bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review and Adjusted Indirect Comparison Meta-Analysis of Oral Anticoagulants in Atrial Fibrillation
Authors: Baker William L. , Phung Olivia J. 
Published: August 2012

Background—
Oral anticoagulants such as apixaban, dabigatran, and rivaroxaban are alternatives to warfarin for preventing events in patients with atrial fibrillation. Direct comparative studies between agents are unavailable. Our objective was to conduct an adjusted indirect comparison meta-analysis between new oral agents in atrial fibrillation.

Methods and Results—
We searched MEDLINE and Cochrane Central through February 2012 for randomized, controlled trials in patients with atrial fibrillation evaluating apixaban, dabigatran, or rivaroxaban versus warfarin. For dabigatran, only data from the Food and Drug Administration–approved dose were included. Outcomes included the composite of stroke or systemic embolism, any stroke, and major bleeding among, others. Outcomes were initially pooled using standard random-effects methods, producing risk ratio and 95% confidence intervals. Adjusted indirect comparisons using these pooled estimates were then performed. A total of 44 733 patients from 4 studies were analyzed. Most analyses yielded no differences between agents. Dabigatran lowered risk of composite outcome (risk ratio, 0.75; 95% confidence interval, 0.57–1.00), ischemic stroke (0.67; 0.48–0.93), and hemorrhagic stroke (0.45; 0.45–0.99) versus rivaroxaban. No differences in all strokes or mortality were seen. Apixaban lowered the risk of major bleeding (0.74; 0.60–0.91) and gastrointestinal bleeding (0.58; 0.41–0.82) versus dabigatran and major bleeding versus rivaroxaban (0.68; 0.55–0.83), but increased systemic emboli versus rivaroxaban (3.86; 1.17–12.75).

Conclusions—
Significant differences in efficacy and safety parameters may exist between oral anticoagulant agents in patients with atrial fibrillation. Apixaban lowers the risk of major and gastrointestinal bleeding versus dabigatran and rivaroxaban. Dabigatran lowers the composite of stroke or systemic emboli, and ischemic stroke versus rivaroxaban. Head-to-head clinical trials are required to confirm these findings.
Learning Dependency-Based Compositional Semantics
Authors: Liang Percy , Jordan Michael I. , Klein Dan 
Published: August 2012

Suppose we want to build a system that answers a natural language question by representing its semantics as a logical forxm and computing the answer given a structured database of facts. The core part of such a system is the semantic parser that maps questions to logical forms. Semantic parsers are typically trained from examples of questions annotated with their target logical forms, but this type of annotation is expensive. Our goal is to instead learn a semantic parser from question–answer pairs, where the logical form is modeled as a latent variable. We develop a new semantic formalism, dependency-based compositional semantics (DCS) and define a log-linear distribution over DCS logical forms. The model parameters are estimated using a simple procedure that alternates between beam search and numerical optimization. On two standard semantic parsing benchmarks, we show that our system obtains comparable accuracies to even state-of-the-art systems that do require annotated logical forms.
Hypotheses for the Climax Wintertime Orographic Cloud Seeding Experiments
Authors: Grant Lewis O. 
Published: August 2012

Abstract
The hypothesis used for the initial Climax wintertime cloud seeding experiment and for subsequent Climax replication-type experiments are described and briefly discussed. More recent physical studies of Colorado orographic clouds and seeding hypotheses are briefly summarized. These later tests and studies of orographic cloud seeding hypotheses emphasized direct and remotely sensed cloud and precipitation measurements utilizing instrumentation and modeling capabilities not available during the Climax statistical experiments. The conclusions suggested from the hypothesis testing, considering both the statistical experiments and the later physical studies, are summarized.
A Comparison of Winter Orographic Storms over the San Juan Mountains and the Sierra Nevada
Authors: Marwitz John 
Published: August 2012

Abstract
The winter orographic storms over the San Juan Mountains and the Sierra Nevada are compared. The topography of the San Juans is complex while the Sierra barrier is comparatively simple. The barrier jet is well developed upwind of the Sierra Nevada and its development is restricted upwind of the San Juans. The major difference between the storms on the two barriers is that the Sierra Nevada storms are typically maritime while the San Juan storms are continental. The implications for seeding are discussed.
Performance Evaluation for a Lightning Location System Based on Observations of Artificially Triggered Lightning and Natural Lightning Flashes
Authors: Chen Luwen , Zhang Yijun , Lu Weitao , Zheng Dong , Zhang Yang , Chen Shaodong , Huang Zhihui 
Published: August 2012

Abstract
Performance evaluation for the lightning location system (LLS) of the power grid in Guangdong Province, China, was conducted based on observation data of the triggered lightning flashes obtained in Conghua, Guangzhou, during 2007–11 and natural lightning flashes to tall structures obtained in Guangzhou during 2009–11. The results show that the flash detection efficiency and stroke detection efficiency were about 94% (58/62) and 60% (97/162), respectively. The arithmetic mean and median values for location error were estimated to be about 710 and 489 m, respectively, when more than two reporting sensors were involved in the location retrieval (based on 87 samples). After eliminating one obviously abnormal sample, the absolute percentage errors of peak current estimation were within 0.4%–42%, with arithmetic mean and median values of about 16.3% and 19.1%, respectively (based on 21 samples).
Electrically Active Convection in Tropical Easterly Waves and Implications for Tropical Cyclogenesis in the Atlantic and East Pacific
Authors: Leppert Kenneth D. , Petersen Walter A. , Cecil Daniel J. 
Published: August 2012

Abstract
In this study, the authors investigated the characteristics of tropical easterly wave convection and the possible implications of convective structure on tropical cyclogenesis and intensification over the Atlantic Ocean and the east Pacific Ocean. Easterly waves were partitioned into northerly, southerly, trough, and ridge phases based on the 700-hPa meridional wind from the National Centers for Environmental Prediction–National Center for Atmospheric Research reanalysis dataset. Waves were subsequently divided according to whether they did or did not develop tropical cyclones (i.e., developing and nondeveloping, respectively), and developing waves were further subdivided according to development location. Finally, composites as a function of wave phase and category were created using data from the Tropical Rainfall Measuring Mission (TRMM) Microwave Imager, Precipitation Radar (PR), and Lightning Imaging Sensor as well as infrared (IR) brightness temperature data from the NASA global-merged IR brightness temperature dataset.
Results suggest that the convective characteristics that best distinguish developing from nondeveloping waves vary according to where developing waves spawn tropical cyclones. For waves that develop a cyclone in the Atlantic basin, coverage by IR brightness temperatures ≤240 and ≤210 K provide the best distinction between developing and nondeveloping waves. In contrast, several variables provide a significant distinction between nondeveloping waves and waves that develop cyclones over the east Pacific as these waves near their genesis location including IR threshold coverage, lightning flash rates, and low-level (&lt;4.5 km) PR reflectivity. Results of this study may be used to help develop thresholds to better distinguish developing from nondeveloping waves and serve as another aid for tropical cyclogenesis forecasting.
Practical Ways to Facilitate Ergonomics Improvements in Occupational Health Practice
Authors: Kogi Kazutaka 
Published: August 2012

Objective: Recent advances in participatory pro-grams for improving workplace conditions are discussed to examine practical ways to facilitate ergonomics improvements. Background: Participatory training programs are gaining importance, particularly in promoting occupational health and safety in small-scale workplaces. These pro-grams have led to many improvements that can reduce work-related risks in varied situations. Materials: Recent experiences in participatory action–oriented training programs in small workplaces and agriculture are reviewed. The emphasis of the review is on training steps, types of improvements achieved, and the use of action tools by trainers and training participants. Results: Immediate improvements in multiple technical areas are targeted, including materials handling, workstation design, physical environment, welfare facilities, and work organization. In facilitating ergonomics improvements in each local situation, it is important to focus on (a) building on local good practices; (b) applying practical, simple improvements that apply the basic principles of ergonomics; and (c) developing action-oriented toolkits for direct use by workers and managers. This facilitation process is effective when locally designed action toolkits are used by trainers, including local good examples, action checklists, and illustrated how-to guides. Intervention studies demonstrate the effectiveness of participatory steps that use these toolkits in promoting good practices and reducing work-related risks. Conclusion: In facilitating ergonomics improvements in small-scale workplaces, it is important to focus on practical, low-cost improvements that build on local good practices. The use of action-oriented toolkits reflecting basic ergonomics principles is helpful. The promotion of the intercountry networking of positive experiences in participatory training is suggested.
Outcome of Pediatric Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation
Authors: Aspesberro François , Guthrie Katherine A. , Woolfrey Ann E. , Brogan Thomas V. , Roberts Joan S. 
Published: August 2012

Purpose: To assess the risk factors for intensive care unit admission among children receiving hematopoietic stem cell transplantation (HSCT) and to test the hypothesis that multiple organ failure (MOF) increases the odds of death among HSCT patients who receive mechanical ventilation (MV). Methods: The chart of all consecutive HSCTs at Seattle Children’s Hospital and pediatric HSCT patients admitted to the pediatric critical care unit of a tertiary care pediatric hospital from January 2000 to September 2006 were reviewed retrospectively. Results: Charts of 266 HSCT patients were reviewed. Nonmalignant disease compared to hematologic malignancy, acute graft versus host disease grades III and IV, and second transplant increased the odds of pediatric intensive care unit admission. Among patients receiving MV for >24 hours, 9 (25%) survived for 6 months, while 8 patients (22%) were long-term survivors with a median follow-up time of 3.6 years, a significant improvement compared to a long-term survival of 7% (odds ratio 0.25, 95% confidence intervals: 0.09-0.72, P = .01) reported in a previously published cohort of pediatric HSCT patients at the same institution from 1983 to 1996. Cardiovascular failure, duration of MV for greater than 1 week, and prolonged receipt of continuous renal replacement therapy (CRRT) increased the risk of mortality. Conclusions: Six-month survival of pediatric HSCT patients was 25% and the odds of death were increased by cardiovascular failure but not by MOF. Receipt of mechanical support (ventilation, CRRT) or cardiovascular support (inotropic agents) decreased the likelihood of long-term survival.
Differential Expression of Cancer-Related Proteins in Paired Breast Milk Samples from Women with Breast Cancer
Authors: Arcaro Kathleen F. , Browne Eva P. , Qin Wenyi , Zhang Ke , Anderton Douglas L. , Sauter Edward R. 
Published: August 2012

Background: Breast cancer risk increases during pregnancy and remains elevated for a number of years thereafter. Cancer-associated proteins that are secreted into breast milk may provide a means to detect cancer in the lactating breast or to assess future breast cancer risk. Objective: To determine whether proteins linked to breast cancer would be differentially expressed in matched (both breasts from each participant) human milk samples collected from women with unilateral breast cancer. Methods: Five cancer-associated proteins (basic fibroblast growth factor [bFGF], YKL-40, neutrophil gelatinase-associated lipocalin, and transforming growth factor β1 and β2) were analyzed in milk provided by 5 lactating women, 4 of whom were known to have cancer in 1 breast (and the opposite breast clinically disease free) at the time of milk collection and 1 who developed breast cancer 2 years after milk collection. Results: Expression was significantly higher for TGFβ2 ( P = .03) and bFGF ( P =.03) in the breasts with cancer. Conclusion: These proteins may play a role in assessing a woman’s risk of pregnancy-associated breast cancer. Because of variable protein concentration among patients and the limited sample size, the results are considered preliminary.
Chylous Ascites Complicating Elective Abdominal Aortic Aneurysm Repair
Authors: Barakat Hashem M. , Shahin Yousef , McCollum Peter 
Published: August 2012

Introduction: Chylous ascitis is a rare complication of abdominal aortic aneurysm (AAA) surgery with only 38 cases reported since the early 70s. Due to their anatomical relation with the abdominal aorta, cisterna chyli injury is more common following open AAA repairs when compared to other surgeries; 81% of all postsurgical chylous ascites reported. Case presentation: We present a case of severe chylous ascitis following elective AAA repair in a 76-year-old caucasian male who gradually developed abdominal distension following discharge. A conservative approach was followed by a peritoneovenous shunt insertion, but this had no clinical benefit. The site of chyle leak was identified and ligated at relaparatomy to eventually resolve his ascitis. Conclusion: Many reports in literature demonstrate successful conservative measures and highlight the importance of nutritional status in the course of persistent postoperative chylous ascitis. In our experience, complete resolution only came after relaparatomy and repair of leaking lymphatics.
Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists
Authors: Chapple Iain LC , Matthews John B , Wright Helen J , Scott Ann E , Griffiths Helen R , Grant Melissa M 
Published: August 2012

Periodontitis, a ubiquitous chronic inflammatory disease, is associated with reduced antioxidant defences and neutrophil hyperactivity in terms of reactive oxygen species (ROS) generation. Its phenotype is thus characterized by oxidative stress. We have determined the effect of antioxidant micronutrients ascorbate and α-tocopherol on neutrophil ROS generation. Peripheral neutrophils from periodontally-healthy individuals ( n = 20) were challenged with phorbol myristate acetate, IgG-opsonised Staphylococcus aureus, Fusobacterium nucleatum or PBS in the presence and absence of micronutrients (50 µM). Total and extracellular ROS were measured by luminol and isoluminol chemiluminescence respectively. Total and extracellular unstimulated, baseline ROS generation was unaffected by α-tocopherol, but inhibited by ascorbate and a combination of both micronutrients. Fcγ-receptor (Fcγ-R)-stimulated total or extracellular ROS generation was not affected by the presence of individual micronutrients. However, the combination significantly reduced extracellular FcγR-stimulated ROS release. Neither micronutrient inhibited TLR-stimulated total ROS, but the combination caused inhibition. Ascorbate and the micronutrient combination, but not α-tocopherol, inhibited extracellular ROS release by TLR-stimulated cells. Such micronutrient effects in vivo could be beneficial in reducing collateral tissue damage in chronic inflammatory diseases, such as periodontitis, while retaining immune-mediated neutrophil function.
Effects of asthma severity, exacerbations and oral corticosteroids on perinatal outcomes
Authors: Namazy Jennifer A. , Murphy Vanessa E. , Powell Heather , Gibson Peter G. , Chambers Christina , Schatz Michael 
Published: August 2012

This systematic review and meta-analysis sought to investigate whether asthma exacerbations, oral corticosteroid use or asthma severity are associated with prematurity and intrauterine growth restriction.Cohort studies published between 1975 and March 11, 2012 were considered for inclusion. 138 publications were identified for possible inclusion, and nine papers met the inclusion criteria, by reporting perinatal outcomes of interest (low birth weight, <2500 g), pre-term birth (<37 weeks gestation unless otherwise stated) and small for gestational age (<10th percentile for gestational age and sex) in groups of asthmatic patients stratified by history of exacerbations, oral corticosteroid use or asthma severity.Maternal asthma exacerbations and oral corticosteroid use had a significant effect on outcomes, including low birth weight (RR 3.02, 95% CI 1.87–4.89 and RR 1.41, 95% CI 1.04–1.93, respectively) and pre-term delivery (RR 1.54, 95% CI 0.89–2.69 and RR 1.51, 95% CI 1.15–1.98, respectively). Moderate-to-severe asthma during pregnancy was associated with an increased risk of small for gestational age (RR 1.24, 95% CI 1.15–1.35) and low birth weight (RR 1.15, 95% CI 1.05–1.26) infants.These data suggest that asthma exacerbations, oral corticosteroid use or asthma severity defined as moderate-to-severe may be associated with pre-term delivery, low birth weight, and small for gestational age infants. Further studies on the effect of maternal asthma control on perinatal outcomes are warranted.
Improving mapping and SNP-calling performance in multiplexed targeted next-generation sequencing
Authors: ElSharawy Abdou , Forster Michael , Schracke Nadine , Keller Andreas , Thomsen Ingo , Petersen Britt-Sabina , Stade Björn , Stähler Peer , Schreiber Stefan , Rosenstiel Philip , Franke Andre 
Published: August 2012

Abstract

Background
Compared to classical genotyping, targeted next-generation sequencing (t NGS) can be custom-designed to interrogate entire genomic regions of interest, in order to detect novel as well as known variants. To bring down the per-sample cost, one approach is to pool barcoded NGS libraries before sample enrichment. Still, we lack a complete understanding of how this multiplexed t NGS approach and the varying performance of the ever-evolving analytical tools can affect the quality of variant discovery. Therefore, we evaluated the impact of different software tools and analytical approaches on the discovery of single nucleotide polymorphisms (SNPs) in multiplexed t NGS data. To generate our own test model, we combined a sequence capture method with NGS in three experimental stages of increasing complexity (E. coli genes, multiplexed E. coli, and multiplexed HapMap BRCA1/2 regions).

Results
We successfully enriched barcoded NGS libraries instead of genomic DNA, achieving reproducible coverage profiles (Pearson correlation coefficients of up to 0.99) across multiplexed samples, with <10% strand bias. However, the SNP calling quality was substantially affected by the choice of tools and mapping strategy. With the aim of reducing computational requirements, we compared conventional whole-genome mapping and SNP-calling with a new faster approach: target-region mapping with subsequent ‘read-backmapping’ to the whole genome to reduce the false detection rate. Consequently, we developed a combined mapping pipeline, which includes standard tools (BWA, SAMtools, etc.), and tested it on public HiSeq2000 exome data from the 1000 Genomes Project. Our pipeline saved 12 hours of run time per Hiseq2000 exome sample and detected ~5% more SNPs than the conventional whole genome approach. This suggests that more potential novel SNPs may be discovered using both approaches than with just the conventional approach.

Conclusions
We recommend applying our general ‘two-step’ mapping approach for more efficient SNP discovery in t NGS. Our study has also shown the benefit of computing inter-sample SNP-concordances and inspecting read alignments in order to attain more confident results.
Isorhamnetin 3-O-robinobioside from Nitraria retusa leaves enhance antioxidant and antigenotoxic activity in human chronic myelogenous leukemia cell line K562
Authors: Boubaker Jihed , Sghaier Mohammed Ben , Skandrani Ines , Ghedira Kamel , Chekir-Ghedira Leila 
Published: August 2012

Abstract

Background
In this report, the isorhamnetin 3-o-robinobioside and its original extract, the ethyl acetate extract, from Nitraria retusa leaves, were evaluated for their ability to induce antioxidant and antigenotoxic effects in human chronic myelogenous leukemia cell line.

Methods

Nitraria retusa products properties were carried out by firstly evaluating their effects against lipid peroxidation induced by H2O2, using the thiobarbituric acid reactive substances species (TBARS) assay, and proceeding to the assay of cellular antioxidant activity, then doing the comet assay.

Results
The isorhamnetin 3-o-robinobioside showed a protective effect against lipid peroxidation induced by H2O2. The same natural compound and ethyl acetate extract inhibited oxidation induced by 2,2′-azobis (2-amidinopropane) dihydrochloride in human chronic myelogenous leukemia cells with respectively 50% inhibitory concentration values of 0.225 mg/ml and 0.31 mg/ml, reflecting a significant antioxidant potential. The same two products inhibited the genotoxicity induced by hydroxyl radicals in the same human cell line (by 77.77% at a concentration of 800 μg/ml and by 80.55% at a concentration of 1000 μg/ml respectively).

Conclusions
The i sorhamnetin 3- o-robinobioside and its original extract, the ethyl acetate extract, from Nitraria retusa leaves, have a great antioxidant and antigenotoxic potential on human chronic myelogenous leukemia cell line K562.