bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel cathode interphase formation methodology by preferential adsorption of a borate-based electrolyte additive
Authors: Zhang Danfeng , Ma Jiabin , Zhang Chen , Liu Ming , Yang Ke , Li Yuhang , Cheng Xing , Wang Ziqiang , Wang Huiqi , Lv Wei , He Yan-Bing , Kang Feiyu 
Published: June 2024

ABSTRACT
The coupling of high-capacity cathodes and lithium metal anodes promises to be the next generation of high-energy-density batteries. However, the fast-structural degradations of the cathode and anode challenge their practical application. Herein, we synthesize an electrolyte additive, tris(2,2,3,3,3-pentafluoropropyl) borane (TPFPB), for ultra-stable lithium (Li) metal||Ni-rich layered oxide batteries. It can be preferentially adsorbed on the cathode surface to form a stable (B and F)-rich cathode electrolyte interface film, which greatly suppresses the electrolyte-cathode side reactions and improves the stability of the cathode. In addition, the electrophilicity of B atoms in TPFPB enhances the solubility of LiNO3 by 30 times in ester electrolyte to significantly improve the stability of the Li metal anode. Thus, the Li||Ni-rich layered oxide full batteries using TPFPB show high stability and an ultralong cycle life (up to 1500 cycles), which also present excellent performance even under high voltage (4.8 V), high areal mass loading (30 mg cm−2) and wide temperature range (−30∼60°C). The Li||LiNi0.9Co0.05Mn0.05O2 (NCM90) pouch cell using TPFPB with a capacity of 3.1 Ah reaches a high energy density of 420 Wh kg−1 at 0.1 C and presents outstanding cycling performance.
Three-dimensional quantum Griffiths singularity in bulk iron-pnictide superconductors
Authors: Liu Shao-Bo , Tian Congkuan , Cai Yongqing , Cui Hang , Wei Xinjian , Chen Mantang , Zhao Yang , Sui Yuan , Guan Shuyue , Jia Shuang , Zhang Yu , Feng Ya , Li Jiankun , Cui Jian , Song Yuanjun , Hao Tingting , Chen Chaoyu , Chen Jian-Hao 
Published: June 2024

ABSTRACT
The quantum Griffiths singularity (QGS) is a phenomenon driven by quenched disorders that break conventional scaling invariance and result in a divergent dynamic critical exponent during quantum phase transitions (QPT). While this phenomenon has been well-documented in low-dimensional conventional superconductors and in three-dimensional (3D) magnetic metal systems, its presence in 3D superconducting systems and in unconventional high-temperature superconductors (high-Tc SCs) remains unclear. In this study, we report the observation of robust QGS in the superconductor-metal transition (SMT) of both quasi-2D and 3D anisotropic unconventional high-Tc superconductor CaFe1-xNixAsF (x &lt;5%) bulk single crystals, where the QGS states persist to up to 5.3 K. A comprehensive quantum phase diagram is established that delineates the 3D anisotropic QGS of SMT induced by perpendicular and parallel magnetic fields. Our findings reveal the universality of QGS in 3D superconducting systems and unconventional high-Tc SCs, thereby substantially expanding the range of applicability of QGS.
Serologic Testing of US Blood Donations to Identify Severe Acute Respiratory Syndrome Coronavirus 2 and Other Coronaviruses, December 2019 to July 2020
Authors: Grimm Kacie , Saá Paula , Cheedarla Narayanaiah , Gerty Michael S , Groves Jamel A , Dodd Roger Y , Roback John , Stramer Susan L 
Published: June 2024

Abstract

Background
The first coronavirus disease 2019 (COVID-19) case in the United States was recognized on 19 January 2020, but the time of introduction of the virus into the United States is unknown. An existing sample cohort was examined for serologic evidence of early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

Methods
A repository of 46 120 samples from healthy routine blood donors, representing 46 states and the District of Columbia, was tested for total antibodies to SARS-CoV-2 nucleocapsid (anti-N) using a commercial test. All reactive samples were further tested using an experimental receptor-binding domain (RBD)–specific immunoglobulin G (IgG) enzyme-linked immunosorbent assay. Further testing was also conducted for anti-spike (anti-S) antibodies by commercial tests, experimental anti-S immunologic blocking, and for antibodies to the 4 human cold coronaviruses.

Results
Anti-N reactivity was observed in 92 tested samples (0.2%), 91 of which had adequate volume for further testing; of these, 55 were confirmed positive by anti-RBD. None of these reactive findings were attributable to the other human coronaviruses tested. The confirmed-positive frequency increased over time paralleling patterns observed for COVID-19 cases reported in the United States (in contrast to stable patterns over time for the cold coronaviruses). Nine confirmed positive samples (0.07%) were identified among the 13 364 donations collected between 13 December 2019 and 22 January 2020. None of these early confirmed-positive samples were reactive by commercial anti-S tests suggesting very recent infection.

Conclusions
The samples tested in this study were broadly representative of the United States, and all were from individuals who had successfully donated blood. The antibody-reactive results of this study suggest that SARS-CoV-2 was likely present in the United States before 19 January 2020.
Association Between Diagnostic Delays and Spinal Involvement in Human Brucellosis: A Retrospective Case-Control Study
Authors: Pu Zhongshu , Liu Yiwen , Bai Manling , Ling Tong , Pan Jing , Xu Dengrong , Dai Peijun , Yan Yongping 
Published: June 2024

Abstract

Background
Spinal involvement is a common but serious complication of human brucellosis. However, information on the risk factors associated with spinal involvement in individuals with brucellosis is limited.

Methods
This retrospective case-control study aimed to determine the potential risk factors associated with spinal complications in inpatients with brucellosis.

Results
During the study period, brucellosis was diagnosed in 377 patients, of whom 108 (28.64%) showed spinal involvement. Those with spinal involvement were significantly older than patients in the control group (mean age [standard deviation], 53.25 [10.48] vs 43.12 [13.84] years, respectively; P &lt; .001). The diagnostic delays were significantly longer in patients with spinal involvement than in the control group (mean delay [standard deviation], 11.17 [13.55] vs 6.03 [8.02] weeks; P = .001). Age &gt;40 years (odds ratio, 5.42 [95% confidence interval, 2.65–11.05]; P &lt; .001) and diagnostic delay &gt;4 weeks (2.94 [1.62–5.35]; P &lt; .001) were independently associated with spinal involvement in brucellosis. The lumbar spine at the L3–5 level was the most affected (152 of 249 [61.04%]). Back pain (92 of 108 in case patients vs 21 of 108 in controls; P &lt; .001) and splenomegaly (23 vs 42 of 108, respectively; P = .005) differed significantly between the 2 groups.

Conclusions
Age &gt;40 years and diagnostic delay &gt;4 weeks increased the risk of spinal involvement in brucellosis. Therefore, the time from symptom onset to diagnosis should be shortened, using effective measures to reduce spinal involvement risk.
Evaluation of administration-related reactions with subcutaneous daratumumab with and without premedication
Authors: Padmaraju Kashyap , Kelly Kaitlin , Jakubowiak Andrzej J , Derman Benjamin A 
Published: June 2024

Abstract

Background
Daratumumab-hyaluronidase-fihj (Dara-SQ) is frequently used in the treatment of plasma cell disorders and is associated with improved outcomes. Dara-SQ was shown to be non-inferior to intravenous daratumumab (Dara-IV) in efficacy, safety, and associated with fewer administration-related reactions (ARRs). Despite the lower ARR risk with Dara-SQ, package labeling still recommends indefinite premedication. In this study, we investigated the safety of premedication discontinuation after one cycle of Dara-SQ.

Materials and Methods
This pre-post interventional quality improvement study included all patients aged 18 years and older diagnosed with multiple myeloma or light chain (AL) amyloidosis who received at least one dose of Dara-SQ. Patients in Arm 1 received Dara-SQ per package labeling, while patients in Arm 2 had premedication omitted (excluding dexamethasone) after cycle 1. The primary endpoint was the incidence of ARR after cycle 1. Overall ARR rate and therapy time saved were also evaluated.

Results
A total of 102 patients (63 in Arm 1 and 39 in Arm 2) were included. There were zero reactions in either arm after cycle 1 across 1479 Dara-SQ doses administered over a 30-month period with or without premedication omission. The overall ARR rate was 2.9% (3/102), which all occurred prior to premedication omission. Therapy timed saved from premedication omission was 194 hours in a 6-month period, equating to approximately $140 000 USD.

Conclusion
ARRs to Dara-SQ were rare, mild, and occurred during cycle 1 prior to premedication omission. Omission of noncorticosteroid premedication is safe, feasible, and carries substantial time and cost savings for patients and infusion centers.
Molecular mechanisms underlying gene regulatory variation of maize metabolic traits
Authors: Chu Yi-Hsuan , Lee Yun Sun , Gomez-Cano Fabio , Gomez-Cano Lina , Zhou Peng , Doseff Andrea I , Springer Nathan , Grotewold Erich 
Published: June 2024

Abstract
Variation in gene expression levels is pervasive among individuals and races or varieties, and has substantial agronomic consequences, for example, by contributing to hybrid vigor. Gene expression level variation results from mutations in regulatory sequences (cis) and/or transcription factor (TF) activity (trans), but the mechanisms underlying cis- and/or trans-regulatory variation of complex phenotypes remain largely unknown. Here, we investigated gene expression variation mechanisms underlying the differential accumulation of the insecticidal compounds maysin and chlorogenic acid in silks of widely used maize (Zea mays) inbreds, B73 and A632. By combining transcriptomics and cistromics, we identified 1,338 silk direct targets of the maize R2R3-MYB TF Pericarp color1 (P1), consistent with it being a regulator of maysin and chlorogenic acid biosynthesis. Among these P1 targets, 464 showed allele-specific expression (ASE) between B73 and A632 silks. Allelic DNA-affinity purification sequencing identified 34 examples in which P1 allelic specific binding (ASB) correlated with cis-expression variation. From previous yeast one-hybrid studies, we identified 9 TFs potentially implicated in the control of P1 targets, with ASB to 83 out of 464 ASE genes (cis) and differential expression of 4 out of 9 TFs between B73 and A632 silks (trans). These results provide a molecular framework for understanding universal mechanisms underlying natural variation of gene expression levels, and how the regulation of metabolic diversity is established.
The U-box E3 ubiquitin ligase PUB35 negatively regulates ABA signaling through AFP1-mediated degradation of ABI5
Authors: Du Chang , Liu Meng , Yan Yujie , Guo Xiaoyu , Cao Xiuping , Jiao Yuzhe , Zheng Jiexuan , Ma Yanchun , Xie Yuting , Li Hongbo , Yang Chengwei , Gao Caiji , Zhao Qingzhen , Zhang Zhonghui 
Published: June 2024

Abstract
Abscisic acid (ABA) signaling is crucial for plant responses to various abiotic stresses. The Arabidopsis (Arabidopsis thaliana) transcription factor ABA INSENSITIVE 5 (ABI5) is a central regulator of ABA signaling. ABI5 BINDING PROTEIN 1 (AFP1) interacts with ABI5 and facilitates its 26S-proteasome-mediated degradation, although the detailed mechanism has remained unclear. Here, we report that an ABA-responsive U-box E3 ubiquitin ligase, PLANT U-BOX 35 (PUB35), physically interacts with AFP1 and ABI5. PUB35 directly ubiquitinated ABI5 in a bacterially reconstituted ubiquitination system and promoted ABI5 protein degradation in vivo. ABI5 degradation was enhanced by AFP1 in response to ABA treatment. Phosphorylation of the T201 and T206 residues in ABI5 disrupted the ABI5–AFP1 interaction and affected the ABI5–PUB35 interaction and PUB35-mediated degradation of ABI5 in vivo. Genetic analysis of seed germination and seedling growth showed that pub35 mutants were hypersensitive to ABA as well as to salinity and osmotic stresses, whereas PUB35 overexpression lines were hyposensitive. Moreover, abi5 was epistatic to pub35, whereas the pub35-2 afp1-1 double mutant showed a similar ABA response to the two single mutants. Together, our results reveal a PUB35–AFP1 module involved in fine-tuning ABA signaling through ubiquitination and 26S-proteasome-mediated degradation of ABI5 during seed germination and seedling growth.
Photoreceptor-induced sinapate synthesis contributes to photoprotection in Arabidopsis
Authors: Leonardelli Manuela , Tissot Nicolas , Podolec Roman , Ares-Orpel Florence , Glauser Gaétan , Ulm Roman , Demarsy Emilie 
Published: June 2024

Abstract
Plants must balance light capture for photosynthesis with protection from potentially harmful ultraviolet (UV) radiation. Photoprotection is mediated by concerted action of photoreceptors, but the underlying molecular mechanisms are not fully understood. In this study, we provide evidence that UV RESISTANCE LOCUS 8 (UVR8) UV-B, phytochrome red, and cryptochrome blue-light photoreceptors converge on the induction of FERULIC ACID 5-HYDROXYLASE 1 (FAH1) that encodes a key enzyme in the phenylpropanoid biosynthesis pathway, leading to the accumulation of UV-absorbing sinapate esters in Arabidopsis (Arabidopsis thaliana). FAH1 induction depends on the basic leucine zipper transcription factors ELONGATED HYPOCOTYL 5 (HY5) and HY5 HOMOLOG that function downstream of all 3 photoreceptors. Noticeably, mutants with hyperactive UVR8 signaling rescue fah1 UV sensitivity. Targeted metabolite profiling suggests that this phenotypic rescue is due to the accumulation of UV-absorbing metabolites derived from precursors of sinapate synthesis, namely, coumaroyl glucose and feruloyl glucose. Our genetic dissection of the phenylpropanoid pathway combined with metabolomic and physiological analyses show that both sinapate esters and flavonoids contribute to photoprotection with sinapates playing a major role for UV screening. Our findings indicate that photoreceptor-mediated regulation of FAH1 and subsequent accumulation of sinapate “sunscreen” compounds are key protective mechanisms to mitigate damage, preserve photosynthetic performance, and ensure plant survival under UV.
Epistemic infringement and the wrong of propagandizing
Authors: Leydon-Hardy Lauren 
Published: June 2024

Abstract
The first part of this paper presents a dilemma for arationalism about propaganda. Arationalists hold that propaganda is constitutively reliant on bypassing audience-side rationality. According to the twin pillars of arationalism, then, propaganda is distinguished by the arationalism of audience-side uptake, and criticizable for its circumvention of audience-side rationality. Here, I argue that if the twin pillars of arationalism hold, then arationalists must either deny that bald-faced propaganda is propaganda or deny that bald-faced propaganda is objectionable qua propaganda. Against arationalism, I argue that propagandizing is apt to epistemically infringe on an audience. Propagandizing constitutively involves the systematic contravention of the norms typifying the relationship between communicator and audience, with the characteristic effect of eroding the audience's epistemic agency. The epistemic harm of propaganda is that it has the power to alienate its audience from itself both epistemically and politically by illegitimately constraining what is epistemically possible for its audience.
Perceptions About Monetary Policy
Authors: Bauer Michael D , Pflueger Carolin E , Sunderam Adi 
Published: June 2024

Abstract
We estimate perceptions about the Federal Reserve’s monetary policy rule from panel data on professional forecasts of interest rates and macroeconomic conditions. The perceived dependence of the federal funds rate on economic conditions varies substantially over time, in particular over the monetary policy cycle. Forecasters update their perceptions about the Fed’s policy rule in response to monetary policy actions, measured by high-frequency interest rate surprises, suggesting that they have imperfect information about the rule. Monetary policy perceptions matter for monetary transmission, as they affect the sensitivity of interest rates to macroeconomic news, term premia in long-term bonds, and the response of the stock market to monetary policy surprises. A simple learning model with forecaster heterogeneity and incomplete information about the policy rule motivates and explains our empirical findings.
A circadian-informed lighting intervention accelerates circadian adjustment to a night work schedule in a submarine lighting environment
Authors: Guyett Alisha , Lovato Nicole , Manners Jack , Stuart Nicole , Toson Barbara , Lechat Bastien , Lack Leon , Micic Gorica , Banks Siobhan , Dorrian Jillian , Kemps Eva , Vakulin Andrew , Adams Robert , Eckert Danny J , Scott Hannah , Catcheside Peter 
Published: June 2024

Abstract

Study Objective
Night work has detrimental impacts on sleep and performance, primarily due to misalignment between sleep–wake schedules and underlying circadian rhythms. This study tested whether circadian-informed lighting accelerated circadian phase delay, and thus adjustment to night work, compared to blue-depleted standard lighting under simulated submariner work conditions.

Methods
Nineteen healthy sleepers (12 males; mean ± SD aged 29 ± 10 years) participated in two separate 8-day visits approximately 1 month apart to receive, in random order, circadian-informed lighting (blue-enriched and dim, blue-depleted lighting at specific times) and standard lighting (dim, blue-depleted lighting). After an adaptation night (day 1), salivary dim-light melatonin onset (DLMO) assessment was undertaken from 18:00 to 02:00 on days 2–3. During days 3–7, participants completed simulated night work from 00:00 to 08:00 and a sleep period from 10:00 to 19:00. Post-condition DLMO assessment occurred from 21:00 to 13:00 on days 7–8. Ingestible capsules continuously sampled temperature to estimate daily core body temperature minimum (Tmin) time. Tmin and DLMO circadian delays were compared between conditions using mixed effects models.

Results
There were significant condition-by-day interactions in Tmin and DLMO delays (both p &lt; .001). After four simulated night shifts, circadian-informed lighting produced a mean [95% CI] 5.6 [3.0 to 8.2] hours greater delay in Tmin timing and a 4.2 [3.0 to 5.5] hours greater delay in DLMO timing compared to standard lighting.

Conclusions
Circadian-informed lighting accelerates adjustment to shiftwork in a simulated submariner work environment. Circadian lighting interventions warrant consideration in any dimly lit and blue-depleted work environments where circadian adjustment is relevant to help enhance human performance, safety, and health.
Current cell therapies for systemic lupus erythematosus
Authors: Dao Lan T M , Vu Thu Thuy , Nguyen Quyen Thi , Hoang Van T , Nguyen Thanh Liem 
Published: June 2024

Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which multiple organs are damaged by the immune system. Although standard treatment options such as hydroxychloroquine (HCQ), glucocorticoids (GCs), and other immunosuppressive or immune-modulating agents can help to manage symptoms, they do not offer a cure. Hence, there is an urgent need for the development of novel drugs and therapies. In recent decades, cell therapies have been used for the treatment of SLE with encouraging results. Hematopoietic stem cell transplantation, mesenchymal stem cells, regulatory T (Treg) cell, natural killer cells, and chimeric antigen receptor T (CAR T) cells are advanced cell therapies which have been developed and evaluated in clinical trials in humans. In clinical application, each of these approaches has shown advantages and disadvantages. In addition, further studies are necessary to conclusively establish the safety and efficacy of these therapies. This review provides a summary of recent clinical trials investigating cell therapies for SLE treatment, along with a discussion on the potential of other cell-based therapies. The factors influencing the selection of common cell therapies for individual patients are also highlighted.
XIIIThe Victorian Period
Authors: Garza Ana Alicia , Snailham Fiona , Blackburn-Daniels Sally , Baker William 
Published: June 2024

Abstract
The coverage for 2022 has four sections: 1. General and Prose Including Dickens; 2. The Novel; 3. Poetry; 4. Miscellaneous. Section 1 is by Ana Alicia Garza; section 2 is by Fiona Snailham; section 3 is by Sally Blackburn-Daniels; section 4, which is mixed genre, is by William Baker, who thanks for their assistance Dominic Edwards, Brent E. Kinser, Marcus Neacey, and Jean Saunders, The coverage is shorter than usual owing to contributor unreliability; it is hoped that coverage for 2023 publications will include those for 2022 publications not covered here especially in the areas of periodicals and publishing history.
Urea transporter UT‐A1 as a novel drug target for hyponatremia
Authors: Li Nannan , Zhang Hang , Wang Shuyuan , Xu Yue , Ying Yi , Li Jing , Li Xiaowei , Li Min , Yang Baoxue 
Published: June 2024

AbstractHyponatremia is the most common disorder of electrolyte imbalances. It is necessary to develop new type of diuretics to treat hyponatremia without losing electrolytes. Urea transporters (UT) play an important role in the urine concentrating process and have been proved as a novel diuretic target. In this study, rat and mouse syndromes of inappropriate antidiuretic hormone secretion (SIADH) models were constructed and analyzed to determine if UTs are a promising drug target for treating hyponatremia. Experimental results showed that 100 mg/kg UT inhibitor 25a significantly increased serum osmolality (from 249.83 ± 5.95 to 294.33 ± 3.90 mOsm/kg) and serum sodium (from 114 ± 2.07 to 136.67 ± 3.82 mmol/L) respectively in hyponatremia rats by diuresis. Serum chemical examination showed that 25a neither caused another electrolyte imbalance nor influenced the lipid metabolism. Using UT‐A1 and UT‐B knockout mouse SIADH model, it was found that serum osmolality and serum sodium were lowered much less in UT‐A1 knockout mice than in UT‐B knockout mice, which suggest UT‐A1 is a better therapeutic target than UT‐B to treat hyponatremia. This study provides a proof of concept that UT‐A1 is a diuretic target for SIADH‐induced hyponatremia and UT‐A1 inhibitors might be developed into new diuretics to treat hyponatremia.