bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study
Authors: Amit Moran , Binenbaum Yoav , Sharma Kanika , Ramer Naomi , Ramer Ilana , Agbetoba Abib , Miles Brett , Yang Xinjie , Lei Delin , Bjøerndal Kristine , Godballe Christian , Mücke Thomas , Wolff Klaus‐Dietrich , Fliss Dan , Eckardt André M. , Copelli Chiara , Sesenna Enrico , Palmer Frank , Patel Snehal , Gil Ziv 
Published: June 2013

AbstractBackgroundAdenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure.MethodsAn international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide.ResultsFive‐year overall‐survival (OS), disease‐specific survival (DSS), and disease‐free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases.ConclusionThe clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 998–1004, 2014
Nigerasterols A and B, Antiproliferative Sterols from the Mangrove‐Derived Endophytic Fungus Aspergillus niger MA‐132
Authors: Liu Dong , Li Xiao‐Ming , Li Chun‐Shun , Wang Bin‐Gui 
Published: June 2013

AbstractTwo new 6,8(14),22‐hexadehydro‐5α,9α‐epidioxy‐3,15‐dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA‐132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9‐epidioxy‐sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay.
Triterpenoids from the Roots of Camellia oleifera C.Abel and Their Cytotoxic Activities
Authors: Wang Shou‐Li , Chen Zhong , Tong Xiao‐Jing , Liu Yan‐Li , Li Xia , Xu Qiong‐Ming , Li Xiao‐Ran , Yang Shi‐Lin 
Published: June 2013

AbstractThree new triterpenoids, 21β,22α‐diangeloyloxy‐3β,15α,16α,28‐tetrahydroxyolean‐12‐en‐23‐al (1), 21β‐angeloyloxy‐3β,15α,16α,28‐tetrahydroxy‐22α‐(2‐methylbutanoyloxy)olean‐12‐en‐23‐al (2), and 21β‐angeloyloxy‐3β,16α,28‐trihydroxy‐22α‐(2‐methylbutanoyloxy)olean‐12‐en‐23‐al (3), along with six known triterpenoids, were isolated from the roots of Camellia oleifera C.Abel. The structures of compounds 1–3 were elucidated on the basis of spectroscopic analyses. Moreover, all compounds isolated were evaluated for their cytotoxic activities by MTT (=3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide) assay.
Primary Studies on Variation in Position of Trifluoromethyl Groups in Several Aromatic Group‐14 Derivatives by 19F‐NMR Spectroscopy
Authors: Xue Bao Yu , Dillon Keith B. 
Published: June 2013

AbstractVariation in the position of CF3 groups in several aromatic Group‐14 compounds was studied by 19F‐NMR spectroscopy. In these compounds RnECl4−n (n=1 or 2; E=Si, Ge, or Sn; R=2,4,6‐(CF3)3C6H2 (=Ar), 2,6‐(CF3)2C6H3 (=Ar′), or 2,4‐(CF3)2C6H3 (=Ar″)), Ar, Ar′, and Ar″ are all bulky, strongly electron‐withdrawing ligands. The 19F‐NMR studies of the variation in position of the CF3 substituents in these compounds as revealed by chemical shifts could be correlated with the electronegativities of the central elements E, and with intramolecular E–F interactions derived from single‐crystal X‐ray diffraction data. These interactions are considered to play an important role in the stabilization of these compounds.
Formation of cine‐Substitution Products in the SuzukiMiyaura Cross‐Coupling Reaction Catalyzed by Dinuclear Palladium Complexes
Authors: Tsukada Naofumi , Abe Tsubasa , Inoue Yoshio 
Published: June 2013

AbstractThe SuzukiMiyaura coupling reaction catalyzed by dinuclear palladium complexes gave cine‐substitution products along with ordinary ipso‐substitution products. In the reaction in (D6)benzene, the ipso position of the cine‐substitution product was highly deuterated. The H/D exchange also occurred in various positions of benzene rings.
Two New Lycopodium Alkaloids from Lycopodium obscurum
Authors: Pan Ke , Luo Jian‐Guang , Kong Ling‐Yi 
Published: June 2013

AbstractTwo new Lycopodium alkaloids, (+)‐cermizine D N‐oxide (1) and (8β)‐8‐(acetyloxy)obscurumine A (2), along with five known compounds, were isolated from the crude alkaloid portion of Lycopodium obscurum. Their structures were elucidated on the basis of spectroscopic data and chemical correlation. All of these alkaloids were tested in an assay for acetylcholine esterase (AChE) inhibitory activity.
Antibacterial activity and cytocompatibility of Cu–Ti–O nanotubes
Authors: Hang Ruiqiang , Gao Ang , Huang Xiaobo , Wang Xiaoguang , Zhang Xiangyu , Qin Lin , Tang Bin 
Published: June 2013

AbstractTiO2 nanotubes (NTs) have favorable biological properties, but the poor antibacterial activity limits their application especially in orthopedics fields. In this article, Cu–Ti–O nanotubes with different Cu contents are fabricated on sputtered TiCu films. Scanning electron microscopy reveals the NTs can be formed on sputtered TiCu films when the Cu content is less than 14.6 at %. X‐ray photoelectron spectroscopy results indicate the NTs are consist of CuO mixed with TiO2 and the Cu content in NTs decreases dramatically compared with that in TiCu films. Biological experiments show that although these NTs have poor release antibacterial activity, their contact antibacterial activity has proven to be excellent, indicating the NT surface can effectively inhibit biomaterial‐associated infections. The cytocompatibility of the NTs is closely related to the Cu content and when its content is relatively low (1.01 at %), there is no appreciable cytotoxicity. So Cu–Ti–O NTs with 1 at % Cu may be suitable to achieve proper antibacterial activity and desired cytocompatibility. The Cu–Ti–O NTs integrate the favorable antibacterial activity of Cu and excellent biological properties of TiO2 NTs therefore have potential applications in orthopedics, dentistry, and other biomedical fields. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1850–1858, 2014.
Naproxen and Cromolyn as New Glycogen Synthase Kinase 3β Inhibitors for Amelioration of Diabetes and Obesity: An Investigation by Docking Simulation and Subsequent In Vitro/In Vivo Biochemical Evaluation
Authors: Motawi Tarek M. K. , Bustanji Yasser , EL‐Maraghy Shohda A. , Taha Mutasem O. , Al Ghussein Mohamed A. S. 
Published: June 2013

ABSTRACTNaproxen and cromolyn were investigated as new inhibitors of glycogen synthase kinase‐3β (GSK‐3β) in an attempt to explain their hypoglycemic properties. Study included simulated docking experiments, in vitro enzyme inhibition assay, and in vivo validations. Both drugs not only were optimally fitted within a GSK‐3β binding pocket via several attractive interactions with key amino acids but also exhibited potent in vitro enzymatic inhibitory activities of IC50 1.5 and 2.0 µM for naproxen and cromolyn, respectively. In vivo experiments illustrated that both drugs significantly reduced serum glucose and increased hepatic glycogen‐ and serum insulin levels in normal and type II diabetic Balb/c mice models. In obese animal model, both drugs exhibited significant reduction in mice weights, serum glucose, and resistin levels along with significant elevation in serum insulin, C‐peptide, and adiponectin values. It can be concluded that naproxen and cromolyn are novel GSK‐3β inhibitors and can help in management of diabetes and obesity. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:425–436, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21503
Big Data: Implications for Financial Managers
Authors: Fanning Kurt , Grant Rita 
Published: June 2013

Abstract“Big data” goes beyond the critical data that companies traditionally used to make business decisions. It includes a huge and growing amount of less‐structured data from enterprise resource planning (ERP) systems, customer relationship management (CRM) programs, social media, and other sources. Some pundits attributed Barack Obama's 2012 election win to his party's ability to analyze and work with big data. Those who accurately predicted the wayward path of Superstorm Sandy used big data to do it. And in 2011, the latest year that we have statistics for, savvy venture capital investors poured $24.7 billion into big data firms. So it's a safe bet that financial managers who can derive actionable information from big data will be able to achieve more corporate growth by making better decisions. How can you use big data to benefit your company? The authors of this article take a close look at what big data means for financial managers. © 2013 Wiley Periodicals, Inc.
Moving Forward With IT: A Framework for Success
Authors: Friedman Mark , Akaaboune Ouadie , Shim Young Soo 
Published: June 2013

AbstractToday companies are struggling to secure a sustainable competitive advantage in a market that is relentlessly more and more competitive. Traditional strategies, like cutting costs and expanding market share, have produced only minimal results. And ominously, these approaches are criticized for being guided by nonrelevant information produced by a firm's information technology (IT) system. But the authors of this article believe there is still a business empowerment role for the chief information officer (CIO)—by expanding IT services. And the authors give a step‐by‐step plan to make a company more competitive in this tough market by using a more advanced approach to IT management. © 2013 Wiley Periodicals, Inc.
Insights into magma and fluid transfer at Mount Etna by a multiparametric approach: A model of the events leading to the 2011 eruptive cycle
Authors: Patanè D. , Aiuppa A. , Aloisi M. , Behncke B. , Cannata A. , Coltelli M. , Di Grazia G. , Gambino S. , Gurrieri S. , Mattia M. , Salerno G. 
Published: June 2013

AbstractSince the second half of the 1990s, the eruptive activity of Mount Etna has provided evidence that both explosive and effusive eruptions display periodic variations in discharge and eruption style. In this work, a multiparametric approach, consisting of comparing volcanological, geophysical, and geochemical data, was applied to explore the volcano's dynamics during 2009–2011. In particular, temporal and/or spatial variations of seismicity (volcano‐tectonic earthquakes, volcanic tremor, and long‐period and very long period events), ground deformation (GPS and tiltmeter data), and geochemistry (SO2 flux, CO2 flux, CO2/SO2 ratio) were studied to understand the volcanic activity, as well as to investigate magma movement in both deep and shallow portions of the plumbing system, feeding the 2011 eruptive period. After the volcano deflation, accompanying the onset of the 2008–2009 eruption, a new recharging phase began in August 2008. This new volcanic cycle evolved from an initial recharge phase of the intermediate‐shallower plumbing system and inflation, followed by (i) accelerated displacement in the volcano's eastern flank since April 2009 and (ii) renewal of summit volcanic activity during the second half of 2010, culminating in 2011 in a cyclic eruptive behavior with 18 lava fountains from New Southeast Crater (NSEC). Furthermore, supported by the geochemical data, the inversion of ground deformation GPS data and the locations of the tremor sources are used here to constrain both the area and the depth range of magma degassing, allowing reconstructing the intermediate and shallow storage zones feeding the 2011 cyclic fountaining NSEC activity.
Reply to the discussion by Conti R., De Sanctis L. and Viggiani G.M.B. on ‘Influence of diaphragm wall installation on the numerical analysis of deep excavation’ by Burlon S., Mroueh H. & Shahrour I.
Authors: Burlon S. , Mroueh H. , Shahrour I. 
Published: June 2013

SUMMARYThe authors thank the discussers R.Conti, L.De Sanctis and G.M.B.Viggiani for their interest to the paper entitled ‘Influence of diaphragm wall installation on the numerical analysis of deep excavation’ and for providing the opportunity to submit additional information to clarify some issues. The authors broadly agree with the comments which deal with three main aspects of the paper: presence of water and type of analysis, constitutive modelling and numerical strategies.The present reply addresses some additional issues that the discussers find not clear on the original paper submitted by the writers. Copyright © 2013 John Wiley & Sons, Ltd.
Placing Transnational Migrants through Comparative Research: British Migrant Belonging in Five GCC Cities
Authors: Walsh Katie 
Published: June 2013

ABSTRACTThere is an emerging body of work analysing the significance of contemporary British migration flows and practices, much of which has consisted of single‐site, in‐depth ethnographies in particular (global) cities. As a result, attention has been directed towards the diversity evident within British migrant ‘communities’, and these studies have tended to emphasise similarities across space and continuities over time in the reproduction of British migrant belonging. In this paper, I assert the importance of comparative analysis of transnational migration in multiple sites to examine the significance of context in the making of migrant belonging. Drawing on preliminary fieldwork from five cities in the Gulf Cooperation Council states of the Persian Gulf, I provide evidence of the place‐specific heterogeneity that has arisen in the discourses of migrant belonging among British transnational migrants. The analysis focuses on three contextual factors that matter most among these particular migrants in these specific cities: firstly, the ratio of migrants to nationals; secondly, the migration history; and, thirdly, the speed and extent of urban transformation. The findings suggest that comparative research is vital in our efforts to understand transnational migrant belonging and that it can be a particularly useful methodological tool in elucidating the emplacement of transnational migrants. Copyright © 2013 John Wiley & Sons, Ltd.
Terahertz excitations of lambda systems in a semiconductor microcavity
Authors: Klettke A. C. , Kira M. , Koch S. W. , Tomaino J. L. , Jameson A. D. , Lee Y.‐S. , Khitrova G. , Gibbs H. M. 
Published: June 2013

AbstractRecent experiment‐theory investigations have demonstrated that the 2p‐exciton state and the polariton resonances of a semiconductor quantum‐well (QW) microcavity form a lambda (Λ) system where a terahertz (THz) field can selectively couple to either of the transitionallowed arms. However, semiconductors are open systems because seemingly isolated states are coupled to the continuum of states, either directly or via Coulomb or phonon scattering.A systematic theory is presented to treat these effects in a Λ system and in a two‐level system (TLS) described by the 1s‐to‐2p exciton transition in a semiconductor QW, without the microcavity. Excitonic occupations of polarization are analyzed as function of THz‐field frequency and intensity with (Λ system) and without (TLS) cavity. Even though the existence of Λ and TLS resonances is verified, significant deviations are observed at higher THz intensities, as higher ionized exciton states are generated via multi‐THz‐photon absorption.
Reliability Prediction Based on Variation Mode and Effect Analysis
Authors: Pavasson Jonas , Cronholm Kent , Strand Henrik , Karlberg Magnus 
Published: June 2013

The possibility of predicting the reliability of hardware for both components and systems is important in engineering design. Today, there are several methods for predicting the reliability of hardware systems and for identifying the causes of failure and failure modes, for example, fault tree analysis and failure mode and effect analysis.Many failures are caused by variations resulting in a substantial effect on safety or functional requirements. To identify, to assess and to manage unwanted sources of variation, a method called probabilistic variation mode and effect analysis (VMEA) has been developed. With a prescribed reliability, VMEA can be used to derive safety factors in different applications. However, there are few reports on how to derive the reliability based on probabilistic VMEA, especially for transmission clutch shafts.Hence, the objective of this article was to show how to derive system reliability based on probabilistic VMEA. In particular, wheel loader automatic transmission clutch shaft reliability is investigated to show how different sources of variation affect reliability.In this article, a new method for predicting system reliability based on probabilistic VMEA is proposed. The method is further verified by a case study on a clutch shaft. It is shown that the reliability of the clutch shaft was close to 1.0 and that the most significant variation contribution was due to mean radius of the friction surface and friction of the disc. Copyright © 2012 John Wiley & Sons, Ltd.
Microstructure of metallic copper nanoparticles/metallic disc interface in metal–metal bonding using them
Authors: Kobayashi Yoshio , Shirochi Tsukasa , Maeda Takafumi , Yasuda Yusuke , Morita Toshiaki 
Published: June 2013

AbstractThis paper describes a metal–metal bonding technique using metallic Cu nanoparticles prepared in aqueous solution. A colloid solution of metallic Cu particles with a size of 54 ± 15 nm was prepared by reducing Cu2+ (0.01 M (CH3COO)2Cu) with hydrazine (0.6 M) in the presence of stabilizers (5 × 10−4 M citric acid and 5 × 10−3 M cetyltrimethylammonium bromide) in water at room temperature in air. Discs made of metallic materials (Cu, Ni/Cu, or Ag/Ni/Cu) were successfully bonded under annealing at 400 °C and pressurizing at 1.2 MPa for 5 min in H2 gas with help of the metallic Cu particle powder. Shear strength required for separating the bonded discs was 27.9 ± 3.9 for Cu discs, 28.1 ± 4.1 for Ni/Cu discs, and 13.8 ± 2.6 MPa for Ag/Ni/Cu discs. Epitaxial crystal growth promotes on the discs with a good matching for the lattice constants between metallic nanoparticles and metallic disc surfaces, which leads to strong bonding. Copyright © 2013 John Wiley & Sons, Ltd.
Color Generation and Refractive Index Sensing Using Diffraction from 2D Silicon Nanowire Arrays
Authors: Walia Jaspreet , Dhindsa Navneet , Khorasaninejad Mohammadreza , Saini Simarjeet Singh 
Published: June 2013

AbstractTunable structural color generation from vertical silicon nanowires arranged in different square lattices is demonstrated. The generated colors are adjustable using well‐defined Bragg diffraction theory, and only depend on the lattice spacing and angles of incidence. Vivid colors spanning from bright red to blue are easily achieved. In keeping with this, a single square lattice of silicon nanowires is also able to produce different colors spanning the entire visible range. It is also shown that the 2D gratings also have a third grating direction when rotated 45 degrees. These simple and elegant solutions to color generation from silicon are used to demonstrate a cost‐effective refractive index sensor. The sensor works by measuring color changes resulting from changes in the refractive index of the medium surrounding the nanowires using a trichromatic RGB decomposition. Moreover, the sensor produces linear responses in the trichromatic decomposition values versus the surrounding medium index. An index resolution of 10−4 is achieved by performing basic image processing on the collected images, without the need for a laser or a spectrometer. Spectral analysis enables an increase in the index resolution of the sensor to a value of 10−6, with a sensitivity of 400 nm/RIU.
Optimization of Blast Furnace Productivity Coupled with CO2 Emissions Reduction
Authors: Cavaliere Pasquale , Perrone Angelo 
Published: June 2013

AbstractBlast furnace represents the dominant hot metal making production process worldwide and one of the main energy consuming processes. Modern research in the field focuses on the increase in plant productivity through energy saving and on the reduction of greenhouse gas emissions compatible with legal limits. Productivity is governed mainly by relevant input parameters such as materials rates, materials properties, and operating conditions. All the dominant input parameters and their variations have been analyzed in the present study and they have been optimized in order to increase plant productivity and reduce the greenhouse gas emissions. The raw materials quality analyses was largely taken into account especially with regard to sinter and coke quality. The reducibility of raw materials was demonstrated to largely influence plant efficiency. The study suggests new solutions in all processing parameters in order to improve plant productivity and to reduce the dangerous emissions.
The Development of Progress Plans Using a Performance‐Based Expert Judgment Model to Assess Technical Performance and Risk
Authors: Eggstaff Justin W. , Mazzuchi Thomas A. , Sarkani Shahram 
Published: June 2013

AbstractSystems engineers are routinely tasked with facilitating the delicate balance between cost, schedule, and technical performance in acquisition programs that are continuously subjected to various outside influences. While there are several quantitative methods to estimate acquisition program cost and schedule performance as well as identify their risks (e.g., Earned Value Management), the estimation of technical performance and technical risk is generally heuristic in nature. In order to monitor the progress of thetechnicalaspects of an acquisition program, the systems engineering discipline utilizes the process of tracking Technical Measures to gain insight into the design and development, to assess risks and issues, and to evaluate the likelihood of realizing objectives. However, with the diversity of so many technical programs, the estimation and risk analysis of technical performance in technology acquisition programs rely on the opinions of experts because the identification and application of relevant quantitative data for constructive modeling is not practical. The Expert‐weighted Technical Risk Index methodology proposed in this article introduces a well‐established method for mathematically combining expert judgment into the realm of systems engineering to develop predictive progress plans for technical performance estimation and risk analysis. © 2013 Wiley Periodicals, Inc. Syst Eng 17