bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple myeloma in a captive lion (<i>Panthera leo</i>)
Authors: Tordiffe Adrian S.W. , Cassel Nicky , Lane Emily P. , Reyers Fred 
Published: September 2013

Multiple myeloma is a rare, systemic proliferation of neoplastic plasma cells. A case was reported in an 11-year-old male captive lion (Panthera leo) at the National Zoological Gardens of South Africa, Pretoria. The classic features of symptomatic multiple myeloma were all evident in this case; namely osteolytic lesions, monoclonal gammopathy in the serum with excretion of monoclonal proteins in the urine, neoplastic plasma cells in the bone marrow and associated renal failure and anaemia. In addition, similar to the common pattern of this disease in domestic felids, at least three extramedullary tumours were found and several organs were infiltrated by neoplastic plasma cells. The cytoplasm of approximately 50%of the neoplastic round cells, including a few giant myeloma cells, stained weakly to strongly using immunohistochemical stains for B-lymphocytes (CD79a). The normal haematological parameters and lack of any osteolytic lesions in the lion at the time of the first evaluation suggest that the primary neoplastic cells could have originated from one of the extramedullary tumour sites. Only two cases of multiple myeloma have previously been reported in captive wild felids. To the authors’ knowledge, there are no case reports of multiple myeloma in lions.
Facilitators and Barriers to Living with Psychosis: An Exploratory Collaborative Study of the Perspectives of Mental Health Service Users
Authors: Makdisi Lana , Blank Alison , Bryant Wendy , Andrews Christine , Franco Lucia , Parsonage Jackie 
Published: September 2013

Introduction: The purpose of this research was to deepen understanding of what is helpful to those who have experienced psychosis, in order to facilitate best practice within mental health services. Psychosis presents challenges for people on an everyday basis, yet strategies can be developed to facilitate living with psychosis. Investigating the service user's perspective is crucial for informing recovery oriented occupational therapy practice. Method: Initiated and designed by a service user research group, this research was exploratory and, primarily, participatory. Data were gathered from two focus groups, involving 13 people with experience of psychosis, facilitated by service user researchers and an MSc student. Data analysis was systematic and based on grounded theory principles Findings: Participants shared experiences and thoughts about their everyday lives. Data analysis revealed six elements of the self: the social self; the occupational self; the integrated self; the unsupported self; the stigmatised self and the isolated self. The importance of balancing these six facets of the self is theorised as being essential to successfully managing the experience of living with psychosis. Conclusion: This emergent theory could underpin occupation-focused approaches to living with psychosis, with interventions aimed at enabling service users to balance the experience of psychosis with satisfying and contributing lives or recovery.
Pulmonary Venous Doppler Flow Profile before and after Surgical Closure of Atrial Septal Defect in Children
Authors: Gadhinglajkar Shrinivas , Sreedhar Rupa , Menon Sabarinath , Omprakash S 
Published: September 2013

ABSTRACT

Objectives
A secundum atrial septal defect is associated with a characteristic pattern of continuous antegrade wave on a pulmonary venous Doppler flow profile. It is replaced with a regular S and D wave after the closure of defect. Although, a few published reports have described these features in adults, there are not enough studies in pediatric patients under anesthesia.

Setting
A tertiary referral center.

Participants
A total of 12 children with uncomplicated secundum atrial septal defect participated in the evaluation process.

Interventions
After anesthesia induction, three of them were excluded from detailed pulmonary venous study as they did not satisfy selection criteria. In remaining nine children, the intraoperative pulmonary venous Doppler changes were assessed before and after the defect closure, manually tracing the pulmonary venous waveforms.

Measurements and main results
The antegrade wave was observed in 9/9 patients before surgery that characteristically lacked distinct systolic and diastolic waves, although in seven patients, a larger systolic peak and a smaller diastolic peak were identified.
Normal S and D waves were seen after termination of cardiopulmonary bypass with S/D ratio >1 in all cases. The maximum velocity of atrial retrograde wave increased and heart rate decreased significantly after surgery.

Conclusion
The continuous antegrade wave is a consistent pulmonary venous Doppler feature of an uncomplicated secundum ASD in anesthetized children. The Doppler pattern is normalized immediately after termination of cardiopulmonary bypass.

How to cite this article
Gadhinglajkar S, Sreedhar R, Menon S, Omprakash S. Pulmonary Venous Doppler Flow Profile before and after Surgical Closure of Atrial Septal Defect in Children. J Perioper Echocardiogr 2013;1(2):42-47.
A Case of Delayed Cardiac Tamponade: Highlighting the Importance of Transthoracic Echocardiography Training for Anesthesiologists
Authors: Peretich Kelly T , Saba Samir , Byrd Heather 
Published: September 2013

ABSTRACT
This echo report describes a patient who developed cardiac temponade in the post-anesthesia care unit after laser lead extraction at electrophysiology laboratory. Diagnosis was readily established by transthoracic echocardiography and this lead to good outcome. Transthoracic ultrasound helps in preoperative evaluation of non-cardiac surgical patients and also postoperative care of hemodynamically unstable patients. This describes the importance of training and competence in transthoracic ultrasound for anesthesiologists.

How to cite this article
Peretich KT, Liu JC, Saba S, Byrd H, Subramaniam K. A Case of Delayed Cardiac Tamponade: Highlighting the Importance of Transthoracic Echocardiography Training for Anesthesiologists. J Perioper Echocardiogr 2013; 1(2):69-71.
Utility of 4-Chloro-7-Nitrobenzofurazan (NBD-Cl) for the Spectrophotometric and Spectrofluorometric Determination of Several Antihistamine and Antihypertensive Drugs
Authors: Abd El-Hay Soad S , Colyer Christa L , Hassan Wafaa S , Shalaby Abdalla 
Published: September 2013

Abstract
New, sensitive, and selective spectrophotometric and spectrofluorometric methods have been developed for determination of clemastine hydrogen fumarate (Clem), loratadine (Lor), losartan potassium (Los), and ramipril (Ram) in both pure form and pharmaceutical formulations using 4-chloro-7-nitrobenzofurazan (NBD-Cl), which is a highly sensitive chromogenic and fluorogenic reagent. The relation between absorbance at 470, 467, 471, and 469 nm and the concentration was linear over the ranges 5–35, 10–100, 10–90, and 10–120 μg/mL for Clem, Lor, Los, and Ram, respectively. The complexation products were also measured spectrofluorometrically at the emission wavelength 535 nm for Clem, Lor, and Ram and at 538 nm for Los with excitation at 477 and 452 nm for Clem and Lor, respectively, and 460 nm for both Los and Ram. The fluorescence intensity was directly proportional to the drug concentration over the ranges 0.05–0.5, 5–20, 1–6, and 2–15 μg/mL for Clem, Lor, Los, and Ram, respectively. The methods were successfully applied for the determination of the studied drugs in pharmaceutical dosage forms with excellent recovery.
Faster Extraction of Heavy Metals from Soils Using Vacuum and Ultrasonic Energy
Authors: Pontes Fernanda V M , Carneiro Manuel C , de Souza Evelyn da M F , da Silva Lílian I D , Monteiro Maria Inês C , Neto Arnaldo A 
Published: September 2013

Abstract
A fast vacuum- and ultrasound-assisted acid extraction of Co, Cu, Fe, Mn, Pb, and Zn from soils using a homemade system has been investigated. Preliminarily, a full factorial design with two levels and three variables (extracting agent, extraction temperature, and sonication time) was applied to optimize the extraction conditions (without vacuum) for some heavy metals (Cu, Mn, Pb, and Zn). The best results were obtained with a 3:1 HCl extraction solution, temperature of 80°C, and time of 2 h. As this sonication time was too long, a vacuum pump was used to produce air bubbles in order to increase the contact between the sample and the extracting agent and to prevent the sample sedimentation. This improvement drastically reduced the sonication time to 2 min. Under these conditions, Co, Cu, Mn, and Zn were totally extracted (recoveries of 86–99%), while recoveries of 73–76 and 74% were obtained for Fe and Pb, respectively. The LOD values using flame atomic absorption spectrometry for determination of Co, Cu, Fe, Mn, Pb, and Zn were 3.2, 7.5, 37.5, 7.5, 22.5, and 3.8 μg/g, respectively. The RSDs were lower than 11% (n = 3).
Validated Stability-Indicating Capillary Electrophoresis Method for the Separation and Determination of a Fixed-Dose Combination of Carvedilol and Hydrochlorothiazide in Tablets
Authors: Alzoman Nourah Z , Sultan Maha A , Maher Hadir M , AlShehri Mona M , Olah Ileana V 
Published: September 2013

Abstract
A novel, fast, sensitive, and specific capillary electrophoresis (CE) technique coupled to a diode array detector has been developed for the separation and simultaneous determination of carvedilol (CRV) and hydrochlorothiazide (HCT) in two combination formulations. The proposed method utilized a fused silica capillary (55 cm × 75 μm id) and the background electrolyte solution phosphate buffer (12.5 mM, pH 7.4)–methanol (95 + 5, v/v). The separation was achieved at 30 kV applied voltage and 24°C. Atorvastatin (80 μg/mL) was chosen as the internal standard. The described method was linear over the range of 1–200 and 0.2–150 μg/mL for CRV and HCT, respectively. Intraday and interday RSD (n = 6) was ≤1.4%. The LOD values of CRV and HCT were 0.26 and 0.07 μg/mL, respectively. The validated CE method was successfully applied to the analysis of two commercial tablet dosage forms. Forced degradation studies were performed on bulk samples of the two drugs using thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were analyzed by the proposed method. Degradation products produced as a result of stress studies did not interfere with the determination of CRV and HCT; the assay could, therefore, be considered stability-indicating.
A Geographical Discrimination of Shanxi Extra Aged Vinegars Using Polyalcohols as the Discriminators
Authors: Luo Meizhong , Zheng Yanjie , Xiong Cen , Li Bifang , Chen Sujuan , Bai Wenliang , Zeng Yongting , Li Yongle , Zhang Xieguang 
Published: September 2013

Abstract
A discrimination method based on polyalcohol determination was developed for authenticity of protected geographical indication (PGI) vinegars—Shanxi extra aged vinegar (SVs) in China. Six polyalcohols in vinegars including erythritol, arabitol, xylitol, inositol, mannitol, and sorbitol were selected as the PGI discriminators. GC/MS was used to analyze the polyalcohols in the SVs, Zhenjiang vinegars (ZVs), Kazuo aged vinegars (KVs), and other non-geographical indication protected vinegars (NVs). SVs can be distinguished from KVs by the chemical markers mannitol and sorbitol, although the production processes for both types of vinegars are similar. Principal component analysis (PCA) was used to distinguish SVs from ZVs and NVs. The differences among the three kinds of vinegars shown by PCA results may be due to the higher erythritol content in SVs, and the inositol and mannitol in ZVs. This study also found that the amount of polyalcohols in Chinese vinegars increases with the acidity value only, regardless of the aging time. The overall results indicated that the polyalcohols can be practicable discriminators for SV discrimination.
Rapid Method for the Simultaneous Determination of Flavonol Aglycones in Food Using u-HPLC Coupled with Heating Block Acidic Hydrolysis
Authors: Shim You-Shin , Kim Seunghee , Seo Dongwon , Ito Masahito , Nakagawa Hiroaki , Park Hyun-Jin , Ha Jaeho 
Published: September 2013

Abstract
A rapid method for the simultaneous determination of flavonol aglycones in food using ultra-high-performance LC (u-HPLC) coupled with a heating-block acidic hydrolysis method was validated in terms of precision, accuracy, and linearity. The u-HPLC separation was performed on an RP C18 column (particle size 2 μm id, 2 mm, length 100 mm) with a photodiode array detector. The LOD and LOQ of the u-HPLC analyses were 0.15 and 0.47 mg/kg for myricetin, 0.09 and 0.28 mg/kg for quercetin, 0.16 and 0.49 mg/kg for kaempferol, and 0.08 and 0.25 mg/kg for isorhamnetin. The intraday and interday precisions of the individual flavonol aglycones were less than 9.31%. All calibration curves exhibited good linearity (r2 = 0.99) within the tested ranges. Total run time of u-HPLC was 13 min. The rapid u-HPLC method presented herein significantly improved the speed, sensitivity, and resolution of the analyses of myricetin, quercetin, kaempferol, and isorhamnetin in food.
Interlaboratory Validation Study of an Event-Specific Real-time Polymerase Chain Reaction Detection Method for Genetically Modified 55-1 Papaya
Authors: Noguchi Akio , Nakamura Kosuke , Sakata Kozue , Kobayashi Tomoko , Akiyama Hiroshi , Kondo Kazunari , Teshima Reiko , Ohmori Kiyomi , Kasahara Masaki , Takabatake Reona , Kitta Kazumi 
Published: September 2013

Abstract
Genetically modified (GM) papaya line 55-1 (55-1) is resistant to papaya ringspot virus infection, and is commercially available in several countries. A specific detection method for 55-1 is required for mandatory labeling regulations. An event-specific real-time PCR method was developed by our laboratory. To validate the method, interlaboratory validation of event-specific qualitative real-time PCR analysis for 55-1 was performed in collaboration with 12 laboratories. DNA extraction and real-time PCR reaction methods were evaluated using 12 blind samples: six non-GM papayas and six GM papayas in each laboratory. Genomic DNA was highly purified from all papayas using an ion-exchange column, and the resulting DNA sample was analyzed using real-time PCR. Papaya endogenous reference gene chymopapain (CHY) and the event-specific 55-1 targeted sequence were detected in GM papayas whereas CHY alone was detected in non-GM papayas in all laboratories. The cycle threshold values of CHY and the 55-1 targeted sequence showed high repeatability (RSDr 0.6–0.8%) and reproducibility (RSDR 2.2–3.6%). This study demonstrates that the 55-1 real-time PCR detection method is a useful and reliable method to monitor 55-1 papaya in foods.
Ultra-High Performance Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry Determination of 151 Pesticides in Soybeans and Pulses
Authors: Wang Jian , Cheung Wendy , Chow Willis 
Published: September 2013

Abstract
This paper presents the application of ultra-high performance LC (UHPLC) and MS for the determination of 151 pesticides in soybeans and pulses. A core-shell particle (2.6 μm particle size) column and a fully porous sub-2 μm (1.7 μm particle size) column showed comparable performance in chromatographic resolution and separation, increasing selectivity, and reducing analysis time. UHPLC was coupled with either a triple quadrupole mass analyzer (MS/MS) or a quadrupole Orbitrap (namely Orbital trap) mass spectrometer (Q-Orbitrap MS), which possesses fast data acquisition capability. Both configurations yielded analytical run times of ≤14 min. Soybean and pulse samples were analyzed and quantitated for pesticide residues using the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) procedure, UHPLC/electrospray ionization (ESI)-MS/MS, and matrix-matched standard calibration curves (in an analytical range of 5–500 μg/kg) with isotopically-labeled standards or a chemical analog as internal standards. The method performance parameters that included overall recovery, intermediate precision, and measurement uncertainty were evaluated according to a nested design experiment. Approximately 89% of the pesticides studied had recoveries between 81 and 110%; 95%, had intermediate precision ≤20%; and 93% showed measurement uncertainty ≤40%. From a pilot study of 100 samples, eight tested positive by UHPLC/ESI-MS/MS for carbendazim, methomyl, or imidacloprid. These pesticides were further confirmed using UHPLC/ESI-Q-Orbitrap MS based on accurate mass measurement with mass error ≤5 ppm.
Determination of Arsenic, Cadmium, Mercury, and Lead in Foods by Pressure Digestion and Inductively Coupled Plasma/Mass Spectrometry: First Action 2013.06
Authors: Julshamn Kaare , Maage Amund , Norli Hilde Skaar , Grobecker Karl H , Jorhem Lars , Fecher Peter , Dowell Dawn 
Published: September 2013

Abstract
The method for the determination of As, Cd, Hg, and Pb in foods by pressure digestion and inductively coupled plasma (ICP)/MS, previously published in J.AOAC Int. 90, 844–856 (2007), was approved as First Action 2013.06 on April 9, 2013 by the Method-Centric Committee for Elemental Contaminants in Food. Digestion occurs using nitric acid in a closed vessel with elevated temperature and pressure by conventional or microwave-assisted heating. Determination occurs using ICP/MS. The elemental concentration ranges for As were 0.06–21.4, for Cd 0.03–28.3, for Hg 0.04–0.6, and for Pb 0.01–2.4 in mg/kg dry matter. The repeatability RSD (RSDr) ranged from 3.8 to 24% for As, 2.6 to 6.9% for Cd, 4.8 to 8.3% for Hg, and 2.9 to 27% for Pb. Reproducibility RSD (RSDR) ranged from 9.0 to 28% for As, 2.8 to 18% for Cd, 9.9 to 24% for Hg, and 8 to 50% for Pb.
“A Future in the Past”? Tourism Development, Outport Archaeology, and the Politics of Deindustrialization in Newfoundland and Labrador in the 1990s
Authors: Overton James 
Published: September 2013

The fishing industry crisis of the 1990s saw the already precarious economic base of the many towns and small communities further eroded in Newfoundland and Labrador. The situation was made worse by both federal and provincial pursuit of programs of economic liberalization that sought to limit the role of the state in economic and social affairs. As the effects of the crisis were felt, and established state supports were weakened, tourism was embraced by a growing body of local development and heritage organizations as a way of restoring the shattered economic base of many communities. Limited, short-term funding for some tourism-related projects was provided mostly from government programs, largely as a means of politically managing the structural adjustment that was being pursued. This paper examines the role of the state policy in deindustrialization. After discussing the crisis in Newfoundland and Labrador and the promotion of community development in response to that crisis, some of the problems associated with tourism development and "outport archaeologyn are outlined. Focusing on sustainability and survival, an assessment is made of the role of tourism in dealing with crisis in the once-fishing-dependent communities of Newfoundland and Labrador.
Eden Smith and the Canadian Domestic Revival
Authors: Adams Annmarie 
Published: September 2013

The designer of more than 2500 detached houses in late nineteenth-century and early twentieth-century Toronto, Eden Smith has been hailed as the author of a distinctly Canadian style of domestic architecture. Yet his self-promotion and the reception of his work in both the professional and popular presses of the time emphasize the Englishness of his houses. This paper considers the domestic architecture of Eden Smith as an index of attitudes held by Toronto's upper middle class toward Britain in the early twentieth century. What did the image of an "English house" represent in Edwardian Toronto? Why were these particular qualities attractive to Toronto's landed gentry? Eden Smith's architecture was both distinct and derivative. The language of the elevations was unmistakably British, while the plan of his houses was something completely new. Smith's popularity and his influence on subsequent generations of Canadian house-architects speak eloquently of the willingness of Toronto's middle class to try new things, but only clothed in the auspices of a British past.
La Bildung dans quatre nouvelles du Sort de Fille de Michael Delisle*
Authors: Mottet Philippe 
Published: September 2013

Plusieurs oeuvres narratives de Michael Delisle abordent le thème de l’initiation dans le cadre de la banlieue de la rive sud de Montréal des années 1960 et 1970. Dans les nouvelles d’Helen avec un secret et du Sort de Fille, les rencontres que font les protagonistes (généralement adolescents) constituent autant d’événements initiatiques vécus dans l’adversité. Dans Le sort de Fille, ces initiations, malgré la logique du recueil de textes indépendants qui est la sienne, composent une véritable Bildung, donc un ensemble coordonné d’initiations, malgré l’apparente diversité des personnages qui en font l’objet. C’est à définir l’unité et la syntaxe de cette Bildung dans quatre des sept nouvelles du Sort de Fille que s’attèle l’auteur de cet article.
De la judéité souterraine au texte-crypte dans Barney’s version de Mordecai Richler
Authors: Constant Marie-Hélène 
Published: September 2013

Le dernier roman de Mordecai Richler, Barney’s Version (1997), s’il propose sous la forme des mémoires un récit autobiographique du personnage de Barney Panofsky, déploie un sous-texte rempli de références culturelles et mémorielles qui en appelle à une communauté de lecteurs élus par une même connaissance des signes textuels de la judéité. Cet article tente d’abord de montrer comment est (ré)activé ce réseau dans la construction d’une bibliothèque imaginaire érigée en lieu de mémoire permettant le legs patrilinéaire. Sur ces bases, il dégage ensuite en quoi l’anglais « yiddishifié » de Richler est un lieu de sédimentation de l’identitaire judaïque, et opère comme une modalité du rite, c’est-à-dire dans un double mouvement d’ouverture à l’élection d’une communauté et de repli sur le secret — moyen de préserver l’accès aux signes aux initiés, à la manière du schibboleth.
Constitutionnalité de dispositions conférant un statut, des privilèges et des droits à une langue minoritaire : le cas singulier du Nunavut et de sa Loi sur la protection de la langue inuit
Authors: Robinson Julie , Power Mark C. 
Published: September 2013

La Loi sur la protection de la langue inuit (LPLI) est une loi récente du Nunavut. Unique en son genre au Canada, elle est plus ambitieuse encore que la Charte de la langue française du Québec. Loi controversée, certains se demandent si le législateur n’aurait pas outrepassé ses pouvoirs en adoptant certaines de ses dispositions. En effet, l’article 3 de la LPLI prétend obliger les ministères, organismes ou institutions du gouvernement fédéral opérant au Nunavut à fournir leurs services destinés au public et à afficher leurs panneaux en langue inuit, alors même que ces organisations agissent à l’intérieur d’un champ de compétence fédérale. Les articles 29, 30 et 34 de la LPLI rendent obligatoire la préparation d’un plan d’action pour la langue inuit précisant la manière dont une organisation entend respecter la loi. Ce plan doit être approuvé par le commissaire aux langues, qui dispose d’un important pouvoir d’enquête relativement au respect de la loi. Au premier abord, ces dispositions semblent contredire la règle aujourd’hui acceptée selon laquelle un ordre de gouvernement peut légiférer en matière de langue dans la mesure où il le fait de manière accessoire à un champ de compétence qui lui est propre. Cette norme tire sa force de certaines particularités de la Loi constitutionnelle de 1867. Toutefois, après analyse, il appert que ce cadre conceptuel ne s’applique pas au Nunavut. Ce dernier détient bel et bien le pouvoir d’imposer sur son territoire l’utilisation de la langue inuit aux ministères, organismes et institutions du gouvernement fédéral.