bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review on photocatalytic degradation of aromatic organoarsenic compounds in aqueous environment using nanomaterials
Authors: Emmanuel Stephen Sunday , Adesibikan Ademidun Adeola 
Published: August 2024

AbstractAromatic organoarsenic compounds (AOCs) have proven to be both a boon and a curse by boosting profit maximization in livestock production and at the same time contributing to the pollution of water bodies, the chief cornerstone of the ecosystem. Interestingly, photocatalytic degradation using nanomaterials has emerged as an effective method to mitigate AOC pollution. Thus, this study aims to review and analyze original research works directed toward the photocatalytic degradation of AOC in the aqueous environment. In this study, the photocatalytic degradation efficiency of various nanomaterials is investigated for different aromatic organoarsenic compounds. In addition, an empirical analysis was conducted on the impact of electron trapping and radical scavengers. Furthermore, photocatalytic degradation kinetics and mechanisms were pragmatically discussed. Also, recyclability, stability, and real‐life applicability were empirically evaluated. According to this review, most nanomaterial materials had maximal photocatalytic degradation efficiencies of >75% for most AOCs within an average time of 6–330 min. The radical scavenging study revealed that ●OH and O2● mechanistically play a major role in AOC degradation than electrons and holes. Additionally, it was shown that expended photocatalysts can be eluted mostly with H2O/NaOH and recycled up to 3–6 rounds with a degradation efficiency of >80% in most cases while maintaining their original structural integrity. This indicates that the method has the potential to be both environmentally friendly and industrially scalable. Ultimately, research gaps were highlighted, which can help researchers identify future research hotspots and open doors for technique advancement.
Frequency of rs1051338 and rs116928232 Variants in Individuals from Northwest Mexico
Authors: Hernández‐Orozco Angélica Alejandra , Melendez‐Aranda Lennon , Mendoza‐Ruvalcaba Sandra del Carmen , Perea‐Díaz Francisco Javier , Cebolla Jorge J. , Giraldo Pilar , Brambila‐Tapia Aniel Jessica Leticia , García‐Ortíz José Elías 
Published: August 2024

ABSTRACTBackgroundLIPA, situated on chromosome 10q23.2‐q23.3, encodes the enzyme lysosomal acid lipase (LAL) (EC 3.1.1.13). Genetic alterations in LIPA lead to lysosomal acid lipase deficiency (LALD), an inborn error causing lipid metabolism anomalies and impairing cholesterol and triacylglyceride degradation. Over 40 LIPA variants have been documented, yet this study focuses on just two. The rs1051338 variant (NM_000235:c.46A>C) affects the signal peptide in Exon 2, whereas rs116928232, located in Exon 8, alters the splice site (NM_000235:c.894G>A), impacting lysosomal acid lipase activity. Considering the diverse clinical manifestations of LALD and the rising hepatic steatosis prevalence in Mexican population, mainly due to diet, these variants were investigated within this demographic to uncover potential contributing factors. This study aimed to reveal the frequency of rs1051338 and rs116928232 among healthy mestizo individuals in Northwest Mexico, marking a significant genetic exploration in this demographic.MethodsThree hundred ten healthy mestizo individuals underwent PCR‐RFLP analysis for both variants, and Sanger sequencing was performed for variant rs116928232. Bioinformatic analysis was also performed to predict protein changes.ResultsAllele frequencies for rs1051338 (FA = 0.39, p value = 0.15) and rs116928232 (FA = 0.0016, p value = 0.49) aligned with reported data, while bioinformatic analysis allowed us to identify the protein alteration observed in both variants; finally, the variants showed no linkage between them (normalized D′ = 1.03, p value = 0.56).ConclusionsAllelic frequencies closely matched reported data, and protein structure analysis confirmed variant impacts on LAL enzyme function. Notably, this study marks the first analysis of rs1051338 and rs116928232 in a healthy Mexican mestizo population.
Non‐cell‐autonomous suppression of tumor growth by RECK in immunocompetent mice
Authors: Matsuzaki Tomoko , Inoue Joe , Minato Nagahiro , Noda Makoto 
Published: August 2024

AbstractRECK is a candidate tumor suppressor gene isolated as a gene that induces flat reversion in a cell line transformed by the KRAS oncogene. Since RECK knockout mice die in utero, they are not suitable for studying the effects of RECK on tumor formation. In this study, we found an increased incidence of spontaneous pulmonary adenomas in mice with reduced RECK expression (RECK‐Hypo mice). To evaluate the effects of RECK expressed by either tumor cells or host cells on tumor growth, we established a tumorigenic cell line (MKER) from the kidney of a C57BL/6 mouse and performed syngeneic transplantation experiments. Our results indicate that when RECK expression is low in host cells, transplanted MKER cells grow faster and kill the animal more rapidly. Since RECK is required for the formation of proper fibrillin fibers that serve as a tissue reservoir for precursors of TGFβ‐family cytokines, we assessed the levels of TGFβ1 in the peripheral blood. We found a significant increase in TGFβ1 in RECK‐Hypo mice compared to wild‐type mice. We also found that the proportion of FOXP3‐positive regulatory T (Treg) cells among splenocytes was higher in RECK‐Hypo mice compared to the control mice. Furthermore, the number of FOXP3‐positive cells in spontaneous hematopoietic neoplasms in the lungs as well as tumors that formed after MKER transplantation was significantly higher in RECK‐Hypo mice compared to the control mice. These findings indicate that RECK‐mediated tumor suppression involves a non‐cell‐autonomous mechanism and that possible roles of TGFβ1 and Treg cells in such a mechanism warrant further study.
Expression of the αVβ3 integrin affects prostate cancer sEV cargo and density and promotes sEV pro‐tumorigenic activity in vivo through a GPI‐anchored receptor, NgR2
Authors: Verrillo Cecilia E. , Quaglia Fabio , Shields Christopher D. , Lin Stephen , Kossenkov Andrew V. , Tang Hsin‐Yao , Speicher David , Naranjo Nicole M. , Testa Anna , Kelly William K. , Liu Qin , Leiby Benjamin , Musante Luca , Sossey‐Alaoui Khalid , Dogra Navneet , Chen Tzu‐Yi , Altieri Dario C. , Languino Lucia R. 
Published: August 2024

AbstractIt is known that small extracellular vesicles (sEVs) are released from cancer cells and contribute to cancer progression via crosstalk with recipient cells. We have previously reported that sEVs expressing the αVβ3 integrin, a protein upregulated in aggressive neuroendocrine prostate cancer (NEPrCa), contribute to neuroendocrine differentiation (NED) in recipient cells. Here, we examine the impact of αVβ3 expression on sEV protein content, density and function. sEVs used in this study were isolated by iodixanol density gradients and characterized by nanoparticle tracking analysis, immunoblotting and single vesicle analysis. Our proteomic profile of sEVs containing αVβ3 shows downregulation of typical effectors involved in apoptosis and necrosis and an upregulation of tumour cell survival factors compared to control sEVs. We also show that the expression of αVβ3 in sEVs causes a distinct reposition of EV markers (Alix, CD81, CD9) to a low‐density sEV subpopulation. This low‐density reposition is independent of extracellular matrix (ECM) protein interactions with sEVs. This sEV subset contains αVβ3 and an αVβ3 downstream effector, NgR2, a novel marker for NEPrCa. We show that sEVs containing αVβ3 are loaded with higher amounts of NgR2 as compared to sEVs that do not express αVβ3. Mechanistically, we demonstrate that sEVs containing NgR2 do not affect the sEV marker profile, but when injected in vivo intratumorally, they promote tumour growth and induce NED. We show that sEVs expressing NgR2 increase the activation of focal adhesion kinase (FAK), a known promoter of cancer cell proliferation, in recipient cells. We also show that NgR2 mimics the effect of sEVs containing αVβ3 since it displays increased growth of NgR2 transfectants in vivo, as compared to control cells. Overall, our results describe the changes that occur in cargo, density and functions of cancer cell‐derived sEVs containing the αVβ3 integrin and its effector, NgR2, without affecting the sEV tetraspanin profiles.
Stability of Rose Window graphs
Authors: Ahanjideh Milad , Kovács István , Kutnar Klavdija 
Published: August 2024

AbstractA graph is said to be stable if for the direct product is isomorphic to ; otherwise, it is called unstable. An unstable graph is called nontrivially unstable when it is not bipartite and no two vertices have the same neighborhood. Wilson described nine families of unstable Rose Window graphs and conjectured that these contain all nontrivially unstable Rose Window graphs (2008). In this paper we show that the conjecture is true.
Toward precision medical education: Characterizing individual residents' clinical experiences throughout training
Authors: Drake Carolyn B. , Rhee David W. , Panigrahy Neha , Heery Lauren , Iturrate Eduardo , Stern David T. , Sartori Daniel J. 
Published: August 2024

AbstractBackgroundDespite the central role of experiential learning in residency training, the actual clinical experiences residents participate in are not well characterized. A better understanding of the type, volume, and variation in residents' clinical experiences is essential to support precision medical education strategies.ObjectiveWe sought to characterize the entirety of the clinical experiences had by individual internal medicine residents throughout their time in training.MethodWe evaluated the clinical experiences of medicine residents (n = 51) who completed training at NYU Grossman School of Medicine's Brooklyn campus between 2020 and 2023. Residents' inpatient and outpatient experiences were identified using notes written, orders placed, and care team sign‐ins; principal ICD‐10 codes for each encounter were converted into medical content categories using a previously described crosswalk tool.ResultsOf 152,426 clinical encounters with available ICD‐10 codes, 132,284 were mapped to medical content categories (94.5% capture). Residents' clinical experiences were particularly enriched in infectious and cardiovascular disease; most had very little exposure to allergy, dermatology, oncology, or rheumatology. Some trainees saw twice as many cases in a given content area as did others. There was little concordance between actual frequency of clinical experience and expected content frequency on the ABIM certification exam.ConclusionsIndividual residents' clinical experiences in training vary widely, both in number and in type. Characterizing these experiences paves the way for exploration of the relationships between clinical exposure and educational outcomes, and for the implementation of precision education strategies that could fill residents' experiential gaps and complement strengths with targeted educational interventions.
Neurodevelopmental profiles of 14 individuals with phosphomannomutase deficiency (PMM2‐CDG)
Authors: Weixel Tara , Adedipe Dee , Muldoon Glennis , Lam Christina , Krasnewich Donna , Thurm Audrey , Wolfe Lynne 
Published: August 2024

AbstractPMM2‐CDG (formerly CDG‐1a), the most common type of congenital disorders of glycosylation, is inherited in an autosomal recessive pattern. PMM2‐CDG frequently presents in infancy with multisystemic clinical involvement, and it has been diagnosed in over 1000 people worldwide. There have been few natural history studies reporting neurodevelopmental characterization of PMM2‐CDG. Thus, a prospective study was conducted that included neurodevelopmental assessments as part of deep phenotyping. This study, Clinical and Basic Investigations into Known and Suspected Congenital Disorders of Glycosylation (NCT02089789), included 14 participants (8 males and 6 females ages 2–33 years) with a confirmed molecular diagnosis of PMM2‐CDG. Clinical features of PMM2‐CDG in this cohort were neurodevelopmental disorders, faltering growth, hypotonia, cerebellar atrophy, peripheral neuropathy, movement disorders, ophthalmological abnormalities, and auditory function differences. All PMM2‐CDG participants met criteria for intellectual disability (or global developmental delay if younger than age 5). The majority never attained certain gross motor and language milestones. Only two participants were ambulatory, and almost all were considered minimally verbal. Overall, individuals with PMM2‐CDG present with a complex neurodevelopmental profile characterized by intellectual disability and multisystemic presentations. This systematic quantification of the neurodevelopmental profile of PMM2‐CDG expands our understanding of the range in impairments associated with PMM2‐CDG and will help guide management strategies.
Comprehensive characterization of a high‐performance double heterojunction InGaAs pHEMT for linear power‐efficient amplifiers applications
Authors: Sultana Sadia , Naima Jannatul , Alam Md. Shamsul , Alam Md. Shah , Crupi Giovanni , Alim Mohammad A. 
Published: August 2024

AbstractThis article centers its attention on the phenomenon of electrostatics, linearity, analogue, and RF performance of a 0.5 μm × (2 × 100) μm double heterojunction AlGaAs/InGaAs/GaAs pHEMT using on‐wafer DC and RF measurements up to 50 GHz. With a high ION/IOFF ratio (1.21 × 107) and low subthreshold slope (72.7 mV/dec), a flat and high transconductance over a wide range of Vgs has been achieved for the tested device. Furthermore, the input intercept and higher‐order voltage intercept point both attained large values with low intermodulation and harmonic distortion. Regarding RF parameters, the intrinsic gain has been achieved up to 28 dB. The GBW up to 750 GHz was attained, with the highest fT and fmax values being 24.5 GHz and 99.3 GHz, respectively. Since the device has very low intrinsic capacitance, parameters like TFP, GFP, and GTFP also showed excellent results. The high intrinsic gain and TGF indicate ample potential of the device for use as an amplifier. Investigating the parameters reveals the device to have very good linearity and amplifying capability.
A multimethod investigation of the interpersonal effects of leader perfectionism and anger expression on employee psychological safety and creativity
Authors: Ocampo Anna Carmella G. , Gu Jun , Li Quan , Koseoglu Gamze , Wang Lu , Ashkanasy Neal M. 
Published: August 2024

SummaryHeightened competition within and across organizations compels leaders to set inflexibly high standards and to demand creative performance from their employees. Considering recent research on the interpersonal approach to perfectionism and anger expression, we predicted that leaders' perfectionism combined with their anger expression would threaten employees' psychological safety and creative effort that, in turn, would diminish their creative performance. To test our predictions, we designed three multimethod studies: (1) a preregistered memory reconstruction study, (2) a preregistered laboratory experiment, and (3) a multi‐wave and multi‐source field study. We found convergent evidence that leaders' anger expressions exacerbate the negative indirect influence of their perfectionism on employees' creative performance via psychological safety and creative effort. We conclude by discussing the interpersonal consequences of leader perfectionism in the workplace.
Soluble hemp protein–xylose conjugates fabricated by high‐pressure homogenization and pH‐shifting treatments
Authors: Karabulut Gulsah , Kapoor Ragya , Feng Hao 
Published: August 2024

AbstractBACKGROUNDThe process of Maillard conjugation occurs with plant proteins and sugars and can be influenced by several factors, such as processing time, pH, and shear force. By utilizing cavitation processes such as high‐pressure homogenization (HPH) and pH‐shifting, it is possible to regulate the degree of grafting, functional characteristics, and structural changes in the formation of conjugates. The present study aimed to improve the hemp protein concentrate (HPC) through two different conjugation techniques: HPH and pH‐shifting‐assisted processes.RESULTSThe best conjugation conditions for the conventional method were identified as a 1:2 HPC to xylose ratio, a pH of 10, and 3 h of treatment at 70 °C. The use of HPH and pH 12‐shifting methods resulted in a remarkable 2.5‐fold increase in grafting degree, requiring less processing time. Fourier transform infrared spectra confirmed the formation of conjugates. Conjugates produced through HPH with pH 12‐shifting (MPHX) transformed into soluble glycoproteins with a particle size of 74 nm. MPHX solubility increased by 5.7‐fold than HPC, reaching 85.7%, with a more negatively charged surface at −32.4 mV. Microimages showed cracked and sharp forms for conjugated proteins compared to untreated HPC. Additionally, MPHX conjugates demonstrated superior properties in emulsion stability, foaming capacity, and antioxidant activity compared to HPC and classical conjugates.CONCLUSIONThe use of HPH and pH‐shifting‐assisted Maillard conjugation was highly effective in enhancing the functional attributes of hemp protein conjugates. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Habitat selection of non‐breeding American black ducks in an urban estuary
Authors: Mezebish Quinn Tori , Paton Peter W. , Gerber Brian D. , Kilburn Jennifer E. , McWilliams Scott R. 
Published: August 2024

AbstractShellfish aquaculture is a globally expanding industry, including in urban estuaries that support non‐breeding waterfowl. The effects of shellfish aquaculture on the spatial distribution of non‐breeding waterfowl, however, are poorly understood and depend on the ecology of waterfowl and cultivated shellfish species. We investigated how proximity to shellfish aquaculture influenced habitat selection and movement patterns of American black ducks (Anas rubripes) during the non‐breeding season (~Oct–May) in 2020–2023 in Rhode Island, USA. The extent to which proximity to aquaculture influenced habitat selection of black ducks depended on factors specific to individuals' primary non‐breeding sites, although proximity to aquaculture did not have biologically meaningful influences on black duck movement rates across all sites. Black ducks across sites consistently selected for areas better suited for aquaculture (i.e., areas of potential future development) relative to areas poorly suited for aquaculture (i.e., areas less likely to be developed). The continued expansion of aquaculture into preferred black duck habitats will increase black duck interactions with aquaculture and therefore should be considered in the decision‐making process for siting future aquaculture leases. Future studies should quantify the extent to which continued expansion of aquaculture in those preferred coastal habitats directly influences black ducks.
A modified arthroscopic en masse suture bridge repair is effective for delaminated rotator cuff tears
Authors: Fang Sheng , Wang Xianfeng , Xu Peng , Sun Han , Jiang Zhecheng , Yan Litao , Wang Yiming , Liu Jinbo , Li Huan 
Published: August 2024

AbstractPurposeThis study aimed to clarify the characteristics of delaminated rotator cuff tears (RCTs) and evaluate the clinical outcomes of a modified arthroscopic en masse suture bridge repair for delaminated RCTs.MethodsPatients with full‐thickness RCTs, who underwent arthroscopic suture bridge repair with a minimum 2‐year follow‐up, were retrospectively reviewed. Patients were categorized into two groups based on the presence of delamination. Delaminated RCTs were treated using a modified en masse suture bridge technique, while nondelaminated RCTs received a conventional suture bridge technique. Preoperative and postoperative Constant scores and American Shoulder and Elbow Surgeons (ASES) scores were determined to evaluate clinical outcomes. Postoperative magnetic resonance imaging (MRI) was carried out to identify the integrity and retear of the repaired rotator cuff.ResultsA total of 172 patients were included in our study cohort, in which 67 (39%) delaminated RCTs were confirmed intraoperatively. The prevalence of delamination was significantly higher in large tears (53/102, 52%) compared to medium tears (14/70, 20%) (p < 0.001). No significant differences in age (n.s.) or gender (n.s.) were observed between the two groups. Both groups showed significant improvements in Constant and ASES scores postoperatively (both p < 0.001), with no significant differences between the groups (n.s.). The retear rates were 2/67 (3.0%) in the delamination group and 3/105 (2.9%) in the nondelamination group, showing no significant difference (n.s.).ConclusionsThe modified arthroscopic en masse suture bridge technique was effective for repairing delaminated RCTs, yielding favourable clinical outcomes comparable to those of nondelaminated tears.Level of EvidenceLevel IV.
Effects of current intensities on material removal rate, electrode wear rate, and surface roughness of machining high carbon high chromium steel
Authors: Rakesh P. K. , Gupta M. K. , Mahto J. N. , Rajput N. S. 
Published: August 2024

AbstractThe electrical discharge machining is very successful and generally recognized for producing complicated shapes and small openings with exceptional precision. The objective of this study is to assess the impact of different electrical discharge machining parameters on the attributes of the machining process. The evaluation of the machining process was conducted based on the workpiece‘s material removal rate, the rate at which the electrodes wear, and the level of surface roughness. Simultaneously achieving a high material removal rate, low electrode wear rate, and high surface roughness is not possible with a specific combination of approaches due to their contradicting nature. Frequently, it is necessary to independently apply many measures instantaneously in order to assess their impact on various responses. This research investigates the machining of high carbon high chromium steel making use of electrical discharge machining with aluminum, copper, and graphite electrodes. The study focuses on the impact of different current intensities on the rate of material removal, electrode wear, and surface roughness. The experimental results demonstrate that the highest material removal rate (mmcubicmin−1) is achieved at a current density of 12 A when using a copper electrode (54.67), as opposed to aluminum electrode (22.91) and graphite electrode (29.43).