bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recombinant Parainfluenza Virus 5 Expressing Hemagglutinin of Influenza A Virus H5N1 Protected Mice against Lethal Highly Pathogenic Avian Influenza Virus H5N1 Challenge
Authors: Li Zhuo , Mooney Alaina J. , Gabbard Jon D. , Gao Xiudan , Xu Pei , Place Ryan J. , Hogan Robert J. , Tompkins S. Mark , He Biao 
Published: October 2012

ABSTRACTA safe and effective vaccine is the best way to prevent large-scale highly pathogenic avian influenza virus (HPAI) H5N1 outbreaks in the human population. The current FDA-approved H5N1 vaccine has serious limitations. A more efficacious H5N1 vaccine is urgently needed. Parainfluenza virus 5 (PIV5), a paramyxovirus, is not known to cause any illness in humans. PIV5 is an attractive vaccine vector. In our studies, a single dose of a live recombinant PIV5 expressing a hemagglutinin (HA) gene of H5N1 (rPIV5-H5) from the H5N1 subtype provided sterilizing immunity against lethal doses of HPAI H5N1 infection in mice. Furthermore, we have examined the effect of insertion of H5N1 HA at different locations within the PIV5 genome on the efficacy of a PIV5-based vaccine. Interestingly, insertion of H5N1 HA between the leader sequence, thede factopromoter of PIV5, and the first viral gene, nucleoprotein (NP), did not lead to a viable virus. Insertion of H5N1 HA between NP and the next gene, V/phosphorprotein (V/P), led to a virus that was defective in growth. We have found that insertion of H5N1 HA at the junction between the small hydrophobic (SH) gene and the hemagglutinin-neuraminidase (HN) gene gave the best immunity against HPAI H5N1 challenge: a dose as low as 1,000 PFU was sufficient to protect against lethal HPAI H5N1 challenge in mice. The work suggests that recombinant PIV5 expressing H5N1 HA has great potential as an HPAI H5N1 vaccine.
Conditional Diagnosability of k-Ary n-Cubes under the PMC Model
Authors: Chang Nai-Wen , Lin Tzu-Yin , Hsieh Sun-Yuan 
Published: October 2012

Processor fault diagnosis plays an important role in measuring the reliability of multiprocessor systems and the diagnosis of many well-known interconnection networks. The conditional diagnosability, which is more general than the classical diagnosability, is to measure the diagnosability of a multiprocessor system under the assumption that all of the neighbors of any node in the system cannot fail at the same time. This study shows that the conditional diagnosability for
k
-ary
n
-cubes under the PMC model is 8
n
− 7 for
k
≥ 4 and
n
≥ 4.
Migration-Resistant Policies for Probe-Wear Leveling in MEMS Storage Devices
Authors: Khatib Mohammed G. 
Published: October 2012

Probes (read/write heads) in a MEMS storage device are susceptible to wear. We study probe wear, and analyze the causes of uneven wear. We show that under real-world workloads some probes can wear one order of magnitude faster than others. This premature expiry has severe consequences for reliability, timing performance, energy efficiency, and lifetime. Wear leveling precludes premature expiry and is thus necessary. We discuss the fundamental differences between probe wear in MEMS storage and medium wear in Flash, calling for a different treatment.
We devise three policies to level probe wear. The policies provide a spectrum between best lifetime and least influence on the response time and energy efficiency of a MEMS storage device. We make the case that data migration can be prevented by augmenting the policies with a simple rule. We study the influence of the data layout configuration on the leveling performance of the policies.
Research challenges in measuring data for population health to enable predictive modeling for improving healthcare
Authors: Schatz Bruce , Marsh Clay , Gustafson David , Patrick Kevin , Krishnan Jerry , Kumar Santosh , Contractor Noshir 
Published: October 2012

At the core of the healthcare crisis is a fundamental lack of actionable data, needed to stratify individuals within populations, to predict which persons have which outcomes. A new health system with better health management will require better health measurement, to improve cost and quality. It is now possible to use new technologies to provide the rich datasets necessary for adequate health measurement, which enables new information systems for new health systems.

This report is a summary of a workshop on
Measuring Data for Population Health
, sponsored by the NSF SmartHealth program with assistance from the NIH mHealth initiative, held on January 12--13, 2012 in Washington DC. There were 42 attendees, including invited researchers from academia, government and industry, plus program officers from NSF and NIH.

The workshop had background talks by leaders in health systems and information systems, followed by breakout discussions on future challenges and opportunities in measuring and managing population health. This report describes the observations on what problems of health systems should be addressed and what solutions of information systems should be developed. The recommendations cover how new information technologies can enable new health systems, with support from future initiatives of federal programs.
The workshop and its report identify research challenges that utilize new computing and information technologies to enable better measurement and management for practical healthcare. The measurement technologies focus on deeper monitoring of broader populations. The management technologies focus on utilizing new personal health records to provide personalized treatment guidelines, specialized for each population cohort. This would enable predictive modeling for health systems to support viable healthcare at acceptable cost and quality.
A workshop website contains background and discussion notes: https://wiki.engr.illinois.edu/display/hiworkshop/NSF+Workshop+Population+Health
Survival After Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy
Authors: Sorajja Paul , Ommen Steve R. , Holmes David R. , Dearani Joseph A. , Rihal Charanjit S. , Gersh Bernard J. , Lennon Ryan J. , Nishimura Rick A. 
Published: October 2012

Background—
The clinical efficacy of alcohol septal ablation for obstructive hypertrophic cardiomyopathy (HCM) has been demonstrated, but the long-term effects of the procedure remain uncertain. This study examined the survival of patients after septal ablation performed in a tertiary HCM referral center.

Methods and Results—

We examined 177 patients (mean age, 64 years; 68% women) who underwent septal ablation at our institution. Over a follow-up of 5.7 years, survival free of all mortality was no different than the expected survival for a comparable general population, and similar to that of age- and sex-matched patients who underwent isolated surgical myectomy (8-year survival estimate, 79% versus 79%;
P
=0.64). For the end point of documented sudden cardiac death or unknown cause of death, the incidence per 100 person-year follow-up was 1.31 (95% confidence interval, 0.60–2.38). Residual left ventricular outflow tract gradient after ablation was an independent predictor of long-term survival free of any death.

Conclusions—
In this nonrandomized study of carefully selected patients undergoing septal ablation by experienced operators in a tertiary referral HCM center, long-term survival was favorable and similar to that of an age- and sex-matched general population, and to patients undergoing surgical myectomy, as well, without an increased risk of sudden cardiac death.
Is a Transition to Semipermanent Drought Conditions Imminent in the U.S. Great Plains?
Authors: Hoerling Martin P. , Eischeid Jon K. , Quan Xiao-Wei , Diaz Henry F. , Webb Robert S. , Dole Randall M. , Easterling David R. 
Published: October 2012

Abstract
How Great Plains climate will respond under global warming continues to be a key unresolved question. There has been, for instance, considerable speculation that the Great Plains is embarking upon a period of increasing drought frequency and intensity that will lead to a semipermanent Dust Bowl in the coming decades. This view draws on a single line of inference of how climate change may affect surface water balance based on sensitivity of the Palmer drought severity index (PDSI). A different view foresees a more modest climate change impact on Great Plains surface moisture balances. This draws on direct lines of analysis using land surface models to predict runoff and soil moisture, the results of which do not reveal an ominous fate for the Great Plains. The authors’ study presents a parallel diagnosis of projected changes in drought as inferred from PDSI and soil moisture indicators in order to understand causes for such a disparity and to shed light on the uncertainties. PDSI is shown to be an excellent proxy indicator for Great Plains soil moisture in the twentieth century; however, its suitability breaks down in the twenty-first century, with the PDSI severely overstating surface water imbalances and implied agricultural stresses. Several lines of evidence and physical considerations indicate that simplifying assumptions regarding temperature effects on water balances, especially concerning evapotranspiration in Palmer’s formulation, compromise its suitability as drought indicator in a warming climate. The authors conclude that projections of acute and chronic PDSI decline in the twenty-first century are likely an exaggerated indicator for future Great Plains drought severity.
The Landfall and Inland Penetration of a Flood-Producing Atmospheric River in Arizona. Part I: Observed Synoptic-Scale, Orographic, and Hydrometeorological Characteristics
Authors: Neiman Paul J. , Ralph F. Martin , Moore Benjamin J. , Abel Mimi R. , Mahoney Kelly M. , Cordeira Jason M. , Dettinger Michael D. 
Published: October 2012

AbstractAtmospheric rivers (ARs) are a dominant mechanism for generating intense wintertime precipitation along the U.S. West Coast. While studies over the past 10 years have explored the impact of ARs in, and west of, California’s Sierra Nevada and the Pacific Northwest’s Cascade Mountains, their influence on the weather across the intermountain west remains an open question. This study utilizes gridded atmospheric datasets, satellite imagery, rawinsonde soundings, a 449-MHz wind profiler and global positioning system (GPS) receiver, and operational hydrometeorological observing networks to explore the dynamics and inland impacts of a landfalling, flood-producing AR across Arizona in January 2010. Plan-view, cross-section, and back-trajectory analyses quantify the synoptic and mesoscale forcing that led to widespread precipitation across the state. The analyses show that a strong AR formed in the lower midlatitudes over the northeastern Pacific Ocean via frontogenetic processes and sea surface latent-heat fluxes but without tapping into the adjacent tropical water vapor reservoir to the south. The wind profiler, GPS, and rawinsonde observations document strong orographic forcing in a moist neutral environment within the AR that led to extreme, orographically enhanced precipitation. The AR was oriented nearly orthogonal to the Mogollon Rim, a major escarpment crossing much of central Arizona, and was positioned between the high mountain ranges of northern Mexico. High melting levels during the heaviest precipitation contributed to region-wide flooding, while the high-altitude snowpack increased substantially. The characteristics of the AR that impacted Arizona in January 2010, and the resulting heavy orographic precipitation, are comparable to those of landfalling ARs and their impacts along the west coasts of midlatitude continents.
Quantifying the Nonconservative Production of Conservative Temperature, Potential Temperature, and Entropy
Authors: Graham Felicity S. , McDougall Trevor J. 
Published: October 2012

Abstract
The evolution equation of potential temperature has to date been treated as an approximation to the oceanic version of the first law of thermodynamics. That is, oceanographers have regarded the advection and diffusion of potential temperature as the advection and diffusion of “heat.” However, the nonconservative source terms that arise in the evolution equation for potential temperature are estimated to be two orders of magnitude larger than the corresponding source terms for Conservative Temperature. In this paper the nonconservative source terms of potential temperature, Conservative Temperature, and entropy are derived for a stratified turbulent fluid, then quantified using the output of a coarse-resolution ocean model and compared to the rate of dissipation of mechanical energy, epsilon. It is shown that the error incurred in ocean models by assuming that Conservative Temperature is 100% conservative is approximately 120 times smaller than the corresponding error for potential temperature and at least 1200 times smaller than the corresponding error for entropy. Furthermore, the error in assuming that Conservative Temperature is 100% conservative is approximately 6 times smaller than the error in ignoring epsilon. Hence Conservative Temperature can be quite accurately regarded as a conservative variable and can be treated as being proportional to the “heat content” per unit mass of seawater, and therefore it should now be used in place of potential temperature in physical oceanography, including as the prognostic temperature variable in ocean models.
What is needed to deliver collaborative care to address comorbidity more effectively for adults with a severe mental illness?
Authors: Lee Stuart J , Crowther Elizabeth , Keating Charlotte , Kulkarni Jayashri 
Published: October 2012

Objective: Innovative models of care for people with a severe mental illness have been developed across Australia to more effectively address comorbidity and disability by enhancing the collaboration between clinical and non-clinical services. In particular, this review paper focuses on collaboration that has occurred to address comorbidities affecting the following domains: homelessness; substance addiction; physical ill-health; unemployment; and forensic issues. Method: The identification of relevant collaborative care models was facilitated by carrying out a review of the published peer-reviewed literature and policy or other published reports available on the Internet. Contact was also made with representatives of the mental health branches of each Australian state and territory health department to assist in identifying examples of innovative collaborative care models established within their jurisdiction. Results: A number of nationally implemented and local examples of collaborative care models were identified that have successfully delivered enhanced integration of care between clinical and non-clinical services. Several key principles for effective collaboration were also identified. Governmental and organisational promotion of and incentives for cross-sector collaboration is needed along with education for staff about comorbidity and the capacity of cross-sector agencies to work in collaboration to support shared clients. Enhanced communication has been achieved through mechanisms such as the co-location of staff from different agencies to enhance sharing of expertise and interagency continuity of care, shared treatment plans and client records, and shared case review meetings. Promoting a ‘housing first approach’ with cross-sector services collaborating to stabilise housing as the basis for sustained clinical engagement has also been successful. Conclusions: Cross-sector collaboration is achievable and can result in significant benefits for mental health consumers and staff of collaborating services. Expanding the availability of collaborative care across Australia is therefore a priority for achieving a more holistic, socially inclusive, and effective mental health care system.
A field study of a wastewater source heat pump for domestic hot water heating
Authors: Chao Shen , Yiqiang Jiang , Yang Yao , Shiming Deng , Xinlei Wang 
Published: October 2012

An experimental heat pump utilizing wastewater discharged from the common bathroom in a SPA center as a heat source was built. In this article, the field measured operating performance of the wastewater source heat pump is reported. An analysis based on the collected field data under various operating conditions is included. It was shown that the temperature of wastewater greatly affected the evaporating temperature and the coefficient of performance of the wastewater source heat pump. Circulating wastewater from the bottom to the top of the wastewater storage tank could weaken even out the vertical wastewater temperature distribution inside the wastewater storage tank and improve the coefficient of performance and compressor suction pressure of the wastewater source heat pump accordingly. The daily averaged coefficient of performance of the wastewater source heat pump was monitored for over an entire month. It was shown that the measured coefficient of performance gradually reduced, suggesting the need for regular cleaning of the heat exchangers used in a wastewater source heat pump system. In addition, the recorded maximum transporting capacity of the wastewater pipe reduced by 16.9% over the 1 month operation and by 20.1% after ∼5 months due to the bio-fouling build-up. Finally, an analysis comparing the economics of operating a wastewater source heat pump system with that of operating conventional water heating systems is presented. Practical application: The use of heat pump to recover heat from wastewater is significant to energy conservation and environmental protection. A number of researches and projects on wastewater source heat pumps using urban sewage or treated sewage as a heat source have been carried out. However, field measured results on a heat pump, which recovered heat from waste bath water, was not previously reported. As the quality of waste bath water was different from that of sewage in terms of temperature, amount, and the degree of cleanliness, the experiences on designing and operating urban sewage source heat pumps previously obtained could not be used as a full reference for designing a waste bath water source heat pump. In this article, field experiment work of designing and operating a heat pump which used waste bath water as a heat source for hot water heating is presented, and the results can be used as a key reference for designing and operating waste bath water source heat pump systems in the future.
Bayesian Probability and Statistics in Management Research
Authors: Zyphur Michael J. , Oswald Frederick L. 
Published: October 2012

Special Issue Purpose This special issue is focused on how a Bayesian approach to estimation, inference, and reasoning in organizational research might supplement—and in some cases supplant—traditional frequentist approaches. Bayesian methods are well suited to address the increasingly complex phenomena and problems faced by 21st-century researchers and organizations, where very complex data abound and the validity of knowledge and methods are often seen as contextually driven and constructed. Traditional modeling techniques and a frequentist view of probability and method are challenged by this new reality.
GFAP-Positive Neoplastic Astrocytes in Spontaneous Oligodendrogliomas and Mixed Gliomas of Rats
Authors: Nagatani Mariko , Yamakawa Seiki , Saito Tsubasa , Ando Ryo , Hoshiya Toru , Tamura Kazutoshi , Uchida Kazuyuki 
Published: October 2012

It is generally said that neoplastic cells are immunohistochemically negative for glial fibrillary acidic protein (GFAP) in rat spontaneous astrocytomas, and there are no reports describing the existence of GFAP-positive neoplastic astrocytes in rat spontaneous oligodendrogliomas and mixed gliomas which contain neoplastic astrocytes. In the present study, to clarify whether GFAP-positive neoplastic astrocytes exist in rat spontaneous oligodendrogliomas and mixed gliomas or not, immunohistochemical examination was performed on spontaneous oligodendrogliomas (26 cases) and mixed gliomas (5 cases) collected from the carcinogenicity studies and short-term toxicity studies. The neoplastic cells that constitute oligodendrogliomas and mixed gliomas were morphologically classified into five types: round A, round B, round C, spindle, and bizarre. The cells of round A, B, and C types were thought to be neoplastic oligodendrocytes because of their positive immunostainability for Olig2. The origin of bizarre cells was obscure because they were negative for Olig2, GFAP, and nestin. The spindle cells were considered to be neoplastic astrocytes, because some of them were positive for GFAP or nestin, and GFAP-positive spindle cells could be morphologically distinguished from reactive astrocytes. In conclusion, the present study clarified for the first time that GFAP-positive neoplastic astrocytes exist in rat spontaneous gliomas.
Extracorporeal Shockwave Therapy for Treatment of Delayed Tendon-Bone Insertion Healing in a Rabbit Model
Authors: Chow Dick Ho Kiu , Suen Pui Kit , Fu Lai Hong , Cheung Wing Hoi , Leung Kwok Sui , Wong Margaret Wan Nar , Qin Ling 
Published: October 2012

Background: Tendon–bone insertion (TBI) consists of both hard and soft tissues. TBI injury with delayed repair is not uncommon. High-dose extracorporeal shockwave (ESW) is effective for treating nonunion fracture, whereas low-dose ESW is used for tendinopathy therapy. The dosing effect of ESW on delayed TBI healing is lacking. Hypothesis: Low-dose ESW might have a healing enhancement effect comparable to that of high-dose ESW in treating delayed TBI healing. Study Design: Controlled laboratory study. Methods: Partial patellectomy was adopted to create a delayed TBI healing model by shielding the healing interface between tendon and bone. Ninety-six female New Zealand White rabbits with unilateral delayed TBI healing at the knee joint were divided into 3 groups: controls, low-dose ESW (LD-ESW; 0.06 mJ/mm2, 4 Hz, 1500 impulses), and high-dose ESW (HD-ESW; 0.43 mJ/mm2, 4 Hz, 1500 impulses). The TBI shielding was removed at week 4 after partial patellectomy, followed by treatment with control or ESW at week 6. The rabbits were euthanized at week 8 and week 12 for radiological, microarchitectural, histological, and mechanical assessments of healing tissues. Results: Radiologically, both the LD-ESW group and the HD-ESW group showed larger new bone area than the controls at week 8 and week 12. Microarchitectural measurements showed that the LD-ESW and HD-ESW groups had larger new bone volume than the controls at week 12. Histological assessments confirmed osteogenesis enhancement. Both the LD-ESW and HD-ESW groups showed significantly higher failure load at the TBI healing complex than the control group at week 12. No significant difference was detected between the 2 ESW treatment groups at week 8 or week 12. Conclusion: Extracorporeal shockwave, a unique noninvasive physical modality, had similar effects between the low and high dose for treating delayed TBI healing. Clinical Relevance: Low-dose ESW for TBI delayed healing might be more desirable and have better compliance in clinical applications.