bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrocardiographic effects of class 1 selective histone deacetylase inhibitor romidepsin
Authors: Sager Philip T. , Balser Barbara , Wolfson Julie , Nichols Jean , Pilot Richard , Jones Suzanne , Burris Howard A. 
Published: April 2015

AbstractRomidepsin is a histone deacetylase inhibitor approved by the FDA for the treatment of patients with cutaneous or peripheral T‐cell lymphoma who have received prior systemic therapy. The objective of this analysis was to evaluate the potential QTc effects of romidepsin. Patients with advanced malignancy received 4‐h infusions of 14 mg/m2 romidepsin on days 1, 8, and 15 of a 28‐day cycle. In cycle 2, a subset of patients received 1‐h infusions of 8–12 mg/m2 romidepsin. Patients were administered antiemetics before each romidepsin dose and electrolyte supplementation as needed. Electrocardiogram readings were performed prior to antiemetic administration, prior to romidepsin administration, and at specified time points over the subsequent 24 h. Romidepsin exposure and heart rate were also assessed. In the electrocardiogram‐evaluable population, 26 patients received romidepsin at 14 mg/m2 over 4 h. The maximum mean increases from the preantiemetic baseline for QTcF and heart rate were 10.1 msec (upper 90% CI, 14.5 msec) and 18.2 beats per minute, respectively. No patient in this study had an absolute QTcF value >450 msec and only one patient had an increase from the preantiemetic baseline of >60 msec. There was a mild reduction in the PR interval and no meaningful changes in the QRS interval. Despite the use of QT‐prolonging antiemetics, treatment with romidepsin did not markedly prolong the QTc interval through 24 h. Increases in calculated QTc may have been exaggerated as a consequence of transient increases in heart rate.
At what age should screening mammography be recommended for Asian women?
Authors: Tsuchida Junko , Nagahashi Masayuki , Rashid Omar M , Takabe Kazuaki , Wakai Toshifumi 
Published: April 2015

AbstractAlthough regular screening mammography has been suggested to be associated with improvements in the relative survival of breast cancer in recent years, the appropriate age to start screening mammography remains controversial. In November 2009, the United States Preventive Service Task Force published updated guidelines for breast cancer, which no longer support routine screening mammography for women aged 40–49 years, but instead, defer the choice of screening in that age group to the patient and physician. The age to begin screening differs between guidelines, including those from the Task Force, the American Cancer Society and the World Health Organization. It remains unclear how this discrepancy impacts patient survival, especially among certain subpopulations. Although the biological characteristics of breast cancer and peak age of incidence differ among different ethnic populations, there have been few reports that evaluate the starting age for screening mammography based on ethnicity. Here, we discuss the benefits and harm of screening mammography in the fifth decade, and re‐evaluate the starting age for screening mammography taking ethnicity into account, focusing on the Asian population. Breast cancer incidence peaked in the fifth decade in Asian women, which has been thought to be due to a combination of biological and environmental factors. Previous reports suggest that Asian women in their 40s may receive more benefit and less harm from screening mammography than the age‐matched non‐Asian US population. Therefore, starting screening mammography at age 40 may be beneficial for women of Asian ethnicity in well‐resourced countries, such as Japanese women who reside in Japan.
Growth Rate Dispersion at the Single‐Crystal Level
Authors: Bobo Emilie , Petit Samuel , Coquerel Gérard 
Published: April 2015

AbstractEvidence of growth rate dispersion for symmetry‐related opposite faces of centrosymmetric single crystals of ammonium perchlorate is provided. Crystallization experiments conducted by evaporation of a stagnant aqueous solution at room temperature show that some $ ({\rm{hkl}}) $ faces have high and irregular normal growth rates, in time and space, whereas the corresponding $ ({\rm{\overline h}}\;{\rm{\overline k}}\;{\rm{\overline l}}) $ faces crystallize slowly and steadily. The $ ({\rm{hkl}}) $ faces presenting high and irregular crystal growth also form repetitive inclusions, whereas $ ({\rm{\overline h \;\overline k \; \overline l}}) $ faces are not involved in any formation of vacuoles. As a consequence, it is possible to retrace the crystallization history of a single crystal by analyzing the location of series of inclusions showing the progressive displacement of its center of gravity.
N‐Doped TiO2/SrTiO3 Heterostructured Nanotubes for High‐Efficiency Photoelectrocatalytic Properties under Visible‐Light Irradiation
Authors: Huang Juan‐Ru , Tan Xin , Yu Tao , Hu Wen‐Li , Zhao Lin , Liu Hang , Zhang Ling , Zou Yun‐Ling 
Published: April 2015

AbstractN‐doped TiO2/SrTiO3 heterostructured nanotubes with a highly reactive {001} facet of anatase TiO2 are fabricated by a combination of traditional anodization and conventional hydrothermal treatment. The photoelectrocatalytic and photoelectrochemical properties of the resulting nanotubes are investigated through the degradation of methylene blue and measurements of transient photocurrent and open‐circuit voltage, and the results are compared with those obtained with reference TiO2 and N‐doped TiO2 nanotubes. The synthesis principles and degradation mechanisms are also presented and discussed. The results clearly show that these heterostructured nanotubes have enhanced photoelectrocatalytic and photoelectrochemical properties under UV and visible‐light irradiation, and that the positive synergistic effect of N incorporation, dominant {001} facet of TiO2, and directional migration of photogenerated charges at the heterostructured interface can cooperatively promote the transfer and separation of the photogenerated carriers.
Hexaphenylbenzene‐Based, π‐Conjugated Snowflake‐Shaped Luminophores: Tunable Aggregation‐Induced Emission Effect and Piezofluorochromism
Authors: Chang Zheng‐Feng , Jing Ling‐Min , Wei Cong , Dong Yu‐Ping , Ye Yan‐Chun , Zhao Yong Sheng , Wang Jin‐Liang 
Published: April 2015

AbstractIn this work, two rigid, multiple tetraphenylethene (TPE)‐substituted, π‐conjugated, snowflake‐shaped luminophores BT and BPT were facilely synthesized by using a 6‐fold Suzuki coupling reaction. These molecules are constructed based on the nonplanar structure of propeller‐shaped hexaphenylbenzene (HPB) or benzene as core groups and TPE as end groups. As a result, they reserve the intrinsic aggregation‐induced emission (AIE) property of the TPE moiety. Meanwhile, both fluorescence quantum yield and piezochromic behavior in the solid state can be tuned or switched by inserting the phenyl bridges through changing the twisting conformation. The more extended structure BPT showed a much stronger AIE effect and higher ΦF,f in the solid state in comparison with that of BT. Furthermore, an excellent optical waveguide application of these molecules was achieved. However, the revisable piezofluorochromic behavior has only appeared when BT was ground using a pestle and treated with solvent.
Dynamic Aminal‐Based TPA Ligands
Authors: Zhou Yuntao , Yuan Yaofeng , You Lei , Anslyn Eric V. 
Published: April 2015

AbstractThe use of dynamic covalent reactions (DCRs) is gaining popularity for the construction of self‐assembling architectures. We have recently introduced DCRs that exchange alcohols and aldehydes to create hemiaminal ethers within tri(2‐picolyl)amine (TPA) ligands, all of which are templated by ZnII. To expand the scope of this assembly, aromatic imines derived from pyridine‐2‐carboxyaldehyde were explored as dynamic covalent receptors for di(2‐picolyl)amine in the presence of ZnII to create TPA ligands that contain aminal linkages. This represents another metal‐templated in situ multicomponent assembly. The stability of the assembly was successfully modulated through substituent effects, and the equilibrium constants from imines to aminals were correlated by a linear free energy relationship (LFER) with σ+ values. Dynamic component exchange was investigated as a means of probing multiple equilibriums quantitatively in the system. Further, the mechanism was analyzed with a qualitative kinetics study. NMR spectra reveal the different extents of two competing pathways for assembly depending upon whether the aromatic amine has electron‐withdrawing or electron‐donating groups on the ring. Finally, mass spectral evidence supports the presence and differing extents of dominance of the two pathways as a function of the substituents.
ChemInform Abstract: Synthesis and Crystal Structure of the Black Material AgMnII3 (MnIII0.26Al0.74) (MoO4)5.
Authors: Bouzidi Chahira , Frigui Wafa , Zid Mohamed Faouzi 
Published: April 2015

AbstractAgMnII3 (MnIII0,26Al0,74) (MoO4)5 is prepared by solid state reaction of a 1:1:3:5 molar mixture of Al2O3, AgNO3, Mn(OAc)3·2H2O, and (NH4)2Mo4O13 (porcelain crucible, 1143 K, 4 weeks).
ChemInform Abstract: Growth, Structure, and Optical Properties of a Self‐Activated Crystal: Na3Nd9O3(BO3)8.
Authors: Shan Faxian , Xia Mingjun , Zhang Guochun , Yao Jiyong , Zhang Xinyuan , Xu Tianxiang , Wu Yicheng 
Published: April 2015

AbstractViolet crystals of the title compound are prepared from a mixture of Na2CO3, Nd2O3, B2O3, and NaF in the molar ratio of 9:2:14:10 (Pt crucible, 950 °C, 16 h).
ChemInform Abstract: Quaternary Rare‐Earth Selenides with Closed Cavities: Cs[RE9Mn4Se18] (RE: Ho—Lu).
Authors: Lin Hua , Shen Jin‐Ni , Shi Yong‐Fang , Li Long‐Hua , Chen Ling 
Published: April 2015

AbstractThe title compounds are prepared by reactions of the elements in a reactive CsCl flux (1223 K, 6 d).
ChemInform Abstract: Catalytic Asymmetric Alkylation of Aryl Heteroaryl Ketones.
Authors: Ortiz Pablo , del Hoyo Ana M. , Harutyunyan Syuzanna R. 
Published: April 2015

AbstractA new strategy to access chiral tertiary diarylmethanols through copper‐catalyzed direct alkylation of (di)(hetero)aryl ketones by using Grignard reagents is developed.
ChemInform Abstract: Visible‐Light‐Induced Bromoetherification of Alkenols for the Synthesis of β‐Bromotetrahydrofurans and ‐tetrahydropyrans
Authors: Lin Run , Sun Hongnan , Yang Chao , Yang Youdong , Zhao Xinxin , Xia Wujiong 
Published: April 2015

Abstractusing CBr4 as bromine source
ChemInform Abstract: Tethered Ru(II) Catalysts Containing a Ru—I Bond.
Authors: Jolley Katherine E. , Clarkson Guy J. , Wills Martin 
Published: April 2015

AbstractTwo new iodide‐containing derivatives of widely‐used Ru(II) (arene)(TosDPEN) catalysts are synthesized and evaluated in the asymmetric reduction of acetophenone under both transfer (ATH) and pressure hydrogenation (AH) conditions.
ChemInform Abstract: Metal‐Free σ‐Bond Metathesis in 1,3,2‐Diazaphospholene‐Catalyzed Hydroboration of Carbonyl Compounds.
Authors: Chong Che Chang , Hirao Hajime , Kinjo Rei 
Published: April 2015

AbstractThe first metal‐free catalytic hydroboration of carbonyl derivatives is developed in which a catalytic amount of 1,3,2‐diazaphospholene effectively promotes a hydroboration reaction of aliphatic and aromatic aldehydes and ketones.
ChemInform Abstract: Efficient Desulfinative Cross‐Coupling of Heteroaromatic Sulfinates with Aryl Triflates in Environmentally Friendly Protic Solvents.
Authors: Forgione Pat , Mangel Daniel , Buonomano Cindy , Sevigny Stephane , Di Censo Gianna , Thevendran Gowsic 
Published: April 2015

AbstractAryl‐substituted heteroaromatics (III) are obtained under optimized conditions employing aqueous and alcoholic media without the use of base, additives or co‐catalysts.
ChemInform Abstract: The Chemoselective N‐Boc Protection of Amines in the Presence of Solid‐Supported Perchloric Acid as an Efficient and Reusable Solid Acid.
Authors: Khaligh Nader Ghaffari , Hazarkhani Hassan 
Published: April 2015

AbstractPoly(4‐vinylpyridinium) perchlorate is found to be an excellent catalyst for the chemoselective N‐Boc protection of various amines under neat reaction conditions.
ChemInform Abstract: Aerobic Palladium‐Catalyzed Dioxygenation of Alkenes Enabled by Catalytic Nitrite.
Authors: Wickens Zachary K. , Guzman Pablo E. , Grubbs Robert H. 
Published: April 2015

AbstractCatalytic nitrite is found to enable carbon‐oxygen bond‐forming reductive elimination from unstable alkyl palladium intermediates, providing dioxygenated products from alkenes.
ChemInform Abstract: Synthesis of Unsymmetrical, gem‐Disubstituted Bisamides.
Authors: Bode Jeffrey W. , Schaefer Gabriel , Leu Lukas 
Published: April 2015

AbstractKetone‐derived unsymmetrical, gem‐disubstituted bisamides (III) are obtained by the addition of Grignard reagents to N‐acyl isocyanates, generated in situ by Lossen rearrangement of corresponding hydroxamic acids (I).
ChemInform Abstract: Asymmetric Dearomatization of β‐Naphthols Through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid.
Authors: Wang Shou‐Guo , Yin Qin , Zhuo Chun‐Xiang , You Shu‐Li 
Published: April 2015

AbstractThis protocol provides facile access to functionalized β—naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity.
ChemInform Abstract: Enantiodivergent Synthesis of Wieland—Miescher Ketone Analogue Mediated by a Chiral Pyridinylmethylamine Derivative.
Authors: Inomata Kohei , Endo Yasuyuki , Honda Shota 
Published: April 2015

AbstractThe title compound is synthesized by the intramolecular aldol reaction of trione (I) mediated by a chiral pyridinylmethyl amine in the presence of trifluoroacetic acid.
ChemInform Abstract: Organocatalytic Enantioselective Approach to Spirocyclic Δβ,γ‐Butenolides.
Authors: Hejmanowska Joanna , Dziegielewski Marek , Kowalczyk Dorota , Albrecht Lukasz 
Published: April 2015

AbstractThe title compounds are prepared by a one‐pot procedure via [4+2]‐cycloaddition of 2,5‐hexadienals and 3‐arylmethylidene‐5‐aryl‐2,3‐dihydrofuran‐2‐ones using TDP as chiral catalyst followed by Ramirez olefination in moderate yields with moderate to good dia‐ and excellent enantioselectivities.
ChemInform Abstract: Graphite Oxide‐Promoted One‐Pot Synthesis and Oxidative Aromatization of Hantzsch 1,4‐Dihydropyridines.
Authors: Mirza‐Aghayan Maryam , Asadi Fatemeh , Boukherroub Rabah 
Published: April 2015

AbstractGraphite oxide is a readily available, inexpensive, mild, and efficient agent for the one‐pot synthesis of pyridine compounds (III) using a three‐component Hantzsch reaction.
ChemInform Abstract: A Convenient and Efficient Synthesis of 2‐(Het)arylthieno[3,2‐b]pyridin‐7(4H)‐ones and 2,3‐Di(het)arylthieno[3,2‐b]pyridin‐7(4H)‐ones.
Authors: Puvvala Srinu , Jadhav Vinod D. , Farooq Sheikh M. , Reddy C. Venkata Ramana , Machiraju Pavan Kumar 
Published: April 2015

AbstractThe synthesis of the starting compounds has been reported previously.
ChemInform Abstract: Facile Formation of β‐Hydroxyboronate Esters by a Cu‐Catalyzed Diboration/Matteson Homologation Sequence.
Authors: Moore Cameron M. , Medina Casey R. , Cannamela Peter C. , McIntosh Melissa L. , Ferber Carl J. , Roering Andrew J. , Clark Timothy B. 
Published: April 2015

AbstractThe synthetic utility of the method is demonstrated by the oxidation of one product to provide the protected diol (VI).
ChemInform Abstract: Fourfold Diels—Alder Reaction of Tetraethynylsilane.
Authors: Geyer Florian L. , Rode Alexander , Bunz Uwe H. F. 
Published: April 2015

AbstractA series of ethynylated silanes, including tetraethynylsilane, is treated with tetraphenylcyclopentadienone at 300°C under microwave irradiation to give the aromatized Diels—Alder adducts as sterically encumbered mini‐dendrimers with up to 20 benzene rings.
ChemInform Abstract: Synthesis of 1,2‐Dialkynyldisilanes Incorporated in 10‐Membered‐Ring System.
Authors: Tokitoh Norihiro , Mizuhata Yoshiyuki , Egawa Yasunobu , Sasamori Takahiro 
Published: April 2015

AbstractNovel 10‐membered‐cyclic silanes are obtained as trans‐ and cis‐isomers (V)/(VI) by reduction of a bis(dichloroethynylsilane) bridged by o‐xylylene (IV) using lithium naphthalenide.
ChemInform Abstract: n‐BuLi as a Highly Efficient Precatalyst for Hydrophosphonylation of Aldehydes and Unactivated Ketones.
Authors: Liu Chengwei , Zhang Yu , Qian Qinqin , Yuan Dan , Yao Yingming 
Published: April 2015

AbstractBuLi is shown to be an efficient catalyst for the hydrophosphonylation reaction of aldehydes and ketones.
ChemInform Abstract: A Convenient Approach to a Novel Group of Quaternary Amino Acids Containing a Geminal Bisphosphonate Moiety.
Authors: Dziegielewski Marek , Hejmanowska Joanna , Albrecht Lukasz 
Published: April 2015

AbstractAttempts upon an enantioselective version of the presented procedure using cinchona alkaloids and their derivatives as chiral catalysts provide the corresponding products with low enantiomeric excess.
ChemInform Abstract: Cochlearols A (I) and B (II), Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear that have Renoprotective Activities.
Authors: Dou Man , Di Lei , Zhou Li‐Li , Yan Yong‐Ming , Wang Xin‐Long , Zhou Feng‐Jiao , Yang Zhu‐Liang , Li Rong‐Tao , Hou Fan‐Fan , Cheng Yong‐Xian 
Published: April 2015

AbstractThe title compounds are isolated as their racemic mixtures.
ChemInform Abstract: A New Amaryllidaceae Alkaloid from the Bulbs of Lycoris radiata.
Authors: Lee Ji Young , Cha Mi‐Ran , Lee Ji Eun , Kim Jinhee , Cho Heeyeong , Park Woo Kyu , Choi Sang Un , Ryu Shi Yong 
Published: April 2015

Abstractisolation, structure elucidation and acetylcholinesterase inhibition of the new amaryllidaceae alkaloid, 6‐hydroxytazettine (I), and 17 related alkaloids
ChemInform Abstract: Two New Lycodine Alkaloids from Lycopodiastrum casuarinoides.
Authors: Wu Ji‐Chun , Wang Qiu‐Yue , Tao Ying‐Jiang , Jiang Jin‐He , Liu Ying , Huang Guo‐Li , Zhan Rui , Liu Bo , Chen Ye‐Gao 
Published: April 2015

Abstractisolation and structure determination of two new lycodine alkaloids, 11β‐methoxyhuperzine B (I) and 16‐oxohuperzidine (II) along with seven known compounds
ChemInform Abstract: The Asymmetric Total Synthesis of Cinbotolide: A Revision of the Original Structure.
Authors: Botubol Jose Manuel , Duran‐Pena Maria Jesus , Macias‐Sanchez Antonio J. , Hanson James R , Collado Isidro G. , Hernandez‐Galan Rosario 
Published: April 2015

AbstractThe originally assumed 11‐membered lactone structure for a Botrytis cinerea metabolite is revised to γ‐butyrolactone (I).
ChemInform Abstract: Chlorocatechelins A and B from Streptomyces sp.: New Siderophores Containing Chlorinated Catecholate Groups and an Acylguanidine Structure.
Authors: Kishimoto Shinji , Nishimura Shinichi , Hattori Akira , Tsujimoto Masafumi , Hatano Masaki , Igarashi Masayuki , Kakeya Hideaki 
Published: April 2015

AbstractThe iron(III)‐binding properties of (Ia) are investigated and the decomposition of (Ia) to (Ib) is discussed.
ChemInform Abstract: Improved and Large‐Scale Synthesis of 10‐Methyl‐aplog‐1, a Potential Lead for an Anticancer Drug.
Authors: Kikumori Masayuki , Yanagita Ryo C. , Irie Kazuhiro 
Published: April 2015

AbstractCompound (I) can be afforded in several hundreds of milligram with high purity by the presented approach in 23 steps from commercially available m‐hydroxycinnamic acid with an overall yield of 1.1%.
Meaning and Measurability of Single‐Ion Activities, the Thermodynamic Foundations of pH, and the Gibbs Free Energy for the Transfer of Ions between Dissimilar Materials
Authors: Rockwood Alan L. 
Published: April 2015

AbstractConsidering the relationship between concentration and vapor pressure (or the relationship between concentration and fugacity) single‐ion activity coefficients are definable in purely thermodynamic terms. The measurement process involves measuring a contact potential between a solution and an external electrode. Contact potentials are measurable by using thermodynamically reversible processes. Extrapolation of an equation to zero concentration and ionic strength enables determination of single‐ion activity coefficients. Single‐ion activities can be defined and measured without using any extra‐thermodynamic assumptions, concepts, or measurements. This method could serve as a gold standard for the validation of extra‐thermodynamic methods for determining single‐ion activities. Furthermore, it places the concept of pH on a thermodynamically solid foundation. Contact potential measurements can also be used to determine the Gibbs free energy for the transfer of ions between dissimilar materials.
Thermodynamics and Kinetics of Prenucleation Clusters, Classical and Non‐Classical Nucleation
Authors: Zahn Dirk 
Published: April 2015

AbstractRecent observations of prenucleation species and multi‐stage crystal nucleation processes challenge the long‐established view on the thermodynamics of crystal formation. Here, we review and generalize extensions to classical nucleation theory. Going beyond the conventional implementation as has been used for more than a century now, nucleation inhibitors, precursor clusters and non‐classical nucleation processes are rationalized as well by analogous concepts based on competing interface and bulk energy terms. This is illustrated by recent examples of species formed prior to/instead of crystal nucleation and multi‐step nucleation processes. Much of the discussed insights were obtained from molecular simulation using advanced sampling techniques, briefly summarized herein for both nucleation‐controlled and diffusion‐controlled aggregate formation.
Proportional fairness: more secrets revealed
Authors: Dalalah Doraid 
Published: April 2015

SummaryIn this paper, the resource allocation problem in a general network configuration is addressed. In particular, we will present a distributed solution algorithm in one the hand, followed by the exact set of equations that solves for (p,1)‐proportionally fair allocation in an attempt to express the network optimal rates in a closed form on the other hand. First, the problem is presented as an optimization model that maximizes the social utility of the network. A duality approach is used to solve the network model in a timely synchronized iterative manner. Next, the exact analytical variant of the model is presented showing its equivalence to the numerical solution. The analytical model relies on the pattern of bottlenecks inside the network, which can be found using a weighted progressive filling. Such a pattern will help in finding the exact analytical set of equations that solves for proportionally fair rates for any network configuration.Closed‐form solutions are now computed for different networks including well‐known configurations such as linear, grid, and cyclic networks. Different simulation experiments are conducted along with the solution of standard optimization solvers. The results of the simulation, the solvers, and the analytical solutions coincide and present the same allocation. Copyright © 2015 John Wiley & Sons, Ltd.