bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome Sequence of a Canine Parvovirus Strain, CPV-s5, Prevalent in Southern China
Authors: Zhu Yiping , Huang Yongliang , Wang Yifei , Chen Keren , Niu Xuefeng , Luo Yongwen , Guo Xiaofeng 
Published: January 2014

ABSTRACT
A prevalent new field canine parvovirus type-2a (CPV-2a) strain, CPV-s5, was isolated from the feces of a dog with diarrhea in Shenzhen, China. The genome of CPV-s5 was determined and analyzed, which will facilitate further study of the molecular epidemiology and genetic diversity of CPV-2 field isolates in southern China.
Draft Genome Sequence of the Formaldehyde-Resistant Fungus
Byssochlamys spectabilis
No. 5 (Anamorph Paecilomyces variotii No. 5) (NBRC109023)
Authors: Oka Takuji , Ekino Keisuke , Fukuda Kohsai , Nomura Yoshiyuki 
Published: January 2014

ABSTRACT

Byssochlamys spectabilis
no. 5 (anamorph
Paecilomyces variotii
no. 5) (NBRC109023) was isolated from a soil sample in 2001 in Kumamoto Prefecture, Japan. This fungus is highly resistant to formaldehyde. Here, we report a draft genome sequence of
P. variotii
no. 5; this draft was produced with the intent of investigating the mechanism of formaldehyde resistance. This is the first report of the genome sequence of any
Paecilomyces
species.
Impact of a GP-led walk-in centre on NHS emergency departments
Authors: Arain M , Campbell M J , Nicholl J P 
Published: January 2014

ObjectiveTo determine the impact of the GP-led walk-in centre (WIC) in Sheffield (England) on the demand for emergency department (ED) care.MethodsA survey of patients visiting the Sheffield GP WIC was conducted over 3 weeks during September and October 2011. A short, postvisit questionnaire was also sent to those who agreed to determine if the patient had used another NHS service for the same problem. Routine data were obtained from the adult and children's EDs and minor injuries unit in Sheffield, 1 year before and 1 year after the opening of the GP WIC. A linear model of the number of minor daytime attendances (GP type) per month was used to estimate the impact of opening the GP WIC, after controlling for seasonal variation and a linear time trend.ResultsA total of 529 patients responded to the survey (response rate 51%). Based on their self-reported intentions, 64 of these patients (53 adults and 11 children) were diverted from going to ED in the 3-week survey period as a result of the establishment of the GP WIC. From this we would have expected around a 26% monthly reduction in GP-type attendances at adult ED, and 7% reduction at children's ED. However, routine data only showed an 8% (95% CI 1% to 16%) reduction at the adult ED. Reductions in GP-type attendances at the children's ED and the minor injury unit at the time of the opening of the GP WIC were also found, but were not statistically significant. The estimated impact on children's ED was a 14% reduction (95% CI −38% to 8%), and for minor injuries unit (MIU) a 4% reduction (95% CI −18 to 9%).ConclusionsThere was a statistically significant reduction in GP-type daytime attendances at the adult ED after the opening of the GP WIC. Since this reduction was not mirrored in changes in night-time attendances (when the GP WIC was closed), and our survey responses suggested some people were diverted from going to the ED, it is possible that the opening of the GP WIC caused this reduction.
Living alone and psychological well-being in mid-life: does partnership history matter?
Authors: Demey Dieter , Berrington Ann , Evandrou Maria , Falkingham Jane 
Published: January 2014

BackgroundPrevious studies have found that the duration since a union dissolution and the number of union dissolutions are associated with psychological well-being. However, these two aspects of partnership history have rarely been considered jointly in models of mental health. This study aims to investigate how the time since the most recent union dissolution and the number of union dissolutions are related to two indicators of psychological well-being—life satisfaction and the General Health Questionnaire—among middle-aged solo-living British men and women.MethodsData from the United Kingdom Household Longitudinal Study from 2009 to 2010 are analysed for 1201 50–64 year olds who were living alone and have ever been in a co-resident union (472 men and 729 women). Logistic regression analysis is used to investigate how life satisfaction and General Health Questionnaire 12 (GHQ-12) caseness are associated with partnership characteristics.ResultsGHQ-12 caseness is significantly and positively associated with the number of union dissolutions and negatively with the duration since the most recent union dissolution. This is the case among both genders, in models in which these partnership characteristics are entered separately and jointly, and in models controlling for parenthood status, socioeconomic status and physical health.ConclusionsThe results suggest that there is a short-term deterioration in mental health after a partnership break-up and that experiencing multiple union dissolutions is detrimental for psychological well-being. The association between partnership characteristics and the two measures of psychological well-being differs, which is in line with previous research showing that negative affect and life satisfaction are two separate constructs.
Prevalence of paratuberculosis in cattle and control measures within the herd influence the performance of ELISA tests
Authors: Donat K. , Schlotter K. , Erhardt G. , Brandt H. R. 
Published: January 2014

Commercial ELISA kits are widely used in the diagnosis of paratuberculosis of dairy cattle. It is critically important to understand the influences on these test results and their relation to faecal culture (FC) results in order to interpret the findings and to make decisions concerning serial testing and control measures. A total of 1021 cattle (423 FC positive, 598 FC negative) from 14 Mycobacterium avium subspecies paratuberculosis (MAP) positive herds were tested with four ELISA systems and FC simultaneously to calculate the kappa coefficients for the agreement of the different ELISA systems as well as find influencing factors. For the agreement of FC and ELISA, the kappa coefficients were low and ranged from 0.19 to 0.24, whereas, results of the different ELISA were consistently high (0.74–0.90). Agreement with FC was enhanced with the duration of control (P≤0.001) and the lactation number (P≤0.01), and reduced with within‐herd prevalence (P≤0.001). There were substantial differences in the detection rate of low (15–24 per cent) and high (85–100 per cent) MAP shedders. In conclusion, the factors shown to influence test sensitivity, should be taken into account for validation and interpretation of ELISA tests. The benefit of serial ELISA testing is low.
Automatic detection of wrinkle ridges in Venusian Magellan imagery
Authors: Barata M. T. , Lopes F. C. , Pina P. , Alves E. I. , Saraiva J. 
Published: January 2014

Abstract
Wrinkle ridges constitute one of the most abundant tectonic features on terrestrial planetary surfaces. On Venus, evidence suggests a connection between wrinkle ridges and the climatic evolution of the planet. However, like other planets and moons that experience more active surface geological processes, such as Earth, Mars, Europa, Io and Titan, visible impact craters on the Venusian surface are less common because they are eroded, buried or transformed by tectonics or other geological processes over time. It is of great importance to identify and understand some characteristics of those surface morphologies, such as orientation, length, spacing, original dimension and topography. Nevertheless, these parameters can only be computed on remotely sensed images after their segmentation. Until now, the manual identification of these features has been focused on those of major geological significance, leaving many more to be identified, mapped and studied. The main aim of this paper is to provide a method for automatic detection of wrinkle ridges from Magellan Synthetic Aperture Radar (SAR) imagery at different scales. The proposed algorithm, based on a combination of fractal dimension and morphological operators, identifies regions of interest to this study, namely those of anisotropic behaviour, but also impact craters and their ejecta blankets. The high performances achieved in a variety of situations demonstrate that its robustness can be applied to an automated procedure.
Guest Authors or Ghost Inventors? Inventorship and Authorship Attribution in Academic Science
Authors: Lissoni Francesco , Montobbio Fabio 
Published: January 2014

Background: Authorship and inventorship are the key attribution rights that contribute to a scientist’s reputation and professional achievement. This article discusses the concepts of coinventorship and coauthorship in the legal and sociological literature, as well as journals’ publication guidelines and technology transfer offices’ recommendations. It discusses also the relative importance of social and legal norms in the allocation of scientific credit. Method: This article revises critically the literature on inventorship and authorship in academic science and derives some policy implications on the institutional mechanisms allocating scientific credit. It reports and assesses the recent empirical evidence on the importance of social norms for the attribution of inventorship and authorship in teams of scientists. Finally, it discusses those norms from a social welfare perspective. Result: The social norms that regulate the distribution of authorship and inventorship do not reflect exclusively the relative contribution of each team member but also the members’ relative seniority or status. In the case of inventorship, such social norms appear to be as important as the legal norms whose respect is often invoked by technology transfer officers. Conclusion: Authorship and inventorship appear to be obsolete because they do not capture the increasing division of labor and responsibility typical of contemporary scientific research teams. The informative value of both authorship and inventorship attributions may be much more limited than assumed by recent evaluation exercises.
A Comparative Study of Clinicopathological Features Between Simple Bone Cysts of the Calcaneus and the Long Bone
Authors: Takada Jun , Hoshi Manabu , Oebisu Naoto , Ieguchi Makoto , Kakehashi Anna , Wanibuchi Hideki , Nakamura Hiroaki 
Published: January 2014

Background: The potential unrevealed clinicopathological differences between simple bone cysts situated in the calcaneus (calcaneal bone cysts) and those situated in long bones (long bone cysts) were investigated in the present study. Methods: A total of 41 cysts from 41 patients who underwent operative treatment were evaluated: 16 cysts in the calcaneus, 17 in the humerus, 7 in the femur, and 1 in the tibia. The clinical course, radiological findings, and histological features were retrospectively reviewed. Results: The mean patient age was 11.5 years (range, 3 to 25 years), and the mean follow-up was 33.0 months (range, 12 to 77 months). The mean patient age was significantly higher in patients with calcaneal bone cysts (13.5 years; long bone cysts, 10.2 years, P < .05). No treatment failure was seen for patients with calcaneal bone cysts, while 7 long bone cysts required reoperation. In H&E-stained specimens of the cyst wall, cholesterol clefts were identified in 10 of the 16 calcaneal bone cysts (62.5%), whereas none were identified in long bone cysts (0%; P < .0001). Conclusion: Our study elucidates the different clinicopathological features existing between calcaneal bone cysts and long bone cysts. Cholesterol clefting is most likely due to hemorrhaging and the subsequent breakdown of blood in the cyst. The significance of these differences between long bone and calcaneal cysts is still open to conjecture. Level of Evidence: Level III, retrospective comparative series.
The Endovascular Treatment of a Ruptured Aneurysm of the Middle Colic Artery Combined With an Isolated Dissection of Superior Mesenteric Artery
Authors: Ham Eun Mi , Cho Byung Sun , Ye Jin Bong , Mun Yun Su , Choi Young Jin , Kwon Oh Sang 
Published: January 2014

Background: Ruptured aneurysm of the middle colic artery is very rare. Its concomitance with isolated dissection of the superior mesenteric artery (SMAD) has not yet been reported in the literature. Case report: A previously well 56-year-old man was referred to our hospital with acute-onset pain throughout the entire abdomen. A ruptured aneurysm of the middle colic artery and isolated SMAD were revealed using a computed tomography (CT) scan. Coil embolization was successfully performed for a ruptured aneurysm of the middle colic artery. During the immediate postprocedural period, the patient had ischemic colitis, but he recovered in a few days with conservative treatment. Close observation was elected to address the SMAD because the condition was not thought to be responsible for any symptoms. The CT scan followed after 2 years showed no change in SMAD. Conclusions: We successfully performed endovascular treatment for a ruptured aneurysm of the middle colic artery. For the incidentally detected SMAD, close observational management was chosen.
Endovascular Stent for Iatrogenic Penetrating Injury of the Thoracic Aorta
Authors: Vagefi Parsia A. , Patel Madhukar S. , LaMuraglia Glenn M. 
Published: January 2014

Purpose: This is a report of the endovascular management of an iatrogenic descending thoracic aortic injury with long-term follow-up. Case Report: A 74-year-old medically complex female underwent the inadvertent percutaneous placement of a 6F sheath directly into the descending thoracic aorta during an attempted pericardiocentesis at an outside hospital. Upon transfer, the patient underwent endovascular placement of a thoracic stent graft to cover the entry site and recovered without incidence. The patient has remained free of complications for nearly 8 years of follow-up care. Conclusions: Endovascular stent graft utilization of the thoracic aorta has increased the treatment scope for the management of emergent and elective aortic pathology. This is particularly useful in clinical scenarios deemed too high an open surgical risk secondary to significant comorbidities.
Ascensia® WinGLUCOFACTS® Professional Software Improves Diabetes Health Outcomes
Authors: Janssen Michael , Portalatin Manuel , Wallace Jane , Zhong Weiping , Parkes Joan Lee 
Published: January 2014

Background: Traditionally, people with diabetes keep handwritten blood glucose (BG) logs. Although a useful, and a necessary component of diabetes management, logbooks can be incomplete, inaccurate and illegible, which may lead to faulty analyses of BG trends associated with meals, medications and daily activities. Ascensia®, WinGLUCOFACTS®, Professional Software (WinGLUCOFACTS) from Bayer HealthCare was developed to assist in diabetes management by providing text and graphic presentations of downloaded data. It has a unique Data Wizard™ tool that automatically identifies BG trends. Methods: A one year outcome study was conducted at Baptist Primary Care (Jacksonville, Florida) to investigate whether use of WinGLUCOFACTS would improve BG control, diabetes related behaviors, and patient knowledge and attitudes. The cost effectiveness of this software in a primary care setting was also studied. Two physicians treated both the Test Group (90 subjects) and Control Group subjects (66 subjects). The Test Group subjects' diabetes was managed using WinGLUCOFACTS in conjunction with handwritten logs. The Control Group subjects' diabetes was managed using only handwritten logs. Both groups were scheduled to visit their physician 5 times, at 3 month intervals over the course of the 12 month study. Results: Hemoglobin A1C (A1C) dropped by about half a percentage point from baseline for both Control Group (−0.48) and Test Group subjects (−0.58) at the 3 month visit, a clinically significant change. The Control Group's A1C levels, however, increased at each succeeding visit, so that at 9 and 12 months it was statistically indistinguishable from baseline, whereas the Test Group's A1C remained significantly lower than baseline (−0.64 and −0.41; 90% confidence level). Based on published methodologies for calculating cost savings related to such a sustained reduction in A1C, annual cost savings would be $75.04 to $111.54 per patient or $75,040 to $111,540 per 1000 patients. The use of WinGLUCOFACTS also had a positive effect on patients' diabetes related behaviors and on their satisfaction with their care. A majority of Test Group subjects wanted their physician to continue using WinGLUCOFACTS. The physicians expressed satisfaction with this data management system, stating that it helped them to manage the Test Group subjects' diabetes by analyzing BG trends. Conclusions: The use of Ascensia® WinGLUCOFACTS® Professional Software from Bayer HealthCare helped in the management of patients' diabetes. It improved overall glycemic control, increased their knowledge of diabetes, increased SMBG frequency, and their satisfaction with care, and was cost effective. The primary care physicians confirmed the benefit afforded by this software in the real-world management of diabetes.
Self-Monitoring of Blood Glucose Levels Requires Intensive Training for Use of Meters to Obtain Reliable and Clinically Relevant Measurements
Authors: Mohr Thomas A. , Pfützner Andreas , Forst Senait , Forst Thomas , Schöndorf Thomas 
Published: January 2014

Background: Anecdotal reports from pediatric sites have indicated that some blood glucose meters may display wrong and misleading numbers rather than error indications, when operated in deviation from the instructions for use (IFU), eg by manipulating the strip during the count-down phase. Methods: This study was performed with 60 patients with diabetes (32 female, 28 male, 21 type 1, 39 type 2, age (mean±SD): 56±11 years) who measured their blood glucose levels twice with five different blood glucose meters (Precision® Xceed™ [Abbott Medisense], Freestyle Mini™ [Abbott Medisense], Accu-Chek® Comfort [Roche Diagnostics], Accu-Chek® Aviva [Roche Diagnostics], and Ascensia Contour® [Bayer Vital]). The first measurement was performed in accordance with the IFU, and the second by manipulating the test strip using a standardised inflexion/release procedure during the count-down phase. A standard glucose oxidase method (SuperGL) served as laboratory reference. Results: All meters worked in full compliance with current accuracy standards when operated according to the IFU. When manipulating the test strip, the results varied considerably: While changes in reliability were acceptable for two devices (Precision® Xceed®, Freestyle Mini™), the other devices produced an unacceptable number of errors and a series of entirely wrong values without error indication. Conclusions: The use of all devices is recommended when used according to the IFU. The use under the artificially induced impaired testing conditions is a major concern. This study underlines the importance of appropriate patient training regarding adherence to the IFU of glucose meters.
Overview of Glycemic Control in Critical Care: Relating Performance and Clinical Results
Authors: Chase J. Geoffrey , Hann Christopher E. , Shaw Geoffrey M. , Wong Jason , Lin Jessica , Lotz Thomas , LeCompte Aaron , Lonergan Timothy 
Published: January 2014

Background: Hyperglycemia is prevalent in critical care and tight control can save lives. Current ad-hoc clinical protocols require significant clinical effort and produce highly variable results. Model-based methods can provide tight, patient specific control, while addressing practical clinical difficulties and dynamic patient evolution. However, tight control remains elusive as there is not enough understanding of the relationship between control performance and clinical outcome. Methods: The general problem and performance criteria are defined. The clinical studies performed to date using both ad-hoc titration and model-based methods are reviewed. Studies reporting mortality outcome are analysed in terms of standardized mortality ratio (SMR) and a 95th percentile (±2σ) standard error (SE95%) to enable better comparison across cohorts. Results: Model-based control trials lower blood glucose into a 72–110 mg/dL band within 10 hours, have target accuracy over 90%, produce fewer hypoglycemic episodes, and require no additional clinical intervention. Plotting SMR versus SE95% shows potentially high correlation (r=0.84) between ICU mortality and tightness of control. Summary: Model-based methods provide tighter, more adaptable one method fits all solutions, using methods that enable patient-specific modeling and control. Correlation between tightness of control and clinical outcome suggests that performance metrics, such as time in a relevant glycemic band, may provide better guidelines. Overall, compared to the current one size fits all sliding scale and ad-hoc regimens, patient-specific pharmacodynamic and pharmacokinetic model-based, or one method fits all control, utilizing computational and emerging sensor technologies, offers improved treatment and better potential outcomes when treating hyperglycemia in the highly dynamic critically ill patient.
A Model of Self-Treatment Behavior, Glucose Variability, and Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes
Authors: Breton Marc , Clarke William L , Farhy Leon , Kovatchev Boris 
Published: January 2014

Background: Type 1 diabetes patients face a lifelong behaviorally controlled optimization problem: maintaining strict glycemic control without increasing the risk of hypoglycemia. Because internal insulin secretion in type 1 diabetes (T1DM) is practically absent, this optimization is entirely dependent on the interplay among (i) self-treatment behavior, (ii) interaction between exogenous insulin and carbohydrates utilization, and (iii) internal defenses against hypoglycemia. This article presents a mathematical model and a computer simulation of the relationship among self-treatment in T1DM, blood glucose (BG) variability, and hypoglycemia-associated autonomic failure (HAAF). Method: A stochastic behavioral self-control process was coupled with a dynamical system simulation of the dampening effect of counterregulation on BG oscillations. The resulting biobehavioral control system was compared to data from a field clinical trial (85 T1DM patients, 21–62 years old, T1DM of at least 2 years duration, and at least two documented severe hypoglycemia episodes during the previous year). Results: The mathematical simulation was able to reproduce characteristics of hypoglycemic events observed during a field clinical trial, such as temporal clustering of hypoglycemic episodes associated with HAAF and occurrence of severe hypoglycemia as a result of periods of HAAF augmented by increased BG variability. Conclusion: This investigation offers a mathematical model of HAAF—the primary barrier to intensive insulin treatment. This combined modeling/computer simulation/data analysis approach explains the temporal relationship among behaviorally induced hypoglycemia, glucose variability, and autonomic failure in T1DM. This explanation is valuable not only because it indicates that signs of HAAF can be detected in patients' natural environment via self-monitoring or continuous glucose monitoring, but also because it allows for tracking of the risk of severe hypoglycemia over time.