bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response
Authors: Leoni Giovanna , Gripentrog Jeannie , Lord Connie , Riesselman Marcia , Sumagin Ronen , Parkos Charles A , Nusrat Asma , Jesaitis Algirdas J 
Published: November 2014

Abstract
Bacterial/mitochondrial fMLF analogs bind FPR1, driving accumulation/activation of PMN at sites of infection/injury, while promoting wound healing in epithelia. We quantified levels of UFPR1 and TFPR1 in isolated PMN by use of phosphosensitive NFPRb and phosphorylation-independent NFPRa antibodies. UFPR1 and total TFPR were assessed inflamed mucosa, observed in human IBD. In isolated PMN after fMLF stimulation, UFPR1 declined 70% (fMLFEC50 = 11 ± 1 nM; t1/2 = 15 s) and was stable for up to 4 h, whereas TFPR1 changed only slightly. Antagonists (tBoc-FLFLF, CsH) and metabolic inhibitor NaF prevented the fMLF-dependent UFPR1 decrease. Annexin A1 fragment Ac2-26 also induced decreases in UFPR1 (Ac2-26EC50 ∼ 3 µM). Proinflammatory agents (TNF-α, LPS), phosphatase inhibitor (okadaic acid), and G-protein activator (MST) modestly increased fMLFEC50, 2- to 4-fold, whereas PTX, Ca2+ chelators (EGTA/BAPTA), H2O2, GM-CSF, ENA-78, IL-1RA, and LXA4 had no effect. Aggregation-inducing PAF, however, strongly inhibited fMLF-stimulated UFPR1 decreases. fMLF-driven PMN also demonstrated decreased UFPR1 after traversing monolayers of cultured intestinal epithelial cells, as did PMN in intestinal mucosal samples, demonstrating active inflammation from UC patients. Total TFPR remained high in PMN within inflamed crypts, migrating through crypt epithelium, and in the lamina propria-adjoining crypts, but UFPR1 was only observed at some peripheral sites on crypt aggregates. Loss of UFPR1 in PMN results from C-terminal S/T phosphorylation. Our results suggest G protein–insensitive, fMLF-dependent FPR1 phosphorylation in isolated suspension PMN, which may manifest in fMLF-driven transmigration and potentially, in actively inflamed tissues, except at minor discrete surface locations of PMN-containing crypt aggregates.
Antioxidant defense and stress protein induction following heat stress in the Mediterranean snailXeropicta derbentina[Pulmonata, Hygromiidae]
Authors: Troschinski Sandra , Dieterich Andreas , Krais Stefanie , Triebskorn Rita , Koehler Heinz-R. 
Published: November 2014

AbstractThe Mediterranean snail Xeropicta derbentina, being highly abundant in Southern France, has the need for efficient physiological adaptations to desiccation and over-heating posed by dry and hot environmental conditions. In consequence of heat, oxidative stress manifests in these organisms, which, in turn, leads to the formation of reactive oxygen species (ROS). In this study, we focused on adaptations on the biochemical level by investigation of antioxidant defenses and heat shock protein 70 (Hsp70) induction, both essential mechanisms of the heat stress response. We exposed snails to elevated temperature (25, 38, 40, 43, and 45°C) in the laboratory and measured the activity of the antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx), determined the Hsp70 level, and quantified lipid peroxidation. In general, we found a high constitutive level of CAT activity in all treatments, which may be interpreted as a permanent protection against ROS, i.e. hydrogen peroxide. CAT and GPx showed temperature-dependent activities: CAT activity was significantly increased in response to high temperatures (43 and 45°C), whereas GPx exhibited a significantly increased activity at 40°C, likely in response to high levels of lipid peroxides which already occurred in the 38°C treatment. Hsp70 showed a maximum induction at 40°C, followed by a decrease at higher temperatures. Our results reveal that X. derbentina possesses a set of efficient mechanisms to cope with damaging effects by heat. Furthermore, we could demonstrate that, beside the well documented Hsp70 stress response, the antioxidant defense plays a crucial role in these snails competence to survive extreme temperatures.
CPD article: Cervical cancer care
Authors: Peate Ian , Jones Noleen 
Published: November 2014

This article provides the healthcare assistant (HCA) and assistant practitioner (AP) with an overview of cervical cancer. Cervical cancer is a preventable cancer. Cervical cancer is the twelfth most common cancer in women in the UK and the third most common gynaecological cancer after uterus (womb) and ovary (Cancer Research UK). The anatomy and physiology of the female genitourinary tract are outlined. The incidence and prevalence of the condition are presented. There are a number of risk factors related to this condition and these are discussed, along with the signs and symptoms of cervical cancer and the diagnosis through a smear test. The various treatment options are reviewed, emphasising the need to ensure that the woman's unique needs are being met and respected. The role and function of the HCA and AP are key to ensuring care is safe, kind and compassionate, with the patient at the centre of all that is done.
People living with dementia: components of communication
Authors: Nazarko Linda 
Published: November 2014

Communication skills are vitally important for the healthcare assistant (HCA). The HCA works in a team and cares for vulnerable people who may, because of illness or distress, have difficulty in communicating. Communicating effectively enables the HCA to work well in a team and to ensure that the voice of the patient is heard. Communication is a skill that we all take for granted, yet misunderstandings are common. This article aims to analyse different components of communication and to enable the reader to understand the components of communication and how to improve communication skills.
Looking to the future of HCA education in the UK
Authors: Hayes Catherine 
Published: November 2014

This article is written for both HCAs and their educators and outlines some of the major approaches to developing education and training for the HCA workforce. Referring to major policy recommendations and how this might be translated into working curricula for HCAs, there is discussion of the presuppositions around vocational and academic training for the HCA workforce and how parallel issues in industry have been addressed in practice. E-learning is debated as a mechanism of integrating emergent technology into HCA curricula via the facilitation of learning in both simulation and delivery of academic content. The impact of this on HCA learning in practice is considered. Finally, a set of key objectives for HCAs is identified and the article concludes with an outline of potential innovation for HCA education when regulation of this sector of the healthcare workforce is formalised in the near future
Moments of hospitality: Rethinking hospital meals through a non-representational approach
Authors: Justesen Lise , Gyimóthy Szilvia , Mikkelsen Bent E. 
Published: November 2014

Abstract
Hospital meals have increasingly become part of the political and scientific agenda of the welfare discussions in Denmark and other European countries. This article employs non-representational theory to analyse hospitalityscapes in order to explore opportunities for adding value to the hospital meal experience. By drawing on research carried out in two Danish hospital wards, this article explores how hospitalityscapes are socio-materially constructed. The research strategy was based on performative participant observations, visual ethnography and semi-structured interviews. The empirical data reveal how the daily atmosphere could be changed by social activities such as a dancing nurse, or through artefacts such as meatballs or napkins in disruptive micro-events, creating a possibility for different hospitalityscapes manifested in cultural, humorous or social performances. The article suggests that a focus on disruptive micro-events might create opportunities for hospitalityscapes and add value to future hospital meal experiences.
Work for food and accommodation: Negotiating socio-economic relationships in non-commercial work-exchange encounters
Authors: Kosnik Elisabeth 
Published: November 2014

Abstract
The concept of ‘work for food and accommodation’ is part of a significant social trend in contemporary societies, of the slow food, sustainability and back-to-the-land movement. It is an alternative form of travelling and hospitality as much as it is part of an alternative economy that deliberately avoids encounters governed by the logics of the market, where people seek alternative ways of engaging with, and relating to, others. Taking the international World Wide Opportunities on Organic Farms (WWOOF) movement as my empirical context, I investigate the nature of hospitality in the work-exchange relationship by analysing how participants negotiate their social and economic relationships through food and reciprocity. Based on ethnographic research, this article discusses power and boundaries, social control, inclusion and exclusion, and exchange and reciprocity between hosts and helpers, demonstrating how the host–guest dichotomy dissolves when the boundaries between production and consumption become blurred. I argue that food and beverage, hospitality and mutual help play a significant role in establishing, negotiating and nurturing these exchange relationships between barter and gift exchange. There is a dearth of research on work-exchange that this article addresses. Drawing on insights from ethnographic and other social science research alongside theoretical discussions of hospitality ‘as a way of relating’, the article aims to contribute new ways of understanding and theorizing the work-exchange encounter.
Reviews
Authors: Berno Tracy , Murray Elizabeth , Pavoni Andrea , O’Halloran Robert M. 
Published: November 2014

Abstract
Food and Drink: The Cultural Context, Donald Sloan (ed.) (2013) Woodeaten, Oxford: Goodfellow Publishers Ltd, 245 pp., ISBN: 9781908999047, p/bk, £29.99
Semiotics of Drinks and Drinking, Paul Manning (2012) London: Continuum, 245 pp., ISBN: 9781441137746, p/bk, £24.99
Educated Tastes: Food, Drink and Connoisseur Culture, Jeremy Strong (ed.) (2011) Lincoln: University of Nebraska Press, xxii+292 pp., ISBN: 9780803219359, p/bk, £23.99
Eating Asian America: A Food Studies Reader, Robert Ji-Song Ku, Martin F. Manalansan IV and Anita Mannur (eds) (2013) New York and London: New York University Press, 444 pp., ISBN1: 9781479810239 (cl), ISBN2: 9781479869251 (pb), p/bk, $20.35, Kindle, $11.99
Winds from the North: Tewa Origins and Historical Anthropology
Authors: Dombrosky Jonathan 
Published: November 2014

Review of Winds from the North: Tewa Origins and Historical Anthropology. Scott G. Ortman. 2012. The University of Utah Press, Salt Lake City. Pp. 520, 51 illustrations, 25 maps, 54 tables. $70.00 (hardcover). ISBN 978-1-60781-172-5.
Deconstruction and Reconstruction of the “Comply or Explain” Principle in EU Capital Markets
Authors: Sergakis Konstantinos 
Published: November 2014

AbstractThe “comply or explain” principle has already acquired significant importance in corporate law and regulations and is considered to be the preferred regulatory tool in the EU for increasing transparency and disclosure of market participants’ strategies and activities. The flexibility of the principle is perceived as the most suitable way to create indirect coordination of practices amongst market actors, as well as better mutual understanding of their different priorities. Having initially shown its considerable appeal in the area of corporate governance statements issued by corporate entities, it has now expanded its influence into other areas serving similar transparency imperatives, such as the exercise of stewardship responsibilities by institutional investors and proxy advisors. In this paper, we will focus on the merits and shortfalls of the “comply or explain” principle in all the above-mentioned areas, both at national and at EU levels, and will critically challenge its effectiveness in the current regulatory framework. Moreover, we will seek to justify its continued use by demonstrating its future potential role as a veritable dialogue spectrum between different market participants. Lastly, we will emphasise the need for a soft monitoring process from national regulators which will enable both the “comply or explain” principle and its users to participate in a holistic effort for the adoption of sound investment strategies via the fruitful exchange of views and ideas and better communication with regard to their respective role in capital markets.
Refining Tungsten Purification by Electron Beam Melting Based on the Thermal Equilibrium Calculation and Tungsten Loss Control
Authors: Long Luping , Liu Wensheng , Ma Yunzhu , Liu Ye , Liu Shuhua 
Published: November 2014

AbstractElectron beam melting (EBM) technology has been considered as one of the key steps for preparing high purity tungsten, and reasonable setting of process parameters is the premise. In this paper, the optimum process parameters obtained from thermal equilibrium calculation and evaporation loss control of tungsten are presented. Effective power is closely related to melting temperature, and the required power for maintaining the superheating melt linearly increases with the increase of melt superheat temperature. The evaporation loss behavior of tungsten is significantly influenced by melting rate and melting temperature. Analysis of experiments show that the best results are realized at melting rate of 1.82 g/s, melting temperature of 4200 K, and the corresponding melting power of 130 kW, in which the main impurity elements in tungsten, such as As, Cd, Mg and Sn, present high removal ratio of 90%, 95%, 85.7% and 90%, respectively.
A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans
Authors: Romanos Teresa Rojo , Petersen Jakob Gramstrup , Riveiro Alba Redo , Pocock Roger 
Published: November 2014

Abstract
Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode C. elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the coexpression of a membrane-bound receptor-type guanylyl cyclase GCY-9 that is required for responses to CO2 upshifts and the soluble guanylyl cyclases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, although not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.
Late-Emerging Lethal Exacerbation of Cardiomyopathy in a Patient with Mitochondrial Myopathy After Total Hip Arthroplasty
Authors: Mimura Tomohiro , Imai Shinji , Kawasaki Taku , Furuya Yuki , Mori Kanji , Matsusue Yoshitaka 
Published: November 2014

Case:
Mitochondrial myopathy comprises heterogeneous neuromuscular disorders caused by mitochondrial dysfunction. Acute exacerbation of mitochondrial myopathy infrequently occurs sequentially after perioperative stress. We present an unusual case of a late-emerging and lethal exacerbation of mitochondrial myopathy after total hip arthroplasty. Despite special attention paid to perioperative control, the patient’s condition drastically deteriorated on postoperative day thirteen, and she died later as a result of cardiomyopathy.

Conclusion:
When performing surgery on a patient with mitochondrial myopathy, the merits of surgery must always surpass the possible grave risk of this condition.
Hodgkin Lymphoma Presenting as Severe Shoulder Pain Following Small Quantities of Alcohol Ingestion
Authors: Feldman Viktor , Nyska Meir , Barchilon Vidal 
Published: November 2014

Case:
Shoulder pain is a common symptom. We report a case of a twenty-two-year-old man who had shoulder pain that was induced by small quantities of alcohol ingestion, which is an unusual presenting sign of Hodgkin lymphoma. The history, physical examination of the shoulder, and imaging revealed no noteworthy findings. Chest computed tomography and subsequent biopsy led to the diagnosis of Hodgkin lymphoma.

Conclusion:
This report emphasizes the need to consider Hodgkin lymphoma as part of the differential diagnosis in a patient presenting with shoulder pain that is precipitated by alcohol ingestion.
Treatment of a Chronic Multidrug-Resistant Cutaneous Mycobacterium chelonae Infection of the Hand with Wide Debridement and Skin-Grafting
Authors: Wang Mark L. , Vosbikian Michael M. , Abboudi Jack , Beredjiklian Pedro K. 
Published: November 2014

Case:
We present a case of a healthy thirty-seven-year-old woman with a chronic cutaneous Mycobacterium chelonae infection of the hand recalcitrant to antibiotics and excisional biopsies. She was treated with wide excision of the lesion and staged full-thickness skin-grafting. At the sixth-month follow-up, she reported no activity limitations and demonstrated full painless digital motion without evidence of recurrent infection.

Conclusion:
The technique presented offers the advantage of early digital range of motion with temporary soft-tissue coverage prior to definitive coverage with a full-thickness skin graft while laboratory analysis is performed.
Effect of Ligation Method on Maxillary Arch Force/Moment Systems for a Simulated Lingual Incisor Malalignment
Authors: Seru Surbhi , Romanyk Dan L , Toogood Roger W , Carey Jason P , Major Paul W 
Published: November 2014

Introduction:
The objectives of this study were to determine whether there is a difference in the magnitude of forces and moments produced by elastic ligation when compared to passive ligation, and whether these forces and moments propagate differently along the arch for the two ligation types. A lingual incisor malalignment was used in this study.

Methods:

The Orthodontic Simulator (OSIM) was used to quantify the three-dimensional forces and moments applied on the teeth given a lingually displaced incisor. A repeated measures MANOVA was performed to statistically analyze the data.

Results:

The interaction factor illustrated convincing evidence that there is a difference in maximum force and moment values for all outcome variables between ligation types considering all tooth positions along the arch. The mean differences for FX and FY between ligation types were found to be clinically significant, with values for elastic ligation consistently higher than passive ligation.

Conclusion:

It was found that the maximum forces and moments produced by elastic ligation are greater than those produced by passive ligation and that the magnitude of this difference for the mesiodistal and buccolingual forces is clinically relevant. Additionally, it was determined that elastic ligation causes forces and moments to propagate further along the arch than passive ligation for all outcome variables.
States on bounded commutative residuated lattices
Authors: Kondo Michiro 
Published: November 2014

Abstract
We define states on bounded commutative residuated lattices and consider their property. We show that, for a bounded commutative residuated lattice X,
(1)If s is a state, then X/ker(s) is an MV-algebra.(2)If s is a state-morphism, then X/ker(s) is a linearly ordered locally finite MV-algebra.

Moreover we show that for a state s on X, the following statements are equivalent:
(i)s is a state-morphism on X.(ii)ker(s) is a maximal filter of X.(iii)s is extremal on X.
On a strengthened multidimensional Hilbert-type inequality
Authors: Krnić Mario 
Published: November 2014

Abstract
The main objective of this paper is a study of the general refinement and converse of the multidimensional Hilbert-type inequality in the so-called quotient form. Such extensions are deduced with the help of the sophisticated use of the well-known Hölder’s inequality. The obtained results are then applied to homogeneous kernels with the negative degree of homogeneity. Also, we establish the conditions under which the constant factors involved in the established inequalities are the best possible. Finally, we consider some particular settings with homogeneous kernels and weighted functions. In such a way we obtain both refinements and converses of some actual results, known from the literature.
A representation of skew effect algebras
Authors: Chajda Ivan 
Published: November 2014

Abstract
It was shown by the author and R. Halaš that every effect algebra can be organized into a conditionally residuated structure. Skew effect algebras were introduced as a non-associative modification of effect algebras. Hence, there is natural question if a similar characterization by a certain residuated structure is possible. For this we use the so-called skew residuated structure introduced recently by the author and J. Krňávek. It is shown that this is really a suitable tool for the representation.
Low-temperature synthesis of zeolite from perlite waste — Part II: characteristics of the products
Authors: Król Magdalena , Morawska Justyna , Mozgawa Włodzimierz , Pichór Waldemar 
Published: November 2014

Abstract
The paper investigates the properties of sodium zeolites synthesized using the hydrothermal method under autogenous pressure at low temperature with NaOH solutions of varying concentrations. During this modification, zeolites X, Na-P1 and hydroxysodalite were synthesized. The synthesis parameters, and thus, phase composition of resulting samples, significantly affected the specific surface area (SSA) and cation exchange capacity (CEC). SSA increased from 2.9 m2/g to a maximum of 501.2 m2/g, while CEC rose from 16 meq/100 g to a maximum of 500 meq/100 g. The best properties for use as a sorbent were obtained for perlite waste modified with 4.0 M NaOH at 70 °C or 80 °C.