bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemotherapy With Erlotinib or Chemotherapy Alone in Advanced Non-Small Cell Lung Cancer With Acquired Resistance to EGFR Tyrosine Kinase Inhibitors
Authors: Goldberg Sarah B. , Oxnard Geoffrey R. , Digumarthy Subba , Muzikansky Alona , Jackman David M. , Lennes Inga T. , Sequist Lecia V. 
Published: September 2013

Abstract

Purpose.
Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer has an oncogene-addicted biology that confers sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Published data suggest that EGFR addiction persists after development of TKI acquired resistance, leading many clinicians to continue TKI with subsequent chemotherapy; however, this strategy has not been formally evaluated.

Methods.
We retrospectively reviewed an institutional database to identify patients with advanced EGFR mutation with acquired resistance who subsequently received chemotherapy. Patients were classified as receiving chemotherapy with continued erlotinib or chemotherapy alone. We assessed differences in outcomes between the two strategies.

Results.
Seventy-eight patients were included, 34 treated with chemotherapy and erlotinib and 44 treated with chemotherapy alone. Objective response rate was evaluable in 57 patients and was 41% for those treated with chemotherapy and erlotinib and 18% for those treated with chemotherapy alone. After adjusting for chemotherapy regimen and length of initial TKI course, the odds ratio for the response rate was 0.20 (95% confidence interval: 0.05–0.78; p = .02) favoring treatment with chemotherapy and erlotinib. The median progression-free survival was 4.4 months on chemotherapy and erlotinib and 4.2 months on chemotherapy alone (adjusted hazard ratio = 0.79; 95% confidence interval: 0.48–1.29; p = .34). There was no difference in overall survival.

Conclusion.
This is the first study, to our knowledge, to demonstrate that continuation of EGFR TKI with chemotherapy in patients with acquired resistance improves outcomes compared with chemotherapy alone. We observed an improved response rate but no difference in progression-free survival or overall survival. A larger prospective clinical trial is needed to evaluate this promising strategy further.
Semi-analytical model of Raman generation in silicon-on-insulator rib waveguide with DBR/F-P resonator
Authors: Tyszka-Zawadzka A. , Szczepański P. , Mossakowska-Wyszyńska A. , Karpierz M. , Bugaj M. 
Published: September 2013

AbstractAn approximate method of modelling of Raman generation in silicon-on-insulator (SOI) rib waveguide with DBR/F-P resonator including spatial field distribution and nonlinear effects such as Raman amplification and two photon absorption (TPA), is developed. In threshold analysis of steady-state Raman laser operation, an analytical formula relating threshold pump power to the system parameters is obtained. The analysis of the above threshold operation is based on an energy theorem. In exact energy conservation relation, we approximate the Stokes field distributions by that existing at the threshold, whereas the approximate pump field distributions are obtained by integrating the equations for the pump signal using the linear (threshold) pump field distributions and the threshold Stokes field distributions. An approximate, semi-analytical expression related the Raman output power to the pump power and system parameters is derived. Our calculations remain in a good agreement with the exact numerical solutions.
Scientific realism and philosophical naturalism in Šmajs’ evolutionary ontology
Authors: Melichová Inéz , Burgan Robert 
Published: September 2013

Abstract
J. Šmajs’ concept of evolutionary ontology has attracted much attention in recent years especially in Czech and Slovak academic circles, yet it remains, as some of its proponents claim, undervalued in Britain and the US. Even in the Czech Republic and Slovakia, there are, in addition to its strong supporters, several authors who almost a priori reject the concept, pointing to several questionable, contradictory or even mutually exclusive or self-refuting arguments. In this paper, mainly based on a comprehensive analysis of the first part of Šmajs’ book, Evoluční ontologie kultury a problém podnikání (2012) [Evolutionary Ontology of Culture and The Issues Of Business], we attempt to demonstrate that the opponents of Šmajs’ concept are closer to the truth, since the concept, we believe, is just another variation on the extreme escalation of philosophical naturalism.
Nesting by Hobbies (Falco subbuteo) in the Košice Basin (Eastern Slovakia) from 1996 to 2005
Authors: Lipták Ján 
Published: September 2013

Abstract
In the course of ten nesting seasons from 1996 to 2005 I observed nesting by hobbies in Eastern Slovakia within a territory of 1000 km2 in the Košice Basin. During this ten-year period 218 nestings were recorded. The average population density was two pairs per 100 km2 in the monitored territory. In certain quadrants with better occupation it was from four to seven pairs per 100 km2. The birds nested more frequently on very high tension (VHT) electricity pylons (126 instances) than in trees (92 instances). They prefer the nests of hooded crows (Corvuscorone cornix) (110 cases) and ravens (Corvus corax) (90 cases), and in only 18 cases did they use another nesting solution. When nesting in VHT pylons in the 1980’s they used to make more use of crows’ nests, but at the present time they prefer ravens’ nests to a significant degree.
Patient Empowerment by Increasing the Understanding of Medical Language for Lay Users
Authors: Stoicu-Tivadar V. , Topac V. 
Published: September 2013

SummaryBackground: Patient empowerment is important in order to increase the quality of medical care and the life quality of the patients. An important obstacle for empowering patients is the language barrier the lay patient encounter when accessing medical information.Objectives: To design and develop a service that will help increase the understanding of medical language for lay persons.Methods: The service identifies and explains medical terminology from a given text by annotating the terms in the original text with the definition. It is based on an original terminology interpretation engine that uses a fuzzy matching dictionary. The service was implemented in two projects: a) into the server of a tele-care system (TELEASIS) with the purpose of adapting medical text assigned by medical personnel for the assisted patients. b) Into a dedicated web site that can adapt the medical language from raw text or from existing web pages.Result: The output of the service was evaluated by a group of persons, and the results indicate that such a system can increase the understanding of medical texts. Several design decisions were driven from the evaluation, and are being considered for future development. Other tests measuring accuracy and time performance for the fuzzy terminology recognition have been performed. Test results revealed good performance for accuracy and excellent results regarding time performance.Conclusion: The current version of the service increases the accessibility of medical language by explaining terminology with a good accuracy, while allowing the user to easily identify errors, in order to reduce the risk of incorrect terminology recognition.
Can cytomorphology of granulomas distinguish sarcoidosis from tuberculosis? Retrospective study of endobronchial ultrasound guided transbronchial needle aspirate of 49 granulomatous lymph nodes
Authors: Kaur Gagandeep , Dhamija Amit , Augustine Jolsana , Bakshi Pooja , Verma Kusum 
Published: September 2013

Background:
The differential diagnosis of tuberculosis (TB) and sarcoidosis on fine needle aspiration material is very challenging in tubercular endemic regions. We carried out a pilot study to explore cytomorphologic features of granulomas which could help in differentiation between sarcoidosis and TB. Final diagnoses in these patients were based on clinical, microbiologic and follow-up studies.

Materials and Methods:
Endobronchial ultrasound guided transbronchial needle aspiration smears of 49 consecutive patients with a final cytologic diagnosis of granulomatous lymphadenitis were reviewed. Based on cytologic features two cytologic categories were enunciated and the results were correlated with microbiologic studies and/follow-up of minimum of 6 months.

Results:
The cytologic categories did not correlate with the final clinical outcome of patients.

Conclusions:
Different patterns of granulomas observed in cytology smears do not help distinguish TB from sarcoidosis. The novel non-invasive techniques of mediastinal sampling though help in confirming granulomatous pathology, distinction between these entities and treatment decisions still depend upon correlating cytologic, microbiologic, clinical and radiological data in a large number of cases in tubercular endemic regions.
Prevalence and Degree of Breast Arterial Calcifications on Mammography: A Cross-sectional Analysis
Authors: Loberant Norman , Salamon Vera , Carmi Nurit , Chernihovsky Anna 
Published: September 2013

Objectives:
The purpose of this study is to establish a database including prevalence and degree of breast arterial calcifications (BAC) in our population of women presenting for mammography.

Materials and Methods:
The mammograms of 1786 women over the age of 40 years were examined for the presence and degree of BAC. Statistical analysis was performed to correlate patient's age and ethnic origin with the presence and degree of BAC.

Results:
There was statistically significant and strong correlation between the patient's age and presence of BAC. There was also a less strong yet statistically significant correlation between patient age and degree of BAC. Regression analysis showed the likelihood of BAC at various ages. The prevalence of BAC is only 2% of women under 50 years of age; the prevalence of Grade 2-3 BAC is only 1% in women under 60 years of age.

Conclusion:
There is a predictable increase with age in both prevalence and degree of BAC in women. The presence of high degree BAC in women under 60 years of age or any BAC in women under 50 years of age is unusual.
Les impressions d’un futur Premier ministre belge au Canada
Authors: Warren Jean-Philippe , Van Den Dungen Pierre 
Published: September 2013

Hubert Pierlot (1883-1963) a été Premier ministre de Belgique entre 1939 et 1945. En 1910, le Congrès eucharistique international qui se tient à Montréal lui offre l’occasion de traverser l’Atlantique. Le jeune homme, déjà intéressé par laRes Publica, découvre lors de son voyage les Canadiens français dont il va aussitôt célébrer, la double identité : la patrie et la foi. Le Canada français représente alors pour lui un véritable modèle « moral », sinon un espoir car il a la possibilité de rejoindre la Belgique sur la voie de l’industrialisation sans renier son passé et ses traditions, conjuguant les innovations techniques et le respect dû aux choses de l’esprit, qu’elles soient religieuses ou aristocratiques. C’est pourtant lors d’un voyage de chasse au Lac-Saint-Jean qu’il pensera avoir touché au plus près de la vie authentique des habitants. Au moment de son entrée dans la carrière politique, en 1925, Pierlot n’aura pas oublié les leçons tirées de son périple transatlantique.
Accents in Business Communication: An integrative model and propositions for future research
Authors: Mai Robert , Hoffmann Stefan 
Published: September 2013

AbstractToday's business interactions are characterized by encounters between people with diverse language backgrounds. This article examines how, why and under what circumstances regional or foreign speech patterns affect consumer judgments and reactions. Building on a synthesis of accent research and theories, including the work of related disciplines such as linguistics and social psychology, this article suggests an integrative model that helps to understand accent effects in business contexts. The model disentangles the effects of social categorization, stereotype activation, and speech processing that jointly influence different business‐related outcomes. The model highlights three categories of factors that moderate these accent effects, namely sender, receiver, and communication variables. The paper further identifies several issues which remain unresolved and which require continued research. An agenda for future research sets out several propositions to help researchers approach regional and foreign accents in business environments.
The Progressive Unfolding of the Powers of the United States: Presidential Address, Eighth Annual Meeting of the American Political Science Association
Authors: Baldwin Simeon E. 
Published: September 2013

When the Constitution of the United States was pending for ratification, its supporters, in their public utterances, were disposed to minimize the powers which it conferred. This was the general tone of the Federalist. How far they might reach, indeed, was a question that only the future could fully answer. A set of traditions and usages and precedents must first grow up, under the Constitution, but outside of it.Every one saw that much would depend on the views of Washington. Every one looked forward with confidence to his unanimous election as the first President. Every one saw that it would be left to him to decide whether he should be reelected. His refusal to stand for a third term founded a usage that has become as controlling as an express constitutional provision.Washington took care that the judiciary should be composed of men who believed that Congress was not confined to the exercise of the powers expressly granted to it.
THE -COHOMOLOGY RINGS OF -MANIFOLDS
Authors: HILLMAN J. A. 
Published: September 2013

AbstractWe compute the rings ${H}^{\ast } (N; { \mathbb{F} }_{2} )$ for $N$ a closed $ \mathbb{S} {\mathrm{ol} }^{3} $-manifold, and then determine the Borsuk–Ulam indices $\text{BU} (N, \phi )$ with $\phi \not = 0$ in ${H}^{1} (N; { \mathbb{F} }_{2} )$.
Carotenoid-rich dietary patterns during midlife and subsequent cognitive function
Authors: Kesse-Guyot Emmanuelle , Andreeva Valentina A. , Ducros Véronique , Jeandel Claude , Julia Chantal , Hercberg Serge , Galan Pilar 
Published: September 2013

Carotenoids may help to prevent the ageing of the brain. Previous findings regarding β-carotene alone are not consistent. In the present study, we evaluated the cross-time association between a carotenoid-rich dietary pattern (CDP) and subsequent cognitive performance using a sample of 2983 middle-aged adults participating in the SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study. Cognitive performance was assessed in 2007–9 using six neuropsychological tests, and a composite cognitive score was computed. The cognitive data were related to dietary data obtained by repeated 24 h dietary records (1994–6) and to measurements of baseline plasma concentrations of carotenoids (lutein, zeaxanthin, β-cryptoxanthin, lycopene, α-carotene, trans-β-carotene and cis-β-carotene). DP were extracted using the reduced rank regression method for 381 participants and then extrapolated to the whole sample using plasma carotenoid concentrations as response variables. Associations between a CDP and cognitive function measured 13 years later were estimated with ANCOVA providing mean difference values and 95 % CI across the tertiles of CDP. A correlation between CDP and consumption of orange- and green-coloured fruits and vegetables, vegetable oils and soup was observed. CDP was found to be associated with a higher composite cognitive score (mean difference 1·04, 95 % CI 0·20, 1·87, P for trend 0·02), after adjustment for sociodemographic, lifestyle and health factors. Similar findings were obtained for scores obtained in the cued recall task, backward digit span task, trail making test and semantic fluency task (all P for trend < 0·05). Further studies ought to confirm whether a diet providing sufficient quantity and variety of coloured fruits and vegetables may contribute to the preservation of cognitive function during ageing.
EFFECT OF CONSERVATION AGRICULTURE ON MAIZE YIELD IN THE SEMI-ARID AREAS OF ZIMBABWE
Authors: NYAMANGARA J. , NYENGERAI K. , MASVAYA E. N. , TIRIVAVI R. , MASHINGAIDZE N. , MUPANGWA W. , DIMES J. , HOVE L. , TWOMLOW S. 
Published: September 2013

SUMMARYGlobally, a range of agronomic factors have been reported to have an impact on the performance of conservation agriculture (CA) and often determine its performance in relation to conventional agriculture (CONV). To assess this performance in Zimbabwe, 48 CA experiments were conducted by the International Crops Research Institute for the Semi-Arid Tropics in the semi-arid areas of southern Zimbabwe from 2004 to 2010, to calculate the weighted mean difference (WMD) through meta-analytical methods. The two CA practices, planting basins (Basins) and ripper tillage (Ripper), were compared with CONV. It was hypothesised that CA results improved yield compared with CONV and that the effect of CA practices on yield is affected by soil type, rainfall amount and distribution and selected management practices, which included rates of inorganic fertilisers and manures and mulching. Basins were superior to CONV in 59% of the experiments and the overall effect was significant (p< 0.001). The effect of Ripper was non-significant. The hypothesis that CA practices result in improved maize grain yield over CONV was accepted for Basins. The WMD for experiments conducted on sandy soils was 0.365 t ha−1for Basins and 0.184 t ha−1for Ripper, and in both cases was significant (p< 0.05). For clay soils, only the WMD for Basins was significant. A higher rainfall regime (500–830 mm) resulted in a lower WMD for Basins (0.095 t ha−1) and Ripper (0.105 t ha−1) compared with 0.151 t ha−1for Basins and 0.110 t ha−1for Ripper under lower rainfall (320–500 mm). The overall effect of Basins under the higher rainfall regime was not significant. There was better yield performance for Basins when the rainfall was well distributed; the reverse was noted for the Ripper. The application of 10–30 kg ha−1of N (micro-dose range) resulted in a higher WMD for Basins than zero N application. Without N application, the WMD of Basins was not significant. For zero manure application in Basins, the WMD was 0.043 t ha−1compared with 0.159 t ha−1when manure was applied. The application of mulch depressed the WMD in Basins by 44% and Ripper by 89%. The hypothesis that yield performance under CA is influenced by soil type, rainfall amount and distribution, inorganic fertiliser and manure application was accepted.
Late Burials from Mycenae
Authors: Desborough V. R. 
Published: September 2013

This cist tomb was uncovered in 1959 during the excavation of the House of Sphinxes,2 and it lay at a distance of only 2 m. from tomb PG 606 (see fig. I and BSA li. 114 fig. 5).It was built on the rock where there was a natural angle and a fairly sharp slope from west to east. The floor of the tomb was in fact for the most part the rock itself, but at the east end a number of small stones, overlying Mycenaean debris, were used. It was of rectangular shape, and orientated W.-E. The west and south walls of the tomb were provided by the rock; two large worked slabs, set upright, formed the north-east corner, and for the rest natural stones were used to line the tomb. There was no evidence of any roofing slabs, nor can one see how such could have been fixed. The inner dimensions were 1·78 × 0·68 m., and the two walling slabs had a height of 0·60 m.
A Note on the LM IB Marine Style at Knossos
Authors: Mountjoy P.-A. 
Published: September 2013

The published corpus of LM IB Marine Style pottery from Knossos is small. It includes:
1. A jar from the Royal Road, AR (1961–2) 28 fig. 36.2. A jar from the South-west Corner of the Palace, PM iv 280 fig. 215.3. A ewer from the House of the Sanctuary, ibid, iv 215 fig. 165.4. A tall alabastron from the Tomb of the Double Axes, TDoAx. 87.5. A bridge-spouted jar from a chamber tomb near the Temple Tomb, PM iv 279 fig. 214.6. A fragment from a jar, ibid, ii 506 fig. 310a.7. A fragment from a flower-pot, ibid, ii 506 fig. 310b–c.
The Seals and Sealings from the Citadel House Area: A Study in Mycenaean Glyptic and Iconography
Authors: Tamvaki Angela 
Published: September 2013

The excavations in the Citadel House area have produced an appreciable number of seals and sealings, of which the importance is increased by the late contexts (LH IIIB 1 or 2, LH IIIC), in which the majority of them were found.Of the eighteen objects discussed here, four are complete seals (nos.1–3, 5), one is an unfinished seal (no.4), five are broken beads probably used as seals (nos.6–10), and eight are sealings (nos.11–18), of very unequal state of preservation and importance. Four of the latter (nos.11, 14, 15, 17), are of really fine workmanship and of considerable iconographical interest. Not only are their subjects clearly recognizable, but they are also worth a closer study and discussion, because of their unusual arrangement and the presence of some unexpected details.
Athens Honours Proxenos (IG i2. 146)
Authors: Walbank Michael B. 
Published: September 2013

This document is one of a number of Attic proxeny-decrees that A. G. Woodhead considered to be evidence for Athenian concern with the south-west Aegean towards the end of the fifth century B.C. He identified the honorand Proxenos as a native of Chalke, a small island off the west coast of Rhodes. I share the view of J. and L. Robert that Woodhead has not proved his case either for the date or for the ethnic.The inscription is non-stoichedon, its engraving inexpert and careless, with several mistakes untidily erased and corrected. There is a mixture of Attic and Ionic letter-forms in the first three lines (gamma, eta, and lambda are Ionic, while xi is written chi sigma); otherwise the lettering is Attic, indicating a date before 403 B.C.
The Linear B Inscribed Stirrup Jars and West Crete
Authors: Catling H. W. , Cherry J. F. , Jones R. E. , Killen J. T. 
Published: September 2013

The four authors of this paper have worked in close consultation throughout the project, and present a joint result rather than so many separately initialled sections. Catling has most responsibility for the archaeological matter, Jones for the analytical work, Cherry and Jones for the interpretation of the results of the analyses and Killen for the epigraphic comment.It must be noted that a single series of numbers, 1–108, is used throughout this paper to distinguish the test samples. The significance of these numbers is made clear in the Catalogue and Concordances.
Two notes on possible Hestiatoria
Authors: Tomlinson R.A. 
Published: September 2013

1 A Note on an Inscription from Chorsiai: Hestiatoria in BoeotiaThe inscription is SEG XXIV 361. Originally published by N. Platon and M. Feyel in BCH LXII (1938) 149–66, the occasion for its appearance in SEG was the detailed study b J. Taillardat and P. Roesch, Rev. Phil. (IIIe Sér) XL 1966 70–87.