bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Enantioselective Synthesis of Boron‐Substituted Quaternary Carbon Stereogenic Centers Through NHC‐Catalyzed Conjugate Additions of (Pinacolato)boron Units to Enones.
Authors: Radomkit Suttipol , Hoveyda Amir H. 
Published: August 2014

AbstractThe enantioselective boryl conjugate addition of bis(pinacolato)diboron to cyclic and linear α,β‐unsaturated ketones leads to corresponding boron‐substituted chiral ketones (III) and (V).
ChemInform Abstract: Ring‐Opening of cis‐3‐Substituted‐2‐vinylaziridines with Heteroatom Nucleophiles.
Authors: Lee Ga‐Eun , Shin Mi‐Ri , Kang Han‐Young 
Published: August 2014

AbstractRing opening reactions of N‐protected 2‐vinylaziridines (I) and (VIII) with alcohols, amines and thiophenol proceed with excellent regio‐ and stereoselectivity.
ChemInform Abstract: Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol.
Authors: Iwasaki Kotaro , Wan Kanny K. , Oppedisano Alberto , Crossley Steven W. M. , Shenvi Ryan A. 
Published: August 2014

AbstractThe presented hydrogenation reaction can be performed at room temperature and is applicable to a broad variety of simple and complex alkenes bearing different functional groups.
ChemInform Abstract: A Concerted Transfer Hydrogenolysis: 1,3,2‐Diazaphospholene‐Catalyzed Hydrogenation of N=N Bond with Ammonia—Borane.
Authors: Chong Che Chang , Hirao Hajime , Kinjo Rei 
Published: August 2014

AbstractThe reduction of azoarenes (I) with ammonia—borane leads to hydrazines (II), whilst the reaction of substrates (III) affords anilines (IV).
ChemInform Abstract: Synthesis of β‐Haloketones by β‐Addition Reactions of α,β‐Unsaturated Ketones with BX3 (X : Br, Cl) as Halide Source.
Authors: Lee Adam Shih‐Yuan , Wang Shu‐Huei , Chang Yu‐Ting 
Published: August 2014

AbstractReaction of α,β‐unsaturated ketones with a slight excess of an equimolar mixture of BBr3 or BCl3 and ethylene glycol offers a straightforward synthesis of β‐haloketones.
ChemInform Abstract: Bis(amidate)bis(amido) Titanium Complex: A Regioselective Intermolecular Alkyne Hydroamination Catalyst.
Authors: Yim Jacky C.‐H. , Bexrud Jason A. , Ayinla Rashidat O. , Leitch David C. , Schafer Laurel L. 
Published: August 2014

AbstractAn efficient, selective, easy to use, and overall general complex for the catalysis of anti‐Markovnikov hydroamination of alkynes is reported.
ChemInform Abstract: Electrophilic Alkynylation of Ketones Using Hypervalent Iodine.
Authors: Utaka Aline , Cavalcanti Livia N. , Silva Luiz F. Jr. 
Published: August 2014

AbstractA new method for the electrophilic α‐alkynylation of ketones is developed using a hypervalent iodine reagent (II).
ChemInform Abstract: Cleavage of the C=N Bond in Carbodiimides via Release of High Ring Strain: A New Strategy for the Selective Synthesis of 2‐Aminoaryl Alkynyl Imines.
Authors: Zhou Yi , Chi Yue , Zhao Fei , Zhang Wen‐Xiong , Xi Zhenfeng 
Published: August 2014

AbstractA novel multicomponent reaction of terminal alkynes or haloalkynes, carbodiimides, and benzynes is achieved via cleavage and reorganization of C=N bond to efficiently obtain the title compounds.
ChemInform Abstract: Copper‐Catalyzed Site‐Selective Intramolecular Amidation of Unactivated C(sp3)—H Bonds.
Authors: Wu Xuesong , Zhao Yan , Zhang Guangwu , Ge Haibo 
Published: August 2014

AbstractThe reaction requires a tertiary α‐carbon atom since N‐quinoline‐protected propane and 2‐methylpropanamide as well as cyclohexane and cyclopentanecarboxamide do not give the desired products.
ChemInform Abstract: One‐Pot Synthesis of Spirooxazino Derivatives via Enzyme‐Initiated Multicomponent Reactions.
Authors: Wang Jun‐Liang , Chen Xiao‐Yang , Wu Qi , Lin Xian‐Fu 
Published: August 2014

AbstractNovozym‐435‐initiated reaction of cyclohexanones, nitrostyrenes, 4‐nitrobenzaldehyde, and acetamide results in the formation of spirooxazines in a single step.
ChemInform Abstract: Synthesis of Oxazolidin‐2‐ones and Imidazolidin‐2‐ones Directly from 1,3‐Diols or 3‐Amino Alcohols Using Iodobenzene Dichloride and Sodium Azide.
Authors: He Tian , Gao Wen‐Chao , Wang Wei‐Kun , Zhang Chi 
Published: August 2014

AbstractIn addition to tosyl‐protected amino alcohols, 4‐nitrobenzenesulfonyl‐ or methanesulfonyl‐protected amines can be used giving similar to lower yields of the corresponding imidazolidin‐2‐ones.
ChemInform Abstract: Three‐Component Coupling Approach for the Synthesis of Diverse Heterocycles Utilizing Reactive Nitrilium Trapping.
Authors: Varadi Andras , Palmer Travis C. , Notis Paula R. , Redel‐Traub Gabriel N. , Afonin Daniel , Subrath Joan J. , Pasternak Gavril W. , Hu Chunhua , Sharma Indrajeet , Majumdar Susruta 
Published: August 2014

AbstractNearly any aryl or alkyl isocyanide is also effective in transforming (I) to (IV) in low to very good yields.
ChemInform Abstract: A Facile and Efficient Synthesis of 2‐(5‐(4‐Substitutedphenyl)‐4,5‐dihydro‐3‐phenylpyrazol‐1‐yl) ‐6‐substitutedbenzothiazoles and Their Biological Studies.
Authors: Munirajasekhar D. , Himaja M. , Mali Sunil V. 
Published: August 2014

Abstract16 Title compounds of type (III) are prepared under microwave irradiation and screened for their antibacterial and anthelmintic activities.
ChemInform Abstract: Synthesis of Dihydrochromeno[4,3‐b]pyrazolo[4,3‐e]pyridin‐6(7H)‐ones Involving One‐Pot Three‐Component Tandem Knoevenagel—Michael Reaction Catalyzed by n‐Tetrabutylammonium Tribromide (TBATB).
Authors: Ghosh Arindam , Khan Abu T. 
Published: August 2014

AbstractA simple protocol for the three‐component reaction of 4‐hydroxycoumarin, pyrazole (II) and aldehydes to give the title compounds via a tandem Knoevenagel‐Michael reaction followed by cyclization.
ChemInform Abstract: Synthesis of Pyrazolo[1,2‐a]cinnolines via a Rhodium‐Catalyzed Oxidative Coupling Approach.
Authors: Xing Li , Fan Zhoulong , Hou Chengyu , Yong Guoping , Zhang Ao 
Published: August 2014

AbstractThe oxidative coupling of N‐arylpyrazolones with terminal alkynes tolerates various substituents in both partners and provides a broad range of pyrazolocinnoline derivatives.
ChemInform Abstract: One‐Step Method for Synthesis of 2,4‐Disubstituted Quinazoline 3‐Oxides by Reaction of a 2‐Aminoaryl Ketone with a Hydroxamic Acid Using Zn(OTf)2 as the Catalyst.
Authors: Madabhushi Sridhar , Mallu Kishore Kumar Reddy , Jillella Raveendra , Kurva Srinivas , Singh Rajpal 
Published: August 2014

AbstractThe title reaction allows the synthesis of quinazoline 3‐oxides in good to excellent yields and tolerates various substituents.
ChemInform Abstract: Heteroannulation of 6‐Polyfluoroalkyl‐2‐thiouracils.
Authors: Khudina O. G. , Ivanova A. E. , Burgart Ya. V. , Slepukhin P. A. , Saloutin V. I. , Chupakhin O. N. , Kravchenko M. A. 
Published: August 2014

AbstractMulti‐component double Mannich cyclocondensation of 6‐polyfluoroalkylthiouracils (III) with formalin and heterocyclic amines provides regiospecifically 3‐hetaryl‐8‐polyfluoroalkylpyrimidothiadiazines (VI) (7 examples).
ChemInform Abstract: NHC—Cu‐Catalyzed Addition of Propargylboron Reagents to Phosphinoylimines. Enantioselective Synthesis of Trimethylsilyl‐Substituted Homoallenylamides and Application to the Synthesis of S‐(‐)‐Cyclooroidin.
Authors: Mszar Nicholas W. , Haeffner Fredrik , Hoveyda Amir H. 
Published: August 2014

AbstractThe title reaction proceeds in very short reaction times with high chemoselectivity to give the allene in mostly 98% vs.
Recent Advances in The Discovery of N‐Myristoyltransferase Inhibitors
Authors: Zhao Can , Ma Shutao 
Published: August 2014

AbstractN‐Myristoyltransferase (NMT) is a cytosolic monomeric enzyme present in eukaryotes such as fungi and protozoa, but is not found in prokaryotes. The attachment of a 14‐carbon saturated fatty acid, myristate, from myristoyl‐CoA (14:0 CoA) to the N‐terminal glycine residue in a specific set of cellular proteins is commonly called protein N‐myristoylation. The myristoylation reaction catalyzed by the enzyme myristoyl CoA:NMT is both necessary for the growth of various organisms and conclusive for cellular proliferation. Therefore, NMT has been identified as a novel and promising target for antifungal, antiparasitic, and anticancer agents, and a large number of potent NMT inhibitors with antifungal, antiparasitic, and anticancer activities have been reported. Herein we describe recent advances in the discovery of NMT inhibitors. We introduce not only the functions of NMT, but also some representative natural and synthetic inhibitors, with a focus on their biological activity, selectivity, and structure–activity relationship (SAR) information. In particular, inspiration from NMT inhibitor structures and the future direction of these compounds are highlighted.
An effective single‐hop distributed hash table with high lookup performance and low traffic overhead
Authors: Monnerat Luiz , Amorim Claudio L. 
Published: August 2014

SUMMARYDistributed hash tables (DHTs) have been used in several applications, but most DHTs have opted to solve lookups with multiple hops, to minimize bandwidth costs while sacrificing lookup latency. This paper presents D1HT, an original DHT that has a peer‐to‐peer and self‐organizing architecture and maximizes lookup performance with reasonable maintenance traffic, and a Quarantine mechanism to reduce overheads caused by volatile peers. We implemented both D1HT and a prominent single‐hop DHT, and we performed an extensive and highly representative DHT experimental comparison, followed by complementary analytical studies. In comparison with current single‐hop DHTs, our results showed that D1HT consistently had the lowest bandwidth requirements, with typical reductions of up to one order of magnitude, and that D1HT could be used even in popular Internet applications with millions of users. In addition, we ran the first latency experiments comparing DHTs to directory servers, which revealed that D1HT can achieve latencies equivalent to or better than a directory server, and confirmed its greater scalability properties. Overall, our extensive set of results allowed us to conclude that D1HT can provide a very effective solution for a broad range of environments, from large‐scale corporate data centers to widely deployed Internet applications. Copyright © 2014 John Wiley & Sons, Ltd.
Polysaccharide‐Based Oleogels Prepared with an Emulsion‐Templated Approach
Authors: Patel Ashok R. , Cludts Nick , Bin Sintang Mohd Dona , Lewille Benny , Lesaffer Ans , Dewettinck Koen 
Published: August 2014

AbstractThe preparation and characterization of oleogels structured by using a combination of a surface‐active and a non‐surface‐active polysaccharide through an emulsion‐templated approach is reported. Specifically, the oleogels were prepared by first formulating a concentrated oil‐in‐water emulsion, stabilized with a combination of cellulose derivatives and xanthan gum, followed by the selective evaporation of the continuous water phase to drive the network formation, resulting in an oleogel with a unique microstructure and interesting rheological properties, including a high gel strength, G′>4000 Pa, shear sensitivity, good thixotropic recovery, and good thermostability.
Ultra‐low‐noise large‐bandwidth transimpedance amplifier
Authors: Giusi Gino , Cannatà Gianluca , Scandurra Graziella , Ciofi Carmine 
Published: August 2014

SummaryEquivalent input current noise and bandwidth are the most relevant parameters qualifying a low‐noise transimpedance amplifier. In the conventional topology consisting of an operational amplifier in a shunt‐shunt configuration, the equivalent input noise decreases as the feedback resistor (RF), which also sets the gain, increases. Unfortunately, as RF increases above a few MΩ, as it is required for obtaining high sensitivity, the bandwidth of the system is set by the parasitic capacitance of RF and reduces as RF increases. In this paper, we propose a new topology that allows overcoming this limitation by employing a large‐bandwidth voltage amplifier together with a proper modified feedback network for compensating the effect of the parasitic capacitance of the feedback resistance. We experimentally demonstrate, on a prototype circuit, that the proposed approach allows to obtain a bandwidth in excess of 100 kHz and an equivalent input noise of about 4 fA/
, corresponding to the current noise of the 1 GΩ resistor that is part of the feedback network. The new approach allows obtaining larger bandwidth with respect to those obtained in previously proposed configurations with comparable background noise. Copyright © 2014 John Wiley & Sons, Ltd.
Synthesis and Two‐Photon Absorption Properties of Ladder‐Type Chromophores with Functionalized Pyrazine Units Fused as the End‐Groups
Authors: Lin Tzu‐Chau , Tsai Bo‐Kai , Liu Yi‐You , Tsai Ming‐Yu 
Published: August 2014

AbstractThree new multipolar chromophores based on ladder‐type units (fluorene, indenofluorene, and bisindenofluorene) as the central π‐bridges and with functionalized pyrazine moieties fused at the molecular terminal positions have been designed and synthesized in order to serve as a set of model compounds for the study of possible effects on the molecular two‐photon absorption (2PA) properties that might be introducible by the structural arrangement. Preliminary experimental results showed that these model dye molecules display broad and intense 2PA in the near‐IR region. Tentative analysis of the relationship between structure and 2PA revealed that the π‐conjugation length of the central oligo‐p‐phenylene component is closely related to the magnitude of overall molecular 2PA and that such a structural motif provides access to highly efficient nonlinear absorbers.
Sensory characterization of Hunter Valley Semillon aged in bottle
Authors: Blackman John W. , Hopfer Helene , Saliba Anthony J. , Schmidtke Leigh M. , Barril Celia , Scollary Geoffrey R. 
Published: August 2014

ABSTRACTThe evolution of sensory characters of white wine cellared under ideal conditions has not previously been studied extensively. The effect of 3 years of bottle ageing of 16 commercial Hunter Valley Semillon (HVS) has been investigated by sensory descriptive analysis. Overall, although primary fruit characters (lemon/lime, grassy, floral, grapefruit and pineapple) generally decreased, some attributes, particularly lemon/lime, remained important features of the wine after the ageing period. Although the grapefruit aroma decreased in all but one wine, none of the decreases were found to have been significant (p < 0.05). Developed characters such as honey, toast and orange marmalade also became more prominent. This study also provides an illustration of the sensory changes in bottled HVS with regard to previously identified HVS styles, with the most noticeable changes occurring in styles categorized by primary fruit characters. Copyright © 2014 John Wiley & Sons, Ltd.
High‐throughput continuous flow femtosecond laser‐assisted cell optoporation and transfection
Authors: Breunig Hans Georg , Uchugonova Aisada , Batista Ana , König Karsten 
Published: August 2014

ABSTRACTWe present a femtosecond‐laser based nanoprocessing system for transient optical cell membrane poration to allow the introduction of foreign molecules into the interior of a cell with very high throughput. In the setup, cells flow through a micro‐flow tube for spatial confinement and are simultaneously targeted by fs laser radiation. Beam‐shaping generates a focal geometry along a line which is scanned across the micro‐flow cell to increase the number of reachable cells. Successful cell membrane poration was observed indirectly by cell transfection even with cell‐light interaction times in the millisecond range. The system was characterized by experiments with Chinese hamster ovary cells regarding cell viability, the uptake of extrinsic molecules and cell transfection efficiency. The continuous flow of cells enables a tremendous increase of cell throughput compared to previous nonflow approaches by treating millions of cells, although with only limited efficiency. The setup opens the possibility to realize a completely automated high‐throughput laser‐assisted cell‐poration system which could be integrated in lab‐on‐a‐chip devices. Microsc. Res. Tech. 77:974–979, 2014. © 2014 Wiley Periodicals, Inc.
Manifold learning based ECG‐free free‐breathing cardiac CINE MRI
Authors: Usman Muhammad , Atkinson David , Kolbitsch Christoph , Schaeffter Tobias , Prieto Claudia 
Published: August 2014

PurposeTo present and validate a manifold learning (ML)‐based method that can estimate both cardiac and respiratory navigator signals from electrocardiogram (ECG)‐free free‐breathing cardiac magnetic resonance imaging (MRI) data to achieve self‐gated retrospective CINE reconstruction.Materials and MethodsIn this work the use of the ML method is demonstrated for 2D cardiac CINE to achieve both cardiac and respiratory self‐gating without the need of an external navigator or ECG signal. This is achieved by sequentially applying ML to two sets of retrospectively reconstructed real‐time images with differing temporal resolutions. A 1D cardiac signal is estimated by applying ML to high temporal resolution real‐time images reconstructed from the acquired data. Using the estimated cardiac signal, a 1D respiratory signal was obtained by applying the ML method to low temporal resolution images reconstructed from the same acquired data for each cardiac cycle. Data were acquired in five volunteers with a 2D golden angle radial trajectory in a balanced steady‐state free precession (b‐SSFP) acquisition. The accuracy of the estimated cardiac signal was calculated as the standard deviation of the temporal difference between the estimated signal and the recorded ECG. The correlation between the estimated respiratory signal and standard pencil beam navigator signal was evaluated. Gated CINE reconstructions (20 cardiac phases per cycle, temporal resolution ∼30 msec) using the estimated cardiac and respiratory signals were qualitatively compared against conventional ECG‐gated breath‐hold CINE acquisitions.ResultsAccurate cardiac signals were estimated with the proposed method, with an error standard deviation in comparison to ECG lower than 20 msec. Respiratory signals estimated with the proposed method achieved a mean cross‐correlation of 94% with respect to standard pencil beam navigator signals. Good quality visual scores of 2.80 ± 0.45 (scores from 0, bad, to 4, excellent quality) were observed for the proposed approach in comparison with the conventional ECG‐gated breath‐hold images (visual score: 3.00 ± 0.71).ConclusionAccurate respiratory and cardiac navigator signals can be estimated using the proposed framework from the acquired data itself, resulting in retrospective self‐gated CINE reconstruction with high spatial and temporal quality. J. Magn. Reson. Imaging 2015;41:1521–1527. © 2014 Wiley Periodicals, Inc.
Using support vector machines to predict cation exchange capacity of different soil horizons in Qingdao City, China
Authors: Liao Kaihua , Xu Shaohui , Wu Jichun , Zhu Qing , An Lesheng 
Published: August 2014

AbstractAgricultural, environmental and ecological modeling requires soil cation exchange capacity (CEC) that is difficult to measure. Pedotransfer functions (PTFs) are thus routinely applied to predict CEC from easily measured physicochemical properties (e.g., texture, soil organic matter, pH). This study developed the support vector machines (SVM)‐based PTFs to predict soil CEC based on 208 soil samples collected from A and B horizons in Qingdao City, Shandong Province, China. The database was randomly split into calibration and validation datasets in proportions of 3:1 using the bootstrap method. The optimal SVM parameters were searched by applying the genetic algorithm (GA). The performance of SVM models was compared to those of multiple stepwise regression (MSR) and artificial neural network (ANN) models. Results show that the accuracy of CEC predicted by SVM improves considerably over those predicted by MSR and ANN. The performance of SVM for B horizon (R2 = 0.85) is slightly better than that for A horizon (R2 = 0.81). The SVM is a powerful approach in the simulation of nonlinear relationship between CEC and physicochemical properties of widely distributed samples from different soil horizons. Sensitivity analysis was also conducted to explore the influence of each input parameter on the CEC predictions by SVM. The clay content is the most sensitive parameter, followed by soil organic matter and pH, while sand content has the weakest influence. This suggests that clay is the most important predictor for predicting CEC of both soil horizons.
Pediatric tracheostomy revisited: A nine‐year experience using horizontal intercartilaginous incision
Authors: Song Jae‐Jin , Choi Ik J. , Chang Hyun , Kim Dong W. , Chang Hyung W. , Park Gyeong‐Hun , Kim Min‐Su , Sung Myung W. , Hah J. Hun 
Published: August 2014

Objectives/HypothesisTo describe our tracheostomy procedure using a vertical skin incision and a horizontal intercartilaginous incision and to compare our postoperative results with those in the recent literature.Study DesignRetrospective chart review and literature review.MethodsOne hundred eleven children underwent tracheostomy using a vertical skin incision and a horizontal intercartilaginous incision over a 9‐year period. A retrospective chart review was undertaken with respect to the following variables: demographics, weight, primary diagnosis, surgical indication, follow‐up duration, decannulation, interval between tracheostomy and decannulation, and complications experienced. In addition, the outcomes were compared to results from a literature review.ResultsOf the 111 patients, 56 had a history of prolonged intubation, 52 had upper airway obstruction, and three underwent tracheostomy for tracheobronchial toileting. Three (2.7%) patients experienced early major complications without major sequelae, and 14 (12.6%) experienced late major complications. Twenty‐one (18.9%) patients were decannulated during the follow‐up period, whereas 17 (17.8%) died of their primary disease or tracheostomy‐related complications (15 died of their primary disease and two died of tracheostomy‐related complications). The complication rates showed overall no differences, but our patient series showed significantly less stomal granulation tissue formation and non‐significant trend for less suprastomal collapse as compared with previous literature.ConclusionsPediatric tracheostomy using a vertical skin incision and horizontal intercartilaginous incision is comparable with the conventional procedure in terms of complication and mortality rates. Future randomized controlled studies are mandatory to directly compare conventional tracheotomy using a vertical skin incision and a horizontal intercartilaginous incision with our procedure.Level of Evidence4. Laryngoscope, 125:485–492, 2015
Thyroarytenoid cross‐innervation by the external branch of the superior laryngeal nerve in the porcine model
Authors: Paskhover Boris , Wadie Mikhail , Sasaki Clarence T. 
Published: August 2014

Objectives/HypothesisCross‐innervation patterns to the thyroarytenoid (TA) muscle have long been sought after. We have identified in the porcine model, cross‐innervation by way of the external branch of the superior laryngeal nerve (eSLN).Study DesignExperimental study.MethodsTA contraction was electromyographically recorded when electrically stimulating the eSLN in six porcine necks. The recurrent laryngeal nerve (RLN) was subsequently transected. The insertion of the cricothyroid (CT) muscle on the cricoid was then subsequently removed as well.ResultsStimulation of the eSLN rendered a response from the TA muscle in 6/6 subject necks, with a mean latency of 2.76 msec. TA muscle contraction by way of eSLN stimulation persisted after the RLN was transected and after CT insertion release.ConclusionsThe TA muscle is directly cross‐innervated by a branch of the eSLN in the porcine model. This finding may have implications regarding possible future laryngeal pacing strategies and could be a target nerve for rehabilitation.Level of EvidenceNA Laryngoscope, 125:177–179, 2015