bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammographic features differ with body composition in women with breast cancer
Authors: Sartor Hanna , Sturesdotter Li , Larsson Anna-Maria , Rosendahl Ann H. , Zackrisson Sophia 
Published: July 2024

Abstract
Objectives
There are several breast cancer (BC) risk factors—many related to body composition, hormonal status, and fertility patterns. However, it is not known if risk factors in healthy women are associated with specific mammographic features at the time of BC diagnosis. Our aim was to assess the potential association between pre-diagnostic body composition and mammographic features in the diagnostic BC image.

Materials and methods
The prospective Malmö Diet and Cancer Study includes women with invasive BC from 1991 to 2014 (n = 1116). BC risk factors at baseline were registered (anthropometric measures, menopausal status, and parity) along with mammography data from BC diagnosis (breast density, mammographic tumor appearance, and mode of detection). We investigated associations between anthropometric measures and mammographic features via logistic regression analyses, yielding odds ratios (OR) with 95% confidence intervals (CI).

Results
There was an association between high body mass index (BMI) (≥ 30) at baseline and spiculated tumor appearance (OR 1.370 (95% CI: 0.941–2.010)), primarily in women with clinically detected cancers (OR 2.240 (95% CI: 1.280–3.940)), and in postmenopausal women (OR 1.580 (95% CI: 1.030–2.440)). Furthermore, an inverse association between high BMI (≥ 30) and high breast density (OR 0.270 (95% CI: 0.166–0.438)) was found.

Conclusion
This study demonstrated an association between obesity and a spiculated mass on mammography—especially in women with clinically detected cancers and in postmenopausal women. These findings offer insights on the relationship between risk factors in healthy women and related mammographic features in subsequent BC.

Clinical relevance statement
With increasing numbers of both BC incidence and women with obesity, it is important to highlight mammographic findings in women with an unhealthy weight.

Key Points

Women with obesity and BC may present with certain mammographic features.

Spiculated masses were more common in women with obesity, especially postmenopausal women, and those with clinically detected BCs.

Insights on the relationship between obesity and related mammographic features will aid mammographic interpretation.
Clinical relevance of the 3-cm threshold in sigmoid diverticulitis with abscess: consensus or quandary?
Authors: Vaghiri Sascha , David Stephan Oliver , Sultani Ahmad Baktash , Safi Sami Alexander , Knoefel Wolfram Trudo , Prassas Dimitrios 
Published: July 2024

Abstract
Purpose
Diverticular abscess is a common manifestation of acute complicated diverticulitis. We aimed to analyze the clinical course of patients with diverticular abscess initially treated conservatively.

Methods
All patients with diverticular abscess undergoing elective or urgent/emergency surgery from October 2004 to October 2022 were identified from our institutional database. Depending on the abscess size, patients were divided into group A (≤ 3 cm) and group B (> 3 cm). Conservative treatment failure was defined as clinical deterioration, persistent or recurrent abscess, or urgent/emergency surgery. Baseline characteristics and short-term perioperative outcomes were recorded and compared between both groups. Uni- and multivariate analyses were conducted to identify determinants of conservative treatment failure and overall ostomy formation.

Results
A total of 105 patients were enrolled into group A (n = 73) and group B (n = 32). Uni- and multivariate analyses revealed abscess size as the only significant factor of conservative therapy failure [OR 9.904; p < 0.0001], while overall ostomy formation was significantly affected by an increased body mass index (BMI) [OR 1.366; p = 0.026]. There were no significant differences in perioperative outcome with the exception of a longer total hospital stay in patients managed with abscess drainage compared to antibiotics alone prior surgery in group B (p = 0.045).

Conclusion
Abscess diameter > 3 cm is not just an arbitrary chosen cut-off value for drainage placement but has a prognostic impact on medical treatment failure in patients with complicated acute diverticulitis. In this subgroup, the choice between primary drainage and antibiotics does not appear to influence outcome at the cost of prolonged hospital stay after drainage insertion.
Disparities in glaucoma and macular degeneration healthcare utilization among persons living with dementia in the United States
Authors: Hamedani Ali G. , Chang Angela Y. , Chen Yineng , VanderBeek Brian L. 
Published: July 2024

Abstract
Purpose
Dementia is common among patients with primary open angle glaucoma (POAG) and neovascular age-related macular degeneration (nAMD). This study compares visit frequency, diagnostic test utilization, and treatment patterns for POAG and nAMD among persons with vs. without dementia.

Methods
Optum’s de-identified Clinformatics® Data Mart Database (January 1, 2000-June 30, 2022) was used for this study. Two cohorts were created from newly diagnosed POAG or nAMD patients. Within each cohort, an exposure cohort was created of newly diagnosed dementia patients. The primary outcome was the number of visits to an eye care provider. Secondary analyses for the POAG cohort assessed the number of visual field tests, optical coherence tomography (OCT), and glaucoma medication prescription coverage. The secondary analysis for the nAMD cohort included the number of injections performed. Poisson regression was used to determine the relative rates of outcomes.

Results
POAG patients with dementia had reduced rates of eye care visits (RR 0.76, 95% CI: 0.75–0.77), lower rates of testing utilization for visual fields (RR 0.66, 95% CI: 0.63–0.68) and OCT (RR 0.67, 95% CI: 0.64–0.69), and a lower rate of glaucoma prescription medication coverage (RR 0.83, 95% CI: 0.83–0.83). nAMD patients with dementia had reduced rates of eye care visits (RR 0.74, 95% CI: 0.70–0.79) and received fewer intravitreal injections (RR 0.64, 95% CI: 0.58–0.69) than those without dementia.

Conclusions
POAG and nAMD patients with dementia obtained less eye care and less monitoring and treatment of their disease. These findings suggest that this population may be vulnerable to gaps in ophthalmic care.
Effects of air pollution on global health: evidence from the global burden of disease study in the BRICS countries
Authors: Behera Deepak Kumar , Viswanathan Pozhamkandath Karthiayani , Mishra Sanghamitra 
Published: July 2024

Abstract
Purpose
Considering the dynamic influence of environmental, social, economic, and political factors in the emergence and growth of the BRICS countries (Brazil, Russia, India, China, and South Africa) over the years and pre-existing differences, the adverse effects of air pollution on the health and well-being of the people have remained major areas of academic inquiry and policy interventions. The present study examines the global trend of deaths and Disability Adjusted Life Years (DALYs) attributable to air pollution with particular reference to the BRICS countries for the period 1990 to 2019.

Methods
This study has used the global burden of disease estimates by using different rounds of the Global Burden of Disease (GBD) study report published by the Institute of Health Metrics Evaluation. This study has calculated the cause of death and DALYs due to environmental risk factors (i.e. Air pollution). Data analysis has been done by using the standard formula for the calculation of death (mortality) rate and DALYs rate. Similarly, we calculated the age and gender-wise death and DALYs rate by using the appropriate numerator and denominator.

Results
The study discovered a significant shift in disease patterns over this period, as communicable diseases like respiratory infections and tuberculosis were replaced by non-communicable diseases such as ischemic heart disease (17.2 million), chronic obstructive pulmonary disease (14.59 million), and stroke (17.02 million) as the primary causes of air pollution-related deaths in 2019 at the global level. Additionally, the study identified a worrying increase in deaths linked to neonatal disorders and respiratory infections caused by ambient particulate matter pollution in South Africa, India, and Brazil. The impact of air pollution on public health is evident across different age groups and genders, with people aged 50-69 years, those aged 70 and above, and children under 5 years being more vulnerable. Furthermore, the male population is disproportionately affected by communicable and noncommunicable diseases caused by air pollution.

Conclusion
The study highlights the need for policymakers to implement evidence-based interventions to tackle this global health problem. The interventions should aim to reduce the emerging crisis of non-communicable diseases related to air pollution, particularly among vulnerable age groups and the male population, ultimately improving public health outcomes.
Patient attitudes and experiences towards exercise during oncological treatment. A qualitative systematic review
Authors: Finch Alice , Benham Alex 
Published: July 2024

Abstract
Purpose
Exercise and physical activity (PA) during oncological treatment have many benefits. However, PA levels and adherence are often low. This systematic review of qualitative literature aims to explore the experience and the perceived barriers and facilitators to exercise and physical activity during treatment.

Methods
A systematic search of the published literature was carried out in the Embase and Medline databases; full details for the protocol can be found in the Prospero database (CRD42022371206). Studies eligible for inclusion were qualitative and included participants that were either currently undergoing oncological treatment or had finished treatment within the last 6 months. The findings from each study were tabulated and synthesised into analytical themes.

Results
Eighteen full texts from 309 studies met inclusion criteria with a total of 420 participants including both curative and palliative treatment intents. Four overarching themes were generated: (1) Facilitators; (2) Barriers; (3) Experience of PA/exercise and (4) Transforming attitudes. Sub-themes that showed perceptions of PA or exercise during treatment were positive, and seeing personal positive change was highly motivating, especially in a group class setting. Barriers included lack of support or guidance from healthcare professionals (HCPs), environmental challenges and disease burden/fear or worsening symptoms.

Conclusions
Despite having positive perceptions of exercise and PA during oncological treatment, there are significant barriers impacting participation. Lack of support from HCPs and fear of worsening symptoms were significant barriers. Future research should focus on impacting these barriers to ultimately improve PA and exercise levels in those undergoing oncological treatment.
A note on structural mode transitions in buckling of radially stretched annular plates
Authors: Rammerstorfer Franz G. 
Published: July 2024

AbstractThe different approximating assumptions used in deriving models for structural analysis by dimensional reduction of a 3d continuum to structural components like beams and plates or shells limit the applicability of these models by geometrical constraints. Hence, caution should be exercised when transitioning from the application range of one type of structure model to another one. This should be taken into account especially when stability analyses are performed. In order to demonstrate this, in this note, buckling of annular plates under tensile loading at the inner edge is treated as an example. The ratio between inner and outer radius is varied. For ratios approaching 1.0, plate buckling turns into buckling of circular beams. This is not only a question of accuracy of the solution but can lead to a substantial qualitative change of the character of buckling. Such considerations might be interesting from a theoretical point of view; in any case they are important from the engineering point of view.
Comparative genomics of Vibrio toranzoniae strains
Authors: Barcia-Cruz Rubén , Balboa Sabela , Lema Alberto , Romalde Jesús L. 
Published: July 2024

AbstractVibrio toranzoniae is a marine bacterium belonging to the Splendidus clade that was originally isolated from healthy clams in Galicia (NW Spain). Its isolation from different hosts and seawater indicated two lifestyles and wide geographical distribution. The aim of the present study was to determine the differences at the genomic level among six strains (4 isolated from clam and 2 from seawater) and to determine their phylogeny. For this purpose, whole genomes of the six strains were sequenced by different technologies including Illumina and PacBio, and the resulting sequences were corrected. Genomes were annotated and compared using different online tools. Furthermore, the study of core- and pan-genomes were examined, and the phylogeny was inferred. The content of the core genome ranged from 2953 to 2766 genes and that of the pangenome ranged from 6278 to 6132, depending on the tool used. Although the strains shared certain homology, with DDH values ranging from 77.10 to 82.30 and values of OrthoANI values higher than 97%, some differences were found related to motility, capsule synthesis, iron acquisition systems or mobile genetic elements. Phylogenetic analysis of the core genome did not reveal a differentiation of the strains according to their lifestyle (commensal or free-living), but that of the pangenome indicated certain geographical isolation in the same growing area. This study led to the reclassification of some isolates formerly described as V. toranzoniae and demonstrated the importance of cured deposited sequences to proper phylogenetic assignment.
A sparse spectral method for fractional differential equations in one-spatial dimension
Authors: Papadopoulos Ioannis P. A. , Olver Sheehan 
Published: July 2024

AbstractWe develop a sparse spectral method for a class of fractional differential equations, posed on $$\mathbb {R}$$
R
, in one dimension. These equations may include sqrt-Laplacian, Hilbert, derivative, and identity terms. The numerical method utilizes a basis consisting of weighted Chebyshev polynomials of the second kind in conjunction with their Hilbert transforms. The former functions are supported on $$[-1,1]$$

[
-
1
,
1
]

whereas the latter have global support. The global approximation space may contain different affine transformations of the basis, mapping $$[-1,1]$$

[
-
1
,
1
]

to other intervals. Remarkably, not only are the induced linear systems sparse, but the operator decouples across the different affine transformations. Hence, the solve reduces to solving K independent sparse linear systems of size $$\mathcal {O}(n)\times \mathcal {O}(n)$$

O
(
n
)
×
O
(
n
)

, with $$\mathcal {O}(n)$$

O
(
n
)

nonzero entries, where K is the number of different intervals and n is the highest polynomial degree contained in the sum space. This results in an $$\mathcal {O}(n)$$

O
(
n
)

complexity solve. Applications to fractional heat and wave equations are considered.
A review of digital twins and their application in cybersecurity based on artificial intelligence
Authors: Homaei Mohammadhossein , Mogollón-Gutiérrez Óscar , Sancho José Carlos , Ávila Mar , Caro Andrés 
Published: July 2024

AbstractThe potential of digital twin technology is yet to be fully realised due to its diversity and untapped potential. Digital twins enable systems’ analysis, design, optimisation, and evolution to be performed digitally or in conjunction with a cyber-physical approach to improve speed, accuracy, and efficiency over traditional engineering methods. Industry 4.0, factories of the future, and digital twins continue to benefit from the technology and provide enhanced efficiency within existing systems. Due to the lack of information and security standards associated with the transition to cyber digitisation, cybercriminals have been able to take advantage of the situation. Access to a digital twin of a product or service is equivalent to threatening the entire collection. There is a robust interaction between digital twins and artificial intelligence tools, which leads to strong interaction between these technologies, so it can be used to improve the cybersecurity of these digital platforms based on their integration with these technologies. This study aims to investigate the role of artificial intelligence in providing cybersecurity for digital twin versions of various industries, as well as the risks associated with these versions. In addition, this research serves as a road map for researchers and others interested in cybersecurity and digital security.
Physiological responses of invasive round goby (Neogobius melanostomus) to environmental stressors across a latitudinal span
Authors: Błońska Dagmara , Janic Bartosz , Tarkan Ali Serhan , Piria Marina , Bănăduc Doru , Švolíková Kristína Slovák , Števove Barbora , Lappalainen Jyrki , Pyrzanowski Kacper , Tszydel Mariusz , Bukowska Bożena 
Published: July 2024

AbstractEcosystems worldwide are struggling with increasingly high levels of human-induced stressors, impacting their ecological health at local, regional, and global scales. Among the factors affecting freshwater organisms, temperature stands out, especially given the recent escalation of global warming, with possible adverse effects. In this study, we examined the basal levels of oxidative stress parameters in the round goby Neogobius melanostomus, spanning its native and non-native ranges of occurrence. We aimed to assess five populations across transcontinental scale (Turkey, Croatia, Slovakia, Poland, Finland) to determine whether individuals already experiencing conditions other than their thermal optimum (such as those in Turkey and Finland) would display elevated non-enzymatic indicators (level of lipid peroxidation and reduced glutathione levels) and enzymatic indicators (activity of glutathione peroxidase and catalase activity) of oxidative stress compared to those inhabiting milder ecosystems. The results obtained did not align with our initial predictions. The native Turkish population exhibited the lowest values for both antioxidants and oxidative damage, indicating an efficient redox system in this species. All tested parameters showed variation among populations, as well as between tissues and sexes. Temperature did not emerge as significant factor in any of the parameters tested, while for glutathione peroxidase, our analysis indicated a positive relationship with enzyme activity and salinity. The lack of a continuous latitudinal pattern in the non-native populations suggests the species’ potential for adaptive shifts, indicating superior adaptive abilities, especially in human affected ecosystems, rather than strictly adhering to environmental gradients.
Variation in ecological scorecards and their potential for wider use
Authors: Gorman Thomas , Kindermann Gesche , Healy Kevin , Morley Terry R. 
Published: July 2024

AbstractEcological monitoring is a vital tool to help us assess habitat condition and understand the mechanism(s) for habitat change. Yet many countries struggle to meet their monitoring requirements in part due to the high assessment workload. Rapid ecological assessment methods may have an important role to play in this regard. Following their success within several European habitats (e.g., semi-natural grasslands), they are now being developed for additional habitats such as heathlands, peatlands, and other agri-associated areas. Whilst some rapid assessments using ecological scorecards have been shown to be accurate compared to traditional ecological monitoring, less is known about the functionality of these scorecards in heterogenous landscapes. In this study, we selected four existing scorecards to test alongside a prototype. We assessed how these different scorecards measured habitat condition on the same heathland sites. We found that the choice of metrics, their score weighting, and the thresholds used for categorical scores cause scorecards to assess the same site with substantial variation (37%). Vegetation metrics were the primary cause of score variation, with vegetation structure and positive indicator species being the leading causes. Our study indicates that whilst current scorecards may be representative of project-specific goals, they may not be suitable for wider monitoring uses in their current form. Ecological scorecards have great potential to drastically increase the extent of monitoring, but caution is needed before adapting existing scorecards beyond the purposes from which they were designed.
Who is Mobilized to Vote by Short Text Messages? Evidence from a Nationwide Field Experiment with Young Voters
Authors: Hirvonen Salomo , Lassander Maarit , Sääksvuori Lauri , Tukiainen Janne 
Published: July 2024

Abstract
Using a large randomized controlled trial and rich individual-level data on eligible voters and their household members, we evaluate how get-out-the-vote (GOTV) appeals affect inequalities in voting, transmit from treated to untreated individuals within households, and how the transmission of voting decisions through family networks influences inequalities in voting. We find that receiving a text message reminder before the Finnish county elections in 2022 mobilized mainly low-propensity voters. As a result, the GOTV intervention reduced existing social inequalities in voting within the target group of young voters. We remarkably find that over 100% of the direct treatment effect spilled over to untreated household members. These spillovers reduced inequality in political participation among the older voters who were not part of the target group. Overall, our results exemplify how randomized controlled trials with a limited focus on the analysis of individuals in the treatment and control groups alone may lead to misestimating the compositional effects of get-out-the-vote interventions.
Carbon emission reduction and hydrogen production maximization from carbon emission-based hydrogen sources
Authors: Abifarin Johnson Kehinde , Abifarin Fredah Batale 
Published: July 2024

AbstractThis study aims to optimize hydrogen (H2) production via ethanol steam reforming (ESR) and water gas shift reaction (WGSR) pathways, focusing on minimizing CO, CO2, and CH4 emissions while maximizing H2 yield. Employing Taguchi grey relational analysis, we investigate the intricate balance between production conditions and multi-response gas generation. Utilizing Origin Pro software, regression modeling forecasts individual and overall gas generation. Our analysis identifies optimal conditions: a feed liquid flow rate of 2 mL/min, water-to-carbon ratio of 3, ESR temperature of 300 °C, and WGSR temperature of 350 °C. These conditions promise clean, efficient H2 production. Key results show the water-to-carbon ratio and ESR temperature contributing 59.22% and 32.69% to production conditions’ impact, respectively. Graphical and mathematical models validate these findings. Moving forward, further experimental validation of optimal conditions for multi-response gas generation is recommended. This study pioneers a transformative approach towards sustainable, environmentally friendly H2 production.