bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chiral recognition for the complexation dynamics of β-cyclodextrin with the enantiomers of 2-naphthyl-1-ethanol
Authors: Tang Hao , Sutherland Andria S. M. , Osusky Lana M. , Li Yan , Holzwarth Josef F. , Bohne Cornelia 
Published: December 2013

AbstractThe focus of this study is to understand the origin of the chiral recognition for a host–guest system containing complexes with different stoichiometries. Each enantiomer of 2-naphthyl-1-ethanol forms two different 1:1 complexes with β-cyclodextrin, leading to the formation of three different 2:2 complexes. One of these 2:2 complexes leads to excimer emission of the guest. Fluorescence studies were employed to determine the binding isotherms for the 1:1 and 2:2 complexes. No chiral discrimination was directly observed for the formation of the 1:1 complexes, while higher equilibrium constants (29% from binding isotherms and 40% from kinetic studies) were observed for the formation of the 2:2 complexes with (R)-2-naphthyl-1-ethanol when compared to the formation of the 2:2 complexes formed from (S)-2-naphthyl-1-ethanol. The relaxation kinetics was studied using stopped-flow experiments. The formation of the 2:2 complexes was followed by detecting the excimer emission from one of the 2:2 complexes. The relaxation kinetics was faster for (S)-2-naphthyl-1-ethanol, where a higher dissociation rate constant, by 47%, was observed, suggesting that the chiral discrimination occurs because the interaction between two cyclodextrins is more favorable for the complexes containing (R)-2-naphthyl-1-ethanol when compared to (S)-2-naphthyl-1-ethanol. The same overall equilibrium constants were observed for the 1:1 complexes with both enantiomers showing that at a given cyclodextrin concentration the sum of the two types of 1:1 complexes is the same for both enantiomers. However, analysis of the binding isotherms indicates that the ratio between the two different 1:1 complexes for each enantiomer was different for (R)- and (S)-2-naphthyl-1-ethanol.
Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications
Authors: Patel Vaibhav B. , Parajuli Nirmal , Oudit Gavin Y. 
Published: December 2013

Diabetes mellitus results in severe cardiovascular complications, and heart disease and failure remain the major causes of death in patients with diabetes. Given the increasing global tide of obesity and diabetes, the clinical burden of diabetes-induced cardiovascular disease is reaching epidemic proportions. Therefore urgent actions are needed to stem the tide of diabetes which entails new prevention and treatment tools. Clinical and pharmacological studies have demonstrated that AngII (angiotensin II), the major effector peptide of the RAS (renin–angiotensin system), is a critical promoter of insulin resistance and diabetes mellitus. The role of RAS and AngII has been implicated in the progression of diabetic cardiovascular complications and AT1R (AngII type 1 receptor) blockers and ACE (angiotensin-converting enzyme) inhibitors have shown clinical benefits. ACE2, the recently discovered homologue of ACE, is a monocarboxypeptidase which converts AngII into Ang-(1–7) [angiotensin-(1–7)] which, by virtue of its actions on the MasR (Mas receptor), opposes the effects of AngII. In animal models of diabetes, an early increase in ACE2 expression and activity occurs, whereas ACE2 mRNA and protein levels have been found to decrease in older STZ (streptozotocin)-induced diabetic rats. Using the Akita mouse model of Type 1 diabetes, we have recently shown that loss of ACE2 disrupts the balance of the RAS in a diabetic state and leads to AngII/AT1R-dependent systolic dysfunction and impaired vascular function. In the present review, we will discuss the role of the RAS in the pathophysiology and treatment of diabetes and its complications with particular emphasis on potential benefits of the ACE2/Ang-(1–7)/MasR axis activation.
Zipping, entanglement, and the elastic modulus of aligned single-walled carbon nanotube films
Authors: Won Yoonjin , Gao Yuan , Panzer Matthew A. , Xiang Rong , Maruyama Shigeo , Kenny Thomas W. , Cai Wei , Goodson Kenneth E. 
Published: December 2013

Significance
Aligned carbon nanotube films promise the unusual combination of high thermal conductivity and mechanical compliance. Here, the mechanical compliance of single-walled nanotube films has been measured and linked to their morphology and microscopic motions, including zipping, unzipping, and entanglement. The physical mechanisms governing the mechanical response include bending forces or van der Waals interactions, with the dominant mechanism depending on the nanotube density and alignment. The dependence of film morphology on mechanical modulus explored here provides the foundation for modeling of a variety of other properties including thermal and electrical conductivity.
A Reassessment of Virulence Phenotypes of Soybean Cyst Nematode (Heterodera glycines) in China with HG Typing Method
Authors: Wang D. , Zhu X. F. , Wang Y. Y. , Luo X. , Song P. , Zhu F. , Wang F. , Chen J. S. , Chen L. J. , Duan Y. X. 
Published: December 2013

Soybean cyst nematode, Heterodera glycines Ichinohe, is the most destructive pest of soybean (Glycine max) worldwide, including China. H. glycines virulence phenotypes can be described in two ways. One is the race determination test that uses four soybean lines to categorize H. glycines into 16 “races” (3). The HG type designation is similar, but avoids the implications of the term “race” and includes seven soybean lines rather than four (2). In China, previous data revealed the occurrence of nine H. glycines races including races 1 through 7, 9, and 14, whereas HG types have not been recorded (1). The objective of this study was to reassess virulence phenotypes of H. glycines in China by means of HG types. In 2011 and 2012, 10 SCN populations from the primary soybean production regions of China were identified as six races (races 1, 2, 3, 4, 5, 6, and 14) with the race test scheme (3) and were cultured on a H. glycines-susceptible soybean cultivar. In 2013, seven indicator soybean lines (PI 548402, PI 88788, PI 90763, PI 437654, PI 209332, PI 89772, and PI 548316) plus the susceptible standard soybean “Lee74” were used to determine the HG types of these populations following standardized procedures (2) with some modification in a growth chamber set at 28°C under 16-h days. After 30 days, females were extracted from roots and collected, and a female index was calculated for each indicator line (2,3). The average number of females on Lee74 was more than 100 in all the tests. Eight HG types were identified in the populations tested: HG type 0 (race 3), HG type 7 (race 3 or 6), HG type 2.7 (race 1 or 5), HG type 5.7 (race 3), HG type 1.3.7 (race 14), HG type 2.5.7 (race 1), HG type 1.2.5.7 (race 2), and HG type 1.2.3.5.7 (race 4). To our knowledge, this is the first report of H. glycines HG types in China, which will contribute to development of management strategies implementing the use of resistant cultivars. This work was supported by the Special Fund for Agro-scientific Research in the Public Interest 200903040-03 and the China Agriculture Research System CARS-04. References: (1) W. G. Lu et al. Agr. Sci. China 5:615, 2006. (2) T. L. Niblack et al. J. Nematol. 34:279, 2002. (3) R. D. Riggs and D. P. Schmitt. J. Nematol. 20:392, 1988.
Designer Psychostimulants in Urine by Liquid Chromatography–Tandem Mass Spectrometry,
Authors: Kerrigan Sarah , Mott Ashley , Jatzlau Breanna , Ortiz Francisco , Perrella Laura , Martin Sarah , Bryand Kelsie 
Published: December 2013

AbstractDesigner psychostimulants are known by recreational drug users to produce a complex array of adrenergic and hallucinogenic effects. Many of these drugs are not targeted during routine toxicology testing and as a consequence, they are rarely reported. The purpose of this study was to develop a procedure for the detection of 15 psychostimulants in urine using liquid chromatography–tandem mass spectrometry (LC‐MS/MS), specifically 2,5‐dimethoxy‐4‐bromophenethylamine (2C‐B), 2,5‐dimethoxy‐4‐chlorophenethylamine (2C‐C), 2,5‐dimethoxy‐4‐methylphenethylamine (2C‐D), 2,5‐dimethoxy‐4‐ethylphenethylamine (2C‐E), 2,5‐dimethoxyphenethylamine (2C‐H), 2,5‐dimethoxy‐4‐iodophenethylamine (2C‐I), 2,5‐dimethoxy‐4‐ethylthiophenethylamine (2C‐T‐2), 2,5‐dimethoxy‐4‐isopropylthiophenethylamine (2C‐T‐4), 2,5‐dimethoxy‐4‐propylthiophenethylamine (2C‐T‐7), 2,5‐dimethoxy‐4‐bromoamphetamine (DOB), 2,5‐dimethoxy‐4‐chloroamphetamine (DOC), 2,5‐dimethoxy‐4‐ethylamphetamine (DOET), 2,5‐dimethoxy‐4‐iodoamphetamine (DOI), 2,5‐dimethoxy‐4‐methylamphetamine (DOM), and 4‐methylthioamphetamine (4‐MTA). Analytical recoveries using solid‐phase extraction were 64–92% and the limit of detection was 0.5 ng/mL for all drugs except 2C‐B (1 ng/mL). The assay was evaluated in terms of analytical recovery, precision, accuracy, linearity, matrix effect, and interferences. The technique allows for the simultaneous detection of 15 psychostimulants at sub‐ng/mL concentrations.
Morphometric Comparison of Clavicle Outlines from 3D Bone Scans and 2D Chest Radiographs: A Shortlisting Tool to Assist Radiographic Identification of Human Skeletons
Authors: Stephan Carl N. , Amidan Brett , Trease Harold , Guyomarc'h Pierre , Pulsipher Trenton , Byrd John E. 
Published: December 2013

AbstractThis paper describes a computerized clavicle identification system primarily designed to resolve the identities of unaccounted‐for U.S. soldiers who fought in the Korean War. Elliptical Fourier analysis is used to quantify the clavicle outline shape from skeletons and postero‐anterior antemortem chest radiographs to rank individuals in terms of metric distance. Similar to leading fingerprint identification systems, shortlists of the top matching candidates are extracted for subsequent human visual assessment. Two independent tests of the computerized system using 17 field‐recovered skeletons and 409 chest radiographs demonstrate that true‐positive matches are captured within the top 5% of the sample 75% of the time. These results are outstanding given the eroded state of some field‐recovered skeletons and the faintness of the 1950's photofluorographs. These methods enhance the capability to resolve several hundred cold cases for which little circumstantial information exists and current DNA and dental record technologies cannot be applied.
Quantification of Perspective‐Induced Shape Change of Clavicles at Radiography and 3D Scanning to Assist Human Identification
Authors: Stephan Carl N. , Guyomarc'h Pierre 
Published: December 2013

AbstractChange in perspective between antemortem and postmortem imaging sessions (radiograph to radiograph and surface scan to radiograph) may cause different 2D renderings of the same osseous element complicating comparisons for identification. In this study, clavicle shape changes due to radiographic positioning and 3D laser scanning were examined in 20 right‐side specimens, as pertinent to chest radiograph comparisons. Results indicate substantial changes in clavicle form with short source‐to‐image receptor distance, elevation of the element from the image receptor, and movement of the element away from the center beam (10% mean square for shape). Although quantitative shape differences were small when the clavicle was in close opposition to the image receptor (3% mean square), important qualitative differences remained with large distances from the center beam (e.g., conoid tubercle presence/absence). The significance of these results for image superimposition and computer‐automated‐shape‐based searches of radiographic libraries to find matching candidates is discussed.
DART‐MS as a Preliminary Screening Method for “Herbal Incense”: Chemical Analysis of Synthetic Cannabinoids
Authors: Lesiak Ashton D. , Musah Rabi A. , Domin Marek A. , Shepard Jason R. E. 
Published: December 2013

AbstractDirect analysis in real time mass spectrometry (DART‐MS) served as a method for rapid high‐throughput screening of six commercially available “Spice” products, detecting various combinations of five synthetic cannabinoids. Direct analysis in real time is an ambient ionization process that, along with high mass accuracy time‐of‐flight (TOF)‐MS to 0.0001 Da, was employed to establish the presence of cannabinoids. Mass spectra were acquired by simply suspending a small portion of sample between the ion source and the mass spectrometer inlet. The ability to test minute amounts of sample is a major advantage when very limited amounts of evidentiary material are available. In addition, reports are widespread regarding the testing backlogs that now exist because of the large influx of designer drugs. This method circumvents time‐consuming sample extraction, derivatization, chromatographic, and other sample preparative steps required for analysis by more conventional mass spectrometric methods. Accordingly, the synthetic cannabinoids AM‐2201, JWH‐122, JWH‐203, JWH‐210, and RCS‐4 were identified in commercially available herbal Spice products, singly and in tandem, at concentrations within the range of 4–141 mg/g of material. Direct analysis in real time mass spectrometry decreases the time necessary to triage analytical evidence, and therefore, it has the potential to contribute to backlog reduction and more timely criminal prosecution.
Impact of High Hydrostatic Pressure and Pasteurization on the Structure and the Extractability of Bioactive Compounds of Persimmon “Rojo Brillante”
Authors: Hernández‐Carrión M. , Vázquez‐Gutiérrez J. L. , Hernando I. , Quiles A. 
Published: December 2013

AbstractRojo Brillante is an astringent oriental persimmon variety with high levels of bioactive compounds such as soluble tannins, carotenoids, phenolic acids, and dietary fiber. The purpose of this study was to investigate the effects of high hydrostatic pressure (HHP) and pasteurization on the structure of the fruit and on the extractability of certain bioactive compounds. The microstructure was studied using light microscopy, transmission electron microscopy, and low temperature scanning electron microscopy, and certain physicochemical properties (carotenoid and total soluble tannin content, antioxidant activity, fiber content, color, and texture properties) were measured. The structural changes induced by HHP caused a rise in solute circulation in the tissues that could be responsible for the increased carotenoid level and the unchanged antioxidant activity in comparison with the untreated persimmon. In contrast, the changes that took place during pasteurization lowered the tannin content and antioxidant activity. Consequently, HHP treatment could improve the extraction of potentially bioactive compoundsxsts from persimmons. A high nutritional value ingredient to be used when formulating new functional foods could be obtained using HHP.
Aromatic Profile of Ciders by Chemical Quantitative, Gas Chromatography‐Olfactometry, and Sensory Analysis
Authors: Antón María José , Suárez Valles Belén , García Hevia Ana , Picinelli Lobo Anna 
Published: December 2013

AbstractNine samples of Asturias cider have been analyzed for volatile, olfactometric, and sensorial profiles. The aromatic composition was mainly constituted by fusel alcohols and ethyl esters. Among the minor volatile compounds, fatty acids, volatile phenols, and alcohols were the main components. The olfactometric analysis revealed the existence of 55 aromatic areas, exhibiting a wide range of intensities. Components like amyl alcohols, 2‐phenylethanol, ethyl esters such as 2‐methylbutyrate, hexanoate and octanoate, hexanoic and octanoic acids 2‐phenylethyl acetate, 4‐ethyl guaiacol, and 4‐ethyl phenol could be considered as being part of the structure of cider aroma. The extract dilution analysis of one extract identified 2 volatile phenols (4‐ethyl guaiacol and 4‐ethyl phenol) among the most powerful odorants in cider. These components gave significant correlations with the sensory attributes sweet, spicy, and lees.
Trends in Pediatric Visits to the Emergency Department for Psychiatric Illnesses
Authors: Pittsenbarger Zachary E. , Mannix Rebekah 
Published: December 2013

AbstractObjectivesWhile recent studies have demonstrated an overall increase in psychiatric visits in the emergency department (ED), none have focused on a nationally representative pediatric population. Understanding trends in pediatric psychiatric ED visits is important because of limited outpatient availability of pediatric specialists, as well as long wait times for psychiatric appointments. The study aim was to evaluate the trends in ED psychiatric visits for children between 2001 and 2010 with comparison by sociodemographic characteristics.MethodsThis was a retrospective, cross‐sectional analysis of ED psychiatric visits for children < 18 years of age using the National Hospital Ambulatory Medical Care Survey (NHAMCS). Visits were identified by International Classification of Diseases, Ninth Revision (ICD‐9), codes. Outcome measures included frequency of visits for children with psychiatric diagnosis codes and odds and adjusted odds of psychiatric visits controlling for temporal, demographic, and geographic factors.ResultsFrom 2001 to 2010, an average of 28.3 million pediatric visits to EDs occurred annually. Among those, an approximately 560,000 (2% of ED visits) were psychiatric visits each year. Pediatric psychiatric ED visits increased from an estimated 491,000 in 2001 to 619,000 in 2010 (p = 0.01). Teenagers (adjusted odds ratio [AOR] = 3.92, 95% confidence interval [CI] = 3.37 to 4.57) and publicly insured patient visits (AOR = 1.47, 95% CI = 1.25 to 1.74) had increased odds of psychiatric ED visits.ConclusionsPediatric ED psychiatric visits are increasing. Teenagers and children with public insurance appear to be at increased risk. Further investigation is needed to determine what the causative factors are.
Regional cortical thinning may be a biological marker for borderline personality disorder
Authors: Bøen E. , Westlye L. T. , Elvsåshagen T. , Hummelen B. , Hol P. K. , Boye B. , Andersson S. , Karterud S. , Malt U. F. 
Published: December 2013

ObjectiveWe investigated cerebral cortical thickness and its relation to measurements of difficulties with identifying and describing emotions in patients with borderline personality disorder (BPD).MethodEighteen SCID‐II‐diagnosed female patients with BPD and 21 healthy female controls underwent magnetic resonance imaging and completed the Toronto Alexithymia Scale (TAS). First, regional cortical thickness across the cerebral surface was compared between patients and healthy controls. Then, analyses of the association between cortical thickness and TAS subscales were performed in patients.ResultsCompared with controls, patients exhibited clusters of significantly reduced cortical thickness in the left medial and lateral prefrontal cortex, left temporoparietal junction, bilateral temporal poles, and bilateral paracentral lobules. Significant negative associations were observed between cortical thickness and the ‘Difficulties Describing Feelings’ TAS subscale (DDF) scores in patients. The anatomical distribution of these associations was highly overlapping with the group differences in cortical thickness.ConclusionThe pattern of regions exhibiting cortical thinning in patients resembles a network of cortical structures repeatedly shown to be involved in social cognition. The results of the DDF analyses suggest that the thinning may partly be related to interpersonal dysfunction in patients with BPD. The pattern of thinning may represent a potential biological marker for BPD.
Testing the utility of three social‐cognitive models for predicting objective and self‐report physical activity in adults with type 2 diabetes
Authors: Plotnikoff Ronald C. , Lubans David R. , Penfold Chris M. , Courneya Kerry S. 
Published: December 2013

ObjectiveTheory‐based interventions to promote physical activity (PA) are more effective than atheoretical approaches; however, the comparative utility of theoretical models is rarely tested in longitudinal designs with multiple time points. Further, there is limited research that has simultaneously tested social‐cognitive models with self‐report and objective PA measures. The primary aim of this study was to test the predictive ability of three theoretical models (social cognitive theory, theory of planned behaviour, and protection motivation theory) in explaining PA behaviour.MethodsParticipants were adults with type 2 diabetes (n = 287, 53.8% males, mean age = 61.6 ± 11.8 years). Theoretical constructs across the three theories were tested to prospectively predict PA behaviour (objective and self‐report) across three 6‐month time intervals (baseline–6, 6–12, 12–18 months) using structural equation modelling. PA outcomes were steps/3 days (objective) and minutes of MET‐weighted PA/week (self‐report).ResultsThe mean proportion of variance in PA explained by these models was 6.5% for objective PA and 8.8% for self‐report PA. Direct pathways to PA outcomes were stronger for self‐report compared with objective PA.ConclusionsThese theories explained a small proportion of the variance in longitudinal PA studies. Theory development to guide interventions for increasing and maintaining PA in adults with type 2 diabetes requires further research with objective measures. Theory integration across social‐cognitive models and the inclusion of ecological levels are recommended to further explain PA behaviour change in this population.
Statement of contribution

What is already known on this subject?

Social‐cognitive theories are able to explain partial variance for physical activity (PA) behaviour.

What does this study add?

The testing of three theories in a longitudinal design over 3, 6‐month time intervals.

The parallel use and comparison of both objective and self‐report PA measures in testing these theories.
Children's Reasoning About the Refusal to Help: The Role of Need, Costs, and Social Perspective Taking
Authors: Sierksma Jellie , Thijs Jochem , Verkuyten Maykel , Komter Aafke 
Published: December 2013

Children (n = 133, aged 8–13) were interviewed about helping situations that systematically varied in recipient's need for help and the costs for the helper. In situations where helping a peer involved low costs, children perceived a moral obligation to help that was independent of peer norms, parental authority, and reciprocity considerations. When helping a peer involved high costs this overpowered the perceived obligation to help, but only in situations involving low need and when in line with reciprocity. When both need and costs were high, younger children expressed stronger moral indignation while older children were less negative and reasoned in terms of other solutions. Furthermore, stronger moral indignation was related to more advanced social perspective taking skills when need and costs were high.
Preschoolers Reduce Inequality While Favoring Individuals With More
Authors: Li Vivian , Spitzer Brian , Olson Kristina R. 
Published: December 2013

Inequalities are everywhere, yet little is known about how children respond to people affected by inequalities. This article explores two responses—minimizing inequalities and favoring those who are advantaged by them. In Studies 1a (N = 37) and 1b (N = 38), 4‐ and 5‐year‐olds allocated a resource to a disadvantaged recipient, but judged advantaged recipients more positively. In Studies (N = 38) and (N = 74), a delay occurred between seeing the inequality and allocating resources, or stating a preference, during which time participants forgot who was initially more advantaged. Children then favored advantaged recipients on the preference and resource allocation measures, suggesting an implicit “affective tagging” mechanism drives the tendency to favor the advantaged. In contrast, reducing inequalities through resource allocation appears to require explicit reasoning.