bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Recursive Detection Methods for Turning Points in Financial Time Series
Authors: Grillenzoni Carlo 
Published: December 2012

SummaryTimely identification of turning points in economic time series is important for planning control actions and achieving profitability. This paper compares sequential methods for detecting peaks and troughs in stock values and deciding the time to trade. Three semi‐parametric methods are considered: double exponential smoothing, time‐varying parameters and prediction error statistics. These methods are widely used in monitoring, forecasting and control, and their common features are recursive computation and exponential weighting of observations. The novelty of this paper is the selection of smoothing and alarm coefficients for maximisation of the gain (the difference in level between subsequent peaks and troughs) of sample data. The methods are compared on applications to leading financial series and with simulation experiments.
Generalised Variance Function Estimation for Binary Variables in Large‐Scale Sample Surveys
Authors: Cao Ricardo , Vilar José A. , Vilar Juan M. 
Published: December 2012

SummaryGeneralised variance function (GVF) models are data analysis techniques often used in large‐scale sample surveys to approximate the design variance of point estimators for population means and proportions. Some potential advantages of the GVF approach include operational simplicity, more stable sampling errors estimates and providing a convenient method of summarising results when a high number of survey variables is considered. In this paper, several parametric and nonparametric methods for GVF estimation with binary variables are proposed and compared. The behavior of these estimators is analysed under heteroscedasticity and in the presence of outliers and influential observations. An empirical study based on the annual survey of living conditions in Galicia (a region in the northwest of Spain) illustrates the behaviour of the proposed estimators.
Estimating a Single Shelf‐Life for Multiple Batches
Authors: Kiermeier Andreas , Verbyla Arūnas P. , Jarrett Richard G. 
Published: December 2012

SummaryPharmaceutical companies and manufacturers of food products are legally required to label the product's shelf‐life on the packaging. For pharmaceutical products the requirements for how to determine the shelf‐life are highly regulated. However, the regulatory documents do not specifically define the shelf‐life. Instead, the definition is implied through the estimation procedure. In this paper, the focus is on the situation where multiple batches are used to determine a label shelf‐life that is applicable to all future batches. Consequently, the short‐comings of existing estimation approaches are discussed. These are then addressed by proposing a new definition of shelf‐life and label shelf‐life, where greater emphasis is placed on within and between batch variability. Furthermore, an estimation approach is developed and the properties of this approach are illustrated using a simulation study. Finally, the approach is applied to real data.
An interview with Robert Lawler
Authors: Lawler Robert W. , Rushby Nick 
Published: December 2012

AbstractRobert Lawler is one of the key figures in the development of thinkable models and educational games. In this interview, dedicated to Seymour Papert, Marvin Minsky and Oliver Selfridge, he comments on his research notes and provides fascinating insights into the early days of artificial intelligence applications in education.
Two Rare Variants Explain Association with Acute Myocardial Infarction in an Extended Genomic Region Including the Apolipoprotein(A) Gene
Authors: Koch Werner , Mueller Jakob C. , Schrempf Matthias , Wolferstetter Hannah , Kirchhofer Johannes , Schömig Albert , Kastrati Adnan 
Published: December 2012

SummaryRelatively low numbers of kringle 4 type 2 repeats in apolipoprotein(a) and specific haplotypes of the SLC22A3‐LPAL2‐LPA region on chromosome 6 are associated with an increased risk of coronary disease. We examined the possibility that rs3798220 and rs10455872, short variations located in LPA [the apolipoprotein(a) gene], and related to the number of kringle 4 type 2 repeats, may serve as markers for the association between haplotypes and acute myocardial infarction. Genotypes were determined with TaqMan assays in a sample of 2136 cases and 1211 controls. The minor alleles of rs3798220 and rs10455872 were associated with increased risks (rs3798220‐C: adjusted OR 2.14, 95% CI, 1.37–3.33, P = 0.00080; rs10455872‐G: adjusted OR 1.74, 95% CI 1.36–2.24, P < 0.00001). After adjustments were made for potential confounders, none of nine polymorphisms included in a haplotype analysis were singly related to disease. Two risk haplotypes were identified; one (CCTTGTGTG; OR 1.25, 95% CI 1.08–1.45, P = 0.0022) was correlated with rs3798220‐C and the other (CCCTGGATC; OR 1.65, 95% CI 1.14–2.38, P = 0.0074) with rs10455872‐G. Thus, the findings allowed for a more precise definition of risk‐associated markers: specific nucleotides in LPA instead of standard haplotypes defined by noneffective variants from the extensive SLC22A3‐LPAL2‐LPA region.
Sonographic and electrodiagnostic features of hereditary neuropathy with liability to pressure palsies
Authors: Ginanneschi Federica , Filippou Georgios , Giannini Fabio , Carluccio Maria A. , Adinolfi Antonella , Frediani Bruno , Dotti Maria T. , Rossi Alessandro 
Published: December 2012

AbstractIn hereditary neuropathy with liability to pressure palsies (HNPP), the increase in distal motor latencies (DMLs) is often out of proportion to the slowing of conduction velocities, but the pathophysiological mechanism is still unclear. We used a combined electrophysiological and ultrasonographic (US) approach to provide insight into this issue. Twelve HNPP subjects underwent extensive electrophysiological studies and US measurements of the cross‐sectional area (CSA) of several peripheral nerves. US nerve enlargement was only observed in the carpal tunnel, Guyon's canal, the elbow and the fibular head. We did not observe US abnormalities at sites where nerve entrapment is uncommon. An increase in DMLs was observed regardless of US nerve enlargement. The increased nerve CSA only in common sites of entrapment likely reflected the well‐documented nerve vulnerability to mechanical stress in HNPP. No morphometric changes were seen in the distal nerve segments where compression/entrapment is unlikely, despite the fact that the DMLs were increased. These data suggest that factors other than mechanical stress are responsible for the distal slowing of action potential propagation. We speculate that a mixture of mechanical insults and an axon‐initiated process in the distal nerves underlies the distal slowing and/or conduction failure in HNPP.
Unusual features of central nervous system involvement in CMTX associated with a novel mutation of GJB1 gene
Authors: Stancanelli Claudia , Taioli Federica , Testi Silvia , Fabrizi Gian Maria , Arena Maria Grazia , Granata Francesca , Russo Massimo , Gentile Luca , Vita Giuseppe , Mazzeo Anna 
Published: December 2012

AbstractIn this study, we report a novel connexin 32 (CX32) mutation associated with cognitive impairment and a differential degree of peripheral nerve involvement. We present clinical, electrophysiological, and neuroimaging data on a family with X‐linked Charcot‐Marie‐Tooth disease caused by a 41A>G mutation of the gap junction protein beta 1 (GJB1) gene. The proband and her sister presented with a severe neuropathy with subclinical cognitive impairment; the proband's brother showed severe cognitive impairment and a mild neuropathy. This family report confirms that Charcot‐Marie‐Tooth type X is a clinically heterogeneous group, with great variability of phenotypes, possible severe involvement in females and clinical signs of cognitive impairment. Thus, this novel mutation should be added to the group of CX32 mutations with a central nervous system phenotype.
Hereditary neuropathy with liability to pressure palsies. Diagnosis in the first family (1947) confirmed
Authors: Koehler Peter J. , Baas Frank 
Published: December 2012

AbstractIn 1947, the Dutch neurologist De Jong published the first family with, what later would be called, hereditary neuropathy with liability to pressure palsies (HNPP). We recently found a new case from this family and were able to confirm the diagnosis by DNA analysis.
Two novel mutations of GARS in Korean families with distal hereditary motor neuropathy type V
Authors: Lee Hye Jin , Park Jin , Nakhro Khriezanou , Park Jin Mo , Hur Yoon‐Mi , Choi Byung‐Ok , Chung Ki Wha 
Published: December 2012

AbstractGlycyl‐tRNA synthetase (GARS), which encodes the enzyme responsible for charging tRNA(Gly) with glycine in both the cytoplasm and mitochondria, is implicated to Charcot‐Marie‐Tooth disease 2D (CMT2D) and distal hereditary motor neuropathy type V (dHMN‐V). We performed whole exome sequencing (WES) to identify the genetic defects in the two dHMN families. WES revealed several decades of non‐synonymous variants in the CMT and aminoacyl‐tRNA synthetase genes. The subsequent capillary sequencing for family members and controls revealed two novel causative mutations, c.598G>A (D200N) and c.794C>T (S265F), in the GARS gene in each dHMN family. Both mutations were cosegregated with affected individuals in each family, and were not found in the 200 controls. The mutation sites were well conserved between the different species and in silico analysis predicted that both mutations may affect protein function. Therefore, we believe that these two novel GARS mutations are the underlying causes of the dHMN phenotype.
Evaluation of Fracture Resistance in Aqueous Environment of Four Restorative Systems for Posterior Applications. Part 1
Authors: Dhima Matilda , Assad Daniel A. , Volz John E. , An Kai‐Nan , Berglund Lawrence J. , Carr Alan B. , Salinas Thomas J. 
Published: December 2012

AbstractPurposeThe goals of this study were to: (1) establish a range of the performance of four restorative systems for posterior single‐tooth crowns under single load to fracture submerged in an aqueous environment, (2) identify restorative system(s) of interest to be examined in the second study phase under sliding contact step‐stress fatigue as full‐contour anatomically appropriate single posterior tooth restoration(s), (3) establish a range for loading/testing for phase 2.Materials and MethodsForty specimens (n = 10/group) of 2 mm uniform thickness were tested. Group 1: monolithic lithium disilicate IPS e.max Press; group 2: IPS e.max ZirPress, 0.8 mm zirconia core with 1.2 mm pressed veneering porcelain; group 3: IPS e.max ZirPress, 0.4 mm zirconia core with 1.6 mm pressed veneering porcelain; group 4: IPS InLine PoM. Specimens were bonded to a block of polycast acrylic resin on a 30° sloped surface with resin cement. Specimens were axially single loaded to failure while submerged under water.ResultsThere was a statistically significant difference (p < 0.001) in failure load among the four restorative systems. Lithium disilicate showed a mean failure load similar to mean maximum posterior bite forces (743.1 ± 114.3 N). IPS e.max Zirpress with a 0.4 mm zirconia core exhibited the lowest mean failure load (371.4 ± 123.0 N).ConclusionFracture resistance of monolithic lithium disilicate in an aqueous environment is promising and requires second phase testing to evaluate the potential of various thicknesses appropriate for posterior single tooth applications. Doubling the IPS e.max Zirpress zirconia core from 0.4 mm to 0.8 mm increased the fracture resistance of this restorative system threefold.
FEA Evaluation of the Resistance Form of a Premolar Crown
Authors: Bowley John F. , Ichim Ionut P. , Kieser Jules A. , Swain Michael V. 
Published: December 2012

AbstractPurposeThe purpose of this study was to evaluate the influence of buccal and lingual wall convergence angles on the ability of the preparation to resist rotational displacement.Materials and MethodsAn intact premolar digitized by micro‐CT yielded a 3D reproduction of a human tooth. Simulated crown preparations with known buccolingual axial wall convergence angles (4°, 8°, 12°, 16°, 20°, 24°, 28° 32°), sloped‐shoulder marginal area, and occlusal reduction were created and restored with a ceramic crown. The tooth restoration was loaded with a 200 N force at 45° to the incline of the buccal cusp. The responses of the restored tooth with luting agents were analyzed using the 3D finite element method.ResultsThis study demonstrated that a convergence angle of the preparation above 12° produced a decrease of the resistance of the crown to rotational effects. The study also showed that the use of luting agents that provide bonding between the restoration and dentine improved the rotational resistance of the crown on preparations with large convergence angles.ConclusionsUse of buccolingual convergence angles greater than 12° reduced the resistance form of the preparation. Luting agents capable of delivering strong bonding between the crown and the preparation improved the resistance in highly tapered preparations.
Economics, Darwinism, and the Case of Disciplinary Imports
Authors: Cojanu Valentin 
Published: December 2012

AbstractThe problem of causality in economics is still contended by various epistemological alternatives. The article builds on the received view of Darwinism in economics and examines the way in which economics and biology find common ground in concepts and assumptions that reflect causal commonalities of the natural and the social world. We claim that the role the contingent pattern plays in understanding socioeconomic change provides reasons to concede corrections to a rule‐based causal mechanism. The article concludes on the merits of advancing the ontological equivalent of interdisciplinary studies as one possible standard in reference to which to judge the epistemic adequacy of any import.
Important Determinants of Child Labor: A Case Study for Lahore
Authors: Siddiqi Ahmed F. 
Published: December 2012

AbstractChild labor is a persistent problem both for developing and developed countries. Academic literature holds a household responsible for this phenomenon where poverty, literacy level, and the de facto demography are considered important. A factor model is attempted in this study to investigate dynamics of child labor in a society in terms of these household characteristics. The model reveals that household‐poverty‐driven factors are the most serious while the household demography is the second most serious factor in the dynamics of child labor in Lahore. Shockingly, household literacy does not have any role to play, at least not in Lahore. The results will help policymakers to work in the domain of poverty to mitigate child labor, and also urge them to align societal factors, which shape household demography.
Task‐Related Variation in Computer‐Assisted Language Learning
Authors: Heift Trude , Rimrott Anne 
Published: December 2012

AbstractThis study investigates task‐related variation in learner performance in a computer‐assisted language learning (CALL) environment. For our study, we collected data from 15 beginner and then intermediate second language (L2) learners of German who worked on 3 distinct activity types over 16 months: free composition, translation, and sentence building. Study results reveal that grammatical accuracy with respect to German word order was significantly higher with the meaning‐focused task type (i.e., free composition) for both the beginner and intermediate levels. Moreover, proficiency level also had a significant effect on L2 word order accuracy: Beginner students performed significantly better than intermediate learners on the two form‐focused task types (i.e., translation and sentence building). With the ultimate goal of understanding learner performance as it relates to different task types and success in CALL, this article provides possible explanations of these study results and suggests areas for future development of task design in CALL.
The Zone of Proximal Development and the Genesis of Self‐Assessment
Authors: Poehner Matthew E. 
Published: December 2012

AbstractSelf‐assessment practices have become widespread in second language (L2) education, and while its proponents have long argued that such reflection enhances learner awareness of their abilities and promotes independent learning (Alderson, 2005; Chen, 2008; Little, 2007), others have questioned its value vis‐à‐vis other indicators of performance (Gipps, 1994; Ross, 1998). This article approaches learner self‐assessment from a Vygotskian perspective, and specifically the proposal of the Zone of Proximal Development (ZPD). According to this view, development is understood as transitioning from other‐regulated to self‐regulated functioning. Following Zuckerman (2003), engaging in reflective evaluation of performance is argued to be a critical feature of this process. Data from a study involving L2 learners of French participating in a Dynamic Assessment (Lantolf & Poehner, 2004) program are presented to explore how this development may occur and to examine challenges learners may experience as they endeavor to regulate not only their use of the L2 during completion of tasks but also while evaluating their performance. In keeping with the notion of the ZPD, it is argued that learner efforts to self‐assess must be carefully mediated as they move from a cooperative to an independent mode of self‐assessment.
Vocabulary and Grammar Knowledge in Second Language Reading Comprehension: A Structural Equation Modeling Study
Authors: ZHANG DONGBO 
Published: December 2012

AbstractUsing structural equation modeling analysis, this study examined the contribution of vocabulary and grammatical knowledge to second language reading comprehension among 190 advanced Chinese English as a foreign language learners. Vocabulary knowledge was measured in both breadth (Vocabulary Levels Test) and depth (Word Associates Test); grammatical measures focused on learners' implicit (timed grammaticality judgment task), as well as explicit knowledge (grammatical error correction task); reading comprehension had three indicators, namely, co‐reference, textual inference, and gist. Vocabulary knowledge related significantly to reading comprehension; grammatical knowledge showed a weak contribution to reading comprehension after controlling for the effect of vocabulary knowledge. In addition, learners' implicit knowledge of grammar had a stronger relationship to reading comprehension than explicit knowledge, over and above the effect of vocabulary size.
Nutritional Potential of Rice Bean (Vigna Umbellata): An Underutilized Legume
Authors: Katoch Rajan 
Published: December 2012

Abstract:  Rice bean, a less known and underutilized legume, has emerged as a potential legume because of its nutritional potential. The nutritional quality of rice bean is higher as compared to many other legumes of Vigna family. In the present study, 16 diverse rice bean genotypes were evaluated for major nutritional constituents viz; protein content, total lipids, dietary fiber, total carbohydrates, vitamins, minerals, protein fractions, amino acid, and fatty acid profile. The protein content to the extent of 25.57% was observed in the genotype BRS‐2 with in vitro digestibility of 54.23%. The fatty acid profile revealed the higher percentage of unsaturated fatty viz., linoleic and linolenic acid, which are nutritionally desirable in the diet. Albumins (6.13% to 7.47%) and globulins (13.11% to 15.56%) constituted the major portion of proteins. Anti‐nutritional factors were in the range of: total phenolics (1.63% to 1.82%), total tannins (1.37% to 1.55%), condensed tannins (0.75% to 0.80%), hydrolysable tannins (0.56% to 0.79%), trypsin inhibitor (24.55 to 37.23 mg/g), phytic acid (7.32 to 8.17 mg/g), lipoxygenase activity (703 to 950 units/mg), and saponin content (1.2 to 3.1 mg/100 g). The oligosaccharides associated with the production of flatulence viz., raffinose, stachyose, and verbascose were in the limits of 1.66% to 2.58%, 0.94% to 1.88%, and 0.85% to 1.23%, respectively. In vitro protein digestibility up to 55.57% was observed in rice bean genotypes. The present study has revealed that rice bean is a nutritionally rich legume as compared to many other legumes of the category. Among different genotypes BRS‐2 was observed superior and could be advocated for consumption as well as for inclusion in crop improvement programs.Practical Application:  Rice bean is nutritionally rich legume, but despite its nutritional excellence, it has been put in underutilized category. Because of this and several other reasons the people are not aware of its nutritional benefits. Moreover, the complete nutritional details are also not available on this pulse. The present study gives the vivid description of nutritional attributes of this legume for making people aware of its nutritional excellence and provoking improved work in rice bean.
Multiplex Real‐Time PCR Method for Detection and Quantification of Mycotoxigenic Fungi Belonging to Three Different Genera
Authors: Vegi Anuradha , Wolf‐Hall Charlene E. 
Published: December 2012

Abstract:  Cereal crop plants are colonized by many fungal species such as Aspergillus ochraceus and Penicillium verrucosum, which produce ochratoxins, and Fusarium graminearum, which produces trichothecene mycotoxins. A multiplex real‐time PCR method using TaqMan probes was developed to simultaneously detect and quantify these mycotoxigenic Fusarium, Penicillium and Aspergillus species in cereal grains. Primers and probes used in this method were designed targeting the trichothecene synthase (Tri5) gene in trichothecene‐producing Fusarium, rRNA gene in Penicillium verrucosum, and polyketide synthase gene (Pks) in Aspergillus ochraceus. The method was highly specific in detecting fungal species containing these genes and was sensitive, detecting up to 3 pg of genomic DNA. These PCR products were detectable over five orders of magnitude (3 pg to 30 ng of genomic DNA). The method was validated by evaluating sixteen barley culture samples for the presence of deoxynivalenol (DON) and ochratoxin A (OTA) producing fungi. Among the barley culture samples tested, 9 were positive for Fusarium spp, 5 tested positive for Penicillium spp, and 2 tested positive for Aspergillus spp. Results were confirmed by traditional microbiological methods. These results indicate that DON‐ and OTA‐producing fungi can be detected and quantified in a single reaction tube using this multiplex real‐time PCR method.Practical Application:  This method would be helpful in detecting and quantifying the mycotoxin producing fungi such as Fusarium, Aspergillus, and Penicillium in cereal grains and cereal‐based foods.