bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chapter 26 Consequences of long-term volcanic activity for essential services in Montserrat: challenges, adaptations and resilience
Authors: Sword-Daniels V. , Wilson T. M. , Sargeant S. , Rossetto T. , Twigg J. , Johnston D. M. , Loughlin S. C. , Cole P. D. 
Published: June 2014

Abstract
Long-term volcanic activity at Soufrière Hills Volcano (SHV), Montserrat (1995–ongoing) has created challenges for society and the resilience of the essential services (infrastructure) that support it. This paper explores the consequences, adaptations and resilience of essential services through interviews with their staff. We find that quick fixes for essential service reinstatement in the north of Montserrat have prevailed. Yet, the legacy of this approach inhibits functionality through inadequate facilities and the perception of sites as temporary, stalling investment. Emigration resulted in staff shortages, retraining requirements and challenges for the viability of specialist services. Low-impact hazards exacerbate shortcomings in essential services, causing power cuts, corrosion, and temporary closures of schools, clinics and the airport. Adaptations developed over time include changes to roofing materials, the addition of back-up systems, collaborative working and the development of contingency plans. Resilience of essential services has improved through decentralization, adaptations, and via strong community networks and tolerance of disruptions. Barriers to increasing resilience include the expense of some adaptations and the current reluctance to invest in essential services, hindering development. We offer some lessons for policy and practice to guide post-crisis redevelopment, through engagement with the community and by complementing community-level adaptations with investment to address long-term needs.
Chapter 3 Dual-chamber-conduit models of non-linear dynamics behaviour at Soufrière Hills Volcano, Montserrat
Authors: Melnik Oleg , Costa Antonio 
Published: June 2014

Abstract
Modern geophysical data recorded during lava dome building eruptions indicate the presence of multiple connected magma storage regions. Most numerical models for lava dome eruptions assume a single magma chamber fed from below with a constant or prescribed time dependent influx rate and connected to the Earth surface through a conduit.
Here we present a development of the model of extrusive eruptions considering a system made of two magma chambers located in elastic rocks and connected by a dyke between each other. We use locations and volumes of the magma chambers inferred for Soufrière Hills Volcano, Montserrat from ground deformation studies and seismic tomography.
The model shows cyclic behaviour with a period that depends on the intensity of the influx rate, the volumes and shape of the two chambers and the degree of connectivity of the two reservoirs. For a weak connectivity the overpressure in the lower chamber stays nearly constant during the cycle and the influx of fresh magma into the shallow chamber is also nearly constant. For a strong connectivity between the chambers their overpressure increases or decreases during the cycle in a synchronous way.
Chapter 4 Ash venting occurring both prior to and during lava extrusion at Soufrière Hills Volcano, Montserrat, from 2005 to 2010
Authors: Cole P. D. , Smith P. , Komorowski J.-C. , Alfano F. , Bonadonna C. , Stinton A. , Christopher T. , Odbert H. M. , Loughlin S. 
Published: June 2014

Abstract
This paper describes ash-venting activity at Soufrière Hills Volcano, Montserrat that was precursory to the onset of three phases of lava extrusion in 2005, 2008 and 2009, and similar ash venting that occurred during the fifth phase of lava extrusion.
We describe in detail a style of mild, tephra-generating activity termed ash venting and its associated tephra products. The nature of the seismicity associated with ash venting is compared with that of explosive activity. All explosive events, from small explosions to large Vulcanian explosions, have impulsive, low-frequency onsets. These are absent in ash-venting events, which have subtle, emergent onsets.
Microscope and grain-size analyses show that ash-venting events and large Vulcanian explosions generate tephra that is similar in grain size (in medial and distal regions), although phreatic events in 2005 were finer grained. Ash-venting products are either composed of fine-grained, variably altered pre-existing material or juvenile material. There is a general correlation between the length of the pause and the length of the period of precursory activity prior to lava extrusion following it. Syn-extrusive ash venting is frequently associated with short-term increases in extrusion rate and is considered to be related to shear-induced fragmentation at the conduit margin.
Chapter 9 Thermal, acoustic and seismic signals from pyroclastic density currents and Vulcanian explosions at Soufrière Hills Volcano, Montserrat
Authors: Delle Donne D. , Ripepe M. , De Angelis S. , Cole P. D. , Lacanna G. , Poggi P. , Stewart R. 
Published: June 2014

Abstract

We show two examples of how integrated analysis of thermal and infrasound signal can be used to obtain, in real time, information on volcanic activity. Soufrière Hills Volcano (SHV) on Montserrat offers the opportunity to study a large variety of processes related to lava-dome activity, such as pyroclastic density currents (PDCs) and large Vulcanian eruptions. Infrasound and thermal analysis are used to constrain the propagation of PDCs and their velocities, which are calculated here to range between 15 and 75 m s
−1
. During the Vulcanian eruption of 5 February 2010, infrasound and thermal records allow us to identify an approximately 13 s seismic precursor possibly related to the pressurization of the conduit before the explosion onset. The associated very long period (VLP) seismic signal is correlated with the gas-thrust phase detected by thermal imagery, and may reflect a change in the upward momentum induced by the mass discharge. Moreover, from infrasound and thermal analysis, we estimate a gas-thrust phase lasting 22 s, with an initial plume velocity of approximately 170 m s
−1
and a mean volumetric discharge rate of 0.3×10
5
–9.2×10
5
m
3
s
−1
. This information provided in real time gives important input parameters for modelling the tephra dispersal into the atmosphere.
VEGFA Genomic Amplification Tailors Treatment of HCCs with Sorafenib
Authors: Luo Xiaolin , Feng Gen-Sheng 
Published: June 2014

Abstract
Summary: In this issue of Cancer Discovery, Horwitz and colleagues identified a subtype of hepatocelluar carcinoma (HCC) bearing VEGFA genomic amplification that is particularly sensitive to VEGFA inhibition and is also more sensitive to sorafenib treatment. Taken conjointly, these data suggest that VEGFA genomic amplification can be used as a biomarker for personalized treatment of HCC with sorafenib. Cancer Discov; 4(6); 640–1. ©2014 AACR.
See related article by Horwitz et al., p. 730
Wave Measurement Intercomparison and Platform Evaluation during the ITOP (2010) Experiment
Authors: Collins Clarence O. , Lund Björn , Ramos Rafael J. , Drennan William M. , Graber Hans C. 
Published: June 2014

Abstract
Spectral wave parameters from 11 platforms, measured during the recent Impact of Typhoons on the Ocean in the Pacific (ITOP) experiment, are intercompared. Two moorings, separated by ~180 km, were deployed in a section of “typhoon alley” off the coast of Taiwan for 4 months. Each mooring consisted of an Air–Sea Interaction Spar (ASIS) buoy that was tethered to a moored Extreme Air–Sea Interaction (EASI) buoy. EASI, the design of which is based on the hull of a 6-m Navy Oceanographic Meteorological Automatic Device (NOMAD) buoy, is validated as a 1D wave sensor against the established ASIS. Also, during this time three drifting miniature wave buoys, a wave-measuring marine radar on the Research Vessel Roger Revelle, and several overpasses of Jason-1 (C and Ku bands) and Jason-2 (Ku band) satellite altimeters were within 100 km of either the northern or southern mooring site. These additional measurements were compared against both EASI buoys. Findings are in-line with previous wave parameter intercomparisons. A corroborated measurement of mean wave direction and direction at the peak of the spectrum from the EASI buoy is presented. Consequently, this study is the first published account of directional wave information that has been successfully gathered from a buoy with a 6-m NOMAD-type hull. This result may be applied to improve operational coverage of wave direction. A high level of confidence is established in the ITOP wave data. Advantages and disadvantages of the different sensor types are discussed, which may be useful for the design of future field experiments.
Ocean Data Impacts in Global HYCOM*
Authors: Cummings James A. , Smedstad Ole Martin 
Published: June 2014

Abstract
The impact of the assimilation of ocean observations on reducing global Hybrid Coordinate Ocean Model (HYCOM) 48-h forecast errors is presented. The assessment uses an adjoint-based data impact procedure that characterizes the forecast impact of every observation assimilated, and it allows the observation impacts to be partitioned by data type, geographic region, and vertical level. The impact cost function is the difference between HYCOM 48- and 72-h forecast errors computed for temperature and salinity at all model levels and grid points. It is shown that routine assimilation of large numbers of observations consistently reduces global HYCOM 48-h forecast errors for both temperature and salinity. The largest error reduction is due to the assimilation of temperature and salinity profiles from the tropical fixed mooring arrays, followed by Argo, expendable bathythermograph (XBT), and animal sensor data. On a per-observation basis, the most important global observing system is Argo. The beneficial impact of assimilating Argo temperature and salinity profiles extends to all depths sampled, with salinity impacts maximum at the surface and temperature impacts showing a subsurface maximum in the 100–200-m-depth range. The reduced impact of near-surface Argo temperature profile levels is due to the vertical covariances in the assimilation that extend the influence of the large number of sea surface temperature (SST) observations to the base of the mixed layer. Application of the adjoint-based data impact system to identify a data quality problem in a geostationary satellite SST observing system is also provided.
Observations of the Eyewall Structure of Typhoon Sinlaku (2008) during the Transformation Stage of Extratropical Transition
Authors: Foerster Annette M. , Bell Michael M. , Harr Patrick A. , Jones Sarah C. 
Published: June 2014

AbstractA unique dataset observing the life cycle of Typhoon Sinlaku was collected during The Observing System Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaign (T-PARC) in 2008. In this study observations of the transformation stage of the extratropical transition of Sinlaku are analyzed. Research flights with the Naval Research Laboratory P-3 and the U.S. Air Force WC-130 aircraft were conducted in the core region of Sinlaku. Data from the Electra Doppler Radar (ELDORA), dropsondes, aircraft flight level, and satellite atmospheric motion vectors were analyzed with the recently developed Spline Analysis at Mesoscale Utilizing Radar and Aircraft Instrumentation (SAMURAI) software with a 1-km horizontal- and 0.5-km vertical-node spacing. The SAMURAI analysis shows marked asymmetries in the structure of the core region in the radar reflectivity and three-dimensional wind field. The highest radar reflectivities were found in the left of shear semicircle, and maximum ascent was found in the downshear left quadrant. Initial radar echos were found slightly upstream of the downshear direction and downdrafts were primarily located in the upshear semicircle, suggesting that individual cells in Sinlaku’s eyewall formed in the downshear region, matured as they traveled downstream, and decayed in the upshear region. The observed structure is consistent with previous studies of tropical cyclones in vertical wind shear, suggesting that the eyewall convection is primarily shaped by increased vertical wind shear during step 2 of the transformation stage, as was hypothesized by Klein et al. A transition from active convection upwind to stratiform precipitation downwind is similar to that found in the principal rainband of more intense tropical cyclones.
A discussion on generalized almost contractions via rational expressions in partially ordered metric spaces
Authors: Mustafa Zead , Karapınar Erdal , Aydi Hassen 
Published: June 2014

Abstract
The main purpose of this paper is to give some fixed point results for mappings involving generalized

(
ϕ
,
ψ
)

-contractions in partially ordered metric spaces. Our results generalize, extend, and unify several well-known comparable results in the literature (Jaggi in Indian J. Pure Appl. Math. 8(2):223-230, 1977, Harjani et al. in Nonlinear Anal. 71:3403-3410, 2009, Luong and Thuan in Fixed Point Theory Appl. 2011:46, 2011). The presented results are supported by three illustrative examples.

MSC: 46N40, 47H10, 54H25, 46T99.
Is a single item stress measure independently associated with subsequent severe injury: a prospective cohort study of 16,385 forest industry employees
Authors: Salminen Simo , Kouvonen Anne , Koskinen Aki , Joensuu Matti , Väänänen Ari 
Published: June 2014

Abstract

Background
A previous review showed that high stress increases the risk of occupational injury by three- to five-fold. However, most of the prior studies have relied on short follow-ups. In this prospective cohort study we examined the effect of stress on recorded hospitalised injuries in an 8-year follow-up.

Methods
A total of 16,385 employees of a Finnish forest company responded to the questionnaire. Perceived stress was measured with a validated single-item measure, and analysed in relation recorded hospitalised injuries from 1986 to 2008. We used Cox proportional hazard regression models to examine the prospective associations between work stress, injuries and confounding factors.

Results
Highly stressed participants were approximately 40% more likely to be hospitalised due to injury over the follow-up period than participants with low stress. This association remained significant after adjustment for age, gender, marital status, occupational status, educational level, and physical work environment.

Conclusions
High stress is associated with an increased risk of severe injury.
Elevated serum CA19-9 level is a promising predictor for poor prognosis in patients with resectable pancreatic ductal adenocarcinoma: a pilot study
Authors: Dong Qian , Yang Xiang-hong , Zhang Yao , Jing Wei , Zheng Li-qiang , Liu Yun-peng , Qu Xiu-juan 
Published: June 2014

Abstract

Background
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human cancers. Several studies have reported that the carbohydrate antigen 19-9 (CA19-9) level is a useful marker for predicting the prognosis for PDAC after resection. However, the cutoff value of CA19-9 used to predict prognosis varied among these reports. The aims of this study were to evaluate whether the serum CA19-9 level is a significant predictor for survival and to determine the optimal cutoff value of CA19-9 for predicting prognosis.

Methods
A total of 120 consecutive patients who underwent surgery for potentially resectable primary PDAC were retrospectively analyzed. The variables included the following: age, sex, the location of the tumor, the maximal tumor size, the histological differentiation, the margin status, the tumor stage, serum CA19-9 levels, and serum total bilirubin (TBil) levels.

Results
The overall 1-year survival rate was 62.5%. The receiver operating characteristic (ROC) curve indicated a significant result for the level of CA19-9 in predicting death within 1 year after surgery (Area under the curve (AUC), 0.612; 95% confidence interval (CI), 0.505-0.720; P = 0.040). The optimal cutoff point was 338.45 U/mL (sensitivity, 60.0%; specificity, 66.7%; accuracy, 64.2%). The strongest univariate predictor among the categorized CA19-9 values was CA19-9 greater than or equal to 338.45 U/mL. In the multivariate Cox proportional hazards mode analysis, the serum CA19-9 level, age and the histological differentiation were significant independent prognostic factors that were associated with the overall survival.

Conclusions
The preoperative elevated CA19-9 level is a promising independent factor for predicting a poor prognosis in PDAC, and the optimal cutoff value is 338.45 U/mL.
Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
Authors: Feinberg Hadar , Saldanha José W , Diep Linnea , Goel Amita , Widom Angela , Veldman Geertruida M , Weis William I , Schenk Dale , Basi Guriqbal S 
Published: June 2014

Abstract
Introduction
Immunotherapy targeting amyloid-β peptide is under active clinical investigation for treatment of Alzheimer’s disease (AD). Among the hypotheses being investigated for impact on clinical outcome are the preferred epitope or conformation of amyloid-β to target for treatment, and the mechanism of action underlying immunotherapy. Bapineuzumab (humanized 3D6), a neo-epitope specific antibody recognizing amyloid-β1-5 with strong preference for an exposed Asp residue at the N-terminus of the peptide, has undergone advanced clinical testing for treatment of AD.

Methods
To gain further insight into the epitope conformation, we interrogated structural details of amino-terminal epitopes in amyloid-β using x-ray crystallography of 3D6Fab:amyloid-β complexes. Humanization of 3D6 was carried out using standard procedures integrating recombinant methods, sequence informatics, and homology modeling predictions to identify important mouse framework residues for retention in the finished humanized product.

Results
Here we report the crystal structure of a recombinant Fab fragment of 3D6 in complex with amyloid-β1-7 solved at 2.0 Å resolution. The N-terminus of amyloid-β is bound to 3D6 as a 310 helix. The amino-terminal Asp residue is buried deepest in the antibody binding pocket, with the Cβ atom of residue 6 visible at the entrance to the binding pocket near the surface of the antibody. We further evaluate homology model based predictions used to guide humanization of 3D6 to bapineuzumab, with actual structure of the Fab. The structure of the Fab:amyloid-β complex validates design of the humanized antibody, and confirms the amyloid-β epitope recognized by 3D6 as previously mapped by ELISA.

Conclusions
The conformation of amyloid-β antigen recognized by 3D6 is novel and distinct from other antibodies recognizing N-terminal epitopes. Our result provides the first report demonstrating structural conservation of antigen contact residues, and conformation of antigen recognized, between the parent murine antibody and its humanized version.
The role of CXCL10 in the pathogenesis of experimental septic shock
Authors: Herzig Daniela S , Luan Liming , Bohannon Julia K , Toliver-Kinsky Tracy E , Guo Yin , Sherwood Edward R 
Published: June 2014

Abstract
Introduction
The chemokine CXCL10 is produced during infection and inflammation to activate the chemokine receptor CXCR3, an important regulator of lymphocyte trafficking and activation. The goal of this study was to assess the contributions of CXCL10 to the pathogenesis of experimental septic shock in mice.

Methods
Septic shock was induced by cecal ligation and puncture (CLP) in mice resuscitated with lactated Ringer’s solution and, in some cases, the broad spectrum antibiotic Primaxin. Studies were performed in CXCL10 knockout mice and mice treated with anti-CXCL10 immunoglobulin G (IgG). Endpoints included leukocyte trafficking and activation, core body temperature, plasma cytokine concentrations, bacterial clearance and survival.

Results
CXCL10 was present at high concentrations in plasma and peritoneal cavity during CLP-induced septic shock. Survival was significantly improved in CXCL10 knockout (CXCL10KO) mice and mice treated with anti-CXCL10 IgG compared to controls. CXCL10KO mice and mice treated with anti-CXCL10 IgG showed attenuated hypothermia, lower concentrations of interleukin-6 (IL-6) and macrophage inhibitory protein-2 (MIP-2) in plasma and lessened natural killer (NK) cell activation compared to control mice. Compared to control mice, bacterial burden in blood and lungs was lower in CXCL10-deficient mice but not in mice treated with anti-CXCL10 IgG. Treatment of mice with anti-CXCL10 IgG plus fluids and Primaxin at 2 or 6 hours after CLP significantly improved survival compared to mice treated with non-specific IgG under the same conditions.

Conclusions
CXCL10 plays a role in the pathogenesis of CLP-induced septic shock and could serve as a therapeutic target during the acute phase of septic shock.
Towards a more nuanced global mental health
Authors: White Ross G. , Sashidharan S. P. 
Published: June 2014

SummaryThe World Health Organization has made concerted efforts to scale up mental health services in low- and middle-income countries through the Mental Health Gap Action Programme (mhGAP) initiative. However, an overreliance on scaling up services based on those used in high-income countries may risk causing more harm than good.
Reported child awareness of parental depression
Authors: Eyre Olga , Jones Rhys Bevan , Mars Becky , Hammerton Gemma , Sellers Ruth , Potter Robert , Thapar Ajay , Rice Frances , Collishaw Stephan , Thapar Anita 
Published: June 2014

Aims and methodTo determine rates of parent-reported child awareness of parental depression, examine characteristics of parents, children and families according to child awareness, and explore whether child awareness is associated with child psychopathology. Data were available from 271 families participating in the Early Prediction of Adolescent Depression (EPAD) study, a longitudinal study of offspring of parents with recurrent depression.ResultsSeventy-three per cent of participating children were perceived as being aware of their parent's depression. Older children, and children of parents who experienced more severe depression, were more likely to be aware. Awareness was not associated with child psychopathology.Clinical implicationsConsidering children in the context of parental depression is important. Child awareness may influence their access to early intervention and prevention programmes. Further research is needed to understand the impact of awareness on the child.
Methodological Peculiarities of Marketing Researches related to High-Tech Production Market (Evidence from the Market of Mobile Devices)
Authors: Логвинов  , Logvinov Syergyey 
Published: June 2014

Peculiarities of high-tech production’s system marketing research based on
mathematical models, ones’ parameters have been determined using
multidimensional statistical analysis methods are considered. The cluster and
discriminant analysis have been taken as a basis. Selection of goods by
consumers depending on firm-manufacturer, set of goods’ technical
characteristics, as well as of consumers’ social, personal and psychological
characteristics are studied and modeled. A group of University’s students and
graduates is investigated as a segment of consumer market.