bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transesophageal echocardiography guidance for percutaneous closure of PFO and a new method to improve the diagnosis and safety during the procedures
Authors: Luo Limin , Xie Zehan , Wu Qiaoyan , Liu Qiang , Hou Huiping , Wang Yongshi , Shu Xianhong 
Published: July 2024

PurposePercutaneous patent foramen ovale (PFO) closure is becoming more and more common for the treatment or prevention of PFO-associated right-to-left shunt (RLS). This study aims to investigate the value of transesophageal echocardiography (TEE) in percutaneous PFO closure, and to explore a new method that can improve intraoperative diagnosis and surgical safety.Materials and methodsBased on our inclusion and exclusion criteria, we enrolled 73 patients between 16 and 70 years old (average age 43.25 ± 14.87 years) who underwent percutaneous PFO closure at the Department of Cardiac Surgery, Zhongshan Hospital (Xiamen), Fudan University, from January 2022 to December 2023. Out of the 73 enrolled patients, there were 28 males (38.36%) and 45 females (61.64%), 29 migraine patients (39.73%), 14 patients (19.19%) with headache and dizziness, 14 patients (19.18%) with a history of cerebral infarction (CI), and 25 patients (34.25%) with CI, lacunar infarction or ischemic focus on magnetic resonance imaging (MRI). All patients received routine transthoracic echocardiography (TTE) and agitated saline contrast echocardiography (ASCE) before operations. Percutaneous closure of PFO was completed under the guidance of TEE. In 12 patients, the method of “injection of heparinized sterile saline through the delivery sheath” was used to observe their RLS, and the anatomical characteristics of the PFO according to the shunt path were monitored and evaluated. This method was also applied to some patients to guide the conveyor to pass through the foramen ovale (FO) channel safely and effectively, thereby improving the success rate of PFO closure.ResultsThe application of TEE during the procedure of percutaneous PFO closure, including preoperative evaluation, intraoperative guidance, and postoperative reevaluation, can offer further details about the anatomical and shunt characteristics of PFO, improve the diagnosis rate, and confirm the safety of the surgical path. It ensures the safety and reliability of the whole operation, greatly improving the success rate and reducing postoperative complications.ConclusionsTEE guidance of percutaneous PFO closure has the advantages of minimal trauma, no radiation and real-time visualization, while injecting heparinized sterile saline through the delivery sheath is safer and more effective in improving the success rate and reducing postoperative complications.
Educational practices for the language development of students with intellectual developmental disorder in the school setting: a systematic review
Authors: Janho dit Hreich Céline , Ibernon Laure , Bourdin Béatrice 
Published: July 2024

BackgroundIntellectual development disorder (IDD) is a challenging disorder that professionals, most notably teachers, are confronted with daily. Supporting oral language in the classroom is a complex challenge as teachers are expected to implement effective methods to support students’ language. However, they face a persistent scarcity of scientific evidence to draw upon in their practice.AimsThis research provides a first overview of instructional methods and their effectiveness in this population.MethodOur search was conducted through various databases, generating a total of 931 articles. Data from the 14 selected studies were analyzed.Outcomes and resultsThe results reveal limited, heterogenous, and hardly comparable studies in terms of their characteristics (samples, language area, strategies, and effectiveness measures) suggesting a low level of evidence regarding the effectiveness of these practices.Conclusion and implicationsWe discuss the implications of these findings in light of the different factors contributing to the interventions’ effectiveness, as well as considering the issue of transfer and generalization of acquired skills in IDD. We also reveal the urgent need for developing methods addressing cognitive load limitations such as implicit learning approaches, to enhances effectiveness and compensate the gap of available resources tailored to improve oral language outcomes in the IDD population.
Transformer partial discharge location technology based on gradient oil temperature
Authors: Yu Ruidong , Zhang Zhousheng 
Published: July 2024

IntroductionThe traditional partial discharge localization improvement strategy mainly starts from the intelligent algorithm, but fails to consider the influence of core winding and oil temperature on partial discharge positioning.MethodsThis paper also considers the influence of the iron core winding and oil temperature. Through finite element simulation, a transformer model was established to analyze the propagation characteristics of ultrasonic signals generated by partial discharge under the interference of gradient oil temperature and winding. The chaotic firefly-particle swarm hybrid algorithm is proposed, and through the calculation of Shubert’s multi-peak function. Finally, a partial discharge defect platform based on gradient oil temperature was built to verify the chaotic firefly-particle swarm hybrid localization algorithm.ResultsThe ultrasonic velocity generated by partial discharge in transformers cannot be fixed, and it is suggested that ultrasonic sensors should be installed near the center of the top of the transformer. The proposed algorithm can be better optimized in the case of multiple local extreme points. Under gradient oil temperature experiments, the algorithm achieves positioning errors less than 100 and 55 mm for cases with and without winding obstruction, respectively, with average positioning errors of 74.2 and 35.2 mm.DiscussionThe positioning method in this paper can provide a technical reference for the partial discharge positioning of transformers in actual operation.
Expressions and clinical significance of CCN5 and E-cadherin in primary and recurrent lesions of breast cancer
Authors: Zhou Guofeng , Gui Xingxing , Qu Wei , Zhang Xiujuan 
Published: July 2024

BackgroundBreast cancer recurrence and lymph node metastasis significantly impact patient outcomes. Understanding the molecular mechanisms behind these processes is crucial for developing effective treatments. CCN5 and E-cadherin are proteins involved in cell adhesion and epithelial-mesenchymal transition (EMT), playing roles in breast cancer progression.ObjectiveThis study aimed to analyze the expression levels and clinical significance of CCN5 and E-cadherin in primary and recurrent breast cancer lesions.MethodsImmunohistochemical staining using the SP method was performed to detect CCN5 and E-cadherin expression levels in 28 normal breast tissue samples, 52 primary breast cancer lesions, and paired recurrent chest wall lesions. The expression levels of these proteins were compared across different tissue types and correlated with lymph node metastasis.ResultsCCN5 and E-cadherin expression levels significantly differed among normal breast tissues, primary breast cancer lesions, and recurrent lesions (Χ2 = 18.934 and Χ2 = 14.516, p &lt; 0.05). Primary breast cancer lesions exhibited higher CCN5 and E-cadherin expression levels compared with recurrent lesions and normal tissues, although these differences were not statistically significant. Patients without lymph node metastases exhibited significantly higher expression levels of CCN5 and E-cadherin compared with those with lymph node metastases (Χ2 = 9.775, Χ2 = 9.1479, p &lt; 0.05). A positive correlation between CCN5 and E-cadherin expression levels was found in breast cancer tissues (r = 0.398, p &lt; 0.001).ConclusionCCN5 and E-cadherin were expressed at lower levels in recurrent breast cancer tissues and those with lymph node metastases, indicating their potential roles in breast cancer recurrence and metastasis. These findings suggest that CCN5 and E-cadherin might work synergistically to influence breast cancer progression.
Predicting novel biomarkers for early diagnosis and dynamic severity monitoring of human ulcerative colitis
Authors: Chen Yu , Chen Li , Huang Sheng , Yang Li , Wang Li , Yang Feiyun , Huang Jinxiu , Ding Xiuliang 
Published: July 2024

BackgroundUlcerative colitis is an emerging global health concern that poses a significant threat to human health and can progress to colorectal cancer if not diagnosed and treated promptly. Currently, the biomarkers used clinically for diagnosis and dynamic severity monitoring lack disease specificity.MethodsMouse models induced with 2%, 2.5%, and 3% DSS were utilized to simulate human UC with varying severities of inflammation. Transcriptome sequencing technology was employed to identify differentially expressed genes (DEGs) between the control group and each treatment group. Functional enrichment analysis of the KEGG database was performed for shared DEGs among the three treatment groups. DEGs that were significantly and strongly correlated with DSS concentrations were identified using Spearman correlation analysis. Human homologous genes of the interested DEGs were searched in the HomoloGene database, and their regulation patterns in UC patients were validated using the GSE224758 dataset. These genes were then submitted to the DisGeNET database to identify their known associations with human diseases. Online tools, including SignalP 6.0 and DeepTMHMM 1.0, were used to predict signal peptides and transmembrane helices in the amino acid sequences of human genes homologous to the DEGs of interest.ResultsA total of 1,230, 995, and 2,214 DEGs were identified in the 2%, 2.5%, and 3% DSS-induced groups, respectively, with 668 DEGs common across all three groups. These shared DEGs were primarily associated with signaling transport, pathogenesis, and immune response. Through extensive screening, LGI2 and PRSS22 were identified as potentially novel biomarkers with higher specificity and ease of detection for the early diagnosis and dynamic severity monitoring of human UC, respectively.ConclusionWe have identified two potentially novel biomarkers, LGI2 and PRSS22, which are easy of detection and more specific for human UC. These findings provide new insights into the accurate diagnosis and dynamic monitoring of this persistent disease.
Identification and validation of tryptophan-related gene signatures to predict prognosis and immunotherapy response in lung adenocarcinoma reveals a critical role for PTTG1
Authors: Wang Ziqiang , Zhang Jing , Zuo Chao , Chen Huili , Wang Luyao , Xie Yiluo , Ma Hongyu , Min Shengping , Wang Xiaojing , Lian Chaoqun 
Published: July 2024

IntroductionTryptophan metabolism is strongly associated with immunosuppression and may influence lung adenocarcinoma prognosis as well as tumor microenvironment alterations.MethodsSequencing datasets were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Two different clusters were identified by consensus clustering, and prognostic models were established based on differentially expressed genes (DEGs) in the two clusters. We investigated differences in mutational landscapes, enrichment pathways, immune cell infiltration, and immunotherapy between high- and low-risk scoring groups. Single-cell sequencing data from Bischoff et al. were used to identify and quantify tryptophan metabolism, and model genes were comprehensively analyzed. Finally, PTTG1 was analyzed at the pan-cancer level by the pan-TCGA cohort.ResultsRisk score was defined as an independent prognostic factor for lung adenocarcinoma and was effective in predicting immunotherapy response in patients with lung adenocarcinoma. PTTG1 is one of the key genes, and knockdown of PTTG1 in vitro decreases lung adenocarcinoma cell proliferation and migration and promotes apoptosis and down-regulation of tryptophan metabolism regulators in lung adenocarcinoma cells.DiscussionOur study revealed the pattern and molecular features of tryptophan metabolism in lung adenocarcinoma patients, established a model of tryptophan metabolism-associated lung adenocarcinoma prognosis, and explored the roles of PTTG1 in lung adenocarcinoma progression, EMT process, and tryptophan metabolism.
Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization
Authors: Li Beining , Hu Ping , Liang Hongyan , Zhao Xingliang , Zhang Aiting , Xu Yingchong , Zhang Bin , Zhang Jie 
Published: July 2024

ObjectiveThis study sought to identify circulating proteins causally linked to Inflammatory Bowel Disease (IBD) traits through a Mendelian Randomization (MR) analytical framework.MethodsUsing a large-scale, two-sample MR approach, we estimated the genetic links of numerous plasma proteins with IBD and its subtypes, leveraging information from the Inflammatory Bowel Disease Genetics Consortium. To assess the robustness of MR findings, methods like Bayesian colocalization, and Steiger filtering analysis, evaluation of protein-altering variants. Further insights into IBD’s underlying mechanisms and therapeutic targets were gleaned from single-cell sequencing analyses, protein-protein interaction assessments, pathway enrichment analyses, and evaluation of drug targets.ResultsBy cis-only MR analysis, we identified 83 protein-phenotype associations involving 27 different proteins associated with at least one IBD subtype. Among these proteins, DAG1, IL10, IL12B, IL23R, MST1, STAT3 and TNFRSF6B showed overlapping positive or negative associations in all IBD phenotypes. Extending to cis + trans MR analysis, we further identified 117 protein-feature associations, including 44 unique proteins, most of which were not detected in the cis-only analysis. In addition, by performing co-localization analysis and Steiger filtering analysis on the prioritized associations, we further confirmed the causal relationship between these proteins and the IBD phenotype and verified the exact causal direction from the protein to the IBD-related feature.ConclusionMR analysis facilitated the identification of numerous circulating proteins associated with IBD traits, unveiling protein-mediated mechanisms and promising therapeutic targets.
A clinical-radiomics nomogram for the prediction of the risk of upper gastrointestinal bleeding in patients with decompensated cirrhosis
Authors: Li Zhichun , He Qian , Yang Xiao , Zhu Tingting , Li Xinghui , Lei Yan , Tang Wei , Peng Song 
Published: July 2024

ObjectiveTo develop a model that integrates radiomics features and clinical factors to predict upper gastrointestinal bleeding (UGIB) in patients with decompensated cirrhosis.Methods104 decompensated cirrhosis patients with UGIB and 104 decompensated cirrhosis patients without UGIB were randomized according to a 7:3 ratio into a training cohort (n = 145) and a validation cohort (n = 63). Radiomics features of the abdominal skeletal muscle area (SMA) were extracted from the cross-sectional image at the largest level of the third lumbar vertebrae (L3) on the abdominal unenhanced multi-detector computer tomography (MDCT) images. Clinical-radiomics nomogram were constructed by combining a radiomics signature (Rad score) with clinical independent risk factors associated with UGIB. Nomogram performance was evaluated in calibration, discrimination, and clinical utility.ResultsThe radiomics signature was built using 11 features. Plasma prothrombin time (PT), sarcopenia, and Rad score were independent predictors of the risk of UGIB in patients with decompensated cirrhosis. The clinical-radiomics nomogram performed well in both the training cohort (AUC, 0.902; 95% CI, 0.850–0.954) and the validation cohort (AUC, 0.858; 95% CI, 0.762–0.953) compared with the clinical factor model and the radiomics model and displayed excellent calibration in the training cohort. Decision curve analysis (DCA) demonstrated that the predictive efficacy of the clinical-radiomics nomogram model was superior to that of the clinical and radiomics model.ConclusionClinical-radiomics nomogram that combines clinical factors and radiomics features has demonstrated favorable predictive effects in predicting the occurrence of UGIB in patients with decompensated cirrhosis. This helps in early diagnosis and treatment of the disease, warranting further exploration and research.
Assessing the role and impact of research in clinical practice among acupuncturists in western countries: a multinational cross-sectional survey
Authors: Huemer Matthias , Graca Sandro , Bitsche Sarah , Hofmann Guenter , Armour Mike , Pichler Martin 
Published: July 2024

BackgroundEvidence-informed practice is crucial to perform safe and efficient health interventions. In recent years, the evidence base of acupuncture continuously increased leading to the integration of acupuncture into clinical guidelines by various leading medical associations worldwide. At the same time, recent studies showed that licensed acupuncturists are rarely utilizing scientific research to inform their practice.MethodsThis descriptive study using an online survey assessed the role of evidence-informed practice of acupuncturists in Austria, Germany, the United States of America, Australia, and New Zealand and aimed to determine critical factors relevant for promoting research literacy including demographical data, data about the clinical practice patterns, and the role and value of different information sources of traditional, complementary and integrative medicine (TCIM) practitioners.ResultsIn total, 404 acupuncturists completed the online survey that included questions about demographic characteristics, the role and value of research in clinical practice, and details about the amount and type of continuing professional education. Univariate and multivariate analysis was used to determine significant predictors of the outcome variable “importance of research in clinical practice” (numerical rating scale, 0 to 100). The results showed that the majority of acupuncturists use certified courses as primary source of continuing professional education and value experts’ opinions as the most reliable source of information. Multivariate analysis showed that the importance of research is dependent on the interest in research, an interdisciplinary learning environment, and positive experiences with research including if an acupuncture study ever changed the clinical practice of practitioners.ConclusionFuture educational programs should therefore focus on an interactive format aiming to promote skills to critically assess the value and practical use of research studies to improve the general practice of acupuncture.
The efficacy and safety of anti-vascular endothelial growth factor combined with Ahmed glaucoma valve implantation in the treatment of neovascular glaucoma: a systematic review and meta-analysis
Authors: He Chang-Zhu , Lu Song-Jie , Zeng Zhao-Jun , Liu Jun-Qiao , Qiu Qin , Xue Fu-Li , He Yu 
Published: July 2024

BackgroundThe intraocular injections of anti-vascular endothelial growth factor (anti-VEGF) demonstrates significant efficacy in inhibiting the formation of ocular neovascularization in neovascular glaucoma (NVG). Ahmed glaucoma valve implantation (AGVI) is extensively employed for the management of diverse glaucoma types.ObjectiveTo further evaluate the efficacy and safety of anti-VEGF combined with AGVI in the treatment of neovascular glaucoma.MethodsA thorough search for randomized controlled trials (RCTs) was conducted across eight databases: PubMed, EMBASE, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang, SinoMed, and VIP. The search period was set from the inception of each database until March 2, 2024, to identify RCTs investigating the effectiveness and safety of combining AGVI with anti-VEGF therapy for NVG. We used the Cochrane Risk of Bias Assessment Tool to evaluate the quality of the literature and performed statistical analysis using Stata 15.0 software.ResultsFourteen RCTs were included in this study. Compared with AGVI alone, the combination of anti-VEGF drugs and AGVI can reduce postoperative intraocular pressure (IOP) at 1 week [WMD = −4.03, 95% CI (−5.73, −2.34), p &lt; 0.001], 1 month [WMD = −5.39, 95% CI (−7.05, −3.74), p &lt; 0.001], 3 months [WMD = −6.59, 95% CI (−7.85, −5.32), p &lt; 0.001], 6 months [WMD = −4.99, 95% CI (−9.56, −0.43), p = 0.032], and more than 12 months [WMD = −3.86, 95% CI (−6.82, −0.90), p = 0.011], with a higher Effective rate [RR = 1.27, 95% CI (1.18, 1.37), p &lt; 0.001], decreased incidence of postoperative hyphema [RR = 0.24, 95% CI (0.15, 0.39), p &lt; 0.001], reduced use of postoperative antiglaucoma medications [WMD = −0.48, 95% CI (−0.61, −0.35), p &lt; 0.001], and decreased aqueous humor VEGF levels [SMD = −2.84, 95% CI (−4.37, −1.31), p &lt; 0.001].ConclusionIn comparison to AGVI alone, the combination of AGVI with anti-VEGF therapy has better effects in reducing IOP at various time intervals, diminishing postoperative antiglaucoma medication requirements and reducing aqueous humor VEGF levels. Furthermore, it effectively minimizes the incidence of postoperative hyphema. Nevertheless, due to the variability in the quality of the trials included, further high-quality experiments will be required in the future to substantiate this conclusion.Systematic review registrationPROSPERO, identifier CRD42024519862, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024519862.
Shared decision-making implementation status among dermatologists engaging in medical esthetics: a cross-sectional study in China
Authors: Li Shiyuan , Fan Jing , Qiang Yan , Duan Zhen , Wang Ruiping 
Published: July 2024

ObjectiveShared decision-making (SDM) is a collaborative process in which patients and healthcare providers jointly make a medical decision. This cross-sectional study aimed to identify the implementation status of shared decision-making among dermatologists engaging in medical esthetics in China and to identify factors associated with the good practice of SDM among them.MethodsFrom January to June 2023, a total of 1,287 dermatologists engaging in medical esthetics in China were recruited and completed the online interviews about their implementation of SDM based on the Shared Decision-Making Questionnaire for Doctors (SDM-Q-Doc). Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (CI) to explore factors associated with the higher SDM score achievement among dermatologists with medical esthetic practice.ResultsThe median value of the total SDM score was 39, and 48% (621/1278) of dermatologists with medical esthetic practice achieved at least 40 out of 45 scores. Logistic regression indicated that dermatologists aged 40–49 or ≥ 50 years and those engaging in medical esthetic practice for ≥5 years were more likely to achieve at least 40 out of 45 scores compared to dermatologists aged &lt;30 years with less than 5 years of medical esthetic practice. The ORs were 1.82 (95% CI: 1.13–3.12), 1.94 (95% CI: 1.13–3.61), and 1.76 (95% CI: 1.34–2.31), respectively.ConclusionThe SDM implementation level among Chinese dermatologists engaging in medical esthetics is high, especially for those who are older age and have more years of practice. Hence, it is highly recommended to promote and enhance SDM practice among younger dermatologists engaging in medical esthetics with less working experience.