bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversion of chronic to episodic migraine in working age and botulinum toxin‐resistant patients treated with fremanezumab: A real‐life study
Authors: Tudela‐Tomas Juan , Ramos‐Guerrero Rosa‐Maria , Rodriguez‐Mateos Maria‐Eugenia 
Published: July 2024

AbstractObjectivesThe objectives of this real‐life study were to analyze the reversion of chronic migraine (CM) to episodic migraine (EM) with fremanezumab, evaluate its benefit on the symptomatology, and determine the influence of possible clinical features on the reversion.BackgroundThe clinical manifestations of CM have a high impact on the quality of life of patients, and monoclonal antibodies such as fremanezumab are used as prophylactic treatment.MethodsDiagnosed CM patients treated for at least 3 months with monthly fremanezumab were interviewed. The data to assess efficacy were before treatment and at the time of the interview: monthly headache days (MHDs), daily headache hours (DHHs), monthly symptomatic medication days (MSMDs), percentage of patients with symptomatic medication overuse (SMO), and pain intensity with the numerical rating scale (NRS) score. Possible predictors of reversion were analyzed: percentage of patients treated for at least 12 months, hypertension, diabetes mellitus, depression, anxiety, symptomatic control with non‐steroidal anti‐inflammatory drugs (NSAIDs), triptans or both, and amitriptyline prophylaxis.ResultsA total of 54 patients were included, of whom 40 (74.1%) were converters to EM. There were significant improvements in converters compared to pre‐treatment in MHDs (28.0 vs. 5.0 days), as well as on the variables DHHs, MSMDs, and SMO. The percentage of erenumab failures was significantly higher in non‐converters than in converters, as was the percentage of patients with anxiety.ConclusionsHigh reversion from CM to EM was achieved with fremanezumab and notable symptomatological improvement, establishing previous failure to erenumab and anxiety as possible detrimental factors for reversion.
Development and validation of a nomogram for major adverse cardiovascular events after chronic total occlusion percutaneous coronary intervention for ischemic heart failure
Authors: Du Jiaqi , Yang Lulu , Hao Zhengyang , Li Huan , Yang Chunlei , Wang Xing , Zhang Zhaozhi , Du Youyou , Zhang Yanzhou 
Published: July 2024

AbstractBackgroundChronic total occlusion percutaneous coronary intervention (CTO‐PCI) is an available means of revascularization in patients with ischemic heart failure (IHF). However, the prognosis of IHF patients undergoing CTO‐PCI remains unclear due to the lack of reliable clinical predictive tools.AimThis study aimed to establish a nomogram for major adverse cardiovascular events (MACE) after CTO‐PCI in IHF patients.MethodsSixty‐seven potential predictive variables for MACE in 560 IHF patients undergoing CTO‐PCI were screened using least absolute shrinkage and selection operator regression. A nomogram was constructed based on multivariable Cox regression to visualize the risk of MACE, and then evaluation was carried out using the concordance index (C‐index), time‐independent receiver operating characteristic (timeROC) curves, calibration curves, and decision curve analysis (DCA).ResultsDuring a median follow‐up of 32.0 months, there were 208 MACE occurrences. Seven variables were selected for nomogram construction: age, left ventricular ejection fraction, left ventricular end‐diastolic diameter, N‐terminal precursor B‐type diuretic peptide, bending, and use of intravascular ultrasound and beta‐blockers. The C‐index was 0.715 (0.680–0.750) and the internal validation result was 0.715 (0.676–0.748). The timeROC area under the curve at 6 months, 1 year, and 2 years was 0.750 (0.653–0.846), 0.747 (0.690–0.804), and 0.753 (0.708–0.798), respectively. The calibration curves and DCA showed the nomogram had acceptable calibration and clinical applicability.ConclusionsWe developed a simple and efficient nomogram for MACE after CTO‐PCI in IHF patients, which helps in early risk stratification and postoperative management optimization.
Transcatheter pulmonary valve replacement after arterial switch operation
Authors: Nageotte Stephen , Salavitabar Arash , Zablah Jenny E. , Ligon R. Allen , Turner Mariel E. , El‐Said Howaida , Guyon Peter , Boucek Dana , Alvarez‐Fuente Maria , McElhinney Doff B. , Balzer David , Shahanavaz Shabana 
Published: July 2024

AbstractBackgroundPatients with d‐transposition of the great arteries (d‐TGA) who have undergone an arterial switch operation (ASO) can develop right ventricular outflow tract (RVOT) dysfunction with pulmonary regurgitation (PR) or stenosis. In these patients, treatment may include transcatheter pulmonary valve replacement (TPVR). Coronary compression is a contraindication occurring in 5% of typical TPVR cases. After ASO, there are various anatomical considerations that can confound TPVR, including potential coronary artery compression. Our goal is to understand feasibility of TPVR in patients following ASO.MethodsThis was a retrospective multicenter cohort study of patients with RVOT dysfunction after ASO who underwent cardiac catheterization with intention to perform TPVR from 2008 to 2020.ResultsAcross nine centers, 33 patients met inclusion criteria. TPVR was successful in 22 patients (66%), 19 receiving a Melody valve and 3 a SAPIEN valve. RVOT stenosis in isolation or with PR dictated need for TPVR in nearly all patients. One serious adverse event occurred with valve embolization. After TPVR, the RVOT peak gradient decreased from 43 to 9 mm Hg (p < 0.001); PR was trivial/none in all but one patient, in whom it was mild. Coronary compression prohibiting TPVR occurred in eight patients (24%) and two patients (6%) had severe aortic regurgitation from aortic root deformation precluding TPVR. Seven patients underwent RVOT reintervention a median of 5.3 years post‐TPVR.ConclusionsTPVR in patients with d‐TGA after ASO is feasible, but in this cohort, coronary compression or aortic root distortion precluded TPVR in one‐third of patients. The rate of RVOT reintervention after TPVR was higher in this cohort of ASO patients than in prior studies.
Understanding the role of the left atrial appendage on the flow in the atrium
Authors: Bshennaty Ahmad , Vogl Brennan J. , Bavo Alessandra Maria , Sularz Agata , Kramer Anders Dahl , Jia Yuheng , De Beule Matthieu , Nielsen‐Kudsk Jens Erik , De Backer Ole , Alkhouli Mohamad , Hatoum Hoda 
Published: July 2024

AbstractBackgroundThe exclusion/occlusion of the left atrial appendage (LAA) is a treatment option for atrial fibrillation (AF) patients who are at high risk of stroke and high risk of bleeding. As the role of the LAA is not well understood or explored, this study aims to assess its role on flow dynamics in the left atrium.MethodsComputational fluid dynamics (CFD) simulations were carried out for nine AF patients before and after LAA exclusion. The flow parameters investigated included the LA velocities, Time Averaged Wall Shear Stress (TAWSS), Oscillatory Shear Index (OSI), Relative Residence Time (RRT), and Pressure in the LA.ResultsThis study shows that, on average, a decrease in TAWSS (1.82 ± 1.85 Pa to 1.27 ± 0.96 Pa, p < 0.05) and a slight increase in OSI (0.16 ± 0.10 to 0.17 ± 0.10, p < 0.05), RRT (1.87 ± 1.84 Pa−1 to 2.11 ± 1.78 Pa−1, p < 0.05), and pressure (−19.2 ± 6.8 mmHg to −15.3 ± 8.3 mmHg, p < 0.05) were observed in the LA after the exclusion of the LAA, with a decrease in low‐magnitude velocities.ConclusionThe exclusion of the LAA seems to be associated with changes in LA flow dynamics. Further studies are needed to elucidate the clinical implications of these changes.
In‐stent restenosis caused by a reprotruding calcified nodule and stent fracture in the hinged coronary artery
Authors: Murakami Tsukasa , Kojima Keisuke , Jinnouchi Hiroyuki , Takenoya Masanori 
Published: July 2024

AbstractCalcified nodules (CNs) cause in‐stent restenosis (ISR) frequently. Although reprotrusion of CNs through stent struts is one of the mechanisms of ISR, the process of this phenomenon has not been understood. Furthermore, little is known about stent fracture (SF) occurring at the site of CNs. We are presenting a case of an 82‐year‐old male who developed early ISR due to the combination of an in‐stent CN and SF in the hinged right coronary artery. The process of progression of the in‐stent CN was recorded sequentially with angiography and intravascular ultrasound (IVUS). IVUS from the fulcrum of hinge motion revealed the repetitive protruding movement of the CN into the stent lumen.
Meta‐long Papyrus: Meta‐analysis of mid to long‐term outcomes of PK Papyrus covered stent
Authors: Jurado‐Román Alfonso , Tébar‐Márquez Daniel , Hernandez‐Enríquez Marco , Birkemeyer Ralf , Rodríguez‐Leor Oriol , Spinu Radu , Belle Loïc , Galeote Guillermo , Jiménez‐Valero Santiago , Moreno Raúl 
Published: July 2024

AbstractBackgroundAlthough covered stents (CS) represent a potentially life‐saving intervention for coronary perforation (CAP), their application has expanded to other contexts, including coronary aneurysms (CAA). However, data regarding mid‐ and long‐term outcomes of CS in these settings scenarios remains limited.AimsThis meta‐analysis aims to evaluate major adverse cardiac events (MACE) from discharge through long‐term follow‐up in patients undergoing percutaneous coronary intervention with the new generation polyurethane‐covered cobalt‐chromium PK Papyrus CS.MethodsWe conducted a meta‐analysis of data from three observational trials that included long‐term follow‐up of patients who underwent PK Papyrus CS implantation: Papyrus‐Spain, SOS PK Papyrus, and PAST‐PERF registry.Results332 patients underwent PK Papyrus CS implantation, 236 (71.1%) for CAP, 70 (21.1%) for CAA and 26 (7.8%) for other indications. After a mean follow‐up of 16.2 months, the MACE was 14.3%, with Target Lesion Revascularization (TLR) being the most frequent (8.5%), followed by stent thrombosis (ST), 3.3% and cardiac death (CD), 2.6%. Comparing CAP and CAA subgroups, the MACE rate in CAA was significantly higher than CAP (21.4% vs 9.7%, p < 0.01), primary driven by ST (CAA: 8.6% vs CAP: 1.3%; p = 0.0015).ConclusionsThe clinical outcomes following PK Papyrus CS implantation are deemed acceptable, considering the challenging scenarios and the existing alternative treatments. However, MACE rates in patients with CAA who received Papyrus PK CS were significantly higher than in those with CAP, underscoring the importance of meticulous patient selection and optimization of CS in these complex patients and coronary anatomies.
Real‐Time Product Detection during CO2 Electroreduction on SCILL‐Modified Cu Catalysts
Authors: Parada Walter A. , Mayrhofer Karl J. J. , Nikolaienko Pavlo 
Published: July 2024

AbstractModifying the chemical environment of active surfaces with ionic liquids (IL) is an emerging strategy for tailoring novel electrocatalytic systems, including carbon dioxide reduction (CO2RR). Although copper (Cu) catalysts have recently gained more attention in this field, their modification with ILs is yet to be investigated. This work tested a range of common hydrophobic ILs impregnated into carbon‐supported Cu catalysts, following the “solid catalyst with ionic liquid layer” (SCILL) approach. The latter was used to showcase the applicability of real‐time product detection for CO2RR employing electrochemical mass spectrometry. The observed patterns of C1 to C3 product selectivity offered valuable insights into the intricate reaction mechanism. In addition, increasing the size of the IL cation showed an opposite and significant effect on the reaction selectivity. The obtained qualitative results were partially compared with conventional long‐term experiments.
The Quest for Stable Borozene Core in Main‐Group Capped Inverse Sandwich Complexes, [(HE)2B6H6]2− (E=B, Al, Ga, In, and Tl)
Authors: Joshi Gaurav , Jemmis Eluvathingal D. 
Published: July 2024

AbstractThe ubiquitous chemistry of benzene led us to explore ways to stabilise analogous borozene, by capping them with appropriate groups. The mismatch in overlap of ring‐cap fragment molecular orbitals in [(HB)2B6H6]2− is overcome by replacing the two BH caps with higher congeners of boron. We calculated the relative energies of all the polyhedral structural candidates for [(HE)2B6H6]2− (E=Al−Tl) and found hexagonal bipyramid (HBP) to be more stable with Al−H caps. A global minimum search also gives HBP as the most stable structure for [Al2B6H8]2−. The capped B6H6 ring in [(HAl)2B6H6]2− has aromaticity comparable to that of benzene.
Prostate cancer in transgender women: A propensity score–matched analysis of disease severity and survival
Authors: Meagher Margaret , Morgan Kylie , Deshler Leah , Riviere Paul , Dolendo Isabella , Rose Brent , Jamieson Christina , Morris Sheldon , Nik‐Ahd Farnoosh , Freedland Stephen , Anger Jennifer , Salmasi Amirali 
Published: July 2024

AbstractBackgroundDespite the rise in gender‐affirming care, our understanding of prostate cancer (PCa) in transgender women (TGW) remains in its infancy. Health disparities and lack of PCa awareness and screening are possible barriers to providing quality care for this population. In addition, the implication of hormonal manipulation for the aggressiveness of PCa in TGW is yet to be determined. Here, this study sought to compare oncological characteristics and survival outcomes between transgender and cisgender (CG) patients with PCa via two national data sets.MethodsThe Veterans Affairs Informatics and Computing Infrastructure database (1999–2020) and the Surveillance, Epidemiology, and End Results–Medicare database (2010–2017) were reviewed. Demographic and clinical details were analyzed. Logistic regression analysis was performed on propensity score–matched groups to identify predictors of high‐risk disease and metastasis in patients with PCa. Groups were matched 5:1 (CG:TGW) on the basis of age, race, year of diagnosis, and Charlson Comorbidity Index score. Primary outcomes included metastatic presentation, high‐risk localized disease, overall survival (OS), and prostate cancer–specific mortality (PCSM).ResultsA total of 1194 patients were included (199 TGW; 995 CG). Associations between transgender identity and metastatic presentation (odds ratio [OR], 0.38; p = .2), high‐risk localized disease (OR, 1.19; p = .50), or PCSM (hazard ratio [HR], 0.65; p = .3) were not detected. Transgender identity was associated with improved OS (HR, 0.67; p = .014).ConclusionsPCa‐specific outcomes seem comparable between TGW and CG men, although the study was underpowered to detect modest differences. Further investigation into the incidence and outcomes of PCa in TGW is warranted.
Comparison of infection risk between enzalutamide and abiraterone in patients with prostate cancer
Authors: Lee Yan Hiu Athena , Chan Jeffrey Shi Kai , Leung Chi Ho , Liu Alex Qinyang , Dee Edward Christopher , Ng Kenrick , Shamash Johnathan , Tse Gary , Wai Leung David Ka , Ng Chi Fai 
Published: July 2024

AbstractBackgroundEnzalutamide and abiraterone may differ in their immunomodulatory effects, and the prednisone coadministered with abiraterone can be immunosuppressive. This study aimed to compare the risk of different types of infection in patients with prostate cancer receiving enzalutamide or abiraterone in combination with androgen deprivation therapy.MethodsPatients with prostate cancer receiving enzalutamide or abiraterone in addition to androgen deprivation therapy in Hong Kong between December 1999 to March 2021 were identified in this retrospective cohort study and followed up until September 2021, death, or crossover. Outcomes, including any sepsis, pneumonia, urinary tract infection, cellulitis or skin abscess, central nervous system infections, and tuberculosis, were analyzed as both time‐to‐event outcomes (multivariable Fine‐Gray regression, with mortality considered a competing event) and recurrent‐event outcomes (multivariable negative binomial regression).ResultsAltogether, 1582 patients were analyzed (923 abiraterone users; 659 enzalutamide users) with a median follow‐up of 10.6 months (interquartile range: 5.3–19.9 months). Compared to abiraterone users, enzalutamide users had lower cumulative incidences of sepsis (adjusted subhazard ratio [SHR] 0.70 [0.53–0.93], p = .014), pneumonia (adjusted SHR 0.76 [0.59–0.99], p = .040), and cellulitis or skin abscess (adjusted SHR 0.55 [0.39–0.79], p = .001), but not urinary tract infection (adjusted SHR 0.91 [0.62–1.35], p = .643). Associations between exposure and central nervous system infections and tuberculosis were not assessed because of low event rates. Analyzing the outcomes as recurrent events gave similar results. Enzalutamide use may be associated with a lower risk of urinary tract infection in patients with diabetes mellitus.ConclusionsCompared to abiraterone users, enzalutamide users have significantly lower risks of sepsis, pneumonia, cellulitis, or skin abscess.
Effect of Psychotherapy on Intolerance of Uncertainty: A Systematic Review and Meta‐Analysis
Authors: Näsling John , Åström Elisabeth , Jacobsson Lars , Ljungberg Jessica K. 
Published: July 2024

ABSTRACTIntolerance of uncertainty (IU) is the tendency to react negatively on affective, cognitive and behavioural levels to uncertain situations and to harbour negative beliefs about the implications of uncertainty. IU has been linked to psychopathology and shown to impact treatment outcomes. This study systematically reviewed the literature and performed a meta‐analysis of the effects of psychotherapy on IU. A total of 22 studies (1491 participants) were identified in online searches and included in the meta‐analyses. Analyses were performed on studies with passive and active control conditions. The pooled effect on IU from studies with passive control was large (g = −0.94 [95% CI −1.25 to −0.62]) but with significant heterogeneity. Pooled effects on IU from studies with active controls were not significant. Moderator analysis showed that among studies with a passive control condition, studies that recruited participants from clinical care facilities produced smaller effect sizes. Among studies with an active control condition, study quality significantly moderated the results, with higher quality leading to a larger effect size. These results indicate that changes in IU may be difficult to reliably achieve in psychotherapy and leave many questions about the effect of psychotherapy on IU unanswered, such as what active components produced the observed changes in studies with passive control.
SDN architecture‐based secure data transfer with cooperative searching scheme for AUV‐based underwater wireless networks
Authors: Vana Hari Krishna , Kolisetty Ramadevi , Narayanam Balaji 
Published: July 2024

SummaryUnderwater wireless sensor networks (UWSNs) based on autonomous underwater vehicles (AUVs) have become the standard technology for underwater search tasks with the advent of new underwater information and communication technologies (ICTs). It is also vulnerable to threats and malicious attacks because of its inherent characteristics, open acoustic channel and hostile underwater environment. The purpose of this research is to develop a secure data transfer (SDF) system based on software‐defined networking (SDN) architecture with cooperative searching scheme (CSS) (SDN‐SDF‐CSS) for AUV‐based UWSN. This part employs data, local control and the primary control layer to provide a scalable SDN‐based architecture for the AUV‐based UWSN. To accomplish the underwater search operation, the data layer is primarily deployed to gather AUVs (G‐AUVs) and store AUVs (S‐AUVs). In order to schedule the AUV, the clustering process takes place based on priority ranking with respect to the average power of each cluster. Then, the CSS is developed, and it is performed in the data layer. The hierarchical localization framework (HLF) can be used to locate each AUV's location within the data layer, which is a necessary step in deploying the cooperative searching model. Finally, for an efficient data transfer, the communication model is deployed in the data layer. UWSNs are vulnerable to various malicious attacks (such as bad‐mouthing attacks, on–off attacks, blackhole attacks and wormhole attacks) because of the high bit error rate and unstable optical/acoustic channels in the underwater environment. To overcome this, an SDF technique is used, which involves isolating the attacker node from the data layer. The suggested SDN‐SDF‐CSS model is implemented on the MATLAB platform, and its performance is evaluated using various evaluation metrics, both with and without attacks. As a result, the proposed SDN‐SDF‐CSS model has achieved better performance and proved its superiority in the UWSN environment.
A miniaturized dual wide‐band polarization reconfigurable antenna integrated with artificial magnetic conductor for next‐generation wireless applications
Authors: Rajavel Vellaichamy , Ghoshal Dibyendu 
Published: July 2024

SummaryIn today's intricate wireless communication environment, ensuring system quality demands the use of a reliable and versatile antenna system. This research article introduces a polarization reconfigurable antenna integrated with a 4 × 4 Artificial Magnetic Conductor (AMC) surface. The AMC unit cell exhibits a triple‐band reflection phase response at 1.8GHz, 4.5GHz, and 5.5GHz, demonstrating double negative metamaterial behavior. The antenna features two distinct C‐shaped metal strips connected to two PIN diodes, enabling dynamic current distribution adjustment. Consequently, the proposed antenna offers three reconfigurable states, facilitating seamless switching between dual circular polarization (left and right‐hand circular polarization) and linear polarization. With a frequency coverage ranging from 1.29 to 2.52GHz and 3.59 to 6.15GHz, the antenna boasts a maximum axial ratio (AR) bandwidth of 31.96%. Additionally, it achieves a maximum peak gain of 5.5 dB and maintains front‐to‐back ratio (FBR) values exceeding 25 dB, while recording a minimum specific absorption rate (SAR) value of 0.1059 W/kg. The integration of the AMC surface ensures enhanced performance of the antenna. Experimental results from constructed prototypes closely align with simulation outcomes, validating the effectiveness of the proposed antenna. Consequently, this antenna holds significant promise for next‐generation wireless applications.