bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking Cd(II) biosorption potential of Candida tropicalis XTA 1874 for sustainable wastewater treatment
Authors: Bhattacharyya Kaustav , Bhattacharjee Neelanjan , Sen Debrup , Lai Tapan Kumar , Ghosh Ananyo K. , Pal Ritesh Ranjan , Ganguly Subhadeep 
Published: July 2024

AbstractCd(II) is a potentially toxic heavy metal having carcinogenic activity. It is becoming widespread in the soil and groundwater by various natural and anthropological activities. This is inviting its immediate removal. The present study is aimed at developing a Cd(II) resistant strain isolated from contaminated water body and testing its potency in biological remediation of Cd(II) from aqueous environment. The developed resistant strain was characterized by SEM, FESEM, TEM, EDAX, FT-IR, Raman Spectral, XRD and XPS analysis. The results depict considerable morphological changes had taken place on the cell surface and interaction of Cd(II) with the surface exposed functional groups along with intracellular accumulation. Molecular contribution of critical cell wall component has been evaluated. The developed resistant strain had undergone Cd(II) biosorption study by employing adsorption isotherms and kinetic modeling. Langmuir model best fitted the Cd(II) biosorption data compared to the Freundlich one. Cd(II) biosorption by the strain followed a pseudo second order kinetics. The physical parameters affecting biosorption were also optimized by employing response surface methodology using central composite design. The results depict remarkable removal capacity 75.682 ± 0.002% of Cd(II) by the developed resistant strain from contaminated aqueous medium using 500 ppm of Cd(II). Quantitatively, biosorption for Cd(II) by the newly developed resistant strain has been increased significantly (p < 0.0001) from 4.36 ppm (non-resistant strain) to 378.41 ppm (resistant strain). It has also shown quite effective desorption capacity 87.527 ± 0.023% at the first desorption cycle and can be reused effectively as a successful Cd(II) desorbent up to five cycles. The results suggest that the strain has considerable withstanding capacity of Cd(II) stress and can be employed effectively in the Cd(II) bioremediation from wastewater.
Investigating the causal association between obesity and risk of hepatocellular carcinoma and underlying mechanisms
Authors: Chen Zhitao , Ding Chenchen , Chen Kailei , Gu Yangjun , Qiu Xiaoxia , Li Qiyong 
Published: July 2024

AbstractObesity is a global health concern and independent risk factor for cancers including hepatocellular carcinoma (HCC). However, evidence on the causal links between obesity and HCC is limited and inconclusive. This study aimed to investigate the causal relationship between obesity-related traits and HCC risk and explore underlying mechanisms using bioinformatics approaches. Two-sample Mendelian randomization analysis was conducted leveraging publicly available genome-wide association study summary data on obesity traits (body mass index, body fat percentage, waist circumference, waist-to-hip ratio, visceral adipose tissue volume) and HCC. Associations of obesity with primary mechanisms (insulin resistance, adipokines, inflammation) and their effects on HCC were examined. Differentially expressed genes in obesity and HCC were identified and functional enrichment analyses were performed. Correlations with tumor microenvironment (TME) and immunotherapy markers were analyzed. Genetically predicted higher body mass index and body fat percentage showed significant causal relationships with increased HCC risk. Overall obesity also demonstrated causal links with insulin resistance, circulating leptin levels, C-reactive protein levels and risk of severe insulin resistant type 2 diabetes. Four differentially expressed genes (ESR1, GCDH, FAHD2A, DCXR) were common in obesity and HCC. Enrichment analyses indicated their roles in processes like RNA capping, viral transcription, IL-17 signaling and endocrine resistance. They exhibited negative correlations with immune cell infiltration and immunotherapy markers in HCC. Overall obesity likely has a causal effect on HCC risk in Europeans, possibly via influencing primary mechanisms. The identified differentially expressed genes may be implicated in obesity-induced hepatocarcinogenesis through regulating cell cycle, inflammation and immune evasion. Further research on precise mechanisms is warranted.
Characteristics of retinal vascularization in reactivated retinopathy of prematurity requiring treatment and clinical outcome after reinjection of ranibizumab
Authors: Jang Ji Hye 
Published: July 2024

AbstractThis study aimed to determine whether the state of retinal vascularization after anti-vascular endothelial growth factor (anti-VEGF) injection can help predict the risk of reactivated retinopathy of prematurity (ROP) requiring treatment and whether repeated ranibizumab injection will be effective in such cases. We retrospectively reviewed 24 infants (43 eyes) who received ranibizumab monotherapy between January 2021 and December 2022. All eyes were classified as having non-retreated ROP or retreated ROP. The state of ROP at the time of treatment, the time required for resolution of plus disease, and the extent of vascularization at 4 and 8 weeks after treatment were analyzed. Extent of temporal retinal vascularization was measured with serial fundus images using disc-fovea distance (DF) unit and disc diameter (DD). Reactivated ROP requiring treatment occurred in six infants (25.0%) and ten eyes (23.3%) after ranibizumab treatment. The mean retreatment interval was 9.0 ± 3.3 weeks (range 4–16). In the retreated ROP group, the time required for the resolution of plus disease after primary injection was longer compared to the control group (13.3 days vs 5.2 days), with a mean ROP regression time of 3.4 weeks. All eyes in the retreated ROP showed retinal vascularization < 0.5 DF from the original site at 4 weeks after injection. In 90% of cases with retreated ROP, the extent of vascularization at 8 weeks after injection was within 1 DF from the original ROP site, and all cases showed reactivation in the posterior Zone II area. The extent of retinal neovascularization in the retreated group was an average of 0.7 DD (vs 1.7 DD) and 1.3 DD (vs 3.3 DD) at 4 and 8 weeks after injection, respectively. After ranibizumab retreatment, only one reactivated case with vitreous traction progressed to focal retinal detachment, while all other cases regressed with peripheral vascular development. The continuation of delayed retinal blood vessel development after ≥ 8 weeks may indicate a high likelihood of reactivated ROP requiring treatment. In the absence of vitreous traction, ranibizumab reinjection is likely to be effective in treating reactivated ROP requiring treatment.
Extracellular C1qbp inhibits myogenesis by suppressing NFATc1
Authors: Kim Jin-Man , Kim Ho Kyoung , Cho Han Jin , Moon Sung-Ah , Kim Yewon , Hong Jeong Yeon , Lee Seung Hun , Kim Kyunggon , Koh Jung-Min 
Published: July 2024

AbstractAging and lack of exercise are the most important etiological factors for muscle loss. We hypothesized that new factors that contribute to muscle loss could be identified from ones commonly altered in expression in aged and exercise-limited skeletal muscles. Mouse gastrocnemius muscles were subjected to mass spectrometry-based proteomic analysis. The muscle proteomes of hindlimb-unloaded and aged mice were compared to those of exercised and young mice, respectively. C1qbp expression was significantly upregulated in the muscles of both hindlimb-unloaded and aged mice. In vitro myogenic differentiation was not affected by altering intracellular C1qbp expression but was significantly suppressed upon recombinant C1qbp treatment. Additionally, recombinant C1qbp repressed the protein level but not the mRNA level of NFATc1. NFATc1 recruited the transcriptional coactivator p300, leading to the upregulation of acetylated histone H3 levels. Furthermore, NFATc1 silencing inhibited p300 recruitment, downregulated acetylated histone H3 levels, and consequently suppressed myogenic differentiation. The expression of C1qbp was inversely correlated with that of NFATc1 in the gastrocnemius muscles of exercised or hindlimb-unloaded, and young or aged mice. These findings demonstrate a novel role of extracellular C1qbp in suppressing myogenesis by inhibiting the NFATc1/p300 complex. Thus, C1qbp can serve as a novel therapeutic target for muscle loss.
Comparison of WAIC and posterior predictive approaches for N-mixture models
Authors: Gaya Heather E. , Ketz Alison C. 
Published: July 2024

AbstractHierarchical models are common for ecological analysis, but determining appropriate model selection methods remains an ongoing challenge. To confront this challenge, a suitable method is needed to evaluate and compare available candidate models. We compared performance of conditional WAIC, a joint-likelihood approach to WAIC (WAICj), and posterior-predictive loss for selecting between candidate N-mixture models. We tested these model selection criteria on simulated single-season N-mixture models, simulated multi-season N-mixture models with temporal auto-correlation, and three case studies of single-season N-mixture models based on eBird data. WAICj proved more accurate than the standard conditional formulation or posterior-predictive loss, even when models were temporally correlated, suggesting WAICj is a robust alternative to model selection for N-mixture models.
Blockchain technology and raft consensus for secure physician prescriptions and improved diagnoses in electronic healthcare systems
Authors: Abdorrahimi Behnaz , Nekouie Atefeh , Rahmani Amir Masoud , Lansky Jan , Nulíček Vladimír , Hosseinzadeh Mehdi , Moattar Mohammad Hossein 
Published: July 2024

AbstractWith electronic healthcare systems undergoing rapid change, optimizing the crucial process of recording physician prescriptions is a task with major implications for patient care. The power of blockchain technology and the precision of the Raft consensus algorithm are combined in this article to create a revolutionary solution for this problem. In addition to addressing these issues, the proposed framework, by focusing on the challenges associated with physician prescriptions, is a breakthrough in a new era of security and dependability for the healthcare sector. The Raft algorithm is a cornerstone that improves the diagnostic decision-making process, increases confidence in patients, and sets a new standard for robust healthcare systems. In the proposed consensus algorithm, a weighted sum of two influencing factors including the physician acceptability and inter-physicians’ reliability is used for selecting the participating physicians. An investigation is conducted to see how well the Raft algorithm performs in overcoming prescription-related roadblocks that support a compelling argument for improved patient care. Apart from its technological benefits, the proposed approach seeks to revolutionize the healthcare system by fostering trust between patients and providers. Raft’s ability to communicate presents the proposed solution as an effective way to deal with healthcare issues and ensure security.
The ethics of ChatGPT in medicine and healthcare: a systematic review on Large Language Models (LLMs)
Authors: Haltaufderheide Joschka , Ranisch Robert 
Published: July 2024

AbstractWith the introduction of ChatGPT, Large Language Models (LLMs) have received enormous attention in healthcare. Despite potential benefits, researchers have underscored various ethical implications. While individual instances have garnered attention, a systematic and comprehensive overview of practical applications currently researched and ethical issues connected to them is lacking. Against this background, this work maps the ethical landscape surrounding the current deployment of LLMs in medicine and healthcare through a systematic review. Electronic databases and preprint servers were queried using a comprehensive search strategy which generated 796 records. Studies were screened and extracted following a modified rapid review approach. Methodological quality was assessed using a hybrid approach. For 53 records, a meta-aggregative synthesis was performed. Four general fields of applications emerged showcasing a dynamic exploration phase. Advantages of using LLMs are attributed to their capacity in data analysis, information provisioning, support in decision-making or mitigating information loss and enhancing information accessibility. However, our study also identifies recurrent ethical concerns connected to fairness, bias, non-maleficence, transparency, and privacy. A distinctive concern is the tendency to produce harmful or convincing but inaccurate content. Calls for ethical guidance and human oversight are recurrent. We suggest that the ethical guidance debate should be reframed to focus on defining what constitutes acceptable human oversight across the spectrum of applications. This involves considering the diversity of settings, varying potentials for harm, and different acceptable thresholds for performance and certainty in healthcare. Additionally, critical inquiry is needed to evaluate the necessity and justification of LLMs’ current experimental use.
Global prevalence and correlates of mpox vaccine acceptance and uptake: a systematic review and meta-analysis
Authors: Sulaiman Sahabi Kabir , Isma’il Tsiga-Ahmed Fatimah , Musa Muhammad Sale , Makama Bello Tijjani , Sulaiman Abdulwahab Kabir , Abdulaziz Tijjani Bako 
Published: July 2024

AbstractBackgroundVaccination has been recommended as one of the most potent ways of controlling the mpox (formerly, monkeypox) outbreak, particularly among high-risk groups. Here, we evaluated the prevalence of mpox vaccine acceptance and uptake globally.MethodsWe searched multiple databases for peer-reviewed studies published in English from May 2022 to 25th November 2023 that evaluated mpox vaccine acceptance and/or uptake. We fit a random-effects model meta-analysis to calculate the pooled mpox vaccine acceptance and uptake rates, with their 95% confidence intervals (CI) across population outcomes. We performed subgroup analyses among the six World Health Organization (WHO) regions (Africa [AFR], Region of the Americas [AMR], South-East Asia Region [SEAR], European Region [EUR], Eastern Mediterranean Region [EMR], and the Western Pacific Region [WPR]), as well as among select population subgroups.ResultsOf the 2531 studies screened, 61 studies, with a cumulative sample size of 263,857 participants from 87 countries were eligible for inclusion. The overall vaccine acceptance and uptake rates were 59.7% and 30.9% globally. Acceptance and uptake rates among the LGBTQI+ community were 73.6% vs 39.8% globally, 60.9% vs. 37.1% in AMR, 80.9% vs. 50.0% in EUR, and 75.2% vs. 33.5% in WPR. Among PLHIV, vaccine acceptance and uptake rates were 66.4% vs. 35.7% globally, 64.0% vs. 33.9% in AMR, 65.1% vs. 27.0% in EUR, and 69.5% vs. 46.6% in WPR. Among healthcare workers, vaccination intention was 51.0% globally.ConclusionsTailored interventions are needed to bolster confidence in the mpox vaccine, maximize vaccine uptake, and increase vaccine access to close the gaps between acceptance and uptake especially among key populations residing in regions with low rates of acceptance and uptake.
Mesh‐free Monte Carlo method for electrostatic problems with floating potentials
Authors: Yin Wenjing , Wang Yunqing , Deng Hong , Wang Jiawei , Gao Xiaoke , Huang Ruoyu , He Kun , Chen Weijiang , Dong Tianyu 
Published: July 2024

AbstractNumerical simulation plays a crucial role in the analysis and design of power equipment, such as lightning protection devices, which may become inefficient using traditional grid‐based methods when handling complex geometries of large problems. The authors propose a grid‐free Monte Carlo method to handle electrostatic problems of complex geometry for both the interior and exterior domains, which is governed by the Poisson equation with a floating potential boundary condition that is neither a pure Dirichlet nor a Neumann condition. The potential and gradient at any given point can be expressed in terms of integral equations, which can be estimated recursively within the walk‐on‐sphere algorithm. Numerical examples have been demonstrated, including the evaluation of the mutual capacitance matrix of multi‐conductor structures and lighting striking near real fractal trees. The proposed method shows advantages in terms of geometric flexibility and robustness, output sensitivity, and parallelism, which may become a candidate for game‐changing numerical methods and exhibit great potential applications in high‐voltage engineering.
A domain adaptation‐based convolutional neural network incorporating data augmentation for power system dynamic security assessment
Authors: Azad Sasan , Ameli Mohammad Taghi 
Published: July 2024

AbstractRecently, deep learning (DL) based dynamic security assessment (DSA) methods have been very successful. However, although a DSA model can be trained well for a specific topology, it often does not perform well for other topologies. Since the topology in real‐world power systems is frequently changing, the performance reduction of DL‐based DSA methods is very serious, which is a challenging and urgent problem. This paper proposes a novel DSA method based on a convolutional neural network (CNN) to solve this problem. In the proposed method, a strong yet simple domain adaptation approach named adaptive batch normalization (AdaBN) is used, which significantly enhances the extensibility and generalizability of the DSA model when the topology changes and eliminates the need to train a large number of models. This approach achieves a deep adaptation effect by modulating the statistics from the source domain to the target domain in all batch normalization layers across the model. Unlike other domain adaptation methods, this method is parameter‐free, requires no additional components, and has advanced performance despite its simplicity. In addition, this paper introduces TGAN‐based data augmentation to deal with the difficulty of costly data collection and labelling. This data augmentation makes the proposed model applicable to small databases. The test results of the proposed method on IEEE 39‐bus and IEEE 118‐bus systems show that this method can evaluate system dynamic security during topology changes and in the face of data noise with high accuracy.
Bedeutung der stationären Rehabilitation von Kindern und Jugendlichen
mit Adipositas
Authors: Gellhaus Ines , Prinz Nicole , Neugebauer Friederike , Stachow Rainer , Falkenberg Christian , Gerber Doris , Heber Kirstin , Heß Juliane , Pellarin-Schlingensiepen Maike , Puch-Kapst Kathrin , Schiel Ralf , Schmelzle Hansjörg , Schmiederer Gerda , Volmer-Berthele Nora , W. Holl Reinhard 
Published: July 2024

ZusammenfassungDiese Arbeit stellt die spezifischen Daten aus der
Adipositas-Patienten-Verlaufsdokumentation (APV) von Kindern und Jugendlichen
mit Adipositas, die in stationären Rehabilitationskliniken behandelt werden, in
den Gesamtzusammenhang der vorliegenden Statistiken der Deutschen
Rentenversicherung (DRV). Die stationäre Rehabilitation spielt sowohl
quantitativ als auch qualitativ eine wichtige Rolle in der multiprofessionellen
Versorgung von Kindern und Jugendlichen mit Adipositas. Sie gehört in den
Kontext einer lebenslangen Behandlungskette von (noch auszubauenden) ambulanten
uni- oder multimodalen Angeboten und Nachsorgen für die chronische Erkrankung
Adipositas.
Tumoröse Kalzinose – Morbus Teutschländer – am Ringfingergrundgelenk
Authors: Waltenspül Claudia , Spies Christian Karl , Janzen Jan 
Published: July 2024

ZusammenfassungEine 51-jährige Patientin präsentierte sich mit einer druckdolenten Schwellung palmar über dem Metakarpophalangealgelenk des Ringfingers. Konventionell radiologisch und kernspintomografisch zeigte sich eine einzelne abgerundete Raumforderung. Nach operativer Exzision und histologischer Aufarbeitung erfolgte die Diagnosestellung der seltenen tumorösen Kalzinose (Synonym: Morbus Teutschländer).
Flow Diversion for the Treatment of Middle Cerebral Artery Aneurysms
Authors: Schüngel Marie-Sophie , Wohlgemuth Walter A , Elolf Erck , Rensch Leonhard , Brill Richard , Schob Stefan 
Published: July 2024

AbstractThe invention of flow diverting stents (FDS) is a novel milestone in the field of endovascular aneurysm therapy, promoting physiological healing of the vessel segment contrary to prior deconstructive treatment strategies, such as coiling. The effects of FDS are based on changes in flow patterns, segmental wall stabilization, and the growth of a neointima. Although flow diversion is already well established for cerebral aneurysms in proximal segments, peripheral locations remain challenging. Especially the middle cerebral artery (MCA) with its predominance of non-collateralized perforators and functional end arteries that supply the eloquent areas of the brain is of major concern.The literature was reviewed for flow diversion of the MCA and antiplatelet therapy.Resulting from the special anatomical characteristics of the MCA, FDS implantation in this territory is completely different from the proximal vessel segments. Still, flow diversion represents an effective endovascular strategy, especially in otherwise non-accessible or sufficiently treatable lesions. However, the risk of ischemic adverse events might be increased. Special attention to the individual decision regarding device selection, antiplatelet regimen, and exact definition of the proximal and distal landing zone considering the jailed side branches is essential for a good angiographic and clinical outcome.
Historical Perspective of Homeopathy in the Brazilian Public Health System
Authors: da Costa Fujino Fernanda Maria Simões , de Eston Armond Jane , Ribeiro Ana Paula , de Souza Patrícia Colombo 
Published: July 2024

AbstractHomeopathy was introduced in Brazil with the French doctor Benoît Jules Mure's arrival in 1840 and was officially recognised in 1980 as a medical specialty by Brazilian regulatory authorities. Public health policies played an important role in incorporating homeopathy into the Brazilian Unified Health System (SUS), emphasising homeopathy's coherence with SUS's fundamental principles and with other national health policies. Homeopathy is supported by the guidelines of the National Primary Health Care Policy and the National Policy on Integrative and Complementary Practices, and its offer in the SUS has been recognised since 2006. Challenges persist, however, such as the low prevalence of the use of homeopathy, lack of investment in professional training and under-reporting of homeopathy outpatient appointments. Investments in disseminating information on homeopathic philosophy and raising awareness among managers and health professionals are essential to strengthen its presence in the Brazilian public health system.