bluuebunny/crossref_metadata_2025_split huggingface dataset:
Headbutting through time: A review of this hypothesized behavior in “dome‐headed” fossil taxa
Authors: Woodruff D. Cary , Ackermans Nicole L. 
Published: July 2024

AbstractHeadbutting is a combative behavior most popularly portrayed and exemplified in the extant bighorn sheep (Ovis canadensis). When behaviorally proposed in extinct taxa, these organisms are oft depicted Ovis‐like as having used modified cranial structures to combatively slam into one another. The combative behavioral hypothesis of headbutting has a long and rich history in the vertebrate fossil literature (not just within Dinosauria), but the core of this behavioral hypothesis in fossil terrestrial vertebrates is associated with an enlarged osseous cranial dome—an osteological structure with essentially no current counterpart. One confounding issue found in the literature is that while the term “headbutting” sounds simplistic enough, little terminology has been used to describe this hypothesized behavior. And pertinent to this special issue, potential brain trauma and the merits of such proposed pugilism have been assessed largely from the potential deformation of the overlying osseous structure; despite the fact that extant taxa readily show that brain damage can and does occur without osteological compromise. Additionally, the extant taxa serving as the behavioral counterpart for comparison are critical, not only because of the combative behaviors and morphologies they display, but also the way they engage in such behavior. Sheep (Ovis), warthogs (Phacochoerus), and bison (Bison) all engage in various forms of “headbutting”, but the cranial morphologies and the way each engages in combat is markedly different. To hypothesize that an extinct organism engaged in headbutting like an extant counterpart in theory implies specific striking:contacting surfaces, speed, velocity, and overall how that action was executed. This review examines the history and usage of the headbutting behavioral hypothesis in these dome‐headed fossil taxa, their respective extant behavioral counterparts, and proposes a protocol for specific behavioral terms relating to headbutting to stem future confusion. We also discuss the disparate morphology of combative cranial structures in the fossil record, and the implications of headbutting‐induced brain injury in extinct taxa. Finally, we conclude with some potential implications for artistic reconstructions of fossil taxa regarding this behavioral repertoire.
ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing‐Associated Lymphangiogenesis
Authors: Yamashita Takashi , Kaplan Ulas , Chakraborty Adri , Marden Grace , Gritli Sami , Roh Daniel , Bujor Andreea , Trojanowski Marcin , Ligresti Giovanni , Browning Jeffrey L. , Trojanowska Maria 
Published: July 2024

ObjectiveRarefaction of blood and lymphatic vessels in the skin has been reported in systemic sclerosis (SSc) (scleroderma). E26 transformation–specific–related factor (ERG) and Friend leukemia virus–induced erythroleukemia 1 (FLI‐1) are important regulators of angiogenesis, but their role in lymphatic vasculature is lesser known. The goal of this study was to determine the role of ERG and FLI‐1 in postnatal lymphangiogenesis and SSc lymphatic system defects.MethodsImmunofluorescence was used to detect ERG and FLI‐1 in skin biopsy samples from patients with SSc and healthy controls. Transcriptional analysis of ERG or FLI‐1–silenced human dermal lymphatic endothelial cells (LECs) was performed using microarrays. Effects of ERG and FLI‐1 deficiency on in vitro tubulogenesis in human dermal LECs were examined using a Matrigel assay. ERG and FLI‐1 endothelial–specific knockouts and ERG lymphatic–specific knockouts were generated to examine vessel regeneration in mice.ResultsERG and FLI‐1 protein levels were reduced in the blood and lymphatic vasculature in SSc skin biopsy samples. ERG levels were shown to regulate genes involved in lymphatic vessel specification, including vascular endothelial growth factor receptor 3/FLT‐4, lymphatic vessel endothelial hyaluronan receptor 1, SOX‐18, and prospero homeobox 1 (PROX‐1), whereas FLI‐1 enhanced the function of ERG. The ERG–FLT‐4 pathway regulated in vitro tubulogenesis in human LECs. Deficiency of ERG or FLI‐1 similarly impaired the function of blood vessels in mice. However, only ERG deficiency affected the regeneration of lymphatic vessels during wound healing.ConclusionERG and FLI‐1 are essential regulators of blood and lymphatic vessel regeneration. Deficiency of ERG and FLI‐1 in SSc endothelial cells may contribute to the impairment of blood and lymphatic vasculature in patients with SSc.image
Emotional preparedness for human body donor dissection in premedical education: A pilot program evaluation
Authors: Manyama Mange , Carey Matthew A. , Sarada Padmakumari , Bendriss Rachid 
Published: July 2024

AbstractDissection of bodies provided by donors continues to be utilized as a critical part of medical education. It also represents a rite of passage that socializes students to prepare them for the stress that comes with working in a clinical environment as a medical professional. Just as proper guidance in acquiring technical skills is critical in anatomy education, there is an important need for proper emotional guidance throughout the human dissection process. A pilot curriculum was developed by an interdisciplinary faculty team to emotionally prepare students for their first visit to the anatomy laboratory. Students were first‐year foundation premedical students who had expressed an interest in visiting the laboratory. Pre‐ and post‐visit surveys were conducted to explore students' emotional responses to a first visit to the anatomy laboratory and their utilization of coping strategies. The survey findings show an overwhelming favorable feeling in anticipation of the human gross anatomy laboratory visit. About 20% of the students experienced anxiety at the anticipation of the laboratory visit, but only 5.3% experienced anxiety during the visit. The decrease in the number of students experiencing anxiety may be attributed to the interventions introduced before and during the visit. Talking with a close friend was the main coping strategy utilized by 63% of students experiencing fear or anxiety during and after the laboratory visit. The findings from this program evaluation provide a better understanding of student emotional preparedness and utilization of coping strategies, which may help prepare and guide future students for the dissection experience.
Purification of xylosaccharides from eucalyptus residues for l‐lactic acid production by Weizmannia coagulans
Authors: Cabrera María‐Noel , Vila Eugenia , Liguori Alberto , D’Andrada Constanza , Moure Santiago , Guigou Mairan , Cebreiros Florencia , Rodao Juan Martín , Camesasca Laura , Ferrari Mario Daniel , Lareo Claudia 
Published: July 2024

AbstractIn this work, phosphoric acid pretreatment (0.6% H3PO4, 160 °C, 40 min) of eucalyptus residues was performed to recover the hemicellulosic fraction for further conversion to l‐lactic acid by fermentation with Weizmannia coagulans DSM 2314 (formerly Bacillus coagulans). The hemicellulosic hydrolysate was composed of xylosaccharides 24.8 g L–1 (mainly xylose, 20.3 g L–1), acetic acid 7.8 g L–1, furfural 0.7 g L–1, and acid‐soluble lignin (ASL) 2.1 g L–1. It was subsequently purified by using anion exchange or adsorption resins. Different liquor‐to‐resin ratios were evaluated to obtain a high concentration of xylosaccharides in the eluate and thorough removal of components that inhibit lactic fermentation. The best performance was observed when using Amberlite‐XAD‐4 resin at a liquor‐to‐resin ratio of 3:1. An eluted hydrolysate was obtained, preserving 80% of the xylosaccharides and effectively removing almost all furfural, 90% of ASL, and 32% of acetic acid. Subsequently, l‐lactic acid production by W. coagulans DSM 2314 was evaluated using concentrated nondetoxified and detoxified hydrolysate obtained with a vacuum oven. For the nondetoxified hydrolysate, 12 g L–1 of l‐lactic acid was obtained after 48 h showing a yield of 0.56 glactic acid gsugar–1 and a xylose consumption of 62%. The detoxification of the liquor significantly improved the fermentation performance of W. coagulans, resulting in a concentration of 16 g L–1 of lactic acid after 24 h, with a yield of 0.73 glactic acid gsugar–1, and almost complete xylose consumption.
Ein Supermarkt aus Infraleichtbeton
Authors: Reyher Boris , Stelzner Ludwig , Hothan Sascha , Hückler Alex , Pistol Klaus , Madlener Simon , Schlaich Mike 
Published: July 2024

AbstractInfraleichtbeton (ILC) ist eine spezielle Form von Leichtbeton, der durch seine niedrige Rohdichte im Vergleich zu herkömmlichem Beton eine verbesserte Wärmedämmeigenschaft aufweist. Infraleichtbeton ermöglicht die monolithische einschichtige Konstruktion von Bauteilen der Gebäudehülle ohne additive Wärmedämmung und Fassadenbekleidung. Dadurch wird die Baukonstruktion gegenüber herkömmlich gedämmten Betonbauteilen erheblich vereinfacht und die Recyclingfähigkeit deutlich verbessert. Zudem weisen Bauteile aus Infraleichtbeton eine günstigere CO2‐Bilanz auf als Außenwandkonstruktionen in konventioneller Bauweise wie z. B. Wärmedämmverbundsysteme. Nach etwa 15 Jahren Forschung und diversen Bauvorhaben im Wohn‐ und Bildungssektor konnte nun ein erster Einzelhandelsmarkt mit Außenwänden aus Infraleichtbeton realisiert werden. Im Rahmen dieses Bauvorhabens wurde erfolgreich eine vorhabenbezogene Bauartgenehmigung (vBG) auf der Grundlage eines Brandversuchs und eines auf Berechnungen basierenden Übertragungskonzepts für eine Brandwand aus ILC erwirkt. Der Beitrag stellt das Übertragungskonzept sowie ein für die vorliegende besondere Bauweise der Brandwand entwickeltes vereinfachtes Berechnungsverfahren zum Nachweis der Standsicherheit im Brandfall vor.
Functional Multivariable Logistic Regression With an Application to HIV Viral Suppression Prediction
Authors: Guo Siyuan , Zhang Jiajia , Wu Yichao , McLain Alexander C. , Hardin James W. , Olatosi Bankole , Li Xiaoming 
Published: July 2024

ABSTRACTMotivated by improving the prediction of the human immunodeficiency virus (HIV) suppression status using electronic health records (EHR) data, we propose a functional multivariable logistic regression model, which accounts for the longitudinal binary process and continuous process simultaneously. Specifically, the longitudinal measurements for either binary or continuous variables are modeled by functional principal components analysis, and their corresponding functional principal component scores are used to build a logistic regression model for prediction. The longitudinal binary data are linked to underlying Gaussian processes. The estimation is done using penalized spline for the longitudinal continuous and binary data. Group‐lasso is used to select longitudinal processes, and the multivariate functional principal components analysis is proposed to revise functional principal component scores with the correlation. The method is evaluated via comprehensive simulation studies and then applied to predict viral suppression using EHR data for people living with HIV in South Carolina.
Development of fluorescence probe for spectrofluorimetric determination of viloxazine hydrochloride in pharmaceutical form and rat plasma; additional pharmacokinetic study
Authors: Almalki Atiah H. , Alnemari Reem M. , Abduljabbar Maram H. , Abdelazim Ahmed H. 
Published: July 2024

AbstractAttention deficit hyperactivity disorder (ADHD) is a neurological condition frequently identified in early childhood and frequently co‐occurs with other neuropsychological disorders, particularly autism. Viloxazine hydrochloride, a non‐stimulant medication, has recently gained approval for treating attention‐deficit hyperactivity disorder. This paper describes the first spectrofluorimetric method for precisely measuring the content of viloxazine in pharmaceutical capsules and rat plasma. This method employed NBD‐Cl (4‐chloro‐7‐nitrobenzo‐2‐oxa‐1,3‐diazole) as a fluorescent probe, which transformed viloxazine in an alkaline environment into a remarkably sensitive fluorescent adduct. Upon excitation at 476 nm, this adduct becomes detectable at a wavelength of 536 nm. The method was validated using ICH criteria, revealing acceptable linearity across a concentration range of 200–2000 ng/ml and high sensitivity with LOD and LOQ values of 46.774 ng/ml and 141.741 ng/ml, respectively. This method was adeptly applied in a pharmacokinetic study of viloxazine in rat plasma following a single oral dose (10 mg/kg), yielding a mean peak plasma concentration (Cmax) of 1721 ng/ml, achieved within 1.5 h. Furthermore, the environmental impact of the technique was assessed using two greenness assessment tools, revealing a notable level of eco‐friendliness and sustainability.
Eco‐centric success: Stakeholder approaches to sustainable performance via green improvisation behavior and environmental orientation in the hotel industry
Authors: Murtaza Syed Hussain , Khan Adnan , Mustafa Syed Muhammad 
Published: July 2024

AbstractThis study delves into the relationship between green improvisational behavior (GIB), environmental orientation (EO), a green creative climate (GCC), and how they influence the environmental (EP) and social performance (SP) in the hotel industry. Through the perspective of stakeholder theory, the study examines how these factors work together to cultivate an atmosphere. The data was carefully collected through surveys at Pearl Continental Hotels & Resorts branches, a known chain of luxury hotels in Pakistan. Using Structural Equation Modeling for analysis, the study reveals insights for the hospitality industry in promoting a culture that encourages innovative and sustainable practices through environmentally friendly actions. By understanding what drives the development of an environment, hotels can create an organizational culture that supports eco‐friendly initiatives. Additionally, this research contributes to existing knowledge by investigating the role of focus in effectively implementing and utilizing practices that promote a green creative climate for improved environmental and social performance within the hotel industry. The results provide implications for practices within hotels and offer theoretical perspectives on the factors driving sustainability efforts in this sector.
Suicide on Italian Instagram: Insights and implications for prevention and support
Authors: Olcese Martina , Antichi Lorenzo , Madera Francesco , Cardinali Paola , Prestia Davide , Serafini Gianluca , Dettore Davide , Casale Silvia , Giannini Marco , Martinotti Giovanni , Migliorini Laura 
Published: July 2024

AbstractInstagram is the social network with the largest number of adolescent users in Italy; it is also the social network with the largest number of suicide‐related posts. Suicide is the third leading cause of death in Italy in the 15–19 age group. This study aims to describe Italian posts on Instagram related to suicide and to investigate whether there are differences in the number of likes, comments, and hashtags in relation to the characteristics of the posts. We searched for Italian‐language Instagram posts by typing ‘#suicidio’, an Italian translation of the English word ‘suicide’, and found 303 posts between January and May 2022. Most of the posts were written by ordinary people, while only a small percentage of posts were written by professionals; moreover, the content was predominantly biographical and pro‐suicide, and most posts had no reference to adolescence. Posts with a neutral approach received the most likes, while posts with a negative or positive approach to suicide or that contained references to psychiatric disorders had the most hashtags. These results provide insight regarding guidelines that can be implemented for suicide online prevention and encourage psychologists to enhance online prevention and support using the online community inherent to the Instagram social network.
A Comparative Study of Impact Fracture Toughness of Epoxidized Poly(1, 4 Cis‐Isoprene) Compatibilized PLA Binary and Ternary Blends
Authors: Bijarimi Mohd , Ahmad Sahrim , Ode La , Mustaqeem Mujahid , Norazmi M. , Normaya Erna , Jaafar Jamiluddin 
Published: July 2024

AbstractPoly(lactic acid) (PLA) is a biodegradable polymer with limited application because of its intrinsic brittleness, low toughness, and low elongation at break. Melt blends were prepared by mixing a natural rubber (NR, poly(1,4‐cis‐isoprene) in the form of liquid NR (LNR), liquid‐epoxidized NR (LENR), and polypropylene (PP) in the PLA matrix. Four blend systems were designed and prepared, i.e., PLA–PP, PLA–PP–LNR, and PLA–LNR or PLA–LENR. The composition of PP in the blend was fixed at 10 % PLAPP (90/10). Results showed that PLA–PP mixed with LNR improved impact and elongation at break. The binary blend of PLA–LNR (90/10) significantly enhanced impact strength and elongation at break properties. In contrast, the binary blends of PLA–LENR (90/10) showed a lower value of elongation at break (9.5 % vs. 37.3%) and impact strength (4.56 kJ m−2 vs. 6.44 kJ m−2). The melting temperature (Tm) and the glass transition temperature (Tg) were measured by differential scanning calorimetry, which recorded slight changes in the glass temperatures and melting temperatures. Scanning electron microscopy images of the tensile fracture of the PLA–LNR (90/10) blend showed the presence of large fibrils associated with the ductile failure related to neat PLA. Finally, the fracture toughness (KIC) of PLA–LNR (90/10) showed an increase of 39 % over neat PLA (2.94 MPa.m1/2 vs. 4.08 MPa.m1/2).
Identification of intrinsic vacancies and polarization effect on ternary halo‐sulfur‐bismuth compounds for efficient CO2 photoreduction under near‐infrared light irradiation
Authors: Li Jun , Chai Qingqing , Niu Ranran , Pan Wenfeng , Chen Zhiquan , Wang Liang , Wang Kai , Liu Zhongyi , Liu Yifeng , Xiao Yao , Liu Bin 
Published: July 2024

AbstractTernary halo‐sulfur bismuth compound Bi19X3S27 (X = Cl, Br, I) with distinct electronic structure and full‐spectrum light‐harvesting properties show great application potential in the CO2 photoreduction field. However, the relationship between photocatalytic CO2 reduction performance and the function of halogens in Bi19X3S27 is still poorly understood. Herein, a series of Bi19X3S27 nanorod photocatalysts with intrinsic X and S dual vacancies were developed, which showed significant near‐infrared (NIR) light responses. The types and concentrations of intrinsic vacancies were confirmed and quantified by positron annihilation spectrometry and electron spin resonance spectroscopy. Experimental results showed that Br atoms and intrinsic vacancies (dual Br‐S) in Bi19Br3S27 could greatly enhance the internal polarized electric field and improve the transfer and separation of photogenerated carriers compared with Bi19Cl3S27 and Bi19I3S27. Theoretical calculations revealed that Br atoms in Bi19Br3S27 could facilitate CO2 adsorption and activation and decrease the formation energy of reactive hydrogen. Among Bi19X3S27 nanorods, Bi19Br3S27 nanorods revealed the highest CO2 photoreduction activity with CO yield rate of 28.68 and 2.28 μmol gcatalyst−1 h−1 with full‐spectrum and NIR lights, respectively. This work presents an atomic understanding of the intrinsic vacancies and halogen‐mediated CO2 photoreduction mechanism.
Enhanced water‐splitting performance: Interface‐engineered tri‐metal phosphides with carbon dots modification
Authors: Jiang Yingnan , Yu Jingkun , Song Haoqiang , Du Lingling , Sun Wenxuan , Cui Yulong , Su Yuwen , Sun Meiling , Yin Guangchao , Lu Siyu 
Published: July 2024

AbstractDesigning integrated overall water‐splitting catalysts that maintain high efficiency and stability under various conditions is an important trend for future development, yet it remains a significant challenge. Herein, novel nanoflower‐like tri‐metallic Ni–Ru–Mo phosphide catalyst ((Ni–Ru–Mo)P@F‐CDs), integrated with F‐doped carbon dots (F‐CDs), were synthesized via a straightforward hydrothermal process and subsequent phosphatization. Attributable to precise interface engineering and electronic structure optimization, (Ni–Ru–Mo)P@F‐CDs exhibit exceptional bi‐functional catalytic activity in alkaline conditions, achieving remarkably low overpotentials of 231 and 123 mV for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), respectively, at a current density of 100 mA cm−2. Industrially, only 1.426 V is needed for the same efficacy. Additionally, the catalyst requires merely 1.508 and 1.564 V for overall water splitting in 1 M KOH and simulated seawater, respectively, at 100 mA cm−2. The catalyst also shows excellent stability, with minimal performance decline over 100 h within 100–200 mA cm−2. Density functional theory calculations indicate that the interface structure synergistically optimizes Gibbs free energy for H* and O* intermediates during HER and OER, respectively, accelerating electrochemical water‐splitting kinetics.
Stimuli‐Induced Fluorescence Switching in Azine‐Containing Fluorophores Displaying Resonance‐Stabilized ESIPT Emission
Authors: Stoerkler Timothée , Ulrich Gilles , Retailleau Pascal , Achelle Sylvain , Laurent Adèle D. , Jacquemin Denis , Massue Julien 
Published: July 2024

AbstractThis article reports the synthesis, along with structural and photophysical characterization of 2‐(2’‐hydroxyphenyl)benzazole derivatives functionalized with various azaheterocycles (pyridine, pyrimidine, terpyridine). These compounds show dual‐state emission properties, that is intense fluorescence both in solution and in the solid‐state with a range of fluorescent color going from blue to orange. Moreover, the nature of their excited state can be tuned by the presence of external stimuli such as protons or metal cations. In the absence of stimuli, these dyes show emission stemming from anionic species obtained after deprotonation (D* transition), whereas upon protonation or metal chelation, ESIPT process occurs leading to a stabilized and highly emissive K* transition. With the help of extensive ab initio calculations, we confirm that external stimuli can switch the nature of the transitions, making this series of dyes attractive candidates for the development of stimuli‐responsive fluorescent ratiometric probes.
Induced Chirality in Sulfasalazine by Complexation With Albumins: Theoretical and Experimental Study
Authors: Grandini Giulia Saneti , Ximenes Valdecir Farias , Morgon Nelson Henrique , de Souza Aguinaldo Robinson 
Published: July 2024

AbstractThrough molecular recognition, drugs can interact and complex with macromolecules circulating in the body. The serum albumin transport protein, found in several mammals, has several interaction sites where these molecules can be located. The drug sulfasalazine (SSZ) is known in the literature to complex at drug site 1 (DS1) in human serum (HSA) and bovine serum (BSA) proteins. This complexation can be studied using various spectroscopic techniques. With the techniques used in this work, absorption in the ultraviolet and visible regions (UV–Vis) and electronic circular dichroism (ECD), a significant difference was observed in the results involving HSA and BSA. The application of theoretical methodologies, such as TD‐DFT and molecular docking, suggests that the conformation that SSZ assumes in DS1 of the two proteins is different, which exposes it to different amino acid residues and different hydrophobicities. This difference in conformation may be related to the location of DS1 where the drug interacts or to the possibility of SSZ moving in the BSA site, due to its larger size, and moving less freely in HSA.