bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life among inpatients suffering from Traumatic brain injury in an urban setting in Vietnam
Authors: Vu Hai Minh , Duong Nam Nhu , Nguyen Cuong Duy , Vu Linh Gia , Nguyen Hien Thu , Tran Tung Hoang 
Published: August 2024

Background
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity globally. This study aimed to measure the health-related quality of life (HRQOL) of TBI patients in Vietnam and evaluate the associated factors.

Methods
A longitudinal study was conducted in Thai Binh, Vietnam, from February to September 2020. The EuroQol-5 Dimensions-5 Levels (EQ-5D-5L) and EQ-Visual Analog Scale (EQ-VAS) were used to measure HRQOL. Socio-demographic characteristics, including age, gender, education level, employment status, marital status, and income, as well as clinical characteristics such as injury severity, cause of injury, comorbidities, and functional status, were collected through patient interviews and medical records. Multivariate Tobit regression analysis was performed to identify variables associated with HRQOL.

Results
The study included 212 TBI patients. The mean scores of the VAS and EQ-5D-5L scales were 82.4/100 (SD = 14.49) and 0.9/1.0 (SD = 0.2), respectively, indicating a relatively high HRQOL. However, certain factors significantly impacted HRQOL. Unemployed patients and those with depression or higher injury severity, as measured by the Injury Severity Score (ISS), had notably lower HRQOL scores. Poor sleep quality and severe functional impairments also adversely affected HRQOL, whereas patients discharged for a longer period had slightly better HRQOL scores.

Conclusion
This study highlights that while HRQOL is relatively high among TBI patients, mental health disorders, injury severity, and functional impairments are key factors negatively impacting their quality of life. High HRQOL was defined by mean scores on the VAS and EQ-5D-5L scales, with higher scores indicating better quality of life. Home-based interventions addressing these issues could improve HRQOL for TBI patients.
Computational analysis of nanoparticles and waste discharge concentration past a rotating sphere with Lorentz forces
Authors: Nimmy Pullare , Obalalu Adebowale Martins , Nagaraja Kallur Venkat , Madhukesh Javali Kotresh , Khan Umair , Ishak Anuar , Sriram Devanathan , Hussain Syed Modassir , Kumar Raman , Abed Ahmed M. 
Published: August 2024

Abstract
As industries rely more and more on magnetohydrodynamic (MHD) systems for different uses in power, production, and management of the environment, it becomes essential to optimize these operations. The study seeks to improve the effectiveness and productivity of cooling structures, chemical reaction reactors, and contaminant control methods by investigating these intricate interconnections. Because of this, the work scrutinizes the endothermic/exothermic (EN/EX) chemical processes, convective boundary conditions, and pollutant concentration impacts on MHD nanofluid circulation around a rotating sphere. The governing equations based on the above assumptions are reduced into a system of ordinary differential equations and solved numerically with Runge–Kutta Fehlberg’s fourth- and fifth- order schemes. The obtained numerical outcomes from the numerical scheme are presented with the aid of graphs, and the results show that the rate of mass transfer decreases with an increase in the external pollutant local source and solid volume percentage. For changes in the values of the activation energy parameter and solid fraction, the rate of thermal dispersion drops for the EN case and upsurges for the EX case. The concentration profile shows increment with the addition of the external pollutant source variation parameter and local pollutant external source parameter. The outcomes of the present work can be helpful in cooling equipment, developing advanced methods for controlling pollution, environmental management, MHD generators, and various industrial contexts.
English Medium Instruction or Exploitative Models of Income? International students’ experiences of EMI by default at an Australian university
Authors: Steele Carly , Tankosić Ana , Dovchin Sender 
Published: August 2024

Abstract
International education is Australia’s largest services export, and third largest export altogether, generating between $22 billion and $40 billion per year over the last few years. Higher education represents half of this ‘market’ with over 25 % of students being from overseas. Despite the important role that international students play in the fabric of Australian society and specifically in higher education, the findings from our linguistic ethnographic study of international students at an Australian university showed that the English language learning needs of these students were frequently unmet. Using James Scott’s theory of official and hidden transcripts, we reveal that students reported feeling that their “English is not good enough” and assumed personal ‘(ir)responsibility’ for this outcome. In this broad English Medium Instruction (EMI) context, where English is not the first language, but it is used as the language of instruction and as the lingua franca amongst international students, English-dominant perspectives acted to marginalise international students, impacting their academic performance and confidence for social networking. In this paper, we describe the shifts in higher educational policy in Australia over the last few decades to provide context to the current neoliberal educational climate for international students. We draw on principles of social justice to examine the present-day system and argue that Australian universities need to shift from an EMI by default model to a genuine EMI offering.
Hepatotoxicity of nanomaterials: From mechanism to therapeutic strategy
Authors: Gao Chengtian , Wang Mingdong , Zheng Yali , Zhang Liang , He Jiawei , Liu Bosen , Lin Xinhua , Mao Jingsong , Wang Zhanxiang 
Published: August 2024

Abstract
Most nanoparticles are metabolized and accumulated in the liver; therefore, this review, based on most data collected from PubMed.gov between 2012 and 2023 with the keywords “nanomaterials induced hepatotoxicity,” aims to elucidate the mechanism of nanoparticles leading to liver injury and propose relevant strategies. We discuss the biomedical approaches and strategies for mitigating liver injury, including 1) principle and recommendation of material selection; 2) nanoparticle surface modulation; 3) strategies inspired by virus and other biological phenomenon; and 4) drug and other possible adjunctive strategies. The optimal design of nanomaterials and therapeutic strategies to attenuate hepatotoxicity is critical for the development of nanomedicine.
High-throughput digital imaging and detection of morpho-physiological traits in tomato plants under drought
Authors: Kovár Marek , Živčák Marek , Filaček Andrej , Jasenovská Lucia , Vukelić Igor , Panković Dejana , Bárek Viliam , Yang Xinghong , Brestič Marián 
Published: August 2024

Abstract
Advances in informatics, robotics, and imaging techniques make it possible to use state-of-the-art digital reconstruction technologies for high-throughput plant phenotyping (HTPP) affected by stress factors, as well as for the ontology of their structural and functional traits. Digital imaging of structural and functional features of the aboveground part of plants is non-destructive and plants can be monitored throughout their entire life cycle. In the experiment with tomato plants (Solanum lycopersicum L.; cv. Gruzanski zlatni) grown in controlled environmental conditions and affected by gradual soil dehydration, we evaluated phenotypic traits and phenotypic plasticity by the PlantScreenTM platform using digital imaging of plant optical signals. In this study, 25 different morpho-physiological traits of the plant were evaluated during the precise control and monitoring of the water content in the soil. Different levels of plant water supply induced statistically significant differences in the formation of individual phenotypic traits. Several plant traits have been identified that are characterized by low variability in both well-hydrated and water-stressed conditions, as well as traits with high phenotypic plasticity. Geometric traits (especially Isotop, Round-2top, and Compside) showed a relatively low level of drought-induced phenotypic plasticity. However, functional and chemometric characteristics (ΔF/F′m, Rfd, Water-1, and ARI-1) showed the potential to exhibit rapid plasticity in water-stressed conditions. Our results confirmed that a high-throughput phenotyping methodology coupled with advanced statistical analysis tools can be successfully applied to characterize crop stress responses and identify traits associated with crop stress tolerance.
Sportliche Bewegung zwischen Verhaltens- und Kulturwissenschaft: von Perspektivität, Vorannahmen, Randbedingungen und intertheoretischen Bändern
Authors: Hossner Ernst-Joachim 
Published: August 2024

Zusammenfassung
Ausgehend von dem von Schürmann und Hossner (2012a, b) vorgeschlagenen Perspektivitätsansatz wird argumentiert, dass sich sportwissenschaftliche (Teil-)Disziplinen um die Identifikation von intertheoretischen Bändern bemühen mögen, die als Randbedingungen in die eigene Theoriebildung einzubeziehen sind. Unter Anerkennung der verhaltensorientiert-funktionalistischen Ausrichtung der Motorikwissenschaft wird zudem untersucht, ob die aktuelle Motoriktheorie mit ihrer Hervorhebung interner Prädiktionsprozesse eine ‚Andockstelle‘ bereithält, die im Spannungsfeld von Bedeutungszuschreibung und Bedeutungsvermitteltheit eine wechselseitig bereichernde Bezugnahme verhaltensbezogen-motorikwissenschaftlicher und anthropologisch-kulturwissenschaftlicher Perspektiven auf die menschliche Bewegung erlaubt.
QUANDO O FOGO NÃO QUEIMA, QUANDO A DECAPITAÇÃO NÃO MATA:CAUSALIDADE NO TAHAFUT AL-FALASIFA XVII, DE AL-GHAZALI
Authors: Verza Tadeu Mazzola 
Published: August 2024

Este artigo aborda se a discussão XVII do Tahafut al-falasifa pode fornecer elementos para se obter qual seria a noção ghazaliana de causalidade apesar da natureza eminentemente disputativa da obra. O artigo sugere uma leitura do texto em que al-Ghazali, ao considerar haver dois sistemas alternativos de explicação da causalidade no mundo (o dos filósofos e o que incorpora uma noção forte de vontade divina), ambos não demonstrados, defenderia que a participação divina na relação entre causa e causado seria preferível à um necessitarismo estrito ou mitigado dos filósofos devido à possibilidade do milagre.
NIETZSCHE, LEITOR DE PASCAL: “O ÚNICO CRISTÃO LÓGICO”
Authors: Lebreton Lucie 
Published: August 2024

Este artigo mostra a importância de Pascal no pensamento de Nietzsche, através da análise da expressão “cristão lógico”, que ele especificamente dedica a ele. Segundo Nietzsche, a figura icônica de Port-Royal personifica o conflito entre o cristianismo e a moral derivada dele e, portanto, entre a fé cristã e a probidade científica, ambas ligadas pela ideia de que Deus é a verdade, que a verdade é divina. Como ele considera seu próprio pensamento como um caminho para o cristianismo se superar, Nietzsche não hesita em considerar Pascal como um de seus precursores.
DA FILOSOFIA DA NATUREZA À FILOSOFIA MORAL: ANÁLISE DE UMA ÉTICA ANIMAL EM HANS JONAS
Authors: Sganzerla Anor , Xavier Bruno Henrique do Rosario 
Published: August 2024

As últimas décadas têm testemunhado uma profusão de teorias filosóficas que buscam reconhecer a moralidade de uma categoria tradicionalmente compreendida como neutra: os animais. Destituída de qualquer valor, a existência não-humana senciente foi deixada de lado por grandes nomes da ética ocidental (de Aristóteles a Kant), cujas teorias colocava-os, muitas vezes, sob o mesmo status de mera matéria destituída de vida. Contudo, desde o século XVIII, sobretudo na Inglaterra, os animais passaram a fazer parte do escopo compreendido por um sem-número de teorias éticas comprometidas com o desafio de lidar com a problemática relação imposta entre humanos e animais. Partindo de um postulado comum – um agente é moralmente relevante se dispõe do maquinário biológico necessário para a produção de sensações agradáveis ou desagradáveis – tais percepções falham em reconhecer a existência de outros seres carentes de proteção moral: as árvores, plantas e uma infinidade de organismos com sistema nervoso central particularmente rudimentar para entrar dentro do cálculo utilitarista, cuja existência encontra-se igualmente ameaçada pelo poder de ação humana. Tendo esse desafio como norte, o presente artigo busca, a partir da teoria ética de Hans Jonas voltada aos animais, uma alternativa de proteção da vida extra-humana e da biosfera. Trata-se de uma pesquisa bibliográfica de caráter analítico, cuja fonte principal circula, sobretudo, em torno de duas grandes obras do filósofo: O Princípio Vida e O Princípio Responsabilidade. Assim sendo, pergunta-se: em que medida a teoria da responsabilidade jonasiana oferece fundamentos para pensar uma teoria ética para os animais não-humanos, ao mesmo tempo que não exclui da esfera moral outros seres vivos? Tal problemática certamente precisa operar sob a perspectiva de uma filosofia da natureza, para então estabelecer um alicerce teórico sobre o qual se possa construir uma ética animal. Para tanto, o texto divide-se em três seções: a) primeiro analisa-se a pertença humana no reino natural, possibilitada, segundo Jonas, graças ao sucesso do darwinismo enquanto narrativa descritiva da realidade biológica; b) passa-se então para uma análise da ontologia da natureza de Jonas compreendendo desde a mais primitiva existência unicelular ao mais desenvolvido degrau da vida animal; c) para então desembocar em uma teoria ética da responsabilidade que compreenda tanto a existência humana, quanto a não-humana. Em seu degrau ascendente de valor, a vida reivindica uma responsabilidade em determinados níveis, tendo a existência animal, com o dramático aparecimento das sensações, mobilidade, medo e desejo, uma reivindicação mais ampla em relação aos modos mais primitivos de manifestação da vida.
Conhecimento sobre diabetes mellitus tipo 2 de mulheres em diferentes ciclos femininos
Authors: Ferreira Christini Gomes Senhorinho , Matos Talita Batista , Cunha Sheila Silva , Santos Maria Luiza Barreto Souza , Santos Luíza Gabriela dos , Milagres Maria Patrícia 
Published: August 2024

Objetivo: analisar o conhecimento de mulheres em diferentes ciclos femininos em relação ao diabetes mellitus tipo 2. Métodos: estudo transversal realizado com 46 mulheres com diabetes tipo 2. Os dados foram coletados por meio de formulário sociodemográfico e clínico e do teste de conhecimento sobre a doença, além da avaliação antropométrica. Para analisar o conhecimento sobre a doença, realizou-se média ± desvio‑padrão considerando o escore total das participantes e de cada ciclo feminino. Visando comparar o conhecimento dos ciclos femininos, foi realizado o teste t para amostras independentes. Resultados: o conhecimento sobre a doença teve média de 6,7±2,3 pontos, e 56,5% das entrevistadas apresentaram pouco conhecimento, com destaque para a cetonúria, substituição de alimentos e desconhecimento das causas e cuidados com a hipoglicemia. Mulheres no climatério/menopausa apresentaram conhecimento com escore médio maior (7,5±2,8) quando comparadas àquelas na pós‑menopausa (6,15±1,8), sem diferença estatística significante (p=0,056). Conclusão: as mulheres com diabetes tipo 2 mostraram pouco conhecimento sobre a doença independentemente do ciclo feminino, o que pode gerar impactos no gerenciamento da doença. Contribuições para a prática: os dados são essenciais para intervenções e educação em saúde das mulheres com diabetes e no cuidado do controle da doença.
Method for obtaining ecological products from rainbow trout Oncorhynchus mykiss farming
Authors: Honcharova O. 
Published: August 2024

In aquaculture, the period of active development of aquatic organisms is considered one of the most important for the formation of potential in the future. The issue of using natural components when growing aquatic organisms and feeding young fish is given special attention. This research investigated Spirulina (25%) + Vermiculture (50%) + Hermetia illucens (25%) as an additional source of functional active substances and protein that affect the body performance of rainbow trout in early ontogenesis. All objects were cultured in a special bioreactor, which was a component of the recirculating aquaculture model system as well as in the laboratory, where an installation was made for cultivating natural food. The results of the scientific and practical part of the work showed that after the end of the experiment, body weight was higher in the experimental fish by 7.2% than in the control group. This article presents the results of feeding rainbow trout as one of the cases of improving the morpho-functional and biochemical composition of the blood of this species: an increase in the total number of red blood cells by 11.0%, hemoglobin content by 9.7%, total protein at 22.7%, albumin by 24.2%, and creatinine by 15.5%, compared with the control group. The presented positive changes in the functional status of the rainbow trout organism were in harmony with the parameters of body weight, as well as histological indicators. Histological indicators of the liver and muscle tissue of the fish supplemented the obtained positive result of the influence of natural and active components of the feed. Feeding fish according to the scheme in the experimental group promotes the formation of layers of special adipose tissue in the endomysium. The total amount of the stromal component in the muscle tissue of rainbow trout was 25% of the mass of the entire tissue. The control group showed that the muscle fibers were polygonal in cross section, separated from each other within the bundle by delicate layers of endomysium. When using a standard feeding regimen (control group), the stromal component is a moderately expanding structure that replaces the space between the fibers. The experimental group had the most significant indicators. The intensification of individual aspects of homeostasis achieved with the help of feed components (experimental group) promotes the growth of muscle fibers in thickness due to the formation of new fibrils, but not an increase in the proportion of sarcoplasm (watery meat). As a result, neurohumoral regulation and substance synthesis processes improved in the fishes’ body, which helps to improve ontogenesis rates. The presented ingredients in the diet of rainbow trout are natural stimulants of metabolic processes and sources of nutrients. The method allows aquaculture to be defined as being as close as possible to “environmentally safe”. The next stage will be a comprehensive analysis of the qualitative and quantitative characteristics of rainbow trout meat under the influence of the feed factor.
In silico exploration of antinociceptive activity of 1,4-benzodiazepines: Molecular docking on α1 A-adrenoceptor, and phosphodiesterase 4
Authors: Akisheva A. S. , Larionov V. B. , Golovenko M. Y. , Makarenko O. A. , Valivodz I. P. , Borysiuk I. Y. , Molodan Y. O. 
Published: August 2024

Recently, scientists have established that several benzodiazepines were found to enhance the activation of a cAMP response element pathway by α1A-adrenergic receptors, but this effect was attributed to off-target inhibition of phosphodiesterases 4. The study explores the pain-relief potential of 1,4-benzodiazepines using in silico methods, focusing on their interaction with α1A-adrenoceptors (α1-AR) and phosphodiesterase 4 (PDE4). AutoDock Vina-1.2.5 and Glide (Schrödinger Suite) (2023-2) were used to calculate the binding affinities and determine the features of their interactions by the molecular docking method; PlayMolecule software was used to perform molecular dynamics. Propoxazepam exhibits moderate free binding energy for α1A-adrenoceptors, as indicated by its average molecular mechanics/generalized Born surface area (MMGBSA) and Glide Score values. Compared to propoxazepam, 3-hydroxypropoxazepam has enhanced predicted affinity values for the alpha 1A adrenergic receptor, primarily due to the hydroxyl group, which facilitates the formation of additional hydrogen bonds. Propoxazepam, along with its metabolite 3-hydroxypropoxazepam, demonstrates promising interactions with PDE4A, characterized by notably low predicted free binding energy MMGBSA and strong binding affinity computed via AutoDock Vina. Among other ligands, propoxazepam demonstrates the lowest MMGBSA value with PDE4A (phosphodiesterase 4A). The best predicted binding scores of interaction with phosphodiesterase 4 is observed for propoxazepam with PDE4B (phosphodiesterase 4B) -10.3 kcal/mol, according to AutoDock Vina. Propoxazepam and its derivative 3-hydroxypropoxazepam interact with the active sites of PDE4B and PDE4D (phosphodiesterase 4 B) via a “hydrophobic clamp”, a typical binding mode for PDE inhibitors, which relies on crucial hydrophobic interactions. Binding of propoxazepam and its metabolite 3-hydroxypropoxazepa to PDE4B reduces the fluctuations of M-pocket residues and supports the conclusion that ligand binding stabilizes the protein structure of PDE4B. The MMGBSA method predicts that propoxazepam and 3-hydroxypropoxazepam have the most favourable predicted binding energies with PDE4D (2FMO). Since 1,4-benzodiazepines bind to phosphodiesterase 4 similarly to its inhibitors, this may support the hypothesis that benzodiazepines may affect α1-AR by inhibiting PDE4. The study of the binding mechanisms of 1,4-benzodiazepines with phosphodiesterase 4 and alpha-1A adrenoceptors helps to expand the understanding of the analgesic and anti-inflammatory effect of benzodiazepines associated with these proteins, which can be taken into account in the development of new analgesic and anti-inflammatory agents.
Development of a mechanism for managing the level of investment in R&D of city-forming enterprises (by the example of the metallurgical industry)
Authors: Yessengaliyeva Saltanat , Tapalova Assel , Melekova Assel , Ibadildin Nurkhat , Kairliyeva Gaukhar , Serikbayev Serik , Nursapina Kanbibi 
Published: August 2024

The object of the study is investment in R&D of enterprises. The problem of developing a mechanism for managing the level of R&D investment at industrial enterprises has been solved. The results are obtained:
– gradation of R&D investment levels at enterprises based on the application of the beta coefficient calculation methodology adapted to the R&D sphere;
– distribution of city-forming enterprises of the metallurgical industry by R&D investment levels: high level – 27 % of surveyed enterprises, average – 18 %, low – 55 %, critical – 0 %;
– development of a matrix based on the comparison of the level of R&D investment and the level of sales volumes of the enterprise's products calculated according to one algorithm. For each cell of the matrix, management decisions of strategic nature are proposed to increase the level of R&D investment.
The results obtained are explained by the assumption of a linear relationship between the size of R&D investment of a particular enterprise over time and aggregate industry R&D investment (as a benchmark). The tendency of R&D investment growth in the industry, regularity of R&D investments of the surveyed enterprises were confirmed, time series of R&D investment both at the evaluated enterprise and in the industry as a whole were processed using trend smoothing.
The features of the obtained results lie in the application of comparable coefficients (investments in R&D), as well as in the application of the developed assessment in the management of the enterprise.
The practical significance of this study results is the possibility of applying the obtained conclusions and recommendations to increase the level of R&D investment of large industrial enterprises in the volume, scope and conditions corresponding to the developing economy