bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault Prediction and Maintenance of Non‐Periodic Incipient Fault for Hydraulic Tube Tester
Authors: Zhao Zhen , Zhang Jun , Wang Shu , Chang Yuqing , Jia Mingxing 
Published: February 2014

AbstractThis paper is concerned with fault prediction and maintenance for the hydraulic tube tester according to the process variables. For the two types of incipient faults of this machine, it is more difficult to predict the non‐periodic incipient fault and make a predictive maintenance decision in comparison with the periodic incipient fault. For the non‐periodic incipient fault, a new probabilistic fault prediction method is proposed using a multivariate principle component analysis and Bayesian auto‐regression model. Then, a new predictive maintenance policy is developed, based on the results of the probabilistic fault prediction approach, which implies the evolvement of system deterioration caused by the non‐periodic incipient fault. Simulation results demonstrate the effectiveness of the method proposed in this paper.
Zonal rate model for axial and radial flow membrane chromatography, part II: Model‐based scale‐up
Authors: Ghosh Pranay , Lin Min , Vogel Jens H. , Choy Derek , Haynes Charles , von Lieres Eric 
Published: February 2014

ABSTRACTMembrane chromatography (MC) systems are finding increasing use in downstream processing trains for therapeutic proteins due to the unique mass‐transfer characteristics they provide. As a result, there is increased need for model‐based methods to scale‐up MC units using data collected on a scaled‐down unit. Here, a strategy is presented for MC unit scale‐up using the zonal rate model (ZRM). The ZRM partitions an MC unit into virtual flow zones to account for deviations from ideal plug‐flow behavior. To permit scale‐up, it is first configured for the specific device geometry and flow profiles within the scaled‐down unit so as to achieve decoupling of flow and binding related non‐idealities. The ZRM is then configured for the preparative‐scale unit, which typically utilizes markedly different flow manifolds and membrane architecture. Breakthrough is first analyzed in both units under non‐binding conditions using an inexpensive tracer to independently determine unit geometry related parameters of the ZRM. Binding related parameters are then determined from breakthrough data on the scaled‐down MC capsule to minimize sample requirements. Model‐based scale‐up may then be performed to predict band broadening and breakthrough curves on the preparative‐scale unit. Here, the approach is shown to be valid when the Pall XT140 and XT5 capsules serve as the preparative and scaled‐down units, respectively. In this case, scale‐up is facilitated by our finding that the distribution of linear velocities through the membrane in the XT140 capsule is independent of the feed flow rate and the type of protein transmitted. Introduction of this finding into the ZRM permits quantitative predictions of breakthrough over a range of industrially relevant operating conditions. Biotechnol. Bioeng. 2014;111: 1587–1594. © 2014 Wiley Periodicals, Inc.
Myoblast alignment on 2D wavy patterns: Dependence on feature characteristics and cell‐cell interaction
Authors: Grigola Michael S. , Dyck Casey L. , Babacan Derin S. , Joaquin Danielle N. , Hsia K. Jimmy 
Published: February 2014

ABSTRACTIn this study, we investigate the effects of micron‐scale surface patterns on the alignment of individual cells and groups of cells. Using a simple replication molding process we produce a number of micron‐scale periodic wavy patterns with different pitch and depth. We observe C2C12 cells as they grow to confluence on these patterns and find that, for some geometries, cell‐cell interaction leads to global alignment in a confluent culture when individual cells would not align on the same pattern. Three types of alignment behavior are thus defined: no alignment, immediate alignment, and alignment upon confluence. To further characterize this response, we introduce a non‐dimensional parameter that describes the aligning power of a periodic pattern based on its geometry. The three types of alignment behavior can be distinguished by the value of the alignment parameter, and we identify values at which the transitions in alignment behavior occur. Applying this parameter to data from the current and several earlier studies reveals that the parameter successfully describes substrate aligning power over a wide range of length scales for both wavy and grooved features. Biotechnol. Bioeng. 2014;111: 1617–1626. © 2014 Wiley Periodicals, Inc.
Spatiotemporal distribution of SUMOylation components during mouse brain development
Authors: Hasegawa Yuta , Yoshida Daisuke , Nakamura Yuki , Sakakibara Shin‐ichi 
Published: February 2014

ABSTRACTPosttranslational modification of proteins might play an important role in brain cellular dynamics via the rapid turnover or functional change of critical proteins controlling neuronal differentiation or synaptic transmission. Small ubiquitin‐like modifier protein (SUMO) is a family of ubiquitin‐like small proteins that are covalently attached to target proteins to modify their function posttranslationally. Many cellular processes, such as transcription and protein trafficking, are regulated by SUMOylation, but its functional significance in the brain remains unclear. Although developmental regulation of SUMOylation levels in rat brain was recently demonstrated, no comparative immunohistochemical analysis of the cellular distribution profiles of SUMOylation components, including SUMO1, SUMO2/3, and Ubc9, has been undertaken so far. The present study used immunohistochemical and immunoblot analysis with the different developmental stages of mice and demonstrated the developmentally regulated distribution of SUMO1, SUMO2/3, and Ubc9 in the brain. During embryonic development, SUMOylation by SUMO1 and SUMO2/3 occurred in the nucleoplasm of nestin‐positive neural stem cells. Although the total amount of SUMO‐modified proteins decreased during postnatal brain development, intense and persistent accumulation of SUMO2/3 was detected throughout life in neural progenitor populations in neurogenic regions, including the subventricular zone and the hippocampal subgranular zone. In contrast, many neurons in the adult brain accumulated SUMO1 rather than SUMO2/3. Heavy immunoreactivity of SUMO1 was found in large projection neurons in the brainstem, whereas SUMO2/3 was almost absent from these areas. This heterogeneous distribution implies that both proteins play a specific and unique role in the brain. J. Comp. Neurol. 522:3020–3036, 2014. © 2014 Wiley Periodicals, Inc.
trans‐Hexahydrobenzoxazolidinones in the Enantioselective Synthesis of β2‐Amino Acids Containing Proteinogenic Side Chains
Authors: Bandala Yamir , Reyes‐Rangel Gloria , Obregón‐Zúñiga Arturo , Cruz‐Hernández Carlos , Corzo Gerardo , Juaristi Eusebio 
Published: February 2014

AbstractThe use of enantiopure trans‐hexahydrobenzoxazolidinones as chiral auxiliaries in the enantioselective synthesis of two β2‐amino acids containing proteinogenic side chains (β2‐hPhenylalanine and β2‐hLysine), in both enantiomeric forms, is described. Absolute configurations were assigned on the basis of X‐ray diffraction analysis and chemical correlation methods.
Design, Synthesis, and X‐ray Structural Analyses of Diamantane Diammonium Salts: Guests for Cucurbit[n]uril (CB[n]) Hosts
Authors: Šekutor Marina , Molčanov Krešimir , Cao Liping , Isaacs Lyle , Glaser Robert , Mlinarić‐Majerski Kata 
Published: February 2014

AbstractNew bisprimary and bisquaternary diamantane‐1,6‐ and ‐4,9‐diammonium/diaminium salts were synthesized, and characterized by NMR spectroscopy and X‐ray crystallography. The impetus for these syntheses were previously reported X‐ray crystallographic investigations of adamantane mono‐ and bisquaternary ammonium ions [3,5‐diMeAda‐1‐NH3 or Ada‐1,3‐di(NMe3)] complexed with cucurbit[n]uril (n = 7, 8). The crystal structures were analyzed to ascertain possible structural hypotheses for high binding affinity guests bound within various diameter pumpkin‐shaped hosts. Although Diam‐4,9‐di(NMe3I) 5 could be readily prepared from the bisprimary precursor, corresponding Diam‐1,6‐di(NMe3I) 14 could not be obtained even under strong reaction conditions. Stereochemical analysis of this situation suggests very severe steric non‐bonding cis‐1,3‐diaxial type H···H interactions between the “axial”‐type NMe3 group and neighboring “axial” proton neighbors. These same interactions are found in Ada‐2,6‐di(NMe3I) analogues, but they are alleviated in this smaller polycyclic skeleton through tilting the axial C(methylene)–NMe3 bond away from its axial neighbors. However, similar structural relief for Diam‐1,6‐di(NMe3I) is not possible, because the C(methine)–NMe3 bond therein is ligated to the diamondoid's rigid skeleton.
Function‐Oriented Synthesis of Liponucleoside Antibiotics
Authors: Tanino Tetsuya , Yamaguchi Mayumi , Matsuda Akira , Ichikawa Satoshi 
Published: February 2014

AbstractFunction‐oriented synthesis of a class of liponucleoside antibiotics was investigated through rational simplification guided by previous structure–activity relationship studies of caprazamycins and muraymycins to address the issue associated with their molecular complexity. A lactam‐fused isoxazolidine scaffold was designed, and a diverse set of lactam‐fused isoxazolidines derivatives were constructed by intramolecular 1,3‐dipolar cycloaddition of alkenyl nitrones. Several analogues exhibited moderate activity against a range of Gram‐positive drug‐resistant bacterial pathogens.
Evaluation of the anti‐inflammatory and antinociceptive effects of myrtenol, a plant‐derived monoterpene alcohol, in mice
Authors: Silva Renan O. , Salvadori Mirian S. , Sousa Francisca Beatriz M. , Santos Maisa S. , Carvalho Nathalia S. , Sousa Damião P. , Gomes Bruno S. , Oliveira Francisco A. , Barbosa André Luiz R. , Freitas Rivelilson M. , de Almeida Reinaldo Nóbrega , Medeiros Jand‐Venes R. 
Published: February 2014

ABSTRACTInflammation is characterized by vasodilatation, increase of blood flow and vascular permeability, migration of leucocytes to the inflammatory site, and production of cytokines. The aim of this study was evaluate the anti‐inflammatory and antinociceptive effects of (−)‐myrtenol, a plant‐derived monoterpene alcohol, in mice and its possible mechanisms. Myrtenol was used in classical models of inflammation (paw oedema induced by different agents, carrageenan‐induced peritonitis, myeloperoxidase levels and cytokine measurement) and nociception (acetic acid‐induced writhing, hot‐plate test, and paw licking induced by formalin, glutamate, and capsaicin). Pretreatment with myrtenol effectively inhibited paw oedema induced by carrageenan, compound 48/80, histamine, serotonin and prostaglandin E2. Myrtenol also reduced the cell counts, myeloperoxidase activity and cytokine levels (interleukin 1β, but not tumour necrosis factor‐α) of the peritoneal cavity induced by carrageenan. In addition, myrtenol inhibited acetic acid‐induced writhing, did not significantly prolong the latency time in the hot‐plate test, decreased licking time caused by an intraplantar injection of formalin (only in the second phase), glutamate and capsaicin. Myrtenol reduces the inflammatory response and nociception in mice due to the inhibition of the release of inflammatory mediators, cell migration and also to the signalling pathway of receptors involved in the transmission of pain. Copyright © 2014 John Wiley & Sons, Ltd.
Investigation of morphometric variability of subthalamic nucleus, red nucleus, and substantia nigra in advanced Parkinson's disease patients using automatic segmentation and PCA‐based analysis
Authors: Xiao Yiming , Jannin Pierre , D'Albis Tiziano , Guizard Nicolas , Haegelen Claire , Lalys Florent , Vérin Marc , Collins D. Louis 
Published: February 2014

AbstractSubthalamic nucleus (STN) deep brain stimulation (DBS) is an effective surgical therapy to treat Parkinson's disease (PD). Conventional methods employ standard atlas coordinates to target the STN, which, along with the adjacent red nucleus (RN) and substantia nigra (SN), are not well visualized on conventional T1w MRIs. However, the positions and sizes of the nuclei may be more variable than the standard atlas, thus making the pre‐surgical plans inaccurate. We investigated the morphometric variability of the STN, RN and SN by using label‐fusion segmentation results from 3T high resolution T2w MRIs of 33 advanced PD patients. In addition to comparing the size and position measurements of the cohort to the Talairach atlas, principal component analysis (PCA) was performed to acquire more intuitive and detailed perspectives of the measured variability. Lastly, the potential correlation between the variability shown by PCA results and the clinical scores was explored. Hum Brain Mapp 35:4330–4344, 2014. © 2014 Wiley Periodicals, Inc.
Summary of proceedings of the second World Congress on Thyroid Cancer
Authors: Czerwonka Lukasz , Freeman Jeremy , McIver Bryan , Randolph Gregory W. , Shah Jatin P. , Shaha Ashok R. , Sherman Steven I. , Tuttle R. Michael , Witterick Ian J. 
Published: February 2014

ABSTRACTThe second World Congress on Thyroid Cancer was held from July 10 to July 14, 2013, in Toronto, Canada. Its purpose was to provide a platform for the multidisciplinary discussion on research, education, and patient management of thyroid malignancy. Herein, we summarize the latest major trends and controversies within the field of thyroid oncology as discussed in the Congress including the use of ultrasound, standardization of cytology, role of molecular testing, treatment options for small recurrence including ablation and observation, management of recurrent laryngeal nerve injury, importance of identification of the external branch of the superior laryngeal nerve, role of minimally invasive thyroid surgery, trends in radioactive iodine treatment, advancements in targeted agents, and the importance of personalizing treatment to individual patients. © 2014 Wiley Periodicals, Inc. Head Neck 36: 917–920, 2014
Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL‐6 and IL‐8
Authors: Shiheido Hirokazu , Kitagori Koji , Sasaki Chiyomi , Kobayashi Shio , Aoyama Takane , Urata Kozue , Oku Takuma , Hirayama Yoshitaka , Yoshitomi Hiroyuki , Hikida Masaki , Yoshifuji Hajime , Mimori Tsuneyo , Watanabe Takeshi , Shimizu Jun 
Published: February 2014

AbstractBEN domain‐containing protein 3 (BEND3) has no transmembrane region, is localized in the cytoplasm, and is involved in chromatin function and transcription. We here identified a novel subpopulation of human T cells that expressed BEND3 on their cell surface (BEND3+ T cells). BEND3+ T cells consisted of approximately 3% of T cells in the peripheral blood, were present in both CD4+ and CD8+ T cells, and were also observed in cord blood. The stimulation of BEND3+ T cells through the TCR/CD3 complex led to the production of various kinds of cytokines; however, the levels of IL‐6 and IL‐8 produced by BEND3+ T cells were higher than those by BEND3− T cells. The proportion of BEND3+ T cells was also increased in some patients with inflammatory diseases. Taken together, these results indicate that BEND3+ T cells are a new subpopulation of T cells in terms of their cytokine profile. Further analyses on BEND3+ T cells may be of importance and useful in understanding human T cell immunology.
Adsorption of Glycosaminoglycans to the Cell Surface Is Responsible for Cellular Donnan Effects
Authors: Hagenfeld Daniel , Kathagen Nadine , Prehm Peter 
Published: February 2014

ABSTRACTIn previous publications, we showed that extracellular glycosaminoglycans reduced the membrane potential, caused cell blebbing and swelling and decreased the intracellular pH independently of cell surface receptors. These phenomena were explained by Donnan effects. The effects were so large that they could not be attributed to glycosaminoglycans in solution. Therefore, we tested the hypothesis that glycosaminoglycans were concentrated on the cell membrane and analysed the mechanism of adsorption by fluorescent hyaluronan, chondroitin sulphate and heparin. The influence of the CD44 receptor was evaluated by comparing CD44 expressing human fibroblasts with CD44 deficient HEK cells. Higher amounts of glycosaminoglycans adsorbed to fibroblasts than to HEK cells. When the membrane potential was annihilated by substituting NaCl by KCl in the medium, adsorption was reduced and intracellular pH decrease was abolished. To eliminate other cellular interfering factors, potential‐dependent adsorption was demonstrated for hyaluronan which adsorbed to inert gold foils in physiological salt concentrations at pH 7.2 and surface potentials up to 120 mV. From these results, we conclude that large cellular Donnan effects of glycosaminoglycans results from receptor mediated, hydrophobic and ionic adsorption to cell surfaces. J. Cell. Biochem. 115: 1334–1341, 2014. © 2014 Wiley Periodicals, Inc.
Instantaneous signal loss simulation (InSiL): An improved algorithm for myocardial T1 mapping using the MOLLI sequence
Authors: Shao Jiaxin , Nguyen Kim‐Lien , Natsuaki Yutaka , Spottiswoode Bruce , Hu Peng 
Published: February 2014

PurposeTo propose a T1 mapping algorithm for the modified Look‐Locker inversion‐recovery (MOLLI) sequence that can improve T1 estimation accuracy.Materials and MethodsThe modified T1 mapping algorithm (InSiL) is based on the simulation of MOLLI signal evolution and simulates the longitudinal magnetization signal perturbation by each single‐shot image acquisition in MOLLI as an instantaneous signal loss. InSiL was evaluated against original MOLLI using Bloch simulations, phantom studies, and in 15 healthy volunteers at 1.5T.ResultsIn phantom studies, the maximum absolute error by InSiL is less than 2%, while that by MOLLI is more than 20% for T1 values from 221 msec to 1539 msec. The benefit of InSiL is greatest at heart rate (HR) >80 bpm and T1 >1000 msec, and InSiL reduced MOLLI T1 error from 14.9 ± 4.5% to 0.4 ± 0.3%. Average InSiL‐derived native myocardial T1 values at 1.5T in healthy volunteers were significantly higher than MOLLI‐derived values by 236.9 ± 11.7 msec (1160.3 ± 25.1 msec vs. 923.4 ± 22.3 msec, P < 0.001) at an average HR of 65.1 ± 14.7 bpm.ConclusionThe proposed InSiL approach yields better T1 mapping accuracy than MOLLI, and is less sensitive to HR variation in tissues with longer T1 values. J. Magn. Reson. Imaging 2015;41:721–729. © 2014 Wiley Periodicals, Inc.
β‐NaYF4:Yb3+, Er3+ upconversion microcrystals with both high emission intensity and controlled morphology
Authors: Suli Wu , Ye Liu , Jie Chang , Yanhui Ning , Shufen Zhang 
Published: February 2014

AbstractUpconversion emission intensity and morphology are both important features of NaYF4:Yb3+, Er3+ microcrystals. In this paper, myristic acid (MA) is selected as a novel stabilizing ligand to synthesize NaYF4:Yb3+, Er3+ through a facile hydrothermal method. Upconversion fluorescence spectra indicate that the emission intensity of product prepared with MA as ligand has increased dramatically compared with the sample prepared using commonly used oleic acid (OA) as ligand. Field emission scanning electron microscopy (FE‐SEM) results display that the morphology of NaYF4:Yb3+, Er3+ obtained using MA as ligand can be tuned from nanodisk, nanorod to nanotube. Especially, nanotube with clear caves can be prepared directly with proper concentration of base (NaOH). And powder X‐ray diffraction (XRD) analysis reveals a relationship between the phase transformation process and the amount of NaOH. With increasing the amount of NaOH, the transition process of cubic phase to hexagonal phase is accelerated. The effect of F− and OH− on the fluorescence properties of NaYF4:Yb3+, Er3+ are studied systematically. A gradual increase of the amount of NaF results in a regular increase of the emission intensity. On the contrary, the emission intensity decreases with increasing the amount of NaOH. In addition, reasonable explanations of the influence of F− and OH− on emission intensity are given as well.
Nucleophilic Substitution of Tetrachloroperylene Diimide in Fluorescent Polyvinylpyrrolidone Film
Authors: Sun Mengmeng , He Yong , Ye Yong , Yang Wantai , Yin Meizhen 
Published: February 2014

A stable fluorescent polyvinylpyrrolidone (PVP) film is successfully prepared in one pot by using N,N′‐bis‐(2,6‐diisopropylphenyl)‐1,6,7,12‐tetrachloroperylene‐3,4,9,10‐tetracarboxyldi­imide (4Cl‐PDI) as the fluorophore. Aromatic nucleophilic substitution between the chlorine atom in 4Cl‐PDI and the secondary amine in ring‐opened PVP is proposed and demonstrated by a small‐molecule model reaction. In contrast, N,N′‐bis(2,6‐diisopropylphenyl)‐perylene‐3,4,9,10‐tetracarboxyl diimide (PDI), which does not possess any chlorine atoms, has no such functions and can be easily disassociated from the produced PVP film. The chlorine atom is essential for the covalent bonding of the 4Cl‐PDI molecules in the fluorescent PVP film, thus leading to stable optical properties. The facile synthesis approach is especially suitable for the preparation of fluorescent PVP film, by using perylene species as the fluorophore, which usually contains a halogen element in the bay region.
image
A spectral element method using the modal basis and its application in solving second‐order nonlinear partial differential equations
Authors: Fakhar–Izadi Farhad , Dehghan Mehdi 
Published: February 2014

AbstractWe present a high‐order spectral element method (SEM) using modal (or hierarchical) basis for modeling of some nonlinear second‐order partial differential equations in two‐dimensional spatial space. The discretization is based on the conforming spectral element technique in space and the semi‐implicit or the explicit finite difference formula in time. Unlike the nodal SEM, which is based on the Lagrange polynomials associated with the Gauss–Lobatto–Legendre or Chebyshev quadrature nodes, the Lobatto polynomials are used in this paper as modal basis. Using modal bases due to their orthogonal properties enables us to exactly obtain the elemental matrices provided that the element‐wise mapping has the constant Jacobian. The difficulty of implementation of modal approximations for nonlinear problems is treated in this paper by expanding the nonlinear terms in the weak form of differential equations in terms of the Lobatto polynomials on each element using the fast Fourier transform (FFT). Utilization of the Fourier interpolation on equidistant points in the FFT algorithm and the enough polynomial order of approximation of the nonlinear terms can lead to minimize the aliasing error. Also, this approach leads to finding numerical solution of a nonlinear differential equation through solving a system of linear algebraic equations. Numerical results for some famous nonlinear equations illustrate efficiency, stability and convergence properties of the approximation scheme, which is exponential in space and up to third‐order in time. Copyright © 2014 John Wiley & Sons, Ltd.