bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late‐life Depression, Suicidal Ideation, and Attempted Suicide: The Role of Individual Differences in Maximizing, Regret, and Negative Decision Outcomes
Authors: Bruine de Bruin Wändi , Dombrovski Alexandre Y. , Parker Andrew M. , Szanto Katalin 
Published: May 2015

AbstractSuicide rates are highest in adults of middle and older age. Research with psychiatric patients has shown that proneness to feel regret about past decisions can grow so intense that suicide becomes a tempting escape. Here, we examine the additional role of individual differences in maximizing, or the tendency to strive for the best decision, rather than one that is good enough. We provided individual‐difference measures of maximizing, regret proneness, and negative life decision outcomes (as reported on the Decision Outcome Inventory) to a nonpsychiatric control group, as well as three groups of psychiatric patients in treatment for suicide attempts, suicidal ideation, or non‐suicidal depression. We found that scores on the three individual‐difference measures were worse for psychiatric patients than for nonpsychiatric controls and were correlated to clinical assessments of depression, hopelessness, and suicidal ideation. More importantly, maximizing was associated with these clinical assessments, even after taking into account maximizers' worse life decision outcomes. Regret proneness significantly mediated those relationships, suggesting that maximizers could be at risk for clinical depression because of their proneness to regret. We discuss the theoretical relevance of our findings and their promise for clinical practice. Ultimately, late‐life depression and suicidal ideation may be treated with interventions that promote better decision making and regret regulation. Copyright © 2015 John Wiley & Sons, Ltd.
Synthesis of highly fluorescent nitrogen and phosphorus doped carbon dots for the detection of Fe3+ ions in cancer cells
Authors: Chandra Soumen , Laha Dipranjan , Pramanik Arindam , Ray Chowdhuri Angshuman , Karmakar Parimal , Sahu Sumanta Kumar 
Published: May 2015

AbstractHighly fluorescent nitrogen and phosphorus‐doped carbon dots with a quantum yield 59% have been successfully synthesized from citric acid and di‐ammonium hydrogen phosphate by single step hydrothermal method. The synthesized carbon dots have high solubility as well as stability in aqueous medium. The as‐obtained carbon dots are well monodispersed with particle sizes 1.5–4 nm. Owing to a good tunable fluorescence property and biocompatibility, the carbon dots were applied for intercellular sensing of Fe3+ ions as well as cancer cell imaging. Copyright © 2015 John Wiley & Sons, Ltd.
Assessment of tandem mass spectrometry and high‐resolution mass spectrometry for the analysis of bupivacaine in plasma
Authors: Gaudette Fleur , Benito Javier , Steagall Paulo , Beaudry Francis 
Published: May 2015

AbstractTriple quadrupole mass spectrometers coupled with high performance liquid chromatography are workhorses in quantitative bioanalyses. They provide substantial benefits including reproducibility, sensitivity and selectivity for trace analysis. Selected reaction monitoring allows targeted assay development but datasets generated contain very limited information. Data mining and analysis of nontargeted high‐resolution mass spectrometry profiles of biological samples offer the opportunity to perform more exhaustive assessments, including quantitative and qualitative analysis. The objectives of this study were to test method precision and accuracy, to statistically compare bupivacaine drug concentration in real study samples and to verify if high‐resolution and accurate mass data collected in scan mode can actually permit retrospective data analysis, more specifically, extract metabolite related information. The precision and accuracy data presented using both instruments provided equivalent results. Overall, the accuracy ranged from 106.2 to 113.2% and the precision observed was from 1.0 to 3.7%. Statistical comparisons using a linear regression between both methods revealed a coefficient of determination (R2) of 0.9996 and a slope of 1.02, demonstrating a very strong correlation between the two methods. Individual sample comparison showed differences from −4.5 to 1.6%, well within the accepted analytical error. Moreover, post‐acquisition extracted ion chromatograms at m/z 233.1648 ± 5 ppm (M − 56) and m/z 305.2224 ± 5 ppm (M + 16) revealed the presence of desbutyl‐bupivacaine and three distinct hydroxylated bupivacaine metabolites. Post‐acquisition analysis allowed us to produce semi‐quantitative evaluations of the concentration–time profiles for bupicavaine metabolites. Copyright © 2015 John Wiley & Sons, Ltd.
Firms’ Response to Climate Change: The Interplay of Business Uncertainty and Organizational Capabilities
Authors: Lee Su‐Yol , Klassen Robert D. 
Published: May 2015

AbstractWith climate change emerging as one of the most important issues increasing uncertainty in the business circle, firms have shown different reactions. Why do firms differ in adopting and implementing carbon management practices (CMPs) in response to the global warming issue? This paper attempts to explore this question with particular attention to two factors: external business uncertainty and internal organizational capabilities. This study investigated whether business uncertainty, organizational learning and lean production capabilities influenced the adoption and implementation of CMPs as well as examining how organizational capabilities moderate the relationships between business uncertainty and the level of CMPs. The results of a cross‐sectional survey and hierarchical regression analyses indicate that perceived business uncertainty decreases the adoption of CMPs, organizational learning and lean production capabilities strongly facilitate the adoption and implementation of CMPs, and lean production capability positively moderates the impacts of business uncertainty on the adoption of CMPs. This study provides guidance for managers and academics considering how to identify, design and manage the dimensions of a firm's practices in response to the global warming issue within the organization as well as with other organizations. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Crystal Structure of Okadaic Acid Binding Protein 2.1: A Sponge Protein Implicated in Cytotoxin Accumulation
Authors: Ehara Haruhiko , Makino Marie , Kodama Koichiro , Konoki Keiichi , Ito Takuhiro , Sekine Shun‐ichi , Fukuzawa Seketsu , Yokoyama Shigeyuki , Tachibana Kazuo 
Published: May 2015

AbstractOkadaic acid (OA) is a marine polyether cytotoxin that was first isolated from the marine sponge Halichondria okadai. OA is a potent inhibitor of protein serine/threonine phosphatases (PP) 1 and 2A, and the structural basis of phosphatase inhibition has been well investigated. However, the role and mechanism of OA retention in the marine sponge have remained elusive. We have solved the crystal structure of okadaic acid binding protein 2.1 (OABP2.1) isolated from H. okadai; it has strong affinity for OA and limited sequence homology to other proteins. The structure revealed that OABP2.1 consists of two α‐helical domains, with the OA molecule deeply buried inside the protein. In addition, the global fold of OABP2.1 was unexpectedly similar to that of aequorin, a jellyfish photoprotein. The presence of structural homologues suggested that, by using similar protein scaffolds, marine invertebrates have developed diverse survival systems adapted to their living environments.
Activity of α‐Aminoadipate Reductase Depends on the N‐Terminally Extending Domain
Authors: Kalb Daniel , Lackner Gerald , Rappe Marcus , Hoffmeister Dirk 
Published: May 2015

AbstractL‐α‐Aminoadipic acid reductases catalyze the ATP‐ and NADPH‐dependent reduction of L‐α‐aminoadipic acid to the corresponding 6‐semialdehyde during fungal L‐lysine biosynthesis. These reductases resemble peptide synthetases with regard to their multidomain composition but feature a unique domain of elusive function—now referred to as an adenylation activating (ADA) domain—that extends the reductase N‐terminally. Truncated enzymes based on NPS3, the L‐α‐aminoadipic acid reductase of the basidiomycete Ceriporiopsis subvermispora, lacking the ADA domain either partially or entirely were tested for activity in vitro, together with an ADA‐adenylation didomain and the ADA domainless adenylation domain. We provide evidence that the ADA domain is required for substrate adenylation: that is, the initial step of the catalytic turnover. Our biochemical data are supported by in silico modeling that identified the ADA domain as a partial peptide synthetase condensation domain.
Structural Integrity of the A147T Polymorph of Mammalian TSPO
Authors: Jaremko Mariusz , Jaremko Łukasz , Giller Karin , Becker Stefan , Zweckstetter Markus 
Published: May 2015

AbstractLigands of the transmembrane protein TSPO are used for imaging of brain inflammation, but a common polymorphism in TSPO complicates their application to humans. Here we determined the three‐dimensional structure and side‐chain dynamics of the A147T polymorph of mammalian TSPO in complex with the first‐generation ligand PK11195. We show that A147T TSPO is able to retain the same structural and dynamic profile as the wild‐type protein and thus binds PK11195 with comparable affinity. Our study is important for the design of more potent diagnostic and therapeutic ligands of TSPO.
Visible‐Light‐Assisted Selective Catalytic Reduction of Nitric Oxide with Ammonia over Dye‐Modified Titania Photocatalysts
Authors: Yamamoto Akira , Teramura Kentaro , Hosokawa Saburo , Shishido Tetsuya , Tanaka Tsunehiro 
Published: May 2015

AbstractDye‐modified TiO2 photocatalysts showed a high photocatalytic activity for the selective catalytic reduction of NO with NH3 in the presence of O2 under visible‐light irradiation. Among the 15 dyes investigated, the maximum conversion was achieved using a Ru(2,2′‐bipyridyl‐4,4′‐dicarboxylic acid)2(NCS)2 complex (N3‐dye) for the modification of TiO2 (NO conversion >99 %, N2 selectivity >99 %). Diffuse reflectance infrared Fourier transform spectroscopy showed that nitrite (NO2−) and nitrate (NO3−) species were generated on the N3‐TiO2 surface under visible‐light irradiation. In gas‐switching reactions, NO2− on the N3‐TiO2 surface became N2 by a reaction with adsorbed NH3 under visible‐light irradiation, although NO3− reacted with NH3 to form N2 and N2O. Based on the reactivity with NH3, we concluded that the NO2− species is an intermediate in the selective photocatalytic reduction and reacts with NH3 adsorbed on the surface of N3‐TiO2 under visible‐light irradiation to form N2 selectively.
Green Synthesis of Rice Bran Microsphere Catalysts Containing Natural Biopromoters
Authors: Sun Jian , Xu Hengyong , Liu Guoguo , Zhu Pengfei , Fan Ronggang , Yoneyama Yoshiharu , Tsubaki Noritatsu 
Published: May 2015

AbstractThe application of rice‐bran catalysts containing “biopromoters”, from rice bran, in the production of synthetic oil was investigated. Trace minerals such as K, Mg, and Mn from rice bran were successfully incorporated into Fe@C microspherical cores and played a cooperative promotional role on the iron species. The yield of the hydrocarbons was strikingly higher than that obtained with the unpromoted catalyst. Further, rice bran is a natural carbon source, not a chemical carbon source, that can be used to fabricate the carbon microsphere support. This concept opens a new avenue for recycling and boosts the value of abundant waste biomass in nature.
Luminescent Di‐ and Trinuclear Boron Complexes Based on Aromatic Iminopyrrolyl Spacer Ligands: Synthesis, Characterization, and Application in OLEDs
Authors: Suresh D. , Gomes Clara S. B. , Lopes Patrícia S. , Figueira Cláudia A. , Ferreira Bruno , Gomes Pedro T. , Di Paolo Roberto E. , Maçanita António L. , Duarte M. Teresa , Charas Ana , Morgado Jorge , Vila‐Viçosa Diogo , Calhorda Maria José 
Published: May 2015

AbstractNew bis‐ and tris(iminopyrrole)‐functionalized linear (1,2‐(HNC4H3‐C(H)N)2‐C6H4 (2), 1,3‐(HNC4H3‐C(H)N)2‐C6H4 (3), 1,4‐(HNC4H3‐C(H)N)2‐C6H4 (4), 4,4′‐(HNC4H3‐C(H)N)2‐(C6H4‐C6H4) (5), 1,5‐(HNC4H3C‐(H)N)2‐C10H6 (6), 2,6‐(HNC4H3C‐(H)N)2‐C10H6 (7), 2,6‐(HNC4H3C‐(H)N)2‐C14H8 (8)) and star‐shaped (1,3,5‐(HNC4H3‐C(H)N‐1,4‐C6H4)3‐C6H3 (9)) π‐conjugated molecules were synthesized by the condensation reactions of 2‐formylpyrrole (1) with several aromatic di‐ and triamines. The corresponding linear diboron chelate complexes (Ph2B[1,3‐bis(iminopyrrolyl)‐phenyl]BPh2 (10), Ph2B[1,4‐bis(iminopyrrolyl)‐phenyl]BPh2 (11), Ph2B[4,4′‐bis(iminopyrrolyl)‐biphenyl]BPh2 (12), Ph2B[1,5‐bis(iminopyrrolyl)‐naphthyl]BPh2 (13), Ph2B[2,6‐bis(iminopyrrolyl)‐naphthyl]BPh2 (14), Ph2B[2,6‐bis(iminopyrrolyl)‐anthracenyl]BPh2 (15)) and the star‐shaped triboron complex ([4′,4′′,4′′′‐tris(iminopyrrolyl)‐1,3,5‐triphenylbenzene](BPh2)3 (16)) were obtained in moderate to good yields, by the treatment of 3–9 with B(C6H5)3. The ligand precursors are non‐emissive, whereas most of their boron complexes are highly fluorescent; their emission color depends on the π‐conjugation length. The photophysical properties of the luminescent polyboron compounds were measured, showing good solution fluorescence quantum yields ranging from 0.15 to 0.69. DFT and time‐dependent DFT calculations confirmed that molecules 10 and 16 are blue emitters, because only one of the iminopyrrolyl groups becomes planar in the singlet excited state, whereas the second (and third) keeps the same geometry. Compound 13, in which planarity is not achieved in any of the groups, is poorly emissive. In the other examples (11, 12, 14, and 15), the LUMO is stabilized, narrowing the gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital (HOMO–LUMO), and the two iminopyrrolyl groups become planar, extending the size of the π‐system, to afford green to yellow emissions. Organic light‐emitting diodes (OLEDs) were fabricated by using the new polyboron complexes and their luminance was found to be in the order of 2400 cd m−2, for single layer devices, increasing to 4400 cd m−2 when a hole‐transporting layer is used.
Protonation and Proton‐Coupled Electron Transfer at S‐Ligated [4Fe‐4S] Clusters
Authors: Saouma Caroline T. , Morris Wesley D. , Darcy Julia W. , Mayer James M. 
Published: May 2015

AbstractBiological [Fe‐S] clusters are increasingly recognized to undergo proton‐coupled electron transfer (PCET), but the site of protonation, mechanism, and role for PCET remains largely unknown. Here we explore this reactivity with synthetic model clusters. Protonation of the arylthiolate‐ligated [4Fe‐4S] cluster [Fe4S4(SAr)4]2− (1, SAr=S‐2,4‐6‐(iPr)3C6H2) leads to thiol dissociation, reversibly forming [Fe4S4(SAr)3L]1− (2) and ArSH (L=solvent, and/or conjugate base). Solutions of 2+ArSH react with the nitroxyl radical TEMPO to give [Fe4S4(SAr)4]1− (1ox) and TEMPOH. This reaction involves PCET coupled to thiolate association and may proceed via the unobserved protonated cluster [Fe4S4(SAr)3(HSAr)]1− (1‐H). Similar reactions with this and related clusters proceed comparably. An understanding of the PCET thermochemistry of this cluster system has been developed, encompassing three different redox levels and two protonation states.
Labeling Strategy and Signal Broadening Mechanism of Protein NMR Spectroscopy in Xenopus laevis Oocytes
Authors: Ye Yansheng , Liu Xiaoli , Chen Yanhua , Xu Guohua , Wu Qiong , Zhang Zeting , Yao Chendie , Liu Maili , Li Conggang 
Published: May 2015

AbstractWe used Xenopus laevis oocytes, a paradigm for a variety of biological studies, as a eukaryotic model system for in‐cell protein NMR spectroscopy. The small globular protein GB1 was one of the first studied in Xenopus oocytes, but there have been few reports since then of high‐resolution spectra in oocytes. The scarcity of data is at least partly due to the lack of good labeling strategies and the paucity of information on resonance broadening mechanisms. Here, we systematically evaluate isotope enrichment and labeling methods in oocytes injected with five different proteins with molecular masses of 6 to 54 kDa. 19F labeling is more promising than 15N, 13C, and 2H enrichment. We also used 19F NMR spectroscopy to quantify the contribution of viscosity, weak interactions, and sample inhomogeneity to resonance broadening in cells. We found that the viscosity in oocytes is only about 1.2 times that of water, and that inhomogeneous broadening is a major factor in determining line width in these cells.
Guapsidial A and Guadials B and C: Three New Meroterpenoids with Unusual Skeletons from the Leaves of Psidium guajava
Authors: Jian Yu‐Qing , Huang Xiao‐Jun , Zhang Dong‐Mei , Jiang Ren‐Wang , Chen Min‐Feng , Zhao Bing‐Xin , Wang Ying , Ye Wen‐Cai 
Published: May 2015

AbstractA novel sesquiterpene‐based Psidium meroterpenoid, possessing an unusual coupling pattern, and two new monoterpene‐based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava. Their structures and absolute configurations were elucidated by spectroscopic, X‐ray diffraction, and computational methods. The plausible biosynthetic pathway of these meroterpenoids as well as their cytotoxicities toward HepG2 and HepG2/ADM cells were also discussed.
Synthesis of Peptide‐Based Hybrid Nanobelts with Enhanced Color Emission by Heat Treatment or Water Induction
Authors: Liu Xingcen , Zhu Pengli , Fei Jinbo , Zhao Jie , Yan Xuehai , Li Junbai 
Published: May 2015

AbstractWe demonstrate that an inorganic lanthanide ion (Tb3+) or organic dye molecules were encapsulated in situ into diphenylalanine (FF) organogels by a general, simple, and efficient co‐assembly process, which generated peptide‐based hybrid nanobelts with a range of colored emissions. In the presence of a photosensitizer (salicylic acid), the organogel can serve as an excellent molecular‐donor scaffold to investigate FRET to Tb3+. More importantly, heat treatment or water induction instigated a morphology transition from nanofibers to nanobelts, after which the participation of guest molecules in the FF assembly was promoted and the stability and photoluminescence emission of the composite organogels were enhanced.
Carbon‐11 Radiolabelling of Organosulfur Compounds: 11C Synthesis of the Progesterone Receptor Agonist Tanaproget
Authors: Haywood Tom , Kealey Steven , Sánchez‐Cabezas Santiago , Hall James J. , Allott Louis , Smith Graham , Plisson Christophe , Miller Philip W. 
Published: May 2015

AbstractHerein a new 11C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, 11CS2, is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [11C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with 11CS2, which has potential applications as a positron emission tomography radioligand for cancer imaging.
Stereoselective Peterson Olefinations from Bench‐Stable Reagents and N‐Phenyl Imines
Authors: Das Manas , Manvar Atul , Jacolot Maïwenn , Blangetti Marco , Jones Roderick C. , O'Shea Donal F. 
Published: May 2015

AbstractInvited for the cover of this issue is the group of Donal F. O’Shea at the Royal College of Surgeons in Ireland. The image depicts the facade of the original building of the Royal College of Surgeons in Ireland, which has housed the chemistry department since its foundation in 1828. Read the full text of the article at 10.1002/chem.201500475.
A Helical Polyphenylacetylene Having Amino Alcohol Moieties Without Chiral Side Groups as a Chiral Ligand for the Asymmetric Addition of Diethylzinc to Benzaldehyde
Authors: Liu Lijia , Long Qing , Aoki Toshiki , Zhang Geng , Kaneko Takashi , Teraguchi Masahiro , Zhang Chunhong , Wang Yudan 
Published: May 2015

AbstractOne‐handed helical polyphenylacetylenes having achiral amino alcohol moieties, but no chiral side groups, were synthesized by the helix‐sense‐selective copolymerization of an achiral phenylacetylene having an amino alcohol side group with a phenylacetylene having two hydroxyl groups. Since the resulting helical copolymers were successfully utilized as chiral ligands for the enantioselective alkylation of benzaldehyde with diethylzinc, we can conclude that the main‐chain chirality based on the one‐handed helical conformation is useful for the chiral catalysis of an asymmetric reaction for the first time. The enantioselectivities of the reaction were controlled by the optical purities of the helical polymer ligands. In addition, the polymer ligands could be easily recovered by precipitation after the reaction. Chirality 27:454–458, 2015. © 2015 Wiley Periodicals, Inc.
User cooperation effects on firm's innovation outputs
Authors: Sánchez‐González Gloria , Herrera Liliana 
Published: May 2015

AbstractWe analyzed the effects of R&D cooperation with users and the intensity/continuity of such cooperation on firms' innovation output—whether radical or incremental. We also examined the moderating effect of firm size on these relationships. Results show that cooperation with users favours the development of both radical and incremental product innovations. In addition, we found that the higher the intensity/continuity of the relationship with users, the more likely radical innovations are to develop when compared with incremental innovations. We note that the positive effect of cooperation on the development of innovation is especially significant for small firms. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
Beneficial Effects of Positive Airway Pressure Therapy for Sleep‐Disordered Breathing in Heart Failure Patients With Preserved Left Ventricular Ejection Fraction
Authors: Yoshihisa Akiomi , Suzuki Satoshi , Yamauchi Hiroyuki , Sato Takamasa , Oikawa Masayoshi , Kobayashi Atsushi , Yamaki Takayoshi , Sugimoto Koichi , Kunii Hiroyuki , Nakazato Kazuhiko , Suzuki Hitoshi , Saitoh Shu‐Ichi , Takeishi Yasuchika 
Published: May 2015

ABSTRACTBackgroundRight‐heart dysfunction is associated with poor prognosis in heart failure with preserved left ventricular ejection fraction (HFpEF). It remains unclear whether sleep‐disordered breathing (SDB) treatment using positive airway pressure (PAP) improves right‐heart and pulmonary function and exercise capacity and reduces mortality rates of HFpEF patients.HypothesisPAP may improve right‐heart and pulmonary function, exercise capacity and prognosis in HFpEF patients with SDB.MethodsOne hundred nine consecutive patients with HFpEF (left ventricular ejection fraction >50%) and moderate to severe SDB (apnea‐hypopnea index ≥15/h) treated with medications were divided into 2 groups: 31 patients with PAP (PAP group) and 78 patients without PAP (non‐PAP group). Right ventricular fractional area change (RV‐FAC), tricuspid valve regurgitation pressure gradient (TR‐PG), tricuspid valve E/E′, forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC), percentage of vital capacity, and peak VO2 were determined before and 6 months later, and all‐cause mortality was followed up for 916 days.ResultsAll parameters improved in the PAP group (RV‐FAC, 36.0% –46.5%; TR‐PG, 31.1 mm Hg–22.4 mm Hg; tricuspid valve E/E′, 7.8–5.1; FEV1/FVC, 83.9%–89.8%; percentage of vital capacity, 83.5%–89.9%; and peak VO2, 16.6 mL/kg/min–19.6 mL/kg/min; P <0.05, respectively) but not in the non‐PAP group. Importantly, all‐cause mortality was significantly lower in the PAP group than in the non‐PAP group (0% vs 12.8%; log‐rank P = 0.014).ConclusionsPositive airway pressure improves right‐heart and pulmonary function and exercise capacity and may reduce all‐cause mortality in patients with HFpEF and SDB.