bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Rectangles with Rod‐Shaped Disulfonic Acids
Authors: Zitzer Christina , Muesmann Thomas W. T. , Hunfeld Karina , Christoffers Jens , Wickleder Mathias S. 
Published: March 2015

AbstractPolysulfonic acids and their compounds have been scarcely investigated, despite the huge knowledge that we have of the respective polycarboxylic acids and polycarboxylates. This is because of the limited availability of polysulfonic acids, for which reliable synthetic protocols are often lacking. Here, we present the first compound of the recently reported disulfonic acid 1,4‐bis(4‐sulfophenyl)butadiyne (H2DPBDS) prepared in our groups and a new compound of the commercially available 4,4′‐biphenyldisulfonic acid (H2BPDS). The zinc sulfonates [Zn2(BPDS)2(NMP)6]·2NMP [I, NMP = N‐methylpyrrolidone; triclinic, P$\bar {1}$, Z = 2, a = 972.8(2), b = 981.5(2), c = 1915.2(2) pm, α = 87.73(3)°, β = 77.68(3)°, γ = 89.36(3)°, V = 1785.0(6) Å3] and [Zn2(DPBDS)2(DMA)6]·2DMA [II, DMA = dimethylacetamide; triclinic, P$\bar {1}$, Z = 2, a = 973.79(2), b = 1347.53(2), c = 1411.08(2) pm, α = 110.531(1)°, β = 92.445(1)°, γ = 101.931(1)° V = 1683.11(5) Å3] display rigid molecular rectangles constructed from two zinc atoms and two sulfonate ligands. The rectangles are assembled through weak interactions to form soft host lattices that incorporate the solvent DMA or NMP molecules, partly through Zn2+ coordination. Thermal analysis shows that the solvent molecules can be completely removed without decomposition of the coordination polymers.
Electrochemical Sensing Performances for Uric Acid Detection on Various Amine Adlayers Used in Immobilizing Reduced Graphene Oxide
Authors: Park Sumi , Hwang Shinjae , Takenaka Shigeori , Kim Kyuwon 
Published: March 2015

AbstractWe investigated an influence of amine adlayer on electrochemical sensing performances for uric acid detection on reduced graphene oxide (RGO)‐decorated indium‐tin oxide electrode surfaces. Various amine‐terminated molecules including aminoethyl aryldiazonium cation, 2,2′‐(ethylenedioxy)bis(ethylamine), 3‐aminopropyltriethoxysilane, polyethyleneimine were introduced as adlayers to electrostatically immobilize RGO on the electrode surfaces. The anodic oxidation current of uric acid was observed on the various surfaces with differential pulse voltammetry. The current was highly enhanced by electrocatalytic activity of RGO. The sensing performances including linearity, sensitivity, limit of detection, and correlation coefficient were measured and compared. The adlayer with 3‐aminopropyltriethoxysilane showed the best performances on the RGO‐modified surface.
High‐order implicit Runge–Kutta time integrators for fluid‐structure interactions
Authors: Cori Jean‐François , Etienne Stephane , Garon Andre , Pelletier Dominique 
Published: March 2015

SummaryThis paper presents an approach to develop high‐order, temporally accurate, finite element approximations of fluid‐structure interaction (FSI) problems. The proposed numerical method uses an implicit monolithic formulation in which the same implicit Runge–Kutta (IRK) temporal integrator is used for the incompressible flow, the structural equations undergoing large displacements, and the coupling terms at the fluid‐solid interface. In this context of stiff interaction problems, the fully implicit one‐step approach presented is an original alternative to traditional multistep or explicit one‐step finite element approaches. The numerical scheme takes advantage of an arbitrary Lagrangian–Eulerian formulation of the equations designed to satisfy the geometric conservation law and to guarantee that the high‐order temporal accuracy of the IRK time integrators observed on fixed meshes is preserved on arbitrary Lagrangian–Eulerian deforming meshes. A thorough review of the literature reveals that in most previous works, high‐order time accuracy (higher than second order) is seldom achieved for FSI problems. We present thorough time‐step refinement studies for a rigid oscillating‐airfoil on deforming meshes to confirm the time accuracy on the extracted aerodynamics reactions of IRK time integrators up to fifth order. Efficiency of the proposed approach is then tested on a stiff FSI problem of flow‐induced vibrations of a flexible strip. The time‐step refinement studies indicate the following: stability of the proposed approach is always observed even with large time step and spurious oscillations on the structure are avoided without added damping. While higher order IRK schemes require more memory than classical schemes (implicit Euler), they are faster for a given level of temporal accuracy in two dimensions. Copyright © 2015 John Wiley & Sons, Ltd.
Effective connectivity of brain regions related to visual word recognition: An fMRI study of Chinese reading
Authors: Xu Min , Wang Tianfu , Chen Siping , Fox Peter T. , Tan Li Hai 
Published: March 2015

AbstractPast neuroimaging studies have focused on identifying specialized functional brain systems for processing different components of reading, such as orthography, phonology, and semantics. More recently, a few experiments have been performed to look into the integration and interaction of distributed neural systems for visual word recognition, suggesting that lexical processing in alphabetic languages involves both ventral and dorsal neural pathways originating from the visual cortex. In the present functional magnetic resonance imaging study, we tested the multiple pathways model with Chinese character stimuli and examined how the neural systems interacted in reading Chinese. Using dynamic causal modeling, we demonstrated that visual word recognition in Chinese engages the ventral pathway from the visual cortex to the left ventral occipitotemporal cortex, but not the dorsal pathway from the visual cortex to the left parietal region. The ventral pathway, however, is linked to the superior parietal lobule and the left middle frontal gyrus (MFG) so that a dynamic neural network is formed, with information flowing from the visual cortex to the left ventral occipitotemporal cortex to the parietal lobule and then to the left MFG. The findings suggest that cortical dynamics is constrained by the differences in how visual orthographic symbols in writing systems are linked to spoken language. Hum Brain Mapp 36:2580–2591, 2015. © 2015 Wiley Periodicals, Inc.
Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion‐weighted MRI in head and neck squamous cell carcinomas
Authors: Driessen Juliette P. , van Bemmel Alexander J. M. , van Kempen Pauline M. W. , Janssen Luuk M. , Terhaard Chris H. J. , Pameijer Frank A. , Willems Stefan M. , Stegeman Inge , Grolman Wilko , Philippens Marielle E.P. 
Published: March 2015

AbstractBackgroundIdentification of prognostic patient characteristics in head and neck squamous cell carcinoma (HNSCC) is of great importance. Human papillomavirus (HPV)‐positive HNSCCs have favorable response to (chemo)radiotherapy. Apparent diffusion coefficient, derived from diffusion‐weighted MRI, has also shown to predict treatment response. The purpose of this study was to evaluate the correlation between HPV status and apparent diffusion coefficient.MethodsSeventy‐three patients with histologically proven HNSCC were retrospectively analyzed. Mean pretreatment apparent diffusion coefficient was calculated by delineation of total tumor volume on diffusion‐weighted MRI. HPV status was analyzed and correlated to apparent diffusion coefficient.ResultsSix HNSCCs were HPV‐positive. HPV‐positive HNSCC showed significantly lower apparent diffusion coefficient compared to HPV‐negative. This correlation was independent of other patient characteristics.ConclusionIn HNSCC, positive HPV status correlates with low mean apparent diffusion coefficient. The favorable prognostic value of low pretreatment apparent diffusion coefficient might be partially attributed to patients with a positive HPV status. © 2015 Wiley Periodicals, Inc. Head Neck 38: E613–E618, 2016
Indocyanine green fluorescence mapping of sentinel lymph node in patients with recurrent nasopharyngeal carcinoma after previous radiotherapy
Authors: Chan Jimmy Yu Wai , Tsang Raymond King Yin , Wong Stanley Thian Sze , Wei William Ignace 
Published: March 2015

AbstractBackgroundThe purpose of this study was to present the feasibility of indocyanine green (ICG) mapping of sentinel lymph node in recurrent nasopharyngeal carcinoma (NPC).M1ethodsPeritumoral injection of 5‐mg ICG solution and real‐time mapping of the sentinel lymph nodes in the neck was performed during surgery. The sentinel lymph node identified was excised and sent separately for laboratory analysis. Selective neck dissection was then performed. The number and level of the sentinel lymph nodes, their signal‐to‐background ratio, and the histopathology of the sentinel lymph nodes and the neck dissection specimens were studied.ResultsA total of 5 patients were recruited into this study, of which 9 sentinel lymph nodes were identified. The majority of them were located in level II. The mean detection time after ICG injection was 288 seconds. The sentinel lymph nodes in 3 patients tested positive for malignancy. None of the selective neck dissection specimens harbored microscopic tumor deposits.ConclusionICG mapping of sentinel lymph nodes in locally recurrent NPC is potentially feasible. It offers a better nodal staging in patients with clinically N0 disease status © 2015 Wiley Periodicals, Inc. Head Neck 37: E169–E173, 2015
Recommendations for implant‐retained nasal prostheses after ablative tumor surgery: Minimal surgical aftercare, high implant survival, and satisfied patients
Authors: Korfage Anke , Raghoebar Gerry M. , Noorda Willem D. , Plaat Boudewijn E. , Vissink Arjan , Visser Anita 
Published: March 2015

AbstractBackgroundNasal defects resulting from tumor resection are preferably rehabilitated with implant‐retained nasal prostheses. Aftercare, clinical outcome of the implants, and patients’ satisfaction with implant‐retained nasal prostheses were assessed.MethodsTwenty‐eight consecutive patients needing total rhinectomy because of tumor resection between 1998 and 2013 were treated according to a standardized protocol with 2 implants in the nasal floor. Surgical and prosthetic aftercare was scored using patient records. Finally in 2014, skin reaction, peri‐implant bone loss, and patients’ satisfaction were assessed in all 13 still living patients.ResultsIn total, 56 implants were inserted (median follow‐up, 35.1 months; interquartile range [IQR], 8.9–63.3). Implant survival was 96.4%. Implant survival was independent of radiotherapy. Peri‐implant skin was healthy and patients’ satisfaction high. Longevity of the prostheses was limited.ConclusionRehabilitation of nasal defects resulting from total rhinectomy with implant‐retained nasal prostheses, according to our protocol, resulted in high patient satisfaction and favorable treatment outcome. © 2015 Wiley Periodicals, Inc. Head Neck 38: E–E, 2016
Pharyngocutaneous fistula and delay in free oral feeding after pharyngolaryngectomy for hypopharyngeal cancer
Authors: Suzuki Sayaka , Yasunaga Hideo , Matsui Hiroki , Horiguchi Hiromasa , Fushimi Kiyohide , Yamasoba Tatsuya 
Published: March 2015

AbstractBackgroundRisk factors for pharyngocutaneous fistula and associated delay in free oral feeding after pharyngolaryngectomy for patients with hypopharyngeal cancer remain uncertain.MethodsWe used a Japanese national inpatient database to perform a retrospective cohort study between 2007 and 2013. We performed multivariable logistic regression analysis to identify patient characteristics associated with pharyngocutaneous fistula formation, and Cox regression analysis to evaluate factors affecting the interval from pharyngolaryngectomy to free oral feeding.ResultsAmong 549 eligible patients, 33 had developed pharyngocutaneous fistula, 19 of whom required surgical closure. Preoperative radiotherapy significantly increased risk of pharyngocutaneous fistula (odds ratio [OR] = 3.17; 95% confidence interval [CI] = 1.10–9.12; p = .033). Pharyngocutaneous fistula significantly prolonged the interval to oral feeding (median days, 67 vs 20 in those with and without pharyngocutaneous fistula, respectively; hazard ratio [HR], = 0.26; 95% CI = 0.15–0.44; p < .001).ConclusionPreoperative radiotherapy was associated with increased occurrence of pharyngocutaneous fistula and subsequent delay in free oral feeding. © 2015 Wiley Periodicals, Inc. Head Neck 38: E–E, 2016
Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes
Authors: Felice Francesca , Di Stefano Rossella , Pini Stefano , Mazzotta Gianfranco , Bovenzi Francesco M. , Bertoli Daniele , Abelli Marianna , Borelli Lucia , Cardini Alessandra , Lari Lisa , Gesi Camilla , Michi Paola , Morrone Doralisa , Gnudi Luigi , Balbarini Alberto 
Published: March 2015

ObjectivesCirculating endothelial progenitor cells (EPCs) are related to endothelial function and progression of coronary artery disease. There is evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression. We investigated the relationships between the level of circulating EPCs and depression and anxiety in patients with acute coronary syndrome (ACS).MethodsPatients with ACS admitted to three Cardiology Intensive Care Units were evaluated by the SCID‐I to determine the presence of lifetime and/or current mood and anxiety disorders according to DSM‐IV criteria. The EPCs were defined as CD133+CD34+ KDR+ and evaluated by flow cytometry. All patients underwent standardized cardiological and psychopathological evaluations. Parametric and nonparametric statistical tests were performed where appropriate.ResultsOut of 111 ACS patients, 57 were found to have a DSM‐IV lifetime or current mood or anxiety disorder at the time of the inclusion in the study. The ACS group with mood or anxiety disorders showed a significant decrease in circulating EPC number compared with ACS patients without affective disorders. In addition, EPC levels correlated negatively with severity of depression and anxiety at index ACS episode.ConclusionsThe current study indicates that EPCs circulate in decreased numbers in ACS patients with depression or anxiety and, therefore, contribute to explore new perspectives in the pathophysiology of the association between cardiovascular disorders and affective disorders. Copyright © 2015 John Wiley & Sons, Ltd.
High preoperative levels of serum glypican‐3 containing N‐terminal subunit are associated with poor prognosis in patients with hepatocellular carcinoma after partial hepatectomy
Authors: Haruyama Yukihiro , Yorita Kenji , Yamaguchi Tetsuji , Kitajima Sachiko , Amano Jun , Ohtomo Toshihiko , Ohno Akinobu , Kondo Kazuhiro , Kataoka Hiroaki 
Published: March 2015

Glypican‐3 (GPC3) is a glycosylphosphatidylinositol‐anchored cell surface glycoprotein overexpressed in hepatocellular carcinoma (HCC) cells and may serve as a potential molecular target for therapeutic intervention. This study evaluated the prognostic significance of serum GPC3 in HCC patients receiving curative surgery. A novel sandwich enzyme‐linked immunosorbent assay for the quantitative and sensitive determination of serum GPC3 N‐terminal subunit antigen (sGPC3N) was developed and used to measure sGPC3N levels in 25 healthy volunteers and 115 HCC patients who underwent curative partial hepatectomy. The relationships between sGPC3N and clinicopathologic features were analyzed and the prognostic impact on overall survival (OS) or disease‐free survival (DFS) was also investigated. Mean and median levels of sGPC3N in healthy controls were 110.12 and 115.95 pg mL−1, respectively, with 185.52 pg mL−1 (mean + 2 SD) being set as the upper limit of the normal range. In HCC patients, sGPC3N levels were significantly increased (mean/median, 405.16/236.19 pg mL−1) compared to healthy controls (p < 0.0001), and 60% of HCC cases (69/115) showed sGPC3N levels that were higher than the upper normal limit. High sGPC3N levels were significantly associated with serum AFP level, high Child‐Pugh score and positive HCV. Kaplan–Meier analysis indicated that elevated pre‐operative sGPC3N was associated with shorter OS and DFS after hepatectomy (p ≤ 0.01). Multivariate analysis revealed elevated sGPC3N as an independent poor prognostic marker for OS (p < 0.05) and DFS (p < 0.01). The pre‐operative sGPC3N level serves as an independent prognostic biomarker in HCC patients.
Treatment Beliefs and Preferences for Psychological Therapies for Weight Management
Authors: Moffitt Robyn , Haynes Ashleigh , Mohr Philip 
Published: March 2015

ObjectiveTreatment beliefs and preferences for psychological therapies were investigated in 80 overweight individuals trying to manage their weight.MethodParticipants read 4 therapy descriptions: cognitive behavioral therapy (CBT), behavior therapy (BT), cognitive therapy (CT), and acceptance and commitment therapy (ACT). They ranked the treatments in order of preference, explained the reason for their preferred choice, and reported their beliefs about each approach.ResultsIndividual CBT (43.42%) and BT (31.58%), delivered face‐to‐face or technologically, were the most preferred treatment options, while ACT (17.12%) and CT (7.89%) were the least preferred. The main reasons cited among those who chose CBT and BT were perceived comprehensiveness and the practical nature of the approach, respectively. Treatment beliefs were strongly predicted by psychological need satisfaction as well as perceived ease and effort.ConclusionsFurther research should ascertain the stability of treatment beliefs and the efficacy of modifying the treatment context to meet individual needs.
Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition
Authors: Miyazaki Masaru , Yoshitomi Hideyuki , Miyakawa Shuichi , Uesaka Katsuhiko , Unno Michiaki , Endo Itaru , Ota Takehiro , Ohtsuka Masayuki , Kinoshita Hisafumi , Shimada Kazuaki , Shimizu Hiroaki , Tabata Masami , Chijiiwa Kazuo , Nagino Masato , Hirano Satoshi , Wakai Toshifumi , Wada Keita , Iasayama Hiroyuki , Okusaka Takuji , Tsuyuguchi Toshio , Fujita Naotaka , Furuse Junji , Yamao Kenji , Murakami Koji , Yamazaki Hideya , Kijima Hiroshi , Nakanuma Yasuni , Yoshida Masahiro , Takayashiki Tsukasa , Takada Tadahiro 
Published: March 2015

AbstractBackgroundThe Japanese Society of Hepato‐Biliary‐Pancreatic Surgery launched the clinical practice guidelines for the management of biliary tract and ampullary carcinomas in 2008. Novel treatment modalities and handling of clinical issues have been proposed after the publication. New approaches for editing clinical guidelines, such as the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, also have been introduced for better and clearer grading of recommendations.MethodsClinical questions (CQs) were proposed in seven topics. Recommendation, grade of recommendation and statement for each CQ were discussed and finalized by evidence‐based approach. Recommendation was graded to grade 1 (strong) and 2 (weak) according to the concept of GRADE system.ResultsThe 29 CQs covered seven topics: (1) prophylactic treatment, (2) diagnosis, (3) biliary drainage, (4) surgical treatment, (5) chemotherapy, (6) radiation therapy, and (7) pathology. In 27 CQs, 19 recommendations were rated strong and 11 recommendations weak. Each CQ included the statement of how the recommendation was graded.ConclusionsThis guideline provides recommendation for important clinical aspects based on evidence. Future collaboration with cancer registry will be a key for assessment of the guidelines and establishment of new evidence. Free full‐text articles and a mobile application of this guideline are available via http://www.jshbps.jp/en/guideline/biliary‐tract2.html.
Cryopreserved arterial grafts as a conduit in outflow reconstruction in living donor liver transplantation
Authors: Ali Mahmoud Abdelwahab , Yong Chee‐Chien , Eng Hock‐Liew , Wang Chih‐Chi , Lin Ting‐Lung , Li Wei‐Feng , Wang Shih‐Ho , Lin Chih‐Che , Yap Anthony , Chen Chao‐Long 
Published: March 2015

AbstractBackgroundFew reports have addressed the use of cryopreserved arterial grafts (CAG) for anterior section drainage in right lobe living donor liver transplantation (RL LDLT), and the impact of atherosclerosis on patency rate (PR) is not well studied. Also, those reports have limited case numbers. The aim of the present study is to report the largest experience with CAG in outflow reconstruction in RL LDLT and the impact of atherosclerosis on its patency.MethodsDuring 2010 and 2011, 62 of 243 patients who underwent LDLT received outflow reconstruction with CAG for RL grafts. Atherosclerosis in CAG was classified into early, intermediate and advanced lesions according to the classification adopted by the American Heart Association: group 1 with grafts having no atherosclerosis or early lesions; and group 2 with grafts having intermediate and advanced lesions. Patency rates of CAG correlated with atherosclerotic change of CAG were retrospectively analyzed.ResultsThe study group comprised 65 CAGs with 1, 3 and 6 months PR of 86.2%, 84.6% and 75.2% respectively. Histopathological examination was successful in 53 CAGs. The 1, 3 and 6 months PR of group with no/early atherosclerosis were 86%, 83.7% and 76.7%, respectively, while for groups with intermediate/advanced lesions they were 90%. However, there was no significant difference between the two groups (P = 0.384).ConclusionsCryopreserved arterial grafts can be used for outflow reconstruction in RL LDLT with a good patency rate. Atherosclerosis appears to have minimal effect on CAG patency, yet further studies with larger cohorts are needed to support our results.
Grease or Sand in the Wheels of Commerce? Firm Level Evidence on Corruption and SMES
Authors: Mendoza Ronald U. , Lim Ricardo A. , Lopez Anne Ong 
Published: March 2015

AbstractBribes can either put ‘grease’ or ‘sand’ in the wheels of commerce, affecting firm performance (at the micro‐level) and, ultimately, economic growth (at the macro‐level). This study examines this issue using a unique and exceptionally rich dataset on over 2000 micro, small and medium scale enterprises in over 30 cities in the Philippines. Using instruments such as industry‐location averages of corruption to deal with endogeneity and drawing on unique contextual information on public–private interactions on bribery, this study finds evidence that corruption greases the wheels of commerce for Philippine SMEs, particularly in cities with poor business environments. Copyright © 2015 John Wiley & Sons, Ltd.
From raw material to dish: pasta quality step by step
Authors: Sicignano Angelo , Di Monaco Rossella , Masi Paolo , Cavella Silvana 
Published: March 2015

AbstractPasta is a traditional Italian cereal‐based food that is popular worldwide because of its convenience, versatility, sensory and nutritional value. The aim of this review is to present a step‐by‐step guide to facilitate the understanding of the most important events that can affect pasta characteristics, directing the reader to the appropriate production steps. Owing to its unique flavor, color, composition and rheological properties, durum wheat semolina is the best raw material for pasta production. Although pasta is traditionally made from only two ingredients, sensory quality and chemical/physical characteristics of the final product may vary greatly. Starting from the same ingredients, there are a lot of different events in each step of pasta production that can result in the development of varieties of pasta with different characteristics. In particular, numerous studies have demonstrated the importance of temperature and humidity conditions of the pasta drying operation as well as the significance of the choice of raw material and operating conditions on pasta quality. © 2015 Society of Chemical Industry