bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domain Specificity of MAP3K Family Members, MLK and Tak1, for JNK Signaling inDrosophila
Authors: Stronach Beth , Lennox Ashley L , Garlena Rebecca A 
Published: January 2014

AbstractA highly diverse set of protein kinases functions as early responders in the mitogen- and stress-activated protein kinase (MAPK/SAPK) signaling pathways. For instance, humans possess 14 MAPK kinase kinases (MAP3Ks) that activate Jun kinase (JNK) signaling downstream. A major challenge is to decipher the selective and redundant functions of these upstream MAP3Ks. Taking advantage of the relative simplicity of Drosophila melanogaster as a model system, we assessed MAP3K signaling specificity in several JNK-dependent processes during development and stress response. Our approach was to generate molecular chimeras between two MAP3K family members, the mixed lineage kinase, Slpr, and the TGF-β activated kinase, Tak1, which share 32% amino acid identity across the kinase domain but otherwise differ in sequence and domain structure, and then test the contributions of various domains for protein localization, complementation of mutants, and activation of signaling. We found that overexpression of the wild-type kinases stimulated JNK signaling in alternate contexts, so cells were capable of responding to both MAP3Ks, but with distinct outcomes. Relative to wild-type, the catalytic domain swaps compensated weakly or not at all, despite having a shared substrate, the JNK kinase Hep. Tak1 C-terminal domain-containing constructs were inhibitory in Tak1 signaling contexts, including tumor necrosis factor-dependent cell death and innate immune signaling; however, depressing antimicrobial gene expression did not necessarily cause phenotypic susceptibility to infection. These same constructs were neutral in the context of Slpr-dependent developmental signaling, reflecting differential subcellular protein localization and by inference, point of activation. Altogether, our findings suggest that the selective deployment of a particular MAP3K can be attributed in part to its inherent sequence differences, cellular localization, and binding partner availability.
Analysis of Crystalline in GaN Epitaxial Layer after the Wafer Dicing Process
Authors: Taguchi Hideyuki , Kitahara Amane , Miyake Shugo , Nakaue Akimitu , Fujiwara Yasufumi 
Published: January 2014

ABSTRACTThe crystallinity of a GaN epitaxial layer on a sapphire substrate after the mechanical ding process was estimated by transmission electron microscopy (TEM) and Raman spectroscopic analysis. TEM observation results showed that, the screw dislocations as a threading dislocation were induced by the mechanical dicing process in the limited area up to approximately 1.2 μm from the dicing-line. On the other hand, the crystal strains were up to approximately 7 μm from the dicing-line edge measured by the Raman spectroscopic analysis. The distance difference between the area of the screw dislocations and of the residual strain is caused by the stress relaxation.
Submicron displacement measurements of MEMS using optical microphotographs in aqueous media: Enhancement using color image processing
Authors: Warnat Stephan , King Hunter , Schwartz Rachael , Kujath Marek , Hubbard Ted 
Published: January 2014

ABSTRACTThe measurement of precise submicron displacements is essential in several MEMS applications. For instance, the measurement of the mechanical parameters of biological cells requires repeatable measurement of displacements in the nanometer regime. This paper presents a method to make displacement measurements in an aqueous MEMS environment with a ± 10 nm accuracy by using the blue channel of RGB pictures in combination with a FFT phase shift analysis.
Gender Disparities in HIV Treatment Outcomes Following Release From Jail: Results From a Multicenter Study
Authors: Meyer Jaimie P. , Zelenev Alexei , Wickersham Jeffrey A. , Williams Chyvette T. , Teixeira Paul A. , Altice Frederick L. 
Published: January 2014

Objectives. We assessed gender differences in longitudinal HIV treatment outcomes among HIV-infected jail detainees transitioning to the community. Methods. Data were from the largest multisite prospective cohort study of HIV-infected released jail detainees (n = 1270)—the Enhancing Linkages to HIV Primary Care and Services in Jail Setting Initiative, January 2008 and March 2011, which had 10 sites in 9 states. We assessed baseline and 6-month HIV treatment outcomes, stratifying by gender. Results. Of 867 evaluable participants, 277 (31.9%) were women. Compared with men, women were more likely to be younger, non-Hispanic White, married, homeless, and depressed, but were similar in recent alcohol and heroin use. By 6 months postrelease, women were significantly less likely than men to experience optimal HIV treatment outcomes, including (1) retention in care (50% vs 63%), (2) antiretroviral therapy prescription (39% vs 58%) or optimal antiretroviral therapy adherence (28% vs 44%), and (3) viral suppression (18% vs 30%). In multiple logistic regression models, women were half as likely as men to achieve viral suppression. Conclusions. HIV-infected women transitioning from jail experience greater comorbidity and worse HIV treatment outcomes than men. Future interventions that transition people from jail to community-based HIV clinical care should be gender-specific.
Medicaid Policies and Practices in US State Prison Systems
Authors: Rosen David L. , Dumont Dora M. , Cislo Andrew M. , Brockmann Bradley W. , Traver Amy , Rich Josiah D. 
Published: January 2014

Medicaid is an important source of health care coverage for prison-involved populations. From 2011 to 2012, we surveyed state prison system (SPS) policies affecting Medicaid enrollment during incarceration and upon release; 42 of 50 SPSs participated. Upon incarceration, Medicaid benefits were suspended in 9 (21.4%) SPSs and terminated in 28 (66.7%); 27 (64.3%) SPSs screened prisoners for potential Medicaid eligibility. Although many states supported Medicaid enrollment upon release, several did not. We have considered implications for Medicaid expansion.
Work Organization and Health Among Immigrant Women: Latina Manual Workers in North Carolina
Authors: Arcury Thomas A. , Grzywacz Joseph G. , Chen Haiying , Mora Dana C. , Quandt Sara A. 
Published: January 2014

Objectives. We sought to describe work organization attributes for employed immigrant Latinas and determine associations of work organization with physical health, mental health, and health-related quality of life.Methods. We conducted a cross-sectional survey with 319 employed Latinas in western North Carolina (2009–2011). Measures included job demands (heavy load, awkward posture, psychological demand), decision latitude (skill variety, job control), support (supervisor control, safety climate), musculoskeletal symptoms, mental health (depressive symptoms), and mental (MCS) and physical component score (PCS) health-related quality of life.Results. Three fifths reported musculoskeletal symptoms. Mean scores for depression, MCS, and PCS were 6.2 (SE = 0.2), 38.3 (SE = 0.5), and 42.8 (SE = 0.3), respectively. Greater job demands (heavy load, awkward posture, greater psychological demand) were associated with more musculoskeletal and depressive symptoms and worse MCS. Less decision latitude (lower skill variety, job control) was associated with more musculoskeletal and depressive symptoms. Greater support (supervisor’s power and safety climate) was associated with fewer depressive symptoms and better MCS.Conclusions. Work organization should be considered to improve occupational health of vulnerable women workers. Additional research should delineate the links between work organization and health among vulnerable workers.
Parental Incarceration and Child Mortality in Denmark
Authors: Wildeman Christopher , Andersen Signe Hald , Lee Hedwig , Karlson Kristian Bernt 
Published: January 2014

Objectives. We used Danish registry data to examine the association between parental incarceration and child mortality risk. Methods. We used a sample of all Danish children born in 1991 linked with parental information. We conducted discrete-time survival analysis separately for boys (n = 30 146) and girls (n = 28 702) to estimate the association of paternal and maternal incarceration with child mortality, controlling for parental sociodemographic characteristics. We followed the children until age 20 years or death, whichever came first. Results. Results indicated a positive association between paternal and maternal imprisonment and male child mortality. Paternal imprisonment was associated with lower child mortality risks for girls. The relationship between maternal imprisonment and female child mortality changed directions depending on the model, suggesting no clear association. Conclusions. These results indicate that the incarceration of a parent may influence child mortality but that it is important to consider the gender of both the child and the incarcerated parent.
Suicidal Ideation Among Community-Dwelling Adults in the United States
Authors: Han Beth , McKeon Richard , Gfroerer Joe 
Published: January 2014

Objectives. We examined the prevalence and correlates of past-year suicidal ideation among US community-dwelling adults. Methods. We examined data from 183 100 persons aged 18 years or older (including 9800 sampled adults with past-year suicidal ideation) who participated in the 2008–2011 National Survey on Drug Use and Health. We applied descriptive analyses and pooled and stratified (by age and major depression) multivariate logistic regression models. Results. The prevalence of past-year suicidal ideation among younger adults (6.6% among those aged 18–25 years and 4.0% among those aged 26–49 years) was higher than was that among adults aged 50 years or older (2.5%). The prevalence of suicidal ideation was high among adults with major depression (26.3%), adults with both major depression and substance use disorder (37.7%), and adults who received mental health treatment but perceived unmet treatment need (33.5%). Conclusions. Many risk and protective factors of suicidal ideation are dynamic and vary by age or major depression. These results have important implications for developing specific suicide prevention strategies that help screen, assess, and treat suicidal adults at the earliest possible time.
Medical Marijuana Laws and Suicides by Gender and Age
Authors: Anderson D. Mark , Rees Daniel I. , Sabia Joseph J. 
Published: January 2014

Objectives. We estimated the association between legalizing medical marijuana and suicides.Methods. We obtained state-level suicide data from the National Vital Statistics System’s Mortality Detail Files for 1990–2007. We used regression analysis to examine the association between medical marijuana legalization and suicides per 100 000 population.Results. After adjustment for economic conditions, state policies, and state-specific linear time trends, the association between legalizing medical marijuana and suicides was not statistically significant at the .05 level. However, legalization was associated with a 10.8% (95% confidence interval [CI] = −17.1%, −3.7%) and 9.4% (95% CI = −16.1%, −2.4%) reduction in the suicide rate of men aged 20 through 29 years and 30 through 39 years, respectively. Estimates for females were less precise and sensitive to model specification.Conclusions. Suicides among men aged 20 through 39 years fell after medical marijuana legalization compared with those in states that did not legalize. The negative relationship between legalization and suicides among young men is consistent with the hypothesis that marijuana can be used to cope with stressful life events. However, this relationship may be explained by alcohol consumption. The mechanism through which legalizing medical marijuana reduces suicides among young men remains a topic for future study.
Associations Between Driving Performance and Engaging in Secondary Tasks: A Systematic Review
Authors: Ferdinand Alva O. , Menachemi Nir 
Published: January 2014

We conducted a systematic review and meta-analysis of the literature examining the relationship between driving performance and engaging in secondary tasks. We extracted data from abstracts of 206 empirical articles published between 1968 and 2012 and developed a logistic regression model to identify correlates of a detrimental relationship between secondary tasks and driving performance. Of 350 analyses, 80% reported finding a detrimental relationship. Studies using experimental designs were 37% less likely to report a detrimental relationship (P = .014). Studies examining mobile phone use while driving were 16% more likely to find such a relationship (P = .009). Quasi-experiments can better determine the effects of secondary tasks on driving performance and consequently serve to inform policymakers interested in reducing distracted driving and increasing roadway safety.
Change in Walking and Body Mass Index Following Residential Relocation: The Multi-Ethnic Study of Atherosclerosis
Authors: Hirsch Jana A. , Diez Roux Ana V. , Moore Kari A. , Evenson Kelly R. , Rodriguez Daniel A. 
Published: January 2014

Objectives. We investigated whether moving to neighborhoods with closer proximity of destinations and greater street connectivity was associated with more walking, a greater probability of meeting the “Every Body Walk!” campaign goals (≥ 150 minutes/week of walking), and reductions in body mass index (BMI). Methods. We linked longitudinal data from 701 participants, who moved between 2 waves of the Multi-Ethnic Study of Atherosclerosis (2004–2012), to a neighborhood walkability measure (Street Smart Walk Score) for each residential location. We used fixed-effects models to estimate if changes in walkability resulting from relocation were associated with simultaneous changes in walking behaviors and BMI. Results. Moving to a location with a 10-point higher Walk Score was associated with a 16.04 minutes per week (95% confidence interval [CI] = 5.13, 29.96) increase in transport walking, 11% higher odds of meeting Every Body Walk! goals through transport walking (adjusted odds ratio = 1.11; 95% CI = 1.02, 1.21), and a 0.06 kilogram per meters squared (95% CI = −0.12, −0.01) reduction in BMI. Change in walkability was not associated with change in leisure walking. Conclusions. Our findings illustrated the potential for neighborhood infrastructure to support health-enhancing behaviors and overall health of people in the United States.
Older Adults' Perceived Challenges With Health Care Providers Treating Their Type 2 Diabetes and Comorbid Conditions
Authors: Beverly Elizabeth A. , Wray Linda A. , Chiu Ching-Ju , LaCoe Cynthia L. 
Published: January 2014

IN BRIEF
Type 2 diabetes and comorbidity represent serious health problems to the aging population. This qualitative study aimed to describe older adults' perceived challenges with providers treating their type 2 diabetes and other chronic conditions. Older adults perceived a general unwillingness from their providers to treat their multiple health conditions and address their individual preferences for care. Older adults may require more in-depth communication with their providers in addition to individualized treatment plans that address their preferences for comorbidity management.
Feasibility of depopulation of a large feedlot during a foot-and-mouth disease outbreak
Authors: McReynolds Sara W. , Sanderson Michael W. 
Published: January 2014

Abstract
Objective—To examine the feasibility of depopulation of a large feedlot during a foot-and-mouth disease (FMD) outbreak in the United States.
Design—Delphi survey followed by facilitated discussion.
Sample—27 experts, including veterinary toxicologists and pharmacologists, animal welfare experts, feedlot managers, and consulting veterinarians.
Procedures—4 veterinary pharmacologists, 5 veterinary toxicologists, 4 animal welfare experts, 26 consulting veterinarians, and 8 feedlot managers were invited to participate in a Delphi survey to identify methods for depopulation of a large feedlot during an FMD outbreak. A facilitated discussion that included 1 pharmacologist, 1 toxicologist, 1 animal welfare expert, 2 consulting veterinarians, and 2 feedlot managers was held to review the survey results.
Results—27 of 47 invited experts participated in the Delphi survey. Survey consensus was that, although several toxic agents would effectively cause acute death in a large number of animals, all of them had substantial animal welfare concerns. Pentobarbital sodium administered IV was considered the most effective pharmacological agent for euthanasia, and xylazine was considered the most effective sedative. Animal welfare concerns following administration of a euthanasia solution IV or a penetrating captive bolt were minimal; however, both veterinarians and feedlot managers felt that use of a captive bolt would be inefficient for depopulation. Veterinarians were extremely concerned about public perception, human safety, and timely depopulation of a large feedlot during an FMD outbreak.
Conclusions and Clinical Relevance—Depopulation of a large feedlot during an FMD outbreak would be difficult to complete in a humane and timely fashion.
Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas
Authors: Zink M. Christine , Farhoody Parvene , Elser Samra E. , Ruffini Lynda D. , Gibbons Tom A. , Rieger Randall H. 
Published: January 2014

Abstract
Objective—To investigate associations between age at gonadectomy and estimated risk or age at diagnosis of neoplastic and behavioral disorders in Vizslas.
Design—Retrospective cohort study.
Animals—2,505 Vizslas born between 1992 and 2008.
Procedures—Data on demographics, gonadectomy status, and age at diagnosis of disease or disorder were obtained with an anonymous online survey and analyzed.
Results—Dogs gonadectomized at ≤ 6 months, between 7 and 12 months, or at > 12 months of age had significantly increased odds of developing mast cell cancer, lymphoma, all other cancers, all cancers combined, and fear of storms, compared with the odds for sexually intact dogs. Females gonadectomized at ≤ 12 months of age and males and females gonadectomized at > 12 months of age had significantly increased odds of developing hemangiosarcoma, compared with the odds for sexually intact dogs. Dogs gonadectomized at ≤ 6 months of age had significantly increased odds of developing a behavioral disorder. The younger the age at gonadectomy, the earlier the mean age at diagnosis of mast cell cancer, cancers other than mast cell, hemangiosarcoma, lymphoma, all cancers combined, a behavioral disorder, or fear of storms.
Conclusions and Clinical Relevance—Additional studies are needed on the biological effects of removing gonadal hormones and on methods to render dogs infertile that do not involve gonadectomy. Veterinarians should discuss the benefits and possible adverse effects of gonadectomy with clients, giving consideration to the breed of dog, the owner's circumstances, and the anticipated use of the dog.
Use of pooled protozoal cultures of preputial scraping samples obtained from bulls for the detection of Tritrichomonas foetus by means of a real-time polymerase chain reaction assay
Authors: Guerra Alvaro García , Hill Janet E. , Campbell John , Waldner Cheryl L. , Hendrick Steven H. 
Published: January 2014

Abstract
Objective—To determine the sensitivity of a real-time PCR assay for the detection of Tritrichomonas foetus in protozoal cultures of preputial scraping samples pooled from up to 25 bulls and to determine the specificity of that assay for detection of T foetus in cultures for individual animals.
Design—Cross-sectional study.
Animals—188 bulls and 150 steers.
Procedures—Preputial scraping samples were collected, placed in a culture kit, and incubated at 37°C for 7 days. Cultures for individual animals were tested for T foetus by means of a real-time PCR assay. Pools of protozoal cultures were made by including fixed aliquots of samples with known positive and negative results in ratios of 1:2, 1:3, 1:5, 1:10, 1:15, 1:20, and 1:25. Specificities of the real-time PCR assay and culture for detection of T foetus in samples obtained from individual animals and sensitivity of real-time PCR assay for each evaluated pool ratio were determined.
Results—Specificity estimates for culture and the real-time PCR assay for detection of T foetus in preputial scraping samples for individual animals were not significantly different (98.8% and 100%, respectively). Sensitivities of the real-time PCR assay for the various pooled samples with known positive and negative T foetus results were not significantly different; overall sensitivity of the assay was 94%.
Conclusions and Clinical Relevance—Results indicated the evaluated real-time PCR assay had high specificity and good sensitivity for the detection of T foetus in pooled protozoal cultures of preputial scraping samples obtained from up to 25 animals.
Effects of dissolved metal chlorides on the behavior of silica nanoparticles in aqueous media
Authors: Gun’ko Vladimir , Andriyko Lyudmyla , Zarko Vladimir , Marynin Andrij , Olishevskyi Valentyn , Janusz Wladyslaw 
Published: January 2014

Abstract
Effects of chlorides of univalent (LiCl, NaCl, KCl), bivalent (MgCl2, BaCl2) and trivalent (AlCl3) metals at different concentration (0.001–0.1 M) on the behavior of nanosilica A-200 (0.5–5 wt.%) in aqueous media are analyzed using photon correlation spectroscopy (particle size distribution, PSD), electrophoresis (zeta potential ζ), potentiometric titration (surface charge density), and estimation of screening length of primary particles and their aggregates. The zeta potential and the PSD are affected by silica content, pH, and concentration and type of dissolved salts. Smaller but more strongly hydrated Li+ cations caused stronger nonlinear dependences of the zeta potential on pH and salt content than Na+ or K+. This nonlinearity is much stronger at a lower content of silica (0.5–1 wt.%) than at C
A-200 = 2.5 or 5 wt.%. At a high concentration of nanosilica (5 wt.%) the effect of K+ ions causes stronger diminution of the negative value of the zeta potential due to better adsorption of larger cations. Therefore, the influence of K+ on increasing screening length is stronger than that of Na+ for both primary nanoparticles and their aggregates. A similar difference in the ζ values is observed for different in size cations Ba2+ and Mg2+.
Integration over homogeneous spaces for classical Lie groups using iterated residues at infinity
Authors: Zielenkiewicz Magdalena 
Published: January 2014

Abstract
Using the Berline-Vergne integration formula for equivariant cohomology for torus actions, we prove that integrals over Grassmannians (classical, Lagrangian or orthogonal ones) of characteristic classes of the tautological bundle can be expressed as iterated residues at infinity of some holomorphic functions of several variables. The results obtained for these cases can be expressed as special cases of one formula involving the Weyl group action on the characters of the natural representation of the torus.