bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reflexive account of unintended outcomes from spiritual care qualitative research
Authors: Narayanasamy Aru 
Published: May 2015

This paper presents a discussion of the reflexive accounts of research experience of the author when conducting data collection and analysis of an investigation into spirituality and culture in nurse education. Aims To offer insights into the unintended outcomes of research and personal transformation that may occur as a consequence of the research. Background Whilst extensive qualitative research prevails in nursing and nurse education, with some making a significant impact upon the practice and epistemology of nursing, reflexive accounts of unintended outcomes of research are rather scanty in the literature. Data Sources This paper draws on the reflective diary and field notes maintained by the researcher throughout the trajectory of the research involving a series of studies into spiritual care in nurse education. Discussion Reflective frameworks offer opportunities for honest reflexive accounts which may be quite revealing. The paper illuminates some salient features of unintended outcomes of the research involving participants who shared narratives of coping mechanisms using spiritual resources as they faced critical junctures such as illness in their lives. Conclusion The encounters between the researcher and the participants could lead to transformation and growth for both. Implications for practice Reflexive accounts of unintended outcomes should be integral to the qualitative research process and they could be transformative for both the researcher and the participants. The reflections on the unintended outcomes may provide valuable insights into patients’ experiences in order to produce a more comprehensive understanding of the phenomena being investigated. Summary statement What is already known about this topic Qualitative research produces rich and dense data impacting nursing. Qualitative research contributes to the epistemology of nursing. Reflexive accounts shed valuable insights about the qualitative research process. What this paper adds A structured approach to reflexive accounts may produce some interesting insights into the research process related to spirituality studies addressed in this paper. Unintended outcomes of spirituality research could be identified and theorised as integral to the whole research. Researchers need to invest time and attention into the unintended outcomes of research as they could be transformative for both the researcher and participants. Implications for practice and/or policy Reflexive accounts and unintended outcomes of research could be valuable for the researchers and participants’ transformation and growth. Further theories may evolve from unintended outcomes of research adding further insights into the unpredictable dimensions of humanity.
Effect of volar angulation of extra-articular distal radius fractures on distal radioulnar joint stability: a biomechanical study
Authors: Bessho Y. , Nakamura T. , Nagura T. , Nishiwaki M. , Sato K. , Toyama Y. 
Published: May 2015

The relationship between increased volar tilt of the distal radius and distal radioulnar joint stability was examined. Distal radioulnar joint stiffness was recorded at 10° intervals from 10° dorsal angulation to 20° of volar angulation from the anatomical position of the radius. Tests were performed with the intact radioulnar ligament and repeated after partial and then complete sectioning of the radioulnar ligament at the ulnar fovea. With the intact radioulnar ligament, distal radioulnar joint stiffness increased significantly at 10° and 20° of volar angulation. Partial sectioning of the radioulnar ligament resulted in an approximate 10% decrease of distal radioulnar joint stiffness compared with the intact state, but distal radioulnar joint stiffness still increased significantly with greater volar tilt. Complete sectioning of the radioulnar ligament significantly decreased distal radioulnar joint stiffness, and increasing the volar tilt did not result in increased distal radioulnar joint stiffness. These results suggest that volar angulation deformities of the distal radius should be corrected to 10° of volar tilt when the triangular fibrocartilage complex is intact. Level of Evidence: N/A
Calcaneal Insufficiency Fracture Secondary to Celiac Disease–Induced Osteomalacia
Authors: Kose Ozkan , Kilicaslan Omer Faruk , Ozyurek Selahattin , Ince Ahmet 
Published: May 2015

Plantar fasciitis is a common cause of plantar heel pain; however, a broad spectrum of disorders may also present with plantar heel pain. A detailed history, physical examination, laboratory testing, and imaging studies may be necessary to reach an accurate diagnosis. Herein, the clinical presentation of a 33-year-old woman with calcaneal insufficiency fracture secondary to celiac disease–induced osteomalacia is presented, and its diagnosis and treatment are discussed. Calcaneal insufficiency fractures should be kept in mind in a patient with celiac disease that presents with heel pain. Level of Evidence: Therapeutic, Level IV: Case study
Haploidentical vs identical-sibling transplant for AML in remission: a multicenter, prospective study
Authors: Wang Yu , Liu Qi-Fa , Xu Lan-Ping , Liu Kai-Yan , Zhang Xiao-Hui , Ma Xiao , Fan Zhi-Ping , Wu De-Pei , Huang Xiao-Jun 
Published: May 2015

Key PointsHaploidentical transplant achieves outcomes similar to those of identical-sibling transplant for AML patients in first remission. Haploidentical transplant is a valid postremission treatment of intermediate- or high-risk AML patients lacking an identical donor.
Atrazine adsorption removal with nylon6/polypyrrole core-shell nanofibers mat: possible mechanism and characteristics
Authors: Yang Bi-Yi , Cao Yang , Qi Fei-Fei , Li Xiao-Qing , Xu Qian 
Published: May 2015

Abstract
A functionalized nylon6/polypyrrole core-shell nanofibers mat (PA6/PPy NFM) was prepared via situ polymerization on nylon6 electrospun nanofibers mat (PA6 NFM) template and used as an adsorbent to remove atrazine from aqueous solutions. The core-shell structure of PA6/PPy NFM can be clearly proved under scanning electron microscope (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The effects of initial solution pH and ionic strength, as well as the comparison of the adsorption capacity of functionalized (PA6/PPy NFM) and non-functionalized (PA6 NFM) adsorbent, were examined to reveal the possible adsorption mechanism. The results indicated that π-π interaction and electrostatic interaction should play a key role in the adsorption process. The kinetics and thermodynamics studies also further elucidated the detailed adsorption characteristics of atrazine removal by PA6/PPy NFM. The adsorption of atrazine could be well described by the pseudo-second-order equation. The adsorption equilibrium data was well fitted with the Freundlich isotherm model with a maximum adsorption capacity value of 14.8 mg/g. In addition, the increase of adsorption rate caused by a temperature increase could be felicitously explained by the endothermic reaction. The desorption results showed that the adsorption capacity remained almost unchanged after six adsorption/desorption cycles. These results suggest that PA6/PPy NFM could be employed as an efficient adsorbent for removing atrazine from contaminated water sources.
Fast and scalable inference of multi-sample cancer lineages
Authors: Popic Victoria , Salari Raheleh , Hajirasouliha Iman , Kashef-Haghighi Dorna , West Robert B , Batzoglou Serafim 
Published: May 2015

AbstractSomatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny reconstruction. We present LICHeE (Lineage Inference for Cancer Heterogeneity and Evolution), a novel method that automates the phylogenetic inference of cancer progression from multiple somatic samples. LICHeE uses variant allele frequencies of somatic single nucleotide variants obtained by deep sequencing to reconstruct multi-sample cell lineage trees and infer the subclonal composition of the samples. LICHeE is open source and available at http://viq854.github.io/lichee.
The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver
Authors: Lu Lizhi , Chen Yan , Wang Zhuo , Li Xiaofeng , Chen Weihu , Tao Zhengrong , Shen Junda , Tian Yong , Wang Deqian , Li Guoqin , Chen Li , Chen Fang , Fang Dongming , Yu Lili , Sun Yudong , Ma Yong , Li Jinjun , Wang Jun 
Published: May 2015

Abstract
Background
Geese were domesticated over 6,000 years ago, making them one of the first domesticated poultry. Geese are capable of rapid growth, disease resistance, and high liver lipid storage capacity, and can be easily fed coarse fodder. Here, we sequence and analyze the whole-genome sequence of an economically important goose breed in China and compare it with that of terrestrial bird species.

Results
A draft sequence of the whole-goose genome was obtained by shotgun sequencing, and 16,150 protein-coding genes were predicted. Comparative genomics indicate that significant differences occur between the goose genome and that of other terrestrial bird species, particularly regarding major histocompatibility complex, Myxovirus resistance, Retinoic acid-inducible gene I, and other genes related to disease resistance in geese. In addition, analysis of transcriptome data further reveals a potential molecular mechanism involved in the susceptibility of geese to fatty liver disease and its associated symptoms, including high levels of unsaturated fatty acids and low levels of cholesterol. The results of this study show that deletion of the goose lep gene might be the result of positive selection, thus allowing the liver to adopt energy storage mechanisms for long-distance migration.

Conclusions
This is the first report describing the complete goose genome sequence and contributes to genomic resources available for studying aquatic birds. The findings in this study are useful not only for genetic breeding programs, but also for studying lipid metabolism disorders.
Large-scale analysis of the evolutionary histories of phosphorylation motifs in the human genome
Authors: Yoshizaki Hisayoshi , Okuda Shujiro 
Published: May 2015

Abstract

Background
Protein phosphorylation is a post-translational modification that is essential for a wide range of eukaryotic physiological processes, such as transcription, cytoskeletal regulation, cell metabolism, and signal transduction. Although more than 200,000 phosphorylation sites have been reported in the human genome, the physiological roles of most remain unknown. In this study, we provide some useful datasets for the assessment of functional phosphorylation signaling using a comparative genome analysis of phosphorylation motifs.

Findings
We described the evolutionary patterns of conservation of these and comparative genomic data for 93,101 phosphosites and 1,003,756 potential phosphosites in human phosphomotifs, using 178 phosphomotifs identified in a previous study that occupied 69% of known phosphosites in public databases. Comparative genomic analyses were performed using genomes from nine species from yeast to humans. Here we provide an overview of the evolutionary patterns of phosphomotif acquisition and indicate the dependence on motif structures. Using the data from our previous study, we describe the interaction networks of phosphoproteins, identify the kinase substrates associated with phosphoproteins, and perform gene ontology enrichment analyses. In addition, we show how this dataset can help to elucidate the function of phosphomotifs.

Conclusions
Our characterizations of motif structures and assessments of evolutionary conservation of phosphosites reveal physiological roles of unreported phosphosites. Thus, interactions between protein groups that share motifs are likely to be helpful for inferring kinase-substrate interaction networks. Our computational methods can be used to elucidate the relationships between phosphorylation signaling and cellular functions.
Marine organisms as source of bioactive molecules applied in restoration projects
Authors: Barresi Giovanna , Di Carlo Enza , Trapani Maria Rosa , Parisi Maria Giovanna , Chille Chiara , Mule Maria Francesca , Cammarata Matteo , Palla Franco 
Published: May 2015

Abstract
In recent decades research in the conservation and restoration field has provided sustainable alternatives to traditional procedures for cleaning or controlling the microbial colonization of works of art. In the present study, for the first time novel bioactive molecules extracted from marine invertebrate organisms (Anthozoa) were tested instead of chemical compounds for removing protein layers or as a biocide for controlling fungal or bacterial colonization. In particular, Bioactive Molecules with Protease activity (BMP), acting in a temperature range of 4- 30°C, were tested for the hydrolysis of protein layers on laboratory specimens. The cleaning protocol provides a selective procedure to avoid damage to the original materials constituting the heritage object.
Concurrently, enzymatic cleaning was also performed using commercial Protease from Aspergillus sojae (Type XIX), in order to compare their hydrolytic activities. Bioactive Molecules with Antimicrobial activity (BMA1, BMA2) were tested to control bacterial (Bacillus, Micrococcus) or fungal (Aspergillus, Penicillium) growth, previously isolated from colonized canvas samples and characterized by an integrated approach based on in vitro culture, microscopy and molecular investigations. These molecules were tested to define the Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal/ Fungicidal Concentration (MBC/MFC). Specifically, BMAs were used to control fungal growth during the relining of the painting (laboratory specimens), carried out using a canvas support, and glue paste as binder.
In our hypothesis, these molecules provide an important contribution to the development of innovative protocols for biocleaning or microbial growth control, based on fast and easy application, operator friendly and environmentally sustainable molecules.
Long-Term Follow-Up of a Community Assignment, One-Time Endoscopic Screening Study of Esophageal Cancer in China
Authors: Wei Wen-Qiang , Chen Zhi-Feng , He Yu-Tong , Feng Hao , Hou Jun , Lin Dong-Mei , Li Xin-Qing , Guo Cui-Lan , Li Shao-Sen , Wang Guo-Qing , Dong Zhi-Wei , Abnet Christian C. , Qiao You-Lin 
Published: May 2015

Purpose There are no global screening recommendations for esophageal squamous cell carcinoma (ESCC). Endoscopic screening has been investigated in areas of high incidence in China since the 1970s. This study aimed to evaluate whether an endoscopic screening and intervention program could reduce mortality caused by ESCC. Methods Residents age 40 to 69 years were recruited from communities with high rates of ESCC. Fourteen villages were selected as the intervention communities. Ten villages not geographically adjacent to intervention villages were selected for comparison. Participants in the intervention group were screened once by endoscopy with Lugol's iodine staining, and those with dysplasia or occult cancer were treated. All intervention participants and a sample consisting of one tenth of the control group completed questionnaires. We compared cumulative ESCC incidence and mortality between the two groups. Results Three thousand three hundred nineteen volunteers (48.62%) from an eligible population of 6,827 were screened in the intervention group. Seven hundred ninety-seven volunteers from an eligible population of 6,200 in the control group were interviewed. Six hundred fifty-two incident and 542 fatal ESCCs were identified during the 10-year follow-up. A reduction in cumulative mortality in the intervention group versus the control group was apparent (3.35% v 5.05%, respectively; P < .001). Furthermore, the intervention group had a significantly lower cumulative incidence of ESCC versus the control group (4.17% v 5.92%, respectively; P < .001). Conclusion We showed that endoscopic screening and intervention significantly reduced mortality caused by esophageal cancer. Detection and treatment of preneoplastic lesions also led to a reduction in the incidence of this highly fatal cancer.
Revised International Pediatric Non-Hodgkin Lymphoma Staging System
Authors: Rosolen Angelo , Perkins Sherrie L. , Pinkerton C. Ross , Guillerman R. Paul , Sandlund John T. , Patte Catherine , Reiter Alfred , Cairo Mitchell S. 
Published: May 2015

PurposeTreatment and prognosis of pediatric non-Hodgkin lymphoma (NHL) have improved dramatically in the last 30 years. However, the St Jude NHL staging classification for pediatric NHL was developed more than 35 years ago. The most recent Lugano lymphoma staging classification focused on adult lymphoma. Furthermore, major limitations of the current pediatric NHL staging classification include lack of consideration of new distinct pediatric NHL histologic entities; absence of recognition of frequent skin, bone, kidney, ovarian, and other organ involvement; and lack of newer precise methods to detect bone marrow and CNS involvement, minimal disease quantification, and highly sensitive imaging technologies.MethodsAn international multidisciplinary expert panel convened in Frankfurt, Germany, in 2009 at the Third International Childhood, Adolescent and Young Adult NHL Symposium to develop a revised international pediatric NHL staging system (IPNHLSS), addressing limitations of the current pediatric NHL staging system and creating a revised classification. Evidence-based disease distribution and behavior were reviewed from multiple pediatric cooperative group NHL studies.ResultsA revised IPNHLSS was developed incorporating new histologic entities, extranodal dissemination, improved diagnostic methods, and advanced imaging technology.ConclusionThis revised IPNHLSS will facilitate more precise staging for children and adolescents with NHL and facilitate comparisons of efficacy across different treatment strategies, various institutions, multicenter trials, and cooperative groups by allowing for reproducible pediatric-based staging at diagnosis and relapse.
Circulating Progenitor Cell Count Predicts Microvascular Outcomes in Type 2 Diabetic Patients
Authors: Rigato Mauro , Bittante Cristina , Albiero Mattia , Avogaro Angelo , Fadini Gian Paolo 
Published: May 2015

Context:
Diabetes reduces the levels of circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs), which promote vascular repair and are inversely correlated with cardiovascular risk.

Objective:
The objective of the study was to test whether CPC/EPC levels predict onset/progression of microangiopathy in a cohort of type 2 diabetic (T2D) patients.

Design:
This was a pseudoprospective study with a 3.9-year follow-up.

Setting:
The study was conducted at a tertial referral diabetes outpatient clinic.

Patients:
A total of 187 T2D patients having a baseline determination of CPCs/EPCs participated in the study.

Intervention:
Baseline data on demographics, anthropometrics, concomitant risk factors, diabetic complications, and medications were collected.

Main Outcome Measure:
Onset or progression of microangiopathy was assessed at follow-up compared with baseline.

Results:
New onset or progression of microalbuminuria, chronic kidney disease, retinopathy, and neuropathy occurred in 70 patients (9.5%/y). After controlling the false discovery rate, baseline CD34+ CPCs and EPCs were significantly lower in patients with onset/progression of microalbuminuria and any microangiopathy. Patients with baseline CD34+ CPC or CD133+/kinase insert domain-containing receptor+/EPC levels below the median were more likely to experience worsening microangiopathy than those with high cell levels. Independently from confounders, including age, sex, glycated hemoglobin, and diabetes duration, CD34+ cells predicted onset/progression of microalbuminuria, retinopathy, and any microangiopathy in false discovery rate-adjusted analyses. A low CD34+ cell count limited the beneficial effects of renin-angiotensin system blockers on microalbuminuria progression.

Conclusions:
Levels of circulating (endothelial) progenitor cells predict microvascular outcomes in T2D. Together with previous studies showing an association with cardiovascular events, these data indicate that CPCs/EPCs represent biomarkers of the global complication burden in diabetes.
Forest Products Industry Size and Economic Multipliers in the US South
Authors: Dahal Ram P. , Henderson James E. , Munn Ian A. 
Published: May 2015

Abstract
The forest products industry (FPI) is an important component of local, state, regional, and national economies. Thus, assessing its economic contribution can provide valuable information to policymakers and forestry interests. IMPLAN, an input–output model, was used to assess the economic contribution of the FPI in 13 US southern states for the year 2009, individually as well as regionally, and to compare it with that in 2001, the last comprehensive study of the industry in the South. Two aspects of economic contribution, direct impacts and associated economic multipliers, were estimated for three primary FPI sectors (lumber and wood products, paper and allied products, and wood furniture). The FPI in the South employed 470,000 individuals and generated $133 billion of gross output. The industry's employment decreased by 33.9 percent while gross output increased by 15.1 percent between 2001 and 2009. Study findings reveal that the FPI reduced employment relative to total industry output to maintain production during the recession period providing evidence of capital substitution for labor. This implies that despite the disproportionate impacts of the great recession of the 2000s, the industry is still an important component of the South's economy. Thus, this article will provide insights about how the economic contribution of the FPI changes over time. In addition, results of this study will be helpful in identifying important industry shifts and help formulate policies and regulations to support the FPI.
Durable bonds at the adhesive/dentin interface:an impossible mission or simply a moving target?
Authors: Spencer Paulette , Ye Qiang , Park Jonggu , Misra Anil , Bohaty Brenda S. , Singh Viraj , Parthasarathy Ranga , Sene Fabio , Gonçalves Sergio , Laurence Jennifer 
Published: May 2015

Composite restorations have higher failure rates, more recurrent caries and increased frequency of replacement as compared to dental amalgam. Penetration of bacterial enzymes, oral fluids, and bacteria into the crevices between the tooth and composite undermines the restoration and leads to recurrent decay and failure. The gingival margin of composite restorations is particularly vulnerable to decay and at this margin, the adhesive and its seal to dentin provides the primary barrier between the prepared tooth and the environment. The intent of this article is to examine physico-chemical factors that affect the integrity and durability of the adhesive/dentin interfacial bond; and to explore how these factors act synergistically with mechanical forces to undermine the composite restoration. The article will examine the various avenues that have been pursued to address these problems and it will explore how alterations in material chemistry could address the detrimental impact of physico-chemical stresses on the bond formed at the adhesive/dentin interface.