bluuebunny/crossref_metadata_2025_split huggingface dataset:
COLHEITA E GERMINAÇÃO DE SEMENTES DE IPÊ (Tabebuia chrysotricha)
Authors: MARTINELLI-SENEME Adriana , HOFFMAN Susane , POSSAMAI Edilberto 
Published: January 2015

O objetivo deste trabalho foi identificar o momento de colheita e o substrato mais favorável à germinação das sementes de ipê (Tabebuia chrysotricha (Mart. ex DC.) Standl.) As síliquas de ipê foram colhidas diretamente da copa em 12 árvores matrizes em outubro de 2004 e, em seguida, foram separadas em grupos, segundo as características físicas que identificaram os estágios de colheita: 1) síliqua maior que 20 cm de comprimento e fechada; 2) síliqua menor que 20 cm de comprimento e fechada; 3) síliqua em início de abertura e 4) síliqua aberta e em início de dispersão. Para caracterização dos estágios, mensurou-se a espessura, a largura e o comprimento das síliquas, exceto para aquelas do estágio de colheita 4 que já encontravam-se abertas impossibilitando o procedimento. Determinou-se o teor de água. O teste de germinação foi conduzido sob temperatura constante de 25 °C em três substratos: papel filtro, areia e vermiculita e as avaliações realizadas aos sete e 14 dias após a instalação do teste. A análise estatística foi realizada em esquema fatorial 4 x 3 (quatro estágios de colheita e três tipos de substrato), em delineamento inteiramente casualizado, com quatro repetições de 50 sementes para cada tratamento. As médias comparadas pelo teste de Tukey (P>0,05). De acordo com os resultados, verificou-se que o substrato vermiculita proporcionou germinação mais rápida do que o papel, em qualquer estágio de colheita das sementes, e que as sementes provenientes de síliquas fechadas, com teor de água entre 63,1 e 64,3%, apresentaram maiores valores de germinação, independente do substrato utilizado.
Premières identifications d’un profil traumatique chez des patients hospitalisés en psychiatrie en Martinique
Authors: Evans M. , Vacher E. , Lamy S. , Seridi H. , Jan M. , Debien C. , Sigward J.-M. , Jehel L. 
Published: January 2015

La population hospitalisée en psychiatrie apparaît davantage exposée à des événements traumatiques que la population française en général, avec plus particulièrement des agressions à caractère sexuel. Notre objectif principal est de décrire la population hospitalisée en psychiatrie et en particulier l’histoire traumatique des patients, les comorbidités associées (psychiatriques et addictologiques) ainsi que le niveau socioéconomique. Cette étude descriptive, transversale et rétrospective a été réalisée au Centre de crise du Centre Hospitalo-Universitaire de Martinique de février à juillet 2013. Un questionnaire socioéconomique, le Mini International Neuropsychiatric Interview 5.0, le Trauma History Questionnaire et le questionnaire Impact Events Scale-Revised (IES-R) ont été réalisés de façon aléatoire auprès de 49 des 143 patients admis sur cette période (soit 34,3 %). Dans notre échantillon, une moyenne de 6,5 types différents d’événements traumatiques a été établie (écart-type = 4,2) : 38,8 % des patients rapportent un traumatisme à la suite d’une catastrophe naturelle, et 38,8 % déclarent au moins une agression sexuelle. Parmi les 25 patients souffrant de syndrome de stress post-traumatique, 66,7 % ont subi une agression sexuelle dans l’enfance, avant l’âge de 10 ans (P = 0,01), et dans l’adolescence, entre 10 et 18 ans (P = 0,01). Ces résultats soulignent l’importance d’interroger systématiquement le profil traumatique, c’est-à-dire l’association entre les événements traumatiques et leur retentissement clinique.
Water‐Based Blend Nanoparticles of P3HT and PCBM for the Application in Organic Solar Cells
Authors: Ghazy Omayma A. 
Published: January 2015

ABSTRACTIn this work, blend nanoparticles of poly(3‐hexylthiophene) (P3HT) and phenyl‐C61‐butyric acid methyl ester (PCBM) were prepared with different composition ratios, namely 50:50, 60:40, and 70:30. Larger particle size is found for the blend nanoparticles with higher P3HT content, as measured by dynamic light scattering and transmission electron microscopy. The blending of nanoparticles did not affect the optical properties of the two materials as indicated by the UV–vis absorption spectra. The photoluminescence spectra of the blend nanoparticles reveal an efficient charge separation reflected by the quenching of the P3HT emission band by the PCBM. The quenching efficiency increases as the content of the PCBM increases. Good layer morphologies were obtained from casting the blend nanoparticles. The layer morphology was further improved by thermal annealing as indicated from the atomic force microscopy results. The water‐based dispersions offer a promising straightforward strategy toward the large‐scale fabrication of organic solar cells.
Facial asymmetry and genetic ancestry inLatinAmerican admixed populations
Authors: Quinto‐Sánchez Mirsha , Adhikari Kaustubh , Acuña‐Alonzo Victor , Cintas Celia , Silva de Cerqueira Caio Cesar , Ramallo Virginia , Castillo Lucia , Farrera Arodi , Jaramillo Claudia , Arias Williams , Fuentes Macarena , Everardo Paola , de Avila Francisco , Gomez‐Valdés Jorge , Hünemeier Tábita , Gibbon Shara , Gallo Carla , Poletti Giovanni , Rosique Javier , Bortolini Maria Cátira , Canizales‐Quinteros Samuel , Rothhammer Francisco , Bedoya Gabriel , Ruiz‐Linares Andres , González‐José Rolando 
Published: January 2015

ABSTRACTFluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin‐American admixed populations. To do so, three‐dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome‐wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry‐admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise. Am J Phys Anthropol 157:58–70, 2015. © 2015 Wiley Periodicals, Inc.
Organische Synthese: Vormarsch der Maschinen
Authors: Ley Steven V. , Fitzpatrick Daniel E. , Ingham Richard. J. , Myers Rebecca M. 
Published: January 2015

AbstractDie organische Synthese ist im Wandel begriffen: Da Forschungsetats zunehmend gekürzt werden und der Einfluss chemischer Verfahren auf die Umwelt genau geprüft wird, wird immer deutlicher, dass der effiziente Einsatz von Personal im Labor mindestens so bedeutsam ist wie die Materialverwendung. Neue Techniken und Maschinen verändern unsere Arbeitsweise, und indem die zuvor genannten Punkte — Personal und Material – erfasst werden, ermöglichen sie es Chemikern in Forschungslaboratorien, einen eher ganzheitlichen Ansatz für ihre Tätigkeit zu finden. Moderne Entwicklungen auf diesem Gebiet fördern multidisziplinäres Vorgehen mit dem Ergebnis effizienterer Arbeit. Dieser Aufsatz behandelt die Konzepte, Verfahren und Methoden, die weitreichende Implikationen für die Chemie insgesamt haben. Thematisch ist der Aufsatz nach unterschiedlichen Anwendungsmöglichkeiten gegliedert, und neuere Anwendungen in innovativen Forschungslabors werden beschrieben.
Biofabrication of Cell‐Loaded 3D Spider Silk Constructs
Authors: Schacht Kristin , Jüngst Tomasz , Schweinlin Matthias , Ewald Andrea , Groll Jürgen , Scheibel Thomas 
Published: January 2015

AbstractBiofabrication is an emerging and rapidly expanding field of research in which additive manufacturing techniques in combination with cell printing are exploited to generate hierarchical tissue‐like structures. Materials that combine printability with cytocompatibility, so called bioinks, are currently the biggest bottleneck. Since recombinant spider silk proteins are non‐immunogenic, cytocompatible, and exhibit physical crosslinking, their potential as a new bioink system was evaluated. Cell‐loaded spider silk constructs can be printed by robotic dispensing without the need for crosslinking additives or thickeners for mechanical stabilization. Cells are able to adhere and proliferate with good viability over at least one week in such spider silk scaffolds. Introduction of a cell‐binding motif to the spider silk protein further enables fine‐tuned control over cell–material interactions. Spider silk hydrogels are thus a highly attractive novel bioink for biofabrication.
Phosphonic acid‐containing polysulfones as anticorrosive layers
Authors: Chauveau Edouard , Marestin Catherine , Mercier Régis , Brunaux Alexis , Martin Vincent , Nogueira Ricardo P. , Percheron Aurélien , Roche Virginie , Waton Hugues 
Published: January 2015

ABSTRACTAs a part of research work to elaborate polymeric materials for metal corrosion protection, we have developed a new family of phosphonic acid‐containing polymers. The synthesis and the characterization of polysulfones bearing alkyl phosphonate ester side groups are first described. These polymers are synthesized by direct polycondensation of a phosphonate ester‐containing bisphenol by aromatic nucleophilic substitution. The physicochemical properties of the resulting polymers are described. Acidic hydrolysis of phosphonate esters results in the formation of phosphonic acid groups. A series of phosphonic acid‐containing polysulfones is therefore obtained and characterized. A preliminary evaluation of the anticorrosive properties of these polymers is described. In 0.25M Na2SO4 solution, the corrosion rate of a polymer‐coated mild steel sample is much lower than of the free metal substrate. These results suggest that phosphonic acid‐containing polysulfones might be interesting as anticorrosive coatings. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41890.
Epoxide‐terminated hyperbranched polyether sulphone as triple enhancement modifier for DGEBA
Authors: Miao Xuepei , Meng Yan , Li Xiaoyu 
Published: January 2015

ABSTRACTEpoxide‐terminated hyperbranched polyether sulphones (EHBPESs) with different backbone structures were synthesized and used as tougheners for diglycidyl ether of bisphenol‐A (DGEBA) curing system, which result in nonphase‐separated cured networks. Effects of backbone structure (at comparable degree of polymerization) and loading contents on the mechanical and thermal properties of cured hybrids were investigated. The hybrid containing EHBPES3, which has the most flexible backbone, shows the best mechanical performance and highest glass transition temperature (Tg). Compared with unmodified system, the impact strength, tensile strength, elongation at break of the hybrid containing 5% EHBPES3 increased by 69.8%, 9.4%, and 60.2%, respectively. The balanced improvements were attributed to the increased crosslink density and fractional free volume as well as the unique inhomogeneous network structure because of incorporation of hyperbranched modifiers with proper structure and loading contents. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41910.
The Future of Social Policy—Changing the Paradigm
Authors: Piachaud David 
Published: January 2015

AbstractThe future of the social state is, throughout the world, uncertain, but, as Piketty argues, it is of the utmost importance. The dominant paradigm for thinking about social policy both in terms of government action and academic analysis has been the social service model, as exemplified in the work of Richard Titmuss. In the West, there has been a growing crisis in social policy. Demand for social services has increased for demographic, economic, technological and political reasons; supply has been constrained for economic and political reasons. There is a growing realisation that social services are only one, often small, factor in determining social outcomes. Yet the social service model focuses largely on inputs. It is argued, with examples from across the life cycle, that the paradigm for social policy needs to change from focusing on inputs to focusing on the intended outcomes or social goals.
Hofmeister Phenomena in Bioelectrochemistry: The Supporting Electrolyte Affects the Response of Glucose Electrodes
Authors: Carucci Cristina , Haltenort Philipp , Salazar Marcela , Salis Andrea , Magner Edmond 
Published: January 2015

AbstractThe faradaic response of ferrocene–methanol when used as a mediator for the catalytic oxidation of glucose by glucose oxidase was examined in a range of electrolytes. The response was modulated by the nature of the salt used. A two‐fold difference was observed with the sodium salts of fluoride and thiocyanate, with a 24 % difference between NaCl and KCl. The changes in the response can be explained by the Hofmeister effect, with specific ion effects arising between the mediator and the co‐substrate binding pocket of the enzyme. Such differences can significantly affect the response of electrochemically mediated glucose biosensors and biofuel cells and emphasise the importance of carefully considering the solution conditions when evaluating the properties of glucose oxidase based biosensors and biofuel cells.
Loading of a Coordination Polymer Nanobelt on a Functional Carbon Fiber: A Feasible Strategy for Visible‐Light‐Active and Highly Efficient Coordination‐Polymer‐Based Photocatalysts
Authors: Xu Xin‐Xin , Yang Hong‐Yu , Li Zhen‐Yu , Liu Xiao‐Xia , Wang Xiu‐Li 
Published: January 2015

AbstractTo improve the photocatalytic properties of coordination polymers under irradiation in the visible‐light region, coordination polymer nanobelts (CPNB) were loaded on functional carbon fiber (FCF) through the use of a simple colloidal blending process. The resulting coordination polymer nanobelt loaded functional carbon fiber composite material (CPNB/FCF) exhibited dramatically improved photocatalytic activity for the degradation of rhodamine B (RhB) under visible‐light irradiation. Optical and electrochemical methods illustrated the enhanced photocatalytic activity of CPNB/FCF originated from high separation efficiency of photogenerated electrons and holes on the interface of CPNB and FCF, which was produced by the synergy effect between them. In the composite material, the role of FCF could be described as photosensitizer and good electron transporter. For FCF, the number of functional groups on its surface has a significant influence on the photocatalytic performance of the resulting CPNB/FCF composite material, and an ideal FCF carrier was obtained as a highly efficient CPNB/FCF photocatalyst. CPNB/FCF showed outstanding stability during the degradation of rhodamine B (RhB); thus, the material is suitable for use as a photocatalyst in the treatment of organic dyes in water.
pH‐Regulated Selectivity in Supramolecular Polymerizations: Switching between Co‐ and Homopolymers
Authors: Frisch Hendrik , Nie Yan , Raunser Stefan , Besenius Pol 
Published: January 2015

AbstractA strategy is presented to regulate the selectivity in aqueous supramolecular polymerizations by changes in pH. In neutral buffered conditions, oppositely charged phenylalanine‐based dendritic peptide amphiphiles self‐assemble into (AB)n alternating copolymers of low polydispersity when mixed in a 1:1 comonomer feed ratio. Via pH switch of the glutamic acid and lysine side chains, attractive Coulomb interactions in the coassembled materials are screened and selective polymerization occurs to form (A)n homopolymers of the acidic comonomer at low pH and (B)n homopolymers of the basic comonomer at high pH, while the complementary comonomer is released during the transition. Reversible switching is demonstrated between these three different polymeric states, which were characterized by CD and fluorescence spectroscopy, using a peptide based minimalistic fluorophore/quencher pair, and transmission electron microscopy.
A prospective nonrandomized phase I/II study of carbon ion radiotherapy in a favorable subset of locally advanced non–small cell lung cancer (NSCLC)
Authors: Takahashi Wataru , Nakajima Mio , Yamamoto Naoyoshi , Yamashita Hideomi , Nakagawa Keiichi , Miyamoto Tadaaki , Tsuji Hiroshi , Kamada Tadashi , Fujisawa Takehiko 
Published: January 2015

BACKGROUNDAlthough concurrent chemoradiotherapy (CCRT) has become the standard approach for unresectable locally advanced non–small cell lung cancer (LA‐NSCLC), most patients are not candidates for this treatment because of comorbidities. We evaluated the safety and efficacy of carbon ion radiotherapy (CIRT) in LA‐NSCLC patients.METHODSPatients with stage IIA to IIIA (UICC 7th edition) LA‐NSCLC were enrolled in a sequential phase I/II trial. For a phase I dose escalation study, the total prescribed dose was increased by 4 Gray equivalents (GyE) in 2 steps, from 68 to 72 GyE and then to 76 GyE, using 16 fractions over 4 weeks. After determining the recommended dose, the phase II trial was started in an expanded cohort.RESULTSOf the 36 patients treated in phase I, 2 grade 3 adverse events (radiation pneumonitis and tracheoesophageal fistula) were observed in the 76 GyE group. Accordingly, for phase II, the next consecutive 26 patients were treated with 72 GyE, with no grade 3 to 5 toxicities resulting. A total of 62 eligible patients were recruited. The majority of patients (49 of 62) were N0 or N1 patients, and the rest (13 of 62) were single‐station N2 patients. The median follow‐up period was 25.2 months. The 2‐year local control rate (LCR) and overall survival (OS) for the entire cohort were 93.1% and 51.9%, respectively. In particular, patients with cT3‐4N0 had an excellent prognosis; the 2‐year OS and LCR were 69.3% and 100%, respectively.CONCLUSIONSShort‐course CIRT monotherapy shows promise as an effective nonsurgical treatment for inoperable LA‐NSCLC. Cancer 2015;121:1321–1327. © 2014 American Cancer Society.
Clinical value of ERG, TFF3, and SPINK1 for molecular subtyping of prostate cancer
Authors: Terry Stéphane , Nicolaiew Nathalie , Basset Victor , Semprez Fannie , Soyeux Pascale , Maillé Pascale , Vacherot Francis , Ploussard Guillaume , Londoño‐Vallejo Arturo , de la Taille Alexandre , Allory Yves 
Published: January 2015

BACKGROUNDIn view of the marked molecular heterogeneity of prostate cancer (PCa), clinical and pathologic parameters alone may be unreliable for predicting disease outcomes after surgical intervention. The development of biomarkers may be helpful to estimate tumor heterogeneity and stratify patients in terms of their risk of progression. Levels of v‐ets avian erythroblastosis virus E26 oncogene homolog (ERG), trefoil factor 3 (TFF3), and serine peptidase inhibitor, Kazal type 1 (SPINK1) are commonly elevated in PCa, but it is unclear whether the evaluation of these 3 markers can help to discriminate patients who will have different clinical outcomes. The authors investigated whether assessment of ERG, TFF3, and SPINK1 expression could help to define clinically relevant, distinct subsets of patients with PCa.METHODSThe cohort consisted of 279 men with PCa who underwent radical prostatectomy at Henri Mondor Hospital. Expression levels of ERG, TFF3, and SPINK1 were evaluated immunohistochemically in the prostatectomy specimens. Potential associations of ERG, TFF3, and SPINK1 with age, prostate‐specific antigen (PSA), tumor stage, Gleason score, and biochemical recurrence, defined by PSA failure, were investigated.RESULTSAlthough prognostic significance was not observed for ERG or TFF3, an exclusive pattern of expression was demonstrated for TFF3 and ERG. SPINK1 expression was observed exclusively in a subgroup of cancers that expressed TFF3 (41 of 175 tumors). Moreover, SPINK1 positivity was identified as predictive of biochemical recurrence in univariate (P = .0009) and multivariate (P = .0003) analyses.CONCLUSIONSThe current results suggest that ERG and TFF3 characterize 2 distinct subsets of PCa, with a more aggressive subgroup of TFF3‐expressing tumors that express SPINK1. Together, these findings support a rationale of screening for these biomarkers for prognostic purposes and molecular subtyping of the disease. Cancer 2015;121:1422–1430. © 2015 American Cancer Society.
Final analysis of the efficacy and safety of omacetaxine mepesuccinate in patients with chronic‐ or accelerated‐phase chronic myeloid leukemia: Results with 24 months of follow‐up
Authors: Cortes Jorge E. , Kantarjian Hagop M. , Rea Delphine , Wetzler Meir , Lipton Jeffrey H. , Akard Luke , Khoury H. Jean , Michallet Mauricette , Guerci‐Bresler Agnès , Chuah Charles , Hellmann Andrzej , Digumarti Raghunadharao , Parikh Purvish M. , Legros Laurence , Warzocha Krzysztof , Baccarani Michele , Li Elizabeth , Munteanu Mihaela , Nicolini Franck E. 
Published: January 2015

BACKGROUNDOmacetaxine, a protein synthesis inhibitor, is indicated in the United States for the treatment of patients with chronic‐phase (CP) or accelerated‐phase (AP) chronic myeloid leukemia (CML) with resistance and/or intolerance to 2 or more tyrosine kinase inhibitors.METHODSThe final analysis, with 24 months of follow‐up, included additional efficacy and safety analyses to assess the benefit of long‐term omacetaxine administration (1.25 mg/m2 twice daily for 14 days every 28 days followed by 7 days every 28 days) in CP‐CML and AP‐CML patients receiving >3 cycles.RESULTSEighteen percent of CP‐CML patients achieved a major cytogenetic response (MCyR) with a median duration of 12.5 months (95% confidence interval [CI], 3.5 months to not reached [NR]); responses were maintained for ≥12 months in 3 of 14 responders, and the median overall survival (OS) was 40.3 months (95% CI, 23.8 months to NR). Among patients with AP‐CML, 14% achieved or maintained a major hematologic response for a median of 4.7 months (95% CI, 3.6 months to NR); MCyR was not achieved, and the median OS was 14.3 months (95% CI, 6.7‐18.7 months). In patients with CP‐CML and patients with AP‐CML who received >3 cycles of treatment (n = 50 and n = 14, respectively), the median OS was 49.3 months (95% CI, 23.8 months to NR) and 24.6 months (95% CI, 12‐37.2 months), respectively. Grade 3 or higher hematologic toxicities were the major side effects (79% and 73% for CP‐CML and AP‐CML, respectively), with discontinuation due to toxicity in 10% of CP patients and in 5% of AP patients.CONCLUSIONSThese results suggest that the long‐term administration of omacetaxine is feasible with dose adjustments to manage toxicities and that omacetaxine provides a durable benefit for some patients. Cancer 2015;121:1637–1644. © 2015 American Cancer Society.