bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coevolution (Or Not) of Supermassive Black Holes and Host Galaxies
Authors: Kormendy John , Ho Luis C. 
Published: August 2013

Supermassive black holes (BHs) have been found in 85 galaxies by dynamical modeling of spatially resolved kinematics. The Hubble Space Telescope revolutionized BH research by advancing the subject from its proof-of-concept phase into quantitative studies of BH demographics. Most influential was the discovery of a tight correlation between BH mass [Formula: see text] and the velocity dispersion σ of the bulge component of the host galaxy. Together with similar correlations with bulge luminosity and mass, this led to the widespread belief that BHs and bulges coevolve by regulating each other's growth. Conclusions based on one set of correlations from [Formula: see text] in brightest cluster ellipticals to [Formula: see text] in the smallest galaxies dominated BH work for more than a decade.New results are now replacing this simple story with a richer and more plausible picture in which BHs correlate differently with different galaxy components. A reasonable aim is to use this progress to refine our understanding of BH-galaxy coevolution. BHs with masses of 105−106M⊙are found in many bulgeless galaxies. Therefore, classical (elliptical-galaxy-like) bulges are not necessary for BH formation. On the other hand, although they live in galaxy disks, BHs do not correlate with galaxy disks. Also, any [Formula: see text] correlations with the properties of disk-grown pseudobulges and dark matter halos are weak enough to imply no close coevolution.The above and other correlations of host-galaxy parameters with each other and with [Formula: see text] suggest that there are four regimes of BH feedback. (1) Local, secular, episodic, and stochastic feeding of small BHs in largely bulgeless galaxies involves too little energy to result in coevolution. (2) Global feeding in major, wet galaxy mergers rapidly grows giant BHs in short-duration, quasar-like events whose energy feedback does affect galaxy evolution. The resulting hosts are classical bulges and coreless-rotating-disky ellipticals. (3) After these AGN phases and at the highest galaxy masses, maintenance-mode BH feedback into X-ray-emitting gas has the primarily negative effect of helping to keep baryons locked up in hot gas and thereby keeping galaxy formation from going to completion. This happens in giant, core-nonrotating-boxy ellipticals. Their properties, including their tight correlations between [Formula: see text] and core parameters, support the conclusion that core ellipticals form by dissipationless major mergers. They inherit coevolution effects from smaller progenitor galaxies. Also, (4) independent of any feedback physics, in BH growth modes 2 and 3, the averaging that results from successive mergers plays a major role in decreasing the scatter in [Formula: see text] correlations from the large values observed in bulgeless and pseudobulge galaxies to the small values observed in giant elliptical galaxies.
Analysis and Characterization of Probability Distribution and Small-Scale Spatial Variability of Rainfall in Singapore Using a Dense Gauge Network
Authors: Mandapaka Pradeep V. , Qin Xiaosheng 
Published: August 2013

AbstractHourly rainfall measurements from a network of 49 rain gauges on the tropical island of Singapore are analyzed to characterize variability of rainfall for temporal and spatial scales ranging from 1 to 24 h and from 1 to 45 km, respectively. First, the probability distributions of rain rates are characterized using the method ofLmoments. The analysis showed that the Pearson type-3 (PE3) distribution best fitted the rain rates for all time scales of concern. The parameters of the PE3 distribution are found to be related to the time scale through simple power laws. Second, the spatial structure of rainfall is characterized using spatial correlations. The decay of correlations with intergauge distance is parameterized using a powered-exponential function. In general, thee-folding correlation distance (distance at which the correlation drops to 1/e) varied from 10 km at hourly scales to 33 km at daily scales. The study also examined diurnal, seasonal, and anisotropic patterns in the spatial correlation structure of rainfall. The rainfall patterns are smoothest in December and January and are most variable in February, April, and October. Diurnal analysis of spatial correlations showed that the rainfall patterns are smoothest in the early hours between 0100 and 0600 local time and are most variable during the afternoon between 1500 and 1900 local time. The results also showed complex anisotropic patterns in spatial correlations, with considerable dependence of rainfall orientation on spatial scale and the time of the year.
Downscaling of GCM-Simulated Precipitation Using Model Output Statistics
Authors: Eden Jonathan M. , Widmann Martin 
Published: August 2013

AbstractProducing reliable estimates of changes in precipitation at local and regional scales remains an important challenge in climate science. Statistical downscaling methods are often utilized to bridge the gap between the coarse resolution of general circulation models (GCMs) and the higher resolutions at which information is required by end users. As the skill of GCM precipitation, particularly in simulating temporal variability, is not fully understood, statistical downscaling typically adopts a perfect prognosis (PP) approach in which high-resolution precipitation projections are based on real-world statistical relationships between large-scale atmospheric predictors and local-scale precipitation. Using a nudged simulation of the ECHAM5 GCM, in which the large-scale weather states are forced toward observations of large-scale circulation and temperature for the period 1958–2001, previous work has shown ECHAM5 skill in simulating temporal variability of precipitation to be high in many parts of the world. Here, the same nudged simulation is used in an alternative downscaling approach, based on model output statistics (MOS), in which statistical corrections are derived for simulated precipitation. Cross-validated MOS corrections based on maximum covariance analysis (MCA) and principal component regression (PCR), in addition to a simple local scaling, are shown to perform strongly throughout much of the extratropics. Correlation between downscaled and observed monthly-mean precipitation is as high as 0.8–0.9 in many parts of Europe, North America, and Australia. For these regions, MOS clearly outperforms PP methods that use temperature and circulation as predictors. The strong performance of MOS makes such an approach to downscaling attractive and potentially applicable to climate change simulations.
Conservative management of laryngeal dog bite*
Authors: Oozeer NB , Fairgrieve R , Clement WA 
Published: August 2013

Background and aims Dog bites represent an important public health issue, causing injuries from trivial to fatal. The true incidence is unknown due to the lack of national and local reporting system. School children, mostly male, are more commonly affected with the majority of injuries occurring in the head and neck area, followed by the limbs and trunk. Methods The conservative management of a 6-year-old girl who sustained a fracture of her laryngeal structure from an attack by her neighbours’ dog is described. Only a 1 cm visible puncture wound in the midline of her neck with air escaping through the wound was seen at presentation. Results Ten days were spent in hospital including the first four in intubated Paediatric Intensive Care Unit. Initial microlaryngoscopy and bronchoscopy (MLB) showed a swelling in the right anterior subglottis not reducible by manipulation. She was re-intubated with progressively larger naso-tracheal tube until the fracture was fully reduced on her 3rd MLB. Three months post-injury, there is no evidence of airway narrowing. Conclusion The literature advocates early surgical management of laryngeal trauma including dog bites. Conservative management of laryngeal fracture from a dog bite is feasible and associated with a good outcome and no long-term sequela.
Intravitreal bevacizumab for the treatment of retinopathy of prematurity: a case report
Authors: Flavahan PW , Lavy TE , Wykes W 
Published: August 2013

Objective We report the first case in Scotland of a premature infant treated for retinopathy of prematurity with bevacizumab. Method A case report and a review of the literature are presented. Results Retinopathy of prematurity is a leading worldwide cause of childhood blindness. Conventional laser treatment results in destruction of the peripheral retina and does not prevent all cases of vision loss, particularly in Zone I disease. We present the case of a baby born at 26+3 weeks who developed stage 3+ disease located in Zone I of the retina. The patient was treated with bilateral bevacizumab injections and achieved complete resolution of his retinopathy. Conclusion Bevacizumab therapy for the treatment of retinopathy of prematurity is an effective and inexpensive treatment that can readily and quickly be administered by a competent ophthalmologist without the need for specialist equipment.
The effect of magnesium administration on erythrocyte transketolase activity in alcoholic patients treated with thiamine
Authors: Peake RWA , Godber IM , Maguire D 
Published: August 2013

Background and aims Chronic alcoholic patients are at increased risk of developing deficiencies of thiamine and magnesium. Thiamine is an essential co-factor for a number of enzymes involved in carbohydrate metabolism and requires optimal levels of magnesium for biological function. However, whilst thiamine supplementation is well established for the treatment of alcoholic patients, the importance of magnesium is often overlooked. We describe the effect of concurrent thiamine and magnesium administration on the activity of the thiamine-dependent enzyme erythrocyte transketolase in a cohort of chronic alcoholic patients. Methods Baseline erythrocyte transketolase activities were measured on blood samples collected from 36 chronic alcoholic patients presenting acutely to the Accident and Emergency department. Patients received either intravenous Pabrinex (thiamine) supplemented with magnesium sulphate ( n = 18) or Pabrinex only ( n = 18). Post-treatment bloods were collected for re-assessment of erythrocyte transketolase activity. The change in transketolase activities (pre-vs. post-treatment) between the two patient groups were compared by Mann-Whitney U test. Results The increase in transketolase activity following treatment in the cohort receiving Pabrinex supplemented with magnesium sulphate was significantly greater ( p = 0.018) than that produced in the cohort receiving Pabrinex alone. Conclusion In the acute management of a sample of chronic alcoholic patients, those receiving magnesium sulphate with Pabrinex have higher increases in erythrocyte transketolase activity compared with those receiving Pabrinex alone. We conclude that concurrent magnesium administration with Pabrinex may be required for enabling full efficacy of Pabrinex treatment, as demonstrated by its positive effect on erythrocyte transketolase activity.
The suspected scaphoid injury: resource implications in the absence of magnetic resonance imaging
Authors: Burns MJ , Aitken SA , McRae D , Duckworth AD , Gray A 
Published: August 2013

Introduction Undiagnosed and untreated scaphoid fractures have poorer outcomes and many patients are unnecessarily immobilised for prolonged periods of time to avoid missing occult injuries. Magnetic resonance imaging has a high sensitivity and specificity in detecting occult scaphoid fractures, but many units do not routinely use this imaging modality in the diagnostic pathway. We aimed to determine the patterns of suspected scaphoid injuries, report the process of care, and calculate the costs involved in their management. Methods We prospectively identified all adult patients referred to fracture clinic at the Royal Infirmary of Edinburgh with a scaphoid-related injury, between October 2007 and September 2008. Clinical notes were examined retrospectively. We defined three injury groups: true fractures, occult fractures, and suspected scaphoid injuries. We analysed patient demographics, treatment timelines, and the treatment costs involved. Results Fracture clinic received 537 scaphoid-related referrals. There were 87 true fractures, 43 occult fractures, and 407 suspected injuries, incurring average treatment costs of £1,173, £773, and £384 respectively. Occult fractures accounted for 33% of all confirmed scaphoid fractures. The majority of scaphoid-related referrals (76%) were never proven to have a scaphoid fracture, and many were unnecessarily immobilised. The costs involved in the treatment of suspected scaphoid injuries were found to be higher than the cost of magnetic resonance imaging (£97). Conclusion In this group of suspected scaphoid injury, we believe the introduction of an early magnetic resonance imaging protocol would lead to an earlier definitive diagnosis and potentially a more cost-effective service.
Direct access colonoscopy in primary care: is it a safe and practical approach?
Authors: Ahmed J , Mehmood S , Khan SA , Rao MM 
Published: August 2013

Background Implementation of colorectal cancer screening programme and provision of cancer service within certain timeframe has significantly increased the workload on endoscopy services. Direct access colonoscopy in primary care centers helps offload burden on conventional colonoscopy in secondary care, thereby reducing waiting times. The aim of this study was to assess the safety and efficacy of direct access colonoscopy service. Materials and methods Provision of colonoscopy service in our healthcare trust was analysed retrospectively during a two-year period. Safety and feasibility of direct access colonoscopy was analysed against conventional colonoscopy. The groups were compared for findings at colonoscopy, procedural outcomes, and complications. Results A total of 3468 colonoscopies were analysed. Of those, 1189(34.3%) were performed as direct access colonoscopy and 2279(65.7%) as conventional colonoscopy. No abnormality was detected in 408/1189(34.3%) and 825/2279(36.2%) patients in the direct access colonoscopy and conventional colonoscopy groups, respectively ( p = 0.52). Colorectal cancer detection rate was similar between the groups; conventional colonoscopy vs direct access colonoscopy, 3.1% (68/2279) vs 3.2% (39/1189) ( p = 0.85). However, there was significantly higher detection rate of polyps greater than 1 cm in conventional colonoscopy group compared to direct access colonoscopy group, 22.6%(518/2289) vs 12.6% (150/1189) ( p = 0.02). Complication rates were comparable between the groups. Conclusion Direct access colonoscopy in primary care centers is safe and feasible. Colorectal cancer detection remains comparable to that of conventional colonoscopy in secondary care despite relatively lower polyp detection rate.
Hepatitis E: the West of Scotland experience
Authors: Deshpande A , Gunson R , Bradley A , Cameron S 
Published: August 2013

Background and aims Hepatitis E virus is traditionally regarded as a virus of the developing world and is emerging as a leading cause of non-A/B/C hepatitis. We wished to investigate locally acquired transmission of hepatitis E in the West of Scotland and compare our use of traditional serology versus polymerase chain reaction since the introduction of polymerase chain reaction in 2007. Methods Clinical details provided on specimens of blood positive for hepatitis E virus by serology or polymerase chain reaction were collated and analysed. Results Since 2007, 30 samples were hepatitis E virus-positive by serology or polymerase chain reaction. Polymerase chain reaction positivity was generally associated with positive serology although four samples were polymerase chain reaction-negative and strongly positive by serology. Interestingly, one-quarter of cases were likely to represent endogenous transmission of the infection. Conclusions Polymerase chain reaction is valuable in reliably diagnosing hepatitis E virus. However, serology is valuable for diagnosing resolved infection. There may be a high level of undiagnosed locally acquired hepatitis E virus in Scotland.
Identification of a cellular ligand for the natural cytotoxicity receptor NKp44
Authors: Baychelier Florence , Sennepin Alexis , Ermonval Myriam , Dorgham Karim , Debré Patrice , Vieillard Vincent 
Published: August 2013

Key Points
The cellular ligand of the NKp44L is a novel isoform of the mixed-lineage leukemia-5 protein. NKp44L is not expressed on healthy cells, but on tumor and transformed cells, rendering them more sensitive for the NK cytotoxicity.
De novo transcriptome assembly of drought tolerant CAM plants, Agave deserti and Agave tequilana
Authors: Gross Stephen M , Martin Jeffrey A , Simpson June , Abraham-Juarez María Jazmín , Wang Zhong , Visel Axel 
Published: August 2013

AbstractBackgroundAgaves are succulent monocotyledonous plants native to xeric environments of North America. Because of their adaptations to their environment, including crassulacean acid metabolism (CAM, a water-efficient form of photosynthesis), and existing technologies for ethanol production, agaves have gained attention both as potential lignocellulosic bioenergy feedstocks and models for exploring plant responses to abiotic stress. However, the lack of comprehensiveAgavesequence datasets limits the scope of investigations into the molecular-genetic basis ofAgavetraits.ResultsHere, we present comprehensive, high qualityde novotranscriptome assemblies of twoAgavespecies,A. tequilanaandA. deserti,built from short-read RNA-seq data. Our analyses support completeness and accuracy of thede novotranscriptome assemblies, with each species having a minimum of approximately 35,000 protein-coding genes. Comparison of agave proteomes to those of additional plant species identifies biological functions of gene families displaying sequence divergence in agave species. Additionally, a focus on the transcriptomics of theA. desertijuvenile leaf confirms evolutionary conservation of monocotyledonous leaf physiology and development along the proximal-distal axis.ConclusionsOur work presents a comprehensive transcriptome resource for twoAgavespecies and provides insight into their biology and physiology. These resources are a foundation for further investigation of agave biology and their improvement for bioenergy development.
The root transcriptome for North American ginseng assembled and profiled across seasonal development
Authors: Wu Di , Austin Ryan S , Zhou Sijun , Brown Dan 
Published: August 2013

Abstract

Background
Ginseng including North American ginseng (Panax quinquefolius L.) is one of the most widely used medicinal plants. Its success is thought to be due to a diverse collection of ginsenosides that serve as its major bioactive compounds. However, few genomic resources exist and the details concerning its various biosynthetic pathways remain poorly understood. As the root is the primary tissue harvested commercially for ginsenosides, next generation sequencing was applied to the characterization and assembly of the root transcriptome throughout seasonal development. Transcripts showing homology to ginsenoside biosynthesis enzymes were profiled in greater detail.

Results
RNA extracts from root samples from seven development stages of North American ginseng were subjected to 454 sequencing, filtered for quality and used in the de novo assembly of a collective root reference transcriptome consisting of 41,623 transcripts. Annotation efforts using a number of public databases resulted in detailed annotation information for 34,801 (84%) transcripts. In addition, 3,955 genes were assigned to metabolic pathways using the Kyoto Encyclopedia of Genes and Genomes. Among our results, we found all of the known enzymes involved in the ginsenoside backbone biosynthesis and used co-expression analysis to identify a number of candidate sequences involved in the latter stages ginsenoside biosynthesis pathway. Transcript profiles suggest ginsenoside biosynthesis occurs at distinct stages of development.

Conclusions
The assembly generated provides a comprehensive annotated reference for future transcriptomic study of North American ginseng. A collection of putative ginsenoside biosynthesis genes were identified and candidate genes predicted from the lesser understood downstream stages of biosynthesis. Transcript expression profiles across seasonal development suggest a primary dammarane-type ginsenoside biosynthesis occurs just prior to plant senescence, with secondary ginsenoside production occurring throughout development. Data from the study provide a valuable resource for conducting future ginsenoside biosynthesis research in this important medicinal plant.
Visit complexity, diagnostic uncertainty, and antibiotic prescribing for acute cough in primary care: a retrospective study
Authors: Whaley Lauren E , Businger Alexandra C , Dempsey Patrick P , Linder Jeffrey A 
Published: August 2013

Abstract

Background
Guidelines and performance measures recommend avoiding antibiotics for acute cough/acute bronchitis and presume visits are straightforward with simple diagnostic decision-making. We evaluated clinician-assigned diagnoses, diagnostic uncertainty, and antibiotic prescribing for acute cough visits in primary care.

Methods
We conducted a retrospective analysis of acute cough visits – cough lasting ≤21 days in adults 18–64 years old without chronic lung disease – in a primary care practice from March 2011 through June 2012.

Results
Of 56,301 visits, 962 (2%) were for acute cough. Clinicians diagnosed patients with 1, 2, or ≥ 3 cough-related diagnoses in 54%, 35%, and 11% of visits, respectively. The most common principal diagnoses were upper respiratory infection (46%), sinusitis (10%), acute bronchitis (9%), and pneumonia (8%). Clinicians prescribed antibiotics in 22% of all visits: 65% of visits with antibiotic-appropriate diagnoses and 4% of visits with non-antibiotic-appropriate diagnoses. Clinicians expressed diagnostic uncertainty in 16% of all visits: 43% of visits with antibiotic-appropriate diagnoses and 5% of visits with non-antibiotic-appropriate diagnoses. Clinicians expressed uncertainty more often when prescribing antibiotics than when not prescribing antibiotics (30% vs. 12%; p < 0.001). As the number of visit diagnoses increased from 1 to 2 to ≥ 3, clinicians were more likely to express diagnostic uncertainty (5%, 25%, 40%, respectively; p < 0.001) and prescribe antibiotics (16%, 25%, 41%, respectively; p < 0.001).

Conclusions
Acute cough may be more complex and have more diagnostic uncertainty than guidelines and performance measures presume. Efforts to reduce antibiotic prescribing for acute cough should address diagnostic complexity and uncertainty that clinicians face.