bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden of multidrug-resistant bacteria among HIV-positive individuals in Ethiopia: A systematic review and meta-analysis
Authors: Assefa Muluneh , Amare Azanaw , Tigabie Mitkie , Girmay Getu , Setegn Abebaw , Wondmagegn Yenesew Mihret , Tamir Mebratu , Belete Debaka , Aynalem Melak , Belachew Teshome , Biset Sirak 
Published: August 2024

Background
Multidrug-resistant (MDR) bacteria are a significant cause of severe infections, particularly in human immunodeficiency virus (HIV)-positive individuals because of their weakened immunity. Since there was no previous pooled representative data regarding the MDR bacteria among HIV-positive individuals in Ethiopia, this systematic review and meta-analysis is required.

Methods
This study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A literature search was performed using PubMed, Medline, EMBASE, Google Scholar, Hinari, Web of Science, Science Direct, and African Journals Online databases. Data were extracted using Microsoft Excel 2019 and analyzed using STATA version 11.0 software. A random-effects model was used to estimate the pooled effect size of outcome variables across studies with a 95% confidence interval. The I2 statistic was used to check for heterogeneity. The presence of publication bias was determined using a funnel plot and Egger’s test with a p-value < 0.05 evidence of statistically significant bias.

Results
The pooled prevalence of MDR was 58.02% (95% CI: 46.32–69.73%) with high heterogeneity (I2 = 97.1%, (p < 0.001). In subgroup analysis, the highest multi-drug resistance was observed in the Oromia region (80.95%), patients with multiple infections (82.35%), and studies identified both Gram-positive and Gram-negative bacteria (61.45%). Furthermore, the pooled prevalence of MDR bacteria colonizing HIV-positive individuals was 48.76%. Regarding MDR species, Enterococci (77.41%) and Pseudomonas spp. (84.60%) were commonly identified in individuals with HIV infection.

Conclusion
Our study indicates a high burden of MDR among HIV-positive individuals in Ethiopia. The Oromia region, HIV patients with multiple infections, Pseudomonas spp., and Enterococci showed the highest MDR in the subgroup analysis. Therefore, regional hospitals should implement strategies to tackle MDR such as vaccination program, appropriate use of antibiotics, and further study on the associated factors of MDR bacteria in HIV are required.
Postpolypectomy Bleeding Gone Wrong: Primary Colonic Epithelioid Angiosarcoma
Authors: Bolla Rishi , Martinez Carolina , Metter David , Hilal Jonathan 
Published: August 2024

ABSTRACT
Epithelioid angiosarcoma is an aggressive form of angiosarcoma, and primary colonic tumors are extremely rare. We present the case of a 60-year-old man who presented with what initially appeared to be postpolypectomy bleeding. After undergoing repeat endoscopy, he was found to have epithelioid angiosarcoma of the transverse colon, and imaging further confirmed that it was the primary tumor site. Our patient underwent segmental resection of his transverse colon. The patient's initial presentation as postpolypectomy bleeding and his continued cancer-free survival after a relatively limited surgery are unique features not previously seen.
Revealing the New Nexus in Urban Unemployment Dynamics: The Relationship between Institutional Variables and Long-Term Unemployment in Colombia
Authors: Cardona Arenas Carlos David , Sierra Suárez Lya Paola , Trillas Jané Francesc 
Published: August 2024

Abstract
The aim of this study is to assess the impact of various institutional variables on the long-term unemployment rate (LAPU) in the Colombian urban labor market. Vector autoregressive models are estimated using microdata from the Great Integrated Household Survey (GEIH), which has national coverage. Monthly data were analyzed for the 13 major capital cities and their metropolitan areas, as well as for the group of 11 intermediate capital cities, resulting in a total of 24 main urban labor markets in Colombia. The dataset includes unionized individuals, individuals with verbal and written contracts, non-labor income, unemployed individuals with subsidies, and individuals receiving severance payments. The results indicate that the growth in the number of unionized employees and non-labor income contributes to increasing the persistence in the duration of unemployment in Colombia. A key finding is that a positive growth in the ratio – gap between individuals with written contracts versus verbal contracts reduces LAPU. This provides evidence of how reducing information asymmetries in the Colombian labor market can improve labor market outcomes and contribute to medium- and long-term social welfare in Colombian urban centers.
Influence of strut angle and radius on the energy absorption and failure mechanisms in 3-strut, 4-strut and 6-strut lattice structures
Authors: Ture Mustafa Okan , Evis Zafer 
Published: August 2024

Abstract
3D-printed truss structures have remarkable potential in the aerospace and weight-critical technologies fields. However, design parameters need to be carefully considered. A low overhang angle or diameter can result in discrepancies. This research presents an approach by examining the effect of strut overhang angle and radius on the mechanical properties of 3-, 4- and 6-strut lattice structures under compressive loading. 1.6- and 2.4-mm diameter struts were designed with 45°, 50°, 55° and 60° overhang angle strut lattices. Experiments were simulated and compared with test results for each parameter. Even if joint regions have little effect on specimens’ density, it has a remarkable effect on mechanical properties of the specimen. To simulate this, many studies were investigated to simulate joint regions. The study’s goal is to deepen the understanding of how design variations in strut lattice structures influence their energy-absorbing characteristic and mechanical behavior, using a combination of static tests and finite element analysis for validation. This insight is crucial for optimizing lattice design to balance weight, strength, and energy-absorbing capacity effectively. The experimental test result and numerical result showed rather good agreement. It is observed that joint regions, overhang angle, and diameters were the main parameters affecting specimens’ mechanical behavior.
A review: evaluating methods for analyzing kidney stones and investigating the influence of major and trace elements on their formation
Authors: Muhammed Fidan Suleman , Salih Musher Ismael , Omer Rebaz Anwar , Qader Aryan Fathulla , RashidIman Rzgar Faruq , Abdulkareem Eman Ibrahim 
Published: August 2024

Abstract
Kidney stone disease is a global concern, and its prevalence is increasing. The objective of this review is to provide a thorough analysis of the many analytical techniques used in the study of kidney stones and to investigate the significance of major and trace components in the development of kidney stone formation. The samples included organic (uric acid) and inorganic (calcium oxalate and carbonate apatite). To study kidney stone analysis methods like XRD, FTIR, SEM, and ICP-MS, a systematic literature review was conducted. The quantities and effects of main (calcium, oxalate, phosphate) and trace (magnesium, zinc, copper) elements in kidney stone development were also examined. The review shows that XRD and FTIR are best for evaluating kidney stone crystalline structure and content, whereas SEM gives rich morphological insights. Its trace element detection sensitivity makes ICP-MS unique. Calcium oxalate and calcium phosphate, the most common components, affect kidney stone development. Trace elements like magnesium prevent stone formation, whereas zinc and copper may encourage crystallisation. Results revealed significantly higher calcium levels in inorganic components compared to organic ones. Uric acid stones exhibited lower element content except for copper and selenium, likely originating from the liver. Carbonate apatite stones showed higher element concentrations, particularly magnesium, compared to calcium oxalate stones. Principal component analysis (PCA) identified three principal components, explaining 91.91 % of the variance. These components reflected specific co-precipitation processes of elements, with distinct distributions among different stone types. This variability in element content among stone types could serve as valuable guidance for patient dietary considerations.
Deep residual ensemble model for predicting remaining useful life of turbo fan engines
Authors: Selvaraj Sharanya , Narayanan Thulasi Jyothi , Johnrose Vijayakumari Muruga lal Jeyan , Selvaraj Karthikeyan 
Published: August 2024

Abstract
Capturing degradation trends from the Condition monitored signals is a proven technique for predicting the Remining Useful Life (RUL) of the equipment, which has gained more prominence in Prognostics and Health Management (PHM) in Industry 4.0. However, this process is tiresome and comprehending all the physical parameters of the system to construct a Health Index that characterize the health state is a complex process, especially if multiple sensors are involved. This work proposes a Deep residual ensemble model which constructs Fused Health Index (FHI) by harnessing temporal property of signals. The proposed Residual network integrates Bi-directional Long Short Term Memory (Bi-LSTM) and Deep Neural Network (DNN) which absorbs individual residuals of both the forward and reverse LSTMs that acts as an important feature to improve the overall prediction process. The work validated using CMAPPS dataset using various unique performance metrics to portray the effectiveness of the model.
Prediction models of intravenous glucocorticoids therapy response in thyroid eye disease
Authors: Zhang Haiyang , Wu Shuo , Hu Shuyu , Fan Xianqun , Song Xuefei , Feng Tienan , Zhou Huifang 
Published: August 2024

Background
Thyroid eye disease (TED) is an autoimmune orbital disease, with intravenous glucocorticoid (IVGC) therapy as the first-line treatment. Due to uncertain response rates and possible side effects, various prediction models have been developed to predict IVGC therapy outcomes.

Methods
A thorough search was conducted in PubMed, Embase, and Web of Science databases. Data extraction included publication details, prediction model content, and performance. Statistical analysis was performed using R software, including heterogeneity evaluation, publication bias, subgroup analysis, and sensitivity analysis. Forest plots were utilized for result visualization.

Results
Of the 12 eligible studies, 47 prediction models were extracted. All included studies exhibited a low-to-moderate risk of bias. The pooled area under the receiver operating characteristic curve (AUC) and the combined sensitivity and specificity for the models were 0.81, 0.75, and 0.79, respectively. In view of heterogeneity, multiple meta-regression and subgroup analysis were conducted, which showed that marker and modeling types may be the possible causes of heterogeneity (P < 0.001). Notably, imaging metrics alone (AUC = 0.81) or clinical characteristics combined with other markers (AUC = 0.87), incorporating with multivariate regression (AUC = 0.84) or radiomics analysis (AUC = 0.91), yielded robust and reliable prediction outcomes.

Conclusion
This meta-analysis comprehensively reviews the predictive models for IVGC therapy response in TED. It underscores that integrating clinical characteristics with laboratory or imaging indicators and employing advanced techniques like multivariate regression or radiomics analysis significantly enhance the efficacy of prediction. Our research findings offer valuable insights that can guide future studies on prediction models for IVGC therapy in TED.
ANALISIS KEBUTUHAN PENGEMBANGAN KOMPETENSI (AKPK) PEGAWAI PUSKESMAS SERPONG 2 TANGERANG SELATAN
Authors: Karyadi Karyadi , Rimadhoni Ramly Nur , Tryastuti Dini 
Published: August 2024

ABSTRACT Competency development is an effort to fulfill ASN competency needs. Every ASN has the right to obtain competency development. ASN competency standards are an embodiment of a description of the knowledge, skills, and behavior needed by an ASN in carrying out their duties. This competency includes 3 elements, namely Technical Competence, Managerial Competence, and Socio-Cultural Competence. The aim of this study is to describe Managerial competencies (Integrity, Teamwork, Communication, Orientation on Results, Public Service, Development of self and others, Managing Change, and Decision Making) and Social-Cultural Competence (Perekat Bangsa) to then be analyzed in order to obtain appropriate competence development results for employees. The research method used is Quantitative Descriptive. The sample in this study were 29 respondents with total sampling technique using inclusion criteria. Data were collected using the questionnaire method from the 2017 Permenpan & Rb competency dictionary. The analysis used in this study was univariate analysis. The results showed that there were employees who had not reached the good criteria in Managerial Competency in the category of cooperation with 1 employee, communication with 2 employees, orientation towards results 1 employee, public service with 1 employee, self-development and other people with 2 employees, managing change with 1 Employees and several recommendations for competency development for these employees are training for work team development, training for effective communication, training for organizational performance through learning, training for public services for government agencies, training for self-development and ASN professionalism, and training for adaptability.Keywords:
Pengaruh Metode Preview, Question, Read, Summarize, Test (PQRST) terhadap Keterampilan Membaca Pemahaman Siswa Kelas V MIS Al-Ikhwan Bukittinggi
Authors: HB Zulfahmi , Nurhafizah Suci , Basit Abdul 
Published: August 2024

Penelitian ini bertujuan untuk mendeskripsikan penerapan metode PQRST pada pembelajaran Bahasa Indonesia yang dapat meningkatkan keterampilan membaca pemahaman peserta didik di kelas V MIS Al-Ikhwan Bukittinggi. Metode penelitian ini adalah eksperimen dengan jenis penelitian kuantitatif. Penelitian ini dilaksanakan pada peserta didik kelas V MIS Al-Ikhwan Bukittinggi tahun ajaran 2023/2024 dan jumlah peserta didik 44 orang. Data penelitian ini diperoleh dari tes hasil belajar untuk melihat keberhasilan belajar peserta didik setelah pembelajaran menggunakan metode PQRST. Teknik analisis data yang digunakan uji hipotesis. Berdasarkan hasil analisis uji “t” dengan pengolahan data menggunakan SPSS diperoleh Sig (2-tailed) sebesar 0,074, thitung = 1,83 dan ttabel=1,68. Dengan dasar pengambilan keputusan thitung ttabel, yaitu 1,83 1,68 maka hipotesis Ha diterima dan H0 ditolak. Dapat disimpulkan bahwa nilai keterampilan membaca pemahaman yang diajar dengan metode preview, question, read, summarize, test (PQRST) lebih tinggi dibandingkan dengan nilai keterampilan membaca pemahaman peserta didik dengan metode ceramah. Dari hasil ini diharapkan pendidik dapat menggunakan metode preview, question, read, summarize, test sebagai alternatif metode pembelajaran membaca.
Fabrication and characterization of multifunctional, asymmetric bilayer films based on chitosan/gelatin/mesoporous bioactive glass nanoparticles for guided bone regeneration
Authors: Akhtar Muhammad Asim , Novak Jan , Radwansky Christian , Boccaccini Aldo. R. 
Published: August 2024

AbstractTwo-faced GBR membranes were fabricated by electrophoretic deposition (EPD) using a combination of biopolymers and mesoporous bioactive glass nanoparticles (MBGNs). The membrane design was aimed at leveraging the advantageous properties of both biopolymers and MBGNs. The dense composite layer consisted of chitosan (CS) incorporating MBGNs and it was functionalized with a phytotherapeutic drug, naringin (Nar). The porous layer consisted of CS-gelatin (Gel)- MBGNs as well as copper chelated chitosan (Cu(II)-CS)-Gel-MBGNs composites. EPD was conducted in direct current mode. The antibacterial activity of the membranes as a result of the presence of Cu(II) and Nar was confirmed. The films were cytocompatible when tested with MC3T3-E1 (pre-osteoblastic) and MG-63 (osteoblast like) cell lines. However, a slight cytotoxic effect of the releasing Cu(II) ions was determined. In contrast, Nar-loaded films revealed improved cell viability. The results indicate the high potential of EPD to fabricate bilayer structures for GBR applications.
Graphical abstract
Effect of adding fenugreek and <i>Nigella sativa</i> to white rice on postprandial glycemic and appetite responses in healthy individuals
Authors: Khan Imran , Shahid Afridi Muhammad , Ahmad Jamil , Johnson Stuart K. , Al-Rizeiqi Mohammed H. , Almajwal Ali Madi 
Published: August 2024

White rice is a high glycemic index food, and therefore different approaches are adopted to reduce its glycemic effect. The present study investigated the effect of adding fenugreek and Nigella sativa seed powder to white rice on glycemia, appetite, palatability, and gastrointestinal clinical manifestations in healthy subjects. In a randomized crossover design, 16 healthy subjects consumed white rice alone (control group), white rice with 2-g fenugreek seed powder or white rice with 4-g nigella seed powder on different occasions. Each test meal provided 50 g of available carbohydrates. Blood glucose, subjective appetite, and gastrointestinal manifestations were measured at fasting and postprandially for 2 h. Palatability of the test meals was also measured using a 9-point hedonic scale. The nigella meal resulted in significantly lower blood glucose concentration (31.25 mg/dL) at 30 min (p = 0.022), compared to the control meal (43.88 mg/dL) whereas fenugreek meal showed no significant effect. Moreover, the nigella meal significantly increased satiety ratings at 30 and 90 min (p = 0.035 and 0.018, respectively). The results demonstrated that the addition of nigella powder to white rice reduced its glycemic response and increased satiety, compared to the control meal. All test meals were judged as acceptable by the subjects and their consumption didn’t cause any gastrointestinal discomfort. Results of the current study demonstrated promising implications for reducing glycemic response of white rice, a commonly consumed high-glycemic index food.
Sodium-Glucose Cotransporter-2 Inhibitor and Glucagon-Like Peptide-1 Receptor Agonist Discontinuation in Patients with CKD
Authors: Gregg L. Parker , Richardson Peter A. , Nambi Vijay , Petersen Laura A. , Matheny Michael E. , Virani Salim S. , Navaneethan Sankar D. 
Published: August 2024

Key Points

Treatment discontinuation is common among patients with CKD prescribed sodium-glucose cotransporter-2 (SGLT2) inhibitors (discontinued in 37%) or glucagon-like peptide-1 receptor agonists (GLP-1 RA; discontinued in 47%).Discontinuation of SGLT2 inhibitors and GLP-1 RA was associated with recent hospitalizations, Black race, Hispanic ethnicity, and vascular disease.Discontinuation of both agents was associated with death and cardiovascular events.

Background
Little is known about the association of discontinuation of sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RA) with outcomes in patients with CKD.

Methods
We identified adults with CKD stages 3–4 from 2005 to 2022 in the Veterans Affairs health care system. Individuals with an incident prescription for SGLT2 inhibitors or GLP-1 RAs were included, with the first fill date considered the index date. Factors associated with time to first treatment discontinuation, defined as an interruption in SGLT2 inhibitor or GLP-1 RA prescription for ≥90 days, were studied using Cox proportional hazards regression models. Associations of discontinuation 90–179 and ≥180 days with death, myocardial infarction, coronary revascularization, hospitalization for heart failure, and ischemic stroke were assessed using Cox proportional hazards regression.

Results
Of 96,345 individuals who received an SGLT2 inhibitor and 60,020 who received a GLP-1 RA, at least one discontinuation occurred in 35,953 (37%) of SGLT2 inhibitor users and 28,407 (47%) of GLP-1 RA users. SGLT2 inhibitor users were 24% Black, 71% White, 71% age ≥70, and 84% with CKD stage 3a. GLP-1 RA users were 20% Black, 75% White, 63% age ≥70, and 81% with CKD stage 3a. Black race, Hispanic ethnicity, cerebrovascular disease, peripheral vascular disease, and ischemic heart disease were associated with discontinuation of both drug classes. Female sex and more advanced CKD stage were also associated with SGLT2 inhibitor discontinuation. SGLT2 inhibitor discontinuation ≥180 days was associated with death (adjusted hazard ratio [HR], 1.67; 95% confidence interval [CI], 1.58 to 1.77) and heart failure hospitalization (adjusted HR, 1.26; 95% CI, 1.13 to 1.40). GLP-1 RA discontinuation ≥180 days was associated with death (adjusted HR, 1.97; 95% CI, 1.87 to 2.07), myocardial infarction (adjusted HR, 1.23; 95% CI, 1.11 to 1.36), heart failure hospitalization (adjusted HR, 1.48; 95% CI, 1.33 to 1.64), and ischemic stroke (adjusted HR, 1.24; 95% CI, 1.14 to 1.35).

Conclusions
SGLT2 inhibitor and GLP-1 RA discontinuation was common and associated with harmful outcomes in adults with CKD.
Kinematic Source Properties of the 2023 Mw 7.7 Türkiye Earthquake Inferred from Near-Fault Strong Ground Motions
Authors: Nagasaka Yosuke , Nozu Atsushi 
Published: August 2024

Abstract
The 2023 Mw 7.7 Türkiye earthquake provided densely observed near-fault ground-motion data, which enabled us to investigate their characteristics and generations. This study aimed to obtain an intuitive understanding of the characteristics of near-fault strong ground motions and their relationship with kinematic source properties using a simple source model. Synthetic ground motions were calculated using the discrete wave number method and compared with observed ground motions. The observed strong motions were used after a time correction based on the first P-wave arrival. Results showed that near-fault pulse-like velocities (0.02–0.6 Hz) were generally explained by the simple kinematic source model that assumed a continuous rupture propagation along the faults. Comparisons at individual sites indicate the various rupture properties of the fault segments. Near-fault ground motions along the Narli segment were explained by the fault plane along the surface trace and not by aftershock distribution. A supershear rupture propagation speed is necessary for a part of the Amanos segment. Rupture stops and restarts were implied near the stepover along the Amanos segment. Empirical site factors estimated by generalized inversion techniques did not show peaks around the frequency of observed large velocity pulses, indicating that the velocity pulses were mainly generated by the source. The model bias and uncertainties were also examined to supplement the simplified subsurface structure used in the simulation. Our results will help to associate the qualitative and quantitative aspects of the kinematic source process with near-fault strong ground motions.