bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of long-term GH replacement therapy on cardiovascular outcomes in GH-deficient patients previously treated for acromegaly: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults
Authors: van Bunderen Christa C , van Varsseveld Nadège C , Heymans Martijn W , Franken Anton A M , Koppeschaar Hans P F , van der Lely Aart J , Drent Madeleine L 
Published: September 2014

ObjectiveThe effect of GH deficiency (GHD) on the metabolic profile of acromegaly patients is unclear in patients previously treated for acromegaly, as are the efficacy and safety of GH treatment in this particular group. The aim of the study is to describe the characteristics of patients with severe GHD who were previously treated for acromegaly, and to investigate the effects of long-term GH treatment on cardiovascular risk factors and morbidity, compared with patients who were treated for a nonfunctioning pituitary adenoma (NFPA).DesignA nationwide surveillance study.MethodsSixty-five patients from the Dutch National Registry of Growth Hormone Treatment in Adults with previous acromegaly were compared with 778 patients with previous NFPA. Cardiovascular indices, including body composition, lipid profile, glucose metabolism, blood pressure, and morbidity were investigated.ResultsGHD patients with previous acromegaly had an unfavorable metabolic profile comparable with or more than GHD patients with previous NFPA. GH treatment led to improvement of the lipid profile in both groups, also after excluding patients using lipid-lowering medication. In patients with previous acromegaly, HbA1c levels increased more than in patients with previous NFPA (estimate 0.03, 95% CI 0.002–0.06, P=0.04). The risk for developing cardiovascular diseases was not different between the groups.ConclusionsThe patients with GHD after previous acromegaly have an unfavorable metabolic profile comparable with patients with GHD after previous NFPA. In both groups, the lipid profile improves during GH treatment. Changes in glucose metabolism should be monitored closely. GH treatment in patients with GHD previously treated for acromegaly had no deleterious effect on cardiovascular morbidity.
Early water intake restriction to prevent inappropriate antidiuretic hormone secretion following transsphenoidal surgery: low BMI predicts postoperative SIADH
Authors: Matsuyama Junko , Ikeda Hidetoshi , Sato Shunsuke , Yamamoto Koh , Ohashi Genichiro , Watanabe Kazuo 
Published: September 2014

ObjectiveThe goals of this study were to assess the incidence of and risk factors for the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in patients following transsphenoidal surgery (TSS), and to validate the effectiveness of early prophylactic restriction of water intake.DesignRetrospective analysis was performed for 207 patients who had undergone TSS, including 156 patients not placed on early prophylactic water restriction. Sixty-four patients received treatment for SIADH.MethodsWe compared the incidence of SIADH between patients with and without early water intake restriction, and analyzed various risk factors for SIADH using statistical analyses.ResultsBMI was significantly lower for patients with SIADH than for those patients without SIADH. Statistical analysis revealed that the threshold BMI predicting SIADH was 26. Serum sodium levels on postoperative days 5–10 and daily urine volumes on postoperative days 5–10 were significantly lower in patients with SIADH than in those without SIADH. Postoperative body weight loss on days 6, 8, 10, and 11 was significantly higher in patients with SIADH. The incidence of SIADH after starting prophylactic water intake restriction (14%) was significantly lower than the rate before early water restriction (38%; P<0.05).ConclusionsSIADH is relatively common after TSS, and serum sodium concentrations and daily urine volumes should be carefully monitored. Patients with low preoperative BMI should be closely observed, as this represented a significant preoperative risk factor for SIADH. Early prophylactic water intake restriction appears effective at preventing postoperative SIADH.
The Genome of the Chicken DT40 Bursal Lymphoma Cell Line
Authors: Molnár János , Póti Ádám , Pipek Orsolya , Krzystanek Marcin , Kanu Nnennaya , Swanton Charles , Tusnády Gábor E , Szallasi Zoltan , Csabai István , Szüts Dávid 
Published: September 2014

Abstract
The chicken DT40 cell line is a widely used model system in the study of multiple cellular processes due to the efficiency of homologous gene targeting. The cell line was derived from a bursal lymphoma induced by avian leukosis virus infection. In this study we characterized the genome of the cell line using whole genome shotgun sequencing and single nucleotide polymorphism array hybridization. The results indicate that wild-type DT40 has a relatively normal karyotype, except for whole chromosome copy number gains, and no karyotype variability within stocks. In a comparison to two domestic chicken genomes and the Gallus gallus reference genome, we found no unique mutational processes shaping the DT40 genome except for a mild increase in insertion and deletion events, particularly deletions at tandem repeats. We mapped coding sequence mutations that are unique to the DT40 genome; mutations inactivating the PIK3R1 and ATRX genes likely contributed to the oncogenic transformation. In addition to a known avian leukosis virus integration in the MYC gene, we detected further integration sites that are likely to de-regulate gene expression. The new findings support the hypothesis that DT40 is a typical transformed cell line with a relatively intact genome; therefore, it is well-suited to the role of a model system for DNA repair and related processes. The sequence data generated by this study, including a searchable de novo genome assembly and annotated lists of mutated genes, will support future research using this cell line.
El trabajo de creación: una creación que trabaja. Teorías implícitas elaboradas por creadores artísticos
Authors: Amit Rojas Jeanette 
Published: September 2014

A partir de las reflexiones de diversos autores en torno al fenómeno de la creación, y tomando como eje central once entrevistas con artistas costarricenses, analizadas como teorías implícitas sobre su quehacer, se construye y propone una comprensión del trabajo de creación, comprensión que refleja su carácter paradójico y transicional. Se enfatiza en esta propuesta: la trama relacional que sostiene el hacer creador, el trabajo como continuidad reflexiva dentro de un ciclo de mutaciones tanto del sujeto creador como del objeto causa del trabajo, y la potencialidad creadora que subyace a todo quehacer humano además del artístico.
Referentes conceptuales y metodológicos sobre la noción moderna de validez de instrumentos de medición: implicaciones para el caso de personas con necesidades educativas especiales
Authors: Montero Rojas Eiliana 
Published: September 2014

Resumen. Se hace un recorrido en torno al concepto moderno de validez, enfocado en pruebas psicológicas y educativas, con el propósito de presentar una discusión actualizada y brindar herramientas conceptuales y metodológicas a los constructores y usuarios de instrumentos. En cuanto a la validez se indican las importantes contribuciones de Samuel Messick, incluyendo la noción de que se trata de un concepto unitario, referido al grado de propiedad de las interpretaciones e inferencias realizadas a partir de los puntajes del instrumento. Se mencionan los modelos de medición más utilizados, la Teoría Clásica de los Tests (TCT) y Teoría de Respuesta a los ítems (TRI), incluyendo los modelos de Rasch. Se introducen las temáticas de DIF (funcionamiento diferencial de los ítems) y equiparación de puntajes (equating). Finalmente, se analizan implicancias de estos referentes en términos de las adecuaciones que se deben realizar al aplicar los instrumentos a personas con necesidades educativas especiales.
Expresiones de afecto de madres bilingües
Authors: Shiro Martha 
Published: September 2014

Resumen. En la interacción de 10 madres bilingües con sus hijos de 30 meses se analiza la expresión de afectividad en L1 y en L2. Se identifi caron las expresiones de emoción, volición y actitud epistémica en 30 interacciones espontáneas: (a) 10 madres (español L1) hablando en L1, (b) 10 madres (español L1) hablando en inglés L2 y (c) 10 madres (inglés L1) hablando en L1. Los resultados sugieren que los usos de L2 difi eren de los de L1 (inglés o español): la expresión de volición y actitud epistémica se asemeja al inglés L1, mientras que la expresión de las emociones se acerca al español L1. Estos hallazgos permiten explicar los usos del lenguaje expresivo de los bilingües y ayudan a determinar sus efectos en el desarrollo del lenguaje.
Comprensión de narraciones orales en niños con Trastorno Específico del Lenguaje
Authors: Coloma Carmen Julia , Maggiolo Mariangela , Pavez María Mercedes 
Published: September 2014

El propósito del trabajo es aportar información sobre la comprensión de narraciones orales de un grupo de niños chilenos con TEL sin problemas pragmáticos. Participaron 60 niños distribuidos en tres grupos: 20 niños con TEL con una edad promedio de 6,6 años, 20 niños pareados por edad cronológica y 20 niños equiparados por edad lingüística. Ambos grupos controles presentaban desarrollo típico de lenguaje. Se evalúa la comprensión narrativa con preguntas literales e inferenciales a partir de tres cuentos. Los resultados muestran que los niños con TEL se asemejan a sus controles lingüísticos al considerar la comprensión global de la narración y también la de preguntas literales e inferenciales, diferenciándose signifi cativamente de los controles cronológicos.
Fun and frustrations: Low-income Chilean parents reminiscing with their children about past emotional experiences
Authors: Nolivos Virginia , Leyva Diana 
Published: September 2014

Una manera en que los padres de familia apoyan el desarrollo de las habilidades socioemocionales de sus niños/as es a través de narrativas (reminiscencia) sobre experiencias emocionales. Este estudio: a) investigó cómo las familias Chilenas de bajos recursos económicos identifi can, explican y razonan acerca de experiencias emocionales positivas y negativas; b) documentó los temas narrativos que se discutieron. Sesenta y dos padres de familia y sus niños/as fueron grabados en video mientras recordaban una vez cuando el niño/a estaba feliz y una vez cuando no estaba feliz. La mitad eran niñas. Las narrativas fueron transcritas y codifi cadas usando varias categorías sobre contenido emocional. Los resultados muestran que las conversaciones negativas son más ricas en contenido emocional que las conversaciones positivas. Las diadas discutieron más frecuentemente temas sobre eventos familiares cuando recordaron experiencias positivas y conflictos con pares cuando recordaron experiencias negativas. Este trabajo puede informar intervenciones con familias en Latinoamérica.
Bethe-Schwinger Effective Range Theory and Lehmann and Weinberg Chiral Perturbation Theories
Authors: Truong Tran Nguyen 
Published: September 2014

This paper is a brief review of low energy soft hadronic physics,starting from the invention of the low energy effective rangetheory in the late 40's due to Bethe and Schwinger fornucleon-nucleon scattering, and its generalization to the static Chew-Low model for pion nucleonscattering, to the present development of the Lehmann and WeinbergChiral Perturbation Theories. It is pointed out that a consistentlow energy calculation can be achieved with the incorporation ofthe unitarity relation in the Chiral Perturbation Theory.
Measurement of the Yield Ratio of the \(^{122m,g}\text{Sb}\) Isomeric Pair Above the Giant Resonance
Authors: Khue Pham Duc , Thanh Kim Tien , Do Nguyen Van 
Published: September 2014

The yield ratio of the high-spin state of \(^{122m}\text{Sb} (8^{ - })\) and the low-spin state of \(^{122g}\text{Sb} (2^{-})\) formed via the \(^{123}\text{Sb}(\gamma, n)^{122m,g}\text{Sb}\) reaction has been measured as a function of the bremsstrahlung end-point energy in the range of 40-MeV to 60-MeV. Use was made of the activation technique in combination with high-resolution \(\gamma\)-ray spectrometry. The isomeric yield ratios for the \(^{123}\text{Sb}(\gamma,n)^{122m,g}\text{Sb}\) reaction measured at 40-, 45-, 50-, 55-, and 60-MeV bremsstrahlung are \(0.341\pm 0.022\), \(0.362 \pm 0.020\), \(0.374 \pm 0.021\), \(0.371 \pm 0.021\), and \( 0.367 \pm 0.022\). According to our knowledge, the present results are the first measurement.
Order Theory of Alloy \(\beta - \text{CuZn}\)
Authors: Tam Pham Dinh , Tan Pham Duy , Hoc Nguyen Quang 
Published: September 2014

By applying the model of pair interaction, the model of central atom, the method of coordination sphere and the statistical moment method, we calculate the free energy of β- CuZn ordered alloy and determine the dependence of ordered parameter and lattice constant on pressure and temperature for this alloy. The obtained results have simple analytic, easy to calculate form and our numerical results are in good agreement with the experimental data.
Chiral Anomaly, Triangle Loop and the \(\gamma\gamma^{*}\to \pi^{0}\) Transition Form Factor
Authors: Nang Pham Tri , Yem Pham Xuan 
Published: September 2014

The recent BaBar measurements of the \(\gamma +\gamma ^{ * } \to \pi ^{0 }\) form factor show spectacular deviation from perturbative QCD computations for large space-like \(Q^{2}\). At 34 GeV\(^{2}\) the data are more than 50% larger than theoretical predictions. Stimulated by these new experimental results, we revisit our previous paper on triangle loop effects related to chiral anomaly, and apply our method to the \(\gamma +\gamma ^{ * } \to \pi ^{0 }\) transition form factor measured in the single tag mode \(e^{ + }+e^{ - } \to e^{ + }+ e^{ - }+\pi ^{0 }\) with one highly virtual photon \(\gamma ^{ * }\). The resultant form factor \(F(Q^{2})\)- which depends on only one parameter (the mass \(m\) of up, down quark circulating in the triangle loop) behaves like \((m^{2}/Q^{2}) \times [\ln (Q^{2}/m^{2})]^{2}\)- shows a striking agreement with BaBar data for \(m \approx 132\) MeV. The rising logarithm squared form factor, surprisingly unnoticed in the literature, is in sharp contrast with the rather flat ones derived from perturbative QCD approaches.
Influence of the Frequency-chirp Gaussian Pulse on the Pulse Broadening in the Dispersive Fibers
Authors: Kien Bui Xuan , Hung Tran Hai , Chien Trinh Dinh 
Published: September 2014

A signal optical pulse propagating in the fiber is affected by many factors, one of the most important among them is dispersion. Under the dispersive influence, the optical pulse is reshaped, particulally, its duration is changed. Especially, the pulse duration change of the optical short pulse with the frequency-chirp is unregular. It influences to the propagating distance in the fiber optic network. In this paper, the expression of the signal optical pulse with the frequency-chirp propagated through the dispersive fiber is derived. This expression described the broadening of the pulse in propagating process (broadening factor), which depends on the frequence chirp and dispersive parameters. The influence of those parameters on the pulse broadening is simulated and discussed.
Structural and Optical Properties of Samples SrTi\(_{1-x}\)M\(_{x}\)O\(_3\) (M = Co, Ni) Synthesized by Sol-gel Method
Authors: Phuong Doan Thi Thuy , Minh Nguyen Van , Dung Chu Tien 
Published: September 2014

By sol-gel method, we synthesized SrTi\(_{1-x}\)M\(_{x}\)O\(_3\) (M = Co, Ni; x = 0.0; 0.1; 0.2; 0.3; 0.4; 0.5) nano particles and investigated structure of Raman spectrum, absorption spectra, structural diagram of energy area and their density of states. The results showed that the average size of nanoparticles was about 10-30 nm. Absorption edge of each sample depended on the content of substitution of Co, Ni. Besides, the content of ion substitution also had influence on the structure, Raman spectrum, structural diagram of energy area and state density of samples. The results indicated that Co and Ni ions were substituted for position of Ti in the net cell, which changed structure of the material and reduced band gap of the synthesized materials and increases its conductivity.
Descriptions of Immature Stages of Three Species of Laccocorinae (Hemiptera: Heteroptera: Naucoridae) from India
Authors: Sundar S , Sites Robert W , Arunachalam M 
Published: September 2014

AbstractAdults and first through fifth instars of three species of Naucoridae in the subfamily Laccocorinae were collected from localities in Tamil Nadu and Karnataka states in southern India. Specifically, Heleocoris indicus (Montandon) and Heleocoris vicinus (Montandon) were collected from the vegetated margins of streams that contained no congeners. Pogonocaudina indica Sites & Zettel was collected from vertical rock surfaces at the type locality. All instars of these three species are described here. First instars of both species of Heleocoris are immaculate, whereas subsequent instars are densely punctate. The first instar of P. indica has pronounced dorsal tubercles with stout spines, whereas subsequent instars lack these structures. All instars of P. indica have a deep terminal cleft and dense fringe of hairs on the perimeter of the posterior abdominal segments. Second through fifth instars of these three species can be distinguished based on relative length of the mesonotal wing pad compared with the exposed part of the metanotal lateral margin.
Prevention of Anterior Cruciate Ligament Rupture in Female Athletes
Authors: Ramirez Rey N. , Baldwin Keith , Franklin Corinna C.D. 
Published: September 2014

Background:
A number of reports have been published on the effectiveness and design of intervention programs for the prevention of rupture of the anterior cruciate ligament (ACL) in female athletes. The purpose of this study was to systematically review the literature to determine the effectiveness of neuromuscular training programs in preventing ACL injury in female athletes.

Methods:
A systematic review was performed with use of the PubMed, MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases. The search terms included “anterior cruciate ligament” and “ACL” combined with “prevention” and “intervention.” The searches included material indexed by September 30, 2013. Data concerning study design, the characteristics of participants, the details of the neuromuscular programs, the types of sports, and number of ACL ruptures were extracted from the studies. Study heterogeneity was assessed with funnel plot and Egger regression methods. Pooled effects were calculated with use of a DerSimonian-Laird random-effects model. The number needed to treat was calculated on the basis of pooled incidence data.

Results:
The risk of ACL rupture was 1.83 times higher for female athletes who did not participate in neuromuscular ACL-prevention training programs (odds ratio [OR], 1.83; 95% confidence interval [95% CI], 1.08 to 3.10; p = 0.02). In studies that focused exclusively on soccer, the risk of ACL rupture was 2.62 times higher for nonparticipating athletes (OR, 2.62; 95% CI, 1.59 to 4.32; p < 0.01). When the data were analyzed according to the timing of the intervention, no significant effects were found. In studies in which the program took place both preseason and in-season, the risk (odds ratio) of ACL rupture for nonparticipating athletes was 2.34 (95% CI, 0.82 to 6.7; p = 0.11). In studies in which the intervention took place in-season only, the risk (odds ratio) of ACL rupture for nonparticipating athletes was 1.25 (95% CI, 0.23 to 6.75; p = 0.8). The number needed to treat to prevent a single ACL rupture was 128.7 athletes. We found no significant heterogeneity among the included studies. The I2 value was 35.40% (p = 0.11). No significant publication bias was found in our included studies.

Conclusions:
The results of this systematic review and meta-analysis favor a protective effect of neuromuscular training programs on the risk of ACL rupture in female athletes. This protective effect is more pronounced in soccer players. Additional research is needed to design the optimal training program.

Level of Evidence:
Therapeutic Level II. See Instructions to Authors for a complete description of levels of evidence.
Clinical features of progressive vacuolar hepatopathy in Scottish Terriers with and without hepatocellular carcinoma: 114 cases (1980–2013)
Authors: Cortright Catherine C. , Center Sharon A. , Randolph John F. , McDonough Sean P. , Fecteau Kellie A. , Warner Karen L. , Chiapella Ann M. , Pierce Rhonda L. , Graham A. Heather , Wall Linda J. , Heidgerd John H. , Degen Melisa A. , Lucia Patricia A. , Erb Hollis N. 
Published: September 2014

Abstract
Objective—To characterize signalment, clinical features, clinicopathologic variables, hepatic ultrasonographic characteristics, endocrinologic profiles, treatment response, and age at death of Scottish Terriers with progressive vacuolar hepatopathy (VH) with or without hepatocellular carcinoma (HCC).
Design—Retrospective case series.
Animals—114 Scottish Terriers with progressive VH.
Procedures—Electronic databases from 1980 to 2013 were searched for adult (age > 1 year) Scottish Terriers with histopathologic diagnoses of diffuse glycogen-like VH. Available sections of liver specimens were histologically reevaluated to confirm diffuse VH with or without HCC; 8 dogs with HCC only had neoplastic tissue available. Physical examination, clinicopathologic, treatment, and survival data were obtained.
Results—39 of 114 (34%) dogs with VH had HCC detected at surgery or necropsy or by abdominal ultrasonography. Histologic findings indicated that HCC was seemingly preceded by dysplastic hepatocellular foci. No significant differences were found in clinicopathologic variables or age at death between VH-affected dogs with or without HCC. Fifteen of 26 (58%) dogs with high hepatic copper concentrations had histologic features consistent with copper-associated hepatopathy. Although signs consistent with hyperadrenocorticism were observed in 40% (46/114) of dogs, definitive diagnosis was inconsistently confirmed. Assessment of adrenal sex hormone concentrations before and after ACTH administration identified high progesterone and androstenedione concentrations in 88% (22/25) and 80% (20/25) of tested dogs, respectively.
Conclusions and Clinical Relevance—Results suggested that VH in Scottish Terriers may be linked to adrenal steroidogenesis and a predisposition to HCC. In dogs with VH, frequent serum biochemical analysis and ultrasonographic surveillance for early tumor detection are recommended.
The Parrot UAV Controlled by PID Controllers
Authors: Koszewnik Andrzej 
Published: September 2014

Abstract
The paper presents the process of modeling and designing control laws for four-rotor type of the Parrot UAV. The state space model is obtained by using several phenomena like gyroscopic effects for rigid bodies, propellers and rotors. The obtained model has been used to design PID control laws for roll, pitch, yaw angle and altitude, respectively. The numerical simulations of the closed loop model are shown that system in satisfy way stabilize flight of the quadro-rotor in all considered directions.