bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of VPAC1 receptor at the level of mRNA and protein in the porcine female reproductive system
Authors: Bukowski R. , Wąsowicz K. 
Published: May 2015

Abstract
The presence and distribution of vasoactive intestinal polypeptide (VIP) receptor VPAC1 was studied in the ovary, oviduct and uterus (uterine horn and cervix) of the domestic pig using methods of molecular biology (RT-PCR and immunoblot) and immunohistochemistry.
The expression of VPAC1 receptor at mRNA level was confirmed with RT-PCR in all the studied parts of the porcine female reproductive system by the presence of 525 bp PCR product and at the level of proteins by the detection of 46 kDa protein band in immunoblot. Immunohistochemical stainings revealed the cellular distribution of VPAC1 receptor protein. In the ovary it was present in the wall of arterial blood vessels, as well as in the ovarian follicles of different stages. In the tubular organs the VPAC1 receptor immunohistochemical stainings were observed in the wall of the arterial blood vessels, in the muscular membrane, as well as in the mucosal epithelium.
The study confirmed the presence of VPAC1 receptor in the tissues of the porcine female reproductive tract what clearly shows the possibility of influence of VIP on the porcine ovary, oviduct and uterus.
Analysis of Genetic Parameters on Ethiopian Mustard (Brassica Carinata A. Braun) Genotypes in Northwestern Ethiopia
Authors: Walle Tesfaye , Wakjira Adugna , Mulualem Tewodros 
Published: May 2015

ABSTRACT
This study was carried out with the objective to estimate the genotypic variability and other yield related traits of Ethiopian mustard in North West Ethiopia. A total of 36 genotypes of Ethiopian mustard were considered for this study. Analysis of variance was computed to contrast the variability within the collected genotypes based on yield and other yield related traits. The results revealed highly significant values(p<0.01) for days to maturity, grain filling period, number of pod per plot, secondary branches per plant, harvest index, seed yield per plot, seed yield per hectare and oil content. Significant differences (p<0.05) were noted for days to flowering, plant height, primary branch per plant, biomass per plot, oil yield per plot differences among the genotypes. Genotypic coefficient of variation (GCV %) was lower than phenotypic coefficient of variation (PCV %) for all the traits studied. High genetic advance with heritability was observed in the following characters; plant height, biomass of the plant, number of secondary branch per plant and grain filling period. There are variations in the extent of genetic variability, heritability and genetic advance of traits which can facilitate selection for further improvement of important traits of Ethiopian mustard. Therefore, it can be concluded that the variability within Ethiopian mustard genotypes collected from different areas of northern Ethiopia is high and vital for better crop improvement.
Aspects of the life history of the Atlantic poacher, Leptagonus decagonus, in Svalbard waters
Authors: Heggland Kristin , Meyer Ottesen Camilla A. , Berge Jørgen 
Published: May 2015

Abstract
The aim of the study is to describe aspects of the life history of the Atlantic poacher (Leptagonus decagonus) obtained during early October 2010 and late September 2011 from the Hinlopen Strait, located between Nordaustlandet and the Spitsbergen Archipelago. Length was measured for 142 individuals, and 82 out of these were weighed, sexed and the age in years determined. The sex distribution in the population was 45% females and 55% males. Gut content examination revealed the domination of the mesopelagic and hyper−benthic calanoid Bradyidius similis that was recorded in 87% of the stomachs analysed. Overall there was a significant difference in size (length and weight) between the sexes, and a difference in length and weight at age between the sexes. There was no difference in age distribution between the sexes, but there was a larger age range within the male population than in the female population. The sexual dimorphism in size is likely linked to different reproductive strategies. This study represents the first data on the life history of the Atlantic poacher in Svalbard waters.
Publication Ethics: Whose Problem is It?
Authors: Wager Elizabeth 
Published: May 2015

Abstract
Discussions about publication ethics often focus on misconduct by authors such as data fabrication and plagiarism. However, the roles of editors, publishers, academic societies, and research institutions should not be ignored. All these players have ethical responsibilities and should carefully consider the effects of their policies and actions. If people believe that publication ethics is 'somebody else's problem', little progress will be made and problems will persist.
Macedonian Journal of Chemistry and Chemical Engineering: Open Journal Systems - Editor's Perspective
Authors: Zdravkovski Zoran 
Published: May 2015

Abstract
The development and availability of personal computers and software as well as printing techniques in the last twenty years have made a profound change in the publication of scientific journals. Additionally, the Internet in the last decade has revolutionized the publication process to the point of changing the basic paradigm of printed journals. The Macedonian Journal of Chemistry and Chemical Engineering in its 40-year history has adopted and adapted to all these transformations. In order to keep up with the inevitable changes, as editor-in-chief I felt my responsibility was to introduce an electronic editorial managing of the journal. The choice was between commercial and open source platforms, and because of the limited funding of the journal we chose the latter. We decided on Open Journal Systems, which provided online submission and management of all content, had flexible configuration - requirements, sections, review process, etc., had options for comprehensive indexing, offered various reading tools, had email notification and commenting ability for readers, had an option for thesis abstracts and was installed locally. However, since there is limited support it requires a moderate computer knowledge/skills and effort in order to set up. Overall, it is an excellent editorial platform and a convenient solution for journals with a low budget or journals that do not want to spend their resources on commercial platforms or simply support the idea of open source software.
Genotype Variability and Haplotype Profile of Abcb1 (Mdr1) Gene Polymorphisms in Macedonian Population
Authors: Naumovska Zorica , Nestorovska Aleksandra K. , Sterjev Zoran , Filipce Ana , Dimovski Aleksandar , Suturkova Ljubica 
Published: May 2015

Abstract
The aim of this study was to evaluate the most common ABCB1 (MDR1, P-glycoprotein) polymorphisms in the population of R. Macedonia and compare the allele and haplotype frequencies with the global geographic data reported from different ethnic populations. The total of 107 healthy Macedonian individuals from the general population was included.
Genotypes for the ABCB1 for three polymorphisms C1236T [rs1128503], G2677A/T [rs2032582] and C3435T [rs1045642] were analyzed by Real-Time PCR. Obtained allele frequencies for these three SNPs were similar to those observed in other European Caucasians. The detected genotype frequencies were 33.6% for 1236CC, 44.9% for 1236CT and 21.5% for 1236TT in exon 12; 32.7%, 44.9% and 22.4% for 2677GG, 2677GT and 2677GT consecutively in exon 21; and 25.2% for 3435CC, 52.3% for 3435CT and 22.5% for 3435TT in exon 26. Strong LD was observed in our study among all three SNPs with the highest association confirmed for C1236T and G2677T ((D' = 0.859, r2 = 0.711). Eight different haplotypes were identified and the most prominent was the CGC haplotype (45.3%). Our study was the first to have documented the distribution of ABCB1 alleles, genotypes and haplotypes in the population of R. Macedonia. The obtained results can help in the prediction of different response to the drugs that are P-glycoprotein substrates. Additionally, in the era of individualized medicine the determination of the P-glycoprotein genotype might be a good predictive marker for determination of the subpopulations with higher risk to certain diseases.
Residential Development Activity In The Polish Legal Setting
Authors: Antczak - Stępniak Agata 
Published: May 2015

Abstract
Residential development in Poland has gone through many changes over the last few decades. In the 1990s, housing cooperatives played a major role among investors in the residential market, whereas developers were only taking their first steps. Today the situation has reversed. In addition to private persons building homes for their own use, developers contribute the most to the supply of new housing. There are many factors that have led to this situation. It is noteworthy that many laws governing the real estate market, the construction market, the development of entrepreneurship, etc. have been either enacted or frequently amended over the last two decades, which may have significantly affected developers’ activities.
The article is an attempt to answer the question about whether and, if so, how strongly changes in the legal setting have influenced residential development activity in Poland.
Fecal Calprotectin Dosage Value as A Diagnostic and Postoperative Marker in Diabetic Patients with Colorectal Cancer
Authors: Borza Ioan Lucian , Babes Aurel 
Published: May 2015

Abstract
Background and Aims: We evaluated fecal calprotectin values in patients with colorectal neoplasms undergoing surgery, comparatively in patients with and without diabetes mellitus. Material and Methods: We studied 40 patients operated for colorectal neoplasm, divided into two groups: one group of 20 patients with insulin-treated type 2 diabetes and another group of 20 patients without diabetes. Results: Patients had a high percentage of preoperative calprotectin test positivity (90%, 36 patients). A total of 19 patients in group 1 and 17 patients in group 2 had a positive calprotectin test. Postoperatively at 3 months, fecal calprotectin values remained elevated in 7 patients from group 1 and 4 patients from group 2. At 6 months postoperatively, fecal calprotectin values remained elevated in 2 patients from group 1 and 1 patient from group 2. Conclusions: Calprotectin values in faeces from patients with colorectal cancer were significantly increased, with a trend towards post-operatory normalization, slower in patients with diabetes. Fecal calprotectin value as a screening marker was almost equal compared to the hemoccult test, and better compared to that of the carcinoembryonic antigen.
The Importance of the Treatment Strategy Changes in the Long-Term Evolution of Type 2 Diabetic Patients with Sub-Optimal Glycaemic Control After Acute Coronary Syndrome
Authors: Trutz Johann , Babeș Aurel , Babeș Katalin 
Published: May 2015

Abstract
Background and Aims. Several factors are associated with a heightened risk of subsequent events, morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) after an acute coronary syndrome (ACS). Improving the management of these patients is a challenge that requires urgent attention. We aimed to study the long-term effect of the change in treatment strategy depending on the HbA1c level detected during the hospitalization for ACS. Material and methods. The primary endpoints of this study were the major adverse cardiac events (MACE) at 12 months. From the originally included 221 patients 15 were lost (no response to follow-up phone calls). The suboptimal glycaemic control group (HbA1c>7.0%, n=84) was divided in two subgroups: patients who completed a diabetological consult with further treatment changes (intervention group) and patients without this referral (control group). Results. No significant differences in baseline characteristics were found between the 2 subgroups. The second subgroup had a triple risk for a MACE in 1 year (HR=2.8704, 95% CI: 1.109-7.423, p=0.0296) compared to the intervention group. No significant differences were found in secondary endpoints. Conclusion. This study suggests that, after hospitalization for an ACS, diabetologist referral and treatment strategy changes are recommended for all T2DM patients whose HbA1c level is over 7% before discharge.
The Necessity to Evaluate the Needs of Type 2 Diabetes Patients and Nursing Intervention
Authors: Pătru Daniela , Preda Silviu Daniel , Pcela Agnesa , Voiculescu Călin Alexandru , Dionisie Simona , Moța Maria 
Published: May 2015

Abstract
Background and Aims: The aim of this paper was to demonstrate the necessity to evaluate the needs of patients with type 2 diabetes (assessing degrees of dependency) and nursing intervention for each of the 14 fundamental needs of human beings. Material and
method: The study was prospective and interventional, with a focus on educational methods, conducted over a period of 12 months on a group of 100 patients with type 2 diabetes. The stages of the study were: signing the informed consent, collecting data on a „nursing sheet”, statistical processing and analysis of the obtained results. Results: The distribution of cases according to the total degree of dependence in carrying out the fundamental needs shows that, regardless of the stage of disease evolution, no cases of independence or total severe dependence were registered. On hospital admission, the number of minimum total dependence cases was lower than at discharge while the number of cases of average total dependence was higher on admission than at discharge, regardless of the stage of disease evolution. Conclusions: The assessment of the 14 fundamental needs of patients with diabetes is necessary to identify the degree of dependence, to plan nursing interventions and to apply individualized care for each patient.
Current perspectives concerning the multimodal therapy in Glioblastoma
Authors: Grigore Florina , Brehar Felix Mircea , Gorgan Mircea Radu 
Published: May 2015

Abstract
GBM (Glioblastoma) is the most common, malignant type of primary brain tumor. It has a dismal prognosis, with an average life expectancy of less than 15 months. A better understanding of the tumor biology of GBM has been achieved in the past decade and set up new directions in the multimodal therapy by targeting the molecular paths involved in tumor initiation and progression. Invasion is a hallmark of GBM, and targeting the complex invasive mechanism of the tumor is mandatory in order to achieve a satisfactory result in GBM therapy. The goal of this review is to describe the tumor biology and key features of GBM and to provide an up-to-date overview of the current identified molecular alterations involved both in tumorigenesis and tumor progression.
Delayed neurological deterioration due to progressive pneumocephalus
Authors: Agrawal Amit , Kumar S. Satish , V. Umamaheswara Reddy 
Published: May 2015

AbstractPneumocephalus can develop immediately following head trauma or clinical presentation may be delayed for days. We report a case of 35 year male whose initial CT scan brain plain small specks of pneumocephalus in left para-sellar region. However the next day he was complaining of severe headache and had multiple episodes of vomiting. Repeat CT scan showed increase in the size of pneumocephalus including appearance of intraventricular air with mild cerebral edema. The patient recovered well with conservative management. The present case is a gentle reminder that in a subgroup of head injury patients, intracranial air can produce significant mass effect leading to tension pneumocephalus which can can behave like other intracranial mass lesions and causes worsening of the neurological status of these patients.
Professional Training of Future Teachers in Foreign Countries in Terms of Intercultural Interaction of Educational Space Objects
Authors: Desyatov Tymofiy 
Published: May 2015

Abstract The problem of professional training of teachers in foreign countries in terms of intercultural interaction of educational space objects has been studied in the paper. It has been stated that the current stage of human civilization development which is defined as the transition to a knowledge society, is characterized by qualitatively new requirements to the development of education. It has been noted that despite some cultural-and-historical differences in the development of Ukraine and countries of the European Union, functional similarity of national systems of teachers’professional training enables the usage of European experience in future teachers’ training. The role of teachers in the modernization of European education has been emphasized. It has been stated that in the professional training theory and practice significant experience has been accumulated which can form the basis for modernization of future teachers’ training for intercultural interaction of the educational process objects. Major trends in this area have been revealed. Scientific approaches and paradigms have been defined. Much attention is focused on the fact that a set of methodological approaches to the problem of teachers’ professional training has allowed to distinguish personality-centered and activity approaches as main ones for solving research problems. It has been noted that the reason for scientists’ special attention to the category of educational activities is the development of problems related to organizing cross-cultural educational process that helps students to get knowledge about other cultures, to determine the common and special features in traditions, lifestyle and cultural values of peoples, to bring up youth in the spirit of respect for systems of other cultures. Much attention has been paid to the concept of educational support which is a humanistic way of interaction of a teacher with students on the basis of expansion and deepening student-centered and developmental paradigm of education which is based on internal freedom and creativity of the individual, real humanism and democracy.
Problems of Technical Standards Teaching in the Context of the Globalization and Euro-Integration in Higher Education System of Ukraine
Authors: Kornuta Olena , Pryhorovska Tetiana 
Published: May 2015

Abstract Globalization and Ukraine association with EU imply including Ukrainian universities into the world scientific space. The aim of this article is to analyze the problem of drawing standards teaching, based on the experience of Ivano-Frankivsk National Technical University of Oil and Gas (Ukraine) and to summarize the experience of post Soviet states in a field of the new technical standards implementation. Experience of post Soviet states showed necessity to gradual transition to new standards. Based on this experience, main fundamental principles for new standards and technical regulations harmonization have been presented. The main directions of improving the system of personnel training and retraining in this field are: changing the educational institutions syllabuses to in-depth study of new standards and regulations and the skills to apply them in practice, monitoring the quality of educational programs of secondary and higher educational institutions; development of training programs for engineers and other technical personnel of basic new standards and regulations; compliance training programs and syllabuses for engineers, relevant to international training programs and syllabuses (taking into account the laws and traditions of the technical education in Ukraine); development of the national standards of education and certification on the basis of international standards.
Comparative Analysis of Theoretical Approaches to Professional Training of the Future Customs Officers in the System of Higher Education of Ukraine and Poland
Authors: Korzhynska Tetiana 
Published: May 2015

Abstract The article deals with the content of future customs officers’ professional training. Such notions as “training”, “specialists’ professional training”, “customs officers’ professional training”. The article presents an overview of the scientific literature, theoretical analyzes of materials concerning the issues of future customs officers’ professional training in the higher educational institutions of Ukraine and the Republic of Poland, still remaining open. The major scientific approaches of leading domestic and foreign scientists to study future customs officers’ professional training have been characterized, in particular competence approach, functional approach, instrumental approach, learner-centred approach, axiological approach, historical and systematic-andcomprehensive approaches, theoretical generalization The conception of the research problem in the educational sphere of higher educational institutions has been theoretically generalised. The point of the article is focused on the fact that professional training of future specialists of customs authorities is a process of learning, understanding and specific knowledge, skills and proficiencies of future customs officers who perform the functions of future professional activities, fulfil their functions in accordance with their professional duties during customs service. Also it has been noted that professional training of future customs specialists is caused by personal, practical, functional, historical factors that it is important in the process of understanding this phenomenon and in the research and development processes.
Circulating influenza viruses and the effectiveness of seasonal influenza vaccine in Romania, season 2012-2013 / Virusurile gripale circulante și eficacitatea vaccinului gripal sezonier în România, în sezonul 2012-2013
Authors: Pitigoi Daniela , Necula George , Alexandrescu Viorel , Mihai Maria Elena , Cherciu Carmen Maria , Tecu Cristina , Popovici Odette , Popescu Rodica , Lupulescu Emilia 
Published: May 2015

AbstractBackgound. Using influenza epidemiological and virological surveillance data, we aimed at investigating the profile of influenza viruses circulating in Romania during the season 2012-2013 and estimating the effectiveness (VE) of the seasonal vaccine. Methods. We tested all specimens collected from patients with influenza like illness (ILI) in the national surveillance system between week 40/2012 to week 20/2013. Influenza A/B positive specimens identified by molecular detection (RT-PCR) were further characterized. We used hemagglutination inhibition assay for antigenic characterization and chemiluminiscence assay for the antiviral susceptibility testing. Subsequently we conducted nucleotide sequencing of hemagglutinin and neuraminidase genes and phylogenetic tree analyses. We estimated influenza VE using the test negative case-control study design, as 1-odds ratio of vaccination among ILI cases positive for influenza and ILI negative controls. Results and Discussions. We tested 1087 specimens, and 537 cases were positive (56.2% influenza B, 40.6% A(H1N1)pdm09, 3.2% A(H3N2). Sixty-four influenza viruses were antigenically and/or genetically characterized. A(H1N1)pdm09 viruses were related to the vaccine strain A/ California/07/2009 and clustered with genetic group 6 similar to A/St. Petersburg/27/2011. Influenza B viruses belonged to clade 2 of type B/Yamagata lineage, related to B/Estonia/55669/2011 except one, B/Victoria lineage, representative strain B/Brisbane/60/2008. A(H3) viruses clustered with group 3C of the A/Victoria/208/2009 clade, similar to the vaccine strain A/Victoria/361/2011. All tested strains (57) demonstrated susceptibility to oseltamivir and zanamivir. The adjusted seasonal influenza vaccine effectiveness against influenza A(H1N1)pdm09 (N=119) was 76.9% (95% CI: -113.4, 98.5), suggesting a good protection, consistent with the good match between the vaccine and circulating strains.