bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: One‐Pot Three‐Component Sulfone Synthesis Exploiting Palladium‐Catalyzed Aryl Halide Aminosulfonylation.
Authors: Richards‐Taylor Charlotte S. , Blakemore David C. , Willis Michael C. 
Published: June 2014

AbstractThe title reaction combines aryl‐ or alkenyl iodides (I) and (IV) with a sulfonyl unit and an electrophilic coupling fragment, such as alkyl halides or electron‐poor arenes, e.g. (VIII), to provide the corresponding sulfone products (III), (V), (VII), and (IX) in good to high yields.
ChemInform Abstract: Chlorotrimethylsilane (TMSCl): An Efficient Silicon‐Based Lewis Acid Mediator in Allylic Alkylation Using a Diethylzinc Reagent.
Authors: Deng Wen‐Hui , Ye Fei , Bai Xing‐Feng , Li Li , Song Tao , Wei Yun‐Long , Xu Li‐Wen 
Published: June 2014

AbstractAllylic alkylation of 1,3‐diaryl‐2‐propenyl acetates leads to 1,3‐diarylpent‐1‐enes without any enantiomeric excess.
ChemInform Abstract: Studies Towards the Total Synthesis of Hygrocins A and B.
Authors: Rasapalli Sivappa , Jarugumilli Gopalakrishna , Yarrapothu Gangadhara Rao , Ijaz Hamza , Golen James A. , Williard Paul G. 
Published: June 2014

AbstractCompound (I) is successfully synthesized, which represents the western segment of the title compounds.
ChemInform Abstract: Synthesis and Antiproliferative Evaluation of Amide‐Containing Anthraquinone, Xanthone, and Carbazole.
Authors: Chen Li‐Chai , Juang Shin‐Hun , Chang Ken‐Ming , Tzeng Cherng‐Chyi , Chen Jih‐Jung , Chen I‐Li , Wang Tai‐Chi 
Published: June 2014

AbstractThe synthesized compounds are screened for their in vitro antiproliferative activities against some human cancer cell lines.
ChemInform Abstract: Novel Stereoselective Synthesis of Spiroketal Structure Using Pd(II)‐Catalyst.
Authors: Miyazawa Masahiro , Eizawa Toru , Yoshihara Shoko , Hatanaka Akinori , Yokoyama Hajime , Hirai Yoshiro 
Published: June 2014

AbstractA highly stereoselective palladium(II)‐catalyzed intramolecular cyclization of 1,11‐dihydroxyundec‐9‐en‐5‐one derivatives via unstable hemiacetal intermediates is reported.
ChemInform Abstract: Palladium‐Catalyzed Unactivated C(sp3)—H Bond Activation and Intramolecular Amination of Carboxamides: A New Approach to β‐Lactams.
Authors: Sun Wen‐Wu , Cao Pei , Mei Ren‐Qiang , Li Yue , Ma Yuan‐Liang , Wu Bin 
Published: June 2014

AbstractThe described intramolecular C‐N bond formation process is compatible with a broad range of functional groups and is successfully applied in the synthesis of fused ring systems, which is rarely achieved by other methodologies.
ChemInform Abstract: Benzenesulfonyl Chlorides: New Reagents for Access to Alternative Regioisomers in Palladium‐Catalyzed Direct Arylations of Thiophenes.
Authors: Yuan Kedong , Doucet Henri 
Published: June 2014

AbstractThe Pd‐catalyzed coupling of benzenesulfonyl chlorides (II) with thiophene derivatives, such as (I), (IV), and (VI) allows regioselective access to β‐arylated thiophenes (III), (V), and (VII), respectively.
ChemInform Abstract: Towards a Facile and Convenient Synthesis of Highly Functionalized Indole Derivatives Based on Multi‐Component Reactions.
Authors: Neochoritis Constantinos G. , Doemling Alexander 
Published: June 2014

AbstractA novel indole isocyanide (IV) is synthesized through accelerated Leuckart—Wallach reaction and subsequently employed in important multi‐component reactions leading to potential bioactive compounds.
ChemInform Abstract: Regioselective Synthesis of 1,3,5‐Trisubstituted Pyrazoles from N‐Alkylated Tosylhydrazones and Terminal Alkynes.
Authors: Kong Yuanfang , Tang Meng , Wang Yun 
Published: June 2014

AbstractThis efficient protocol can be applied to a wide range of substrates and tolerating a variety of substituents, including both electron‐donating and ‐withdrawing groups.
ChemInform Abstract: Expedient Synthesis of α‐Heteroaryl Piperidines Using a Pd‐Catalyzed Suzuki Cross‐Coupling—Reduction Sequence.
Authors: Hesp Kevin D. , Fernando Dilinie P. , Jiao Wenhua , Londregan Allyn T. 
Published: June 2014

AbstractThe method provides a robust strategy towards α‐azine piperidines which are not accessible using standard approaches like reduction of 2‐aryl pyridines.
ChemInform Abstract: Samarium(III)‐Catalyzed C(sp3)—H Bond Activation: Synthesis of Indolizines via C—C and C—N Coupling Between 2‐Alkylazaarenes and Propargylic Alcohols.
Authors: Wang Xu , Li Shen‐yan , Pan Ying‐ming , Wang Heng‐shan , Liang Hong , Chen Zhen‐feng , Qin Xiao‐huan 
Published: June 2014

AbstractThe reaction proceeds under solvent‐free conditions and tolerates a wide range of functional groups.
ChemInform Abstract: Metal Modified SSA as a Heterogeneous Catalyst to Promote the Cyclocondesation of O‐Aminobenzonitriles with Cycloketones in Water.
Authors: Zhang Li Jun , Yu Jian Ling , Wang Wei Li , Li Heng , Xu Dan Dan , Bi Ya Dong , Liu Fu De 
Published: June 2014

AbstractA novel solid catalyst based on silica sulfuric acid (SSA) is prepared.
ChemInform Abstract: Reaction of Hexafluoro‐N‐(4‐N,N‐dialkylaminophenyl)‐1,4‐naphthoquinon‐4‐imines with Primary Amines.
Authors: Ektova L. V. , Bukhtoyarova A. D. , Chuikov I. P. , Beregovaya I. V. 
Published: June 2014

AbstractThe reaction of hexafluoro‐N‐imines (I) with primary amines (II) affords amino‐substituted compounds (III) and the corresponding cyclized products (IV).
ChemInform Abstract: Copper‐Catalyzed Trifluoromethylselenolation of Aryl and Alkyl Halides: The Silver Effect in Transmetalation.
Authors: Chen Chaohuang , Hou Chuanqi , Wang Yuguang , Hor T. S. Andy , Weng Zhiqiang 
Published: June 2014

AbstractThe presented method is applicable to a broad range of aryl, heteroaryl, and alkyl halides giving high yields and is compatible with a high number of functional groups.
ChemInform Abstract: Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (‐)‐Trigonoliimines.
Authors: Han Sunkyu , Morrison Karen C. , Hergenrother Paul J. , Movassaghi Mohammad 
Published: June 2014

AbstractFull details of the enantioselective total syntheses of all known (‐)‐trigonoliimine alkaloids already shortly reported in 2011 (see CI 2011‐50‐182) are given that had enabled the revision of the absolute stereochemistry of trigonoliimine A (Ia), B (Ib), and C (II).
ChemInform Abstract: Asymmetric Synthesis of (+)‐(S)‐Massoia Lactone (III), Pheromone of Idea leuconoe. Formal Total Synthesis of Valilactone and Lachnelluloic Acid (II).
Authors: Mineeva I. V. 
Published: June 2014

AbstractAn asymmetric synthesis is presented for lactone (I) which contains the cyclic scaffold of valilactone.
ChemInform Abstract: Carbamidocyclophanes F and G with anti‐Mycobacterium tuberculosis Activity from the Cultured Freshwater Cyanobacterium Nostoc sp.
Authors: Luo Shangwen , Kang Hahk‐Soo , Krunic Aleksej , Chlipala George E. , Cai Geping , Chen Wei‐Lun , Franzblau Scott G. , Swanson Steven M. , Orjala Jimmy 
Published: June 2014

AbstractCarbamidocyclophane F (Ia) shows a potent anti‐Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low‐oxygen‐recovery assay with MIC values of 0.8 and 5.4 μM, respectively.
ChemInform Abstract: Coibacins A and B: Total Synthesis and Stereochemical Revision.
Authors: Carneiro Vania M. T. , Avila Carolina M. , Balunas Marcy J. , Gerwick William H. , Pilli Ronaldo A. 
Published: June 2014

AbstractCoibacin A (I) is prepared in 12 steps and 3.4% overall yield.
ChemInform Abstract: Sulfur‐Containing Derivatives of Mono‐ and Bicyclic Natural Monoterpenoids
Authors: Ishmuratov G. Yu. , Yakovleva M. P. , Tukhvatshin V. S. , Talipov R. F. , Nikitina L. E. , Artemova N. P. , Startseva V. A. , Tolstikov A. G. 
Published: June 2014

AbstractReview: 102 refs.
Low‐Temperature Synthesis of Crystalline Inorganic/Metallic Nanocrystal‐Halloysite Composite Nanotubes
Authors: Li Cuiping , Wang Jiaqiang , Feng Siquan , Liu Zan 
Published: June 2014

AbstractWe have demonstrated a facile approach for the low‐temperature synthesis of crystalline inorganic/metallic nanocrystal‐halloysite composite nanotubes by employing the bulk controlled synthesis of inorganic/metallic nanocrystals on halloysite nanotubes. The halloysite clay nanotubes can adsorb the target precursor and induce inorganic/metallic nanocrystals to grow in situ. The crystalline phase and morphology of the composite clay nanotubes is tunable. By simply tuning the acidity of the titania sol, the crystalline titania‐clay nanotubes with tunable crystalline phases of anatase, a mixture of anatase and rutile or rutile are achieved. The approach is general and has been extended to synthesize the representative perovskite oxide (barium and strontium titanate)‐halloysite composite nanotubes. Metallic nickel nanocrystal can also be grown on the surface of halloysite nanotubes at low temperature. The traditional thermal treatment for crystallite transformation is not required, thus intact contour of halloysite nanotubes and the crystallinity structure of halloysite nanotubes can be guaranteed. The combined properties from inorganic/metallic nanocrystal (high refractive index, high dielectric constant and catalytic ability) and the halloysite clay nanotubes are promising for applications such as photonic crystals, high‐k‐gate dielectrics, photocatalysis and purification.
Synthesis and Insecticidal Evaluation of Novel Phthalic Diamides Containing 1,2,3‐Triazoles via Click Reaction
Authors: Chen Yinbo , Xiao Youxin , Shao Xusheng , Xu Xiaoyong , Li Zhong 
Published: June 2014

AbstractA series of novel phthalic diamide derivatives containing 1,2,3‐triazole moiety were synthesized using one‐pot click chemistry approach and characterized by 1H NMR and HRMS. The insecticidal activity against armyworm (Mythimna separata), Tetranychu scinnabarinus and cowpea aphid (Aphis craccivora) was evaluated. Compounds 4II‐a and 4II‐i showed 50% insecticidal activity against armyworm (Mythimna separata) at the concentration of 4 mg/L and one‐third of the compounds had moderate activity against Tetranychus cinnabarinus at 500 mg/L.
Activation of nuclear factor κB pathway and downstream targets survivin and livin by SHARPIN contributes to the progression and metastasis of prostate cancer
Authors: Zhang Yiming , Huang Hai , Zhou Huimin , Du Tao , Zeng Lexiang , Cao Yi , Chen Jieqing , Lai Yiming , Li Jin , Wang Ganping , Guo Zhenghui 
Published: June 2014

BACKGROUNDNuclear factor κB (NFκB) signaling is strongly associated with tumor progression, and studies have shown that SHANK‐associated RH domain interacting protein (SHARPIN) is crucial for NFκB pathway activation. However, the expression and functions of SHARPIN in prostate cancer (PCa) have not yet been defined.METHODSThe expression of SHARPIN in PCa cell lines and tissues was evaluated with western blotting, quantitative real‐time polymerase chain reaction, and immunohistochemistry. After SHARPIN was silenced in the PCa cell lines, western blots were used to confirm that SHARPIN physically associated with components of the NFκB pathway and the downstream targets (survivin and livin). The functions of SHARPIN in cell proliferation, migration, and invasion in vitro were measured with 5‐(3‐carboxymethoxyphenyl)‐2‐(4,5‐dimenthylthiazoly)‐3‐(4‐sulfophenyl)tetrazolium, inner salt (MTS), Transwell, and invasion assays, respectively. Flow cytometry was employed to evaluate cell apoptosis. Furthermore, tumorigenesis in vivo was examined with tumorigenicity assays.RESULTSSHARPIN expression was upregulated in PCa cell lines and tissues. The knockdown of SHARPIN or incubation with Bay 11‐7082 (an NFκB inhibitor) led to dramatically decreased levels of phosphorylated IκBα and phosphorylated p65 in comparison with the control group. Downregulation of survivin and livin due to SHARPIN inhibition was attributable to transcriptional repression (P < .05). Decreases in cell viability, migration, invasion, and survival with a higher sensitivity to docetaxel in vitro and with repressed tumorigenesis in vivo were observed upon SHARPIN silencing, and this was consistent with the results from inhibition of the NFκB pathway and its downstream targets.CONCLUSIONThe current study demonstrates that overexpression of SHARPIN promotes activation of the NFκB pathway and downstream targets survivin and livin, which potentially contributes to PCa development. Cancer 2014;120:3208–3218. ©2014 American Cancer Society.
Retrospective cohort study evaluating the impact of intraperitoneal morcellation on outcomes of localized uterine leiomyosarcoma
Authors: George Suzanne , Barysauskas Constance , Serrano César , Oduyebo Titilope , Rauh‐Hain Jose A. , Del Carmen Marcela G. , Demetri George D. , Muto Michael G. 
Published: June 2014

BACKGROUNDUterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in inadvertently morcellated ULMS with resultant intraperitoneal dissemination of tumor. The objective of this study was to assess the impact of intraperitoneal morcellation on the outcomes of patients with ULMS.METHODSIn this retrospective cohort study, all patients with ULMS who attended the authors' institutions from 2007 to 2012 were reviewed. Demographics and outcomes were compared between those who underwent morcellation or total abdominal hysterectomy (TAH) as their first surgery for uterus‐limited ULMS.RESULTSIn total, 58 patients were identified, including 39 who underwent TAH and 19 who underwent intraperitoneal morcellation. Intraperitoneal morcellation was associated with a significantly increased risk of abdominal/pelvic recurrences (P = .001) and with significantly shorter median recurrence‐free survival (10.8 months vs 39.6 months; P = .002). A multivariate adjusted model demonstrated a >3 times increased risk of recurrence associated with morcellation (hazard ratio, 3.18; 95% confidence interval, 1.5‐6.8; P = .003).CONCLUSIONSIntraperitoneal morcellation of presumed leiomyoma worsens the outcomes of women with ULMS. Because there are no reliable preoperative techniques to distinguish ULMS from benign leiomyoma, all efforts to minimize intraperitoneal uterine morcellation should be considered. [See editorial on pages 000‐000, this issue.] Cancer 2014;120:3154–3158. © 2014 American Cancer Society.
Ion Pairing in Protic Ionic Liquids Probed by Far‐Infrared Spectroscopy: Effects of Solvent Polarity and Temperature
Authors: Fumino Koichi , Fossog Verlaine , Stange Peter , Wittler Kai , Polet Wigbert , Hempelmann Rolf , Ludwig Ralf 
Published: June 2014

AbstractThe cation–anion and cation–solvent interactions in solutions of the protic ionic liquid (PIL) [Et3NH][I] dissolved in solvents of different polarities are studied by means of far infrared vibrational (FIR) spectroscopy and density functional theory (DFT) calculations. The dissociation of contact ion pairs (CIPs) and the resulting formation of solvent‐separated ion pairs (SIPs) can be observed and analyzed as a function of solvent concentration, solvent polarity, and temperature. In apolar environments, the CIPs dominate for all solvent concentrations and temperatures. At high concentrations of polar solvents, SIPs are favored over CIPs. For these PIL/solvent mixtures, CIPs are reformed by increasing the temperature due to the reduced polarity of the solvent. Overall, this approach provides equilibrium constants, free energies, enthalpies, and entropies for ion‐pair formation in trialkylammonium‐containing PILs. These results have important implications for the understanding of solvation chemistry and the reactivity of ionic liquids.
Self‐Organization of Polar Porphyrinoids
Authors: Babu Sukumaran Santhosh , Bonifazi Davide 
Published: June 2014

AbstractThis Minireview focuses on the very recent developments in the field of porphyrin‐based self‐assembled nanomaterials with a particular focus on the use of tetrapyrrolic macrocycles bearing amphiphilic and ionic functionalities. As one of the most studied molecular materials, the importance of porphyrin‐derived nanomaterials has attracted wide interest in many applications like catalysis, photodynamic therapy, and organic solar cells to name a few. By using key examples that have recently appeared in the literature, the discussion unfolds through two sections: amphiphilic and ionic assemblies. Although it focuses on the nanostructuring methodologies used to obtain organized materials, the discussion will also target the physical characterization of the functional materials for their implementation in prototypes.
Application of FT‐NIR spectroscopy in assessment of used frying fats and oils*
Authors: Gertz Christian , Behmer Dagmar 
Published: June 2014

NIR spectroscopy (NIRS) was used to develop a fast and cost‐effective method to assess the quality of deep‐frying oil. A large number of fresh, used and discarded oils, used in fast food units, restaurants, fisheries, bakeries, and other frying industries, were analyzed for relevant parameters of thermo‐oxidative fat degradation such as total polar compounds (TPC), di‐ and polymerized tri‐acylglycerols (DPTG), anisidine value (AnV) and acid value (AV) using the standard DGF methods. Additionally, the fatty acid composition, including trans fatty acids, iodine value (IV) and the contents of monomeric oxidized tri‐acylglycerols (MonoxTG) were determined to describe the nutritional value of fried food. MonoxTG is a mixture of oxidized triglycerides of different molecular weight forming two groups separated in GPC. It is suggested to call them total oxidized products (TOP) as both groups of monomeric oxidized TAGs characterize, objectively and reliably, the whole spectrum of oxidized products in a used frying oil in contrast to AnV. Typical concentrations of this group of oxidized monomeric tri‐acylglycerols (TOP) in frying oils are 3 up to 15%. High calibration accuracy was obtained for all NIRS determinations. All methods were validated using test set validations. Partial least squares regression (PLS) was used to correlate spectral data with TPC, TOP, DPTG, AV, and AnV. High calibration accuracy was obtained for the NIR determination of all parameters analyzing used frying oils. For the TPC, the coefficient of determination R2 was 97.6 with an RMSEP of 1.56% over a range from 2.0 to 50.3%. Also DPTG was predicted successfully with R2 = 99.4 and RMSEP = 0.47% (0–31.3%). The AnV was measured over a broad range of 0.1 to 173 with R2 = 95.7 and RMSEP = 6.8. For acidity expressed as AV covering a wide range from 0 to 5.7 the R2 value was 97.4% with an RMSEP of 0.17%. A new parameter to monitor the degree of oxidation (TOP) has shown an R2 = 96.8 and RMSEP = 0.57%Practical applications: NIRS is a useful tool for monitoring the thermo‐oxidative changes in used frying fats and oils during the frying process. This helps to optimize the frying process and to improve the quality of the food to be fried. From the results obtained in this study, it can be deduced that the determination of the TPC is not sufficient. The determination of all oxidized monomeric triglycerides TOP provide better information of those compounds which are discussed to have a detrimental effect to human health.
Effect of cropping systems on heavy metal distribution and mercury fractionation in the Wanshan mining district, China: Implications for environmental management
Authors: Wang Jianxu , Feng Xinbin , Anderson Christopher W.N. , Qiu Guangle , Bao Zhengduo , Shang Lihai 
Published: June 2014

Abstract

The authors studied the concentration of heavy metals and mercury fractionation in contaminated soil in 2 agricultural land use systems (paddy rice and dry land) at the Wanshan mercury mine in China. The average concentrations of chromium, lead, copper, nickel, and zinc were generally lower in paddy rice soil relative to corn field soil. Soil under corn field production was slightly contaminated with lead (22–100 mg/kg), copper (31–64 mg/kg), and nickel (22–76 mg/kg) and moderately contaminated with zinc (112–635 mg/kg). In both soils, correlation of these metals with the titanium concentration in the soil indicates a geogenic origin for each metal (lead, r = 0.48; copper, r = 0.63; nickel, r = 0.47; zinc, r = 0.48). The mercury and antimony concentration in soil was high under both cropping systems, and future remediation efforts should consider the potential environmental risk presented by these metals. The concentration of bioavailable mercury in soil ranged from 0.3 ng/g to 11 ng/g across the 2 cropping systems. The majority of mercury (&gt;80%) was associated with organic matter and the residual fraction. However, soil under paddy rice production exhibited a significantly lower concentration of Fe/Mn oxide–bound mercury than that under corn field production. This may be a function of the reduction of Fe/Mn oxides in the paddy rice soil, with the subsequent release of adsorbed metals to the soil solution. Sequential change from corn field to paddy rice production, as practiced in Wanshan, should therefore be avoided. Mercury adsorbed to Fe/Mn oxides in corn field soil potentially could be released into the soil solution and be made available for biomethylation under the flooded water management conditions of a rice paddy. Environ Toxicol Chem 2014; 33:2147–2155. © 2014 SETAC
Processing of gelatin‐based cryogels with improved thermomechanical resistance, pore size gradient, and high potential for sustainable protein drug release
Authors: Gorgieva Selestina , Kokol Vanja 
Published: June 2014

AbstractPorous gelatin (GEL) cryogels were processed by spatiotemporal and temperature‐controlled gelation and freezing‐lyophilizaton process, followed by zero‐length crosslinking, using different molarities of reagents (EDC and NHS) and reaction media (100% PBS or 20/80% PBS/EtOH mixture) for variable time extensions (1–24 h). In this way, tuneable cryogels with gradient microporosity (from 100 µm to 1000 µm) were formed, being mainly influenced by crosslinkers' concentration and EtOH addition. Later affect the pore morphology (from round to ellipsoid), consequently modulating the steady‐state physiological swelling profile toward twice lower values (∼ 600%) comparing to stepwise swelling of in 100% PBS media crosslinked cryogels. While the presence of EtOH decelerate the crosslinking kinetic by retaining cryogels' microstructure formed during freezing, the 100% PBS and higher EDC molarity resulted in approximately 40% crosslinking degree, being expressed as a thermal resistance of cryogels up to approximately 73°C. Finally, the tuneable enzymatic resistance allow time‐dependent poly‐l‐Lysine (pL) release profile in up to month period. The processed GEL cryogels have potential in broad range biomedical applications, especially as sustainable, protein‐based drug delivery systems. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1119–1130, 2015.