bluuebunny/crossref_metadata_2025_split huggingface dataset:
Third-order resonant wave interactions under the influence of background current fields
Authors: Waseda Takuji , Kinoshita T. , Cavaleri L. , Toffoli A. 
Published: October 2015

A series of experiments were conducted in a wave basin (50 m long, 10 m wide and 5 m deep) generating two waves propagating at an angle by a directional wavemaker. When the two waves were selected from a resonant triplet, an initially non-existing wave grew as the waves propagated down the tank. The linear growth rate of the resonating wave agreed well with third-order resonance theory based on Zakharov’s reduced gravity equation. Additional experiments with opposing and coflowing mean current with large temporal and spatial variations were conducted. As the flow rate increased, the linear growth was suppressed. As reproduced numerically with Zakharov’s equation, the resonant interaction saturated at time scales inversely proportional to the magnitude of the forced random resonance detuning. It is conjectured that the resonance is detuned by the variation and not by the mean of the current field due to wavelength-dependent Doppler shift and to the refraction of wave rays. Further analysis of the spectral evolution revealed that while discrete peaks appear at high frequencies as a result of dynamical cascading, a continuously saturated spectrum develops in the background as the current speed increases. Additional experiments were conducted studying the evolution of the random directional wave on a dynamical time scale under the influence of current. Due to random resonance detuning by the current, the spectral tail tended to be suppressed.
Weyl Spectral Identity and Biquasitriangularity
Authors: Kubrusly C. S. , Duggal B. P. 
Published: October 2015

AbstractLet A and B be operators acting on infinite-dimensional complex Banach spaces. We say that the Weyl spectral identity holds for the tensor product A⊗B if σw(A⊗B) = σw(A)·σ(B)∪σ(A)·σw(B), where σ(·) and σw(·) stand for the spectrum and the Weyl spectrum, respectively. Conditions on A and B for which the Weyl spectral identity holds are investigated. Especially, it is shown that if A and B are biquasitriangular (in particular, if the spectra of A and B have empty interior), then the Weyl spectral identity holds. It is also proved that if A and B are biquasitriangular, then the tensor product A ⊗ B is biquasitriangular.
Turán-Type Inequalities for Some Lommel Functions of the First Kind
Authors: Baricz Árpád , Koumandos Stamatis 
Published: October 2015

AbstractIn this paper certain Turán-type inequalities for some Lommel functions of the first kind are deduced. The key tools in our proofs are the infinite product representation for these Lommel functions of the first kind, a classical result of Pólya on the zeros of some particular entire functions, and the connection of these Lommel functions with the so-called Laguerre–Pólya class of entire functions. Moreover, it is shown that in some cases Steinig's results on the sign of Lommel functions of the first kind combined with the so-called monotone form of l’Hospital's rule can be used in the proof of the corresponding Turán-type inequalities.
ALCOHOL PANIC, SOCIAL ENGINEERING, AND SOME REFLECTIONS ON THE MANAGEMENT OF WHITES IN EARLY APARTHEID SOCIETY, 1948–1960
Authors: ROOS NEIL 
Published: October 2015

AbstractThe connection between ideologies of nation, alcohol abuse, and social engineering have not received systematic attention from historians. This article offers a case-study from the history of apartheid South Africa. Working around a fragment of apartheid history, a bureaucratic panic that excessive white drinking threatened the stability of the racial order, it explores geneaologies of state responses to white drinking in South Africa. It then concentrates on the role of Geoffrey Cronje, an intellectual / bureaucrat who not only drove the panic but then used it to implement new forms of social engineering in white South African society. Drawing on penal and welfarist traditions as well as medical models of treatment, he introduced a system for the discipline and correction of whites who drank heavily that drew on both state and private resources. I examine how the defiance of those incarcerated for drinking helped shaped subsequent, lighter-handed responses that managed the drinking of greater numbers of whites. This article may provide avenues for investigating alcohol abuse, state intervention, and social engineering in a range of mid-twentieth-century societies.
CONSERVATISM, EDMUND BURKE, AND THE INVENTION OF A POLITICAL TRADITION, c. 1885–1914
Authors: JONES EMILY 
Published: October 2015

AbstractThis article addresses the reputation of Edmund Burke and his transformation into the ‘founder of modern conservatism’. It argues that this process occurred primarily between 1885 and 1914 in Britain. In doing so, this article challenges the existing orthodoxy which attributes this development to the work of Peter Stanlis, Russell Kirk, and other conservative American scholars. Moreover, this article historicizes one aspect of the construction of C/conservatism as both an intellectual (small-c) and political (capital-C) tradition. Indeed, though the late Victorian and Edwardian period saw the construction of political traditions of an entirely novel kind, the search for ‘New Conservatism’ has been neglected by comparison with New Liberalism. Thus, this study explores three main themes: the impact of British debates about Irish Home Rule on Burke's reputation and status; the academic systematization of Burke's work into a ‘political philosophy of conservatism’; and, finally, the appropriation of Burke by Conservative Unionists during the late Edwardian constitutional crisis. The result is to show that by 1914 Burke had been firmly established as a ‘conservative’ political thinker whose work was directly associated with British Conservatism.
DEBATING FEMALE MUSICAL PROFESSIONALISM AND ARTISTRY IN THE BRITISH PRESS, c. 1820–1850
Authors: KENNERLEY DAVID 
Published: October 2015

AbstractThe entrance of women into the male-dominated spheres of the professions and the arts has been a major theme of women's and gender history in nineteenth-century Britain. In general, historians have located this development primarily in the second half of the century and depicted it as an important corollary to the political aims of the wider women's movement. In contrast, this article contends that an overlooked earlier context for the formation and emergence of ideas of female professionalism and artistry were the debates surrounding female singers in the press between c. 1820 and 1850. In this era, writers in newly emerging specialist music periodicals increasingly advocated a view of female singers as both professionals and artists. Such views did not dominate discourse, however. There remained a great deal of ambivalence even in specialist publications about just how far female singers should pursue the lifestyle of the professional artist, while in the mainstream press very different attitudes towards female singers prevailed. Although female musical professionalism and artistry therefore remained contested concepts, this article highlights the significance of these debates about female singers as an important source for the new ideas about women's professional and artistic work emerging in nineteenth-century British society.
Histopathological evaluation of parotid gland neoplasms in Queensland, Australia
Authors: Coombe R F , Lam A K , O'Neill J 
Published: October 2015

AbstractBackground:Parotid gland tumours are complex neoplasms with a broad histological range. The parotid gland is also a common site of face and scalp skin cancer metastases.Method:Parotidectomies performed by ENT department in the Gold Coast health district from 2006 to 2013.Results:A total of 158 specimens were examined. Of these, 53.80 per cent were benign and 46.20 per cent were malignant. Pleomorphic adenoma was the most common tumour (29.11 per cent), followed by cutaneous squamous cell carcinoma (23.42 per cent) and Warthin's tumour (12.03 per cent).Conclusion:Metastatic squamous cell carcinoma accounted for a large proportion of parotid masses in our case series, reflecting the high prevalence of non-melanoma skin cancer in Australia. Primary parotid neoplasms had similar incidence rates to other studies.
Consistency in adult reporting of adverse childhood experiences
Authors: Colman I. , Kingsbury M. , Garad Y. , Zeng Y. , Naicker K. , Patten S. , Jones P. B. , Wild T. C. , Thompson A. H. 
Published: October 2015

BackgroundMany studies have used retrospective reports to assess the long-term consequences of early life stress. However, current individual characteristics and experiences may bias the recall of these reports. In particular, depressed mood may increase the likelihood of recall of negative experiences. The aim of the study was to assess whether specific factors are associated with consistency in the reporting of childhood adverse experiences.MethodThe sample comprised 7466 adults from Canada's National Population Health Survey who had reported on seven childhood adverse experiences in 1994/1995 and 2006/2007. Logistic regression was used to explore differences between those who consistently reported adverse experiences and those whose reports were inconsistent.ResultsAmong those retrospectively reporting on childhood traumatic experiences in 1994/1995 and 2006/2007, 39% were inconsistent in their reports of these experiences. The development of depression, increasing levels of psychological distress, as well as increasing work and chronic stress were associated with an increasing likelihood of reporting a childhood adverse experience in 2006/2007 that had not been previously reported. Increases in mastery were associated with reduced likelihood of new reporting of a childhood adverse experience in 2006/2007. The development of depression and increases in chronic stress and psychological distress were also associated with reduced likelihood of ‘forgetting’ a previously reported event.ConclusionsConcurrent mental health factors may influence the reporting of traumatic childhood experiences. Studies that use retrospective reporting to estimate associations between childhood adversity and adult outcomes associated with mental health may be biased.
Spirituality as an ethical challenge in Indian palliative care: A systematic review
Authors: Gielen Joris , Bhatnagar Sushma , Chaturvedi Santosh K. 
Published: October 2015

AbstractObjective:Spiritual care is recognized as an essential component of palliative care (PC). However, patients' experience of spirituality is heavily context dependent. In addition, Western definitions and findings regarding spirituality may not be applicable to patients of non-Western origin, such as Indian PC patients. Given the particular sociocultural, religious, and economic conditions in which PC programs in India operate, we decided to undertake a systematic review of the literature on spirituality among Indian PC patients. We intended to assess how spirituality has been interpreted and operationalized in studies of this population, to determine which dimensions of spirituality are important for patients, and to analyze its ethical implications.Method:In January of 2015, we searched five databases (ATLA, CINAHL, EMBASE, PsycINFO, and PubMed) using a combination of controlled and noncontrolled vocabulary. A content analysis of all selected reports was undertaken to assess the interpretation and dimensions of spirituality. Data extraction from empirical studies was done using a data-extraction sheet.Results:A total of 39 empirical studies (12 qualitative, 21 quantitative, and 6 mixed-methods) and 18 others (10 reviews, 4 opinion articles, and 4 case studies) were retrieved. To date, no systematic review on spirituality in Indian PC has been published. Spirituality was the main focus of only six empirical studies. The content analysis revealed three dimensions of spirituality: (1) the relational dimension, (2) the existential dimension, and (3) the values dimension. Religion is prominent in all these dimensions. Patients' experiences of spirituality are determined by the specifically Indian context, which leads to particular ethical issues.Significance of results:Since spiritual well-being greatly impacts quality of life, and because of the substantial presence of people of Indian origin living outside the subcontinent, the findings of our review have international relevance. Moreover, our review illustrates that spirituality can be an ethical challenge and that more ethical reflection on provision of spiritual care is needed.
Entwicklung eines Inventars für Job-Coping und -Rückkehrintention (JoCoRi)
Authors: Muschalla Beate , Fay Doris , Hoffmann Karin 
Published: October 2015

Zusammenfassung. Ein großer Anteil der Erwerbstätigen ist aufgrund gesundheitlicher Einschränkungen einmalig oder mehrfach in seiner Berufsbiografie längere Zeit arbeitsunfähig. Auf Grundlage etablierter psychologischer Konstrukte und empirischer Befunde wurde ein spezifisch arbeitsbezogenes Inventar für Job-Coping und Rückkehrintention (JoCoRi) entwickelt. Der Selbsteinschätzungsfragebogen wurde an drei unabhängigen Stichproben (N = 243, N = 337, N = 111) von Rehabilitationspatienten aus Psychosomatik, Orthopädie, Kardiologie und Neurologie geprüft. Faktorenanalytische Ergebnisse der ersten Stichprobe bestätigen eine mehrfaktorielle Struktur. Das Inventar enthält 30 Items in 7 Skalen: 1. Arbeitsbezogene Rückkehrintention und -planung, 2. Arbeitsbezogene Selbstwirksamkeitserwartung, 3. Arbeitsbezogene Selbstberuhigung und Selbstinstruktion, 4. Arbeitsbezogene externale Kontrollüberzeugung, 5. Aktives Coping am Arbeitsplatz, 6. Bedeutung der Arbeit, 7. Kontrollüberzeugung bzgl. der Arbeitsaufnahme. Die Varianzaufklärung liegt bei 68 %. 25 Items haben Hauptladungen > .60. Interne Konsistenzen und Trennschärfen sind überwiegend zufriedenstellend. Die Modellgüte der konfirmatorischen Faktorenanalyse ist überzeugend. Das Modell ist in einer unabhängigen Stichprobe stabil (N = 337). Die Skalen wurden mit inhaltlich analogen Globalkonstrukten validiert. Die mehrfaktorielle Struktur kann in der zweiten Stichprobe repliziert werden. Eine längsschnittliche Analyse der dritten Stichprobe prüft die prädiktive Validität der Rückkehrintentionsskala; sie wird hinsichtlich Arbeitsunfähigkeitsdauer und Arbeitsfähigkeitsstatus bestätigt.
P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
Authors: Shamseddine A A , Clarke C J , Carroll B , Airola M V , Mohammed S , Rella A , Obeid L M , Hannun Y A 
Published: October 2015

AbstractNeutral sphingomyelinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. Although previous studies have reported transcriptional upregulation of nSMase2 in response to daunorubicin, through Sp1 and Sp3 transcription factors, the role of the DNA damage pathway in regulating nSMase2 remains unclear. In this study, we show that doxorubicin induces a dose-dependent induction of nSMase2 mRNA and protein with concomitant increases in nSMase activity and ceramide levels. Upregulation of nSMase2 was dependent on ATR, Chk1 and p53, thus placing it downstream of the DNA damage pathway. Moreover, overexpression of p53 was sufficient to transcriptionally induce nSMase2, without the need for DNA damage. DNA-binding mutants as well as acetylation mutants of p53 were unable to induce nSMase2, suggesting a role of nSMase2 in growth arrest. Moreover, knockdown of nSMase2 prevented doxorubicin-induced growth arrest. Finally, p53-induced nSMase2 upregulation appears to occur via a novel transcription start site upstream of exon 3. These results identify nSMase2 as a novel p53 target gene, regulated by the DNA damage pathway to induce cell growth arrest.
K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells
Authors: Yaron J R , Gangaraju S , Rao M Y , Kong X , Zhang L , Su F , Tian Y , Glenn H L , Meldrum D R 
Published: October 2015

AbstractP2X7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in LPS-primed macrophages. The role of potassium and calcium in inflammasome regulation is not well understood, largely due to limitations in existing methods for interrogating potassium in real time. The use of KS6, a novel sensor for selective and sensitive dynamic visualization of intracellular potassium flux in live cells, multiplexed with the intracellular calcium sensor Fluo-4, revealed a coordinated relationship between potassium and calcium. Interestingly, the mitochondrial potassium pool was mobilized in a P2X7 signaling, and ATP dose-dependent manner, suggesting a role for mitochondrial sensing of cytosolic ion perturbation. Through treatment with extracellular potassium we found that potassium efflux was necessary to permit sustained calcium entry, but not transient calcium flux from intracellular stores. Further, intracellular calcium chelation with BAPTA-AM indicated that P2X7-induced potassium depletion was independent of calcium mobilization. This evidence suggests that both potassium efflux and calcium influx are necessary for mitochondrial reactive oxygen generation upstream of NLRP3 inflammasome assembly and pyroptotic cell death. We propose a model wherein potassium efflux is necessary for calcium influx, resulting in mitochondrial reactive oxygen generation to trigger the NLRP3 inflammasome.
DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis
Authors: Zhou J , Ning Z , Wang B , Yun E-J , Zhang T , Pong R-C , Fazli L , Gleave M , Zeng J , Fan J , Wang X , Li L , Hsieh J-T , He D , Wu K 
Published: October 2015

AbstractLoss of DAB2IP, a novel tumor suppressor gene, is associated with the high risk of aggressive prostate cancer (PCa). Previously, we reported that DAB2IP modulated androgen receptor activation in the development of castration-resistant PCa; however, its direct action on the failure of androgen deprivation therapy (ADT) remains largely unknown. In this study, we showed that DAB2IP knockdown could significantly enhance in vitro growth and colony formation of PCa cells following ADT as well as tumorigenicity in pre-castrated nude mice. In addition, DAB2IP loss stabilized mitochondrial transmembrane potential, prevented release of cytochrome c, Omi/HtrA2 and Smac from the mitochondria to the cytoplasm and inhibited intrinsic apoptosis induced by ADT. Mechanistically, DAB2IP could interact with the signal transducer and activator of transcription 3 (STAT3) via its unique PR domain and suppress STAT3 phosphorylation and transactivation, leading to the inhibition of survivin expression in PCa cells. Moreover, the luminal epithelia in DAB2IP−/− mice with more activated STAT3 and survivin expression were resistant to castration-induced apoptosis. Consistently, DAB2IP expression inversely correlated with STAT3 phosphorylation and survivin expression in PCa patients. Together, our data indicate that DAB2IP loss reprograms intracellular signal transduction and anti-apoptotic gene expression, which potentiates PCa cell survival from ADT-induced cell death.
A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells
Authors: Mughal W , Nguyen L , Pustylnik S , da Silva Rosa S C , Piotrowski S , Chapman D , Du M , Alli N S , Grigull J , Halayko A J , Aliani M , Topham M K , Epand R M , Hatch G M , Pereira T J , Kereliuk S , McDermott J C , Rampitsch C , Dolinsky V W , Gordon J W 
Published: October 2015

AbstractExposure to metabolic disease during fetal development alters cellular differentiation and perturbs metabolic homeostasis, but the underlying molecular regulators of this phenomenon in muscle cells are not completely understood. To address this, we undertook a computational approach to identify cooperating partners of the myocyte enhancer factor-2 (MEF2) family of transcription factors, known regulators of muscle differentiation and metabolic function. We demonstrate that MEF2 and the serum response factor (SRF) collaboratively regulate the expression of numerous muscle-specific genes, including microRNA-133a (miR-133a). Using tandem mass spectrometry techniques, we identify a conserved phosphorylation motif within the MEF2 and SRF Mcm1 Agamous Deficiens SRF (MADS)-box that regulates miR-133a expression and mitochondrial function in response to a lipotoxic signal. Furthermore, reconstitution of MEF2 function by expression of a neutralizing mutation in this identified phosphorylation motif restores miR-133a expression and mitochondrial membrane potential during lipotoxicity. Mechanistically, we demonstrate that miR-133a regulates mitochondrial function through translational inhibition of a mitophagy and cell death modulating protein, called Nix. Finally, we show that rodents exposed to gestational diabetes during fetal development display muscle diacylglycerol accumulation, concurrent with insulin resistance, reduced miR-133a, and elevated Nix expression, as young adult rats. Given the diverse roles of miR-133a and Nix in regulating mitochondrial function, and proliferation in certain cancers, dysregulation of this genetic pathway may have broad implications involving insulin resistance, cardiovascular disease, and cancer biology.
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development
Authors: Giraddi Rajshekhar R. , Shehata Mona , Gallardo Mercedes , Blasco Maria A. , Simons Benjamin D. , Stingl John 
Published: October 2015

AbstractThe cycling properties of mammary stem and progenitor cells is not well understood. To determine the division properties of these cells, we administered synthetic nucleosides for varying periods of time to mice at different stages of postnatal development and monitored the rate of uptake of these nucleosides in the different mammary cell compartments. Here we show that most cell division in the adult virgin gland is restricted to the oestrogen receptor-expressing luminal cell lineage. Our data also demonstrate that the oestrogen receptor-expressing, milk and basal cell subpopulations have telomere lengths and cell division kinetics that are not compatible with these cells being hierarchically organized; instead, our data indicate that in the adult homeostatic gland, each cell type is largely maintained by its own restricted progenitors. We also observe that transplantable stem cells are largely quiescent during oestrus, but are cycling during dioestrus when progesterone levels are high.