bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empirically Supported Treatments for Panic Disorder with Agoraphobia in a Spanish Psychology Clinic
Authors: Ballesteros Francisco , Labrador Francisco J. 
Published: October 2014

AbstractThe aim of this work is to study the sociodemographic and clinical characteristics of patients diagnosed with Panic Disorder with Agoraphobia (PD/Ag), as well as the characteristics of the treatment and its results and cost in a University Psychology Clinic. Fifty patients demanded psychological assistance for PD/Ag; 80% were women, with an average age of 29.22 years (SD = 9.03). Mean number of evaluation sessions was 3.26 (SD = 1.03), and of treatment sessions, 13.39 (SD = 9.237). Of the patients, 83.33% were discharged (that is, questionnaire scores were below the cut-off point indicated by the authors, and no PD/Ag was observed at readministration of the semistructured interview), 5.5% refused treatment, and 11% were dropouts. The average number of treatment sessions of patients who achieved therapeutic success was 15.13 (SD = 8.98). Effect sizes (d) greater than 1 were obtained in all the scales. Changes in all scales were significant (p < .05). The estimated cost of treatment for patients who achieved therapeutic success was 945.12€. The treatment results are at least similar to those of studies of efficacy and effectiveness for PD/Ag. The utility of generalizing treatments developed in research settings to a welfare clinic is discussed.
Linking soil bacterial biodiversity and soil carbon stability
Authors: Mau Rebecca L , Liu Cindy M , Aziz Maliha , Schwartz Egbert , Dijkstra Paul , Marks Jane C , Price Lance B , Keim Paul , Hungate Bruce A 
Published: October 2014

Abstract
Native soil carbon (C) can be lost in response to fresh C inputs, a phenomenon observed for decades yet still not understood. Using dual-stable isotope probing, we show that changes in the diversity and composition of two functional bacterial groups occur with this ‘priming’ effect. A single-substrate pulse suppressed native soil C loss and reduced bacterial diversity, whereas repeated substrate pulses stimulated native soil C loss and increased diversity. Increased diversity after repeated C amendments contrasts with resource competition theory, and may be explained by increased predation as evidenced by a decrease in bacterial 16S rRNA gene copies. Our results suggest that biodiversity and composition of the soil microbial community change in concert with its functioning, with consequences for native soil C stability.
Electro- and Magneto-Modulated Ion Transport through Graphene Oxide Membranes
Authors: Sun Pengzhan , Zheng Feng , Wang Kunlin , Zhong Minlin , Wu Dehai , Zhu Hongwei 
Published: October 2014

AbstractThe control of ion trans-membrane transport through graphene oxide (GO) membranes is achieved by electric and magnetic fields. Electric field can either increase or decrease the ion transport through GO membranes depending on its direction and magnetic field can enhance the ion penetration monotonically. When electric field is applied across GO membrane, excellent control of ion fluidic flows can be done. With the magnetic field, the effective anchoring of ions is demonstrated but the modulation of the ion flowing directions does not occur. The mechanism of the electro- and magneto-modulated ion trans-membrane transport is investigated, indicating that the electric fields dominate the ion migration process while the magnetic fields tune the structure of nanocapillaries within GO membranes. Results also show that the ion selectivity of GO membranes can be tuned with the electric fields while the transport of ions can be enhanced synchronously with the magnetic fields. These excellent properties make GO membranes promising in areas such as field-induced mass transport control and membrane separation.
Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain
Authors: Upadhyay Urvashi M. , Tyler Betty , Patta Yoda , Wicks Robert , Spencer Kevin , Scott Alexander , Masi Byron , Hwang Lee , Grossman Rachel , Cima Michael , Brem Henry , Langer Robert 
Published: October 2014

Significance
Brain metastases represent the most common intracranial tumors in adults. Adequate chemotherapy delivery to the CNS is hindered by the blood–brain barrier. Efforts in intracranial chemotherapy delivery aim to maximize CNS levels while minimizing systemic toxicity; however, the success has been limited thus far. In this work, intracranial implanted doxorubicin and temozolomide microcapsules are compared with systemic administration in a novel rodent model of breast adenocarcinoma brain metastases. These microcapsules are versatile and efficacious, but that efficacy may depend on the ability of the chemotherapy to diffuse in brain tissue. These insights apply to other non-CNS applications of local drug delivery, and drugs should be evaluated based on their ability to penetrate the targeted tissue as well as their inherent efficacy.
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
Authors: Tan Li , Wang Jun , Tanizaki Junko , Huang Zhifeng , Aref Amir R. , Rusan Maria , Zhu Su-Jie , Zhang Yiyun , Ercan Dalia , Liao Rachel G. , Capelletti Marzia , Zhou Wenjun , Hur Wooyoung , Kim NamDoo , Sim Taebo , Gaudet Suzanne , Barbie David A. , Yeh Jing-Ruey Joanna , Yun Cai-Hong , Hammerman Peter S. , Mohammadi Moosa , Jänne Pasi A. , Gray Nathanael S. 
Published: October 2014

SignificanceInhibitors of the FGF receptors (FGFRs) are currently under clinical investigation for the treatment of various cancers. All currently approved kinase inhibitors eventually are rendered useless by the emergence of drug-resistant tumors. We used structure-based drug design to develop the first, to our knowledge, selective, next-generation covalent FGFR inhibitors that can overcome the most common form of kinase inhibitor resistance, the mutation of the so-called “gatekeeper” residue located in the ATP-binding pocket. We also describe a novel kinase inhibitor design strategy that uses a single electrophile to target covalently cysteines that are located in different positions within the ATP-binding pocket. These results have important implications for the design of covalent FGFR inhibitors that can overcome clinical resistance.
Vegetation dynamics and rainfall sensitivity of the Amazon
Authors: Hilker Thomas , Lyapustin Alexei I. , Tucker Compton J. , Hall Forrest G. , Myneni Ranga B. , Wang Yujie , Bi Jian , Mendes de Moura Yhasmin , Sellers Piers J. 
Published: October 2014

SignificanceUnderstanding the sensitivity of tropical vegetation to changes in precipitation is of key importance for assessing the fate of the Amazon rainforest and predicting atmospheric CO2levels. Using improved satellite observations, we reconcile observational and modeling studies by showing that tropical vegetation is highly sensitive to changes in precipitation and El Niño events. Our results show that, since the year 2000, the Amazon forest has declined across an area of 5.4 million km2as a result of well-described reductions in rainfall. We conclude that, if drying continues across Amazonia, which is predicted by several global climate models, this drying may accelerate global climate change through associated feedbacks in carbon and hydrological cycles.
Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart
Authors: Lavine Kory J. , Epelman Slava , Uchida Keita , Weber Kassandra J. , Nichols Colin G. , Schilling Joel D. , Ornitz David M. , Randolph Gwendalyn J. , Mann Douglas L. 
Published: October 2014

Significance
This study addresses a fundamentally important and widely debated issue in the field of inflammation, which is why inflammation can be simultaneously deleterious after injury and yet is essential for tissue repair. Recently, an important new paradigm has emerged in the macrophage field: Organs are replete with resident macrophages of embryonic origin, distinct from monocyte-derived macrophages. In this article, we use a new model of cardiac injury and show that distinct macrophage populations derived from embryonic and adult lineages are important determinants of tissue repair and inflammation, respectively. Our data suggest that therapeutics, which inhibit monocyte-derived macrophages and/or selectively harness the function of embryonic-derived macrophages, may serve as novel treatments for heart failure.
Wild chimpanzees plan their breakfast time, type, and location
Authors: Janmaat Karline R. L. , Polansky Leo , Ban Simone Dagui , Boesch Christophe 
Published: October 2014

Significance
How do large-brained primates maintain high rates of energy intake when times are lean? By analyzing early-morning departure times and sleeping nest positioning of female chimpanzees as a function of the ephemerality of next day’s breakfast fruit and its location, we found evidence that wild chimpanzees flexibly plan when and where they will have breakfast after weighing multiple factors, such as the time of day, their egocentric distance to, and the type of food to be eaten. To our knowledge, our findings reveal the first clear example of a future-oriented cognitive mechanism by which hominoids, like great apes, can buffer the effect of seasonal declines in food availability and increased interspecific competition to facilitate first access to nutritious food.
Dynamic population mapping using mobile phone data
Authors: Deville Pierre , Linard Catherine , Martin Samuel , Gilbert Marius , Stevens Forrest R. , Gaughan Andrea E. , Blondel Vincent D. , Tatem Andrew J. 
Published: October 2014

SignificanceKnowing where people are is critical for accurate impact assessments and intervention planning, particularly those focused on population health, food security, climate change, conflicts, and natural disasters. This study demonstrates how data collected by mobile phone network operators can cost-effectively provide accurate and detailed maps of population distribution over national scales and any time period while guaranteeing phone users’ privacy. The methods outlined may be applied to estimate human population densities in low-income countries where data on population distributions may be scarce, outdated, and unreliable, or to estimate temporal variations in population density. The work highlights how facilitating access to anonymized mobile phone data might enable fast and cheap production of population maps in emergency and data-scarce situations.
Defense mutualisms enhance plant diversification
Authors: Weber Marjorie G. , Agrawal Anurag A. 
Published: October 2014

Significance
Plants that provide food and housing to animals in return for defense against enemies are classic examples of mutualistic partnerships in nature. Here, we show that the evolution of such plant–animal mutualisms also can lead to a trajectory of accelerated accumulation of plant species in the lineages that participate in these cooperative interactions. We found that the evolution of plant organs (extrafloral nectaries) that facilitate mutualisms with animal defenders was repeatedly followed by increased rates of diversification across distantly related plant lineages. These results suggest that by enabling ecological interactions with animals, the convergent evolution of relatively simple glands changed the course of plant evolution toward greater protection from pests and accelerated the generation of biodiversity.
Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney
Authors: Ebrahimkhani Mohammad R. , Daneshmand Ali , Mazumder Aprotim , Allocca Mariacarmela , Calvo Jennifer A. , Abolhassani Nona , Jhun Iny , Muthupalani Sureshkumar , Ayata Cenk , Samson Leona D. 
Published: October 2014

Significance
Ischemia reperfusion (I/R)-induced tissue injury and inflammation encompasses a wide range of human disease, including stroke, hepatic and renal failure, and myocardial infarction. Generation of highly reactive oxygen and nitrogen species during I/R results in DNA damage that is subject to numerous DNA repair processes. Base excision repair (BER) initiated by various DNA glycosylases is critical for the repair of reactive oxygen and nitrogen species (RONS)-induced DNA damage. Our data describe a new paradigm wherein the Aag BER DNA glycosylase enzyme promotes, rather than prevents, tissue injury and inflammation in liver, brain, and kidney following I/R. This finding reveals a detrimental facet of DNA repair during inflammation and presents a novel target for controlling I/R-induced injury.
Developing functional musculoskeletal tissues through hypoxia and lysyl oxidase-induced collagen cross-linking
Authors: Makris Eleftherios A. , Responte Donald J. , Paschos Nikolaos K. , Hu Jerry C. , Athanasiou Kyriacos A. 
Published: October 2014

Significance
The inadequate mechanical properties of engineered tissues have prevented related therapies from clinical translation. Collagen cross-links correlate with the mechanical integrity of tissues; however, addressing the weakness of neotissues through enhancing collagen cross-links has not received the attention it deserves. The present study demonstrates, both in vitro and in vivo, that improvements in the mechanical properties of native and engineered tissues can be attained using endogenous (hypoxia-mediated) lysyl oxidase and exogenous application of lysyl oxidase-like 2, which are enzymes responsible for collagen cross-linking. By promoting an ∼16-fold increase in collagen cross-linking and, concomitantly, an approximately fivefold enhancement in the neotissue’s mechanical properties, this work creates new prospects for regenerative medicine. The methods developed here work across a spectrum of collagen-rich tissues and are clinically applicable.
Mating-type switching by chromosomal inversion in methylotrophic yeasts suggests an origin for the three-locusSaccharomyces cerevisiaesystem
Authors: Hanson Sara J. , Byrne Kevin P. , Wolfe Kenneth H. 
Published: October 2014

SignificanceSaccharomyces cerevisiaeundergoes a programmed DNA rearrangement to switch between mating types a and alpha. The origins of this complex and multifaceted process, which requires three copies of the mating-type (MAT) locus (with two silenced), have remained unknown. In this study we present a mechanism for mating-type switching in methylotrophic yeasts that shares a common origin with the well-characterized system inS.cerevisiaebut has simpler components. This system requires only two copies of theMATlocus, with one copy transcriptionally repressed by proximity to centromeric or telomeric chromatin. Switching between the mating types occurs by recombination between inverted-repeat sequences flanking theMATloci. This system suggests an ancestral mechanism for mating-type switching in yeasts.
Multiple patterns of polymer gels in microspheres due to the interplay among phase separation, wetting, and gelation
Authors: Yanagisawa Miho , Nigorikawa Shinpei , Sakaue Takahiro , Fujiwara Kei , Tokita Masayuki 
Published: October 2014

Significance
We investigate how microdroplet confinement affects pattern formation of a polymer blend in the liquid-and-gel coexisting phase, wherein interactions between the droplet surface and the polymers regulate wettability of the gelation polymer. The complete and partial wetting of the polymers produces two stable states: hollow microspheres and hemisphere microgels. In addition, gelation during phase separation produces various shapes as trapped states. The relation between capsule thickness and droplet size is changed by the dynamical coupling. Furthermore, multiple patterns with spherical asymmetric shapes are produced by the partial wetting and shape deformation along the phase boundaries between the sol/gel phases. These findings reveal a complex pattern formation arising from the interplay among the interfacial tensions, gel elasticity, and wetting in microspheres.
Enhanced in vitro caulogenesis and quantitative estimation of aloin through HPLC in Aloe vera
Authors: Sharma V. , Guleria M. , Chaudhary P. 
Published: October 2014

Aloe vera(Liliaceae) is well known for its medicinal properties. It contains flavonoids, saponins, tannins, alkaloids and other compounds which exhibit medicinal, cosmetic and pharmacological properties. There is a lack of production of aloe leaf to meet the industry demand and therefore the means to facilitate large-scale aloe cultivation schemes need to be developed. Because sexual reproduction by seeds is almost ineffective inAloe veradue to male sterility and vegetative propagation by offshoots is only possible during the growing seasons, there is a need to develop a propagation method to facilitate large-scale cultivation.In vitroregeneration of medicinal plants is important and there is the potential for the production of high-quality plant-based medicine. In the present study, an attempt has been made to enhancein vitrocaulogenesis and aloin content in plants in the presence of a precursor (tryptophan) in the nutrient media. Forin vitroculture establishment and shoot bud multiplication, MS basal media were used supplemented with different concentrations and different combinations of growth regulators such as BAP (6-benzylaminopurine) and IAA (3-indole acetic acid). Shoot proliferation was optimal in MS medium containing 2.0 mg l−1BAP. For evaluation ofin vitroenhancement of aloin production the precursor tryptophan was added to the nutrient media at different levels (5, 10, 15 and 20 mg l−1). Addition of 20 mg l−1tryptophan induced a 2.43-fold increase in aloin content in multiple shoots cultures ofAloe barbadensis.
Enhanced butanol production by eukaryotic Saccharomyces cerevisiae engineered to contain an improved pathway
Authors: Sakuragi Hiroshi , Morisaka Hironobu , Kuroda Kouichi , Ueda Mitsuyoshi 
Published: October 2014

Abstract
Compared with ethanol, butanol has more advantageous physical properties as a fuel, and biobutanol is thus considered a promising biofuel material. Biobutanol has often been produced by Clostridium species; however, because they are strictly anaerobic microorganisms, these species are challenging to work with. We attempted to introduce the butanol production pathway into yeast Saccharomyces cerevisiae, which is a well-known microorganism that is tolerant to organic solvents. 1-Butanol was found to be produced at very low levels when the butanol production pathway of Clostridium acetobutylicum was simply introduced into S. cerevisiae. The elimination of glycerol production pathway in the yeast contributed to the enhancement of 1-butanol production. In addition, by the use of trans-enoyl-CoA reductase in the engineered pathway, 1-butanol production was markedly enhanced to yield 14.1 mg/L after 48 h of cultivation.
Roles of Ala-149 in the catalytic activity of diadenosine tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv
Authors: Mori Shigetarou , Kim Hyun , Rimbara Emiko , Arakawa Yoshichika , Shibayama Keigo 
Published: October 2014

Abstract
Diadenosine 5′,5′′′-P1,P4-tetraphosphate (Ap4A) phosphorylase from Mycobacterium tuberculosis H37Rv (MtAPA) belongs to the histidine triad motif (HIT) superfamily, but is the only member with an alanine residue at position 149 (Ala-149). Enzymatic analysis revealed that the Ala-149 deletion mutant displayed substrate specificity for diadenosine 5′,5′′′-P1,P5-pentaphosphate and was inactive on Ap4A and other substrates that are utilized by the wild-type enzyme.
Vertical and Horizontal Movements of Yellowfin Tuna in the Gulf of Mexico
Authors: Hoolihan J. P. , Wells R. J. D. , Luo J. , Falterman B. , Prince E. D. , Rooker J. R. 
Published: October 2014

Abstract
Pop up satellite archival tags (n = 31) were deployed on Yellowfin Tuna Thunnus albacares in the Gulf of Mexico for periods ranging from 14 to 95 d. Differences in diel vertical behavior were assessed by comparing time spent at temperature relative to the surface temperature (ΔT). Pooled samples revealed that 31% of darkness hours, 20% of twilight hours, and 12% of daylight hours were spent in the uniform temperature surface layer (i.e., ΔT = 0). Total time spent above 100 m was less during daylight (90.0%) than during darkness (99.8%), suggesting greater exploration of deeper depths during daylight hours. Maximum depth visited ranged from 208 to 984 m, and minimum temperature visited ranged from 5.4°C to 11.8°C. Only a small proportion of total time was spent at temperatures colder than 8°C below the surface temperature. Horizontal excursions for the majority of individuals were less than 100 km from the point of release; however, three individuals moved distances of 411–1,124 km, suggesting that this species has the capability to move relatively long distances within the Gulf of Mexico. The ΔT values are provided in tabular format and serve as direct input variables for use in habitat standardization models.
Received January 7, 2014; accepted June 8, 2014
Impaired Exercise Capacity following Atrial Septal Defect Closure: An Invasive Study of the Right Heart and Pulmonary Circulation
Authors: Santos Mário , Systrom David , Epstein Stephen E. , John Anitha , Ruiz George , Landzberg Michael J. , Opotowsky Alexander R. 
Published: October 2014

Patients with early repair of an isolated atrial septal defect (ASD) are expected to have unremarkable right ventricular (RV) and pulmonary circulation physiology. Some studies, however, suggest persistent functional impairment. We aimed to examine the role of abnormal RV and pulmonary vascular response to exercise in patients who had undergone ASD closure. Using a previously published data set, we reviewed invasive exercise cardiopulmonary testing with right‐sided hemodynamic data for 12 asymptomatic patients who had undergone ASD closure. The 5 (42%) patients with impaired maximal oxygen uptake (o2max) were older and exhibited a lower peak cardiac index (5.6 ± 0.8 vs. 9.0 ± 1.2 L/min/m2; P =. 005) because of abnormal stroke volume augmentation (+3.2 ± 3.9 vs. +17.4 ± 10.2 mL/m2; P =. 02). While all resting hemodynamic variables were similar, patients with low o2max tended to have abnormal total pulmonary vascular resistance change during exercise (+11% ± 41% vs. ?28% ± 26%; P =. 06) and had a steeper relation between mean pulmonary arterial pressure and cardiac index (5.8 ± 0.6 vs. 2.2 ± 0.1 L/min/m2; P =. 02). The increase in peak mean RV power during exercise was also significantly lower in the impaired‐o2max patients (4.7 ± 1.6 vs. 7.6 ± 2.1 J/s; P =. 04). As described in the original study, despite normal resting hemodynamics, a subset of asymptomatic patients with repaired ASD had diminished exercise capacity. Our analysis allows us to conclude that this is due to a combination of abnormal pulmonary vascular response to exercise and impaired RV function.
Inefficiency of Male and Female Labor Supply in Agricultural Households: Evidence from Uganda
Authors: Andrews Martyn J. , Golan Jennifer , Lay Jann 
Published: October 2014

AbstractThis article analyzes the efficiency of the intra‐household allocation of female and male labor inputs in agricultural production. In a collective household model, spouses’ optimal on‐farm labor supply is such that the marginal rate of technical substitution between male and female labor is equated over different crops. Using the Uganda National Household Survey 2005/06, we test whether this condition holds by estimating production functions and controlling for endogeneity using a method proposed by Gandhi, Navarro, and Rivers (2009). We find that women are less productive than men, that there is more female labor input on low productivity parcels, and that men are relatively more productive on female‐controlled plots compared with male‐controlled plots. Total farm output could be higher and Pareto improvements could be possible if male labor was reallocated to female‐controlled plots and/or female labor was reallocated to male‐controlled plots.