bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving treatment fidelity: Factors that predict trauma‐focused cognitive behavioral therapy component use
Authors: Korenchuk Jennifer L. , Crockett Stephanie A. , Leibert Todd W. , Anderson Kelli B. 
Published: July 2024

AbstractThis study examined the utilization of trauma‐focused cognitive behavioral therapy (TF‐CBT) treatment components, as well as factors that predicted therapist TF‐CBT component use. Participants were 264 TF‐CBT‐trained mental health therapists. The most frequently used components, as reported by therapists, were affect regulation, relaxation, and psychoeducation about trauma, while the least frequently used were in vivo exposure, conjoint sessions, and caregiver involvement. Results of a hierarchical linear regression indicated that therapist self‐efficacy and child trauma clinical beliefs (i.e., clinical structure and verbal capacity) positively predicted therapist TF‐CBT component use. Perceived barriers to TF‐CBT use negatively predicted therapist TF‐CBT component use. Implications for counseling practice and future research directions are included.
Microdroplet‐assisted protein adduct formation and characterization by mass spectrometry
Authors: Wang Chih‐Hung , Jen Hung‐Hsiang , Chen Fung‐Yu , Liu Kang‐Yu , Chen Shu‐Hui 
Published: July 2024

AbstractThere have been increasing interests in developing proteomics‐based protein adduct detection for monitoring carcinogen exposure risk. Generating adducted protein standards and characterizing the adduction sites by bottom‐up proteomics, however, require lengthy adduction and enzymatic digestion. Here we demonstrated that microdroplet can greatly accelerate the catechol estrogen adduction on hemoglobin (Hb) as well as one‐pot reaction of adduction and enzyme digestion in millisecond for bottom‐up characterization. The adducted Hb generated by microdroplet reaction was characterized to contain one to two catechol estrogens with the β chain of Hb (Hb‐β) by online in situ intact measurement of mass spectrometry. The adduction sites were further identified to be C112‐Hb‐β or C93‐Hb‐β by microdroplet one‐pot or two‐step adduction and digestion. These results were consistent with the intact measurement and also same as the bulk or endogenous reaction. This method is expected to be applicable to prepare protein standards adducted by other reactive oxidizing species to greatly save time and sample amount.
Defective acyclic colorings of planar graphs
Authors: Lo On‐Hei Solomon , Seamone Ben , Zhu Xuding 
Published: July 2024

AbstractThis paper studies two variants of defective acyclic coloring of planar graphs. For a graph and a coloring of , a 2‐colored cycle (2CC) transversal is a subset of that intersects every 2‐colored cycle. Let be a positive integer. We denote by the minimum integer such that has a proper ‐coloring which has a 2CC transversal of size , and by the minimum size of a subset of such that is acyclic ‐colorable. We prove that for any ‐vertex 3‐colorable planar graph and for any planar graph provided that . We show that these upper bounds are sharp: there are infinitely many planar graphs attaining these upper bounds. Moreover, the minimum 2CC transversal can be chosen in such a way that induces a forest. We also prove that for any planar graph and .
Beyond Western Notions of Creativity in Education: Toward a Trans‐Epistemological Approach
Authors: Mehta Rohit , Creely Edwin , Henriksen Danah , Henderson Michael , Crawford Renee 
Published: July 2024

ABSTRACTIn this editorial for the special issue on Beyond Western Notions of Creativity in Education, we provide an overview of six articles that challenge the normative ontological, epistemological, and methodological underpinning of creativity research and practice in education. This special issue aimed to interrogate and problematize the notion of creativity as a Western conception, to expand it toward developing a more global, diverse, inclusive, and decolonized vision. Articles in this issue contribute to a more expanded conception beyond traditional Western ways of knowing and point to new areas for research within existing understandings of creativity. We explore creative practices and conceptualizations, as well as diverse research paradigms beyond Western traditions to present a more holistic understanding. We share implications for future research and practice for educators and scholars interested in expanding beyond the Western conceptualizations of creativity.
Guidelines of the Brazilian Society of Surgical Oncology for anatomopathological, immunohistochemical, and molecular testing in female tumors
Authors: Ribeiro Reitan , Carvalho Filomena Marino , Baiocchi Glauco , Guindalini Rodrigo Santa Cruz , da Cunha Juliano Rodrigues , Anjos Carlos Henrique dos , de Nadai Costa Caroline , Gifoni Ana Carolina Leite Vieira Costa , Neto Renato Cagnacci , Cagnacci Allyne Queiroz Carneiro , Carneiro Vandré Cabral Gomes , Calabrich Aknar , Moretti‐Marques Renato , Pinheiro Rodrigo Nascimento , de Castro Ribeiro Heber Salvador 
Published: July 2024

AbstractIntroductionPrecision medicine has revolutionized oncology, providing more personalized diagnosis, treatment, and monitoring for patients with cancer. In the context of female‐specific tumors, such as breast, ovarian, endometrial, and cervical cancer, proper tissue collection and handling are essential for obtaining tissue, immunohistochemical (IHC), and molecular data to guide therapeutic decisions.ObjectivesTo establish guidelines for the collection and handling of tumor tissue, to enhance the quality of samples for histopathological, IHC, genomic, and molecular analyses. These guidelines are fundamental in informing therapeutic decisions in cancer treatment.MethodThe guidelines were developed by a multidisciplinary panel of renowned specialists between June 12, 2013 and February 12, 2024. Initially, the panel deliberated on critical and controversial topics related to conducting precision medicine studies focusing on female tumors. Subsequently, 22 pivotal topics were identified within the framework and assigned to groups. These groups reviewed relevant literature and drafted preliminary recommendations. Following this, the recommendations were reviewed by the coordinators and received unanimous approval. Finally, the groups made the final adjustments, classified the level of evidence, and ranked the recommendations.ConclusionThe collection of surgical samples requires minimum quality standards to enable histopathological, IHC, genomic, and molecular analyses. These analyses provide crucial data for informing therapeutic decisions, significantly impacting potential survival gains for patients with female tumors.
Contribution of Musculoskeletal Ultrasound in the Diagnosis of Seronegative Rheumatoid Arthritis
Authors: Cen Yang , He Danqing , Wang Peiyao , Qin Yangyang , Huang Meng 
Published: July 2024

ObjectiveThis is a study to investigate the value of musculoskeletal ultrasound for the early diagnosis of seronegative rheumatoid arthritis (SNRA); and to study the relationship between anti‐cyclic citrullinated peptide antibody (anti‐CCP) and the occurrence of bone erosion in rheumatoid arthritis (RA) detected by ultrasound.MethodsA total of 101 patients with RA or osteoarthritis (OA) admitted to the First Affiliated Hospital of Anhui Medical University from July 2022 to December 2023 were selected and divided into the SNRA group, the SPRA group, and the OA group. The patients' metacarpophalangeal joints, proximal interphalangeal joints, distal interphalangeal joints, and wrist joints of both hands were ultrasonically examined separately, and the extensor tendon, flexor tendon, synovium, joint surface, joint cavity, and bone surface were observed.ResultsThe differences in the detection of joint effusion, bone erosion, and joint space narrowing were not statistically significant between SNRA group and OA group (P > .05), the differences in the detection of synovitis and tenosynovitis were statistically significant (P < .05). The mean levels of synovial hyperplasia grade and synovial blood flow grade between SNRA group and OA group were significantly different (P < .05). The differences in synovitis, tenosynovitis, joint effusion, and joint space narrowing were not statistically significant between SNRA and SPRA groups (P > .05), and the differences in bone erosion were statistically significant (P < .05). The mean levels of synovial hyperplasia grade and synovial blood flow grade between SNRA group and SPRA group were significantly different (P < .05). Logistic regression analysis showed that anti‐CCP antibody was an influential factor for bone erosion in RA patients (P < .05). The ROC curve was plotted, and the optimal cut‐off value of anti‐CCP antibody was 356.5 U/mL, at which time the AUC was 0.716, the sensitivity of diagnosing bone erosion was 0.714, the specificity was 0.694, and the Yoden index was 0.408.ConclusionIn summary, ultrasound is helpful for the early diagnosis of SNRA by evaluating the condition of joints, synovium, and tendon sheath, and when anti‐CCP antibodies are positive, ultrasound is more likely to detect bone erosion. Ultrasound examination combined with anti‐CCP antibody can further observe the joint lesions.
Influencing factors of particle deposition in the human nasal cavity
Authors: Guo Yingke , Tang Yuanyuan , Su Yingfeng , Sun Dong 
Published: July 2024

AbstractObjectiveTo review the existing literature on the application of computational fluid dynamics methods to study nasal particle deposition and to summarize and analyze the factors affecting nasal particle deposition in order to provide theoretical references for the development of future transnasal drug delivery devices and the prevention of respiratory‐related diseases.Data SourcePubMed and CNKI databases.MethodsA search of all current literature (up to and including February 2023) was conducted. Search terms related to the topic of factors influencing nasal particle deposition were identified, and queries were conducted to identify relevant articles.ResultsBoth the properties of the particles themselves and the environmental conditions external to the particles can affect particle deposition in the nasal cavity, with particle deposition showing a positive correlation with particle size, particle density, and airflow velocity, with increasing subject age leading to a decrease in deposition, and with the relationship between airflow temperature and humidity still requiring more research to further explore.ConclusionsWith the popularity of computational fluid dynamics, more and more scholars have applied computational fluid dynamics technology to explore the influence of different parameters on particle deposition. By summarizing and analyzing the influence law of various factors on deposition, it can provide a theoretical basis for the future development and application of transnasal drug delivery devices and the prevention of respiratory‐related diseases, which makes a significant contribution to the optimization of clinical disease prevention and treatment.Level of EvidenceNA.
Zooplankton grazing reduces the persistence of an anthropogenic pollution marker in lake water
Authors: Borgomaneiro Giulia , Di Cesare Andrea , Callieri Cristiana , Corno Gianluca , Fontaneto Diego , Piscia Roberta , Eckert Ester M. 
Published: July 2024

AbstractWastewater treatment plant effluents release microbiological pollutants, including the intI1 gene (integrases of class 1 integron), which has been proposed as a target for monitoring anthropogenic pollution in surface waters. This gene correlates with antibiotic resistance genes, making it an important proxy for genetic contamination in aquatic environments. It is currently unclear whether intI1 found in lake water is mainly present due to continuous seeding or if autochthonous bacteria harbor this gene. To better understand the fate and dynamics of class 1 integrons in aquatic systems, we resorted to classical limnological monitoring of intI1 (qPCR) over multiple years in three different size fractions: free‐living bacteria, particle‐attached bacteria, and zooplankton‐attached bacteria. We also conducted experiments to elucidate the impact of grazers on the abundance of intI1. The monitoring of different size fractions of the Lake Maggiore microbial community showed a particle‐bound lifestyle for intI1‐hosting bacteria. Most of these bacteria originated from both a wastewater effluent that discharges into Lake Maggiore and the lake water itself (amplicon sequencing). We hypothesize that these bacteria grow on particles in open waters, making them particularly vulnerable to grazing by large filter feeders such as Daphnia. Therefore, the presence of Daphnia reduced the abundance of intI1 in lake water, whereas this was not true for other grazers such as Rotaria macrura or Poterioochromonas sp. Our study shows that the food web structure and temporal changes in the lake influence the abundance of intI1 and consequently the assessment of anthropogenic pollution.
Dynamic Information Encryption and Coding using Liquid Crystal Soft Helical Microstructures with Spiropyran Photochromic Switch
Authors: Qu Guangyin , Zhang Xiaojuan , Li Siqi , Kuai Yan , Xu Feng , Lu Liang , Liu Yu , Cao Zhigang , Yu Benli , Gomes Anderson S. L. , Hu Zhijia 
Published: July 2024

AbstractIn contrast to conventional anti‐counterfeiting technologies, which are susceptible to decryption and exhibit limited effectiveness, the utilization of light to dynamically configure soft materials in a fully reversible and programmable manner not only enhances data security but also improves anti‐counterfeiting performance. However, achieving precise control over reflection structural colors and laser wavelengths within a broad dynamic range remains a challenge. In this study, a UV‐responsive soft helical superstructure is established by combining a photochromic compound with chiral liquid crystals (LCs). By manipulating the Bragg reflection angle, structural reflection colors ranging from red to cyan are successfully achieved. The introduction of an anti‐counterfeiting technique that embeds diverse micro‐structures provides features such as color adjustability, erasability, and angle‐dependent stability. Using the unique properties of this soft helical superstructure, the implementation of a wavelength‐tunable LC bandgap laser through optically reconfigurable Förster resonance energy transfer processes is showcased. Furthermore, a straightforward prototype information encoder is developed to mimic the processes of information encoding and decoding, bypassing the need for complex algorithm design. This research underscores the practicality of LC helical soft systems, emphasizing their distinctive responsiveness to light and their applicability in optical programming photonics.
Mutated neuron navigator 3 as a candidate gene for a rare neurodevelopmental disorder
Authors: Umair Muhammad , Alharbi Meshael , Aloyouni Essra , Al Abdulrahman Abdulkareem , Aldrees Mohammed , Al Tuwaijri Abeer , Bilal Muhammad , Alfadhel Majid 
Published: July 2024

AbstractBackgroundNeuron navigator 3 (NAV3) is characterized as one of the neuron navigator family (NAV1, NAV2, NAV3) proteins predominantly expressed in the nervous system. The NAV3‐encoded protein comprises a conserved AAA and coiled‐coil domains characteristic of ATPases, which are associated with different cellular activities.MethodsWe describe a Saudi proband presenting a complex recessive neurodevelopmental disorder (NDD). Whole exome sequencing (WES) followed by Sanger sequencing, 3D protein modeling and RT‐qPCR was performed.ResultsWES revealed a bi‐allelic frameshift variant (c.2604_2605delAG; p.Val870SerfsTer12) in exon 12 of the NAV3 gene. Furthermore, RT‐qPCR revealed a significant decrease in the NAV3 mRNA expression in the patient sample, and 3D protein modeling revealed disruption of the overall secondary structure.ConclusionFor the time, we associate a bi‐allelic variant in the NAV3 gene causing NDD in humans.
Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting
Authors: Shawky Lamiaa M. , Abo El Wafa Sahar M. , Behery Maged , Bahr Mohamed H. , Abu Alnasr Mahmoud Tawfiq , Morsi Ahmed A. 
Published: July 2024

ScopeDiarrhea is a common health issue that contributes to a significant annual death rate among children and the elderly worldwide. The anti‐diarrheal activity of Lactobacillus rhamnosus GG (LGG) and tannic acid (TA), alone or combined, is examined, in addition to their effect on intestinal barrier integrity.Methods and resultsFifty‐six adult male Wistar rats are randomly assigned into seven groups: control, LGG alone, TA alone, diarrhea model, diarrhea+LGG, diarrhea+TA, and diarrhea+LGG+TA‐treated groups. Diarrhea is induced by high‐lactose diet (HLD) consumption. LGG (1x109 CFU/rat) and TA (100 mg Kg−1 d−1) were given orally 4 days after HLD feeding and continued for 10 days. Ileum specimens are processed for biochemical analysis of the local intestinal cytokines, polymerase chain reaction (PCR), and histological study. Also, immunohistochemistry‐based identification of Proliferating Cell Nuclear Antigen (PCNA) and zonula occludens 1 (ZO‐1) is performed. Compared to the diarrhea model group, both treatments maintain the intestinal mucosal structure and proliferative activity and preserve ZO‐1 expression, with the combination group showing the maximal effect. However, LGG‐treated diarrheic rats show a remarkable decrease in the intestinal tissue concentrations of tumor necrosis factor‐alpha (TNF‐α) and nuclear factor Kappa beta (NF‐κB); meanwhile, TA treatment leads to a selective decrease of interferon‐gamma (INF‐γ) and transforming growth factor‐beta (TGF‐β1).ConclusionIndividual LGG and TA treatments significantly alleviate diarrhea, probably through a selective immunomodulatory cytokine‐dependent mechanism, while the combination of both synergistically maintains the intestinal mucosa by keeping the intestinal epithelial barrier function and regenerative capability.
The myth of high‐resolution liquid phase biological electron microscopy
Authors: Egelman Edward H. 
Published: July 2024

AbstractCryo‐electron microscopy (cryo‐EM) has transformed structural biology over the past 12 years, with it now being routine rather than exceptional to reach a near‐atomic level of resolution for proteins and macromolecular complexes. Samples are immobilized by vitrification and this sample can be maintained at liquid nitrogen temperatures in the vacuum of the electron microscope with negligible sublimation. Due to the low electron doses needed to avoid radiation damage, averaging over tens of thousands to hundreds of thousands of particle images is used to achieve a high signal‐to‐noise ratio. An alternative approach has been proposed where samples are at room temperature in the liquid state, maintained in the vacuum of the electron microscope by thin film enclosures that are relatively transparent to electrons while preventing evaporation of the liquid. A paper has argued that using this liquid‐phase approach, higher resolution (3.2 Å) can be achieved than using cryo‐EM (3.4 Å) when imaging and reconstructing adeno‐associated virus particles. I show here that these assertions are untrue, and that basic principles in mathematics and physics would need to be violated to achieve the stated resolution in the liquid state. Thus, high resolution liquid phase EM of macromolecules remains science fiction.
Treatment of Sinonasal Teratocarcinosarcoma: A case report
Authors: Yang Gang , Wang Xiaoshen 
Published: July 2024

AbstractSinonasal teratocarcinosarcoma (SNTCS) is a rare malignancy characterized by a highly aggressive nature. It mainly arises in the ethmoidal or maxillary sinus. SNTCS has a poor prognosis, with a mean survival rate of 55% at 2 years. Herein, we presented a case of advanced SNTCS successfully treated with surgery followed by chemoradiotherapy plus targeted therapy and reviewed the published literature on this rare entity.
A momentum budget study of the semi‐annual oscillation in the Whole Atmosphere Community Climate Model
Authors: Jaison Aleena M. , Gray Lesley J. , Osprey Scott , Smith Anne K. , Garcia Rolando R. 
Published: July 2024

AbstractThe representation of the semi‐annual oscillation (SAO) in climate models shows a common easterly bias of several tens of metres per second compared to observations. These biases could be due to deficiencies in eastward tropical wave forcing, the position or strength of the climatological summertime jet or the strength/timing of the Brewer–Dobson circulation. This motivates further analysis of the momentum budget of the upper stratosphere within models and a more detailed comparison with reanalyses to determine the origin of the bias. In this study, the transformed Eulerian mean momentum equation is used to evaluate the different forcing terms that contribute to the SAO in the MERRA2 reanalysis dataset. This is then compared with the equivalent analysis using data from a climate simulation of the Whole Atmosphere Community Climate Model (WACCM). The comparison shows that WACCM underestimates eastward forcing by both resolved and parameterised waves at equatorial latitudes when compared with MERRA2 and also has a weaker tropical upwelling above 1 hPa.
Model two states dynamics of photo‐detachment [F‐H‐F]− induced by an optimally designed polychromatic field
Authors: Seal Dipayan , Sen Shrabani , Chaudhury Pinaki , Ghosh Subhasree 
Published: July 2024

AbstractPhoto‐detachment of electron from [F‐H‐F] to generate neutral [F‐H‐F] has been studied in this article. Neutral has a linear structure and this is the transition state (T.S.) of F + HF FH + F reaction. The Potential Energy Surface (P.E.S.) of neutral [F‐H‐F] and molecular anion [F‐H‐F] for the asymmetric stretching mode is generated and the dynamics under the influence of an external polychromatic field is followed. The P.E.S. of [F‐H‐F] looks like a “flat‐bed” single well where as for [F‐H‐F] it has a symmetrical double well structure. In absence of any external field these two surfaces are well separated. But in presence of external field transition from molecular anion [F‐H‐F]
to neutral molecule [F‐H‐F] takes place which causes the detachment of an electron. We have designed an optimal designed field using Simulated Annealing and studied the dynamics of electron detachment by such external fields. We have achieved detachment probability of by applying the optically designed field.
Effect of Solvothermal Time to Characteristics and Performance of Photocatalyst Bismuth‐Rich Oxyiodide for Dye Decolorization
Authors: Astuti Yayuk , Mawaddah Fidya Azahro Nur , Darmawan Adi , Arnelli  , Suseno Ahmad 
Published: July 2024

AbstractThis study aims to explore how altering solvothermal duration influences the characteristics of the resulting products, spanning crystal structure, band gap energy, morphology, and photocatalytic performance. Bismuth‐rich oxyiodide was synthesized via the solvothermal method by dissolving Bi(NO3)3 ⋅ 5H2O and KI in ethylene glycol. The mixture underwent heating in a Teflon autoclave stainless steel at 120 °C for durations of 6, 12, 24, and 48 hours. Analysis using FTIR revealed the presence of Bi−O and I−O bonds. Diffractograms indicated that all products exhibited traits of Bi4O5I2, with slight traces of Bi5O7I. Distinct band gap energies were observed across the solvothermal durations: 2 eV for 6 hours, 2.08 eV for 12 hours, and 1.89 eV for both 24 and 48 hours, delineating temporal nuances in product properties. Noteworthy, the morphology of the 12 hour variant revealed surface pores, indicative of intricate structural features. Notably, the 12 hour product exhibited the pinnacle of photocatalytic efficacy in methyl orange decolorization under UV light. Furthermore, investigations into photocatalyst mass variations and the inclusion of additional dyes, such as rhemazol black B, further elucidated the robust photocatalytic potential inherent in the B12 variant.