bluuebunny/crossref_metadata_2025_split huggingface dataset:
FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
Authors: Collip Dina , Myin-Germeys Inez , Wichers Marieke , Jacobs Nele , Derom Catherine , Thiery Evert , Lataster Tineke , Simons Claudia , Delespaul Philippe , Marcelis Machteld , van Os Jim , van Winkel Ruud 
Published: February 2013

BackgroundFK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma.AimsTo examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype.MethodIn 401 general population twins, four functional polymorphisms were examined in models of psychosis and Cortisol, and followed up in models of psychosis in three samples at different familial liability (175 controls, 200 unaffected siblings and 195 patients with a psychotic disorder).ResultsThe most consistent finding was an interaction between childhood trauma and rs9296158/rs4713916 on psychotic symptoms and Cortisol in the twin sample, combined with a directionally similar interaction in siblings (rs4713916) and patients (rs9296158), A-allele carriers at both polymorphisms being most vulnerable to trauma.ConclusionsTrauma may increase the risk of psychosis through enduring changes in the Cortisol feedback loop, similar to that for PTSD, suggesting comparable biological mechanisms for psychosis across diagnostic boundaries.
Decreasing the Cutoff for Elevated Blood Lead (EBL) Can Decrease the Screening Sensitivity for EBL
Authors: McCloskey Laura J. , Bordash Frank R. , Ubben Kathy J. , Landmark James D. , Stickle Douglas F. 
Published: February 2013

Abstract
Change in the definition of elevated blood lead (EBL) from greater than or equal to 10 μg/dL (cutoff A) to greater than or equal to 5 μg/dL (cutoff B) was recently endorsed in the United States. A potential effect of this change is to decrease the screening sensitivity for EBL detection. We demonstrate this effect by simulated sampling of an example patient distribution for lead. Using lead-dependent assay imprecision, simulated sampling of the patient distribution tracked individual misclassifications relative to the EBL cutoff. Decreasing the EBL cutoff from A to B reduced screening sensitivity for EBL detection in this population to less than 90%, a decrease of 4%. The result was due to the fact that, for B, a greater fraction of the EBL population was near the EBL cutoff and therefore subject to misclassification due to assay imprecision. The effect of the decreased EBL cutoff to reduce EBL screening sensitivity is likely to apply to EBL screening programs generally.
Risk-Benefit Analysis of Sampling Methods for Fine-Needle Aspiration Cytology: A Mathematical Modeling Approach
Authors: Schmidt Robert L. , Kordy Michal A. , Howard Kirsten , Layfield Lester J. , Hall Brian J. , Adler Douglas G. 
Published: February 2013

Abstract
The effectiveness of fine-needle aspiration (FNA) increases with the number of needle passes, but needle passes are also associated with increased risk of adverse events. The trade-off between needle passes and adequacy has not been well characterized. Clinical studies are limited because of their inherent variability and limited sample size. We developed mathematical models to compare the performance of a variety of sampling protocols under a wide range of conditions. Specifically, we compared the performance of sampling methods using a fixed number of needle passes with sampling methods using a rapid onsite evaluation (ROSE) with a variable number of needle passes. Variable sampling with ROSE generally required fewer needle passes than fixed sample size policies to achieve a desired adequacy rate. Variable sampling policies using ROSE achieve greater per-case adequacy with fewer needle passes than sampling policies using a fixed number of passes if assessor accuracy is high.
First-principles study of electronic structure and optical properties of Sr(Ti,Zr)O3
Authors: Celik Gulden , Cabuk Suleyman 
Published: February 2013

Abstract
Electronic and optical properties of Sr(Ti,Zr)O3 crystals in the cubic (Pm-3m) and tetragonal (I4/mcm) phase were calculated by the first-principles calculations using the density functional theory and the local density approximation. The band structure of cubic and tetragonal phases show an indirect band gap at (R-Γ) point and at (M-Γ) point in the Brillouin zone, respectively. The linear photon-energy dependent dielectric functions and some optical properties such as the absorption coefficient, energy-loss function and reflectivity are calculated for both phases. The optical properties of tetragonal phase of Sr(Ti,Zr)O3 were investigated by theoretical methods for the first time. We have also made some comparisons with the available related experimental and theoretical data.
High-Sensitivity C-Reactive Protein in Patients with Polycystic Ovary Syndrome
Authors: Iuhas Cristian-Ioan , Costin Nicolae , Mihu Dan 
Published: February 2013

AbstractObjective: To assess the inflammation evaluated by high sensitivity C ReactiveProtein (hsCRP) in women with polycystic ovary syndrome (PCOS) compared withhealthy women without PCOS. Methods: This was a retrospective, case control,observational study. The study group included 31 patients with PCOS and 29 healthypatients matched for age and body mass index (BMI) but without PCOS (controlgroup). PCOS was diagnosed using Rotterdam criteria. Results: Patients with PCOShad higher mean hsCRP levels compared with healthy controls: 3.89±2.75 mg/l inPCOS group and 2.61±1.81 mg/l in the control group, p=0.04. The difference was nolonger significant after adjustment for BMI. In the PCOS group hsCRP waspositively correlated with BMI, waist circumference, visceral fat area, body fat massand glycated hemoglobin (HbA1c). Conclusion: hsCRP levels are increased inpatients with PCOS and are correlated with obesity, fat accumulation and not withthe presence of PCOS per se.
Community Matters for Children’s Health
Authors: Johnson Sheri , Dickinson Katherine , Mandic Carmen Gomez , Willis Earnestine 
Published: February 2013

CME Educational Objectives

1.
Describe a cross-theoretical conceptualization of how community factors affect children’s health.

2.
Provide examples of how community conditions affect common health concerns often faced by health professionals in the clinical setting.

3.
Identify opportunities to leverage professional knowledge of community conditions and public policy to improve the health of children.

What makes us healthy? Providing guidance to families regarding prevention and diagnosing and treating illness are the foundations of clinical practice. Yet medical care directed at improving and preserving the health of the individual patient accounts for only about 15% to 20% of what makes us healthy at a population level. Community factors, such as the quality of housing, safety of neighborhoods, and availability of livable-wage jobs for adults, frequently referred to as social determinants of health, account for a much larger proportion of what makes people healthy.
1
Impact of Overweight and Obesity on Left Ventricular Diastolic Function and Value of Tissue Doppler Echocardiography
Authors: Kossaify Antoine , Nicolas Nayla 
Published: February 2013

Background Diastolic dysfunction is a common cause of heart failure with preserved systolic function in obese patients. Objective To assess diastolic function in a series of overweight and obese patients using conventional and tissue Doppler echocardiography. Setting and Method University hospital; left ventricular diastolic function was evaluated in 99 patients (mean age 61.59 ± 13.9 years); body mass index and waist circumference were assessed, and patients were subdivided into three groups according to their body mass index (kg/m2): [normal, (18.5-24.9); overweight, (25-29.9); obese, (> 29.9)]. Peak early (E) and late (A) transmural flow and peak early (E′) diastolic mitral annulus velocities were measured. Results Diastolic dysfunction was significantly higher in the overweight/obese groups compared to the normal body mass index group. The analysis was made with regard to waist circumference and other clinical characteristics, and multivariate regression analysis showed a direct and independent effect of body mass index on diastolic function [OR: 2.75; CI: 1.34-5.67; P = 0.006]. Discussion was made in view of the latest clinical data. Also, an insight into normal weight obesity is presented and discussed. Conclusion Overweight and obesity are found to have an independent negative impact on diastolic function as assessed by tissue Doppler imaging.
Beyond Point Measurements: Sea Ice Floes Characterized in 3‐D
Authors: Williams Guy D. , Maksym Ted , Kunz Clayton , Kimball Peter , Singh Hanumant , Wilkinson Jeremy , Lachlan‐Cope Tom , Trujillo Ernesto , Steer Adam , Massom Rob , Meiners Klaus , Heil Petra , Lieser Jan , Leonard Katherine , Murphy Chris 
Published: February 2013

A new methodology for coincident floe‐scale measurements of the surface elevation, snow depth, and ice draft (the thickness below the water line) of Antarctic sea ice has been demonstrated during two recent research voyages: the Australian‐led Sea Ice Physics and Ecosystem Experiment II (SIPEX II) to East Antarctica in September–November 2012 and the United Kingdom–led Ice Mass Balance in the Bellingshausen Sea (ICEBell) voyage to the Weddell and Bellingshausen Seas in November 2010 (Figure 1a).
Synthesis and Optical Properties of Tetraaryl‐1,4‐dihydropyrrolo[3,2‐b]pyrroles
Authors: Janiga Anita , Glodkowska‐Mrowka Eliza , Stoklosa Tomasz , Gryko Daniel T. 
Published: February 2013

AbstractA practical synthesis of nonfused 1,4‐dihydropyrrole[3,2‐b]pyrroles in a domino reaction of aldehydes, primary amines, and butane‐2,3‐dione has been discovered. Six bonds are formed in a tandem process, which gives rise to tetrasubstituted pyrrole[3,2‐b]pyrroles—the least studied among heteropentalenes. Unparalleled simplicity and versatility of this one‐pot reaction, no chromatography, as well as superb optical properties have the potential to make 1,4‐dihydropyrrole[3,2‐b]pyrroles the molecules of choice for various applications. As a proof of principle, cell uptake of selected dyes was demonstrated.
Solubility prediction of gases in polymers using fuzzy neural network based on particle swarm optimization algorithm and clustering method
Authors: Li Mengshan , Huang Xingyuan , Liu Hesheng , Liu Bingxiang , Wu Yan , Deng Xiaozhen 
Published: February 2013

AbstractA four‐layer fuzzy neural network (FNN) model combining particle swarm optimization (PSO) algorithm and clustering method is proposed to predict the solubility of gases in polymers, hereafter called the CPSO‐FNN, which combined fuzzy theory's better adaptive ability, neural network's capability of nonlinear and PSO algorithm's global search ability. In this article, the CPSO‐FNN model has been employed to investigate solubility of CO2 in polystyrene, N2 in polystyrene, and CO2 in polypropylene, respectively. Results obtained in this work indicate that the proposed CPSO‐FNN is an effective method for the prediction of gases solubility in polymers. Meanwhile, compared with traditional FNN, this method shows a better performance on predicting gases solubility in polymers. The values of average relative deviation, squared correlation coefficient (R2) and standard deviation are 0.135, 0.9936, and 0.0302, respectively. The statistical data demonstrate that the CPSO‐FNN has an outstanding prediction accuracy and an excellent correlation between prediction values and experimental data. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Actinotetraoses I–K: Tetrasaccharide Metabolites Produced by an Insect‐Derived Actinobacteria, Amycolatopsis sp. HCa1
Authors: Guo Zhi‐Kai , Jiao Rui‐Hua , Dai Hao‐Fu , Mei Wen‐Li , Tan Ren‐Xiang , Ge Hui‐Ming 
Published: February 2013

AbstractAn isolate of rare actinobacteria strain Amycolatopsis sp. HCa1 obtained from the gut of grasshopper produced seven different metabolites in vitro. The metabolites isolated from its mycelia cakes were characterized by NMR and MS analyses. Actinotetraose hexatiglate (or tigloside; 1) with nonreducing glucotetraose skeleton was isolated as a major constituent; three new tetrasaccharide derivatives actinotetraoses I–K (2–4, resp.) and three known actinotetraoses A–C (5–7, resp.) were also isolated.
Tungsten Redox Waves in [XMW11O40]n– (X = P, Si, Al and M = W, Mo, V, Nb, Ti) Keggin Compounds – Effect of Localised/Delocalised Charges
Authors: Aparicio Pablo A. , Poblet Josep M. , López Xavier 
Published: February 2013

AbstractIn the 1960s, Pope and co‐workers found a linear dependence between the redox potentials of a family of isostructural α‐[XW12O40]n– Keggin anions and their molecular charge with a slope of –0.18 V per unit charge. That finding was restricted to variations in the internal atom or heteroatom of the molecule (X = PV, SiIV, AlIII, etc.). However, other ways to change the charge of Keggin anions are commonplace, such as previous reduction processes or chemical changes in the external positions of the W12O36 cage, and also lead to variations in their oxidising power. In the present theoretical work, we analyse the oxidising power, computed as reduction energies, for a family of differently charged α‐[XMW11O40]n– Keggin derivatives (X = P, Si, Al and M = W, Mo, V, Nb, Ti). The nature of the unitary charge increment affects the reduction energy differently; the mildest change occurs upon variations in the internal position (heteroatom substitution), and the strongest change (by a factor of ca. 1.85 per additional charge unit compared to the previous one) occurs in the presence of a delocalised (or “blue”) electron. The replacement of a metal atom (M) from an external position by another one with different oxidation state has an intermediate effect.
Validation of a dual in vivo–in vitro assay for predicting the digestibility of nutrients in humans
Authors: Coles Leah T , Moughan Paul J , Awati Ajay , Darragh Alison J 
Published: February 2013

AbstractBackgroundThe validation of a dual in vivo–in vitro digestibility assay (‘dual digestibility assay’) for separately predicting the upper‐tract, hindgut and total tract digestibility of nutrients in humans, as estimated using organic matter digestibility (OMD), is described. Human upper‐tract OMD was predicted using an animal (rat) model with digesta from the terminal ileum collected from rats fed one of four complete human diets (wheat bran diet, pectin diet, mixed low‐fibre diet, mixed high‐fibre diet). Large intestinal OMD was predicted using an in vitro hindgut fermentation assay employing a human faecal inoculum and with the rat ileal digesta as the substrate.ResultsA comparison of total tract OMD of the four diets from a human balance study (OMDhuman) with that predicted using the dual digestibility assay (OMDdual) showed no significant differences (P > 0.05). OMDhuman and OMDdual were highly correlated (r = 0.953, P = 0.047).ConclusionThe dual digestibility assay accurately predicts the uptake of dietary nutrients (as grams of organic matter) in humans over the total tract. The assay is able to separately quantify the digestibility of nutrients in the upper and lower digestive tracts. The validation of the dual digestibility assay needs to be extended to a wider range of human diets. © 2013 Society of Chemical Industry
Co‐delivery of 10‐Hydroxycamptothecin with Doxorubicin Conjugated Prodrugs for Enhanced Anticancer Efficacy
Authors: Zhang Yu , Xiao Chunsheng , Li Mingqiang , Chen Jie , Ding Jianxun , He Chaoliang , Zhuang Xiuli , Chen Xuesi 
Published: February 2013

AbstractWell‐defined amphiphilic linear‐dendritic prodrugs (MPEG‐b‐PAMAM‐DOX) are synthesized by conjugating doxorubicin (DOX), to MPEG‐b‐PAMAM through the acid‐labile hydrazone bond. The amphiphilic prodrugs form self‐assembled nanoparticles in deionized water and encapsulate the hydrophobic anticancer drug 10‐hydroxycamptothecin (HCPT) with a high drug loading efficiency. Studies on drug release and cellular uptake of the co‐delivery system reveal that both drugs are released in a pH‐dependent manner and effectively taken up by MCF‐7 cells. In vitro methyl thiazolyl tetrazolium (MTT) assays and drug‐induced apoptosis tests demonstrate the HCPT‐loaded nanoparticles suppress cancer cell growth more efficiently than the MPEG‐b‐PAMAM‐DOX prodrugs, free HCPT, and physical mixtures of MPEG‐b‐PAMAM‐DOX and HCPT at equivalent DOX or HCPT doses. magnified image
Kurzzeit‐Tomosynthese — Dreidimensionale Röntgenabbildung
Authors: Weiss H. , Linde R. , Klotz E. 
Published: February 2013

AbstractIm Gegensatz zu tomographischen Verfahren, bei denen eine einzige Röntgenröhre kontinuierlich um ein Objekt herumgeführt wird, liegt den Tomosynthese‐Verfahren das Prinzip zugrunde, ein Objekt mit vielen Röntgenröhren in festen Positionen aufzunehmen und auf diese Weise ein kodiertes Bild zu erzeugen. In einem zweiten Schritt, der Dekodierung, lassen sich dann Bilder von beliebig wählbaren Schichten des Objekts rekonstruieren.
Möglichkeiten und Probleme der Nutzung von Sonnenenergie
Authors: Lehner G. 
Published: February 2013

AbstractDer vorliegende Aufsatz ist die stark gekürzte Fassung eines Vortrages, den der Autor im Rahmen einer öffentlichen Ringvorlesung der Universität Erlangen‐Nürnberg mit dem Thema “Auf der Suche nach neuen Energiequellen” im Sommersemester 1981 gehalten hat. Die gesamte Vortragsreihe wird in Buchform in der Reihe “Erlanger Forschungen” im Verlag des Universitätsbundes Erlangen‐Nürnberg erscheinen.
Elektroneneinfang in Stößen zwischen hochgeladenen Ionen und Atomen
Authors: Salzborn Erhard 
Published: February 2013

AbstractDer Einfang von Elektronen gehört zu den grundlegenden Elementarprozessen in Ion‐Atom‐Stößen. Der Elektroneneinfang hochgeladener Ionen hat insbesondere im Zusammenhang mit heißen Plasmen in der Kernfusionsforschung und in der Astrophysik große Bedeutung. Der Aufsatz gibt einen Überblick über die Physik von Ladungstransferprozessen in Stößen zwischen hochgeladenen Ionen und Atomen.
Neutrinoastrophysik und Neutrinoruhmasse: II. Sonnenneutrinos und Sternkollapsneutrinos
Authors: Kirsten Till 
Published: February 2013

AbstractIm Juli‐Heft wurde im ersten Teil dieses Artikels die enge und wechselseitige Verknüpfung zwischen Astrophysik, Kosmologie, Elementarteilchenphysik und der physikalischen Natur des Neutrinos behandelt. Dabei kam insbesondere der Frage nach der Ruhmasse der Neutrinos große Bedeutung zu. Der vorliegende zweite Teil des Artikels konzentriert sich auf Experimente zum Nachweis der solaren Neutrinos. Nur die bei der Fusion erzeugten Neutrinos erlauben aufgrund ihrer geringen Wechselwirkung mit Materie einen Blick in das anderweitig unzugängliche Sonneninnere und damit die Überprüfung unserer Vorstellungen vom Sternaufbau. Auch hier ist die Neutrinoruhmasse wichtig, weil dadurch ermöglichte Neutrino‐Oszillationen den im Detektor auf der Erde nachweisbaren Fluß solarer Neutrinos reduzieren können. Selbst bei Ruhmassen noch unterhalb 10−3 eV kann das in Arbeit befindliche Gallium‐Solarneutrino‐Experiment darüber eine Entscheidung herbeiführen. Am Schluß werden Neutrinopulse aus dem Kollaps sterbender Sterne behandelt.
Instituto de Sistemas Fotovoltaicos de Concentración concentration photovoltaics hybrid system first year of operation and improvements
Authors: Trujillo Serrano Pablo Jesus , Alamillo Davila Cesareo , Martínez Montes Maria , de la Rubia Oscar , Rubio Francisca , Masa‐Bote Daniel , Castillo‐Cagigal Manuel , Matallanas Eduardo , Caamaño‐Martín Estefania , Gutiérrez Alvaro 
Published: February 2013

ABSTRACTA photovoltaic (PV) hybrid system combines PV with other forms of electricity generation, usually a diesel generator. The system presented in this paper uses concentration photovoltaic (CPV) as the main generator in combination with a storage system and the grid, configured as the backup power supply. The load of the system consists of an air conditioning system of an office building. This paper presents the results obtained from the first months of operation of the CPV hybrid system installed at Instituto de Sistemas Fotovoltaicos de Concentración facilities together with exhaustive simulations in order to model the system behaviour and be able to improve the self‐consumption ratio. This system represents a first approach to the use of a CPV in office buildings complemented by an existing AC‐coupled hybrid system. The contribution of this paper to the analysis of this new system and the existing tools available for its simulation, at least a part of it, can be considered as a starting point for the development of these kinds of systems. Copyright © 2013 John Wiley & Sons, Ltd.
Magnetism and superconductivity in EuFe2As2 synthesized under high pressure
Authors: Tsvyashchenko A. V. , Sidorov V. A. , Fomicheva L. N. , Gofryk K. , Sadykov R. A. , Thompson J. D. 
Published: February 2013

AbstractWe have synthesized polycrystalline samples of EuFe2As2 by melting the stoichiometric mixture of constituent components at a high pressure (HP) of 8 GPa and measured the properties of HP‐synthesized samples at ambient and high pressure up to 6 GPa. SDW‐type antiferromagnetism appears below 150 K and Eu‐related antiferromagnetism appears below 16 K in all HP synthesized samples. Also, all HP‐synthesized samples exhibit superconductivity with Tc = 20–30 K at ambient pressure, though a zero‐resistance state has not been observed. This superconductivity is very robust against application of magnetic field (dHc2/dT = −3.2 T K−1) and pressure (a tiny signal of superconductivity is still detectable below 2.5 K at 5.8 GPa). SDW antiferromagnetism is suppressed under pressure and is not observed above 1.7 GPa and below 60 K. The temperature of the magnetic ordering of Eu2+ moments increases under pressure. Specific heat measurements in a magnetic field reveal an increase of this temperature in field, therefore indicating field‐induced ferromagnetism in the Eu sublattice.
Validity of the Patient Specific Functional Scale in Patients following Upper Extremity Nerve Injury
Authors: Novak Christine B. , Anastakis Dimitri J. , Beaton Dorcas E. , Mackinnon Susan E. , Katz Joel 
Published: February 2013

Purpose This study evaluated the validity of the Patient Specific Functional Scale (PSFS) in patients with upper extremity nerve injury. Methods Following Research Ethics Boards (REB) approval, we included English-speaking adults, with greater than 6 months after an upper extremity nerve injury. Patient reported questionnaires included: PSFS, 36-item short-form health survey (SF-36), Disabilities of the Arm, Shoulder and Hand (DASH), McGill Pain Questionnaire, Pain Catastrophizing Scale (PCS) and Pain Disability Index (PDI). Statistical analyses evaluated the relationships among the outcome measures and the independent variables (age, gender, nerve injured, time since injury, work status, worker's compensation/litigation). Linear regression was used to evaluate the variables that predicted the PSFS. Results There were 157 patients (53 women, 104 men); median time since injury of 14 months. The mean ± SD scores were: PSFS 3.1 ± 2.3, DASH 44 ± 22, PCS 16 ± 15, pain intensity 4.2 ± 3.0, pain rating index 13 ± 11, PDI 28.3 ± 17.6 and SF-36 component scores physical (41.8 ± 8.7) mental (45.9 ± 12.6). There were moderate correlations between the PSFS and the DASH, and the SF-36 physical role domain. The PSFS was significantly lower in brachial plexus injuries. The final model explained 20.7 % of the variance and independent variables were DASH, nerve injured and age. Conclusion This study provides evidence of construct validity of the PSFS for patients with upper extremity nerve injury. The PSFS is a valid method to assess functional limitations identified by the individual and can be completed in a shorter period of time than the DASH.