bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hidden Companions to Intermediate-mass Stars. XXI. Discovery of a 0.5 M
⊙, 1.5 au Companion to Sadachbia = Gamma Aquarii*
Authors: Waisberg Idel , Klein Ygal , Katz Boaz 
Published: August 2024

Abstract

Sadachbia = Gamma Aquarii is a nearby A0V star that was suspected to be a spectroscopic binary. Here we report on the direct detection of a companion with a K band flux ratio of 1.2% at a projected separation of 38.2 mas based on a VLTI/GRAVITY near-infrared interferometric observation. The implied mass and separation of the companion are 0.46 M
⊙ and 1.5 au based on the Gaia DR3 distance (or 0.55 M
⊙ and 1.9 au if the discrepant Hipparcos distance is used instead). The companion explains the X-ray emission of γ Aqr and the orbital motion with a period of about one year likely explains the discrepant Gaia and Hipparcos parallaxes. Further observations are necessary to measure the binary semimajor axis but it is likely that the system will undergo common envelope evolution. The primary is partially resolved with an angular diameter of 0.52 mas.
Effects of Perfluorohexane Sulfonate Exposure on Immune Cell Populations in Naive Mice
Authors: Pierpont Timothy M , Elmore Jessica , Redko Amie , Anannya Orchi , Imbiakha Brian , O’Hare Katelyn , Villanueva Alanis , Anronikov Sasha , Bondah Narda , Chang Sue , Sahler Julie , August Avery 
Published: August 2024

Abstract
Perfluorohexane sulfonate (PFHxS) is a member of the per- and polyfluoroalkyls (PFAS) superfamily of molecules, characterized by their fluorinated carbon chains and use in a wide range of industrial applications. PFHxS and perfluorooctane sulfonate are able to accumulate in the environment and in humans with the approximated serum elimination half-life in the range of several years. More recently, some PFAS compounds have also been suggested as potential immunosuppressants. In this study, we analyze immune cell numbers in mice following 28-d repeated oral exposure to potassium PFHxS at 12, 120, 1,200, and 12,000 ng/kg/d, with resulting serum levels ranging up to ∼1,600 ng/ml, approximating ranges found in the general population and at higher levels in PFAS workers. The immunosuppressant cyclophosphamide was analyzed as a positive control. B cells, T cells, and granulocytes from the bone marrow, liver, spleen, lymph nodes, and thymus were evaluated. We found that at these exposures, there was no effect of PFHxS on major T or B cell populations, macrophages, dendritic cells, basophils, mast cells, eosinophils, neutrophils, or circulating Ab isotypes. By contrast, mice exposed to cyclophosphamide exhibited depletion of several granulocyte and T and B cell populations in the thymus, bone marrow, and spleen, as well as reductions in IgG1, IgG2b, IgG2c, IgG3, IgE, and IgM. These data indicate that exposures of up to 12,000 ng/kg of PFHxS for 28 d do not affect immune cell numbers in naive mice, which provides valuable information for assessing the risks and health influences of exposures to this compound.
Vaccination with O-linked Mannans Protects against Systemic Candidiasis through Innate Lymphocyte Populations
Authors: Taira Cleison Ledesma , dos Santos Dias Lucas , Lichtenberger Sarah , Whitehead Alexander J , Kischkel Brenda , Netea Mihai G , Klein Bruce S , Wüthrich Marcel 
Published: August 2024

Abstract
Candida spp. are the fourth leading cause of bloodstream infections in hospitalized patients and the most common cause of invasive fungal infection. No vaccine against Candida spp. or other fungal pathogens of humans is available. We recently discovered the Blastomyces Dectin-2 ligand endoglucanase 2 that harbors antigenic and adjuvant functions and can function as a protective vaccine against that fungus. We also reported that the adjuvant activity, which is mediated by O-mannans decorating the C terminus of Blastomyces Dectin-2 ligand endoglucanase 2, can augment peptide Ag-induced vaccine immunity against heterologous agents, including Cryptococcus, Candida, and influenza. In this article, we report that the O-linked mannans alone, in the absence of any antigenic peptide, can also protect against systemic candidiasis, reducing kidney fungal load and increasing survival in a Dectin-2–dependent manner. We found that this long-term glycan-induced protection is mediated by innate lymphocyte populations including TCR-γδ+ T cells, innate lymphoid cells, and NK cells that subsequently activate and release reactive oxygen species from neutrophils and monocytes. Our findings suggest that Blastomyces O-mannan displayed by Eng2 induces a form of protective trained immunity mediated by innate lymphocyte populations.
Comorbidity of Mitral Valve Stenosis with Influenza in Pregnancy, A Case Report
Authors: Movahedi Minoo , Goharian Maryam , Kabiri Azita , Zamansaraei Shadi 
Published: August 2024

Abstract
In this case, a 44-year-old pregnant woman at a gestational age of 28 weeks and 6 days with symptoms of cold, shortness of breath, and cough since a week ago. She had received remdesivir ampoule, Tamiflu tablet, meropenem and linezolid, and dexamethasone. She received oxygen through a 14-liter reservoir bag mask and hydrocortisone, heparin, and ceftriaxone. Nine hours after hospitalization, the patient suffered a cardiorespiratory arrest, resuscitation was performed, and the patient was intubated. Emergency cesarean section was done in the intensive care unit. Finally, the patient suffered a cardiorespiratory arrest, prop was placed for the patient, and evidence of severe Mitral stenosis and right ventricle dilation were observed. The cardiopulmonary resuscitation operation continued for an hour, but unfortunately the patient died. So, it is important to be careful about influenza during pregnancy and in the case of heart failure symptoms, it is necessary to consider the presence of underlying mitral stenosis.
Low-Dose Atorvastatin has Promoting Effect on Melanoma Tumor Growth and Angiogenesis in Mouse Model
Authors: Vaseghi Golnaz , Ahmadzadeh Elmira , Naji Esfahani Hajar , Bahri Najafi Majed , Esmailian Nazgol , Haghjooy Javanmard Shaghayegh 
Published: August 2024

Abstract

Background:
Preclinical evidence indicates that statins possess diverse antineoplastic effects in different types of tumors. However, clinical studies have yielded conflicting results regarding the potential of statins to either increase or decrease the risk of cancer. Our objective was to examine the relationship between the dose of a treatment and its impact on melanoma tumor growth and angiogenesis in an in vivo setting.

Materials and Methods:
Melanoma cells were injected into C57BL6 mice in four groups. They received 0, 1, 5, and 10 mg/kg of atorvastatin daily. Three others received the mentioned doses one week before the inoculation of melanoma animals. At the end of the third week, the animals were euthanized in a humane manner, and both blood samples and tumor specimens were collected for subsequent analysis.

Results:
The tumor size was 1.16 ± 0.25 cm3 in a group treated with therapeutic dose of atorvastatin and was significantly larger than that in the control group (0.42 ± 0.08 cm3). However, there were no significant differences between the two other doses and the control group (0.72 ± 0.22, 0.46 ± 0.08 cm3 in atorvastatin-treated groups with 5 and 10 mg/kg). The vascular density of the tumors was significantly increased in the lowest dose of the atorvastatin treatment group, similar to the results of tumor size (P < 0.05).

Conclusion:
Atorvastatin, at low therapeutic concentrations, has been observed to stimulate tumor growth and exhibit pro-angiogenic effects. Therefore, it is advised to exercise caution and recommend clinically relevant doses of statins to patients with cancer.
The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients
Authors: Roayaei Mahnaz , Rezaei Mahmoud , Najafizade Nadia 
Published: August 2024

Abstract

Background:
Considering the prevalence of cetuximab-induced rashes in colorectal cancer patients and its impact on patient’s quality of life and treatment, this study aimed at investigating the effect of topical vitamin K1 on the treatment of skin rashes in metastatic colorectal cancer patients treated with cetuximab.

Materials and Methods:
This randomized, controlled, triple-blind, clinical trial was conducted on 49 metastatic colorectal cancer patients who were candidates for cetuximab treatment and referred to Omid Hospital in Isfahan during 2021–2022. Vitamin K1 cream with a concentration of 0.1% in the intervention group (n = 25) and placebo cream in the control group (n = 24) were prescribed twice a day (in the morning and before bedtime) for eight weeks. The rash grade was recorded based on common terminology criteria for adverse events-4 (CTCAE-4) criteria before the intervention and in the fourth and eighth weeks during the intervention.

Results:
During the intervention, skin rash grades in the fourth and eighth weeks with the means of 1.00 ± 0.64 and 0.84 ± 0.55, respectively, were significantly lower in the intervention group, as compared with the control group with the means of 1.42 ± 0.65 and 1.25 ± 0.68, respectively (P value < 0.05). Moreover, the severity of skin rashes decreased significantly in the intervention group over time during eight weeks (P value < 0.05); however, its decrease was not significant in the control group (P value > 0.05).

Conclusion:
Topical vitamin K1 cream had a significant effect on reducing the severity of cetuximab-induced skin rashes over eight weeks of treatment.
Clinical Outcomes of Double Mini-Plating Compared with a Single Superior Plating in Midshaft Clavicular Fractures: A Randomized Clinical Trial Study
Authors: Jafari Kafiabadi Meisam , Sabaghzadeh Amir , Barazandeh Rad Saber , Karami Amin , Sadighi Mehrdad , Biglari Farsad 
Published: August 2024

Abstract

Background:
In the current study, we aimed to assess the clinical outcomes of the double-plating method using 2.7 mm compression plates compared with the single superior 3.5 mm compression plating method in displaced midshaft fractures of the clavicle.

Materials and Methods:
Thirty patients with midshaft fractures of the clavicle were randomly assigned into two groups. In group A, 15 patients were fixed by a double-plating technique using two 2.7 mm compression plates on the superior and anteroinferior sides of the bone. The fractures in group B were fixed by a superior plating technique using a single 3.5 mm compression plate. Intraoperative bleeding measurement, length of surgical incision, duration of procedure time, and functional scores were assessed post-surgically through one-year follow-ups.

Results:
There was no significant difference between groups in terms of surgery time. Device failure was not found among all recruited patients. Incision length and device prominence complaint were significantly different between groups (P value = 0.02, P value = 0.03). Mean ± standard deviation intraoperative bleeding rate was 88.67 ± 29.96 milliliter in the double-plating group and 108.67 ± 41.72 milliliter in the other group, which was not different between these two groups (P value = 0.14). There were no signs of non-union either in radiographies or clinically.

Conclusion:
Double mini-plating of diaphyseal clavicular fractures could result in a smaller surgical incision and a lower rate of prominence without affecting fixation stability and clinical outcomes in comparison with single superior 3.5 mm plates.
Molecular Characteristics of TYK2 Gene Expressions in Patients with Colorectal Cancer
Authors: Mozooni Zahra , Mansouri Neda , Bafrani Freshteh , Kolahi Ali A. , Movafagh Abolfazl , Mirzaei Hamid Reza 
Published: August 2024

Abstract

Background:
TYK2 is a member of the JAK family and is known to mediate signals of multiple cytokines that play a crucial role in immune and inflammatory signaling. Activation of TYK2 in tumor cells has been linked to promote cell survival, growth, and invasion. This study aimed to investigate the expression of tyrosine kinase 2 (TYK2) in colorectal cancer (CRC) and adjacent control tissues.

Materials and Methods:
Quantitative Real-Time PCR (qRT-PCR) method was elaborated to examine the expression levels of TYK2 in 100 colorectal tumor tissues and adjacent tissues as a control. Furthermore, we analyzed the diagnostic power of the mentioned TYK2 by plotting the receiver operating characteristic (ROC) curve.

Results:
Our results revealed that the expression level of TYK2 was significantly up-regulated in CRC patients sample compared to the adjacent sample of the control group. Analysis of patient’s clinic pathological features shows that expressions TYK2 were differently associated with lymph vascular invasion and TMN stage (P < 0.0001, P < 0.0006).

Conclusion:
These results indicated that TYK2 levels potential biomarkers for diagnosing colorectal cancer may be identified.
In vitro Evaluation of Implant Impression Techniques and Elastomeric Materials: A Comparative Dimensional Accuracy Study
Authors: Khare Abhinav , Somkuwar Kirti , Yadav Naveen S , Saxena Abhishek , Verma Khushboo , Kashyap Rucha , Khare Himanshi 
Published: August 2024

Context:
Dimensional precision in implant impression.

Aims:
The purpose of this study was to comparatively evaluate the dimensional accuracy of two implant impression techniques with two different variants of vinyl polysiloxane impression material.

Material and Methods:
The edentulous mandible reference model was fabricated in clear resin. In the anterior region of the mandibular ridge, three dummy implants were placed in a spread-out configuration. Impressions were made using two elastomeric impression materials and two impression techniques using customised impression trays. Finished casts were then divided into four groups having four samples each. The mean centre-to-centre distances between adjacent analogues (in sample casts) and between adjacent implants (in the control cast) were measured with the help of a profile projector.

Statistical Analysis Used:
Data were analysed using Student’s t-test.

Results:
The open-tray technique showed more accurate results with a combination of medium body and light body, whereas in the closed tray technique, mono-phase vinyl polysiloxane appeared to be a better option. Amongst all, mono-phase with closed tray provided statistically significant results. P ˂ 0.05 in Group C and other group’s P ≥ 0.05.

Conclusions:
Within the limitations of this study, both implant impression techniques appeared to be equally accurate depending on clinical conditions, temperature and time of the procedure. However, mono-phase impression material with closed tray provided statistically significant results.
Strategies for Improving Nurses' Performance Regarding Cardiovascular Patient's Adherence to Treatment Regimen: Content Analysis
Authors: Parvizey Soroor , Nadery Yaghoub , Khorasani Parvaneh , Feizi Aram 
Published: August 2024

Background:
Patient adherence to the treatment regimen is an important goal of treatment; finding appropriate strategies to improve treatment adherence is a nursing challenge. This study aimed to explore strategies to improve nurses' performance to enhance cardiovascular patients' adherence to treatment regimens.

Materials and Methods:
This is a qualitative content analysis study that was performed in an educational hospital of the Urmia University of Medical Science. Data were collected through semi-structured individual and group interviews. Sixteen individual interviews were conducted with nurses, patients, and physicians. A focus group was conducted with the presence of six nurses and nursing managers. Data were analyzed by conventional content analysis using MAXQDA 2020.

Results:
After analyzing the interviews, five strategies were explored; these strategies include: follow-up of the patient after discharge (systemic and organizational follow-up, educational follow-up, counseling follow-up, and motivational follow-up), sending reminders for necessary cases to the patients (risk reminders, care reminders); improving patient education methods (modern and up-to-date education, conventional and routine education), improving support services (home care services, social support, Psychological support), and optimizing the structure and processes of the hospital (making structural changes, making process changes).

Conclusions:
Much needs to be done to improve patient's adherence to treatment. Nurses are at the forefront of this work. In this study, we introduced ways to improve nurses' performance in order to increase patient adherence.
Investigating the Relationship between Spiritual Intelligence and Resilience in Infertile Couples in Isfahan: A Cross-Sectional Study
Authors: Pirhadi Masoume , Torabi Fatemeh , Mokhtari Fatemeh 
Published: August 2024

Background:
Infertility is a psychological crisis for a couple, spouse, and their families. Due to the positive effects of spiritual intelligence on the positive adaptation and growth of the individual under difficult circumstances, this study was conducted to determine the relationship between spiritual intelligence and resilience in infertile couples in Isfahan.

Materials and Methods:
This cross-sectional study was performed in 2020 on 162 infertile couples. Data were collected by the convenience sampling method from infertile couples referring to Infertility Centers in Isfahan through two standard questionnaires. Data analysis was performed using descriptive statistical methods for quantitative variables. The relationship between spiritual intelligence and resilience score was investigated using inferential statistical methods of Pearson's correlation coefficient and multiple linear regression. A p value of less than 0.05 was considered significant.

Results:
The results showed that the mean age Standard Deviation (SD) of women and their spouses was 32.01 (5.86) and 36.30 (5.82) years, respectively. Pearson's correlation coefficient showed that there was a significant positive direct relationship between resilience score with total spiritual intelligence score (r = 0.36, p < 0.001) and its dimensions Critical Existential Thinking (CET) (r = 0.60, p < 0.001), personal meaning production (PMP) (r = 0.38, p < 0.001), Transcendental Awareness (TA) (r = 0.43, p < 0.001), and Conscious State Expansion (CSE) (r = 0.53, p < 0.001). The PMP (t = 6.38, p < 0.001) and the CSE (t = 2.15, p = 0.03) were significant predictors of resilience scores.

Conclusions:
The result of our study showed that couples with a higher level of spiritual intelligence had a better understanding of the problems and harms of primary infertility and would cope with it more efficiently.
Mobile Phone App-Based or Face-to-Face Pulmonary Rehabilitation in COVID-19 Survivors
Authors: Atashi Vajihe , Hashemi Marzieh , Haghighat Shila , Sadegh Raheleh , Sami Ramin , Bahadori Mobina 
Published: August 2024

Background:
Pulmonary Rehabilitation (PR) is recommended as a standard, effective, and important treatment for COVID-19 survivors who remain symptomatic after the acute phase. Therefore, we aimed to compare the effect of mobile phone-based PR application with face-to-face PR on the quality of life, anxiety, depression, and daily life activities of COVID-19 survivors.

Materials and Methods:
A quasi-experimental was conducted on 65 COVID-19 survivors during 2022. Convenient sampling was done based on the inclusion criteria. The intervention group (n = 31) received PR through a mobile phone application, and the control group (n = 34) received face-to-face PR. Data were collected before and after the intervention in both groups using a demographic information questionnaire, SF-12, the hospital anxiety and depression scale, and Barthel scale. For all tests, a maximum error of 5% was considered.

Results:
The two studied groups had no statistically significant difference with respect to all the investigated variables at baseline (p > 0.05). After the intervention, the mean anxiety and depression score of the patients in the control group was significantly lower than the intervention group (t = −3.46, f = 63, p = 0.01). After our intervention, there was no statistically significant difference in the mean quality of life and daily life activity scores between the two groups (t = −0.68, f = 63, p > 0.05).

Conclusions:
The application of PR does not show a statistically significant difference in terms of improving the quality of life and daily activities compared with the face-to-face method; we suggest that the PR application be used as a cost-effective method when face-to-face PR is not possible.
Javanese Women's Experiences during the First Pregnancy
Authors: Gayatri Mergy , Silvani Yulia , Pirade Roland A. , Akingbade Oluwadamilare , Harjo Indhar W. W. , Hastuti Nuraini R. 
Published: August 2024

Background:
Women experience physical, hormonal, and psychological changes during pregnancy. Similarly, some traditions are prevalent among Javanese women, which could affect their pregnancy. The experiences of first-time pregnant women in this area remain unclear. This study aimed to explore the lived experiences of women during their first pregnancy.

Materials and Methods:
The qualitative study with a phenomenological approach was conducted in Kesambon village in Malang Regency, Indonesia. Eight women in their third trimester were selected purposively. Data were gathered using semi-structured interviews and subsequently open-coded using the NVivo-12 software manufactured by the QS International.

Results:
The participants were married primigravida women aged 17 to 22 years. Four themes emerged as follows: pregnancy is a positive experience, pregnant women are not independent, belief in pregnancy-related myths and traditions, and pregnancy-related information seeking.

Conclusions:
During the first pregnancy, pregnant women believed and practiced Javanese traditions regarding pregnancy. Although they were happy, they were still dependent and lacked the motivation to seek pregnancy-related information. Hence, midwives should provide them with adequate pregnancy-related information while addressing harmful myths and misconceptions. This should culminate in a successful pregnancy.
Working Condition and Job Satisfaction of Nurses as Predicting Factors of the Prevalence of Health care-associated Infections among Elderly Inpatients
Authors: Rezaie Fereshteh , Mohammadi-Shahboulaghi Farahnaz , Fadayevatan Reza , Shati Mohsen , Ghaedamini-Harouni Gholamreza 
Published: August 2024

Background:
Health care-Associated Infections (HCAIs) are among the most common adverse events (AEs) that can negatively affect both patients and health systems. The elderly is among patients at high risk for infections. Some controllable risk factors have received less attention in research. Therefore, this study aims to investigate the relationship between prevalence of HCAIs among elderly inpatients, job satisfaction of nurses, and working condition.

Materials and Methods:
This cross-sectional study was conducted on 211 nurses working in hospitals affiliated with Iran University of Medical Sciences, Tehran, in 2021. The data were collected from HCAIs reports by the Nosocomial Infection Control Committee, a demographic questionnaire, the Practice Environment Scale of the Nursing Work Index (PES-NWI), and the Minnesota Satisfaction Questionnaire (MSQ). The data were statistically analyzed using Pearson correlation coefficient, ANOVA, t-test, and multiple linear regression (MLR) in SPSS 26.

Results:
The results showed that there was a significant relationship between the PES-NWI and MSQ (r = 0.68, p < 0.00). The MLR results indicated that staffing and resource adequacy, nurse participation in hospital affairs, job satisfaction, nursing manager's leadership, and nursing foundations for quality of care are predictive factors that these could explain 78% of the changes in the prevalence of HCAIs and the goodness of fit of the regression model was acceptable [F6.210 = 129.47, p < 0.001].

Conclusions:
Since job satisfaction and the work condition could predict HCAIs among the elderly patients, healthcare administers are recommended to consider these two variables in the development of HCAIs prevention and control programs.