bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic yield of ThinPrep preparation in the assessment of fine‐needle aspiration biopsy of salivary gland neoplasms
Authors: Hipp Jennifer , Lee Beatrice , Spector Matthew E. , Jing Xin 
Published: June 2014

BackgroundFine‐needle aspiration (FNA) has been widely recognized as an important modality in assessment of salivary gland neoplasms, and specimens are often processed as conventional smears. We conducted the current study to evaluate the diagnostic utility of ThinPrep preparation as an alternative method for assessment of salivary gland neoplasms.MethodsA computer SNOMED search from the pathology database at our institution between July 1999 and June 2012 was conducted to identify FNA cytology specimens of salivary gland lesions for which follow‐up surgical specimens revealed neoplasms. The FNA specimens were divided into two cohorts: one cohort consisted solely of the specimens in which all needle passes were collected into CytoLyt solution and only ThinPrep slides were prepared; and the other cohort included the specimens prepared with conventional smears. Diagnostic performance of the two cohorts was compared.ResultsNondiagnostic rate of ThinPrep preparation was significantly higher than that of conventional smears (40% vs.18%; P <0.001). Among the diagnostic specimens, although more indeterminate diagnoses were generated in ThinPrep preparation compared to conventional smears (40% vs. 26%; P = 0.024), absolute cytohistologic concordant rate for the positive cases (type of neoplasms specified) is similar between the two preparations (80% vs. 86%; P = 0.354). Furthermore, there is no significant difference in rate of accurate diagnosis (correct typing of benign versus malignant neoplasm) between the two preparations (70% vs. 81%; P = 0.057).ConclusionsThinPrep may be considered as another practical method of specimen preparation in the assessment of salivary gland neoplasms, particularly when FNA is performed without immediate assistance from cytology. Diagn. Cytopathol. 2015;43:98–104. © 2014 Wiley Periodicals, Inc.
Sulfonated Polymethylsiloxane as an Additive for Selective Calcium Oxalate Crystallization
Authors: Neira‐Carrillo Andrónico , Luengo‐Ponce Fabian , Vásquez‐Quitral Patricio , Yazdani‐Pedram Mehrdad , Fernández María Soledad , Cölfen Helmut , Arias José Luis 
Published: June 2014

AbstractSulfonated and fluorescent polymethylsiloxanes (SO3H‐PMS) were synthesized, and their effect as additives on in vitro calcium oxalate (CaOx) crystallization was evaluated. SO3H‐PMS was prepared by hydrosilylation and sulfonation reactions with poly(dimethylsiloxane‐co‐hydrogenmethylsiloxane) (PDMS‐co‐PMHS). Several analytical tools were used to investigate the morphology, crystal structure, and chemical contents of the harvested CaOx crystals. Varying the concentration of SO3H‐PMS induces a transition of CaOx monohydrate (COM) with expanded multilayer and circular stacked‐sheet morphologies as well as of the bipyramidal CaOx dihydrate (COD) crystals in three crystallization procedures. Energy‐dispersive X‐ray spectroscopy (EDS) and XRD allowed detecting the presence of Si (0.2–1.0°wt.‐%), which stems from SO3H‐PMS adsorbed on CaOx, and the selective formation of phases of COM and COD. We demonstrated that the presence of anionic moieties on the SO3H‐PMS backbone and their concentration were crucial to control the crystal type, morphology, crystal size, and chemical composition.
Solid‐State NMR Characterization of Paramagnetic Bis(L‐valinato)copper(II) Stereoisomers – Effect of Conformational Disorder and Molecular Mobility on 13C and 2H Fast Magic‐Angle Spinning Spectra
Authors: Szalontai Gábor , Sabolović Jasmina , Marković Marijana , Szabolcs Balogh and 
Published: June 2014

AbstractThe solid‐state 13C and 2H NMR spectra of paramagnetic anhydrous trans‐bis(L‐valinato)copper(II) and cis‐aquabis(L‐valinato)copper(II) complexes have been obtained. Under the very fast MAS conditions, both the 13C and 2H MAS spectra were well enough resolved to allow the easy distinction between the trans and cis stereoisomers. The conformational disorder observed previously in the X‐ray structure of the cis isomer was also reflected in the 13C and 2H MAS spectra. Variable‐temperature 2H MAS spectra of differently deuterated ligand species, that is, the copper(II) complexes with L‐[D2]valine, L‐[D8]valine, and L‐[D10]valine, suggested the dynamic nature of this disorder in the aqua cis isomer and confirmed static ND2 deuterons in the anhydrous trans isomer. Quantum chemical DFT/B3LYP calculations of the 13C hyperfine (Fermi contact) shifts of the paramagnetic term were useful as assignment aids in the interpretation of the 13C MAS spectra.
Coexistence of Localized and Itinerant Electrons in the Double‐Perovskite Ba2Fe2/3Mo4/3O6
Authors: López Carlos A. , Saleta Martín E. , Pedregosa José C. , Sánchez Rodolfo D. , Alonso José A. , Fernández‐Díaz María T. 
Published: June 2014

AbstractA polycrystalline Ba2Fe2/3Mo4/3O6 double‐perovskite has been prepared by decomposition of citrate precursors and subsequent thermal treatment under a reducing atmosphere. The crystal structure has been studied by combined X‐ray and neutron powder diffraction (XRPD and NPD). At room temperature, the structure is cubic (Fm$\bar {3}$m) with lattice parameter a = 8.0710(1) Å. It is unchanged between 3 and 320 K. The crystallographic formula is Ba2[Fe0.52(2)Mo0.48(2)]4a[Fe0.14(2)Mo0.86(2)]4bO5.9(2). NPD, electron spin resonance (ESR), and magnetization measurements show spontaneous magnetization below the Curie temperature (TC) = 310 K. The ESR behavior is associated with the presence of localized Fe3+ ions, whereas the transport properties (electrical conductivity and Seebeck effect) suggest the presence of highly correlated electrons in a metallic band with disorder, which can be associated with the Mo t2g electrons. The coexistence of localized and itinerant electrons leads to non‐negligible magnetoresistance properties.
New Members of a Class of Monomeric {Fe(NO)2}10 Dinitrosyliron Complexes and a Dimeric {Fe(NO)2}10–{Fe(NO)2}10 Dinitrosyliron Complex
Authors: Lo Feng‐Chun , Ho Yi‐Chieh , Chang Po‐Ya , Lee Gene‐Hsiang , Kuo Ting‐Shen , Chen Jeng‐Lung , Chen Chien‐Hong 
Published: June 2014

AbstractThe monomeric {Fe(NO)2}10 dinitrosyliron complexes (DNICs) [K‐18‐crown‐6‐ether][(NO)2Fe(NC9H6‐NH)] (1), [K‐18‐crown‐6‐ether][(NO)2Fe(NC9H6‐O)] (2), and [K‐18‐crown‐6‐ether][(NO)2Fe(NC9H6‐S)] (3) containing [N,NH], [N,O], and [N,S] ligations were synthesized by displacing the N,N,N′,N′‐tetramethylethylenediamine (tmeda) group of {Fe(NO)2}10 (tmeda)Fe(NO)2 with quinolin‐8‐amide, quinolin‐8‐olate, and quinolin‐8‐thiolate, respectively. Anionic {Fe(NO)2}10 DNICs 1–3 were characterized by IR, 1H NMR, and UV/Vis spectroscopy and single‐crystal X‐ray diffraction. The binding affinity of the ligands (i.e., [NC9H6NH]–, [NC9H6O]–, and [NC9H6S]–) toward the {Fe(NO)2}10 fragment was also investigated, and ligand substitution was found to follow the order [NC9H6S]– > [NC9H6O]– > [NC9H6NH]–. Displacement of the tmeda group of (tmeda)Fe(NO)2 by [K‐18‐crown‐6‐ether][SC6H4‐o‐NH2] and [PPh4][SC6H4‐o‐NH2] afforded monomeric {Fe(NO)2}10 DNIC [K‐18‐crown‐6‐ether][(NO)2Fe(SC6H4‐o‐NH2)] (4) and dimeric {Fe(NO)2}10–{Fe(NO)2}10 DNIC [PPh4]2[(NO)2Fe(μ‐SC6H4‐o‐NH2)]2 (5), respectively. The function of the countercation in the formation of monomeric {Fe(NO)2}10 DNIC 4 or dimeric {Fe(NO)2}10–{Fe(NO)2}10 DNIC 5 was also demonstrated upon reduction of the {Fe(NO)2}9 DNICs [cation][(NO)2Fe(SC6H4‐o‐NH2)2] (6) {cation = K‐18‐crown‐6‐ether (6a), [PPh4] (6b)}. In contrast to the formation of thiolate‐containing {Fe(NO)2}9 DNICs through nucleophilic cleavage of the bridging thiolates of Roussin's red esters, the transformation of complexes 4 and 5 into complexes 6a and 6b, respectively, in the presence of disulfide provides a new synthetic pathway for the synthesis of thiolate‐containing {Fe(NO)2}9 DNICs.
Selective prevention of mechanical hyperalgesia after incision by spinal ERK1/2 inhibition
Authors: van den Heuvel I. , Reichl S. , Segelcke D. , Zahn P.K. , Pogatzki‐Zahn E.M. 
Published: June 2014

AbstractBackgroundActivation of extracellular signal‐regulated kinases (ERK1/2) has been shown to play an important role in several pain states. Here we investigated the ERK1/2 contribution to non‐evoked and evoked pain‐like behaviour in rats after surgical incision.MethodsSpinal phosphorylation of ERK1 and ERK2 was assessed 15 min, 4 h, 24 h and 5 days after plantar incision and sham incision. The effect of PD98059, a specific inhibitor of ERK1/2 activation, administered intrathecally (IT) 1 h before or 2 h after incision on spinal ERK1 and ERK2 phosphorylation was assessed. In behavioural experiments, the effect of PD98059 administered 1 h before or after incision on non‐evoked pain behaviour and mechanical and heat hyperalgesia was assessed.ResultsPhosphorylated ERK1 and ERK2 were rapidly increased in the ipsilateral dorsal horn from rats after incision post‐operatively. This increased ERK1 and ERK2 phosphorylation were blocked by PD98059 administered before incision. In congruence, IT administration of PD98059 before incision delayed mechanical hyperalgesia after incision; however, administration after incision had only a modest effect on mechanical hyperalgesia. In addition, PD98059 did not affect non‐evoked pain behaviour or heat hyperalgesia after incision.ConclusionThe results suggest that spinal ERK1 and ERK2 are involved in regulation of pain after incision differentially with regard to the pain modality. Furthermore, blockade of ERK1/2 activation was most effective in a preventive manner, a condition which is rare after incision. Spinal ERK1/2 inhibition could therefore be a very useful tool to manage selectively movement‐evoked pain after surgery in the future.
Im Brennglas eines Diariums
Authors: Unterstell Rembert 
Published: June 2014

AbstractAlltag im Dreißigjährigen Krieg: Mehr als 35 Jahre lang führte Christian II. von Anhalt‐Bernburg Tagebuch — tiefe Einblicke in Wirklichkeiten fern der großen Schlachtfelder. Nun wird das ungewöhnliche Selbstzeugnis in einem Langfristvorhaben digital ediert — als neues Rechercheinstrument und als Forschungslaboratorium für die Digital Humanities.
Quantenstatt Karat
Authors: Wrachtrup Jörg 
Published: June 2014

AbstractDieselben Eigenschaften, die Diamanten zu spektakulären Edelsteinen machen, begründen auch ihre hervorragenden Einsatzmöglichkeiten in der Quantentechnologie. Eine Forschergruppe untersucht die quantenphysikalischen Grundlagen des Materials und eröffnet so neue Wege für Halbleitertechnologie, Quanteninformationsverarbeitung und Medizin.
Breiter Ansatz
Authors: Blüher Matthias 
Published: June 2014

AbstractAdipositas ist längst ein Volksleiden. Doch Stoffwechdie Faktoren und Mechanismen, die Fettleibigkeit begünstigen und auslösen, müssen noch deutlich besser verstanden und aufeinander bezogen werden. In aktuellen Studien rücken nun vor allem das Fettgewebe im Körper sowie die Aktivitäten von Hormonen und Entzündungen in den Blick medizinischer Grundlagenforscher.
Clinical experience with aspiration of breast abscesses based on size and etiology at an academic medical center
Authors: Giess Catherine S. , Golshan Mehra , Flaherty Karen , Birdwell Robyn L. 
Published: June 2014

ABSTRACTPurposeOur purpose was to review needle aspiration of breast abscesses and identify factors associated with treatment by aspiration alone versus aspiration with surgical incision and drainage (I/D).MethodsThis Institutional Review Board–approved, retrospective review of the breast ultrasound database from 2008 to 2010 identified 40 patients (41 abscesses) who underwent aspiration, with or without I/D. Demographics, imaging, number of aspirations, and microbiology were reviewed.ResultsTwenty‐two abscesses underwent aspiration only, 16 > 3 cm, 6 ≤ 3 cm (mean 4.3 cm, range 0.9–10 cm). Known risk factors included lactational (11), 3 weeks post partum (1), pregnancy (1), recent biopsy/lumpectomy (5). Nineteen abscesses underwent aspiration and I/D, 15 > 3 cm, 4 ≤ 3 cm (mean 4.1 cm, range 2.2–7.5 cm). Known risk factors included lactational (4), recurrent subareolar abscess (4), diabetes (3), hydradenitis suppuritiva (1), nipple piercing (2), smoking (1), pregnancy (1), HIV (1), and lumpectomy (1). Identified reasons for I/D included lack of improvement/recurrence (12), fistula (3), and one electively after clinical improvement of a recurrent subareolar abscess.ConclusionsAbscesses associated with pregnancy and lactation or breast biopsy are effectively managed with aspiration, even when large. Recurrence, chronicity, or fistula may require surgical intervention. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 42:513–521, 2014
An examination of the sensory structures in the oral cavity of the American alligator (Alligator mississippiensis)
Authors: Rehorek Susan J. , Duffy Michael , Zacherl Janelle R. , Anand Kusuma , Elsey Ruth M. , Smith Timothy S. 
Published: June 2014

ABSTRACTThe location and distribution of mucosal sensory structures of the crocodilian oral cavity are poorly understood. Although there are several descriptions of these structures in adults, nothing is known about their development. The purpose of this study was to document location, morphology, and relative abundance of these mucosal sensory structures in both hatchling and subadult alligators. Numerous mucosal sensory structures and pale staining dome‐shaped papillae were observed only in the upper palate and tongue. In hatchlings, these papillae, which house either mechanoreceptive or chemosensory (taste buds) structures, were larger and more prevalent on the tongue than the upper palate. In the subadult, however, these papillae housed primarily mechanoreceptive structures and possibly degenerate taste buds. Although the presence of the mechanoreceptive structures in the palates of the suabadult alligator are to be expected, the loss of most taste buds is hitherto undocumented. Thus, there is morphological support for an ontogenetic shift in the role of the sensory palate, from a prey detection gustatory sensory system in hatchlings to a prey‐manipulative mechanoreceptive system in subadults. J. Morphol. 275:1312–1320, 2014. © 2014 Wiley Periodicals, Inc.
Effects of organic and other management practices on soil nematode communities in tea plantation: a case study in southern China
Authors: Li Xingyue , Liu Qizhi , Liu Zhilong , Shi Wangpeng , Yang Daowei , Tarasco Eustachio 
Published: June 2014

AbstractFour major tea management practices (organic, pollution‐free, conventional, and semi‐natural) are employed in Chinese tea plantations at present. These practices can induce changes in the physiochemical parameters, microorganism community and enzyme activity in tea plantation soil. However, understanding of their effects on soil nematodes is still scarce. This study aimed to investigate whether and how different management practices affect the biodiversity, function, and structure of soil nematode communities in tea plantation habitats. The soil nematode community structures and ecological indices were determined from the soil samples collected more than 6 y after their respective farming practices were first applied, and different management practices did not greatly affect soil nematode community evenness or species diversity, but organic practice increased nematode trophic diversity, common species diversity, and species richness. Pollution‐free practice considerably increased fungivorous nematodes, and both pollution‐free and conventional practice decreased bacterivorous nematodes markedly in the subsurface layers of soil. Predator and omnivorous nematodes were found to be more abundant in semi‐natural plantation. Organic practice was more sustainable and suitable for tea cultivation, with the greatest biodiversity, best nutrient conditions, higher and more stable C/N ratio and lower interference in the food web.
Novel super fast response vertical alignment‐liquid crystal display with extremely wide temperature range
Authors: Iwata Yosuke , Murata Mitsuhiro , Tanaka Kohei , Ohtake Tadashi , Yoshida Hidefumi , Miyachi Koichi 
Published: June 2014

AbstractWe have developed a novel super fast response (SFR) thin‐film transistor liquid crystal display (TFT‐LCD) with an extremely wide temperature range. Nematic liquid crystal molecules with positive dielectric anisotropy are vertically aligned initially. Any gray‐to‐gray response is forcibly controlled by applying an electric field. Response times of the SFR TFT‐LCD are over several times shorter than those of conventional LCDs such as vertical alignment or in‐plane switching LCDs.
Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane
Authors: Bricker Gregory V. , Riedl Kenneth M. , Ralston Robin A. , Tober Kathleen L. , Oberyszyn Tatiana M. , Schwartz Steven J. 
Published: June 2014

ScopeBroccoli sprouts are a rich source of glucosinolates, a group of phytochemicals that when hydrolyzed, are associated with cancer prevention. Our objectives were to investigate the metabolism, distribution, and interconversion of isothiocyanates (ITCs) in mice fed thermally processed broccoli sprout powders (BSPs) or the purified ITC sulforaphane.Methods and resultsFor 1 wk, mice were fed a control diet (n = 20) or one of four treatment diets (n = 10 each) containing nonheated BSP, 60°C mildly heated BSP, 5‐min steamed BSP, or 3 mmol purified sulforaphane. Sulforaphane and erucin metabolite concentrations in skin, liver, kidney, bladder, lung, and plasma were quantified using HPLC‐MS/MS. Thermal intensity of BSP processing had disparate effects on ITC metabolite concentrations upon consumption. Mild heating generally resulted in the greatest ITC metabolite concentrations in vivo, followed by the nonheated and steamed BSP diets. We observed interconversion between sulforaphane and erucin species or metabolites, and report that erucin is the favored form in liver, kidney, and bladder, even when only sulforaphane is consumed.ConclusionITC metabolites were distributed to all tissues analyzed, suggesting the potential for systemic benefits. We report for the first time tissue‐dependent ratio of sulforaphane and erucin, though further investigation is warranted to assess biological activity of individual forms.
Generating multiple contrasts using single‐shot radial T1 sensitive and insensitive steady‐state imaging
Authors: Benkert Thomas , Bartsch Andreas J. , Blaimer Martin , Jakob Peter M. , Breuer Felix A. 
Published: June 2014

PurposeRecently, the (Resolution Enhanced‐) T1 insensitive steady‐state imaging (TOSSI) approach has been proposed for the fast acquisition of T2‐weighted images. This has been achieved by balanced steady‐state free precession (bSSFP) imaging between unequally spaced inversion pulses. The purpose of this work is to present an extension of this technique, considerably increasing both the efficiency and possibilities of TOSSI.Theory and MethodsA radial trajectory in combination with an appropriate view‐sharing reconstruction is used. Because each projection traverses the contrast defining k‐space center, several different contrasts can be extracted from a single‐shot measurement. These contrasts include various T2‐weightings and T2/T1‐weighting if an even number of inversion pulses is used, while an odd number allow the generation of several images with predefined tissue types cancelled.ResultsThe approach is validated for brain and abdominal imaging at 3.0 Tesla. Results are compared with RE‐TOSSI, bSSFP, and turbo spin‐echo images and are shown to provide similar contrasts in a fraction of scan time. Furthermore, the potential utility of the approach is illustrated by images obtained from a brain tumor patient.ConclusionRadial T1 sensitive and insensitive steady‐state imaging is able to generate multiple contrasts out of one single‐shot measurement in a short scan time. Magn Reson Med 73:2129–2141, 2015. © 2014 Wiley Periodicals, Inc.
Advantages and problems with pregnancy registries: observations and surprises throughout the life of the International Lamotrigine Pregnancy Registry
Authors: Sinclair Susan , Cunnington Marianne , Messenheimer John , Weil John , Cragan Janet , Lowensohn Richard , Yerby Mark , Tennis Patricia 
Published: June 2014

ABSTRACTPurposeThe International Lamotrigine Pregnancy Registry monitored for a signal of a substantial increase in the frequency of major congenital malformations associated with lamotrigine exposures in pregnancy over an 18‐year period. Key methodological lessons are discussed.MethodsThe strengths and weaknesses of the Registry were assessed using quantifiable methodological and operational parameters including enrollment, completeness of exposure and outcome data reporting, and lost to follow‐up. The choice of comparator groups and stopping rules for registry closure were critically evaluated.ResultsThe reliance on voluntary reporting was associated with a clustered geographical distribution of registered pregnancies. The enrollment rate increased over time with new approvals and indications for lamotrigine and publication of interim data. Reporter burden was minimized through a streamlined data collection approach resulting in a high level of completeness of exposure and primary outcome data. Lost to follow‐up rates were high (28.5% overall) representing a major limitation; incentives to increase the completeness of reporting failed to reduce rates. A lack of an internal comparator group complicated data interpretation; but external comparisons with multiple external groups allowed an assessment of consistency of outcome data across multiple data sources. A lack of a priori closure criteria prolonged the life of the Registry, and consideration of regulatory guidelines on this subject is encouraged at the time of conception of future registries.ConclusionsA successful pregnancy exposure registry requires ongoing flexibility and continuous re‐assessment of enrollment, recruitment, and retention methods and the availability of comparison data, throughout its lifecycle. Copyright © 2014 John Wiley & Sons, Ltd.
Non‐commutative geometry in higher dimensional quantum hall effect as A‐class topological insulator
Authors: Hasebe K. 
Published: June 2014

AbstractWe clarify relations between the higher dimensional quantum Hall effect and A‐class topological insulator. In particular, we elucidate physical implications of the higher dimensional non‐commutative geometry in the context of A‐class topological insulator. This presentation is based on the author's recent work [1].