bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Multistereogenic Phosphine Ligand‐Promoted Palladium‐Catalyzed Allylic Alkylation of Cyanoesters.
Authors: Deng Wen‐Hui , Ye Fei , Bai Xing‐Feng , Zheng Zhan‐Jiang , Cui Yu‐Ming , Xu Li‐Wen 
Published: May 2015

AbstractThe presented asymmetric title reaction provides the products as mixtures of two diastereomers, each of which is formed with moderate to high enantiomeric excess (63‐96% ee).
ChemInform Abstract: Organocatalytic Enantio‐ and Diastereoselective Synthesis of 1,2‐Dihydronaphthalenes from Isobenzopyrylium Ions.
Authors: Qian Hui , Zhao Wanxiang , Wang Zhaobin , Sun Jianwei 
Published: May 2015

AbstractThe title reaction is a new catalytic asymmetric synthesis of important dihydronaphthalenes, and also a new example of asymmetric reactions of the versatile isobenzopyrylium species.
ChemInform Abstract: Palladium‐Mediated α‐Arylation of β‐Ketosulfones: Application to the Synthesis of Functionalized Sulfonyl Phenanthrenes.
Authors: Chang Meng‐Yang , Chen Yi‐Chia , Chan Chieh‐Kai 
Published: May 2015

AbstractA great variety of sulfonyl phenanthrenes (V) is prepared via O‐alkylation of skeleton (III) followed by photo‐induced Scholl ring‐closure.
ChemInform Abstract: Synthesis of Pyranocoumarin Fused Spirooxindoles via Knoevenagel/Michael/Cyclization Sequence: A Regioselective Organocatalyzed Multicomponent Reaction.
Authors: Pal Suman , Khan Md. Nasim , Karamthulla Shaik , Choudhury Lokman H. 
Published: May 2015

AbstractThe three component reaction of isatins, chromenone (III), and malononitrile in methanol affords the title compounds (IV).
ChemInform Abstract: Enantiotopos‐Selective C—H Oxygenation Catalyzed by a Supramolecular Ruthenium Complex.
Authors: Frost James R. , Huber Stefan M. , Breitenlechner Stefan , Bannwarth Christoph , Bach Thorsten 
Published: May 2015

AbstractSpirocyclic oxindoles undergo an enantioselective oxygenation reaction (nine examples; e.r.
ChemInform Abstract: Palladium/Norbornene Chemistry: An Unexpected Route to Methanocarbazole Derivatives via Three Csp3—Csp2/Csp3—N/Csp 2—N Bond Formations in a Single Synthetic Sequence.
Authors: Jafarpour Farnaz , Jalalimanesh Nafiseh , Teimouri Mahdieh , Shamsianpour Mitra 
Published: May 2015

AbstractThe formation of methanocarbazoles is carried out by chemo‐ and regioselective annulation via Catellani cascade reaction including Heck reaction, C—H activation, and amination.
ChemInform Abstract: Oxidative Coupling of Alkenes with Aldehydes and Hydroperoxides: One‐Pot Synthesis of 2,3‐Epoxy Ketones.
Authors: Wei Wen‐Ting , Yang Xu‐Heng , Li Hai‐Bing , Li Jin‐Heng 
Published: May 2015

Abstract2,3‐Epoxy ketones [(III) and (V)] are synthesized through an oxidative radical pathway with a broad substrate scope and excellent selectivity control.
ChemInform Abstract: Metal‐Free Radical 5‐exo‐Dig Cyclizations of Phenol‐Linked 1,6‐Enynes for the Synthesis of Carbonylated Benzofurans.
Authors: Hu Ming , Song Ren‐Jie , Li Jin‐Heng 
Published: May 2015

AbstractA new metal‐free radical 5‐exo‐dig cyclization of phenol‐linked 1,6‐enynes with O2, TEMPO and tBuONO is described.
ChemInform Abstract: Three‐Component Synthesis of New Substituted Bis[2‐imino‐3‐(substituted)‐4‐phenyl‐3H‐thiazole] Derivatives and Evaluation of Their Antibacterial Activity.
Authors: Yahyazadeh Asieh , Abbasi Shiran Jafar , Yamin Bohari M. , Mamaghani Manouchehr , Kiyani Hamzeh 
Published: May 2015

AbstractThe antimicrobial activity of the synthesized compounds are evaluated against Salmonella enterica, Micrococcus luteus, Bacillus subtilis, and Pseudomonas aeruginosa.
ChemInform Abstract: Ruthenium‐Catalyzed C—H Activation of Thioxanthones.
Authors: Wagner Danny , Braese Stefan 
Published: May 2015

AbstractThioxanthones readily synthesized in one step from thiosalicylic acid and arenes are used in ruthenium‐catalyzed C—H‐activation reaction to produce substituted thioxanthones in good to excellent yields.
ChemInform Abstract: Chemoselective Suzuki‐Cross Coupling Reactions of 5‐Bromoquinolin‐8‐yl Trifluoromethanesulfonate.
Authors: Khaddour Zien , Akrawi Omer A. , Hamdy Aws M. , Suleiman Ali , Jamous Kinan , Villinger Alexander , Langer Peter 
Published: May 2015

AbstractThe title reaction proceeds with very good chemoselectivity in favour of the bromide substituent to give 5‐mono‐arylated or 5,8‐bis‐arylated quinolines.
ChemInform Abstract: Ligand‐Controlled Regiodivergent Nickel‐Catalyzed Annulation of Pyridones.
Authors: Donets Pavel A. , Cramer Nicolai 
Published: May 2015

AbstractA nickel‐catalyzed C—H functionalization of 2‐pyridones and subsequent cyclization affords 1,6‐annulated 2‐pyridones by selective intramolecular olefin hydroarylation.
ChemInform Abstract: Isoquinolino[4,3,2‐de]phenanthridine: Synthesis and Its Use in 1,3‐Dipolar Cycloadditions to Form Nitrogen‐Containing Polyaromatic Hydrocarbons.
Authors: Ito S. , Tokimaru Y. , Nozaki K. 
Published: May 2015

AbstractThe new synthesis of the intermediate isoquinolino[4,3,2‐de]phenanthridine is achieved by treatment of the compound (V) with Et3N.
ChemInform Abstract: Polyphosphoric Acid Catalyst for the One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones by Grinding under Solvent‐Free Conditions.
Authors: Zhao Ying , Zhao Yongguang , Zhang Jianping , Liu Hongmei , Liang Liman 
Published: May 2015

AbstractPPA is found to be an efficient catalyst for the synthesis of pyrimidinones (IV) via the Biginelli reaction.
ChemInform Abstract: Rhodium(II)‐Catalyzed Transannulation of 1‐Sulfonyl‐1,2,3‐triazoles with 2H‐Azirines: A New Method to Dihydropyrazines.
Authors: Ding Haixin , Hong Sanguo , Zhang Ning 
Published: May 2015

AbstractThe dihydropyrazine products can be deprotected under basic conditions to give pyrazines as shown in case of product (IIIa).
ChemInform Abstract: Synthesis of New 3‐Phenyl Substituted Dibenzo‐1,4‐diazepin‐1‐one Derivatives.
Authors: Wang Fang‐Ming , Bao Dan , Wang Ming , Li Ming‐Jun , Chen Li‐Zhuang , Han Guang‐Fan 
Published: May 2015

Abstractvia condensation of dione (I) with o‐phenylenediamine (II), and various benzaldehydes
ChemInform Abstract: Iminopyridine Oxazoline Iron Catalyst for Asymmetric Hydroboration of 1,1‐Disubtituted Aryl Alkenes.
Authors: Chen Jianhui , Xi Tuo , Lu Zhan 
Published: May 2015

AbstractHighly regio‐ and enantioselective anti‐Markovnikov hydroboration of 1,1‐disubstituted aryl alkenes (I) is achieved using a novel chiral iminopyridine oxazoline ligand.
ChemInform Abstract: Site‐Selective C(sp3)—H Functionalization of Di‐, Tri‐, and Tetrapeptides at the N‐Terminus.
Authors: Gong Wei , Zhang Guofu , Liu Tao , Giri Ramesh , Yu Jin‐Quan 
Published: May 2015

AbstractN‐terminal alanine peptides are regioselectively arylated and acetoxylated in the presence of Palladium(II) acetate.
ChemInform Abstract: A Practical Aryl Unit for Azlactone Dynamic Kinetic Resolution: Orthogonally Protected Products and a Ligation‐Inspired Coupling Process.
Authors: Tallon Sean , Manoni Francesco , Connon Stephen J. 
Published: May 2015

AbstractThe first enantioselective azlactone dynamic kinetic resolution to generate orthogonally protected amino acids is developed.
ChemInform Abstract: Total Synthesis and Structure Elucidation of (.+‐.)‐Triumphalone and (.+‐.)‐Isotriumphalone.
Authors: Nishimura Eiji , Ohfune Yasufumi , Shinada Tetsuro 
Published: May 2015

AbstractThe first total synthesis of (.+‐.)‐triumphalone (I) and its conversion to (.+‐.)‐isotriumphalone is presented resulting in a revision of the reported structure.
Asymmetric Borane Reduction of Prochiral Ketones Catalyzed By Helical Poly[(S)‐3‐vinyl‐2,2'‐dihydroxy‐1,1'‐binaphthyl]
Authors: Qin Guochang , Chen Yehui , Yang Liwen , Yang Nianfa , Yang Zhusheng 
Published: May 2015

AbstractThe application of helical poly[(S)‐3‐vinyl‐2,2'‐dihydroxy‐1, 1'‐binaphthyl] (L*) in the asymmetric borane reduction of prochiral ketones was studied. The results showed that L* had excellent catalytic activity as well as enantioselectivity, giving up to 96% yield and up to 99% enantiomeric excess (ee) of the corresponding secondary alcohol at 25 °C. Moreover, L* can be easily recovered and reused without loss of catalytic activity. Chirality 27:422–424, 2015. © 2015 Wiley Periodicals, Inc.
Theoretical Electronic Circular Dichroism Study of 1,3‐Diene Derivatives for the Elucidation of ECD Spectra of 1,3‐Cyclohexadiene and Its Derivatives
Authors: Nakayama Naofumi , Goto Hitoshi 
Published: May 2015

AbstractThe origin of P‐ or M‐chirality of methyl substituted 1,3‐cyclohexadienes are elucidated by time‐dependent density functional theory (TD‐DFT) calculation of 1,3‐cyclohexadiene derivatives and acyclic 1,3‐dienes. The sign‐inversion of the rotatory strength of the lowest excited state between 1,3‐cyclohexadiene and (5R)‐axial‐methyl‐1,3‐cyclohexadiene is caused by the conformation around the (C=)C‐C(‐Me) dihedral angle. The correlation between the sign of the rotatory strength and conformation has been found not only in methyl substituted derivatives but also fluoro substituted compounds. Chirality 27:476–478, 2015. © 2015 Wiley Periodicals, Inc.
Funding conditions for aid effectiveness: A mixed blessing for the sustainable development of host‐country‐national employees
Authors: O'Sullivan Sharon L. 
Published: May 2015

AbstractThis paper explores whether—and how—aid effectiveness funding conditions impact the human resource development of host‐country national (HCN) employees. To investigate this relationship, I conducted a phenomenological study with 31 participants from three international nongovernmental organizations (INGOs). Results suggest that the pressure toward funds accountability brings mixed blessings: From a staffing perspective, more HCNs are being hired instead of expatriates, building local capacity. However, vital training and performance review functions are cast as inefficient overheads. The paper concludes with a conceptual framework, practical strategies for INGOs and donor governments, and directions for larger scale empirical research. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
Cervical cancer screening and follow‐up in 4 geographically diverse US health care systems, 1998 through 2007
Authors: Weinmann Sheila , Williams Andrew E. , Kamineni Aruna , Buist Diana S.M. , Masterson Erin E. , Stout Natasha K. , Stark Azadeh , Ross Tyler R. , Owens Christopher L. , Field Terry S. , Doubeni Chyke A. 
Published: May 2015

BACKGROUNDCervical cancer screening and follow‐up guidelines have changed considerably in recent years, but to the authors' knowledge few published reports exist to estimate the impact of these changes in community‐based settings. The authors examined the patterns and results of cervical cancer testing and follow‐up over a decade in 4 geographically diverse US health care systems to inform the future evaluation of changes resulting from increased uptake of the human papillomavirus (HPV) vaccination.METHODSThe authors studied women aged 21 to 65 years who were members of one of these health systems at any time between 1998 and 2007. Data were collected and standardized across sites, based on receipt of Papanicolaou (Pap) and HPV tests, HPV vaccination, cervical biopsies, and treatment of cervical dysplasia. Annual rates (per 1000 person‐years) of Pap testing, HPV testing, and cervical biopsy and treatment procedures were calculated. Screening intervals and trends in the results of screening Pap tests and cervical biopsies also were examined.RESULTSPap testing rates decreased (from 483 per 1000 person‐years in 2000 to 412 per 1000 person‐years in 2007) and HPV testing rates increased over the study period. Screening frequency varied across health care systems, and many women continued to receive annual testing. All 4 sites moved to less frequent screening over the study period without marked changes in the overall use of cervical biopsy or treatment.CONCLUSIONSDespite differences over time and across health plans in rates of cervical cancer testing and follow‐up cervical procedures, the authors found no notable differences in Pap test results, diagnostic or treatment procedure rates, or pathological outcomes. This finding suggests that the longer screening intervals did not lead to more procedures or more cancer diagnoses. Cancer 2015;121:2976–2983. © 2015 American Cancer Society.
Patient‐specific anisotropic model of human trunk based on MR data
Authors: Courchesne Olivier , Guibault Francois , Parent Stefan , Cheriet Farida 
Published: May 2015

SummaryThere are many ways to generate geometrical models for numerical simulation, and most of them start with a segmentation step to extract the boundaries of the regions of interest. This paper presents an algorithm to generate a patient‐specific three‐dimensional geometric model, based on a tetrahedral mesh, without an initial extraction of contours from the volumetric data. Using the information directly available in the data, such as gray levels, we built a metric to drive a mesh adaptation process. The metric is used to specify the size and orientation of the tetrahedral elements everywhere in the mesh. Our method, which produces anisotropic meshes, gives good results with synthetic and real MRI data. The resulting model quality has been evaluated qualitatively and quantitatively by comparing it with an analytical solution and with a segmentation made by an expert. Results show that our method gives, in 90% of the cases, as good or better meshes as a similar isotropic method, based on the accuracy of the volume reconstruction for a given mesh size. Moreover, a comparison of the Hausdorff distances between adapted meshes of both methods and ground‐truth volumes shows that our method decreases reconstruction errors faster. Copyright © 2015 John Wiley & Sons, Ltd.
Structures, Electrochemical and Spectral Properties of a Series of [MnN(CN)3(diimine)]– Complexes
Authors: Murphy Michael J. , Hua Carol , Price Jason R. , D'Alessandro Deanna M. , Kepert Cameron J. 
Published: May 2015

AbstractThe structures and the electrochemical and spectral properties of a series of discrete [PPh4][MnN(CN)3(diimine)] complexes {diimine = 2,2′‐bipyridine [1(bpy)], 4,4′‐dimethyl‐2,2′‐bipyridine [1(4‐dmbpy)], 5,5′‐dimethyl‐2,2′‐bipyridine [1(5‐dmbpy)], 1,10‐phenanthroline [1(phen)] and bipyrimidine [1(bpym)]} have been assessed. These complexes represent potential building blocks for the construction of coordination frameworks. The incorporation of diimine ligands with different π‐accepting capacities allows the systematic tuning of the metal‐to‐ligand charge‐transfer (MLCT) band as well as the MnV/MnVI redox potential. The complexes exhibit solvatochromism, and the marked sensitivity of λmax of the MLCT band to polar solvents leads the way towards their potential application in chemical sensing.
Concise Synthesis of All Stereoisomers of Dendroamide A by Fluorous Mixture Synthesis Based on Fluorous‐Fmoc Protection of Amino Acids
Authors: Takahashi Hiroaki , Endo Natsuki , Takanose Hitomi , Sugiyama Yuya , Eguchi Fumitaka , Oguri Kazuma , Hamamoto Hiromi , Shioiri Takayuki , Matsugi Masato 
Published: May 2015

AbstractA liquid‐phase split‐type synthesis of all the stereoisomers of dendroamide A, which exhibits multidrug‐resistance reversing activity, has been carried out. The key to the concise synthesis was the fluorous‐Fmoc protection strategy of each of the starting materials (D‐ and L‐alanine and D‐ and L‐valine). By using the fluorous‐Fmoc encoding method, the target stereoisomers were effectively synthesized individually in fewer steps than by the corresponding linear synthetic routes.
Implication of microRNA deregulation in the response of vertebrates to endocrine disrupting chemicals
Authors: Cameron Brooke E. , Craig Paul M. , Trudeau Vance L. 
Published: May 2015

Abstract

Micro ribonucleic acids (miRNAs) are recently discovered small regulatory molecules that control messenger RNA (mRNA) translation in plants and animals and have been implicated in a variety of hormone-related physiological pathways. Estrogens, thyroid hormones, and gonadotropins are all known to act on miRNA abundance to cause major shifts in cellular activity, physiology, and homeostatic control mechanisms. Research on cancer biology has also recently considered miRNA as therapeutic targets, because the deregulation of specific miRNAs in various tissues has been correlated with tumorigenesis and other carcinogenic responses. Because many pharmaceuticals are considered to be endocrine-disrupting chemicals (EDCs), their effects on miRNAs may be important to our understanding of basic physiological control and phenotypic outcomes of wildlife exposed to EDCs. Presented is a brief overview of the synthesis, control, and action of miRNAs, focusing on endocrine systems. The antidepressant fluoxetine will be used as an example for miRNA studies in aquatic species, one of the few examples in ecotoxicology. Given the mounting evidence that miRNAs are regulated by hormones, a clear need exists to investigate the potential for environmental EDCs to deregulate miRNA expression and action. Environ Toxicol Chem 2016;35:788–793. © 2015 SETAC
Using molecular biomarkers and traditional morphometric measurements to assess the health of slimy sculpin (Cottus cognatus) from streams with elevated selenium in North-Eastern British Columbia
Authors: Miller Lana L. , Isaacs Meghan A. , Martyniuk Christopher J. , Munkittrick Kelly R. 
Published: May 2015

Abstract

Canadian fish-based environmental effects monitoring programs use individual and population-level endpoints to assess aquatic health. Impacts of coal mining and selenium (Se) exposure were assessed in slimy sculpin (Cottus cognatus) from reference streams located both inside and outside of a coal zone, and from 1 stream with a history of coal mining, using traditional environmental effects monitoring endpoints. In addition, physical characteristics of the streams and benthic macro-invertebrate communities were assessed. To determine whether the assessment of effects could be improved by including molecular markers, real-time polymerase chain reaction assays were optimized for genes associated with reproduction (vtg, esr1, star, cyp19a1, and gys2), and oxidative and cellular stress (sod1, gpx, gsr, cat, and hsp 90). Water Se levels exceeded guidelines in the stream with historical mining (4 μg/L), but benthic macroinvertebrates did not exceed dietary thresholds (2–3 μg/g dry wt). Whole-body Se levels were above British Columbia's tissue guideline in fish from all streams, but only above the draft US Environmental Protection Agency (USEPA) criterion (7.91 μg/g dry wt) at the reference stream inside the coal zone. Some markers of cellular and oxidative stress were elevated in fish liver at the exposed site (sod1, gpx), but some were lower (cat, sod1, gpx, gsr, hsp90) in the gonads of fish inside the coal zone. Some of the differences in gene expression levels between the reference and impacted sites were sex dependent. Based on benthic macroinvertebrate assessments, the authors hypothesize that traditional and molecular differences in slimy sculpin at impacted sites may be driven by food availability rather than Se exposure. The present study is the first to adapt molecular endpoints in the slimy sculpin for aquatic health assessments. Environ Toxicol Chem 2015;34:2335–2346. © 2015 SETAC
The Effects of Parental Health Shocks on Adult Offspring Smoking Behavior and Self‐Assessed Health
Authors: Darden Michael , Gilleskie Donna 
Published: May 2015

AbstractAn important avenue for smoking deterrence may be through familial ties if adult smokers respond to parental health shocks. In this paper, we merge the Original Cohort and the Offspring Cohort of the Framingham Heart Study to study how adult offspring smoking behavior and subjective health assessments vary with elder parent smoking behavior and health outcomes. These data allow us to model the smoking behavior of adult offspring over a 30‐year period contemporaneously with parental behaviors and outcomes. We find strong ‘like father, like son’ and ‘like mother, like daughter’ correlations in smoking behavior. We find that adult offspring significantly curtail their own smoking following anownhealth shock; however, we find limited evidence that offspring smoking behavior is sensitive to parent health, with the notable exception that women significantly reduce both their smoking participation and intensity following a smoking‐related cardiovascular event of a parent. We also model the subjective health assessment of adult offspring as a function of parent health, and we find that women report significantly worse health following the smoking‐related death of a parent. Copyright © 2015 John Wiley & Sons, Ltd.
Intracellular calcium levels as screening tool for nanoparticle toxicity
Authors: Meindl Claudia , Kueznik Tatjana , Bösch Martina , Roblegg Eva , Fröhlich Eleonore 
Published: May 2015

AbstractThe use of engineered nano‐sized materials led to revolutionary developments in many industrial applications and in the medical field. These materials, however, also may cause cytotoxicity. In addition to size, surface properties and shape were identified as relevant parameters for cell damage. Cell damage may occur as disruption of membrane integrity, induction of apoptosis and by organelle damage. Generation of oxidative stress may serve as an indicator for cytotoxicity. Effects occurring upon short contact of particles with cells, for instance in the systemic blood circulation, could be identified according to increases of intracellular [Ca2+] levels, which are caused by variety of toxic stimuli. Negatively charged, neutral and positively charged polystyrene particles of different sizes were used to study the role of size and surface properties on viability, membrane disruption, apoptosis, lysosome function, intracellular [Ca2+] levels and generation of oxidative stress. Silica particles served to test this hypothesis. Twenty nm polystyrene particles as well as 12 nm and 40 nm silica particles caused membrane damage and apoptosis with no preference of the surface charge. Only 20 nm plain and amine functionalized polystyrene particles cause oxidative stress and only the plain particles lysosomal damage. A potential role of surface charge was identified for 200 nm polystyrene particles, where only the amidine particles caused lysosomal damage. Increases in intracellular [Ca2+] levels and cytotoxicity after 24 h was often linked but determination of intracellular [Ca2+] levels could serve to characterize further the type of membrane damage. © 2015 The Authors. Journal of Applied Toxicology Published by John Wiley & Sons Ltd.