bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Acid-Mediated Multicomponent Domino Reaction for the Synthesis of N-Substituted Isoindolinones
Authors: Karu Sudheer Kumar , Malapaka Chandrasekharam , Veludandi Meghanath 
Published: August 2024

AbstractA one-pot multicomponent reaction of 2-carboxybenzaldehyde, nitriles/anilines and a nucleophile (N,N-disubstituted anilines) for the synthesis of a range of functionalized N-substituted isoindolinone derivatives is described. This metal-free intramolecular cyclization reaction furnishes the desired products in good to excellent yields. The process is environmentally friendly and offers a sustainable method for synthesizing a diverse library of N-substituted isoindolinone derivatives under acidic conditions. This cascade reaction triggers the formation of a C–C and two C–N bonds involving carbonyl and carboxyl groups in the presence of nitriles/anilines. Additionally, in the absence of a nitrogen source, 3-substituted isobenzofuran-1(3H)-ones are synthesized.
The Promise of Artificial Intelligence in Neuroanesthesia: An Update
Authors: Liao Zhenrui , Mathur Niharika , Joshi Vidur , Joshi Shailendra 
Published: August 2024

AbstractArtificial intelligence (AI) is poised to transform health care across medical specialties. Although the application of AI to neuroanesthesiology is just emerging, it will undoubtedly affect neuroanesthesiologists in foreseeable and unforeseeable ways, with potential roles in preoperative patient assessment, airway assessment, predicting intraoperative complications, and monitoring and interpreting vital signs. It will advance the diagnosis and treatment of neurological diseases due to improved risk identification, data integration, early diagnosis, image analysis, and pharmacological and surgical robotic assistance. Beyond direct medical care, AI could also automate many routine administrative tasks in health care, assist with teaching and training, and profoundly impact neuroscience research. This article introduces AI and its various approaches from a neuroanesthesiology perspective. A basic understanding of the computational underpinnings, advantages, limitations, and ethical implications is necessary for using AI tools in clinical practice and research. The update summarizes recent reports of AI applications relevant to neuroanesthesiology. Providing a holistic view of AI applications, this review shows how AI could usher in a new era in the specialty, significantly improving patient care and advancing neuroanesthesiology research.
Developing a BOPPPS (Bridge-in, Objectives, Pre-assessment, Participatory Learning, Post-assessment and Summary) model combined with the OBE (Outcome Based Education) concept to improve the teaching outcomes of higher education
Authors: Xu Zhiwei , Ge Liping , He Wei , Song Guiqin , Liu Jie , Hou Lijuan , Zhang Xiaoyun , Chang Xiaotong , Yin Lan , Li Xiaoming 
Published: August 2024

AbstractThe teaching objectives of traditional approaches in higher education emphasize mostly students’ mastery of knowledge and have insufficient directionality to social needs. In this study, we developed a BOPPPS (Bridge-in, Objectives, Pre-assessment, Participatory Learning, Post-assessment and Summary) teaching model combined with the OBE (Outcome Based Education) concept to enhance the teaching outcomes. Firstly, based on the graduation requirements and professional training objectives of students, we divided the course objectives into three dimensions (knowledge, ability and quality), and further specified into index points. Then, the teaching content of each chapter was set to correspond with the index points. Finally, the BOPPPS teaching model was used to meet each requirement. Clinical biochemistry testing course was used as a model to assess the effects of the teaching reform. After the class, the teaching effect was analyzed based on the questionnaire surveys from the students and their scores of both the chapter and final examinations. The results showed that compared with the traditional approach, the BOPPPS teaching model combined with the OBE concept has demonstrated a notable enhancement in student engagement, and significant improvement of their mastery of knowledge, application skills, and problem-solving abilities. The examination scores of the BOPPPS group were markedly higher than those of the traditional group. Moreover, the difference between the two groups diverse assessment scores was much bigger than that between the two group examination scores. Our study indicates that the BOPPPS teaching model combined with the OBE concept is a highly effective teaching model for enhancing the learning effectiveness of students.
Phase velocity shifts of shear surface waves in flexoelectric wave-guide clamped on piezomagnetic base
Authors: Biswas Mahargha , Sahu Sanjeev A 
Published: August 2024

Abstract
Surface acoustic wave devices featuring periodic layers of piezomagnetic and piezoelectric-flexoelectric layers are subject to intense investigation. In miniaturized devices, large strain gradients are possible that produce significant flexoelectric fields in piezoelectric components. In the present theoretical research, surface acoustic wave transference has been manifested in a flexoelectric waveguide clamped over a piezomagnetic base. This endeavor involves the formulation and solution of coupled magneto-electro-elastic field equations governing the structure’s behavior. Coupled magneto-electro-elastic field equations for the structure have been derived and solved utilizing analytical techniques. By accounting for pertinent boundary conditions, the dispersion relations characterizing the velocity of surface waves, both in scenarios with and without electrodes have been obtained. Based on proper numerical examples, the frequency and phase velocity spectrum have been plotted offering insights into key parameters i.e. modal frequency, phase velocity, and wave attenuation. The outcomes of the theoretical study may be helpful in providing insights into mechanical wave propagation in coupled piezoelectric/piezomagnetic structures.
Photoelectron momentum distributions of triatomic CO2 molecules by circularly polarized attosecond pulses
Authors: Zhang 张 Si-Qi 思琪 , Zhang 张 Jun 军 , Hao 郝 Xin-Yu 欣宇 , Guo 郭 Jing 静 , Liu 刘 Aihua 爱华 , Liu 刘 Xue-Shen 学深 
Published: August 2024

Abstract
Molecular-frame photoelectron momentum distributions (MF-PMDs) have been studied for imaging molecular structures. We investigate the MF-PMDs of CO2 molecules exposed to circularly polarized (CP) attosecond laser pulses by solving the time-dependent Schrödinger equations based on the single-active-electron approximation frames. Results show that high-frequency photons lead to photoelectron diffraction patterns, indicating molecular orbitals. These diffraction patterns can be illustrated by the ultrafast photoionization models. However, for the driving pulses with 30 nm, a deviation between MF-PMDs and theoretically predicted results of the ultrafast photoionization models is produced because the Coulomb effect strongly influences the molecular photoionization. Meanwhile, the MF-PMDs rotate in the same direction as the helicity of driving laser pulses. Our results also demonstrate that the MF-PMDs in a CP laser pulse are the superposition of those in the parallel and perpendicular linearly polarized cases. The simulations efficiently visualize molecular orbital geometries and structures by ultrafast photoelectron imaging. Furthermore, we determine the contribution of HOMO and HOMO-1 orbitals to ionization by varying the relative phase and the ratio of these two orbitals.
Effective regulation of the interaction process among three optical solitons
Authors: Yi 伊 Houhui 厚会 , Li 李 Xiaofeng 晓凤 , Zhang 张 Junling 俊玲 , Zhang 张 Xin 鑫 , Ma 马 Guoli 国利 
Published: August 2024

Abstract
The interaction between three optical solitons is a complex and valuable research direction, which is of practical application for promoting the development of optical communication and all-optical information processing technology. In this paper, we start from the study of the variable-coefficient coupled higher-order nonlinear Schrödinger equation (VCHNLSE), and obtain an analytical three-soliton solution of this equation. Based on the obtained solution, the interaction of the three optical solitons is explored when they are incident from different initial velocities and phases. When the higher-order dispersion and nonlinear functions are sinusoidal, hyperbolic secant, and hyperbolic tangent functions, the transmission properties of three optical solitons before and after interactions are discussed. Besides, this paper achieves effective regulation of amplitude and velocity of optical solitons as well as of the local state of interaction process, and interaction-free transmission of the three optical solitons is obtained with a small spacing. The relevant conclusions of the paper are of great significance in promoting the development of high-speed and large-capacity optical communication, optical signal processing, and optical computing.
The Energy Sources and the Explosion Mechanism of Ca-rich Supernova PTF 10iuv
Authors: Huang 黄 Qiu-Ping 秋萍 , Wang 王 Shan-Qin 善钦 , Wang 王 Tao 涛 , Gan 甘 Wen-Pei 文沛 , Shi 石 Deng-Wang 登旺 , Wang 王 Liu-Yi 浏毅 , Liang 梁 En-Wei 恩维 
Published: August 2024

Abstract
In this paper, we perform the detailed modeling for the light curves (LCs) of PTF 10iuv which is a calcium-rich (Ca-rich) supernova (SN) to constrain the physical properties of its ejecta and the energy sources, as well as the explosion mechanism. We find that the 56Ni model and the 56Ni plus circumstellar interaction model fail to explain the LCs, while the four-element (56Ni, 48Cr, 52Fe, and 44Ti) model can account for the LCs. The ejecta mass of PTF 10iuv derived by the model (

1.52

−
0.25

+
0.34

M
⊙) is consistent with that of the merger of a sub-Chandrasekhar mass white dwarf. The early-time LCs were mainly powered by 56Ni whose mass is ∼0.03 M
⊙, while the contributions of 48Cr and 52Fe can be neglected. The derived 44Ti mass (∼0.25 M
⊙) is ∼1.8 times the upper limit of the derived 44Ti mass of Ca-rich SN 2005E. We suggest that subtracting the contributions of the host-galaxy, which are unknown, and including the flux from other long-lived elements (e.g., 57Co, 55Fe, 60Co) can reduce the amount of 44Ti, and that this value can be regarded as an upper limit.
Fractional diffusion equations interpolate between damping and waves
Authors: Manapany Andy , Fumeron Sébastien , Henkel Malte 
Published: August 2024

Abstract
The behaviour of the solutions of the time-fractional diffusion equation, based on the Caputo derivative, is studied and its dependence on the fractional exponent is analysed. The time-fractional convection–diffusion equation is also solved and an application to Pennes bioheat model is presented. Generically, a wave-like transport at short times passes over to a diffusion-like behaviour at later times.
A Plastic Kavi?
Authors: Ghosh Ranjan 
Published: August 2024

Abstract
This chapter conceptualizes the radical idea of ‘plastic kavi’ in relation to Tagore and his thoughts. A plastic kavi exists in the singularities of plastic moments where the flashpoints in thinking and formation are explosions that construct forms, develop their points of ignition from forms that are difficult to destroy, and initiate differentiations in critical thinking and aesthetic-ethical experiences. The chapter taps into the possibilities of Tagore to be other than what he is considered to be and what he thought he possibly could be. Plastic Tagore is the love for a Tagore who has always been restive, tensional, withdrawn, and recluse—a creative surplus that meant more but communicated less, achieved less in meaning but produced possibilities of agonistic life worlds.
The Plastizität of Visva Sāhitya
Authors: Ghosh Ranjan 
Published: August 2024

Abstract
This chapter gives a completely new reading of Tagore’s idea of the world of literature, world literature, and the principle of the comparative. Ghosh introduces his ideas of plasticity and plastic theory to open up a fresh area of intervention in Tagore’s engagement with comparative/world literature. Also, plasticity questions the local and the global bind in literary understanding and the chapter argues for an understanding that extends Tagorean thinking in this area and gives it a new meaning. The chapter argues how visva sāhitya becomes plastic sahitya in the sense of littérature-monde, as being a high entropy event and having its own immanence. The plasticization of world literature creates corresponding worlds in visva of sahitya and visva sahitya. The chapter also exemplifies Ghosh’s exposition of trans-worlding.
Adipose stem cell-derived exosomes in the treatment of wound healing in preclinical animal models: a meta-analysis
Authors: Wei Jing-tao , He Ting , Shen Kuo , Xu Zhi-gang , Han Jun-tao , Yang Xue-kang 
Published: August 2024

Abstract

Background
Wound healing has always been a serious issue for doctors and primary health care systems. In addition, adipose stem cell-derived exosomes have been proven to play a positive and effective role in tissue repair and regeneration. A systematic review of these preclinical studies was performed to assess the efficacy of adipose stem cell-derived exosomes (ADSC-Exos) in treating wounds. This article aimed to study the effectiveness of ADSC-Exos for the treatment of animal skin wounds and includes a meta-analysis of exosomes from general wounds and diabetic ulcer wounds in in vitro models of animals to provide a theoretical basis for clinical translation.

Methods
A total of 19 studies with 356 animals were identified by searching the PubMed, Cochrane, MEDLINE Complete, Web of Science, CNKI and Wanfang databases from inception to 15 November 2022. No language or time restrictions were applied. Stata17 was used for all the data analyses.

Results
The meta-analysis showed that ADSC-Exo therapy significantly improved the wound healing rate in the control group, except in the diabetes group on day 7. Day 7 of general wounds [standard mean difference (SMD) 2.87, 95% confidence interval (CI) 1.91–3.83)] and day 14 (SMD 2.89, 95%CI 1.47–4.30). Day 14 (SMD 3.43, 95%CI 1.28–5.58) of diabetic wounds. Other outcomes, such as blood vessel density, collagen deposition and wound re-epithelization, improved with the administration of ADSC-Exos.

Conclusions
A meta-analysis showed that ADSC-Exo therapy applied to general and diabetic wounds can promote neovascularization, improve epithelization and collagen fiber deposition, promote healing, and reduce scar formation. ADSC-Exos have broad potential in preclinical research and clinical fields.
Patient-Related Factors Associated With Long-Term Outcomes After Successful Endoscopic Balloon Dilation For Crohn’s Disease-Associated Ileo-Colic Strictures: A Systematic Review and Meta-analysis
Authors: Menezes Nascimento Filho Hiram , Kum Angelo So Taa , Bestetti Alexandre Moraes , da Silva Pedro Henrique Veras Ayres , Gallegos Megui Marilia Mansilla , Damião Adérson Omar Mourão Cintra , Navaneethan Udayakumar , de Moura Eduardo Guimarães Hourneaux 
Published: August 2024

Abstract

Background
Successful Crohn’s disease (CD) therapy relies on timely and precise management strategies. Endoscopic balloon dilation (EBD) has been applied as a first-line treatment for symptomatic CD-associated strictures due to its minimally invasive nature and the possibility of preserving intestinal length.

Objective
The aim of the present study was to determine patient-related predictive factors associated with the need for surgery for CD-associated ileocolic strictures after technically successful EBD.

Methods
All original studies published before December 2023 that reported the outcomes of patients treated with EBD for ileocolic strictures secondary to CD and described follow-up for at least 1 year were included. The difference in risk of needing surgery was calculated for 8 different patient characteristics (Sex, smoking habit, previous surgery, biologic therapy, steroids, immunosuppressors, nature of the stricture, and endoscopic disease activity).

Results
There were significant differences in the risk of needing surgery after EBD among patients who underwent surgery and patients without a history of surgery (RD: −0.20 [−0.31, −0.08]), patients with endoscopic mucosal activity and patients in remission at the time of EBD (RD: 0.19 [0.04, 0.34]), patients using biologics at the time of EBD and patients not using biologics (RD: −0.09 [−0.16, −0.03]), and patients using steroids and those not using steroids at the time of EBD (RD: 0.16 [0.07, 0.26]).

Conclusions
The use of biologics and endoscopic disease remission at the time of EBD were protective factors against the need for surgery. No previous surgery or use of steroids at the time of EBD was associated with the need for surgery during follow-up.
Girk3 deletion increases osteoblast maturation and bone mass accrual in adult male mice
Authors: Weaver Samantha R , Torres Haydee M , Arnold Katherine M , Zars Elizabeth L , Peralta-Herrera Eduardo , Taylor Earnest L , Yu Kanglun , Marron Fernandez de Velasco Ezequiel , Wickman Kevin , McGee-Lawrence Meghan E , Bradley Elizabeth W , Westendorf Jennifer J 
Published: August 2024

Abstract
Osteoporosis and other metabolic bone diseases are prevalent in the aging population. While bone has the capacity to regenerate throughout life, bone formation rates decline with age and contribute to reduced bone density and strength. Identifying mechanisms and pathways that increase bone accrual in adults could prevent fractures and accelerate healing. G protein-gated inwardly rectifying K+ (GIRK) channels are key effectors of G protein-coupled receptor signaling. Girk3 was recently shown to regulate endochondral ossification. Here, we demonstrate that deletion of Girk3 increases bone mass after 18 weeks of age. Male 24-week-old Girk3-/- mice have greater trabecular bone mineral density and bone volume fraction than wildtype (WT) mice. Osteoblast activity is moderately increased in 24-week-old Girk3-/- mice compared to WT mice. In vitro, Girk3-/- bone marrow stromal cells (BMSCs) are more proliferative than WT BMSCs. Calvarial osteoblasts and BMSCs from Girk3-/- mice are also more osteogenic than WT cells, with altered expression of genes that regulate the wingless-related integration site (Wnt) family. Wnt inhibition via Dickkopf-1 (Dkk1) or β-catenin inhibition via XAV939 prevents enhanced mineralization, but not proliferation, in Girk3-/- BMSCs and slows these processes in WT cells. Finally, selective ablation of Girk3 from cells expressing Cre recombinase from the 2.3 kb-Col1a1 promoter, including osteoblasts and osteocytes, is sufficient to increase bone mass and bone strength in male mice at 24 weeks of age. Taken together, these data demonstrate that Girk3 regulates progenitor cell proliferation, osteoblast differentiation, and bone mass accrual in adult male mice.
Autonomy and critique in the goal-oriented university: the paradox of teaching reflexivity
Authors: Berglund Leo 
Published: August 2024

Abstract
This article explores the meaning of the task of teaching students to formulate critique in relation to the so-called ‘pedagogical paradox’, according to which the educational ideal of individual autonomy is contradicted by the practice of planning and control, which is particularly pronounced in the influential model of ‘constructive alignment’. Taking Kant’s idea of enlightenment and autonomy as a starting point, I introduce Luc Boltanski’s concept of reflexivity and link it to Jon Elster’s discussion of ‘states that are essentially by-products’. In doing so, I advance the view that genuine critique typically emerges from a shift in perspective, from the pragmatic realization of goals according to institutionalized practices to a metapragmatic reflection on those practices. Since teaching is itself an institutionalized practice, personal reflexivity can only be understood as a by-product of teaching, and, contra the logic of models like constructive alignment, it cannot be set as a direct objective. Emerging from the subject itself, rather than from the influence of an educational technique, personal reflexivity should be recognized as an important aspect of the subject’s transition from youth to maturity.
Sexual function, health functionality, and quality of life in females with pulmonary arterial hypertension: a cross-sectional study
Authors: Oliveira Leticia Fernanda Tavares Sousa , Arakaki Jaquelina Sonoe Ota , Vieira Elaine Brito , Lopes Juliana de Lima , Lopes Camila Takao , Abuchaim Erika da Silva , Santos Vinicius Batista 
Published: August 2024

Abstract

Background
Pulmonary arterial hypertension (PAH) can have several consequences on sexual function, which can lead to worsened quality of life.

Aim
The study sought to assess sexual function and its association with health functionality and quality of life in females with PAH.

Methods
A descriptive cross-sectional study was carried out in pulmonary circulation outpatient clinics from January 2022 to March 2023 in females diagnosed with pulmonary hypertension. Assessment was carried out through the application of the Female Sexual Function Index, the 36-item World Health Organization Disability Assessment Schedule, and the Medical Outcome Study 36-Item Short Form Survey.

Outcomes
Data were analyzed using SPSS version 22.0 and JASP, and Spearman’s correlation tests were applied between the instruments, with a P value &lt;.05 considered significant.

Results
A total of 91 females were assessed. It was identified that 90.1% of females had sexual dysfunction, with worse scores in females with sexual dysfunction in the domains of satisfaction, arousal, and desire, with average health functionality and quality of life. There were significant correlations between the domains of mobility, getting along, life activities, and the overall functionality score with some domains of sexual function, especially arousal and satisfaction. We found significant correlations between some domains of quality-of-life assessment with the domains of desire, arousal, and satisfaction, and with the overall score of sexual function assessment, as well as strong correlations between health functionality and quality of life.

Clinical Implication
The data reinforce the need for rehabilitation programs and social support for this population.

Strengths and Limitations
This is one of the few studies to evaluate sexual function, quality of life, and health functionality in women with PAH. Due to limitations in data collection, we were unable to assess certain factors such as hormone levels and a history of sexual abuse.

Conclusion
We identified a high prevalence of sexual dysfunction in females with PAH with mild functional impairment and a moderate quality-of-life score with correlations between sexual function, health functionality, and quality of life.