bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential Utility of High-Resolution Ensemble Sensitivity Analysis for Observation Placement during Weak Flow in Complex Terrain
Authors: Wile Sean M. , Hacker Joshua P. , Chilcoat Kenneth H. 
Published: May 2015

AbstractExpansion in the availability of relocatable near-surface atmospheric observing sensors introduces the question of where placement maximizes gain in forecast accuracy. As one possible method of addressing observation placement, the performance of ensemble sensitivity analysis (ESA) is examined for high-resolution (Δx = 4 km) predictions in complex terrain and during weak flow. ESA can be inaccurate when the underlying assumptions of linear dynamics (and Gaussian statistics) are violated, or when the sensitivity cannot be robustly sampled. A case study of a fog event at Salt Lake City International Airport (KSLC) in Utah provides a useful basis for examining these issues, with the additional influence of complex terrain. A realistic upper-air observing network is used in perfect-model ensemble data assimilation experiments, providing the statistics for ESA. Results show that water vapor mixing ratios over KSLC are sensitive to potential temperature on the first model layer tens of kilometers away, 6 h prior to verification and prior to the onset of fog. Potential temperatures indicate inversion strength in the Salt Lake basin; the ESA predicts southerly flow and strengthened inversions will increase water vapor over KSLC. Linearity tests show that the nonlinear response is about twice the expected response. Experiments with smaller ensembles show that qualitatively similar conclusions about the sensitivity pattern can be reached with ensembles as small as 48 members, but smaller ensembles do not produce accurate sensitivity estimates. Taken together, the results motivate a closer look at the fundamental characteristics of ESA when dynamics (and therefore correlations) are weak.
Maintaining occupation-based practice in Australian mental health practice: A critical stance
Authors: Ashby Samantha , Gray Mel , Ryan Susan , James Carole 
Published: May 2015

Introduction This paper explores the way dominant discourses, and their associated practice knowledge dimensions, shape personal paradigms and occupation-based practice in mental health workplaces. Method Narrative inquiry methods and narrative thematic analysis was used to explore the career stories of nine occupational therapists who had worked in mental health practice for more than five years. Findings The main narrative themes to emerge were (i) living with the biomedical practice knowledge discourse, (ii) living with the psychological practice knowledge discourse and (iii) reflection as a strategy for maintaining occupation-based practice. These discourses created the need to reflect on practice and adopt strategies to avoid the marginalisation of occupational perspectives and occupation-based practice. The strategies used to cope with these discourses varied from acceptance and embracing of other discourses to resistance and rejection. Conclusion This paper demonstrates that in some mental health workplaces there is a danger that occupational perspectives and occupation-based practice can become marginalised. Making visible the different discourses in mental health practice allows occupational therapists to analyse, better understand, and live with the tensions in their professional lives. This requires professional support strategies to be in place to maintain occupation-based practices and retain practitioners in the workforce.
Heavy Slow Resistance Versus Eccentric Training as Treatment for Achilles Tendinopathy
Authors: Beyer Rikke , Kongsgaard Mads , Hougs Kjær Birgitte , Øhlenschlæger Tommy , Kjær Michael , Magnusson S. Peter 
Published: May 2015

Background: Previous studies have shown that eccentric training has a positive effect on Achilles tendinopathy, but few randomized controlled trials have compared it with other loading-based treatment regimens. Purpose: To evaluate the effectiveness of eccentric training (ECC) and heavy slow resistance training (HSR) among patients with midportion Achilles tendinopathy. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 58 patients with chronic (>3 months) midportion Achilles tendinopathy were randomized to ECC or HSR for 12 weeks. Function and symptoms (Victorian Institute of Sports Assessment–Achilles), tendon pain during activity (visual analog scale), tendon swelling, tendon neovascularization, and treatment satisfaction were assessed at 0 and 12 weeks and at the 52-week follow-up. Analyses were performed on an intention-to-treat basis. Results: Both groups showed significant ( P < .0001) improvements in Victorian Institute of Sports Assessment–Achilles and visual analog scale from 0 to 12 weeks, and these improvements were maintained at the 52-week follow-up. Concomitant with the clinical improvement, there was a significant reduction in tendon thickness and neovascularization. None of these robust clinical and structural improvements differed between the ECC and HSR groups. However, patient satisfaction tended to be greater after 12 weeks with HSR (100%) than with ECC (80%; P = .052) but not after 52 weeks (HSR, 96%; ECC, 76%; P = .10), and the mean training session compliance rate was 78% in the ECC group and 92% in the HSR group, with a significant difference between groups ( P < .005). Conclusion: The results of this study show that both traditional ECC and HSR yield positive, equally good, lasting clinical results in patients with Achilles tendinopathy and that the latter tends to be associated with greater patient satisfaction after 12 weeks but not after 52 weeks.
Swiss Medical Board Mammography screening predictions for Switzerland: Importance of time-periods
Authors: de Koning HJ , Heijnsdijk EAM 
Published: May 2015

Objectives In 2013, the Swiss Medical Board (SMB) concluded that for three breast cancer screens over 13 years in Switzerland, cost-effectiveness was negative, with no additional benefits in quality-adjusted life-years gained. We compared these suggested predicted effects with other estimates. Methods We used an extensively validated model on the natural history of breast cancer in Switzerland, comparing a 13-year time frame, a life-time perspective, and a continuous screening programme, per 10,000 Swiss women. Both approaches used the Swedish randomized controlled trials for the theoretical effect. Results Over 13 years, both approaches yield comparable life-years gained (56 versus 67), but in expectation in 10,000 women’s lifetimes 444 life-years are gained, and in a continuous screening programme (instead of three screens) 839 years. The SMB estimate of 56 life-years gained is counterweighted by 57 negative quality of life adjusted years, primarily resulting from a 5% annual loss for 10% of women, being false-positive results. International literature is consistent with more than four times lower losses on false-positives. The estimate of overdiagnosed cases in the 13-year time frame was four times higher than in the long-term perspective. Conclusions By restricting life-years gained to a 13-year time frame the SMB prediction on benefits of mammography screening is unrealistically low. Predicting long-term harms and benefits, specifically tailored to observations, regarding the clinical situation before screening commences, and possible data during a screening programme, are crucial for women, professionals, and policymakers.
IgG4-associated orbital and ocular inflammation
Authors: Lee Cecilia S , Harocopos George J , Kraus Courtney L , Lee Aaron Y , Van Stavern Gregory P , Couch Steven M , Rao P Kumar 
Published: May 2015

Abstract

Background
IgG4-associated orbital and ocular inflammation is a relatively unknown entity characterized by sclerosing inflammation with infiltration of IgG4-positive plasma cells. Some so-called idiopathic inflammation syndromes are being re-classified as IgG4-associated inflammation with histopathologic evaluation.

Findings
We report three cases with differing manifestations of IgG4-associated ocular and orbital inflammation: a case of recurrent, treatment-refractory sclero-uveitis that was diagnosed as granulomatosis with polyangiitis with an IgG4-related component, a case of pachymeningitis with optic neuritis that resulted in permanent visual loss, and a case of orbital inflammatory pseudotumor. All three would have been incompletely diagnosed without thorough histopathologic evaluation (including immunohistochemistry).

Conclusions
IgG4-associated disease is an idiopathic, multi-organ inflammatory state that can manifest as chronic, relapsing, sclerosing inflammation in virtually any organ system. There is a wide range of presentations in ocular and orbital inflammation. Ophthalmologists should keep IgG4-associated inflammation in mind when examining chronic, sclerofibrosing inflammation with multi-system involvement. The histology of biopsy specimens is crucial in making the correct diagnosis. Timely assessment may lead to fewer diagnostic tests and more targeted therapy.
Control of IFN-γ production and regulatory function by the inducible nuclear protein IκB-ζ in T cells
Authors: MaruYama Takashi , Kobayashi Shuhei , Ogasawara Kouetsu , Yoshimura Akihiko , Chen WanJun , Muta Tatsushi 
Published: May 2015

Abstract
The transcriptional regulator IκB-ζ is important for the control of apoptosis in keratinocytes. Thus, IκB-ζ-deficient mice develop autoimmune diseases, such as Sjögren’s syndrome. However, T cells also play a pivotal role in Sjögren’s syndrome. To study the role of IκB-ζ in T cells, we generated T cell-specific, IκB-ζ-deficient mice. We observed increased numbers of peripheral effector/memory CD4+ cells and IFN-γ-producing CD4+ cells in 3-week-old mice. We found that IκB-ζ can be up-regulated by TGF-β1 in naϊve CD4+ T cells and that it negatively regulates IFN-γ expression. In addition, we generated Treg-specific, IκB-ζ deficient mice and found that IκB-ζ is dispensable for the plasticity and stability of Tregs. However, Tregs from T cell-specific, IκB-ζ-deficient mice have reduced immunoregulatory function. Thus, our data reveal a previously unappreciated role for IκB-ζ in IFN-γ production in T cells and the immunoregulatory function of Tregs.
Defining the functional states of Th17 cells
Authors: Lee Youjin , Kuchroo Vijay 
Published: May 2015

The molecular mechanisms governing T helper (Th) cell differentiation and function have revealed a complex network of transcriptional and protein regulators. Cytokines not only initiate the differentiation of CD4 Th cells into subsets but also influence the identity, plasticity and effector function of a T cell. Of the subsets, Th17 cells, named for producing interleukin 17 (IL-17) as their signature cytokine, secrete a cohort of other cytokines, including IL-22, IL-21, IL-10, IL-9, IFNγ, and GM-CSF. In recent years, Th17 cells have emerged as key players in host defense against both extracellular pathogens and fungal infections, but they have also been implicated as one of the main drivers in the pathogenesis of autoimmunity, likely mediated in part by the cytokines that they produce. Advances in high throughput genomic sequencing have revealed unexpected heterogeneity in Th17 cells and, as a consequence, may have tremendous impact on our understanding of their functional diversity. The assortment in gene expression may also identify different functional states of Th17 cells. This review aims to understand the interplay between the cytokine regulators that drive Th17 cell differentiation and functional states in Th17 cells.
Notes on the type designation of Magnolia odoratissima (Magnoliaceae)
Authors: Deng Yun-Fei , Xia Nian-He 
Published: May 2015

AbstractThe type of Magnolia odoratissima is reviewed. In the protologue, the type was indicated as Zhou Rengzhang 54 (IBSC), even though this specimen is in serious conflict with the original description, which nicely matches another specimen, Zhou Rengzhang 58 (ISBC). Chen and Zeng maintained that the name M. odoratissima must be treated as a heterotypic synonym of Parakmeria yunnanensis, since this is the species represented by Zhou Rengzhang 54, and they proposed the name M. kwangnanensis for the species represented by Zhou Rengzhang 58. It is concluded here that Chen & Zeng's position is based on an inappropriate interpretation of Art. 9.1 Note 1 of the ICN and ignores the ICN's allowance for the correction of obvious errors in type citation (Art. 9.1 Ex. 2). Therefore, the type of M. odoratissima is Zhou Rengzhang 58 and M. kwangnanensis is a superfluous and illegitimate renaming of M. odoratissima.
The Impacts of Advertising Assets and R&D Assets on Reducing Bankruptcy Risk
Authors: Jindal Niket , McAlister Leigh 
Published: May 2015

Research has shown that advertising assets and R&D (research and development) assets increase shareholder value. Although one might conclude that their impacts on bankruptcy risk are merely the inverse of their impacts on shareholder value, we argue otherwise and show that the differences hinge on the fact that shareholder value is a function of expected cash flows from all future periods, whereas bankruptcy risk is a function of expected cash flow from only the next period. We show that current market turbulence moderates the impacts of advertising assets and R&D assets on expected cash flow from the next period but not on expected cash flows from more distant future periods. Therefore, market turbulence moderates the impacts of advertising assets and R&D assets on bankruptcy risk but not shareholder value. Market stability increases the impact of advertising assets on reducing bankruptcy risk, whereas market turbulence increases the impact of R&D assets on reducing bankruptcy risk. Using a data set of more than 1,000 firms covering three decades, we find support for our hypotheses. Out-of-sample validation indicates that bankruptcy prediction performance improves when including marketing variables in addition to the usual financial predictors. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mksc.2015.0913 .
Perioperative hypothermia and surgical site infections part 1
Authors: Mann Alison 
Published: May 2015

Perioperative hypothermia has been identified as an infection risk factor in human literature, however, literature from veterinary counterparts is conflicting. Registered veterinary nurses (RVNs) should always strive to provide the gold standard of care to their patients including when under anaesthesia and in the operating theatre. This can include looking at available evidence for standards of care, in this instance how best to maintain normothermia during the perioperative period. Part one of this article introduces the concept of surgical site infections (SSIs) as well as exploring hypothermia in the perioperative phase and how this may occur. Available evidence is examined for perioperative hypothermia and its links to SSIs. The author compares literature from both humans and animals and highlights key points while critiquing available research. Part two of this article will explore ways of maintaining normothermia in the perioperative phase by looking at the effectiveness of various methods discussed in studies and concluding with recommendations for further study as well as recommendations for RVNs in practice.
Reviews
Authors: Levine Stephen K. , Lith Theresa Van , Tornabene Ladona , Vogelsang Lisa , Douek Deborah R. 
Published: May 2015

Abstract
Presence and Process in Expressive Arts Work – At the Edge of Wonder, Herbert Eberhart and Sally Atkins (2014) London and Philadelphia: Jessica Kingsley Publishers, 184 pp., ISBN: 9781849059572, p/bk, £17.99/$28.95
Ethics in Art Therapy: Challenging Topics for a Complex Modality, Lisa R. Furman (2013) London: Jessica Kingsley Publishers London and Philadelphia, 128 pp., ISBN: 9781849059381, p/bk, £17.99
Enhancing Lives through Arts & Health: 25th Anniversary Conference & Celebration 2014 Global Alliance for Arts & Health Conference, Houston, Texas, USA, 9–12 April 2014
5th Annual Healing Arts Coalition Conference: Growing up Autism, 21 November 2014
Read-aloud group Bibliotherapy for the elderly: An exploration of cognitive and social transformation
Authors: Genuis Katrina 
Published: May 2015

Abstract
There are increasing societal concerns regarding the lack of resources available to meet the multifaceted needs of the growing elderly population in the western world. In an effort to address the cognitive and social needs of this population, the author received guidance from the University of British Columbia’s Faculty of Medicine in initiating a novel form of Bibliotherapy, held weekly at a local respite-care centre. While conventional Bibliotherapy – the use of literature to promote well-being – involves private readings and reflection, the current Bibliotherapy programme involved meeting in a small group setting (from three to twelve individuals), reading aloud various types of literature (poetry, short stories, science articles, cultural fables, newspaper clips and jokes) and reflecting on the readings together. The reflection time included sharing of interpretations, discussing stimulated memories and considering relevant life issues and challenges. In observing this act of reflection, the author noted that otherwise isolated individuals discuss their feelings of loneliness and irrelevance, interact with a group, remember long-lost memories and consider stimulating topics. The dramatic success of this uniquely structured programme demonstrates that read-aloud group Bibliotherapy carried out within care centres for the elderly may have an impactful role in addressing the unmet cognitive and social needs of this population.
Moral responsibility is never a spectator sport: On young people and online gaming
Authors: Clancy Anne , Arvola Anne Karin , Gjærum Rikke Gürgens 
Published: May 2015

Abstract
Background: Massively Multiplayer Online Games create concerns for the health and well-being of young adults. The purpose of the article is to give a deeper insight into online game players’ ethical thinking and how playing online games affects their daily lives and relationships with others in the real world. Method: Data are collected from ten qualitative research interviews in Norway. The article contributes with two philosophical interpretations of the young people’s stories: the fundamental ethics of Emmanuel Levinas and Pragmatic Aesthetics. Findings: Online gaming can be a momentary aesthetic escape from reality, but players can become morally constrained when their behaviour affects those close to them. Constant conflict due to excessive gaming can cause them to retreat further into the game as an escape from real-world pressures. Conclusion: Moral responsibility is not only the young person’s concern. The diversity of moral concerns needs to be acknowledged.
New speakers on lost ground in the football stadium
Authors: Percio Alfonso Del 
Published: May 2015

AbstractFootball is a key site for local pride to be enacted by fans through the celebration of local dialects and local myths. At the same time, sport industries are currently undergoing major transformations and becoming global, professional and profit-oriented. Consequently, pride in a place is not solely the property of the given area or its inhabitants. Indeed, fandom is increasingly enacted by new groups who speak different languages and live in other places, and who thus cross borders to consume local fan practices and tokens of imagined local authenticity. Furthermore, football clubs are increasingly owned by multinational investors who employ international and multilingual football workers. Meanwhile, nostalgic adherents of so-called traditional football frequently interpret the emergence of these transnational actors as a corruption of this sport. The presence of such transnational actors raises questions regarding the challenges encountered by these new speakers when they produce and consume cultural resources that are widely perceived to be not only the commodities sold by the football industry but also tokens of local authenticity. Drawing on an ethnography conducted in the stadium of the FC Basel in Switzerland, I discuss the case of two transnational actors who are identified as new speakers of Basel’s local dialect and of standard German, both codes being specifically associated with being a legitimate fan or coach of FC Basel. In discussing the challenges faced by these new speakers during their encounters with FC Basel as a commercial product, I examine how these individuals have constructed their legitimacy as members of FC Basel’s imagined community and analyze how, why, and by whom this legitimacy is given or contested.
Second generation analysis of antinuclear antibody (ANA) by combination of screening and confirmatory testing
Authors: Scholz Juliane , Grossmann Kai , Knütter Ilka , Hiemann Rico , Sowa Mandy , Röber Nadja , Rödiger Stefan , Schierack Peter , Reinhold Dirk , Bogdanos Dimitrios P. , Meroni Pier Luigi , Radice Antonella , Conrad Karsten , Roggenbuck Dirk 
Published: May 2015

AbstractFor the serological diagnosis of systemic autoimmune rheumatic diseases, a two-tier approach starting with sensitive antinuclear antibody (ANA) detection by indirect immunofluorescence (IIF) on HEp-2 cells followed by characterization of positive findings with different immunoassays is recommended. To overcome drawbacks of this approach, we developed a novel technique allowing the combination of screening and simultaneous confirmatory testing. For the first time, this creates the basis for second generation ANA testing.ANA and autoantibodies (autoAbs) to double-stranded DNA (dsDNA), CENP-B, SS-A/Ro52, SS-A/Ro60, SS-B/La, RNP-Sm, Sm, and Scl-70 were determined by IIF and enzyme-linked immunosorbent assay (ELISA), respectively, and compared to simultaneous analysis thereof by second generation ANA analysis in patients with systemic lupus erythematosus (n=174), systemic sclerosis (n=103), Sjögren’s syndrome (n=46), rheumatoid arthritis (n=36), mixed and undetermined connective tissue diseases (n=13), myositis (n=21), infectious disease (n=21), autoimmune liver disease (n=93), inflammatory bowel disease (n=78), paraproteinemia (n=11), and blood donors (n=101).There was very good agreement of second generation ANA testing with classical one by IIF and ELISA regarding testing for ANA and autoAbs to dsDNA, CENP-B, SS-B, RNP-Sm, Scl-70, SS-A/Ro52, and SS-A/Ro60 (Cohen’s κ>0.8). The agreement for anti-Sm autoAb was good (κ=0.77). The differences of both approaches were not significant for autoAbs to SS-B/La, RNP-Sm, Scl-70, SS-A/Ro60, and SS-A/Ro52 (McNemar’s test, p>0.05, respectively).Second generation ANA testing can replace the two-tier analysis by combining IIF screening with multiplex confirmative testing. This addresses shortcomings of classical ANA analysis like false-negative ANA findings and lack of laboratory efficiency and standardization.