bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational and Experimental Characterization of a Cagelike Fe15 Polycation
Authors: Hou Yu , Fang Xikui , Kwon Kideok D. , Criscenti Louise J. , Davis Danae , Lambert Tim , Nyman May 
Published: January 2013

AbstractPolynuclear open‐shell transition‐metal clusters are synthetically challenging, yet fascinating from the perspective of their diverse properties. Iron clusters in particular can exhibit interesting magnetic and electrochemical behaviour, and they can potentially be exploited as models for geochemical processes at iron oxide surfaces. From solvothermal synthesis, we have obtained a cagelike polycationic FeIII cluster, [Fe15Cl6O6(OH)2(C3H6O2)12]+, which features the common polyoxometalate (POM) Keggin ion trimer fragments oriented in an inverse fashion relative to the centre of the cluster. In addition to solid‐state structural characterization, we have examined the magnetic properties, which revealed the presence of antiferromagnetic exchange within the polynuclear system. Electrospray‐ionization mass spectrometry (ESI‐MS) revealed that the Fe9 core of the cluster remains intact upon dissolution, whereas the Fe–Cl2+ caps are more labile. Computational studies agree well with the observed antiferromagnetic character, as well as the HOMO–LUMO bandgap, and also describe these frontier orbitals.
Quantifying different riverbank erosion processes during an extreme flood event
Authors: R. Grove James , Croke Jacky , Thompson Christopher 
Published: January 2013

ABSTRACTRiverbank erosion is a major contributor to catchment sediment budgets. At large spatial scales data is often restricted to planform channel change, with little information on process distributions and their sediment contribution. This study demonstrates how multi‐temporal LiDAR and high resolution aerial imagery can be used to determine processes and volumes of riverbank erosion at a catchment scale. Remotely sensed data captured before and after an extreme flood event, enabled a digital elevation model of difference (DoD) to be constructed for the channel and floodplain. This meant that: the spatial area that could be assessed was extensive; three‐dimensional forms of bank failures could be mapped at a resolution that enabled process inference; and the volume and rates of different bank erosion processes over time could be assessed. A classification of riverbank mass failures, integrating form and process, identified a total of 437 mass failure polygons throughout the study area. These were interpreted as wet flow mass failures based on the presence of a well defined scarp wall and the absence of failed blocks on the failure floor. The failures appeared to be the result of: bank exfiltration, antecedent moisture conditions preceding the event, and the historic development of the channel. Using one‐dimensional hydraulic modelling to delineate geomorphic features within the main boundary of the macrochannel, an estimated 1 466 322 m2of erosion was interpreted as fluvial entrainment, occurring across catchment areas from 30 to 1668 km2. Only 8% of the whole riverbank planform area was occupied by mass failures, whilst fluvial entrainment covered 33%. A third of the volume of material eroded came from mass failures, even though they occupied 19% of the eroded bank area. The availability of repeat LiDAR surveys, combined with high‐resolution aerial photography, was very effective in erosion process determination and quantification at a large spatial scale. Copyright © 2013 John Wiley & Sons, Ltd.
Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis
Authors: de Buy Wenniger Lucas J. Maillette , Doorenspleet Marieke E. , Klarenbeek Paul L. , Verheij Joanne , Baas Frank , Elferink Ronald P. Oude , Tak Paul P. , de Vries Niek , Beuers Ulrich 
Published: January 2013

Abstract

Immunoglobulin G4 (IgG4)-associated cholangitis (IAC) is a manifestation of the recently discovered idiopathic IgG4-related disease. The majority of patients have elevated serum IgG4 levels and/or IgG4-positive B-cell and plasma cell infiltrates in the affected tissue. We hypothesized that clonally expanded, class-switched IgG4-positive B cells and plasma cells could be causal to these poorly understood phenomena. In a prospective cohort of six consecutive IAC patients, six healthy controls, and six disease controls, we used a novel next-generation sequencing approach to screen the B-cell receptor (BCR) repertoires, in blood as well as in affected tissue, for IgG4+ clones. A full repertoire analysis of the BCR heavy chain was performed using GS-FLX/454 and customized bioinformatics algorithms (>10,000 sequences/sample; clones with a frequency ≥0.5% were considered dominant). We found that the most dominant clones within the IgG+ BCRheavy repertoire of the peripheral blood at baseline were IgG4+ only in IAC patients. In all IAC patients, but none of the controls, IgG4+ BCR clones were among the 10 most dominant BCR clones of any immunoglobulin isotype (IgA, IgD, IgM, and IgG) in blood. The BCR repertoires of the duodenal papilla comprised the same dominant IgG4+ clones as the paired peripheral blood samples. In all IAC patients, after 4 and 8 weeks of corticosteroid therapy the contribution of these IgG4+ clones to the IgG+ repertoire as well as to total BCR repertoire was marginalized, mirroring sharp declines in serum IgG4 titers and regression of clinical symptoms.

Conclusion:

The novel finding of highly abundant IgG4+ BCR clones in blood and tissue of patients with active IAC, which disappear upon corticosteroid treatment, suggests that specific B cell responses are pivotal to the pathogenesis of IAC.
Risk factors associated with complications in patients with chemotherapy‐induced febrile neutropenia in emergency department
Authors: Lynn Jiun‐Jen , Chen Kuan‐Fu , Weng Yi‐Ming , Chiu Te‐Fa 
Published: January 2013

AbstractFebrile neutropenia caused by chemotherapy is a frequent medical emergency associated with severe complications in the emergency department (ED). Timely administration of antibiotics is believed to improve patient outcomes for several infectious diseases such as pneumonia and sepsis but has not been thoroughly evaluated for reducing risk of complications in chemotherapy‐induced febrile neutropenia. The aim of this study was to evaluate associations between the risk factors and serious complications in patients presenting to the ED with febrile neutropenia. We reviewed the health information system database to identify a retrospective cohort of patients with febrile neutropenia who visited the ED of a tertiary medical hospital from January to December 2008. Only episodes of febrile neutropenia caused by chemotherapy for underlying cancer were included. Serious complications during hospitalization were defined as unstable hemodynamic status, respiratory distress, altered mental status, newly developed arrhythmia that required intervention, and death during hospitalization. Univariate and multivariate logistic regression analysis was performed to determine potential factors associated with serious complications. We further use decision tree approach to help analyze variables. Among a total of 81 febrile neutropenic episodes in 78 patients, 25 (30.8%) episodes of serious complications were identified. Latency of the first dose of antibiotics, pneumonia and platelet counts ≤ 50,000/mm3 were identified as independent factors associated with serious complications of febrile neutropenia. Earlier administration of antibiotics is associated with fewer complications in patients presenting to the ED with febrile neutropenia. Copyright © 2013 John Wiley & Sons, Ltd.
Particulate Matter Promotes In Vitro Receptor‐Recognizable Low‐Density Lipoprotein Oxidation and Dysfunction of Lipid Receptors
Authors: Manzano‐León Natalia , Mas‐Oliva Jaime , Sevilla‐Tapia Laura , Morales‐Bárcenas Rocío , Serrano Jesús , O´Neill Marie S. , García‐Cuellar Claudia M. , Quintana Raúl , Vázquez‐López Inés , Osornio‐Vargas Álvaro R. 
Published: January 2013

ABSTRACTParticulate matter may promote cardiovascular disease, possibly as a consequence of its oxidative potential. Studies using susceptible animals indicate that particulate matter aggravates atherosclerosis by increasing lipid/macrophage content in plaques. Macrophage lipid uptake requires oxidized low‐density lipoprotein and scavenger receptors; same receptors are involved in particulate matter uptake. We studied in vitro particulate matter potential to oxidize low‐density lipoproteins and subsequent cell uptake through scavenger receptors. Particulate matter‐induced low‐density lipoproteins oxidation was evaluated by the thiobarbituric acid assay. Binding/internalization was tested in wild type and scavenger receptor–transfected Chinese hamster ovary cells, and in RAW264.7 cells using fluorescently labeled low‐density lipoproteins. Dose‐dependent binding/internalization only occurred in scavenger receptor–transfected Chinese hamster ovary cells and RAW264.7 cells. Competition binding/internalization using particles showed that particulate matter induced decreased binding (∼50%) and internalization (∼70%) of particle‐oxidized low‐density lipoproteins and native low‐density lipoproteins. Results indicate that particulate matter was capable of oxidizing low‐density lipoproteins, favoring macrophage internalization, and also altered scavenger and low‐density lipoproteins receptor function. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:69‐76, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21452
Bovine herpesvirus type 4 infection modulates autophagy in a permissive cell line
Authors: Montagnaro Serena , Ciarcia Roberto , Pagnini Francesco , De Martino Luisa , Puzio Maria Valeria , Granato Giovanna Elvira , Avino Franca , Pagnini Ugo , Iovane Giuseppe , Giordano Antonio 
Published: January 2013

AbstractBovine herpesvirus type 4 (BoHV‐4), like other herpesviruses, induces a series of alterations in the host cell that modify the intracellular environment in favor of viral replication, survival and spread. This research examined the impact of BoHV‐4 infection on autophagy in BoHV‐4 infected Madin Darby bovine kidney (MDBK) cells. Protein extracts of BoHV‐4 infected and control MDBK cells were subjected to Western blot. The concentrations of the autophagy and apoptosis‐related proteins Beclin 1, p21, PI3 kinase, Akt1/2, mTOR, phospho mTOR, p62 and the light chain three (LC3) were normalized to the actin level and expressed as the densitometric ratio. Western blot analysis of virus‐infected cells revealed that autophagic degradation pathway was induced in the late phase of BoHV‐4 infection. After 48 h post‐infection the protein LC3II, which is essential for autophagy was found to be markedly increased, while infection of MDBK cells with BoHV‐4 resulted in a depletion of p62 levels. Becline 1, PI3 kinase, Akt1/2 and p21 expression increased between 24 and 48 h post‐infection. Surprisingly, mTOR and its phosphorylated form, which are negative regulators of autophagy, also increased after 24 h post‐infection. In conclusion, our findings suggest that BoHV‐4 has developed mechanisms for modulation of autophagy that are probably part of a strategy designed to enhance viral replication and to evade the immune system. Additional studies on the relationship between autophagy and BoHV‐4 replication and survival, in both lytic and latent replication phases, are needed to understand the role of autophagy in BoHV‐4 pathogenesis. J. Cell. Biochem. 114: 1529–1535, 2013. © 2013 Wiley Periodicals, Inc.
Bis‐μ‐oxo and μ‐η2:η2‐peroxo dicopper complexes studied within (time‐dependent) density‐functional and many‐body perturbation theory
Authors: Rohrmüller M. , Herres‐Pawlis S. , Witte M. , Schmidt W. G. 
Published: January 2013

AbstractBased on the equilibrium geometries of [Cu2(dbdmed)2O2]2+ and [Cu2(en)2O2]2+ obtained within density‐functional theory, we investigate their molecular electronic structure and optical response. Thereby results from occupation‐constrained as well as time‐dependent DFT (ΔSCF and TDDFT) are compared with Green's function‐based approaches within many‐body perturbation theory such as the GW approximation (GWA) to the quasiparticle energies and the Bethe‐Salpeter equation (BSE) approach to the optical absorption. Concerning the ground‐state energies and geometries, no clear trend with respect to the amount of exact exchange in the DFT calculations is found, and a strong dependence on the basis sets is to be noted. They affect the energy difference between bis‐μ‐oxo and μ‐η2:η2‐peroxo complexes by as much as 0.8 eV (18 kcal/mol). Even stronger, up to 5 eV is the influence of the exchange‐correlation functional on the gap values obtained from the Kohn‐Sham eigenvalues. Not only the value itself but also the trends observed upon the bis‐μ‐oxo to μ‐η2:η2‐peroxo transition are affected. In contrast, excitation energies obtained from ΔSCF and TDDFT are comparatively robust with respect to the details of the calculations. Noteworthy, in particular, is the near quantitative agreement between TDDFT and GWA+BSE for the optical spectra of [Cu2(en)2O2]2+. © 2013 Wiley Periodicals, Inc.
Management of localized gastric cancer
Authors: Blum Mariela A. , Takashi Taketa , Suzuki Akihiro , Ajani Jaffer A. 
Published: January 2013

AbstractGastric cancer continues to be a fatal disease with majority of cases presenting in late stages. For patients with advanced disease, we can only recommend palliative therapy. For localized gastric cancer, the approaches vary in various regions of the world. In western countries, preoperative chemotherapy or adjuvant chemo‐radiation is preferred; however in Asia, surgery followed by adjuvant chemotherapy is favored. The extent of the lymph node dissection also varies by region. D2 gastrectomy is difficult to implement in most western countries while it is standardized and is a routine in Asia. We recommend multidisciplinary evaluation of each patient before starting any therapy. The prognosis after resection depends of the pathologic stage. Long‐term survivors are often <50% in the West and <70% in many Asian countries. Regional and systemic recurrences are common. Improved systemic treatments are needed. Detailed studies of molecular biology might uncover novel therapeutic targets and prognostic subgroups. J. Surg. Oncol. 2013;107:265–270. © 2013 Wiley Periodicals, Inc.
Transoral robotic total laryngectomy
Authors: Smith Richard V. , Schiff Bradley A. , Sarta Catherine , Hans Stéphane , Brasnu Daniel 
Published: January 2013

AbstractObjectives/Hypothesis:Minimally invasive surgery has become the standard of care in many organ systems. Head and neck surgery has incorporated transoral surgery, either laser microsurgery or robotic resection, in the management of pharyngeal and laryngeal cancers. To date, the laryngeal procedures have taken the form of partial laryngectomy, as transoral approaches have not allowed reconstruction following total laryngectomy. We present the first series of transoral total laryngectomies.Study Design:Multinational, multi‐institutional prospective consecutive case series.Methods:Case series of completed and attempted transoral robotic surgery (TORS) total laryngectomy performed under an institutional review board protocol. The procedure was developed in the cadaver laboratory and applied to selected individuals requiring total laryngectomy for recurrent laryngeal cancer or post‐therapeutic organ dysfunction.Results:TORS total laryngectomy was successfully performed in five patients and was unsuccessful in two others. Two of the patients had postoperative fistulae, and all seven are without evidence of recurrent cancer and are swallowing orally without gastrostomy supplementation.Conclusions:TORS total laryngectomy is feasible and can be taught to other surgeons. Potential benefits of this approach are present for patients undergoing salvage laryngectomy and include improved wound healing and functional results. This procedure further extends the applications of robotic head and neck surgery. Laryngoscope, 2013
Survival outcomes in acute invasive fungal sinusitis: A systematic review and quantitative synthesis of published evidence
Authors: Turner Justin H. , Soudry Ethan , Nayak Jayakar V. , Hwang Peter H. 
Published: January 2013

Objectives/HypothesisAcute invasive fungal sinusitis (AIFS) is an aggressive and often fatal infection. Despite improvements in medical and surgical therapy, survival remains limited and the factors that contribute to patient outcomes remain poorly understood. The current study systematically reviews and quantitatively synthesizes the published literature to characterize prognostic factors associated with survival.Study DesignSystematic review.MethodsFifty‐two studies comprising a total of 807 patients met inclusion criteria and were used for analysis of treatment, presentation, and outcomes. Univariate and multivariate logistic regression was used to identify prognostic factors.ResultsAll studies were classified as level 4 evidence, as per definitions provided by the Oxford Center for Evidence‐Based Medicine. The most common presenting symptoms of patients with AIFS were facial swelling (64.5%), fever (62.9%), and nasal congestion (52.2%). Most patients were treated with a combination of intravenous antifungal medication and surgery. The overall survival rate was 49.7%. On univariate analysis, poor prognosis was associated with renal/liver failure, altered mental status, and intracranial extension. Patients who were diabetic, had surgery, or received liposomal amphotericin B had an improved chance of survival. On multivariate analysis, advanced age and intracranial involvement were identified as independent negative prognostic factors. Positive prognostic factors again included diabetes and surgical resection.ConclusionsThe overall mortality of patients with AIFS remains high, with only half of the patients surviving. Diabetic patients appear to have a better overall survival than patients with other comorbidities. Patients who have intracranial involvement, or who do not receive surgery as part of their therapy, have a poor prognosis.Level of EvidenceN/A.
Shortest paths avoiding forbidden subpaths
Authors: Ahmed Mustaq , Lubiw Anna 
Published: January 2013

AbstractWe study a variant of the shortest path problem in graphs: given a weighted graph Gand vertices sand t, and given a set Xof forbidden paths in G, find a shortest s‐ tpath Psuch that no path in Xis a subpath of P. Path Pis allowed to repeat vertices and edges. We call each path in Xan exception, and our desired path a shortest exception avoiding path. We formulate a new version of the problem where the algorithm has no a priori knowledge of X, and finds out about an exception x∈Xonly when a path containing xfails. This situation arises in computing shortest paths in optical networks. We give an algorithm that finds a shortest exception avoiding path in time polynomial in |G| and |X|. The main idea is to use a shortest path algorithm incrementally after replicating vertices when an exception is discovered. © 2013 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2013
Distance edge coloring and collision‐free communication in wireless sensor networks
Authors: Drira Kaouther , Seba Hamida , Effantin Brice , Kheddouci Hamamache 
Published: January 2013

AbstractMotivated by the problem of link scheduling in wireless sensor networks where different sensors have different transmission and interference ranges and may be mobile, we study the problem of “distance edge coloring” of graphs, which is a generalization of proper edge coloring. Let Gbe a graph modeling a sensor network. An ℓ‐distance edge coloring of Gis a coloring of the edges of Gsuch that any two edges within distance ℓof each other are assigned different colors. The parameter ℓis chosen, so that the links corresponding to two edges that are assigned the same color do not interfere. We investigate the ℓ‐distance edge coloring problem on several families of graphs that can be used as topologies in sensor deployment. We focus on determining the minimum number of colors needed and optimal coloring algorithms. © 2013 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2013
Parental information, motivation, and adherence behaviors among children with sickle cell disease
Authors: Raphael Jean L. , Butler Ashley M. , Rattler Tiffany L. , Kowalkowski Marc A. , Mueller Brigitta U. , Giordano Thomas P. 
Published: January 2013

AbstractBackgroundIdentification of psychosocial correlates of health care utilization has become an important strategy in improving clinical care. The objective of the study was to examine the fit of the Information‐Motivation‐Behavioral Skills (IMB) model, applied to health care utilization among children with sickle cell disease (SCD).ProcedureParticipants were parents of 150 children, ages 1–17 years, receiving care in a sickle cell center. Parents completed questionnaires assessing information, motivation, adherence behaviors, and other factors with respect to SCD management. Data regarding health care utilization in the previous 12 months were obtained from parent report and electronic medical records. Stepwise multiple regression analysis was conducted to determine associations between IMB factors and health care use.ResultsParents rated highly in the domains of information, motivation, and adherence behaviors for managing their child's SCD. Children of parents reporting higher satisfaction with social supports had higher odds (OR 1.49, 95% CI 1.03–2.15) of two or more routine hematology visits in the previous 12 months. Neither information nor adherence behavior was associated with urgent or routine care use. Among other variables measured, high parental illness‐related stress and child health status reported as fair/poor were the strongest predictors of urgent care use while private insurance type was the strongest predictor of routine care use.ConclusionsAmong IMB factors, social support was associated with routine health care utilization. Social support and parental illness‐related stress may serve as important, modifiable targets in interventions to allocate needed resources to families and reduce unnecessary medical care. Pediatr Blood Cancer 2013; 60: 1204–1210. © 2013 Wiley Periodicals, Inc.
Thermal conductive performance of organosoluble polyimide/BN and polyimide/(BN + ALN) composite films fabricated by a solution‐cast method
Authors: Kuo D.H. , Lin C.Y. , Jhou Y.C. , Cheng J.Y. , Liou G.S. 
Published: January 2013

AbstractOrganosoluble polyimide (PI)/ceramic composite films with different BN or (BN + AlN) contents were under investigation for their thermal conductive performances. The chosen polyimide constituted by 4,4′‐oxydiphthalic dianhydride/2,2‐bis(3‐amino‐4‐hydroxyphenyl)hexafluor opropane could be dissolved and cast into thin films at room temperature. The commercially available BN and AlN fillers up to a volume ratio of 0.6 were added to the polyimide and their thermal conductive performances were measured. BN powders needed a surface precoating treatment to avoid sedimentation. The dense and flexible PI/BN composite films, after a drying treatment at 200°C, showed high thermal conductivity of 2.3 W/m·K−1 at a BN volume ratio of 0.6, as compared with 0.13 W/m·K−1 for pristine polyimide. However, in the case of PI/(BN + AlN) composite films, thermal conductive performance degraded because the films became highly porous at the higher AlN content. POLYM. COMPOS., 2013. © 2013 Society of Plastics Engineers