bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palaeozoic high-Ti basalt, an indicator for incipient rifting, at the Saxo-Thuringian passive margin, NE-Bavaria (Germany)
Authors: Lucassen Friedrich , Franz Gerhard , Kutzschbach Martin , Schiperski Ferry 
Published: February 2025

Abstract
We investigated mafic igneous rocks found in the vicinity of the allochthonous Münchberg Massif in the Saxo-Thuringian Zone of the European Variscides, NE Bavaria. The basaltic magmas were injected during the Ordovician, Silurian and Devonian into contemporaneous marine sedimentary rocks of the Saxo-Thuringian Basin. Ordovician sills east and Devonian volcanic to subvolcanic rocks west of the Münchberg Massif show high Fe and Ti contents that place them in the rarely occurring group of high Fe–Ti basalts with FeO content of up to 17.6 wt% and up to 5.7 wt% TiO2. Covariation of Nb, Y and Zr with major elements indicates compositional control by fractionation. Trace element patterns are similar to those of ocean island basalt and continental intraplate magmatic rocks. Nd isotope signatures of the mafic rocks from the Early Palaeozoic until the Devonian resemble those of the regional continental lithospheric mantle of the Saxo-Thuringian and Bohemian zones. Their Sr isotope signatures show the variable influence of post-magmatic mobilisation. The major source of these mafic rocks is likely the subcontinental lithospheric mantle. The Pb isotope compositions of the mafic rocks do not allow distinguishing between mantle and crustal sources but resemble the regional crustal signatures. Crustal contamination in the mafic rocks is minor. The geochemical signatures of the mafic igneous rocks and continuous deposition of their host sediments indicate a long-standing passive margin setting between the northern part of Gondwana and the Saxo-Thuringian. In contrast, the trace element patterns and isotope characteristics of post-Devonian mafic dykes in the allochthonous Münchberg Massif are significantly different: They are related to a late stage of subduction during the Variscan orogeny.

Graphical abstract
The effect of music interventions compared to standard-of-care on the prevention of delirium in neurosurgical patients: an analysis of costs and cost-effectiveness based on the MUSYC-trial
Authors: Dirven Thomas L.A. , Kappen Pablo R. , van der Beek Frederike Ten Harmsen , van der Holt Bronno , Jeekel Hans , Dirven Clemens M.F. , Vincent Arnaud J.P.E. , Klimek Markus , Poley Marten J. 
Published: February 2025

Abstract

Background
Postoperative delirium is a frequent complication with negative consequences for neurosurgical patients. Recorded music has been shown to reduce the incidence of delirium, however its economic benefit remains unclear. This study aimed to investigate the cost-effectiveness of perioperative music in preventing postoperative delirium.

Methods
This study used data from a randomized controlled trial (Clinical Trials.gov; NCT04649450) that compared the effect of perioperative music with standard of clinical care on the occurrence of postoperative delirium in patients undergoing craniotomy at the Erasmus Medical Centre. The primary outcome of this study is the cost-effectiveness of the music intervention. A trial-based cost-effectiveness analysis (CEA) was conducted from a societal perspective. Mean costs were calculated using bootstrapping with 95% confidence intervals. Secondary outcomes included postoperative complications, mortality, cognitive functioning, and quality of life. Costs and patient outcomes were assessed separately for the initial hospital admission and long-term follow-up until 6 months after discharge.

Results
This study included 91 patients in the intervention group and 93 in the control group. On average, medical costs during initial admission were lower, albeit not statistically significant, in the music group compared to the control group (€ 11,819 vs. € 13,106), mostly due to a shorter length of stay. Total costs over the 6-month period were nearly identical between the groups, at € 18,587 and € 18,571 in the music and control group, respectively.

Conclusions
Pre-recorded perioperative music may be a cost-effective intervention for reducing postoperative delirium in neurosurgical patients, possibly by decreasing healthcare utilization and costs during primary admission. Further studies are needed to confirm its potential as a cost-effective intervention.
Analysing the future trends of foehn-enabling synoptic patterns over two valleys in the Eastern Alps in CMIP5 EURO-CORDEX models
Authors: Maier Philipp , Klisho Tatiana , Formayer Herbert , Lehner Fabian 
Published: February 2025

Abstract
Foehn has an impact on various climatological variables like temperature and humidity in the highly populated valleys of the Eastern Alps. With increasing global warming, the question arises as to how well climate projections are able to produce conditions for foehn and how their occurrence changes with climate change. This study uses four XGBoost models to classify foehn in EURO-CORDEX climate models of the CMIP5 generation for localised and widespread foehn events in Rhine and Inn valley located in the Eastern Alps, whereas ERA5 reanalysis data in combination with training data derived from semi-automated weather stations are used in the training process. Weights for individual models are derived by analysing the performance of EURO-CORDEX models in their ability to produce foehn-enabling conditions and considering their independence from each other in the historical period. Bias analysis shows a systematic negative bias in annual foehn occurrence for the GCMs ICHEC-EC-EARTH and MOHC-HadGEM2-ES, whereas others show no systematic bias. The training data confirm other studies by showing that the two selected valleys show differences in foehn occurrence and in the portion of widespread events. A weighted trend analysis for future behaviour of foehn shows a statistically significant increase in widespread events in Rhine valley and a decrease in total events in Inn valley under increasing warming conditions. Further, a shift in foehn seasonality in both valleys can be observed with a higher frequency in the spring months and a lower frequency from July to October, also depending on the climate change signal.
High and low-frequency climate modes associated with sub-seasonal sea surface temperature variability in the Gulf of Guinea
Authors: Ibebuchi Chibuike Chiedozie , Obarein Omon A. 
Published: February 2025

Abstract
Sea Surface Temperature (SST) variability in the Gulf of Guinea (GoG) significantly influences the regional climate of West Africa and the marine ecosystem of the Atlantic Ocean. This study examines both high-frequency (seasonal to sub-seasonal) and low-frequency (interannual to interdecadal) climatic modes contributing to SST variability in the GoG. Findings indicate that the El Niño Southern Oscillation is associated with SST variability in the GoG. Nonetheless, the Tropical South Atlantic Ocean’s SST patterns are the primary driver of the GoG’s seasonal to sub-seasonal SST variability. We identified high-frequency SST modes in the South Atlantic Ocean using an autoencoder artificial neural network applied to high-pass filtered monthly SST data. The extreme gradient boosting feature importance metric revealed that the different high-frequency SST modes including localized anomaly off the west coast of northern Namibia; SST anomaly in the Atlantic Niño region; widespread anomaly in the subtropical South Atlantic, and a dipole anomaly off the southeast coast of South America and the GoG emerged as the most effective predictors of average SST in the GoG, achieving a correlation of 0.89 and explaining 78% of the variance with a one-month lead time forecast. Concerning the low-frequency modes, our findings show that while the Tropical South Atlantic mode and the South Atlantic Ocean dipole mode predominantly correlate with sub-seasonal SST in the GoG, other tropical and high-latitude modes also significantly influence SST variability in the GoG. Finally, we presented a novel framework for accurate sub-seasonal SST prediction in the GoG using machine learning and further identified low and high-frequency modes that can provide sub-seasonal to inter-decadal predictability of SST in the GoG.
Viscoelastic Kirchhoff–Love shells at finite strains: constitutive modeling and mixed low-regularity finite elements
Authors: Platzer Sebastian , Pechstein Astrid , Humer Alexander , Krommer Michael 
Published: February 2025

Abstract
The finite element simulation of thin viscoelastic membranes is a challenging problem. On the one hand, geometric dimensions of the membrane are adverse to classical finite element formulations, which require the thickness of the structure to be resolved. On the other hand, both material and geometric nonlinearities need to be considered in the large-strain regime. In the present paper, a Kirchhoff–Love shell formulation including thickness deformation is deduced for incompressible viscoelastic membranes at finite strain. For this formulation, a mixed shell element with low regularity is proposed to discretize a viscoelastic shell formulation based on a multiplicative split of the deformation gradient. The formulation is tested against full three-dimensional formulations in a variety of examples. Excellent accordance of results in quasi-static as well as dynamic simulations is observed.
Model-Based prediction of linearized stiffness and damping values for bolted joints
Authors: Dalkiz Rasim , Jacobs Georg , Höpfner Gregor , Wischmann Stefan 
Published: February 2025

Abstract
The virtual testing of a technical product in terms of its acoustic behavior enables the engineer to evaluate the design without the need for physical prototypes. To predict the acoustic behavior virtually, models should consider both the dynamic excitations of the system and the transfer behavior of sound from the excitation source to the user. The transfer behavior is influenced by the resonance frequencies and the damping of the structure, the latter of which mainly occurs in the joints between the components. Stiffness and damping values are required to design the transfer behavior of the joints. For this, load conditions must be determined. To model load and displacement states occurring in the joint in dynamic applications, a distributed approach can be used by modelling in the FEM. This makes it possible to consider the influence of the microgeometry in the form of the surface roughness on the transfer behavior of the joint. To use the continuously distributed load and displacement states in concentrated model elements or as design parameters in the form of linearized stiffness and damping values, the load conditions must be linearized in the considered operating point. This paper therefore presents a method for the model-based derivation of linearized stiffness and damping values, which assesses the influence of the design of the joint on stiffness and damping on the basis of experimentally determined surface roughness. For this, distributed models in the FE are parameterized based on a measured surface roughnesses. Based on these models, linearized stiffness and damping values are determined for different joint geometries. This makes it possible for the first time to derive model-based linearized stiffness and damping values for different joint geometries. The Brake-Reuss beam is used as an academic object of investigation. Transferring the method to industrial systems can optimize costs and resources in the product development process.
Epidemiology and risk factors of expatriates returning to Switzerland colonized at the intestinal level with multidrug-resistant Enterobacterales
Authors: Campos-Madueno Edgar I. , Aldeia Claudia , Roumet Marie C. , Limacher Andreas , Sendi Parham , Endimiani Andrea 
Published: February 2025

Abstract
Living in high-endemic regions increases the risk of intestinal colonization by multidrug-resistant Enterobacterales (MDR-Ent). This study investigated Swiss expatriates residing abroad (≥ 3 months) to assess their colonization status upon returning to Switzerland. Selective culture-based methods were implemented to detect third-generation cephalosporins- (3GC-R), carbapenems- (CR), and colistin-resistant (COL-R) strains. Whole-genome sequencing was used to characterize antimicrobial resistance genes, sequence type (ST), and phylogroup of MDR-Ent. Epidemiological data were analyzed using uni- and multivariable models to identify risk factors, providing crude and adjusted odds ratios (ORs). Among 196 participants living across Africa, Asia, the Americas, and Europe, the overall MDR-Ent colonization prevalence was 42.9%. Continent of residence emerged as a significant risk factor (p = 0.04) for colonization: Africa (adjusted OR = 3.4, 95% CI 1.0–11.0) and Asia (adjusted OR = 4.7, 95% CI 1.5–15.0). Extended-spectrum β-lactamase-producing Escherichia coli (Ec) was the most frequent isolated species (n = 107 out of 119 Ent). Most 3GC-R-Ec possessed bla
CTX−M genes (n = 89; 83.2%) and pandemic lineages were frequent (e.g., ST69 and ST131, n = 18). No CR-Ent were detected, but some COL-R strains (n = 18; of which 15 Ec) harbored the mcr-1.1 gene. Expatriates represent an understudied population at risk of MDR-Ent colonization. This population may contribute to the importation and potential dissemination of dangerous bacteria into low-prevalence countries, as shown in this Swiss study, warranting further investigation and surveillance.
Characteristics of patients with metastatic renal cell carcinoma who do not respond to axitinib treatment
Authors: Ohba Kojiro , Osawa Takahiro , Kojima Takahiro , Hara Tomohiko , Sugimoto Mikio , Eto Masatoshi , Minami Keita , Nakai Yasutomo , Ueda Kosuke , Naito Sei , Nonomura Norio , Murai Sachiyo , Nishiyama Hiroyuki , Nakanishi Hiromi , Mukae Yuta , Mitsunari Kensuke , Matsuo Tomohiro , Imamura Ryoichi , Shinohara Nobuo 
Published: February 2025

Abstract

Background
Axitinib is a widely used tyrosine kinase inhibitor (TKI) in metastatic renal cell carcinoma (mRCC) treatment. Here, we analyzed the characteristics of patients who did not respond to axitinib and evaluated alternative options for their treatment.

Methods
We retrospectively analyzed data for 449 patients with mRCC who were administered axitinib following another TKI as initial therapy. Patients with progressive disease (PD) at their first assessment were defined as showing early-PD. We analyzed the characteristics of patients at risk of early-PD and evaluated the relationship between the treatment following axitinib and their prognosis.

Results
Early-PD was diagnosed in 102 patients, and was more common in those who had not undergone nephrectomy (p < 0.001), those treated with a TKI for a short period (p < 0.001), and those in the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) poor risk category for mRCC (p < 0.001). Multivariate analysis showed that these were independent risk factors for early-PD (all p < 0.001). Of those with early-PD, 52 changed to next-line treatment. The progression-free survival periods were 5.5 (95% confidence interval (CI) 2.4–8.6) months for patients administered TKIs, 4.2 (95% CI 0.3–8.1) months for those on nivolumab, and 2.2 (1.8–2.6) months for those on mammalian target of rapamycin inhibitors (p = 0.030).

Conclusion
Patients who have not undergone nephrectomy, those previously treated with another TKI for a short period, and those in the IMDC poor risk category are more likely to experience early-PD when taking axitinib. Furthermore, TKIs are the best treatment for patients with early-PD who have previously been administered axitinib.
DECODE-3DViz: Efficient WebGL-Based High-Fidelity Visualization of Large-Scale Images using Level of Detail and Data Chunk Streaming
Authors: AboArab Mohammed A. , Potsika Vassiliki T. , Skalski Andrzej , Stanuch Maciej , Gkois George , Koncar Igor , Matejevic David , Theodorou Alexis , Vagena Sylvia , Sigala Fragiska , Fotiadis Dimitrios I. 
Published: February 2025

Abstract
The DECODE-3DViz pipeline represents a major advancement in the web-based visualization of large-scale medical imaging data, particularly for peripheral artery computed tomography images. This research addresses the critical challenges of rendering high-resolution volumetric datasets via WebGL technology. By integrating progressive chunk streaming and level of detail (LOD) algorithms, DECODE-3DViz optimizes the rendering process for real-time interaction and high-fidelity visualization. The system efficiently manages WebGL texture size constraints and browser memory limitations, ensuring smooth performance even with extensive datasets. A comparative evaluation against state-of-the-art visualization tools demonstrates DECODE-3DViz's superior performance, achieving up to a 98% reduction in rendering time compared with that of competitors and maintaining a high frame rate of up to 144 FPS. Furthermore, the system exhibits exceptional GPU memory efficiency, utilizing as little as 2.6 MB on desktops, which is significantly less than the over 100 MB required by other tools. User feedback, collected through a comprehensive questionnaire, revealed high satisfaction with the tool's performance, particularly in areas such as structure definition and diagnostic capability, with an average score of 4.3 out of 5. These enhancements enable detailed and accurate visualizations of the peripheral vasculature, improving diagnostic accuracy and supporting better clinical outcomes. The DECODE-3DViz tool is open source and can be accessed at https://github.com/mohammed-abo-arab/3D_WebGL_VolumeRendering.git.
Maternal Factors Influencing the Nutritional Status of HIV-Exposed Infants: A 12-Month Follow-Up in Mathare and Kibera Informal Settlements in Nairobi County
Authors: Kiilu Elizabeth Mueke , Karanja Simon , Kikuvi Gideon , Muthoki Linet 
Published: February 2025

Abstract
Optimal infant nutrition is crucial for good health and survival. HIV-exposed infants have a greater incidence of low birthweight than HIV-unexposed infants, predisposing them to malnutrition and a greater risk of HIV infection. A 12-month longitudinal study was conducted on 166 HIV-exposed infants, assessing nutritional status at 6 weeks, 6 months, and 12 months. Fisher’s test and logistic regression analysed the data using WHO growth standards. Ethical approval was obtained (KEMRI/SERU/CPHR/002/3525). Results: Wasting: Younger maternal age (18–24 years) presented higher odds of infant wasting across all timepoints: 6 weeks aOR 4.31 (CI: 1.11, 1.83), 6 months aOR 4.49 (CI: 1.09, 27.34), and 12 months aOR 5.49 (CI: 1.41, 32.97). Stunting: At 6 months, infants of underweight mothers and those on second-line antiretroviral therapy (ART) regimens had higher odds of stunting aOR 4.76 (CI: 1.36, 16.65) and aOR 5.49 (CI: 1.64, 18.38), respectively. At 12 months, poor maternal ART adherence aOR 4.11 (CI: 1.14, 14.82) and mothers on second-line ART regimens aOR 3.68 (CI: 1.09, 12.49) had increased odds of infant stunting. Underweight: At 6 weeks, high maternal viral load aOR 6.33 (CI: 2.31, 17.36) was associated with higher odds underweight infants, whereas employed mothers had lower odds of underweight infants at 6 and 12 months aOR 0.10 (CI: 0.03, 0.32) and aOR 0.22 (CI: 0.09, 0.59) respectively. The results highlight maternal nutrition and ART adherence’s influence on infant nutritional status and HIV vertical transmission risk. The study recommended integrating comprehensive nutritional care into HIV policies and enhancing ART counselling to reduce vertical transmission risk and poor infant growth.
Design, fabrication, and characterization of a user-friendly microfluidic device for studying liver zonation-on-chip (ZoC)
Authors: Mahdavi Reza , Hashemi-Najafabadi Sameereh , Ghiass Mohammad Adel , Valaskivi Silmu , Välimäki Hannu , Kreutzer Joose , Hamngren Blomqvist Charlotte , Romeo Stefano , Kallio Pasi , Adiels Caroline Beck 
Published: February 2025

Abstract
Liver zonation is a fundamental characteristic of hepatocyte spatial heterogeneity, which is challenging to recapitulate in traditional cell cultures. This study presents a novel microfluidic device designed to induce zonation in liver cell cultures by establishing an oxygen gradient using standard laboratory gases. The device consists of two layers; a bottom layer containing a gas channel network that delivers high (cell incubator air, 19% oxygen) and low oxygenated (nitrogen) gases to create three distinct zones within the cell culture chamber in the layer above. Computational simulations and ratiometric oxygen sensing were employed to validate the oxygen gradient, demonstrating that stable oxygen levels were achieved within two hours. Liver zonation was confirmed using immunofluorescence staining, which showed zonated albumin production in HepG2 cells directly correlating with oxygen levels and mimicking in-vivo zonation behavior. This user-friendly device supports studies on liver zonation and related metabolic disease mechanisms in vitro. It can also be utilized for experiments that necessitate precise gas concentration gradients, such as hypoxia-related research areas focused on angiogenesis and cancer development.
Effects of multilayered cellulose-based coatings on the barrier properties of paperboard
Authors: Lyytikäinen Johanna , Koljonen Krista , Leminen Ville 
Published: February 2025

Abstract
Coating a paperboard is the most important finishing process to achieve a good barrier against oxygen, water vapor and grease, which are typically obtained with fossil-based plastics. In this study, three different cellulose-based coating components—methyl nanocellulose (MeNC), microfibrillated cellulose (MFC) and hydrophobically modified ethyl(hydroxyethyl) cellulose (HM-EHEC)—were investigated. One to five coating layers were applied to the paperboard using spray and rod coating. Combinations of different coating components, coat weights, and barrier properties at different temperatures and relative humidities were studied. Scanning electron microscopy, air permeance and contact angle measurements using water and oil were used to characterize the uncoated and coated surfaces. It was shown that the MeNC and MFC layers increased the surface wettability. On contrary, HM-EHEC coating provided surface hydrophobicity, but reduced oil repellence. According to oxygen barrier measurements, HM-EHEC seemed to provide resistance at high humidities. In addition, a coating with a low weight could not close the surface completely and resulted in a poor grease barrier. However, high-weight coatings with MFC and HM-EHEC layers were greaseproof, even at elevated temperature and humidities.