bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemical Study of Chondrolipoma: Possible Importance of Transforming Growth Factor (TGF) ‐βs, Latent TGF‐ β Binding Protein‐1 (LTBP‐1), and Bone Morphogenetic Protein (BMP) for Chondrogenesis in Lipoma
Authors: Nakano Mineo , Arai Eiichi , Nakajima Yuji , Nakamura Hiroaki , Miyazono Kohei , Hirose Takanori 
Published: July 2014

AbstractTo clarify the pathogenesis of chondrolipoma, we examined the expressions and localizations of TGF‐β1, ‐β2, ‐β3, BMP, and LTBP‐1 in our rare case by immunohistochemical staining, and compared them with the staining patterns seen in normal human tracheal cartilage tissue and osteochondroma (controls). In the present case, there was weak TGF‐β1 expression in both lacuna and spindle cells around the cartilage, intense TGF‐β2 expression in both lacuna and spindle cells, and weak‐to‐moderate TGF‐β3 expression in the spindle cells. In lacuna cells, LTBP‐1 was expressed moderately and BMP intensely. In contrast, the normal cartilage showed weak‐to‐moderate expressions of TGF‐β2, ‐β3, and BMP in the lacuna cells with zero‐to‐weak TGF‐β2 and zero‐to‐moderate TGF‐β3 expressions in the spindle cells, while LTBP‐1 was negative in both lacuna and spindle cells. Osteochondroma cases showed moderate‐to‐intense expressions of TGF‐β2, ‐β3, and BMP in the lacuna cells, while LTBP‐1 was positive in the lacuna cells and negative in the spindle cells. These findings suggest that the pattern of expression of TGF‐βs, LTBP‐1, and BMP may be important in the pathogenesis of chondrolipoma.
Report of a Turkish Child with Sjögren‐Larsson Syndrome Associated with Peripheral Nerve Involvement
Authors: Akdeniz Necmettin , Çalka Ömer , Anlar Ömer , Akbayram Sinan , Çaksen Hüseyin , Metin Ahmet , Çinal Adnan 
Published: July 2014

AbstractSjögren‐Larsson syndrome is a rare hereditary neurocutaneous disorder characterized by ichthyosis, spastic di‐ or tetra‐plegia, and mild to moderate mental retardation. In this article, we present a nine‐year‐old girl with the classical features of the syndrome associated with peripheral nerve involvement because of its rare presentation. To the best of our knowledge, only three cases of Sjögren‐Larsson syndrome with peripheral nerve involvement have been previously reported in the literature. We assume that Sjögren‐Larsson syndrome involves extensive disorders of the ectodermal tissues, including the peripheral nerves as well as the skin and the central nervous system.
Relapsing Ulcerative Papules over Bilateral Hands and Scrotum in an Asian Man: An Atypical Manifestation of Primary Cutaneous CD30‐Positive Lymphoma
Authors: Lan Cheng‐Che E. , Yu Hsin‐Su , Cheng Shih‐Tsung , Chen Gwo‐Shing 
Published: July 2014

AbstractA 33‐year‐old Taiwanese man presented at our clinic with multiple erythematous ulcerated papules over his bilateral hands. CD30‐positive anaplastic large cell lymphoma (CD30+ ALCL) was diagnosed by an incisional biopsy. After a thorough survey for extracutaneous involvement, the diagnosis of primary cutaneous CD30+ ALCL was established. Due to spontaneous regression of some skin lesions, the patient refused therapeutic intervention. Subsequently, an ulcerative nodule arose over the scrotum. It spontaneously regressed 5 weeks later. Although histologically alarming, this particular lymphoma bears favorable prognosis. Thus, recognition of this entity is of great importance, because it may prevent patients from undergoing unnecessary aggressive treatment. To our knowledge, CD30+ ALCL has not been reported to evolve in the pattern similar as observed in our patient. Thus, this Asian man presents a rare presentation of CD30+ ALCL.
Basal Cell Carcinoma on the Right Hallux
Authors: Matsushita Kiyomi , Kawada Akira , Aragane Yoshinori , Tezuka Tadashi 
Published: July 2014

AbstractBasal cell carcinomas (BCCs) usually develop in sun‐exposed areas. The finger, toe, and nail unit are very rare sites of BCC. We describe a patient with BCC on the right hallux. Clinically, it appeared as a brown‐colored small plaque with an irregular border on the nail fold and dorsum of the right hallux. Histopathological findings were consistent with the superficial type of BCC.
Expression of Basic Fibroblast Growth Factor, Vascular Endothelial Growth Factor, and Thrombospondin‐1 Related to Microvessel Density in Nonaggressive and Aggressive Basal Cell Carcinomas
Authors: Oh Chang‐Keun , Kwon Yoo‐Wook , Kim You‐Sun , Jang Ho‐Sun , Kwon Kyung‐Sool 
Published: July 2014

AbstractThe aggressive forms of basal cell carcinoma (BCC) are biologically different in a number of features from their nonaggressive counterparts. The expression of basic Fibroblast Growth Factor (bFGF), Vascular Endothelial Growth Factor (VEGF), and Thrombospondin‐1 (TSP‐1) was examined in primary culture samples of nonaggressive and aggressive BCCs. We studied the relationship between neoangiogenesis by counting microvessels, tumor aggressiveness, and the expression of three different angiogenic factors. bFGF mRNA was detectable in all BCC samples, but there was no significant difference in the levels of expression between the two types. VEGF mRNA was also detectable in all BCC samples. VEGF expression in the aggressive type was approximately 3.5‐fold higher than in the nonaggressive type. TSP‐1 expression was variable and not related to the type of BCC. The mean value of microvessel density (MVD) was significantly higher for the aggressive type than for the nonaggressive type. There was a significant correlation between VEGF levels and MVD. No significant relationships were found between bFGF, TSP‐1 mRNA expression, and MVD. In conclusion, the results of present study suggest that VEGF expression and angiogenesis might play important roles in the progression to aggressive BCC.
A Cardiac Allograft Recipient with Bowen's Disease on a Finger and Concurrent Perianal Bowenoid Papulosis
Authors: Ibe Miha , Kawase Masaaki , Ishiji Takaoki , Kamide Ryoichi , Niimura Michihito 
Published: July 2014

AbstractWe report a patient who developed Bowen's disease of the finger and bowenoid papulosis of the perianal area after cardiac transplantation. Human papillomavirus (HPV) type 16 only, not any skin‐related or epidermodysplasia verruciformis‐related types, was detected in both lesions by in situ hybridization and polymerase chain reaction. The same virus type was identified in both the tumor of the finger and the perianal area, which suggests contact transmission. HPV 16 has often been associated with malignant changes and may be at least one source of the malignancies that are more common in immunosuppressed patients. The presence of a potentially oncogenic type of the HPV in an immunosuppressed patient highlights the importance of regular follow‐up of such patients.
Inguinal Keratotic Basal Cell Carcinoma Mimicking Giant Solitary Trichoepithelioma
Authors: Şahin Mustafa Turhan , Demir Mehmet Akif , Kaya Yavuz , Can Mine , İnanir Işil , Öztürkcan Serap 
Published: July 2014

AbstractKeratotic basal cell carcinoma may not only clinically but also histologically share more or less the same features with giant solitary trichoepithelioma. It can be difficult to distinguish these two entities from each other, even for an experienced dermatopathologist. We present an unusual case of inguinal keratotic basal cell carcinoma mimicking giant solitary trichoepithelioma in a 56‐year‐old woman with a finger‐like tumor of 20 years duration. The patient presented with an asymptomatic, skin colored, firm, nonulcerative, nodular lesion. Scanty mitotic activity and apoptotic cells were the histopathologic findings against basal cell carcinoma, whereas absence of papillary mesenchymal bodies, presence of peritumoral lacunae detected only around the solid areas, and accumulation of amyloid‐like hyalinized material were the findings in favor of basal cell carcinoma. This case illustrates that keratotic basal cell carcinoma must be taken into account in the differential diagnosis of inguinally located solitary, polypoid masses, especially giant solitary trichoepithelioma.
Disseminated Cellulitic Cryptococcosis in the Setting of Prednisone Monotherapy for Pemphigus Vulgaris
Authors: Yoo Simon S. , Tran Mark , Anhalt Grant , Barrett Terry , Vonderheid Eric C. 
Published: July 2014

AbstractCryptococcal infections are seen mainly in immunocompromised hosts. The cutaneous manifestations of infection can include papules, plaques, nodules, vesicles, ulcers, ecchymosis, and, rarely, cellulitis. Cryptococcal meningitis is a life‐threatening complication of this disease. Pemphigus vulgaris is a rare auto‐immune blistering disease that can also be life‐threatening. Treatment of pemphigus commonly entails both corticosteroids and steroid‐sparing agents. We present a case of disseminated cryptococcal infection in a patient with pemphigus vulgaris treated with high dose corticosteroids as monotherapy. This case provides an opportunity to discuss the difficulty of managing two potentially mortal conditions in which the treatment of pemphigus vulgaris may exacerbate the disseminated cryptococcal infection.
Unilesional Mycosis Fungoides Mimicking Bowen's Disease
Authors: Yoo Simon S. , Viglione Michael , Moresi Margaret , Vonderheid Eric 
Published: July 2014

AbstractCutaneous T‐cell lymphoma includes a heterogeneous group of lymphomas that share the unique feature of T lymphocytes which are tropic to the skin. Clinically, the presentation of this disease is protean and can range from a single lesion to generalized erythroderma. Unilesional mycosis fungoides, a rare variant, is presented here. Its morphology mimicked squamous cell carcinoma in situ, and was refractory to conventional therapies. A review of the treatment of this subset is also presented.
Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients
Authors: Kaneko Takahide , Tamai Katsuto , Yamazaki Takehiko , Harada Ken , Nakano Hajime , Hanada Katsumi 
Published: July 2014

AbstractSuperficial granulomatous pyoderma (SGP) is an unusual variant type of pyoderma gangrenosum characterized by a benign course and specific histological features; it is quite a rare cutaneous disorder in Japan. We reported two Japanese cases of SGP and compared the clinical features of 13 Japanese cases with those of 42 foreign cases. Case 1 was a 53‐year‐old female who presented with three indolent and ulcerative plaques with elevated edges on the back and the posterior portion of the left thigh. Case 2 was a 74‐year‐old female who presented with crusted and vegetative erythematous plaques on the left shoulder and left upper arm. Histological examinations revealed a characteristic three‐layer granuloma in each case. Laboratory and physical examinations found no abnormalities. Topical corticosteroid, oral administration of minocycline, and/or additional supplementation with corticosteroid were effective. In comparison with foreign cases, Japanese cases show a possible differentiation in the ratio of sex and distribution of the ulcer. Females have a high incidence and the extremities are frequently involved area in Japanese cases. Up to now, 11 cases of SGP have been reported in Japan. To our best knowledge, our patients are the first Japanese cases described in the English literature.
A Giant Cystic Hygroma on the Leg of a Newborn Infant Complicated by Hyponatremia
Authors: Tastekin Ayhan , Ermis Bahri , Polat Pinar , Yildirim Mustafa , Ors Rahmi 
Published: July 2014

AbstractCystic hygromas are large cystic masses resulting from failure of lymph drainage. The vast majority occur in the neck or axilla. Cases of cystic hygroma of the extremity are extremely rare. We present a newborn infant with a giant cystic hygroma on her left leg, complicated by severe hyponatremia.
Resolution of a Leg Ulcer after Hysterectomy for Huge Uterine Myoma
Authors: Ohtani Tomoyuki , Tanita Muneo , Tagami Hachiro 
Published: July 2014

AbstractVenous ulcers are the most common type of leg ulcers, accounting for 80% to 90% of cases. We report a large, therapy‐resistant ulcer present for three months on the right leg of a 44‐year‐old woman who also had a huge uterine myoma. Without any other treatment, the leg ulcer regressed spontaneously three months after a hysterectomy for the uterine myoma that had been demonstrated in a CT image to be compressing the right common iliac vein in the pelvis. Uterine myoma can become the cause of venous insufficiency of the leg, when it is big enough to disturb the blood circulation in the pelvis in individuals who have incompetent perforating veins.
A Giant Melanocytic Nevus Treated with Combined Use of Normal Mode Ruby Laser and Q‐Switched Alexandrite Laser
Authors: Kono Taro , Ercocen Ali Riza , Kikuchi Yuji , Isago Tsukasa , Honda Takashi , Nozaki Motohiro 
Published: July 2014

AbstractWe report a combination procedure that can improve the effectiveness of laser removal of giant congenital melanocytic nevi (CMN). A 2‐year‐old girl with a giant CMN was seen in our outpatient clinic. Histological findings showed a compound nevus without any evidence of malignancy or dysplastic changes. The patient was treated with the normal mode ruby laser and Q‐switched alexandrite laser. The lesion was significantly improved in color and cosmetic appearance. Partial hypopigmentation and texture changes were observed. Histological findings showed a marked decrease in the number of junctional melanocytes and the nests in the papillary and reticular dermis. The combined laser treatment is an effective method for the treatment of giant CMN, but further study is warranted to follow‐up questions of recurrence and malignant change.
Malignant Melanoma of Soft Parts (Clear Cell Sarcoma): A Case Report
Authors: Seike Takuya , Matsumoto Kazuya , Nakanishi Hideki , Hashimoto Ichiro , Kubo Yoshiaki , Arase Seiji 
Published: July 2014

AbstractA subcutaneous tumor localized on the sole of the foot of a 25‐year‐old Japanese man was diagnosed as a malignant melanoma of the soft parts. We performed a wide local excision, elective lymph node dissection, and chemotherapy. Eight years after treatment, the patient is alive without local recurrence or metastasis.
Dilated Pore: A Case Report and an Immunohistochemical Study of Cytokeratin Expression
Authors: Morikawa Takahito , Takizawa Hajime , Ohnishi Takamitsu , Watanabe Shinichi 
Published: July 2014

AbstractWe report a 71‐year‐old Japanese female with a dilated pore in the form of a nodule above her right eyebrow. Histologic examination revealed a flask‐shaped, keratinous cystic structure that was continuous with the surface epidermis and had numerous elongated rete ridges in the lower portion. An immunohistochemical study using a panel of monoclonal antibodies against cytokeratins (CKs) and involucrin detected CK1 and CK10 in the suprabasal cells of the cystic structure. CK8 and CK19 expression was observed in the outermost layer of some elongated rete ridges; it was composed of pallisading columnar cells. Most parts of the outermost layer of the cystic structure stained positively with AE1 antibody. From these immunohistochemical findings, we speculated that the dilated pore in our case was an isolated clinical entity is a follicular tumor differentiating mainly toward the infundibulum and partly toward the isthmus.
Lipoid Proteinosis in Two Siblings: A Report from India
Authors: Sethuraman Gomathy , Tejasvi Trilokraj , Khaitan Binod K. , Handa Kumud K. , Rao Satish , Singh Manoj K. , Sirka Chandrasekhar , Sharma Vinod K. 
Published: July 2014

AbstractLipoid proteinosis is an autosomally recessive genodermatosis characterized by widespread deposition of eosinophilic hyaline‐like material in the skin, mucous membranes, and other internal organs. Occurrence of lipoid proteinosis in siblings is very rare. We report two siblings from the Indian subcontinent with the classical features of lipoid proteinosis. Both the siblings had had hoarseness of voice and spontaneous vesicular eruptions healing with atrophic scars since their early childhood. They had diffuse waxy thickening of the skin along with beaded papules along the eyelid margin. The tongue was also infiltrated. Skin biopsy demonstrated periodic acid Schiff (PAS) positive eosinophilic material around the blood vessels and appendages.
A Case of Lupus Vulgaris with Unusual Location
Authors: Senol Mustafa , Ozcan Atilla , Mizrak Bulent , Turgut A. Ciler , Karaca Semsettin , Kocer Hulya 
Published: July 2014

AbstractTuberculosis (TB) is one of the oldest diseases of our planet; today, it still is a serious medicosocial problem in both developing and developed countries. Cutaneous tuberculosis is part of the small percentage of extrapulmonary forms of the disease and has considerable morphological variability. It is often confused with various cutaneous disorders and some other granulomatous processes of the skin. Here, we present a case of long‐standing and atypically‐located lupus vulgaris in an old man. The patient was successfully treated with triple antituberculous therapy.
Effects of Different Negative Pressures on Reduction of Wounds in Negative Pressure Dressings
Authors: Isago Tsukasa , Nozaki Motohiro , Kikuchi Yuji , Honda Takashi , Nakazawa Hiroaki 
Published: July 2014

AbstractNegative pressure dressings stimulate the healing of tissue‐deficient wounds by applying continuous or intermittent negative pressure. This study was designed to determine the most effective negative pressure level for the reduction of the wound by using negative pressure dressings in animal studies. Fifty male Wister rats weighting 200–250 grams were used throughout the study. The animals were divided into five groups of ten animals each as follows: group 1: No negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. Group 2–5: 25, 50, 75 and 125 mmHg negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. The wounds were measured along the vertical and horizontal lengths of the body axis and the wound area was calculated. The reduction of the wound area was weaker in the group with a negative pressure of 25 mmHg, and similarly higher among the groups with negative pressures of 50, 75, or 125 mmHg. There were no significant differences in the reduction of the wound area among the latter three groups.
Painful Indurated Erythema Suggestive of Kikuchi‐Fujimoto Disease in a Patient with Primary Sjögren's Syndrome
Authors: Miyashita Yuko , Yamaguchi Masahide , Fujimoto Wataru 
Published: July 2014

AbstractWe report a patient with primary Sjögren's syndrome who developed pyrexia, cervical lymphadenopathy, and painful indurated erythema on the forehead, back, chest, abdomen, and limbs. Laboratory data showed an elevated erythrocyte sedimentation rate, C‐reactive protein and CH50 in addition to existing autoantibodies including anti‐nuclear antibody, anti SS‐A antibody, and anti SS‐B antibody. A skin biopsy specimen showed focal infiltration of histiocytes with non‐neutrophilic karyorrhetic debris in the dermis and subcutaneous fat tissue. Immunohistochemically the infiltrated cells were stained for CD68, suggesting cutaneous involvement of Kikuchi‐Fujimoto disease. All symptoms and laboratory data improved within three weeks after treatment with 20 mg/day of prednisolone. The present case suggests that a pathophysiological condition similar to Kikuchi‐Fujimoto disease can develop during the long‐term course of Sjögren's syndrome.
Melkersson‐Rosenthal Syndrome Caused by Saprodontia: A Case Report
Authors: Tadokoro Taketsugu , Ozawa Kentaro , Muso Yumi , Ito Haruyasu , Itami Satoshi , Yoshikawa Kunihiko 
Published: July 2014

AbstractA 24‐year‐old female patient with Melkersson‐Rosenthal syndrome (MRS) in association with saprodontia is reported. She presented with lower labial swelling and left facial edema. Histological examination of the involved oral mucosa showed a noncaseating epithelioid granuloma. Results from the laboratory and imaging examinations were normal or negative. Her orofacial swelling disappeared after treatment of the saprodontia of the left first molar.
Primary Cutaneous Follicle Center Cell Lymphoma of the Scalp Successfully Treated with Anti CD20 Monoclonal Antibody and CHOP Combination Therapy with No Subsequent Permanent Loss of Hair
Authors: Imai Yasutomo , Isoda Ken‐ichi , Ito Emiko , Hakamada Arata , Yamanishi Kiyofumi , Mizutani Hitoshi 
Published: July 2014

AbstractWe present a primary cutaneous follicle center cell lymphoma (PCFCCL) patient who was successfully treated with Rituximab, a new anti‐CD20 monoclonal antibody. A thirty‐two‐year‐old male developed two asymptomatic tumors on the scalp. Histopathologically, the tumors were composed of diffuse and nodular infiltration of centrocytes and centroblasts. Immunohistopathologically, the tumor cells stained positively with anti‐CD20 antibody and anti‐kappa antibody, but not with anti‐CD5, anti‐CD10, or anti‐Bcl‐2 antibody. Radiation therapy is effective in treating PCFCCL; however, it usually results in the permanent loss of hair. This patient was treated with Rituximab and CHOP, and achieved a complete remission. He has had no recurrence in more than 12 months and no permanent loss of hair on the scalp.
Dermatological Side Effects of Brimonidine: A Report of Three Cases
Authors: Sodhi Punita Kumari , Verma Lalit , Ratan John 
Published: July 2014

AbstractBrimonidine is a potential first line therapy for primary open angle glaucoma (OAG) and ocular hypertension (OHT). It is known to cause various ocular and systemic side effects. Being a newer drug, the whole spectrum of its adverse effects is not known. The dermatological side effects caused by brimonidine have rarely been reported before. We present three OAG patients who presented to us with contact dermatitis of periorbital skin and lichen planus of nail following the use of topical brimonidine (0.2% twice a day) for more than six months. These side effects slowly disappeared on discontinuing the drug but reappeared on reintroducing topical formulation. Such side effects from the use of brimonidine have not been reported before.
Estrogen Dermatitis That Appeared Twice in Each Menstrual Period
Authors: Murano Keimei , Koyano Taeko 
Published: July 2014

AbstractA 23‐year‐old woman presented with millet‐sized red papules that were scattered over her chest and abdomen. She stated that since the age of 20, she had recurrently suffered from pruritic eruptions that coincided with ovulation and the time prior to menstruation, and that they persisted for a few days before vanishing spontaneously leaving some pigmentation. A skin biopsy specimen revealed spongiotic bullae in the epidermis and marked infiltration of lymphocytes accompanied by some histiocytes and eosinophils in the upper dermis. An intradermal test for conjugated estrogen showed an urticarial reaction that faded in about four hours. Although the test did not strictly meet the criterion (erythema to remain for more than 24 hours for papulovesicular eruptions), it was concluded that the timing of the episodes along with the result of the test suggested that a diagnosis of estrogen dermatitis was highly probable. There have been several reports of this condition since it was first reported as a distinct entity in 1995; but whatever the reasons, the flares were observed only before menstruation in these cases, despite the fact that the serum estrogen levels showed a double‐peaked pattern during each menstrual period. This is considered to be a rare case of estrogen dermatitis that flared twice in each menstrual period. Limited improvement was noted in the symptoms even without treatment.