bluuebunny/crossref_metadata_2025_split huggingface dataset:
KM04416 suppressed lung adenocarcinoma progression by promoting immune infiltration
Authors: Lin Yalan , Wu Weijing , Lin Huihuang , Chen Shiyuan , Lv Huiying , Chen Shuchao , Li Chuzhao , Wang Xinwen , Chen Yunfeng 
Published: July 2024

Abstract
Objectives
Lung adenocarcinoma (LUAD) is a malignant tumor originating from the bronchial mucosa or glands of the lung, with the fastest increasing morbidity and mortality. Therefore, the prognosis of lung cancer remains poor. Glycerol-3-phosphate dehydrogenase 2 (GPD2) is a widely existing protein pattern sequence in biology and is closely related to tumor progression. The therapy values of GPD2 inhibitor in LUAD were unclear. Therefore, we aimed to analyze the therapy values of GPD2 inhibitor in LUAD.

Materials and methods
The Cancer Genome Atlas (TCGA)-LUAD database was used to analyze the expression levels of GPD2 in LUAD tissues. The relationship between GPD2 expression and LUAD patient survival was analyzed by Kaplan-Meier method. Moreover, KM04416 as a target inhibitor of GPD2 was used to further investigate the therapy value of GPD2 inhibitor in LUAD cells lines (A549 cell and H1299 cell). The TISIDB website was used to investigate the associations between GPD2 expression and immune cell infiltration in LUAD.

Results
The results showed that GPD2 is overexpressed in LUAD tissues and significantly associated with poor survival. KM04416 can suppress the progression of LUAD cells by targeting GPD2. Low expression of GPD2 is related to high infiltration of immune cells.

Conclusions
In summary, our present study found that targeting inhibition of GPD2 by KM04416 can suppress LUAD progression via adjusting immune cell infiltration.
Effects of mind-body interventions on polycystic ovary syndrome: a comprehensive meta-analysis
Authors: Zhao Kun , Nie Liuyan , Ye Xiangming , Hu Xiaoyan 
Published: July 2024

Abstract
Background
Mind-body interventions (MBI) have emerged as a potential therapeutic approach, but their effectiveness in the treatment of Polycystic Ovary Syndrome (PCOS) remains inconclusive. This study systematically evaluates the effectiveness of MBI on quality of life, anthropometry, androgen secretion, glucose, and lipid metabolism in PCOS.

Methods
A computer search was conducted across three databases: PubMed, the Cochrane Library, and EMBASE, to identify randomized controlled trials (RCTs) related to MBI for PCOS from their inception until July 2024. DerSimonian and Laird’s random-effects model and Stata 17.0 software was employed for our meta-analysis.

Results
Twelve RCTs were included. MBI significantly improved PCOSQ subscale scores, including emotional disturbances (MD: 7.75, 95% CI: 6.10 to 9.40), body hair (MD: 2.73, 95% CI: 0.54 to 4.91), menstrual problems (MD: 3.79, 95% CI: 2.89 to 4.69), and weight (MD: 1.48, 95% CI: 0.03 to 2.93). Furthermore, there was a reduction in depression levels (MD: -1.53, 95% CI: -2.93 to -0.13). Sensitivity analysis confirmed the robustness of PCOSQ-Emotional disturbances and PCOSQ-Menstrual problems, with a high GRADE level of evidence for these subscales. Secondary outcome measures, including waist-hip ratio, fasting blood glucose, and HOMA-IR exhibited statistically significant differences. Subgroup analysis revealed that obesity could influence treatment outcomes.

Conclusion
MBI can serve as an alternative therapy, modulating effect on the quality of life and depression in PCOS patients. Future well-designed, high-quality, and large-scale studies should be conducted to thoroughly assess the impact of different Mind-Body Interventions (MBI) on various PCOS phenotypes.

Trial registration
PROSPERO (CRD42023472035).
Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors
Authors: Porter Lucy L. , Simons Koen S. , Corsten Stijn , Westerhof Brigitte , Rettig Thijs C. D. , Ewalds Esther , Janssen Inge , Jacobs Crétien , van Santen Susanne , Slooter Arjen J. C. , van der Woude Margaretha C. E. , van der Hoeven Johannes G. , Zegers Marieke , van den Boogaard Mark 
Published: July 2024

Abstract
Background
With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors.

Methods
Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used. Patients admitted to the ICU in one of eleven participating hospitals between July 2016 and June 2021 were included. Outcome was defined as change in quality of life, measured using the EuroQol five-dimensional (EQ-5D-5L) questionnaire, and calculated by subtracting the EQ-5D-5L score 1 day before hospital admission from the EQ-5D-5L score 1 year post-ICU. Based on the minimal clinically important difference, a change in quality of life was defined as a change in EQ-5D-5L score of ≥ 0.08. Subgroups of patients were based on admission diagnosis.

Results
A total of 3913 (50.6%) included patients completed both baseline and follow-up questionnaires. 1 year post-ICU, patients admitted after a cerebrovascular accident, intracerebral hemorrhage, or (neuro)trauma, on average experienced a significant decrease in quality of life. Conversely, 11 other subgroups of ICU survivors reported improvements in quality of life. The largest average increase in quality of life was seen in patients admitted due to respiratory disease (mean 0.17, SD 0.38), whereas the largest average decrease was observed in trauma patients (mean -0.13, SD 0.28). However, in each of the studied 22 subgroups there were survivors who reported a significant increase in QoL and survivors who reported a significant decrease in QoL.

Conclusions
This large prospective multicenter cohort study demonstrated the diversity in long-term quality of life between, and even within, subgroups of ICU survivors. These findings emphasize the need for personalized information and post-ICU care.
Trial registration: The MONITOR-IC study was registered at ClinicalTrials.gov: NCT03246334 on August 2nd 2017.
The complexities of decision-making associated with on-demand treatment of hereditary angioedema (HAE) attacks
Authors: Betschel Stephen D. , Caballero Teresa , Jones Douglas H. , Longhurst Hilary J. , Manning Michael , van Kooten Sally , Heckmann Markus , Danese Sherry , Goga Ledia , Burnette Autumn Ford 
Published: July 2024

Abstract
Background
Hereditary angioedema (HAE) is characterized by debilitating attacks of tissue swelling in various locations. While guidelines recommend the importance of early on-demand treatment, recent data indicate that many patients delay or do not treat their attacks.

Objective
This survey aimed to investigate patient behavior and evaluate the key factors that drive on-demand treatment decision-making, as reported by those living with HAE.

Methods
People living with HAE were recruited by the US Hereditary Angioedema Association (HAEA) to complete a 20-minute online survey between September 6, and October 19, 2022.

Results
Respondents included 107 people with HAE, 80% female, 98% adults (≥ 18 years). Attack management included on-demand therapy only (50%, n = 53) or prophylaxis with on-demand therapy (50%, n = 54). Most patients (63.6%) reported that they did not carry on-demand treatment at all times when away from home. The most common reason for not carrying on-demand treatment when away from home was ‘prefer to treat at home’ (72.1%). Overall, 86% of respondents reported delaying on-demand treatment, despite recognizing the initial onset of an HAE attack and despite 97% of patients agreeing that it is important to recover quickly from an HAE attack. Reasons for non-treatment or treatment delay included ‘the attack is not severe enough to treat’ (91.9% and 88.0%, respectively), ‘cost of treatment’ (31.1% and 40.2%, respectively), anxiety about refilling the prescription for on-demand treatment quickly (31.1% and 37.0%, respectively), the pain (injection or burning) associated with their on-demand treatment (18.9% and 28.3%, respectively), the lack of a suitable/private area to administer on-demand treatment (17.6% and 27.2%, respectively), lack of time to prepare on-demand treatment (16.2% and 16.3%, respectively), and a ‘fear of needles’ (13% and 12.2%, respectively). Survey findings from the patient perspective revealed that when on-demand treatment was delayed, 75% experienced HAE attacks that progressed in severity, and 80% reported longer attack recovery.

Conclusions
Survey results highlight that decision-making regarding on-demand treatment in HAE is more complicated than expected. The burden associated with current parenteral on-demand therapies is often the cause of treatment delay, despite acknowledgment that delays may result in progression of HAE attacks and longer time to recovery.
Employment and mental health in the working age population: a protocol for a systematic review of longitudinal studies
Authors: Aanesen Fiona , Berg Rigmor C. , Jørgensen Ingrid Løken , Mohr Benedicte , Proper Karin , Lunde Lars-Kristian 
Published: July 2024

Abstract
Background
Employment provides economic security, a social network, and is important for self-identity. A review published by van der Noordt and colleagues in 2014 showed that employment was beneficial for depression and general mental health. However, an updated synthesis including research published in the last decade is lacking. In the planned review, we aim to update, critically assess, and synthesise the current evidence of the association between paid employment (excluding precarious employment) and common mental health outcomes (depression, anxiety, and psychological distress) among the working age population in the labour force.

Methods
We will follow recommended guidelines for conducting and reporting systematic reviews. Four electronic databases (MEDLINE, Embase, APA PsycINFO, and Web of Science) will be searched from 2012, using appropriate MeSH terms and text words related to our inclusion criteria. We will screen the records against predefined eligibility criteria, first by title and abstract using the priority screening function in EPPI-Reviewer, before proceeding to full-text screening. Only studies investigating the longitudinal relationship between employment and common mental health outcomes will be included. We will search for grey literature in OpenAlex and conduct backward and forward citation searches of included studies. The methodological quality of the included studies will be assessed using the Cochrane risk-of-bias tool (RoB 2), Risk Of Bias In Non-randomised Studies of Interventions (ROBINS-I), or the Newcastle–Ottawa scale (NOS). We will conduct a narrative review and, if possible following pre-set criteria, conduct random-effects meta-analyses to estimate the pooled effect of employment on depression, anxiety, and psychological distress, across the included studies.

Discussion
An updated review of the association between non-precarious employment and mental health outcomes is needed. In the planned review, we will assess the quality of the included studies and synthesise the results across studies to make them easily accessible to policy makers and researchers. The results from the review can be used to aid in policy decisions and guide future research priorities.

Systematic review registration
PROSPERO CRD42023405919.
Unified interpolative of a Reich-Rus-Ćirić-type contraction in relational metric space with an application
Authors: Vara Prasad Koti N. V. V. , Mishra Vinay , Mitrović Zoran D. , Santina Dania , Mlaiki Nabil 
Published: July 2024

AbstractIn this paper, we introduce the notion of unified interpolative contractions of the Reich–Rus–Ćirić type and give some results about the fixed points for these mappings in the framework of relational metric spaces. We present examples where the results of some previous research are not relevant. Also, we apply our results to solving problems related to nonlinear matrix equations, emphasizing their practical importance.
On the solutions of a nonlinear system of q-difference equations
Authors: Turan Nihan , Başarır Metin , Şahin Aynur 
Published: July 2024

AbstractIn this paper, we examine the existence and uniqueness of solutions for a system of the first-order q-difference equations with multi-point and q-integral boundary conditions using various fixed point (fp) theorems. Also, we give two examples to support our results.
Existence of positive solutions for a class of singular elliptic problems with convection term and critical exponential growth
Authors: Baraket Sami , Ben Ghorbal Anis , Figueiredo Giovany M. 
Published: July 2024

AbstractThis paper uses the Galerkin method to investigate the existence of positive solution to a class of singular elliptic problems given by $$\begin{aligned} \textstyle\begin{cases} -\Delta u= \displaystyle \frac {\lambda _{0}}{u^{\beta _{0}}} + \Lambda _{0} |\nabla u|^{\gamma _{0}}+ \frac{f_{0}(u)}{|x|^{\alpha _{0}}}+ h_{0}(x), \ \ u>0 \ \ \text{in} \ \Omega , \\ u=0 \ \text{on} \ \ \partial \Omega , \end{cases}\displaystyle \end{aligned}$$

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The algorithmic resolution of spectral-element discretization for the time-dependent Stokes problem
Authors: Ouertani Henda , Abdelwahed Mohamed 
Published: July 2024

AbstractWe consider two algorithms for the resolution of the time-dependent Stokes problem with nonstandard boundary conditions by the domain-decomposition spectral-element method. The first algorithm (Elimination method) is based on the Uzawa method by decoupling the linear system, while the second algorithm (Global inversion) is based on the overall resolution of the system by the GMRES method. A detailed implementation is proposed and some numerical tests are carried out in two and three dimensions and where the domain is multiply connected.
Existence of solution of a system of non-linear differential inclusions with non-local, integral boundary conditions via fixed points of hybrid contractions
Authors: Rashid Maliha , Shahid Lariab , Dar Fatima , Ayoob Irshad , Mlaiki Nabil 
Published: July 2024

AbstractIn the present article, we have introduced the notions of γ-admissibility for the pair of q-ROF set-valued maps and admissible hybrid q-ROF $\mathcal{Z}$
Z
-contraction. Notions introduced in the article generalizes the existing concepts in fuzzy literature. Common fixed point result for a pair of γ-admissible q-ROF mappings in b-metric spaces utilizing the introduced contraction is presented. A nontrivial example to support the obtained results is also included. As an application, we have discussed the existence of solution of system of non-linear n-th order differential inclusions with non-local and integral boundary conditions.
Describing an old trick in posterior thoracal and lumbar ımplant removal surgery: follow-up results for at least 10 years
Authors: Yilmaz Murat , Ikizoglu Ersin , Ertem Onder , Arslan Mert , Erbayraktar Serhat Resat , Yucesoy Kemal 
Published: July 2024

Abstract
Study design
Retrospective case series.

Objectives
We aimed to describe with a novel surgical approach for the removal of posterior thoracolumbar implant in patients with symptomatic failure of the implant and present our preliminary results with this method.

Methods
This retrospective, single-center study was performed in the neurosurgery department of a university hospital. Data were gathered from the medical files of 314 patients (243 women, 77.39%; 71 men, 22.61%) with symptomatic thoracolumbar implant failure that underwent implant removal operation using our novel technique between 2010 and 2020. Symptoms, radiological findings, intraoperative findings as well as clinical outcomes were evaluated.

Results
In our series, the average age was 46.5 years (range: 21–84) with a mean follow-up duration of 7 years (range: 3 months to 10 years). Preoperatively, the most common symptoms were leg pain and numbness of the lower extremity. Postoperatively, no major complications were noted. Clinical progression of symptoms was avoided by surgery in all patients, while we came across removal difficulties due to screw–screwdriver mismatch in 15 of 314 surgeries (4.78%). Our novel approach allowed successful screw removal including these challenging cases.

Conclusions
We suggest that our novel approach is a practical and effective for the removal of posterior thoracolumbar implant in cases with symptomatic failure attributed to screw–screwdriver mismatch. Further trials are warranted to assess the efficacy of this technique to overcome surgical problems associated with screw removal.
Heavy metals in dates (Phoenix dactylifera L.) collected from Medina and Dhaka City markets, and assessment of human health risk
Authors: Chamon Afrose Sultana , Parash Md. Abrar Hasin , Fahad Jannatul Islam , Hassan S. M. Nazmul , Ahmed Santo Kabir , Mushrat Maesha , Islam Nafisha , Hasan Taukir , Atiya Zarin , Mondol Md. Nadiruzzaman 
Published: July 2024

Abstract
Background
Constantly eaten foods (such as fruits, vegetables, cereal, etc.) that contain excessive concentrations of heavy metals pose a major risk to human health and deplete the food supply. The amounts of heavy metals in different date varietiies were measured after they were collected from three wholesale markets in the major cities of Dhaka, Bangladesh, and Medina. In order to look at the health risks associated with heavy metal consumption after intake of dates, the Average Daily Intake (ADI), Hazard Quotient (HQ), and Hazard Index (HI) were also calculated.

Results
Copper (Cu), Cadmium (Cd), Chromium (Cr), Iron (Fe), Lead (Pb), Manganese (Mn), Nickel (Ni), and Zinc (Zn) levels were evaluated. Several analyses of date fruit exhibited levels of Pb and Cd in different date varieties that beyond the Maximum Permissible Limit (MPL). In the majority of the samples, ADI was below the upper authorized tolerated daily consumption. The likelihood of a health risk from the regular eating of the investigated date fruits is revealed by the hazardous indexes of samples taken from New Market and Badamtali that surpassed unit value as a result of excessive air pollution brought on by greater industrial and vehicle traffic. According to the study, the majority of the analyzed heavy metals were identified in date samples and those from later samples at levels that were less harmful than the maximum acceptable threshold (MAL).

Conclusions
Some samples included higher levels of Pb and Cd. As a result, eating dates that contain more metal has a higher chance of harming your health. Additionally, it has been recommended that regular testing for heavy metals in date fruits may be useful in preventing health risks associated with eating fruits that are contaminated with heavy metals.
A Comparative Genomic Analysis of Parathyroid Adenomas and Carcinomas Harboring Heterozygous Germline CDC73 Mutations
Authors: Li Yulong , Simonds William F , Chen Haobin 
Published: July 2024

Abstract

Context
Parathyroid cancer has been linked to germline mutations of the Cell Division Cycle 73 (CDC73) gene. However, carriers harboring cancer-associated germline CDC73 mutations may develop only parathyroid adenoma or no parathyroid disease. This incomplete penetrance indicates that additional genomic events are required for parathyroid tumorigenesis.

Objective
(1) Determine the status of the second CDC73 allele in parathyroid tumors harboring germline CDC73 mutations and (2) compare the genomic landscapes between parathyroid carcinomas and adenomas.

Design
Whole-exome and RNA sequencing of 12 parathyroid tumors harboring germline CDC73 mutations (6 adenomas and 6 carcinomas) and their matched normal tissues.

Results
All 12 parathyroid tumors had gained 1 somatic event predicted to cause a complete inactivation of the second CDC73 allele. Several distinctive genomic features were identified in parathyroid carcinomas compared to adenomas, including more single nucleotide variants bearing the C &gt; G transversion and APOBEC deamination signatures, frequent mutations of the genes involved in the PI-3K/mTOR signaling, a greater number of copy number variations, and substantially more genes with altered expression. Parathyroid carcinomas also share some genomic features with adenomas. For instance, both have recurrent somatic mutations and copy number loss that impact the genes involved in T-cell receptor signaling and tumor antigen presentation, suggesting a shared strategy to evade immune surveillance.

Conclusion
Biallelic inactivation of CDC73 is essential for parathyroid tumorigenesis in carriers harboring germline mutations of this gene. Despite sharing some genomic features with adenomas, parathyroid carcinomas have more distinctive alterations in the genome, some of which may be critical for cancer formation.
DiGeorge Syndrome Diagnosed at Age 38: Challenges in Low-resource Settings and Implications of a Missed Diagnosis
Authors: Kuenstner William , Rapisuwon Suthee , Shobab Leila 
Published: July 2024

Abstract
22q11.2 deletion syndrome (22.q11.2 DS) is a genetic syndrome resulting from a microdeletion on chromosome 22. It has a diverse array of manifestations, and most cases are diagnosed early in childhood. We present the case of a 38-year-old female born in a developing country who presented to our clinic to establish care for a history of primary hypothyroidism. She was clinically and biochemically euthyroid on thyroid supplementation. She was also noted to have hypocalcemia in the setting of low PTH, for which the patient was previously prescribed calcitriol. Given a history of cleft palate, abnormal facial features, mild recurrent sinopulmonary infections, and her endocrine history (including short stature with height in the 6th percentile), genetic testing was obtained. She was diagnosed with a heterozygous whole gene deletion of the TBX1 gene. Additional genetic evaluation demonstrated a 2.6-Mb microdeleted segment of the 22a11.2 region encompassing 62 genes. The patient was referred to cardiology for evaluation of cardiac involvement given a history of tachyarrhythmia. This case highlights challenges in diagnosis and the implications of a delayed diagnosis of 22.q11.2 DS.