bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 2.84 Mb deletion at 21q22.11 in a patient clinically diagnosed with marden–walker syndrome
Authors: Carrascosa‐Romero María Carmen , Suela Javier , Pardal‐Fernández José Manuel , Bermejo‐Sánchez Eva , Vidal‐Company Alberto , MacDonald Alexandra , Tébar‐Gil Roque , Martínez‐Fernández María Luisa , Martínez‐Frías María Luisa 
Published: July 2013

AbstractWe present a girl with the characteristic clinical picture associated with Marden–Walker syndrome (MWS; OMIM 248700), including mask‐like face with blepharophimosis, joint contractures, intellectual disability, a multicystic dysplastic kidney and cerebral dysgenesis. The long‐term follow‐up allowed us to monitor the evolution of the phenotype in this patient, and among the main findings we highlight the following: demyelination of the pyramidal tract demonstrated by transcranial magnetic stimulation and the involvement of the levator muscles of angle of mouth in fixed facial expression with relative integrity of the rest of the facial expression muscles. A 244 k array comparative genomic hybridization (aCGH) was carried out and showed a de novo interstitial deletion of approximately 2.84 Mb affecting only the cytoband 21q22.11 (genome coordinates chr21:31,874,016–34,711,763). We selected 10 of the most recent published cases with either total or partial deletions of cytoband 21q22.11 that provided good characterization of the genomic size or the genes in the deleted regions. We observed that in nine of the 10 cases the deleted regions included the RUNX1 gene in 21q22.12, which is not affected in the current patient's deletion or in that of Patient 3 from Roberson et al. [2011]. After a comparison of shared deleted genes between cases, and correlation of their potential phenotypes, we concluded that the pattern of defects considered for a diagnosis of MWS may represent part of the phenotypic expression of a partial or total deletion of 21q22.11. © 2013 Wiley Periodicals, Inc.
Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003
Authors: Sauber‐Schatz Erin K. , Bodnar Lisa M. , Weiss Harold B. , Wilson John W. , Pearlman Mark D. , Markovic Nina 
Published: July 2013

BACKGROUNDCase reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system–related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy.METHODSThrough a case–control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999–2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy.RESULTSOf the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63–1.56 and 2.44; 95% confidence interval, 1.08–5.53 among breech presentation infants. Probabilistic bias analysis supported these findings.CONCLUSIONNo association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A) 97:641–648, 2013. © 2013 Wiley Periodicals, Inc.
Allogeneic cell therapy bioprocess economics and optimization: Single‐use cell expansion technologies
Authors: Simaria Ana S. , Hassan Sally , Varadaraju Hemanthram , Rowley Jon , Warren Kim , Vanek Philip , Farid Suzanne S. 
Published: July 2013

ABSTRACTFor allogeneic cell therapies to reach their therapeutic potential, challenges related to achieving scalable and robust manufacturing processes will need to be addressed. A particular challenge is producing lot‐sizes capable of meeting commercial demands of up to 109 cells/dose for large patient numbers due to the current limitations of expansion technologies. This article describes the application of a decisional tool to identify the most cost‐effective expansion technologies for different scales of production as well as current gaps in the technology capabilities for allogeneic cell therapy manufacture. The tool integrates bioprocess economics with optimization to assess the economic competitiveness of planar and microcarrier‐based cell expansion technologies. Visualization methods were used to identify the production scales where planar technologies will cease to be cost‐effective and where microcarrier‐based bioreactors become the only option. The tool outputs also predict that for the industry to be sustainable for high demand scenarios, significant increases will likely be needed in the performance capabilities of microcarrier‐based systems. These data are presented using a technology S‐curve as well as windows of operation to identify the combination of cell productivities and scale of single‐use bioreactors required to meet future lot sizes. The modeling insights can be used to identify where future R&D investment should be focused to improve the performance of the most promising technologies so that they become a robust and scalable option that enables the cell therapy industry reach commercially relevant lot sizes. The tool outputs can facilitate decision‐making very early on in development and be used to predict, and better manage, the risk of process changes needed as products proceed through the development pathway. Biotechnol. Bioeng. 2014;111: 69–83. © 2013 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc.
Coupling dark metabolism to electricity generation using photosynthetic cocultures
Authors: Badalamenti Jonathan P. , Torres César I. , Krajmalnik‐Brown Rosa 
Published: July 2013

ABSTRACTWe investigated the role of green sulfur bacteria inlight‐responsive electricity generation in microbial electrochemical cells (MXCs). We operated MXCs containing either monocultures or defined cocultures of previously enriched phototrophic Chlorobium and anode‐respiring Geobacter under anaerobic conditions in the absence of electron donor. Monoculture control MXCs containing Geobacter or Chlorobium neither responded to light nor produced current, respectively. Instead, light‐responsive current generation occurred only in coculture MXCs. Current increased above background levels only in the dark and declined slowly over 96 h. This pattern suggested that Chlorobium exhausted intracellular glycogen reserves via dark fermentation to supply an electron donor, presumably acetate, to Geobacter. With medium containing sulfide as the sole photosynthetic electron donor, current generation had a similar and reproducible negative light response. To investigate whether this metabolic interaction also occurred without an electrode, we performed coculture experiments in batch serum bottles. In this setup, sulfide served as the sole electron donor, whose oxidation by Chlorobium was required to provide S0 as the electron acceptor to Geobacter. Copies of Geobacter 16S rDNA increased approximately 14‐fold in batch bottle cocultures containing sulfide compared to those lacking sulfide, and did not decline after termination of sulfide feeding. These results suggest that products of both photosynthesis and dark fermentation by Chlorobium were sufficient both to yield an electrochemical response by Geobacter biofilms, and to promote Geobacter growthin batch cocultures. Our work expands upon the fusion of MXCs with coculture techniques and reinforces the utility of microbial electrochemistry for sensitive, real‐time monitoring of microbial interactions in which a metabolic intermediate can be converted to electrical current. Biotechnol. Bioeng. 2014;111: 223–231. © 2013 Wiley Periodicals, Inc.
Application of the adhesive bacterionanofiber AtaA to a novel microbial immobilization method for the production of indigo as a model chemical
Authors: Ishikawa Masahito , Shigemori Kazuki , Hori Katsutoshi 
Published: July 2013

ABSTRACTThe toluene‐degrading bacterium Acinetobacter sp. Tol 5 shows high adhesiveness mediated by the bacterionanofiber protein AtaA, which is a new member of the trimeric autotransporter adhesin (TAA) family. In contrast to other reported TAAs, AtaA mediates the adhesion of Tol 5 to various abiotic surfaces ranging from hydrophobic plastics to hydrophilic glass and stainless steel. The expression of ataA in industrially relevant bacteria improves their adhesiveness and enables immobilization directly onto support materials. This represents a new method that can be alternated with conventional immobilization via gel entrapment and chemical bonding. In this study, we demonstrate the feasibility of this immobilizing method by utilizing AtaA. As a model case for this method, the indigo producer Acinetobacter sp. ST‐550 was transformed with ataA and immobilized on a polyurethane support. The immobilized ST‐550 cells were transferred directly to a reaction solution containing indole as the substrate. The immobilized ST‐550 cells showed a faster indigo production rate at high concentrations of indole compared with planktonic ST‐550 not expressing the ataA gene, implying that immobilization enhanced the tolerance of ST‐550 to the substrate indole. As a result, the immobilized ST‐550 produced fivefold higher levels of indigo than planktonic ST‐550. These results proved that AtaA is useful for bacterial immobilization. Biotechnol. Bioeng. 2014;111: 16–24. © 2013 Wiley Periodicals, Inc.
Ruthenium‐Catalyzed Transfer‐Hydrogenative Cyclization of 1,6‐Diynes with Hantzsch 1,4‐Dihydropyridine as a H2 Surrogate
Authors: Yamamoto Yoshihiko , Mori Shota , Shibuya Masatoshi 
Published: July 2013

AbstractThe transfer‐hydrogenative cyclization of 1,6‐diynes with Hantzsch 1,4‐dihydropyridine as a H2 surrogate was performed in the presence of a cationic ruthenium catalyst of the type [Cp′Ru(MeCN)3PF6]. Exocyclic 1,3‐dienes or their 1,4‐hydrogenation products, cycloalkenes, were selectively obtained, depending on the substrate structure and the reaction conditions.
ChemInform Abstract: Triflic Acid Mediated Fries Rearrangement of 3‐Dienyl‐azetidinones: Facile Synthesis of 3‐(But‐2‐enylidene)quinolin‐4(3H)‐ones.
Authors: Anand Amit , Mehra Vishu , Kumar Vipan 
Published: July 2013

AbstractTreatment of β‐lactams (I) with TfOH results in a ring‐opening/ring‐closing isomerization to provide the target compounds in moderate yields.
ChemInform Abstract: Evaluation of Efficiency of Chiral Atropisomeric Phosphorus Ligands in the Asymmetric Catalytic Processes Mediated by Transition Metal Complexes. Part 1. Evaluation of Steric Effects
Authors: Demchuk Oleg M. , Lastawiecka Elzbieta , Pietrusiewicz K. Michal 
Published: July 2013

AbstractReview: 49 refs.
Adsorption of chromium(VI) metal ions from aqueous solution using hexagonal ZnO particles: Equilibrium, kinetic and thermodynamic modelling studies
Authors: Erduran Nuran , Gökgöz Murat , Ada Kezban 
Published: July 2013

AbstractZinc oxide powders having hexagonal plate particles were prepared by homogeneous precipitation from boiling aqueous solutions that contained excess urea and 0.075 (Z075) and 0.300 (Z300) M Zn2+. The equilibrium, kinetic and thermodynamics of the adsorption of chromium (VI) from aqueous solution onto Z075 and Z300 were investigated. Thermodynamic parameters and K# equilibrium constant of activation were calculated. Langmuir, Temkin and Dubinin–Radushkevich (D–R) isotherm models were used to describe the adsorption of Cr(VI) onto ZnO powders. The monomolecular adsorption capacity of Z075 and Z300 was determined as 980 and 1050 mg g−1 for Cr(VI), respectively.
Molecularly imprinted β‐cyclodextrin/Kaoline particles for the selective recognition and binding of bisphenol A
Authors: Xie Qingjie , Li Linzi , Pan JianMing , Meng Minjia , Song Zhilong , Zhu Wenjing , Wang Bing , Yu Ping 
Published: July 2013

AbstractMolecularly imprinted β‐cyclodextrin/Kaoline particles (MIPs) were prepared for recognitive adsorption of bisphenol A (BPA) from aqueous solution. The characterisation of MIPs were achieved by FTIR spectra, SEM micrographs, nitrogen adsorption–desorption analysis and elemental analysis. The equilibrium data, at various temperatures, were described by the Langmuir, Freundlich and Dubinin‐Radushkevich isotherm models. The kinetic properties were successfully investigated by pseudo‐first‐order model, pseudo‐second‐order model, intraparticle diffusion equation, initial adsorption rate and half‐adsorption time. Based on the comparison of diffusion parameters, including intraparticle diffusion, film diffusion and pore diffusion, we can confirm the process of recognitive binging sites in MIPs. A diffusion‐controlled process as the essential adsorption rate‐controlling step was proposed. Moreover, intraparticle diffusion increased with BPA concentration while film and pore diffusion decreased. An increase in the temperature was found to increase intraparticle and pore diffusion, and reduce film diffusion. The selectivity of MIPs also demonstrated higher affinity for target BPA over competitive phenolic compounds than that of non‐imprinted polymers (NIPs).
Arsenic Removal from Natural Water Using Low Cost Granulated Adsorbents: A Review
Authors: Baig Shams Ali , Sheng Tiantian , Hu Yunjun , Xu Jiang , Xu Xinhua 
Published: July 2013

AbstractElevated arsenic concentrations have been detected in drinking water sources worldwide and it threatens to over 200 million people in both developing and developed countries. Adsorption is a conventional process for arsenic removal from contaminated water. Several classes of adsorbing materials have been tested so far. However, far less attention was paid towards granular‐based adsorption and granulation processes. The present work is the first attempt to consider both the granular adsorbent and the granulation process. A particular emphasis was given to cost‐efficient adsorbent for small scale arsenic removal. Some of the features of granular adsorbents are summarized in tables and graphs; address necessary outlines for readers to easily overview the adsorbents' characteristics and design sustainable adsorption system. Earlier, cost of arsenic removals from granular adsorbents were not widely affirmed, but in this review few of them are incorporated for comparisons in future studies. Thus, one gram of arsenic removal from water using novel and iron oxide‐coated sand adsorbents is approximately ranged US$2.3–5.1 and US$3.3–4.2, respectively. Moreover, methods employed for regeneration of exhausted granular adsorbents are discussed. Field scale arsenic remediation measures and the performance evaluations are additionally reported to identify the feasibility of these approaches for scaling up, awareness raising and promotion.
Flow‐induced ATP release in patient‐specific arterial geometries – a comparative study of computational models
Authors: Boileau E. , Bevan R. L. T. , Sazonov I. , Rees M. I. , Nithiarasu P. 
Published: July 2013

SUMMARYThe importance of the endothelium in the local regulation of blood flow is reflected by its influence on vascular tone by means of vasodilatory responses to many physiological stimuli. Regulatory pathways are affected by mass transport and wall shear stress (WSS), via mechanotransduction mechanisms. In the present work, we review the most relevant computational models that have been proposed to date, and introduce a general framework for modelling the responses of the endothelium to alteration in the flow, with a view to understanding the biomechanical processes involved in the pathways to endothelial dysfunction. Simulations are performed on two different patient‐specific stenosed carotid artery geometries to investigate the influence of WSS and mass transport phenomena upon the agonist coupling response at the endothelium. In particular, results presented for two different models of WSS‐dependent adenosine‐5’‐triphosphate (ATP) release reveal that existing paradigms may not account for the conditions encountered in vivo and may therefore not be adequate to model the kinetics of ATP at the endothelium. Copyright © 2013 John Wiley & Sons, Ltd.
An Exploration of People's Experiences of Compassion‐focused Therapy for Trauma, Using Interpretative Phenomenological Analysis
Authors: Lawrence Verity A. , Lee Deborah 
Published: July 2013

Self‐compassion enhances psychological well‐being, and compassion‐focused therapy aims to alleviate psychological distress by fostering its development. The experience of becoming self‐compassionate for people with complex mental health difficulties has not been analysed in the literature, despite clinical observations that this process is difficult. This study explored the process of becoming self‐compassionate for people with posttraumatic stress disorder, using interpretative phenomenological analysis.Semi‐structured interviews were conducted with seven participants. Five superordinate themes emerged from the data including: (1) the battle to give up the inner critic: who am I if I am not self‐critical?; (2) an aversive and alien experience: how it feels to develop self‐compassion; (3) the emotional experience of therapy; (4) self‐compassion as a positive emotional experience; and (5) a more positive outlook in the present and for the future. Self‐criticism formed an important part of the participants' self‐identity, and they experienced an initially aversive emotional response to self‐compassion, describing it as a completely new experience and one to be feared. Despite this, they were able to persist with therapy and subsequently experience positive emotional responses to self‐compassion. They reported the therapeutic relationship as an important factor making this possible. Participants reflected on several reasons for the aversive nature of developing self‐compassion, which are discussed. A process model of the journey from self‐criticism to self‐compassion is proposed. It is suggested that the obstacles frequently experienced when developing self‐compassion can be overcome, instilling hope for both therapists and clients. Copyright © 2013 John Wiley & Sons, Ltd.Key Practitioner MessageThe process of developing compassion for the self can be frightening for people who have a tendency to be self‐critical and have few experiences of compassion from others.Despite this initially aversive response, participants in this study were able to develop self‐compassion and experience its benefits, such as increased hopefulness for the future.Therapists are encouraged to persist with compassion‐focused therapy when met with resistance from clients, since overcoming this can be a key part of the therapeutic process.
Design and Synthesis of a Prototype Scaffold for Five‐Residue α‐Helix Mimetics
Authors: Bayly Andrew R. , White Andrew J. P. , Spivey Alan C. 
Published: July 2013

AbstractThe development of structural mimetics of α‐helices has traditionally focused on representation of the three residues that protrude from one face of the helical surface on three consecutive turns (i.e., i, i+3/i+4, and i+7). Despite the decisive contribution these residues make to the binding interaction with protein partners, peripheral residues can play important roles particularly with regard to imparting selectivity. Here, we describe the design and synthesis of a model azabicyclo[2.2.2]octane aryl amide scaffold designed to compactly present the i, i+1, i+2, i+4, and i+5 residues of an α‐helix.
Antisaccadic Training to Improve Impulsivity in Binge Eating Disorder
Authors: Giel Katrin Elisabeth , Schag Kathrin , Plewnia Christian , Zipfel Stephan 
Published: July 2013

AbstractPatients with binge eating disorder (BED) show generally increased impulsivity and especially increased food‐related impulsivity. Both are closely linked to the core pathology of BED, which relates to regular binge eating episodes with experienced loss of control. The antisaccade task is an established paradigm assessing response inhibition as a pivotal component of impulsivity. It requires participants to execute antisaccades; that is, they are supposed to look in the opposite direction of a stimulus that automatically catches attention by appearing in the peripheral visual field. High rates of prosaccades to the peripheral stimuli are considered indicators of increased impulsivity. Presenting food pictures as peripheral stimuli, this task can be used to investigate food‐related impulsivity. We propose modifications of this task in order to design it as an antisaccadic training in which BED patients practise the suppression of food‐related responses, which should result in enhanced control over their eating behaviour. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
Carbon burial in soil sediments from Holocene agricultural erosion, Central Europe
Authors: Hoffmann Thomas , Schlummer Manuela , Notebaert Bastiaan , Verstraeten Gert , Korup Oliver 
Published: July 2013

AbstractNatural and human‐induced erosion supplies high amounts of soil organic carbon (OC) to terrestrial drainage networks. Yet OC fluxes in rivers were considered in global budgets only recently. Modern estimates of annual carbon burial in inland river sediments of 0.6 Gt C, or 22% of C transferred from terrestrial ecosystems to river channels, consider only lakes and reservoirs and disregard any long‐term carbon burial in hillslope or floodplain sediments. Here we present the first assessment of sediment‐bound OC storage in Central Europe from a synthesis of ~1500 Holocene hillslope and floodplain sedimentary archives. We show that sediment storage increases with drainage‐basin size due to more extensive floodplains in larger river basins. However, hillslopes retain hitherto unrecognized high amounts of eroded soils at the scale of large river basins such that average agricultural erosion rates during the Holocene would have been at least twice as high as reported previously. This anthropogenic hillslope sediment storage exceeds floodplain storage in drainage basins <105 km2, challenging the notion that floodplains are the dominant sedimentary sinks. In terms of carbon burial, OC concentrations in floodplains exceed those on hillslopes, and net OC accumulation rates in floodplains (0.7 ± 0.2 g C m−2a−1) surpass those on hillslopes (0.4 ± 0.1 g C m−2a−1) over the last 7500 years. We conclude that carbon burial in floodplains and on hillslopes in Central Europe exceeds terrestrial carbon storage in lakes and reservoirs by at least 2 orders of magnitude and should thus be considered in continental carbon budgets.
Exploring global nitrogen and phosphorus flows in urban wastes during the twentieth century
Authors: Morée A. L. , Beusen A. H. W. , Bouwman A. F. , Willems W. J. 
Published: July 2013

AbstractThis paper presents a global model‐based country‐scale quantification of urban N and P mass flows from humans, animals, and industries and their waste N and P discharges to surface water and urban waste recycling in agriculture. Agricultural recycling was practiced commonly in early twentieth century Europe, Asia, and North America. During the twentieth century, global urban discharge to surface water increased ~3.5‐fold to 7.7 Tg yr‐1 for N and ~4.5‐fold to 1.0 Tg yr‐1 for P; the major part of this increase occurred between 1950 and 2000. Between 1900 and ~1940, industrial N and P flows dominated global surface water N and P loadings from urban areas; since ~1940, human wastes are the major source of urban nutrient discharge to both surface water and agricultural recycling. During the period 1900–2000, total global recycling of urban nutrients in agriculture increased from 0.4 to 0.6 Tg N yr‐1 and from 0.07 to 0.08 Tg P yr‐1. A large number of factors (the major ones related to food consumption, urban population, sewer connection, and industrial emissions) contribute to the uncertainty of −18% to +42% for N and −21% to +45% for P around the calculated surface water loading estimate for 2000.