bluuebunny/crossref_metadata_2025_split huggingface dataset:
FhaA plays a key role in mycobacterial polar elongation and asymmetric growth
Authors: Rossello Jessica , Rivera Bernardina , Fialho Maximiliano Anzibar , Augusto Ingrid , Gil Magdalena , Forrellad Marina Andrea , Bigi Fabiana , Taño Azalia Rodríguez , Urdániz Estefanía , Piuri Mariana , Miranda Kildare , Wehenkel Anne Marie , Alzari Pedro M , Malacrida Leonel , Durán Rosario 
Published: August 2024

AbstractMycobacteria, including pathogens likeMycobacterium tuberculosis, exhibit unique growth patterns and cell envelope structures that challenge our understanding of bacterial physiology. This study sheds light on FhaA, a conserved protein inMycobacteriales, revealing its pivotal role in coordinating cell envelope biogenesis and asymmetric growth.The elucidation of the FhaA interactome in living mycobacterial cells reveals its participation in the protein network orchestrating cell envelope biogenesis and cell elongation/division. By manipulating FhaA levels, we uncovered its influence on cell morphology, cell envelope organization, and the localization of peptidoglycan biosynthesis machinery. Notably,fhaAdeletion disrupted the characteristic asymmetric growth of mycobacteria, highlighting its importance in maintaining this distinctive feature.Our findings position FhaA as a key regulator in a complex protein network, orchestrating the asymmetric distribution and activity of cell envelope biosynthetic machinery. This work not only advances our understanding of mycobacterial growth mechanisms but also identifies FhaA as a potential target for future studies on cell envelope biogenesis and bacterial growth regulation. These insights into the fundamental biology of mycobacteria may pave the way for novel approaches to combat mycobacterial infections addressing the ongoing challenge of diseases like tuberculosis in global health.
A non-catalytic function of a disintegrin and metalloprotease 10 determines hepatic progenitor cell fate
Authors: Wöhner Birte , Müller Miryam , Pearen Michael , Köhn-Gaone Julia , Gorki Luise , Philippsen Rebecca , Gogoi-Tiwari Jully , John Clara , Scheja Ludger , Krause Freia , Halwachs Birgit , Barikbin Roja , Schwinge Dorothee , Rose-John Stefan , Saftig Paul , Schramm Christoph , Olynyk John K. , Heeren Jörg , Tirnitz-Parker Janina EE , Ramm Grant A , Schmidt-Arras Dirk 
Published: August 2024

AbstractDuring chronic liver disease, hepatocytes may undergo proliferative arrest, leading to the activation, expansion and differentiation of hepatic progenitor cells (HPCs). Here we observe that expression of A Disintegrin And Metalloprotease (ADAM) 10 is increased in human and murine chronic liver disease correlating with HPC expansion. We report that proteolytic processing of ADAM10 by ADAM9 and generation of an ADAM10 intracellular domain that translocates to the nucleus, rather than ADAM10 enzymatic activity is essential for the regulation of HPC gene expression and differentiation. Genetic loss of ADAM10in vitroandin vivoenhances stemness gene expression, increases the accumulation of undifferentiated HPCs and promotes the formation of liver fibrosis. Taken together, we demonstrate that a non-catalytic function of ADAM10 is an essential regulator of HPC fate and HPC-driven regeneration. Our data ascribe a non-proteolytic function to ADAM proteases which may be a general concept in adult tissue stem cells.
The role of perceived proximity and employee voice in teleworkers’ well-being
Authors: Labrado-Antolín Maribel , Rodríguez-Ruiz Óscar , Fernández-Menéndez José 
Published: August 2024

PurposeThis paper studies the impact that perceived proximity and employee voice have on the affective well-being of employees working from home (WFH). Drawing on Wilson et al.'s (2008) model of perceived proximity in virtual work, we believe that effectiveness in the use of the enterprise social network (ESN), communication and workmate identification increase the perceived proximity of teleworkers. We also propose that employee voice and perceived proximity have in turn positive implications in terms of well-being.Design/methodology/approachThe study analyzes a dataset of 542 professionals with experience in home-based telework. Structural equation modeling (SEM) has been used to test the proposed hypotheses.FindingsResults show that perceived proximity is significant and positively associated with affective well-being. Conversely, the expression of direct voice using electronic channels has a negative influence on the well-being of home-based teleworkers.Originality/valueThis study reveals the need to re-think the challenges of telework after the forced experiment of WFH provoked by the COVID-19 pandemics. Building on the “far-but-close” paradox, it emphasizes the role of workmate identification and communication and the perceived effectiveness of the ESN as sources of perceived proximity. At the same time, the paper adds to telework research by explaining how the expression of direct voice through electronic channels and indirect voice can have consequences in terms of well-being.
A morphology-Euclidean-linear recognition method for rebar point clouds of highway tunnel linings during the construction phase
Authors: Zhou Lizhi , Wang Chuan , Niu Pei , Zhang Hanming , Zhang Ning , Xie Quanyi , Wang Jianhong , Zhang Xiao , Liu Jian 
Published: August 2024

PurposeLaser point clouds are a 3D reconstruction method with wide range, high accuracy and strong adaptability. Therefore, the purpose is to discover a construction point cloud extraction method that can obtain complete information about the construction of rebar, facilitating construction quality inspection and tunnel data archiving, to reduce the cost and complexity of construction management.Design/methodology/approachFirstly, this paper analyzes the point cloud data of the tunnel during the construction phase, extracts the main features of the rebar data and proposes an M-E-L recognition method. Secondly, based on the actual conditions of the tunnel and the specifications of Chinese tunnel engineering, a rebar model experiment is designed to obtain experimental data. Finally, the feasibility and accuracy of the M-E-L recognition method are analyzed and tested based on the experimental data from the model.FindingsBased on tunnel morphology characteristics, data preprocessing, Euclidean clustering and PCA shape extraction methods, a M-E-L identification algorithm is proposed for identifying secondary lining rebars in highway tunnel construction stages. The algorithm achieves 100% extraction of the first-layer rebars, allowing for the three-dimensional visualization of the on-site rebar situation. Subsequently, through data processing, rebar dimensions and spacings can be obtained. For the second-layer rebars, 55% extraction is achieved, providing information on the rebar skeleton and partial rebar details at the construction site. These extracted data can be further processed to verify compliance with construction requirements.Originality/valueThis paper introduces a laser point cloud method for double-layer rebar identification in tunnels. Current methods rely heavily on manual detection, lacking objectivity. Objective approaches for automatic rebar identification include image-based and LiDAR-based methods. Image-based methods are constrained by tunnel lighting conditions, while LiDAR focuses on straight rebar skeletons. Our research proposes a 3D point cloud recognition algorithm for tunnel lining rebar. This method can extract double-layer rebars and obtain construction rebar dimensions, enhancing management efficiency.
The relationship between the cost of living and food security in developing countries. Evidence from Ghana
Authors: Sogah Ernest , Mawutor John Kwaku Mensah , Gborse Freeman Christian 
Published: August 2024

PurposeThe aim of the quantity study is to investigate the cost of living and food security nexus in Ghana. Time series secondary quarterly data from 2012Q1 to 2018Q4 were examined.Design/methodology/approachThe autoregressive distributed lag (ARDL) to cointegration bound test was employed for the econometrics analysis. Time series secondary quarterly data from 2012Q1 to 2018Q4 were examined. Food security data based on the Global Food Security Index score were employed.FindingsThe result revealed that the variables are cointegrated in the long run. The study also revealed that the cost of living worsens food security in Ghana both in the short run and the long run. This could imply that people may not have enough money to afford adequate and nutritious food, which can lead to food insecurity. As the cost of living increases, people may have to spend more of their income on basic necessities such as housing, healthcare and transportation, leaving less money for food. This can result in people choosing cheaper and less nutritious options, or even skipping meals, which can have negative impacts on their health and well-being.Practical implicationsFor policy implications, it is recommended that effort should be made by the Ministry of Finance Ghana, financial analysts and other economic agents to stabilize prices of goods and services in the country.Originality/valueThe study is among the few to have investigated the nexus between the cost of living and food security in non-Western economy using the secondary data.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-04-2023-0309
Gaining acceptance for digital servitization: the role of legitimacy in the development of a smart service in established manufacturing ecosystems
Authors: Kristiansen Marius , Aas Tor Helge 
Published: August 2024

Purpose
Digital servitization research has focused on how manufacturing firms use digital technologies to change business models and offer smart services; less attention has been devoted to the degree to which external actors in the existing ecosystem accept these smart services. Therefore, the authors pose the following research question: How does a manufacturing firm introduce and gain acceptance of new smart services within an established ecosystem?

Design/methodology/approach
Building on servitization, ecosystem and legitimacy theories, this paper addresses the research question through an in-depth case study of a world-leading original equipment manufacturer that is currently developing and introducing new smart services in its existing ecosystem.

Findings
The findings suggest that external actors emphasize different types of legitimacy in deciding whether to accept a new smart service. The findings also show that the type of legitimacy required to gain acceptance changes throughout the development of the smart service, from the definition of the value proposition to the design and delivery of the service.

Practical implications
This study can assist smart service providers in identifying which type of legitimacy is important for each ecosystem actor and strengthening these types of legitimacy to gain acceptance from the ecosystem.

Originality/value
This study develops a framework to help describe the thresholds for acceptance of a smart service through the development phases, as well as to indicate the types of legitimacy that smart service providers must relate to when seeking to gain acceptance for their new offering.
Teaching ethics and ethical leadership with the Harvard Everest simulation
Authors: Lvina Elena 
Published: August 2024

PurposeThis is a step-by-step guide for teaching Ethics and Ethical Leadership utilizing the Harvard Everest Leadership and Teams Simulation, V.3. The suggested approach is focused on facilitating a discussion and coaching students to recognize and solve problems by applying moral theory explicitly and deliberately. Applying this approach can also help them develop a habit of analyzing one’s own and others' behavior using ethical lenses and principles of authentic leadership. It offers practical debrief steps and specific discussion questions that can be used as a standalone resource or alongside the Harvard teaching note accompanying the simulation.Design/methodology/approachThis innovative approach enables teaching and coaching students on the ethical aspects of their leadership and decision-making based on this hands-on experience with the Harvard Everest Leadership and Teams Simulation. This approach enriches the original HBR teaching suggestions by enabling students to recognize moral dilemmas, confront typical rationalizations and practice ethical actions and decision-making in real time.FindingsIn-class discussion and student reflection assignments provide evidence of the method's effectiveness in translating values into impactful insights and enhanced likelihood of ethical behaviors in real-life scenarios. Students’ end-of-class feedback and course evaluations often cite the benefits of using the Everest simulation as a backdrop for raising self-awareness and practicing ethical decision-making.Practical implicationsThe approach discussed in the paper can serve as a flexible framework for analyzing and debriefing the HBR Everest simulation and other simulations, “survival scenario” exercises and activities designed to teach and facilitate practicing ethical leadership, authentic leadership and ethical decision making. It is adaptable and can be effectively applied across various disciplines centered around ethical leadership, teamwork, communication and decision-making in higher education and business.Originality/valueHarvard Everest Leadership and Teams Simulation is among the most popular ones in business education and is used by teachers worldwide (Roberto & Edmondson, 2017). While a comprehensive teaching note on communication and group dynamics is available through Harvard Business Publishing, it still needs to address the ethical issues students face during the simulation. This paper provides a roadmap for instructors who want to improve the student experience with ethical decision-making and ethical leadership.
Does too much or too little task conflict hurt service performance? A multilevel curvilinear model
Authors: Yang Mingjun , Luu Tuan , Wang Dan 
Published: August 2024

Purpose The quality of service determines whether service firms can satisfy customers and achieve business quality and sustainability. As contemporary service firms are dependent on both team and employee to serve customers, it is important to investigate how to simultaneously facilitate team service performance (TSP) and employee service performance (ESP). Our aim is to build a multilevel model of the curvilinear effect of task conflict (TC) on TSP and ESP, as well as the moderating effects underlying the above curvilinear relationships.Design/methodology/approach Two-sourced data were obtained from 47 team leaders and 326 employees in Chinese hotels. Multilevel structural equation modeling was utilized for validating the model.Findings The results revealed that TC exerted a curvilinear effect on both TSP and ESP. Ethical climate (EC) and internal knowledge transfer (IKT) served as moderators strengthening the curvilinear nexus between TC and ESP.Originality/value We contribute to the conflict-performance stream in management literature by unmasking the curvilinear effects of TC on both TSP and ESP, and the moderation mechanisms underlying such curvilinear effects.
Chronic illness as cultural disruption: The impact of chronic illness on religious and cultural practice
Authors: Cluley Victoria , Trivedi Adya , Burton James O. 
Published: August 2024

AbstractThe relationship between religion and health tends to be framed positively. Religion has been found to act as a coping mechanism and source of support in times of ill health. In this paper, we focus on the disruptive effect of chronic illness on religious practice and cultural engagement. Drawing on interviews with ethnic minority adults with end‐stage kidney disease, who also identify as religious, we introduce the concept ‘cultural disruption’. While religious practice and belief was found to provide strength and comfort we also found that chronic illness had a disruptive impact on religious and cultural practice that participants attempted to manage. To highlight the potential disruptive effect of chronic illness on religious faith and cultural engagement we identify three elements of cultural disruption—disruption to religious practice, disruption to sense of self and identity and disruption to wellbeing. We conclude by suggesting that understanding and accounting for the potential of cultural disruption when diagnosing, treating and supporting people with chronic illness offers an alternative entry point to the life‐worlds of patients who identify as religious and the things that are important to them.
Parents' and healthcare providers' perceptions, experiences, knowledge of, and attitudes toward kangaroo care of preterm babies in hospital settings: Mixed‐methods systematic review
Authors: Almutairi Amal , Gavine Anna , McFadden Alison 
Published: August 2024

AbstractBackgroundKangaroo care is an effective intervention to increase survival and improve the health and development of preterm infants. Despite this, implementation of kangaroo care globally remains low. The objectives of this review were to: (a) synthesize evidence on parents' and healthcare practitioners' perceptions, experiences, knowledge of, and attitudes toward kangaroo care of preterm babies in hospital settings; and (b) establish parents' satisfaction with kangaroo care.MethodsStudies of any design were included if they focused on parents' or healthcare practitioners' perceptions, experiences, knowledge of, and attitudes to kangaroo care of preterm babies, or reported parents' satisfaction, and were conducted in hospital settings. The search of seven electronic databases, African Journals Online, World Health Organization regional databases, and a gray literature search was conducted in April/May 2020, and updated in January 2024. Study selection was undertaken by two independent reviewers. Quality assessment using the Mixed Method Appraisal Tool and data extraction were completed by one reviewer with a 10% check by a second reviewer. Data were synthesized narratively using a parallel results convergent integrated design.ResultsThirty‐seven studies, 19 quantitative, 16 qualitative, and 2 mixed methods, were included. The findings suggested that while healthcare practitioners generally demonstrated knowledge about kangaroo care, there was a notable minority with insufficient understanding among those who received training. Parents' knowledge, particularly among fathers, was limited. Both healthcare practitioners and parents appeared to have positive attitudes to kangaroo care. Little is known about parental satisfaction with kangaroo care.ConclusionsMost healthcare practitioners were knowledgeable about kangaroo care, but parents had limited knowledge. This review findings suggest a need to enhance parental knowledge of kangaroo care before neonatal unit admission, and training is needed for HCPs to implement kangaroo care consistently.
Labor outcomes in caseload midwifery compared with standard midwifery care: A cohort study
Authors: Hjorth Sarah , Brülle Anne‐Line , Kristensen Helle , Frederiksen Anette , Nohr Ellen Aagard 
Published: August 2024

AbstractBackgroundResearch has shown caseload midwifery to increase the chance of vaginal birth, but this may not be the case in settings with high vaginal birth rates in standard care. This study investigated the association between caseload midwifery and birth mode, labor interventions, and maternal and neonatal outcomes at a large obstetric unit in Denmark.MethodsCohort study including medical records on live, singleton births fr om June 2018 until February 2022. Exposure was caseload midwifery care compared with standard midwifery care. The primary outcome was birth mode, and secondary outcomes were other outcomes of labor. Adjusted risk ratios (aRR) with 95% confidence intervals (CI) were estimated by log‐binomial regression.ResultsAmong 16,110 pregnancies, 3162 pregnancies (19.6%) received caseload midwifery care. Caseload midwifery was associated with fewer planned cesareans (aRR 0.63 [95% CI 0.54–0.74]) and emergency cesareans (aRR 0.86 [95% CI 0.75–0.95]). No differences in labor induction, use of epidural analgesia, oxytocin augmentation, or anal sphincter tears were observed. Caseload midwifery performed more amniotomies (aRR 1.14 [95% CI 1.02–1.27]) and tended to perform more episiotomies (aRR 1.19 [95% CI 0.96–1.48]). Postpartum hemorrhage (aRR 0.90 [95% CI 0.82–0.99]) and low Apgar score were less likely (aRR 0.54 [95% CI 0.37–0.77]), and early discharge more likely (aRR 1.22 [95% CI 1.17–1.28]) in caseload midwifery.ConclusionIn caseload midwifery care, a higher vaginal birth rate was observed with no increase in adverse outcomes, mainly due to a lower likelihood of planned cesarean. Also, fewer children were born with low Apgar scores.
A technological construction of society: Comparing GPT‐4 and human respondents for occupational evaluation in the UK
Authors: Gmyrek Paweł , Lutz Christoph , Newlands Gemma 
Published: August 2024

AbstractDespite initial research about the biases and perceptions of large language models (LLMs), we lack evidence on how LLMs evaluate occupations, especially in comparison to human evaluators. In this paper, we present a systematic comparison of occupational evaluations by GPT‐4 with those from an in‐depth, high‐quality and recent human respondents survey in the UK. Covering the full ISCO‐08 occupational landscape, with 580 occupations and two distinct metrics (prestige and social value), our findings indicate that GPT‐4 and human scores are highly correlated across all ISCO‐08 major groups. At the same time, GPT‐4 substantially under‐ or overestimates the occupational prestige and social value of many occupations, particularly for emerging digital and stigmatized or illicit occupations. Our analyses show both the potential and risk of using LLM‐generated data for sociological and occupational research. We also discuss the policy implications of our findings for the integration of LLM tools into the world of work.
Fusobacterium nucleatum, immune responses, and metastatic organ diversity in colorectal cancer liver metastasis
Authors: Shigematsu Yasuyuki , Saito Rumiko , Amori Gulanbar , Kanda Hiroaki , Takahashi Yu , Takeuchi Kengo , Takahashi Shunji , Inamura Kentaro 
Published: August 2024

AbstractThe presence of Fusobacterium nucleatum is associated with an immunosuppressive tumor immune microenvironment (TIM) in primary colorectal cancer (CRC), contributing to tumor progression. Its persistence in CRC liver metastasis tissues raises questions about its role in modulating local and systemic immune responses and influencing recurrence patterns. This retrospective cohort study of 218 patients with CRC liver metastasis investigated the association of F. nucleatum in CRC liver metastasis tissues with systemic inflammation, TIM alterations, and the number of metastatic organs involved in recurrence. Two‐step polymerase chain reaction (PCR), including digital PCR, detected F. nucleatum in 42% (92/218) of fresh‐frozen specimens of CRC liver metastases. Compared with the F. nucleatum‐none group, the F. nucleatum‐high group showed higher C‐reactive protein levels (0.82 vs. 0.22 mg/dL; Ptrend = 0.02), lower numbers of CD8+ cells (33.2 vs. 65.3 cells/mm2; Ptrend = 0.04) and FOXP3+ cells (11.3 vs. 21.7 cells/mm2; Ptrend = 0.01) in the TIM, and a greater number of metastatic organs involved in recurrence (1.6 vs. 1.1; p < 0.001). The presence of F. nucleatum in CRC liver metastasis tissues was associated with increased systemic inflammation, TIM alterations, and a greater number of metastatic organs involved in recurrence. These findings suggest a potential contribution of F. nucleatum to the metastatic propensity of CRC cells and could inform future research to enhance understanding of the interaction between tumor, host, and microbes in the metastatic process.