bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Sick Euthyroid Syndrome and Poor Prognosis in Severe Burn Patient
Authors: Salah Afify Galal Abo Elsoud , Tharwat Sayed Ayman Ibrahim , Abdel Hafiez Mohamed Rania Hassan , Mostafa Ali Nahla Ahmed 
Published: July 2024

Abstract

Background
Euthyroid sick syndrome (also known as non-thyroidal illness syndrome) can be described as abnormal findings on thyroid function tests that occur in the setting of a non-thyroidal illness (NTI), without preexisting hypothalamic-pituitary and thyroid gland dysfunction. After recovery from an NTI, these thyroid function test result abnormalities should be completely reversible, study of euthyroid sick syndrome in burn patients.

Aim of the Work
The aim of study is to examine the ability of Euthyroid sick syndrome in predicting prognosis in severe burn patients.

Patients and Methods
A case control study was conducted in burn ICU in Ain Shams University Hospitals from march 2022 to September 2022,88 patients were admitted to study with 44 burn case with ESS and 44 burn case without ESS according to inclusion and exclusion criteria.

Results
The results showed that the group with ESS are more associated with higher rate of morality, hospital stay and more poor prognosis with worse APACHE score levels compared to the burn group with ESS. The study showed that using APACHE score with T3 levels measurements are more accurate in detecting morality in burn ICU patient.

Conclusion
The study demonstrated that ESS are more associated with higher rate of morality, hospital stay and more poor prognosis with worse APACHE score levels.
Peri-Operative Use of Ketamine Infusion versus Dexmedetomidine Infusion for Analgesia in Obese Patients Undergoing Bariatric Surgery: A Double-Blinded Three-Armed Randomized Controlled Trial
Authors: Mahfouz Khalil Belal Nabil , Hussein Elderh Maha Sadek , Rasoul Khaja Mohamed Abdel , El-Shaer Ahmed Nagah , Hassan Ali Bahaa El-Din Ewees , Awad Taeimah Mohamed Osman 
Published: July 2024

Abstract

Background
The development of different techniques in bariatric surgeries has required the development of novel anesthetic techniques to reduce the incidence of complications and improve post-operative patient outcomes. Ketamine and dexmedetomidine have been used for their peri-operative analgesic profiles in different studies.

Methods
Ninety patients were studied and randomized equally into three groups. The Ketamine group received a bolus dose (0.3 mg/kg) of ketamine over 10 min followed by an infusion (0.3 mg/kg/h). The Dexmedetomidine group received a bolus dose (0.5 mcg/kg) of dexmedetomidine over 10 min followed by an infusion (0.5 mcg/kg/h). The control group received normal saline infusion. The total morphine dose was the primary outcome, and intra-operative fentanyl requirements, time to extubation, post-operative nausea and vomiting (PONV), Numerical Rating Scale (NRS) scores, and Modified Observer’s Agitation/Sedation Scale (MOASS) scores were secondary outcomes of the study.

Results
The Dexmedetomidine group showed decreased intra-operative fentanyl requirements (160.000 ± 42.345 µcg), less time to extubation (3.700 ± 0.925 min), and better scores on MOASS than the other groups. Post-operative NRS scores and the morphine requirement in the Ketamine group (1.867 ± 2.921 mg) were lower than in the other groups. The Dexmedetomidine group showed the lowest scores for PONV.

Conclusions
The Dexmedetomidine group showed lower total fentanyl doses, a significantly shorter time to extubation, better MOASS scores, and lower PONV. The Ketamine group showed significantly lower NRS scores and morphine doses than the other two groups. Dexmedetomidine was effective on the reduction of intraoperative fentanyl requirement with early extubation, and ketamine was effective on the reduction of postoperative pain.

Trial Registration
This trial has been registered on clinicaltrials.gov registry (NCT04576975) since 06/10/2020.
Predicting and Measuring Fluid Responsiveness by Hemodynamic Indices versus Transthoracic Echocardiography in Clinically Shocked Patients
Authors: Nour Eldin Bassel M , Said Sherif G , Michael Hany V , Ghatas Basem G 
Published: July 2024

Abstract

Background
In the last decades dynamic measures had evolved as a better solution to predict fluid responsiveness in clinically shocked patients, out of multiple dynamic parameters we chose transthoracic echocardiographic based measurements of variations of aortic blood flow and inferior vena caval diameter.

Aim of the Work
to assess accuracy of transthoracic echo measured variation in aortic blood flow and inferior vena caval diameter with limited bolus crystalloid infusion in predicting fluid responsiveness in patients with clinical shock.

Patients and Methods
This study included 51 selected Patients with acute circulatory failure secondary to clinical shock admitted to ICU. All patients had undergone basic transthoracic echocardiographic (TTE) assessment of aortic blood flow (using left ventricular outflow tract velocity time integral as a surrogate) and inferior vena caval diameter changes with respiratory cycle, these measures were obtained at time of diagnosis of shock and repeated after infusion of 300 ml crystalloid fluid bolus (over fifteen minutes).

Results
Our results had revealed significant difference between responders and non-responders regarding aortic flow variation after fifteen minutes.

Conclusion
Based on the results obtained in this study, it was proved that transthoracic echocardiography can be used as an accurate method to predict fluid responsiveness in shocked patient with fluid challenge.
Comparison of Ultrasound Guided Quadratus Lamborum Plane Block versus Intraperitoneal and Port Sites Bupivacaine Infiltration in Post Operative Analgesia after Laparoscopic Cholecystectomy
Authors: Ibrahim Sherif Farouk , Saleh Mostafa Ashraf Nabil , Hilal Abdou Amr Mohammed , Sayed Yasmeen Abdel-Hamed 
Published: July 2024

Abstract

Background
Poorly controlled acute pain after abdominal surgery is associated with a variety of unwanted postoperative consequences, including patient suffering, distress, respiratory complications, delirium, myocardial ischemia, prolonged hospital stay and an increased likelihood of chronic pain.

Aim of the Work
The aim of this study is to assess the postoperative analgesic efficacy of quadratus lamborum plain block compared to intraperitoneal and periportal infiltration with bupivacaine after laparoscopic cholecystectomy regarding the pain relief, effect on hemodynamics, requirement of first supplemental doses of analgesia and total number of doses received.

Patients and Methods
The study was conducted on 70 randomly chosen patients aged 20 to 60 years, American Society of Anesthesiologists (ASA) class I or II scheduled for elective laparoscopic cholecystectomy in Ain Shams University Hospitals after approval of the medical ethical committee. They were allocated in two groups of 35 patients each: QL block Group, intraperitoneal and periportal infiltration Group:

Results
Patients receiving QL block had significantly lower pain scores at rest for 6 hrs and decrease total need of analgesic in first 24 h post operative compared with patients who received Intraperitoneal and port sites infiltration.

Conclusion
Quadratus Lumborum block was effective in reducing postoperative pain scores for 6 hours and lower total 24 hrs postoperative opioid and analgesic consumption after laparoscopic cholecystectomy under general anesthesia, compared to intraperitoneal and port sites infiltration. This technique can be a promising mode of postoperative analgesia where epidural catheter insertion is contraindicated.
Awareness of Food, Supplement, and Drug Interactions among Oncology Patients on Oral Chemotherapy
Authors: Abdelsamie Ghada , Noureldine Ahmed , Elsayed Zeinab , Abdelaziz Khaled 
Published: July 2024

Abstract

Background
Food-drug interactions (FDIs) are very common, but under-reported due to a lack of proper history or lack of knowledge and limited research. Our study highlights the knowledge gap among oncology patients treated with capecitabine regarding food-oral chemotherapy interactions.

Method
A cross-sectional study was conducted among 110 breast and colon cancer patients, purposively sampled from the chemotherapy outpatient clinic from June 2021 to December 2021. A structured questionnaire and interviews were used to collect data, we asked them about the information they had received from the doctor and the way they were taking the medicine. Data were analyzed using SPSS, and the p-value of p &lt; 0.05 was considered significant.

Results
Regarding the sociodemographic and clinical data of participants, their ages widely ranged from 20-83 years old, and their mean age was 54.78±13.18. The majority of participants were females 81(73.6%), non-employed 86(78.2%), colon cancer 72(65.5%) and received ≤4 cycles 66 (60%). Still, there is poor awareness concerning FDI among oncology patients and most participants were unaware of the possible interactions of capecitabine with grapefruits, vitamins, herbs, and antioxidants, but the majority 92 (83.6%) were taking their medication correctly concerning meal recommendations and only 18(16.4% )were not taking capecitabine within 30 minutes of meals. The current study showed that patients’ knowledge was not associated with age, sex, education, marital status, or occupation. The main factors that affected knowledge in the current study were the cancer site and the number of treatment cycles, as colon cancer patients and those who have received four or fewer cycles had better doctor-patient communication.

Conclusion
There is a lack of awareness about interactions between oral chemotherapy and various nutrients and supplements among patients in the current study. Patient education and better doctor-patient communication are recommended to ensure optimal oral chemotherapy intake and patient safety.
Bilateral Erector Spinae Plane Block versus Oblique Subcostal Transversus Abdominal Plane Block for Postoperative Analgesia of Adults Patients Undergoing Laparoscopic Cholecystectomy
Authors: Soliman Yassa Marco Ashraf , Eldin Nooh Nehal Gamal , Hefny Taha Sameh Salem , Elkomos Saman Poula Michael 
Published: July 2024

Abstract

Background
Nerve root or myofascial irritation at the abdominal wall is a common cause of pain following surgeries such as cholecystectomy, cesarean section, prostatectomy, hysterectomy and transplant surgery.

Aim of the Work
to test the efficacy of ultrasound guided bilateral erector spinae plane block versus ultrasound guided bilateral oblique subcostal tap block as regards its efficacy, hemodynamic stability, onset of post-operative pain, amount of post-operative narcotics used.

Patients and Methods
In the current study fifty eight patients scheduled for elective laparoscopic cholecystectomy received general anesthesia were included. Patients were divided randomly into two groups, each group consisted 29 patients. Group A: Patients in this group received bilateral US guided ESP block at the end of surgery. Group B: Patients in this group received bilateral US guided OSTAP block at the end of surgery.

Results
As regard the analgesic parameters recorded; in the current study, the VAS was significantly lower in group A (ESP block) when compared with that of group B (OSTAP block) and showed significant difference between both groups at 6,8 and 10hrs postoperatively. Also, time to rescue analgesia, there was clinically and statistically highly significant longer time to 1st rescue analgesic in group A (ESP block) was 15.25±1.50 hours compared to that of group B (OSTAP) was 9.86±2.01 hours These findings were in an array with a case series done by Luis-Navarro and his colleagues who reported that the first rescue analgesic was required only at 16 hours after ESP block. In the current study, total morphine consumption “mg” with the mean total consumption in each of Group was 4.45±0.42 mg in the ESP group compared with 5.44±0.37 mg in the OSTAP group there was highly statistically significant higher mean of total analgesic consumption in group B compared to Group A.

Conclusion
bilateral ultrasound-guided ESP block provides more potent and longer postoperative analgesia with less morphine consumption than OSTAP block after laparoscopic cholecystectomy
Patient Self-Proning with High-Flow Nasal Cannula Improves Oxygenation in ARDS Patients: A Randomized Clinical Trial
Authors: Mahmoud Mohamed Sidky , Abdallah ElGendy Hanaa Mohamed , Youssri Mahmoud Noura M , Aly ElGendy MohamedAbd Elsalam , Nassar Nasrallah Beshoy Zarief 
Published: July 2024

Abstract

Background
Acute respiratory distress syndrome is a severe lung disease caused by a variety of direct and indirect insults. It is characterized by acute onset of tachypnea, hypoxemia, and loss of lung compliance. Significant atelectasis is also frequently present. It is associated with increased length of stay in the intensive care unit (ICU), long hospital stay, higher hospital charges as well as increased morbidity and mortality. However, it can be treated if dealt with promptly.

Objective
This work aims to evaluate the effect of self-proning with a high-flow nasal cannula in patients with ARDS on oxygenation and incidence of intubation.

Results
High flow nasal cannula and Proning was effective in improving oxygenation of the mild ARDS patients and decreasing the incidence of intubation (11 patients intubated in group 1, 4 in group 2), mortality(35 survived in group 1,42 in group 2) and ICU stay in these patients.

Conclusions
HFNC AND PRONING succeeded in prophylaxis against intubation in mild ARDS patients in ICU. And they succeeded in decreasing ICU stay days and improving the outcome of mild ARDS patients.

Example
Trial registration: PACTR202204746577792. Registered 14 April 2022 - Retrospectively registered, http://www.pactr.org/PACTR202204746577792
Use of Corticosteroids on Prophylaxis of New-Onset Atrial Fibrillation after Cardiac Surgery
Authors: Abdelsattar Mohamed , Radwan Abdelrahman , Nashed Sherif Wadie , Elagamy Ashraf Elsayed , Hesham Elshaer Eman Mohamed 
Published: July 2024

Abstract

Background
Most cardiac operations are performed under cardiopulmonary bypass(CPB); however, it is well known that cardiopulmonary bypass often causes systemic inflammatory response syndrome (SIRS). Cardiac tissue inflammation induced by the CPB and surgical trauma has been previously hypothesized to cause POAF. The relationship between inflammation and atrial fibrillation after cardiac surgery is further strengthened by studies that showed that corticosteroid (CS) prophylaxis can reduce the occurrence of atrial fibrillation after cardiac surgery.

Aim of the Work
to determine the efficacy of corticosteroids in prophylaxis of POAF and shorten length of intensive care unit (ICU) and hospital stay.

Patients and Methods
This is randomized controlled clinical trial on 84 patients who underwent their first elective cardiac surgery under cardiopulmonary bypass in Ain Shams University Hospitals. Patients were randomized into two equal groups (n = 42 each) as the control group who underwent a standard cardiopulmonary bypass without any additional medication which was performed under the supervision of a specialized elite and experts in their specialization, and the Methylprednisolone (MP) group who was given 1 g of methylprednisolone (divided into 250 mg every 6h once in the ICU), The primary outcome is the overall occurrence of postoperative AF during the first 72 hours after cardiac surgery. Secondary outcomes are the length of hospital stay, and intensive care unit (ICU) stay.

Results
This study revealed that using corticosteroids effective in reducing the incidence of POAF without increasing the incidence of postoperative complications and adverse effects due to corticosteroids therapy. This study showed decreased risk of developing AF in patients undergoing cardiac surgery. The incidence of POAF was found be significant lower in MP group 16.7% (7 patients developed AF) versus 35.7% in the control group (15 patients developed AF) (p 0.047).

Conclusion
Use of Corticosteroids is effective in prophylaxis of POAF in patients undergoing elective cardiac surgery in terms of reducing its incidence and decreasing the length of ICU and hospital stay.
CHA2DS2-VASc Score is a Predictor of No-Reflow in Patients with ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Intervention
Authors: Eldin Hossam Shams , Farag Nabil , Salam Ahmed Abdel , Eletriby Shehab 
Published: July 2024

Abstract

Background
regardless of the magnitude of the infarction, no-reflow is a source of numerous problems, including heart failure, stroke, and death. The CHA2DS2-VASc score is a combination of many risk variables for thromboembolic lesions, the most serious consequences of atrial fibrillation. Current guidelines propose using the CHA2DS2-VASc risk score to estimate thromboembolic events in individuals with atrial fibrillation. It has been demonstrated to be a predictor of problems following acute coronary crises.

Aim of the Work
to assess the role of CHA2DS2-VASc score in prediction of the no-reflow among patients with ST-segment elevation myocardial infarction (STEMI) who was treated with primary PCI.

Subjects and Methods
this is a prospective observational study which was done at cardiology department of Ain Shams University on 300 patients.

Results
the most frequent factor was female sex (43.7%), followed by Diabetes mellitus (27.0%) according to CHA2DS2-VASc score. CHA2DS2-VASc score items statistically were significantly more frequent in no reflow cases except Age ≥75. CHA2DS2-VASc score and its modification significantly had low diagnostic performance in predicting no reflow. Modified was higher than original.

Conclusion
all CHA2DS2-VASC items were proved to be factors affecting no reflow occurrence in the Egyptian population except Age ≥75 and congestive heart failure due to their low prevalence. The CHA2DS2-VASC score had no high diagnostic characteristics in Egyptian population, the postulated modification of CHA2DS2-VASC score gave no better diagnostic characteristics.
Fibromyalgia in Patients with Obstructive Sleep Apnea Patients
Authors: Elsayed Galal Iman Hassan , El-Zohiery Abeer , Ahmed ElBagalaty Mohamed Fathi , Hasan Madbouly Hassnaa Abdelmomen 
Published: July 2024

Abstract

Background
Obstructive sleep apnea (OSA) and Fibromyalgia (FM) concomitantly form an extremely important association because in addition to its adverse effects on the quality of life, it contributes to the mortality rates. Studies evaluating the relationship between OSA, and FM have been conducted in very small patient groups. However, the results are controversial. In our study we aimed to investigate the prevalence of fibromyalgia in obstructive sleep apnea patients because of the similarities between the symptoms of FM and OSA.

Methods
This cross-sectional study was conducted upon 49 patients already diagnosed with OSA. Patients were recruited from the sleep lab of chest department Ain Shams university Hospitals in the period between August 2021 and August 2022. Overnight diagnostic PSG was performed to all patients Then we tested widespread pain index (WPI) and system severity scale (sss) on patients who have OSA by PSG to diagnose FM. The following investigations were done for patients who were suspected of having secondary fibromyalgia: Hepatitis C virus antibodies, Vitamin D level, Complete blood count, Thyroid functions, C-reactive protein, Erythrocyte sedimentation rate and Autoimmune markers.

Results
Out of 49 patients; 10.2% (5 patients) were fibromyalgia positive using WPI and SSS, and all of them had Secondary FM. The only significant negative correlation was observed between SSS score and REM latency (r: -0.370, P-value: 0.009). All other correlations were statistically non-significant.

Conclusion
Secondary FM among OSA patients is not uncommon. Monitoring serum Vitamin D levels in OSA patients in recommended.
Impact of Human IFITM3 Polymorphism rs12252 on COVID-19 Severity and Mortality in an Egyptian Cohort
Authors: Mohamed Elessawy Sarah Mohamed Hesham , Ali Shehab Abeer Alsayed , Soliman Dina Ahmed , Eldeeb Mai Ahmed , Abdelfattah Taha Sara Ibrahim 
Published: July 2024

Abstract

Background
Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease with a high mortality rate, caused by infection with severe acute respiratory syndrome coronavirus 2. Variants of the gene encoding the interferon-induced membrane protein IFITM3 have been linked to severe viral illnesses. We investigated whether the COVID-19 clinical outcomes caused by SARS-CoV-2 infection in a cohort of COVID-19 Egyptian patients were inconsistent and could have been caused by the IFITM3-SNP rs12252 polymorphism.

Aim of the Work
The purpose of this study is to determine the frequency of the IFITM3 rs12252 SNP in a cohort of COVID-19 Egyptian patients, and its impact on illness severity and outcome, as well as its influence on IL-6 serum levels.

Patients and Methods
This cross-sectional study included 100 patients diagnosed as positive for COVID-19. They were enrolled in AL-Obour Quarantine Hospital. They were categorized into three groups, mild cases, who attended AL-Obour outpatient clinic, moderate and severe cases who were admitted to the hospital ward and ICU, respectively. All subjects of this study were subjected to full medical history, clinical evaluation, laboratory investigations, serum IL-6 levels by ELISA and IFITM3 gene polymorphism by real-time PCR.

Results
The results of the current study demonstrated a significant difference between mortality and the minor G allele of rs12252 within IFITM3 in COVID-19 patients (OR = 4.5 [95% CI; 1.4–14.30], P = 0.006). IL-6 showed no association either to disease severity or IFITM3 rs12252 genotype frequency.

Conclusion
The present study has shown a significant association between G allele variant of IFITM3 rs12252 and COVID-19 mortality. However, results failed to demonstrate any significant association between rs12252 polymorphism and disease severity, ICU admission or serum IL-6 levels. Therefore, understanding the interaction between SARS-CoV-2 and the IFITM3-rs12252 allele could help identify novel therapeutic targets, leading to precise biological and immune therapy for SARS-CoV-2 infection.