved in 63% (15/24) of patients. At three months, 33% (8/24) of patients had died; good clinical outcome was obtained in 21% (5/24). Age (46 vs. 60 years old, p = 0.05) and time from symptoms onset to recanalisation (370 vs. 521 minutes, p = 0.048) was significantly lower in patients with good outcome as compared to patients with poor outcome. There were three cases (12.5%) of periprocedural complications, all of them related to arterial wall dissection/perforation. Conclusions SR thrombectomy might be an efficient and safe treatment for patients with acute BAO occlusion and might help improve outcome.
Pharmacomechanical thrombolysis with a rotator thrombolysis device in iliofemoral deep venous thrombosis
Authors: Karahan Oguz , Kutas H Barıs , Gurbuz Orcun , Tezcan Orhan , Caliskan Ahmet , Yavuz Celal , Demirtas Sinan , Mavitas Binali 
Published: October 2015

Objective Deep venous thrombosis (DVT) is a life-threatening and morbid pathology. This study aimed to investigate the efficacy of an early thrombolysis procedure using a rotator thrombolysis device. Methods Sixty-seven patients with acute proximal DVT were enrolled in the study. Patients’ data were recorded retrospectively. Initially, an infrarenal retrievable vena cava filter was placed through the femoral vein. Then, a rotator thrombolysis device and a thrombolytic agent injection were applied to the occluded segments of the deep veins by puncturing the popliteal vein. Results The identified reasons were trauma (43.3%), pregnancy (20.9%), undiagnosed (11.9%), major surgical operation (10.5%), immobilization (7.5%), and malignancy (5.9%). Immediate total recanalization was conducted in all patients, and the leg diameters returned to normal ranges in the early postoperative period. Hospital mortality or severe complications were not detected. Conclusion New thrombolytic devices seem to reduce in-hospital mortality risks and may potentially decrease post-thrombotic morbidity.
Impact of a nurse-led feeding protocol in a pediatric intensive care unit
Authors: Ang Bixia , Han Wee Meng , Wong Judith Ju-Ming , Lee Ang Noi , Chan Yoke Hwee , Lee Jan Hau 
Published: October 2015

Background: To determine effectiveness of a nurse-led, volume-based feeding protocol in our pediatric intensive care unit (PICU), we evaluated patients’ nutrition adequacy pre- and post-protocol implementation. Methods: We conducted an observational study of patients admitted for more than three days in the PICU during pre- and post-feeding protocol periods. We recorded energy and protein intake and feed interruptions in patients started on enteral nutrition over the first seven days of admission. We excluded patients with septic shock requiring more than two inotropes, post-cardiac and post-gastrointestinal surgeries. To determine nutrition adequacy, actual energy and protein intakes were compared with calculated requirements, expressed as percentages. Results: We had a total of 40 patients (20 in the pre- and post-protocol groups, respectively) with median age of 9.4 (interquartile range (IQR) 2.8, 57) months. Median time to feed initiation was similar between groups (20.0 (IQR 17.0, 37.5) vs. 21.5 (IQR 10.5, 27.0) hours, p = 0.516). There was no difference in median energy (55 (IQR 12, 102) vs. 59 (IQR 25, 85) %, p = 0.645) and protein intake (53 (IQR 16, 124) vs. 73 (IQR 22, 137) %, p = 0.069) over the seven-day period between groups; the proportion of patients meeting their energy (10 vs. 35%, p = 0.127) and protein goal (15 vs. 30%, p = 0.451) by day three also did not differ significantly pre- and post-protocol implementation. The most common reasons for feed interruption were intubation/extubation and radiological procedures. Conclusion: Our current feeding protocol did not improve nutrient adequacy. The effectiveness of a more aggressive protocol in units where enteral nutrition is initiated within 24 hours should be investigated.
Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia
Authors: Churpek Jane E. , Pyrtel Khateriaa , Kanchi Krishna-Latha , Shao Jin , Koboldt Daniel , Miller Christopher A. , Shen Dong , Fulton Robert , O’Laughlin Michelle , Fronick Catrina , Pusic Iskra , Uy Geoffrey L. , Braunstein Evan M. , Levis Mark , Ross Julie , Elliott Kevin , Heath Sharon , Jiang Allan , Westervelt Peter , DiPersio John F. , Link Daniel C. , Walter Matthew J. , Welch John , Wilson Richard , Ley Timothy J. , Godley Lucy A. , Graubert Timothy A. 
Published: October 2015

Key Points
Known pathogenic germ line variants in 12 genes can explain nearly 30% of families with inherited predisposition to MDS/AML. Asymptomatic carriers of germ line RUNX1 mutations develop detectable clonal hematopoiesis with a cumulative risk of >80% by age 50 years.
Impact of traditional culture on Camellia reticulata in Yunnan, China
Authors: Xin Tong , de Riek Jan , Guo Huijun , Jarvis Devra , Ma Lijuan , Long Chunlin 
Published: October 2015

Abstract
Background
Cha-hua (Camellia reticulata) is one of China’s traditional ornamental flowers developed by the local people of Yunnan Province. Today, more than 500 cultivars and hybrids are recognized. Many ancient camellia trees still survive and are managed by local peopl. A few records on cha-hua culture exist, but no studies expound the interaction between C. reticulata and traditional culture of ethnic groups. The contribution of traditional culture of different nationalities and regions to the diversity of Camellia reticulate is discussed.

Methods
Ethnobotanical surveys were conducted throughout Central and Western Yunnan to investigate and document the traditional culture related to Camellia reticulata. Five sites were selected to carry out the field investigation. Information was collected using participatory observation, semi-structured interviews, key informant interviews, focus group discussions, and participatory rural appraisal (PRA).

Results
Most of the ancient camellia trees were preserved or saved in the courtyards of old buildings and cultural or religious sites. Religion-associated culture plays an important role in C. reticulata protection. In every site we investigated, we found extensive traditional culture on C. reticulata and its management. These traditional cultures have not only protected the germplasm resources of C. reticulata, but also improved the diversity of Camellia cultivars.

Conclusions
There are abundant and diverse genetic resources of cha-hua, Camellia reticulata in Yunnan. Cha-hua is not only an ornamental flower but also has been endowed with rich spiritual connotation. The influence of traditional culture had improved the introduction and domestication of wild plants, breeding and selection of different varieties, and the propagation and dissemination of the tree in Yunnan. However, either some ancient cha-hua trees or their associated traditional culture are facing various threats. The old cha-hua trees and the ethnic camellia culture should be respected and protected since they have made great contributions in the history, and will make more contributions in the future.
Fluid balance and mortality in critically ill patients with acute kidney injury: a multicenter prospective epidemiological study
Authors: Wang Na , Jiang Li , Zhu Bo , Wen Ying , Xi Xiu-Ming ,   The Beijing Acute Kidney Injury Trial (BAKIT) Workgroup
Published: October 2015

Abstract
Introduction
Early and aggressive volume resuscitation is fundamental in the treatment of hemodynamic instability in critically ill patients and improves patient survival. However, one important consequence of fluid administration is the risk of developing fluid overload (FO), which is associated with increased mortality in patients with acute kidney injury (AKI). We evaluated the impact of fluid balance on mortality in intensive care unit (ICU) patients with AKI.

Methods
The data were extracted from the Beijing Acute Kidney Injury Trial. This trial was a prospective, observational, multicenter study conducted in 30 ICUs among 28 tertiary hospitals in Beijing, China, from 1 March to 31 August 2012. In total, 3107 patients were admitted consecutively, and 2526 patients were included in this study. The data from the first 3 sequential days were analyzed. The AKI severity was classified according to the Kidney Disease: Improving Global Outcomes guidelines. The daily fluid balance was recorded, and the cumulative fluid balance was registered at 24, 48, and 72 h. A multivariate analysis was performed with Cox regression to determine the impact of fluid balance on mortality in patients with AKI.

Results
Among the 2526 patients included, 1172 developed AKI during the first 3 days. The mortality was 25.7 % in the AKI group and 10.1 % in the non-AKI group (P < 0.001). The daily fluid balance was higher, and the cumulative fluid balance was significantly greater, in the AKI group than in the non-AKI group. FO was an independent risk factor for the incidence of AKI (odds ratio 4.508, 95 % confidence interval 2.900 to 7.008, P < 0.001) and increased the severity of AKI. Non-surviving patients with AKI had higher cumulative fluid balance during the first 3 days (2.77 [0.86–5.01] L versus 0.93 [−0.80 to 2.93] L, P < 0.001) than survivors did. Multivariate analysis revealed that the cumulative fluid balance during the first 3 days was an independent risk factor for 28-day mortality.

Conclusions
In this multicenter ICU study, the fluid balance was greater in patients with AKI than in patients without AKI. FO was an independent risk factor for the incidence of AKI and increased the severity of AKI. A higher cumulative fluid balance was an important factor associated with 28-day mortality following AKI.
Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis
Authors: Yang Weng-Lang , Sharma Archna , Zhang Fangming , Matsuo Shingo , Wang Zhimin , Wang Haichao , Wang Ping 
Published: October 2015

Abstract
Introduction
Sepsis involves overwhelming inflammatory responses with subsequent immune-suppression that can lead to multiple organ dysfunction and ultimately death. Milk fat globule epidermal growth factor-factor 8 (MFG-E8) is a secretory protein found to have multiple biological activities against autoimmune and inflammatory diseases. MFG-E8 contains an Arg-Gly-Asp (RGD) motif involved in cell-cell and cell-matrix interactions. In sepsis, excessive neutrophils migration through endothelial cells and matrix to sites of inflammation results in organ damage. We hypothesized that MFG-E8-derived short peptides (MSP) flanking its RGD motif could provide protection against organ injury in sepsis.

Methods
The differentiated human neutrophil-like HL-60 cells (dHL60) were incubated with a series of peptides flanking the RGD motif of human MFG-E8 for a cell adhesion assay to fibronectin or human pulmonary artery endothelial cells (PAECs). For the induction of sepsis, male C57BL/6 mice (20–25 g) were subjected to cecal ligation and puncture (CLP). Peptide MSP68 (1 mg/kg body weight) or normal saline (vehicle) was injected intravenously at 2 h after CLP. Blood and tissue samples were collected at 20 h after CLP for various measurements.

Results
After screening, peptide MSP68 (VRGDV) had the highest inhibition of dHL-60 cell adhesion to fibronectin by 55.8 % and to PAEC by 67.7 %. MSP68 treatment significantly decreased plasma levels of organ injury marker AST by 37.1 % and the proinflammatory cytokines IL-6 and TNF-α by 61.9 % and 22.1 %, respectively after CLP. MSP68 improved the integrity of microscopic architectures, decreased IL-6 levels in the lungs by 85.1 %, and reduced apoptosis. MSP68 treatment also significantly reduced the total number of neutrophil infiltration by 61.9 % and 48.3 % as well as MPO activity by 40.8 % and 47.3 % in the lungs and liver, respectively, after CLP. Moreover, the number of bacteria translocated to mesenteric lymph nodes was decreased by 57 % with MSP68 treatment. Finally, the 10-day survival rate was increased from 26 % in the vehicle group to 58 % in the MSP68-treated group.

Conclusions
MSP68 effectively inhibits excessive neutrophils infiltrating to organs, leading to moderate attenuation of organ injury and significantly improved survival in septic mice. Thus, MSP68 may be a potential therapeutic agent for treating sepsis.
Compression or expansion of dementia in Germany? An observational study of short-term trends in incidence and death rates of dementia between 2006/07 and 2009/10 based on German health insurance data
Authors: Doblhammer Gabriele , Fink Anne , Zylla Stephanie , Willekens Frans 
Published: October 2015

Abstract
Introduction
There have been recent reports about a decline in dementia incidence, but only little is known about trends in the mortality of patients with dementia. Only the simultaneous analysis of both trends can inform whether the reported decline in dementia has led to a compression of dementia into higher ages.

Methods
We used health claims data from the largest public health insurer in Germany over the two time periods 2004/07 and 2007/10. Dementia was defined according to the International Classification of Disease 10th revision (ICD-10) numbers G30, G31.0, G31.82, G23.1, F00, F01, F02, F03 and F05.1 or by a prescription of cholinesterase inhibitors or memantine or both. In the two time periods, we observed 502,065 person-years of exposure and 10,881 incident dementia cases and 10,013 person-years of exposure among the newly demented and 3049 deaths. We estimated the relative risks of the two time periods applying proportional hazard models and calculated years with or without dementia using the illness-death model.

Results
Dementia incidence was significantly higher in 2006/07 than in 2009/10, whereas mortality with dementia tended to be lower in the first period, albeit statistically significant among women only. Mortality without dementia tended to be higher in the first period for men and remained stable for women. Combining these trends, we found that at age 65 remaining life years with dementia were compressed by a yearly 0.4 months for men and 1.4 months for women. At the same time, remaining life years without dementia increased by a yearly 1.4 months for men and 1.1 months for women.

Conclusions
This study provides evidence that the increase in dementia-free life years went together with an absolute compression of life years with dementia. This positive trend was particularly strong among women. Results were controlled for trends in multi-morbidity and care need, suggesting that the postponement in dementia incidence is not simply caused by a delay in diagnosis.
Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan
Authors: Sun Yi-Hua , Nfor Oswald Ndi , Huang Jing-Yang , Liaw Yung-Po 
Published: October 2015

Abstract
Introduction
The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older.

Methods
Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer’s disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0.

Results
Individuals exposed to amalgam fillings had higher risk of Alzheimer’s disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer's disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women.

Conclusions
Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer’s disease than were their non-exposed counterparts.