bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut microbiota and intestinal rehabilitation: a prospective childhood cohort longitudinal study of short bowel syndrome (the MIRACLS study): study protocol
Authors: Cleminson Jemma S , Thomas Julian , Stewart Christopher J , Campbell David , Gennery Andrew , Embleton Nicholas D , Köglmeier Jutta , Wong Theodoric , Spruce Marie , Berrington Janet E 
Published: August 2024

IntroductionShort bowel syndrome (SBS) is the predominant cause of paediatric intestinal failure. Although life-saving, parenteral nutrition (PN) is linked to complications and may impact quality of life (QoL). Most children will experience intestinal rehabilitation (IR), but the mechanisms underpinning this remain to be understood. SBS is characterised by abnormal microbiome patterns, which might serve as predictive indicators for IR. We aim to characterise the microbiome profiles of children with SBS during IR, concurrently exploring how parental perspectives of QoL relate to IR.Methods and analysisThis study will enrol a minimum of 20 paediatric patients with SBS (0–18 years). Clinical data and biological samples will be collected over a 2-year study period. We will apply 16S rRNA gene sequencing to analyse the microbiome from faecal and gut tissue samples, with additional shotgun metagenomic sequencing specifically on samples obtained around the time of IR. Gas chromatography with flame ionisation detection will profile faecal short-chain fatty acids. Plasma citrulline and urinary intestinal fatty acid binding proteins will be measured annually. We will explore microbiome–clinical covariate interactions. Furthermore, we plan to assess parental perspectives on QoL during PN and post-IR by inviting parents to complete the Paediatric Quality of Life questionnaire at recruitment and after the completion of IR.Ethics and disseminationEthical approval was obtained from the East Midlands—Nottingham 2 Research Ethics Committee (22/EM/0233; 28 November 2022). Recruitment began in February 2023. Outcomes of the study will be published in peer-reviewed scientific journals and presented at scientific meetings. A lay summary of the results will be made available to participants and the public.Trial registration numberISRCTN90620576.
Economic evaluation of GnRH-agonist long protocol and GnRH-antagonist protocol in IVT/ICSI among the Chinese population: using pharmacoeconomic models
Authors: Si Yuxin , Chen Chunlan , Tang Yalan , Zhang Min , Tang Junying , Pu Kexue 
Published: August 2024

ObjectiveThis paper uses health economics methods to discuss the cost-effectiveness value of long protocol and antagonist protocol for in vitro fertilisation and embryo transfer (ET) in the Chinese population.DesignHealth economic evaluation study.SettingThe data needed to construct the model for this study were derived from published studies and other secondary sources in China.ParticipantsNo patients participated in the study.MeasuresThe main outcomes were live birth rate (LBR) and cost. From the societal perspective, we considered the direct and indirect costs over the course of the treatment cycles. A cost-effectiveness was measured using the incremental cost-effectiveness ratio and the probability that a protocol has higher net monetary benefit. Sensitivity analysis was carried out to verify the reliability of the simulation results.ResultsFor the Chinese population, the long protocol resulted in a higher LBR than the antagonist protocol (29.33% vs 20.39%), but at the same time, it was more expensive (￥29 146.26 (US$4333.17) vs ￥23 343.70 (US$3470.51)), in the case of considering only one fresh ET cycle. It was the same when considering subsequent frozen ET (FET) cycles (51.78% vs 42.81%; ￥30 703.02 (US$4564.62) vs ￥24 740.95 (US$3678.24)). The results of most subgroups were consistent with the results of the basic analysis. However, for certain populations, the long protocol was the inferior protocol (less effective and more expensive).ConclusionFor the Chinese population, when the monetary value per live birth was greater than ￥65 420 (US$9726) and ￥66 400 (US$9872), respectively, considering only one fresh cycle and considering subsequent frozen cycles, the long protocol is the preferred protocol. This threshold also varies for women of different ages and ovarian response capacities. For women in POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) group 2, group 3 and group 4, antagonist protocol is recommended as the preferred protocol. The results of this study need to be verified by further large-scale randomised controlled trials.
Prioritising nurses’ and doctors’ health at work: a scoping review of monitoring instruments
Authors: Boskma Amber , Braak Kim van der , Demenaga Kiki , Idema Demy , Hooft Lotty , Wietasch Götz , Franx Arie , van der Laan Maarten J 
Published: August 2024

ObjectiveNurses’ and doctors’ health at work is crucial for their overall performance and the quality of care they provide. The Jobs Demands Resources (JD-R) model offers a framework for health at work, encompassing ‘job demands’, ‘job resources’, ‘personal resources’, ‘leadership’, ‘well-being’ and ‘outcomes’. While various instruments exist to measure health, an overview of instruments specifically designed for assessing nurses and doctors health is currently missing. This study provides a comprehensive overview of available health instruments specifically developed and validated for healthcare professionals in hospital care.DesignScoping review.Data sourcesMEDLINE, Embase and CINAHL.Eligibility criteriaStudies assessing the health of nurses and/or doctors in hospitals using or evaluating instruments based on the JD-R model, published between January 2011 and January 2024, excluding student-exclusive samples.Data extraction and synthesisWe extracted data on study and sample characteristics, as well as details of the measurement instruments, including main and subconstructs. Instruments were categorised based on the JD-R model domains. Descriptive analysis and data visualisation were performed using Excel and Python.ResultsWe included 1204 studies, reporting 986 unique instruments. We identified 32 comprehensive instruments suitable for broad health screening, measuring four or more of the JD-R model domains. Additionally, we identified instruments focusing on specific domains for targeted screening needs. Furthermore, we present frequently reported instruments assumed to be extensively evaluated, user-friendly, accessible and available in multiple languages.ConclusionsHealth at work cannot be determined by a single instrument alone, underscoring the multidimensional nature of workplace health. Alternatively, organisations should select instruments based on domains most relevant and applicable to their context. This approach ensures a more comprehensive assessment of health at work.
Accuracy of two-dimensional transverse wave elastography of salivary glands in diagnosis of Sjögren’s disease: a systematic review and meta-analysis
Authors: Liu Jie , Xia Guangsha , Dai Zhaoqiu , Wang Ruirui , Feng Zhe , Ma Guquan , Zeng Liang , He Xiaojin 
Published: August 2024

ObjectivesTwo-dimensional shear wave elastography (2D-SWE) is a non-invasive technique for the evaluation of Sjögren’s disease (SjD). This study investigated the diagnostic accuracy of 2D-SWE in assessing major salivary gland involvement in SjD.DesignA systematic review and meta-analysis.Data sourcesData were obtained by searching PubMed, MEDLINE, EMBASE, Scopus, Cochrane library and CNKI from 1999 to 26 September 2022, which includes randomised clinical trial of 2D-SWE for the diagnosis of SjD.Eligibility criteria(1) Patients (≥18 years old) diagnosed with SjD following the international classification in 2002 or 2016 American College of Rheumatology-European League Against Rheumatism classification criteria for SjD; (2) The purpose of this study was to evaluate the diagnostic value of 2D-SWE in SjD; (3) The evaluation parameters for the diagnosis of SjD can be extracted or indirectly obtained in this article, including sensitivity, specificity, true positive, false positive, false negative, true negative, diagnostic point (Young’s modulus) and other data.Data extraction and synthesisFour authors independently screened and assessed the literature and extracted the data. RevMan V.5.3 and StataMP V.18 software were used for quality assessment and meta-analysis.ResultsWe included 8 studies with a total of 912 cases, including 509 patients with SjD. The high-risk bias in the quality evaluation focused on patient selection and index test. The pooled sensitivity, specificity and summary area under the curve of 2D-SWE were 0.75 (95% CI 0.62 to 0.84), 0.89 (95% CI 0.80 to 0.94) and 0.90 (95% CI 0.87 to 0.92), respectively.Conclusions2D-SWE has an acceptable diagnostic accuracy for SjD patients and is an effective tool for auxiliary diagnosis of SjD.PROSPERO registration numberCRD42022365766.
New triple therapy for the diagnosis of CKD-MBD: a cross-sectional study in Shanxi province
Authors: Zhao Zhi , Gao Yuanyuan , Sui WenDong , Zhang ZiTong , Feng Li , Wang Zhi , Yang Daihe , Zhou Yun , Li Rongshan , Huang Bo 
Published: August 2024

ObjectivesTo seek a triple combination of biomarkers for early diagnosis of chronic kidney disease-mineral and bone metabolic disorder and to explore the diagnostic efficacy of β2-microglobulin, parathyroid hormone and blood urea nitrogen in chronic kidney disease-mineral and bone metabolic disorder.ParticipantsWe collected medical records of 864 patients with chronic kidney disease (without direct contact with patients) and divided them into two groups based on the renal bone disease manifestations of all patients.Primary and secondary outcome measuresThere were 148 and 716 subjects in the Chronic kidney disease-mineral and bone metabolic disorder and the control groups, respectively. The aggregated data included basic information and various clinical laboratory indicators, such as blood lipid profile, antibody and electrolyte levels, along with renal function-related indicators.ResultsIt was observed that most renal osteopathy occurs in the later stages of chronic kidney disease. In the comparison of two clinical laboratory indicators, 16 factors were selected for curve analysis and compared. We discovered that factors with high diagnostic values were β2-microglobulin, parathyroid hormone and blood urea nitrogen.ConclusionsThe triple combination of β2-microglobulin+parathyroid hormone+blood urea nitrogen indicators can play the crucial role of a sensitive indicator for the early diagnosis of chronic kidney disease-mineral and bone metabolic disorder and in preventing or delaying the progress of chronic kidney disease-mineral and bone metabolic disorder.
Depressive and anxiety symptoms in caregivers of children with congenital ectopia lentis: a prospective cross-sectional study
Authors: Liang Xiaolin , Zhang Xinyu , Young Charlotte Aimee , Ma Yiyuan , Ye Qian , Zheng Danying , Jin Guangming 
Published: August 2024

ObjectivesTo evaluate the frequency and severity of depressive and anxiety symptoms and explore possible risk factors among caregivers of children with congenital ectopia lentis (CEL).DesignA prospective cross-sectional study was conducted.Participants108 patients and 108 informal caregivers (mainly parents) were included. Participants were grouped based on whether patients had systemic abnormalities: group 1 were children without systemic abnormalities and group 2 were children with systemic abnormalities.Outcome measuresThe 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder Scale (GAD-7) were used to assess depressive and anxiety symptoms, respectively.ResultsMore than half of caregivers (51.9%) have depressive or anxiety symptoms of some degree. 38.0% of caregivers suffered from both depressive and anxiety symptoms. 19.4% of caregivers had moderate to severe depressive symptoms (PHQ-9 score ≥10) while 16.7% reported moderate to severe anxiety symptoms (GAD-7 score ≥10). Between the two groups, the mean PHQ-9 and GAD-7 scores significantly differed (p=0.026 in PHQ-9; p=0.018 in GAD-7). The proportion of caregivers with moderate to severe symptoms was greater in group 2 than in group 1. In addition, there was a significant positive correlation between PHQ-9 and GAD-7 scores (r=0.827; p<0.001). Furthermore, best corrected visual acuity in the better eye of patients was positively correlated with both the PHQ-9 and GAD-7 scores (r=0.314, p<0.05 in PHQ-9; r=0.325, p<0.05 in GAD-7).ConclusionsDepressive and anxiety symptoms were common in caregivers of children with CEL, especially among those whose children had other systemic disease manifestations or low vision. This study illustrates the importance of depressive and anxiety symptom screening for these caregivers to implement effective psychological interventions and support strategies.
Efficacy of Qigong Baduanjin on nutritional status and quality of life in patients on haemodialysis: study protocol for a prospective randomised controlled trial
Authors: Zhou Jiayue , Hu Shouci , Zhang Xiang , Xia Cong , Wan Songyan , Yang Xiuyan , Yu Yajuan , Chen Han , Chen Hongbo 
Published: August 2024

IntroductionHaemodialysis (HD) patients usually engage in a low level of physical activities, which could impact the prognosis and mortality of this group. Fitness Qigong Baduanjin, a physical exercise from traditional Chinese Medicine, is known to have benefit in chronic heart failure patients and peritoneal dialysis patients. However, researches about Baduanjin in HD patients are currently limited. So, the aim of the study is to investigate the current exercise intensity of HD patients and its influencing factors, and to explore the effects of Baduanjin on HD patients.Methods and analysisThis prospective, non-blinded, randomised controlled trial will enrol patients with end-stage kidney disease who were stable on HD for more than 3 months. All eligible participants will be randomly divided into the intervention group undergoing Baduanjin and the control group without Baduanjin in a 1:1 ratio. The intervention group is required to perform Baduanjin two times per day, starting 30 min after breakfast and dinner, 45 min per session for a total of a 6 month, starting from 10 June 2024. Information such as laboratory biochemical examination indicators, radiological examination results and related scales and questionnaires will be collected at baseline, 1 month follow-up, 3 month follow-up and 6 month follow-up. All statistical tests are conducted through the two-tailed test, and a p-value≤0.05 will be considered statistically significant for the difference being tested. The description of quantitative indicators will be used in calculating the number of cases, mean, SD, median and IQR method. The classification indicators will be used to describe the number of cases and percentages (frequency and frequency rate).Ethics and disseminationThe study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Zhejiang Chinese Medical University (V20230521). The results will be reported in a peer-reviewed journal and a relevant academic conference.Trail registrationChiCTR2300074659.
Cohort profile: the CARTaGENE Cohort Nutrition Study (Quebec, Canada)
Authors: Ho Vikki , Csizmadi Ilona , Boucher Beatrice A , McInerney Maria , Boileau Catherine , Noisel Nolwenn , Payette Yves , Awadalla Philip , Koushik Anita 
Published: August 2024

PurposeTo address emerging nutritional epidemiological research questions, data from contemporary cohorts are needed. CARTaGENE is the largest ongoing prospective cohort study of men and women in Québec, Canada. Dietary information was collected making it a rich resource for the exploration of diet in the aetiology of many health outcomes.ParticipantsCARTaGENE recruited over 43 000 men and women aged 40–69 in two phases (A and B). In phase A, a total of 19 784 men and women were enrolled between 2009 and 2010. In 2011–2012, phase A participants of CARTaGENE were recontacted and invited to complete the self-administered Canadian Diet History Questionnaire II, which assessed usual intake over the past 12 months of a comprehensive array of foods, beverages and supplements; 9379 participants with non-missing age and sex data and with plausible total energy intake comprise the CARTaGENE Cohort Nutrition Study (4212 men; 5167 women).Findings to dateAvailable dietary data include intake of total energy, macronutrients and micronutrients, food group equivalents and a measure of diet quality based on the Canadian Healthy Eating Index 2005 (C-HEI 2005). Intake and diet quality varied among participants though they generally met the recommended dietary reference intakes for most nutrients. The mean C-HEI 2005 score was 61.5 (SD=14.0; max score=100), comparable to the general Canadian population. The mean (SD) scores for men and women separately were 57.0 (14.1) and 65.2 (12.8), respectively. C-HEI scores were higher for never smokers (61.6), those who had attained more than a high school education (61.4) and those with high physical activity (60.4) compared with current smokers (55.8), less than high school education level (56.2) and low physical activity (57.6), respectively (p values<0.01).Future plansThe CARTaGENE Cohort Nutrition Study is an additional resource of the CARTaGENE platform and is available internationally to examine research questions related to diet and health among contemporary populations. Starting in 2024, annual diet assessments using two 24-hour dietary recalls over a 30-day period will take place, further expanding the cohort as a resource for dietary research.
Wider health needs in attention deficit hyperactivity disorder from lived and professional experience: a qualitative framework analysis
Authors: Ward John , McBride Audrey , Gudka Rebecca , Becker Kieran , Newlove-Delgado Tamsin , Price Anna 
Published: August 2024

ObjectivesThis study aimed to explore the perspectives of people with attention deficit hyperactivity disorder (ADHD), their supporters and primary care professionals (PCPs), on the wider physical and mental health needs of people with ADHD and the support currently available.DesignQualitative semi-structured interviews, analysed using reflexive thematic analysis.SettingFive general practice surgeries across England.ParticipantsParticipants with lived experience (people with ADHD and their supporters (n=11)) and PCPs (n=9) (eg, general practitioners and practice managers), recruited via clinical academic networks and previous work packages of this study.ResultsWe generated three major themes in relation to ADHD, using reflexive thematic analysis: understanding health, barriers to health and addressing health. Within these, participants reflected on mental and physical health challenges, as well as wider social difficulties and variability in support offered/accessed.ConclusionsThis study highlights that health problems in ADHD are complex and rooted both in individual factors (eg, mental health) and social factors (eg, support). This study also highlights the differences in expectations and fulfilment of healthcare.
Deprescribing benzodiazepine receptor agonists in older adults: a mixed-methods study to adapt the Canadian D-PRESCRIBE intervention to the Belgian community setting
Authors: Pétein Catherine , Dujardin Nathalie , de Montigny Manon , Dewez Evelyne , Spinewine Anne , Henrard Séverine 
Published: August 2024

ObjectiveGuidelines recommend deprescribing benzodiazepine receptor agonists (BZRA) in older adults, yet implementation in clinical practice remains limited. Adapting effective, evidence-based interventions to a new context is a resource-saving strategy. In Canada, the D-PRESCRIBE intervention comprised a patient educational brochure and a pharmaceutical opinion inviting physicians to revise BZRA prescribing and consider safer alternatives. Due to its effectiveness on BZRA deprescribing among Canadian older adults, we aimed to adapt the D-PRESCRIBE intervention to the Belgian community setting.DesignRecommendations from the ADAPT guidance, that provides a systematic approach for adapting interventions to new contexts, were followed. We conducted a mixed-methods study that comprised (1) group discussions and cognitive interviews to assess the acceptability and need for adaptation of the intervention’s components and (2) a survey on the adapted pharmaceutical opinion. A research committee involving stakeholders’ representatives decided on the adaptations, respecting the core functions of both tools. Changes in intervention components were reported following the Model for Adaptation Design and Impact framework.SettingBelgian French-speaking community setting.ParticipantsSix older adults (≥65 years), six general practitioners (GPs) and seven pharmacists participated in the group discussions or interviews. 46 GPs and 91 pharmacists responded to the survey.ResultsParticipants welcomed the brochure positively. Still, some changes in the vocabulary, wording, photos and icons were made for several purposes including making the patient feel concerned about the brochure and softening the use of fear. The pharmaceutical opinion aroused mixed perceptions. Its name, layout and content were adapted to enhance its acceptability and fit with our healthcare system, practices and national guidelines. The survey highlighted several enablers and barriers to its use from the perspectives of GP and pharmacist.ConclusionsThe Canadian D-PRESCRIBE intervention was adapted to the Belgian setting following a thorough and transparent process. Its feasibility will be tested in a future pilot study (NCT:05929417).
Patients’ preferences, experiences and expectations with wait time until surgery in gynaecological oncology: a mixed-methods study in two gynaecological oncological centres in the Netherlands
Authors: van den Berg Kim , Knegt Anne , Fons Guus , Lok Christianne A R , Aarts Johanna W M 
Published: August 2024

ObjectivesPatient-centredness of care during wait time before surgery can be improved. In this study we aimed to assess (1) patients’ experiences with and preferences regarding wait time before surgery; (2) the impact of wait time on quality of life (QoL) and (3) which factors influence patients’ wait time experience.Design, setting, participantsWe performed an exploratory sequential mixed-methods study among women with gynaecological cancer in two tertiary hospitals. We conducted semistructured interviews and identified aspects of QoL and factors that influenced wait time acceptability through thematic analysis. We developed a questionnaire from this thematic analysis which was completed by 97 women. Descriptive statistics and univariate and multivariate regression analyses were performed.ResultsAverage ideal wait time was 3.5 weeks (±1.7 weeks), minimum and maximum acceptable wait times were 2.2 and 5.6 weeks. Many patients scored above the threshold of the Hospital Anxiety and Depression Scale for anxiety (48%) or depression (34%), had sleeping problems (56%) or experienced pain (54%). A number of factors were more common in patients who indicated that their wait time had been too long: low education level (OR 7.4, 95% CI 0.5 to 5.0, p=0.007), time to surgery >4 weeks (OR 7.0, 95% CI 0.8 to 4.4, p=0.002) and experienced sleep disturbance (OR 3.27, 95% CI 0.0 to 3.1, p=0.05). If patients expectation of wait time was >4 weeks (OR 0.20, 95% CI −4.0 to −0.5 p=0008) or if patients experienced pain (OR 0.26, 95% CI −3.6 to −0.3, p=0.03), they less frequently indicated that wait time had been too long.ConclusionTo improve patient-centredness of care, healthcare providers should aim to reduce wait time to 3–4 weeks and ensure that patients are well informed about the length of wait time and are aware of high levels of anxiety, depression and pain during this time. Future studies should evaluate what interventions can improve QoL during wait time.