bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geography versus sociodemographics as predictors of changes in daily mobility across the USA during the COVID-19 pandemic: a two-stage regression analysis across 26 metropolitan areas
Authors: Schaber Kathryn , Arambepola Rohan , Schluth Catherine , Labrique Alain B , Mehta Shruti H , Solomon Sunil S , Cummings Derek A T , Wesolowski Amy 
Published: July 2024

ObjectiveWe investigated whether a zip code’s location or demographics are most predictive of changes in daily mobility throughout the course of the COVID-19 pandemic.DesignWe used a population-level study to examine the predictability of daily mobility during the COVID-19 pandemic using a two-stage regression approach, where generalised additive models (GAM) predicted mobility trends over time at a large spatial level, then the residuals were used to determine which factors (location, zip code-level features or number of non-pharmaceutical interventions (NPIs) in place) best predict the difference between a zip code’s measured mobility and the average trend on a given date.SettingWe analyse zip code-level mobile phone records from 26 metropolitan areas in the USA on 15 March–31 September 2020, relative to October 2020.ResultsWhile relative mobility had a general trend, a zip code’s city-level location significantly helped to predict its daily mobility patterns. This effect was time-dependent, with a city’s deviation from general mobility trends differing in both direction and magnitude throughout the course of 2020. The characteristics of a zip code further increased predictive power, with the densest zip codes closest to a city centre tended to have the largest decrease in mobility. However, the effect on mobility change varied by city and became less important over the course of the pandemic.ConclusionsThe location and characteristics of a zip code are important for determining changes in daily mobility patterns throughout the course of the COVID-19 pandemic. These results can determine the efficacy of NPI implementation on multiple spatial scales and inform policy makers on whether certain NPIs should be implemented or lifted during the ongoing COVID-19 pandemic and when preparing for future public health emergencies.
Shift in house price estimates during COVID-19 reveals effect of crisis on collective speculation
Authors: Petersen Alexander M. 
Published: July 2024

AbstractWe exploit a city-level panel comprised of individual house price estimates to estimate the impact of COVID-19 on both small and big real-estate markets in California USA. Descriptive analysis of spot house price estimates, including contemporaneous price uncertainty and 30-day price change for individual properties listed on the online real-estate platform Zillow.com, together facilitate quantifying both the excess valuation and valuation confidence attributable to this global socio-economic shock. Our quasi-experimental pre-/post-COVID-19 design spans several years around 2020 and leverages contemporaneous price estimates of rental properties – i.e., off-market real estate entering the habitation market, just not for purchase and hence free of speculation – as an appropriate counterfactual to properties listed for sale, which are subject to on-market speculation. Combining unit-level matching and multivariate difference-in-difference regression approaches, we obtain consistent estimates regarding the sign and magnitude of excess price growth observed after the pandemic onset. Specifically, our results indicate that properties listed for sale appreciated an additional 1% per month above what would be expected in the absence of the pandemic. This corresponds to an excess annual price growth of roughly 12.7 percentage points, which accounts for more than half of the actual annual price growth in 2021 observed across the studied regions. Simultaneously, uncertainty in price estimates decreased, signaling the irrational confidence characteristic of prior asset bubbles. We explore how these two trends are related to market size, local market supply and borrowing costs, which altogether lend support for the counterintuitive roles of uncertainty and interruptions in decision-making.
Kalanchoe steyniae (Crassulaceae subfam. Kalanchooideae; K. [subg. Kalanchoe sect. Raveta] ser. Rotundifoliae), a new, small-growing, shrubby species from eastern southern Africa
Authors: SMITH GIDEON F. , CROUCH NEIL R. 
Published: July 2024

A new species of Kalanchoe (K. [subg. Kalanchoe sect. Raveta] ser. Rotundifoliae; Crassulaceae subfam. Kalanchooideae), K. steyniae, is described from the northeastern parts of South Africa’s KwaZulu-Natal province and neighbouring Eswatini in eastern southern Africa. Kalanchoe steyniae differs from K. rotundifolia in especially reproductive characters, with, inter alia, its flowers being densely arranged (not diffusely so) in ± flat-topped, corymbose cymes; its corolla lobes showing weak (not distinct) diurnal movement; its sepals being longer; and its corolla tubes and corolla lobes being bright crimson red (not dull red to orange). Both species are illustrated.
Advanced Peak Phase of ENSO under Global Warming
Authors: Zheng Xiao-Tong , Hui Chang , Han Zi-Wen , Wu Yue 
Published: July 2024

Abstract
El Niño–Southern Oscillation (ENSO) is the leading mode of interannual ocean–atmosphere coupling in the tropical Pacific, greatly influencing the global climate system. Seasonal phase locking, which means that ENSO events usually peak in boreal winter, is a distinctive feature of ENSO. In model future projections, the ENSO sea surface temperature (SST) amplitude in winter shows no significant change with a large intermodel spread. However, whether and how ENSO phase locking will respond to global warming are not fully understood. In this study, using Community Earth System Model Large Ensemble (CESM-LE) projections, we found that the seasonality of ENSO events, especially its peak phase, has advanced under global warming. This phenomenon corresponds to the seasonal difference in the changes in the ENSO SST amplitude with an enhanced (weakened) amplitude from boreal summer to autumn (winter). Mixed layer ocean heat budget analysis revealed that the advanced ENSO seasonality is due to intensified positive meridional advective and thermocline feedback during the ENSO developing phase and intensified negative thermal damping during the ENSO peak phase. Furthermore, the seasonal variation in the mean El Niño–like SST warming in the tropical Pacific favors a weakened zonal advective feedback in boreal autumn–winter and earlier decay of ENSO. The advance of the ENSO peak phase is also found in most CMIP5/6 models that simulate the seasonal phase locking of ENSO well in the present climate. Thus, even though the amplitude response in the winter shows no model consensus, ENSO also significantly changes during different stages under global warming.
A phase 2 study of a longitudinal multidimensional rehabilitation program for allogeneic blood and marrow transplantation patients
Authors: Tam Samantha , Alibhai Shabbir M. H. , Hassanieh Dima , Kumar Rajat , Mattsson Jonas , Atenafu Eshetu G. , Avery Lisa , Bernstein Lori J. , Chang Eugene , Langelier David , Lopez Paty , Jones Jennifer M. 
Published: July 2024

Abstract
Allogeneic blood and marrow transplantation (alloBMT) is a curative treatment for blood cancers associated with various treatment-related adverse events and morbidities for which rehabilitation programs are currently limited. A phase 2 randomized controlled trial (RCT) was conducted to assess the feasibility, acceptability, and impact of CaRE-4-alloBMT, a longitudinal, multidimensional cancer rehabilitation program for patients undergoing alloBMT. The primary outcomes included the feasibility and acceptability of the intervention and the methods. Feasibility was assessed through recruitment, retention, and adherence rates. Acceptability was assessed through qualitative interviews. Secondary clinical outcomes were collected through questionnaires and physiological assessments at 4 time points. A total of 80 participants were recruited and randomized. Recruitment (72%) and retention (70%) rates, along with qualitative findings, support the feasibility of the intervention. Adherence was suboptimal, most notably educational module completion (22.7%). Treatment effect sizes of 0.70 (95% confidence interval [CI], 0.20-1.21; 30-second sit-to-stand test) and 0.46 (95% CI, –0.17 to 1.09; 36-Item Short Form Survey) were observed in favor of the intervention. The results appear promising; however, the findings are limited by missing data owing to attrition. Modifications will be required to refine the program and inform a phase 3 RCT. This trial was registered at www.ClinicalTrials.gov as #NCT04966156.
CD19-directed CART therapy for T-cell/histiocyte–rich large B-cell lymphoma
Authors: Pophali Priyanka A. , Fein Joshua A. , Ahn Kwang W. , Allbee-Johnson Molly , Ahmed Nausheen , Awan Farrukh T. , Farhan Shatha , Grover Natalie S. , Hilal Talal , Iqbal Madiha , Maakaron Joseph , Modi Dipenkumar , Nasrollahi Elham , Schachter Levanto G. , Sauter Craig , Hamadani Mehdi , Herrera Alex , Shouval Roni , Shadman Mazyar 
Published: July 2024

Abstract
T-cell/histiocyte–rich large B-cell lymphoma (THRLBCL) is a rare histologic variant of LBCL. Limited data regarding CD19–directed chimeric antigen receptor T-cell (CART) therapy in relapsed/refractory (R/R) THRLBCL suggest poor efficacy. We investigated CART outcomes for R/R THRLBCL through the Center for International Blood and Marrow Transplant Research registry. A total of 58 adult patients with R/R THRLBCL who received commercial CD19-CART therapy between 2018 and 2022 were identified. Most patients (67%) had early relapse of disease (45% primary refractory) with a median of 3 (range, 1-7) prior therapies and were treated with axicabtagene ciloleucel (69%). At median follow-up of 23 months after CART therapy, 2-year overall and progression-free survival were 42% (95% confidence interval [CI], 27-57) and 29% (95% CI, 17-43), respectively. In univariable analysis, poor performance status before CART therapy was associated with higher mortality (hazard ratio, 2.35; 95%CI, 1.02-5.5). The 2-year cumulative incidences of relapse/progression and nonrelapse mortality were 69% and 2%, respectively. Grade ≥3 cytokine release syndrome and immune effector cell–associated neurologic syndrome occurred in 7% and 15% of patients, respectively. In this largest analysis of CD19-CART therapy for R/R THRLBCL, ∼30% of patients were alive and progression free 2 years after CART therapy. Despite a high incidence of progression (69% at 2 years), these results suggest a subset of patients with R/R THRLBCL may have durable responses with CARTs.
Using high-density SNP data to unravel the origin of the Franches-Montagnes horse breed
Authors: Gmel Annik Imogen , Mikko Sofia , Ricard Anne , Velie Brandon D. , Gerber Vinzenz , Hamilton Natasha Anne , Neuditschko Markus 
Published: July 2024

Abstract
Background
The Franches-Montagnes (FM) is the last native horse breed of Switzerland, established at the end of the 19th century by cross-breeding local mares with Anglo-Norman stallions. We collected high-density SNP genotype data (Axiom™ 670 K Equine genotyping array) from 522 FM horses, including 44 old-type horses (OF), 514 European Warmblood horses (WB) from Sweden and Switzerland (including a stallion used for cross-breeding in 1990), 136 purebred Arabians (AR), 32 Shagya Arabians (SA), and 64 Thoroughbred (TB) horses, as introgressed WB stallions showed TB origin in their pedigrees. The aim of the study was to ascertain fine-scale population structures of the FM breed, including estimation of individual admixture levels and genomic inbreeding (FROH) by means of Runs of Homozygosity.

Results
To assess fine-scale population structures within the FM breed, we applied a three-step approach, which combined admixture, genetic contribution, and FROH of individuals into a high-resolution network visualization. Based on this approach, we were able to demonstrate that population substructures, as detected by model-based clustering, can be either associated with a different genetic origin or with the progeny of most influential sires. Within the FM breed, admixed horses explained most of the genetic variance of the current breeding population, while OF horses only accounted for a small proportion of the variance. Furthermore, we illustrated that FM horses showed high TB admixture levels and we identified inconsistencies in the origin of FM horses descending from the Arabian stallion Doktryner. With the exception of WB, FM horses were less inbred compared to the other breeds. However, the relatively few but long ROH segments suggested diversity loss in both FM subpopulations. Genes located in FM- and OF-specific ROH islands had known functions involved in conformation and behaviour, two traits that are highly valued by breeders.

Conclusions
The FM remains the last native Swiss breed, clearly distinguishable from other historically introgressed breeds, but it suffered bottlenecks due to intensive selection of stallions, restrictive mating choices based on arbitrary definitions of pure breeding, and selection of rare coat colours. To preserve the genetic diversity of FM horses, future conservation managements strategies should involve a well-balanced selection of stallions (e.g., by integrating OF stallions in the FM breeding population) and avoid selection for rare coat colours.
Implementation of remote general movement assessment using the in-motion instructions in a high-risk norwegian cohort
Authors: Adde Lars , Åberg Kristin Bjørnstad , Fjørtoft Toril , Grunewaldt Kristine Hermansen , Lade Randi , Osland Siril , Piegsa Frank , Sandstrøm Per Gunnar , Støen Ragnhild , Størvold Gunfrid V. , Eriksen Beate Horsberg 
Published: July 2024

Abstract
Background
General Movement Assessment (GMA) is recommended for early detection of risk for cerebral palsy but requires trained clinical experts. We aimed to implement home- and hospital-based filming for remote GMA in a Norwegian high-risk infant cohort, as well as evaluating parents’ experiences in filming their infant at home.

Methods
This knowledge translational study used a prospective cohort design including participants referred to neurodevelopmental follow-up across three sites in the Central Norway Regional Health Authority. Two home films of the fidgety type of general movements were collected between 12+1–14+6 and 15+1–17+6 weeks after term by parents. An additional film was collected at the hospital between 12+1 and 17+6 weeks after term. The instructional guide for all filming was the In-Motion App standards. Videos were transferred to a remote GMA team and classified as either “GMA scorable” or “GMA not scorable” based on Prechtl’s GMA standards. Parents responded to an online survey using a 5-point Likert scale to collect information about their perspectives, experiences, and possible worries by filming their infant at home.

Results
One-hundred-and-two infants from 95 families participated. Ninety-two (96.8%) families transferred 177 home-based videos. Eighty-four (92%) of these had 95 videos taken in their local hospital. All 177 home-videos were “GMA scorable” and three (3,1%) out of 95 hospital-based videos were classified as “GMA not scorable”. Eight families did not respond to the survey and two families did not receive the survey due to a technical error. Seventy-eight (91.7%) respondents agreed or strongly agreed that it was easy to perform home filming and five (5.9%) agreed that they were more worried about their child`s development after filming at home. Almost 80% of respondents agreed that a video for GMA can be taken at home instead of in hospital.

Conclusions
This study strengthens the clinical implementation of home filming by parents and remote GMA for early detection of CP in high-risk follow-up programs. The implementation of remote GMA has the potential to facilitate early intervention to improve function in children with CP in line with international recommendations.

Trial registration
ClinicalTrials.gov ID: NCT04287166 Date of registration: 27/02/2020.
Non-surgical vs. surgical treatment of distal radius fractures: a meta-analysis of randomized controlled trials
Authors: Zhu Chaohua , Wang Xue , Liu Mengchao , Liu Xiaohui , Chen Jia , Liu Guobin , Ji Gang 
Published: July 2024

Abstract
Purpose
To compare the clinical outcomes between nonsurgical and surgical treatment of distal radius fracture.

Methods
We performed a systematic literature search by using multiple databases, including Medline, PubMed, and Cochrane. All databases were searched from the earliest records through February 2023. The study compared nonsurgical versus surgical treatment of distal radius fractures and included only randomized controlled trials (RCTS).

Results
There were seventeen randomized controlled trials retrieved. A total of 1730 patients were included: 862 in the nonsurgical group and 868 in the surgical group. The results showed a significant reduction in DASH score with surgical treatment (WMD 3.98, 95% CI (2.00, 5.95), P < 0.001). And in grip strength (%), the results showed a significant improvement in surgical treatment compared with non-surgical treatment (WMD − 6.60, 95% CI (-11.61, -1.60), P = 0.01). There was significant difference in radial inclination, radial length, volar title, range of wrist pronation, range of wrist supination. However, no difference in radial deviation, ulnar deviation, ulnar variance, range of wrist extension and range of wrist flexion was observed.

Conclusions
The results of this meta-analysis suggest that some patients with surgical treatment of distal radius fractures not only improved the grip strength (%), decreased the DASH score, but also improved the range of wrist pronation and the range of wrist supination compared with nonsurgical treatment. Based on the present meta-analysis, we suggest that some patients with surgical treatment might be more effective in patients with distal radius fracture.
AI-initiated second opinions: a framework for advanced caries treatment planning
Authors: Dascalu Tudor , Ramezanzade Shaqayeq , Bakhshandeh Azam , Bjørndal Lars , Ibragimov Bulat 
Published: July 2024

AbstractIntegrating artificial intelligence (AI) into medical and dental applications can be challenging due to clinicians’ distrust of computer predictions and the potential risks associated with erroneous outputs. We introduce the idea of using AI to trigger second opinions in cases where there is a disagreement between the clinician and the algorithm. By keeping the AI prediction hidden throughout the diagnostic process, we minimize the risks associated with distrust and erroneous predictions, relying solely on human predictions. The experiment involved 3 experienced dentists, 25 dental students, and 290 patients treated for advanced caries across 6 centers. We developed an AI model to predict pulp status following advanced caries treatment. Clinicians were asked to perform the same prediction without the assistance of the AI model. The second opinion framework was tested in a 1000-trial simulation. The average F1-score of the clinicians increased significantly from 0.586 to 0.645.
Online vs. face-to-face interactive communication education using video materials among healthcare college students: a pilot non-randomized controlled study
Authors: Ichikura Kanako , Watanabe Kazuhiro , Moriya Rika , Chiba Hiroki , Inoue Akiomi , Arai Yumi , Shimazu Akihito , Fukase Yuko , Tagaya Hirokuni , Tsutsumi Akizumi 
Published: July 2024

Abstract
Background
This study aimed to examine whether online interactive communication education using video materials was as effective as face-to-face education among healthcare college students.

Methods
The participants were healthcare college students who were enrolled in study programs to obtain national medical licenses. They participated in lectures and exercises on healthcare communication, both online (n = 139) and face-to-face (n = 132). Listening skills, understanding, and confidence in healthcare communication were assessed using a self-assessed tool.

Results
From the two-way ANOVA result, the interaction effects between group (online, face-to-face) and time (Time 1, Time 2, Time 3) were not statistically significant. The main effect of time increased significantly from Time1 to Time 3 on understanding of communication with patients (Hedges’g = 0.51, 95%CI 0.27–0.75), confidence in communication with patients (g = 0.40, 95%CI 0.16–0.64), and confidence in clinical practice (g = 0.49, 95%CI 0.25, 0.73), while the score of listening skills had no significant change (Hedges’g = 0.09, 95%CI − 0.03 to 0.45).

Conclusions
The results show that online communication education with video materials and active exercises is as effective in improving students’ confidence as face-to-face. It will be necessary to modify the content of this educational program to improve skills as well as confidence in communication.

Trial registration
Not Applicable.
AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity
Authors: Jiang Yanke , Yue Yingzhe , Lu Chongchong , Latif Muhammad Zunair , Liu Haifeng , Wang Zhaoxu , Yin Ziyi , Li Yang , Ding Xinhua 
Published: July 2024

AbstractPre-mRNA splicing is a significant step for post-transcriptional modifications and functions in a wide range of physiological processes in plants. Human NHP2L binds to U4 snRNA during spliceosome assembly; it is involved in RNA splicing and mediates the development of human tumors. However, no ortholog has yet been identified in plants. Therefore, we report At4g12600 encoding the ortholog NHP2L protein, and AtSNU13 associates with the component of the spliceosome complex; the atsnu13 mutant showed compromised resistance in disease resistance, indicating that AtSNU13 is a positive regulator of plant immunity. Compared to wild-type plants, the atsnu13 mutation resulted in altered splicing patterns for defense-related genes and decreased expression of defense-related genes, such as RBOHD and ALD1. Further investigation shows that AtSNU13 promotes the interaction between U4/U6.U5 tri-snRNP-specific 27 K and the motif in target mRNAs to regulate the RNA splicing. Our study highlights the role of AtSNU13 in regulating plant immunity by affecting the pre-mRNA splicing of defense-related genes.