bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualization of air flow around soccer ball using a particle image velocimetry
Authors: Hong Sungchan , Asai Takeshi , Seo Kazuya 
Published: October 2015

AbstractA traditional soccer ball is constructed using 32 pentagonal and hexagonal panels. In recent years, however, the likes of the Teamgeist and Jabulani balls, constructed from 14 and 8 panels, respectively, have entered the field, marking a significant departure from conventionality in terms of shape and design. Moreover, the recently introduced Brazuca ball features a new 6-panel design and has already been adopted by many soccer leagues. However, the shapes of the constituent panels of these balls differ substantially from those of conventional balls. Therefore, this study set out to investigate the flight and aerodynamic characteristics of different orientations of the soccer ball, which is constructed from panels of different shapes. A wind tunnel test showed substantial differences in the aerodynamic forces acting on the ball, depending on its orientation. Substantial differences were also observed in the aerodynamic forces acting on the ball in different directions, corresponding to its orientation and rotation. Moreover, two-dimensional particle image velocimetry (2D-PIV) measurements showed that the boundary separation varies depending on the orientation of the ball. Based on these results, we can conclude that the shape of the panels of a soccer ball substantially affects its flight trajectory.
The role of miR-19b in the inhibition of endothelial cell apoptosis and its relationship with coronary artery disease
Authors: Tang Yong , Zhang Ya-chen , Chen Yu , Xiang Yin , Shen Cheng-xing , Li Yi-gang 
Published: October 2015

AbstractThe biological effects of microRNAs (miRNAs) and TNF-α in atherosclerosis have been widely studied. The circulating miR-17-92 cluster has been recently shown to be significantly downregulated in patients with injured vascular endothelium. However, it remains unclear whether the miR-17-92 cluster plays a significant role in vascular endothelial repair. The aim of this study was to investigate the relationship between the miR-17-92 cluster and TNF-α-induced endothelial cell apoptosis. We determined that the down-regulation of miR-19b level among patients with coronary artery disease was consistent with miRNA expression changes in endothelial cells following 24 h of TNF-α treatment. In vitro, the overexpression of miR-19b significantly alleviated the endothelial cells apoptosis, whereas the inhibition of miR-19b significantly enhanced apoptosis. The increased levels of Afap1 and caspase7 observed in our apoptosis model could be reduced by miR-19b and this effect could be due to miR-19b binding 3′-UTRs of Afap1 and caspase7 mRNA. Therefore our results indicate that miR-19b plays a key role in the attenuation of TNF-α-induced endothelial cell apoptosis and that this function is closely linked to the Apaf1/caspase-dependent pathway.
Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia
Authors: Ingason A , Giegling I , Hartmann A M , Genius J , Konte B , Friedl M ,   Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC), Ripke S , Sullivan P F , St. Clair D , Collier D A , O'Donovan M C , Mirnics K , Rujescu D 
Published: October 2015

AbstractAntagonists of the N-methyl-D-aspartate (NMDA)-type glutamate receptor induce psychosis in healthy individuals and exacerbate schizophrenia symptoms in patients. In this study we have produced an animal model of NMDA receptor hypofunction by chronically treating rats with low doses of the NMDA receptor antagonist MK-801. Subsequently, we performed an expression study and identified 20 genes showing altered expression in the brain of these rats compared with untreated animals. We then explored whether the human orthologs of these genes are associated with schizophrenia in the largest schizophrenia genome-wide association study published to date, and found evidence for association for 4 out of the 20 genes: SF3B1, FOXP1, DLG2 and VGLL4. Interestingly, three of these genes, FOXP1, SF3B1 and DLG2, have previously been implicated in neurodevelopmental disorders.
Brain structure, cognition and negative symptoms in schizophrenia are associated with serum levels of polysialic acid-modified NCAM
Authors: Piras F , Schiff M , Chiapponi C , Bossù P , Mühlenhoff M , Caltagirone C , Gerardy-Schahn R , Hildebrandt H , Spalletta G 
Published: October 2015

AbstractThe neural cell adhesion molecule (NCAM) is a glycoprotein implicated in cell–cell adhesion, neurite outgrowth and synaptic plasticity. Polysialic acid (polySia) is mainly attached to NCAM (polySia-NCAM) and has an essential role in regulating NCAM-dependent developmental processes that require plasticity, that is, cell migration, axon guidance and synapse formation. Post-mortem and genetic evidence suggests that dysregulation of polySia-NCAM is involved in schizophrenia (SZ). We enrolled 45 patients diagnosed with SZ and 45 healthy individuals who were submitted to polySia-NCAM peripheral quantification, cognitive and psychopathological assessment and structural neuroimaging (brain volumes and diffusion tensor imaging). PolySia-NCAM serum levels were increased in SZ patients, independently of antipsychotic treatment, and were associated with negative symptoms, blunted affect and declarative memory impairment. The increased polySia-NCAM levels were associated with decreased volume in the left prefrontal cortex, namely Brodmann area 46, in patients and increased volume in the same brain area of healthy individuals. As this brain region is involved in the pathophysiology of SZ and its associated phenomenology, the data indicate that polySia-NCAM deserves further scrutiny because of its possible role in early neurodevelopmental mechanisms of the disorder.
Extraction of small‐signal model parameters of Si/SiGe heterojunction bipolar transistor using least squares support vector machines
Authors: Taher H. , Farrell R. , Schreurs D. , Nauwelaers B. 
Published: October 2015

A novel straightforward methodology for extracting bias‐dependent small‐signal equivalent circuit model parameters (SSECMPs) of silicon/silicon–germanium heterojunction bipolar transistors is presented. The inverse mapping between SSECMPs and scattering (S) parameters is established and fitted using simulated data of the SSECM. Since the problem has large input space, S‐parameters at many frequency points, the least squares support vector machines concept is used as regression technique. Physical SSECMPs values are obtained using the proposed methodology. Moreover, an excellent agreement is noted between the S‐parameters measurements and their simulated counterpart using the extracted SSECMPs in the frequency range from 40 MHz to 40 GHz at different bias conditions.
Experimental study of 80 GHz Fabry‐Pérot cavity antenna based on dual‐layer partially reflected surface
Authors: FanHong M. , Ouslimani H.H , Gueye M.B. , Letestu Y. 
Published: October 2015

A Fabry‐Pérot cavity antenna based on a dual‐layer partially reflected surface (PRS) structure is designed, fabricated and measured at 80 GHz (band‐E). The PRS is composed of two frequency selective surfaces, each comprising a periodic array of square metallic patches. When excited by a single primary source, the antenna's gain and directivity increase by ∼10 dB from 81 to 86 GHz. The dimensions of the prototype compact antenna are 100 × 100 × 4 mm3.
Clinical Study of Extrapulmonary Head and Neck Tuberculosis: A Single-Institute 10-year Experience
Authors: Oishi Masahiro , Okamoto Sachimi , Teranishi Yuichi , Yokota Chieko , Takano Sakurako , Iguchi Hiroyoshi 
Published: October 2015

Introduction Although the incidence of tuberculosis (TB) in Japan has been decreasing yearly, Japan remains ranked as an intermediate-burden country for TB.
Objective This study aims to investigate the current situation of head and neck extrapulmonary TB (EPTB) diagnosed in our department.
Methods We retrospectively reviewed the clinical records of 47 patients diagnosed with EPTB in the head and neck in our department between January 2005 and December 2014. The extracted data included sex and age distribution, development site, chief complaint, presence or absence of concomitant active pulmonary TB (PTB) or history of TB, tuberculin skin test (TST) results, interferon-gamma release assay (IGRA) results, and duration from the first visit to the final diagnosis of EPTB.
Results The subjects consisted of 20 men and 27 women, and age ranged from 6 to 84 years. The most common site was the cervical lymph nodes (30 patients), with the supraclavicular nodes being the most commonly affected (60%). Histopathological examination was performed on 28 patients. TST was positive in 9 out of 9 patients and the IGRA was positive in 18 out of 19 patients. We observed concomitant PTB in 15 out of the 47 patients. Mean duration from the first visit to the final diagnosis of EPTB was 56 days.
Conclusion The clinical symptoms of TB, especially those in the head and neck region, are varied. Otolaryngologists should be especially aware of the extrapulmonary manifestations of TB to ensure early diagnosis and treatment from the public health viewpoint.
Measuring the impact of Ebola control measures in Sierra Leone
Authors: Kucharski Adam J. , Camacho Anton , Flasche Stefan , Glover Rebecca E. , Edmunds W. John , Funk Sebastian 
Published: October 2015

Significance
Between June 2014 and February 2015, thousands of Ebola treatment beds were introduced in Sierra Leone, alongside other infection control measures. However, there has been criticism of the timing and focus of this response, and it remains unclear how much it contributed to curbing the 2014–2015 Ebola epidemic. Using a mathematical model, we estimated how many Ebola virus disease cases the response averted in each district of Sierra Leone. We estimated that 56,600 (95% credible interval: 48,300–84,500) Ebola cases were averted in Sierra Leone as a direct result of additional treatment beds. Moreover, the number of cases averted would have been even greater had beds been available 1 month earlier.
Postcolonial Affect: Ambiguous Relationality in Robert Casteels's L’(autre) fille aux cheveux de Bali
Authors: Lee Gavin 
Published: October 2015

ABSTRACTThis article examines postcolonial affect as expressed in the Belgian-born Singaporean citizen Robert Casteels's L’(autre) fille aux cheveux de Bali (2002), in which it is shown that sonic identities (gamelan and Chinese instruments; quotations from Debussy and Bartók) give way to the ambiguous, modulating relationality of dis/affiliation, dis/affinity and a/proximity. Micro-changes in musical affect lead to the loosening of enculturated or acculturated emotional and perceptual responses associated with established identities. Musical affect thus serves as a corrective to neatly differentiated identities that are constructed in narratives of imperial exoticism, postcolonial autonomy or multicultural harmony.
Morphogenetic and phenological changes in phenolic content of Hypericum leptophyllum, an endemic Turkish species
Authors: Seyis Fatih , Radusiene Jolita , Ivanauskas Liudas , Jakstas Valdas , Cirak Cuneyt 
Published: October 2015

The present study was conducted to determine the morphogenetic and phenologic variations in the content of the main bioactive compounds in Hypericum leptophyllum Hochst., an endemic species from Turkish flora. Wild plants were harvested at five phenological stages: vegetative, floral budding, full flowering, fresh fruiting, and mature fruiting, and assayed for chemical content by HPLC. Results indicated that H. leptophyllum did not accumulate hypericin, pseudohypericin, hyperforin, and adhyperforin. The phenolic content in whole plants increased generally during plant phenology and higher accumulation levels were observed at flowering. Among the reproductive organs, amentoflavone, quercetin, avicularin, and hyperoside contents were the highest in floral buds (2.09, 2.18, 0.55, and 2.62 mg g−1 dry mass (DM), respectively). Leaves harvested at the floral budding stage produced the highest content of chlorogenic acid, neochlorogenic acid, caffeic acid, and isoquercetin (53.32, 6.25, 0.03, and 1.91 mg g−1 DM, respectively), while leaves of plants at the vegetative stage of plant development accumulated the highest content of 2,4-dihydroxybenzoic acid and quercitrin (0.29 and 0.54 mg g–1 DM, respectively). This is the first report of the presence of avicularin, rutin, (+)-catechin, (–)-epicatechin, amentoflavone, caffeic acid, neochlorogenic acid, and 2,4-dihydroxybenzoic acid in this species. Such data could be useful for the evaluation of new sources of bioactive compounds, as well as for increasing phytotaxonomic knowledge for the poorly studied Hypericum species.
Plato’s Hermaphrodite and a Vindication of the Sense of Touch in the Sixteenth Century
Authors: Maurette Pablo 
Published: October 2015

AbstractThis essay considers readings of Plato’sSymposiumin sixteenth-centurytrattati d’amore(love treatises) — especially Francesco Patrizi’sL’amorosa filosofia— that offer an alternative to Marsilio Ficino’s pervasive interpretation as presented in hisDe amore. Against the backdrop of a larger debate concerning the role of the lower senses (touch, in particular) and the relationship between body and soul, these alternative readings of theSymposiumattempt to redeem the role of tactility in love matters. Whereas Ficino and his most influential followers — Pico della Mirandola, Pietro Bembo, and Baldassare Castiglione — center their exegesis on Diotima’s speech and privilege sight as the most noble sense, Patrizi’s reading — to a large extent preceded by those of Sperone Speroni, Agnolo Firenzuola, and Flaminio Nobili — focuses on Aristophanes’s myth and the figure of the hermaphrodite as the model for a different kind of human love that is both sensual and spiritual.
A multi-objective optimization approach accurately resolves protein domain architectures
Authors: Bernardes J.S. , Vieira F.R.J. , Zaverucha G. , Carbone A. 
Published: October 2015

Abstract
Motivation: Given a protein sequence and a number of potential domains matching it, what are the domain content and the most likely domain architecture for the sequence? This problem is of fundamental importance in protein annotation, constituting one of the main steps of all predictive annotation strategies. On the other hand, when potential domains are several and in conflict because of overlapping domain boundaries, finding a solution for the problem might become difficult. An accurate prediction of the domain architecture of a multi-domain protein provides important information for function prediction, comparative genomics and molecular evolution.
Results: We developed DAMA (Domain Annotation by a Multi-objective Approach), a novel approach that identifies architectures through a multi-objective optimization algorithm combining scores of domain matches, previously observed multi-domain co-occurrence and domain overlapping. DAMA has been validated on a known benchmark dataset based on CATH structural domain assignments and on the set of Plasmodium falciparum proteins. When compared with existing tools on both datasets, it outperforms all of them.
Availability and implementation: DAMA software is implemented in C++ and the source code can be found at http://www.lcqb.upmc.fr/DAMA.
Contact: juliana.silva_bernardes@upmc.fr or alessandra.carbone@lip6.fr
Supplementary information: Supplementary data are available at Bioinformatics online.
Prototheca wickerhamii in a Patient With Chronic Hepatitis C
Authors: Cooper Joseph David , Tyler William , Hoyos Carlos Mario Jaramillo , Medina Rowena Atienza 
Published: October 2015

Abstract
Protothecosis is an infection caused by members of the genus Prototheca. The organisms are achlorophyllic algae that are present in different environmental niches and are globally distributed. It is a rare cause of infection in humans with majority of reported cases occurring in immunocompromised individuals. More than half of the cases manifest as cutaneous lesions. Diagnosis is by microbiological culture and/or histopathology. Response to treatment, mostly with antifungal agents, is variable. We present a 66-year-old man with type 2 diabetes mellitus, severe chronic obstructive pulmonary disease on intermittent corticosteroids, and untreated chronic hepatitis C who had a nonresolving rash. This consisted of generalized pruritic, scaly and erythematous papules, and plaques for 15 years. Subsequent skin biopsy and microbiological isolation revealed Prototheca wickerhamii. To the best of our knowledge, this is the second known case of cutaneous Prototheca infection in a patient with chronic hepatitis C.
Family Italian listed firms
Authors: Culasso Francesca , Giacosa Elisa , Broccardo Laura , Manzi Luca Maria 
Published: October 2015

Purpose– The purpose of this study is to underscore the impact of the family variable on performance. The authors were interested in understanding whether the differences between Family Firms (FFs) and Non-Family Firms (NFFs), on the one hand, and between large FFs and medium-sized FFs, on the other, were reflected in the performance achieved.Design/methodology/approach– In this paper a sample of 80 industrial companies listed on the Italian Stock Market (FTSE MIB and STAR indexes) were considered, and mixed criteria to distinguish FFs and NFFs (Smyrnios-Romanoet al., 1998) were used. The empirical method allowed the development of some research hypotheses by exploiting the Pearson correlation.Findings– There are two main categories of FFs, which correspond to two different strategic and organizational categories, namely, the FFs listed on the large capitalized companies index (FTSE MIB) and the FFs listed on the medium-capitalized companies index (STAR). Each kind of FFs (large FFs and medium-sized FFs) has a specific effect on profitability and financial performance. Specifically, if a company is medium sized, family presence is a relevant variable in achieving better profitability and financial performance than NFFs of the same size; on the other hand, if the company expands to become a large one, the family presence is an irrelevant variable in terms of both profitability and financial leverage (debt ratio).Research limitations/implications– Limitations of the study concern the definition of the sample, as this paper focused on the industrial sector and the method adopted, as it could be integrated with some econometrical models. The implications of this paper are relevant for families and regulatory bodies because it helps them better understand the effects of governance and company size both on short- and long-term performance. Moreover, the findings of the study can influence the decision-making process of investors to identify the long-term outperformers listed on the Italian Stock Exchange.Originality/value– This study contributes to the literature on FFs by defining two different categories of FFs, namely, large and medium-sized. It seems that larger companies record a weaker family influence on short-term profitability.
Leader culpability, hopelessness, and learning during organizational crises
Authors: Kovoor-Misra Sarah , Olk Paul 
Published: October 2015

Purpose– The purpose of this paper is to investigate followers’ judgments of leader culpability and learning during a crisis, and the extent to which judgments of culpability create hopelessness and reduce crisis learning. The authors also study factors that moderate these relationships.Design/methodology/approach– Using the survey method the authors collected data from 354 individuals from a nonprofit organization that filed for bankruptcy. Respondents’ comments also provided qualitative data that was used to triangulate the findings.Findings– The authors find that followers made judgments of leader culpability and reported crisis learning. However, followers’ judgments have no direct effect on their crisis learning, but have an indirect effect by increasing hopelessness. The authors also find that followers’ job satisfaction and perceptions of sufficient crisis communications moderate this relationship. The qualitative data provides insights into the areas on which leaders were judged, and what was learned during the crisis.Research limitations/implications– More research on internal stakeholders’ judgments of their leaders during organizational crises is important as they affect followers’ psychological states and behaviors. Future research can test the findings in a longitudinal study.Practical implications– Leaders need to pay attention to the judgments of their followers during a crisis as they could foster hopelessness and reduce learning. Providing sufficient crisis communications and enabling job satisfaction could lessen these negative effects.Originality/value– Extant research tends to focus on the judgments of external stakeholders during crises. This study is one of the first to examine the effects of internal stakeholders’ judgments of leader culpability on their sense of hopelessness and crisis learning, and the moderating factors that reduce their negative effects. The authors also contribute to understanding what aspects of leadership are judged by followers during a crisis, and what followers learn from a crisis. These are areas that have not been previously examined in crisis management research. The authors also provide evidence from individuals in an actual organization in crisis which tends not to be the norm in crisis attribution and crisis learning research.
Assessment of climatic risks for real estate
Authors: Hirsch Jens , Braun Thomas , Bienert Sven 
Published: October 2015

Purpose
– The purpose of this paper is to investigate the functionality and main results of the ImmoRisk tool. The aim of the project of the Federal Ministry for Transport, Building and Urban Development (BMVBS), in corporation with the Federal Institute for Research on Building, Urban Affairs and Spatial Development (BBSR), was to develop a user-friendly tool that provides a sound basis with respect to the risk situation caused by extreme weather events.

Design/methodology/approach
– The tool calculates the annual expected losses (AEL) for different types of extreme weather hazard and the damage rate as the proportion of AEL on building value, based on a trinomial approach: natural hazard, vulnerability and the value of the property.

Findings
– The paper provides property-specific risk profiles of both the present and future risk situation caused by various extreme weather events.

Research limitations/implications
– The approach described in the paper can serve as a model for the realization of subsequent tools in further countries bound with other climatic risks.

Practical implications
– The real estate industry is affected by a significant rise in monetary damages caused by extreme weather events. Accordingly, the approach is suitable for implementation in the companies’ real estate risk management systems.

Social implications
– The tool offers homeowners a profound basis for investment decisions with regard to adaptation measures.

Originality/value
– The approach pioneers fourfold: first, by meeting the needs of the housing and real estate industry based on a trinomial approach; second, by using a property-specific bottom-up approach; third, by offering both a comprehensive risk assessment of the hazards storms, flood and hailstorm and finally, by providing results with respect to the future climatic risk situation.