bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retention of Metal Crowns Luted to Implant Abutments of Two Different Diameters using Different Luting Agents
Authors: Matani Jay Dipak , Parulekar Natasha , Kheur Mohit , Jambhekar Shantanu , Supriya MK 
Published: July 2013

ABSTRACT

Purpose
The desirable properties of a luting agent used for implant prostheses are adequate tensile strength for retention and at the same time render the crowns to be retrievable. No studies have reported a comparison of the retention of implant crowns luted with zinc phosphate and polymeric cements. Studying the retentive abilities of these cements utilizing varying sizes of implant abutments may provide new insights into their clinical behaviors.

Aim
To compare the retentive abilities of two luting agents, using them to lute crowns on implant abutments of different diameters.

Materials and methods
Two implants (3.7 and 6.0 mm diameter) were embedded in a resin block. Straight abutments of corresponding diameters were screwed into the implants. The height of abutments was kept equal for both abutments (8 mm). Seven copings were fabricated for each abutment. Groups 1 and 2 copings (14 copings) were tested for both luting agents; zinc phosphate and polymeric cement using a universal testing machine.

Results
For the abutment diameters tested, the retentive values of zinc phosphate was significantly greater than polymeric implant cement. For the broad abutment, zinc phosphate was significantly more retentive than polymeric implant cement. For the narrow abutment, retentive values of zinc phosphate and polymeric implant cement were almost similar.

Conclusion
The retentive values of zinc phosphate were significantly greater than polymeric implant cement. For broad abutment, zinc phosphate was more retentive whereas for narrow abutment, retentive values were almost similar.

How to cite this article
Matani JD, Parulekar N, Kheur M, Jambhekar S, Supriya MK. Retention of Metal Crowns Luted to Implant Abutments of Two Different Diameters using Different Luting Agents. Int J Prosthodont Restor Dent 2012;2(3):96-100.
Designing a Nasal Prosthesis using CAD-RP Technology
Authors: Vanitha R , Ramkumar K , Rajtilak G , Rajasekar V 
Published: July 2013

ABSTRACT
A 37-year-old female patient reported to the hospital with a nasal defect due to carcinoma. She was previously restored with nasal prostheses, but was not satisfied with its cosmetic appeal. A computerized tomographic (CT) scan of the defect area was made and converted into 3- dimensional (3D) digital data using dedicated medical imaging software. From the 3D image, measurements of the defect were calculated and compared with various nasal fossa measurements available in the digital database. A 3D nose model which had measurements that closely matched the defect area was extracted and superimposed on the defect area and margins adjusted. The data files were then sent for rapid prototyping (RP). A RP model was fabricated which was duplicated in wax and processed. The final result was a nasal prosthesis that conformed well to the patients’ face and was also esthetically acceptable. The main advantage of computer-aided designing (CAD)-RP is that it allows trying various nasal forms on the patients face within few hours. This saves chair time, eliminates the impression step and provides patient and dentist an option of variety.

How to cite this article
Vanitha R, Ramkumar K, Rajtilak G, Rajasekar V. Designing a Nasal Prosthesis using CAD-RP Technology. Int J Prosthodont Restor Dent 2012;2(3):108-112.
Anterior Teeth and Smile Designing: A Prospective View
Authors: Vanitha R , Rajasekar V , Rajtilak G , Deepa S 
Published: July 2013

ABSTRACT
Smile is a person's greatest beauty asset. A defective smile might be considered as a physical handicap as the mouth act as a focal point where a large share of attention is directed toward mouth and teeth, it would be nice to have some sort of tools to assess beauty, which currently does not exist.
Standards for beauty are actually a compilation and comparison of everything we have seen or experienced. Smile design is different from tooth design, with tooth design one is concerned with contour, position and color of individual teeth, while integration of these teeth into the face and facial features is paramount in smile design.
This article describes some average desirable characteristic features of smile to help and achieve optimum result in esthetic oral rehabilitation.

How to cite this article
Rajtilak G, Deepa S, Rajasekar V, Vanitha R. Anterior Teeth and Smile Designing: A Prospective View. Int J Prosthodont Restor Dent 2012;2(3):117-127.
Risks of Placental Abruption and Preterm Delivery in Patients Undergoing Assisted Reproduction
Authors: Zhang Jennifer T. , Lee Rachel , Sauer Mark V. , Ananth Cande V. 
Published: July 2024

ImportancePatients using assisted reproductive technology (ART) may need additional counseling about the increased risks of placental abruption and preterm delivery. Further investigation into the potential additive risk of ART and placental abruption is needed.ObjectiveTo ascertain the risk of placental abruption in patients who conceived with ART and to evaluate if placental abruption and ART conception are associated with an increased risk of preterm delivery (&amp;lt;37 weeks’ gestation) over and above the risks conferred by each factor alone.Design, Setting, and ParticipantsThis cross-sectional study used data from the National Inpatient Sample, which includes data from all-payer hospital inpatient discharges from 48 states across the US. Participants included women aged 15 to 54 years who delivered from 2000 through 2019. Data were analyzed from January 17 to April 18, 2024.ExposuresPregnancies conceived with ART.Main Outcomes and MeasuresRisks of placental abruption and preterm delivery in ART conception compared with spontaneous conceptions. Associations were expressed as odds ratios (ORs) and 95% CIs derived from weighted logistic regression models before and after adjusting for confounders. The relative excess risk due to interaction (RERI) of the risk of preterm delivery based on ART conception and placental abruption was also assessed.ResultsOf 78 901 058 deliveries, the mean (SD) maternal age was 27.9 (6.0) years, and 9 212 117 patients (11.7%) were Black individuals, 14 878 539 (18.9%) were Hispanic individuals, 34 899 594 (44.2%) were White individuals, and 19 910 807 (25.2%) were individuals of other races and ethnicities. Of the total hospital deliveries, 98.2% were singleton pregnancies, 68.8% were vaginal deliveries, and 52.1% were covered by private insurance. The risks of placental abruption among spontaneous and ART conceptions were 11 and 17 per 1000 hospital discharges, respectively. After adjusting for confounders, the adjusted OR (AOR) of placental abruption was 1.42 (95% CI, 1.34-1.51) in ART pregnancies compared with spontaneous conceptions, with increased odds in White women (AOR, 1.42; 95% CI, 1.31-1.53) compared with Black women (AOR, 1.16; 95% CI, 0.93-1.44). The odds of preterm delivery were significantly higher in pregnancies conceived by ART compared with spontaneous conceptions (AOR, 1.46; 95% CI, 1.42-1.51). The risk of preterm delivery increased when patients had both ART conception and placental abruption (RERI, 2.0; 95% CI, 0.5-3.5).Conclusions and RelevanceIn this cross-sectional study, patients who conceived using ART and developed placental abruption had a greater risk of preterm delivery compared with spontaneous conception without placental abruption. These findings have implications for counseling patients who seek infertility treatment and obstetrical management of ART pregnancies.
Wild lions in small, fenced reserves in South Africa conform to a meta‐population
Authors: Selier Jeanetta , Miller Susan M. , Coverdale Brent , Ferreira Sam , Kruger Johan , Parker Dan M. 
Published: July 2024

Abstract

Lions (Panthera leo) are declining across their range, mainly due to human‐induced habitat fragmentation and prey depletion. However, the South African lion population continues to grow. Unlike other range states, South Africa actively manages wild lions across a continuum of landscapes and ecological constraints. Many of these lions are in small, fenced reserves where managers seek to mimic ecological processes in small landscapes. However, the effectiveness of this management approach has not been evaluated against meta‐population criteria.

Given that meta‐population dynamics allows species living in fragmented habitats to persist, we evaluated how South Africa's lion population complies with meta‐population criteria using national audit data between 2010 and 2019 from 49 fenced, wild lion reserves.

The small, fenced reserves holding wild lions fulfil the criteria for meta‐population functionality. However, this functionality was achieved through haphazard and uncoordinated management actions and not through a coordinated approach.

Our main recommendation is to consider implementing a more coordinated meta‐population management approach. At the very least, meta‐population management guidelines should be reviewed and updated on a regular basis, regular audits should be conducted and periodic genetic evaluation of the meta‐population (every 10 years) should be instituted. We recommend incentivising lion managers to enhance the conservation of lions in South Africa within a meta‐population framework. We also recommend a focus on improving decision making and policy procedures that facilitates compliance with relevant legislation aimed at achieving high levels of lion conservation‐governance efficiency.

South Africa's meta‐population approach to wild lion management in small, fenced reserves is effective at conserving lions and contributing to lion conservation more broadly. In an increasingly fragmented landscape, the need for human management actions to ensure persistence of large carnivores is likely to increase. A managed meta‐population approach of fenced (or unfenced, but geographically isolated) populations is a useful tool for conservationists to consider worldwide.
Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist‐Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study
Authors: Lawford Belinda J. , Allison Kim , Nelligan Rachel , Campbell Penny , Hinman Rana S. , Jones Sarah E. , Pardo Jesse , Quicke Jonathan G. , Sumithran Priya , Prendergast Jodie , George Elena S. , Holden Melanie A. , Foster Nadine E. , Bennell Kim L. 
Published: July 2024

ObjectiveExplore the experiences of people with knee osteoarthritis (OA) who received a very low energy diet (VLED) and exercise program from a physiotherapist.MethodsMixed methods study involving questionnaires (n = 42) and semistructured interviews (n = 22) with randomized control trial participants with knee OA who had received a 6‐month physiotherapist‐delivered VLED weight loss and exercise intervention. Questionnaires measured participant satisfaction and perceptions about physiotherapist's skills/knowledge in delivery of the dietary intervention (measured on 5–7 point Likert scales). Interviews explored participant's experiences and were analyzed based on the principles of reflexive thematic analysis.ResultsQuestionnaire response: 90%. Participants were satisfied with the program (95%), confident their physiotherapist had the required skills (84%) and knowledge (79%) to deliver the dietary intervention, felt comfortable talking to the physiotherapist about weight (74%), and would recommend others see a physiotherapist for the intervention they undertook (71%). The following four themes were developed from the interviews: (1) one‐stop‐shop of exercise and diet; (2) physiotherapist‐delivered weight loss works (unsure initially; successfully lost weight); (3) physiotherapists knowledge and skills (exercise is forte; most thought physiotherapists had the necessary weight loss skills/knowledge, but some disagreed); and (4) physiotherapists have a role in weight loss (physiotherapists are intelligent, credible, and trustworthy; specific training in weight loss necessary).ConclusionThis study provides, to our knowledge, the first documented perspectives from people with OA who have received a physiotherapist‐delivered weight loss intervention. Findings suggest physiotherapists may have a role in delivering a protocolized dietary intervention for some people with knee OA with overweight and obesity.
Charting a Path to Tumor Therapy: Mastery of Luminescent Metal–Organic Frameworks for Precise Spatiotemporal Control
Authors: Gao Renchi , Xu Tianxing , Wang Zhao , Ren Hong‐Xia , Zhang Gonghao , Zhao Yang , Tay Andy , Miao Yang‐Bao 
Published: July 2024

AbstractThe field of drug delivery has significantly advanced tumor therapy, yet challenges such as the predictability of treatment outcomes and the real‐time monitoring of tumor progression, such as recurrence or metastasis. Luminescent metal–organic frameworks (L‐MOFs) are a promising solution to overcome these issues. This review offers a comprehensive exploration of the design and synthesis of L‐MOFs, presenting their crucial optical properties. The review highlights the pivotal role of L‐MOFs in enabling precision medicine for tumor treatment driven by their performance. Through strategically harnessing light‐manipulated metal–organic frameworks (MOFs), real‐time therapeutic monitoring and precise spatiotemporal control in tumor treatment can be achieved. Moreover, this review meticulously examines the influence of photomanipulating MOFs on in situ drug synthesis, introducing the catalytic role in light‐manipulated gas therapy. Additionally, the role of L‐MOFs as gene therapy vectors that utilize light to trigger gene expression responses is also comprehensively explored in the article, aiming to highlight their role in enabling tumor therapy through gene therapy. The review concludes by proposing an artificial intelligence (AI)‐mediated blueprint for tumor treatment with L‐MOFs, aiming to pave the way for innovative approaches through light manipulation.
Protosappanin A Protects DOX‐Induced Myocardial Injury and Cardiac Dysfunction by Targeting ACSL4/FTH1 Axis‐Dependent Ferroptosis
Authors: Cui Jingxuan , Chen Yujia , Yang Qiannan , Zhao Peng , Yang Mian , Wang Xiaoqi , Mang Ge , Yan Xiangyu , Wang Di , Tong Zhonghua , Wang Penghe , Kong Yingjin , Wang Naixin , Wang Dongni , Dong Nana , Liu Mingyang , E Mingyan , Zhang Maomao , Yu Bo 
Published: July 2024

AbstractDoxorubicin (DOX) is an effective anticancer agent, but its clinical utility is constrained by dose‐dependent cardiotoxicity, partly due to cardiomyocyte ferroptosis. However, the progress of developing cardioprotective medications to counteract ferroptosis has encountered obstacles. Protosappanin A (PrA), an anti‐inflammatory compound derived from hematoxylin, shows potential against DOX‐induced cardiomyopathy (DIC). Here, it is reported that PrA alleviates myocardial damage and dysfunction by reducing DOX‐induced ferroptosis and maintaining mitochondrial homeostasis. Subsequently, the molecular target of PrA through proteome microarray, molecular docking, and dynamics simulation is identified. Mechanistically, PrA physically binds with ferroptosis‐related proteins acyl‐CoA synthetase long‐chain family member 4 (ACSL4) and ferritin heavy chain 1 (FTH1), ultimately inhibiting ACSL4 phosphorylation and subsequent phospholipid peroxidation, while also preventing FTH1 autophagic degradation and subsequent release of ferrous ions (Fe2+) release. Given the critical role of ferroptosis in the pathogenesis of ischemia‐reperfusion (IR) injury, this further investigation posits that PrA can confer a protective effect against IR‐induced cardiac damage by inhibiting ferroptosis. Overall, a novel pharmacological inhibitor is unveiled that targets ferroptosis and uncover a dual‐regulated mechanism for cardiomyocyte ferroptosis in DIC, highlighting additional therapeutic options for chemodrug‐induced cardiotoxicity and ferroptosis‐triggered disorders.
Metal‐Doping Strategy for Carbon‐Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma
Authors: Cheng Mingming , Liu Yan , You Qiannan , Lei Zhubing , Ji Jiajian , Zhang Fan , Dong Wen‐Fei , Li Li 
Published: July 2024

AbstractGlioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) is an innovative therapeutic approach that shows promise in tumor elimination by activating sonosensitizers with low‐intensity ultrasound. In this study, a novel sonosensitizer is synthesized using Cu‐doped carbon dots (Cu‐CDs) for the sonodynamic treatment of GBM. Doping with copper transforms the carbon dots into a p–n type semiconductor having a bandgap of 1.58 eV, a prolonged lifespan of 10.7 µs, and an improved electron‐ and hole‐separation efficiency. The sonodynamic effect is efficiency enhanced. Western blot analysis reveals that the Cu‐CDs induces a biological response leading to cell death, termed as cuproptosis. Specifically, Cu‐CDs upregulate dihydrosulfanyl transacetylase expression, thereby establishing a synergistic therapeutic effect against tumor cell death when combined with SDT. Furthermore, Cu‐CDs exhibit excellent permeability through the blood‐brain barrier and potent anti‐tumor activity. Importantly, the Cu‐CDs effectively impede the growth of glioblastoma tumors and prolong the survival of mice bearing these tumors. This study provides support for the application of carbon‐based nanomaterials as sonosensitizers in tumor therapy.
De Novo Synthesis of α‐Ketoamides via Pd/TBD Synergistic Catalysis
Authors: Chen Jia‐He , Zhang Li‐Ren , Wang Zhang‐Yang , Liu Lu‐Jie , Tu Li‐Ping , Zhang Yun , Chen Yong‐Zheng , Han Wen‐Yong 
Published: July 2024

AbstractPrecisely controlling the product selectivity of a reaction is an important objective in organic synthesis. α‐Ketoamides are vital intermediates in chemical transformations and privileged motifs in numerous drugs, natural products, and biologically active molecules. The selective synthesis of α‐ketoamides from feedstock chemicals in a safe and operationally simple manner under mild conditions is a long‐standing catalysis challenge. Herein, an unprecedented TBD‐switched Pd‐catalyzed double isocyanide insertion reaction for assembling ketoamides in aqueous DMSO from (hetero)aryl halides and pseudohalides under mild conditions is reported. The effectiveness and utility of this protocol are demonstrated by its diverse substrate scope (93 examples), the ability to late‐stage modify pharmaceuticals, scalability to large‐scale synthesis, and the synthesis of pharmaceutically active molecules. Mechanistic studies indicate that TBD is a key ligand that modulates the Pd‐catalyzed double isocyanide insertion process, thereby selectively providing the desired α‐ketoamides in a unique manner. In addition, the imidoylpalladium(II) complex and α‐ketoimine amide are successfully isolated and determined by X‐ray analysis, confirming that they are probable intermediates in the catalytic pathway.
Hydrophobic Microenvironment Modulation of Ru Nanoparticles in Metal–Organic Frameworks for Enhanced Electrocatalytic N2 Reduction
Authors: Wen Lulu , Liu Xiaoshuo , Li Xinyang , Zhang Hanlin , Zhong Shichuan , Zeng Pan , Shah Syed Shoaib Ahmad , Hu Xiaoye , Cai Weiping , Li Yue 
Published: July 2024

AbstractThe modulation of the chemical microenvironment surrounding metal nanoparticles (NPs) is an effective means to enhance the selectivity and activity of catalytic reactions. Herein, a post‐synthetic modification strategy is developed to modulate the hydrophobic microenvironment of Ru nanoparticles encapsulated in a metal–organic framework (MOF), MIP‐206, namely Ru@MIP‐Fx (where x represents perfluoroalkyl chain lengths of 3, 5, 7, 11, and 15), in order to systematically explore the effect of the hydrophobic microenvironment on the electrocatalytic activity. The increase of perfluoroalkyl chain length can gradually enhance the hydrophobicity of the catalyst, which effectively suppresses the competitive hydrogen evolution reaction (HER). Moreover, the electrocatalytic production rate of ammonia and the corresponding Faraday efficiency display a volcano‐like pattern with increasing hydrophobicity, with Ru@MIP‐F7 showing the highest activity. Theoretical calculations and experiments jointly show that modification of perfluoroalkyl chains of different lengths on MIP‐206 modulates the electronic state of Ru nanoparticles and reduces the rate‐determining step for the formation of the key intermediate of N2H2*, leading to superior electrocatalytic performance.
Sub‐Micron Replication of Fused Silica Glass and Amorphous Metals for Tool‐Based Manufacturing
Authors: Kluck Sebastian , Prediger Richard , Hambitzer Leonhard , Nekoonam Niloofar , Dreher Franziska , Luitz Manuel , Lunzer Markus , Worgull Matthias , Schneider Marc , Rapp Bastian E. , Kotz‐Helmer Frederik 
Published: July 2024

AbstractThe growing importance of submicrometer‐structured surfaces across a variety of different fields has driven progress in light manipulation, color diversity, water‐repellency, and functional enhancements. To enable mass production, processes like hot‐embossing (HE), roll‐to‐roll replication (R2R), and injection molding (IM) are essential due to their precision and material flexibility. However, these processes are tool‐based manufacturing (TBM) techniques requiring metal molds, which are time‐consuming and expensive to manufacture, as they mostly rely on galvanoforming using templates made via precision microlithography or two‐photon‐polymerization (2PP). In this work, a novel approach is demonstrated to replicate amorphous metals from fused silica glass, derived from additive manufacturing and structured using hot embossing and casting, enabling the fabrication of metal insets with features in the range of 300 nm and a surface roughness of below 10 nm. By partially crystallizing the amorphous metal, during the replication process, the insets gain a high hardness of up to 800 HV. The metal molds are successfully used in polymer injection molding using different polymers including polystyrene (PS) and polyethylene (PE) as well as glass nanocomposites. This work is of significant importance to the field as it provides a production method for the increasing demand for sub‐micron‐structured tooling in the area of polymer replication while substantially reducing their cost of production.
Structures, magnetism, and oxygen evolution reaction (OER) of azidoisophthalate bridging Cu(II) and Co(II) coordination polymers
Authors: Ahmed Sabir , Sarkar Koushik , Samanta Arnab , Sinha Chittaranjan 
Published: July 2024

Two newly derived coordination polymers of Cu(II) and Co(II), namely {[Cu(μ‐5‐AzIA)(Py)2]⋅[Cu(5‐AzIA)(Py)2(H2O)]}n (CP1) and {[Co(μ‐5‐AzIA)2(Py)4]⋅[Co(5‐AzIA)(Py)2]}n (CP2) (5‐AzIA2− = 5‐azidoisophthalate; Py = pyridine) are synthesized and structurally characterized by single‐crystal X‐ray diffraction (SXRD), powder X‐ray diffraction (PXRD), and Fourier transform infrared data. As evident from thermogravimetric data, CP1 loses coordinated water at 110°C and the final residue reaches at 530°C as CuO; CP2 is stable up to 150°C, and the final residue reaches at 415°C as Co2O3. 5‐AzIA2− serves as both chelating and monodentate carboxylate bridging ligand to the adjacent metal centers (Cu(II) in CP1 and Co(II) in CP2) to construct the CPs. The CPs form eight‐member carboxylato bridging, [M2(RCOO)2], and coordinate with Py rings and assemblage through π‐‐‐π interaction. The magnetic measurements of the CPs show antiferromagnetic super‐exchange properties. Interestingly, CP2 shows field‐induced magnetic ordering at a higher magnetic field at a temperature ̴ 2 K owing to the π•••π stacking between the flagging pyridine moieties. Oxygen evolution reaction (OER) shows excellent catalytic effectiveness of CP2 than CP1 with reference to standard RuO2 catalyst. The comparative catalytic activity of CP1 and CP2 was thoroughly investigated and well supported by Tafel slope, charge‐transfer resistance (Rct), and electrochemically active surface area calculation.