bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetrathiafulvalene‐Based Phenanthroline Ligands: Synthesis, Crystal Structures, and Electronic Properties
Authors: Belhadj Esmah , El‐Ghayoury Abdelkrim , Cauchy Thomas , Allain Magali , Mazari Miloud , Sallé Marc 
Published: April 2014

AbstractThe synthesis and full characterization of three tetrathiafulvalene‐based phenanthroline ligands, namely, N‐(1,10‐phenanthrol‐5‐yl)‐6,7‐(ethylenedithio)tetrathiafulvalene‐2‐carboxamide (1), 2‐[(1,10‐phenanthrol‐5‐yl)aminocarbonylmethylthio]‐3,6,7‐tris(methylsulfanyl)tetrathiafulvalene (2), and 2‐[(1,10‐phenanthrol‐5‐yl)iminomethyl]tetrathiafulvalene (3), are described. The electronic absorption properties and the electrochemical behavior of the three ligands have been studied. The UV/Vis absorption spectra of these compounds have been rationalized by time‐dependent DFT (TD‐DFT) calculations, and the single‐crystal X‐ray structures of 2 and 3 have been determined. The binding properties of these multifunctional systems for various transition metal ions (Ni2+, Zn2+, Cd2+, and Fe2+) have been analyzed in solution by cyclic voltammetry and UV/Vis spectroscopy. The results show that these ligands are suitable candidates for the preparation of electroactive metal complexes and radical cation salts.
Copper‐Catalyzed Intramolecular Oxidative C(sp3)–H Amidation of 2‐Aminoacetophenones: Efficient Synthesis of Indoline‐2,3‐diones
Authors: Huang Jinbo , Mao Tingting , Zhu Qiang 
Published: April 2014

AbstractAn efficient synthesis of diverse indoline‐2,3‐diones from 2‐aminoacetophenones through copper‐catalyzed intramolecular C(sp3)–H amidation is developed. The reaction proceeds in DMSO by using O2 as the sole oxidant to provide the desired products in moderate to good yields.
Arylethynyl‐Substituted Tristriazolotriazines: Synthesis, Optical Properties, and Thermotropic Behavior
Authors: Glang Stefan , Rieth Thorsten , Borchmann Dorothee , Fortunati Ilaria , Signorini Raffaella , Detert Heiner 
Published: April 2014

AbstractThe synthesis of C3‐symmetrical tristriazolotriazines with conjugated arms and lateral alkoxy side chains was performed by a threefold condensation of cyanuric chloride with tetrazoles. Conjugated π segments include phenyl, tolane, and its phenylethynyl‐elongated homologue. Disclike and a dendritic molecule have been obtained, and two compounds with a 3,4,5‐tris(octyloxy) substitution form broad thermotropic mesophases. The linear optical properties, solvatochromism of the fluorescence, acidochromism, and the two‐photon absorption efficiency of selected compounds are reported.
Base‐Catalyzed Domino Michael–Alkylation–Rearrangement Reaction: A Synthetic Route to Functionalized 2,3‐Dihydrofurans
Authors: Zhang Ren‐Zun , Meng Chang‐Yu , Xie Jian‐Wu , Xu Mei‐Lan , Zhu Wei‐Dong 
Published: April 2014

AbstractAn unexpected and efficient domino reaction of N‐sulfonyl‐1‐aza‐1,3‐dienes with 2‐halo‐1,3‐dicarbonyl compounds to synthesize differently substituted 2,3‐dihydrofuran derivatives with excellent regio‐, chemo‐, and stereoselectivity in moderate to good yields was developed. In this transformation, broad substrate scope was demonstrated, and a plausible mechanism for this novel domino reaction was given.
A hidden renewal model for monitoring aquatic systems biosensors
Authors: Azaïs R. , Coudret R. , Durrieu G. 
Published: April 2014

AbstractThis article proposes a method to model signals of oysters’ openings over time using a four‐state renewal process. Two of them are of particular interest and correspond to instants when the animals are open or closed. An estimator of the cumulative jump rate of the renewal process is provided. It relies on observations of the jumps between the four states. Here, these measures are not available, but the observed signal is assumed to take ranges of real values according to this underlying process. A procedure to estimate a probability density function that summarizes the information of the signal is explained. This leads to estimation of the hidden renewal process and of its cumulative jump rate for each oyster. We propose to classify these estimated functions for a group of oysters in order to discriminate these animals according to their health status. Such a diagnosis is essential when using these animals as biosensors for water quality assessment. Copyright © 2014 John Wiley & Sons, Ltd.
Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: A case report
Authors: Adi Ahmad H. , Alturkmani Hani , Spock Todd , Williams Yohannes Patrice , Wargo Susannah , Szabo Eva , Gutkind J. Silvio , Van Waes Carter 
Published: April 2014

AbstractBackgroundParaneoplastic syndromes are systemic or organ‐related functional tumor‐associated changes that arise distant to the tumor.Methods and ResultsWe present a rare case of a 63‐year‐old man with dermatomyositis as a paraneoplastic syndrome developing more than a year before clinical manifestations of tonsillar squamous cell carcinoma (SCC). He subsequently developed stage T1N2bM0 IVA tonsillar SCC. He was treated on a research protocol with 3 weeks of neoadjuvant rapamycin therapy before right transoral lateral pharyngectomy and modified radical neck dissection with preservation of CN XI. His symptoms of dermatomyositis subsequently improved and he was weaned off immunosuppressive therapy.ConclusionTo our knowledge, this is the first report of dermatomyositis as a paraneoplastic syndrome of tonsillar SCC in North America. We suggest that clinicians should monitor for signs of persistent or recurrent dermatomyositis symptoms as this may herald development or a return of the underlying malignancy. © 2014 Wiley Periodicals, Inc. Head Neck 37: E1–E3, 2015
Effect of different irrigation protocols on the radicular dentin interface and bond strength with a metacrylate‐based endodontic sealer
Authors: Gonçalves Lisandro , Silva‐Sousa Yara Teresinha Correa , Raucci Neto Walter , Teixeira Cleonice Silveira , Sousa‐Neto Manoel Damião , Alfredo Edson 
Published: April 2014

ABSTRACTThis study assessed the influence of different endodontic chemical substances on the adhesion of the Epiphany SE/Resilon system (with and without resinous solvent) to radicular dentin walls, using the push‐out test and scanning electron microscopy (SEM). Forty‐eight root canals of human canines were prepared biomechanically with ProTaper rotary files (crown‐down technique) and the radicular dentin was treated with either 17% EDTA, 2% chlorhexidine gel (CHX) or 2.5% NaOCl (control). The root canals were filled with Resilon cones and Epiphany SE sealer with and without resinous solvent. Six groups of eight canals each had their roots sectioned transversally to obtain 1‐mm thick slices. Data were subjected to statistical analysis by ANOVA and Tukey's tests. The specimens treated with 17% EDTA (1.59 ± 0.91) presented higher bond strength (P < 0.05) than those treated with 2.5% NaOCl (0.93 ± 0.27) and 2% CHX (0.92 ± 0.22). Significantly higher bond strength (P < 0.05) was observed when the Epiphany SE was prepared with (1.37 ± 0.78) than without (0.92 ± 0.33) solvent. Adhesive failures were predominant in all groups. SEM analysis showed greater homogeneity of the filling mass when the solvent was added to the sealer. Treatment of root canal walls with 17% EDTA, and addition of a resinous solvent to Epiphany SE produced the highest adhesion to radicular dentin. Microsc. Res. Tech. 77:446–452, 2014. © 2014 Wiley Periodicals, Inc.
Investigating the limitations of single breath‐hold renal artery blood flow measurements using spiral phase contrast MR with R‐R interval averaging
Authors: Steeden Jennifer A. , Muthurangu Vivek 
Published: April 2014

Purpose1) To validate an R‐R interval averaged golden angle spiral phase contrast magnetic resonance (RAGS PCMR) sequence against conventional cine PCMR for assessment of renal blood flow (RBF) in normal volunteers; and 2) To investigate the effects of motion and heart rate on the accuracy of flow measurements using an in silico simulation.Materials and MethodsIn 20 healthy volunteers RAGS (∼6 sec breath‐hold) and respiratory‐navigated cine (∼5 min) PCMR were performed in both renal arteries to assess RBF. A simulation of RAGS PCMR was used to assess the effect of heart rate (30–105 bpm), vessel expandability (0–150%) and translational motion (x1.0–4.0) on the accuracy of RBF measurements.ResultsThere was good agreement between RAGS and cine PCMR in the volunteer study (bias: 0.01 L/min, limits of agreement: −0.04 to +0.06 L/min, P = 0.0001). The simulation demonstrated a positive linear relationship between heart rate and error (r = 0.9894, P < 0.0001), a negative linear relationship between vessel expansion and error (r = −0.9484, P < 0.0001), and a nonlinear, heart rate‐dependent relationship between vessel translation and error.ConclusionWe have demonstrated that RAGS PCMR accurately measures RBF in vivo. However, the simulation reveals limitations in this technique at extreme heart rates (<40 bpm, >100 bpm), or when there is significant motion (vessel expandability: >80%, vessel translation: >x2.2). J. Magn. Reson. Imaging 2015;41:1143–1149. © 2014 Wiley Periodicals, Inc.
Application of a magnetic molecularly imprinted polymer for the selective extraction and trace detection of lamotrigine in urine and plasma samples
Authors: Behbahani Mohammad , Bagheri Saman , Amini Mostafa M. , Sadeghi Abandansari Hamid , Reza Moazami Hamid , Bagheri Akbar 
Published: April 2014

Magnetic molecularly imprinted polymers have been synthesized for the selective preconcentration and trace determination of lamotrigine (LTG) in urine and plasma samples. The magnetic nanoparticles were modified by tetraethyl orthosilicate and 3‐methacryloxypropyl trimethoxysilane before imprinting. The magnetic molecularly imprinted polymers were prepared via surface molecular imprinting technique, using Fe3O4 as a magnetic component, LTG as template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross‐linker, and 2,2′‐azobisisobutyronitrile as a radical initiator in methanol/acetonitrile (50:50, v/v) as the porogen. The obtained sorbent was characterized using scanning electron microscopy, Fourier‐transform infrared spectroscopy, X‐ray diffraction, and thermal analysis. Separation of the sorbent from the sample solution was simply achieved by applying an external magnetic field. Determination of the extracted drug was performed by high‐performance liquid chromatography with UV detection. Under the optimum extraction conditions, the method detection limits were 0.7 μg/L (based on S/N of 3) for urine samples and 0.5 μg/L for plasma samples. A linear dynamic range of 1–1000 μg/L was obtained for LTF in plasma and urine samples. Finally, the applicability of the proposed method was evaluated by extraction and determination of LTG in urine and plasma samples.
Optical In‐Process Monitoring of Direct Metal Laser Sintering (DMLS)
Authors: Grünberger Thomas , Domröse Robert 
Published: April 2014

AbstractAdditive Manufacturing (AM) is a revolutionary technology enabling the users to design and manufacture products in a completely new way. As the AM technology is proceeding from rapid prototyping to rapid manufacturing, industries ranging from aerospace and medical (Fig. 1) to energy and automotive require detailed documentation of the process. The market demands automated in‐process quality inspection. The goal is to get a better understanding of the process and assure repetitive high‐end part quality. Plasmo, a worldwide leading engineering partner for quality inspection systems in the field of laser and joining technologies cooperates with EOS, the technology and market leader for the DMLS technology, and with selected industrial partners to develop a diode based in‐process monitoring system.
Fiber Lasers
Authors: Hartinger Klaus , Holzwarth Ronald 
Published: April 2014

AbstractFiber lasers in general are receiving increased attention for industrial applications and have captured their share next to gas and solid‐state lasers. As a company, we focus on the research of femtosecond fiber technology and the development of laser products which rely on quality, reliability, cost efficiency and versatility. Our customers apply our femtosecond fiber lasers for purposes varying from high precision spectroscopy, to THz generation for quality inspection, to micro‐material processing. Here we will focus on femtosecond fiber lasers and some of the breakthrough developments and progress they have allowed in science and industry.
The Additive Manufacture of Patient‐tailored Finger Implants
Authors: Merkt Simon , Kleyer Arnd , Hueber Axel J. 
Published: April 2014

AbstractStandard finger implants, manufactured by conventional techniques (e.g. machining), as they are used today for patients suffering from inflammatoryrheumatic diseases such as rheumatoid arthritis (RA) or degenerative diseases like osteoarthritis, are lacking of individuality and long‐term stability. In this study here, a way to generate patient tailored finger implants based on XtremeCT technique is described. First finger implants are manufactured by Selective Laser Melting (SLM) and illustrate the feasibility of manufacturing patient tailored implants with additional functionalities. A technical abstraction of the original 3D‐CAD file lead to major functional improvements by adjusting the stiffness of patient tailored implants to imitate bone. This results in less stress shielding and a better long‐term stability of the implant as it needs to be reconfirmed in further clinical studies.
Influence of the Processing Conditions on the Morphology and the Mechanical Properties of Polyamide 6‐Carbon Fibre‐Carbon Nano Tube‐Compounds
Authors: Michaeli Walter , Hopmann Christian , Puch Florian 
Published: April 2014

SummaryPolyamide 6‐compounds containing carbon nano tubes and carbon fibres are prepared by melt compounding. To investigate the influence of the processing conditions on the mechanical properties and the morphology of carbon fibre reinforced polyamide 6‐nanocomposites the process parameters are varied while preparing the compounds. The processing conditions affect the mechanical properties and the morphology. The investigations reveal, that a micro‐nano‐compound with a PA6‐matrix should be compounded at a maximum barrel temperature of 260 °C, a throughput of 15 kg/h at a screw speed of 500 min−1 and a screw configuration, which introduces a low amount of shear energy into the compound. These processing conditions lead to a comparatively high specific mechanical energy input of 334 Wh/kg and to the best set of mechanical properties of the investigated materials. However, the morphology of the investigated carbon fibre reinforced nanocomposites does not show significant differences and has to be further investigated.
On MAC schemes on triangular delaunay meshes, their convergence and application to coupled flow problems
Authors: Eymard Robert , Fuhrmann Jürgen , Linke Alexander 
Published: April 2014

We study the convergence of two generalized marker‐and‐cell covolume schemes for the incompressible Stokes and Navier–Stokes equations introduced by Cavendish, Hall, Nicolaides, and Porsching. The schemes are defined on unstructured triangular Delaunay meshes and exploit the Delaunay–Voronoi duality. The study is motivated by the fact that the related discrete incompressibility condition allows to obtain a discrete maximum principle for the finite volume solution of an advection–diffusion problem coupled to the flow.The convergence theory uses discrete functional analysis and compactness arguments based on recent results for finite volume discretizations for the biharmonic equation. For both schemes, we prove the strong convergence in L2 for the velocities and the discrete rotations of the velocities for the Stokes and the Navier–Stokes problem. Further, for one of the schemes, we also prove the strong convergence of the pressure in L2.These predictions are confirmed by numerical examples presented in the article. © 2014 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 30: 1397–1424, 2014
Maternal obesity or weight loss around conception impacts hepatic fatty acid metabolism in the offspring
Authors: Nicholas Lisa M. , Rattanatray Leewen , Morrison Janna L. , Kleemann David O. , Walker Simon K. , Zhang Song , MacLaughlin Severence , McMillen I. Caroline 
Published: April 2014

ObjectiveTo determine the impact of maternal obesity or weight loss during the periconceptional period on programming of lipid metabolism in the liver of the offspring.MethodsAn embryo transfer model was used to investigate the effects of exposure to either maternal obesity and/or weight loss before and for 1‐week post‐conception on the abundance of key molecules regulating hepatic fatty acid oxidation and lipid synthesis in the 4‐month‐old lamb.ResultsPericonceptional maternal obesity resulted in decreased hepatic PPARα, PGC1α and GCN5 abundance and increased hepatic SIRT1 and AMPKα1, AMPKα2 and SREBP1 abundance in the offspring. Maternal weight loss in obese ewes did not ablate all of these effects of maternal obesity on hepatic metabolism in the lamb. Weight loss in normal weight ewes also resulted in decreased hepatic PGC1α and GCN5 and increased AMPKα2 abundance in the offspring.ConclusionsExposure of the oocyte/embryo to either maternal obesity or weight loss during the periconceptional period has long term consequences for hepatic lipid metabolism. These findings highlight the sensitivity of the early embryo to maternal nutrition and the need for dietary interventions which maximize metabolic benefits and minimize metabolic costs for the next generation.
The impact of obesity on subclinical coronary atherosclerosis according to the risk of cardiovascular disease
Authors: Lee Seung‐Yul , Chang Hyuk‐Jae , Sung Jimin , Kim Kwang Joon , Shin Sanghoon , Cho In‐Jeong , Shim Chi Young , Hong Geu‐Ru , Chung Namsik 
Published: April 2014

ObjectiveTo evaluate whether the association of obesity with coronary atherosclerosis depends on the risk of cardiovascular disease (CVD).MethodsA total of 1,406 asymptomatic Korean adults underwent both cardiac and abdominal multislice computed tomography (MSCT) as part of a routine health check‐up. Obesity was measured using body mass index (BMI), waist circumference (WC), and MSCT‐derived area/ratio of visceral and subcutaneous fat. The burden of CVD risk was assessed by the Framingham risk equation.ResultsIn the low‐risk group for CVD, obesity measurements (standardized odds ratio, 95% confidence interval) of BMI (1.406, 1.197‐1.652), WC (1.707, 1.434‐2.032), visceral fat area (1.700, 1.438‐2.009), and visceral‐to‐subcutaneous fat ratio (1.620, 1.379‐1.903) were associated with the presence of coronary calcification after adjusting for traditional CVD risks. But in the moderate‐to‐high risk group, the associations were attenuated. For additional adjustments of obesity measurements, in the low‐risk group, WC (1.717, 1.172‐2.514) and visceral‐to‐subcutaneous fat ratio (1.400, 1.029‐1.904) were independent determinants of coronary calcification.ConclusionsObesity is differentially associated with subclinical coronary atherosclerosis, according to the burden of CVD risk. In low‐risk adults, the relative distribution of abdominal fat, as well as whole body fat, is important to coronary atherosclerosis.
Indirect evidence for proton pump inhibitor failure in patients taking them independent of meals
Authors: Freigofas Julia , Haefeli Walter E. , Schöttker Ben , Brenner Hermann , Quinzler Renate 
Published: April 2014

ABSTRACTPurposeWe investigated the association between conditions of proton pump inhibitor (PPI) treatment failure and food intake in an elderly ambulatory population.MethodsOur data originate from a large population‐based cohort study. During a home visit done by a trained study physician, patients were asked for each medication to state whether it was taken in relation to a meal (before, concurrently with, and after) or independent of a meal. This information was analyzed for all patients taking a PPI daily and correlated to markers of PPI failure.ResultsOut of 2717 patients participating in a home visit and taking at least one medication, 383 took a PPI daily (14.1%). A PPI intake independent of meals was defined as incorrect and was observed in 64 patients, whereas 319 patients took their PPI in relation to a meal, which was defined as the correct intake. Treatment failure was observed in 10 out of 64 (15.6%) PPI users with incorrect intake and in 18 out of 319 (5.6%) PPI users with correct intake. The risk of treatment failure was threefold higher in patients taking their PPI independent of meals (OR 3.35; 95%CI 1.44–7.76).ConclusionThe higher risk for PPI failure in patients taking PPIs independent of meals suggests that synchronized PPI administration with meals is indeed essential, and better counseling of patients is needed. Copyright © 2014 John Wiley & Sons, Ltd.
Sample collection in clinical proteomics—Proteolytic activity profile of serum and plasma
Authors: Jambunathan Kalyani , Galande Amit K. 
Published: April 2014

PurposeProteolytic enzymes are promising diagnostic targets since they play key roles in diverse physiological processes and have been implicated in numerous human diseases. Human blood is a relatively noninvasive source for disease‐specific protease biomarker detection and subsequent translation into diagnostic tests. However, the choice of serum or plasma, and more specifically, which anticoagulant to choose in plasma preparation, is important to address in the sample preparation phase of biomarker discovery.Experimental designWe have previously utilized a combinatorial library of internally quenched fluorogenic probes to successfully map the global proteolytic profiles of various biological fluids. In this study, we utilized the platform to ascertain the impact of three commonly used anticoagulants (EDTA, heparin, and citrate) on the proteolytic activity profile of plasma and serum collected from a healthy Caucasian male.ResultsSerum and plasma citrate were observed to be most proteolytically active, followed by plasma heparin and then plasma EDTA. Detailed analysis of the amino acid distribution of motifs cleaved and not cleaved by the samples offered significant insights in to active proteolytic components within them.Conclusion and clinical relevanceBroad quantitative comparison of proteolytic profiles of these samples revealed several novel insights related to the differential substrate recognition of proteases present in these biological fluids.
General flexible nature of the cytosolic regions of fungal transient receptor potential (TRP) channels, revealed by expression screening using GFP‐fusion techniques
Authors: Ihara Makoto , Takano Yoshitaka , Yamashita Atsuko 
Published: April 2014

AbstractTransient receptor potential (TRP) channels are members of the voltage gated ion channel superfamily and display the unique characteristic of activation by diverse stimuli. We performed an expression analysis of fungal TRP channels, which possess relatively simple structures yet share the common functional characteristics with the other members, using a green fluorescent protein‐based screening methodology. The analysis revealed that all the tested fungal TRP channels were severely digested in their cytosolic regions during expression, implying the common flexibility of this region, as observed in the recent structural analyses of the fungal member, TRPGz. These characteristics are likely to be important for their diverse functions.