bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric and textural analysis of PET/CT in patients with diffuse large B-cell lymphoma highlights the importance of novel MTVrate feature
Authors: Czibor Sándor , Csatlós Zselyke , Fábián Krisztián , Piroska Márton , Györke Tamás 
Published: August 2024

Objectives
To investigate the prognostic value of clinical, volumetric, and radiomics-based textural parameters in baseline [18F]FDG-PET/CT scans of diffuse large B-cell lymphoma (DLBCL) patients.

Methods
We retrospectively investigated baseline PET/CT scans and collected clinical data of fifty DLBCL patients. PET images were segmented semiautomatically to determine metabolic tumor volume (MTV), then the largest segmented lymphoma volume of interest (VOI) was used to extract first-, second-, and high-order textural features. A novel value, MTVrate was introduced as the quotient of the largest lesion’s volume and total body MTV. Receiver operating characteristics (ROC) analyses were performed and 24-months progression-free survival (PFS) of low- and high-risk cohorts were compared by log-rank analyses. A machine learning algorithm was used to build a prognostic model from the available clinical, volumetric, and textural data based on logistic regression.

Results
The area-under-the-curve (AUC) on ROC analysis was the highest of MTVrate at 0.74, followed by lactate-dehydrogenase, MTV, and skewness, with AUCs of 0.68, 0.63, and 0.55, respectively which parameters were also able to differentiate the PFS. A combined survival analysis including MTV and MTVrate identified a subgroup with particularly low PFS at 38%. In the machine learning-based model had an AUC of 0.83 and the highest relative importance was attributed to three textural features and both MTV and MTVrate as important predictors of PFS.

Conclusion
Individual evaluation of different biomarkers yielded only limited prognostic data, whereas a machine learning-based combined analysis had higher effectivity. MTVrate had the highest prognostic ability on individual analysis and, combined with MTV, it identified a patient group with particularly poor prognosis.
Extent of Myometrial Resection With Various Surgical Methods for Endometrial Polypectomy Procedures
Authors: Evans-Hoeker Emily , Millner Adrienne , Lee Grace , Perry Ryan , Kar Ayesha , Swaroop Meyha , Locklear Tonja , Newman Brian , Casey James 
Published: August 2024

OBJECTIVE:
To assess whether the frequency and extent of myometrial resection differs among surgical methods commonly used for endometrial polypectomy.

METHODS:
We conducted a retrospective cohort study of pathology samples from polypectomy procedures performed on patients 18–50 years of age. Samples were reevaluated by a blinded pathologist to assess the following primary outcome measures: presence and percentage of myometrium on the pathology sample, prevalence of isolated myometrium, and depth of myometrial resection. Data were evaluated using Fisher exact test and Kruskal-Wallis test, followed by multiple comparisons analysis. To maintain a familywise error rate of 5% across all four primary analyses, the Bonferroni correction method was applied.

RESULTS:
Of 458 pathology samples, 21.8% were obtained using hysteroscopic morcellators, 11.1% were obtained with hysteroscopic scissors, and 67.0% were obtained with hysteroscopy with dilation and curettage (D&C). Hysteroscopic morcellation demonstrated a higher prevalence of myometrium (58.0% vs 9.8% and 15.3%, for hysteroscopic scissors and hysteroscopy with D&C, respectively; P<.001), a larger percentage of pathology samples with more than 25% myometrium (26.0% vs 4.0% and 0.6%, respectively; P<.001), and a higher prevalence of isolated myometrium compared with hysteroscopy with D&C (11.0% vs 0.7%; P<.001).

CONCLUSION:
The presence and proportion of myometrium in polypectomy samples obtained using hysteroscopic morcellators was significantly higher compared with hysteroscopic scissors and hysteroscopy with D&C.
Timing of Antidepressant Use in Pregnancy and Preterm Birth
Authors: Wang Jenny , Roy Debosree , Wang Mary Ying-Fang , Dinh Diana , Lao Ailina , Mendoza Valeria , Xu Gillian , Chatterton Carolyn G. , Ahmadieh Nazanin 
Published: August 2024

OBJECTIVE:
To evaluate the implication of timing of antidepressant exposure on preterm birth to better guide clinical counseling.

DATA SOURCES:
A systematic review and meta-analysis was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, using PubMed, MEDLINE Complete, EBSCO, CINAHL Plus, and ClinicalTrials.gov along with a manual search of references in relevant publications. The databases were searched between January 2000 and December 2022 with the following keywords: antidepressants, antidepressant medication, SSRI, selective serotonin reuptake inhibitors, TCA, or SNRI AND pregnancy, pregnant, prenatal, antenatal, perinatal, maternal AND trimester or timing AND preterm or premature.

METHODS OF STUDY SELECTION:
The database search resulted in 162 studies. The 13 studies that met inclusion criteria compared preterm birth rates in pregnant patients exposed to antidepressants at a specified time in pregnancy (early, late, or throughout pregnancy) and a control group. Covidence was used for screening and data extraction. Excel and R were used for tabulation and statistical analysis, respectively.

TABULATION, INTEGRATION, AND RESULTS:
Of the 13 studies, nine measured preterm birth rates with antidepressant use in early pregnancy, 10 in late pregnancy, and four throughout pregnancy. Separate random effects models were used to synthesize the effect sizes from studies that did not adjust for presence of maternal depression in the study sample and those that did. In each model, subgroup analysis was conducted to assess the effect of timing of antidepressant exposure on the odds of preterm birth. In the model unadjusted for depression, pooled odds ratios (ORs) for the association between use of antidepressants and preterm birth were 1.41 (95% CI, 1.10–1.81) in early pregnancy, 1.51 (95% CI, 1.26–1.82) in late pregnancy, and 2.79 (95% CI, 1.27–6.12) throughout pregnancy. After adjusting for depression, the pooled ORs were 1.04 (95% CI, 0.83–1.31) in early pregnancy, 1.26 (95% CI, 0.95–1.66) in late pregnancy, and 1.79 (95% CI, 0.54–5.91) throughout pregnancy. No significant effect of timing was found in either model.

CONCLUSION:
Antidepressant use in pregnancy was not associated with preterm birth, regardless of timing of use. Pregnant patients with an established diagnosis of depression should receive individualized counseling regarding antidepressant use while taking into consideration their risk factors for preterm birth and the implications of untreated depression.

SYSTEMATIC REVIEW REGISTRATION:
PROSPERO, CRD42023390136.
Rehabilitation after musculoskeletal injury: an overview of systems in the United States and Canada
Authors: Miclau Theodore A. , Pascual Lisa , Ndoja Silvio , Frazer Abigail , Beaupre Lauren , Schemitsch Emil H. 
Published: August 2024

Abstract
As North America is largely industrialized with a variety of available private transportation options, trauma is a common occurrence, resulting in significant burdens of disability and costs to the health care system. To meet increasing trauma care needs, there is a robust organization of trauma and rehabilitation systems, particularly within the United States and Canada. The American and Canadian health care systems share multiple similarities, including well-equipped Level I trauma centers, specialized inpatient rehabilitation units for polytrauma patients, and thorough evaluations for recovery and post-discharge placement. However, they also have several key differences. In Canada, the criteria for admission to inpatient rehabilitation vary by location, and inpatient rehabilitation is universally accessible, whereas outpatient rehabilitation services are generally not covered by insurance. In the United States, these admission criteria for post-acute inpatient rehabilitation are standardized, and both inpatient and outpatient services are covered by private and government-funded insurance with varying durations. Overall, both health care systems face challenges in post-acute rehabilitation, including benefit limitations and limited provider access in rural areas, and must continue to evolve to meet the rehabilitation needs of injured patients as they reintegrate into their communities.
Rehabilitation after musculoskeletal injury: European perspective
Authors: Kelly Michael , Donovan Richard L. , Dailiana Zoe H. , Pape Hans-Christophe , Chana-Rodríguez Francisco , Pari Carlotta , Ponsen Kornelis Jan , Cattaneo Stefano , Belluati Alberto , Contini Achille , Gómez-Vallejo Jesús , Casallo-Cerezo Marta , Willinge Gijs J.A. , van Veen Ruben N. , Goslings J. Carel , Papadakis Stamatios A.N. , Iliopoulos Efthymios 
Published: August 2024

Abstract
Trauma is one of the main causes of death in younger people and ongoing disability worldwide. In Europe, while there is generally good organization of trauma reception and acute treatment, rehabilitation from major musculoskeletal injuries is less well defined and provided. This article documents the diverse approaches to rehabilitation after major injury in 6 European nations. The recognition of need is universal, but achieving a robust rehabilitation strategy is more elusive across the varying health care systems. Switzerland has the most robust service in the insured population. In the other countries, particularly where there is a reliance on public institutes, this provision is at best patchy. In the Netherlands, innovative patient-empowering strategies have gained traction with notable success, and in the United Kingdom, a recent randomized trial also showed this approach to be reproducible and robust. Overall, there is a clear need for learning across the national systems and implementation of a minimum set of standards.
Comparison between cycloplegic and noncycloplegic refraction in young adult myopes
Authors: Khan Hashim Ali , Tran Huy , Naduvilath Thomas John , Tahhan Nina , Ha Thao , Sankaridurg Padmaja 
Published: August 2024

SIGNIFICANCE
This study explores the difference between cycloplegic and noncycloplegic refraction in young adult myopes.

PURPOSE
From the available literature, it is unclear whether cycloplegia is necessary when refracting young adults. This study investigates the agreement between noncycloplegic autorefraction and cycloplegic autorefraction and investigates factors affecting the agreement between the two methods.

METHODS
In total, 125 myopes with ages ranging between 18 and 26 years were included from Australia and Vietnam. Each participant underwent noncycloplegic autorefraction and cycloplegic autorefraction. Cycloplegia was induced with 1% ophthalmic tropicamide.

RESULTS
The mean spherical equivalent difference (95% confidence interval) between noncycloplegic autorefraction and cycloplegic autorefraction was −0.20 D (−0.25 to −0.14 D; t
124 = −7.18, p<0.0001). A mean difference of >0.25 D was seen in 46.8% of eyes. The lower and upper limits of agreement were −0.80 and 0.41 D, respectively. With univariate analysis, factors including age, degree of refractive error, accommodation amplitude, and distance phorias showed no impact on the average difference between cycloplegic autorefraction and noncycloplegic autorefraction. Yet, eyes with near exophoria (F
2,120 = 6.63, p=0.0019) and Caucasian eyes (F
3,121 = 2.85, p=0.040) exhibited the smallest paired differences. However, in the multivariate analysis, only near exophoria was associated with a lower mean difference. A significantly smaller proportion (34.9%) of eyes with near exophoria had a paired difference of −0.25 D or more compared with esophoria (50%) and orthophoria (65%; χ
2 = 6.6, p=0.038).

CONCLUSIONS
Noncycloplegic autorefraction results in more myopic refractive error than cycloplegic autorefraction in young adults.
Current challenges in neurocysticercosis: recent data and where we are heading
Authors: Coyle Christina M. , Bustos Javier A. , Garcia Hector H. 
Published: August 2024

Purpose of review
Neurocysticercosis (NCC) is still a significant contributor to neurological disease in vast regions of the world, and increasingly diagnosed in nonendemic countries because of travel and immigration from endemic settings. There is a need for clinicians in endemic and nonendemic regions to understand the complexities of its diagnosis and management.

Recent findings
Recent information on the performance and use of available imaging and immunodiagnostic tools as well as antiparasitic and anti-inflammatory therapeutic regimes were assessed.

Summary
Imaging and serology data should be assessed in the context of the specific type of NCC to improve diagnostic precision. In terms of therapeutic approaches, more controlled data is required on the efficacy and safety of combined antiparasitic therapy, and antiseizure and anti-inflammatory regimes should be optimized to minimize perilesional damage and reduce the risk of epilepsy.
Preliminary attempt to inhibit proliferation of NUT carcinoma cell lines using antisense oligonucleotides targeting NUTM1
Authors: Alley Jessica , Vincent Benjamin G. , Rubinsteyn Alexander 
Published: August 2024

AbstractNUT carcinoma is an aggressive cancer driven by NUTM1 fusion proteins. This study evaluated antisense oligonucleotides (ASOs) targeting NUTM1 as a potential therapeutic approach. Three ASOs targeting NUTM1 and scrambled controls were tested at 10-50 nM doses in three NUT carcinoma cell lines (TC-797, 10-15, 14169) and one control line (293T). ASOs were delivered both gymnotically and using a transfection reagent. Cell viability was assessed at 48 and 72 hours using a luminescence-based assay. No ASOs showed selective inhibition of NUT carcinoma cell viability compared to controls across all conditions tested. Thus, this pilot study did not identify ASOs with activity against NUT carcinoma cells. However, it did establish preliminary protocols and generated data to inform future ASO optimization efforts targeting NUTM1 in NUT carcinoma. Further refinement of ASO design and delivery methods is needed to identify therapeutic candidates.Graphical AbstractHypothesisThis experiment was performed as a pilot experiment to generate data to inform future work, which should include formal hypothesis testing with a reduced number of conditions. The hypothesis of this pilot experiment was that one or more of the non-scrambled antisense oligonucleotides (ASOs) targeting NUTM1 will selectively decrease proliferation and/or viability of NUT carcinoma cells, indicated by a reduction in luminescence (as compared to treated non-NUT carcinoma and untreated NUT carcinoma control cells) using the CellTiter-Glo Luminescent Cell Viability Assay.
Genetic risk score-informed re-evaluation of spirometry quality control to maximise power in epidemiological studies of lung function
Authors: Chen Jing , Shrine Nick , Izquierdo Abril G , Guyatt Anna , Völzke Henry , London Stephanie , Hall Ian P , Dudbridge Frank ,   SpiroMeta Consortium,   CHARGE Consortium, Wain Louise V , Tobin Martin D , John Catherine 
Published: August 2024

AbstractBackground and aimEpidemiological studies of lung function may discard one-third to one-half of participants due to spirometry measures deemed “low quality” using criteria adapted from clinical practice. We aimed to define new spirometry quality control (QC) criteria that optimise the signal-to-noise ratio in epidemiological studies of lung function.Material and methodsWe proposed a genetic risk score (GRS) informed strategy to categorize spirometer blows according to quality criteria. We constructed three GRSs comprised of SNPs associated with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and the ratio of FEV1to FVC (FEV1/FVC) in individuals from non-UK Biobank cohorts included in prior genome-wide association studies (GWAS). In the UK Biobank, we applied a step-wise testing of the GRS association across groups of spirometry blows stratified by acceptability flags to rank the blow quality. To reassess the QC criteria, we compared the genetic association results between analyses including different acceptability flags and applying different repeatability thresholds for spirometry measurements to determine the trade-off between sample size and measurement error.ResultsWe found that including blows previously excluded for cough, hesitation, excessive time to peak flow, or inadequate terminal plateau, and applying a repeatability threshold of 250ml, would maximise the statistical power for GWAS and retain acceptable precision in the UK Biobank. This approach allowed the inclusion of 29% more participants compared to the strictest ATS/ERS guidelines.ConclusionOur findings demonstrate the utility of GRS-informed QC to maximise the power of epidemiological studies for lung function traits.
Health Utility Value of Overactive Bladder in Japanese Older Adults
Authors: Yoshioka Takashi , Omae Kenji , Funada Satoshi , Minami Tetsuji , Goto Rei 
Published: August 2024

AbstractObjectivesTo determine the health utility values (HUVs) of overactive bladder (OAB) among adults aged ≥65 years and to assess the HUV decrements (disutilities) of OAB according to its severity.MethodsThis cross-sectional Internet-based study was conducted between 2 and 9 November 2023, with quota sampling with equal probability for each gender and age group (age 65–74 years and ≥75 years). OAB was defined as an urgency score of ≥2 points and a total score of ≥3 points based on the Overactive Bladder Symptom Score. OAB severity was categorized as mild (total score, ≤5 points) or moderate-to-severe (total score, 6–15 points). HUVs were measured using the EuroQol 5-Dimension 5-Level value set for the Japanese population. Multivariable linear regression models were fitted to estimate the covariate-adjusted disutilities of OAB, with eight covariates selected based on previous studies.ResultsAmong the 998 participants (51.9% male; mean age, 73.2 years), 158 (15.9%) had OAB, of whom 87 (8.8%) had moderate-to-severe OAB. The mean HUVs for participants with mild and moderate-to-severe OAB were 0.874 and 0.840, respectively, which were lower compared with the HUV for those without OAB (0.913). After adjusting for relevant covariates, disutilities (95% confidence intervals [CIs]) for mild and moderate-to-severe OAB were –0.0334 (–0.0602 to –0.0066) and –0.0591 (–0.0844 to –0.0339), respectively.ConclusionsThis study examined HUVs in older Japanese adults with and without OAB. The results demonstrate that increased OAB severity is associated with greater disutility.
Neutralizing antibodies elicited in sequentially immunized macaques recognize V3 residues on altered conformations of HIV-1 Env trimer
Authors: DeLaitsch Andrew T. , Keeffe Jennifer R. , Gristick Harry B. , Lee Juliet A. , Ding Wenge , Liu Weimin , Skelly Ashwin N. , Shaw George M. , Hahn Beatrice H. , Björkman Pamela J. 
Published: August 2024

SummaryEliciting broadly neutralizing antibodies that protect against diverse HIV-1 strains is a primary goal of AIDS vaccine research. We characterized Ab1456 and Ab1271, two heterologously-neutralizing antibodies elicited in non-human primates by priming with an engineered V3-targeting SOSIP Env immunogen and boosting with increasingly native-like SOSIP Envs derived from different strain backgrounds. Structures of Env trimers in complex with these antibodies revealed V3 targeting, but on conformational states of Env distinct from the typical closed, prefusion trimeric SOSIP structure. Env trimers bound by Ab1456 adopted conformations resembling CD4-bound open Env states in the absence of soluble CD4, whereas trimers bound by Ab1271 exhibited a trimer apex-altered conformation to accommodate antibody binding. The finding that elicited antibodies cross-neutralized by targeting altered, non-closed, prefusion Env trimer conformations provides important information about Env dynamics that is relevant for HIV-1 vaccine design aimed at raising antibodies to desired epitopes on closed pre-fusion Env trimers.Highlights-Sequential immunization regimen elicits V3 antibodies targeting non-closed Envs-Cryo-EM structures reveal recognition of multiple Env conformational states-Neutralization by elicited antibody does not require antibody-virus preincubationGraphical Abstract
Salidroside Mitigates Malignant Arrhythmias by Restoring Sodium Channel Function During Ultra-Acute Myocardial Infarction
Authors: Wang Gongxin , Zhao Yilin , Zhang Chenchen , Dong Xiuming , Sun Siyu , Wang Xiulong , Li Dongxu , Li Xuefang , Li Huan , Lu Chieh-Ju , Du Yimei , Chen Zhigang , Lin Fei , Hao Guoliang 
Published: August 2024

AbstractBackgroundThe ultra-acute phase (Phase 1a) of acute myocardial infarction (AMI) is marked by a high incidence of malignant arrhythmias, often occurring during the prehospital period. Currently, there are no effective treatment options available for managing these arrhythmias at this early stage.Methods and ResultsUsing dual-channel optical mapping, we simultaneously recorded membrane potentials and calcium transients during acute myocardial infarction. Calcium transient duration maps accurately localized the infarcted region, and action potential activation time maps revealed conduction heterogeneity in the infarcted zone. Patch-clamp recordings showed that Salidroside (Sal) (1 µg/mL) significantly increased sodium current density from -59.27 ± 2.15 pA/pF to -83.46 ± 3.19 pA/pF (P<0.01) and shifted the Nav1.5 activation curve leftward (V1/2 from -37.27 ± 0.5 mV to -44.55 ± 0.7 mV, P<0.01). In rat and rabbit AMI models, Sal pre-treatment reduced conduction heterogeneity and arrhythmia incidence compared to controls. Optical mapping showed improved conduction velocity and uniformity in the Sal group.ConclusionsSal restores electrophysiological function in damaged myocardium by modulating sodium currents, reducing conduction heterogeneity, and decreasing malignant arrhythmia incidence during the ultra-acute phase of AMI. These findings suggest a novel therapeutic strategy for AMI, addressing a critical unmet need in antiarrhythmic therapy.What is New?This study identifies Salidroside (Sal) as a novel agent that enhances sodium channel currents (Nav1.5), distinguishing it from traditional antiarrhythmic drugs which primarily target potassium channels or β-adrenergic receptors. Sal improves conduction uniformity in the infarcted myocardium by restoring the electrophysiological function of damaged cardiac cells, eliminating slow conduction pathways, and reducing conduction heterogeneity.This research introduces Sal as a promising candidate for preventing and treating arrhythmias during the critical early stages of MI, potentially improving patient outcomes. Sal administration during the ultra-acute phase (phase 1a) of myocardial infarction (MI) significantly reduces the incidence of malignant arrhythmias, a critical period characterized by high extracellular potassium and increased arrhythmia risk.Utilizing calcium transient imaging and optical mapping, this study provides precise localization of ischemic regions and detailed electrophysiological characterization, offering a robust methodology for assessing therapeutic efficacy.