bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fostering community discussions and building a toolkit for mental health and wellness in STEM
Authors: Williams Danielle R. , Duncan D’Anne , Rice Mallory M. , Sanchez Erica L. 
Published: August 2024

ABSTRACT

Mental health interventions can help mitigate the unique challenges that individuals in Science, Technology, Engineering, and Mathematics (STEM) face as they navigate these disciplines. We developed the “Mental Health and Wellness: Our Community and our Identity in STEM” workshop, which emphasizes leveraging our STEM community and promoting self-compassion, to foster a conversation among members of the STEM community on how to support mental health and wellness. This interactive workshop begins with a short lecture to define mental health and wellness and introduce evidence-based methods to increase self-compassion. Participants, who are often from diverse backgrounds and various career stages, then explore case studies that highlight experiences related to mental health across STEM career stages. Pre- and post-assessments of workshop participants suggest that participants had positive shifts in their ability to show compassion toward themselves as well as an increased comfort in discussing mental health within their STEM community. This workshop not only provided participants with practical tools and insights but also cultivated a supportive environment, underscoring the importance of mental health awareness and collective well-being within STEM fields. In this paper, we share tips on how this workshop was executed and lessons we have learned from our years of sharing similar workshops in the broader STEM community. We hope this paper serves as a valuable guide for potential facilitators to initiate conversations about mental health and wellness in their respective STEM spaces.
NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors
Authors: Nakagawara Kensuke , Ando Makoto , Srirat Tanakorn , Mise-Omata Setsuko , Hayakawa Taeko , Ito Minako , Fukunaga Koichi , Yoshimura Akihiko 
Published: August 2024

BackgroundAntitumor effect of chimeric antigen receptor (CAR)-T cells against solid tumors is limited due to various factors, such as low infiltration rate, poor expansion capacity, and exhaustion of T cells within the tumor. NR4A transcription factors have been shown to play important roles in T-cell exhaustion in mice. However, the precise contribution of each NR4a factor to human T-cell differentiation remains to be clarified.MethodsIn this study, we deleted NR4A family factors,NR4A1,NR4A2, and NR4A3,in human CAR-T cells recognizing human epidermal growth factor receptor type 2 (HER2) by using the CRISPR/Cas9 system. We induced T-cell exhaustion in these cells in vitro through repeated co-culturing of CAR-T cells with Her2+A549 lung adenocarcinoma cells and evaluated cell surface markers such as memory and exhaustion phenotypes, proliferative capacity, cytokine production and metabolic activity. We validated the antitumor toxicity of NR4A1/2/3 triple knockout (TKO) CAR-T cells in vivo by transferring CAR-T cells into A549 tumor-bearing immunodeficient mice.ResultsHuman NR4A-TKO CAR-T cells were resistant against exhaustion induced by repeated antigen stimulation in vitro, and maintained higher tumor-killing activity both in vitro and in vivo compared with control CAR-T cells. A comparison of the effectiveness of NR4A single, double, and TKOs demonstrated that triple KO was the most effective in avoiding exhaustion. Furthermore, a strong enhancement of antitumor effects by NR4A TKO was also observed in T cells from various donors including aged persons. Mechanistically, NR4A TKO CAR-T cells showed enhanced mitochondrial oxidative phosphorylation, therefore could persist for longer periods within the tumors.ConclusionsNR4A factors regulate CAR-T cell persistence and stemness through mitochondrial gene expression, therefore NR4A is a highly promising target for the generation of superior CAR-T cells against solid tumors.
AAC Darby Canada Western Red Spring wheat
Authors: Kumar S. , Burt A. , Green D. , Humphreys G. , McCallum B. , Fetch T. , Menzies J. , Aboukhaddour R. , Henriquez M-A. 
Published: August 2024

AAC Darby (PT495) is an early maturing, high yielding, awned and hollow stemmed Canada Western Red Spring (CWRS) wheat ( Triticum aestivum L.) cultivar suited to the growing conditions in the northern Canadian Prairies. AAC Darby was higher yielding than all the check varieties in the Parkland Wheat Cooperative (Park C) registration trials (2018–2020). AAC Darby was 6% higher yielding than Parata and 5% higher yielding than Carberry. AAC Darby matured 5 days earlier than Carberry and 1 day earlier than Parata. AAC Darby was similar in height to Glenn at 2 cm taller. The lodging score for AAC Darby was similar to the mean of the checks. The test weight of AAC Darby was similar to Carberry and the 1000-kernel weight was similar to Glenn and higher than Parata. AAC Darby had protein content only 0.07% lower than Carberry. AAC Darby expressed an intermediate resistant reaction to Fusarium head blight (FHB; Fusarium graminearum Schwabe). AAC Darby was moderately resistant to the prevalent races of stem rust ( Puccinia graminis Pers. f. sp. tritici Eriks. & E. Henn) and moderately susceptible to common bunt [ Tilletia caries (DC) Tul. & C. Tul.]. It was resistant to prevalent races of leaf rust ( Puccinia triticina Erikss.) and stripe rust ( Puccinia striiformis Westend). AAC Darby was resistant to orange wheat blossom midge (OBWM) ( Sitodiplosis mosellana Géhin). AAC Darby was registered under the CWRS class.
SYMPTOMATIC LATERAL DISCOID MENISCUS IN CHILDREN: A SYSTEMATIC LITERATURE REVIEW AND RETROSPECTIVE STUDY OF 32 CASES
Authors: Megremis Panos K. , Megremis Orestis P. 
Published: August 2024

A disk-shaped meniscus is a commonly known alternative to the C-shaped meniscus, which is defined by a larger-than-normal meniscus body. However, the enlarged meniscus has a severe disadvantage, which is the increase in shearing forces exerted on it, which can lead to a tear in its body. The Wrisberg form of discoid lateral meniscus is a rare abnormality. The absence of the posterior meniscotibial ligament results in an excessive range of movement and instability of the meniscus, with only its meniscofemoral ligament (Wrisberg’s ligament) remaining intact and attached to the posterior horn of the meniscus. Additionally, a Wrisberg variant can exhibit a significant disorder in its microstructure due to an abnormal collagen network, mucosal disintegration, and a lack of vascularity. This study includes 32 skeletally immature patients who came to our institution with symptomatic discoid lateral meniscus. The initial evaluation of every knee included magnetic resonance imaging (MRI), followed by arthroscopy. MRI enables the classification of discoid meniscus based on meniscal morphology, stability or instability, meniscal intrasubstance degradation, and the occurrence of meniscal rupture. The discoid meniscus was reshaped, excising the hypertrophied central portion of the meniscus. The International Knee Documentation Committee (IKDC) system, which is an online system for the evaluation of knee function, was utilized. Twenty-four discoid menisci were assessed as being stable and having a tear in their body. Eight discoid menisci were determined to be unstable (Wrisberg variant) with degeneration within their substance but no meniscus tear. At surgery, the mean age of the patients was 11.81+/−2.62 years (range 5–14 years). The average follow-up was 3.71+/−0.92 years (range, 3–6). The mean preoperative IKDC score was 44.71+/−14.42 (range, 21–57) points. Postoperatively, the mean IKDC score was 81.56+/−1.70 (range, 79–84) points. The two-tailed [Formula: see text]-value was < 0.0001. The assumption that MRI assessment is essential not only for detecting the Wrisberg alternate but also for uncovering possible meniscal disintegration and intra-substance alterations that are not usually observed through arthroscopy is supported by our data.
Artificial Intelligence-Powered Spatial Analysis of Tumor-Infiltrating Lymphocytes as a Potential Biomarker for Immune Checkpoint Inhibitors in Patients with Biliary Tract Cancer
Authors: Bang Yeong Hak , Lee Choong-kun , Bang Kyunghye , Kim Hyung-Don , Kim Kyu-pyo , Jeong Jae Ho , Park Inkeun , Ryoo Baek-Yeol , Lee Dong Ki , Choi Hye Jin , Chung Taek , Jeon Seung Hyuck , Shin Eui-Cheol , Oum Chiyoon , Kim Seulki , Lim Yoojoo , Park Gahee , Ahn Chang Ho , Lee Taebum , Finn Richard S. , Ock Chan-Young , Shin Jinho , Yoo Changhoon 
Published: August 2024

Abstract

Purpose:
Recently, anti-programmed cell death-1/anti-programmed cell death ligand-1 (anti-PD1/L1) immunotherapy has been demonstrated for its efficacy when combined with cytotoxic chemotherapy in randomized phase 3 trials for advanced biliary tract cancer (BTC). However, no biomarker predictive of benefit has been established for anti-PD1/L1 in BTC. Here, we evaluated tumor-infiltrating lymphocytes (TIL) using artificial intelligence-powered immune phenotype (AI-IP) analysis in advanced BTC treated with anti-PD1.

Experimental Design:
Pretreatment hematoxylin and eosin (H&E)–stained whole-slide images from 339 patients with advanced BTC who received anti-PD1 as second-line treatment or beyond, were employed for AI-IP analysis and correlative analysis between AI-IP and efficacy outcomes with anti-PD1. Next, data and images of the BTC cohort from The Cancer Genome Atlas (TCGA) were additionally analyzed to evaluate the transcriptomic and mutational characteristics of various AI-IP in BTC.

Results:
Overall, AI-IP were classified as inflamed [high intratumoral TIL (iTIL)] in 40 patients (11.8%), immune-excluded (low iTIL and high stromal TIL) in 167 patients (49.3%), and immune-desert (low TIL overall) in 132 patients (38.9%). The inflamed IP group showed a substantially higher overall response rate compared with the noninflamed IP groups (27.5% vs. 7.7%, P &lt; 0.001). Median overall survival and progression-free survival were significantly longer in the inflamed IP group than in the noninflamed IP group (OS, 12.6 vs. 5.1 months; P = 0.002; PFS, 4.5 vs. 1.9 months; P &lt; 0.001). In the TCGA cohort analysis, the inflamed IP showed increased cytolytic activity scores and IFNγ signature compared with the noninflamed IP.

Conclusions:
AI-IP based on spatial TIL analysis was effective in predicting the efficacy outcomes in patients with BTC treated with anti-PD1 therapy. Further validation is necessary in the context of anti-PD1/L1 plus gemcitabine–cisplatin.
Central Hemodynamics in African American Women: Examining the Role of Superwoman Schema Endorsement
Authors: Martin Zachary T. , Fields Nicole D. , Erving Christy L. , Udaipuria Shivika , Moore Reneé H. , Blevins Kennedy M. , Murden Raphiel J. , Booker Bianca , Culler LaKeia , Swanson Seegar , Goodson Jaylah , Barinas‐Mitchell Emma , Quyyumi Arshed A. , Vaccarino Viola , Lewis Tené T. 
Published: August 2024

Background
African American women bear a disproportionate burden of cardiovascular diseases, potentially due to altered central hemodynamics. Racism and sexism often lead to African American women taking on numerous caretaking roles and overall increases their use of the Strong Black Woman (ie, Superwoman) mindset, which may have negative health consequences. We hypothesized that endorsing the Superwoman role and its Obligation to Help Others dimension would be associated with a deleterious central hemodynamics profile in African American women.

Methods and Results
Using cross‐sectional data, we examined central systolic blood pressure (mm Hg; n=408), augmentation index (percentage, adjusted for height and heart rate; n=408), and pulse wave velocity (m/s; n=368) in African American women aged 30 to 46 years. The Giscombe Superwoman Schema (SWS) questionnaire assessed endorsement of Overall SWS (range, 0–105) and SWS–Obligation to Help Others (range, 0–3). Multiple linear regression modeled associations between Overall SWS (10‐unit increments) and SWS–Obligation to Help Others (1‐unit increments) and central hemodynamics while adjusting for pertinent sociodemographic, clinical, and psychosocial factors. In fully adjusted models, central systolic blood pressure was significantly associated with Overall SWS (β=0.83 [95% CI, 0.19–1.47]) and SWS–Obligation to Help Others (β=2.03 [95% CI, 0.39–3.67]). Augmentation index was associated with Overall SWS (β=0.66 [95% CI, 0.02–1.30]) and SWS–Obligation to Help Others (β=2.21 [95% CI, 0.58–3.84]). Significant associations were not observed between pulse wave velocity and SWS.

Conclusions
Greater endorsement of the Superwoman role and prioritizing caregiving over self‐care were associated with higher central systolic blood pressure and augmentation index, which may contribute to adverse cardiovascular health among African American women.
Reproductive traits of Gnathophylloides mineri Schmitt, 1933, a minute ectosymbiotic shrimp associated with the sea urchin Tripneustes ventricosus
Authors: Wehrtmann Ingo S. , Vásquez-Fallas Fiorella 
Published: August 2024

Abstract
Numerous studies on the reproduction of decapods have revealed that the female energy investment in embryo production is generally around 10% of the female weight. In decapods living together with other organisms, however, the reproductive output (RO) may be substantially higher. Here we tested the hypothesis that decapods living in association with other organisms allocate more energy in embryo production than free-living ones. We studied the shrimp Gnathophylloides mineri, which lives among the spines of the sea urchin Tripneustes ventricosus. Shrimps were collected between October 2011 and April 2013 along the southern Caribbean coast of Costa Rica. A total of 45 ovigerous females were analyzed; female size ranged from 1.44 to 2.14 mm carapace length. Females carried on average 37 ± 16 SD embryos. The embryo volume increased during the incubation period by 200% (from 0.04 ± 0.01 to 0.08 ± 0.01 mm3, mean ± SD). The RO was not related to female size, and comprised on average 27.5 ± 16.0 SD % of the dry weight of the females. In summary, G. mineri produces few and small embryos, but these embryos are relatively large when compared to similar-sized caridean species. Moreover, RO of this ectosymbiotic species was higher than in free-living species, but lower than in endosymbiotic decapods. These results support the hypothesis that energy investment in embryo production of decapods increases with the level of protection associated with the symbiosis.
The genus Geosesarma De Man, 1892 (Decapoda, Brachyura, Sesarmidae) from Sulawesi, Indonesia
Authors: Shahdadi Adnan , Ng Peter K. L. 
Published: August 2024

Abstract
Three species of Geosesarma: G. celebense, G. leprosum and G. clavicrure have been previously described from the Indonesian island of Sulawesi. To evaluate their identities, we examined type material of the three species, and they are re-described and illustrated. A short segment of 229 bp of COX1 gene from the Sulawesian Geosesarma was obtained (when available) and used for genetic comparisons. Our record of G. celebense from Selatan, South Sulawesi, and the genetic affinity between the type from North Sulawesi and the southern material indicates that G. celebense is well distributed throughout Sulawesi. The present study also describes a new species of Geosesarma from central Sulawesi. Geosesarma schubarti new species differs significantly from other Sulawesian Geosesarma in the morphology of the carapace, which is distinctly squarish in shape with a clear second anterolateral tooth. Genetic distances, using the segment of COX1 marker, showed all Sulawesian Geosesarma species, including the new one, are distant from each other. Our morphological comparisons also show that G. clavicrure is actually a junior subjective synonym of Bresedium brevipes; and the sequences of G. clavicrure grouped stably with B. brevipes in the 16S phylogenetic tree, and G. clavicrure therefore needs to be removed from the genus Geosesarma. As a consequence, with the new species, there remain three known species for Sulawesi (G. celebense, G. leprosum, G. schubarti), but based on currently available evidence it is considered likely that there exist additional species from this genus on the island.
New records of two deep-sea Periclimenes species (Decapoda, Caridea, Palaemonidae) from the North-East Atlantic
Authors: Fransen Charles H. J. M. 
Published: August 2024

Abstract
During the “Tydeman” CANCAP VII expedition to the Cape Verde Islands in 1986 and the “Tyro” MAURITANIA II Expedition to the Banque d’Arguin off the coast of Mauritania in 1988, several specimens belonging to two species within the genus Periclimenes were trawled from deep water constituting range extensions for both species. The specimens are here compared with previous descriptions, illustrated, and their distribution is discussed.
Reproductive biology of two species of semiterrestrial crabs of the genus Armases (Brachyura, Sesarmidae) living in sympatry in a southern Caribbean coastal stream
Authors: Moreno María T. , Montoya José V. , Quintero-Torres Enrique , Carmona-Suárez Carlos , López-Sánchez Beatriz 
Published: August 2024

Abstract
The reproductive biology of two sesarmid species, Armases americanum and A. roberti, was investigated for 12 months between 2012-2013 in the San Miguel stream, a coastal stream in the southern Caribbean. Sampling encompassed wet and dry season months. The two species are in general allopatrically distributed on islands and the mainland in the Caribbean Sea but were found living in sympatry in the sampled locality. For these two species living in sympatry, here we addressed the question whether there will be differences in their reproductive traits that would allow us to understand their coexistence. Reproductive parameters included sex ratio, maturity size, frequency of mature individuals, fecundity, embryo size, and reproductive output. We collected 1417 individuals (1188 A. americanum, 229 A. roberti). Populations were male-biased, but ratios were only significantly different from parity for A. americanum. Both species reached sexual maturity at similar sizes, but A. americanum females matured at smaller sizes than males (♀ 12.68 ± 0.50 mm, ♂ 13.26 ± 0.90 mm), producing numerous small embryos (23 003 ± 13 451 embryos; 0.0208 ± 0.0048 mm3), while A. roberti females matured at larger sizes than males (♀ 14.38 ± 1.74 mm, ♂ 13.19 ± 0.73 mm), and producing fewer and larger embryos (17 948 ± 11 738 embryos; 0.0363 ± 0.0104 mm3). Fecundity did not correlate with female size. Reproductive output was slightly higher for A. roberti when compared to A. americanum (9.1 vs. 7.5%). Fecundity, embryo size, and reproductive output ranged within reported values for other American sesarmids. Our results revealed that both species presented distinct reproductive strategies, underscoring the significance of species-specific differences in comprehending their coexistence. Future studies involving allopatric populations of both species will help to determine whether differences in their reproductive strategies are less pronounced when compared to the sympatric populations examined here.
Liomera schubarti, a new species of xanthid crab (Brachyura, Xanthidae) from the Persian Gulf, northwestern Indian Ocean
Authors: Fahimi Neda , Naderloo Reza 
Published: August 2024

Abstract
This taxonomic study describes Liomera schubarti n. sp., a newly discovered xanthid crab inhabiting live coral in the Persian Gulf. The new species shares a general resemblance with four other species of this genus, L. bella, L. margaritata, L. rugata and L. yaldwyni, particularly in carapace morphology, but it can be distinguished by the fusion of carapace areolets, specific pattern of granules on the outer surface of the chela and the unique structure of the male first gonopod. This contribution enriches our understanding of the xanthid crab diversity in the Persian Gulf.
Publications by, taxa named by, and taxa named in honour of Christoph D. Schubart
Authors: Cuesta Jose A. , Wehrtmann Ingo S. , Thiel Martin 
Published: August 2024

Abstract
In this contribution we have compiled the papers published by Christoph D. Schubart, the species named by him and his coauthors, and the species named in his honour. At the date of compiling these lists, Christoph has published 205 papers, many with his students as first authors. More than 50 taxa, all decapod crustaceans, have been named by Christoph, and his colleagues have named more than 15 taxa in his honour. His career has been characterized by collaborations, and we expect these lists to grow during the coming years, when his colleagues continue to conclude the studies Christoph had initiated before his tragic death.
The Crucified People: the Divinized African State and the De-divinized African People
Authors: Olokunboro Fidelis A. 
Published: August 2024

Abstract
How are we to talk about a God who is revealed as love in a situation characterized by poverty and oppression, especially when such poverty is debilitating and vulgarizing? In addressing this question, this article will emphasize the essentiality of economic and anthropological categories in African political theology. It will proceed to explore the reality of the divinization of the African state as the trigger of African poverty. It will discuss the reality of African poverty as the de-subjectivation of African people, and the crucifixion theology of instrumentalized poverty in Africa. Finally, it will propose a theo-anthropological framework as the theo-political public thinking in Africa that will de-divinize the African state, divinize and subjectify the African person.
On Critiquing Christian Nationalism: Two Recent Books on the Perils of Christian Nationalism
Authors: Bird Michael F. 
Published: August 2024

Abstract
This article engages in a concerted review and interaction with two recent books about Christian nationalism by David Gushee and Nilay Saiya. It offers affirmation and critique with respect to their warnings about the dangers of such for Christian political witness. Each book is evaluated pro and con for the validity and accuracy of its critique of Christian nationalism: alternative options are also canvassed. The essay closes with six theses, inspired by Gushee and Saiya, for a Christian political theology today.
Derogations in Exchange of Increased Responsibility: How Can This Fix the Broken Promise for More Solidarity in the EU?
Authors: Apatzidou Vasiliki 
Published: August 2024

Abstract
The 2020 EU Pact on Migration and Asylum introduced a series of legal texts aimed at reforming the existing EU asylum policy. Following years of challenging negotiations, an agreement on the Pact was reached in December 2023 with all the texts published in the Official Journal of the EU in May 2024. This article critically discusses some provisions of three key texts within the Pact: the Asylum Procedures Regulation (APR), the Crisis Regulation, and the Asylum and Migration Management Regulation (AMMR). The aim is to uncover the strategic employment of derogations and exceptions to compensate external border states for their heightened responsibilities, particularly in situations of migratory pressure. The article also explores the impact of newly introduced concepts and measures, such as the ‘non-entry’ fiction and the concept of ‘adequate capacity’ in border procedures, as well as derogatory provisions in ‘crisis’ and ‘instrumentalisation’ situations. It highlights how the agreed instruments, under the guise of presenting derogations as a form of ‘solidarity’, compromise the rights of asylum seekers and fail to effectively address the increased responsibility of states at the external borders. It further argues that these measures deviate from the goal of harmonisation within the Common European Asylum System (CEAS). The paper concludes by emphasising that the promise of achieving a fair and balanced asylum system in the EU remains unfulfilled, with an overreliance on derogations overshadowing genuine progress.