bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal evidence of the association between green and blue spaces (GBS) and maternal and neonatal health: a systematic review and meta-analysis protocol
Authors: Khalaf Rukun K.S. , Akaraci Selin , Baldwin Faye D. , Geary Rebecca S. , Kolamunnage-Dona Ruwanthi , Hunter Ruth F. , Rodgers Sarah E. 
Published: August 2024

IntroductionPrevious systematic reviews investigating the effects of green and blue space (GBS) on maternal and neonatal health have mainly focused on cross-sectional evidence, limiting potential causal inferences. The last review on the topic was published in January 2024. This review focused on residential greenness effects and neonatal health only but did not include other green/blue space measures, or maternal health outcomes. This review also only included papers published up to June 2023; discounting the 15 studies that have been published since. Thus, this study will capture the growing number of studies that generate causal evidence and aims to investigate the association between GBS and maternal and/or neonatal health.Methods and analysisThe study protocol was developed with reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This review will include study designs such as experiments, quasi-experiments, longitudinal studies and more. The study independent variable must be a GBS, green space and/or blue space measure. Eligible maternal health outcomes are those reported during pregnancy and up to 1 year after pregnancy. Neonatal health outcomes are limited to neonates no older than 28 days. A total of seven online databases will be searched: Medline, Scopus, Web of Science, PsycInfo, Embase, Environment Complete, and Maternity and Infant Care Database. Abstract and full-text screenings will be undertaken by three reviewers. Risk of bias assessment will be conducted based on the Risk of Bias in Non-randomized Studies-of Exposure framework.A narrative synthesis will be undertaken. If sufficiently comparable studies are identified, meta-analyses using random effects models will be conducted. We will explore heterogeneity using the I2test.Ethics and disseminationEthical approval is not required as all the data will be derived from published primary studies that have already obtained ethical permissions. The findings will be disseminated through relevant conferences and peer-reviewed publications.PROSPERO registration numberCRD42023396372.
Analyses of the association betweenHelicobacter pyloriantibody titre and pathogenicity before and after eradication: results of the Kyushu and Okinawa population study, a retrospective observational cohort study
Authors: Yamasaki Sho , Murata Masayuki , Ohta Azusa , Matsumoto Yuji , Ikezaki Hiroaki , Furusyo Norihiro 
Published: August 2024

ObjectivesTo assess the utility ofHelicobacter pyloriantibody testing, we evaluated the correlation between theH. pyloriantibody titre andH. pylori-associated pathogenicity and the changes in antibody titre afterH. pylorieradication therapy.DesignA retrospective observational cohort study.Setting and participantsFrom 2004 to 2016, medical check-ups were performed in different regions of Japan. In total, 324 subjects infected withH. pyloriwho receivedH. pylorieradication therapy were enrolled;H. pyloriwas eradicated in 266 of these subjects. We examined the associations betweenH. pyloriantibody titre with pepsinogen and the presence or absence ofH. pylori-associated pathogenic proteins, such as cytotoxin-associated gene A and vacuolating cytotoxin gene A, at baseline and afterH. pylorieradication therapy.ResultsTheH.pyloriantibody titre showed a positive correlation with pepsinogen II and a negative correlation with the pepsinogen I/II ratio. Moreover, theH.pyloriantibody titre significantly correlated with the positive rates ofH. pylori-associated pathogenic protein before eradication therapy. Antibody titres decreased after eradication, the pepsinogen I/II ratio increased and theH. pylori-associated pathogenic protein-positive rate decreased in patients with successful eradication. The determination of eradication using the decline in antibody titre 6 months after eradication therapy was useful (area under the receiver operating characteristic curve: 0.98).ConclusionsOur data indicate that theH. pyloriantibody titre may represent the degree of pathogenicity. TheH. pyloriantibody titre was associated with attenuation of pathogenicity in patients withH. pylorieradication, indicating the clinical utility ofH. pyloriantibody testing.
Comparative effect of different mindfulness-based intervention types and deliveries on depression in patients with breast cancer: a protocol for a systematic review and network meta-analysis
Authors: Zhang Deqi , Zhao Wenxin , Yuan Lin , Chen Qiang , Xu Qiling , Jiang Xiaoyu , Bi Hongyan 
Published: August 2024

IntroductionBreast cancer has become the most common cancer worldwide. Various types of mindfulness-based interventions (e.g., mindfulness-based cognitive therapy, mindfulness-based stress reduction) have been conducted in different delivery methods (including face to face and internet delivered) to help patients with breast cancer mitigate their depression. However, at present, there are no studies that compare the effectiveness of all these types and deliveries of mindfulness-based interventions. Therefore, this protocol aims to conduct a systematic review and network meta-analysis to assess the effectiveness of various types and deliveries of mindfulness-based interventions in mitigating depression in patients with breast cancer.MethodsThis protocol is according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The electronic databases, including PubMed, Web of Science, the Cochrane Library, Embase, Google Scholar, The China National Knowledge Infrastructure and OpenGrey, will be comprehensively retrieved for related randomised controlled trials (RCTs) from inception to December 2023. Two reviewers will independently assess the risk of bias using the Cochrane Risk of Bias Tool for Randomised Trials 2.0 (RoB 2.0). The network meta-analysis will be performed using the STATA V.16.0, and the assessment of heterogeneity, inconsistency, publication bias, evidence quality, subgroup analyses and sensitivity analyses will be conducted.Ethics and disseminationThis protocol does not require approval from an ethics committee as it is based on previous research findings. The results will be disseminated via peer-reviewed publications.PROSPERO registration numberCRD42024495996.
Is there an association between serum 25-hydroxyvitamin D concentrations and obstructive sleep apnoea? A cross-sectional analysis of NHANES 2007–2008 data
Authors: Li Qingyuan , Yao Jun , Duan Ran , Feng Tong 
Published: August 2024

ObjectivesThe study aimed to investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and obstructive sleep apnoea (OSA) and to assess the confounding effect of body mass index (BMI) on this relationship.DesignThis was a cross-sectional analysis using data from the 2007–08 National Health and Nutrition Examination Survey (NHANES).SettingData were sourced from NHANES, a continuous survey sponsored by the Centres for Disease Control and Prevention, covering residents from 15 urban areas in the United States of America(USA).ParticipantsThe study included 4901 participants aged 16 years and older who had completed 25(OH)D data and responses to the OSA questionnaire.Main exposure measureSerum 25(OH)D concentrations were measured using liquid chromatography-tandem mass spectrometry.Main outcome measureThe primary outcome was the self-reported diagnosis of OSA from questionnaires.ResultsAfter adjusting for age, sex and race (model 1), a significant negative association was observed between 25(OH)D and OSA (β=−3.21, 95% CI: −6.17 to –0.26). However, this association was no longer significant after further adjustment for BMI (model 2) (β=1.47, 95% CI: −1.48, 4.42). In the fully adjusted model (model 3), there was no significant association between 25(OH)D and OSA (β=0.92, 95% CI: −1.93, 3.76). Subgroup analyses stratified by sex, age, race or BMI also revealed no significant associations between 25(OH)D and OSA.ConclusionsThe study found no significant association between 25(OH)D and OSA. The observed correlation between lower levels of 25(OH)D and OSA may be due to confounding factors, such as higher BMI in the OSA group. Therefore, improving obesity management in OSA patients may be necessary to prevent 25(OH)D insufficiency. This underscores the importance of comprehensive management of both OSA and obesity to promote optimal health outcomes.
VIVALDI ASCOT and Ethnography Study: protocol for a mixed-methods longitudinal study to evaluate the impact of COVID-19 and other respiratory infection outbreaks on care home residents’ quality of life and psychosocial well-being
Authors: Bertini Lavinia , Schmidt-Renfree Nicola , Blackstone James , Stirrup Oliver , Adams Natalie , Cullen-Stephenson Iona , Krutikov Maria , Leiser Ruth , Goscé Lara , Henderson Catherine , Flowers Paul , Shallcross Laura , Cassell Jackie A , Cadar Dorina 
Published: August 2024

IntroductionOlder adults in care homes experienced some of the highest rates of mortality from SARS-CoV-2 globally and were subjected to strict and lengthy non-pharmaceutical interventions, which severely impacted their daily lives. The VIVALDI ASCOT and Ethnography Study aims to assess the impact of respiratory outbreaks on care home residents’ quality of life, psychological well-being, loneliness, functional ability and use of space. This study is linked to the VIVALDI-CT, a randomised controlled trial of staff’s asymptomatic testing and sickness payment support in care homes (ISRCTN13296529).Methods and analysisThis is a mixed-methods, longitudinal study of care home residents (65+) in Southeast England. Group 1—exposed includes residents from care homes with a recent COVID-19 or other respiratory infection outbreak. Group 2—non-exposed includes residents from care homes without a recent outbreak. The study has two components: (a) a mixed-methods longitudinal face-to-face interviews with 100 residents (n=50 from group 1 and n=50 from group 2) to assess the impact of outbreaks on residents’ quality of life, psychological well-being, loneliness, functional ability and use of space at time 1 (study baseline) and time 2 (at 3–4 weeks after the first visit); (b) ethnographic observations in communal spaces of up to 10 care homes to understand how outbreaks and related restrictions to the use of space and social activities impact residents’ well-being. The study will interview only care home residents who have the mental capacity to consent. Data will be compared and integrated to gain a more comprehensive understanding of the impact of outbreaks on residents’ quality of life and well-being.Ethics and disseminationThe VIVALDI ASCOT and Ethnography Study obtained ethical approval from the Health Research Authority (HRA) Social Care REC (24/IEC08/0001). Only residents with the capacity to consent will be included in the study. Findings will be published in scientific journals.
Density matrix renormalization group study of the interacting Kitaev chain with quasi-periodic disorder
Authors: Decker K. S. C. , Karrasch C. 
Published: August 2024

Abstract
We document the ground state phase diagram of the one-dimensional Kitaev chain with quasi-periodic disorder in the presence of two-body interactions. Our data were obtained for systems of $$L=1000$$

L
=
1000

sites using large-scale density-matrix renormalization group numerics and is benchmarked against known results for the clean system. We demonstrate that moderate quasi-periodic disorder stabilizes the topological phase both for repulsive and attractive interactions. For larger disorder strengths, the system features re-entrance behavior and multiple phase transitions.

Graphical abstract
Phase diagram as a function of the chemical potential and the disorder strength for repulsive interactions
Cardiopulmonary Exercise Testing‐Guided Exercise Therapy in Hypertensive Patients: A Single Center Study
Authors: Lu Qin , Lu Jingjing , Li Che , Huang Ping , Jiang Fenfen , Zhao Xia , Zhang Jianqin , Huang Yi , Chu Zhenliang 
Published: August 2024

Objective: To observe the effects of cardiac rehabilitation guided by cardiopulmonary exercise testing (CPET) on cardiorespiratory reserve function, blood pressure, blood pressure variability, and lipid metabolism in patients with hypertension.Methods: A randomized trial enrolled 67 Grade 1 hypertensive patients on antihypertensive drugs, divided into conventional (n = 35) and CPET (n = 32) groups. Antihypertensive drugs were not adjusted in both groups during the study period. Blood pressure, cardiorespiratory indicators, lipid profile, and BMI were assessed pre/post 12 weeks.Results: Postintervention, the CPET group exhibited significantly lower blood pressure levels and improved cardiac indicators compared to the conventional group (p < 0.05). CPET group showed greater improvements in cardiorespiratory endurance indicators (p < 0.05). The cardiorespiratory endurance indicators showed significantly greater increases in the CPET group compared to the conventional group (p < 0.05). Low‐density lipoprotein cholesterol (LDL‐C), total cholesterol (TC), triglycerides (TG), and body mass index (BMI) were significantly lower in the CPET group (p < 0.05).Conclusion: In addition to drug treatment, cardiac rehabilitation guided by CPET can effectively improve blood pressure control, reduce blood pressure variability, improve cardiorespiratory function and lipid metabolism, and increase exercise endurance in patients with Grade 1 hypertension. Its efficacy is clear and safe, with clinical value for promotion.
Loss of STK11 Suppresses Lipid Metabolism and Attenuates KRAS-Induced Immunogenicity in Patients with Non–Small Cell Lung Cancer
Authors: Principe Daniel R. , Pasquinelli Mary M. , Nguyen Ryan H. , Munshi Hidayatullah G. , Hulbert Alicia , Aissa Alexandre F. , Weinberg Frank 
Published: August 2024

Abstract

As many as 30% of the patients with non–small cell lung cancer harbor oncogenic KRAS mutations, which leads to extensive remodeling of the tumor immune microenvironment. Although co-mutations in several genes have prognostic relevance in KRAS-mutated patients, their effect on tumor immunogenicity are poorly understood. In the present study, a total of 189 patients with non–small cell lung cancer underwent a standardized analysis including IHC, whole-exome DNA sequencing, and whole-transcriptome RNA sequencing. Patients with activating KRAS mutations demonstrated a significant increase in PDL1 expression and CD8+ T-cell infiltration. Both were increased in the presence of a co-occurring TP53 mutation and lost with STK11 co-mutation. Subsequent genomic analysis demonstrated that KRAS/TP53 co-mutated tumors had a significant decrease in the expression of glycolysis-associated genes and an increase in several genes involved in lipid metabolism, notably lipoprotein lipase, low-density lipoprotein receptor, and LDLRAD4. Conversely, in the immune-excluded KRAS/STK11 co-mutated group, we observed diminished lipid metabolism and no change in anaerobic glycolysis. Interestingly, in patients with low expression of lipoprotein lipase, low-density lipoprotein receptor, or LDLRAD4, KRAS mutations had no effect on tumor immunogenicity. However, in patients with robust expression of these genes, KRAS mutations were associated with increased immunogenicity and associated with improved overall survival. Our data further suggest that the loss of STK11 may function as a metabolic switch, suppressing lipid metabolism in favor of glycolysis, thereby negating KRAS-induced immunogenicity. Hence, this concept warrants continued exploration, both as a predictive biomarker and potential target for therapy in patients receiving ICI-based immunotherapy.

Significance:
In patients with lung cancer, we demonstrate that KRAS mutations increase tumor immunogenicity; however, KRAS/STK11 co-mutated patients display an immune-excluded phenotype. KRAS/STK11 co-mutated patients also demonstrated significant downregulation of several key lipid metabolism genes, many of which were associated with increased immunogenicity and improved overall survival in KRAS-mutated patients. Hence, alteration to lipid metabolism warrants further study as a potential biomarker and target for therapy in patients with KRAS-mutated lung cancer.
Sociogeny beyond the Human: Race and Animality in Frantz Fanon and Patrick Chamoiseau
Authors: Oliver-Hobley Christie 
Published: August 2024

Abstract
Extending a recent turn at the interstice of Black and animal studies, this article analyzes two works by Martinican writers: Frantz Fanon’s (2008/1952) Black Skin, White Masks, and Patrick Chamoiseau’s (2018/1997) The Old Slave and the Mastiff. I read Fanon’s concept of “sociogeny” as an effort to conceptualize Black subjectivity within a reformulated analytic of European phenomenology, interpreting it as a non-anthroponormative mode of meaning-making that is independent of language or consciousness. In this light, Fanon’s human becomes an animal able to recognize their non-humanization. My interpretation of Chamoiseau highlights the implications of Fanon’s concept for understanding the coproduction and incommensurability of “race” and “animality.” Enslaved man and mastiff are subject to an identity that is not merely discursive but sociogenic, and both possess an agency that exceeds their subjectivation at the enslaver’s hands. Chamoiseau, I argue, directly represents what Fanon leaves only tacit: sociogeny beyond the human.
The First Conception of Modernist Chinese Buddhism
Authors: Gildow Douglas Matthew 
Published: August 2024

Abstract
Modernist Buddhist movements receptive to new social and intellectual developments have emerged around the globe since the late nineteenth century. This study probes the origins of Chinese modernist Buddhist thought, including its sources, features, and transformations. Through a survey of writings by turn-of-the-century Chinese intellectuals, I show that Liang Qichao 梁啟超 (1873–1929) was, in 1902, the first Chinese person to advocate modernist Buddhism. His ideas drew not only from Japanese modernist Buddhism, but also from Confucian discourse and from Western thought without Japanese mediation. Liang’s Buddhist thought incorporated features such as rationalism, social engagement, egalitarianism, and detraditionalization. He argued that if it were properly understood and practiced, Buddhism would strengthen China’s social order and could even transform the world into a “pure land” (jingtu). Liang’s modernist conception shaped later Chinese Buddhist movements, but only after it was cannibalized and its parts were modified for the purpose of reviving traditional Buddhism.
2. (Post)humanity
Authors: Tumino Stephen 
Published: August 2024

Chapter Two ("(Post)humanity") argues that increasing unevenness in capitalist relations have normalized an ethical turn in the humanities and led to the "posthumanities". The "post" of the posthumanities signals awareness of not only the exclusionary basis of the concept of Man, as did (post)structuralist post-humanist philosophy, but also represents a new sentimental embrace of non-human otherness and a Heideggerian ethics of care as "being-with" the animal(s) to respond to the growing social alienation of global capitalism and so one finds Derrida nakedly communing with his pet cat in The Animal That I Therefore Am and Haraway writing about making love with her dog through "oral intercourse" (Companion Species, 2-3) as if such sentimental attachments could remake "reality" (6). As in all "posts" (postfordist, postindustrial, poststructuralism, postmodern,... ), a cultural zone "beyond" the conflict between capital and labor is announced that naturalizes class inequality as the basis of human societies (Zavarzadeh 1).
The "post" of (post)structuralist post-humanism and the "post" of the new-er posthumanism are, despite their historical differences, ideologically the same—they attempt to "solve" in the theoretical imaginary contradictions that have arisen from the conflict between capital and labor. The founding texts of (post)structuralism were of course post-humanist but the opposition to humanism today has changed since Derrida and Foucault's critiques of humanism in the '60s and '70s and it is less concerned with deconstructing logocentrism and the languages of Man as it is with the cultural inscription of bodies around the human/animal distinction. I argue that these discursive changes are not driven by knowledge as in the dominant cultural theory but reflect changes in the mode of production.
Keywords: posthumanism; animal studies; Jacques Derrida; Donna Haraway; Wendy and Lucy; Slavoj Žižek; Alain Badiou.
The Kinematics of 3D Arm Movements in Sub-Acute Stroke: Impaired Inter-Joint Coordination is Attributable to Both Weakness and Flexor Synergy Intrusion
Authors: Avni Inbar , Arac Ahmet , Binyamin-Netser Reut , Kramer Shilo , Krakauer John W. , Shmuelof Lior 
Published: August 2024

Background It has long been of interest to characterize the components of the motor abnormality in the arm after stroke. One approach has been to decompose the hemiparesis phenotype into negative signs, such as weakness, and positive signs, such as intrusion of synergies. We sought to identify the contributions of weakness and flexor synergy to motor deficits in sub-acute stroke. Methods Thirty-three sub-acute post-stroke participants and 16 healthy controls performed two functional arm movements; one within flexor synergy (shoulder and elbow flexion), and the other outside flexor synergy (shoulder flexion and elbow extension). We analyzed upper limb 3D kinematics to assess both overall task performance and intrusion of pathological synergies. Weakness and spasticity were also measured. Results Both tasks produced similar impairments compared to controls. Analysis of elbow and shoulder multi-joint coordination patterns revealed intrusion of synergies in the out-of-synergy reaching task based on the time spent within a flexion-flexion pattern and the correlation between shoulder and elbow angles. Regression analysis indicated that both weakness and synergy intrusion contributed to motor impairment in the out-of-synergy reaching task. Notably, the Fugl-Meyer Assessment (FMA) was abnormal even when only weakness caused the impairment, cautioning that it is not a pure synergy scale. Conclusions Weakness and synergy intrusion contribute to motor deficits in the sub-acute post-stroke period. An abnormal FMA score cannot be assumed to be due to synergy intrusion. Careful kinematic analysis of naturalistic movements is required to better characterize the contribution of negative and positive signs to upper limb impairment after stroke.