bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of initiation of targeted therapy on the use of psoriatic arthritis-related treatments and healthcare consumption: a cohort study of 9793 patients from the French health insurance database (SNDS)
Authors: Pina Vegas Laura , Iggui Siham , Sbidian Emilie , Claudepierre Pascal 
Published: August 2024

ObjectivesTo assess the potential impact of targeted therapies for psoriatic arthritis (PsA) on symptomatic treatments (non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, opioid analgesics), methotrexate and mood disorder treatments and on hospitalisation and sick leave.MethodsUsing the French health insurance database, this nationwide cohort study included adults with PsA who were new users (not in the year before the index date) of targeted therapies for ≥9 months during 2015–2021. Main endpoints were difference in proportion of users of associated treatments, hospitalisations and sick leaves between 3 and 9 months after and 6 months before targeted therapy initiation. Logistic regression models adjusted for sex, age, psoriasis, inflammatory bowel disease and Charlson Comorbidity Index compared the impact of biologics initiation (tumour necrosis factor inhibitor (TNFi)/interleukin 17 inhibitor (IL17i)/IL12/23i) on associated treatment discontinuation.ResultsAmong 9793 patients initiating targeted therapy for PsA (mean age: 51±13 years, 47% men), 62% initiated TNFi, 14% IL17i, 10% IL12/23i, 1% Janus kinase inhibitor, 12% phosphodiesterase-4 inhibitor. After treatment initiation, the proportion of treatment users was significantly reduced for NSAIDs (−15%), opioid analgesics (−9%), prednisone (−9%), methotrexate (−15%) and mood disorder treatments (−2%), along with decreased hospitalisations (−12%) and sick leaves (−4%). TNFi had a greater sparing effect on NSAIDs and prednisone use than IL17i (ORa=1.04, 95% CI=1.01 to 1.07; 1.04, 1.02 to 1.06) and IL12/23i (1.07, 1.04 to 1.10; 1.06, 1.04 to 1.09). Odds of methotrexate discontinuation was reduced with TNFi versus IL17i (0.96, 0.94 to 0.98) and IL12/23i (0.94, 0.92 to 0.97).ConclusionsTargeted therapy initiation for PsA reduced the use of associated treatment and healthcare, with TNFi having a slightly greater effect than IL17i and IL12/23i, except for methotrexate discontinuation.
Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts
Authors: Sand Jannie Marie Bülow , Jessen Henrik , Leeming Diana Julie , Yu Sheeline , Lee Chris J , Hu Buqu , Sun Ying , Adams Taylor , Pivarnik Taylor , Liu Angela , Woo Samuel , McGovern John R , Fiorini Vitória , Saber Tina , Higuero-Sevilla Jean Paul , Gulati Mridu , Kaminski Naftali , Damsky William , Shaw Albert C , Mohanty Subhasis , Goobie Gillian , Zhang Yingze , Herzog Erica Lyndrup , Ryu Changwan 
Published: August 2024

IntroductionThe pathogenesis of sarcoidosis involves tissue remodelling mediated by the accumulation of abnormal extracellular matrix, which is partly the result of an imbalance in collagen synthesis, cross-linking and degradation. During this process, collagen fragments or neoepitopes, are released into the circulation. The significance of these circulating collagen neoepitopes in sarcoidosis remains unknown.MethodsWe employed plasma samples from patients with sarcoidosis enrolled in A Case Control Etiologic Study of Sarcoidosis (ACCESS) and Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS), and healthy control patients recruited from the Yale community. Plasma concentrations of type III and VI collagen degradation (C3M and C6M) and formation (PRO-C3 and PRO-C6) were quantified via neoepitope-specific competitive ELISA, and statistical associations were sought with clinical phenotypes.ResultsRelative to healthy controls, the plasma of both sarcoidosis cohorts was enriched for C3M and C6M, irrespective of corticosteroid use and disease duration. While circulating collagen neoepitopes were independent of Scadding stage, there was a significant association between multiorgan disease and PRO-C3, PRO-C6 and C3M in the ACCESS cohort; PRO-C3 and C6M displayed this property in GRADS. These findings were unrelated to plasma levels of interleukin-4 (IL-4), IL-5, IL-6, IL-9, IL-10 and IL-13. Moreover, PRO-C3 was associated with dermatological disease in both cohorts.DiscussionIn two well-characterised sarcoidosis cohorts, we discovered that the plasma is enriched for neoepitopes of collagen degradation (C3M and C6M). In multiorgan disease, there was an association with circulating neoepitopes of type III formation (PRO-C3), perhaps mediated by dermatological sarcoidosis. Further investigation in this arena has the potential to foster new insights into the pathogenic mechanisms of this complex disease.
Crustal melting recorded by dykes along the gold-bearing Melanson Brook Fault, northern New Brunswick Appalachians
Authors: Bustard Aaron L. , Lentz David R. , Walker James A. , McFarlane Christopher R.M. 
Published: August 2024

Dykes intruding along the Melanson Brook Fault record two magmatic episodes in northern New Brunswick. Dykes at the South Gold Zone of the Elmtree gold deposit are aphanitic and magnesian–calcic, whereas those at Ellis Brook (2.5 km to the west) are ilmenite-series and weakly peraluminous with hornblende– and plagioclase–porphyritic phases. Elevated 147Sm/144Nd generated by partial melting, titanium depletion, absence of rare earth element fractionation, and trondhjemite-like compositions indicate that the South Gold Zone dykes were sourced from low-volume fluid-fluxed melting of gabbroic crust. An Sm–Nd-depleted model mantle age of 1.1 Ga for the Ellis Brook dykes suggests that they were sourced from melting of Ganderian crustal rocks rather than the sinking Acadian slab. 143Nd/144Nd evolution curves for the South Gold Zone dykes intersect that of the Ellis Brook dykes at 432 and 427 Ma. This suggests that the magma from which the South Gold Zone dykes crystallized was extracted from a similar source area as the magma that generated the Ellis Brook dykes. Evidence of fluid exsolution in the Ellis Brook dykes indicates that they could be a potential source for reduced intrusion-related gold mineralization. The Ellis Brook dykes yielded a U–Pb zircon age of 391 ± 5 Ma, which is consistent with the timing of oceanic slab break-off at the end of the Acadian orogenic cycle. Extraction of South Gold Zone magma occurred up to 40 Myr earlier, likely during the Salinic orogenic cycle.
Lettuce seed pelleting with Pseudomonas sp. 31-12: plant growth promotion under laboratory and greenhouse conditions
Authors: Kangsopa Jakkrapong , Hynes Russell K. , Siri Boonmee 
Published: August 2024

Plant growth promotion by Pseudomonas sp. 31-12 incorporated into a lettuce seed pelleting matrix was studied. We examined (1) the effect of five rhizosphere derived bacterial strains on green oak lettuce ( Lactuca sativa L.) seed germination, root and shoot growth, as a strain selection step for seed coating and seed pelletizing studies, (2) population stability of Pseudomonas sp. 31-12 incorporated into a pelleting matrix on lettuce seed stored three months at 4 °C, and (3) lettuce growth promotion in the laboratory and greenhouse by Pseudomonas sp. 31-12 coated and pelletized seed. A spontaneous streptomycin mutant of Pseudomonas sp. 31-12 (str) was used to determine population size on seed and roots of 15- and 30-day-old lettuce. The population of Pseudomonas sp. 31-12str on coated and pelleted seed decreased from 104 cfu/seed to 103 cfu/seed after 3 months storage at 4 °C. However, the population exceeded 104 cfu/g root dry mass and 105/g root dry mass after 15 days and 30 days in the greenhouse. Leaf fresh mass was significantly increased ( P ≤ 0.05) with Pseudomonas sp. 31-12 seed treatment as compared to noninoculated seed. In conclusion, pelletized lettuce seed with Pseudomonas sp. 31-12 promoted growth and yield in the greenhouse.
New procedure for evaluation of U(3) coupling and recoupling coefficients
Authors: Dang Phong , Draayer Jerry P. , Pan Feng , Becker Kevin S. 
Published: August 2024

AbstractA simple method to calculate Wigner coupling coefficients and Racah recoupling coefficients for U(3) in two group–subgroup chains is presented. While the canonical $$\rm U(3)\supset U(2)\supset U(1)$$

U
(
3
)
⊃
U
(
2
)
⊃
U
(
1
)

coupling and recoupling coefficients are applicable to any system that respects U(3) symmetry, the $$\rm U(3) \supset SO(3)$$

U
(
3
)
⊃
SO
(
3
)

coupling coefficients are more specific to nuclear structure studies. This new procedure precludes the use of binomial coefficients and alternating sums which were used in the 1973 formulation of Draayer and Akiyama, and in so doing provides a faster and more accurate determination of any and all required results. The resolution of the outer multiplicity is based on the null space concept of the U(3) generators proposed by Alex et al., whereas the inner multiplicity in the angular momentum subgroup chain is obtained from the dimension of the null space of the SO(3) raising operator. It is anticipated that a C++ library will ultimately be available for determining generic coupling and recoupling coefficients associated with both the canonical and the physical group–subgroup chains of U(3).
A criterion for modularity of the subgroup lattice of a finite soluble group
Authors: Liu A-Ming , Wang Sizhe , Safonov Vasily G. , Skiba Alexander N. 
Published: August 2024

Let [Formula: see text] be a finite group and [Formula: see text] the subgroup lattice of [Formula: see text]. A subgroup [Formula: see text] of [Formula: see text] is called: (i) modular in [Formula: see text], if [Formula: see text] is a modular element (in the sense of Kurosh) of the lattice [Formula: see text]; (ii) submodular in [Formula: see text] if [Formula: see text] has a chain of subgroups [Formula: see text], where [Formula: see text] is modular in [Formula: see text] for all [Formula: see text]. If [Formula: see text] is a subgroup of [Formula: see text], then we denote by [Formula: see text] the subgroup of [Formula: see text], generated by all of its subgroups that are modular in [Formula: see text]. We say that a subgroup [Formula: see text] is [Formula: see text]-modular in [Formula: see text] ([Formula: see text]), if for some modular subgroup [Formula: see text] of [Formula: see text], containing [Formula: see text], [Formula: see text] avoids the pair [Formula: see text], i.e. [Formula: see text]. We prove that if [Formula: see text] is a soluble finite group and each of its submodular subgroups is [Formula: see text]-modular in [Formula: see text], where [Formula: see text] is the nilpotent residual of [Formula: see text], then the lattice [Formula: see text] is modular.
Preparation and Property Optimization of High Capacity O3-type NaNi0.4Fe0.2Mn0.4O2
Authors: Li Xiaoning , Liu Mengmeng , Zhang Wenjuan , Zhang Yanli , Zhou Jiakun , Zhou Wenzhang , Wang Naixin , Xu Weiwei , Dai Kehua 
Published: August 2024

O3-type NaNi0.4Fe0.2Mn0.4O2 cathode materials are structurally stable and have a high nickel content, allowing for stable high-capacity output. However, their performance needs further improvement. First, we investigated the effects of different sodium contents on the structure, morphology, and electrochemical performance of NaxNi0.4Fe0.2Mn0.4O2(x = 0.85, 0.9, 0.95, 1, 1.05) materials. The Na0.9Ni0.4Fe0.2Mn0.4O2 material exhibited initial discharge specific capacities of 148.11 and 181.80 mAh·g−1 at voltage ranges of 2–4.1 V and 2–4.2 V, respectively. To further optimize the cycling performance of the material, we doped NaNi0.4Fe0.2Mn0.4O2 with different calcium contents. Ca2+ doping significantly enhanced the electrochemical performance of the material. Subsequently, we synthesized Na0.96Ca0.02(NMF)0.95Zn0.05O2, and the dual-doped NMF-Ca0.02Zn0.05 maintains approximately 80% capacity retention at 1–4.05 V, and around 70% as the cut-off voltage increases to 4.15 V in full cells.
Impact of Hypertension on the Dose-Response Association Between Physical Activity and Stroke: A Cohort Study
Authors: McLellan Hannah L. , Dawson Ellen A. , Eijsvogels Thijs M.H. , Thijssen Dick H.J. , Bakker Esmée A. 
Published: August 2024

BACKGROUND:
Regular physical activity is associated with a reduced stroke risk. However, this relationship might be attenuated in the presence of hypertension and antihypertensive medication use. We examined the dose-response relationship between physical activity and stroke in normotensive and hypertensive individuals.

METHODS:
A Dutch population-based cohort including 139 930 individuals (41% men; mean age, 44±13) was performed (median follow-up, 6.75 years). Participants were stratified at baseline as hypertensive (44%) or normotensive (56%) and categorized into quartiles of the lowest (Q1) to the highest (Q4) moderate-to-vigorous, self-reported physical activity. The primary outcome was incident stroke (fatal and nonfatal). Cox regression estimated hazard ratios and 95% CIs. The main analyses were stratified on baseline blood pressure and adjusted for confounders. Hypertensives were stratified into medicated (21%) or non-medicated (79%).

RESULTS:

Compared with Q1, adjusted hazard ratios were 0.87 (0.69–1.10;
P
=0.23), 0.75 (0.59–0.95;
P
=0.02), and 0.94 (0.74–1.20;
P
=0.64) for Q2 to Q4, respectively in the total population. Hazard ratios for normotensives were 0.79 (0.50–1.25;
P
=0.32), 0.75 (0.48–1.18;
P
=0.22), 0.97 (0.62–1.51;
P
=0.90) for Q2 to Q4, respectively. In hypertensives, hazard ratios were 0.89 (0.68–1.17;
P
=0.41), 0.74 (0.56–0.98;
P
=0.03), 0.92 (0.69–1.23;
P
=0.56) for Q2 to Q4, respectively. There was no significant interaction between hypertension status for the relation between physical activity and stroke risk. The stratified analysis revealed a smaller benefit of moderate-to-vigorous physical activity in medicated hypertensives compared with nonmedicated hypertensives, but no significant interaction effect was found.

CONCLUSIONS:
Regular moderate-to-vigorous physical activity is beneficial for stroke risk reduction (Q3 compared with Q1), which is not affected by hypertension. Antihypertensive medication may be associated with a smaller benefit of moderate-to-vigorous physical activity on the risk of stroke, but further research is warranted.
Idiosyncratic long call-like vocalisations in two zoo-housed Bornean orang-utan females
Authors: Roth Tom S. , von Wulffen Clemens , Fox Megan , Askew James , Spierings Michelle , Perea-Garcia Juan Olvido 
Published: August 2024

Abstract
Orang-utans are well-known for their vocal flexibility. However, the described vocal repertoire of female orang-utans is relatively limited. This anecdotal report discusses the occurrence of long call-like vocalisations in two zoo-housed Bornean orang-utan females. While Temmy demonstrated these vocalisations in response to playbacks of male long calls, Eloise proactively produced vocalisations during her ovulation before her reproductive senescence. The vocalisations produced by Temmy and Eloise seem to differ in many aspects from known orang-utan calls, although they bear some similarities to male long calls. Thus, the vocal repertoire of female orang-utans may be more extensive than previously thought. We carefully suggest that these calls might indicate proceptivity, while also discussing methodological limitations and theoretical considerations.
Redescription of two species of the genus Tricirronema Siddiqi, 1993 (Rhabditida, Bicirronematidae) from Vietnam, including SEM study for both species
Authors: Abolafia Joaquín , Ruiz-Cuenca Alba N. , Nguyen Thi Anh Duong 
Published: August 2024

Summary
Two species of the genus Tricirronema: T. tamdaoense and T. tentaculatum, are studied from agricultural soils of Vietnam. Both species are morphologically and morphometrically characterised based on LM and SEM studies. These species are mainly differentiated by the morphology of the vagina, sigmoid in T. tamdaoense and straight in T. tentaculatum, and males with more robust spicules in T. tamdaoense. SEM studies of both species are provided. Molecular analysis based on 18S and 28S rDNA fragments is included for T. tentaculatum, showing relationship with members of the genus Eucephalobus. In addition, a key to species identification of the genus Tricirronema is included, as well as illustrations and a compendium table with the main measurements of the three species.
6. Bartleby
Authors: Tumino Stephen 
Published: August 2024

Chapter Six ("Bartleby"): Melville's "Bartleby, the Scrivener: A Tale of Wall St." has become a signpost in cultural theory for a "new" politics of a "new" capitalism without borders in which wealth and inequality are assumed to acquire "materiality" in the circuits of exchange and thus invalidate the classical Marxist critique. Whether understood in terms of a "refusal of work" (Negri), or as signifying a "new" form of praxis of a "coming community" (e.g., Žižek, Agamben), contemporary readings of "Bartleby" serve as a lexicon in which capitalism is represented as having outlived its basic contradiction inscribed in wage-labor/capital relations and therefore the best mode of "resistance" to capitalism is the "interrupting" of the flows of exchange value. Against what I argue are such accommodationist views— accomodationist in the sense that they all, no matter their surface differences, argue that the time for revolutionary change is over and thus accommodate the domination of finance capital—in this chapter I give an original reading of "Bartleby," along with some exemplary instances of its cyber-left readers, as providing an ideology of capitalism that limits resistance to the realm of circulation and instead will argue for the new not as cultural change in the terms of exploitation but the new as abolishing exploitation.
Keywords: Melville; Bartleby, cyber-capitalism; Žižek; Negri; Agamben.
9. Twin Peaks
Authors: Tumino Stephen 
Published: August 2024

Chapter Nine ("Twin Peaks"): In this chapter I address the question why Twin Peaks was "happening again" in 2017 after twenty-five years. To do so I read it against the socioeconomic and ideological background of the last quarter century.
The original series first aired during the early years of the neoliberal period of global capitalism heralded by neoconservative and Reagan administration functionary Francis Fukuyama as the "end of history." What that meant in neoliberal sociology was the superiority of "free markets" over the ideological driven politics of the past. In cultural theory, class was no longer taken to be the operative division in society on the view that in the "knowledge economy" all have equal access to "cultural capital." Twin Peaks reflected its time. It presented the vision of a world in which material conflicts are resignified as cultural differences and inverts causal explanations into the undecidable play of endless interpretations.
In line with the contemporary historical moment Twin Peaks: The Return presents a much darker vision of the world. If in its original iteration Twin Peaks presented the dark forces of the Black Lodge threatening to engulf the heartland of small town American values, today it depicts a world where the Black Lodge has most decisively triumphed and the show now shows the rapacious spirit of BOB to be a technologically wired and borderless power (moving from Las Vegas to Los Angeles, South Dakota to Buenos Aries), served by a reserve army of unemployed, that New York City billionaires are seeking to harness through science (with the Glass Box device).
Beyond the surface difference of a shift from postmodern cultural politics to a new "materialist" populist politics, what has not fundamentally changed in Twin Peaks: The Return is the basic way that the show performs the ideological function of occulting the class relations that alone explain the state of the world by projecting the cause onto demonic "others"—a secret cabal of evildoers now represented by the "swarthy" doppelgänger of Cooper himself.
Keywords: Twin Peaks; David Lynch; Fukuyama; cultural theory; ideology.
Development of an Advance Research WRF-Based Operational Forecast System for Forcing Ocean Models and Evaluation of Its Winds Using Buoys in the Indian Ocean
Authors: Modi Anuradha , Harikumar R. , Nair T. M. Balakrishnan 
Published: August 2024

Abstract
This paper presents the development of a high-resolution mesoscale atmospheric numerical model Advanced Research version of WRF (ARW 3.7, henceforth ARW)-based operational forecast system and evaluation of its surface wind forecasts using buoys and satellite data in the Indian Ocean. This was set up as part of the ocean-state forecasting system to force the operational ocean models at the Indian National Centre for Ocean Information Services (INCOIS). Evaluation of winds is carried out by comparing the ARW forecasts with ocean buoys and scatterometer observations during 2016. The analysis is conducted separately with coastal and open ocean buoys, revealing marginally better performance in the open ocean simulations. The comparison of ARW forecasted winds against offshore buoy winds shows mean differences for wind speed and direction of −0.1 m s−1 and −3.3°, with root-mean-square errors (RMSEs) of 2.1 m s−1 and 39.0° and correlations of 0.75 and 0.42, respectively. At coastal regimes, the mean differences for wind speed and direction are 0.6 m s−1 and 2.6°, with RMSEs of 2.2 m s−1 and 57° and correlations of 0.63 and 0.60, respectively. The ARW model performs reasonably well compared to the National Centre for Medium-Range Weather Forecasting (NCMRWF) model in capturing wind speed variability in the Arabian Sea compared to the Bay of Bengal. Particularly during the Very Severe Cyclonic Storm (VSCS) Vardah, the ARW model provided more accurate forecasts (high skill score 80%–90%) compared to the NCMRWF model. These results indicate the efficacy of the WRF-based forecast system in predicting surface wind fields in the Indian Ocean region, particularly in the coastal areas, thus endorsing its use for an effective operational ocean forecasting at INCOIS.
Postoperative outcomes and trends in computer-navigated and robotic-assisted total hip arthroplasty
Authors: Piple Amit S , Wang Jennifer C , Hill William , Chen Matthew S , Gettleman Brandon S , Liu Kevin C , Heckmann Nathanael D , Christ Alexander B 
Published: August 2024

Introduction: As the volume of technology-assisted total hip arthroplasty (THA) increases, there is a need to characterise the outcomes of robotic-assisted (RA) and computer-navigated (CN) THA. The goal of this study was to assess outcomes and opioid consumption following CN-THA and RA-THA compared to conventionally-instrumented (CON) THA. Methods: The Premier Database was queried for all patients who underwent primary, elective THA from 2015-2020. Patients were divided into 3 groups: CN, RA, or CON-THA. Yearly usage trends were assessed. Univariate and multivariate analyses were performed to assess the 90-day risk of postoperative complications. Opioid consumption was reported in morphine milligram equivalents (MME) for postoperative days (POD) 0 and 1. Results: Overall, 474,707 elective THAs were identified (95.7% CON, 2.1% CN, 2.2% RA. After accounting for confounders, CN-THA patients were at decreased risk for periprosthetic joint infection (PJI) (aOR: 0.55, p < 0.001) and dislocation (aOR 0.45, p < 0.001), but increased risk for blood transfusion (aOR 1.97, <0.001) compared to CON-THA. RA-THA patients were at decreased risk of dislocation (aOR:0.66, p < 0.001) but increased risk for transfusion (aOR 1.20, p < 0.001), prosthesis breakage (aOR 3.88, p < 0.001), and periprosthetic fracture (aOR 1.72, p < 0.001). Opioid consumption for CN-THA patients was lower on POD1 and lower for RA-THA patients POD0 and 2 compared to CON-THA. Discussion: CN-THA was associated with reduced rates of PJI and dislocation, but increased rates of blood transfusion while RA-THA was associated with decreased rates of dislocation, but increased rates of blood transfusion, prosthesis complications, and periprosthetic fracture compared to CON-THA. Technology-assisted THA was associated with lower postoperative opioid consumption.