bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining Injection Molding and 3D Printing for Tailoring Polymer Material Properties
Authors: Vigogne Michelle , Zschech Carsten , Stommel Markus , Thiele Julian , Kühnert Ines 
Published: August 2024

AbstractModern polymer‐based technical components not only have to fulfill demanding mechanical‐structural properties but need to integrate different functions to yield hybrid systems for complex operations. Typically, neither materials nor processing technologies are fully compatible with each other. The aim of the work is to combine the advantages of seemingly incompatible manufacturing processes such as high‐volume injection molding (IM) and precision additive manufacturing to produce functional and customized hybrid materials. IM is widely used for polymer processing but stands against high investment costs for tailor‐made molds with high‐resolution features. They focus on overprinting of injection‐molded parts made of thermoplastic polyurethane (TPU) with microstructures via projection‐microstereolithography (PµSL) to generate hybrid polymer materials with spatially tailored stiffness, enabling selective reinforcement, resulting in an E modulus increase of 195% compared to mere IM‐processed TPU. With that, the hybridization of processing methods is showcased to extend the product properties of polymer materials obtained via either IM or PµSL printing that have, prospectively, a maximum degree of individualization as well as a multitude of structural and functional features at the same time. To achieve optimum interfacial adhesion, the influence of surface roughness is studied, and reinforcement effects of different overprinted microstructure types are evaluated.
Bayesian inference and consumer behavioral theory
Authors: Hofacker Charles F. , Nguyen Huong N. L. , Fina Matteo 
Published: August 2024

AbstractWith this article we hope to achieve two goals. The first is to encourage consumer behavioral researchers to consider Bayesian methods for analyzing experimental and survey data. As such, we provide what we hope will be a persuasive set of arguments for trying Bayes. The second goal is to survey the different uses to which the Bayesian posterior distribution can be put. We organize this survey in terms of loss functions and propose that such loss functions can be chosen so as to simply describe a consumer behavioral phenomenon, to highlight a managerial implication, or to emphasize a theoretical contribution.
Hereditary breast cancer next‐generation sequencing panel evaluation in the south region of Brazil: A novel BRCA2 candidate pathogenic variant is reported
Authors: Duarte Cesar Augusto B. , dos Santos Carlos Alberto , de Oliveira Cristine Domingues D. , Spautz Cleverton César , Sumita Laura Masami , Nakatani Sueli Massumi 
Published: August 2024

AbstractBackgroundIn this article, we delineate a loosely selected cohort comprising patients with a history of early‐onset breast cancer and/or a familial occurrence of cancer. The aim of this study was to gain insights into the presence of breast cancer‐related gene variants in a population from a micro‐region in southern Brazil, specifically the Metropolitan Region of Curitiba. This area exhibits a highly genetically mixed population, mirroring the general characteristics of the Brazilian people.MethodsComprehensive next‐generation sequencing (NGS) multigene panel testing was conducted on 12 patients from the region, utilizing three different library preparation methods.ResultsTwo pathogenic variants and one candidate pathogenic variant were identified: BRCA2 c.8878C>T, p.Gln2960Ter; CHEK2 c.1100del, p.Thr367Metfs15, and BRCA2 c.3482dup, p.Asp1161Glufs3.ConclusionBRCA2 c.3482dup, a novel candidate pathogenic variant, previously unpublished, is reported. The prevalence of pathogenic variants in this small cohort is similar to that described in the literature. All different library preparation methods were equally proficient in enabling the detection of these variants.
Effect of Alcohol on Clock Synchrony and Tissue Circadian Homeostasis in Mice
Authors: Santovito Luca S. , Shaikh Maliha , Sharma Deepak , Forsyth Christopher B. , Voigt Robin M. , Keshavarzian Ali , Bishehsari Faraz 
Published: August 2024

AbstractAlcohol use disorder accounts for a growing worldwide health system concern. Alcohol causes damages to various organs, including intestine and liver, primarily involved in its absorption and metabolism. However, alcohol‐related organ damage risk varies significantly among individuals, even when they report consuming comparable dosages of alcohol. Factor(s) that may modulate the risk of organ injuries from alcohol consumption could be responsible for inter‐individual variations in susceptibility to alcohol‐related organ damages. Accumulating evidence suggests disruptions in circadian rhythm can exacerbate alcohol‐related organ damages. Here we investigated the interplay between alcohol, circadian rhythm, and key tissue cellular processes at baseline, after a regular and a shift in the light/dark cycle (LCD) in mice. Central/peripheral clock expression of core clock genes (CoClGs) was analyzed. We also studied circadian homeostasis of tissue cellular processes that are involved in damages from alcohol. These experiments reveal that alcohol affects the expression of CoClGs causing a central‐peripheral dyssynchrony, amplified by shift in LCD. The observed circadian clock dyssynchrony was linked to circadian disorganization of key processes involved in the alcohol‐related damages, particularly when alcohol was combined with LCD. These results offer insights into the mechanisms by which alcohol interacts with circadian rhythm disruption to promote organ injury.
Does COVID‐19 Related Lockdown Restrictions Impact People With Musculoskeletal Disorders? A Systematic Review
Authors: Fatoye Francis , Fatoye Clara , Lawoe Joyceline , Mbada Chidozie , Gebrye Tadesse 
Published: August 2024

ABSTRACTBackgroundAs a result of coronavirus disease 2019 (COVID‐19) related lockdown restrictions, people with musculoskeletal (MSK) disorders could be at increased risk of physical and psychological disabilities. This review aimed to summarise the impact of COVID‐19 related lockdown restrictions on people with MSK disorders.MethodsSix electronic databases were searched for studies in the English language published until June 10, 2024. We used the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses to identify, select, and critically appraise relevant research. Two reviewers independently abstracted data from the included studies. Data were summarised using narrative synthesis, and the Newcastle–Ottawa Scale was used for quality assessment.ResultsThe search strategy identified 637 articles, 129 of which were removed as duplicates. Fifteen studies that met the inclusion criteria were analysed. The sample size the studies reviewed ranged from 40 to 1800. Having MSK disorders during COVID‐19 related lockdown restrictions led to increased risk of pain, stress, depression, anxiety, MSK related injuries, decreased quality of life and increased use of emergency department.ConclusionsThis is the first study to report that COVID‐19 related lockdown restrictions led to increased risk of pain, MSK injuries and healthcare resource utilisation as well as decreased quality of life among patients with MSK disorders. These results may help inform policy and management strategies in future for people with MSK disorders to mitigate the negative impact of pandemic.
A condition number‐based numerical stabilization method for geometrically nonlinear topology optimization
Authors: Scherz Lennart , Kriegesmann Benedikt , Pedersen Claus B. W. 
Published: August 2024

AbstractThe current paper introduces a new stabilization scheme for void and low‐density elements for geometrical nonlinear topology optimization. Frequently, certain localized regions in the geometrical nonlinear finite element analysis of the topology optimization have excessive artificial distortions due to the low stiffness of the void and low‐density elements. The present stabilization applies a hyperelastic constitutive material model for the numerical stabilization that is associated with the condition number of the deformation gradient and thereby, is associated with the numerical conditioning of the mapping between current configuration and reference configuration of the underlying continuum mechanics on a constitutive material model level. The stabilization method is independent upon the topology design variables during the optimization iterations. Numerical parametric studies show that the parameters for the constitutive hyperelasticity material of the new stabilization scheme are governed by the stiffness of the constitutive model of the initial physical system. The parametric studies also show that the stabilization scheme is independently upon the type of constitutive model of the physical system and the element types applied for the finite element modeling. The new stabilization scheme is numerical verified using both academic reference examples and industrial applications. The numerical examples show that the number of optimization iterations is significantly reduced compared to the stabilization approaches previously reported in the literature.
Campus agricultural projects: The missions that enhance institutions of higher education
Authors: Biang JoHannah H. , Berle David C. , Thompson Jennifer Jo 
Published: August 2024

AbstractCampus farms and gardens, or campus agricultural projects (CAPs), are a growing phenomenon across the United States. While this phenomenon is not novel, the documentation of its contributions is. In response to this dearth of knowledge, this work analyzes the mission and purpose of CAPs to understand their contributions to institutions of higher education and their surrounding communities. Using the mission statements of CAPs online and drawing from content analysis, we use web‐based data to qualitatively analyze their missions and aims. We find that CAPs aim to enhance their institutions of higher education through the main themes of student development, community engagement, campus community engagement, and sustainability. Several under‐recognized themes such as sharing culture/tradition, increasing well‐being, and promoting inclusivity emerged from this work. These resulting themes show that CAPs are not only sites where students learn to grow food but where they connect to grow themselves and their communities.
Impact of Tracheostomy Status on Sternal Wound Infections in Children Following Median Sternotomy
Authors: Nallani Rohit , Miller Brevin J. , Noel‐MacDonnell Janelle R. , Tracy Meghan , Brown Jason R. , O'Brien James E. , Jensen Daniel R. 
Published: August 2024

AbstractObjectiveSternal wound infection (SWI) is a rare but potentially life‐threatening complication in children following sternotomy. Risk factors include young age, extended preoperative hospitalization, and prolonged ventilatory support. Few studies have explored the impact of pre‐existing tracheostomy on SWI in pediatric patients. The purpose of this study is to measure the effect of tracheostomy and other factors on SWI in children undergoing sternotomy.Study DesignRetrospective cohort study of a 12 year period.SettingTertiary children's hospital.MethodsChildren with a tracheostomy prior to sternotomy (TPS) were identified and matched by age, height, and weight to children who underwent sternotomy alone. Demographics, medical comorbidities, surgical details, SWI diagnosis and management information, and surgical outcomes were collected.ResultsWe identified 60 unique individuals representing 80 sternotomies. The incidence of SWI was 22.5% (n = 9) in children with a tracheostomy and 2.5% (n = 1) in those without. The incidence of SWI was greater in children with a tracheostomy (90% vs 10% in those without, P = .007) and underlying pulmonary disease (90% vs 10% in those without, P = .020). Infections in the TPS group also demonstrated greater frequency of Pseudomonas aeruginosa (n = 3) and polymicrobial growth (n = 2).ConclusionThe risk of developing a SWI in children undergoing sternotomy is significantly greater in those with a tracheostomy and underlying pulmonary disease. Further study is needed to understand other contributing factors and ways to mitigate this risk.
TermineR: Extracting information on endogenous proteolytic processing from shotgun proteomics data
Authors: Cosenza‐Contreras Miguel , Seredynska Adrianna , Vogele Daniel , Pinter Niko , Brombacher Eva , Cueto Ruth Fiestas , Dinh Thien‐Ly Julia , Bernhard Patrick , Rogg Manuel , Liu Junwei , Willems Patrick , Stael Simon , Huesgen Pitter F. , Kuehn E. Wolfgang , Kreutz Clemens , Schell Christoph , Schilling Oliver 
Published: August 2024

AbstractState‐of‐the‐art mass spectrometers combined with modern bioinformatics algorithms for peptide‐to‐spectrum matching (PSM) with robust statistical scoring allow for more variable features (i.e., post‐translational modifications) being reliably identified from (tandem‐) mass spectrometry data, often without the need for biochemical enrichment. Semi‐specific proteome searches, that enforce a theoretical enzymatic digestion to solely the N‐ or C‐terminal end, allow to identify of native protein termini or those arising from endogenous proteolytic activity (also referred to as “neo‐N‐termini” analysis or “N‐terminomics”). Nevertheless, deriving biological meaning from these search outputs can be challenging in terms of data mining and analysis. Thus, we introduce TermineR, a data analysis approach for the (1) annotation of peptides according to their enzymatic cleavage specificity and known protein processing features, (2) differential abundance and enrichment analysis of N‐terminal sequence patterns, and (3) visualization of neo‐N‐termini location. We illustrate the use of TermineR by applying it to tandem mass tag (TMT)‐based proteomics data of a mouse model of polycystic kidney disease, and assess the semi‐specific searches for biological interpretation of cleavage events and the variable contribution of proteolytic products to general protein abundance. The TermineR approach and example data are available as an R package at https://github.com/MiguelCos/TermineR.
Diabetic retinopathy from the vitreous proteome perspective: The INSC94Y transgenic pig model study
Authors: Degroote Roxane L. , Schmalen Adrian , Renner Simone , Wolf Eckhard , Hauck Stefanie M. , Deeg Cornelia A. 
Published: August 2024

AbstractINSC94Y transgenic pigs represent a model for mutant insulin gene‐induced diabetes of youth, with impaired insulin secretion and beta cell loss, leading to elevated fasting blood glucose levels. A key complication of diabetes mellitus is diabetic retinopathy (DR), characterized by hyperglycemia‐induced abnormalities in the retina. Adjacent to the retina lies the vitreous, a gelatinous matrix vital for ocular function. It harbors proteins and signaling molecules, offering insights into vitreous biology and ocular health. Moreover, as a reservoir for secreted molecules, the vitreous illuminates molecular processes within intraocular structures, especially under pathological conditions. To uncover the proteomic profile of porcine vitreous and explore its relevance to DR, we employed discovery proteomics to compare vitreous samples from INSC94Y transgenic pigs and wild‐type controls. Our analysis identified 1404 proteins, with 266 showing differential abundance in INSC94Y vitreous. Notably, the abundances of ITGB1, COX2, and GRIFIN were significantly elevated in INSC94Y vitreous. Gene Set Enrichment Analysis unveiled heightened MYC and mTORC1 signaling in INSC94Y vitreous, shedding light on its biological significance in diabetes‐associated ocular pathophysiology. These findings deepen our understanding of vitreous involvement in DR and provide valuable insights into potential therapeutic targets. Raw data are accessible via ProteomeXchange (PXD038198).
Potential‐temperature variance budget in a saturated coastal‐fog environment
Authors: Barbano Francesco , Pardyjak Eric 
Published: August 2024

AbstractIn this work, we explore the intricacies of the potential‐temperature variance budget in coastal fog. We propose an improvement to the theoretical framework of the budget, whereby we include the heat exchange due to water‐phase changes. We then show this framework's consistency with a real‐world case study from the Coastal Fog (C‐FOG) Research Program. Results show that the presence of intermittent energy bursts is driven by the sudden turbulent injection of heat into the environment caused by the condensation of water vapour, and the improved theoretical framework proves satisfactory in detailing the observed process. The heat excess is transported vertically, creating a two‐term balance of high‐order moments. A bulk parametrization of this balance is also proposed to provide a simplified representation of the phase‐change process and suggest that it could be used for operational purposes. Finally, the length‐scales of the processes are evaluated from the parametrizations. The analysis indicates that the scales of the phase change of water vapour are consistent with the buoyancy production and Taylor scales.
A potential prospect: The novel treatment of intrapleural saline irrigation with intrapleural tyloxapol in treating thoracic empyema
Authors: Mohamad Jailaini Mas Fazlin , Saini Noor Amirah , Che Rahim Mohd Jazman , Abdul Hamid Mohamed Faisal 
Published: August 2024

AbstractThe treatment for empyema thoracis has been evolving over the years, including the usage of intrapleural fibrinolytic therapy (IPFT), for example, alteplase with intrapleural deoxyribonuclease (DNase) to enhance the drainage of pleural effusion. Here, we report two cases of thoracic empyema that were successfully treated with intrapleural saline irrigation and intrapleural tyloxapol apart from parenteral antibiotics as the pillar of the treatment. Both patients averted surgical procedure (decortication) and were discharged well. Upon follow‐up, both cases showed clinical cure, biochemical recovery, and radiological improvement, indicating a good treatment outcome. This is the first reported cases on combination of saline irrigation with tyloxapol as alternative treatment for pleural infection.
The Growth and Shape Evolution of Indium Nanoplates Studied by In Situ Liquid Cell TEM
Authors: Tian Jiamin , Lin Dongying , Li Xuan , Wang Kewei , Yu Bocheng , Li Menglan , Hou Shimin , Li Zhihong , Chen Qing 
Published: August 2024

AbstractUnderstanding the growth mechanisms of nanomaterials is crucial for effectively controlling their morphology which may affect their properties. Here, the growth process of indium nanoplates is studied using in situ liquid cell transmission electron microscopy. Quantitative analysis shows that the growth of indium nanoplate is limited by surface reaction. Besides, the growth process has two stages, which is different from that of other metal nanoplates reported previously. At the first stage, indium particles transform gradually from face‐centered cubic to body‐centered tetragonal (bct) structure as the seeds grow. At the second stage, the seeds grow faster than at the first stage and form indium triangular nanoplates. Indium triangular nanoplates have a bct structure with {011}‐twin, which is found to form through kinetic reactions. In addition, the shape evolution of truncated triangle nanoplate with multiple twin planes is studied. The growth rate of truncated edge changes with the varied number of re‐entrant grooves. The present work provides valuable insights into the growth mechanism of metal nanoplates with low‐symmetric structure and the role of twin planes in the shape evolution of plate‐like metal nanomaterials.
Near‐Infrared Mechanoluminescence from Cr3+‐Doped Spinel Nanoparticles for Potential Oral Diseases Detection
Authors: Shao Peishan , Chen Dongdan , Lun Zhenjie , Wu Yafen , Chen Zhicong , Xiao Yao , Xiong Puxian , Wang Shouping , Viana Bruno , Im Won Bin , Yang Zhongmin 
Published: August 2024

AbstractMechanoluminescence (ML) phosphors have found various promising utilizations such as in non‐destructive stress sensing, anti‐counterfeiting, and bio stress imaging. However, the reported NIR MLs have predominantly been limited to bulky particle size and weak ML intensity, hindering the further practical applications. For this regard, a nano‐sized ZnGa2O4: Cr3+ NIR ML phosphor is synthesized by hydrothermal method. By improving the synthesis method and regulating the chemical composition, the NIR ML (600–1000 nm) intensity of such nano‐materials has been further enhanced about four times. The reasons for the ML performance difference between micro‐/nano‐ sized phosphors also have been preliminarily analyzed. Additionally, this work probes into the ML mechanism deeply in traps’ aspect from band structure and defect formation energy, which can supply significant references for a new approach to develop efficient NIR ML nanoparticles. Finally, due to excellent tissue penetration capability, nano‐sized ZnGa2O4:Cr3+ NIR ML phosphor shows great potential applications in biomedical fields such as for the detection of clinical oral diseases.
Field‐Directed Motion, Cargo Capture, and Closed‐Loop Controlled Navigation of Microellipsoids
Authors: Gauri Hashir M. , Patel Ruchi , Lombardo Nicholas S. , Bevan Michael A. , Bharti Bhuvnesh 
Published: August 2024

AbstractMicrorobots have the potential for diverse applications, including targeted drug delivery and minimally invasive surgery. Despite advancements in microrobot design and actuation strategies, achieving precise control over their motion remains challenging due to the dominance of viscous drag, system disturbances, physicochemical heterogeneities, and stochastic Brownian forces. Here, a precise control over the interfacial motion of model microellipsoids is demonstrated using time‐varying rotating magnetic fields. The impacts of microellipsoid aspect ratio, field characteristics, and magnetic properties of the medium and the particle on the motion are investigated. The role of mobile micro‐vortices generated is highlighted by rotating microellipsoids in capturing, transporting, and releasing cargo objects. Furthermore, an approach is presented for controlled navigation through mazes based on real‐time particle and obstacle sensing, path planning, and magnetic field actuation without human intervention. The study introduces a mechanism of directing motion of microparticles using rotating magnetic fields, and a control scheme for precise navigation and delivery of micron‐sized cargo using simple microellipsoids as microbots.