bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluvial habitat associations of riverine dragonflies (Odonata, Gomphidae) in the Huron Mountains (Michigan, USA)
Authors: Orlofske Jessica M. , Wilson Brandon R. , Tesar Danielle E. , Tyrrell Christopher D. , Headley Rachel 
Published: July 2024

AbstractThe presence of sediment‐burrowing clubtail dragonflies (Gomphidae) may be directly related to riverine geomorphic properties. Their synchronous emergence behavior, marked by persistent exuviae, allows for the examination of emerging adult‐stage habitats. Here we explore how emerging adult and benthic larvae are related to hydrogeomorphic factors through regression modeling. Nine sites in two subwatersheds of the Huron Mountain region (Michigan, USA) were surveyed during two periods: May/June 2021 and August 2021. Temperature, pH, dissolved oxygen, conductivity, and discharge were measured concurrent with invertebrate surveys, and field samples of total suspended solids, nutrients, and substrate particle size distribution were also taken. In spring, 317 exuviae were collected, including 153 Gomphidae. In August, 45 larvae were collected including 22 Gomphidae. Spearman's rank correlations preceded robust regression analysis to aid variable selection. Although nonsignificant, Gomphidae exuviae were negatively correlated with conductivity, average water depth, and percent sand while non‐Gomphidae exuviae were positively correlated with the same variables. The model selection found the top models for Gomphidae and non‐Gomphidae exuviae abundance to relate to depth and conductivity, while the top model for Gomphidae larvae was with discharge. All single variable models (discharge, width, and percent sand) had similar AICc criterion values when examining their relationship with non‐Gomphidae larval abundance. Our study demonstrates that larvae of several riverine dragonfly taxa in the Huron Mountains co‐occur despite hydrogeomorphic variation, yet, at emergence, specific taxa may be responding to different stream properties. Understanding the habitat requirements of riverine dragonflies and how these potentially shift throughout development can support conservation efforts.
Single Nucleus Total RNA Sequencing of Formalin‐Fixed Paraffin‐Embedded Gliomas
Authors: Xu Ziye , Chen Lingchao , Lin Xin , Lyu Yuexiao , Zhou Mofei , Chen Haide , Zhang Heng , Zhang Tianyu , Chen Yu , Suo Yuanzhen , Liang Qian , Qin Zhiyong , Wang Yongcheng 
Published: July 2024

AbstractGliomas, the predominant form of brain cancer, comprise diverse malignant subtypes with limited curative therapies available. The insufficient understanding of their molecular diversity and evolutionary processes hinders the advancement of new treatments. Technical complexities associated with formalin‐fixed paraffin‐embedded (FFPE) clinical samples hinder molecular‐level analyses of gliomas. Current single‐cell RNA sequencing (scRNA‐seq) platforms are inadequate for large‐scale clinical applications. In this study, automated snRandom‐seq is developed, a high‐throughput single‐nucleus total RNA sequencing platform optimized for archival FFPE samples. This platform integrates automated single‐nucleus isolation and droplet barcoding systems with the random primer‐based scRNA‐seq chemistry, accommodating a broad spectrum of sample types. The automated snRandom‐seq is applied to analyze 116 492 single nuclei from 17 FFPE samples of various glioma subtypes, including rare clinical samples and matched primary‐recurrent glioblastomas (GBMs). The study provides comprehensive insights into the molecular characteristics of gliomas at the single‐cell level. Abundant non‐coding RNAs (ncRNAs) with distinct expression profiles across different glioma clusters and uncovered promising recurrence‐related targets and pathways in primary‐recurrent GBMs are identified. These findings establish automated snRandom‐seq as a robust tool for scRNA‐seq of FFPE samples, enabling exploration of molecular diversities and tumor evolution. This platform holds significant implications for large‐scale integrative and retrospective clinical research.
Road Target Detection in Different Weather Conditions Based on Deep Learning
Authors: Yang Zhendong , Zhao Yibing , Li Bin , Guo Lie 
Published: July 2024

AbstractAddressing the challenge of ensuring robustness in vision‐based target recognition algorithms under adverse weather conditions, such as rain, snow, and fog, is crucial. In this paper, we introduce a novel approach for road target detection that can effectively operate under various weather conditions. Our method is based on the cascade task framework of target detection, complemented by image restoration techniques. Specifically, we have developed a denoising network tailored to meet the demands of de‐raining and snow removal tasks. This network leverages prior knowledge about the mask, enhancing its effectiveness. In real‐world scenarios featuring fog, wet conditions, and snow‐covered roads, our proposed method demonstrates a significant improvement in both recall rate and accuracy compared to conventional single‐object detection algorithms. © 2024 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.
Anaesthetic mortality in cats: A worldwide analysis and risk assessment
Authors: Redondo José I. , Martínez‐Taboada Fernando , Viscasillas Jaime , Doménech Luis , Marti‐Scharfhausen Reyes , Hernández‐Magaña Eva Z. , Otero Pablo E. 
Published: July 2024

AbstractBackgroundPatient safety is essential in small animal anaesthesia. This study aimed to assess anaesthesia‐related deaths in cats worldwide, identify risk and protective factors and provide insights for clinical practice.MethodsA prospective multicentre cohort study of 14,962 cats from 198 veterinary centres across different countries was conducted. Data on anaesthesia‐related deaths, from premedication up to 48 hours postextubation, were collected. Logistic regression was used to analyse patient demographics, American Society of Anesthesiologists (ASA) classification, procedure type and anaesthetic drugs.ResultsThe anaesthesia‐related mortality was 0.63%, with 74.5% of deaths occurring postoperatively. Cats with cachexia, a higher ASA status or who underwent abdominal, orthopaedic/neurosurgical or thoracic procedures exhibited elevated mortality. Mechanical ventilation use was associated with increased mortality. Mortality odds were reduced by the use of alpha2‐agonist sedatives, pure opioids in premedication and locoregional techniques.LimitationsLimitations include non‐randomised sampling, potential biases, unquantified response rates, subjective death cause classification and limited variable analysis.ConclusionsAnaesthetic mortality in cats is significant, predominantly postoperative. Risk factors include cachexia, higher ASA status, specific procedures and mechanical ventilation. Protective factors include alpha2‐agonist sedatives, pure opioids and locoregional techniques. These findings can help improve anaesthesia safety and outcomes. However, further research is required to improve protocols, enhance data quality and minimise risks.
On the existence of symplectic barriers
Authors: Haim-Kislev Pazit , Hind Richard , Ostrover Yaron 
Published: July 2024

AbstractIn this note we establish the existence of a new type of rigidity of symplectic embeddings coming from obligatory intersections with symplectic planes. In particular, we prove that if a Euclidean ball is symplectically embedded in the Euclidean unit ball, then it must intersect a sufficiently fine grid of two-codimensional pairwise disjoint symplectic planes. Inspired by analogous terminology for Lagrangian submanifolds, we refer to these obstructions as symplectic barriers.
Combinatorics of semi-toric degenerations of Schubert varieties in type C
Authors: Fujita Naoki , Nishiyama Yuta 
Published: July 2024

AbstractAn approach to Schubert calculus is to realize Schubert classes as concrete combinatorial objects such as Schubert polynomials. Using the polytope ring of the Gelfand–Tsetlin polytopes, Kiritchenko–Smirnov–Timorin realized each Schubert class as a sum of reduced Kogan faces. The first named author introduced a generalization of reduced Kogan faces to symplectic Gelfand–Tsetlin polytopes using a semi-toric degeneration of a Schubert variety, and extended the result of Kiritchenko–Smirnov–Timorin to type C case. In this paper, we introduce a combinatorial model to this type C generalization using a kind of pipe dream with self-crossings. As an application, we prove that the type C generalization can be constructed by skew mitosis operators.
The antiarrhythmic drugs amiodarone and dronedarone inhibit intoxication of cells with pertussis toxin
Authors: Jia Jinfang , Lietz Stefanie , Barth Holger , Ernst Katharina 
Published: July 2024

AbstractPertussis toxin (PT) is a virulent factor produced by Bordetella pertussis, the causative agent of whooping cough. PT exerts its pathogenic effects by ADP-ribosylating heterotrimeric G proteins, disrupting cellular signaling pathways. Here, we investigate the potential of two antiarrhythmic drugs, amiodarone and dronedarone, in mitigating PT-induced cellular intoxication. After binding to cells, PT is endocytosed, transported from the Golgi to the endoplasmic reticulum where the enzyme subunit PTS1 is released from the transport subunit of PT. PTS1 is translocated into the cytosol where it ADP-ribosylates inhibitory α-subunit of G-protein coupled receptors (Gαi). We showed that amiodarone and dronedarone protected CHO cells and human A549 cells from PT-intoxication by analyzing the ADP-ribosylation status of Gαi. Amiodarone had no effect on PT binding to cells or in vitro enzyme activity of PTS1 but reduced the signal of PTS1 in the cell suggesting that amiodarone interferes with intracellular transport of PTS1. Moreover, dronedarone mitigated the PT-mediated effect on cAMP signaling in a cell-based bioassay. Taken together, our findings underscore the inhibitory effects of amiodarone and dronedarone on PT-induced cellular intoxication, providing valuable insights into drug repurposing for infectious disease management.
Efficacy of cognitive behavioral therapy for anxiety and depression in Parkinson’s disease patients: an updated systematic review and meta-analysis
Authors: Alnajjar Asmaa Zakria , Abouelmagd Moaz Elsayed , Krayim Abdulrahman , AbdelMeseh Maickel , Bushara Nagham , Nabil Yehia 
Published: July 2024

Abstract
Background
Parkinson’s disease (PD) patients often experience non-motor symptoms like depression and anxiety, significantly impacting their quality of life. With the limited effectiveness of pharmacological treatments, effective non-pharmacological interventions are needed. This systematic review and meta-analysis aimed to evaluate the efficacy of cognitive-behavioral therapy (CBT) in reducing depression and anxiety symptoms in PD patients.

Methods
Randomized controlled trials (RCTs) exploring CBT's effectiveness for depression and anxiety in PD patients were included. Studies published until April 2023 were identified from PubMed, Web of Science, and Scopus. Methodological quality was assessed using the Risk of Bias-2 (ROB-2) tool. Statistical analysis involved calculating the standardized mean difference (SMD) and corresponding 95% confidence intervals (CIs) using Review Manager 5.4.1.

Results
The systematic review included 12 studies involving 241 PD patients. CBT led to a substantial reduction in anxiety (SMD -0.95, 95% CI [-1.15 to -0.74], P < 0.00001) and depression (SMD -1.02, 95% CI [-1.39 to -0.65], P < 0.0001). Both traditional CBT and tele-CBT (administered over the phone or internet) were effective in treating depression and anxiety. Traditional CBT improved depression (SMD -1.16, 95% CI [-1.83 to -0.49], P < 0.00001), while tele-CBT showed comparable results (SMD -0.90, 95% CI [-1.31 to -0.48], P < 0.00001). For anxiety, both traditional CBT (SMD -0.94, 95% CI [-1.25 to -0.63], P < 0.00001) and tele-CBT (SMD -0.95, 95% CI [-1.22 to -0.67], P < 0.00001) significantly reduced symptoms.
In conclusion, this systematic review and meta-analysis demonstrated the efficacy of CBT in reducing depression and anxiety in PD patients. Healthcare providers are encouraged to integrate CBT into their treatment protocols. However, additional high-quality studies with longer-term follow-up assessments are needed to further enhance understanding in this area.

Prospero Registration
CRD42023424758.
Portable multi-focal visual evoked potential diagnostics for multiple sclerosis/optic neuritis patients
Authors: Banijamali S. Mohammad Ali , Versek Craig , Babinski Kristen , Kamarthi Sagar , Green-LaRoche Deborah , Sridhar Srinivas 
Published: July 2024

Abstract
Purpose
Multiple sclerosis (MS) is a neuro-inflammatory disease affecting the central nervous system (CNS), where the immune system targets and damages the protective myelin sheath surrounding nerve fibers, inhibiting axonal signal transmission. Demyelinating optic neuritis (ON), a common MS symptom, involves optic nerve damage. We’ve developed NeuroVEP, a portable, wireless diagnostic system that delivers visual stimuli through a smartphone in a headset and measures evoked potentials at the visual cortex from the scalp using custom electroencephalography electrodes.

Methods
Subject vision is evaluated using a short 2.5-min full-field visual evoked potentials (ffVEP) test, followed by a 12.5-min multifocal VEP (mfVEP) test. The ffVEP evaluates the integrity of the visual pathway by analyzing the P100 component from each eye, while the mfVEP evaluates 36 individual regions of the visual field for abnormalities. Extensive signal processing, feature extraction methods, and machine learning algorithms were explored for analyzing the mfVEPs. Key metrics from patients’ ffVEP results were statistically evaluated against data collected from a group of subjects with normal vision. Custom visual stimuli with simulated defects were used to validate the mfVEP results which yielded 91% accuracy of classification.

Results
20 subjects, 10 controls and 10 with MS and/or ON were tested with the NeuroVEP device and a standard-of-care (SOC) VEP testing device which delivers only ffVEP stimuli. In 91% of the cases, the ffVEP results agreed between NeuroVEP and SOC device. Where available, the NeuroVEP mfVEP results were in good agreement with Humphrey Automated Perimetry visual field analysis. The lesion locations deduced from the mfVEP data were consistent with Magnetic Resonance Imaging and Optical Coherence Tomography findings.

Conclusion
This pilot study indicates that NeuroVEP has the potential to be a reliable, portable, and objective diagnostic device for electrophysiology and visual field analysis for neuro-visual disorders.
Quantum Reconstructions as Stepping Stones Toward ψ-Doxastic Interpretations?
Authors: Berghofer Philipp 
Published: July 2024

AbstractIn quantum foundations, there is growing interest in the program of reconstructing the quantum formalism from clear physical principles. These reconstructions are formulated in an operational framework, deriving the formalism from information-theoretic principles. It has been recognized that this project is in tension with standard ψ-ontic interpretations. This paper presupposes that the quantum reconstruction program (QRP) (i) is a worthwhile project and (ii) puts pressure on ψ-ontic interpretations. Where does this leave us? Prima facie, it seems that ψ-epistemic interpretations perfectly fit the spirit of information-based reconstructions. However, ψ-epistemic interpretations, understood as saying that the wave functions represents one’s knowledge about a physical system, recently have been challenged on technical and conceptual grounds. More importantly, for some researchers working on reconstructions, the lesson of successful reconstructions is that the wave function does not represent objective facts about the world. Since knowledge is a factive concept, this speaks against epistemic interpretations. In this paper, I discuss whether ψ-doxastic interpretations constitute a reasonable alternative. My thesis is that if we want to engage QRP with ψ-doxastic interpretations, then we should aim at a reconstruction that is spelled out in non-factive experiential terms.
Beginning mathematics teachers’ values and beliefs about pedagogy during a time of policy flux
Authors: Hyde Rosalyn , Archer Rosa , Bamber Sally 
Published: July 2024

AbstractThis study interrogates how beginning secondary mathematics teachers align their beliefs with their practice when they justify their pedagogical choices in the context of recent English mathematics education policy which is strongly influenced by approaches to mathematics teaching in Shanghai and Singapore currently referred to as ‘mastery’ approaches. It seeks to understand beginning teachers’ perceptions and understandings of these approaches and the extent to which they recognise aspects of ‘mastery’ in practice. In setting the context, pre-service teachers’ beliefs were surveyed and found to be congruent with constructivist approaches to learning. We then draw on qualitative data from semi-structured interviews secondary mathematics teachers in their first year post-qualification. The interviews were designed to interrogate and capture understanding of the features of mastery within their own classrooms. By using vignettes to capture participants’ beliefs, our aim was to present a ‘more nuanced understanding of the phenomena’ (Skilling and Stylianides in Int J Res Method Educ 43(5):541–556, 2019, 10.1080/1743727x.2019.1704243). The analytical framework developed draws on Guskey’s (In: Wright J (ed) International encyclopedia of the social & behavioural sciences, 2015, vol 14, 2nd edn, Elsevier, pp 752–759) interpretation of Bloom’s theory of mastery learning together with features of mastery learning in mathematics articulated by Drury (How to teach mathematics for mastery, 2018, Oxford University Press) and Boylan et al. (Edu Sci 8(4):202, 2018, 10.3390/educsci8040202). This posed a research design challenge given the variation in interpretation of mastery learning as it is understood in practice. The data exposes differences in the interpretation of mastery approaches in the settings where they learn to teach, as well as the tensions that arise between beginning teachers’ beliefs, practice, professional knowledge and agency in their developing classroom roles.
Variations in the Central Mode Water in the North Pacific as a manifestation of the Pacific Decadal Oscillation
Authors: Naoto Iwasaka , Kobashi Fumiaki , Kawai Yoshimi 
Published: July 2024

AbstractThe North Pacific Central Mode Water (CMW) is examined from the viewpoint of its volume variations. The volume of the CMW layers thicker than $$150 m$$

150
m

is used as an index of CMW variations, which successfully represents the year-to-year and decadal variations in the CMW volume. The CMW index shows the variation close to that of the Pacific Decadal Oscillation (PDO). The CMW variation is strongly tied with large-scale, dominant variations in sea surface temperature (SST), surface dynamic height (SDH), and sea surface height (SSH) anomalies in the North Pacific, with a significant correlation with the PDO. Year-to-year and decadal variations of CMW volume in May to July are significantly correlated with the wintertime Aleutian Low and 500$$hPa$$

hPa

geopotential height variations, which indicates that the Aleutian Low induces the eastward extension/retreat of the strong winter westerlies and resultant net surface heat flux anomaly over the CMW distribution region. Thus, the CMW volume variation can be regarded as a significant manifestation of the PDO. The SST, SDH, and SSH anomalies are associated with the surface cooling in the northern sector of the CMW distribution region. On the other hand, the SDH and SSH anomalies throughout a year and the SST anomaly in the cold season in the southeastern sector of the CMW region are formed due to the heaving of isopycnal surfaces in the subsurface layer above the CMW in response to its volume variations.
Photothermal Depth Profiling of Gelatin-Stabilised Gold Nanorods-Trastuzumab Conjugate as a Potential Breast Cancer Photothermal Agent
Authors: Mwad Mbaz Gracia It , Calvin Lebepe Thabang , Maluleke Rodney , Obonai Akiyoshi , Mgedle Nande , Aladesuyi Olanrewaju A. , Kalimutu Rajendran , Kodama Tetsuya , Komiya Atsuki , Oluwafemi Oluwatobi Samuel 
Published: July 2024

AbstractGold nanorods (AuNRs) are powerful photothermal agents (PTAs) in cancer treatment due to their near-infrared laser light absorption ability. However, the cytotoxicity of AuNRs caused by the presence of cationic surfactants often used and their lack of specificity affect their application in photothermal therapy. Thus, we herein developed a bioconjugate obtained from the functionalisation of AuNRs to gelatin (Gel@AuNRs), followed by the conjugation of the as-synthesised material to a breast cancer antibody, trastuzumab (Trast-Gel@AuNRs) to address these issues. The optical and structural characterization of the as-synthesized indicated no significant changes in the optical properties of AuNRs after their functionalisation with gelatin and conjugation with the antibody. The photothermal profiling of the as-synthesised materials showed that AuNRs still have an excellent photothermal conversion efficiency (PCE) after their functionalisation (20%) and their conjugation to an antibody (19%). In addition, the In vitro photothermal depth response showed that Trast-Gel@AuNRs is a promising photothermal agent for HER2-positive breast cancer treatment.
Graphical Abstract
Susceptibility Testing of Environmental and Clinical Aspergillus sydowii Demonstrates Potent Activity of Various Antifungals
Authors: Spruijtenburg Bram , Rezusta Antonio , Houbraken Jos , Hagen Ferry , de Groot Theun , Meis Jacques F. , Meijer Eelco F. J. 
Published: July 2024

AbstractThe genus Aspergillus consists of a vast number of medically and environmentally relevant species. Aspergillus species classified in series Versicolores are ubiquitous in the environment and include the opportunistic pathogen Aspergillus sydowii, which is associated with onychomycosis and superficial skin infections. Despite frequent clinical reports of A. sydowii and related series Versicolores species, antifungal susceptibility data are scarce, hampering optimal treatment choices and subsequent patient outcomes. Here, we employed antifungal susceptibility testing (AFST) based on microbroth dilution on a set of 155 series Versicolores strains using the common antifungals amphotericin B, itraconazole, voriconazole, posaconazole, isavuconazole and micafungin with the addition of luliconazole and olorofim. All strains were identified using partial calmodulin gene sequencing, with 145 being A. sydowii, seven A. creber and three A. versicolor, using the latest taxonomic insights. Overall, tested antifungals were potent against the entire strain collection. In comparison to A. fumigatus, azole and amphotericin B MICs were slightly elevated for some strains. AFST with luliconazole and olorofim, here reported for the first time, displayed the highest in vitro activity, making these antifungals interesting alternative drugs but clinical studies are warranted for future therapeutic use.