bluuebunny/crossref_metadata_2025_split huggingface dataset:
A data-assimilation method for Reynolds-averaged Navier–Stokes-driven mean flow reconstruction
Authors: Foures Dimitry P. G. , Dovetta Nicolas , Sipp Denis , Schmid Peter J. 
Published: November 2014

AbstractWe present a data-assimilation technique based on a variational formulation and a Lagrange multipliers approach to enforce the Navier–Stokes equations. A general operator (referred to as the measure operator) is defined in order to mathematically describe an experimental measure. The presented method is applied to the case of mean flow measurements. Such a flow can be described by the Reynolds-averaged Navier–Stokes (RANS) equations, which can be formulated as the classical Navier–Stokes equations driven by a forcing term involving the Reynolds stresses. The stress term is an unknown of the equations and is thus chosen as the control parameter in our study. The data-assimilation algorithm is derived to minimize the error between a mean flow measurement and the measure performed on a numerical solution of the steady, forced Navier–Stokes equations; the optimal forcing is found when this error is minimal. We demonstrate the developed data-assimilation framework on a test case: the two-dimensional flow around an infinite cylinder at a Reynolds number of $\mathit{Re}=150$. The mean flow is computed by time-averaging instantaneous flow fields from a direct numerical simulation (DNS). We then perform several ‘measures’ on this mean flow and apply the data-assimilation method to reconstruct the full mean flow field. Spatial interpolation, extrapolation, state vector reconstruction and noise filtering are considered independently. The efficacy of the developed identification algorithm is quantified for each of these cases and compared with more traditional methods when possible. We also analyse the identified forcing in terms of unsteadiness characterization, present a way to recover the second-order statistical moments of the fluctuating velocities and finally explore the possibility of pressure reconstruction from velocity measurements.
Investigation of the roughness-induced transition: global stability analyses and direct numerical simulations
Authors: Loiseau Jean-Christophe , Robinet Jean-Christophe , Cherubini Stefania , Leriche Emmanuel 
Published: November 2014

AbstractThe linear global instability and resulting transition to turbulence induced by an isolated cylindrical roughness element of height $h$ and diameter $d$ immersed within an incompressible boundary layer flow along a flat plate is investigated using the joint application of direct numerical simulations and fully three-dimensional global stability analyses. For the range of parameters investigated, base flow computations show that the roughness element induces a wake composed of a central low-speed region surrounded by a three-dimensional shear layer and a pair of low- and high-speed streaks on each of its sides. Results from the global stability analyses highlight the unstable nature of the central low-speed region and its crucial importance in the laminar–turbulent transition process. It is able to sustain two different global instabilities: a sinuous and a varicose one. Each of these globally unstable modes is related to a different physical mechanism. While the varicose mode has its root in the instability of the whole three-dimensional shear layer surrounding the central low-speed region, the sinuous instability turns out to be similar to the von Kármán instability in the two-dimensional cylinder wake and has its root in the lateral shear layers of the separated zone. The aspect ratio of the roughness element plays a key role on the selection of the dominant instability: whereas the flow over thin cylindrical roughness elements transitions due to a sinuous instability of the near-wake region, for larger roughness elements the varicose instability of the central low-speed region turns out to be the dominant one. Direct numerical simulations of the flow past an aspect ratio ${\it\eta}=1$ (with ${\it\eta}=d/h$) roughness element sustaining only the sinuous instability have revealed that the bifurcation occurring in this particular case is supercritical. Finally, comparison of the transition thresholds predicted by global linear stability analyses with the von Doenhoff–Braslow transition diagram provides qualitatively good agreement.
Suction–shear–Coriolis instability in a flow between parallel plates
Authors: Deguchi Kengo , Matsubara Naoyoshi , Nagata Masato 
Published: November 2014

AbstractA rotating fluid flow between differentially translating parallel plates, which induce uniform suction and injection, is studied as a canonical model of swirling flow where suction, shear and Coriolis effects compete. This relatively simple modelling yields several reduced equations that are valid for asymptotically large suction, shear and/or rotation rates. The linear stability problems derived from the full Navier–Stokes and reduced problems are numerically solved and compared. In addition to Taylor-vortex modes, transverse-roll-type instabilities are found in Rayleigh-stable and -unstable parameter regions when weak suction is applied. These instabilities, separated by the so-called Rayleigh line, are characterised by vortices attached to the suction wall. Another type of instability, which exists beyond the Rayleigh line and shows inviscid motion in the fluid core, is found when suction is sufficiently strong. The relation of this instability to the stability results by Gallet, Doering & Spiegel (Phys. Fluids, vol. 22, 2010, 034105) is discussed. Our nonlinear analyses indicate subcritical and supercritical bifurcations of finite-amplitude solutions for the near-wall and fluid-core instabilities, respectively.
Impact of removing iodised salt on children's goitre status in areas with excessive iodine in drinking-water
Authors: Lv Shengmin , Xu Dong , Wang Yuchun , Jun Zhao , Jia Lihui , Du Yonggui 
Published: November 2014

The impact of removing iodised salt on children's goitre status in a high-iodine area (HIA) remains unclear. The aim of the present study was to explore the changes in the prevalence of goitre in children after removing iodised salt from their diet. For this purpose, three towns with the median water iodine content of 150–300 μg/l were selected randomly in Hengshui City, Hebei Province, China. A total of 452 and 459 children were randomly selected from the three towns in order to measure thyroid volume by ultrasound before and after removing iodised salt, respectively. Their goitre status was judged using the criteria of age-specific thyroid volume recommended by the WHO. After removing iodised salt, the overall median urinary iodine content (MUIC) of children decreased from 518 (interquartile range (IQR) 347–735) to 416 (IQR 274–609) μg/l. The MUIC of children across sex and age group decreased significantly except for the age group of 9 years. The overall prevalence of goitre in the three towns significantly decreased from 24·56 % (n 111/452) to 5·88 % (n 27/459) (P< 0·001). Goitre prevalence in children aged 8–10 years decreased from 33·70 % (n 31/92), 23·32 % (n 45/193) and 20·96 % (n 35/167) to 6·10 % (n 10/164), 5·52 % (n 9/163) and 6·06 % (n 8/132), respectively. Goitre prevalence in boys and girls decreased from 27·05 % (n 66/244) and 21·63 % (n 45/208) to 6·66 % (n 15/226) and 5·15 % (n 12/233), respectively. The decreases in the prevalence of goitre in children across sex and age group were all statistically significant. The present study revealed that goitre prevalence in children decreased significantly after removing iodised salt from their diet for about 1·5 years in the HIA in Hebei Province.
The greatest possible being needn't be anything impossible
Authors: TODD PATRICK 
Published: November 2014

AbstractThere are various argumentative strategies for advancing the claim that God does not exist. One such strategy is this. First, one notes that God is meant to have a certain divine attribute (such as omniscience). One then argues that having the relevant attribute is impossible. One concludes that God doesn't exist. For instance, Dennis Whitcomb's recent paper, ‘Grounding and omniscience’, proceeds in exactly this way. As Whitcomb says, ‘I'm going to argue that omniscience is impossible and that therefore there is no God.’ This is not, I hope to show, a very promising way to start a paper. If having a given property is impossible, the greatest possible being need not have that property. Accordingly, the argumentative strategy in question is doomed to failure. The upshot of this article is a quite general one concerning how arguments against the existence of God in fact must proceed.
Spatio-temporal investigation of the 1918 influenza pandemic in military populations indicates two different viruses
Authors: SHANKS G. D. , MILINOVICH G. J. , WALLER M. , CLEMENTS A. C. A. 
Published: November 2014

SUMMARYThere were multiple waves of influenza-like illness in 1918, the last of which resulted in a highly lethal pandemic killing 50 million people. It is difficult to study the initial waves of influenza-like illness in early 1918 because few deaths resulted and few morbidity records exist. Using extant military mortality records, we constructed mortality maps based on location of burial in France and Belgium in the British Army, and on home town in Vermont and New York in the USA Army. Differences between early and more lethal later waves in late 1918 were consistent with historical descriptions in France. The maps of Vermont and New York support the hypothesis that previous exposure may have conferred a degree of protection against subsequent infections; soldiers from rural areas, which were likely to have experienced less mixing than soldiers from urban areas, were at higher risk of mortality. Differences between combat and disease mortality in 1918 were consistent with limited influenza virus circulation during the early 1918 wave. We suggest that it is likely that more than one influenza virus was circulating in 1918, which might help explain the higher mortality rates in those unlikely to have been infected in early 1918.
The Impact of Precipitation on Land Interfacility Transport Times
Authors: Giang Wayne C. W. , Donmez Birsen , Ahghari Mahvareh , MacDonald Russell D. 
Published: November 2014

AbstractIntroductionTimely transfer of patients among facilities within a regionalized critical-care system remains a large obstacle to effective patient care. For medical transport systems where dispatchers are responsible for planning these interfacility transfers, accurate estimates of interfacility transfer times play a large role in planning and resource-allocation decisions. However, the impact of adverse weather conditions on transfer times is not well understood.Hypothesis/ProblemPrecipitation negatively impacts driving conditions and can decrease free-flow speeds and increase travel times. The objective of this research was to quantify and model the effects of different precipitation types on land travel times for interfacility patient transfers. It was hypothesized that the effects of precipitation would accumulate as the distance of the transfer increased, and they would differ based on the type of precipitation.MethodsUrgent and emergent interfacility transfers carried out by the medical transport system in Ontario from 2005 through 2011 were linked to Environment Canada's (Gatineau, Quebec, Canada) climate data. Two linear models were built to estimate travel times based on precipitation type and driving distance: one for transfers between cities (intercity) and another for transfers within a city (intracity).ResultsPrecipitation affected both transfer types. For intercity transfers, the magnitude of the delays increased as driving distance increased. For median-distance intercity transfers (48 km), snow produced delays of approximately 9.1% (3.1 minutes), while rain produced delays of 8.4% (2.9 minutes). For intracity transfers, the magnitude of delays attributed to precipitation did not depend on distance driven. Transfers in rain were 8.6% longer (1.7 minutes) compared to no precipitation, whereas only statistically marginal effects were observed for snow.ConclusionPrecipitation increases the duration of interfacility land ambulance travel times by eight percent to ten percent. For transfers between cities, snow is associated with the longest delays (versus rain), but for transfers within a single city, rain is associated with the longest delays.GiangWCW, DonmezB, AhghariM, MacDonaldRD. The impact of precipitation on land interfacility transport times. Prehosp Disaster Med. 2014;29(6):1-7.
Hyperbaric oxygen for long-term complications of radiation cystitis
Authors: Ferreira Carlos , Reis Frederico , Correia Tiago , Cardoso André , Cerqueira Manuel , Almeida Martinho , Prisco Rui , Camacho Oscar 
Published: November 2014

AbstractIntroductionBladder complications may be seen in up to 12% of patients treated with pelvic irradiation. To report the long-term efficacy of hyperbaric oxygen therapy (HBOT) on radiation-induced cystitis.MethodsWe followed 70 patients diagnosed with radiation cystitis submitted to HBOT in our institution from 2007 to 2013. All patients answered a questionnaire documenting symptom severity pre-HBOT and at the end of the follow-up period using the Late Effects of Normal Tissues – Subjective, Objective, Management, Analytical (LENT-SOMA) scale. Our treatment protocol consisted of multiple sessions (median of 40) of 100% oxygen delivery in a multiplace hyperbaric chamber at 2·4 atm for 80 minutes.ResultsWith a median follow-up of 55·5 (4–85) months, the success rate after the follow-up period in terms of haematuria resolution or improvement was 91·4%. The mean score of each subjective variable of LENT-SOMA scale (dysuria, frequency, haematuria, incontinence) were significantly lower after the follow-up period (p<0·05) with the exception of decreased stream (p=0·14). The sum of all subjective scores of LENT-SOMA scale was also significantly lower after the follow-up period (p<0·05). No serious complications were observed.ConclusionsOur results highlight the safety and long-term benefits of HBOT on haemorrhagic radiation cystitis and other distressful bladder symptoms.
Patterns of Ministry of Clergy Married to Clergy in the Church of England
Authors: Collingridge Susie 
Published: November 2014

AbstractThis article argues that for good practice, well-being and fruitful ministry, decisions by and about clergy married to clergy (CMC) in the Church of England require a clear quantitative picture of their ministry, and offers such a picture in early 2013 drawn primarily from published data, compared with national Church of England statistics. Over 26 per cent more clergy dyads were found than previously thought, with many active in ministry. A wide variety of ministry patterns were identified, including a higher than normal percentage in non-parochial roles, supporting previous research noting high levels of boundary enmeshment and absorptiveness. Considerable gender inequality prevailed in shared parochial settings in spite of women having been ordained priest for nearly 20 years, with very few wives holding more senior positions than their husbands, while female CMC are more likely to be dignitaries than other ordained women.
Separating sensitivity from exposure in assessing extinction risk from climate change
Authors: Dickinson Maria G. , Orme C. David L. , Suttle K. Blake , Mace Georgina M. 
Published: November 2014

AbstractPredictive frameworks of climate change extinction risk generally focus on the magnitude of climate change a species is expected to experience and the potential for that species to track suitable climate. A species' risk of extinction from climate change will depend, in part, on the magnitude of climate change the species experiences, its exposure. However, exposure is only one component of risk. A species' risk of extinction will also depend on its intrinsic ability to tolerate changing climate, its sensitivity. We examine exposure and sensitivity individually for two example taxa, terrestrial amphibians and mammals. We examine how these factors are related among species and across regions and how explicit consideration of each component of risk may affect predictions of climate change impacts. We find that species' sensitivities to climate change are not congruent with their exposures. Many highly sensitive species face low exposure to climate change and many highly exposed species are relatively insensitive. Separating sensitivity from exposure reveals patterns in the causes and drivers of species' extinction risk that may not be evident solely from predictions of climate change. Our findings emphasise the importance of explicitly including sensitivity and exposure to climate change in assessments of species' extinction risk.
ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth
Authors: Kiehl Steffen , Herkt Stefanie C. , Richter Antje M. , Fuhrmann Liesa , El-Nikhely Nefertiti , Seeger Werner , Savai Rajkumar , Dammann Reinhard H. 
Published: November 2014

AbstractEpigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation of ABCB4 in 26 human lung, breast, skin, liver, head and neck cancer cells lines and in primary cancers by methylation and expression analysis. Hypermethylation of the ABCB4 CpG island promoter occurred in 16 out of 26 (62%) human cancer cell lines. Aberrant methylation of ABCB4 was also revealed in 39% of primary lung cancer and in 20% of head and neck cancer tissues. In 37% of primary lung cancer samples, ABCB4 expression was absent. For breast cancer a significant hypermethylation occurred in tumor tissues (41%) compared to matching normal samples (0%, p = 0.002). Silencing of ABCB4 was reversed by 5-aza-2'-deoxycytidine and zebularine treatments leading to its reexpression in cancer cells. Overexpression of ABCB4 significantly suppressed colony formation and proliferation of lung cancer cells. Hypermethylation of Abcb4 occurred also in murine cancer, but was not found in normal tissues. Our findings suggest that ABCB4 is a frequently silenced gene in different cancers and it may act tumor suppressivly in lung cancer.
Plasmonic black metals via radiation absorption by two-dimensional arrays of ultra-sharp convex grooves
Authors: Beermann Jonas , Eriksen René L. , Holmgaard Tobias , Pedersen Kjeld , Bozhevolnyi Sergey I. 
Published: November 2014

AbstractPlasmonic black surfaces formed by two-dimensional arrays of ultra-sharp convex metal grooves, in which the incident radiation is converted into gap surface plasmon polaritons (GSPPs) and subsequently absorbed (via adiabatic nanofocusing), are fabricated and investigated experimentally for gold, nickel and palladium, using scanning electron microscopy, optical microscopy and reflection spectroscopy for their characterization. Absolute reflectivity spectra obtained for all fabricated arrays demonstrate very efficient and broadband absorption of unpolarized light exceeding the level of 95%, averaged over the investigated wavelength range of 400–985 nm. The highest averaged absorption level (~97%) is achieved with 250-nm-period arrays in palladium that also has the highest melting temperature (~1552°C), promising thereby potential applications for broadband absorption, e.g., within thermophotovoltaics. For one-dimensional arrays, GSPPs are excited only with the electric field polarized perpendicular to the groove orientation, resulting in 94–96% absorption of the appropriately polarized light for the arrays in nickel and palladium while featuring practically flat surface reflectivity spectra for the orthogonal polarization. The largest ratio (~10.7) between averaged reflectivities for orthogonal polarizations is achieved with the groove arrays in palladium, pointing thereby towards applications as broadband and low-dispersion linear polarizers operating in reflection, e.g., within ultra-fast optics.
Synthesis and formation mechanism of Zn2SiO4 nanorods
Authors: Zhang Shaoyan , Kang Haiyan , Gao Yanlei 
Published: November 2014

Zinc silicate (Zn2SiO4) nanorods with diameters of 90–100 nm and lengths of up to 600–700 nm have been successfully prepared by a simple hydrothermal route without the assistance of any templates or surfactants. The characterisations of the products were carried out by X‐ray diffraction (XRD), field‐emission scanning electron microscopy and transmission electron microscopy technology. On the basis of XRD and scanning electron microscopy analyses of the products at different reaction time periods, an Ostwald ripening mechanism is proposed to elucidate the formation mechanism of the nanorod structure. The electrochemical performance of the as‐prepared Zn2SiO4 nanorods was investigated by a galvanostatic charge–discharge method. The results have shown that the Zn2SiO4 nanorods exhibited a higher discharge capacity and better cyclability than the Zn2SiO4 bulk materials.
Overtone-based pitch selection in hermit thrush song: Unexpected convergence with scale construction in human music
Authors: Doolittle Emily L. , Gingras Bruno , Endres Dominik M. , Fitch W. Tecumseh 
Published: November 2014

Significance
The song of the hermit thrush, a common North American songbird, is renowned for its apparent musicality and has attracted the attention of musicians and ornithologists for more than a century. Here we show that hermit thrush songs, like much human music, use pitches that are mathematically related by simple integer ratios and follow the harmonic series. Our findings add to a small but growing body of research showing that a preference for small-integer ratio intervals is not unique to humans and are thus particularly relevant to the ongoing nature/nurture debate about whether musical predispositions such as the preference for consonant intervals are biologically or culturally driven.
Microtubules stabilize cell polarity by localizing rear signals
Authors: Zhang Jian , Guo Wei-Hui , Wang Yu-Li 
Published: November 2014

Significance
We discovered that cells on micropatterned strips change from highly persistent migration into striking oscillations upon the disassembly of microtubules. The oscillation phenomenon then allowed us to apply computer modeling to understand how the positive feedback in the local-excitation–global-inhibition (LEGI) mechanism, responsible for the persistence of migration, might be converted into negative feedback to drive oscillations upon the disassembly of microtubules. Our analyses led to the conclusion that microtubules facilitate the transport of inhibitory signals and their global distribution. Depending on the relative position of excitation and inhibitory signals, the resulting feedback in the integrated control circuit may be either positive or negative. Our finding therefore provides important insights into the role of microtubules in the control circuit of cell migration.
Probabilistic cognition in two indigenous Mayan groups
Authors: Fontanari Laura , Gonzalez Michel , Vallortigara Giorgio , Girotto Vittorio 
Published: November 2014

SignificanceCorrect probabilistic evaluations are one of the hallmarks of rationality. Is the human ability to make them dependent on formal education, or does it emerge regardless of instruction and culture? This paper shows that preliterate and prenumerate Mayan adults are able to solve a variety of probabilistic problems. These individuals correctly use prior and posterior information, proportions and elementary combinatorial procedures to predict the occurrence of random outcomes. And they perform like Mayan school children and Western controls. The finding that adults with no formal education are able to make suitable predictions indicates that, regardless of schooling and culture, the human mind possesses a basic probabilistic knowledge.