bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Evaluation of a Modified Apnea Test in Brain Death Candidates that Does Not Require Disconnection from the Ventilator
Authors: Lambeck Johann , Bardutzky Jürgen , Strecker Christoph , Niesen Wolf-Dirk 
Published: July 2024

Abstract
Background
The apnea test (AT) is an important component in the determination of brain death/death by neurologic criteria (BD/DNC) and often entails disconnecting the patient from the ventilator followed by tracheal oxygen insufflation to ensure adequate oxygenation. To rate the test as positive, most international guidelines state that a lack of spontaneous breathing must be demonstrated when the arterial partial pressure of carbon dioxide (PaCO2) ≥ 60 mm Hg. However, the loss of positive end-expiratory pressure that is associated with disconnection from the ventilator may cause rapid desaturation. This, in turn, can lead to cardiopulmonary instability (especially in patients with pulmonary impairment and diseases such as acute respiratory distress syndrome), putting patients at increased risk. Therefore, this prospective study aimed to investigate whether a modified version of the AT (mAT), in which the patient remains connected to the ventilator, is a safer yet still valid alternative.

Methods
The mAT was performed in all 140 BD/DNC candidates registered between January 2019 and December 2022: after 10 min of preoxygenation, (1) positive end-expiratory pressure was increased by 2 mbar (1.5 mm Hg), (2) ventilation mode was switched to continuous positive airway pressure, and (3) apnea back-up mode was turned off (flow trigger 10 L/min). The mAT was considered positive when spontaneous breathing did not occur upon PaCO2 increase to ≥ 60 mm Hg (baseline 35–45 mm Hg). Clinical complications during/after mAT were documented.

Results
The mAT was possible in 139/140 patients and had a median duration of 15 min (interquartile range 13–19 min). Severe complications were not evident. In 51 patients, the post-mAT arterial partial pressure of oxygen (PaO2) was lower than the pre-mAT PaO2, whereas it was the same or higher in 88 cases. In patients with pulmonary impairment, apneic oxygenation during the mAT improved PaO2. In 123 cases, there was a transient drop in blood pressure at the end of or after the mAT, whereas in 12 cases, the mean arterial pressure dropped below 60 mm Hg.

Conclusions
The mAT is a safe and protective means of identifying patients who no longer have an intact central respiratory drive, which is a critical factor in the diagnosis of BD/DNC.
Clinical trial registration DRKS, DRKS00017803, retrospectively registered 23.11.2020, https://drks.de/search/de/trial/DRKS00017803
Sociodemographic Predictors of Sexual Communication and Sexual Communication as a Predictor of Sexual, Relationship, and Life Satisfaction in Denmark, Finland, France, Norway, Sweden, and the UK
Authors: Øverup Camilla S. , Hald Gert Martin , Pavan Silvia 
Published: July 2024

AbstractSexual communication is associated with higher levels of sexual and relationship satisfaction. However, research suggests that many struggle with sexual communication. Using a cross-country convenience sample of 7,139 respondents from six European countries (Denmark, Finland, France, Norway, Sweden, and the UK), we investigated sociodemographic predictors of different facets of sexual communication and their associations with sexual, relationship, and life satisfaction. Data was collected in May and June 2022 through respondent panels, by Cint, a market research software platform. Participants received an email invitation to the study and completed an online self-report survey. We found that a large proportion did report difficulties with sexual communication or a wish to improve such communication. We also found that sociodemographic factors predicted each facet (self-disclosure, frequency of communication, and quality of communication) of sexual communication as a set, but that the strongest predictors were sexual frequency and dissatisfaction with the low frequency of sex. Lastly, each facet of sexual communication was associated with higher levels of sexual, relationship, and life satisfaction. Across results, we generally found little cross-country variation.
Revisiting a Sixteenth-Century ‘Erotic’ Poem Wrongly Ascribed to Elizabeth Dacre
Authors: Ouwerkerk Aron L. 
Published: July 2024

AbstractThis article puts on trial the assumed authorship of a sixteenth-century manuscript poem reminiscent of Ovid’s Heroides, currently ascribed to Lady Elizabeth Dacre. After establishing a revised edition of the text, it provides arguments based on historical, material, literary and textual analyses of the source, strongly indicating the unlikeliness of its supposed attribution to this English noblewoman. The arguments suggest that, while Dacre was probably the scribe of the manuscript, the author of the text was most likely her husband, Sir Thomas Dacre. This outcome is used as an example evincing the fundamental importance of usable and informative text editions for historians and literary scholars alike, increasingly calling for close collaboration across disciplines, as well as a renewed appreciation of textual editing.
Ecosystem Carbon and Nutrient Balances in Short-Rotation Hybrid Aspen Coppice Under Different Thinning Methods
Authors: Lutter Reimo , Hepner Heiki , Tullus Arvo , Lim Hyungwoo , Tullus Tea , Õunapuu-Pikas Eele , Sopp Reeno , Kaivapalu Marju , Täll Kristjan , Ots Katri , Tullus Hardi 
Published: July 2024

AbstractCoppice plantations have gained a high interest for biofuel production and carbon uptake in short rotation cycles. There is a limited knowledge how such intensive coppice management affects soil fertility and nutrients supply to maintain carbon sink. We studied ecosystem carbon and nutrients balance and allocation during a 5-year period in hybrid aspen coppice under different thinning methods in hemiboreal Estonia. The benchmark value for the changes was defined before the coppice emerged after the clear-cut of the previously planted hybrid aspen plantation. The studied systematical thinning treatments were as follows: corridor thinning with removal of 67% of the trees (CT), cross-corridor thinning with removal of 89% of the trees (CCT), and unthinned (UT) coppice. The UT and CT treatments resulted in a positive carbon balance at the ecosystem level. In all treatments, a decrease of soil acidity, organic C, total N, K, Mg and Mn contents, and an increase of soil Cu and B contents were observed in the 0–20-cm deep layer. The concentrations of leaf N, P, and K were higher in UT than in the two thinning treatments, indicating that the aspens had not entirely recovered from the changed root to shoot ratio 2 years after thinning, whereas the leaf mass fraction of medium- and small-sized trees had already increased. Bioenergy harvest from the UT site in a 5-year rotation would cause 5–18% removal of NPK from the total ecosystem pool. Overall, hybrid aspen coppice showed positive ecosystem carbon balance after the first 5-year period; however, further monitoring of soil properties is needed as we found decrease of soil organic C and nutrients concentrations in short term.
Graphical Abstract
Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection
Authors: Mitchell Brooks I. , Yazel Eiser Isabelle E. , Kallianpur Kalpana J. , Gangcuangco Louie Mar , Chow Dominic C. , Ndhlovu Lishomwa C. , Paul Robert , Shikuma Cecilia M. 
Published: July 2024

Abstract

Background
HIV-associated neurocognitive disorders (HAND) is hypothesized to be a result of myeloid cell-induced neuro-inflammation in the central nervous system that may be initiated in the periphery, but the contribution of peripheral T cells in HAND pathogenesis remains poorly understood.

Methods
We assessed markers of T cell activation (HLA-DR + CD38+), immunosenescence (CD57 + CD28-), and immune-exhaustion (TIM-3, PD-1 and TIGIT) as well as monocyte subsets (classical, intermediate, and non-classical) by flow cytometry in peripheral blood derived from individuals with HIV on long-term stable anti-retroviral therapy (ART). Additionally, normalized neuropsychological (NP) composite test z-scores were obtained and regional brain volumes were assessed by magnetic resonance imaging (MRI). Relationships between proportions of immune phenotypes (of T-cells and monocytes), NP z-scores, and brain volumes were analyzed using Pearson correlations and multiple linear regression models.

Results
Of N = 51 participants, 84.3% were male, 86.3% had undetectable HIV RNA < 50 copies/ml, median age was 52 [47, 57] years and median CD4 T cell count was 479 [376, 717] cells/uL. Higher CD4 T cells expressing PD-1 + and/or TIM-3 + were associated with lower executive function and working memory and higher CD8 T cells expressing PD-1+ and/or TIM-3+ were associated with reduced brain volumes in multiple regions (putamen, nucleus accumbens, cerebellar cortex, and subcortical gray matter). Furthermore, higher single or dual frequencies of PD-1 + and TIM-3 + expressing CD4 and CD8 T-cells correlated with higher CD16 + monocyte numbers.

Conclusions
This study reinforces evidence that T cells, particularly those with immune exhaustion phenotypes, are associated with neurocognitive impairment and brain atrophy in people living with HIV on ART. Relationships revealed between T-cell immune exhaustion and inflammatory in CD16+ monocytes uncover interrelated cellular processes likely involved in the immunopathogenesis of HAND.
Topological properties of fractals via M-polynomial
Authors: Ishfaq Faiza , Nadeem Muhammad Faisal 
Published: July 2024

AbstractSierpiński graphs are frequently related to fractals, and fractals apply in several fields of science, i.e., in chemical graph theory, computer networking, biology, and physical sciences. Functions and polynomials are powerful tools in computer mathematics for predicting the features of networks. Topological descriptors, frequently graph constraints, are absolute values that characterize the topology of a computer network. In this essay, Firstly, we compute the M-polynomials for Sierpiński-type fractals. We derive some degree-dependent topological invariants after applying algebraic operations on these M-polynomials.
Evaluating Vulnerability of Supply Chain Networks to Capacity Reduction
Authors: Zarghami Seyed Ashkan , Dumrak Jantanee 
Published: July 2024

AbstractThe available studies on vulnerability evaluation of Supply Chain Networks (SCNs) oversimplify the availability of entities during disruptive events by classifying them into only two categories of “operational” and “not operational.” Yet, the literature has remained relatively silent on vulnerability analysis of SCNs in the case of capacity reduction. To sidestep this shortcoming, this paper develops an entropy-based method to quantify the vulnerability of SCNs to capacity reduction. This is achieved by measuring the flexibility inherent within the layout of SCNs, both at local and global levels. By performing simulation and sensitivity analyses, this paper predicts the impact of capacity reductions on the performance of SCNs. The results of our study favor the fact that incorporating more backups and increasing the capacity of various entities in the network reduces vulnerability and enhances the robustness of SCNs. The findings of this research may assist operations and supply chain managers in identifying the sensitive areas of SCNs, in turn facilitating the development of an effective risk management strategy to respond to disruptive events.
Digital Transformation and Flexible Performance Management: A Systematic Literature Review of the Evolution of Performance Measurement Systems
Authors: Cosa Marcello , Torelli Riccardo 
Published: July 2024

AbstractIn the era of digital transformation, businesses must innovate and adapt to sustain a competitive edge. This dynamic environment compels a reevaluation of traditional management practices, highlighting the need for highly flexible systems. Flexibility, defined as the ability to adapt organizational resources, processes, and strategies in response to environmental changes such as rapid technological advancements, is crucial. Our systematic review of 47 studies investigates how digital transformation influences performance measurement systems across various industries and global contexts. We found that digital transformation fosters the dynamism and adaptability of these systems. This study integrates strategic, organizational, and information systems flexibility concepts that are essential for effective adaptation and resilience. Our findings underscore the shifts towards decision-making agility, inclusivity, and sustainability, stressing the significant role of human resources in adapting to digital imperatives. We advocate for a comprehensive approach that fosters digital literacy, upholds ethical standards, promotes continuous skill development, and enhances strategic adaptability. Practical implications suggest integrating digital technologies into performance strategies, utilizing real-time metrics for agile decision-making and emphasizing ethical and sustainable practices to improve transparency and stakeholder trust. These strategies are crucial for optimizing performance in the digital age.
Universal distances for extended persistence
Authors: Bauer Ulrich , Botnan Magnus Bakke , Fluhr Benedikt 
Published: July 2024

AbstractThe extended persistence diagram is an invariant of piecewise linear functions, which is known to be stable under perturbations of functions with respect to the bottleneck distance as introduced by Cohen–Steiner, Edelsbrunner, and Harer. We address the question of universality, which asks for the largest possible stable distance on extended persistence diagrams, showing that a more discriminative variant of the bottleneck distance is universal. Our result applies more generally to settings where persistence diagrams are considered only up to a certain degree. We achieve our results by establishing a functorial construction and several characteristic properties of relative interlevel set homology, which mirror the classical Eilenberg–Steenrod axioms. Finally, we contrast the bottleneck distance with the interleaving distance of sheaves on the real line by showing that the latter is not intrinsic, let alone universal. This particular result has the further implication that the interleaving distance of Reeb graphs is not intrinsic either.
Dynamic factor models for claim reserving
Authors: Nomura Shunichi , Matsumori Yoshihiro 
Published: July 2024

AbstractThis study presents a new approach to claim reserving in the insurance industry using dynamic factor models (DFMs). Traditional methods often struggle to adapt to temporal variations in loss development, a gap that DFMs can effectively address. By employing DFMs on a multivariate time series of loss development factors (LDFs), we offer a more sensitive adaptation and understanding of loss development over time. Our methodology not only facilitates adjustment to trends in loss development but also provides clear explanations for the underlying reasons behind these trends. This aspect is crucial for actuaries, whose responsibilities include offering transparent and understandable reserve estimates. We apply the proposed DFMs to datasets from two different lines of business, demonstrating their ability to capture the temporal evolution of factors influencing loss development. The results indicate that our approach enhances fitting ability and provides deep insights into the dynamics of claim reserving. Furthermore, we assess the uncertainty in the ultimate loss amounts required for risk management to ensure financial stability and compliance with insurance regulatory requirements. This study contributes to the field of actuarial science by highlighting the potential of DFMs in enhancing the accuracy and reliability of claim reserving processes.
Memory Retrieval in Online Sentence Parsing: Empirical Evidence, Computational Modelling, and Simulations
Authors: Fujita Hiroki 
Published: July 2024

AbstractThis paper reports two experiments (Experiments 1 and 2) and computational simulations designed to investigate and model memory retrieval processes during real-time sentence processing. Central to this study is the hypothesis that linguistic information serves as a cue to retrieve target representations from memory during dependency formation. The basis for this cue-based memory retrieval stems from research showing that non-target representations that match a set of retrieval cues interfere with target retrieval. The susceptibility to this similarity-based interference has been debated in the sentence processing literature, and various hypotheses and models have been formulated and developed. This issue is addressed empirically in Experiments 1 and 2, which investigated similarity-based interference in sentences with a floating quantifier. Bayesian linear mixed models and Bayes factor analyses suggested similarity-based interference. However, the patterns of interference were not consistent with existing theories and models. To reconcile these findings within the framework of cue-based memory retrieval, this paper implements the Revision Integrated Cue-Based (RICB) model based on the ACT–R architecture. This model assumes that structural information is heavily weighted and incorporates the notions of initial retrieval and revision. The results of the simulations indicate that the RICB model successfully predicts the observed data, highlighting the central role of structural information and revision in memory retrieval during real-time sentence processing.
Numerical benchmark for road bridge damage detection from passing vehicles responses applied to four data-driven methods
Authors: Cantero Daniel , Sarwar Zohaib , Malekjafarian Abdollah , Corbally Robert , Alamdari Mehrisadat Makki , Cheema Prasad , Aggarwal Jatin , Noh Hae Young , Liu Jingxiao 
Published: July 2024

AbstractDrive-by bridge monitoring utilizes measured responses from passing vehicles to perform damage detection of bridge, a methodology challenged by multiple factors and operational conditions. Recently, data-driven methods have been used to improve the accuracy of drive-by monitoring. This thriving research field requires (but lacks) publicly available datasets to improve and validate its monitoring and damage detection capabilities. To foster data-driven drive-by bridge damage assessment methods, this document presents an openly available dataset consisting of numerically simulated vehicle responses crossing a range of bridge spans with various damage conditions. The dataset includes results for different monitoring scenarios, road profile conditions, vehicle models, vehicle mechanical properties and speeds. The intention is to provide a useful resource to the research community that serves as a reference set of results for testing and benchmarking new developments in the field. In addition, four recently published data-driven drive-by methods have been tested using the same dataset.
A rare case report of the Cowden syndrome
Authors: Mahiboob Sayyed , Gupta Rajesh 
Published: July 2024

AbstractCowden syndrome (CS) is a rare autosomal dominant genodermatosis caused by a heterozygous germline mutation in the PTEN gene, found in nearly 80% of cases. It is characterized by multiple benign hamartomas which manifest across various organs. This condition is further distinguished by its association with macrocephaly, facial trichilemmomas, acral keratoses, papillomatous papules, and a heightened susceptibility to certain malignant neoplasms, particularly affecting the thyroid, endometrium, and the breast (OMIM no. 58350).In this report, we detail the case of an Indian patient presenting with macrocephaly and multiple blackish pigmented areas on the face, alongside several small papules on the dorsum of the hands, and the presence of gastric and duodenal polyps, among other symptoms. Genetic analysis through Sanger sequencing of the PTEN gene revealed a heterozygous nonsense pathogenic variant (ENST00000371953.8: c.388C > T, p.Arg130Ter), thereby confirming a CS diagnosis. The report encompasses a comprehensive review of the existing literature, emphasizing the significance of genetic evaluation and discussing the intricacies of managing patients diagnosed with CS.
Optimal Baseflow Separation Through Chemical Mass Balance: Comparing the Usages of Two Tracers, Two Concentration Estimation Methods, and Four Baseflow Filters
Authors: Mei Yiwen , Wang Dagang , Zhu Jinxin , Tang Guoping , Cai Chenkai , Shen Xinyi , Hong Yi , Zhang Xinxuan 
Published: July 2024

AbstractOptimizing empirical baseflow filters using environmental tracers (e.g., specific electrical conductance (SEC), turbidity) is an effective and efficient way to quantify the contribution of baseflow to total flow. To execute this baseflow separation, three key components are needed: The tracer, the method to estimate tracer concentration in different flow components, and the empirical baseflow filter. However, a comprehensive evaluation of the various combinations of these components, especially with a large sample of catchments, is currently lacking in the literature. Therefore, our study assembles 16 hybrid baseflow filters from two tracers, two concentration estimation methods, and four empirical baseflow filters, and evaluated their performance in baseflow separation and producing two long‐term baseflow signatures for 1,100 catchments in the Contiguous United States. Our results suggest that SEC is a superior tracer to turbidity for baseflow separation. Additionally, using monthly maximum and minimum values to represent tracer concentration in flow components produces better separation than using a power function relationship between flow rate and concentration. The four empirical baseflow filters offer a similar level of performance, regardless of the other options used. Yet, some of these filters produce inconsistent results in calculating the baseflow signatures for the catchments. Our analysis shed light on the optimization of hybrid baseflow filters for the accurate quantification of baseflow contribution.