bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Stemphylium lycopersici Extracts Immobilized on MCM‐48type Mesoporous Materials as Biocatalysts for Monoacylglycerol Production
Authors: Paranhos Bruno A. , Dallago Rogério M. , dos S. Martins Gustavo , Mignoni Marcelo L. , Valduga Eunice , Guimarães Denise O. , Itabaiana Ivaldo , Malafaia Camila R. A. , Leal Ivana C. R. 
Published: June 2024

AbstractMonoacylglycerols are eco‐friendly and inexpensive emulsifiers with a range of applications. The traditional synthetic route is not eco‐friendly, while enzymatic catalysis offers milder reaction conditions and higher selectivity. However, its application still is limited due to the costs. In this context, endophytic fungi can be source to new biocatalysts with enhanced catalytic activity. Based on this perspective, the aim of this study was perform the synthesis of MAG‘s through transesterification reactions of solketal and different vinyl esters, using crude and immobilized lipolytic extracts from the endophytic fungi Stemphylium lycopersici, isolated from Humiria balsamifera. The reactions were conducted using 100 mg of biocatalyst, 1 mmol of substrates, 9 : 1 n‐heptane/acetone, at 40 °C, 200 rpm for 96 h. In the reactions using the ILE and stearate, laureate and decanoate vinyl esters it was possible to obtain the correspondent products with conversion rates of 52–75 %. Also, according to the structure drivers used in MCM‐48 synthesis, different morphologies and conversions rates were observed. Employing [C16MI] Cl, [C14MI] Cl and [C4MI] Cl, the 1‐lauroyl‐ glycerol conversion was 36 %, 79 % and 44 %, respectively. This is the first work involving the immobilization of an endophytic fungi and its utilization as a biocatalyst in the production of MAG's.
Electrochemical Wastewater Treatment Technologies Through Life Cycle Assessment: A Review
Authors: Nath Soumitra 
Published: June 2024

AbstractElectrochemical wastewater treatment technologies are gaining attraction as sustainable alternatives for industrial and municipal wastewater management. This study conducts a comprehensive life cycle assessment to assess the environmental and economic sustainability of electrochemical methods such as electrocoagulation, electrooxidation, and electroreduction. By analyzing key stages, from raw material extraction to end‐of‐life disposal, the review aims to provide insight into their overall sustainability performance. The study also delves into environmental impact categories and utilization of methods used in quantifying the environmental implications. Moreover, a cost structure analysis and cost‐effectiveness evaluation offer insights into the economic viability of these technologies. Despite facing challenges like high initial costs and regulatory constraints, electrochemical technologies demonstrate competitive advantages in treatment efficiency and energy savings. Collaborative efforts and supportive policy frameworks are deemed crucial for overcoming barriers and fostering the widespread adoption of electrochemical technologies, thereby advancing sustainable wastewater management practices.
Outcomes of ultra‐low contrast percutaneous coronary intervention in patients with advanced chronic kidney disease
Authors: Sekerak Richard , Lerner Johanna Ben‐Ami , Garnett Christopher , McEntegart Margaret , Maehara Akiko , Ali Ziad , Fall Khady , Mohan Sumit , Ratner Lloyd E. , Leon Martin B. , Kirtane Ajay J. , Moses Jeffrey , Prasad Megha 
Published: June 2024

AbstractBackgroundCoronary angiography and percutaneous coronary intervention (PCI) in patients with chronic kidney disease (CKD) is associated with increased risk of contrast induced nephropathy (CIN) and requirement for renal replacement therapy (RRT).ObjectivesWe aimed to evaluate our single center experience of ultra‐low contrast PCI in patients with CKD and to characterize 1 year outcomes.MethodsWe performed a retrospective analysis of ultra‐low contrast PCI at our institution between 2016 and 2022. Patients with CKD3b‐5 (eGFR <45 mL/min/1.73m2), not on RRT who underwent ultra‐low contrast PCI ( < 30 mL of contrast during PCI) were included. Primary outcomes included change in eGFR post‐procedurally, and death, RRT requirement, and major adverse cardiac events (MACE) at 1 year follow‐up.ResultsOne hundred patients were included in the study. The median age was 67 years old and 28% were female. The median baseline eGFR was 21.5 mL/min/1.73m2 (IQR 14.08–32.0 mL/min/1.73m2). A median of 8.0 mL (IQR 0–15 mL) of contrast was used during PCI. Median contrast use to eGFR ratio was 0.37 (IQR 0‐0.59). There was no significant difference between pre‐and postprocedure eGFR (p = 0.84). At 1 year, 8% of patients died, 11% required RRT and 33% experienced MACE. The average time of RRT initiation was 7 months post‐PCI. Forty‐four patients were undergoing renal transplant evaluation, of which 17 (39%) received a transplant.ConclusionsIn patients with advanced CKD, ultra‐low contrast PCI is feasible and safe with minimal need for peri‐procedural RRT. Moreover, ultra‐low contrast PCI may allow for preservation of renal function in anticipation of renal transplantation.
Current applications, procedural and 1‐year outcomes of Rotatripsy for the treatment of calcified coronary lesions
Authors: van Oort Martijn J. H. , Al Amri Ibtihal , Bingen Brian O. , Oliveri Federico , Vilalta Victoria , Jurado‐Roman Alfonso , Pereira Ana Rita , Cordoba‐Soriano Juan G. , Rumiz González Eva , Fernández‐Peregrina Estefania , van der Kley Frank , Jukema J. Wouter , Montero‐Cabezas Jose M. 
Published: June 2024

AbstractBackgroundIntravascular lithotripsy (IVL) combined with rotational atherectomy (RA), known as Rotatripsy, is used to treat severe coronary artery calcification (CAC), though data on efficacy, midterm safety and use sequence is limited. We aimed to identify indicators for Rotatripsy use and to assess its safety and success rates, both acutely and at 1‐year follow‐up.MethodsPatients undergoing Rotatripsy for severe CAC across six centers from May 2019 to December 2023 were included. Demographic, clinical, procedural and follow‐up data were collected. Efficacy endpoints included device success (delivery of the RA‐burr and IVL‐balloon across the target lesion and administration of therapy without related complications), technical success (TIMI 3 flow and residual stenosis <30% by quantitative coronary analysis) and procedural success [composite of technical success with absence of in‐hospital major adverse cardiovascular events (MACE: cardiac death, myocardial infarction or target vessel revascularization). Safety endpoints comprised Rotatripsy‐related complications and MACE at 1‐year follow‐up.ResultsA total of 114 patients (75 ± 9 years, 78% male) underwent Rotatripsy for 120 lesions. In the majority of procedures RA was followed by IVL, mostly electively (n = 68, 57%) but also for balloon underexpansion (n = 37, 31%) and stent crossing failure (n = 1, 1%). Diverse and complex target lesions were addressed with an average SYNTAX score of 24.6 ± 13.0. Device, technical and procedural success were 97%, 94% and 93%, respectively. Therapy‐related complications included two (2%) coronary perforations, one (1%) coronary dissection and one (1%) burr entrapment. At 1‐year follow‐up(present in 77(67%) patients), MACE occurred in 7(9%) cases.ConclusionsOver a 1‐year follow‐up period, Rotatripsy was safe and effective, predominantly using RA electively before IVL.
Coronary artery intramural hematoma causing myocardial infarction mimicking pseudoaneurysm or dissection from trauma: A case report
Authors: Albriek Abdulilah Z. , Alamri Saad , Hamad Faisal , Alshamiri Mostafa 
Published: June 2024

Key Clinical MessageBlunt chest trauma caused ST‐segment elevation myocardial infarction. Diagnosis of intramural hematoma (IMH) using computed tomography was confirmed using electrocardiography, cardiac marker tests, and subsequent coronary angiography. After conservative treatment, the hematoma was completely resolved 1 year later. Differentiating IMH from other arterial injuries is critical for appropriate management.
Ethylene Dimerization, Isomerization and Trimerization: Mechanistic Insights into Competing Pathways on Metal–Organic Framework Supported Metal Hydrides
Authors: Hashem Karam , Yang Kuiwei , Krishnan Ramakrishna , Zhang Yugen , Jiang Jianwen 
Published: June 2024

AbstractCatalytic ethylene oligomerization is important in the petrochemical industry, as it produces valuable products like linear alpha‐olefins (LAOs) for the synthesis of polymers and specialty chemicals. Catalysts, typically transition metal complexes or metal‐containing materials, play a crucial role in selective oligomerization by providing active sites for ethylene activation and controlling product distribution. Recently, defective metal‐organic frameworks (MOFs) with well‐defined structures and unsaturated active sites have emerged as potential catalysts for ethylene oligomerization. In this study, we employ density functional theory calculations to investigate the energetic selectivity of competing pathways (including dimerization, isomerization and trimerization) during ethylene oligomerization on defective HKUST‐1 supported metal hydrides (H−M–DHKUST‐1, M: Co, Ni, Ru, Rh and Pd). On all the five hydrides, ethylene dimerization is found to be more preferential than trimerization and isomerization. In the microenvironment of defective paddlewheel of HKUST‐1, isomerization is highly unfavorable compared with dimerization because of high energy required for chain walk, and 1‐butene is expected to be the major product on all the five hydrides. Analysis of NBO charges reveals a notable reduction in cationic nature at the metal site on H−Ru–DHKUST‐1, which facilitates β‐hydride elimination for dimerization. The microscopic insights from this computational study might facilitate the rational design of new MOFs and other MOF‐supported catalysts for selective ethylene oligomerization.
Selenylation of N‐(P‐Methoxyaryl)Propiolamides via CuBr2 Catalysis: Synthesis of 3‐Selenospiro[4,5]Decatrienones via Ipso‐Cyclization
Authors: Cai Jinhui , Cen Kaili , Lin Hongyi , Zhang Haixia , Zhou Nannan , Wang Qiaolin 
Published: June 2024

AbstractHerein, a method for the assembly of biologically valuable 3‐selenospiro[4,5]decatrienones through CuBr2‐catalyzed ispo‐cyclization of Se powder, boronic acids, and N‐(p‐methoxyaryl)propiolamides has been established. In this protocol, noble transition metal, prefunctionalized selenylation reagent, and strong chemical oxidant are not employed. This method feature wide substrate scope, good functional group tolerance, easy operation, and employing earth‐abundant metal as catalyst and green air as oxidant. Furthermore, several derivatizations of 3‐selenospiro[4,5]decatrienones are performed to showcase the practicability of our strategy.
Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1
Authors: Huber Max E. , Wurnig Silas L. , Moumbock Aurélien F. A. , Toy Lara , Kostenis Evi , Alonso Bartolomé Ana , Szpakowska Martyna , Chevigné Andy , Günther Stefan , Hansen Finn K. , Schiedel Matthias 
Published: June 2024

AbstractA conserved intracellular allosteric binding site (IABS) was recently identified at several G protein‐coupled receptors (GPCRs). This target site allows the binding of allosteric modulators and enables a new mode of GPCR inhibition. Herein, we report the development of a NanoBRET‐based assay platform based on the fluorescent ligand LT221 (5), to detect intracellular binding to CCR6 and CXCR1, two chemokine receptors that have been pursued as promising drug targets in inflammation and immuno‐oncology. Our assay platform enables cell‐free as well as cellular NanoBRET‐based binding studies in a nonisotopic and straightforward manner. By combining this screening platform with a previously reported CXCR2 assay, we investigated CXCR1/CXCR2/CCR6 selectivity profiles for both known and novel squaramide analogues derived from navarixin, a known intracellular CXCR1/CXCR2 antagonist and phase II clinical candidate for the treatment of pulmonary diseases. By means of these studies we identified compound 10, a previously reported tert‐butyl analogue of navarixin, as a low nanomolar intracellular CCR6 antagonist. Further, our assay platform clearly indicated intracellular binding of the CCR6 antagonist PF‐07054894, currently evaluated in phase I clinical trials for the treatment of ulcerative colitis, thereby providing profound evidence for the existence and the pharmacological relevance of a druggable IABS at CCR6.
Simple Solution Plasma Synthesis of Ni@NiO as High‐Performance Anode Material for Lithium‐Ion Batteries Application
Authors: Beletskii Evgenii , Pinchuk Mikhail , Snetov Vadim , Dyachenko Aleksandr , Volkov Alexey , Savelev Egor , Romanovski Valentin 
Published: June 2024

AbstractPursuing of straightforward and cost‐effective methods for synthesizing high‐performance anode materials for lithium‐ion batteries is a topic of significant interest. This study elucidates a one‐step synthesis approach for a conversion composite using glow discharge in a nickel formate solution, yielding a composite precursor comprising metallic nickel, nickel hydroxide, and basic nickel salts. Subsequent annealing of the precursor facilitated the formation of the Ni@NiO composite, exhibiting exceptional electrochemical properties as anode material in Li‐ion batteries: a capacity of approximately 1000 mAh g−1, cyclic stability exceeding 100 cycles, and favorable rate performance (200 mAh g−1 at 10 A g<M−.1). Comparative analysis across various methods for synthesizing NiO‐based materials underscored the superiority of the Ni@NiO composite. Furthermore, an assessment of resource costs demonstrated the cost‐effectiveness and scalability of the approach in terms of resource consumption per Ah. Lastly, the integration of a Ni@NiO anode with an NMC532 cathode in a full battery highlights Ni@NiO's potential for conversion anodes, achieving a practical gravimetric energy density of 92 Wh kg−1.
The Mechanism of Inhomogeneous Mass Transfer Process of Separators in Lithium‐Ion Batteries
Authors: Li Na , Yin Shuaimeng , Meng Yufeng , Gu Meirong , Feng Zhenhe , Lyu Siqi , Chen Hao‐Sen , Song Wei‐Li , Jiao Shuqiang 
Published: June 2024

AbstractThe liquid‐phase mass transport is the key factor affecting battery stability. The influencing mechanism of liquid‐phase mass transport in the separators is still not clear, the internal environment being a complex multi‐field during the service life of lithium‐ion batteries. The liquid‐phase mass transport in the separators is related to the microstructure of the separator and the physicochemical properties of electrolytes. Here, in‐situ local electrochemical impedance spectra were developed to investigate local inhomogeneities in the mass transfer process of lithium‐ion batteries. The geometric microstructure of the separator significantly impacts the mass transfer process, with a reduction in porosity leading to increased overpotentials. A competitive relationship among porosity, tortuosity, and membrane thickness in the geometric parameters of the separator were established, resulting in a peak of polarization. The resistance of the liquid‐phase mass transfer process is positively correlated with the viscosity of the electrolyte, hindering ion migration due to high viscosity. Polarization is closely related to the electrochemical performance, so a phase diagram of battery performance and inhomogeneous mass transfer was developed to guide the design of the battery. This study provides a foundation for the development of high stability lithium‐ion batteries.
Comprehensive Review of Li‐Rich Mn‐Based Layered Oxide Cathode Materials for Lithium‐Ion Batteries: Theories, Challenges, Strategies and Perspectives
Authors: Chen Huai , Xia Xiao , Ma Jun 
Published: June 2024

AbstractLithium‐rich manganese‐based layered oxide cathode materials (LLOs) have always been considered as the most promising cathode materials for achieving high energy density lithium‐ion batteries (LIBs). However, in practical applications, LLOs often face some key problems, such as low initial coulombic efficiency, capacity/voltage decay, poor rate performance and poor cycle stability. It seriously shortens the lifespan of lithium‐ion batteries and hinder the large‐scale commercial application of LLOs. Herein, firstly, the basic theories of LLOs were systematically reviewed, including the structural characteristics, the working mechanism of LLOs, the preparation methods of LLOs (liquid phase co‐precipitate method, sol‐gel method, hydrothermal synthesis method, solid phase method, low heat solid‐phase method, high temperature solid‐state method etc.), and electrochemical characteristics of LLOs (first charge discharge characteristics and reversible efficiency, cycling performance, high and low temperature performance and thermal stability etc.). Then, key challenges faced by LLOs were systematically discussed. Finally, the LLOs modification strategies used to address these challenges (element doping, surface modification, defect engineering, structural and morphological control etc.) were elaborated in detail. This important review provides potential insights and directions for further improving the electrochemical performance of LLOs, and provides a necessary theoretical basis for accelerating the large‐scale commercial application of LLOs. It possesses important scientific research value and far‐reaching social significance.
Siglec‐1, an easy and contributory inflammation marker in rheumatology
Authors: Boz Valentina , Tesser Alessandra , Burlo Francesca , Donadel Nicola , Pastore Serena , Amaddeo Alessandro , Vittoria Francesca , Padovan Matteo , Di Rosa Marianna , Tommasini Alberto , Valencic Erica 
Published: June 2024

AbstractObjectivesInflammatory markers such as erythrocyte sedimentation rate (ESR) and C‐reactive protein (CRP) are poorly informative about interferon (IFN)‐related disorders. In these conditions, the measure of the interferon score (IS), obtained by measuring the expression of IFN‐stimulated genes, has been proposed. Flow cytometry‐based assays measuring sialic‐acid‐binding Ig‐like lectin 1 (Siglec‐1) expression could be a more practical tool for evaluating IFN‐inflammation. The study compared Siglec‐1 measures with IS and other inflammatory indexes. We compared Siglec‐1 measures with IS and other inflammatory indexes in real‐world paediatric rheumatology experience.MethodsWe recruited patients with immuno‐rheumatological conditions, acute infectious illness and patients undergoing orthopaedic surgery as controls. Siglec‐1 expression was measured in all samples, and IS, ESR and CRP were also recorded if available.ResultsOverall, 98 subjects were enrolled in the study, with a total of 104 measures of Siglec‐1. Compared with IS, Siglec‐1 expression showed good accuracy (86.0%), specificity (72.7%) and sensitivity (85.7%). The measure of the percentage of Siglec‐1‐positive cells performed best at low levels of IFN‐inflammation, while the measure of mean fluorescence intensity performed best at higher levels. Ex vivo studies on IFN‐stimulated monocytes confirmed this behaviour. There was no link between Siglec‐1 expression and either ESR or CRP, and positive Siglec‐1 results were found even when ESR and CRP were normal. A high Siglec‐1 expression was also recorded in subjects with acute infections.ConclusionSiglec‐1 measurement by flow cytometry is an easy tool to detect IFN‐related inflammation, even in subjects with normal results of common inflammation indexes.
Why are there so many definitions of eutrophication?
Authors: Pannard Alexandrine , Souchu Philippe , Chauvin Christian , Delabuis Monique , Gascuel‐Odoux Chantal , Jeppesen Erik , Le Moal Morgane , Ménesguen Alain , Pinay Gilles , Rabalais Nancy N. , Souchon Yves , Gross Elisabeth M. 
Published: June 2024

AbstractBecause of the first observations in the 1900s of the oligotrophic and eutrophic states of lakes, researchers have been interested in the process that makes lakes become turbid because of high phytoplankton biomass. Definitions of eutrophication have multiplied and diversified since the mid‐20th century, more than for any other ecological process. Reasons for the high number of definitions might be that the former ones did not sufficiently describe their causes and/or consequences. Global change is bringing eutrophication more into the spotlight than ever, highlighting the need to find consensus on a common definition, or at least to explain and clarify why there are different meanings of the term eutrophication. To find common patterns, we analyzed 138 definitions that were classified by a multiple correspondence factor analysis (MCA) into three groups. The first group contains the most generic scientific definitions but many of these limit the causes to increased nutrient availability. A single definition takes into account all causes but would require additional work to clarify the process itself. Nutrient pollution, which is by far the primary cause of eutrophication in the Anthropocene, has generated a second group of environmental definitions that often specify the primary producers involved. Those definitions often mention the iconic consequences of nutrient pollution, such as increased algal biomass, anoxia/hypoxia and reduced biodiversity. The third group contains operational definitions, focusing on the consequences of nutrient pollution, for ecosystem services and therefore associated with ecosystem management issues. This group contains definitions related to regulations, mainly US laws and European directives. These numerous definitions, directly derived from the problem of nutrient pollution, have enlarged the landscape of definitions, and reflect the need to warn, legislate and implement a solution to remedy it. Satisfying this demand should not be confused with scientific research on eutrophication and must be based on communicating knowledge to as many people as possible using the simplest possible vocabulary. We propose that operational definitions (groups 2 and 3) should name the process “nutrient pollution,” making it possible to refine (scientific) definitions of eutrophication and to expand on other challenges such as climate warming, overfishing, and other nonnutrient‐related chemical pollutions.