bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice
Authors: Dimet-Wiley Andrea L. , Latham Christine M. , Brightwell Camille R. , Neelakantan Harshini , Keeble Alexander R. , Thomas Nicholas T. , Noehren Haley , Fry Christopher S. , Watowich Stanley J. 
Published: July 2024

AbstractHuman hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising treatment for sarcopenia. Since human hallmarks of sarcopenia are recapitulated in aged (24-month-old) mice, we treated mice from 22 to 24 months of age with NNMTi, intensive exercise, or a combination of both, and compared skeletal muscle adaptations, including grip strength, longitudinal running capacity, plantarflexor peak torque, fatigue, and muscle mass, fiber type, cross-sectional area, and intramyocellular lipid (IMCL) content. Exhaustive proteome and metabolome analyses were completed to identify the molecular mechanisms underlying the measured changes in skeletal muscle pathophysiology. Remarkably, NNMTi-treated aged sedentary mice showed ~ 40% greater grip strength than sedentary controls, while aged exercised mice only showed a 20% increase relative to controls. Importantly, the grip strength improvements resulting from NNMTi treatment and exercise were additive, with NNMTi-treated exercised mice developing a 60% increase in grip strength relative to sedentary controls. NNMTi treatment also promoted quantifiable improvements in IMCL content and, in combination with exercise, significantly increased gastrocnemius fiber CSA. Detailed skeletal muscle proteome and metabolome analyses revealed unique molecular mechanisms associated with NNMTi treatment and distinct molecular mechanisms and cellular processes arising from a combination of NNMTi and exercise relative to those given a single intervention. These studies suggest that NNMTi-based drugs, either alone or combined with exercise, will be beneficial in treating sarcopenia and a wide range of age-related myopathies.
Prediction of optical properties of rare-earth doped phosphate glasses using gene expression programming
Authors: Ahmadi Fahimeh , El-Mallawany Raouf , Papanikolaou Stefanos , Asteris Panagiotis G. 
Published: July 2024

AbstractThe progression of optical materials and their associated applications necessitates a profound comprehension of their optical characteristics, with the Judd–Ofelt (JO) theory commonly employed for this purpose. However, the computation of JO parameters (Ω2, Ω4, Ω6) entails wide experimental and theoretical endeavors, rendering traditional calculations often impractical. To address these challenges, the correlations between JO parameters and the bulk matrix composition within a series of Rare-Earth ions doped sulfophosphate glass systems were explored in this research. In this regard, a novel soft computing technique named genetic expression programming (GEP) was employed to derive formulations for JO parameters and bulk matrix composition. The predictor variables integrated into the formulations consist of JO parameters. This investigation demonstrates the potential of GEP as a practical tool for defining functions and classifying important factors to predict JO parameters. Thus, precise characterization of such materials becomes crucial with minimal or no reliance on experimental work.
Reasoning with the inverse of 3D cardinal direction relations based on direction matrices
Authors: Wang Miao , Dong Xingxing , Gao Jixun , Fang Zhenxi , Tang Hao , Li Song 
Published: July 2024

AbstractIn order to improve the ability of intelligent reasoning and prediction of 3DR27 model which presented in our previous work, enhance the usability of this model, and better fulfill the demands of real applications for spatial database, we focused on the problem of reasoning with the inverse of 3D cardinal direction relations between spatial objects. In order to realize automated reasoning, an algorithm for computing the inverse of 3D cardinal direction relations based on matrices is proposed on the basis of the mapping between the 3D rectangular cardinal direction relations and 3D interval relation matrix. This algorithm improves the power of reasoning for this model by means of the excellent properties of matrix operations. Theorems are provided to prove formally that our algorithm is correct and complete. This study realized the automatic inference and calculation of the inverse of the 3D cardinal direction relations based on 3DR27 model and further improved the ability of spatial reasoning and spatial analysis of spatial database.
Microscopic evaluation of spin and orbital moment in ferromagnetic resonance
Authors: Ishii Yuta , Yamasaki Yuichi , Kozuka Yusuke , Lustikova Jana , Nii Yoichi , Onose Yoshinori , Yokoyama Yuichi , Mizumaki Masaichiro , Adachi Jun-ichi , Nakao Hironori , Arima Taka-hisa , Wakabayashi Yusuke 
Published: July 2024

AbstractTime-resolved X-ray magnetic circular dichroism under the effects of ferromagnetic resonance (FMR), known as X-ray ferromagnetic resonance (XFMR) measurements, enables direct detection of precession dynamics of magnetic moment. Here we demonstrated XFMR measurements and Bayesian analyses as a quantitative probe for the precession of spin and orbital magnetic moments under the FMR effect. Magnetization precessions in two different Pt/Ni-Fe thin film samples were directly detected. Furthermore, the ratio of dynamical spin and orbital magnetic moments was evaluated quantitatively by Bayesian analyses for XFMR energy spectra around the Ni $$L_{2,3}$$

L

2
,
3

absorption edges. Our study paves the way for a microscopic investigation of the contribution of the orbital magnetic moment to magnetization dynamics.
Exposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden
Authors: Oudin Anna , Raza Wasif , Flanagan Erin , Segersson David , Jalava Pasi , Kanninen Katja M. , Rönkkö Topi , Giugno Rosalba , Sandström Thomas , Muala Ala , Topinka Jan , Sommar Johan 
Published: July 2024

AbstractThe aim of this study was to investigate the relationship between source-specific ambient particulate air pollution concentrations and the incidence of dementia. The study encompassed 70,057 participants from the Västerbotten intervention program cohort in Northern Sweden with a median age of 40 years at baseline. High-resolution dispersion models were employed to estimate source-specific particulate matter (PM) concentrations, such as PM10 and PM2.5 from traffic, exhaust, and biomass (mainly wood) burning, at the residential addresses of each participant. Cox regression models, adjusted for potential confounding factors, were used for the assessment. Over 884,847 person-years of follow-up, 409 incident dementia cases, identified through national registers, were observed. The study population’s average exposure to annual mean total PM10 and PM2.5 lag 1–5 years was 9.50 µg/m3 and 5.61 µg/m3, respectively. Increased risks were identified for PM10-Traffic (35% [95% CI 0–82%]) and PM2.5-Exhaust (33% [95% CI − 2 to 79%]) in the second exposure tertile for lag 1–5 years, although no such risks were observed in the third tertile. Interestingly, a negative association was observed between PM2.5-Wood burning and the risk of dementia. In summary, this register-based study did not conclusively establish a strong association between air pollution exposure and the incidence of dementia. While some evidence indicated elevated risks for PM10-Traffic and PM2.5-Exhaust, and conversely, a negative association for PM2.5-Wood burning, no clear exposure–response relationships were evident.
Green spaces contribute to structural resilience of the gut microbiota in urban mammals
Authors: Łopucki Rafał , Sajnaga Ewa , Kalwasińska Agnieszka , Klich Daniel , Kitowski Ignacy , Stępień-Pyśniak Dagmara , Christensen Henrik 
Published: July 2024

AbstractThe gut microbiome of wild animals is subject to various environmental influences, including those associated with human-induced alterations to the environment. We investigated how the gut microbiota of a synurbic rodent species, the striped field mouse (Apodemus agrarius), change in cities of varying sizes, seeking the urban microbiota signature for this species. Fecal samples for analysis were collected from animals living in non-urbanized areas and green spaces of different-sized cities (Poland). Metagenomic 16S rRNA gene sequencing and further bioinformatics analyses were conducted. Significant differences in the composition of gut microbiomes among the studied populations were found. However, the observed changes were dependent on local habitat conditions, without strong evidence of a correlation with the size of the urbanized area. The results suggest that ecological detachment from a more natural, non-urban environment does not automatically lead to the development of an “urban microbiome” model in the studied rodent. The exposure to the natural environment in green spaces may serve as a catalyst for microbiome transformations, providing a previously underestimated contribution to the maintenance of native gut microbial communities in urban mammals.
Research on bearing fault diagnosis based on improved genetic algorithm and BP neural network
Authors: Chen Zenghua , Zhu Lingjian , Lu He , Chen Shichao , Zhu Fenghua , Liu Sheng , Han Yunjun , Xiong Gang 
Published: July 2024

AbstractHealth monitoring and fault diagnosis of rolling bearings are crucial for the continuous and effective operation of mechanical equipment. In order to improve the accuracy of BP neural network in fault diagnosis of rolling bearings, a feature model is established from the vibration signals of rolling bearings, and an improved genetic algorithm is used to optimize the initial weights, biases, and hyperparameters of the BP neural network. This overcomes the shortcomings of BP neural network, such as being prone to local minima, slow convergence speed, and sample dependence. The improved genetic algorithm fully considers the degree of concentration and dispersion of population fitness in genetic algorithms, and adaptively adjusts the crossover and mutation probabilities of genetic algorithms in a non-linear manner. At the same time, in order to accelerate the optimization efficiency of the selection operator, the elite retention strategy is combined with the hierarchical proportional selection operation. Using the rolling bearing dataset from Case Western Reserve University in the United States as experimental data, the proposed algorithm was used for simulation and prediction. The experimental results show that compared with the other seven models, the proposed IGA-BPNN exhibit superior performance in both convergence speed and predictive performance.
Investigating structural and optoelectronic properties of Cr-substituted ZnSe semiconductors
Authors: Iqbal Muhammad Aamir , Bakhsh Sunila , Maidin Siti Sarah , Morsy Kareem , Choi Jeong Ryeol , Alguno Arnold C. 
Published: July 2024

AbstractThe optoelectronic and structural characteristics of the Zn1−xCrxSe (0 ≤ x ≤ 1) semiconductor are reported by employing density functional theory (DFT) within the mBJ potential. The findings revealed that the lattice constant decreases with increasing Cr concentration, although the bulk modulus exhibits the opposite trend. ZnSe is a direct bandgap material; however, a change from direct to indirect electronic bandgap has been seen with Cr presence. This transition is caused by structural alterations by Cr and defects forming, which results in novel optical features, including electronic transitions. The electronic bandgap decreases from 2.769 to 0.216 eV, allowing phonons to participate and improving optical absorption. A higher concentration of Cr boosts infrared absorption and these Cr-based ZnSe (ZnCrSe) semiconductors also cover a wider spectrum in the visible range from red to blue light. Important optical parameters such as reflectance, optical conductivity, optical bandgap, extinction coefficient, refractive index, magnetization factor, and energy loss function are discussed, providing a theoretical understanding of the diverse applications of ZnCrSe semiconductors in photonic and optoelectronic devices.
UAV telephotography elucidates floristic variability and beta diversity of island cliffs under grazing interventions
Authors: Kim Seongjun , Lee Chang Woo , Park Hwan-Joon , Hwang Jung Eun , Park Hyeong Bin , Yoon Young-Jun , Kim Yeong-Joong 
Published: July 2024

AbstractCliffs contain one of the least known plant communities, which has been overlooked in biodiversity assessments due to the inherent inaccessibility. Our study adopted the unmanned aerial vehicle (UAV) with the telephoto camera to remotely clarify floristic variability across unreachable cliffs. Studied cliffs comprised 17 coastal and 13 inland cliffs in Gageodo of South Korea, among which 9 and 5 cliffs were grazed by the introduced cliff-dwelling goats. The UAV telephotography showed 154 and 166 plant species from coastal and inland cliffs, respectively. Inland cliffs contained more vascular plant species (P < 0.001), increased proportions of fern and woody species (P < 0.05), and decreased proportion of herbaceous species (P < 0.001) than coastal cliffs. It was also found that coastal and inland cliffs differed in the species composition (P < 0.001) rather than taxonomic beta diversity (P = 0.29). Furthermore, grazed coastal cliffs featured the elevated proportions of alien and annual herb species than ungrazed coastal cliffs (P < 0.05). This suggests that coastal cliffs might not be totally immune to grazing if the introduced herbivores are able to access cliff microhabitats; therefore, such anthropogenic introduction of cliff-dwelling herbivores should be excluded to conserve the native cliff plant communities.
Oral antidiabetic therapy versus early insulinization on glycemic control in newly diagnosed type 2 diabetes patients: a retrospective matched cohort study
Authors: Lee Yang-Ming , Lin Pei Ru , Sia Hon-Ke 
Published: July 2024

AbstractOur study aims to compare the efficacy of oral antidiabetic therapy to early insulinization on glycemic control among newly diagnosed type 2 diabetes patients in real-world clinical practice. A retrospective cohort study conducted at a medical center in Taiwan analyzed 1256 eligible patients from January 2007 to December 2017. Propensity score matching resulted in well-balanced groups of 94 patients each in the oral antidiabetic drug (OAD) and early insulinization cohorts. Glycemic outcomes were assessed in both groups. Patients exclusively using OAD showed consistently lower glycated hemoglobin (HbA1c) levels at 3, 12, 24, and 36 months compared to insulin users. At later periods, 77.7% of OAD users achieved glycemic control versus 64.9% of insulin users, with a marginally significant difference. Subgroup analyses suggested a trend favoring well-controlled diabetes in the OAD group, though not statistically significant. Our study finds oral antidiabetic therapy is not inferior to early insulinization for glycemic control in newly diagnosed type 2 diabetes patients, irrespective of initial HbA1c levels. This supports oral therapy as a rational treatment option, even in cases with elevated HbA1c at diagnosis.
Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis
Authors: Moadab Fatemeh , Wang Xiaoxing , Le Ethan , Gazitt Tal , Najjar Rayan , Nelson J. Lee , Joshua Vijay , Malmström Vivianne , Elkon Keith , Grönwall Caroline , Mustelin Tomas 
Published: July 2024

AbstractAnti-citrullinated protein autoantibodies (ACPA) are diagnostic for rheumatoid arthritis (RA). The antigens recognized by these autoantibodies are produced by protein arginine deiminases (PADs), particularly PAD4. However, it remains unknown why and how PAD4 causes this aberrant citrullination in RA. Here, we report that poly-perforin pores are present on freshly isolated neutrophils from RA patients, but not on healthy donor neutrophils. Neutrophils with perforin pores also contained intracellular citrullinated proteins in the region adjacent to the pores. This response was replicated in vitro by treating neutrophils with purified perforin, which generated intense dots of anti-perforin immunofluorescence, calcium influx, and intracellular citrullination. Extensive neutrophil killing in Felty’s syndrome, an aggressive form of RA, correlated with particularly high ACPA, and PAD4 autoantibodies. In contrast, other forms of death, including NETosis, apoptosis, and pyroptosis, produced minimal citrullination. We conclude that neutrophil targeting by perforin leading to intracellular citrullination takes place in patients with RA.
Using wet-bulb globe temperature meters to examine the effect of heat on various tennis court surfaces
Authors: Yamaguchi Hiroki , Mori Takaaki , Hanano Hiromi , Oishi Kan , Ikeue Kentaro , Yamamoto Yuiko , Ishii Kojiro 
Published: July 2024

AbstractIn this study, we evaluated the thermal environments of different tennis courts using wet-bulb globe temperature (WBGT) meters. WBGT meters were installed in an outdoor hard court, sand-filled artificial grass court, and clay court (a softball field), and measurements were taken hourly from 9:00 to 17:00 on weekdays from June 1 to September 21, 2022. The results were compared with data from different courts and the nearest Japan Meteorological Agency station (JMA WBGT) based on the Japan Sports Association’s guidelines for exercise to prevent heat stroke. The median WBGT on each court was significantly higher for hard courts at the “Warning” (25 ≤ JMA WBGT < 28) level or above, sand-filled artificial grass courts at the “Severe Warning” (28 ≤ JMA WBGT < 31) level or above, and clay courts at the “Danger” (31 ≤ JMA WBGT) level than the JMA WBGT. Compared with the JMA WBGT, hard and sand-filled artificial grass courts are played on under particularly hot conditions. The results of this study could indicate to tournament organizers and coaches the importance of measuring the WBGT on each court surface from an early stage to prevent heat-related incidents.
Imagined speech event detection from electrocorticography and its transfer between speech modes and subjects
Authors: de Borman Aurélie , Wittevrongel Benjamin , Dauwe Ine , Carrette Evelien , Meurs Alfred , Van Roost Dirk , Boon Paul , Van Hulle Marc M. 
Published: July 2024

AbstractSpeech brain-computer interfaces aim to support communication-impaired patients by translating neural signals into speech. While impressive progress was achieved in decoding performed, perceived and attempted speech, imagined speech remains elusive, mainly due to the absence of behavioral output. Nevertheless, imagined speech is advantageous since it does not depend on any articulator movements that might become impaired or even lost throughout the stages of a neurodegenerative disease. In this study, we analyzed electrocortigraphy data recorded from 16 participants in response to 3 speech modes: performed, perceived (listening), and imagined speech. We used a linear model to detect speech events and examined the contributions of each frequency band, from delta to high gamma, given the speech mode and electrode location. For imagined speech detection, we observed a strong contribution of gamma bands in the motor cortex, whereas lower frequencies were more prominent in the temporal lobe, in particular of the left hemisphere. Based on the similarities in frequency patterns, we were able to transfer models between speech modes and participants with similar electrode locations.
Impact of solvation on the photoisomerisation dynamics of a photon-only rotary molecular motor
Authors: Filatov Michael , Paolino Marco , Kaliakin Danil , Olivucci Massimo , Kraka Elfi , Min Seung Kyu 
Published: July 2024

AbstractThe optimization of the quantum efficiency of single-molecule light-driven rotary motors typically relies on chemical modifications. While, in isolated conditions, computational methods have been frequently used to design more efficient motors, the role played by the solvent environment has not been satisfactorily investigated. In this study, we used multiscale nonadiabatic molecular dynamics simulations of the working cycle of a 2-stroke photon-only molecular rotary motor. The results, which display dynamics consistent with the available transient spectroscopy measurements, predict a considerable decrease in the isomerisation quantum efficiency in methanol solution with respect to the gas phase. The origin of such a decrease is traced back to the ability of the motor to establish hydrogen bonds with solvent molecules. The analysis suggests that a modified motor with a reduced ability to form hydrogen bonds will display increased quantum efficiency, therefore extending the set of engineering rules available for designing light-driven rotary motors.
A novel chitosan–PEG hydrogel embedded with in situ silver nanoparticles of Clerodendrum glandulosum Lindl. extract: evaluation of its in vivo diabetic wound healing properties using an image-guided machine learning model
Authors: Majie Ankit , Saha Rajdeep , Sarkar Arnab , Bhowmik Rudranil , Karmakar Sanmoy , Sharma Vishal , Deokar Kaushal , Haque Asad ul , Tripathy Sanjaya Shankar , Sarkar Biswatrish 
Published: July 2024

Clerodendrum glandulosum extract reduced silver nanoparticles were prepared by in situ technique within chitosan-PEG hydrogel matrix and characterized for its in vitro and in vivo diabetic wound healing activities.
Preventive DC‐side decoupling: A system integrity protection scheme to limit the impact of DC faults in offshore multi‐terminal HVDC systems
Authors: Düllmann Patrick , Klein Christopher , Winter Pascal , Köhler Hendrik , Steglich Michael , Teuwsen Jan , Leterme Willem 
Published: July 2024

AbstractTo create synergies between offshore wind integration and operational flexibility, interconnecting HVDC links to multi‐terminal networks is highly desired. However, its technical realisation remains a major challenge: In particular, it is crucial to prevent DC faults from leading to an intolerable loss of power infeed to the connected AC grids. To restrict this loss of power infeed, this paper proposes a concept for linear HVDC networks that is based on state‐of‐the‐art equipment only—that is, without dependence on DC circuit breakers. In this concept, the DC interconnection is preventively decoupled via DC high‐speed switches whenever the cumulative wind infeed exceeds the frequency containment reserve of the AC grid, but remains coupled at all other times. The decoupling is realised via controlling the coupling line current to zero through coordinated setpoint changes for the converters’ (VDC/P)‐droop controls. Both the decoupling sequence and the DC fault behaviour in decoupled state are validated via EMT simulations. In addition, limitations with regard to expandability are discussed. The proposed concept may not only limit the loss of infeed, but mitigates risks as a fall‐back level for more complex offshore (multi‐vendor) multi‐terminal HVDC topologies—and may thus accelerate their development at reasonable costs.