bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphisms of cell cycle control genes influence the development of sporadic medullary thyroid carcinoma
Authors: Barbieri R B , Bufalo N E , Secolin R , Assumpção L V M , Maciel R M B , Cerutti J M , Ward L S 
Published: November 2014

BackgroundThe role of key cell cycle regulation genes such as, CDKN1B, CDKN2A, CDKN2B, and CDKN2C in sporadic medullary thyroid carcinoma (s-MTC) is still largely unknown.MethodsIn order to evaluate the influence of inherited polymorphisms of these genes on the pathogenesis of s-MTC, we used TaqMan SNP genotyping to examine 45 s-MTC patients carefully matched with 98 controls.ResultsA multivariate logistic regression analysis demonstrated that CDKN1B and CDKN2A genes were related to s-MTC susceptibility. The rs2066827*GT+GG CDKN1B genotype was more frequent in s-MTC patients (62.22%) than in controls (40.21%), increasing the susceptibility to s-MTC (OR=2.47; 95% CI=1.048–5.833; P=0.038). By contrast, the rs11515*CG+GG of CDKN2A gene was more frequent in the controls (32.65%) than in patients (15.56%), reducing the risk for s-MTC (OR=0.174; 95% CI=0.048–0.627; P=0.0075). A stepwise regression analysis indicated that two genotypes together could explain 11% of the total s-MTC risk. In addition, a relationship was found between disease progression and the presence of alterations in the CDKN1A (rs1801270), CDKN2C (rs12885), and CDKN2B (rs1063192) genes. WT rs1801270 CDKN1A patients presented extrathyroidal tumor extension more frequently (92%) than polymorphic CDKN1A rs1801270 patients (50%; P=0.0376). Patients with the WT CDKN2C gene (rs12885) presented larger tumors (2.9±1.8 cm) than polymorphic patients (1.5±0.7 cm; P=0.0324). On the other hand, patients with the polymorphic CDKN2B gene (rs1063192) presented distant metastases (36.3%; P=0.0261).ConclusionIn summary, we demonstrated that CDKN1B and CDKN2A genes are associated with susceptibility, whereas the inherited genetic profile of CDKN1A, CDKN2B, and CDKN2C is associated with aggressive features of tumors. This study suggests that profiling cell cycle genes may help define the risk and characterize s-MTC aggressiveness.
Publication Trends in Model Organism Research
Authors: Dietrich Michael R , Ankeny Rachel A , Chen Patrick M 
Published: November 2014

AbstractIn 1990, the National Institutes of Health (NIH) gave some organisms special status as designated model organisms. This article documents publication trends for these NIH-designated model organisms over the past 40 years. We find that being designated a model organism by the NIH does not guarantee an increasing publication trend. An analysis of model and nonmodel organisms included in GENETICS since 1960 does reveal a sharp decline in the number of publications using nonmodel organisms yet no decline in the overall species diversity. We suggest that organisms with successful publication records tend to share critical characteristics, such as being well developed as standardized, experimental systems and being used by well-organized communities with good networks of exchange and methods of communication.
Measurements of the stratospheric Density and Temperature Profiles in Hanoi by a Rayleigh Lidar
Authors: Tuan Nguyen Xuan , Trung Dinh Van , Binh Nguyen Thanh , Hai Bui Van 
Published: November 2014

The molecular density and temperature profiles of the stratosphere in Hanoi are measured by a Rayleigh lidar. The profiles have the spatial resolution of 120 m and the temporal resolution of 1h. Their bottom height and top height are 20 km and 57 km, respectively. The atmospheric molecule density profile is directly derived from the correction-range lidar signal. The temperature profile is deduced from the molecular density profile based on the assumptions of the hydrostatic equilibrium and the ideal-gas law. Lidar measurements show good agreement with the molecular density and the temperature profiles from the MSISE-90 atmospheric model. Maximum errors of the density and temperature are found to be \(\pm 0.9\)\% and \(\pm 3.4\)~K, respectively.The position and the temperature of the stratopause in Hanoi are determined to be about 49 km and 270 K. Database of lidar in a long time might reveal the characteristic and the structure of the stratosphere in Hanoi, Vietnam.
A Phase II Trial of Capecitabine Concomitantly With Whole-Brain Radiotherapy Followed by Capecitabine and Sunitinib for Brain Metastases From Breast Cancer
Authors: Niravath Polly , Tham Yee Lu , Wang Tao , Rodriguez Angel , Foreman Claudette , Hilsenbeck Susan G. , Elledge Richard , Rimawi Mothaffar 
Published: November 2014

Abstract

Author Summary

Background.
Brain metastasis from breast cancer presents a significant threat to women's health and quality of life. Capecitabine and sunitinib have shown some activity in this setting; therefore, we conducted a single-arm phase II trial with these agents.

Methods.
Patients with breast cancer and central nervous system (CNS) metastases received whole-brain radiotherapy concurrently with capecitabine (1,000 mg/m2 per day for 14 consecutive days), followed by concomitant capecitabine (2,000 mg/m2 per day for 2 weeks followed by a 1-week break) and sunitinib (37.5 mg daily, continuously). The primary endpoint was progression-free survival (PFS).

Results.
Of 25 planned patients that would be required to detect a 4-month improvement (from 5 to 9 months) in median PFS with 80% power, 12 were enrolled, and the study was then closed for slow accrual. Median PFS was 4.7 months, and median overall survival was 10 months. In the CNS, 25% had progressive disease, and 83% experienced extra-CNS progression. The most common side effects were fatigue and nausea.

Conclusion.
In 12 evaluable patients studied, concurrent capecitabine and whole-brain radiation followed by capecitabine and sunitinib did not extend PFS over historical rates and was associated with significant toxicity. Our study was small and closed due to slow accrual.
A Mixed Methods Exploration of Family Involvement in Medical Care for Older Adults with Serious Mental Illness
Authors: Aschbrenner Kelly A. , Pepin Renee , Mueser Kim T. , Naslund John A. , Rolin Stephanie A. , Faber Marjan J. , Bartels Stephen J. 
Published: November 2014

Objective: Many older persons with serious mental illness (SMI) suffer from high rates of comorbid medical conditions. Although families play a critical role in psychiatric illness management among adults with SMI, their contributions to improving health outcomes in this population has received little attention. This study explored family involvement in medical care for older adults with SMI. Methods: This mixed methods study involved analysis of quantitative data collected from older adults with SMI and cardiovascular risk ( n = 28) participating in a pilot study of an intervention designed to improve patient-centered primary care augmented by qualitative interviews with their relatives ( n = 13) to explore family involvement in medical care. Results: Approximately 89% of older adults with SMI reported family involvement in at least one aspect of their medical care (e.g., medication reminders, medical decision making). However, many family members reported that they were rarely involved in their relative's medical visits, and most did not perceive a need to be involved during routine care. Family members identified obesity as their relative's primary health concern and many wanted guidance from providers on effective strategies for supporting weight loss. Conclusions: Although many family members did not perceive a need to be involved in their relative's routine medical visits, they expressed interest in talking with providers about how to help their relative change unhealthy behaviors. Educating patients, families, and providers about the potential benefits of family involvement in medical care, including routine medical visits for persons with SMI and cardiovascular health risk may promote patient- and family-centered collaboration in this high-risk population.
Pinning synchronization of the drive and response dynamical networks with lag
Authors: Wen Bohui , Zhao Mo , Meng Fanyu 
Published: November 2014

Abstract
This paper investigates the pinning synchronization of two general complex dynamical networks with lag. The coupling configuration matrices in the two networks are not need to be symmetric or irreducible. Several convenient and useful criteria for lag synchronization are obtained based on the lemma of Schur complement and the Lyapunov stability theory. Especially, the minimum number of controllers in pinning control can be easily obtained. At last, numerical simulations are provided to verify the effectiveness of the criteria
Tracking control of an underactuated rigid body with a coupling input force
Authors: Korczak Sebastian 
Published: November 2014

Abstract
This paper presents a set of basic problems concerning the control of an underactuated dynamic system. Exemplary system of a planar rigid body with a coupling input force is described. Lie brackets method is used to show accessibility of the system. A tracking problem is solved with computed torque algorithm. The coupling force makes the convergence to zero of all state variables errors impossible. After numerical simulation, stability of the system is mentioned
Gain scheduled controller design for thermo-optical plant
Authors: Veselý Vojtech , Osuský Jakub , Sekaj Ivan 
Published: November 2014

Abstract
This paper presents a gain scheduled controller design for MIMO and SISO systems in the frequency domain using the genetic algorithms approach. The proposed method is derived from the M-delta structure of closed loop MIMO (SISO) systems and the small gain theory is exploited to obtain the stability condition. An example of real system illustrates the effectiveness of the proposed output feedback gain scheduled controller design method and also the possibility to improve its performance using the genetic algorithm
Hybrid Technology of Hard Coal Mining from Seams Located at Great Depths
Authors: Czaja Piotr , Kamiński Paweł , Klich Jerzy , Tajduś Antoni 
Published: November 2014

Abstract
Learning to control fire changed the life of man considerably. Learning to convert the energy derived from combustion of coal or hydrocarbons into another type of energy, such as steam pressure or electricity, has put him on the path of scientific and technological revolution, stimulating dynamic development.
Since the dawn of time, fossil fuels have been serving as the mankind’s natural reservoir of energy in an increasingly great capacity. A completely incomprehensible refusal to use fossil fuels causes some local populations, who do not possess a comprehensive knowledge of the subject, to protest and even generate social conflicts as an expression of their dislike for the extraction of minerals. Our times are marked by the search for more efficient ways of utilizing fossil fuels by introducing non-conventional technologies of exploiting conventional energy sources. During apartheid, South Africa demonstrated that cheap coal can easily satisfy total demand for liquid and gaseous fuels.
In consideration of current high prices of hydrocarbon media (oil and gas), gasification or liquefaction of coal seems to be the innovative technology convergent with contemporary expectations of both energy producers as well as environmentalists. Known mainly from literature reports, underground coal gasification technologies can be brought down to two basic methods:

- shaftless method - drilling, in which the gasified seam is uncovered using boreholes drilled from the surface,
- shaft method, in which the existing infrastructure of underground mines is used to uncover the seams.

This paper presents a hybrid shaft-drilling approach to the acquisition of primary energy carriers (methane and syngas) from coal seams located at great depths. A major advantage of this method is the fact that the use of conventional coal mining technology requires the seams located at great depths to be placed on the off-balance sheet, while the hybrid method of underground gasification enables them to become a source of additional energy for the economy. It should be noted, however, that the shaft-drilling method cannot be considered as an alternative to conventional methods of coal extraction, but rather as a complementary and cheaper way of utilizing resources located almost beyond the technical capabilities of conventional extraction methods due to the associated natural hazards and high costs of combating them.
This article presents a completely different approach to the issue of underground coal gasification. Repurposing of the already fully depreciated mining infrastructure for the gasification process may result in a large value added of synthesis gas production and very positive economic effect.
The Three-Dimensional (3D) Numerical Stability Analysis of Hyttemalmen Open-Pit
Authors: Cała Marek , Kowalski Michał , Stopkowicz Agnieszka 
Published: November 2014

Abstract
The purpose of this paper was to perform the 3D numerical calculations allowing slope stability analysis of Hyttemalmen open pit (location Kirkenes, Finnmark Province, Norway). After a ramp rock slide, which took place in December 2010, as well as some other small-scale rock slope stability problems, it proved necessary to perform a serious stability analyses. The Hyttemalmen open pit was designed with a depth up to 100 m, a bench height of 24 m and a ramp width of 10 m. The rock formation in the iron mining district of Kirkenes is called the Bjornevaten Group. This is the most structurally complicated area connected with tectonic process such as folding, faults and metamorphosis. The Bjornevaten Group is a volcano-sedimentary sequence. Rock slope stability depends on the mechanical properties of the rock, hydro-geological conditions, slope topography, joint set systems and seismic activity. However, rock slope stability is mainly connected with joint sets. Joints, or general discontinuities, are regarded as weak planes within rock which have strength reducing consequences with regard to rock strength. Discontinuities within the rock mass lead to very low tensile strength. Several simulations were performed utilising the RocLab (2007) software to estimate the gneiss cohesion for slopes of different height. The RocLab code is dedicated to estimate rock mass strength using the Hoek-Brown failure criterion. Utilising both the GSI index and the Hoek-Brown strength criterion the equivalent Mohr-Coulomb parameters (cohesion and angle of internal friction) can be calculated. The results of 3D numerical calculations (with FLA3D code) show that it is necessary to redesign the slope-bench system in the Hyttemalmen open pit. Changing slope inclination for lower stages is recommended. The minimum factor of safety should be equal 1.3. At the final planned stage of excavation, the factor of safety drops to 1.06 with failure surface ranging through all of the slopes. In the case of a slope angle 70° for lower stages, FS = 1.26, which is not enough to provide slope stability. Another series of calculations were therefore performed taking water table lowering into consideration, which increases the global safety factor. It was finally evaluated, that for a water table level of 72 m the factor of safety equals 1.3, which is enough to assure global open-pit stability.
Influence of Mining Operating Conditions on Fault Behavior
Authors: Burtan Zbigniew , Zorychta Andrzej , Cieślik Jerzy , Chlebowski Dariusz 
Published: November 2014

Abstract
This article concerns numerical modeling of the impact of mining operations on fault behavior, carried out on the basis of a calculation program based on the finite element method. The calculations and their graphic results related to the reactions of vertical discontinuity on the mining operations that run along its boundary under changing operating parameters, such as geometry of the field and direction of mining with respect to the fault, as well as the method of liquidation of the caving zone. The behavior of the fault was analyzed based on distributions in the plane of shear stress and slip, together with their range and energy dissipated due to friction. The results of numerical calculations made it possible to draw conclusions on the impact of faults and the impact of operating conditions of mining in their vicinity on the level of seismic hazard.
Behaviour of Frictional Joints in Steel Arch Yielding Supports
Authors: Horyl Petr , Šňupárek Richard , Maršálek Pavel 
Published: November 2014

Abstract
The loading capacity and ability of steel arch supports to accept deformations from the surrounding rock mass is influenced significantly by the function of the connections and in particular, the tightening of the bolts. This contribution deals with computer modelling of the yielding bolt connections for different torques to determine the load-bearing capacity of the connections. Another parameter that affects the loading capacity significantly is the value of the friction coefficient of the contacts between the elements of the joints. The authors investigated both the behaviour and conditions of the individual parts for three values of tightening moment and the relation between the value of screw tightening and load-bearing capacity of the connections for different friction coefficients. ANSYS software and the finite element method were used for the computer modelling. The solution is nonlinear because of the bi-linear material properties of steel and the large deformations. The geometry of the computer model was created from designs of all four parts of the structure. The calculation also defines the weakest part of the joint’s structure based on stress analysis. The load was divided into two loading steps: the pre-tensioning of connecting bolts and the deformation loading corresponding to 50-mm slip of one support. The full Newton-Raphson method was chosen for the solution. The calculations were carried out on a computer at the Supercomputing Centre VSB-Technical University of Ostrava.
Physical activity based intervention program on health, bone mineral density and fitness status for rheumatology patient over 60 years of age
Authors: Kopkáné Plachy Judit , Vécseyné Kovách Magdolna , Ihász Ferenc , Bognár József 
Published: November 2014

Summary

Study aim: regular physical activity is important both for the prevention of illnesses and for rehabilitation purposes because it has significant impact on the physical and mental health of the elderly. The purpose of this study was to assess whether two different half-year regular training programmes had positive effects on health dimensions, bone mineral density, and fitness status in population of women aged over 60 years.

Material and methods: older women were assessed in a supervised exercise trial conducted at a rheumatology centre. A half-year intervention program involved 45 women (N = 45) aged over 60 years in Hungary. The sample was randomly divided into three groups. The “Training group” (n = 14; M age 64.07 years) did physical exercises three times per week. The “Mental group” (n = 16; M age 67.88 years) had two physical exercise sessions and one group discussion session about healthy lifestyle. The “Control group” (n = 15; M age 63.73 years) was not involved in any activities. Physical and mental health status (SF-36), bone mineral density (BMD), and fitness status (FFFT) were analysed.

Results: repeated measures ANOVA produced a significant main effect (F = 2389; p < 0.001). The differences between the “Training” and “Control” groups (p < 0.01) and between the “Mental” and “Control” groups (p < 0.05) were meaningful. The Group x Time comparison was significant in six scales of health status measurements; two scales of bone mineral density grew significantly. All the fitness test variables show significant results in between subjects effect.

Conclusions: both the Training and Mental groups significantly contributed to a better health status of the participants.
Analysis of the Distribution of Chemical Compounds from Fly Ash Exposed to Weather Conditions
Authors: Sambo Aleksandra , Szymanek Arkadiusz 
Published: November 2014

Abstract
The paper presents investigation results of the migration of a chemical compound contained in fly ash deposited on a dry furnace waste landfill site exposed to weather conditions. Climate conditions are able to significantly affect chemical component distribution in a block of deposited, moving chemical compounds to different depths. The main aim of the investigations was to determine the chemical component distribution of deposited fly ash in the landfill. Identification of chemical components based on XRF analysis indicated the existence of differences in both tested storage layer and the fraction of fly ash.
Adsorption in Perfect Mixing Tank – Comparison of Exact and Approximate Kinetic Models
Authors: Kupiec Krzysztof , Gwadera Monika , Larwa Barbara 
Published: November 2014

Abstract
Periodic adsorption in a perfect mixing tank of a limited volume was considered. It was assumed that the adsorption rate is limited by diffusion resistance in a pellet. The approximate model of diffusion kinetics based on a continued fraction approximation was compared with the exact analytical solution. For the approximate model an algorithm was developed to determine a temporal variation of the adsorbate concentration in the pellet. The comparison was made for different values of the adsorbent load factor. In the numerical tests different shapes of pellets were considered. Both the numerical tests as well as our own experimental results showed that the approximate model provides results that are in good agreement with the exact solution. In the experimental part of this work adsorption of p-nitrophenol and acetic acid from aqueous solutions on cylindrical pellets of activated carbon was conducted.
Cfd Analysis of Heat Transfer in a Microtubular Solid Oxide Fuel Cell Stack
Authors: Pianko-Oprych Paulina , Kasilova, Ekaterina , Jaworski Zdzisław 
Published: November 2014

Abstract
The aim of this work was to achieve a deeper understanding of the heat transfer in a microtubular Solid Oxide Fuel Cell (mSOFC) stack based on the results obtained by means of a Computational Fluid Dynamics tool. Stack performance predictions were based on simulations for a 16 anodesupported mSOFCs sub-stack, which was a component of the overall stack containing 64 fuel cells. The emphasis of the paper was put on steady-state modelling, which enabled identification of heat transfer between the fuel cells and air flow cooling the stack and estimation of the influence of stack heat losses. Analysis of processes for different heat losses and the impact of the mSOFC reaction heat flux profile on the temperature distribution in the mSOFC stack were carried out. Both radiative and convective heat transfer were taken into account in the analysis. Two different levels of the inlet air velocity and three different values of the heat losses were considered. Good agreement of the CFD model results with experimental data allowed to predict the operation trends, which will be a reliable tool for optimisation of the working setup and ensure sufficient cooling of the mSOFC stack.
Influence of Selected Parameters on Ash Particle Trajectories When Modelling Deposition on Superheater Tubes in Pulverised Coal Boilers Using Fluent Code
Authors: Wacławiak Krzysztof , Kalisz Sylwester 
Published: November 2014

Abstract
Widely used CFD codes enable modelling of PC boilers operation. One of the areas where these numerical simulations are especially promising is predicting deposition on heat transfer surfaces, mostly superheaters. The basic goal of all simulations is to determine trajectories of ash particles in the vicinity of superheater tubes. It results in finding where on the surface the tube will be hit by particles, and what diameter and mass flow of the particles are. This paper presents results of CFD simulations for a single tube and a bundle of in-line tubes as well. It has been shown that available parameters like ash particle density, shape factor, reflection coefficients affect the trajectories in a different way. All the simulations were carried out with Fluent code of Ansys software.