bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and characteristics of rapid eye movement sleep behaviour disorder in adults with migraine: a cross‐sectional screening study
Authors: Lange Kristin Sophie , Mecklenburg Jasper , Overeem Lucas Hendrik , Fitzek Mira Pauline , Siebert Anke , Steinicke Maureen , Triller Paul , Neeb Lars , Dreier Jens Peter , Kondziella Daniel , Reuter Uwe , Raffaelli Bianca 
Published: July 2024

AbstractBackground and purposeMigraine and sleep disorders share a bidirectional relationship, but little is known about the specific association between migraine and rapid eye movement (REM) sleep behaviour disorder (RBD). The aim was to assess the prevalence of RBD and associated clinical characteristics in adults with migraine.MethodsThis analysis is part of a cross‐sectional survey study conducted at the Headache Centre of the Charité—Universitätsmedizin Berlin between August 2020 and March 2023. At the end of their regular medical consultation, patients with migraine filled out (1) the validated RBD Screening Questionnaire (RBDSQ), (2) a questionnaire on REM sleep intrusions and (3) the Depression, Anxiety and Stress Scale 21. The primary endpoint was the percentage of patients with a positive RBD screening. A multivariate analysis was performed to identify characteristics independently associated with features of RBD.ResultsA total of 751 patients (44.1 ± 13.2 years; 87.4% female) with complete RBDSQ were included in this analysis, of which 443 (58.9%) screened positive for RBD. In multivariate analysis, a positive screening for RBD was associated with younger age (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.8–0.9 per 10‐year increase; p = 0.005) and with features suggestive of REM sleep intrusions (OR 4.3, 95% CI 1.8–10.4; p = 0.001). Migraine aura remained in the model without reaching statistical significance (OR 1.3, 95% CI 0.9–1.8; p = 0.079).DiscussionSymptoms of RBD are frequent in adults with migraine. Further studies including polysomnography are required to confirm this association, and to explore potential common pathophysiological mechanisms.
Structural investigation of lithium bismuth borate glasses through Raman and infrared spectroscopies
Authors: Tsekrekas Elizabeth M. , Carretto Sophia J. , Möncke Doris C. , Clare Alexis G. 
Published: July 2024

AbstractThe structure of lithium bismuth borate glasses in the compositional series xBi2O3–25Li2O–(75 − x) B2O3 was studied with the use of Raman and infrared (IR) spectroscopies. Transparent glasses formed between x = 0 and 55, whereas glass–ceramics formed between x = 60 and 75 mol% Bi2O3. Structural investigation on the borate network showed that the glasses were undermodified at high Bi2O3 compositions with metaborate, pyroborate, and orthoborate triangles and tetrahedra being present past the stoichiometric orthoborate compositions (O/B = 3). Bi2O3 was found to participate in the glass as both a network former and modifier, as observed in the Raman and IR spectra. Optical absorption spectra of the glasses show a redshift of the absorption edge with increased Bi2O3. Optical, thermal, and physical properties of the glasses were examined and correlated to the structural evolution.
Ulcerative erythematous papules and plaques on the face and lower legs of a man living with HIV: a clinicopathological challenge
Authors: McKenzie Ning C. , Hickey Matthew D. , De la Sancha Carlo , Coates Sarah J. , Leslie Kieron S. 
Published: July 2024

AbstractA 44‐year‐old male presented with a 2‐month history of erythematous ulcerative papules and plaques on the scalp, face, and bilateral lower legs. He had a 5‐year history of well‐controlled HIV on antiretroviral therapy and recurrent syphilis infections. His face had violaceous plaques, while bilateral ankles and calves had ulcerative lesions with necrotic centers and purple borders. The morphologies clinically mimicked pyoderma gangrenosum on the lower extremities and cutaneous lymphoma on the face. Biopsy and reactive rapid plasma reagin confirmed a diagnosis of lues maligna, and the patient was successfully treated with penicillin G benzathine.
Diaspora and development: The IOM's role in diaspora mapping in Bosnia and Herzegovina
Authors: Karabegović Dženeta 
Published: July 2024

AbstractDiaspora governance strategies are part of an increasingly vibrant academic and policy debate. International organisations play a significant role in promoting diaspora institutions, collaborating with home states, diaspora communities, and other stakeholders. In post‐conflict states, the involvement, and evolving roles of international organisations, among a variety of actors in diaspora institution building, is implicit but has been underresearched. This article analyses a diaspora mapping exercise led by the IOM to demonstrate how an institutional logics perspective can help to better understand how such processes unfold. Taking an organisational perspective, it sheds light on the interplay among international organisations, state agencies, local government, and individual actors in diaspora and development. By focusing on Bosnia and Herzegovina, the study offers insights into the challenges and opportunities in diaspora engagement in post‐conflict countries. It underscores the need for further research and the long‐term implications of international organisations' efforts in diaspora development programs and diaspora governance.
Real‐world experience of immune checkpoint inhibitors in patients with solid tumours in the Top End of the Northern Territory, Australia from 2016 to 2021: a retrospective observational cohort study
Authors: Miller Abigail R. , Balino Aries , Tun Min Sandy , Downton Teesha , Karanth Narayan V. , Backen Alison , Charakidis Michail 
Published: July 2024

AbstractBackgroundUse of immune checkpoint inhibitors is growing, but clinical trial data may not apply to Indigenous patients or patients living in remote areas.AimsTo provide real‐world incidence of immune‐related adverse events (irAE) in the Top End of the Northern Territory and compare incidence between demographic subgroups.MethodsThis retrospective, observational, cohort study collected data from electronic records of patients living in the Top End with solid organ cancer treated with immunotherapy between January 2016 and December 2021. The primary outcome was cumulative incidence of any‐grade and severe irAE. Secondary outcomes were overall survival, treatment duration and reason for treatment discontinuation.ResultsTwo hundred and twenty‐six patients received immunotherapy. Forty‐eight (21%) lived in a remote or very remote area, and 36 (16%) were Indigenous. Cumulative incidence of any‐grade irAE was 54% (122/226 patients); incidence of severe irAE was 26% (59/226 patients). Rates were similar between Indigenous and non‐Indigenous patients of any‐grade (42% vs 56%, P = 0.11) and severe (11% vs 18%, P = 0.29) irAE. However, Indigenous patients had shorter treatment duration, more frequently discontinued treatment due to patient preference and appeared to have shorter median overall survival than non‐Indigenous patients (17.1 vs 30.4 months; hazard ratio (HR) = 1.5, 95% confidence interval (CI) = 0.92–2.66). There was no difference in mortality between remote and urban patients (median overall survival 27.5 vs 30.2 months; HR = 1.1, 95% CI = 0.7–1.7).ConclusionsRates of irAE in our cohort are comparable to those in the published literature. There was no significant difference in any‐grade or severe irAE incidence observed between Indigenous and non‐Indigenous patients.
Psychosocial and emotional management of work experience in palliative care nurses: A qualitative exploration
Authors: Espejo‐Fernández Victoria , Martínez‐Angulo Pablo 
Published: July 2024

AbstractBackgroundPalliative care, a crucial aspect of healthcare, faces challenges in psychosocial and emotional management among nurses. With an increasing need for palliative services globally, addressing the emotional well‐being of nurses becomes pivotal.AimTo explore nurses' psychosocial and emotional work experiences in a palliative care department. The focus is on understanding the challenges, identifying coping strategies, and assessing the impact on professional and private life when facing those experiences.MethodsA phenomenologic‐hermeneutical study involving semi‐structured interviews was conducted to comprehend the lived experiences of ten nurses working in a hospital's palliative care department in Spain. Hermeneutic analysis was employed to extract patterns and insights from their experiences. The COREQ checklist was used to report this study.FindingsPalliative care nurses perceived insufficient preparation in emotional management, grappling with complex family interactions and unique work dynamics. They highlighted the significance of self‐protection strategies, experience, clinical sessions, and external resources. Limited training in emotional resilience and challenges posed by the COVID‐19 pandemic emerged as organisational barriers. Nurses expressed a desire for enhanced training and resources.ConclusionThe study uncovered a deficiency in the emotional preparedness of palliative care nurses, impacting their professional and personal lives. Despite positive aspects, the emotional toll necessitates attention and intervention.Implications for nursing policyComprehensive emotional training for palliative care nurses, addressing barriers, providing resources, and acknowledging emotional labour is necessary. Reinstating paused training sessions and considering specific challenges like those posed by the pandemic are vital. Supporting nurses in their professional and private lives is crucial for sustaining quality care in palliative care departments.
Time spent on activities that can be delegated and reasons for not delegating among acute care nurses: A mixed‐methods study
Authors: Conti Alessio , Gonella Silvia , Berardinelli Daniela , Dimonte Valerio , Campagna Sara 
Published: July 2024

AbstractAimTo describe the activities nurses perceived to be delegable to other staff (delegable activities) in order to estimate the time nurses spend on delegable activities and explore nurses' reasons for not delegating these activities.DesignMixed‐methods explanatory sequential.MethodsIn total, 236 nurses from 27 medical and surgical wards of five hospitals in northern Italy completed a web‐based survey during a single shift between June and July 2022. Minutes spent on delegable activities, staff member to whom participants could have delegated and reason(s) for not delegating were reported. Chief nurses provided specific wards' characteristics using a paper‐and‐pencil questionnaire. Twenty semi‐structured interviews were conducted to explore delegable activities and reasons for not delegating. Quantitative and qualitative results were merged using joint displays.ResultsParticipants spent approximately one‐quarter of their time performing delegable activities, mainly delegable to nurse aides or nurse clerks, and performed due to a lack/shortage of staff or their concurrent participation in other activities. Participants recognized that activities requiring clinical assessment and decision‐making skills cannot be delegated, whereas technical activities and indirect care should be delegated. Organizational, structural and cultural factors, as well as patient characteristics, available staff and experience affected delegation, leading nurses to perform delegable activities to ensure patient care.ConclusionNurses spend a considerable part of their time on delegable activities due to a lack of staff or support services and suboptimal organization, which could be addressed by optimal staff management, but also to the complexity of the contexts, including individual and cultural factors that should be addressed through policy interventions.ImpactThis study estimates the time nurses spend on delegable activities in acute care settings. Our findings highlighted the reasons that sustain the decision not to delegate that policymakers, healthcare managers, and nurse educators should consider to promote nurses' delegation skills.Reporting MethodsMMR checklist.Patient/Public ContributionNone.
Association between high‐density mapping of atypical atrial flutter, clinical outcomes and healthcare utilization
Authors: Sink Joshua , Culler Kasen , Uppalapati Lakshmi , Lancki Nicola , Peigh Graham , Lohrmann Graham , Elsayed Mahmoud , Carneiro Herman , Baman Jayson , Pfenniger Anna , Patil Kaustubha D. , Verma Nishant , Arora Rishi , Kim Susan S. , Chicos Alexandru B. , Lin Albert C. , Knight Bradley P. , Passman Rod S. 
Published: July 2024

AbstractBackgroundSuccess of atypical atrial flutter (AAFL) ablation has historically been limited by difficulty mapping the complex re‐entrant circuits involved. While high‐density (HD) mapping has become commonplace in clinical practice, there are limited data on outcomes of HD versus non‐HD mapping for AAFL ablation.ObjectiveTo compare clinical outcomes and healthcare utilization using HD mapping versus non‐HD mapping for AAFL ablation.MethodsRetrospective analysis of all AAFL procedures between 2005 and 2022 at an academic medical center was conducted. Procedures utilizing a 16‐electrode HD Grid catheter and Precision mapping system were compared to procedures using prior generation 10–20 electrode spiral catheters and the Velocity system (Abbott, IL). Cox regression models and Poisson regression models were utilized to examine procedural and healthcare utilization outcomes. Models were adjusted for left ventricular ejection fraction, CHA2DS2‐VASc, and history of prior ablation.ResultsThere were 108 patients (62% HD mapping) included in the analysis. Baseline clinical characteristics were similar between groups. Use of HD mapping was associated with a higher rate of AAFL circuit delineation (92.5% vs. 76%; p = .014) and a greater adjusted procedure success rate, defined as non‐inducibility at procedure end, (aRR (95% CI) 1.26 (1.02–1.55) p = .035) than non‐HD mapping. HD mapping was also associated with a lower rate of ED visits (aIRR (95% CI) 0.32 (0.14–0.71); p = .007) and hospitalizations (aIRR (95% CI) 0.32 (0.14–0.68); p = .004) for AF/AFL/HF through 1 year. While there was a lower rate of recurrent AFL through 1 year among HD mapping cases (aHR (95% CI) 0.60 (0.31–1.16) p = .13), statistical significance was not met likely due to the low sample size and higher rate of ambulatory rhythm monitoring in the HD group (61% vs. 39%, p = .025).ConclusionCompared to non‐HD mapping, AAFL ablation with HD mapping is associated with improvements in the ability to define the AAFL circuit, greater procedural success, and a reduction in the number of ED visits and hospitalization for AF/AFL/HF.
Numerical simulation of continuous microwave drying of rice grains
Authors: Li Bin , Feng Shaopeng , He Qiyu , Zhu Yansong , Wu Jiali , Yang Jingfan , Hu Zhigang , Ma Ming 
Published: July 2024

AbstractTo comprehensively understand temperature and moisture changes in a continuous microwave rice grain drying system, this study proposes a simulation strategy that facilitates the continuous movement of rice grains. The study establishes a three‐dimensional model concerning multiple physical fields, including electromagnetism, heat, and mass transfer. It examines the effects of rice grain layer thickness and microwave intensity on the moisture and temperature of rice grains. The results indicate that the drying rate is negatively correlated with material thickness but positively correlated with temperature. The optimal thickness for the rice grain layer is 8 mm. Furthermore, both the microwave drying rate and temperature increase with microwave intensity. These findings contribute to a deeper understanding of the hydrothermal change mechanisms in rice grains during microwave drying.Practical applicationsMicrowave drying, as an emergent drying technology, has garnered widespread attention for its selective heating, efficient drying, energy savings, and environmental protection. Nevertheless, enhancing uniformity during the microwave heating process constitutes an important research topic in scientific research and technological applications. Numerical simulation methods can visually analyze electric field distribution, thereby optimizing microwave heating uniformity and improving drying effects. This article aims to accurately predict the continuous microwave drying time of paddy and maximize energy usage by optimizing drying thickness and microwave power parameters establishing a mathematical model for the process. The study not only provides a solid theoretical basis for microwave dryer design but also scientifically guides the continuous microwave drying of rice and other food crops.
Innovative application of microencapsulated polyphenols in cereal products: Optimization of the formulation of dairy‐ and gluten‐free pastry
Authors: Bińkowska Weronika , Szpicer Arkadiusz , Stelmasiak Adrian , Wojtasik‐Kalinowska Iwona , Półtorak Andrzej 
Published: July 2024

AbstractDuring the last decade, consumers pay much attention to the food they eat. They try to choose functional products that have a beneficial effect on health and well‐being, beyond their typical nutritional function. For this reason, the primary aim of the study was to create a gluten‐free and dairy‐free cereal product with increased polyphenol and fiber content. Microencapsulation technology using freeze‐drying method and trehalose as matrix material was used in order to protect the polyphenols from the degradation during processing. The effect of the content of beta‐glucan concentrate, polyphenol microencapsulation and acai oil on the physicochemical properties of pastry products was studied. Response surface methodology was used to optimize the product formulation. The scope of work included analysis of process efficiency, instrumental analysis of color and texture, analysis of total antioxidant capacity, assessment of the content of polyphenols, flavonoids, and beta‐glucan, volume testing, analysis of the profile of fatty acids and volatile compounds, and assessment of sensory acceptability. Based on the obtained data, a response surface model was developed to determine the optimal recipe for the final product. The predicted data were verified using empirical methods. It was found that the optimal formulation of the product involves incorporating 6.48% polyphenol microcapsules, 7.60% beta‐glucan concentrate and 3.71% acai oil. The final product had higher content of polyphenols and beta‐glucan, as well as higher antioxidant activity compare to conventional product. Moreover, it was characterized by physical characteristics similar to the standard product and high sensory acceptability.Practical applicationsConsumers are currently eager to purchase fortified products with beneficial effects on health and well‐being. The developed functional product with increased polyphenol and beta‐glucan content, high antioxidant activity, is anticipated to garner significant consumer acceptance. The product, with its significant health‐promoting and well‐being enhancing properties, along with characteristics similar to conventional products, is poised to effectively meet consumers' needs and expectations. Additionally, it addresses a market void for bakery items tailored specifically for individuals with gluten intolerance, celiac disease, or cow's milk protein allergy. It provides a safe consumption option for these groups, offering a product similar to conventional items found on shelves that they are unable to consume.
Optimization of encapsulation parameters for sodium alginate capsules: A study on the effect of temperature and gear pump rotation speed on capsule production and quality
Authors: Tashybayeva Marzhan , Kakimov Aitbek , Ibragimov Nadir , Zhumadilova Gulmira , Muratbayev Аlibek , Jumazhanova Madina , Idyryshev Berik , Kapshakbayeva Zarina , Bepeyeva Aigerim 
Published: July 2024

AbstractThis study designed and evaluated an encapsulator unit for producing biocomponent‐containing capsules using sodium alginate. The encapsulator's principle of operation involved maintaining the gel‐forming mixture at a controlled temperature (20–50°C) and utilizing a gear pump to deliver the mixture to a nozzle for capsule formation. Increasing temperature and gear pump rotation speed reduced viscosity, affecting the capsule number, size, and stability. The optimal capsule size and quality were achieved with a sodium alginate concentration of 1%, yielding capsules with rounded shapes, uniform sizes, and soft yet resistant structures. The encapsulation process yielded varying numbers of capsules depending on the rotational speed of the gear pump and the temperature of the gel‐forming mixture. Higher temperatures and rotation speeds generally resulted in increased capsule yields. This research advances encapsulation technology for delivering sensitive biomaterials like probiotics, aiding in process optimization.Practical applicationsThe encapsulator is designed for the production of capsules using structure‐forming compounds and can be used in biotechnology, chemical, food and other industries. The encapsulator allows for the production of capsules with precise size and shell thickness, ensuring high quality.
Quantifying superimposed protein flow dynamics in live cells using spatial filtering and spatiotemporal image correlation spectroscopy
Authors: Migueles‐Ramírez Rodrigo A. , Cambi Alessandra , Hayer Arnold , Wiseman Paul W. , van den Dries Koen 
Published: July 2024

AbstractFlow or collective movement is a frequently observed phenomenon for many cellular components including the cytoskeletal proteins actin and myosin. To study protein flow in living cells, we and others have previously used spatiotemporal image correlation spectroscopy (STICS) analysis on fluorescence microscopy image time series. Yet, in cells, multiple protein flows often occur simultaneously on different scales resulting in superimposed fluorescence intensity fluctuations that are challenging to separate using STICS. Here, we exploited the characteristic that distinct protein flows often occur at different spatial scales present in the image series to disentangle superimposed protein flow dynamics. We employed a newly developed and an established spatial filtering algorithm to alternatively accentuate or attenuate local image intensity heterogeneity across different spatial scales. Subsequently, we analysed the spatially filtered time series with STICS, allowing the quantification of two distinct superimposed flows within the image time series. As a proof of principle of our analysis approach, we used simulated fluorescence intensity fluctuations as well as time series of nonmuscle myosin II in endothelial cells and actin‐based podosomes in dendritic cells and revealed simultaneously occurring contiguous and noncontiguous flow dynamics in each of these systems. Altogether, this work extends the application of STICS for the quantification of multiple protein flow dynamics in complex biological systems including the actomyosin cytoskeleton.