bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproductive health in women with serious mental illnesses
Authors: Özcan Neslihan Keser , Boyacıoğlu Nur E , Enginkaya Semra , Dinç Hüsniye , Bilgin Hülya 
Published: April 2014

Aims and objectivesTo determine what problems female psychiatric patients have in terms of reproductive health.BackgroundThe reproductive health problems faced by female psychiatric patients are matters that have been neglected in the areas of both psychiatry and women's health. This study aims to make a contribution from Turkey to the literature in this neglected field.DesignThe study is descriptive and was conducted with 292 female patients treated in an acute inpatient psychiatric ward.MethodsData were collected through face‐to‐face interviews and a questionnaire based on the literature and prepared by the researchers which was designed to determine the kinds of reproductive health issues the patients were experiencing.ResultsIt was found that compared with healthy women, the distinctive features of the participants in terms of sexuality were more negative; in particular, patients diagnosed with bipolar disorder were more likely to have been forced by their partners to have sex, they had suffered from rape or sexually transmitted diseases, the majority of those who had previous sexual experience had tried to use contraceptives but had been unable to continue using them, they were most likely to choose the method of withdrawal for contraception, their rates of pregnancy and abortion were high, they received less antenatal care, and they were more likely to have smoked during pregnancy.ConclusionsIt was found that female patients with psychiatric disorders had more negative attributes with regard to marriage, sexuality, family planning, maternal characteristics and pregnancy, compared with a corresponding healthy population.Relevance to clinical practiceThe results of this study may be useful for nurses in the clinical field for calling an attention and raising an awareness of the reproductive health problems of women with psychiatric disorders, taking the necessary preventive measures, and developing damage‐reducing strategies.
Personality Interacts With Implicit Affect to Predict Performance in Analytic Versus Holistic Processing
Authors: Kazén Miguel , Kuhl Julius , Quirin Markus 
Published: April 2014

AbstractBoth theoretical approaches and empirical evidence suggest that negative affect fosters analytic processing, whereas positive affect fosters holistic processing, but these effects are inconsistent. We aim to show that (a) differences in affect regulation abilities (“action orientation”) and (b) implicit more so than self‐reported affect assessment need to be considered to advance our understanding of these processes.Forty participants were asked to verify whether a word was correctly or incorrectly spelled to measure analytic processing, as well as to intuitively assess whether sets of three words were coherent (remote associates task) to measure holistic processing. As expected, implicit but not explicit negative affect interacted with low action orientation (“state orientation”) to predict higher d' performance in word spelling, whereas implicit but not explicit positive affect interacted with high action orientation to predict higher d' performance in coherence judgments for word triads. Results are interpreted according to personality systems interaction theory. These findings suggest that affect and affect changes should be measured explicitly and implicitly to investigate affect‐cognition interactions. Moreover, they suggest that good affect regulators benefit from positive affect for holistic processing, whereas bad affect regulators benefit from negative affect for analytical processing.
Draft Genome Sequence of
Colletotrichum acutatum Sensu Lato
(
Colletotrichum fioriniae
)
Authors: Baroncelli Riccardo , Sreenivasaprasad Surapareddy , Sukno Serenella A. , Thon Michael R. , Holub Eric 
Published: April 2014

ABSTRACT

In addition to its economic impact,
Colletotrichum acutatum sensu lato
is an interesting model for molecular investigations due to the diversity of host-determined specialization and reproductive lifestyles within the species complex. The pathogen
Colletotrichum fioriniae
forms part of this species complex and causes anthracnose in a wide range of crops and wild plants worldwide. Some members of this species have also been reported to be entomopathogenic. Here, we report the draft genome sequence of a heterothallic reference isolate of
C. fioriniae
(strain PJ7). This sequence provides a range of new resources that serve as a useful platform for further research in the field.
Complete Genome Sequences of Nitrofurantoin-Sensitive and -Resistant Escherichia coli ST540 and ST2747 Strains
Authors: Xavier Basil Britto , Vervoort Jascha , Stewardson Andrew , Adriaenssens Niels , Coenen Samuel , Harbarth Stephan , Goossens Herman , Malhotra-Kumar Surbhi 
Published: April 2014

ABSTRACT

Widespread multidrug resistance in
Escherichia coli
has necessitated the reintroduction of older antibiotics, such as nitrofurantoin. However, mechanisms by which resistance to nitrofurantoin emerges in
E. coli
are not well elucidated. Toward this aim, we sequenced two nitrofurantoin-sensitive
E. coli
sequence types (ST540 and ST2747) and their four nitrofurantoin-resistant derivatives generated
in vitro
under aerobic and anaerobic growth conditions.
Complete Genome Sequence of Paenibacillus polymyxa SQR-21, a Plant Growth-Promoting Rhizobacterium with Antifungal Activity and Rhizosphere Colonization Ability
Authors: Li Shuqing , Yang Dongqing , Qiu Meihua , Shao Jiahui , Guo Rong , Shen Biao , Yin Xihou , Zhang Ruifu , Zhang Nan , Shen Qirong 
Published: April 2014

ABSTRACT

Here we report the complete genome sequence of a plant growth-promoting rhizobacterium (PGPR),
Paenibacillus polymyxa
SQR-21, which consists of one circular chromosome of 5,828,438 bp with 5,024 coding sequences (CDS). The data presented highlight multiple sets of functional genes associated with its plant-beneficial characteristics.
Draft Genome Sequence of Mycobacterium cosmeticum DSM 44829
Authors: Croce Olivier , Robert Catherine , Raoult Didier , Drancourt Michel 
Published: April 2014

ABSTRACT

We announce the draft genome sequence of
Mycobacterium cosmeticum
strain DSM 44829, a nontuberculous species responsible for opportunistic infection. The genome described here is composed of 6,462,090 bp, with a G+C content of 68.24%. It contains 6,281 protein-coding genes and 75 predicted RNA genes.
Preventing childhood obesity, phase II feasibility study focusing on South Asians: BEACHeS
Authors: Adab Peymané , Pallan Miranda J , Cade Janet , Ekelund Ulf , Barrett Timothy , Daley Amanda , Deeks Jonathan , Duda Joan , Gill Paramjit , Parry Jayne , Bhopal Raj , Cheng K K 
Published: April 2014

ObjectiveTo assess feasibility and acceptability of a multifaceted, culturally appropriate intervention for preventing obesity in South Asian children, and to obtain data to inform sample size for a definitive trial.DesignPhase II feasibility study of a complex intervention.Setting8 primary schools in inner city Birmingham, UK, within populations that are predominantly South Asian.Participants1090 children aged 6–8 years took part in the intervention. 571 (85.9% from South Asian background) underwent baseline measures. 85.5% (n=488) were followed up 2 years later.InterventionsThe 1-year intervention consisted of school-based and family-based activities, targeting dietary and physical activity behaviours. The intervention was modified and refined throughout the period of delivery.Main outcome measuresAcceptability and feasibility of the intervention and of measurements required to assess outcomes in a definitive trial. The difference in body mass index (BMI) z-score between arms was used to inform sample size calculations for a definitive trial.ResultsSome intervention components (increasing school physical activity opportunities, family cooking skills workshops, signposting of local leisure facilities and attending day event at a football club) were feasible and acceptable. Other components were acceptable, but not feasible. Promoting walking groups was neither acceptable nor feasible. At follow-up, children in the intervention compared with the control group were less likely to be obese (OR 0.41; 0.19 to 0.89), and had lower adjusted BMI z-score (−0.15 kg/m2; 95% CI −0.27 to −0.03).ConclusionsThe feasibility study informed components for an intervention programme. The favourable direction of outcome for weight status in the intervention group supports the need for a definitive trial. A cluster randomised controlled trial is now underway to assess the clinical and cost-effectiveness of the intervention.Trial registration numberISRCTN51016370.
Is long-term follow-up of adequately coil-occluded ruptured cerebral aneurysms always necessary? A single-center study of recurrences after endovascular treatment
Authors: Mortimer Alex M , Marsh Hannah , Klimczak Katherine , Joshi Dhiraj , Barton Helena , Nelson Richard J , Bradley Marcus D , Renowden Shelley A 
Published: April 2014

PurposeAneurysm recurrence following coil occlusion is well recognized. However, there is controversy as to how long these patients should be followed up after coiling to detect reopening. We aimed to identify the rate of late reopening and the risk factors for reopening in a large single-center cohort of ruptured aneurysms that appeared adequately occluded at 6 months. We also aimed to assess whether rates of recurrence have altered over time with improving coil and angiographic technology.MethodsPatients treated between 1996 and 2010 were assessed and those with both 6-month initial and subsequent long-term follow-up with either digital subtraction angiography or magnetic resonance angiography were included. Aneurysms were stratified by features such as size, neck width, anatomical location and time of treatment: 1996–2005 (cohort 1) and 2006–2010 (cohort 2). ORs for risk of recurrence were calculated for aneurysm features and rates of recurrence in each cohort were compared using a χ2test.Results437 patients with 458 adequately occluded aneurysms at 6 months had mean long-term follow-up of 31 months; 57 (12.4%) were large (≥10 mm) and 104 (22.7%) were wide-necked (>4 mm). Nine aneurysms (2%) showed significant late anatomical deterioration whereby retreatment was considered or undertaken. The risk was greater for large aneurysms (≥10 mm) (OR 15.61, 95% CI 3.79 to 64.33, p=0.0001) or wide-necked aneurysms (>4 mm) (OR 12.70, 95% CI 2.60 to 62.13, p=0.0017). The frequency of significant late anatomical deterioration and retreatment was also less common in those treated in cohort 2 (p<0.05). No completely occluded aneurysm at 6 months demonstrated significant late recurrence.ConclusionsMost aneurysms adequately occluded at 6 months did not show evidence of late recurrence. Large and wide-neck aneurysms are, however, at greater risk of later recurrence.
Quantitative comparison of hemodynamic parameters from steady and transient CFD simulations in cerebral aneurysms with focus on the aneurysm ostium
Authors: Karmonik C , Diaz O , Klucznik R , Grossman R G , Zhang Y J , Britz G , Lv N , Huang Q 
Published: April 2014

ObjectiveTo quantitatively compare hemodynamics simulated with steady-state and transient computational fluid dynamics (CFD) simulations in cerebral aneurysms with single inflow, with focus at the aneurysm ostium.MethodsTransient and steady-state CFD simulations were performed in 10 cerebral aneurysms. Distributions and average values for pressure, helicity, vorticity, and velocity were qualitatively compared at proximal and distal parent artery locations, at the ostium plane, and in the aneurysm, and scaling factors between the two kinds of simulations were determined. Relative inflow and outflow areas at the ostium were compared, as were average inflow and outflow velocities. In addition, values for the pressure-loss coefficient (PLC), a recently introduced parameter to assess aneurysm rupture risk, were compared for both kinds of simulation.ResultsDistributions of hemodynamic parameters had a similar shape but were lower for transient than for steady-state simulations. Averaged scaling factors over cases and anatomical locations showed differences for hemodynamic parameters (0.485±0.01 for pressure, 0.33±0.02 for helicity, 0.58±0.06 for vorticity and 0.56±0.04 for velocity). Good agreement between ratios of inflow and outflow areas at the aneurysm ostium was obtained (Pearson correlation coefficient >0.97, p<0.001) and for the PLC (linear regression slope 0.73±0.14, R2=0.75).ConclusionsSteady-state simulations are a quick alternative to transient simulation for visualizing and quantifying inflow and outflow areas at the aneurysm ostium, potentially of value when planning flow diverter treatment and for quantifying the PLC, a potential indicator of aneurysm rupture.
Incidence of PR3- and MPO-ANCA autoantibody specificity changes in ANCA-associated vasculitis
Authors: Holding Stephen , Fisher Victoria J , Abuzakouk Mohamed 
Published: April 2014

Background Monitoring of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in remission usually includes indirect immunofluorescence (IIF), proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA. Typically, PR3 and MPO-ANCA are both performed because patients sometimes switch specificity during follow up. Published data are limited to case reports and incidence of change is not reported. The aim of this study was to quantify the incidence of antibody switching. Methods Hull and East Yorkshire Hospitals National Health Service Trust serves a population of 720,000 for ANCA testing. We reviewed all ANCA results from January 2000 to August 2012 to quantify incidence of antibody switching. A total of 22,002 IIF screens (14,518 patients) were performed. A total of 9838 (45%) also had PR3- and MPO-ANCA (6439, 44% of patients). Patients that changed specificity from PR3- to MPO-ANCA and vice versa were identified and case notes reviewed. Results A total of 218 patients with confirmed AAV positive for PR3/MPO-ANCA were followed for a mean of 2.6 years (range <0.1 to 12.4 years; with 113 (52%) patients followed for >1 year). Five patients (2%) changed specificity during follow up (3 GPA, 1 MPA & 1 EGPA). In two patients this was associated with relapse. Incidence of specificity change was 1 per 82 years (including two reversions to presenting specificity) and one per 286 years for changes associated with relapse. Monitoring using only the initial antibody specificity would have resulted in missed relapse in one patient. Conclusion Antibody specificity changes in AAV are rare. Monitoring only the initial antibody specificity would have missed clinical events but rising C-reactive protein presaged relapse in these cases.
One siRNA pool targeting the λ constant region stops λ light-chain production and causes terminal endoplasmic reticulum stress
Authors: Zhou Ping , Ma Xun , Iyer Lakshmanan , Chaulagain Chakra , Comenzo Raymond L. 
Published: April 2014

Key PointsImmunoglobulin light-chain and antibody production by plasma cells is significantly reduced by siRNA for the light-chain constant region. In plasma cells making intact antibodies, knockdown of light chains can cause terminal ER stress because of unpaired heavy chains.
A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias
Authors: Dubrovsky Leonid , Pankov Dmitry , Brea Elliott Joseph , Dao Tao , Scott Andrew , Yan Su , O’Reilly Richard J , Liu Cheng , Scheinberg David A. 
Published: April 2014

Key PointsThis study shows the effective anticancer activity of a T-cell receptor mimic antibody targeting WT1 in resistant human Ph+ ALL. In combination with tyrosine kinase inhibitors, ESKM can result in cure of Ph+ ALL in murine models.
No correlation between minimal electrical charge at the tip of the stimulating catheter and the efficacy of the peripheral nerve block catheter for brachial plexus block: a prospective blinded cohort study
Authors: Schoenmakers Karin PW , Heesterbeek Petra JC , Jack Nigel TM , Stienstra Rudolf 
Published: April 2014

Abstract

Background
Stimulating catheters offer the possibility of delivering an electrical charge via the tip of the catheter. This may be advantageous as it allows verifying if the catheter tip is in close proximity to the target nerve, thereby increasing catheter performance. This prospective blinded cohort study was designed to investigate whether there is a correlation between the minimal electrical charge at the tip of the stimulating catheter, and the efficacy of the peripheral nerve block (PNB) catheter as determined by 24 h postoperative morphine consumption.

Methods
Forty adult patients with ASA physical health classification I-III scheduled for upper extremity surgery under combined continuous interscalene block and general anesthesia were studied. Six patients were excluded from analysis.
After inserting a stimulating catheter as if it were a non-stimulating catheter for 2–5 cm through the needle, the minimal electrical charge necessary to obtain an appropriate motor response was determined. A loading dose of 20 mL ropivacaine 0.75% ropivacaine was then administered, and postoperative analgesia was provided by a continuous infusion of ropivacaine 0.2% 8 mL.h-1 via the brachial plexus catheter, and an intravenous morphine patient-controlled analgesia (PCA) device.
Main outcome measures include the minimal electrical charge (MEC) at the tip of the stimulating catheter necessary to elicit an appropriate motor response, and the efficacy of the PNB catheter as determined by 24 h postoperative PCA morphine consumption.

Results
Mean (SD) [range] MEC at the tip of the stimulating catheter was 589 (1414) [30 – 5000] nC. Mean (SD) [range] 24 h morphine consumption was 8.9 (9.9) [0–29] mg. The correlation between the MEC and 24 h postoperative morphine consumption was Spearman’s Rho rs = -0.26, 95% CI -0.56 to 0.09.

Conclusion
We conclude that there is no proportional relation between MEC at the tip of the blindly inserted stimulating catheter and 24 h postoperative morphine consumption.

Trial registration
Trialregister.nl identifier: NTR2328
Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and observational studies
Authors: Wan You-Dong , Sun Tong-Wen , Kan Quan-Cheng , Guan Fang-Xia , Zhang Shu-Guang 
Published: April 2014

Abstract
Introduction
Observational data have suggested that statin therapy may reduce mortality in patients with infection and sepsis; however, results from randomized studies are contradictory and do not support the use of statins in this context. Here, we performed a meta-analysis to investigate the effects of statin therapy on mortality from infection and sepsis.

Methods
We searched electronic databases (PubMed and Embase) for articles published before November 2013. Randomized or observational studies reporting the effects of statin therapy on mortality in patients with infection or sepsis were eligible. Randomized and observational studies were separately pooled with relative risks (RRs) and random-effects models.

Results
We examined 5 randomized controlled trials with 867 patients and 27 observational studies with 337,648 patients. Among the randomized controlled trials, statins did not significantly decrease in-hospital mortality (RR, 0.98; 95% confidence interval (CI), 0.73 to 1.33) or 28-day mortality (RR, 0.93; 95% CI, 0.46 to 1.89). However, observational studies indicated that statins were associated with a significant decrease in mortality with adjusted data (RR, 0.65; 95% CI, 0.57 to 0.75) or unadjusted data (RR, 0.74; 95% CI, 0.59 to 0.94).

Conclusions
Limited evidence suggests that statins may not be associated with a significant reduction in mortality from infection and sepsis. Although meta-analysis from observational studies showed that the use of statins was associated with a survival advantage, these outcomes were limited by high heterogeneity and possible bias in the data. Therefore, we should be cautious about the use of statins in infection and sepsis.
Book Reviews
Authors: Courtois Cédric , Given Jock , Picard Robert G. 
Published: April 2014

Abstract
The Social Use of Media, Helena Bilandzic, Geoffroy Patriarche and Paul Traudt (eds) (2012) Bristol/Chicago: Intellect, 202 pp., ISBN: 9781841505121, p/bk, £25
Shut-Off: the Canadian Digital Television Transition, Gregory Taylor (2013) Montreal: McGill-Queen’s University Press, 232 pp., ISBN: 9780773540491, p/bk, $29.95
Private Television in Western Europe: Content, Markets, Policies, Karen Donders, Caroline Pauwels and Jan Loisen (eds) (2013) Basingstoke: Palgrave Macmillan, 296 pp., ISBN: 9782248027543, h/bk, £55
Treatment of basal cell carcinoma using a combination of pulsed dye laser and imiquimod – Case report and review
Authors: Gaitanis Georgios , Ikiades Aris , Bassukas Ioannis D. 
Published: April 2014

AbstractObjective:To evaluate the feasibility and efficacy of a pulsed dye laser (PDL) during a 5-week course of 5% topical imiquimod application in a patient with a nodular basal cell carcinoma (BCC) and to review the literature for data on PDL treatment of BCC.Methods:A 74-year-old patient with a 7-mm biopsy-proven BCC on his nose was treated with topical daily imiquimod for 2 weeks. Subsequently a laser session was performed with a flash lamp-pumped dye laser at 595 nm (Dermobeam 2000; Deka M.E.L.A., Florence, Italy) employing one pass with the following parameters: fluence 15 J/cmResults:Topical imiquimod was continued for a further 3 weeks after the PDL session with a minimal increase in irritation. The tumor cleared and there has been no recurrence for 12 months. The literature search revealed a total of 7 small studies that included 120 tumors, the majority treated with a 595-nm device (104/120). Overall 81/120 (67.5%) treated tumors have been assessed as complete responders. No differences were recorded in relapse rates in association with the localization of the tumor, the histology (superficial vs. non-superficial), the wavelength of the device employed (595 vs. 585 nm), or the application of dynamic cooling. From the treatment parameters, only the use of multiple vs. single PDL sessions affected the outcome favorably (Conclusion:The combination of PDL with imiquimod could be a promising approach for the treatment of BCC and should be further evaluated in future studies.
An energy-based equivalent inclusion for the determination of nanocomposite behavior
Authors: Maalej Yamen , Dormieux Luc , Lemarchand Eric 
Published: April 2014

Abstract
Achieving remarkable mechanical properties for very low levels of reinforcement, nanocomposites are nowadays a new class of materials with high potential. Thanks to the stiffening aspect of the interface region between the matrix and the inclusions, nanocomposites often exhibit improved mechanical and physical properties compared to the conventional composites reinforced with micron-sized particles. This paper presents a strategy based on the introduction of an equivalent inclusion phase that allows managing the ellipsoidal morphology of inhomogeneous inclusion nanophase in the determination of estimates for the homogenized elastic moduli. Application to clay-polymer nanocomposites is presented in the framework of the dilute scheme. The latter gives theoretical estimates in good agreement with experimental results reported in the literature.