bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Tandem Reduction—Oxidation Protocol for the Conversion of 1‐Keto‐1,2,3,4‐tetrahydrocarbazoles to Carbazoles via Tosylhydrazones Through Microwave Assistance: Efficient Synthesis of Glycozoline, Clausenalene, Glycozolicine, and Deoxycarbazomycin B and the Total Synthesis of Murrayafoline A.
Authors: Chakraborty Suchandra , Chattopadhyay Gautam , Saha Chandan 
Published: June 2013

AbstractCarbazoles (III), including the title natural derivatives, are synthesized by the title protocol on magnesium sulfate as solid support.
ChemInform Abstract: Gold‐Catalyzed Michael Addition/Intramolecular Annulation Cascade: An Effective Pathway for the Chemoselective‐ and Regioselective Synthesis of Tetracyclic Indole Derivatives in Water.
Authors: Xu Shengtao , Zhou Yu , Xu Jinyi , Jiang Hualiang , Liu Hong 
Published: June 2013

AbstractOptimum reaction conditions are examined for the synthesis of 28 title compounds of type (III) which are of potential biological interest.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.
Authors: Lim Andrew D. , Codelli Julian A. , Reisman Sarah E. 
Published: June 2013

AbstractA catalytic enantioselective double 1,3‐dipolar cycloaddition providing access to highly substituted pyrrolizidines, e.g. (IV), (VI), and (VIII) is described.
ChemInform Abstract: Regioselective Methylation of Indazoles Using Methyl 2,2,2‐Trichloromethylacetimidate.
Authors: Baddam Sudhakar Reddy , Kumar N. Uday , Reddy A. Panasa , Bandichhor Radeshwar 
Published: June 2013

AbstractAn efficient protocol is developed for the selective 2‐methylation of indazoles, which is of interest in drug synthesis.
ChemInform Abstract: Copper‐Catalyzed C—H Alkoxylation of Azoles.
Authors: Takemura Noriaki , Kuninobu Yoichiro , Kanai Motomu 
Published: June 2013

AbstractThe new copper‐catalyzed intramolecular and intermolecular alkoxylation of azoles proceeds under base‐free conditions even on gram scale.
ChemInform Abstract: Copper‐Catalyzed Click Synthesis of Functionalized 1,2,3‐Triazoles with 3,4‐Dihydropyrimidinone or Amide Group via a One‐Pot Four‐Component Reaction.
Authors: Quan Zheng‐Jun , Xu Qiong , Zhang Zhang , Da Yu‐Xia , Wang Xi‐Cun 
Published: June 2013

AbstractThis one‐pot, two‐step protocol gives rise to N‐functionalized triazoles by a Cu(I)‐catalyzed multicomponent reaction between dihydropyrimidinones, paraformaldehyde, sodium azide, and alkynes.
ChemInform Abstract: Synthesis, Characterization and Preliminary Anticonvulsant Evaluation of Some 4‐Alkyl‐1,2,4‐triazoles.
Authors: Plech Tomasz , Luszczki Jarogniew J. , Wujec Monika , Flieger Jolanta , Pizon Magdalena 
Published: June 2013

AbstractMost of the new triazole derivatives (VI) possess significant anticonvulsant activities.
ChemInform Abstract: MW Assisted Synthesis of Some Pyrazoles Containing Benzotriazole Moiety: An Environmentally Benign Approach.
Authors: Tiwari Urvashi , Ameta Chetna , Rawal Manish K. , Ameta Rakshit , Punjabi Pinki B. 
Published: June 2013

AbstractThe title compounds (IV) (14 examples) are obtained by microwave assisted cyclocondensation of substituted chalcones (III) with hydrazide of benzotriazole (II).
ChemInform Abstract: A Hetero Diels—Alder Approach to the Synthesis of Chromans (3,4‐Dihydrobenzopyrans) Using Oxonium Ion Chemistry: The Oxa‐Povarov Reaction.
Authors: Taylor Rivka R. R. , Batey Robert A. 
Published: June 2013

AbstractThe reaction represents the formal inverse electron demand [4 + 2] cycloaddition reaction of in situ‐generated cationic aryl 2‐oxadiene oxocarbenium ions with alkenes.
ChemInform Abstract: Construction of the Flavones and Aurones Through Regioselective Carbonylative Annulation of 2‐Bromophenols and Terminal Alkynes.
Authors: Liu Jianming , Liu Muwen , Yue Yuanyuan , Zhang Ningfei , Zhang Yuanli , Zhuo Kelei 
Published: June 2013

AbstractA slight modification in the amine solvent allows the selective preparation of the target skeletons.
ChemInform Abstract: Efficient Synthesis of N‐(9‐Xanthyl)‐4‐toluenesulfonamides Enabled by an Addition—Cyclization Cascade of Arynes.
Authors: Lu Shan‐Shan , Lu Chong‐Dao 
Published: June 2013

AbstractAn asymmetric version using imine (VII) gives the product (VIII) with only poor diastereoselectivity.
ChemInform Abstract: Gold‐Catalyzed Intramolecular Hydroamination of o‐Alkynylbenzyl Carbamates: A Route to Chiral Fluorinated Isoindoline and Isoquinoline Derivatives.
Authors: Fustero Santos , Ibanez Ignacio , Barrio Pablo , Maestro Miguel A. , Catalan Silvia 
Published: June 2013

AbstractTitle compounds are prepared in enantiomerically pure form by the diastereoselective addition of fluorinated nucleophiles to N‐(tert‐butanesulfinyl)imines (I) followed by a sequence of Sonogashira cross‐coupling/gold(I)‐catalyzed cycloisomerization of the corresponding carbamate.
ChemInform Abstract: Synthesis and Evaluation of Antibacterial Activity of 7‐Alkyloxy‐4,5‐dihydro‐imidazo[1,2‐a]quinoline Derivatives.
Authors: Sun Xian‐Yu , Wu Rui , Wen Xiang , Guo Li , Zhou Chang‐Ping , Li Jian , Quan Zhe‐Shan , Bao Jun 
Published: June 2013

AbstractMost of the new compounds (III) (20 examples) exhibit potential antibacterial activities.
ChemInform Abstract: Three Novel Sequential Reactions for the Facile Synthesis of a Library of Bisheterocycles Possessing the 3‐Aminoimidazo[1,2‐a]pyridine Core Catalyzed by Bismuth(III) Chloride.
Authors: Shahrisa Aziz , Esmati Somayeh 
Published: June 2013

AbstractThe procedures allow the access to the biologically important ring system: BiCl3‐catalyzed three‐component coupling of (het)aromatic aldehydes, 2‐aminopyridines, and isocyanides renders possible the synthesis of 3‐aminoimidazopyridine derivatives.
ChemInform Abstract: Advances in Drug Design and Discovery. Part 24. Discovery of Coumarin—Monastrol Hybrid as Potential Antibreast Tumor‐Specific Agent.
Authors: Sashidhara Koneni V. , Avula Srinivasa Rao , Sharma Komal , Palnati Gopala Reddy , Bathula Surendar Reddy 
Published: June 2013

AbstractA novel class of coumarin‐monastrol hybrids (VI) (7 examples) is synthesized via a Biginelli reaction.
ChemInform Abstract: Mannich Reaction in the Synthesis of N,S‐Containing Heterocycles. Part 15. Multicomponent Cascade Synthesis of 3,4,6a,7,8,9,10,10a‐Octahydro‐2H,6H‐pyrimido[4′,5′:4,5]pyrido[2,1‐b] [1,3,5]thia(selena)diazine Derivatives.
Authors: Frolov K. A. , Dotsenko V. V. , Krivokolysko S. G. 
Published: June 2013

Abstract4 Title compounds of type (VI) are prepared.
ChemInform Abstract: Design, Synthesis and in vitro anti‐Proliferative Activity of 4,6‐Quinazolinediamines as Potent EGFR‐TK Inhibitors.
Authors: Mowafy Samar , Farag Nahla A. , Abouzid Khaled A. M. 
Published: June 2013

AbstractMost of the synthesized compounds exhibit potent EGFR inhibitory activity.
ChemInform Abstract: Synthesis and Antibacterial Evaluation of Bromo Phenyl Substituted Carbazoles.
Authors: Indumathi T. , Brant T. , Zeller M. , Prasad K. J. Rajendra 
Published: June 2013

AbstractA variety of heteroannulated carbazole derivatives (IV), (VII) and (IX) are synthesized and screened for their in vitro antibacterial activities against S.
ChemInform Abstract: Solvent Free Microwave Assisted Synthesis and Evaluation of Potent Antimicrobial Activity of 1,11H‐Pyrimido[4,5‐a]carbazol‐2‐ones, 1,11H‐Pyrimido [4,5‐a]Carbazol‐2‐thiones and Pyrazolo[3,4‐a]carbazoles.
Authors: Velmurugan R. , Vijayasankar A. V. , Sekar M. 
Published: June 2013

AbstractSome of the synthesized compounds exhibit significant antibacterial and antifungal activity.
ChemInform Abstract: Synthesis of 4‐Hydrazinopyrazolo[3,4‐d]pyrimidines and Their Reactions with Carbonyl Compounds.
Authors: Edrees Mastoura M. 
Published: June 2013

AbstractA new 4‐hydrazinopyrazolo[3,4‐d]pyrimidine (II) is synthesized by heating 4,6‐dithioxo‐1H‐pyrazolopyrimidine (I) with hydrazine hydrate.
ChemInform Abstract: Cu(II)‐Catalyzed Synthesis of Quinoxalines from o‐Phenylenediamines and Nitroolefins.
Authors: Chen Yongxin , Li Kangning , Zhao Mingming , Li Yuanjiao , Chen Baohua 
Published: June 2013

AbstractOptimized conditions which do not need any additional base allow the preparation of various title compounds with a broad substitution pattern.
ChemInform Abstract: Silver‐Catalyzed Incorporation of Carbon Dioxide into o‐Alkynylaniline Derivatives.
Authors: Ishida Tomonobu , Kikuchi Satoshi , Tsubo Tatsuyuki , Yamada Tohru 
Published: June 2013

AbstractBenzoxazine‐2‐one derivatives are important heterocyclic structures due to their various pharmaceutical activities.
ChemInform Abstract: An Efficient Two‐Step Synthesis of Novel 2‐Amino‐Substituted Pyrazolo[1,5‐a][1,3,5]triazines.
Authors: Insuasty Henry , Insuasty Braulio , Castro Edison , Quiroga Jairo , Abonia Rodrigo 
Published: June 2013

AbstractSubstrates (I), prepared according to a recently reported procedure, undergo amination/cyclization upon treatment with amines in the presence of HgCl2/NEt3.
ChemInform Abstract: Domino [3 + 2 + 1] Heterocyclization of Isothiocyanates with Aryl Amidines Leading to Polysubstituted 1,3,5‐Triazine Derivatives.
Authors: Li Na , Tu Man‐Su , Jiang Bo , Wang Xiang , Tu Shu‐Jiang 
Published: June 2013

AbstractA convenient one‐pot procedure renders possible the preparation of triazine derivatives (24 examples) in a short time.
ChemInform Abstract: Diastereoselective Access to Polyoxygenated Polycyclic Spirolactones Through a Rhodium‐Catalyzed [3 + 2] Cycloaddition Reaction: Experimental and Theoretical Studies.
Authors: Rodier Fabien , Rajzmann Michel , Parrain Jean‐Luc , Chouraqui Gaelle , Commeiras Laurent 
Published: June 2013

AbstractDepending on the length of the chain between the diazo moiety and the exocyclic double bond either the spiro compounds (II and IV) or the pyran derivatives (VI) are formed.
ChemInform Abstract: Synthesis of Tetrazoloquinoline‐Based Mono‐ and Bisphosphonate Esters as Potent Antiinflammatory Agents.
Authors: Abdou Wafaa M. , Khidre Rizk E. , Shaddy Abeer A. 
Published: June 2013

AbstractThree different types of new phosphono‐substituted tetrazolo quinolines are synthesized by reacting 2‐azidoquinoline‐3‐carboxaldehydes (I) with phosphites, phosphines, and Horner—Emmons reagent.
ChemInform Abstract: Water Enhanced Synthesis of gem‐Bisphosphonates via Rh(I) Mediated 1,4‐Conjugate Addition of Aryl Boronic Acids to Vinylidenebisphosphonate Esters.
Authors: Bianchini Giulio , Scarso Alessandro , Chiminazzo Andrea , Sperni Laura , Strukul Giorgio 
Published: June 2013

AbstractThe employment of water as the solvent is crucial to substantially improve the yields with a wide range of boronic acids (II) and esters (IV) bearing various functionalities.
ChemInform Abstract: One‐Pot Synthesis of Organophosphate Monoesters from Alcohols.
Authors: Lira Lucas M. , Vasilev Dimitri , Pilli Ronaldo A. , Wessjohann Ludger A. 
Published: June 2013

AbstractA reactive phosphorylated trichloroacetimidate, prepared in situ, is treated with alcohols to form organophosphate monoesters as ammonium salts which are used in biological processes.
ChemInform Abstract: Simple Cleavage of Diorganyl Diselenides with NaBH4/PEG‐400 and Direct Michael Addition to Electron‐Deficient Alkenes.
Authors: Perin Gelson , Borges Elton L. , Rosa Paloma C. , Carvalho Patrick N. , Lenardao Eder J. 
Published: June 2013

AbstractA new protocol renders possible in situ generation of nucleophilic selenium species which allow the preparation of Se‐functionalized Michael adducts.
ChemInform Abstract: Bis‐Vinyl Selenides Obtained via Iron(III) Catalyzed Addition of PhSeSePh to Alkynes: Synthesis and Antinociceptive Activity.
Authors: Sartori Glaubia , Neto Jose S. S. , Pesarico Ana Paula , Back Davi F. , Nogueira Cristina W. , Zeni Gilson 
Published: June 2013

AbstractThe pharmacological results demonstrate that some derivatives, e.g. (IIIf), elicite antinociceptive effects in the mouse formalin test.
ChemInform Abstract: Organotellurium Chemistry: Remarkably Facile Preparation of Benzo‐1,3‐tellurazoles.
Authors: McMullen Nathan C. , Fronczek Frank R. , Junk Thomas 
Published: June 2013

AbstractA facile two‐step sequence for the synthesis of the title compounds is presented from readily available 2‐haloanilines (I).
ChemInform Abstract: Synthesis and Antitumor Activity of New Substituted Mercapto‐1,2,4‐triazine Derivatives, Their Thioglycosides, and Acyclic Thioglycoside Analogues.
Authors: Nassar Ibrahim F. 
Published: June 2013

AbstractTitle compounds are synthesized starting from triazine derivative (I) and evaluated for their antitumor and cytotoxic activities.
ChemInform Abstract: Enantioselective Total Synthesis of Virosaine A and Bubbialidine.
Authors: Miyatake‐Ondozabal Hideki , Bannwart Linda M. , Gademann Karl 
Published: June 2013

AbstractAn intramolecular 1,3‐dipolar cycloaddition is applied to construct the complex ring system of virosaine A (I).
ChemInform Abstract: Anisotropy of Spin Relaxation and Transverse Transport in Metals
Authors: Mokrousov Yuriy , Zhang Hongbin , Freimuth Frank , Zimmermann Bernd , Long Nguyen H. , Weischenberg Juergen , Souza Ivo , Mavropoulos Phivos , Bluegel Stefan 
Published: June 2013

AbstractReview: theoretical considerations; 96 refs.
ChemInform Abstract: Glycal‐Derived δ‐Hydroxy α,β‐Unsaturated Aldehydes (Perlin Aldehydes): Versatile Building Blocks in Organic Synthesis
Authors: Reddy L. Vijaya Raghava , Kumar Vikas , Sagar Ram , Shaw Arun K. 
Published: June 2013

AbstractReview: 97 refs.
Treatment of early‐stage prostate cancer among rural and urban patients
Authors: Baldwin Laura‐Mae , Andrilla C. Holly A. , Porter Michael P. , Rosenblatt Roger A. , Patel Shilpen , Doescher Mark P. 
Published: June 2013

BACKGROUNDGeographic barriers and limited availability of cancer specialists may influence early prostate cancer treatment options for rural men. This study compares receipt of different early prostate cancer treatments between rural and urban patients.METHODSUsing 2004‐2006 SEER Limited‐Use Data, 51,982 early prostate cancer patients were identified (T1c, T2a, T2b, T2c, T2NOS; no metastases) who were most likely to benefit from definitive treatment (< 75 years old, Gleason score < 8, PSA ≤ 20). Definitive treatment included radical prostatectomy, daily external beam radiation for 5 to 8 weeks, brachytherapy, or combination external beam radiation/brachytherapy. Adjusted definitive treatment rates were calculated by rural–urban residence overall, and for different sociodemographic and cancer characteristics, and different states based on logistic regression analyses, using general estimating equation methods to account for clustering by county.RESULTSAdjusted definitive treatment rates were lower for rural (83.7%) than urban (87.1%) patients with early‐stage prostate cancer (P ≤ .01). Rural men were more likely than urban men to receive nondefinitive surgical treatment and no initial treatment. The lowest definitive treatment rates were among rural subgroups: 70 to 74 years (73.9%), African Americans (75.6%), American Indians/Alaska Natives (77.8%), single/separated/divorced (76.8%), living in New Mexico (69.3%), and living in counties with persistent poverty (79.6%).CONCLUSIONSBetween 2004 and 2006, this adjusted analysis found that men who were living in rural areas were less likely to receive definitive treatment for their early‐stage prostate cancer than those living in urban areas. Certain rural patient groups with prostate cancer need particular attention to ensure their access to appropriate treatment. Rural providerss, rural health care systems, and cancer advocacy and support organizations should ensure resources are in place so that the most vulnerable rural groups (men between 60 and 74 years of age; African American men; men who are single, separated, or divorced; and men living in rural New Mexico) can make informed prostate cancer treatment choices based on their preferences. Cancer 2013;119:3067—3075. © 2013 American Cancer Society.
Repetitively dosed docetaxel and 153samarium‐EDTMP as an antitumor strategy for metastatic castration‐resistant prostate cancer
Authors: Autio Karen A. , Pandit‐Taskar Neeta , Carrasquillo Jorge A. , Stephenson Ryan D. , Slovin Susan F. , Rathkopf Dana E. , Hong Christina , Heller Glenn , Scher Howard I. , Larson Steven M. , Morris Michael J. 
Published: June 2013

BACKGROUNDβ‐emitting bone‐seeking radiopharmaceuticals have historically been administered for pain palliation whereas docetaxel prolongs life in patients with metastatic castration‐resistant prostate cancer (mCRPC). In combination, these agents simultaneously target the bone stroma and cancer cell to optimize antitumor effects. The toxicity and efficacy when each agent is combined at full, recommended doses, in a repetitive fashion is not well established.METHODSPatients with progressive mCRPC and ≥3 bone lesions received 153Sm‐EDTMP (samarium‐153 ethylene diamine tetramethylene phosphonate) at a dose of 1.0 mCi/kg every 9 weeks and docetaxel at a dose of 75 mg/m2 every 3 weeks. In the absence of unacceptable toxicity, patients were allowed to continue additional cycles, defined by 9 weeks of treatment, until intolerance or biochemical/radiographic disease progression.RESULTSOf the 30 patients treated, approximately 50% were considered to be taxane‐naive, 36.7% were taxane‐refractory, and 13.3% had previously been exposed to taxanes but were not considered refractory. Patients received on average 2.5 cycles of treatment (6.5 doses of docetaxel and 2.5 doses of 153Sm‐EDTMP). Twelve patients (40%) demonstrated a decline in their prostate‐specific antigen level of ≥50%. The median progression‐free survival (biochemical or radiographic) was 7.0 months and the overall survival was 14.3 months. Nine patients (30%) did not recover platelet counts >100 K/mm3 after a median of 3 cycles to allow for additional treatment, with 4 patients experiencing prolonged thrombocytopenia. The most common reasons for trial discontinuation were progressive disease and hematologic toxicity.CONCLUSIONSThe results of the current study indicate that 153Sm‐EDTMP can be safely combined with docetaxel at full doses on an ongoing basis in patients with mCRPC. Although thrombocytopenia limited therapy for some patients, preliminary efficacy supports the strategy of combining a radiopharmaceutical with chemotherapy, which is an appealing strategy given the anticipated availability of α emitters that can prolong survival. Cancer 2013;119:3186–3194. © 2013 American Cancer Society.
Kaposi sarcoma herpesvirus/human herpesvirus‐8–negative effusion‐based lymphoma: Report of 3 cases and review of the literature
Authors: Xiao Jingnan , Selvaggi Suzanne M. , Leith Catherine P. , Fitzgerald Sean A , Stewart Jimmie 
Published: June 2013

BACKGROUNDPrimary effusion lymphoma (PEL) is a rare subtype of large B‐cell lymphoma that arises in body cavities without detectable tumor masses. PEL is universally associated with Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus‐8 (HHV8). Despite overlapping features, KSHV/HHV8‐negative effusion‐based lymphoma is a distinct entity from PEL. To date, 52 cases have been reported. The authors report 3 additional cases received in their laboratory from 2007 to 2012.METHODSClinical data, cytomorphologic features, and immunophenotypic features of the 3 cases were described and compared with those reported in the literature.RESULTSThe cells in HHV8‐negative effusion lymphoma commonly revealed large cell, immunoblastic morphology and B‐cell immunophenotype. The 3 cases demonstrated cytomorphologic and immunophenotypic variability. Cytomorphologically, 1 case contained large, highly atypical cells with a moderate amount of cytoplasm, round nucleus, coarsely granular chromatin, and a single macronucleolus. The other 2 cases had medium to large atypical cells with high nuclear‐to‐cytoplasmic ratios, slightly irregular to cleaved nuclei, and multiple conspicuous nucleoli. One case had a null phenotype with aberrant cytokeratin expression. B‐cell phenotype was established by clonal immunoglobulin heavy‐chain rearrangement using polymerase chain reaction, whereas the other 2 cases demonstrated a B‐cell phenotype by flow cytometry and immunohistochemical staining. All 3 cases were negative for both HHV8 and Epstein‐Barr virus.CONCLUSIONSHHV8‐negative effusion lymphoma exhibits clinical, cytomorphologic, and immunophenotypic variability. Cases with a null‐phenotype can be particularly challenging. When effusion lymphoma is suspected, ancillary tests are helpful. Moreover, HHV8 detection is critical in differentiating PEL and HHV8‐negative effusion lymphoma, because they have overlapping features yet different prognoses. Cancer (Cancer Cytopathol) 2013;121:661–9. © 2013 American Cancer Society.
Theoretical Photodynamic Study of the Photoprotolytic Cycle of Firefly Oxyluciferin
Authors: Pinto da Silva Luís , Simkovitch Ron , Huppert Dan , Esteves da Silva Joaquim C. G. 
Published: June 2013

AbstractFirefly oxyluciferin presents a pH‐sensitive fluorescence in aqueous solutions. Its fluorescence spectra are composed of two green peaks at different pH values, despite the enolate anion being the only emitter. A computational approach was used to further elucidate the photoprotolytic cycle of oxyluciferin and investigate its pH sensitivity. It was found that oxyluciferin forms π–π stacking complexes both in the ground and excited states, at basic and acidic/neutral pH. However, at different pH values, these complexes adopt a different conformation, which explains the lower energy of the emission at acidic/neutral pH, in comparison with the emission at basic pH.
The developmental origins of laterality: Fetal handedness
Authors: Hepper Peter G. 
Published: June 2013

ABSTRACTThis paper reviews the evidence for lateralized motor behavior in the fetus around a number of key questions: does the fetus exhibit signs of laterality? when does lateralized motor behavior begin? is the lateralized preference consistently displayed? does prenatal handedness relate to postnatal handedness? and, does prenatal handedness relate to brain functioning? The evidence indicates that the fetus exhibits lateralized behavior from 10 weeks gestation, as soon as it independently moves its arms, and this is the precursor of lateralized motor behavior observed post‐natally. Data is presented suggesting that the strength of laterality decreases with advancing gestation and this correlates with more efficient information processing as assessed by habituation. However extreme caution is warranted in attempting to link asymmetric motor behavior and brain function prenatally. The paper concludes that the initial developmental emergence of lateralized behavior is under genetic control and is a fundamental feature of prenatal human development. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 55: 588–595, 2013.
Age‐dependent time courses of recovery for motor functions following acute toluene intoxication in rats
Authors: Samuel‐Herter Susan R. , Slaght Shelby L. , McKay Bruce E. 
Published: June 2013

ABSTRACTToluene is a psychoactive chemical found in many household products including adhesives and thinners. Inhalation of these vapors can cause euphoria and impairments in motor control and neurological functioning. Misuse and abuse of toluene is most common in children, which may in part be due to an age‐dependent neurobehavioral sensitivity to toluene. Here we assessed the effects of acute binge‐like toluene inhalations (15 or 30 min; ∼5,000 ppm) on tasks that examine locomotion, exploration, balance, gait, and neurological functioning for adolescent (1 month), young adult (2–3 months), adult (5–6 months), and older adult (10–12 months) rats. Both motor and neurological functions were impaired following acute toluene inhalation at all ages. However, only the duration to recover from deficits in motor functions differed among age groups, with adolescent and young adult rats requiring notably longer recovery times than older rats. Our results are suggestive of an age‐dependent vulnerability to the intoxicating effects of toluene. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 657–673, 2014.