bluuebunny/crossref_metadata_2025_split huggingface dataset:
MMP-9/RECK Imbalance: A Mechanism Associated with High-Grade Cervical Lesions and Genital Infection by Human Papillomavirus and Chlamydia trachomatis
Authors: Discacciati Michelle G. , Gimenes Fabrícia , Pennacchi Paula C. , Faião-Flores Fernanda , Zeferino Luiz C. , Derchain Sophie M. , Teixeira Júlio C. , Costa Maria C. , Zonta Marco , Termini Lara , Boccardo Enrique , Longatto-Filho Adhemar , Consolaro Marcia E.L. , Villa Luisa L. , Maria-Engler Silvya S. 
Published: August 2015

Abstract
Background: Matrix metalloproteinases (MMP) are important enzymes in the tumor microenvironment associated with progression of cervical intraepithelial neoplasia (CIN) toward squamous cell carcinoma (SCC) of the cervix. However, the role of MMPs in the inflammatory process associated with Chlamydia trachomatis infection concomitant with the carcinogenic process driven by HPV has not yet been addressed. In the present study, we analyzed the state of the MMP-9–RECK axis in cervical carcinogenesis.
Methods: The levels of MMP-9 and RECK expression were analyzed by immunocytochemistry in liquid-based cytology samples from 136 women with high-grade cervical lesions (CIN2/CIN3) and cervical SCC diagnosed by LLETZ, and in 196 women without cervical neoplasia or CIN1. Real-time qPCR was performed to analyze expression of MMP-9 and RECK in 15 cervical samples. The presence of HPV-DNA and other genital pathogens was evaluated by PCR.
Results: We found a higher expression of MMP-9 [OR, 4.2; 95% confidence interval (CI), 2.2–7.8] and lower expression of RECK (OR, 0.4; 95% CI, 0.2–0.7) in women with CIN2/CIN3/SCC when compared with women from the control group (no neoplasia/CIN1). A statistically significant association was also found between MMP-9/RECK imbalance and infection by alpha-9 HPV and C. trachomatis. The prevalence of C. trachomatis infection was significantly higher in women with high-grade cervical disease (OR, 3.7; 95% CI, 1.3–11.3).
Conclusions: MMP-9/RECK imbalance in cervical smears is significantly associated with high-grade cervical diseases and infection by alpha-9 HPV and C. trachomatis.
Impact: MMP-9/RECK imbalance during cervical inflammation induced by C. trachomatis might play a role in HPV-mediated cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev; 24(10); 1539–47. ©2015 AACR.
Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera
Authors: Gisslinger Heinz , Zagrijtschuk Oleh , Buxhofer-Ausch Veronika , Thaler Josef , Schloegl Ernst , Gastl Guenther A. , Wolf Dominik , Kralovics Robert , Gisslinger Bettina , Strecker Karin , Egle Alexander , Melchardt Thomas , Burgstaller Sonja , Willenbacher Ella , Schalling Martin , Them Nicole C. , Kadlecova Pavla , Klade Christoph , Greil Richard 
Published: August 2015

Key Points
The novel IFNα-2b, ropeginterferon alfa-2b, administered once every 2 weeks has low toxicity and induces high and sustained response rates in polycythemia vera patients. Ropeginterferon alfa-2b induces significant partial and complete molecular response rates, as reflected by reduction of JAK2 allelic burden.
A method of designing a generic actor model for a professional social network
Authors: Ninawe Swapnil S , Venkataram Pallapa 
Published: August 2015

AbstractThe emergence of social networks have opened a new paradigm for professional groups to student groups to exchange their information with their contemporaries quickly and efficiently. The social networking enables to set up relations among the people (called actors) who share common interests, activities or connections. An actor or a person plays a predominant role in sharing social networking services, hence optimal modelling of an actor is essential. An actor model must be defined with several issues concerning to interests, activities, devices used, etc. In this paper, we present a generic actor model for a professional social network (GAMPSON) by considering actor’s personally identifiable information, professional information, activity, social status, etc. The designed GAMPSON is tested over professional social networks such as agriculture social network and museum social network, where GAMPSON generates unique actors associated with the agriculture and museum social network, and renders relations among the actors. Results demonstrated that it is simple and accurate to generate actors and their relations in any social network along with provision of information over database.
Outcomes of Nonmyeloablative HLA-Haploidentical Blood or Marrow Transplantation With High-Dose Post-Transplantation Cyclophosphamide in Older Adults
Authors: Kasamon Yvette L. , Bolaños-Meade Javier , Prince Gabrielle T. , Tsai Hua-Ling , McCurdy Shannon R. , Kanakry Jennifer A. , Rosner Gary L. , Brodsky Robert A. , Perica Karlo , Smith B. Douglas , Gladstone Douglas E. , Swinnen Lode J. , Showel Margaret M. , Matsui William H. , Huff Carol Ann , Borrello Ivan , Pratz Keith W. , McDevitt Michael A. , Gojo Ivana , Dezern Amy E. , Shanbhag Satish , Levis Mark J. , Luznik Leo , Ambinder Richard F. , Fuchs Ephraim J. , Jones Richard J. 
Published: August 2015

PurposeRecent advances in nonmyeloablative (NMA), related HLA-haploidentical blood or marrow transplantation (haplo-BMT) have expanded the donor pool. This study evaluated the effect of age on NMA haplo-BMT outcomes in patients age 50 to 75 years.Patients and MethodsA retrospective analysis was performed of 271 consecutive patients with hematologic malignancies, age 50 to 75 years, who received NMA, T-cell–replete haplo-BMT with high-dose post-transplantation cyclophosphamide.ResultsThe median age was 61 years, with 115 patients (42%) age 50 to 59, 129 (48%) age 60 to 69, and 27 (10%) age 70 to 75 years. Overall, 84% of patients had intermediate- or high-/very high–risk disease. The 6-month probabilities of grade 3 or 4 acute graft-versus-host disease (GVHD) and nonrelapse mortality (NRM) were 3% and 8%, respectively. Patients in their 50s, 60s, and 70s had 6-month NRM probabilities of 8%, 9%, and 7%, respectively (P = .20). With a median follow-up of 4 years, corresponding 3-year progression-free survival probabilities were 39%, 35%, and 33% (P = .65), and corresponding 3-year overall survival probabilities were 48%, 45%, and 44% (P = .66). Three-year progression-free survival probabilities were 40% in acute myeloid leukemia (n = 65), 39% in aggressive non-Hodgkin lymphoma (n = 83), and 37% in indolent or mantle-cell lymphoma (n = 65). Older patient age was associated with a significantly higher risk of grade 2 to 4 acute GVHD but not grade 3 to 4 acute or chronic GVHD. No statistically significant associations were found between older age (relative to age 50 to 59 years or as a continuous variable) and NRM, relapse, or survival.ConclusionNMA haplo-BMT with post-transplantation cyclophosphamide has encouraging safety and survival outcomes in patients age 50 to 75 years. In patients otherwise fit for BMT, the results support consideration of this approach despite advanced age.
Impact of Subsequent Therapies on Outcome of the FIRE-3/AIO KRK0306 Trial: First-Line Therapy With FOLFIRI Plus Cetuximab or Bevacizumab in Patients With KRAS Wild-Type Tumors in Metastatic Colorectal Cancer
Authors: Modest Dominik P. , Stintzing Sebastian , von Weikersthal Ludwig Fischer , Decker Thomas , Kiani Alexander , Vehling-Kaiser Ursula , Al-Batran Salah-Eddin , Heintges Tobias , Lerchenmüller Christian , Kahl Christoph , Seipelt Gernot , Kullmann Frank , Stauch Martina , Scheithauer Werner , Held Svantje , Möhler Markus , Jung Andreas , Kirchner Thomas , Heinemann Volker 
Published: August 2015

Purpose We investigated choice and efficacy of subsequent treatment, with special focus on second-line therapy, in the FIRE-3 trial (FOLFIRI plus cetuximab [arm A] or bevacizumab [arm B]) for patients with KRAS wild-type metastatic colorectal cancer. Patients and Methods Start of subsequent-line (second or third) therapy was defined as use of an antitumor drug that was not part of the previous regimen. We evaluated choice, duration, and efficacy of subsequent therapy and determined the impact of subsequent-line treatment on outcome of patients in FIRE-3. Results Of 592 patients in the intent-to-treat population, 414 (69.9%) received second-line and 256 (43.2%) received third-line therapy. In subsequent treatment lines, 47.1% of patients originally assigned to arm A received bevacizumab, and 52.2% originally assigned to arm B received either cetuximab or panitumumab. Oxaliplatin was subsequently used in 55.9% (arm A) and 53.2% (arm B) of patients. Second-line therapy was administered for a median duration of 5.0 versus 3.2 months (P < .001) in study arm A versus B. Progression-free (6.5 v 4.7 months; hazard ratio, 0.68; 95% CI, 0.54 to 0.85; P < .001) and overall survival (16.3 v 13.2 months; hazard ratio, 0.70; 95% CI, 0.55 to 0.88; P = .0021) from start of second-line therapy were longer in patients in arm A compared with arm B. Conclusion Our data suggest that the sequence of drug application might be more important than exposure to single agents. In patients with RAS wild-type tumors, first-line application of anti–epidermal growth factor receptor–directed therapy may represent a favorable condition for promoting effective subsequent therapy including antiangiogenic agents.
Reviews Film
Authors: Cziborr Jonathan , Fleischmann Dustin , Incrucio Mars , Jonathan King Justin Ray 
Published: August 2015

Abstract
Like Father, Like Son
Like Father, Like Son (Soshite chichi ni naru, 2013)
Japan Director Hirokazu Koreeda Runtime 120 minutes
An Achievement in Storytelling: A Review of Spike Jonze's Her
Her (2013) USA Director Spike Jonze Runtime 126 minutes
Only Refn Forgives
Only God Forgives (2013) Denmark/Sweden/ Thailand/USA/France Director Nicolas Winding Refn Runtime 90 minutes
Man of Steel
Man of Steel (2013) USA/Canada/UK Director Zack Snyder Runtime 143 minutes
Reviews DVD/Blu-ray
Authors: Gates Brendan , Martin Richard F. , Mayo Jonathan , Rasberry Margaret , Warpole Kailyn N. 
Published: August 2015

Abstract
Laurence Anyways
Laurence Anyways (2012) Canada
Director Xavier Dolan Runtime 168 minutes
DVD USA, 2013 Produced and Distributed by Alliance Viva Film (region 1)
The Killing
The Killing (1956) USA Director Stanley Kubrick Runtime 84 minutes
Blu-ray USA, 2011 Produced and Distributed by The Criterion Collection
A Look into the World of Independent Gaming
Indie Game: The Movie (2012) USA Director Lisanne Pajot and James Swirsky Runtime 94 minutes
DVD USA, 2008 Produced and Distributed by Blink Works Media (region 1)
Jules et Jim
Jules et Jim (1962) France Director François Truffaut Runtime 105 minutes
Dual Format Blu-ray/ DVD USA, 2013 Produced and Distributed by The Criterion Collection (region 1)
A Brief History of Time in 11 Frames
A Brief History of Time (1991) UK/Japan/USA Director Errol Morris Runtime 84 minutes
Dual Format Blu-ray/DVD
USA, 2014 Produced and Distributed by The Criterion Collection (region A/1)
Juego de rol y la actividad matemática
Authors: Camargo Amaya Diana Marcela 
Published: August 2015

<p>Se presenta una metodología de trabajo para la creación de un juego de rol con la concepción de que el juego facilita la enseñanza y el aprendizaje de las matemáticas.</p>La investigación se desarrolla teniendo en cuenta las etapas de: planeación, acción, observación y reflexión, con el objetivo de generar la actividad matemática a partir del juego de rol: <em>Special Agents of the Universe, </em>producto final de esta investigación,<em> </em>donde participan cinco estudiantes que juegan con personajes creados y personalizados por ellos, y un docente de matemáticas que cumple el rol de master. A la hora de jugar este equipo utiliza o consulta con su master los conocimientos matemáticos que necesitan para obtener la victoria en las diferentes partidas. Cada partida dura aproximadamente entre tres y cuatro horas donde la imaginación y las ansias por conocer el final de la historia consumen a los jugadores. <em> </em>
Modelo AHP-VIKOR para handoff espectral en redes de radio cognitiva
Authors: Hernández Suárez César , Páez Ingrid , Giral Ramírez Diego Armando 
Published: August 2015

En este artículo se presenta la propuesta de un algoritmo híbrido para la asignación de espectro en redes de radio cognitiva basado en los algoritmos Analytical Hierarchical Process (AHP) y Multi-Criteria Optimization and Compromise Solution (VIKOR), con el objetivo de mejorar el desempeño de la movilidad espectral de los usuarios secundarios en redes de radio cognitiva.Para evaluar el nivel de desempeño del algoritmo propuesto se realiza un análisis comparativo entre este, el Grey Relational Analysis (GRA) y una asignación de espectro aleatoria (Random). Los dos primeros trabajan con los mismos criterios de decisión: probabilidad de disponibilidad del canal, tiempo estimado de disponibilidad del canal, relación señal a ruido más interferencia y ancho de banda. A diferencia de los trabajos relacionados, la evaluación comparativa se validó a través de una traza de datos reales de ocupación espectral capturados en la banda de frecuencia GSM, que modela el comportamiento real de los usuarios licenciados. En la evaluación de desempeño se utilizaron cinco métricas de evaluación: número promedio acumulado de handoff fallidos, número promedio acumulado de handoff realizados, ancho de banda promedio, retardo promedio acumulado y throughput promedio acumulado.Los resultados del análisis comparativo con los otros dos algoritmos muestran que el algoritmo de handoff AHP-VIKOR propuesto provee el mejor desempeño en la movilidad espectral.
CONEXIONES UNIVERSIDAD - TERRITORIO EN LA ESCENA LATINOAMERICANA: UN ACERCAMIENTO DESDE EL CASO COLOMBIANO
Authors: Castro Ortega Carlos Hernán 
Published: August 2015

<p>El trabajo revela algunos patrones y tendencias espaciales presentes en el sistema de educación superior en Colombia, examinado en dos escalas: urbano-metropolitana y regional-nacional. El estudio de la oferta, la demanda, la capacidad y los productos que entregan las universidades, permitió advertir disparidades y desequilibrios urbano-regionales observados principalmente entre universidades públicas al interior del sistema de educación superior colombiano. Metodológicamente se acudió al análisis cuantitativo y locacional de datos provenientes del SNIES, para identificar tipologías de localización/distribución y examinar aspectos relativos al comportamiento y pertinencia socio-espacial de la educación superior en el país.</p>
Can traditional games be an option in increasing the physical activity of women following mastectomy?
Authors: Bronikowska Małgorzata , Bronikowski Michał , Glapa Agata , Prabucki Bartosz 
Published: August 2015

Summary
Study aim: the purpose of the present study was to investigate the potential of traditional games as a method of increasing the physical activity (PA) of women following mastectomy. A cross-sectional survey during the 20th ONCO Games was conducted and the sample included data from women divided into two groups: up to 50 years old (n = 26) and over 50 years old (n = 86).

Material and methods: PA was assessed using a questionnaire, and the number of steps taking during 30-minute periods was measured using pedometers during each of the games. Exertion was evaluated using Borg’s Scale.

Results: there was no difference in levels of coherence between the age groups. The group of younger women were statistically more active (M = 3.34 days/week) than the older group (M = 2.77 days/week). All the games were evaluated to be of light intensity, with ringo perceived as being statistically more fatiguing in the over 50 age group. The highest number of steps was performed during the game of ring-net-ball (M = 1903 steps/30 min) in both age groups, with older women performing statistically more steps. Similar situations were observed in the cases of pétanque and speedminton. In ringo, the situation was reversed. The lowest number of steps was recorded in pétanque in the younger age group (M = 296 steps/30 min).

Conclusion: this study indicates that in the rehabilitation and recovery process after mastectomy, traditional games could be a bridging link between exercising and sports as they provide not just activity but also a unique and valuable social context.
Human Capacities for Emotion Recognition and their Implications for Computer Vision
Authors: Liebold Benny , Richter René , Teichmann Michael , Hamker Fred H. , Ohler Peter 
Published: August 2015

Abstract
Current models for automated emotion recognition are developed under the assumption that emotion expressions are distinct expression patterns for basic emotions. Thereby, these approaches fail to account for the emotional processes underlying emotion expressions. We review the literature on human emotion processing and suggest an alternative approach to affective computing. We postulate that the generalizability and robustness of these models can be greatly increased by three major steps: (1) modeling emotional processes as a necessary foundation of emotion recognition; (2) basing models of emotional processes on our knowledge about the human brain; (3) conceptualizing emotions based on appraisal processes and thus regarding emotion expressions as expressive behavior linked to these appraisals rather than fixed neuro-motor patterns. Since modeling emotional processes after neurobiological processes can be considered a long-term effort, we suggest that researchers should focus on early appraisals, which evaluate intrinsic stimulus properties with little higher cortical involvement. With this goal in mind, we focus on the amygdala and its neural connectivity pattern as a promising structure for early emotional processing. We derive a model for the amygdala-visual cortex circuit from the current state of neuroscientific research. This model is capable of conditioning visual stimuli with body reactions to enable rapid emotional processing of stimuli consistent with early stages of psychological appraisal theories. Additionally, amygdala activity can feed back to visual areas to modulate attention allocation according to the emotional relevance of a stimulus. The implications of the model considering other approaches to automated emotion recognition are discussed.
Density and activity patterns of ocelot populations in Yasuní National Park, Ecuador
Authors: Salvador Julia , Espinosa Santiago 
Published: August 2015

AbstractOcelots were historically hunted for their skins but habitat loss is now their most serious threat, causing rapid declines in populations throughout their range. Ocelot abundance has been estimated for various locations across the Neotropics, but we still lack this information from some countries, including Ecuador. Knowing whether ocelot abundance is increasing or decreasing is important to assess the conservation status of this species and the conditions of its habitats in the Ecuadorian Amazon and in the region. To determine whether ocelot abundance and its behavior are affected by human-related activities, camera-trap surveys were carried out in two localities of Yasuní National Park (YNP), one that has experienced hunting, oil extraction, and roads (Maxus Road) and one that is largely unaffected by these activities (Lorocachi). During the survey, 35 and 36 individual ocelots were photographed in Maxus Road and Lorocachi, respectively. Population density estimates were similar for both localities, ranging from 0.31 (SE±6) to 0.85 (SE±17) ocelots/km
Primacy analysis in the system of Bulgarian cities
Authors: Dimitrova Zlatinka I. , Ausloos Marcel 
Published: August 2015

Abstract
The concept of "primacy" as introduced by Jefferson
in 1939 in urban geography leads to the notion of
"dominant city" also known as the primate city. Practically,
the notion was extended by Sheppard in view of discussing
some "hierarchy". The type of dominance is not
universal nor any hierarchy reversal. Both can be time and
sample dependent. Thus, as an example taking into consideration
the existence of both pieces of the puzzle, we
consider and discuss the Bulgarian urban system. It is also
interesting to compare data on two groups of cities in different
time intervals: (i) the whole Bulgaria city system
which contains about 250 cities, - studied in the time interval
between 2004 and 2011, and (ii) a system of 33 cities,
- studied over the time interval 1887 till 2010. These latter
cities are selected because the population was already
over 10 000 inhabitants in 1946. It is shown that new
additional indices are interestingly introduced in order to
compensate defects in the Sheppard index. Numerical illustrations
are illuminated through a "length ratio" measure,
which allows to distinguish the (often) observed departures
from the hyperbolic ranking seen by Jefferson.
Effect of VKORC1-1639 G>A polymorphism on warfarin response in east of Turkey / Türkiye’nin doğusunda warfarin yanıtı üzerine VKORC1-1639 G>A polimorfizminin etkisi
Authors: Kiki İlhami , Yıldırım Rahşan , Yıldırım Abdülkadir , Laloğlu Esra , Çadırcı Kenan , Erdem Fuat , Gündoğdu Mehmet 
Published: August 2015

Abstract
Objective: The aim of the present study was to investigate whether the VKORC1 -1639 G>A polymorphisms could determine differences in the warfarin dose required to maintain a therapeutic INR in patients living in east of Turkish.
Methods: A total of 80 patients (45 female and 35 male) aged between 17 and 85 years (mean age 58.96±16.59 years) using warfarin for at least one month and presenting at Atatürk University Medical Faculty Outpatient Clinic between May 2009 and May 2010 were included in the study. Patients underwent genotype investigations and carrier forms of VKORC1 -1639 variants; homozygous (AA), heterozygous (GA) and wild types (GG) were determined.
Results: In AA and GA groups, daily warfarin maintenance doses were statistically significant lower than in GG (p=0.010 and p=0.016, respectively). There was no significant difference between AA and GA groups regarding to warfarin dose (p>0.05). INR values were higher in GA and AA groups than in GG group and differences were statistically significant (p=0.014 and p=0.016, respectively). Also there was no difference between GA and AA gropus in terms of INR.
Conclusion: In conclusion, our study verified the interindividual variability in warfarin maintenance dose due to VKORC1-1639 G>A polymorphism in patients living in east of Turkish. In order to avoid serious bleeding events in warfarin therapy, prescription of warfarin should be done on an individual basis with consideration for the patient’s genetic background.