bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers
Authors: Bougeard Gaëlle , Renaux-Petel Mariette , Flaman Jean-Michel , Charbonnier Camille , Fermey Pierre , Belotti Muriel , Gauthier-Villars Marion , Stoppa-Lyonnet Dominique , Consolino Emilie , Brugières Laurence , Caron Olivier , Benusiglio Patrick R. , Bressac-de Paillerets Brigitte , Bonadona Valérie , Bonaïti-Pellié Catherine , Tinat Julie , Baert-Desurmont Stéphanie , Frebourg Thierry 
Published: May 2015

Purpose The aim of the study was to update the description of Li-Fraumeni syndrome (LFS), a remarkable cancer predisposition characterized by extensive clinical heterogeneity. Patients and Methods From 1,730 French patients suggestive of LFS, we identified 415 mutation carriers in 214 families harboring 133 distinct TP53 alterations and updated their clinical presentation. Results The 322 affected carriers developed 552 tumors, and 43% had developed multiple malignancies. The mean age of first tumor onset was 24.9 years, 41% having developed a tumor by age 18. In childhood, the LFS tumor spectrum was characterized by osteosarcomas, adrenocortical carcinomas (ACC), CNS tumors, and soft tissue sarcomas (STS) observed in 30%, 27%, 26%, and 23% of the patients, respectively. In adults, the tumor distribution was characterized by the predominance of breast carcinomas observed in 79% of the females, and STS observed in 27% of the patients. The TP53 mutation detection rate in children presenting with ACC or choroid plexus carcinomas, and in females with breast cancer before age 31 years, without additional features indicative of LFS, was 45%, 42% and 6%, respectively. The mean age of tumor onset was statistically different (P < .05) between carriers harboring dominant-negative missense mutations (21.3 years) and those with all types of loss of function mutations (28.5 years) or genomic rearrangements (35.8 years). Affected children, except those with ACC, harbored mostly dominant-negative missense mutations. Conclusion The clinical gradient of the germline TP53 mutations, which should be validated by other studies, suggests that it might be appropriate to stratify the clinical management of LFS according to the class of the mutation.
Economic Evaluation of Bevacizumab for the First-Line Treatment of Newly Diagnosed Glioblastoma Multiforme
Authors: Kovic Bruno , Xie Feng 
Published: May 2015

PurposeThe Avastin in Glioblastoma trial has shown that patients newly diagnosed with glioblastoma multiforme (GBM) treated with bevacizumab plus radiotherapy and temozolomide versus radiotherapy and temozolomide alone showed improvement in progression-free survival, possibly leading to a new indication for first-line use of bevacizumab in GBM. The cost-utility of this new intervention remains unknown; therefore, we developed a Markov model estimating the incremental cost-utility ratio (ICUR) from a Canadian public payer perspective.MethodsWe incorporated trial data for state transitions and treatment effects from the Avastin in Glioblastoma trial, costs and resource use data from Canadian published studies and databases, and utility parameters from published literature. We addressed uncertainty through one-way deterministic and probabilistic sensitivity analyses, extended the model to lifetime horizon and by another arm to compare first-line versus second-line use of bevacizumab on progression, performed value of information analysis, and performed US costing sensitivity analysis.ResultsAdding bevacizumab to radiotherapy and temozolomide resulted in increases of 0.13 quality-adjusted life-years (QALYs) and $80,000 per patient over 2-year time horizon at the base case analysis. The ICUR was $607,966/QALY (95% CI, $305,000/QALY to $2,550,000/QALY), with 0% chance of being cost effective at the $100,000/QALY willingness-to-pay threshold and never going below $450,000/QALY in the one-way sensitivity analysis. The ICUR using the US costing data was $787,519/QALY. The lifetime ICUR was $439,764/QALY (95% CI, $235,000/QALY to $1,520,000/QALY), never going below $350,000/QALY in the sensitivity analysis. Second-line use of bevacizumab on progression is more effective and less expensive than its first-line use. Value of information analysis revealed that future research is unwarranted.ConclusionBevacizumab has only limited effectiveness and is therefore not likely to be cost effective in treating adult patients with newly diagnosed GBM.
Structures and Biological Activities of Novel Biselyngbyaside Analogs Isolated from the Marine Cyanobacterium Lyngbya sp.
Authors: Watanabe Ayane , Ohno Osamu , Morita Maho , Inuzuka Toshiyasu , Suenaga Kiyotake 
Published: May 2015

Abstract
Novel biselyngbyaside analogs, biselyngbyolide C (1) and biselyngbyasides E (2) and F (3), were isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The gross structures of 1–3 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. These compounds inhibited the growth of HeLa and HL60 cells. From the results of an MTT assay, the geometry of the trisubstituted olefin in the side chain and the lack of the sugar moiety were found to be important for the biological activity. In addition, 1 was found to exhibit ER stress- and apoptosis-inducing activities in HeLa cells.
File Sharing and Film Revenues: Estimates of Sales Displacement at the Box Office
Authors: McKenzie Jordi , Walls W. David 
Published: May 2015

Abstract
This study examines the impact of peer-to-peer (P2P) file sharing on the Australian theatrical film industry. Using a large data set of torrent downloads observed on three popular P2P networks, we find evidence of a sales displacement effect on box office revenues. However, although statistically significant, the economic significance of this displacement appears relatively small. To establish causality, we make use of the state-day-level panel data structure permitting the use of film fixed effects to help mitigate the endogeneity between film revenues and downloads. To further assist identification, we propose a downloading cost function that considers other states’ downloading activities as a proxy for the number of peers in the download swarm; the US DVD release date as a supply shock to P2P networks; and the substantial structural progression within the Australian internet service provision industry that occurred over the sample period. We observe that the release gap between the US and Australian markets is a key contributor to piracy early in a film’s theatrical life. This finding provides a partial explanation for the industry’s move towards coordinated worldwide releases.
A nth-order shear deformation theory for
composite laminates in cylindrical bending
Authors: Sayyad A. S. , Ghugal Y. M. 
Published: May 2015

Abstract
The present study investigates whether an nthorder
shear deformation theory is applicable for the composite
laminates in cylindrical bending. The theory satisfies
the traction free conditions at top and bottom surfaces
of the plate and does not require problem dependent
shear correction factor which is normally associated with
the first order shear deformation theory. The well-known
classical plate theory at (n = 1) and higher order shear
deformation theory of Reddy at (n = 3) are the perticular
cases of the present theory. The governing equations
of equilibrium and boundary conditions are obtained using
the principle of virtual work. A simply supported laminated
composite plate infinitely long in y-direction is considered
for the detail numerical study. A closed form solution
for simply supported boundary conditions is obtained
using Navier’s technique. The displacements and stresses
are obtained for different aspect ratios and modular ratios.
Humor perception in bilinguals: Is language more than a code?
Authors: Erdodi Laszlo , Lajiness-O'Neill Renee 
Published: May 2015

AbstractThree samples (English, Hungarian and bilingual speakers, N = 91) were asked to rate 32 jokes covering various topics. Funniness ratings revealed several between- and within-group differences. Hungarians perceived jokes with ethnic stereotypes to be funnier than did either bilingual or English speakers. Bilinguals with Hungarian dominance rated jokes presented in Hungarian higher than jokes presented in English. No such preference was observed in bilinguals with English dominance. The implications of the findings to multicultural research and clinical practice are discussed.
Characteristics of Job Burnout and Humor among Psychotherapists
Authors: Malinowski Alfred J. 
Published: May 2015

AbstractJob burnout is one factor that has led many individuals to be ineffective in their profession. Psychotherapists have been shown to be especially vulnerable to the effects of job burnout in their field of specialization. Because of this fact, coping strategies are needed to protect the psychological well-being of the therapist and the therapeutic process. Humor is one coping technique that has been used in dealing with job burnout in various professions, but humor has also been shown to be detrimental to psychological well-being. In this study, a total of 133 doctoral degreed psychotherapists responded to a survey to determine the relationship between different types of humor (affiliative humor, self-enhancing humor, aggressive humor, and self-defeating humor) and various characteristics of job burnout (emotional exhaustion, depersonalization, and lack of a sense of personal accomplishment). Regression results indicated that self-defeating humor contributed to the job burnout characteristics of emotional exhaustion and depersonalization, whereas self-enhancing humor contributed to a therapist's sense of personal accomplishment. The results seem to indicate that different types of humor may either buffer or contribute to job burnout depending on how humor is used.
Humor styles, optimism, and their relationships with distress among undergraduates in three Chinese cities
Authors: Cheung Chau-Kiu , Yue Xiao Dong 
Published: May 2015

AbstractThe supposed benefit of humor for the relief of distress has not been demonstrated with certainty amongst Chinese people. In particular, an empirical study of this benefit is necessary in order to clarify the differential effects of different styles of humor, after controlling for optimism. With this aim, the present study investigates the effects based on data from 493 university students in three Chinese cities, Guangzhou, Hong Kong, and Macau. Results reveal some negative and positive effects of different humor styles on distress, independently of effects due to optimism. These effects did not vary among the three cities. Nevertheless, some limitations of the effects of humor are notable.
The role of social context in the interpretation of sexist humor
Authors: Gray Jared Alan , Ford Thomas E. 
Published: May 2015

AbstractAn experiment supported our hypotheses about the relationship between the social context in which sexist humor is delivered and the adoption of a non-critical humor mindset to interpret it. First, a professional workplace setting implied a local norm that is more prohibitive of sexist jokes than the general societal norm, whereas a comedy club implied a local norm of greater approval of sexist jokes. Second, offensiveness ratings revealed that participants were less likely to adopt a non-critical humor mindset to interpret sexist jokes delivered in a professional workplace setting and more likely to do so in a comedy club setting, compared to a setting governed by only the general societal norm. Finally, meditational analyses revealed that participants used the local norm of acceptability of sexist jokes to determine whether they could interpret the jokes in a non-critical humor mindset.
From Ice Age to Madagascar: Appreciation of slapstick humor in children with Asperger's syndrome
Authors: Weiss Elisabeth M. , Gschaidbauer Bianca C. , Samson Andrea C. , Steinbäcker Krista , Fink Andreas , Papousek Ilona 
Published: May 2015

AbstractThe aim of the present study was to examine whether children with Asperger's syndrome differ from typically developing children in the appreciation of and behavioral responses to simple slapstick type humor, in which cognitive requirements that are commonly impaired in autism spectrum disorders are reduced to a minimum. Short slapstick scenes and matched non-humorous control scenes were extracted from popular movies to produce an appropriate humor assessment material. Twenty-four boys with Asperger's syndrome (5 to 14 years) and 24 age-matched typically developed controls were tested. The results indicated that children with Asperger's syndrome enjoy humorous material as much as healthy children do, if the humor elements are simple and the incongruence can be perceived independently from theory of mind requirements, inferential demands, or language abilities. However, similar funniness ratings and behavioral expressions of mirth to the humorous scenes, but relatively higher values in response to the non-humorous scenes, suggested that the autistic children did not discriminate non-humorous from humorous stimuli as sensitively as the typically developing children did. Moreover, in autistic children, the outwards displays of emotion did not match their reports of subjective amusement. This dissociation may relate to the social interaction and communication difficulties in autism spectrum disorders.
Autism-spectrum traits predict humor styles in the general population
Authors: Eriksson Kimmo 
Published: May 2015

AbstractPrevious research shows that individuals with Asperger syndrome or high-functioning autism tend to have impaired processing of humor and laugh at things that are not commonly found funny. Here the relationship between humor styles and the broader autism phenotype was investigated in a sample of the general population. The autism-spectrum quotient (AQ) and the humor styles questionnaire (HSQ) were administered to six hundred US participants recruited through an Internet-based service. On the whole, high scores on AQ were negatively related to positive humor styles and unrelated to negative humor styles. However, AQ subscales representing different autism-spectrum traits exhibited different patterns. In particular, the factor “poor mind-reading” was associated with higher scores on negative humor styles and the factor “attention to detail” was associated with higher scores on all humor styles, suggesting a more nuanced picture of the relationship between autism-spectrum traits and humor.
Modeling Study of Crude Oil Enhanced Removal in a Two-Liquid Phase Partitioning Bioreactor
Authors: Ismail Zainab Z. , Abdulrazzak Ibtihaj A. 
Published: May 2015

AbstractA combined process of solvent extraction and two-phase biodegradation was carried out to remove crude oil from water by mixed cultures, where silicone oil was selected as the organic solvent due to its biocompatibility and non-biodegradability. The crude oil removal and cell growth was experimentally studied. A simple model that combined steady mass transfer equations and dynamic growth kinetics of suspended cells was suggested to follow the entire process. Under the conditions studied, complete removal of crude oil from water was achieved at initial crude oil concentration of 5,000 mg/L. Results revealed that the proposed model satisfactorily described the process as long as crude oil level in the cell medium did not exceed the toxicity limit of suspended cells.
Application Of Artificial Intelligence Methods In Drilling System Design And Operations: A Review Of The State Of The Art
Authors: Bello Opeyemi , Holzmann Javier , Yaqoob Tanveer , Teodoriu Catalin 
Published: May 2015

Abstract
Artificial Intelligence (AI) can be defined as the application of science and engineering with the intent of intelligent machine composition. It involves using tool based on intelligent behavior of humans in solving complex issues, designed in a way to make computers execute tasks that were earlier thought of human intelligence involvement. In comparison to other computational automations, AI facilitates and enables time reduction based on personnel needs and most importantly, the operational expenses.
Artificial Intelligence (AI) is an area of great interest and significance in petroleum exploration and production. Over the years, it has made an impact in the industry, and the application has continued to grow within the oil and gas industry. The application in E & P industry has more than 16 years of history with first application dated 1989, for well log interpretation; drill bit diagnosis using neural networks and intelligent reservoir simulator interface. It has been propounded in solving many problems in the oil and gas industry which includes, seismic pattern recognition, reservoir characterisation, permeability and porosity prediction, prediction of PVT properties, drill bits diagnosis, estimating pressure drop in pipes and wells, optimization of well production, well performance, portfolio management and general decision making operations and many more.
This paper reviews and analyzes the successful application of artificial intelligence techniques as related to one of the major aspects of the oil and gas industry, drilling capturing the level of application and trend in the industry. A summary of various papers and reports associated with artificial intelligence applications and it limitations will be highlighted. This analysis is expected to contribute to further development of this technique and also determine the neglected areas in the field.
Emerging heterogeneous integrated photonic platforms on silicon
Authors: Fathpour Sasan 
Published: May 2015

AbstractSilicon photonics has been established as a mature and promising technology for
optoelectronic integrated circuits, mostly based on the silicon-on-insulator
(SOI) waveguide platform. However, not all optical functionalities can be
satisfactorily achieved merely based on silicon, in general, and on the SOI
platform, in particular. Long-known shortcomings of silicon-based integrated
photonics are optical absorption (in the telecommunication wavelengths) and
feasibility of electrically-injected lasers (at least at room temperature). More
recently, high two-photon and free-carrier absorptions required at high optical
intensities for third-order optical nonlinear effects, inherent lack of
second-order optical nonlinearity, low extinction ratio of modulators based on
the free-carrier plasma effect, and the loss of the buried oxide layer of the
SOI waveguides at mid-infrared wavelengths have been recognized as other
shortcomings. Accordingly, several novel waveguide platforms have been
developing to address these shortcomings of the SOI platform. Most of these
emerging platforms are based on heterogeneous integration of other material
systems on silicon substrates, and in some cases silicon is integrated on other
substrates. Germanium and its binary alloys with silicon, III–V compound
semiconductors, silicon nitride, tantalum pentoxide and other high-index
dielectric or glass materials, as well as lithium niobate are some of the
materials heterogeneously integrated on silicon substrates. The materials are
typically integrated by a variety of epitaxial growth, bonding, ion implantation
and slicing, etch back, spin-on-glass or other techniques. These wide range of
efforts are reviewed here holistically to stress that there is no pure silicon
or even group IV photonics per se. Rather, the future of the
field of integrated photonics appears to be one of heterogenization, where a
variety of different materials and waveguide platforms will be used for
different purposes with the common feature of integrating them on a single
substrate, most notably silicon.
Genetic Variations in the Serotonergic System Mediate a Combined, Weakened Response to SSRI Treatment: A Proposed Model
Authors: Pettitt Adam 
Published: May 2015

AbstractIndividuals with the short (S) allele in the promoter region of the serotonin transporter gene (5-HTTLPR) show a less favorable response to selective serotonin reuptake inhibitor (SSRI) treatment than individuals with the long (L) allele. Similarly, individuals with the C(-1019)G allele for the mutation found in the promoter region of the serotonin 1A receptor gene (5-HTR1A) have shown blunted responses to SSRI treatment when compared with individuals lacking this polymorphism. While these findings have been replicated across multiple studies, only two studies to date have reported data for a gene–gene interaction associated with response to SSRI treatment. Both of these studies reported a combined effect for these genotypes, with individuals homozygous for the L allele and the C allele (5-HTTL/L−1AC/C) reporting the most favorable response to SSRI treatment, and individuals homozygous for the S allele and the G allele (5-HTTS/S–1AG/G) reporting the least favorable response to SSRI treatment. Additionally, no neural mechanisms have been proposed to explain why this gene–gene interaction has been observed. To that end, this article provides a review of the relevant literature associated with these polymorphisms and proposes a feasible model that describes a genotype-dependent modulation of postsynaptic serotonin signaling associated with the 5-HTT and 5-HTR1A genes.
Prevalence and risk factors of gestational diabetes in Punjab, North India: results from a population screening program
Authors: Arora Geeti P , Thaman Richa G , Prasad Rashmi B , Almgren Peter , Brøns Charlotte , Groop Leif C , Vaag Allan A 
Published: May 2015

ObjectiveThe World Health Organization (WHO) has in 2013 changed the diagnostic criteria for gestational diabetes mellitus (GDM) to acknowledge the putative effect of mildly elevated fasting plasma glucose (FPG) levels on pregnancy outcomes. We aimed to determine the prevalence and risk factors of GDM comparing the previous WHO 1999 criteria to the WHO 2013 criteria in North India.MethodsIn a population-based screening programme, 5100 randomly selected North Indian women were studied using a cross-sectional design with a questionnaire, venous FPG and 2-h capillary plasma glucose (PG) after a 75 g oral glucose tolerance test performed between 24 and 28 weeks of pregnancy.ResultsThe prevalence of GDM was 35% using WHO 2013 criteria vs 9% using WHO 1999 criteria. FPG measurements identified 94% of WHO 2013 GDM cases as opposed to 11% of WHO 1999 GDM cases. In contrast, 2-h PG measurements identified only 13% of WHO 2013 GDM cases compared with 96% of the WHO 1999 GDM cases. Using logistic regression with backward elimination, urban habitat, illiteracy, non-vegetarianism, increased BMI, Hindu religion and low adult height were all independent risk factors of GDM using the 1999 criteria, whereas only urban habitat, low adult height and increased age were independent risk factors of GDM using the 2013 criteria.ConclusionsIntervention studies are needed to justify the WHO 2013 GDM criteria increasing the prevalence four fold to include more than one third of North Indian pregnant women.