bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes mellitus and corticotherapy as risk factors for alendronate‐related osteonecrosis of the jaws: A study in Wistar rats
Authors: Berti–Couto Soraya A. , Vasconcelos Ana Carolina U. , Iglesias Júlia E. , Figueiredo Maria Antonia Z. , Salum Fernanda G. , Cherubini Karen 
Published: May 2013

BackgroundThe purpose of this study was to investigate the influence of diabetes and corticotherapy on the development of osteonecrosis of the jaws associated with sodium alendronate.MethodsRats were allocated into 4 groups of 11 animals each, representing different treatments: (1) alendronate; (2) alendronate and corticotherapy; (3) alendronate and diabetes; and (4) control. Tooth extractions were performed in all animals, and histological analysis was performed by hematoxylin and eosin staining and immunohistochemistry using anti‐bone morphogenetic protein (BMP)‐4 and anti‐matrix metalloproteinase (MMP)‐13 antibodies.ResultsOn hematoxylin and eosin analysis, proportions of inflammatory infiltrate, microbial colonies, and osteonecrosis were significantly greater in the diabetes group. BMP‐4 expression in connective tissue was higher in the corticosteroid group than the alendronate group. There were no significant differences between the other groups. MMP‐13 expression did not differ between the groups analyzed.ConclusionDiabetes but not corticotherapy is associated with jaw osteonecrosis in rats undergoing alendronate therapy and subjected to tooth extractions. © 2013 Wiley Periodicals, Inc. Head Neck 36: 84–93, 2014
Spatial and temporal variations of albedo on nine glaciers in western China from 2000 to 2011
Authors: Wang Jie , Ye Baisheng , Cui Yuhuan , He Xiaobo , Yang Guojing 
Published: May 2013

AbstractThis research demonstrates the spatiotemporal variations of albedo on nine glaciers in western China during 2000–2011, by the albedo derived from two types of datasets: Landsat TM/ETM + images and MOD10A1 product. Then, the influence factors of glacier albedo and its relationship with glacier mass balance are also analyzed by the correlation approach, which is frequently used in geostatistics. The paper finds that there are different spatiotemporal variations over the glaciers in western China: (1) For a single glacier, the albedo varies gently with altitude on its tongue and increases fast in the middle part, while in the accumulation zones, the albedo value appears in the form of fluctuation. This could provide a quantitative method to retrieve the snowline by determining the threshold albedo value of snowpack and bare ice. (2) For the glaciers in western China, the albedo decreases with distance to the center of Tibetan Plateau (TP). This may relate to the elevation of glacier, for the speed of glacier retreat highly depends on air temperature. (3) In the summer period, albedo on most glaciers declines over the last 12 years, and it decreases much faster in southeastern TP than other regions, for which air temperature overwhelms the black carbon concentration. In addition, the trend of glacier albedo in summer is greatly correlated with that of measured glacier mass balance, which implies that the long‐term albedo datasets by remote sensing technology could be used to monitor and predict the change of glacier mass balance in the future. Copyright © 2013 John Wiley & Sons, Ltd.
The high hydraulic conductivity of three wooded tropical peat swamps in northeast Peru: measurements and implications for hydrological function
Authors: Kelly Thomas J. , Baird Andy J. , Roucoux Katherine H. , Baker Timothy R. , Honorio Coronado Eurídice N. , Ríos Marcos , Lawson Ian T. 
Published: May 2013

AbstractThe form and functioning of peatlands depend strongly on their hydrological status, but there are few data available on the hydraulic properties of tropical peatlands. In particular, the saturated hydraulic conductivity (K) has not previously been measured in neotropical peatlands. Piezometer slug tests were used to measure K at two depths (50 and 90 cm) in three contrasting forested peatlands in the Peruvian Amazon: Quistococha, San Jorge and Buena Vista. Measured K at 50 cm depth varies between 0.00032 and 0.11 cm s−1, and at 90 cm, it varies between 0.00027 and 0.057 cm s−1. Measurements of K taken from different areas of Quistococha showed that spatial heterogeneity accounts for ~20% of the within‐site variance and that depth is a good predictor of K. However, K did not vary significantly with depth at Buena Vista and San Jorge. Statistical analysis showed that ~18% of the variance in the K data can be explained by between‐site differences. Simulations using a simple hydrological model suggest that the relatively high K values could lead to lowering of the water table by >10 cm within ~48 m of the peatland edge for domed peatlands, if subjected to a drought lasting 30 days. However, under current climatic conditions, even with high K, peatlands would be unable to shed the large amount of water entering the system via rainfall through subsurface flow alone. We conclude that most of the water leaves these peatlands via overland flow and/or evapotranspiration. Copyright © 2013 John Wiley & Sons, Ltd.
Adipose tissue‐derived mesenchymal stem cells as monocultures or cocultures with human umbilical vein endothelial cells: Performancein vitroand in rat cranial defects
Authors: Ma Jinling , Both Sanne K. , Ji Wei , Yang Fang , Prins Henk‐Jan , Helder Marco N. , Pan Juli , Cui Fu‐Zhai , Jansen John A. , van den Beucken Jeroen J. P. 
Published: May 2013

AbstractThe aim of this study was to compare the osteogenic capacity between human adipose tissue‐derived mesenchymal stem cells (AT‐MSCs) and their cocultures with human umbilical vein endothelial cells (HUVECs)in vitroand their biological performancein vivo. First, the optimal cell ratio in cocultures for osteogenic differentiation was determined by seeding AT‐MSCs and HUVECs in ratios varying from 100:0 to 0:100 on tissue culture plates. Afterward, AT‐MSCs and AT‐MSCs/HUVECs (50:50) were seeded on porous titanium fiber mesh scaffolds (Ti) for bothin vitroandin vivoosteogenic evaluation. Forin vitroevaluation, cell osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity and calcium assay. Forin vivoevaluation, the scaffolds were implanted bilaterally into rat cranial defects (5 mm diameter) and bone formation was assessed histologically and histomorphometrically after 8 weeks. The ratio of 50:50 was chosen in the cocultures because this coculture condition retained similar amount of calcium deposition while using the least amount of AT‐MSCs. Moreover, AT‐MSCs showed higher osteogenic differentiation in comparison to AT‐MSCs/HUVECs on Tiin vitro. Furthermore, superior bone formation was observed in AT‐MSCs compared to AT‐MSCs/HUVECs in rat cranial defects. In conclusion, AT‐MSCs showed significantly higher osteogenic potential compared to AT‐MSCs/HUVECs bothin vitroandin vivo. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1026–1036, 2014.
Ultrastructure investigation of the secondary insemination system of the gamasid mite Hattena cometis domrow (Acari: Anactinotrichida: Ameroseiidae)
Authors: Di Palma Antonella , Seeman Owen , Alberti Gerd 
Published: May 2013

ABSTRACTMany gamasid mites, mainly of the taxon Dermanyssina, possess a secondarily evolved insemination system that is generally described as occurring in two types, the laelapid and the phytoseiid‐type, which are structurally considerably different. Considering that Dermanyssina represent the most recent and most diverse group of gamasid mites, it was expected that a greater diversity of insemination system than reflected by the two types could be present and could give an idea of its evolution within the taxon. Here, the authors present a description of the fine‐structure of the female secondary insemination system in the dermanyssine mite Hattena cometis. The system consists of a pair of sperm induction pores (solenostomes) and short sperm access ducts (tubules) which end in a syncytium. The syncytial strands of both sides meet medially under the ovary s.str., where they form a spherical syncytial spermatheca. Mature sperm cells of a modified ribbon type were seen in the syncytial parts of the system. The insemination system of Hattena cometis is regarded as a modification of the laelapid type. However, it is much simpler than that of Varroa destructor, the only other gamasid mite with the laelapid type studied ultrastructurally until now, and shows also some structural differences (e.g., no presence of an unpaired sperm duct). Hence, the present study suggests that some intermediate types might be revealed in future ultrastructure studies representing steps in the evolution of the insemination system in the Dermanyssina. J. Morphol. 274:918–925, 2013. © 2013 Wiley Periodicals, Inc.
Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration
Authors: Antoniou John , Epure Laura M. , Michalek Arthur J. , Grant Michael P. , Iatridis James C. , Mwale Fackson 
Published: May 2013

PurposeTo establish relationships between quantitative MRI (qMRI) and biomechanical parameters in order to help inform and interpret alterations of human intervertebral discs (IVD) with different grades of degeneration.Materials and MethodsThe properties of the nucleus pulposus (NP) and annulus fibrosus (AF) of each IVD of 10 lumbar spines (range, 32–77 years) were analyzed by qMRI (relaxation times T1 and T2, magnetization transfer ratio [MTR], and apparent diffusion coefficient [ADC]), and tested in confined compression and dynamic shear.ResultsT1 and T2 significantly decreased in both the NP and AF with increasing degeneration grades while the MTR increased significantly with grade 4. In contrast to the other qMRI parameters, the ADC had a tendency to decrease with increasing grade. Disc degeneration caused a decrease in the aggregate modulus, hydraulic permeability and shear modulus magnitude along with an increase in phase angle in the AF. In contrast, disc degeneration of NPs demonstrated decreases in shear modulus and phase angle.ConclusionOur studies indicate that qMRI can be used as a noninvasive diagnostic tool in the detection of IVD properties with the potential to help interpret and detect early, middle, and late stages of degeneration. QMRI of human IVD can therefore become a very important diagnostic assessment tool in determining the functional state of the disc. J. Magn. Reson. Imaging 2013;38:1402–1414. © 2013 Wiley Periodicals, Inc.
Top‐down HPLC–ESI‐MS characterization of rat gliadoralin A, a new member of the family of rat submandibular gland glutamine‐rich proteins and potential substrate of transglutaminase
Authors: Cabras Tiziana , Iavarone Federica , Pirolli Davide , Cristina De Rosa Maria , Vitali Alberto , Faa Gavino , Cordaro Massimo , Messana Irene , Ekström Jörgen , Castagnola Massimo 
Published: May 2013

During HPLC–ESI‐MS/MS analysis of rat submandibular saliva secreted under isoprenaline stimulation, a protein with an experimental [M+H]1+ = 10 544.24 m/z was detected (17.5 ± 0.7 min). The MS/MS fragmentation pattern, manually investigated, allowed establishing an internal sequence in agreement with a DNA‐derived sequence of an unknown rat protein coded D3Z9M3 (Swiss‐Prot). To match the experimental MS/MS fragmentation pattern and protein mass with theoretical data, the removal from the N terminus of the signal peptide and from the C terminus of three amino acid (a.a.) residues (Arg‐Ala‐Val) and the cyclization of the N‐terminal glutamine in pyroglutamic had to be supposed, resulting in a mature protein of 90 a.a. HPLC–ESI‐MS/MS of the trypsin digest ensured 100% sequence coverage. For the high glutamine content (34/90 = 37.8%) we propose to name this protein rat gliadoralin A 1–90. Low amounts of five different isoforms were sporadically detected, which did not significantly change their relative amounts after stimulation. Gliadoralin A is substrate for transglutaminase‐2, having Lys 60 and different Gln residues as major determinants for enzyme recognition. In silico investigation of superior structures evidenced that a small part of the protein adopts an α‐helical fold, whereas large segments are unfolded, suggesting an unordered conformation.
Find and Irradiate — Lasers Used for Weed Control
Authors: Kaierle Stefan , Marx Christian , Rath Thomas , Hustedt Michael 
Published: May 2013

AbstractDue to their outstanding properties, interest in lasers has increased greatly in precision agriculture as a potential tool for non‐chemical weed control. unwanted plants have a negative effect on crop growth, especially in close surroundings. Weed control based on mechanical (e.g. hoeing) or thermal (flaming) methods do not meet the precision requirements to preserve crop plants. An innovative combination of image processing and laser technology is promising.
Cerebral TOF angiography at 7T: Impact of B1+ shimming with a 16‐channel transceiver array
Authors: Schmitter Sebastian , Wu Xiaoping , Adriany Gregor , Auerbach Edward J. , Uğurbil Kâmil , Van de Moortele Pierre‐François 
Published: May 2013

PurposeTime‐of‐flight (TOF) MR imaging is clinically among the most common cerebral noncontrast enhanced MR angiography techniques allowing for high spatial resolution. As shown by several groups TOF contrast significantly improves at ultrahigh field of B0 = 7T, however, spatially varying transmit B1 (B1+) fields at 7T reduce TOF contrast uniformity, typically resulting in suboptimal contrast and reduced vessel conspicuity in the brain periphery.MethodsUsing a 16‐channel B1+ shimming system, we compare different dynamically applied B1+ phase shimming approaches on the radiofrequency excitation to improve contrast homogeneity for a (0.5 mm)3 resolution multislab TOF acquisition. In addition, B1+ shimming applied on the venous saturation pulse was investigated to improve venous suppression, subcutaneous fat signal reduction and enhanced background suppression originating from MT effect.ResultsB1+ excitation homogeneity was improved by a factor 2.2–2.6 on average depending on the shimming approach, compared to a standard CP‐like phase setting, leading to improved vessel conspicuity particularly in the periphery. Stronger saturation, higher fat suppression and improved background suppression were observed when dynamically applying B1+ shimming on the venous saturation pulse.ConclusionB1+ shimming can significantly improve high resolution TOF vascular investigations at ultrahigh field, holding strong promise for non contrast‐enhanced clinical applications. Magn Reson Med 71:966–977, 2014. © 2013 Wiley Periodicals, Inc.
Detection of in vivo enzyme activity with CatalyCEST MRI
Authors: Yoo Byunghee , Sheth Vipul R. , Howison Christine M. , Douglas Matthew J. K. , Pineda Carlos T. , Maine Erin A. , Baker Amanda F. , Pagel Mark D. 
Published: May 2013

PurposeCatalyCEST MRI compares the detection of an enzyme‐responsive chemical exchange saturation transfer (CEST) agent with the detection of an unresponsive “control” CEST agent that accounts for other conditions that influence CEST. The purpose of this study was to investigate the feasibility of in vivo catalyCEST MRI.MethodsCEST agents that were responsive and unresponsive to the activity of urokinase plasminogen activator were shown to have negligible interaction with each other. A CEST‐fast imaging with steady state precession (FISP) MRI protocol was used to acquire MR CEST spectroscopic images with a Capan‐2 pancreatic tumor model after intravenous injection of the CEST agents. A function of (super)‐Lorentzian line shapes was fit to CEST spectra of a region‐of‐interest that represented the tumor.ResultsThe CEST effects from each agent showed the same initial uptake into tumor tissues, indicating that both agents had the same pharmacokinetic transport rates. Starting 5 min after injection, CEST from the enzyme‐responsive agent disappeared more quickly than CEST from the unresponsive agent, indicating that the enzyme responsive agent was being catalyzed by urokinase plasminogen activator, while both agents also experienced net pharmacokinetic washout from the tumor.ConclusionCatalyCEST MRI demonstrates that dynamic tracking of enzyme‐responsive and unresponsive CEST agents during the same in vivo MRI study is feasible. Magn Reson Med 71:1221–1230, 2014. © 2013 Wiley Periodicals, Inc.
A differential pattern of gene expression in skeletal muscle of tumor‐bearing rats reveals dysregulation of excitation–contraction coupling together with additional muscle alterations
Authors: Fontes‐Oliveira Cibely Cristine , Busquets Sílvia , Fuster Gemma , Ametller Elisabet , Figueras Maite , Olivan Mireia , Toledo Míriam , López‐Soriano Francisco J. , Qu Xiaoyan , Demuth Jeffrey , Stevens Paula , Varbanov Alex , Wang Feng , Isfort Robert J. , Argilés Josep M. 
Published: May 2013

ABSTRACTIntroduction: Cachexia is a wasting condition that manifests in several types of cancer. The main characteristic of this condition is a profound loss of muscle mass. Methods: By using a microarray system, expression of several hundred genes was screened in skeletal muscle of rats bearing a cachexia‐inducing tumor, the AH‐130 Yoshida ascites hepatoma. This model induced a strong decrease in muscle mass in the tumor‐bearing animals, as compared with their healthy counterparts. Results: The results show important differences in gene expression in EDL skeletal muscle between tumor‐bearing animals with cachexia and control animals. Conclusions: The differences observed pertain to genes related to intracellular calcium homeostasis and genes involved in the control of mitochondrial oxidative phosphorylation and protein turnover, both at the level of protein synthesis and proteolysis. Assessment of these differences may be a useful tool for the design of novel therapeutic strategies to fight this devastating syndrome. Muscle Nerve 49: 233–248, 2014
Muscle‐related differences in mechanomyography–force relationships are model‐dependent
Authors: Cooper Michael A. , Herda Trent J. 
Published: May 2013

ABSTRACTIntroduction: In this study we examined the mechanomyographic amplitude (MMGRMS)–force relationships with log‐transform and polynomial regression models for the vastus lateralis (VL), rectus femoris (RF), and first dorsal interosseous (FDI) muscles. Methods: Twelve healthy (age 23 ± 3 years) men performed isometric ramp contractions of the leg extensors and index finger from 10% to 80% of their maximal voluntary contraction (MVC) with MMG sensors positioned on the VL, RF, and FDI. Log‐transform and polynomial regression models were fitted to the relationships. Results: There were differences for the a terms (intercepts) and b terms (slopes) from the log‐transform model between the FDI, VL, and RF; however, there were no consistent differences identified with the polynomial regression models. Conclusions: The log‐transform model quantified differences in the patterns of responses between the FDI and the leg extensors, but polynomial regression could not distinguish such differences. Muscle Nerve 49: 202–208, 2014
Homogenization of anisotropic elastoplastic behaviors of a porous polycrystal with interface effects
Authors: He Z. , Caratini G. , Dormieux L. , Kondo D. 
Published: May 2013

SUMMARYThis paper is devoted to develop a theoretical framework to predict the macroscopic transversely isotropic elastoplastic behavior of clay‐like material, which is viewed as a porous polycrystal. We consider evolutions of two local plastic mechanisms of grains and interface simultaneously, for which a Schmid criterion is used for the strength of sheet‐like grains and a Tresca criterion for the strength of interfaces between particles. By adapting the standard incremental method, we propose firstly a classic self‐consistent model, which does not consider the effect of interface, then a generalized self‐consistent model in which the solid phase is represented by laminated (or isotropic) spherical grains surrounded by interfaces. Comparisons of numerical predictions between these two methods are performed and have demonstrated the validity of the generalized self‐consistent model taking account of interface effects. Numerical simulations of uniaxial compression tests have shown that the macroscopic elastoplastic behavior of polycrystalline (clay‐like) material can be successfully predicted by the way of considering the two local plastic mechanisms at microscopic scale. Copyright © 2013 John Wiley & Sons, Ltd.
Chemically Polymerization Mechanism of Aromatic Compounds under Atmospheric Pressure Plasma Conditions
Authors: Asandulesa Mihai , Topala Ionut , Pohoata Valentin , Legrand Yves Marie , Dobromir Marius , Totolin Marian , Dumitrascu Nicoleta 
Published: May 2013

AbstractThe multitude of chemically reactive species that are involved in plasma polymerization process make difficult to anticipate how the polymer will look like. In order to prepare polymerized films with imposed properties a good control over the plasma polymerization reaction should be done. In this paper, we investigate plasma polymerization reactions of aromatic compounds using a cold atmospheric pressure glow discharge working in helium. The structure of polymerized films was determined using infrared spectroscopy, X‐ray photoelectron spectroscopy, and nuclear magnetic resonance spectroscopy. Furthermore, the results of spectroscopic analyses allowed us to develop a polymerization mechanism from a chemical point of view related to formation of plasma‐polymerized films. magnified image
Preparation and Characterization of Insensitive HMX/Graphene Oxide Composites
Authors: Li Rui , Wang Jun , Shen Jin Peng , Hua Cheng , Yang Guang Cheng 
Published: May 2013

AbstractTo improve the safety of HMX, a two‐dimensional (2D) graphene oxide (GO) was introduced to HMX by the solventnonsolvent method. The morphology, composition, thermal decomposition characteristic were characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), thermogravimetry (TG) and differential scanning calorimetry (DSC). Compared to the previous reports, GO sheets exhibited better desensitizing effect than [60]Fullerene and CNTs. When 2.0 wt‐% GO sheets were added, the impact sensitivity of raw HMX decreased from 100 to 10 %, and the friction sensitivity reduced from 100 to 32 %. The DSC results proved that GO sheets were compatible with HMX. In addition, by determining the thermal decomposition kinetic parameters of the samples, it was found that the activation energy (Ea) of HMX with 2.0 wt‐% GO increased by 23.5 kJ mol−1, suggesting that GO sheets could improve the thermal stability of HMX.