bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amyloid Deposition Is Frequently Observed in Skin Lesions of Hypertrophic Lupus Erythematosus
Authors: Khan Mohammed Abul Kasem , Maruno Motoyoshi , Khaskhely Noor Mohammad , Uezato Hiroshi , Nonaka Shigeo 
Published: July 2014

AbstractFour cases of Hypertrophic Lupus Erythematosus (HLE) were reported. The lesions of HLE were observed on the forearms, face and hands in all four cases. Clinically, the lesions were erythematous, hyperkeratotic plaques. The clinical course was marked by chronicity and progression of the lesion. Histologically, marked hyperkeratosis, parakeratosis, acanthosis, degenerative changes of basal cells in H/E stain, and thickened, multilayered basement membrane in PAS stain, were observed. The observations of Dylon stain revealed that localized amyloid deposition was observed in all four cases of HLE lesions, as fluorescent‐orange colored amyloid deposits in the papillary dermis and subepidermal areas at near or just below the dermo‐epidermal junction appeared under fluorescent microscope. On the basis of clinical and histological observations, we suggest that chronic irritation, such as sunlight exposure over a long‐duration, might have caused the characteristic abnormalities at the dermo‐epidermal junction and also initiated the frequency of amyloid deposits locally secondary to the diseases. We compared our HLE cases to other types of lupus erythematosus (LE) skin lesions, as to whether deposition of amyloid materials were frequently observed or not. Amyloid deposition was observed in one case of DLE and none of the SLE cases. Localized amyloid deposition was more frequently observed in skin lesions, secondary to HLE disease, as compared to other types of LE.
TCR Gene‐rearranged, Extranodal NK/T‐Cell Lymphoma, Nasal Type, Presenting as Gyrate Patches
Authors: Hwang Dong‐Kyu , Kwon Hyeok‐Man , Park Jin‐Woo , Yu Hee‐Joon , Park Yong Wook 
Published: July 2014

AbstractIn the CD56+ cutaneous nasal‐type NK/T‐cell lymphoma strongly associated with latent EBV infection, subcutaneous or dermal nodules are the most common skin findings, but great morphologic heterogeneity has been noted including papules, infiltrated plaques, and ulcerated tumors, and TCR genes are mostly germline. We describe a case of nasal and nasal‐type NK/T‐cell lymphoma featuring multiple erythematous polycyclic patches on the trunk, which is similar to patch stage mycosis fungoides or other cutaneous T cell lymphoma. Immunohistochemical study of a skin biopsy specimen revealed CD2+, CD3ε+, CD56+, and CD45RO+ expression in the neoplastic cells. In situ hybridization using an anti‐sense Epstein Barr virus early regions probe showed a positive reaction. However, clonal TCR β gene rearrangement was found.
The Japanese Version of Skindex‐16: A Brief Quality‐of‐Life Measure for Patients with Skin Diseases
Authors: Higaki Yuko , Kawamoto Kyoko , Kamo Toshiko , Horikawa Naoshi , Kawashima Makoto , Chren Mary‐Margaret 
Published: July 2014

AbstractA practical quality‐of‐life measure applicable to patients with skin diseases is necessary. Recently developed dermatological quality‐of‐life measures must be translated and adapted for use in cultures other than the ones in which they were created. In this study, we translated and adapted culturally into Japanese a skin‐disease‐specific, brief quality‐of‐life measure, Skindex‐16, and studied its reliability and validity. Forward‐and back‐translations of Skindex‐16 were carried out. Six doubtful items as well as the term “skin condition” required a second forward‐ and back‐translation to reach satisfactory agreement with the original instrument. Cross‐cultural adaptation and cross‐sectional questionnaire studies were then performed to evaluate the reliability and validity of the instrument. One hundred patients and 30 healthy adults responded to the Japanese version. The internal‐consistency reliability of the final Japanese version of Skindex‐16 was high (range of Cronbach's alpha for each scale, symptoms, emotions, and functioning, was 0.83–0.92). The Japanese version showed construct and content validity. As hypothesized, scores for dermatological patients were higher than those for healthy persons (mean global scores 36 ± 23 vs 1 ± 2, p < 0.001) and scores for patients with inflammatory diseases were higher than those for patients with isolated skin lesions (mean global scores 48 ± 21 vs 22 ± 17, p < 0.001), indicating a poorer quality of life. Most patients' responses to an open‐ended question about their skin disease were similar to those of the American responders and were addressed according to the items. In conclusion, we have developed a semantically equivalent translation of Skindex‐16 into Japanese. It is a reliable and valid measure of the effects of skin disease on the quality of life in Japanese patients.
Rapid Effects of Olopatadine Hydrochloride on the Histamine‐Induced Skin Responses
Authors: Morita Keisuke , Koga Tetsuya , Moroi Yoichi , Urabe Kazunori , Furue Masutaka 
Published: July 2014

AbstractOlopatadine hydrochloride is one of the second‐generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis. We examined the inhibitory effects of this drug on the flare and wheal responses induced by histamine iontophoresis at 30, 60, and 90 min after oral administration in a double‐blind, cross‐over, and placebo‐controlled study. Olopatadine hydrochloride significantly inhibited the histamine‐induced flare and wheal responses as early as 60 min after oral administration when compared with placebo. Significant inihibitory effects of olopatadine hydrochloride on the itch responses were seen at 90 min after administration. Thus, olopatadine hydrochloride exhibited a very rapid and potent antihistamine effect on the histamine‐induced skin responses.
PDGF‐BB Induces MAP Kinase Phosphorylation and VEGF Expression in Neurofibroma‐Derived Cultured Cells from Patients with Neurofibromatosis 1
Authors: Kotsuji‐Maruyama Tomoe , Imakado Sumihisa , Kawachi Yasuhiro , Otsuka Fujio 
Published: July 2014

AbstractNeurofibromas of neurofibromatosis 1 (NF1) are highly vascular. Because the number of PDGF β receptors in neurofibroma‐derived cultured cells (NF‐derived cells) has been reported to be increased, we tested whether platelet‐derived growth factor BB (PDGF‐BB) could induce expression of vascular endothelial growth factor (VEGF) in NF‐derived cells. When analysed by reverse transcription‐polymerase chain reaction, VEGF mRNA expression was found to be stimulated by PDGF‐BB and TGF‐β1. Those growth factors stimulated the secretion of VEGF from NF‐derived cells. PDGF‐BB furthermore induced the mitogen‐activated protein kinase phosphorylation in NF‐derived cells from patients with NF1. In conclusion, PDGF‐BB stimulated VEGF secretion in NF‐derived cells, and this stimulation is probably important in neurofibroma hypervascularization.
Immunohistochemical Analysis of the Infiltrated Cells in Tinea Capitis Patients
Authors: Koçak Mukadder , Deveci M. Salih , Ekşioğlu Meral , Günhan Ömer , Yağli Salime 
Published: July 2014

AbstractTinea capitis is a fungal infection of the skin and the hair with involvement of the hair shaft and the pilosebaceous unit. It may be the most common of all cutaneous mycoses in children. Tinea capitis can be inflammatory or noninflammatory. It is thought that humoral and cell‐mediated immunities play a role in the formation of the clinical types of the disease. We studied twelve patients with acute inflammatory disease, four patients with chronic non‐inflammatory disease, and one patient with a black‐dot variant of tinea capitis. The composition of inflammatory infiltrates present in lesional skin was analyzed by antibodies to T cells (CD3) and B cells (CD20). Anti‐CD3 revealed large numbers of T cells in twelve patients with acute, inflammatory dermatophytosis, whereas anti‐CD20 revealed marked infiltrates of both B and T cells in all patients with chronic, non‐inflammatory dermatophytosis. As a result, we thought that cell‐mediated immunity might play a role in the acute, inflammatory type of tinea capitis and that humoral immunity might do so in the chronic, non‐inflammatory type of tinea capitis.
Clinical and Histologic Features of 64 Cases of Steatocystoma Multiplex
Authors: Cho Soyun , Chang Sung‐Eun , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: July 2014

AbstractSteatocystoma multiplex (SM) shares many clinical features and may show overlapping histopathological features with eruptive vellus hair cyst (EVHC). Clinical data and pathologic features of 64 patients with SM were evaluated in detail. Most of the cases were sporadic, with an average onset age of 26 years and distribution on the arms, chest, axillae, and neck. All cases exhibited eosinophilic cuticle and lack of granular layer, and 17–42% displayed vellus hair, hair follicles, keratin, and smooth muscle components within the cavity, in the wall, or adjacent to it. The results of this study add further evidence to the hypothesis that SM is a hamartomatous condition and that SM and EVHC are variants of one disorder which originates in the pilosebaceous duct.
Mechanisms of UV‐Induced Signal Transduction
Authors: Kulms Dagmar , Schwarz Thomas 
Published: July 2014

AbstractUltraviolet radiation (UV) causes a variety of biological effects that can be either beneficial or harmful for human health. To exert these effects on a cellular basis, UV uses a variety of signaling pathways. DNA is the major chromophore for UVB. Thus, nuclear DNA damage has been detected to be a major mediator of numerous UVB effects, and experimental reduction of DNA damage is associated with a loss of these effects. On the other hand, UV has been found to utilize molecular components within the cytoplasm or at the cell membrane for signaling. UV can directly activate cell surface receptors, kinases, and transcription factors. The nuclear and extranuclear signaling pathways are generated independently and have been recently recognized to be not mutually exclusive but to contribute to various UV effects in an independent and additive way. Further knowledge of how these signaling pathways relate to each other will certainly increase our understanding of how UV acts as a pathogen. The following review will briefly discuss current aspects of the mechanisms involved in UV‐induced signal transduction.
Ultrastructural Study of Acquired Pili Torti‐like Hair Defects Accompanying Pseudopelade
Authors: Sakamoto Fumiko , Ito Masaaki , Saito Ryuzo 
Published: July 2014

AbstractAcquired structural hair defects are caused by various physical and chemical manipulations. Plucked hairs and hair follicle biopsy specimens of pili torti‐like hairs that arose from pseudopelade scalp were studied. In scanning electron microscopy, the hair shafts had a segmental pili torti‐like appearance, accompanied by oblique or longitudinal grooves and ridges. In light microscopy, the hair follicles showed an asymmetric hair bulb and inner root sheath, and a shortened keratogenous zone within sclerosing fibrous connective tissue. In transmission electron microscopy, the numbers and thickness of the hair cuticle cells were different on the opposite sides of the hair shaft. The hair cuticle was irregularly shaped and formed asymmetric waves. The tonofilaments in the hair cortex ran almost parallel to the hair axis. From these findings, it was clear that the grooves and ridges were produced by the deformed hair cuticle and cortex, whose shapes were modulated by the asymmetric inner root sheath. This asymmetry most likely resulted from a dysfunctional dermal papilla, which was affected by fibrosis. The pili torti‐like appearance appeared to be caused by the grooves and ridges that ran obliquely on the hair shaft surface.
Proliferating Trichilemmal Cyst: Report of Two Cases, One Benign and the Other Malignant
Authors: Sethi Seema , Singh Usha Rani 
Published: July 2014

AbstractProliferating trichilemmal cyst (PTC) is a rare but morphologically distinct tumor that usually arises on the scalp of elderly women. We report two cases of PTC, one benign and the other malignant. PTCs are well circumscribed, subepidermal lesions and demonstrate a uniform histologic pattern with varying degrees of cytological atypia. Malignant proliferating trichilemmal cyst (MPTC) has features in common with benign proliferating trichilemmal cyst (BPTC), including a central area of abrupt keratinization and hyperplastic squamous epithelium forming solid areas. The diagnosis of MPTC is essentially based on histological features. The presence of a high mitotic rate, atypical mitosis, severe nuclear pleomorphism, and tumor invasion of the adjacent tissues are the essential histological features of malignancy in these unusual tumors. The therapeutic approach in malignant cases is the same as that in the treatment of BPTC: surgical removal with a wide clear margin. However, even with adequate resection, both tumors tend to recur locally.
A Japanese Case of Tinea Corporis Caused by Arthroderma benhamiae
Authors: Mochizuki Takashi , Watanabe Seiji , Kawasaki Masako , Tanabe Hiroshi , Ishizaki Hiroshi 
Published: July 2014

AbstractWe report a case of tinea corporis in Japan caused by Arthroderma benhamiae. A 53‐year‐old female scientist, who had been working on dermatophytes in a laboratory, noticed pruritic erythema on the outer corner of her left lower eyelid. She used a steroid ointment for three days, but the lesion continued to expand. When she visited our clinic, the erythema was 15 mm in diameter and clearly demarcated with a slightly depressed center. A scale from the periphery of the erythema was positive with direct KOH examination, and T. mentagrophytes was isolated from the lesion. The erythema was successfully treated with topical application of butenafine hydrochloride. The isolate was mated with a (+) strain of the Americano‐European race of A. benhamiae. Using the most sensitive molecular typing method, restriction exzyme analysis of the non‐transcribed spacer region of the ribosomal DNA, the restriction profile of the isolate was the same as that of strains used in her laboratory but different from those of any Japanese isolates associated with pet animals. The results suggest that the patient became infected during her experiment.
Dapsone in Behçet's Disease: A Double‐Blind, Placebo‐Controlled, Cross‐Over Study
Authors: Sharquie Khalifa E. , Najim Rafid A. , Abu‐Raghif Ahmed R. 
Published: July 2014

AbstractThe study was designed to investigate the effects of dapsone in the treatment of mucocutaneous manifestations of Behçet's disease and the possible prophylactic role of dapsone in a double blind/placebo controlled clinical trial. Twenty patients diagnosed according to the International Study Group criteria as Behçet's disease were included in the study. Patients were randomly allocated to receive either dapsone 100 mg daily or placebo for three months in a double‐blind manner. After three months, patients were crossed over and followed for a further three months. Patients were followed up in each visit by assessing the number, size, duration and frequency of oral and genital ulcers, other cutaneous manifestations, and systemic manifestations of the disease. A pathergy test was done on each visit. Laboratory investigations included hemoglobin concentration, white blood cell count, ESR, and C‐reactive protein. In dapsone‐treated patients, there were significant reductions in the oral and genital ulcer parameters as well as the incidence of other cutanous and systemic manifestations. In the placebo‐treated group, there were no significant changes in these parameters. The pathergy test result as well as those of other laboratory tests were all decreased in the dapsone‐treated group. Although this study was a small scale study, it shows that dapsone was effective in treatment of mucocutaneous manifestations of Behçet's disease and possibly in prophylaxis against systemic manifestations of the disease. This result should lead to a larger scale study with a longer duration of follow‐up.
Activation of Mast Cells within a Tumor of Angiosarcoma: Ultrastructural Study of Five Cases
Authors: Demitsu Toshio , Inoue Tae , Kakurai Maki , Kiyosawa Tomoharu , Yoneda Kozo , Manabe Motomu 
Published: July 2014

AbstractThe accumulation of mast cells around tumors is a well‐recognized phenomenon in a number of malignancies, including basal cell carcinoma, melanoma, and breast cancer. However, little information exists regarding mast cells within tumor nests. To clarify the role of mast cells infiltrating in skin cancers, we examined the morphological features of mast cells within tumors of five cases of angiosarcoma, including two patients with Stewart‐Treves syndrome, by electron microscopy. In light microscopy, mast cells were observed within tumor nests at various densities and exhibited weak staining intensity with toluidine blue. By electron microscopy, most of the tumor‐infiltrating mast cells exhibited anaphylactic or piecemeal degranulation, indicating that the mast cells had been activated in situ. Some mast cells were noted in close apposition to tumor cells, suggesting the existence of direct cell‐to‐cell interactions. Tumor cells adjacent to mast cells showed no degenerative changes. In conclusion, these results suggest that careful histologic examination in combination with electron microscopy should enable us to identify more mast cells within cancer lesions with greater sensitivity than in a number of prior reports. Furthermore, the close proximity of mast cells and surrounding tumor cells suggests some biologically significant role of mast cells in the development of angiosarcoma, including tumor growth as well as host immunity and stromal reaction.
Onion Juice (Allium cepa L.), A New Topical Treatment for Alopecia Areata
Authors: Sharquie Khalifa E. , Al‐Obaidi Hala K. 
Published: July 2014

AbstractAlopecia areata is a patchy, non‐scarring hair loss condition. Any hair‐bearing surface may be involved, and different modalities of treatment have been used to induce hair re‐growth. This study was designed to test the effectiveness of topical crude onion juice in the treatment of patchy alopecia areata in comparison with tap water. The patients were divided into two groups. The first group [onion‐juice treated] consisted of 23 patients, 16 males (69.5%) and 7 females (30.5%). Their ages ranged between 5–42 years with a mean of 22.7 years. The second group [control; tap‐water‐treated] consisted of 15 patients, 8 males (53.3%) and 7 females (46.6%). Their ages ranged between 3–35 years with a mean of 18.3 years. The two groups were advised to apply the treatment twice daily for two months. Re‐growth of terminal coarse hairs started after two weeks of treatment with crude onion juice. At four weeks, hair re‐growth was seen in 17 patients (73.9%), and, at six weeks, the hair re‐growth was observed in 20 patients (86.9%) and was significantly higher among males (93.7%) compared to females (71.4%) P<0.0001. In the tap‐water treated‐control group, hair re‐growth was apparent in only 2 patients (13%) at 8 weeks of treatment with no sex difference. The present study showed that the use of crude onion juice gave significantly higher results with regard to hair re‐growth than did tap water (P<0.0001), and that it can be an effective topical therapy for patchy alopecia areata.
Our Experience with Aplasia Cutis Congenita
Authors: Çaksen Hüseyin , Kurtoğlu Selim 
Published: July 2014

AbstractAplasia cutis congenita is a rare disorder characterized by developmental absence of skin on the scalp as multiple or solitary, noninflammatory, well demarcated, oval or circular 1‐ to 2‐cm ulcers. The disease may be isolated or associated with anomalies of the skin, eyes, ear‐nose‐neck and limbs, developmental defects of the cardiovascular, gastrointestinal, genitourinary and central nervous systems, and malformation syndromes such as chromosomal abnormalities, Adams‐Oliver syndrome, Bart's syndrome, and Johanson‐Bilzzard syndrome. In this article, five newborn infants with aplasia cutis congenita (one associated with Adams‐Oliver syndrome and another concomitant with Bart's syndrome) are reported because of their rare presentation in the literature.
Blood Thiols and Malondialdehyde Levels in Psoriasis
Authors: Relhan Vineet , Gupta Sunil K. , Dayal Surabhi , Pandey Rajesh , Lal Harbans 
Published: July 2014

AbstractForty patients with psoriasis and forty healthy controls were enrolled to study the levels of total blood thiols (an important part of the body's antioxidant defence system) and plasma malondialdehyde (a lipid peroxidation product). The levels of total blood thiols in psoriatic patients in the acute phase were significantly lower than those in controls, but total blood thiol levels in psoriatic patients in the remission phase were not significantly different from those in controls. There was a significant difference between levels of total blood thiols of patients in the acute phase and in remission. The levels of plasma MDA were significantly raised in psoriatic patients in the acute phase as compared to those in controls and in patients in remission. The differences in levels of plasma MDA were not significant between control subjects and patients in remission. These findings suggest a role of oxidative stress in the etiopathogenesis of psoriasis.
Familial Amyloidosis Cutis Dyschromica: Six Cases from Three Families
Authors: Choonhakarn Charoen , Wittayachanyapong iporn 
Published: July 2014

AbstractAmyloidosis cutis dyschromica, a rare form of primary cutaneous amyloidosis requiring histopathological confirmation, is characterized by generalized, asymptomatic hyperpigmentation intermingled with several hypopigmented spots without papulation, atrophy, and telangiectasia. Its onset usually begins before puberty. We describe six patients from three families, four male and two female. The mean age at onset was 10.2 years. Although the skin eruptions had developed extensively since childhood, systemic involvement was not evident even after long‐term follow‐up. Due to its unique and characteristic features, this condition should be considered as a separate entity and differentiated from other variants of primary cutaneous amyloidosis. The familial occurrence in our report suggests a genetic causal factor in this disease.