bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypophosphatemia during continuous veno-venous hemofiltration is associated with mortality in critically ill patients with acute kidney injury
Authors: Yang Yi , Zhang Ping , Cui Yu , Lang Xia Bing , Yuan Jing , Jiang Hua , Lei Wen Hua , Lv Rong , Zhu Yi Ling , Lai En Yin , Chen Jiang Hua 
Published: September 2013

Abstract
Introduction
The primary aim of this study was to determine whether hypophosphatemia during continuous veno-venous hemofiltration (CVVH) is associated with the global outcome of critically ill patients with acute kidney injury (AKI).

Methods
760 patients diagnosed with AKI and had received CVVH therapy were retrospectively recruited. Death during the 28-day period and survival at 28 days after initiation of CVVH were used as endpoints. Demographic and clinical data including serum phosphorus levels were recorded along with clinical outcome. Hypophosphatemia was defined according to the colorimetric method as serum phosphorus levels < 0.81 mmol/L (2.5 mg/dL), and severe hypophosphatemia was defined as serum phosphorus levels < 0.32 mmol/L (1 mg/dL). The ratio of CVVH therapy days with hypophosphatemia over total CVVH therapy days was calculated to reflect the persistence of hypophosphatemia.

Results
The Cox proportional hazard survival model analysis indicated that the incidence of hypophosphatemia or even severe hypophosphatemia was not associated with 28-day mortality independently (p = 0.700). Further analysis with the sub-cohort of patients who had developed hypophosphatemia during the CVVH therapy period indicated that the mean ratio of CVVH therapy days with hypophosphatemia over total CVVH therapy days was 0.58, and the ratio independently associated with the global outcome. Compared with the patients with low ratio (< 0.58), those with high ratio (≥ 0.58) conferred a 1.451-fold increase in 28-day mortality rate (95% CI 1.103–1.910, p = 0.008).

Conclusions
Hypophosphatemia during CVVH associated with the global clinical outcome of critically ill patients with AKI. The ratio of CVVH therapy days with hypophosphatemia over total CVVH therapy days was independently associated with the 28-day mortality, and high ratio conferred higher mortality rate.
Intraspecific variation of recombination rate in maize
Authors: Bauer Eva , Falque Matthieu , Walter Hildrun , Bauland Cyril , Camisan Christian , Campo Laura , Meyer Nina , Ranc Nicolas , Rincent Renaud , Schipprack Wolfgang , Altmann Thomas , Flament Pascal , Melchinger Albrecht E , Menz Monica , Moreno-González Jesús , Ouzunova Milena , Revilla Pedro , Charcosset Alain , Martin Olivier C , Schön Chris-Carolin 
Published: September 2013

Abstract
Background
In sexually reproducing organisms, meiotic crossovers ensure the proper segregation of chromosomes and contribute to genetic diversity by shuffling allelic combinations. Such genetic reassortment is exploited in breeding to combine favorable alleles, and in genetic research to identify genetic factors underlying traits of interest via linkage or association-based approaches. Crossover numbers and distributions along chromosomes vary between species, but little is known about their intraspecies variation.

Results
Here, we report on the variation of recombination rates between 22 European maize inbred lines that belong to the Dent and Flint gene pools. We genotype 23 doubled-haploid populations derived from crosses between these lines with a 50 k-SNP array and construct high-density genetic maps, showing good correspondence with the maize B73 genome sequence assembly. By aligning each genetic map to the B73 sequence, we obtain the recombination rates along chromosomes specific to each population. We identify significant differences in recombination rates at the genome-wide, chromosome, and intrachromosomal levels between populations, as well as significant variation for genome-wide recombination rates among maize lines. Crossover interference analysis using a two-pathway modeling framework reveals a negative association between recombination rate and interference strength.

Conclusions
To our knowledge, the present work provides the most comprehensive study on intraspecific variation of recombination rates and crossover interference strength in eukaryotes. Differences found in recombination rates will allow for selection of high or low recombining lines in crossing programs. Our methodology should pave the way for precise identification of genes controlling recombination rates in maize and other organisms.
Binary Flutter as an Oscillating Windmill — Scaling & Linear Analysis
Authors: Farthing S. P. 
Published: September 2013

Alternating pitch and heave of a foil can tap light wind or slow free water flow, as the design flow speed for an oscillating blade in any fluid is shown to be limited by its material's ratio of endurance stress to density. The free amplitude of flutter instability is inherently suited to reciprocating a pump whose stroke needs to vary to efficiently capture the changeable wind. Whereas the useful pumping work of multiblade rotary windpumps with their fixed stroke is only 10% of the ideal annual wind energy capture. Stability algebra of a foil free in pitch and elastic in heave is analytically solved for the first time to prove the stability contours of all Theodorsen frequencies radiate from the same super node of total imbalance and pitch inertia the same as for a virtual mass confined to the 3/4 chord point. The flutter frequency only involves these totals and the trail of the center of pressure behind the pitch axis. Oscillation is damped in the low ratios of total to virtual typical of hydrofoils in water but heavier- than-air wings can be unstable. High intrinsic pitch inertia ratio and trail decrease the tailheavy imbalance ratio needed to force pitch by heave. Perturbing the equations for heave varying as semi-rotary roll, an unswept wing of low enough dynamic imbalance ratio can start to flutter in light wind but stop and feather in storms. The dynamic imbalance can be reduced at large scale and low design windspeed where the gravity effect of static imbalance more safely forces pitch. Between starting and stopping, the amplitude ratio of pitch to roll drops, containing the rise with windspeed of the bending moment amplitude.
The effect of surgical approach on the histology of the femoral head following resurfacing of the hip
Authors: Amarasekera H. W. , Campbell P. C. , Parsons N. , Achten J. , Masters J. , Griffin D. R. , Costa M. L. 
Published: September 2013

ObjectivesWe aimed to determine the effect of surgical approach on the histology of the femoral head following resurfacing of the hip.MethodsWe performed a histological assessment of the bone under the femoral component taken from retrieval specimens of patients having revision surgery following resurfacing of the hip. We compared the number of empty lacunae in specimens from patients who had originally had a posterior surgical approach with the number in patients having alternative surgical approaches.ResultsWe found a statistically significant increase in the percentage of empty lacunae in retrieval specimens from patients who had the posterior approach compared with other surgical approaches (p < 0.001).ConclusionsThis indicates that the vascular compromise that occurs during the posterior surgical approach does have long-term effects on the bone of the femoral head, even if it does not cause overt avascular necrosis. Cite this article: Bone Joint Res 2013;2:200–5.
Adsorption of radiocesium from aqueous solution using chemically modified pine cone powder
Authors: Naidoo Eliazer Bobby , Pholosi Agnes , Ofomaja Augustine Enakpodia 
Published: September 2013

Abstract
In this study, toluene&ndash;ethanol mixtures were investigated as chemical modifying agents for pine cone powder (PCP) and the optimum modification ratio determined by measuring the improvement in surface properties of the PCP such as Brunauer&ndash;Emmett&ndash;Teller (BET) surface area, bulk density, and surface negative charge. The modified adsorbents were then applied for the removal of cesium ions from aqueous solution. The result revealed that the chemically modified PCP had better surface properties than the raw BET surface area, and X-ray diffraction (XRD) spectra revealed that the surface area improved and cellulose crystallinity reduced. Cesium adsorption by the chemically modified PCP was much higher than for the raw PCP. Desorption studies were also performed to evaluate the mechanism of adsorption.
An Unconfined Swelling Test for Clayey Soils That Incorporates Digital Image Correlation
Authors: Lim B. F. , Siemens G. A. 
Published: September 2013

Abstract
A new laboratory test apparatus and methodology have been developed for characterizing the swelling potential of expansive soil under free stress conditions. Soil specimens are given access to water under true free swell conditions, and the maximum swelling potential is determined experimentally. Real-time deformation measurements and interpretation are obtained through digital image correlation using GeoPIV. The capabilities of the new test are illustrated using a remolded natural swelling soil. Both primary and secondary swelling behavior were observed during testing. The effect of the aspect ratio was assessed, and it was found that smaller specimens achieved equivalent swelling strains with significantly shorter test durations. The non-contact deformation results agree with the end-of-test hand measurements. The non-contact method also provides additional valuable information regarding the time-dependent swell behavior and evaluation of the end-of-test criterion. The results are interpreted using the Swell Equilibrium Limit, which is a unifying framework for the analysis and prediction of swelling soil deformations under defined initial and boundary conditions.
A New Method to Simulate Stress–Strain Relations from Multiple-Step Loading Triaxial Compression Test Results
Authors: Taheri A. , Tatsuoka F. 
Published: September 2013

Abstract
Multiple-step loading (ML) on a single specimen can be used to determine the peak compressive strengths at different confining pressures (σ′hS) of cement-mixed gravel (CMG) very similar to those obtained by single-step loading (SL) drained triaxial compression (TC) tests. However, only the unload/reload stress–strain relations at different σ′hS (except for the primary loading one at the first step) can be obtained from a ML test and the reloading relations become softer with an increase in the negative irreversible axial strain increment that has taken place during respective immediately preceding unloading regimes. This effect gradually decreased during reloading while it totally disappeared once large-scale yielding started. An empirical equation was developed to derive undamaged reloading stress–strain curves (URCs) by removing the damage effects from ML TC test measured reloading curves (MRCs). A new simple method was developed in the framework of proportional rule to simulate primary loading curves (PLCs) at different σ′hS from the MRCs from a given ML TC test using a correlation factor. A practical procedure for simulation of PLCs in a ML test were established and applied to generate PLCs in a ML test increasing σ′h and a ML test decreasing σ′h. The method was validated by comparing the PLCs simulated from the results of a pair of ML tests increasing and decreasing σ′h with those measured in a set of SL TC tests at different σ′hS.
Evolution After Whole-Genome Duplication: A Network Perspective
Authors: Zhu Yun , Lin Zhenguo , Nakhleh Luay 
Published: September 2013

AbstractGene duplication plays an important role in the evolution of genomes and interactomes. Elucidating how evolution after gene duplication interplays at the sequence and network level is of great interest. In this work, we analyze a data set of gene pairs that arose through whole-genome duplication (WGD) in yeast. All these pairs have the same duplication time, making them ideal for evolutionary investigation. We investigated the interplay between evolution after WGD at the sequence and network levels and correlated these two levels of divergence with gene expression and fitness data. We find that molecular interactions involving WGD genes evolve at rates that are three orders of magnitude slower than the rates of evolution of the corresponding sequences. Furthermore, we find that divergence of WGD pairs correlates strongly with gene expression and fitness data. Because of the role of gene duplication in determining redundancy in biological systems and particularly at the network level, we investigated the role of interaction networks in elucidating the evolutionary fate of duplicated genes. We find that gene neighborhoods in interaction networks provide a mechanism for inferring these fates, and we developed an algorithm for achieving this task. Further epistasis analysis of WGD pairs categorized by their inferred evolutionary fates demonstrated the utility of these techniques. Finally, we find that WGD pairs and other pairs of paralogous genes of small-scale duplication origin share similar properties, giving good support for generalizing our results from WGD pairs to evolution after gene duplication in general.
Structure and activity of the geothermal field of Hvalfjörður (Iceland) from brittle tectonic, geothermal and paleostress analysis
Authors: Bergerat Françoise , Sæmundsson Kristjan , Fourel Loïc , Angelier Jacques 
Published: September 2013

AbstractThis paper presents the results of brittle tectonic, palaeostress inversion, and hydrothermal mineralisation studies of the Hvalfjörður low-temperature geothermal field in Southwest Iceland. This geothermal field (including two pronounced thermal anomalies) is located in the highly altered core area of an extinct and deeply eroded Tertiary central volcano. Most of the geothermal water appears to be conducted by vertical extension fractures. Palaeostress analysis indicates a rather complex stress history, with four major trends of extension involving normal and strike-slip faulting modes as well as dyke injection. Analysis of the data on the relative chronology indicates that these four regimes were closely intricate in time and space. The most important regime is a NW-SE, rift-perpendicular extension related to the oceanic rifting in Iceland. This trend partly controls the past (Pliocene-Early Pleistocene) hydrothermal activity in the Hvalfjörður area; however, an E-W rift-oblique extension also occurred with a N-S trending fracture system including normal faults, dykes and veins that show higher levels of hydrothermal mineralisation. Currently, there is strong hot-water convection, producing a thermal anomaly, in this N-S-trending fracture system. Our study highlights the paleostress evolution and the development of fracture systems in Hvalfjörður, including the past geothermal history; nevertheless the most efficient tool in geothermal prospection in such complex area remains the shallow geothermal survey. It has proved successful in many localities in Early Pleistocene to Miocene rocks where no surface indication of geothermal activity exists.
Fracture patterns and their relations to mountain building in a fold-thrust belt: A case study in NW Taiwan
Authors: Chu Hao-Tsu , Lee Jian-Cheng , Bergerat Françoise , Hu Jyr-Ching , Liang Shen-Hsiung , Lu Chia-Yu , Lee Teh-Quei 
Published: September 2013

AbstractThe main purpose of this study is to analyse striated micro-faults and other types of fractures (including tensile and shear joints, and veins), in order to elucidate their relationships with regional folds and thrusts and regional tectonic stress. We take the fold-thrust belt (i.e., the foothills and the Hsuehshan range) in NW Taiwan as a case study, which is a product of the Plio-Pleistocene arc-continent collision. A total of about 760 and 1700 faults and other fractures, respectively, were collected at 41 sites in the field. We have identified four sets of bed-perpendicular joints in the study area. The observation of joints and bedding at each site indicates that most of the penetrative joint sets developed in the earlier tectonic stage of the pre-folding/pre-tilting event, illustrating the fact that the intersection of joint sets lies along the line perpendicular to the bedding plane. We thus interpret these sets as tectonic fractures under deep-seated tectonic stress. We used the regional fold axes as reference to define the four fracture sets. However, we found that complexity in the study area makes this rather tentative. Principal stress axes σ1, σ2, σ3, were calculated by means of inversion of fault slip data at each site. The ratio Φ that defines the shape of stress ellipsoid is generally small, indicating that the value of the maximum principal stress axe σ1 is much larger compared to that of σ2 and σ3, which are approximately equal. The paleostress regime was characterized by a combination of thrust and strike-slip tectonic regimes. Based on their geometric relationships with tilted bedding, we found most of striated micro-faults were strongly related to the regional folding and can be categorized as early-, during, and late-folding stages. We characterized two major directions for the compressive event, oriented N110–120°E and N150–160°E respectively, which provide additional evidence to delineate the debates about paleostress changes in the Taiwan mountain building process.
Late Jurassic-Early Cretaceous faulting in the Southeastern French basin: does it reflect a tectonic reorganization?
Authors: Homberg Catherine , Schnyder Johann , Benzaggagh Mohamed 
Published: September 2013

AbstractWe present new data constraining the Late Jurassic to Early Cretaceous evolution of the Southeastern French basin (SFB). Meso-scale faults with displacement of several decimeters to 1–2 meters were sampled for geometric and kinematic data analysis and the faulted and un-faulted sedimentary units were examined for sedimentologic and bio-stratigraphic purposes. Small-scale faults were also extensively collected to determine the local stress states during this period. Meso-scale normal faults formed during sediment deposition or before its complete lithification attest of a recurrent activity in the Late Jurassic to Early Cretaceous period in an overall extensional context. The fault network cutting the Oxfordian to Aptian sequences included normal faults of various trends, ranging between WSW-ENE and NNW-SSE. We show that the deformation mechanism in the SFB drastically changed in the Jurassic-Cretaceous transition (latermost Tithonian?), with the direction of extension rotating from a WNW-ESE to a NNE-SSW direction. Lateral thickness variation of the sequences, redistribution of sediments, faulting at various scales concur that the Early Cretaceous period marks a tectono-stratigraphic reorganization of the basin. We suggest that it traduces the rifting and later opening of the North Atlantic (main branch and bay of Biscay branch).
Onset and Progression of Diabetic Glomerulosclerosis: A Prospective Study Based on Serial Renal Biopsies
Authors: Takazakura Eisuke , Nakamoto Yasushi , Hayakawa Hiroyuki , Kawai Kohzo , Muramoto Shingo , Yoshida Kohjiro , Shimizu Masahiko , Shinoda Akira , Takeuchi Jugoro 
Published: September 2013

Clinical factors related to the development and progression of renal lesions were studied in twenty-three diabetics by the use of serial renal biopsies or autopsy. The results were as follows:
Most of the juvenile and intermediate type diabetics were poorly controlled, with the glomerular lesion progressing rather rapidly. In contrast, many cases of the adult type were able to be maintained under good control and the renal lesion neither developed nor progressed. Two of the adult type diabetics with poor control showed slowly and slightly progressing renal lesions.
The progression of glomerular lesions was significantly related to the control of blood glucose, type of diabetes, age at onset, type of treatment, and degree of obesity, but not to the duration of diabetes or the length of the follow-up period. There was a significant correlation between the type of diabetes and the control of blood glucose over the years.
Arteriolar lesions developed concurrently with the progression of the glomerular lesion. Retinopathy also had a tendency to develop in proportion to the progress of glomerular lesions although it was not statistically significant.
We have discussed the clinical factors responsible for the progression of diabetic glomerulosclerosis and have suggested that the type of diabetes rather than the degree of control of blood glucose might be more important in determining the development and progression of diabetic glomerulosclerosis. Nevertheless, the possibility remains that successful control of blood glucose may prevent or retard the development of diabetic glomerulosclerosis.
A Difference Between the Inheritance of Classical Juvenile-onset and Maturity-onset Type Diabetes of Young People
Authors: Tattersall Robert B , Fajans Stefan S , Arbor Ann 
Published: September 2013

A difference in the inheritance of diabetes has been shown between the families of twenty-six patients with maturity-onset type diabetes of young people (MODY) and families of thirty-five patients with classical juvenile-onset diabetes (JOD).
In the families of MODY: 1) twenty-two of twenty-six (85 per cent) propositi had a diabetic parent; 2) 46 per cent of families showed direct vertical transmission of diabetes through three generations; 3) of forty-seven tested siblings twenty-five (53 per cent) had latent diabetes; 4) the diabetic phenotype in the families was consistent, most affected individuals having a noninsulin requiring type of disease. These findings are compatible with autosomal dominant inheritance of MODY, although they do not exclude multifactorial inheritance. In contrast, in the families of JOD: 1) only four (11 per cent) of propositi had a diabetic parent; 2) three generation inheritance was found in only two (6 per cent) of JOD families, and 3) of seventyfour tested siblings eight (11 per cent) were diabetic. This difference provides further evidence of genetic heterogeneity in diabetes mellitus and indicates that there is a need for careful definition of the phenotype of diabetes in populations in which the genetics of diabetes is to be analyzed.
Evaluation of the Three-hour Oral Glucose Tolerance Test in Detection of Significant Hyperglycemia and Hypoglycemia in Pregnancy
Authors: Abell D A , Beischer N A 
Published: September 2013

Analysis of 2,000 consecutive patients who had a three-hour 50-gm. oral glucose tolerance test done in the third trimester of pregnancy has shown that the three-hour reading was not necessary for the diagnosis of gestational diabetes.
It was found that hyperglycemia and hypoglycemia (95th and 5th percentiles, respectively, for plasma glucose levels) were significantly associated with an increased risk for perinatal mortality. Furthermore, hyperglycemia was associated with an increased incidence of large-for-dates placentas and hypoglycemia with small-for-dates infants and small-for-dates placentas. These associations with hypoglycemia were seen to be greatest when this occurred at the three-hour level, and it was concluded that the three-hour measurement should be retained until the clinical significance of hypoglycemia in pregnancy is fully determined.