bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of disease-specific quality of life tools in patients with chronic venous disease
Authors: Kuet Mong-Loon , Lane Tristan RA , Anwar Muzaffar A , Davies Alun H 
Published: August 2013

Objectives This work was presented as a poster in the American Venous Forum 25th Annual Meeting; 28 February 2013; Phoenix, Arizona, USA. Quality of life (QoL) is an important outcome measure in the treatment for chronic venous disease. The Aberdeen Varicose Vein Questionnaire (AVVQ) and the ChronIc Venous Insufficiency quality of life Questionnaire (CIVIQ-14) are two validated disease-specific QoL questionnaires in current use. The aim of this study is to evaluate the relationship between the AVVQ and the CIVIQ-14 to enable better comparison between studies and to compare these disease-specific QoL tools with generic QoL and clinician-driven tools. Methods Adults attending our institution for management of their varicose veins completed the AVVQ, CIVIQ-14 and EuroQol-5D (EQ-5D). Clinical data, CEAP classification and the Venous Clinical Severity Score (VCSS) were collected. The relationship between the AVVQ and CIVIQ-14 scores was analysed using Spearman’s correlation. The AVVQ and CIVIQ-14 scores were also analysed with a generic QoL tool (EQ-5D) and a clinician-driven tool, the VCSS. Results One hundred patients, mean age 57.5 (44 males; 56 females), participated in the study. The median AVVQ score was 21.9 (range 0–74) and the median CIVIQ-14 score was 30 (range 0–89). A strong correlation was demonstrated between the AVVQ and CIVIQ-14 scores ( r = 0.8; p < 0.0001). Strong correlation was maintained for patients with C1-3 disease ( r = 0.7; p < 0.0001) and C4-6 disease ( r = 0.8; p < 0.0001). The VCSS correlated strongly with the AVVQ and CIVIQ-14 scores ( r = 0.7; p < 0.0001 and r = 0.7; p < 0.0001, respectively). Both the AVVQ and CIVIQ-14 scores correlated well with the EQ-5D score ( r = −0.5; p < 0.0001 and r = −0.7; p < 0.0001, respectively). Conclusions This study demonstrates that there is good correlation between two widely used varicose vein specific QoL tools (AVVQ and CIVIQ-14) across the whole spectrum of disease severity. Strong correlation exists between these disease-specific QoL tools and generic and clinician-driven tools. Our findings confirm valid comparisons between studies using either disease-specific QoL tool.
The influence of sprint interval training on body composition, physical and metabolic fitness in adolescents and young adults with intellectual disability: a randomized controlled trial
Authors: Boer Pieter-Henk , Meeus Mira , Terblanche Elmarie , Rombaut Lies , Wandele Inge De , Hermans Linda , Gysel Tineke , Ruige Johannes , Calders Patrick 
Published: August 2013

Objective: In this study we evaluated the effect of sprint interval training on metabolic and physical fitness in adolescents and young adults with intellectual disabilities when compared with continuous aerobic training and no training (control). Methods: Fifty-four persons with intellectual disabilities (age: 17 (3.0), body mass index: 27.7 (3.7), intelligence quotient: 59 (8.6)) were matched based on age, gender and intelligence quotient between sprint interval training ( n = 17), continuous aerobic training ( n = 15) and control ( n = 14). Sprint interval training was composed of three blocks of 10 minutes at ventilatory threshold (blocks 1 and 3: 10 sprint bouts of 15 seconds, followed by 45 seconds relative rest; block 2: continuous training) twice a week for 15 weeks. Continuous aerobic training was composed of three blocks of 10 minutes continuous training. After eight weeks, intensity was increased to 110% of ventilatory threshold. The control group did not participate in supervised exercise training. Before and after the training period, body composition, physical and metabolic fitness were evaluated. Results: Sprint interval training showed a significant positive evolution for waist circumference, fat%, systolic blood pressure, lipid profile, fasting insulin, homeostasis model assessment of insulin resistance, peak VO2, peak Watt, ventilatory threshold, 6-minute walk distance and muscle fatigue resistance when compared with no training ( P < 0.01). The sprint interval training group demonstrated significant improvements for fat%, systolic blood pressure, low-density lipoprotein, fasting insulin, peak VO2 and peak power and ventilatory threshold ( P < 0.01) when compared with continuous aerobic training. Conclusion: In this study we could observe that sprint interval training has stronger beneficial effects on body composition, physical fitness and metabolic fitness compared with control. Compared with continuous aerobic training, sprint interval training seems to result in better outcome.
Stromal fibrosis of the breast: outcome analysis
Authors: Shin Suyoung , Ko Eun Sook , Han Boo-Kyung , Ko Eun Young 
Published: August 2013

Background Stromal fibrosis in the breast is a non-specific benign pathologic entity with wide spectrum of imaging finding. The false-negative rates (number of cancers missed) previously reported have limited value because short follow-up period and small number of populations. Purpose To describe the mammographic and sonographic findings of stromal fibrosis of the breast diagnosed by imaging-guided biopsy and to determine the false-negative rate at percutaneous biopsy. Material and Methods Between January 2007 and December 2008, 3097 consecutive imaging-guided breast core biopsies were performed. Patients were included in our study if stromal fibrosis was the predominant pathologic finding. Patients who had received <2 years of follow-up were excluded. Mammographic and sonographic findings were reviewed. Follow-up imaging for >2 years and histologic data were reviewed to evaluate lesion stability. Results Stromal fibrosis was diagnosed in 187 (6.0%) of 3097 imaging-guided biopsies among patients with >2 years of follow-up (mean, 41.9 months). Among them, 91 (49%) of 187 lesions were not visible on mammography and calcifications were the most common findings, being identified in 33 lesions (17.6%). The most common sonographic finding was an oval hypoechoic mass with a circumscribed margin. Forty-two lesions (22.5%) were excised. Four false-negative lesions (2.1%, 4/187) were identified; all false-negative lesions were diagnosed within 6 months because of imaging-pathology discordance (75%, 3/4) or disease progression (25%, 1/4). Conclusion Stromal fibrosis diagnosed by imaging-guided biopsy has a wide spectrum of imaging finding and can be managed safely with radiologic-pathologic correlation and subsequent short-term imaging follow-up.
Clinical evaluation of thrombus aspiration combined with tirofiban in patients with acute myocardial infarction with elective percutaneous coronary intervention
Authors: Liu Xiangyong , Dong Pingshuan , Xing Shiying , Wang Honglei , Li Zhijuan , Zhang Huifeng , Yang Xuming , Wang Shaoxin , Zhai Qiuling 
Published: August 2013

Objective: To compare the efficacy and safety of combined treatment with thrombus aspiration and intracoronary tirofiban in patients with acute myocardial infarction (MI), with elective percutaneous coronary intervention (PCI). Methods: Patients undergoing elective PCI during recovery from acute MI were randomized into two groups; the intervention group received thrombus aspiration and intracoronary tirofiban; the control group received conventional PCI. Baseline clinical characteristics, postoperative coronary blood flow (thrombolysis in myocardial infarction [TIMI] grade), TIMI myocardial perfusion (TMP) grade, no/slow reflow rate and cardiac function (measured by echocardiography 1 month postoperatively) were evaluated. Major adverse cardiac event rate and bleeding complications during surgery (and at 1 month and 1 year postoperatively) were also evaluated. Results: A total of 80 patients were included. Postoperatively, the number of patients with TIMI flow grade 3 and the mean TMP grade were both significantly higher, and the no/slow reflow rate was significantly lower, in the intervention group versus the control group. Echocardiography indicated that cardiac function was significantly improved in the intervention group compared with the control group. There were no major complications in either study group. Conclusion: Thrombus aspiration combined with intracoronary tirofiban during recovery from acute MI was effective and relatively well tolerated.
A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)
Authors: Chen Yan , He Zhiyi , Meng Su , Li Lei , Yang Hua , Zhang Xiaotang 
Published: August 2013

Objective: Mutations in the high-temperature requirement A serine peptidase 1 ( HTRA1) gene were studied in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Methods: Exons 1–9 of the HTRA1 gene were amplified and bidirectionally sequenced in a Chinese family with CARASIL. Mutation effects were analysed by three-dimensional modelling of the serine protease HTRA1 protein. Results: The proband was found to be homozygous for a novel missense mutation (c.854 C > T) identified in exon 4 of the HTRA1 gene; the parents of the proband were heterozygous for the same missense mutation. This c.854 C > T mutation resulted in a change from proline to leucine (p.P285L) in serine protease HTRA1, and was absent in 260 control chromosomes. Three-dimensional models showed that the change from proline to leucine (p.P285L) could attenuate the hydrogen bond between S284 and S287 residues, which might affect function of serine protease HTRA1. Conclusion: Discovery of a novel missense mutation (c.854C>T) associated with CARASIL expands the known CARASIL-related mutations in HTRA1.
Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks
Authors: Gomez-Mancilla Baltazar , Brand Ronald , Jürgens Tim P , Göbel Harmut , Sommer Claudia , Straube Andreas , Evers Stefan , Sommer Martin , Campos Victor , Kalkman Hans O , Hariry Sam , Pezous Nicole , Johns Donald , Diener Hans-Christoph ,   for the BGG492 Study Group
Published: August 2013

Background Glutamate is implicated in migraine pathophysiology; amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonists represent a potential therapeutic approach because of their anti-excitatory actions. Methods This randomized, double-blind, proof-of-concept study assessed the efficacy of the AMPA receptor antagonist, BGG492 (250 mg), vs placebo and sumatriptan (100 mg), in 75 subjects with acute migraine attacks. Efficacy was measured using the Patient Migraine Diary. Pharmacokinetic and safety data were collected. Results Improvement from severe/moderate to mild/no headache pain (primary response) was reported in 58%, 58%, and 54% of BGG492-treated subjects at 2, 3, and 4 hours post-dose ( p = 0.2, 0.5, and 0.5 vs placebo), respectively, compared with 68%, 84%, and 92% sumatriptan-treated subjects, and 40%, 48%, and 44% in the placebo group. Percentages of subjects with ≥ 2-point improvement in pain score from baseline at 2 hours were 29%, 40%, and 16% for BGG492, sumatriptan, and placebo, respectively. Pain-free response at 2 hours was reported for 25%, 24%, and 16% of BGG492, sumatriptan, and placebo subjects, respectively. Adverse events were reported by 80%, 56%, and 60% of BGG492, sumatriptan, and placebo subjects, respectively. Conclusions Proof-of-concept criterion was not met (≥ 25% BGG492 subjects with a primary response vs placebo at two timepoints). BGG492 was comparable to sumatriptan in terms of pain-free response.
Do Reduction and Healing of the Bony Fragment Really Matter in Arthroscopic Bony Bankart Reconstruction?
Authors: Jiang Chun-Yan , Zhu Yi-Ming , Liu Xin , Li Feng-Long , Lu Yi , Wu Guan 
Published: August 2013

Background: Bony Bankart lesions can be treated with arthroscopic repair. However, few studies have evaluated the importance of bony fragment reduction and healing to stability of the glenohumeral joint after arthroscopic bony Bankart repair. Purpose: To evaluate functional results after surgery and determine the correlation between reduction and healing of the fracture and postoperative stability of the glenohumeral joint. Study Design: Case series; Level of evidence, 4. Methods: A total of 50 patients (47 men, 3 women; average age, 27.6 years; range, 16.5-50.1 years) with bony Bankart lesions and recurrent anterior shoulder dislocations were treated with arthroscopic reduction and internal fixation with suture anchors. The average follow-up period was 32.5 months (range, 24.3-61.2 months). Preoperative and postoperative range of motion and American Shoulder and Elbow Surgeons (ASES), Constant-Murley, and Rowe scores were compared to evaluate the results of the surgeries. Sequential 3-dimensional computed tomography (CT) scans were available for 37 patients and were analyzed to investigate the effect of the bony defect of the glenoid and the correlation between the success of the surgery and reduction and healing of the bony fragment. Results: After surgery, active forward elevation was significantly improved ( P < .05). No significant differences were found regarding external and internal rotations after surgery. The ASES, Constant-Murley, and Rowe scores improved significantly after surgery. Redislocations occurred in 3 patients, and a positive anterior apprehension sign was detected in 1 patient during follow-up. The overall failure rate was 8.0% (4/50). The CT scans during the follow-up period showed a nonunion of the bony fragment in 13.5% of cases (5/37). The reconstructed size of the glenoid was <80% in 3 of the 4 failure cases but >80% in all of the successful cases. Conclusion: Arthroscopic reduction and fixation of a bony Bankart lesion can achieve good results in selected cases. The size of the reconstructed glenoid is crucial to the success of the surgery.
Recognition of International Board Certified Lactation Consultants by Health Insurance Providers in the United States
Authors: Chetwynd Ellen , Meyer Anne-Marie , Stuebe Alison , Costello Rebecca , Labbok Miriam 
Published: August 2013

Background: Insurance coverage for lactation management is proposed by the United States Affordable Care Act. International Board Certified Lactation Consultants (IBCLCs) are key providers of lactation services. In order to inform national discussion, this study examines the scope of insurance reimbursement of IBCLC services. Objectives: An email survey of US IBCLCs (N = 10 495) in March 2011 was used to explore frequencies of (1) submission—how often lactation consults were submitted to insurance providers for reimbursement and (2) recognition—the proportion of submitted charges recognized by insurance providers. Methods: Results (N = 2045) were analyzed to describe patterns of submission and recognition by IBCLC work setting, job classification, and reimbursement strategy. Results: Many survey respondents did not know their submission (41%) or recognition (57%) levels. Multiple strategies were used for reimbursement of IBCLC services with large variations in recognition between strategies. Overall, less than 15% reported high levels of submissions to insurance providers. Moreover, of submitted encounters, only 4% were consistently recognized by insurance providers. Inpatient hospital IBCLCs were least likely to have consults recognized (3%), and private community IBCLCs were most frequently recognized (32%). Compared with using IBCLC credentials for submitting an encounter, using another clinical license was the most successful strategy for achieving recognition of IBCLC consults (crude risk ratio, 1.44; 95% confidence interval, 1.04-2.01; P = .02). Conclusion: IBCLCs provide key care to a vulnerable population. However, we found that these services are not consistently reimbursed. IBCLCs poorly communicate their health care activities to insurance providers, but insurance providers also inconsistently recognize and reimburse IBCLC care.
What is a feral cat?
Authors: Gosling Lara , Stavisky Jenny , Dean Rachel 
Published: August 2013

Study rationale: The definition of a true feral cat is an area of much contention, with many variations used worldwide. In this study, opinions were gathered from feral cat rescue workers and veterinary surgeons working in the United Kingdom to identify a practical definition of a feral cat, suitable for use in the field, education and research. Protocol: A mixed methods approach, using questionnaires and focus groups, was used to collect data from feral cat workers and veterinary surgeons. Findings: Conflicts in opinion on the implications of taming feral cats exist. The rescue workers typically felt that most cats could be tamed, whereas the veterinary surgeons felt this was generally inappropriate, except in the case of young kittens. A consistent definition of feral cats would enable better communication regarding the welfare and management of these animals, and would be useful for further research and education of the public. Proposed definition: A feral cat is proposed by this study to be a cat that is unapproachable in its free-roaming environment and is capable of surviving with or without direct human intervention, and may additionally show fearful or defensive behaviour on human contact.
2013 AAFP Feline Vaccination Advisory Panel Report
Authors: Scherk Margie A , Ford Richard B , Gaskell Rosalind M , Hartmann Katrin , Hurley Kate F , Lappin Michael R , Levy Julie K , Little Susan E , Nordone Shila K , Sparkes Andrew H 
Published: August 2013

Rationale: This Report was developed by the Feline Vaccination Advisory Panel of the American Association of Feline Practitioners (AAFP) to provide practical recommendations to help clinicians select appropriate vaccination schedules for their feline patients based on risk assessment. The recommendations rely on published data as much as possible, as well as consensus of a multidisciplinary panel of experts in immunology, infectious disease, internal medicine and clinical practice.
ISFM Guidelines on Population Management and Welfare of Unowned Domestic Cats (Felis catus)
Authors: Sparkes Andrew H , Bessant Claire , Cope Kevin , Ellis Sarah L H , Finka Lauren , Halls Vicky , Hiestand Karen , Horsford Kim , Laurence Christopher , MacFarlaine Ian , Neville Peter F , Stavisky Jenny , Yeates James 
Published: August 2013

Guidelines rationale: Cats are among the most commonly kept domestic pets, and coexist with humans in a variety of different circumstances. Cats are sentient beings and, as such, humans have a responsibility for cat welfare where humans and cats coexist. Because cats reproduce efficiently, measures to control populations are frequently needed, but these should be based on ethical and humane approaches. Framework: These consensus guidelines from the International Society of Feline Medicine’s Welfare Advisory Panel provide a framework for the approach to welfare and population control measures, primarily among unowned cats and those going through a homing programme.
Retrospective analysis of long-term outcomes in ulna-shortening osteotomy
Authors: Johnston Laura , Chojnowski Adrian 
Published: August 2013

Background There is limited information regarding the long-term outcomes of ulna-shortening osteotomy for ulna impaction syndrome. The Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire is a commonly used patient-rated outcome measure to assess function of the upper limb. The purpose of this retrospective case analysis was to compare patient-reported functional outcome with satisfaction in the assessment of long-term outcome after ulna shorting osteotomy. Methods A study of 32 patients presenting with ulna impaction syndrome with an average assessment of 54 months (range 8–102 months, SD 25.87) following ulna-shortening osteotomy. Outcome was evaluated using the QuickDASH questionnaire and an ordinal patient satisfaction score. Anonymous QuickDASH scores and patient satisfaction scores were obtained for 22 patients, one of whom underwent bilateral ulna-shortening osteotomy and completed individual responses for each procedure, providing us with 23 responses (68% response rate). Results Thirty two patients had an ulna-shortening osteotomy between 2003 and 2012. Fifteen were male (47%) and 17 were female (53%) with an average age at surgery of 43 years (range 15–73, SD 11.27). Two patients underwent bilateral operations. The average QuickDASH score was 22.88 ( n = 23, range 0–72.5, SD 24.22) at follow-up. The average work QuickDASH score was 15.39 (range 0–50, SD 20.74). The average sport QuickDASH score was 34.38 (range 0–81.25, SD 28.89). Patient satisfaction scores showed 87% of patients reported an improvement in symptoms and 61% of patients would definitely recommend the procedure to patients with similar symptoms. Conclusion Long-term outcomes after ulna-shortening osteotomy show high levels of patient satisfaction and low QuickDASH scores.
Nonoperative Treatment Approach to Knee Osteoarthritis in the Master Athlete
Authors: Huleatt Joel B. , Campbell Kevin J. , LaPrade Robert F. 
Published: August 2013

Context: Middle-age and elderly participants in athletic activities frequently encounter the chronic disabling process of osteoarthritis. Knowledge of the treatment of knee osteoarthritis is needed to keep the master athlete active. Objective: This article reviews the current scientific evidence regarding recommendations for the maturing athlete, specifically discussing the strengths and weaknesses of dietary and lifestyle modifications, physical therapy, bracing, supplements, pharmacotherapies, and biologics in the management of knee osteoarthritis. Level of Evidence: Level 4. Conclusion: These treatment modalities can help keep the aging athlete active, which in itself plays an important role in reducing the symptoms of knee osteoarthritis.
Partial IFN-γR2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation
Authors: Moncada-Vélez Marcela , Martinez-Barricarte Rubén , Bogunovic Dusan , Kong Xiao-Fei , Blancas-Galicia Lizbeth , Tirpan Cengiz , Aksu Guzide , Vincent Quentin B. , Boisson Bertrand , Itan Yuval , Ramírez-Alejo Noé , Okada Satoshi , Kreins Alexandra Y. , Bryant Vanessa L. , Franco Jose Luis , Migaud Mélanie , Espinosa-Padilla Sara , Yamazaki-Nakashimada Marco , Espinosa-Rosales Francisco , Kutukculer Necil , Abel Laurent , Bustamante Jacinta , Vogt Guillaume , Casanova Jean-Laurent , Boisson-Dupuis Stéphanie 
Published: August 2013

Key Points
Hypomorphic IFNGR2 alleles encode misfolded proteins with abnormal N-glycosylation. Chemical modifiers of N-glycosylation effectively complemented the patients’ response to IFN-γ.
Preferential splenic CD8+ T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia
Authors: Audia Sylvain , Samson Maxime , Mahévas Matthieu , Ferrand Christophe , Trad Malika , Ciudad Marion , Gautheron Alexandrine , Seaphanh Famky , Leguy Vanessa , Berthier Sabine , Salles Bruno , Martin Laurent , Lorcerie Bernard , Ortega-Deballon Pablo , Facy Olivier , Caillot Denis , Soudry-Faure Agnès , Michel Marc , Godeau Bertrand , Larmonier Nicolas , Saas Philippe , Janikashvili Nona , Bonnotte Bernard 
Published: August 2013

Key Points
Activated CD8+ T cells are preferentially found in the spleen of ITP patients who are nonresponders to rituximab.
Complete moment convergence for randomly weighted sums of martingale differences
Authors: Yang Wenzhi , Wang Yiwei , Wang Xinghui , Hu Shuhe 
Published: August 2013

Abstract
In this article, we obtain the complete moment convergence for randomly weighted sums of martingale differences. Our results generalize the corresponding ones for the nonweighted sums of martingale differences to the case of randomly weighted sums of martingale differences.

MSC:60G50, 60F15.