bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layer‐Engineered Functional Multilayer Thin‐Film Structures and Interfaces through Atomic and Molecular Layer Deposition
Authors: Heikkinen Mari , Ghiyasi Ramin , Karppinen Maarit 
Published: June 2024

AbstractAtomic layer deposition (ALD) technology is one of the cornerstones of the modern microelectronics industry, where it is exploited in the fabrication of high‐quality inorganic thin films with excellent precision for film thickness and conformality. Molecular layer deposition (MLD) is a counterpart of ALD for purely organic thin films. Both ALD and MLD rely on self‐limiting gas‐surface reactions of vaporized and sequentially pulsed precursors and are thus modular, meaning that different precursor pulsing cycles can be combined in an arbitrary manner for the growth of elaborated superstructures. This allows the fusion of different building blocks — either inorganic or organic — even with contradicting properties into a single thin‐film material, to realize unforeseen material functions which can ultimately lead to novel application areas. Most importantly, many of these precisely layer‐engineered materials with attractive interfacial properties are inaccessible to other synthesis/fabrication routes. In this review, the intention is to present the current state of research in the field by i) summarizing the ALD and MLD processes so far developed for the multilayer thin films, ii) highlighting the most intriguing material properties and potential application areas of these unique layer‐engineered materials, and iii) outlining the future perspectives for this approach.
Iodine Mediated Annulation of Triethylamine, Aldehydes and 2‐Aminopyridines for the Synthesis of 3‐Formyl‐Imidazo [1,2‐a]pyridine Derivatives
Authors: Zhang Wenqing , Shen Lihong , Zhang Jun 
Published: June 2024

AbstractWith triethylamine as a synthon, an alternative method for the synthesis of 3‐formyl imidazo[1,2‐a]pyridines has been accomplished from aldehydes, and 2‐aminopyridines. The reaction proceeded via iodine‐catalyzed C−N bond cleavage of triethylamine, generation of α,β‐unsaturated aldehyde in situ, and oxidative cyclization with air as the oxygen source. This protocol may facilitate the synthesis of imidazo[1,2‐a]pyridine derivatives and provide a reference for the usage of triethylamine as a synthon.
Secondary Coordination Sphere Engineering of Single‐Sn‐Atom catalyst via P Doping for Efficient CO2 Electroreduction
Authors: Yue Caizhen , Yang Xiaobo , Zhang Xiong , Wang Shifu , Xu Wei , Chen Ruru , Wang Jiuyi , Yin Jie , Huang Yanqiang , Li Xuning 
Published: June 2024

AbstractThe regulation of the local microenvironment in the single‐atom catalysts affords a scheme for accelerating the overall reaction kinetics of electrochemical CO2 reduction reaction (CO2RR), which is of vital importance but remains challenging. Herein, a carbon nanotube‐supported single‐Sn‐atom catalyst (P‐SnN4‐CNT) is developed by a modified pyrolysis procedure with P‐doping into the second coordination shell of SnN4 moiety to modulate the electron structure of metal Sn center. The resulting P‐SnN4‐CNT delivered a high CO partial current density of −380 mA cm−2 with Faradaic efficiency (FE) of CO above 90% across a wide range of −0.5 to −0.8 V versus reversible hydrogen electrode (vs RHE), along with optimal FE (CO) of ≈98.5% at −0.6 V versus RHE in a flow cell. Moreover, P‐SnN4‐CNT achieved an extremely high turnover frequency of 126 471 h−1 with an applied potential of −0.8 V versus RHE, which ranks the best among the reported M─N─C catalysts for electrocatalytic CO2 reduction. The combination of in situ characterization techniques and density functional theory calculation revealed that the doping of P atoms benefited the activation and hydrogenation steps of CO2 and promoted the Sn4+ reduction to Sn2+ during the reaction process, where Sn2+ is identified as the active site for the CO generation. The work provides a clear mechanistic insight for both electron structure optimization and identification of active sites by local microenvironment regulation of single‐Sn‐atom, which shall pave a way for the exploitation of other M─N─C catalysts with high CO2RR performance.
Spontaneous Reaction of Electrocatalyst Resulted in a NH3 Faraday Efficiency of More than 100% in Electrochemical Nitrate Reduction
Authors: Yu Wanqiang , Chen Lili , Tan Hua , Huang Man , Yu Jiayuan , Wang Yujie , Wang Jingang , Liu Hong , Zhou Weijia 
Published: June 2024

AbstractAmmonia is emerging as a liquefied and renewable‐energy carrier of global interest in the future. The electrochemical reduction of nitrate is widely acknowledged as an alternative to the traditional Haber–Bosch process for ammonia production. However, it is observed that certain catalysts can undergo spontaneous oxidation–reduction reactions with nitrate to some extent, leading to the calculated ammonia Faradaic efficiency exceeding 100%. However, there is a lack of accurate experimental validation as well as effective solutions. To address these problems, it is verified that the spontaneous reaction between the catalyst and nitrate impacts on the calculation of electrocatalytic nitrate reduction performance. Meanwhile, an updated and optimized experimental strategy is proposed to address the interference caused by the spontaneous reaction. This work will significantly contribute to more accurate and reliable electrocatalytic nitrate reduction research.
Are all meats substitutes? A basket‐and‐expenditure‐based approach
Authors: Neill Clinton L. , Britton Logan L. 
Published: June 2024

AbstractThis study examines the relationship among animal‐based meat and plant‐based meat alternatives (PBMAs) using a basket‐and‐expenditure‐based choice experiment. In particular, we examine whether animal‐based meat products are substitutes or complements with PBMAs. Further, we incorporate consumer beliefs about their diet and environmental attitudes into the analysis. What we find is that PBMAs are not substitutes but rather complements or independent from one another. We also find that environmental and diet beliefs positively contribute to consumer utility for plant‐based alternatives. This study also demonstrates the strength of a basket‐based approach to examining complex consumer choices that require both discrete and continuous decisions in food purchasing.
Plasma amyloid beta X‐42/X‐40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease
Authors: Vogelgsang Jonathan , Hansen Niels , Stark Melina , Wagner Michael , Klafki Hans , Morgado Barbara Marcos , Jahn‐Brodmann Anke , Schott Björn , Esselmann Hermann , Bauer Chris , Schuchhardt Johannes , Kleineidam Luca , Wolfsgruber Steffen , Peters Oliver , Schneider Luisa‐Sophie , Wang Xiao , Menne Felix , Priller Josef , Spruth Eike , Altenstein Slawek , Lohse Andrea , Schneider Anja , Fliessbach Klaus , Vogt Ina , Bartels Claudia , Jessen Frank , Rostamzadeh Ayda , Duezel Emrah , Glanz Wenzel , Incesoy Enise , Butryn Michaela , Buerger Katharina , Janowitz Daniel , Ewers Michael , Perneczky Robert , Rauchmann Boris , Guersel Selim , Teipel Stefan , Kilimann Ingo , Goerss Doreen , Laske Christoph , Munk Matthias , Sanzenbacher Carolin , Spottke Annika , Roy‐Kluth Nina , Heneka Michael , Brosseron Frederic , Ramierez Alfredo , Schmid Matthias , Wiltfang Jens 
Published: June 2024

AbstractINTRODUCTIONBlood‐based biomarkers are a cost‐effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation‐immunoassay (IP‐IA) as a test for predicting cognitive decline.METHODSWe measured levels of amyloid beta (Aβ)X‐40 and AβX‐42 in immunoprecipitated eluates from the DELCODE cohort. Receiver‐operating characteristic (ROC) curves, regression analyses, and Cox proportional hazard regression models were constructed to predict AP by Aβ42/40 classification in cerebrospinal fluid (CSF) and conversion to mild cognitive impairment (MCI) or dementia.RESULTSWe detected a significant correlation between AßX‐42/X‐40 in plasma and CSF (r = 0.473). Mixed‐modeling analysis revealed a substantial prediction of AßX‐42/X‐40 with an area under the curve (AUC) of 0.81 for AP (sensitivity: 0.79, specificity: 0.74, positive predictive value [PPV]: 0.71, negative predictive value [NPV]: 0.81). In addition, lower AβX‐42/X‐40 ratios were associated with negative PACC5 slopes, suggesting cognitive decline.DISCUSSIONOur results suggest that assessing the plasma AβX‐42/X‐40 ratio via our semiautomated IP‐IA is a promising biomarker when examining patients with early or preclinical AD.Highlights
New plasma Aβ42/Aβ40 measurement using immunoprecipitation–immunoassay
Plasma Aβ42/Aβ40 associated with longitudinal cognitive decline
Promising biomarker to detect subjective cognitive decline at‐risk for brain amyloid positivity
The timing of death in burn patients
Authors: Yoneda Kazuhiro , Osuka Akinori , Ohnishi Shinya , Matsuura Hiroshi , Oda Jun 
Published: June 2024

AbstractAimWhen treating burn patients, some patients die in the chronic phase, even if they overcome the acute phase of the burn. To elucidate the timing of death and its underlying causes among burn patients.MethodsPatients evaluated were admitted to our burn center between January 2015, and December 2019. Patient information, time, and cause of death were retrospectively collected from their medical records.ResultsAmong 342 admitted patients, 49 died. The time of death was as follows: within 24 h (n = 9), within 3 days (n = 7), within 1 week (n = 5), within 2 weeks (n = 4), within 3 weeks (n = 3), within 30 days (n = 6), within 60 days (n = 5), and after 60 days (n = 9). The causes of death within 3 days were hypoxic encephalopathy, extensive burns (>80%), severe heat stroke, and acute coronary syndrome. The causes of death after 3 days were sepsis, pneumonia, intestinal ischemia, pancreatitis, and worsening of chronic diseases. The mortality rate was similar for patients ≥65 years of age and those with a burn area of ≥20%, with both groups showing a particularly poor prognosis.ConclusionsThe timing of death in hospitalized burn patients showed a bimodal distribution as approximately 40% of patients who survived the resuscitation period died after 30 days. Elderly patients were at particularly high risk for mortality. In burn care, treatment planning should consider not only the short‐term but also the long‐term prognosis.
Ionic Liquid‐Accelerated Growth of Covalent Organic Frameworks with Tunable Layer‐Stacking
Authors: Deng Lifeng , Zhu Sihao , Zou Qingyang , Xie Qiujian , Song Guangjie , Pan Chunyue , Wei Baosheng , Huang Zhehao , Liu Tianren , Tang Juntao , Yuan Jiayin , Yu Guipeng 
Published: June 2024

AbstractLayer‐stacking behaviors are crucial for two‐dimensional covalent organic frameworks (2D COFs) to define their pore structure, physicochemical properties, and functional output. So far, fine control over the stacking mode without complex procedures remains a grand challenge. Herein, we proposed a “key‐cylinder lock mimic” strategy to synthesize 2D COFs with a tunable layer‐stacking mode by taking advantage of ionic liquids (ILs). The staggered (AB) stacking (unlocked) COFs were exclusively obtained by incorporating ILs of symmetric polarity and matching molecular size; otherwise, commonly reported eclipsed (AA) stacking (locked) COFs were observed instead. Mechanistic study revealed that AB stacking was induced by a confined interlocking effect (CIE) brought by anions and bulky cations of the ILs inside pores (“key” and “cylinder”, respectively). Excitingly, this strategy can speed up production rate of crystalline powders (e.g., COF‐TAPT‐Tf@BmimTf2N in merely 30 minutes) under mild reaction conditions. This work highlights the enabling role of ILs to tailor the layer stacking of 2D COFs and promotes further exploration of their stacking mode‐dependant applications.
Photocatalytic CO2 Reduction by Near‐Infrared‐Light (1200 nm) Irradiation and a Ruthenium‐Intercalated NiAl‐Layered Double Hydroxide
Authors: Li Shaoquan , Li Zixian , Yue Jianing , Wang Huijuan , Wang Yujun , Su Wenli , Waterhouse Geoffrey I. N. , Liu Lihong , Zhang Wenkai , Zhao Yufei 
Published: June 2024

AbstractNear‐infrared light‐driven photocatalytic CO2 reduction (NIR‐CO2PR) holds tremendous promise for the production of valuable commodity chemicals and fuels. However, designing photocatalysts capable of reducing CO2 with low energy NIR photons remains challenging. Herein, a novel NIR‐driven photocatalyst comprising an anionic Ru complex intercalated between NiAl‐layered double hydroxide nanosheets (NiAl‐Ru‐LDH) is shown to deliver efficient CO2 photoreduction (0.887 μmol h−1) with CO selectivity of 84.81 % under 1200 nm illumination and excellent stability over 50 testing cycles. This remarkable performance results from the intercalated Ru complex lowering the LDH band gap (0.98 eV) via a compression‐related charge redistribution phenomenon. Furthermore, transient absorption spectroscopy data verified light‐induced electron transfer from the Ru complex towards the LDH sheets, increasing the availability of electrons to drive CO2PR. The presence of hydroxyl defects in the LDH sheets promotes the adsorption of CO2 molecules and lowers the energy barriers for NIR‐CO2PR to CO. To our knowledge, this is one of the first reports of NIR‐CO2PR at wavelengths up to 1200 nm in LDH‐based photocatalyst systems.
Two RNA Folds from One Sequence: A Ribozyme with Versatile Substrate Processing Abilities
Authors: Zhu Jikang , Dierks Dorothea , Möller Christina , Balke Darko , Müller Sabine 
Published: June 2024

AbstractWe report the design of a single RNA sequence capable of adopting one of two ribozyme folds and catalyzing the cleavage and/or ligation of the respective substrates. The RNA is able to change its conformation in response to its environment, hence it is called chameleon ribozyme (CHR). Efficient RNA cleavage of two different substrates as well as RNA ligation by CHR is demonstrated in separate experiments and in a one pot reaction. Our study shows that sequence variants of the hairpin ribozyme intersect with the hammerhead ribozyme and that rather short RNA molecules can have comprehensive conformational flexibility, which is an important feature for the emergence of new functional folds in early evolution.
A Renal Clearable Nano‐Assembly with Förster Resonance Energy Transfer Amplified Superoxide Radical and Heat Generation to Overcome Hypoxia Resistance in Phototherapeutics
Authors: Zhao Yuan‐Yuan , Zhang Xiaojun , Xu Yihui , Chen Zixuan , Hwang Bokyeong , Kim Heejeong , Liu Hao , Li Xingshu , Yoon Juyoung 
Published: June 2024

AbstractGiven that type I photosensitizers (PSs) possess a good hypoxic tolerance, developing an innovative tactic to construct type I PSs is crucially important, but remains a challenge. Herein, we present a smart molecular design strategy based on the Förster resonance energy transfer (FRET) mechanism to develop a type I photodynamic therapy (PDT) agent with an encouraging amplification effect for accurate hypoxic tumor therapy. Of note, benefiting from the FRET effect, the obtained nanostructured type I PDT agent (NanoPcSZ) with boosted light‐harvesting ability not only amplifies superoxide radical (O2•‐) production but also promotes heat generation upon near‐infrared light irradiation. These features facilitate NanoPcSZ to realize excellent phototherapeutic response under both normal and hypoxic environments. As a result, both in vitro and in vivo experiments achieved a remarkable improvement in therapeutic efficacy via the combined effect of photothermal action and type I photoreaction. Notably, NanoPcSZ can be eliminated from organs (including the liver, lung, spleen, and kidney) apart from the tumor site and excreted through urine within 24 h of its systemic administration. In this way, the potential biotoxicity of drug accumulation can be avoided and the biosafety can be further enhanced.
Parent–infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3‐year clinical outcome
Authors: Papageorgopoulou Eirini , Jones Emily J. H. , Johnson Mark H. , Charman Tony , Green Jonathan , Wan Ming Wai ,   The BASIS‐STAARS Team
Published: June 2024

AbstractDevelopmental antecedents of autism may affect parent–infant interactions (PII), altering the context in which core social skills develop. While studies have identified differences in PII between infants with and without elevated likelihood (EL) for autism, samples have been small. Here, we examined whether previously reported differences are replicable. From a longitudinal study of 113 EL and 27 typical likelihood infants (TL), 6‐min videotaped unstructured PII was blind rated at 8 and 14 months on eight interactional qualities. Autism outcome was assessed at 36 months. Linear mixed‐effects models found higher parent sensitive responsiveness, nondirectiveness, and mutuality ratings in TL than EL infants with and without later autism. PII qualities at 8 (infant positive affect, parent directiveness) and 14 months (infant attentiveness to parent, mutuality) predicted 3‐year autism. Attentiveness to parent decreased between 8 and 14 months in EL infants with later autism. This larger study supports previous findings of emerging alterations in PII in this group and extends on this by detecting earlier (8‐month) predictive effects of PII for autism outcome and a more marked trajectory of decreased social attentiveness. The findings strengthen the evidence base to support the implementation of early preemptive interventions to support PII in infants with early autism signs.
From home to boardroom: Marital status and its influence on ESG disclosure
Authors: Al Amosh Hamzeh 
Published: June 2024

AbstractThis research article investigates the relationship between the marital status of board members and organizations' environmental, social, and governance (ESG) disclosure, with Jordan as the study context. The investigation, grounded in established governance theories, primarily agency theory, stewardship theory, and social identity theory, adds a novel dimension to the discourse on corporate governance perspective. The study sample included 81 nonfinancial companies listed on the Amman stoke exchange from 2012 to 2021. The findings disclose a pronounced positive relationship between married board members and ESG disclosure separately and collectively, pointing to a normative commitment emanating from their personal lives that extends into their roles as corporate stewards, influencing corporate sustainability, and ethical governance. Conversely, the results did not indicate a relationship between single board members and ESG disclosure. The study underscores the importance of considering the personal attributes of board members in shaping corporate governance and ESG practices. Also, it encourages a broader perspective on how diverse personal backgrounds can enhance sustainability and ethical values within organizations by advocating for boards that reflect diverse marital statuses and a commitment to family values, benefitting not only shareholders but also society at large.
Sustainable transformation: An interaction of green entrepreneurship, green innovation, and green absorptive capacity to redefine green competitive advantage
Authors: Shehzad Muhammad Usman , Jianhua Zhang , Naveed Khwaja , Zia Umair , Sherani Mrs 
Published: June 2024

AbstractThis study examines the moderated mediation model grounded in the natural resource‐based view (NRBV) theory, evaluating the influence of green entrepreneurial orientation (GEO) on green competitive advantage (GCA) in Pakistani manufacturing firms. It emphasises the mediating role of green innovation (GI) and the conditional impact of green absorptive capacity (GAC). The study used hierarchical regression and moderated mediation analyses on a dataset consisting of 373 responses. The results reveal that GEO significantly influences GCA, with both radical and incremental GI (IGI) partially mediating this relationship. Moreover, the relationship between GEO, radical GI (RGI), and GCA is strengthened when GAC is high. The moderated mediating effects reveal that the mediating role of RGI is more pronounced when GAC is high. These findings provide valuable insights into enhancing green competitiveness by promoting eco‐innovation in manufacturing companies and advancing green entrepreneurship research.
Catalytic and Selective Red Light‐Triggered Photodegradation of a G‐Quadruplex DNA by a Zinc (II) Phthalocyanine
Authors: Odahara Yusuke , Momotake Atsuya , Syokaku Yuri , Yamamoto Yasuhiko 
Published: June 2024

AbstractWater‐soluble phthalocyanine (Pc) derivatives have been regarded as potential G‐quadruplex (G4) nucleic acid‐targeting ligands for anticancer therapy and have been extensively studied as effective photosensitizers for photodynamic therapy (PDT). Understanding how photosensitizers interact with nucleic acids and the subsequent photolytic reactions is essential for deciphering the initial steps of PDT, thereby aiding in the development of new photosensitizing agents. In this study, we found that red‐light irradiation of a mixture of a Zn(II) Pc derivative and an all‐parallel G4 DNA leads to catalytic and selective photodegradation of the DNA by reactive oxygen species (ROS) generated from the Zn(II) Pc derivative bound to DNA through a reaction mechanism similar to that of an enzyme reaction. This finding provides a novel insight into the molecular design of a photosensitizer to enhance its PDT efficacy.
Tumor Acidity‐Triggered Bioorthogonal Reactions for Biomedical Applications
Authors: Liu Xiajian , Ullah Ihsan , Yuan Youyong 
Published: June 2024

AbstractCancer is one of the most serious threats to human health. Over the past few years, researchers have incrementally uncovered the pivotal role of tumor acidity in tumor formation, development, and treatment. In addition, bioorthogonal reactions have been widely used in tumor diagnosis and therapy, owing to their advantageous characteristics, including small ligand size, biocompatibility, fast reaction kinetics, and high chemospecificity. Consequently, bioorthogonal reactions triggered by tumor acidity have become an emerging strategy in biomedical applications. On this basis, we first elucidate the concept and major strategies of tumor acidity‐triggered bioorthogonal reactions. Additionally, we review the progress in biomedical applications, with a particular focus on their importance in disease diagnosis and treatment. Finally, clinical challenges and future trends are also outlooked.