bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Tissue Integrated Tissue‐Engineered Trachea Regeneration Based on 3D Printed Bioelastomer Scaffolds
Authors: Song Xingqi , Zhang Peiling , Luo Bin , Li Ke , Liu Yu , Wang Sinan , Wang Qianyi , Huang Jinyi , Qin Xiaohong , Zhang Yixin , Zhou Guangdong , Lei Dong 
Published: August 2024

AbstractFunctional segmental trachea reconstruction is a critical concern in thoracic surgery, and tissue‐engineered trachea (TET) holds promise as a potential solution. However, current TET falls short in fully restoring physiological function due to the lack of the intricate multi‐tissue structure found in natural trachea. In this research, a multi‐tissue integrated tissue‐engineered trachea (MI‐TET) is successfully developed by orderly assembling various cells (chondrocytes, fibroblasts and epithelial cells) on 3D‐printed PGS bioelastomer scaffolds. The MI‐TET closely resembles the complex structures of natural trachea and achieves the integrated regeneration of four essential tracheal components: C‐shaped cartilage ring, O‐shaped vascularized fiber ring, axial fiber bundle, and airway epithelium. Overall, the MI‐TET demonstrates highly similar multi‐tissue structures and physiological functions to natural trachea, showing promise for future clinical advancements in functional TETs.
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5
Authors: Zhang Qian , Zhang Chunlin , Kang Changjiang , Zhu Jiaran , He Qingshan , Li Hongwei , Tong Qiang , Wang Min , Zhang Linlin , Xiong Xin , Wang Yuren , Qu Hua , Zheng Hongting , Zheng Yi 
Published: August 2024

AbstractNon‐healing diabetic wounds and ulcer complications, with persistent cell dysfunction and obstructed cellular processes, are leading causes of disability and death in patients with diabetes. Currently, there is a lack of guideline‐recommended hypoglycemic drugs in clinical practice, likely due to limited research and unclear mechanisms. In this study, it is demonstrated that liraglutide significantly accelerates wound closure in diabetic mouse models (db/db mice and streptozotocin‐induced mice) by improving re‐epithelialization, collagen deposition, and extracellular matrix remodeling, and enhancing the proliferation, migration, and adhesion functions of keratinocytes. However, these effects of improved healing by liraglutide are abrogated in dedicator of cytokinesis 5 (Dock5) keratinocyte‐specific knockout mice. Mechanistically, liraglutide induces cellular function through stabilization of unconventional myosin 1c (Myo1c). Liraglutide directly binds to Myo1c at arginine 93, enhancing the Myo1c/Dock5 interaction by targeting Dock5 promoter and thus promoting the proliferation, migration, and adhesion of keratinocytes. Therefore, this study provides insights into liraglutide biology and suggests it may be an effective treatment for diabetic patients with wound‐healing pathologies.
Bidirectional Phase Transformations in Multi‐Principal Element Alloys: Mechanisms, Physics, and Mechanical Property Implications
Authors: Sun Jiayi , Li Heqing , Chen Yujie , An Xianghai 
Published: August 2024

AbstractThe emergence of multi‐principal element alloys (MPEAs) heralds a transformative shift in the design of high‐performance alloys. Their ingrained chemical complexities endow them with exceptional mechanical and functional properties, along with unparalleled microscopic plastic mechanisms, sparking widespread research interest within and beyond the metallurgy community. In this overview, a unique yet prevalent mechanistic process in the renowned FeMnCoCrNi‐based MPEAs is focused on: the dynamic bidirectional phase transformation involving the forward transformation from a face‐centered‐cubic (FCC) matrix into a hexagonal‐close‐packed (HCP) phase and the reverse HCP‐to‐FCC transformation. The light is shed on the fundamental physical mechanisms and atomistic pathways of this intriguing dual‐phase transformation. The paramount material parameter of intrinsic negative stacking fault energy in MPEAs and the crucial external factors c, furnishing thermodynamic, and kinetic impetus to trigger bidirectional transformation‐induced plasticity (B‐TRIP) mechanisms， are thorougly devled into. Furthermore, the profound significance of the distinct B‐TRIP behavior in shaping mechanical properties and creating specialized microstructures c to harness superior material characteristics is underscored. Additionally, critical insights are offered into key challenges and future striving directions for comprehensively advancing the B‐TRIP mechanism and the mechanistic design of next‐generation high‐performing MPEAs.
Amorphous Hydrated Tungsten Oxides with Enhanced Pseudocapacitive Contribution for Aqueous Zinc‐Ion Electrochromic Energy Storage
Authors: Zhuang Dongsheng , Zhang Zhixuan , Weng Jingbo , Wang Junyi , Zhang Hongliang , Cheng Wei 
Published: August 2024

AbstractTungsten oxides suffer from sluggish ion diffusion kinetics, limited ion storage capacity, and inadequate stability within the aqueous zinc ion electrolyte, thereby constraining their applicability in electrochromic energy storage devices (EESDs). Here, the amorphous hydrated tungsten oxide films with large optical modulation, fast response speed, large capacity, and high cycling stability are reported, enabled by tuning the contents of structural water and adjusting the pH value of aqueous zinc ion electrolyte. The enhancement of the electrochromic and ion storage performance is mainly due to the introduction of structural water which triggers pseudocapacitive behavior dominated by surface redox reaction, resulting in high electrochemical activity and fast electrochemical kinetics. Meanwhile, the relatively low pH value ensures the chemical stability of the hydrated tungsten oxide film, in synergy with surface redox that avoids ion trapping, leading to extraordinary cycling stability of up to 13000 cycles, marking the state‐of‐the‐art stability for tungsten oxide‐based materials in aqueous electrolyte. Based on the hydrated tungsten oxide films, high‐capacity and stable large‐size EESDs are constructed with the capability of visually monitoring energy status, recovering energy, and regulating light. This work provides a simple yet effective strategy for enhancing the performance of tungsten oxide‐based aqueous zinc ion EESDs.
A novel model for tracking copolymerization kinetics: Sequence structure quality evaluation
Authors: Zhang Si‐Qi , Zhou Yin‐Ning , Jin Jie , Luo Zheng‐Hong 
Published: August 2024

AbstractPrecise control over sequence structure in copolymers is essential for chemical product engineering. The complexity of sequence structures results in the challenging characterization of monomer sequences. Herein, a chemical composition model (CD model) is developed to record the distribution density of monomers in the chain segment, where the deviation of the chemical composition function between a copolymer and its ideal sequence structure can directly map the sequence structure quality. The application of the CD model in randomly generated virtual copolymers demonstrates that the model has great sensitivity and discrimination to evaluate sequence structures accurately. Furthermore, the CD model is combined with the kinetic Monte Carlo algorithm to explicitly track the evolution of sequence structure quality in the copolymerization process. The CD model provides an insight into the evolution of sequence structure, which is conducive to building the bridge between molecular structure and properties for the development of chemical product engineering.
Global characteristics and outcomes of autologous hematopoietic stem cell transplantation for newly diagnosed multiple myeloma: A study of the worldwide network for blood and marrow transplantation (WBMT)
Authors: Garderet Laurent , Gras Luuk , Koster Linda , Baaij Laurien , Hamad Nada , Dsouza Anita , Estrada‐Merly Noel , Hari Parameswaran , Saber Wael , Cowan Andrew J. , Iida Minako , Okamoto Shinichiro , Takamatsu Hiroyuki , Mizuno Shohei , Kawamura Koji , Kodera Yoshihisa , Ko Bor‐Sheng , Liam Christopher , Ho Kim Wah , Goh A. Sim , Tan S. Keat , Elhaddad Alaa M. , Bazarbachi Ali , Chaudhry Qamar un Nisa , Alfar Rozan , Bekadja Mohamed‐Amine , Benakli Malek , Ortiz Cristobal Augusto Frutos , Riva Eloisa , Galeano Sebastian , Bass Francisca , Mian Hira S. , McCurdy Arleigh , Wang Feng Rong , Meng Ly , Neumann Daniel , Koh Mickey , Snowden John A. , Schönland Stefan , McLornan Donal P. , Hayden Patrick John , Sureda Anna , Greinix Hildegard T. , Aljurf Mahmoud , Atsuta Yoshiko , Niederwieser Dietger 
Published: August 2024

AbstractAutologous hematopoietic cell transplantation (AHCT) is a commonly used treatment in multiple myeloma (MM). However, real‐world global demographic and outcome data are scarce. We collected data on baseline characteristics and outcomes from 61 725 patients with newly diagnosed MM who underwent upfront AHCT between 2013 and 2017 from nine national/international registries. The primary endpoint was overall survival (OS), and the secondary endpoints were progression‐free survival (PFS), relapse incidence (RI) and non‐relapse mortality (NRM). Median OS amounted to 90.2 months (95% CI 88.2–93.6) and median PFS 36.5 months (95% CI 36.1–37.0). At 24 months, cumulative RI was 33% (95% CI 32.5%–33.4%) and NRM was 2.5% (95% CI 2.3%–2.6%). In the multivariate analysis, superior outcomes were associated with younger age, IgG subtype, complete hematological response at auto‐HCT, Karnofsky score of 100%, international staging scoring (ISS) stage 1, HCT‐comorbidity index (CI) 0, standard cytogenetic risk, auto‐HCT in recent years, and use of lenalidomide maintenance. There were differences in the baseline characteristics and outcomes between registries. While the NRM was 1%–3% at 12 months worldwide, the OS at 36 months was 69%–84%, RI at 12 months was 12%–24% and PFS at 36 months was 43%–63%. The variability in these outcomes is attributable to differences in patient and disease characteristics as well as the use of maintenance and macroeconomic factors. In conclusion, worldwide data indicate that AHCT in MM is a safe and effective therapy with an NRM of 1%–3% with considerable regional differences in OS, PFS, RI, and patient characteristics. Maintenance treatment post‐AHCT had a beneficial effect on OS.
Exploring the Impact of Ring Mobility on the Macroscopic Properties of Doubly Threaded Slide‐Ring Gel Networks
Authors: Oh Jongwon , Liu Guancen , Kim Hojin , Hertzog Jerald E. , Nitta Natsumi , Rowan Stuart J. 
Published: August 2024

AbstractThe integration of mechanically interlocked molecules (MIMs) into polymeric materials has led to the development of mechanically interlocked polymers (MIPs). One class of MIPs that have gained attention in recent years are slide‐ring gels (SRGs), which are generally accessed by crosslinking rings on a main‐chain polyrotaxane. The mobility of the interlocked crosslinking moieties along the polymer backbone imparts enhanced properties onto these networks. An alternative synthetic approach to SRGs is to use a doubly threaded ring as the crosslinking moiety, yielding doubly threaded slide‐ring gel networks (dt‐SRGs). In this study, a photo‐curable ligand‐containing thread was used to assemble a series of metal‐templated pseudo[3]rotaxane crosslinkers that allow access to polymer networks that contain doubly threaded interlocked rings. The physicochemical and mechanical properties of these dt‐SRGs with varying size of the ring crosslinking moieties were investigated and compared to an entangled gel (EG) prepared by polymerizing the metal complex of the photo‐curable ligand‐containing thread, and a corresponding covalent gel (CG). Relative to the EG and CG, the dt‐SRGs exhibit enhanced swelling behavior, viscoelastic properties, and stress relaxation characteristics. In addition, the macroscopic properties of dt‐SRGs could be altered by “locking” ring mobility in the structure through remetalation, highlighting the impact of the mobility of the crosslinks.
Enantio‐ and Regioconvergent Nickel‐Catalyzed Etherification of Phenols by Allylation to Access Chiral C(sp3)−O Allyl Aryl Ethers
Authors: Brösamlen Daniel , Neb Daniel , Oestreich Martin 
Published: August 2024

AbstractAn enantio‐ and regioconvergent allylation of phenols under nickel catalysis with an α‐/γ‐regioisomeric mixture of racemic silylated/germylated allylic chlorides is reported. The silyl/germyl group governs the regioselectivity, and the transformation affords enantiomerically enriched unsymmetrical 1,3‐disubstituted allyl aryl ethers with excellent regiocontrol in good yields and excellent enantioselectivities. Notably, no nickel‐mediated C−O bond activation is observed at room temperature. The synthetic value of these densely functionalized silicon‐containing building blocks is demonstrated in a series of chemoselective transformations, including a [3,3]‐sigmatropic rearrangement for the construction of an α‐chiral silane.
The Dialuminene AriPr8AlAlAriPr8 (AriPr8=C6H‐2,6‐(C6H2‐2,4,6‐iPr3)2‐3,5‐iPr2)
Authors: Lehmann Annika , Queen Joshua D. , Roberts Christopher J. , Rissanen Kari , Tuononen Heikki M. , Power Philip P. 
Published: August 2024

AbstractCareful analysis of the crystals formed in the reduction of AriPr8AlI2 (AriPr8=C6H‐2,6‐(C6H2‐2,4,6‐iPr3)2‐3,5‐iPr2) with sodium on sodium chloride showed them to contain the long sought‐after dialuminene AriPr8AlAlAriPr8 (1) that forms alongside the previously characterized alanediyl :AlAriPr8. The single crystal X‐ray structure of 1 revealed a nearly planar, trans‐bent C(ipso)AlAlC(ipso) core with an Al−Al distance of 2.648(2) Å. The molecular and electronic structure of 1 are consistent with an Al−Al double dative interaction augmented with diradical character and stabilized by dispersion interactions. Density functional theory calculations showed that the reactivity of :AlAriPr8 with dihydrogen involves 1, not :AlAriPr8, as the reactive species. In contrast, the reaction of :AlAriPr8 with ethylene gave two products, the 1,4‐dialuminacyclohexane AriPr8Al(C2H4)2AlAriPr8 (2) and the aluminacyclopentane AriPr8Al(C4H8) (3), that can both form from the aluminacyclopropane intermediate AriPr8Al(C2H4). Although the [2+2+2] cycloaddition of 1 with two equivalents of ethylene was also calculated to be exergonic, it is likely to be kinetically blocked by the numerous isopropyl substituents surrounding the Al−Al bond. Attempts to fine‐tune the steric bulk of the terphenyl ligand to allow stronger Al−Al bonding were unsuccessful, leading to the isolation of the sodium salt of a cyclotrialuminene, Na2[AlAriPr6]3 (4), instead of AriPr6AlAlAriPr6.
Ultrasonic‐Driven Coordination Polymer Based on the Building Block [CuI (CN)4]3− and Heptane‐1,7‐diamine as a Luminescence Sensor and Efficient Catalyst for Pharmaceutical Wastewater Treatment
Authors: Saleh Dalia I. , Alhashmialameer Dalal , Mahmoud Samy F. , Etaiw Safaa Eldin H. 
Published: August 2024

ABSTRACTThe coordination polymer {[Cu6(CN)6]·HPD}n, CP1; (HPD = heptane‐1,7‐diamine) was prepared and characterized by single‐crystal and powder X‐ray diffraction, UV–Vis spectroscopy, electron microscopy (TEM and SEM), and elemental analyses. The copper atoms are coordinated by C ≡ N ligands, and both exhibit tetrahedral geometry. Cu1 and Cu2 create the pretty unique cluster structure of two quadruple [Cu2(μ3‐CN)2] units exhibiting coprophilic interaction. The building blocks [Cu3(CN)3]2 form fused distorted rectangular rings surrounded with the [Cu2(μ3‐CN)2] motifs exhibiting wide voids to accommodate the guest HPD. The structure of 1 indicates the formation of channels with dimensions 5.121–8.469 Ǻ which extend three‐dimensionally creating fused cavity morphology with different shapes. CP1 was utilized as an efficient sensor for selective quantitative estimation of metal ions (Co2+) and explosives (NB). Advanced oxidation process (AOP) was used as an efficient photocatalyst for the removal of the antibiotic meloxicam (MEL) utilizing AOP in the presence of H2O2 as an oxidant. Scavenge experiments, reusability of catalyst 1, and mechanism of oxidation were also discussed.
Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto‐Sensitive Tissue Engineering Strategies
Authors: Demir Didem , Ulusal Fatma , Ulusal Hasan , Ceylan Seda , Dağlı Sibel , Özdemir Nalan , Tarakçıoğlu Mehmet 
Published: August 2024

ABSTRACTThis work reports the assembly of mesoporous iron oxide nanoparticles (meso‐MNPs) with cryogel scaffolds composed of chitosan and gelatin. Meso‐MNPs with a particle size ranging from 2 and 50 nm, a surface area of 140.52 m2 g−1, and a pore volume of 0.27 cm3 g−1 were synthesized on a porous SiO2 template in the presence of PEG 6000 followed by leaching of SiO2. Different ratios of meso‐MNPs were successfully incorporated into chitosan:gelatin cryogels up to an amount equivalent to the entire amount of polymer. The morphological structure and physicochemical properties of the cryogels were directly affected by the amount of MNPs. VSM curves showed that all composite cryogels could be magnetized by applying a magnetic field. In the context of the safety of magnetic cryogel scaffolds for use in biomedicine, it is important to note that all values are below the exposure limit for static magnetic fields, and according to cytotoxicity data, scaffolds containing meso‐MNPs showed nontoxicity with cell viability ranging from 150% to 275%. In addition, microbial analysis with gram‐negative and gram‐positive bacteria showed that the scaffolds exhibited activity against these bacteria.
Economic freedom and corporate carbon emissions: International evidence
Authors: Ren Xiaohang , Li Wenqi , Cheng Xu , Zheng Xinwei 
Published: August 2024

AbstractA global consensus exists emphasizing the need to curtail carbon emissions to preserve the environment and promote sustainable development. In this study, we investigate the impact of economic freedom on corporate carbon emissions. We show that economic freedom negatively impacts corporate carbon emissions based on a panel dataset of 2,932 companies from 24 countries between 2004 and 2019. We also identify the underlying mechanisms involving resource utilization and industrial agglomeration. Additionally, we provide compelling evidence that carbon emissions reduction also boosts future economic performance. We also find that the effect of economic freedom on corporate carbon emissions is evident in companies facing elevated financial distress risks, high tax burdens, low financing constraints, and where the CEO serves on the board of directors. Moreover, we find that the escalation in economic freedom exhibits a notably stronger restraining effect on corporate carbon emissions in developed countries relative to developing nations. Overall, our findings contribute to a robust theoretical framework and provide valuable policy insights for the global effort to reduce carbon emissions.
Comprehensive analysis of diagnosis and treatment in 99 cases of abdominal Schwannoma
Authors: Fan Shaoqing , Wang Haiqian , Sun Xuemei , Gai Chunyue , Liang Ce , Wang Guiying , Niu Wenbo 
Published: August 2024

AbstractPurposeSchwannoma is a rare mesenchymal tumor. In this study, we analyzed clinicopathologically 99 schwannomas.This retrospective study delves into the clinical, pathological, and immunohistochemical dimensions of abdominal schwannomas.ResultsA cohort of 99 cases, comprising 4 malignant and 95 benign schwannomas, was meticulously examined. Clinical analysis revealed a notable gender distribution (1:1.7, male to female) and an average age of 58.5 years. The majority of cases were asymptomatic. A cohort of 99 cases, comprising 4 malignant and 95 benign schwannomas, was meticulously examined. Clinical analysis revealed a notable gender distribution (1:1.7, male to female) and an average age of 58.5 years. The majority of cases were asymptomatic. Tumor sizes ranged from 0.5 to 30 cm, with distinct locations in the stomach for most benign cases and the abdomen/small intestine for malignancies. Initial misdiagnoses were frequent. Pathological evaluations revealed distinct features, including Antoni A and B patterns, spindle cells, and lymphatic sheath structures in benign schwannomas. Malignant cases exhibited atypical cells, ulcers, and invasive growth. Immunohistochemical markers, such as S100, SOX10, and vimentin, consistently demonstrated positivity by contributing to accurate diagnoses. Treatment outcomes indicated a poor prognosis in malignant cases, with overall survival ranging from 10 to 41 months. Conversely, benign cases displayed no recurrence or metastasis during follow‐up, despite atypical behaviors.ConclusionThis study underscores the rarity of abdominal schwannomas and underscores the need for a comprehensive diagnostic morphology and immunohistochemistry. SOX10 emerges as a crucial and specific marker for accurate diagnosis. Further research is imperative to refine diagnostic protocols and enhance our understanding of the clinical behavior of abdominal schwannomas.
Introducing yoga‐integrated psychotherapy (YiP): A discussion paper
Authors: Childs‐Fegredo Jasmine 
Published: August 2024

AbstractDespite a plethora of treatments available for alleviating mental health issues, it has been reported that interventions, as they stand, are simply just not good enough (Kalin, Am. J. Psychiatry, 176, 2019, 885). Increasing figures of suicides are published each year, most recently standing at over 49,000 in the United States. Contested arguments continue in the field of psychotherapy with regard to finding the ‘best’ treatments for mental health issues. Recently, there have been calls for mental health practitioners and researchers to move towards innovation by asking different questions and creating new methods, albeit underpinned by rigorous scientific investigation. One such method currently being adopted with promising outcomes is the integration of mind–body techniques, such as yoga, into mental health treatments. Yoga is an ancient practice which provides a holistic system of healing and complementary philosophy to western understandings of the human mind. Like psychotherapy, yoga seems to work with unconscious processes, which can enable long‐term change. Combined with psychotherapeutic discovery, novel treatment models which incorporate both yoga and psychotherapy could therefore be provided. Yoga‐integrated psychotherapy (YiP), as a new model of treatment, could enhance outcomes for clients presenting with a range of difficulties as it aims to work with these methods as well as transdiagnostic understandings of distress. Additionally, YiP underscores the importance of a humanistic approach, which values the uniqueness of individuals and their subjective understandings of distress. Promising data from a recent pilot study of a YiP model in which participants describe the approach as ‘life changing’ form the basis of this discussion paper. The question arising is whether a humanistic and yoga‐integrated approach to psychotherapy could assist in enhancing client outcomes.