bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПЕРСПЕКТИВИ ВИРОБНИЦТВА М’ЯКИХ БІЛИХ СИРІВ В УКРАЇНІ
Authors: Чагаровський О. П. , Дідух Є. Г. , Кондрацький С. В. 
Published: August 2024

У статті розглянуто експорт та імпорт сирів в Україну протягом останніх 4 років. Проведений аналіз свідчить, що найбільшими експортерами сирів до України є Польща (48%); Німеччина (20%); Франція (8%); Нідерланди (7%) та Італія (4%). Із імпортованих сирів відзначено зростання попиту на рідкісні сорти сирів, зокрема, на сир Брі (Brіe) – у 1,5 рази; на сир Камамбер (Camembert) – у 1,5 рази. Кількість імпортованих м’яких білих сирів в Україну складала близько 4,3 тис.тонн у 2020 році, а до 2023 року зменшилася на 24 %. Експорт українських сирів зріс протягом 2023 року на 104%; країна експортує, в основному, тверді сири, які виробляють як провідні крупні сироробні підприємства, так і невеликі крафтові виробники.
Визначено переваги респондентів – молодих споживачів України (переважно у віці 18–35 років) – щодо вживання сирів різних груп. Показано, що 51% споживачів віддають перевагу свіжим сирам, на другому місці за популярністю у респондентів (31%) – м’які білі сири, зокрема, м’які сири Камамбер та Брі. Тому саме ці групи сирів є перспективними до розроблення та впровадження у найближчій перспективі.
Обґрунтовано можливість та доцільність застосування заквасок безпосереднього внесення компанії Chr. Hansen (Данія) FD-DVS CHN-22, FD-DVS CHN-11, FD-DVS CHN-19 та FD-DVS Flora danica у виробництві м’яких білих сирів Камамбер та Брі, оскільки ці закваски містять L. lactis, L. cremoris, L. diacetilactis, а також гетероферментативну культуру Leuconostoc mesentroides, і дозволять виробляти м’які білі сири високої та постійної якості. З огляду на перспективи розроблення м’яких біфідовмісних білих сирів рекомендовано використання культури FD-DVS BB-12-Probio-TecTM, до складу якої входять монокультури Bifidobacterium longum ssp. animalis Bb-12.
У технології сиру м’якого Камамбер доцільно застосувати культуру Penicillium candidum у складі закваски безпосереднього внесення FD PCA-3, оскільки ця культура (за даними виробника) надає сиру грибний, сирний насичений смак, має високу швидкість росту та середній рівень протеолізу та ліполізу; для розроблення технології сиру м’якого Брі – культур Geotrichum candidum у складі закваски безпосереднього внесення SWING GEO CD-1, оскільки ця культура надає сиру пліснявий смак, має високу активність амінопептидази, середній рівень протеолізу та ліполізу, а також забезпечує нейтральний профіль смаку, що дасть можливість здійснювати визрівання сиру Брі.
Як молокосзідальний фермент рекомендовано використання 100%-вого хімозину СНУ-МАХ компанії Chr. Hansen (Данія) у рідкій формі.
The Breeding colonies, population growth and breeding success of the Dalmatian pelican Pelecanus crispus in Greece: a country-wide perspective, 1967-2021
Authors: Catsadorakis Giorgos , Alexandrou Olga , Hatzilacou Dionyssia , Kasvikis Ioannis , Katsikatsou Maria , Konstas Spyros , Malakou Myrsini , Michalakis Dimitrios , Naziridis Theodoros , Nikolaou Haris , Noulas Nikolaos , Portolou Danae , Roussopoulos Yiannis , Vergos Ioannis , Crivelli Alain 
Published: August 2024

Greece holds the third larger breeding population of Dalmatian Pelican in the world. We present data about the establishment and growth, breeding performance and conservation status for all six colonies of the species in Greece for 40 years. Main features of wetlands and colonies are described. We discuss the local, regional and global natural and anthropogenic factors that may have affected colony growth.
After 1982 colony surveys were carried out with various methods, adapted to the particularities of each wetland and availability of resources, and targeted estimating number of nests and number of near-fledged young via direct counting either during on-site visits or from vantage points, and recently, counts on photos taken by drones flown one or more times during breeding.
Number of nests in Lake Mikri Prespa rose from ca. 100 to 1200-1500 and levelled-off. DPs from Prespa started breeding successfully in Kerkini in 2004 after placement of artificial nesting rafts. The Karla Reservoir was colonised in 2011, just two years after it started filling with water. The DP colony on Lake Chimaditis, an important stop over and feeding site, probably initiated around 2016 and continues growing. The two colonies at the western coastline have limited exchanges with those in the eastern part of the country. Amvrakikos increased and levelled off recently as conservation and management measures restricted disturbance, whilst emigrants re-established the old colony at Messolonghi in 2011 which continues to grow. The overall breeding population in Greece grew from ca 100 to over 2000 br pairs showing an annual growth rate of 7.9%. Younger colonies show high annual growth rates clearly attributed to immigration, while older colonies have growth rates less than 10%.
Interacting natural and anthropogenic factors are assumed to have contributed to pelican increase in Greece the last 40 years: better legal protection status, increasingly effective protection, patrolling and conservation measures; public awareness campaigns; provision of artificial nesting structures; increased winter survival due to higher temperatures owed to climate change; less disturbance and persecution due to decline of fisheries; increasing abundance and availability of fish due to eutrophication and climate change; increasing numbers of sympatric great cormorants rendering pelican fishing more efficient; appearance of new wetlands and change of wetlands due to human intervention works.
Examining the Completeness of Industry and Occupation Data Among Patients Newly Diagnosed with Cancer in North Carolina
Authors: Angelon-Gaetz Kim , Ikhile Osaremhen , Gordon Howard R. D. , Pearson Melissa , Rao Chandrika 
Published: August 2024

Background Occupational exposure to toxic substances has been associated with cancer. Including industry and occupation (I/O) in cancer surveillance can help identify potential links between occupational exposures and cancers using data already collected to monitor statewide cancer trends. I/O reporting is required in cancer registries and recently in death records. In this study, we examined the completeness of I/O information in North Carolina cancer and death certificate data. Methods The North Carolina Central Cancer Registry (NC CCR) is the sole repository of North Carolina cancer incidence data. NC CCR (2020–2021) and death certificate data (2020–2022) were analyzed for completeness of I/O. NC CCR incidence records for 1995–2021 diagnoses were linked to North Carolina death files (2020–2022). Results NC CCR data had I/O in 17% to 51% of the cases, depending on cancer type. I/O was included in 41% of 2020 death certificates and increased to a 99.9% inclusion in 2021 and 2022 death certificates. In 2020, 20,018 (18%) of 109,677 total deaths matched with a cancer record during NC CCR data linkage. In 2021, 20,225 (16%) of 119,237 total deaths matched with a cancer record, and in 2022, 20,367 (17%) of 116,406 total deaths matched to a cancer record. Limitations Data presented here only examine the completeness of 10 cancer types that the NC CCR regularly analyzes using the most recent data available (2021). Conclusion Health care providers should routinely record I/O using the standards explained in the training for providers on I/O data collection, provided by the North Carolina Department of Health and Human Services, and should increase their frequency of reporting I/O to NC CCR. Death certificate data may provide I/O data for individuals whose information is missing from cancer registry data.
El giro humanitario en la búsqueda de los desaparecidos en América Latina: El caso del Perú
Authors: Rivas Belloso Jairo 
Published: August 2024

En los últimos cincuenta años, un número importante de países latinoamericanos ha enfrentado periodos en los que se produjeron violaciones masivas a los derechos humanos de sus respectivas poblaciones, sea en regímenes dictatoriales, durante conflictos armados internos o en el combate contra el crimen organizado (México). Una de las consecuencias trágicas derivadas de estos contextos es la práctica de desaparición masiva de personas, principalmente por parte de agentes del Estado, pero también por el accionar de actores armados no estatales. Las denuncias planteadas por los familiares de las personas desaparecidas y los organismos de derechos humanos han tenido el efecto de generar obligaciones para los Estados relacionadas con la determinación del paradero de estas víctimas. En los últimos años, esta responsabilidad ha devenido en la creación de entidades gubernamentales especializadas en la búsqueda de los desaparecidos. Bajo el influjo del humanitarismo, estas entidades no pretenden probar el delito ni identificar a los responsables, sino más bien entregar respuestas a los familiares que, por largo tiempo, desconocen el destino final de sus seres queridos. Este artículo, luego de describir la tarea pendiente en materia de búsqueda de las personas desaparecidas, describe el reciente giro humanitario que ha cobrado esta tarea en América Latina y establece un balance inicial respecto a sus posibilidades y limitaciones cuya principal referencia es la experiencia peruana.
Microcontroller-Based Teaching Tool Training to Support Global Warming Physics Learning on MAN 2 Ciracas East Jakarta
Authors: Mangasi Alion Marpaung  , Suhendar Haris 
Published: August 2024

Dalam kegiatan pengabdian masyarakat ini akan dilakukan pengembangan alat peraga pembelajaran yang membantu para siswa di MAN 2 Ciracas dalam memperlajari materi yang berkaitan dengan efek rumah kaca. Efek rumah kaca adalah proses meningkatnya suhu Bumi akibat dari meningkatnya konsentrasi gas karbon dioksida (CO2) di atmosfer sehingga sebagian panas akan di serap oleh gas CO2 sehingga membuat suhu menjadi lebih panas. Meningkatnya konsentrasi gas CO2 diudara disebabkan oleh aktivitas pembakaran energi fosil yang dilakukan manusia untuk memenuhi berbagai kebutuhan energi di Bumi. Oleh karena itu, pemahaman terkait konsep pemanasan global akibat dari fenomena efek rumah kaca harus dikenalkan sejak dini kepada siswa disekolah sehingga dapat meningkatkan kesadaran siswa untuk peduli kepada lingkungan dan mengetahui dampak negatif yang dapat ditimbulkan jika terjadi ketidak setimbangan di alam. Untuk dapat memberikan pemahaman yang baik kepada para siswa maka dibutuhkan bahan ajar yang menarik, dan alat peraga yang dapat menunjukkan bukti peristiwa yang terjadi dilingkungan secara langsung. Oleh karena itu, dalam kegiatan pengabdian masyarakat ini akan dilakukan pengembangan alat peraga pembelajaran yang mengenalkan siswa kepada peristiwa efek rumah kaca. Adapun alat yang digunakan terhubung dengan sensor gas dan sensor suhu yang berfungsi melakukan monitoring kondisi atmosfer dalam wadah yang terkondisikan dengan gas CO2 dengan konsentrasi tertentu. Kemudian wadah eksperimen diberikan sinar dari lampu yang berfungsi seakan – akan sebagai simulasi sinar matahari. Dengan kondisi di sinari maka sebagian panas yang dipancarkan lampu akan diserap oleh gas CO2 diudara sehingga akan meningkatkan suhu udara yang terukur oleh sensor.
Formin-like 1 β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes
Authors: Fernández-Hermira Sara , Sanz-Fernández Irene , Barbeito Pablo , Navarro-Zapata Alfonso , Pérez-Martínez Antonio , Garcia-Gonzalo Francesc R. , Calvo Víctor , Izquierdo Manuel , Ruiz-Navarro Javier 
Published: August 2024

Abstract

T-cell receptor stimulation (TCR) by antigen bound to the major histocompatibility complex (MHC) on an antigen-presenting cell (APC) induces protein kinase C (PKC) activation and the formation of the immune synapse (IS), followed by depletion of filamentous actin (F-actin) at the central region of the IS (cIS) and the polarization of multivesicular bodies (MVB) and the microtubule-organizing center (MTOC) to the IS. These events lead to polarized exosome secretion at the IS. These exosomes are involved in several crucial immune responses such as autocrine activation-induced cell death (AICD) of T lymphocytes and cytotoxicity. We analysed here how formin-like 1 beta (FMNL1beta), an actin cytoskeleton-regulatory protein, regulates MTOC/MVB polarization and exosome secretion at an IS model in a phosphorylation-dependent manner. IS formation was associated with transient recruitment of FMNL1beta to the IS, which was independent of protein kinase C delta (PKCdelta). Simultaneous RNA interference of all FMNL1 isoforms prevented MTOC/MVB polarization and exosome secretion, which were restored by FMNL1betaWT expression. However, expression of the non-phosphorylatable mutant FMNL1βS1086A did not restore neither MTOC/MVB polarization nor exosome secretion to control levels, supporting the crucial role of S1086 phosphorylation in MTOC/MVB polarization and exosome secretion. In contrast, the phosphomimetic mutant, FMNL1βS1086D, restored MTOC/MVB polarization and exosome secretion. Conversely, FMNL1βS1086D mutant did not recover the deficient MTOC/MVB polarization occurring in PKCdelta-interfered clones, indicating that S1086 FMNL1beta phosphorylation alone is not sufficient for MTOC/MVB polarization and exosome secretion. FMNL1 interference inhibited the depletion of F-actin at the cIS, which is necessary for MTOC/MVB polarization. FMNL1betaWT and FMNL1βS1086D, but not FMNL1βS1086A expression, restored F-actin depletion at the cIS. Thus, actin cytoskeleton reorganization at the IS underlies the effects of all these FMNL1beta variants on polarized secretory traffic. FMNL1 was found in the IS made by primary T lymphocytes, both in TCR and chimeric antigen receptor (CAR)-evoked synapses. Taken together, these results point out a crucial role of S1086 phosphorylation in FMNL1beta activation, leading to cortical actin reorganization and subsequent control of MTOC/MVB polarization and exosome secretion.
Study of residual stresses in steel components produced via wire-arc directed energy deposition: finite element analyses and experimental approach
Authors: Liskevych Olga , Ziberov Maksym , de Oliveira Rogerio Lima Mota , de Lima Milton Sergio Fernandes 
Published: August 2024

Abstract

Residual stress evaluation in directed energy deposition processes is of great importance, since its underestimation or lack of control can result in mechanical properties degradation of the produced components and even failure in service, particularly when there is an overlap of tensile stresses originating from repeated thermal cycles. The objective of this study was to perform a systematic analysis of the residual stress generation in wire-arc directed energy deposition produced steel samples. For this purpose, a finite element model was first developed and validated in order to understand the stress distribution in the longitudinal and transverse sections. In addition, test specimens with different numbers of deposited layers were produced by a bidirectional continuous strategy using the cold metal transfer deposition modality, and subjected to experimental residual stress measurements employing an optical hole-drilling method. Dimensional, microstructural, and hardness profile analyses were performed as well. The results obtained in this study demonstrate that the residual stress distribution is not uniform in the wire-arc directed energy deposition produced samples because of the different cooling rates and deposited material volume in the different parts of the studied components. Moreover, different numbers of beam layers, and consequently varying thermal cycles have a significant influence on the type, magnitude, and distribution of the residual stresses, as well as on the dimensional stability and microstructure changes.
In Vitro Comparison of PU, PU-CA, and PU-CA-GO scaffolds to evaluate osteogenic differentiation of mesenchymal stem cells
Authors: Rostami Elnaz , Rostami Solmaz , hosseinzadeh simzar , Maham Hassan Rajabi 
Published: August 2024

Abstract

Background
Nanoscale scaffolds play a significant role in bone tissue engineering due to their appropriate biological activity which could be increased by the presence of nanoparticles such as graphene oxide (GO). This study aimed to develop a scaffold based on polyurethane (PU), cellulose acetate (CA), and GO nanoparticles for bone tissue engineering by electrospinning technique.
Methods
In this study, the scaffolds including PU, PU-CA, and PU-CA-GO, were prepared to assess the differentiation of human adipose-derived mesenchymal stem cells (AD-MSCs) into bone. The scaffolds were characterized via scanning electron microscopy (SEM), FTIR, water contact angle, and tensile test. After cell culture, SEM, DAPI staining, and MTT assay were performed. Then, alizarin red staining (ARS), alkaline phosphatase (ALP) activity, and calcium maps were employed to evaluate the differentiation potential of MSCs.
Results
The results showed that GO nanoparticles were successfully distributed with PU-CA polymer without any agglomerations. The PU-CA-based scaffolds created hydrophilic surfaces that supported cell attachment and proliferation and provided a better milieu for cells. Also, GO increased the strain and Young modulus of the scaffolds and also, better osteogenic differentiation. ALP activity, calcium deposition, and ARS indicated that PU-CA-GO scaffold enables a suitable matrix for the osteogenic differentiation of AD-MSCs.
Conclusion
In general, the porous electrospun PU-CA-GO scaffold with desirable mechanical properties, could increase osteogenic differentiation of AD-MSCs. Hence, this scaffold could be considered as a favorable biodegradable candidate for bone tissue engineering. However, animal evaluations should be considered in future investigations.
Targeting LMO2-induced autocrine FLT3 signalling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia
Authors: Tremblay Cedric , Saw Jesslyn , Yan Feng , Boyle Jacqueline , Amarasinghe Ovini , Abdollahi Shokoufeh , Vo Ngoc Quynh Anh , Shields Benjamin , Mayoh Chelsea , McCalmont Hannah , Evans Kathryn , Steiner Anna , Parsons Kevin , McCormack Matthew , Powell David , Wong Nicholas , Jane Stephen , Lock Richard , Curtis David 
Published: August 2024

Abstract

Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is characterised by aberrant expression of the LMO2-LYL1 stem-cell transcription factor complex, activating mutations of cytokine receptor signalling and poor response to intensive chemotherapy. Previously, studies of the Lmo2 transgenic mouse model of ETP-ALL identified a population of stem-like T-cell progenitors with long-term self-renewal capacity and intrinsic chemoresistance linked to cellular quiescence. Here, analyses of Lmo2 transgenic mice, patient-derived xenografts and single-cell RNA-sequencing data from primary ETP-ALL identified a rare subpopulation of leukemic stem cells expressing high levels of the cytokine receptor FLT3. Despite a highly proliferative state, these FLT3-overexpressing cells had long-term self-renewal capacity and almost complete resistance to chemotherapy. We found that FLT3 and its ligand may be direct targets of the LMO2 stem-cell complex, thereby establishing an autocrine FLT3 signalling loop that could be targeted by the FLT3 inhibitor gilteritinib. Consequently, gilteritinib impaired in vivo growth of ETP-ALL and improved the response to chemotherapy. Furthermore, gilteritinib synergized with the BCL2 inhibitor venetoclax, which may enable ‘chemo-free’ treatment of ETP-ALL. Together, these data provide a cellular and molecular explanation for enhanced cytokine signalling in LMO2-driven ETP-ALL beyond activating mutations and a rationale for clinical trials of FLT3 inhibitors in ETP-ALL.
Future nutraceuticals from minor faunal species: source of novel pharmaceuticals &amp; eco-livelihood
Authors: Tripathi Gireesh , Mukherjee Suchetana , Kumar Arvind , Soni Rajbala , Singh Gajender , Rout Subhalakshmi , Kumar Sanjeet 
Published: August 2024

Abstract

Background
In today’s world, people are facing a food security crisis and unavailability of adequate medicines due to urbanization and consistent increase in the human population. There are several cases of hunger and malnutrition in India, and at the same time, a lot of health problems include microbial infections and poor immunity. To overcome these problems, researchers are searching for unexplored foods with medicinal values that could be nutraceuticals and sources of future pharmaceuticals. Unexplored faunal species are overlooked among the therapeutic foods. Keeping this in mind, the authors conducted field surveys in selected districts of Odisha and Jharkhand states of India during 2022–2023 to document the edible minor faunal species that are consumed by the tribal communities as nutraceuticals.
Results
Through standard procedures and interaction with the local communities, the authors enumerated 31 edible minor faunal species that have both medicinal and food benefits. 26 species of fish, 3 species of insects, and 1 species of each of freshwater crab and freshwater snail make up the 31 minor faunal species. Fish additionally contains fatty acids, which are vital for human health, and the identified minor faunal food are potent in protein and fiber. It has been noted that most of the known edible faunal species are eaten to alleviate fatigue, weakness, heart issues, iron deficiency, and to get vitamins and minerals naturally without any harmful chemicals.
Conclusion
Several overlooked edible faunal species remain unexplored and may prove to be valuable sources of nutraceuticals and pharmaceuticals. The study concludes that 31 species have been identified to have food and therapeutic uses. This finding is also corroborated by the work of other researchers who have added pharmaceutical uses. The study also encourages to carry out cutting-edge research for long-term use, to solve the issues of adequate food and medicine, and to find new potential pharmaceuticals.
Assessment of Faecal Sludge Quality, Heavy Metal Pollution, and Ecological Risk: Implications for Sustainable Agriculture
Authors: Odirile Phillimon , Obuseng Veronica , Moshoeshoe Mohau , Tshenyego Lamong , Mbongwe Bontle 
Published: August 2024

Abstract

Pit latrines represent the predominant form of onsite sanitation in Botswana, posing unique challenges in faecal sludge (FS) management. The key concerns revolve around FS extraction, treatment, and safe disposal. Currently, co-treatment with wastewater is the primary approach, but it strains wastewater treatment plants (WWTPs) and compromises effluent quality. This study comprehensively assesses FS quality from pit latrines and evaluates potential health risks when used in agriculture for soil improvement. Systematic sampling at various depth intervals, approximately 30 cm thick, was conducted, followed by extensive analysis, including heavy metals (copper, iron, lead, cadmium, zinc, manganese, and arsenic). The findings unequivocally demonstrate that FS from VIP latrines poses no significant health risks due to heavy metal content. Specifically, Geo-accumulation Index (Igeo) values for nickel (Ni), chromium (Cr), and arsenic (As) were consistently below zero, indicating negligible risk of environmental contamination. However, copper (Cu) exhibited Igeo values above zero, with a moderate pollution risk but within manageable limits. The high nutrient content, particularly of nitrogen and phosphorus, highlights its agricultural potential, though prudent management is needed to mitigate eutrophication. The study advocates for separate FS treatment, resolving co-treatment operational challenges and enhancing sustainability. Implementing these recommendations promises to address FS management issues, bolster food security, and enhance Botswana's ecological well-being.