bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-Faktor yang Mempengaruhi Keberlanjutan Usaha Keluarga (Studi pada Usaha Kain Tenun Ikat di Kecamatan Pahunga Lodu)
Authors: Ahing Marlon Kateka , Situmorang Tumpal Pangihutan 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui keberlanjutan usaha keluarga kain tenun ikat di kecaatan Pahunga Lodu. Kesuksesan sebuah usaha keluarga berkaitan dengan fenomena keberlanjutan pada usaha keluarga. Untuk ekonomi dan kepentingan keberlanjutan usaha keluarga, penting untuk menentikan faktor-faktor yang dapat mempengaruhi keberlanjutan usaha keluarga. Sehingga penelitian ini akan menentukan faktor-faktor yang berpengaruh pada keberlanjutan usaha keluarga kain tenun ikat di kecamatan Pahunga Lodu. Jumlah sampel dalam penelitian ini adalah 70 responden yang berdomisili di kecamatan Pahunga Lodu dan memiliki usaha yang telah berjalan selama dua generasi. Untuk menganalisis data penelitian ini menggunakan aplikasi SPSS versi 25. Analisis yang digunakan adalah analisis regresi linier berganda. Hasil dari penelitian ini menunjukan bahwa Pemikiran Kewirausahaan (X1) dan Penyelesaian Konflik (X4) tidak berpengaruh terhadap Keberlanjutan Usaha Keluarga (Y). Berbagi Pengetahuan (X2) dan Pengalaman (X3) berpengaruh terhadap Keberlanjutan Usaha Keluarga (Y).
Reputasi Toko, Kepercayaan Konsumen dan Harga terhadap Keputusan Pembelian (Studi pada Online Shop Bls Shop2 di Kota Waingapu)
Authors: Mburu Ida Kalita , Situmorang Tumpal Pangihutan 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh reputasi toko, kepercayaan konsumen, dan harga terhadap keputusan pembelian. Variabel independen pada penelitian ini adalah reputasi toko, kepercayaan konsumen dan harga, sedangkan variable dependen pada penelitian ini adalah keputusan pembelian. Populasi data yang diteliti adalah konsumen di Bls Shop2 Waingapu. Teknik analisis data yang di gunakan adalah Patrial Least Square (PLS). hasil analisis menunjukkan bahwa reputasi toko berpengaruh signifikan terhadap keputusan pembelian, kepercayaan konsumen berpengaruh signifikan terhadap keputusan pembelian dan harga berpengaruh signifikan terhadap keputusan pembelian.
Análise quantitativa e temporal das características epidemiológicas da espinha bífida no período de janeiro de 2013 a dezembro de 2023
Authors: Anjos Rainara Pereira dos , Leite Rodrigo Pessoa , Paradis Rafael Joseph Macedo , Oliveira Francisco José de Andrade , Silveira Flávio Damuêdo , Santos Arthur Vinícius Feitosa , Lacerda Gabrielle Maia de , Bispo Mayara Oliveira , Silva Levy Figueiredo da , Azevedo Luiz Phillipe Silva 
Published: July 2024

Objetivo: Analisar quantitativa e espacialmente as características epidemiológicas da espinha bífida no período de Janeiro de 2013 a Dezembro de 2023. Metodologia: Trata-se de um estudo epidemiológico, com caráter descritivo e quantitativo sobre as características epidemiológicas da espinha bífida no Brasil, realizado tendo como embasamento os dados do departamento de informação de saúde do SUS (Sistema Único de Saúde). As variáveis utilizadas foram: internações hospitalares, taxa de mortalidade, óbitos, faixa-etária, cor/raça, sexo, caráter de atendimento e macrorregião de saúde. A demais, tais dados do Sistema de informação da saúde do SUS foram cruzados com informações de pesquisa levantadas a partir da leitura de artigos vinculados à Scielo e Pubmed. Resultados: Nos estudos observou-se 11.530 casos de espinha bífida no Brasil entre 2013 a 2023. A região Nordeste foi responsável por 4.804 casos, seguida da região Sudeste com 3.694 casos. Quanto ao número de internações por ano, conclui-se que o ano de 2015 apresentou 1.205 internações, seguido de 2016 com 1.175. De acordo com a faixa etária, o número de internações em menores de 1 ano foi de 7.880. Indivíduos da cor branca e do sexo feminino foram os mais acometidos. Conclusão: O Nordeste foi o estado com o maior número de internações, bem como o ano de 2015, sendo o ano com menor número de hospitalizações o de 2013. A faixa etária mais acometida foram os menores 1 ano. Nesta perspectiva, encara-se a espinha bífida como um grave problema de saúde pública.
Effectiveness of customized ortho-k lenses in controlling myopia in children
Authors: Kalinina L. P. , Makarovskaya O. V. , Kalinin R. G. , Popov V. V. 
Published: July 2024

Background. The increasing prevalence of myopia in children highlights the need for effective treatments. Orthokeratology is a key approach to slow myopia progression, yet standard ortho-k lenses often fall short due to diverse corneal structures. Personalized ortho-lens designs are crucial for optimizing myopia control and maximizing the benefits of corneal refractive therapy.Aim: to evaluate the impact of custom ortho-k lens use on myopia control in children, specifically assessing changes in refraction and axial length during orthokeratology treatment.Materials and methods. In our study, 41 school-aged children underwent custom orthokeratology treatment with 81 ortho-k lenses. Utilizing a Medmont E300 for corneal topography and the OrthoTool for lens calculations, alongside Lenstar LS 900 for optical biometry, we assessed myopia progression and axial elongation. The subjects’ average age was 12.6 ± 2.4 years, with an average lens wear duration of 17.0 months (range 10.0 to 23.5 months). Initial mean myopia was –5.5 ± 2.0 D in both eyes.Results. During the study period, 87.8% of the participants (36 children) showed stabilization in refraction and axial length, indicating effective myopia control. However, 12.2% (5 children) experienced myopia progression at a rate of –0.5 diopters per year. Notably, all children undergoing orthokeratology treatment achieved high visual acuity (0.9–1.0). Complications were limited to 12.2% of the participants, who developed mild epitheliopathy (2 degrees) and/or Fleischner rings; no inflammatory complications were observed.Conclusions. Customized orthokeratology offers significant advantages over standard ortho-k lenses, tailoring treatment to individual corneal structures for more effective myopia control. The results advocate for further, long-term studies into customized orthokeratology and its role in managing myopia.
Chest CT Findings at Six Months Following COVID-19 ARDS – Correlation With the mMRC Dyspnea Scale and Pulmonary Function Tests
Authors: Garg Mandeep , Prabhakar Nidhi , Devkota Shritik , Dhooria Sahajal , Debi Uma , Dua Ashish , Singh Tarvinder , Malarakunte Muniraju , Bhatia Harsimran , Sandhu Manavjit Singh 
Published: July 2024

Background: Many survivors of severe COVID-19 pneumonia experience lingering respiratory issues. There is limited research on follow-up chest imaging findings in patients with COVID-19 ARDS, particularly in relation to their mMRC dyspnea scores and pulmonary function tests (PFTs). This study addresses this gap by investigating the clinical characteristics, mMRC dyspnea scores, PFTs, and chest CT findings of COVID-19 ARDS patients at the 6 months post-recovery. By analyzing these variables together, we aim to gain a better understanding of the long-term health consequences of COVID-19 ARDS.Methods: This prospective observational study included 56 subjects with COVID-19 ARDS with dyspnea at the six-month follow-up visits. These patients were evaluated by chest CT, mMRC dyspnea scale, and PFT. The CT severity score was calculated individually for each of the four major imaging findings - ground glass opacities (GGOs), parenchymal/atelectatic bands, reticulations/septal thickening, and consolidation - using a modified CT severity scoring system. Statistics were carried out to find any association between individual CT chest findings and the mMRC dyspnea scale and forced vital capacity (FVC). p values &lt; 0.05 were considered statistically significant.Results: Our study population had a mean age of 55.86 ± 9.60 years, with 44 (78.6%) being men. Grades 1, 2, 3, and 4 on the mMRC dyspnea scale were seen in 57.1%, 30.4%, 10.7%, and 1.8% of patients respectively. Common CT findings observed were GGOs (94.6%), reticulations/septal thickening (96.4%), parenchymal/atelectatic bands (92.8%), and consolidation (14.3%). The mean modified CT severity scores for GGOs, reticulations/septal thickening, parenchymal/atelectatic bands, and consolidation were 10.32 ± 5.51 (range: 0–21), 7.66 ± 4.33 (range: 0–19), 4.77 ± 3.03 (range: 0–14) and 0.29 ± 0.91 (range 0–5) respectively. Reticulations/septal thickening (p = 0.0129) and parenchymal/atelectatic bands (p = 0.0453) were associated with an increased mMRC dyspnea scale. Parenchymal/atelectatic bands were also associated with abnormal FVC (&lt;80%) (p = 0.0233).Conclusion: Six-month follow-up chest CTs of COVID-19 ARDS survivors with persistent respiratory problems showed a statistically significant relationship between increased mMRC dyspnea score and imaging patterns of reticulations/septal thickening and parenchymal/atelectatic bands; while parenchymal/atelectatic bands also showed a statistically significant correlation with reduced FVC.
Prediction of visceral adipose tissue magnitude using a new model based on simple clinical measurements
Authors: Torun Cundullah , Ankaralı Handan , Caştur Lütfullah , Uzunlulu Mehmet , Erbakan Ayşe Naciye , Akbaş Muhammet Mikdat , Gündüz Nesrin , Doğan Mahmut Bilal , Bahadır Müzeyyen Arslan , Oğuz Aytekin 
Published: July 2024

AimsWaist circumference (WC) is a reliable obesity surrogate but may not distinguish between visceral and subcutaneous adipose tissue. Our aim was to develop a novel sex-specific model to estimate the magnitude of visceral adipose tissue measured by computed tomography (CT-VAT).MethodsThe model was initially formulated through the integration of anthropometric measurements, laboratory data, and CT-VAT within a study group (n=185), utilizing the Multivariate Adaptive Regression Splines (MARS) methodology. Subsequently, its correlation with CT-VAT was examined in an external validation group (n=50). The accuracy of the new model in estimating increased CT-VAT (&gt;130 cm2) was compared with WC, body mass index (BMI), waist-hip ratio (WHR), visceral adiposity index (VAI), a body shape index (ABSI), lipid accumulation product (LAP), body roundness index (BRI), and metabolic score for visceral fat (METS-VF) in the study group. Additionally, the new model’s accuracy in identifying metabolic syndrome was evaluated in our Metabolic Healthiness Discovery Cohort (n=430).ResultsThe new model comprised WC, gender, BMI, and hip circumference, providing the highest predictive accuracy in estimating increased CT-VAT in men (AUC of 0.96 ± 0.02), outperforming other indices. In women, the AUC was 0.94 ± 0.03, which was significantly higher than that of VAI, WHR, and ABSI but similar to WC, BMI, LAP, BRI, and METS-VF. It’s demonstrated high ability for identifying metabolic syndrome with an AUC of 0.76 ± 0.03 (p&lt;0.001).ConclusionThe new model is a valuable indicator of CT-VAT, especially in men, and it exhibits a strong predictive capability for identifying metabolic syndrome.
Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity
Authors: Radushev Veselina , Karkossa Isabel , Berg Janina , von Bergen Martin , Engelmann Beatrice , Rolle-Kampczyk Ulrike , Blüher Matthias , Wagner Ulf , Schubert Kristin , Rossol Manuela 
Published: July 2024

IntroductionObesity is associated with a plethora of health complications, including increased susceptibility to infections or decreased vaccine efficacy, partly due to dysregulated immune responses. Monocytes play a crucial role in innate immunity, yet their functional alterations in obesity remain poorly understood.MethodsHere, we employed proteomic and metabolomic analyses to investigate monocyte characteristics in individuals with overweight, obesity, impaired glucose tolerance (IGT), and type 2 diabetes (T2D), compared to lean donors.Results and discussionOur results revealed distinct molecular signatures in monocytes from individuals with obesity, with significant alterations in pathways related to metabolism, cellular migration, and phagocytosis. Moreover, LPS-induced activation of monocytes unveiled heightened metabolic reprogramming towards glycolysis in subjects with obesity accompanied by dysregulated cytokine responses and elevated oxidative stress. Additionally, monocytes from donors with obesity exhibited increased lipid droplet accumulation. These findings shed light on the immunometabolic dysregulation underlying obesity-associated immune dysfunction, highlighting potential targets for therapeutic intervention.
Establishment and characterization of an hACE2/hTMPRSS2 knock-in mouse model to study SARS-CoV-2
Authors: Liu Hongwei , Brostoff Terza , Ramirez Ana , Wong Talia , Rowland Douglas J. , Heffner Mollie , Flores Arturo , Willis Brandon , Evans Jeffrey J. , Lanoue Louise , Lloyd K. C. Kent , Coffey Lark L. 
Published: July 2024

Despite a substantial body of research, we lack fundamental understanding of the pathophysiology of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including pulmonary and cardiovascular outcomes, in part due to limitations of murine models. Most models use transgenic mice (K18) that express the human (h) angiotensin converting enzyme 2 (ACE2), ACE2 knock-in (KI) mice, or mouse-adapted strains of SARS-CoV-2. Further, many SARS-CoV-2 variants produce fatal neurologic disease in K18 mice and most murine studies focus only on acute disease in the first 14 days post inoculation (dpi). To better enable understanding of both acute (&lt;14 dpi) and post-acute (&gt;14 dpi) infection phases, we describe the development and characterization of a novel non-lethal KI mouse that expresses both the ACE2 and transmembrane serine protease 2 (TMPRSS2) genes (hACE2/hTMPRSS2). The human genes were engineered to replace the orthologous mouse gene loci but remain under control of their respective murine promoters, resulting in expression of ACE2 and TMPRSS2 instead of their murine counterparts. After intranasal inoculation with an omicron strain of SARS-CoV-2, hACE2/hTMPRSS2 KI mice transiently lost weight but recovered by 7 dpi. Infectious SARS-CoV-2 was detected in nasopharyngeal swabs 1-2 dpi and in lung tissues 2-6 dpi, peaking 4 dpi. These outcomes were similar to those in K18 mice that were inoculated in parallel. To determine the extent to which hACE2/hTMPRSS2 KI mice are suitable to model pulmonary and cardiovascular outcomes, physiological assessments measuring locomotion, behavior and reflexes, biomonitoring to measure cardiac activity and respiration, and micro computed tomography to assess lung function were conducted frequently to 6 months post inoculation. Male but not female SARS-CoV-2 inoculated hACE2/hTMPRSS2 KI mice showed a transient reduction in locomotion compared to control saline treated mice. No significant changes in respiration, oxygen saturation, heart rate variability, or conductivity were detected in SARS-CoV-2 inoculated mice of either sex. When re-inoculated 6 months after the first inoculation, hACE2/hTMPRSS2 KI became re-infected with disease signs similar to after the first inoculation. Together these data show that a newly generated hACE2/hTMPRSS2 KI mouse can be used to study mild COVID-19.
Exploring the causal relationship between body mass index and keratoconus: a Mendelian randomization study
Authors: Wang Jiaoman , Liu Fangyuan , Mo Jianhao , Gong Di , Zheng Fang , Su Jingjing , Ding Sicheng , Yang Weihua , Guo Ping 
Published: July 2024

BackgroundDespite reports suggesting a link between obesity and keratoconus, the causal relationship is not fully understood.MethodsWe used genome-wide association study (GWAS) data from public databases for a two-sample Mendelian randomization analysis to investigate the causal link between body mass index (BMI) and keratoconus. The primary method was inverse variance weighted (IVW), complemented by different analytical techniques and sensitivity analyses to ensure result robustness. A meta-analysis was also performed to bolster the findings’ reliability.ResultsOur study identified a significant causal relationship between BMI and keratoconus. Out of 20 Mendelian randomization (MR) analyses conducted, 9 showed heterogeneity or pleiotropy. Among the 11 analyses that met all three MR assumptions, 4 demonstrated a significant causal difference between BMI and keratoconus, while the remaining 7 showed a positive trend but were not statistically significant. Meta-analysis confirmed a significant causal relationship between BMI and keratoconus.ConclusionThere is a significant causal relationship between BMI and keratoconus, suggesting that obesity may be a risk factor for keratoconus.
High-frequency ultrasound with superb microvascular imaging: a potential tool for ultrasound assessment in patients with giant cell arteritis
Authors: Skoog Johan , Svensson Christina , Eriksson Per , Sjöwall Christopher , Zachrisson Helene 
Published: July 2024

ObjectiveThe objective of this study was 2-fold: first, to evaluate whether superb microvascular imaging (SMI) could be used to visualize neovascularization in temporal arteries, and, second, to evaluate the diagnostic performance of high frequency ultrasound with SMI using an extended protocol in patients with suspected giant cell arteritis (GCA).MethodsThis retrospective study comprised 120 patients consecutively examined with an extended CDU protocol (temporal, facial, axillary, subclavian, brachiocephalic, and carotid arteries) between 2020 and 2022. Of all patients, 107 had no previous GCA diagnosis and 13 had a previous GCA diagnosis. SMI was used to evaluate neovascularization in the temporal arteries. Arteritis were characterized as low- or medium-echogenic, homogeneous wall thickening, with or without a positive compression sign in the temporal arteries. The Halo count, i.e., the number of temporal and axillary artery segments with signs of arteritis, was evaluated. The reference was clinically diagnosed GCA confirmed after ≥6-month follow-up.ResultsOf the eligible 107 patients with new suspected GCA, 33 (31%) received a clinical GCA diagnosis. Neovascularization was detected in 14 patients (43%). Patients with neovascularization displayed a higher halo count [median 6 (25th−75th percentile 4.75–7) vs. 3 (2-4-4), p = 0.005]. CDU of only the temporal arteries showed sensitivity and specificity (95% confidence intervals) of 94% (80–100%) and 100% (95–100%), respectively. The addition of extra-cranial arteries increased the sensitivity to 100%. Of the 13 patients investigated for suspected relapse, three had a clinically confirmed relapse. One of them displayed neovascularization together with other signs of inflammation.ConclusionsWe show for the first time that inflammatory neovascularization of the temporal arteries can be detected by SMI. Neovascularization is associated with a more-widespread cranial disease. The value of neovascularization should be further investigated, especially for the detection of GCA relapse.
Comparing similarities and differences between NAFLD, MAFLD, and MASLD in the general U.S. population
Authors: Zou Haoxuan , Ma Xiaopu , Pan Wen , Xie Yan 
Published: July 2024

BackgroundRecently, the multisociety Delphi consensus renamed non-alcoholic fatty liver disease (NAFLD) terminology [previously renamed metabolic-associated fatty liver disease (MAFLD)] as metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of this study was to compare the similarities and differences between NAFLD, MAFLD, and MASLD and to clarify the impact of this new name change.MethodsA cross-sectional study of 3,035 general subjects with valid vibration-controlled transient elastography data was conducted based on data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. NAFLD, MAFLD, and MASLD were defined according to the corresponding consensus criteria.ResultsUsing controlled attenuation parameter (CAP) ≥274 dB/m and liver stiffness measurements (LSM) ≥9.7 kPa as the cutoff values for the presence of hepatic steatosis and advanced liver fibrosis (ALF), the prevalence of NAFLD, MAFLD, and MASLD were 38.01% (95% CI 35.78–40.29%), 41.09% (39.09–43.12%), and 37.9% (35.70–40.14%), respectively, and the corresponding prevalence of ALF was 10.21% (7.09–14.48%), 10.13% (7.06-14.35%), and 10.24% (7.11–14.53%), respectively. The kappa values for the three definitions were above 0.9. The prevalence and severity of the three definitions remained similar when the sensitivity analyses were performed using different CAP thresholds. The prevalence of NAFLD, MAFLD, MASLD, and ALF increased as the number of cardiometabolic risk factors (CMRF) increased.ConclusionsOur findings highlight the consistency among the three definitions, especially between NAFLD and MASLD, so that the new consensus will not disturb the original NAFLD-related findings. Additionally, more attention should be paid to patients with a high number of CMRFs.
Efficacy and safety of first- versus second-generation Bruton tyrosine kinase inhibitors in chronic lymphocytic leukemia: a systematic review and meta-analysis
Authors: Ke Liyuan , Li Su , Huang Danxue , Wang Yan 
Published: July 2024

We conducted this first systematic review and meta-analysis to assess the competitive advantage of 2nd-generation Bruton tyrosine kinase inhibitors (BTKi) compared to 1st-generation BTKi in chronic lymphocytic leukemia (CLL). The literature search was conducted from PubMed, Web of Science, Embase databases, and hematology annual conferences. Data of over response rate (ORR), progression-free survival (PFS), and overall survival (OS) were extracted to a pool meta-analysis of efficacy; adverse events (AEs) were also extracted to a pool meta-analysis of safety. Bias risk assessment and meta-analysis were performed by Review Manager 5.3 and STATA 14 software. A total of 3649 patients from 29 cohorts were included. The results showed that the benefits of ORR and 24-month PFS in 2nd-generation BTKi compared to 1st-generation BTKi were not significant in the whole population but only in the relapsed or refractory (R/R) CLL patient subgroup (ORR: 86.4% vs. 76.2%, p = 0.013; 24-month PFS: 76.9% vs. 67.9%, p = 0.004). Any-grade AEs were comparable between 1st- and 2nd-generation BTKi, but grade 3 or higher AEs were significantly less frequent with 2nd-generation BTKi versus 1st-generation BTKi (grade 3 or higher: 53.1% vs. 72.5%; p = 0.002). Headache was more frequent with 2nd-generation BTKi, while diarrhea and atrial fibrillation were more frequent with 1st-generation BTKi. Only for patients with relapsed or refractory CLL did 2nd-generation BTKi have a competitive advantage, while adverse effects still need to be considered.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO, Identifier 42022342488.