bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in self-reported disruptions in mental health treatment during COVID-19 in a national household sample: impact of severity of functional impairment
Authors: Wang Margaret , Graupensperger Scott , olfson mark , Bareis Natalie , edlund mark , Monroe-DeVita Maria , Kessler Ronald , Tennison Mackenzie , Winans Katherine , Chwastiak Lydia 
Published: July 2024

Abstract

Objective: This report uses data from Mental Disorders Prevalence Study (MDPS), a large epidemiologic study that provided national prevalence estimates of seven mental disorders based on the Structured Clinical Interview for DSM-5 (SCID), to assess the odds of treatment disruption during COVID for SMI and non-SMI groups.
Methods: This cross-sectional study conducted from 2020 to 2022 included 2,810 household participants with any lifetime mental health treatment. Weighted logistic regressions estimated the odds of reporting disruptions in access to mental health care or psychotropic prescriptions due to COVID. SMI was broadly defined as having an MDP diagnosis and serious functional impairment (GAF ≤50, a validated and widely used cutoff). Non-SMI groups were a mental diagnosis without serious impairment (MDPS diagnosis, GAF >50) and any lifetime treatment and no serious impairment (no MDPS diagnosis, GAF >50).
Results:The SMI and mental disorder without serious impairment groups had approximately 6.4- and 2.4- greater odds, respectively, of reporting inability to access mental health care and 4- and 3- greater odds, respectively, of having prescriptions delayed, relative to the group with any lifetime treatment. Among those with serious mental illness, having Medicare insurance increased the odds of reporting inability to access mental health care.
Conclusions: Individuals with SMI were much more likely to experience treatment disruptions throughout the pandemic than non-SMI groups.
Predicting Hypertension in Rangpur Region: A Machine Learning Approach
Authors: Islam Dina , Akter Taiaba , Tasnim Mst.Nazifa , Ria Most.Sadia Islam , Badhan Iffat Ara , Haque A K M Mahmudul 
Published: July 2024

Abstract

This study presents a machine learning approach to forecast hypertension within urban inhabitants, focusing on the Rangpur district, Bangladesh for data col- lection and model training. Ten machine learning algorithms, such as Logistic Regression, Gaussian Naive Bayes (GNB), Support Vector Machine (SVM), K- Nearest Neighbor (K-NN), Decision Tree (DT), Random Forest (RF), Bagging, AdaBoost, Gradient Boosting (GB), and Extra Tree (ET) are utilized to enhance the accuracy of predicting hypertension risk in this specific region. Data gath- ered from 611 patients across different healthcare facilities, containing details like blood pressure measurements, medical records, and hypertension diagno- sis, form the dataset for analysis. The aim of this research is to enhance early detection techniques and customize public health interventions in Rangpur City. Examination of the primary data establishes a substantial association between hypertension and blood pressure parameters (0.79 for Sys BP, 0.78 for Dia BP) in comparison to other variables. Evaluation of model performance is based on metrics like accuracy, precision, recall, and F1-score. Findings demonstrate that the AdaBoost model exhibits superior performance indicators, achieving 98.37% accuracy, 100% precision, 96.87% recall, and an F1-score of 98.39% when trained on 70% of the dataset and evaluated on 30%, with a focus on blood pressure. Even excluding this attribute, the AdaBoost model surpasses others with 78.86% accu- racy, 77.14% precision, 84.38% recall, and an F1-score of 78.79% when trained on 80% of the dataset and tested on 20%. By prioritizing early detection and pre- ventive healthcare, Bangladesh’s healthcare system can diminish expenses linked to costly therapies and hospital stays.
Comparative real-world retention rate and safety of Biosimilar IBI303 versus Humira in Ankylosing Spondylitis
Authors: Cheng Xiaogui , Fu Zhongchao , Liu Jiang , Cheng Beibei , Shi Rangeng , Xu Xiayan , Zhang Peng , Cao Weiling , Cao Yaohua 
Published: July 2024

Abstract

OBJECTIVE
Biosimilars play an important role in reducing the economic burden on patients, but the effectiveness of biosimilars in real-world is also being challenged, Therefore, we evaluated Humira and IBI303 for ankylosing spondylitis by retention rate and safety through real-world data.
METHODS
We extracted patient information from the hospital information system of Shenzhen Luohu People’s Hospital, the time range is from May 1, 2020, to December 31, 2023, and conducted a retrospective study. The primary study outcome was the adalimumab retention rate at week 52 and it was estimated through survival analysis.
RESULTS
The data of 106 patients with ankylosing spondylitis were analyzed. The retention rates of 38 patients using Humira at 12 week and 52 week were 0.87 (95% CI: 0.81to 0.92) and 0.44 (95% CI: 0.34, 0.52), in IBI303 group were 0.90 (95% CI: 0.68 to 0.93),0.63 (95% CI: 0.57 to 0.69), respectively. Drug exposure every 4 weeks of first 52 weeks were 55.0 (44.2–66.7) and 55.6 (43.3–69.6) in Humira and IBI303 group, respectively. The incidence of adverse reactions was no statistically significant difference between the Humira and IBI303 groups (P > 0.05). However, The Humira group had significantly higher median costs in the first year than the IBI303 group (P = 0.004).
CONCLUSION
In Chinese ankylosing spondylitis patients, there is no difference in retention rate and safety between generic and brand-name adalimumab in real world use, but IBI303 is the more cost-effective choice.
Transformer-based classification of visceral pain-related local field potential patterns in the brain
Authors: Kayama Tasuku , Tamura Atsushi , Xiaoying Tuo , Tsutsui Ken-Ichiro , Kitajo Keiichi , Sasaki Takuya 
Published: July 2024

Abstract

Neuronal ensemble activity entrained by local field potential (LFP) patterns underlies a variety of brain functions, including emotion, cognition, and pain perception. Recent advances in machine learning approaches may enable more effective methods for analyzing LFP patterns across multiple brain areas than conventional time-frequency analysis. In this study, we tested the performance of two machine learning algorithms, AlexNet and the Transformer models, to classify LFP patterns in eight pain-related brain regions before and during acetic acid-induced visceral pain behaviors. Over short time windows lasting several seconds, applying AlexNet to LFP power datasets, but not to raw time-series LFP traces from multiple brain areas, successfully achieved superior classification performance compared with simple LFP power analysis. Furthermore, applying the Transformer directly to the raw LFP traces achieved significantly superior classification performance than AlexNet when using LFP power datasets. These results demonstrate the utility of the Transformer in the analysis of neurophysiological signals, and pave the way for its future applications in the decoding of more complex neuronal activity patterns.
Production and Biological Activities of Exopolysaccharides Synthesized by Thermophilic Bacilli Isolated from Hot Springs in Türkiye
Authors: Aytar Mehmet , Uygun Deniz Aktaş , Başbülbül Gamze 
Published: July 2024

Abstract

A total of one hundred seven thermophilic bacteria were screened for their ability to produce exopolysaccharides. Nine isolates belonging to Geobacillus, Parageobacillus, Aeribacillus and Anoxybacillus genera with highest EPS quantities were chosen and purified EPSs used for biological activity studies. EPS yields of selected thermophilic bacteria ranged between 117–419 mg/L. Among the tested EPSs, 61, 106 and 261 showed antibacterial effect against E. faecalis JH2-2 at a concentration of 15 mg/mL. EPS samples had significant antioxidant capacity, especially EPS 134, with highest DPPH radical scavenging activity of 100% at a concentration of 5 mg/mL and strongest reducing power. EPS 20, showed highest lipid peroxidation inhibition effect at a rate of 31%. EPSs displayed weak alpha amylase inhibition activity when compared with standart acarbose. The prebiotic indices of EPSs 20, 61, 76, 89, 134 and 261 were found to be higher than that of inulin, a representative prebiotic carbohydrate for all tested lactic acid bacteria in the study. All examined EPSs inhibited the biofilms formed by various bacteria depending on the test strain. Results indicated that thermophilic EPSs had remarkable antioxidant, prebiotic, and antibiofilm activities. Therefore, EPSs characterized in this study may have technological applications in health and food fields.
Genome-wide association studies revealed genetic loci and candidate genes for pod-related traits in peanut
Authors: Chen Wen , Yue Yunlai , Chen Chengmeng , Yang Junchen , Chen Yong , Zhang Hui 
Published: July 2024

Abstract

Peanut pod maturity and splitting are two important traits that can significantly affect yields and quality. However, the investigation of the natural variability and genetic underpinnings of these two characteristics in peanuts remains limited. In this research, a comprehensive genome-wide association studies (GWAS) was carried out to analyze peanut pod maturity and splitting percentage utilizing U.S. peanut mini core collection. A total of 19 distinct single nucleotide polymorphisms (SNPs) were detected from this study, with 6 and 13 SNPs being specifically linked to pod maturity and splitting traits, respectively. Based on these loci, a total of 95 genes were identified. Our study has important practical and theoretical significance for the molecular breeding of high-yielding peanuts and the development of superior high-yield peanut varieties.
Assessing hand motor function in chronic immune-mediated neuropathies - a proof-of-concept study using a data glove
Authors: Gilliam Elisa , Achenbach Pascal , Suemmermann Gernot J. , Wessely Manuel N. , Rossmanith Peter , Dohrn Maike F. , Schulz Jörg B. , Waschbisch Anne , Brunkhorst Robert 
Published: July 2024

Abstract

Background
Chronic immune-mediated neuropathies are clinically heterogeneous and require regular, objective, and multidimensional monitoring to individualize treatment. However, established outcome measures are insufficient regarding measurement quality criteria or functional relevance. Wearables such as data gloves might be helpful, allowing repeated quantification of complex everyday life-relevant motor function of the hand. This proof-of-concept study therefore aimed to evaluate validity and test-retest reliability of a data glove, as well as its ability to identify and monitor patients with hand motor impairment.
Methods
25 patients with chronic inflammatory demyelinating polyneuropathy or multifocal motor neuropathy were followed-up for at time points during maintenance therapy with intravenous immunoglobulin. 14 of them showed clinically relevant hand motor impairment. We examined the patients’ hand function using a data glove which quantifies the range of motion (ROM) of the hand based on three different movement patterns. In addition, clinical outcome parameters (grip strength measurement, MRC Sum Score, INCAT disability score), nerve conduction studies (NCS), and high-resolution ultrasound (HRUS) were performed, and patient-reported outcome measures (PROMs) like the R-ODS were assessed. We calculated correlation coefficients, performed Receiver operating characteristic-, as well as correlation analyses for the glove data and clinical outcome parameters. Longitudinal analyses were based on a Linear Mixed Model.
Results
We found good to excellent test-retest reliability for the ROM in all glove movement patterns (Intraclass correlation coefficients = 0.83–0.94), underlining the ability to capture clinical stability. Moreover, the glove revealed sufficient sensitivity and specificity in recognizing hand motor impairment (area under the curve (AUC): 0.714–0.780) and was superior to NCS and HRUS (AUC: 0.552/0.701). Additionally, the data glove proofed to be a valid tool, as we demonstrated moderate to strong, significant correlations between the glove and established clinical parameters (esp. Vigorimeter), as well as PROMs (esp. R-ODS).
Conclusions
This data glove allowed for a non-invasive assessment of the hand motor function and yielded investigator-independent results that reliably reflected individual functional deficits with relevance to everyday life. Further studies should examine the ability to predict clinically meaningful response to immunomodulatory treatment as well as to support and monitor rehabilitation progress, also including other neurological diseases.
Microbacterium rhizophilus sp. nov., an indole acetic acid-producing actinobacterium isolated from rhizosphere soil
Authors: Liu Haifei , Yang Quan , Li Jiawei , Yang Lifang , Zhao Aolin , Huang Ying , Liu Hongcun , Wu Shujing , Jiang Mingguo 
Published: July 2024

Abstract

A novel gram-positive, short rod, aerobic, non-motile and non-spore-forming actinobacterial strain, designated GXG1230T was isolated from the rhizosphere soil of a coastal mangrove forest in Beihai city, Guangxi Zhuang Autonomous Region, PR China. Phylogenetic analysis based on 16S rRNA sequences revealed that strain GXG1230T was affiliated with the genus Microbacterium. Additionally, it demonstrated a high degree of similarity to Microbacterium paludicola US15T (97.9%) and Microbacterium marinilacus YM11-607T (97.3%). Chemotaxonomic characteristics showed that the whole-cell sugars were glucose, xylose, rhamnose, galactose and malados. Menaquinones MK-11 and MK-12 were detected as respiratory quinones. Lysine was found in the peptidoglycan hydrolysate and the polar lipids were diphosphatidyl glycerol, phospholipids and unidentified glycolipid. The major fatty acids were iso-C14:0, iso-C16:0, anteiso-C15:0 and anteiso-C17:0. The strain GXG1230T exhibited a genomic DNA G + C content of 71.7%. Furthermore, the average nucleotide identity values of GXG1230T with the reference strain were 75.4% and 81.9%, respectively, while the digital DNA-DNA hybridization values were 20.1% and 25.0%. Based on physiological, chemotaxonomic and phylogenetic information, strain GXG1230T is considered to represent a novel species of the genus Microbacterium, for which the name Microbacterium rhizophilus sp.nov is proposed, with GXG1230T (= MCCC 1K09223T = KCTC 59252T) as the type strain.
Pancreatic Masses in Children: A Single-Center Experience Over Two Decades
Authors: McRae Joyce J. L. H. , Thobani Humza , Sacks Marla A. , Raymond Steven L. , Shah Adil , Radulescu Andrei , Khan Faraz A. 
Published: July 2024

Abstract

Purpose: Pancreatic masses are extremely rare in pediatric patients, with limited data available. This lack of data makes the diagnosis and management of these tumors in children extremely challenging. Therefore, we aimed to describe the presentations, clinical course, and outcomes of children with pancreatic tumors at our center.
Methods: A retrospective analysis was performed of all pediatric patients diagnosed with pancreatic masses between 2003 and 2022 in an academic freestanding children’s hospital. Data including demographics, clinical presentation, workup, management, and subsequent morbidity and mortality, were collected and aggregated. Furthermore, we reviewed cases of pancreatic tumor resections in the National Surgical Quality Improvement Program – Pediatric (NSQIP-P) database to identify common adverse outcomes and measures for quality improvement.
Results: In total, 17 patients were identified at our institution. Diagnoses included Solid Pseudopapillary (n=9), Gastrinoma (n=1), Rhabdomyosarcoma (n=2), Pancreatoblastoma (n=2), Insulinoma (n=1). Two patients did not have a histopathologic diagnosis and were excluded from subsequent analysis. Overall, 12 patients underwent surgical intervention, with the most common procedures being pancreaticoduodenectomy and distal pancreatectomy, and all 12 were known to be alive at last contact. There were 3 deaths, all due to complications related to metastatic disease. Furthermore, 30-day postoperative outcomes in the NSQIP-P dataset are excellent, with negligible morbidity and no mortalities after the index surgery.
Conclusions: Children with pancreatic tumors amenable to surgical resection appear to have adequate long-term survival. Short-term outcomes at diagnosis are excellent and mainly appear to be influenced by the presence of metastatic disease at initial presentation.
Evidence based practices in music therapy education: An international survey
Authors: Short Alison , Heiderscheit Annie 
Published: July 2024

Abstract

Despite considerable improvements in the clinical practice evidence base, scant evidence exists about music therapy teaching practices either locally or worldwide and how to best convey music therapy knowledge and skills via the learning and teaching process. Our broad study explores educational practices of music therapy educators around the world via a custom designed and internationally disseminated survey tool. The current paper focuses particularly on the seven research-based principles which support excellence in teaching and learning (Ambrose et al., 2010) and how these are applied within the international music therapy education community. Sixty-one experienced music therapy educators from 19 countries completed the mixed method online survey, with data analysed statistically and thematically. Results suggest that music therapy educators currently reflect on their teaching practices but need further information about educational research to support their training needs. Findings further suggest that additional evidence-based teaching materials need to be developed, provided, and accessed to support music therapy educators around the world.
Feasibility and Safety of Robotic Assisted Surgical Approach in Median Arcuate Ligament Syndrome – A Systematic Review
Authors: Gunjiganvi Mallikarjun , Marthandam Sri Kanth , Murugesan Rajeswari , Palaniappan Raj 
Published: July 2024

Abstract

Median arcuate ligament syndrome (MALS) is rare syndrome and is diagnosis of exclusion. Though first robotic median arcuate ligament release (MALR) was described in 2007, there are only a few case reports (CR), case series (CS) and retrospective cohort studies (RCS) published in literature. The purpose of this study was to assess the feasibility and safety of robotic assisted MALR (r-MALR). PubMed, Embase and Cochrane databases were searched (last search December 2023) for articles reporting R-MALR. All studies including CR, CS, RCS reporting technical feasibility (operating time and rate of conversions; safety (intraoperative complications, blood loss, post-operative complications), and outcome (length of stay [LoS]) were included (PROSPERO: CRD42024502792). A total of 23 studies (8-CR, 5-CS, 10-RCS) with total 290 patients were available in literature. Except 1-RCS, all studies reported age and mean age for CR was 40.38 ± 17.7, for CS 36.08 ± 15.12, for RS 39.72 ± 7.35 years; except 2-RCS, all studies reported gender distribution and there were 57 males and 214 females. Operating time – 3-CR, 4-CS, 9-RCS reported operating time and mean time was 111 ± 54, 131.69 ± 7.51, 117.34 ± 35.03 min respectively. Conversion rate: All studies reported data on conversion and only 4 (1.37%) cases were converted – 1 to laparoscopic approach, 3 to open approach (1-inadvertent celiac arteriotomy, 2-reasons not mentioned). Intra-operative complications: only 5-CR, 4-CS and 9-RCS reported data on intra-operative complications and there were only 6 complications (1.5%): 1-inadvertent celiac arteriotomy converted to open; 3- unnamed vascular injuries (2 managed robotically, 1-converted to open); 1-bleeding managed robotically; There were no other reported injuries. Estimated blood loss ranged from 5-30ml. Post-operative complications: 5-CR, 4-CS, 8-RCS described post-operative complications in 21 (7%) patients. 20 cases were grade I, 1 was grade IIIa and all managed successfully. LoS stay: 2-CR, 4-CS, 10-RCS reported LoS and overall, it was 2 days. R-MALR is reasonable, technically feasible, safe and has acceptable outcomes. Additionally robotic approach provided superior vision, improved dexterity, precise and easy circumferential dissection. PROSPERO registration: the protocol was registered in the PROSPERO database (CRD42024502792).
Nonlinear Finite Element Analysis of Equivalent Iwan Model Considering Threaded Connections
Authors: Sun Litai , Li Ling , Gao Xiaochan 
Published: July 2024

Abstract

Aiming at the complex geometric nonlinearity of the threaded connection and its contact behavior, a finite element model equivalent to the Iwan model is constructed for nonlinear analysis of the threaded connection. Firstly, the subroutine of the equivalent Iwan model is constructed to simulate the nonlinear contact behavior of the threaded connection; then, the finite element model of the threaded connection is constructed in Abaqus software to simulate the relationship between the torque and the preload force of the threads during tightening, and the accuracy and nonlinearity are verified with the theoretical model; finally, the influences of the coefficient of friction and the rotational amplitude on the mechanical response of the threaded connection are explored. The results show that the finite element model based on the Iwan model can accurately capture the contact behavior of the threaded joint; the increase of the friction coefficient will increase the friction between the contact surfaces, which will increase the preload force, but it may also increase the stress concentration and the risk of deformation; the increase of the rotational amplitude can increase the preload force, but it may also lead to the stress concentration and increase the risk of plastic deformation of the structure.
Efficacy of the combination of transcutaneous tibial nerve stimulation(TTNS) and mirabegron in women with overactive bladder: a prospective randomized controlled trial
Authors: Xu Ya-Xiong , Xiong Yu , Tian Hong-qiang , Yang Yan-hao , Tao Rong-zhen , Li Yun-Peng 
Published: July 2024

Abstract

Objective: The management of overactive bladder (OAB) in women encompasses a range of strategies, from behavioral modifications to pharmacotherapy and nerve stimulation techniques. This prospective, randomized, controlled trial evaluates the efficacy of the combination of TTNS and mirabegron in symptom improvement over three months in women diagnosed with OAB.
Patients and Methods: The study was designed as a randomized controlled trial. A total of 40 patients were prospectively randomized into two groups. Twenty patients in the combination group accepted TTNS and mirabegron therapy, and the other 20 patients as control only accepted mirabegron therapy. Primary outcomes were changes from baseline in the lower urinary tract symptoms. The severity of symptoms and quality of life (QoL) were assessed using the validated OAB questionnaire (OAB-q).
Results: TTNS reduced the clinical symptoms of OAB, and the difference was statistically significant at all study sites (p<0.05). Regarding secondary outcomes, the OAB-q symptom bother score was lower in the combination group than in the mirabegron group (p<0.05). The OAB-q score in the combination group was statistically superior to that in the mirabegron group (p<0.05). The incidence of complications was not statistically significant between the two groups.
Conclusion: The combination of TTNS and mirabegron represents a promising therapeutic strategy for women with overactive bladder, significantly improving symptoms and quality of life with a favorable safety profile. Further research with a larger sample size and long-term follow-up is warranted to confirm these findings and explore the underlying mechanisms of this combination therapy’s efficacy.