bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Youth-Perceived Barriers and Attitudes Towards the Clinical Use of Pharmacogenetic Testing to Optimise Antidepressant Pharmacotherapy
Authors: Roberts Bradley , Cooper Zahra , Landery Georgia , Stanley Susanne , Majda Bernadette T. , Khan  , Collins R. L. , Akkari P. Anthony , Hood Sean D. , Rodger Jennifer 
Published: August 2024

AbstractThe field of pharmacogenetics (PGx) is experiencing significant growth, with increasing evidence to support its application in psychiatric care, suggesting its potential to personalise treatment plans, optimise medication efficacy, and reduce adverse drug reactions. However, the perceived utility and practicability of PGx for psychiatric treatment in youth remains underexplored. This study investigated youth-perceived barriers and attitudes towards the implementation of PGx testing to guide antidepressant treatment in primary care. Semi-structured focus groups and interviews were conducted with 17 participants aged between 18 to 24 years. These sessions were recorded and transcribed before thematic analysis was used to identify collective themes. Three key themes were identified, including attitudes towards the medication prescription process, concerns and attitudes towards PGx testing, and perceived barriers to its clinical implementation. Although PGx testing was positively perceived by most participants, all participants shared concerns about PGx testing. Participants voiced concerns about the financial impact of PGx testing, the potential for treatment delays, and the accuracy of PGx testing in guiding antidepressant treatment. Additionally, participants noted that the low awareness and willingness of general practitioners to incorporate PGx testing into routine practice could hinder successful clinical implementation. Prior to the implementation of PGx testing into Australian primary practices, it is essential to acknowledge patient perspectives and ensure that clinical practices remain patient-focused. This study highlights important considerations for integrating PGx testing into antidepressant pharmacotherapy and emphasizes the need for future research to address and mitigate youth-perceived barriers.
Evaluating the clinical effectiveness and patient experience of an AI-based digital tool for home-based blood pressure management
Authors: Jelić Alan , Sesto Igor , Rotkvić Luka , Pavlović Luka , Erceg Nikola , Sesto Nina , Kraljevic Zeljko , Yeung Joshua Au , Folarin Amos , Dobson Richard , Laiou Petroula 
Published: August 2024

AbstractHypertension, a prevalent cardiovascular condition, requires effective management of multimodal health risk factors. This study examines the effectiveness of a digital health tool designed for hypertension management and explores user perspectives on its utility. We analyse a cohort of 5,136 participants who used the digital tool, which provides continuous blood pressure monitoring, real-time feedback, and personalized health recommendations. Our results show that users achieve significant reduction in their blood pressure values and this reduction is positively correlated with the duration for which users report their blood pressure values. Additionally, we obtain high retention rates even after one year of using the digital tool. User feedback was collected through an online survey revealing high satisfaction rates. Participants highlighted the tool’s ease of use, and felt less anxious. Overall, our study demonstrates the potential of digital health tools in enhancing hypertension management and highlights the importance of user-centred design in developing effective health interventions.
Diurnal rhythms in durum wheat triggered byRhopalosiphum padi(bird cherry-oat aphid)
Authors: Goldstein Yoshiahu , Han Jinlong , Kunk Daniel , Batushansky Albert , Nalam Vamsi , Tzin Vered 
Published: August 2024

AbstractWheat is a staple crop and one of the most widely consumed grains globally. Wheat yields can experience significant losses due to the damaging effects of herbivore infestation. However, little is known about the effect aphids have on the natural diurnal rhythms in plants. Our time-series transcriptomics and metabolomics study reveal intriguing molecular changes occurring in plant diurnal rhythmicity upon aphid infestation. Under control conditions, 15,366 out of the 66,559 genes in the tetraploid wheat cultivar Svevo, representing approximately 25% of the transcriptome, exhibited diurnal rhythmicity. Upon aphid infestation, 5,682 genes lost their rhythmicity, while additional 5,203 genes began to exhibit diurnal rhythmicity. The aphid-induced rhythmic genes were enriched in GO terms associated with plant defense, such as protein phosphorylation and cellular response to ABA and were enriched with motifs of the WRKY transcription factor families. Conversely, the genes that lost rhythmicity due to aphid infestation were enriched with motifs of the TCP and ERF transcription factor families. While the core circadian clock genes maintain their rhythmicity during infestation, we observed that approximately 60% of rhythmic genes experience disruptions in their rhythms during aphid infestation. These changes can influence both the plant’s growth and development processes as well as defense responses. Furthermore, analysis of rhythmic metabolite composition revealed that several monoterpenoids gained rhythmic activity under infestation, while saccharides retained their rhythmic patterns. Our findings highlight the ability of insect infestation to disrupt the natural diurnal cycles in plants, expanding our knowledge of the complex interactions between plants and insects.
Fibril Paint: a class of amyloid-targeting peptides
Authors: Pedrola Júlia Aragonès , Dekker Françoise A. , Guttmann Katrin , van Leeuwen Litske M. , Singh Shalini , Mayer Guy , Garfagnini Tommaso , Friedler Assaf , Rüdiger Stefan G. D. 
Published: August 2024

AbstractNeurodegenerative diseases, such as Alzheimer’s Disease, Parkinson’s Disease and Huntington’s Disease, are characterised by accumulation of amyloid fibrils, which remain incurable. It is of great importance to develop early-diagnosis approaches as well as disease-modifying therapies. Recently, we discovered the FibrilPaint1 peptide, a specific amyloid binder that can serve for fibril diagnosis. Here we introduce a class of FibrilPaint1 derivatives that bind to protein fibrils. The modifications include variation of the charge, termini and order of residues. As a result, we generated a class of peptides with general fibril-binding properties and with the potential for further adaptation, such as linkage to multiple dyes, optimisation for specific protein and aggregate strains, or adaptation for targeted protein degradation strategies. Thus, Fibril Paint peptides are a class of promising leads for targeting amyloid fibrils for diagnostic and therapeutic purposes.
Gynaecological health patterns and motherhood experiences of female professional football players
Authors: Ramagole Dimakatso , Rensburg Dina C Janse van , Cowie Charlotte , Mehta Ritan , Ramkilawon Gopika , Pluim Babette M. , Kerkhoffs Gino , Gouttebarge Vincent 
Published: August 2024

AbstractAimsTo explore health patterns in female professional football players in the domains of gynaecological health patterns, contraceptive use, body perception and motherhood experiences, including return to play after childbirth.MethodsAn online questionnaire was emailed to active female professional football players via email. Participants were asked about their menstrual cycle,contraception use and motherhood. Validated questionnaires were used to assess body dissatisfaction (BD) and drive for thinness (DT).ResultsA total of 74 female professional football players were enrolled. The mean age at menarche was 13.5 years, average cycle length of 26 days and a bleeding period of 5 days. Cycle irregularities were experienced by 30% of participants, and menstrual symptoms by 74%. Half of the participants used contraceptives, with 60% using hormonal contraceptives, primarily oral contraceptive pills (38%), followed by implants (20%). Participants had a normal BD score, but a higher-than-expected DT score. The motherhood rate was low (1%), with normal conception, vaginal delivery, return to training after 6 weeks, and return to competition after 12 weeks.ConclusionCycle irregularities are common in female professional football players, with a significant number of cycle-related symptoms. The majority on contraceptives preferred hormonal contraceptives, especially oral contraceptive pills (OCP) followed by implants, reflecting trends seen in elite athletes gynaecological health. While body satisfaction scores were normal, there was an unexpectedly high drive-for-thinness score, similar to that observed in lean or weight-category sports. The rate of motherhood was low, consistent with previous findings in professional football players.What is already known on this topicElite female athletes have unique challenges related to their menstrual cycle and symptoms.Elite athletes use mostly hormonal contraceptives, predominantly the OCP.They often have to choose between professional sports and motherhood.What this study addsOur findings show some similarities to other to other elite female athletes:30% have menstrual irregularities.74% have negative menstrual symptoms.Motherhood is low.Our participants have a high drive for thinness.How this study might affect research, practice or policyThis descriptive study is a basis for more prospective and epidemiological research in this cohort that has been established.More research will be stimulated in the domains of menstrual symptoms and coping strategies, choice of contraception and motherhood.This study should also stimulate communications regarding player contracts and maternity benefits, and include after career support for female professional football players.
Accreting black holes in dark matter halos
Authors: Kazempour Sobhan , Sun Sichun , Yu Chengye 
Published: August 2024

We examine the thin accretion disk behaviors surrounding black holes embedded in cold dark matter halos and scalar field dark matter halos. We first calculate the event horizons and derive the equations of motion and effective potential in black hole geometries with different dark matter halos. We then compute the specific energy, specific angular momentum, and angular velocity of particles moving along circular orbits. We also derive the effective potentials to find the locations of the innermost stable circular orbit (ISCO) and compare them to the Schwarzschild and Kerr black holes without the dark matter halos. We also use the observed ISCO of the supermassive black hole at the Galactic Center of the Milky Way, Sagittarius A*, to constrain the dark matter halos.

Published by the American Physical Society
2024
A review on computational studies on hydrogen combustion for gas turbine applications
Authors: A. Shankar , K.M. Parammasivam , Surya Narayanan Subramanian 
Published: August 2024

Purpose
The purpose of this paper is to provide an overview of the computational progress in the development of hydrogen-fired gas turbines. This review aims to identify suitable combustion models, appropriate NOx chemistry mechanisms and NOx emission levels for effective utilization of hydrogen as an alternative fuel in gas turbines.

Design/methodology/approach
Hydrogen is recognized as a potential alternative fuel for achieving exceptionally low emissions in gas turbines. The developments in conventional, trapped vortex combustor and micromix combustors are discussed, along with various computational models aimed at accurately predicting combustion and emission characteristics. The results of numerical simulations were then discussed with emphasis on their role in optimizing the combustor geometry.

Findings
Computational studies that were used to optimize the combustor geometry to reduce NOx emissions and the flashback phenomenon are discussed. To retrofit existing gas turbines for hydrogen fuel, minor modifications that are required were discussed by analyzing extensive literature. The influence of key design and geometrical parameters on NOx emissions and the appropriate selection of combustion models for numerical simulations in optimizing various combustion systems are elaborated.

Originality/value
The review emphasizes the computational studies in the progress of hydrogen-fired gas turbine developments. The previous reviews were primarily focused on the combustion technologies for hydrogen-fired gas turbines. This comprehensive review focuses on the key design parameters, flame structure, selection of combustion models, combustion efficiency improvement and impact of parametric studies on NOx formation of various combustion systems, in particular hydrogen combustion for gas turbine applications.
How and when does witnessing incivility lead to psychological distress in family-owned bank employees?
Authors: Aftab Shafaq , Saleem Irfan , Abu Mansor Nur Naha 
Published: August 2024

PurposeDrawing upon social exchange theory, this study investigates how witnessed incivility is related to psychological distress for employees. In addition, scholars dug deep into the potential moderating effect of self-esteem that links witnessed incivility, employee silence and psychological distress.Design/methodology/approachIn data were obtained from 292 bankers at family-owned banks. In this work, data analysis was performed using Smart-PLS covariance-based SEM version 4.FindingsThe study results indicate that employee silence mediates witnessed incivility and psychological distress. Findings also suggest that high self-esteem can mitigate the harmful effects of witnessed incivility, indirectly causing silence and psychological distress among employees.Practical implicationsFamily-owned bank management should encourage employees to speak up, demonstrate self-esteem and share their concerns. Thus, reducing witnessed incivility increases well-being, stress, and mental health in Pakistani family-owned enterprises which operate in diverse industries.Originality/valueIn the context of family-owned banks, our study adds context and theory to the existing body of knowledge by illuminating the underlying process that relates incivility with psychological distress By exploring the use of social exchange theory.
Compensation incentives, geographical distance, and the successful exit of indirect CVCs
Authors: Wang Han , Dong Jianwei 
Published: August 2024

PurposeThe literature suggests that increasing the intensity of compensation incentives for corporate venture capital (CVC) managers can contribute to successful exits of direct CVCs. This study explores the impact of compensation incentives on the successful exits of indirect CVCs under different geographical distances between parent companies and indirect CVC managers.Design/methodology/approachThe authors observed the compensation terms of CVC managers through investment announcements made by listed companies and used a probit regression model to test the hypotheses from a sample of 241 investment events with indirect CVCs in China.FindingsThe results show that if parent companies are geographically close to the managers of indirect CVCs, increasing the intensity of compensation incentives for managers will help the successful exit of indirect CVCs. However, if parent companies are not geographically close to indirect CVC managers, increasing the intensity of compensation incentives for managers will not promote the successful exit of indirect CVCs.Originality/valueThis study contributes significantly to the CVC literature. First, it sharpens our understanding of the differences in operational mechanisms between direct and indirect CVCs. Second, we find that the threshold returns of indirect CVC managers are non-negligible compensation incentives. Finally, the empirical evidence supports that in indirect CVC investments, the geographical distance between parent companies and managers is concerning because it affects whether compensation incentives contribute to the successful exit of indirect CVCs.
Adoption of artificial intelligence to enhance records management practices at Gauteng Department of Education in South Africa
Authors: Modiba Mashilo 
Published: August 2024

Purpose
This study aims to examine the adoption of artificial intelligence (AI) to enhance records management practices at the Gauteng Department of Education (GDE) in South Africa.

Design/methodology/approach
The study used a convergent mixed-methods research approach, employing interviews and questionnaires for data collection. Analysis of the collected data involved both verbatim and statistical methods, and the results were presented through tables and figures.

Findings
The study revealed that AI can proficiently and effectively execute all records management practices across the entire records lifecycle.

Originality/value
Consequently, the study proposed a framework that can be used as a guiding tool for the implementation and use of AI. This framework aims to enhance records management processes, not only within the GDE but also within the broader archives and records management industry.
Related party transactions and tax avoidance: does government ownership play a role?
Authors: Solikhah Badingatus , Chen Ching-Lung , Weng Pei-Yu , Al-Faryan Mamdouh Abdulaziz Saleh 
Published: August 2024

Purpose
This study aims to examine the association between related-party transactions (RPT) and tax avoidance. The study further investigates whether government ownership improves scrutiny of tax aggressiveness activities among Taiwanese group companies.

Design/methodology/approach
The authors used 16,061 firm-year observations derived from the Taiwan Economic Journal Database (TEJ) from 2005 to 2021. The authors applied GLS fixed-effect regression. Additional tests, such as a difference-in-difference examination, propensity score matching (PSM) analysis and other tests were performed to obtain more robust results.

Findings
The results show different consequences between eliminated and non-eliminated RPT toward tax avoidance. RPT enhances tax benefits aligned with the efficient contracting hypothesis. Under varying degrees of government control, this paper empirically reveals that government ownership has a role in mitigating tax avoidance. This implies that government control improves corporate governance by balancing opportunistic and efficiency-based tax avoidance.

Practical implications
This paper provides substantial practical implications since using the strategy of reducing taxes through RPT will result in greater tax savings at the business group level. Therefore, RPT is beneficial for enhancing business efficiency. Furthermore, government control increases corporate governance quality, which could lead to balancing tax aggressiveness activity.

Originality/value
Using a unique setting for RPT reporting in Taiwan, this paper divides RPT into eliminated and non-eliminated RPT. The findings offer significant insight for policymakers, investors and managers regarding the utilization of RPT to enhance efficiency in business groups. Additionally, this paper highlights the role of government control in preserving a harmonious balance in tax planning practices.
Authenticity matters: investigating virtual tours’ impact on curiosity and museum visit intentions
Authors: Chekembayeva Gaukhar , Garaus Marion 
Published: August 2024

Purpose
This study aims to investigate the impact of virtual museum tours on intentions to visit on-site museums. Furthermore, the role of an authentic virtual tour experience and its drivers is examined.

Design/methodology/approach
The results of two studies, a field study in collaboration with one of the most renowned museums in Austria (n = 227) and an online survey (n = 153), were analyzed with a series of mediation models.

Findings
Visual appeal and narrative quality were significant drivers of an authentic virtual tour experience. Curiosity mediated the positive effect of virtual tour usage intention on on-site museum visit intention.

Originality/value
Although virtual reality has been considered a promising marketing tool in tourism, no research has explored the drivers of an authentic virtual tour experience. The findings of this study not only add new insights into the role of a virtual tour’s visual appeal and narrative quality in generating authentic experience and thus prompting virtual tour usage intentions but also demonstrate that virtual tours positively impact on-site visit intentions driven by curiosity.
Using SIM-TLX to investigate the potential impacts on cognitive load while undertaking tasks in a virtual workplace
Authors: Urbano Adrian , Mortimer Michael , Horan Ben , Stefan Hans , Antlej Kaja 
Published: August 2024

Purpose
The ability to measure cognitive load in the workplace provides several opportunities to improve workplace learning. In recent years, virtual reality (VR) has seen an increase in use for training and learning applications due to improvements in technology and reduced costs. This study aims to focus on the use of simulation task load index (SIM-TLX), a recently developed self-reported measure of cognitive load for virtual environments to measure cognitive load while undertaking tasks in different environments.

Design/methodology/approach
The authors conducted a within-subject design experiment involving 14 participants engaged in digit-recall n-back tasks (1-back and 2-back) in two VR environments: a neutral grey environment and a realistic industrial ozone facility. Cognitive load was then assessed using the SIM-TLX.

Findings
The findings revealed higher task difficulty for the 2-back task due to higher mental demand. Furthermore, a notable interaction emerged between cognitive load and different virtual environments.

Research limitations/implications
This study relied solely on an n-back task and SIM-TLX self-report measure to assess cognitive load. Future studies should consider including ecologically valid tasks and physiological measurement tools such as eye-tracking to measure cognitive load.

Practical implications
Identifying cognitive workload sources during VR tasks, especially in complex work environments, is considered beneficial to the application of VR training aimed at improving workplace learning.

Originality/value
This study provides unique insights into measuring cognitive load from various sources as defined by the SIM-TLX sub-scales to investigate the impact of simulated workplace environments.