bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Brominations with Pr4NBr9 as a Solid Reagent with High Reactivity and Selectivity.
Authors: Beck Thorsten M. , Haller Heike , Streuff Jan , Riedel Sebastian 
Published: August 2014

AbstractThe reagent is used for rapid bromination of alkenes (I), enones (III), alkynes (VI), acetophenone (VIII), and arenes (XI), (XIII), and (XV) in a regio‐ and/or stereoselective manner in high yields.
ChemInform Abstract: Stereospecific Hydrodehalogenation of Alkenyl Bromides: A New Approach to the Synthesis of (E)‐Alkenes.
Authors: Chelucci Giorgio 
Published: August 2014

AbstractA variety of (E)‐alkenes (II) and (IV) is obtained by Pd‐catalyzed hydrodebromination of bromides (I) and (III) with NaBH4 and TMEDA.
ChemInform Abstract: CuO Nanoparticles as Effective Reusable Heterogeneous Catalyst for S‐Arylation Reactions.
Authors: Yavari Issa , Sodagar Esmat , Nematpour Manijeh 
Published: August 2014

AbstractCuO nanoparticles are an efficient and inexpensive catalyst for C—S cross coupling reactions of manolonitrile‐CS2 adduct with a variety of aryl halides.
ChemInform Abstract: Three‐Component Reactions of Aromatic Aldehydes and Two Different Nucleophiles and Their Leaving Ability‐Determined Downstream Conversions of the Products.
Authors: Li Minghao , Taheri Amir , Liu Meng , Sun Shaohuan , Gu Yanlong 
Published: August 2014

AbstractL‐Proline catalyzes the three‐component reactions of benzaldehydes, activated methylene compounds and nucleophiles.
ChemInform Abstract: A Novel P450‐Based Biocatalyst for the Selective Production of Chiral 2‐Alkanols.
Authors: von Buehler Clemens J. , Urlacher Vlada B. 
Published: August 2014

AbstractThe P450 monooxygenase CYP154A8 from Nocardia farcinica is successfully applied as a biocatalyst in the regio‐ and enantioselective hydroxylation of alkanes (I) to (S)‐2‐alkanols (II).
ChemInform Abstract: Improved Zinc‐Catalyzed Simmons—Smith Reaction: Access to Various 1,2,3‐Trisubstituted Cyclopropanes.
Authors: Levesque Eric , Goudreau Sebastien R. , Charette Andre B. 
Published: August 2014

AbstractThe high reactivity of aryldiazomethanes towards zinc allows for catalytical generation of the intermediary carbenoids.
ChemInform Abstract: Silver‐Catalyzed Alkyne Activation: The Surprising Ligand Effect.
Authors: Su Yijin , Lu Mei , Dong Boliang , Chen Hao , Shi Xiaodong 
Published: August 2014

AbstractThis Ag‐catalysis is based on a strong ligand effect requiring a ratio of BINAP:Ag of 1:2 for excellent yields and moderate enantioselectivities.
ChemInform Abstract: Air‐Stable Gold Nanoparticles Ligated by Secondary Phosphine Oxides for the Chemoselective Hydrogenation of Aldehydes: Crucial Role of the Ligand.
Authors: Cano Israel , Chapman Andrew M. , Urakawa Atsushi , van Leeuwen Piet W. N. M. 
Published: August 2014

AbstractThe synthesis of novel air‐stable gold nanoparticles employing tert‐butyl(naphthalene‐1‐yl)phosphine oxide as supporting ligand and its characterization using a wide range of techniques is reported.
ChemInform Abstract: A Rapid, Highly Efficient, and General Protocol for the Synthesis of Functionalized Triarylmethanes: A Straightforward Access for the Synthesis of (‐)‐Tatarinoid C.
Authors: Babu B. Madhu , Thakur Pramod B. , Nageswara Rao N. , Santosh Kumar G. , Meshram H. M. 
Published: August 2014

AbstractBF3·Et2O‐mediated Friedel‐Crafts alkylation is used for the synthesis of triarylmethanes from aldehydes and di‐ or trimethoxybenzenes.
ChemInform Abstract: Synthesis of CF3‐Containing 3,3′‐Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2‐Trifluorodiazoethane.
Authors: Li Tian‐Ren , Duan Shu‐Wen , Ding Wei , Liu Yi‐Yin , Chen Jia‐Rong , Lu Liang‐Qiu , Xiao Wen‐Jing 
Published: August 2014

AbstractThis is the first example of [3 + 2] cycloaddition/ ring contraction sequence under transition‐metal‐free conditions yielding the title spiro compounds.
ChemInform Abstract: Alkynyliodonium Salt Mediated Alkynylation of Azlactones: Fast Access to Cα‐Tetrasubstituted α‐Amino Acid Derivatives.
Authors: Finkbeiner Peter , Weckenmann Nicole M. , Nachtsheim Boris J. 
Published: August 2014

AbstractCysteine and serine derivatives are not tested since their azlactones are synthetically not accessible from their protected amino acid precursors.
ChemInform Abstract: Regio‐ and Stereoselective 1,2‐Dihydropyridine Alkylation/Addition Sequence for the Synthesis of Piperidines with Quaternary Centers.
Authors: Duttwyler Simon , Chen Shuming , Lu Colin , Mercado Brandon Q. , Bergman Robert G. , Ellman Jonathan A. 
Published: August 2014

AbstractThis is the first example of a C‐alkylation of 1,2‐dihydropyridines with alkyl triflates and Michael acceptors to yield products with quaternary stereocenters with high regio‐ and diastereoselectivity.
ChemInform Abstract: Preparation of 6‐Unsubstituted 3,4‐Dihydropyrimidin‐2(1H)‐ones and 2‐(Arylamino)pyrimidines.
Authors: Terentjeva S. , Muceniece D. , Lusis V. 
Published: August 2014

AbstractA novel series of 6‐unsubstituted dihydropyrimidines (IV) are synthesized via a Biginelli reaction and transformed into previously unknown 2‐arylaminopyrimidines (V).
ChemInform Abstract: C—H Bond Arylation in the Synthesis of Aryltetralin Lignans: A Short Total Synthesis of Podophyllotoxin.
Authors: Ting Chi P. , Maimone Thomas J. 
Published: August 2014

AbstractThe preparation of title compound (IV) starts from 6‐bromopiperonal (not shown) and involves a Pd‐catalyzed C(sp3)—H arylation as the key step‐
ChemInform Abstract: Recent Advances in Porous Polyoxometalate‐Based Metal—Organic Framework Materials
Authors: Du Dong‐Ying , Qin Jun‐Sheng , Li Shun‐Li , Su Zhong‐Min , Lan Ya‐Qian 
Published: August 2014

AbstractReview: classification, synthesis strategies, and applications, especially in the field of catalysis; 125 refs.
ChemInform Abstract: Micro‐Emulsion Based Emulgel: A Novel Topical Drug Delivery System
Authors: Ashara Kalpesh Chhotalal , Paun Jalpa S. , Soniwala Moinuddin M. , Chavada Jayant R. , Mori Nitin Merubhai 
Published: August 2014

AbstractReview: 39 refs.
Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck
Authors: Saba Nabil F. , Hurwitz Selwyn J. , Magliocca Kelly , Kim Sungjin , Owonikoko Taofeek K. , Harvey Donald , Ramalingam Suresh S. , Chen Zhengjia , Rogerio Jackie , Mendel Jennifer , Kono Scott A. , Lewis Colleen , Chen Amy Y. , Higgins Kristin , El‐Deiry Mark , Wadsworth Trad , Beitler Jonathan J. , Shin Dong M. , Sun Shi‐Yong , Khuri Fadlo R. 
Published: August 2014

BACKGROUNDPlatinum‐based therapy combined with cetuximab is standard first‐line therapy for recurrent or metastatic squamous cell carcinoma of the head and neck (RMSCCHN). Preclinical studies have suggested that mammalian target of rapamycin inhibitors may overcome resistance to epidermal growth factor receptor blockers and may augment cetuximab antitumor activity. We conducted a phase 1b trial of carboplatin, cetuximab, and everolimus for untreated RMSCCHN.METHODSPatients received carboplatin (area under the curve = 2 mg/ml/min; 3 weeks on, 1 week off), cetuximab (with a loading dose of 400 mg/m2and then 250 mg/m2weekly), and dose‐escalating everolimus (2.5, 5.0, 7.5, and 10 mg/day) with a 3+3 design. After 4 cycles, patients without progression continued cetuximab/everolimus until progression or intolerable toxicity. Patients (age ≥ 18 years) had previously untreated, unresectable RMSCCHN not amenable to radiotherapy and an Eastern Cooperative Oncology Group performance status of 0 to 2.RESULTSThe study enrolled 20 patients (male/female = 18/2) with RMSCCHN; the median age was 65 years (44‐75 years). Thirteen patients received everolimus (male/female = 92%). Two of 6 patients receiving 2.5 mg/day experienced dose‐limiting toxicity (DLT) with grade 3 hyponatremia and nausea. In 7 patients receiving de‐escalated everolimus (2.5 mg every other day), grade 3 hyperglycemia produced DLT in 1 of 6 patients. The objective response rate (RR) was 61.5% (all partial responses). Progression‐free survival (PFS) was 8.15 months. The pharmacokinetics of everolimus was described with a 2‐compartment mixed‐effects model. There was a significant correlation between tumor p‐p44/42 staining and response (P = .044) and a marginally significant correlation between phosphorylated mammalian target of rapamycin and overall survival.CONCLUSIONSThe maximum tolerated dose of everolimus with cetuximab and carboplatin was 2.5 mg every other day. The regimen was associated with an encouraging RR and PFS, and this suggested possible clinical efficacy in a select group of patients with squamous cell carcinoma of the head and neck.Cancer2014;120:3940–3951.©2014 American Cancer Society.
Changes of ventricular and peripheral performance in patients with heart failure and normal ejection fraction: insights from ergometry stress echocardiography
Authors: Wang Jing , Fang Fang , Wai‐Kwok Yip Gabriel , Sanderson John E , Lee Pui‐Wai , Feng Wei , Xie Jun‐Min , Luo Xiu‐Xia , Lam Yat‐Yin 
Published: August 2014

AimsWe assessed the left ventricular (LV) and peripheral performance at rest and during exercise in healthy and heart failure subjects with normal ejection fraction (HFNEF) or with reduced ejection fraction (HFREF).MethodsAll subjects received echocardiography at rest and with bicycle Ergometer exercise. The exercise images for two‐dimensional speckle tracking were acquired with submaximal heart rate of 90–100 beats/min, while images for M‐mode and tissue Doppler imaging were stored with attainment of >85% of predicted heart rate.ResultsA total of 80 HFNEF, 50 HFREF and 50 controls were studied. There was progressive decrease of two‐dimensional global circumferential, radial and longitudinal strains (GCS, GRS and GLS), M‐mode and tissue Doppler imaging long‐axis parameters from controls, HFNEF to HFREF patients (all P < 0.05) at rest and on exercise. The degree of exercise‐induced, long‐axis augmentation (GLS and M‐mode long axis excursion) decreased progressively from controls, HFNEF to HFREF subjects (all P < 0.05), while the increase in GCS and GRS was similar in all groups. The ventricular–arterial coupling ratio did not change in HFREF but reduced in HFNEF and controls during exercise (P < 0.01). All subjects had a similar resting heart rate, but patients exhibited chronotropic non‐competence during exercise (P < 0.001).ConclusionsVentricular and peripheral dysfunction was evident in HFNEF at rest and deteriorated during exercise. The HFNEF patients had significantly impaired long‐axis augmentation at stress that was intermediate between HFREF patients and controls. These findings have relevance to generation of symptoms on exercise in both HFNEF and HFREF.
The St Vincent's potentially inappropriate medicines study: development of a disease‐specific consensus list and its evaluation in ambulatory heart failure care
Authors: Bermingham Margaret , Ryder Mary , Travers Bronagh , Edwards Nuala , Lalor Lorraine , Kelly Deirdre , Gallagher Joseph , O'Hanlon Rory , McDonald Kenneth , Ledwidge Mark 
Published: August 2014

AimsHeart failure (HF) patients may be at risk of prescription of potentially inappropriate medicines (PIMs) yet no disease‐specific list is available to assess PIM use in this population. A Consensus Potentially Inappropriate Medicines in Heart Failure (PIMHF) list was developed, assessed, and compared with an established, general tool in an ambulatory HF population.Methods and resultsThe Consensus PIMHF list was compiled using modified Delphi methodology with a multidisciplinary team. The list consisted of 11 items. The medication profile of 350 patients was assessed. The association of a Consensus PIMHF item use over a median follow‐up period of 1.8 (interquartile range 1.3–2.1) years with the primary endpoint of death, acute hospitalization, or unscheduled outpatient visit was examined. Fifty‐one patients (14.6%) were prescribed ≥1 Consensus PIMHF item. In univariable analysis, patients prescribed ≥1 Consensus PIMHF item were 58% more likely to experience the primary endpoint than those with none [95% confidence interval (CI) 1.02–2.45]. When adjusted for age, sex, and HF severity, this difference remained [hazard ratio (HR) 1.88, 95% CI 1.16–3.06] and these associations were in contrast to the use of a more general tool (HR 1.24, 95% CI 0.83–1.84). However, when further adjusted to include co‐morbidity score and polypharmacy, there was no association with outcome using either tool (HR 1.40, 95% CI 0.83–2.38; HR 1.05, 95% CI 0.69–1.60, respectively).ConclusionThe Consensus PIMHF list provides the first HF‐specific medicines review tool. These results provide some support for more disease‐specific tools with limited lists of PIMs to rationalize medicines management in HF. However, more prospective work on the application of these tools in practice is needed.
Effect of variety and processing method on functional properties of traditional sweet potato flour (“elubo”) and sensory acceptability of cooked paste (“amala”)
Authors: Fetuga Ganiyat , Tomlins Keith , Henshaw Folake , Idowu Michael 
Published: August 2014

Abstract“Amala” is a generic term in Nigeria, used to describe a thick paste prepared by stirring flour (“elubo”) from yam, cassava or unripe plantain, in hot water, to form a smooth consistency. In order to overcome its high perishability and increase the utilization of sweet potato roots, three varieties of sweet potato roots were processed into flour using two methods. The interactive effect of variety and the processing method had a significant effect (P < 0.05) on all the functional properties of the flour except yellowness, setback viscosity, and peak time. Acceptable sweet potato “amala” with average sensory acceptability score of 7.5 were obtained from yellow‐fleshed varieties irrespective of the processing method. Flour that produced acceptable “amala” were characterized by lower values of protein (2.20–3.94%), fiber (1.30–1.65%), total sugar (12.41–38.83 μg/mg), water absorption capacity (168–215 g/100 g), water solubility (8.29–14.65%), swelling power (0.52–0.82 g/g), and higher peak time (6.9–8.7 min).
The role of epigenetics in cognitive ageing
Authors: Mather Karen A. , Kwok John B. , Armstrong Nicola , Sachdev Perminder S. 
Published: August 2014

ObjectiveAs the population is ageing, a better understanding of the underlying causes of age‐related cognitive decline (cognitive ageing) is required. Epigenetic dysregulation is proposed as one of the underlying mechanisms for cognitive ageing. We review the current knowledge on epigenetics and cognitive ageing and appraise the potential of epigenetic preventative and therapeutic interventions.DesignArticles on cognitive ageing and epigenetics in English were identified.ResultsEpigenetic dysregulation occurs with cognitive ageing, with changes in histone post‐translational modifications, DNA methylation and non‐coding RNA reported. However, human studies are lacking, with most being cross‐sectional using peripheral blood samples. Pharmacological and lifestyle factors have the potential to change aberrant epigenetic profiles; but few studies have examined this in relation to cognitive ageing.ConclusionsThe relationship between epigenetic modifications and cognitive ageing is only beginning to be investigated. Epigenetic dysregulation appears to be an important feature in cognitive ageing, but whether it is an epiphenomenon or a causal factor remains to be elucidated. Clarification of the relationship between epigenetic profiles of different cell types is essential and would determine whether epigenetic marks of peripheral tissues can be used as a proxy for changes occurring in the brain. The use of lifestyle and pharmacological interventions to improve cognitive performance and quality of life of older adults needs more investigation. Copyright © 2014 John Wiley & Sons, Ltd.
A dual‐task design of corrosion‐controlling and osteo‐compatible hexamethylenediaminetetrakis‐ (methylene phosphonic acid) (HDTMPA) coating on magnesium for biodegradable bone implants application
Authors: Zhao Sheng , Chen Yingqi , Liu Bo , Chen Meiyun , Mao Jinlong , He Hairuo , Zhao Yuancong , Huang Nan , Wan Guojiang 
Published: August 2014

ABSTRACTMagnesium as well as its alloys appears increasingly as a revolutionary bio‐metal for biodegradable implants application but the biggest challenges exist in its too fast bio‐corrosion/degradation. Both corrosion‐controllable and bio‐compatible Mg‐based bio‐metal is highly desirable in clinic. In present work, hexamethylenediaminetetrakis (methylenephosphonic acid) [HDTMPA, (H2O3P−CH2)2−N−(CH2)6−N−(CH2−PO3H2)2], as a natural and bioactive organic substance, was covalently immobilized and chelating‐deposited onto Mg surface by means of chemical conversion process and dip‐coating method, to fullfill dual‐task performance of corrosion‐protective and osteo‐compatible functionalities. The chemical grafting of HDTMPA molecules, by participation of functional groups on pretreated Mg surface, ensured a firmly anchored base layer, and then sub‐sequential chelating reactions of HDTMPA molecules guaranteed a homogenous and dense HDTMPA coating deposition on Mg substrate. Electrochemical corrosion and immersion degradation results reveal that the HDTMPA coated Mg provides a significantly better controlled bio‐corrosion/degradation behavior in phosphate buffer saline solution as compared with untreated Mg from perspective of clinic requirement. Moreover, the HDTMPA coated Mg exhibits osteo‐compatible in that it induces not only bioactivity of bone‐like apatite precipitation but also promotes osteoblast cells adhesion and proliferation. Our well‐controlled biodegradable and biocompatible HDTMPA modified Mg might bode well for next generation bone implant application. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1640–1652, 2015.
Development of wheat glutenin nanoparticles and their biodistribution in mice
Authors: Reddy Narendra , Shi Zhen , Xu Helan , Yang Yiqi 
Published: August 2014

AbstractWheat glutenin nanoparticles intended for targeted drug delivery were biocompatible and were detected in the kidney, liver, and spleen in mice. Protein‐based nanoparticles are preferred for therapeutic drug and gene delivery owing to their biocompatibility and ability to load various types of drugs. However, proteins such as a collagen and albumin are unstable in aqueous environments and are not ideal for drug delivery applications. Wheat glutenin has been demonstrated to be biocompatible and have good stability under aqueous conditions. Films and fibers have been made from wheat glutenin for medical applications but there are no reports on developing micro‐ or nanoparticles. In this research, wheat glutenin nanoparticles (70–140 nm) were prepared and the stability of the nanoparticles under various physiological conditions was investigated. Nanoparticles were fluorescently labeled and later injected into mice and the ability of the nanoparticles to penetrate into the cells in various organs was studied. Strong acidic or alkaline conditions provided glutenin nanoparticles with low diameters and the particles were more stable under the pH 7 rather than pH of 4. Glutenin nanoparticles were predominantly found in the liver in mice. Our in vivo and in vitro studies suggest that glutenin nanoparticles are suitable for drug delivery applications. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1653–1658, 2015.
The effect of calcium phosphate composite scaffolds on the osteogenic differentiation of rabbit dental pulp stem cells
Authors: Ling Ling E. , Feng Lin , Liu Hong‐Chen , Wang Dong‐Sheng , Shi Zhan‐Ping , Wang Jun‐Cheng , Luo Wei , Lv Yan 
Published: August 2014

AbstractThe objective of this study is to compare the effects of the two calcium phosphate composite scaffolds on the attachment, proliferation, and osteogenic differentiation of rabbit dental pulp stem cells (DPSCs). One nano‐hydroxyapatite/collagen/poly (l‐lactide) (nHAC/PLA), imitating the composition and the micro‐structure characteristics of the natural bone, was made by Beijing Allgens Medical Science & Technology Co., Ltd. (China). The other beta‐tricalcium phosphate (β‐TCP), being fully interoperability globular pore structure, was provided by Shanghai Bio‐lu Biomaterials Co, Ltd. (China). We compared the absorption water rate and the protein adsorption rate of two scaffolds and the characterization of DPSCs cultured on the culture plate and both scaffolds under osteogenic differentiation media (ODM) treatment. The constructs were then implanted subcutaneously into the back of severely combined immunodeficient (SCID) mice for 8 and 12 weeks to compare their bone formation capacity. The results showed that the ODM‐treated DPSCs expressed osteocalcin (OCN), bone sialoprotein (BSP), type I collagen (COLI) and osteopontin (OPN) by immunofluorescence staining. Positive alkaline phosphatase (ALP) staining, calcium deposition and calcium nodules were also observed on the ODM‐treated DPSCs. The absorption water rate and protein adsorption rate of nHAC/PLA was significantly higher than β‐TCP. The initial attachment of DPSCs seeded onto nHAC/PLA was significantly higher than that onto β‐TCP; and the proliferation rate of the cells was also significantly higher than that of β‐TCP on 1, 3, and 7 days of cell culture. The ALP activity, calcium/phosphorus content and mineral formation of DPSCs + β‐TCP were significantly higher than DPSCs + nHAC/LA. When implanted into the back of SCID mice, nHAC/PLA alone had no new bone formation, newly formed mature bone and osteoid were only observed in β‐TCP alone, DPSCs + nHAC/PLA and DPSCs + β‐TCP, and this three groups displayed increased bone formation over the 12‐week period. The percentage of total bone formation area had no difference between DPSCs + β‐TCP and DPSCs + nHAC/PLA at each time point, but the percentage of mature bone formation area of DPSCs + β‐TCP was significantly higher than that of DPSCs + nHAC/PLA. Our results demonstrated that the DPSCs on nHAC/PLA had a better proliferation, and that the DPSCs on β‐TCP had a more mineralization in vitro, much more newly formed mature bones in vivo were presented in DPSCs + β‐TCP group. These findings have provided a further knowledge that scaffold architecture has different influence on the attachment, proliferation and differentiation of cells. This study may provide insight into the clinical periodontal bone tissue repair with DPSCs + β‐TCP construct. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part: 103A: 1732–1745, 2015.
Collagen scaffolds combined with collagen‐binding ciliary neurotrophic factor facilitate facial nerve repair in mini‐pigs
Authors: Lu Chao , Meng Danqing , Cao Jiani , Xiao Zhifeng , Cui Yi , Fan Jingya , Cui Xiaolong , Chen Bing , Yao Yao , Zhang Zhen , Ma Jinling , Pan Juli , Dai Jianwu 
Published: August 2014

AbstractThe preclinical studies using animal models play a very important role in the evaluation of facial nerve regeneration. Good models need to recapitulate the distance and time for axons to regenerate in humans. Compared with the most used rodent animals, the structure of facial nerve in mini‐pigs shares more similarities with humans in microanatomy. To evaluate the feasibility of repairing facial nerve defects by collagen scaffolds combined with ciliary neurotrophic factor (CNTF), 10‐mm‐long gaps were made in the buccal branch of mini‐pigs' facial nerve. Three months after surgery, electrophysiological assessment and histological examination were performed to evaluate facial nerve regeneration. Immunohistochemistry and transmission electron microscope observation showed that collagen scaffolds with collagen binding (CBD)‐CNTF could promote better axon regeneration, Schwann cell migration, and remyelination at the site of implant device than using scaffolds alone. Electrophysiological assessment also showed higher recovery rate in the CNTF group. In summary, combination of collagen scaffolds and CBD‐CNTF showed promising effects on facial nerve regeneration in mini‐pig models. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1669–1676, 2015.