bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a Fatigue Self-Management Program for People with Multiple Sclerosis
Authors: Mulligan Hilda , Wilkinson Amanda , Barclay Amelia , Whiting Hayley , Heynike Christelle , Snowdon Jessie 
Published: November 2015

Background: Fatigue is one of the most common and debilitating symptoms of multiple sclerosis (MS). The program “Minimise Fatigue, Maximise Life: Creating Balance with Multiple Sclerosis” (MFML) was created in New Zealand because of the lack of a fatigue management program for people with MS in that country. This program aims to empower individuals with MS to manage their own symptoms of fatigue. The objective of this study was to evaluate the MFML fatigue self-management program.
Methods: Self-report questionnaires were used to measure impact of fatigue (5-item Modified Fatigue Impact Scale), self-efficacy (MS Self-efficacy Scale), and quality of life (12-item Short Form Health Status Survey [SF-12]) 1 month before (T1), at commencement of (T2) (to investigate the stability of questionnaire scores before the intervention), and at the end of (T3) the 6-week group-based program. Increased self-efficacy and quality of life scores and a decrease in reported impact of fatigue were the anticipated primary outcomes, with participants acting as their own controls.
Results: Twenty-five women (aged 37–63 years) participated. Stability of scores for all the questionnaires was evidenced between T1 and T2. After the intervention (T3), scores showed a significant improvement in self-efficacy and impact of fatigue, with large effect sizes, but no change in either the physical or mental component summary of the SF-12.
Conclusions: Despite the small sample size, this study showed an organized approach to the management of fatigue for people living with MS, and its outcomes demonstrated benefits for participants.
NmF2 enhancement during ionospheric F2 region nighttime: A statistical analysis based on COSMIC observations during the 2007–2009 solar minimum
Authors: Chen Yiding , Liu Libo , Le Huijun , Wan Weixing , Zhang Hui 
Published: October 2015

AbstractIn this paper the global features of NmF2 enhancement occurring during ionospheric F2 region nighttime (the period when the sunlight is occulted by the Earth in the altitudinal range of ionospheric F2 region) and lasting for more than 2 h were investigated based on Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) measurements during the 2007–2009 solar minimum. This nighttime enhancement of NmF2 mainly appears at the latitudes with dips larger than 45° in the winter hemisphere in solstice seasons. The magnitude of NmF2 enhancement reaches latitudinal maxima (minima) at the geomagnetic latitudes of about 40°–50° (60°–70°), with larger magnitudes in the northern winter hemisphere than in the southern winter hemisphere. The longitudinal variation of nighttime enhancement is also evident; especially the magnitude of NmF2 enhancement shows a significant longitudinal modulation in the southern winter hemisphere. The controlling factors of the spatial variations of NmF2 nighttime enhancement were analyzed. The longitudinal variation of NmF2 nighttime enhancement is suggested to be related to the longitudinal differences in background NmF2, thermospheric density, and interhemispheric plasma transport, and the latitudinal variation of NmF2 nighttime enhancement is possibly related to the latitudinal variations of geomagnetic inclination and the plasma storage in the topside ionosphere and the plasmasphere. The configuration of the geomagnetic field plays an important role in the longitudinal and latitudinal variations of NmF2 nighttime enhancement.
Low nanopore connectivity limits gas production in Barnett formation
Authors: Hu Qinhong , Ewing Robert P. , Rowe Harold D. 
Published: October 2015

AbstractGas‐producing wells in the Barnett Formation show a steep decline from initial production rates, even within the first year, and only 12–30% of the estimated gas in place is recovered. The underlying causes of these production constraints are not well understood. The rate‐limiting step in gas production is likely diffusive transport from matrix storage to the stimulated fracture network. Transport through a porous material such as shale is controlled by both geometry (e.g., pore size distribution) and topology (e.g., pore connectivity). Through an integrated experimental and theoretical approach, this work finds that the Barnett Formation has sparsely connected pores. Evidence of low pore connectivity includes the sparse and heterogeneous presence of trace levels of diffusing solutes beyond a few millimeters from a sample edge, the anomalous behavior of spontaneous water imbibition, the steep decline in edge‐accessible porosity observed in tracer concentrations following vacuum saturation, the low (about 0.2–0.4% by volume) level presence of Wood's metal alloy when injected at 600 MPa pressure, and high tortuosity from mercury injection capillary pressure. Results are consistent with an interpretation of pore connectivity based on percolation theory. Low pore connectivity of shale matrix limits its mass transfer interaction with the stimulated fracture network from hydraulic fracturing and serves as an important underlying cause for steep declines in gas production rates and a low overall recovery rate.
Seismic hydraulic fracture migration originated by successive deep magma pulses: The 2011–2013 seismic series associated to the volcanic activity of El Hierro Island
Authors: Díaz‐Moreno A. , Ibáñez J. M. , De Angelis S. , García‐Yeguas A. , Prudencio J. , Morales J. , Tuvè T. , García L. 
Published: October 2015

AbstractIn this manuscript we present a new interpretation of the seismic series that accompanied eruptive activity off the coast of El Hierro, Canary Islands, during 2011–2013. We estimated temporal variations of the Gutenberg‐Richter b value throughout the period of analysis, and performed high‐precision relocations of the preeruptive and syneruptive seismicity using a realistic 3‐D velocity model. Our results suggest that eruptive activity and the accompanying seismicity were caused by repeated injections of magma from the mantle into the lower crust. These magma pulses occurred within a small and well‐defined volume resulting in the emplacement of fresh magma along the crust‐mantle boundary underneath El Hierro. We analyzed the distribution of earthquake hypocenters in time and space in order to assess seismic diffusivity in the lower crust. Our results suggest that very high earthquake rates underneath El Hierro represent the response of a stable lower crust to stress perturbations with pulsatory character, linked to the injection of magma from the mantle. Magma input from depth caused large stress perturbations to propagate into the lower crust generating energetic seismic swarms. The absence of any preferential alignment in the spatial pattern of seismicity reinforces our hypothesis that stress perturbation and related seismicity, had diffusive character. We conclude that the temporal and spatial evolution of seismicity was neither tracking the path of magma migration nor it defines the boundaries of magma storage volumes such as a midcrustal sill. Our conceptual model considers pulsatory magma injection from the upper mantle and its propagation along the Moho. We suggest, within this framework, that the spatial and temporal distributions of earthquake hypocenters reflect hydraulic fracturing processes associated with stress propagation due to magma movement.
Downdip variations in seismic reflection character: Implications for fault structure and seismogenic behavior in the Alaska subduction zone
Authors: Li Jiyao , Shillington Donna J. , Bécel Anne , Nedimović Mladen R. , Webb Spahr C. , Saffer Demian M. , Keranen Katie M. , Kuehn Harold 
Published: October 2015

AbstractSeismic reflection data collected offshore of Alaska Peninsula across the western edge of the Semidi segment show distinctive variations in reflection characteristics of the megathrust fault with depth, suggesting changes in structure that may relate to seismic behavior. From the trench to ~40 km landward, two parallel reflections are observed, which we interpret as the top and bottom of the subducted sediment section. From ~50 to 95 km from the trench, the plate interface appears as a thin (<400 ms) reflection band. Deeper and farther landward, the plate interface transitions to a thicker (1–1.5 s) package of reflections, where it appears to intersect the fore‐arc mantle wedge based on our preferred interpretation of the continental Moho. Synthetic waveform modeling suggests that the thin reflection band is best explained by a single ~100 to 250 m thick low‐velocity zone, whereas the thick reflection band requires a 3 to 5 km thick zone of thin layers. The thin reflection band is located at the center of the 1938 Mw 8.2 Semidi earthquake rupture zone that now experiences little interplate seismicity. The thick reflection band starts at the downdip edge of the rupture zone, correlates with a dipping band of seismicity, and projects to the location of tremor at greater depth. We interpret the thin reflection band as a compacted sediment layer and/or localized shear zone. The thick reflection band could be caused by a wide deformation zone with branching faults and/or fluid‐rich layers, representing a broad transition from stick‐slip sliding to slow slip and tremor.
Optical properties of melting first‐year Arctic sea ice
Authors: Light Bonnie , Perovich Donald K. , Webster Melinda A. , Polashenski Christopher , Dadic Ruzica 
Published: October 2015

AbstractThe albedo and transmittance of melting, first‐year Arctic sea ice were measured during two cruises of the Impacts of Climate on the Eco‐Systems and Chemistry of the Arctic Pacific Environment (ICESCAPE) project during the summers of 2010 and 2011. Spectral measurements were made for both bare and ponded ice types at a total of 19 ice stations in the Chukchi and Beaufort Seas. These data, along with irradiance profiles taken within boreholes, laboratory measurements of the optical properties of core samples, ice physical property observations, and radiative transfer model simulations are employed to describe representative optical properties for melting first‐year Arctic sea ice. Ponded ice was found to transmit roughly 4.4 times more total energy into the ocean, relative to nearby bare ice. The ubiquitous surface‐scattering layer and drained layer present on bare, melting sea ice are responsible for its relatively high albedo and relatively low transmittance. Light transmittance through ponded ice depends on the physical thickness of the ice and the magnitude of the scattering coefficient in the ice interior. Bare ice reflects nearly three‐quarters of the incident sunlight, enhancing its resiliency to absorption by solar insolation. In contrast, ponded ice absorbs or transmits to the ocean more than three‐quarters of the incident sunlight. Characterization of the heat balance of a summertime ice cover is largely dictated by its pond coverage, and light transmittance through ponded ice shows strong contrast between first‐year and multiyear Arctic ice covers.
Sensitivity of MJO propagation to a robust positive Indian Ocean dipole event in the superparameterized CAM
Authors: Benedict James J. , Pritchard Michael S. , Collins William D. 
Published: October 2015

AbstractThe superparameterized Community Atmosphere Model (SPCAM) is used to investigate the impact and geographic sensitivity of positive Indian Ocean Dipole (+IOD) sea‐surface temperatures (SSTs) on Madden‐Julian oscillation (MJO) propagation. The goal is to clarify potentially appreciable +IOD effects on MJO dynamics detected in prior studies by using a global model with explicit convection representation. Prescribed climatological October SSTs and variants of the SST distribution from October 2006, a +IOD event, force the model. Modest MJO convection weakening over the Maritime Continent occurs when either climatological SSTs, or +IOD SST anomalies restricted to the Indian Ocean, are applied. However, severe MJO weakening occurs when either +IOD SST anomalies are applied globally or restricted to the equatorial Pacific. MJO disruption is associated with time‐mean changes in the zonal wind profile and lower moist static energy (MSE) in subsiding air masses imported from the Subtropics by Rossby‐like gyres. On intraseasonal scales, MJO disruption arises from significantly smaller MSE accumulation, weaker meridional advective moistening, and overactive submonthly eddies that mix drier subtropical air into the path of MJO convection. These results (1) demonstrate that SPCAM reproduces observed time‐mean and intraseasonal changes during +IOD episodes, (2) reaffirm the role that submonthly eddies play in MJO propagation and show that such multiscale interactions are sensitive to interannual SST states, and (3) suggest that boreal fall +IOD SSTs local to the Indian Ocean have a significantly smaller impact on Maritime Continent MJO propagation compared to contemporaneous Pacific SST anomalies which, for October 2006, resemble El Niño‐like conditions.
Preparation of glucose‐sensitive and fluorescence micelles via a combination of photoinitiated polymerization and chemoenzymatic transesterification for the controlled release of insulin
Authors: Du Xiangxiang , Jiang Guohua , Li Lei , Yang Wentong , Chen Hua , Liu Yongkun , Huang Qin 
Published: October 2015

ABSTRACTGlucose‐sensitive and fluorescence copolymer micelles were designed and prepared via a combination of photoinitiated polymerization and enzymatic transesterification. The water‐soluble photoinitiator and emulsifier 2‐oxooctanoic acid self‐polymerized dimer molecules under UV irradiation were characterized by mass spectrometry. The fluorescence dye (9‐anthracene alcohol) and biocompatible hydrophilic chains [poly(ethylene glycol)] were introduced to the polymer chains during the photopolymerization and enzymatic transesterification processes. The as‐prepared copolymers were confirmed by1H‐NMR spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, and dynamic light scattering. The resulting copolymers exhibited excellent glucose sensitivity and stability against protein. The optical fluorescence properties of the copolymer micelles were investigated with fluorescence spectrophotometry, fluorescence microscopy, and confocal laser scanning microscopy. Because of the amphiphilic feature, the micelles could be self‐assembled and used to load insulin. The controlled release of insulin was evaluated and was triggered by glucosein vitro. This study provided a new strategy for fabricating functional carriers as self‐regulated insulin‐release systems. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2016,133, 43026.
Synthesis of metal‐free poly(p‐dioxanone) by phosphazene base catalyzed ring‐opening polymerization
Authors: Yang Hongjun , Bai Tao , Xue Xiaoqiang , Huang Wenyan , Chen Jianhai , Jiang Bibiao 
Published: October 2015

ABSTRACTPoly(p‐dioxanone) (PPDO) has received significant attention due to its good biocompatibility and fast biodegradation profiles. In addition, PPDO is a polymer with high potential in biomedical applications. However, the conventional syntheses of PPDO via the ring‐opening polymerization (ROP) of p‐dioxanone (PDO) often use a metallic catalyst, which significantly limits its biorelated applications. This investigation was focused on the synthesis of metal‐free PPDO by using phosphazene base t‐BuP4 as the catalyst. The effects of the reaction conditions including temperature, reaction time, initiators, and feed molar ratios were studied in detail by nuclear magnetic resonance spectroscopy, viscosimetry, differential scanning calorimetry, and thermogravimetric analysis. The results showed that t‐BuP4 exhibited especially high activity in catalyzing alcohol or aniline to initiate the ROP of PDO, consequently resulting in metal‐free PPDOs. The polymerization was optimum at a reaction temperature of approximately 100°C and 88.7% of PDO was consumed. The viscosity–average molecular weights of the resulting polymer reached as high as 2.09 × 104 g/mol. The molar ratios of [PDO]/[t‐BuP4] also had an obvious effect on both the polymerization and the resulting polymer. Increasing [PDO]/[t‐BuP4] ratios facilitated the molecular weight growth, whereas the conversions of PDO significantly decreased. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43030.
Relevance of the acid–base approach in prediction of adhesion properties in two‐component injection moulding
Authors: Kraus Eduard , Horvat Sonja , Deubel Christian , Staudigel Christian , Baudrit Benjamin , Heidemeyer Peter , Bastian Martin , Starostina Irina , Stoyanov Oleg 
Published: October 2015

ABSTRACTWe demonstrate the use of innovative wetting method in prediction of the adhesion properties of biobased polymers for two‐component injection moulding, taking into account the acid–base surface properties of joined materials. The measurements were carried out in accordance with modified Berger method by calculation of the difference in shortened acidity parameter ΔDshort between hard and soft component. Correlation factors up to 0.99 were observed between ΔDshort and peel force. In comparison to results obtained by conventional wetting methods, high potential for the selection of components with high interface adhesion and for prediction of the functionality by the acid–base approach was demonstrated. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43048.
Preparation and characterization of inherently heat‐sealable polyimides with high glass transition temperatures
Authors: Ni Hongjiang , Liu Jingang , Yang Shiyong 
Published: October 2015

ABSTRACTA series of inherently heat‐sealable copolyimides (CPIs) with high glass transition temperatures were synthesized from 2,3,3′,4′‐oxydiphthalic anhydride (aODPA) and bicomponent diamines, 4,4′‐oxydianiline (ODA) and para‐phenylenediamine (PDA). The PI chain rigidity was manipulated by the regulation of the diamine ratio, and its effects on the heat sealability and thermal resistance of the derived CPI films were investigated in detail. The results show that these films are in possession of both good heat sealability and thermal resistance due to the synergetic effect of the asymmetry of aODPA and the rigidity of PDA. It is also found that there exists one critical PDA content that distinguishes the heat‐sealing behaviors of the CPI films, and the relevant mechanism was established. Especially for CPI‐5, the heat‐sealing strength is up to 350 N m−1 simultaneously with a relatively high Tg of 310°C. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43058.
Modulating stability and mechanical properties of silica–gelatin hybrid by incorporating epoxy‐terminated polydimethylsiloxane oligomer
Authors: Han Xiaona , Du Weining , Li Yupeng , Li Zhengjun , Li Lixin 
Published: October 2015

ABSTRACTSilica‐gelatin hybrids, particularly GT‐G hybrids prepared by crosslinking gelatin (G) with γ‐glycidoxypropyltrimethoxysilane (GT), have attracted much attention in tissue engineering for diverse applications in hard or soft tissue regeneration; however, scaffolds with tunable properties are needed to meet specific requirements. In this work, a silica‐gelatin hybrid (ES/GT‐G) was synthesized by incorporating epoxy‐terminated polydimethylsiloxane oligomer (ES) to modulate the properties of GT‐G hybrid. The ES/GT‐G hybrid sponge presented a 3D network structure with porosity 86.4% ± 0.9%, determined by the liquid displacement method, and average pore size 340 ± 36 μm, determined by SEM observation. Compared with GT‐G hybrid material, the prepared ES/GT‐G hybrid wet film showed a decrease of tensile strength from 2.79 ± 0.04 MPa to 1.87 ± 0.12 MPa, with an increase of elongation at break from 19.96 ± 0.66% to 29.86 ± 0.87%, and the ES/GT‐G hybrid sponge exhibited a decline of compressive yield strength from 1.21 ± 0.04 MPa to 0.72 ± 0.06 MPa, based on the tensile and compression tests respectively. The introduction of ES enhanced the thermal denaturing temperature of GT‐G by 5°C as determined by a DSC study, and increased in vitro biodegradation slightly, without significantly changing surface wettability and swelling behavior. These findings suggest that silica‐gelatin hybrids with tunable properties are promising for applications from hard to soft tissue regeneration. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43059.
Effect of layered silicates on fibril formation and properties of PCL/PLA microfibrillar composites
Authors: Kelnar Ivan , Fortelný Ivan , Kaprálková Ludmila , Kratochvíl Jaroslav , Angelov Borislav , Nevoralová Martina 
Published: October 2015

ABSTRACTThe study deals with improvement of poly(ɛ‐caprolactone) (PCL) parameters by in situ forming of poly(lactic acid) (PLA) fibrils. This structure is achieved by preparation of the melt‐drawn microfibrillar composite (MFC) from the PCL/PLA 80/20 blend containing the organophilized montmorillonite (oMMT) added using various mixing protocols. Improved mechanical behavior corresponds to the micron‐sized fibrils formation and reinforcement of both polymer components by oMMT, and to increased crystalline phase content in the fibrillar PLA phase. Effective melt drawing is only possible after the rheological parameters of the polymer components have been modified by oMMT where the clay addition method and content are of primary importance. From the results obtained, it follows that the role of oMMT in MFC is quite complex, numerous clay‐induced effects may be contradictory and must be harmonized to achieve PCL‐based biodegradable MFCs with improved parameters. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43061.
Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem‐like cells and identifies additional targets for radiosensitization
Authors: Rath Barbara H. , Wahba Amy , Camphausen Kevin , Tofilon Philip J. 
Published: October 2015

AbstractToward developing a model system for investigating the role of the microenvironment in the radioresistance of glioblastoma (GBM), human glioblastoma stem‐like cells (GSCs) were grown in coculture with human astrocytes. Using a trans‐well assay, survival analyses showed that astrocytes significantly decreased the radiosensitivity of GSCs compared to standard culture conditions. In addition, when irradiated in coculture, the initial level of radiation‐induced γH2AX foci in GSCs was reduced and foci dispersal was enhanced suggesting that the presence of astrocytes influenced the induction and repair of DNA double‐strand breaks. These data indicate that astrocytes can decrease the radiosensitivity of GSCs in vitro via a paracrine‐based mechanism and further support a role for the microenvironment as a determinant of GBM radioresponse. Chemokine profiling of coculture media identified a number of bioactive molecules not present under standard culture conditions. The gene expression profiles of GSCs grown in coculture were significantly different as compared to GSCs grown alone. These analyses were consistent with an astrocyte‐mediated modification in GSC phenotype and, moreover, suggested a number of potential targets for GSC radiosensitization that were unique to coculture conditions. Along these lines, STAT3 was activated in GSCs grown with astrocytes; the JAK/STAT3 inhibitor WP1066 enhanced the radiosensitivity of GSCs under coculture conditions and when grown as orthotopic xenografts. Further, this coculture system may also provide an approach for identifying additional targets for GBM radiosensitization.