bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHRISTINA ROSSETTI AND THE ECONOMICS OF PUBLICATION: MACMILLAN'S MAGAZINE, “A BIRTHDAY,” AND BEYOND
Authors: Van Remoortel Marianne 
Published: October 2013

Impelled to seek relief from a “peccant chest” (L233) at the seaside, Christina Rossetti travelled to Hastings in December 1864, taking a carefully wrapped bundle of unfinished manuscript poetry with her. Throughout the winter until the following March, a series of letters to Cheyne Walk kept her brother Dante Gabriel abreast not only of her gradual recovery, but also of her efforts to complete her second book of poetry, two years after she had made a successful debut with Goblin Market. Shortly after her arrival, Rossetti reported that she was struggling to finish “The Prince's Progress,” the long narrative poem that was to lend its title to the new volume:
[M]y Alchemist still shivers in the blank of mere possibility: but I have so far overcome my feelings and disregarded my nerves as to unloose the Prince, so that string wrapping paper may no longer bar his “progress.” Also I have computed pages of the altogether-unexceptionable, and find that they exceed 120: this cheers though not inebriates. Amongst your ousted I recognize sundry of my own favourites, which perhaps I may adroitly re-insert when publishing day comes round. . . . Meanwhile I have sent 3 (I hope) pot-boilers to Mac's Mag. (L233)
In the past few decades, Rossetti's lifelong effort to see what critics have variously called “the divine spiritual essence of material beauty” (Harrison 56), the “moral and spiritual significance in physical signs” (Arseneau 279), and “the spiritual in the sensuous, the numinous in the material” (Kooistra, Illustration 38) has become a mainstay of Rossetti scholarship. This excerpt from her correspondence, in contrast, reveals her equally profound preoccupation with the materiality and economics of writing. Issues of textual ownership, authorial control, and literary marketability confronted Rossetti in the 1860s as her financial situation forced her to balance book publication with regular contributions to the periodical press, notably Macmillan's Magazine, the magazine owned by Rossetti's publisher Macmillan and Co., which carried more of her poetry than any other British periodical in the nineteenth century. These issues extended beyond Rossetti's personal dealings with Macmillan, however, shaping the material and interpretive consumption of her work throughout her career. This arc may be seen in the publication and adaptation history of one of her most popular poems, “A Birthday,” from its first appearance in Macmillan's Magazine in 1861 until her death. Over time, the poem underwent various types of mediation: reprints in gift books and poetry anthologies, musical adaptation, vocal performance, and quotations in fictional works. Finally, her reaction to the three parodies of her poems published in an 1888 comic magazine – particularly to “An Unexpected Pleasure,” the parody of “A Birthday” – demonstrate her perspective on the increased commodity value of the original poem.
Effects of Community-Based Prevention on Alcohol Consumption in Adolescents
Authors: Kraus Ludwig , Hannemann Tessa-Virginia , Piontek Daniela , Awolin Mareike 
Published: October 2013

Aims: The present paper aims at evaluating the effectiveness of the community-based substance use prevention program “Wegschauen ist keine Lösung”. Methods: Communities of the district of Karlsruhe were divided into a group with high (HIG) and low (LIG) program implementation fidelity. In 2011, a school survey was conducted among 892 adolescents in grades 9 and 10 of regular schools in the district of Karlsruhe. The Bavarian sample of the 2011 European School Survey Project on Alcohol and other Drugs (ESPAD) was used as external comparison group (n=1635). Results: Only few differences were found between HIG and LIG with regard to alcohol consumption and negative consequences. Compared to the external ESPAD comparison group, students in Karlsruhe showed lower 30-day prevalence of alcohol use (66.0 vs. 80.5 %), lower consumption quantity (17.17 vs. 34.91 grams of ethanol per drinking day) and lower frequency of use (0.75 vs. 1.21 days within the last week). Conclusions: Considering restrictions of the limited study design there are indications of possible positive effects of the project “Wegschauen ist keine Lösung”. However, for methodological sound evaluations of community-based prevention programs pre-post studies with clearly defined control conditions are needed.
Development of a mouse model mimicking key aspects of a viral asthma exacerbation
Authors: Clarke Deborah L. , Davis Nicola H. E. , Majithiya Jayesh B. , Piper Sian C. , Lewis Arthur , Sleeman Matthew A. , Corkill Dominic J. , May Richard D. 
Published: October 2013

Viral respiratory tract infections are known triggers of asthma exacerbations in both adults and children. The current standard of care, inhaled CS (corticosteroids) and LABAs (long-acting β2-adrenoceptor agonists), fails to prevent the loss of control that manifests as an exacerbation. In order to better understand the mechanisms underlying viral asthma exacerbations we established an in vivo model using the clinically relevant aeroallergen HDM (house dust mite) and the viral mimetic/TLR3 (Toll-like receptor 3) agonist poly(I:C). Poly(I:C) alone induced a similar neutrophilic inflammatory profile in the BAL (bronchoalveolar lavage) to that of HRV1b (human rhinovirus 1b) alone, accompanied by both elevated BAL KC (keratinocyte-derived chemokine) and IL-1β (interleukin-1β). When mice allergic to HDM were also challenged with poly(I:C) the neutrophilic inflammatory profile was exacerbated. Increased CD8+ T-cell numbers, increased CD4+ and CD8+ cell activation and elevated KC and IL-1β were observed. No increases in Th2 cytokines or the eosinophil chemoattractant CCL11 [chemokine (C-C motif) ligand 11], above those induced by HDM alone, were observed. The poly(I:C)-exacerbated neutrophilia did not translate into changes in AHR (airways hyper-responsiveness), indicating that in this model inflammation and AHR are two mechanistically independent events. To test the clinical relevance of this model CS sensitivity was assessed using prednisone, a synthetic oral CS used to manage exacerbations in asthmatic patients already on maximal doses of inhaled CS. The increased neutrophils, and accompanying cytokines/chemokines KC and IL-1β induced by poly(I:C) challenge of HDM-sensitized and challenged mice were insensitive to oral prednisone therapy. In summary we have described a CS-resistant mouse model mimicking the key aspects of viral asthma exacerbation using the clinically relevant aeroallergen HDM and the viral mimic poly(I:C). This model may provide better understanding of disease mechanisms underlying viral exacerbations and could be used to build early confidence in novel therapeutic axes targeting viral asthma exacerbations in Th2 asthmatics.
Surface acoustic wave in temperature compensated NdCa4O(BO3)3 crystal
Authors: Brzozowski E. , Soluch W. 
Published: October 2013

A two‐port synchronous resonator was used for measurements of surface acoustic wave (SAW) parameters in the Y‐plane of NdCa4O(BO3)3 crystal. For YX–5°, YX and YX + 5° orientations, the SAW phase velocity under free surface, electromechanical coupling coefficient, second‐order temperature coefficient of frequency and turnover temperature (TO) of about 3481, 3502 and 3503 m/s; 0.68, 0.63 and 0.6%; −37, −32 and −70 ppb/°C2 and 80, 25 and −35 °C, respectively, were obtained. The crystal was assessed as attractive in SAW applications due to temperature compensation and high electromechanical coupling coefficient.
Mouse model phenotypes provide information about human drug targets
Authors: Hoehndorf Robert , Hiebert Tanya , Hardy Nigel W. , Schofield Paul N. , Gkoutos Georgios V. , Dumontier Michel 
Published: October 2013

Abstract
Motivation: Methods for computational drug target identification use information from diverse information sources to predict or prioritize drug targets for known drugs. One set of resources that has been relatively neglected for drug repurposing is animal model phenotype.
Results: We investigate the use of mouse model phenotypes for drug target identification. To achieve this goal, we first integrate mouse model phenotypes and drug effects, and then systematically compare the phenotypic similarity between mouse models and drug effect profiles. We find a high similarity between phenotypes resulting from loss-of-function mutations and drug effects resulting from the inhibition of a protein through a drug action, and demonstrate how this approach can be used to suggest candidate drug targets.
Availability and implementation: Analysis code and supplementary data files are available on the project Web site at https://drugeffects.googlecode.com.
Contact: leechuck@leechuck.de or roh25@aber.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
Migration and Wage Effects of Taxing Top Earners: Evidence from the Foreigners’ Tax Scheme in Denmark
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Authors: Kleven Henrik Jacobsen , Landais Camille , Saez Emmanuel , Schultz Esben 
Published: October 2013

Abstract
This article analyzes the effects of income taxation on the international migration and earnings of top earners using a Danish preferential foreigner tax scheme and population-wide Danish administrative data. This scheme, introduced in 1991, allows new immigrants with high earnings to be taxed at a preferential flat rate for a duration of three years. We obtain two main results. First, the scheme has doubled the number of highly paid foreigners in Denmark relative to slightly less paid—and therefore ineligible—foreigners. This translates into a very large elasticity of migration with respect to 1 minus the average tax rate on foreigners, between 1.5 and 2. Second, we find compelling evidence of a negative effect of the scheme-induced reduction in the average tax rate on pretax earnings of foreign migrants at the individual level. This finding can be rationalized by a matching frictions model with wage bargaining where there is a gap between pay and marginal productivity.
Molecular determinants of orexin receptor‐arrestin‐ubiquitin complex formation
Authors: Jaeger Werner C , Seeber Ruth M , Eidne Karin A , Pfleger Kevin D G 
Published: October 2013

Background and PurposeThe orexin system regulates a multitude of key physiological processes, particularly involving maintenance of metabolic homeostasis. Consequently, there is considerable potential for pharmaceutical development for the treatment of disorders from narcolepsy to metabolic syndrome. It acts through the hormonal activity of two endogenous peptides, orexin A binding to orexin receptors 1 and 2 (OX1 and OX2) with similar affinity, and orexin B binding to OX2 with higher affinity than OX1 receptors. We have previously revealed data differentiating orexin receptor subtypes with respect to their relative stability in forming orexin receptor‐arrestin‐ubiquitin complexes measured by BRET. Recycling and cellular signalling distinctions were also observed. Here, we have investigated, using BRET, the molecular determinants involved in providing OX2 receptors with greater β‐arrestin‐ubiquitin complex stability.Experimental ApproachThe contribution of the C‐terminal tail of the OX receptors was investigated by bulk substitution and site‐specific mutagenesis using BRET and inositol phosphate assays.Key ResultsReplacement of the OX1 receptor C‐terminus with that of the OX2 receptor did not result in the expected gain of function, indicating a role for intracellular domain configuration in addition to primary structure. Furthermore, two out of the three putative serine/threonine clusters in the C‐terminus were found to be involved in OX2 receptor‐β‐arrestin‐ubiquitin complex formation.Conclusions and ImplicationsThis study provides fundamental insights into the molecular elements that influence receptor‐arrestin‐ubiquitin complex formation. Understanding how and why the orexin receptors can be functionally differentiated brings us closer to exploiting these receptors as drug targets.Linked ArticlesThis article is part of a themed section on Orexin Receptors. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐2
A multicentre comparison of a fast track or conventional postoperative protocol following laparoscopic or open elective surgery for colorectal cancer surgery
Authors: Esteban F. , Cerdan F. J. , Garcia‐Alonso M. , Sanz‐Lopez R. , Arroyo A. , Ramirez J. M. , Moreno C. , Morales R. , Navarro A. , Fuentes M. 
Published: October 2013

AbstractAimThe introduction of multimodal or fast track (FT) rehabilitation and laparoscopy in colorectal surgery has improved patient recovery and shortened hospital stay (HS). This study aimed to determine the influence of laparoscopic or open surgery on the postoperative recovery of colorectal cancer patients having a conventional care (CC) or FT protocol in the postoperative period.MethodA multicentre prospective study was controlled with a retrospective group. The prospective group included 300 patients having elective colorectal resection for cancer. The retrospective control group included 201 patients with the same characteristics who were treated before the introduction of the programme. The patients were divided into four groups including laparoscopy + FT, open surgery + FT, laparoscopy + CC, and open surgery + CC. The primary end‐points were HS and morbidity. Secondary end‐points included mortality and reoperation rates.ResultsThe overall median HS was 7 days. The median HS for laparoscopy + FT was 5 days, open + FT 6 days, laparoscopy + CC 9 days and open + CC 10 days (P < 0.001). In the regression model the laparoscopy + FT group had the greatest reduction in HS (P < 0.001). A significant reduction in HS was observed in the laparoscopy + FT group compared with laparoscopy + CC (P < 0.001). The overall patient morbidity was 30.6%. The logistic regression model adjusted for propensity score showed no statistically significant differences between the study groups regarding all other end‐points.ConclusionColorectal cancer patients who underwent laparoscopic surgery within a multimodal rehabilitation protocol experienced the shortest HS and the lowest morbidity.
Haemophilia Joint Health Score in healthy adults playing sports
Authors: Sluiter D. , Foppen W. , de Kleijn P. , Fischer K. 
Published: October 2013

SummaryTo evaluate outcome of prophylactic clotting factor replacement in children with haemophilia, the Haemophilia Joint Health Score (HJHS) was developed aiming at scoring early joint changes in children aged 4–18. The HJHS has been used for adults on long‐term prophylaxis but interpretation of small changes remains difficult. Some changes in these patients may be due to sports‐related injuries. Evaluation of HJHS score in healthy adults playing sports could improve the interpretation of this score in haemophilic patients. The aim of this study was to evaluate the HJHS scores in a cohort of young, healthy men participating in sports. Concomitant with a project collecting MRI images of ankles and knees in normal young adults, HJHS scores were assessed in 30 healthy men aged 18–26, participating in sports one to three times per week. One physiotherapist assessed their clinical function using the HJHS 2.1. History of joint injuries was documented. MRI images were scored by a single radiologist, using the International Prophylaxis Study Group additive MRI score. Median age of the study group was 24.3 years (range 19.0–26.4) and median frequency of sports activities was three times per week (range 1–4). Six joints (five knees, one ankle) had a history of sports‐related injury. The median overall HJHS score was 0 out of 124 (range 0–3), with 60% of subjects showing no abnormalities on HJHS. All joints were normal on MRI. These results suggest that frequent sports participation and related injuries are not related with abnormalities in HJHS scores.
Interleukin‐17F single‐nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy
Authors: Chaitanya V. S. , Jadhav R. S. , Lavania M. , Singh M. , Valluri V. , Sengupta U. 
Published: October 2013

SummaryThe objective of this study was to investigate the association, if any, between the interleukin‐17F (7488T>C) (rs763780) polymorphism and susceptibility to leprosy and to elucidate the relationship between IL‐17F genotypes and clinical profile of the disease. DNA was extracted from the peripheral venous blood of leprosy cases (n = 140), which were classified as per WHO classification into paucibacillary (PB) (n = 53) and multibacillary (MB) (n = 87) categories and healthy controls (n = 84) without any signs and symptoms of leprosy. The IL‐17F (7488 T/C) polymorphism was genotyped using amplification refractory mutation system – polymerase chain reaction (Allele‐specific amplification). In both PB and MB categories of leprosy cases, the homozygous TT genotype frequency was significantly higher than that of the healthy controls (78.70% vs. 29.76%, P < 0.05). The heterozygous TC genotype was higher in the controls than in the leprosy cases (57.14% vs. 17.68%, P < 0.05). TT genotype was more associated with the type 1 reactional states and tuberculoid/borderline tuberculoid groups in leprosy than the TC genotype. This study reveals that the IL‐17F (7488T>C) single‐nucleotide polymorphism is associated with susceptibility to leprosy and polymorphism confers decrease in risk of contracting leprosy in the north Indian cohort.
Opposing effects of pro‐ and anti‐inflammatory cytokine gene polymorphisms on the risk for breast cancer in western Indian women: a pilot study
Authors: Joshi N. N. , Bhat S. , Hake S. , Kale M. , Kannan S. 
Published: October 2013

AbstractIn an earlier study, the genotypes associated with higher level of transforming growth factor‐β1 (TGF‐β1) were found to reduce the risk for breast cancer in western Indian women. This observation implied that gene polymorphisms affecting the levels of pro‐ and anti‐inflammatory cytokines may influence the risk for breast cancer in this population. Hence, we performed genotyping for three more functional single‐nucleotide polymorphisms (SNPs) responsible for variations in the levels of cytokines associated with inflammation. To that effect, polymorphisms in genes coding for IL‐4 (IL‐4 C‐590T; rs2243250), IFN‐γ (IFN‐G A + 874T; rs2430561) and MCP‐1 (MCP‐1 A‐2578G; rs1024611) were examined in premenopausal, healthy women (N = 239) and patients with breast cancer (N = 182) from western India. In carriers of the IL‐4*590T allele, a reduced risk for the disease (dominant model; OR = 0.61, 95% CI 0.37–0.98) was seen similar to that seen in TGF‐B1*10C carriers. An opposite trend was observed with respect to the alleles associated with higher expression of MCP‐1 or IFN‐γ. In individuals positive for three or more alleles associated with higher levels of either pro‐ or anti‐inflammatory cytokines, an additive effect on the modulation of risk for the disease was evident (for TGF‐B1 & IL‐4, OR = 0.33, 95% CI 0.12–0.87; for IFN‐G & MCP‐1, OR = 2.29, 95% CI 0.95–5.51). In the context of contrasting observations in other populations, these results indicate a significant contribution of anti‐inflammatory genotypes in the modulation of risk for breast cancer in western Indian women.
Immunodetection of a brown planthopper (Nilaparvata lugens Stål) salivary catalase‐like protein into tissues of rice, Oryza sativa
Authors: Petrova A. , Smith C. M. 
Published: October 2013

AbstractSaliva plays an important role in host plant–phloem‐feeding insect molecular interactions. To better elucidate the role of insect saliva, a series of experiments were conducted to establish if catalase from the salivary glands of the brown planthopper (BPH; Nilaparvata lugens Stål) was secreted into rice host plant tissue during feeding. Catalase is the main enzyme that decomposes hydrogen peroxide (H2O2) at high concentrations. H2O2 is a part of the free radicals system that mediates important physiological roles including signalling and defence. Previous studies have suggested that H2O2 is involved in the rice endogenous response to BPH feeding. If, the BPH secretes catalase into host plant tissue this will counter the effects of H2O2, from detoxification to interfering with plant signalling and defence mechanisms. When BPHs were fed on a hopper‐resistant rice variety for 24 h, catalase activity in the salivary glands increased 3.5‐fold compared with hoppers fed on a susceptible rice variety. Further supporting evidence of the effects of BPH catalase was demonstrated by immunodetection analyses where results from two independent sources: BPH‐infested rice tissue and BPH‐probed artificial diets, suggest that the BPH secretes catalase‐like protein during feeding. The possible physiological roles of BPH‐secreted catalase are discussed.
Impact of a compulsory final year medical student curriculum on junior doctor prescribing
Authors: Thomas J. S. , Koo M. , Shakib S. , Wu J. , Khanal S. 
Published: October 2013

AbstractBackgroundAttendance at face‐to‐face sessions and completion of online components of the National Prescribing Curriculum was made compulsory for final year medical students at the University of Adelaide in 2010.AimsTo determine the impact of a compulsory prescribing curriculum for final year medical students on their prescribing competencies at the start of clinical practice. Graduates' attitudes to their medical school training in prescribing were also surveyed.MethodsTwo cohorts of medical graduates from the University of Adelaide who commenced medical practice in 2010 and 2011 were required to complete a prescribing task using the National Inpatient Medication Chart (NIMC) at orientation and after 6 months of clinical practice. The main outcome measure was a performance in a scenario‐based prescribing test, as determined by test scores and overall safety of prescriptions at orientation and 6 months of clinical practice.ResultsThere was a small difference in the average total score for the prescribing task between the 2010 and 2011 cohorts at orientation (P = 0.0007). The 2011 cohort had a higher number of safer charts at commencement of practice. We found no difference between the 2010 and 2011 cohorts in attitudes towards their undergraduate pharmacology education, and new graduates feel poorly prepared.ConclusionMedical graduates who are required to complete a practically oriented prescribing curriculum in final year perform slightly better on a prescribing assessment at commencement of practice. More work on preparing graduates for this complex task before graduation is needed.