bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Extension Sample Classification‐Based Extreme Learning Machine Ensemble Method for Process Fault Diagnosis
Authors: Xu Yuan , Chen Yan Jing , Zhu Qun Xiong 
Published: May 2014

AbstractIn order to achieve higher accuracy and faster response in complex process fault diagnosis, an extension sample classification‐based extreme learning machine ensemble (ESC‐ELME) method is proposed. In the realization process, the extension sample classification is used to divide the fault types. For each fault type, a specific extreme learning machine (ELM) is established and trained independently. Then, all specific ELMs are integrated to determine which fault is happened by the majority voting method. The proposed ESC‐ELME method is compared with the traditional ELM and a duty‐oriented hierarchical artificial neural network in fault diagnosis of the Tennessee Eastman process. The results demonstrate that the proposed method provides higher diagnosis accuracy and faster response.
A Photoresponsive Wettability Switch Based on a Dimethylamino Calix[4]arene
Authors: Zhang Xiaoyan , Zhao Haiyang , Tian Demei , Deng Hongtao , Li Haibing 
Published: May 2014

AbstractA photoreversible switch based on a photoresponsive host–guest system consisting of dimethylamino calix[4]arene L and 4‐(phenylazo)benzoic acid (O) is reported. The host L exhibited selective binding and release of O on UV and visible irradiation at 450 and 365 nm, respectively. Moreover, the photoresponsive host–guest complex was applied as a photocontrolled wettability switch on a functional micro/nanostructured silicon surface, and is thus promising for applications in sensors and microfluidic devices.
Problems in Processing of Metalliferous Composites from Lithium‐Containing Electrical Devices and Batteries
Authors: Jäckel H.‐Georg , Wuschke Lutz , Peuker Urs A. 
Published: May 2014

AbstractDie Verknappung metallischer Ressourcen führt zu Bemühungen, auch komplizierte Werkstoffmischungen einer wirtschaftlichen Aufbereitung zuzuführen. Auftretende Probleme erfordern eine Erweiterung des Recyclingbegriffs analog zur Primärrohstoffaufbereitung. Ausgehend von einer allgemeinen Klassifizierung der Werkstoffverbunde werden anhand lithiumhhaltiger Gerätebatterien die Aufkommenssituation, Probleme der Erfassung und Charakterisierung, verschiedene Aufbereitungsszenarien sowie eigene Ergebnisse vorgestellt. Anhand der Werthaltigkeit wird versucht, die Grenzen einer wirtschaftlichen Aufbereitung aufzuzeigen.
Minimum profile Hellinger distance estimation for a semiparametric mixture model
Authors: Xiang Sijia , Yao Weixin , Wu Jingjing 
Published: May 2014

AbstractIn this paper, we propose a new effective estimator for a class of semiparametric mixture models where one component has known distribution with possibly unknown parameters while the other component density and the mixing proportion are unknown. Such semiparametric mixture models have been often used in multiple hypothesis testing and the sequential clustering algorithm. The proposed estimator is based on the minimum profile Hellinger distance (MPHD), and its theoretical properties are investigated. In addition, we use simulation studies to illustrate the finite sample performance of the MPHD estimator and compare it with some other existing approaches. The empirical studies demonstrate that the new method outperforms existing estimators when data are generated under contamination and works comparably to existing estimators when data are not contaminated. Applications to two real data sets are also provided to illustrate the effectiveness of the new methodology.The Canadian Journal of Statistics42: 246–267; 2014 © 2014 Statistical Society of Canada
Graphical lassos for meta‐elliptical distributions
Authors: Bilodeau Martin 
Published: May 2014

AbstractGaussian graphical lasso is a tool for estimating sparse graphs using a Gaussian log‐likelihood with anpenalty on the inverse covariance matrix. This paper proposes a generalization to meta‐elliptical distributions. Conditional uncorrelatedness is characterized in meta‐elliptical families. The proposed meta‐elliptical and re‐weighted Kendall graphical lassos are computed from pseudo‐observations which are functions of ranks of observations. They are invariant to strictly increasing transformations of the variables and do not assume the existence of moments. Simulations of receiver operating characteristic curves show noticeable improvements (in comparison with graphical lassos designed for meta‐Gaussian distributions) for distributions which are not meta‐Gaussian. These improvements are realized without ill effects when the distribution is meta‐Gaussian. Deterministic and random contaminations of data are used to verify the robustness of the re‐weighted Kendall graphical lasso.The Canadian Journal of Statistics42: 185–203; 2014 © 2014 Statistical Society of Canada
3‐(2‐Oxoethylidene)indolin‐2‐one Derivatives Activate Nrf2 and Inhibit NF‐κB: Potential Candidates for Chemoprevention
Authors: Nagle Amrita A. , Reddy Shridhivya A. , Bertrand Helene , Tajima Hisashi , Dang Truong‐Minh , Wong Siew‐Cheng , Hayes John D. , Wells Geoffrey , Chew Eng‐Hui 
Published: May 2014

AbstractInduction of cytoprotective phase 2 enzymes through inhibition of Keap1, a repressor of transcription factor Nrf2, is a cancer‐prevention strategy. Compounds that elicit antiinflammatory and cytoprotective effects are promising candidates for chemoprevention. Novel analogues of 1‐methyl‐3‐(2‐oxopropylidene)indolin‐2‐one (‘supercinnamaldehyde’; SCA) were synthesized, and their abilities to induce cytoprotective responses through Nrf2 induction and to suppress inflammatory responses were examined. 1‐Methyl‐3‐(2‐oxo‐2‐phenylethylidene)indolin‐2‐one (6) was identified as the lead compound. The compounds showed induction of Nrf2‐dependent phase 2 enzymes in Keap1+/+ mouse embryonic fibroblasts (MEFs), which was abrogated in Keap1−/− MEFs. The compounds also displayed a suppressive effect on NF‐κB signaling that was at least partly responsible for inhibition of lipopolysaccharideinduced inflammatory responses. These SCA analogues exhibited cytoprotective and anti‐inflammatory activities and may be developed further as chemopreventive agents.
Elastic–viscoplastic modeling of soft biological tissues using a mixed finite element formulation based on the relative deformation gradient
Authors: Weickenmeier J. , Jabareen M. 
Published: May 2014

SUMMARYThe characteristic highly nonlinear, time‐dependent, and often inelastic material response of soft biological tissues can be expressed in a set of elastic–viscoplastic constitutive equations. The specific elastic–viscoplastic model for soft tissues proposed by Rubin and Bodner (2002) is generalized with respect to the constitutive equations for the scalar quantity of the rate of inelasticity and the hardening parameter in order to represent a general framework for elastic–viscoplastic models. A strongly objective integration scheme and a new mixed finite element formulation were developed based on the introduction of the relative deformation gradient—the deformation mapping between the last converged and current configurations. The numerical implementation of both the generalized framework and the specific Rubin and Bodner model is presented. As an example of a challenging application of the new model equations, the mechanical response of facial skin tissue is characterized through an experimental campaign based on the suction method. The measurement data are used for the identification of a suitable set of model parameters that well represents the experimentally observed tissue behavior. Two different measurement protocols were defined to address specific tissue properties with respect to the instantaneous tissue response, inelasticity, and tissue recovery. Copyright © 2014 John Wiley & Sons, Ltd.
Photoelectrochemical Water Splitting at Semiconductor Electrodes: Fundamental Problems and New Perspectives
Authors: Peter Laurence M. , Upul Wijayantha K. G. 
Published: May 2014

AbstractSome fundamental aspects of light‐driven water splitting at semiconductor electrodes are reviewed along with recent experimental and theoretical progress. The roles of thermodynamics and kinetics in defining criteria for successful water‐splitting systems are examined. An overview of recent research is given that places emphasis on new electrode materials, theoretical advances and the development of semi‐quantitative experimental methods to study the dynamics of light‐driven water‐splitting reactions. Key areas are identified that will need particular attention as the search continues for stable, efficient and cost‐effective light‐driven photoelectrolysis systems that exploit electron/hole separation in semiconductor/electrolyte junctions.
Novel Nanoscroll Structures from Carbon Nitride Layers
Authors: Perim Eric , Galvao Douglas S. 
Published: May 2014

AbstractNanoscrolls (papyrus‐like nanostructures) are very attractive structures for a variety of applications, owing to their tunable diameter and large accessible surface area. They have been successfully synthesized from different materials. In this work, we investigate, through fully atomistic molecular dynamics simulations, the dynamics of scroll formation for a series of graphene‐like carbon nitride (CN) two‐dimensional systems: g‐CN, triazine‐based g‐C3N4, and heptazine‐based g‐C3N4. Our results show that stable nanoscrolls can be formed for each of these structures. Possible synthetic routes to produce these nanostructures are also addressed.
Delay constraint multipath routing for wireless multimedia ad hoc networks
Authors: Sun Yanjing , Sun Jianguang , Zhao Fangfang , Hu Zhuoxian 
Published: May 2014

SummaryAccording to the disadvantages of real time and continuity for multimedia services in ad hoc networks, a delay constraint multipath routing protocol for wireless multimedia ad hoc networks, which can satisfy quality of service (QoS) requirement (QoS multipath optimized link state routing [MOLSR]), is proposed. The protocol firstly detects and analyzes the link delay among the nodes and collects the delay information as the routing metric by HELLO message and topology control message. Then, through using the improved multipath Dijkstra algorithm for path selection, the protocol can gain the minimum delay path from the source node to the other nodes. Finally, when the route is launched, several node‐disjoint or link‐disjoint multipaths will be built through the route computation. The simulation and test results show that QoS‐MOLSR is suitable for large and dense networks with heavy traffic. It can improve the real time and reliability for multimedia transmission in wireless multimedia ad hoc networks. The average end‐to‐end delay of QoS‐MOLSR is four times less than the optimized link state routing. Copyright © 2014 John Wiley & Sons, Ltd.
Profound defects in β‐cell function in screen‐detected type 2 diabetes are not improved with glucose‐lowering treatment in the Early Diabetes Intervention Program (EDIP)
Authors: Hannon Tamara S. , Kirkman M. S. , Patel Yash R. , Considine Robert V. , Mather Kieren J. 
Published: May 2014

AbstractBackgroundFew studies have measured the ability of interventions to affect declining β‐cell function in screen‐detected type 2 diabetes. The Early Diabetes Intervention Programme (ClinicalTrials.gov NCT01470937) was a randomized study based on the hypothesis that improving postprandial glucose excursions with acarbose would slow the progression of fasting hyperglycaemia in screen‐detected type 2 diabetes. In the Early Diabetes Intervention Programme, the effect of acarbose plus lifestyle advice on progression of fasting hyperglycaemia over a 5‐year period was not greater than that of placebo. However, there was an early glucose‐lowering effect of the trial. The objective of the current secondary analysis was to describe β‐cell function changes in response to glucose lowering.MethodsParticipants were overweight adult subjects with screen‐detected type 2 diabetes. β‐cell function was measured using hyperglycaemic clamps and oral glucose tolerance testing. The primary outcome was the change in β‐cell function from baseline to year 1, the time point where the maximal glucose‐lowering effect was seen.ResultsAt baseline, participants exhibited markedly impaired first‐phase insulin response. Despite significant reductions in weight, fasting plasma glucose (PG) and 2‐h PG, there was no clinically significant improvement in the first‐phase insulin response. Late‐phase insulin responses declined despite beneficial glycaemic effects of interventions.ConclusionsInsulin secretion is already severely impaired in early, screen‐detected type 2 diabetes. Effective glucose‐lowering intervention with acarbose was not sufficient to improve insulin secretion or halt the decline of β‐cell function. Copyright © 2014 John Wiley & Sons, Ltd.
Nerve Agent Degradation with Polyoxoniobates
Authors: Kinnan Mark K. , Creasy William R. , Fullmer Lauren B. , Schreuder‐Gibson Heidi L. , Nyman May 
Published: May 2014

AbstractInvited for the cover of this issue is the group of May Nyman in the Department of Chemistry at Oregon State University, along with Mark Kinnan (Sandia National Laboratories), Heidi Schreuder‐Gibson (U.S. Army Natick), and Bill Creasy (Edgewood Chemical Biological Center). The cover image shows the degradation of nerve gas upon encountering a net of polyoxoniobate Lindqvist ions.
Stereoselective Synthesis of β‐Sulfinylamino Isocyanides and 2‐Imidazolines
Authors: Janssen Guido V. , Vicente‐García Esther , Vogel Wouter , Slootweg J. Chris , Ruijter Eelco , Lammertsma Koop , Orru Romano V. A. 
Published: May 2014

AbstractAn efficient asymmetric synthesis of β‐sulfinylamino isocyanides is reported on the basis of the highly diastereoselective addition of 9‐isocyanofluorene to optically pure N‐tert‐butanesulfinimines. The resulting optically pure isocyanides readily cyclized to give optically pure 2‐imidazolines upon removal of the sulfinyl group. Furthermore, the β‐sulfinylamino isocyanides were used as chiral inputs in Ugi and Passerini multicomponent reactions to generate new types of (pseudo)peptide scaffolds.
The Fuel of Intimacy
Authors: Unterstell Rembert 
Published: May 2014

AbstractIn the media, it's often described as the “cuddle hormone” or the “orgasm hormone”. But oxytocin is also attracting a lot of attention among scientists. Biopsychologist Markus Heinrichs talks about the unique qualities and secrets of this hormone — and its possible use in psychotherapy for people with severe social disorders.
Transoral robotic excision of ectopic lingual thyroid: Case series and literature review
Authors: Prisman Eitan , Patsias Alexis , Genden Eric M. 
Published: May 2014

AbstractBackgroundSurgical excision of an ectopic lingual thyroid has traditionally been associated with significant morbidity and has therefore been reserved for patients with severe obstructive symptoms or suspected malignancy. Transoral robotic surgery (TORS) has provided a minimally invasive approach to completely and safely excise ectopic lingual thyroid.MethodsThree index cases were identified from the detailed clinical database of TORS patients. A systematic review of the management of ectopic lingual thyroid in the English literature was performed.ResultsTORS‐assisted excision of a lingual thyroid gland was successfully performed in 3 patients with excellent functional outcomesConclusionTORS‐assisted excision of an ectopic lingual thyroid is a safe and feasible treatment modality with minimal morbidity, and, in experienced hands, should be offered as a valid treatment for this pathology. © 2015 Wiley Periodicals, Inc. Head Neck 37: E88–E91, 2015
Structural Characterization of the Drug Translocation Path of MRP1/ABCC1
Authors: Amram Shay , Ganoth Assaf , Tichon Or , Peer Dan , Nachliel Esther , Gutman Menachem , Tsfadia Yossi 
Published: May 2014

AbstractThe rapid clearance of drugs from human cells is carried out by MRP1 and other proteins of the ABC transporter superfamily. Selective mutations carried out by DeGorter indicated that replacement of Y324 by phenylalanine (but not by tryptophan or alanine) enhances the capacity of the protein to extrude various drugs. In this study we investigate the effect of mutation on the structure of the isolated transmembrane domain of MRP1 through molecular dynamics simulations of the protein embedded in a POPC membrane. The simulations reveal a persistent tendency of the translocation path to experience a partial constriction, losing ∼50 % of the water inside the conducting path. While the Wt, Y324W and Y324A transporters all experienced the same constriction, the Y324F transporter, the one having a higher clearance rate than the Wt, retains a fully open configuration. The structure of the Y324F mutant reveals an alternate set of stabilizing interactions that force a kink in transmembrane helix 6, which keeps the protein in a fully open outward‐facing configuration thus providing a molecular‐level account for the higher activity of the mutant. The ability of the simulations to corroborate the experimental observations implies that the homology model of MRP1 is a proper representation of the internal interactions between the residues in the protein, and can be used as a reliable model for studying the human multidrug resistance function of the MRP1 protein.
From Catalytic Mechanism to Rational Design of Reversible Covalent Inhibitors of Serine and Cysteine Hydrolases
Authors: Shokhen Michael , Hirsch Michal , Khazanov Netaly , Ozeri Rachel , Perlman Nurit , Traube Tamar , Vijayakumar Subramaniam , Albeck Amnon 
Published: May 2014

AbstractMechanistic studies of catalysis and the inhibition of serine and cysteine proteases afford new and sometimes surprising insights, challenging conventional dogmas in enzymology. The intrinsic source of the difference in the catalytic mechanisms of serine and cysteine hydrolases, the origin of the stability of the enzymeinhibitor complex in serine proteases, and the structures and mechanisms of catalysis and inhibition in cysteine proteases are not just intellectually interesting; our findings provide a mechanistic basis to understand the trend in the binding affinity of “warheads” of reversible covalent (reaction coordinate analogue, RCA) inhibitors. The theoretically derived covalent descriptors W1 and W2 differentiate serine and cysteine hydrolases and account for the energetic contribution of the new covalent bond in the enzymeinhibitor complex. The W1 and W2 descriptors are at the heart of our enzyme mechanism based method (EMBM); a new computer‐assisted drug design tool for the filtration of inhibitor warheads by activity. EMBM is unique because it accounts for both covalent and noncovalent interactions of RCA inhibitors with their target enzymes.
The Molecular Controlled Semiconductor Resistor: A Universal Sensory Technology
Authors: Capua Eyal , Kumar Tatikonda Anand , Tkachev Maria , Naaman Ron 
Published: May 2014

AbstractWe review some of the sensors based on the molecular control semiconductor resistor (MOCSER) technology. The technology can be applied for developing highly sensitive and selective molecular sensors that operate both in gas and in liquid environments. Specifically, we describe here a set of GaAs gas‐phase sensors based on an array constructed from several elements, each coated with a different sensing molecule. Coating the same semiconductor device with an ultrathin polymer layer also allows the use of the device in a harsh liquid environment and in performing measurements in physiological liquids. Hence, the MOCSER‐based platform opens the way for producing inexpensive, easy to use, and robust sensors for a wide variety of applications.
Progenitor Cells in Proximal Airway Epithelial Development and Regeneration
Authors: Lynch Thomas J. , Engelhardt John F. 
Published: May 2014

ABSTRACTMultiple distinct epithelial domains are found throughout the airway that are distinguishable by location, structure, function, and cell‐type composition. Several progenitor cell populations in the proximal airway have been identified to reside in confined microenvironmental niches including the submucosal glands (SMGs), which are embedded in the tracheal connective tissue between the surface epithelium and cartilage, and basal cells that reside within the surface airway epithelium (SAE). Current research suggests that regulatory pathways that coordinate development of the proximal airway and establishment of progenitor cell niches may overlap with pathways that control progenitor cell responses during airway regeneration following injury. SMGs have been shown to harbor epithelial progenitor cells, and this niche is dysregulated in diseases such as cystic fibrosis. However, mechanisms that regulate progenitor cell proliferation and maintenance within this glandular niche are not completely understood. Here we discuss glandular progenitor cells during development and regeneration of the proximal airway and compare properties of glandular progenitors to those of basal cell progenitors in the SAE. Further investigation into glandular progenitor cell control will provide a direction for interrogating therapeutic interventions to correct aberrant conditions affecting the SMGs in diseases such as cystic fibrosis, chronic bronchitis, and asthma. J. Cell. Biochem. 115: 1637–1645, 2014. © 2014 Wiley Periodicals, Inc.
CD49f‐Positive Testicular Cells in Saanen Dairy Goat Were Identified as Spermatogonia‐Like Cells by miRNA Profiling Analysis
Authors: Wu Jiang , Liao Mingzhi , Zhu Haijing , Kang Kai , Mu Hailong , Song Wencong , Niu Zhiwei , He Xin , Bai Chunling , Li Guangpeng , Li Xinping , Hua Jinlian 
Published: May 2014

ABSTRACTmiRNAs, a type of small RNA, play critical roles in mammalian spermatogenesis. Spermatogonia are the foundation of spermatogenesis and are valuable for the study of spermatogenesis. However, the expression profiling of the miRNAs in spermatogonia of dairy goats remains unclear. CD49f has been one of the surface markers used for spermatogonia enrichment by magnetic activated cell sorting (MACS). Therefore, we used a CD49f microbead antibody to purify CD49f‐positive and ‐negative cells of dairy goat testicular cells by MACS and then analysed the miRNA expression in these cells in depth using Illumina sequencing technology. The results of miRNA expression profiling in purified CD49f‐positive and ‐negative testicular cells showed that 933 miRNAs were upregulated in CD49f‐positive cells and 916 miRNAs were upregulated in CD49f‐negative cells with a twofold increase, respectively; several miRNAs and marker genes specific for spermatogonial stem cells (SSCs) in testis had a higher expression level in CD49f‐positive testicular cells, including miR‐221, miR‐23a, miR‐29b, miR‐24, miR‐29a, miR‐199b, miR‐199a, miR‐27a, and miR‐21 and CD90, Gfra1, and Plzf. The bioinformatics analysis of differently expressed miRNAs indicated that the target genes of these miRNAs in CD49f‐positive cells were involved in cell‐cycle biological processes and the cell‐cycle KEGG pathway. In conclusion, our comparative miRNAome data provide useful miRNA profiling data of dairy goat spermatogonia cells and suggest that CD49f could be used to enrich dairy goat spermatogonia‐like cells, including SSCs. J. Cell. Biochem. 115: 1712–1723, 2014. © 2014 Wiley Periodicals, Inc.