bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniform Gaussian Bounds for Subelliptic Heat Kernels
and an Application to the Total Variation Flow of
Graphs over Carnot Groups
Authors: Capogna Luca , Citti Giovanna , Manfredini Maria 
Published: August 2013

Abstract
In this paper we study heat kernels associated with a Carnot
group G, endowed with a family of collapsing left-invariant
Riemannian metrics σε which converge in the Gromov-
Hausdorff sense to a sub-Riemannian structure on G as ε→
0. The main new contribution are Gaussian-type bounds on
the heat kernel for the σε metrics which are stable as ε→0
and extend the previous time-independent estimates in [16].
As an application we study well posedness of the total variation
flow of graph surfaces over a bounded domain in a step
two Carnot group (G; σε ). We establish interior and boundary
gradient estimates, and develop a Schauder theory which are
stable as ε → 0. As a consequence we obtain long time
existence of smooth solutions of the sub-Riemannian flow
(ε = 0), which in turn yield sub-Riemannian minimal surfaces
as t → ∞.
Les ambiguïtes de la dématérialisation des procédures en droit des étrangers
Authors: Tchen Vincent 
Published: August 2013

Résumé	Le bilan de la téléprocédure en droit des étrangers s’avère doublement décevant. Il porte tout d’abord sur un nombre restreint de formalités applicables, pour l’essentiel, aux demandes de visa et de titre de séjour. Les motifs qui ont animé les pouvoirs publics ont par ailleurs perturbé les effets de ces modestes initiatives. Celles‑ci ont le plus souvent été dénuées d’une véritable volonté d’améliorer les rapports entre une autorité en charge d’une mission de puissance publique et des usagers placés dans une situation toute singulière.
Les téléservices publics face au droit à la confidentialité des données
Authors: Cluzel-Métayer Lucie 
Published: August 2013

Résumé	L’essor considérable des téléservices publics appelle une réflexion sur l’efficacité de la protection accordée au droit à la confidentialité des données personnelles des usagers. Tout porte à croire que ces derniers ont une maîtrise très relative de leurs propres données, tant concernant la collecte, le traitement et l’échange de ces données entre administrations que concernant leur réutilisation en dehors de tout téléservice public. Le droit à la confidentialité passe ainsi davantage par la sécurisation des échanges et des systèmes d’information, reposant sur un cadre juridique et technique difficile à stabiliser.
Droits des administrés internautes et téléservices publics
Authors: Perroud Thomas 
Published: August 2013

Résumé	Les téléservices publics entretiennent des relations complexes avec les droits des usagers. Apparaissant d’emblée comme une menace pour leurs droits fondamentaux ainsi que pour l’égalité des citoyens, ils se présentent aussi comme une promesse ; promesse pour la pérennité des services publics dans un contexte difficile économiquement, promesse d’approfondissement des droits existants que porte le service public, promesse enfin de concrétisation des nouveaux droits du service public et d’une nouvelle citoyenneté administrative. Cette ambiguïté fondamentale est au cœur des téléservices publics.
L'administration électronique, support de l'innovation dans les services publics
Authors: Ubaldi Barbara 
Published: August 2013

Résumé	Les technologies de l’information et de la communication (TIC) offrent un potentiel énorme pour l’innovation dans la façon dont les gouvernements fonctionnent et fournissent des services publics. Les succès dans l’amélioration de la disponibilité et de la qualité des services publics en ligne ont souvent été atteints contre toute attente et malgré les défis spécifiques au secteur public. La rapidité du développement des technologies, la complexité des tâches des gouvernements et les nombreux acteurs impliqués dans la conception et la prestation des services illustrent les défis auxquels les gouvernements à travers le monde doivent faire face. Cet article examine les principaux développements dans l’utilisation des technologies de l’information et de la communication qui favorisent l’innovation dans la prestation des services publics et met en évidence quelques‑uns des défis qui subsistent.
Immunization with a Chimera Consisting of the B Subunit of Shiga Toxin Type 2 and Brucella Lumazine Synthase Confers Total Protection against Shiga Toxins in Mice
Authors: Mejias María P. , Ghersi Giselle , Craig Patricio O. , Panek Cecilia A. , Bentancor Leticia V. , Baschkier Ariela , Goldbaum Fernando A. , Zylberman Vanesa , Palermo Marina S. 
Published: August 2013

Abstract
The striking feature of enterohemorrhagic Escherichia coli (EHEC) infections is the production of Shiga toxins (Stx) implicated in the development of the life-threatening hemolytic uremic syndrome. Despite the magnitude of the social impact of EHEC infections, no licensed vaccine or effective therapy is available for human use. One of the biggest challenges is to develop an effective and safe immunogen to ensure nontoxicity, as well as a strong input to the immune system to induce long-lasting, high-affinity Abs with anti-Stx–neutralizing capacity. The enzyme lumazine synthase from Brucella spp. (BLS) is a highly stable dimer of pentamers and a scaffold with enormous plasticity on which to display foreign Ags. Taking into account the advantages of BLS and the potential capacity of the B subunit of Stx2 to induce Abs that prevent Stx2 toxicity by blocking its entrance into the host cells, we engineered a new immunogen by inserting the B subunit of Stx2 at the amino termini of BLS. The resulting chimera demonstrated a strong capacity to induce a long-lasting humoral immune response in mice. The chimera induced Abs with high neutralizing capacity for Stx2 and its variants. Moreover, immunized mice were completely protected against i.v. Stx2 challenge, and weaned mice receiving an oral challenge with EHEC were completely protected by the transference of immune sera. We conclude that this novel immunogen represents a promising candidate for vaccine or Ab development with preventive or therapeutic ends, for use in hemolytic uremic syndrome–endemic areas or during future outbreaks caused by pathogenic strains of Stx-producing E. coli.
CA-125 and risk of malignancy index for screening for malignancy in fertile aged females with ovarian cyst, which is more cost effectiveness?
Authors: Wiwanitkit Viroj 
Published: August 2013

Abstract
Background: Ovarian tumor is a cause of infertility in the fertile-aged women. Also, it can also turns into malignancy and causes deadly outcome. Screening for malignancy is an important management. Aims: The available screening methods that are widely used at present include CA-125 determination and the risk of malignancy index (RMX), which is a combined CA-125 with ultrasonography, determination. Materials and Methods: Here, the author tries to assess cost-effectiveness of both alternative in screening by basic medical economics technique. Statistics: Classical descriptive analysis was used for cost effectiveness calculation. Results: In this work, from the cost-effectiveness analysis, the CA-125 test is more cost-effectiveness than RMX. Conclusion: This reflects that the usage of additional ultrasonography test for increasing the diagnostic activity in screening for ovarian cyst in the fertile aged females in Thailand is still not appropriate.
Serum galactomannan assay for diagnosis of probable invasive Aspergillosis in acute leukemia and hematopoietic stem cell transplantation
Authors: Ghosh Indranil , Raina Vinod , Kumar Lalit , Sharma Atul , Bakhshi Sameer , Iqbal Sobuhi 
Published: August 2013

Abstract
Background: Invasive aspergillosis (IA) is a leading cause of mortality in acute leukemia and hematopoietic stem cell transplantation (HSCT). Aims: To determine the yield of galactomannan (GM) assay for the diagnosis of probable IA, its temporal relationship with the computed tomography (CT) scans and correlation with mortality in AL and HSCT. Patients and Methods: Consecutive neutropenic episodes (n=150) among inpatients aged ≥15 years with AL or recipients of HSCT were prospectively evaluated over 1΍ years. All patients underwent weekly serum GM assay and optical density index >0.5 for ≥2 samples was defined as positive. IA was diagnosed according to EORTC 2008 guidelines. Results: Of the 150 episodes enrolled, 43 (28.7%) were diagnosed with IA: possible 25 (16.7%), probable 17 (11.3%) and proven 1 (0.7%). The yield of GM assay in diagnosing probable IA was 17/42 (40.5%). In 88.2% of probable IA episodes, GM was positive before high-resolution CT at a median of 10 days (range 1-16). In the episodes with ≥2 samples tested, fatality was higher in those ≥2 values positive for GM, compared to the rest (31% vs. 13.2%, odd ratio 2.96, 95% CI 1.09-8.00; P=0.04). Conclusions: In AL and HSCT, GM assay could identify patients with probable IA earlier than CT chest and also predicted a higher risk of death.
Subcutaneous panniculitis-like T-cell lymphoma in a case of carcinoma cervix
Authors: Swain Meenakshi , Swarnalata Gowrishankar , Bhandari Trilok 
Published: August 2013

AbstractSubcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon extra nodal non-Hodgkin lymphoma accounting for less than 1% of all NHLs known to have an aggressive course, with no well-defined treatment protocols. A 42-year-old lady, operated five months earlier for a squamous cell carcinoma of the cervix presented with pain and induration of the lower part of the anterior abdominal wall; 3 months after completing chemotherapy and radiotherapy. FNAC done, yielded scanty material and was inconclusive. The biopsy showed features of a subcutaneous panniculitis-like T-cell lymphoma. While on chemotherapy she developed a vault recurrence and extensive intra-abdominal spread of the squamous cell carcinoma and succumbed. SPTCL is a rare entity and has been reported in renal and cardiac allograft recipients and in one case of ovarian carcinoma. Its occurrence in the setting of carcinoma cervix is unusual, hence is being reported.
Management of isolated recurrence of extramedullary myeloid tumor at a single site
Authors: Krishna Muddu Vamshi , Yadav Ashok K. , Arora Brijesh , Banavali Shripad D. 
Published: August 2013

AbstractExtramedullary myeloid tumors (EMMT) can precede, occur with or follow AML. Rarely, they can present as isolated relapses. We present a 9-year-old child with t (8, 21) positive AML who was treated with induction regimen and achieved remission. While on high-dose cytarabine consolidation, he had isolated relapse in a single cervical lymph node with uninvolved marrow. He was treated with salvage chemotherapy alone. There are no clear guidelines for treatment of isolated extramedullary relapse. Chemotherapy, radiotherapy followed by stem cell transplant is the usual option. Our patient is unique for the unusual site of relapse and prolonged remission with cladribine-based chemotherapy, mitoxantrone-based consolidation, and oral maintenance therapy.
Oesophageal carcinoma presenting with a synchronous asymptomatic colon carcinoma
Authors: Gupta Alok , Chauhan Bharat , Rangarajan V , Desai Saral , Noronha Vanita , Prabhash Kumar 
Published: August 2013

AbstractThe advancement in diagnostic techniques has resulted in increased incidence of occult second primary in cancer patients. Here, we report a case of symptomatic oesophageal carcinoma and synchronous asymptomatic colon carcinoma diagnosed through Positron Emission Tomography-Computed Tomography imaging.
Stage IV lung cancer: Is cure possible?
Authors: Thippeswamy Ravi , Noronha Vanita , Krishna Vamshi , Joshi Amit , Bal Munita Meenu , Purandare Nilendu , Rangarajan V , Pramesh C.S. , Jiwnani Sabita , Prabhash Kumar 
Published: August 2013

AbstractReporting a case, 53 years old male with stage IV Nonsamall cell lung cancer in view of cytologically proven malignant pleural effusion. Usually the management of stage IV lung cancer is with palliative intent where the patient receives palliative chemotherapy along with palliative radiotherapy and surgery if required. Most of the data on curative management of oligometastatic non-small cell lung cancer includes patient with adrenal metastasis and some reports with brain metastasis. There is scarce literature on the surgical management of stage IV lung cancer with pleural effusion.
Mediastinal ganglioneuroma: An incidentaloma of childhood
Authors: Shukla Ram Mohan , Mukhopadhyay Biswanath , Mukhopadhyay Madhumita , Mandal Kartik Chandra 
Published: August 2013

AbstractGanglioneuroma is a rare benign neurogenic tumor which represents the final maturation stage of neuroblast tumors. Here, we are discussing an interesting case of incidentally detected posterior mediastinal ganglioneuroma which should be kept in mind when dealing with any child with respiratory distress.
Orbital and infratemporal fossa metastasis: An unusual initial presentation of adenocarcinoma of lung
Authors: Chaudhuri Tamojit , Yadava Kamlesh 
Published: August 2013

AbstractOrbital metastasis as initial presentation of adenocarcinoma of lung is an extremely rare phenomenon. Here, we report a 46-year-old non-smoker Asian woman, who presented with right eye proptosis due to right orbital and infratemporal fossa metastasis, as the first presentation of adenocarcinoma of right lung.
STRAIN-CONTROLLED BIAXIAL TENSION OF NATURAL RUBBER: NEW EXPERIMENTAL DATA
Authors: Pancheri Francesco Q. , Dorfmann Luis 
Published: August 2013

ABSTRACT
We present a new experimental method and provide data showing the response of 40A natural rubber in uniaxial, pure shear, and biaxial tension. Real-time biaxial strain control allows for independent and automatic variation of the velocity of extension and retraction of each actuator to maintain the preselected deformation rate within the gage area of the specimen. We also focus on the Valanis–Landel hypothesis that is used to verify and validate the consistency of the data. We use a three-term Ogden model to derive stress–stretch relations to validate the experimental data. The material model parameters are determined using the primary loading path in uniaxial and equibiaxial tension. Excellent agreement is found when the model is used to predict the response in biaxial tension for different maximum in-plane stretches. The application of the Valanis–Landel hypothesis also results in excellent agreement with the theoretical prediction.
REINFORCEMENT OF NATURAL RUBBER BY PRECIPITATED SILICA: THE INFLUENCE OF PROCESSING TEMPERATURE
Authors: Sarkawi S. Salina , Dierkes Wilma K. , Noordermeer Jacques W. M. 
Published: August 2013

ABSTRACT
The thermal history, and in particular the mixing dump temperature, is a parameter of paramount importance in mixing rubber and silica with a silane coupling agent in order to achieve proper silanization of silica and to avoid premature scorch reactions. The influence of the mixing dump temperature on the performance of silica-reinforced natural rubber (NR) is investigated. The investigation also includes the effect of nonrubber constituents, primarily proteins in NR, by using deproteinized natural rubber (DPNR) and synthetic polyisoprene (IR). The vulcanization properties and rubber-to-filler interactions of silica-reinforced NR in the presence and absence of a silane coupling agent are highlighted. With increasing mixing dump temperature, the silanization reaction between silica and silane coupling agent proceeds further. At a sufficiently high dump temperature, filler–filler interactions in the NR–silica compounds are reduced and the silica–rubber interaction improved, as evidenced by a drop in the Payne effect and increment in chemically bound rubber. It is demonstrated that NR and IR compounds mixed until they are above the optimum dump temperature exhibit cure reversion and reduction in tensile properties. On the other hand, DPNR–silica vulcanizates show slightly more constant physical properties.
Lipid and Lipoprotein Levels and Trend in Rheumatoid Arthritis Compared to the General Population
Authors: Liao Katherine P. , Cai Tianxi , Gainer Vivian S. , Cagan Andrew , Murphy Shawn N. , Liu ChihChin , Churchill Susanne , Shaw Stanley Y. , Kohane Isaac , Solomon Daniel H. , Plenge Robert M. , Karlson Elizabeth W. 
Published: August 2013

ObjectiveDifferences in lipid levels associated with cardiovascular (CV) risk between rheumatoid arthritis (RA) patients and the general population remain unclear. Determining these differences is important in understanding the role of lipids in CV risk in RA.MethodsWe studied 2,005 RA subjects from 2 large academic medical centers. We extracted electronic medical record data on the first low‐density lipoprotein (LDL) measurement, and total cholesterol and high‐density lipoprotein (HDL) measurements within 1 year of the LDL measurement. Subjects with an electronic statin prescription prior to the first LDL measurement were excluded. We compared lipid levels in RA patients to recently published levels from the general US population using the t‐test and stratifying by published parameters, i.e., 2007–2010, and women. We determined lipid trends using separate linear regression models for total cholesterol, LDL cholesterol, and HDL cholesterol, testing the association between year of measurement (1989–2010) and lipid level, adjusted by age and sex. Lipid trends in RA were qualitatively compared to the published general population trends.ResultsWomen with RA had a significantly lower total cholesterol (186 versus 200 mg/dl; P = 0.002) and LDL cholesterol (105 versus 118 mg/dl; P = 0.001) compared to the general population (2007–2010). HDL cholesterol was not significantly different in the 2 groups. In the RA cohort, total cholesterol and LDL cholesterol significantly decreased each year, while HDL cholesterol increased (all with P < 0.0001), consistent with overall trends observed in a previous study.ConclusionRA patients appear to have an overall lower total cholesterol and LDL cholesterol than the general population despite the general overall risk of CV disease in RA from observational studies.
Effects of Cardiovascular Comorbidities on Work Participation in Rheumatic Diseases: A Prospective Cohort Study Among Working Individuals
Authors: van der Burg Lennart R. A. , Boonen Annelies , van Amelsvoort Ludovic G. P. M. , Jansen Nicole W. H. , Landewé Robert B. M. , Kant Ijmert 
Published: August 2013

ObjectiveTo determine the risk of sick leave and work disability in relation to rheumatic diseases and cardiovascular comorbidities among working individuals.MethodsEmployees (n = 12,140) from 45 companies in The Netherlands were prospectively followed up from 1998–2008. Questionnaires were used to assess self‐reported diseases and employment status. Company records provided individual sick leave data for the first 2.5 years of followup. For a selected sample of the cohort (50%), verification of self‐reported diseases was sought through hospital record linkage. Poisson regressions and Cox proportional hazards models were applied to determine the impact of both self‐reported and verified diseases on sick leave and work disability, respectively.ResultsThe number of days and frequency of sick leave were increased in working individuals with self‐reported rheumatic and cardiovascular disease (P < 0.001), but self‐reported cardiovascular comorbidity did not result in more sick leave in those who also self‐reported rheumatic disease. Work disability was also increased for both self‐reported rheumatic disease and cardiovascular disease (P < 0.001), but again, no additive effects were found. In the sample verified by clinical review, the frequency or number of days of sick leave was significantly higher in employees with cardiovascular disease (P < 0.001), inflammatory rheumatic disease (P < 0.05), and osteoarthritis (P < 0.05) compared to employees without these diseases. Work disability in the verified sample occurred especially in patients with osteoarthritis (hazard ratio [HR] 12.36 [95% confidence interval (95% CI) 1.59–13.66]), fibromyalgia (HR 14.24 [95% CI 2.02–16.54]), and cardiovascular disease (HR 4.88 [95% CI 1.70–14.01]).ConclusionRheumatic and cardiovascular diseases increased the risk of sick leave and work disability in a working population, but there was no indication that these effects convey an additive risk.
Polarimetric z‐Scan Study of Nonlinear Chirooptic Properties of Chiral Polyfluorene
Authors: He Guang S. , Cho Min Ju , Kim Won Jin , Baev Alexander , Urbas Augustine , Prasad Paras N. 
Published: August 2013

Chiral photonics is an emerging field which deals with enantioselective light–matter interactions, offering numerous exciting applications. Two main approaches to enhancing enantioselective interactions are currently under extensive study: 1) structuring light itself, and 2) developing materials with gigantic optical activity. Both are required to realize the full potential of this emerging field. Here, the intensity‐dependent optical activity of a chiral polyfluorene film that has been studied by using open‐ and closed‐aperture z‐scan techniques with ∼775 nm and ∼160 fs laser pulses is reported. For a film of ∼20 μm thickness, the measured two‐photon absorption coefficients are 1.24 and 1.49 cm GW‐1, respectively, and the nonlinear refractive indices are 8.74 × 10−5 and 1.38 × 10−4 cm2 GW‐1 for right and left circularly polarized laser beams, respectively. The nonlinear optical activity of pure, undoped polyfluorene is the highest reported so far.
Molecular basis of the clinical features of Al‐Awadi‐Raas‐Rothschild (limb/pelvis/uterus‐hypoplasia/aplasia) syndrome (AARRS) and Fuhrmann syndrome
Authors: Al‐Qattan M.M. 
Published: August 2013

AbstractThis paper reviews the molecular basis of the clinical features of Al‐Awadi‐Raas‐Rothschild (limb/pelvis/uterus‐hypoplasia–aplasia) (AARRS) syndrome and Fuhrmann syndrome. Human WNT7A mutations are also reviewed. Based on this review, these mutations will be classified into two main groups of phenotypes: Fuhrmann and AARRS phenotypes in which there is partial and complete loss of WNT7A functions, respectively. © 2013 Wiley Periodicals, Inc.