bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Long-Term Effects of Type 1 Diabetes Treatment and Complications on Health-Related Quality of Life
Authors: Jacobson Alan M. , Braffett Barbara H. , Cleary Patricia A. , Gubitosi-Klug Rose A. , Larkin Mary E. ,   the DCCT/EDIC Research Group
Published: July 2013

OBJECTIVE
To examine the long-term effects of type 1 diabetes treatment, metabolic control, and complications on health-related quality of life (HRQOL).

RESEARCH DESIGN AND METHODS
A total of 1,441 participants, initially 13–39 years of age, were followed for an average of 23.5 years as part of the Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study. The Diabetes Quality-of-Life questionnaire (DQOL) was administered annually during DCCT and every other year during EDIC. Biomedical data, including HbA1c levels, exposure to severe hypoglycemia, intercurrent psychiatric events, and development of diabetes complications were collected at regular intervals throughout the follow-up.

RESULTS
Mean total DQOL scores were not significantly different between the former DCCT intensive and conventional treatment groups (DCCT baseline, 78 ± 8 vs. 78 ± 9; EDIC year 17, 75 ± 11 vs. 74 ± 11). Over the course of the study, a drop of ≥5 points in DQOL score from DCCT baseline maintained on two successive visits occurred in 755 individuals and was associated with increased HbA1c, albumin excretion rate, mean blood pressure, BMI, and occurrence of hypoglycemic events requiring assistance. Lower DQOL scores after 23.5 years of follow-up were associated with prior development of retinopathy (P = 0.0196), nephropathy (P = 0.0019), and neuropathy (P &lt; 0.0001) as well as self-reported chest pain (P = 0.0004), decreased vision in both eyes (P = 0.0005), painful paresthesias (P &lt; 0.0001), recurrent urinary incontinence (P = 0.0001), erectile dysfunction (P &lt; 0.0001), and history of psychiatric events (P &lt; 0.0001).

CONCLUSIONS
Among DCCT/EDIC participants, worsening metabolic control, serious diabetes complications and their associated symptoms, and development of psychiatric conditions led to decreased HRQOL.
Use of doping agents and symptoms of eating disorders among male and female patients in drug addiction treatment
Authors: N⊘kleby Heid 
Published: July 2013

Aims This study investigates the prevalence of use of doping agents and symptoms of eating disorders among patients in drug addiction treatment. The aim is also to look for characteristics of the groups reporting the use of doping agents or symptoms of eating disorders. Design A survey including questions on exercise, the use of doping agents and Eating Disorder Inventory-2 was administered in a Norwegian drug addiction facility. The study included 109 patients in residential drug treatment, 30 females and 79 males (ranging from 17 to 50 years old). Results –Symptoms of eating disorders were reported by 33 percent of the females and 7.6 percent of the males. Previous use of doping agents (anabolic-androgenic steroids in particular) was reported by 40.5 percent of the men and 20 percent of the women. The results are discussed in light of the theory on emotion regulation, gender and cultural expectations, drug treatment as a liminal phase and similarities to drug addiction. Conclusions The symptoms of eating disorders and the use of doping agents are prevalent in this sample of male and female drug addicts in treatment. Drug treatment facilities should be aware of this and take the appropriate actions regarding attention, screening and treatment.
Mercury associated with size-fractionated urban particulate matter: three years of sampling in Prague, Czech Republic
Authors: Zvěřina Ondřej , Coufalík Pavel , Komárek Josef , Gadas Petr , Sysalová Jiřina 
Published: July 2013

AbstractAn analysis of suspended particulate matter, with an emphasis on the Hg chemical forms, is presented. Dust samples originating from an area highly affected by traffic pollution in the city of Prague (Czech Republic) were sampled over a period of three years from air-conditioner filters and fractioned by size. The samples were morphologically characterised by scanning electron microscopy. The main method used for the analysis of constituent mercury compounds was sequential extraction by leaching solutions in combination with thermal desorption. The total mercury content ranged from 0.37 mg kg−1 to 0.82 mg kg−1. It emerged that the mercury was distributed in a wide spectrum of forms, and various trends in the distribution of these forms among the different size classes were observed. The fraction leached by nitric acid (consisting of elemental and complex-bound mercury) was the main constituent of total mercury. The highest content of this fraction was observed in the finest particle size class. The heterogeneity of morphology of the material increased with the size fraction.
Polycarbonate-based polyurethane elastomers: temperature-dependence of tensile properties
Authors: Hrdlička Zdeněk , Kuta Antonín , Poręba Rafał , Špírková Milena 
Published: July 2013

AbstractNovel polyurethane thermoplastic elastomers were prepared from polycarbonate diols, butane-1,4-diol (chain extender) and hexamethylene diisocyanate. They differ in the kind of macrodiol used and the ratio of macrodiol to chain extender OH groups (hence, in hard segment contents). The tensile properties of the elastomers at low and elevated temperatures were determined and discussed with regard to polyurethane composition and polycarbonate diol structure.
Synthesis, characterization and photoluminescence properties of Ce3+-doped ZnO-nanophosphors
Authors: Shukla Sudheesh , Agorku Eric , Mittal Hemant , Mishra Ajay 
Published: July 2013

AbstractThe present study involves the synthesis of Ce3+ doped ZnO nanophosphors by the zinc nitrate and cerium nitrate co-precipitation method. The synthesized nanophosphors were characterized with respect to their crystal structure, crystal morphology, particle size and photoluminescence (PL) properties using X-ray diffraction (XRD), scanning electron microscopy (SEM)/energy dispersive X-ray (EDX), transmission electron microscopy (TEM)/Energy-dispersive X-ray spectroscopy (EDS) and PL-spectroscopy respectively. XRD results revealed that ZnO nanophosphors are single phase and cubic type structures. Further, PL spectra of ZnO:Ce3+ nanophosphors showed green emission because of the charge transfer at single occupied oxygen vacancies with ZnO holes and red emission due to the cerium ion transitions. Intensity and fine structure of the Ce3+ luminescence and its temperature dependence are strongly influenced by the doping conditions. The formation of ZnO:Ce3+ nanophosphors was confirmed by Fourier transform infrared (FTIR) and XRD spectra.
Efficient thioacetalisation of carbonyl compounds
Authors: Habibi Davood , Rahmani Payam , Akbaripanah Ziba 
Published: July 2013

AbstractThe thioacetalisation of a variety of heterocyclic, aromatic, and aliphatic carbonyl compounds (1 mmol) with ethane-1,2-dithiol (1 mmol) using silica sulphuric acid (SSA) is presented as an efficient heterogeneous catalyst under mild and solvent-free conditions at 60°C. The thioacetals were formed within a short reaction time (1–34 min) and isolated with 90–98 % yield following an extractive procedure and chromatography on silica gel. The competitive protection reaction between aldehyde and ketone with ethane-1,2-dithiol afforded the protected derivatives of benzaldehyde and acetophenone with 92 % and 8 % yields, respectively, indicating some selectivity.
Influence of operating conditions on performance of ceramic membrane used for water treatment
Authors: Urbanowska Agnieszka , Kabsch-Korbutowicz Małgorzata 
Published: July 2013

AbstractThe removal of natural organic matter (NOM) is a critical aspect of potable water treatment because NOM compounds are precursors of harmful disinfection by-products, hence should be removed from water intended for human consumption. Ultrafiltration using ceramic membranes can be a suitable process for removal of natural substances. Previously reported experiments were dedicated to evaluating the suitability of ultrafiltration through ceramic membrane for water treatment with a focus on the separation of natural organic matter. The effects of the membrane operating time and linear flow velocity on transport and separation properties were also examined. The experiments, using a 7-channel 300 kDa MWCO ceramic membrane, were carried out with model solutions and surface water at trans-membrane pressure of 0.2–0.5 MPa. The results revealed that a loose UF ceramic membrane can successfully eliminate natural organic matter from water. The permeability of the membrane was strongly affected by the composition of the feed stream, i.e. the permeate flux decreased with an increase in the NOM concentration. The permeate flux also decreased over the period of the operation, while this parameter did not influence the effectiveness of separation, i.e. the removal of NOM. It was observed that the increased cross-flow velocity resulted in the decrease in the membrane-fouling intensity and slightly improved the retention of contaminants.
Synthesis and photophysical properties of new Ln(III) (Ln = Eu(III), Gd(III), or Tb(III)) complexes of 1-amidino-O-methylurea
Authors: Singh L. , Singh R. 
Published: July 2013

AbstractThree new solid lanthanide(III) complexes, [Ln(1-AMUH)3] · (NO3)3 (1-AMUH = 1-amidino-O-methylurea; Ln = Eu(III), Gd(III), or Tb(III)) were synthesised and characterised by elemental analysis, infrared spectra, magnetic moment measurement, and electron paramagnetic resonance (EPR) spectra for Gd(III) complex. The formation of lanthanide(III) complexes is confirmed by the spectroscopic studies. The photophysical properties of Gd(III), Eu(III), and Tb(III) complexes in solid state were investigated. The Tb(III) complex exhibits the strongest green emission at 543 nm and the Eu(III) complex shows a red emission at 615 nm while the Gd(III) complex shows a weak emission band at 303 nm. Under excitation with UV light, these complexes exhibited an emission characteristic of central metal ions. The powder EPR spectrum of the Gd(III) complex at 300 K exhibits a single broad band with g = 2.025. The bi-exponential nature of the decay lifetime curve is observed in the Eu(III) and Tb(III) complexes. The results reveal them to have potential as luminescent materials.
INTERPRETACJE. Popędy i metafizyka O Przygodach Witolda Gombrowicza / Drives and Meta Physics Witold Gombrowicz’s Adventures
Authors: Tischner Łukasz 
Published: July 2013

Summary
This interpretation of Witold Gombrowicz’s Adventures tries to throw light on the foundations of its author’s artistic imagination. It is important in so far as each new addition to Gombrowicz’s oeuvre can be regarded as an attempt to recover the grounds of the ‘Time of Immaturity’, the starting point of his literary quest. Adventures, which is one of the stories of the Memoirs from a Time of Immaturity, can be classified as a fable about omnipotence. Following Andrzej Kijowski, the author of this article re-examines the double code used in this story: it can be read within the framework of (Freudian) psychoanalysis and, alternatively, that of theology (as the omnipotence reflects the relationship of the Demiurge to his creation).
Book Reviews
Authors: Nielsen Katherine , Perry Beth , Scott Alan 
Published: July 2013

Lynette Shultz, Ali A. Abdi, George H. Richardson (eds) (2011) Global Citizenship Education in Post-secondary Institutions: Theories, Practices, PoliciesReview by Katherine NielsenPeter Quiddington (2010) Knowledge and Its Enemies: Towards a New Case for Higher LearningReview by Beth PerryBenjamin Ginsberg (2011) The Fall of the Faculty: The Rise of the All-Administrative University and Why it MattersReview by Alan Scott
Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay
Authors: Rathnasamy Selestin , Mohamed Kamaruzaman Bin , Sulaiman Shaida Fariza , Akinboro Akeem 
Published: July 2013

In the present study, the Allium cepa chromosome assay was employed as a preliminary test to investigate the mutagenic and antimutagenic potential of three plants, namely Clinacanthus nutans, Adhatoda vasica, and Carica papaya, used by traditional practitioners in Malaysia against a direct acting mutagen-Methyl Methanesulphonate (MMS). Onions were planted in various treatment groups: plant extract alone, treatment 1 (pre-treatment with MMS and transfer into plant extracts), and treatment 2 (mixture of MMS and plant extracts). The bulbs planted in the extract alone for cytotoxicity and mutagenicity assessment revealed that none of the extracts of the three plants except the 50 mg/kg of methanol extract of A. vasicawere cytotoxic to A. cepa cells, but a moderate level of mutagenicity was observed at 200 and 400 mg/kg of methanol extract of C. papaya and at 400 mg/kg of aqueous extract of C. nutans. Antimutagenic screening on the other hand revealed that all the extracts tested were able to reduce the percentage chromosomal aberration induced by MMS, both in treatment 1 and 2. Besides that, MMS-induced cell death was also observed to be reduced in onion root cells treated with the plant extracts. Therefore, taking all the results obtained into consideration, the order of the plant extracts with increasing suppressiveness against MMS was C. papaya < A. vasica < C. nutans.DOI: http://dx.doi.org/10.3329/icpj.v2i8.15588 International Current Pharmaceutical Journal, July 2013, 2(8): 131-140
Development and validation of UV spectrophotometric method for quantitative estimation of Promethazine HCl in phosphate buffer saline pH 7.4
Authors: Nurahmanto Dwi 
Published: July 2013

A new, sensitive, rapid, simple, specific and economical procedure has been developed for determination Promethazine HCl in phosphate buffer saline pH 7.4. The purpose of this analytical validation procedure is to determine a process of assessment and to validate it by laboratory experiments to prove that the method meets the minimum standard for laboratory use. This analytical method for the determination of Promethazine HCl in phosphate buffer saline pH 7.4 can be used to estimate the amount of promethazine HCl penetrated and dissolved in the blood vessels in vitro by penetration study. The method is based on the ultraviolet light absorbance at 251 nm which is the maximum wavelength of the concerned drug. This method can be succesfully applied for determination of drug in phosphate buffer saline pH 7.4 . The results of the analysis have been validated statistically and by recovery studies.DOI: http://dx.doi.org/10.3329/icpj.v2i8.15589 International Current Pharmaceutical Journal, July 2013, 2(8): 141-142
L’ethnographie et l’anthropologie religieuses de Cuba : repères historiques et bibliographiques
Authors: Gobin Emma , Morel Géraldine 
Published: July 2013

Le développement que connaissent aujourd’hui les études sur Cuba, en particulier l’ethnographie des pratiques religieuses dites « d’origine africaine », n’est pas le fruit du hasard. Cet article introductif revient sur les conditions sociohistoriques spécifiques qui ont présidé à ce renouveau en les replaçant dans le contexte politique et idéologique cubain. Afin d’établir quelques repères bibliographiques dans un domaine d’études devenu particulièrement dynamique, il évoque aussi certaines tendances de la production scientifique relative aux religions cubaines en répertoriant et en commentant plusieurs études conduites récemment. Selon qu’elles proviennent des États-Unis, d’Europe ou de Cuba, ces dernières témoignent de sensibilités diverses qui sont brièvement pointées avant de présenter les principales caractéristiques du champ religieux « afro-cubain » puis d’évoquer les thématiques qui émergent de ce numéro, également représentatives de certaines orientations de l’anthropologie religieuse contemporaine.
Primary Vascularization of Allografts Governs Their Immunogenicity and Susceptibility to Tolerogenesis
Authors: Kant Cavit D. , Akiyama Yoshinobu , Tanaka Katsunori , Shea Susan , Connolly Sarah E. , Germana Sharon , Winn Henry J. , LeGuern Christian , Tocco Georges , Benichou Gilles 
Published: July 2013

Abstract
We investigated the influence of allograft primary vascularization on alloimmunity, rejection, and tolerance in mice. First, we showed that fully allogeneic primarily vascularized and conventional skin transplants were rejected at the same pace. Remarkably, however, short-term treatment of mice with anti-CD40L Abs achieved long-term survival of vascularized skin and cardiac transplants but not conventional skin grafts. Nonvascularized skin transplants triggered vigorous direct and indirect proinflammatory type 1 T cell responses (IL-2 and IFN-γ), whereas primarily vascularized skin allografts failed to trigger a significant indirect alloresponse. A similar lack of indirect alloreactivity was also observed after placement of different vascularized organ transplants, including hearts and kidneys, whereas hearts placed under the skin (nonvascularized) triggered potent indirect alloresponses. Altogether, these results suggest that primary vascularization of allografts is associated with a lack of indirect T cell alloreactivity. Finally, we show that long-term survival of vascularized skin allografts induced by anti-CD40L Abs was associated with a combined lack of indirect alloresponse and a shift of the direct alloresponse toward a type 2 cytokine (IL-4, IL-10)-secretion pattern but no activation/expansion of Foxp3+ regulatory T cells. Therefore, primary vascularization of allografts governs their immunogenicity and tolerogenicity.
Human Skin Mast Cells Express Complement Factors C3 and C5
Authors: Fukuoka Yoshihiro , Hite Michelle R. , Dellinger Anthony L. , Schwartz Lawrence B. 
Published: July 2013

AbstractWe examine whether complement factor C3 or C5 is synthesized by human skin–derived mast cells and whether their synthesis is regulated by cytokines. C3 and C5 mRNAs were assessed by RT-PCR, and proteins by flow cytometry, confocal microscopy, Western blotting, and ELISA. C3 and C5 mRNAs were each expressed, and baseline protein levels/106 cultured mast cells were 0.9 and 0.8 ng, respectively, and located in the cytoplasm outside of secretory granules. C3 accumulated in mast cell culture medium over time and by 3 d reached a concentration of 9.4 ± 8.0 ng/ml, whereas C5 levels were not detectable (&lt;0.15 ng/ml). Three-day incubations of mast cells with IL-1α, IL-1β, IL-17, IFN-γ, IL-6, or anti-FcεRI did not affect C3 protein levels in culture medium, whereas incubations with PMA, TNF-α, IL-13, or IL-4 enhanced levels of C3 1.7- to 3.3-fold. In contrast with C3, levels of C5 remained undetectable. Importantly, treatment with TNF-α together with either IL-4 or IL-13 synergistically enhanced C3 (but not C5) production in culture medium by 9.8- or 7.1-fold, respectively. This synergy was blocked by attenuating the TNF-α pathway with neutralizing anti–TNF-α Ab, soluble TNFR, or an inhibitor of NF-κB, or by attenuating the IL-4/13 pathway with Jak family or Erk antagonists. Inhibitors of PI3K, Jnk, and p38 MAPK did not affect this synergy. Thus, human mast cells can produce and secrete C3, whereas β-tryptase can act on C3 to generate C3a and C3b, raising the likelihood that mast cells engage complement to modulate immunity and inflammation in vivo.
Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells
Authors: Wang Hong , Henry Olivier , Distefano Mark D. , Wang Yen-Chih , Räikkönen Johanna , Mönkkönen Jukka , Tanaka Yoshimasa , Morita Craig T. 
Published: July 2013

AbstractMost human γδ T cells express Vγ2Vδ2 TCRs and play important roles in microbial and tumor immunity. Vγ2Vδ2 T cells are stimulated by self- and foreign prenyl pyrophosphate intermediates in isoprenoid synthesis. However, little is known about the molecular basis for this stimulation. We find that a mAb specific for butyrophilin 3 (BTN3)/CD277 Ig superfamily proteins mimics prenyl pyrophosphates. The 20.1 mAb stimulated Vγ2Vδ2 T cell clones regardless of their functional phenotype or developmental origin and selectively expanded blood Vγ2Vδ2 T cells. The γδ TCR mediates 20.1 mAb stimulation because IL-2 is released by β− Jurkat cells transfected with Vγ2Vδ2 TCRs. 20.1 stimulation was not due to isopentenyl pyrophosphate (IPP) accumulation because 20.1 treatment of APC did not increase IPP levels. In addition, stimulation was not inhibited by statin treatment, which blocks IPP production. Importantly, small interfering RNA knockdown of BTN3A1 abolished stimulation by IPP that could be restored by re-expression of BTN3A1 but not by BTN3A2 or BTN3A3. Rhesus monkey and baboon APC presented HMBPP and 20.1 to human Vγ2Vδ2 T cells despite amino acid differences in BTN3A1 that localize to its outer surface. This suggests that the conserved inner and/or top surfaces of BTN3A1 interact with its counterreceptor. Although no binding site exists on the BTN3A1 extracellular domains, a model of the intracellular B30.2 domain predicts a basic pocket on its binding surface. However, BTN3A1 did not preferentially bind a photoaffinity prenyl pyrophosphate. Thus, BTN3A1 is required for stimulation by prenyl pyrophosphates but does not bind the intermediates with high affinity.
Regulation of Dendritic Cell Differentiation in Bone Marrow during Emergency Myelopoiesis
Authors: Liu Hao , Zhou Jie , Cheng Pingyan , Ramachandran Indu , Nefedova Yulia , Gabrilovich Dmitry I. 
Published: July 2013

Abstract
Although accumulation of dendritic cell (DC) precursors occurs in bone marrow, the terminal differentiation of these cells takes place outside bone marrow. The signaling, regulating this process, remains poorly understood. We demonstrated that this process could be differentially regulated by Notch ligands: Jagged-1 (Jag1) and Delta-like ligand 1 (Dll1). In contrast to Dll1, Jag1, in vitro and during induced myelopoiesis in vivo, prevented DC differentiation by promoting the accumulation of their precursors. Although both ligands activated Notch in hematopoietic progenitor cells, they had an opposite effect on Wnt signaling. Dll1 activated Wnt pathways, whereas Jag1 inhibited it via downregulation of the expression of the Wnt receptors Frizzled (Fzd). Jag1 suppressed fzd expression by retaining histone deacetylase 1 in the complex with the transcription factor CSL/CBF-1 on the fzd promoter. Our results suggest that DC differentiation, during induced myelopoiesis, can be regulated by the nature of the Notch ligand expressed on adjacent stroma cells.
Dispersion State and Fiber Toughness: Antibacterial Lysozyme‐Single Walled Carbon Nanotubes
Authors: Horn Daniel W. , Ao Geyou , Maugey Maryse , Zakri Cécile , Poulin Philippe , Davis Virginia A. 
Published: July 2013

AbstractNovel multicomponent fibers that include single‐walled carbon nanotubes (SWNT) and lysozyme (LSZ) are reported. These fibers exhibit antibacterial and mechanical properties suitable for fabrics, clothing and technical textiles in medical environments. The challenging combination of several components in a single fiber material is achieved via fundamental studies on the phase behavior of aqueous LSZ–SWNT dispersions. The addition of molecular cationic surfactants proved to be critical to achieving stable liquid mixtures that can be spun into fibers. In the absence of the cationic surfactant tetradecyl trimethylammonium bromide (TTAB), depletion effects result in large aggregates at relatively low SWNT concentration. However, the addition of TTAB increases the concentration at which demixing occurrs by approximately one order of magnitude. Dry‐spun fibers with significant antibacterial activity and toughness are obtained from LSZ–TTAB–SWNT dispersions combined with a polyvinyl alcohol (PVA) solution. Toughness is strongly affected by the initial dispersion state. The most remarkable fibers are produced from concentrated LSZ–TTAB–SWNT supernatants; they both have four times the toughness of spider silk and 70% of the native LSZ activity.