bluuebunny/crossref_metadata_2025_split huggingface dataset:
De oprichting van de ‘Nederlandsche Vereeniging voor Tropische Geneeskunde’: een zaak van nationaal belang
Authors: Van Bergen Leo 
Published: October 2015

The foundation of the Dutch Society for Tropical Medicine: an affair of national importance The ‘Nederlandsche Vereeniging voor Tropische Geneeskunde’ (Dutch Society for Tropical Medicine – in short: NVTG) was founded in 1907, a time not only of colonial expansion, but also a time in which the economic interest of the Dutch East-Indies for the Netherlands grew exceptionally. This had its effect on the motivations behind medical aid. Hygienic measures were financially backed because healthy workers had a positive effect on profits. This atmosphere of economic interest and political-military expansion had its effect on the foundation of the NVTG as well. Colonialism was generally approved of, and the goal of the society – apart from sociability motives – was to support research into illnesses torturing mainly the Dutch colonies. This was in line with the reasoning that the colonies were rightfully governed by the Netherlands, because the peoples living there had proven not to be able to look after themselves in a proper manner. The foundation of the Society should have been a part of the foundation of an international society for tropical medicine, but this failed. Although internationalism generally was seen as an important feature of science and certainly of medical science, it is not strange this was not seen as a major problem. For it was national and not international reasons that had led to founding the Dutch society. It was the Dutch position as a colonial power that had convinced Dutch tropical doctors a society should be called into being. A generally shared spirit of internationalism had little to do with this unless internationalism is defined as: what others have, we need to have as well, and let us see in international conferences what could be of national benefit. That nevertheless this spirit of internationalism – and not nationalism – is commonly hailed as the main reason behind the foundation, is probably due to the fact that around 1900 nationalism was such a normal state of mind and so fully incorporated in man’s way of thinking and acting, that, as for instance was the case with racism, it was hardly noticed and recognised as such.
Advertenties voor hypnotica en sedativa in het Nederlands Tijdschrift voor Geneeskunde, 1900-1940: historische veranderingen in de vorm en inhoud van een informatiebron voor artsen
Authors: Van der Hoogte Arjo Roersch , Pieters Toine 
Published: October 2015

Drug advertising as communication between the pharmaceutical industry and the physician: Advertisements for psychotropic drugs in the Dutch medical journal, Nederlands Tijdschrift voor Geneeskunde, 1900-1940 In this article we explore the historical development of drug advertisements for psychotropic drugs in the leading Dutch medical journal from 1900 to 1940. The advertisements for hypnotics and sedatives, in the Nederlands Tijdschrift voor Geneeskunde (Dutch medical journal) reflected the changes in the vocabulary and image promoted by the pharmaceutical companies. In the first two decades, the advertisements were sober and to the point, and included the trademark, company name, molecular formula and therapeutic properties of the medication. The emphasis was on creating a scientific image of reliable symptom control for the therapeutic drug. In doing so, the ethical drug companies tried (successfully) to distinguish themselves from the producers of patent medicines. Once scientific credibility was established, the form and content of the advertisements changed significantly. In the late 1920s and 1930s drug companies embraced modern advertising techniques, developing a figurative language to address the changing beliefs and practices of Dutch physicians. Instead of promoting therapeutic drugs as safe and scientific, the emphasis was on their effectiveness in comparison to similar drugs. In the process, scientific information was reduced to an indispensable standardized minimum, whereby therapeutic drugs were advertised according to the latest pharmacological taxonomy rather than molecular formulas. The image-making of ‘ethical marketing’ began during the interwar years when marketers applied modern advertising techniques and infotainment strategies. The scanty black and white informational bulletins transitioned into colourful advertisements. The pharmaceutical companies employed the same medical language as used by physicians, so that one word or image in an advertisement would suffice for the physician to recognize a drug and its therapeutic properties. These developments show the changing relationship between the modern ethical pharmaceutical industry and Dutch doctors during the interwar years – from rapprochement towards concerted action.
Een heilzame vergissing. Het urine- en fecaliënprobleem van Grieken tot Gouwenaars
Authors: Tilburg Cornelis 
Published: October 2015

Nowadays, faeces and urine are considered as noxious and unhealthy. In ancient times, however, urine and excrements were seen as undangerous and even useful; urine for textile production and excrements for agriculture. The Romans constructed sewers like the Cloaca Maxima, in the first place to remove (rain)water and drainage. Only later, toilets were connected to these sewers to remove the smell of urine and excrements. The idea that sewers were constructed with the specific aim of removing urine and excrements is therefore no longer valid, but the memory of this function of the (Roman) sewers was maintained in the Middle Ages.From the Renaissance onwards, city planners developed their ‘ideal cities’. In these cities, there was no place for the dirty smell of urine and excrements, so subterranean sewers had to be constructed. Yet such ideas proved difficult to implement in the Dutch context. The Dutch engineer Simon Stevin realised that the situation described by the ancient and Renaissance sources did not offer a solution for the problems in Dutch cities, with standing water in canals and without natural drainage. Moreover, in this period there was not yet an awareness of the relation between the presence and smell of urine and excrements, on the one hand, and hygiene and public health on the other.Awareness of this relation came not earlier than the 18th century. The German physician Johann Peter Frank argued in favour of diminishing the bad smell by means of filling up canals; the city physician Willem Frederik Büchner was confronted with the extremely unhealthy situation in the typical Dutch city of Gouda. But their political influence was small. Only at the end of the 19th century, the construction of sewers began in Dutch cities, thus – improving health conditions.
The Savvy Separator Series: Part 3. Scrubber Debottlenecking
Authors: Chin Robert W. , van Asperen Victor , Riesenberg J. M. , McVinnie Graham 
Published: October 2015

The SPE Separations Technology Technical Section's series of articles on separator design, lessons learned, and solutions for separation problems continues with the decription of an underperforming scrubber that was suffering from too much oil carry-over. The consequences of this carry-over for the processing system are explained, a brief analysis of the scrubber design is presented, and the potential causes for the underperformance are listed. Several options for resolving the problem are discussed, and the selected option is summarized along with a comparison of the separation performance data obtained before and after the modification.
Innovative Assessments for Selecting Offshore-Platform-Decommissioning Alternatives
Authors: Truchon Stephen P. , Brzuzy Louis P. , Fawcett Deborah , Fonseca Mark 
Published: October 2015

Summary
Hard substrates associated with offshore oil and gas platforms can contribute to the productivity of marine ecosystems, thereby generating local and regional economic benefits. These benefits form the basis for incorporating the platform into a rigs-to-reefs program when it is retired or for selecting some other type of removal option. There are many options for reefing platforms, each differing in environmental impact associated with dismantling and transport of the platform structure (deck, jacket, and other subsea structures). The use of science-based decision making in exploring platform-removal options can be beneficial for all stakeholders in the context of regulatory environment, complex ecosystem, and human interactions across multiple scales. Accommodating these complexities in a decisionmaking process is the foundation of an ecosystem-based-management (EBM) approach. EBM is an environmental-management approach that recognizes the full array of interactions within an ecosystem, including humans, rather than considering single issues, species, or ecosystem services in isolation (Christensen et al. 1996; McLeod et al. 2005; Altman et al. 2011).
The focus of this study is on one of Shell's former deepwater assets in the Gulf of Mexico. The fixed-jacket platform has been in operation for more than 35 years and extends to more than 1,000 ft of water depth off the coast of Louisiana. Few studies have been published on the ecology of marine life inhabiting deepwater platforms such as these. To begin to understand the specific contribution of this platform as an artificial reef, a stratified (across depth down the platform) study was performed by use of routinely collected remotely-operated-vessel (ROV) video footage to assess fish and sessile biotic communities. The ROV study revealed clear depth-related patterns of visually conspicuous epibiota (surface-dwelling organisms such as Lophelia pertusa) and numerous species of reef and pelagic fishes. These data were used to construct a matrix to rank the ecosystem services of several decommissioning alternatives, including complete removal of the deck and jacket; removal of the deck, topping the jacket 85 ft below the waterline, and leaving the remainder in place; and removal of the deck and transfer of the entire jacket to a rigs-to-reef location. This portion of the assessment provided a strategic framework for identifying and evaluating sensitive ecosystem services in association with both human and environmental drivers to provide realistic (actionable) guidance in the selection of these decommissioning options. The preliminary ranking illustrated that a high level of ecosystem services could be maintained by decommissioning alternatives that leave the jacket in place or transfer the jacket elsewhere as part of a rigs-to-reefs program.
A new species of Neossos Malloch (Diptera: Heleomyzidae) from the Yukon Territory, Canada, and a revised key to the Nearctic species
Authors: Solecki Anna , Wheeler Terry 
Published: October 2015

The rarely collected genus Neossos Malloch contains three Nearctic and one western European species. Most known specimens have been collected from bird nests. Two specimens of an undescribed species of Neossos were collected by sweeping in subarctic tundra and a mesic meadow in the Yukon Territory, Canada. This represents a significant northward extension of the known Nearctic range of the genus.
Neossos tombstonensissp. n. is described from the Yukon Territory. This represents the fourth described Nearctic species of Neossos. Although the type specimens were collected by sweeping, the species is predicted to be associated with bird nests, based on habits of other members of the genus. A revised key to the Nearctic species of Neossos is provided.
PIRO concept
Authors: Rathour S , Kumar S , Hadda V , Bhalla A , Sharma N , Varma S 
Published: October 2015

Introduction:
Sepsis is common presenting illness to the emergency services and one of the leading causes of hospital mortality. Researchers and clinicians have realized that the systemic inflammatory response syndrome concept for defining sepsis is less useful and lacks specificity. The predisposition, infection (or insult), response and organ dysfunction (PIRO) staging of sepsis similar to malignant diseases (TNM staging) might give better information.

Materials and Methods:
A prospective observational study was conducted in emergency medical services attached to medicine department of a tertiary care hospital in Northern India. Patients with age 18 years or more with proven sepsis were included in the first 24 hours of the diagnosis. Two hundred patients were recruited. Multivariate logistic regression analysis was done to assess the factors that predicted in-hospital mortality.

Results:
Two hundred patients with proven sepsis, admitted to the emergency medical services were analysed. Male preponderance was noted (M: F ratio = 1.6:1). Mean age of study cohort was 50.50 ± 16.30 years. Out of 200 patients, 116 (58%) had in-hospital mortality. In multivariate logistic regression analysis, the factors independently associated with in-hospital mortality for predisposition component of PIRO staging were age >70 years, chronic obstructive pulmonary disease, chronic liver disease, cancer and presence of foley's catheter; for infection/ insult were pneumonia, urinary tract infection and meningitis/encephalitis; for response variable were tachypnea (respiratory rate >20/minute) and bandemia (band >5%). Organ dysfunction variables associated with hospital mortality were systolic blood pressure <90mm Hg, prolonged activated partial thromboplastin time, raised serum creatinine, partial pressure of oxygen in arterial blood/ fraction of inspired oxygen (PaO2 /FiO2) ratio <300, decreased urine output in first two hours of emergency presentation and Glasgow coma scale ≤9. Each of the components of PIRO had good predictive capability for in-hospital mortality but the total score was more accurate than the individual score and increasing PIRO score was associated with higher in-hospital mortality. The area under receiver operating characteristic curve for cumulative PIRO staging system as a predictor of in-hospital mortality was 0.94.

Conclusion:
This study finds PIRO staging as an important tool to stratify and prognosticate hospitalised patients with sepsis at a tertiary care center. The simplicity of score makes it more practical to be used in busy emergencies as it is based on four easily assessable components.
Incidence and factors associated with medication nonadherence in patients with mental illness
Authors: Lucca JM , Ramesh M , Parthasarathi G , Ram D 
Published: October 2015

Background:
In spite of the progress made in the treatment of psychiatric disorders during the last few decades, nonadherence continues to be a frequent phenomenon, often associated with potentially severe clinical consequences and increased health-care costs. There are numerous factors associated with medication nonadherence in patients with mental illness. The aim of the study was to determine the incidence and factors associated with medication nonadherence among psychiatric outpatients.

Materials and Methods:
A cross-sectional study was carried out in the outpatient psychiatric department of an Indian tertiary care private hospital over a period of 1 year. Patients aged 18 years and above who presented with mental illness as diagnosed by the International Classification of Diseases (ICD)-10 and who were receiving at least one psychotropic medication for at least 1 month were included in the study. Medication adherence was assessed using the Medication Adherence Rating Scale (MARS).

Results:
Of the 400 patients, 172 (43%) were nonadherent to their prescribed medications. There is a statistically significant association between the education (P = 0.001), number of drugs (P = 0.002), family income (P = 0.013), and nonadherence. Among the 172 patients, 33.5 % were nonadherent to their therapy due to patient-related factors followed by drug-related factors (32%) and disease-related factors (31%).

Conclusion:
The overall incidence of medication nonadherence in patients with mental illness was 43%. Numerous factors contributed to medication nonadherence. Strategies need to be developed and implemented to enhance medication adherence, and thereby achieve a better therapeutic outcome in patients with mental illness.
An audit of consent refusals in clinical research at a tertiary care center in India
Authors: Thaker SJ , Figer BH , Gogtay NJ , Thatte UM 
Published: October 2015

Background and Rationale:
Ensuring research participants’ autonomy is one of the core ethical obligations of researchers. This fundamental principle confers on every participant the right to refuse to take part in clinical research, and the measure of the number of consent refusals could be an important metric to evaluate the quality of the informed consent process. This audit examined consent refusals among Indian participants in clinical studies done at our center.

Materials and Methods:
The number of consent refusals and their reasons in 10 studies done at our center over a 5-year period were assessed. The studies were classified by the authors according to the type of participant (healthy vs patients), type of sponsor (investigator-initiated vs pharmaceutical industry), type of study (observational vs interventional), level of risk [based on the Indian Council of Medical Research (ICMR) "Ethical Guidelines for Biomedical Research on Human Participants"], available knowledge of the intervention being studied, and each patient's disease condition.

Results:
The overall consent refusal rate was 21%. This rate was higher among patient participants [23.8% vs. healthy people (14.9%); P = 0.002], in interventional studies [33.6% vs observational studies (7.5%); P < 0.0001], in pharmaceutical industry-sponsored studies [34.7% vs investigator-initiated studies (7.2%); P < 0.0001], and in studies with greater risk (P < 0.0001). The most common reasons for consent refusals were multiple blood collections (28%), inability to comply with the study protocol (20%), and the risks involved (20%).

Conclusion:
Our audit suggests the adequacy and reasonable quality of the informed consent process using consent refusals as a metric.
A Tool to Assess Family Medicine Residents' Patient Encounters Using Secure Messaging
Authors: Kim Jung G. , Morris Carl G. , Heidrich Fred E. 
Published: October 2015

ABSTRACT

Background
Secure messages exchanged between patients and family medicine residents via an electronic health record (EHR) could be used to assess residents' clinical and communication skills, but the mechanism is not well understood.

Objective
To design and test a secure messaging competency assessment for family medicine residents in a patient-centered medical home (PCMH).

Methods
Using the existing literature and evidence-based guidelines, we designed an assessment tool to evaluate secure messaging competency for family medicine residents training in a PCMH. Core faculty performed 2-stage validity and reliability testing (n = 2 and n = 9, respectively). A series of randomly selected EHR secure messages (n = 45) were assessed from a sample of 10 residents across all years of training.

Results
The secure message assessment tool provided data on a set of competencies and a framework for resident feedback. Assessment showed 10% (n = 2) of residents at the novice level, 50% (n = 10) as progressing, and 40% (n = 8) as proficient. The most common deficiencies for residents' secure messages related to communication rather than clinical competencies (n = 37 [90%] versus n = 4 [10%]). Interrater reliability testing ranged from 60% to 78% agreement and 20% to 44% disagreement. Disagreement centered on interpersonal communication factors. After 2 stages of testing, the assessment using residents' secure messages was incorporated into our existing evaluation process.

Conclusions
Assessing family medicine residents' secure messaging for patient encounters closed an evaluation gap in our family medicine program, and offered residents feedback on their clinical and communication skills in a PCMH.
Multisite Study to Examine the Amount of Inpatient Physician Continuity Experienced by Hospitalized Patients
Authors: Fletcher Kathlyn E. , Singh Siddhartha , Whittle Jeff , Ratkalkar Vishal , Visotcky Alexis M. , Laud Purushottam , Kordus Andrew , Schapira Marilyn M. 
Published: October 2015

ABSTRACT

Background
Continuity for inpatient medicine has been widely discussed, but methods for measuring it have been lacking.

Objective
To measure the continuity of care experienced by hospitalized patients and to identify predictors of continuity.

Methods
This was a multisite prospective cohort study and retrospective chart review that took place at 3 hospitals: an academic tertiary care center, a Veterans Affairs medical center, and a community teaching hospital. Subjects were general medicine patients and internal medicine residents. We measured continuity of care using 3 metrics: (1) the percentage of hospital time covered by the primary intern; (2) the amount of time between admission and the first handoff of care; and (3) admission-discharge continuity. We conducted univariate analyses to identify patient and hospital factors that may be associated with each type of continuity of care.

Results
Our sample included 869 patients with a mean age of 62.6 years (SD = 17.2) and 34% female patients. The mean percentage of hospital time covered by the primary intern was 39.2% (SD = 16.3%). The mean time between admission and the first handoff of care was 13.3 hours (SD = 7.1). Forty percent of patients experienced admission-discharge continuity. In univariate and multivariable modeling, the site was significantly associated with each type of continuity.

Conclusions
The amount of continuity varied greatly and was influenced by the site and other factors. No site maximized every aspect of continuity. Programs and institutions should decide which aspects of continuity are most important locally and design schedules accordingly.
Residency as a Social Network: Burnout, Loneliness, and Social Network Centrality
Authors: Shapiro Jordan , Zhang Bin , Warm Eric J. 
Published: October 2015

ABSTRACT

Background
Burnout is typically viewed as an individual condition, and no link has been identified between burnout and loneliness.

Objective
To investigate the association of burnout with loneliness and social network degree and centrality.

Methods
A survey containing the Maslach Burnout Inventory (MBI), a 3-question loneliness scale, and a social connectivity component was sent to residents in a large urban academic medical center internal medicine residency program.

Results
The response rate was 77% (95 of 124 residents). We defined significant burnout as MBI subscores of ≥ 27 for emotional exhaustion (EE), ≥ 10 for depersonalization (DP), or both. This was met by 43 (45%), 47 (49%), and 31 (33%) out of 95 respondents, respectively. Those with significant burnout had higher loneliness scores: 5.6 versus 4.5 for EE (P = .002; OR = 1.50; 95% CI 1.15–1.95); 5.4 versus 4.6 for DP (P = .024; OR = 1.33; 95% CI 1.03–1.71); and 5.8 versus 4.6 for both EE and DP (P = .001; OR = 1.54; 95% CI 1.17–2.02). Rating a larger number of coresidents as closer connections on a 5-point Likert scale was not associated with lower burnout scores. No measures of centrality were associated with burnout scores for EE and/or DP. High personal accomplishment subscores on the MBI did correlate significantly with several measures of centrality.

Conclusions
Burnout was associated with loneliness in a dose-dependent fashion. Greater sense of personal accomplishment was associated with greater network centrality.