bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite element analysis of anterior cruciate ligament reconstruction techniques: A comparison of the mechanical properties of all-inside fixation and traditional fixation
Authors: Chen Xiaodong , Xue Changguo , Li Kuanxin , Mu Kecheng , Yao Cheng , Wang Zhiyan , Chen Hongzhi , Zhang Jun 
Published: August 2024

ObjectiveThe main purpose of this study was to explore the mechanical properties of the anterior cruciate ligament and its attachments following reconstruction with the all-inside technique after anterior cruciate ligament injury.MethodsKnee joint computed tomography data were collected from healthy volunteers, and knee joint models were created using Mimics software. A normal knee joint model, an all-inside reconstructed anterior cruciate ligament model, and a traditional reconstructed anterior cruciate ligament model were established. A tensile force of 134 N and a bending moment of 5 N/m were applied at the anterior aspect of the proximal tibia in these three models. The knee joint was subjected to external rotation, internal rotation, varus, valgus, flexion, and extension under this bending moment. The magnitude and distribution of stress on the ligament or graft and the magnitude and distribution of stress on the graft attachments were observed under different loading conditions.ResultsUnder different external forces, the maximum stress on the ligament in the normal model fluctuated from 1.949 to 18.302 MPa, with an uncertain distribution of maximum stress. The maximum stress on the graft in the all-inside reconstructed anterior cruciate ligament model fluctuated from 0.705 to 3.465 MPa and was mainly distributed at the junction of the graft and the tibial footprint. In the traditional reconstructed anterior cruciate ligament model, the maximum stress on the graft fluctuated from 5.012 to 59.269 MPa and was primarily distributed at the junction of the interference screw and the graft. The concentration of stress on the loop and plate in the all-inside reconstructed anterior cruciate ligament model fluctuated from 70.461 to 346.363 MPa, with maximum stress distributed at the junction of the loop and the tibial surface. The maximum stress on the interference screw in the traditional reconstructed anterior cruciate ligament model fluctuated from 10.184 to 92.298 MPa, with maximum stress primarily distributed at the end of the interference screw.ConclusionUnder different external forces, the graft used in all-inside anterior cruciate ligament reconstruction is subjected to fewer external forces than that used in traditional anterior cruciate ligament reconstruction, which may indicate a relatively stable mechanical environment. The strength of the loop and plate can theoretically tolerate daily knee joint movements of patients without injury.
Based on mutated aptamer-smartphone colorimetric detection of metronidazole in milk
Authors: Zhang Sicheng , Qin Yadi , Yuan Jie , Wang Yu , Yao Jun , Zhang Minwei 
Published: August 2024

Excessive residue of metronidazole (MNZ) in food is harmful to the human body. There is an urgent demand to develop a portable tool for MNZ detection on-site. In this study, fifteen aptamers were prepared through targeted base mutation. Apt1-3 with the highest enrichment was chosen for further study. Its affinity was characterized by molecular docking simulation, AuNPs colorimetric assay, graphene oxide (GO) fluorescence assay, and exonuclease assay. Kd was determined by GO fluorescence assay (Kd: 92.60 ± 25.59 nM). Its specificity was also characterized by an exonuclease assay. A novel aptasensor was constructed by using the newly identified aptamer combined with the smartphone dark box. The principle of color change is caused by the aggregation state of AuNPs. Smartphones act as reading instruments. The detection can be completed in just a few seconds without the aid of instruments, achieving a detection limit of 0.15 nmol/mL and a range of 6.7–44.4 nmol/mL (R2 = 0.9810). Therefore, the constructed smartphone colorimetric sensor based on mutant aptamers has important applications in food detection.
Liquid biopsy for diagnostic and prognostic evaluation of melanoma
Authors: Slusher Nicholas , Jones Nicholas , Nonaka Taichiro 
Published: August 2024

Melanoma is the most aggressive form of skin cancer, and the majority of cases are associated with chronic or intermittent sun exposure. The incidence of melanoma has grown exponentially over the last 50 years, especially in populations of fairer skin, at lower altitudes and in geriatric populations. The gold standard for diagnosis of melanoma is performing an excisional biopsy with full resection or an incisional tissue biopsy. However, due to their invasiveness, conventional biopsy techniques are not suitable for continuous disease monitoring. Utilization of liquid biopsy techniques represent substantial promise in early detection of melanoma. Through this procedure, tumor-specific components shed into circulation can be analyzed for not only diagnosis but also treatment selection and risk assessment. Additionally, liquid biopsy is significantly less invasive than tissue biopsy and offers a novel way to monitor the treatment response and disease relapse, predicting metastasis.
Prognostic implications of thyroid hormones in acute aortic dissection: mediating roles of renal function and coagulation
Authors: Shen Xuejun , Wu Shiwan , Yan Jingyi , Yan Hongle , Zhou Shuyi , Weng Huozhen , Yang Shengli , Li Weiping 
Published: August 2024

BackgroundThyroid hormones significantly influence cardiovascular pathophysiology, yet their prognostic role in acute aortic dissection (AAD) remains inadequately explored. This study assesses the prognostic value of thyroid hormone levels in AAD, focusing on the mediating roles of renal function and coagulation.MethodsWe included 964 AAD patients in this retrospective cohort study. Utilizing logistic regression, restricted cubic splines, and causal mediation analysis, we investigated the association between thyroid hormones and in-hospital mortality and major adverse cardiovascular events (MACEs).ResultsIn AAD patients overall, an increase of one standard deviation in FT4 levels was associated with a 31.9% increased risk of MACEs (OR 1.319; 95% CI 1.098–1.584) and a 36.1% increase in in-hospital mortality (OR 1.361; 95% CI 1.095–1.690). Conversely, a higher FT3/FT4 ratio was correlated with a 20.2% reduction in risk of MACEs (OR 0.798; 95% CI 0.637–0.999). This correlation was statistically significant predominantly in Type A AAD, while it did not hold statistical significance in Type B AAD. Key renal and coagulation biomarkers, including blood urea nitrogen, creatinine, cystatin C, prothrombin time ratio, prothrombin time, and prothrombin time international normalized ratio, were identified as significant mediators in the interplay between thyroid hormones and MACEs. The FT3/FT4 ratio exerted its prognostic influence primarily through the mediation of renal functions and coagulation, while FT4 levels predominantly impacted outcomes via a partial mediation effect on coagulation.ConclusionFT4 levels and the FT3/FT4 ratio are crucial prognostic biomarkers in AAD patients. Renal function and coagulation mediate the association between the thyroid hormones and MACEs.
Power plant units for CO2 neutral energy security in Switzerland
Authors: Züttel Andreas , Nützenadel Christoph , Schlapbach Louis , Gilgen Paul W. 
Published: August 2024

Graphical AbstractFuture supply of Switzerland with renewable energy. Assuming the volume of the hydroelectric storage lakes is doubled, the roof area is covered with photovoltaics, and eight power plant units are able to produce 1 GW on demand and are fueled with hydrogen or bio-oil. The reserves are the existing oil tanks, and the bio-oil is also used for aviation. Bio-oil can be produced in abundant places, e.g., Australia or Africa, where palm oil plantations are installed.
Fluid-structure interaction of flexible collectors affects particle capture efficiency at ecologically relevant collector Reynolds numbers
Authors: Sewak Kyle , Hassan Marwan , Ackerman Josef D. 
Published: August 2024

Introduction: The capture of suspended particles, which is an important process in many aquatic and terrestrial ecosystems, has been modeled using stationary rigid collectors and, more recently those that move in response to flow-induced vibrations. These models do not, however, account for collector flexibility, despite the fact that many biological collectors, especially aquatic collectors, exhibit flexibility.Methods: This study examined the effect of collector flexibility (indicated by the Young’s Modulus, E; range = 10–3–102 GPa) on particle capture efficiency (η; flux of captured particles: flux of particles) at different collector Reynolds numbers (Rec where the collector diameter [dc] is the length scale; range = 30–508) in a recirculating flow chamber.Results: Patterns in η were generally similar for flexible and rigid collectors until moderate Rec (∼374) when higher η were observed on the most flexible collectors. This threshold corresponded to periods of vortex induced motions in which the oscillation frequency of the collector transverse to the flow direction was &gt;4 Hz and the maximum amplitude of the oscillation relative to dc was &gt;60% in the transverse and &gt;100% in the longitudinal direction.Discussion: Given the range in E examined in this study, it is likely that particle capture on flexible natural collectors has been underestimated using the standard model of a rigid stationary or oscillating collector. The role of collector flexibility should be considered in models and studies of particle capture in natural systems.
The association between serum 25-hydroxyvitamin D levels and retinopathy of prematurity in preterm infants
Authors: Yin Xiangyun , Xu Shimin , Zhang Xuefei , Li Liangliang , Xi Hongmin , Ma Lili , Sun Mengya , Yang Ping , Li Xianghong , Jiang Hong 
Published: August 2024

ObjectiveThis study aimed to investigate the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and retinopathy of prematurity (ROP) in premature infants one month after birth.MethodsPreterm infants (gestational age &lt;32 weeks) admitted to the Affiliated Hospital of Qingdao University from 2017 to 2022 were divided into ROP and non-ROP groups based on ROP occurrence any stage. Serum 25(OH)D levels and clinical data were compared between the two groups at 1 month after birth, and the relationship between vitamin D levels and ROP was analyzed.ResultsAmong the 217 premature infants included, 55 (25.35%) were in the ROP group, and 162 (74.65%) were in the non-ROP group. The ROP group had lower gestational age and birth weight, longer invasive ventilation (IV), non-invasive ventilation (NIV), and oxygen therapy times compared to the non-ROP group. Apgar scores, cesarean delivery, and antenatal steroids ratios were lower in the ROP group, while sepsis and pulmonary surfactant utilization ratios were higher (all p &lt; 0.05). Significant differences in serum 25-(OH)D levels were observed among children in the non-ROP group (14.20 ± 5.07 ng/ml), ROP treated group (7.891 ± 1.878 ng/ml), and untreated group (12.168 ± 4.354 ng/ml) (p &lt; 0.001). Multivariate regression analysis identified antenatal steroids as protective factors and lower birth weight, serum 25-(OH)D levels, long-term invasive mechanical ventilation, and sepsis as independent risk factors for ROP in premature infants.ConclusionVitamin D, lower birth weight, long-term invasive mechanical ventilation, and sepsis were associated with incidence of ROP in preterm infants. Vitamin D was associated with the severity of ROP, emphasizing the importance of prudent vitamin D supplementation and regular monitoring of serum 25-(OH)D levels.
Global research development of chondrosarcoma from 2003 to 2022: a bibliometric analysis
Authors: Duan Hansong , Li Jiatong , Ma Jianfei , Chen Ting , Zhang He , Shang Guanning 
Published: August 2024

BackgroundChondrosarcomas are common primary malignant bone tumors; however, comprehensive bibliometric analysis in this field has not yet been conducted. Therefore, this study aimed to explore the research hotspots and trends in the field of chondrosarcoma through bibliometric analysis to help researchers understand the current status and direction of research in the field.MethodsArticles and reviews related to chondrosarcoma published between 2003 and 2022 were retrieved from the Web of Science. Countries, institutions, authors, journals, references, and keywords in this field were visualized and analyzed using CtieSpace and VOSviewer software.ResultsBetween 2003 and 2022, 4,149 relevant articles were found. The number of articles published on chondrosarcoma has increased significantly annually, mainly from 569 institutions in China and the United States, and 81 in other countries. In total, 904 authors participated in the publication of studies related to chondrosarcomas. Over the past 20 years, articles on chondrosarcoma have been published in 958 academic journals, with Skeletal Radiology having the highest number of publications. Furthermore, keywords such as “gene expression,” “radiotherapy,” “experience,” and “apoptosis” have been popular in recent years.ConclusionOver the past 20 years, the global trend in chondrosarcoma research has primarily been clinical research, with basic research as a supplement. In the future, communication and exchange between countries and institutions should be strengthened. Further, the future main research hotspots in the field of chondrosarcoma include mutated genes and signaling pathways, precision surgical treatment, proton therapy, radiation therapy, chemotherapy, immunotherapy, and other aspects.
The Potential of Bacillus Species as Probiotics in the Food Industry: A Review
Authors: Payne Jessie , Bellmer Danielle , Jadeja Ravi , Muriana Peter 
Published: August 2024

The demand for probiotics is increasing, providing opportunities for food and beverage products to incorporate and market these foods as a source of additional benefits. The most commonly used probiotics belong to the genera of Lactobacillus and Bifidobacterium, and traditionally these bacteria have been incorporated into dairy products, where they have a wider history and can readily survive. More recently, there has been a desire to incorporate probiotics into various food products, including baked goods. In recent years, interest in the use of Bacillus species as probiotics has greatly increased. The spores of various Bacillus species such as Bacillus coagulans and Bacillus subtilis, have significantly improved viability and stability under harsher conditions during heat processing. These characteristics make them very valuable as probiotics. In this review, factors that could affect the stability of Bacillus probiotics in food products are highlighted. Additionally, this review features the existing research and food products that use Bacillus probiotics, as well as future research opportunities.
Pathogenicity factors and antibiotic resistance strains of <i>Enterococcus faecalis</i> isolated from prostate secretions in males with chronic bacterial prostatitis
Authors: Kartashova O. L. , Pashinina O. A. , Pashkova T. M. , Gritsenko V. A. , Popova L. P. 
Published: August 2024

Aim. To characterize pathogenic phenophiles and genoprophiles, as well as antibiotic c resistance of Enterococcus faecalis strains isolated from prostate secretions in males with chronic bacterial prostatitis (CBP).Materials and methods. Enterococci were isolated using standard bacteriological methods on the Schaedler broth and identified by mass spectrometry. The genetic determinants encoding pathogenicity and antibiotic resistance factors were determined by PCR. The ability of enterococci to inactivate lysozyme (ALA), form biofilms, exhibit hemolysis and adhesion was determined by the photometric method; the penetrance and expressiveness of sIgA protease and anti-cytokine activities were evaluated by enzyme immunoassay.Results. The isolated strains E. faecalis had a pronounced pathogenic potential, being characterized by the presence of virulence factors (hemolytic activity, adhesive ability) and persistence (ALA, BPO), the ability to inactivate proinflammatory cytokines and sIgA, variable antibiotic resistance with resistance to amikacin and kanamycin. The determinants responsible for the synthesis of proteolytic enzymes (gelE, sprE) and cytolysin (a complex of cyl operon genes), as well as those responsible for evading macroorganism immunity effectors (esp) and the synthesis of adhesion proteins (asa), were identified in the genotype of E. faecalis cultures. The presence of genetic determinants of antibiotic resistance aph(3’)-IIIa, tetM, vanA was found in all isolates.Conclusion. The obtained results on pathogenic bioprophiles of clinical enterococcal strains can be used to improve approaches to CBP diagnosis. The data on antibiotic resistance (at the level of phenotype and genotype) should be taken into account in the empirical and personalized choice of drugs for a combined treatment of CBP patients.
Identifikasi Potensi Objek Wisata Pantai Batu Meja di Kelurahan Tongkaina
Authors: Rattu Frans V , Tulung Easter Ch.M. , Sangian Meiske M 
Published: August 2024

Penelitian ini bertujuan untuk mengidentifikasi apa saja yang dimiliki Obyek Wisata Pantai Batu Meja kemudian nanti dapat diarahkan pengembangan Obyek yang cocok, serta menginventaris permasalahan-permasalahan yang di hadapi dalam Obyek Wisata Pantai Batu Meja ini. Penelitian ini menggunakan Metode observasi deskripsi. Hasil penelitian menunjukkan bahwa wisata pantai Batu Meja di Kelurahan Tongkaina memiliki daya tarik berupa pantai yang indah dengan karang-karang yang besar yang berbentuk datar sehingga disebut batu meja; 2) hamparan hutan mangrove dangan berbagai species; 3) pemandangan bawah laut yang indah sehingga dapat dijadikan tempat wisata menyelam; dan 4) pemandangan pantai yang mengesankan apalagi disaat sunset. Kesimpulan yang diambil objek wisata pantai Batu Meja memilihi potensi yang sangai baik untuk dikembangkan menjadi objek wisata andalan di kelurahan Tongkaina. Wilayah pesisir pantai dan laut yang memiliki keaslian lingkungan alam dan belum tersentuh secara teknologi dapat menjadi salah satu aset kelurahan untuk meningkatkan perekonomian masyarakat.
Stratified polymer dissolution model based on impedance data from quartz crystal microbalance method
Authors: Jin Yuqing , Ito Yuko Tsutsui , Kozawa Takahiro , Hasebe Takashi , Sakamoto Kazuo , Muramatsu Makoto 
Published: August 2024

Abstract
In lithography, the development process is essential for achieving high fidelity. The quartz crystal microbalance (QCM) method is a primary tool for analyzing the dissolution kinetics of resist polymers by measuring their frequency and impedance. However, impedance charts are underutilized. We propose a stratified polymer dissolution model (SPDM) to simulate polymer dissolution in developers and analyze QCM charts. Using SPDM, we accurately reproduced both the frequency and impedance charts. The feature values describing the dissolution kinetics were successfully extracted from the QCM charts, enabling the investigation of the effects of developers on dissolution kinetics.
Origin of Chromitite-Anorthosite Interlayering in the Bushveld Complex
Authors: Maier Wolfgang D. , Barnes Sarah-Jane 
Published: August 2024

ABSTRACT
An idealized stratigraphic section of the five main chromitite-bearing cyclic units of the Upper Critical Zone of the Bushveld Complex typically consists of basal chromitite overlain by pyroxenite, norite, and anorthosite. Such units can be explained by classical fractional crystallization from a Mg-rich basalt followed by injection of new magma. However, in some cases both the underlying and overlying rocks of the chromitite are anorthosite. Furthermore, most of the interstitial material in the chromitites is not pyroxene, which would be the mineral expected to crystallize with chromite, but rather it is oikocrystic plagioclase. Finally, recent age dating suggests that the cyclic units may not have been emplaced in stratigraphic order, with the upper group chromitites being older than the underlying middle group chromitites. In order to reconcile some of these data we compiled field and drill core observations from the Upper Critical Zone. Of particular interest is the MG2–MG3 interval, showing pronounced layering, abundant autoliths of various shapes and compositions, as well as flame structures and boudinage. Many of these features are typical of sedimentary mass flows, suggesting that the MG2–MG3 interval formed via granular flow of intruding chromite-orthopyroxene crystal slurries that deposited chromitite and orthopyroxenite. The heat of the new magma influx caused partial melting of the host leuconorite to produce restitic anorthosite and buoyant noritic melt. The latter infiltrated the slurry, resulting in a disequilibrium assemblage of cumulus chromite and oikocrysts of plagioclase.
Tecnologías Emergentes Usadas en el Envasado y Procesamiento de Productos Cárnicos Convencionales y No Convencionales
Authors: Idrogo Torres Yesly Karina , Delgado Tapia Doris Elena 
Published: August 2024

La preocupación por la contaminación de alimentos y la importancia de proteger al público de los riesgos asociados han impulsado la adopción de métodos emergentes en el procesamiento y conservación de carnes. Estas tecnologías juegan un rol crucial en la prolongación de la vida útil e influyen en la calidad de los productos cárnicos. El objetivo de este estudio fue analizar las tecnologías emergentes aplicadas en el envasado y procesamiento de la industria cárnica. La metodología consistió en una revisión bibliográfica bajo el enfoque cualitativo, utilizando el análisis crítico-síntesis de diversas fuentes como resúmenes, trabajos de investigación completos y libros recopilados de bases de datos especializadas como Science Direct, Elsevier, Springer, Scopus, PubMed y MDPI. La metodología de análisis incluyó etapas de lectura y evaluación crítica, extracción de información, síntesis y organización de datos, así como la formulación de opiniones y conclusiones basadas en la información recopilada. Entre los resultados destaca que las diferentes tecnologías emergentes aplicadas en productos cárnicos tanto convencionales como no convencionales, están ligadas al envasado inteligente que se encuentran en desarrollo, concluyendo que ofrecen soluciones innovadoras para prolongar la vida útil, seguridad y calidad del producto cárnico, pero necesitan ser evaluadas para su implementación.