bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiphospholipid syndrome, monoclonal gammopathy, and cryoglobulinemia overlap leading to recurrent cutaneous microvascular thrombosis: A case report and retrospective cohort study
Authors: Bohm Alexandra , Wan Bo Angela , Karin Amir , Lee Lauren J. , Lee Agnes Y. Y. , Conway Edward M. , Lai Chieh Min Benjamin 
Published: July 2024

AbstractAntiphospholipid syndrome (APS), cryoglobulinemia, and monoclonal gammopathies are variably accompanied by thrombotic complications. We describe a patient with recurrent skin microvascular thrombosis, APS, cryoglobulinemia, marginal zone lymphoma, and IgMκ monoclonal gammopathy, responsive to chemoimmunotherapy. The cryoglobulin fraction contained the IgMκ paraprotein, while antiphospholipid antibodies (aPL) were predominantly in the cryosupernatant. A retrospective analysis of aPL‐positive patients in our institution showed that 8.1% co‐expressed monoclonal gammopathy. These overlap patients had thrombotic complications and most had recurrences. Patients with multiple gammopathies of thrombotic significance may have several autoantibodies and constitute a high‐risk group.
Internal governance challenges of young independent coffee cooperatives in south‐west Ethiopia
Authors: Mswaka Walter , Snell Matthew , Wood Adrian 
Published: August 2024

AbstractThis study analyses the internal governance practices of coffee marketing cooperatives in south‐west Ethiopia. The investigation argues that there is a need to go beyond democratic governance practices in order to understand the governance of these cooperatives working in multi‐stakeholder environments where the state is powerful and intervenes in their operations. The study concludes that the actions of internal and external actors have resulted in unique governance structures that profoundly influence their operations.
Crop mapping and quantitative evaluation of cultivated land use intensity in Shandong Province, 2018–2022
Authors: Zhao Jinchang , Sun Xiaofang , Wang Meng , Li Guicai , Hou Xuehui 
Published: August 2024

AbstractIndustrialization and urbanization have intensified land‐use pressures on agroecosystems. Monitoring cultivated land use intensity (CLUI) is crucial for implementing sustainable agriculture. However, current agroecosystem management in Shandong Province lacks high‐resolution CLUI information. To address this gap, this study measured and analyzed CLUI at a 1‐km scale in Shandong Province from 2018 to 2022, using self‐produced crop maps and the human appropriation of net primary production (HANPP) framework. The spatial autocorrelation model was used to analyze the spatiotemporal pattern and aggregation characteristics of cultivated land use intensity. The influencing factors of CLUI were analyzed using the propensity score matching method, which helps reduce the interference of confounding factors. The results are as follows: (1) The wheat‐maize planting pattern in Shandong Province has remained relatively stable, with a notable trend toward intensified cultivation in the western region. (2) CLUI exhibited notable spatial and temporal heterogeneity, with low and medium values predominantly located in the western region. CLUI increased from 1.13 to 1.24, exceeding the global average of 0.84. (3) CLUI showed significant spatial aggregation characteristics. In 2018, 2020, and 2022, the western region was mainly characterized by high‐high and high‐low types. In 2019 and 2021, it was mainly characterized by the low‐low type, with less prevalence of low‐high type. The center of gravity of high‐high and low‐high types shifted southwest, whereas that of high‐low and low‐low types shifted northeast. (4) Chemical fertilizers, pesticides, and plastic mulch exhibited significant positive correlations with CLUI, whereas temperature and precipitation showed significant negative correlations. Favorable natural conditions can mitigate human interference, leading to lower CLUI.
Light Field Transformation of Metasurface Based on Arbitrary Jones Matrix
Authors: Zhang Xiaotong , Li Xin , Zhang Shifei , Zhao Ruizhe , Wang Yiqun , Chen Chen , Wang Yongtian , Huang Lingling 
Published: July 2024

AbstractMetasurfaces are ultra‐thin micro‐nano elements, have abundant freedoms, and are widely used in light field transformation. The Jones matrix of single‐layer birefringent metasurfaces have at most 6 degrees of freedom, which limits the richness and diversity of light field transformation. Bilayer metasurfaces have more design channels and functionality than single‐layer metasurfaces. By mathematical derivation, the decomposition method of the bilayer metasurface unitary Jones matrix is provided. Further, inspired by double‐phase holography, arbitrary complex Jones matrix is decomposed and realized by bilayer metasurface and achieves analytical decoupling of all 4 complex components of the Jones matrix. As the theoretical verification, spin‐orbit angular momentum mapping and four‐channel complex holography are realized by the bilayer metasurface. The decomposition method is completely analytical, universal, and easy to implement. It is of great significance for the transformation of light field, information transmission, and optical encryption based on metasurfaces.
The role of mesenchymal stem cells in cancer and prospects for their use in cancer therapeutics
Authors: Tang Jian , Chen Yu , Wang Chunhua , Xia Ying , Yu Tingyu , Tang Mengjun , Meng Kun , Yin Lijuan , Yang Yang , Shen Liang , Xing Hui , Mao Xiaogang 
Published: July 2024

AbstractMesenchymal stem cells (MSCs) are recruited by malignant tumor cells to the tumor microenvironment (TME) and play a crucial role in the initiation and progression of malignant tumors. This role encompasses immune evasion, promotion of angiogenesis, stimulation of cancer cell proliferation, correlation with cancer stem cells, multilineage differentiation within the TME, and development of treatment resistance. Simultaneously, extensive research is exploring the homing effect of MSCs and MSC‐derived extracellular vesicles (MSCs‐EVs) in tumors, aiming to design them as carriers for antitumor substances. These substances are targeted to deliver antitumor drugs to enhance drug efficacy while reducing drug toxicity. This paper provides a review of the supportive role of MSCs in tumor progression and the associated molecular mechanisms. Additionally, we summarize the latest therapeutic strategies involving engineered MSCs and MSCs‐EVs in cancer treatment, including their utilization as carriers for gene therapeutic agents, chemotherapeutics, and oncolytic viruses. We also discuss the distribution and clearance of MSCs and MSCs‐EVs upon entry into the body to elucidate the potential of targeted therapies based on MSCs and MSCs‐EVs in cancer treatment, along with the challenges they face.
Development of potent pan‐coronavirus fusion inhibitors with a new design strategy
Authors: Zhu Yuanmei , Gao Zhongcai , Feng Xiaoli , Cheng Lin , Liu Nian , Liu Chao , Han Shaowei , Yang Qiaojiang , Zou Qingcui , Chong Huihui , Zhang Zheng , Li Minghua , Song Gengshen , He Yuxian 
Published: July 2024

AbstractDevelopment of potent and broad‐spectrum drugs against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) remains one of the top priorities, especially in the cases of the emergence of mutant viruses and inability of current vaccines to prevent viral transmission. In this study, we have generated a novel membrane fusion‐inhibitory lipopeptide IPB29, which is currently under clinical trials; herein, we report its design strategy and preclinical data. First, we surprisingly found that IPB29 with a rigid linker between the peptide sequence and lipid molecule had greatly improved α‐helical structure and antiviral activity. Second, IPB29 potently inhibited a large panel of SARS‐CoV‐2 variants including the previously and currently circulating viruses, such as Omicron XBB.5.1 and EG.5.1. Third, IPB29 could also cross‐neutralize the bat‐ and pangolin‐isolated SARS‐CoV‐2‐related CoVs (RatG13, PCoV‐GD, and PCoV‐GX) and other human CoVs (SARS‐CoV, MERS‐CoV, HCoV‐NL63, and HCoV‐229E). Fourth, IPB29 administrated as an inhalation solution (IPB29‐IS) in Syrian hamsters exhibited high therapeutic and preventive efficacies against SARS‐CoV‐2 Delta or Omicron variant. Fifth, the pharmacokinetic profiles and safety pharmacology of IPB29‐IS were extensively characterized, providing data to support its evaluation in humans. In conclusion, our studies have demonstrated a novel design strategy for viral fusion inhibitors and offered an ideal drug candidate against SARS‐CoV‐2 and other coronaviruses.
Antibody–drug conjugates in cancer therapy: mechanisms and clinical studies
Authors: He Jun , Zeng Xianghua , Wang Chunmei , Wang Enwen , Li Yongsheng 
Published: July 2024

AbstractAntibody–drug conjugates (ADCs) consist of monoclonal antibodies that target tumor cells and cytotoxic drugs linked through linkers. By leveraging antibodies’ targeting properties, ADCs deliver cytotoxic drugs into tumor cells via endocytosis after identifying the tumor antigen. This precise method aims to kill tumor cells selectively while minimizing harm to normal cells, offering safe and effective therapeutic benefits. Recent years have seen significant progress in antitumor treatment with ADC development, providing patients with new and potent treatment options. With over 300 ADCs explored for various tumor indications and some already approved for clinical use, challenges such as resistance due to factors like antigen expression, ADC processing, and payload have emerged. This review aims to outline the history of ADC development, their structure, mechanism of action, recent composition advancements, target selection, completed and ongoing clinical trials, resistance mechanisms, and intervention strategies. Additionally, it will delve into the potential of ADCs with novel markers, linkers, payloads, and innovative action mechanisms to enhance cancer treatment options. The evolution of ADCs has also led to the emergence of combination therapy as a new therapeutic approach to improve drug efficacy.
An optimization‐based Monte Carlo method for estimating the two‐terminal survival signature of networks with two component classes
Authors: Lopes da Silva Daniel B. , Sullivan Kelly M. 
Published: July 2024

AbstractEvaluating two‐terminal network reliability is a classical problem with numerous applications. Because this problem is ‐Complete, practical studies involving large systems commonly resort to approximating or estimating system reliability rather than evaluating it exactly. Researchers have characterized signatures, such as the destruction spectrum and survival signature, which summarize the system's structure and give rise to procedures for evaluating or approximating network reliability. These procedures are advantageous if the signature can be computed efficiently; however, computing the signature is challenging for complex systems. With this motivation, we consider the use of Monte Carlo (MC) simulation to estimate the survival signature of a two‐terminal network in which there are two classes of i.i.d. components. In this setting, we prove that each MC replication to estimate the signature of a multi‐class system entails solving a multi‐objective maximum capacity path problem. For the case of two classes of components, we adapt a Dijkstra's‐like bi‐objective shortest path algorithm from the literature for the purpose of solving the resulting bi‐objective maximum capacity path problem. We perform computational experiments to compare our method's efficiency against intuitive benchmark approaches. Our computational results demonstrate that the bi‐objective optimization approach consistently outperforms the benchmark approaches, thereby enabling a larger number of MC replications and improved accuracy of the reliability estimation. Furthermore, the efficiency gains versus benchmark approaches appear to become more significant as the network increases in size.
A dynamic programming algorithm for order picking in robotic mobile fulfillment systems
Authors: Justkowiak Jan‐Erik , Kovalyov Mikhail Y. , Pesch Erwin 
Published: July 2024

AbstractThe order scheduling and rack sequencing problem deals with the order picking process in robotic mobile fulfillment systems: automated guided vehicles lift and transport movable storage racks to picking stations to supply items requested by customer orders which are put together in cardboard boxes on a workbench of limited capacity. To efficiently operate the station, the sequence in which racks visit the station one after another and the intervals at which customer orders are scheduled must be coordinated. We present a dynamic programming algorithm for the order scheduling and rack sequencing problem at a single picking station minimizing the number of rack visits. Despite monolithic mixed integer linear programming formulations, our approach appears to be the first combinatorial solution method for the problem in literature. A computational study demonstrates the effectiveness of the approach.
Urban residents' knowledge of and attitudes and willingness to control woody invasive alien plants in their domestic gardens in South Africa
Authors: Seboko T. , Shackleton C. M. , Ruwanza S. 
Published: August 2024

Abstract

Invasive alien species are considered a major contributor to biodiversity loss. Yet, many are favoured for particular ecosystem services that they provide. This is often so in urban environments experiencing rapid environmental and social change and land transformation. Public support is viewed as critical for invasive alien species prevention and management. Furthermore, it is assumed that local citizens are more likely to be willing and ready to engage if they are informed about the costs and benefits associated with invasive alien species. However, the use of, and attitudes towards, invasive alien species in urban areas is poorly understood, especially regarding urban gardens under private ownership and control. This lack of understanding is likely to compromise potential management interventions.

Here, we report on a survey of 240 people across 12 small towns in the Eastern Cape province of South Africa to determine their knowledge and perceptions regarding woody invasive alien plants (IAPs), their willingness to engage in control and how these vary in relation to respondent attributes.

The findings indicated that respondents have low levels of knowledge about woody IAPs despite 84% of them having at least one woody IAP species in their garden. Nineteen different woody IAPs were noted across the sample of 240 households. A wide range of ecosystem services and disservices from woody IAPs were mentioned. Because of the benefits provided, or the effort required to remove them, only 56% of respondents were willing to have the woody IAPs removed from their gardens, with most considering it the responsibility of government agencies to do so. There was a positive association between the levels of education, income, and the impression that woody IAPs pose a problem and being aware of the term, but not willingness to remove them.

Synthesis and implications. These results reveal the complex relationship that urban citizens have with IAPs in garden settings, and for authorities to consider appropriate and targeted awareness campaigns if control strategies are to be successful.

Read the free Plain Language Summary for this article on the Journal blog.
Multi‐walled carbon nanotubes doped with Phytocompounds of Centella asiatica for food packing applications and their anti‐microbial properties
Authors: Sivakumar Santhini , Hema T. A. 
Published: July 2024

AbstractCentella asiatica phytocompounds coated onto Multi‐Walled Carbon Nanotube (MWCNT) possessing antibacterial activity were prepared using a simple physical absorption method. The incorporation of Centella asiatica phytocompounds into functionalized MWCNTs could improve the physical properties of Centella asiatica phytocompounds conjugated MWCNT compared to pure MWCNT. Fourier Transform Infrared Spectroscopy (FTIR) results depict the presence of bioactive compounds on MWCNT coatings and the Raman spectrum confirms the presence of carbon in various ranges by their peaks from 636 to 1594.46 cm−1 in the MWCNT. Scanning Electron Microscope (SEM) micrograph images confirmed the existence of MWCNT‐Nano composites with Centella asiatica phytocompounds exhibiting the surface structure with pore clarity and visible pipes. Transmission Electron Microscope (TEM) images show the uniform dispersed spherical ultrathin nanosheets at the size of 10–20 nm. Further anti‐bacterial analysis results revealed that Centella asiatica phytocompounds coating enhances the anti‐bacterial activity of MWCNT. Prepared Centella asiatica phytocompounds ‐MWCNT possess maximal inhibition and produces high zones of inhibition 11 ± 0.06, 17 ± 0.08, 14 ± 0.07, and 16 ± 0.08 mm against four food‐spoiling bacterial clinical pathogens Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia respectively. Centella asiatica phytocompounds conjugated‐MWCNT spin‐coated packaging showed good preservation properties. Centella asiatica phytocompounds conjugated with MWCNTs provide antimicrobial properties, enabling the development of novel food packaging materials that can protect food from spoilage, increase food stability, and sustainability, and improve the shelf life of food.
Spatial metabolomics method to reveal the differences in chemical composition of raw and honey‐fried Stemona tuberosa Lour. by using UPLC‐Orbitrap Fusion MS and desorption electrospray ionization mass spectrometry imaging
Authors: Xiong Haixuan , Sun Shuding , Zhang Weiwei , Zhao Di , Liu Xuefang , Tian Yange , Feng Suxiang 
Published: July 2024

AbstractIntroductionStemona tuberosa Lour. (ST) is a significant traditional Chinese medicine (TCM) renowned for its antitussive and insecticidal properties. ST is commonly subjected to processing in clinical practice before being utilized as a medicinal substance. Currently, the customary technique for processing ST is honey‐fried. Nevertheless, the specific variations in chemical constituents of ST before and after honey‐fried remain unclear.ObjectiveThis work aimed to analyze the variations in chemical constituents of ST before and after honey‐fried and to study the distribution of differential markers in the roots.MethodsUPLC‐Orbitrap Fusion MS combined with molecular network analysis was used to analyze the metabolome of ST and honey‐fried ST (HST) and to screen the differential metabolites by multivariate statistical analysis. Spatial metabolomics was applied to study the distribution of differential metabolites by desorption electrospray ionization mass spectrometry imaging (DESI‐MSI).ResultsThe ST and HST exhibited notable disparities, with 56 and 61 chemical constituents found from each, respectively. After processing, the types of alkaloids decreased, and 12 differential metabolites were screened from the common compounds. The notable component variations were epibisdehydro‐tuberostemonine J, neostenine, tuberostemonine, croomine, neotuberostemonine, and so forth. MSI visualized the spatial distribution of differential metabolites.ConclusionsOur research provided a rapid and effective visualization method for the identification and spatial distribution of metabolites in ST. Compared with the traditional method, this method offered more convincing data supporting the processing mechanism investigations of Stemona tuberosa from a macroscopic perspective.
Effect of spandex linear density and twist multiplier on the properties of core spun yarn and denim fabric
Authors: Hassan Md. Nahid , Rokonuzzaman Md. , Razzaque Abdur , Rahim Md. Abdur , Hossain Alimran , Islam Tarikul 
Published: July 2024

AbstractThe utilization of core‐spun yarns with spandex has achieved significant interest over the past decade because of their exceptional stretchability, resilience, and comfort features. The main objective of this study was to evaluate the effects of changing the spandex denier and twist multiplier on the physio‐mechanical properties of 16 Ne core spun yarn and the produced denim fabric using these yarns as weft. Core‐spun yarns were produced from three different spandex deniers at various TM values, where cotton roving was used as the sheath. Fabrics were manufactured using an air‐jet weaving machine with the core spun yarn as weft and 100% ring cotton yarn as warp (12 Ne) following the identical 3/1 twill weave pattern. Results reveal that using different spandex percentages shows better results at different TM parameters. Both yarn and fabric were attained at a twist multiplier of 5.0, 5.5, and 6.0 for 40, 70, and 105 D, respectively. Additionally, it was discovered that the yarn produced using lower spandex denier gives higher tenacity for yarn and fabric. However, the yarn produced using a higher spandex denier gives higher elongation percentage for yarn, higher tear strength, recovery, and lower growth percentage fabric.Highlights
Influence of spandex denier and twist multiplier on the physio‐mechanical properties of core‐spun yarn and the resulting denim fabric.
The higher spandex denier exhibited greater tear strength, better recovery, and lower fabric growth percentages.
Increasing the twist multiplier initially increased the tenacity and elongation percentage of yarns and fabrics, followed by a decrease.
Higher spandex percentages reduced hairiness and increased with higher twist levels.
Higher spandex denier indicates the need for tailored TM settings based on spandex denier to achieve desired fabric properties.
Influence of chemical treatment of fly ash on mechanical, thermal, and water absorption characteristics of PS/SBC nanocomposite
Authors: Rabbi Md. Sanaul , Rahman Tauhidur , Roshid M. M. , Siddiqui M. A. Shadab 
Published: August 2024

AbstractThe purpose of this study is to investigate the effective chemical treatment of fly Ash (FA) that affects the mechanical, thermal, and water absorption capabilities of polystyrene/styrene‐butadiene‐copolymer (PS/SBC) nanocomposites. NaOH, H2SO4 and distilled water have been employed to conduct the chemical treatment. Specimens have been prepared using injection molding technique. In order to evaluate the mechanical properties of the material, tensile, flexural, impact, and hardness tests were carried out. thermo‐gravimetric analysis (TGA) and differential thermal analysis (DTA) were employed to gain an understanding of the thermal behavior of the material. Furthermore, to determine the moisture resistance, water absorption experiments were conducted. Experimental results show that, alkali‐treated FA (AL‐FA) demonstrated the maximum values with an ultimate tensile strength of 26.68 MPa, acid‐treated FA (AC‐FA) composite exhibiting the highest flexural strength at 5 MPa whereas water‐treated FA (WA‐FA) composite led to better impact strength of 17.6 kJ/m2. TGA revealed that WA‐FA and AL‐FA composites experienced an 80% reduction in weight at 500°C, while AC‐FA composites exhibited weight reductions of 90%. The significance of treatment methods in interfacial interactions between the polymer and FA has been studied through morphological analysis. These findings provide valuable insights that can be applied to future research and industrial applications in the field of sustainable materials engineering.Highlights
Polystyrene/Styrene‐Butadiene‐Copolymer composites were prepared with Fly ash (FA) filler.
FA pre‐treated by NaOH (AL‐FA), H2SO4 (AC‐FA) and distilled water (WA‐FA).
Injection molding technique was employed to prepare the ASTM standard samples.
WA‐FA composite exhibited the highest ductility but lower tensile strength.
TGA revealed that AC‐FA composites exhibited weight reductions of 90%.