bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: NbCl5 Mediated Biomimetic Cascade Reaction: Efficient and Scalable One‐Pot Synthesis of Dunnione and Nor‐β‐lapachone.
Authors: Bian Jinlei , Qian Xue , Fan Jun , Li Xiang , Sun Haopeng , You Qidong , Zhang Xiaojin 
Published: May 2015

AbstractThis NbCl5‐mediated one‐pot reaction gives access to the bioactive natural products dunnione (II) and nor‐β‐lapachone (IV) via tandem Claisen rearrangement‐cyclization reaction.
ChemInform Abstract: Dinitrosyl Iron Complexes (DNICs): From Biomimetic Synthesis and Spectroscopic Characterization Toward Unveiling the Biological and Catalytic Roles of DNICs
Authors: Tsai Ming‐Li , Tsou Chih‐Chin , Liaw Wen‐Feng 
Published: May 2015

AbstractReview: 57 refs.
ChemInform Abstract: In vitro Antibacterial Activity of Few Novel 2‐(Heteroarylamino)‐5‐(aryl)‐1,3,4‐thiadiazoles
Authors: Vadivelu Annapoorna , Gopal V. , Reddy C. Uma Maheswara , Evanjelene Vasthi Kennedy 
Published: May 2015

AbstractReview: 12 refs.
ChemInform Abstract: Solid‐State Protein‐Carbohydrate Interactions and Their Application in the Food Industry
Authors: Soltanizadeh Nafiseh , Mirmoghtadaie Leila , Nejati Fatemeh , Najafabadi Leila Izadi , Heshmati Maryam Khakbaz , Jafari Maryam 
Published: May 2015

AbstractReview: 99 refs.
Biocatalytic Approach for the Synthesis of Enantiopure Acebutolol as a β1‐Selective Blocker
Authors: Banoth Linga , Thakur Neeraj Singh , Bhaumik Jayeeta , Banerjee Uttam Chand 
Published: May 2015

AbstractA new chemoenzymatic route is reported to synthesize acebutolol, a selective β1 adrenergic receptor blocking agent in enantiopure (R and S) forms. The enzymatic kinetic resolution strategy was used to synthesize enantiopure intermediates (R)‐ and (S)‐N‐(3‐acetyl‐4‐(3‐chloro‐2‐hydroxypropoxy)phenyl)butyramide from the corresponding racemic alcohols. The results showed that out of eleven commercially available lipase preparations, two enzyme preparations (Lipase A, Candida antarctica, CLEA [CAL CLEA] and Candida rugosa lipase, 62316 [CRL 62316]) act in enantioselective manner. Under optimized conditions the enantiomeric excess of both (R)‐ and (S)‐N‐(3‐acetyl‐4‐(3‐chloro‐2‐hydroxypropoxy)phenyl)butyramide were 99.9 and 96.8%, respectively. N‐alkylation of both the (R) and (S) intermediates with isopropylamine gave enantiomerically pure (R and S)‐ acebutolol with a yield 68 and 72%, respectively. This study suggests a high yielding, easy and environmentally green approach to synthesize enantiopure acebutolol. Chirality 27:382–391, 2015. © 2015 Wiley Periodicals, Inc.
Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism
Authors: Huang Huang , Si Pei , Wang Lei , Xu Yong , Xu Xin , Zhu Jin , Jiang Hualiang , Li Weihua , Chen Lili , Li Jian 
Published: May 2015

AbstractFarnesoid X receptor (FXR) plays an important role in the regulation of cholesterol, lipid, and glucose metabolism. Recently, several studies on the molecular basis of FXR antagonism have been reported. However, none of these studies employs an FXR antagonist with nonsteroidal scaffold. On the basis of our previously reported FXR antagonist with a trisubstituted isoxazole scaffold, a novel nonsteroidal FXR ligand was designed and used as a lead for structural modification. In total, 39 new trisubstituted isoxazole derivatives were designed and synthesized, which led to pharmacological profiles ranging from agonist to antagonist toward FXR. Notably, compound 5s (4′‐[(3‐{[3‐(2‐chlorophenyl)‐5‐(2‐thienyl)isoxazol‐4‐yl]methoxy}‐1H‐pyrazol‐1‐yl)methyl]biphenyl‐2‐carboxylic acid), containing a thienyl‐substituted isoxazole ring, displayed the best antagonistic activity against FXR with good cellular potency (IC50=12.2±0.2 μM). Eventually, this compound was used as a probe in a molecular dynamics simulation assay. Our results allowed us to propose an essential molecular basis for FXR antagonism, which is consistent with a previously reported antagonistic mechanism; furthermore, E467 on H12 was found to be a hot‐spot residue and may be important for the future design of nonsteroidal antagonists of FXR.
Survival benefit of levetiracetam in patients treated with concomitant chemoradiotherapy and adjuvant chemotherapy with temozolomide for glioblastoma multiforme
Authors: Kim Young‐Hoon , Kim Tackeun , Joo Jin‐Deok , Han Jung Ho , Kim Yu Jung , Kim In Ah , Yun Chang‐Ho , Kim Chae‐Yong 
Published: May 2015

BACKGROUNDA chemosensitizing effect of levetiracetam (LEV) has been suggested because LEV inhibits O‐6 methylguanine‐DNA methyltransferase (MGMT). However, the survival benefit of LEV has not been clinically documented. The objective of this study was to assess the survival benefit of LEV compared with other antiepileptic drugs as a chemosensitizer to temozolomide for patients with glioblastoma.METHODSIn total, 103 consecutive patients with primary glioblastoma who received concomitant chemoradiotherapy and adjuvant chemotherapy with temozolomide were retrospectively reviewed, and 58 patients (56%) received LEV during temozolomide chemotherapy for at least 3 months. A Cox regression survival analysis was performed to adjust for confounding factors, including age, extent of lesion, Karnofsky performance scale score, extent of removal, and MGMT promoter methylation status.RESULTSThe median progression‐free survival (PFS) and overall survival (OS) for patients who received LEV in combination with temozolomide (PFS: median, 9.4 months; 95% confidence interval [CI], 7.5‐11.3 months; OS: median, 25.7 months; 95% CI, 21.7‐29.7 months) were significantly longer than those for patients who did not receive LEV (PFS: median, 6.7 months; 95% CI, 5.8‐7.6 months; OS: median, 16.7 months; 95% CI, 12.1‐21.3 months; P = .010 and P = .027, respectively). In multivariate analysis, the variables that were identified as significant prognostic factors for OS were preoperative Karnofsky performance scale score (hazard ratio [HR], 0.37; P = .016), MGMT promoter methylation (HR, 0.30; P = .002), and receipt of LEV (HR, 0.31; P < .001.CONCLUSIONSLEV may provide a survival benefit in patients with glioblastoma who receive temozolomide‐based chemotherapy. A prospective randomized study may be indicated. Cancer 2015;121:2926–2932. © 2015 American Cancer Society.
Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice
Authors: Andrews William D. , Davidson Kathryn , Tamamaki Nobuaki , Ruhrberg Christiana , Parnavelas John G. 
Published: May 2015

ABSTRACTCortical interneurons are generated predominantly in the medial ganglionic eminence (MGE) and migrate through the ventral and dorsal telencephalon before taking their final positions within the developing cortical plate. Previously we demonstrated that interneurons from Robo1 knockout (Robo1−/−) mice contain reduced levels of neuropilin 1 (Nrp1) and PlexinA1 receptors, rendering them less responsive to the chemorepulsive actions of semaphorin ligands expressed in the striatum and affecting their course of migration (Hernandez‐Miranda et al. [2011] J. Neurosci. 31:6174–6187). Earlier studies have highlighted the importance of Nrp1 and Nrp2 in interneuron migration, and here we assess the role of PlexinA1 in this process. We observed significantly fewer cells expressing the interneuron markersGad67andLhx6in the cortex ofPlexinA1−/−mice compared with wild‐type littermates at E14.5 and E18.5. Although the level of apoptosis was similar in the mutant and control forebrain, proliferation was significantly reduced in the former. Furthermore, progenitor cells in the MGE ofPlexinA1−/−mice appeared to be poorly anchored to the ventricular surface and showed reduced adhesive properties, which may account for the observed reduction in proliferation. Together our data uncover a novel role for PlexinA1 in forebrain development. J. Comp. Neurol. 524:518–534, 2016. © 2015 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development
Authors: Pirson Marc , Knoops Bernard 
Published: May 2015

ABSTRACTReactive oxygen and nitrogen species (ROS/RNS) are natural byproducts of cellular metabolism. Although these molecules are deleterious at high concentrations, moderate levels of ROS/RNS are essential for normal cell function and take part in numerous cellular processes. The regulation of ROS/RNS is largely attended by peroxiredoxins (Prdxs) and their main reductants, thioredoxins (Trxs). Through their oxidoreductase activities, the members of the Trx/Prdx system can also affect certain cellular processes, notably many implicated in central nervous system (CNS) development. Although several studies have investigated the expression of Prdxs and Trxs in mouse, rat, and human adult CNS, few data are available concerning embryonic stages. In this work, we use immunofluorescence analyses to study the distribution of these enzymes during prenatal mouse spinal cord development. Our results highlight several patterns that contrast with available data for the adult. Indeed, Prdx1, Prdx4, and Prdx6, which are expressed in glial cells in the adult CNS, present clear neuronal localization in mouse spinal cord during embryonic development. Additionally, Prdx1, Prdx2, and to a lesser extent Prdx4, Prdx6, and Trx1 are localized mainly in the nucleus of neural cells. Finally, we identified a consistent, intense expression of all Prdxs and Trxs in groups of cells located in ventral regions of the spinal cord that express motor neuronal markers. These striking expression patterns suggest novel functions of these enzymes at these stages and offer clues to the role of the Trx/Prdx system during embryonic development of the spinal cord. J. Comp. Neurol. 523:2599–2617, 2015. © 2015 Wiley Periodicals, Inc.
Low‐latency Java communication devices on RDMA‐enabled networks
Authors: Expósito Roberto R. , Taboada Guillermo L. , Ramos Sabela , Touriño Juan , Doallo Ramón 
Published: May 2015

SummaryProviding high‐performance inter‐node communication is a key capability for running high performance computing applications efficiently on parallel architectures. In fact, current systems deployments are aggregating a significant number of cores interconnected via advanced networking hardware with Remote Direct Memory Access (RDMA) mechanisms, that enable zero‐copy and kernel‐bypass features. The use of Java for parallel programming is becoming more promising thanks to some useful characteristics of this language, particularly its built‐in multithreading support, portability, easy‐to‐learn properties, and high productivity, along with the continuous increase in the performance of the Java virtual machine. However, current parallel Java applications generally suffer from inefficient communication middleware, mainly based on protocols with high communication overhead that do not take full advantage of RDMA‐enabled networks. This paper presents efficient low‐level Java communication devices that overcome these constraints by fully exploiting the underlying RDMA hardware, providing low‐latency and high‐bandwidth communications for parallel Java applications. The performance evaluation conducted on representative RDMA networks and parallel systems has shown significant point‐to‐point performance increases compared with previous Java communication middleware, allowing to obtain up to 40% improvement in application‐level performance on 4096 cores of a Cray XE6 supercomputer. Copyright © 2015 John Wiley & Sons, Ltd.
Assembly of Mesoporous Metal–Organic Framework Templated by an Ionic Liquid/Ethylene Glycol Interface
Authors: Sang Xinxin , Zhang Jianling , Peng Li , Liu Chengcheng , Ma Xue , Han Buxing , Yang Guanying 
Published: May 2015

AbstractWe propose a facile room‐temperature synthesis of a metal–organic framework (MOF) with a bimodal mesoporous structure (3.9 and 17‐28 nm) in an ionic liquid (IL)/ethylene glycol (EG) mixture. The X‐ray diffraction analysis reveals that MOF formation can be efficiently promoted by the presence of the EG/IL interface at room temperature. The MOFs with mesoporous networks are characterized by SEM and TEM. The formation mechanism of the mesoporous MOF in EG/IL mixture is investigated. It is proposed that the EG nanodroplets in the IL work as templates for the formation of the large mesopores. The as‐synthesized mesoporous metal–organic framework is an effective and reusable heterogeneous catalyst to catalyze the aerobic oxidation of benzylic alcohols.
Effects of prenatal stress and emotional reactivity of the mother on emotional and cognitive abilities in lambs
Authors: Coulon Marjorie , Nowak Raymond , Andanson Stephane , Petit Bérengère , Lévy Frédéric , Boissy Alain 
Published: May 2015

ABSTRACTConsequences of prenatal stress on emotional reactivity and cognitive abilities in offspring are under‐documented in precocial mammals. Here, we investigated to what extent emotional reactivity, judgment bias and spatial learning abilities of lambs are affected by chronic stress during late pregnancy and by their dams' emotional reactivity. The 20 highest‐responsive (HR) and 20 lowest‐responsive (LR) ewes from a population of 120 Romane ewes were selected according to their pre‐mating reactivity to social isolation in a new environment. Over the final third of pregnancy, 10 HR ewes and 10 LR ewes were exposed daily to various unpredictable aversive events such as restraint, mixing groups and transport while the other 20 selected ewes were not. In a human and an object test, prenatally‐stressed lambs were more fearful than control lambs, but the prenatal stress effect was moderated by the reactivity of the mothers: prenatally‐stressed lambs from ewes with high emotional reactivity were more affected. Prenatally‐stressed lambs did not perform as well as control lambs in a maze test and showed pessimistic‐like judgment in a cognitive bias test. Prenatally‐stressed lambs were thus characterized by a negative affective state with increased fear reactions and impaired cognitive evaluation. The development of negative moods could have long‐lasting consequences on the coping strategies of the lambs in response to their rearing conditions. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 57: 626–636, 2015.
Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway
Authors: Chang Jessica T. , Lehtinen Maria K. , Sive Hazel 
Published: May 2015

ABSTRACTCerebrospinal fluid (CSF) includes conserved factors whose function is largely unexplored. To assess the role of CSF during embryonic development, CSF was repeatedly drained from embryonic zebrafish brain ventricles soon after their inflation. Removal of CSF increased cell death in the diencephalon, indicating a survival function. Factors within the CSF are required for neuroepithelial cell survival as injected mouse CSF but not artificial CSF could prevent cell death after CSF depletion. Mass spectrometry analysis of the CSF identified retinol binding protein 4 (Rbp4), which transports retinol, the precursor to retinoic acid (RA). Consistent with a role for Rbp4 in cell survival, inhibition of Rbp4 or RA synthesis increased neuroepithelial cell death. Conversely, ventricle injection of exogenous human RBP4 plus retinol, or RA alone prevented cell death after CSF depletion. Zebrafish rbp4 is highly expressed in the yolk syncytial layer, suggesting Rbp4 protein and retinol/RA precursors can be transported into the CSF from the yolk. In accord with this suggestion, injection of human RBP4 protein into the yolk prevents neuroepithelial cell death in rbp4 loss‐of‐function embryos. Together, these data support the model that Rbp4 and RA precursors are present within the CSF and used for synthesis of RA, which promotes embryonic neuroepithelial survival. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 75–92, 2016
The Drosophila ortholog of the Zc3h14 RNA binding protein acts within neurons to pattern axon projection in the developing brain
Authors: Kelly Seth M. , Bienkowski Rick , Banerjee Ayan , Melicharek David J. , Brewer Zachariah A. , Marenda Daniel R. , Corbett Anita H. , Moberg Kenneth H. 
Published: May 2015

ABSTRACTThe dNab2 polyadenosine RNA binding protein is the D. melanogaster ortholog of the vertebrate ZC3H14 protein, which is lost in a form of inherited intellectual disability (ID). Human ZC3H14 can rescue D. melanogaster dNab2 mutant phenotypes when expressed in all neurons of the developing nervous system, suggesting that dNab2/ZC3H14 performs well‐conserved roles in neurons. However, the cellular and molecular requirements for dNab2/ZC3H14 in the developing nervous system have not been defined in any organism. Here we show that dNab2 is autonomously required within neurons to pattern axon projection from Kenyon neurons into the mushroom bodies, which are required for associative olfactory learning and memory in insects. Mushroom body axons lacking dNab2 project aberrantly across the brain midline and also show evidence of defective branching. Coupled with the prior finding that ZC3H14 is highly expressed in rodent hippocampal neurons, this requirement for dNab2 in mushroom body neurons suggests that dNab2/ZC3H14 has a conserved role in supporting axon projection and branching. Consistent with this idea, loss of dNab2 impairs short‐term memory in a courtship conditioning assay. Taken together these results reveal a cell‐autonomous requirement for the dNab2 RNA binding protein in mushroom body development and provide a window into potential neurodevelopmental functions of the human ZC3H14 protein. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 93–106, 2016
Monoclonal antibodies to HLA‐E bind epitopes carried by unfolded β2m‐free heavy chains
Authors: Tremante Elisa , Lo Monaco Elisa , Ingegnere Tiziano , Sampaoli Camilla , Fraioli Rocco , Giacomini Patrizio 
Published: May 2015

Since HLA‐E heavy chains accumulate free of their light β2‐microglobulin (β2m) subunit, raising mAbs to folded HLA‐E heterodimers has been difficult, and mAb characterization has been controversial. Herein, mAb W6/32 and 5 HLA‐E‐restricted mAbs (MEM‐E/02, MEM‐E/07, MEM‐E/08, DT9, and 3D12) were tested on denatured, acid‐treated, and natively folded (both β2m‐associated and β2m‐free) HLA‐E molecules. Four distinct conformations were detected, including unusual, partially folded (and yet β2m‐free) heavy chains reactive with mAb DT9. In contrast with previous studies, epitope mapping and substitution scan on thousands of overlapping peptides printed on microchips revealed that mAbs MEM‐E/02, MEM‐E/07, and MEM‐E/08 bind three distinct α1 and α2 domain epitopes. All three epitopes are linear since they span just 4–6 residues and are “hidden” in folded HLA‐E heterodimers. They contain at least one HLA‐E‐specific residue that cannot be replaced by single substitutions with polymorphic HLA‐A, HLA‐B, HLA‐C, HLA‐F, and HLA‐G residues. Finally, also the MEM‐E/02 and 3D12 epitopes are spatially distinct. In summary, HLA‐E‐specific residues are dominantly immunogenic, but only when heavy chains are locally unfolded. Consequently, the available mAbs fail to selectively bind conformed HLA‐E heterodimers, and HLA‐E expression may have been inaccurately assessed in some previous oncology, reproductive immunology, virology, and transplantation studies.
Zero‐Field Splitting in {MnIII3(μ3‐O)} Core Single‐Molecule Magnets Investigated by Inelastic Neutron Scattering and High‐Field Electron Paramagnetic Resonance Spectroscopy
Authors: Sigrist Marc , L. W. Tregenna‐Piggott Philip , S. Pedersen Kasper , A. Sørensen Mikkel , Barra Anne‐Laure , Hauser Jürg , Liu Shi‐Xia , Decurtins Silvio , Mutka Hannu , Bendix Jesper 
Published: May 2015

AbstractThe global zero‐field splitting (ZFS) parameters of three, ferromagnetically coupled, μ3‐κ3‐[XO4]– (X = Cl, Re) capped, manganese(III) oximate single‐molecule magnets, [Mn3O(R‐sao)3(2,4′‐bipyridine)3XO4] [X = Cl, R = Me, Et; X = Re, R = Me; Me‐sao = 2‐hydroxyphenylethanone oximate(2–)], with crystallographic trigonal symmetry were determined by use of inelastic neutron scattering and high‐field/high‐frequency electron paramagnetic resonance spectroscopy. ReO4– (O···O ca. 1.7 Å) is larger than ClO4– (O···O ca. 1.4 Å), which allows more parallel alignment of the local ZFS tensors. However, this chemical modification results in concomitant distortions in the equatorial ligand plane. Consistent parametrization of all spectroscopic data was achieved, and effective spin‐reversal barriers determined from alternating current susceptibility data were shown to be in good accordance with the energy barriers deduced from spectroscopy.
Vicinal Functionalization of N‐Alkoxyenamines: Tandem Umpolung Phenylation–Nucleophilic Addition Reaction Sequence
Authors: Sato Shohei , Takeda Norihiko , Miyoshi Tetsuya , Ueda Masafumi , Miyata Okiko 
Published: May 2015

AbstractThe vicinal functionalization of N‐alkoxyenamines, derived in situ from aldehydes and isoxazolidines, has been achieved with the formation of two new carbon–carbon bonds by utilizing an organo‐aluminum reagent and subsequent allylmagnesium bromide or tributyltin cyanide as external carbon‐centered nucleophiles. By changing the second carbon nucleophile, various amine derivatives were obtained in good yields.
Pilot‐scale evaluation of concentrated piperazine for CO2 capture at an Australian coal‐fired power station: duration experiments
Authors: Cousins Ashleigh , Nielsen Paul , Huang Sanger , Cottrell Aaron , Chen Eric , Rochelle Gary T , Feron Paul H M 
Published: May 2015

AbstractDuration operation was completed as the final stage of evaluating concentrated piperazine as a CO2 capture solvent at the Tarong pilot plant. For the duration tests, a single operating set‐point was maintained for an extended period of time. The purpose of the duration tests was to monitor the formation of degradation products and the robustness of the solvent. Two duration tests were conducted that differed only in the regeneration temperature used (125 or 155 °C). Four hundred twenty‐five hours of operation were achieved on the solvent with a regeneration temperature of 125 °C. This was followed by a further 421 h of operation with a regeneration temperature of 155 °C, giving a total operating time on the solvent of 1700 h by the end of the project. For the duration experiments, roughly 500 tonnes of flue gas was treated, and approximately 70 tonnes of CO2 captured. The heat stable salt (HSS) measured in highest concentration was formate, with the rate of formation increasing with regeneration temperature. The effect of pre‐treatment could be seen with sulfate concentration in the solvent increasing sharply when caustic supply to the pre‐treatment column was interrupted. Despite the formation of degradation products in the solvent regeneration energy requirements were not notably effected. For operation up to 1700 h on a real coal flue gas, no loss of plant performance was observed. © 2015 Society of Chemical Industry and John Wiley & Sons, Ltd