bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac magnetic resonance imaging in the evaluation and management of mitral valve prolapse – a comprehensive review
Authors: Mangini Francesco , Scarcia Maria , Biederman Robert W. W. , Calbi Roberto , Spinelli Francesco , Casavecchia Grazia , Brunetti Natale Daniele , Gravina Matteo , Fiore Corrado , Suma Sergio , Milo Maria , Turchetti Cristiano , Pesce Ernesto , Caramia Remo , Lombardi Francesca , Grimaldi Massimo 
Published: July 2024

AbstractMitral valve prolapse is a common valve disorder that usually has a benign prognosis unless there is significant regurgitation or LV impairment. However, a subset of patients are at an increased risk of ventricular arrhythmias and sudden cardiac death, which has led to the recognition of “arrhythmic mitral valve prolapse” as a clinical entity. Emerging risk factors include mitral annular disjunction and myocardial fibrosis. While echocardiography remains the primary method of evaluation, cardiac magnetic resonance has become crucial in managing this condition. Cine magnetic resonance sequences provide accurate characterization of prolapse and annular disjunction, assessment of ventricular volumes and function, identification of early dysfunction and remodeling, and quantitative assessment of mitral regurgitation when integrated with flow imaging. However, the unique strength of magnetic resonance lies in its ability to identify tissue changes. T1 mapping sequences identify diffuse fibrosis, in turn related to early ventricular dysfunction and remodeling. Late gadolinium enhancement sequences detect replacement fibrosis, an independent risk factor for ventricular arrhythmias and sudden cardiac death. There are consensus documents and reviews on the use of cardiac magnetic resonance specifically in arrhythmic mitral valve prolapse. However, in this article, we propose an algorithm for the broader use of cardiac magnetic resonance in managing this condition in various scenarios. Future advancements may involve implementing techniques for tissue characterization and flow analysis, such as 4D flow imaging, to identify patients with ventricular dysfunction and remodeling, increased arrhythmic risk, and more accurate grading of mitral regurgitation, ultimately benefiting patient selection for surgical therapy.
Inflation targeting, output stabilization, and real indeterminacy in monetary models with an interest rate rule
Authors: Platonov Konstantin 
Published: July 2024

AbstractCentral banks set the nominal interest rate to target inflation and stabilize output. In monetary models, monetary policy affects output directly via the wealth effect. I show that in these models, the response of the central bank to fluctuations in output may induce real indeterminacy even if the Taylor principle is satisfied. I find that the determinacy conditions depend on the interest elasticity of output and generally, the Taylor principle is neither necessary nor sufficient for determinacy. This is in stark contrast with the New Keynesian model where a sufficiently strong policy response to inflation or output usually ensures determinacy.
Antiemetic prophylaxis regimens in haematologic malignancies patients undergoing a hematopoietic stem cell transplantation. Which is the best standard of care? A systematic review
Authors: Báez‐Gutiérrez Nerea , Suárez‐Casillas Paloma , Pérez‐Moreno Maria Antonia , Blázquez‐Goñi Cristina , Abdelkader‐Martín Laila 
Published: July 2024

AbstractIntroductionThis systematic review, adhering to PRISMA guidelines, aimed to evaluate the efficacy and safety of antiemetic prophylaxis in haematological patients undergoing high‐dose chemotherapy as part of their hematopoietic stem cell transplantation (HSCT) conditioning regimens.MethodsWe performed a comprehensive search in PubMed, EMBASE, ClinicalTrials.gov and the Cochrane database to identify randomised controlled trials (RCTs) and systematic reviews of antiemetic prophylaxis. Studies in English, French, Italian or Spanish were included. This review is registered with PROSPERO, ID CRD42023406380.ResultsEight RCTs were analysed. The antiemetic regimens evaluated ranged from monotherapy with 5‐Hydroxytryptamine Receptor 3 antagonists (5‐HT3RAs) to complex combinations including olanzapine, neurokinin‐1 receptor antagonists, 5‐HT3RAs and corticosteroids. Complete response rates for triplet or quadruple regimens varied between 23.5% and 81.9%. Although no significant adverse effects were observed, minor symptoms such as diarrhoea, constipation, sedation and headaches were reported.ConclusionExisting evidence on HSCT antiemetic therapy highlights its benefits but fails to provide clear clinical directions. The choice between triplet and quadruplet therapies for different patient scenarios is still uncertain. Until more detailed research is available, healthcare providers must rely on the latest guidelines and their judgement to customise antiemetic care for each patient's specific needs and risks.
Epigenetic mechanisms and oral mucositis in children with acute lymphoblastic leukaemia
Authors: Guimarães Juliana Ramalho , de Souza Beatriz Fernandes , Filho José Maria Chagas Viana , Damascena Lecidamia Cristina Leite , Valença Ana Maria Gondim , Persuhn Darlene Camati , de Oliveira Naila Francis Paulo 
Published: July 2024

AbstractThis study aimed to investigate the relationship between epigenetic mechanisms and oral mucositis (OM) in paediatric patients with acute lymphoblastic leukaemia. Oral cells were collected from 76 participants, including 15 healthy individuals, 10 patients with acute lymphoblastic leukaemia but without a history of OM and 51 acute lymphoblastic leukaemia patients with a history of OM (35 with active OM and 16 who had recovered from OM). Global DNA methylation in the miR‐9‐1 and miR‐9‐3 genes was performed. Seven polymorphisms rs1801131, rs1801133 (MTHFR), rs2228611 (DNMT1), rs7590760, rs1550117 (DNMT3A), rs6087990, rs2424913 (DNMT3B) were genotyped and an analysis of association with global DNA methylation was performed. The global methylation levels were lower in cancer patients recovered from OM than in the other groups. A higher frequency of unmethylated profile for miR‐9‐1 and partially methylated profile for miR‐9‐3 was observed in cancer patients regardless of OM history compared to healthy patients. The GG genotype of the rs2228611 (DNMT1) polymorphism was associated with higher levels of global methylation in cancer patients irrespective of OM. It was concluded that global methylation is associated with mucosal recovery. The effect of DNMT1 genotype on the global DNA methylation profile, as well as the methylation profile of miR‐9‐1 and miR‐9‐3 in cancer patients is independent of OM.
Unveiling the value of C‐reactive protein as a severity biomarker and the IL4/IL13 pathway as a therapeutic target in recessive dystrophic epidermolysis bullosa: A multiparametric cross‐sectional study
Authors: Quintana‐Castanedo Lucía , Sánchez‐Ramón Silvia , Maseda Rocío , Illera Nuria , Pérez‐Conde Isabel , Molero‐Luis Marta , Butta Nora , Arias‐Salgado Elena G. , Monzón‐Manzano Elena , Zuluaga Pilar , Martínez‐Santamaría Lucía , Fernández‐Arquero Miguel , Llames Sara G. , Meana Álvaro , de Lucas Raúl , del Río Marcela , Vicente Ángeles , Escámez María José , Sacedón Rosa 
Published: July 2024

AbstractPatients with recessive dystrophic epidermolysis bullosa (RDEB) experience numerous complications, which are exacerbated by inflammatory dysregulation and infection. Understanding the immunological mechanisms is crucial for selecting medications that balance inflammation control and immunocompetence. In this cross‐sectional study, aiming to identify potential immunotherapeutic targets and inflammatory biomarkers, we delved into the interrelationship between clinical severity and systemic inflammatory parameters in a representative RDEB cohort. Encompassing 84 patients aged 1–67 and spanning all three Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) severity categories, we analysed the interrelationship of infection history, standard inflammatory markers, systemic cytokines and Ig levels to elucidate their roles in RDEB pathophysiology. Our findings identify C‐reactive protein as an excellent biomarker for disease severity in RDEB. A type 2 inflammatory profile prevails among moderate and severe RDEB patients, correlating with dysregulated circulating IgA and IgG. These results underscore the IL4/IL13 pathways as potential evidence‐based therapeutic targets. Moreover, the complete inflammatory scenario aligns with Staphylococcus aureus virulence mechanisms. Concurrently, abnormalities in IgG, IgE and IgM levels suggest an immunodeficiency state in a substantial number of the cohort's patients. Our results provide new insights into the interplay of infection and immunological factors in the pathogenesis of RDEB.
Did the entry of the corn ethanol industry in Brazil affect the relationship between domestic and international corn prices?
Authors: Justus Marcelo , Bachion Luciane Chiodi , Arantes Sofia Marques , Moreira Marcelo Melo Ramalho , Rodrigues Luciano 
Published: July 2024

AbstractThis study investigates the relationship between corn prices in Brazil and the international market, considering a rise in corn ethanol production in Brazil's Midwest region since 2017. Did the entry of the corn ethanol industry in Brazil affect the relationship between domestic and international corn prices? A cointegration analysis was made with a monthly time series from May 2005 to August 2023 controlling for different exogenous events or shocks that may have affected global agricultural markets. The study's findings indicate a stable long‐term relationship between the international and Brazilian corn prices, with changes in international prices being predictors of variations in Brazilian domestic prices, while the opposite was not statistically supported. The study also found no evidence to support the claim that the entry of the corn ethanol industry into Mato Grosso state in 2017 impacted the prices paid to local producers. Therefore, the increase in Brazilian corn prices cannot be attributed to additional demand for corn by local mills, an important result that contributes to discussions such as food versus fuel and indirect land use change.
Misrecognition and labor market inclusion of refugee mothers
Authors: Maj Jolanta , Hamza‐Orlinska Aneta , Sytnik Inessa , Stopochkin Artem , Özbilgin Mustafa 
Published: July 2024

Abstract185,000 refugees from Ukraine have started working in Poland since the Russian war began. Drawing on Bourdieusian concepts of capitals, misrecognition, habitus, and the field, the paper theorizes the subjective and objective terms of inclusion across intersectional interplay of motherhood, ethnicity, and refugee status. In particular, we explore how intersectional marginalized identities of individuals shape their negotiation power over terms of their labor market inclusion. Using qualitative interview data from 10 Ukrainian working mothers in Poland who became refugees following the Russian war in Ukraine in 2022, we demonstrate that misrecognition leads to uneven relations of power curtailing working refugee mothers' agency to negotiate the terms of their inclusion.
Retained PAX2 expression associated with DNA mismatch repair deficiency in endometrial endometrioid adenocarcinoma
Authors: X. Zhang Gloria , Yang Bin 
Published: July 2024

AimsLoss of expression of tumour suppressor PAX2 and MMR deficiency (dMMR) has been frequently seen in endometrial endometrioid adenocarcinoma (EEC). However, the relationship between PAX2 expression and MMR status is unknown.Methods and ResultsWe studied the PAX2 expression and examined its association with MMR status at the protein and genetic levels in 180 cases of EEC. Overall, total loss of PAX2 expression was found in about 70%, while retained PAX2 expression was seen in 30% of EEC. Among 125 cases with loss of PAX2, 68.8% were found in EECs with pMMR, while 31.2% were seen in those with dMMR. Among 55 cases of EECs with retained PAX2 expression, 92.7% were EECs with dMMR and 7.3% were those with pMMR (P < 0.001). While dMMR cases with MLH1 hypermethylation show almost equal retained or loss of PAX2 expression (52% versus 48%), dMMR with genetic alterations had significantly more retained PAX2 expression than loss of PAX2 (92.3% versus 7.7%), regardless of somatic or germline mutations. Loss of PAX2 was observed in 97.3% of dMMR with MLH1 hypermethylation compared to 2.7% of dMMR with genetic alterations (P < 0.001). Aggressive features such as higher tumour grades (FIGO 2–3) and advanced clinical stage (T2–T4) were significantly more frequently seen in dMMR with retained PAX2 expression, compared those to pMMR with loss of PAX2 expression.ConclusionOur study demonstrates a close correlation between retained PAX2 expression and dMMR in EEC. The molecular mechanism and clinical significance linking these two pathways in EEC remains to be unravelled.
Artificial intelligence in endodontics: Data preparation, clinical applications, ethical considerations, limitations, and future directions
Authors: Mohammad‐Rahimi Hossein , Sohrabniya Fatemeh , Ourang Seyed AmirHossein , Dianat Omid , Aminoshariae Anita , Nagendrababu Venkateshbabu , Dummer Paul Michael Howell , Duncan Henry F. , Nosrat Ali 
Published: July 2024

AbstractArtificial intelligence (AI) is emerging as a transformative technology in healthcare, including endodontics. A gap in knowledge exists in understanding AI's applications and limitations among endodontic experts. This comprehensive review aims to (A) elaborate on technical and ethical aspects of using data to implement AI models in endodontics; (B) elaborate on evaluation metrics; (C) review the current applications of AI in endodontics; and (D) review the limitations and barriers to real‐world implementation of AI in the field of endodontics and its future potentials/directions. The article shows that AI techniques have been applied in endodontics for critical tasks such as detection of radiolucent lesions, analysis of root canal morphology, prediction of treatment outcome and post‐operative pain and more. Deep learning models like convolutional neural networks demonstrate high accuracy in these applications. However, challenges remain regarding model interpretability, generalizability, and adoption into clinical practice. When thoughtfully implemented, AI has great potential to aid with diagnostics, treatment planning, clinical interventions, and education in the field of endodontics. However, concerted efforts are still needed to address limitations and to facilitate integration into clinical workflows.
Effect of silicon carbide content on microstructure, physical and mechanical properties in vat photopolymerization of alumina
Authors: Zhao Zhengyu , Wu Hailong , Guo Anfu , Kong Dekun , Wang Lu , Liu Chang , Yin Lvfa , Xia Guojun , Su Xiaofei 
Published: July 2024

AbstractVat photopolymerization (VPP) printing of ceramic parts offers advantages such as low cost, simple operation, and short fabrication cycles. However, drawbacks include low toughness and brittleness in the printed parts. This study explores enhancing the toughness and strength of alumina (Al2O3) ceramics by incorporating silicon carbide (SiC) particles as additives. The impact of varying SiC contents on the quality of VPP‐printed Al2O3 parts is examined, encompassing microstructure, physical properties, and mechanical properties. Results indicate that optimal SiC addition reduces Al2O3 ceramics' porosity, enhances crystalline quality, and boosts mechanical properties. Excessive SiC, however, diminishes these benefits. The most significant strengthening of Al2O3 parts occurred with a 1.5 wt.% SiC content, increasing bending strength and fracture toughness by 239.7% and 564.7%, respectively. This underscore SiC's positive role in enhancing the quality of VPP‐printed Al2O3 parts.
Antioxidant capacity, antitumor activity and metabolomic profile of tamarillo (Solanum betaceum)
Authors: Silva Luciana de Oliveira , Rosado Carolyne Pimentel , Samary Manuela , Cruz Marta Angela de Almeida Sousa , Montenegro Júlia , Silva Giovana Ramalho Patrizi da , Antonio Ananda da Silva , Pereira Henrique Marcelo Gualberto , Veiga‐Junior Valdir Florêncio da , Palumbo Antonio , Teodoro Anderson Junger , Nunes Juliana Cortes 
Published: July 2024

SummaryTamarillo (Solanum betaceum), native to the Andes and a PANC in Brazil, contains bioactive compounds with potential anticancer properties in vitro. This study aimed to assess the influence of tamarillo extracts for their antioxidant activity, chemical composition and antiproliferative effects on human prostate cells. Aqueous (AE) and ethanolic extracts (EE) were tested, revealing higher phenolic content and superior antioxidant activity in EE (TPC: 1191.78 ± 28.16 mg GAE/100 g, DPPH: 514.90 μmol TE g−1; FRAP: 150.35 ± 4.42 μmol Fe2SO4 g−1). UPLC‐MS analysis identified twenty‐two compound classes, mainly flavonoids (eleven), carboxylic acids and derivatives (eight), organooxygen compounds (eight) and fatty acyls (seven). Tamarillo extracts significantly reduced cell viability in DU‐145 and PC‐3 cells by almost 60% in 48 h, with PC‐3 cells showing greater resilience and a 30% reduction with EE. Additionally, tamarillo extracts induced cell cycle arrest (G2/M phase) and apoptosis, suggesting their potential as natural antioxidants with protective effects against prostate cancer.
Effectiveness of an atraumatic orogastric tube insertion protocol for the combined use of swaddling, facilitated tucking, breast milk and sucrose
Authors: Apaydin Cirik Vildan , Turkmen Ayse Sonay , Derin Esra , Yilmaz Nezahat 
Published: July 2024

AbstractAimThe study aims to develop a protocol for the combined use of swaddling, facilitated tucking, expressed breast milk and sucrose administration methods in the orogastric tube (OGT) insertion procedure and evaluate its effectiveness.MethodsThe randomized controlled trial was conducted in the Neonatal Intensive Care Unit between 15 February 2022 and 15 September 2022, with 175 preterms. Preterms at 32–34 gestational weeks were randomly allocated to five groups: routine care, swaddling + expressed breast milk, swaddling + sucrose, facilitated tucking + expressed breast milk and facilitated tucking + sucrose groups. The data were collected using the Preterm Descriptive Information Form, the Physiological Measurement Form, the COMFORTneo scale and the Premature Infant Pain Profile (PIPP).ResultsThe facilitated tucking + expressed breast milk method was found to be more effective than the routine care (pdistress < 0.001; ppain = 0.031) and swaddling + expressed breast milk (pdistress = 0.004; ppain = 0.015) methods in reducing the estimated distress and PIPP pain level of preterms during the procedure. Two minutes after the procedure, the facilitated tucking + expressed breast milk method was more effective than the routine care (p < 0.001), swaddling + expressed breast milk (p = 0.011) and swaddling + sucrose (p = 0.002) methods in reducing the comfort level score.ConclusionsThe facilitated tucking + expressed breast milk method is effective in reducing pain and distress and providing comfort during the OGT procedure.Clinical Trials ID: NCT05180058.
Migrant children and inequality in twenty‐first‐century Spain: The risk of living with no working adults in times of crisis
Authors: Muñoz‐Comet Jacobo , Arcarons Albert F. 
Published: July 2024

AbstractThis article analyses the impact of the crises on the level of inequality between native and migrant origin children in twenty‐first‐century Spain. We use microdata from the Spanish Labour Force Survey (2000–2022) to study the risk for migrant and native children of living in a household with no working adults. We hypothesize that the assimilation of the immigrant population—after more than two decades in the country—might have contributed to reducing the impact of the COVID‐19 crisis. Results show that the 2008 crisis substantially increased the gap between migrant and native children, while the impact of the pandemic has been milder. Moreover, social origin has a stronger protective effect for native children compared with children with a migrant background, especially during periods of economic downturn. However, we find that among children of low social origin, migrant children are less likely to live in a household with no working adults.
ANZTCT practice statement: sinusoidal obstruction syndrome/veno‐occlusive disease diagnosis and management
Authors: Fleming Shaun , Scott Ashleigh P. , Coutsouvelis John , Fraser Chris , Bajel Ashish , Nelson Adam , Conyers Rachel , McEwan Ashley , Yeung David , Campion Victoria , Teague Lochie , McGuire Matthew , Morris Edward , Gabriel Melissa , Wayte Rebecca , Douglas Genevieve , Chien Nicole , Hamad Nada 
Published: July 2024

AbstractSinusoidal obstruction syndrome/veno‐occlusive disease (SOS/VOD) is a life‐threatening complication which can develop after haemopoietic stem cell transplantation (HSCT) and some antibody–drug conjugates. Several SOS/VOD diagnostic and management guidelines exist, with the most recent and refined being the European Society for Blood and Marrow Transplantation adult and paediatric guidelines. Timely diagnosis and effective management (including the availability of therapeutic options) significantly contribute to improved patient outcomes. In Australia and New Zealand, there is variability in clinical practice and access to SOS/VOD therapies. This review aims to summarise the current evidence for SOS/VOD diagnosis, prevention and treatment and to provide recommendations for SOS/VOD in the context of contemporary Australasian HSCT clinical practice.
Associating factors of cognitive frailty among older people with chronic heart failure: Based on LASSO‐logistic regression
Authors: Gou Dengqun , Min Changhang , Peng Xiaofeng , Wu Hemei , Zhang Lu , Chen Yu , Tao Ming 
Published: July 2024

AbstractAimTo analyse factors associated with cognitive frailty among older chronic heart failure patients in China.DesignA cross‐sectional design.MethodsBetween August 2021 and November 2022, a total of 421 chronic heart failure patients (age ≥60 years) were randomly selected from the cardiology department of the affiliated hospital of Zunyi Medical University. The FRAIL scale, Mini‐Mental State Examination, 15‐item Geriatric Depression Scale, Social Support Rating Scale, Short‐form Mini Nutritional Assessment and Pittsburgh Sleep Quality Index were utilized for measurement and evaluation. The demographic and clinical characteristics of patients were collected. To select initial variables, the Least Absolute Shrinkage Selection Operator was applied, and then logistic regression analysis was used to confirm associating factors.ResultsAmong 421 elderly people with chronic heart failure, 83 cases (19.7%) showed cognitive frailty. Of 31 variables, seven were selected by Least Absolute Shrinkage Selection Operator regression. Finally, multivariate logistic regression revealed that the age, monthly salary, drinking, NYHA classification, length of hospital stay, depression and malnutrition risk/malnutrition were independently associated with cognitive frailty.ConclusionThe high proportion of cognitive frailty in older people with chronic heart failure should be concerned. Additionally, in the setting of cognitive frailty, efforts to diagnose it and develop interventions to prevent or reverse cognitive frailty status among older chronic heart failure patients are necessary.ImpactThe findings of our study highlight the necessity to evaluate cognitive frailty in older people with chronic heart failure and provide a new perspective and scientific basis for medical staff to develop individualized and specific interventions to prevent or reverse cognitive frailty status.Reporting MethodThis study has been reported in compliance with STROBE reporting guidelines for cross‐sectional studies.Patient or Public ContributionNo Patient or Public Contribution.