bluuebunny/crossref_metadata_2025_split huggingface dataset:
240-OR: Longitudinal Assessment of Glycemia and Severe Hypoglycemia among Adults with Type 1 Diabetes—An Online Survey
Authors: SHERR JENNIFER L. , HAGAN KAITLIN , BHAK RACHEL , PETER MEGAN , NGUYEN HUYEN , WANG CHENKUN , PAKALAPATI TATHABBAI , SHERWOOD JORDAN , GUPTA TINA , GAGLIA JASON L. , CORNELIUS EMILEE M. , CHAPMAN KATHERINE S.M. , WOLF WENDY , PETTUS JEREMY 
Published: July 2024

Introduction & Objective: Longitudinal trends of glycemia and severe hypoglycemic events (SHE) among individuals with T1D are not well described, particularly in those using diabetes technologies (i.e., continuous glucose monitors [CGM], automated insulin delivery [AID]).
Methods: An online survey recruited adults with T1D through the T1D Exchange Registry or online communities from February-April 2021. Overall, 2,044 individuals completed the survey and eligible participants were invited to complete follow-up survey from April-May 2023. Participants self-reported CGM use, insulin delivery method, HbA1c, impaired awareness of hypoglycemia (IAH), and SHE.
Results: Of 1,999 eligible individuals, 1,056 completed the follow-up survey and were eligible for analysis (53% response rate; mean age: 46 y; mean T1D duration: 29 y; 71% female; 97% White). Most reported using CGMs at baseline (91.8%) and follow-up (94.4%), and use of AID increased (baseline: 53.5%; follow-up: 69.0%; Table). At baseline, 61.7% reported HbA1c &lt;7% vs. 67.4% at follow-up. Rates of IAH and SHE in the prior year were similar at both time points.
Conclusion: Despite nearly universal CGM usage and increased adoption of AID, one-third of respondents did not achieve HbA1c targets and the proportion of respondents with IAH and SHE did not decline. These results highlight the need for innovative approaches to improve T1D care.

Disclosure
J.L. Sherr: Consultant; Medtronic. Advisory Panel; Medtronic, Insulet Corporation. Speaker's Bureau; Insulet Corporation. Advisory Panel; Vertex Pharmaceuticals Incorporated, MannKind Corporation, StartUp Health T1D Moonshot, Bigfoot Biomedical, Inc., Cecelia Health. Speaker's Bureau; Zealand Pharma A/S. K. Hagan: Employee; Vertex Pharmaceuticals Incorporated. R. Bhak: Employee; Vertex Pharmaceuticals Incorporated, Novartis Pharmaceuticals Corporation. M. Peter: None. H. Nguyen: None. C. Wang: Employee; Vertex Pharmaceuticals Incorporated. T. Pakalapati: None. J. Sherwood: Employee; Vertex Pharmaceuticals Incorporated. T. Gupta: Employee; Vertex Pharmaceuticals Incorporated. J.L. Gaglia: Consultant; Vertex Pharmaceuticals Incorporated. Stock/Shareholder; Vertex Pharmaceuticals Incorporated. Consultant; Avotres Inc., Imcyse, Diamyd Medical. E.M. Cornelius: None. K.S.M. Chapman: None. W. Wolf: None. J. Pettus: Consultant; Sanofi, Novo Nordisk, Diasome, Carmot Therapeutics, Inc., Kriya Therapeutics, Lilly Diabetes, Provention Bio, Inc.

Funding
Vertex Pharmaceuticals Incorporated
336-OR: Females Undergoing Islet Transplantation with CNI-Based Immunosuppression May Be at Higher Risk of Renal Function Decline
Authors: CARR ALICE L.J. , MARFIL-GARZA BRAULIO A. , LAM ANNA , ANDERSON BLAIRE L. , O'GORMAN DOUG , KIN TATSUYA , BIGAM DAVID , JAMES SHAPIRO A.M. , SENIOR PETER A. 
Published: July 2024

Islet transplantation (ITx) is an established treatment for recurrent, severe hypoglycemia in type 1 diabetes, however, requires lifelong immunosuppression (IS) which can be nephrotoxic. We conducted a risk regression to identify factors associated with progression to Stage 3 CKD (S3CKD) or worse post-ITx. We used data from adults undergoing ITx alone at the University of Alberta Hospital between March 11 1999 and Oct 1 2019 with &gt;1 year follow up. IS included tacrolimus and sirolimus/mycophenolate. We identified episodes of irreversible S3CKD as eGFR &lt;60 ml/min/1.73m2 for ≥90d in addition to a final 12m average eGFR below threshold. We conducted multivariable competing risk (death) regression with the covariates: baseline eGFR, age at first ITx, diabetes duration, total ITx count, mean tacrolimus trough levels in year 1 post-ITx, number of acute kidney injury (AKI) events in year 1 post-ITx, sex, baseline hypertension and sirolimus exposure. We identified 199 adults (41% M followed for a median 76.1m [IQR 38.0-131.6]), of which 47.7% progressed to S3CKD within a median 28m [IQR 9-57]. Female sex and more AKI events substantially increased the risk of progression to S3CKD (HR 1.50, [95% CI 1.31,1.80, p =0.004; HR 1.21, [95% CI 1.02, 1.45, p=0.028] respectively). Older age at first-ITx, lower baseline eGFR and longer diabetes duration had modest effect of significance on the risk of progression. Mean tacrolimus level in the first year post-ITx, number of ITx, baseline hypertension and exposure to sirolimus were not significant predictors for the risk of progression to S3CKD. No sex differences were found in risk for Stage 4 or 5 CKD. IS may put female ITx recipients at greater hazard of progressing to S3CKD, independently of other potential risk factors. Further study is required to elucidate this association, which could translate into sex-specific strategies to manage IS post-ITx. Effective IS regimens without nephrotoxicity remain an important goal.

Disclosure
A.L.J. Carr: None. B.A. Marfil-Garza: None. A. Lam: None. B.L. Anderson: None. D. O'Gorman: None. T. Kin: None. D. Bigam: None. A. Shapiro: Consultant; Vertex Pharmaceuticals Incorporated, Betalin Therapeutics, Hemostemix Inc, ViaCyte, Inc., Aspect Biosystems. P.A. Senior: Consultant; Abbott, Bayer Inc., Dexcom, Inc., Eli Lilly and Company, GlaxoSmithKline plc, Insulet Corporation, Novo Nordisk Canada Inc., Sanofi, Vertex Pharmaceuticals Incorporated. Speaker's Bureau; Abbott, Dexcom, Inc., Insulet Corporation, Novo Nordisk Canada Inc. Research Support; Novo Nordisk Canada Inc.
349-OR: Reduction of RNA-Editing Enzyme ADAR1 in Human Islets Triggers an Interferon Response and Impairs Beta-Cell Function
Authors: DAI CHUNHUA , SINGH AJAY K. , BRANTLEY REBEKAH , BRADLEY AMBER , JENKINS REGINA , SAUNDERS DIANE C. , BRISSOVA MARCELA , LEVANON EREZ , KLOCHENDLER AGNES , DOR YUVAL , POWERS ALVIN C. 
Published: July 2024

Introduction & Objective: It is thought that viral infection triggers islet inflammation, an interferon signature, and autoimmunity resulting in type 1 diabetes. Despite extensive research, an inciting virus has not been identified. We hypothesized that impaired RNA editing and accumulation of double-stranded RNA in beta cells triggers an interferon response, causing islet inflammation, autoimmunity, and beta cell destruction. While RNA editing regulated by adenosine deaminases acting on RNA (ADAR) has been studied in some organs and in cancer, little is known about the role of ADAR in human islets.
Method: To elucidate the role of ADAR1 in human islets, we first studied ADAR expression and distribution in human pancreas across postnatal developmental timeline (1 day, 4 months, 2, 6, 10, 35 years). Then we transduced human pseudoislets with a shRNA for ADAR and examined their function and gene expression. The transduced pseudoislets were also transplanted into NSG mice. Insulin secretion was measured and grafts were studied.
Results: We found that ADAR1 expression at all ages was greater in endocrine cells than acinar cells. Using the shRNA approach, ADAR mRNA levels were reduced by 70% (n=11 donors). After 7-day culture, expression of dsRNA sensors, IFNB1, IRF7, IRF9, and interferon-stimulated genes was increased while INS and MAFA expression was reduced in ADAR knockdown islets without changes in insulin secretion. However, 3 weeks post transplantation, glucose/arginine-stimulated human insulin secretion was significantly decreased in mice with the ADAR shRNA graft compared with scrambled shRNA control graft (0.117 vs 0.300 ng/mL, p=0.0001, n=3 donors). Analysis of pseudoislet grafts 4 weeks after transplantation showed marked accumulation of mouse CD45+ cells around ADAR-knockdown islet grafts.
Conclusion: Interruption of RNA editing in human islets activates the interferon signaling pathway leading to islet inflammation and beta cell dysfunction.

Disclosure
C. Dai: None. A.K. Singh: None. R. Brantley: None. A. Bradley: None. R. Jenkins: None. D.C. Saunders: None. M. Brissova: None. E. Levanon: Advisory Panel; ADARX, Exsilio. A. Klochendler: None. Y. Dor: None. A.C. Powers: None.
Physiotherapy Management in Spina Bifida Cases
Authors: Riantini Ni Putu , Rahayu Umi Budi , Waspada Edy 
Published: July 2024

Spina bifida or neural tube defect (NTD) is a spinal disorder that does not close completely, resulting in disability or developmental failure of the spinal cord. The cause of spina bifida has no definite reason, but there are several factors that are considered to increase the risk, namely folic acid deficiency, family history of spina bifida, and history of taking drugs. Patients with spina bifida will experience weakness in the lower extremity muscles, decreased ability to control urination, and decreased ability to carry out daily activities. The study used a case report study conducted at YPAC Surakarta for boys aged 15 years with spina bifida disorder. Physiotherapy plays a role in optimizing muscle strength, active movement of children, and improving functional abilities by using interventional stretching exercises, myofacial release, strengthening exercises, and a combination of Kegel Exercises and bridging exercises. After being treated for 6 times T1-T6 there was an increase in muscle strength as measured by manual muscle testing (MMT), changes in the range of motion of the joints (LGS) as measured by the goniometer, an increase in functional ability as measured by the Barthel Index.
Efektivitas Transcutaneous (TENS), Ultrasound (US) dan Terapi Latihan Pada Kondisi Carpal Tunnel Syndrome (CTS): Study Kasus
Authors: Qomariyah Qomariyah , Filmasari Fitri , Rania Ratu , Adelin Shafira Prajawati , Dianingtyas Ayu Sulistiani , Kinanti Dyah Kusuma Ayu , Herawati Isnaini , Wahyuni Wahyuni 
Published: July 2024

Latar Belakang: Carpal tunnel syndrome (CTS) adalah kondisi medis umum yang menyebabkan rasa sakit, mati rasa, dan kesemutan di tangan dan lengan pada pasien yang mengalami CTS. CTS terjadi ketika saraf median ditekan saat bergerak melalui pergelangan tangan. Faktor risiko untuk CTS termasuk obesitas, aktivitas pergelangan tangan yang monoton, kehamilan, keturunan genetik, dan peradangan reumatoid. Manifestasi klinis yang muncul berupa adanya nyeri, penurunan lingkup gerak sendi, penurunan kekuatan otot dan penurunan aktivitas fungsional. Intervensi untuk penanganan carpal tunnel syndrome dapat menggunakan transcutaneous electrical nerve (TENS), ultrasound (US), dan terapi latihan berupa strengthening.
Metode: Studi kasus tunggal dengan desain penelitian pre dan post test yaitu membandingkan antara penilaian sebelum dan sesudah intervensi TENS, Ultrasound dan terapi latihan berupa strengthening exercise kemudian diobservasi dan dievaluasi sebanyak 3 kali.
Hasil: Terjadi perubahan pada skala nyeri dengan NRS , kekuatan otot dengan MMT, dan kemampuan fungsional dengan Wrist Hand Disability Index (WHDI).
Kesimpulan: Studi kasus ini menyimpulkan bahwa intervensi fisioterapi berpengaruh pada nyeri, kekuatan otot dan kemampuan fungsional pada pasien CTS.

Full Text:
Physiotherapy Management of Total Knee Replacement et Causa Bilateral Genu Osteoarthritis
Authors: Reski Sri , Wahyuni Wahyuni , Widiatmi Sri 
Published: July 2024

Background: Total Knee Replacement (TKR) et causa Osteoarthritis genu bilateral is a medical procedure for replacing the knee joint with an artificial material in the form of a plate. Weight gain or obesity may be the most common cause of meniscus/joint-cushion thinning. This will cause pain and limited range of motion after knee joint replacement surgery. By providing physiotherapy interventions in the form of IR, Tens and Exercise therapy based on the Rehabilitation Protocol For Knee Replacement Surgery, it is hoped that pain and functional limitations in the knee can return to normal soon. Purpose: the aim is to determine the effect of providing physiotherapy interventions in the form of IR, Tens and Exercise therapy in increasing functional ability in conditions after Total Knee Replacement (TKR) and causing bilateral genu osteoarthritis. Methods: this program is carried out directly to respondents with post-Total Knee Replacement (TKR) conditions and causes of bilateral genu osteoarthritis by administering 3 times of therapy to obtain results of increased functional ability as measured by scores on the KOOS index, namely T0: 36.406 to T3: 39.554. Conclusion: the provision of physiotherapeutic interventions in the form of IR, Tens and Exercise therapy after the case of Total Knee Replacement (TKR) et causa osteoarthritis genu bilateral is proven to reduce complaints in the form of edema, pain, limited range of motion of the joints, and decreased muscle strength which has an impact on increasing the functional abilities of the respondents.
Differences between SNAGS and Mc Kenzie Interventions with Core Stability and Mc Kenzie on the Functional Ability of Elderly People with Lumbar HNP Conditions at Hermina Hospital Depok
Authors: Megawanty Irma , Maulina Luluk 
Published: July 2024

HNP is a degenerative disease where the elasticity of the annulus fibrosus decreases so that it becomes one of the causes of LBP and often occurs in the elderly. One of the roles of physiotherapy in HNP cases can be treated with exercise therapy, with the SNAGS and Mc Kenzie intervention methods as well as with Core Stability and Mc Kenzie. To help improve the functional abilities of the elderly. The purpose of the study is to determine the differences in interventions for Lumbar HNP cases using the SNAGS and Mc Kenzie methods as well as Core Stability and Mc Kenzie on the functional abilities of the elderly. The design of this study used a quasi-experimental with two groups pre-post test. A sample of 22 people was selected by purposive sampling which was divided into two, namely treatment 1 and treatment 2. The research was conducted for 4 weeks consisting of one pretest, with meetings twice a week with a duration of 30-45 minutes and one post-test. The instrument used is the ODI questionnaire. The result showed that the normality test using the Shapiro-Wilk test resulted in a value of p=0.000, which means it was significant in both treatment groups. From the results of the paired test, it is significant with a value of p = 0.000 meaning p <0.05. The reduction of the difference in the percentage of disability in treatment group 1 was -32.55 per cent, and in treatment group 2 was -37.27 per cent. The conclusion from the study is SNAGS and Mc Kenzie interventions as well as Core Stability and Mc Kenzie can affect the functional abilities of the elderly. With more effective results on Core stability and Mc Kenzie interventions in improving the functional abilities of the elderly with Lumbar HNP conditions.
Design Optimisation of a Truss-to-Column Connection in a Frame Structure Made of Round Tubes
Authors: Shchutsky S. V. , Limantsev A. A. , Skuratov S. V. , Levenets K. V. 
Published: July 2024

Introduction. The article investigates the ways to optimise the design of a truss-to-column connection in a frame structure made of round tubes. A steel lattice frame with a span of 66 m has been studied. A spanning member of a frame in the form of a truss transmits loads to a frame column through a rigid truss-to-column connection. In such structures, the maximum bending moments are applied to a truss-to-column connection, thus the problem of regulating its geometry is one of the objectives to be solved within the optimal designing. The aim of this paper is to create the most rational design solution for such a connection.Materials and Methods. In the lattice frames, depending on the chosen design, 5 to 7 members subject to compression stress converge at its inner side. The conventional variants of executing this connection would require using the heavy wall tubes which would result in the excess of material consumption. Within the research, modeling and calculation of various configurations of the truss-to-column connection were executed. The analysis of the calculation results revealed the shortcomings of the studied truss-to-column connection in a frame structure.Results. As a result of the connection design optimisation, a new configuration was suggested, where the connection of a bottom chord was executed by a slotted gusset plate. Such a solution allows for the most complete use of the bearing capacity of the bottom chord cross section.Discussion and Conclusion. As a result of the optimisation, the proposed design of a truss-to-column connection makes it possible to reduce the metal consumption while maintaining the relative simplicity of manufacture. At the same time, by reducing the local stresses, it is possible to achieve the greater strength and reliability of a truss-to-column connection.
Political-Legal Means of Ensuring the Institution of Electoral Democracy Development in Russia
Authors: Kuzina S. I. , Chapurko T. M. 
Published: July 2024

Introduction. At present, the Russian state is still undergoing the process of its social system transformation. The deterioration of the geopolitical situation has affected all spheres of state activity and has made the political, social and economic contradictions more acute. The electoral (vote-based) democracy is a category both social and political-legal. The institution of elections in the contemporary states becomes the focus of close attention due to capacity to involve a big amount of citizens into the social life. However, the process and final result of citizens' will expression is, to great extent, determined by the electoral system existing in the country. Legal scholars are very careful when referring to the issues of electoral system reform because in the countries with the transitional political systems of the late 20th century, the electoral institutions have developed intensely, but often inconsistently and without proper thinking. The aim of the present research is to reveal the weak points in the political-legal means of ensuring the electoral democracy development in Russia and propose the ways of reinforcing the political and ideological component in the electoral system of the country.Materials and Methods. The political and legal basis for ensuring the institutional development of electoral democracy in Russia was analysed in the article. The general scientific and specific scientific methods were used in the research, such as, the cognitive analysis of the electoral democracy essence, the analysis of the official legal documents that legally stipulate the categorial apparatus of the object of the research, i.e. electoral democracy, the sociological method of studying the public opinion regarding elections in the country, and others.Results. It has been proved that further institutionalisation of the vote-based or electoral democracy processes requires legal stipulation of the technological and socio-political innovations. Measures on improving the institution of electoral democracy in accordance with the social request of the Russian people have been proposed.Discussion and Conclusion. The problems of political and legal ensuring the institute of electoral democracy in the Russian Federation have been revealed. The state policy goals for improving the institution of electoral democracy within the sustainable development of Russia could be achieved through further accomplishment of the system of suffrage, reinforcement of the political and ideological component of the electoral system of the country.
Selection and Morphological Characterization of Crossed Anthurium (Anthurium andreanum) cv. Midori × Angel
Authors: Kurniati Ridho , Suryawati Suryawati , Supenti Supenti , Syafrina Riska 
Published: July 2024

The floriculture industries depend on market and consumer preferences which dynamically change. Innovation to create new varieties is one of the solutions. The breeding program enhances genetic variation and new varieties. One of the methods was conventional cross breeding. The research objective was to characterize and select the potential clones in the F1 population of crossing anthurium cv. Midori × Angel. Anthurium Midori as female parent and Anthurium cv. Angel as male parent. The individual selection method was used to select the F1 population of Anthurium cv. Midori × Angel. The observation parameters were spathe length (cm), spadix length and width (cm), total number of leaves, total number of shoots, total number of flowers, inflorescent length (cm), and plant height (cm). There were 26 individual offspring from the crossing Anthurium cv. Midori × Angel. Most of the offspring inherited from both the combination of Midori and Angel. They were greenish white. Green was from Midori and white was from Angel. MA-16 and MA-27 were selected as potential clones to be registered as new varieties. The character of these clones was green spathe inherited from Midori as female parent. Keywords: Clone, Leaf color, Leaf shape, Offspring, Varieties.
Analisis Asuhan Keperawatan Pada Pasien Efusi Pleura Dengan Gangguan Pemenuhan Kebutuhan Dasar Oksigenasi Menggunakan Intervensi Breathing Exercise
Authors: Nur Pratiwi Dian Khafifa , Patima  , Musdalifah  , Hasnah  
Published: July 2024

Latar Belakang : Kebutuhan dasar manusia adalah unsur-unsur yang dibutuhkan manusia dalam mempertahankan keseimbangan fisiologis maupun psikologis, yang bertujuan untuk mempertahankan kehidupan maupun Kesehatan. Kondisi sakit tertentu dapat menghambat proses oksigenasi dalam tubuh, Kondisi tersebut antara lain gangguan pada sistem pernapasan dan kardiovaskuler Salah satu penyakit yang terjadi pada paru-paru adalah efusi pleura. Dalam penanganan efusi pleura, terapi farmakologi saja tidak cukup untuk meredakan sesak pada beberapa pasien Salah satu terapi non farmakologi yang dikembangkan sekarang adalah breathing exercise dalam upaya menangani keluhan sesak napas pada pasien. Tujuan penelitian ini adalah untuk mengetahui gambaran Analisa Asuhan Keperawatan pada Klien Efusi Pleura dengan Gangguan Pemenuhan Kebutuhan Dasar Oksigenasi Menggunakan Intervensi Breathing Exercise Di RSUP Dr.Wahidin Sudirohusodo Makassar. Metode peneltiian yang digunakan adalah studi kasus dengan tehnik pengumpulan data melalui pemeriksaan fisik,wawancara dan observasi.Hasil : beberapa masalah keperawatan dapat teratasi, dan terdapat perubahan setelah pemberian intervensi keperawatan dilakukan Kesimpulan : pemberian intervensi breathing Exercise dapat membantu sesak napas klien dan mengoptimalkan kerja otot pernapasan, beberapa masalah keperawatan yang dirumuskan dapat teratasi