bluuebunny/crossref_metadata_2025_split huggingface dataset:
AACSB International’s 2013 accreditation standards
Authors: P. Miles Morgan , McClure Franklin Geralyn , Heriot Kirk , Hadley Linda , Hazeldine Mary 
Published: November 2014

Purpose
– The purpose of this paper is to consider the implications of the 2013 Association to Advance Collegiate Schools of Business (AACSB) Accreditation Standards for both business faculty and their deans who are responsible for implementing these changes.

Design/methodology/approach
– This paper is a speculative viewpoint on the implications of the 2013 AACSB standards by a set of a co-authors that include AACSB deans who are active in accreditation reviews and serve as mentors to schools in the accreditation process and senior faculty who have written self-studies for AACSB and served as consultants for schools seeking AACSB accreditation internationally.

Findings
– The implications of the 2013 AACSB business accreditation standards are arguably positive for active scholars holding a relevant doctoral degree. For example, active and engaged scholarly faculty should appreciate the ability to use additional indicators of the impact of their career’s intellectual contributions (IC) including, but not limited to, citations, editor ships, professional leadership positions and other measures of professional esteem.

Research limitations/implications
– The implications of the 2013 AACSB accreditation standards for deans are potentially less positive. The new standards codify one of the deans’ major duties – that of ensuring that the faculty have resources adequate to support the school’s mission.

Originality/value
– This paper represents a starting point for understanding the implications of the 2013 AACSB accreditation standards, and that as the standards are operationalized over the subsequent years that these standards, like the previous changes in AACSB standards, will stimulate additional research on business school accreditation. The implications for both faculty and deans are speculative, but are grounded both by the literature and experience of the authors. The paper uses a set of tables to illustrate the impact of the new AACSB standards with examples for each guiding principle and standard.
Health LEADS Australia and implications for medical leadership
Authors: Sebastian Andi , Fulop Liz , Dadich Ann , Fitzgerald Anneke , Kippist Louise , Smyth Anne 
Published: November 2014

Purpose
– The purpose of this paper is to call for strong medical co-leadership in transforming the Australian health system. The paper discusses how Health LEADS Australia, the Australian health leadership framework, offers an opportunity to engage medical clinicians and doctors in the leadership of health services.

Design/methodology/approach
– The paper first discusses the nature of medical leadership and its associated challenges. The paper argues that medical leaders have a key role in the design, implementation and evaluation of healthcare reforms, and in translating these reforms for their colleagues. Second, this paper describes the origins and nature of Health LEADS Australia. Third, this paper discusses the importance of the goal of Health LEADS Australia and suggests the evidence-base underpinning the five foci in shaping medical leadership education and professional development. This paper concludes with suggestions on how Health LEADS Australia might be evaluated.

Findings
– For the well-being of the Australian health system, doctors need to play an important role in the kind of leadership that makes measurable differences in the retention of clinical professions; improves organisational cultures; enhances the engagement of consumers and their careers; is associated with better patient and public health outcomes; effectively addresses health inequalities; balances cost effectiveness with improved quality and safety; and is sustainable.

Originality/value
– This is the first article addressing Health LEADS Australia and medical leadership. Australia is actively engaging in a national approach to health leadership. Discussions about the mechanisms and intentions of this are valuable in both national and global health leadership discourses.
Embedding physician leadership development within health organizations
Authors: Snell Anita Joanne , Eagle Chris , Van Aerde John Emile 
Published: November 2014

Purpose
– The purpose of this conceptual paper is to provide strategies on how to embed physician leadership development efforts within health organizations.

Design/methodology/approach
– Findings from our previous research, which include an extensive literature review and analysis of 53 interviews with representatives from healthcare organizations across the globe, are integrated within the context of the Influencer© framework to provide a useful and grounded tool for physician leadership development strategies.

Findings
– Physician leadership development strategies are identified for each of the six domains within the Influencer© framework.

Practical implications
– A number of physician leadership development strategies are provided. They can be used in combination or used independently.

Originality/value
– Integrating the knowledge gained from practices in health organizations and from the literature within the Influencer© framework is a unique approach and strengthens the usefulness of the identified physician leadership development strategies.
Numerical estimation of carbonate rock properties using multiscale images
Authors: Jouini Mohamed Soufiane , Vega Sandra , Al‐Ratrout Ahmed 
Published: November 2014

ABSTRACTCharacterizing the pore space of rock samples using three‐dimensional (3D) X‐ray computed tomography images is a crucial step in digital rock physics. Indeed, the quality of the pore network extracted has a high impact on the prediction of rock properties such as porosity, permeability and elastic moduli. In carbonate rocks, it is usually very difficult to find a single image resolution which fully captures the sample pore network because of the heterogeneities existing at different scales. Hence, to overcome this limitation a multiscale analysis of the pore space may be needed. In this paper, we present a method to estimate porosity and elastic properties of clean carbonate (without clay content) samples from 3D X‐ray microtomography images at multiple resolutions. We perform a three‐phase segmentation to separate grains, pores and unresolved porous phase using 19 μm resolution images of each core plug. Then, we use images with higher resolution (between 0.3 and 2 μm) of microplugs extracted from the core plug samples. These subsets of images are assumed to be representative of the unresolved phase. We estimate the porosity and elastic properties of each sample by extrapolating the microplug properties to the whole unresolved phase. In addition, we compute the absolute permeability using the lattice Boltzmann method on the microplug images due to the low resolution of the core plug images.In order to validate the results of the numerical simulations, we compare our results with available laboratory measurements at the core plug scale. Porosity average simulations for the eight samples agree within 13%. Permeability numerical predictions provide realistic values in the range of experimental data but with a higher relative error. Finally, elastic moduli show the highest disagreements, with simulation error values exceeding 150% for three samples.
Albumin Leakage in Online Hemodiafiltration, More Convective Transport, More Losses?
Authors: Vega Almudena , Quiroga Borja , Abad Soraya , Aragoncillo Inés , Arroyo David , Panizo Nayara , López‐Gómez Juan M. 
Published: November 2014

AbstractOnline hemodiafiltration (OL‐HDF) has now demonstrated some benefits in reducing mortality. It seems that rising convective volumes improve the outcomes, but the risks of it, such as albumin leakage, are not well defined yet. The aim of the present study was to evaluate the albumin leakage using two different filters with 20 and 30 L of post‐dilution OL‐HDF. In this cross‐sectional study, 20 prevalent patients receiving post‐dilution OL‐HDL were included. We analyzed two dialyzers: FX1000, FMC and Polyflux 210H, Gambro. During four consecutive dialysis sessions, monitors were programmed using control‐volume to obtain 20 or 30 L with both dialyzers. We collected albumin samples of the effluent at 5, 15, 30, 45 and 60 min and performed area under the curve (AUC) determinations for evaluating the losses. Mean patient age was 60 ± 9 years, and 70% were men. Albumin leakage was significant higher with Polyflux 210H when compared to FX 1000 FMC. A convective volume of 30 L produced greater albumin leakage than 20 L with both filters, though only with the FX 1000 FMC was it significant (minimum albumin leakage during first hour with FX 1000 FMC 20 L: 79.2 [0.0–175.7] mg; 30 liters: 403.3 [63.5–960.7] mg; with PF 210 Gambro 20 L: 869.1 [420.0–3214.7] mg; 30 L: 1841.7 [443.8–3417.5] mg). During OL‐HDF, convective transport causes albumin leakage at least during the first hour. The albumin concentration in the effluent differs according to the type of filter used and the convective volume.
Effect of nutrient application and water turbidity on submergence tolerance of rice (Oryza sativa)
Authors: Gautam P. , Lal B. , Raja R. , Baig M.J. , Mohanty S. , Tripathi R. , Shahid M. , Bhattacharyya P. , Nayak A.K. 
Published: November 2014

AbstractFlooding imposes severe selection pressure on plants, principally because excess water in their surroundings deprives the plants from certain basic resources such as oxygen, carbon dioxide and light for photosynthesis. Here, the effects of nitrogen and phosphorus application and their application time, on four Indica rice cultivars and their tolerance to submergence under turbid and clear flood water was studied. Submergence tolerance on metabolic changes, photosynthetic (Pn) rate and ethylene accumulation were evaluated. Submergence substantially reduced survival, chlorophyll, soluble sugars, Pn rate across cultivars with drastic reduction in IR‐20. Sub1 cultivars showed greater Pn rate as compared to sensitive cultivar under submergence because of better protection of chlorophyll, more stomatal conductance leading to higher survival. Turbid water resulted in lower under‐water photosynthesis because of poor light transmission, chlorophyll retention and silt deposition and ultimately poor survival. Foliar spray of N after desubmergence along with basal P improved the chlorophyll, soluble sugars and Pn rate and extenuated ethylene accumulation and shoot elongation resulting in significantly higher survival. To the best of our knowledge, this is the first time that such a study has been performed. Crop establishment could therefore be enhanced in areas where untimely flooding is anticipated by applying basal P and foliar spray of post‐submergence N.
Scandinavian clinical practice guideline on choice of fluid in resuscitation of critically ill patients with acute circulatory failure
Authors: PERNER A. , JUNTTILA E. , HANEY M. , HREINSSON K. , KVÅLE R. , VANDVIK P. O. , MØLLER M. H. 
Published: November 2014

BackgroundThe task force on Acute Circulatory Failure of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine produced this guideline with recommendations concerning the use of crystalloid vs. colloid solutions in adult critically ill patients with acute circulatory failure.MethodsGrading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to grade the quality of evidence and to determine the strengths of the recommendations. As efficacy and harm may vary in different subpopulations of patients with acute circulatory failure, we produced recommendations for general intensive care unit (ICU) patients and those with sepsis, trauma and burn injury.ResultsFor general ICU patients and those with sepsis, we recommend using crystalloids for resuscitation rather than hydroxyethyl starch and we suggest using crystalloids rather than gelatin and albumin. For patients with trauma we recommend to use crystalloids for resuscitation rather than colloid solutions. For patients with burn injury we provide no recommendations as there are very limited data from randomised trials on fluid resuscitation in this patient population.ConclusionsWe recommend using crystalloid solutions rather than colloid solutions for resuscitation in the majority of critically ill patients with acute circulatory failure.
Localization of sunitinib, its metabolites and its target receptors in tumour‐bearing mice: a MALDI‐MS imaging study
Authors: Torok S , Vegvari A , Rezeli M , Fehniger T E , Tovari J , Paku S , Laszlo V , Hegedus B , Rozsas A , Dome B , Marko‐Varga G 
Published: November 2014

Background and PurposeThe clinical effects of anti‐angiogenic agents remain controversial. Therefore, elucidating the pharmacological properties of these compounds is a pivotal issue.Experimental ApproachThe effects of treatment with sunitinib on tumour and normal tissues of mice bearing C‐26 adenocarcinoma cells were analysed by matrix‐assisted laser desorption ionization MS imaging (MALDI‐MSI). Expression of the key targets of sunitinib – angiogenic receptors – was studied by immunofluorescent labelling.Key ResultsMALDI‐MS assays showed that sunitinib and its fragment ions were present throughout tumour and normal tissues. Major metabolites were identified in blood and solid tissues, while minor drug metabolites were detectable only in blood. Tumour growth and intratumour VEGF receptor‐2 expressions were significantly reduced in sunitinib‐treated mice, while the expression of the other targeted receptors, PDGF receptor ‐α or ‐β and fibroblast growth factor receptor‐1, remained unaffected. Within tumour tissue, the close proximity of sunitinib metabolites to the precursor ion suggested in situ metabolism of the administered drug. There were intratumour areas where the signal intensity of sunitinib correlated with expression of VEGF receptor‐2.Conclusions and ImplicationsThis is the first study that demonstrates MALDI‐MSI is a versatile platform to study the intratumour localization of an unlabelled anti‐angiogenic drug. The combination of MALDI‐MSI and immunofluorescence analysis can provide further insights into the molecular interaction of drug compounds and their targets within tumour tissue.
Regulator of G‐protein signalling 5 protects against atherosclerosis in apolipoprotein E‐deficient mice
Authors: Cheng Wen‐Lin , Wang Pi‐Xiao , Wang Tao , Zhang Yan , Du Cheng , Li Hongliang , Ji Yong 
Published: November 2014

Background and PurposeAtherosclerosis is a chronic inflammatory disease, in which ‘vulnerable plaques’ have been recognized as the underlying risk factor for coronary disease. Regulator of G‐protein signalling (RGS) 5 controls endothelial cell function and inflammation. In this study, we explored the effect of RGS5 on atherosclerosis and the potential underlying mechanisms.Experimental ApproachRGS5−/− apolipoprotein E (ApoE)−/− and ApoE−/− littermates were fed a high‐fat diet for 28 weeks. Total aorta surface and lipid accumulation were measured by Oil Red O staining and haematoxylin–eosin staining was used to analyse the morphology of atherosclerotic lesions. Inflammatory cell infiltration and general inflammatory mediators were examined by immunofluorescence staining. Apoptotic endothelial cells and macrophages were assayed with TUNEL. Expression of RGS5and adhesion molecules, and ERK1/2 phosphorylation were evaluated by co‐staining with CD31. Expression of mRNA and protein were determined by quantitative real‐time PCR and Western blotting respectively.Key ResultsAtherosclerotic phenotypes were significantly accelerated in RGS5−/−ApoE−/− mice, as indicated by increased inflammatory mediator expression and apoptosis of endothelial cells and macrophages. RGS5 deficiency enhanced instability of vulnerable plaques by increasing infiltration of macrophages in parallel with the accumulation of lipids, and decreased smooth muscle cell and collagen content. Mechanistically, increased activation of NF‐κB and MAPK/ERK 1/2 could be responsible for the accelerated development of atherosclerosis in RGS5‐deficient mice.Conclusions and ImplicationsRGS5 deletion accelerated development of atherosclerosis and decreased the stability of atherosclerotic plaques partly through activating NF‐κB and the MEK‐ERK1/2 signalling pathways.Linked ArticlesThis article is part of a themed section on Chinese Innovation in Cardiovascular Drug Discovery. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-23
FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF‐1α activation
Authors: El Assar M , Sánchez‐Puelles J M , Royo I , López‐Hernández E , Sánchez‐Ferrer A , Aceña J L , Rodríguez‐Mañas L , Angulo J 
Published: November 2014

Background and PurposeFM19G11 up‐regulates mammalian target of rapamycin (mTOR)/hypoxia inducible factor‐1α (HIF‐1α) and PI3K/Akt pathways, which are involved in endothelial function. We evaluated the effects of FM19G11 on defective endothelial vasodilatation in arteries from rats and humans and investigated the mechanisms involved.Experimental ApproachEffects of chronic in vivo administration of FM19G11 on aortic endothelial vasodilatation were evaluated together with ex vivo treatment in aortic and mesenteric arteries from control and insulin‐resistant rats (IRR). Its effects on vasodilator responses of penile arteries (HPRAs) and corpus cavernosum (HCC) from men with vasculogenic erectile dysfunction (ED) (model of human endothelial dysfunction) were also evaluated. Vascular expression of phosphorylated‐endothelial NOS (p‐eNOS), phosphorylated‐Akt (p‐Akt) and HIF‐1α was determined by immunodetection and cGMP by elisa.Key ResultsChronic administration of FM19G11 reversed the impaired endothelial vasodilatation in IRR. Ex vivo treatment with FM19G11 also significantly improved endothelium‐dependent vasodilatation in aorta and mesenteric arteries from IRR. These effects were accompanied by the restoration of p‐eNOS and cGMP levels in IRR aorta and were prevented by either NOS or PI3K inhibition. p‐Akt and p‐eNOS contents were increased by FM19G11 in aortic endothelium of IRR. FM19G11‐induced restoration of endothelial vasodilatation was unaffected by mTOR/HIF‐1α inhibitors. FM19G11 also restored endothelial vasodilatation in HPRA and HCC from ED patients.Conclusions and ImplicationsStimulation of the PI3K/Akt/eNOS pathway by FM19G11 alleviates impaired NO‐mediated endothelial vasodilatation in rat and human arteries independently of mTOR/HIF‐1α activation. This pharmacological strategy could be beneficial for managing pathological conditions associated with endothelial dysfunction, such as ED.
AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation
Authors: Feuerbach Dominik , Pezous Nicole , Weiss Markus , Shakeri‐Nejad Kasra , Lingenhoehl Kurt , Hoyer Daniel , Hurth Konstanze , Bilbe Graeme , Pryce Christopher R , McAllister Kevin , Chaperon Frederique , Kucher Klaus , Johns Donald , Blaettler Thomas , Lopez Lopez Cristina 
Published: November 2014

Background and PurposeActivation of the α7 nicotinic ACh receptor (nACh receptor) is considered an attractive target for the treatment of cognitive impairment associated with neurological disorders. Here we describe the novel α7‐nACh receptor agonist AQW051 as a promising drug candidate for this indication.Experimental ApproachAQW051 was functionally characterized in vitro and cognitive effects evaluated in rodent behavioural models. Pharmacokinetics and tolerability were evaluated in three phase I placebo‐controlled studies in 180 healthy subjects.Key ResultsIn vitro, AQW051 bound with high affinity to α7‐nACh receptors and stimulated calcium influx in cells recombinantly expressing the human α7‐nACh receptor. In vivo, AQW051 demonstrated good oral bioavailability and rapid penetration into the rodent brain. AQW051 administered over a broad dose range facilitated learning/memory performance in the object recognition and social recognition test in mice and the water maze model in aged rats. Clinically, AQW051 was well tolerated in healthy young and elderly subjects, with an adverse event (AE) profile comparable with placebo. No serious AEs were reported and all AEs were either mild or moderate in severity at single oral doses up to 200 mg and multiple daily doses up to 75 mg. Once‐daily oral administration of AQW051 resulted in continuous exposure and a two‐ to threefold accumulation compared with steady state was achieved by 1 week.Conclusions and ImplicationsThese data support further development of AQW051 as a cognitive‐enhancing agent, as a therapeutic, for example, in Alzheimer's disease or schizophrenia.
Genistein alleviates pressure overload‐induced cardiac dysfunction and interstitial fibrosis in mice
Authors: Qin Wei , Du Ning , Zhang Longyin , Wu Xianxian , Hu Yingying , Li Xiaoguang , Shen Nannan , Li Yang , Yang Baofeng , Xu Chaoqian , Fang Zhiwei , Lu Yanjie , Zhang Yong , Du Zhimin 
Published: November 2014

Background and PurposePressure overload‐induced cardiac interstitial fibrosis is viewed as a major cause of heart failure in patients with hypertension or aorta atherosclerosis. The purpose of this study was to investigate the effects and the underlying mechanisms of genistein, a natural phytoestrogen found in soy bean extract, on pressure overload‐induced cardiac fibrosis.Experimental ApproachGenisten was administered to mice with pressure overload induced by transverse aortic constriction. Eight weeks later, its effects on cardiac dysfunction, hypertrophy and fibrosis were determined. Its effects on proliferation, collagen production and myofibroblast transformation of cardiac fibroblasts (CFs) and the signalling pathways were also assessed in vitro.Key ResultsPressure overload‐induced cardiac dysfunction, hypertrophy and fibrosis were markedly attenuated by genistein. In cultured CFs, genistein inhibited TGFβ1‐induced proliferation, collagen production and myofibroblast transformation. Genistein suppressed TGFβ‐activated kinase 1 (TAK1) expression and produced anti‐fibrotic effects by blocking the TAK1/MKK4/JNK pathway. Further analysis indicated that it up‐regulated oestrogen‐dependent expression of metastasis‐associated gene 3 (MTA3), which was found to be a negative regulator of TAK1. Silencing MTA3 by siRNA, or inhibiting the activity of the MTA3‐NuRD complex with trichostatin A, abolished genistein's anti‐fibrotic effects.Conclusions and ImplicationsGenistein improved cardiac function and inhibited cardiac fibrosis in response to pressure overload. The underlying mechanism may involve regulation of the MTA3/TAK1/MKK4/JNK signalling pathway. Genistein may have potential as a novel agent for prevention and therapy of cardiac disorders associated with fibrosis.Linked ArticlesThis article is part of a themed section on Chinese Innovation in Cardiovascular Drug Discovery. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-23