bluuebunny/crossref_metadata_2025_split huggingface dataset:
West Nile virus–specific immunoglobulin isotype responses in vaccinated and infected horses
Authors: Khatibzadeh Sarah M. , Gold Carvel B. , Keggan Alison E. , Perkins Gillian A. , Glaser Amy L , Dubovi Edward J. , Wagner Bettina 
Published: December 2014

Abstract
OBJECTIVE To compare antibody responses of horses naturally infected with West Nile virus (WNV) and those vaccinated against WNV, to identify whether vaccination interferes with the ability to diagnose WNV infection, and to determine the duration of antibody responses after vaccination.
SAMPLE Sera from horses naturally infected with WNV (n = 10) and adult WNV-naïve horses before and after vaccination with a live canarypox virus–vectored vaccine (7) or a killed virus vaccine (8).
PROCEDURES An established WNV IgM capture ELISA was used to measure IgM responses. Newly developed capture ELISAs were used to measure responses of 8 other WNV-specific immunoglobulin isotypes. A serum neutralization assay was used to determine anti-WNV antibody titers.
RESULTS WNV-specific IgM responses were typically detected in the sera of WNV-infected horses but not in sera of horses vaccinated against WNV. Natural infection with and vaccination against WNV induced an immunoglobulin response that was primarily composed of IgG1. West Nile virus–specific IgG1 was detected in the sera of most horses 14 days after vaccination. Serum anti-WNV IgG1 and neutralizing antibody responses induced by the killed-virus vaccines were higher and lasted longer than did those induced by the live canarypox virus–vectored vaccine.
CONCLUSIONS AND CLINICAL RELEVANCE On the basis of these findings, we recommend that horses be vaccinated against WNV annually near the beginning of mosquito season, that both IgM and IgG1 responses against WNV be measured to distinguish between natural infection and vaccination, and that a WNV IgG1 ELISA be used to monitor anti-WNV antibodies titers in vaccinated horses.
Insights into assembly of the macromolecular inflammasome complex
Authors: Monie Tom P. , Boyle Joseph P. 
Published: December 2014

AbstractDramatic advances in our understanding of the ultrastructure of the inflammasome and the molecular interactions involved in its assembly have recently been made. The adaptor protein ASC has been proposed to display prion-like activity that results in the formation of filamentous structures in the cell. These filamentouos structures can subsequently become inflammatory themselves if released into the extracellular space and then phagocytosed. Various groups have now utilised a variety of microscopy and structural approaches in order to visualise components of, and indeed the entire, inflammasome in both endogenous and overexpression systems. In this brief review we draw upon these new pieces of work to describe how our understanding of the global structure of the inflammasome has progressed in light of these new observations. In particular we begin by providing an initial perspective on the possible formation of small circular, wheel-like, oligomers resembling apoptosomes. We then address the current view that inflammasomes result from the formation of a much larger complex which may involve polymeric filaments. We discuss how these developments fit with recent theories of inflammatory signalling, what questions these advances raise, and propose key areas for further investigation.
Enterocutaneous fistula: a rare complication following total abdominal hysterectomy
Authors: Shakya Archana , Thapa Meena , Padhye Saraswati M 
Published: December 2014

Postoperative enterocutaneous fistula can occur after any gastrointestinal surgery. It is however uncommon following gynaecologic procedures. Although adjacent organ fistulae such as the rectovaginal and vesico-vaginal fistulae could be seen after hysterectomy, enterocutaneous fistulae are rarely encountered. We report a case of enterocutaneous fistula on twenty second post-operative day following total abdominal hysterectomy with bilateral salphingo-oopherectomywith partial omentectomy. The patient was managed conservatively which resulted in spontaneous closure of the fistula. DOI: http://dx.doi.org/10.3126/jkmc.v2i4.11791Journal of Kathmandu Medical CollegeVol. 2, No. 4, Issue 6, Oct.-Dec., 2013Page : 205-207
The Effect of Recombinant Human Growth Hormone with or without Rosiglitazone on Hepatic Fat Content in HIV-1-Infected Individuals: A Randomized Clinical Trial
Authors: Kotler Donald P , He Qing , Engelson Ellen S , Albu Jeanine B , Glesby Marshall J 
Published: December 2014

Background Hepatic fat is related to insulin resistance (IR) and visceral adipose tissue (VAT) in HIV+ and uninfected individuals. Growth hormone (GH) reduces VAT but increases IR. We evaluated the effects of recombinant human GH (rhGH) and rosiglitazone (Rosi) on hepatic fat in a substudy of a randomized controlled trial. Methods HIV+ subjects with abdominal obesity and IR (QUICKI≤0.33) were randomized to rhGH 3 mg daily, Rosi 4 mg twice daily, the combination or double placebo. Hepatic fat was measured by magnetic resonance spectroscopy, visceral fat by MRI and IR by frequently sampled intravenous glucose tolerance tests at baseline and week 12. Results 31 subjects were studied at both time points. Significant correlations between hepatic fat and VAT (r=0.41; P=0.02) and QUICKI (r=0.39; P<0.05) were seen at baseline. IR rose with rhGH but not Rosi. When rhGH treatment groups were combined, hepatic fat expressed as percentage change decreased significantly ( P<0.05) but did not change in Rosi ( P=0.71). There were no correlations between changes in hepatic fat and VAT ( P=0.4) or QUICKI ( P=0.6). In a substudy of 21 subjects, a trend was noticed between changes in hepatic fat and serum insulin-like growth factor-1 (IGF-1; P=0.09). Conclusions Hepatic fat correlates significantly with both VAT and IR, but changes in hepatic fat do not correlate with changes in VAT and glucose metabolism. Hepatic fat content is reduced by rhGH but Rosi has no effect. These results suggest an independent effect of GH or IGF-1 on hepatic fat. The study was registered at Clinicaltrials.gov (NCT00130286).
Le sociolinguistique comme contexte et le sémiotique comme construction, ou vice-versa : « Who's the a rtist ? »
Authors: Nicolaï Robert 
Published: December 2014

Je reviens ici sur la notion gumperzienne de contextualization cues (indices de contextualisation) et sur la dynamique entre signes « symboliques » et signes « indexicaux », essentielle pour l’émergence du sens et des formes, afin de la saisir dans son évidence et dans sa complexité. Après avoir reconnu l’importance de la focalisation sur les indexicaux dans les procès de mise en signification, je développe une autre argumentation en me focalisant non plus sur les signes indexicaux, mais sur les signes linguistiques. Un élargissement conceptuel est ainsi proposé pour questionner le langage en tant que dynamique (plutôt que la dynamique du langage) en y intégrant certaines récentes réflexions sur la construction du sémiotique (Nicolaï 2011). In fine , il s’agit d’œuvrer pour mieux rendre compte à la fois de la mise en signification en contexte de ce qui s’énonce et se manifeste, et de la construction du sens à travers la fabrication et/ou la transformation des formes. Double procès dont Gumperz a fortement contribué à développer le premier pan, et dont nous sommes inéluctablement partie prenante.
John J. Gumperz, un dialectologue anthropologue pour notre temps Entretien entre Jacky Simonin et Josiane Boutet
Authors: Simonin Jacky , Boutet Josiane 
Published: December 2014

Jacky Simonin a fait partie dans les années 1970 d’une équipe de recherche à l’université de Villetaneuse - Paris-13 qui s’est intéressée très tôt aux travaux de John J. Gumperz, et plus largement à la sociologie des interactions sociales et à la sociolinguistique nord-américaines. Jacky Simonin analyse ici comment il a reçu et fait travailler dans ses propres travaux les notions de la sociolinguistique interactionnelle interprétative de John Gumperz. Cet entretien est conduit par Josiane Boutet qui, bien qu’appartenant à la même génération des universitaires post-68, n’a pas connu le même parcours intellectuel. C’est donc un dialogue entre deux sociolinguistes et deux itinéraires dans un même champ disciplinaire.
Easily Accessible TADDOL‐Derived Bisphosphonite Ligands: Synthesis and Application in the Asymmetric Hydroformylation of Vinylarenes
Authors: Allmendinger Simon , Kinuta Hirotaka , Breit Bernhard 
Published: December 2014

AbstractThe synthesis of chiral bidentate bisphosphonite ligands based on the TADDOL motif from readily available starting materials has been developed. Taking advantage of the modular nature of the building blocks, a diverse ligand library has been prepared. Their catalytic potential has been evaluated in the asymmetric hydroformylation of styrene and derivatives. These catalysts showed high activity and provided the aldehydes in high enantiomeric purity.magnified image
Polymer Composites for Thermoelectric Applications
Authors: McGrail Brendan T. , Sehirlioglu Alp , Pentzer Emily 
Published: December 2014

AbstractThis review covers recently reported polymer composites that show a thermoelectric (TE) effect and thus have potential application as thermoelectric generators and Peltier coolers. The growing need for CO2‐minimizing energy sources and thermal management systems makes the development of new TE materials a key challenge for researchers across many fields, particularly in light of the scarcity or toxicity of traditional inorganic TE materials based on Te and Pb. Recent reports of composites with inorganic and organic additives in conjugated and insulating polymer matrices are covered, as well as the techniques needed to fully characterize their TE properties.
Early Formation of the Ion‐Conducting Pore in Channelrhodopsin‐2
Authors: Kuhne Jens , Eisenhauer Kirstin , Ritter Eglof , Hegemann Peter , Gerwert Klaus , Bartl Franz 
Published: December 2014

AbstractChannelrhodopsins (ChRs) are light‐gated ion channels that are widely used in optogenetics. They allow precise control of neuronal activity with light, but a detailed understanding of how the channel is gated and the ions are conducted is still lacking. The recent determination of the X‐ray structural model in the closed state marks an important milestone. Herein the open state structure is presented and the early formation of the ion conducting pore is elucidated in atomic detail using time‐resolved FTIR spectroscopy. Photo‐isomerization of the retinal‐chromophore causes a downward movement of the highly conserved E90, which opens the pore. Molecular dynamic (MD) simulations show that water molecules invade through this opened pore, Helix 2 tilts and the channel fully opens within ms. Since E90 is a highly conserved residue, the proposed E90‐Helix2‐tilt (EHT) model might describe a general activation mechanism and provides a new avenue for further mechanistic studies and engineering.
Interplay of Hole Transfer and Host–Guest Interaction in a Molecular Dyad and Triad: Ensemble and Single‐Molecule Spectroscopy and Sensing Applications
Authors: Wu Xiangyang , Liu Fang , Wells Kym L. , Tan Serena L. J. , Webster Richard D. , Tan Howe‐Siang , Zhang Dawei , Xing Bengang , Yeow Edwin K. L. 
Published: December 2014

AbstractA new molecular dyad consisting of a Cy5 chromophore and ferrocene (Fc) and a triad consisting of Cy5, Fc, and β‐cyclodextrin (CD) are synthesized and their photophysical properties investigated at both the ensemble and single‐molecule levels. Hole transfer efficiency from Cy5 to Fc in the dyad is reduced upon addition of CD. This is due to an increase in the Cy5‐Fc separation (r) when the Fc is encapsulated in the macrocyclic host. On the other hand, the triad adopts either a Fc‐CD inclusion complex conformation in which hole transfer quenching of the Cy5 by Fc is minimal or a quasi‐static conformation with short r and rapid charge transfer. Single‐molecule fluorescence measurements reveal that r is lengthened when the triad molecules are deposited on a glass substrate. By combining intramolecular charge transfer and competitive supramolecular interaction, the triad acts as an efficient chemical sensor to detect different bioactive analytes such as amantadine hydrochloride and sodium lithocholate in aqueous solution and synthetic urine.
Macroscopic Self‐Assembly Based on Complementary Interactions between Nucleobase Pairs
Authors: Nakahata Masaki , Takashima Yoshinori , Hashidzume Akihito , Harada Akira 
Published: December 2014

AbstractWe have created a selective macroscopic self‐assembly process by using polymer gels modified with complementary DNA oligonucleotides or nucleobases. The hydrogels modified with complementary DNA oligonucleotides adhered to each other by simple contact. The organogels modified with complementary nucleobases selectively formed macroscopic assemblies by agitation in nonpolar organic solvents. The adhesion strength of each gel was estimated semi‐quantitatively by stress–strain measurements. We achieved direct adhesion between macroscopic materials both in water and in organic media, based on complementary hydrogen bonds.
Graphene Oxide Supported Molybdenum Cluster: First Heterogenized Homogeneous Catalyst for the Synthesis of Dimethylcarbonate from CO2 and Methanol
Authors: Kumar Subodh , Khatri Om P. , Cordier Stéphane , Boukherroub Rabah , Jain Suman L. 
Published: December 2014

AbstractThe octahedral molybdenum cluster‐based compound, Cs2Mo6Bri8Bra6 was immobilized on graphene oxide (GO) by using a facile approach. High resolution transmission electron microscopy results revealed that molybdenum clusters were uniformly distributed on the GO nanosheets. Cs2Mo6Bri8Bra6 was attached to the GO support via chemical interaction between apical ligands of Mo6Bri8Bra6 cluster units and oxygen functionalities of GO, as revealed by XPS studies. The developed material was used for the synthesis of dimethyl carbonate by reduction of carbon dioxide. The synthesized catalyst, that is, GO–Cs2Mo6Bri8Brax, exhibited higher catalytic efficiency than its homogeneous analogue without using dehydrating agent. The catalyst was found to be efficiently recyclable without significant loss of catalytic activity.
Chemistry of Diruthenium and Dirhodium Analogues of Pentaborane(9): Synthesis and Characterization of Metal N,S‐Heterocyclic Carbene and B‐Agostic Complexes
Authors: Roy Dipak Kumar , Mondal Bijan , Anju R. S. , Ghosh Sundargopal 
Published: December 2014

AbstractBuilding upon our earlier results on the synthesis of electron‐precise transition‐metal–boron complexes, we continue to investigate the reactivity of pentaborane(9) and tetraborane(10) analogues of ruthenium and rhodium towards thiazolyl and oxazolyl ligands. Thus, mild thermolysis of nido‐[(Cp*RuH)2B3H7] (1) with 2‐mercaptobenzothiazole (2‐mbtz) and 2‐mercaptobenzoxazole (2‐mboz) led to the isolation of Cp*‐based (Cp*=η5‐C5Me5) borate complexes 5 a,b [Cp*RuBH3L] (5 a: L=C7H4NS2; 5 b: L=C7H4NOS)) and agostic complexes 7 a,b [Cp*RuBH2(L)2], (7 a: L=C7H4NS2; 7 b: L=C7H4NOS). In a similar fashion, a rhodium analogue of pentaborane(9), nido‐[(Cp*Rh)2B3H7] (2) yielded rhodaboratrane [Cp*RhBH(L)2], 10 (L=C7H4NS2). Interestingly, when the reaction was performed with an excess of 2‐mbtz, it led to the formation of the first structurally characterized N,S‐heterocyclic rhodium‐carbene complex [(Cp*Rh)(L2)(1‐benzothiazol‐2‐ylidene)] (11) (L=C7H4NS2). Furthermore, to evaluate the scope of this new route, we extended this chemistry towards the diruthenium analogue of tetraborane(10), arachno‐[(Cp*RuCO)2B2H6] (3), in which the metal center possesses different ancillary ligands.
Total Synthesis and Absolute Configuration Assignment of MRSA Active Garcinol and Isogarcinol
Authors: Socolsky Cecilia , Plietker Bernd 
Published: December 2014

AbstractA short total synthesis of (±)‐garcinol and (±)‐isogarcinol, two endo‐type B PPAPs with reported activity against methiciline resistant Staphylococcus aureus (MRSA), is presented. The separation of framework‐constructing from framework‐decorating steps and the application of two highly regio‐ and stereoselective Pd‐catalysed allylations, that is, the Pd‐catalysed decarboxylative Tsuji–Trost allylation and the diastereoselective Pd‐catalysed allyl–allyl cross‐coupling, are key elements that allowed the total synthesis to be accomplished within 13 steps starting from acetylacetone. After separation of the enantiomers the absolute configurations of the four natural products (i.e., (−)‐garcinol, (+)‐guttiferone E (i.e., ent‐garcinol), (−)‐isogarcinol, and (+)‐isoxanthochymol (i.e., ent‐isogarcinol)) were assigned based on ECD spectroscopy.
Quality of life and satisfaction among prostate cancer patients followed in a dedicated survivorship clinic
Authors: Gilbert Scott M. , Dunn Rodney L. , Wittmann Daniela , Montgomery Jeffrey S. , Hollingsworth John M. , Miller David C. , Hollenbeck Brent K. , Wei John T. , Montie James E. 
Published: December 2014

BACKGROUNDIntegrating quality‐of‐life (QOL) outcomes into clinics may assist providers in identifying and responding to problems experienced by cancer survivors. To date, however, patient‐reported outcomes (PROs) such as QOL are used infrequently to guide care. We integrated QOL assessments into a prostate cancer survivorship clinic and compared recovery and satisfaction among men managed in the survivorship clinic with those followed with more routine care.METHODSWe conducted a before‐after study comparing 235 men treated surgically for prostate cancer who received routine follow‐up care with 102 men managed in a survivorship clinic characterized by point‐of‐care QOL reporting and integration of QOL scores (EPIC) following radical prostatectomy. We then assessed baseline and postprostatectomy QOL at 6 and 12 months, as well as patient satisfaction, and compared outcomes between groups.RESULTSAlthough baseline QOL was comparable, scores were generally higher among the survivorship group at 6 months and 1 year compared with those followed with routine care. In particular, sexual function scores were significantly higher among patients managed in the survivorship clinic (52.2 vs 33.6 at 1 year, P < .01). Satisfaction scores were consistently higher in the survivorship clinic group compared with the routine‐care group (all P < .05).CONCLUSIONSPatient QOL and satisfaction were higher among men managed in a survivorship program, suggesting that disease‐specific survivorship clinics that integrate QOL reporting into care pathways may yield better outcomes compared with less tailored approaches to patient care following cancer therapy. Cancer 2015;121:1484–1491. © 2014 American Cancer Society.
An ergonomic study of visual optimization by light color managements
Authors: Hsiao Shih‐Wen , Hsiao Yu‐Ting , Chen Shih‐Kai , Hsu Chiao‐Fei , Lee Chun‐Hsing , Chiang Ya‐Hui 
Published: December 2014

AbstractLight‐emitting diodes (LEDs) have the advantage of controllable light colors and provide the optimal lighting quality against various color attributes required in different environments. However, from the humanized design point of view, beside satisfying physical demands of people, it is also important to achieve satisfaction. With a good match between the LED lighting equipment and ambient colors, the space imagery that complies with psychological needs of human beings can be found. This is expected to become a new market direction for future lighting. In this study, the LED light source feature of adjustable correlated color temperature is used to match wall colors of typical commercial spaces and for the investigation and analysis of the impact of colors of light sources and environments on human beings. The measures of mental and subjective feelings of a group of people under various circumstances have also been investigated. Multivariate analysis of variance has been conducted on three color temperatures of light sources, six wall colors, and measures of five emotion adjectives, and the correlation between these three variables has been further investigated. © 2014 Wiley Periodicals, Inc. Col Res Appl, 41, 72–84, 2016
Scorpionato Halide Complexes [(TpPh,Me)Ni–X] [X = Cl, Br, I; TpPh,Me = Hydrotris(3‐phenyl‐5‐methyl‐1‐pyrazolyl)borate]: Structures, Spectroscopy, and Pyrazole Adducts
Authors: Deb Tapash , Anderson Caitlin M. , Ma Huaibo , Petersen Jeffrey L. , Young Victor G. , Jensen Michael P. 
Published: December 2014

AbstractPseudotetrahedral scorpionato halide complexes [(TpPh,Me)Ni–X] [TpPh,Me = hydrotris(3‐phenyl‐5‐methyl‐1‐pyrazolyl)borate] were synthesized by metathesis of Tl(TpPh,Me) and NiX2 (X = Cl, Br, I). Pyrazole adducts [(TpPh,Me)Ni(HpzPh,Me)(X)] (X = Cl, I) were also obtained. [(TpPh,Me)Ni–X] (X = Br, I) are isomorphous with previously reported [(TpPh,Me)Ni–Cl], and a new solvated pseudo‐polymorph [(TpPh,Me)Ni–Cl]·2CH2Cl2 was found in this work. Ni–X bond lengths correspond to ionic radii of the halide ions, but some variations in Ni–Cl and Ni–N bond lengths are respectively attributed to bending of the chloride from the ideal threefold HB···Ni axis and to the size of the 3‐pyrazole substituents. Electronic spectra were rationalized by means of time‐dependent (TD) DFT calculations on simplified C3v‐symmetric [(Tp)Ni–X] models. Exogenous pyrazole binds to give the pentacoordinate adducts [(TpPh,Me)Ni(HpzPh,Me)(X)] (X = Cl, I). We obtained a crystal structure of the iodide adduct, as well as that of [(TpPh,Me)Ni(HpzPh,Me)(Cl)]·0.5MeCN, isomorphous with a previously reported aquo monosolvate. A hallmark of adduct formation is an intramolecular N–H···X hydrogen bond between the added pyrazole and the adjacent halide ligand, thus giving rise to a strong IR absorption band. The stretching frequency correlates to the N(H)···X separation for the range of known adducts.
The longitudinal associations between C‐reactive protein and depressive symptoms: evidence from the English Longitudinal Study of Ageing (ELSA)
Authors: Au Bonnie , Smith Kimberley J. , Gariépy Geneviève , Schmitz Norbert 
Published: December 2014

ObjectivesThe inflammatory marker C‐reactive protein (CRP) is associated with depression. We examined the directional relations between CRP and symptoms of depression among older adults.MethodThe sample consisted of 3397 participants from the English Longitudinal Study of Ageing, a prospective study of community‐dwelling older adults. CRP and depressive symptoms were measured at baseline and follow‐up. A high CRP level was dichotomized as >3 mg/L. Elevated depressive symptomatology was defined as ≥4 using the 8‐item Center for Epidemiologic Studies Depression Scale. Logistic regressions computed the association between high CRP levels at baseline with elevated depressive symptoms at follow‐up, and vice versa.ResultsAfter adjusting for baseline depressive symptoms, baseline high CRP levels were associated with subsequent elevated symptoms of depression (OR = 1.49; 95% CI, 1.19–1.88). This relationship was no longer significant after simultaneous adjustments for metabolic and health variables. In the other direction, after adjusting for baseline CRP levels, baseline elevated depressive symptoms was not associated with subsequent high CRP levels (OR = 1.12; 95% CI, 0.88–1.42).ConclusionHigh CRP levels at baseline are related to elevated depressive symptomatology at follow‐up due to clinical factors. No association was found in the opposite direction. Copyright © 2014 John Wiley & Sons, Ltd.