bluuebunny/crossref_metadata_2025_split huggingface dataset:
Denitrification‐caused suppression of soluble microbial products (SMP) in MBRs used for biological nitrogen removal
Authors: Zhou Zhongbo , Meng Fangang , Lu Hui , Jia Xiaoshan 
Published: July 2013

SignificanceThe strategies for reducing SMP‐caused membrane fouling are essential for MBR sustainable operation. Comparing the bioprocesses with and without denitrification, we found that the specific yield coefficients of polysaccharides (PS) and proteins (PN) in SMP existing denitrification were significantly lower than those without denitrification. In addition, the freshly produced PS and PN from extracelluar polymeric substances (EPS) could be biodegraded and utilized by denitrifers. These findings indicated that biological denitrification was an important mechanism to reduce SMP and MBR fouling. © 2013 American Institute of Chemical Engineers AIChE J, 59: 3569–3573, 2013
9p partial monosomy and disorders of sex development: Review and postulation of a pathogenetic mechanism
Authors: Quinonez Shane C. , Park John M. , Rabah Raja , Owens Kailey M. , Yashar Beverly M. , Glover Thomas W. , Keegan Catherine E. 
Published: July 2013

AbstractDeletion of the distal segment of 9p causes a syndrome comprising trigonocephaly, minor anomalies, and intellectual disability. Patients with this condition also frequently present with genitourinary abnormalities including cryptorchidism, hypospadias, ambiguous genitalia, or 46,XY testicular dysgenesis. The region responsible for the gonadal dysgenesis has been localized to 9p24.3 with the likely responsible gene identified as DMRT1. Similar to patients with other molecular causes of 46,XY gonadal dysgenesis, patients with partial del 9p have an increased risk of gonadoblastoma. We present two patients with 46,XY gonadal dysgenesis due to partial 9p monosomy. Both patients were also diagnosed with gonadoblastoma following gonadectomy at an early age. Chromosomal microarray analyses refined the cytogenetic abnormalities and allowed potential genotype–phenotype relationships to be determined. We also review the literature as it pertains to partial 9p monosomy, genital abnormalities and gonadoblastoma and note that a large percentage of affected patients present with two copy number variations. We propose that a two‐hit mechanism may be involved in the incomplete penetrance and variable expressivity of partial 9p monosomy and an abnormal genital phenotype. The significant percentage of gonadoblastoma in patients with 46,XY complete gonadal dysgenesis due to partial 9p monosomy also continues to support the necessity of gonadectomy in this patient population. © 2013 Wiley Periodicals, Inc.
Microdeletions of 5.5 Mb (4q13.2–q13.3) and 4.1 Mb (7p15.3–p21.1) associated with a saethre–chotzen‐like phenotype, severe intellectual disability, and autism
Authors: Shimada Shino , Okamoto Nobuhiko , Nomura Shohei , Fukui Miho , Shimakawa Shuichi , Sangu Noriko , Shimojima Keiko , Osawa Makiko , Yamamoto Toshiyuki 
Published: July 2013

AbstractWe observed a patient with a Saethre–Chotzen‐like phenotype with severe neurological features. Saethre–Chotzen syndrome (acrocephalosyndactyly type III; SCS; OMIM #101400) is an autosomal dominant craniosynostosis syndrome characterized by craniofacial and mild limb abnormalities. The phenotypic features of chromosomal microdeletions involving the 7p21.1, where the twist homolog 1 gene (TWIST1) responsible for SCS is located, are recognized as a contiguous gene deletion syndrome with SCS and other phenotypic manifestations. In this study, we identified microdeletions in 4q13.2 and 7p21.1 in a patient with SCS and severe neurological features including developmental delay and autistic behavior. In comparison to other SCS patients with intragenic mutations or small deletions in 7p21.1, neurological features seen in this patient were extremely severe, likely modified by a concurrent deletion of 4q13.2. Both microdeletions were de novo and paternal in origin. Further information on such concurrent chromosomal deletions should be accumulated for better understanding of the mechanism. © 2013 Wiley Periodicals, Inc.
A novel ALDH5A1 mutation is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability in an Iranian family
Authors: Püttmann Lucia , Stehr Henning , Garshasbi Masoud , Hu Hao , Kahrizi Kimia , Lipkowitz Bettina , Jamali Payman , Tzschach Andreas , Najmabadi Hossein , Ropers Hans‐Hilger , Musante Luciana , Kuss Andreas W. 
Published: July 2013

AbstractSuccinic semialdehyde dehydrogenase (SSADH) deficiency is a disorder of the catabolism of the neurotransmitter gamma‐aminobutyric acid (GABA) with a very variable clinical phenotype ranging from mild intellectual disability to severe neurological defects. We report here on a large Iranian family with four affected patients presenting with severe intellectual disability, developmental delay and generalized tonic–clonic seizures. Molecular genetic analysis revealed a missense mutation c.901A>G (p.K301E, RefSeq number NM_001080) in ALDH5A1 co‐segregating with the disease in the family. The missense mutation affects an amino acid residue that is highly conserved across the animal kingdom. Protein modeling showed that p.K301E most likely leads to a loss of NAD+ binding and a predicted decrease in the free energy by 6.67 kcal/mol furthermore suggests a severe destabilization of the protein. In line with these in silico observations, no SSADH enzyme activity could be detected in patient lymphoblasts. © 2013 Wiley Periodicals, Inc.
Insertional translocation leading to a 4q13 duplication including theEPHA5gene in two siblings with attention‐deficit hyperactivity disorder
Authors: Matoso Eunice , Melo Joana B. , Ferreira Susana I. , Jardim Ana , Castelo Teresa M. , Weise Anja , Carreira Isabel M. 
Published: July 2013

AbstractAn insertional translocation (IT) can result in pure segmental aneusomy for the inserted genomic segment allowing to define a more accurate clinical phenotype. Here, we report on two siblings sharing an unbalanced IT inherited from the mother with a history of learning difficulty. An 8‐year‐old girl with developmental delay, speech disability, and attention‐deficit hyperactivity disorder (ADHD), showed by GTG banding analysis a subtle interstitial alteration in 21q21. Oligonucleotide array comparative genomic hybridization (array‐CGH) analysis showed a 4q13.1–q13.3 duplication spanning 8.6 Mb. Fluorescence in situ hybridization (FISH) with bacterial artificial chromosome (BAC) clones confirmed the rearrangement, a der(21)ins(21;4)(q21;q13.1q13.3). The duplication described involves 50 RefSeq genes including theEPHA5gene that encodes for the EphA5 receptor involved in embryonic development of the brain and also in synaptic remodeling and plasticity thought to underlie learning and memory. The same rearrangement was observed in a younger brother with behavioral problems and also exhibiting ADHD. ADHD is among the most heritable of neuropsychiatric disorders. There are few reports of patients with duplications involving the proximal region of 4q and a mild phenotype. To the best of our knowledge this is the first report of a duplication restricted to band 4q13. This abnormality could be easily missed in children who have nonspecific cognitive impairment. The presence of this behavioral disorder in the two siblings reinforces the hypothesis that the region involved could include genes involved in ADHD. © 2013 Wiley Periodicals, Inc.
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with marfan and loeys–dietz syndrome
Authors: Rienhoff Hugh Young , Yeo Chang‐Yeol , Morissette Rachel , Khrebtukova Irina , Melnick Jonathan , Luo Shujun , Leng Nan , Kim Yeon‐Jin , Schroth Gary , Westwick John , Vogel Hannes , McDonnell Nazli , Hall Judith G. , Whitman Malcolm 
Published: July 2013

AbstractThe transforming growth factor β (TGF‐β) family of growth factors are key regulators of mammalian development and their dysregulation is implicated in human disease, notably, heritable vasculopathies including Marfan (MFS, OMIM #154700) and Loeys–Dietz syndromes (LDS, OMIM #609192). We described a syndrome presenting at birth with distal arthrogryposis, hypotonia, bifid uvula, a failure of normal post‐natal muscle development but no evidence of vascular disease; some of these features overlap with MFS and LDS. A de novo mutation in TGFB3 was identified by exome sequencing. Several lines of evidence indicate the mutation is hypomorphic suggesting that decreased TGF‐β signaling from a loss of TGFB3 activity is likely responsible for the clinical phenotype. This is the first example of a mutation in the coding portion of TGFB3 implicated in a clinical syndrome suggesting TGFB3 is essential for both human palatogenesis and normal muscle growth. © 2013 Wiley Periodicals, Inc.
Nitrile‐converting enzymes: An eco‐friendly tool for industrial biocatalysis
Authors: Ramteke Pramod W. , Maurice Navodita G. , Joseph Babu , Wadher Bharat J. 
Published: July 2013

AbstractNitriles are organic compounds bearing a CN group; they are frequently known to occur naturally in both fauna and flora and are also synthesized chemically. They have wide applicability in the fields of medicine, industry, and environmental monitoring. However, the majority of nitrile compounds are considered to be lethal, mutagenic, and carcinogenic in nature and are known to cause potential health problems such as nausea, bronchial irritation, respiratory distress, convulsions, coma, and skeletal deformities in humans. Nitrile‐converting enzymes, which are extracted from microorganisms, are commonly termed nitrilases and have drawn the attention of researchers all over the world to combat the toxicity of nitrile compounds. The present review focuses on the utility of nitrile‐converting enzymes, sources, classification, structure, properties, and applications, as well as the future perspective on nitrilases.
An Xp21.3p11.4 duplication observed in a boy with intellectual deficiency and speech delay and his asymptomatic mother
Authors: Wu Lingqian , Liu Jing , Lv Weigang , Wen Juan , Xia Yan , Liang Desheng 
Published: July 2013

BACKGROUNDInterstitial Xp duplications have been rarely described, especially in males. Male patients show intellectual deficiency (ID) and variable congenital malformations depending on the size and the position of the duplication.METHODSCytogenetic and molecular analyses using standard G‐banding, R‐banding, fluorescence in situ hybridization, and an array comparative genomic hybridization analysis for copy number variation detection were performed in the propositus and his mother.RESULTSA 12,168,283 bp interstitial duplication of the Xp21.3p11.4 region was detected in the boy with ID and speech delay and his asymptomatic mother.CONCLUSIONAn Xp21.3p11.4 duplication was characterized at the molecular level in a boy with ID and speech delay. Genotype–phenotype correlations of interstitial Xp duplications were performed by comparing previously reported cases and our patient. Birth Defects Research (Part A) 97:467–470, 2013. © 2013 Wiley Periodicals, Inc.
Population Balance Modeling of the Solution‐Mediated Transformation of DL‐Methionine Polymorphs
Authors: Wantha L. , Flood A. E. 
Published: July 2013

AbstractExperimental measurements of the solution‐mediated transformation (SMT) of the metastable polymorph of DL‐methionine (α‐DL‐met) into the stable polymorph (γ‐DL‐met) in water were performed at 25 °C. These results were compared to models of the crystallization and the SMT of α‐DL‐met into γ‐DL‐met that were developed using the concept of the population balance equation (PBE) applied to both of the polymorphs. The growth, dissolution, and nucleation kinetic expressions obtained in a previous work were used in the models. It was found that the PBE models did not satisfactorily describe the SMT process of DL‐met when the measured crystallization and dissolution kinetics were used. There were large mismatches between the simulation and the experimental results. Modifying the model of the dissolution kinetics of α‐DL‐met enabled these mismatches to be lowered. The results showed that the SMT of DL‐met is controlled by the rate of dissolution of α‐DL‐met.
ChemInform Abstract: Experimental Investigation of Phase Equilibria in the Sn—V—Zn System at 450 °C and 600 °C.
Authors: Wu Changjun , Su Xuping , Liu Ya , Peng Haoping , Wang Jianhua , Tu Hao 
Published: July 2013

AbstractA series of alloys of the title system is prepared by melting (corundum crucible in evacuated quartz tube, 1000 °C, 10 h, bottom quenching to minimize Zn loss, annealing at 450 °C or 600 °C, 15—20 d) or powder metallurgical cold pressing followed by annealing (450 °C, 30 d, or 600 °C, 15 d) and quenching.
ChemInform Abstract: Mesoporous Li4Ti5O12 Hollow Spheres with Enhanced Lithium Storage Capability.
Authors: Yu Le , Wu Hao Bin , Lou Xiong Wen 
Published: July 2013

AbstractHigh‐quality Li4Ti5O12 hollow spheres with mesoporous shells of tuneable thickness are prepared from mixtures of SiO2@amorphous TiO2 spheres and LiOH in EtOH and H2O (autoclave, 160 °C, 6 h, followed by annealing at 500 °C for 4 h).
ChemInform Abstract: The Periodate‐Based Double Perovskites M2NaIO6 (M: Ca, Sr, and Ba).
Authors: Kubel Frank , Wandl Nicole , Pantazi Mariana , D'Anna Vincenza , Hagemann Hans 
Published: July 2013

AbstractThe title compounds are prepared from mixtures of MF2 (M: Ca, Sr, Ba) and NaI (Pt crucible, 650 °C, 18 h, yield given in g).
ChemInform Abstract: Synthesis, Crystal Structure, Spectrum Properties, and Electronic Structure of a New Three‐Borate Ba4Na2Zn4 (B3O6)2(B12O24) with Two Isolated Types of Blocks: 3[3Δ] and 3[2Δ + 1T].
Authors: Chen Xuean , Chen Yanjun , Sun Chong , Chang Xinan , Xiao Weiqiang 
Published: July 2013

AbstractBa4Na2Zn4 (B3O6)2(B12O24) is prepared by solid state reaction of a mixture of Na2CO3, BaCO3, ZnO, H3BO3, and Na2B4O7 in a molar ratio of 1:4:6:18:2 (Pt crucible, 750 °C, 28 d).
ChemInform Abstract: Se‐Phenyl Prop‐2‐eneselenoate: An Ethylene Equivalent for Diels—Alder Reactions.
Authors: Jung Michael E. , Perez Felix , Regan Collin F. , Yi Sung Wook , Perron Quentin 
Published: July 2013

AbstractA new ethylene equivalent for Diels—Alder cycloaddition reactions is developed.
ChemInform Abstract: Lewis Basic Selenium Catalyzed Chloroamidation of Olefins Using Nitriles as the Nucleophiles.
Authors: Tay Daniel Weiliang , Tsoi Ivan Tan , Er Jun Cheng , Leung Gulice Yiu Chung , Yeung Ying‐Yeung 
Published: July 2013

AbstractThe chloroamidation of olefins utilizes diphenyl selenide as the catalyst together with N‐chlorosuccinimide and acetonitrile as the halogen and nitrogen source and is applicable to a wide range of substrates.
ChemInform Abstract: Iodide as an Activating Agent for Acid Chlorides in Acylation Reactions.
Authors: Wakeham Russell J. , Taylor James E. , Bull Steven D. , Morris James A. , Williams Jonathan M. J. 
Published: July 2013

AbstractAcid chlorides can be activated by using simple iodide sources, e.g., KI or LiI, to undergo nucleophilic attack by a variety of relatively weak nucleophiles.
ChemInform Abstract: A Novel Catalytic Asymmetric Route Towards Skipped Dienes with a Methyl‐Substituted Central Stereogenic Carbon.
Authors: Huang Yange , Fananas‐Mastral Martin , Minnaard Adriaan J. , Feringa Ben L. 
Published: July 2013

AbstractA highly efficient method for the enantioselective synthesis of 1,4‐dienes (III) with a methyl‐substituted central carbon atom using an asymmetric allylic alkylation of diene bromides (I) is described.
ChemInform Abstract: NHC‐Catalyzed Annulation of Enals to Ene‐1,4‐diones: Stereoselective Synthesis of 1,3‐Diaryl‐4‐acyl Cyclopentenes.
Authors: Paul Rony Rajan , Lakshmi K. C. Seetha , Suresh Eringathodi , Nair Vijay 
Published: July 2013

AbstractThe optimized system is successfully applied to various aromatic diketones and aldehydes to produce highly functionalized trans‐cyclopentene structures.
ChemInform Abstract: Iron‐Catalyzed Allylic Arylation of Olefins via C(sp3)—H Activation under Mild Conditions.
Authors: Sekine Masaki , Illies Laurean , Nakamura Eiichi 
Published: July 2013

AbstractThe lack of selectivity in hydrogen abstraction and the consumption of the Grignard reagent for catalyst generation accounting for the modest yields are the main drawbacks of the presented method.
ChemInform Abstract: Iron‐Catalyzed Cross‐Coupling Reaction: Recyclable Heterogeneous Iron Catalyst for Selective Olefination of Aryl Iodides in Poly(ethylene glycol) Medium.
Authors: Hajipour Abdol Reza , Azizi Ghobad 
Published: July 2013

AbstractAn iron‐based catalyst supported on acac‐functionalized silica is prepared and evaluated as a heterogeneous catalyst for Mizoroki‐Heck reactions of aryl iodides with olefins.
ChemInform Abstract: Efficient One‐Pot Synthesis of Propargylamines from Mannich Bases Through a Retro‐Mannich‐Type Fragmentation.
Authors: Zhu Yefeng , Zhao Huishuang , Wei Yunyang 
Published: July 2013

AbstractA novel method for the synthesis of propargylamines is developed by Cu‐catalyzed coupling of Tbp‐type Mannich bases with terminal alkynes and NCS (or NBS) as the oxidant.
ChemInform Abstract: Lewis Acid Catalyzed Formal Intramolecular [3 + 2] Cross‐Cycloaddition of Cyclopropane 1,1‐Diesters with Alkenes: General and Efficient Strategy for Construction of Bridged [n.2.1] Carbocyclic Skeletons.
Authors: Zhu Wenju , Fang Jie , Liu Yong , Ren Jun , Wang Zhongwen 
Published: July 2013

AbstractThe title reaction is successfully developed, and applied to the total synthesis of the tetracyclic diterpenoids phyllocladanol (XX) and phyllocladene (XXI).
ChemInform Abstract: Catalytic Enantioselective Vinylogous Mukaiyama—Michael Addition of 2‐Silyloxyfurans to Cyclic Unsaturated Oxo Esters.
Authors: Jusseau Xavier , Retailleau Pascal , Chabaud Laurent , Guillou Catherine 
Published: July 2013

AbstractThe products are obtained as a mixture of keto‐ and enol‐form.
ChemInform Abstract: Direct Lactonization of 2‐Arylacetic Acids Through Pd(II)‐Catalyzed C—H Activation/C—O Formation.
Authors: Yang Mingyu , Jiang Xingyu , Shi Wen‐Juan , Zhu Qi‐Lei , Shi Zhang‐Jie 
Published: July 2013

AbstractThe title reaction provides a direct and efficient method for the synthesis of fully functionalized benzofuranones from easily available β‐aryl substituted carboxylic acids.
ChemInform Abstract: One‐Pot Synthesis of 2H‐Phenanthro[9,10‐c]pyrazoles from Isoflavones by Two Dehydration Processes.
Authors: Wang Qiuya , Zhang Zunting , Du Zichao , Hua Huiliang , Chen Shasha 
Published: July 2013

AbstractThe title compounds are synthesized via cyclocondensation of isoflavones and hydrazine hydrate to obtain 3,4‐diaryl‐pyrazole intermediates.
ChemInform Abstract: Palladium‐Catalyzed Coupling of Polyfluorinated Arenes with Heteroarenes via C—F/C—H Activation.
Authors: Yu Daohong , Lu Long , Shen Qilong 
Published: July 2013

AbstractThe first Pd‐catalyzed coupling of 2‐pyridyl‐polyfluoroarenes and various heteroazoles is presented.
ChemInform Abstract: Ecofriendly Solventless Synthesis and Reduction Reaction of Some Triazole Compounds and Evaluation of Their Antimicrobial Activity.
Authors: Oezil Musa , Mentese Emre , Karaoglu Senguel Alpay , Kahveci Bahittin 
Published: July 2013

AbstractA series of triazole derivatives of type (III) and (IV) are prepared.
ChemInform Abstract: Domino Hydroarylation—Cyclization Reaction: One‐Pot Synthesis of Indane‐Fused 3,4‐Dihydrocoumarins.
Authors: Joo Jin Hyuck , Youn So Won 
Published: July 2013

AbstractThe title transformation is promoted by Sn(OTf)2, which acts as bi‐functional Lewis acidic catalyst.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Aromatic Ketones and Isoindolobenzimidazoles via Selective Aromatic C—H Bond Acylation.
Authors: Lu Juyou , Zhang Hao , Chen Xiaowu , Liu Hongxia , Jiang Yuyang , Fu Hua 
Published: July 2013

AbstractAn efficient synthesis of aromatic ketones (III) and isoindolobenzimidazoles (IX) via selective aromatic C—H activation is described.
ChemInform Abstract: Cobalt‐Catalyzed C4‐Selective Direct Alkylation of Pyridines.
Authors: Andou Takashi , Saga Yutaka , Komai Hirotomo , Matsunaga Shigeki , Kanai Motomu 
Published: July 2013

AbstractA novel catalyst system is developed for the direct alkylation of pyridines with monosubstituted olefins.
ChemInform Abstract: Favorskii‐Like Rearrangement of an Aliphatic α‐Halo Amide.
Authors: Kelly Nicholas M. , Wellejus Anja , Elbroend‐Bek Heidi , Weidner Morten Sloth , Joergensen Signe Humle 
Published: July 2013

AbstractThe reaction of α‐bromoamide (I) with cyclopentylpiperazine (II) gives the Favorskii‐like rearranged product (III) by treatment with aqueous potassium hydroxide.
ChemInform Abstract: Exceptionally E‐ and β‐Selective NHC—Cu‐Catalyzed Proto‐Silyl Additions to Terminal Alkynes and Site‐ and Enantioselective Proto‐Boryl Additions to the Resulting Vinylsilanes: Synthesis of Enantiomerically Enriched Vicinal and Geminal Borosilanes.
Authors: Meng Fanke , Jang Hwanjong , Hoveyda Amir H. 
Published: July 2013

AbstractProtosilylation of aliphatic and aromatic terminal alkynes proceeds with complete (E)‐β‐selectivity.
ChemInform Abstract: Enantio‐ and Diastereoselective Vinylogous Mukaiyama Aldol Reactions of α‐Keto Phosphonates with 2‐(Trimethylsilyloxy)furan Catalyzed by Bis(oxazoline)‐Copper Complexes.
Authors: Hou Gang , Yu Jipan , Yu Chengbin , Wu Guiping , Miao Zhiwei 
Published: July 2013

AbstractThe present method is suitable for functionalized α‐keto phosphonates (II) and allows the synthesis of α‐hydroxy phosphonates (III) bearing two chiral centers in high yields as well as high enantioselectivities.
Homomorphic authentication codes for network coding
Authors: Tang Zhaohui 
Published: July 2013

SummaryAuthentication codes (A‐codes) are a well studied technique to provide unconditionally secure authentication. An A‐code is defined by a map that associates a pair formed by a message and a key to a tag. A‐codes linear in the keys have been studied for application to distributed authentication schemes. In this paper, we address the dual question, which is the study of A‐codes that are linear in the messages. This is usually an undesired property, except in the context of network coding. Regarding these A‐codes, we derive some lower bounds on security parameters when key space is known. We also show a lower bound on key size when security parameter values are given (with some special properties) and construct some codes meeting the bound. We finally present a variant of these codes that authenticate multiple messages with the same key while preserving unconditional security. Copyright © 2013 John Wiley & Sons, Ltd.
Sustainability or Profitability? How Communicated Motives for Environmental Policy Affect Public Perceptions of Corporate Greenwashing
Authors: de Vries Gerdien , Terwel Bart W. , Ellemers Naomi , Daamen Dancker D. L. 
Published: July 2013

ABSTRACTCompanies in the energy sector face a dilemma regarding how to communicate their environmental policies to the public. Communicating that environmental policies and activities are motivated by concern for the environment could elicit positive reactions, but may also lead to accusations of corporate greenwashing – the idea that companies deliberately frame their activities as ‘green’ in order to look environmentally friendly. The results of three experiments demonstrate that people easily suspect greenwashing when an energy company invests in environmental measures. Importantly, suspicions of corporate greenwashing are reduced by acknowledging economic motives instead of communicating environmental motives for such investments. Suspicion of strategic organizational behavior mediates the effect of communicated motive on perceived corporate greenwashing. This indirect effect occurs primarily among people who are not by nature very skeptical about organizational communications in general. These findings highlight the need to think carefully about how to communicate corporate environmental policies to the public. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment