bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptation and validation of a quarter-of-life crisis questionnaire – The Developmental Crisis Questionnaire (DCQ-12)
Authors: Kulik Agnieszka , Dacka Monika , Jurek Krzysztof , Mazur Natalia 
Published: June 2024

Cel pracyCelem artykułu jest przedstawienie polskiej adaptacji Kwestionariusza Kryzysu Rozwojowego (DCQ-12). W Polsce obecnie brakuje narzędzia do pomiaru kryzysu ćwierć życia, co utrudnia empiryczne badania i zrozumienie tego zjawiska. Kwestionariusz DCQ-12, opracowany przez Petrova i współpracowników służy jako niezależne narzędzie do badania kryzysu rozwojowego u dorosłych.MetodaBadanie przeprowadzono online przez zewnętrzną firmę specjalizującą się w panelach badawczych. Próba obejmowała łącznie 1176 osób. W celu oceny właściwości psychometrycznych skali przeprowadzono analizy struktury wewnętrznej, w tym analizy czynnikowe eksploracyjne i konfirmacyjne oraz ocenę trafności.WynikiAnalizy statystyczne wskazują, że polska adaptacja DCQ-12 jest wiarygodnym narzędziem do badania nasilenia kryzysu ćwierć życia i jego komponentów. Uzyskane wyniki potwierdzają strukturę narzędzia, a właściwości psychometryczne w polskim badaniu są porównywalne do danych pierwotnych; wartość alfa Cronbacha dla całej skali wyniosła 0,78, co sugeruje, że rzetelność narzędzia jest zadowalająca i akceptowalna.WnioskiPolska wersja Kwestionariusza Kryzysu Rozwojowego wykazuje dobre właściwości psychometryczne. Jej wykorzystanie w praktyce terapeutycznej może być szczególnie korzystne dla lepszego poznania różnych aspektów kryzysu ćwierć życia.
The treatment of chronic wounds using bacteriophages
Authors: Bil Katarzyna , Kiełbasa Justyna , Kowalczyk Agata , Zozula Natalia , Latała Aleksandra , Ślesicka Iga , Rykucka Aleksandra , Wąs Marcin , Przestrzelska Magda , Tomczewska Zuzanna 
Published: June 2024

Introduction and aim of study: Chronic wounds are increasingly challenging global healthcare. These wounds, which take over 3 months to heal, are complicated by untreated infections and the formation of biofilm, hindering healing and antibiotic effectiveness. To tackle these issues, new treatments like bacteriophage therapy are being explored. Bacteriophages, viruses that target bacteria, offer promise in overcoming antibiotic resistance. However, their use presents challenges that need to be addressed.
Material and methods: Our review is based on the analysis of materials collected in Pubmed, Elsevier and other scientific articles using keywords: “chronic wound”, “chronic wounds infection”, “biofilms”, “MDR”, “bacteriophage”, “phage therapy”.
Conclusions: The rise of chronic wounds due to resistant infections poses a significant challenge for patients and healthcare systems. Multidrug-resistant bacteria, often forming biofilm, evade current treatments, urging the search for alternatives. Phage therapy, showing efficacy against various stubborn infections, including those from surgery or diabetes, gains attention. Advanced delivery systems enhance targeted treatment, while phage cocktails improve effectiveness, especially against multiple resistant strains. Safety is generally observed, but larger trials are needed. Though not a replacement for antibiotics, phage therapy offers hope, needing robust clinical validation. While challenges exist, its societal, commercial, and economic benefits suggest a promising future beyond clinical use.
Breast self-examination among community midwife and lady health visitor students in Pakistan
Authors: Bibi Afsha , Khan Aana 
Published: June 2024

Background/Aims Breast self-examination allows women to check their breasts for changes or abnormalities, such as lumps, bumps and other irregularities. The purpose of this study was to evaluate understanding of performing a breast self-examination among lady health visitor and community midwifery students in Pakistan. Methods This descriptive cross-sectional study was conducted from December 2022–April 2023 with 50 students recruited through convenient sampling. Data were collected using a structured questionnaire. Participants' understanding of breast self-examination was categorised as good (>70%), moderate (50–70%) or poor (<50%) based on their score. Results Only one participant had received any training on breast self-examination, and all participants reported that they would like training in future. Only 10.0% of participants had a moderate understanding of breast self-examination, while the remaining 90.0% had poor understanding. Conclusions There is a significant lack of knowledge about breast self-examination among lady health visitors and midwifery students in Pakistan. There is a need for education and awareness campaigns on breast self-examination to improve understanding.
Impact of the midwife-led care model on mode of birth: a systematic review and meta-analysis
Authors: Fitriana Farida , Ningrum Astika Gita , Izzati Dwi , Ferdinandus Euvanggelia Dwilda , Sudaryanti Lestari , Afrina Visky , Rahmawati Nur Anisah , Pamintuan Marilou 
Published: June 2024

Background/Aims Increased rates of caesarean sections globally have potential short- and long-term impacts for mothers and babies. Research on models of care and mode of birth has reported varied results. The aim of this study was to analyse the relationship between the midwife-led model of care and mode of birth. Methods This systematic review and meta-analysis searched PubMed, Scopus and Web of Science. Quantitative full-text open access research articles published between 2010 and 2023 in Indonesian or English were included. Research that assessed the relationship between the model and birth planning were excluded. Results A total of 16 articles were included. Two were experimental, and the remaining 14 were observational, with a total sample of 125 201 people. The midwife-led model supported spontaneous vaginal birth (odds ratio: 1.64, P=0.01) when compared to other models. Conclusions Implementing the midwife-led model of care may increase the likelihood of physiological birth and reduce the incidence of caesarean section, especially in low-risk pregnancies.
Telehealth vs in-person education for enhancing self-care of ostomy patients (Self-Stoma): Protocol for a noninferiority, randomized, open-label, controlled trial
Authors: Iovino Paolo , Vellone Ercole , Campoli Alessia , Tufano Carmelina , Esposito Maria Rosaria , Guberti Monica , Bolgeo Tatiana , Sandroni Cinzia , Sili Alessandro , Manara Duilio Fiorenzo , Alvaro Rosaria , Rasero Laura , Villa Giulia 
Published: June 2024

Introduction
Postoperative patients with ostomies experience significant changes in their lives as a result of the device implantation. Self-care is important to improve their health outcomes. Telehealth provides an opportunity to expand access to self-care education.

Aim
This is a multicenter, non-inferiority randomized, open-label, controlled trial to evaluate the non-inferiority of a telehealth intervention to the standard in-person approach in improving self-care behaviors.

Methods and analysis
Three hundred and eighty-four patients aged ≥ 18 years, with a recently placed ostomy, no stomal/peristomal complications, and documented cognitive integrity will be randomly assigned (1:1) to receive either a telehealth intervention (four remote educational sessions) or a standard educational approach (four in-person sessions) delivered in outpatient settings. Every session (remote and in-person) will occur on Days 25, 32, 40, and 60 after discharge. Follow-ups will occur 1, 3, and 6 months after the last intervention session. Primary outcome is self-care maintenance measured using the Ostomy Self-care Index (OSCI). Secondary outcomes include self-care monitoring, self-care management, self-efficacy (OSCI), quality of life (Stoma specific quality of Life), depression (Patient Health Questionnaire-9), adjustment (Ostomy Adjustment Inventory-23), stomal and peristomal complication rates, healthcare services utilization, mobility, and number of working days lost. Analyses will be performed per intention-to-treat and per protocol.

Ethics and dissemination
This study has been approved by the Institutional Review Board of the main center (registration number: 119/22). Following completion of the trial, dissemination meetings will be held to share the results of the study with the participants and the health-care team. Adoption of telehealth technologies for ostomy patients can improve service organization by ensuring better integration and continuity of care. If the remote intervention produces comparable effects to the in-person intervention, it would be wise to make telehealth education an alternative treatment for addressing the educational needs of uncomplicated postoperative ostomy patients.

Trial registration
ClinicalTrials.gov (identifier number: NCT05796544).
Incidence and predictors of acute kidney injury among adults admitted to the medical intensive care unit of a Comprehensive Specialized Hospital in Central Ethiopia
Authors: Ashine Taye Mezgebu , Mekonnen Migbar Sibhat , Heliso Asnakech Zekiwos , Wolde Yesuneh Dejene , Babore Getachew Ossabo , Bushen Zerihun Demisse , Ereta Elias Ezo , Saliya Sentayehu Admasu , Muluneh Bethelhem Birhanu , Jemal Samrawit Ali 
Published: June 2024

Background
Acute kidney injury is a prevalent complication in the Intensive Care Unit (ICU) and a significant global public health concern. It affects approximately 13 million individuals and contributes to nearly two million deaths worldwide. Acute kidney injury among Intensive Care Unit patients is closely associated with higher rates of morbidity and mortality. This study aims to assess the incidence of acute kidney injury and identify predictors among adult patients admitted to the medical Intensive Care Unit.

Method
A retrospective follow-up study was conducted by reviewing charts of 317 systematically selected patients admitted to the Intensive Care Unit from September 1, 2018, to August 30, 2022, in Wachemo University Nigist Ellen Mohammed Memorial Comprehensive Specialized Hospital. The extraction tool was used for the data collection, Epi-data version 4.6.0 for data entry, and STATA version 14 for data cleaning and analysis. The Kaplan-Meier, log-rank test, and life table were used to describe the data. The Cox proportional hazard regression model was used for analysis.

Results
Among the total study participants, 128 (40.4%) developed Acute Kidney Injury (AKI). The incidence rate of Acute Kidney Injury was 30.1 (95% CI: 25.33, 35.8) per 1000 person-days of observation, with a median survival time of 23 days. It was found that patients with invasive mechanical ventilation (AHR = 2.64; 95% CI: 1.46–4.78), negative fluid balance (AHR = 2.00; 95% CI: 1.30–3.03), hypertension (AHR = 1.6; 95% CI: 1.05–2.38), and a vasopressor (AHR = 1.72; 95% CI: 1.10–2.63) were independent predictors of acute kidney injury.

Conclusion
The incidence of Acute Kidney Injury was a major concern in the ICU of the study area. In the intensive care unit (ICU), it was found that patients with vasopressors, invasive mechanical ventilation, negative fluid balance, and chronic hypertension were independent predictors of developing AKI. It would be better if clinicians in the ICU provided targeted interventions through close monitoring and evaluation of those patients with invasive ventilation, chronic hypertension, negative fluid balance, and vasopressors.
Modes of HIV transmission among young women and their sexual partners in Ukraine
Authors: Zeziulin Oleksandr , Kornilova Maryna , Deac Alexandra , Morozova Olga , Varetska Olga , Pykalo Iryna , Dumchev Kostyantyn 
Published: June 2024

Background
Ukraine has the second-largest HIV epidemic in Europe, with most new cases officially attributed to heterosexual transmission. Indirect evidence suggested substantial HIV transmission from people who inject drugs (PWID) to their sexual partners. This study examined the extent of heterosexual HIV transmission between PWID and non-drug-using adolescent girls and young women (AGYW).

Methods
A cross-sectional survey recruited AGYW diagnosed with heterosexually-acquired HIV between 2016 and 2019 in nine regions of Ukraine. AGYW were asked to identify and refer their sexual partners (‘Partners’), who subsequently underwent HIV testing, and, if positive, HCV testing. Both AGYW and Partners completed an interview assessing HIV risk behaviors prior to AGYW’s HIV diagnosis.

Results
In August-December 2020, we enrolled 321 AGYW and 64 Partners. Among the Partners, 42% either self-reported IDU or were HCV-positive, indicating an IDU-related mode of HIV transmission. PWID Partners were more likely to report sexually transmitted infections (STI) and had lower educational levels. Of the 62 women who recruited at least one Partner, 40% had a PWID Partner. Within this subgroup, there was a higher prevalence of STIs (52% vs. 24%) and intimate partner violence (36% vs. 3%). Condom use was less common (52% vs. 38% reporting never use), and frequent alcohol or substance use before sex was higher (48% vs 30%) among AGYW with PWID Partner, although this difference did not reach statistical significance. Notably, 52% of women were aware of their Partners’ IDU.

Conclusion
At least 40% of heterosexual transmission among AGYW in Ukraine can be linked to PWID partners. Intensified, targeted HIV prevention efforts are essential for key and bridge populations (PWID and their sexual partners), addressing the biological and structural determinants of transmission between key and bridge populations, such as IDU- and HIV status disclosure, STIs, IPV, and stigma.
Impacts of Long COVID on workers: A longitudinal study of employment exit, work hours and mental health in the UK
Authors: Reuschke Darja , Houston Donald , Sissons Paul 
Published: June 2024

Background
The COVID-19 pandemic has had enormous implications for the world of work. However, there has been relatively little focus on the employment and workforce challenges of the virus in relation to workforce health, beyond the immediate management of the spread of the disease. There is an important gap in understanding the ongoing workforce issues created by the significant incidence of Long COVID in the population.

Aim
This paper examines the effects of Long COVID on employment and workers’ mental health to contribute to understanding of work-limiting health conditions and to offer policy implications for COVID-19 and similar health conditions on employment and the workforce.

Methods
A large national panel study for the UK is used to estimate the likelihood of exiting employment as well as on changes in working hours and general mental health and happiness of those who remain in work. The sample includes individuals 16 years and older who were in employment in January/February 2020 and followed during the pandemic 2020–2021. Long COVID is self-reported in the data. Informed by conceptual consideration of employment protection in the UK, two groups of individuals with Long COVID are defined based on the duration of symptoms. Group 1 has Long COVID 5–28 weeks after an infection with COVID-19, which is up to the maximum length of Statutory Sick Pay in the UK. Group 2 has symptoms for 29+ weeks, which is beyond the statutory entitlement to sickness pay. Panel regression models are fitted both with fixed-effects and random-effects. Individual and job characteristics are used as controls Those with no COVID-19 symptoms are the reference group.

Results
In between-person comparison, Group 2 is at higher risk of exiting employment compared to those with no COVID-19 symptoms. Between-person estimates of mental health and well-being show negative effects of Long COVID for both groups but these are greatest in Group 2. Within-person estimates suggest that factors associated with earnings mediate the negative Long COVID effects on mental health in Group 1 and that Group 2 adapts to working with Long COVID. Group 1 is at risk of working zero hours (i.e. being on sick leave) but neither Group 1 nor Group 2 have a higher probability of working fewer hours compared to those with no COVID-19 symptoms. The negative impact of Long COVID on working hours stems primarily from working zero hours (sickness leave) rather than working fewer hours, suggesting a lack of accommodation by employers of Long COVID at work.

Policy implications
The extension of Statutory Sickness Pay and greater flexibility to manage partial (returns to) work would help preserve employment and mental health. Those with Long COVID for 12 months are likely to meet the definition of disability and so have a right to receive reasonable workplace adjustments.
Risk of Gastric and Small Intestinal Cancer in Patients With Lynch Syndrome: Data From a Large, Community-Based US Population
Authors: Lin Christina F. , Carwana Holly E. , Jiang Sheng-Fang , Li Dan 
Published: June 2024

INTRODUCTION:
Risk of gastric and small intestinal cancer in Lynch syndrome (LS) remains poorly understood. We investigated the risk of gastric and small intestinal cancer in patients with LS in a large, community-based population.

METHODS:
This retrospective cohort study included all patients diagnosed with LS between January 1, 1997, and December 31, 2020, at Kaiser Permanente Northern California. Cumulative incidence of gastric cancer and small intestinal cancer was calculated using competing risk methodology.

RESULTS:
Among 1,106 patients with LS with a median follow-up of 19.3 years (interquartile range [IQR] 9.4–24.0 years), 11 developed gastric cancer (8 MSH2, 2 MLH1 and 1 PMS2) with a median diagnosis age of 56 years (IQR 42–63 years) and 11 developed small intestinal cancer (6 MSH2, 3 MLH1, 1 MSH6 and 1 PMS2) with a median diagnosis age of 57 years (IQR 50–66 years). Cumulative incidence by age 80 years was 7.26% (95% confidence internal [CI], 1.80–18.03%) for men and 3.43% (95% CI, 0.50–11.71%) for women for gastric cancer and 7.28% (95% CI, 3.19–13.63%) for men and 2.21% (95% CI, 0.23–9.19%) for women for small intestinal cancer. Pathogenic variant carriers of MSH2 and MLH1 had the highest risk of gastric and small intestinal cancer. History of Helicobacter pylori infection was associated with increased risk of gastric cancer (adjusted odds ratio 5.52; 95% CI, 1.72–17.75).

DISCUSSION:
Patients with LS, particularly MSH2 and MLH1 pathogenic variant carriers, had significantly increased lifetime risk of gastric and small intestinal cancer. Testing and treatment of H. pylori infection should be considered for all patients with LS.
Synthesis and stabilization of anatase form of biomimetic TiO2 nanoparticles for enhancing anti-tumor potential
Authors: Mudrakola Sandhya Vidya Sagar , Koopari Chandra Lekha , Kande Ramesh , Rajkumar Karthik , Anoor Pawan Kumar , Burgula Sandeepta , Syed Farhatullah 
Published: June 2024

Abstract
The present study emphasizes the stabilization of the biologically active anatase form of titanium dioxide (TiO2) nanoparticles (NP). TiO2 NP require stringent conditions for chemical synthesis and are usually a mixture of biologically inactive bulk rutile and the active bulk anatase forms. We utilized the culture pellet of the Exiguobacterium aestuarii SBG4 MH185868 to synthesize and stabilize the anatase form of TiO2 NP. The NP showed λ
max at ∼350 nm and scanning electron microscope micrographs indicated their oval and spherical shape. Steric stabilized anatase TiO2 NP exhibited substantial cytotoxicity of up to 80% reduction in cell viability at 100 µg against cervical cancer derived HeLa and SiHa cell lines, whereas the rutile form showed least cytotoxicity. Clonogenic inhibition assay of HeLa cells showed dose-dependent decline with a 75% reduction in colony formation at 100 µg TiO2 NP and cell migration assay revealed significant inhibition in recovery of the wound/scratch in presence of anatase form of TiO2 NP (10–33% at 24 h and 42–79% at 48 h). Co-incubation of HeLa cells with anatase TiO2 NP in chorioallantoic membrane of embryonated chick eggs prevented the formation of new capillaries (20 ± 5% compared with control groups), indicating appreciable anti-angiogenic activity of the NP. Further, TiO2 NP tagged with doxorubicin and paclitaxel exhibited enhanced cytotoxicity against cancer cells at very low concentrations of 9 and 120 nM itself, indicating their anti-tumor potential. In conclusion, biomimetic anatase TiO2 NP have significant anti-proliferative and anti-angiogenic activity and can have potential application in tagging with generic anti-cancer drugs for enhanced cytotoxicity against cancer cells.
On conjugate separability of nilpotent subgroups
Authors: Shahryari Mohammad 
Published: June 2024

Abstract
Let 𝐺 be a group and 𝑘 a positive integer.
We say that 𝐺 is conjugate separable abelian (CSA) if every maximal abelian subgroup of 𝐺 is malnormal.
In this paper, as a natural generalization, we study groups with the property that all maximal nilpotent subgroups of class at most 𝑘 are malnormal, which we refer to as CSN𝑘 groups, and we show that they have many properties in common with the more widely studied CSA groups.
In addition, we introduce the class of nilpotency transitive groups of class 𝑘, denoted NT𝑘, and in the presence of a special residuality condition, we prove that the CSN𝑘 and NT𝑘 properties are equivalent.
Influence of translation on perceived metaphor features: quality, aptness, metaphoricity, and familiarity
Authors: Milenković Katarina , Tasić Miloš , Stamenković Dušan 
Published: June 2024

Abstract
The aim of this study is to examine the effects of translating literary metaphors from Serbian to English on metaphor quality, aptness, metaphoricity, and familiarity. The research involved 55 Serbian metaphors translated into English using the A is B form, which were then evaluated by 252 participants in two separate studies. Study 1 served as an extension of a previous norming study. In it, a group of participants assessed 55 translated literary metaphorical expressions, and their evaluations were compared to those of the original Serbian versions. In Study 2, a group of participants, divided into two subgroups, rated a collection of both the original metaphorical expressions and their translated counterparts. The results indicate that the translated metaphors generally scored higher in terms of aptness, familiarity, quality, and partially in metaphoricity. These findings suggest that translating the metaphors into English had a positive impact on their perceived effectiveness and familiarity. Several factors are considered to explain these outcomes, including the nature of the English language itself, the participants’ exposure to English, and the translation process. Overall, this study highlights the influence of translation on the perception of literary metaphors and provides insights into metaphor interpretation.