bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allied rehabilitation using caregiver-mediated exercises combined with telerehabilitation for stroke (ARMed4Stroke): A randomised controlled trial
Authors: Mulder Marijn , Nikamp Corien DM , Prinsen Erik C , Nijland Rinske HM , van Dorp Matthijs , Buurke Jaap , Kwakkel Gert , van Wegen Erwin EH 
Published: August 2024

Objective To assess the added value of caregiver-mediated exercises combined with telerehabilitation in addition to usual care compared to usual care alone on the self-reported mobility outcome after subacute stroke. Design Multicentre, observer-blinded, parallel randomised controlled trial. An off-site researcher allocated treatments using minimisation. Setting Four rehabilitation centres in the Netherlands. Participants Forty-one patient–caregiver dyads within 3 months poststroke. Intervention Eight-week blended care program with caregiver-mediated mobility exercises for 2.5 h per week supported by telerehabilitation and four face-to-face sessions in addition to usual care. Main measures Self-reported mobility domain of the Stroke Impact Scale postintervention. Secondary outcomes were functional outcome, dyads’ psychosocial wellbeing, care transition to the community postintervention and after 6 months. Results Forty-one dyads (21 intervention, 20 control) were randomised, and 37 (N = 18; N = 19) were analysed following intention-to-treat. The Stroke Impact Scale mobility was not significantly different between groups postintervention (B 0.8, 95% CI –6.8–8.5, p = 0.826). The secondary outcomes, namely, (a) caregivers’ quality of life postintervention ( p = 0.013), (b) caregivers’ symptoms of depression postintervention ( p = 0.025), and (c) independence in leisurely activities at 6 months ( p = 0.024), showed significant benefits in favour of caregiver-mediated exercises with telerehabilitation. A significant difference favouring controls was found in self-reported muscle strength at 6 months ( p = 0.002). Conclusions Caregiver-mediated exercises combined with telerehabilitation yielded no differential effect on our primary outcome self-reported mobility. Although the trial is underpowered, current findings are in line with previous trials. Future studies should further explore beneficial effects of caregiver involvement in stroke rehabilitation targeting psychosocial wellbeing.
Oculomotor Behaviour in Individuals with Long COVID-19
Authors: González-Vides L , Hernández-Verdejo JL , Gómez-Pedrero JA , Ruiz-Pomeda A , Cañadas-Suárez P 
Published: August 2024

Objective To determine, the impact of long COVID-19 on oculomotor behaviour. Design A case–control study. Setting Spanish Association of Persistent COVID. Participant Participants were 75 cases (64 women, 11 men, mean age 46.4 years ±8.9) and 42 controls (22 women, 20 men, mean age 53.5 years ±13.13). Intervention An eye-tracking test based on visual search paradigm and the Adult Developmental Eye Movement Test were used to evaluate the participants. Main measures The primary outcomes in the Adult Developmental Eye Movement Test were horizontal reading time, vertical reading time, and their ratio. And for the eye-tracking test the time to find the target, the duration, and the number of eye fixations. Results In cases and controls, eye movement test results were horizontal(Hadj) reading time 74.2 ± 22.7 s vs 52.0 ± 6.1 s ( p < .0001); vertical(Vadj) reading time 67.6 ± 17.8 s vs 50.4 ± 6.9 s ( p < .0001); Hadj/Vadj ratio 0.9 ± 0.1 vs 1.0 ± 0 ( p = .0032), respectively; and eye-tracking test results were fixation number 11.3 ± 3.07 vs 3.51 ± 2.57 ( p < .0001); fixation duration 2.01 ± 0.79 s vs 1.5 ± 0.4 s ( p = .0013), and time to find target 24.5 ± 8.0 vs 18 ± 9.4 ( p = .0034), respectively. Conclusions Data showed a lower performance in oculomotor behaviour in people with long COVID-19, compared to healthy individuals. It cannot be affirmed an ocular musculature dysfunction; the differentiated behaviour could be associated to cognitive alterations affected in these people. Both tests used could be an useful tool for the clinical assessment of these participants. Further studies are needed to explore the utility of these procedures.
Impact of Structural Differences on the Modeled Cost-Effectiveness of Noninvasive Prenatal Testing
Authors: Salisbury Amber , Pearce Alison , Howard Kirsten , Norris Sarah 
Published: August 2024

Background Noninvasive prenatal testing (NIPT) was developed to improve the accuracy of prenatal screening to detect chromosomal abnormalities. Published economic analyses have yielded different incremental cost-effective ratios (ICERs), leading to conclusions of NIPT being dominant, cost-effective, and cost-ineffective. These analyses have used different model structures, and the extent to which these structural variations have contributed to differences in ICERs is unclear. Aim To assess the impact of different model structures on the cost-effectiveness of NIPT for the detection of trisomy 21 (T21; Down syndrome). Methods A systematic review identified economic models comparing NIPT to conventional screening. The key variations in identified model structures were the number of health states and modeling approach. New models with different structures were developed in TreeAge and populated with consistent parameters to enable a comparison of the impact of selected structural variations on results. Results The review identified 34 economic models. Based on these findings, demonstration models were developed: 1) a decision tree with 3 health states, 2) a decision tree with 5 health states, 3) a microsimulation with 3 health states, and 4) a microsimulation with 5 health states. The base-case ICER from each model was 1) USD$34,474 (2023)/quality-adjusted life-year (QALY), 2) USD$14,990 (2023)/QALY, (3) USD$54,983 (2023)/QALY, and (4) NIPT was dominated. Conclusion Model-structuring choices can have a large impact on the ICER and conclusions regarding cost-effectiveness, which may inadvertently affect policy decisions to support or not support funding for NIPT. The use of reference models could improve international consistency in health policy decision making for prenatal screening. Highlights NIPT is a clinical area in which a variety of modeling approaches have been published, with wide variation in reported cost-effectiveness. This study shows that when broader contextual factors are held constant, varying the model structure yields results that range from NIPT being less effective and more expensive than conventional screening (i.e., NIPT was dominated) through to NIPT being more effective and more expensive than conventional screening with an ICER of USD$54,983 (2023)/QALY. Model-structuring choices may inadvertently affect policy decisions to support or not support funding of NIPT. Reference models could improve international consistency in health policy decision making for prenatal screening.
Enhanced audiovisual associative pair learning in migraine without aura in adult patients: An unexpected finding
Authors: Tót Kálmán , Braunitzer Gábor , Harcsa-Pintér Noémi , Kiss Ádám , Bodosi Balázs , Tajti János , Csáti Anett , Eördegh Gabriella , Nagy Attila 
Published: August 2024

Background Altered sensory processing in migraine has been demonstrated by several studies in unimodal, and especially visual, tasks. While there is some limited evidence hinting at potential alterations in multisensory processing among migraine sufferers, this aspect remains relatively unexplored. This study investigated the interictal cognitive performance of migraine patients without aura compared to matched controls, focusing on associative learning, recall, and transfer abilities through the Sound-Face Test, an audiovisual test based on the principles of the Rutgers Acquired Equivalence Test. Materials and Methods The performance of 42 volunteering migraine patients was compared to the data of 42 matched controls, selected from a database of healthy volunteers who had taken the test earlier. The study aimed to compare the groups’ performance in learning, recall, and the ability to transfer learned associations. Results Migraine patients demonstrated significantly superior associative learning as compared to controls, requiring fewer trials, and making fewer errors during the acquisition phase. However, no significant differences were observed in retrieval error ratios, generalization error ratios, or reaction times between migraine patients and controls in later stages of the test. Conclusion The results of our study support those of previous investigations, which concluded that multisensory processing exhibits a unique pattern in migraine. The specific finding that associative audiovisual pair learning is more effective in adult migraine patients than in matched controls is unexpected. If the phenomenon is not an artifact, it may be assumed to be a combined result of the hypersensitivity present in migraine and the sensory threshold-lowering effect of multisensory integration.
La Base de données sur les innovations sociales du CRISES : portée et limites d’une innovation méthodologique
Authors: Longtin David , Bouchard Marie J. , Michaud Valérie , Rousselière Damien 
Published: August 2024

Résumé Depuis les années 1990, l’étude des innovations sociales fait l’objet de débats entourant les problèmes de recherche, les approches théoriques et les méthodes. La majorité des recherches ont privilégié les études de cas. Toutefois, plus récemment, des chercheurs ont commencé à réaliser des méta-études à partir de banques de données qualitatives. Cet article examine une démarche novatrice mise en œuvre par le Centre de recherche sur les innovations sociales (CRISES). Partant de centaines d’étude de cas, le CRISES a mis sur pied une base de données sur l’innovation sociale en vue de réaliser des analyses statistiques. Après avoir présenté les tendances en sciences sociales à la constitution de banques de données et à la réalisation de méta-études, nous exposons la méthodologie et les assises épistémologiques du projet afin d’en dégager l’originalité au regard des cartographies d’innovations sociales. L’article se conclut par une évaluation des limites méthodologiques et de la portée analytique du projet.
Kinetics of Renin Concentrations in Infants Undergoing Congenital Cardiac Surgery
Authors: Kim Michael E. , Gist Katja M. , Brandewie Katie , Zang Huaiyu , Lehenbauer David , Winlaw David S. , Morales David L.S. , Alten Jeffrey A. , Goldstein Stuart L. , Cooper David S. 
Published: August 2024

Background Elevated renin has been shown to predict poor response to standard vasoactive therapies and is associated with poor outcomes in adults. Similarly, elevated renin was associated with mortality in children with septic shock. Renin concentration profiles after pediatric cardiac surgery are unknown. The purpose of this study was to characterize renin kinetics after pediatric cardiac surgery. Methods Single-center retrospective study of infants who underwent cardiac surgery with cardiopulmonary bypass (CPB) utilizing serum samples obtained in the perioperative period to measure plasma renin concentrations (pg/mL). Time points included pre-bypass and 1, 4, and 24 h after initiation of CPB. Results Fifty patients (65% male) with a median age 5 months (interquartile range (IQR) 3.5, 6.5) were included. Renin concentrations peaked 4 h after CPB. There was a significant difference in preoperative and 4 h post-CPB renin concentration (4 h post-CPB vs preoperative: mean difference 100.6, 95% confidence interval (CI) 48.9-152.4, P < .001). Median renin concentration at 24 h after CPB was lower than the preoperative baseline. Conclusions We describe renin kinetics in infants after CPB. Future studies based on these data can now be performed to evaluate the associations of elevated renin concentrations with adverse outcomes.
Enhancing the mechanical and electrical properties of irradiated acrylonitrile butadiene rubber/magnetite nanocomposites for electromagnetic shielding applications
Authors: Mounir Rania , El Zayat MM , Sharaf A , El-Gamal AA 
Published: August 2024

By using a traditional roll mill, nitrile butadiene rubber (NBR)/magnetite nanocomposites for electromagnetic interference shielding applications were successfully prepared. The synthesized magnetite nanoparticles were analyzed using X-ray diffraction (XRD), Fourier transform infrared (FTIR), transmission electron microscope (TEM), and energy dispersive X-ray (EDX) techniques. The results from these techniques emphasis the preparation of Fe3O4 with a diameter range between 3.8 nm and 19 nm. Before and after gamma irradiation at different doses the impact of adding different contents of magnetite nanoparticles in NBR was carefully examined through mechanical and electrical measurements for all samples at room temperature. The mechanical parameters and the electrical properties of NBR were enhanced after adding Fe3O4 nanoparticles. Electromagnetic interference shielding (EMI) for all fabricated nanocomposites before and after gamma-ray irradiation under the same conditions of pressure, humidity and temperature was performed as a promising application for these materials in practical life. The electromagnetic shielding effectiveness (SE) of the prepared samples was measured in the X-band of the radio frequency range. There are three global maxima around 9.4 GHz, 10.4 GHz, and 11.4 GHz. Subsequent reinforcement of Fe3O4 nanoparticles into NBR produced higher shielding effectiveness for radio frequency signals. Furthermore, applied gamma radiation doses improved the shielding properties of the fabricated nanocomposites.
Comparison of clinical and serological features in thrombotic antiphospholipid syndrome patients, with and without associated systemic lupus erythematosus, followed for up to 42 years: A single centre retrospective study
Authors: Mittal Prabal , Pacheco Marina , Trives-Folguera Laura , Rua Joana , Tohidi-Esfahani Ibrahim , Cohen Hannah , Efthymiou Maria , Isenberg David 
Published: August 2024

Objective To assess the impact of concomitant systemic lupus erythematosus (SLE) on the clinicopathological manifestations of thrombotic antiphospholipid syndrome (APS). Methods This single-centre, retrospective study compared clinical and antiphospholipid antibody (aPL) data from 118 patients, 58 with SLE-associated APS (SLE-APS), and 60 with primary APS. Results Median follow-up was 13.9 (IQR 7.7–19.3) and 8.6 years (3.5–10.6) for the SLE-APS cohort and PAPS cohort, respectively. Age at diagnosis of APS was lower in the SLE-APS cohort (mean 35.9 vs PAPS: 46.7 years; p < 0.05). Distribution of aPL subtypes was similar across cohorts. 198 thrombotic events were identified overall (index plus recurrent), with venous thromboembolism (VTE) and arterial thrombosis each occurring in just over half of patients in both cohorts. Microvascular thrombosis (12.1% vs 0%), and a mixed (any combination of venous, arterial and microvascular) thrombotic phenotype (19.0% vs 6.7%, p = 0.05) were more prevalent in SLE-APS patients. Recurrent thrombosis incidence rates (∼0.5 events/10-patient years), and Kaplan-Meier recurrence-free survival after index thrombosis, were similar. In the PAPS cohort, only: (i) triple-aPL-positivity was associated with a significantly higher recurrent thrombosis event rate (incidence rate ratio 2.22, p = 0.03) and lower recurrence-free survival after first thrombosis (log-rank test p = 0.01); (ii) lupus anticoagulant (LA)-positivity was associated with higher prevalance of arterial thrombosis (RR 2.69, p = 0.01), and lower prevlance of VTE (RR 0.48, p < 0.001), versus LA-negativity. Conclusion Concomitant SLE does not appear to modify long-term recurrent thrombosis risk, or aPL phenotypes, in patients with APS. Triple-aPL-positivity and LA-positive status may have less influence on thrombotic outcomes in patients with SLE-APS compared to PAPS.
Visual Entrainment Improving Working Memory of Children With and Without ADHD/ASD: Preliminary Observations
Authors: Basu Sandhya , Phogat Richa , Banerjee Bidisha , Parmananda Punit 
Published: August 2024

Background: Children, especially those with neurodevelopmental disorders, often experience challenges in memory functioning. This literature directs to the imperative implications of working memory (WM), especially in academics. Objective: Given the distinct nature of WM in children and those with neurodevelopmental disorders, our study explored the role of alpha and beta visual entrainment on their WM performances. Methods: NCPs ( n = 19) and CPs with ADHD and comorbid conditions of autism ( n = 15) participated in our study. We adopted a repeated measure intervention-based design along with alpha-and-beta visual entrainment. Pretest, posttest, and follow-up data were collected using digit span tests. Electroencephalography (EEG) was further recorded during the entrainment phase. We administered statistical and coherence factor analysis to derive our results. Results: We observed that experimental participants performed better following the visual entrainment sessions. We further observed that alpha entrainment affected the digit span scores among clinical participants, whereas beta entrainment affected the performance of the nonclinical group. The entrainment effects additionally varied depending on the participant’s clinical symptoms. However, we found negligible long-term entrainment effects on their WM. Conclusion: Our observations explore the probability of individual effects of alpha and beta entrainment sessions on children’s WM performances and open an avenue for further research in the clinical domain. The study suggests translating brainwave entrainment into an intervention to promote cognition among children, especially those with neurodevelopmental disorders.
Biomechanical and histological evaluation of aspirin in rotator cuff tear rat model
Authors: Chung Seok Won , Chung Seung Ho , Kim Dong-Hyun , Lee Hyun Joo , Park Eugene J , Shim Bum-Jin , Cho Chul-Hyun , Yoon Jong Pil 
Published: August 2024

Background: Aspirin is a representative non-steroidal anti-inflammatory drug (NSAIDs) and has been commonly used for the treatment of tendinopathy in clinical practice. In this study, we aimed to evaluate the biomechanical and histological healing effects of aspirin on the healing of the tendon-to-bone interface after rotator cuff tear repair. Methods: A total of 20 male Sprague-Dawley rats were randomly divided into two groups of 10 rats each. Group-C performed repaironly, and group-aspirin treated with aspirin after tendon repair. Group-aspirin rat were intraperitoneally injected with aspirin at 10 mg/kg every 24 h for 7 days. Eight weeks after surgery, the left shoulder of each rat was used for histological analysis and the right shoulder for biomechanical analysis. Results: In the biomechanical analysis, there was no significant difference in load-to-failure (group-C: 0.61 ± 0.32 N, group-aspirin: 0.74 ± 0.91 N; p = .697) and ultimate stress (group-C: 0.05 ± 0.01 MPa, group-aspirin: 0.29 ± 0.43 MPa; p = .095). For the elongation (group-C: 222.62 ± 57.98%, group-aspirin: 194.75 ± 75.16%; p = .028), group-aspirin confirmed a lower elongation level than group-C. In the histological evaluation, the Bonar score confirmed significant differences in collagen fiber density (group-C: 1.60 ± 0.52, group-aspirin: 2.60 ± 0.52, p = .001) and vascularity (group-C: 1.00 ± 0.47, group-aspirin: 2.20 ± 0.63, p = .001) between the groups. Conclusions: Aspirin injection after rotator cuff tear repair may enhance the healing effect during the early remodeling phase of tendon healing.
Using Social Media Data to Understand Citizen Perceptions of Urban Planning in a City Simulation Game
Authors: Qiu Yujia , Lin Yanliu , He Junyao , Lu Hongmei 
Published: August 2024

Background City simulation games provide players a gaming experience by simulating different aspects of the real city. While there is an increasing scholarly interest in games for social learning and education, little research has been conducted to understand citizen perceptions and understanding of urban planning issues in city simulation games. Aim This study aims to understand the affective perception and cognitive learning of citizens regarding urban planning elements in the online communities of Cities: Skylines. Research Methods We develop a new methodological approach based on social media data analytics. Large datasets were scraped from Reddit, the most popular social media platform for video game players. The collected data were subjected to content analysis and sentiment analysis that identify different types of topics and emotions to understand citizens’ cognitive and affective perspectives. Key Findings and Conclusion The findings show that positive emotions were often about the game design, while negative emotions conveyed real-world planning problems such as transportation concerns. The cognitive dimension uncovered citizens’ urban recognition tied to personal experiences in various geographical contexts. This study has practical implications for game design for urban planning.
Roles of Chaplains and Clergy in Spiritual Care for African Americans in Hospice: A Pilot Study
Authors: Quigley Denise D. , McCleskey Sara G. , Lesandrini Jason , McNeal Natalie , Qureshi Nabeel 
Published: August 2024

Context Spiritual care is recognition of patient and caregiver spiritual/religious needs and attention to those needs. Caregivers of African American hospice patients are more likely to report worse emotional/religious support. Yet, spiritual care delivery and roles of community clergy and chaplains for African American hospice patients are not well understood. Objectives Examine who provides spiritual care to African American hospice patients and caregivers. Methods Partnering with large, urban/suburban community hospice, we interviewed caregivers of deceased African American hospice patients (n = 12), their clergy (n = 3) and chaplains (n = 5). Using a phenomenological qualitative study design, we coded transcripts and deceased patient chart data and conducted thematic analysis to identify themes. Results Community clergy and chaplains tend to not interact and provide different aspects of emotional, religious and spiritual support to hospice patients and families. Clergy and chaplains agreed that rapport and openness of the patient were main factors in meeting spiritual care needs. Clergy provided interaction with a trusted person and connection to church, congregational support, religious beliefs/theology, and practices. Chaplains focused on present needs and issues of death and dying. Conclusion Clergy and chaplains have distinct, complementary roles in providing spiritual care to African American hospice patients and families. Both are needed to provide desired spiritual care for African American hospice patients and their caregivers. Robust spiritual care programs need to ensure chaplains have sufficient time to spend with patients and families and incorporate collaboration, handoffs and integrated processes for clergy and chaplains. Research is needed on effectively including clergy in hospice spiritual care delivery.