bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of music therapy compared with general recreational activities in reducing agitation in people with dementia: a randomised controlled trial
Authors: Vink A. C. , Zuidersma M. , Boersma F. , de Jonge P. , Zuidema S. U. , Slaets J. P. J. 
Published: December 2012

ObjectiveThis study aimed to compare the effects of music therapy with general recreational day activities in reducing agitation in people with dementia, residing in nursing home facilities.MethodsIn a randomised controlled design, residents with dementia (n = 94) were allocated to either music therapy or recreational activities. Both music therapy and general activities were offered twice weekly for 4 months. Changes in agitation were measured with a modified Cohen‐Mansfield Agitation Inventory (CMAI) at four intervals on each intervention day. A mixed model analysis was used to evaluate the effectiveness of music therapy, compared with general activities, on CMAI scores at 4 h after the intervention, controlled for CMAI scores at 1 h before the session and session number.ResultsData were analysed for 77 residents (43 randomised to music therapy and 34 to general activities). In both groups, the intervention resulted in a decrease in agitated behaviours from 1 h before to 4 h after each session. This decrease was somewhat greater in the music therapy group than in the general activities group, but this difference was statistically not significant (F = 2.885, p = 0.090) and disappeared completely after adjustment for Global Deterioration Scale stage (F = 1.500; p = 0.222).ConclusionsBoth music therapy and recreational activities lead to a short‐term decrease in agitation, but there was no additional beneficial effect of music therapy over general activities. More research is required to provide insight in the effects of music therapy in reducing agitation in demented older people. Copyright © 2012 John Wiley & Sons, Ltd.
A multi‐scale hydroclimatic analysis of runoff generation in the Athabasca River, western Canada
Authors: Peters Daniel L. , Atkinson David , Monk Wendy A. , Tenenbaum David E. , Baird Donald J. 
Published: December 2012

AbstractA multi‐scale hydroclimatic study of runoff generation in the Athabasca River watershed located in western Canada is presented. Mann–Kendall trend detection tests performed on hydrometric data for the lower Athabasca River (LAR) revealed predominantly significant (p < 0.05) declines in annual and open‐water season median/mean runoff indices over 1958–2009, with the ice‐influenced season experiencing significant declines in the median and not the mean. The presence or absence of significant declines in the 25thand 75thrunoff percentiles helped explain these results. The only noteworthy result from the mid‐point of the watershed was a probable (p < 0.10) decline in median open‐water runoff, which was not seen over the 1913–2009 period. Divergent seasonal runoff trends from the headwater zone were seen since 1958 and back to 1913, increasing ice‐influenced and declining open‐water season runoff trends. Although precipitation was observed to decline over 1958–2009, only the LAR watershed scale annual index emerged as a probable decline. Multiple non‐linear regression analysis indicated that variation in precipitation explained >67% of the annual median/mean LAR runoff variability since 1958. A first‐order precipitation driven hindcasting model suggested that LAR watershed scale runoff may have increased since 1913, warranting further study. A correlation analysis of climatic teleconnections with median/mean runoff indices revealed that the winter North Pacific American index showed a strong, positive association with open‐water runoff. The results from our study demonstrated that potentially inconsistent and/or divergent trend results can be obtained when using different time periods and/or regions of the watershed, emphasizing that extreme caution should be exercised when extrapolating sub‐watershed results to the watershed scale, or to adjacent watersheds. Our multi‐scale study approach also identified the drainage area between Athabasca and Fort McMurray as a zone that influenced runoff declines observed at the LAR watershed scale since 1958, which warrants further investigation with competent hydrological models. Copyright © 2013 John Wiley & Sons Ltd and Her Majesty the Queen in Right of Canada Reproduced with the permission of the Ministry of the Environment.
Quantitative diagnosis of cervical neoplasia using fluorescence lifetime imaging on haematoxylin and eosin stained tissue sections
Authors: Gu Jun , Fu Chit Yaw , Ng Beng Koon , Gulam Razul Sirajudeen , Lim Soo Kim 
Published: December 2012

AbstractThe use of conventional fluorescence microscopy for characterizing tissue pathological states is limited by overlapping spectra and the dependence on excitation power and fluorophore concentration. Fluorescence lifetime imaging microscopy (FLIM) can overcome these limitations due to its insensitivity to fluorophore concentration, excitation power and spectral similarity. This study investigates the diagnosis of early cervical cancer using FLIM and a neural network extreme learning machine classifier. A concurrently high sensitivity and specificity of 92.8% and 80.2%, respectively, were achieved. The results suggest that the proposed technique can be used to supplement the traditional histopathological examination of early cervical cancer. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Abusive supervision and feedback avoidance: The mediating role of emotional exhaustion
Authors: Whitman Marilyn V. , Halbesleben Jonathon R. B. , Holmes Oscar 
Published: December 2012

SummaryThe occurrence of abusive supervision is steadily rising. Extant literature continues to expand the number of destructive consequences linked to such improper workplace behavior. This study tested a model linking abusive supervision to feedback avoidance through emotional exhaustion. We invoked conservation of resources theory in our examination of the role that the loss of valued resources plays in instances where abuse is perceived. Results from three rounds of matched data from 460 nurses and 220 working adults demonstrated support for our model, suggesting a mediating effect for exhaustion on the relationship between abuse and feedback avoidance. Findings also revealed that feedback avoidance was associated with subsequent exhaustion, representing a loss spiral. These findings are important as they reveal the link between a subordinate's reactions (exhaustion) and coping behavior (feedback avoidance) when supervisory abuse is perceived. Theoretical and practical implications, limitations, and directions for future research are offered. Copyright © 2012 John Wiley & Sons, Ltd.
An evaluation of post‐lumpectomy recurrence rates: Is follow‐up every 6 months for 2 years needed?
Authors: McNaul David , Darke Maxine , Garg Megha , Dale Paul 
Published: December 2012

AbstractBackground and ObjectivesThere is currently debate about the optimal timing and frequency of mammography follow‐up after breast‐conserving therapy (BCT). The purpose of this study was to determine if 6‐month intervals for the first 2 years following BCT offer benefit over annual screening.MethodsThree hundred ninety‐nine patients who had lumpectomies between 1997 and 2009 and who were followed for at least 2 years with mammography were selected. The mammography yields for the first 2 years following BCT were compared to those of the general screening population. Also, patients were grouped as either compliant or noncompliant with the recommended 6‐month intervals; Fischer's exact test was used to determine if there was a relationship between the grouping (compliant or noncompliant) and tumor recurrence.ResultsMammography yield was 0.94 and 2.87 per 1,000 for the first and second years, respectively, following surgery. Three hundred twenty‐eight patients were categorized as compliant and 1 local recurrence was discovered in this group; 67 patients were labeled as noncompliant and 0 local recurrences were found in this group.ConclusionsMammography yield of cancer in the study population was not greater than the general population. There was no difference between the compliant and noncompliant groups regarding tumor recurrence. J. Surg. Oncol. 2013;107:597–601. © 2012 Wiley Periodicals, Inc.
Pointwise multipliers of Calderón‐Lozanovskiǐ spaces
Authors: Kolwicz Paweł , Leśnik Karol , Maligranda Lech 
Published: December 2012

AbstractSeveral results concerning multipliers of symmetric Banach function spaces are presented firstly. Then the results on multipliers of Calderón‐Lozanovskiǐ spaces are proved. We investigate assumptions on a Banach ideal space E and three Young functions φ1, φ2 and φ, generating the corresponding Calderón‐Lozanovskiǐ spaces \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$E_{\varphi _1}, E_{\varphi _2}, E_{\varphi }$\end{document} so that the space of multipliers \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$M(E_{\varphi _1}, E_{\varphi })$\end{document} of all measurable x such that x y ∈ Eφ for any \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$y \in E_{\varphi _1}$\end{document} can be identified with \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$E_{\varphi _2}$\end{document}. Sufficient conditions generalize earlier results by Ando, O'Neil, Zabreǐko‐Rutickiǐ, Maligranda‐Persson and Maligranda‐Nakai. There are also necessary conditions on functions for the embedding \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$M(E_{\varphi _1}, E_{\varphi }) \subset E_{\varphi _2}$\end{document} to be true, which already in the case when E = L1, that is, for Orlicz spaces \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$M(L^{\varphi _1}, L^{\varphi }) \subset L^{\varphi _2}$\end{document} give a solution of a problem raised in the book 26. Some properties of a generalized complementary operation on Young functions, defined by Ando, are investigated in order to show how to construct the function φ2 such that \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$M(E_{\varphi _1}, E_{\varphi }) = E_{\varphi _2}$\end{document}. There are also several examples of independent interest.
Conformal solitons to the mean curvature flow and minimal submanifolds
Authors: Arezzo C. , Sun J. 
Published: December 2012

AbstractIn this note we prove a correspondence, first found by Smoczyk in the hypersurface case, between conformal solitons to the mean curvature flow in an ambient manifold N and minimal submanifolds in a different space \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$N\times \textbf {R}$\end{document}. This naturally leads to a new natural stability notion for conformal solitons. We show that this corresponds to the recent Colding‐Minicozzi's F‐stability for codimension one self‐shrinkers in euclidean space. In this spirit we can give some classification results for stable conformal solitons, answering two questions of Smoczyk.
Red wine consumption may affect sperm biology: The effects of different concentrations of the phytoestrogen Myricetin on human male gamete function
Authors: Aquila Saveria , Santoro Marta , De Amicis Francesca , Guido Carmela , Bonofiglio Daniela , Lanzino Marilena , Cesario Maria Grazia , Perrotta Ida , Sisci Diego , Morelli Catia 
Published: December 2012

AbstractMyricetin is a natural flavonoid, particularly enriched in red wines, whose occurrence is widespread among plants. Despite extensive research, the beneficial effects of Myricetin on human health are still controversial. Here, we tested the estrogen‐like effect of the phytoestrogen Myricetin on human ejaculated sperm biology. To this aim, human normozoospermic samples were exposed to increasing concentrations (10 nM, 100 nM, and 1 µM) of Myricetin. Motility, viability, capacitation‐associated biochemical changes (i.e., cholesterol efflux and tyrosine phosphorylation), acrosin activity, as well as glucose utilization and fatty‐acid oxidation (i.e., glucose and lipid metabolism) were all significantly increased by low doses of Myricetin. Importantly, both estrogen receptors α and β (ERs) and phosphatidylinositol‐3‐OH kinase (PI3K)/AKT signaling are activated in the presence of Myricetin since these were both abrogated by specific inhibitors of each pathway. Our results show how Myricetin, through ERs and PI3K/AKT signalings, potentiates sperm function. This effect is dose‐dependent at low concentrations of Myricetin (up to 100 nM), whereas higher amounts do not seem to improve any further sperm motility, viability, or other tested features, and, in some cases, they reduced or even abrogated the efficacy exerted by lower doses. Further studies are needed to elucidate if high levels of Myricetin, which could be attained even with moderate wine consumption, could synergize with endogenous estrogens in the female reproductive tract, interfering with the physiological sperm fertilization process. Mol. Reprod. Dev. © 2012 Wiley Periodicals, Inc.
R1 and R2* changes in the human placenta in response to maternal oxygen challenge
Authors: Huen Isaac , Morris David M. , Wright Caroline , Parker Geoff J. M. , Sibley Colin P. , Johnstone Edward D. , Naish Josephine H. 
Published: December 2012

PurposePregnancy complications such as preeclampsia and fetal growth restriction are sometimes thought to be caused by placental abnormalities associated with reduced oxygenation. Oxygen‐enhanced MRI (R1 contrast) and BOLD MRI (R2* contrast) have the potential to noninvasively investigate this oxygen environment at a range of gestational ages.MethodsScanning was carried out at 1.5 T under maternal air and oxygen breathing in a single placental slice in 14 healthy pregnant subjects of gestational ages 21–37 weeks. We report R1 changes using a respiratory‐triggered inversion recovery‐turbo spin‐echo sequence, which is sensitive to changes in PO2, and R2* changes using a breathhold multiple gradient‐recalled echo sequence sensitive to changes in oxygen saturation.ResultsSignificant R1 increases (P < 0.005, paired t‐test) and R2* decreases (P < 0.0001, paired t‐test) between air and oxygen breathing were demonstrated. ΔR1 decreased with gestational age (P < 0.0005, r = −0.835, Pearson correlation test). No significant effect of gestational age on R2* change was observed.ConclusionThe results demonstrate the feasibility of non‐invasive investigation of placental oxygenation using MRI and the sensitivity of R1 oxygen‐enhanced MRI to gestational age. The techniques have the potential to provide unique noninvasive biomarkers in compromised pregnancies. Magn Reson Med 70:1427–1433, 2013. © 2012 Wiley Periodicals, Inc.
High‐frequency subband compressed sensing MRI using quadruplet sampling
Authors: Sung Kyunghyun , Hargreaves Brian A. 
Published: December 2012

PurposeTo present and validate a new method that formalizes a direct link between k‐space and wavelet domains to apply separate undersampling and reconstruction for high‐ and low‐spatial‐frequency k‐space data.Theory and MethodsHigh‐ and low‐spatial‐frequency regions are defined in k‐space based on the separation of wavelet subbands, and the conventional compressed sensing problem is transformed into one of localized k‐space estimation. To better exploit wavelet‐domain sparsity, compressed sensing can be used for high‐spatial‐frequency regions, whereas parallel imaging can be used for low‐spatial‐frequency regions. Fourier undersampling is also customized to better accommodate each reconstruction method: random undersampling for compressed sensing and regular undersampling for parallel imaging.ResultsExamples using the proposed method demonstrate successful reconstruction of both low‐spatial‐frequency content and fine structures in high‐resolution three‐dimensional breast imaging with a net acceleration of 11–12.ConclusionThe proposed method improves the reconstruction accuracy of high‐spatial‐frequency signal content and avoids incoherent artifacts in low‐spatial‐frequency regions. This new formulation also reduces the reconstruction time due to the smaller problem size. Magn Reson Med 70:1306–1318, 2013. © 2012 Wiley Periodicals, Inc.
Partial volume correction in arterial spin labeling using a Look‐Locker sequence
Authors: Petr Jan , Schramm Georg , Hofheinz Frank , Langner Jens , van den Hoff Jörg 
Published: December 2012

PurposePartial volume (PV) effects are caused by limited spatial resolution and significantly affect cerebral blood flow investigations with arterial spin labeling. Therefore, accurate PV correction (PVC) procedures are required. PVC is commonly based on PV maps obtained from segmented high‐resolution T1‐weighted images. Segmentation of these images is error‐prone, and it can be difficult to coregister these images accurately with the single‐shot ASL images such as those created by echo‐planar imaging (EPI). In this paper, an alternative method for PV map generation is proposed.MethodsThe Look‐Locker EPI (LL‐EPI) acquisition is used for analyzing the T1‐recovery curve and for subsequent PV map generation. The new method was evaluated in five healthy volunteers (mean age 30 ± 3.7 years).ResultsBy applying a linear regression method for PVC, a 12% decrease in regression error was reached with the new method.ConclusionPV maps extraction from LL‐EPI is a viable, possibly superior alternative to the standard approach based on segmentation of high‐resolution T1‐weighted images. Magn Reson Med 70:1535–1543, 2013. © 2012 Wiley Periodicals, Inc.
Multilevel computations of dispersed drug release
Authors: Zhao Wei , Pelinovsky Dmitry E. 
Published: December 2012

AbstractWe study a mathematical model of drug release from controlled delivery systems with initial drug loading higher than solubility. The model combines dissolution, diffusion, swelling, and erosion mechanisms of drug delivery. Multilevel methods are introduced to solve the governing system of diffusion equations numerically with better accuracy and lower computational costs compared with the finite element methods. Numerical examples are given to demonstrate the advantages of the multilevel methods. Numerical solutions are compared to exact and approximate solutions of the reduced models. © 2012 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2013
Dually responsive multinetworked hydrogels with improved performances by covalently bonding poly(N‐isopropylacrylamide)‐based microgels and poly(vinyl alcohol) skeleton
Authors: Ma Xiaomei , Li Yanhong , Wang Wenchao , Ji Quan , Xia Yanzhi , Mu Hengxing 
Published: December 2012

AbstractTo prepare intelligent hydrogels with both good mechanical performance and fast response, a series of multinetworked composite hydrogels with pH and thermo‐responsivity were designed and fabricated combining the advantages of both interpenetrating polymer network hydrogels and microgels. To begin with, precipitation polymerization of N‐isopropylacrylamide, methacrylic acid and polyethyleneglycol methacrylate was carried out in poly(vinyl alcohol) (PVA) aqueous solution, yielding thermo‐ and pH‐responsive copolymeric microgels. Then glutaraldehyde was added to the obtained microgel dispersion to covalently bond the microgel particles and PVA through acetal reaction, leading to the formation of multinetworked hydrogels with dual responses. The morphology of microgels and the internal microstructure of composite hydrogels were characterized by transmission electron microscope and scanning electron microscope, respectively. The influence of the PVA content and glutaraldehyde dosage on the mechanical behavior of the prepared hydrogels was investigated by means of uniaxial compressive tests. Experimental results reveal that the as‐prepared composite hydrogels exhibit enhanced mechanical performance compared to conventional hydrogels. Investigation onthe swelling and deswelling behaviors shows that they possess good temperature‐ and pH‐sensitivity andswell/deswell more rapidly than conventional hydrogels. POLYM. COMPOS., 2012. © 2013 Society of Plastics Engineers
Effect of filler size on thermophysical and electrical behavior of nanocomposites based on expanded graphite nanoparticles filled in low‐density polyethylene matrix
Authors: Kratochvíla Ján , Boudenne Abderrahim , Krupa Igor 
Published: December 2012

AbstractVarious aspects of electrical and thermophysical properties of nanocomposites based on low‐density polyethylene matrix filled with nanostructuralized expanded graphite (EG) and standard, microsized graphite are presented in this article. A periodical method developed in the laboratory was used to measure simultaneously thermal conductivity, specific heat, and diffusivity of composites at room temperature. The effect of micro‐ and nanosized fillers on the final thermophysical and electrical behavior is investigated. It was found that the electrical conductivity of composites strongly depends not only on the filler content but also on the filler size. When the microsized graphite was used, the percolation concentration of the filler was found to be 15 vol%, whereas the percolation concentration of the filler in nanocomposites filled with EG of large sizes was significantly lower. Similarly, it was shown that the graphite significantly improves the thermophysical behavior of composites filled with micro‐ and nanofiller sizes. The thermal conductivity measured values were also compared with some theoretical models for the prediction of the thermal conductivity. POLYM. COMPOS., 2012. © 2013 Society of Plastics Engineers
Examining post‐translational modification‐mediated protein–protein interactions using a chemical proteomics approach
Authors: Li Xiang , Foley Emily A. , Kawashima Shigehiro A. , Molloy Kelly R. , Li Yinyin , Chait Brian T. , Kapoor Tarun M. 
Published: December 2012

AbstractPost‐translational modifications (PTM) of proteins can control complex and dynamic cellular processes via regulating interactions between key proteins. To understand these regulatory mechanisms, it is critical that we can profile the PTM‐dependent protein–protein interactions. However, identifying these interactions can be very difficult using available approaches, as PTMs can be dynamic and often mediate relatively weak protein–protein interactions. We have recently developed CLASPI (cross‐linking‐assisted and stable isotope labeling in cell culture‐based protein identification), a chemical proteomics approach to examine protein–protein interactions mediated by methylation in human cell lysates. Here, we report three extensions of the CLASPI approach. First, we show that CLASPI can be used to analyze methylation‐dependent protein–protein interactions in lysates of fission yeast, a genetically tractable model organism. For these studies, we examined trimethylated histone H3 lysine‐9 (H3K9Me3)‐dependent protein–protein interactions. Second, we demonstrate that CLASPI can be used to examine phosphorylation‐dependent protein–protein interactions. In particular, we profile proteins recognizing phosphorylated histone H3 threonine‐3 (H3T3‐Phos), a mitotic histone “mark” appearing exclusively during cell division. Our approach identified survivin, the only known H3T3‐Phos‐binding protein, as well as other proteins, such as MCAK and KIF2A, that are likely to be involved in weak but selective interactions with this histone phosphorylation “mark”. Finally, we demonstrate that the CLASPI approach can be used to study the interplay between histone H3T3‐Phos and trimethylation on the adjacent residue lysine 4 (H3K4Me3). Together, our findings indicate the CLASPI approach can be broadly applied to profile protein–protein interactions mediated by PTMs.