bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomy of Scholarly Collaboration in Engineering Education: A Big‐Data Bibliometric Analysis
Authors: Xian Hanjun , Madhavan Krishna 
Published: June 2014

AbstractBackgroundEngineering education has become a large community with an increasing number of scholars and publications. As the number of publications has grown, it has become increasingly difficult to understand the epistemic nature and diffusion characteristics of knowledge generated by this community. Techniques to study community topology require nontrivial computational workflows.Purpose/HypothesisThe present study characterizes the topology of scholarly collaboration and important factors affecting this topology in engineering education research.Design/MethodsA bibliometric analysis was conducted of 24,172 papers in engineering education research journals and conference proceedings for the years 2000–2011. A total of	29,116 unique authors are present. Social network analyses were used to characterize the network topology of overall scientific collaboration. Analyses based on grouping scholars by disciplinary backgrounds, research areas, and geographical locations were performed.ResultsThe results show that the engineering education research community is in its early stage of forming a small‐world network that relies primarily on 5% of scholars to build capacity. Typical small‐world networks provide some very clear characterizations about the state, stability, and growth of the community. Deviations from this ideal model suggest the need for rethinking collaboration in engineering education. Scholars with interdisciplinary backgrounds play a critical role in bridging isolated research teams.ConclusionsCompared with other disciplines and the ideal small‐world network model, the topology of collaboration in engineering education shows significant barriers to the fast diffusion of innovations. This study demonstrates the value of big‐data bibliometrics in understanding scholarly collaboration within a research community.
Predictors of respiratory epithelial adenomatoid hamartomas of the olfactory clefts in patients with nasal polyposis
Authors: Nguyen Duc T. , Nguyen‐Thi Phi‐Linh , Gauchotte Guillaume , Arous Fabien , Vignaud Jean M. , Jankowski Roger 
Published: June 2014

Objectives/HypothesisTo look for predictors of respiratory epithelial adenomatoid hamartomas (REAH) development in patients operated for nasal polyposis (NP) by adjusting on confounding factors.Study DesignProspective study.MethodsOne hundred and six patients with NP, endoscopically operated between September 2009 and March 2012 on the ethmoidal labyrinths and olfactory clefts, were enrolled in this study. Clinical data was collected 1 day prior to surgery by using a standard grid without knowledge of any histological features. Patients were then divided into two groups based on operative and pathological reports: with and without REAH in the olfactory cleft (REAH‐OC). The multivariate logistic regression model was used to assess independent factors linked to the presence of REAH‐OC in patients with NP.ResultsThe mean duration of NP disease in patients with REAH‐OC was about 13.95 ± 10.8 years versus 5.7 ± 5.6 years in patients without REAH‐OC (P < 0.0001). Seventy‐four percent of patients with REAH‐OC had undergone one or more NP‐related surgeries in their lifetime, in contrast with 49.21% of patients without REAH‐OC (P = 0.009). According to the multivariate logistic regression analysis, those patients experiencing NP ≥ 10 years (OR 4.0, 95% CI 1.304–12.062, P = 0.015) and those with asthma (OR 2.5, 95% CI 1.004–6.29, P < 0.05) were at an increased risk of developing REAH‐OC.ConclusionThe development of REAH in patients with NP appears as a specific disease of the mucosa of the OC, induced by a long‐lasting and/or severe inflammation of the olfactory clefts.Level of Evidence4. Laryngoscope, 124:2461–2465, 2014
Contrast‐enhanced ultrasound‐guided Sentinel lymph node biopsy of the ocular conjunctiva
Authors: Rabinowitz Mindy R. , Merton Daniel A. , Liu Ji‐Bin , Saxena Shivam , Pluta John , Eisenbrey John R. , Baker Adam L. , Rabinowitz Michael P. , Lally Sara , Cognetti David , Goldberg Barry B. , Pribitkin Edmund A. , Curry Joseph M. 
Published: June 2014

Objectives/HypothesisSentinel lymph node biopsy (SLNB) has been utilized for cutaneous melanoma and other malignancies arising from the eye and ocular adnexa. Currently, SLNB requires blue dyes and/or radiopharmaceuticals; both of which have significant shortcomings. This study sought to evaluate the feasibility of SLNB with the use of real‐time, contrast‐enhanced ultrasound (CEUS) as an alternative technique for tumors arising in the conjunctiva.Study DesignProspective feasibility study in a porcine model.MethodsTwelve experiments were performed on six non–tumor‐bearing Yorkshire swine. An ultrasound contrast agent, Sonazoid (GE Healthcare, Oslo, Norway), 99mtechnetium (99mTc), and methylene blue (MB) (Covidien, Mansfield, MA) were injected in the ocular conjunctiva. Sentinel lymph nodes (SLNs) were localized with CEUS and findings were compared to that of MB and 99mTc. Fisher exact test was used.ResultsContrast‐enhanced SLNs were identified within an average of 6.2 minutes from time of injection of Sonazoid. A total of 17 SLNs were identified by at least one of the three techniques. Correlation between Sonazoid and 99mTc was 94.1% (16/17 SLNs). Correlation between 99mTc and MB was 88.2% (15/17). One SLN that was positive for 99mTc but negative for Sonazoid and was considered to be a false positive (1/17); findings were similar for MB (1/17). Differences between the three techniques were not significant (P = .886).ConclusionsCEUS‐guided injection of conjunctiva for SLNB is technically feasible and correlates well with standard detection techniques. This technique shows promise for rapid, real‐time, intraoperative imaging for SLNB, using a widely available imaging modality and avoiding the need for radiopharmaceuticals.Level of EvidenceNA Laryngoscope, 124:2531–2536, 2014
Network Analysis of Publications on Topological Indices from the Web of Science
Authors: Bodlaj Jernej , Batagelj Vladimir 
Published: June 2014

AbstractIn this paper we analyze a collection of bibliographic networks, constructed from the data from the Web of Science on works (papers, books, etc.) on the topic of topological indices and on relating scientific fields. We present the general outlook and more specific findings about authors, works and journals, subtopics and keywords and also important relations between them based on scientometric approaches like the strongest and main citation paths, the main themes on citation path based on keywords, results of co‐authorship analysis in form of the most prominent islands of citing authors, groups of collaborating authors, two‐mode cores of authors and works. We investigate the nature of citing of authors, important journals and citing of works between them, journals preferred by authors and expose hierarchy of similar collaborating authors, based on keywords they use. We perform temporal analysis on one important journal as well. We give a comprehensive scientometric insight into the field of topological indices.
BioGPS: The Music for the Chemo‐ and Bioinformatics Walzer
Authors: Siragusa Lydia , Spyrakis Francesca , Goracci Laura , Cross Simon , Cruciani Gabriele 
Published: June 2014

AbstractIdentifying cross‐relationships among protein binding sites is becoming increasingly important in the chemo‐ and bioinformatics field; indeed, protein structural similarity might provide the right answer to a number of questions including Is a drug repurposable for another target? What is the molecular mechanism of a drug side‐effect? How can we improve the ligand selectivity? The comparison of protein binding sites in terms of their three‐dimensional structure molecular interaction fields can be a useful technique to approach all of these problems. Here, we report a semi‐automated method for comparing and clustering protein pockets, called BioGPS, that combines the GRID Molecular Interactions Fields (MIFs) with FLAP pharmacophoric fingerprints. BioGPS identifies and compares protein binding sites by aligning them each other and directly comparing their MIFs. The strengths of this approach are that it is MIF‐based, and therefore describes molecular interactions from a ligand perspective, and it is independent of protein superposition or sequence alignment. This approach enables protein‐protein virtual screening (drug repurposing, polypharmacology, off‐target effects), and also clustering to relate sequence‐based similarities to structure‐based differences among protein binding sites.
An algorithm for the topology optimization of geometrically nonlinear structures
Authors: Gomes Francisco A.M. , Senne Thadeu A. 
Published: June 2014

SUMMARYMost papers on topology optimization consider that there is a linear relation between the strains and displacements of the structure, implicitly assuming that the displacements of the structure are small. However, when the external loads applied to the structure are large, the displacements also become large, so it is necessary to suppose that there is a nonlinear relation between strains and displacements. In this case, we say that the structure is geometrically nonlinear. In practice, this means that the linear system that needs to be solved each time the objective function of the problem is evaluated is replaced by an ill‐conditioned nonlinear system of equations. Moreover, the stiffness matrix and the derivatives of the problem also become harder to compute.The objective of this work is to solve topology optimization problems under large displacements through a new optimization algorithm, named sequential piecewise linear programming. This method relies on the solution of convex piecewise linear programming subproblems that include second order information about the objective function. To speed up the algorithm, these subproblems are converted into linear programming ones. The new algorithm is not only globally convergent to stationary points but our numerical experiments also show that it is efficient and robust. Copyright © 2014 John Wiley & Sons, Ltd.
Reliability of the Senior Fitness Test in Community‐dwelling Older People with Cognitive Impairment
Authors: Hesseberg Karin , Bentzen Hege , Bergland Astrid 
Published: June 2014

AbstractBackground and PurposeIn older people with cognitive impairment, we require reliable and valid measures to assess physical fitness and to measure change, for example, as a result of an exercise intervention. The purpose of our study was to determine the relative and absolute test–retest reliability of the Senior Fitness Test (SFT) in older people with cognitive impairment.MethodsA test–retest reliability study was conducted for the Senior Fitness Test in older people with cognitive impairment. Participants were tested at two time points with a time interval of 24 hours to 1 week between tests. The Intraclass Correlation Coefficient model 3.1 (ICC, 3.1) with 95% confidence intervals (CIs) was used as a measure of relative reliability. The standard error of measurement and minimal detectable change (MDC) were used to measure absolute reliability.ResultsThe ICC reflected very high reliability (0.93–0.98) in all SFT items, indicating that there was no systematic error in the measurements. MDC values at the 90% CIs were calculated: chair stand test = 2.0 repetitions, armcurl test = 2.3 repetitions, chair sit and reach test = 6.0 cm, back scratch test = 4.6 cm, 2.45‐m up‐and‐go test = 1.4 seconds and 6‐minute walk test = 37.1 metres.DiscussionThe SFT battery showed high to very high test–retest reliability and thus may be suitable for detecting changes in physical fitness and evaluating physical fitness in older people with cognitive impairment, both in research and for clinical purposes. Copyright © 2014 John Wiley & Sons, Ltd.
Assessment of the effect of potential antifibrotic compounds on total and αVβ6 integrin‐mediated TGF‐β activation
Authors: Porte Joanne , Jenkins Gisli 
Published: June 2014

AbstractTransforming growth factor‐β (TGF‐β) plays an important role in the development of tissue fibrosis, and molecules inhibiting this pathway are attractive therapeutic targets for fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). Activation of TGF‐β is the rate‐limiting step in TGF‐β bioavailability, and activation by the αVβ6 integrin is important in fibrosis of the lung, liver, and kidney. Activation of TGF‐β by αVβ6 requires direct cell–cell contact and measurable release of active TGF‐β in extracellular fluid compartments does not reflect tissue specific activation. The aim of this study was to determine the effect of antifibrotic compounds on both total, and specific αVβ6 integrin‐mediated TGF‐β activity. Using a transformed mink lung cell (TMLC) TGF‐β reporter, the effects of potential antifibrotic therapies including an activin‐like kinase (Alk5) inhibitor, Dexamethasone, Pirfenidone, N‐acetylcysteine (NAC), and BIBF1120 were assessed. Effects due to αVβ6 integrin‐mediated TGF‐β activity were measured using reporter cells cocultured with cells expressing αVβ6 integrins. These high‐throughput studies were validated using a phosphorylated Smad2 Enzyme‐Linked Immunosorbent Assay. Alk5 inhibitors are potent inhibitors of TGF‐β activity, whereas the novel antifibrotics, Pirfenidone, BIBF1120, and NAC are only moderate inhibitors, and Dexamethasone does not specifically affect TGF‐βactivity, but inhibits TGF‐β‐induced gene expression. None of the current small molecular inhibitors inhibit αVβ6‐mediated TGF‐β activity. These results demonstrate the potential of this high‐throughput assay of αVβ6‐specific TGF‐β activity and illustrate that currently available antifibrotics have limited effects on αVβ6 integrin‐mediated TGF‐β activity.
Estimating the development of the fennel aphid,Hyadaphis foeniculi(Passerini) (Hemiptera: Aphiididae), using non‐linear models
Authors: Malaquias José B , Ramalho Francisco S , Lira Aline CS , Oliveira Flávia Q , Fernandes Francisco S , Zanuncio José C , Godoy Wesley AC 
Published: June 2014

AbstractBACKGROUNDNon‐linear models making it possible to predict agricultural pest outbreaks and optimise control tactics are of primary importance for integrated pest management. The development period for immature stages of the fennel aphidHyadaphis foeniculi(Passerini) (Hemiptera: Aphididae) at constant temperatures was modelled in order to determine mathematical functions for simulating the aphid's development. Non‐linear models were used to describe the relationship between temperature and development rates ofH. foeniculisubjected to constant temperatures.RESULTSThe models used were found to be good fits for estimatingH. foeniculidevelopment rates as a function of temperature, with the exception of the Davidson model. The development time ofH. foeniculinymphs ranged from 2.73 days (first instar) to 6.18 days (fourth instar) at 15 °C, from 2.57 days (first instar) to 4.52 days (fourth instar) at 20 °C and from 1.53 days (first instar) to 2.05 days (fourth instar) at 28 °C.CONCLUSIONThese models provide important tools for better elucidation of the relationship between temperature and development rates inH. foeniculi. The results could be used for predicting the occurrence of the various immature stages ofH. foeniculiin the fennel crop in Brazil, making it possible to predict more accurately the best periods for implementing pest control. © 2014 Society of Chemical Industry
Phenotypic effect and chromosomal localization of Ddw3, the dominant dwarfing gene in rye (Secale cereale L.)
Authors: Stojałowski Stefan , Myśków Beata , Hanek Monika 
Published: June 2014

AbstractDwarfing genes play a major role in development of semi-dwarf cultivars of various cereals, but in rye this type of cultivar is still not common. Several recessive and dominant dwarfing genes in rye have been reported. Among the known dominant dwarfing genes in rye, two are well characterised: Ddw1 from the 5RL chromosome and Ddw2 located on 7R. This study was aimed at characterisation of the K11 source of dominantly inherited dwarfism found in plant materials grown in the Plant Breeding and Acclimatization Institute (Radzików, Poland). Mapping analyses in this study indicate that the dominant dwarf gene under investigation is located on the 1RL chromosome and is independent from previously known genes. The gene was named Ddw3. Phenotypic effect of the Ddw3 was tested on two pairs of near-isogenic lines. Six morphological traits were analysed in two or three growing seasons: plant height, length of the second internode from the base, number of internodes, tillering, spike length, and number of spikelets per spike. No negative or weak influences on yield-related traits were observed. The examination of the dwarf plants’ reaction to seedling treatment by gibberellic acid solution revealed sensitivity of Ddw3 to this growth regulator. This report is the first evidence of the dominant Ddw3 gene in rye and its presence on the 1R chromosome.
An outcome evaluation of the implementation of the Outward Bound Singapore five‐day “intercept” program
Authors: Ang Rebecca P. , Farihah Nurul , Lau Steven 
Published: June 2014

ABSTRACTThe present study evaluated an Outward Bound Singapore five‐day “intercept” program for 136 adolescent participants, aimed at addressing frequent deliberate truancy and absenteeism from school and within‐school extracurricular activities using a quasi‐experimental design with a matched no‐treatment comparison group. Findings suggested that there is some preliminary evidence that such a program could yield positive outcomes in terms of adolescents being more behaviorally engaged in school as demonstrated by improved attendance of both academic and non‐academic activities up to 3 months after the conclusion of the intervention program. Goal setting had a short‐term positive effect with intervention participants improving significantly more so than comparison participants at 1‐month post intervention but not at 3‐month follow up. For problem solving, although the intervention group participants improved more than comparison participants at both 1‐month post intervention and at 3‐month follow up, these effects were not statistically significant. Research and practice implications were discussed.
The relations between interpersonal self‐support traits and emotion regulation strategies: A longitudinal study☆
Authors: Xia Ling‐Xiang , Gao Xin , Wang Qian , Hollon Steven D. 
Published: June 2014

ABSTRACTAlthough several cross‐sectional surveys have shown that certain traits such as extraversion and neuroticism are related to emotion regulation, few studies have explored the nature of this relationship. The present study tried to explore the longitudinal relation between traits and emotion regulation strategies. The Interpersonal Self‐Support Scale for Middle School Students (ISSS‐MSS) and the Emotion Regulation Questionnaire (ERQ) were administrated to 374 middle school students two times across a 6‐month interval. A path analysis via structural equation modeling of the five interpersonal self‐support traits and the two emotion regulation strategies was tested. The results showed that interpersonal independence predicted expressive suppression and cognitive reappraisal, and that interpersonal initiative also predicted reappraisal, while reappraisal predicted interpersonal flexibility and interpersonal openness 6 month later. These results support the hypotheses that some personality traits influence certain emotion regulation strategies, while other traits may be influenced by specific emotion regulation strategies.
Exercise Limitation of Acetazolamide at Altitude (3459 m)
Authors: Bradwell Arthur R. , Myers Stephen D. , Beazley Maggie , Ashdown Kimberly , Harris Nick G. , Bradwell Susie B. , Goodhart Jamie , Imray Chris H. , Wimalasena Yashvi , Edsell Mark E. , Pattinson Kyle T.S. , Wright Alex D. , Harris Stephen J. 
Published: June 2014

Objective To assess the effect of acetazolamide (Az) on exercise performance during early acclimatization to altitude. Methods Az (250 mg twice daily) or placebo was administered for 3 days in a double-blind, randomized manner followed by a rapid ascent to 3459 m in the Italian Alps. Twenty healthy adults (age range, 18–67 years) were tested at 60% of sea-level peak power output for 15 minutes on a bicycle ergometer after 16 to 27 hours of altitude exposure. Exercise performance was measured in relation to peripheral oxygen saturations measured from pulse oximetry (Spo2), Lake Louise acute mountain sickness (AMS) score, and perceived difficulty. Results At altitude, resting Spo2 was higher in the Az group compared with placebo ( P < .001). The highest AMS scores were in 4 of the placebo individuals with the lowest resting Spo2 ( P < .05). During the exercise test, Spo2 fell in all but 1 subject ( P < .001) and was reduced more in the Az group ( P < .01). Four Az and 1 placebo subject were unable to complete the exercise test; 4 of these 5 had the largest fall in Spo2. The perception of exercise difficulty was higher in the Az subjects compared with those taking the placebo ( P < .01). There was an age relationship with exercise limitation; 4 of the 9 older than 50 years failed to complete the test whereas only 1 of 11 younger than 50 years failed, and there were no failures in the 6 younger than 30 years ( P < .05). Conclusions In this study group, and despite higher resting Spo2, Az may have compromised exercise at 3459 m altitude during early acclimatization, particularly in older subjects.
Sleeping in Moderate Hypoxia at Home for Prevention of Acute Mountain Sickness (AMS): A Placebo-Controlled, Randomized Double-Blind Study
Authors: Dehnert Christoph , Böhm Astrid , Grigoriev Igor , Menold Elmar , Bärtsch Peter 
Published: June 2014

Objective Acclimatization at natural altitude effectively prevents acute mountain sickness (AMS). It is, however, unknown whether prevention of AMS is also possible by only sleeping in normobaric hypoxia. Methods In a placebo-controlled, double-blind study 76 healthy unacclimatized male subjects, aged 18 to 50 years, slept for 14 consecutive nights at either a fractional inspired oxygen (Fio2) of 0.14 to 0.15 (average target altitude 3043 m; treatment group) or 0.209 (control group). Four days later, AMS scores and incidence of AMS were assessed during a 20-hour exposure in normobaric hypoxia at Fio2 = 0.12 (equivalent to 4500 m). Results Because of technical problems with the nitrogen generators, target altitude was not achieved in the tents and only 21 of 37 subjects slept at an average altitude considered sufficient for acclimatization (>2200 m; average, 2600 m). Therefore, in a subgroup analysis these subjects were compared with the 21 subjects of the control group with the lowest sleeping altitude. This analysis showed a significantly lower AMS-C score (0.38; 95% CI, 0.21 to 0.54) vs 1.10; 95% CI, 0.57 to 1.62; P = .04) and lower Lake Louise Score (3.1; 95% CI, 2.2 to 4.1 vs 5.1; 95% CI, 3.6 to 6.6; P = .07) for the treatment subgroup. The incidence of AMS defined as an AMS-C score greater than 0.70 was also significantly lower (14% vs 52%; P < .01). Conclusions Sleeping 14 consecutive nights in normobaric hypoxia (equivalent to 2600 m) reduced symptoms and incidence of AMS 4 days later on exposure to 4500 m.