bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of ADRA2A and MTHFR gene polymorphisms with weight loss following antipsychotic switching to aripiprazole or ziprasidone
Authors: Roffeei Siti Norsyuhada , Reynolds Gavin P. , Zainal Nor Zuraida , Said Mas Ayu , Hatim Ahmad , Aida Syarinaz Ahmad , Mohamed Zahurin 
Published: November 2013

ObjectivesVarious genetic polymorphisms have been reported to be associated with antipsychotic‐induced weight gain. In this study, we aimed to determine whether risk polymorphisms in 12 candidate genes are associated with reduction in body mass index (BMI) of patients following switching of antipsychotics to aripiprazole or ziprasidone.MethodsWe recruited 115 schizophrenia patients with metabolic abnormalities and who have been on at least 1 year treatment with other antipsychotics; they were then switched to either aripiprazole or ziprasidone. They were genotyped, and their BMI monitored for 6 months.ResultsSignificant associations with reduction in BMI at 6 months following switching were found in two of these genes: with rs1800544 of the ADRA2A gene (CC + CG [−0.32 ± 1.41 kg/m2] vs GG [−1.04 ± 1.63 kg/m2], p = 0.013) and with rs1801131 of the MTHFR gene (AA [−0.36 ± 1.53] vs AC + CC [−1.07 ± 1.53], p = 0.015).ConclusionThe study data indicated that carriage of the ADRA2A rs1800544 GG genotype and the MTHFR rs1801131 C allele are associated with BMI reduction in this population following switching of antipsychotics to aripiprazole and ziprasidone. Copyright © 2013 John Wiley & Sons, Ltd.
WATER PRODUCTIVITY IN AGRICULTURE: CHALLENGES IN CONCEPTS, TERMS AND VALUES
Authors: Heydari Nader 
Published: November 2013

ABSTRACTThe concept of irrigation efficiency firstly defined by Israelsen in 1950. His definition remained fundamentally unchanged for more than 40 years, until from the 1970s the definition was moderately changed and modifications suggested. In recent decades the irrigation efficiency concept has gradually been replaced, both in the literature and in practice, with the introduction of crop water use efficiency (WUE) and later on with agricultural water productivity (WP).The issue of water management and interventions for its improvement runs across sectors. Different users and beneficiaries of water have legitimate interests in how water is allocated and used in their own as well as in competing sectors. The language and terminology of the debate is of importance to the value that analysis can add to knowledge. Even expert discussions can be confused by ambiguous terminology, while the water‐dependent sectors have no consistent terminology to distinguish between consumptive and non‐consumptive uses, or recoverable and non‐recoverable return flows.This paper provides an overview of the concepts of WP and its predecessors E and WUE, with a focus on WP for better planning and efficient use of water in the agricultural sector. Copyright © 2013 John Wiley & Sons, Ltd.
Communicating about opioids for chronic pain: A qualitative study of patient attributions and the influence of the patient–physician relationship
Authors: Matthias M.S. , Krebs E.E. , Bergman A.A. , Coffing J.M. , Bair M.J. 
Published: November 2013

AbstractBackgroundChronic pain poses numerous challenges for patients and providers, particularly when opioid treatment is discussed. Despite accounts of antagonistic patient–provider communication, little is known about how communication about opioids unfolds during clinic visits and, importantly, how the relationship history of a patient and physician shapes this communication. This study's objective was to advance understanding of communication about opioid treatment by recording primary care clinic visits and conducting in‐depth interviews with patients to gain insight into the patient–provider relationship and its influence on clinical communication.MethodsForty patients with chronic pain were audio recorded during their primary care clinic appointments and then interviewed about their pain care and relationships with their providers. Ten patients were excluded from analysis because pain was not discussed during the clinic visit.ResultsQualitative analysis revealed that patients responded in markedly different ways to similar physician treatment decisions about opioids. Some patients attributed limiting or denying opioids to physicians' distrust or lack of caring. Others attributed these limitations to acting out of genuine concern for patients' health. These attributions appeared to be shaped by features of the patient–physician relationship as described by patients. Results are discussed within the framework of attribution theory.ConclusionsUnderstanding how patients and providers discuss opioid treatment is critical for optimal pain treatment. Physicians might be able to improve communication by re‐framing treatment discussions about opioids around external factors, such as benefits and harms, and engaging in communication that fosters a strong therapeutic alliance and emphasizes concern for the patient.
Does magnetic resonance imaging predict future low back pain? A systematic review
Authors: Steffens D. , Hancock M.J. , Maher C.G. , Williams C. , Jensen T.S. , Latimer J. 
Published: November 2013

AbstractBackground and ObjectiveMagnetic resonance imaging (MRI) has the potential to identify pathology responsible for low back pain (LBP). However, the importance of findings on MRI remains controversial. We aimed to systematically review whether MRI findings of the lumbar spine predict future LBP in different samples with and without LBP.Databases and Data TreatmentMEDLINE, CINAHL and EMBASE databases were searched. Included were prospective cohort studies investigating the relationship between baseline MRI abnormalities of the lumbar spine and clinically important LBP outcome at follow‐up. We excluded cohorts with specific diseases as the cause of their LBP. Associations between MRI findings and LBP pain outcomes were extracted from eligible studies.ResultsA total of 12 studies met the inclusion criteria. Six studies presented data on participants with current LBP; one included a sample with no current LBP, three included a sample with no history of LBP and two included mixed samples. Due to small sample size, poor overall quality and the heterogeneity between studies in terms of participants, MRI findings and clinical outcomes investigated, it was not possible to pool findings. No consistent associations between MRI findings and outcomes were identified. Single studies reported significant associations for Modic changes type 1 with pain, disc degeneration with disability in samples with current LBP and disc herniation with pain in a mixed sample.ConclusionsThe limited number, heterogeneity and overall quality of the studies do not permit definite conclusions on the association of MRI findings of the lumbar spine with future LBP (PROSPERO: CRD42012002342).
Design of a compact triangular ring antenna and its array using log periodic property
Authors: Dadel Megha , Srivastava Shweta , Tiwary Kamala Pati 
Published: November 2013

ABSTRACTA microstrip triangular‐ring antenna structure designed using the log‐periodic principle has been proposed. The antenna elements and the feeding networks have been designed and the antenna simulations are done using Ansoft HFSS software. Shorting posts have been used at the center of the edges of the ring to adjust the shift in the resonant frequency. The simulated and tested results show that the ring antenna with three posts resonated at the same frequency as the triangular patch giving an enhanced gain and a size reduction of 81%. A log periodic array of three triangular rings is also designed and analyzed which gives a good frequency independent behavior in the frequency range of 6.6–11.6 GHz. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:41–46, 2014
Compact gradually variational stepped impedance resonator band‐stop filters
Authors: La Dong‐sheng , Huang Cai‐mei , Qiu Xin‐yun , Zhang Jin‐ling 
Published: November 2013

ABSTRACTThis article proposes a novel gradually variational stepped impedance hairpin resonator. Two band‐stop filters are proposed which are using the novel gradually variational stepped impedance hairpin resonator with defected ground structure or not. The filters have many remarkable advantages by using resonators, such as compact size, high selectivity, and simple structure. Good agreement between the simulated results and the measured results is achieved. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1–3, 2014
A fully differential injection‐locked frequency divider using CMOS technology
Authors: Park Bonghyuk , Jung Jaeho 
Published: November 2013

ABSTRACTA wide locking range and low phase noise injection‐locked frequency divider has been developed by CMOS 0.13‐μm technology. The proposed differential complementary injection‐locked frequency divider (CILFD) consists of five‐stage complementary inverter type connection. The differential input and output are implemented using auxiliary cross‐coupled inverters. The measurement results show a divide‐by‐5 division ratio and a locking range from 1.5 to 4.5 GHz with an input power lower than −5 dBm. The power consumption of CILFD is 1.0 mA from 1.4‐V power supply when it locked at 3‐GHz input signal. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:31–34, 2014
Fast prototype‐based design approach to highly miniaturized LTCC BPFS for WLAN/WIMAX dual‐mode applications
Authors: Huang Hui‐Hsiang , Horng Tzyy‐Sheng 
Published: November 2013

ABSTRACTA novel and fast prototype‐based approach is presented to design LTCC band pass filters (BPFs) using two reflection zeros for 2.4 GHz WLAN / 2.3 GHz worldwide interoperability for microwave access dual‐mode applications. The proposed approach derives quite compact formulas for synthesizing a filter prototype to meet the specification requirements in the passband insertion loss and stopband attenuation. From real‐time prototype simulation prediction, one can efficiently minimize the filter size under various electrical specifications. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:8–11, 2014
Novel micro‐scale sensors using WGMS within the modified add‐drop filter circuits
Authors: Yupapin Preecha P. , Sarapat Napatsakorn 
Published: November 2013

ABSTRACTWhispering gallery modes (WGMs) of light within a microscale modified add‐drop filter circuit has shown the interesting results, which can be formed for various sensing applications. The input waves (lights) into the sensing system can be a Gaussian pulse, which can induce the nonlinear coupling effects to the center ring by the two nonlinear side rings. By using the practical parameters, the simulation results are obtained by using the Optiwave program, which have shown the promising indication that the changes in phases between two WGMs can be used to perform the sensing applications, where the flow rate sensor, temperature sensors and medical sensors can be configured and used, which are discussed in details. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:14–17, 2014
Wideband circularly polarized square slot antenna with an annular patch
Authors: Shirzad Hamed , Shokri Majid , Amiri Zhaleh , Asiaban Somayeh , Virdee Bal 
Published: November 2013

ABSTRACTThis article presents a novel and compact circularly polarized square slot antenna (CPSSA) that operates across 2.93–11.43 GHz with an impedance bandwidth of 118% for VSWR ≤ 2. This makes the antenna feasible for UWB applications requiring high data rate transmission. The antenna with an annular radiation patch is fed through a coplanar waveguide and includes two inverted‐L shaped ground arms at two opposite corners of the slot to excite two orthogonal resonant modes for circular‐polarization (CP) radiation. A semicircular stub is embedded in the feed‐line to enhance its impedance bandwidth. The antenna exhibits CP bandwidth of 22.2% across 4.87–6.09 GHz, which incorporates the WLAN band. In addition, the antenna has a significantly smaller volume of 25 × 25 × 0.8 mm3. The measured and simulated results confirm the usefulness of the antenna for practical applications. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:229–233, 2014
High selective H‐plane TE dual mode cavity filter design by using nonresonating nodes
Authors: Boukari Bouraima , Vicente Carlos P. , Cogollos Santiago 
Published: November 2013

ABSTRACTThe design of H‐plane TE dual mode cavity filters using models containing nonresonating nodes is presented. From the models a coupling matrix is derived and decomposed into submatrices, each representing a subcircuit. The optimization and cascading of subcircuits represents a good starting point for the global optimization. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:161–166, 2014
Novel compact inverted U‐shaped directional coupler using parallel dual transmission lines technique
Authors: Ausordin Siti Fatimah , Rahim Sharul Kamal Abdul , Seman Norhudah , Dewan Raimi , Zaidel Dayang Norkhairunnisa Abang , Sa'ad BashirMuhammad , Jayaprakasam Suhanya 
Published: November 2013

ABSTRACTA novel compact design of a 3‐dB inverted U‐shaped directional coupler using dual parallel transmission lines on double layer substrates is presented in this article. Dual parallel transmission lines technique is used as a replacement of the conventional single transmission line. Hence, a smaller size and wider bandwidth of directional coupler is successfully achieved. The proposed coupler is highly adaptable to various microwave applications for microwave circuitry such as the Butler Matrix (BM) beamforming network. The reduction in size gives better flexibility for the integrated structure of BM system. The proposed 2.45‐GHz coupler successfully obtaining size reduction up to 40% compared to the rectangular multilayer directional coupler. In addition, 25% bandwidth performance was achieved. Dimension and S‐parameter performance comparison has been made between the proposed coupler which use dual parallel transmission lines technique in multilayer structure and rectangular multilayer coupler. The measurement results are in good agreement with simulated ones in terms return loss, coupling, through and isolation. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:251–256, 2014
Dual‐mode dual‐band bandpass filter with four transmission zeros using a capacitive mode coupling
Authors: Baik Jung‐Woo , Lee Tae‐Hak 
Published: November 2013

ABSTRACTA novel dual‐band bandpass filter (BPF) with dual‐mode operation is proposed that uses a compensative perturbation patch for generating four clear transmission zeros. The compensative perturbation serves as a function for changing the inductive coupling between the degenerate modes to the capacitive one in both passbands. This article deals with the filter design, analysis via the equivalent circuit of the proposed BPF, and the experimented results. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:248–251, 2014
Broadband UHF RFID tag antenna design matched with different RFID chips
Authors: Tang Zhi‐Jun , Wu Xiao‐Feng , Zhan Jie , Hu Shi‐Gang 
Published: November 2013

ABSTRACTA novel antenna structure with two crab‐shaped patches and a small microstrip dipole is proposed for ultra frequency radio frequency identification (RFID) tag design, which can be directly integrated in metallic plates or other objects. The feature of the design is that the tag antenna can operate effectively with different ultrahigh frequency (UHF) RFID chips, and the design of the conjugate impedance match of the RFID tag can be easily obtained. The important advantages of the antenna structure are that the tag does not have to be redesigned to work with different RFID chips. The antenna's size is 45 mm × 75 mm × 0.5 mm. The antenna achieves 200 MHz bandwidths, which covers worldwide UHF RFID bands (840–960 MHz). Furthermore, the proposed antenna obtains high gains and a good radiation pattern. The simulated and measured results are shown to be in good agreement with each other. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:55–57, 2014
Optically biased frequency doubler for noncontact harmonic transponders
Authors: Tahir Nazifa , Brooker Graham 
Published: November 2013

ABSTRACTAn optically biased Schottky diode frequency doubler has been fabricated and tested that shows an increase in conversion gain over unbiased variants under moderate and high illumination. The diode of the doubler is biased at the knee current by an optical bias that is a coupled photodiode instead of a conventional external bias by a power supply. This ensures the continuing operation of the diode under low radio frequency (RF) signal conditions and an operating point independent of incident RF power. The optically biased doubler can be used for developing noncontact harmonic transponders with improved radar cross section. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:233–236, 2014
Application of an oblique absorbing boundary condition in the finite element simulation of phased‐array antennas
Authors: Xue Ming‐Feng , Jin Jian‐Ming 
Published: November 2013

ABSTRACTThis article describes the application of an absorbing boundary condition for truncating finite element meshes in the analysis of phased‐array antennas. For a plane wave incident on a planar boundary at a certain specified angle, this boundary condition can be tuned to be reflectionless for all frequencies and polarizations. To demonstrate its application, this boundary condition is implemented in the dual‐primal finite‐element tearing and interconnecting method for simulation of large‐scale phased‐array antennas. A good performance is achieved in terms of accuracy and convergence of the numerical solution. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:178–184, 2014
Cardiovascular and mortality risk in elderly Medicare beneficiaries treated with olmesartan versus other angiotensin receptor blockers
Authors: Graham David J. , Zhou Esther H. , McKean Stephen , Levenson Mark , Calia Katlyn , Gelperin Kate , Ding Xiao , MaCurdy Thomas E. , Worrall Chris , Kelman Jeffrey A. 
Published: November 2013

ABSTRACTPurposeIn the randomized trial, Randomized Olmesartan and Diabetes Microalbuminuria Prevention, acute cardiovascular death was increased nearly fivefold in diabetic patients treated with high‐dose olmesartan, an angiotensin receptor blocker (ARB), compared with placebo.MethodsMedicare beneficiaries were entered into new‐user cohorts of olmesartan or other ARBs and followed on therapy for occurrence of acute myocardial infarction, stroke, or death. Analyses focused on specific subgroups defined by diabetes status, ARB dose, and duration of therapy. Hazard ratios (HR) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression, with other ARBs as reference.ResultsA total of 158 054 olmesartan and 724 673 other ARB users were followed for 54 285 and 260 390 person‐years, respectively, during which 9237 endpoint events occurred. Lower‐dose olmesartan was not associated with increased risk for any endpoint, regardless of duration of use. High‐dose olmesartan for 6 months or longer was associated with increased risk of death in patients with diabetes (HR 2.03, 95%CI 1.09–3.75, p = 0.02) and with reduced risk in nondiabetic patients (HR 0.46, 95%CI 0.24–0.86, p = 0.01). Some, but not all, sensitivity analyses suggested that selective prescribing of olmesartan to healthier patients (channeling bias) may have accounted for the reduced risk in nondiabetic patients.ConclusionsHigh‐dose olmesartan was associated with an increased risk of death in diabetic patients treated for 6 months or longer and with a reduced risk of death in nondiabetic patients, when compared with use of other ARBs. This latter effect was probably because of selective prescribing of olmesartan to healthier patients, although effect modification cannot be excluded. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
Inclusion of the orientational entropic effect and low‐resolution experimental information for protein–protein docking in Critical Assessment of PRedicted Interactions (CAPRI)
Authors: Huang Sheng‐You , Yan Chengfei , Grinter Sam Z. , Chang Shan , Jiang Lin , Zou Xiaoqin 
Published: November 2013

ABSTRACTInclusion of entropy is important and challenging for protein–protein binding prediction. Here, we present a statistical mechanics‐based approach to empirically consider the effect of orientational entropy. Specifically, we globally sample the possible binding orientations based on a simple shape‐complementarity scoring function using an FFT‐type docking method. Then, for each generated orientation, we calculate the probability through the partition function of the ensemble of accessible states, which are assumed to be represented by the set of nearby binding modes. For each mode, the interaction energy is calculated using our ITScorePP scoring function that was developed in our laboratory based on principles of statistical mechanics. Using the above protocol, we present the results of our participation in Rounds 22‐27 of the Critical Assessment of PRedicted Interactions (CAPRI) experiment for 10 targets (T46–T58). Additional experimental information, such as low‐resolution small‐angle X‐ray scattering data, was used when available. In the prediction (or docking) experiments of the 10 target complexes, we achieved correct binding modes for six targets: one with high accuracy (T47), two with medium accuracy (T48 and T57), and three with acceptable accuracy (T49, T50, and T58). In the scoring experiments of seven target complexes, we obtained correct binding modes for six targets: one with high accuracy (T47), two with medium accuracy (T49 and T50), and three with acceptable accuracy (T46, T51, and T53). Proteins 2013; 81:2183–2191. © 2013 Wiley Periodicals, Inc.
The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins
Authors: Lohman Jeremy R. , Ma Ming , Cuff Marianne E. , Bigelow Lance , Bearden Jessica , Babnigg Gyorgy , Joachimiak Andrzej , Phillips George N. , Shen Ben 
Published: November 2013

ABSTRACTCarrier proteins (CPs) play a critical role in the biosynthesis of various natural products, especially in nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymology, where the CPs are referred to as peptidyl‐carrier proteins (PCPs) or acyl‐carrier proteins (ACPs), respectively. CPs can either be a domain in large multifunctional polypeptides or standalone proteins, termed Type I and Type II, respectively. There have been many biochemical studies of the Type I PKS and NRPS CPs, and of Type II ACPs. However, recently a number of Type II PCPs have been found and biochemically characterized. In order to understand the possible interaction surfaces for combinatorial biosynthetic efforts we crystallized the first characterized and representative Type II PCP member, BlmI, from the bleomycin biosynthetic pathway from Streptomyces verticillus ATCC 15003. The structure is similar to CPs in general but most closely resembles PCPs. Comparisons with previously determined PCP structures in complex with catalytic domains reveals a common interaction surface. This surface is highly variable in charge and shape, which likely confers specificity for interactions. Previous nuclear magnetic resonance (NMR) analysis of a prototypical Type I PCP excised from the multimodular context revealed three conformational states. Comparison of the states with the structure of BlmI and other PCPs reveals that only one of the NMR states is found in other studies, suggesting the other two states may not be relevant. The state represented by the BlmI crystal structure can therefore serve as a model for both Type I and Type II PCPs. Proteins 2014; 82:1210–1218. © 2013 Wiley Periodicals, Inc.