bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the dynamics of older person care: a qualitative exploration of the intersection between formal and informal caregiving from the perspectives of registered nurses in Greece
Authors: Xiarchi Lamprini Maria , Nässén Kristina , Palmér Lina , Cowdell Fiona , Lindberg Elisabeth 
Published: August 2024

AbstractIn the evolving landscape of older person care, the imperative to explore holistic approaches persists, especially in regions with distinct societal norms around informal caregiving. The deeply ingrained tradition of familial caregiving, often led by female family members, has historically compensated for healthcare system gaps in less integrated systems. Hence, societal expectations may affect registered nurses’ experiences and impact the quality of care for older persons. This study aims to describe the meaning of caring for older persons in care settings in Greece. Ten in-depth interviews with registered nurses in older person care settings underwent qualitative thematic analysis. Four themes emerged from the analysis: (i) Living and bonding with older people as a basis for caring, (ii) Caring as a double-faced fulfillment, (iii) A sense of insufficiency in the caring relationship, and (iv) The encounter of existential issues creating loneliness. This research provides insights into the meaning of caring for older persons, highlighting the experiences of the closest professional caregivers of older individuals. A specific capture of the entanglement of cultural norms, societal expectations, and their impact on professional caregivers’ experiences may contribute to quality care provision in systems rooted in familial caregiving traditions.
NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population
Authors: Wang Min , Shen Ying , Gao Yuan , Chen Huaqiu , Duan Fuhui , Li Siying , Wang Guangming 
Published: August 2024

Abstract
Background
Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS. The quinone oxidoreductase 1 gene (NQO1) has antioxidant, anti-inflammatory, and cytoprotective properties. Thus, in this study, we investigated the relationship between NQO1 gene polymorphism and the risk of IS.

Methods
Peripheral blood was collected from 143 patients with IS and 124 the control groups in Yunnan, China, and NQO1 rs2917673, rs689455, and rs1800566 were genotyped. Logistic regression was used to analyze the relationship between the three NQO1 loci and IS susceptibility. The difference in the expression levels of NQO1 between the control groups and IS groups was verified using public databases and enzyme-linked immunosorbent assay.

Results
The rs2917673 locus increased the risk of IS by 2.375 times in TT genotype carriers under the co-dominance model compared with CC carriers and was statistically associated with the risk of IS (OR = 2.375, 95% CI = 1.017–5.546, P = 0.046). In the recessive model, TT genotype carriers increased IS risk by 2.407 times compared with CC/CT carriers and were statistically associated with the risk of IS (OR = 2.407, 95% CI = 1.073–5.396, P = 0.033).

Conclusions
NQO1 rs2917673 polymorphism is significantly associated with IS. Mutant TT carriers are risk factors for IS.
Integration of multiomics features for blood-based early detection of colorectal cancer
Authors: Gao Yibo , Cao Dandan , Li Mengfan , Zhao Fuqiang , Wang Pei , Mei Shiwen , Song Qianqian , Wang Pei , Nie Yanli , Zhao Wei , Wang Sizhen , Yan Hai , Wang Xishan , Jiao Yuchen , Liu Qian 
Published: August 2024

Abstract
Background
Early detection of colorectal cancer (CRC) significantly enhances patient outcomes. Conventional CRC screening tools, like endoscopy and stool-based tests, have constraints due to their invasiveness or suboptimal patient adherence. Recently, liquid biopsy employing plasma cell-free DNA (cfDNA) has emerged as a potential noninvasive screening technique for various malignancies.

Methods
In this research, we harnessed the Mutation Capsule Plus (MCP) technology to profile an array of genomic characteristics from cfDNA procured from a single blood draw. This profiling encompassed DNA methylation, the 5’ end motif, copy number variation (CNV), and genetic mutations. An integrated model built upon selected multiomics biomarkers was trained using a cohort of 93 CRC patients and 96 healthy controls.

Results
This model was subsequently validated in another cohort comprising 89 CRC patients and 95 healthy controls. Remarkably, the model achieved an area under the curve (AUC) of 0.981 (95% confidence interval (CI), 0.965–0.998) in the validation set, boasting a sensitivity of 92.1% (95% CI, 84.5%-96.8%) and a specificity of 94.7% (95% CI, 88.1%-98.3%). These numbers surpassed the performance of any single genomic feature. Importantly, the sensitivities reached 80% for stage I, 89.2% for stage II, and were 100% for stages III and IV.

Conclusion
Our findings underscore the clinical potential of our multiomics liquid biopsy test, indicating its prospective role as a noninvasive method for early-stage CRC detection. This multiomics approach holds promise for further refinement and broader clinical application.
Effect of halogens on 3-[4-(dimethylamino) phenyl]-1-phenylprop-2-en-1-ones: development of a new class of monoamine oxidase-B inhibitors
Authors: Hasan Haydara Ammar , Lee Jiseong , Kumar Sunil , Alfarraj Saleh , Alharbi Sulaiman Ali , Pant Manu , Kim Hoon , Mathew Bijo 
Published: August 2024

AbstractFive dimethylamino-based chalcone derivatives (AC) were synthesized and evaluated for their inhibition degree against monoamine oxidase (MAO) enzymes. All AC compounds showed better inhibitory activity against MAO-B than that against MAO-A. AC4 showed the highest inhibitory ability with an IC50 value of 0.020 µM, similar to that of a reference drug safinamide (IC50 = 0.019 µM) against MAO-B, followed by AC1 (IC50 = 0.068 µM) and AC3 (IC50 = 0.083 µM). Substituent -F in ring A (AC4) increased the MAO-B inhibition, followed by -H (AC1), -Br (AC3), and -Cl (AC2). The selectivity index (SI) value of AC4 was high (SI = 82.00) as well as other compounds (44.41 to 98.15). AC4 was found to be a reversible inhibitor as confirmed through analysis using the dialysis method. Interestingly, AC4 was observed to be a noncompetitive MAO-B inhibitor with a rare case and with Ki values of 0.011 ± 0.0036 µM. These experiments confirmed that AC4 is a reversible and potent selective inhibitor of MAO-B. Molecular docking experiments revealed that AC4 showed the highest inhibitory activity with a docking score (-9.510 kcal/mol). A study using molecular dynamics modeling revealed that the protein–ligand complex was more stable. It was observed that AC4 was non-cytotoxic in the study using L929 cell line. In conclusion, compound AC4 shows promise as a MAO-B inhibitor.
Surface air temperature anomalies over Antarctica and the Southern ocean induced by interactions between the interdecadal Pacific oscillation and Atlantic multidecadal oscillation
Authors: Yu Lejiang , Zhong Shiyuan , Sui Cuijuan , Sun Bo 
Published: August 2024

AbstractPrevious research has explored the impact of the Interdecadal Pacific Oscillation (IPO) and Atlantic Multidecadal Oscillation (AMO) on Antarctic surface air temperature (SAT) variability. However, a notable gap remains in our comprehension concerning the response of Antarctic SAT to the four phase combinations of IPO and AMO. In this study, we unveil unique patterns of Antarctic SAT anomalies during four distinct sub-periods based on the phases of IPO and AMO. Notably, Antarctic SAT anomalies exhibit a considerable seasonality, with the most pronounced (weakest) anomalies occurring during the austral winter (summer), a phenomenon consistent across all four sub-periods. These different anomalous SST patterns trigger varying convective rainfall patterns, consequently initiating distinct wavetrains that propagate into the Southern Ocean. These different wavetrains, in turn, induce variations in sea level pressure and surface wind fields, resulting in different Antarctic SAT anomalies primarily through mechanisms related to horizontal thermal advection and downward longwave radiation.
Border crossings and connections
Authors: Weinhold Martin 
Published: August 2024

AbstractFrom 30 September 2023 to 7 January 2024, the Nobel Prize Museum in Stockholm presented the show Fungi—In Art and Science. For the exhibition, an alliance of scientists, artists, and designers was brought together that overcame all the alleged borders between the disciplines, between the scientific and the creative world. This special exhibition is the starting point to take on a tour where it is about crossing borders and growing connections when working with fungi. My interview partners represent perfectly the different angles from which you can take a look onto the kingdom of fungi. There is the person without previous knowledge but with a profound artistic understanding who got mesmerized by the subject-matter, which he didn’t realize it existed before—Karl-Johan Cottman. There is the scientist, being knee-deep in fungi matter who discovered the arts for an extension of her scientific understanding—Vera Meyer. And last but not least there is the person living passionately for the arts who found fungi mesmerizing for both art creation and progressive/sustainable production—Phil Ross. So, there are three threads weaving one fungal fabric. Have fun reading it!
Development of a new patient-reported outcome measure for complex cryptoglandular fistulas (20-Item complex cryptoglandular fistula questionnaire™): a qualitative study
Authors: McCurdy Jeffrey D. , Crooks Patrick , Gwaltney Chad , Krupnick Robert , Cadogan Kathy-Ann , Karki Chitra 
Published: August 2024

Abstract
Background
There are limited tools to measure the burden of disease and effectiveness of medical/surgical interventions in patients with cryptoglandular fistulas. The aim of this study was to explore concepts that are relevant and important to patients with complex cryptoglandular fistulas (CCF) and to develop a patient-centred, disease-specific, patient-reported outcome measure (PROM) to assess symptom burden and impacts of CCF.

Methods
A targeted literature review was conducted, followed by one-to-one telephone interviews with five colorectal surgeons (USA, n = 3; UK, n = 1; Spain, n = 1) and 20 US adult patients with CCF to inform the development of a conceptual model and a CCF-specific PROM. The targeted literature review informed the development of the preliminary conceptual model and identified a PROM in the literature that was used as a reference to generate the draft CCF-specific PROM. The colorectal surgeon interviews provided insights on the experience of patients with CCF to refine the conceptual model, formulate probing questions for use in patient interviews, and to develop the draft CCF-specific PROM. Patients’ descriptions of their experiences with symptoms and the impacts on their lives and evaluation of the draft CCF-specific PROM in concept elicitation and cognitive interviews were used to develop the final conceptual model and final CCF-specific PROM.

Results
Ten symptoms (odour, pain during bowel movement, abscess, post-operative pain, discharge/drainage/leakage, anal/perianal pain, inflammation/swelling, skin irritation, bleeding and itchiness) and 11 impacts (discomfort, inability to exercise, embarrassment, difficulty sitting, worry about disease, adapted life to maintain hygiene, negatively impacted social life/isolation, inability to perform daily activities, reduced interest in sex, negatively impacted intimate relationships and negatively impacted mood) were reported as most salient by patients. The patient experience, clinician perspective, and literature review provided input to item generation. Evaluation of relevance and patient understanding through cognitive interviews with patients provided evidence for the content validity of the new patient-reported outcome measure: the 20-item Complex Cryptoglandular Fistula Questionnaire™ (CCFQ-20™).

Conclusion
The CCFQ-20™ is a new clinician-guided, patient-validated, disease-specific patient-reported outcome measure that measures disease impact and quality of life in patients with CCF.
The development of ski areas and its relation to the Alpine economy in Switzerland
Authors: Troxler Pascal , Roller Marcus , Bandi Tanner Monika 
Published: August 2024

AbstractCableways alleviate access to the Alps and were crucial in establishing the skiing tourism boom of the after-war years. Moreover, cableway operators employ a large share of residents, are complemented by tourism-related services and are therefore a key economic pillar in otherwise laggard regions. We exploit comprehensive historical data of all ever-built cableways in Switzerland linked to income and population data to show how much ski area access benefits the municipalities’ economy compared to similar municipalities without such access on their territory. Evaluating difference-in-differences, we find that opening a ski area between 1940 and 1980 is related to economic growth that persists until today. Particularly, it attracted new residents and created more productive employment opportunities in tourism-related services, thereby raising incomes and tax revenues. Our results contribute to the debate of what economic risks municipalities with access to ski areas face once the decreasing snowpack forces a ski area to close.
A study of the impact of entrance space on indoor air quality in vernacular dwellings in desert areas during sandstorms
Authors: Zhang Xinyu , Liang Yushu , Shi Shanshan , Shen Guofeng 
Published: August 2024

AbstractAlxa League, located in the western part of Inner Mongolia, China, frequently suffers from sandstorms. Such dusty conditions result in sharp increases in respirable particulate matter (PM10) concentration in outdoor and indoor environments, posing a significant health risk to local inhabitants. Vernacular dwellings in this area feature a specific floor plan that includes an entrance space to safeguard indoor air quality during sandstorms while being compatible with the local climate. This study utilises CONTAM, a multizone indoor air quality and ventilation analysis computer program, and field measurements to quantitatively evaluate the effectiveness of the entrance space in protecting indoor air quality against ambient PM10 pollution under both dusty and normal conditions. The simulation results reveal that the entrance space can effectively mitigate PM10 pollution in the middle room, lowering the average concentration from 47.0 μg/m3 to 37.5 μg/m3 during dust periods. However, PM10 pollution may increase in the entrance space, reaching an average concentration of up to 70.0 μg/m3. Experimental outcomes align with the simulated results. Given that construction activities exacerbate desertification and frequent sandstorms, the above findings help identify the optimal design strategies for energy-efficient green vernacular dwellings in the targeted desert area, promoting environmental harmony and addressing climate change challenges.
Exploring the potential of arecanut fibers and fly ash in enhancing the performance of self-compacting concrete
Authors: Marulasiddappa Sreedhara B. , Khan H Asif , Mailar Gireesh , Balreddy Muttana S. , Kuntoji Geetha , Naganna Sujay Raghavendra 
Published: August 2024

AbstractSelf-compacting concrete (SCC) is an innovative material for construction that offers excellent workability and flowability while achieving effective and uniform compaction without the need for external vibration. Using an experimental approach, this study investigates the effect of incorporating arecanut fibers on the performance of self-compacting concrete (SCC). The focus is on optimizing the fiber content for improved concrete characteristics. The study examines three different fiber lengths (8 mm, 10 mm, and 12 mm) and three volume fractions (1%, 2%, and 3%) while partially replacing 30% of the cement by weight with fly ash. Tests on the workability of the SCC mixes revealed favorable characteristics: slump flow between 650 and 750 mm, T500 slump flow time of 2–5 s, V-funnel time of 5–10 s, L-box ratio of 0.8–1.0, and J-ring values within 0–10 mm as recommended by EFNARC guidelines. Furthermore, incorporating 30% fly ash and arecanut fibers significantly enhanced the hardened properties of the SCC, particularly its compressive strength. A concrete mix containing 2% of 10-mm long arecanut fibers achieved a compressive strength of 40.26 MPa, which is about 15.14% increase compared to the reference strength of 35 MPa. Similarly, using a 1% volume fraction of 12 mm arecanut fibers increased the split tensile strength by 14.04% and the flexural strength by 35.87% compared to the control mix. Fly ash and arecanut fibers enhance the durability of SCC by reducing Coulomb charges and improving resistance to chloride penetration. However, the increased water absorption rate of the fibers can lead to increased overall water absorption in the concrete. Microstructural analysis (SEM) revealed improved bonding and reduced voids, further supporting enhanced durability. Additionally, EDX analysis confirmed the presence of various elements from cement and fly ash, providing valuable data for evaluating the long-term performance of these SCC mixes.
The Cibarco anticline of the northernmost San Jacinto fold belt: Possible influence of mud diapirism on the Neogene to the recent evolution of the structure where the first oil and gas wells were drilled in Colombia
Authors: Mora-Bohórquez Josué Alejandro , Ruiz Juan Camilo , Santamaría Luis , Veloza Gabriel , Gómez Christian , Montaña Jorge 
Published: August 2024

The Cibarco anticline, located in the northwestern South American convergent margin, is a long (approximately 40 km) and narrow (2.5 km wide), south-southwest–north-northeast-trending structure that separates two much wider depocenters, the Tubará-Juan de Acosta depocenter (approximately 20 km wide) to the west, and the Sabanalarga syncline (approximately 11 km wide) to the east. Detailed geologic surface mapping and subsurface seismic interpretation suggest that the formation and evolution of the Cibarco anticline have been strongly influenced by mud diapirism, which has been focused along a west-southwest–east-northeast-trending, inverted pre-Oligocene extensional fault. Seismic interpretation and outcrop analyses also confirmed that the source of mobile shales is the Upper Oligocene marlstones of the Lower Ciénaga de Oro Formation. We suggest that the main mechanism that caused the overpressures that triggered and controlled shale mobilization was disequilibrium compaction related to the sedimentary loading of impermeable seals and the shortening and inversion of pre-Oligocene extensional faults. Growth strata indicate that the Upper Oligocene mud started moving in Early Miocene times during the deposition of the thick Porquero mudstones, and it stopped migrating in Latest Miocene times. After an uplift and erosion event, mud diapirism remained inactive in the Early Miocene, and it was then reactivated in Late Pliocene times. Slight mud migration focused on the inverted fault continued throughout the Pleistocene and to the present. Today, the slight mud migration to the surface is observed in volcanoes located in the northern strand of the Cibarco anticline, although the rest of the anticline has become welded. Our new interpretations, carried out more than a century after the first hydrocarbon exploration activities began in Colombia, will hopefully allow us to increase our understanding of shale tectonics, petroleum systems, and plays in this portion of the convergent margin.
Seismic aberrancy unraveling basement flexures: A study from northeast India
Authors: Kumar Priyadarshi Chinmoy , Bedle Heather , Kumar Jitender , Sain Kalachand 
Published: August 2024

The basement in the Upper Assam foreland basin, northeast India, is severely deformed and buckled. It is compartmentalized into several structural compartments. These compartments are breached with minute flexures (or fractures), which developed over the geologic period due to tectonic modifications by fault networks and overlying sediment loads. Flexure anomalies dominant within the basement interval are interpreted using high-quality 3D seismic data acquired from the basin. The data are spectral balanced and structurally conditioned to improve the visibility of suppressed and masked reflections. Attribute maps obtained by computing legacy seismic attributes like energy ratio-similarity and curvature are integrated to interpret flexure networks and associated deformed structures. An advanced seismic attribute called aberrancy is computed to complement the interpretations of the preceding legacy attributes. The aberrancy attribute prominently revealed the presence of flexure networks occurring within the basement interval in the study area. In addition, the geometric characteristics of flexure anomalies suggest that flexures are particularly intense in the northeastern (zone 1) and western (zone 2) parts of the basement. The intensity of the flexures within these zones varies between 0.3 and 0.6 m−1. Overall, the basement displays a low to moderate variation in the intensity of the flexures, with exceptions observed in the aforementioned zones. The method thus presented could be applied to similar tectonic settings to aid the interpretation of subtle deformed networks observed in seismic data.
Lacrosse in the Economic and Social Life of the Kanien’kehá:ka Community of Kahnawà:ke in the Late Nineteenth Century
Authors: Reid Gerald F. 
Published: August 2024

Abstract
During the second half of the nineteenth century, the Kanien’kehá:ka community of Kahnawà:ke was strained by several intersecting economic, social, and political tensions. Drawing on recent scholarship and a variety of primary source materials, this article examines these tensions and considers lacrosse as a source of economic opportunity and social capital that enabled Kahnawa’kehró:non to cope with these strains and maintain the economic and social fabric of their community.
Global Sensitivity Analysis via Optimal Transport
Authors: Borgonovo Emanuele , Figalli Alessio , Plischke Elmar , Savaré Giuseppe 
Published: August 2024

We examine the construction of variable importance measures for multivariate responses using the theory of optimal transport. We start with the classical optimal transport formulation. We show that the resulting sensitivity indices are well-defined under input dependence, are equal to zero under statistical independence, and are maximal under fully functional dependence. Also, they satisfy a continuity property for information refinements. We show that the new indices encompass Wagner’s variance-based sensitivity measures. Moreover, they provide deeper insights into the effect of an input’s uncertainty, quantifying its impact on the output mean, variance, and higher-order moments. We then consider the entropic formulation of the optimal transport problem and show that the resulting global sensitivity measures satisfy the same properties, with the exception that, under statistical independence, they are minimal, but not necessarily equal to zero. We prove the consistency of a given-data estimation strategy and test the feasibility of algorithmic implementations based on alternative optimal transport solvers. Application to the assemble-to-order simulator reveals a significant difference in the key drivers of uncertainty between the case in which the quantity of interest is profit (univariate) or inventory (multivariate). The new importance measures contribute to meeting the increasing demand for methods that make black-box models more transparent to analysts and decision makers. This paper was accepted by Baris Ata, stochastic models and simulation. Funding: A. Figalli acknowledges the support of the ERC [Grant 721675] “Regularity and Stability in Partial Differential Equations (RSPDE)” and of the Lagrange Mathematics and Computation Research Center. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.01796 .