bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between N‐Terminal Pro‐Brain Natriuretic Peptide Levels and Contrast‐Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
Authors: Kurtul Alparslan , Duran Mustafa , Yarlioglues Mikail , Murat Sani Namik , Demircelik Muhammed Bora , Ergun Gokhan , Acikgoz Sadik Kadri , Sensoy Baris , Cetin Mustafa , Ornek Ender 
Published: May 2014

AbstractBackgroundContrast‐induced nephropathy (CIN) is associated with significantly increased morbidity and mortality after percutaneous coronary intervention (PCI). Patients with acute coronary syndrome (ACS) are at higher risk for CIN. N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) is closely linked to the prognosis as a strong predictor of both short‐ and long‐term mortality in patients with ACS.HypothesisWe hypothesized that NT‐proBNP levels on admission can predict the development of CIN after PCI for ACS.MethodsA total of 436 patients (age 62.27 ± 13.01 years; 64.2% male) with ACS undergoing PCI enrolled in this study. Admission NT‐proBNP levels were measured before PCI. Serum creatinine values were measured before and within 72 hours after the administration of contrast agents. Patients were divided into 2 groups: CIN group and no‐CIN group. CIN was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 hours after contrast administration.ResultsCIN developed in 63 patients (14.4%). Baseline NT‐proBNP levels were significantly higher in patients who developed CIN compared to those who did not develop CIN (median 774 pg/mL, interquartile range 177.4–2184 vs median 5159 pg/mL, interquartile range 2282–9677, respectively; P < 0.001). Multivariate analysis found that NT‐proBNP (odds ratio [OR]: 3.448, 95% confidence interval [CI]: 1.394‐8.474, P = 0.007) and baseline creatinine (OR: 6.052, 95% CI: 1.860‐19.686, P = 0.003) were independent predictors of CIN.ConclusionsAdmission NT‐proBNP level is an independent predictor of the development of CIN after PCI in ACS.
Antibacterial, Antifungal, Phytotoxic, and Genotoxic Properties of Two Complexes of AgI with Sulfachloropyridazine (SCP): X‐ray Diffraction of [Ag(SCP)]n
Authors: Mosconi Natalia , Giulidori Cecilia , Velluti Francesca , Hure Estela , Postigo Agustina , Borthagaray Graciela , Back Davi Fernando , Torre María H. , Rizzotto Marcela 
Published: May 2014

AbstractWe report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN− ligands (Ag–SCP–SCN), the other of which is homoleptic (Ag–SCP); furthermore, the crystal structure of the homoleptic complex is disclosed. The heterocyclic N atom nearest to the Cl atom and the Nsulfonamide atom could be coordination sites for the silver ion in the Ag–SCP–SCN complex. The Ag–SCP complex is a polymeric compound with metal–metal bonds, and the heterocyclic and sulfonamide N atoms are points of coordination for AgI. Both complexes showed activity against all the tested bacteria, and in the cases of Escherichia coli and Pseudomonas aeruginosa, the action was better than that of SCP. In all cases, both silver–SCP complexes showed better antifungal activity than SCP, which was inactive against the tested fungi. Notably, the activity against P. aeruginosa, a nosocomial multidrug‐resistant pathogen, was better than that of the reference antibiotic cefotaxim. Both silver–sulfa complexes displayed moderate activity against the tested yeast, especially for C. neoformans, which is an important fact considering the incidence of cryptococcosis, mainly in immune‐deficient patients. No chromosomal aberrations were observed with the Allium cepa test, which is auspicious for further study of these complexes as potential drugs.
Daughters and Mothers Against Breast Cancer (DAMES): Main outcomes of a randomized controlled trial of weight loss in overweight mothers with breast cancer and their overweight daughters
Authors: Demark‐Wahnefried Wendy , Jones Lee W. , Snyder Denise C. , Sloane Richard J. , Kimmick Gretchen G. , Hughes Daniel C. , Badr Hoda J. , Miller Paige E. , Burke Lora E. , Lipkus Isaac M. 
Published: May 2014

BACKGROUNDFew studies to date have used the cancer diagnosis as a teachable moment to promote healthy behavior changes in survivors of cancer and their family members. Given the role of obesity in the primary and tertiary prevention of breast cancer, the authors explored the feasibility of a mother‐daughter weight loss intervention.METHODSA randomized controlled trial of a mailed weight loss intervention was undertaken among 68 mother‐daughter dyads (n = 136), each comprised of a survivor of breast cancer (AJCC stage 0‐III) and her adult biological daughter. All women had body mass indices ≥ 25 kg/m2 and underwent in‐person assessments at baseline, 6 months, and 12 months, with accelerometry and exercise capacity performed on a subset of individuals. All women received a personalized workbook and 6 newsletters over a 1‐year period that promoted weight loss; exercise; and a nutrient‐rich, low‐energy density diet. A total of 25 dyads received individually tailored instruction (INDIVIDUAL), 25 dyads received team‐tailored instruction (TEAM), and 18 dyads received standardized brochures (CONTROL).RESULTSThe trial met its accrual target, experienced 90% retention, and caused no serious adverse events. Significant differences in baseline to 12‐month changes were observed between INDIVIDUAL versus CONTROL mothers for body mass index, weight, and waist circumference (WC); significant differences also were observed in the WC of corresponding daughters (P < .05). Significant differences were found between INDIVIDUAL versus CONTROL and TEAM versus CONTROL dyads for WC (P = .0002 and .018, respectively), minutes per week of physical activity (P = .031 and .036, respectively), and exercise capacity (P = .047 for both).CONCLUSIONSSignificant improvements in lifestyle behaviors and health outcomes are possible with tailored print interventions directed toward survivors of cancer and their family members. For greater impact, more research is needed to expand this work beyond the mother‐daughter dyad. Cancer 2014;120:2522–2534. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Extreme heterogeneity of myeloablative total body irradiation techniques in clinical practice: A survey of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
Authors: Giebel Sebastian , Miszczyk Leszek , Slosarek Krzysztof , Moukhtari Leila , Ciceri Fabio , Esteve Jordi , Gorin Norbert‐Claude , Labopin Myriam , Nagler Arnon , Schmid Christoph , Mohty Mohamad 
Published: May 2014

BACKGROUNDTotal body irradiation (TBI) is widely used for conditioning before hematopoietic cell transplantation. Its efficacy and toxicity may depend on many methodological aspects. The goal of the current study was to explore current clinical practice in this field.METHODSA questionnaire was sent to all centers collaborating in the European Group for Blood and Marrow Transplantation and included 19 questions regarding various aspects of TBI. A total of 56 centers from 23 countries responded.RESULTSAll centers differed with regard to at least 1 answer. The total maximum dose of TBI used for myeloablative transplantation ranged from 8 grays (Gy) to 14.4 Gy, whereas the dose per fraction was 1.65 Gy to 8 Gy. A total of 16 dose/fractionation modalities were identified. The dose rate ranged from 2.25 centigrays to 37.5 centigrays per minute. The treatment unit was linear accelerator (LINAC) (91%) or cobalt unit (9%). Beams (photons) used for LINAC were reported to range from 6 to 25 megavolts. The most frequent technique used for irradiation was “patient in 1 field,” in which 2 fields and 2 patient positions per fraction are used (64%). In 41% of centers, patients were immobilized during TBI. Approximately 93% of centers used in vivo dosimetry with accepted discrepancies between the planned and measured doses of 1.5% to 10%. In 84% of centers, the lungs were shielded during irradiation. The maximum accepted dose for the lungs was 6 Gy to 14.4 Gy.CONCLUSIONSTBI is an extremely heterogeneous treatment modality. The findings of the current study should warrant caution in the interpretation of clinical studies involving TBI. Further investigation is needed to evaluate how methodological differences influence outcome. Efforts to standardize the method should be considered. Cancer 2014;120:2760–2765. © 2014 American Cancer Society.
Efficient Solid Acid Catalyst Containing Lewis and Brønsted Acid Sites for the Production of Furfurals
Authors: Mazzotta Michael G. , Gupta Dinesh , Saha Basudeb , Patra Astam K. , Bhaumik Asim , Abu‐Omar Mahdi M. 
Published: May 2014

AbstractSelf‐assembled nanoparticulates of porous sulfonated carbonaceous TiO2 material that contain Brønsted and Lewis acidic sites were prepared by a one‐pot synthesis method. The material was characterized by XRD, FTIR spectroscopy, NH3 temperature‐programmed desorption, pyridine FTIR spectroscopy, field‐emission scanning electron microscopy, high‐resolution transmission electron microscopy, N2‐sorption, atomic absorbance spectroscopy, and inductively coupled plasma optical emission spectroscopy. The carbonaceous heterogeneous catalyst (Glu‐TsOH‐Ti) with a Brønsted‐to‐Lewis acid density ratio of 1.2 and more accessible acid sites was effective to produce 5‐hydroxymethylfurfural and furfural from biomass‐derived mono‐ and disaccharides and xylose in a biphasic solvent that comprised water and biorenewable methyltetrahydrofuran. The catalyst was recycled in four consecutive cycles with a total loss of only 3 % activity. Thus, Glu‐TsOH‐Ti, which contains isomerization and dehydration catalytic sites and is based on a cheap and biorenewable carbon support, is a sustainable catalyst for the production of furfurals, platform chemicals for biofuels and chemicals.
C‐reactive protein predicts mortality in patients referred for coronary angiography and symptoms of heart failure with preserved ejection fraction
Authors: Koller L. , Kleber M. , Goliasch G. , Sulzgruber P. , Scharnagl H. , Silbernagel G. , Grammer T. , Delgado G. , Tomaschitz A. , Pilz S. , März W. , Niessner A. 
Published: May 2014

AimsHeart failure with preserved ejection fraction (HFpEF) has a different pathophysiological background compared to heart failure with reduced ejection fraction (HFrEF). Tailored risk prediction in this separate heart failure group with a high mortality rate is of major importance. Inflammation may play an important role in the pathogenesis of HFpEF because of its significant contribution to myocardial fibrosis. We therefore aimed to assess the predictive value of C‐reactive protein (CRP) in patients with HFpEF.Methods and resultsPlasma levels of CRP were determined in 459 patients with HFpEF in the LUdwigshafen Risk and Cardiovascular Health (LURIC) study using a high‐sensitivity assay. During a median follow‐up of 9.7 years 40% of these patients died. CRP predicted all‐cause mortality with an adjusted hazard ratio (HR) of 1.20 [95% confidence interval (CI) 1.02–1.40, P = 0.018] and cardiovascular mortality with a HR of 1.32 (95% CI 1.08–1.62, P = 0.005) per increase of one standard deviation. CRP was a significantly stronger mortality predictor in HFpEF patients than in a control group of 522 HFrEF patients (for interaction, P = 0.015). Furthermore, CRP added prognostic value to N‐terminal pro B‐type natriuretic peptide (Nt‐proBNP): the lowest 5‐year mortality rate of 6.8% was observed for patients in the lowest tertile of Nt‐proBNP as well as CRP. The mortality risk peaked in the group combining the highest values of Nt‐proBNP and CRP with a 5‐year rate of 36.5%.ConclusionIt was found that CRP was an independent and strong predictor of mortality in HFpEF. This observation may reflect immunological processes with an adverse impact on the course of HFpEF.
Heart failure with preserved ejection fraction: the impact of stricter definitions
Authors: Patel Hitesh C. , Hayward Carl , di Mario Carlo , Cowie Martin R. , Lyon Alexander R. , Rosen Stuart D. 
Published: May 2014

AimsTo determine the impact of internationally recognized criteria for the diagnosis of heart failure with preserved ejection fraction (HF‐PEF) on the feasibility of recruitment into a HF‐PEF trial.Methods and resultsWe reviewed the medical records of 5883 consecutive patients admitted with heart failure across eight hospitals in the UK. From those who had an EF ≥50% (filter 1), patients who had an alternative cardiac cause of symptoms or an over‐riding co‐morbidity were excluded (filter 2). The remaining patients had to satisfy the following selection criteria (filter 3): the presence of a non‐dilated left ventricle; structural remodelling (LV hypertrophy or dilated left atrium); and evidence of impaired diastolic function or raised BNP. Overall, 20.5% (n = 1203) of patients admitted with heart failure had an EF ≥50%. There was significant heterogeneity between the hospitals as this proportion varied from 42.4% in the teaching hospitals to 13.8% in the district general hospitals (P < 0.0001). Applying filter 2, the cohort size was reduced from 1203 to 122 patients. Of the latter 122, only 45 people had evidence of structural cardiac remodelling and evidence of either raised cardiac filling pressures on echocardiography or raised BNP consistent with HF‐PEF.ConclusionApplying our filters, only 0.8% of all patients admitted with heart failure would be eligible for a HF‐PEF trial. These data have important implications for the feasibility of clinical trials for HF‐PEF and for the generalizability of the results of such studies.
Layered Salts with Iron Hexadecachlorophthalocyanine Anions – The Formation of [{FeCl16Pc}2]3– Dimers Containing [FeICl16Pc(2–)]– and Diamagnetic [Fe0Cl16Pc(2–)]2–
Authors: Konarev Dmitri V. , Kuzmin Alexey V. , Ishikawa Manabu , Nakano Yoshiaki , Faraonov Maxim A. , Khasanov Salavat S. , Otsuka Akihiro , Yamochi Hideki , Saito Gunzi , Lyubovskaya Rimma N. 
Published: May 2014

AbstractIron hexadecachlorophthalocyanine (Cl16Pc) salts with a layered arrangement of phthalocyanine (Pc) macrocycles were obtained by the reduction of FeCl16Pc with sodium fluorenone ketyl in the presence of PPNCl [PPN+: bis(triphenylphosphine)iminium cation] and TBABr (TBA+: tetrabutylammonium cation). (PPN+)[(FeICl16Pc)–]·0.78C6H4Cl2·0.22C6H14 (1) contains π–π stacking columns formed by dimerized (FeICl16Pc)– anions. The side‐by‐side arrangement of neighboring columns results in the formation of a layered iron hexadecachlorophthalocyanine structure. (TBA+)3{[(FeCl16Pc)2]3–} (2) contains hexagonal layers formed by [(FeCl16Pc)2]3– dimers and separated by TBA+ cations. The dimers bear –3 charge and, according to optical and X‐ray diffraction data, consist of a [FeI(Cl16Pc)]– monoanion and a [Fe0(Cl16Pc)]2– dianion. These anions are bonded in the dimer by a Fe–Fe bond of 2.899(4) Å length. It was shown that the negative charge in both anions is localized on the iron atoms to form FeI and Fe0, respectively, and no electron transfer to the hexadecachlorophthalocyanine macrocycles is observed. Magnetic data indicate the presence of only one S = 1/2 spin per [(FeCl16Pc)2]3– dimer. This result is in agreement with the formation of iron(I) and iron(0) hexadecachlorophthalocyanine anions, which have the iron atoms in d7 and diamagnetic d8 electron configuration, respectively. The spins of the iron(I) atoms are arranged in a hexagonal manner and only weakly interact, which results in a Weiss temperature of –1 K because of the long distances between them (>18 Å). Previously studied anionic salts with a columnar arrangement of [FeI(Cl16Pc)]– do not show EPR signals from FeI. In contrast, salt 2 shows an intense EPR signal with main components at g⟂ = 2.249 and g∥ = 1.989, which are characteristic of FeI with d7 electron configuration.
Controlling Helix Handedness in Water‐Soluble Quinoline Oligoamide Foldamers
Authors: Dawson Simon J. , Mészáros Ádám , Pethő Lilla , Colombo Cinzia , Csékei Márton , Kotschy András , Huc Ivan 
Published: May 2014

AbstractFor biological applications, the control of the helix handedness of water‐soluble quinoline‐based oligoamide foldamers has been investigated by the installation of chiral end groups at either the C or N terminus. This has resulted in the development of monomer units capable of unequivocally inducing helical sense without impacting the aqueous solubility. Furthermore, we showed that very slow helix handedness inversion in water can be exploited. The incorporation of a chiral moiety with no handedness‐induction properties allows the chromatographic separation of P and M helices as diastereoisomers with kinetically locked handedness.
A Shuttle for the Transport of Protons Based on a [2]Rotaxane
Authors: Hesseler Britta , Zindler Melanie , Herges Rainer , Lüning Ulrich 
Published: May 2014

AbstractA [2]rotaxane shuttle for (light‐driven) proton transport has been designed and synthesized. The rotaxane contains a macrocyclic ring that carries a pyridine nitrogen atom as a basic center to bind and to transport a proton. The axis includes an amide binding site for the macrocycle and a positive charge in close vicinity. Upon protonation of the pyridine nitrogen atom, the hydrogen bond is broken and Coulomb repulsion between the protonated pyridine and the permanent positive charge in the axis pushes the protonated macrocycle to the other end of the axis. By variation of the pH the ring can shuttle to and fro. Its locations on the axis were determined by NMR spectroscopy.
Personality, Motivation, and College Readiness: A Prospectus for Assessment and Development
Authors: Kyllonen Patrick C. , Lipnevich Anastasiya A. , Burrus Jeremy , Roberts Richard D. 
Published: May 2014

AbstractThis article concerns how noncognitive constructs—personality and motivation—can be assessed and developed to increase students' readiness for college. We propose a general framework to account for personality and motivational differences between students. We review numerous studies showing that personality and motivational factors are related to educational outcomes, from early childhood to adulthood. We discuss various methods for assessing noncognitive factors, ranging from self‐assessments to performance tests. We consider data showing that personality and motivation change over time and find that particular interventions have proven successful in changing particular personality facets, leading to increased achievement. In a final section we propose a strategy for implementing a comprehensive psychosocial skills assessment in middle and high school, which would include setting proficiency standards and providing remedial instruction.
Modeling of fog droplet size distributions from infrared light attenuation measurements
Authors: Awan M.S. , Leitgeb Erich 
Published: May 2014

ABSTRACTIt is demonstrated that optical attenuations recorded at 1‐min time interval in foggy environments can be modeled using two parameters of exponential distribution (hereafter EDSD) that are retrieved by standard iterative procedure. To compute two parameters of the exponential distribution, two experimental measurements are required (e.g. the measurement of liquid water content and the optical attenuations at visible wavelength) that are treated as two linear equations. A performance analysis suggests that the newly computed EDSD parameters having average values of Λ = 5.9815, N0 = 6.0586 are well correlated with the infrared light extinction coefficients and show somewhat better agreement with the calculated attenuations. Copyright © 2014 John Wiley & Sons, Ltd.
The Dow is Killing Me: Risky Health Behaviors and the Stock Market
Authors: Cotti Chad , Dunn Richard A. , Tefft Nathan 
Published: May 2014

AbstractWe investigate how risky health behaviors and self‐reported health vary with the Dow Jones Industrial Average (DJIA) and during stock market crashes. Because stock market indices are leading indicators of economic performance, this research contributes to our understanding of the macroeconomic determinants of health. Existing studies typically rely on the unemployment rate to proxy for economic performance, but this measure captures only one of many channels through which the economic environment may influence individual health decisions. We find that large, negative monthly DJIA returns, decreases in the level of the DJIA, and stock market crashes are widely associated with worsening self‐reported mental health and more cigarette smoking, binge drinking, and fatal car accidents involving alcohol. These results are consistent with predictions from rational addiction models and have implications for research on the association between consumption and stock prices. Copyright © 2014 John Wiley & Sons, Ltd.
Risk factors for tracheal necrosis after total pharyngolaryngectomy
Authors: Fujiki Masahide , Miyamoto Shimpei , Sakuraba Minoru , Nagamatsu Shogo , Hayashi Ryuichi 
Published: May 2014

BackgroundTracheal necrosis is a severe complication of total pharyngolaryngectomy (TPL). The purpose of this retrospective study was to identify risk factors for tracheal necrosis after TPL.MethodsWe performed a retrospective chart review of 177 patients who had undergone TPL. The preoperative, operative, and postoperative variables were examined, and possible risk factors for tracheal necrosis were subjected to univariate analysis and multivariate logistic regression.ResultsTracheal necrosis occurred in 35 patients (19.8%), and tracheoesophageal fistula subsequently developed in 3 of these patients. Multivariate logistic regression analysis identified total esophagectomy and diabetes mellitus as significant risk factors for tracheal necrosis after TPL.ConclusionThe findings of this study will be useful for assessing the risk of tracheal necrosis after TPL. In patients at high risk for tracheal necrosis, efforts should be made to preserve the tracheal circulation and to prevent life‐threatening sequelae if tracheal necrosis occurs. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1207–1210, 2015