bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eight-Fold Increased COVID-19 Mortality in Autosomal Dominant Tubulointerstitial Kidney Disease due toMUC1Mutations: An Observational Study
Authors: Kidd Kendrah O. , Williams Adrienne H. , Taylor Abbigail , Martin Lauren , Robins Victoria , Sayer John A. , Olinger Eric , Mabillard Holly R. , Papagregoriou Gregory , Deltas Constantinos , Stavrou Christoforos , Conlon Peter J. , Hogan Richard Edmund , Elhassan Elhussein A.E. , Springer Drahomíra , Zima Tomáš , Izzi Claudia , Vrbacká Alena , Piherová Lenka , Pohludka Michal , Radina Martin , Vylet’al Petr , Hodanova Katerina , Zivna Martina , Kmoch Stanislav , Bleyer Anthony J. 
Published: July 2024

ABSTRACTBackgroundMUC1andUMODpathogenic variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD).MUC1is expressed in kidney, nasal mucosa and respiratory tract, whileUMODis expressed only in kidney. Due to haplo-insufficiency ADTKD-MUC1patients produce approximately 50% of normal mucin-1.MethodsTo determine whether decreased mucin-1 production was associated with an increased COVID-19 risk, we sent a survey to members of an ADTKD registry in September 2021, after the initial, severe wave of COVID-19. We linked results to previously obtained ADTKD genotype and plasma CA15-3 (mucin-1) levels and created a longitudinal registry of COVID-19 related deaths.ResultsSurveys were emailed to 637 individuals, with responses from 89 ADTKD-MUC1and 132 ADTKD-UMODindividuals. 19/83 (23%) ADTKD-MUC1survey respondents reported a prior COVID-19 infection vs. 14/125 (11%) ADTKD-UMODrespondents (odds ratio (OR) 2.35 (95%CI 1.60-3.11,P= 0.0260). Including additional familial cases reported from survey respondents, 10/41 (24%) ADTKD-MUC1individuals died of COVID-19 vs. 1/30 (3%) with ADTKD-UMOD, with OR 9.21 (95%CI 1.22-69.32),P= 0.03. The mean plasma mucin-1 level prior to infection in 14 infected and 27 uninfected ADTKD-MUC1individuals was 7.06±4.12 vs. 10.21±4.02 U/mL (P= 0.035). Over three years duration, our longitudinal registry identified 19 COVID-19 deaths in 360 ADTKD-MUC1individuals (5%) vs. 3 deaths in 478 ADTKD-UMODindividuals (0.6%) (P= 0.0007). Multivariate logistic regression revealed the following odds ratios (95% confidence interval) for COVID-19 deaths: ADTKD-MUC18.4 (2.9-29.5), kidney transplant 5.5 (1.6-9.1), body mass index (kg/m2) 1.1 (1.0-1.2), age (y) 1.04 (1.0-1.1).ConclusionsIndividuals with ADTKD-MUC1are at an eight-fold increased risk of COVID-19 mortality vs. ADTKD-UMODindividuals. Haplo-insufficient production of mucin-1 may be responsible.
Effect of truffle extracts on growth ofChlorella vulgaris
Authors: Vlasova Anfisa A. , Lipatova Olga E. , Belyshenko Alexander Y. , Martynova Elena I. , Imidoeva Natalia A. , Telnova Tamara Y. , Malygina Ekaterina V. , Morgunova Maria M. , Dmitrieva Maria E. , Shelkovnikova Victoria N. , Shashkina Sophia S. , Vavilina Tatiana N. , Axenov-Gribanov Denis V. 
Published: July 2024

ABSTRACTTruffles are hypogeous ectomycorrhizal fungi with a complex system of chemical communications and biotic interactions. This study examines the influence of truffle extracts on the growth of the algaChlorella vulgarisas a model organism commonly employed in pharmacology, food industry and biomonitoring. The study involved sampling of fruiting bodies of black truffles in a number of regions across Russia, over a number of years. The observed differences in truffle condition were used to illustrate a potential correlation between the quality and biological activity of truffles. Methanolic extracts were prepared and added to the culture ofC. vulgaristo evaluate the growth of algae using the spectrophotometry methods. For the first time, we demonstrated that truffle extracts had biological activity in terms of the algaeC. vulgarisgrowth stimulation. We observed the effects of short-term and long-term growth stimulation. To date, it can be concluded that there is no direct correlation between the stimulating effects on algae and the state of truffles, place of their sampling, or their quality. Finally, it is crucial to examine biological regulations that operate in complex systems such as truffles. It is suggested that in the near future truffles may become a model system for the study of complex biotic and chemical communications.
Transcriptome-wide characterization of genetic perturbations
Authors: Nadig Ajay , Replogle Joseph M. , Pogson Angela N. , McCarroll Steven A , Weissman Jonathan S. , Robinson Elise B. , O’Connor Luke J. 
Published: July 2024

AbstractSingle cell CRISPR screens such as Perturb-seq enable transcriptomic profiling of genetic perturbations at scale. However, the data produced by these screens are often noisy due to cost and technical constraints, limiting power to detect true effects with conventional differential expression analyses. Here, we introduce TRanscriptome-wide Analysis of Differential Expression (TRADE), a statistical framework which estimates the transcriptome-wide distribution of true differential expression effects from noisy gene-level measurements. Within TRADE, we derive multiple novel, interpretable statistical metrics, including the “transcriptome-wide impact”, an estimator of the overall transcriptional effect of a perturbation which is stable across sampling depths. We analyze new and published large-scale Perturb-seq datasets to show that many true transcriptional effects are not statistically significant, but detectable in aggregate with TRADE. In a genome-scale Perturb-seq screen, we find that a typical gene perturbation affects an estimated 45 genes, whereas a typical essential gene perturbation affects over 500 genes. An advantage of our approach is its ability to compare the transcriptomic effects of genetic perturbations across contexts and dosages despite differences in power. We use this ability to identify perturbations with cell-type dependent effects and to find examples of perturbations where transcriptional responses are not only larger in magnitude, but also qualitatively different, as a function of dosage. Lastly, we expand our analysis to case/control comparison of gene expression for neuropsychiatric conditions, finding that transcriptomic effect correlations are greater than genetic correlations for these diagnoses. TRADE lays an analytic foundation for the systematic comparison of genetic perturbation atlases, as well as differential expression experiments more broadly.
Comparative Genomic Analysis of Metal-Tolerant Bacteria Reveals Significant Differences in Metal Adaptation Strategies
Authors: Chen Dai Di , Zhang Liu Lian , Zhang Jiu Hua , Ban Wen Ting , Li Qingxin , Wu Jin Chuan 
Published: July 2024

ABSTRACTMetal-tolerant bacteria have been commercially used in wastewater treatment, bio-fertilizer and soil remediation etc. However, their action mechanisms have not yet been well understood. We screened metal-tolerant bacteria isolated from the rhizosphere soil samples with metal-enriched media containing Cu, Fe or Mn, sequenced and compared the genomes, and analyzed their metal adaptation strategies at genomic levels to better understand their mechanisms of actions. Totally 32 metal-tolerant isolates were identified and classified into 12 genera based on phylogenetic analysis. The determination of MTC and effect of metal ions on the isolates indicated thatSerratia marcescensX1,Mammaliicoccus sciuriX26 andRummeliibacillus pycnusX33 showed the significant differences in metal tolerance to Cu, Fe and Mn with other isolates. They have quite different genomic features to adapt various metal ions.S. marcescensX1 possesses abundant genes required for Cu, Fe and Mn homeostasis.M. sciuriX26 has a number of genes involved in Mn and Zn homeostasis but with no genes responsible for Cu and Ca transport.R. pycnusX33 is rich in Fe, Zn and Mg transport systems but poor in Cu and Mn transport systems. It is thus inferred that the combined use of them would compensate their differences and enhance their ability in accumulating a wider range of heavy metals for promoting their applications in wastewater treatment, soil remediation and organic fertilizer etc.IMPORTANCEMetal-tolerant bacteria have wide applications in environment, agriculture and ecology, but their action strategies have not yet been well understood. We isolated 32 metal-tolerant bacteria from the rhizosphere soil samples. Among them,S. marcescensX1,M. sciuriX26 andR. pycnusX33 showed the significant differences in metal tolerance to Cu, Fe and Mn with other isolates. Comparative genomic analysis revealed that they have abundant and different genomic features to adapt various metal ions. It is thus inferred that the combined use of them would compensate their differences and enhance their ability in accumulating heavy metal ions widening their applications in industry, agriculture and ecology.
Exploring factors influencing aviation MRO services with blockchain technology in Taiwan
Authors: Lin Yenhsu , Chiu Rong-Her 
Published: July 2024

Purpose
Blockchain is the fastest-growing technology currently being used in the aviation industry, especially in aviation maintenance, repair and overhaul (MRO) services. This study aims to create an analytic framework to assess the main factors and subfactors that have significantly influence the blockchain used in aviation MRO services. A mixed-methods approach is used to gain a comprehensive understanding of how blockchain is being adopted in aircraft maintenance facilities, Semi-structured interviews and questionnaires are used to gather data. The questionnaire is focused on the present state of the MRO industry.

Design/methodology/approach
Based on the literature review, a framework including four factors and 12 subfactors is developed, and the analytic hierarchy process (AHP) is then established. This study explores how these factors influence the implementation of blockchain in aviation MRO services. The five aviation MRO services providers in Taiwan, namely, “Evergreen Aviation Technologies Corporation,” “Taiwan Aircraft Maintenance and Engineering Co., Ltd.,” “Air Asia Company Ltd.,” “Aerospace Industrial Development Corp.” and “GE Evergreen Engine Services Corporation” are considered; furthermore, 55 experts working in these organizations were invited to evaluate the relative importance criteria in the AHP framework.

Findings
The results indicate that “inventory management” is the most important criterion, followed by “provisioning, procurement and sales” and “maintenance planning.” In addition, the three most important subfactors are “parts interchangeability,” “customer stock” and “SPEC2K interface for ATA SPEC 2000.”

Originality/value
Asia is ranked as the second most important aviation MRO service market in the world. Taiwan has the shortest flight hours in the western Pacific region, the seven major foreign cities in this area. Aviation MRO service providers located in Taiwan are the best choices for aircraft MRO in the Asia-Pacific region, indicating that Taiwan serves as a promising market development evaluation model for blockchain aviation MRO services. The results offer a comprehensive overview of the relative importance of different criteria for MRO services that use blockchains. In addition, the findings present the market potential for key players in the aviation industry, including aircraft engineers, airline companies, aircraft component manufacturers and aviation MRO service providers.
Cognitive load assessment for cadet pilots in simulated aircraft environment-pilot study
Authors: Alharasees Omar , Kale Utku 
Published: July 2024

Purpose
This study aims to propose a methodology aimed at understanding the cognitive and physiological processes inherent in cadet pilot operations. Through analyzing responses from two cadet pilots with varied experience levels across diverse simulation scenarios, the research uses descriptive statistics, t-test, one-way ANOVA and percentage change analysis to explore crucial variables, including heart rate (HR), heart rate variability (HRV) and respiratory rate (RR).

Design/methodology/approach
The investigation meticulously examines HR, HRV and RR under circumstances encompassing resting state, visual flight rules and instrument flight rules with engine failure. Pilots undergo comprehensive analyses employing statistical techniques and visual representations to comprehend cognitive loads and physiological adaptations.

Findings
Significant disparities emerge between the two pilots, elucidating the profound impact of experience on cognitive and physiological outcomes. Novice cadet pilots exhibit heightened variability during scenario transitions, while experienced cadet pilot demonstrate controlled responses, indicative of adaptability. Visual flight simulations evoke distinct responses, whereas instrument-based scenarios, particularly those simulating emergencies, lead to pronounced physiological changes.

Practical implications
The findings of this research hold practical significance in introducing the proposed novel methodology for monitoring Cadet pilots to refine pilot training simulation protocols and enhance aviation safety by illuminating the interplay between experience levels and scenario complexities.

Originality/value
This study proposes a novel methodology for investigating cognitive and physiological responses in pilot operations, mainly investigating cadet pilots’ vital parameters through diverse analytical methods and an exploration of scenario-specific demands.
Revenue-sharing vs. cost-sharing contracts in motivating supplier corporate social responsibility
Authors: Li Furong , Lv Fei 
Published: July 2024

PurposeTo motivate the supplier to exert more corporate social responsibility (CSR) effort, the manufacturer offers it either a revenue sharing contract or a cost sharing contract. We study the contract choice of the manufacturer.Design/methodology/approachWe develop game theoretic models to investigate the manufacturer’s optimal contract choice and examine whether there is a conflict of contract preference between the manufacturer and the supplier.FindingsFirst, the revenue sharing contract has more strict conditions regarding the unit cost of the supplier’s CSR effort and the manufacturer’s retail price. Second, the cost sharing contract enables the manufacturer to achieve a “win-win” performance in terms of both profitability and CSR effort. Finally, the supplier prefers the cost sharing contract when the manufacturer’s price is low, otherwise, it prefers the revenue sharing contract.Originality/valueDiffering from the papers on CSR, our paper focuses on the supplier CSR management problem, and analyzes the optimal contract to motivate the supplier to exert more CSR effort.
Restaurant waiting staff's intention to dissuade customers from over-ordering: an extended theory of planned behaviour
Authors: Yang Chieh Yun , Yan Libo , Ji Pengfei 
Published: July 2024

PurposeThis study aims to validate the impact of waiting staff’s attitudes, subjective norms, and perceived behavioural control on customer dissuasion from over-ordering and identify their antecedents using an extended theory of planned behaviour.Design/methodology/approachWe selected three categories of restaurants (30 in total, including fine dining, casual dining, and fast food) in Macao and Zhuhai (China) for conducting the survey using a purposive sampling approach. The respondents were waiting staff who took customers’ orders in the past three months. In total, 393 valid responses were used for a structural-equation-modelling analysis.FindingsThe results show that restaurant waiting staff’s attitudes, subjective norms, and perceived behavioural control have positive effects on their intention to dissuade customers from over-ordering. Our study further reveals that perceived behavioural control is far more influential than attitudes and subjective norms on restaurant employees’ intentions to intervene with over-ordering. We also validate seven antecedents, including environmental concern and communication for attitudes, peer influence, supervisor influence, and organisational support for subjective norms, and self-efficacy and training for perceived behavioural control.Originality/valueThe food-waste literature tends to focus on consumers in home and restaurant settings and has paid scarce attention to the role of restaurant waiting staff in intervening in consumers’ waste behaviours. We fill in this research gap by revealing a formation mechanism for waiting staff’s intention to dissuade over-ordering.
Feasibility of adopting imperfect produce in on-site foodservice: expert opinions and consumer sensory discrimination
Authors: Jarvis Nathan , Legendre Tiffany S. , Lee Rachel Hyunkyung 
Published: July 2024

PurposeThis research aims to investigate the feasibility of imperfect produce use in the on-site foodservice management industry.Design/methodology/approachStudy 1 explored experts’ perspectives via expert interviews on the use of imperfect produce in on-site foodservice operations, acceptability, and willingness to choose imperfect produce. Study 2, a sensory discrimination test, was performed with 100 consumers.FindingsStudy 1 yielded seven themes with managerial recommendations: appearance perception, customer value perception, operational difficulties, concerns for the world, food safety concerns, corporate advantages, and implementation. Study 2 found that participants were willing to choose menu items prepared with imperfect produce over those prepared with perfect produce. The ability to taste differences depended on the type of produce; participants could not taste differences between tangerines but could taste differences between apples and pears.Research limitations/implicationsThe findings of this study suggested that the psychological barriers of imperfect produce impact managers’ perceptions and decision-making processes. It is recommended that operators communicate with consumers about imperfect produce, its waste reduction benefits, and its quality.Originality/valueThis study shows that taste perception could be influenced by how imperfectness is described. Thus, appropriate marketing strategies could improve consumer acceptance of imperfect produce.
CEO individualism and corporate innovation
Authors: Zhang Fan 
Published: July 2024

PurposeThis paper aims to study the impact of CEOs' cultural background on corporate innovation. The paper constructs a measure of CEOs' cultural individualism based on their birthplaces and investigates its relationship with firms' patents and citations. The study aims to shed light on the interaction of culture and corporate decisions and focuses on the role of top managers. The paper also investigates the mechanism of how top management can affect corporate innovation output.Design/methodology/approachThe paper constructs the measure of individualism using the westward expansion in US history. To do so, the paper uses the US county-level duration of exposure of the frontier territory in the 19th century and links the counties to CEOs' birthplaces. The paper argues the cultural characteristics of birthplaces can affect a person's later management styles and decisions, hence affecting corporate innovation policies. Using regression and difference-in-differences estimations, the paper explores the relation and causality between cultural individualism and innovation output.FindingsThe paper finds that CEO cultural individualism is positively related with the number of patents produced by the firm and the citations received by the firm. Difference-in-differences tests using CEO turnovers support that the relation is causal. The paper also investigates the economic mechanism of how individualistic CEOs achieve such results. It finds that individualistic CEOs tend to hire more talented employees and improve the workplace environment to attract top inventors.Originality/valueThis paper provides firm-level evidence of culture and innovation. Prior studies in this area focus on cross-country evidence and suffer the limitation of confounding factors. Using a county-level measure of individualism and a sample of firms in USA, the paper alleviates the concern and provides evidence with better granularity. This paper also provides a novel mechanism for attracting top inventors, while existing literature tend to focus on risk-taking activities.
Optimization of a damper system for noise and vibration reduction in a PMSM
Authors: Ni Sijie , Bauw Grégory , Romary Raphael , Cassoret Bertrand , Le Besnerais Jean 
Published: July 2024

Purpose
This paper aims to optimize passive damper system (PDS) design by configuring its parameters to improve its performance and behavior in permanent magnet synchronous machines (PMSM).

Design/methodology/approach
First, the principle and effectiveness of the PDS are recalled. Second, the impact of different PDS parameters on its operation is analyzed. Third, a multi-objective optimization is proposed to explore a compromise design of PDS. Finally, the transient finite element method simulation is performed to validate the optimized design, which can ensure an excellent noise reduction effect and weaker negative impacts.

Findings
A suitable capacitance value in PDS is a key to realizing the damping effect. A larger copper wire can improve the noise reduction performance of PDS and reduce its Joule losses. A compromise solution obtained from a multi-objective optimization remains the excellent noise reduction and reduces Joule losses.

Originality/value
This paper explores the impact of PDS parameters on its operation and provides an orientation of PDS optimization, which is favorable to extend its application in different electrical machines.