bluuebunny/crossref_metadata_2025_split huggingface dataset:
Labelling dendritic cells with SPIO has implications for their subsequent in vivo migration as assessed with cellular MRI
Authors: de Chickera Sonali N. , Snir Jonatan , Willert Christy , Rohani Roja , Foley Ronan , Foster Paula J. , Dekaban Gregory A. 
Published: October 2015

AbstractAn optimized non‐invasive imaging modality capable of tracking and quantifying in vivo DC migration in patients would provide clinicians with valuable information regarding therapeutic DC‐based vaccine outcomes. Superparamagnetic iron oxide (SPIO) nanoparticles were used to label bone marrow‐derived DC. In vivo DC migration was tracked and quantified non‐invasively using cellular magnetic resonance imaging (MRI) in a mouse model. Labelling DC with SPIO reflects the kinetics of DC migration in vivo but appears to reduce overall DC migration, in part due to nanoparticle size. Magnetic separation of SPIO‐labelled (SPIO+) DC from unlabelled (SPIO−) DC prior to injection improves SPIO+ DC migration to the lymph node. Corresponding MR image data better correlate with the presence of DC in vivo; an improved immunological response is also seen. Cellular MRI is a viable, non‐invasive imaging tool that can routinely track DC migration in vivo. Consideration should be given to optimizing MRI contrast agent‐labelling of clinical‐grade DC in order to accurately correlate DC fate to immunological outcomes in patients. Copyright © 2011 John Wiley & Sons, Ltd.
Validation of a short questionnaire to measure symptoms and functional limitations associated with hand‐foot syndrome and mucositis in patients with metastatic renal cell carcinoma
Authors: Lai Jin‐Shei , Beaumont Jennifer L. , Diaz Jose , Khan Sadya , Cella David 
Published: October 2015

BACKGROUNDHand‐foot syndrome and mucositis/stomatitis are frequent adverse events (AEs) of treatment with tyrosine kinase inhibitors in cancer therapy. Quality‐of‐life instruments that measure the functional consequences of these AEs are needed to assess the impact of therapeutic interventions and to guide patient care. The Hand‐Foot and Mucositis Symptom and Impact Questionnaire (HAMSIQ [formerly the Supplementary Quality of Life Questionnaire]) was used in the COMPARZ trial (Pazopanib vs Sunitinib in the Treatment of Locally Advanced and/or Metastatic Renal Cell Carcinoma [national clinical trial no. NCT00720941]) and the PISCES study (Patient Preference Study of Pazopanib vs Sunitinib in Advanced or Metastatic Kidney Cancer [clinicaltrials.gov NCT01064310]) to assess mouth/throat and hand/foot soreness symptoms and subsequent limitations in patients receiving pazopanib or sunitinib for metastatic renal cell carcinoma. The objective of the current analysis was to validate the HAMSIQ using data from the PISCES study.METHODSThe HAMSIQ was administered in the PISCES study at baseline and every 2 weeks over two 10‐week periods to patients who were receiving pazopanib or sunitinib. Data from the first 10‐week period were used to assess the feasibility, validity, and responsiveness of the HAMSIQ.RESULTSIn total, ≥85% of 169 patients completed the HAMSIQ (excluding the item concerning days off work). Correlations among items within the same limitation subscale generally were high (Cronbach α ≥ .80). HAMSIQ limitation scores differentiated patients according to their baseline performance status and severity of soreness. Small‐to‐moderate correlations were observed for the symptoms/limitation scores and for changes from baseline scores between the HAMSIQ and the Functional Assessment of Chronic Illness Therapy fatigue survey. The HAMSIQ demonstrated responsiveness to changes in clinical status and the development of hand‐foot syndrome AEs over time.CONCLUSIONSThe HAMSIQ is a feasible, valid, reliable, and responsive instrument for assessing the impact of hand‐foot syndrome and mucositis in patients receiving tyrosine kinase inhibitors. Cancer 2016;122:287–295. © 2015 American Cancer Society.
Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in The Bethesda System for Reporting Thyroid Cytopathology
Authors: Faquin William C. , Wong Lawrence Q. , Afrogheh Amir H. , Ali Syed Z. , Bishop Justin A. , Bongiovanni Massimo , Pusztaszeri Marc P. , VandenBussche Christopher J. , Gourmaud Jolanta , Vaickus Louis J. , Baloch Zubair W. 
Published: October 2015

BACKGROUNDRecent discussions have focused on redefining noninvasive follicular variant of papillary thyroid carcinoma (NI‐FVPTC) as a neoplasm rather than a carcinoma. This study assesses the potential impact of such a reclassification on the implied risk of malignancy (ROM) for the diagnostic categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).METHODSThe study consisted of consecutive fine‐needle aspiration biopsy (FNAB) cases collected between January 1, 2013 and June 30, 2014 from 5 academic institutions. Demographic information, cytology diagnoses, and surgical pathology follow‐up were recorded. The ROM was calculated with and without NI‐FVPTC and was presented as a range: all cases (ie, overall risk of malignancy [OROM]) versus those with surgical follow‐up only.RESULTSThe FNAB cohort consisted of 6943 thyroid nodules representing 5179 women and 1409 men with an average age of 54 years (range, 9‐94 years). The combined average ROM and OROM for the diagnostic categories of TBSRTC were as follows: nondiagnostic, 4.4% to 25.3%; benign, 0.9% to 9.3%; atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS), 12.1% to 31.2%; follicular neoplasm (FN), 21.8% to 33.2%; suspicious for malignancy (SM), 62.1% to 82.6%; and malignant, 75.9% to 99.1%. The impact of reclassifying NI‐FVPTC on the ROM and OROM was most pronounced and statistically significant in the 3 indeterminate categories: the AUS/FLUS category had a decrease of 5.2% to 13.6%, the FN category had a decrease of 9.9% to 15.1%, and the SM category had a decrease of 17.6% to 23.4% (P < .05), whereas the benign and malignant categories had decreases of 0.3% to 3.5% and 2.5% to 3.3%, respectfully. The trend of the effect on the ROM and OROM was similar for all 5 institutions.CONCLUSIONSThe results from this multi‐institutional cohort indicate that the reclassification of NI‐FVPTC will have a significant impact on the ROM for the 3 indeterminate categories of TBSRTC. Cancer Cytopathol 2016;124:181–187. © 2015 American Cancer Society.
The clinical performance of primary HPV screening, primary HPV screening plus cytology cotesting, and cytology alone at a tertiary care hospital
Authors: Choi Jung‐Woo , Kim Younghye , Lee Ju‐Han , Kim Young‐Sik 
Published: October 2015

BACKGROUNDAlgorithms for primary human papillomavirus (HPV) screening, primary HPV screening plus cytology cotesting, and cytology alone were evaluated previously in large cohort trials for cervical cancer detection, although the quality of cytology in those studies was controversial. To investigate whether these 3 algorithms would be applicable in routine practice at a tertiary care hospital, the authors compared their clinical performance. In addition, the prevalence of HPV genotypes was determined.METHODSCervical cytology samples (n = 1000) were tested using liquid‐based cytology (LBC), a nucleic acid hybridization assay, real‐time polymerase chain reaction analysis, and direct HPV DNA sequencing. The clinical performance of the 3 algorithms was compared among women in different age groups (age range, 17‐86 years; median age, 44.7 years).RESULTSFor cervical intraepithelial neoplasia grade 2 or worse (CIN 2+), the sensitivity of primary HPV screening alone, cotesting, and LBC alone was 71.7%, 72.5%, and 63.8%, respectively; whereas the specificity was 87.5%, 96.5%, and 97.4%, respectively. Cotesting and LBC alone had slightly higher positive predictive values for CIN 2 + (97.8% and 98.9%, respectively) than primary HPV screening alone (91%), whereas primary HPV screening alone and cotesting demonstrated higher negative predictive values (63.6% and 62.5%, respectively) than LBC alone (43.2%). High‐risk HPV types were detected in 24.3% of individuals. The most common type was HPV type 16 (HPV‐16) followed by multiple HPV infections and HPV‐58, HPV‐52, HPV‐31, HPV‐35, HPV‐51, HPV‐39, HPV‐56, HPV‐33, HPV‐18, HPV‐59, and HPV‐45.CONCLUSIONSPrimary HPV screening alone in a tertiary care hospital demonstrated a performance that was equivalent to that of cotesting for CIN 2+, irrespective of patient age. With regard to the distribution of HPV genotypes, the nonavalent HPV vaccine would prevent approximately 60% of high‐risk HPV. Cancer (Cancer Cytopathol) 2016;124:144–152. © 2015 American Cancer Society.
User applications driven by the community contribution framework MPContribs in the Materials Project
Authors: Huck P. , Gunter D. , Cholia S. , Winston D. , N'Diaye A. T. , Persson K. 
Published: October 2015

SummaryThis work discusses how the MPContribs framework in the Materials Project (MP) allows user‐contributed data to be shown and analyzed alongside the core MP database. The MP is a searchable database of electronic structure properties of over 65,000 bulk solid materials, which is accessible through a web‐based science‐gateway. We describe the motivation for enabling user contributions to the materials data and present the framework's features and challenges in the context of two real applications. These use cases illustrate how scientific collaborations can build applications with their own ‘user‐contributed’ data using MPContribs. The Nanoporous Materials Explorer application provides a unique search interface to a novel dataset of hundreds of thousands of materials, each with tables of user‐contributed values related to material adsorption and density at varying temperature and pressure. The Unified Theoretical and Experimental X‐ray Spectroscopy application discusses a full workflow for the association, dissemination, and combined analyses of experimental data from the Advanced Light Source with MP's theoretical core data, using MPContribs tools for data formatting, management, and exploration. The capabilities being developed for these collaborations are serving as the model for how new materials data can be incorporated into the MP website with minimal staff overhead while giving powerful tools for data search and display to the user community. Copyright © 2015 John Wiley & Sons, Ltd.
MEMoMR: Accelerate MapReduce via reuse of intermediate results
Authors: Yao Hong , Xu Jinlai , Luo Zhongwen , Zeng Deze 
Published: October 2015

SummaryMapReduce has been widely regarded as a flexible, scalable, and easy‐to‐use distributed programming paradigm for big data processing such as social network data analysis on cloud computing platforms. To embrace the upcoming of big data era, many efforts have been devoted to accelerating the MapReduce performance from different aspects, especially intermediate result reusing like Dache. In this paper, we observe that existing intermediate result reusing mechanism is not efficient enough as many I/O operations are wasted. Efficient reusing of the intermediate results could potentially improve the MapReduce performance. Inspired by such fact, we propose a framework named MEMoMR (more efficient intermediate result reusing for MapReduce) by introducing a novel reusing mechanism that can substantially reduce the I/O overhead. To this end, we invent a new metadata description method and apply it in the reusing phase. We practically realize MEMoMR and evaluate its performance by implementing it in a real cluster. The experiment results show that MEMoMR can improve the system performance as high as 23.4%, comparing against Dache. Copyright © 2015 John Wiley & Sons, Ltd.
Academic Achievement of University Students with Dyslexia
Authors: Olofsson Åke , Taube Karin , Ahl Astrid 
Published: October 2015

Broadened recruitment to higher education is on the agenda in many countries, and it is also widely recognized that the number of dyslexic students entering higher education is increasing. In Sweden, as in many other European countries, higher education institutions are required to accommodate students with dyslexia. The present study focuses on the study outcome for 50 students with diagnosed dyslexia, mainly in teacher education and nurses' training, at three universities in Northern Sweden. The students trusted their own ability to find information on the Internet but mistrusted their own abilities in reading course books and articles in English and in taking notes. The mean rate of study was 23.5 European Credit Transfer and Accumulation System credits per semester, which is slightly below the national baseline of 26.7. The results show that more than half of the students are examined at a normal rate of study but that about one fifth have a very low rate of study. Copyright © 2015 John Wiley & Sons, Ltd.Key Messages

Most students with dyslexia can compensate for their reading problems.
Taking notes during lessons and reading in foreign language may be especially difficult for students with dyslexia.
Diagnoses should distinguish between reading comprehension and word decoding.
More than half of the students with dyslexia can achieve at a normal rate of study.
One‐fifth of the students with dyslexia may need a longer period of study than other students.
Cochrane in context: Swimming training for asthma in children and adolescents aged 18 years and under
Authors: Beggs Sean , Walters Julia A. E. 
Published: October 2015

AbstractCochrane Review: Swimming training for asthma in children and adolescents aged 18 years and under Beggs S, Foong YC, Le HCT, Noor D, Wood‐Baker R, Walters JAE. Swimming training for asthma in children and adolescents aged 18 years and under. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD009607. DOI: 10.1002/14651858.CD009607.pub2This companion piece to the review, “Swimming training for asthma in children and adolescents aged 18 years and under,” contains the following pieces:

The abstract of the review
A commentary from one or more of the review authors, explaining why the review team felt the review as an important once to produce
A review of clinical practice guidelines from the American Academy of Pediatrics, the Canadian Paediatric Society and the National Institute for Health and Care Excellence (NICE), United Kingdom
Some other recently published references on this topic
Population and genetic outcomes 20 years after reintroducing bobcats (Lynx rufus) to Cumberland Island, Georgia USA
Authors: Diefenbach Duane , Hansen Leslie , Bohling Justin , Miller‐Butterworth Cassandra 
Published: October 2015

AbstractIn 1988–1989, 32 bobcats Lynx rufus were reintroduced to Cumberland Island (CUIS), Georgia, USA, from which they had previously been extirpated. They were monitored intensively for 3 years immediately post‐reintroduction, but no estimation of the size or genetic diversity of the population had been conducted in over 20 years since reintroduction. We returned to CUIS in 2012 to estimate abundance and effective population size of the present‐day population, as well as to quantify genetic diversity and inbreeding. We amplified 12 nuclear microsatellite loci from DNA isolated from scats to establish genetic profiles to identify individuals. We used spatially explicit capture–recapture population estimation to estimate abundance. From nine unique genetic profiles, we estimate a population size of 14.4 (SE = 3.052) bobcats, with an effective population size (Ne) of 5–8 breeding individuals. This is consistent with predictions of a population viability analysis conducted at the time of reintroduction, which estimated the population would average 12–13 bobcats after 10 years. We identified several pairs of related bobcats (parent‐offspring and full siblings), but ~75% of the pairwise comparisons were typical of unrelated individuals, and only one individual appeared inbred. Despite the small population size and other indications that it has likely experienced a genetic bottleneck, levels of genetic diversity in the CUIS bobcat population remain high compared to other mammalian carnivores. The reintroduction of bobcats to CUIS provides an opportunity to study changes in genetic diversity in an insular population without risk to this common species. Opportunities for natural immigration to the island are limited; therefore, continued monitoring and supplemental bobcat reintroductions could be used to evaluate the effect of different management strategies to maintain genetic diversity and population viability. The successful reintroduction and maintenance of a bobcat population on CUIS illustrates the suitability of translocation as a management tool for re‐establishing felid populations.
Control of a tripedal robot walking with a shuffle
Authors: Torii Akihiro , Ueda Akiteru , Doki Kae 
Published: October 2015

AbstractThis paper describes a control method for a tripedal robot which walks with a shuffle. The robot consists of three electromagnets and three piezoelectric elements. The electromagnet supports the robot as a leg. Two of the three electromagnets adhere to a magnetic floor and the other electromagnet is moved by the deformation of the piezos. The relation between the control waveforms and the robot motion is described theoretically. The theoretical displacement of the robot is calculated. The piezo deformations which move the robot to the destination are obtained. The control waveform is determined by the piezo deformations. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 177(4): 33–41, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21192
First Enantioselective Synthesis of Surinamensinol B and a Non‐Natural Polysphorin Analogue by a Two‐Stereocentered Hydrolytic Kinetic Resolution
Authors: Lalwani Komal G. , Sudalai Arumugam 
Published: October 2015

AbstractAn efficient and economical approach to the synthesis of antitumor and anti‐inflammatory surinamensinol B (1) and antimalarial polysphorin analogue 2 has been achieved with high enantiomeric purity (96 % ee) by starting from commercially available 3,4,5‐trimethoxybenzaldehyde. The key steps of the strategy include a Co‐catalyzed two‐stereocentered hydrolytic kinetic resolution (HKR) of racemic 2‐[(methoxymethoxy)(3,4,5‐trimethoxyphenyl)methyl]oxirane (13) as the chiral inducing step followed by a Mitsunobu reaction. Chiral epoxide 14 and chiral diol 15 were utilized in the syntheses of both compounds.
Predicted transport of pyrethroid insecticides from an urban landscape to surface water
Authors: Jorgenson Brant , Fleishman Erica , Macneale Kate H. , Schlenk Daniel , Scholz Nathaniel L. , Spromberg Julann A. , Werner Inge , Weston Donald P. , Xiao Qingfu , Young Thomas M. , Zhang Minghua 
Published: October 2015

Abstract

The authors developed a simple screening-level model of exposure of aquatic species to pyrethroid insecticides for the lower American River watershed (California, USA). The model incorporated both empirically derived washoff functions based on existing, small-scale precipitation simulations and empirical data on pyrethroid insecticide use and watershed properties for Sacramento County, California, USA. The authors calibrated the model to in-stream monitoring data and used it to predict daily river pyrethroid concentration from 1995 through 2010. The model predicted a marked increase in pyrethroid toxic units starting in 2000, coincident with an observed watershed-wide increase in pyrethroid use. After 2000, approximately 70% of the predicted total toxic unit exposure in the watershed was associated with the pyrethroids bifenthrin and cyfluthrin. Pyrethroid applications for aboveground structural pest control on the basis of suspension concentrate categorized product formulations accounted for greater than 97% of the predicted total toxic unit exposure. Projected application of mitigation strategies, such as curtailment of structural perimeter band and barrier treatments as recently adopted by the California Department of Pesticide Regulation, reduced predicted total toxic unit exposure by 84%. The model also predicted that similar reductions in surface-water concentrations of pyrethroids could be achieved through a switch from suspension concentrate–categorized products to emulsifiable concentrate–categorized products without restrictions on current-use practice. Even with these mitigation actions, the predicted concentration of some pyrethroids would continue to exceed chronic aquatic life criteria. Environ Toxicol Chem 2013;32:2469–2477. © 2013 SETAC
Scaling laws and techniques in decentralised processing of interfered Gaussian channels
Authors: Sanderovich Amichai , Peleg Michael , Shamai (Shitz) Shlomo 
Published: October 2015

ABSTRACTThe scaling laws of the achievable communication rates and the corresponding upper bounds of distributed reception in the presence of an interfering signal are investigated. The scheme includes one transmitter communicating to a remote destination via two relays, which forward messages to the remote destination through reliable links with finite capacities. The relays receive the transmission along with some unknown interference. We focus on three common settings for distributed reception, wherein the scaling laws of the capacity (the prelog as the power of the transmitter and the interference are taken to infinity) are completely characterized. It is shown in most cases that to overcome the interference, a definite amount of information about the interference needs to be forwarded along with the desired message, to the destination. The upper bounds results are derived using the cut‐set along with a new bounding technique, which relies on multiletter expressions. The latter is demonstrated to be useful in a scenario where the cut‐set upper bound happens to be strictly loose. The lower bound results are derived using random‐coding arguments, wherein some interesting cases combining lattices are found to be beneficiary, and used to determine the scaling laws of the achievable rate. Copyright © 2011 John Wiley & Sons, Ltd.
„Wir sind dann mal weg”︁
Authors: Unterstell Rembert 
Published: October 2015

AbstractFaszination Vogelzug: Beflügelt von modernen Forschungsmethoden studieren Ornithologen am Wilhelmshavener Institut für Vogelforschung die inneren und äußeren Mechanismen der jährlichen Wanderungsbewegungen. Ihr neues Modell ist der kleine Steinschmätzer.
Mit Riss, ohne Riss
Authors: Kaliske Michael 
Published: October 2015

AbstractBauteile aus Gummi sind überall – und überall von Abnutzung und Materialermüdung bedroht. Um Reifen, Lager oder Dichtungsringe zuverlässiger und haltbarer zu machen, setzen Ingenieurwissenschaftler bruchmechanische Methoden ein. Zu neuen Erkenntnissen führen insbesondere aufwendige Simulationen.
Tobacco Endgame: The Poverty Conundrum
Authors: Gostin Lawrence O. 
Published: October 2015

AbstractThere is no more striking public health triumph than the demise of the “brown plague.” The cigarette was once the accoutrement of a good life, but smoking is now a tragic habit of the poor. By the mid‐1960s, half of all men and a third of women in the United States smoked. Today the national prevalence is 18 percent, with rates in major cities below 15 percent. A suite of policies drove down smoking rates—antismoking campaigns, taxation, clean air laws, package labeling, and marketing curbs. These policies, and the resultant behavior changes, however, have diminishing returns. Is it possible that tobacco rates will remain relatively stagnant? If so, what “endgame” strategies might drive rates to negligible levels, say, lower than 5 percent? And if society does achieve such an audacious goal, how attentive should it be to the problems of social justice?