bluuebunny/crossref_metadata_2025_split huggingface dataset:
089 An international comparison of occupational guidelines for the management of mental disorders
Authors: Joosen M , Brouwers E , Beurden K van , Terluin B , Klink J van der , Verbeek J , Eguchi H , Woo J , Weeghel J van 
Published: August 2013

BackgroundTo address the problem of sickness absence due to mental disorders, guidelines have been developed in various countries.ObjectivesTo assess available guidelines on the management of mental disorders in an occupational health care setting on their quality and to compare recommendations.MethodsGuidelines were selected by systematically searching PubMed, Guidelines International Network Library, and National Guideline Clearinghouse. In addition, members of the International Commission on Occupational Health were consulted. Quality of guidelines was assessed with the AGREEII instrument and recommendations were compared.ResultsFifteen guidelines were included: 1 Japanese, 1 Danish, 2 Finnish, 2 South-Korean, 2 British and 7 Dutch. The quality of the guidelines varied. Barriers and facilitators for implementation (Applicability), competing interests (Editorial independences), and the process to gather and synthesise evidence (Rigour of Development) were poorest described. The domain Scope and Purpose scored highest. Recommendations concerning assessment refer to diagnostic classification, inventory of performance problems, causal factors and barriers for recovery. Specific workplace factors are often mentioned. Guidelines agree on work adaptation if necessary, psychological treatment and communication about treatment plan between involved actors.DiscussionGuidelines are difficult to find since they are commonly exclusively available in local languages. Therefore probably more guidelines exist then found. To learn from each other, guidelines should be translated into world languages and be accessible via international databases.ImplicationsGuideline developers can use AGREEII to increase quality. Although social context may differ among countries and can influence guideline recommendations, developers can learn from each other through reviews of this kind.
091 If we Build It, Will you Search for It? Finding Multiple Chronic Condition Guidelines in the National Guideline Clearinghouse
Authors: Haskell L , Jue J. , Cunningham S. , Nix M. , Coates V. 
Published: August 2013

BackgroundIn the US, it is estimated more than 25% of Americans have multiple chronic conditions (MCCs) and their care accounts for approximately 66% of total health care spending. Few clinical practice guidelines address MCCs.ObjectivesDetermine the number and scope of guidelines represented in the National Guideline Clearinghouse (NGC), funded by the Agency for Healthcare Research and Quality, addressing MCCs and provide strategies to identify these guidelines and facilitate quick retrieval by NGC users.MethodsWe searched for guidelines within NGC to identify those that address MCCs. We characterised these guidelines defining the number and type of MCCs addressed, the number of recommendations addressing MCCs, whether they addressed treatment, diagnosis, prevention or counselling, whether they graded the level of evidence, and whether the MCCs were concordant/discordant with the guideline’s primary disease/condition.ResultsFinal analysis of information collected and recommendations and strategies for facilitating retrieval of this content in NGC will be completed by June 2013.DiscussionTraditionally, guidelines focus on individual diseases so their application to the growing MCC population is limited. At the same time, evidence supporting recommendations for MCCs is lacking. Although our preliminary findings indicate that there are some guidelines addressing MCCs, there has been no obvious way to locate them on NGC.Implications for Guideline Developers/UsersGuideline developers need to create guidelines addressing MCCs. NGC aims to create ways to highlight MCC guidelines and make them easier to find and use.
092 From Manuscript to Mouse-Click: Moving From Print to Electronic Guidelines
Authors: Claase L , Phillips S , Hughes S , Norquay C 
Published: August 2013

BackgroundThe rapid uptake of electronic devices and information sources has enormous implications for guideline developers and implementers. In 2000, our organisation anticipated this trend and developed an electronic production system.ObjectivesTo develop the capacity to publish and update electronic versions of a comprehensive set of clinical guidelines.MethodsAn audit of technology and resourcing requirements was undertaken, new software was commissioned, and staff with IT and electronic publishing skills were recruited. Stringent quality control and editorial processes were developed to ensure the fidelity of electronic versions. A comprehensive communications and marketing plan was implemented.ResultsAll guidelines, covering 14 books titles and around 3000 topics, were integrated into an electronic, searchable website with links to other quality electronic resources, tools and reference materials.- Electronic subscriptions and site licenses have grown by 200% between 2004 and2012, and currently make up 75% of users; 25% continue to use books.DiscussionThe switch from paper to computer and mobile devices presents both financial and logistical challenges and requires long-term commitment. Furthermore, as the diversity of electronic integration systems multiplies, there are challenges in keeping up with technological advances. It is clear from the uptake of our electronic guidelines that health professionals and other users want access to comprehensive, up-to-date and easy-to-use electronic guidelines.Implications for Guideline Developers/UsersFor guidelines to be useful in practice in 2013 and beyond, they must be available electronically and be able to interact with other electronic resources used in health settings.
P005 Integration of evidence on patient preferences in health care decision-making: current state of play
Authors: Utens C , Weijden T van der , Joore M , Dirksen C 
Published: August 2013

BackgroundActive patient participation is embedded in health care decision-making, like clinical practice guideline (CPG) development and coverage decisions. The systematic use of the available evidence on patient preferences (passive participation) is still limited.ObjectivesTo describe how and what type of evidence on patient preferences is considered in health care policy decisions in The Netherlands, England, Scotland, Germany and France.MethodsA document search on website and database of responsible organisations for material on current development procedures. Scoping literature search on opinion papers on the use of research on patient preferences in CPG development and coverage decisions (HTA). Selected CPG and coverage decisions were checked.ResultsProcedures for coverage decisions do not mention the search for or use of research on patient preferences, nor was information found in the coverage case studies. In CPG development procedure a mandatory (Scotland) or optional (Netherlands) search for studies that reflect patients’ experiences and preferences is described. The CPG case studies show various use of patient preferences in different conceptualisations.DiscussionIn coverage decisions research on patient preferences has no formal role yet. In CPG this role is limited. Integration of research on patient preferences is hampered by several factors.Implications for Guideline Developers/UsersDirections for the future include: 1) conceptual work on defining and measuring patient preferences; 2) reaching consensus on the value and place of research on patient preferences for and in procedures and 3) developing a strategy for integration in procedures.
P012 Systematic review of HPV test [Invader Technology/Real-Time PCR]
Authors: Shin H , Lee S , Lee K , Choi W , Kim T , Moon H , Kim H , Lee K , Kim E 
Published: August 2013

ObjectiveHPV Test [Invader Technology/Real-Time PCR] is a molecular genetic test performed for confirming the presence of infection by detecting 14 types of HPV and additionally, for classifying types 16 and 18 genotypes.MethodsIt was assessed using 8 domestic databases including Korea Med and Ovid-MEDLINE, Ovid-EMBASE. 1,214 works were identified. Of them, animal experimental or studies not published in Korean or English were excluded. Total of 23 literatures composed of 8 literatures for Invader Technology and 15 literatures on Real-Time PCR were included in the final assessment. Two reviewers screened all references independently, for assessing included articles quality and extracted data.ResultsIndex tests were assessed to be a safe test, since it does not impart direct harm to the patients as it is conducted outside the patients body by collecting uterus cervical cells. Effectiveness was assessed by diagnostic accuracy, concordance rate, detection rate. Diagnostic accuracy of Invader Technology with sequencing was high (sensitivity=0.89, specificity=0.92). As the result of comparison between Invader Technology and Hybrid Capture 2(HC2), the false positive rate of index test (5.8%) was lower than HC2 (5.5–21.9%). The concordance rate was 83.1%-94.0%. Diagnostic accuracy of Real-Time PCR with DNA chip was high level (sensitivity=0.96, specificity=1.00). Rate of concordance between Real-Time PCR and HC2 was in the range of 82.6–98.3%, with DNA chip was in the range of 66.7–98.3%.ConclusionThese tests are safety. Also, there are the effectiveness of additional diagnosis for genotypes 16 and 18, high level of concordance with the existing tests and high level of detection of HPV genotypes 16 and 18 in high risk group.
P016 A guideline on undescended testis: more transparency by a decision analysis
Authors: Kamphuis M , Marle E van den Akker-van , Gameren-Oosterom H van , Pierik F 
Published: August 2013

BackgroundUndescended testis (UDT) is the most common genital anomaly seen in boys and can be treated surgically by orchiopexy. The age at which orchiopexy should be performed is controversial for both congenital and acquired UDT.ObjectivesPerforming a decision analysis in order to develop a guideline on UDT.MethodsA decision analysis was performed in which all available knowledge is combined to assess the outcomes of orchiopexy at different ages, expressed in quality adjusted life years (QALY). Furthermore a sensitivity analysis was performed to assess whether the determined optimal age of orchiopexy is influenced by gaps in current knowledge.ResultsSurgery at the earliest age (at detection of UDT) will lead to the lowest loss in QALY for UDT compared to no surgery. For bilateral UDT (both congenital and acquired) this was caused by increased paternity and for unilateral UDT by cosmetic aspects. Sensitivity analyses did not change the preferences for strategies. However, given the modest differences in outcomes, there is room for patient preference with respect to performance and timing of surgery in case of unilateral UDT.DiscussionThe choice for no surgery in case of unilateral UDT was not acceptable for the expert group. Therefore, a consensus based guideline was developed in which surgery was recommended also for unilateral UDT. More clinical evidence on issues related to timing may in the future modify these results and hence this advice.Implications for Guideline Developers/UsersA decision analyses provides a clear insight in the data available and argumentations made.
P023 Observational Drug Therapy Trials Add Up Useful Information As Compared With Randomised Controlled Trials: Case Multiple Sclerosis
Authors: Atula S , Lodenius L , Komulainen J 
Published: August 2013

BackgroundClinical practice guidelines (CPG’s) are predominantly based on randomised controlled trials (RCT’s). However, the number of published observational, non-randomised trials is high and yet, the information they contain is often excluded while compiling CPG’s.ObjectivesWe compared randomised and observational clinical treatment trials, published within one year, using multiple sclerosis (MS) as a model. The aim was to find out whether valuable information for CPG’s can be discovered by using observational studies.MethodsWe collected all publications of MS treatment in Medline during year 2012, using Scottish Intercollegiate Guidelines Network (SIGN) search filtres for randomised and observational trials for making a systematic literature review. The clinical drug trials on adults with MS, published in English were included. Case reports and symptomatic treatment trials were excluded.ResultsA total of 24 RCT’s and 45 observational trials were found. The median number of participants in RCT’s was 430 (range 66 to 2244) and in observational trials 118 (range 5 to 22255). Twenty RCT’s were efficacy trials, 2 evaluated health economics and one each safety and pharmacology. Twenty-eight observational trials had efficacy as a primary end-point, 10 addressed safety, 5 treatment adherence and one each pharmacology and health economics.DiscussionMost trials addressing safety or compliance issues were observational, therefore important safety and adherence data could be lost by omitting them.Implications for Guideline Developers/UsersObservational trials should be considered while compiling CPG’s.
P030 E-Tool For Patients with Non-Hodgkin’s Lymphoma to Improve Guideline Adherence
Authors: Stienen J , Hermens R , Krieken H van , Schans S van de , Dekker H , Maazen R van der , Wennekes L , Blijlevens N , Ottevanger N 
Published: August 2013

BackgroundPatient education should be part of improvement strategies to increase guideline adherence by professionals.ObjectivesThis study evaluates an e-tool designed in response to patients’ need for more complete information regarding diagnostics, therapy and after-care (based on previous research). The e-tool aims to inform patients about non-Hodgkin’s lymphoma (NHL)-care and gives patients the possibility to check their own care pathway and register personal experiences.MethodsThe e-tool was developed in consultation with the Dutch Lymphoma Patients Organization and evaluated by NHL-patients, professionals and laymen. Feedback was asked concerning lay-out, user convenience, information provision and general strengths and weaknesses of the e-tool. The effect of the e-tool is now tested in 9 Dutch hospitals. Patients are included from November 2012 to November 2013. All patients receive patient information and an informed consent form. The process of inclusion is continuously monitored.ResultsIn the development phase, 18 out of 26 feedback forms were filled out. Information needs were satisfactory and clearness of navigation and information on new therapies were improved after feedback. In the first 3 months of the testing phase, 25 of the historically estimated 50 patients received patient information, 12 consented and 8 used the e-tool.DiscussionThe e-tool seems feasible to empower patients regarding their NHL-care pathway. However, distribution of patient information is not yet optimal. Patients’ experiences with the e-tool and possible effects on quality of care is tested in a randomised controlled trial.ImplicationsEducational e-tools for patients may help to improve guideline development and adherence.
P041 Sustaining organizational capacities of knowledge utilization: A complete toolbox for the health and social services organizations
Authors: Chagnon F , Bardon C , Houlfort N , Proulx R , Labelle P , Gervais M 
Published: August 2013

BackgroundDespite research and funding, the understanding of organization’s capacities of knowledge utilisation remains incomplete in health and social field.ObjectivesTo better understand organisational determinants of research result utilisation.MethodBetween 2009 and 2012, managers (n = 75) from health and social services organisations (N = 8) have actively contributed in a participative research action process. Additionally professionals and managers (N = 2161) have answered questionnaires. Qualitative and quantitative data gathered on the organisational outcomes as well as on the process of using our tool provided empirical validation. This iterative process led to the creation of a complete toolbox designed to help organisations raise to the knowledge transfer and utilisation challenge.ResultsThe toolbox includes a conceptual framework, a user’s guide and two questionnaires to establish a diagnostic of the organisation’s capacities of knowledge utilisation and to identify the main strategies to improve them. At the root of our toolbox is a theoretical model of organisational capacities to use knowledge, specific to health and social services organisations, that we have developed. Our model includes eight components: organisational culture, vision and leadership, knowledge acquisition, reflexivity, integration, creation and dissemination, adaptation, and relationships.DiscussionThe results demonstrate that the toolbox helps decision makers to develop a common understanding of their organisation’s strengths and weaknesses in terms of research knowledge utilisation capacities. Implications:The research and toolbox developed by our team provide a first step in unveiling the intricacies of knowledge utilisation in the social services sector. Eight key organisational capacities were found to be essential in facilitating and promoting knowledge utilisation in health and social services.
P042 Evidence-based guideline on pharmacological management of osteoarthritis of knee in primary care settings in Hong Kong
Authors: Ng M , Lam W , Hui Y 
Published: August 2013

BackgroundOsteoarthritis (OA) is a common degenerative joint condition. Family physician plays an important role in the management.ObjectivesThe guideline seeks to assist primary health care professionals to help patients with OA knee to improve quality of life using pharmacological measures to relieve symptoms, improve drug use and reduce adverse drug incidents.MethodsThe guideline is based on evidence-based literature review and was synthesised in accordance with SIGN methodology. A systematic review of literature was carried out using an explicit search strategy devised by a SIGN Information Officer. Each of the selected papers was evaluated using standard SIGH methodological checklists and the articles were subsequently reviewed. The guideline was synthesised by adaptation recommendations using the AGREE Tool. The recommendations were then modified based on the latest best available evidence. The guideline was finally reviewed internally and externally.ResultsThe first line drug treatment of OA knee is paracetamol in regular divided doses to a maximum of 4g/day. There is good evidence to prescribe NSAID or COX-2 NSAID for reducing pain in short term. Family physician may consider prescribing weak or strong opioids with caution for moderate or severe pain. Intra-articular corticosteroid injections for short term relief can be considered. Family physician may also consider use of topical NSAIDs and hyaluronic acid.ConclusionsUse of appropriate pharmacological measures can effectively relieve symptoms, improve functions and reduce adverse drug incidents.
P044 Quality assessment of traditional Chinese clinical guidelines: 2003–2012
Authors: Chen Y , Yao L , Wang Q , Wei D , Wang X , Yang K 
Published: August 2013

BackgroundLittle is known about quality and quantity of traditional Chinese clinical guidelines. We aim to systematically review all of traditional Chinese clinical guidelines.MethodsWe searched CNKI (China National Knowledge Infrastructure/Chinese Academic Journals full text Database), VIP (a fulltext database of China), WANFANG (a fulltext database of China) and CBM (China Biomedicine Database Disc). Two groups of review authors independently applied inclusion criteria, assessed trial quality, and extracted data.ResultsWe identified 75 traditional Chinese clinical guidelines from 2003 to 2012, and only 11(15%) were claimed that an evidence based approached were used in the process of development. From the assessment with the Appraisal of Guidelines for Research and Evaluation II (AGREE II), the mean scores were low for the domains ‘clarity of presentation’ (28%), ‘scope and purpose’ (15%) and ‘editorial independence’ 12%; and very low for the other domains (‘stakeholder involvement’ 8%, ‘rigour of development’ 5% and ‘applicability’ 3%). AGREE II mean scores of traditional Chinese clinical guidelines lower than Chinese clinical practice guidelines and the world average.ConclusionsTraditional Chinese clinical guidelines received lower scores, which indicate a relatively poor quality of the guidelines. However, there was some increase over time. Meanwhile, given the characteristics of Traditional Chinese medicine, CONSORT group has been developing CONSORT for TCM and for Acupuncture, we plan to develop AGREE TCM to be used to inform the development, appraisal and reporting of evidence-informed traditional Chinese clinical guidelines.
P050 ‘Food and Eating behaviour’ – Development of a Guideline for Dutch Preventive Child Health Care
Authors: Lanting C , Heerdink-Obenhuijsen N , Kamphuis M 
Published: August 2013

BackgroundMany parents worry that their child is eating either too much or too little. In The Netherlands, Preventive Child Health Care (PCHC) is the main source of advice and information on food and eating behaviour. Yet, evidence on the subject is sparse and scattered. The Dutch Ministry of Health Welfare and Sports, therefore, requested a guideline; the PCHC-guideline should fit together with a guideline for paediatricians on the same subject, which was developed concurrently.ObjectivesTo develop a national guideline for PCHC-professionals on the subject to enhance uniform, evidence-based practice.MethodsA working group of guideline developers, epidemiologists, and dieticians, together with professionals in PCHC, child-psychology and -pedagogics, and a pre-speech therapist developed the guideline, according to the principles of evidence-based medicine. Close collaboration took place with a group of paediatricians developing the new guideline ‘Signalling somatic causes of abnormal nutritional behaviour in children’. Questions were formulated by the working group and evidence was extracted from literature, supplemented by practice-based consensus. The guideline was piloted in several PCHC settings.ResultsTogether with a group of child psychologists and psychiatrists, referral criteria for eating disorders were agreed on. Paediatricians formulated ‘Somatic alarm symptoms’. Discussion Working with a large, interdisciplinary group of guideline developers carries the risk of collaboration problems, but when managed successfully, adds value to the end product.Implications for Guideline Developers/UsersIn order to avoid collaboration problems, the scope of the guideline was agreed on in an early stage. Interdisciplinary collaboration enhanced guideline quality.