bluuebunny/crossref_metadata_2025_split huggingface dataset:
“There is soccer but we have to watch”: the embodied consequences of rhetorics of inclusion for South African children with cerebral palsy
Authors: Bantjes Jason , Swartz Leslie , Conchar Lauren , Derman Wayne 
Published: January 2015

ABSTRACTTwenty years after the advent of democracy in South Africa (SA), there have been some successes in the achievement of greater equality, access and inclusion for many persons with disabilities. The move towards inclusive education may, however, have had unanticipated embodied consequences for people positioned discursively as included, but who in fact may in some respects be further marginalised than they had been under apartheid. We describe ethnographic research conducted in a special needs school in SA to explore the lived experiences of children with cerebral palsy and their involvement in physical activity. Our study shows how inclusive educational practices in SA have impeded involvement in sport for some children with motor impairments because of resource limitations and other historic reasons. This paper raises important questions about the role of community psychology in recognising, naming and contributing to action around injustices, which may be hard to see but which can have profound effects on the lives and bodies of those who experience exclusion. Copyright © 2015 John Wiley & Sons, Ltd.
Power boosting factor determination in impulse postfix‐OFDM‐based positioning system
Authors: Zhou Biao , Jing Changqiang , Kim Youngok 
Published: January 2015

SummaryBased on recently introduced novel impulse postfix‐OFDM scheme, we proposed a joint time‐of‐arrival/angle‐of‐arrival positioning scheme, in which both channel estimation and positioning information can be realized by analyzing the channel impulse response estimated on an access point equipped with a uniform linear antenna array. However, the power boosting factor (PBF) determination of impulse postfix (IP) should be taken as an important issue, because a small PBF will result in imprecise channel estimation and deteriorate the communication quality, as well as positioning accuracy; in contrast, the huge power assignment on IP will lead to insufficient power allocated on date portion, when transmitted power is restricted, which also increases the system BER. In this paper, to obtain the optimal performance of both BER and positioning accuracy, we mathematically analyze the BER and positioning performance with increasing PBFs in the term of signal‐to‐noise ratio and confirm our assumption in the cases of quadrature phase‐shift keying and 16‐quadrature amplitude modulation, with computer simulation. The result applies that, as the PBF is increasing, the system BER is enhanced until PBF reaches 15 and starts deteriorating thereafter. According to the result, the decision criteria for determining PBF of IP should depend on practical preference of BER or positioning. Copyright © 2015 John Wiley & Sons, Ltd.
An efficient energy‐aware predictive clustering approach for vehicular ad hoc networks
Authors: Bali Rasmeet S. , Kumar Neeraj , Rodrigues Joel J.P.C. 
Published: January 2015

SummaryWith an emergence of information and communication technologies, there is an increase in the demands of providing safety and comfort to the passengers during their mobility on the road. These demands can be fulfilled by one of the most popular networks of its type—vehicular adhoc networks (VANETs). As vehicles in VANETs are constrained with respect to the available resources such as computation and storage, lot of energy is consumed to perform a number of complex operations, which may lead to the emission of harmful CO2 emission that effect the global warming system. Moreover, because of high velocity led by constant topological changes, it is a challenging task to maintain quality of service with respect to parameters such as high throughput, and minimum end‐to‐end delay. Hence, an intelligent approach is required to optimize the various complex operations in this environment, which may led to the minimum emission of CO2 and other gasses. To address these issues, this paper proposes an efficient energy‐aware predictive clustering scheme for vehicles. Efficient algorithms are designed for future mobility predictions and average variations of vehicles on the road. The algorithms estimate the clustering duration and total vehicles in the cluster. The performance of the designed algorithms is studied using extensive simulations by varying the number of vehicles and cluster durations in comparison with existing benchmarked scheme in the literature. The results obtained show that the proposed scheme is superior in comparison with the existing scheme of its category. Copyright © 2015 John Wiley & Sons, Ltd.
Risk factors for hyperkalaemia in a cohort of patients with newly diagnosed heart failure: a nested case–control study in UK general practice
Authors: Michel Alexander , Martín‐Pérez Mar , Ruigómez Ana , García Rodríguez Luis A. 
Published: January 2015

AimsThe aim of this study was to identify risk factors for hyperkalaemia in a cohort of patients with newly diagnosed heart failure in the UK.Methods and resultsA nested case–control study was conducted using data from The Health Improvement Network primary care database. A cohort of 19 194 patients aged 1–89 years between January 2000 and December 2005 with newly diagnosed heart failure was followed up and cases of hyperkalaemia identified. Cases were frequency matched to controls by age, sex, and calendar year, and information on demographics, co‐morbidities, co‐medications, and lifestyle factors was extracted from the database. Using unconditional logistic regression models, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to identify potential risk factors. In total, 2176 hyperkalaemia cases were identified over a mean follow‐up of 3.9 years. Significant risk factors for hyperkalaemia were: renal failure (OR 3.81; 95% CI 3.29–4.42), type II diabetes (OR 1.52; 95% CI 1.31–1.75), valvular heart disease (OR 1.28; 95% CI 1.06–1.54), and current use of potassium‐sparing diuretics (OR 3.01; 95% CI 2.61–3.48), ACE inhibitors (OR 1.70; 95% CI 1.41–2.04), trimethoprim (OR 2.82; 95% CI 1.88–4.23), non‐steroidal anti‐inflammatory drugs (OR 1.41; 95% CI 1.11–1.79), and several drug combinations. The risk was highest within the first month of medication use and decreased thereafter.ConclusionOur findings may help to better identify patients with heart failure most likely to benefit from careful monitoring of serum potassium levels. Particular vigilance is needed during the start of treatment with certain medications.
Dune deformation in a multi‐directional wind regime: White Sands Dune Field, New Mexico
Authors: Pedersen Anine , Kocurek Gary , Mohrig David , Smith Virginia 
Published: January 2015

AbstractAs with most dune fields, the White Sands Dune Field in New Mexico forms in a wind regime that is not unimodal. In this study, crescentic dune shape change (deformation) with migration at White Sands was explored in a time series of five LiDAR‐derived digital elevation models (DEMs) and compared to a record of wind direction and speed during the same period. For the study period of June 2007 to June 2010, 244 sand‐transporting wind events occurred and define a dominant wind mode from the SW and lesser modes from the NNW and SSE. Based upon difference maps and tracing of dune brinklines, overall dune behavior consists of crest‐normal migration to the NE, but also along‐crest migration of dune sinuosity and stoss superimposed dunes to the SE. The SW winds are transverse to dune orientations and cause most forward migration. The NNW winds cause along‐crest migration of dune sinuosity and stoss bedforms, as well as SE migration of NE‐trending dune terminations. The SSE winds cause ephemeral dune deformation, especially crestal slipface reversals. The dunes deform with migration because of differences in dune‐segment size, and differences in the lee‐face deposition rate as a function of the incidence angle between the wind direction and the local brinkline orientation. Each wind event deforms dune shape, this new shape then serves as the boundary condition for the next wind event. Shared incidence‐angle control on dune deformation and lee‐face stratification types allows for an idealized model for White Sands dunes. Copyright © 2015 John Wiley & Sons, Ltd.
This Ad is for You: Targeting and the Effect of Alcohol Advertising on Youth Drinking
Authors: Molloy Eamon 
Published: January 2015

AbstractEndogenous targeting of alcohol advertisements presents a challenge for empirically identifying a causal effect of advertising on drinking. Drinkers prefer a particular media; firms recognize this and target alcohol advertising at these media. This paper overcomes this challenge by utilizing novel data with detailed individual measures of media viewing and alcohol consumption and three separate empirical techniques, which represent significant improvements over previous methods. First, controls for the average audience characteristics of the media an individual views account for attributes of magazines and television programs alcohol firms may consider when deciding where to target advertising. A second specification directly controls for each television program and magazine a person views. The third method exploits variation in advertising exposure due to a 2003 change in an industry‐wide rule that governs where firms may advertise. Although the unconditional correlation between advertising and drinking by youth (ages 18–24) is strong, models that include simple controls for targeting imply, at most, a modest advertising effect. Although the coefficients are estimated less precisely, estimates with models including more rigorous controls for targeting indicate no significant effect of advertising on youth drinking. Copyright © 2015 John Wiley & Sons, Ltd.
Benefits and drawbacks of open partial horizontal laryngectomies, Part A: Early‐ to intermediate‐stage glottic carcinoma
Authors: Succo Giovanni , Crosetti Erika , Bertolin Andy , Lucioni Marco , Caracciolo Alessandra , Panetta Valentina , Sprio Andrea Elio , Berta Giovanni Nicolao , Rizzotto Giuseppe 
Published: January 2015

ABSTRACTBackgroundLaryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1–T2, and N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy is a function‐sparing surgical technique used to treat laryngeal SCC.MethodsWe retrospectively analyzed the clinical outcomes of 216 patients who underwent open partial horizontal laryngectomy for glottic cT2 laryngeal cancer.ResultsFive‐year overall survival (OS), disease‐specific survival (DFS), locoregional control, local control, laryngeal function preservation, and laryngectomy‐free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8%, and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery used.ConclusionAlthough TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, open partial horizontal laryngectomy offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space. © 2015 Wiley Periodicals, Inc. Head Neck 38: E333–E340, 2016
Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia‐telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma
Authors: Hsia Shih‐Min , Yu Cheng‐Chia , Shih Yin‐Hua , Yuanchien Chen Michael , Wang Tong‐Hong , Huang Yu‐Ting , Shieh Tzong‐Ming 
Published: January 2015

AbstractBackgroundIsoliquiritigenin (ISL), a natural compound extracted from licorice, has chemopreventive and antitumor activities. The purpose of this study was to investigate the anticancer effect of ISL on human oral squamous cell carcinoma (OSCC).MethodsThe anti‐OSCC effects of ISL were evaluated using the 3‐(4,5‐dimethylthiazol‐2‐yl)−2,5‐diphenyltetrazolium bromide test, flow cytometry, reverse transcription‐polymerase chain reaction, Western blotting, promoter activity, terminal deoxynucleotidyl transferase dUTP nick‐end labeling assay, malignant phenotype analysis, microRNA, and xenografting.ResultsISL induced OSCC cell cycle G2/M phase arrest, apoptosis, and DNA damage. However, the DNA repair‐associated ataxia telangiectasia mutated (ATM) and phospho‐ATM were downregulated, ATM mRNA remained unchanged, and the downstream signals were inhibited. ATM recovered when the caspase activity was blocked by Z‐DVED‐FMK. A low dose of ISL inhibited OSCC malignancy in vitro and reduced the tumor size in vivo.ConclusionATM was cleaved by ISL‐activated caspase, thus inhibiting DNA repair in OSCC cells. Therefore, ISL is a promising chemopreventive agent against oral cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E360–E371, 2016
Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1
Authors: Losón Oliver C. , Meng Shuxia , Ngo Huu , Liu Raymond , Kaiser Jens T. , Chan David C. 
Published: January 2015

AbstractMitochondrial fission requires recruitment of dynamin‐related protein 1 (Drp1) to the mitochondrial surface, where assembly leads to activation of its GTP‐dependent scission function. MiD49 and MiD51 are two receptors on the mitochondrial outer membrane that can recruit Drp1 to facilitate mitochondrial fission. Structural studies indicated that MiD51 has a variant nucleotidyl transferase fold that binds an ADP co‐factor essential for activation of Drp1 function. MiD49 shares sequence homology with MiD51 and regulates Drp1 function. However, it is unknown if MiD49 binds an analogous co‐factor. Because MiD49 does not readily crystallize, we used structural predictions and biochemical screening to identify a surface entropy reduction mutant that facilitated crystallization. Using molecular replacement, we determined the atomic structure of MiD49 to 2.4 Å. Like MiD51, MiD49 contains a nucleotidyl transferase domain; however, the electron density provides no evidence for a small‐molecule ligand. Structural changes in the putative nucleotide‐binding pocket make MiD49 incompatible with an extended ligand like ADP, and critical nucleotide‐binding residues found in MiD51 are not conserved. MiD49 contains a surface loop that physically interacts with Drp1 and is necessary for Drp1 recruitment to the mitochondrial surface. Our results suggest a structural basis for the differential regulation of MiD51‐ versus MiD49‐mediated fission.
Aligning Policy to Promote Cascade Genetic Screening for Prevention and Early Diagnosis of Heritable Diseases
Authors: George Rani , Kovak Karen , Cox Summer L. 
Published: January 2015

AbstractCascade genetic screening is a methodology for identifying and testing close blood relatives of individuals at increased risk for heritable conditions and follows a sequential process, minimizing testing costs and the number of family members who need to be tested. It offers considerable potential for cost savings and increased awareness of heritable conditions within families. CDC‐classified Tier 1 genomic applications for hereditary breast and ovarian cancer syndrome (HBOC), Lynch Syndrome (LS), and familial hypercholesterolemia (FH) are recommended for clinical use and support the use of cascade genetic screening. Most individuals are unaware of their increased risk for heritable conditions such as HBOC, LS, and FH. Consistent implementation of cascade genetic screening could significantly increase awareness and prevention of heritable conditions. Limitations to effective implementation of cascade genetic screening include: insufficient genetic risk assessment and knowledge by a majority of healthcare providers without genetics credentials; a shortage of genetic specialists, especially in rural areas; a low rate of reimbursement for comprehensive genetic counseling services; and an individual focus on prevention by clinical guidelines and insurance coverage. The family‐centric approach of cascade genetic screening improves prevention and early diagnosis of heritable diseases on a population health level. Cascade genetic screening could be better supported and augmented through changes in health policy.
Hegemann's disease and fishtail deformity: Aetiopathogenesis, radiographic appearance and clinical outcome
Authors: Claessen Femke M. A. P. , Louwerens Jan K. G. , Doornberg Job N. , van Dijk C. Niek , van den Bekerom Michel P. J. , Eygendaal Denise 
Published: January 2015

Purpose A systematic review regarding clinical studies on Hegemann's disease and fishtail deformity was performed with the aims to: (1) formulate the most up-to-date theory on aetiology in order to better define these conditions, (2) summarise the most frequent radiographic descriptions on radiographs and (3) give an overview of different treatment options. Methods A systematic review of studies to date on Hegemann's disease and fishtail deformity was performed. Studies were eligible if: (1) the article provides a description of Hegemann's disease or fishtail deformity, (2) original data of at least one patient was available, (3) the article was written in English, German or Dutch and (4) a full manuscript was available. Animal studies, reviews and expert opinions were not included. Results We included a total of 22 articles: seven regarding Hegemann's disease including eight patients and 15 regarding fishtail deformity including 58 patients. Conclusions Fishtail deformity and Hegemann's disease seem to be a spectrum of vascular disorders of the distal humerus, varying from a benign mild vascular disorder to a complete avascular necrosis after fractures. Additional imaging is advised to confirm the presence of a fishtail deformity, intra-articular loose bodies and signs of osteoarthritis to decide if, and what, operative treatment is needed. As long as no clear aetiology for both diseases exist and the clinical symptoms and radiographic appearance are difficult to distinguish, both entities should preferably be named as ‘vascular disturbance of the trochlear growth plate’ to overcome confusing definitions and discussions.
Intense Sweeteners, Appetite for the Sweet Taste, and Relationship to Weight Management
Authors: Bellisle France 
Published: January 2015

Abstract
High intensity, low-energy sweeteners (LES) are used by many consumers in order to limit energy intake and possibly facilitate body weight control. These beneficial effects are often questioned in the scientific and lay media. LES are frequently accused of stimulating and/or maintaining a liking for sweetness which in turn would be deleterious for adequate body weight control. Evidence for the specific effects of LES use on appetite for sweet products will be extracted from observational studies, experimental laboratory studies, randomized controlled trials, and finally brain imaging studies. While many of the existing studies cannot identify any causal links between use of LES and appetite for sweetness, randomized trials in children and adults suggest that use of LES tends to reduce rather than increase the intake of sugar-containing foods and to facilitate, rather than impair, weight loss.
A Comparative Study of four Oral Contrast Agents for Small Bowel Distension with Computed Tomography Enterography
Authors: Leduc Francois , De Anirban , Rebello Ryan , Muhn Narry , Ioannidis George 
Published: January 2015

Purpose To assess the efficacy of a variety of oral contrast agents in obtaining small bowel distention for computed tomography (CT) enterography examinations. Methods A retrospective study was developed to quantitatively assess small bowel luminal distension during CT enterography by using 4 contrast agents, which included water, Metamucil, polyethylene glycol, and lactulose. A total of 256 patients were enrolled in the study and included 64 individuals for each oral regimen. The widest loop of small bowel in each of 4 quadrants on representative coronal images was separately measured for luminal distension. Overall distension and the greatest number of “useful” quadrants were evaluated. Overall distension was calculated by summing the 4 quadrant values into an overall luminal diameter distention score (cm). A “useful” quadrant was defined as having a measurement of ≥2 cm. Each “useful” quadrant was assigned a score of 1, with values that ranged from 0-4. Results For overall distension, multivariable liner regression analysis showed that the lactulose group had a significantly higher overall distension value than Metamucil, polyethylene glycol, and water by 0.88, 0.92, and 1.63 cm, respectively, with 95% confidence interval. The categorical multivariable logistic regression analysis showed that the lactulose group had greater odds of having more “useful” quadrants than the Metamucil, polyethylene glycol, and water groups, with odds ratios of 3.51, 2.68, and 9.19, respectively. Conclusion Lactulose achieves better small bowel distension for CT enterography studies than the other 3 agents and, therefore, is the preferred oral regimen at our institution.
Effects of Celiprolol and Bisoprolol on Blood Pressure, Vascular Stiffness, and Baroreflex Sensitivity
Authors: Eguchi Kazuo , Hoshide Satoshi , Kario Kazuomi 
Published: January 2015

BACKGROUND
We tested the hypothesis that celiprolol and bisoprolol have differential effects on blood pressure (BP), flow-mediated dilation (FMD), and vascular stiffness.

METHODS
We analyzed 102 hypertensives (mean age: 59±14 years) who were being treated other than beta-blockers. They were randomized to receive add-on treatment with either celiprolol 100–200mg (C group) or bisoprolol 2.5–5mg (B group), and followed up for 3 months. In addition to clinic, home, and ambulatory BP monitoring, the FMD, radial augmentation index (AI), brachial–ankle pulse wave velocity (baPWV), urine albumin-to-creatinine ratio, and baroreflex sensitivity (BRS) were measured at baseline and at the end of the study.

RESULTS
Compared to the baseline values, home and 24-hour BP were significantly lowered in the third month in both groups (all Ps &lt; 0.05). Pulse rate (PR) and baPWV were reduced (P &lt; 0.001), and BRS was increased significantly only in the B group (P = 0.02). Radial AI was unchanged in the C group but was significantly increased in the B group (P &lt; 0.001). Central BP was significantly reduced in the C group (P = 0.003) but was unchanged in the B group. FMD was significantly increased in both groups (both P &lt; 0.01).

CONCLUSION
Bisoprolol achieved the greater reduction of PR and improved BRS and vascular stiffness, whereas, celiprolol reduced the central BP level. In treated hypertensive patients, add-on use of celiprolol may be favorable in uncomplicated stage of hypertension. On the other hand, bisoprolol may be useful in hypertensives with cardiac or vascular diseases who have advanced atherosclerotic changes and sympathetic nervous system activation.