bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structures of Uncharacterised Polymorphs of Gallium Oxide from Total Neutron Diffraction
Authors: Playford Helen Y. , Hannon Alex C. , Barney Emma R. , Walton Richard I. 
Published: January 2013

AbstractA structural investigation is reported of polymorphs of Ga2O3 that, despite much interest in their properties, have hitherto remained uncharacterised due to structural disorder. The most crystalline sample yet reported of γ‐Ga2O3 was prepared by solvothermal oxidation of gallium metal in ethanolamine. Structure refinement using the Rietveld method reveals γ‐Ga2O3 has a defect Fd$\bar 3$m spinel structure, while pair distribution function analysis shows that the short‐range structure is better modelled with local F$\bar 4$3m symmetry. In further solvothermal oxidation reactions a novel gallium oxyhydroxide, Ga5O7(OH), is formed, the thermal decomposition of which reveals a new, transient gallium oxide polymorph, κ‐Ga2O3, before transformation into β‐Ga2O3. In contrast, the thermal decomposition of Ga(NO3)3⋅9 H2O first forms ε‐Ga2O3 and then β‐Ga2O3. Examination of in situ thermodiffraction data shows that ε‐Ga2O3 is always contaminated with β‐Ga2O3 and with this knowledge a model for its structure was deduced and refined—space group P63mc with a ratio of tetrahedral/octahedral gallium of 2.2:1 in close‐packed oxide layers. Importantly, thermodiffraction provides no evidence for the existence of the speculated bixbyite structured δ‐Ga2O3; at the early stages of thermal decomposition of Ga(NO3)3⋅9 H2O the first distinct phase formed is merely small particles of ε‐Ga2O3.
Highly Efficient Synthesis of Globular (Bola)amphiphilic [5:1]Hexakisadducts of C60
Authors: Hörmann Frank , Brettreich Michael , Donaubauer Wolfgang , Hampel Frank , Hirsch Andreas 
Published: January 2013

AbstractWe report on the very facile access of a new family of amphiphilic and bola‐amphiphilic fullerene [5:1]hexakisadducts 9 a–f and 11 a–e. The key point for this successful approach is the use of C2v‐symmetrical fullerene pentakisadduct precursors 2 b–f allowing for the completely regioselective addition of a sixth malonate addend to complete the octahedral [5:1] addition pattern. For the synthesis of the new amphiphiles we first developed a new second‐generation dendrimer containing 9 tert‐butoxycarbonyl (Boc)‐protected amino functions at the periphery and two new malonates containing 6 or 18 Boc‐protected amino termini, respectively. The hexakisadducts contain up to 18 positive or negative charges at the dendritic moiety and either no or ten positive or negative charges at the unbranched malonate positions after deprotection with trifluoroacetic acid (TFA). The charge state at the termini is pH‐dependent. Complete structural characterization of the new compounds was carried out by ESI mass spectrometry and by UV/Vis, FTIR, 1H NMR and 13C NMR spectroscopy. We were also able to obtain the first X‐ray crystal structure of pentakisadduct (2 a) with a C2v‐symmetrical addition pattern. The new amphiphilic hexakisadducts show interesting solubility properties in water. Initial investigations on the aggregation properties of the amphiphilic hexakisadduct 12 c by using dynamic light scattering (DLS) and conductivity measurements, show aggregates with a radius up to 200 nm and a critical micelle concentration (CMC) of approximately 8 mg L−1.
A phase 2 study of epothilone B analog BMS‐247550 (NSC 710428) in patients with relapsed aggressive non‐Hodgkin lymphomas
Authors: Churpek Jane E. , Pro Barbara , van Besien Koen , Kline Justin , Conner Kathy , Wade James L. , Hagemeister Fredrick , Karrison Theodore , Smith Sonali M. 
Published: January 2013

AbstractBACKGROUND:The management of relapsed aggressive lymphomas remains problematic. Ixabepilone (BMS‐247550, epothilone B analog), a potent inhibitor of tubulin disassembly, has promising preclinical and early‐phase clinical activity in drug‐resistant malignancies.METHODS:This multicenter phase 2 clinical trial tested the activity and safety of ixabepilone in relapsed/refractory aggressive lymphoma patients with either chemosensitive (at least a partial response [PR] to most recent chemotherapy) or chemoresistant (less than PR to most recent chemotherapy) disease at 20 mg/m2given intravenously weekly on days 1, 8, and 15 of a 28‐day cycle.RESULTS:Fifty‐one enrolled patients with a median age of 66 years received at least 1 dose of ixabepilone. Diffuse large B‐cell lymphoma (n = 25; 49%), mantle cell lymphoma (n = 16; 31%), and transformed follicular lymphoma (n = 5; 10%) were the most frequent histologies. Patients were heavily pretreated, with more than one‐quarter having received 4 or more prior therapies. The overall response rate was 27% (14 of 51 patients) with 12% (6 patients) experiencing complete responses and 16% (8 patients) with PRs. All responses were in patients with chemosensitive disease. The median time to response was 2 cycles with a median duration of response of 9.7 months.CONCLUSIONS:Ixabepilone was well‐tolerated, with neutropenia, peripheral sensory neuropathy, fatigue, and nausea as the major toxicities. Ixabepilone has modest single‐agent activity in patients with recurrent chemosensitive aggressive lymphomas. Cancer 2013. © 2013 American Cancer Society.
Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence‐related prognostic indicator in stage I esophageal squamous cell carcinoma
Authors: Lee Eunju , Lee Bo Bin , Ko Eunkyung , Kim Yujin , Han Jungho , Shim Young Mog , Park Joobae , Kim Duk‐Hwan 
Published: January 2013

AbstractBACKGROUND:The objective of this study was to discover molecular biomarkers associated with the recurrence of esophageal squamous cell carcinoma (ESCC).METHODS:The authors retrospectively analyzed the hypermethylation status of 11 genes using methylation‐specific polymerase chain reaction (PCR) and the expression of epidermal growth factor receptor (EGFR), O‐6 methylguanine‐DNA methyltransferase (MGMT), tumor protein 53 (p53), and transforming growth factor β (TGFβ) using immunohistochemistry in 329 formalin‐fixed, paraffin‐embedded ESCCs.RESULTS:Recurrence was identified in 151 of 329 ESCCs (46%) at a median follow‐up of 4.5 years. The recurrence was associated with hypermethylation of the genes cell adhesion molecule 1 (CADM1) (P = .003), deleted in colon carcinoma (DCC) (P = .04), or cyclin‐dependent kinase inhibitor 2A (p14) (P = .02) in patients with stage I ESCC. Thirty‐six of 37 Stage I ESCCs (97%) that had cohypermethylation of at least 2 of the 3 genes had hypermethylation of p14 plus either CADM1 or DCC or both CADM1 and DCC. The 5‐year recurrence‐free survival (RFS) rates were 93% in patients who had stage I disease without hypermethylation of the 3 genes and 56% in those who had cohypermethylation of p14 in combination with CADM1 and/or DCC. Patients who had stage I ESCC with cohypermethylation of p14 in combination with DCC and/or CADM1 had 7.13 times (95% confidence interval, 1.61‐31.64 times; P = .009) poorer RFS compared with those who had no hypermethylation of the 3 genes after adjusting confounding factors. Hypermethylation of the other 8 genes and altered expression of 4 proteins were not associated with recurrence across pathologic stages.CONCLUSIONS:The current results suggested that cohypermethylation of p14 in combination with DCC and/or CADM1 may be an independent prognostic factor for recurrence in patients with stage I ESCC. Cancer 2013. © 2013 American Cancer Society.
The monoterpene (–)‐carvone: A novel agonist of TRPV1 channels
Authors: Gonçalves Juan Carlos R. , Silveira Alethéia L. , de Souza Héllio D. N. , Nery Arthur A. , Prado Vania F. , Prado Marco A. M. , Ulrich Henning , Araújo Demetrius A. M. 
Published: January 2013

Abstract(–)‐Carvone is an antinociceptive monoterpene found as the main active constituent of essential oils obtained from plants of the genus Mentha. Here, we have investigated the pharmacology of this monoterpene in dorsal root ganglia (DRG) neurons and TRPV1‐expressing HEK293 cells. (–)‐carvone at pharmacological active concentrations did not reveal significant cytotoxicity to the cells used in this study, as investigated by neutral red and propidium iodide flow cytometry assays. In calcium imaging experiments 1 mM (–)‐carvone increased the cytosolic calcium levels in DRG neurons from 120.6 ± 5.0 nM (basal) to 310.7 ± 23.1 nM (P < 0.05). These effects were completely abolished when neurons were preincubated with calcium‐free bath solution or ruthenium‐red (5 µM) and capsazepine (10 µM), suggesting the possibility of TRPV1 channel‐activation by (–)‐carvone. Activity of (–)‐carvone on TRPV1 channels was further investigated in HEK293 cells expressing recombinant human TRPV1 channels revealing dose‐dependent calcium transients with an EC50 of 1.3 ± 0.2 mM (Hill coefficient = 2.5). In conclusion, we show for the first time the ability of (–)‐carvone to induce increases in cytosolic calcium concentration through TRPV1 activation. © 2013 International Society for Advancement of Cytometry
Size Effect and Role of Short‐ and Long‐Range Interactions on 1D Spin‐Crossover Systems within the Framework of an Ising‐Like Model
Authors: Chiruta Daniel , Linares Jorge , Dimian Mihai , Garcia Yann 
Published: January 2013

AbstractThis contribution, motivated by an experimental study of the influence of long‐range interactions on the hysteresis loop, presents a theoretical study of spin‐state transitions within the framework of an Ising‐like model. The Hamiltonian includes both short‐ and long‐range interactions and takes into account different degeneracies between molecular states. The problem is solved exactly for one‐dimensional systems by using a transfer matrix method and the effects of temperature, long‐ and short‐range interactions, and system size (number of molecules) are analysed in depth. The width of the thermal hysteresis loop of spin‐crossover compounds decreases when reducing the long‐range interactions, down to a critical value, calculated for the first time in this contribution, at which the hysteresis vanishes. This dependence is similar to the one generated by the decrease in short‐range interactions assuming that the corresponding variation is proportional. An increase in the system size contributes to a larger influence of long‐range interactions and the hysteretic loop approaches a rectangular shape and reaches a saturation width, which is predicted for the first time. These results are important for the design of novel spin‐crossover materials featuring sharp spin transitions along with wide hysteresis loops, which are particularly suited for potential applications in display and data storage devices.
Ruthenium‐Catalyzed Selective Aerobic Oxidative ortho‐Alkenylation of Substituted Phenols with Alkenes through C–H Bond Activation
Authors: Reddy Mallu Chenna , Jeganmohan Masilamani 
Published: January 2013

AbstractThe oxidative coupling of phenyl carbamates and acetates with alkenes in the presence of a catalytic amount of [RuCl2(p‐cymene)]2, AgSbF6, and Cu(OAc)2·H2O under air provided substituted alkene derivatives in a highly regio‐ and stereoselective manner. The catalytic reaction was compatible with various alkenes such as acrylates, vinyl sulfones, acrylonitrile, and substituted styrenes. The present catalytic reaction was also compatible with phenyl carbamates and acetates with various electron‐rich, electron‐deficient, and halogen substituents on the aromatic ring. Further examination of the catalytic reaction was done with the substituted phenyl acetates. By using LiOH·H2O or K2CO3 as a base, the substituted alkene derivatives were converted into the corresponding phenol derivatives. To account for the catalytic reaction, a possible mechanism is proposed that involves a six‐membered ruthenacycle as the key intermediate.
Facile and Simultaneous Stripping Determination of Zinc, Cadmium and Lead on Disposable Multiwalled Carbon Nanotubes Modified Screen‐Printed Electrode
Authors: Fu Liang , Li Xueling , Yu Jianshuan , Ye Jianshan 
Published: January 2013

AbstractScreen‐printed electrodes (SPEs) are cheap and disposable. But their application for heavy metal detection is limited due to the low sensitivity and poor selectivity. Here we report the ultrasensitive and simultaneous determination of Zn2+, Cd2+ and Pb2+ on a multiwalled carbon nanotubes and Nafion composite modified SPE with in situ plated bismuth film (MWCNTs/NA/Bi/SPE). The linear curves range from 0.5–100 µg L−1 for Zn2+ and 0.5–80 µg L−1 for Cd2+. Uniquely, the linear curve for Pb2+ ranges from 0.05–100 µg L−1 with a detection limit of 0.01 µg L−1. The practical application was verified in real samples with satisfactory results.
LTE networking: extending the reach for sensors in mHealth applications
Authors: Adibi Sasan , Mobasher Amin , Tofigh Tom 
Published: January 2013

ABSTRACTSensor and electronic‐health networks are widely utilized at home and in industry/research applications. In a local sense, a sensor‐to‐sensor network can have a range of a few meters to a couple of hundred meters (ZigBee Pro can extend this range up to 2000 m). With the deployment of mobile technology in the healthcare space (mobile‐Health ‘m‐Health’) and using cellular coverage, the range can virtually be unbounded. However, supporting bounded delay (end‐to‐end delay), class of service, and quality of service for critical sensor‐mHealth applications may become challenging. This challenge can be alarmingly extended when thousands of users run their sensor‐mHealth applications simultaneously and depend on limited coverage of the cell tower to transmit their health‐related data across. In this paper we will discuss how the 3rd Generation Partnership Project–Long Term Evolution networks can address such aggregation issues, and discuss the challenges and provide recommendations.Copyright © 2013 John Wiley & Sons, Ltd.
A robust non‐data‐aided SNR estimation method for OFDM systems
Authors: Sheng Bin 
Published: January 2013

AbstractThe information of signal‐to‐noise ratio (SNR) plays an important role in orthogonal frequency division multiplexing (OFDM) systems. Some applications, such as cognitive radio, need non‐data‐aided (NDA) estimation of SNR. In this paper, we propose a robust NDA SNR estimation method, which is developed on the basis of the cyclic prefix of OFDM symbol. The proposed method is immune to the inter‐symbol interference caused by multipath channel and can thus obtain an unbiased estimate of the signal power even in the low‐SNR regime. Copyright © 2013 John Wiley & Sons, Ltd.
Importance of Different Types of Prior Knowledge in Selecting Genome‐Wide Findings for Follow‐Up
Authors: Minelli Cosetta , De Grandi Alessandro , Weichenberger Christian X. , Gögele Martin , Modenese Mirko , Attia John , Barrett Jennifer H. , Boehnke Michael , Borsani Giuseppe , Casari Giorgio , Fox Caroline S. , Freina Thomas , Hicks Andrew A. , Marroni Fabio , Parmigiani Giovanni , Pastore Andrea , Pattaro Cristian , Pfeufer Arne , Ruggeri Fabrizio , Schwienbacher Christine , Taliun Daniel , Pramstaller Peter P. , Domingues Francisco S. , Thompson John R. 
Published: January 2013

ABSTRACTBiological plausibility and other prior information could help select genome‐wide association (GWA) findings for further follow‐up, but there is no consensus on which types of knowledge should be considered or how to weight them. We used experts’ opinions and empirical evidence to estimate the relative importance of 15 types of information at the single‐nucleotide polymorphism (SNP) and gene levels. Opinions were elicited from 10 experts using a two‐round Delphi survey. Empirical evidence was obtained by comparing the frequency of each type of characteristic in SNPs established as being associated with seven disease traits through GWA meta‐analysis and independent replication, with the corresponding frequency in a randomly selected set of SNPs. SNP and gene characteristics were retrieved using a specially developed bioinformatics tool. Both the expert and the empirical evidence rated previous association in a meta‐analysis or more than one study as conferring the highest relative probability of true association, whereas previous association in a single study ranked much lower. High relative probabilities were also observed for location in a functional protein domain, although location in a region evolutionarily conserved in vertebrates was ranked high by the data but not by the experts. Our empirical evidence did not support the importance attributed by the experts to whether the gene encodes a protein in a pathway or shows interactions relevant to the trait. Our findings provide insight into the selection and weighting of different types of knowledge in SNP or gene prioritization, and point to areas requiring further research.
Preserving ecosystem services in urban regions: Challenges for planning and best practice examples from Switzerland
Authors: Tobias Silvia 
Published: January 2013

Abstract
This article presents a literature review that explores the challenges for planning in urban regions in connection with the preservation of ecosystem services. It further presents some best practice examples for meeting these challenges. The demand for the provision of ecosystem services within urban regions changed during the transition from a largely agrarian society to an industrial society and, most recently, to a service society. Although in the past, provisioning services such as food production or the provision of raw material were decisive for urban development, today cultural services, e.g., clear views or nearby recreation areas, have become increasingly important. According to the literature, soil sealing is the greatest threat urbanization poses toward ecosystem services, as it compromises all of them. Spatially extensive cities with a high building density particularly inhibit regulating services like the regulation of temperature or water surface runoff. Conversely, scattered settlement patterns may lead to very small remnants of open space that cannot reasonably serve as natural habitat, agricultural land, or recreation area. The challenges for planning in urban regions are: 1) specifying regulations that define outer limits to the development of each settlement unit, 2) comprehensive planning with focal points for development, and limiting access and development at other places, and 3) compensating for new soil sealing by restoring nearby sealed areas. The article presents 3 best-practice examples that support these principles: designating areas with a particular soil quality that should not be built over, offering incentives for corporate planning in urban regions, and restoring a country road in connection with a motorway construction. Integr Environ Assess Manag 2013; 9: 243–251. © 2013 SETAC
QUALITY OF DRAINAGE WATER UNDER IRRIGATED COTTON IN VERTISOLS OF THE LOWER NAMOI VALLEY, NEW SOUTH WALES, AUSTRALIA
Authors: Weaver T. B. , Hulugalle N. R. , Ghadiri H. , Harden S. 
Published: January 2013

ABSTRACTComparative research on the effects of soil and crop management practices in cotton farming systems on the quality of drainage water in irrigated Vertisols has not been reported in the literature. The objective of this study was to quantify drainage water quality in the subsoil (0.6, 0.9, 1.2 m) of sodic and non‐sodic Vertisols under selected crop rotations, viz. continuous cotton (Gossypium hirsutum L.), cotton–dolichos (Lablab purpureus L.) and cotton–wheat (Triticum aestivum L.). The experimental sites were located at the Australian Cotton Research Institute (ACRI) near Narrabri and on two commercial cotton farms near Wee Waa and Merah North in northern New South Wales, Australia. A cotton–wheat rotation was sown at Wee Waa and ACRI; wheat stubble was incorporated in the former and retained as in situ mulch in the latter. At Merah North, there were three cropping sequences; viz. continuous cotton, cotton–wheat, and cotton–dolichos sown between 1993 and 2000 in adjacent plots with identical land management histories. The three treatments were sown with cotton during the 2000–2001 and 2002–2003 growing seasons, wheat during the 2001 winter and sorghum during the 2001–2002 growing season with stubble being incorporated. Drainage water was sampled with 50‐mm diameter ceramic‐cup samplers from depths of 0.6, 0.9 and 1.2 m in six sites in each plot and irrigation water from the head ditch after irrigation between mid October and late February during the cotton‐growing seasons of 2000‐2001 and 2002–2003. Soil water extracted from the ceramic‐cup samplers was analysed for pHw, ECw, Cl‐, NO3‐‐N, K+, Ca2+, Mg2+ and Na+. Salt and nutrient concentrations in drainage water varied among sites, and reflected variations in soil properties, fallow length since the preceding crop, fallow rainfall and irrigation water quality. Salinity and SAR of drainage water were many times higher than those of irrigation water. Salinisation and sodification of shallow groundwater reserves under irrigated cotton in Vertisols are, therefore, a distinct possibility. Salinisation and sodification of the root zone may occur in cotton‐based rotations that result in poor subsoil structure and, thus, limited drainage even when irrigated with water of a quality that is generally accepted as being ‘reasonable’. Copyright © 2013 John Wiley & Sons, Ltd.
Traditional Machismo and Caballerismo as Correlates of Posttraumatic Stress Disorder, Psychological Distress, and Relationship Satisfaction in Hispanic Veterans
Authors: Herrera Catherine J. , Owens Gina P. , Mallinckrodt Brent 
Published: January 2013

An online survey was used to examine 45 Hispanic male veterans’ traditional machismo and caballerismo as correlates of posttraumatic stress disorder (PTSD), psychological distress, and relationship satisfaction. Higher traditional machismo was associated with higher PTSD severity and distress and lower relationship satisfaction. Psychometric properties of the Traditional Machismo and Caballerismo Scale were explored.Se utilizó una encuesta en línea para examinar el machismo y el caballerismo tradicionales de 45 veteranos hispanos varones, y su correlación con el trastorno de estrés post‐traumático (PTSD, por sus siglas en inglés), la angustia psicológica y la satisfacción en sus relaciones. Un mayor nivel de machismo tradicional se asoció con una mayor severidad del PTSD, así como con angustia y una menor satisfacción en las relaciones. Se exploraron las propiedades psicométricas de la Escala de Machismo y Caballerismo Tradicionales.
Racism‐Related Stress, General Life Stress, and Psychological Functioning Among Black American Women
Authors: Pieterse Alex L. , Carter Robert T. , Ray Kilynda V. 
Published: January 2013

The relationship between general life stress, perceived racism, and psychological functioning was explored in a sample of 118 Black American women. Findings indicate that racism‐related stress was not a significant predictor of psychological functioning when controlling for general life stress. Perceived racism was positively associated with general life stress. Implications for practice and future research are discussed.La relación entre el estrés general de la vida, el racismo percibido y el funcionamiento psicológico se exploraron en una muestra de 118 mujeres afroamericanas. Los resultados indican que el estrés relacionado con el racismo no fue un pronosticador significativo del funcionamiento psicológico cuando se controló estadísticamente para tomar en cuenta el estrés general de la vida. El racismo percibido estuvo asociado positivamente con el estrés general de la vida. Se discuten las implicaciones para la práctica e investigaciones futuras.