bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Periodontal Therapy on Rheumatoid Disease Activity in Patients on Anti-Rheumatoid Drugs - A Prospective Study
Authors: Kaveri Arunachalam , Rajendran Velayudham , Jaishree Tukaram Kshirsagar , Malathi Krishnamoorthy , Kavitha Mohanasundaram 
Published: August 2024

Abstract

Aim:
The aim of this clinical trial rheumatoid arthritis–chronic periodontitis (RA-CP) is to assess the effect of non-surgical periodontal therapy in RA patients.

Materials and Methods:
Sixty RA patients taking disease-modifying anti-rheumatoid drugs (DMARD) with CP were selected from the Institute of Rheumatology, Madras Medical College, randomised into the intervention group (IG) and control group (CG). IG received non-surgical periodontal therapy after the screening visit, but CG did not receive treatment until the 3 months study period. Periodontal parameters were recorded at baseline and after 3 months for both groups. Rheumatoid Disease activity (RD activity) was assessed using disease activity score (DAS28), inclusive of tender joints count (TJC), swollen joints count (SJC), visual analog scale (VAS), and erythrocyte sedimentation rate (ESR) for both groups at baseline and after 3 months.

Results:
At the end of 3 months, IG had significant reduction in RA parameters such as tender joints count (0.0005), swollen joints count (0.0005), ESR (0.003), VAS score (0.0005), and DAS28 values (0.0005) compared to CG. Periodontal parameters at the end of 3 months were also significantly reduced in IG than in CG.

Conclusion:
Non-surgical periodontal therapy might have reduced the burden of systemic inflammatory markers, thus reducing severity of RA in IG. Reduction in tenderness and swelling of joints in the upper arm might have enabled the patients in IG to perform better oral hygiene maintenance procedures.
Immunological Study of Aborted Women Infected with Toxoplasmosis in Basrah Province
Authors: Swadi Baydaa F. , Mahdi Dawood , Mezeal Khalid 
Published: August 2024

Background:
Toxoplasmosis is regarded as one of the chief sources of miscarriage in pregnant women which caused by an apicomplexan obligatory intracellular parasites called Toxoplasma gondii. it can infect greatest kinds of warm-blooded animals, together with humans.

Aim:
Assessment some immunological parameter concentration and its relation with aborted women infected with toxoplasmosis by using ELISA method.

Methods:
A total number (155 ) of serum were collected from women aged between (16-42) years aborted women (75 seropositive with toxoplasmosis, 40 sera negative) were admitted in Basrah hospital for women and children and (40) healthy control women.

Results:
The results show the concentrations of protein S, C, anti-phospholipid and anticardiolipin (68.11, 63.17, 48.59 and 13.86) respectively with significantly than others group. The rate of strong immune factor such as anticardiolipin, protein-C, and protein-S in frequently aborted females is shown to be related to the changes.

Conclusion:
Active Toxoplasma gondii infection is more associated with miscarriage than immune factor in this group of experienced females.
Strategy to Reduce Mortality Rates of ST-elevation Acute Myocardial Infarction Using Prehospital Thrombolysis: A Meta-analysis
Authors: Ramadoss Barathkumar , Pari Arun , Santhi Sharanya Shre Ezhil , Ravi Sailatha , Ramanan Ezhilarasan 
Published: August 2024

Abstract

Importance:
Ischemic heart disease is the leading cause of death worldwide. In ST-elevation myocardial infarction (STEMI), delaying reperfusion from the onset of chest pain increases the incidence of mortality and morbidity. Prehospital thrombolysis (PHT) has been evaluated in the setting of STEMI. We performed a systematic analysis of studies of PHT in acute STEMI.

Objective:
The objective of this study was to evaluate the all-cause mortality benefit in STEMI with PHT during short-term and long-term follow-up.

Data Sources:
In December 2020, the Cochrane search strategy was used to analyze randomized control trials, nonrandomized control studies, and registry studies in PubMed, EMBASE, Cochrane Library, Google Scholar, ClinicalKey, and Clinical Trial Registries. The search was repeated, and the included studies were updated in June 2023 to include more recent literature. We restricted the analysis to full-text publications in English.

Study Selection:
Studies using any thrombolytic agent in treating acute myocardial infarction in prehospital and inhospital settings with or without percutaneous Coronary intervention (PCI) were included in the analysis. Selection criteria included patient history and symptoms, electrocardiogram findings, and cardiac markers.

Data Extraction:
We used the Cochrane Handbook for Systematic Reviews of Interventions for assessing bias, the PRISMA flow diagram to show the process of inclusion and exclusion of studies, and RevMan software to perform meta-analysis.

Main Outcomes and Measures:
Outcomes include all-cause hospital mortality rate of PHT versus inhospital thrombolysis (IHT), influence of ischemic median time on all-cause mortality with PHT, and effect of PHT before PCI. The measures must have been observed for a follow-up period of up to 35 days, 1-year, and 5-years.

Results:
Data from 63,814 patients from 32 studies were reviewed. Results indicate a reduction in all-cause mortality in patients assigned to PHT (odds ratio [OR] −0.68, P < 0.00001) compared to IHT. There was a significant reduction in mortality when thrombolytics were administered before PCI (OR − 0.78, P = 0.0001). The overall survival was better with an ischemic time of <2 h. Mortality was higher with longer ischemic time (3 h and 6 h). Among patients who presented within 2 h of the onset of chest pain, mortality was lower compared to primary PCI (pPCI).

Conclusion:
PHT offers faster reperfusion and reduces all-cause mortality compared to IHT. A strategy of PHT within the first 2-3 h of ischemic pain followed by PCI (if indicated) could offer better survival than pPCI.
HPV Vaccine and Cervical Cancer Screening Uptake among women in Abia State
Authors: Amuzie C.I. , Kalu U.K. , Izuka M.O. , Bassi A.P. 
Published: August 2024

Background: Cervical cancer is the fourth most common cancer in women, and it is associated with infection by the Human Papillomavirus (HPV). There are effective interventions for the prevention of cervical cancer. However, the uptake of these interventions by women in developing countries is poor. This study assessed the knowledge and practices of cervical cancer preventive measures and uptake of HPV vaccines among women in Abia State.
Method: This was a descriptive cross-sectional study among women in Abia State. Multistage sampling was used to recruit 700 eligible women and an ODK interviewerbased structured questionnaire was used to collect the information. Descriptive, bivariate, and multivariate analyses were done using SPSS version 26. The level of significance was set at 5%.
Results: The mean age of the respondents was 40.3 ± 9.9 years and the proportion of women with good knowledge of HPV infection and vaccine was 22.0% (95% CI: 18.9- 25.1). The uptake of Pap smear and HPV vaccine was 7% and 3%, respectively, while predictors of good knowledge for HPV infection and vaccine included higher educational status (aOR = 2.53; 95% CI: 1.73–3.71, p = 0.001), being currently married (aOR = 0.32; 95% CI: 0.18–0.54, p= 0.001) and divorced (aOR = 0.25; 95% CI: 0.13–0.49, p=0.001).
Conclusion: Poor knowledge of HPV infection and vaccines, and poor uptake of Pap smear and HPV vaccine were prevalent among the respondents. We recommend policymakers design health education programmes to improve knowledge and preventive cervical cancer practices.
Biochemical and Molecular Identification of <i>Escherichia coli</i> and <i>Salmonella spp.</i> Isolated from Milk and Fermented Milk Products Vended in Sabon-Gari and Zaria Local Government Area, Kaduna State, Nigeria
Authors: Fathuddin M.M. , Ado S.A. , Tijjani M.B. , Kazeem H.M. , Obidah J.S. , Fathuddin R. , Musa A.I. 
Published: August 2024

Salmonella spp. and Escherichia coli are two of the most prevalent food-poisoning organisms. As part of this investigation, Escherichia coli and Salmonella spp. were isolated from some fresh milk and fermented milk products in Zaria. This study aimed to investigate the prevalence and molecular characterisation of Salmonella spp. and Escherichia coli in fresh milk and fermented milk products vended Sabon-Gari and Zaria Local Government Area, Kaduna State, Nigeria. Four hundred (400) samples were used consisting of one hundred (100) samples of milk, 100 samples of Kindirimo, 100 samples of Nono, and 100 samples of yoghurt. In addition, a routine microbiological isolation detected 11% of the samples positive for Escherichia coli and 16% for Salmonella spp. All isolates were biochemically characterised and identified; however, none of the selected isolates of Escherichia coli or Salmonella spp. possessed the virulence genes rfbE or invA. Thus, 16S ribotyping was utilised to authenticate the isolates' identities as Escherichia coli strain NCCP 14540, Escherichia coli strain E57, Salmonella bongori and Salmonella enterica subsp. enterica serovar Typhimurium. However, more molecular research is required to determine which other Salmonella and Escherichia coli serotypes were present in the study region.
KARAKTERISTIK DAN STRATEGI INOVASI PENDIDIKAN
Authors: Khotima Husnul , Sartika  , Fajri Ismail  , Karoma  
Published: August 2024

A plan, technique, or sequence of actions intended to accomplish certain educational objectives is referred to as a strategy in the context of education. This essay aims to provide the idea of techniques for achieving certain learning objectives in a classroom setting. The research methodology used is library research, also known as literature study, which is a study that consults library study materials while examining a subject of interest. This research is characterized by descriptive analysis, which entails routinely analyzing the collected data and then offering clarification and insight to ensure the reader understands it fully. The research results reveal that educational innovation strategies are one of the factors that determine the success and effectiveness of social change depending on the accuracy of strategy use.
Penerapan Kurikulum Merdeka Belajar Sebagai Projek Penguatan Profil Pelajar Pancasila di Sekolah Menengah Pertama Negeri 2 Kota Padangsidimpuan
Authors: Siregar Nuryanti , Sesmiarni Zulfani , Khamim Siti , Dasopang Helmi Rostiana 
Published: August 2024

Kurikulum merdeka merupakan kurikulum alternatif yang berupaya mengatasi kemunduran pendidikan yang terjadi pada masa pandemic yang memberikan kebebasan merdeka belajar. Salah satu tujuan penerapan kurikulum merdeka ini adalah dengan melaksanakan projek penguatan profil pelajar pancasila. Penelitian ini berupaya menggambarkan penerapan kurikulum merdeka sebagai projek penguatan profil pelajar pancasila dan problematika yang dihadapi guru dalam penerapannya. Metode penelitian yang digunakan adalah kualitatif deskriftif. Instrument penelitian yang digunakan adalah wawancara, observasi, dan studi dokumentasi. Sumber data primernya adalah guru dan kepala sekolah, sedangkan sumber data skundernya adalah siswa, buku-buku yang relevan dan lain-lain. Analisis data yang digunakan adalah dengan mereduksi data, display data dan penarikan kesimpulan Lokasi penelitiannya adalah di SMP N2 Kota Padangsidimpuan. Hasil dari penelitian ini adalah bahwa di sekolah ini telah dilaksanakan kurikulum merdeka sebagai projek penguatan profil pelajar pancasila sejak tahun 2022. Tema yang di usung sesuai dengan tema yang sudah ditetapkan oleh pemerintah yaintu 6 element yang ada dalam profil pelajar pancasila. Masalah yang dihadapi guru dalam penerapan ini adalah masih kurangnya pemahaman guru tentang konsep kurikulum merdeka dan membuat bahan ajar sesuai dengan yang dinginkan oleh kurikulum merdeka.
Driving sustainable business practices in SMEs: Innovative approaches for environmental and economic synergy
Authors: Adekunle Stephen Toromade  , Njideka Rita Chiekezie  
Published: August 2024

This paper explores the integration of sustainable business practices in Small and Medium Enterprises (SMEs) and the associated benefits. It addresses the challenges SMEs face, such as financial constraints, lack of expertise, and regulatory complexities, while highlighting the opportunities through innovative approaches like energy efficiency, renewable energy, circular economy principles, and digital technologies. The paper provides policy recommendations to support SMEs, including financial incentives, education programs and simplified regulatory compliance. It concludes that innovative approaches are vital for achieving both environmental and economic synergy in SMEs, ensuring operational efficiency, cost reduction, and competitive advantage. The role of policymakers is emphasized in creating an enabling environment for SMEs to adopt sustainable practices, which is essential for a sustainable and resilient economy.
Keywords: Sustainable Practices, SMEs, Innovation, Policy Recommendations, Environmental and Economic Synergy.
Iman Besar Dalam Tubuh Mungil
Authors: Adilang Ryanto 
Published: August 2024

Children are an integral part of the process of human development and growth. Before someone enters the adult phase, he will first go through childhood. This then obliges the church to also give attention and service to not only adults, but also children. Traditional child services are part of the duties and responsibilities of the faith. The church as a collection of believers really needs to respond to this as part of the noble call of duty before God. The qualitative research method was set to be the scalpel in this study. The research approach that is considered appropriate is a descriptive research approach equipped with historical criticism as a method for interpreting biblical texts. Historical criticism is a method of interpretation that considers historical elements as material for viewing and analyzing texts. It is hoped that this research will provide constructive results for children's ministry in contemporary churches, especially in the Evangelical Christian Church in Minahasa. In addition, the results of this study will also provide a paradigm update for child servants and parents in serving Christian children.
Rainfall redistribution in subtropical Chinese forests changes over 22 years
Authors: Zhang Wanjun , Scholten Thomas , Seitz Steffen , Zhang Qianmei , Chu Guowei , Wang Linhua , Xiong Xin , Liu Juxiu 
Published: August 2024

Abstract. Rainfall redistribution through the vegetation canopy plays a key role in the hydrological cycle. Although there have been studies on the heterogeneous patterns of rainfall redistribution in some ecosystems, the understanding of this process in different stages of forest succession remains insufficient. Therefore, this study investigated the change tendency in rainfall redistribution and rainwater chemistry in a subtropical forest succession in South China, based on 22 years (2001–2022) of rainfall monitoring (740 valid events). Results showed that, at the event scale, both the throughfall ratio and the stemflow ratio in pine forest (PF) were higher than in mixed forest (MF) and broadleaf forest (BF). At the interannual scale, throughfall and stemflow of forests experienced an initial decrease followed by a subsequent increase over the entire measurement period (except stemflow of the pine forest), which reflects the trend in open rainfall. The variability in throughfall showed an increase from MF to PF to BF, and the variability in stemflow likewise showed an increase from MF to PF to BF. Changes in throughfall and stemflow in the BF are thus higher than those in the MF and PF over time. Furthermore, important differences in rainwater chemistry fluxes among the three forest types were found, changing in varying order over time. On average, total nitrogen (TN) and total phosphorus (TP) fluxes of throughfall increased from BF to MF to PF, while the potassium (K+) flux of throughfall showed a decrease from BF to MF to PF. Stemflow chemical fluxes varied less among forest types and over time, although tree species most importantly affected varying stemflow chemistry. These results show important changes in patterns of rainfall redistribution over time and that characteristic variations are driven by rainfall and forest factors. Therefore, this study provides insight into long-term rainfall redistribution processes by linking changes in rainfall spectra with a typical subtropical forest succession sequence.
A survey targeting exotic Aedes mosquito species in Central Europe, summer 2023, reveals the extensive occurrence of Aedes japonicus in Poland
Authors: Schaffner F. , Kwaśnik M. , Myczko Ł. , Rożek W. , Eritja R. , Lippert S. , Weigand A. , Werner D. , Kampen H. , Rudolf I. , Šikutová S. , Čabanová V. , Wint G.R.W. , Leszczyńska J. 
Published: August 2024

Abstract
In the frame of the entomological VectorNet network and its capacity building activities, we collected original mosquito distribution data in southern Poland and bordering areas of the Czech Republic, Germany and Slovakia, in June and September–November 2023. Because of the suspected occurrence of Aedes japonicus or Ae. koreicus in Poland, provided by a photo posted early 2022 on iNaturalist, we targeted the exotic Aedes species in our sampling strategy, but also collected data on other mosquito species. Besides some adult catches, we mainly collected mosquito immature stages from artificial and natural water containers but occasionally from other aquatic habitats. In addition, we collated citizen data and modelled the distribution of Ae. japonicus in Europe incorporating the newly collected data. During this snapshot field study, a total of 162 samples, including 139 yielding mosquitoes, were taken from 111 locations across 47 administrative units, resulting on the detection of 22 mosquito taxa. Our study provides the first substantiated records of Ae. japonicus and Anopheles petragnani in Poland (the second confirmed by molecular identification). While Ae. japonicus is clearly established over a large part of the country, no other exotic mosquito species was detected. The presence of Ae. japonicus was also confirmed at one location by four citizen records submitted to MosquitoAlert in 2023. Regarding native mosquitoes, we identified their presence in 127 species/NUTS3 combinations (113 for Poland, including a single record for An. petragnani). An updated modelling of the distribution of Ae. japonicus suggests higher environment suitability in Central and Eastern Europe than has been previously estimated. Aedes japonicus is probably widespread in the Czech Republic and Slovakia, and might soon colonise the bordering region of Ukraine. Its establishment extends the putative mosquito vector list for West Nile and Rift Valley fever viruses in Central Europe.
Perancangan Sistem Penjualan Berbasis Web Pada Percetakan Daffa Printer
Authors: Arrosid Nabil daffa 
Published: August 2024

Transaksi penjualan dan pembelian sekarang tidak hanya terpaku hanya sebatas transaksi langsung, di era sekarang banyak penjualan dengan sistem online. Dengan permasalahan tersebut maka dibuatlah sistem penjualan berbasis web pada percetakan daffa printer.
Proses pengembangan mengikuti metodologi agile, melibatkan tahapan seperti pengumpulan kebutuhan, desain sistem, pengujian, dan implementasi. Sistem ini mencakup fitur-fitur penting seperti manajemen katalog produk, pemesanan online, laporan penjualan secara online dan menghasilkan outpout nota yang bisa dicetak sebagai pdf.
Sistem ini akan dibuat menggunakan metode waterfall sdlc. Dibuat menggunakan bahasa pemrograman html css sebagai frontend atau latar depan dan php sebagai backend. Diharapkan nantinya ini bisa membantu pelaku usaha umkm ini lebih meningkatkan keuntungan di penjualanya.

Sales and purchase transactions are now not only centralized, only limited to direct transactions, in this era, many sales are done with an online system. With these problems, a web-based sales system was created for daffa printer printing.
The development process follows an agile methodology, involving stages such as requirements gathering, system design, testing, and implementation. This system includes important features such as product catalog management, online ordering, online sales reports and generate output notes that can be printed as pdf.
This system will be made using the SDLC waterfall method. Created using the HTML CSS programming language as the frontend or foreground and php as the backend. It is hoped that later this can help these MSME business actors further increase profits in their sales.
PENGARUH	TRANSPARANSI DAN AKUNTABILITAS PENGELOLAAN DANA DESA TERHADAP KINERJA PEMERINTAH DESA (STUDI PADA PEMERINTAH DESA KECAMATAN DAWUAN KABUPATEN SUBANG)
Authors: Rohaeni Siti 
Published: August 2024

This study, which examines the village government of Dawuan District, Subang Regency, attempts to ascertain the impact of accountability and transparency in village fund management on the functioning of village governments. This study employed a quantitative methodology that included a descriptive and verification approach. This approach makes use of primary data by sending out surveys. Ten villages in the Dawuan subdistrict made up the study's sample, and 47 persons participated as respondents. Purposive sampling is used in the sampling procedure. Analysis using multiple linear regression is the analytical technique employed. The study's findings demonstrate that village government performance is positively and significantly impacted by partial accountability and openness in village budget management. The functioning of the village government is positively and significantly impacted by the openness and accountability of the village fund management process.
Assessing the Impact of Vaccination Strategies and Re-infection Dynamics on Mycobacterium tuberculosis Transmission by Mathematical Modelling
Authors: Naresh Kumar Jothi  
Published: August 2024

In this work, we investigated the consequences of an inadequate vaccination along with other exogenous variables such as treatment-associated re-infection and re-infection among former patients. Our models represent six stages: Susceptible population, Vaccinated population, latently infected population, Rate of induced population, Quarantine population and Rate of recover population. In this model, we find out disease-free equilibrium points, reproduction number R_0 is used to control the re-infection rate in the population. Furthermore, the results suggest that even a subpar Mycobacterium tuberculosis vaccine is always successful at reducing the spread of infectious diseases among the population, even though its general effect improves with greater efficacy and penetration. It is demonstrated that a small percentage of the overall population receives immunization in a stable state and vaccine efficacy plays an equal part in decreasing the burden of disease. Based on the numerical simulation, the establishment of the TB disease is decrease and control by the vaccination coverage and efficacy of the treatment. Using an imperfect vaccine can control mycobacterium in the population. The next-generation matrix approach was utilized to determine the effective reproduction number of the proposed system. The utilization of the exponential theory which provided the disease-free equilibrium is stable and coexists endemic equilibrium point. The Lyapunov function were used to determine the disease is globally asymptotically stable. We find out the non-negative (in variant region). We used random data in MATLAB to figure out the result of the model.
A Fuzzy Log-Normal Distribution Model for the Rainfall level of Namakkal District
Authors: Prakasam. S  
Published: August 2024

Models of mathematics can accurately and precisely obtain solutions to many complex unsolvable problems in all fields. In this paper using a few mathematical models we can take the rainfall levels in Namakkal district from 2014 to 2018 and find the highest rainfall year by the fuzzy mean and the fuzzy variance in the Log-Normal distribution.