bluuebunny/crossref_metadata_2025_split huggingface dataset:
Live time-lapse dataset of in vitro wound healing experiments
Authors: Zaritsky Assaf , Natan Sari , Kaplan Doron , Ben-Jacob Eshel , Tsarfaty Ilan 
Published: February 2015

Abstract

Background
The wound healing assay is the common method to study collective cell migration in vitro. Computational analyses of live imaging exploit the rich temporal information and significantly improve understanding of complex phenomena that emerge during this mode of collective motility. Publicly available experimental data can allow application of new analyses to promote new discoveries, and assess algorithms' capabilities to distinguish between different experimental conditions.

Findings
A freely-available dataset of 31 time-lapse in vitro wound healing experiments of two cell lines is presented. It consists of six different experimental conditions with 4–6 replicates each, gathered to study the effects of a growth factor on collective cell migration. The raw data is available at ‘The Cell: an Image Library' repository. This Data Note provides detailed description of the data, intermediately processed data, scripts and experimental validations that have not been reported before and are currently available at GigaDB. This is the first publicly available repository of live collective cell migration data that includes independent replicates for each set of conditions.

Conclusions
This dataset has the potential for extensive reuse. Some aspects in the data remain unexplored and can be exploited extensively to reveal new insight. The dataset could also be used to assess the performance of available and new quantification methods by demonstrating phenotypic discriminatory capabilities between the different experimental conditions. It may allow faster and more elaborated, reproducible and effective analyses, which will likely lead to new biological and biophysical discoveries.
Kidney injury molecule-1 as a predicting factor for inflamed kidney, diabetic and diabetic nephropathy Egyptian patients
Authors: Ahmed Samia A , Hamed Manal A 
Published: February 2015

Abstract
Background
Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated proximal renal tubular epithelial cells in damaged regions. Kidney injury early detection in diabetic patients has great importance for therapy and prognosis. Therefore, the aim of the present study is to predict, validate and evaluate the presence of KIM-1 in kidney inflammation, dialectic and diabetic nephropathy diseases.

Methods
Sixty males and females subjects (30-52 years) were selected for this study. They were subdivided into three main groups; kidney injury, diabetic and diabetic nephropathy patients. The work was extended to evaluate KIM-1 after treatment of each disease.

Results
The results revealed significant elevation of KIM-1 in the diseased groups and a noticeable reduction after treatment. Diabetic nephropathy recorded the highest KIM-1 level than the AKI state or the diabetic patients. We noticed an association between KIM-1 and sex and a positive correlation (p < 0.0001) with the disease severity.

Conclusions
In conclusion, urinary KIM-1 has been reported to be a noninvasive, rapid, sensitive, and reproducible biomarker to detect early kidney injury. We speculate that KIM-1 is expected to be a therapeutic target for kidney injury.
Pretreatment of garden biomass using Fenton’s reagent: influence of Fe2+ and H2O2 concentrations on lignocellulose degradation
Authors: Bhange Vivek P , William SPM Prince , Sharma Abhinav , Gabhane Jagdish , Vaidya Atul N , Wate Satish R 
Published: February 2015

AbstractGarden biomass (GB) is defined as low density and heterogeneous waste fraction of garden rubbish like grass clippings, pruning, flowers, branches, weeds; roots. GB is generally different from other types of biomass. GB is mostly generated through maintenance of green areas. GB can be processed for bio energy production as it contains considerably good amount of cellulose and hemicellulose. However, pretreatment is necessary to delignify and facilitate disruption of cellulosic moiety. The aim of the present investigation was to pretreat GB using Fenton’s reagent and to study the influence of Fe2+and H2O2concentrations on degradation of lignin and cellulose. The data were statistically analyzed using ANOVA and numerical point prediction tool of MINITAB RELEASE 14 to optimize different process variables such as temperature, concentration of Fe2+and H2O2. The results of the present investigation showed that Fenton’s reagent was effective on GB, however, concentration of Fe2+and H2O2play crucial role in determining the efficiency of pretreatment. An increase in H2O2concentration in Fenton’s reagent significantly increased the rate of cellulose and lignin degradation in contrast to increasing concentration of Fe2+ion which led to a decrease in lignocellulosic degradation.
Cephalometric study to test the reliability of anteroposterior skeletal discrepancy indicators using the twin block appliance
Authors: Trivedi Rahul , Bhattacharya Amit , Mehta Falguni , Patel Dolly , Parekh Harshik , Gandhi Vaibhav 
Published: February 2015

Abstract

Background
The objectives of this study were to check the reliability of the five angular and two linear parameters for sagittal maxillo-mandibular discrepancy and to compare and correlate angular parameters with the ANB angle, and the linear parameter with Wits analysis.

Methods
The pre-treatment and post-functional lateral cephalograms of 25 subjects (17 males, 8 females) with class II division 1 malocclusion treated with twin block functional appliance were selected. Five angular (ANB, β angle, APDI, YEN angle, W angle) and two linear (Wits analysis, App-Bpp) parameters were traced on both sets of cephalograms. Paired Student’s t-test, one-way ANOVA, post hoc test, and Karl Pearson correlation statistical analysis were performed.

Results
All the parameters considered in our study showed highly significant difference in pre-treatment and post-functional values, suggesting their reliability (p < 0.0001). When ANB angle was compared with the other angular parameters, a highly significant change in the mean value of the difference in pre-treatment (T1) and post-functional (T2) values was noted (p < 0.001). No significant change was seen when comparing the mean value of the difference in T1 and T2 between linear parameters (p = 0.949).

Conclusions
All the parameters used in the study can be reliably used to assess anteroposterior skeletal discrepancy. Whenever limitations of the ANB angle and Wits analysis are foreseen, the W angle and App-Bpp, respectively, can be reliably used. The YEN angle may reliably predict the post-functional change with the use of twin block appliance.
Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats
Authors: Shih Shen-Liang , Lin Yin-Shiou , Lin Shyr-Yi , Hou Wen-Chi 
Published: February 2015

Abstract

Background
The metabolic syndrome (MS) is termed a cluster of multiple metabolic risk criteria which is positively correlated with cardiovascular disease and type 2 diabetes mellitus (DM). Yam dioscorins have been reported to exhibit biological activities, however, little is known their preventive effects on the MS. Therefore, a high-fat (HF) diet was used to induce Wistar rat obesity and then yam dioscorin (50 mg/kg, dio50) was intervened daily concurrent HF diet (HF diet + dio50) for five weeks to check the changes of weights of body and tissues, blood pressures, and impaired glucose tolerances. The in vitro peptic hydrolysates of dioscorin with molecular mass between 3 kDa and 10 kDa and less than 3 kDa were used to determine dipeptidyl peptidase IV (DPP IV) inhibitory activities which DPP IV inhibitor has been reported to prevent and treat type 2 DM.

Results
There were no significant difference in body weights, feed intakes, feed conversion, and weights of adipose tissues of obese rats in groups of HF and (HF diet + dio50). However, the systolic blood pressures in obese rats of 2-, 3- and 4-week dioscorin interventions were showed significantly lower (P < 0.05) compared to the HF group. The dioscorin intervention (HF+ dio50) was showed significantly different (P < 0.05) and improved the impaired glucose tolerances compared to HF group in obese rats by the oral glucose tolerance tests. It was also found that the fraction with different molecular mass of dioscorin peptic hydrolysates (5 mg/ml) showed inhibitory activities against DPP IV using sitagliptin phosphate as positive controls.

Conclusions
Yam dioscorins exhibit improved MS activities in obese rats which the related mechanisms may need further investigations.
Dapagliflozin Lowers Plasma Glucose Concentration and Improves β-Cell Function
Authors: Merovci Aurora , Mari Andrea , Solis Carolina , Xiong Juan , Daniele Giuseppe , Chavez-Velazquez Alberto , Tripathy Devjit , Urban McCarthy Scheherezada , Abdul-Ghani Muhammad , DeFronzo Ralph A. 
Published: February 2015

Abstract

Background:
β-Cell dysfunction is a core defect in T2DM, and chronic, sustained hyperglycemia has been implicated in progressive β-cell failure, ie, glucotoxicity. The aim of the present study was to examine the effect of lowering the plasma glucose concentration with dapagliflozin, a glucosuric agent, on β-cell function in T2DM individuals.

Research Design and Methods:
Twenty-four subjects with T2DM received dapagliflozin (n = 16) or placebo (n = 8) for 2 weeks, and a 75-g oral glucose tolerance test (OGTT) and insulin clamp were performed before and after treatment. Plasma glucose, insulin, and C-peptide concentrations were measured during the OGTT.

Results:
Dapagliflozin significantly lowered both the fasting and 2-hour plasma glucose concentrations and the incremental area under the plasma glucose concentration curve (ΔG0–120) during OGTT by −33 ± 5 mg/dL, −73 ± 9 mg/dL, and −60 ± 12 mg/dL · min, respectively, compared to −13 ± 9, −33 ± 13, and −18 ± 9 reductions in placebo-treated subjects (both P &lt; .01). The incremental area under the plasma C-peptide concentration curve tended to increase in dapagliflozin-treated subjects, whereas it did not change in placebo-treated subjects. Thus, ΔC-Pep0–120/ΔG0–120 increased significantly in dapagliflozin-treated subjects, whereas it did not change in placebo-treated subjects (0.019 ± 0.005 vs 0.002 ± 0.006; P &lt; .01). Dapagliflozin significantly improved whole-body insulin sensitivity (insulin clamp). Thus, β-cell function, measured as ΔC-Pep0–120/ ΔG0–120 ÷ insulin resistance, increased by 2-fold (P &lt; .01) in dapagliflozin-treated vs placebo-treated subjects.

Conclusion:
Lowering the plasma glucose concentration with dapagliflozin markedly improves β-cell function, providing strong support in man for the glucotoxic effect of hyperglycemia on β-cell function.
Research Resource: The Dynamic Transcriptional Profile of Sertoli Cells During the Progression of Spermatogenesis
Authors: Zimmermann Céline , Stévant Isabelle , Borel Christelle , Conne Béatrice , Pitetti Jean-Luc , Calvel Pierre , Kaessmann Henrik , Jégou Bernard , Chalmel Frédéric , Nef Serge 
Published: February 2015

AbstractSertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately with developing germ cells. They not only provide physical and nutritional support but also secrete factors essential to the complex developmental processes of germ cell proliferation and differentiation. The SC transcriptome must therefore adapt rapidly during the different stages of spermatogenesis. We report comprehensive genome-wide expression profiles of pure populations of SCs isolated at 5 distinct stages of the first wave of mouse spermatogenesis, using RNA sequencing technology. We were able to reconstruct about 13 901 high-confidence, nonredundant coding and noncoding transcripts, characterized by complex alternative splicing patterns with more than 45% comprising novel isoforms of known genes. Interestingly, roughly one-fifth (2939) of these genes exhibited a dynamic expression profile reflecting the evolving role of SCs during the progression of spermatogenesis, with stage-specific expression of genes involved in biological processes such as cell cycle regulation, metabolism and energy production, retinoic acid synthesis, and blood-testis barrier biogenesis. Finally, regulatory network analysis identified the transcription factors endothelial PAS domain-containing protein 1 (EPAS1/Hif2α), aryl hydrocarbon receptor nuclear translocator (ARNT/Hif1β), and signal transducer and activator of transcription 1 (STAT1) as potential master regulators driving the SC transcriptional program. Our results highlight the plastic transcriptional landscape of SCs during the progression of spermatogenesis and provide valuable resources to better understand SC function and spermatogenesis and its related disorders, such as male infertility.
Synthesis and Properties of (Terthiophene)4–Poly(amidoamine)–C60 Pentad
Authors: Tajima Tomoyuki , Nishihama Takuya , Miyake Shogo , Takahashi Nobuhiro , Takaguchi Yutaka 
Published: February 2015

Abstract
(Terthiophene)4–poly(amidoamine)–C60 pentad 8a and (terthiophene)2–poly(amidoamine)–C60 triad 8b have been synthesized with the aim of developing novel precursors for photoinduced polymerization. The electrochemical oxidation of pentad 8a by repetitive cyclic voltammogram scans gave a polymeric 8a film on a FTO electrode, which showed electrochemical activity and photoelectric response. When a monomer film of 8 on FTO was irradiated with visible light, the photoinduced polymerization of the terthiophene moiety was observed. The photoanodic features of an electropolymerized film of 8a on a FTO (poly-8aelectro/FTO) and 8a/FTO were investigated regarding photocurrent response to light irradiation. The photocurrent of a photopolymerized 8a film on a FTO (poly-8aphoto/FTO) electrode formed by photoreaction of 8a/FTO, is approximately 6 times greater than that of the 8a/FTO electrode.
Retreating in/from art institutions
Authors: Anderson Heather 
Published: February 2015

Abstract
All too frequently individuals working in art institutions are faced with the frustrating contradiction that the quality engagement with art and ideas that are the institution's raison d'être, and the concentrated research and writing that are a vital part of, for instance, curatorial work are compromised by workload and have to be eked out in less-than-efficient spurts, fit in after regular working hours, or postponed altogether. This text explores some of the reasons conditions of overwork exist in art institutions and how slow time for working with art, artists and ideas might be reprioritized by looking at recent examples of art institutions that have employed strategies of retreat and withdrawal. The text also proposes that given the prevalence and normalization of conditions of overwork as well as an increasing reliance on unpaid labour in the field, art institutions have an ethical responsibility to refuse such exploitative conditions and commit to doing less when human and financial resources are insufficient.
The Daily Sleeper (excerpts); 10/08/12
Authors: Bristol Joanne 
Published: February 2015

Abstract
Through a desire to articulate modes of multispecies agency, data were gathered in response to material, spatial and temporal qualities of Sleeping Buffalo (Tunnel) mountain - or iniskim - during The Retreat residency at the Banff Centre. In an attempt to 'retreat' from forms exclusive to art, data are presented using the ubiquitous structures of 'newspaper' and 'postcard'.
Reviews
Authors: Loydell Rupert , Dale Pete 
Published: February 2015

Abstract
Future Days. Krautrock and the Building of Modern Germany, David Stubbs (2014) Faber, London, 495 pp., ISBN: 9780571283323, p/bk, £20.00
Fight Back: Punk, Politics and Resistance, The Subcultures Network (2015) Manchester: Manchester University Press, 319 pp., ISBN: 9780719090295, h/bk, £75
Development of Inexpensive SiGe–FeSi2 Thermoelectric Nanocomposites
Authors: Abudakka Mohamed , Nozariasbmarz Amin , Tayebi Lobat , Krasisnki Jerzy S. , Vashaee Daryoosh 
Published: February 2015

Abstract
This investigation presents cost-effective fabrication of n-type silicon germanium–iron disilicide nanocomposites using low-cost low-purity germanium–germanium oxide powder. Moreover, the probability of the reduction of oxide powders during the synthesis process was studied. X-ray diffraction (XRD) analysis indicated reduction of germanium oxide impurity in the synthesized material. Scanning electron microscopy (SEM) along with the energy-dispersive spectrometer (EDS) showed a structure of dispersed iron disilicide particles embedded in silicon germanium matrix. The nanocomposite structure showed a moderate figure-of-merit, ZT, equal to 0.8. The ZT enhancement was related to both the nanocomposite structure and the reduction of germanium oxide.
Extending Constructivist Perspectives on Opportunity Production Through An Incorporation of Effectual Logics
Authors: Metzger Matthew L. , King Jesse S. 
Published: February 2015

AbstractCurrent constructivist theorizing relies heavily on causal logics and, therefore, posits that entrepreneurs either pursue or abandon perceived opportunities shortly after their inception. However, findings from effectuation research illuminate less-direct processes involved in the establishment of entrepreneurial ventures. We describe how effectual and causal logics might be integrated by proposing a supplemented model of entrepreneurial opportunity production that features an alternative effectual pathway. In describing this model, we develop six propositions to explain the unique pattern of cognitions and behaviors found among entrepreneurs employing effectual logics. Our propositions suggest that these entrepreneurs are unlikely to rely on peer feedback to determine the viability of early stage opportunities. Instead, they delay the objectification and evaluation of opportunities because they recognize that predictions made in uncertain environments are unlikely to be correct. The employment of these alternate logics results in different pathways to commercialization and different consequences associated with failures.
Negative Selection of Artificial Immune Applied to Voltage Inadequacy Detection in Distribution Networks
Authors: Delboni Luiz Fernando , Zambroni da Silva Antonio Carlos , Oliveira Denisson Queiroz 
Published: February 2015

Abstract
The problem of voltage control and reactive power management plays a crucial role on power system’s operations. Particularly, detecting the most effective control actions to reduce the system loss and enhance the voltage profile is of major interest. This paper deals with system voltage inadequacy detection. To address this problem, artificial immune system is employed considering its negative selection mechanism. Its purpose is to monitor system operation data entry and check if the voltage level is within its operating values. In this sense, the user may define the range of control, so the proposed methodology may be useful for normal and emergency operating conditions. Corrective actions are undertaken if necessary. The IEEE 34 nodes distribution system is used to test the proposed methodology.
Estimation of heat loss from a cylindrical cavity receiver based on simultaneous energy and exergy analyses
Authors: Madadi Vahid , Tavakoli Touraj , Rahimi Amir 
Published: February 2015

Abstract
This study undertakes the experimental and theoretical investigation of heat
losses from a cylindrical cavity receiver employed in a solar parabolic dish
collector. Simultaneous energy and exergy equations are
used for a thermal performance analysis of the system. The effects of wind speed and its direction
on convection loss has also been investigated.
The effects of operational parameters, such as heat transfer fluid mass flow rate and wind speed, and
structural parameters, such as receiver geometry and inclination, are
investigated. The portion of radiative heat loss is less than 10%.
An empirical and simplified correlation for estimating the dimensionless
convective heat transfer coefficient in terms of the

Re

$\mathrm {Re}$

number and the average
receiver wall temperature is proposed. This correlation is applicable for
a wind speed range of

0
.
1

$0.1$

to 10 m/s. Moreover, the proposed correlation for

Nu

$\mathrm {Nu}$

number
is validated using experimental data obtained through the experiments
carried out with a conical receiver with two aperture diameters.
The coefficient of determination R
2 and the normalized root mean square error (NRMSE) parameters were calculated, and the results show that there is a good agreement between predicted results
and experimental data. R
2 is greater than

0
.
95

$0.95$

and the NRMSE parameters
is less than

0
.
06

$0.06$

in this analysis.
Study of triplet periodicity differences inside and between genomes
Authors: Suvorova Yulia M. , Korotkov Eugene V. 
Published: February 2015

AbstractTriplet periodicity (TP) is a distinctive feature of the protein coding sequences of both prokaryotic and eukaryotic genomes. In this work, we explored the TP difference inside and between 45 prokaryotic genomes. We constructed two hypotheses of TP distribution on a set of coding sequences and generated artificial datasets that correspond to the hypotheses. We found that TP is more similar inside a genome than between genomes and that TP distribution inside a real genome dataset corresponds to the hypothesis which implies that a common TP pattern exists for the majority of sequences inside a genome. Additionally, we performed gene classification based on TP matrixes. This classification showed that TP allows identification of the genome to which a given gene belongs with more than 85% accuracy.
Hyperfeinstruktur von AlJ / Hyperfine Structure of AlI
Authors: Törring T. , Tiemann E. , Hoeft J. 
Published: February 2015

The quadrupole hyperfine structure of 27A1127I was measured on the rotational transition J = 1 → 2 and 14 GHz. Observations in various vibrational states resulted in the following quadrupole coupling constants:
eq0Q (27Al) =-25.50(10) MHz,
eqvQ{127I) =-307.407-4.315 (ν+1/2) ±0.100 MHz.
The magnetic spin-rotation-interaction of the iodine nucleous was included in the calculation. We obtained as coupling constant:
cI (127I) = + 13.3(10) kHz.