bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and factors associated with the correlation between malnutrition and pain in hemodialysis patients
Authors: Jaber Mohammad M. , Abdalla Mazen A. , Mizher Aya , Hammoudi Heba , Hamed Farah , Sholi Abrar , AbuTaha Adham , Hassan Mohannad , Taha Sari , Koni Amer A. , Shakhshir Muna , Zyoud Sa’ed H. 
Published: June 2024

AbstractMalnutrition and pain are common in patients with chronic kidney disease who undergo hemodialysis. Although both pain and malnutrition are associated with increased morbidity and mortality, few studies have explored the correlation between pain and nutritional status. This study aimed to investigate the factors associated with pain intensity in patients undergoing hemodialysis, focusing on the risk of malnutrition. This was a cross-sectional study conducted at a regional dialysis center in a large tertiary hospital. Convenience sampling was used to recruit adult patients who had undergone hemodialysis for more than three months. An interviewer-administered questionnaire was used to gather sociodemographic and clinical data related to dialysis status, comorbidities, and body mass index (BMI). Pain severity and pain interference with functioning domains of the Brief Pain Index (BPI) were used to assess pain, and the malnutrition inflammation score (MIS) was used to assess nutritional status. Descriptive and inferential statistics were used to report the findings. The data were analyzed using the 25th version of the Statistical Package for the Social Sciences (IBM-SPSS) software. Of the final sample of 230 patients, 63.0% were males and 37.0% were females, with an average age of 58.3 years. Almost one-third of the participants had a BMI within the normal range (33.9%), and nearly one-third had a BMI within the underweight range (33.9%). Slightly more than half had a normal nutritional status or mild malnutrition (54.8%), while just under half had moderate or severe malnutrition (45.2%). The prevalence of pain was 47.0%. At the multivariate level, the severity of pain was associated with malnutrition (p < 0.001). Pain interference with function was associated with marital status (p = 0.045), number of comorbidities (p = 0.012), and malnutrition (p < 0.001). The MIS was positively correlated with both the severity of pain and the interference score. Pain and malnutrition were found to be prevalent in patients undergoing hemodialysis. Pain severity was associated with malnutrition, and pain interference was associated with malnutrition, marital status, and the number of comorbidities. Hemodialysis treatment should follow a patient-tailored approach that addresses pain, nutritional status, and associated chronic conditions. In addition, pain assessment and management should be included in the curriculum of nephrology training programs.
Investigating the genetic determination of duration-of-fertility trait in breeding hens
Authors: Luo Wei , Huang Xishi , Li Jingxuan , Gu Lantao 
Published: June 2024

AbstractThe duration-of-fertility (DF), which was defined as the number of days when breeding hens lay fertile eggs following copulation or artificial insemination (AI), is an important economic trait in chick production when it has strong effects on fertile egg output and production costs. Little is known about the underlying genes and molecular markers related to DF trait to date. Here, we measured the DF of 701 Chinese Jinghong hens and 408 Jingfen hens. The DF showed high individual variability and potential for genetic improvement. Then, 192 Jinghong breeding hens were provided for a genome-wide association study, 27 SNPs respectively located in three genomic linkage regions (GGA1:41Kb; GGA3:39Kb and GGA8:39Kb) were suggested to be significantly associated with DF. Particularly, 6 of these 27 SNPs were further verified to be associated with DF in the 701 Jinghong and 408 Jingfen hens using PCR-RFLP genotyping method. These 27 SNPs were also mapped to 7 genes according to their genomic position. Furtherly, 5 of these 7 genes were tested using qPCR. Results show that the CYP2D6, WBP2NL, ESR1 and TGFBR3 mRNA expression levels of hens with long DF were significantly higher than the hens with short DF (P < 0.05). Overall, findings in our research provide new insight into the genetic basis of duration-of-fertility in breeding hens while providing new clues for further functional validation on the DF-related genetic regulation mechanism and improvement of DF through chicken breeding.
Development of data-driven modeling method for nonlinear coupling components
Authors: Ryu Taesan , Baek Seunghun 
Published: June 2024

AbstractThis research introduces a methodology for data-driven regression modeling of components exhibiting nonlinear characteristics, utilizing the sparse identification of nonlinear dynamics (SINDy) method. The SINDy method is extended to formulate regression models for interconnecting components with nonlinear traits, yielding governing equations with physically interpretable solutions. The proposed methodology focuses on extracting a model that balances accuracy and sparsity among various regression models. In this process, a comprehensive model was generated using linear term weights and an error histogram. The applicability of the proposed approach is demonstrated through a case study involving a sponge gasket with nonlinear characteristics. By contrasting the predictive model with experimental responses, the reliability of the methodology is verified. The results highlight that the regression model, based on the proposed technique, can effectively establish an accurate dynamical system model, accounting for realistic conditions.
CT perfusion-guided administration of IV milrinone is associated with a reduction in delayed cerebral infarction after subarachnoid hemorrhage
Authors: Szabo Vivien , Baccialone Sarah , Kucharczak Florentin , Dargazanli Cyril , Garnier Oceane , Pavillard Frederique , Molinari Nicolas , Costalat Vincent , Perrigault Pierre-Francois , Chalard Kevin 
Published: June 2024

AbstractDelayed cerebral ischemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH) is a singular pathological entity necessitating early diagnostic approaches and both prophylactic and curative interventions. This retrospective before-after study investigates the effects of a management strategy integrating perfusion computed tomography (CTP), vigilant clinical monitoring and standardized systemic administration of milrinone on the occurrence of delayed cerebral infarction (DCIn). The $${\text{"before"}}$$
"before"
period included 277 patients, and the $${\text{"after"}}$$
"after"
one 453. There was a higher prevalence of Modified Fisher score III/IV and more frequent diagnosis of vasospasm in the $${\text{"after"}}$$
"after"
period. Conversely, the occurrence of DCIn was reduced with the $${\text{"after"}}$$
"after"
management strategy (adjusted OR 0.48, 95% CI [0.26; 0.84]). Notably, delayed ischemic neurologic deficits were less prevalent at the time of vasospasm diagnosis (24 vs 11%, $$p=0.001$$

p
=
0.001

), suggesting that CTP facilitated early detection. In patients diagnosed with vasospasm, intravenous milrinone was more frequently administered (80 vs 54%, $$p<0.001$$

p
<
0.001

) and associated with superior hemodynamics. The present study from a large cohort of aSAH patients suggests, for one part, the interest of CTP in early diagnosis of vasospasm and DCI, and for the other the efficacy of CT perfusion-guided systemic administration of milrinone in both preventing and treating DCIn.
Association between maximum norepinephrine dosage and mortality risk in neonates with septic shock
Authors: Zhong Junjuan , Zhang Jing , Lin Yingyi , Ma Dongju , Mo Jing , Ye Xiuzhen 
Published: June 2024

AbstractThe high-dose usage of norepinephrine is thought to cause high mortality in patients with septic shock. This study aims to explores the correlation between the maximum norepinephrine (NE) dosage (MND) and mortality in neonates with septic shock. This retrospective cohort study included neonates with evidence of septic shock and those who received NE infusion. The study included 123 neonates, with 106 in the survival group and 17 in the death group. The death group exhibited significantly lower birth weight (p = 0.022), 1-min Apgar score (p = 0.005), serum albumin (p < 0.001), and base excess (BE) (p = 0.001) levels, but higher lactate (LAC) levels (p = 0.009) compared to the survival group. MND demonstrated an ROC area under the curve of 0.775 (95% CI 0.63–0.92, p < 0.001) for predicting mortality, with an optimal threshold of 0.3 µg/(kg·min), a sensitivity of 82.4%, and a specificity of 75.5%. Multivariate logistic regression indicated that an MND > 0.3 µg/(kg·min) (OR, 12.08, 95% CI 2.28–64.01) was associated with a significantly higher mortality risk. Spearman rank correlation showed a positive correlation between MND and LAC (r = 0.252, p = 0.005), vasoactive-inotropic score (VIS) (r = 0.836, p < 0.001), and a negative correlation with BE (r = − 0.311, p = 0.001). MND > 0.3 µg/(kg min) is a useful predictive marker of mortality in neonatal septic shock.
Simulation analysis of the evolution law of creep rupture crack extension in X-fractured rock body
Authors: Zhao Na , Wei Shuai , Wang Laigui , Sun Jingyi 
Published: June 2024

AbstractCreep is the macroscopic manifestation of the process of generation, expansion, and penetration of microscopic cracks in a rock body. In this study, the GDEM continuous–discontinuous numerical simulation software was used to model a rock body containing X-fractured for the purposes of exploring creep crack expansion and rupture in the rock body, analyzing the effects of various factors on X-fractured the rock body under the rule of change of the creep curve, and assessing the influences of the intersection angle of the fracture and other factors on the non-parallel fractured rock body on the creep rupture process. The results show that an X-fractured rock body exhibits a mixed tensile–shear damage mode, with tensile damage being the main type of damage. In the isotropic creep stage of a rock body with X-fractured , the steady-state creep rate initially increases and then decreases as the sub- fracture length increases, with the change of the fracture angle of the creep rate of the w-type; the sub-fracture length of h is 14 mm, the rock body is the first to enter into the accelerated creep stage, for the different fracture intersection angle of the rock body For the rock mass with different fracture angles, the time sequence of entering the accelerated creep stage is consistent with the creep rate; when the fracture intersection angle is 45°, and the sub-fracture length is 12 mm, the rock mass has the largest degree of fragmentation, which has a significant impact on the creep damage; after using a single variable processing, it is found that the fracture intersection angle, the sub-fracture length and other factors compared to the fracture intersection angle has a greater impact on the creep damage of the X-fractured rock body. This paper can provide theoretical basis and reference for the study of rock engineering creep damage law and mechanical properties of X-fractured rock body.
Novel Alzheimer's disease subtypes based on functional brain connectivity in human connectome project
Authors: Sheng Jinhua , Xin Yu , Zhang Qiao , Yang Ze , Wang Luyun , Zhang Qian , Wang Binbing 
Published: June 2024

AbstractThe pathogenesis of Alzheimer's disease (AD) remains unclear, but revealing individual differences in functional connectivity (FC) may provide insights and improve diagnostic precision. A hierarchical clustering-based autoencoder with functional connectivity was proposed to categorize 82 AD patients from the Alzheimer's Disease Neuroimaging Initiative. Compared to directly performing clustering, using an autoencoder to reduce the dimensionality of the matrix can effectively eliminate noise and redundant information in the data, extract key features, and optimize clustering performance. Subsequently, subtype differences in clinical and graph theoretical metrics were assessed. Results indicate a significant inter-subject heterogeneity in the degree of FC disruption among AD patients. We have identified two neurophysiological subtypes: subtype I exhibits widespread functional impairment across the entire brain, while subtype II shows mild impairment in the Limbic System region. What is worth noting is that we also observed significant differences between subtypes in terms of neurocognitive assessment scores associations with network functionality, and graph theory metrics. Our method can accurately identify different functional disruptions in subtypes of AD, facilitating personalized treatment and early diagnosis, ultimately improving patient outcomes.
Carica papaya L. sex chromosome review and physical mapping of the serk 2, svp-like and mdar 4 sequences
Authors: Dornela Adeilson Frias , Soares Fernanda Aparecida Ferrari , Silva Jéssica Coutinho , Sattler Mariana Cansian , Clarindo Wellington Ronildo 
Published: June 2024

AbstractPhysical mapping evidences the chromosome organization and structure. Despite the data about plant cytogenomics, physical mapping has been conducted from single-copy and/or low-copy genes for few species. Carica papaya cytogenomics has been accomplished from BAC-FISH and repeatome sequences. We aimed to map the serk 2, svp-like and mdar 4 sequences in C. papaya. The sequences were amplified and the amplicons sequenced, showing similarity in relation to serk 2, svp-like and mdar 4 genes. Carica papaya diploidy was confirmed and the mitotic chromosomes characterized. The chromosome 1 exhibited the secondary constriction pericentromeric to the centromere of the long arm. So, we concluded that it is the sex chromosomes. serk 2 was mapped in the long arm interstitial portion of the sex chromosomes, and the interphase nuclei showed two fluorescence signals. Considering these results and the sequencing data from the C. papaya sex chromosomes, svp-like and mdar 4 genes were mapped in the interstitial region of the sex chromosome long arm. Both sequences showed only one fluorescence signal in the interphase nuclei. The procedure adopted here can be reproduced for other single-copy and/or low-copy genes, allowing the construction of cytogenetic maps. In addition, we revisited the cytogenomics data about C. papaya sex chromosomes, presenting a revised point of view about the structure and evolution to these chromosomes.
Effect of concurrent action observation, peripheral nerve stimulation and motor imagery on dexterity in patients after stroke: a pilot study
Authors: Seitz Sarina , Schuster-Amft Corina , Wandel Jasmin , Bonati Leo H. , Parmar Katrin , Gerth Hans Ulrich , Behrendt Frank 
Published: June 2024

AbstractResearch to improve and expand treatment options for motor impairment after stroke remains an important issue in rehabilitation as the reduced ability to move affected limbs is still a limiting factor in the selection of training content for stroke patients. The combination of action observation and peripheral nerve stimulation is a promising method for inducing increased excitability and plasticity in the primary motor cortex of healthy subjects. In addition, as reported in the literature, the use of action observation and motor imagery in conjunction has an advantage over the use of one or the other alone in terms of the activation of motor-related brain regions. The aim of the pilot study was thus to combine these findings into a multimodal approach and to evaluate the potential impact of the concurrent application of the three methods on dexterity in stroke patients. The paradigm developed accordingly was tested with 10 subacute patients, in whom hand dexterity, thumb-index pinch force and thumb tapping speed were measured for a baseline assessment and directly before and after the single intervention. During the 10-min session, patients were instructed to watch a repetitive thumb-index finger tapping movement displayed on a monitor and to imagine the sensations that would arise from physically performing the same motion. They were also repeatedly electrically stimulated at the wrist on the motorically more affected body side and asked to place their hand behind the monitor for the duration of the session to support integration of the displayed hand into their own body schema. The data provide a first indication of a possible immediate effect of a single application of this procedure on the dexterity in patients after stroke.
Changes in bone turnover markers 6–12 months after bariatric surgery
Authors: Farup Per G. 
Published: June 2024

AbstractA rise in bone turnover markers (BTM) after bariatric surgery predicts poor bone health years later. This study explored factors associated with BTM and changes in BTM after bariatric surgery. Inclusion criteria were subjects 18 to 65 years of age with morbid obesity undergoing bariatric surgery. All data were measured before and 6 and 12 months after surgery. The study included 104 subjects: women/men: 83/21; mean age 43.1 (SD 8.4) years; BMI: 38.8 kg/m2 (SD 3.8). Surgery with Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) was performed in 84 (81%) and 20 (19%) subjects, respectively. From before to 6–12 months after surgery, procollagen type 1 N-terminal propeptid (P1NP) increased by 45.6 µg/L (95% CI 41.5–50.0, p < 0.001), and alkaline phosphatase (ALP) by 10 U/L (95% CI 7–14, p < 0.001). The increases were significantly larger after RYGB than after SG. The APOE- Ɛ3 allele was associated with low levels of BTM and high levels of leptin. There was an unfavourable increase in BTM after bariatric surgery. SG compared to RYGB and the presence of the APOE-Ɛ3 allele were associated with less unfavourable effects. The study emphasises the importance of optimal prophylactic interventions after bariatric surgery to prevent osteoporosis.
Insuring woylies (Bettongia penicillata ogilbyi) against extinction: establishment of Perup Sanctuary
Authors: Harrison Natasha D. , Thorn Sian M. , Maxwell Marika A. , Ward Colin G. , Wayne Julia C. , Wayne Adrian F. 
Published: June 2024

Context Predator free havens are increasingly relied upon to preserve populations of imperilled species, yet despite their substantial cost, the success of these ventures is rarely critically evaluated. Aims Based on 12 years of population monitoring data, we report on the translocation of woylies (Bettongia penicillata ogilbyi) to Perup Sanctuary, a 423 ha predator-free haven in the south west of Western Australia. Methods We built spatially explicit capture–recapture models to estimate population density, population growth rates, and survivorship of woylies inside the sanctuary. Using these estimates, and additional demographic information, we aimed to show key drivers of population density, evaluate the establishment of the sanctuary population against predetermined translocation success criteria, and run simulations of different sampling designs to determine a robust sampling design for future monitoring of this population. Key results The population rapidly increased in the first 3 years (2010–2013), and then fluctuated around a density of ~0.9 woylies ha−1 before declining slightly in recent years to ~0.6 woylies ha−1. All translocation success criteria evaluated were met. The previous 3 months’ rainfall was a key driver of population density and body weight declined over time, indicating that the population may be regulated by food resources. Conclusions Woylies have established and persisted in Perup Sanctuary, and against the criteria, the translocation of woylies into Perup sanctuary is a success. Harvests from this population appear to have been sustainable. We discuss these findings in the context of the Perup Sanctuary, and recommend ongoing monitoring continue to ensure that the population remains viable and well managed. Implications We describe important considerations for the supplementation and harvest of fenced populations, including: the source of animals (selecting free-living individuals over captive ones); the timing of release (releasing more individuals early on may improve establishment probabilities); and rates of harvest (<30% of adults harvested per generation seemeded to be sustainable for woylies in this case). The results from this study can inform the ongoing management of this and other havened populations, to ensure they continue to benefit mammal conservation.
380 Creating seamless clean breathing spaces for workers and communities: Impractical dream or a feasible reality?
Authors: Balakrishnan Kalpana 
Published: June 2024

Abstract
Clean breathing spaces are a critical requirement for protection of worker and community health. While workplaces in formal sectors of developed countries are often well regulated, majority of workforce in low and middle income countries (LMICs) is exposed to unhealthy concentrations of particulates, gases and fumes.
Nearly 0.5 million deaths and 11.8 million Disability adjusted life years (DALYs) were attributable to occupational air pollution in 2019, with South Asia experiencing some of the highest burdens. Further, with ninety-five percent of the world’s population lives in areas where the ambient concentrations exceed World Health Organisation (WHO) guidelines, for healthy air, ambient pollution was responsible for over 4 million deaths and 118 million DALYs in 2019. This makes it imperative that air pollution is addressed seamlessly across multiple micro-environments that workers and communities spend their productive years. This places air pollution near or at the top of the list of all known risk factors for ill health globally and especially in LMICs, exceeding risks from high blood pressure, tobacco smoking, child and maternal malnutrition. With competing risk factors and limited resources, the dual burden from occupational and ambient air pollution poses an enormous challenge for air quality management.
The talk will provide an overview of the air pollution exposure and health risk situation with a focus on developing country workers and communities and the special challenges faced by LMICs in prioritizing air quality actions to create “seamless breathing spaces” across occupational and community environments.
1 Implementation of low-cost sensors in open-cut mining: qualitative assessment of workplace exposure to improve emissions management and reduce risk
Authors: Ilic Dusan , Lavrinec Aleksej 
Published: June 2024

Abstract

Introduction
Air quality and workplace exposure are both important considerations in open-cut mining. Regulation typically involves a few expensive reference monitors located at the boundary, assessing hourly and daily concentrations while workplace exposure is assessed once or twice a year. Controlling associated environmental and health risks is typically instigated by subjective operator judgement. Low-cost, portable sensors can supplement these methods to increase both spatial and temporal resolution at a fraction of the cost.

Methodology
Bespoke low-cost autonomous units were built. The units are solar powered with battery backup and can be deployed in minutes. Each unit samples, averages and sends data to a gateway with the data visualised on an online dashboard. More than a dozen sensors were deployed, and particulate matter data collected from different areas of the mine, over a period of four months.

Results
Easy installation and quick sampling rate enabled assessment of instantaneous dust generation, in close vicinity to mining activity. Different areas showed periods of similar but also varying particulate matter concentrations, in some instances more than four times difference when averaged over two weeks and more than ten times when considering short-term, five-minute data.

Conclusions
A real-time system to supplement existing boundary and personal particulate matter monitors is demonstrated to work. The network of sensors can lead to more data-driven decision making with minimised subjectivity and can be integrated into a dust management and action plan that can reduce operational downtime due to regulatory exceedance and occupational risk.