bluuebunny/crossref_metadata_2025_split huggingface dataset:
Keanekaragaman Jenis Ikan Di Perairan Pasang Surut Sungai Musi Kecamatan Muara Telang Kabupaten Banyuasin
Authors: Sofian  , Humairani  , Andrian Saputra  
Published: July 2024

Penelitian ini telah dilaksankan pada bulan April-Mei 2024 di kawasan irigasi perairan pasang surut sungai musi, Kecamatan Muara Telang, Kabupaten Banyuasin. Tujuan penelitian ini yaitu untuk mengevaluasi nilai indeks keanekaragaman jenis ikan yang hidup dikawasan irigasi perairan pasang surut sungai musi. Penelitian ini menggunakan metode purposive sampling dengan 3 stasiun pengamatan. Hasil penelitian menunjukkan bahwa pada stasiun 1 ditemukan sebanyak 74 individu yang terdiri atas 8 spesies dan 8 famili, pada stasiun 2 ditemukan sebanyak 51 individu yang tergolong kedalam 9 spesies dan 6 famili, sedangkan stasiun 3 terdapat 38 individu yang terdiri dari 7 spesies dan 7 famili. Secara keseluruhan, nilai total indeks keanekaragama jenis ikan dikawasan irigasi perairan pasang surut sungai musi yaitu sebesar 5,89 yang termasuk dalam kriteria tinggi.

This research was conducted on April-May 2024 in the tidal water irrigation area of ​​the Musi River, Muara Telang District, Banyuasin Regency. This study aims to analyze the fish diversity in the tidal irrigation area of ​​the Musi River. This research used the purposive sampling method with 3 observation stations. The results showed that as many as 74 individuals at station 1 consist of 8 species grouped in 8 families, at station 2 as much as 51 individuals consist of 9 species grouped in 8 families, and than at station 3 there were 38 individuals consist of 7 species grouped in 7 families. Overall, the fish diversity index value in the tidal water irrigation area of ​​the Musi River is 5.89, which are included in the high criteria diversity.
Karakterisasi Kimia dan Sensori Surimi di Perairan Tarakan
Authors: Nurhikma  , Serliana  , Diah Anggraini Wulandari  
Published: July 2024

Surimi adalah daging lumat yang terkonstrat dengan protein miofibril melalui proses pencucian berulang-ulang menggunakan air dingin yang terstandar dengan penambahan garam dan gula (Cryoprotectant). Tujuan penelitian ini adalah mengetahui kualitas surimi yang sesuai dengan Standar Nasional Indonesia dengan menggunakan tiga jenis ikan yang berbeda. Pengukuran kualitas surimi dilakukan dengan pengujian sifat dan kimia. Dalam penelitian dilakukan analisis rendemen surimi, pengujian kadar air, protein, lemak dan analisis sensori yang meliputi kenampakan, uji lipat dan uji gigit. Hasil penelitian menunjukkan rendemen surimi yang dihasilkan pada ikan barakuda 7,86, ikan gulamah 7,66 dan ikan bulan-bulan 7,26. Proksimat ikan segar yang dihasilkan ikan barakuda dengan kadar air 77,88%, protein 16,23%, lemak 6,67% dan abu 1,61%, gulamah dengan kadar air 79,41%, protein 15,58%, lemak 3,18% dan abu 1,56% sedangkan bulan-bulan kadar air 69,90%, protein 16,52%, lemak 4,18% dan abu 1,06%. Proksimat surimi yang dihasilkan adalah surimi barakuda kadar air 79,22%, protein 12,41% dan lemak 1,61%. Surimi gulamah memiliki kadar air 80,55%, protein 12,94% dan lemak 1,56% sedangakan surimi bulan-bulan kadar air 75,00%, protein 12,69%, dan lemak 1,06%. Sensori surimi ikan barakuda, ikan gulamah dan ikan bulan-bulan mencapai rata-rata 7 sampai 8. Karakterisasi kimia dan sensori surimi berbahan baku ikan pelagis (barakuda, gulamah dan bulan-bulan) di perairan tarakan sudah sesuai dengan SNI 2694:2013.

Surimi, a concentrated myofibril protein product, is prepared through repeated washing with cold water and the addition of salt and cryoprotectants. The objective is to evaluate the surimi quality based on the Indonesian National Standards (SNI 2694:2013). The assessment includes yield analysis, proximate composition (water, protein, fat, and ash content), and sensory evaluation (appearance, folding test, and bite test). The results indicate that the surimi yields were 7.86% for barracuda, 7.66% for gulamah, and 7.26% for moonfish. Fresh fish proximate analysis showed water contents of 77.88%, 79.41%, and 69.90%; protein contents of 16.23%, 15.58%, and 16.52%; fat contents of 6.67%, 3.18%, and 4.18%; and ash contents of 1.61%, 1.56%, and 1.06% for barracuda, gulamah, and moonfish, respectively. For surimi, the water contents were 79.22%, 80.55%, and 75.00%; protein contents were 12.41%, 12.94%, and 12.69%; and fat contents were 1.61%, 1.56%, and 1.06% for barracuda, gulamah, and moonfish, respectively. Sensory evaluation scores ranged from 7 to 8 for all three fish types. The study concludes that the surimi produced from barracuda, gulamah, and moonfish in Tarakan waters meets the quality standards outlined in SNI 2694:2013, showcasing promising chemical and sensory properties for these fish species.
Efficacy and selenium enrichment of Lycium barbarum in hydroponic and soil conditions in the Ararat valley
Authors: Babakhanyan Michael , Ghalachyan Laura , Chavushyan Vergine , Simonyan Karen , Darbinyan Lilit , Gulnazaryan Shushanik , Hovhannisyan Lusya 
Published: July 2024

Background: It is known that 60-80% of the population affected by various diseases, such as heart attack, stroke, and oncological diseases is associated with selenium (Se) deficiency. Therefore, enriching agricultural crops with Se is considered a current issue.
Objective: This study investigates Se enrichment of Lycium barbarum (Lb) and its effectiveness in hydroponic and soil conditions in the Ararat Valley. The research focuses on the impact of adding exogenous Se on plant productivity, Se accumulation, and the content of biologically active substances (BAS) in Lb berries and leaves.
Methods: The experiments were conducted from 2021 to 2023 using hydroponic and soil cultivation methods with varying Se concentrations in nutrient solutions and foliar nutrition.
Results: The results demonstrate that Se enrichment significantly increased Se and BAS levels in both leaves and berries of Lb, with hydroponic cultivation exhibiting higher accumulation compared to soil conditions. Foliar feeding with a 0.005% Se solution and exogenous Se addition to nutrient solutions at 1.0 mg/L resulted in notable improvements in Se content and plant productivity. Furthermore, the analyses revealed significant differences between hydroponically and soil-grown Lb, emphasizing the potential of hydroponic cultivation for producing Se-enriched plant material with enhanced BAS content.
Conclusion: Hydroponic cultivation supplemented with Se and foliar nutrition is recommended for obtaining Se-rich Lb plant material, which is suitable for medicinal and functional food purposes. These findings contribute to the development of biotechnologies for Se -enriched plant production and addressing health and nutritional needs.
Keywords: Goji, berries, biologically active substances, flavonoids, phenolic acids, tannins, carotenoids
Pengaruh Kepemimpinan Transformasional dan Iklim Organisasi Terhadap Kinerja Pegawai di Balai Besar Pengembangan Penjaminan Mutu Pendidikan Vokasi (BBPPMPV) Bisnis dan Pariwisata Bojongsari Depok
Authors: Edi Junaedi  , Waluyo  , Harjoyo  
Published: July 2024

ABSTRAK

Tujuan dari penelitian adalah mengetahui pengaruh kepemimpinan transformasional terhadap kinerja pegawai dan iklim organisasi terhadap kinerja pegawai serta mengetahui pengaruh kepemimpinan transformasional dan iklim organisasi secara simultan terhadap kinerja pegawai di Balai Besar Pengembangan Penjaminan Mutu Pendidikan Vokasi (BBPPMPV) Bisnis dan Pariwisata, Bojongsari Depok. Penelitian ini menggunakan metode kuantitatif untuk menentukan hubungan antar variabel dalam sebuah populasi. sampel penelitian sebanyak 65 orang dari total populasi 182 orang. Penarikan sampel dilakukan dengan menggunakan teknik penarikan stratified random sampling berdasarkan demografi responden. Demografi responden dalam penelitian ini meliputi jenis kelamin, usia, tingkat pendidikan, dan masa kerja. Faktor-faktor demografi tersebut dipandang berpengaruh terhadap kinerja yang menjadi topik penelitian ini. Hasil penelitian menunjukkan nilai Fhitung adalah 1014, 529 dengan signifikansi 0,000. Pengujian dengan membandingkan sig = 0,000 < α = 0,05, maka H0 ditolak, demikian juga pengujian melalui perbandingan nilai Fhitung = 1014,529. Ftabel = 3,140, juga menolak H0. Berdasarkan hasil pengujian tersebut, dapat disimpulkan bahwa secara bersama-sama terdapat pengaruh yang signifikan kepemimpinan transformasional dan iklim organisasi terhadap kinerja pegawai. Hasil ini juga menunjukkan bahwa model regresi telah sesuai untuk menjelaskan kinerja.

Kata kunci: kepemimpinan transformasional, iklim organisasi, kinerja
“To Make this Leap”: Understanding Relationships that Support Community College Students’ Transfer Journeys
Authors: W. Nahlik Beth E. , Hudson Tara D. , Nelson Lindsay 
Published: July 2024

For too many community college students, transferring to a four-year institution for a bachelor’s degree (i.e., vertical transfer) remains an unrealized aspiration. Prior research suggests that forms of capital can assist students in realizing their goals. Therefore, we sought to explore how relationships both within and outside of their institutions serve as sources of capital to support students’ vertical transfer journeys. Utilizing a qualitative research design, we applied Putnam’s (2000) two forms of social capital (bridging and bonding) and eight social support-related constructs from Moser’s (2013) expanded transfer student capital framework to data from focus groups and interviews with 33 pre- and post-transfer students. We found that participants actively constructed a patchwork of supportive relationships with both institutional agents and individuals external to the institution, which they utilized to search for, gather, and employ transfer capital. Our findings highlight that relationships outside of institutions are as crucial as relationships within the institution as sources of capital for vertical transfer students, suggesting a need to incorporate extra-institutional relationships into transfer capital frameworks and institutional initiatives to support transfer students. We also recommend institutions invest in programs designed to build students’ social and transfer capital.
Multimodal nature of pain syndrome in patients with rheumatoid arthritis in relation to the course of the disease and clinical characteristics
Authors: Zagretdinova K. R. , Gabdullina Z. N. , Sukhorukova E. V. , Zamanova E. S. , Abdrakipov R. Z. , Lapshina S. A. 
Published: July 2024

Purpose of the study. To evaluate the character of pain syndrome in patients with rheumatoid arthritis in correlation with the course of the disease and comorbid pathology.Material and methods. Sixty-six patients with a verified diagnosis of RA were examined. Of them 84.9% were women (n=56) and 15.1% men (n=10). The median age was 59 [52; 63] years. Disease activity was assessed by DAS28-CRP, with a median of 5.2 [4.54; 6.0]. Patients with moderate (31.8%) and high activity (57.5%) predominated. Disease duration averaged Me 156 [93; 246] months. Seropositive RA was suffered by 89.3% of patients. The distribution by radiological stage was as follows: 2 radiological stage – 36.3% (n=24), 3 radiological stage – 30.3% (n=20), 4 radiological stage – 33.4% (n=22). Baseline anti-inflammatory therapy was taken by 84.8% of patients (n=56), genetically engineered biological drugs were received by 28.7% (n=16). To assess the multicomponent nature of pain syndrome, the following were used: Pain Detect questionnaire — to verify neuropathic pain (NP), CSI questionnaire — to verify central sensitisation (CS). The EQ-5D-3L questionnaire was used to assess quality of life, and the Charlson index was used to assess comorbid pathology. Structural changes were assessed by modified Sharpe method on hand and foot radiographs, synovium vascularisation was assessed by joint ultrasound.Results. 84.8% of patients had pain syndrome of mixed nature. NP correlated with pain intensity by VAS (rSp=0.458, p<0.001), DAS28-CRP (rSp=0.509, p<0.001), number of peripheral arthritis (rSp=0, 414, p<0.001), number of comorbidities (rSp=0.337, p=0.006), Charlson index (rSp=0.323, p=0.009), EQ-5D-3L (rSp= –0.268, p=0.031). CS–with VAS pain intensity (rSp=0.250, p=0.045), DAS28-CRP (rSp=0.251, p=0.044), number of painful joints (rSp=0.353, p=0.004), number of comorbidities (rSp=0.368, p=0.003), BMI (rSp=0.266, p=0.032), systolic blood pressure level (rSp=0.403, p<0.001), number of erosions on hand and foot radiographs (rSp= –0.299, p=0.016), EQ-5D-3L (rCp= –0.408, p<0.001). Patients with the presence of synovial vascularization by ultrasound had three-component pain in more than half of cases, and the combination of inflammatory pain and CS did not occur in them.Conclusions. 84.8% of patients had multicomponent pain, with pain associated only with clinical parameters of disease activity. Associated pathology and local chronic inflammation in the joint potentiate the development of other types of pain and have a mutual negative influence.
Peculiarities of laboratory parameters dynamics during helicobacter pylori eradication in patients with rheumatoid arthritis
Authors: Aleksandrov V. A. , Zagorodneva E. A. , Aleksandrova N. V. , Cherkesova E. G. , Shilova L. N. , Aleksandrov A. V. 
Published: July 2024

Helicobacter pylori (H. pylori) is able to participate in the pathogenesis of a number of autoimmune diseases, actively maintains chronic inflammation and stimulates the systemic immune response. The virulence factor of H. pylori is cytotoxin-associated gene A (CagA) is associated with more severe inflammatory reactions, increased risk of poor clinical outcomes and is able to influence the efficacy of infection eradication in patients with rheumatoid arthritis (RA).Purpose of the study. To evaluate laboratory parameters of H. pylori eradication efficacy in RA patients with chronic infection with the strain encoding cytotoxin-associated gene A.Materials and methods. Forty women with RA and confirmed chronic H. pylori infection were included in the study (mean age 55.5±8.7 years; mean disease duration 13.9±9.1 years; DAS-28–3.96±0.56). CagA-IgG associated H. pylori infection was diagnosed in 22 (group I, CagA+) and not diagnosed in 18 (group II, CagA-) patients. All RA patients underwent a course of H. pylori eradication therapy.Results. The process of H. pylori eradication had the most significant effect on laboratory parameters of CagA-negative RA patients (group II). In this group the levels of rheumatoid factor (p=0,028), C-reactive protein (CRP, p=0.001), interleukin-6 (IL-6, p=0.002), tumor necrosis factor alpha (p=0,023), angiopoietinlike protein type 3 (p=0.026) and antibodies to cyclic citrullinated peptide (ACCP, p=0,016) decreased significantly. In patients from group I (CagA+) most parameters remained practically unchanged (p>0.05), except for CRP (p=0.01) and IL-6 (p=0.011). In the short term, the success of eradication in CagA+ patients was significantly lower than in CagA- patients (p=0.033). Moreover, confirmation of successful eradication of H. pylori within the established period of time was extremely rare (p=0.009) in the combination of CagA+ and high titers of ACCP and antibodies to modified citrullinated vimentin.Conclusions. The effectiveness of H. pylori eradication in RA patients depends on the presence of chronic infection with the strain encoding the cytotoxin-associated gene A and the level of antibodies to citrullinated proteins, which should be taken into account when choosing the therapeutic effect on H. pylori in this group.
Development of a synthetic library of humanized nanobodies for targeted IL-6 inhibition
Authors: Wang Lei , Dong Jiayi , Wu Chenlu , Yan Chenyue , Bi Chong , Xu Chengnan , Wu Yiling , Zheng Wenyun , Ma Xingyuan 
Published: July 2024

Interleukin-6 (IL-6) is a cytokine that can bind to IL-6 receptor and induce pleiotropic effects. It serves as a critical biomarker, involved in inflammation amplification, tumor progression, and many other disease developments. Nanobodies, featuring small structure and high affinity, are a powerful and versatile tool in medical diagnostics and therapeutics. Here, based on a scaffold optimized for humanization and stability, we developed a synthetic phage display library that rapidly generated high-affinity and humanized nanobodies, negating the need for animal immunization. Using enhanced green fluorescent protein (eGFP) as a benchmark, we demonstrated that the library produced humanized nanobodies with high function and great intracellular stability. The library was then subjected to screening against IL-6. We identified a standout nanobody, NbL3, which exhibited high affinity (22.16 nM) and stability and significantly inhibited IL-6-enhanced migration on the human breast cancer cell MCF-7 at a relatively low concentration. NbL3’s strong blocking activity provides a promising therapeutic alternative for the IL-6-targeted intervention strategy, underscoring the broader potential of our synthetic library as a versatile platform for the development of humanized nanobodies against multiple antigens.
Characteristics and pathogenicity of Vibrio alginolyticus SWS causing high mortality in mud crab (Scylla serrata) aquaculture in Hong Kong
Authors: Kwok Carsten Tsun-Ka , Yu Ray Chun-Wai , Hau Pak-Ting , Cheung Karry Yuen-Ching , Ng Iain Chi-Fung , Fung Joshua , Wong Ivan Tak-Fai , Yau Miranda Chong-Yee , Liu Wai-Man , Kong Hang-Kin , Siu Gilman Kit-Hang , Chow Franklin Wang-Ngai , Seto Sai-Wang 
Published: July 2024

IntroductionVibrio alginolyticus is a Gram-negative, rod-shaped bacterium belonging to the family of Vibrionaceae, a common pathogen in aquaculture animals, However, studies on its impact on Scylla serrata (mud crabs) are limited. In this study, we isolated V. alginolyticus SWS from dead mud crab during a disease outbreak in a Hong Kong aquaculture farm, which caused up to 70% mortality during summer.MethodsExperimental infection and histopathology were used to investigate the pathogenicity of V. alginolyticus SWS in S. serrata and validate Koch’s postulates. Comprehensive whole-genome analysis and phylogenetic analysis antimicrobial susceptibility testing, and biochemical characterization were also performed. ResultsOur findings showed that V. alginolyticus SWS caused high mortality (75%) in S. serrata with infected individuals exhibiting inactivity, loss of appetite, decolored and darkened hepatopancreas, gills, and opaque muscle in the claw. Histopathological analysis revealed tissue damage and degeneration in the hepatopancreas, gills, and claw muscle suggesting direct and indirect impacts of V. alginolyticus SWS infection.ConclusionsThis study provides a comprehensive characterization of V. alginolyticus SWS as an emerging pathogen in S. serrata aquaculture. Our findings underscore the importance of ongoing surveillance, early detection, and the development of targeted disease management strategies to mitigate the economic impact of vibriosis outbreaks in mud crab aquaculture.
Improving image quality and in-stent restenosis diagnosis with high-resolution “double-low” coronary CT angiography in patients after percutaneous coronary intervention
Authors: Wu Wenjie , Zhan Hefeng , Wang Yiran , Ma Xueyan , Hou Jiameng , Ren Lichen , Liu Jie , Wang Luotong , Zhang Yonggao 
Published: July 2024

ObjectiveThis study aims to investigate the image quality of a high-resolution, low-dose coronary CT angiography (CCTA) with deep learning image reconstruction (DLIR) and second-generation motion correction algorithms, namely, SnapShot Freeze 2 (SSF2) algorithm, and its diagnostic accuracy for in-stent restenosis (ISR) in patients after percutaneous coronary intervention (PCI), in comparison with standard-dose CCTA with high-definition mode reconstructed by adaptive statistical iterative reconstruction Veo algorithm (ASIR-V) and the first-generation motion correction algorithm, namely, SnapShot Freeze 1 (SSF1).MethodsPatients after PCI and suspected of having ISR scheduled for high-resolution CCTA (randomly for 100 kVp low-dose CCTA or 120 kVp standard-dose) and invasive coronary angiography (ICA) were prospectively enrolled in this study. After the basic information pairing, a total of 105 patients were divided into the LD group (60 patients underwent 100 kVp low-dose CCTA reconstructed with DLIR and SSF2) and the SD group (45 patients underwent 120 kVp standard-dose CCTA reconstructed with ASIR-V and SSF1). Radiation and contrast medium doses, objective image quality including CT value, image noise (standard deviation), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) for the aorta, left main artery (LMA), left ascending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA) of the two groups were compared. A five-point scoring system was used for the overall image quality and stent appearance evaluation. Binary ISR was defined as an in-stent neointimal proliferation with diameter stenosis ≥50% to assess the diagnostic performance between the LD group and SD group with ICA as the standard reference.ResultsThe LD group achieved better objective and subjective image quality than that of the SD group even with 39.1% radiation dose reduction and 28.0% contrast media reduction. The LD group improved the diagnostic accuracy for coronary ISR to 94.2% from the 83.8% of the SD group on the stent level and decreased the ratio of false-positive cases by 19.2%.ConclusionCompared with standard-dose CCTA with ASIR-V and SSF1, the high-resolution, low-dose CCTA with DLIR and SSF2 reconstruction algorithms further improves the image quality and diagnostic performance for coronary ISR at 39.1% radiation dose reduction and 28.0% contrast dose reduction.
Adherence to optimal medical therapy and control of cardiovascular risk factors in patients after ST elevation myocardial infarction in Mexico
Authors: Villalobos-Pedroza Montserrat , Hernandez-Pastrana Sarai , Arias-Mendoza Alexandra , Latapi-Ruiz Esparza Ximena , Robles-Ledesma Mariana , Guerrero-Ochoa Alejandra , Milanes-Gonzalez Nelson Antonio , Solis-Jimenez Fabio , Sierra Gonzalez-De Cossio Alejandro , Flores-Batres Alejandro Pablo , Brindis-Aranda Arielle Astrid , Rivera-Pedrote Edgar , Jara-Nevarez Alejandra , Gonzalez-Macedo Eder , Gopar-Nieto Rodrigo , Gonzalez-Pacheco Héctor , Briseño-De la Cruz Jose Luis , Araiza-Garaygordobil Diego 
Published: July 2024

IntroductionIn developing countries, there is a notable scarcity of real-world data on adherence to optimal medical therapy (OMT) and its correlation with major cardiovascular adverse events (MACEs) after ST-elevation myocardial infarction (STEMI). Our study focuses on addressing this gap by evaluating adherence to OMT, examining its influence on the risk of MACEs after STEMI, and assessing subsequent cardiovascular risk factor control in Mexico.MethodsWe conducted a prospective observational study of post-STEMI patients after hospital discharge. Adherence to treatment was assessed over a median of 683 days (interquartile range: 478–833) using the Simplified Medication Adherence Questionnaire (SMAQ). Patients were followed up for 4.5 years to monitor MACEs (cardiovascular death, cardiogenic shock, recurrent myocardial infarction, and heart failure).ResultsWe included 349 patients with a mean age of 58.08 years (±10.9), predominantly male (89.9%). Hypertension (42.4%), smoking (34.3%), type 2 diabetes mellitus (31.2%), obesity (22.92%), and dyslipidemia (21.4%) were highly prevalent. Adherence to OMT per SMAQ was 44.7%. The baseline clinical characteristics of adherent and non-adherent patients did not significantly differ. OMT prescription rates were as follows: acetylsalicylic acid, 91.1%; P2Y12 inhibitors, 76.5%; and high-intensity statins, 86.6%. While non-adherent patients had a numerically higher rate of MACEs (73 vs. 49 first events), there was no statistically significant difference (hazard ratio 1.30, 95% confidence interval 0.90–1.88).DiscussionIn this real-world study of patients after STEMI, we observed low adherence to OMT, a low proportion of global cardiovascular risk factor control, and a numerically higher incidence of recurrent major adverse cardiovascular events in non-adherent patients. Strategies to improve adherence to OMT and risk factor control are needed.