bluuebunny/crossref_metadata_2025_split huggingface dataset:
A population genomics insight into the Mediterranean origins of wine yeast domestication
Authors: Almeida Pedro , Barbosa Raquel , Zalar Polona , Imanishi Yumi , Shimizu Kiminori , Turchetti Benedetta , Legras Jean‐Luc , Serra Marta , Dequin Sylvie , Couloux Arnaud , Guy Julie , Bensasson Douda , Gonçalves Paula , Sampaio José Paulo 
Published: August 2015

AbstractThe domestication of the wine yeast Saccharomyces cerevisiae is thought to be contemporary with the development and expansion of viticulture along the Mediterranean basin. Until now, the unavailability of wild lineages prevented the identification of the closest wild relatives of wine yeasts. Here, we enlarge the collection of natural lineages and employ whole‐genome data of oak‐associated wild isolates to study a balanced number of anthropic and natural S. cerevisiae strains. We identified industrial variants and new geographically delimited populations, including a novel Mediterranean oak population. This population is the closest relative of the wine lineage as shown by a weak population structure and further supported by genomewide population analyses. A coalescent model considering partial isolation with asymmetrical migration, mostly from the wild group into the Wine group, and population growth, was found to be best supported by the data. Importantly, divergence time estimates between the two populations agree with historical evidence for winemaking. We show that three horizontally transmitted regions, previously described to contain genes relevant to wine fermentation, are present in the Wine group but not in the Mediterranean oak group. This represents a major discontinuity between the two populations and is likely to denote a domestication fingerprint in wine yeasts. Taken together, these results indicate that Mediterranean oaks harbour the wild genetic stock of domesticated wine yeasts.
Economic evaluations of interventions to manage hyperphosphataemia in adult haemodialysis patients: A systematic review
Authors: Rizk Rana , Hiligsmann Mickaël , Karavetian Mirey , Evers Silvia MAA 
Published: August 2015

AbstractManaging hyperphosphataemia in haemodialysis patients is resource‐intensive. A search for cost‐effective interventions in this field is needed to inform decisions on the allocation of healthcare resources. NHSEED, MEDLINE, EMBASE and CINAHL were searched for full economic evaluations of hyperphosphataemia‐managing interventions in adult haemodialysis patients, published between 2004 and 2014, in English, French, Dutch or German. Incremental cost‐effectiveness ratios of the interventions were up‐rated to 2013US$ using Purchasing Power Parity conversion rates and Consumer Price Indices. The quality of included studies was assessed using the Extended Consensus on Health Economic Criteria List. Twelve out of the 1681 retrieved records fulfilled the inclusion criteria. They reported only on one aspect of hyperphosphataemia management, which is the use of phosphate binders (calcium‐based and calcium‐free, in first‐line and sequential use). No economic evaluations of other phosphorus‐lowering interventions were found. The included articles derived from five countries and most of them were funded by pharmaceutical companies. The incremental cost‐effectiveness ratios of phosphate binders ranged between US$11 461 and US$157 760 per quality‐adjusted life‐year gained. Calcium‐based binders (especially calcium acetate) appear to be the optimal cost‐effective first‐ and second‐line therapy in prevalent patients, while the calcium‐free binder, lanthanum carbonate, might provide good value for money, as second‐line therapy, in incident patients. The studies' overall quality was suboptimal. Drawing firm conclusions was not possible due to the quality heterogeneity and inconsistent results. Future high‐quality economic evaluations are needed to confirm the findings of this review and to address other interventions to manage hyperphosphataemia in this population.
Model–data synthesis for the next generation of forest free‐air CO2 enrichment (FACE) experiments
Authors: Norby Richard J. , De Kauwe Martin G. , Domingues Tomas F. , Duursma Remko A. , Ellsworth David S. , Goll Daniel S. , Lapola David M. , Luus Kristina A. , MacKenzie A. Rob , Medlyn Belinda E. , Pavlick Ryan , Rammig Anja , Smith Benjamin , Thomas Rick , Thonicke Kirsten , Walker Anthony P. , Yang Xiaojuan , Zaehle Sönke 
Published: August 2015

SummaryThe first generation of forest free‐air CO2 enrichment (FACE) experiments has successfully provided deeper understanding about how forests respond to an increasing CO2 concentration in the atmosphere. Located in aggrading stands in the temperate zone, they have provided a strong foundation for testing critical assumptions in terrestrial biosphere models that are being used to project future interactions between forest productivity and the atmosphere, despite the limited inference space of these experiments with regards to the range of global ecosystems. Now, a new generation of FACE experiments in mature forests in different biomes and over a wide range of climate space and biodiversity will significantly expand the inference space. These new experiments are: EucFACE in a mature Eucalyptus stand on highly weathered soil in subtropical Australia; AmazonFACE in a highly diverse, primary rainforest in Brazil; BIFoR‐FACE in a 150‐yr‐old deciduous woodland stand in central England; and SwedFACE proposed in a hemiboreal, Pinus sylvestris stand in Sweden. We now have a unique opportunity to initiate a model–data interaction as an integral part of experimental design and to address a set of cross‐site science questions on topics including responses of mature forests; interactions with temperature, water stress, and phosphorus limitation; and the influence of biodiversity.
A survey of practice patterns in the use of laryngeal mask by pediatric anesthesiologists
Authors: Patel Anuradha , Clark Scott R. , Schiffmiller Moshe , Schoenberg Catherine , Tewfik George 
Published: August 2015

SummaryBackgroundLaryngeal mask is frequently the airway device of choice in routine general anesthesia for many procedures in children. Several studies have described the use of laryngeal masks in unconventional situations. This survey was undertaken to assess how laryngeal masks are being used by pediatric anesthesiologists.MethodThe 40‐question electronic survey using SurveyMonkey™ was sent to 2740 members of the Society for Pediatric Anesthesia (SPA). This survey assessed the age, work environment, types of practice, and training levels, as well as clinical situations in which the practitioners use laryngeal masks across different pediatric age groups.ResultsSeven hundred and forty‐three (27.1%) responses were obtained. The use of laryngeal mask increased as the patient age increased in nearly every queried situation. The practitioners routinely utilize laryngeal masks in a variety of challenging scenarios, such as in patients with a recent upper respiratory infection, in the difficult airway, remote locations, and long‐duration surgeries. A small percentage of pediatric anesthesiologists use laryngeal masks in laparoscopic surgery and prone position procedures.ConclusionPediatric anesthesiologists are using laryngeal masks in both routine and challenging/unconventional situations. Although many of the uses for laryngeal masks are not explicitly stated in the manufacturer guidelines, literature and current practice support the use of laryngeal masks in several of these scenarios.
Plant‐produced viral bovine vaccines: what happened during the last 10 years?
Authors: Ruiz Vanesa , Mozgovoj Marina V. , Dus Santos María José , Wigdorovitz Andrés 
Published: August 2015

SummaryVaccination has proved to be an efficient strategy to deal with viral infections in both human and animal species. However, protection of cattle against viral infections is still a major concern in veterinary science. During the last two decades, the development of efficient plant‐based expression strategies for recombinant proteins prompted the application of this methodology for veterinary vaccine purposes. The main goals of viral bovine vaccines are to improve the health and welfare of cattle and increase the production of livestock, in a cost‐effective manner. This review explores some of the more prominent recent advances in plant‐made viral bovine vaccines against foot‐and‐mouth disease virus (FMDV), bovine rotavirus (BRV), bovine viral diarrhoea virus (BVDV), bluetongue virus (BTV) and bovine papillomavirus (BPV), some of which are considered to be the most important viral causative agents of economic loss in cattle production.
Genome‐wide identification and in silico characterisation of microRNAs, their targets and processing pathway genes in Phaseolus vulgaris L.
Authors: de Sousa Cardoso T. C. , Portilho L. G. , de Oliveira C. L. , McKeown P. C. , Maluf W. R. , Gomes L. A. A. , Teixeira T. A. , do Amaral L. R. , Spillane C. , de Souza Gomes M. 
Published: August 2015

AbstractCommon bean (Phaseolus vulgaris L., Fabaceae) is a globally important staple crop, which is an important source of calories, protein and essential micronutrients. At the genomic level little is known regarding the small non‐coding RNAs within the common bean genome. One of the most important classes of such small non‐coding RNAs is microRNAs (miRNAs), which control mRNA and protein expression levels in many eukaryotes. Computational methods have been applied to identify putative miRNAs in the genomes of different organisms. In this study, our objective was to comprehensively identify and characterise miRNAs from the genome and transcriptome of P. vulgaris, including both mature and precursor miRNA forms. We also sought to identify the putative proteins involved in miRNA processing and the likely target genes of common bean miRNAs. We identified 221 mature miRNAs and 136 precursor miRNAs distributed across 52 different miRNA families in the P. vulgaris genome. Amongst these, we distinguished 129 novel mature miRNAs and 123 miRNA precursors belonging to 24 different miRNA families. We also identified 31 proteins predicted to participate in the miRNA‐processing pathway in P. vulgaris. Finally, we also identified 483 predicted miRNA targets, including many which corroborate results from other species, suggesting that miRNA regulatory systems are evolutionarily conserved and important for plant development. Our results expand the study of miRNAs and their target genes in common bean, and provide new opportunities to understand their roles in the biology of this important staple crop.
Molecules, morphology and Mimeoma scarabs: evolutionary and taxonomic implications for a palm‐associated scarab group
Authors: MOORE MATTHEW R. , BEZA‐BEZA CRISTIAN F. , WICKELL DAVID A. , BECK JAMES B. , JAMESON MARY L. 
Published: August 2015

AbstractCyclocephaline scarabs, the second largest tribe of rhinoceros beetles, are important pollinators of early‐diverging angiosperm families in the tropics. The evolutionary history of cyclocephaline genera is poorly resolved and several genera are thought to be nonmonophyletic. We assess the monophyly of Mimeoma Casey, a group of Neotropical palm‐feeding scarabs, and its relationship to Cyclocephala with a phylogenetic analysis of 2899 bp of DNA sequence data and 18 morphological characters. All five species of Mimeoma were included in analyses along with species of Cyclocephala Dejean, Dyscinetus Harold and Tomarus Erichson as outgroup taxa. Nearly complete 28S, 12S and CO1 data were collected from 26 of 29 specimens, of which 16 samples were pinned, museum specimens. 28S data strongly support a nonmonophyletic Mimeoma; mitochondrial data (CO1 and 12S) suggest that Mimeoma species are nested within an apical clade of other Cyclocephala species; combined molecular and morphological data identify two strongly supported clades of Mimeoma species but do not support their sister relationship. Combined data show that Mimeoma species are nested within Cyclocephala, thus rendering Cyclocephala paraphyletic. Mimeoma is synonymized within Cyclocephala resulting in the following new combinations: Cyclocephala acuta Arrow n.comb., Cyclocephala englemani (Ratcliffe) n.comb., Cyclocephala maculata Burmeister n.comb., Cyclocephala nigra (Endrödi) n.comb. and Cyclocephala signatoides Höhne n.comb. Our results demonstrate that pinned, museum specimens can be used to obtain DNA sequence data (particularly high‐copy gene regions) for evolutionary studies, and provide the first empirical support that host‐plant associations within cyclocephaline scarab clades are conserved at the plant family‐level.
Hyperspectral Remote Sensing Classifications: A Perspective Survey
Authors: Chutia D , Bhattacharyya D K , Sarma K K , Kalita R , Sudhakar S 
Published: August 2015

AbstractClassification of hyperspectral remote sensing data is more challenging than multispectral remote sensing data because of the enormous amount of information available in the many spectral bands. During the last few decades, significant efforts have been made to investigate the effectiveness of the traditional multispectral classification approaches on hyperspectral data. Formerly extensively established conventional classification methods have been dominated by the advanced classification approaches and many pre‐processing techniques have been developed and incorporated in hyperspectral classification. A perspective survey of hyperspectral remote sensing classification approaches is presented here. It comprehensively highlights the taxonomy of major classification approaches reported during the last two decades and describes an experimental evaluation of a few major classification algorithms. Recent advancements in the development of classification approaches are also emphasized with a set of guidelines for achieving better classification performances.
Experience with anidulafungin in patients with allogeneic hematopoietic stem cell transplantation and graft‐versus‐host disease
Authors: Yáñez L. , Insunza A. , Ibarrondo P. , de Miguel C. , Bermúdez A. , Colorado M. , López‐Duarte M. , Richard C. , Conde E. 
Published: August 2015

AbstractBackgroundIt is well known that both acute and chronic graft‐versus‐host disease (GVHD) are associated with invasive fungal disease (IFD). Because the galactomannan antigen diagnostic test has low specificity and sensitivity outside of the neutropenic period, many institutions use posaconazole or voriconazole for IFD prophylaxis during GVHD treatment. Moreover, several factors, mainly hepatic impairment, can limit the use of extended spectrum azoles, both in prophylaxis or treatment.MethodsWe retrospectively analyzed 25 patients with allogeneic hematopoietic stem cell transplantation (HSCT) and GVHD – grade III–IV acute GHVD (n = 15), progressive chronic GVHD (n = 7), and “overlap” GVHD (n = 3) – who received intravenous anidulafungin (200 mg on day 1, followed by 100 mg once daily). If necessary, anidulafungin treatment was followed by oral administration of 200 mg voriconazole twice a day or 200 mg posaconazole 3 times daily until patients were considered not at risk for IFD.ResultsTwenty‐one patients (85%) received anidulafungin as prophylaxis and 5 patients (15%) received it as treatment. Median duration of intravenous anidulafungin administration was 8 days (range 6–17). Seven patients (28%) presented mild adverse effects, with no significant interactions with calcineurin inhibitors. Sequentially, 4 patients received voriconazole and 6 posaconazole. Two patients (8%) developed IFD after anidulafungin withdrawal: 1 with Candida albicans and the other with Mucor, 8 and 5 days after withdrawal, respectively.ConclusionsOur results are of interest owing to the absence of data in the literature on anidulafungin use in HSCT patients with GVHD, and suggest that anidulafungin, because of its spectrum, pharmacological profile, low toxicity, and absence of interactions with immunosuppressants, could be a drug of choice in this setting.
Diagnostic performance of fluorescent light‐emitting diode microscopy for tuberculous lymphadenitis in a high‐burden setting
Authors: Abdissa Ketema , Tadesse Mulualem , Abdella Kedir , Bekele Alemayehu , Bezabih Mesele , Abebe Gemeda 
Published: August 2015

AbstractObjectiveDiagnosis of tuberculous lymphadenitis using fine‐needle aspiration cytology is a simple and safe but low‐specificity method, whereas conventional smear microscopy has variable sensitivity due to low bacterial load. We evaluated the diagnostic performance of fluorescent light‐emitting diode (LED) microscopy on routinely collected fine‐needle aspirates from tuberculous lymphadenitis presumptive cases.MethodsFine‐needle aspirates were collected from patients clinically suspected of having tuberculous lymphadenitis as part of routine diagnosis. Smear preparation was performed from the aspirate and processed for cytology, conventional Ziehl–Neelsen and LED microscopy. The remaining aspirate was processed for culture on Lowenstein–Jensen media. Capilia TB‐Neo test was used to differentiate M. tuberculosis complex from non‐tuberculous mycobacteria.ResultA total of 144 tuberculous lymphadenitis presumptive cases were included. 66.7% (96/144) were positive for M. tuberculosis complex on culture. Only one isolate was identified as non‐tuberculous mycobacteria. The detection rates of Ziehl–Neelsen and LED microscopy were 18.8% (27/144) and 34% (49/144), respectively. As compared to culture, sensitivity was 25.0% [95% CI: 16.3–33.7] for Ziehl–Neelsen microscopy and 45.8% [95% CI: 35.9–55.8] for LED microscopy. The specificity was 93.8% [95% CI: 86.9–100] for Ziehl–Neelsen microscopy and 89.6% [95% CI: 80.9–98.2] for LED microscopy. LED microscopy showed a statistically significant increase in sensitivity and similar specificity compared to Ziehl–Neelsen microscopy. Mean reading time of positive slides was 2.62 min/slide for Ziehl–Neelsen and 1.60 min/slide for LED microscopy. Cytology showed sensitivity of 82.3% and specificity of 54.2%. LED microscopy detected TB bacilli in 33.3% of cases cytologically classified as suppurative abscess.ConclusionThe LED microscopy for tuberculous lymphadenitis had significantly higher sensitivity and shorter screening time than Ziehl–Neelsen microscopy. Use of LED microscopy among cases classified as suppurative abscess on fine‐needle aspirate cytology improves evidence‐based diagnosis of presumptive tuberculous lymphadenitis cases. Moreover, LED microscopy could be considered as an alternative approach in settings where fine‐needle aspirate cytology is impractical.
Oral glucocorticoid pulse therapy for induction of treatment of canine pemphigus foliaceus – a comparative study
Authors: Bizikova Petra , Olivry Thierry 
Published: August 2015

BackgroundThe management of canine pemphigus foliaceus (PF) often requires long‐term immunosuppressive treatment that is often associated with unacceptable adverse effects. High‐dose glucocorticoid pulse therapy, an alternative protocole used for pemphigus in people, has been shown to provide rapid improvement in dogs with pemphigus foliaceus and vulgaris.ObjectivesTo further identify the benefit of pulse therapy for management of canine PF, we compared the outcomes of oral glucocorticoid pulse and traditional therapies during the first 3 months of disease management.AnimalsDogs were allocated based on their oral glucocorticoid regimen during the first 12 weeks of PF management into the ‘traditional’ (20 dogs) or the ‘pulse’ (18 dogs) treatment groups.ResultsThe proportion of dogs achieving complete remission (CR) during the first 12 weeks of treatment was significantly higher for the ‘pulse’ (61%) than for the ‘traditional’ group (15%; P = 0.0063). The maximal oral glucocorticoid dosage given to dogs from the ‘traditional’ group was significantly higher (median: 3.2 mg/kg) than that given between pulses to dogs from the other group (median: 1.1 mg/kg; P < 0.0001). There was no significant difference between groups in the time needed to achieve CR, the proportion of dogs requiring adjuvant immunosuppressive treatment or in the proportion of dogs experiencing severe adverse drug reactions.Conclusions and clinical importanceThese results suggest several benefits associated with oral glucocorticoid pulse therapy, such as a higher proportion of dogs achieving CR during the first 3 months, a lower average maximal oral glucocorticoid dosage given between pulses and minimal adverse drug events.
Outcome of Donor Cats After Unilateral Nephrectomy as Part of a Clinical Kidney Transplant Program
Authors: Danielson Kelson C. , Hardie Robert J. , McAnulty Jonathan F. 
Published: August 2015

ObjectiveTo compare 1) complications between 2 ureteral harvest techniques (ureteral papilla harvest [UPH] and ureteral transection [UT]); 2) to investigate the prevalence of kidney failure in a population of kidney donors; and 3) to evaluate owner satisfaction with commercially sourced cats adopted after kidney donation.Study DesignRetrospective case series.AnimalsCats (n = 72) that had unilateral nephrectomy for kidney donation.MethodsMedical records were reviewed and information on short‐ and long‐term complications and evidence of kidney failure was recorded. Clients were interviewed by telephone to ascertain their satisfaction with the adopted donor cats as pets.ResultsSeventy‐two cats had unilateral nephrectomy. Forty‐two owners were able to be contacted for survey data. Twenty‐eight cats had complete medical records including serum BUN, creatinine, and urine specific gravity. For these 28 cats, mean age at nephrectomy was 1.9 years (median, 1.1 years; range, 0.5–9.3 years) and mean age at follow‐up was 6.8 years (median, 5.1 years; range, 1.0–18.7 years). There was no difference in major or minor complication rates between UPH and UT techniques. Kidney failure occurred in 17.8% of cats. All owners were satisfied with the adopted donor cats, which were obtained from commercial facilities.ConclusionsUPH is a safe technique in cats being used for kidney donation. Commercially sourced cats make suitable pets after kidney donation. The prevalence of kidney failure in the donor population appears to be higher than that in the general population, but definitive conclusions cannot be made based on this study. Further, prospective study is needed to identify the true prevalence of kidney failure in cats after unilateral nephrectomy.
Adverbial relative clauses in world Englishes
Authors: SUÁREZ‐GÓMEZ CRISTINA 
Published: August 2015

ABSTRACTThis paper investigates adverbial relative clauses in world Englishes, in particular relative clauses expressing place (the place where), time (the time when), manner (the way in which) and reason (the reason why). Using data from the ICE corpora, it compares the varieties spoken in India, Hong‐Kong and Singapore. In particular we consider: (i) the meaning expressed by the relative clause; (ii) the nominal antecedent, both its meaning and form; and (iii) the relative word used to introduce the relative clause (adverbial relative word,wh‐ pronoun,thatand zero). An examination of these issues reveals distinguishing features in the distribution of relative words that are related to the different constructions, to the specific postcolonial varieties that have been developed in the different countries and, finally, to the interaction between the superstrate and the different substrate languages.
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
Authors: Goedert Michel 
Published: August 2015

Converging paradigms in neurodegeneration
Parkinson's disease and Alzheimer's disease are progressive neurodegenerative diseases with increasing prevalence in our aging populations. Recent evidence suggests that some of the molecular mechanisms involved in the pathology of these diseases have similarities to those observed in infectious prion diseases such as bovine spongiform encephalopathy (mad cow disease). Goedert reviews how the spread of a variety of pathological protein aggregates is involved in neurodegenerative disease.

Science
, this issue p.
10.1126/science.1255555