bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paths of energy in turbulent channel flows
Authors: Cimarelli A. , De Angelis E. , Casciola C. M. 
Published: January 2013

AbstractThe paper describes the energy fluxes simultaneously occurring in the space of scales and in the physical space of wall-turbulent flows. The unexpected behaviour of the energy fluxes consists of spiral-like paths in the combined physical/scale space where the controversial reverse energy cascade plays a central role. Two dynamical processes are identified as driving mechanisms for the fluxes, one in the near-wall region and a second one further away from the wall. The former, stronger, one is related to the dynamics involved in the near-wall turbulence regeneration cycle. The second suggests an outer self-sustaining mechanism which is asymptotically expected to take place in the eventual log layer and could explain the debated mixed inner/outer scaling of the near-wall statistics. The observed behaviour may have strong repercussions on both theoretical and modelling approaches to wall turbulence, as anticipated by a simple equation which is shown able to capture most of the rich dynamics of the shear-dominated region of the flow.
Fluid–structure interaction-induced oscillation of flexible structures in laminar and turbulent flows
Authors: Gomes Jorge Pereira , Lienhart H. 
Published: January 2013

AbstractSelf-excitation of the motion of a structure has become a prominent aspect of engineering projects over recent years as designers are using materials at their limits, causing structures to become progressively lighter, more flexible and, therefore, prone to vibrate. Stimulated by the increasing interest in fluid–structure interaction (FSI) problems, this study investigated the instability and consequent FSI-induced self-excited oscillation of flexible structures in uniform flows at Reynolds numbers between$10$and$1. 69\times 1{0}^{5} $. The investigations were performed in both water and a highly viscous syrup ($\nu = 1. 64\times 1{0}^{- 4} ~{\mathrm{m} }^{2} ~{\mathrm{s} }^{- 1} $) and considered three structures of different geometries. The results were conclusive in showing that the motion of the structure was characterized by a sequence of oscillation modes as a function of the characteristics of the structure and flow properties. In addition, it was possible to identify the self-excitation mechanisms as being of the instability-induced excitation (IIE) or movement-induced excitation (MIE) types. IIE was observed to be the most dominant mechanism of excitation at lower velocities and it was defined by a direct relation between the flow fluctuation and natural frequencies of the structure. For that reason, IIE was strongly determined by the geometry of the front body of the structure. At higher velocities, the amplitudes of the flow disturbances generated by the structure movement increased and excitations of the MIE type became predominant for all structures. The MIE mechanism was found to be weakly influenced by the shape of the structure but very sensitive to its dynamic characteristics and to the properties of the fluid, especially the Reynolds number.
Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study
Authors: Strain J. J. , McSorley Emeir M. , van Wijngaarden Edwin , Kobrosly Roni W. , Bonham Maxine P. , Mulhern Maria S. , McAfee Alison J. , Davidson Philip W. , Shamlaye Conrad F. , Henderson Juliette , Watson Gene E. , Thurston Sally W. , Wallace Julie M. W. , Ueland Per M. , Myers Gary J. 
Published: January 2013

Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system. Animal studies have shown that choline status pre- and postnatally can have long-lasting effects on attention and memory; however, effects in human subjects have not been well studied. The aim of the present study was to examine the association between plasma concentrations of free choline and its related metabolites in children and their neurodevelopment in the Seychelles Child Development Nutrition Study, an ongoing longitudinal study assessing the development of children born to mothers with high fish consumption during pregnancy. Plasma concentrations of free choline, betaine, dimethylglycine (DMG), methionine and homocysteine and specific measures of neurodevelopment were measured in 210 children aged 5 years. The children's plasma free choline concentration (9·17 (sd2·09) μmol/l) was moderately, but significantly, correlated with betaine (r0·24;P= 0·0006), DMG (r0·15;P= 0·03), methionine (r0·24;P= 0·0005) and homocysteine (r0·19;P= 0·006) concentrations. Adjusted multiple linear regression revealed that betaine concentrations were positively associated with Preschool Language Scale – total language scores (β = 0·066;P= 0·04), but no other associations were evident. We found no indication that free choline concentration or its metabolites, within the normal physiological range, are associated with neurodevelopmental outcomes in children at 5 years of age. As there is considerable animal evidence suggesting that choline status during development is associated with cognitive outcome, the issue deserves further study in other cohorts.
Identification of stably expressed QTL for heading date using reciprocal introgression line and recombinant inbred line populations in rice
Authors: CHENG LI-RUI , WANG JUN-MIN , YE GUOYOU , LUO CHENG-GANG , XU JIAN-LONG , LI ZHI-KANG 
Published: January 2013

SummaryTwo sets of reciprocal introgression lines (ILs) and a population of recombinant inbred lines (RILs) derived from the cross betweenjaponicacultivar Xiushui09 andindicabreeding line IR2061-520-6-9 (abbreviated as IR2061) were used to identify QTL for heading date (HD). Phenotyping was conducted in Hainan Island for two winter seasons (2007 and 2009). Nine QTLs were detected in the ILs with Xiushui09 background (XS-ILs), and four of which were repeatedly mapped across 2 years. Five QTLs were identified in the ILs with IR2061 background (IR-ILs), and three of which were commonly detected in 2 years. All commonly detected QTL had the same direction of gene effect. Seven QTL for HD were identified in the RILs in 2009. Only three (25%) QTLs were commonly detected using all the three populations (XS-ILs, IR-ILs and RILs). The number of commonly identified QTLs among populations was related to degree of similarity of their genetic backgrounds, suggesting that the genetic background effect is important for detecting HD QTL.QHd7andQHd10bstably expressed in different populations and across years thus would be exploited in rice breeding programme. Moreover, lines with both ofQHd7andQHd10bresulted in at least 3 days earlier than lines with only one of them QTL, showing evident pyramiding effect.
Racialism on the Left E.D. Morel and the “Black Horror on the Rhine”
Authors: Reinders Robert C. 
Published: January 2013

On April 6, 1920 the French government, in reprisal for the entry of German troops into the demilitarized zone of the Ruhr, occupied Frankfurt, Darmstadt, Hanau, and Homburg. During the occupation French Moroccan soldiers fired on a German mob in Frankfurt and killed several. In covering the event the Daily Herald, alone among English newspapers, called special attention to the “race” of the French troops. It headlined:FRANKFURT RUNS WITH BLOODFRENCH BLACK TROOPS USEMACHINE GUNS ON CIVILIANSOn April 10, the Herald followed its accounts of events on the Rhine by a front page article by Edmund Dene Morel under banner leads:BLACK SCOURGE IN EUROPESEXUAL HORROR LET LOOSE BY FRANCE ON RHINE DISAPPEARANCE OF YOUNG GERMAN GIRLSFrance, Morel wrote, “is thrusting her black savages …into the heart of Germany.” There “primitive African barbarians”, carriers of syphilis, have become a “terror and a horror” to the Palatinate countryside. The “barely restrainable beastiality of the black troops” has led to many rapes, an especially serious problem since Africans are “the most developed sexually of any” race and “for well-known physiological reasons, the raping of a white woman by a negro is nearly always accompanied by serious injury and not infrequently has fatal results.…” Morel had reports of rapes, “some of them of an atrocious character”, and of “dead bodies of young women discovered under manure heaps and so on”. German municipalities were forced to provide bordellos and white women, and even young boys, for these over-sexed blacks. Master-minding this effort to “ruin, enslave, degrade, dismember [and] reduce to the lowest depths of despair and humiliation a whole people” was a “ruthless” and militaristic French government. Furthermore Morel warned his working class readers, “If the manhood of these races, not so advanced in the forms of civilisation as ourselves, are to be used against the Germans, why not against the workers here or elsewhere?”
THE SOCIOECONOMIC DYNAMICS OF THESHIFTACONFLICT IN KENYA,c. 1963–8
Authors: WHITTAKER HANNAH ALICE 
Published: January 2013

ABSTRACTUsing a set of oral testimonies, together with military, intelligence, and administrative reports from the 1960s, this article re-examines theshiftaconflict in Kenya. The article moves away from mono-causal, nationalistic interpretations of the event, to focus instead on the underlying socioeconomic dynamics and domestic implications of the conflict. It argues that the nationalist interpretation fails to capture the diversity of participation inshifta, which was not simply made up of militant Somali nationalists, and that it fails to acknowledge the significance of an internal Kenyan conflict between a newly independent state in the process of nation building, and a group of ‘dissident’ frontier communities that were seen to defy the new order. Examination of this conflict provides insights into the operation of the early postcolonial Kenyan state.
HUNTING REPUTATIONS: TALENT, INDIVIDUALS, AND COMMUNITY IN PRECOLONIAL SOUTH CENTRAL AFRICA
Authors: DE LUNA KATHRYN M. 
Published: January 2013

ABSTRACTThe familiar mystique of African hunters was not a foregone conclusion to the practitioners, dependents, and leaders who created it. Late in the first millennium, Botatwe farmers’ successful adoption of cereals and limited cattle sustained the transformation of hunting from a generalist's labor into a path to distinction. Throughout the second millennium, the basis of hunters’ renown diversified as trade intensified, new political traditions emerged, and, eventually, the caravan trade andmfecaneravaged established communities. The story of Botatwe hunters reveals alongue duréehistory of local notables and the durability of affective, social dimensions of recognition in the face of changes in the material, political, and technological basis sustaining such status.
Different heritabilities but shared etiological influences for parent, teacher and self-ratings of ADHD symptoms: an adolescent twin study
Authors: Merwood A. , Greven C. U. , Price T. S. , Rijsdijk F. , Kuntsi J. , McLoughlin G. , Larsson H. , Asherson P. J. 
Published: January 2013

BackgroundParent and teacher ratings of attention deficit hyperactivity disorder (ADHD) symptoms yield high estimates of heritability whereas self-ratings typically yield lower estimates. To understand why, the present study examined the etiological overlap between parent, teacher and self-ratings of ADHD symptoms in a population-based sample of 11–12-year-old twins.MethodParticipants were from the Twins Early Development Study (TEDS). ADHD symptoms were assessed using the Strengths and Difficulties Questionnaire (SDQ) hyperactivity scale completed by parents, teachers and children. Structural equation modeling was used to examine genetic and environmental contributions to phenotypic variance/covariance.ResultsThe broad-sense heritability of ADHD symptoms was 82% for parent ratings, 60% for teacher ratings and 48% for self-ratings. Post-hoc analyses revealed significantly higher heritability for same-teacher than different-teacher ratings of ADHD (76% v. 49%). A common pathway model best explained the relationship between different informant ratings, with common genetic influences accounting for 84% of the covariance between parent, teacher and self-rated ADHD symptoms. The remaining variance was explained by rater-specific genetic and non-shared environmental influences.ConclusionsDespite different heritabilities, there were shared genetic influences for parent, teacher and self-ratings of ADHD symptoms, indicating that different informants rated some of the same aspects of behavior. The low heritability estimated for self-ratings and different-teacher ratings may reflect increased measurement error when different informants rate each twin from a pair, and/or greater non-shared environmental influences. Future studies into the genetic influences on ADHD should incorporate informant data in addition to self-ratings to capture a pervasive, heritable component of ADHD symptomatology.
New estimates for the heat flux across the Polar Front: spatial and temporal variability in recent years
Authors: De Souza João Marcos Azevedo Correia , De Moraes Paiva Afonso , Von Schuckmann Karina 
Published: January 2013

AbstractTwo different methodologies are applied in order to quantify the eddy contribution to the heat flux across the Polar Front, between January 2006 and December 2009. First, the eddy fluxes are indirectly estimated through a heat balance based on geostrophic fluxes obtained from the Argo climatological temperature and salinity. Second, a parametric model based on sea level anomaly data from a merged satellite product is used to obtain a direct estimate of the eddy heat flux and its temporal and spatial variability. The results obtained through the heat balance (-80.5 ± 16.45 x 1013 W) and the parameterization (-56.2 ± 4.18 x 1013 W) are within the range established by previous studies. The eddy heat flux is observed to be concentrated in a few narrow regions, with a particularly large contribution from the Atlantic sector. A trend of intensification of the southward heat flux is observed in the study period (-0.44 x 1013 W year-1), compatible with recent modelling and observational studies.
Procedural Learning in Specific Language Impairment: Effects of Sequence Complexity
Authors: Gabriel Audrey , Maillart Christelle , Stefaniak Nicolas , Lejeune Caroline , Desmottes Lise , Meulemans Thierry 
Published: January 2013

AbstractAccording to the procedural deficit hypothesis (PDH), abnormal development in the procedural memory system could account for the language deficits observed in specific language impairment (SLI). Recent studies have supported this hypothesis by using a serial reaction time (SRT) task, during which a slower learning rate is observed in children with SLI compared to controls. Recently, we obtained contrasting results, demonstrating that children with SLI were able to learn a sequence as quickly and as accurately as controls. These discrepancies could be related to differences in the statistical structure of the SRT sequence between these studies. The aim of this study was to further assess, in a group of 21 children with SLI, the PDH with second-order conditional sequences, which are more difficult to learn than those used in previous studies. Our results show that children with SLI had impaired procedural memory, as evidenced by both longer reaction times and no sign of sequence-specific learning in comparison with typically developing controls. These results are consistent with the PDH proposed by Ullman and Pierpont (2005) and suggest that procedural sequence-learning in SLI children depends on the complexity of the to-be-learned sequence. (JINS, 2013, 19, 1–8)
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
Authors: Campos Alline C. , Ortega Zaira , Palazuelos Javier , Fogaça Manoela V. , Aguiar Daniele C. , Díaz-Alonso Javier , Ortega-Gutiérrez Silvia , Vázquez-Villa Henar , Moreira Fabricio A. , Guzmán Manuel , Galve-Roperh Ismael , Guimarães Francisco S. 
Published: January 2013

AbstractCannabidiol (CBD), the main non-psychotomimetic component of the plant Cannabis sativa, exerts therapeutically promising effects on human mental health such as inhibition of psychosis, anxiety and depression. However, the mechanistic bases of CBD action are unclear. Here we investigate the potential involvement of hippocampal neurogenesis in the anxiolytic effect of CBD in mice subjected to 14 d chronic unpredictable stress (CUS). Repeated administration of CBD (30 mg/kg i.p., 2 h after each daily stressor) increased hippocampal progenitor proliferation and neurogenesis in wild-type mice. Ganciclovir administration to GFAP-thymidine kinase (GFAP-TK) transgenic mice, which express thymidine kinase in adult neural progenitor cells, abrogated CBD-induced hippocampal neurogenesis. CBD administration prevented the anxiogenic effect of CUS in wild type but not in GFAP-TK mice as evidenced in the novelty suppressed feeding test and the elevated plus maze. This anxiolytic effect of CBD involved the participation of the CB1 cannabinoid receptor, as CBD administration increased hippocampal anandamide levels and administration of the CB1–selective antagonist AM251 prevented CBD actions. Studies conducted with hippocampal progenitor cells in culture showed that CBD promotes progenitor proliferation and cell cycle progression and mimics the proliferative effect of CB1 and CB2 cannabinoid receptor activation. Moreover, antagonists of these two receptors or endocannabinoid depletion by fatty acid amide hydrolase overexpression prevented CBD-induced cell proliferation. These findings support that the anxiolytic effect of chronic CBD administration in stressed mice depends on its proneurogenic action in the adult hippocampus by facilitating endocannabinoid-mediated signalling.
From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II—Sensitivity to Physiological and Physicochemical Properties
Authors: Krekels EHJ , Johnson TN , den Hoedt SM , Rostami‐Hodjegan A , Danhof M , Tibboel D , Knibbe CAJ 
Published: January 2013

To develop a maturation function for drug glucuronidation in children, that can be used in population and physiologically based modeling approaches, the physiological and physicochemical basis of a semiphysiological glucuronidation function for children was untangled using Simcyp. The results show that using the currently available in vitro data, in vivo morphine and zidovudine clearances were under predicted by the physiologically based model in Simcyp. The maturation profile was similar to the clinically observed profile except for the first 2 weeks of life, and liver size and UGT2B7 ontogeny are the physiological drivers of the maturation of glucuronidation. Physicochemical drug parameters did not affect this maturation profile, although log P and pKa influenced the absolute value of clearance. The results suggest that the semiphysiological glucuronidation function for young children can be used to predict the developmental clearance profile of other UGT2B7 substrates, though scenarios with nonlinear kinetics and high‐extraction ratios require further investigation.CPT: Pharmacometrics & Systems Pharmacology (2012) 1, e10; doi:10.1038/psp.2012.12; advance online publication 10 October 2012
Mitochondrial (dys)function and regulation of macrophage cholesterol efflux
Authors: Allen Anne Marie , Taylor Janice M. W. , Graham Annette 
Published: January 2013

Cholesterol trafficking from the outer to the cholesterol-poor inner mitochondrial membrane requires energized, polarized and actively respiring mitochondria, mediated by a highly regulated multimeric (140–200 kDa) protein complex comprising StAR (steroidogenic acute regulatory protein), mitochondrial TSPO (translocator protein), VDAC (voltage-dependent anion channel), ANT (adenine nucleotide transporter) and associated regulatory proteins. Mitochondrial cholesterol transport is rate-limiting in the CYP27A1 (sterol 27-hydroxylase)-dependent generation of oxysterol ligands for LXR (liver X receptor) transcription factors that regulate the expression of genes encoding proteins in the cholesterol efflux pathway, such as ABC transporters (ATP-binding cassette transporters) ABCA1 and ABCG1. These transporters transfer cholesterol and/or phospholipids across the plasma membrane to (apo)lipoprotein acceptors, generating nascent HDLs (high-density lipoproteins), which can safely transport excess cholesterol through the bloodstream to the liver for excretion in bile. Utilizing information from steroidogenic tissues, we propose that perturbations in mitochondrial function may reduce the efficiency of the cholesterol efflux pathway, favouring accumulation of cholesteryl ester ‘foam cells’ and allowing the toxic accumulation of free cholesterol at the interface between the endoplasmic reticulum and the mitochondrial membrane. In turn, this will trigger opening of the permeability transition pore, allowing unregulated production of oxysterols via CYP27A1, allowing the accumulation of esterified forms of this oxysterol within human atherosclerotic lesions. Defective cholesterol efflux also induces endoplasmic reticulum stress, proteasomal degradation of ABCA1 and Fas-dependent apoptosis, replicating findings in macrophages in advanced atherosclerotic lesions. Small molecules targeted to mitochondria, capable of sustaining mitochondrial function or improving cholesterol trafficking may aid cholesterol efflux from macrophage ‘foam’ cells, regressing and stabilizing the atherosclerotic plaque.
Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation
Authors: Bijland Silvia , Mancini Sarah J. , Salt Ian P. 
Published: January 2013

AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while stimulating catabolic ATP-generating pathways. This has led to considerable interest in AMPK as a therapeutic target for the metabolic dysfunction observed in obesity and insulin resistance. The role of AMPK in skeletal muscle and the liver has been extensively studied, such that AMPK has been demonstrated to inhibit synthesis of fatty acids, cholesterol and isoprenoids, hepatic gluconeogenesis and translation while increasing fatty acid oxidation, muscle glucose transport, mitochondrial biogenesis and caloric intake. The role of AMPK in the other principal metabolic and insulin-sensitive tissue, adipose, remains poorly characterized in comparison, yet increasing evidence supports an important role for AMPK in adipose tissue function. Obesity is characterized by hypertrophy of adipocytes and the development of a chronic sub-clinical pro-inflammatory environment in adipose tissue, leading to increased infiltration of immune cells. This combination of dysfunctional hypertrophic adipocytes and a pro-inflammatory environment contributes to insulin resistance and the development of Type 2 diabetes. Exciting recent studies indicate that AMPK may not only influence metabolism in adipocytes, but also act to suppress this pro-inflammatory environment, such that targeting AMPK in adipose tissue may be desirable to normalize adipose dysfunction and inflammation. In the present review, we discuss the role of AMPK in adipose tissue, focussing on the regulation of carbohydrate and lipid metabolism, adipogenesis and pro-inflammatory pathways in physiological and pathophysiological conditions.