bluuebunny/crossref_metadata_2025_split huggingface dataset:
Groundwater and Economic Dynamics, Shadow Rents and Shadow Prices: The Punjab
Authors: Smith Rodney B. W. , Nelson Harumi , Roe Terry L. 
Published: October 2015

This study investigates the effect of electricity subsidies on economic and groundwater dynamics. The analysis follows from a dynamic, multisector and general equilibrium model in which both aquifer hydrology dynamics in the Punjab region of India and capital accumulation across India are endogenous. The model predicts Punjabi aquifer depletion which has distinct regional impacts and slight spillovers on the rest of the Indian economy. From the Punjab perspective, electricity subsidies encourage higher levels of groundwater extraction than one would observe in the absence of the subsidy. In turn, the higher levels of groundwater extraction increase agriculture's ability to compete for labor and other farm inputs. Even with the subsidy, however, as the economy transitions to the long run equilibrium, groundwater tables fall and more electricity is needed to supply the same amount of water used in the previous period. These forces slowly diminish agriculture's ability to compete for resources and the sector eventually loses resources to the rest of the economy and in turn, agricultural income falls over time. These dynamics are accentuated when the subsidy is removed, leading to a more rapid decline in Punjabi agricultural income. Our empirical findings suggest eliminating the 'electricity for irrigation' subsidy leads to double gains: An environmental gain and an economic gain. The environmental gain is a slower rate of aquifer depletion over time relative to a subsidy world. Removing the subsidy discourages production of high water-intensive crops, thus slowing the rate of groundwater extraction. Although removing the subsidy increases agricultural production costs, it makes electricity less expensive for competing sectors, namely manufacturing, which in turn leads, over time, to increased electricity, capital and labor demand from manufacturing. This reallocation of resources to more productive sectors in the economy leads to an increase in Punjabi gross state domestic product, as compared to the case where electricity is subsidized. The empirical results suggest removing Punjabi electricity subsidies entails trade-offs between agricultural and manufacturing income and has implications for long term water use. Empirical results also suggest that correctly calculating the "stock" value of a natural resource requires macroeconomic data and hence, may be impossible to conduct in a partial equilibrium setting.
Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors
Authors: Sarantopoulos John , Shapiro Geoffrey I. , Cohen Roger B. , Clark Jeffrey W. , Kauh John S. , Weiss Glen J. , Cleary James M. , Mahalingam Devalingam , Pickard Michael D. , Faessel Hélène M. , Berger Allison J. , Burke Kristine , Mulligan George , Dezube Bruce J. , Harvey R. Donald 
Published: October 2015

Abstract
Purpose: To determine the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) of the investigational NEDD8-activating enzyme (NAE) inhibitor pevonedistat (TAK-924/MLN4924) and to investigate pevonedistat pharmacokinetics and pharmacodynamics in patients with advanced nonhematologic malignancies.
Experimental Design: Pevonedistat was administered via 60-minute intravenous infusion on days 1 to 5 (schedule A, n = 12), or days 1, 3, and 5 (schedules B, n = 17, and C, n = 19) of 21-day cycles. Schedule B included oral dexamethasone 8 mg before each pevonedistat dose. Dose escalation proceeded using a Bayesian continual reassessment method. Tumor response was assessed by RECIST 1.0.
Results: Schedule A MTD was 50 mg/m2; based on the severity of observed hepatotoxicity, this schedule was discontinued. Schedules B and C MTDs were 50 and 67 mg/m2, respectively. DLTs on both these schedules included hyperbilirubinemia and elevated aspartate aminotransferase. There were no grade ≥3 treatment-related serious adverse events reported on schedules B or C. Twenty-three (74%) evaluable patients on schedules B and C had stable disease. Intermittent dexamethasone use did not significantly influence pevonedistat pharmacokinetics. NAE inhibition by pevonedistat was demonstrated in multiple tumor types via IHC detection of pevonedistat-NEDD8 adduct and accumulation of Cullin-RING ligase substrates CDT1 and NRF2 in tumor biopsies.
Conclusions: Pevonedistat was generally well tolerated on a day 1, 3, 5 schedule every 3 weeks with an MTD between 50 mg/m2 and 67 mg/m2. DLTs were predominantly hepatic enzyme elevations. Pharmacodynamic studies demonstrated that pevonedistat inhibited NAE in tumors. Clinical trials are ongoing. Clin Cancer Res; 22(4); 847–57. ©2015 AACR.
“PEAR-ing” Genomic and Epigenomic Analyses for Cancer Gene Discovery
Authors: Mack Stephen C. , Rich Jeremy N. , Scacheri Peter C. 
Published: October 2015

Abstract
Summary: Somatic structural variants in tumor genomes can deregulate transcription through repositioning of enhancer elements. A new method, PEAR-ChIP, leverages paired-end H3K27ac chromatin immunoprecipitation combined with high-throughput sequencing and current computational methods to identify such events. Cancer Discov; 5(10); 1018–20. ©2015 AACR.
See related article by Ryan et al., p. 1058.
Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention
Authors: Roest Mark , McClellan Elizabeth A. , Sels Jan W. , Stubbs Andrew , Jukema J. Wouter , Doevendans Pieter A. , Waltenberger Johannes , Zonneveld Anton-Jan van , Pasterkamp Gerard , Rutten Bert , Groot Philip G. de , Hoefer Imo E. 
Published: October 2015

SummaryMonocyte recruitment to damaged endothelium is enhanced by platelet binding to monocytes and contributes to vascular repair. Therefore, we studied whether the number of platelets per monocyte affects the recurrence of adverse events in patients after percutaneous coronary intervention (PCI). Platelet-monocytes complexes with high and low median fluorescence intensities (MFI) of the platelet marker CD42b were isolated using cell sorting. Microscopic analysis revealed that a high platelet marker MFI on monocytes corresponded with a high platelet density per monocyte while a low platelet marker MFI corresponded with a low platelet density per monocyte (3.4 ± 0.7 vs 1.4 ± 0.1 platelets per monocyte, P=0.01). Using real-time video microscopy, we observed increased recruitment of high platelet density monocytes to endothelial cells as compared with low platelet density monocytes (P=0.01). Next, we classified PCI scheduled patients (N=263) into groups with high, medium and low platelet densities per monocyte and assessed the recurrence of adverse events. After multivariate adjustment for potential confounders, we observed a 2.5-fold reduction in the recurrence of adverse events in patients with a high platelet density per monocyte as compared with a low platelet density per monocyte [hazard ratio=0.4 (95 % confidence interval, 0.2–0.8), P=0.01]. We show that a high platelet density per monocyte increases monocyte recruitment to endothelial cells and predicts a reduction in the recurrence of adverse events in patients after PCI. These findings may imply that a high platelet density per monocyte protects against recurrence of adverse events.Supplementary Material to this article is available online at www.thrombosis-online.com.
F11 is associated with recurrent VTE in women
Authors: Bruzelius Maria , Ljungqvist Maria , Bottai Matteo , Bergendal Annica , Strawbridge Rona J. , Holmström Margareta , Silveira Angela , Kieler Helle , Hamsten Anders , Lärfars Gerd , Odeberg Jacob 
Published: October 2015

SummaryGenetic associations for the reoccurrence of venous thromboembolism (VTE) are not well described. Our aim was to investigate if common genetic variants, previously found to contribute to the prediction of first time thrombosis in women, were associated with risk of recurrence. The Thromboembolism Hormone Study (TEHS) is a Swedish nationwide case-control study (2002–2009). A cohort of 1,010 women with first time VTE was followed up until a recurrent event, death or November 2011. The genetic variants in F5 rs6025, F2 rs1799963, ABO rs514659, FGG rs2066865, F11 rs2289252, PROC rs1799810 and KNG1 rs710446 were assessed together with clinical variables. Recurrence rate was calculated as the number of events over the accumulated patient-time. Cumulative recurrence was calculated by Kaplan-Meier curve. Cox proportional-hazard model was used to estimate hazard ratios (HR) and 95 % confidence intervals (95 % CI) between groups. A total of 101 recurrent events occurred during a mean follow-up time of five years. The overall recurrence rate was 20 per 1,000 person-years (95 % CI; 16-24). The recurrence rate was highest in women with unprovoked first event and obesity. Carriers of the risk alleles of F5 rs6025 (HR=1.7 (95 % CI; 1.1–2.6)) and F11 rs2289252 (HR=1.8 (95 % CI; 1.1–3.0)) had significantly higher rates of recurrence compared to non-carriers. The cumulative recurrence was 2.5-fold larger in carriers of both F5 rs6025 and F11 rs2289252 than in non-carriers at five years follow-up. In conclusion, F5 rs6025 and F11 rs2289252 contributed to the risk of recurrent VTE and the combination is of potential clinical relevance for risk prediction.Supplementary Material to this article is available online at www.thrombosis-online.com.
Single bumblebee leaving colony for first time seeks company
Authors: Walker C.M. , Plowright C.M.S. 
Published: October 2015

For social learning to occur in bumblebees, individuals must first be drawn to the relevant stimuli from which to learn. Here we investigate whether bumblebees (Bombus impatiens) leaving their colony for the first time are drawn to other live bees. In Experiment 1, flower-naïve workers were tested for their preferences of stimuli presented in a radial maze. Live bees, artificial floral patterns and black disks were presented at two different densities (1 vs 6 objects). A marked preference for the six live bees was obtained. Experiment 2 isolated the variable of movement: black disks vs dead bees were presented on a platform that was either stationary or rotating. A preference for moving over stationary displays was obtained, as well as a preference for displays comprising bees rather than disks. Flower-naïve bumblebees leave their nest equipped with behavioural tendencies that can serve to initiate new social encounters from which to learn.
Low-Frequency Variability of the South Pacific Subtropical Gyre as Seen from Satellite Altimetry and Argo
Authors: Zhang Linlin , Qu Tangdong 
Published: October 2015

AbstractLow-frequency variability of the South Pacific Subtropical Gyre is investigated using satellite altimeter and Argo data. In most of the region studied, both sea surface height and steric height exhibit a linearly increasing trend, with its largest amplitude in the western part of the basin. Analysis of the Argo data reveals that the steric height increase north of 30°S is primarily caused by variations in the upper 500 m, while the steric height increase south of 30°S is determined by variations in the whole depths from the sea surface to 1800 m, with contributions from below 1000 m accounting for about 50% of the total variance. Most of the steric height increase is due to thermal expansion, except below 1000 m where haline contraction is of comparable magnitude with thermal expansion. Correspondingly, the South Pacific Subtropical Gyre has strengthened in the past decade. Within the latitude range between 10° and 35°S, transport of the gyre circulation increased by 20%–30% in the upper 1000 m and by 10%–30% in the deeper layers from 2004 to 2013. Further analysis shows that these variations are closely related to the southern annular mode in the South Pacific.
Stereotactic Radiotherapy in the Retreatment of Recurrent Cervical Cancers, Assessment of Toxicity, and Treatment Response
Authors: Pontoriero Antonio , Iatì Giuseppe , Aiello Dario , Pergolizzi Stefano 
Published: October 2015

Aim: To evaluate the role of stereotactic body radiation therapy in the retreatment of locally recurrent cervical cancers. Brachytherapy is the main choice to treat gynecologic cancers. Methods: Patients with recurrent cervical cancer, previously submitted to radiotherapy, were treated with stereotactic body radiation therapy using a CyberKnife system (Accuray Incorporated, Sunnyvale, California) with a fiducial tracking system. Results: From August 2011 to October 2014, 5 patients have been treated. Median age was 81 years (range, 70-84 years). Two patients were diagnosed with adenocarcinoma endometrioid and 3 with squamous cell carcinoma. Toxicity was scored according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. After a median follow-up of 12 months (range, 8-34 months), no severe (>grade 3) acute/late genitourinary or low gastrointestinal toxicity was observed. Conclusion: Our preliminary results of stereotactic body radiation therapy “simulating” high dose rate for recurrent cervical cancers confirm a minimal toxicity and an optimal outcome. The stereotactic body radiation therapy is an alternative to high dose rate brachytherapy for gynecologic tumors.
Risk of new-onset diabetes associated with statin use
Authors: Beckett Robert D , Schepers Sarah M , Gordon Sarah K 
Published: October 2015

Objective: To identify and assess studies investigating the association between statins and new-onset diabetes and determine the clinical significance of this risk. Data sources: A MEDLINE (1977–April 2015), Google Scholar (1997–April 2015), and International Pharmaceutical Abstracts (1977–April 2015) search was performed using the search terms hydroxymethylglutaryl-CoA reductase inhibitors, hydroxymethylglutaryl-CoA reductase inhibitors/adverse effects, statins, adverse effects, diabetes mellitus, diabetes mellitus/etiology, and drug-induced. Citations of identified articles and clinical practice guidelines were also reviewed. Study selection and data extraction: Articles describing results from original investigations or meta-analyses specifically designed to assess the association between statins and new-onset diabetes and published in English were included. Data synthesis: A total of 13 cohort studies and seven meta-analyses were included. In all, 11 were retrospective cohort studies and reported some degree of increased risk of new-onset diabetes associated with statins. The two prospective cohort studies differed. One identified increased risk of new-onset diabetes, but the other did not. Increased risk was not identified when any statin was compared to placebo alone, individual statins were compared, or in the single meta-analysis that included observational studies. Overall, the meta-analyses suggest that statin therapy is associated with an increased risk of new-onset diabetes when compared to placebo or active control, and when intensive therapy is compared to moderate therapy. Conclusion: Statins have been associated with a small, but statistically significant risk of new-onset diabetes. Patients with risk factors for developing diabetes mellitus may be at higher risk. This risk is likely outweighed by the benefits of reducing cardiovascular risk.
Comparison of Short-Term Outcomes of Geriatric Distal Femur and Femoral Neck Fractures
Authors: Konda Sanjit R. , Pean Christian A. , Goch Abraham M. , Fields Adam C. , Egol Kenneth A. 
Published: October 2015

Purpose: To compare and contrast postoperative complications in the geriatric population following open reduction and internal fixation (ORIF) for (DF) fractures relative to femoral neck (FN) fractures. Methods: Patients aged 65 years and older in the American College of Surgeons National Surgical Quality Improvement Program database who underwent ORIF for FN fractures or DF fractures from 2005 to 2012 were identified. Differences in rates of any adverse events (AAEs), serious adverse events (SAEs), infectious complications, and mortality between groups were explored using univariate and multivariate analyses. Results: The DF cohort had a higher proportion of females (81.95% vs 71.35%, P < .001), were younger (79.41 ± 7.93 vs 82.11 ± 7.26 years old, P < .001), and had a lower age adjusted modified Charlson comorbidity index score (4.22 ± 1.32 vs 4.49 ± 1.35, P = .02). Cases with DF and FN did not differ in AAE (20.05% vs 20.20%, P = .94), SAE (12.03% vs 13.19%, P = .51), infectious complication (4.26% vs 4.22%, P = .97), hospital length of stay (7.32 ± 6.73 days vs 7.02 ± 10.67 days, P = .59), or mortality rates (4.51% vs 5.99%, P = .23). Multivariate analyses revealed that fracture type did not impact AAE ( P = .28), SAE ( P = .58), infectious complications ( P = .83), or mortality ( P = .85) rates. Conclusion: Postoperative morbidity and mortality of geriatric patients who sustain DF and FN fractures treated operatively were comparable. This information can be used when risk stratifying and prognosticating for elderly patients undergoing these procedures.
Psychiatric morbidity and socio-occupational dysfunction in residents of a drug rehabilitation centre: challenges of substance misuse management in a Bruneian context
Authors: Ho Hilda , Adanan Anddy Maz , Omar Radiah 
Published: October 2015

Aims and methodIn 2011, a psychiatric clinic was started in Pusat Al-Islah, a drug rehabilitation centre. Our aim was to record self-reported socio-occupational dysfunction and patterns of drug misuse and to evaluate the usefulness of a psychiatric screening tool. A two-phased approach using the Self-Reporting Questionnaire (SRQ) and the Mini International Neuropsychiatric Interview (MINI) was used to examine the rates of psychiatric diagnoses.ResultsMethamphetamine was the most commonly misused substance in 94.5% of residents. High levels of socio-occupational dysfunction were reported. In total, 5.5% met criteria for major depressive disorder, 4.8% for lifetime psychotic disorder and 11.5% for suicidal ideation. In addition, 13.3% reported previous untreated mental health problems.Clinical implicationsA screening tool such as the SRQ can be used to identify those needing further psychiatric assessment. Interventions to address amphetamine misuse and associated socio-occupational dysfunction are required. Societal views and legislation influence the management of substance misuse problems in Brunei.
Slipped capital femoral epiphysis
Authors: Clement N. D. , Vats A. , Duckworth A. D. , Gaston M. S. , Murray A. W. 
Published: October 2015

Controversy remains whether the contralateral hip should be fixed in patients presenting with unilateral slipped capital femoral epiphysis (SCFE). This retrospective study compares the outcomes and cost of those patients who had prophylactic fixation with those who did not.Between January 2000 and December 2010 a total of 50 patients underwent unilateral fixation and 36 had prophylactic fixation of the contralateral hip. There were 54 males and 32 females with a mean age of 12.3 years (9 to 16). The rate of a subsequent slip without prophylactic fixation was 46%. The risk of complications was greater, the generic health measures (Short Form-12 physical (p < 0.001) and mental (p = 0.004) summary scores) were worse. Radiographic cam lesions in patients presenting with unilateral SCFE were only seen in patients who did not have prophylactic fixation. Furthermore, prophylactic fixation of the contralateral hip was found to be a cost-effective procedure, with a cost per quality adjusted life year gained of £1431 at the time of last follow-up.Prophylactic fixation of the contralateral hip is a cost-effective operation that limits the morbidity from the complications of a further slip, and the diminished functional outcome associated with unilateral fixation.Cite this article: Bone Joint J 2015;97-B:1428–34.
Quantification of material loss from the neck piece taper junctions of a bimodular primary hip prosthesis. A retrieval study from 27 failed Rejuvenate bimodular hip arthroplasties
Authors: Buente D. , Huber G. , Bishop N. , Morlock M. 
Published: October 2015

The early failure and revision of bimodular primary total hip arthroplasty prostheses requires the identification of the risk factors for material loss and wear at the taper junctions through taper wear analysis. Deviations in taper geometries between revised and pristine modular neck tapers were determined using high resolution tactile measurements. A new algorithm was developed and validated to allow the quantitative analysis of material loss, complementing the standard visual inspection currently used. The algorithm was applied to a sample of 27 retrievals (in situ from 2.9 to 38.1 months) of the withdrawn Rejuvenate modular prosthesis. The mean wear volumes on the flat distal neck piece taper was 3.35 mm3 (0.55 to 7.57), mainly occurring in a characteristic pattern in areas with high mechanical loading. Wear volume tended to increase with time to revision (r² = 0.423, p = 0.001). Implant and patient specific data (offset, stem size, patient’s mass, age and body mass index) did not correlate with the amount of material loss observed (p > 0.078). Bilaterally revised implants showed higher amounts of combined total material loss and similar wear patterns on both sides. The consistent wear pattern found in this study has not been reported previously, suggesting that the device design and materials are associated with the failure of this prosthesis. Cite this article: Bone Joint J 2015;97-B:1350–7.
Ray amputation for the treatment of foot macrodactyly in children
Authors: Kim J. , Park J. W. , Hong S. W. , Jeong J. Y. , Gong H. S. , Baek G. H. 
Published: October 2015

Macrodactyly of the foot is a rare but disabling condition. We present the results of surgery on 18 feet of 16 patients, who underwent ray amputation and were followed-up for more than two years at a mean of 80 months (25 to 198). We radiologically measured the intermetatarsal width and forefoot area pre-operatively and at six weeks and two years after surgery. We also evaluated the clinical results using the Oxford Ankle Foot Questionnaire for children (OxAFQ-C) and the Questionnaire for Foot Macrodactyly. The intermetatarsal width and forefoot area ratios were significantly decreased after surgery. The mean OxAFQ-C score was 42 (16 to 57) pre-operatively, improving to 47 (5 to 60) at two years post-operatively (p = 0.021). The mean questionnaire for Foot Macrodactyly score two years after surgery was 8 (6 to 10). Ray amputation gave a measurable reduction in foot size with excellent functional results. For patients with metatarsal involvement, a motionless toe, or involvement of multiple digits, ray amputation is a clinically effective option which is acceptable to patients. Cite this article: Bone Joint J 2015;97-B:1364–9.