bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomically Dispersed Interstitial Phosphorus Boosts Alkaline Hydrogen Evolution Performance of Co Catalysts
Authors: Shi Yue , Wang Mengna , Zhang Dan , Li Hongdong , Li Caixia , Zhan Tianrong , Lai Jianping , Wang Lei 
Published: August 2024

AbstractIntroducing interstitial light atoms shows great potential in improving the intrinsic activity and stability of metal catalysts owing to strongly affecting the electronic structure and adsorption properties. However, filling atomically dispersed light atoms into metal lattices and further unveiling their interstitial effects are still limited by tightly arranged metal lattices. Herein, the study reports a calcination reduction assisted trace light atoms filling strategy to form a series of interstitial light single atoms filled Co‐based catalysts (Co‐X@NF, X = P, N and NF = nickel foam), therefore constructing monometallic atomic interfaces between P‐coordinated Coδ+ and Co0 to promote alkaline hydrogen evolution reaction (HER). Noteworthy, the optimal Co‐P0.43@NF with rich monometallic atomic interfacial structure shows very high turnover frequency values (5.64 s−1), which is close to noble metal level and far exceeds non‐noble metal catalysts. Meanwhile, it maintains excellent stability of 150 h at 100 mA cm−2. Theoretical studies prove that P‐coordinated Coδ+ promotes H2O dissociation and Co0 optimizes H* adsorption energy, thus forming highly active monometallic atomic interfaces, which greatly accelerates the alkaline HER kinetics.
Surface‐Confined Winding Assembly of SiO2 on the Surface of BaTiO3 Leading to Enhanced Performance of Dielectric Nanocomposites
Authors: Wang Fan , Luo Hang , Chen Haiyan , Zhai Di , Jiang Xun , Liu Yuan , Zhang Dou 
Published: August 2024

AbstractIn response to the demand for miniaturization and lightweighting in the electronics industry, achieving enhanced energy density of dielectrics is crucial. Constructing nanocomposites consist of ceramic fillers and polymer matrix is an effective strategy in this regard. To address the adverse coupling between polarization and breakdown strength of the nanocomposites, a series of BaTiO3@SiO2 nanofillers with customizable SiO2 shell coverage degrees (90°, 180°, and 360°) is designed and synthesized by surface‐confined winding assembly of SiO2 on the surface of BaTiO3. When a half area of BaTiO3 core is coated by SiO2 layer, it is defined as 180°. A larger coverage degree implies better reduction of leakage current injection, and more effective suppression of local electric field concentration. However, it also leads to a more pronounced reduction in the polarization. 180° BaTiO3@SiO2 demonstrates the most effective mitigation of the adverse coupling between polarization and breakdown strength in nanocomposites. The 180° BaTiO3@SiO2/Poly(vinylidene fluoride) (PVDF) nanocomposite achieves high breakdown strength while maintaining relatively higher polarization intensity, for example, the energy density reaches 20.64 J cm−3 at 650 MV m−1, which is 2.62 times of pure PVDF. This work reveals the growth mechanism of customizable SiO2 shell coverage degrees on BaTiO3 surfaces, providing an effective strategy for high‐performance dielectrics
Asymmetric π‐Bridge Strategy Regulating Film‐Forming Kinetics for Over 19% Efficiency Organic Solar Cells
Authors: Wang Pengchao , Bi Fuzhen , Jiang Huanxiang , Wang Xiaoning , Cui Chuanlong , Li Yonghai , Bao Xichang 
Published: August 2024

AbstractBlending morphologies are critical to bulk‐heterojunction (BHJ) organic solar cells (OSCs) to realize satisfactory photovoltaic performance. Therefore, rationally manipulating film‐forming kinetics is of great importance to building suitable phase‐separations to balance exciton dissociation and charge transport. Herein, by employing a unilateral π‐bridge approach, a new acceptor, WA6 is reported to optimize the film‐forming process of active layers and their microstructures. Meanwhile, the possible influencing factors are proposed, including intermolecular electrostatic interactions and donor/acceptor compatibility in the vital solution‐to‐film transformation stage. Beneficial from the appropriate fibrous phase‐separation, the PM6:WA6 based solar cells refined exciton/charge properties, leading to 15.39% high efficiency and much greater than the control device based on the counterpart acceptor without π‐bridge. Furthermore, the WA6 can serve as efficient guest component as well, and achieved 19.21% efficiency in the resultant ternary solar cells. This study provides a feasible approach to modulate the molecular aggregation and film‐forming procedure, for the construction of high‐performance OSCs with eligible blending morphologies.
Rapid Hole Transfer and Molecular Enrichment at Amorphous‐Crystalline Interfaces of Pt0.25%/TO(B)‐FCP for Efficient Photocatalysis
Authors: Sun Qimeng , Xia Xiaoyong , He Weijie , Liu Xiaofang , Chen Dongyun , Li Hua , Li Najun , Dong Huilong , Xu Qingfeng , Lu Jianmei 
Published: August 2024

AbstractThe construction of amorphous‐crystalline interfaces of heterogeneous metal oxide systems is an effective approach to modulate the interfacial adsorption behavior and carrier transfer pathways for the photocatalytic process. In this work, the amorphous‐crystalline interface is constructed by covalently linking a flexible crosslinked polymer (FCP) layer to a Pt0.25%/TO(B) substrate. Adsorption‐photodegradation experiments show that Pt0.25%/TO(B)‐FCP can ultimately enrich bisphenol A molecules to the interface within 5 min and in situ‐photodegrade >97.0% of bisphenol A within 10 min (50 ppm), which is 6.21 times than pure TO(B). In addition to the efficient accumulation of BPA molecules, the rapid hole transfer pathway at the amorphous‐crystalline interface is revealed by theoretical calculations, Kelvin probe force microscopy, and photoelectrochemical characterization. The coexistence of Pt single atoms (SAs) and nanoclusters (NCs) optimizes the transfer kinetics and reduces the energy barrier of photogenerated holes of TO(B). Meanwhile, the covalent hole transfer channels between the FCP layer and Pt0.25%/TO(B) significantly accelerate the separation and transfer of photogenerated carrier, promoting the photodegradation of adsorbed BPA molecules.
Self‐Assembled Peptide Hydrogels Loaded with Umbilical Cord‐Derived Mesenchymal Stem Cells Repairing Injured Endometrium and Restoring Fertility
Authors: Lv Xue , Niu Wenjing , Zhang Bin , Chen Jingbo , Yang Shicong , Xue Yuhuan , Dong Yutian , Yuan Peiyan , Pan Yue , Tan Jeremy , Yang Yi Yan , Ding Xin , Zhao Xiaomiao 
Published: August 2024

AbstractEndometrial injury is a major cause of infertility and recurrent miscarriage. However, no clinically available methods currently exist to effectively repair the damaged endometrium. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach for promoting tissue regeneration, yet a biocompatible scaffold capable of delivering MSCs and supporting their growth is needed. Herein, the study reports a peptide hydrogel scaffold, self‐assembled from a peptide IVK8‐RGD consisting of an ionic complementary peptide sequence IEVEIRVK and a bioactive sequence RGD, to load umbilical cord‐derived mesenchymal stem cells (UC‐MSCs). This peptide forms a hydrogel under the physiological condition through self‐assembly, and the peptide hydrogel exhibits injectability and adhesiveness to uterus, making it suitable for endometrial repair. Importantly, this hydrogel supports the adhesion and proliferation of UC‐MSCs in a 3D environment. In vivo experiments using rats with endometrial injury have shown that treatment with IVK8‐RGD hydrogel loaded with UC‐MSCs effectively restores endometrial thickness, inhibits fibrosis, and facilitates angiogenesis through activating Raf/MEK/ERK pathway, leading to significantly improved fertility and live birth rate. These findings demonstrate the potential of the UC‐MSCs‐loaded hydrogel in repairing damaged endometrium and may address the unmet clinical needs of treating recurrent miscarriage and infertility induced by endometrial damage.
Immunometabolic Approaches Mitigating Foreign Body Response and Transcriptome Characterization of the Foreign Body Capsule
Authors: Macias Sabrina L. , Palmer Olivia , Simonovich Jennifer A. , Clark Ryan A. , Hudalla Gregory A. , Keselowsky Benjamin G. 
Published: August 2024

AbstractDirecting immunometabolism presents new opportunities to modulate key cell types associated with the formation of foreign body response (FBR) capsule. Contrasting approaches directing immunometabolism are investigated to mitigate FBR: a broadly suppressive metabolic inhibitor (MI) cocktail comprised of 2‐deoxyglucose (2‐DG), metformin, and 6‐diazo‐5‐oxo‐l‐norleucine (DON) with daily systemic dosing regimen, and local weekly injection of the more narrowly focused tryptophan catabolizing IDO‐Gal3 fusion protein. Treatments significantly decrease FBR capsule formed around subcutaneously implanted cellulose disks. MI cocktail results in a substantially thinner FBR capsule (40% of control), while weekly local injection of IDO‐Gal3 also results in a thinner FBR capsule (69% of control). RNA‐sequencing capsule transcripts reveal MI cocktail promotes quiescence, with decreased antigen processing and presentation, T helper subset differentiation, and cytokine‐cytokine receptor pathway. IDO‐Gal3 promotes pro‐regenerative, alternatively activated M2‐like macrophages and T helper 2 cells, with increased expression of type 2 response‐associated genes (Il4, Il13, Arg1, Mrc1, Chil3, Gata3). IDO‐Gal3 decreases pro‐inflammatory innate sensing pathways, and C‐type lectin receptor, NOD‐like receptor, RIG‐I‐like receptor, and Toll‐like receptor signaling. This work helps define key gene targets and pathways concomitantly regulated in the FBR capsule during immunometabolic modulation compared to control FBR capsule.
Ruthenium Single‐Atom Modulated Protonated Iridium Oxide for Acidic Water Oxidation in Proton Exchange Membrane Electrolysers
Authors: Tang Jialin , Liu Xinyan , Xiong Xiaoxia , Zeng Qisheng , Ji Yuan , Liu Chunxiao , Li Jiawei , Zeng Hongliang , Dai Yizhou , Zhang Xinyan , Li Chengbo , Peng Hongjie , Jiang Qiu , Zheng Tingting , Pao Chih‐Wen , Xia Chuan 
Published: August 2024

AbstractProton exchange membrane water electrolysers promise to usher in a new era of clean energy, but they remain a formidable obstacle in designing active and durable electrocatalysts for the acidic oxygen evolution reaction (OER). In this study, a protonated iridium oxide embedded with single‐atom dispersed ruthenium atoms (H3.8Ir1−xRuxO4) that demonstrates exceptional activity and stability in acidic water oxidation is introduced. The single Ru dopants favorably induce localized oxygen vacancies in the Ir─O lattice, synergistically strengthening the adsorption of OOH* intermediates and enhancing the intrinsic OER activity. In addition, the preferential oxidation of Ru and the electronegativity of the oxygen vacancies significantly stabilize the Ir─O active sites, improving the OER stability. Consequently, the H3.8Ir1─xRuxO4 catalyst shows an overpotential of 255 mV at 10 mA cm−2 and displays exceptional catalytic endurance in acidic electrolytes, surpassing 1100 h, representing a remarkable one‐order‐of‐magnitude increase in stability compared to that of pristine H3.8IrO4. A proton exchange membrane electrolyser utilizing the H3.8Ir1−xRuxO4 catalyst as an anode exhibits stable performance for more than 1280 h under a high current density of 2 A cm−2.
Modulating the Electronic Structure of Cobalt‐Vanadium Bimetal Catalysts for High‐Stable Anion Exchange Membrane Water Electrolyzer
Authors: Liang Zhijian , Shen Di , Wei Yao , Sun Fanfei , Xie Ying , Wang Lei , Fu Honggang 
Published: August 2024

AbstractModulating the electronic structure of catalysts to effectively couple the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is essential for developing high‐efficiency anion exchange membrane water electrolyzer (AEMWE). Herein, a coral‐like nanoarray composed of nanosheets through the synergistic layering effect of cobalt and the 1D guiding of vanadium is synthesized, which promotes extensive contact between the active sites and electrolyte. The HER and OER activities can be enhanced by modulating the electronic structure through nitridation and phosphorization, respectively, enhancing the strength of metal‐H bond to optimize hydrogen adsorption and facilitating the proton transfer to improve the transformation of oxygen‐containing intermediates. Resultantly, the AEMWE achieves a current density of 500 mA cm–2 at 1.76 V for 1000 h in 1.0 M KOH at 70 °C. The energy consumption is 4.21 kWh Nm–3 with the producing hydrogen cost of $0.93 per kg H2. Operando synchrotron radiation and Bode phase angle analyses reveal that during the high‐energy consumed OER, the dissolution of vanadium species transforms distorted Co−O octahedral into regular octahedral structures, accompanied by a shortening of the Co−Co bond length. This structural evolution facilitates the formation of oxygen intermediates, thus accelerating the reaction kinetics.
Polymeric Nanocarriers Autonomously Cross the Plant Cell Wall and Enable Protein Delivery for Stress Sensing
Authors: Zhang Yilin , Cao Yunteng , Jiang Wenzhi , Ma Qingquan , Shin Jinwoo , Sun Hui , Cui Jianqiao , Chen Yongsheng , Giraldo Juan Pablo , Strano Michael S. , Lowry Gregory V. , Sheen Jen , Marelli Benedetto 
Published: August 2024

AbstractDelivery of proteins in plant cells can facilitate the design of desired functions by modulation of biological processes and plant traits but is currently limited by narrow host range, tissue damage, and poor scalability. Physical barriers in plants, including cell walls and membranes, limit protein delivery to desired plant tissues. Herein, a cationic high aspect ratio polymeric nanocarriers (PNCs) platform is developed to enable efficient protein delivery to plants. The cationic nature of PNCs binds proteins through electrostatic. The ability to precisely design PNCs’ size and aspect ratio allowed us to find a cutoff of ≈14 nm in the cell wall, below which cationic PNCs can autonomously overcome the barrier and carry their cargo into plant cells. To exploit these findings, a reduction‐oxidation sensitive green fluorescent protein (roGFP) is deployed as a stress sensor protein cargo in a model plant Nicotiana benthamiana and common crop plants, including tomato and maize. In vivo imaging of PNC‐roGFP enabled optical monitoring of plant response to wounding, biotic, and heat stressors. These results show that PNCs can be precisely designed below the size exclusion limit of cell walls to overcome current limitations in protein delivery to plants and facilitate species‐independent plant engineering.
Probing Charge Transport and Microstructural Attributes in Solvent‐ versus Water‐Based Electrodes with a Spotlight on Li–S Battery Cathode
Authors: Yari Saeed , Bird Liam , Rahimisheikh Sepideh , Reis Albin Conde , Mohammad Mahsa , Hadermann Joke , Robinson James , Shearing Paul R. , Safari Mohammadhosein 
Published: August 2024

AbstractIn the quest for environmentally benign battery technologies, this study examines the microstructural and transport properties of water‐processed electrodes and compares them to conventionally formulated electrodes using the toxic solvent, N‐Methyl‐2‐pyrrolidone (NMP). Special focus is placed on sulfur electrodes utilized in lithium‐sulfur batteries for their sustainability and compatibility with diverse binder/solvent systems. The characterization of the electrodes by X‐ray micro‐computed tomography reveals that in polyvinylidene fluoride (PVDF)/NMP, sulfur particles tend to remain in large clusters but break down into finer particles in carboxymethyl cellulose‐styrene butadiene rubber (CMC‐SBR)/water and lithium polyacrylate (LiPAA)/water dispersions. The findings reveal that in the water‐based electrodes, the binder properties dictate the spatial arrangement of carbon particles, resulting in either thick aggregates with short‐range connectivity or thin films with long‐range connectivity among sulfur particles. Additionally, cracking is found to be particularly prominent in thicker water‐based electrodes, propagating especially in regions with larger particle agglomerates and often extending to cause local delamination of the electrodes. These microstructural details are shown to significantly impact the tortuosity and contact resistance of the sulfur electrodes and thereby affecting the cycling performance of the Li‐S battery cells.
Ultrahigh Energy Density and Ultrafast Response in Symmetric Microsupercapacitors with 3D Bicontinuous Pseudocapacitance
Authors: Kim Min Ji , Kim Minjeong , Sohn Won Bae , Kang JoonHyun , Kim Woong , Kang Jin Gu 
Published: August 2024

AbstractAchieving a high storage capability while maintaining good rate performance using symmetric microsupercapacitors (MSCs) remains challenging. Herein, a 3D symmetric MSC based on interdigitated 3D bicontinuous pseudocapacitive electrodes is proposed to simultaneously attain ultrahigh energy density and ultrafast response. The 3D electrodes comprise electrolytically active MnO2 layers conformally coated onto a 3D periodic porous Ni current collector. In this architecture, the low conductivity of MnO2 can be compensated by efficient charge transport and facile charge transfer without compromising its high capacitance. The 3D MSC with a 1‐V window exhibits an ultrahigh volumetric energy density of 15.8 mWh cm−3 with a high power density of 4.95 W cm−3, outperforming all previously reported MnO2‐based symmetric MSCs. Benefitting from its ultrafast response, the 3D MSC exhibits superiority in terms of the phase angle (−66°), areal capacitance (1400 µF cm−2), and time constant (0.6 ms) at an alternating‐current (AC) frequency of 120 Hz. By using the 3D MSC as a line‐filtering capacitor in a real circuit, the AC signal is effectively smoothed with small residual ripples (≈1.35 mV). Additionally, the device achieves excellent performance in an all‐solid‐state form.
Revealing Phase Transitions in Poly(Ethylene Oxide)‐Based Electrolyte for Room‐Temperature Solid‐State Batteries
Authors: Ding Ning , Chien Sheau Wei , Tam Teck Lip Dexter , Li Xiaodong , Wu Gang , Lee Won Jun , Chiam Sing Yang , Meng Ying Shirley , Fam Derrick Wen Hui 
Published: August 2024

AbstractSolid‐state electrolytes (SSEs) offer enhanced safety, extended cycle life, and increased energy density when replacing flammable liquid electrolytes in lithium‐ion batteries. Poly(ethylene oxide) (PEO)‐based SSE is the only candidate that has been commercially implemented in electric vehicles. However, the equipped battery needs to operate at temperatures above 50 °C, and its phase transitions at room temperature are still unclear. Herein, the solidification of the PEO‐lithium bis(trifluoromethanesulfonyl)imide (PEOn‐LiTFSI) system is revisited. Contrary to the prevailing view of forming PEO(6)‐LiTFSI spherulites, the presence of crystalline PEO(8)‐LiTFSI complexes is quantitatively confirmed. The nucleation and growth processes of crystalline PEO and PEO(8)‐LiTFSI spherulites are also visually elucidated, and phase transitions with the impedance change are correlated. In addition, it is demonstrated that the crystalline PEO shell surrounding the PEO(8)‐LiTFSI spherulites hinders the kinetics of crystal growth, thereby enabling the highest ionic conductivity at n = 10. Importantly, it is pointed out that instead of the poor ionic conductivity of the electrolyte layer, the heterogeneous nucleation of PEO(8)‐LiTFSI within the electrodes is the limiting factor in constructing room‐temperature all‐solid‐state batteries.
Double somatic mosaicism in Marfan syndrome
Authors: Carrera Ignacio Arroyo , Amor‐Salamanca Almudena , Isidro Elena Márquez , Pérez‐Barbeito Marlene , Sacristán Ana Raquel Barrio , Ochoa Juan Pablo 
Published: August 2024

AbstractMarfan syndrome (MFS) is a hereditary systemic connective tissue disorder with great clinical variability. It is caused by heterozygous pathogenic variants in the FBN1 gene. Cardinal manifestations involve the cardiovascular, ocular, and skeletal systems. Clinical diagnosis is based on the revised Ghent nosology. We present the case of a child with a Marfan systemic score of 9 whose genetic study revealed two pathogenic mosaic frameshift variants in the FBN1 gene. Mosaicism is very rare in patients diagnosed with MFS, and this is the first description of a patient with two pathogenic mosaic variants in the FBN1 gene. Both variants are present in cells derived from ectodermal (buccal swab) and mesodermal (leukocyte) tissues, suggesting a mutation prior to gastrulation. We propose a defective repair of the de novo variant in the complementary strand as the mechanism that led this individual to be a carrier of two different populations of mutant cells carrying adjacent variants.
CNOT1 p.Arg535Cys variant in holoprosencephaly with late onset diabetes mellitus
Authors: de Queiroz Júnior Amaro Freire , Sanseverino Maria Teresa Vieira , Collares Marcus Vinicius Martins , Fornari Adriana , do Virmond Luiza Amaral , Filho João Bosco Oliveira , Artigalás Osvaldo , Félix Têmis Maria 
Published: August 2024

AbstractHoloprosencephaly (HPE) results from a lack of cleavage of the prosencephalon. It has a complex etiology, resulting from chromosome abnormalities or single gene variants in the Sonic hedgehog signaling pathway. A single variant, p.Arg535Cys in CNOT1, has been described in HPE in association with pancreatic agenesis and neonatal diabetes. Here, we report on a case of HPE and p.Arg535Cys in CNOT1 without pancreatic agenesis where the patient presented with diabetes mellitus in adolescence. This case reinforces the role of CNOT1 in pancreatic development. We suggest that individuals with p.Arg535Cys in CNOT1 with no pancreas abnormalities observed at birth should be screened for diabetes during follow‐up.
Longitudinal echocardiography in pediatric patients with hypermobile Ehlers‐Danlos syndrome
Authors: Lahey Hannah , Shin Haewon , Myers Katherine , McBride Kim L. 
Published: August 2024

AbstractVascular Ehlers‐Danlos, Marfan and Loeys‐Dietz syndromes have increased risk of aortic dilation and dissection. Previous early studies showed hypermobile Ehlers‐Danlos syndrome (hEDS) may also have increased risk, with echocardiography screening recommended; subsequent studies have not confirmed the risk or recommended echocardiography. This pediatric‐based study assessed aortic dilation prevalence in those with hEDS by serial echocardiographic examinations and assessed family history for aortic dissections. We retrospectively identified individuals with hEDS who had echocardiography studies from the electronic medical records at one pediatric center. Aortic root Z‐scores >2.0 were found in 15/225 subjects (average age 12.9 years) on initial echocardiograms, with no Z‐score >3.0. Subsequent studies (n = 68) found statistically significant decline in aortic root Z‐scores. Repeat echocardiography in those with initial aortic root Z‐score >2.0 (n = 10) demonstrated a decline in Z score <2.0 in seven. On final examination, 9/225 (4.0%) had a Z‐score >2.0, not statistically different from the general population. No aortic dissection occurred in first‐ or second‐degree relatives. In conclusion, aortic root dilation rate in hEDS is likely not different from the general population. We propose that in the absence of other cardiac findings or suspicion for another disorder, echocardiography is not required in hEDS.