bluuebunny/crossref_metadata_2025_split huggingface dataset:
How familiar are clinician teammates in the emergency department?
Authors: Patterson P Daniel , Pfeiffer Anthony J , Lave Judith R , Weaver Matthew D , Abebe Kaleab , Krackhardt David , Arnold Robert M , Yealy Donald M 
Published: December 2013

ObjectivesLack of familiarity between teammates is linked to worsened safety in high risk settings. The emergency department (ED) is a high risk healthcare setting where unfamiliar teams are created by diversity in clinician shift schedules and flexibility in clinician movement across the department. We sought to characterise familiarity between clinician teammates in one urban teaching hospital ED over a 22 week study period.MethodsWe used a retrospective study design of shift scheduling data to calculate the mean weekly hours of familiarity between teammates at the dyadic level, and the proportion of clinicians with a minimum of 2, 5, 10 and 20 h of familiarity at any given hour during the study period.ResultsMean weekly hours of familiarity between ED clinician dyads was 2 h (SD 1.5). At any given hour over the study period, the proportions of clinicians with a minimum of 2, 5, 10 and 20 h of familiarity were 80%, 51%, 27% and 0.8%, respectively.ConclusionsIn our study, few clinicians could be described as having a high level of familiarity with teammates. The limited familiarity between ED clinicians identified in this study may be a natural feature of ED care delivery in academic settings. We provide a template for measurement of ED team familiarity.
ESTABLISHMENT OF CLASS E1 MASS STANDARD OF 50 kg
Authors: YAO HONG , WANG JIAN , DING JINGAN , ZHONG RUILIN , REN XIAOPING 
Published: December 2013

Because of the equipment limit, the dissemination of large mass has been realized by a large amount of higher class of 20 kg weights since 1950s in China. But with improvement of the technique and customer's requirements, it is necessary to establish the mass standard of 50 kg weight. In 1990s, mass standard laboratory has set up Class E1 weight sets from 20 kg to 1 mg. To extend the mass capacity up to 50 kg of Class E1, it is not only to produce Class E1 50 kg weight and import a mass comparator, but also need to lift the heavy weight from weight box to balance receptor safely. Up to now, the mass comparator has been installed in Hepingli campus of NIM. Two pieces of Class E1 50 kg weights are determined by combination weighing method. A lifting device has been mounted close to the mass comparator in order to move the 50 kg easily.
Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
Authors: Marks Morgan A. , Chaturvedi Anil K. , Kelsey Karl , Straif Kurt , Berthiller Julien , Schwartz Stephen M. , Smith Elaine , Wyss Annah , Brennan Paul , Olshan Andrew F. , Wei Qingyi , Sturgis Erich M. , Zhang Zuo-Feng , Morgenstern Hal , Muscat Joshua , Lazarus Philip , McClean Michael , Chen Chu , Vaughan Thomas L. , Wunsch-Filho Victor , Curado Maria Paula , Koifman Sergio , Matos Elena , Menezes Ana , Daudt Alexander W. , Fernandez Leticia , Posner Marshall , Boffetta Paolo , Lee Yuan-Chin Amy , Hashibe Mia , D'Souza Gypsyamber 
Published: December 2013

Abstract
Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950.
Methods: A pooled analysis was conducted comprising individual-level data from nine case–control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls.
Results: Compared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal [adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06–1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71–1.25), but had no effect on the oral tongue cancer association.
Conclusions: These results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site.
Impact: The associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro- and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure. Cancer Epidemiol Biomarkers Prev; 23(1); 160–71. ©2013 AACR.
Inhibition of Protein Kinase C/Twist1 Signaling Augments Anticancer Effects of Androgen Deprivation and Enzalutamide in Prostate Cancer
Authors: Shiota Masaki , Yokomizo Akira , Takeuchi Ario , Imada Kenjiro , Kashiwagi Eiji , Song YooHyun , Inokuchi Junichi , Tatsugami Katsunori , Uchiumi Takeshi , Naito Seiji 
Published: December 2013

Abstract
Purpose: The progression of prostate cancer to metastatic and castration-resistant disease represents a critical step. We previously showed that the transcription factor Twist1, which promotes epithelial–mesenchymal transition, was involved in castration-resistant progression. Similarly, protein kinase C (PKC) has been implicated in both metastatic progression and castration resistance in prostate cancer.
Experimental Design: In this study, we aimed to elucidate the role of PKC/Twist1 signaling in castration resistance, and to apply this information to the development of a novel therapeutic concept using PKC inhibitor Ro31-8220 against prostate cancer using various prostate cancer cell lines.
Results: Androgen deprivation and the next-generation antiandrogen enzalutamide induced PKC activation and Twist1 expression, which were reversed by the PKC inhibitor Ro31-8220. Ro31-8220 suppressed cell proliferation in androgen-dependent prostate cancer LNCaP cells, which was augmented by its combination with androgen deprivation or enzalutamide. The favorable anticancer effects of the combination of Ro31-8220 and enzalutamide were also observed in castration-resistant C4-2 and 22Rv1 cells. Furthermore, PKC phosphorylation was elevated in castration-resistant and enzalutamide-resistant cells compared with their parental cells, leading to persistent sensitivity to Ro-31-8220 in castration- and enzalutamide-resistant cells.
Conclusions: Taken together, these findings indicate that PKC/Twist1 signaling contributes to castration resistance as well as enzalutamide resistance in prostate cancer, and suggest that therapeutics targeting PKC/Twist1 signaling, such as PKC inhibitors, represent a promising novel therapeutic strategy for prostate cancer, especially castration-resistant prostate cancer, when combined with enzalutamide. Clin Cancer Res; 20(4); 951–61. ©2013 AACR.
Diurnal Radiation Cycle Impact on the Pregenesis Environment of Hurricane Karl (2010)
Authors: Melhauser Christopher , Zhang Fuqing 
Published: December 2013

AbstractThrough convection-permitting ensemble and sensitivity experiments, this study examines the impact of the diurnal radiation cycle on the pregenesis environment of Hurricane Karl (2010). It is found that the pregenesis environmental stability and the intensity of deep moist convection can be considerably modulated by the diurnal extremes in radiation. Nighttime destabilization of the local and large-scale environment through radiative cooling may promote deep moist convection and increase the genesis potential, likely enhancing the intensity of the resultant tropical cyclones. Modified longwave and shortwave radiation experiments found tropical cyclone development to be highly sensitive to the periodic cycle of heating and cooling, with suppressed formation in the daytime-only and no-radiation experiments and quicker intensification compared with the control for nighttime-only experiments.
Do newspaper reports of suicides comply with standard suicide reporting guidelines? A study from Bangalore, India
Authors: Chandra Prabha S , Doraiswamy Padmavathy , Padmanabh Anuroopa , Philip Mariamma 
Published: December 2013

Background: Several countries have prescribed standard guidelines for media professionals on suicide reporting. However, the implementation of these guidelines has been varied. Suicide rates in South Asia are one of the highest in the world, and it is known that media guidelines for suicide reporting are not followed adequately. However, there are no published reports available from this region. Aim: This study aimed at assessing newspaper reports of suicide for quality of reporting based on standard reporting guidelines and to study differences between English and vernacular ( Kannada) newspapers in Bangalore, South India. Methods: A total of 341 newspaper reports of suicide from 550 newspapers (3 English and 3 Kannada) over 3 months were systematically assessed for compliance with reporting guidelines. Each report was evaluated on 2 domains and 36 parameters. Data were analyzed for frequency of inappropriate reporting and patterns compared between vernacular and English newspapers. Results: In all, 87% of the reports were those of completed suicide. Non-compliant reporting – method of suicide was reported in 89% and 32% of reports were in prominent pages of the newspaper, 95% mentioned gender, 90% reported the name, 80% reported age and suicide location, 75% reported life events related to suicide, 70% reported occupation, 69% had headline explicity on suicide and 61% reported monocausality. Only 16% reported mental disorder related to suicide, and less than 3% included information on suicide prevention and helplines. Vernacular papers showed significantly better compliance in 16 of the 20 areas. However, protective characteristics were better reported in English newspapers. Conclusion: Majority of reports on suicides in newspapers from Bangalore did not comply with standard guidelines of reporting. There is a strong need to evolve local guidelines and mechanisms for ensuring responsible reporting which have important implications in prevention of suicide.
General health workers’ description of mental health problems and treatment approaches used in Papua New Guinea
Authors: Koka Betty E , Deane Frank P , Lyons Geoffrey CB , Lambert Gordon 
Published: December 2013

Background: Papua New Guinea is a developing country with limited resources for specialist mental health services. Little is known about the mental health and treatment services of Papua New Guinea. Aim: The aim of this study was to clarify the presenting mental health problems encountered by Papua New Guinean health workers and the common treatment approaches used. Methods: A total of 203 Papua New Guinean health workers completed a retrospective quantitative survey about their three most recent mental health patients. The survey asked about presenting symptomatology, diagnoses (including culture-bound diagnoses) and treatment approaches. Results: The major presenting mental health problems for males included schizophrenia, substance use disorder, sorcery and spirit possession. Depression was the most common diagnoses for women, followed by sorcery and somatisation. Over 65% of patients were prescribed psychotropic medication, over 50% received some form of psychological intervention and 28% were receiving traditional treatments. Conclusions: Somatic symptoms are common among both male and female Papua New Guineans; however, males may be more likely to present with psychotic symptoms and females with mood-related problems. Schizophrenia and depression are commonly identified with substance use disorder more problematic among males. Culture-specific explanations and treatment are commonly used.
The Contribution of Gang Membership to the Victim–Offender Overlap
Authors: Pyrooz David C. , Moule Richard K. , Decker Scott H. 
Published: December 2013

Objective: Although a vast literature has investigated the consequences of gang membership for offending and victimization, little is known about the contribution of gang membership to the victim–offender overlap. We advance a group process theoretical model and provide an empirical extension of the victim–offender overlap to gang membership. Method: Using data gathered from 621 respondents in five cities, the contribution of gang membership to the victim–offender overlap is determined by examining (1) a typology of four victim–offender arrangements using multinomial logistic regression modeling and (2) the latent propensity for violent offending and victimization using multilevel item response theory modeling. Results: Gang members were over twice as likely as nongang members to be both victims and offenders, even after adjusting for low self-control, adherence to street codes, and routine activities. Neither contemporary theoretical perspectives on the overlap nor the reciprocal relationship between violent outcomes eliminated the association of gang membership with violent victimization and violent offending. Conclusion: By theoretically and empirically integrating gang membership into current knowledge on the victim–offender overlap, the results suggest that there is much to be gained for research and practice by unpacking the features of criminal and deviant networks.
Reduced neck-shoulder muscle strength and aerobic power together with increased pericranial tenderness are associated with tension-type headache in girls: A case-control study
Authors: Tornoe Birte , Andersen Lars L , Skotte Jørgen H , Jensen Rigmor , Gard Gunvor , Skov Liselotte , Hallström Inger 
Published: December 2013

Background Tension-type headaches (TTH) are common among children worldwide and mean a potential risk of disability and medication overuse headache. The associated mechanisms, however, remain unsolved. Our study investigated muscle strength in the neck-shoulder region, aerobic power and pericranial tenderness in girls with TTH compared with healthy controls. Methods A blinded case-control study comprising 41 girls with TTH and 41 age-matched healthy controls. Standardised testing of isometric maximal voluntary contraction (MVC) and force steadiness of neck flexion and extension, as well as MVC and rate-of-force development of dominant shoulder, was conducted. VO2 max was recorded by a submaximal ergometer test and pericranial tenderness by standardised manual palpation. Logistic regression analyses were applied. Results Girls with TTH demonstrated significantly higher pericranial tenderness than controls, in correlation with headache frequency ( r = 0.66, p < 0.001). Results indicated that the odds ratio of girls having headache are 7.6 (95% CI 1.4–40.9) for weak to strong shoulder muscles; weak to average neck-shoulder strength OR 3.1 (95% CI 1.2–8.1); neck flexion strength OR 1.3 (95% CI 1.0–1.6) and 5.2 (95% CI: 1.4–19.6) for each unit of decrease in VO2 max. Conclusions Reduced neck-shoulder strength and aerobic power together with increased pericranial tenderness are associated with TTH in girls. Future interventions should be directed towards health promoting patient educational programmes on enhanced physical exercising. Much more exact and detailed research in young girls and boys are needed.
Prolactinoma-associated headache and dopamine agonist treatment
Authors: Kallestrup Mia-Maiken , Kasch Helge , Østerby Toke , Nielsen Edith , Jensen Troels S , Jørgensen Jens OL 
Published: December 2013

Aim The aim of this article is to investigate the phenotype and etiology of prolactinoma-associated headache as well as present and discuss the plausible pain-relieving effect of dopamine agonist treatment. Methods In this case-based audit we included 11 patients with prolactinomas and one patient with idiopathic hyperprolactinemia presenting with headache that subsequently improved or resolved after dopamine agonist treatment. Results A significant ipsilateral location of tumor mass and reported headache symptoms was observed ( p = 0.018). After dopamine agonist treatment seven out of 12 patients became pain free within 2.5 months; after one year of treatment 11 out of 12 reported headache improvement or resolution. Average tumor volume reduction after treatment was 47 ± 22% during 9.5 ± 8.4 months of follow-up. There was no significant association between headache relief and tumor shrinkage ( p = 0.43) or normalization of serum prolactin ( p = 1.00), respectively. Conclusions 1) The significant association between lateralization of tumor and headache suggests a mechanical origin of the headache, 2) headache responded to dopamine agonist treatment in most patients, and 3) our observations encourage future prospective controlled trials to investigate the role of hyperprolactinemia in the pathogenesis of headache as well as the therapeutic effects of dopamine agonists.
Promoting Pharmacy-Based Referrals to the Tobacco Quitline
Authors: Wahl Kimberly R. , Woolf Brittany L. , Hoch Matthew A. , Zillich Alan J. , Hudmon Karen Suchanek 
Published: December 2013

Objective: To conduct a pilot study of a student-delivered academic detailing initiative to promote brief, pharmacy-based tobacco cessation interventions, and referrals to the tobacco quitline. Methods: Pharmacy students (n = 11) received training and delivered academic detailing sessions for promoting brief tobacco cessation interventions at community pharmacies (n = 37). Six months after the session, a survey was faxed to each pharmacy to assess (1) the quality and acceptance of the academic detailing session and the materials provided during the session and (2) tobacco cessation counseling perceptions and practices. Results: Pharmacists from 30 (81%) sites responded to the survey; of these, 37% reported that they increased the number of patients asked about smoking since the academic detailing session, 70% reported an increase in the number of participants advised to quit smoking, 57% reported an increase in the number of patients counseled, and 50% reported routinely providing referrals to the tobacco quitline. Conclusion: pharmacy students are capable of providing academic detailing for brief tobacco cessation interventions in community pharmacies. Results of this pilot study suggest a positive impact of this service on pharmacists’ counseling behavior for tobacco cessation.
Population-level associations between antiretroviral therapy scale-up and all-cause mortality in South Africa
Authors: Larson Elysia , Bendavid Eran , Tuoane-Nkhasi Maletela , Mbengashe Thobile , Goldman Thurma , Wilson Melinda , Klausner Jeffrey D 
Published: December 2013

Summary Our aim was to describe the association between increasing access to antiretroviral therapy and all-cause mortality in South Africa from 2005 to 2009. We undertook a longitudinal, population-level study, using antiretroviral monitoring data reported by PEPFAR implementing partners and province-level and national all-cause mortality records from Statistics South Africa (provider of official South African government statistics) to analyse the association between antiretroviral therapy and mortality. Using mixed effects models with a random intercept for province, we estimated the contemporaneous and lagging association between antiretroviral therapy and all-cause mortality in South Africa. We also conducted subgroup analyses and estimated the number of deaths averted. For each 100 HIV-infected individuals on antiretroviral therapy reported by PEPFAR implementing partners in South African treatment programmes, there was an associated 2.9 fewer deaths that year (95% CI: 1.5, 4.2) and 6.3 fewer deaths the following year (95% CI: 4.6, 8.0). The associated decrease in mortality the year after treatment reporting was seen in both adults and children, and men and women. Treatment provided from 2005 to 2008 was associated with 28,305 deaths averted from 2006 to 2009. The scale-up of antiretroviral therapy in South Africa was associated with a significant reduction in national all-cause mortality.
Hypertrophic pachymeningitis associated with cerebral spinal fluid hypovolemia as initial presentation of systemic lupus erythematous
Authors: Sanchez-Garcia ME , Gomez-Delgado F , Gomez-Garduño A , Blanco-Molina A , Puebla RA Fernandez de la 
Published: December 2013

We report a case of a 61-year-old man with thickening of the dura mater associated with the presence of subdural collections as a consequence of cerebral spinal fluid hypovolemia (CSFH) and hypertrophic pachymeningitis (HP) as presentation of systemic lupus erythematous (SLE). The patient complained about fatigue, musculoskeletal pain, headache and skin lesions. In the laboratory tests minimal normocytic anemia, mild leukopenia, polyclonal hypergammaglobulinemia and antinuclear antibodies (ANA), anti-double-stranded DNA antibodies (dsDNA), antibodies against extractable nuclear antigens (ENA) type SSA-Ro, anti-Smith antigen antibodies (anti-Sm) and anti-ribonucleoprotein antibodies (anti-RNP) were detected. Cranial magnetic resonance imaging (MRI), with and without gadolinium enhancement, revealed generalized thickening of the dura mater more severe at the right parieto-occipital lobes with the presence of subdural collections. The patient was diagnosed with SLE associated both with CSFH and HP. A conservative treatment with prednisone 60 mg daily, mycophenolate mofetil (MMF) 1 g daily and hydroxychloroquine 200 mg twice a day was started with significant clinical and radiological improvement (almost complete resolution of the subdural collections and clear decrease of meningeal thickness). The authors emphasize that HP associated with CSFH in the context of SLE is a rare entity, which makes this case unique.