bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychophysical Evaluation of Haptic Perception Under Augmentation by a Handheld Device
Authors: Wu Bing , Klatzky Roberta , Lee Randy , Shivaprabhu Vikas , Galeotti John , Siegel Mel , Schuman Joel S. , Hollis Ralph , Stetten George 
Published: September 2014

Objective: This study investigated the effectiveness of force augmentation in haptic perception tasks. Background: Considerable engineering effort has been devoted to developing force augmented reality (AR) systems to assist users in delicate procedures like microsurgery. In contrast, far less has been done to characterize the behavioral outcomes of these systems, and no research has systematically examined the impact of sensory and perceptual processes on force augmentation effectiveness. Method: Using a handheld force magnifier as an exemplar haptic AR, we conducted three experiments to characterize its utility in the perception of force and stiffness. Experiments 1 and 2 measured, respectively, the user’s ability to detect and differentiate weak force (<0.5 N) with or without the assistance of the device and compared it to direct perception. Experiment 3 examined the perception of stiffness through the force augmentation. Results: The user’s ability to detect and differentiate small forces was significantly improved by augmentation at both threshold and suprathreshold levels. The augmentation also enhanced stiffness perception. However, although perception of augmented forces matches that of the physical equivalent for weak forces, it falls off with increasing intensity. Conclusion: The loss in the effectiveness reflects the nature of sensory and perceptual processing. Such perceptual limitations should be taken into consideration in the design and development of haptic AR systems to maximize utility. Application: The findings provide useful information for building effective haptic AR systems, particularly for use in microsurgery.
Exploring Relationships of Human-Automation Interaction Consequences on Pilots
Authors: Durso Francis T. , Stearman Eric J. , Morrow Daniel G. , Mosier Kathleen L. , Fischer Ute , Pop Vlad L. , Feigh Karen M. 
Published: September 2014

Objective: We attempted to understand the latent structure underlying the systems pilots use to operate in situations involving human-automation interaction (HAI). Background: HAI is an important characteristic of many modern work situations. Of course, the cognitive subsystems are not immediately apparent by observing a functioning system, but correlations between variables may reveal important relations. Method: The current report examined pilot judgments of 11 HAI dimensions (e.g., Workload, Task Management, Stress/Nervousness, Monitoring Automation, and Cross-Checking Automation) across 48 scenarios that required airline pilots to interact with automation on the flight deck. Results: We found three major clusters of the dimensions identifying subsystems on the flight deck: a workload subsystem, a management subsystem, and an awareness subsystem. Discussion: Relationships characterized by simple correlations cohered in ways that suggested underlying subsystems consistent with those that had previously been theorized. Application: Understanding the relationship among dimensions affecting HAI is an important aspect in determining how a new piece of automation designed to affect one dimension will affect other dimensions as well.
Correction of Protruding Ears (Weerda Grade I Deformity) Using Knotless Bidirectional Barbed Absorbable Sutures
Authors: Taboada‐Suárez Antonio , Brea‐García Beatriz , Couto‐González Ivan , Vila‐Moriente José Luís 
Published: September 2014

ObjectiveTo introduce a variant of the Furnas technique using a knotless bidirectional barbed absorbable suture for the correction of Weerda grade I prominent ears.Study DesignComparative study between groups of patients and literature review.SettingTertiary care teaching hospital.Subjects and MethodsReview of 25 patients who underwent otoplasty by the technique described by Furnas and 23 patients who underwent otoplasty by this modified technique using knotless bidirectional barbed absorbable sutures. Postoperative complications and level of satisfaction were measured.ResultsThe postoperative complication rate was low regardless of the suture technique used. We observed statistical significance in relation to the pain caused by the suture knots (P <. 001). The reoperation rate was on the limit of statistical significance (P =. 051). In the group with bidirectional barbed absorbable sutures, no reoperation was required. In the group with classic sutures, reoperation was necessary in 5 cases to correct recurrence and in 1 case to correct asymmetry. Furthermore, in 4 cases of this group, sutures were removed due to pain or extrusion. The overall long‐term satisfaction rate was 91.6% in the group operated with classic suture techniques and 95.7% in the group operated with knotless bidirectional barbed absorbable sutures.ConclusionThe use of knotless bidirectional barbed absorbable sutures in the Furnas technique is simple and fast and presents few complications. The major advantages that we obtained with the use of this technique were the absence of discomfort caused by the type of suture and the fact that no reoperation was required to correct relapses.
Effects of neuromuscular electrical stimulation and low-level laser therapy on the muscle architecture and functional capacity in elderly patients with knee osteoarthritis: a randomized controlled trial
Authors: Melo Mônica de Oliveira , Pompeo Klauber Dalcero , Brodt Guilherme Auler , Baroni Bruno Manfredini , da Silva Junior Danton Pereira , Vaz Marco Aurélio 
Published: September 2014

Objectives: To determine the effects of low-level laser therapy in combination with neuromuscular electrical stimulation on the muscle architecture and functional capacity of elderly patients with knee osteoarthritis. Design: A randomized, evaluator-blinded clinical trial with sequential allocation of patients to three different treatment groups. Setting: Exercise Research Laboratory. Subjects: A total of 45 elderly females with knee osteoarthritis, 2-4 osteoarthritis degrees, aged 66–75 years. Intervention: Participants were randomized into one of the following three intervention groups: electrical stimulation group (18–32 minutes of pulsed current, stimulation frequency of 80 Hz, pulse duration of 200 μs and stimulation intensity fixed near the maximal tolerated), laser group (low-level laser therapy dose of 4–6 J per point, six points at the knee joint) or combined group (electrical stimulation and low-level laser therapy). All groups underwent a four-week control period (without intervention) followed by an eight-week intervention period. Main measures: The muscle thickness, pennation angle and fascicle length were assessed by ultrasonography, and the functional capacity was assessed using the 6-minute walk test and the Timed Up and Go Test. Results: After intervention, only the electrical stimulation and combined groups exhibited significant increases in the muscle thickness (27%–29%) and pennation angle (24%–34%) values. The three groups exhibited increased performance on the walk test (5%–9%). However, no significant differences in terms of functional improvements were observed between the groups. Conclusions: Neuromuscular electrical stimulation reduced the deleterious effects of osteoarthritis on the quadriceps structure. Low-level laser therapy did not potentiate the effects of electrical stimulation on the evaluated parameters.
A new technique of in vivo synchrotron radiation coronary microangiography in the rat
Authors: Sakamoto Hiroaki , Matsushita Shonosuke , Hyodo Kazuyuki , Tokunaga Chiho , Sato Fujio , Hiramatsu Yuji 
Published: September 2014

Background Previously, in our laboratory, synchrotron radiation coronary microangiography (SRCA) using Langendorff-perfused rat hearts could visualize a coronary artery of 50 µm in diameter. However, in vivo rat SRCA poses the problem of compromised temporal resolution due to the rapid heart rate of rats. Purpose To establish a simple method of in vivo rat SRCA with bradycardia induced by intravenous injection of adenosine triphosphate disodium hydrate (ATP). Material and Methods SRCA was performed at the Photon Factory of the High Energy Accelerator Research Organization (Tsukuba, Japan). Eight male Wistar rats were anesthetized. A catheter for injecting the contrast material was inserted into the carotid artery. Temporary bradycardia was induced by an intravenous bolus injection of 5 mg of ATP, and SRCA was performed immediately thereafter. Results After ATP administration, the average heart rate decreased from 388 to 73 beats per minute. As a result, we could detect a coronary artery as small as 45 µm in diameter. Conclusion Our SRCA system which has a high resolution of 9 µm per pixel could detect a coronary artery as small as 45 µm in diameter in the in vivo rat.
Stenting for Emergency Colorectal Obstruction: An Analysis of 204 Patients in Relation to Predictors of Failure and Complications
Authors: Köhler G. , Antoniou S. A. , Lechner M. , Mayer F. , Mair J. , Emmanuel K. 
Published: September 2014

Background and Aims: Self-expanding metallic stents are increasingly used in the management of malignant and benign colorectal obstructions. We aimed to identify relevant predictive factors for stent failure and stent-related complications. Material and Methods: We conducted a retrospective single-center analysis of 204 consecutive patients who underwent emergency colorectal stenting procedures because of symptomatic bowel obstructions from 1996 to 2011 at the Sisters of Charity Hospital Linz, Austria. Results: A total of 204 patients (median age 74 years) with 36 (17.7%) benign and 168 (82.3%) malignant obstructions were included in the study. Technical success was achieved in 92.5% and clinical success in 86.8% of the cases. Major complications occurred in 2.9% and minor ones in 19.6%. Overall mortality during a median follow-up period of 4.3 years was 73% (149 patients). Relevant predictors of increased risk of complications were extracolonic obstruction (p = 0.001), complete obstruction (p = 0.066), and inflammatory bowel disease (p = 0.05). Stent localization at the splenic flexure, a stenosis of >8 cm in length, and the need for endoscopic guidance were associated with higher rates of technical and/or clinical stenting failure. Conclusion: Colorectal stenting is less invasive than other means of emergency treatment for large bowel obstruction; it is generally safe and effective in different types of colorectal obstruction. However, relevant rates of failure and complications were recorded and predictors could be determined.
Experiences of Nursing Staff Using Dementia-Specific Case Conferences in Nursing Homes
Authors: Holle Daniela , Krüger Cornelia , Halek Margareta , Sirsch Erika , Bartholomeyczik Sabine 
Published: September 2014

Background: Dementia specific-case conferences with the Innovative dementia oriented assessment tool (CC-IdA) could be an important tool with which to analyze and manage challenging behavior. The study gives an insight into nursing staff' experiences using CC-IdA in dementia care. Methods: Qualitative interviews were conducted with 18 nursing teams from 12 nursing homes alongside a quasi-experimental study. In addition, observational field notes were taken. Interviews and observational field notes were analyzed using the thematic content analysis. Results: CC-IdA contributed to a reflective handling of challenging behavior, to changes in the communication with residents and to the identification of potentially triggers of challenging behavior. Factors influencing the implementation of CC-IdA were among others a lack of moderation skills, limited knowledge of dementia, a lack of biographical information and a lack of involvement by other professionals. Conclusions: CC-IdA represents an important tool in the management of challenging behavior of people with dementia. For the successful implementation of these case conferences, both structural and personal resources are needed.
A less invasive distal osteotomy of the radius for malunited dorsally displaced extra-articular fractures
Authors: Fok M. W. M. , Fernandez D. L. , Rivera Y. L. Hernandez 
Published: September 2014

A less invasive corrective osteotomy for symptomatic post-traumatic deformity of the distal radius was done in 12 patients. They were followed up for an average of 3.7 years. The indications for correction were based on the patients’ level of activities, pain, functional limitations, loss of grip strength or deformity occurring with an extra-articular rotational malunion of the distal end of the radius. The procedure included a dorsal open wedge osteotomy through a dorsal incision in which the fulcrum of rotation, or hinge, was located at the palmar cortex, and stabilized with an extra- and intramedullary fixed angle device. The bone defect was replaced with autologous morsellized iliac bone graft. The final outcome was graded as very good in eight patients, good in two and fair in two. Level of evidence: IV
A Novel Test for IGT Utilizing Metabolite Markers of Glucose Tolerance
Authors: Cobb Jeff , Eckhart Andrea , Perichon Regis , Wulff Jacob , Mitchell Matthew , Adam Klaus-Peter , Wolfert Robert , Button Eric , Lawton Kay , Elverson Robert , Carr Bernadette , Sinnott Margaret , Ferrannini Ele 
Published: September 2014

Background: The oral glucose tolerance test (OGTT) is the only method to diagnose patients having impaired glucose tolerance (IGT), but its use has diminished considerably in recent years. Metabolomic profiling studies have identified a number of metabolites whose fasting levels are associated with dysglycemia and type 2 diabetes. These metabolites may serve as the basis of an alternative test for IGT. Method: Using the stable isotope dilution technique, quantitative assays were developed for 23 candidate biomarker metabolites. These metabolites were measured in fasting plasma samples taken just prior to an OGTT from 1623 nondiabetic subjects: 955 from the Relationship between Insulin Sensitivity and Cardiovascular Disease Study (RISC Study; 11.7% IGT) and 668 subjects from the Diabetes Mellitus and Vascular Health Initiative (DMVhi) cohort from the DEXLIFE project (11.8% IGT). The associations between metabolites, anthropometric, and metabolic parameters and 2hPG values were assessed by Pearson correlation coefficients and Random Forest classification analysis to rank variables for their ability to distinguish IGT from normal glucose tolerance (NGT). Multivariate logistic regression models for estimating risk of IGT were developed and evaluated using AUCs calculated from the corresponding ROC curves. Results: A model based on the fasting plasma levels of glucose, α-hydroxybutyric acid, β-hydroxybutyric acid, 4-methyl-2-oxopentanoic acid, linoleoylglycerophosphocholine, oleic acid, serine and vitamin B5 was optimized in the RISC cohort (AUC = 0.82) and validated in the DMVhi cohort (AUC = 0.83). Conclusions: A novel, all-metabolite-based test is shown to be a discriminate marker of IGT. It requires only a single fasted blood draw and may serve as a more convenient surrogate for the OGTT or as a means of identifying subjects likely to be IGT.
Review of Lacrosse-Related Musculoskeletal Injuries in High School and Collegiate Players
Authors: Vincent Heather K. , Zdziarski Laura Ann , Vincent Kevin R. 
Published: September 2014

Context: Participation in lacrosse has dramatically increased since 2001. Changes in the game rules, sport equipment, and athlete characteristics have all contributed to the injury patterns in lacrosse over time. Objective: A summary of lacrosse-related musculoskeletal injuries. Data Sources: Medline, CINAHL, Scopus, and Web of Science were searched for articles relating to the epidemiology and mechanisms of lacrosse injuries in high school and collegiate lacrosse players. Study Selection: The search strategy used the following keywords: lacrosse, injury, musculoskeletal, high school, intercollegiate, knee, shoulder, fracture, ankle, foot, concussion, and surveillance. Studies were included if they reported injury risk, injury type, or injury mechanism in high school or collegiate lacrosse players. Study Design: Systematic review. Level of Evidence: Level 4. Data extraction: Injury type, frequency, and mechanism as well as population were extracted. Results: Thirteen cohort studies and an additional 15 case series and reports were included. For all lacrosse players, ankle, knee, and hand/wrist were key sites for acute injury. Among collegiate players, preseasonal play elicits more injuries than seasonal play. Female players incur more noncontact and overuse injuries than male players. Boys have 3 to 5 times the risk for sustaining a fracture compared with girls in competition and practice. Women experienced fewer concussions but more facial fractures than men. Injuries to the foot/ankle, head, face, and wrist/hand more often required surgery in girls than in boys. Conclusion: Male players incur more injuries than female players. However, because of the collisional nature of play, more shoulder, arm, and upper leg injuries occur in male players. Fractures to the head and hand occur relatively more frequently in female players. Injury risk can be modified with appropriate training regimens and by respecting the game rules.
Predictors of Postoperative Cognitive Decline in Very Old Patients With Hip Fracture
Authors: Luger Markus F. , Müller Stephan , Kammerlander Christian , Gosch Markus , Luger Thomas J. 
Published: September 2014

Background: To investigate incidence and predictors of the various postoperative cognitive declines in old patients with hip fracture. Methods: This retrospective chart study evaluated 411 patients (age ≥80 years, follow-up 5 years). After exclusion of 82 patients (preexisting dementia or delirium), 70 patients showing either diagnosed postoperative delirium (POD; group 1; N = 18, 5.5%) or an unspecified cognitive dysfunction and behavior (group 2; N = 52, 15.8%) were analyzed and compared with those without any acute postoperative cerebral impairment (control group; N = 259, 78.7%). Medical history, anesthesiological, orthopedic, and rehabilitation data were assessed using the medical database of the hospital information system. Relative ratio was calculated with Fisher exact test: P value Bonferroni corrected ≤.003. Results: Acute cognitive complications were observed in 70 (21.3%) patients. Our data in group 1 showed that patients with a medical history of stroke (relative risk [RR] = 16.2, P = .0001) or nicotine abuse (RR = 14.4, P = .001) and perioperative surgical bleeding (RR = 6.54, P = .002) are more likely to develop POD. Unspecified cognitive dysfunction and behavior (group 2) was significantly associated with a medical history of stroke (RR = 12.5, P = .0001) and postoperatively with depression (RR = 3.32, P = .001). In the follow-up, significantly more patients in group 1 (55.6%, RR = 21.8, P = .0001) and group 2 (13.5%, RR = 3.88, P = .001) developed dementia as compared to controls (1.9%). Mortality did not differ significantly between the groups (group 1: RR = 1.75, P = .5 and group 2: RR = 0.66, P = 1.0). Conclusion: These data show that various predictors can identify a greater likelihood of developing postoperative cognitive decline in very old patients with hip fracture. Not identifying or labeling of POD limits the opportunity for evaluation, treatment, and planning. Thus, routine cognitive assessments need to be performed in the scope of multidisciplinary orthogeriatric comanagement.
Smoking Cessation Related to Improved Patient-Reported Pain Scores Following Spinal Care in Geriatric Patients
Authors: Behrend Caleb , Schonbach Etienne , Coombs Andre , Coyne Ellen , Prasarn Mark , Rechtine Glenn 
Published: September 2014

Introduction: We examined rates of smoking cessation and the effect of smoking cessation on pain and disability scores in a geriatric patient population. Methods: Prospectively maintained database records of 6779 patients treated for painful spinal disorders were examined. The mean duration of care was 8 months. Multivariate statistical analysis was performed with independent variables including smoking status, secondary gain status, gender, treatment type, depression, and age. Results: Of the patients seeking care for painful spinal disorders, 8.9% over the age of 55 smoked compared with 23.9% of those under 55 years of age. Rates of smoking cessation did not differ for those older than 55 years (25.1%) and younger patients (26.1%). Current smokers in both age-groups reported greater pain than those who had never smoked in all pain ratings ( P < .001). Mean improvement in reported pain over the course of treatment was significantly different in nonsmokers and current smokers in both age-groups ( P < .001). Those who quit smoking during the course of care reported greater improvement in pain than those who continued to smoke. The mean improvement in pain ratings was clinically significant in patients in all 3 groups of nonsmokers whereas those who continued to smoke had no clinically significant improvement in reported pain. Conclusion: The results support the need for smoking cessation programs, given a strong association between improved patient-reported pain and smoking cessation. Fewer older patients smoke but they are equally likely to quit.
The splenic autoimmune response to ADAMTS13 in thrombotic thrombocytopenic purpura contains recurrent antigen-binding CDR3 motifs
Authors: Schaller Monica , Vogel Monique , Kentouche Karim , Lämmle Bernhard , Kremer Hovinga Johanna A. 
Published: September 2014

Key Points
The spleen harbors ADAMTS13-specific memory B cells following acute acquired TTP. The splenic anti-ADAMTS13 antibody repertoire is characterized by a set of unique and novel CDR3 motifs, 4 shared by 2 patients.
Recombinant long-acting glycoPEGylated factor IX in hemophilia B: a multinational randomized phase 3 trial
Authors: Collins Peter W. , Young Guy , Knobe Karin , Karim Faraizah Abdul , Angchaisuksiri Pantep , Banner Claus , Gürsel Türkiz , Mahlangu Johnny , Matsushita Tadashi , Mauser-Bunschoten Eveline P. , Oldenburg Johannes , Walsh Christopher E. , Negrier Claude 
Published: September 2014

Key PointsNonacog beta pegol, a recombinant glycoPEGylated FIX with extended half-life, was developed to improve care for patients with hemophilia B. Weekly prophylaxis with nonacog beta pegol was well tolerated and was associated with low bleeding rates and an improved quality of life.