bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are repeated assisted reproductive technology treatments and an unsuccessful outcome risk factors for unipolar depression in infertile women?
Authors: Sejbaek Camilla S. , Pinborg Anja , Hageman Ida , Forman Julie L. , Hougaard Charlotte Ø. , Schmidt Lone 
Published: August 2015

AbstractIntroductionPrevious studies have shown conflicting results as to whether unsuccessful medically assisted reproduction is a risk factor for depression among women. This study therefore investigated if women with no live birth after assisted reproductive technology (ART) treatment had a higher risk of unipolar depression compared with women with a live birth after ART treatment.Material and methodsThe Danish National ART‐Couple (DANAC) Cohort is a national register‐based cohort study that consists of women who received ART treatment from 1 January 1994 to 30 September 2009, in Denmark (n = 41 050). Information on unipolar depression was obtained from the Danish Psychiatric Central Research Register. The analyses were conducted in Cox regression analysis.ResultsDuring the 308 494 person‐years of follow up, 552 women were diagnosed with unipolar depression. A Cox proportional hazards model showed that women in ART treatment, with no live birth yet, had a lower risk of unipolar depression compared with women with a live birth. Women had the highest risk of unipolar depression 0–42 days after a live birth (adjusted hazard ratio 5.08, 95% CI 3.11–8.29) compared with women with no live birth. A lower, but still increased, risk of unipolar depression, was found in women 43 days to 1 year and >1 year after a live birth compared with women with no live birth yet.ConclusionsMotherhood is an important trigger of unipolar depression in women conceiving after ART treatment.
The capacity of mid‐pregnancy cervical length to predict preterm birth in low‐risk women: a national cohort study
Authors: van der Ven Jeanine , van Os Melanie A. , Kazemier Brenda M. , Kleinrouweler Emily , Verhoeven Corine J. , de Miranda Esteriek , van Wassenaer‐Leemhuis Aleid G. , Kuiper Petra N. , Porath Martina , Willekes Christine , Woiski Mallory D. , Sikkema Marko J. , Roumen Frans J.M.E. , Bossuyt Patrick M. , Haak Monique C. , de Groot Christianne J.M. , Mol Ben W.J. , Pajkrt Eva 
Published: August 2015

AbstractIntroductionWe investigated the predictive capacity of mid‐trimester cervical length (CL) measurement for spontaneous and iatrogenic preterm birth.Material and methodsWe performed a prospective observational cohort study in nulliparous women and low‐risk multiparous women with a singleton pregnancy between 16+0 and 21+6 weeks of gestation. We assessed the prognostic capacity of transvaginally measured mid‐trimester CL for spontaneous and iatrogenic preterm birth (<37 weeks) using likelihood ratios (LR) and receiver‐operating‐characteristic analysis. We calculated numbers needed to screen to prevent one preterm birth assuming different treatment effects. Main outcome measures were preterm birth <32, <34 and <37 weeks.ResultsWe studied 11 943 women, of whom 666 (5.6%) delivered preterm: 464 (3.9%) spontaneous and 202 (1.7%) iatrogenic. Mean CL was 44.1 mm (SD 7.8 mm). In nulliparous women, the LRs for spontaneous preterm birth varied between 27 (95% CI 7.7–95) for a CL ≤ 20 mm, and 2.0 (95% CI 1.6–2.5) for a CL between 30 and 35 mm. For low‐risk multiparous women, these LRs were 37 (95% CI 7.5–182) and 1.5 (95% CI 0.97–2.2), respectively. Using a cut‐off for CL ≤ 30 mm, 28 (6.0%) of 464 women with spontaneous preterm birth were identified. The number needed to screen to prevent one case of preterm birth was 618 in nulliparous women and 1417 for low‐risk multiparous women (40% treatment effect, cut‐off 30 mm).ConclusionIn women at low risk of preterm birth, CL predicts spontaneous preterm birth. However, its isolated use as a screening tool has limited value due to low sensitivity.
Less severe cerebral palsy outcomes in infants treated with therapeutic hypothermia
Authors: Jary Sally , Smit Elisa , Liu Xun , Cowan Frances M. , Thoresen Marianne 
Published: August 2015

AbstractAimTo describe the incidence, type and severity of cerebral palsy at 24 months in a regional cohort of infants treated with whole‐body therapeutic hypothermia for neonatal encephalopathy.MethodsData were collected prospectively in a regional centre providing TH. Antenatal and perinatal clinical variables and severity of encephalopathy were collected. Infants were assessed at 18 months using the Bayley Scales of Infant and Toddler Development‐III, and the presence and severity of CP was investigated at 24 months.ResultsA total of 125 of 132 infants fulfilled entry criteria for TH trials and completed 72 h of TH. Sixteen (13%) of the 125 infants died, and eight (6%) were not available for follow‐up. Eighteen infants (14%; 18% of those assessed) developed CP. Of these, 12 (67%) were classified using the Gross Motor Function Classification System, at level 1, six (33%) at level 5 and none at levels 2, 3 or 4.ConclusionOur regional clinical cohort had lower mortality and comparable rates of CP compared with historical outcomes in TH trials. In contrast to historical cohorts, only one‐third of the 18 children with CP were severely affected and 12 were mildly affected, all of whom were independently ambulant by 24 months.
Handling Missing Data in Matched Case-Control Studies Using Multiple Imputation
Authors: Seaman Shaun R. , Keogh Ruth H. 
Published: August 2015

Summary
Analysis of matched case-control studies is often complicated by missing data on covariates. Analysis can be restricted to individuals with complete data, but this is inefficient and may be biased. Multiple imputation (MI) is an efficient and flexible alternative. We describe two MI approaches. The first uses a model for the data on an individual and includes matching variables; the second uses a model for the data on a whole matched set and avoids the need to model the matching variables. Within each approach, we consider three methods: full-conditional specification (FCS), joint model MI using a normal model, and joint model MI using a latent normal model. We show that FCS MI is asymptotically equivalent to joint model MI using a restricted general location model that is compatible with the conditional logistic regression analysis model. The normal and latent normal imputation models are not compatible with this analysis model. All methods allow for multiple partially-observed covariates, non-monotone missingness, and multiple controls per case. They can be easily applied in standard statistical software and valid variance estimates obtained using Rubin's Rules. We compare the methods in a simulation study. The approach of including the matching variables is most efficient. Within each approach, the FCS MI method generally yields the least-biased odds ratio estimates, but normal or latent normal joint model MI is sometimes more efficient. All methods have good confidence interval coverage. Data on colorectal cancer and fibre intake from the EPIC-Norfolk study are used to illustrate the methods, in particular showing how efficiency is gained relative to just using individuals with complete data.
Inclusion or Dualization? The Political Economy of Employment Relations in Italian and Greek Telecommunications
Authors: Kornelakis Andreas 
Published: August 2015

AbstractRecent literature argues that trade unions in restructuring service industries have responded to the challenges of the post‐industrial era by accepting different forms of labour market dualization. This article examines two case studies from Italy and Greece, in which unions adopted divergent responses to intensified market pressures unleashed by the liberalization of national telecommunications markets. In the Italian case, collective bargaining was successfully centralized, resulting in the inclusion of traditional labour market ‘outsiders’. In contrast, bargaining centralization failed in Greek telecommunications, leading to intensified dualization. These different paths of institutional change are explained as resulting from differences in ideological cleavages among unions and distinct legacies in employers’ associations.
The detrital record of late‐Miocene to Pliocene surface uplift and exhumation of the Venezuelan Andes in the Maracaibo and Barinas foreland basins
Authors: Bermúdez M. A. , Hoorn C. , Bernet M. , Carrillo E. , van der Beek P. A. , Garver J. I. , Mora J. L. , Mehrkian K. 
Published: August 2015

AbstractA multidisciplinary approach, combining sediment petrographic, palynological and thermochronological techniques, has been used to study the Miocene‐Pliocene sedimentary record of the evolution of the Venezuelan Andes. Samples from the Maracaibo (pro‐wedge) and Barinas (retro‐wedge) foreland basins, proximal to this doubly vergent mountain belt, indicate that fluvial and alluvial‐fan sediments of similar composition were shed to both sides of the Venezuelan Andes. Granitic and gneissic detritus was derived from the core of the mountain belt, whereas sedimentary cover rocks and uplifted foreland basin sediments were recycled from its flanks. Palynological evidence from the Maracaibo and Barinas basins constrains depositional ages of the studied sections from late Miocene to Pliocene. The pollen assemblages from the Maracaibo Basin are indicative of mountain vegetation, implying surface elevations of up to 3500–4000 m in the Venezuelan Andes at this time. Detrital apatite fission‐track (AFT) data were obtained from both stratigraphic sections. In samples from the Maracaibo basin, the youngest AFT grain‐age population has relatively static minimum ages of 5 ± 2 Ma, whereas for the Barinas basin samples AFT minimum ages are 7 ± 2 Ma. With exception of two samples collected from the Eocene Pagüey Formation and from the very base of the Miocene Parángula Formation, no evidence for resetting and track annealing in apatite due to burial heating in the basins was found. This is supported by rock‐eval analyses on organic matter and thermal modelling results. Therefore, for all other samples the detrital AFT ages reflect source area cooling and impose minimum age constraints on sediment deposition. The main phase of surface uplift, topography and relief generation, and erosional exhumation in the Venezuelan Andes occurred during the late Miocene to Pliocene. The Neogene evolution of the Venezuelan Andes bears certain similarities with the evolution of the Eastern Cordillera in Colombia, although they are not driven by exactly the same underlying geodynamic processes. The progressive development of the two mountain belts is seen in the context of collision of the Panama arc with northwestern South America and the closure of the Panama seaway in Miocene times, as well as contemporaneous movement of the Caribbean plate to the east and clock‐wise rotation of the Maracaibo block.
Additional skin biopsy could widen the diagnostic window of vasculitic neuropathy
Authors: Kanda Takashi 
Published: August 2015

AbstractA substantial percentage of vasculitic neuropathy patients remain undiagnosed, even after combined nerve/muscle biopsy. In Masuda's article in this issue of the journal, the addition of a simultaneous skin biopsy yielded a mere 12% increase in the diagnostic accuracy; however, this procedure is worth considering because of its non‐invasive nature, and future detailed morphological analyses of biopsied skin specimens might further widen the diagnostic window of vasculitic neuropathy.
A Novel Approach to Measuring Efficiency of Scientific Research Projects: Data Envelopment Analysis
Authors: Dilts David M. , Zell Adrienne , Orwoll Eric 
Published: August 2015

AbstractPurposeMeasuring the efficiency of resource allocation for the conduct of scientific projects in medical research is difficult due to, among other factors, the heterogeneity of resources supplied (e.g., dollars or FTEs) and outcomes expected (e.g., grants, publications). While this is an issue in medical science, it has been approached successfully in other fields by using data envelopment analysis (DEA). DEA has a number of advantages over other techniques as it simultaneously uses multiple heterogeneous inputs and outputs to determine which projects are performing most efficiently, referred to as being at the efficiency frontier, when compared to others in the data set.MethodThis research uses DEA for the evaluation of supported translational science projects by the Oregon Clinical and Translational Research Institute (OCTRI), a NCATS Clinical & Translational Science Award (CTSA) recipient.ResultsThese results suggest that the primary determinate of overall project efficiency at OCTRI is the amount of funding, with smaller amounts of funding providing more efficiency than larger funding amounts.ConclusionThese results, and the use of DEA, highlight both the success of using this technique in helping determine medical research efficiency and those factors to consider when distributing funds for new projects at CTSAs.
Severe Aortic Regurgitation Caused by Unicuspid Aortic Valve Based on Quadricuspid Aortic Valve
Authors: Dokuni Kumiko , Tanaka Hidekazu , Mochizuki Yasuhide , Matsumoto Kensuke , Okita Yutaka , Hirata Ken‐ichi 
Published: August 2015

Mini‐AbstractA 41‐year‐old man was admitted to our hospital because of shortness of breath. Two‐dimensional transesophageal echocardiography revealed the presence of a horseshoe‐shaped unicuspid aortic valve (UAV) with two raphes at 4 and 8 o'clock positions of the aortic leaflet, and prolapse of the noncoronary cusp. Three‐dimensional transesophageal echocardiography (3DTEE) clearly showed UAV, and another raphe was observed at the 7 o'clock position of the aortic leaflet. The Bentall procedure was performed, and surgical inspection confirmed the diagnosis of UAV based on the quadricuspid aortic valve. The excised specimen of the aortic valve was remarkably similar to the findings of 3DTEE.
Functional lateralization of temporoparietal junction – imitation inhibition, visual perspective‐taking and theory of mind
Authors: Santiesteban Idalmis , Banissy Michael J. , Catmur Caroline , Bird Geoffrey 
Published: August 2015

AbstractAlthough neuroimaging studies have consistently identified the temporoparietal junction (TPJ) as a key brain region involved in social cognition, the literature is far from consistent with respect to lateralization of function. For example, during theory‐of‐mind tasks bilateral TPJ activation is found in some studies but only right hemisphere activation in others. Visual perspective‐taking and imitation inhibition, which have been argued to recruit the same socio‐cognitive processes as theory of mind, are associated with unilateral activation of either left TPJ (perspective taking) or right TPJ (imitation inhibition). The present study investigated the functional lateralization of TPJ involvement in the above three socio‐cognitive abilities using transcranial direct current stimulation. Three groups of healthy adults received anodal stimulation over right TPJ, left TPJ or the occipital cortex prior to performing three tasks (imitation inhibition, visual perspective‐taking and theory of mind). In contrast to the extant neuroimaging literature, our results suggest bilateral TPJ involvement in imitation inhibition and visual perspective‐taking, while no effect of anodal stimulation was observed on theory of mind. The discrepancy between these findings and those obtained using neuroimaging highlight the efficacy of neurostimulation as a complementary methodological tool in cognitive neuroscience.
A new piezoelectric fatigue testing machine in pure torsion for ultrasonic gigacycle fatigue tests: application to forged and extruded titanium alloys
Authors: Nikitin A. , Bathias C. , Palin‐Luc T. 
Published: August 2015

AbstractThis article briefly discusses the history of the development of ultrasonic fatigue testing methods, with respect to industrial needs. The development of ultrasonic techniques and the progress made in the computer industry have led to improvements in ultrasonic testing techniques. It has been shown, that existing ultrasonic testing systems have limitations that lead to the need for a new ultrasonic fatigue testing machine operating in pure torsion. This paper introduces the development of a new piezoelectric machine working in the continuous regime (i.e. without pulse‐pause). This machine has been used to investigate the Very High Cycle Fatigue (VHCF) properties of the VT3‐1 alpha beta aeronautical titanium alloy (which is similar to Ti–6Al–4V) produced by two manufacturing processes: forging and extrusion. The extruded titanium alloy has a higher VHCF strength in torsion compared to the forged one. Despite the maximum shear stress occurring at the specimen surface under torsion loading, internal fatigue crack initiation can be observed in both the forged and extruded alloys.
The interacting effects of food, spring temperature, and global climate cycles on population dynamics of a migratory songbird
Authors: Townsend Andrea K. , Cooch Evan G. , Sillett T. Scott , Rodenhouse Nicholas L. , Holmes Richard T. , Webster Michael S. 
Published: August 2015

AbstractAlthough long‐distance migratory songbirds are widely believed to be at risk from warming temperature trends, species capable of attempting more than one brood in a breeding season could benefit from extended breeding seasons in warmer springs. To evaluate local and global factors affecting population dynamics of the black‐throated blue warbler (Setophaga caerulescens), a double‐brooded long‐distance migrant, we used Pradel models to analyze 25 years of mark–recapture data collected in New Hampshire, USA. We assessed the effects of spring temperature (local weather) and the El Niño Southern Oscillation index (a global climate cycle), as well as predator abundance, insect biomass, and local conspecific density on population growth in the subsequent year. Local and global climatic conditions affected warbler populations in different ways. We found that warbler population growth was lower following El Niño years (which have been linked to poor survival in the wintering grounds and low fledging weights in the breeding grounds) than La Niña years. At a local scale, populations increased following years with warm springs and abundant late‐season food, but were unaffected by spring temperature following years when food was scarce. These results indicate that the warming temperature trends might have a positive effect on recruitment and population growth of black‐throated blue warblers if food abundance is sustained in breeding areas. In contrast, potential intensification of future El Niño events could negatively impact vital rates and populations of this species.
The quality of organic matter shapes the functional biogeography of bacterioplankton across boreal freshwater ecosystems
Authors: Ruiz‐González Clara , Niño‐García Juan Pablo , Lapierre Jean‐François , del Giorgio Paul A. 
Published: August 2015

AbstractAimThe need to go beyond taxonomy to understand patterns in microbial function has led to an increased use of trait‐based approaches, yet we know little about how microbial functional traits vary across large‐scale environmental gradients in natural ecosystems. Here, we apply a trait‐based approach to explore the large‐scale variability in the trait structure underlying the processing of dissolved organic matter (DOM) by boreal bacterioplankton communities, as well as its regulation and links to taxonomic composition.LocationSamples were collected from 296 rivers and lakes across five regions in northern Quebec (Canada), which span large gradients in environmental, climatic and geographical properties typical of the boreal zone.MethodsWe used the metabolic profiles obtained with Biolog EcoPlates® as an imprint of the trait structure underlying bacterial processing of DOM, and Illumina sequencing of the 16SrRNA gene to characterize the taxonomic composition of these bacterial assemblages. The resulting spatial patterns were compared with an array of climatic, landscape and limnological properties varying at the landscape scale.ResultsDespite a clear regional segregation of the sampled sites based on environmental variables, the trait structure of boreal bacteria did not show any regional or ecosystem‐specific patterns, but rather was linked to a gradient of quality of DOM. Community trait configurations diverged progressively with decreasing terrestrial influence, probably due to local processes that transform and diversify the available pool of DOM. This DOM quality gradient did not explain the taxonomic biogeography of these communities, which was controlled by a different set of environmental factors.Main conclusionsThe functional biogeography of boreal bacterioplankton is driven by the nature of the DOM pool, and particularly by the influence of terrestrial DOM. The lack of coherence between functional and taxonomic biogeographies implies that the environmental controls of freshwater bacterial performance cannot be directly inferred from spatial patterns in taxonomic composition.
Case Report of Debilitating Headaches and a Coexisting Ophthalmic Artery Aneurysm: An Indication for Treatment?
Authors: Baron Eric P. , Hui Ferdinand K. , Kriegler Jennifer S. 
Published: August 2015

ObjectiveWe present a case of a patient who had severe unilateral headaches related to a small, unruptured ophthalmic artery aneurysm, who experienced complete headache cessation following endovascular coiling.BackgroundSmall unruptured intracranial aneurysms are generally managed and followed conservatively due to minimal risk of rupture. Headaches are frequently reported in patients with intracranial aneurysms, but these aneurysms are typically considered incidental and unrelated, given the undefined association between headaches and most aneurysms.ConclusionThere may be some unruptured intracranial aneurysms that can cause intractable headaches and warrant interventional treatment. Future prospective studies are needed that compare pre‐ and post‐procedure headache character and diagnosis, aneurysm characteristics such as size, location, orientation, and shape, type of aneurysm repair with materials used, and other potential risk factors for worsening post‐procedure headache in order to better predict headache association to aneurysms, as well as outcomes following endovascular aneurysm treatment.