bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Preparation of 2,3‐Dihydroquinazolin‐4(1H)‐one Derivatives in Aqueous Media with β‐Cyclodextrin‐SO3H as a Recyclable Catalyst.
Authors: Wu Jian , Du Xianli , Ma Juan , Zhang Yuping , Shi Qingcai , Luo Lijun , Song Baoan , Yang Song , Hu Deyu 
Published: November 2014

AbstractA novel methodology for the synthesis of title compounds such as (III), (V), (IX), and (X) by ring closure of 2‐aminobenzamides (I) with aldehydes (II) or ketones (IV) is described.
ChemInform Abstract: Pd‐Catalyzed Dehydrogenative Cross‐Coupling of Pyridine‐N‐Oxides with Uracils.
Authors: Kianmehr Ebrahim , Rezaeefard Masoud , Rezazadeh Khalkhali Mehran , Khan Khalid Mohammed 
Published: November 2014

AbstractAn efficient protocol is developed for the synthesis of uracil substituted pyridine‐N‐oxides which can be readily deoxygenated to give the corresponding pyridines.
ChemInform Abstract: AgI Nanoparticles as a Remarkable Catalyst in the Synthesis of (Amidoalkyl)naphthol and Oxazine Derivatives: An Eco‐Friendly Approach.
Authors: Safaei Ghomi Javad , Zahedi Safura , Ghasemzadeh Mohammad Ali 
Published: November 2014

AbstractFacile and environmentally friendly routes for the synthesis of amidoalkylnaphthol (VII) and related oxazine derivatives [cf.
ChemInform Abstract: Task‐Specific Ionic Liquid‐Mediated Facile Synthesis of 1,3,5‐Triaryltriazines by Cyclotrimerization of Imines and Their Biological Evaluation.
Authors: Dandia Anshu , Jain Anuj K. , Sharma Sonam 
Published: November 2014

AbstractThe ionic liquid is recycled and reused without decreasing yields.
ChemInform Abstract: Cascade Nitrosation and Addition—Elimination of Nitroacetanilides for the Highly Efficient Synthesis of 1,4,2,5‐Dioxadiazine Derivatives.
Authors: Mo Shanyan , Huang Peipei , Xu Jiaxi 
Published: November 2014

AbstractThe key intermediate is the aci‐nitroso species, which is stabilized by the conjugated aryl moiety.
ChemInform Abstract: Rhodium(III)‐Catalyzed Intramolecular Amidoarylation and Hydroarylation of Alkyne via C—H Activation: Switchable Synthesis of 3,4‐Fused Tricyclic Indoles and Chromans.
Authors: Zhang Xue , Li Yifei , Shi Hui , Zhang Lunan , Zhang Shanshan , Xu Xianxiu , Liu Qun 
Published: November 2014

AbstractThe amidoarylation pathway is sensitive to the electronic effect of the alkyne substituent, whereas the E‐selective hydroarylation pathway is relatively insensitive to electronic as well as steric effects of the substituents.
ChemInform Abstract: P(n‐Bu)3 Catalyzed Reactions of Salicyl N‐Thiophosphinyl Imines with Allenylphosphonates: Synthesis of Phosphono‐Chromans.
Authors: Rama Suresh R. , Prasad Tulichala R. N. , Kotikalapudi Ramesh , Kumara Swamy K. C. 
Published: November 2014

AbstractOptimum reaction conditions are examined for the reaction of N‐thiophosphinyl imines (I) with allenylphosphonates (II) or (V).
ChemInform Abstract: Total Synthesis of Panaginsene with Structural Revision.
Authors: Geum Sujeong , Lee Hee‐Yoon 
Published: November 2014

AbstractIn order to confirm the proposed structure of the tricyclic sesquiterpene panaginsene (I), which is isolated from the roots of Panax ginseng, the total synthesis of (I) and its epimer (II) is described.
ChemInform Abstract: NF‐ϰB Inhibitory Activity of Polyoxygenated Steroids from the Vietnamese Soft Coral Sarcophyton pauciplicatum.
Authors: Thao Nguyen Phuong , Luyen Bui Thi Thuy , Sun Ya Nan , Song Seok Bean , Thanh Nguyen Van , Cuong Nguyen Xuan , Nam Nguyen Hoai , Kiem Phan Van , Kim Young Ho , Minh Chau Van 
Published: November 2014

AbstractThe new steroid sarcopanol A (I) is isolated along with two known polyhydroxylated steroids from the soft coral Sacrophyton pauciplicatum.
ChemInform Abstract: New Acylphloroglucinol Derivatives with Diverse Architectures from Hypericum henryi.
Authors: Yang Xing‐Wei , Ding Yuanqing , Zhang Jing‐Jing , Liu Xia , Yang Li‐Xin , Li Xiao‐Nian , Ferreira Daneel , Walker Larry A. , Xu Gang 
Published: November 2014

AbstractHyphenrones A‐F (I)‐(V) are isolated from the title plant.
ChemInform Abstract: Structural Changes Concurrent with Ferromagnetic Transition
Authors: Yang Sen , Bao Hui‐Xin , Chao Zhou , Yu Wang , Ren Xiao‐Bing , Song Xiao‐Ping , Matsushita Yoshitaka , Katsuya Yoshio , Tanaka Masahiko , Kobayashi Keisuke 
Published: November 2014

AbstractReview: this review is intended to give a self‐consistent and logical account of strucural change occurring simultaneously with a ferromagnetic transition, which may provide new insight for developing highly magneto‐responsive materials; 75 refs
Combined composite likelihood
Authors: Kenne Pagui Euloge Clovis , Salvan Alessandra , Sartori Nicola 
Published: November 2014

AbstractComposite likelihood appears to be an appealing alternative to the full likelihood when the latter is too complex. For a given model, there may be different ways to formulate a composite likelihood, for example, pairwise marginal or conditional likelihood. To guide the choice, we develop a suggestion in Cox & Reid (2004) and we explore a combination of pairwise and independence likelihoods which leads to a new objective function that depends on a constant to be chosen. Exact and asymptotic properties are explored. The former allow to identify a range of admissible values for the constant, while efficiency considerations can be used to choose an optimal value. Two examples are analysed in detail, also through simulation studies.The Canadian Journal of Statistics42: 525–543; 2014 © 2014 Statistical Society of Canada
Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97–p47 Complex
Authors: Fang Chen‐Jie , Gui Lin , Zhang Xiaoyi , Moen Derek R. , Li Kelin , Frankowski Kevin J. , Lin Henry J. , Schoenen Frank J. , Chou Tsui‐Fen 
Published: November 2014

AbstractWe previously found that p97 ATPase inhibitors 2‐(2‐amino‐1H‐benzo[d]imidazol‐1‐yl)‐N‐benzyl‐8‐methoxyquinazolin‐4‐amine (ML240) and 2‐(2H‐benzo[b][1,4]oxazin‐4(3H)‐yl)‐N‐benzyl‐5,6,7,8‐tetrahydroquinazolin‐4‐amine (ML241) specifically target the D2 domain of wild‐type p97. In addition, one of the major p97 cofactors, p47, decreases their potencies by ∼50‐fold. In contrast, N2,N4‐dibenzylquinazoline‐2,4‐diamine (DBeQ) targets both the D1 and D2 domains and shows only a four‐ to sixfold decrease in potency against the p97–p47 complex. To elucidate structure–activity relationships for the inhibitors, we screened 200 p97 inhibitor analogues for their ability to inhibit the ATPase activity of either or both of the D1 or D2 domains, as well for their effects on p47 potency. The selectivity of 29 of these compounds was further examined by eight‐dose titrations. Four compounds showed modest selectivity for inhibiting the ATPase activity of D1. Eleven compounds inhibited D2 with greater potencies, and four showed similar potencies against D1 and D2. p47 decreased the potencies of the majority of the compounds and increased the potencies of five compounds. These results highlight the possibility of developing domain‐selective and complex‐specific p97 inhibitors in order to further elucidate the physiological roles of p97 and its cofactors.
Bringing PROMIS to practice: Brief and precise symptom screening in ambulatory cancer care
Authors: Wagner Lynne I. , Schink Julian , Bass Michael , Patel Shalini , Diaz Maria Varela , Rothrock Nan , Pearman Timothy , Gershon Richard , Penedo Frank J. , Rosen Steven , Cella David 
Published: November 2014

BACKGROUNDSupportive oncology practice can be enhanced by the integration of a brief and validated electronic patient‐reported outcome assessment into the electronic health record (EHR) and clinical workflow.METHODSSix hundred thirty‐six women receiving gynecologic oncology outpatient care received instructions to complete clinical assessments through Epic MyChart, an EHR patient communication portal. Patient Reported Outcomes Measurement Information System (PROMIS) computer adaptive tests (CATs) were administered to assess fatigue, pain interference, physical function, depression, and anxiety. Checklists identified psychosocial concerns, informational and nutritional needs, and risk factors for inadequate nutrition. Assessment results, including PROMIS T scores with documented severity thresholds, were immediately populated in the EHR. Clinicians were notified of clinically elevated symptoms through EHR messages. EHR integration was designed to provide automated triage to social work providers for psychosocial concerns, to health educators for information, and to dietitians for nutrition‐related concerns.RESULTSFour thousand forty‐two MyChart messages sent, and 3203 (79%) were reviewed by patients. The assessment was started by 1493 patients (37%), and once they started, 93% (1386 patients) completed the assessment. According to first assessments only, 49.8% of the patients who reviewed the MyChart message completed the assessment. Mean PROMIS CAT T scores indicated a lower level of physical function and elevated anxiety in comparison with the general population. Fatigue, pain, and depression scores were comparable to those of the general population. Impaired physical functioning was the most common basis for clinical alerts and occurred in 4% of the patients.CONCLUSIONSPROMIS CATs were used to measure common cancer symptoms in routine oncology outpatient care. Immediate EHR integration facilitated the use of symptom reporting as the basis for referral to psychosocial and supportive care. Cancer 2015;121:927–934. © 2014 American Cancer Society.
Impact of colorectal cancer diagnosis and treatment on health‐related quality of life among older Americans: A population‐based, case‐control study
Authors: Quach Caroleen , Sanoff Hanna K. , Williams Grant R. , Lyons Jessica C. , Reeve Bryce B. 
Published: November 2014

BACKGROUNDData on health‐related quality of life (HRQoL) changes among Americans aged ≥65 following colorectal cancer (CRC) diagnosis and treatment are limited. This study compared HRQoL changes among CRC patients across stages from before to after diagnosis with matched noncancer controls.METHODSThis population‐based study used the Surveillance, Epidemiology, and End Results Medicare Health Outcomes Survey (MHOS) data set (1998‐2007). Medicare Advantage beneficiaries diagnosed with CRC between their baseline and follow‐up MHOS (n = 349) were matched to noncancer controls (n = 1745) using propensity scores. Mixed‐effects analysis of covariance models estimated changes in HRQoL (measured by the Medical Outcomes Study Short Form‐36/Veterans RAND 12‐item Survey) and the ability to perform 6 activities of daily living (ADLs) between baseline and follow‐up. Logistic regression models estimated odds ratios for ADL impairments and major depressive disorder (MDD) risk.RESULTSMean time between CRC diagnosis and follow‐up MHOS was 12.3 ± 9.8 months. Compared with controls, CRC patients had significantly lower scores in all physical and mental health domains at follow‐up. The greatest decrements were observed in physical health and were largely driven by declines in the 6 months postdiagnosis and in stage III and IV patients. At follow‐up, CRC patients had greater overall ADL impairment and difficulty with dressing, eating, and getting in/out of chairs. CRC patients, particularly stage IV patients, had greater odds of being at risk for MDD relative to controls.CONCLUSIONSThis study further underscores the adverse effects of CRC on physical health and the need to support older Americans' basic self‐care needs, with attention to later‐stage patients' increased debility. Cancer 2015;121:943–950. © 2014 American Cancer Society.
Experiencing reproductive concerns as a female cancer survivor is associated with depression
Authors: Gorman Jessica R. , Su H. Irene , Roberts Samantha C. , Dominick Sally A. , Malcarne Vanessa L. 
Published: November 2014

BACKGROUNDYoung adult female cancer survivors have unmet reproductive concerns and informational needs that are associated with poorer quality of life. The purpose of this study was to examine the association between current reproductive concerns and moderate to severe depression among young survivors.METHODSThis cross‐sectional study included 200 female cancer survivors between the ages of 18 and 35 years who completed a Web‐based survey measuring reproductive history, parenthood desires, reproductive concerns after cancer, and quality‐of‐life indicators.RESULTSThe mean age of the participants was 28 years (standard deviation, 4.4 years), and almost two‐thirds were diagnosed within 5 years of survey completion. A multivariate logistic regression analysis controlling for education, duration of survivorship, and social support revealed an association between experiencing reproductive concerns and moderate to severe depression (odds ratio for each 5‐unit increase in the Reproductive Concerns After Cancer [RCAC] score, 1.30; 95% confidence interval, 1.06‐1.60). Among those with moderate to severe depression, 23% had high RCAC scores, whereas 6% of those with minimal to mild depression did (P < .001).CONCLUSIONSA higher level of reproductive concerns was associated with greater odds of experiencing moderate to severe depression. Almost a quarter of survivors in this sample reported moderate to severe depression, and addressing reproductive concerns represents one potential area of intervention for improving the psychosocial health of young survivors. Cancer 2015;121:935–942. © 2014 American Cancer Society.
Significant association between human osteosarcoma and simian virus 40
Authors: Mazzoni Elisa , Benassi Maria Serena , Corallini Alfredo , Barbanti‐Brodano Giovanni , Taronna Angelo , Picci Piero , Guerra Giovanni , D'Agostino Antonio , Trevisiol Lorenzo , Nocini Pier Francesco , Casali Maria Vittoria , Barbanti‐Brodano Giuseppe , Martini Fernanda , Tognon Mauro 
Published: November 2014

BACKGROUNDSimian virus 40 (SV40) has been considered to be an oncogenic viral agent in the development of osteosarcoma (OS), which to the authors' knowledge continues to be of unknown etiology.METHODSIn the current study, serum samples from patients with OS were investigated with an indirect enzyme‐linked immunoadsorbent assay (ELISA) to test for the presence of immunoglobulin G antibodies, which react with SV40 antigens. In ELISA, SV40 antigens were represented by 2 synthetic polypeptides that mimic epitopes of the viral capsid proteins 1 to 3. Additional sera from patients with breast cancer and undifferentiated nasopharyngeal carcinoma as well as healthy subjects were the controls.RESULTSImmunologic results suggested that antibodies that react with SV40 mimotopes were more prevalent (44%) in serum samples from patients with OS compared with healthy subjects (17%). The difference in prevalence between these cohorts was statistically significant (P<.001). It is interesting to note that in the patients with OS, significance indicated the difference between OS versus breast cancer (44% vs 15%; P<.001) and OS versus undifferentiated nasopharyngeal carcinoma (44% vs 25%; P<.05).CONCLUSIONSThe data from the current study indicate an association between OS and SV40. These data could be transferred to clinical applications for innovative therapies to address SV40‐positive OS. Cancer 2015;121:708–715. © 2014 American Cancer Society.
One‐Step Synthesis and Polyacrylic Acid Functionalization of Multifunctional Europium‐Doped NaGdF4 Nanoparticles with Selected Size for Optical and MRI Imaging
Authors: Nuñez Nuria O. , García María , García‐Sevillano Jorge , Rivera‐Fernández Sara , de la Fuente Jesús M. , Ocaña Manuel 
Published: November 2014

AbstractMultifunctional Eu:NaGdF4 nanospheres functionalized with polyacrylic acid (PAA) polymer have been prepared for the first time by a simple one‐pot method that consists of a homogeneous precipitation reaction at 120 °C. The size of the nanospheres, which were polycrystalline and crystallized into a hexagonal structure, could be altered in the 60–95 nm range by adjusting the amount of polyacrylic acid added. The effects of Eu content and particle size of these nanomaterials on their optical properties (emission intensity and lifetime) as well as on their relaxivity (r1 and r2) values were also analyzed to find the optimum system for optical bioimaging and as a positive contrast agent for magnetic resonance imaging (MRI) applications. Finally, such optimum nanoparticles showed negligible cytotoxicity for Vero cells for concentrations up to 0.5 mg mL–1 and a high colloidal stability in 2‐morpholinoethanesulfonic acid solutions, thereby satisfying the most important requirements for their use in biotechnological applications.
Automated Determination of Cu(II), Pb(II), Cd(II) and Zn(II) in Environmental Samples by Square Wave Voltammetry Exploiting Sequential Injection Analysis and Screen Printed Electrodes
Authors: Ribeiro Luiz Fernando , Masini Jorge Cesar 
Published: November 2014

AbstractThis paper describes the development of a methodology for quantification of Cu(II), Pb(II), Cd(II) and Zn(II) in waters and sediments by anodic stripping voltammetry (ASV) automated by Sequential Injection Analysis (SIA) using a graphite screen printed sensor modified with mercury. Determinations were made by standard addition automated by the SIA system. The limits of detection and quantification were, respectively, 1.3 and 4.3 µg L−1 for Cu(II), 1.4 and 4.6 µg L−1 for Pb(II), 0.6 and 1.8 µg L−1 for Cd(II) and 4.2 and 14 µg L−1 for Zn(II). These limits were obtained for a sample volume of 1000 µL, flow rate of 10 µL s−1 (during the deposition step), and utilizing 3 flow reversals (volume of reversion=950 µL), totalizing a deposition time of 315 s. The potentiostat worked synchronically with the SIA system applying the conditioning potential of −0.1 V vs. pseudo reference of Ag (100 s), deposition potential of −1.0 V for Cu(II), Pb(II) and Cd(II) or −1,3 V for Zn(II), square wave frequency of 100 Hz, potential step of 6 mV and pulse height of 40 mV. For quantification of Zn(II) in sediment extracts, deposition of Ga0 on the working electrode was necessary to avoid the formation of intermetallic between Zn0 and Cu0. The accuracy of the method was assessed by spike and recovery experiments in water samples which resulted recovery rates near 100 % of the spiked concentrations. Recoveries of concentrations in the certified sediment sample CRM‐701 undergoing the three steps sequential extraction procedure of BCR varied from 71.7 % for Zn(II) in the acetic acid extract to 112.4 % for Cu(II) in the oxidisable fraction, confirming that the standard addition approach corrected the matrix effects in the complex samples of sediment extracts.
Activity‐Related Parenting Practices: Development of the Parenting Related to Activity Measure (PRAM) and Links with Mothers' Eating Psychopathology and Compulsive Exercise Beliefs
Authors: Haycraft Emma , Powell Faye , Meyer Caroline 
Published: November 2014

AbstractThis is a two‐study paper that developed a measure to assess parenting practices related to children's physical activity and explored maternal predictors of such parenting practices. Study 1: A self‐report measure of parents' activity‐related practices (the Parenting Related to Activity Measure) was developed, and a principal component analysis was carried out using data from 233 mothers of 4.5‐ to 9‐year‐old children. The results supported a six‐factor model and yielded the following subscales: Responsibility/monitoring; Activity regulation; Control of active behaviours; Overweight concern; Rewarding parenting; and Pressure to exercise. Study 2: Mothers (N = 170) completed the Parenting Related to Activity Measure, alongside measures of eating psychopathology and compulsive exercise, to identify predictors of activity‐related parenting practices. Mothers' eating psychopathology and exercise beliefs predicted activity parenting practices with their sons and daughters, but different predictors were seen for mothers of daughters versus sons. Mothers' eating and exercise attitudes are important predictors of their activity‐related parenting practices, particularly with girls. Identifying early interactions around activity/exercise could be important in preventing the development of problematic beliefs about exercise, which are often a key symptom of eating disorders. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.
An integrated assessment of habitat quality of national estuarine research reserves in the southeastern United States
Authors: Balthis W Leonard , Cooksey Cynthia , Fulton Michael F , Hyland Jeffrey L , Riekerk George HM , Van Dolah Robert F , Wirth Edward F 
Published: November 2014

Abstract
Multiple indicators of water quality, sediment quality, and biological condition were used to assess the status of ecological condition of National Estuarine Research Reserve System (NERRS) sites in North Carolina, South Carolina, and Georgia relative to a suite of corresponding scoring criteria. All measurements were made in subtidal aquatic habitats. Calculated scores were integrated into an overall index of habitat quality and used to make comparisons among the various NERR and nonNERR estuaries throughout the region. Sediment quality scores varied considerably among NERR sites, but in most cases were similar between individual NERR and non-NERR sites in corresponding states. Water quality and biological condition indicators scored consistently higher for NERRs versus non-NERR sites. Overall habitat quality scores also were consistently higher for NERRS sites, suggesting that these areas are on par with if not in slightly better condition ecologically than neighboring nonNERR estuaries. Portions of individual NERR sites rated as poor with respect to overall habitat quality were limited to relatively small areas (&lt;13% of a reserve's total sampling area). Integr Environ Assess Manag 2015;11:266–275. Published 2014 SETAC. This article is a US Government work and, as such, is in the public domain in the USA.
Key Points
The approach described in this paper provides a method of integrating measurements of multiple indicators of water quality, sediment quality, and biological condition into a single habitat quality index. The ability to combine a suite of indicators into easily-interpretable, easy-to-understand index represents a powerful management tool. The results of this study suggest that protected areas such as National Estuarine Research Reserves (NERRs) are in relatively good shape in comparison to neighboring estuaries.