bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of efficacy of topical bepotastine besilate and alcaftadine in patients with vernal keratoconjunctivitis
Authors: Yadav Neha , Sachdeva Sumit , Rathi Manisha , Chhabra Sonia , Vashisth Shreay , Yadav Dinkar 
Published: July 2024

To compare efficacy of bepotastine besilate (1.5%) versus alcaftadine (0.25%) in patients with vernal keratoconjunctivitis.This comparative, randomized, single-blind and prospective study was conducted on 100 patients diagnosed with VKC, who were allocated to receive either of the two treatment groups. Group A received Alcaftdine eye drops once daily, while Group B received bepotastine besilate twice daily for 8 weeks. The efficacy assessment was done at baseline and then at 4 and 8 weeks post-treatment using following parameters - Primary endpoints included clinical symptoms score and clinical signs score and secondary endpoint included upper tarsal conjunctival brush cytology for eosinophil count.Intra-group analysis of clinical symptoms and clinical signs score showed statistically significant reduction in both scores and eosionophil count when compared to baseline values with both the drugs. On inter-group analysis, it was found that there was no statistically significant difference between the two groups in reduction in clinical symptoms and clinical signs score and eosinophil count. This study concluded that both drugs proved equally efficacious in relieving signs and symptoms of VKC. Difference in improvement of signs, symptoms, eosinophil count between both the groups drugs was not statistically significant.
Association between ocular pseudoexfoliation and cardiovascular disease status: An analysis in a multi-speciality Hospital
Authors: Annamalai Radha , Ramalingam Uma , James Jai Mercy 
Published: July 2024

Pseudoexfoliation syndrome (PEX) is the most common cause of secondary open angle glaucoma. It is a systemic disorder characterized by extracellular deposition of distinctive grey-white fibrillary amyloid like material. The material is found in the anterior segment of the eye, where it can be easily identified on ocular (slit- lamp) examination by ophthalmologists. This study was carried out to determine if an association does exist between ocular pseudoexfoliation and cardiovascular disease. This was a cross-sectional case-control study carried out from March 2023 to June 2023 at a tertiary hospital. A total of 46 cases (patients with ocular pseudoexfoliation) and 46 controls (patients without ocular pseudoexfoliation) were randomly selected from Ophthalmology Outpatient Department. Ophthalmological examination was done which included visual acuity testing using standard Snellen’s Chart, anterior segment assessment by slit lamp examination, Goldmann Applanation Tonometry to check intraocular pressure (IOP) and dilated fundus examination by direct/indirect ophthalmoscopy. Blood pressure (BP) was assessed and Electrocardiogram (ECG) was performed for all the patients undergoing the study. 2D Echocardiogram (ECHO) was done if ECG was abnormal. Analysis of the study results showed a positive association between ocular pseudoexfoliation and hypertension (HTN) and abnormal ECG. Also, the condition appeared to be more prevalent among the males. Since there is a positive association between pseudoexfoliation and cardiovascular diseases (CVD), ophthalmologists need to proactively investigate patients with PEX for cardiovascular abnormalities in form of HTN and abnormal ECG and refer them to physicians for appropriate management, if necessary.
A study of anterior chamber angle biometric measurements in closed angle glaucomas and healthy subjects using imaging tool
Authors: Bangra Sharwan Kumar , Sharma Manish , Parwal Sandeep 
Published: July 2024

This observational study aims to examine the ability of an imaging tool in differentiating between anterior chamber angle biometric measurements of closed angle glaucomas and healthy subjects.:This was a hospital based cross-sectional observational study. Seventy five subjects were grouped into three groups of 25 subjects each based on appropriate inclusion and exclusion criteria. Using AS-OCT, major outcome variables measured wereanterior chamber depth, lens thickness, lens vault and anterior opening distance 750 (AOD 750). Intraocular pressure and axial length were also noted.Statistical analysis showed that there was significant difference in IOP(p=0.02), axial length (p=0.0001), lens thickness (p=0.0001) and lens vault among the studied groups.The study results show that in phacomorphicglaucoma, anterior chamber depth was less and lens vault, axial length & angle opening distance 750 were more as compared to acute primary angle closure glaucoma.
A study on central corneal thickness in diabetics and non – diabetics
Authors: Mathukumalli Sumalath Sai Keerthi , Tumma Bharath , Mukkamala Narasimha 
Published: July 2024

Diabetes is one of the most leading causes of blindness with complications related to diabetic keratopathy (DK). This chronic metabolic stress makes changes in the endothelial cells of the cornea by loss in pleomorphism, corneal autofluorescence, degeneration of the cells due to stress leads to over hydration of the stroma leads to change in corneal thickness. The central corneal thickness is a sensitive indicator of corneal health and serves as an index for corneal hydration and metabolism. Accurate CCT measurement has diagnostic and therapeutic implications.Cross-sectional comparative study was done with 260 patients divided into two groups. Group 1 included patients with diabetes and group II patients without diabetes (Control group) of age group between 45 to 80 years who are attending Ophthalmology OPD in a time period of 2 months. Thorough history of patients was taken and underwent visual acuity testing, BCVA, IOP, fundus examination, HbA1c and CCT measurement using Optical Coherence Tomography (OCT).Mean CCT in diabetic population was 560.38±44.51 µm, while in control group was 500.32±39.63 µm with statistically significant p value of &#60;0.001. Correlation analysis shows duration of diabetes and HbA1c shows significant relation and age doesn’t show any correlation with CCT.Our study demonstrates that individuals with diabetes mellitus or increased levels of HbA1c had higher CCT, regardless of age or gender. This signifies that CCT was influenced by prolonged increased levels of blood glucose.
Study of serum vitamin D and homocysteine levels in patients with diabetic retinopathy and retinal vein occlusion
Authors: Sahay Shambhavi , Tadwalkar Archana , Menon Priyanka , Kumari Pooja 
Published: July 2024

Diabetic retinopathy and retinal vein occlusion are significant causes of vision loss in patients with diabetes. Emerging evidence suggests that vitamin D deficiency and elevated homocysteine levels may play a role in the pathogenesis of these conditions. This study investigates the serum levels of vitamin D and homocysteine in patients with diabetic retinopathy and retinal vein occlusion to elucidate potential associations.: Diabetic retinopathy (DR) is a sight threatening complications associated with diabetes mellitus. To find the correlation between vitamin D level and homocysteine plasma levels in patients of DR and Retinal Vein Occlusion patients.: Study the level of serum vitamin D and Homocysteine in patients with diabetic retinopathy as well as in retinal vein occlusions. A case control type of study was conducted on 100 cases (70 diabetic retinopathy and 30 retinal vein occlusion) and age matched 100 control. Detailed relevant history and complete ocular examination was done . Serum vitamin D and homocysteine levels were noted. In our study, majority of the patients belonged to & &#62; 60 years in the group of cases of diabetic retinopathy and most of the patients in the control group belonged to 50-60 years and & &#62; 60 years of age group (40%). Mean age in the cases and controls was equal (58.4±8.4)Majority of the patients in both cases (68.6%) and control (67.1%) group were males. Association was found to be statistically significant when chi square test (p = 0.03). The prevalence of hyper homocysteinenemia was also higher in DR group. The prevalence of hyperhomocystinemia was more in cases of diabetic retinopathy compared to controls. The prevalence of vitamin D deficiency was more in cases of diabetic retinopathy compared to controls and the difference was significant.
Visual evoked potential as an early assessment tool in ethambutol-induced toxic optic neuropathy during treatment of tuberculosis
Authors: Misra Anita , Sethi Santosh Kumar , Singh Partha 
Published: July 2024

The objective of this study was to determine whether visual evoked potential (VEP) may be utilized as a screening tool for Ethambutol-induced toxic optic neuropathy (EITON) and whether discontinuing the use of Ethambutol will reverse the signs and symptoms of EITON in patients who are suffering from tuberculosis.Following receipt of authorization from the Institutional Ethics Committee to proceed with the present study, the study officially got underway. The World Health Organization recommended that forty people who had been diagnosed with tuberculosis get ethambutol medication for a period of six months at a dosage of 15-19 milligrams per kilogram of body weight. These patients were inspected both before and after receiving the treatment. Visual function tests and visual evoked potential (VEP) tests were administered to each patient to assess the visual pathway's condition.An irregular VEP pattern was seen in seven patients out of forty individuals, which accounts for 17.5% of the total. Among these seven patients, delayed P100 latency was observed in all seven patients (17.5%), and an aberrant amplitude difference was documented in one patient (2.5%). There were four patients (10%) who were found to have suboptimal visual acuity, and there were three patients (7.5%) who were found to have problems with their colour vision. An association between low visual acuity and increased P100 delay values was discovered in three out of seven cases. This was the case that was investigated. One patient's visual acuity and colour vision had decreased after two months of Ethambutol therapy, while three patients' visual acuity and colour vision had decreased within four to six months of medication. Due to the absence of abnormalities in the fundus, a diagnosis of retrobulbar optic neuritis was made in these four cases, constituting 10% of the total. There was a full reversal of P100 delay in three patients (43%) out of seven and a partial reversal in four (57%) out of seven.Our study demonstrates that even at the recommended doses of ethambutol, a timely and routinely performed pattern VEP can detect a significant proportion of cases of subclinical optic neuritis. Furthermore, it demonstrates that the signs and symptoms of ocular toxicity can be reversed in a significant number of these patients after the cessation of Ethambutol treatment.
Retinal changes in anemia - A comparative cross sectional study using SD-OCT
Authors: Rajan Ann Reshma , Arun Sreelakshmi , Kakkanatt C. V. Anthrayose (Andrews) , Rafi Aboobacker Mohammed , Soman Brinda 
Published: July 2024

To study the retinal changes in various grades of anemia and compare them with controls by analysing the peripapillary RNFL (retinal nerve fibre layer) thickness and CDR (cup-disc ratio) in OCT.Anemia is a common health problem, iron deficiency (IDA) being the most common type. It has deleterious visual effects through enhancement of ischemic effects.Changes in RNFL and CDR are seen in many ischemic retinal diseases.Optical coherence tomography (OCT) is a non invasive imaging modality that gives a cross-sectional topographic imaging of retina.Our study aims at analysing RNFL thickness and CDR by OCT in our subjects.Our study was conducted including 44 each of anemic and non anemic people, after classifying the anemic group further based on WHO criteria. After detailed clinical examination, OCT was done and peri-papillary RNFL in 4 quadrants and vertical CDR were assessed and compared.Peripapillary RNFL thickness in anemia group was significantly thinner than controls, the change more pronounced in severe anemia than other groups. CDR was significantly high in severe anemia than others.Retinal changes in anemia has a correlation with the severity of anemia. RNFL and CDR changes can predispose to serious visual defects in future. Hence, anemia screening and correction along with frequent clinical and OCT evaluation in such patients can be useful in early detection and prevention of anemic retinopathy.
Epiretinal membrane associated with combined hamartoma of retina pigment epithelium: Surgical outcome and histopathological features
Authors: Al Jarallah Othman Jarallah 
Published: July 2024

Combined hamartoma of the retina and retinal pigment epithelium (CHR-RPE) represents a rare, benign congenital anomaly typically presenting as slightly elevated, variably pigmented lesions. This report details the surgical outcome and histopathological features of an epiretinal membrane associated with CHR-RPE. A 29-year-old woman with a three-year history of gradual visual decline in her right eye underwent a comprehensive ophthalmologic examination, including spectral domain optical coherence tomography (SD-OCT), which revealed characteristic features of CHR-RPE and an overlying epiretinal membrane. She subsequently elected to undergo pars plana vitrectomy with membrane peeling. Intraoperative findings confirmed the presence of histological elements consistent with the internal limiting membrane, fibrillar collagen, vitreous, and cells positive for glial fibrillary acidic protein (GFAP), indicative of glial cells. Postoperatively, there was a noticeable improvement in the retinal architecture; however, visual acuity improvement was minimal. Histopathological analysis of the excised membrane provided insight into the lesion’s cellular composition. This case underscores the complex nature of CHR-RPE associated with epiretinal membranes and the challenges in achieving significant visual acuity improvement despite successful surgical intervention. It highlights the importance of early detection and a personalized approach to management. Future research should focus on optimizing treatment strategies and improving understanding of the prognosis for similar cases.
Droga do wojny. II Republika Hiszpańska 1931-1936
Authors: De la Fuente de Pablo Pablo , Taracha Cezary 
Published: July 2024

Artykuł ten ma pod względem koncepcyjnym charakter zarówno syntetyczny, jak i analityczny. Wyjaśnia przyczyny rażącej porażki Drugiej Republiki w Hiszpanii. Był to system polityczny, w którym państwo stało się zaciekłym wrogiem znacznej części narodu. Skandaliczne oszustwo wyborcze w lutym 1936 r. było preludium krwawej wojny domowej.
Recursos e energia organizacional produtiva: a mediação da motivação no trabalho
Authors: Gabardo-Martins Larissa , Silva Louro Evânia , Tinoco Caldas Amanda 
Published: July 2024

Com base no Modelo JD-R, objetivou-se testar a mediação da motivação no trabalho nas relações da autonomia no trabalho e da autoeficácia no trabalho com a energia organizacional produtiva. A amostra compôs-se de 464 trabalhadores brasileiros, de ambos os sexos. Os resultados da Modelagem de Equações Estruturais evidenciaram uma relação entre a autonomia no trabalho e a autoeficácia no trabalho com a energia organizacional produtiva, e demonstraram a mediação da motivação no trabalho. Tais achados oferecem diferentes contribuições teóricas e práticas para a área da Psicologia Organizacional ao contribuir para o planejamento e implementação de estratégias que podem elevar o desempenho dos empregados e proporcionar uma conquista de vantagem competitiva para as organizações que investirem em seu capital humano.
D-DIMER AS A PROGNOSIS OF THE SEVERITY OF COVID-19 PATIENTS AT BEKASI REGENCY HOSPITAL
Authors: Kurniawati Dyah Eka 
Published: July 2024

The increase in D-dimer is the most significant change in coagulation parameters in Covid-19 patients and can be a marker of poor prognosis. The purpose of this study was to see the average significant D-dimer levels in patients with confirmed Covid-19 with severity. The method used is Retrospective Research with a purposive sampling technique based on the criteria of the severity of Covid-19 disease. Patient data was taken from medical records and D-dimer levels from the Laboratory Information System and then analyzed using a one-way Anova test. The results showed an average D-dimer level of 2.66 mg/L at critical degrees, 2.02 mg/L at severe degrees, 0.30 at moderate degrees and 0.26 at mild degrees. Male patients occupy a larger percentage than female patients with a total of 62.5%. The age of 46-65 years occupies the highest percentage of 55% for the abnormal category because the immune system as a protector of the body does not work as strongly as when it was young. This study showed a significant average difference in the groups of mild severity with severe, mild with critical, moderate with severe, and moderate with critical. For the next researcher, it is expected to be able to analyze other hemostasis examination parameters with variables of disease severity.
Kata kunci: Coronavirus, COVID-19, D-dimer, parameter koagulasi, pembekuan darah
OSTEOINDUCTIVE CAPACITY OF PLATELET-RICH FIBRIN VS BIODENTINE FOR MANDIBLE FRACTURE
Authors: Marda Agung Nugraha  , Indra Mulyawan  , Ardian Jaya Kusuma Amran  
Published: July 2024

Highlights

Biodentine has undergone thorough research as a bone grafting substance due to its ability to promote bone regeneration and effectively treat root or tooth fractures.
PRF and Biodentine can stimulate osteogenesis, affecting bone repair, particularly in mandibular fractures.

Abstract
Background: Mandibular fracture is one of the most common fractures. The most common treatment for mandibular fractures is fixation. Therefore, xenogeneic agents such as platelet-rich fibrin (PRF) and Biodentine accelerate the reparative process. Biodentine is an interesting active ingredient that can induce bone regeneration. PRF and Biodentine can promote bone healing, but no literature discusses the differences between PRF and Biodentine osteoinduction mechanisms in treating mandibular fractures. Objective: This article aimed to compare the effect of osteoinductive PRF with Biodentine for mandibular fractures. Material and Method: The research was conducted as a scoping review by performing a thorough search of the PubMed, Scopus, Science Direct, Elsevier, and Google Scholar databases. The study was obtained based on literature studies in the form of journals and textbooks in the last ten years (2013-2023). Result: The osteoinductive effect and mechanism of Biodentine in enhancing bone repair are likely correlated with releasing biologically active ions from calcium silicate cement and stimulating gene expression Runx-2. PRF has an osteoinductive role, causing the mechanism of releasing growth factors such as PDGF, VEGF, TGF-Î², and IGF that promote the osteogenic process. Conclusion: There was no significant difference in the osteoinduction effect of PRF and Biodentine because these materials have different mechanisms of action for bone repair.
Characteristics of <i>Vibrio cholerae</i> O1 CTX<sup>+</sup> Strain Isolated from the Temernik River in Rostov-on-Don in 2023
Authors: Monakhova E. V. , Kruglikov V. D. , Vodop’yanov A. S. , Krasnov Ya. M. , Katyshev S. D. , Sharapova N. A. , Alekseeva L. P. , Men’shikova E. A. , Evdokimova V. V. , Ezhova M. I. , Noskov A. K. 
Published: July 2024

The aim of the work was to determine the pheno- and genotypic features of the aquatic CTX+ strain of Vibrio cholerae isolated in 2023 and a comparative bioinformatic analysis of whole-genome sequencing data.Materials and methods. Whole-genome sequencing was performed on MiSeq (Illumina) and MinIon Oxford Nanopore Technologies (ONT) platforms; hybrid assembly of the whole genome was carried out using the Trycycler algorithm; assembly errors were eliminated by means of the Medaka algorithm and the Pilon program. Dendrogram construction and bioinformatics analysis were carried out with the help of the scipy and Graphviz packages, BioEdit, BLASTN, BLASTP, CARD, ICE Genotyper, and Vector NTI programs. The ability to produce cholera toxin was tested using the GM1ELISA.Results and discussion. The isolated strain was identified as V. cholerae O1 Ogawa, sensitive to most antibiotics. Based on the totality of genetic properties, it was classified as the first genovariant, distinct from the typical El Tor strains only by the presence of ctxB1 gene of classical type instead of ctxB3 of the El Tor type. It has been established that it contains a tandemly duplicated CTX prophage on the small chromosome and a tandem of two copies of RS1 prophage on the large chromosome. Thereat, the rstR gene of the CTX prophage belonged to the classical type, and the RS1 prophage – to the El Tor type. The remaining criteria of epidemic hazard – tcpAelt, rtxA1 and intact VSP-II did not differ from the prototypes. The genome of the strain carries the ICE element VchBan11, which contains the trimethoprim resistance gene dfrA1, and phenotypically the strain is resistant to this antibiotic. Under in vitro conditions, the strain did not produce cholera toxin, as shown by ELISA results. This may be due to the presence of a deletion within the toxR regulatory gene. Strains similar to the 2023 isolate are mainly attributed to the second wave of the seventh pandemic. Currently, they are almost replaced by new genovariants, but occasionally can emerge and even cause diseases. Therefore, their importation into Russian territory potentially pose a threat to public health.
Organization of Joint Laboratory Studies during Sanitary and Epidemiological Interventions in the Republic of the Congo by Rospotrebnadzor Specialists
Authors: Portenko S. A. , Naidenova E. V. , Agafonov D. A. , Kuznetsova D. A. , Evteev A. V. , Tushinsky A. A. , Dmitrieva L. N. , Katyshev A. D. , Kuklev V. E. , Obissa N. , Mabiala V. , Loubano J. , Mpompolo M. , Mobousse Misse J.-C. , Shcherbakova S. A. , Kutyrev V. V. 
Published: July 2024

The study presents the data on organization of laboratory testing of clinical and environmental samples within the framework of establishing the etiology of the acute intestinal infections outbreak, performed by the specialists of the joint SAET of the Rospotrebnadzor in Dolisie (Republic of the Congo) in the period of 07–24 July, 2023.Materials and methods. In order to identify the causative agents of cholera and other acute intestinal infections of bacterial and viral nature, 177 clinical and environmental samples were tested, as well as cultures on solid nutrient media and bacterial suspensions. A total of 1023 tests were carried out by polymerase chain reaction (PCR) and 305 – using bacteriological method.Results and discussion. The causative agent of cholera has not been detected in any of the samples tested. Using the PCR method, markers of acute intestinal diseases agents (Salmonella spp., Shigella spp., Campylobacter spp., Rotavirus A) have been identified in 23 clinical samples and 1 sample of bacterial suspension. No DNA/RNA of pathogens has been detected in environmental samples. During culture studies, Salmonella enterica serovar Typhi have been isolated from 8 clinical samples, and their antibiotic sensitivity has been determined. Applying whole-genome nanopore sequencing, using the MinIon platform (Oxford Nanopore Technologies, UK), nucleotide sequences of 4 S. Typhi isolates have been investigated and deposited in the international database NCBI GenBank (No. CP141260, CP141193, CP141194, CP141195). Additionally, the analysis of initially sterile samples (blood, peritoneal fluid, intraoperational samples) from the patients of General and Reference hospitals of Dolisie has resulted in the identification of 5 cultures of non-fermenting bacteria, and their antibiotic sensitivity has been determined.