bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sinonasal outcomes in obstructive sleep apnea syndrome
Authors: Kuan Edward C. , Tajudeen Bobby A. , Peng Kevin A. , Wang Marilene B. 
Published: June 2015

Objectives/HypothesisObstructive sleep apnea syndrome (OSAS) is a common adult and pediatric sleep disorder, which, if left untreated, is associated with severe medical consequences. Otolaryngologists are often challenged by the impact of OSAS on sinonasal symptoms, as well as by the contribution of primary nasal disorders to exacerbation of OSAS. The objectives of this study are to explore the relationship between patients with known OSAS and quality‐of‐life outcomes as measured by 22‐iem Sino‐Nasal Outcome Test (SNOT‐22) questionnaire scores.Study DesignRetrospective chart review.MethodsPatients with a polysomnographic diagnosis of OSAS completed SNOT‐22 questionnaires. SNOT‐22 questionnaire items were subcategorized into rhinologic, nonrhinologic otolaryngic, sleep, and psychological symptoms. Total, individual, and subcategorized SNOT‐22 scores were correlated with apnea‐hypopnea index (AHI), body mass index (BMI), lowest oxygen desaturation, and sleep efficiency using Spearman rank correlation.ResultsA total of 30 consecutive OSAS patients were included in the analysis. BMI was positively correlated with nonrhinologic otolaryngic symptoms (P = .03), specifically ear fullness (P = .02) and facial pain/pressure (P = .04). AHI was negatively correlated with postnasal drip (P = .02). Lowest oxygen saturation was correlated with reduced productivity (P = .03). Sleep efficiency was negatively correlated with difficulty falling asleep (P = .03) and feelings of frustration (P = .01), with a trend toward significant correlation with overall sleep symptoms (P = .08).ConclusionsSeveral sinonasal complaints appear to be correlated with OSAS severity. As such, otolaryngologists should utilize a comprehensive approach to the care of the OSAS patient, with special attention to sinonasal factors.Level of EvidenceNA Laryngoscope, 125:2617–2620, 2015
Quantitative laryngeal electromyography assessment of cricothyroid function in patients with unilateral vocal fold paralysis
Authors: Fang Tuan‐Jen , Pei Yu‐Cheng , Hsin Li‐Jen , Lin Wan‐Ni , Lee Li‐Ang , Li Hsueh‐Yu , Wong Alice M. K. 
Published: June 2015

Objectives/HypothesisDetermination of superior laryngeal nerve (SLN) involvement in addition to recurrent laryngeal nerve (RLN) paralysis in patients with unilateral vocal fold paralysis (UVFP) relies on traditional, qualitative laryngeal electromyography (LEMG) examination. It is necessary to develop a quantitative measurement that reflects the degree of denervation of the cricothyroid (CT) muscle. The present study aimed to establish a standard quantitative assessment of CT function in patients with UVFP by measuring the turn frequency.Study DesignCase series study performed in an otolaryngology outpatient clinic.MethodsTwenty healthy subjects and 103 patients with UVFP were recruited. The main outcome measures for the patients included acoustic analysis using traditional LEMG examination, quantitative LEMG analysis, and acoustic analysis based on fundamental frequency contours.ResultsAcoustic reliability was examined in the healthy subjects, and the peak fundamental frequency in an upward glissando showed good test–retest reliability, especially for the offset fundamental frequency. LEMG indicated that 33 patients had RLN and SLN lesions (RLN + SLN group) and 70 had only RLN lesions (RLN group). When patients produced a standard upward glissando sound, the peak turn frequency reflecting the recruitment of the CT muscle was significantly lower in the RLN + SLN group compared with the RLN group (406 ± 256 vs. 778 ± 238 Hz; P < .001).ConclusionsWe conclude that quantitative measurement of the interference pattern when voicing a standard upward glissando sound may provide a feasible reflection of the degree of a SLN injury.Level of Evidence4 Laryngoscope, 125:2530–2535, 2015
Effect of environmental factors on Internet searches related to sinusitis
Authors: Willson Thomas J. , Lospinoso Joshua , Weitzel Erik K. , McMains Kevin C. 
Published: June 2015

Objectives/HypothesisSinusitis significantly affects the population of the United States, exacting direct cost and lost productivity. Patients are likely to search the Internet for information related to their health before seeking care by a healthcare professional. Utilizing data generated from these searches may serve as an epidemiologic surrogate.Study DesignA retrospective time series analysis was performed.MethodsGoogle search trend data from the Dallas–Fort Worth metro region for the years 2012 and 2013 were collected from www.google.com/trends for terms related to sinusitis based on literature outlining the most important symptoms for diagnosis. Additional terms were selected based on common English language terms used to describe the disease. Twelve months of data from the same time period and location for common pollutants (nitrogen dioxide, ozone, sulfur dioxide, and particulates), pollen and mold counts, and influenza‐like illness were also collected. Statistical analysis was performed using Pearson correlation coefficients, and potential search activity predictors were assessed using autoregressive integrated moving average.ResultsPearson correlation was strongest between the terms congestion and influenza‐like illness (r = 0.615), and sinus and influenza‐like illness (r = 0.534) and nitrogen dioxide (r = 0.487). Autoregressive integrated moving average analysis revealed ozone, influenza‐like illness, and nitrogen dioxide levels to be potential predictors for sinus pressure searches, with estimates of 0.118, 0.349, and 0.438, respectively. Nitrogen dioxide was also a potential predictor for the terms congestion and sinus, with estimates of 0.191 and 0.272, respectively.ConclusionsGoogle search activity for related terms follow the pattern of seasonal influenza‐like illness and nitrogen dioxide. These data highlight the epidemiologic potential of this novel surveillance method.Level of EvidenceNA Laryngoscope, 125:2447–2450, 2015
Implication of Gypsum Rates to Optimize Hydraulic Conductivity for Variable‐Texture Saline–Sodic Soils Reclamation
Authors: Ahmad Sagheer , Ghafoor Abdul , Akhtar Muhammad E. , Khan Muhammad Z. 
Published: June 2015

AbstractSodium (Na+) dominated soils reduce saturated hydraulic conductivity (Ks) by clay dispersion and plugging pores, while gypsum (CaSO4•2H2O) application counters these properties. However, variable retrieval of texturally different saline–sodic soils with gypsum at soil gypsum requirement (SGR) devised to define its quantity best suited to improve Ks, leach Na+ and salts. This study comprised loamy‐sand (LS), sandy loam (SL), and clay loam (CL) soils with electrical conductivity of saturation extract (ECe) of ~8 dS m−1, sodium adsorption ratio (SAR) of ~44 (mmol L−1)1/2 and exchangeable sodium of ~41%, receiving no gypsum (G0), gypsum at 25% (G25), 50% (G50) and 75% (G75) of SGR. Soils packed in lysimeters were leached with low‐carbonate water [EC at 0·39 dS m−1, SAR at 0·56 (mmol L−1)1/2 and residual sodium carbonate at 0·15 mmolc L−1]. It proved that a rise in gypsum rate amplified Ks of LS ≫ SL > CL. However, Ks of LS soil at G25 and others at G75 remained efficient for salts and Na+ removal. Retention of calcium with magnesium (Ca2+ + Mg2+) by LS and SL soils increased by G50 and decreased in G75, while in CL, it also increased with G75. The enhanced Na+ leaching efficiency in LS soil with G25 was envisaged by water stay for sufficient time to dissolve gypsum and exchange and leach out Na+. Overall, the superiority of gypsum for LS at G25, SL at G50 and CL at G75 predicted cost‐effective soil reclamation with a decrease in ECe and SAR below 0·97 dS m−1 and 5·92 (mmol L−1)1/2, respectively. Copyright © 2015 John Wiley & Sons, Ltd.
On the application of higher‐order elements in the hierarchical interface‐enriched finite element method
Authors: Soghrati Soheil , Barrera Jorge L. 
Published: June 2015

SummaryThis article introduces a new algorithm for evaluating enrichment functions in the higher‐order hierarchical interface‐enriched finite element method (HIFEM), which enables the fully mesh‐independent simulation of multiphase problems with intricate morphologies. The proposed hierarchical enrichment technique can accurately capture gradient discontinuities along materials interfaces that are in close proximity, in contact, and even intersecting with one another using nonconforming finite element meshes for discretizing the problem. We study different approaches for creating higher‐order HIFEM enrichments corresponding to six‐node triangular elements and analyze the advantages and shortcomings of each approach. The preferred method, which yields the lowest computational cost and highest accuracy, relies on a special mapping between the local and global coordinate systems for evaluating enrichment functions. A comprehensive convergence study is presented to show that this method yields similar convergence rate and precision as those of the standard FEM with conforming meshes. Finally, we demonstrate the application of the higher‐order HIFEM for simulating the thermal and deformation responses of several materials systems and engineering problems with complex geometries. Copyright © 2015 John Wiley & Sons, Ltd.
Detection and role of minimal disseminated disease in children with lymphoblastic lymphoma: The AIEOP experience
Authors: Mussolin Lara , Buldini Barbara , Lovisa Federica , Carraro Elisa , Disarò Silvia , Nigro Luca Lo , d'Amore Emanuele S.G. , Pillon Marta , Basso Giuseppe 
Published: June 2015

BackgroundThe use of intensive chemotherapy regimens in children with lymphoblastic lymphoma (LBL) has significantly improved outcome, but the salvage rate for these patients is still poor. The aim of this study was to evaluate the prognostic value of minimal disseminated disease (MDD), studied by multiparametric flow cytometry (MFC), in pediatric patients with T‐ and B‐lineage LBL.ProcedureWe examined bone marrow (BM) and peripheral blood (PB) samples from a series of 65 children affected by T‐ (52) and B‐lineage (13) LBL using an MFC method; 10 of them were also analyzed for clonality of T‐cell receptor gene rearrangements.ResultsMDD was detected in 49% (32/65) of BM samples, whereas only 21% (14/65) were positive at standard morphological evaluation. Findings from MFC analyses of paired BM and PB samples were highly concordant. We analyzed the prognostic significance of MDD results detected at diagnosis in morphologically negative patients, as almost all relapsed cases (10/11) did not have any morphological involvement of BM at diagnosis. Using an MDD cut‐off level of 3% by FCM (75th percentile), 5‐year event‐free survival (EFS) was 60% (SE ± 22) for patients with MDD >3% LBL cells versus 83% (SE ± 6) for the remaining patients (P = 0.04). No statistically significant difference in EFS was observed between LBL patients considering all the other clinical characteristics.ConclusionsOur data demonstrated that MDD studied at diagnosis by MFC could represent a useful prognostic tool in childhood LBL and further application for better stratification is warranted. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Is the Quebec provincial administrative database a valid source for research on chronic non‐cancer pain?
Authors: Lacasse Anaïs , Ware Mark A. , Dorais Marc , Lanctôt Hélène , Choinière Manon 
Published: June 2015

AbstractPurposeThe objective of this study was to evaluate the validity of diagnostic codes recorded in the Régie de l'assurance maladie du Québec (RAMQ) administrative database for identifying patients suffering from various types of chronic non‐cancer pain.MethodsThe validity of published International Classification of Diseases, Ninth Revision, coding algorithms for identifying patients with particular chronic pain syndromes in the RAMQ database was tested using pain specialist‐established diagnostic data of 561 patients enrolled in the Quebec Pain Registry, which was used as the reference standard. Modified versions of these algorithms (i.e., adaptation of the number of healthcare encounters) were also tested. For each algorithm, sensitivity, specificity, positive/negative predictive values, and their respective 95% confidence intervals (95%CI) were calculated.ResultsIn the RAMQ database, some previously published algorithms and modified versions of these algorithms were found to be valid for identifying patients suffering from chronic lumbar pain (sensitivity: 0.65, 95%CI: 0.59–0.71; specificity: 0.83, 95%CI: 0.79–0.87), chronic back pain (sensitivity: 0.70, 95%CI: 0.64–0.76; specificity: 0.73, 95%CI: 0.68–0.78), and chronic neck/back pain (sensitivity: 0.71, 95%CI: 0.65–0.76; specificity: 0.78, 95%CI: 0.72–0.82). Algorithms to identify patients with other types of chronic pain showed low sensitivity: complex regional pain syndrome (≤0.07), fibromyalgia (≤0.42), and neuropathic pain (≤0.39).ConclusionsOur study provides evidence supporting the value of the RAMQ administrative database for conducting research on certain types of chronic pain disorders including back and neck pain. Users should, however, be cautious about the limitations of this database for studying other types of chronic pain syndromes such as complex regional pain syndrome, fibromyalgia, and neuropathic pain. Copyright © 2015 John Wiley & Sons, Ltd.
Alteration of the Helicobacter pylori membrane proteome in response to changes in environmental salt concentration
Authors: Voss Bradley J. , Loh John T. , Hill Salisha , Rose Kristie L. , McDonald W. Hayes , Cover Timothy L. 
Published: June 2015

PurposeHelicobacter pylori infection and a high dietary salt intake are each risk factors for the development of gastric cancer. We hypothesize that changes in environmental salt concentrations lead to alterations in the H. pylori membrane proteome.Experimental designLabel‐free and iTRAQ methods were used to identify H. pylori proteins that change in abundance in response to alterations in environmental salt concentrations. In addition, we biotinylated intact bacteria that were grown under high‐ or low‐salt conditions, and thereby analyzed salt‐induced changes in the abundance of surface‐exposed proteins.ResultsProteins with increased abundance in response to high salt conditions included CagA, the outer membrane protein HopQ, and fibronectin domain‐containing protein HP0746. Proteins with increased abundance in response to low salt conditions included VacA, two VacA‐like proteins (ImaA and FaaA), outer‐membrane iron transporter FecA3, and several proteins involved in flagellar activity. Consistent with the proteomic data, bacteria grown in high salt conditions exhibited decreased motility compared to bacteria grown in lower salt conditions.Conclusion and clinical relevanceAlterations in the H. pylori membrane proteome in response to high salt conditions may contribute to the increased risk of gastric cancer associated with a high salt diet.
Two New Solvent‐modulated Zinc(II) Metal‐Organic Hybrid Materials based on Rigid Tripodal Carboxylate Ligand and 2,2′‐Bipy Co‐ligand: Crystal Structures and Luminescent Properties
Authors: Liu Xiao‐Bin , Xiao Zhen‐Yu , Zhang Ming‐Hui , Zhang Liang‐Liang , Wang Rong‐Ming , Sun Dao‐Feng 
Published: June 2015

AbstractThe zinc(II) coordination polymers [Zn(Htatb)(2,2′‐bipy)·(NMP)·H2O] (1) and [Zn3(tatb)2(2,2′‐bipy)3·H2O] (2) (H3tatb = 4,4′,4′′‐s‐triazine‐2,4,6‐triyl‐tribenzoic acid; 2,2′‐bipy = 2,2′‐bipyridyl, NMP = N‐methyl‐2‐pyrrolidon), were synthesized hydrothermally, and characterized by infrared spectroscopy (IR), powder X‐ray diffraction (PXRD), and single‐crystal X‐ray diffraction. Both compounds 1 and 2 possess expectant low dimensional coordination structures, which further connected into interesting 3D networks by hydrogen bond and strong π–π interactions. Moreover, the thermal stabilities and fluorescent properties of 1 and 2 were investigated.
Mitochondrial trifunctional protein deficiency in human cultured fibroblasts: effects of bezafibrate
Authors: Djouadi Fatima , Habarou Florence , Le Bachelier Carole , Ferdinandusse Sacha , Schlemmer Dimitri , Benoist Jean François , Boutron Audrey , Andresen Brage S. , Visser Gepke , de Lonlay Pascale , Olpin Simon , Fukao Toshiyuki , Yamaguchi Seiji , Strauss Arnold W. , Wanders Ronald J. A. , Bastin Jean 
Published: June 2015

AbstractMitochondrial trifunctional protein (MTP) deficiency caused by HADHA or HADHB gene mutations exhibits substantial molecular, biochemical, and clinical heterogeneity and ranks among the more severe fatty acid oxidation (FAO) disorders, without pharmacological treatment. Since bezafibrate has been shown to potentially correct other FAO disorders in patient cells, we analyzed its effects in 26 MTP‐deficient patient fibroblasts representing 16 genotypes. Overall, the patient cell lines exhibited variable, complex, biochemical profiles and pharmacological responses. HADHA‐deficient fibroblasts showed markedly reduced alpha subunit protein levels together with decreased beta‐subunit abundance, exhibited a −86 to −96 % defect in LCHAD activity, and produced large amounts of C14 and C16 hydroxyacylcarnitines. In control fibroblasts, exposure to bezafibrate (400 μM for 48 h) increased the abundance of HADHA and HADHB mRNAs, immune‐detectable alpha and beta subunit proteins, activities of LCHAD and LCKAT, and stimulated FAO capacities, clearly indicating that MTP is pharmacologically up‐regulated by bezafibrate in human fibroblasts. In MTP‐deficient patient fibroblasts, which were found markedly FAO‐deficient, bezafibrate improved FAO capacities in six of 26 (23 %) cases, including three cell lines heterozygous for the common c1528G > C mutation. Altogether, our results strongly suggest that, due to variable effects of HADHA and HADHB mutations on MTP abundance and residual activity, improvement of MTP deficiency in response to bezafibrate was achieved in a subset of responsive genotypes.
High metabolic tumor volume and total lesion glycolysis are associated with lateral lymph node metastasis in patients with incidentally detected thyroid carcinoma
Authors: Kim Bo Hyun , Kim Seong-Jang , Kim Keunyoung , Kim Heeyoung , Kim So Jung , Kim Won Jin , Jeon Yun Kyung , Kim Sang Soo , Kim Yong Ki , Kim In Joo 
Published: June 2015

Abstract

Objective
The objective of this study was to investigate whether total lesion glycolysis (TLG) and metabolic tumor volume (MTV) measured by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) could predict the aggressiveness and lymph node metastasis (LNM) in patients with incidentally detected differentiated thyroid carcinoma.

Methods
A total 358 patients with focal FDG-avid thyroid incidentaloma during cancer evaluation were enrolled. Among 235 patients in whom fine-needle aspiration biopsy was performed, 51 patients underwent total thyroidectomy with LN dissection. We analyzed the relationship between volume-based parameters and clinicopathologic characteristics.

Results
The mean age and tumor size were 57.1 ± 11.3 years and 1.15 ± 0.81 cm, respectively. The prevalence of malignancy was 21.7 % (51/235). When SUVmax > 5.91, MTV2.5 > 2.05 cm3, and TLG2.5 > 9.09 were used as cutoff points, sensitivity, specificity, and area under curve (AUC) for prediction of lateral LNM were 77.9, 69.1 %, 0.716 (P = 0.047), 77.8, 88.1 %, 0.839 (P < 0.001), 77.8, 85.1 %, and 0.815 (P = 0.002), respectively. However, MTV and TLG had no value in prediction of central LNM, extrathyroidal extension, and multifocality. On comparison ROC curve analysis, the MTV and TLG showed the statistical differences for the prediction of lateral LNM compared with SUVmax (all P’s < 0.05).

Conclusions
This study has shown for the first time that volume-based PET functional parameters had a significant value for the prediction of lateral LNM in incidentally detected PTC. These results suggest that higher MTV and TLG can be potential new risk factors for preoperative risk stratification. The usefulness of TLG and MTV in preoperative risk stratification in patients with PTC needs to be confirmed in further large studies.
Regenerative medicine in otorhinolaryngology
Authors: Wormald J C R , Fishman J M , Juniat S , Tolley N , Birchall M A 
Published: June 2015

AbstractBackground:Tissue engineering using biocompatible scaffolds, with or without cells, can permit surgeons to restore structure and function following tissue resection or in cases of congenital abnormality. Tracheal regeneration has emerged as a spearhead application of these technologies, whilst regenerative therapies are now being developed to treat most other diseases within otolaryngology.Methods and results:A systematic review of the literature was performed using Ovid Medline and Ovid Embase, from database inception to 15 November 2014. A total of 561 papers matched the search criteria, with 76 fulfilling inclusion criteria. Articles were predominantly pre-clinical animal studies, reflecting the current status of research in this field. Several key human research articles were identified and discussed.Conclusion:The main issues facing research in regenerative surgery are translation of animal model work into human models, increasing stem cell availability so it can be used to further research, and development of better facilities to enable implementation of these advances.
A scanning cavity microscope
Authors: Mader Matthias , Reichel Jakob , Hänsch Theodor W. , Hunger David 
Published: June 2015

AbstractImaging the optical properties of individual nanosystems beyond fluorescence can provide a wealth of information. However, the minute signals for absorption and dispersion are challenging to observe, and only specialized techniques requiring sophisticated noise rejection are available. Here we use signal enhancement in a high-finesse scanning optical microcavity to demonstrate ultra-sensitive imaging. Harnessing multiple interactions of probe light with a sample within an optical resonator, we achieve a 1,700-fold signal enhancement compared with diffraction-limited microscopy. We demonstrate quantitative imaging of the extinction cross-section of gold nanoparticles with a sensitivity less than 1 nm2; we show a method to improve the spatial resolution potentially below the diffraction limit by using higher order cavity modes, and we present measurements of the birefringence and extinction contrast of gold nanorods. The demonstrated simultaneous enhancement of absorptive and dispersive signals promises intriguing potential for optical studies of nanomaterials, molecules and biological nanosystems.
Ionic transport in hybrid lead iodide perovskite solar cells
Authors: Eames Christopher , Frost Jarvist M. , Barnes Piers R. F. , O’Regan Brian C. , Walsh Aron , Islam M. Saiful 
Published: June 2015

AbstractSolar cells based on organic–inorganic halide perovskites have recently shown rapidly rising power conversion efficiencies, but exhibit unusual behaviour such as current–voltage hysteresis and a low-frequency giant dielectric response. Ionic transport has been suggested to be an important factor contributing to these effects; however, the chemical origin of this transport and the mobile species are unclear. Here, the activation energies for ionic migration in methylammonium lead iodide (CH3NH3PbI3) are derived from first principles, and are compared with kinetic data extracted from the current–voltage response of a perovskite-based solar cell. We identify the microscopic transport mechanisms, and find facile vacancy-assisted migration of iodide ions with an activation energy of 0.6 eV, in good agreement with the kinetic measurements. The results of this combined computational and experimental study suggest that hybrid halide perovskites are mixed ionic–electronic conductors, a finding that has major implications for solar cell device architectures.