bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiplierless filter‐bank based multicarrier system by using canonical signed digit representation
Authors: Aliasgari Mohammad , Marghi Yeganeh M. , Baharani Mohammadreza , Fakhraie Sied Mehdi 
Published: October 2014

ABSTRACTThe filter‐bank based multicarrier (FBMC) system is a candidate for designing the physical layer of a cognitive radio because of its spectral efficiency and the spectral containment. The main drawback of such a system compared with orthogonal frequency division multiplexing systems is its high computation complexity, because each subcarrier is shaped by a non‐rectangular prototype filter. Although poly‐phase decomposition is suggested to decrease the sampling rate of filtering, the number of filtering operations (multiplications) is dramatically increased by the growing number of subcarriers and the amount of the desired spectral containment. Hence, hardware implementation of the FBMC system faces challenges such as high electrical power consumption and large silicon area occupation. In order to reduce computational complexity, a multiplierless filter design based on the canonical signed digit (CSD) representation is proposed. In this technique, at first, a prototype filter is designed. Then a pre‐optimization step is employed to adapt the prototype filter coefficients to system objectives and produce an enriched initial seed for genetic algorithm (GA) optimization. Finally, a customized GA is employed to jointly optimize and synthesize filter coefficients into the finite precision CSD representation so that the system objectives such as intersymbol‐interference, interchannel‐interference, and stop‐band attenuation remain unchanged against the full‐precision representation of coefficients. Copyright © 2014 John Wiley & Sons, Ltd.
Preparation, Structural, Thermogravimetric and Spectroscopic Study of Magnesium Potassium Arsenate Hexahydrate
Authors: Abdija Zuldjevat , Najdoski Metodija , Koleva Violeta , Runčevski Tomče , Dinnebier Robert E. , Šoptrajanov Bojan , Stefov Viktor 
Published: October 2014

AbstractThe crystal structure of magnesium potassium arsenate hexahydrate, MgKAsO4·6H2O, was refined from powder diffraction data. MgKAsO4·6H2O crystallizes in the orthorhombic space group Pmn21 with Z = 2, as the biomineral struvite. Complete dehydration of MgKAsO4·6H2O proceeds in a single step, with one endothermic peak at 87.9 °C (Tonset). The infrared and Raman spectra of protiated and deuterated polycrystalline samples were recorded at room temperature and at the boiling temperature of liquid nitrogen (LNT). The assignments of the observed bands are proposed and spectra‐structure correlations are made.
Crystal Structures of Homoleptic Propynyloargentates AI[Ag(C3H3)2] with AI = Ag, Li, Na Solved and Refined from X‐ray Powder Diffraction Data
Authors: Pak Leo , Zibrowius Bodo , Lumeij Marck‐Willem , Dronskowski Richard , Ruschewitz Uwe 
Published: October 2014

AbstractThe crystal structures of three isostructural homoleptic propynyloargentates, namely Ag[Ag(C3H3)2], Li[Ag(C3H3)2], and Na[Ag(C3H3)2] were solved and refined from laboratory X‐ray powder diffraction data (Iba2, Z = 4). Almost linear [H3C–C≡C···Ag···C≡C–CH3]– anions are found: The alkali metal cations or the second silver cation coordinate side‐on to the C≡C triple bond of the alkyne ligand (CN = 8) so that layer‐like structural fragments are formed, which are stacked in an AB fashion along [100]. These crystal structures are corroborated by IR and solid‐state NMR spectra. Powder SHG measurements confirm the acentric space group Iba2. On the other hand, these methods also supported a first structural model obtained earlier, in which very unusual bent [Ag(CCCH3)2]– units were found in a smaller unit cell (Amm2, Z = 2). Bond‐analytical COHP calculations clearly indicate that this structural motif cannot be stable. A close re‐inspection of the diffraction data, now also including high‐resolution synchrotron powder diffraction data (HASYLAB, beamline B2), reveal the existence of one weak additional reflection indicating a larger unit cell. Hence, this investigation clearly shows that under very specific circumstances – e.g. ligands with a weak scattering power compared to the central metal ion – wrong structural models can be obtained from X‐ray powder diffraction data, even when additional information from complementary spectroscopic methods is taken into account. Additional electronic‐structure calculations are therefore needed to elucidate the correct structural arrangement.
Resuscitative Thoracotomy in Penetrating Trauma
Authors: Fairfax Lindsay M. , Hsee Li , Civil Ian D. 
Published: October 2014

Abstract:The resuscitative thoracotomy (RT) is an important procedure in the management of penetrating trauma. As it is performed only in patients with peri‐arrest physiology or overt cardiac arrest, survival is low. Experience is also quite variable depending on volume of penetrating trauma in a particular region. Survival ranges from 0 % to as high as 89 % depending on patient selection, available resources, and location of RT (operating or emergency rooms). In this article, published guidelines are reviewed as well as outcomes. Technical considerations of RT and well as proper training, personnel, and location are also discussed.
Assessment of Hydrogeochemical Processes in a Coastal Region: Application of Multivariate Statistical Model
Authors: Rao N. Subba , Vidyasagar G. , Rao P. Surya , Bhanumurthy P. 
Published: October 2014

Abstract:
Hydrogeochemical studies have been carried out in a coastal region, using multivariate statistical model, for better understanding the controlling processes that influence the aquifer chemistry. Two principal components (PC1 and PC2) are extracted from the data set of chemical variables (pH, TDS, Ca2+, Mg2+, Na+, K+, HCO3−, Cl−, SO42−, NO3− and F−), which account for 79% of the total variation in the quality of groundwater. The PC1 (salinity controlled process) includes the concentrations of TDS, Mg2+, Na+, K+, Cl−, SO42− and NO3−, while the PC2 (alkalinity controlled process) comprises the concentrations of pH, HCO3− and F−. The spatial distribution of PC scores identifies the locations of high salinity and alkalinity processes. The first process corresponds to the influences of geogenic, anthropogenic and marine sources, and the second one to the influence of water-soil-rock interaction. Thus, the present study shows the usefulness of multivariate statistical model as an effective means of interpretation of spatial controlling processes of groundwater chemistry.
Chronology and Ecology of Late Pleistocene Megafauna in the Northern Willamette Valley, Oregon
Authors: Gilmour Daniel M. , Butler Virginia L. , O'Connor Jim E. , Davis Edward Byrd , Culleton Brendan J. , Kennett Douglas J. , Hodgins Gregory 
Published: October 2014

AbstractSince the mid-19th century, western Oregon's Willamette Valley has been a source of remains from a wide variety of extinct megafauna. Few of these have been previously described or dated, but new chronologic and isotopic analyses in conjunction with updated evaluations of stratigraphic context provide substantial new information on the species present, timing of losses, and paleoenvironmental conditions. Using subfossil material from the northern valley, we use AMS radiocarbon dating, stable isotope (δ13C and δ15N) analyses, and taxonomic dietary specialization and habitat preferences to reconstruct environments and to develop a local chronology of events that we then compare with continental and regional archaeological and paleoenvironmental data. Analysis of twelve bone specimens demonstrates the presence of bison, mammoth, horse, sloth, and mastodon from ~ 15,000–13,000 cal yr BP. The latest ages coincide with changing regional climate corresponding to the onset of the Younger Dryas. It is suggested that cooling conditions led to increased forest cover, and along with river aggradation, reduced the area of preferred habitat for the larger bodied herbivores, which contributed to the demise of local megafauna. Archaeological evidence for megafauna–human interactions in the Pacific Northwest is scarce, limiting our ability to address the human role in causing extinction.
On a random time series analysis valid for arbitrary spectral shape
Authors: Janssen Peter A. E. M. 
Published: October 2014

AbstractWhile studying the problem of predicting freak waves it was realized that it would be advantageous to introduce a simple measure for such extreme events. Although it is customary to characterize extremes in terms of wave height or its maximum it is argued in this paper that wave height is an ill-defined quantity in contrast to, for example, the envelope of a wave train. Also, the last measure has physical relevance, because the square of the envelope is the potential energy of the wave train. The well-known representation of a narrow-band wave train is given in terms of a slowly varying envelope function ${\it\rho}$ and a slowly varying frequency ${\it\omega}=-\partial {\it\phi}/\partial t$ where ${\it\phi}$ is the phase of the wave train. The key point is now that the notion of a local frequency and envelope is generalized by also applying the same definitions for a wave train with a broad-banded spectrum. It turns out that this reduction of a complicated signal to only two parameters, namely envelope and frequency, still provides useful information on how to characterize extreme events in a time series. As an example, for a linear wave train the joint probability distribution of envelope height and period is obtained and is validated against results from a Monte Carlo simulation. The extension to the nonlinear regime is, as will be seen, fairly straightforward.
Analytic Approximate Solutions and Numerical Results for Stagnation Point Flow of Jeffrey Fluid Towards an Off-Centered Rotating Disk
Authors: Khan N. A. , Khan S. , Riaz F. 
Published: October 2014

AbstractThe present paper studies the three-dimensional, off centered stagnation flow of a Jeffrey fluid over a rotating disk. The governing non-linear equations and their associated boundary conditions are transformed into coupled ordinary differential equations by utilizing an appropriate similarity transformation. Homotopy analysis method is utilized to evaluate the analytical solution in the form of infinite series. Also, the convergence region of the obtained solution is determined and plotted. The effects of pertaining parameters on radial, azimuthal and induced velocities of the fluid flow are presented graphically and discussed. Moreover comparisons have also been made with the previous results as a special case.
Taxonomic delimitation of the genera Bryoria and Sulcaria, with a new combination Sulcaria spiralifera introduced
Authors: MYLLYS Leena , VELMALA Saara , LINDGREN Hanna , GLAVICH Doug , CARLBERG Tom , WANG Li-Song , GOWARD Trevor 
Published: October 2014

AbstractBryoria pseudocapillaris and B. spiralifera are currently treated as members of Bryoria section Implexae although conspicuous, long and depressed pseudocyphellae characterizing both species resemble those found in the genus Sulcaria. Both genera belong in Parmeliaceae and form an alectorioid group together with Alectoria, Gowardia and Pseudephebe. Parsimony and Bayesian analyses of ITS, partial GAPDH and partial Mcm7 sequence data were used to examine the phylogenetic position of B. pseudocapillaris and B. spiralifera, and in light of these results evaluate the generic delimitation of Bryoria and Sulcaria. A total of 110 specimens of 53 species containing representatives from alectorioid and closely related genera were included in the analyses. The results clearly show first, that both B. pseudocapillaris and B. spiralifera belong in Sulcaria rather than in Bryoria, and second, that they should be considered conspecific. Bryoria pseudocapillaris is proposed as a synonym under B. spiralifera and the name Sulcaria spiralifera comb. nov. is introduced.
Three new Diorygma (Graphidaceae) species from Brazil, with a revised world key
Authors: FEUERSTEIN Shirley Cunha , CUNHA-DIAS Iane Paula Rego , APTROOT André , ELIASARO Sionara , CÁCERES Marcela Eugenia da Silva 
Published: October 2014

AbstractThree new corticolous Diorygma species are described from Brazil. Diorygma incantatum has transversely 29–31-septate, filiform ascospores 105–108×6 µm, and produces an unidentified substance with Rf 44 in solvent C. Diorygma pauciseptatum produces norstictic and connorstictic acids and has transversely 7–9-septate, I+ blue-violet, large ascospores 28–32×7 µm, surrounded by a gelatinous sheath c. 2 µm wide that is often somewhat expanded at one end. Diorygma tocantinense contains protocetraric acid and has muriform, broadly fusiform ascospores with rounded ends, 24–40×10–15 µm, surrounded by an gelatinous sheath up to c. 5 µm wide that is somewhat expanded at central parts of the ascospore. A revised world key is given to all currently known species of Diorygma.
Spatio-temporal modelling of disease incidence with missing covariate values
Authors: HOLLAND R. C. , JONES G. , BENSCHOP J. 
Published: October 2014

SUMMARYThe search for an association between disease incidence and possible risk factors using surveillance data needs to account for possible spatial and temporal correlations in underlying risk. This can be especially difficult if there are missing values for some important covariates. We present a case study to show how this problem can be overcome in a Bayesian analysis framework by adding to the usual spatio-temporal model a component for modelling the missing data.
Assessment of inter-atrial, inter-ventricular, and atrio-ventricular interactions in tetralogy of Fallot patients after surgical correction. Insights from two-dimensional speckle tracking and three-dimensional echocardiography
Authors: Abd El Rahman Mohamed , Raedle-Hurst Tanja , Rentzsch Axel , Schäfers Hans-Joachim , Abdul-Khaliq Hashim 
Published: October 2014

AbstractBackground: We aimed to assess biatrial size and function, interactions on atrial and ventricular levels, and atrio-ventricular coupling in patients after tetralogy of Fallot repair. Methods: A total of 34 patients with a mean age of 20.9±9 years, and 35 healthy controls, underwent two-dimensional speckle tracking echocardiography for ventricular and atrial strain measurements and real-time three-dimensional echocardiography to assess ventricular and atrial volumes. Results: When compared with controls, tetralogy of Fallot patients had significantly reduced right atrial peak atrial longitudinal strain (p<0.01), right atrial peak atrial contraction strain (p<0.01), right atrial ejection fraction (p<0.01), left atrial peak atrial longitudinal strain (p<0.01), left atrial peak atrial contraction strain (p<0.05), and left atrial ejection fraction (p<0.01). In the tetralogy of Fallot group, left ventricular ejection fraction was negatively related to the right ventricular end-systolic volume normalised to body surface area (r=−0.62, p<0.01). An association was found in patients between the right atrial peak longitudinal strain and mean right ventricular strain (r=0.64, p<0.01). In patients, the left atrial peak longitudinal strain correlated negatively with right atrial end-diastolic volume normalised to body surface area (r=−0.67, p<0.01), whereas the left atrial ejection fraction correlated weakly with left ventricular ejection fraction (r=0.41, p<0.05). Conclusions: In asymptomatic tetralogy of Fallot patients, biatrial dysfunction exists and can be quantified via two-dimensional speckle tracking echocardiography as well as real-time three-dimensional echocardiography. Different forms of interactions on atrial and ventricular levels are evident among such cohorts.
Differential and selective morpho-syntactic impairment in Spanish-Basque bilingual aphasia
Authors: MUNARRIZ AMAIA , EZEIZABARRENA MARIA-JOSÉ , GUTIERREZ-MANGADO M. JUNCAL 
Published: October 2014

This paper reports on the comprehension of movement-derived structures by a Spanish-Basque bilingual with chronic Broca's aphasia. The study reveals adifferential impairmentwhich affects mostly Basque and aselective impairmentin this language that affects only object questions and subject relatives. The impairment pattern observed is discussed in light of the predictions made by different representational and processing accounts for (monolingual as well as bilingual) Spanish and Basque agrammatism.The asymmetry observed between the two languages suggests that the patient resorts to language-specific morpho-syntactic cues, which cannot be transferred from one language to the other because of the typological distance between Spanish and Basque. The data confirm results from previous studies showing that (major) typological distance hinders cross-language effects from arising in bilingual aphasia.
CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progression
Authors: Lin L , Han M-M , Wang F , Xu L-L , Yu H-X , Yang P-Y 
Published: October 2014

AbstractThe CXCL12/CXCR4 axis has been posited widely to have significant roles in many primary tumors and metastases. It is known that CXCR7 can also be engaged by CXCL12, but the exact function of CXCR7 is controversial. This prompted us to investigate the expression, specific function and signal transduction of CXCR7 in hepatocellular carcinoma (HCC). In this study, CXCR7 and CXCR4 were differentially expressed in nine cell lines of HCC, and that elevated expression of both CXCR7 and CXCL4 were correlated with highly metastatic ability of HCC cells. Moreover, CXCR7 expression was significantly upregulated in metastatic HCC samples compared with the non-metastatic ones by staining of high-density tissue microarrays constructed from a cohort of 48 human HCC specimens. CXCR7 overexpression enhanced cell growth and invasiveness in vitro, and tumorigenicity and lung metastasis in vivo. By contrast, CXCR7 stable knockdown markedly reduced these malignant behaviors. In addition, it was observed that alterations in CXCR7 expression were positively correlated with the phosphorylation levels of mitogen-activated protein kinase (MAPK) pathway proteins. Targeting extracellular regulated kinase pathway by using U0126 inhibitor or using CCX771, a selective CXCR7 antagonist, drastically reduced CXCR7-mediated cell proliferation. Importantly, by using human biotin-based antibody arrays, several differentially expressed proteins were identified in CXCR7-overexpression and depletion groups. Comparative analysis indicated that upstream regulators including TP53 and IL-6 were involved in CXCR7 signal transduction. CXCR7 expression was further proved to regulate expression of vascular endothelial growth factor A and galectin-3, which may contribute to tumor angiogenesis and invasiveness. Consequently, elevated expression of CXCR7 contributes to HCC growth and invasiveness via activation of MAPK and angiogenesis signaling pathways. Targeting CXCR7 may prevent metastasis and provide a potential therapeutic strategy for HCC.
Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation
Authors: Huang H , Shah K , Bradbury N A , Li C , White C 
Published: October 2014

AbstractMcl-1 is an antiapoptotic member of the Bcl-2 family frequently upregulated in non-small cell lung carcinoma (NSCLC). We now report the physiological significance of an interaction between Mcl-1 and the mitochondrial outer membrane-localized voltage-dependent anion channel (VDAC) in NSCLC cell lines. Mcl-1 bound with high affinity to VDAC1 and 3 isoforms but only very weakly to VDAC2 and binding was disrupted by peptides based on the VDAC1 sequence. In A549 cells, reducing Mcl-1 expression levels or application of VDAC-based peptides limited Ca2+ uptake into the mitochondrial matrix, the consequence of which was to inhibit reactive oxygen species (ROS) generation. In A549, H1299 and H460 cells, both Mcl-1 knockdown and VDAC-based peptides attenuated cell migration without affecting cell proliferation. Migration was rescued in Mcl-1 knockdown cells by experimentally restoring ROS levels, consistent with a model in which ROS production drives increased migration. These data suggest that an interaction between Mcl-1 and VDAC promotes lung cancer cell migration by a mechanism that involves Ca2+-dependent ROS production.
Dynamic involvement of ATG5 in cellular stress responses
Authors: Lin H H , Lin S-M , Chung Y , Vonderfecht S , Camden J M , Flodby P , Borok Z , Limesand K H , Mizushima N , Ann D K 
Published: October 2014

AbstractAutophagy maintains cell and tissue homeostasis through catabolic degradation. To better delineate the in vivo function for autophagy in adaptive responses to tissue injury, we examined the impact of compromised autophagy in mouse submandibular glands (SMGs) subjected to main excretory duct ligation. Blocking outflow from exocrine glands causes glandular atrophy by increased ductal pressure. Atg5f/−;Aqp5-Cre mice with salivary acinar-specific knockout (KO) of autophagy essential gene Atg5 were generated. While duct ligation induced autophagy and the expression of inflammatory mediators, SMGs in Atg5f/−;Aqp5-Cre mice, before ligation, already expressed higher levels of proinflammatory cytokine and Cdkn1a/p21 messages. Extended ligation period resulted in the caspase-3 activation and acinar cell death, which was delayed by Atg5 knockout. Moreover, expression of a set of senescence-associated secretory phenotype (SASP) factors was elevated in the post-ligated glands. Dysregulation of cell-cycle inhibitor CDKN1A/p21 and activation of senescence-associated β-galactosidase were detected in the stressed SMG duct cells. These senescence markers peaked at day 3 after ligation and partially resolved by day 7 in post-ligated SMGs of wild-type (WT) mice, but not in KO mice. The role of autophagy-related 5 (ATG5)-dependent autophagy in regulating the tempo, duration and magnitude of cellular stress responses in vivo was corroborated by in vitro studies using MEFs lacking ATG5 or autophagy-related 7 (ATG7) and autophagy inhibitors. Collectively, our results highlight the role of ATG5 in the dynamic regulation of ligation-induced cellular senescence and apoptosis, and suggest the involvement of autophagy resolution in salivary repair.
MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy
Authors: Li X , Du N , Zhang Q , Li J , Chen X , Liu X , Hu Y , Qin W , Shen N , Xu C , Fang Z , Wei Y , Wang R , Du Z , Zhang Y , Lu Y 
Published: October 2014

AbstractDiabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result in cardiac hypertrophy and subsequent heart failure, associated with pyroptosis, the pro-inflammatory programmed cell death. MicroRNAs (miRNAs), small endogenous non-coding RNAs, have been shown to be involved in diabetic cardiomyopathy. However, whether miRNAs regulate pyroptosis in diabetic cardiomyopathy remains unknown. Our study revealed that mir-30d expression was substantially increased in streptozotocin (STZ)-induced diabetic rats and in high-glucose-treated cardiomyocytes as well. Upregulation of mir-30d promoted cardiomyocyte pyroptosis in diabetic cardiomyopathy; conversely, knockdown of mir-30d attenuated it. In an effort to understand the signaling mechanisms underlying the pro-pyroptotic property of mir-30d, we found that forced expression of mir-30d upregulated caspase-1 and pro-inflammatory cytokines IL-1β and IL-18. Moreover, mir-30d directly repressed foxo3a expression and its downstream protein, apoptosis repressor with caspase recruitment domain (ARC). Furthermore, silencing ARC by siRNA mimicked the action of mir-30d: upregulating caspase-1 and inducing pyroptosis. These findings promoted us to propose a new signaling pathway leading to cardiomyocyte pyroptosis under hyperglycemic conditions: mir-30d↑→foxo3a↓→ ARC↓→caspase-1↑→IL-1β, IL-18↑→pyroptosis↑. Therefore, mir-30d may be a promising therapeutic target for the management of diabetic cardiomyopathy.