bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human adult bone marrow-derived stem cells decrease severity of lipopolysaccharide-induced acute respiratory distress syndrome in sheep
Authors: Rojas Mauricio , Cárdenes Nayra , Kocyildirim Ergin , Tedrow John R , Cáceres Eder , Deans Robert , Ting Anthony , Bermúdez Christian 
Published: March 2014

Abstract
Introduction
Acute respiratory distress syndrome (ARDS) is the most common cause of respiratory failure among critically ill subjects, sepsis and severe bacterial pneumonia being its most common causes. The only interventions that have proven beneficial are protective ventilation strategies and fluid conservation approaches. New therapies are needed to address this common clinical problem. Others and we have previously shown the beneficial effect of infusion of exogenous adult stem cells in different pre-clinical models of ARDS.

Methods
In the present study endotoxin was infused intravenously into 14 sheep from which 6 received different doses of adult stem cells by intrabronchial delivery to evaluate the effect of stem cell therapy.

Results
After administration of endotoxin, there was a rapid decline in oxygenation to hypoxemic values, indicative of severe-to-moderate ARDS. None of the animals treated with saline solution recovered to normal baseline values during the 6 hours that the animals were followed. In contrast, sheep treated with a dose of 40 million adult stem cells returned their levels of oxygen in their blood to baseline two hours after the cells were infused. Similarly, improvements in carbon dioxide (CO2) clearance, pulmonary vascular pressures and inflammation were observed and confirmed by histology and by the decrease in lung edema.

Conclusions
We concluded that instillation of adult non-hematopoietic stem cells can diminish the impact of endotoxin and accelerate recovery of oxygenation, CO2 removal and inflammation in the ovine model, making the use of adult stem cells a real alternative for future therapies for ARDS.
Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signaling
Authors: Zhang Zheng , Zhao Chuanxu , Liu Bing , Liang Dong , Qin Xing , Li Xiujuan , Zhang Rongqing , Li Congye , Wang Haichang , Sun Dongdong , Cao Feng 
Published: March 2014

Abstract
Introduction
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been proposed as an ideal autologous stem cell source for cell-based therapy for myocardial infarction (MI). However, decreased viability and impaired function of aged MSCs hampered the therapeutic efficacy of engrafted MSCs, and the underlying mechanisms remain unclarified. Here, we investigated the role of inositol phosphates 6 kinase (IP6Ks) inhibition on the therapeutic efficacy of BM-MSCs and its underlying mechanism.

Methods
BM-MSCs isolated from young (8-week-old) or aged (18-month-old) donor male C57BL/6 mice, were subjected to hypoxia and serum deprivation (H/SD) injury with or without administration of inositol phosphates 6 kinase (IP6Ks) inhibitor TNP (10 μM). MSC apoptosis induced by H/SD was determined by flow cytometry and TUNEL assays. Protein expressions were evaluated by Western blot assay. Furthermore, the paracrine effects of MSCs were measured by reverse transcriptase–polymerized chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) analyses.

Results
Aged BM-MSCs exhibited more Inositol pyrophosphate 7 (IP7) production, compared with young BM-MSCs. Meanwhile, the expression of phospho-Akt (Thr308) was significantly decreased in the aged MSCs, resulting in enhanced Bad activation and decreased Bax/Bcl-2 ratio. Moreover, the apoptosis in aged BM-MSCs was increased, compared with young BM-MSCs. Furthermore, TNP administration significantly inhibited IP7 production and increased the phosphorylation of Akt under both normoxic and hypoxic conditions. Meanwhile, IP6Ks inhibition reduced apoptotic index of aged MSCs, associated with decreased expressions of pro-apoptotic proteins Bax and Bad and increased anti-apoptotic protein Bcl-2. The expressions of angiogenic factors, including VEGF, bFGF, IGF-1 and HGF, were decreased in MSCs from aged mice. In addition, TNP administration enhanced the paracrine efficiency of aged BM-MSCs under normoxic and hypoxic conditions.

Conclusions
This study demonstrates for the first time that IP6Ks and IP7 play critical role in the aging related vulnerability to hypoxic injury and impaired paracrine efficiency of BM-MSCs, which is associated with impaired Akt activation.
Phase II study of concurrent selective lymph node late course accelerated hyper-fractionated radiotherapy and pemetrexed and cisplatin for locally advanced oesophageal squamous cell carcinoma
Authors: Fu C , Li B , Guo L , Li H , Huang W , Gong H , Sun M , Wang Z , Zhou T , Liu C 
Published: March 2014

Objective:
To determine the clinical efficacy and toxicity of pemetrexed combined with low-dose cisplatin (CDDP) concurrent with late-course accelerated hyperfractionated (LCAF) intensity-modulated radiation therapy (IMRT) in patients with inoperable locally advanced oesophageal squamous cell carcinoma (ESCC).

Methods:
Patients with locally advanced ESCC (less than or equal to 75 years of age, clinical stages IIB–IVA and Karnofsky performance status ≥70) were enrolled into the study. A target group size of 22 was projected based on the estimation that 2-year overall survival (OS) would increase from 20% to 40%. Patients were treated with pemetrexed, low-dose CDDP and LCAF IMRT concurrently. The main objective of the study was for a 2-year OS, and the secondary objectives were progression-free survival (PFS), objective response, locoregional failure rate, and acute and late toxicities.

Results:
25 patients were recruited from October 2008 to July 2011. The median OS was 21 months, with 2- and 5-year OS rates of 44% and 44%, respectively. The median PFS was 18.2 months. The objective response rate was 96% (24/25), with 11 complete responses and 13 partial responses. The locoregional failure rate was 16%. Grades 4 and 5 acute toxicity rates were 8% and 4%, respectively, while no Grade 3 or greater late toxicity was observed.

Conclusion:
The findings of this Phase II study indicated that the therapeutic regimen appears to achieve an excellent response rate and favourable survival for locally advanced ESCC. However, the severe acute side effects should be considered cautiously in further studies.

Advances in knowledge:
To our knowledge, this is the first study that introduced pemetrexed and low-dose CDDP combined with LCAF IMRT to treat locally advanced ESCC. The 5-year OS rate was as high as 44%, which was more favourable than other studies.
The Internet‘s Faustian Bargain
Authors: Barnes Susan B. 
Published: March 2014

Abstract
This Internet probe utilizes Postman’s concept that “all technological change is a Faustian Bargain” to explore online interpersonal relationships. By applying the media ecological concepts of message direction, symbolic form, and the conditions of attendance, this probe discusses the ways in which the Internet’s media environment fosters both positive and negative human behavior patterns.
Reviews
Authors: Albrecht Robert , Petkanas Bill , Zimmer Michael T. , Fallon Peter K. , Leverette Marc , Leverette Marc , Ozersky Josh 
Published: March 2014

Abstract
Bishop, John. Oh What a Blow That Phantom Gave Me. Dir. John Bishop. Prod. John Bishop and Harald Prins. Videocassette. Media Generation/Documentary Educational Resources. 2003. 270 pp. 52 min..
Cavell, Richard. McLuhan in Space: A Cultural Geography. Toronto: University of Toronto Press, 2002. 322 pp. Cloth $65.00, ISBN 0-802-03610-4. Paper $29.95, ISBN 0-802-08658-6.
Crowley, David, and Paul Heyer, eds. Comunication in History: Technology, Culture, Society (4th ed.). Boston: Pearson Allyn and Bacon, 2003. 352 pp. Paper $76.00, ISBN 0-321-08805-0.
Ozersky, Josh. Archie Bunker’s America: TV in an Era of Change, 1968-1978. Carbondale: Southern Illinois University Press, 2003. 194 pp. Cloth $45.00, ISBN 0-80932-507-1.
Heyer, Paul. Harold Innis. Lanham, MD: Rowman & Littlefield, 2003. 176 pp. Cloth $65.00, ISBN 0-742-52483-3. Paper $21.95, ISBN 0-742-52484-1.
Kaha White, C. Media and the Communication Matrix. New York: Peter Lang Publishers, 2003. 193 pp. Paper $24.95, ISBN 0-820-46177-6
Lavery, David, ed. This Thing of Ours: Investigating the Sopranos. New York: Columbia University Press, 2002. 225 pp. Cloth $60.00, ISBN 0-231-12780-4. Paper $17.95, ISBN 0-231-12781-2.
Walking Mornings
Authors: Joyce Michael 
Published: March 2014

Abstract
A highly idiosyncratic and poetic meditation upon attention, this essay considers the phrase, walking mornings, as a complex of possibility framing a reconsideration of technological theories, practices, histories, and futures. Among the many superlatives with which digital culture and commerce bestows itself, the essay claims, we may perhaps add, that never before have human beings been as surrounded as we are now by so much empty possibility. Never before has there been such potentiality harnessed only to displaying itself. In highly personal terms, the essay considers how we might recover a certain necessary silence in the face of a horizon of infinity, how to attend beyond the distractions of the foreground. Walking mornings is a trope for possibility, moving through gathering potentialities, turning and returning toward endlessness within the silence of ourselves.
Reviews
Authors: Cattrysse Patrick , Greer Dr Stephen , Poore Dr Benjamin 
Published: March 2014

Abstract
Translation, Adaptation and Transformation, Laurence Raw (Ed.) (2012) UK: Continuum, 240 pp., ISBN: 9781441157843, h/bk, £67.50
Martin Sherman: Skipping over Quicksand, Trish Dace (2012) Jefferson, NC: McFarland, 345 pp., Print ISBN: 9780786466627, eBook ISBN: 9780786488131, p/bk, $40
Bleak House (BFI TV classics), Christine Geraghty (2012) Basingstoke: Palgrave Macmillan, 139 pp., ISBN: 9781844574179, p/bk, £13.99
A Companion to Literature, Film, and Adaptation, Deborah Cartmell (ed.) (2012) Chichester: Wiley-Blackwell, 433 pp., ISBN: 9781444334975, h/bk, £120.00
Hamlet is Heimat
Authors: Hopkins Lisa 
Published: March 2014

Abstract
This article considers some of the cultural uses made of Hamlet in Edgar Reitz’s two sequels to Heimat (1984), Die Zweite Heimat (1992) and Die Dritte Heimat (2004). A definining characteristic of the young people on whom Die Zweite Heimat focuses is that they are all deeply uneasy about who their elders really are, both in terms of local and specific uncertainties about their own identities and of the wider and all-besetting question of what the older generation did in the war, and whether or not they were Nazis. In Die Dritte Heimat there is again repeated emphasis on father–son relationships, though this time the focus is principally on the destruction or displacement of ‘natural’, biological fatherhood. In turning to Hamlet, a play that German culture has in many ways appropriated as peculiarly its own, Reitz finds a text and a template associated not only with a country that had fought against Nazi Germany but, more fundamentally and more therapeutically, one deeply rooted in an older and far less troubled sense of the German national psyche than any the twentieth century had been able to offer.
Fabricated evidence: Exploring authenticity in a murder mystery’s appropriation of Early Modern drama
Authors: Olive Sarah 
Published: March 2014

Abstract
This article considers instances of scriptwriters (and the protagonist they create) playing with notions of authenticity and revenge tragedy through an episode of the popular murder mystery series Lewis (ITV1, 2011). Parallels between, diversions from and references to the characters, plot structure and setting of Early Modern drama are carefully traced through ‘Wild Justice’. The article argues that authenticity is both established and, to some extent, betrayed by the episode. Its scriptwriter, Stephen Churchett, uses and reinforces Early Modern drama’s cultural and literary value, without being constrained by it. Additionally, by exploring the way in which the programme incorporates the literary into the non-literary, the article extends existing arguments for a positive reconsideration of the sometime-maligned detective genre. Specifically, it adds to previous research arguing that the genre can be regarded as a key source, particularly among television broadcasts and popular fiction, evidencing the continuing cultural value of Early Modern drama.
A tribute to Shakespearean drama in nineteenth-century Spain: The case of Manuel Tamayo y Baus’s Un Drama Nuevo
Authors: Sumillera Rocío G. 
Published: March 2014

Abstract
This article analyses how Shakespearean drama provides the backbone of Un drama nuevo (1867), by the Spanish playwright and academic Manuel Tamayo y Baus (1829-1898). In particular, it considers how characters, themes and dramatic strategies from Shakespeare’s Hamlet, Romeo and Juliet and Othello are incorporated into Un drama nuevo, set in 1605 England and led by the characters of Yorick and Shakespeare. Special focus is given to the play-within-a-play device, the themes of convoluted love intrigues and jealousies, and the confusing interrelation of play (i.e., fiction) and reality, against the background of a discussion of nineteenth-century Spanish drama and the history of the translation and performance of the aforementioned plays by Shakespeare in nineteenth-century Spain.
Multiple makers: The Best Years of Our Lives
Authors: Hoagwood Terence 
Published: March 2014

Abstract
The Best Years of Our Lives (Wyler, 1946), which was the highest-grossing film in the United States after Gone with the Wind (Fleming, 1939), was instantly praised for its realism by Gen. Omar Bradley and by numerous film reviewers. Justly influential scholars and theorists continue to single out this film as an example of realism, the style for which Andre Bazin commended William Wyler (What Is Cinema, 1967). The present article draws upon evidence of three kinds: the film’s production files, including the film-makers’ correspondence about the script; a specific comparison of the film’s narrative content with that of the novel on which the screenplay is based (Glory for Me (1945) by MacKinlay Kantor); and analysis of the cinematography and artistic composition of the film. The present article suggests that the film reverses some of the polemical novel’s central and recurrent meanings. In the interest of stylistic realism, The Best Years of Our Lives includes critique of the artifices of illusion in the consumerist American culture of the post-war years, even while it exploits that artifice and becomes an outstanding example of it. Like the later postmodern parodies that Linda Hutcheon characterizes as ‘complicitous critique’ (The Politics of Postmodernism (1989) by Hutcheon), The Best Years of Our Lives exemplifies the corporate culture that it criticizes. The film’s extreme artificiality achieves the illusion of realism.
Placenta percreta after transcervical myomectomy
Authors: Bøggild Amalie , Langhoff-Roos Jens , Sundberg Karin , Istre Olav 
Published: March 2014

Abstract

Background: Large uterine fibroids and placenta percreta are often associated with a hysterectomy.

The case: A 31-year-old nulligravida had a transcervical resection of a large fibroid (158 g) in the anterior wall of the uterus. A subsequent spontaneous pregnancy was complicated by placenta percreta. In late pregnancy, she had an elective cesarean section, the percrete area was resected, and she had an abdominal cerclage for hemostasis and support. Subsequently, she had two term pregnancies with normal placentation.

Conclusion: The woman avoided hysterectomy twice, first for gynecological and second for obstetrical reasons – and had three healthy infants. We conclude that the uterus should be preserved whenever possible in young fertile women.
Sintering Temperature-Dependent Chemical Defects and the Effect on the Electrical Resistivity of Thermoelectric ZnO
Authors: Zhao Yu , Kumar Ashok , Khodaparast Giti A. , Eltahir Amnah , Wang Hsin , Priya Shashank 
Published: March 2014

Abstract
Thermoelectric properties of zinc oxide (ZnO) are largely influenced by its electrical property. In this paper, we investigated the correlation between the electrical resistivity and synthesis temperature for aluminum (Al)-modified ZnO. At constant Al doping, the electrical resistivity of ZnO exhibited sharp decrease with increase in sintering temperature due to the increased carrier density resulting from Al3+ substitution on Zn2+ sites. Photoluminescence analysis showed that segregation of Al in secondary phase, ZnAl2O4, promotes Zn2+ vacancy formation and consequently compensates the free electrons that dominate the electrical behavior at relatively low sintering temperature. The mechanism controlling the large change in electrical resistivity of dense ZnO, ranging from insulator (~107 Ω cm) to semiconducting regime (~ 0.1 Ω cm) has been discussed.
On the Fitting height of factorised soluble groups
Authors: Casolo Carlo , Jabara Enrico , Spiga Pablo 
Published: March 2014

Abstract
In this paper we are concerned with finite soluble groups G admitting a factorisation

G
=
A
B

${G=AB}$

, with A and B proper subgroups having coprime order. We are interested in bounding the Fitting height of G in terms of some group-invariants of A and B, including the Fitting heights and the derived lengths.
On Brauer indecomposability of Scott modules of Park-type groups
Authors: Tuvay İpek 
Published: March 2014

Abstract
Let p be a prime number, G be a
finite group, P be a p-subgroup of G, and k be an
algebraically closed field of characteristic p.
We prove that the k
G-Scott module with vertex
P is Brauer indecomposable for some families of
groups closely related to groups constructed by
Park in the context of fusion systems.
Crystal structure of 2,3-bis(3'-methylthiophene-5'-carbaldehyde-2-yl) thiophene, C16H12O2S3
Authors: Li Xiaochuan , Jiang Wenjuan , Son Young-A 
Published: March 2014

Abstract C16H12O2S3, orthorhombic, Pbcn (no. 60), a = 10.8457(4) Å, b = 8.1000(3) Å, c = 17.6048(6) Å, V = 1546.6 Å3, Z = 4, Rgt(F) = 0.0401, wRref(F2) = 0.0953, T = 296 K.
Crystal structure of trans-dichloridotetrakis(thiourea-κS)manganese(II), C4H16Cl2MnN8S4
Authors: Chen Lijuan , Xu Xiaohui 
Published: March 2014

Abstract C4H16Cl2MnN8S4, tetragonal, P42/n (no. 86), a = 13.7526(9) Å, c = 9.0785(9) Å, V = 1717.1 Å3, Z = 4, Rgt(F) = 0.0294, wRref(F2) = 0.0877, T = 290 K.
Monitoring Setting of Geopolymers
Authors: Suraneni Prannoy , Puligilla Sravanthi , Kim Eric H. , Chen Xu , Struble Leslie J. , Mondal Paramita 
Published: March 2014

AbstractThe setting behavior of geopolymer pastes as a function of time was studied using two methods: penetration resistance and ultrasonic shear wave reflection. Several starting materials were included—metakaolin, Class C and Class F fly ashes, and slag—and chemical parameters known to affect set were varied. The geopolymers showed a wide range of set times compared to a reference Portland cement paste: some were much more rapid, some were similar, and some were much slower. Although most geopolymers formed gels that were both solid and had measurable strength, some, initially, formed a soft gel that had no measurable strength. Therefore, to fully characterize setting behavior, it is necessary to use both types of tests. It was seen that setting behavior was sensitive to chemical parameters, with setting delayed somewhat with increasing silica/alumina and increasing water/alkali, and accelerated substantially with calcium hydroxide substitution.
Determining Coefficients of Thermal Contraction and Expansion of Asphalt Concrete Using Horizontal Asphalt Strain Gage
Authors: Islam Md Rashadul , Tarefder Rafiqul A. 
Published: March 2014

Abstract
Thermal strain occurs in asphalt pavement from thermal contraction and expansion due to temperature decrease and increase, respectively. No standard procedure to measure thermal strain is available. This study determines thermal strain per unit increase or decrease in temperature (also referred to as coefficient of thermal contraction or thermal expansion (CTC or CTE)) in an instrumented pavement section on Interstate 40 (I-40) in New Mexico. Firstly, the Horizontal Asphalt Strain Gages (HASGs) are calibrated for temperature to measure thermal strain. In the second step, the thermal strain variations in fall, winter, and summer are determined. For validation, the CTC and the CTE values are measured in the laboratory on three field collected cylindrical cored samples using Linear Variable Displacement Transducers (LVDTs) and temperature sensors. The LVDTs are also calibrated using a cylindrical zerodur block to account the temperature effect on it. Results show that field CTC and CTE values are close to the laboratory findings.
Polygyny Increases Survival of Minor Workers and Mortality of Major Workers in OverwinteringCamponotus yamaokai(Hymenoptera: Formicidae)
Authors: Shiroto Akiyoshi , Satoh Toshiyuki , Hirota Tadao 
Published: March 2014

AbstractA higher proportion of polygynous ant species in northern areas suggests that cold climates select for increased queen number per colony. However, the types of social conditions within nests that allow polygynous species to inhabit cold climates are unclear. The Japanese twig-dwelling ant, Camponotus yamaokaiTerayama & Satoh, 1990, which has on average two queens per colony, also inhabit colder areas than monogynous related species. C. yamaokai alates remain in natal colonies and always overwinter with workers. A previous study demonstrated that cohabitation by workers facilitates overwintering success of C. yamaokai queens. However, how queen number influences the survival of queens cohabitating with workers and the survival of other castes was not investigated. Here, we compared overwintering survival of queens and workers among experimental groups with different social structures. Wintering experiments revealed that queen survival did not differ between monogynous (one queen) and polygynous (two queens) groups but was correlated positively with worker number. Meanwhile both queen and worker number influenced worker survival, and these factors interacted with worker type (minor or major). Worker survival increased with increasing worker number, but the effect was more pronounced for major workers than for minor workers. With respect to queen number, minor workers survived longer in polygynous groups than in monogynous groups, whereas the opposite pattern was found in major workers. In other words, major worker mortality increased with increasing queen number. These results suggest that cohabitation with workers but not other queens facilitates queen survival, and that queen number increases survival in minor workers but increases mortality in major workers. Possible explanations for this latter pattern are discussed.