bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protective effect of taurine against liver disorder induced by gentamicin in male rats
Authors: Saad Kahyoon Orass , H. Flayyih Salam , G, Al-Fartosi Khalid 
Published: July 2024

The present study was carried out to investigate the effects of an amino acid taurine on gentamicin-induced liver disorder in male rats. Twenty four male rats were used in this study, the animals divided into four groups, each group contained six rats including: G1 normal group, G2 injection IP with 100mg/kg of gentamicin only for 10 days, G3 injection IP with 100mg/kg of taurine only for 10 days, G4 injection IP with 100mg/kg of gentamicin and injection IP with 100mg/kg of taurine for 10 days, The result shows significant increase (p<0.05) in liver enzymes ALT, AST, ALP and significant increase in TC, TG, LDL with marked decrease in HDL levels in gentamicin group compared with normal group. This animal study suggests that the treatment with gentamicin plus taurine protects against gentamicin-induced acute liver injury by a significant (p<0.05) and improvement in the biochemical markers of liver and normalized lipid profiles.
The Study of Histopathological Changes in Some of Intermediate Hosts Infected With Cystic Echinococcosis
Authors: Jasim Hansh Wesam 
Published: July 2024

The present study aimed to investigate the histopathological changes in liver and lung of sheep, cattle and buffaloes, spleen of cattle and lung of human infected with cystic echinococcosis (Hydatidosis). The infected organs with hydatid cysts were collected from abattoir of Nassiriyah municipality in Thi-Qar province, southern of Iraq and preserved immediately in 10% formalin solution. The gross examination noticed that liver and lung more affected organs with infection of cystic echinococcosis, also harden area was observed around the hydatid cyst and all these cysts were unilocular. The present study showed that the defensive response of hosts represented by formation of massive fibrous layer which surrounded the hydatid cysts in liver, lung and spleen of sheep, cattle and buffaloes. The fibrosis surrounded the hydatid cyst in lung of human was noticed in this study, also the blood vessels in lung were affected by complications of hydatid cyst. The infiltration of inflammatory cells against expanding cysts was observed in liver of sheep and cattle infected with hydatid cysts. The calcification associated with fibrosis in liver of cattle and buffaloes infected with hydatid cysts was noticed while did not demonstrate in liver of sheep. The degeneration of hepatocytes and enlargement of bile duct was recorded in infected cattle.
The histopathological changes in lungs of infected hosts represented by the dilatation of pulmonary alveoli in lung of sheep and cattle, also the cystic echinococcosis is affected on the bronchiole by proliferation of bronchial epithelium in cattle.
Screening and sensitivity of non-lactose fermenting bacteria to antibiotics by Vitek-2 compact system
Authors: Khaleel Ibrahim Hanaa 
Published: July 2024

We are collected 150 clinical sample from different private veterinary clinics in Basrah province . Included 25 isolates from nasal discharge, 45 from feces , 35 from pus/wound infections, 20 from blood and 25 from ear swab .All isolates were subjected to microscopic examination and diagnosed 4 species of Non- Fermenting Gram Negative Bacilli (NFGNB) bacteria based on 47 biochemical tests by Vitek 2 a compact system where the species were 48 strain (32%) of Pseudomonas aeruginosa , 32 strain (21.33%) of Burkholderia cepacia, 31strain (20.66%) of Sphingomonas paucimobilis, 20 strain (13.33%) of Proteus mirabilis and 19 strain (12.66%) of Acinetobacter calcoaceticus . NFGNB results showed antibiotic susceptibility to different antibiotic resistance and susceptibility, where isolates showed Pseudomonas aeruginosa, Burkholderia cepacia and Proteus mirabilis were susceptibility to antibiotic Meropenem (80% -98%), while Acinetobacter spp, Pseudomonas aeruginosa least susceptible to Cefuroxime and Trimethoprim/Sulfamethoxazole (20% – 30%). The bacteria showed Sphingomonas paucimobilis showed resistance to all the antibiotics tested. The current study was carried out with the aim of diagnosing and identifying NFGNB isolated from clinical samples and evaluating their clinical importance and study of antibiotic resistance.
Gemini Surfactant Performance Evaluation as Inhibitive action of PAPM for Treatment of AISI steel Corrosion and Studying Temperatures Influence in Acidic Medium
Authors: Jerri  Meften Mushtaq 
Published: July 2024

To inhibit corrosion of the AISI 4130 steel in 1M H2SO4 solution at different temperatures, the gemini surfactant was used, namely N,N'-((1,4-phenylenebis(azanediyl)) bis (2-hydroxy propane-3,1-diyl)) bis (N,N-dimethyldecan-1-aminium) (PAPM). The gemini surfactant by electrochemical impedance spectroscopy technique and weight loss method has been evaluated at different temperatures 30, 40 and 50°C. The gemini surfactant showed a very good performance as a corrosion inhibitor in acidic solution, and inhibition efficiency increases with increase inhibitor concentration but decreased with increasing temperatures. Impedance technique results shown, that studied molecule act as mixed-type inhibitor toward AISI steel, also values of standard free energy of adsorption suggest the physisorption and chemisorption were occurred for inhibitor molecules on AISI surface. In addition, the inhibitor adsorption behavior on the AISI surface was investigated at specified temperatures and it coincide with Langmuir’s adsorption isotherm. Furthermore, time effect on corrosion inhibition efficiency was studied where results shown that influence was slight. From quantum calculations, the inhibitor act as soft molecule were noted, also it was shown that the inhibitor more responding for reacting with the AISI surface and prefer the electrophilic attack because it contains on a nucleophilic centers. Experimental inhibition efficiency obtained from both two methods are on a good agreement to each other where optimum efficiency reached 90.32% for weight loss method and 87.17% for EIS technique. On other hand, theoretical inhibition efficiency and experimental inhibition efficiency were in a good agreement to each other, where as theoretical efficiency reached 92.35%.
Interdiffusion of Zinc-Stannate Buffer Layer and Cadmium Sulfide Heterojunction and Its Correlation with CdCl2 Treatment
Authors: Ayad Khedhair Al-mebir Alaa 
Published: July 2024

In this paper, a highly transparent and conductive Zinc Stannate (Zn2SnO4) buffer layer is integrated between the transparent conductive oxide (TCO) layer and the Cadmium Sulfide (CdS) window layer to improve the optical properties of (TCO\Zn2SnO4\CdS\CdTe) heterojunctions in CdTe\CdS solar cells. This buffer layer is used to reduce the excess interdiffusion between the window and absorber layers when Ultra-thin CdS window layer, d < 100 nm, is employed, and post CdCl2 treatment is applied at high temperature after deposition of CdTe layer. The fabricated Zinc Stannate (Zn2SnO4) buffer layer was found to have ideal transmission, reflectance and absorption properties which helped in introducing good optical properties in the short wavelengths. It has been found that using the Zn2SnO4 buffer layer enhanced the short circuit current Jsc and the open circuit voltage Voc of the solar cells that used Ultra-thin CdS thickness (80nm) by preventing TCO\CdTe direct contact, and led to improved solar cells’ performance and reproducibility.
Identification of Novel Variants of Three Zephyranthes Species Through Multilocation Assessment
Authors: Lal M , Baruah J , Darnei Rl , Begum T 
Published: July 2024

Zephyranthes spp. (Rain lily) are priced ornamentals known for their brightly coloured flowers that gently naturalize the surroundings. They contain rich sources of alkaloids that are well known for their pharmacological activities. Breeding work in rain lily is extensively difficult; it is performed to add value as ornamentals. The present study was undertaken to identify and develop three novel variants of Zephyranthes- Z. rosea, Z. citrina, Z. candida through multilocation assessment. Initial field trial was conducted with fifteen germplasm for each species during spring 2018, 2019 and identified one lines for each species- RRL-PRL-05 (Z. rosea), RRL-YRL-02 (Z. candida) and RRL-WRL-27 (Z. citrina). RRL-PRL-05 with bright pink flowers and flat, broad leaves; RRL-YRL-02 showed bright yellow flowers with flat narrow leaves while RRL-WRL-27 showed white flowers with fine hairlike leaves. Multilocation study conducted for two consecutive years showed the identified lines to be stable for quantitative characters and colour combinations.
Bangladesh J. Bot. 53(2): 265-271, 2024 (June)
Biomarker-guided detection of acute kidney injury in abdominal aortic surgery: the new and the old
Authors: Nusshag Christian , Theobald Vivienne , Wortmann Markus , Kaimann Philipp , Dietrich Maximilian , Gruneberg Daniel , Tourelle Kevin , von der Forst Maik , Weigand Markus A. , Bischoff Moritz S. , Böckler Dittmar , Schmitt Felix C. F. 
Published: July 2024

IntroductionAcute kidney injury (AKI) is a common complication in patients undergoing major vascular surgery. Despite significant research efforts in this area, the incidence of AKI remains high, posing a significant challenge to healthcare systems, especially in situations where resources are limited. Early prediction of AKI severity and individualized postoperative care is therefore essential.MethodsThe primary objective of this exploratory study was to assess the diagnostic value of urine cell-cycle arrest biomarkers [(TIMP-2) × (IGFBP7)] and soluble urokinase plasminogen activator receptor (suPAR) for predicting moderate or severe AKI within 24 h after open aortic surgery, and compared to routine kidney biomarkers. Seventy-five patients undergoing elective aortic surgery were included. Clinical parameters, urine and blood samples were collected preoperatively, immediately postoperatively, and 24 h later. AKI was defined using KDIGO criteria. Individual and combined diagnostic performance of biomarkers were evaluated.ResultsOf the 75 patients, 61% developed AKI, of which 28% developed moderate or severe AKI within 24 h of surgery. Baseline demographics, comorbidities and kidney parameters did not differ between patients with moderate or severe AKI (AKI II/III) and none or mild AKI (AKI 0/I), except for higher preoperative suPAR levels in later AKI II/III patients. Urine osmolality, Cystatin C and serum creatinine had the highest predictive power for AKI II/III with AUCs of 0.75–0.72. (TIMP-2) × (IGFBP7), and neither (TIMP-2) × (IGFBP7) nor suPAR individually showed superior diagnostic value. Combining CysC or SCr with urine osmolality and 6 h urine output gave the best performance with AUCs of 0.86 (95% CI, 0.74–0.96) and 0.85 (95% CI, 0.75–0.95) respectively.ConclusionOur study suggests that routine parameters like urine osmolality, CysC, SCr and 6 h urine output perform best in predicting postoperative AKI after aortic surgery compared to the new biomarkers (TIMP-2) × (IGFBP7) and suPAR. Combining biomarkers, particularly CysC or SCr with urine output, urine osmolality, may enhance diagnostic accuracy. Further validation in larger cohorts and clinical settings is warranted to establish their clinical utility.
AC-ASPECTS, ACh-ASPECTS, and H-ASPECTS: new imaging scales to assess territorial and total cerebral hemispheric ischemic injury
Authors: Rodriguez Maria Paz , Taleb Shayandokht , Lee Jenny Ji-hyun , Liebeskind David S. , Saver Jeffrey L. 
Published: July 2024

BackgroundThe extent of ischemic injury in acute stroke is assessed in clinical practice using the Acute Stroke Prognosis Early CT Score (ASPECTS) rating system. However, current ASPECTS semi-quantitative topographic scales assess only the middle cerebral artery (MCA) (original ASPECTS) and posterior cerebral (PC-ASPECTS) territories. For treatment decision-making in patients with anterior cerebral artery (ACA) occlusions and internal carotid artery (ICA) occlusions with large ischemic cores, measures of all hemispheric regions are desirable.MethodsIn this cohort study, anatomic rating systems were developed for the anterior cerebral (AC-ASPECTS, 3 points) and anterior choroidal artery (ACh-ASPECTS, 1 point) territories. In addition, a total supratentorial hemisphere (H-ASPECTS, 16 points) score was calculated as the sum of the MCA ASPECTS (10 regions), supratentorial PC-ASPECTS (2 regions), AC-ASPECTS (3 regions), and ACh-ASPECTS (1 region). Three raters applied these scales to initial and 24 h CT and MR images in consecutive patients with ischemic stroke (IS) due to ICA, M1-MCA, and ACA occlusions.ResultsImaging ratings were obtained for 96 scans in 50 consecutive patients with age 74.8 (±14.0), 60% female, NIHSS 15.5 (9.25–20), and occlusion locations ICA 34%; M1-MCA 58%; and ACA 8%. Treatments included endovascular thrombectomy +/− thrombolysis in 72%, thrombolysis alone in 8%, and hemicraniectomy in 4%. Among experienced clinicians, inter-rater reliability for AC-, ACh-, and H-ASPECTS scores was substantial (kappa values 0.61–0.80). AC-ASPECTS abnormality was present in 14% of patients, and ACh-ASPECTS abnormality in 2%. Among patients with ACA and ICA occlusions, H-ASPECTS scores compared with original ASPECTS scores were more strongly associated with disability level at discharge, ambulatory status at discharge, discharge destination, and combined inpatient mortality and hospice discharge.ConclusionAC-ASPECTS, ACh-ASPECTS, and H-ASPECTS expand the scope of acute IS imaging scores and increase correlation with functional outcomes. This additional information may enhance prognostication and decision-making, including endovascular thrombectomy and hemicraniectomy.
Efficacy of personalized rTMS to enhance upper limb function in subacute stroke patients: a protocol for a multi-center, randomized controlled study
Authors: Lee Ho Seok , Kim Dae Hyun , Seo Han Gil , Im Sun , Yoo Yeun Jie , Kim Na Young , Lee Jungsoo , Kim Donghyeon , Park Hae-Yeon , Yoon Mi-Jeong , Kim Young Seok , Kim Hyunjin , Chang Won Hyuk 
Published: July 2024

BackgroundRepetitive transcranial magnetic stimulation (rTMS) is widely used therapy to enhance motor deficit in stroke patients. To date, rTMS protocols used in stroke patients are relatively unified. However, as the pathophysiology of stroke is diverse and individual functional deficits are distinctive, more precise application of rTMS is warranted. Therefore, the objective of this study was to determine the effects of personalized protocols of rTMS therapy based on the functional reserve of each stroke patient in subacute phase.MethodsThis study will recruit 120 patients with stroke in subacute phase suffering from the upper extremity motor impairment, from five different hospitals in Korea. The participants will be allocated into three different study conditions based on the functional reserve of each participant, measured by the results of TMS-induced motor evoked potentials (MEPs), and brain MRI with diffusion tensor imaging (DTI) evaluations. The participants of the intervention-group in the three study conditions will receive different protocols of rTMS intervention, a total of 10 sessions for 2 weeks: high-frequency rTMS on ipsilesional primary motor cortex (M1), high-frequency rTMS on ipsilesional ventral premotor cortex, and high-frequency rTMS on contralesional M1. The participants of the control-group in all three study conditions will receive the same rTMS protocol: low-frequency rTMS on contralesional M1. For outcome measures, the following assessments will be performed at baseline (T0), during-intervention (T1), post-intervention (T2), and follow-up (T3) periods: Fugl-Meyer Assessment (FMA), Box-and-block test, Action Research Arm Test, Jebsen-Taylor hand function test, hand grip strength, Functional Ambulatory Category, fractional anisotropy measured by the DTI, and brain network connectivity obtained from MRI. The primary outcome will be the difference of upper limb function, as measured by FMA from T0 to T2. The secondary outcomes will be the differences of other assessments.DiscussionThis study will determine the effects of applying different protocols of rTMS therapy based on the functional reserve of each patient. In addition, this methodology may prove to be more efficient than conventional rTMS protocols. Therefore, effective personalized application of rTMS to stroke patients can be achieved based on their severity, predicted mechanism of motor recovery, or functional reserves.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT06270238.
Does chronic kidney disease affect the short-term outcomes and prognosis of colorectal cancer surgery? A propensity score matching analysis
Authors: Qu Shu-Pei , Rao Si-Qi , Hai Zhan-Xiang , Wang Chun-Yi 
Published: July 2024

PurposeThe aim of this study was to analyze the effect of chronic kidney disease (CKD) on the short-term outcomes and prognosis of colorectal cancer (CRC) patients who underwent primary surgery.MethodsCRC patients who underwent radical surgery were included from Jan 2011 to Jan 2020 in a single hospital. The short-term outcomes and prognosis were compared between the CKD group and the Non-CKD group using propensity score matching (PSM) analysis.ResultsA total of 4056 patients undergoing CRC surgery were included, including 723 patients in the CKD group and 3333 patients in the Non-CKD group. After 1:1 PSM, there were 666 patients in each group, respectively. No significant difference was found in baseline characteristics between the two groups. (p&gt;0.05). After PSM, the CKD group had a longer postoperative hospital stay (P=0.009) and a higher incidence of overall complications (p=0.050). Cox analysis was performed on matched patients to find predictors of overall survival (OS) and disease-free survival (DFS). We found that age (p&lt;0.01, HR=1.045, 95% CI=1.028–1.062), tumor stage (p&lt;0.01, HR=1.931, 95% CI=1.564–2.385) and overall complications (p&lt;0.01, HR=1.858, 95% CI=1.423–2.425) were independent predictors of OS. Age (p&lt;0.01, HR=1.034, 95% CI=1.020–1.049), tumor stage (p&lt;0.01, HR=1.852, 95% CI=1.537–2.231), and overall complications (p&lt;0.01, HR=1.651, 95% CI=1.295–2.10) were independent predictors of DFS. However, CKD was not an independent predictor of OS or DFS (OS: p=0.619, HR=1.070, 95% CI=0.820–1.396; DFS: p=0.472, HR=1.092, 95% CI=0.859–1.389).ConclusionCKD prolonged postoperative hospital stay; however, CKD might not affect major postoperative complications, OS or DFS of CRC.
Synovial fibroblasts from children with oligoarticular juvenile idiopathic arthritis induce migration and prolong viability of neutrophils
Authors: Schmidt Tobias , Mossberg Anki , Berthold Elisabet , Król Petra , Linge Petrus , Bengtsson Anders A. , Kahn Fredrik , Månsson Bengt , Kahn Robin 
Published: July 2024

IntroductionLittle is known of the processes that trigger neutrophil activation in the joint of patients with oligoarticular juvenile idiopathic arthritis (oJIA), and if synovial fibroblasts (S-Fib) play an important role in the activation. Therefore, we aimed to investigate whether S-Fib derived from oJIA patients drive neutrophil activation.MethodsSynovial fluid (SF) was collected from patients with oJIA. S-Fib were isolated from the SF of n = 7 patients through passaging. Subsequently, the S-Fib were primed or not with 20% of pooled SF. Supernatants were used to study migration of neutrophils in a transwell system. Additionally, the influence of S-Fib on neutrophils were studied in co-cultures. Phenotype and viability were assessed by flow cytometry. Neutrophil function was tested through the production of reactive oxygen species (ROS), and supernatants were tested for myeloperoxidase (MPO) release and elastase activity.ResultsSupernatants of S-Fib induced neutrophil migration (n = 5, p = 0.0491), which was further pronounced using supernatants from SF-primed S-Fib (p = 0.0063). Additionally, co-culture between SF-primed S-Fib and neutrophils resulted in prolonged viability (n = 5, p = 0.0094), with little effect on activation markers, e.g., CD11b. Conversely, co-culture did not induce functional alterations (n = 4), such as production of ROS (p &gt; 0.1570), release of MPO (p &gt; 0.4934) or elastase activity (p &gt; 0.0904). Finally, supernatant stimulation did not replicate the results of prolonged viability (p = 0.9102), suggesting a role of cell-contact.ConclusionS-Fib from patients with oJIA induce migration of neutrophils via soluble mediators and, in addition, S-Fib prolong neutrophil viability in a cell-contact dependent manner. These mechanisms could be important for accumulation of neutrophils during arthritis.
Cascaded multiplier-free implementation of adaptive anti-jamming filter based on GNSS receiver
Authors: Song Jie , Chen Lei , Lu Zukun , Li Baiyu , Liu Zhe , Xue Zhihao , Sun Guangfu , Liu Wenhong 
Published: July 2024

Evaluating the computational complexity is critical for assessing the time-domain anti-jamming performance of GNSS receivers. The multiplier is the core component that contributes to the computational complexity in time-domain anti-jamming. However, current algorithms aimed at reducing the complexity of time-domain anti-jamming typically concentrate on shortening the filter length, which fails to address the high computational complexity introduced by the use of multipliers. This paper introduces a cascaded multiplier-free approach for implementing time-domain anti-jamming in navigation receivers. We propose a numerical power decomposition technique based on optimal Canonical Signed Digit coding and coefficient decomposition. By substituting the multiplier with minimal adder and shift operations, the computational complexity of the anti-jamming filter with a high quantization bit-width can be considerably decreased. An optimization strategy is presented, and the low-complexity multiplier-free technique is applied to the time-domain anti-jamming filter. Compared to the traditional Canonical Signed Digit multiplier-free technique, our method can reduce the components required for a 12-bit quantization anti-interference filter by one adder, 20 shift operations, and five coded word lengths, while maintaining a pseudo-range measurement deviation below 0.27 ns.
Ventricular unloading causes prolongation of the QT interval and induces ventricular arrhythmias in rat hearts
Authors: Schwoerer Alexander Peter , Biermann Daniel , Ehmke Heimo 
Published: July 2024

IntroductionVentricular unloading during prolonged bed rest, mechanical circulatory support or microgravity has repeatedly been linked to potentially life-threatening arrhythmias. It is unresolved, whether this arrhythmic phenotype is caused by the reduction in cardiac workload or rather by underlying diseases or external stimuli. We hypothesized that the reduction in cardiac workload alone is sufficient to impair ventricular repolarization and to induce arrhythmias in hearts.MethodsRat hearts were unloaded using the heterotopic heart transplantation. The ECG of unloaded and of control hearts were telemetrically recorded over 56 days resulting in &gt;5 × 106 cardiac cycles in each heart. Long-term electrical remodeling was analyzed using a novel semi-automatic arrhythmia detection algorithm.Results56 days of unloading reduced left ventricular weight by approximately 50%. While unloading did not affect average HRs, it markedly prolonged the QT interval by approximately 66% and induced a median tenfold increase in the incidence of ventricular arrhythmias in comparison to control hearts.ConclusionThe current study provides direct evidence that the previously reported hypertrophic phenotype of repolarization during cardiac unloading translates into an impaired ventricular repolarization and ventricular arrhythmias in vivo. This supports the concept that the reduction in cardiac workload is a causal driver of the development of arrhythmias during ventricular unloading.