bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resiliensi akademik pada mahasiswa tingkat akhir : Bagaimana peranan optimisme dan efikasi diri?
Authors: Putri Dila Meilita Karunia , Santi Dyan Evita , Kusumandari Rahma 
Published: August 2024

Abstract
This study aims to determine the relationship between optimism and self-efficacy with academic resilience in final year students. The subjects of this study were 132 psychology students at the University of 17 August 1945 Surabaya who were preparing their thesis. Measuring tools used are optimism scale, self-efficacy scale and academic resilience scale. The analysis of this study uses multiple regression analysis. The results of this study indicate 1) There is a positive relationship between optimism and academic resilience in final year students. This means that the higher the optimism, the higher the academic resilience; 2) There is a positive relationship between self-efficacy and academic resilience in final year students. This means that the higher the self-efficacy, the higher the academic resilience; 3) There is a relationship between optimism and self-efficacy with academic resilience. Therefore, all hypotheses in this study are accepted. This research is expected to contribute to describing the attitude of optimism and self-efficacy with academic resilience in final year students in preparing their thesis.
Keywords: Optimism, Self-Efficacy, Academic Resilience
Abstrak
Penelitian ini bertujuan untuk mengetahui hubungan antara optimisme dan efikasi diri dengan resiliensi akademik pada mahasiswa tingkat akhir. Subjek penelitian ini sebanyak 132 mahasiswa Psikologi Universitas 17 Agustus 1945 Surabaya yang sedang menyusun skripsi. Alat ukur yang digunakan yaitu skala optimisme, skala efikasi diri dan skala resiliensi akademik. Analisis penelitian ini menggunakan analisis regresi berganda. Hasil dari penelitian ini menunjukkan 1) Adanya hubungan yang positif antara optimisme dengan resiliensi akademik pada mahasiswa tingkat akhir. Artinya semakin tinggi optimisme maka akan semakin tinggi pula resiliensi akademik ; 2) Adanya hubungan yang positif antara efikasi diri dengan resiliensi akademik pada mahasiswa tingkat akhir. Artinya semakin tinggi efikasi diri maka semakin tinggi resiliensi akademik ; 3) Adanya hubungan hubungan antara optimisme dan efikasi diri dengan resiliensi akademik. Oleh karena itu, semua hipotesis pada penelitian ini diterima. Penelitian ini diharapkan memberi kontribusi dalam menggambarkan sikap optimisme dan efikasi diri dengan resiliensi akademik pada mahasiswa tingkat akhir dalam penyusunan skripsi.
Kata kunci: Optimisme, Efikasi Diri, Resiliensi Akademik
Application of Ensemble Tree Algorithm for Installment Payment Arrears Prediction at Makmur Bersama Credit Union
Authors: Khumaidi Ali , Darmawan Risanto , Reztrianti Diajeng 
Published: August 2024

<span lang="EN-US">One of the widely used machine learning techniques is the ensemble tree method, which is a combination of several classification trees where the final decision is based on the combined predictions of each tree. This approach produces better accuracy than a single classification tree. Two common methods used in the ensemble tree technique are boosting and bagging. This research will predict the status of installment payments at CU Makmur Bersama Credit Union. The method used is the bagging tree method, namely random forest and boosting, namely AdaBoost. To get optimal results, hyperparameter tuning is also carried out. The results showed that the boosting and bagging ensemble tree methods were able to handle the classification of cooperative loan installment payment status better than the distance approach, namely kNN (single classification). The performance of the boosting ensemble tree with the AdaBoost model has an accuracy of 72.89% better than the bagging ensemble tree with the random forest model whose accuracy is 72.08%.</span>
Íleo meconial y falsos negativos del resultado de tripsina inmunorreactiva en una niña portadora de fibrosis quística
Authors: Martínez Andrea , Maurente Lucía , Rebellato Cecilia , Pinchak Catalina , García Loreley 
Published: August 2024

Introducción: la fibrosis quística (FQ) es una enfermedad genética, multisistémica, caracterizada por la disfunción de las glándulas de secreción exocrina secundaria a la mutación de una proteína transmembrana que actúa como canal de cloro. La inclusión de su búsqueda en el Sistema Nacional de Pesquisa Neonatal (SNPN) determinó un gran impacto sobre la morbimortalidad de esta enfermedad, permitiendo un diagnóstico y tratamiento precoz. El íleo meconial (IM) es la manifestación más precoz de la enfermedad, ocurriendo en un 10% a 18% de los pacientes.
Objetivo: describir una forma de presentación precoz de FQ con resultado de pesquisa neonatal normal.
Caso clínico: 18 meses. Sexo femenino; 33 semanas de edad gestacional. Retraso en la expulsión del meconio. Al tercer día de vida íleo meconial con oclusión intestinal, vólvulo de intestino medio y necrosis intestinal. Se realiza resección quirúrgica. Tripsina inmunorreactiva (TIR) normal a los 7 y 23 días de vida. No se solicita proteína asociada a la pancreatitis (PAP).
Desnutrición crónica, bronquiolitis grave a los 3 meses, neumonías virales a los 7 y 11 meses. Ingreso con diagnóstico de neumonía aguda comunitaria con insuficiencia respiratoria. Test del sudor alterado en dos oportunidades. Elastasa pancreática insuficiente. Se aísla Staphylococcus aureus y Pseudomonas aeruginosa en exudado nasal y de secreciones respiratorias. Estudio genético: mutación Delta F508. Con diagnóstico de FQ se inició abordaje multidisciplinario, tratamiento y derivación al centro especializado.
Conclusiones: la existencia de IM puede dar falsos negativos en el valor de la TIR, siendo necesaria la dosificación de la PAP. El pronóstico de estos pacientes va a depender de un diagnóstico precoz y el manejo terapéutico oportuno en centros especializados.
Inducción de tolerancia inmune en menores de 18 años con hemofilia A
Authors: Lemos Felipe , Casuriaga Ana Laura , Petraccia Carlos , Fraga Laura , Giachetto Gustavo 
Published: August 2024

Introducción: el desarrollo de inhibidores contra el factor VIII (FVIII) es la complicación más seria del tratamiento en la hemofilia A. La inducción de tolerancia inmune (ITI) permite utilizar nuevamente el concentrado de FVIII para profilaxis o tratamiento.
Objetivos: describir la experiencia con la ITI en menores de 18 años con hemofilia A severa (HAS) en un prestador integral de salud pública.
Material y métodos: estudio descriptivo, retrospectivo, de menores de 18 años con HAS, concentraciones de inhibidores de FVIII ≥ a 5 UB, a quienes se les realizó ITI y seguimiento completo entre 2009 y 2020. Para la ITI se utilizó concentrado de FVIII derivado plasmático. El beneficio se expresa como la tasa de éxito definido por la negativización del inhibidor.
Resultados: se incluyeron seis pacientes. Edad promedio al diagnóstico de inhibidor 2,96 años, luego de 24,4 días de exposición (DDE) a concentrados de FVIII. Media de inicio de ITI 3,76 niños y el tiempo de latencia del diagnóstico de inhibidor y el inicio de la ITI fue de 10,33 meses. El pico máximo del título pre-ITI fue en promedio de 114,7 UB. Cuatro pacientes iniciaron el régimen de ITI con títulos de inhibidor menor a 10 UB. El título del inhibidor se negativizó en 8,2 meses y el porcentaje de recuperación in vivo >65% se logró con una media de 15,7 meses. La ITI fue exitosa en 83% de los casos.
Conclusiones: en niños con hemofilia A e inhibidores de alto título, la ITI tiene un elevado éxito, tal como ocurrió en esta serie. Dado que el tiempo de respuesta es variable, la ITI debe ser individualizada.
Spectrum of diseases and injuries presentation among patients visiting Emergency Department at Janaki Medical College Teaching Hospital
Authors: Hari Narayan Purbey  , Dharma Datta Subedi  , Ram Narayan Mandal  , Renu Sah  
Published: August 2024

Background & Objectives: The Global Burden of Disease study is a systemic effort to quantify the comparative magnitude of the health loss due to diseases, injuries and risk factors by age, sex and geographies in specific point of time. Five out of ten causes of disease burden in 2017 in Nepal are Non-Communicable Disease (NCDs), ischemic heart disease (IHD), Chronic Obstructive Pulmonary Disease (COPD), Lower Respiratory Tract Infection (LRTI) and Tuberculosis (TB). We aimed to find out the demographic, clinical presentation and outcome of Emergency patients at Janaki Medical College Teaching Hospital (JMCTH) Emergency department.
Materials and Methods: A descriptive observational study of patients visiting ED at Janaki Medical College, Ramdaiya, Bhawadi, Dhanusha. Distinctiveness of adult patients who entered the emergency department (ED) in a hospital in Nepal were prospectively recorded in the local emergency registry from 2023-04-15 to 2023-07-18. Post-ED mortality, patient households were followed-up by telephone interviews at 90 days. Patients were diagnosed, treated and admitted in different wards for further evaluation and treatment. Data were collected, analyzed, interpreted, using SPSS version 20.
Results: The majority of patients were male (55.58%) predominantly from Dhanusha (79.4%). Common symptoms included musculoskeletal pain (16.5%), abdominal pain (13.3%), and fever (9.9%). The most common diseases were acute pain abdomen (21.26%) and hypertension (11.06%), Abrasions (35%) and cut injuries (13.59%) were the most frequent injuries. Most of the patients were admitted to the observation ward (52.9%).
Conclusion: Most patients attending emergency department were young males from Dhanusha, primarily of Terai Madheshi and other castes. The results emphasize the necessity of better emergency care services and public health initiatives in Janakpurdham, as well as the critical role of emergency departments which provides services in wide range of acute and chronic diseases.
FATORES QUE INFLUENCIAM A FORMA DAS ÁRVORES DE Tectona grandis L.F
Authors: Sardo Madi João Paulo , Agostini Orso Gabriel , Souza de Oliveira Sebastião Rodrigo do Remédio , McTague John Paul , Libanio Pelissari Allan , Behling Alexandre , Chaves Carvalho Samuel de Pádua , Arce Julio Eduardo 
Published: August 2024

A forma das árvores é influenciada por condições locais, idade e por atividades silviculturais, principalmente em plantios de longa rotação, como no caso de árvores de Tectona grandis. Desta forma, objetivou-se com o presente estudo avaliar a forma das árvores mediante variáveis relacionadas ao povoamento e ao local para verificar a suas influências na forma das árvores de T. grandis. Os dados são provenientes de povoamentos com 19 anos de idade. Utilizou-se do fator de forma artificial (f) para avaliar o comportamento da forma em função das seguintes variáveis: índice de espaçamento relativo, diâmetro médio quadrático, altura dominante e idade. Foi utilizado o algoritmo de Nelder-Mead em conjunto com a análise discriminante para avaliar os grupos formados. Por meio da análise, verificou-se que o maior valor dos coeficientes canônicos das funções foi relacionado ao índice de espaçamento relativo. Ao verificar a influência do desbaste, antes e após a sua aplicação, para as diferentes classes de f, foi observado maior ocorrência de árvores em plantios após a sua aplicação, presentes na classe I (< 0,45) de f. O índice de espaçamento relativo apresentou maior influência na estratificação da variável f, o que coincidiu em árvores em áreas sob influência de desbaste.
Palavras-chave: desbaste; análise discriminante; Nelder-Mead; teca.

Factors influencing the form of Tectona grandis L.F. trees

ABSTRACT: The form of trees is influenced by several factors, including local conditions, age, and silvicultural activities. This is particularly evident in long-rotation plantations, as exemplified by the case of Tectona grandis trees. Therefore, this study aimed to evaluate tree form using variables related to the stand and site to verify their influence on the form of T. grandis trees. The data comes from 19-year-old stands. The artificial form factor (f) was used to evaluate the behavior of the form as a function of the following variables: relative spacing index, quadratic mean diameter, dominant height and age. The Nelder-Mead algorithm was used with discriminant analysis to evaluate the groups formed. The analysis indicated that the highest value of the canonical function coefficients was related to the relative spacing index. When verifying the influence of thinning, before and after its application, for the different classes of f, a greater occurrence of trees in plantations after its application was observed in class I (< 0.45) of f. The relative spacing index showed a greater influence on the stratification of the variable f, which coincided with trees in areas under the influence of thinning.
Keywords: thinning; discriminant analysis; Nelder-Mead; teak.
KRITERIA ORANG CERDAS MENURUT RASULULLAH. SAW
Authors: Aspar Ali , Sudirmansyah  
Published: August 2024

Penelitian ini bertujuan untuk mendeskripsikan kualitas dan kandungan hadits tentang kriteria orang yang cerdas menurut Rasulullah. saw. Dengan cara meneliti sanad, matan dan rawi hadits tersebut secara parsial. Setelah disajikan dan dianalisa data-data yang berhubungan dengan kethiqahan para periwayat yang ada dalam sanad hadits yang diteliti, dan data-data persambungan sanadnya serta matan riwayat Sufyan Bin Waqi’ yang ditakhrij oleh at-Tirmidzi, maka dapat disimpulkan sebagai berikut: Semua periwayat yang ada dalam sanad berjumlah 9 orang, 5 orang periwayat berkulaitas Thiqah (terpercaya), 3 orang periwayat berkualitas dhoif (lemah) dan 1 orang tidak ada komentar dari para ulama hadits. Semua periwayat bertemu dengan periwayat lainnya yang berstatus sebagai gurunya, dengan demikian sanadnya muttasil (bersambung). Matan hadits tersebut ternyata tidak ada shadh (cacat/tercela), artinya tidak bertentangan dengan dalil naqli mapun dalil aqli, dengan demikian hadits Riwayat Tirmidzi nomor hadits 2383 tentang orang yang cerdas menurut para ulama ahli hadits dinyatakan kualitasnya hasan. Adapun metode yang digunakan dalam penelitian hadits ini adalah metode kualitatif dengan pendekatan studi pustaka. Penelitian ini dilaksanakan dengan menghimpun berbagai sumber kepustakaan berupa kitab-kitab hadits yakni: Shahih Bukhari, Sahih Muslim, Sunan Abu Daud, Sunan At-Titmidzi dan Musnad Imam Ahmad. Menurut fokus penelitiannya, penelitian ini akan berfokus kepada dua hal utama yaitu Penelitian Sanad dan Penelitian Matan hadits. Setelah dilakukan pengumpulan data dan analisis hadis secara parsial, penelitian ini berkesimpulan bahwa hadits riwayat Tirmidzi Nomor 2383 tentang kriteria orang cerdas menurut Rasulullah. Saw tergolong ke dalam golongan hadits hasan, baik dari segi sanad maupun matannya.
Clinical trial of arthroscopic debridement combined with functional exercise in the treatment of advanced knee osteoarthritis: A retrospective observational study
Authors: Huang Shiming , Wang Qiang , Chen Daohua , Zhan Peng , Chen Dongfeng 
Published: August 2024

BACKGROUND: Advanced knee osteoarthritis (KOA) impacts both knees, resulting in pain, deformity, and substantial restrictions in joint mobility. OBJECTIVE: This study aims to examine the effectiveness of combining arthroscopic debridement with functional exercise in treating advanced KOA. METHODS: A total of 296 patients diagnosed with advanced KOA were divided into two groups: the observation group (n= 152) received arthroscopic debridement combined with functional exercise, while the control group (n= 144) underwent arthroscopic debridement only. The study compared and observed the outcomes between the two groups. RESULTS: There were no significant differences in knee joint function, inflammation level, and oxidative stress between the two groups before treatment (P> 0.05). Following treatment for six months, the observation group exhibited significantly lower visual analog scale (VAS) score, tissue inhibitors of metalloproteinase-1 (TIMP-1), tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), matrix metalloproteinase-3 (MMP-3), and malondialdehyde (MDA) levels compared to the control group (P< 0.05). Meanwhile, the observation group showed significantly higher levels of Lysholm score, hospital for special surgery (HSS) score, range of motion (ROM) of knee, peak torque (PT) and total work (TW) for knee extension and flexion, superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and glutathione (GSH) compared to the control group (P< 0.05). Besides, the effective treatment rate in the observation group was notably higher than that in the control group (80.92% vs. 69.44%, P< 0.05). CONCLUSION: The combination of arthroscopic debridement with functional exercise is an effective treatment for advanced KOA. This approach not only enhances the function and strength of knee joint and reduces inflammatory response but also boosts the body’s antioxidant capacity. The treatment exhibits encouraging outcomes and warrants broad implementation.
The relationship between smartphone usage position, pain, smartphone addiction, and hand function
Authors: Depreli Ozde , Angin Ender 
Published: August 2024

BACKGROUND: The hand is the most frequently used part of the body during daily life activities. Any musculoskeletal problem that may occur in the hand can lead to loss of function. OBJECTIVE: This study examined the relationship between the wrist and elbow position adapted during smartphone use, pain and discomfort, smartphone addiction, and hand function. METHODS: Pain and discomfort were evaluated with the visual analog scale, wrist and elbow angle during phone use were evaluated with a universal goniometer, smartphone addiction was evaluated with the Smartphone Addiction Scale-Short Version, and functional status of the hand was evaluated with the Michigan Hand Outcomes Questionnaire. RESULTS: A total of 120 university students (female: n= 60), with an average age of 22.71 ± 2.7 years, were included in this cross-sectional study. A relationship was found between the angle of the wrist and elbow during smartphone use and pain/discomfort (r= 0.692, p= 0.001), smartphone addiction (r= 0.575, p= 0.001), and hand function parameters (r= 0.20–0.55, p⩽ 0.05). CONCLUSION: Due to the increased use of smartphones in today’s environment, a preventive program should be developed in which texting for extended periods is avoided, along with frequent breaks to rest the hands, and stretching exercises for the upper extremities during rest.
Glutaminase 1 plays critical roles in myelodysplastic syndrome and acute myeloid leukemia cells
Authors: Okabe* Seiichi , Moriyama Mitsuru , Arai Yuya , Gotoh Akihiko 
Published: August 2024

BACKGROUND: Myelodysplastic syndrome (MDS) features bone marrow failure and a heightened risk of evolving into acute myeloid leukemia (AML), increasing with age and reducing overall survival. Given the unfavorable outcomes of MDS, alternative treatments are necessary. Glutamine, the most abundant amino acid in the blood, is metabolized first by the enzyme glutaminase (GLS). OBJECTIVES: To investigate whether GLS is involved in the progression of MDS. The efficacy of GLS inhibitors (CB839 or IPN60090) and BCL2 inhibitor venetoclax was also examined. METHODS: We employed GLS inhibitors (CB839, IPN60090) and the BCL2 inhibitor venetoclax, prepared as detailed. MDS and AML cell lines were cultured under standard and modified (hypoxic, glutamine-free) conditions. Viability, proliferation, and caspase activity were assessed with commercial kits. RT-PCR quantified gene expression post-shRNA transfection. Mitochondrial potential, ATP levels, proteasome activity, and metabolic functions were evaluated using specific assays. Statistical analyses (t-tests, ANOVA) validated the findings. RESULTS: The glutamine-free medium inhibited the growth of MDS cells. GLS1 expression was higher in AML cells than in normal control samples (GSE15061), whereas GLS2 expression was not. Treatment of MDS and AML cells for 72 h was inhibited in a dose-dependent manner by GLS inhibitors. Co-treatment with the B-cell lymphoma 2 (BCL2) inhibitor venetoclax and GLS inhibitors increased potency. Cells transfected with GLS1 short hairpin RNA showed suppressed proliferation under hypoxic conditions and increased sensitivity to venetoclax. CONCLUSIONS: Targeting glutaminolysis and BCL2 inhibition enhances the therapeutic efficacy and has been proposed as a novel strategy for treating high-risk MDS and AML.
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma
Authors: Zhong Wang-Jing , Zhang Li-Zhen , Yue Feng , Yuan Lezhong , Zhang Qikeng , Li Xuesong , Lin Li 
Published: August 2024

BACKGROUND: WEE1 is a critical kinase in the DNA damage response pathway and has been shown to be effective in treating serous uterine cancer. However, its role in gliomas, specifically low-grade glioma (LGG), remains unclear. The impact of DNA methylation on WEE1 expression and its correlation with the immune landscape in gliomas also need further investigation. METHODS: This study used data from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Gene Expression Omnibus (GEO) and utilized various bioinformatics tools to analyze gene expression, survival, gene correlation, immune score, immune infiltration, genomic alterations, tumor mutation burden, microsatellite instability, clinical characteristics of glioma patients, WEE1 DNA methylation, prognostic analysis, single-cell gene expression distribution in glioma tissue samples, and immunotherapy response prediction based on WEE1 expression. RESULTS: WEE1 was upregulated in LGG and glioblastoma (GBM), but it had a more significant prognostic impact in LGG compared to other cancers. High WEE1 expression was associated with poorer prognosis in LGG, particularly when combined with wild-type IDH. The WEE1 inhibitor MK-1775 effectively inhibited the proliferation and migration of LGG cell lines, which were more sensitive to WEE1 inhibition. DNA methylation negatively regulated WEE1, and high DNA hypermethylation of WEE1 was associated with better prognosis in LGG than in GBM. Combining WEE1 inhibition and DNA methyltransferase inhibition showed a synergistic effect. Additionally, downregulation of WEE1 had favorable predictive value in immunotherapy response. Co-expression network analysis identified key genes involved in WEE1-mediated regulation of immune landscape, differentiation, and metastasis in LGG. CONCLUSION: Our study shows that WEE1 is a promising indicator for targeted therapy and prognosis evaluation. Notably, significant differences were observed in the role of WEE1 between LGG and GBM. Further investigation into WEE1 inhibition, either in combination with DNA methyltransferase inhibition or immunotherapy, is warranted in the context of LGG.