bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomised trial comparing a short and a standard-length metaphyseal engaging cementless femoral stem using radiostereometric analysis
Authors: McCalden R. W. , Korczak A. , Somerville L. , Yuan X. , Naudie D. D. 
Published: May 2015

This was a randomised controlled trial studying the safety of a new short metaphyseal fixation (SMF) stem. We hypothesised that it would have similar early clinical results and micromovement to those of a standard-length tapered Synergy metaphyseal fixation stem. Using radiostereometric analysis (RSA) we compared the two stems in 43 patients. A short metaphyseal fixation stem was used in 22 patients and a Synergy stem in 21 patients. No difference was found in the clinical outcomes pre- or post-operatively between groups. RSA showed no significant differences two years post-operatively in mean micromovement between the two stems (except for varus/valgus tilt at p = 0.05) (subsidence 0.94 mm (sd 1.71) vs 0.32 mm (sd 0.45), p = 0.66; rotation 0.96° (sd 1.49) vs 1.41° (sd 2.95), p = 0.88; and total migration 1.09 mm (sd 1.74) vs 0.73 mm (sd 0.72), p = 0.51). A few stems (four SMF and three Synergy) had initial migration > 1.0 mm but stabilised by three to six months, with the exception of one SMF stem which required revision three years post-operatively. For most stems, total micromovement was very low at two years (subsidence < 0.5 mm, rotation < 1.0°, total migration < 0.5 mm), which was consistent with osseous ingrowth. The small sample makes it difficult to confirm the universal applicability of or elucidate the potential contraindications to the use of this particular new design of stem.Cite this article: Bone Joint J 2015; 97-B:595–602.
Psychic vampirism in contemporary psychoanalysis: Issues of pathological identification and sadomasochistic perversion
Authors: Yates Sheena 
Published: May 2015

Abstract
In this article, I consider the use of the metaphorics of vampirism in contemporary psychoanalytic theory. I examine the concept of psychic vampirism as a clinical phenomenon as evinced in two case studies and argue that psychic vampirism includes a sadomasochistic perversion and a specific identification with a narcissistic (m)other that leads to a general manner of identifying that is in itself pathological. Further, I argue that in the psychoanalytic clinical situation a psychic vampiric transference may manifest with either masochism or sadism predominating. I also demonstrate the pertinence of the literary vampire, via Anne Rice’s Interview with a Vampire (1976), to this clinical development. Finally, I suggest that psychic vampirism is likely to become more salient clinically, given the vampire’s current cultural popularity.
Well-posedness of the second-order linear singular Dirichlet problem
Authors: Lomtatidze Alexander , Opluštil Zdeněk 
Published: May 2015

Abstract
Conditions guaranteeing well-posedness of the problem

u

'
'

=

p
0

(
t
)

u
+

q
0

(
t
)

${u^{\prime \prime }=p_0(t)u+q_0(t)}$

,

u
(
a
)
=
0

${u(a)=0}$

,

u
(
b
)
=
0

${u(b)=0}$

,
are established. Here

p
0

,

q
0

:

]
a
,
b
[

→
ℝ

${p_0,q_0\colon ]a,b[\rightarrow \mathbb {R}}$

are locally
Lebesgue integrable functions and may have singularities at

t
=
a

${t=a}$

and

t
=
b

${t=b}$

.
The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki-Miyaura cross-coupling reactions
Authors: Brinkley Kendra W. , Burkholder Michael , Siamaki Ali R. , Belecki Katherine , Gupton B. Frank 
Published: May 2015

AbstractAn efficient, sustainable, and continuous method for the preparation of graphene supported palladium nanoparticles (Pd/G) has been developed using microwave irradiation as a heating source for the metal deposition process. The Pd/G produced from this method was effective in Suzuki-Miyaura cross-coupling reactions with a broad range of substrates. When incorporated into a packed bed flow reactor, this ligand free catalyst system continued to demonstrate high reaction conversions with limited catalyst leaching in the reaction mixture (347 ppb palladium).
Regularity theorems for harmonic functions
Authors: Ganenkova Ekaterina G. , Starkov Victor V. 
Published: May 2015

Abstract
The regularity theorem is a result stating that functions which have extremal growth or decrease in the given class display a regular behaviour. Such theorems for linearly invariant families of analytic functions are well known. We prove regularity theorems for some classes of harmonic functions. Many presented statements are new even in the analytic case.
Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young
Authors: Østoft Signe Harring , Bagger Jonatan Ising , Hansen Torben , Hartmann Bolette , Pedersen Oluf , Holst Jens Juul , Knop Filip Krag , Vilsbøll Tina 
Published: May 2015

ObjectiveThe role of the incretin hormones in the pathophysiology of maturity onset diabetes of the young (MODY) is unclear.DesignWe studied the postprandial plasma responses of glucagon, incretin hormones (glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP)) and dipeptidyl-peptidase 4 (DPP4) enzymatic activity in patients with glucokinase (GCK) diabetes (MODY2) and hepatocyte nuclear factor 1α (HNF1A) diabetes (MODY3) as well as in matched healthy individuals (CTRLs).Subjects and methodsTen patients with MODY2 (mean age±s.e.m.43±5 years; BMI 24±2 kg/m2; fasting plasma glucose (FPG) 7.1±0.3 mmol/l: HbA1c 6.6±0.2%), ten patients with MODY3 (age 31±3 years; BMI 24±1 kg/m2; FPG 8.9±0.8 mmol/l; HbA1c 7.0±0.3%) and ten CTRLs (age 40±5 years; BMI 24±1 kg/m2; FPG 5.1±0.1 mmol/l; HbA1c 5.3±0.1%) were examined with a liquid test meal.ResultsAll of the groups exhibited similar baseline values of glucagon (MODY2: 7±1 pmol/l; MODY3: 6±1 pmol/l; CTRLs: 8±2 pmol/l,P=0.787), but patients with MODY3 exhibited postprandial hyperglucagonaemia (area under the curve (AUC) 838±108 min×pmol/l) as compared to CTRLs (182±176 min×pmol/l,P=0.005) and tended to have a greater response than did patients with MODY2 (410±154 min×pmol/l,P=0.063). Similar peak concentrations and AUCs for plasma GIP and plasma GLP1 were observed across the groups. Increased fasting DPP4 activity was seen in patients with MODY3 (17.7±1.2 mU/ml) vs CTRLs (13.6±0.8 mU/ml,P=0.011), but the amount of activity was similar to that in patients with MODY2 (15.0±0.7 mU/ml,P=0.133).ConclusionThe pathophysiology of MODY3 includes exaggerated postprandial glucagon responses and increased fasting DPP4 enzymatic activity but normal postprandial incretin responses both in patients with MODY2 and in patients with MODY3.
Stress and Phase Engineered ZrO2/Ge for High-k Dielectric Applications
Authors: Achari Narayan K. V. L.V. , Banerjee Amiya , Raghavan Srinivasan 
Published: May 2015

ABSTRACTZrO2/Ge is potential high-k dielectric candidate to replace silicon based devices. Controlling stress in zirconia film and stabilizing high dielectric constant phase is crucial for high-k application. A precise control of stress and phase selectivity in high-k thin films is demonstrated. Thin films of ZrO2 were grown by reactive sputter deposition. Wide range of growth stress in thin films from -0.3 to -2.8 GPa can be tuned by growth rate control. Adatom incorporation into grain boundary was the dominant source of observed stress. Phase selectivity in zirconia was achieved by tuning growth parameters.
Porphyromonas gingivalis Suppresses Differentiation and Increases Apoptosis of Osteoblasts From New Zealand Obese Mice
Authors: Dittmann Cora , Doueiri Salim , Kluge Reinhart , Dommisch Henrik , Gaber Timo , Pischon Nicole 
Published: May 2015

Background: Metabolic syndrome (MetS), a complex cluster of risk factors for chronic diseases such as cardiovascular disease, is observed to be increasingly associated with periodontal disease. However, the fundamental contribution of periodontal bacteria to periodontal bone loss in patients with MetS remains unclear. The aim of the present study is to analyze the effect of Porphyromonas gingivalis on differentiation of primary osteoblasts from New Zealand obese (NZO) mice, a model for MetS, compared with C57 Black 6 JAX (C57BL/6J) mice osteoblasts.Methods: Primary calvarial osteoblasts, isolated from 3‐day‐old NZO and control C57BL/6J mice, were stimulated with P. gingivalis. Proliferation was quantified by 5‐bromo‐2′‐deoxyuridine incorporation. Cell cycle and early and late apoptosis were measured by flow cytometry. Gene expression was determined by real‐time polymerase chain reaction (RT‐PCR).Results: Twelve hours after P. gingivalis stimulation, NZO osteoblasts showed significantly decreased proliferation (P ≤0.01) with increased G2 cell cycle phase compared with normal osteoblasts. Flow cytometry analysis demonstrated significant (P ≤0.01) increase of early apoptotic cells (annexin V positive) and late apoptosis (caspase 3 activity) in NZO cells compared with control cells at 3 and 6 hours after stimulation. No significant lactate dehydrogenase release was found after P. gingivalis stimulation. RT‐PCR data showed significantly suppressed expression (P ≤0.01) of collagen 1, osteocalcin, and Runt‐related transcription factor 2 in NZO cells compared with normal osteoblasts.Conclusions: The present data demonstrate that P. gingivalis downregulates proliferation and promotes apoptosis in primary NZO osteoblasts, unlike C57BL/6J osteoblasts. Also, suppressed osteoblastic marker expression in NZO cells may contribute to pathogenesis of periodontitis, suggesting a similar process in patients with MetS.
Effect of Tillage System and Soil Conditioner Application on Soybean (Glycine Max (L.) Merrill.) and Its Crop Management Economic Indicators
Authors: Kováč Ladislav , Jakubová Jana , Šariková Danica 
Published: May 2015

Abstract
Experiments with soybean on heavy soils of East Slovak Lowlands were established in the years 2010–2012. The effect of mineral fertilisers and soil conditioner application on soybean’s yield using three tillage systems (minimum tillage (MT), conventional tillage (CT) and no tillage (NT)) was studied. Production costs and economic efficiency of crop management practices were evaluated. The influence of production year on soybean crop was significant in the order of 2011, 2010 and 2012. Statistical evaluation confirmed that the effects of CT and MT systems were more significant compared with NT system. No significant differences were found between the variants of the mineral fertiliser and conditioner application. Differences in the total cost of soybean cultivation, as measured between years, were not significant. Fertilisation variants with application of HUMAC agro and NPK generated the highest costs. On the other hand, the lowest costs were achieved at fertilisation variants with application of NPK alone. Comparing tillage variants, the CT system had the highest costs each year. Significant savings were achieved on MT and NT variants. During the experimental period, a profit was reached on all variants. Applying NPK alone, the highest profit was achieved in 2010 and 2012 using MT system and in 2011 with CT tillage. The variant b2 with PRP sol in the years 2010 and 2011 was the most profitable using NT system and in 2012 using MT. Variant with HUMAC agro was the most profitable in each year using MT. The lowest income threshold for zero profitability was calculated in 2012. Using CT farming techniques at NPK fertilisation variant b1 in 2012, the income threshold was 1.85 t/ha, at variant b2 PRP sol it was 2.10 t/ha and at variant b3 HUMAC agro it was 2.42 t/ha. At MT and NT systems, the income threshold values for zero profitability were lower.
Decision Tree Approach to Discovering Fraud in Leasing Agreements
Authors: Horvat Ivan , Pejić Bach Mirjana , Merkač Skok Marjana 
Published: May 2015

Abstract

Background: Fraud attempts create large losses for financing subjects in modern economies. At the same time, leasing agreements have become more and more popular as a means of financing objects such as machinery and vehicles, but are more vulnerable to fraud attempts. Objectives: The goal of the paper is to estimate the usability of the data mining approach in discovering fraud in leasing agreements. Methods/Approach: Real-world data from one Croatian leasing firm was used for creating tow models for fraud detection in leasing. The decision tree method was used for creating a classification model, and the CHAID algorithm was deployed. Results: The decision tree model has indicated that the object of the leasing agreement had the strongest impact on the probability of fraud. Conclusions: In order to enhance the probability of the developed model, it would be necessary to develop software that would enable automated, quick and transparent retrieval of data from the system, processing according to the rules and displaying the results in multiple categories.
Fostering Innovation in the National Systems: An Application to Spain
Authors: de Pablos Heredero Carmen , Bermejo Ruiz Jose Manuel 
Published: May 2015

Abstract

Background: The sharing of practices that enable the flow and the distribution of tacit knowledge and other ways of proprietary knowledge are essential requisites for promoting an innovation system. Objectives: In this paper a diagnosis of the Spanish Science and Technology System is offered by using the normalized protocol for responsible partnering proposed by EIRMA. Methods/Approach: The triple helix model has been used to identify the agents that take part in the system. The grounded theory has also been applied to analyse interactions and interviews with seven key agents in the system. Results: The lack of common objectives among the main partners in the system is the most important weakness; the New Acts developed in the last three years is a strength that allows the different agents of the system to share objectives. The economic crisis is a threat for the performance of research within the university context and becomes at the same time an opportunity to establish closer relationships. Conclusions: Universities, firms and governments must synchronise their work to accomplish a common objective: produce high levels of innovation that aim to enhance the competitiveness of the system.
Ultrasonographic measured optic nerve sheath diameter as an accurate and quick monitor for changes in intracranial pressure
Authors: Maissan Iscander M. , Dirven Perjan J. A. C. , Haitsma Iain K. , Hoeks Sanne E. , Gommers Diederik , Stolker Robert Jan 
Published: May 2015

OBJECT
Ultrasonographic measurement of the optic nerve sheath diameter (ONSD) is known to be an accurate monitor of elevated intracranial pressure (ICP). However, it is yet unknown whether fluctuations in ICP result in direct changes in ONSD. Therefore, the authors researched whether ONSD and ICP simultaneously change during tracheal manipulation in patients in the intensive care unit (ICU) who have suffered a traumatic brain injury (TBI).

MATERIALS
The authors included 18 ICP-monitored patients who had sustained TBI and were admitted to the ICU. They examined the optic nerve sheath by performing ultrasound before, during, and after tracheal manipulation, which is known to increase ICP. The correlation between ONSD and ICP measurements was determined, and the diagnostic performance of ONSD measurement was tested using receiver operating characteristic curve analysis.

RESULTS
In all patients ICP increased above 20 mm Hg during manipulation of the trachea, and this increase was directly associated with a dilation of the ONSD of > 5.0 mm. After tracheal manipulation stopped, ICP as well as ONSD decreased immediately to baseline levels. The correlation between ICP and ONSD was high (R2 = 0.80); at a cutoff of ≥ 5.0 mm ONSD, a sensitivity of 94%, a specificity of 98%, and an area under the curve of 0.99 (95% CI 0.97–1.00) for detecting elevated ICP were determined.

CONCLUSIONS
In patients who have sustained a TBI, ultrasonography of the ONSD is an accurate, simple, and rapid measurement for detecting elevated ICP as well as immediate changes in ICP. Therefore, it might be a useful tool to monitor ICP, especially in conditions in which invasive ICP monitoring is not available, such as at trauma scenes.
Incidence of seizures on continuous EEG monitoring following traumatic brain injury in children
Authors: O’Neill Brent R. , Handler Michael H. , Tong Suhong , Chapman Kevin E. 
Published: May 2015

OBJECT
Seizures may cause diagnostic confusion and be a source of metabolic stress after traumatic brain injury (TBI) in children. The incidence of electroencephalography (EEG)-confirmed seizures and of subclinical seizures in the pediatric population with TBI is not well known.

METHODS
A routine protocol for continuous EEG (cEEG) monitoring was initiated for all patients with moderate or severe TBI at a Level 1 pediatric trauma center. Over a 3.5-year period, all patients with TBI who underwent cEEG monitoring, both according to protocol and those with mild head injuries who underwent cEEG monitoring at the discretion of the treating team, were identified prospectively. Clinical data were collected and analyzed.

RESULTS
Over the study period, 594 children were admitted with TBI, and 144 of these children underwent cEEG monitoring. One hundred two (71%) of these 144 children had moderate or severe TBI. Abusive head trauma (AHT) was the most common mechanism of injury (65 patients, 45%) in children with cEEG monitoring. Seizures were identified on cEEG in 43 patients (30%). Forty (93%) of these 43 patients had subclinical seizures, including 17 (40%) with only subclinical seizures and 23 (53%) with both clinical and subclinical seizures. Fifty-three percent of patients with seizures experienced status epilepticus. Age less than 2.4 years and AHT mechanism were strongly correlated with presence of seizures (odds ratios 8.7 and 6.0, respectively). Those patients with only subclinical seizures had the same risk factors as the other groups. The presence of seizures did not correlate with discharge disposition but was correlated with longer hospital stay and intensive care unit stay.

CONCLUSIONS
Continuous EEG monitoring identifies a significant number of subclinical seizures acutely after TBI. Children younger than 2.4 years of age and victims of AHT are particularly vulnerable to subclinical seizures, and seizures in general. Continuous EEG monitoring allows for accurate diagnosis and timely treatment of posttraumatic seizures, and may mitigate secondary injury to the traumatized brain.
Topographical Irregularity and Keratoconic Findings in Five Siblings and their Parents
Authors: González-Méijome Jose M , Queiros Antonio , Diaz-Rey Alberto , Salgado-Borges José , Peixoto-de-Matos Sofia C , Soares Anabela 
Published: May 2015

ABSTRACT

Purpose
To report the clinical features of five siblings, four of them with positive diagnostic of keratoconus in different degrees of severity as well as their parents findings.

Materials and methods
Seven elements of the same family, five young siblings (2 males, 3 females), and their parents were screened for potential keratoconic signs. Topographic data from 60 normal eyes are also reported for comparison purposes. Complete ophthalmologic examination including biomicroscopic, topographic and refractive examination. Main outcome measures included biomicroscopic findings, refractive error and visual acuity, simulated keratometry, corneal eccentricity, indices of asymmetry and regularity.

Results
The more advanced case was present in the left eye of a male member, needing a rigid gas permeable lens to correct irregular astigmatism. Another brother also presented bilateral mild to moderate keratoconus with no apparent vision complaints. The third case diagnosed was one sister with history of monthly disposable soft toric lens to compensate a presumed initially regular astigmatism two years before. The remaining two cases being the older sister and one of the younger sisters presented the less noticeable signs, with confirmation of the pathology only in one of them and warranting a close follow- up of both due to the asymmetric corneal topography between both eyes as well as between the flatter superior and steeper inferior corneal areas.

Conclusion
This is the first reported case series involving diagnosis of keratoconus or atypical corneal topographies in several young siblings and their parents. Further evaluation of this and other cases with similar presentations might help to gain a deeper understanding on the potential genetic paths of keratoconus.

How to cite this article
González-Méijome JM, Peixoto-de- Matos SC, Soares A, Queirós A, Díaz-Rey A, Salgado-Borges J. Topographical Irregularity and Keratoconic Findings in Five Siblings and their Parents. Int J Kerat Ect Cor Dis 2014;3(3):130-135.
Response of Tomato Variety (Roma F) Yield to Different Mulch Materials and Staking in Kabba, Kogi State, Nigeria
Authors: S. K. Ogundare , I. J. Babatunde , O. O. Etukudo 
Published: May 2015

This experiment was carried out at student’s experimental field, Kabba College of Agriculture, Horticultural Section to investigate the response of tomato variety (Roma F) yield to different mulch materials and staking. A split plot experiment was laid out in a randomized complete block design (RCBD) with three replications to randomize the staking levels and mulch materials in the main and sub-plots, respectively. The experiment comprised of two staking levels, i.e. stick staking (SST) and no- stick staking (NST) and six mulch materials, i.e. black polyethylene, white polyethylene, maize straw, palm fronts, grasses and no mulch. The parameters taken on soil physical and chemical properties are soil moisture content (%), soil temperature (O C), soil pH, total nitrogen, available phosphorus and soil organic matter. Growth and yield parameters taken are as follows: average plant height, number of leaves, and number of fruits, stem girth, number of fruit per plant, fruit length, fruit diameter and yield per land area. Weeds were identified and their dry weights were measured. Data were collected from ten randomly selected plants in each plot. The data were statistically analyzed using GENSTAT. The analysis of variance (ANOVA) was performed to find out the significance of variation among the treatments while the significant difference between mean treatments were separated using Duncan’s multiple range test (DMRT) at 5% level of probability. The result obtained from this study indicated that mulch materials and stick staking affect significantly growth parameters of tomato, yield per plant and yield per land area. The result also, indicated that plot mulch with black polythene performance best in terms of growth and yield and also improved soil physical properties better than either white polythene or organic mulch in the study area. It is therefore recommended that black polyethylene should be used as mulch materials for tomato production. However, better and stable fruit yield of tomato could be obtained with the practice of mulching in combination with staking. It is recommended that mulching should be carried out together with staking for higher fruit yield and black polyethylene should be use as mulch material in the study area.