bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of underlying laryngeal pathology in patients initially diagnosed with laryngopharyngeal reflux
Authors: Rafii Benjamin , Taliercio Salvatore , Achlatis Stratos , Ruiz Ryan , Amin Milan R. , Branski Ryan C. 
Published: October 2013

Objectives/HypothesisTo characterize the videoendoscopic laryngeal findings in patients with a prior established diagnosis of laryngopharyngeal reflux disease (LPR) as the sole etiology for their chief complaint of hoarseness. We hypothesized that many, if not all, of these patients would present with discrete laryngeal pathology, divergent from LPR.Study DesignProspective, nonintervention.MethodsPatients presenting to a tertiary laryngology practice with an established diagnosis of LPR as the sole etiology of their hoarseness were included. All subjects completed the Voice Handicap Index and Reflux Symptom Index, in addition to a questionnaire regarding their reflux diagnosis and prior treatment. Laryngoscopic examinations were reviewed by the laryngologist caring for the patients. Reliability of findings was assessed by interpretation of videoendoscopic findings by three outside laryngologists not involved in the care of the patients.ResultsLaryngeal pathology distinct from LPR was identified in all 21 patients felt to be causative of the chief complaint of dysphonia. Specifically, the most common findings were benign mucosal lesions and vocal fold paresis (29% each), followed by muscle tension dysphonia (14%). Two patients were found to have vocal fold leukoplakia, of which one was confirmed to be a microinvasive carcinoma upon removal.ConclusionLPR may be overdiagnosed; other etiologies must be considered for patients with hoarseness who fail empiric LPR treatment.Level of Evidence4. Laryngoscope, 124:1420–1424, 2014
A novel coumarin‐quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death
Authors: Bana Emilie , Sibille Estelle , Valente Sergio , Cerella Claudia , Chaimbault Patrick , Kirsch Gilbert , Dicato Mario , Diederich Marc , Bagrel Denyse 
Published: October 2013

AbstractCell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high‐grade tumors and poor prognosis. Thus, targeting CDC25 by compounds, able to inhibit their activity, appears a good therapeutic approach. Here, we describe the synthesis of a new inhibitor (SV37) whose structure is based on both coumarin and quinone moieties. An analytical in vitro approach shows that this compound efficiently inhibits all three purified human CDC25 isoforms (IC50 1–9 µM) in a mixed‐type mode. Moreover, SV37 inhibits growth of breast cancer cell lines. In MDA‐MB‐231 cells, reactive oxygen species generation is followed by pCDK accumulation, a mark of CDC25 dysfunction. Eventually, SV37 treatment leads to activation of apoptosis and DNA cleavage, underlining the potential of this new type of coumarin–quinone structure. © 2013 Wiley Periodicals, Inc.
Application of EMBM to Structure‐Based Design of Warheads for Protease Inhibitors
Authors: Traube Tamar , Shokhen Michael , Albeck Amnon 
Published: October 2013

AbstractMost CADD tools handle non‐covalent enzyme inhibitors, despite the growing interest of the pharma industry in covalent inhibitors. We have recently introduced an enzyme mechanism‐based method, EMBM, as a computational tool for binding trend analysis and prediction of chemical sites (CS) of reversible covalent enzyme inhibitors. In the current study we demonstrate the utility of EMBM to structure‐based applications. In this mode, the energy of the enzyme‐inhibitor covalent bond is accounted for by the W1 and W2 covalent descriptors we have developed, whereas the non‐covalent interactions between the inhibitor CS and the enzyme active site can be estimated directly on the 3D structure of the enzyme‐inhibitor complex.
Integrating Computational Modeling and Experimental Assay to Discover New Potent ACE‐Inhibitory Peptides
Authors: Ren Yanrong , Wang Qiang , Chen Shaocheng , Cao Haiyan 
Published: October 2013

AbstractHuman angiotensin‐I‐converting enzyme (ACE) is an important target of antihypertensive therapy, which possesses a bulky, hydrophobic pocket that is physicochemically compatible with a wide variety of peptide substrates and small‐molecule ligands. Rational design of potent ACE inhibitors has long been an attractive topic in the chemical, biological and medical communities. In the present study, an integrative protocol is described to optimize and modify peptides bound with ACE based on their complex three‐dimensional structures. The protocol combines a number of sophisticated computational methods including molecular dynamics (MD) simulation, quantitative structure‐activity relationship (QSAR), molecular mechanics/Poisson‐Boltzmann surface area (MM‐PB/SA) and quantum mechanics/molecular mechanics (QM/MM) to discover new potent ACE‐inhibitory peptides. With this strategy hundreds of potential peptides are generated virtually, from which several promising candidates are synthesized and assayed in vitro using a standard Fmoc‐protected amino acid solid phase synthesis and spectrophotometric method, respectively. Six peptides are found to have potency against ACE, four of which (LVY, VLKP, MLPVY and LKIPLY) show satisfactory inhibitory capability (pIC50=5.84, 5.27, 5.40 and 5.57, respectively). Subsequently, the complex structures of tripeptide LVY and hexapeptide LKIPLY with ACE are computationally modeled and their binding free energies are estimated as − 34.2 and − 57.8 kcal/mol, respectively, by using a rigorous QM/MM scheme. Intensive steric collisions are observed around the C‐terminus of peptide ligands in the bound state. Based upon the findings the C‐terminal residues of the two peptides are modified to small, hydrophobic amino acids Val and Ala, resulting in mutated peptides LVA and LKIPVA, respectively. Consequently, a significant improvement in ACE‐inhibitory activity is observed for the LKIPVA mutant (pIC50 increases from 5.57 to 6.07), whereas only a modest activity change was associated with the LVA mutant (pIC50 decreases from 5.84 to 5.80).
The impact of intranasal corticosteroids on lung function in children with allergic rhinitis
Authors: Kessel Aharon 
Published: October 2013

SummaryBackgroundSubjects with allergic rhinitis (AR) suffer from impaired lung function, especially decreased FEF25–75%. The purpose of this study was to examine lung function and the long‐term response to INCS in AR patients with impaired lung function, and to characterize the phenotype of these children.MethodsTwo hundred two children with AR underwent an allergy evaluation including a skin prick test and spirometry. Children with impaired lung function were treated with daily nasal corticosteroids spray (INCS) and antihistamine as needed.ResultsFifty‐three children out of 202 (26.3%) had impaired lung function: 34 of them (64.2%) had FEF25–75% values under 80% of predicted and normal FEV1 values, and 19 individuals (35.8%), had both FEF25–75% and FEV1 values below 80% of predicted. A positive correlation between FEV1 and FEF25–75% values (r = 0.369, P = 0.007) and a reverse correlation between duration of nasal symptoms and FEF25–75% values (r = −0.364, P = 0.012) were found. Post‐ronchodilation FEV1 levels increased from 81.9 ± 8.0 to 87.7 ± 10.4 (P < 0.0001). Thirty‐five of the 53 children complied with a continuous INCS treatment regimen over a period of 3–12 months, demonstrated increased FEF25–75% (84.4 ± 13.6 vs. 70.1 ± 7.1, P < 0.001) and FEV1 (92.3 ± 10.9 vs. 84.4 ± 7.8, P < 0.0001) after INCS treatment. However, FEF25–75% values were still significantly lower compared to the group of AR children with normal lung function (84.4 ± 13.6 vs. 95.7 ± 8.8, P < 0.0001).ConclusionsINCS improve FEF25–75% above 80% of predicted values in 2/3 of children with abnormal lung function. However, this improvement does not reach levels of AR children with normal lung function. Pediatr Pulmonol. 2014; 49:932–937. © 2013 Wiley Periodicals, Inc.
Post‐infection activities of fungicides againstCercospora arachidicolaof peanut (Arachis hypogaea)
Authors: Johnson Robert C. , Cantonwine Emily G. 
Published: October 2013

AbstractBACKGROUNDDespite strong indirect evidence of post‐infection activity by a selection of systemic fungicides against Cercospora arachidicola, the causal organism of early leaf spot of peanut, direct post‐infection activities in this pathosystem have yet to be reported in detail. This study was conducted to describe the activities of pyraclostrobin, penthiopyrad and prothioconazole on early leaf spot when each fungicide was applied after pathogen penetration began and throughout the incubation period.RESULTSMost C. arachidicola penetration events occurred between 3 and 5 days after inoculation (dai), and the mean incubation period was 11.8 dai. Post‐infection activities of the systemic fungicides were similar for all dependent variables measured. Systemic fungicides reduced lesion density compared with the non‐treated control when applied at 3, 5 and 7 dai, and disease severity was >60% less for leaves treated with a systemic fungicide at all application dates (3, 5, 7, 9, 11 and 13 dai).CONCLUSIONSPyraclostrobin, penthiopyrad and prothioconazole showed similar systemic mobility within peanut leaves and activities against C. arachidicola, and appear to completely arrest the development of the pathogen at least 2 days post penetration, and limit pathogen colonization even when applications occur after symptom onset. © 2013 Society of Chemical Industry
Insecticidal activities of Cunninghamia konishii Hayata against Formosan subterranean termite, Coptotermes formosanus (Isoptera: Rhinotermitidae)
Authors: Cheng Sen‐Sung , Lin Chun‐Ya , Chen Ying‐Ju , Chung Min‐Jay , Chang Shang‐Tzen 
Published: October 2013

AbstractBACKGROUNDFormosan subterranean termite, Coptotermes formosanus Shiraki (Isoptera: Rhinotermitidae), is a major urban pests in many countries throughout the world. In an attempt to find natural products that could be employed in the effective and environmentally friendly control of the termite, this study investigates, for the first time, the insecticidal activities of the wood and leaf essential oils and ethanolic extracts from Cunninghamia konishii Hayata against C. formosanus according to direct contact application.RESULTSWood and leaf essential oils and wood ethanolic extract showed the excellent antitermitic activities. Among the four fractions of wood ethanolic extract, the hexane‐soluble fraction showed the strongest antitermitic activities. In addition, β‐elemol and α‐cadinol showed excellent inhibitory action against C. formosanus.CONCLUSIONThe results clearly reveal that the wood and leaf essential oils and ethanolic extract from C. konishii, and their effective constituents, served as potential, eco‐friendly termite‐control agents. © 2013 Society of Chemical Industry
Influencing the conductance in biphenyl‐like molecular junctions with THz radiation
Authors: Hinreiner Matthias , Ryndyk Dmitry A. , Usvyat Denis , Merz Thomas , Schütz Martin , Richter Klaus 
Published: October 2013

We investigate the torsional vibrations in biphenyl‐like molecular junctions and transport properties in the presence of an external THz field. Ab initio calculations including external electric fields show that the torsional angle of a thiolated biphenyl junction exhibits virtually no response. However, if functional groups are added to the molecule, creating a dipole moment in each of the rings, an external field becomes more effective for changing . A model based on the dependence of the current for low bias voltages has been proposed for the biphenyl‐like molecular junctions in presence of an external THz field including 2,2‐bipyridine, 3,3‐bipyridine, and 2,2,4,4‐tetramethyl‐3,3‐bipyridine. The current through these molecules is shown to change if the THz frequency gets in resonance to the torsional vibration mode.Dithiolated bipyridine between gold leads in the presence of external THz radiation.
Improvement of operation temperature in GaAs/AlGaAs THz‐QCLs by utilizing high Al composition barrier
Authors: Lin Tsung‐Tse , Hirayama Hideki 
Published: October 2013

AbstractTerahertz quantum cascade lasers (THz‐QCLs) are compact THz laser source with narrow emission linewidth and high output power. Currently, a maximum operation temperature (Tmax) of 199.5 K is reported by using a state‐of‐the‐art longitudinal optical (LO) phonon depopulation scheme AlGaAs/GaAs structure. We propose an effective method to obtain higher operating temperature for AlGaAs/GaAs THz‐QCL by increasing LO‐phonon scattering energy by utilizing high Al composition AlGaAs barrier. We have successfully fabricated an LO phonon depopulation scheme AlGaAs/GaAs THz‐QCL with double metal waveguide, and obtained 3.7 THz lasing. We obtained the Tmax of 150 K. We observed an increase of Tmax by about 7 K by increasing the Al composition of AlGaAs barrier from 15% to 30%. The characteristic temperature (T0) was also improved from 44.7 K to 69.9 K by changing the Al composition of AlGaAs barriers. The increase of Al composition in AlGaAs‐based THz‐QCL was shown to be promising way for obtaining higher operating temperature of THz‐QCL. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
XPS analysis of the terminated‐bonding states at GaN surface after chemical and plasma treatments
Authors: Tsuji Yukihiro , Watanabe Tadashi , Nakamura Kenichi , Makabe Isao , Nakata Ken , Katsuyama Tsukuru , Teramoto Akinobu , Shirai Yasuyuki , Sugawa Shigetoshi , Ohmi Tadahiro 
Published: October 2013

AbstractIn order to improve reliability and yield of gallium nitride (GaN) devices, we have developed the formation of an ultra‐clean GaN surface and an interface of a passivation layer. The residue or termination materials on the GaN surface were analyzed after wet‐chemical and plasma treatments. In detail, the terminated‐bonding state of the GaN surface has been characterized by X‐ray photoelectron spectroscopy. After conventional diluted HF treatment, the GaN surface is still terminated by oxygen. (NH4)2Sx and SiH4 plasma treatments are required for the efficient removing of oxygen‐termination of the GaN surface. However, contaminants, except for nitrogen and gallium, are not removed from the GaN surface completely. For example, silicon is deposited on the GaN surface after the SiH4 plasma treatment, and atoms of sulfur are terminated on the GaN surface after the (NH4)2Sx treatment. However, we consider that their materials should be removed before the passivation film deposition. Therefore, the ultra‐clean interface of the passivation layer and the GaN surface were reported in this paper. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
In‐situ annealing effect of zinc‐blende MnAs thin films grown on InP substrates
Authors: Oomae Hiroto , Shimazaki Tsuneyuki , Toyota Hideyuki , Nakamura Shin‐ichi , Uchitomi Naotaka 
Published: October 2013

AbstractMnAs thin films were grown by molecular beam epitaxy on InP substrates. The samples were in‐situ annealed at different temperatures of 340 °C, 380 °C and 420 °C in an As4 atmosphere. High‐resolution X‐ray diffraction (XRD) measurements showed that zinc‐blende type (zb‐) and NiAs type (n‐) MnAs co‐exist. The XRD peak intensities of zb‐MnAs increased with annealing temperatures up to 380 °C. Also, the in‐plane XRD results showed that the intensities of zb‐MnAs (400) and (220) increased after annealing. On the other hand, the peak intensities of n‐MnAs decreased with temperature up to 380 °C. The possible transition between zinc‐blende and hexagonal MnAs is estimated to be a temperature of 380 °C. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Development of high‐quality titanium‐doped gallium ZnO transparent conductive films by RF magnetron sputtering techniques
Authors: Liu Wei‐Sheng , Wu Shen‐Yu , Tseng Ching‐Hsuan , Hung Chao‐Yu 
Published: October 2013

AbstractIn this paper, Ti‐doped GaZnO (GTZO) transparent conductive oxide (TCO) was deposited by radio‐frequency magnetron sputtering on glass substrates. X‐ray diffraction (XRD) of the crystalline quality of the resulting GTZO TCO showed a (002) peak with increased intensity for films deposited with annealing temperature from as‐grown to 450 °C. The low thin film resistivity of 1.57 × 10‐4 Ω‐cm, and average optical transmittance of 91% in the range between 350 and 800 nm, are also demonstrated to show the potential applications of this work. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Dislocation density dependence of stimulated emission characteristics in AlGaN/Al multiquantum wells
Authors: Matsubara Yuko , Yamada Tomoaki , Takeda Kenichiro , Iwaya Motoaki , Takeuchi Tetsuya , Kamiyama Satoshi , Akasaki Isamu , Amano Hiroshi 
Published: October 2013

AbstractWe investigated dislocation density dependence on stimulated emission characteristics of AlGaN/AlN multiquantum wells (MQWs: emission wavelength of approximately 285 nm) on AlN templates with various dislocation densities. We found that the stimulated emission characteristics of the deep UV MQWs were strongly dependent on the dislocation densities. A reduction of the dislocation densities is very important in order to realize good stimulated emission characteristics of deep UV MQWs. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Robotic revisional bariatric surgery: a comparative study with laparoscopic and open surgery
Authors: Buchs Nicolas C. , Pugin François , Azagury Dan E. , Huber Olivier , Chassot Gilles , Morel Philippe 
Published: October 2013

AbstractBackgroundRevisional bariatric procedures (RBP) can be technically challenging. While robotics might provide help for complex procedures, the study aim was to report our experience with robotic RBP.MethodsFrom March 2000 to June 2013, 60 consecutive RBP (11 robotic, 21 laparoscopic, 28 open) have been prospectively entered into a dedicated database and reviewed retrospectively. Outcomes have been compared between the three approaches.ResultsThe robotic group had fewer complications (0 vs. 14.3% for laparoscopy, vs. 10.7% for open; P > 0.05), but took longer than the other approaches (352 vs. 270 vs. 250 minutes respectively; P < 0.05). There were fewer conversions in the robotic group (0 vs. 14.3% for laparoscopy; P > 0.05), and a significantly shorter hospital stay (6 vs. 8 vs. 9 days, respectively).ConclusionsRobotic RBP is feasible and safe, but at the price of a longer operative time. The exact role of robotics remains yet to be defined for this indication in larger studies. Copyright © 2013 John Wiley & Sons, Ltd.
Discrete‐time H −  ∕ H ∞  sensor fault detection observer design for nonlinear systems with parameter uncertainty
Authors: Aouaouda S. , Chadli M. , Shi P. , Karimi H.R. 
Published: October 2013

SUMMARYThis work concerns robust sensor fault detection observer (SFDO) design for uncertain and disturbed discrete‐time Takagi–Sugeno (T–S) systems using H −  ∕ H ∞ criterion. The principle of the proposed approach is based on simultaneously minimizing the perturbation effect and maximizing the fault effect on the residual vector. Furthermore, by introducing slack decision matrices and taking advantage of the descriptor formulation, less conservative sufficient conditions are proposed leading to easier linear matrix inequalities (LMIs). Moreover, the proposed (SFDO) design conditions allow dealing with unmeasurable premise variables. Finally, a numerical example and a truck–trailer system model are proposed to illustrate the efficiency of the SFDO design methodology. Copyright © 2013 John Wiley & Sons, Ltd.
A distributed kernel summation framework for general‐dimension machine learning
Authors: Lee Dongryeol , Sao Piyush , Vuduc Richard , Gray Alexander G. 
Published: October 2013

AbstractKernel summations are a ubiquitous key computational bottleneck in many data analysis methods. In this paper, we attempt to marry, for the first time, the best relevant techniques in parallel computing, where kernel summations are in low dimensions, with the best general‐dimension algorithms from the machine learning literature. We provide the first distributed implementation of kernel summation framework that can utilize: (i) various types of deterministic and probabilistic approximations that may be suitable for low and high‐dimensional problems with a large number of data points; (ii) any multidimensional binary tree using both distributed memory and shared memory parallelism; and (iii) a dynamic load balancing scheme to adjust work imbalances during the computation. Our hybrid message passing interface (MPI)/OpenMP codebase has wide applicability in providing a general framework to accelerate the computation of many popular machine learning methods. Our experiments show scalability results for kernel density estimation on a synthetic ten‐dimensional dataset containing over one billion points and a subset of the Sloan Digital Sky Survey Data up to 6144 cores. © 2013 Wiley Periodicals, Inc. Statistical Analysis and Data Mining, 2013
Mechanisms to locate noncooperative transmitters in wireless networks based on residual signal strengths
Authors: Barthélémy Éric , Robert Jean‐Marc 
Published: October 2013

AbstractThis paper proposes new mechanisms for locating or tracking a noncooperative and immobile transmitter in wireless communication networks. They rely on a set of trusted cooperative receivers that are able to measure the residual strengths of the received signals from the transmitter. These mechanisms cannot rely on the information provided by the transmitter because the latter can be malicious. The best solution presented in the literature to solve this problem is the hyperbolic position bounding algorithm. Unfortunately, it uses an inaccurate approximation of the difference of two log‐normal random variables. When the uncertainty on the effective isotropic radiated power used by the transmitter is high, the hyperbolic position bounding algorithm gives erroneous results. Thus, we propose new algorithms that rely either on better approximations or a geometric interpretation of the problem. We also evaluate the impacts of using multiple independent signals to detect the transmitter. Copyright © 2013 John Wiley & Sons, Ltd.
Smart Nanovehicles Based on pH‐Triggered Disassembly of Supramolecular Peptide‐Amphiphiles for Efficient Intracellular Drug Delivery
Authors: Xu Xianghui , Li Yunkun , Li Haiping , Liu Rong , Sheng Mingming , He Bin , Gu Zhongwei 
Published: October 2013

A novel type of nanovehicle (NV) based on stimuli‐responsive supramolecular peptide‐amphiphiles (SPAs, dendritic poly (L‐lysine) non‐covalently linked poly (L‐leucine)) is developed for intracellular drug delivery. To determine the pH‐dependent mechanism, the supramolecular peptide‐amphiphile system (SPAS) is investigated at different pH conditions using a variety of physical and chemical approaches. The pH‐triggered disassembly of SPAS can be attributed to the disappearance of non‐covalent interactions within SPAs around the isoelectric point of poly (L‐leucine). SPAS is found to encapsulate guest molecules at pH 7.4 but release them at pH 6.2. In this way, SPAS is able to act as a smart NV to deliver its target to tumor cells using intracellular pH as a trigger. The DOX‐loaded NVs are approximately 150 nm in size. In vitro release profiles and confocal laser scanning microscopy (CLSM) images of HepG2 cells confirm that lower pH conditions can trigger the disassembly of NVs and so achieve pH‐dependent intracellular DOX delivery. In vitro cytotoxicity of the DOX‐loaded NVs to HepG2 cells demonstrate that the smart NVs enhance the efficacy of hydrophobic DOX. Fluorescence‐activated cell sorting (FACS) and CLSM results show that the NVs can enhance the endocytosis of DOX into HepG2 cells considerably and deliver DOX to the nuclei.