bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening the Molecular Targets of Ovarian Cancer Based on Bioinformatics Analysis
Authors: Du Lei , Qian Xiaolei , Dai Chenyang , Wang Lihua , Huang Ding , Wang Shuying , Shen Xiaowei 
Published: July 2015

Aims and background Ovarian cancer (OC) is the most lethal gynecologic malignancy. This study aims to explore the molecular mechanisms of OC and identify potential molecular targets for OC treatment. Methods and Study Design Microarray gene expression data (GSE14407) including 12 normal ovarian surface epithelia samples and 12 OC epithelia samples were downloaded from Gene Expression Omnibus database. Differentially expressed genes (DEGs) between 2 kinds of ovarian tissue were identified by using limma package in R language (|log2 fold change| >1 and false discovery rate [FDR] <0.05). Protein-protein interactions (PPIs) and known OC-related genes were screened from COXPRESdb and GenBank database, respectively. Furthermore, PPI network of top 10 upregulated DEGs and top 10 downregulated DEGs was constructed and visualized through Cytoscape software. Finally, for the genes involved in PPI network, functional enrichment analysis was performed by using DAVID (FDR <0.05). Results In total, 1136 DEGs were identified, including 544 downregulated and 592 upregulated DEGs. Then, PPI network was constructed, and DEGs CDKN2A, MUC1, OGN, ZIC1, SOX17, and TFAP2A interacted with known OC-related genes CDK4, EGFR/JUN, SRC, CLI1, CTNNB1, and TP53, respectively. Moreover, functions about oxygen transport and embryonic development were enriched by the genes involved in the network of downregulated DEGs. Conclusions We propose that 4 DEGs (OGN, ZIC1, SOX17, and TFAP2A) and 2 functions (oxygen transport and embryonic development) might play a role in the development of OC. These 4 DEGs and known OC-related genes might serve as therapeutic targets for OC. Further studies are required to validate these predictions.
Stability, Prognostic Factors and Survival of Spinal Bone Metastases in Malignant Melanoma Patients after Palliative Radiotherapy
Authors: Bostel Tilman , Förster Robert , Schlampp Ingmar , Wolf Robert , Serras Andre Franke , Mayer Arnulf , Bruckner Thomas , Welzel Thomas , Schmidberger Heinz , Debus Jürgen , Rief Harald 
Published: July 2015

Purpose This retrospective analysis aimed to evaluate the stability of spinal metastases in malignant melanoma patients following radiotherapy (RT), and to assess prognostic factors for survival. Methods Forty-one patients with malignant melanoma and osteolytic spinal bone metastases were irradiated at the university clinics of Heidelberg and Mainz between July 2003 and October 2013. Three and six months after palliative RT, only 20 and 15 patients, respectively, were still alive and were therefore assessed for spinal stability using the Taneichi score based on CT imaging. Additionally, overall survival (OS) and bone survival (BS) rates as well as prognostic factors for BS were evaluated for all study patients. Results Before RT, 19 patients (46.3%) were rated unstable. In the surviving patients, none of the unstable metastases were classified as stable 6 months after RT. Five-year OS was 23.3% and median BS was 4 months (range 0.5-29.8). Accordingly, only 36.6% of the patients were still alive 6 months after RT. Karnofsky performance score (KPS) <70%, visceral metastases and more than one bone metastasis were significantly predictive of poor BS. Conclusions Our study population was characterized by poor BS and a lack of benefit with regard to stabilization of initially unstable spinal bone metastases 3 and 6 months after RT. This applies in particular to patients with a KPS <70%, visceral metastases and multiple bone metastases. Given the limited life expectancy, short fractionated treatment schedules of RT may be preferred in this population.
Definitive Chemoradiation for Non-Small-Cell Lung Cancer: Could a Consensus be Reached?
Authors: Sayed Mona M. , El-Sayed Mohamed I. , Abdel-Wanis Mostafa E. , Abdel-Fatah Ola N. 
Published: July 2015

Aims and background There is currently no consensus as to which chemotherapy to combine with thoracic radiotherapy (TRT) in the setting of definitive chemoradiation for non-small-cell lung cancer (NSCLC). We aimed to retrospectively evaluate the efficacy and report outcome measures of cisplatin/etoposide with conventionally fractionated TRT over a 9-year period. Methods Cisplatin 50 mg/m² on days 1, 8, 29, and 36 and etoposide 50 mg/m² on days 1-5 and 29-33 with conventionally fractionated conformal radiation therapy starting on day 1 was given to 201 eligible patients. Patient records were reviewed for overall survival (OS) and progression-free survival (PFS). Results The 2-year OS and PFS were 53% and 47%, respectively, while the 3-year OS and PFS were 18% and 17%, respectively. No grade 4 or treatment-related deaths were recorded, and grade 3 hematologic toxicity occurred in only 22 patients (11%) in the form of granulocytopenia and thrombocytopenia. Multivariable analysis showed clinical stage and Eastern Cooperative Oncology Group performance status to statistically significantly affect PFS and OS. Conclusions Cisplatin and etoposide in these doses with conventionally fractionated TRT is a well-tolerated, effective treatment schedule in the definitive treatment of unresectable or inoperable NSCLC.
Bulky Mesonephric Adenocarcinoma of the Uterine Cervix Treated with Neoadjuvant Chemotherapy and Radical Surgery: Report of the First Case
Authors: Ditto Antonino , Martinelli Fabio , Bogani Giorgio , Gasparri Maria L. , Di Donato Violante , Paolini Biagio , Carcangiu Maria L. , Lorusso Domenica , Raspagliesi Francesco 
Published: July 2015

Aims and background Malignant mesonephric adenocarcinoma of the uterine cervix is a rare occurrence with few cases described in the literature. Although surgery seems to be effective in the treatment of early-stage tumor, no cases describing outcomes of locally advanced stage are available. Methods We report the first case of a patient with International Federation of Obstetrics and Gynecologists stage IIB mesonephric adenocarcinoma undergoing neoadjuvant chemotherapy and radical surgery. Conclusions Despite the inherent limitation of a single description of a case, our experience supports the utilization of neoadjuvant chemotherapy in patients with malignant mesonephric adenocarcinoma of the uterine cervix. Further prospective multi-institutional studies are needed.
Adjuvant Helical IMRT by Tomotherapy for Bulky Adrenocortical Carcinoma Operated with Positive Margins: A Case Report
Authors: Delmastro Elena , Garibaldi Elisabetta , Gabriele Domenico , Bresciani Sara , Cattari Gabriella , Di Dia Amalia , Manini Claudia , Collura Devis , Redda Maria Grazia Ruo , Gabriele Pietro 
Published: July 2015

Background Adrenocortical carcinoma (ACC) is a rare tumor in the adult. The main therapy is surgery but in some cases radiotherapy may be needed to control the disease locally. Methods A patient with a surgically removed bulky ACC and pathologic finding of a positive margin was treated at our center by adjuvant mitotane and radiotherapy using an intensity-modulated radiation therapy (IMRT)/image-guided radiotherapy (IGRT) technique by tomotherapy. Dose prescriptions were 63 Gy on the surgical bed and 50.4 Gy on the lymphatic drainage in 28 sessions. Patient compliance was good with no evidence of acute or late toxicities. Results Thirty months after radiotherapy, the patient is alive without evidence of disease checked by 18F-fluorodeoxyglucose positron emission tomography/computed tomography and without any complication. Conclusions In patients with adverse prognostic features, the delivery of adequate adjuvant radiotherapy doses with IMRT and daily IGRT is feasible and safe and could result in an improved outcome for patients with ACC.
Multistakeholder Strategic Third‐Party Logistics Provider Selection: A Real Case in China
Authors: Wang Jian‐Jun , Wang Meng‐Meng , Liu Feng , Chen Haozhe 
Published: July 2015

AbstractOutsourcing logistics to third‐party logistics (3PL) providers is becoming an increasing trend for companies seeking improved customer service and competitiveness. Choosing a suitable and competitive logistics provider has become more important than ever. In this study, we developed an evaluation and selection framework on strategic 3PL provider selection on the basis of a real case application in China. Multiple criteria and multiple stakeholders were considered to balance the various measurements in this framework. In the actual application, we chose the PROMETHEE technique as our specific evaluation method and we also assessed its effectiveness with further analysis. The results show that our proposed holistic framework is well suited for the strategic 3PL provider selection problem.
Achieving and Exceeding Logistics Outsourcing Expectations in Brazil: A Replication Study
Authors: Hofer Adriana Rossiter , Knemeyer A. Michael , Murphy Paul R. 
Published: July 2015

AbstractResponding to calls for replication research in the supply chain management literature, the current article reports the results of a replication study that looked at the performance of logistics outsourcing relationships among German logistics managers. More specifically, this article investigates the performance of logistics outsourcing relationships among Brazilian logistics managers and tests the same hypotheses as the focal study. The results indicate that the Brazilian replication is consistent with the focal study on five of the seven hypotheses. With respect to inconsistencies, the focal study found significant positive relationships between proactive improvement and logistics performance outcomes whereas the Brazilian replication did not find significant relationships between proactive improvement and logistics performance outcomes, which reflects the relevant effect of contextual differences between Germany and Brazil. The article offers both managerial and research implications along with suggestions for future research.
Recorregut de recerca geològica i mineralògica pel pais de Fois / Foix (França): des de Sant Paul de Jarrat, a Freychenet. Col de la Lauze, Montferriér, i a Montsegur
Authors: Mata Perelló Josep Maria , Sanz Balagué Joaquim 
Published: July 2015

Recorregut realitzat el 10 de juliol del 2013. El recorregut del present itinerari, es desenvoluparà íntegrament pel Sistema Pirinenc; distribuint en la seva major part per la Zona Nord – Pirinenca. Tot i així, alguns recorreguts es faran dintre de la Zona Axial del Sistema Pirinenc. Així, el recorregut començarà dintre de la primera unitat, (dintre de l´antigament anomenat Prepirineu Septentrional), per la qual es circularà entre Saint Paul – de – Jarrat i les immediacions de Freychenet. En aquest tram, s´aniran trobant afloraments dels materials mesozoics del Cretàcic. Posteriorment, el recorregut circularà per l´anomenada Zona Axial Pirinenca (pel Massif de Saint Barthélémy), entre Freychenet i el Col de la Louze. En aquest recorregut, es trobaran afloraments dels materials paleozoics del Devonià i del Carbonífer, fonamentalment. Posteriorment entre el Col de la Louze i Montsegur, el recorregut discorrerà entre les dues unitats geològiques acabades d´esmentar. Finalment, per les immediacions de Montsegur, cap a la fi del recorregut, l´itinerari anirà situant-se dintre de Zona Nord – Pirinenca. Per d´altra banda, la totalitat del recorregut es realitzarà pel País de Fois / Foix (és a dir, pel Departament de l´Ariège) per on es realitzarà la totalitat del recorregut, recorrent la vall del riu del mateix nom i algunes de les valls dels seus afluents.
Flexible Learning Itineraries Based on Conceptual Maps
Authors: Agudelo Olga Lucía , Salinas Jesús 
Published: July 2015

Abstract
The use of learning itineraries based on conceptual maps is studied in order to propose a more flexible instructional design that strengthens the learning process focused on the student, generating non-linear processes, characterising its elements, setting up relationships between them and shaping a general model with specifications for each educational level. Through a methodology built on the Successive Approximation Model (SAM), this article studies learning itinerary design, implementation and assessment process, representing, through non-linear organised conceptual maps, sets of activities leading to the development of competencies that must be understood, mastered and demonstrated. Obtained results show the adequacy of a learning itinerary based on conceptual maps of the subjects’ characteristics, solving real situations through the construction and creation of new schemes and knowledge management methods while contributing to a reflection on curricular design principles using ICT and generating learning-process autonomy.
School organization and the mobilization of teachers and students in the use of a new general secondary education curriculum in East Timor
Authors: Capelo Ana , Cabrita Isabel 
Published: July 2015

Abstract
Given that reforms involving how to deal with the past are extremely difficult, especially when the past involves memories of victimization, death, and destruction so widespread that a high percentage of the population is affected, the main purpose of this article is to describe how the general secondary education (GSE) curriculum in East Timor –an ancient Portuguese colony– is organized in terms of principles and objectives, themes, and methodo-logical guidelines that give priority to assisting students to minimize or manage problems associated with conflict. Subsequently, the current state of GSE is characterized, in terms of school organization and logistics, and mobilization of teachers and students in using the new curriculum. The empirical results show that curricular materials incorporate aspects that can contribute to understanding and minimizing or managing problems created by the conflict, as well as contributing to avoid new conflicts. Nevertheless, although textbooks incorporate these aspects and teachers and students express interest in use them, problems remain regarding their appropriate usage due to numerous factors such as: logistics; school organization and poor teacher skills, despite training given and continued focused investment.
A Multi‐institutional, Prospective, Phase II Feasibility Study of Laparoscopy‐Assisted Distal Gastrectomy with D2 Lymph Node Dissection for Locally Advanced Gastric Cancer (JLSSG0901)
Authors: Inaki Noriyuki , Etoh Tsuyoshi , Ohyama Tetsuji , Uchiyama Kazuhisa , Katada Natsuya , Koeda Keisuke , Yoshida Kazuhiro , Takagane Akinori , Kojima Kazuyuki , Sakuramoto Shinichi , Shiraishi Norio , Kitano Seigo 
Published: July 2015

AbstractBackground
The efficacy and safety outcomes of laparoscopy‐assisted distal gastrectomy (LADG) with D2 lymph node dissection for locally advanced gastric cancer remain unclear. Therefore, we conducted a randomized, controlled phase II trial to confirm the feasibility of LADG in terms of technical safety, and short‐term surgical outcomes were investigated.MethodsEligibility criteria included pre‐operatively diagnosed advanced gastric cancer that could be treated by distal gastrectomy with D2 lymph node dissection; MP, SS, and SE without involvement of other organs; and N0–2 and M0. Patients aged 20–80 years were pre‐operatively randomized.ResultsIn total, 180 patients were registered and randomized to the open (89 patients) and laparoscopic arms (91 patients). Among 91 patients in the laparoscopic arm, 86 underwent laparoscopic gastrectomy according to the study protocol. Regarding the primary endpoint of the phase II trial, the proportion of patients with either anastomotic leakage or pancreatic fistula was 4.7 % (4/86). The grade 3 or higher morbidity rate, including systemic and local complications, was 5.8 %. Conversion to open surgery was required for 1 patient (1.2 %), without any intra‐operative complication. The post‐operative mortality rate was 0, and no patient required readmission for surgical complications within 6 months after initial discharge.ConclusionsThe technical safety of LADG with D2 lymph node dissection for locally advanced gastric cancer was demonstrated. A phase III trial to confirm the non‐inferiority of this procedure to open gastrectomy in terms of long‐term outcomes is ongoing. Registered Number: UMIN 000003420 (www.umin.ac.jp/ctr/).
Chamaecyparis montane cloud forest in Taiwan: ecology and vegetation classification
Authors: Li Ching‐Feng , Zelený David , Chytrý Milan , Chen Ming‐Yih , Chen Tze‐Ying , Chiou Chyi‐Rong , Hsia Yue‐Joe , Liu Ho‐Yih , Yang Sheng‐Zehn , Yeh Ching‐Long , Wang Jenn‐Che , Yu Chiou‐Feng , Lai Yen‐Jen , Guo Ke , Hsieh Chang‐Fu 
Published: July 2015

AbstractMontane cloud forest is one of the most endangered ecosystems. However, there are few comprehensive studies on the distribution of subtropical montane cloud forest (SMCF). Chamaecyparis forest is one type of SMCF in Taiwan, distributed across the whole island. This study describes eleven types of this forest in Taiwan based on the Braun‐Blanquet approach. Plots were selected from the National Vegetation Database of Taiwan. Two alliances were defined, both of which belong to the order Fagetalia hayatae. Topography and altitude explain the contrasting habitat requirements of these two alliances, whereas seasonality of moisture, soil properties and altitude explain differences in floristic composition at the association level. The alliance of Chamaecyparidion formosanae on slopes and ridges includes coniferous or mixed coniferous and evergreen broad‐leaved forests; it is found at higher altitudes and is more influenced by the summer monsoon than the other alliance. Five associations are defined within this alliance. The alliance of Pasanio kawakamii‐Machilion japonicae growing on slopes and in valleys contains evergreen broad‐leaved forests or forests with a mixture of coniferous and evergreen broad‐leaved species. Six associations can be determined under the alliance of Pasanio kawakamii‐Machilion japonicae. Classification of each syntaxon was formalized using Cocktail Determination Key.
Discontinuous Precipitation in Ni-Base Superalloys During Solution Heat Treatment
Authors: Welton D. , D’Souza N. , Kelleher J. , Gardner S. , Dong Z. H. , West G. D. , Dong Hongbiao 
Published: July 2015

Abstract
Discontinuous precipitation in single-crystal Ni-base superalloys during solution heat treatment has been studied. It is found that discontinuous precipitation occurs at temperatures approaching the solvus, where volume diffusion is dominant. Diffusion of Al ahead of the boundary leads to gamma prime precipitation and is accompanied by a loss in the driving force available for advancement of the grain boundary. The rate of gamma prime precipitation was tracked using in situ neutron diffraction during isothermal hold. Gamma prime precipitation is accompanied by super-saturation of Cr and W within the channels ahead of the interface. The driving force calculated for the initial stages of DP was [10-5 to 10-4] N/[μm2 of the grain boundary]. The results provide an insight into discontinuous precipitation during solution heat treatment of Ni-base single-crystal alloys and are useful in optimizing the heat treatment process to avoid surface defect formation.
Aspirations of the ilium and proximal femur increase the likelihood of culturing an organism in patients with presumed septic arthritis of the hip
Authors: Schmale Gregory A. , Bompadre Viviana 
Published: July 2015

Purpose To test the hypothesis that collecting material for culture from metaphyseal bone of the ilium and proximal femur at the time of a hip aspiration will increase the sensitivity to detect an infectious organism in patients with presumed septic arthritis of the hip. Methods We retrospectively reviewed a series of 36 patients with presumed septic arthritis of the hip, based on clinical exam and serum inflammatory markers, who underwent aspirations of hip synovial fluid as well as blood from the ilium and proximal femur. Culture results from aspirates of synovial fluid and bone and tissue from capsule were compared to determine the sensitivities and specificities of a synovial aspirate alone versus synovial aspirate plus aspirates of the ilium and proximal femur to detect infection. Results The sensitivity of hip synovial fluid aspirates to detect infection via positive culture was only 63 %, though this increased significantly to 100 % when the results of cultures of aspirates of the ilium and proximal femur were included. The specificities were equivalent in both modalities (≥90 %). We conclude that obtaining aspirates of the ilium and proximal femur at the time of hip synovial fluid aspiration increases the likelihood that the procedure will return an infectious organism. Conclusion Positive cultures from a child with a septic hip or peri-articular hip infection help to efficiently and effectively guide antibiotic treatment. The child with a septic hip or peri-articular hip infection and positive cultures is likely to receive more narrow-spectrum therapy, potentially decreasing the overuse of broad-spectrum antibiotics. Level of evidence: Diagnostic study level III Development of diagnostic criteria on the basis of a series of non-consecutive patients (with universally applied reference “gold standard”).
Impact of the 2011 Revolution on Hospital Disaster Preparedness in Yemen
Authors: Aladhrai Saleem Ahmed , Djalali Ahmadreza , Della Corte Francesco , Alsabri Mohammed , El-Bakri Nahid Karrar , Ingrassia Pier Luigi 
Published: July 2015

AbstractObjectiveHospitals are expected to serve the medical needs of casualties in the face of a disaster or other crisis, including man-made conflicts. The aim of this study was to evaluate the impact of the 2011 Yemeni revolution on hospital disaster preparedness in the capital city of Sana’a.MethodsThe study was conducted in September 2011 and 2013. For evaluation purposes, the hospital emergency response checklist published by the World Health Organization (WHO) was used. Additional information was also obtained to determine what steps were being taken by hospital authorities to improve hospital preparedness.ResultsThe study selected 11 hospitals. At the time of the first evaluation, 7 hospitals were rated “unacceptable” for level of preparedness and 4 were rated “insufficient,” receiving a WHO checklist rating of 10 to 98. At the second evaluation, 5 hospitals were rated “unacceptable,” 3 “insufficient,” and 1 “effective,” receiving a rating of 9 to 134.ConclusionsUnfortunately, this study shows that between 2011 and 2013, no significant progress was made in hospital disaster preparedness in Sana’a. In a disaster-prone country like Yemen, the current situation calls for drastic improvement. Health system authorities must take responsibility for issuing strategic plans as well as standards, guidelines, and procedures to improve hospital disaster preparedness. (Disaster Med Public Health Preparedness. 2015;9:396–402)