bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast reconstruction of SMS bSSFP myocardial perfusion images using noise map estimation network (NoiseMapNet): a head-to-head comparison with parallel imaging and iterative reconstruction
Authors: Adam Naledi Lenah , Kowalik Grzegorz , Tyler Andrew , Mooiweer Ronald , Neofytou Alexander Paul , McElroy Sarah , Kunze Karl , Speier Peter , Stäb Daniel , Neji Radhouene , Nazir Muhummad Sohaib , Razavi Reza , Chiribiri Amedeo , Roujol Sébastien 
Published: July 2024

BackgroundSimultaneous multi-slice (SMS) bSSFP imaging enables stress myocardial perfusion imaging with high spatial resolution and increased spatial coverage. Standard parallel imaging techniques (e.g., TGRAPPA) can be used for image reconstruction but result in high noise level. Alternatively, iterative reconstruction techniques based on temporal regularization (ITER) improve image quality but are associated with reduced temporal signal fidelity and long computation time limiting their online use. The aim is to develop an image reconstruction technique for SMS-bSSFP myocardial perfusion imaging combining parallel imaging and image-based denoising using a novel noise map estimation network (NoiseMapNet), which preserves both sharpness and temporal signal profiles and that has low computational cost.MethodsThe proposed reconstruction of SMS images consists of a standard temporal parallel imaging reconstruction (TGRAPPA) with motion correction (MOCO) followed by image denoising using NoiseMapNet. NoiseMapNet is a deep learning network based on a 2D Unet architecture and aims to predict a noise map from an input noisy image, which is then subtracted from the noisy image to generate the denoised image. This approach was evaluated in 17 patients who underwent stress perfusion imaging using a SMS-bSSFP sequence. Images were reconstructed with (a) TGRAPPA with MOCO (thereafter referred to as TGRAPPA), (b) iterative reconstruction with integrated motion compensation (ITER), and (c) proposed NoiseMapNet-based reconstruction. Normalized mean squared error (NMSE) with respect to TGRAPPA, myocardial sharpness, image quality, perceived SNR (pSNR), and number of diagnostic segments were evaluated.ResultsNMSE of NoiseMapNet was lower than using ITER for both myocardium (0.045 ± 0.021 vs. 0.172 ± 0.041, p &lt; 0.001) and left ventricular blood pool (0.025 ± 0.014 vs. 0.069 ± 0.020, p &lt; 0.001). There were no significant differences between all methods for myocardial sharpness (p = 0.77) and number of diagnostic segments (p = 0.36). ITER led to higher image quality than NoiseMapNet/TGRAPPA (2.7 ± 0.4 vs. 1.8 ± 0.4/1.3 ± 0.6, p &lt; 0.001) and higher pSNR than NoiseMapNet/TGRAPPA (3.0 ± 0.0 vs. 2.0 ± 0.0/1.3 ± 0.6, p &lt; 0.001). Importantly, NoiseMapNet yielded higher pSNR (p &lt; 0.001) and image quality (p &lt; 0.008) than TGRAPPA. Computation time of NoiseMapNet was only 20s for one entire dataset.ConclusionNoiseMapNet-based reconstruction enables fast SMS image reconstruction for stress myocardial perfusion imaging while preserving sharpness and temporal signal profiles.
Assessment of land use dynamics and vulnerability to land degradation in coal-mined landscapes of central India: implications for ecorestoration strategies
Authors: Thakur Tarun Kumar , Swamy S. L. , Dutta Joystu , Thakur Anita , Mishra Alka , Sarangi Prakash Kumar , Kumar Amit , Almutairi Bader O. , Kumar Rupesh 
Published: July 2024

Introduction: Anthropogenic disturbances resulting from extensive mining activities in tropical regions pose significant threats to native land use, leading to deforestation, biodiversity loss, climate change impacts, environmental degradation, health risks, landscape fragmentation, compromised ecological security, and societal wellbeing. Monitoring Land Use and Land Cover Change (LULCC) becomes imperative for evaluating the extent and nature of land degradation in mined areas.Methods: This study examined and compared land cover change patterns across three coalmined sites: Sohagpur (Site-I), Jamuna &amp; Kotma (Site-II), Bishrampur (Site-III) in Central India over 3 decades using Landsat satellite imagery from 1994, 2007, and 2022. The Maximum Likelihood (ML) algorithm, within a supervised classification framework, was applied to discern mining impacts on decadal land use shifts.Results and discussion: The analysis revealed that 7.32%–17.61% of forest cover, 5.0%–10% of water bodies, and 3%–5% of agricultural lands were lost due to mining activities, with Site three and Site two experiencing greater losses compared to Site 1. Overall, native land cover diminished by 35% between 1994 and 2022. Indices including Soil Index, Climate Index, Terrain Index, Land Utilization Index, and Vegetation Index were derived to assess land degradation patterns. These indices were integrated using a weighted index model in ArcGIS to generate the Land Degradation Vulnerability Index (LDVI). Vulnerability notably escalated with mining expansion, particularly pronounced at Site 3 (Bishrampur) and lower at Site 1 (Sohagpur). The “extremely vulnerable” class encompassed a substantial area (25%–40%), while the “low vulnerable” class was less than 5% across all sites. This study’s comprehensive analysis aids policymakers, planners, and managers in prioritizing targeted interventions and implementing sustainable land management 175 practices for ecorestoration, aligning with the goal of Zero Net Land Degradation 176 (ZNLD) in coal-mined landscapes.
Precision prognosis of colorectal cancer: a multi-tiered model integrating microsatellite instability genes and clinical parameters
Authors: Wang Yonghong , Liu Ke , He Wanbin , Dan Jie , Zhu Mingjie , Chen Lei , Zhou Wenjie , Li Ming , Li Jiangpeng 
Published: July 2024

BackgroundPrognostic assessment for colorectal cancer (CRC) displays substantial heterogeneity, as reliance solely on traditional TNM staging falls short of achieving precise individualized predictions. The integration of diverse biological information sources holds the potential to enhance prognostic accuracy.ObjectiveTo establish a comprehensive multi-tiered precision prognostic evaluation system for CRC by amalgamating gene expression profiles, clinical characteristics, and tumor microsatellite instability (MSI) status in CRC patients.MethodsWe integrated genomic data, clinical information, and survival follow-up data from 483 CRC patients obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. MSI-related gene modules were identified using differential expression analysis and Weighted Gene Co-expression Network Analysis (WGCNA). Three prognostic models were constructed: MSI-Related Gene Prognostic Model (Model I), Clinical Prognostic Model (Model II), and Integrated Multi-Layered Prognostic Model (Model III) by combining clinical features. Model performance was assessed and compared using Receiver Operating Characteristic (ROC) curves, Kaplan-Meier analysis, and other methods.ResultsSix MSI-related genes were selected for constructing Model I (AUC = 0.724); Model II used two clinical features (AUC = 0.684). Compared to individual models, the integrated Model III exhibited superior performance (AUC = 0.825) and demonstrated good stability in an independent dataset (AUC = 0.767).ConclusionThis study successfully developed and validated a comprehensive multi-tiered precision prognostic assessment model for CRC, providing an effective tool for personalized medical management of CRC.
Effect of elevated depressive symptoms during adolescence on health-related quality of life in young adulthood—a six-year cohort study with repeated exposure measurements
Authors: Wiehn Jascha , Kurth Tobias , Ravens-Sieberer Ulrike , Prugger Christof , Piccininni Marco , Reiss Franziska 
Published: July 2024

ObjectivesDepression is a major contributor of young people's burden of disease. In this study we aim to estimate the effect of elevated depressive symptoms on physical health-related quality of life.DesignWe used self-reported information from the prospective BELLA cohort study, which included adolescents selected from the general population in Germany. The baseline assessment (2003–2006) and the 1-, 2-, and 6-year follow-up waves provide the data basis.ParticipantsThe baseline study population consisted of 1,460 adolescents between the ages of 12 and 17 who, according to their caregivers, did not suffer from depression.VariablesThe primary outcome, as measured by the physical component score (PCS) of the SF-36 at a 6-year follow-up (range: 0–100), is physical health-related quality of life. The exposure of interest is depressive symptoms, as measured by the Center for Epidemiological Studies Depression Scale for Children (CES-DC) at baseline, 1-year follow-up and 2-year follow-ups (range: 0–60). We dichotomized the exposure into subthreshold (≤15) and elevated depressive symptoms (&gt;15). For the main analyses we considered a cumulative index for elevated depressive symptoms across the three time points (range: 0–3). Considered confounders are sex, age, socioeconomic status, migrant background, social support, anxiety symptoms, physical activity, chronic diseases, and sleeping problems.Statistical methodsWe used multiple imputation to account for missing values. Within each imputed dataset, we applied inverse probability weighting (IPW) to estimate the effect of the cumulative index for elevated depressive symptoms at baseline, 1- and 2-year follow-up on physical health-related quality of life at 6-year follow-up. We derived 95% confidence intervals by bootstrapping.ResultsAfter adjusting with IPW, the effect of the cumulative index per one unit increase of elevated depressive symptoms on the physical component score was −1.71 (95% CI: −3.51 to −0.04). The adjusted effect estimates of single exposure of elevated depressive symptoms on physical health-related quality of life were −0.83 (95% CI: −3.69 to 1.87) at baseline, −2.96 (95% CI: −4.94 to −0.52) at 1-year follow-up and −1.32 (95% CI: −3.85 to 1.15) at 2-year follow-up.ConclusionFindings suggest that elevated depressive symptoms during adolescence decrease physical health-related quality of life in young adulthood.
The mediating effect of after-midnight use of digital media devices on the association of internet-related addictive behavior and insomnia in adolescents
Authors: Lederer-Hutsteiner Thomas , Müller Kai W. , Penker Matthias , Stolz Erwin , Greimel Elfriede R. , Freidl Wolfgang 
Published: July 2024

BackgroundThere is evidence that overexposure to digital media devices (DMD) can not only lead to addictive patterns of internet use, but also cause insomnia symptoms. The aim of this cross-sectional study among adolescents is to provide an estimate of the prevalence of sleep impairments and to explore the mediating role of after-midnight use of DMD between internet-related addictive behavior (IRAB) and insomnia.Methods2,712 school students from Styrian schools participated in a population-representative online survey in a supervised school setting in spring 2022. School students were screened using established and validated scales. Data analysis was carried out using multiple imputation, linear multilevel regression and mediation analysis.ResultsPrevalence estimation indicates high proportions of clinically relevant moderate [12.6% (11.3%; 14.1%)] and severe [3.6% (2.9%; 4.4%)] insomnia, with an additional 30.6% (29.0%; 32.2%) at subthreshold level. DMD are typically used after midnight an average of 1.66 (1.58; 1.75) evenings with subsequent school day per school week. Linear multilevel regression analysis shows significant associations for sleep disparities as outcome variable e.g., with generalized anxiety [b = 0.329 (0.287; 0.371)], after-midnight use of DMD [b = 0.470 (0.369; 0.572)] and IRAB [b = 0.131 (0.097; 0.165)]. Mediation analysis shows a mediated proportion of 18.2% (13.0%; 25.0%) of the association of IRAB and insomnia by after-midnight use of DMD [Indirect effect: b = 0.032 (0.023; 0.040), direct effect: b = 0.127 (0.083; 0.170)].ConclusionsAlthough the cross-sectional nature of this study limits causal inference, the results indicate a need for policies, which are already in preparation in Styria as part of a respective action plan.
The Suitability of Several Grasses for the Remediation of Hotspots Affected by Cadmium Contamination
Authors: Korzeniowska Jolanta , Stanislawska-Glubiak Ewa 
Published: July 2024

Areas contaminated with cadmium require remediation because it is a highly toxic element. The aim of this study was to assess the Cd tolerance of four grass species (Poa pratensis, Lolium perenne, Festuca rubra, and Festuca pratensis) and to identify the most useful grass for the phytostabilization of areas with extremely high Cd content in the soil. Additionally, the relationship between grass tolerance to Cd and the glutathione (GSH) content in shoots was examined. Two series of pot experiments were carried out using soil artificially contaminated with Cd. Three levels of contamination were used—30, 60, and 130 mg kg−1 Cd—against a control. The plants were cut down 2 months after sowing. At the Cd1 level, L. perenne showed the highest tolerance to Cd (tolerance index TI = 86), while P. pratensis had the lowest tolerance (TI = 65). At Cd2, the TIs ranged from 52 to 59, indicating a similar tolerance of all species. Cd3 was most harmful to L. perenne (TI = 24), while P. pratensis was the most tolerant (TI = 31). Grassroots accumulated much more Cd than shoots. L. perenne showed the greatest increase in root Cd at each contamination level, followed by F. pratensis and then P. pratensis and F. rubra. It is noteworthy that the tolerance of grasses to Cd3 was related to the GSH content in shoots. P. pratensis and F. rubra increased the GSH content 4.6 and 3.6 times, respectively, while L. perenne and F. pratensis only increased it 2.3 times compared to the control plants.
Serviteurs et subalternes dans La Marche de Radetzky de Joseph Roth
Authors: Le Née Aurélie 
Published: July 2024

Diener und Untergeordnete in Roths Radetzkymarsch.
Roths Roman Radetzkymarsch spiegelt die Gesellschaft der Donaumonarchie und deren streng hierarchische Struktur wider. In dieser Gesellschaft ist jedes Individuum der Untergebene eines anderen, und an der Spitze der Pyramide steht der Kaiser. In diesem Zusammenhang werden hier die Figuren der Diener und Untergeordneten untersucht, wobei in einem ersten Teil deren Typologie dargestellt wird und in einem zweiten Teil der Bezug zwischen strenger sozialer Ordnung und Untergang der Habsburger Monarchie hervorgehoben wird. Die treuen Diener Jacques und Onufrij, Slama und Fräulein Hirschwitz, die beide als Untergebener und Hausdame verachtet werden, aber auch der Bezirkshauptmann von Trotta, die Verkörperung des fleißigen Beamten, oder die Franz-Joseph, dem „Allerhöchsten Kriegsherrn“, untergeordnete Armee, als Gruppe oder aus Individuen bestehend, stehen im Mittelpunkt von vorliegendem Beitrag.
Et si nous parlions des femmes ? L’image et le rôle des figures féminines dans La Marche de Radetzky : de la valse à la marche funèbre
Authors: Tunner Erika 
Published: July 2024

From Waltz to Funeral March : Image and Role of Feminine Figures in Joseph Roth’s Radetzky March.
The image of a man, emperor Francis Joseph, plays a dominant role in the novel, whereas the image of the empress remains vaguely outlined and seems to symbolize the gradual decline of the Monarchy. On the contrary, the three women with whom lieutenant Carl Joseph von Trotta engages a relationship, are by no means secondary : Katharina Luise Slama (“Kathi”) and Valerie von Taussig (“Wally”) are both motherly and self-assured figures, whereas Eva Demant embodies the “femme fatale”. The three of them have realistic and allegorical traits. They all try, with no real success, to free themselves from a false moral code, that dominates a crumbling world demanding an inevitable revival.
Die Leiche im Keller. Les écrivains face au passé nazi de l'Autriche
Authors: Lajarrige Jacques 
Published: July 2024

Die Leiche im Keller. Österreichs Schriftsteller und die NS-Vergangenheit.
In den heftigen Auseinandersetzungen um die NS-Vergangenheit Kurt Waldheims nimmt die 1988 von Milo Dor herausgegebene Anthologie Die Leiche im Keller einen besonderen Platz ein, insofern als sie eine breite Palette von Stellungnahmen versammelt, die über die „Waldheim-Affäre“ hinaus das Weiterbestehen eines problematischen Umgangs Österreichs mit seiner nationalsozialistischen Vergangenheit kritisch beleuchten. Dieser Artikel konfrontiert in diskursanalytischer Perspektive die verharmlosende Verteidigungsstrategie des damaligen Bundespräsidenten und seine Aussage von der Pflichterfüllung mit den historisch perspektivierten Argumenten der in der Anthologie versammelten Schriftsteller, Künstler und Historiker, die ebenfalls die durch Waldheims Verleugnungen im In- und Ausland ausgelösten Reaktionen satirisch kommentieren. Besondere Beachtung findet dabei die in diesem Zusammenhang bemerkenswerte Reaktivierung von Kraus-Zitaten zu Polizeipräsident Schober und Hitler.
Un paradigme carinthien ? Le surgissement de la mémoire chez Werner Kofler, Josef Winkler et Maja Haderlap
Authors: Banoun Bernard 
Published: July 2024

A Carinthian Paradigma? Forms of representation of memory in texts by Werner Kofler, Josef Winkler and Maja Haderlap.
In this paper, we examinate the place of recent history in the works written by these three authors born in Carinthia. Our method refers to the researches by Aleida and Jan Assmann regarding memory literature, communicative memory and the intersection of historiography and literary writing. The works by the three authors are then interpreted from these points of view (rather short remarks about Winkler and Kofler, more precise enquiry about Maja Haderlap's novel Angel of Oblivion). The cultural memory work performed by the authors appears to be complementary to strict historiography and the paper shows that the regional aspects in their texts has to be understood in a wider context, the context of national and – first and foremost – of European history.
A Clinical Case of Familial Desmin Cardiomyopathy with a Restrictive Phenotype
Authors: Саркисян Л.Л. , Намитоков А.М. 
Published: July 2024

Десминовая кардиомиопатия (КМП) – это один из самых редких видов генетически обусловленных кардиомиопатий, который вызван мутацией в гене десмина (DES) и чаще всего дебютирует в возрасте 20–40 лет. Первыми клиническими проявлениями могут быть нарушения ритма и проводимости, синкопальные состояния, проявления сердечной недостаточности, поражение скелетной мускулатуры. Диагностика осуществляется с использованием эхокардиографического (ЭхоКГ), магнитно-резонансного (МРТ) методов исследования, зондирования полостей сердца, эндомиокардиальной биопсии и генетического скрининга. Редкая встречаемость, неспецифичность клинических проявлений, трудности диагностики являются причиной недостаточного количества клинических данных, отсутствия на данный момент эффективных методов лечения. На сегодняшний день лечение десминовой КМП направлено на купирование симптомов сердечной недостаточности, а также жизнеугрожающих аритмий. В статье приводится описание клинического случая семейной формы десминовой кардиомиопатии, ассоциированной с вариантом нуклеотидной последовательности (ВНП) в гене десмина (DES) с доминирующим кардиальным фенотипом рестриктивной кардиомиопатии.
Desmin cardiomyopathy(CMP) is one of the rarest types of genetically determined cardiomyopathies it is caused by a mutation in the desmin gene (DES) and most often debuts at the age of 20–40 years. The first clinical manifestations may be rhythm and conduction disorders, syncopal conditions, manifestations of heart failure and damage to skeletal muscles. Diagnosis is carried out using echocardiographic (ECHO), cardiac magnetic resonance (CMR), probing of the heart cavities, endomyocardial biopsy and genetic screening. A rare occurrence non-specificity of clinical manifestations and diagnostic difficulties the reason of the insufficient amount of clinical data and the lack of effective treatment methods at the moment. Today treatment of desmin cardiomyopathy is aimed at reliving symptoms of heart failure as well as life-threatening arrhythmias. The article describes a clinical case of a familial form of desmin cardiomyopathy associated with a variant of the nucleotide sequence (GNP) in the desmin gene with a dominant cardiac phenotype of restrictive cardiomyopathy.
FEATURES OF REMOTE MONITORING OF GEOCHEMICAL AND GEOPHYSICAL PROCESSES IN THE COASTAL ZONE
Authors: Мкртчян Ф.А. 
Published: July 2024

Охарактеризованы основные направления исследований в области изучения биологических, геохимических и геофизических процессов в прибрежной зоне (на примере Южно-Китайского моря в южном секторе Вьетнамского шельфа). Отмечены первостепенные проблемы, решение которых необходимо выполнить для достижения научных, экономических и социальных целей. Приведены фрагменты возможных подходов к решению поставленных задач и указаны нерешенные проблемы.
The main directions of research in the field of studying biological, geochemical and geophysical processes in the coastal zone are characterized (by the example of the South China Sea in the southern sector of the Vietnamese shelf). The primary problems are noted, the solution of which must be fulfilled in order to achieve scientific, economic and social goals. Fragments of possible approaches to solving the set tasks are given and unsolved problems are indicated.
Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients
Authors: Sun Pei-Qi , Dong Wen-Min , Yuan Yi-Fu , Cao Qin , Chen Xiao-Yan , Guo Li-Li , Jiang Yuan-Ye 
Published: July 2024

BACKGROUND
The annual incidence of metabolic-associated fatty liver disease (MAFLD) in China has been increasing and is often overlooked owing to its insidious characteristics. Approximately 50% of the patients have a normal weight or are not obese. They are said to have lean-type MAFLD, and few studies of such patients are available. Because MAFLD is associated with abnormal lipid metabolism, lipid-targeted metabolomics was used in this study to provide experimental evidence for early diagnosis and pathogenesis.
AIM
To investigate the serum fatty-acid metabolic characteristics in lean-type MAFLD patients using targeted serum metabolomic technology.
METHODS
Between January and June 2022, serum samples were collected from MAFLD patients and healthy individuals who were treated at Shanghai Putuo District Central Hospital for serum metabolomics analysis. Principal component analysis and orthogonal partial least squares-discriminant analysis models were developed, and univariate analysis was used to screen for biomarkers of lean-type MAFLD and analyze metabolic pathways. UPLC-Q-Orbitrap/MS content determination was used to determine serum palmitic acid (PA), oleic acid (OA), linoleic acid (LA), and arachidonic acid (AA) levels in lean-type MAFLD patients.
RESULTS
Urea nitrogen and uric acid levels were higher in lean-type MAFLD patients than in healthy individuals (P < 0.05). Alanine transaminase and cholinesterase levels were higher in lean-type MAFLD patients than in healthy individuals (P < 0.01). The expression of high-density lipoprotein and apolipoprotein A-1 were lower in lean-type MAFLD patients than in healthy individuals (P < 0.05) and the expression of triglycerides and fasting blood glucose were increased (P < 0.01). A total of 65 biomarkers that affected the synthesis and metabolism of fatty acids were found with P < 0.05 and variable importance in projection > 1”. The levels of PA, OA, LA, and AA were significantly increased compared with healthy individuals.
CONCLUSION
The metabolic profiles of lean-type MAFLD patients and healthy participants differed significantly, yielding 65 identified biomarkers. PA, OA, LA, and AA exhibited the most significant changes, offering valuable clinical guidance for prevention and treatment of lean-type MAFLD.