bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial Effects of Coenzyme Q10 in Reduction of Testicular Tissue Alteration Following Induction of Diabetes in Adult Rats
Authors: Kianifard Davoud , Rezaee Farhad 
Published: May 2015

Abstract
Background and Aims: Various types of infertility are associated with uncontrolled hyperglycemia and diabetes. Development of oxidative stress is one the most important factors in the alteration of spermatogenesis in diabetic conditions. Consequently, the reduction of oxidative stress with antioxidant compounds can be effective in the reduction of tissue alterations. The aim of this study was to evaluate the efficacy of coenzyme Q10 in improvement of spermatogenesis in adult diabetic rats. Material and Methods: 32 adult rats were divided into four groups of control and treatment. Coenzyme Q10 (10 mg/kg body weight - b.w.) was administrated to one control and one diabetic (intraperitoneal injection of 45 mg/kg b.w. of Streptozotocin) groups. Blood concentrations of FSH, LH and Testosterone were measured. Histology of testicular tissue and sperm analysis were considered for evaluation of spermatogenesis. Results: Administration of Coenzyme Q10 led to increase of pituitary gonadotropins levels in diabetic rats. Testosterone levels were not changed significantly. Testicular morphology, spermatogenic indices and sperm analysis were improved in treated diabetic rats. Conclusions: The results of this study suggest that the use of Coenzyme Q10 has positive effects in reduction of spermatogenic alterations following induction of experimental diabetes in rats.
The Importance of Postprandial Hyperglycemia Position Statement of the Danube Mco Experts
Authors: Barkai László , Hâncu Nicolae , Jermendy György , Konstantinova Maya , Lichiardopol Radu , Moţa Maria , Tankova Cvetalina , Temelkova Natalia , Winkler Gábor 
Published: May 2015

Abstract
Both the prevalence and incidence of type 2 diabetes are increasing worldwide and over 60% of people with T2DM develop cardiovascular disease. There are many data supporting the view that glycaemic control plays a role in reducing cardiovascular complications. The relationship between hyperglycaemia and cardiovascular disease is complex with evidence suggesting that an acute increase of glycaemia, particularly after a meal, may have a direct detrimental effect on cardiovascular disease. Although control of fasting hyperglycaemia is necessary, it is usually insufficient to obtain optimal glycaemic control. A growing body of evidence suggests that reducing post meal plasma glucose excursions is as important, or perhaps more important for achieving HbA1c goals. New classes of therapies for managing post meal plasma glucose in people with diabetes (glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors) have shown significant benefits in reducing post meal plasma glucose excursions andlowering HbA1c. The individual properties of the various GLP‑1 receptor agonists might enable incretin-based treatment of type 2 diabetes mellitus to be tailored to the needs of each patient.
Surgery of petroclival meningiomas. Recent surgical results and outcomes
Authors: Radoi Mugurel , Stefanescu Florin , Vakilnejad Ram , Gheorghitescu Lidia , Rosu Daniela 
Published: May 2015

Abstract
Petroclival meningiomas represent only 10% of all meningiomas located in the posterior fossa, but are some of the most formidable challenges in skull base surgery. We described our recent experience (2005-September2014) regarding the surgery of these tumors. We retrospectively analyzed surgical results and outcome in 11 cases of petroclival meningiomas. Most common symptoms in our series were headache and gait disturbance, while cranial nerves palsies represented the most common presenting signs. There were 8 females and 3 males, and the mean age was 52 years. Surgical approaches chosen for petroclival meningiomas in our series were retrosigmoid (9 patients) and subtemporal transtentorial (2 patients). We achieved total tumor resection in 5 cases (45%) and subtotal resection in 6 cases (55%). Overall outcome (total/subtotal resection) was good in 6 cases, fair in 3 cases and poor in one case. One postoperative death occurred due to hemorrhagic midbrain infarction (9%). Complications were usually related to cranial nerve deficits: loss of hearing (2 patients), paresis of trochlear nerve (1 patient), trigeminal nerve (3 patients) and facial nerve (1 patient). In 4 patients these cranial nerves deficits were transient. In one case, a patient developed postoperative hydrocephalus and needed shunt placement. Despite the fact that complications can be disastrous, we considered that an appropriate approach, combined with microsurgical techniques and a better understanding of the anatomy, greatly decrease the incidence and severity of complications and make feasible a total tumor resection.
On traumatic brain injury epidemiological data collected from a county hospital in Romania and an estimation of psychiatric consequences thereof
Authors: Mittler-Matica Roxana 
Published: May 2015

Abstract
Introduction: Many aspects justify the increasing attention upon TBI and post TBI sequels. Material and Methods: The paper resumes statistics on traumatic brain injury (TBI) from a Romanian country district, collected throughout five years. Statistics in the literature that demonstrated the link between TBI and psychiatric disorders are extrapolated. Results: TBI is considered to be a risk factor for psychiatric disorders. As consequence, estimation of some post TBI psychiatric sequels is computed aiming to emphasize the need for psychiatric support and treatment in more organized multidisciplinary neuro-trauma management teams. Conclusions: TBI is considered to be a risk factor for psychiatric disorders which are a major cause of post TBI disability. The size of these psychiatric sequels in accordance with the existing literature can be approximated in a given population. TBI epidemiology analysis reveals hazardous impact on the overall health condition of patients.
Spontaneous intracranial hemorrhage in children – ruptured lobar arteriovenous malformations: report of two cases
Authors: Tascu A. , Pascal C. , Florea S.M. , Iencean St.M. 
Published: May 2015

Abstract
Brain arteriovenous malformations (AVMs) are lesions thought to be primarily congenital in origin, consisting of fistulous connections of abnormal arteries and veins, without normal intervening capillary beds and no cerebral parenchyma between vessels. In the pediatric population, AVMs represent the most common cause of spontaneous intracranial hemorrhage (ICH), with a high recurrent bleeding risk. The aim of this paper is to report 2 cases of ruptured lobar AVMs in children, presenting with spontaneous ICH. Due to the patients’ neurological status, the only imaging examination performed preoperatively was a CT scan, showing intraparenchymal hemorrhage. Thus, there was no MRI/angiographic examination to prove the existence of a brain AVM prior to the surgical interventions. Also, the cerebral angiography performed after the surgery showed, in both patients, no signs of residual vascular malformations. Therefore, the diagnosis of AVM was certified by macroscopic and microscopic pathological findings, with no brain imaging suggestive of a vascular malformation.
Appearance of isolated thrombocytopenia in a patient of acute subdural hematoma
Authors: Kumar S. Satish , Srinivas M. , Raghu K. , Shashidhar P. , Agrawal Amit 
Published: May 2015

Abstract
Thrombocytopenia in critically ill patients probably reflects the severity of the underlying illness and these patients have a higher mortality due to the severity of overall clinical status. In present article we report a case of acute subdural hematoma who developed progressive thrombocytopenia resulting in fatal outcome. A 75 year gentleman presented with history of sudden onset headache and lapsed into altered sensorium. There was history of trivial fall before he developed headache. The patient was deeply comatose with pupils bilateral 2 mm and reacting to light. Computerized tomography (CT) scan brain showed large right fronto-temporo-parietal acute subdural hematoma with mass effect and midline shift. Post-operatively he was kept on elective ventilation. On following days the patient continues to develop thrombocytopenia (Day- 3 Platelet count 75,000, day-4 60,000, day-5 25,000). Thrombocytopenia is a common but a potentially life-threatening condition problem and has been considered to play a role in worsening the prognosis of critically ill patients in intensive care unit. Few studies statistically examine the strength of the association between risk factors and outcomes related to thrombocytopenia, additional research is recommended to identify putative molecular determinants.
Post Traumatic Glioma – An association questioned
Authors: Chaurasia I.D. , Chaudhary Arpan , Verma Nitin , Chaurasia Ishant Kumar , Koshariya Mahim , Songra M.C. 
Published: May 2015

AbstractPost traumatic glioma has been a matter of debate. Few reports favor its occurrence in previous head injury scar, subsequently developing into glioma. Here we report a case of young patient presented with headache, seizures and gradual loss of vision. On investigation found to have brain tumor. Patient had head injury occurred 3 yrs back. It fulfills all the criteria required to establish traumatic origin, further supporting the association.
Organizational Principles and Content of Early Foreign Language Learning in the USA
Authors: Biletska Iryna 
Published: May 2015

Abstract According to the results of leading American scientists that convincingly demonstrate the effectiveness and necessity of early foreign language learning the features of teaching foreign languages at elementary level in the United States have been analyzed. It has been found out that the US government is working on the improvement of foreign language at elementary education all over the country. The attention is paid the languages that were not so popular, and now have obtained the status of “extremely necessary”, such as Arabic, Farsi and Russian, as they have become very important for the future participation of the state in world politics. The requirements for programs development of foreign language for elementary school have been described; such aspects as quantity of classes, curriculum project, teaching materials, teaching staff and knowledge of the students, the choice of languages, coordination and efficiency are taken into consideration. The short description of the content of foreign language teaching of elementary education has been presented. It has been indicated that success in foreign language learning as a device of foreign language communication depends on the level of listening, lexical, grammatical and spelling skills, as well as the abilities of listening, speaking, reading and writing, which are defined in the program for elementary school.
Theoretical Framework of Leadership in Higher Education of England and Wales
Authors: Mukan Nataliya , Havrylyuk Marianna , Stolyarchuk Lesia 
Published: May 2015

Abstract In the article the theoretical framework of leadership in higher education of England and Wales has been studied. The main objectives of the article are defined as analysis of scientific and pedagogical literature, which highlights different aspects of the problem under research; characteristic of the theoretical fundamentals of educational leadership, and presentation of classification of leadership models in educational sphere. Leadership in higher education has been studied by foreign and domestic scientists: methodology of comparative education (C. Bargh, N. Bidyuk, N. Mukan, A. Sbruyeva); continuous professional education (J. Barge, A. Kuzminskyy, N. Nychkalo, P. Lorange); leadership in education (J. Bareham, L. Danylenko, L. Karamushka, N. Kolominskyy, O. Marmaza); leaders’ training (A. Borysova, V. Ilromovyy) etc. In Ukraine this problem has not been studied yet. The research methodology comprises theoretical (comparative and historical method, logical method, analysis and synthesis), and applied (conversations and dialogues) methods. The research results have been presented: the comprehensive integration of leadership theories in the sphere of philosophy, sociology, psychology, pedagogy, management has been justified; the definition of leadership and distributed leadership, and their characteristic have been provided; the leadership models in higher education of England and Wales have been determined.
Literary Competence of Future Philology Teachers’ Professional Development (Based on the Educational Experience of Germany)
Authors: Bazyl Ludmyla 
Published: May 2015

Abstract The author performs a theoretical analysis of the educational experience in philology teachers’ professional training in Germany in the context of solving scientific problem of literary competence development. Internal and external factors of this process have been determined both by socio-political realities, economic, philosophical, cultural, psychological factors, and the dynamics of the literary process in developed countries, content diversity of literary studies, methodological, aesthetic, methodological factors of mastering literature process have been emphasized. Particular attention has been paid to designing strategies for studying modern literature based on Bourdieu’s theory providing a detailed understanding of specific contexts and holistic understanding of the literary field due to metadiscourse analysis. Through the use of empirical data the process of literary field theory establishing in the German literature study has been explained, attention has been focused on reviewing the G. Grass’ latest novel by literary critics under the influence of external and internal factors of literary process development that specifies educational process of literary competence development.
The Formation of Future Socionomic Experts’ Conflictological Culture in Germany and Austria
Authors: Branitska Tetiana 
Published: May 2015

Abstract At the present stage of Ukrainian society development there is a requirement for studying and the analysis of the maintenance of experts’ preparation in social, socially pedagogical sphere in foreign countries. Therefore the great value has research of experience in theoretical and practical preparation of the future socionomic experts in the universities of Germany and Austria. In the article the formation of socionomic future experts’ conflictological culture and teaching features of social-pedagogically directed disciplines in high schools of Germany and Austria have been considered. The analysis of the scientific and pedagogical literature devoted to studying separate aspects of socionomic experts’ conflictological culture formation has been carried out. The standard-legal maintenance of future social teachers’ vocational training in high schools of Germany and Austria, in particular, features of curricula, their substantial filling, and also training specificity have been investigated. Presence of the conflictological component in the frame of future socionomic experts’ preparation has been designated, that allows students to raise efficiency of professional work in the future. Improvement of the programs and subject content able to open peculiarities of future socionomic experts’ psychological pedagogical and conflictological preparation in Germany and Austria will promote formation of the modern competitive expert with a high level of conflictological culture.
Medical Informatics Specialty in the Developed English-Speaking Countries: the Terminology Comparative Analysis
Authors: Kobryn Nadia 
Published: May 2015

Abstract The article studies the development process of medical informatics specialty terminology as the ground for further research into foreign countries’ experience, including the Canadian one, of specialists’ professional training in the field of MI. The study determines the origin and chief stages of the formation and development of the medical informatics terminological system. The author performs the comparative analysis of terms used by the world organizations on health care informatisation issues, particularly International Medical Informatics Association as well as medical informatics associations of the USA and Canada as the leading countries where qualified workforce in the medical informatics specialty is trained. The European and Ukrainian experience has also been taken into consideration. The results of the comparative study have shown that the English terms ‘medical informatics’, ‘biomedical informatics’ and ‘health informatics’ serve as the umbrella terms for professional training programs and include a set of subspecialties that identify diverse spheres of information technology applications to medical science and practice, namely ‘clinical informatics’, ‘bioinformatics’, ‘health care informatics’, ‘nursing informatics’, ‘imaging informatics’, etc.
Primary Teachers’ Professional Training in the System of Postgraduate Education in the Light of Differentiating Teaching: Irish Experience
Authors: Gotsuliak Kateryna 
Published: May 2015

Abstract Different information sources, namely National Strategy for Higher Education to 2030 (Ireland), Introduction to Primary School Curriculum (1999), (Ireland), Primary Professional Development Service - Differentiation in Action, Ireland’s official postgraduate study website, the Strategic Plan 2012-2016 of Mary Immaculate College, Limerick University), have been studied. The mission of primary education in the light of differentiating teaching has been indicated. Main aspects of differentiating teaching have been highlighted. The correspondence between differentiating teaching foundations and primary school curriculum has been proved. Irish experience in professional training of future primary teachers in the system of postgraduate education in the light of differentiating teaching has been analyzed. Due to theoretical analysis of Professional Master of Education (Primary Teaching) (PME) postgraduate course’s aims the priority tasks of future primary teachers have been defined. Peculiarities of the postgraduate course of the Professional Master of Education (Primary Teaching) at Mary Immaculate College, University of Limerick have been justified. Positive aspects of Irish experience in postgraduate education system, in particular professional training of primary teachers, have been defined. Perspectives for the Ukrainian postgraduate system as for professional training of primary teachers have been outlined.
Is nitrate a good biomarker of the nitric oxide status? / Este ionul nitrat un bun biomarker al producţiei endogene de monoxid de azot?
Authors: Croitoru Mircea Dumitru , Fülöp Ibolya , Fogarasi Erzsébet , Muntean Daniela-Lucia 
Published: May 2015

AbstractA method of measuring in vivo nitric oxide (NO) levels is required to detect pathological conditions in which endogenous production is decreased or to identify agents able to release this biomolecule. Unfortunately, nitric oxide has a very short biological half-life and is very difficult to measure. Assay of the oxidative products’ of NO levels, nitrite (NORabbits were used as experimental animals, a validated HPLC-UV/VIS method was used for speciation of nitrite and nitrate. The following substances were administered: blank; “negative blank”: phenyl-N-tert-butylnitrone (PBN); “positive blank” (nitroglycerin); nitrite.PBN administration significantly increased nitrate and decreased nitrite levels, nitrite administration excessively increased nitrate levels, while nitroglycerin (1 mg/kg) significantly increased both nitrate and nitrite levels.Results show that NOx test cannot be considered accurate in acute nitric oxide status testing. Nitrite alone should be used as an in vivo released nitric oxide marker.
Serum erythropoietin level in anemia of chronic kidney disease - experience of a Romanian medical centre / Nivelul eritropoietinei serice în anemia din boala renală cronică - experiența unui centru medical românesc
Authors: Pop Nicoleta Dora , Bacârea Anca , Coroș Ligia , Dogaru Grigore Aloiziu , Hosu Ioan , Bacârea Vladimir , Nagy Attila 
Published: May 2015

AbstractIn this study, different aspects of anemia in chronic kidney disease have been observed, starting from the fact that the severity of anemia is associated with the degree of kidney dysfunction, the main cause being the erythropoietin deficiency, which is synthesized mostly by the kidneys. 58 persons were included in this study, 19 patients with non-dialysis-dependent chronic kidney disease, 18 patients with chronic kidney disease who received kidney transplantation and 21 apparently healthy persons. We evaluated the serum level of erythropoietin, serum creatinine, proteinuria, the glomerular filtration rate, the erythrocyte parameters and the correlations between them. The prevalence of anemia in patients with chronic kidney disease was of 51.35%. The hemoglobin concentration in patients with kidney transplantation (12.4 ± 2.7 g/dL) and in non-dialysis-dependent patients (11.7 ± 1.4 g/dL) is significantly different compared to the apparently healthy persons (14.6 ± 0.8 g/dL) (p<0.05). In the case of the non-dialysis-dependent patients who were not treated with erythropoiesis- stimulating agents we found positive associations between the glomerular filtration rate and the number of erythocytes (r = 0.71), hemoglobin (r = 0.65) and hematocrit (r = 0.73), as well as negative associations between creatinine and the number of erythrocytes (r = -0.72), hemoglobin (r = -0.86) and hematocrit (r = -0.88). In patients with kidney transplantation and anemia we observed positive correlations between erythropoietin and the number of erythrocytes (r = 0.69), between the glomerular filtration rate and the number of erythrocytes (r = 0.78) and erythropoietin (r = 0.97), as well as negative correlations between proteinuria and the number of erythrocytes (r= -0.89), hemoglobin (r= -0.72), hematocrit (r = -0.72), and erythropoietin (r = -0.67), and between creatinine and the number of erythrocytes (r = -0.75) and erythropoietin (r = -0.86).
The efficiency of sodC gene / N. meningitidis detection in comparison with the classical methods for the diagnosis of meningococcal infection / Evaluarea eficienţei Real Time PCR TaqMan utilizând gena sodC / N. meningitidis în comparaţie cu metodele clasice utilizate în diagnosticul infecţiei meningococice
Authors: Nemescu Roxana Elena , Ursu Ramona Gabriela , Dorobăț Carmen Mihaela , Iancu Luminița Smaranda 
Published: May 2015

AbstractMeningococcal infection requires a fast and accurate diagnostic method in order to correctly initiate the antibiotic therapy. The aim of our study was to assess the efficiency of Real Time PCR -Taq Man using sod C gene / N. meningitidis in comparison with the classical methods for the diagnosis of meningococcal infection - direct microscopy, cultivation, latex agglutination and blood culture. We have detected 24/44 (54.54%) patients with meningococcal infection. In both cases of patients with / without previous antibiotic therapy before admission, the AUC (area under curve) had the highest values for RT PCR in CSF and blood analysis. This sod C RT-PCR assay is a highly sensitive and specific method for detection of Neisseria meningitis and it would be useful to include this method like a multiplex in routine testing of patients with clinical meningococcal infection for other etiological agents also.