bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats
Authors: Ptilovanciv Ellen ON , Fernandes Gabryelle S , Teixeira Luciana C , Reis Luciana A , Pessoa Edson A , Convento Marcia B , Simões Manuel J , Albertoni Guilherme A , Schor Nestor , Borges Fernanda T 
Published: January 2013

Abstract
One important concern in the treatment of diabetes is the maintenance of glycemic levels and the prevention of diabetic nephropathy. Inducible heme oxygenase 1 (HO-1) is a rate-limiting enzyme thought to have antioxidant and cytoprotective roles. The goal of the present study was to analyze the effect of HO-1 induction in chronically hyperglycemic rats. The hyperglycemic rats were divided into two groups: one group, called STZ, was given a single injection of streptozotocin; and the other group was given a single streptozotocin injection as well as daily injections of hemin, an HO-1 inducer, over 60 days (STZ + HEME). A group of normoglycemic, untreated rats was used as the control (CTL).
Body weight, diuresis, serum glucose levels, microalbuminuria, creatinine clearance rate, urea levels, sodium excretion, and lipid peroxidation were analyzed. Histological alterations and immunohistochemistry for HO-1 and inducible nitric oxide synthase (iNOS) were assessed. After 60 days, the STZ group exhibited an increase in blood glucose, diuresis, urea, microalbuminuria, and sodium excretion. There was no weight gain, and there was a decrease in creatinine clearance in comparison to the CTL group. In the STZ + HEME group there was an improvement in the metabolic parameters and kidney function, a decrease in blood glucose, serum urea, and microalbuminuria, and an increase of creatinine clearance, in comparison to the STZ group.
There was glomerulosclerosis, collagen deposition in the STZ rats and increase in iNOS and HO-1 expression. In the STZ + HEME group, the glomerulosclerosis and fibrosis was prevented and there was an increase in the expression of HO-1, but decrease in iNOS expression and lipid peroxidation. In conclusion, our data suggest that chronic induction of HO-1 reduces hyperglycemia, improves glucose metabolism and, at least in part, protects the renal tissue from hyperglycemic injury, possibly through the antioxidant activity of HO-1.
Structural health monitoring of a cantilever beam using support vector machine
Authors: Satpal Satish B , Khandare Yogesh , Guha Anirban , Banerjee Sauvik 
Published: January 2013

Abstract
In this article, the effectiveness of support vector machine (SVM) is examined for health monitoring of beam-like structures using vibration-induced modal displacement data. The SVM is used to predict the intensity or location of damage in a simulated cantilever beam from displacements of the first mode shape. Twelve levels of damage intensities have been simulated at 12 locations, and six levels of white Gaussian noise have been added, thereby obtaining 1,008 simulations. About 90% of these are used for training the SVM, and the remaining are used for testing. The trained SVM is able to predict damage intensity and location of all the training set data with nearly 100% accuracy. The test set data reveal that SVM is able to predict damage intensity and damage location with errors varying from 0.28% to 4.57% and 0% to 20.3%, respectively, when there is no noise in the data. Addition of noise degrades the performance of SVM, the degradation being significant for intensity prediction and less for damage location prediction. The results demonstrate the use of SVM as a powerful tool for structural health monitoring without using the data of healthy state.
Lung cancer screening: from imaging to biomarker
Authors: Xiang Dong , Zhang Bicheng , Doll Donald , Shen Kui , Kloecker Goetz , Freter Carl 
Published: January 2013

Abstract
Despite several decades of intensive effort to improve the imaging techniques for lung cancer diagnosis and treatment, primary lung cancer is still the number one cause of cancer death in the United States and worldwide. The major causes of this high mortality rate are distant metastasis evident at diagnosis and ineffective treatment for locally advanced disease. Indeed, approximately forty percent of newly diagnosed lung cancer patients have distant metastasis. Currently, the only potential curative therapy is surgical resection of early stage lung cancer. Therefore, early detection of lung cancer could potentially increase the chance of cure by surgery and underlines the importance of screening and detection of lung cancer. In the past fifty years, screening of lung cancer by chest X-Ray (CXR), sputum cytology, computed tomography (CT), fluorescence endoscopy and low-dose spiral CT (LDCT) has not improved survival except for the recent report in 2010 by the National Lung Screening Trial (NLST), which showed a 20 percent mortality reduction in high risk participants screened with LDCT compared to those screened with CXRs. Furthermore, serum biomarkers for detection of lung cancer using free circulating DNA and RNA, exosomal microRNA, circulating tumor cells and various lung cancer specific antigens have been studied extensively and novel screening methods are being developed with encouraging results. The history of lung cancer screening trials using CXR, sputum cytology and LDCT, as well as results of trials involving various serum biomarkers, are reviewed herein.
Kinetic modeling: a predictive tool for the adsorption of zinc ions onto calcium alginate beads
Authors: Kafshgari Morteza Hasanzadeh , Mansouri Mohsen , Khorram Mohammad , Kashani Shahab Rahimi 
Published: January 2013

Abstract

Background
The main purpose of this study is to develop a nonlinear model of a batch adsorption and to evaluate the model's capability in the prediction of experimental adsorption data. Additionally, results of the nonlinear model were compared with data of pseudo first- and second-order models. Experimental data were extracted from the adsorption of zinc ions using calcium alginate beads prepared via electrospray method. In order to study the effects of biosorbent porosity and the initial concentration of the zinc solution on adsorption kinetics, calcium alginate beads were prepared with two different porosities and zinc concentrations.

Results
The results revealed that the nonlinear model offers a much more accurate prediction compared with other models as the average root mean square deviation of the nonlinear model was calculated to be only 2.66%, which was smaller at least four times than that of others. Furthermore, the nonlinear model showed that diffusive transport through beads was limited by pore diffusion.

Conclusions
The nonlinear model provided a good fit to the experimental data as the calculated equilibrium adsorptions were shown to be in good agreement with their experimental counterparts.
18F-florbetaben Aβ imaging in mild cognitive impairment
Authors: Ong Kevin , Villemagne Victor L , Bahar-Fuchs Alex , Lamb Fiona , Chételat Gaël , Raniga Parnesh , Mulligan Rachel S , Salvado Olivier , Putz Barbara , Roth Katrin , Masters Colin L , Reininger Cornelia B , Rowe Christopher C 
Published: January 2013

Abstract
Introduction
18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).

Methods
Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.

Results
High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden.

Conclusion
Higher Aβ deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit μ1A
Authors: Radhakrishnan Karthikeyan , Baltes Jennifer , Creemers John W. M. , Schu Peter 
Published: January 2013

Summary
The AP-1 complex recycles between membranes and the cytoplasm and dissociates from membranes during clathrin-coated-vesicle uncoating, but also independently of vesicular transport. The μ1A N-terminal 70 amino acids are involved in regulating AP-1 recycling. In a yeast two-hybrid library screen we identified the cytoplasmic prolyl-oligopeptidase-like protein PREPL as an interaction partner of this domain. PREPL overexpression leads to reduced AP-1 membrane binding, whereas reduced PREPL expression increases membrane binding and impairs AP-1 recycling. Altered AP-1 membrane binding in PREPL-deficient cells mirrors the membrane binding of the mutant AP-1* complex, which is not able to bind PREPL. Colocalisation of PREPL with residual membrane-bound AP-1 can be demonstrated. Patient cell lines deficient in PREPL have an expanded trans-Golgi network, which could be rescued by PREPL expression. These data demonstrate PREPL as an AP-1 effector that takes part in the regulation of AP-1 membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney. Its deficiency causes hypotonia and growth hormone hyposecretion, supporting essential PREPL functions in AP-1-dependent secretory pathways.
Chk1 and Mps1 jointly regulate correction of merotelic kinetochore attachments
Authors: Petsalaki Eleni , Zachos George 
Published: January 2013

Summary
If uncorrected, merotelic kinetochore attachments can induce mis-segregated chromosomes in anaphase. We show that checkpoint kinase 1 (Chk1) protects vertebrate cells against merotelic attachments and lagging chromosomes and is required for correction of merotelic attachments during a prolonged metaphase. Decreased Chk1 activity leads to hyper-stable kinetochore microtubules, unstable binding of MCAK, Kif2b and Mps1 to centromeres or kinetochores and reduced phosphorylation of Hec1 by Aurora-B. Phosphorylation of Aurora-B at serine 331 (Ser331) by Chk1 is high in prometaphase and decreases significantly in metaphase cells. We propose that Ser331 phosphorylation is required for optimal localization of MCAK, Kif2b and Mps1 to centromeres or kinetochores and for Hec1 phosphorylation. Furthermore, inhibition of Mps1 activity diminishes initial recruitment of MCAK and Kif2b to centromeres or kinetochores, impairs Hec1 phosphorylation and exacerbates merotelic attachments in Chk1-deficient cells. We propose that Chk1 and Mps1 jointly regulate Aurora-B, MCAK, Kif2b and Hec1 to correct merotelic attachments. These results suggest a role for Chk1 and Mps1 in error correction.
Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis
Authors: Cuny Thomas , Pertuit Morgane , Sahnoun-Fathallah Mona , Daly Adrian , Occhi Gianluca , Odou Marie Françoise , Tabarin Antoine , Nunes Marie Laure , Delemer Brigitte , Rohmer Vincent , Desailloud Rachel , Kerlan Véronique , Chabre Olivier , Sadoul Jean-Louis , Cogne Muriel , Caron Philippe , Cortet-Rudelli Christine , Lienhardt Anne , Raingeard Isabelle , Guedj Anne-Marie , Brue Thierry , Beckers Albert , Weryha Georges , Enjalbert Alain , Barlier Anne 
Published: January 2013

ContextGermline mutations in the aryl hydrocarbon receptor interacting protein gene (AIP) have been identified in young patients (age ≤30 years old) with sporadic pituitary macroadenomas. Otherwise, there are few data concerning the prevalence of multiple endocrine neoplasia type 1 (MEN1) mutations in such a population.ObjectiveWe assessed the prevalence of both AIP and MEN1 genetic abnormalities (mutations and large gene deletions) in young patients (age ≤30 years old) diagnosed with sporadic and isolated macroadenoma, without hypercalcemia and/or MEN1-associated lesions.DesignThe entire coding sequences of AIP and MEN1 were screened for mutations. In cases of negative sequencing screening, multiplex ligation-dependent probe amplification was performed for the detection of large genetic deletions.Patients and settingsOne hundred and seventy-four patients from endocrinology departments of 15 French University Hospital Centers were eligible for this study.ResultsTwenty-one out of 174 (12%) patients had AIP (n=15, 8.6%) or MEN1 (n=6, 3.4%) mutations. In pediatric patients (age ≤18 years old), AIP/MEN1 mutation frequency reached nearly 22% (n=10/46). AIPmut and MEN1mut were identified in 8/79 (10.1%) and 1/79 (1.2%) somatotropinoma patients respectively; they each accounted for 4/74 (5.4%) prolactinoma (PRL) patients with mutations. Half of those patients (n=3/6) with gigantism displayed mutations in AIP. Interestingly, 4/12 (33%) patients with non-secreting adenomas bore either AIP or MEN1 mutations, whereas none of the eight corticotroph adenomas or the single thyrotropinoma case had mutations. No large gene deletions were observed in sequencing-negative patients.ConclusionMutations in MEN1 can be of significance in young patients with sporadic isolated pituitary macroadenomas, particularly PRL, and together with AIP, we suggest genetic analysis of MEN1 in such a population.
CdS and ZnS Nanoparticles Growth in Different Reaction Media: Synthesis and Characterization
Authors: Antolini F. , Trave E. , Mirenghi L. , Re M. , Mattei G. , Tapfer L. , Mazzoldi P. 
Published: January 2013

AbstractIn this work we report on the growth of cadmium sulfide and zinc sulfide nanocrystals by thermolysis, starting from a metal thiolate in a (i) solventless way, (ii) by a novel route in tryoctilphosphine oxide (TOPO), and (iii) by direct synthesis in a polystyrene matrix. The x-ray diffraction (XRD) and transmission electron microscopy (TEM) show that the nanocrystals fabricated by the different methods are under optimized growth conditions single crystals of zincblende structure and of regular spherical shape. The average size was estimated to be between 2.0-3.0 nm with a size dispersion that depends on the synthesis route and is in the range between 10% and 20%. The XPS results indicate that for the nanoparticles obtained via solventless strategy the sulfur is present both as bonded to the metal atom and to the organic residue, while in the TOPO synthesized nanoparticles the sulfur signal has only one component associated to the metal-sulfide bond. The photoluminescence spectroscopy (PL) analysis of CdS crystals clearly evidences the typical emissions of nanosized zincblende CdS monocrystalline particles. Furthermore, the optical spectroscopy data indicate that the size distribution of the Cdsulfide - TOPO nanoparticles seems to be generally larger than that ones grown directly in polymer matrix. For all the CdS samples, the metal-sulfide nanocrystals exhibit a trap-related radiative transition at about 2eV that can be attributed to the hole-electron recombination at particle surface defect-center.
Female Auditors and Accruals Quality
Authors: Ittonen Kim , Vähämaa Emilia , Vähämaa Sami 
Published: January 2013

SYNOPSIS
This paper examines the association between accruals quality and the gender of the firm's audit engagement partner. In particular, given the documented gender-based differences in diligence, conservatism, and risk tolerance, we postulate that female auditors may improve accruals quality. Using a sample of Finnish and Swedish NASDAQ OMX-listed firms, we run several alternative panel regressions of abnormal accruals on female auditor variables and firm-specific controls. The results suggest that firms with female audit engagement partners are associated with smaller abnormal accruals, thereby implying that female auditors may have a constraining effect on earnings management. In general, our findings indicate that the behavioral differences between women and men may have important implications for the quality of auditing and financial reporting.
Data Availability: The data used in this paper are derived from public sources.
Glaciological twins: basally controlled subglacial and supraglacial lakes
Authors: Sergienko Olga V. 
Published: January 2013

AbstractSubglacial lakes beneath ice streams of Antarctica and supraglacial lakes observed on the flanks of the Greenland ice sheet may seem to be unrelated. The former derive their water from energy dissipation associated with basal friction, the latter from atmospherically driven surface melting. However, using numerical models of ice and water flow, it is shown here that they share a common relationship to basal conditions that implies that surface lakes (or depressions that could host lakes under warmer atmospheric conditions) and basal lakes might exist in tandem.
Mechanical properties of snow using indentation tests: size effects
Authors: Huang Daisy , Lee Jonah H. 
Published: January 2013

AbstractAn attempt is made to obtain and quantify the mechanical properties of two common types of seasonal snow on the ground. Different samples of natural snow whose metamorphism had stabilized (such as would remain on a road throughout winter in a cold, snowy area) were gathered and tested using mesoscale indentation tests (metrics on the order of mm to cm). Results from the stress vs displacement curves from indentation indicated that (1) first peak strength decreased, according to a power law, with increasing indenter size and was not affected by snow average grain size, (2) plateau strength decreased with increasing indenter size, and snow compaction strength might be calculated from these data, and (3) mean energy absorption density during indentation was independent of indenter size in some size ranges, and decreased with increasing indenter size in other size ranges.
Evolution of crystal orientation in snow during temperature gradient metamorphism
Authors: Riche Fabienne , Montagnat Maurine , Schneebeli Martin 
Published: January 2013

AbstractThe physical properties of snow are tied to its microstructure. Especially for the slow, plastic deformation of snow and firn, the crystal orientation is an important factor in addition to the geometry of the ice matrix. While micro-computed tomography measures the snow microstructure precisely, it gives no information about the orientation of the ice crystals. In this study, we applied a temperature gradient of 50 K m−1 to large blocks of undisturbed decomposed snow and sieved snow during 3 months. The mean temperature of the snow samples during the temperature gradient experiment was −20°C. Two closely spaced snow samples were taken before the experiment, then every week during the first month and afterwards every month. From each sampling, one sample was analyzed by micro-computed tomography and the other was used for thin sections. The orientation of the c-axis was measured in the thin sections using an automatic ice texture analyzer. Initial density was 30% higher in the sieved snow sample. Density and specific surface area evolved alike, while the fabric showed a different evolution between the two samples. The undisturbed snow evolved from a weak single-maximum fabric towards a weak girdle fabric, while the sieved sample showed no evolution. The undisturbed snow sample converged toward the sieved sample fabric after 6 weeks, but continued its evolution thereafter. We suggest that the main factor causing this different behavior is the difference in density and in pore size.
Characterizing the glaciological conditions at Halvfarryggen ice dome, Dronning Maud Land, Antarctica
Authors: Drews Reinhard , Martín Carlos , Steinhage Daniel , Eisen Olaf 
Published: January 2013

AbstractWe present a comprehensive approach (including field data, remote sensing and an anisotropic ice-flow model) to characterize Halvfarryggen ice dome in coastal Dronning Maud Land, Antarctica. This is a potential drill site for the International Partnerships in Ice Core Sciences, which has identified the need for ice cores covering atmospheric conditions during the last few millennia. We derive the surface topography, the ice stratigraphy from radar data, and accumulation rates which vary from 400 to 1670 kg m−2 a−1 due to preferred wind directions and changing surface slope. The stratigraphy shows anticlines and synclines beneath the divides. We transfer Dansgaard–Johnsen age–depth scales from the flanks along isochrones to the divide in the upper 20–50% of the ice thickness and show that they compare well with the results of a full-Stokes, anisotropic ice-flow model which predicts (1) 11 ka BP ice at 90% of the ice thickness, (2) a temporally stable divide for at least 2700–4500 years, (3) basal temperatures below the melting point (−12°C to −5°C) and (4) a highly developed crystal orientation fabric (COF). We suggest drilling into the apices of the deep anticlines, providing a good compromise between record length and temporal resolution and also facilitating studies of the interplay of anisotropic COF and ice flow.
Tocilizumab Inhibits Structural Joint Damage and Improves Physical Function in Patients with Rheumatoid Arthritis and Inadequate Responses to Methotrexate: LITHE Study 2-year Results
Authors: FLEISCHMANN ROY M. , HALLAND ANNE-MARIE , BRZOSKO MAREK , BURGOS-VARGAS RUBEN , MELA CHRISTOPHER , VERNON EMMA , KREMER JOEL M. 
Published: January 2013

Objective.To assess radiographic progression, physical function, clinical disease activity, and safety in patients with rheumatoid arthritis (RA) who had inadequate response to methotrexate (MTX) and who were treated with tocilizumab-MTX or MTX during Year 2 of a 2-year study.Methods.During Year 1, patients were randomized to placebo-MTX, 4 mg/kg tocilizumab-MTX, or 8 mg/kg tocilizumab-MTX. During Year 2, patients continued the initial double-blind treatment or switched to open-label 8 mg/kg tocilizumab-MTX. Co-primary endpoints at Week 104 were mean change from baseline in Genant-modified Total Sharp Score (GmTSS) and adjusted mean area under the curve (AUC) for change from baseline in the Health Assessment Questionnaire–Disability Index (HAQ-DI). Signs and symptoms of RA and safety were also evaluated.Results.At Week 104, mean change from baseline in GmTSS was significantly lower for patients initially randomized to tocilizumab-MTX 4 mg/kg (0.58; p = 0.0025) or 8 mg/kg (0.37; p < 0.0001) than for patients initially randomized to placebo-MTX (1.96). Adjusted mean AUC of change from baseline in HAQ-DI was also significantly lower in patients initially randomized to tocilizumab-MTX 4 mg/kg (–287.5; p < 0.0001) or 8 mg/kg (–320.8; p < 0.0001) than in patients initially randomized to placebo-MTX (–139.4). Signs and symptoms of RA were maintained or showed improvement. No new safety signals were noted.Conclusion.Compared with placebo-MTX, tocilizumab-MTX significantly inhibited structural joint damage and improved physical function in patients with RA who previously had inadequate response to MTX. An extension of this study is continuing and will provide additional longterm efficacy and safety data. National Clinical Trials registry NCT00106535.