bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deconstructing Deep Active Inference: A Contrarian Information Gatherer
Authors: Champion Théophile , Grześ Marek , Bonheme Lisa , Bowman Howard 
Published: August 2024

Abstract
Active inference is a theory of perception, learning, and decision making that can be applied to neuroscience, robotics, psychology, and machine learning. Recently, intensive research has been taking place to scale up this framework using Monte Carlo tree search and deep learning. The goal of this activity is to solve more complicated tasks using deep active inference. First, we review the existing literature and then progressively build a deep active inference agent as follows: we (1) implement a variational autoencoder (VAE), (2) implement a deep hidden Markov model (HMM), and (3) implement a deep critical hidden Markov model (CHMM). For the CHMM, we implemented two versions, one minimizing expected free energy, CHMM[EFE] and one maximizing rewards, CHMM[reward]. Then we experimented with three different action selection strategies: the ε-greedy algorithm as well as softmax and best action selection. According to our experiments, the models able to solve the dSprites environment are the ones that maximize rewards. On further inspection, we found that the CHMM minimizing expected free energy almost always picks the same action, which makes it unable to solve the dSprites environment. In contrast, the CHMM maximizing reward keeps on selecting all the actions, enabling it to successfully solve the task. The only difference between those two CHMMs is the epistemic value, which aims to make the outputs of the transition and encoder networks as close as possible. Thus, the CHMM minimizing expected free energy repeatedly picks a single action and becomes an expert at predicting the future when selecting this action. This effectively makes the KL divergence between the output of the transition and encoder networks small. Additionally, when selecting the action down the average reward is zero, while for all the other actions, the expected reward will be negative. Therefore, if the CHMM has to stick to a single action to keep the KL divergence small, then the action down is the most rewarding. We also show in simulation that the epistemic value used in deep active inference can behave degenerately and in certain circumstances effectively lose, rather than gain, information. As the agent minimizing EFE is not able to explore its environment, the appropriate formulation of the epistemic value in deep active inference remains an open question.
Top-Down Priors Disambiguate Target and Distractor Features in Simulated Covert Visual Search
Authors: Theiss Justin D. , Silver Michael A. 
Published: August 2024

Abstract
Several models of visual search consider visual attention as part of a perceptual inference process, in which top-down priors disambiguate bottom-up sensory information. Many of these models have focused on gaze behavior, but there are relatively fewer models of covert spatial attention, in which attention is directed to a peripheral location in visual space without a shift in gaze direction. Here, we propose a biologically plausible model of covert attention during visual search that helps to bridge the gap between Bayesian modeling and neurophysiological modeling by using (1) top-down priors over target features that are acquired through Hebbian learning, and (2) spatial resampling of modeled cortical receptive fields to enhance local spatial resolution of image representations for downstream target classification. By training a simple generative model using a Hebbian update rule, top-down priors for target features naturally emerge without the need for hand-tuned or predetermined priors. Furthermore, the implementation of covert spatial attention in our model is based on a known neurobiological mechanism, providing a plausible process through which Bayesian priors could locally enhance the spatial resolution of image representations. We validate this model during simulated visual search for handwritten digits among nondigit distractors, demonstrating that top-down priors improve accuracy for estimation of target location and classification, relative to bottom-up signals alone. Our results support previous reports in the literature that demonstrated beneficial effects of top-down priors on visual search performance, while extending this literature to incorporate known neural mechanisms of covert spatial attention.
A Hail Climatology for Canada Using a Lightning Proxy
Authors: Brunet Dominique , Brimelow Julian 
Published: August 2024

Abstract
Hail is a significant weather hazard in Canada, but its spatial and temporal distribution is poorly understood. We compiled a Canadian hail report database for 2005–22, containing 7000 unique entries with estimates of the timing and location of the hail reports and estimated hail diameter. We developed a methodology to construct an estimate of the hail climatology across Canada using manual hail observations at airports and a lightning proxy. First, we estimated the probability of hail occurrence at airport locations across the country at any given hour using Bayesian inference. Next, we interpolated in space the probabilities to obtain smooth prior probabilities of hail occurrence at any location in Canada. Then, we refined these probabilities using lightning flash density as a proxy for the likelihood of hail, severe hail (diameter greater than 20 mm), or significant severe hail (diameter greater than 50 mm). Finally, we aggregated the posterior probabilities of hail, severe hail, and significant severe hail over time and space and compared them with the number of reports found in the 2005–22 Canadian hail database. Our results indicate that the posterior probabilities of hail are not consistent with the observed hail reports and suggest that there are many gaps in hail reporting in Canada.
Observed Variability in Convective Cell Characteristics and Near-Storm Environments across the Sea- and Bay-Breeze Fronts in Southeast Texas
Authors: Sharma Milind , Rapp Anita D. , Nowotarski Christopher J. , Brooks Sarah D. 
Published: August 2024

Abstract
During the DOE Atmospheric Radiation Measurement (ARM) Tracking Aerosol Convection Interactions Experiment (TRACER) IOP spanning June–September 2022, two fixed ARM sites and a mobile team concurrently sampled the airmass heterogeneity across sea- and bay-breeze fronts around the greater Houston metropolitan region. Here, we quantify the spatiotemporal variability between maritime (coastal/bay side of breeze fronts) and continental (inland side of breeze fronts) air masses over 15 IOP days characterized by strong sea-breeze forcing. We analyze environmental profile data from 177 radiosondes and use S- and C-band radar data to track and quantify the variability in attributes of more than 2300 shallow and transitioning cells across different air masses. The composite analysis of environmental profiles indicates that during the early afternoon, the sea-breeze maritime air mass exhibits lower convective available potential energy (CAPE) than the bay-breeze maritime air mass. As the sea breeze advances inland with time, CAPE within the maritime air mass exceeds that of the continental air mass to the north of the breeze fronts. In general, maritime cells have a larger mean composite reflectivity and cell widths than continental cells; however, the response varies between shallow and transitioning cells. Mean composite 20-dBZ echo-top heights, however, are similar across air masses for both shallow and transitioning cells. The continental and maritime inflow air mass for transitioning cells has significantly different mean values for mixed-layer entrainment CAPE, lifted condensation level, level of free condensation, boundary layer depth, and diluted equilibrium level. For shallow cells, only total precipitable water shows a significant difference.

Significance Statement
The greater Houston metropolitan area is a natural laboratory for understanding the individual impacts of background meteorology and aerosols on convective clouds. Due to its proximity to the Gulf Coast and Galveston Bay, the Houston region experiences a diurnal precipitation cycle in the summer, driven by convection triggered from sea- and bay-breeze fronts. These fronts act as a boundary between air masses with distinct thermodynamic and environmental characteristics. Convergence along these fronts and interactions between storm outflow and the fronts facilitate convection initiation in different mesoscale air masses. This study quantifies the heterogeneity among these air masses while investigating their influence on cloud microphysics. We find that the effect of airmass heterogeneity is more pronounced for the bulk microphysical properties in shallow clouds.
How do Social Achievement Goals Affect Early Adolescents’ Academic Engagement? The Role of Feeling Stressed and Lonely
Authors: Shim Sungok Serena , Cho Yoonjung , Helsper C. Addison , Kiefer Sarah M. , Wang Cen 
Published: August 2024

Research has established the significance of social achievement goals in shaping adolescents’ academic engagement. However, the precise mechanisms underpinning this connection remain incomplete. In two studies involving U.S. middle school students (Study 1 N = 212, Study 2 N = 318), we explored the relationship between social achievement goals, academic adjustment, and the mediating role of social distress and loneliness. High social development goals related to reduced social stress and loneliness, leading to enhanced classroom engagement. In contrast, social demonstration-avoidance goals were linked to elevated loneliness and stress, resulting in diminished classroom engagement. While the mediation effect was unclear for social demonstration-approach goals, they exhibited direct associations with unfavorable classroom engagement indicators. These findings illuminate the intricate dynamics between social achievement goals and academic engagement among early adolescents, emphasizing the role of social distress and loneliness in shaping their classroom experience.
Virtual non-contrast images in photon-counting computed tomography: impact of different contrast phases
Authors: Gadsbøll Eva Laurin , Aurumskjöld Marie-Louise , Holmquist Fredrik , Baubeta Erik 
Published: August 2024

Background Photon-counting computed tomography (PCCT) enables new ways of image reconstruction, e.g. material decomposition and creation of virtual non-contrast (VNC) series with higher resolution and lower radiation dose than standard computed tomography (CT). Clinical experiences of this are limited. Purpose To compare true non-contrast (TNC) series with VNC series derived from non-enhanced (VNCu), arterial phase (VNCa) and portal venous phase (VNCv) in clinically approved PCCT. Material and Methods A total of 45 clinical, tri-phasic abdominal CT scans from the PCCT Naetom Alpha, between February 2022 and November 2022, were retrospectively assessed. Placing a region of interest in six different locations in each VNC series – right liver parenchyma, left liver parenchyma, spleen, aorta, erector spinae muscle, and in the subcutaneous fat – absolute Hounsfield values (HU) and standard deviations (SD) were collected. Differences in HU (ΔHU) were compared and statistically analyzed. Results Statistically significant differences between VNC and TNC were seen in all measurements, with the largest difference in the subcutaneous fat and the smallest difference in the erector spinae muscle. Only small differences were seen between VNCa and VNCv, where the largest differences were seen in the left and right liver lobes. Conclusion VNC images from the first-generation clinically approved PCCT showed a significant difference between VNC and TNC images. The differences vary with the type of tissue. Only small differences were seen depending from which contrast phase the VNC was derived.
Thyroid-disrupting effects of bisphenol S in male Wistar albino rats: Histopathological lesions, follicle cell proliferation and apoptosis, and biochemical changes
Authors: Bostancı Müşerref , Kaptaner Burak , Doğan Abdulahad 
Published: August 2024

In this presented study, the aim was to investigate the toxic effects of bisphenol S (BPS), one of the bisphenol A analogues, on the thyroid glands of male Wistar albino rats. Toward this aim, the rats ( n = 28) were given a vehicle (control) or BPS at 3 different doses, comprising 20, 100, and 500 mg/kg of body weight (bw) via oral gavage for 28 days. According to the results, BPS led to numerous histopathological changes in the thyroid tissue. The average proliferation index values among the thyroid follicular cells (TFCs) displayed increases in all of the BPS groups, and significant differences were observed in the BPS-20 and BPS-100 groups. The average apoptotic index values in the TFCs were increased significantly in the BPS-500 group. The serum thyroid-stimulating hormone and serum free thyroxine levels did not show significant changes after exposure to BPS; however, the serum free triiodothyronine levels displayed significant decreases in all 3 of the BPS groups. BPS was determined to cause significant increases in the antioxidant enzyme activities of catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, as well as a significantly decreased content of reduced glutathione. The malondialdehyde level in the thyroid tissue was elevated significantly in the BPS-500 group. The data obtained herein revealed that BPS has thyroid-disrupting potential based on structural changes, follicle cell responses, and biochemical alterations including a decreased serum free triiodothyronine level and increased oxidative stress.
Neisseria gonorrhoeae isolates resistant to extended spectrum cephalosporins and macrolides isolated from symptomatic men in western Kenya
Authors: Agingu Walter , Otieno Fredrick , Dibondo Ezekiel , Wambua Patriciah , Le Van Adriana , Jerse Ann , Garges Eric , Mehta Supriya D 
Published: August 2024

Background We characterized the antimicrobial resistance (AMR) profiles of Neisseria gonorrhoeae (NG) isolated from symptomatic men at a sexually transmitted infection clinic in Kisumu, Kenya. Methods Two urethral swabs were obtained from symptomatic men between 2020 and 2022, one for Gram’s stain and the other inoculated directly onto modified Thayer-Martin media containing 1% VCNT and 1% IsoVitaleX enrichment. Culture results were confirmed by colony morphology, Gram’s stain and oxidase test. Duplicate isolates were shipped to Uniformed Services University for confirmation and characterization. Susceptibility to eight drugs was assessed by E-test. Agar dilution confirmed resistance to ceftriaxone, cefixime, and azithromycin. Susceptibility, intermediate resistance (IR), and resistance (R) were determined according to published criteria. Results Of 154 enrolled participants, 112 were culture-positive for NG. Agar dilution results in 110 (98.2%) showed the following: azithromycin-R (1.8%), and 4.5% R or IR to ceftriaxone or cefixime: ceftriaxone-R (0.9%), ceftriaxone-IR (2.7%), and cefixime-IR (2.7%). By E-test, most isolates were IR or R to tetracycline (97.2%), penicillin (90.9%), and ciprofloxacin (95.4%). Conclusions We detected NG with resistance to azithromycin and ceftriaxone, indicating a growing threat to the current Kenyan dual syndromic treatment of urethritis with cephalosporin plus macrolides. Ongoing AMR surveillance is essential for effective drug choices.
HIV-related knowledge, risk perception, and minority stressors among South Asian sexual minority men in the United States
Authors: Sharma Akshay , Gebrezgi Feaven , Hamilton April , Boyd Sara , Sallabank Gregory 
Published: August 2024

Background South Asian gay, bisexual, and other men who have sex with men (GBM) in the United States have been persistently overlooked in HIV research and programming. To address this limitation, this article describes their HIV-related knowledge, risk perception, and minority stressors, with a focus on identifying variations between American-born individuals and immigrants. Methods Participants were recruited from April-July 2022 through social media advertising and peer referral and surveyed about their sociodemographic and HIV-related behavioral characteristics. Previously validated scales were used to assess their HIV-related knowledge, risk perception, disclosure of sexual identity, experienced homophobia, and perceived racism within the sexual and gender minority community. Mann-Whitney-Wilcoxon tests were conducted to compare those born in the United States and those born abroad. Results Of the 112 participants, 26 (23.21%) were American-born individuals and 86 (76.79%) were immigrants. Despite similar levels of sexual risk behaviors, such as having multiple male sex partners, engaging in condomless anal sex, and using alcohol or drugs immediately before or during sex, immigrants had lower levels of HIV-related knowledge ( p = .0480) and risk perception ( p = .0114) compared to American-born individuals. Immigrants were also less likely to have disclosed their sexual identity to family, friends, and society compared to American-born individuals ( p = .0004). No differences were identified with respect to experiences of homophobia ( p = .2303) or perceptions of racism ( p = .4011). Conclusion Comprehensive HIV prevention efforts that address the social and cultural norms of South Asian GBM in the United States are needed.
Ethical risks in robot health education: A qualitative study
Authors: Mei ZiQi , Jin ShengJi , Li WeiTong , Zhang SuJu , Cheng XiRong , Li YiTing , Wang Meng , Song YuLei , Tu WenJing , Yin HaiYan , Wang Qing , Bai YaMei , Xu GuiHua 
Published: August 2024

Background As health education robots may potentially become a significant support force in nursing practice in the future, it is imperative to adhere to the European Union’s concept of “Responsible Research and Innovation” (RRI) and deeply reflect on the ethical risks hidden in the process of intelligent robotic health education. Aim This study explores the perceptions of professional nursing professionals regarding the potential ethical risks associated with the clinical practice of intelligent robotic health education. Research design This study adopts a descriptive phenomenological approach, employing Colaizzi’s seven-step method for data analysis. Participants and research context We conducted semi-structured interviews with 17 nursing professionals from tertiary comprehensive hospitals in China. Ethical considerations This study has been approved by the Ethics Committee of the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Second Chinese Medicine Hospital. Findings Nursing personnel, adhering to the principles of RRI and the concept of “person-centered” care, have critically reflected on the potential ethical risks inherent in robotic health education. This reflection has primarily identified six themes: (a) threats to human dignity, (b) concerns about patient safety, (c) apprehensions about privacy disclosure, (d) worries about implicit burdens, (e) concerns about responsibility attribution, and (f) expectations for social support. Conclusions This study focuses on health education robots, which are perceived to have minimal ethical risks, and provides rich and detailed insights into the ethical risks associated with robotic health education. Even seemingly safe health education robots elicit significant concerns among professionals regarding their safety and ethics in clinical practice. As we move forward, it is essential to remain attentive to the potential negative impacts of robots and actively address them.
Cancer Awareness, Cause Recognition, and Sources of Information Among Japanese Students: A Repeated Cross-Sectional Nationwide Survey
Authors: Yokoshima Tsuyoshi , Sugisaki Koshu 
Published: August 2024

Objectives Cancer education has been promoted under the Basic Plan for Cancer Education in Japan. We conducted a repeated cross-sectional survey of Japanese students to determine changes in attitudes regarding cancer over time. Methods A nationwide survey of fifth-grade elementary students was conducted in February 2013. A repeated cross-sectional survey was conducted following previous studies with second-year high school students in February 2019, as second-year high school students in 2019 corresponded to the generation of fifth-grade students in 2013. The self-administered, multiple-choice questionnaire inquired about the awareness of cancer and its causes and sources of cancer information. Statistical analyses were performed by calculating the percentage of selections and 95% confidence intervals for each question. Results The differences between values in 2019 and 2013 were examined. Responses were received from 94 schools (44.1%) in 2013 and 114 schools (52.8%) in 2019. After excluding incomplete responses, valid responses from 2213 and 3822 respondents, respectively, were analyzed. Desirable changes over time were observed in awareness. Increasing age was associated with a rise in misperceptions and a decline in desirable rather than undesirable perceptions of the causes of cancer. The Internet was a common source of information among high school students, followed by health education at school. Conclusion Cancer education in schools should aim to counteract misconceptions and promote positive, evidence-based information. Improving perceptions of cancer screening could increase intentions of undergoing screening. Additionally, presenting cancer information using social networking sites could help promote cancer prevention among junior high and high school students.
Factor Xa Inhibitors Versus Vitamin K Antagonists in Atrial Fibrillation Patients with End-Stage Kidney Disease on Dialysis: A Meta-Analysis
Authors: Xiong Meimei , Guo Linjuan , Wan Yun 
Published: August 2024

Background Atrial fibrillation (AF) is prevalent among patients with end-stage kidney disease (ESKD) undergoing dialysis, and both conditions are associated with a heightened risk of cardiovascular diseases. Anticoagulation is essential for preventing thromboembolic complications in these patients. This study aimed to evaluate the effects of factor Xa inhibitors compared to vitamin K antagonists (VKAs) for AF patients on dialysis. Methods A comprehensive search of PubMed and Embase databases was conducted to identify relevant studies published up to June 2024. Eligible studies compared factor Xa inhibitors (rivaroxaban, apixaban, edoxaban) with VKAs in AF patients on dialysis, with primary outcomes of stroke or systemic embolism(SSE) and major bleeding. Results A total of 7 studies (3 randomized controlled trials and 4 observational cohorts) were included. For the RCTs, the use of factor Xa inhibitors was associated with a reduced risk of SSE compared to VKAs (odds ratio [OR] = 0.37, 95% confidence interval [CI]:0.15–0.93). There was no significant difference in the risk of major bleeding events between the two groups (OR = 0.65, 95%CI:0.32–1.33). Observational cohort studies yielded similar results with a decreased risk of SSE (hazard ratio [HR] = 0.74, 95%CI:0.57–0.96) and no significant difference in major bleeding (HR = 0.87, 95%CI:0.62–1.22). No differences in treatment effect between apixaban and rivaroxaban were observed for efficacy (p-interaction = 0.44) and safety (p-interaction = 0.21) outcomes. Conclusion Factor Xa inhibitors, particularly apixaban and rivaroxaban, were associated with a lower risk of SEE without an increase in major bleeding, which might be convenient alternatives to VKAs in managing AF in patients with ESKD on dialysis.