bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memantine may affect pseudobulbar affect in patients with Alzheimer's disease
Authors: Prokšelj Tatjana , Jerin Aleš , Kogoj Aleš 
Published: April 2013

ObjectiveBehavioural symptoms are common in moderate to severe Alzheimer's disease (AD) and are improved by memantine with the most pronounced effect on agitation/aggression. Dextromethorphan in combination with quinidine is the only drug approved by US Food and Drug Administration for the treatment of pseudobulbar affect (PBA) on the basis of efficacy in patients with multiple sclerosis or amyotrophic lateral sclerosis. The aim of our study was to evaluate the efficacy of memantine on PBA in patients with AD.MethodsIn a prospective, double-blind, case-control study to assess PBA with pathological laughter and crying scale patients were administered memantine (final dose of 20 mg daily) or citalopram (20 mg once daily), each for 10 weeks. The number of episodes of involuntary emotional expression, Neuropsychiatric Inventory (NPI) and Overt Aggression Scale-Modified (OAS-M) total scores were also recorded. Furthermore, the platelet serotonin (5-HT) concentration was measured.ResultsAlthough memantine had beneficial effects on PBA, it also had a crucial impact on behavioural symptoms, especially aggression and agitation (to an average of 3.5 times higher end-point scores on OAS-M and increase of NPI total scores for an average of 114% of initial value). Therefore, the study was prematurely stopped. In addition, we had evidenced a drop of platelet 5-HT concentration (to an average of 73% of initial value).ConclusionSurprisingly, our research showed the opposite action of memantine on neuropsychiatric symptoms as expected. In a limited number of AD patients with PBA, memantine had a beneficial effect on involuntary emotional expression, but it potentiated agitation/aggression, irritability and caused a crucial drop of the platelet 5-HT concentration.
THE EMERGENCE OF A NOVEL ONOMASTIC PATTERN:COGNOMEN + NOMENIN SENECA THE ELDER
Authors: Echavarren Arturo 
Published: April 2013

The formulacognomen + nomen, as portrayed inLatronis enim Porcii(Sen.Controv. 1praef. 13), the first double-name reference withoutpraenomenin Seneca the Elder's work (henceforth referred to simply as Seneca), emerged as a result of the radical changes which the Roman onomastic system began to experience at the end of the Republic. On account of a wide variety of factors, both social and linguistic, thecognomenseized the role of diacritic name and individual signifier, having oustedpraenomenfrom its ancient throne; the relatively limited number ofpraenominain common use contributed substantially to their waning. The formulae of two constituents visibly reflected the progressive decline ofpraenomina; during the Early Principate double names still represented the usual formal means of reference (tria nominabeing highly formal, mostly occurring in official contexts), but it mostly consisted ofnomen + cognomenrather thanpraenomen + nomenorpraenomen + cognomen. The formulanomen + cognomen, which developed once personalcognominabegan to spread among the lesser classes, was primarily crafted for addressing men of ambiguous status,peregriniand freedmen. Thus, Cicero tends to avoid its use in naming members of the nobility, whom he refers to with a clear preference for the older, lustrous conjunctionpraenomen + cognomen.
WHO SINGS THE HOOPOE'S SONG? ARISTOPHANES,BIRDS202–8
Authors: Liapis Vayos J. 
Published: April 2013

At Aristophanes,Birds172ff., Peisetaerus persuades the Hoopoe that the birds would be better off building a city in the clouds. The Hoopoe announces that he will go off to summon the other birds to an assembly, so that the proposal may be approved. ‘How will you summon them?’, asks Peisetaerus. ‘That's easy’, replies the Hoopoe:ΕΠΟΨδɛυρὶ γὰρ ἐμβὰς αὐτίκα μάλ' ɛἰς τὴν λόχμην,ἔπɛιτ' ἀνɛγɛίρας τὴν ἐμὴν ἀηδόνα,καλοῦμɛν αὐτούς· οἱ δὲ νῷν τοῦ ϕθέγματοςἐάνπɛρ ἐπακούσωσι θɛύσονται δρόμῳ. 205ΠΕΙΣΕΤΑΙΡΟΣὦ ϕίλτατ' ὀρνίθων σύ, μή νυν ἕσταθι·ἀλλ', ἀντιβολῶ σ', ἄγ' ὡς τάχιστ' ɛἰς τὴν λόχμηνɛἴσβαινɛ κἀνέγɛιρɛ τὴν ἀηδόνα.
ILIAD24 AND THE JUDGEMENT OF PARIS
Authors: Mackie C.J. 
Published: April 2013

Despite the importance of the Judgement of Paris in the story of the Trojan War, theIliadhas only one explicit reference to it. This occurs, rather out of the blue, in the final book of the poem in a dispute among the gods about the treatment of Hector's body (24.25–30). Achilles keeps dragging the body around behind his chariot, but Apollo protects it with his golden aegis (24.18–21). Apollo then speaks among the gods and attacks the conduct of Achilles (24.33–54), claiming at the end that he offends the dumb earth (24.54). Other gods too have their concerns about what is going on, and they keep trying to get Hermes to snatch the body away (24.23–4). The three most powerful divine enemies of Troy, however, Hera, Poseidon and Athena, will have none of this. They remain as hostile to Troy and Priam and his people as they ever were, and it is in this context that the Judgement of Paris is mentioned:ἔνθ' ἄλλοις μὲν πᾶσιν ἑήνδανɛν, οὐδέ πoθ' Ἥρῃοὐδὲ Ποσɛιδάων' οὐδὲ γλαυκώπιδι κούρῃ,ἀλλ' ἔχον ὥς σϕιν πρῶτον ἀπήχθɛτο Ἴλιος ἱρὴκαὶ Πρίαμος καὶ λαὸς Ἀλɛξάνδρου ἕνɛκ' ἄτης,ὃς νɛίκɛσσɛ θɛάς, ὅτɛ οἱ μέσσαυλον ἵκοντο,τὴν δ' ᾔνησ' ἥ οἱ πόρɛ μαχλοσύνην ἀλɛγɛινήν.(24.25–30)And this was pleasing to all the others, but never to Heranor to Poseidon, nor to the flashing-eyed maiden,but they remained hostile to sacred Ilios as in the beginning,and to Priam and to his people, because of Alexander's folly,he who insulted the goddesses when they came to his inner courtyardand praised her who provided his grievous lust.
CICERO'SSILVA(A NOTE ONAD ATTICUM12.15)
Authors: Walters Brian 
Published: April 2013

In mid-February 45b.c.e., in a tragedy that was to plunge the orator into seemingly irreparable despair, Cicero's beloved daughter Tullia died. She had given birth nearly a month before and at first seemed to be doing well. Soon, however, her health gave out and Cicero took her to his Tusculan villa to recover. In the end, there was little that could be done. After her funeral, Cicero stayed for about three weeks with Atticus in Rome, but the constant stream of visitors offering condolences became too much to bear, and on the sixth of March the heartbroken father retired to a villa he owned on the coast at Astura, some 45 miles south of Rome. Three days later he dispatched the following anguished epistle (Att. 12.15):Apud Appuleium, quoniam in perpetuum non placet, in dies ut excuser videbis. in hac solitudine careo omnium colloquio, cumque mane me in silvam abstrusi densam et asperam, non exeo inde ante vesperum. secundum te nihil est mihi amicius solitudine. in ea mihi omnis sermo est cum litteris. eum tamen interpellat fletus; cui repugno quoad possum, sed adhuc pares non sumus. Bruto, ut suades, rescribam. eas litteras cras habebis. cum erit cui des, dabis.
VIRGIL'S LIME-WOOD YOKE (GEORGICS1.173–4)
Authors: Cairns Francis 
Published: April 2013

caeditur et tilia ante iugo leuis altaque fagusstiuaque, quae currus a tergo torqueat imosIn these two lines of his instructions for making a plough Virgil prescribes (173) the wood of thetilia(lime) as suitable for theiugum(yoke); he also (173–4) mentions thefagus(beech), seemingly in connection with the making of thestiua(stilt/handle). These recommendations are both problematic, and since the latter admits of no sure solution, treatment of it is relegated to a brief Appendix (below). The body of this paper has two aims: 1) to propose a new understanding of Virgil's prescription of thetiliafor theiugum; and 2) to draw attention to Virgil's use of the Hesiod scholia in his plough instructions.
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis
Authors: TATE EDWARD W. , BELL ANDREW S. , RACKHAM MARK D. , WRIGHT MEGAN H. 
Published: April 2013

SUMMARYInfections caused by protozoan parasites are among the most widespread and intractable transmissible diseases affecting the developing world, with malaria and leishmaniasis being the most costly in terms of morbidity and mortality. Although new drugs are urgently required against both diseases in the face of ever-rising resistance to frontline therapies, very few candidates passing through development pipelines possess a known and novel mode of action. Set in the context of drugs currently in use and under development, we present the evidence forN-myristoyltransferase (NMT), an enzyme thatN-terminally lipidates a wide range of specific target proteins through post-translational modification, as a potential drug target in malaria and the leishmaniases. We discuss the limitations of current knowledge regarding the downstream targets of this enzyme in protozoa, and our recent progress towards potent cell-active NMT inhibitors against the most clinically-relevant species of parasite. Finally, we outline the next steps required in terms of both tools to understandN-myristoylation in protozoan parasites, and the generation of potential development candidates based on the output of our recently-reported high-throughput screens.
The 5% difference: early sensory processing predicts sarcasm perception in schizophrenia and schizo-affective disorder
Authors: Kantrowitz J. T. , Hoptman M. J. , Leitman D. I. , Silipo G. , Javitt D. C. 
Published: April 2013

BackgroundIntact sarcasm perception is a crucial component of social cognition and mentalizing (the ability to understand the mental state of oneself and others). In sarcasm, tone of voice is used to negate the literal meaning of an utterance. In particular, changes in pitch are used to distinguish between sincere and sarcastic utterances. Schizophrenia patients show well-replicated deficits in auditory function and functional connectivity (FC) within and between auditory cortical regions. In this study we investigated the contributions of auditory deficits to sarcasm perception in schizophrenia.MethodAuditory measures including pitch processing, auditory emotion recognition (AER) and sarcasm detection were obtained from 76 patients with schizophrenia/schizo-affective disorder and 72 controls. Resting-state FC (rsFC) was obtained from a subsample and was analyzed using seeds placed in both auditory cortex and meta-analysis-defined core-mentalizing regions relative to auditory performance.ResultsPatients showed large effect-size deficits across auditory measures. Sarcasm deficits correlated significantly with general functioning and impaired pitch processing both across groups and within the patient group alone. Patients also showed reduced sensitivity to alterations in mean pitch and variability. For patients, sarcasm discrimination correlated exclusively with the level of rsFC within primary auditory regions whereas for controls, correlations were observed exclusively within core-mentalizing regions (the right posterior superior temporal gyrus, anterior superior temporal sulcus and insula, and left posterior medial temporal gyrus).ConclusionsThese findings confirm the contribution of auditory deficits to theory of mind (ToM) impairments in schizophrenia, and demonstrate that FC within auditory, but not core-mentalizing, regions is rate limiting with respect to sarcasm detection in schizophrenia.
Attributing sporadic and outbreak-associated infections to sources: blending epidemiological data
Authors: COLE D. , GRIFFIN P. M. , FULLERTON K. E. , AYERS T. , SMITH K. , INGRAM L. A. , KISSLER B. , HOEKSTRA R. M. 
Published: April 2013

SUMMARYCommon sources of shiga toxin-producing Escherichia coli (STEC) O157 infection have been identified by investigating outbreaks and by case-control studies of sporadic infections. We conducted an analysis to attribute STEC O157 infections ascertained in 1996 and 1999 by the Foodborne Diseases Active Surveillance Network (FoodNet) to sources. Multivariable models from two case-control studies conducted in FoodNet and outbreak investigations that occurred during the study years were used to calculate the annual number of infections attributable to six sources. Using the results of the outbreak investigations alone, 27% and 15% of infections were attributed to a source in 1996 and 1999, respectively. Combining information from both data sources, 65% of infections in 1996 and 34% of infections in 1999 were attributed. The results suggest that methods to incorporate data from multiple surveillance systems and over several years are needed to improve estimation of the number of illnesses attributable to exposure sources.
The distributional effects of the Social Security windfall elimination provision
Authors: BROWN JEFFREY R. , WEISBENNER SCOTT J. 
Published: April 2013

AbstractOver five million state and local government employees have lifetime earnings that are divided between employment that is covered by the Social Security system and employment that is not covered. As Social Security benefits are a nonlinear function of covered lifetime earnings, the simple application of the standard benefit formula to covered earnings only would provide a higher replacement rate on those earnings than is appropriate given the individuals' total (covered plus uncovered) lifetime earnings. The Windfall Elimination Provision (WEP), established in 1983, is intended to correct this situation by applying a modified benefit formula to earnings of individuals with non-covered employment. This paper analyzes the distributional implications of the WEP and finds that it reduces benefits disproportionately for individuals with lower lifetime covered earnings. It discusses an alternative method of calculating the WEP that comes closer to preserving the intended redistribution of the system. In recognition of historical data limitations that prevent the Social Security Administration (SSA) from being able to implement this alternative method at present, the paper also analyzes two alternative ways of calculating the WEP that use the same information as the current WEP, are budget neutral, and come closer to maintaining the individual-level, cross-sectional progressivity of Social Security than does the existing WEP formula.
Belastungen in der Kindheit und dissoziative Symptomatik bei Patienten mit psychischen Störungen
Authors: Fiess Johanna , Steffen Astrid , Pietrek Christian , Rockstroh Brigitte 
Published: April 2013

Theoretischer Hintergrund: Dissoziative Symptome treten bei verschiedenen psychischen Störungen auf und werden bei einigen Störungen mit traumatischen Erfahrungen assoziiert. Fragestellung: Wird der Zusammenhang zwischen dissoziativer Symptomatik und belastenden Erfahrungen moduliert durch die Art der Erfahrung und das Alter zum Zeitpunkt der Belastung? Methode: Bei 82 Patienten (Borderline-Persönlichkeitsstörung, BPS; Major Depression Disorder, MDD) und 54 gesunden Kontrollpersonen wurden per Interview belastende Erfahrungen während Kindheit und Jugend (3 – 16 Jahre) ermittelt. Zusammenhänge zwischen Belastung und dissoziativer Symptomatik wurden regressionsanalytisch unter Berücksichtigung von Diagnose und komorbider Posttraumatischer Belastungsstörung (PTBS) untersucht. Ergebnisse: Dissoziative Symptomatik korreliert bei BPD und MDD (mit komorbider PTBS) positiv mit emotionalem (neben sexuellem) Missbrauch und mit Belastungen in der Pubertät. Schlussfolgerung: Therapeutische Berücksichtigung emotionaler und pubertärer Belastung könnte die (Behandlung erschwerende) dissoziative Symptomatik reduzieren.
Role of haem oxygenase in the renoprotective effects of soluble epoxide hydrolase inhibition in diabetic spontaneously hypertensive rats
Authors: Elmarakby Ahmed A. , Faulkner Jessica , Pye Chelsey , Rouch Katelyn , Alhashim Abdulmohsin , Maddipati Krishna Rao , Baban Babak 
Published: April 2013

We have shown previously that inhibition of sEH (soluble epoxide hydrolase) increased EETs (epoxyeicosatrienoic acids) levels and reduced renal injury in diabetic mice and these changes were associated with induction of HO (haem oxygenase)-1. The present study determines whether the inhibition of HO negates the renoprotective effect of sEH inhibition in diabetic SHR (spontaneously hypertensive rats). After 6 weeks of induction of diabetes with streptozotocin, SHR were divided into the following groups: untreated, treated with the sEH inhibitor t-AUCB {trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid}, treated with the HO inhibitor SnMP (stannous mesoporphyrin), and treated with both inhibitors for 4 more weeks; non-diabetic SHR served as a control group. Induction of diabetes significantly increased renal sEH expression and decreased the renal EETs/DHETEs (dihydroxyeicosatrienoic acid) ratio without affecting HO-1 activity or expression in SHR. Inhibition of sEH with t-AUCB increased the renal EETs/DHETEs ratio and HO-1 activity in diabetic SHR; however, it did not significantly alter systolic blood pressure. Treatment of diabetic SHR with t-AUCB significantly reduced the elevation in urinary albumin and nephrin excretion, whereas co-administration of the HO inhibitor SnMP with t-AUCB prevented these changes. Immunohistochemical analysis revealed elevations in renal fibrosis as indicated by increased renal TGF-β (transforming growth factor β) levels and fibronectin expression in diabetic SHR and these changes were reduced with sEH inhibition. Co-administration of SnMP with t-AUCB prevented its ability to reduce renal fibrosis in diabetic SHR. In addition, SnMP treatment also prevented t-AUCB-induced decreases in renal macrophage infiltration, IL-17 expression and MCP-1 levels in diabetic SHR. These findings suggest that HO-1 induction is involved in the protective effect of sEH inhibition against diabetic renal injury.
Effects of Simulated Angler Capture and Live‐Release Tournaments on Walleye Survival
Authors: Loomis John H. , Schramm Harold L. , Vondracek Bruce , Gerard Patrick D. , Chizinski Christopher J. 
Published: April 2013

AbstractWe examined the effects of acclimation water temperature,live‐well (LW) water temperature,and LW dissolved oxygen (DO) concentration on survival of adult Walleyes Sander vitreus subjected to simulated tournament conditions (angling,LW confinement,and weigh‐in procedures) under controlled laboratory conditions. We tested three acclimation temperatures (12,18,and 24°C),and three LW temperature differentials (ΔT = −4,0,and +4°C) were tested at each acclimation temperature. Survival was monitored after 8 h of LW confinement and during a 5‐d retention period in 1,700‐L tanks. None of the Walleyes that were acclimated to 24°C and subjected to simulated tournament procedures survived the 5‐d retention period; for fish subjected only to simulated angling at 24°C,survival during the 5‐d retention period was 29%. Five‐day survival was generally over 70% at acclimation temperatures of 12°C and 18°C,and we observed a significant interaction between acclimation temperature and ΔT; survival was greatest in LWs at −4°C ΔT for fish acclimated to 18°C and in LWs at +4°C ΔT for fish acclimated to 12°C. Best survival of Walleyes subjected to the stress of angling and tournament procedures was obtained at temperatures 6–8°C below the optimum temperature for adult Walleyes (i.e.,optimum = 20–22°C). Five‐day survival exceeded 70% when LW DO was 5 or 12–15 mg/L (at an acclimation and LW temperature of 18°C),but survival was 0% when DO was 2 mg/L. Anglers may increase survival of Walleyes through careful manipulation of LW temperature and DO when ambient temperature is at or below 18°C,but high mortality of angled and LW‐retained Walleyes should be expected when ambient water temperatures are 24°C or greater.
On the Metaphorical Connectivity of Cultural Sign Systems
Authors: Danesi Marcel 
Published: April 2013

AbstractTheories of culture based on signs and systems are found across the interdisciplinary spectrum. There seems to be a growing consensus across disciplines that the forms of culture (linguistic, material, aesthetic, ritualistic, etc.) are connected to each other in some way. With the advent of conceptual metaphor theory, this article claims that the cognitive mechanism (metaphor) connecting the forms can be found in this theoretical framework. It also puts forward the notion of metaform as a nonverbal counterpart to a conceptual metaphor. In this way, it is possible to link signs and systems to each other into a network of distributed meanings that constitute a culture.
Citation and Citationality
Authors: Nakassis Constantine V. 
Published: April 2013

AbstractThis essay explores the semiotics of citation. The citation is an act that re-presents some other event of discourse and marks that re-presentation as not(-quite) what it presences. The citation is a play of sameness and difference, identity and alterity, an interdiscursive calibration of an event of citing and a cited event, and is reflexive about that very fact. As such, citational acts can open up new social horizons of possibility, signification, and performative power. This essay investigates the citational underpinnings of the Fregean sense, Austinian performativity, and Derridean deconstruction. I give particular attention to Derrida's reading of Austin, and his development of the concept of citationality. As I argue, Derrida's insistence on the necessary possibility of citationality elides the fact that citations are always already achievements in context, and thus empirical facts about particular (types of) acts in the world. Not all acts are reflexive about their citationality, and this has consequences for their material form and their pragmatics. Finally, the essay turns to the recalcitrance of events of semiosis to being cited, in particular, to taboo speech. Taboo speech presents a case of speech that seemingly cannot be bracketed, where performative effect necessarily and always attains. As such cases show, citation brackets and suspends, but perhaps never totally.
Touching the Past: Materializing Time in Traumatic “Living History” Reenactments
Authors: Auslander Mark 
Published: April 2013

AbstractMany living history reenactors speak of “touching the past” in their performances. In nearly all instances, these profound experiences of intimate traffic with previous epochs and persons are brought about not through physical contact with historical artifacts but through deployments of replicas and props, including recently produced adornment, weaponry, vehicles, and tools. This essay explores the roles and functions of material reproductions or substitutes of historic artifacts in reenactment performances, and how these object-oriented practices often bring about powerful sensations of historic authenticity on the part of reenactors and their audiences. I give particular attention to the use of physical objects by those who seek to reenact traumatic events and experiences related to American histories of racial injustice, including experiences of slavery and Jim Crow racial violence.