Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia
Authors: Paragomi Pedram , Zhang Zhongjie , Abe Sarah Krull , Islam Md. Rashedul , Rahman Md. Shafiur , Saito Eiko , Shu Xiao-Ou , Dabo Bashir , Pham Yen Thi-Hai , Chen Yu , Gao Yu-Tang , Koh Woon-Puay , Sawada Norie , Malekzadeh Reza , Sakata Ritsu , Hozawa Atsushi , Kim Jeongseon , Kanemura Seiki , Nagata Chisato , You San-Lin , Ito Hidemi , Park Sue K. , Yuan Jian-Min , Pan Wen-Harn , Wen Wanqing , Wang Renwei , Cai Hui , Tsugane Shoichiro , Pourshams Akram , Sugawara Yumi , Wada Keiko , Chen Chien-Jen , Oze Isao , Shin Aesun , Ahsan Habibul , Boffetta Paolo , Chia Kee Seng , Matsuo Keitaro , Qiao You-Lin , Rothman Nathaniel , Zheng Wei , Inoue Manami , Kang Daehee , Luu Hung N. 
Published: August 2024

ImportanceThe global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality.ObjectivesTo assess the association between body mass index (BMI) and risks of incident CRC and CRC-related death in the Asian population.Design, Setting, and ParticipantsThis cohort study includes data pooled from 17 prospective cohort studies included in The Asia Cohort Consortium. Cohort enrollment was conducted from January 1, 1984, to December 31, 2002. Median follow-up time was 15.2 years (IQR, 12.1-19.2 years). Data were analyzed from January 15, 2023, through January 15, 2024.ExposureBody mass index, calculated as weight in kilograms divided by height in meters squared.Main Outcomes and MeasuresThe primary outcomes were CRC incidence and CRC-related mortality. The risk of events is reported as adjusted hazard ratios (AHRs) and 95% CIs for incident CRC and death from CRC using the Cox proportional hazards regression model.ResultsTo assess the risk of incident CRC, 619 981 participants (mean [SD] age, 53.8 [10.1] years; 52.0% female; 11 900 diagnosed incident CRC cases) were included in the study, and to assess CRC-related mortality, 650 195 participants (mean [SD] age, 53.5 [10.2] years; 51.9% female; 4550 identified CRC deaths) were included in the study. A positive association between BMI and risk of CRC was observed among participants with a BMI greater than 25.0 to 27.5 (AHR, 1.09 [95% CI, 1.03-1.16]), greater than 27.5 to 30.0 (AHR, 1.19 [95% CI, 1.11-1.29]), and greater than 30.0 (AHR, 1.32 [95% CI, 1.19-1.46]) compared with those with a BMI greater than 23.0 to 25.0 (P &amp;lt; .001 for trend), and BMI was associated with a greater increase in risk for colon cancer than for rectal cancer. A similar association between BMI and CRC-related death risk was observed among participants with a BMI greater than 27.5 (BMI &amp;gt;27.5-30.0: AHR, 1.18 [95% CI, 1.04-1.34]; BMI &amp;gt;30.0: AHR, 1.38 [95% CI, 1.18-1.62]; P &amp;lt; .001 for trend) and was present among men with a BMI greater than 30.0 (AHR, 1.87 [95% CI, 1.49-2.34]; P &amp;lt; .001 for trend) but not among women (P = .15 for trend) (P = .02 for heterogeneity).Conclusions and RelevanceIn this cohort study that included a pooled analysis of 17 cohort studies comprising participants across Asia, a positive association between BMI and CRC incidence and related mortality was found. The risk was greater among men and participants with colon cancer. These findings may have implications to better understand the burden of obesity on CRC incidence and related deaths in the Asian population.