bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-370 sensitizes chronic myeloid leukemia K562 cells to homoharringtonine by targeting Forkhead box M1
Authors: Zhou MinRan , Zeng JiPing , Wang XiaoMing , Guo Qing , Huang Tao , Shen HaiYu , Fu Yue , Wang LiXiang , Jia JiHui , Chen ChunYan 
Published: October 2013

Abstract

Background
Homoharringtonine (HHT) is a kind of cephalotaxus alkaloid used in traditional Chinese medicine. Although HHT has been successfully used as a therapeutic agent for leukemia, the drug resistance and toxicity are major concerns. MicroRNAs (miRNAs) have been identified to modulate cellular sensitivity to anticancer drugs. We examined the synergistic action between miR-370 and HHT in vitro and in vivo.

Methods
The synergistic action between miR-370 and HHT was examined by flow cytometry. The effect of HHT on miR-370 expression was determined by quantitative RT-PCR (qRT-PCR). The expression of miR-370 and Forkhead box M1 (FoxM1) in 23 patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP) and 10 patients with blast-crisis CML (CML-BP) as well as miR-370–targeted FoxM1 was determined by qRT-PCR and western blot analysis.

Results
Ectopic expression of miR-370 sensitized the CML K562 cell line to HHT by targeting FoxM1, the major regulator in cell proliferation and apoptosis. miR-370 significantly promoted HHT-mediated cell apoptosis and miR-370 and HHT cooperated in affecting FoxM1 expression. As well, miR-370 was moderately upregulated after HHT treatment in K562 cells. In addition, the expression of miR-370 was significantly reduced in CML patients as compared with healthy controls. Furthermore, the expression of miR-370 was lower in CML-BP than CML-CP patients.

Conclusions
MiR-370 sensitized K562 cells to HHT by inducing apoptosis in part by downregulation of FoxM1 expression. These findings may provide further information for CML treatment with HHT.
Improvement of optical transmittance and electrical properties for the Si quantum dot-embedded ZnO thin film
Authors: Kuo Kuang-Yang , Liu Chuan-Cheng , Huang Pin-Ruei , Hsu Shu-Wei , Chuang Wen-Ling , Chen You-Jheng , Lee Po-Tsung 
Published: October 2013

Abstract
A Si quantum dot (QD)-embedded ZnO thin film is successfully fabricated on a p-type Si substrate using a ZnO/Si multilayer structure. Its optical transmittance is largely improved when increasing the annealing temperature, owing to the phase transformation from amorphous to nanocrystalline Si QDs embedded in the ZnO matrix. The sample annealed at 700°C exhibits not only high optical transmittance in the long-wavelength range but also better electrical properties including low resistivity, small turn-on voltage, and high rectification ratio. By using ZnO as the QDs’ matrix, the carrier transport is dominated by the multistep tunneling mechanism, the same as in a n-ZnO/p-Si heterojunction diode, which clearly differs from that using the traditional matrix materials. Hence, the carriers transport mainly in the ZnO matrix, not through the Si QDs. The unusual transport mechanism using ZnO as matrix promises the great potential for optoelectronic devices integrating Si QDs.
Ectopic pancreatic pseudocyst and cyst presenting as a cervical and mediastinal mass - case report and review of the literature
Authors: Rokach Ariel , Izbicki Gabriel , Deeb Maher , Bogot Naama , Arish Nissim , Hadas-Halperen Irith , Azulai Hava , Bohadana Abraham , Golomb Eli 
Published: October 2013

Abstract
Ectopic pancreas in the mediastinum is extremely rare. We are reporting on a case of a twenty two year old woman who presented to our clinic with a large cervical mass. The CT scan revealed a cystic lesion in the anterior mediastinum. The patient underwent surgical resection by cervical approach. A Cystic mass with pseudocysts, cysts and complete pancreatic tissue were found in pathology. There were no signs of pancreatitis or malignancy. No recurrence was observed after a follow up of four years. We reviewed the case reports describing this rare condition in the medical literature.
We conclude that the possibility of ectopic pancreatic tissue should be included in the differential diagnosis of anterior mediastinal cystic mass, though as a remote possibility. Surgery is probably needed for the diagnosis and treatment. Posterior mediastinal pseudocyst is a different entity associated with acute pancreatitis. In those cases surgery is not recommended. Our third conclusion is that pancreatic tissue should be actively sought, if a structure resembling a pseudocyst is found in an unexpected location.

Virtual slides

The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1849369005957671
Adjuvant zoledronic acid therapy for patients with early stage breast cancer: an updated systematic review and meta-analysis
Authors: He Mingfeng , Fan Weidong , Zhang Xianquan 
Published: October 2013

Abstract

Background
Zoledronic acid is a potent inhibitor of osteoclast-mediated bone resorption and has been widely used in bone metastasis malignancies and postmenopausal osteoporosis as a preventive therapy against skeletal-related events. The purpose of this study was to evaluate the clinical outcome of zoledronic acid as an adjuvant therapy for patients with early stage breast cancer.

Patients and methods
Entries in the PubMed and EMBASE databases up to 12 July 2013 were systematically reviewed. Online abstracts from the proceedings of the Annual Meetings of the American Society of Clinical Oncology (ASCO) (1992–2013) and the San Antonio Breast Cancer Symposium (SABCS) (2004–2013) were also reviewed. Primary endpoints included overall survival (OS) and disease-free survival (DFS), while secondary endpoints included bone metastasis-free survival (BMFS), distant metastasis-free survival (DMFS), and fracture-free rate (FFR).

Results
A total of eight studies including 3,866 subjects and 3,864 controls met our search criteria and were evaluated. The use of zoledronic acid was found to improve OS (relative risk (RR), 0.88; 95% confidence interval (CI), 0.77–1.01; p- value = 0.06) and DMFS (RR, 0.77; 95% CI, 0.60–1.00; p- value = 0.05). Furthermore, statistically significant benefits were associated with BMFS (RR, 0.81; 95% CI, 0.66–0.99; p- value = 0.04) and FFRs (RR, 0.75; 95% CI, 0.61–0.92; p- value = 0.007). In contrast, there was no significant difference in DFS with the application of zoledronic acid (RR, 0.88; 95% CI, 0.72–1.09; p- value = 0.24). Sensitivity analysis further identified the improvement of 5-year OS for the adjuvant zoledronic acid therapy in early stage breast cancer patients (RR, 0.86; 95% CI, 0.75–0.99; p- value = 0.03), while a borderline statistically significant benefit was observed for 5-year DFS (RR, 0.90; 95% CI, 0.81–1.00; p- value = 0.06).

Conclusion
Zoledronic acid as an adjuvant therapy appears to improve the 5-year OS rate for early stage breast cancer patients, and was associated with a protective effect for the bone metastases and fractures evaluated in more than 7,000 patients. However, further research is needed to confirm our findings, and sub-group analyses according to menopause status or hormone status may provide further insight.
Case Article—Process Control and Design of Experiments/ANOVA
Authors: Mirchandani Prakash 
Published: October 2013

Process control and design of experiments are two important concepts that business students must learn, as a proper usage of these techniques can have a significant impact on a firm's bottom line. Moreover, these ideas can be successfully used in a variety of application contexts: Process control applications range from the manufacturing of automobiles to the management of call centers, whereas design of experiments is used for process, product, and policy design. This set of two cases discusses operational improvement initiatives using these methods at a fictitious semiconductor manufacturing company that is being pressured by one of its major customers to improve quality. The first of the two cases covers process control charts, process capability, and a trade-off analysis between product quality improvement and new equipment leasing costs. The second case covers design of experiments and analysis of variance (ANOVA). Both cases require hands-on analysis and can be used in both undergraduate and graduate business programs. Case Teaching Note: Interested Instructors please see the Instructor Materials page for access to the restricted materials. To maintain the integrity and usefulness of cases published in ITE, unapproved distribution of the case teaching notes and other restricted materials to any other party is prohibited.
Case Article—Vermillion OVA1 Test
Authors: Tilson Vera 
Published: October 2013

Tying classroom material to current business events helps motivate and engage students. It also exposes them to examples of how to apply what they learn in practice. We present an example of how, in a course on modeling with spreadsheets, we used or article in The Wall Street Journal (WSJ) about approval of a medical test as the basis for an exercise on conditional probabilities, conflicting objectives, and the value of information. We present the plan of the discussion followed in class and the exercises assigned to students to help them understand the concepts. We use spreadsheet functions and tools new to many of our students, in particular, lookup functions and tools for sensitivity analysis. We also demonstrate how to create and interpret a tornado chart. We believe that examining the WSJ article in detail has value because it allows students to solidify their understanding of conditional probabilities and spreadsheet modeling and also gives them an appreciation of the complexities and the balancing of multiple perspectives in medical decision making. Case Teaching Note: Interested Instructors please see the Instructor Materials page for access to the restricted materials. To maintain the integrity and usefulness of cases published in ITE, unapproved distribution of the case teaching notes and other restricted materials to any other party is prohibited.
Equilibrium Discovery and Preopening Mechanisms in an Experimental Market
Authors: Biais Bruno , Bisière Christophe , Pouget Sébastien 
Published: October 2013

We experimentally analyze how to design preopening mechanisms facilitating coordination on high equilibrium liquidity and gains from trade. We allow a call auction to be preceded by a preopening or not, preopening orders to be binding or not, and the opening time to be deterministic or random. When the preopening is nonbinding, traders place manipulative orders, reducing the credibility of preplay communication. Random market opening deters manipulation, but also hinders communication by making it costly. Gains from trade are maximized when preopening orders are binding. This enables some traders to place early limit orders, attracting further liquidity.Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2013.1787 .This paper was accepted by Wei Xiong, finance.
Truthful Generalized Assignments via Stable Matching
Authors: Chen Ning , Gravin Nick , Lu Pinyan 
Published: October 2013

In the generalized assignment problem (gap), a set of jobs seek to be assigned to a set of machines. For every job-machine pair, there are a specific value and an accommodated capacity for the assignment. The objective is to find an assignment that maximizes the total sum of values given that the capacity constraint of every machine is satisfied. The gap is a classic optimization problem and has been studied extensively from the algorithmic perspective. Dughmi and Ghosh [Dughmi S, Ghosh A (2010) Truthful assignment without money. ACM Conf. Electronic Commerce (ACM, New York), 325–334.] proposed the game theoretical framework in which every job is owned by a selfish agent who aims to maximize the value of his own assignment. They gave a logarithmic approximation truthful in expectation mechanism and left open the problem whether there exists a truthful mechanism with a constant approximation factor. In this paper, we give an affirmative answer to this question and provide a constant approximation mechanism that enjoys a stronger incentive property of universal truthfulness than that of truthfulness in expectation. Our mechanism is inspired by stable matching, which is a fundamental solution concept in the context of matching marketplaces. The mechanism uses a stable matching algorithm as a critical component and adopts other approaches like random sampling.
Governing Hajj: Politics of Islamic Pilgrimage Services in Indonesia Prior to Reformasi Era
Authors: Ichwan Moch Nur 
Published: October 2013

This article highlights that the hajj (Islamic pilgrimage to Mecca) involves not only religious devotion, but also religious tourism and its associated business, necessary to deal with massive parties of pilgrims, embracing trans-national relations, central and local governments, flight and other travel agencies, pilgrimage guidance units, catering agencies and hotels to the pilgrims themselves in its scope. The aim of this article is to analyse the politics of hajj services, which was carried out mainly through the placing of this pilgrimage under government control, leading to the assumption of its monopoly by the government during the New Order period. Although it will focus on Soeharto period, there will be some discussions on this subject during the colonial and early post-colonial periods to trace the genealogy of government control of hajj pilgrimage (and ‘umrah, known also as ‘small hajj’), especially during the New Order. The author argues that the complexities of hajj (and ‘umrah) services were not so much caused by religious aspect but rather by political and economic motives.
Islam in Provincial Indonesia: Middle Class, Lifestyle, and Democracy
Authors: Hasan Noorhaidi 
Published: October 2013

Islamic symbols have flourished in the public spaces of Indonesian provincial towns after Suharto. This phenomenon has occurred in parallel with the significant shifts in the social, economic and political fields, which is tied to the mounting impact of Islamization, social mobility, economic growth, and democratization occurring among town people. It is as if we see a parallel move between Islamization, modernization, globalization and democratization. Key concepts associated with these trends are appropriated with those rooted in tradition and local culture to inform the whole dynamics of Indonesian provincial towns today. The key player in this process is the new middle class, who look to Islam for inspiration both to claim distinction and social status and to legitimize their consumptive lifestyle. They are newly pious who act as active negotiators between the global and the local as well as the cosmopolitan centre and the hinterland. They also play a pivotal role as an agency that liberalizes religion from its traditionally subservient, passive and docile posture by turning it into a source of moral legitimacy and distinction to represent a modern form of life. Given its intimate relationship with locality, tradition, modernity as well as globalization, Islam has increasingly assumed a greater importance for local politics. Political elites have used Islamic symbols for the instrumental purpose of extending their political legitimacy and mobilizing constituency support, in a political environment of open competition and increased public participation in decision making. In this process religious symbols have irrefutably been distanced from their religious moorings and narrow, Islamist understandings, in favor of pragmatic political purposes.
Piety, Politics, and Post-Islamism: Dhikr Akbar in Indonesia
Authors: Hasan Noorhaidi 
Published: October 2013

<p>Dhikr akbar has developed into a performance that provides the opportunity for the sharing of political ideas, thus helping to constitute and negotiate a new public sphere. It is one of the most remarkable developments in the public visibility of Islam in post-Suharto Indonesia. Involving reflexive actions which are significant in the construction of personal and social identity, the dhikr akbar has the ability to silently invoke relations, actions, symbols, meanings and codes, and also to bind in one symbolic package changing roles, statues, social structures and ethical and legal rules. An active religiosity which takes the form of peaceful, esoteric expressions, the dhikr akbar represents a new sense of piety. To some extent, it can be conceptualized as an alternative to religious fundamentalism, an outward-oriented activism tempted to change the society or existing system with one based on religion. Normally performed in a cultural space which attracts public esteem, it serves as a concentrated moment of communality and expression of a community’s faith and, at the same time, a means of empowering political, social and economic networks.</p><p>[Dhikr Akbar berkembang menjadi ‘panggung’ di mana gagasan politik dapat disemai, karena itu berperan dalam mengokohkan dan menegosiasi ruang publik baru. Dhikr Akbar adalah salah satu bentuk ritual Islam di ruang publik yang berkembang pasca Orde Baru. Melalui aktifitas reflektif yang berperan dalam pembentukan identitas personal dan sosial, dhikr akbar mampu memunculkan relasi, aksi, simbol, makna, dan kode, sekaligus untuk mempertemukan kesemuanya dalam satu bentuk simbol peran yang berubah, status, struktur sosial, dan etika serta aturan hukum. Sebagai satu bentuk religiusitas aktif yang berbentuk corak Islam yang tenang dan berorientasi pada dimensi dalam-esoteris, dhikr akbar dapat disebut pula sebagai satu bentuk kesalehan baru. Bentuk kesalehan dapat juga merupakan bentuk keagamaan yang berbeda dengan fundamentalisme, yang berorientasi pada aktifisme dimensi luar dengan tujuan merubah masyarakat atau sistem yang berlaku dengan sistem yang dianggap Islami. Dhikr akbar yang biasanya diselenggarakan di ruang budaya menarik perhatian masyarakat. Kegiatan ini menjadi aktifitas yang mampu menyatukan komunalitas dan ekspresi agama serta pada saat yang sama, mempertemukan jaringan politik, sosial, dan ekonomi.</p>
Crosstalk of lipid and protein homeostasis to maintain membrane function
Authors: Stordeur Claudius , Puth Kristina , Sáenz James P. , Ernst Robert 
Published: October 2013

Abstract
Biological membranes are a defining feature of cellular life. They serve as selective diffusion barriers, compartmentalize biochemical processes and protect the cellular milieu. We are only beginning to understand the principles underlying their homeostasis and the functional relevance of their complex compositions. Here, we summarize some recent evidences that suggest an intense crosstalk between the pathways of protein quality control and lipid homeostasis. We discuss paradigms of lipid regulation by protein degradation machineries and highlight the intricate connections between lipid droplet morphology, membrane biogenesis and ER-stress.
Noninner automorphisms of order p for finite p-groups of coclass 2
Authors: Abdollahi Alireza , Ghoraishi Seyed Mohsen , Guerboussa Yassine , Reguiat Miloud , Wilkens Bettina 
Published: October 2013

Abstract.
Every finite p-group of coclass 2 has a noninner automorphism of order p leaving the center elementwise fixed.
Impact of Molecular Alterations and Targeted Therapy in Appendiceal Adenocarcinomas
Authors: Raghav Kanwal P.S. , Shetty Aditya V. , Kazmi Syed M.A. , Zhang Nianxiang , Morris Jeffrey , Taggart Melissa , Fournier Keith , Royal Richard , Mansfield Paul , Eng Cathy , Wolff Robert A. , Overman Michael J. 
Published: October 2013

Abstract

Background.
Appendiceal adenocarcinomas (AAs) are rare and this has limited their molecular understanding. The purpose of our study was to characterize the molecular profile of AA and explore the role of targeted therapy against cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR).

Patients and Methods.
We performed a retrospective review of 607 patients with AA at a single institution. A total of 149 patients underwent molecular testing for at least one of the following: activating mutations in KRAS, BRAF, cKIT, EGFR, or PI3K; protein expression of c-KIT or COX-2; or microsatellite instability (MSI) status by immunohistochemistry. Kaplan-Meier product limit method and log-rank test were used to estimate overall survival (OS) and to determine associations among OS, COX-2 expression, KRAS mutations, and other characteristics.

Results.
Age, grade, stage, signet ring cells, mucinous histology, and completeness of cytoreduction score correlated with survival outcomes. COX-2 expression, KRAS, PI3K, and BRAF mutations were seen in 61%, 55%, 17%, and 4% of patients, respectively. High MSI was seen in 6% of patients. KRAS mutation was strongly associated with well differentiated or moderately differentiated AA (p &lt; .01). COX-2 expression (p = .33) and the presence of KRAS mutation (p = .91) had no impact on OS. The use of celecoxib in patients whose tumors expressed COX-2 (p = .84) and the use of cetuximab or panitumumab in patients with KRAS wild-type tumors (p = .83) also had no impact on OS.

Conclusion.
In this cohort, we demonstrated that COX-2 expression and KRAS mutations were frequently seen in AA, although neither exhibited any prognostic significance. MSI was infrequent in AA. Targeted therapy against COX-2 and EGFR appeared to provide no clinical benefit. Well and moderately differentiated AA were molecularly distinct from poorly differentiated AA.
Altered Antigenic Profiling and Infectivity of Porphyromonas gingivalis in Smokers and Non‐Smokers With Periodontitis
Authors: Zeller Iris , Hutcherson Justin A. , Lamont Richard J. , Demuth Donald R. , Gumus Pinar , Nizam Nejat , Buduneli Nurcan , Scott David A. 
Published: October 2013

Background: Cigarette smokers are more susceptible to periodontal diseases and are more likely to be infected with Porphyromonas gingivalis than non‐smokers. Furthermore, smoking is known to alter the expression of P. gingivalis surface components and compromise immunoglobulin (Ig)G generation. The aim of this study is to evaluate whether the overall IgG response to P. gingivalis is suppressed in smokers in vivo and whether previously established in vitro tobacco‐induced phenotypic P. gingivalis changes would be reflected in vivo.Methods: The authors examined the humoral response to several P. gingivalis strains as well as specific tobacco‐regulated outer membrane proteins (FimA and RagB) by enzyme‐linked immunosorbent assay in biochemically validated (salivary cotinine) smokers and non‐smokers with chronic periodontitis (CP: n = 13) or aggressive periodontitis (AgP: n = 20). The local and systemic presence of P. gingivalis DNA was also monitored by polymerase chain reaction.Results: Smoking was associated with decreased total IgG responses against clinical (10512, 5607, and 10208C; all P <0.05) but not laboratory (ATCC 33277, W83) P. gingivalis strains. Smoking did not influence IgG produced against specific cell‐surface proteins, although a non‐significant pattern toward increased total FimA‐specific IgG in patients with CP, but not AgP, was observed. Seropositive smokers were more likely to be infected orally and systemically with P. gingivalis (P <0.001), as determined by 16S RNA analysis.Conclusion: Smoking alters the humoral response against P. gingivalis and may increase P. gingivalis infectivity, strengthening the evidence that mechanisms of periodontal disease progression in smokers may differ from those of non‐smokers with the same disease classification.