bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing intervention to enhance outpatient chemotherapy symptom management: Patient‐reported outcomes of a randomized controlled trial
Authors: Traeger Lara , McDonnell Theresa M. , McCarty Caitlin E. , Greer Joseph A. , El‐Jawahri Areej , Temel Jennifer S. 
Published: July 2015

BACKGROUNDThe authors conducted a randomized controlled trial to evaluate a nurse practitioner (NP)‐delivered symptom management intervention for patients initiating chemotherapy for nonmetastatic cancer. The aim was to reduce patient‐reported symptom burden by facilitating patient‐NP collaboration and the early management of symptoms.METHODSAt the time of the first chemotherapy visit, adult participants with nonmetastatic breast, colorectal, or lung cancer (120 participants) completed self‐report measures and were then randomly assigned to standard care plus the intervention or standard care alone. Intervention participants received proactive telephone calls from their oncology team NP during the week after each of the first 2 chemotherapy administration visits. Measures were repeated at the second and third chemotherapy visits. Group differences were analyzed with regard to patient‐reported symptoms (Memorial Symptom Assessment Scale‐Short Form items), satisfaction with care (Family Caregiver Satisfaction‐patient scale), and the likelihood of depression or anxiety symptoms (Patient Health Questionnaire‐4).RESULTSAt the time of the first visit, 50.8% of participants reported ≥1 physical symptom, most commonly lack of energy (35.8%) and drowsiness (30.8%). The number of symptoms (gamma coefficient [γ] = 0.16; P<.001), symptom distress (γ = 0.45; P<.001), and satisfaction with care (γ = 0.24; P = .004) increased whereas the likelihood of anxiety symptoms decreased (γ = ‐0.19; P = .02) and the likelihood of depression symptoms did not change (γ = 0.01; P = .91). Outcomes did not differ by randomized group. Randomized group interacted with emetogenic potential in predicting symptom distress (γ = 0.43; P = .03) and satisfaction with care (γ = ‐0.45; P = .045).CONCLUSIONSThe intervention did not appear to reduce symptom burden compared with standard care. Early symptoms highlight the importance of continuing to examine strategies to improve symptom management during chemotherapy for nonmetastatic disease. Cancer 2015;121:3905–3913. © 2015 American Cancer Society.
Effect of species, pretreatments, and drying methods on the functional and pasting properties of high‐quality yam flour
Authors: Wahab Bashirat A. , Adebowale Abdul‐Rasaq A. , Sanni Silifat A. , Sobukola Olajide P. , Obadina Adewale O. , Kajihausa Olatundun E. , Adegunwa Mojisola O. , Sanni Lateef O. , Tomlins Keith 
Published: July 2015

AbstractThe study investigated the functional properties of HQYF (high‐quality yam flour) from tubers of four dioscorea species. The tubers were processed into HQYF using two pretreatments (potassium metabisulphite: 0.28%, 15 min; blanching: 70°C, 15 min) and drying methods (cabinet: 60°C, 48 h; sun drying: 3 days). Significant differences (P < 0.05) were observed in pasting characteristics of flours among the four species. The drying method significantly affected only the peak viscosity. The interactive effect of species, pretreatment, and drying methods on the functional properties was significant (P < 0.05) except for emulsification capacity, angle of repose, and least gelation concentration. The significant variation observed in most of the functional properties of the HQYF could contribute significantly to breeding programs of the yam species for diverse food applications. The pastes of flour from Dioscorea dumetorum pretreated with potassium metabisulphite and dried under a cabinet dryer were stable compared to other samples, hence will have better applications in products requiring lower retrogradation during freeze/thaw cycles.
Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus
Authors: Fritz Andrew J. , Barutcu A. Rasim , Martin‐Buley Lori , van Wijnen André J. , Zaidi Sayyed K. , Imbalzano Anthony N. , Lian Jane B. , Stein Janet L. , Stein Gary S. 
Published: July 2015

ABSTRACTThe organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear‐structure building blocks in directly supporting nuclear function in a physiologically responsive manner. J. Cell. Biochem. 117: 9–19, 2016. © 2015 Wiley Periodicals, Inc.
Laser polishing of aluminum by remelting with high energy pulses
Authors: Schmidt J. , Scholz R. , Riegel H. 
Published: July 2015

Laser polishing is a contact‐free, quick and automated method to smooth surfaces. The method has been applied to different forging and casting aluminum alloys. The surfaces of the samples were belt‐grinded with a grain size of mesh 240. The samples are protected from ambient air in a gas shield chamber. The used laser system is an Nd : YAG Laser with maximum pulse energy of 65 J. The initial and the laser polished surfaces have been analyzed by microscopy, roughness spectroscopy, white light interferometry and cross‐section polishes. The surfaces of the laser polished forging alloys are covered by multiple lateral and horizontal cracks. Unlike the forging alloys, the casting alloys could be processed well by laser polishing. The initial surface roughness of Ra240 = 1.37 µm was reduced up to RaLP ≈ 0.47 µm. This represents a roughness reduction of 66%. The roughness spectroscopy of the laser polished surface shows for structural wavelengths from 2.5 µm to 500 µm a Ra‐value close to 0.1 µm and from 500 µm to 800 µm higher values. The remelted area extends up to100 µm into the material.
Characterizing the nature of interactions for cooperative creation in online social networks
Authors: Cazabet Remy , Takeda Hideaki , Hamasaki Masahiro 
Published: July 2015

AbstractMany aspects of online social networks (OSN) have been studied in recent years. In this article, we focus on the question of interactions in large OSN. We propose methods to study these interactions, and apply them on a platform called Nico Nico Douga (NND), with the aim of understanding cooperative behaviors, taking the form of collective creation of music videos in NND. Our first contribution is a method that, starting from the network of interactions between users, evaluates three aspects: the impact of the social structure on these interactions, their concentration, and their reciprocity. We characterize the nature of interactions in NND, and compare it with four different datasets. We find that interactions in NND are more similar to a diffusion process, such as retweets in Tweeter, than to interpersonal communications, or even to cooperation in science. Our second contribution is a typology of roles for productions in a cooperative process. These roles are attributed based on the neighborhood of the nodes in the network of references between productions. We define direct roles, relative roles, and indirect roles. We subsequently study the frequency of these roles in NND. We show a correlation between the category of the contribution of a video (song, animation, etc.) and its probability of having a certain role. We also find a positive correlation between the most active users and the production of videos playing an important role in the cooperation process.
Effects of add-on tipepidine on treatment-resistant depression: an open-label pilot trial
Authors: Shirayama Yukihiko , Suzuki Masatoshi , Takahashi Michio , Sato Koichi , Hashimoto Kenji 
Published: July 2015

ObjectiveTreatment-resistant depression is a challenging problem in the clinical setting. Tipepidine has been used as a non-narcotic antitussive in Japan since 1959.MethodsWe administered tipepidine to 11 patients with treatment-resistant depression. Tipepidine was given for 8 weeks as an augmentation.ResultsTipepidine significantly improved depression scores on the Hamilton Rating Scale for depression. Add-on treatment with tipepidine significantly improved scores on the trail making test and Rey auditory verbal learning test. However, no changes were observed in blood concentrations of stress-related hormones (adrenocorticotropic hormone, cortisol, dehydroepiandrosterone sulphate) with tipepidine augmentation.ConclusionTipepidine might be a potential therapeutic drug for treatment-resistant depression.
Identification of phases, symmetries and defects through local crystallography
Authors: Belianinov Alex , He Qian , Kravchenko Mikhail , Jesse Stephen , Borisevich Albina , Kalinin Sergei V. 
Published: July 2015

AbstractAdvances in electron and probe microscopies allow 10 pm or higher precision in measurements of atomic positions. This level of fidelity is sufficient to correlate the length (and hence energy) of bonds, as well as bond angles to functional properties of materials. Traditionally, this relied on mapping locally measured parameters to macroscopic variables, for example, average unit cell. This description effectively ignores the information contained in the microscopic degrees of freedom available in a high-resolution image. Here we introduce an approach for local analysis of material structure based on statistical analysis of individual atomic neighbourhoods. Clustering and multivariate algorithms such as principal component analysis explore the connectivity of lattice and bond structure, as well as identify minute structural distortions, thus allowing for chemical description and identification of phases. This analysis lays the framework for building image genomes and structure–property libraries, based on conjoining structural and spectral realms through local atomic behaviour.
Generating optical superimposed vortex beam with tunable orbital angular momentum using integrated devices
Authors: Wang Yu , Feng Xue , Zhang Dengke , Zhao Peng , Li Xiangdong , Cui Kaiyu , Liu Fang , Huang Yidong 
Published: July 2015

AbstractAn integrated device, which consists of a variable amplitude splitter and an orbital angular momentum (OAM) emitter, is proposed for the superposition of optical vortex beams. With fixed wavelength and power of incident beam, the OAM of the radiated optical superimposed vortex beam can be dynamically tuned. To verify the operating principle, the proposed device has been fabricated on the SOI substrate and experimentally measured. The experimental results confirm the tunability of superimposed vortex beams. Moreover, the ability of independently varying the OAM flux and the geometric distribution of intensity is illustrated and discussed with numerical simulation. We believe that this work would be promising in various applications.
Surface Termination Conversion during SrTiO3 Thin Film Growth Revealed by X-ray Photoelectron Spectroscopy
Authors: Baeumer Christoph , Xu Chencheng , Gunkel Felix , Raab Nicolas , Heinen Ronja Anika , Koehl Annemarie , Dittmann Regina 
Published: July 2015

AbstractEmerging electrical and magnetic properties of oxide interfaces are often dominated by the termination and stoichiometry of substrates and thin films, which depend critically on the growth conditions. Currently, these quantities have to be measured separately with different sophisticated techniques. This report will demonstrate that the analysis of angle dependent X-ray photoelectron intensity ratios provides a unique tool to determine both termination and stoichiometry simultaneously in a straightforward experiment. Fitting the experimental angle dependence with a simple analytical model directly yields both values. The model is calibrated through the determination of the termination of SrTiO3 single crystals after systematic pulsed laser deposition of sub-monolayer thin films of SrO. We then use the model to demonstrate that during homoepitaxial SrTiO3 growth, excess Sr cations are consumed in a self-organized surface termination conversion before cation defects are incorporated into the film. We show that this termination conversion results in insulating properties of interfaces between polar perovskites and SrTiO3 thin films. These insights about oxide thin film growth can be utilized for interface engineering of oxide heterostructures. In particular, they suggest a recipe for obtaining two-dimensional electron gases at thin film interfaces: SrTiO3 should be deposited slightly Ti-rich to conserve the TiO2-termination.
Atlantic Deep-water Response to the Early Pliocene Shoaling of the Central American Seaway
Authors: Bell David B. , Jung Simon J. A. , Kroon Dick , Hodell David A. , Lourens Lucas J. , Raymo Maureen E. 
Published: July 2015

AbstractThe early Pliocene shoaling of the Central American Seaway (CAS), ~4.7–4.2 million years ago (mega annum-Ma), is thought to have strengthened Atlantic Meridional Overturning Circulation (AMOC). The associated increase in northward flux of heat and moisture may have significantly influenced the evolution of Pliocene climate. While some evidence for the predicted increase in North Atlantic Deep Water (NADW) formation exists in the Caribbean and Western Atlantic, similar evidence is missing in the wider Atlantic. Here, we present stable carbon (δ13C) and oxygen (δ18O) isotope records from the Southeast Atlantic-a key region for monitoring the southern extent of NADW. Using these data, together with other δ13C and δ18O records from the Atlantic, we assess the impact of the early Pliocene CAS shoaling phase on deep-water circulation. We find that NADW formation was vigorous prior to 4.7 Ma and showed limited subsequent change. Hence, the overall structure of the deep Atlantic was largely unaffected by the early Pliocene CAS shoaling, corroborating other evidence that indicates larger changes in NADW resulted from earlier and deeper shoaling phases. This finding implies that the early Pliocene shoaling of the CAS had no profound impact on the evolution of climate.
Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells
Authors: Lopes José Pedro , Stylianou Marios , Nilsson Gunnar , Urban Constantin F. 
Published: July 2015

AbstractImmunosuppressed patients are frequently afflicted with severe mycoses caused by opportunistic fungal pathogens. Besides being a commensal, colonizing predominantly skin and mucosal surfaces, Candida albicans is the most common human fungal pathogen. Mast cells are present in tissues prone to fungal colonization being expectedly among the first immune cells to get into contact with C. albicans. However, mast cell-fungus interaction remains a neglected area of study. Here we show that human mast cells mounted specific responses towards C. albicans. Collectively, mast cell responses included the launch of initial, intermediate and late phase components determined by the secretion of granular proteins and cytokines. Initially mast cells reduced fungal viability and occasionally internalized yeasts. C. albicans could evade ingestion by intracellular growth leading to cellular death. Furthermore, secreted factors in the supernatants of infected cells recruited neutrophils, but not monocytes. Late stages were marked by the release of cytokines that are known to be anti-inflammatory suggesting a modulation of initial responses. C. albicans-infected mast cells formed extracellular DNA traps, which ensnared but did not kill the fungus. Our results suggest that mast cells serve as tissue sentinels modulating antifungal immune responses during C. albicans infection. Consequently, these findings open new doors for understanding fungal pathogenicity.
The impact of culture on the construal of organizational crisis: perceptions of crisis in Dubai
Authors: Goby Valerie  Priscilla , Nickerson Catherine 
Published: July 2015

Purpose
– Despite the rising significance of the Arabian Gulf on the global corporate landscape, research is lacking in the area of organizational crisis communication. The purpose of this paper is to present a preliminary contribution to this gap in the form of an initial investigation of the conceptualization of crisis among female Emirati nationals in Dubai.

Design/methodology/approach
– With reference to Pearson and Clair’s (1998) list of organizational crises, the authors designed a survey to elicit perceptions of crises, their severity, and their likelihood of occurring in the United Arab Emirates; the authors administered this survey to 105 female Emirati respondents. Given the heavy delineation of gender roles that exists in the region, the authors limited this initial study to a single gender, women. The authors discuss the crises respondents identified as most severe and most likely to occur in the country in terms of culture, Islamic values, and business in Dubai.

Findings
– Responses indicate that perceptions of crisis differ vastly from those that typically obtain in western countries and that particular religious and cultural factors influence these perceptions.

Research limitations/implications
– Given the divergence between the construal of crisis in the Gulf and in western contexts, further investigation of how organizational crisis is perceived and responded to in Gulf contexts is warranted to inform corporate communication management in a region whose economic influence is increasingly important. Future research also needs to investigate a broader sample, including male respondents, in order to construct a framework of culture and crisis in the region.

Practical implications
– As more MNCs are attracted to Dubai, and other Gulf cities, it is imperative that they are well informed of the differing perceptions of, and reactions to, potential crises that may affect them directly or indirectly.

Originality/value
– The present study is the first the authors know of that assesses how organizational crises are perceived in a Gulf context. It brings to the fore certain particularities that could serve as hypotheses for an innovative research stream. While it is an exploratory study, it highlights salient issues that can be formulated into hypotheses in further research.
Market orientation, entrepreneurial orientation and performance in emerging markets
Authors: Gruber-Muecke Tina , Hofer Katharina Maria 
Published: July 2015

Purpose
– The purpose of this paper is to examine how market-oriented and entrepreneurial-oriented behaviour drives firm performance in an emerging markets context.

Design/methodology/approach
– Using data from 170 Austrian exporters to Central and Eastern Europe, the authors test a conceptual model including market-oriented and entrepreneurial-oriented practices as predictors of performance.

Findings
– Results indicate that both market-orientated and entrepreneurial-oriented strategies have positive performance effects in emerging markets.

Research limitations/implications
– A limitation is that firms were not examined longitudinally, as this is a cross-sectional study. Future research may include longitudinal studies or focus on other markets/regions.

Practical implications
– Firms are encouraged to adopt a market-oriented and entrepreneurial-oriented strategy to achieve better results in international, emerging market operations.

Originality/value
– The authors add to the emerging economy research literature by studying the relevance of market orientation and entrepreneurial orientation in determining firm performance in emerging markets. Furthermore, this study supports the generalizability of findings from an advanced to an emerging economies research setting.
Clinical pharmacist review: A randomised controlled trial
Authors: Briggs Sheridan , Pearce Robert , Dilworth Sophie , Higgins Isabel , Hullick Carolyn , Attia John 
Published: July 2015

AbstractObjectivesTo determine if medication review by a clinical pharmacist of older patients in the ED impacted on admission to hospital and other outcomes.MethodsA stratified, randomised controlled study comparing the intervention to current practice. A tertiary referral ED in New South Wales, Australia. Older people (>70 years) living at home who initially reported taking greater than five medications. Medication review by an experienced hospital pharmacist within the ED. Rate of admission, rate of readmission, length of stay and admission to an aged care facility at 4 months post presentation, and rate of general practitioner acceptance of pharmacist recommendations.ResultsThe odds of admission decreased for those receiving the intervention (odds ratio [OR] = 0.68, 95% confidence interval [CI]: 0.53, 0.87; P = 0.002). There was no evidence that the intervention affected hospital length of stay for admitted patients (0.09 days change, 95% CI −0.08, 0.25; P = 0.31), the rate of re‐presentation (0.08% change, 95% CI −0.12, 0.28; P = 0.44) or admission to an aged care facility. The odds of admission to an aged care facility increased with the Identification of Seniors at Risk score. General practitioners adopted 49% of pharmacists' recommendations.ConclusionsThe presence of an experienced pharmacist in the ED reduced hospital admissions. Further study is required to determine longer term impacts of General Medical Practitioner acceptance of pharmacists' recommendations.
Detection of prostate cancer index lesions with multiparametric magnetic resonance imaging (mp‐MRI) using whole‐mount histological sections as the reference standard
Authors: Russo Filippo , Regge Daniele , Armando Enrico , Giannini Valentina , Vignati Anna , Mazzetti Simone , Manfredi Matteo , Bollito Enrico , Correale Loredana , Porpiglia Francesco 
Published: July 2015

ObjectiveTo evaluate the sensitivity of multiparametric magnetic resonance imaging (mp‐MRI) for detecting prostate cancer foci, including the largest (index) lesions.Patients and MethodsIn all, 115 patients with biopsy confirmed prostate cancer underwent mp‐MRI before radical prostatectomy. A single expert radiologist recorded all prostate cancer foci including the index lesion ‘blinded’ to the pathologist's biopsy report. Stained whole‐mount histological sections were used as the reference standard. All lesions were contoured by an experienced uropathologist who assessed their volume and pathological Gleason score. All lesions with a volume of >0.5 mL and/or pathological Gleason score of >6 were defined as clinically significant prostate cancer. Multivariate analysis was used to ascertain the characteristics of lesions identified by MRI.ResultsIn all, 104 of 115 index lesions were correctly diagnosed by mp‐MRI (sensitivity 90.4%; 95% confidence interval [CI] 83.5–95.1%), including 98/105 clinically significant index lesions (93.3%; 95% CI 86.8–97.3%), among which three of three lesions had a volume of <0.5 mL and Gleason score of >6. Overall, mp‐MRI detected 131/206 lesions including 13 of 68 ‘insignificant’ prostate cancers. The multivariate logistic regression modelling showed that pathological Gleason score (odds ratio [OR] 11.7, 95% CI 2.3–59.8; P = 0.003) and lesion volume (OR 4.24, 95% CI 1.3–14.7; P = 0.022) were independently associated with the detection of index lesions at MRI.ConclusionsThis study shows that mp‐MRI has a high sensitivity for detecting clinically significant prostate cancer index lesions, while having disappointing results for the detection of small‐volume, low Gleason score prostate cancer foci. Thus, mp‐MRI could be used to stratify patients according to risk, allowing better treatment selection.