bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective analysis of the quality of reports by author-suggested and non-author-suggested reviewers in journals operating on open or single-blind peer review models
Authors: Kowalczuk Maria K , Dudbridge Frank , Nanda Shreeya , Harriman Stephanie L , Patel Jigisha , Moylan Elizabeth C 
Published: October 2015

ObjectivesTo assess whether reports from reviewers recommended by authors show a bias in quality and recommendation for editorial decision, compared with reviewers suggested by other parties, and whether reviewer reports for journals operating on open or single-blind peer review models differ with regard to report quality and reviewer recommendations.DesignRetrospective analysis of the quality of reviewer reports using an established Review Quality Instrument, and analysis of reviewer recommendations and author satisfaction surveys.SettingBioMed Central biology and medical journals.BMC Infectious DiseasesandBMC Microbiologyare similar in size, rejection rates, impact factors and editorial processes, but the former uses open peer review while the latter uses single-blind peer review. TheJournal of Inflammationhas operated under both peer review models.SampleTwo hundred reviewer reports submitted toBMC Infectious Diseases, 200 reviewer reports submitted toBMC Microbiologyand 400 reviewer reports submitted to theJournal of Inflammation.ResultsFor each journal, author-suggested reviewers provided reports of comparable quality to non-author-suggested reviewers, but were significantly more likely to recommend acceptance, irrespective of the peer review model (p<0.0001 forBMC Infectious Diseases, BMC Microbiologyand theJournal of Inflammation). ForBMC Infectious Diseases, the overall quality of reviewer reports measured by the Review Quality Instrument was 5% higher than forBMC Microbiology(p=0.042). For theJournal of Inflammation, the quality of reports was the same irrespective of the peer review model used.ConclusionsReviewers suggested by authors provide reports of comparable quality to non-author-suggested reviewers, but are significantly more likely to recommend acceptance. Open peer review reports forBMC Infectious Diseaseswere of higher quality than single-blind reports forBMC Microbiology.There was no difference in quality of peer review in theJournal of Inflammationunder open peer review compared with single blind.
Improving referrals to the Liaison service at the Royal United Hospital in Bath
Authors: Gomes-Pinto Alister , Kuzminskyte Ruta , Wooding Katie , Asplin Katherine , Ewins Liz 
Published: October 2015

AbstractPsychiatry liaison services provide the interface between mental and physical health in the acute medical hospital, however there can be logistical and operational difficulties to overcome.This quality improvement project aimed to improve the timeliness of referrals to a liaison service from an acute hospital through simple interventions of a newsletter, email to staff, and a pilot including attending post-take ward rounds on the Medical Assessment Unit (MAU) of the hospital. This resulted in a faster referral process to liaison as well as improved staff satisfaction with the liaison service, both of which will have a positive benefit on the clinical management of patients and the patients experience in hospital.There was a significant improvement in overall staff satisfaction with the referral pathway, appropriateness of referrals and working hours of the Mental Health Liaison Team - increasing from 14% at baseline to 100% at the end of the study. Referral outcomes also showed a considerable improvement, with the percentage of junior doctors successfully able to locate the referral form increasing from 60% at baseline to 100%.
Applying quality improvement into systems-based learning to improve diabetes outcomes in primary care
Authors: Moreo Kathleen , Sapir Tamar , Greene Laurence 
Published: October 2015

AbstractIn the U.S., where the prevalence of type 2 diabetes has reached epidemic proportions, many patients with this disease are treated by primary care physicians in community based systems, including accountable care organisations (ACOs). To address gaps in the quality of diabetes care, national quality measures have been established, including patient centered measures adopted by the Centers for Medicare and Medicaid Services for its Shared Savings Program for ACOs.From a patient centered perspective, high quality diabetes care depends on effective communication between clinicians and patients, along with patient education and counselling about medications and lifestyle. We designed and implemented a quality improvement (QI) program for 30 primary care physicians treating patients with type 2 diabetes in three structurally similar but geographically diverse ACOs. Retrospective chart audits were conducted before (n = 300) and after (n = 300) each physician participated in accredited continuing medical education (CME) courses that focused on QI strategies. Randomly selected charts were audited to measurably assess essential interventions for improved outcomes in type 2 diabetes including the physicians’ documentation of patient counselling and assessment of side effects, and patients’ medication adherence status and changes in hemoglobin A1C (A1C) and body mass index (BMI). Paced educational interventions included a private performance improvement Internet live course conducted for each physician, small group Internet live courses involving peer discussion, and a set of enduring materials, which were also multi accredited for all clinicians in the physician’s practice. Continual improvement cycles were guided by analysis of the baseline chart audits, quantitative survey data, and qualitative feedback offered by participants. To extend the benefit of the education, the enduring materials were offered to the interprofessional team of clinicians throughout the U.S. who did not participate in the QI program. For brevity, this article presents outcomes of the 30 primary care physicians.Baseline to post education improvements were observed for percentages of charts with documented assessment of medication side effects (+11%) and counselling about medication risks/benefits (+28%), medication adherence (+13%), and lifestyle modifications (+8%). Improvements were also observed for documented adherence to diabetes medications (+24%) and first-to-last-visit changes in A1C (-0.16%) and BMI (-2.1). The findings indicate a positive influence of QI education on primary care physicians’ performance of patient centered quality measures and patient outcomes.
Lifestyle factors and experience of respiratory alarm symptoms in the general population
Authors: Sele Lisa Maria Falk , Balasubramaniam Kirubakaran , Elnegaard Sandra , Søndergaard Jens , Jarbøl Dorte Ejg 
Published: October 2015

BackgroundThe first step in the diagnosis of lung cancer is for individuals in the general population to recognise respiratory alarm symptoms (RAS). Knowledge is sparse about RAS and factors associated with experiencing RAS in the general population. This study aimed to estimate the prevalence of RAS in the general population, and to analyse possible associations between lifestyle factors and experiencing RAS.MethodsA web-based survey comprising 100 000 individuals randomly selected from the Danish Civil Registration System. Items regarding experience of RAS (prolonged coughing, shortness of breath, coughing up blood and prolonged hoarseness) and self-reported lifestyle factors (smoking status, alcohol intake and body mass index) were included in the analysis.ResultsA total of 49 706 individuals completed the questionnaire. 16 per cent reported at least one RAS. Prolonged coughing (8.4%) and shortness of breath (8%) were most prevalent, while coughing up blood was least prevalent (0.1%). More men than women reported RAS (p<0.001). Odds of reporting RAS increased with age (Ptrend<0.001). In men and women, former and current smoking was associated with reporting at least one RAS (former smoking: ORmen=1.42, 95% CI 1.39 to 1.56; ORwomen=1.25, 95% CI 1.15 to 1.36; current smoking: ORmen=2.58, 95% CI 2.35 to 2.83; ORwomen=2.45, 95% CI 2.25 to 2.68). Individuals who were underweight or obese were significantly more likely to report at least one RAS. Odds of reporting at least one RAS increased with increasing alcohol intake for both genders (Ptrend<0.001).ConclusionsRAS are common in the general population. Men experience more symptoms than women, and prevalence increases with age. Being a former or current smoker and being underweight or obese are positively associated with experiencing RAS. The likelihood of experiencing RAS increases with increasing alcohol intake. Future research should investigate healthcare seeking for RAS among individuals with different lifestyles.
Synthesis and characterization of microinductor made of NiCuZn nanoferrite
Authors: Kumar Sontosh , Madhuri W. , Kalainathan S. 
Published: October 2015

The objective of mechanical stress sensor is to measure the applied pressure or provide control standard to the process. In order to accomplish this, most of the stress sensors convert mechanical stress into electronic signal. Ferrites are the best known magnetic semiconductors. This paper brings out the variation in inductance of the micro-inductor made from [Formula: see text] on application of mechanical stress. [Formula: see text] ferrite nanoparticles are synthesized by sol–gel autocombustion technique. The ferrite powder thus obtained is double sintered at 450[Formula: see text]C and 870[Formula: see text]C in a microwave furnace. The X-ray diffraction pattern of the ferrite confirms spinal structure. The frequency spectrum of dielectric constant is done in the range of 100 to 5 MHz frequency. The variation of inductance [Formula: see text]% with applied compressive stress on the micro-inductor made from the ferrite is measured in the range of 0–8 MPa.
Chinese Herbal Medicines Might Improve the Long-Term Clinical Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: Results of a Decision-Analytic Markov Model
Authors: Wang Shao-Li , Wang Cheng-Long , Wang Pei-Li , Xu Hao , Chen Ke-Ji , Shi Da-Zhuo 
Published: October 2015

Aims. The priority of Chinese herbal medicines (CHMs) plus conventional treatment over conventional treatment alone for acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) was documented in the 5C trial (chictr.org number:ChiCTR-TRC-07000021). The study was designed to evaluate the 10-year effectiveness of CHMs plus conventional treatment versus conventional treatment alone with decision-analytic model for ACS after PCI.Methods and Results. We constructed a decision-analytic Markov model to compare additional CHMs for 6 months plus conventional treatment versus conventional treatment alone for ACS patients after PCI. Sources of data came from 5C trial and published reports. Outcomes were expressed in terms of quality-adjusted life years (QALYs). Sensitivity analyses were performed to test the robustness of the model. The model predicted that over the 10-year horizon the survival probability was 77.49% in patients with CHMs plus conventional treatment versus 77.29% in patients with conventional treatment alone. In combination with conventional treatment, 6-month CHMs might be associated with a gained 0.20% survival probability and 0.111 accumulated QALYs, respectively.Conclusions. The model suggested that treatment with CHMs, as an adjunctive therapy, in combination with conventional treatment for 6 months might improve the long-term clinical outcome in ACS patients after PCI.
Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade
Authors: Iams Wade T. , Lovly Christine M. 
Published: October 2015

Abstract
The IGF1R signaling pathway is a complex and tightly regulated network that is critical for cell proliferation, growth, and survival. IGF1R is a potential therapeutic target for patients with many different malignancies. This brief review summarizes the results of clinical trials targeting the IGF1R pathway in patients with breast cancer, sarcoma, and non–small cell lung cancer (NSCLC). Therapeutic agents discussed include both monoclonal antibodies to IGF1R (dalotuzumab, figitumumab, cixutumumab, ganitumab, R1507, AVE1642) and newer IGF1R pathway targeting strategies, including monoclonal antibodies to IGF1 and IGF2 (MEDI-573 and BI 836845) and a small-molecule tyrosine kinase inhibitor of IGF1R (linsitinib). The pullback of trials in patients with breast cancer and NSCLC based on several large negative trials is noted and contrasted with the sustained success of IGF1R inhibitor monotherapy in a subset of patients with sarcoma. Several different biomarkers have been examined in these trials with varying levels of success, including tumor expression of IGF1R and its pathway components, serum IGF ligand levels, alternate pathway activation, and specific molecular signatures of IGF1R pathway dependence. However, there remains a critical need to define predictive biomarkers in order to identify patients who may benefit from IGF1R-directed therapies. Ongoing research focuses on uncovering such biomarkers and elucidating mechanisms of resistance, as this therapeutic target is currently being analyzed from the bedside to bench. Clin Cancer Res; 21(19); 4270–7. ©2015 AACR.
Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients
Authors: Kurose Koji , Ohue Yoshihiro , Wada Hisashi , Iida Shinsuke , Ishida Takashi , Kojima Takashi , Doi Toshihiko , Suzuki Susumu , Isobe Midori , Funakoshi Takeru , Kakimi Kazuhiro , Nishikawa Hiroyoshi , Udono Heiichiro , Oka Mikio , Ueda Ryuzo , Nakayama Eiichi 
Published: October 2015

Abstract
Purpose: FoxP3+ Tregs inhibit immune responses against tumors. KW-0761 is a humanized anti-human CCR4 monoclonal antibody (mAb) that has antibody-dependent cellular cytotoxicity activity. Depletion of CCR4-expressing FoxP3+ CD4 Tregs by KW-0761 infusion was investigated in solid cancer patients.
Experimental Design: We conducted a phase Ia clinical trial of KW-0761 infusion in 7 lung and 3 esophageal cancer patients. Toxicity, clinical efficacy, changes in lymphocyte subpopulations, including Tregs, and induction of immune responses were analyzed.
Results: The results showed that KW-0761 infusion in a dose range between 0.1 mg/kg and 1.0 mg/kg was safe and well tolerated. No dose-limiting toxicity was observed. Four of 10 patients showed stable disease during treatment and were long survivors. The monitoring of FoxP3+ Tregs in the peripheral blood mononuclear cells during treatment indicated efficient depletion of those cells, even at the lowest dose of 0.1 mg/kg used. The reduction in Th 1 CD4 T cells and CD8 T cells was limited, whereas a significant reduction was observed with Th 2 and Th 17 CD4 T cells. Immune responses to cancer/testis (CT) antigens and an autoantibody response to thyroid peroxidase were observed in some patients.
Conclusions: The findings showed Tregs depletion and the possible occurrence of an immune response following KW-0761 infusion. Combined use of KW-0761 to deplete FoxP3+ Tregs with other immunotherapies, such as cancer vaccines or checkpoint inhibitors, is a promising approach to augment immune responses. Clin Cancer Res; 21(19); 4327–36. ©2015 AACR.
T Regulatory Cells Gone Bad: An Oncogenic Immune Response against Enterotoxigenic B. fragilis Infection Leads to Colon Cancer
Authors: Irrazabal Thergiory , Martin Alberto 
Published: October 2015

Abstract
Summary: T regulatory cells trigger an oncogenic immune response against enterotoxigenic B. fragilis infection. The implications of an overall shift in the colonic homeostasis are discussed. Cancer Discov; 5(10); 1021–3. ©2015 AACR.
See related article by Geis and colleagues, p. 1098.
Point-of-care genetic profiling and/or platelet function testing in acute coronary syndrome
Authors: Collet Jean-Philippe , Kerneis Mathieu , Hulot Jean-Sebastien , O’Connor Stephen A. , Silvain Johanne , Mansencal Nicolas , Brugier Delphine , Abtan Jérémie , Barthélémy Olivier , Vignalou Jean-Baptiste , Payot Laurent , Rousseau Héléne , Vicaut Eric , Montalescot Gilles ,   for the GAMMA investigators
Published: October 2015

SummaryOur aim was to demonstrate that the sequential use of the Verigene® rapid CYP2C19 test for genetic profiling and the VerifyNowTM bedside test for platelet function measurement in ACS patients may optimise P2Y12 inhibition. “Rapid” (CYP2C19*1/*1 or CYP2C19*17 carriers, n=211) and “slow” metabolisers (CYP2C19*2 carriers, n=58) were first put on clopidogrel and prasugrel for ≥ 2 weeks, respectively. Patients with low platelet reactivity (PRU< 30) on prasugrel or high platelet reactivity (> 208 PRU) on clopidogrel were then switched to clopidogrel and prasugrel, respectively. Our objectives were (i) to demonstrate that the proportion of “rapid” metabolisers on 75 mg of clopidogrel within 30–208 (PRU) of P2Y12 inhibition is non-inferior to “slow” metabolisers on prasugrel 10 mg and (ii) to evaluate the same end-point after switching drugs. The proportion of “rapid” and “slow” metabolisers within 30–208 PRU of P2Y12 inhibition was 71 % and 56.9 %, respectively, an absolute difference of +14.1 % (95 % CI, –0.05 % to 28.28 %) with a non-inferiority margin greater than the predefined margin of –10 %. Among patients out of target, all but one “slow” metabolisers displayed low-on prasugrel platelet reactivity while the majority of “rapid” metabolisers (68 %) displayed high-on clopidogrel platelet reactivity. After switching, the proportion of patients within 30–208 PRU of P2Y12 inhibition was 83.6 % and 79.3 % in “rapid” and “slow” metabolisers, respectively (+4.3 %, 95 % CI –7.3 % to 15.9 %). In conclusion, this study demonstrates a loose relationship between genotype and platelet function phenotype approaches but that they are complementary to select prasugrel or clopidogrel MD in stented ACS patients.
LM-CMA: An Alternative to L-BFGS for Large-Scale Black Box Optimization
Authors: Loshchilov Ilya 
Published: October 2015

Limited-memory BFGS (L-BFGS; Liu and Nocedal, 1989 ) is often considered to be the method of choice for continuous optimization when first- or second-order information is available. However, the use of L-BFGS can be complicated in a black box scenario where gradient information is not available and therefore should be numerically estimated. The accuracy of this estimation, obtained by finite difference methods, is often problem-dependent and may lead to premature convergence of the algorithm.This article demonstrates an alternative to L-BFGS, the limited memory covariance matrix adaptation evolution strategy (LM-CMA) proposed by Loshchilov ( 2014 ). LM-CMA is a stochastic derivative-free algorithm for numerical optimization of nonlinear, nonconvex optimization problems. Inspired by L-BFGS, LM-CMA samples candidate solutions according to a covariance matrix reproduced from m direction vectors selected during the optimization process. The decomposition of the covariance matrix into Cholesky factors allows reducing the memory complexity to [Formula: see text], where n is the number of decision variables. The time complexity of sampling one candidate solution is also [Formula: see text] but scales as only about 25 scalar-vector multiplications in practice. The algorithm has an important property of invariance with respect to strictly increasing transformations of the objective function; such transformations do not compromise its ability to approach the optimum. LM-CMA outperforms the original CMA-ES and its large-scale versions on nonseparable ill-conditioned problems with a factor increasing with problem dimension. Invariance properties of the algorithm do not prevent it from demonstrating a comparable performance to L-BFGS on nontrivial large-scale smooth and nonsmooth optimization problems.
Using High-Resolution GPS Tracking Data of Bird Flight for Meteorological Observations
Authors: Treep Jelle , Bohrer Gil , Shamoun-Baranes Judy , Duriez Olivier , Prata de Moraes Frasson Renato , Bouten Willem 
Published: October 2015

AbstractBird flight is strongly influenced by local meteorological conditions. With increasing amounts of high-frequency GPS data of bird movement becoming available, as tags become cheaper and lighter, opportunities are created to obtain large datasets of quantitative meteorological information from observations conducted by bird-borne tags. In this article we propose a method for estimating wind velocity and convective velocity scale from tag-based high-frequency GPS data of soaring birds in flight.The flight patterns of soaring birds are strongly influenced by the interactions between atmospheric boundary layer processes and the morphology of the bird; climb rates depend on vertical air motion, flight altitude depends on boundary layer height, and drift off the bird’s flight path depends on wind speed and direction. We combine aerodynamic theory of soaring bird flight, the bird’s morphological properties, and three-dimensional GPS measurements at 3-s intervals to estimate the convective velocity scale and horizontal wind velocity at the locations and times of flight.We use wind speed and direction observations from meteorological ground stations and estimates of convective velocity from the Ocean–Land–Atmosphere Model (OLAM) to evaluate our findings. Although not collocated, our wind velocity estimates are consistent with ground station data, and convective velocity–scale estimates are consistent with the meteorological model. Our work demonstrates that biologging offers a novel alternative approach for estimating atmospheric conditions on a spatial and temporal scale that complements existing meteorological measurement systems.
A Method to Assess the Wind and Solar Resource and to Quantify Interannual Variability over the United States under Current and Projected Future Climate
Authors: Haupt Sue Ellen , Copeland Jeffrey , Cheng William Y. Y. , Zhang Yongxin , Ammann Caspar , Sullivan Patrick 
Published: October 2015

AbstractThe National Center for Atmospheric Research and the National Renewable Energy Laboratory (NREL) collaborated to develop a method to assess the interannual variability of wind and solar power over the contiguous United States under current and projected future climate conditions, for use with NREL’s Regional Energy Deployment System (ReEDS) model. The team leveraged a reanalysis-derived database to estimate the wind and solar power resources and their interannual variability under current climate conditions (1985–2005). Then, a projected future climate database for the time range of 2040–69 was derived on the basis of the North American Regional Climate Change Assessment Program (NARCCAP) regional climate model (RCM) simulations driven by free-running atmosphere–ocean general circulation models. To compare current and future climate variability, the team developed a baseline by decomposing the current climate reanalysis database into self-organizing maps (SOMs) to determine the predominant modes of variability. The current climate patterns found were compared with those of an NARCCAP-based future climate scenario, and the CRCM–CCSM combination was chosen to describe the future climate scenario. The future climate scenarios’ data were projected onto the Climate Four Dimensional Data Assimilation reanalysis SOMs. The projected future climate database was then created by resampling the reanalysis on the basis of the frequency of occurrence of the future SOM patterns, adjusting for the differences in magnitude of the wind speed or solar irradiance between the current and future climate conditions. Comparison of the changes in the frequency of occurrence of the SOM modes between current and future climate conditions indicates that the annual mean wind speed and solar irradiance could be expected to change by up to 10% (increasing or decreasing regionally).