bluuebunny/crossref_metadata_2025_split huggingface dataset:
Campus Food and Beverage Purchases are Associated with Indicators of Diet Quality in College Students Living off Campus
Authors: Pelletier Jennifer E. , Laska Melissa N. 
Published: May 2013

Purpose. To examine the association between college students' dietary patterns and frequency of purchasing food/beverages from campus area venues, purchasing fast food, and bringing food from home. Design. Cross-sectional Student Health and Wellness Study. Setting. One community college and one public university in the Twin Cities, Minnesota. Subjects. Diverse college students living off campus (n = 1059; 59% nonwhite; mean [SD] age, 22 [5] years). Measures. Participants self-reported sociodemographic characteristics and frequency of purchasing food/beverages around campus, purchasing fast food, and bringing food from home. Campus area purchases included à la carte facilities, vending machines, beverages, and nearby restaurants/stores. Dietary outcomes included breakfast and evening meal consumption (d/wk) and summary variables of fruit and vegetable, dairy, calcium, fiber, added sugar, and fat intake calculated from food frequency screeners. Analysis. The associations between each purchasing behavior and dietary outcomes were examined using t-tests and linear regression. Results. Approximately 45% of students purchased food/beverages from at least one campus area venue ≥ 3 times per week. Frequent food/beverage purchasing around campus was associated with less frequent breakfast consumption and higher fat and added sugar intake, similar to fast-food purchasing. Bringing food from home was associated with healthier dietary patterns. Conclusion. Increasing the healthfulness of campus food environments and promoting healthy food and beverage purchasing around campuses may be an important target for nutrition promotion among college students.
Mobile teledermoscopy—there’s an app for that!
Authors: Börve Alexander , Terstappen Karin , Sandberg Carin , Paoli John 
Published: May 2013

Background: The introduction of the smartphone with high-quality, built-in digital cameras and easy-to-install software may make it more convenient to perform teledermatology. In this study we looked at the feasibility of using a smartphone (iPhone 4®) with an installed application especially developed for teledermatology (iDoc24®) and a dermoscope (FotoFinder Handyscope®) that is customized to attach to the smartphone to be able to carry out mobile teledermoscopy.
Objectives: To study the diagnostic accuracy of this mobile teledermoscopy solution, to determine the interobserver concordance between teledermoscopists (TDs) and a dermatologist meeting the patient face-to-face (FTF), and to assess the adequacy of the TDs’ management decisions and to evaluate the image quality obtained.
Patients/Methods: During a 16-week period, patients with one or more suspicious skin lesions deemed to need a biopsy or excision were included. The smartphone app was used to send a clinical image, a dermoscopy image and relevant clinical information to a secure Internet platform (Tele-Dermis®). Two TDs assessed the incoming cases, providing a specific primary diagnosis and a management decision. They also graded the image quality. The histopathological diagnosis was used as the gold standard.
Results: Sixty-nine lesions were included. The FTF dermatologist’s diagnostic accuracy was 66.7%, which was statistically higher than TD 1 (50.7%, P=0.04) but similar to TD 2 (60.9%, P=0.52). The interobserver concordances between the FTF dermatologist and the two TDs and between the respective TDs showed moderate to substantial agreement. The TDs provided adequate management decisions for 68 (98.6%) and 69 (100%) lesions, respectively. The image quality was rated as excellent or sufficient in 94% and 84% of the cases by the respective TDs.
Conclusion: This novel mobile teledermoscopy solution may be useful as a triage tool for patients referred to dermatologists for suspicious skin lesions.
Ene‐Carbonyl Reductive Coupling Mediated by Zinc and Ammonia for the Synthesis of γ‐Hydroxybutyric Acid Derivatives
Authors: Yeh Chien‐Hung , Korivi Rajendra Prasad , Cheng Chien‐Hong 
Published: May 2013

AbstractThe reductive coupling of an aryl carbonyl group with an activated alkene to give the corresponding γ‐hydroxybutyric acid (GHBA) derivative was achieved in the presence of zinc and ammonia. A board scope of GHBA derivatives could be synthesized under ambient conditions by this method. A mechanism involving a Zn‐ketyl radical as the key intermediate is proposed.
Rhodium‐Catalyzed Asymmetric Cycloisomerization of 1,6‐Ene‐ynamides
Authors: Nishimura Takahiro , Takiguchi Yuka , Maeda Yuko , Hayashi Tamio 
Published: May 2013

AbstractThe rhodium‐catalyzed asymmetric cycloisomerization of heteroatom‐bridged 1,6‐ene‐ynamides proceeded to give high yields of functionalized 3‐aza‐ and oxabicyclo[4.1.0]heptene derivatives with high enantioselectivity, which was achieved by use of a rhodium/chiral diene catalyst. The 1,6‐ene‐ynamides substituted with 2‐oxazolidinone and 2‐azetidinone moieties at the alkyne terminus were found to display high reactivity towards the rhodium/chiral diene catalyst, where the chelate coordination of the alkyne moiety and the carbonyl oxygen of the ene‐ynamides might be responsible for the high catalytic activity.
Enantioselective Synthesis of α‐Amino‐γ‐sulfonyl Phosphonates with a Tetrasubstituted Chiral α‐Carbon via Quinine‐Squaramide‐Catalyzed Michael Addition of Nitrophosphonates to Vinyl Sulfones
Authors: Bera Kalisankar , Namboothiri Irishi N. N. 
Published: May 2013

Abstractα‐Nitro‐γ‐sulfonyl phosphonates with a key tetrasubstituted chiral α‐carbon center have been synthesized for the first time in high yield and enantioselectivity through a quinine‐squaramide‐catalyzed conjugate addition of α‐nitro phosphonates to aryl vinyl sulfones. Representative examples presented here for the transformation of nitrosulfonyl phosphonates to aminosulfonyl phosphonates, alkylation at the α‐position of the sulfonyl group followed by desulfonation and scale‐up of the conjugate addition highlight the practical applications of the methodology.
Enhancing the stability of immobilized catalase on activated carbon with gelatin encapsulation
Authors: Wang Yulin , Guan Yuepeng , Yang Yin , Yu Peng , Huang Yaqin 
Published: May 2013

ABSTRACTGelatin (Gel) encapsulation onto activated carbon (AC) with catalase (CAT) was developed as an alternative method for CAT immobilization in this study. The immobilized CAT with AC encapsulated by Gel as the supporter accounted for 65.69% of the native enzyme activity. Furthermore, the properties of the immobilized CATs were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. Among free CAT and the two immobilized CATs, the immobilized CAT with AC encapsulated by Gel as the supporter showed the highest relative enzymatic activity and a high stability in a broad range of pH values and temperatures, and its residual activity was 80% after 15 uses, whereas the immobilized CAT with AC as the supporter was retained at a level of only 50% under the same conditions. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1498–1502, 2013
Outcome of older patients with acute myeloid leukemia
Authors: Thein Mya S. , Ershler William B. , Jemal Ahmedin , Yates Jerome W. , Baer Maria R. 
Published: May 2013

BACKGROUNDAcute myeloid leukemia (AML) is the common form of acute leukemia in adults, accounting for over 80% of all acute leukemias in individuals aged >18 years. Overall 5‐year survival remains poor in older AML patients; it is <5% in patients aged >65 years. In this study, the authors examined whether survival has improved for subsets of geriatric AML patients over 3 successive decades.METHODSSurveillance, Epidemiology and End Results (SEER) data were used to determine trends in relative survival by age among 19,000 patients with AML over 3 successive decades (1977‐1986, 1987‐1996, and 1997‐2006). Relative survival rates (RRs) with 95% confidence intervals (CIs) were calculated as measures of survival.RESULTSOverall, the RRs increased for each successive decade (1977‐1986, 1987‐1996, and 1997‐2006) in patients ages 65 to 74 years, with improvements in 12‐month survival from 20%, to 25%, to 30%, respectively. Findings were similar for 24‐month, 36‐month, 48‐month, and 60‐month survival. However, survival rates did not improve in patients aged ≥75 years. The oldest old patients (aged ≥85 years) had the lowest survival rates, with no apparent improvement.CONCLUSIONSThis analysis of a large data set demonstrated that, although overall survival remained unsatisfactory among older patients, it improved in the younger old (ages 65‐74 years). Survival of older old AML patients has not been favorably impacted by available AML therapies or supportive care, and intervention in this age group is best undertaken on a clinical trial. Cancer 2013;119:2720–2727. © 2013 American Cancer Society.
Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia
Authors: Kantarjian Hagop , Thomas Deborah , Jorgensen Jeffrey , Kebriaei Partow , Jabbour Elias , Rytting Michael , York Sergernne , Ravandi Farhad , Garris Rebecca , Kwari Monica , Faderl Stefan , Cortes Jorge , Champlin Richard , O'Brien Susan 
Published: May 2013

BACKGROUNDCD22 expression occurs in >90% of patients with acute lymphocytic leukemia (ALL). Inotuzumab ozogamicin, a CD22 monoclonal antibody bound to calicheamicin, is active in ALL.METHODSPatients with refractory‐relapsed ALL received treatment with inotuzumab. The first 49 patients received single‐dose, intravenous inotuzumab at doses of 1.3 to 1.8 mg/m2 every 3 to 4 weeks. In the next 41 patients, the schedule was modified to inotuzumab weekly at a dose of 0.8 mg/m2 on day 1 and at a dose of 0.5 mg/m2 on days 8 and 15, every 3 to 4 weeks, based on higher in vitro efficacy with more frequent exposure.RESULTSNinety patients were treated; 68% were in salvage 2 or beyond. Overall, 17 patients (19%) achieved a complete response (CR), 27 (30%) had a CR with no platelet recovery (CRp), and 8 (9%) had a bone marrow CR (no recovery of counts), for an overall response rate of 58%. Response rates were similar for single‐dose and weekly dose inotuzumab (57% vs 59%, respectively). The median survival was 6.2 months overall, 5.0 months with the single‐dose schedule, and 7.3 months with the weekly dose schedule. The median survival was 9.2 months for patients in salvage 1 (37% at 1 year), 4.3 months for patients in salvage 2, and 6.6 months for patients in salvage 3 or later. The median remission duration was 7 months. Reversible bilirubin elevation, fever, and hypotension were observed less frequently on the weekly dose. In total, 36 of 90 patients (40%) underwent allogeneic stem cell transplantation. Veno‐occlusive disease was noted in 6 of 36 patients after stem cell transplantation (17%), was less frequent after the weekly schedule (7%), and with less alkylators in the preparative regimen.CONCLUSIONSInotuzumab single‐agent therapy was highly active, safe, and convenient in patients with refractory‐relapsed ALL. A weekly dose schedule appeared to be equally effective and less toxic than a single‐dose schedule. Cancer 2013;119:2728–2736. © 2013 American Cancer Society.
Electronically controlled oscillator with linear frequency adjusting for four‐phase or differential quadrature output signal generation
Authors: Sotner Roman , Herencsar Norbert , Jerabek Jan , Koton Jaroslav , Dostal Tomas , Vrba Kamil 
Published: May 2013

ABSTRACTThis paper introduces novel four‐phase oscillator employing two Dual‐Output Controlled Gain Current Follower Buffered Amplifiers (DO‐CG‐CFBAs), single Current Amplifier, three resistors, and two grounded capacitors suitable for differential quadrature signal production (floating outputs). To control the frequency of oscillation (FO) and condition of oscillation (CO), only the current gain adjustment of active elements is used. The circuit was designed by well‐known state variable approach. The oscillator employs three active elements for linear control of FO and to adjust CO and provides low‐impedance voltage outputs. Furthermore, two straightforward ways of automatic amplitude gain control were used and compared. Active elements with very good performance are implemented to fulfill required features. Suitable CMOS implementation of introduced DO‐CG‐CFBA was shown. Important characteristics of the designed oscillator were verified experimentally and by PSpice simulations to confirm theoretical and expected presumptions. Copyright © 2013 John Wiley & Sons, Ltd.
On the non‐conjugacy of nightside aurora and their generator mechanisms
Authors: Reistad J. P. , Østgaard N. , Laundal K. M. , Oksavik K. 
Published: May 2013

AbstractWe have investigated a data set of 19 h of simultaneous global conjugate auroral imaging from space. The data set consists of 10 sequences with durations from 1 to 5 h during active geomagnetic conditions (average AE ∼ 400 nT). We have identified 15 features (including two presented earlier) of auroral forms that appear mainly in one hemisphere, and we define this as non‐conjugate aurora. Three generator mechanisms has been suggested for producing interhemispheric currents and non‐conjugate aurora: (1) Hemispherical differences in solar wind dynamo efficiency due to interplanetary magnetic field (IMF) Bx and dipole tilt angle leading to asymmetric region 1 currents in the two polar hemispheres, (2) interhemispheric currents induced by the penetration of IMF By into the closed nightside magnetosphere, and (3) hemispheric differences in ionospheric conductivity controlled by the dipole tilt angle inducing interhemispheric currents on closed field‐lines. We want to find out if our observations are consistent with these mechanisms. Our analysis shows that five features were consistent with the IMF By penetration mechanism, seven features consistent with the solar wind dynamo mechanism, three features consistent with the conductivity mechanism, and two features could not be explained by any of the three suggested mechanisms. Because two features were consistent with two different mechanisms, the numbers add up to 17 although the total number of features is 15. The analysis also shows the expected correlation between the magnitude of the longitudinal shift of conjugate points, ΔMLT, and the occurrence of non‐conjugate aurora consistent with the By mechanism.
Vessel‐encoded arterial spin labeling (VE‐ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance
Authors: Donahue Manus J. , Hussey Erin , Rane Swati , Wilson Tracy , van Osch Matthias , Hartkamp Nolan , Hendrikse Jeroen , Ally Brandon A. 
Published: May 2013

PurposeTo evaluate how flow territory asymmetry and/or the distribution of blood through collateral pathways may adversely affect the brain's ability to respond to age‐related changes in brain function. These patterns have been investigated in cerebrovascular disease; however, here we evaluated how flow‐territory asymmetry related to memory generally in older adults.Materials and MethodsA multi‐faceted MRI protocol, including vessel‐encoded arterial spin labeling capable of flow territory mapping, was applied to assess how flow territory asymmetry; memory performance (CERAD‐Immediate Recall); cortical cerebral blood flow (CBF), white matter lesion (WML) count, and cortical gray matter volume were related in older healthy control volunteers (HC; n = 15; age = 64.5 ± 7 years) and age‐matched mild cognitive impairment volunteers (MCI; n = 7; age = 62.7 ± 3.7 years).ResultsAn inverse relationship was found between memory performance and flow territory asymmetry in HC volunteers (P = 0.04), which reversed in MCI volunteers (P = 0.04). No relationship was found between memory performance and cortical tissue volume in either group (P > 0.05). Group‐level differences for HC volunteers performing above versus below average on CERAD‐I were observed for flow territory asymmetry (P < 0.02) and cortical volume (P < 0.05) only.ConclusionFindings suggest that flow territory asymmetry may correlate more sensitively with memory performance than CBF, atrophy and WML count in older adults. J. Magn. Reson. Imaging 2014;39:377–386. © 2013 Wiley Periodicals, Inc.
Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte‐phase image is a risk factor for hypervascular hepatocellular carcinoma
Authors: Ichikawa Shintaro , Ichikawa Tomoaki , Motosugi Utaroh , Sano Katsuhiro , Morisaka Hiroyuki , Enomoto Nobuyuki , Matsuda Masanori , Fujii Hideki , Araki Tsutomu 
Published: May 2013

PurposeTo determine whether the presence of a hypovascular nodule in the liver showing hypointensity on hepatocyte‐phase of gadoxetic acid‐enhanced magnetic resonance imaging (EOB‐MRI) is a risk factor for hypervascular hepatocellular carcinoma (HCC) in patients with chronic liver disease.Materials and MethodsForty‐one patients with pathologically confirmed hypervascular HCC and 41 age‐ and gender‐matched controls were retrospectively selected. These patients had undergone EOB‐MRI at least twice: the latest EOB‐MRI and EOB‐MRI performed more than 6 months earlier. History of hypervascular HCC, presence of a hypointense hypovascular nodule in previous hepatocyte‐phase MR images, percent prothrombin time, platelet count, serum levels of albumin, total bilirubin, aspartate aminotransferase, alanine aminotransferase, α‐fetoprotein, and protein induced by vitamin K absence‐II (PIVKA‐II) were variables evaluated by multivariate logistic regression analysis.ResultsMultivariate analysis revealed that serum albumin level (odds ratio [95% confidence interval], 0.19 [0.06–0.57]; P = 0.0024), history of hypervascular HCC (8.62 [2.71–32.8]; P = 0.0001), and presence of a hypointense hypovascular nodule (4.18 [1.18–17.2]; P = 0.0256) were significant risk factors for hypervascular HCC.ConclusionPatients with chronic liver disease showing a hypointense hypovascular nodule in the liver on hepatocyte‐phase EOB‐MRI have a high risk of HCC development. J. Magn. Reson. Imaging 2014;39:293–297. © 2013 Wiley Periodicals, Inc.
Study on a biomimetic enzyme‐linked immunosorbent assay method for rapid determination of trace acrylamide in French fries and cracker samples
Authors: Sun Qing , Xu Longhua , Ma Yue , Qiao Xuguang , Xu Zhixiang 
Published: May 2013

AbstractBACKGROUNDAcrylamide has attracted worldwide concern due to its neurotoxicity, genotoxicity, reproductive–development toxicity. It is necessary to develop an accurate and reliable analytical method to prevent the harm on the human health.RESULTSIn this study, a sensitive and fast analytical method of direct competitive biomimetic enzyme‐linked immunosorbent assay (BELISA) was developed using a hydrophilic imprinted membrane as biomimetic antibody. This novel imprinted membrane was directly synthesised on the well surface of MaxiSorp polystyrene 96‐well plates in an aqueous environment, and it exhibited high binding ability and specificity toward acrylamide. Under the optimal conditions, the established BELISA method had a good sensitivity (IC50, 8.0 ± 0.4 mg L−1) and a low limit of detection (IC15, 85.0 ± 4.2 µg L−1). The blank potato samples spiked with acrylamide at three levels of 100, 250 and 500 µg L−1 were extracted and determinate by the proposed method, and good recoveries ranging from 90.0% to 110.5% were obtained. This presented method was applied to the quantitative detection of the acrylamide in French fries and cracker samples. Also, the results were correlated well with that obtained by the gas chromatography method.CONCLUSIONWith good properties of high sensitivity, simple pre‐treatment and low cost, this BELISA could be a promising screening method in food sample analysis. © 2013 Society of Chemical Industry
Digestive recovery of sulfur‐methyl‐l‐methionine and its bioaccessibility in Kimchi cabbages using a simulated in vitro digestion model system
Authors: Lee Hae‐Rim , Cho Sun‐Duk , Lee Woon Kyu , Kim Gun‐Hee , Shim Soon‐Mi 
Published: May 2013

AbstractBACKGROUNDSulfur‐methyl‐l‐methionine (SMM) has been known to provide various biological functions such as radical scavenging effect, inhibition of adipocyte differentiation, and prevention of gastric mucosal damage. Kimchi cabbages are known to be a major food source providing SMM but its bioaccessibility has not been studied. The objective of current study was to determine both the digestive stability of SMM and the amount released from Kimchi cabbages under a simulated in vitro digestion model system.RESULTSThe in vitro digestion model system simulating a human gastrointestinal tract was carried out for measuring digestive recovery and bioaccessibility of SMM. SMM was quantified by using high‐performance liquid chromatography with a fluorescence detector. Recovery of an SMM standard after digestion was 0.68 and 0.65% for fasted and fed conditions, respectively, indicating that the digestive stability of the SMM standard was not affected by dietary energy or co‐ingested food matrix. The SMM standard was also significantly stable in acidic pH (P < 0.05). The bioaccessibility of SMM from Kimchi cabbages was measured under a fasted condition, resulted in 8.83, 14.71 and 10.88%, for salivary, gastric and small intestinal phases, respectively.CONCLUSIONResults from our study suggest that SMM from Kimchi cabbages, a component of food sources, is more bioavailable than SMM by itself. © 2013 Society of Chemical Industry
Effect of organic, conventional and mixed cultivation practices on soil microbial community structure and nematode abundance in a cultivated onion crop
Authors: Reilly Kim , Cullen Eileen , Lola‐Luz Theodora , Stone Dorothy , Valverde Juan , Gaffney Michael , Brunton Nigel , Grant James , Griffiths Bryan S 
Published: May 2013

AbstractBACKGROUNDResponses of the soil microbial and nematode community to organic and conventional agricultural practices were studied using the Teagasc Kinsealy Systems Comparison trial as the experimental system. The trial is a long‐term field experiment which divides conventional and organic agriculture into component pest‐control and soil treatment practices. We hypothesised that management practices would affect soil ecology and used community level physiological profiles, microbial and nematode counts, and denaturing gradient gel electrophoresis (DGGE) to characterise soil microbial communities in plots used for onion (Allium cepa L.) cultivation.RESULTSMicrobial activity and culturable bacterial counts were significantly higher under fully organic management. Culturable fungi, actinomycete and nematode counts showed a consistent trend towards higher numbers under fully organic management but these data were not statistically significant. No differences were found in the fungal/bacterial ratio. DGGE banding patterns and sequencing of excised bands showed clear differences between treatments. Putative onion fungal pathogens were predominantly sequenced under conventional soil treatment practices whilst putative soil suppressive bacterial species were predominantly sequenced from the organic pest‐control treatment plots.CONCLUSIONOrganic management increased microbial activity and diversity. Sequence data was indicative of differences in functional groups and warrants further investigation. © 2013 Society of Chemical Industry