bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive member adding for truss topology optimization: application to elastic design
Authors: Fairclough Helen E. 
Published: July 2024

AbstractThis paper provides a rigorous and computationally efficient means of identifying compliance-based optimal truss topologies from high-resolution ground structures—problems involving over 30 million potential elements can be solved in under 1 h on a typical laptop. The adaptive ‘member adding’ approach is shown to provide significant savings in computational time and memory usage compared to directly solving the full optimization problem, whilst obtaining the same optimal solution; this paper presents the first application of this powerful principle to the well-known linear-elastic design problem. The computational advantages are particularly notable for multiple load-case problems, as the numerical structure of these cannot be effectively exploited without understanding of the physical nature of the problem. For such cases, the member adding process reduces the computational time required from approximately $$O(m^2)$$

O
(

m
2

)

to O(m), where m is the number of potential elements; here, the time required is reduced by a factor of up to 60 for the relatively small problems that could be solved with both approaches. By using the member adding approach, compliance-optimized structures are obtained at a significantly higher resolution than has previously been possible. The findings of this paper have the potential to deliver a step change in the size of problems that can be solved in compliance-based truss topology optimization, and an accompanying Python code is provided to facilitate this.
Nugget and corona bond size measurement through active thermography and transfer learning model
Authors: Santoro Luca , Razza Valentino , De Maddis Manuela 
Published: July 2024

AbstractResistance spot welding (RSW) is considered a preferred technique for joining metal parts in various industries, mainly for its efficiency and cost-effectiveness. The mechanical properties of spot welds are pivotal in ensuring structural integrity and overall assembly performance. In this work, the quality attributes of resistance spot welding, such as both nugget and corona bond sizes, are assessed by analyzing the thermal behavior of the joint using a physical information neural network (PINN). Starting from the thermal signal phase gradient and amplitude gradient maps, a convolutional neural network (CNN) estimates the size of nuggets and corona bonds. The CNN architecture is based on the Inception V3 architecture, a state-of-the-art neural network that excels in image recognition tasks. This study suggests adopting a new methodology for automatic RSW quality control based on thermal signal analysis.
Incidence of and Risk Factors for Post-Operative Urinary Retention Following Surgery for Perineal Tears Among Ugandan Women: A Prospective Cohort Study
Authors: Kayondo Musa , Byamukama Onesmus , Ainomugisha Brenda , Kajabwangu Rogers , Kalyebara Paul Kato , Tibaijuka Leevan , Lugobe Henry Mark , Geissbühler Verena 
Published: July 2024

Abstract
Introduction and Hypothesis
We aimed to determine the incidence and risk factors for post-operative urinary retention (POUR) following surgery for perineal tears, and to determine the time to normal voiding after POUR.

Methods
This was a prospective cohort study of women who underwent surgery for old (≥ 3 months) obstetric perineal tears from January 2022 to December 2023. The diagnosis of POUR was made in a woman who completely failed to void despite a full bladder or, one who had post-void residual (PVR) > 150 ml within 10 min of voiding. Return to normal voiding was considered if a patient with POUR had two consecutive PVRs of ≤ 150 ml. Descriptive analyses and multivariable logistic regression were performed to determine risk factors for POUR.

Results
A total of 153 participants were enrolled in this study with a mean age of 35.9 (SD ± 10.8) years. The incidence of POUR was 19.6% (30/153, 95% CI 14.02–26.7), and the median time to normal voiding for these patients was 42.4 h (range 24–72). Risk factors for POUR included repeat perineal tear surgery (RR = 4.24; 95% CI 1.16–15.52; p = 0.029) and early urinary catheter removal (RR = 2.89; 95% CI 1.09–7.67; p = 0.033).

Conclusion
Post-operative urinary retention following surgery for perineal tears is common. The time to return to normal voiding in patients with POUR is short. Women having repeat perineal tear surgery and those in whom the urinary catheter is removed early were more likely to experience POUR. Delayed urinary catheter removal could be considered, especially in patients undergoing repeat perineal tear surgery.
A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease
Authors: Abobakr Shimaa , Shaker Olfat , Hegazy Mohamed Tharwat , Hany Ayman Mohamed 
Published: July 2024

AbstractBehcet’s disease (BD) is a multisystem disease with altered Toll-like receptors (TLRs) on macrophages. Long noncoding RNA Maternally expressed gene 3 (lncRNA MEG3) and lncRNA Musculoaponeurotic fibrosarcoma oncogene family, protein G antisense 1 (MAFG-AS1) are regulators of microRNA (miRNA) 147-b, which is induced upon TLR stimulation. We included fifty BD patients, and fifty age and sex-matched controls. Real-time polymerase chain reaction (PCR) was used to measure the expression levels of serum lncRNA MEG3, lncRNA MAFG-AS1, and miRNA 147-b. LncRNA MEG3 and lncRNA MAFG-AS1 were significantly downregulated while miRNA 147-b was significantly upregulated in the BD patients' serum compared to the controls with p-value <0.001. Receiver operation characteristics (ROC) curve analysis revealed that the three biomarkers can discriminate between BD and control subjects with 76%, 100%, and 70% sensitivity respectively, and 100% specificity for all of them. There was a lower expression level of lnc RNA MEG3 among patients who had new eye involvement in the last month in comparison to those without new eye involvement (p-value=0.017). So, LncRNA MEG3, lncRNA MAFG-AS1, and miRNA147-b are promising diagnostic markers and therapeutic targets for BD patients. LncRNA MEG3 can be used as a predictor for new BD ocular involvement.
A new standardization for the use of chicken embryo: selection of target from the phage display library and infection
Authors: de Souza Jessica Brito , Sommerfeld Simone , Almeida-Souza Hebréia Oliveira , Vaz Emília Rezende , Bastos Luciana Machado , Santos Fabiana de Almeida Araújo , Rodrigues Alessandra Castro , Medeiros-Ronchi Alessandra Aparecida , Goulart Luiz Ricardo , Fonseca Belchiolina Beatriz 
Published: July 2024

Abstract
The filamentous bacteriophage M13KO7 (M13) is the most used in phage display (PD) technology and, like other phages, has been applied in several areas of medicine, agriculture, and in the food industry. One of the advantages is that they can modulate the immune response in the presence of pathogenic microorganisms, such as bacteria and viruses. This study evaluated the use of phage M13 in the chicken embryos model. We inoculated 13-day-old chicken embryos with Salmonella Pullorum (SP) and then evaluated survival for the presence of phage M13 or E. coli ER2738 (ECR) infected with M13. We found that the ECR bacterium inhibits SP multiplication in 0.32 (M13-infected ECR) or 0.44 log UFC/mL (M13-uninfected ECR) and that the ECR-free phage M13 from the PD library can be used in chicken embryo models. This work provides the use of the chicken embryo as a model to study systemic infection and can be employed as an analysis tool for various peptides that M13 can express from PD selection.

Key points
• SP-infected chicken embryo can be a helpful model of systemic infection for different tests.
• Phage M13 does not lead to embryonic mortality or cause serious injury to embryos.
• Phage M13 from the PD library can be used in chicken embryo model tests.
Regorafenib plus FOLFIRINOX as first-line treatment for patients with RAS-mutant metastatic colorectal cancer (FOLFIRINOX-R trial): a dose-escalation study
Authors: Adenis Antoine , Ghiringhelli François , Gauthier Ludovic , Mazard Thibault , Evesque Ludovic , Evrard Alexandre , Chalbos Patrick , Moussion Aurore , Gourgou Sophie , Ychou Marc 
Published: July 2024

Abstract
Purpose
The combination of bevacizumab and FOLFIRINOX is used in patients with RAS-mutant metastatic colorectal cancer (RASm-mCRC). Regorafenib, an oral multi-tyrosine kinase inhibitor, has antiangiogenic properties, cytostatic effects and also true cytotoxic effects, unlike bevacizumab. The aim of this study was to determine the maximum tolerated dose (MTD) and the recommended phase 2 dose (RP2D) of the regorafenib-FOLFIRINOX combination in patients with RASm-mCRC.

Methods
The FOLFIRINOX-R trial was a phase 1/2 study where the dose-escalation part (3 + 3 design with three dose levels, DLs) was completed before its early termination. FOLFIRINOX (14-day cycle) included oxaliplatin (standard dose), folinic acid, fluorouracil and irinotecan (150 or 180 mg/m²). Regorafenib (120 or 160 mg daily) was given from day 4 to day 10 of each cycle. Dose-limiting toxicity (DLT) was studied in the first three cycles. Eligibility criteria included ECOG performance status ≤ 1 and not previously treated RASm-mCRC.

Results
Thirteen patients (median age: 65 years; min-max: 40–76) were enrolled. DLT could not be evaluated in one patient (DL3) due to poor observance. The median treatment duration and median follow-up were 6.2 (min-max: 2.3–10) and 13.4 (min-max: 3.8–18.0) months, respectively. Dose was modified in 12/13 (92%) patients. One grade 3 hypokalemia occurred at DL2. MTD was not reached at DL3. Grade 3 diarrhea was recorded in 7/13 patients (13 events) equally distributed in all DLs.

Conclusion
The RP2D for this regorafenib-FFX combination could not be determined due to a high prevalence of grade 3 diarrhea related to treatment as advised by our Independent Data Monitoring Committee.

Trial registration numbers
ClinicalTrials.gov: NCT03828799.
ProsTAV, a clinically useful test in prostate cancer: an extension study
Authors: Gómez-Gómez Enrique , Martínez-Salamanca Juan Ignacio , Bianco Fernando , Miles Brian J , Burgos Javier , Quintas Juan Justo , Cano-Castiñeira Roque , Gómez-Ferrer Álvaro , Rodríguez-Antolín Alfredo , Chéchile Gilberto , Fernández Luis , Martín Almudena , Hidalgo Paloma , Parramón Mónica 
Published: July 2024

Abstract
Purpose
To assess the clinical performance of ProsTAV®, a blood-based test based on telomere associate variables (TAV) measurement, to support biopsy decision-making when diagnosing suspicious prostate cancer (PCa).

Methods
Preliminary data of a prospective observational pragmatic study of patients with prostate-specific antigen (PSA) levels 3–10 ng/ml and suspicious PCa. Results were combined with other clinical data, and all patients underwent prostate biopsies according to each center’s routine clinical practice, while magnetic resonance imaging (MRI) before the prostate biopsy was optional. Sensitivity, specificity, positive and negative predicted values, and subjects where biopsies could have been avoided using ProsTAV were determined.

Results
The mean age of the participants (n = 251) was 67.4 years, with a mean PSA of 5.90 ng/ml, a mean free PSA of 18.9%, and a PSA density of 0.14 ng/ml. Digital rectal examination was abnormal in 21.1% of the subjects, and according to biopsy, the prevalence of significant PCa was 47.8%. The area under the ROC curve of ProsTAV was 0.7, with a sensitivity of 0.90 (95% CI, 0.85–0.95) and specificity of 0.27 (95% CI, 0.19–0.34). The positive and negative predictive values were 0.53 (95% CI, 0.46–0.60) and 0.74 (95% CI, 0.62–0.87), respectively. ProsTAV could have reduced the biopsies performed by 27% and showed some initial evidence of a putative benefit in the diagnosis pathway combined with MRI.

Conclusions
ProsTAV increases the prediction capacity of significant PCa in patients with PSA between 3 and 10 ng/ml and could be considered a complementary tool to improve the patient diagnosis pathway.
Strong s-box construction approach based on Josephus problem
Authors: Artuğer Fırat 
Published: July 2024

AbstractThere are two basic requirements for symmetric encryption algorithms. The first of these is diffusion. The second and most important is confusion. In these algorithms, this requirement is usually met by s-box structures. Therefore, s-box structures must be strong. So, a cryptographically good s-box will make the encryption algorithm difficult to crack. However, obtaining a strong s-box is a rather difficult problem. In this study, Josephus circle logic is used to solve this problem. Initially, with a random s-box structure, the elements are replaced according to their Josephus positions, and the s-box is made stronger. In the proposed algorithm, according to the Josephus logic, the elements that kill each other are replaced and this process continues until one element remains. The last 30 surviving elements are replaced with all elements. In this way, three different s-boxes were obtained. In two of them, the nonlinearity value was 110.5, and in one of them, the nonlinearity value was 110.75. Fixed points in the proposed s-box structures were identified and eliminated. In addition, it has been proven because of the analysis that the obtained s-box structures also meet other cryptographic requirements. In addition to leaving behind most studies in the literature, the proposed method will also provide strong s-box structures for encryption algorithms to be built in the future.
Communication patterns in families affected by parental cancer from the healthy parents’ perspective—process evaluation of the complex intervention Family-SCOUT
Authors: Heier L. , Weiß J. , Heuser C. , Nakata H. , Brock-Midding E. , Horbach-Bremen R. , Brümmendorf T. H. , Brüne M. , Dohmen M. , Drueke B. , Geiser F. , Holsteg S. , Icks A. , Karger A. , Panse J. , Petermann-Meyer A. , Viehmann A. , Ernstmann N. 
Published: July 2024

Abstract
Purpose
Within families affected by parental cancer, open communication impacts the well-being of parents and their children; however, limited research exists on communication patterns in these families. This sub-study addresses this through the Family-SCOUT study, a multicenter, prospective, interventional, and non-randomized investigation with intervention (IG) and control group (CG). The purpose of this sub-study was to identify and compare the differences in communication patterns between the IG and CG as part of the process evaluation. The research question was addressed in both groups: What communication patterns do healthy parents perceive within their families?

Methods
Using a qualitative approach, the study involved interviewing healthy parents as surrogates for their families. The interviews were audio-recorded, transcribed, and coded using a template analysis. The resulting data were analyzed at the group level.

Results
Twenty-three interviews were conducted in the IG and 27 interviews in the CG. The analysis of themes centered on communication patterns as seen in the family structure. Both groups exhibited instances of open communication about fears and wishes as well as the use of child-friendly language when discussing cancer. Notable differences were observed: challenges in open communication with children were sorely reported in CG interviews, and “the illness is discussed when necessary” was sorely described in IG interviews.

Conclusion
This study underscores the need to address and encourage open communication within families with parental cancer.
Breaking the silence: the role of sexual communication on quality of life in women with cervical cancer
Authors: Liberacka-Dwojak Magdalena , Wiłkość-Dębczyńska Monika , Perkowski Radosław 
Published: July 2024

Abstract
Introduction
Cervical cancer (CC) and its treatments impact various dimensions of quality of life (QoL), including physical, psychological, and sexual functioning. Sexual health, a crucial QoL aspect, is often compromised, highlighting the necessity for open sexual communication.

Materials and methods
This study involved 60 women diagnosed with stage IIb-IIIa CC. The 36-Item Short Form Survey (SF-36) was used to measure physical and psychological components of QoL, the Female Sexual Function Index-6 (FSFI-6) to assess its sexual component, and the Sexual Communication Self-Efficacy Scale (SCSES) to diagnose communication confidence. Self-administered questions gauged patient-provider sexual communication. The results include quotes from participants, providing additional insight.

Results
Sexual communication self-efficacy and patient-provider communication correlated significantly with QoL components. Only 23.33% discussed sexual issues with their doctors. Participants’ experiences highlighted the impact of cancer on sexuality and the need for tailored support.

Discussion
Post-diagnosis psychosexual changes emphasize the importance of communication in renegotiating sexual identity and needs. Effective communication is associated with improved QoL, highlighting the role of healthcare professionals in addressing psychosexual issues. Integrating PLISSIT and BETTER models provides a comprehensive approach to sexual communication in the cancer context.

Conclusion
The study demonstrates the importance of sexual communication self-efficacy in QoL of CC patients and highlights the need for healthcare professionals to include sexual communication education in cancer care.
On the Neumann (p, q)-eigenvalue problem in Hölder singular domains
Authors: Garain Prashanta , Pchelintsev Valerii , Ukhlov Alexander 
Published: July 2024

AbstractIn the article we study the Neumann (p, q)-eigenvalue problems in bounded Hölder $$\gamma $$
γ
-singular domains $$\Omega _{\gamma }\subset {\mathbb {R}}^n$$

Ω
γ

⊂

R

n

. In the case $$1<p<\infty $$

1
<
p
<
∞

and $$1<q<p^{*}_{\gamma }$$

1
<
q
<

p
γ

∗

we prove solvability of this eigenvalue problem and existence of the minimizer of the associated variational problem. In addition, we establish some regularity results of the eigenfunctions and some estimates of (p, q)-eigenvalues.
The majority of patients report satisfaction more than 24 years after temporomandibular joint discectomy
Authors: Bäckström Esmeralda , Wänman Anders , Sjöström Mats 
Published: July 2024

Abstract
Purpose
To retrospectively evaluate long-term outcomes after temporomandibular joint (TMJ) discectomy.

Methods
Included patients (n = 64) had undergone discectomy during 1989-1998 at Umeå University Hospital. A questionnaire was used to evaluate pre- and postoperative symptoms, postoperative complications, general pain, and subjective opinion about the outcome of the surgery.

Results
The results are based on responses from 47 patients (40 women/7 men), including 36 (30 women/6 men) who completed the questionnaire and 11 (10 women/1 man) who were contacted by telephone and answered selected questions. Seventeen patients were excluded because of death, a move abroad, declining to participate, or no available patient information. Among the respondents, 41 (87%) were satisfied with the results, five (11%) were unsatisfied, and one (2%) patient did not answer the question. The results showed a significant long-term improvement in locking, clicking/crepitation, and pain when chewing or opening the jaw (p = 0.001). The prevalence of headaches had decreased significantly at follow-up (p = 0.001). Reported impaired jaw-opening capacity showed no significant improvement (p = 0.08). Of the 47 respondents, 19 (40%) had asked for additional treatment after the discectomy, and six of the 19 patients (13%) had undergone more surgery of the joint.

Conclusion
The results of this retrospective long-term follow-up study indicate that TMJ discectomy has a high success rate, as most patients were satisfied with the postoperative results. Discectomy is thus an effective surgical intervention for patients with disabling TMJ pain and dysfunction when conservative interventions have been unsuccessful.
Intersecting realms: a cross-disciplinary examination of VR quality of experience research
Authors: Zheleva Aleksandra , De Marez Lieven , Talsma Durk , Bombeke Klaas 
Published: July 2024

AbstractThe advent of virtual reality (VR) technology has necessitated a reevaluation of quality of experience (QoE) models. While numerous recent efforts have been dedicated to creating comprehensive QoE frameworks it seems that the majority of the factors studied as potential influencers of QoE are often limited to single disciplinary viewpoints or specific user-related aspects. Furthermore, the majority of literature reviews in this domain seem to have predominantly focused on academic sources, overlooking industry insights. To address these points, the current research took an interdisciplinary literature review approach to examine QoE literature covering both academic and industry sources from diverse fields (i.e., psychology, ergonomics, user experience, communication science, and engineering). Based on this rich dataset, we created a QoE model that illustrated 252 factors grouped into four branches - user, system, context, and content. The main finding of this review emphasized the substantial gap in the current research landscape, where complex interactions among user, system, context, and content factors in VR are overlooked. The current research not only identified this crucial disparity in existing QoE studies but also provided a substantial online repository of over 200 QoE-related factors. The repository serves as an indispensable tool for future researchers aiming to construct a more holistic understanding of QoE.