bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Cooperative Catalysis by Palladium and a Chiral Phosphoric Acid: Enantioselective Amination of Racemic Allylic Alcohols.
Authors: Banerjee Debasis , Junge Kathrin , Beller Matthias 
Published: February 2015

AbstractThe catalytic system consisting of Pd(dba)2, a chiral phosphoric acid, and a phosphoramidite ligand is the key to high enantioselectivity in the title reaction.
ChemInform Abstract: Synthesis of α‐Aryl Esters and Nitriles: Deaminative Coupling of α‐Aminoesters and α‐Aminoacetonitriles with Arylboronic Acids.
Authors: Wu Guojiao , Deng Yifan , Wu Chaoqiang , Zhang Yan , Wang Jianbo 
Published: February 2015

AbstractThe title scalable reaction proceeds via diazotation and metal‐free coupling of the resulting diazo esters or nitriles with arylboronic acids.
ChemInform Abstract: Highly Efficient and Magnetically Separable Nano‐CuFe2O4 Catalyzed S‐Arylation of Thiourea by Aryl/Heteroaryl Halides.
Authors: Hajipour Abdol R. , Karimzadeh Morteza , Azizi Ghobad 
Published: February 2015

AbstractNanosized CuFe2O4 catalyzes the formation of aromatic thioethers from (hetero)aryl halides in the presence of thiourea.
ChemInform Abstract: The Transition‐Metal‐Catalyst‐Free Oxidative Homocoupling of Organomanganese Reagents Prepared by the Insertion of Magnesium into Organic Halides in the Presence of MnCl2·2LiCl.
Authors: Peng Zhihua , Li Na , Sun Xinyang , Wang Fang , Xu Lanjian , Jiang Cuiyu , Song Linhua , Yan Zi‐Feng 
Published: February 2015

AbstractIn addition to the title homocoupling reaction the arylmanganese reagents also react with electrophiles or undergo palladium‐catalyzed cross‐coupling reactions.
ChemInform Abstract: Catalyst‐ and Chromatography‐Free Synthesis of Pyrrole‐Substituted Indolinone Derivatives in Water.
Authors: Ahmad Nazim A. A. , Rokade Sunil M. , Garande Ashok M. , Bhate Prakash M. 
Published: February 2015

AbstractThis novel facile protocol allows the synthesis of pyrrole‐substituted indolinone derivatives via addition of amine (II) to isatins followed by decarboxylation and dehydration.
ChemInform Abstract: From Enantiopure Hydroxyaldehydes to Complex Heterocyclic Scaffolds: Development of Domino Petasis/Diels—Alder and Cross‐Metathesis/Michael Addition Reactions.
Authors: Cannillo Alexandre , Norsikian Stephanie , Tran Huu Dau Marie‐Elise , Retailleau Pascal , Iorga Bogdan I. , Beau Jean‐Marie 
Published: February 2015

AbstractA sequence combining Petasis and Diels—Alder reactions gives access to hexahydroisoindole scaffolds in a one‐step procedure.
ChemInform Abstract: Transition‐Metal‐Free Heterocyclization of 1,3‐Diynes with Nitriles in the Presence of Aqueous Potassium Hydroxide: Synthesis of 2,4‐Disubstituted 5‐[(E)‐2‐Phenylethenyl]‐1,3‐oxazoles.
Authors: Ming Ling , Tang Jialiang , Zhao Xiaoming 
Published: February 2015

AbstractAliphatic 1,3‐diynes such as tetradeca‐6,8‐diyne fail to afford the corresponding products.
ChemInform Abstract: A Practical One‐Pot Synthesis of Coumarins in Aqueous Sodium Bicarbonate via Intramolecular Wittig Reaction at Room Temperature.
Authors: Belavagi Ningaraddi S. , Deshapande Narahari , Sunagar Manjunath G. , Khazi Imtiyaz Ahmed M. 
Published: February 2015

AbstractThe reaction can be scaled up.
ChemInform Abstract: A New Route to the Versatile Synthesis of Thiopyrano[2,3‐b:6,5‐b′]diindoles via 2‐(Alkylthio)‐indole‐3‐carbaldehydes.
Authors: Jha Mukund , Edmunds Michael , Lund Kate‐lyn , Ryan Ashley 
Published: February 2015

AbstractTitle compounds (III), (V), (VII), and (IX) are prepared from starting indolecarbaldehydes (I) and (VIII) (accessible via Vilsmeier‐Haack formylation of respective alkylthioindoles) by ethylenediamine‐diacetate‐mediated reaction with indoline‐2‐thiones (II), (IV), and (VI).
ChemInform Abstract: Efficient Syntheses of Fluorine‐Containing Pyrimido[5,4‐c]quinolines and Benzo[h][1,6]naphthyridines by Condensation Reactions of 3‐Trifluoroacetylquinolin‐4‐amine with Aldehydes and Ketones.
Authors: Okada Etsuji , Hatakenaka Mizuki , Nakano Shiro , Sakaemura Takushi , Mori Takashi , Terauchi Terukazu 
Published: February 2015

Abstract3‐Trifluoroacetyl‐4‐aminoquinoline (I) undergoes a three‐component condensation reaction with aldehydes ammonia to afford pyrimidoquinoline derivatives as single or major products.
ChemInform Abstract: A Facile Access to Highly Functionalized Triphenylphosphoranylidene Succinimides Through a Three‐Component Reaction and DFT Investigation of the Reaction Mechanism.
Authors: Esmaeili Abbas Ali , Khoddam‐Mohammadi Hanieh , Moradi Abbas , Davamdar Ehsan , Izadyar Mohammad , Khavani Mohammad , Islami Mohammad Reza 
Published: February 2015

AbstractA novel one‐pot reaction of zwitterions generated in situ from triphenylphosphine and acetylenic esters with aroyl isocyanates affords the title compounds (IV) without using any catalyst or activation.
ChemInform Abstract: Rhenium‐Catalyzed Dehydration and Deoxydehydration of Alcohols and Polyols: Opportunities for the Formation of Olefins from Biomass
Authors: Raju Suresh , Moret Marc‐Etienne , Klein Gebbink Robertus J. M. 
Published: February 2015

AbstractReview: 96 refs.
Variation of Ventilation Practices With Center Volume After Pediatric Heart Surgery
Authors: Gupta Punkaj , Tang Xinyu , Gossett Jeffrey M. , Gall Christine M. , Lauer Casey , Rice Tom B. , Wetzel Randall C. 
Published: February 2015

ABSTRACTBackgroundThis study was designed to evaluate the odds of mechanical ventilation and duration of mechanical ventilation after pediatric cardiac surgery across centers of varying center volume using the Virtual PICU Systems database.HypothesisChildren receiving cardiac surgery at high‐volume centers will be associated with lower odds of mechanical ventilation and shorter duration of mechanical ventilation, compared with low‐volume centers.MethodsPatients age <18 years undergoing operations (with or without cardiopulmonary bypass) for congenital heart disease at one of the participating intensive care units in the Virtual PICU Systems database were included (2009–2013). Logistic regression models and Cox proportional hazards models were fitted for the probability of conventional mechanical ventilation and duration of mechanical ventilation, respectively, to investigate the difference in the outcomes between different center volume groups with/without adjustment for other risk factors.ResultsA total of 10 378 patients from 43 centers qualified for inclusion. Of these, 7648 (74%) patients received conventional mechanical ventilation after cardiac surgery. Higher center volume was significantly associated with lower odds of mechanical ventilation after cardiac surgery (odds ratio: 2.68, 95% confidence interval: 2.15–3.35). However, patients receiving mechanical ventilation in these centers were associated with longer duration of mechanical ventilation, compared with lower‐volume centers (hazard ratio: 1.26, 95% confidence interval: 1.16–1.37). This association was most prominent in the lower surgical‐risk categories.ConclusionsLarge clinical practice variations were demonstrated for mechanical ventilation following pediatric cardiac surgery among intensive care units of varied center volumes.
Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer
Authors: Siraj Abdul K. , Prabhakaran Sarita , Bavi Prashant , Bu Rong , Beg Shaham , Hazmi Mohsen Al , Al‐Rasheed Maha , Al‐Assiri Mohammed , Sairafi Rami , Al‐Dayel Fouad , Al‐Sanea Nasser , Uddin Shahab , Al‐Kuraya Khawla S. 
Published: February 2015

BACKGROUNDLynch syndrome (LS; hereditary nonpolyposis colorectal cancer) is a common cause of hereditary colorectal cancer (CRC). CRC is the most common cancer diagnosed among males in Saudi Arabia but to the authors' knowledge there is a lack of data regarding the prevalence of LS in patients with CRC. There currently are no clear guidelines for the selection criteria for these patients to screen for LS.METHODSA comprehensive molecular characterization was performed in a cohort of 807 CRC cases by immunohistochemical and microsatellite analysis using polymerase chain reaction. BRAF mutation screening, high CpG island methylator phenotype, and analysis for germline mutations were performed in 425 CRC samples. These were all high microsatellite instability (MSI‐H) samples (91 cases), all low MSI samples (143 cases), and selected cases from the microsatellite stable group (191 cases) that met revised Bethesda guidelines.RESULTSPolymerase chain reaction identified 91 MSI‐H cases (11.3%) and sequencing revealed mismatch repair germline mutations in 8 CRC cases only. Of the total of 807 CRC cases, these 8 cases (0.99%) were MSI‐H, met the revised Bethesda guidelines, and did not harbor BRAF mutations.CONCLUSIONSThe results of the current study confirmed cases of LS in approximately 1.0% of CRC samples and reflects the efficacy of screening among MSI‐H cases that lack BRAF mutations. This comprehensive study from Saudi Arabia will help in implementing a universal screening/reflex testing strategy in a clinical setting in Saudi Arabia and in conducting a national screening program that benefits both patients and their relatives. Cancer 2015;121:1762–1771. © 2015 American Cancer Society.
Increasing diagnosis of subclinical thyroid cancers leads to spurious improvements in survival rates
Authors: Ho Allen S. , Davies Louise , Nixon Iain J. , Palmer Frank L. , Wang Laura Y. , Patel Snehal G. , Ganly Ian , Wong Richard J. , Tuttle R. Michael , Morris Luc G. T. 
Published: February 2015

BACKGROUNDSurvival rates are commonly used to measure success in treating cancer, but can be misleading. Modern diagnostic practices can lead to the appearance of improving cancer survival, as tumors are diagnosed earlier (lead‐time bias) or as an increasing proportion are slow‐growing (length bias), whereas the actual burden of cancer deaths is unchanged. Increasingly, more subclinical thyroid cancers are being diagnosed. The objective of the current study was to determine whether thyroid cancer survival rates have been affected by this phenomenon.METHODSThe authors analyzed survival data from patients with thyroid cancer who were treated at Memorial Sloan Kettering Cancer Center (MSKCC) from 1950 to 2005, and United States population‐based incidence, prevalence, and survival data from 1973 to 2009 in the Surveillance, Epidemiology, and End Results data set.RESULTSUS thyroid cancer incidence has increased 3‐fold from 1975 to 2009. Over time, the proportion of thyroid cancers that are subcentimeter in size has increased from 23% (1983) to 36% (2009). At MSKCC, this percentage rose from 20% (1950) to 35% (2005). The incidence rates of large tumors (>6 cm) and distant metastasis have not changed. In the United States, 10‐year relative survival improved from 95.4% to 98.6% (1983‐1999). At MSKCC, 10‐year disease‐specific survival improved from 91.1% to 96.1% (1950‐2005). However, when stratified by tumor size and stage, no changes in survival outcomes were observed. US thyroid cancer mortality rates have remained stable (1975‐2009).CONCLUSIONSModern medical practices increasingly uncover small, asymptomatic thyroid cancers. Survival rates appear improved, but this finding is spurious, attributable instead to shifts in the characteristics of disease being diagnosed. Relying on survival rates to measure success in treating thyroid cancer may reinforce inappropriately aggressive management. Treatment decisions in thyroid cancer should be made based on mortality, not survival data. Cancer 2015;121:1793–1799. © 2015 American Cancer Society.
FNA, core biopsy, or both for the diagnosis of lung carcinoma: Obtaining sufficient tissue for a specific diagnosis and molecular testing
Authors: Coley Shana M. , Crapanzano John P. , Saqi Anjali 
Published: February 2015

BACKGROUNDIncreasingly, minimally invasive procedures are performed to assess lung lesions and stage lung carcinomas. In cases of advanced‐stage lung cancer, the biopsy may provide the only diagnostic tissue. The aim of this study was to determine which method—fine‐needle aspiration (FNA), core biopsy (CBx), or both (B)—is optimal for providing sufficient tissue for rendering a specific diagnosis and pursuing molecular studies for guiding tumor‐specific treatment.METHODSA search was performed for computed tomography–guided lung FNA, CBx, or B cases with rapid onsite evaluation. Carcinomas were assessed for the adequacy to render a specific diagnosis; this was defined as enough refinement to subtype a primary carcinoma or to assess a metastatic origin morphologically and/or immunohistochemically. In cases of primary lung adenocarcinoma, the capability of each modality to yield sufficient tissue for molecular studies (epidermal growth factor receptor, KRAS, or anaplastic lymphoma kinase) was also assessed.RESULTSThere were 210 cases, and 134 represented neoplasms, including 115 carcinomas. For carcinomas, a specific diagnosis was reached in 89% of FNA cases (33 of 37), 98% of CBx cases (43 of 44), and 100% of B cases (34 of 34). For primary lung adenocarcinomas, adequate tissue remained to perform molecular studies in 94% of FNA cases (16 of 17), 100% of CBx cases (19 of 19), and 86% of B cases (19 of 22). No statistical difference was found among the modalities for either reaching a specific diagnosis (p = .07, Fisher exact test) or providing sufficient tissue for molecular studies (p = .30, Fisher exact test).CONCLUSIONSThe results suggest that FNA, CBx, and B are comparable for arriving at a specific diagnosis and having sufficient tissue for molecular studies: they specifically attained the diagnostic and prognostic goals of minimally invasive procedures for lung carcinoma. Cancer (Cancer Cytopathol) 2015;123:318–26. © 2015 American Cancer Society.
Colour preference for Taiwanese floral pattern fabrics
Authors: Hsu Mei‐Yun , Ou Li‐Chen , Guan Shing‐Sheng 
Published: February 2015

AbstractA psychophysical experiment was carried out to investigate factors affecting colour preference for Taiwanese floral pattern fabrics, as a case study of object colour preference. A total of 175 test images of Taiwanese fabrics were used as the stimuli presented on a calibrated computer display. The images were generated on the basis of 5 existing Taiwanese fabrics, each manipulated into 35 images by changing the fabric colour. The 35 colours were selected to cover the most frequently used colours for existing Taiwanese fabrics. The 175 test images were assessed by 76 Taiwanese observers in terms of 9 semantic scales, including Taiwanese style/non‐Taiwanese style, Japanese style/non‐Japanese style, splendid/plain, traditional/modern, active/passive, warm/cool, heavy/light, like/dislike and harmonious/disharmonious. The experimental results reveal two underlying factors: “Splendidness” and “Harmony.” The like/dislike response was found to highly correlate with harmonious/disharmonious, but have poor correlation with Taiwanese style/non‐Taiwanese style. The study also reveals several factors affecting colour preference for Taiwanese fabrics, including the interaction effect of colour and pattern, observer's general liking for the object, and the effect of user experience. These findings can help develop a more robust, comprehensive theory of object colour preference. © 2015 Wiley Periodicals, Inc. Col Res Appl, 41, 43–55, 2016
An analytic measure of perceptual factors for color composition
Authors: Hu Guosheng , Sheng Ai , Zhang Yizhong , Pan Zhigeng , Zhang Mingmin 
Published: February 2015

AbstractColor images are usually observed as integrated objects, or called color gestalt. That is why color effect of image is not only affected by the color components themselves, but also determined remarkably by the image constructive frame, which holds the colors. Although, previous researchers have already explored this issue, the conclusions are usually descriptive principles that one should keep in mind for color designing. Precise quantification for image composition of color gestalt is still an ignored field in color research domain. As the use of computer‐aided design (CAD) increases in the color design field, more quantifiable measures for constructive feature factors that affect color gestalt are needed. In this article, we introduce a three‐dimensional model of image composition that can both quantify the effect of color gestalt and rebuild image composition to acquire certain color effect for color combination. This method pioneers a new perspective of appreciating the influence of image construction on color combination effect, and a new way of researching color by affective computing or Kansei engineering technology. To test the feasibility of the scale model by a usage study, an interactive toolkit was also built. Practice has confirmed that this method is a technical meaning in application technically meaningful approach, and will spur further research on color composition. © 2015 Wiley Periodicals, Inc. Col Res Appl, 41, 165–174,
2016
Mitigation of Chemical Membrane Degradation in Fuel Cells: Understanding the Effect of Cell Voltage and Iron Ion Redox Cycle
Authors: Wong Ka Hung , Kjeang Erik 
Published: February 2015

AbstractChemical membrane degradation through the Fenton’s reaction is one of the main lifetime‐limiting factors for polymer‐electrolyte fuel cells. In this work, a comprehensive, transient membrane degradation model is developed to capture and elucidate the complex in situ degradation mechanism. A redox cycle of iron ions is discovered within the membrane electrolyte assembly, which sustains the FeII concentration and results in the most severe chemical degradation at open circuit voltage. The cycle strength is critically reduced at lower cell voltages, which leads to an exponential decrease in FeII concentration and associated membrane degradation rate. When the cell voltage is held below 0.7 V, a tenfold reduction in cumulative fluoride release is achieved, which suggests that intermediate cell voltage operation would efficiently mitigate chemical membrane degradation and extend the fuel cell lifetime.
Flow cytometric analysis of the graft‐versus‐Leukemia‐Effect After Hematopoietic Stem Cell Transplantation in Mice
Authors: Schmidt Felix , Hilger Nadja , Oelkrug Christoper , Svanidze Ellen , Ruschpler Peter , Eichler Wolfram , Boldt Andreas , Emmrich Frank , Fricke Stephan 
Published: February 2015

AbstractAcute Graft‐versus‐Host‐Disease (aGvHD) is one of the major complications following allogeneic hematopoietic stem cell transplantation (HSCT). Although rather helpful, the use of conventional immunosuppressive drugs leads to general immunosuppression and is toxic. The effects of CD4+ T‐cells, in respect to the development of aGvHD, can be altered by administration of antihuman CD4 monoclonal antibodies, here MAX.16H5 IgG1. This approach must be tested for possible interference with the Graft‐versus‐Leukemia‐Effect (GvL). Thus, in vitro experiments were conducted, exposing P815 leukemic cells to bone marrow and splenocytes from cd4−/−‐C57Bl/6 mice transgenic for human CD4 and HLA‐DR3 (triple transgenic mice, [TTG]) as well as previously irradiated splenocytes from Balb/cwt mice. Using flow cytometry, the vitality of the various malignant and graft cells was analyzed over the course of 4 days. The survival rate of P815 cells did not change significantly when exposed to MAX.16H5 IgG1, neither did the viability of the graft cells. This provides evidence that MAX.16H5 IgG1 does not impair the GvL effect in vitro. Additionally, P815‐Balb/cwt leukemic mice were transplanted with P815GFP cells, bone marrow, and splenocytes from TTG mice with and without MAX.16H5 IgG1. Without transplantation, P815GFP leukemic cells could be detected by flow cytometry in the liver, the bone marrow, and the spleen of recipients. The antibodies prevented aGvHD while leaving the GvL effect intact. These findings indicate no negative effect of MAX.16H5 IgG1 on the GvL effect in vitro and in vivo after HSCT in a murine model. © 2015 International Society for Advancement of Cytometry
Intelligent file transfer for smart handheld devices based on mobile cloud computing
Authors: Chen Lien‐Wu , Ho Yu‐Fan , Kuo Wei‐Ting , Tsai Ming‐Fong 
Published: February 2015

SummaryMost methods of file transfer between mobile devices have to take considerable time to obtain and input target identifiers. To speed up file sharing of mobile devices, an intelligent file transfer framework is designed based on mobile cloud computing. Only single‐finger action is performed in the proposed framework, which just drags the file to the target face on the touchscreen of a mobile device. The dragged file can be transmitted to the target receiver who can either get the file immediately as her/his mobile device is online or receive the file later after connecting to the Internet. Our framework provides the following features: (i) users do not need to know the target identifier in advance; (ii) users do not need to input identity information by themselves; and (iii) users can select a specific target among multiple candidates from the camera of a mobile device. The intelligent file transfer framework reveals an efficient architecture and innovative user interfaces to transfer files between mobile devices, which can significantly reduce the complexity and difficulty of file sharing. An Android‐based prototype is implemented to verify the feasibility and superiority of our framework. Experimental results show that our approach outperforms existing schemes and can save large amounts of time in file sharing for mobile users. Copyright © 2015 John Wiley & Sons, Ltd.
Association between metformin therapy and incidence, recurrence and mortality of prostate cancer: evidence from a meta‐analysis
Authors: Deng Dan , Yang Yuan , Tang Xiaojun , Skrip Laura , Qiu Jingfu , Wang Yang , Zhang Fan 
Published: February 2015

AbstractObjectivePrevious studies suggested that metformin is associated with decreased risk of cancer; however, results specifically addressing the potential association with prostate cancer were limited and contradictory. This study considers the association between metformin and the incidence, mortality and recurrence of prostate cancer by performing a meta‐analysis of observational studies.MethodsLiteratures published before January 2014 were searched by using databases of PubMed and Embase. Pooled relative risks (RRs) were determined using a random effects model to evaluate the strength of association between metformin therapy and risk of prostate cancer.ResultsThirteen studies involving a total of 334 532 participants were included in this meta‐analysis. Compared with the control group, metformin therapy was associated with significantly decreased incidence of prostate cancer [RR = 0.88, 95% confidence interval (CI) [0.78, 0.99], p = 0.03, I2 = 74.7%]. However, metformin therapy was not associated with decreased all‐cause mortality (RR = 1.07, 95% CI [0.86, 1.32], p = 0.55, I2 = 58.2%) or decreased recurrence of prostate cancer (RR = 0.90, 95% CI [0.75, 1.09], p = 0.27, I2 = 0.0%). No publication bias was detected (pBegg = 0.55, pEgger = 0.46).ConclusionsThe present study suggested that metformin therapy may decrease the incidence of prostate cancer but that there was no association between the treatment and all‐cause mortality or recurrence. It is recommended that this finding should be considered carefully and confirmed with further studies. Copyright © 2015 John Wiley & Sons, Ltd.