bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between early regulatory problems and adult peer relationship quality is mediated by the brain's allostatic‐interoceptive system
Authors: Zorjan Saša , Wolke Dieter , Baumann Nicole , Sorg Christian , Mulej Bratec Satja 
Published: June 2024

BackgroundEarly regulatory problems (RPs), i.e., problems with crying, sleeping, and/or feeding during the first years, increase the risk for avoidant personality traits in adulthood, associated with social withdrawal and anxiety. Even more, RPs are linked with functional alterations in the adult default mode and salience networks, comprising the brain's allostatic‐interoceptive system (AIS) and playing a role in social interactions. We investigated whether RPs assessed in infancy are associated with difficulties in adult peer relationships mediated by functional alterations of the AIS.MethodsAs part of a large case‐controlled prospective study, 42 adults with previous RPs and 70 matched controls (mean age = 28.48, SD = 2.65, 51% male) underwent fMRI during rest. The analysis focused on the intrinsic functional connectivity (iFC) of key nodes of the AIS. Peer relationship quality was assessed via a semi‐structured Life Course Interview and the YASR scale. In these same individuals, RPs were assessed at ages 5, 20 and 56 months.ResultsRPs in infancy were associated with lower‐quality peer relationships and enhanced functional connectivity of the AIS nodes in adulthood, with a stronger effect for multiple and persistent RPs compared with transient‐multiple or single‐persistent RPs. Importantly, iFC changes of the dorsal mid insula, a primary interoceptive cortex with frontal and temporal regions, mediated the relationship between early RPs and adult peer relationship quality.ConclusionsResults indicate long‐lasting social and neural changes associated with early RPs. Our findings further implicate the AIS in both interoceptive and social processes, while indicating the need for early screening of early RPs.
Process optimization for developing ultrasound assisted and microwave dried encapsulated flaxseed oil and its storability
Authors: Keshri Pallavi , Lohani Umesh C. , Shahi Navin C. , Kumar Anil 
Published: June 2024

AbstractTechnological advancement in encapsulating vegetable oil enriched with PUFA has become a new trend to improve stability, preservation, and food application. For microencapsulation of flaxseed oil, spray and freeze drying have been extensively used; however, in this study, ultrasonication along with microwave drying had a significant impact on the encapsulation efficiency (%) and dissolution time (min) of the powder. Analysis of experimental data revealed the optimized condition of microencapsulated flaxseed oil powder at 4.5 g maltodextrin/g of whey protein concentrate, .208 mL oil/g of wall material, and 14 min ultrasonication time. In addition, 6 min of microwave drying at 60 W provided 85.4% encapsulation efficiency, 1.98 meq/kg of oil peroxide value, 4.92 color difference, and 7.08 min dissolution time for the encapsulated powder. Storage studies for 21 days revealed that the peroxide value of raw oil increased by 13 times, whereas microencapsulated powder had only a twofold increase which demonstrated its higher stability when compared with bulk flaxseed oil.Practical applicationsFlaxseed oil is rich in omega‐3 fatty acids, however has poor stability. Encapsulation of flaxseed oil will enhance stability, longer shelf life, and health benefits. Encapsulated oil can be used in dairy and bakery products to increase omega‐3 fatty acids intake and enhance the nutritional values of final products. The current work will recommend the food industries to prepare omega‐3 fatty acids‐rich foods by incorporating encapsulated flaxseed oil.
Effect of flow behavior index of CMC solutions on heat transfer and fluid flow in a cylindrical can
Authors: Dalvi‐Isfahan Mohsen 
Published: June 2024

AbstractThe objective of this study was to investigate the impact of the flow behavior index (n) on heat transfer and fluid flow in carboxymethyl cellulose (CMC) solutions during the thermal process within a cylindrical container. The study employed a numerical model based on the finite element method to solve the governing equations for mass, momentum, and energy conservation. Four different values of n were considered, ranging from 0.25 to 1, representing varying degrees of non‐Newtonian behavior. The results revealed that this index significantly influenced the apparent viscosity of the fluid, subsequently affecting the fluid flow patterns and heat transfer. Specifically, the n = 0.25 fluid exhibited a notably higher Grashof number (GR) and velocity compared to the n = 1 fluid. The average GR for the n = 0.25 fluid was ~2300 times larger than that of the n = 1 fluid, while the average velocity for the n = 0.25 fluid was ~37 times higher. In addition, the study identified the presence of secondary flow in the CMC solution with n = 0.25, which enhanced fluid mixing and heat transfer. Notably, the slowest heating zone for the n = 1 fluid remained fixed at the mid‐height of the can, whereas for the n = 0.25 fluid, it continuously shifted and contracted, ultimately settling at the 10% height from the bottom of the can. These findings underscore the critical importance of considering the non‐Newtonian characteristics of the fluid and convective flow during heat transfer processes in product applications.Practical applicationsThe study investigates the impact of flow behavior indices of the CMC solution on heat transfer and fluid dynamics within cylindrical containers. By examining parameters such as concentration, temperature, and heating duration, the researcher aims to optimize thermal processing for liquid food products containing thickening agents, such as sauces, soups, or dairy items. These findings significantly contribute to ensuring the safety, quality, and nutritional value of diverse liquid food products. Moreover, the study's insights may lead to energy savings and reduced environmental impact by minimizing heating time and temperature during thermal processing. In summary, this research bridges scientific understanding with practical applications, benefiting both consumers and the environment.
Improvement of coconut water shelf‐life through low‐temperature concentration process: Understanding impact of non‐thermal process on shelf‐life
Authors: Pandey Aaditya , Gaikwad Kirtiraj K. , Maiti Abhijit 
Published: June 2024

AbstractFruit juice concentration gains popularity due to the reduced shipping costs for concentrated products. However, the main drawback of the widely used thermal concentration process is the degradation of product's quality parameters. Lyophilization, or the freeze‐drying process, is applied to concentrate coconut water to demonstrate that the quality of the coconut water can improve even when a significant fraction of pure water is removed from it. The measurements of antioxidant activities, total phenolic content (TPC), pH, and titratable acidity are investigated to understand process efficiency without compromising the original quality of coconut water. Study applies first order kinetics to assess the coconut water's shelf‐life, using pH and Brix as critical parameters. Results suggest that Brix, TPC, antioxidant activity (AAO), total dissolved solids (TDS), and potassium increase with increase in lyophilization time, where pH remains the same. The shelf‐life of concentrated product increases to double that of raw coconut water.Practical applicationsCoconut water has very large worldwide demand as health drink across all ages and all societies, particularly has great demand in sport/health sectors. The raw coconut is inconvenient to transport long distances because of its bulky volume. Further, coconut grows in a very limited area, it needs to travel long distance to reach customers across globe. So business with packed concentrated coconut water would be profitable for food industries. There is no study that has proven that concentrated coconut water through non‐thermal processes can actually improve its shelf‐life drastically. This study suggests that Brix, TPC, AAO, total dissolved solids, and potassium ions were concentrated with the increase in lyophilization time, where pH remains same due to an undisturbed natural buffering system. Non‐thermal freeze‐drying techniques proved that non‐thermal treatment like polymeric/ceramic membrane treatment would be beneficial for industry to sell packed coconut water without adding preservatives.
Rapid discovery of natural skin‐lightening ingredients based on an integrated screening strategy based on molecular docking and zebrafish model
Authors: Su Yonghui , Xu Shanshan , Hu Xinqi , Wang Ruifen , Dong Mengxuan , Wang Yihan , Wang Songsong , Zhang Yougang , Tian Qingping , Han Liwen 
Published: June 2024

AbstractBackgroundNatural herbs have been widely considered a reservoir for skin‐lightening ingredients, but discovery of the effective ingredients from herbs remains a large challenge.AimThis research aimed to rapidly identify compounds with skin‐lightening activity in Chinese herbs.MethodsThe structure information of herbal compounds was collected and selected from the open‐source data. High throughput virtual screening (HTVS) and Extra precision (XP) docking modes were used to screen for compounds that could bind to the mushroom tyrosinase involved in melanin synthesis. Furthermore, molecular dynamics (MD) simulations were introduced to assess the binding stability of those compounds with the key target protein. The candidate compounds found by this kind of multidimensional molecular screening were finally tested for their ability to inhibit pigmentation and potential toxicity using an in vivo zebrafish animal model.ResultsA Natural Compounds Database was established with 5616 natural compounds. Fourteen compounds with favorable binding capability were screened by the XP docking mode with mushroom tyrosinase and five compounds among them were found to have superior dynamic binding performance through MD simulations. Then the Zebrafish animal experiments revealed that two components, sennoside B (SB) and sennoside C (SC), could significantly inhibit melanogenesis rather than the other three compounds. Meanwhile, there were no obvious side effects observed in SB and SC about the morphology, heart rate, or body length of zebrafish.ConclusionA strategy for rapid screening of compounds with whitening activity has been established, and two potent skin‐lightening compounds, SB and SC, have been identified from a vast library of herbal compounds. This study revealed that SB and SC have potential for topical use in skin lightening for the first time. The findings of this study would provide an important theoretical basis for the application of these two compounds in the cosmetic field in the future.
A nationwide survey of diagnostic procedures for abnormal uterine bleeding in Japan
Authors: Kitahara Yoshikazu , Hiraike Osamu , Ishikawa Hiroshi , Kugu Koji , Takai Yasushi , Yoshino Osamu , Ono Masanori , Maekawa Ryo , Ota Ikuko , Iwase Akira 
Published: June 2024

AbstractAimTo clarify the diagnostic process of the causative disease of abnormal uterine bleeding (AUB) in Japan according to the International Federation of Gynecology and Obstetrics AUB diagnostic system.MethodsPatients diagnosed with AUB were included in a nationwide survey of AUB conducted during any 2‐week period between December 2019 and January 2020. The second survey included information on patient background, AUB symptoms, examinations for diagnosing AUB, the order in which they were performed, and the causative diseases of AUB.ResultsCorrespondence analysis showed an association between hormonal testing, hysterosalpingography, and magnetic resonance imaging (MRI) in patients with amenorrhea, and heavy menstrual bleeding was strongly correlated with various examinations, such as coagulation tests, pelvic MRI, and endometrial cytology or biopsy. The results also indicated that each AUB causative disease can be diagnosed based on a specific examination profile.ConclusionWe clarified the process of diagnosing the causative disease of AUB in our country and determined that it was mainly diagnosed by imaging and pathological examination in cases of structural disease. The high rate of AUB‐E and the low rate of AUB‐C are possibly associated with specific examination trends in Japan. The results of this study will be useful for the development of a standard protocol for AUB diagnosis in our country.
Linguistics of the heart and mind: Negotiating in one's native language is comfortable but not efficient
Authors: Diaz Adrian Barragan , Marin Jimena Y. Ramirez , Poliakova Elena , Medina Francisco J. 
Published: June 2024

AbstractWhen negotiating with partners from abroad, which language should we choose: a native or a foreign one? To answer this question, we leverage dual‐process theory to investigate how using a native versus foreign language affects negotiation strategies and outcomes and explore the moderating role of emotions. Across three studies that use dual‐language speakers of four of the five most common languages in the world (English, Chinese, Spanish and French), our findings consistently show that, while the native language is the preferred option for negotiation (Study 1), the consequences are more emotional expression, more passive strategies and worse outcomes (Studies 2 and 3). Anger in a native versus foreign language makes negotiators compromise more, which results in worse outcomes (Study 3). Our contribution is threefold: We are the first to explore the effects of language (foreign vs. native) in an empirical negotiation setting; we separate the intrapersonal from the interpersonal effects of language by using the Actor‐Partner Interdependence Model; and we establish that the language effects are independent of culture. Our results suggest that managers should use their native language with caution when negotiating, since they might unconsciously display higher levels of emotion and use more passive negotiation strategies.
Various factors affecting the gel properties of surimi: A review
Authors: Xie Dongfei , Tang Yu , Dong Gua 
Published: June 2024

AbstractAs an important aquatic prepared food, surimi products are favored by consumers due to their unique viscoelastic properties and high nutritional value. Gel properties are the main indicators to measure the quality of surimi products. The gelation of surimi mainly involves intramolecular (conformational change) and intermolecular (chemical force) changes. Factors such as processing treatments, raw fish species and exogenous additives affect surimi protein structure, chemical forces and endogenous enzyme activities, which further affect the gel properties of surimi products. This review focuses on the mechanism of surimi heat‐induced gel, mainly including protein chain expansion and aggregation through various chemical forces to form a three‐dimensional network structure. In addition, the mechanism and application of different factors on the gel properties of surimi were also discussed, providing a reference for the selection of fish species, the control of heating conditions in the gel process of surimi products, the selection of additives and other measures to improve the gel performance.
The Equitable Benefit Approach to guide the assessment of medical and psychosocial factors in liver transplant candidacy
Authors: Craxì Lucia , Cottone Provvidenza M. , Sacchini Dario , Burra Patrizia , Toniutto Pierluigi 
Published: June 2024

AbstractLack of available organs poses a significant challenge in meeting the needs of patients with life‐threatening liver disease who could benefit from liver transplantation (LT). Psychosocial vulnerability markers have been linked to post‐transplant outcomes, raising questions about their use in patient selection. However, their incorporation into selection criteria raises concerns about health equity and potential discrimination. As a result, there is a pressing need to refine fair allocation systems that consider both clinical and psychosocial factors to ensure equitable access and optimize post‐transplant outcomes. The Equitable Benefit Approach (EBA) proposed in this paper by the multidisciplinary group of clinical experts in LT from the Italian Society for the Study of the Liver seeks to address these concerns. It presents four procedural principles, the two allocative principles usually applied in transplantation (urgency and utility) and introduces a new one, the principle of health equity. The EBA aims to prioritize patients with the highest transplant benefit while addressing health inequalities. It emphasizes evidence‐based decision‐making and standardized assessment tools to reliably evaluate psychosocial risk factors. Implementing the EBA involves a multi‐step process, including stakeholder engagement, prospective studies to validate its efficacy, development of institutional policies and algorithms, and ongoing monitoring and revision. By following these steps, health care providers can ensure that LT allocation decisions are transparent and responsive to evolving clinical and social contexts. Ultimately, the EBA should offer a comprehensive framework for fair patient selection in LT, considering both biomedical and psychosocial aspects.
The evolving hierarchy of naturalized philosophy: A metaphilosophical sketch
Authors: Rivelli Luca 
Published: June 2024

AbstractSome scholars claim that epistemology of science and machine learning are actually overlapping disciplines studying induction, respectively affected by Hume's problem of induction and its formal machine‐learning counterpart, the “no‐free‐lunch” (NFL) theorems, to which even advanced AI systems such as LLMs are not immune. Extending Kevin Korb's view, this paper envisions a hierarchy of disciplines where the lowermost is a basic science, and, recursively, the metascience at each level inductively learns which methods work best at the immediately lower level. Due to Hume's dictum and NFL theorems, no exact metanorms for the good performance of each object science can be obtained after just a finite number of levels up the hierarchy, and the progressive abstractness of each metadiscipline and consequent ill‐definability of its methods and objects makes science—as defined by a minimal standard of scientificity—cease to exist above a certain metalevel, allowing for a still rational style of inquiry into science that can be called “philosophical.” Philosophical levels, transitively reflecting on science, peculiarly manifest a non–empirically learned urge to self‐reflection constituting the properly normative aspect of philosophy of science.
Preventive effects of prenatal administration of OM‐85/BV on asthma and respiratory infection risk in the offspring: A review of animal models
Authors: Rahbek‐Hansen Signe Hahn , Mikkelsen Marianne , Stokholm Jakob , Bønnelykke Klaus , Chawes Bo L. , Brustad Nicklas 
Published: June 2024

AbstractAsthma is the most common chronic disease in childhood affecting the daily lives of many patients despite current treatment regimens. Therefore, the need for new therapeutic approaches is evident, where a primary prevention strategy is the ultimate goal. Studies of children born to mothers in farming environments have shown a lower risk of respiratory infections and asthma development. Already at birth, these newborns have demonstrated accelerated maturation and upregulation of host defense immune functions suggesting a prenatal transplacental training of the innate immune system through maternal microbial exposure. This mechanism could possibly be utilized to help prevent both respiratory infections and asthma in young children. Human studies exploring the potential preventative effects of pregnancy bacterial lysate treatment on asthma and respiratory infections are lacking, however, this has been studied in experimental studies using mice through administrations of the bacterial lysate OM‐85. This review will present the current literature on the immunomodulatory effects relevant for respiratory infections and asthma in the offspring of mice treated with OM‐85 throughout pregnancy. Further, the review will discuss the cellular and molecular mechanisms behind these effects. In conclusion, we found promising results of an accelerated immune competence and improved resistance to airway challenges as a result of prenatal bacterial lysate treatment that may pave the way for implementing this in human trials to prevent asthma and respiratory infections.
I believe I can fly… New implications for the mode of life and palaeoecology of the Late Triassic Ozimek volans based on its unique long bone histology
Authors: Konietzko‐Meier Dorota , Teschner Elżbieta M. , Tańczuk Agnieszka , Sander P. Martin 
Published: June 2024

AbstractThe small diapsid reptile Ozimek volans is one of the most enigmatic representatives of the Late Triassic fauna of Krasiejów, Poland. Phylogenetically, Ozimek was identified as a ‘protorosaurian’ related to tanystropheids, but the extremely elongated limbs and presumed gliding abilities are unusual for this group. This raises the question of whether the lifestyle inferred for this taxon is reflected in its bone histology.Two long bones from a single bone association of Ozimek (humerus UOPB 1148a and femur UOPB 1148b) were sectioned at the midshaft to obtain details of the histological framework. A large medullary cavity, thin walls of lamellar bone with numerous lamellae, and only very few simple vascular canals are shared by both bones. Application of a modified 3‐front model (introducing a fourth front) of cortical growth reveals that the femur is ontogenetically younger when compared to the humerus.Ozimek limb bones, with their small diameter, compact structure, low vascularization, no remodelling, and a lack of pneumaticity, are histologically similar to those of modern small bats. The characteristic cortex of both may have been well suited to withstand high loads while limiting weight. The well‐ordered collagen fibres in successive lamellae along the bone may be a key adaptation for the better distribution of the load generated during gliding. © 2024 The Palaeontological Association.
Successful endoscopic approach for peripheral neuroblastic tumors in children
Authors: Kawakubo Naonori , Maniwa Junnosuke , Irie Keiko , Tamaki Akihiko , Fukuta Atsuhisa , Souzaki Ryota , Obata Satoshi , Nagata Kouji , Matsuura Toshiharu , Tajiri Tatsuro 
Published: June 2024

AbstractBackgroundRecently, reports of endoscopic approaches for neuroblastoma, ganglioneuroblastoma, and ganglioneuroma (peripheral neuroblastic tumor; PNTs) have been increasing. This study aimed to clarify the indications for endoscopic surgery for PNTs.MethodsPediatric patients who underwent endoscopic surgery for PNTs at our institution were included in this study. Image‐defined risk factors (IDRFs) were analyzed using preoperative computed tomography (CT).ResultsTwenty‐four patients underwent endoscopic surgery for PNTs. The diagnoses included neuroblastoma (n = 11), ganglioneuroma (n = 10), and ganglioneuroblastoma (n = 3). Regarding the tumor site, there were 18 cases of adrenal tumors, five cases of mediastinal tumors, and one case of retroperitoneal tumors. Image‐defined risk factors were positive in eight cases (contacted with a renal vessel, n = 6; compression of principal bronchi, n = 2). Complete resection was accomplished in 21 cases (14 of 16 IDRF‐negative cases and seven of eight IDRF‐positive cases). All patients survived without recurrence during the follow‐up period.ConclusionsThe CT findings of contact with renal vessels and compression of principal bronchi do not seem to be indicators of incomplete resection. An endoscopic approach to PNTs in pediatric patients is feasible with a good prognosis if patients are selected strictly.