bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cantharidin represses invasion of pancreatic cancer cells
through accelerated degradation of MMP2 mRNA
Authors: Shen Meng , Wu Meng-Yao , Chen Long-Pei , Zhi Qiaoming , Gong Fei-Ran , Chen Kai , Li Dao-Ming , Wu Yadi , Tao Min , Li Wei 
Published: July 2015

AbstractCantharidin is an active constituent of mylabris, a traditional Chinese medicine
and is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays
an important role in cell cycle control, apoptosis and cell-fate determination. In
the present study, we found that cantharidin repressed the invasive ability of
pancreatic cancer cells and downregulated matrix metalloproteinase 2 (MMP2)
expression through multiple pathways, including ERK, JNK, PKC, NF-κB and β-catenin.
Interestingly, transcriptional activity of the MMP2 promoter increased after
treatment with PP2A inhibitors, suggesting the involvement of a posttranscriptional
mechanism. By using an mRNA stability assay, we found accelerated degradation of
MMP2 mRNA after treatment of cantharidin. Microarray analyses revealed that multiple
genes involved in the 3'→5' decay pathway were upregulated, especially genes
participating in cytoplasmic deadenylation. The elevation of these genes were
further demonstrated to be executed through ERK, JNK, PKC, NF-κB and β-catenin
pathways. Knockdown of PARN, RHAU and CNOT7, three critical members involved in
cytoplasmic deadenylation, attenuated the downregulation of MMP2. Hence, we present
the mechanism of repressed invasion by cantharidin and other PP2A inhibitors through
increased degradation of MMP2 mRNA by elevated cytoplasmic deadenylation.
The embodied mind: when biology meets culture and society
Authors: Bondebjerg Ib 
Published: July 2015

AbstractSince the 1980s the study of the brain has developed from being a primarily biological field to a significant interdisciplinary area with a strong influence on the humanities and social sciences. In this article I describe fundamental elements in what I call the embodied mind paradigm, and new understanding of the relation between mind, body and emotions. The new paradigm challenges certain notions of constructivism in the humanities and social sciences, but also opens up fruitful venues for new interdisciplinary research. Here I outline such possibilities in the particular areas of linguistics, philosophy, sociology and film studies. This article is published as part of an ongoing collection dedicated to interdisciplinary research.
A lipid switch unlocks Parkinson’s disease-associated ATP13A2
Authors: Holemans Tine , Sørensen Danny Mollerup , van Veen Sarah , Martin Shaun , Hermans Diane , Kemmer Gerdi Christine , Van den Haute Chris , Baekelandt Veerle , Günther Pomorski Thomas , Agostinis Patrizia , Wuytack Frank , Palmgren Michael , Eggermont Jan , Vangheluwe Peter 
Published: July 2015

Significance
ATP13A2 is a lysosomal transporter that is genetically linked to an autosomal recessive variant of Parkinson’s disease and confers protection against α-synuclein toxicity in neurons. Here we show that an N-terminal hydrophobic domain of ATP13A2 specifically recognizes signaling lipids. Interactions with these signaling lipids enhance cytoprotection to mitochondrial stress. This study provides essential information for establishing the lysosomal function of ATP13A2 and suggests a therapeutic applicability in activating ATP13A2.
Kolmogorov complexity in the Milky Way and its reduction with warm dark matter
Authors: Neyrinck Mark C. 
Published: July 2015

Abstract
We discuss the Kolmogorov complexity of primordial patches that collapse to form galaxies like the Milky Way; this complexity quantifies the amount of initial data available to form the structure. We also speculate on how the quantity changes with time. Because of dark-matter and baryonic collapse processes, it likely decreases with time, i.e. information sinks dominate sources. But sources of new random information do exist; e.g. a central black hole with an accretion disc and jets could in principle broadcast small-scale quantum fluctuations over a substantial portion of a galaxy. A speculative example of how this concept might be useful is in differentiating between warm (WDM) and cold (CDM) dark matter. With WDM, the initial patch that formed the Milky Way would have had few features, making the present high degree of structure a curiosity. The primordial patch would have had only several billion independent information-carrying ‘pixels’ if the WDM particle had a mass of 1 keV. This number of ‘pixels’ is much less than even the number of stars in the Milky Way. If the dark matter is proven to be warm, the high degree of structure in the Milky Way could have arisen in two ways: (i) from a high sensitivity to initial conditions, like an intricate fractal arising from a relatively simple computer code; or (ii) from random information generated after the Galaxy formed, i.e. not entirely deterministically from the initial conditions.
Survival trends of grade I, II, and III astrocytoma patients and associated clinical practice patterns between 1999 and 2010: A SEER-based analysis
Authors: Dong Xuezhi , Noorbakhsh Abraham , Hirshman Brian R. , Zhou Tianzan , Tang Jessica A. , Chang David C. , Carter Bob S. , Chen Clark C. 
Published: July 2015

Abstract

Background
The survival trends and the patterns of clinical practice pertaining to radiation therapy and surgical resection for WHO grade I, II, and III astrocytoma patients remain poorly characterized.

Methods
Using the Surveillance, Epidemiology and End Results (SEER) database, we identified 2497 grade I, 4113 grade II, and 2755 grade III astrocytomas during the period of 1999–2010. Time-trend analyses were performed for overall survival, radiation treatment (RT), and the extent of surgical resection (EOR).

Results
While overall survival of grade I astrocytoma patients remained unchanged during the study period, we observed improved overall survival for grade II and III astrocytoma patients (Tarone-Ware P < .05). The median survival increased from 44 to 57 months and from 15 to 24 months for grade II and III astrocytoma patients, respectively. The differences in survival remained significant after adjusting for pertinent variables including age, ethnicity, marital status, sex, tumor size, tumor location, EOR, and RT status. The pattern of clinical practice in terms of EOR for grade II and III astrocytoma patients did not change significantly during this study period. However, there was decreased RT utilization as treatment for grade II astrocytoma patients after 2005.

Conclusion
Results from the SEER database indicate that there were improvements in the overall survival of grade II and III astrocytoma patients over the past decade. Analysis of the clinical practice patterns identified potential opportunities for impacting the clinical course of these patients.
Genitourinary Procedures as Risk Factors for Prosthetic Hip or Knee Infection: A Hospital-Based Prospective Case-Control Study
Authors: Gupta Arjun , Osmon Douglas R. , Hanssen Arlen D. , Lightner Deborah J. , Wilson Walter R. , Steckelberg James M. , Baddour Larry M. , Harmsen William S. , Mandrekar Jay N. , Berbari Elie F. 
Published: July 2015

Abstract
Background.  The purpose of this study was to determine the risk of prosthetic joint infection (PJI) as a complication of routine genitourinary (GU) procedures in patients with total hip arthroplasty (THA) or total knee arthroplasty (TKA) and to study the impact of antibiotic prophylaxis administered prior to these procedures.
Methods.  We conducted a prospective, single-center, case-control study between December 1, 2001 and May 31, 2006. Case patients were hospitalized with total hip or knee PJI. Control subjects underwent a THA or TKA and were hospitalized during the same period on the same orthopedic floor without a PJI. Data regarding demographic features and potential risk factors were collected. The outcome measure was the odds ratio (OR) of PJI after GU procedures performed within 2 years of admission.
Results.  A total of 339 case patients and 339 control subjects were enrolled in the study. Of these, 52 cases (15%) and 55 controls (16%) had undergone a GU procedure in the preceding 2 years. There was no increased risk of PJI for patients undergoing a GU procedure with or without antibiotic prophylaxis (adjusted OR [aOR] = 1.0, 95% confidence interval [CI] = 0.2–4.5, P = .95 and aOR = 1.0, 95% CI = 0.6–1.7, P = .99, respectively). Results were similar in a subset of patients with a joint age less than 6 months, less than 1 year, or greater than 1 year.
Conclusions.  Genitourinary procedures were not risk factors for subsequent PJI. The use of antibiotic prophylaxis before GU procedures did not decrease the risk of subsequent PJI in our study.
Low Vitamin D Levels are Associated With Need for Surgical Correction of Pediatric Fractures
Authors: Minkowitz Barbara , Cerame Barbara , Poletick Eileen , Nguyen Joseph T. , Formoso Nicole D. , Luxenberg Sherri L. , Lee Ben H. , Lane Joseph M. 
Published: July 2015

Background:
There is growing concern over the relationship between the severity of pediatric fractures and low vitamin D [25-hydroxyvitaminD (25(OH)D)] status.

Objective:
Compare 25(OH)D levels and lifestyle of children with fractures to nonfracture controls to determine if 25(OH)D levels are associated with fractures and if there is a 25(OH)D fragility fracture threshold.

Methods:
Pediatric fracture and nonfracture controls were included. Bone health survey and medical record data were analyzed. Fractures were categorized using the Abbreviated Injury Scale (AIS). AIS 3 fractures were identified as fractures that required surgical intervention. Univariate and multivariable ordinal regression analyses were performed to identify potential risk factors for increased fracture severity.

Results:
A total of 369 fracture patients and 662 nonfracture controls aged 18 years and younger were included. Both groups’ 25(OH)D levels were comparable. 25(OH)D was 27.5±8.9 in the fracture group compared with 27.4±9.1 ng/mL in nonfracture controls (P=0.914). AIS 3 fractures had lower 25(OH)D levels (24.6±9.3 ng/mL) versus AIS 1 and 2 (30.0±10.8 and 28.3±8.4, respectively, P=0.001). Univariate correlations for AIS severity were found with age (P=0.015) and outdoor playtime (P=0.042). Adjusted odds ratios for 25(OH)D levels <12 ng/mL was 55.4 (P=0.037), 25(OH)D between 12 and 20 ng/mL was 6.7 (P=0.039), 25(OH)D between 20 and 30 ng/mL was 2.8 (P=0.208), and 25(OH)D between 30 and 40 was 1.7 (P=0.518).

Clinical Relevance:
Occurrence of a pediatric fracture was not associated with 25(OH)D levels in our study. However, children with lower vitamin D levels were found to be at higher risk for more severe fractures. Early evidence suggests that the target serum level for 25(OH)D should be at least 40 ng/mL in patients less than 18 years of age as the relative risk of more severe fractures increased as 25(OH)D levels decreased <40 ng/mL.

Level of Evidence:
Level III.
Evaluating hotels rating prediction based on sentiment analysis services
Authors: López Barbosa Rutilio Rodolfo , Sánchez-Alonso Salvador , Sicilia-Urban Miguel Angel 
Published: July 2015

Purpose– The purpose of this paper is to assess the reliability of numerical ratings of hotels calculated by three sentiment analysis algorithms.Design/methodology/approach– More than one million reviews and numerical ratings of hotels in seven cities in four countries were extracted from TripAdvisor web site. Reviews were classified as positive or negative using three sentiment analysis tools. The percentage of positive reviews was used to predict numerical ratings that were then compared with actual ratings.Findings– All tools classified reviews as positive or negative in a way that correlated positively with numerical ratings. More complex algorithms worked better, yet predicted ratings showed reasonable agreement with actual ratings for most cities. Predictions for hotels were less reliable if based on less than 50-60 percent of available reviews.Practical implications– These results validate that sentiment analysis can be used to transform unstructured qualitative data on user opinion into quantitative ratings. Current tools may be useful for summarizing opinions of user reviews of products and services on web sites that do not require users to post numerical ratings such as traveler forums. This summarizing may be valuable not just to potential users, but also to the service and product providers and offers validation and benchmarking for future improvement of opinion mining and prediction techniques.Originality/value– This work assesses the correlation between sentiment analysis of hotels’ reviews and their actual ratings. The authors also evaluated the reliability of results of sentiment analysis calculated by three different algorithms.
Miniaturized stacked implant antenna design at ISM band with biocompatible characteristics
Authors: Kaka Ademola O. , Toycan Mehmet , Walker Stuart D. 
Published: July 2015

Purpose
– A vertically stacked, three layer hybrid Hilbert fractal geometry and serpentine radiator-based patch antenna is proposed and characterized for medical implant applications at the Industrial, Scientific and Medical band (2.4-2.48 GHz). Antenna parameters are optimised to achieve miniaturized, biocompatible and stable transmission characteristics. The paper aims to discuss these issues.

Design/methodology/approach
– Human tissue effects on the antenna electrical characteristics were simulated with a three-layer (skin, fat and muscle) human tissue model with the dimensions of 180×70×60 mm3 (width×height×thickness mm3). Different stacked substrates are utilized for the satisfactory characteristics. Two identical radiating patches are printed on Roger 3,010 (ε
r=10.2) and Alumina (ε
r=9.4) substrate materials, respectively. In addition, various superstrate materials are considered and simulated to prevent short circuit the antenna while having a direct contact with the metallization, and achieve biocompatibility. Finally, superstrate material of Zirconia (ε
r=29) is used to achieve biocompatibility and long-life. A finite element method is used to simulate the proposed hybrid model with commercially available Ansoft HFSS software.

Findings
– The antenna is miniaturized, having dimensions of 10×8.4×2 mm3 (width×height×thickness mm3). The resonance frequency of the antenna is 2.4 GHz with a bandwidth of 100 MHz at return loss (S11) of better than −10 dB characteristics. Overall, the proposed antenna have 50 Ω impedance matching, −21 dB far field antenna gain, single-plane omni-directional radiation pattern properties and incident power of 5.3 mW to adhere Specific Absorption Rate regulation limit.

Originality/value
– Vertically stacked three layer hybrid design have miniaturized characteristics, wide bandwidth, biocompatible, and stable characteristics in three layer human tissue model make this antenna suitable for implant biomedical monitor systems. The advanced simulation analysis of the proposed design constitutes the main contribution of the paper.
Design and implementation of maximum constant boost switched inductor z-source inverter for three-phase on-line uninterrupted power supply
Authors: Chitra K. , Jeevanandham A. 
Published: July 2015

Purpose
– The purpose of this paper is to present the Switched Inductor Z-Source Inverter (SLZSI) topology for three-phase on-line uninterruptible power supply (UPS) by employing third harmonic injected maximum constant boost pulse width modulation (PWM) control. Conventional UPS consists of step-up transformer or boost chopper along with voltage source inverter (VSI) which reduces the efficiency and increases energy conversion cost. The proposed three-phase UPS by using SLZSI has the voltage boost capability through shoot through zero state which is not available in traditional VSI and current source inverter.

Design/methodology/approach
– Performance of three-phase on-line UPS based on ZLZSI by using third harmonic injected maximum constant boost PWM control is analyzed and evaluated in MATLAB/Simulink software and the results are compared with Z-source inverter (ZSI) fed UPS. Experimental results are presented for the validation of the simulation and theoretical analysis.

Findings
– The output voltages, currents, THD values, voltage stress and efficiencies for different loading condition are determined and compared with the theoretical values and UPS with ZSI. The experimental results validate the theoretical and simulation results.

Originality/value
– Compared with the traditional ZSI, the SLZSI provides high-voltage boost inversion ability with a very short shoot through zero state. This proposed UPS by using SLZSI increases the efficiency with less number of components, reduces the harmonics, increases the voltage gain and reduces the voltage stress.
Analysis of finite frequency selective surfaces backed by dielectric substrate using sub-entire-domain basis function method
Authors: Wang Quan-Quan , Zhu Hong-Bo , Chen Ru-Shan , Hu Yun-Qin 
Published: July 2015

Purpose
– Analysis of the frequency selective surface (FSS) is of great significance. In the method of moments, when the electric size of the FSS increases, huge in-core memory and CPU time are required. The purpose of this paper is to efficiently analyze the finite FSS backed by dielectric substrate utilizing sub-entire-domain (SED) basis function method.

Design/methodology/approach
– Different types of SED basis functions are generated according to the locations of the cells in the entire structure, and a reduced system is constructed and solved. The couplings of all cells of the FSS are taken into account by using Green’s function and Galerkin’s test procedure. The spatial Green’s function is obtained with the discrete complex image method. The reflection and transmission coefficients of the FSS are calculated using the far field of the FSS and the metallic plate with the same size.

Findings
– Moderate problems of the finite FSS backed by dielectric substrate are solved with the SED basis function method. The original problem can be simplified to two smaller problems. It enables a significant reduction to the matrix size and storage, and efficient analysis of FSS can be performed. The band-stop type of FSS can be composed of periodic conductive patch cells on the dielectric substrate, and shows total reflection property at the resonant frequency.

Originality/value
– The SED basis function method is mostly used to analyze periodic PEC structures in free space. The layered medium Green’s function is successfully employed and several dielectric substrate backed finite FSSs are discussed in this paper. The calculation of reflection and transmission coefficients, which are more effective rather than far field scattering of the FSS, are described.
Response of personal exposimeters for exposure assessment in the GSM900 downlink band
Authors: Thielens Arno , Agneessens Sam , Vermeeren Günter , Verloock Leen , Rogier Hendrik , Martens Luc , Joseph Wout 
Published: July 2015

Purpose
– The purpose of this paper is to numerically determine the distribution of electric fields registered by a personal exposimeter (PEM) used for the Global System for Mobile Communications (GSM) around 900 MHz (GSM900) downlink (DL) band and compare these with calibration measurements of PEMs worn by real human subjects.

Design/methodology/approach
– Numerical simulations using the Virtual Family Male (VFM) are carried out at 950 MHz in order to determine the electric fields surrounding the phantom in realistic, far-field environments. These electric fields can be used to determine the distribution of a PEM’s response when worn by the VFM. Simultaneously, calibration measurements in an anechoic chamber are carried out using a real PEM worn by two different subjects, in order to determine the PEM’s response experimentally.

Findings
– Both the numerical simulations and the measurements show that a PEM will on average underestimate the incident electric fields in the GSM900 DL band and that the variation (expressed in terms of the 95 percent confidence interval and the interquartile distance) on its response is relatively large: a 95 percent confidence interval of 22 dB and an interquartile distance of 7.3 dB are found in a realistic environment using numerical simulations, while the calibration measurements show interquartile distances up to 12 dB. In terms of variation there is an excellent agreement between simulations and measurements.

Originality/value
– This paper proves that numerical simulations may be used as a replacement for the more time- and work-consuming calibration measurements if the variation of a PEM’s response is studied.
Using multiple exposimeters to evaluate the influence of the body when measuring personal exposition to radio frequency electromagnetic fields
Authors: Nájera López Alberto , Gonzalez-Rubio Jesus , Villalba Montoya José Manuel , Arribas Garde Enrique 
Published: July 2015

Purpose
– Since first small personal exposimeters became available, some studies have characterized personal exposition to radio frequency electromagnetic fields. The effect of body and relative position of the exposimeter have been also analyzed but some questions are still unanswered. The paper aims to discuss these issues.

Design/methodology/approach
– Using three personal exposimeters in four different subjects, the authors characterized and compared measurements in a controlled experiment.

Findings
– The authors found statistically significance differences between exposimeters and subjects due to relative position (right and left) and a control position far from the body (center). It should indicate that body and relative position of the exposimeter affect directly to the measurement, conditioning final and average results.

Research limitations/implications
– Measurements using personal exposimeters have to be reconsidered and controlled.

Originality/value
– The authors test personal exposimeters limitations in real conditions.
Reactance components embedded in printed circuit boards
Authors: Stęplewski Wojciech , Dziedzic Andrzej , Kłossowicz Adam , Winiarski Paweł , Borecki Janusz , Kozioł Grażyna , Serzysko Tomasz 
Published: July 2015

Purpose
– This paper aims to report the investigations of capacitors and inductors embedded into printed circuit boards (PCBs) designed in various layouts.

Design/methodology/approach
– The research were focused on the components embedded into four-layer PCBs with different structures of the inner layers. Three special capacitive laminates for manufacturing of thin-film embedded capacitors and several types of coils in the form of a spiral, meander and solenoid are described. In addition, a part of the spiral-type coils was formed with an aperture in the center in which the magnetic core, made of soft magnetic composites’ material was placed to increase the coil inductance.

Findings
– Various constructions of embedded capacitors and coils were designed and manufactured. Capacitance and loss tangent of capacitors to determine the repeatability of the production process were determined. Capacitor’s long-term stability analysis was performed by exposing test samples to elevated temperatures (70, 100 or 130°C), realized with the aid of heating plate, for at least 160 h. The temperature characteristics for the capacitance and loss tangent from 15 to 100°C were determined. Also the induction of different designs and layouts coils was determined.

Originality/value
– The wide parameters’ characterization of capacitors and coils embedded into PCBs allow the analysis of their properties with regard to their practical application. The promising results of the realized measurements show that the capacitors and induction coils with studied structures can be widely used in the construction of embedded circuits into PCBs (e.g. filters, radio frequency identification systems and generators).