bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed versus Delayed-Immediate Autologous Breast Reconstruction: A Blinded Evaluation of Aesthetic Outcomes
Authors: Albino Frank P , Patel Ketan M , Smith Jesse R , Nahabedian Maurice Y 
Published: May 2014

Background The technique of delayed-immediate breast reconstruction includes immediate insertion of a tissue expander, post-mastectomy radiation, followed by reconstruction. The aesthetic benefits of delayed-immediate reconstruction compared to delayed reconstruction are postulated but remain unproven. The purpose of this study was to compare aesthetic outcomes in patients following delayed and delayed-immediate autologous breast reconstruction.
Methods A retrospective analysis was performed of all patients who underwent delayed or delayed-immediate autologous breast reconstruction by the senior author from 2005 to 2011. Postoperative photographs were used to evaluate aesthetic outcomes: skin quality, scar formation, superior pole contour, inferior pole contour, and overall aesthetic outcome. Ten non-biased reviewers assessed outcomes using a 5-point Likert scale. Fisher's Exact and Wilcoxon-Mann-Whitney tests were used for comparative analysis.
Results Patient age and body mass index were similar between delayed (n=20) and delayed-immediate (n=20) cohorts (P>0.05). Skin and scar quality was rated significantly higher in the delayed-immediate cohort (3.74 vs. 3.05, P<0.001 and 3.41 vs. 2.79, P<0.001; respectively). Assessment of contour-related parameters, superior pole and inferior pole, found significantly improved outcomes in the delayed-immediate cohort (3.67 vs. 2.96, P<0.001 and 3.84 vs. 3.06, P<0.001; respectively). Delayed-immediate breast reconstruction had a significantly higher overall score compared to delayed breast reconstructions (3.84 vs. 2.94, P<0.001). Smoking and the time interval from radiation to reconstruction were found to affect aesthetic outcomes (P<0.05).
Conclusions Preservation of native mastectomy skin may allow for improved skin/scar quality, breast contour, and overall aesthetic outcomes following a delayed-immediate reconstructive algorithm as compared to delayed breast reconstruction.
Organic Flexible Electronics for Innovative Applications in Electronic Skin
Authors: Liu Xukai , Li Haojie , Tao Minqin , Yu Yingying , Zhu Zijia , Wu Dongdong , Hu Xiaotian , Chen Yiwang 
Published: July 2024

AbstractThe emergence of cutting‐edge cross‐disciplines has motivated the rapid development of wearable technology and flexible electronics. The flexibility and tunable properties of organic materials enable organic flexible electronics to adapt to complex surface deformations and achieve sensitive detection of physiological signals. The cost‐effectiveness of organic materials in mass production offers additional possibilities for the practical and commercialization of e‐skin technology. However, how to ensure stability and long‐term reliability while maintaining a highly sensitive, flexible, and stretchable is a challenge for e‐skins. In this review, the research progress and development trend of e‐skin is systematically summarized, especially the latest breakthroughs and innovations in the frontier of organic flexible electronics, and systematically review the applications of e‐skin in sensors, physiological monitoring, and energy supply. In addition, the review further discusses the prospects and current challenges for the application of organic flexible electronics in e‐skin, which provides a one‐stop reference for the development of e‐skin.
Bionic Microstructure‐Inspired Dual‐Mode Flexible Sensor with Photothermal Effect for Ultrasensitive Temperature and Strain Monitoring
Authors: Guo Xiaohui , Niu Yongzheng , Yin Zhihao , Wang Di , Liu Long , Tang Yongming , Li Xianghui , Zhang Yifang , Li Yu , Zhang Tianxu , Zhu Xiaowen , Xu Yiman , Zhang Ziwen , Ding Siwen , Wang Dandan , Yang Bing , Mai Zhihong , Hong Weiqiang , Xu Wenrui , Hong Qi , Zhao Yunong , Yan Feng , Wang Ming , Xing Guozhong 
Published: July 2024

AbstractFlexible dual‐mode sensors play a pivotal role in information exchange between humans and the environment. However, achieving dual‐mode sensing encompassing both flexibility and stretchability, while accurately quantifying stimulus signals such as temperature, remains a significant challenge. This paper presents a novel flexible dual‐mode strain/temperature sensor (DMSTS) that utilizes graphite powder (GR)/polyaniline (PANI)/silicone rubber composites, inspired by the bionic microstructure of a centipede's foot. The DMSTS exhibits an exceptional strain detection range (≈177%), and a low limit of detection (0.5% strain). Regarding temperature sensing, the DMSTS demonstrates a positive temperature coefficient effect within the range of 25–90 °C, with an ultrahigh sensitivity of 10.3 within the 75–90 °C range. Leveraging the photothermal characteristics of GR and PANI, the DMSTS holds significant promise for applications in human motion detection, infrared imaging, and photothermal effects. When integrated into an intelligent sensing system, it enables dynamic noncontact temperature measurement, human micro‐expression detection, and motion joint monitoring. Additionally, by incorporating a flexible thermochromic film with color‐changing ink, the DMSTS transforms temperature detection into a visually intuitive operation. With its versatile dual‐mode sensing capabilities, the DMSTS exhibits substantial potential in the fields of wearable electronics and healthcare.
Ligand‐Tailored Divergence of Copper‐Catalyzed Aerobic Oxidation of Cyclopropanols. Application to the Practical Synthesis of β‐Aminoketones and β‐Enaminones
Authors: Zavalinich Viktoryia A. , Elek Gábor Zoltán , Vailhé Pauline , Novikau Ilya , Syakhovich Vitaly , Kirillov Alexander M. , Lopp Margus , Masiuk Uladzimir S. , Kananovich Dzmitry G. 
Published: July 2024

AbstractThe aerobic ring‐opening oxidation of cyclopropanols catalyzed by copper complexes was systematically investigated, with a focus on the effect of nitrogen ligands on the distribution of oxidation products. This study led to the development of a new synthesis of β‐aminoketones and β‐enaminones from cyclopropanols, where product specificity is tuned through ligand and solvent selection. β‐Aminoketones were prepared in 34–99% yields by copper(II) acetate‐catalyzed aerobic oxidation of cyclopropanols in the presence of nucleophilic secondary aliphatic amines. In contrast, bipyridine‐ligated copper catalysts resulted in the generation of β‐enaminones in 36–86% yields, presumably via the Kornblum‐DeLaMare rearrangement of intermediate 1,2‐dioxolanes.
The Thermodynamic‐Analysis‐Derived Structure Optimization on the Solar Thermal Localized Desalination and Water‐Treatments
Authors: Huang Yongchao , Li Heyu , Cao Yan 
Published: July 2024

AbstractThe solar thermal localization (STL) technology is promising and cost‐effective for desalination or wastewater treatments, but currently in an insufficient status on its structure optimization. This study emphasized the water‐cooled STL (WSTL) system and its step‐forward modifications, involving the air‐insulated WSTL (AWSTL) system and the vacuum WSTL (VWSTL) system, together with their thermodynamic modeling analysis on energy‐water conversions, heat‐mass transfers, and energy losses. Results indicated the best‐performing VWSTL mode can achieve a freshwater yield as high as 1.503 kg·m−2·h−1 at energy efficiency of 68.0% (the light intensity at 1500 W·m−2 indoor), and that of 4.31 kg·m−2·day−1 at energy efficiency of 47.5% (the 8‐h averaged solar light intensity at 769.7 W·m−2 outdoor per‐day) whose energy efficiency is exceeded all competitors in open literature. There likely is an improvement space in applying better evaporation materials.
Local Electric Field Accelerates Zn2+ Diffusion Kinetics for Zn‐V Battery
Authors: Liu Huibin , Hou Xiaohan , Fan Shiyuan , Cen Mingjun , Chen Zhuo , Chen Bin , Yuan Chen , Peng Wenchao , Li Yang , Fan Xiaobin 
Published: July 2024

AbstractVanadium‐based aqueous zinc‐ion batteries (AZIBs) exhibit significant potential for large‐scale energy storage applications, attributed to their inherent safety characteristics. Addressing the slow transport kinetics of divalent Zn2+ within the cathode lattice, thereby enhancing the rate capability and stability, is essential for the Zn‐V battery system. In this study, a local electric field (LEF) strategy is introduced to accelerate the Zn2+ diffusion by creating abundant oxygen vacancies (Ov) in V2O5. Comprehensive characterization and density functional theory (DFT) calculations reveal the formation of the Ov induced atomic‐level donor‐acceptor couple configuration, verify and visualize the LEF. The fabricated LEF‐enhanced vanadium oxide (LEF‐VO) exhibits exceptional rate capability, achieving 338.3 mA h g−1 at a current density of 10 A g−1, and maintaining 66.4% of its capacity over a range from 0.2 to 20 A g−1. Furthermore, the influence of the LEF on expediting Zn2+ diffusion kinetics is elucidated, correlating to the electrical force. This novel LEF approach offers valuable insights for advancing high‐rate cathode materials.
Chinese consumers' preferences for imported beef products
Authors: Kang Qi , Carpio Carlos E. , Garcia Manuel , Wang Chenggang , Boonsaeng Tullaya , Hudson Darren 
Published: July 2024

AbstractChina's rapidly growing food market offers opportunities for foreign beef producers, thanks to its sizable population and increasing income levels. This study examined Chinese consumers' preferences and willingness to pay (WTP) for credence attributes of beef from the domestic market and other large exporting countries. Three beef cuts were considered: steak, brisket, and tongue. Data were collected from an online survey incorporating choice experiments (CEs) of 2016 consumers from China in 2021. Each respondent was presented with three beef alternatives that differed in price, country of origin, food safety, and production certifications, and also included a “no purchase” option. Chinese consumers' beef selections in the CEs were analyzed using a mixed logit model in WTP space. Results indicate that the type of cut does not influence Chinese consumers' evaluation of country of origin and credence attributes. Moreover, results show that Chinese consumers strongly prefer and are willing to pay more for domestic beef than imported beef. Beef from New Zealand had the highest WTP value among all the exporting countries, followed by Argentina, Australia, Canada, Uruguay, Brazil, and the United States. Also, enhanced food safety, Organic, and Green Food certifications had positive WTP values. The findings of this study offer evidence that Chinese consumers prefer safe and quality‐assured beef products. This information can be used by beef producers targeting the Chinese market to design production and marketing strategies.
Efficient Cu‐Based Mixed Oxides Catalyst for α‐Alkylation of Ketones with Alcohols
Authors: Zhang Lina , Yao Denghong , Wang Xue , Zhang Dong 
Published: July 2024

AbstractA series of Cu‐based mixed oxides were prepared by calcinations of corresponding CuMgAl‐layered double hydroxides precursors at different temperatures with nominal Cu/Mg/Al ratios of 1 : 1 : 2(Cu‐LDH‐1), 1 : 2 : 1(Cu‐LDH‐2),1 : 1 : 1(Cu‐LDH‐3), and 2 : 1 : 1(Cu‐LDH‐4). The synthesized catalysts were characterized using X‐ray diffraction, high‐resolution transmission electron microscopy, scanning electron microscopy, X‐ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, inductively coupled plasma atomic emission spectroscopy (ICP‐AES), and N2 physisorption analysis techniques. All as‐obtained catalysts showed adequate catalytic performance for the α‐alkylation of ketones with alcohols through a hydrogen autotransfer mechanism. The catalyst CuMgAl‐I‐650 (obtained by calcining Cu‐LDH‐1 at 650 °C) displayed the highest activity and selectivity. Using this catalyst system, a wide range of branched ketones were synthesized in good to excellent isolated yields. Moreover, the catalyst CuMgAl‐I‐650 could be recycled and reutilized for four cycles without any significant loss of activity and selectivity. This study provides a very simple and inexpensive catalysis based on transition metals, which are in abundance on earth.
Multimorbidity measures associated with cognitive function among community‐dwelling older Chinese adults
Authors: Wang Shuojia , Chen Yilin , Xiong Lijiao , Jin Nana , Zhao Pengfei , Liang Zhen , Cheng Lixin , Kang Lin 
Published: July 2024

AbstractINTRODUCTIONOlder adults with multimorbidity are at high risk of cognitive impairment development. There is a lack of research on the associations between different multimorbidity measures and cognitive function among older Chinese adults living in the community.METHODSWe used the Chinese Longitudinal Healthy Longevity Survey from 2002 to 2018 and included data on dementia‐free participants aged ≥65 years. Multimorbidity measures included condition counts, multimorbidity patterns, and trajectories. The association of multimorbidity measures with cognitive function was examined by generalized estimating equation and linear and logistic regression models.RESULTSAmong 14,093 participants at baseline, 43.2% had multimorbidity. Multimorbidity patterns were grouped into cancer‐inflammatory, cardiometabolic, and sensory patterns. Multimorbidity trajectories were classified as “onset‐condition,” “newly developing,” and “severe condition.” The Mini‐Mental State Examination scores were significantly lower for participants with more chronic conditions, with cancer‐inflammatory/cardiometabolic/sensory patterns, and with developing multimorbidity trajectories.DISCUSSIONCondition counts, sensory pattern, cardiometabolic pattern, cancer‐inflammatory pattern, and multimorbidity developmental trajectories were prospectively associated with cognitive function.Highlights
Elderly individuals with a higher number of chronic conditions were associated with lower MMSE scores in the Chinese Longitudinal Healthy Longevity Survey data.
MMSE scores were significantly lower for participants with specific multimorbidity patterns.
Individuals with developing trajectories of multimorbidity were associated with lower MMSE scores and a higher risk of mild cognitive impairment.
Primary lateral sclerosis associated with PSEN1 Pro284Leu variant in a Colombian family: Clinical and neuropathological features
Authors: Acosta‐Uribe Juliana , Villegas‐Lanau Andrés , Vallejo Dionis , Ramírez‐Aguilar Laura , Solano Juan M. , Mejía‐Cupajita Bárbara , Aguillón David , Moreno Sonia , Méndez Luis G. , Baena Ana , Madrigal Lucía , Bocanegra Yamile , Quiroz Yakeel T. , García Gloria P. , Vasquez Daniel , Arbeláez Andrés , Lopera Francisco , Beach Thomas G. , Kosik Kenneth S. , White Charles L. , Giraldo‐Chica Margarita 
Published: July 2024

AbstractINTRODUCTIONThis study investigates primary lateral sclerosis (PLS) as a rare manifestation of the presenilin 1 (PSEN1) NM_000021 c.851C > T p.Pro284Leu variant in three siblings of a Colombian family, outlining its clinical and neuropathological features and their relationship to Alzheimer's disease (AD).METHODSData were gathered using clinical evaluations, next‐generation genetic sequencing, magnetic resonance imaging, biomarker analysis, and neuropathological examination.RESULTSCarriers of the PSEN1 Pro284Leu variant exhibited classic PLS symptoms, including unilateral onset and bulbar syndromes, along with cognitive decline. Neuropathology showed corticospinal tract degeneration without amyloid beta deposition in spinal white matter.DISCUSSIONOur findings suggest an overlap between PLS and AD pathology in PSEN1 variant carriers. Results support considering PLS when diagnosing AD‐related motor syndromes and including PSEN1 evaluation when performing genetic testing for PLS. The study highlights the need for further research to clarify the PLS–AD relationship, informing future treatments and clinical trials.Highlights
Pathogenic variants in presenilin 1 (PSEN1) can manifest as hereditary primary lateral sclerosis
PSEN1 Pro284Leu carriers present motor, cognitive, and behavioral alterations
Cases had corticospinal tract microgliosis and severe Aβ pathology in motor cortex
There was no evidence of amyloid deposition in the spinal cord white matter
All the neuropathology images are available for online visualization
Myelin pallor in the spinal cord is confined to the lateral corticospinal tracts
The utility of recruitment incentives in early Alzheimer's disease trials
Authors: Ritchie Marina , Witbracht Megan , Russ Eunji , Sajjadi S. Ahmad , Thai Gaby T. , Tam Steven , Gillen Daniel L. , Grill Joshua D. 
Published: July 2024

AbstractINTRODUCTIONAmid recent approvals, early Alzheimer's disease (AD) remains an active area of treatment development.METHODSWe performed a conjoint experiment to compare preferences among 26 patients with mild cognitive impairment for four trial features including designs incorporating active aducanumab‐control (vs. placebo), returning tau positron emission tomography (PET) results (vs. no disclosure), remote study partner participation (vs. in person), and increased risk of brain swelling (vs. lower risk). We used a generalized estimating equation to model the utility of factor levels.RESULTSReturning tau PET results had the highest utility (est: 0.47; 95% confidence interval [CI]: 0.13, 0.81; P = 0.007); remote study partner participation showed a similar trend (est: 0.29; 95% CI: −0.05, 0.63; P = 0.097). Trials with active‐controlled design (est: 0.01; 95% CI: −0.33, 0.35; P = 0.956) did not demonstrate utility and higher risk of brain swelling had negative utility (est: −0.64; 95% CI: −0.99, −0.30; P < 0.001).DISCUSSIONReturning additional biomarker results may increase willingness to enroll in early AD trials.Highlights
We compared mild cognitive impairment participant preferences for four trial design features.
Returning tau positron emission tomography results had the highest utility.
Remote study partner participation showed a positive, albeit non‐significant, trend.
No utility was observed for an active aducanumab‐control design.
Strengthening an Intramolecular Non‐Classical Hydrogen Bond to Get in Shape for Binding
Authors: Varga Norbert , Smieško Martin , Jiang Xiaohua , Jakob Roman P. , Wagner Beatrice , Mühlethaler Tobias , Dätwyler Philipp , Zihlmann Pascal , Rabbani Said , Maier Timm , Schwardt Oliver , Ernst Beat 
Published: July 2024

AbstractIn this research article, we report on the strengthening of a non‐classical hydrogen bond (C−H⋅⋅⋅O) by introducing electron withdrawing groups at the carbon atom. The approach is demonstrated on the example of derivatives of the physiological E‐selectin ligand sialyl Lewisx (1, sLex). Its affinity is mainly due to a beneficial entropy term, which is predominantly caused by the pre‐organization of sLex in its binding conformation. We have shown, that among the elements responsible for the pre‐organization, the stabilization by a non‐classical hydrogen bond between the H−C5 of l‐fucose and the ring oxygen O5 of the neighboring d‐galactose moiety is essential and yields 7.4 kJ mol−1. This effect could be further strengthened by replacing l‐fucose by 6,6,6‐trifluoro‐l‐fucose leading to an improved non‐classical H‐bond of 14.9 kJ mol−1, i.e., an improved pre‐organization in the bioactive conformation. For a series of glycomimetics of sLex (1), this outcome could be confirmed by high field NMR‐shifts of the H−C5Fuc, by X‐ray diffraction analysis of glycomimetics co‐crystallized with E‐selectin as well as by isothermal titration calorimetry. Furthermore, the electron‐withdrawing character of the CF3‐group beneficially influences the pharmacokinetic properties of sLex mimetics. Thus, acid‐stability, a prerequisite for gastrointestinal stability, could be substantially improved.
Photocatalytic Direct Para‐Selective C−H Amination of Benzyl Alcohols: Selectivity Independent of Side Substituents
Authors: Liu Donghan , Tu Ting , Zhang Tinglei , Nie Guihua , Liao Tianhui , Ren Shi‐Chao , Zhang Xinglong , Chi Yonggui Robin 
Published: July 2024

AbstractAminoarenes are important molecules for broad applications in nearly all modern industries that involve chemicals. Direct and site‐selective C−H bond amination of arenes provides the most efficient and convenient method to prepare aminoarenes. A main challenge is to selectively install the amino group (or other functional groups) to the distal para‐carbon of arenes (especially multi‐substituted arenes) during the C−H bond functionalization events. Herein, we address this problem by designing a new strategy via a sequential radical dearomatization/radical amination/rearomatization process for para‐selective amination of benzyl alcohols. The para‐selectivity of our reaction is completely independent of the electronic and steric properties of the other substituents of the arene substrates. Aminoarenes with many substituents (up to full substitution) and diverse substitution patterns, including those difficult to synthesize previously, could be readily prepared using our protocols. Further exploration of the current strategy shall lead to other challenging C−H functionalization of arenes.
Matched Electron‐Transport Materials Enabling Efficient and Stable Perovskite Quantum‐Dot‐Based Light‐Emitting Diodes
Authors: Wang Jindi , Li Mingyang , Cai Bo , Ren Hongdan , Fan Wenxuan , Xu Leimeng , Yao Jisong , Wang Shalong , Song Jizhong 
Published: July 2024

AbstractLight‐emitting diodes (LEDs) based on perovskite quantum dots (QDs), abbreviated as P‐QLEDs have been regarded as significantly crucial emitters for lighting and displays. Efficient and stable P‐QLEDs still lack ideal electron transport materials (ETM), which could efficiently block hole, transport electron, reduce interface non‐radiative recombination and possess high thermal stability. Here, we report 2,4,6‐Tris(3′‐(pyridine‐3‐yl) biphenyl‐3‐yl)‐1,3,5‐triazine (TmPPPyTz, 3P) with strong electron‐withdrawing moieties of pyridine and triazine to modulate the performance of P‐QLEDs. Compared with commonly used 1,3,5‐Tris(1‐phenyl‐1H‐benzimidazol‐2‐yl)benzene (TPBi), the pyridine in 3P have a strong interaction with perovskites, which can effectively suppress the interface non‐radiative recombination caused by the Pb2+ defects on the surface of QDs. In addition, 3P have deep highest occupied molecular orbital (HOMO) (enhancing hole‐blocking properties), matched lowest unoccupied molecular orbital (LUMO) and excellent electron mobility (enhancing electron transport properties), realizing the carrier balance and maximizing the exciton recombination. Furthermore, high thermal resistance of 3P obviously improves the stability of QDs under variable temperature, continuous UV illumination, and electric field excitation. Resultantly, the P‐QLEDs using the 3P as ETM achieved an outstanding performance with a champion EQE of 30.2 % and an operational lifetime T50 of 3220 hours at an initial luminance of 100 cd m−2, which is 151 % and about 11‐fold improvement compared to control devices (EQE=20 %, T50=297 hours), respectively. These results provide a new concept for constructing the efficient and stable P‐QLEDs from the perspective of selective ETM.