bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approach to the Patient Considering Long-term Antithyroid Drug Therapy for Graves’ Disease
Authors: Azizi Fereidoun , Mehran Ladan , Abdi Hengameh , Amouzegar Atieh 
Published: July 2024

Abstract
Antithyroid drugs (ATD) are the treatment of choice for the majority of patients with Graves’ hyperthyroidism worldwide. However, relapse of hyperthyroidism after withdrawal of arbitrarily chosen conventional 12 to 18 months of therapy is very common. In the last 2 decades, many studies have shown that treatment with long-term ATD (LT-ATD) is effective and safe in the maintenance of euthyroidism. In addition, it has been reported that serum TSH receptor antibody may not decrease permanently before 5 to 6 years of ATD treatment, and clinical trials have shown that ≥5 years of ATD treatment is accompanied by remission in the majority of patients with Graves’ hyperthyroidism. The objective of this article is to discuss the optimal time to withdraw of conventional ATD therapy, to illustrate the decision-making of the management of recurrent hyperthyroidism, to review the proper management of LT-ATD, and to generate suggestions for lifelong ATD treatment by discussing 4 scenarios of decision-making in patients with Graves’ disease.
Association Between Periodontitis and Cardiovascular Disease: Clinical Implications for Treatment and Prevention
Authors: Krasnoborska Julia , Szmyt Katarzyna , Samojedny Sylwia , Szymańska Katarzyna , Walczak Kamil , Wilk-Trytko Klaudia , Superson Maciej , Zarębska Juia 
Published: July 2024

Introduction and purpose: Chronic inflammation in the oral cavity poses significant risks to both the heart and the circulatory system. A growing number of studies indicate a correlation between periodontal health and the likelihood of developing cardiovascular conditions, including myocardial infarction, coronary artery disease, hypertension, and stroke. This review aims to summarize recent reports, define current state of knowledge, and propose optimal treatment and prevention strategies.
State of knowledge: Risk factors such as obesity, smoking, and genetic predisposition contribute to the development of both PD and cardiovascular diseases (CVDs). Inflammation serves as a common factor linking the two conditions, with periodontal pathogens directly affecting cardiovascular health. Epigenetic mechanisms, particularly in response to environmental stimuli, further exacerbate the relationship between PD and CVDs. Additionally, the oral microbiome plays a crucial role, with periodontal pathogens infiltrating systemic circulation and triggering immune-inflammatory responses that promote cardiovascular damage.
Conclusions: People with periodontitis have a higher risk of CVDs, especially when other risk factors such as smoking and obesity are present. Periodontal treatment has been demonstrated to enhance cardiovascular health parameters. Implementing preventive strategy, addressing both periodontitis and cardiovascular risk factors, could potentially decrease morbidity and mortality associated with cardiovascular disease.
A review of recent studies of both heat pipe and evaporative cooling in passive heat recovery
Authors: Mohsin Alsayah Ahmed , Faraj Johain J. , Eidan Adel A. 
Published: July 2024

Abstract
The present article aims to cover the most recent advancements in heat recovery technology in heating, ventilation, and air conditioning and identify areas that have not been thoroughly investigated. Extensive information is available on heat recovery technologies and exchangers in central systems. Furthermore, the research examines both direct and indirect evaporative cooling approaches. The literature discusses how the heat recovery process is influenced by climatic conditions, air flow rate, and the type of heat exchanger employed. The latest studies contributing to enhancing the performance of heat exchangers were also considered. The results of the study indicate that recent years have witnessed great interest from researchers in the field of lost energy recovery; the experimental, theoretical, and numerical studies have focused on studies of the influencing factors that contribute to improving the performance of the energy recovery process. The current project involves doing an analytical and comparative analysis of the newest research about enhancing the efficiency of thermosyphon heat exchangers and various forms of evaporative cooling.
Insights in caveolae protein structure arrangements and their local lipid environment
Authors: Ocket Esther , Matthaeus Claudia 
Published: July 2024

Abstract
Caveolae are 50–80 nm sized plasma membrane invaginations found in adipocytes, endothelial cells or fibroblasts. They are involved in endocytosis, lipid uptake and the regulation of the cellular lipid metabolism as well as sensing and adapting to changes in plasma membrane tension. Caveolae are characterized by their unique lipid composition and their specific protein coat consisting of caveolin and cavin proteins. Recently, detailed structural information was obtained for the major caveolae protein caveolin1 showing the formation of a disc-like 11-mer protein complex. Furthermore, the importance of the cavin disordered regions in the generation of cavin trimers and caveolae at the plasma membrane were revealed. Thus, finally, structural insights about the assembly of the caveolar coat can be elucidated. Here, we review recent developments in caveolae structural biology with regard to caveolae coat formation and caveolae curvature generation. Secondly, we discuss the importance of specific lipid species necessary for caveolae curvature and formation. In the last years, it was shown that specifically sphingolipids, cholesterol and fatty acids can accumulate in caveolae invaginations and may drive caveolae endocytosis. Throughout, we summarize recent studies in the field and highlight future research directions.
Transmigrant identities and attitudes: the case of a Pangasinan-American family
Authors: Bernardo-Hinesley Sheryl , Arias Álvarez Alba 
Published: July 2024

Abstract
Identity plays a crucial role in determining whether diasporic minority communities either integrate into the host country or resist acculturation and assimilation. Since identity is performed and negotiated through discourse, the study of connections between identity and language practices of migrant groups is crucial in understanding how language is used to express their multilayered identities. Using sociolinguistic interviews as the primary data source, this research analyzes how three generations of a Pangasinan-American family negotiate their complex identities and express their attitudes towards English, Filipino, and Pangasinan. Findings show that their Pangasinan-American identity is performed through translingual practices, which enable the portrayal of their membership to their home community and their integration into the host society. Each participant situates their Pangasinan identity in relation to their other identities – Filipino and American – which emerge in the diasporic context. This study contributes to the research on the role of language in the development of community membership and allegiances of bi-/multilingual transmigrants.
Entropy generation analysis of MHD convection flow of hybrid nanofluid in a wavy enclosure with heat generation and thermal radiation
Authors: Hussain Syed M. , Parveen Rujda , Katbar Nek Muhammad , Rehman Sadique , Abd-Elmonem Assmaa , Abdalla Nesreen Sirelkhtam Elmki , Ahmad Hijaz , Qureshi Muhammad Amer , Jamshed Wasim , Amjad Ayesha , Ibrahim Rabha W. 
Published: July 2024

Abstract
This work examines the behaviour of flow and heat transmission in the presence of hybrid nanofluid in thermal radiation, heat generation, and magnetohydrodynamics. The hybrid state in this model is represented by two different fluids, TiO2 (titanium dioxide) and Ag (silver). The enclosure is wavy and slanted, with curving walls on the left and right. The finite difference approximation method was utilized to resolve the fundamental equations after they were non-dimensionalized, which are further reduced to a fourth-order bi-harmonic equation and are numerically solved based on the biconjugate gradient-stabilized approach method. The simulations are performed with various Rayleigh numbers, Hartmann numbers, an inclination angle of the enclosure, radiation parameters, heat generation parameters, inclination angle of the magnetic field, and volume fraction of hybrid nanoparticles. The streamlines, isotherms, and average Nusselt number contours are used to depict the thermo-fluid patterns. The findings show that the average Nusselt number relies on ϕ and increases as ϕ rises. The investigation’s findings demonstrated that the transfer of heat on the heated bottom wall significantly increases with the Rayleigh number (Ra = 105 and 106). At a cavity inclination of 45°, interesting multi-vortex structures are observed. The results of this study may enhance the effectiveness of solar collectors, heat exchangers, and other similar systems that depend on convective heat transfer in nature.
Decolonial Perspectives from Latin America
Authors: Zambonini Juan Pedro , Tosto Virginia 
Published: July 2024

This editorial discusses specific coordinates for thinking about decolonial perspectives from Latin America. It explores the notions of academic dependence, epistemic colonialism and situated thought as axes within the decolonial perspective. It also extends an invitation to Latin American music therapists to participate in a special edition to be published in 2025. Lastly, a brief description of the articles included in this journal edition is provided.
Resumen
Este editorial contempla certas coordenadas para pensar sobre as perspectivas decoloniais da América Latina. Ele explora as noções de dependência acadêmica, colonialismo epistêmico e pensamento situado como eixos dentro da perspectiva decolonial. Também faz um convite aos musicoterapeutas latino-americanos para participarem de uma edição especial a ser publicada em 2025. Por fim, é apresentada uma breve descrição dos artigos incluídos nesta edição da revista.
Resumen
Esta editorial contempla ciertas coordenadas para pensar las perspectivas decoloniales desde Latino America. Explora las nociones de dependencia academica, colonialismo epistemico y pensamiento situado como ejes dentro de la perspectiva decolonial. Asimismo, se extiende una invitacion a musicoterapeutas latinoamericanos para ser parte de una edición especial que será publicada en 2025. Por ultimo, se brinda una breve descripción de los artículos incluidos en esta edición de la revista.
CLINICAL CASE OF SUCCESSFUL TREATMENT OF A PATIENT WITH AORTIC ROOT ANEURYSM AND PULMONARY ARTERY STENOSIS AFTER RADICAL CORRECTION OF PULMONARY ARTERY ATRESIA WITH VENTRICULAR SEPTAL DEFECT
Authors: Charchyan Eduard R. , Breshenkov Denis G. , Lezhnev Alexander A. , Baidin Sergey P. , Belov Yuri V. 
Published: July 2024

HighlightsThe article presents a clinical case of successful treatment of a patient with aortic root aneurysm and pulmonary artery stenosis after radical three-stage repair of pulmonary atresia with ventricular septal defect. Abstract Aortic root aneurysm with aortic regurgitation is a rare cause of re-operation in patients who have had primary repair of pulmonary atresia with ventricular septal defect or tetralogy of Fallot. Recently, due to an increase in cases of primary radical treatment of congenital cardiac surgery and life expectancy of these patients, the number of cases of re-operation due to aortic root dilatation has also increased. One of the main reasons for long-term aortic regurgitation and of aortic root enlargement is the presence of a subaortic ventricular septal defect below the aortic valve, which deforms the aortic annulus geometry and changes intra-aortic hemodynamics. All of these factors make the aortic root surgical reconstruction just a question of time. This is a real challenge for both adult and pediatric heart surgeons, requiring a team approach. This article presents a clinical case of successful treatment of a patient with aortic root aneurysm, aortic regurgitation with concomitant pulmonary conduit restenosis and residual ventricular septal defect who underwent a three-stage repair of pulmonary atresia and ventricular septal defect.
ASSESSMENT OF THE FUNCTIONAL SIGNIFICANCE OF STENOSIS IN MULTIVESSEL CORONARY ARTERY DISEASE BASED ON INTEGRAL INSTANT FLOW RESERVE
Authors: Gromovoy Roman M. , Pekarskiy Stanislav E. , Baev Andrey E. , Gergert Egor S. , Tarasov Mikhail G. , Sultanov Syrgak M. , Bogdanov Yuri I. , Suslov Ivan V. , Gorokhovsky Alexey A. , Falkovskaya Alla Y. , Manukyan Musheg A. 
Published: July 2024

HighlightsThe assessment of the anatomical significance of multivessel atherosclerosis of the coronary arteries – SYNTAX score takes into account the level and multiplicity of lesions by assigning higher scores for proximal stenoses and subsequent summation. Functional assessment of coronary blood flow – instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) uses one threshold value for all stenoses, and does not take into account their multiplicity. Aim. To develop a new indicator for the integral assessment of the functional significance of multivessel atherosclerosis of the coronary arteries, taking into account the level and multiplicity of lesions.Methods. The model for the integral assessment of the functional significance of a multivessel lesion was the sum of the transstenotic gradients (in our variant 1-iFR) of all stenoses >50%, weighted by the volume of the dependent LV myocardium, which was evaluated on the Duke jeopardy score: Σ(1-iFRi)*Nd, where Nd is the number of Duke dependent segmental arteries supplying blood to 1/6 of the myocardium. To bring the obtained values to the range 0–1 and the threshold level 0.89, the 1/(1+X) transformation was used, i.e. in the case of single non-proximal stenoses, the integral assessment index is equal to the value of the standard iFR. To test the ability of the indicator to take into account the level and multiplicity of lesions, we evaluated its relationship with SYNTAX in patients with multivessel coronary artery disease (>2 segments with stenoses >50%), including in comparison with standard iFR (minimum value). The VERRATA PLUS conductor and the Core module of the Phillips Azurion angiographic system were used for iFR measurements.Results. The study included 42 patients, 29 men and 13 women, aged 65.3 ± 8.9 years, with multivessel coronary artery disease, SYNTAX score = 11.5 ± 2.7. The calculated values of integral iFR were expected to be less than the minimum standard iFR: 0.71 ± 0.11 versus 0.81 ± 0.14, respectively, p < 0,001. Integral iFR demonstrated significant inverse dependence on SYNTAX, p = 0,34, p < 0,05, whereas the standard iFR did not depend on SYNTAX. The number of patients with non-significant standard iFR, but significant integral iFR was 23.5% compared to patients with significant standard iFR. In accordance with the nature of the calculations, there were no cases of significant standard iFR and insignificant integral iFR.Conclusion. The obtained data demonstrated the possibility of taking into account the level and multiplicity of stenoses when assessing the functional significance of coronary artery lesions using the iFR method.
PREDICTION OF CARDIOVASCULAR RISK IN ABDOMINAL SURGERY: RESULTS OF AN OBSERVATIONAL MULTICENTER STUDY
Authors: Zabolotskikh Igor B. , Veyler Roman V. , Trembach Nikita V. , Magomedov Marat A. , Popov Alexander S. , Malyshev Yuri P. , Dmitriev Alexey A. , Grigoryev Evgeny V. , Fisher Vasily V. , Khoronenko Victoria E. , Kokhno Vladimir N. , Spasova Arina P. , Davydova Veronika R. , Gritsan Alexey I. , Lebedinskii Konstantin M. , Dunts Pavel V. , Bayalieva Ainagul Z. , Ovezov Alexey M. , Martynov Dmitry V. , Kirov Mikhail Yu. , Ershov Vadim I. , Murashko Svetlana S. , Kuzovlev Artem N. , Fedunets Dmitriy E. 
Published: July 2024

HighlightsThe developed prediction model is a simple and accurate method for assessing the postoperative risk of cardiovascular complications in a large population of patients undergoing non-cardiac surgery. Its widespread use will optimize perioperative management tactics and improve surgical results. Aim. To develop a model for predicting cardiovascular risk in patients undergoing abdominal surgery and compare its accuracy with foreign analogs validated on a domestic cohort of patients.Methods. The multicenter prospective study included 8 241 patients over 18 years of age undergoing elective abdominal surgery. The following postoperative complications were assessed: acute myocardial infarction, stroke, cardiac arrest, cardiogenic pulmonary edema, pulmonary embolism, and 30-day mortality. First of all, we compared baseline characteristics of patients with and without complications, and factors, associated with surgery and anesthesia. Next, we performed a logistic regression analysis to assess the contribution of factors to the development of postoperative cardiovascular complications. Following that, we developed a model for predicting postoperative cardiac risk based on the data of multivariate logistic regression analysis. Finally, we compared the obtained model with other prediction models found in the literature.Results. Out of 8241 patients, 53 patients (0.64%) presented with cardiovascular complications (62 cases): cardiac arrest in 39 patients (0.47%), cardiogenic pulmonary edema in 4 patients (0.049%), stroke in 3 patients (0.036%), pulmonary embolism in 9 patients (0.11%), and acute myocardial infarction in 7 patients (0.084%). 36 patients (0.43%) had lethal outcome. Retrospectively, the obtained model assigned 2251 patients to the high-risk group for developing cardiovascular complications, the incidence of cardiovascular complications in the group was 2.1%. The low-risk group consisted of 5 990 patients; the incidence of cardiovascular complications in the group was 0.13%.Conclusion. Eight independent variables associated with postoperative cardiovascular complications were identified: high and moderate surgical trauma, smoking, statin use, Stange test less than 40 seconds, American Society of Anesthesiologists functional class 3, intraoperative need for vasopressors and transfusions. The cardiovascular risk prediction model has good predictive power (AUROC = 0.880).
ERYTHROCYTE MEMBRANE ADRENOREACTIVITY IN CHILDREN WITH DRUG-RESISTANT VENTRICULAR EXTRASYSTOLE BEFORE AND AFTER RADIOFREQUENCY ABLATION
Authors: Rebrova Tatiana Yurievna , Perevoznikova Yulyana Evgenievna , Muslimova Elvire Faritovna , Svintsova Liliya Ivanovna , Plotnikova Irina Vladimirovna , Afanasiev Sergei Aleksandrovich 
Published: July 2024

HighlightsFor children aged 11–15 years with the duration of ventricular arrhythmias from 1 to 2 years, the increased value of β-adrenergic reactivity of erythrocyte membranes (β-ARM) is characteristic in comparison with the group of healthy children of the same age, which indicates desensitization of β-adrenoreceptors. In the early postoperative period after the elimination of ventricular ectopic focus as a result of radiofrequency ablation β-ARM continues to increase. The possibility of using the β-ARM index to assess the state of the sympathetic part of the autonomic nervous system in the category of patients with methodological limitations of heart rate variability analysis was studied. AbstractAim. To evaluate the activity of the autonomic nervous system by changes in β-adrenoreactivity of erythrocyte membranes (β-ARM) in children with drug-resistant ventricular arrhythmia (VA) before and three days after radiofrequency ablation (RFA).Methods. The study included 11 children aged 13 [11;15] years old with drug-resistant ventricular arrhythmia, who had documented ventricular extrasystoles (VE) with ectopic activity exceeding 10%, including those accompanied by episodes of ventricular tachycardia (VT) (ZHA group). The control group consisted of 11 children 14 [12;16] years old who did not have the pathology of the cardiovascular system. Determination of β-ARM of erythrocytes in blood samples was performed using the BETA-ARM AGAT reagent kit (AGAT LLC, Russia).Results. At the time of hospitalization in the VA group the β-ARM indicator was significantly (p = 0.026) higher than the values in the control group. 3 days after RFA in children with VA the median β-ARM increased by 62.3% compared to the initial values in the group (p = 0.027).Conclusion. Children with VA and an arrhythmological history of more than 1 year are characterized by a predominance of activity of the sympathetic division of the autonomic regulation of the cardiovascular system. The systemic nature of the predominance of sympathetic influence is manifested in an increase in the β-ARM index relative to control values. In the early postoperative period, after the elimination of the ventricular ectopic focus as a result of RFA, an increase in β-ARM occurs, which indicates desensitization of adrenergic receptors, which also contributes to a decrease in the influence of the sympathetic system. The study demonstrated the possibility of using the β-ARM indicator to assess the response of the sympathetic system in a category of patients with methodological limitations in HRV analysis.
SIXTY-FIVE YEARS OF SURGICAL TREATMENT OF LEFT VENTRICULAR ANEURYSM USING CARDIOPULMONARY BYPASS: D. COOLEY, C. LILLEHEI, BORIS V. PETROVSKY
Authors: Protopopov Andrey V. , Sirota Dmitry A. , Zhulkov Maxim O. , Agaeva Khava A. 
Published: July 2024

HighlightsThe literature review is dedicated to the 65th anniversary of the first left ventricular aneurysm resection performed with cardiopulmonary bypass.The main stages of the development of surgical treatment of aneurysms are highlighted.The life and professional path of the leading specialists of the twentieth century who made an invaluable contribution to the treatment of patients with heart aneurysms are described. AbstractThe article is devoted to a review of development of left ventricular aneurysm surgery, as well as a brief autobiographical review, from the first description by John Hunter in the 18th century to the stages of emergence and development of modern methods of left ventricular reconstruction both on the working heart and with cardiopulmonary bypass.The review analyzes the stages of development of surgical treatment of left ventricular aneurysms: starting with the first description of the disease made by J. Hunter in the 18th century, before the advent of modern methods of aneurysm surgery both off- and on-pump.