bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dendritic fibromyxolipoma in the right inguinal and perineum regions: a case report and review of the literature
Authors: Zhang Xing Jian , Zhou Song , Nie Kai , Chen Da Feng , Kui Guo Ju , Zhang Xue Hui 
Published: September 2013

Abstract

Abstract
A 32-year-old woman presented with a slow-growing, painless, subcutaneous lesion in the right inguinal and perineum regions. The mass was 24.0 cm × 10.5 cm × 5.0 cm in size, well circumscribed, mobile, and rubbery. Microscopically, the resected mass was mainly composed by a proliferation of small spindle or stellate cells, variably admixed with mature adipose tissue, embedded within an abundant myxoid and collagenized stroma. Immunohistochemically, the spindle and stellate cells were strongly positive for vimentin, CD34, and bcl-2 antibodies but not for smooth muscle actin and desmin. The tumor was diagnosed as dendritic fibromyxolipoma based on the typical findings of histology and immunohistochemistry. Clinical follow-up of 9 months after surgery revealed no evidence of recurrence. We report the first case of dendritic fibromyxolipoma in the right inguinal and perineum regions and discuss the different diagnosis.

Virtual slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1313680868103019.
Identification of aberrant microRNA expression pattern in pediatric gliomas by microarray
Authors: Liu Fatao , Xiong Yuyu , Zhao Yang , Tao Liming , Zhang Zhou , Zhang Hong , Liu Yun , Feng Guoyin , Li Baojie , He Lin , Ma Jie , Qin Shengying , Yang Yifeng 
Published: September 2013

Abstract

Background
Brain tumor remains the leading cause of disease-related death in children. Many studies have focused on the complex biological process involved in pediatric brain tumors but little is know about the possible role of microRNAs in the genesis of these tumors.

Methods
In this study, we used a microRNA microarray assay to study the expression pattern of microRNAs in pediatric gliomas and matched normal tissues.

Results
We found 40 differentially expressed microRNAs, among which miR-1321, miR-513b, miR-769-3p were found be related to cancer genesis for the first time. The expression of selected microRNAs were then confirmed by qRT-PCR. Furthermore, GO and pathway analysis showed that the target genes of the 40 differentially expressed microRNAs were significantly enriched in nervous system-related and tumor-related biological processes and signaling pathways. Additionally, an apoptosis-related network of microRNA–mRNA interaction, representing the critical microRNAs and their targets, was constructed based on microRNA status.

Conclusions
In the present study we identified the changed expression pattern of microRNAs in pediatric gliamas. Our study also provides a better understanding of pediatric brain tumor biology and may assist in the development of less toxic therapies and in the search for better markers for disease stratification.

Virtual slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1323049861105720
Sudden death of an infant with cardiac, nervous system and genetic involvement – a case report
Authors: Mecchia Donatella , Casale Valentina , Oneda Roberta , Matturri Luigi , Lavezzi Anna Maria 
Published: September 2013

Abstract

Abstract
We present a case of sudden death of a 1-month-old male infant with heart, brainstem and genetic polymorphism involvement. Previously considered quite healthy, the child died suddenly and unexpectedly during sleep. The autopsy protocol included an in-depth anatomopathological examination of both the autonomic nervous system and the cardiac conduction system, and molecular analysis of the serotonin transporter gene promoter region, in which a specific genetic condition seems to be associated with sudden infant death. Histological examination revealed the presence of congenital cardiac alterations (hypertrophic cardiomyopathy and an accessory Mahaim fiber in the cardiac conduction system), severe hypodevelopment of all the raphe nuclei and a heterozygous genotype L/S related to the serotonin transporter gene. The sudden death of this infant was the unavoidable outcome of a complex series of congenital anomalies, each predisposing to SIDS.

Virtual slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3480540091031788
Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review
Authors: Gancheva Katya , Virchis Andres , Howard-Reeves Julie , Cross Nick CP , Brazma Diana , Grace Colin , Kotzampaltiris Paul , Partheniou Fedra , Nacheva Elisabeth 
Published: September 2013

Abstract

ETV6-ABL1 is a rare gene fusion with oncogenic properties, reported so far in 28 patients presenting a variety of haematological malignancies associated with clinical outcome, including chronic myeloid leukaemia (CML), acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL) and chronic myeloproliferative neoplasm (cMPN). Here we report on a 46-year-old female who presented with Philadelphia negative CML, positive for the ETV6-ABL1 fusion. Whole genome screening carried out with oligonucleotide arrays showed a subtle loss at 12p13 and cryptic imbalances within the 9q34.3 region in a highly unstable genome. FISH mapping with custom BAC probes identified two breakpoints 5 Mb apart within the 9q34 region, together with a break at 12p13. While FISH with commercial BCR-ABL1 probes failed to detect any ABL1 changes, the ETV6 break-apart probe conclusively identified the ETV6-ABL1 fusion thus determining the probe’s role as the primary diagnostic FISH test for this chimeric oncogene. In addition, we confirm the association of the ETV6-ABL1 fusion with imatinib resistance reported so far in three other patients, while recording excellent response to the 2nd generation tyrosine kinase inhibitor (TKI) nilotinib. In summary, we highlight the value of ETV6 FISH as a diagnostic test and the therapy resistance of ETV6-ABL1 positive disorders to imatinib.
The recent decline in employment dynamics
Authors: Hyatt Henry R , Spletzer James R 
Published: September 2013

Abstract
We document and attempt to explain the recent decline in employment dynamics in the U.S. We have four major empirical findings. First, each measure exhibits a “stair step” pattern, with the declines concentrated in recessions and little increase during subsequent expansions. Second, changes in the composition of workers and businesses can explain only a small amount of the decline. Third, any explanation for the decline in job creation and job destruction will account for no more than one-third of the decline in hires and separations. Fourth, the decline in hires and separations is driven by the disappearance of short-duration jobs.

JEL Codes

E24, J63
The impact of cultural diversity on firm innovation: evidence from Dutch micro-data
Authors: Ozgen Ceren , Nijkamp Peter , Poot Jacques 
Published: September 2013

Abstract
An important question for firms and policy makers is whether the recruitment of
foreign workers can boost innovation. Migration studies have demonstrated
positive economic impacts of cultural diversity on productivity and innovation
at the regional level, but the impacts at firm level are less well known.
Merging data from four different sources, provided by Statistics Netherlands, we
construct and analyze a unique linked employer-employee micro dataset of 4582
firms that includes qualitative information on firm innovation. We consider both
the number of immigrants these firms employ and their cultural diversity.
Potential endogeneity of migrant employment is addressed by an instrumental
variables approach that accounts for the past geographic distribution of
immigrants and the past culinary diversity of the municipality the firm is
located in. We find robust evidence that firms employing relatively more
migrants are less innovative. However, there is evidence of integration in that
this effect is generally less strong or even absent for second generation
immigrants. Moreover, firms employing a more diverse foreign workforce are more
innovative, particularly in terms of product innovations. The benefits of
diversity for innovation are more apparent in sectors employing relatively more
skilled immigrants.

JEL codes

D22, F22, O31
Development and Standardization of a Furosemide Stress Test to Predict the Severity of Acute Kidney Injury
Authors: Chawla Lakhmir S , Davison Danielle L , Brasha-Mitchell Ermira , Koyner Jay L , Arthur John M , Shaw Andrew D , Tumlin James A , Trevino Sharon A , Kimmel Paul L , Seneff Michael G 
Published: September 2013

Abstract
Introduction
In the setting of early acute kidney injury (AKI), no test has been shown to definitively predict the progression to more severe stages.

Methods
We investigated the ability of a furosemide stress test (FST) (one-time dose of 1.0 or 1.5 mg/kg depending on prior furosemide-exposure) to predict the development of AKIN Stage-III in 2 cohorts of critically ill subjects with early AKI. Cohort 1 was a retrospective cohort who received a FST in the setting of AKI in critically ill patients as part of Southern AKI Network. Cohort 2 was a prospective multicenter group of critically ill patients who received their FST in the setting of early AKI.

Results
We studied 77 subjects; 23 from cohort 1 and 54 from cohort 2; 25 (32.4%) met the primary endpoint of progression to AKIN-III. Subjects with progressive AKI had significantly lower urine output following FST in each of the first 6 hours (p<0.001). The area under the receiver operator characteristic curves for the total urine output over the first 2 hours following FST to predict progression to AKIN-III was 0.87 (p = 0.001). The ideal-cutoff for predicting AKI progression during the first 2 hours following FST was a urine volume of less than 200mls(100ml/hr) with a sensitivity of 87.1% and specificity 84.1%.

Conclusions
The FST in subjects with early AKI serves as a novel assessment of tubular function with robust predictive capacity to identify those patients with severe and progressive AKI. Future studies to validate these findings are warranted.
CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34
Authors: Yamane Fumihiro , Nishikawa Yumiko , Matsui Kazue , Asakura Miki , Iwasaki Eriko , Watanabe Koji , Tanimoto Hikaru , Sano Hiroki , Fujiwara Yuki , Stanley E Richard , Kanayama Naoki , Mabbott Neil A , Magari Masaki , Ohmori Hitoshi 
Published: September 2013

ABSTRACTWith the use of a mouse FDC line, FL-Y, we have been analyzing roles for FDCs in controlling B cell fate in GCs. Beside these regulatory functions, we fortuitously found that FL-Y cells induced a new type of CD11b+ monocytic cells (F4/80+, Gr-1−, Ly6C−, I-A/E−/lo, CD11c−, CD115+, CXCR4+, CCR2+, CX3CR1−) when cultured with a Lin−c-kit+ population from mouse spleen cells. The developed CD11b+ cells shared a similar gene-expression profile to mononuclear phagocytes and were designated as FDMCs. Here, we describe characteristic immunological functions and the induction mechanism of FDMCs. Proliferation of anti-CD40 antibody-stimulated B cells was markedly accelerated in the presence of FDMCs. In addition, the FDMC-activated B cells efficiently acquired GC B cell-associated markers (Fas and GL-7). We observed an increase of FDMC-like cells in mice after immunization. On the other hand, FL-Y cells were found to produce CSF-1 as well as IL-34, both of which are known to induce development of macrophages and monocytes by binding to the common receptor, CSF-1R, expressed on the progenitors. However, we show that FL-Y-derived IL-34, but not CSF-1, was selectively responsible for FDMC generation using neutralizing antibodies and RNAi. We also confirmed that FDMC generation was strictly dependent on CSF-1R. To our knowledge, a CSF-1R-mediated differentiation process that is intrinsically specific for IL-34 has not been reported. Our results provide new insights into understanding the diversity of IL-34 and CSF-1 signaling pathways through CSF-1R.
Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration
Authors: Maina Virginia , Marrella Veronica , Mantero Stefano , Cassani Barbara , Fontana Elena , Anselmo Achille , Del Prete Annalisa , Sozzani Silvano , Vezzoni Paolo , Poliani Pietro Luigi , Villa Anna 
Published: September 2013

ABSTRACTOS is a severe combined immunodeficiency characterized by erythrodermia and protracted diarrhea as a result of infiltration of oligoclonal-activated T cells, caused by hypomorphic mutations in RAGs. The RAG2R229Q mouse model fully recapitulates the clinical OS phenotype. We evaluated whether T and B cell defects, together with the abnormal lymphoid structure, could affect DC homeostasis and function. High density of LCs was observed in skin biopsies of Omenn patients and in the derma of RAG2R229Q mice, correlating with the presence of erythrodermia. In vivo models of cutaneous skin painting and CHS demonstrated a decreased migration of RAG2R229Q DCs—in particular, LCs—into draining LNs. Interestingly, at steady state, RAG2R229Q mice showed a reduction in DC number in all hematopoietic organs except LNs. Analysis of the MHCII marker revealed a diminished expression also upon the LPS-driven inflammatory condition. Despite the decreased number of peripheral DCs, BM pre-cDCs were present in normal number compared with RAG2+/+ controls, whereas pDCs and monocytes were reduced significantly. Overall, these results point to a secondary defect in the DC compartment, which contributes to clinical manifestations and autoimmunity in OS.
The pan-Bcl-2 blocker obatoclax promotes the expression of Puma, Noxa, and Bim mRNA and induces apoptosis in neoplastic mast cells
Authors: Peter Barbara , Cerny-Reiterer Sabine , Hadzijusufovic Emir , Schuch Karina , Stefanzl Gabriele , Eisenwort Gregor , Gleixner Karoline V , Hoermann Gregor , Mayerhofer Matthias , Kundi Michael , Baumgartner Sigrid , Sperr Wolfgang R , Pickl Winfried F , Willmann Michael , Valent Peter 
Published: September 2013

ABSTRACTAdvanced SM is an incurable neoplasm with short survival time. So far, no effective therapy is available for these patients. We and others have shown recently that neoplastic MC in ASM and MCL express antiapoptotic Mcl-1, Bcl-2, and Bcl-xL. In this study, we examined the effects of the pan-Bcl-2 family blocker obatoclax (GX015-070) on primary neoplastic MC, the human MC leukemia cell line HMC-1, and the canine mastocytoma cell line C2. Obatoclax was found to inhibit proliferation in primary human neoplastic MC (IC50: 0.057 μM), in HMC-1.2 cells expressing KIT D816V (IC50: 0.72 μM), and in HMC-1.1 cells lacking KIT D816V (IC50: 0.09 μM), as well as in C2 cells (IC50: 0.74 μM). The growth-inhibitory effects of obatoclax in HMC-1 cells were accompanied by an increase in expression of Puma, Noxa, and Bim mRNA, as well as by apoptosis, as evidenced by microscopy, TUNEL assay, and caspase cleavage. Viral-mediated overexpression of Mcl-1, Bcl-xL, or Bcl-2 in HMC-1 cells was found to introduce partial resistance against apoptosis-inducing effects of obatoclax. We were also able to show that obatoclax synergizes with several other antineoplastic drugs, including dasatinib, midostaurin, and bortezomib, in producing apoptosis and/or growth arrest in neoplastic MC. Together, obatoclax exerts major growth-inhibitory effects on neoplastic MC and potentiates the antineoplastic activity of other targeted drugs. Whether these drug effects can be translated to application in patients with advanced SM remains to be determined.
Supramolecular Chemistry of Pyrrole-Based π-Conjugated Molecules
Authors: Maeda Hiromitsu 
Published: September 2013

Abstract
This article summarizes the supramolecular chemistry of pyrrole-based π-conjugated molecules, with specific focus on the work carried out by the author’s group over the last nine years. The author provides a number of examples of supramolecular assemblies and functional materials comprising pyrrole-based molecules stabilized by noncovalent interactions such as metal coordination, hydrogen bonding, π–π stacking, and van der Waals forces. In particular, pyrrole-based π-conjugated molecules showed anion-binding behavior, and formed ion-based materials, wherein positively and negatively charged species were arranged in an ordered form by combination with appropriate cations.
Skeletal Reorganization of Enynes Catalyzed by a Ru(II)–Ru(III) Mixed-valence Complex under an Atmosphere of O2 or CO
Authors: Nakae Takahiro , Yasunaga Tomohiko , Kamiya Motonobu , Fukumoto Yoshiya , Chatani Naoto 
Published: September 2013

Abstract
A mixed-valence Ru(II)–Ru(III) complex was used to catalyze the skeletal reorganization of 1,6-enynes, leading to the production of 1-vinylcyclopentene derivatives. The reaction proceeded optimally in an atmosphere of O2 or CO. The presence of an alkyl group at the internal olefinic carbon in the starting enyne resulted in an increase in product yield compared to that bearing no substituent on the olefin moiety.
The Internet, News Consumption, and Political Attitudes – Evidence for Sweden
Authors: Liang Che-Yuan , Nordin Mattias 
Published: September 2013

Abstract
We investigate the effects of the rise of the Internet as an additional mass medium on news consumption patterns and political attitudes. We use Swedish survey data from 2002 to 2007, the period during which high-speed Internet (broadband) emerged. We find that broadband access is associated with online media consumption. The crowd out of offline consumption is, however, small. Furthermore, these altered news consumption patterns have no or small effects on political attitudes.
Combined treatment of green pitch pine wood by heat and superheated steam and the effects on physical properties of the products
Authors: Park Yonggun , Eom Chang-Deuk , Han Yeonjung , Park Jun-Ho , Chang Yoon-Seong , Yang Sang-Yun , Choi Joon-Weon , Yeo Hwanmyeong 
Published: September 2013

Abstract
Pitch pine (P. rigida) wood was treated with superheated steam (SHS) and the subsequent effects due to drying and heat treatment (HT) were observed. The following treatment parameters were tested: 180°C air HT, 220°C air HT, 0.1 MPa–180°C SHS HT, 0.1 MPa–220°C SHS HT, 0.5 MPa–180°C SHS HT, and 0.5 MPa–220°C SHS HT. No drying checks were observed in the specimens (500×150×50 mm3) treated at 0.5 MPa–220°C SHS and with these treatment parameters, equilibrium moisture content (EMC) was the lowest. Low EMC has an effect on physical properties such as shrinkage, compressive strength parallel to the grain, bending strength, hardness, and decay resistance. Based on the results, it is expected that the green wood in a large scale is possible to be simultaneously dried and heat-treated without occurrence of checks by the SHS HT process.
Mechanical performance of cellulose nanofibril film-wood flake laminate
Authors: Liu Jen-Chieh , Moon Robert J. , Rudie Alan , Youngblood Jeffrey P. 
Published: September 2013

Abstract
Homogeneous and transparent CNF films, fabricated from the (2,2,6,6- tetramethylpiperidin-1-yl) oxyl (TEMPO)-modified CNF suspension, were laminated onto wood flakes (WF) based on phenol-formaldehyde (PF) resin and the reinforcement potential of the material has been investigated. The focus was on the influence of CNF film lamination, relative humidity (RH), heat treatment, and anisotropic properties of WF on the CNF-WF laminate tensile properties (elastic modulus, ultimate tensile strength, strain to failure). Results demonstrated that CNF-WF laminates had improved mechanical performance as compared to the neat WF. In the WF transverse direction, there were gains of nearly 200% in Young’s modulus and 300% in ultimate tensile strength. However, in the WF axial direction, the reinforcement effect was minor after PF modification of the wood and the presence of the CNF layers. The effective elastic moduli of the CNF-WF laminates were calculated based on the laminated plate theory, and the calculation in both axial and transverse directions were in agreement with the experimental results.
Influence of Laboratory Mixing Procedures on Volumetric and Mechanical Properties of RAP Mixtures
Authors: Hajj Elie Y. , Souliman Mena I. , Sebaaly Peter E. , Barton Matthew 
Published: September 2013

Abstract
The primary goal of this study was to assess the effectiveness of specific laboratory mixing procedures in simulating the production of plant-produced hot mix asphalt (HMA) mixtures with high reclaimed asphalt pavement (RAP) content. Three distinct methods for incorporating the RAP material into the mixing process were examined. The first method consisted of heating and mixing the virgin aggregate, virgin asphalt binder, and RAP material at the appropriate mixing temperature for the virgin asphalt binder. The second method consisted of superheating the virgin aggregates according to the National Asphalt Pavement Association (NAPA) recommendations, with the virgin asphalt binder heated to the appropriate temperature and the RAP material introduced dry and at the ambient temperature. Last, the third method was similar to the second procedure with the exception of adding the RAP material wet at the ambient temperature. Mixing temperatures were examined over the duration of the mixing process for each method. This provided insight into how effectively the virgin aggregate is transferring heat to the RAP material. Additionally, a short-term oven-aging analysis was utilized to determine the appropriate aging time in the laboratory to replicate the aging experienced by the plant-produced mixtures. Last, compacted samples were created for each mixing method, as well as for the plant-produced laboratory-compacted mixtures, to analyze the volumetric properties and mechanical properties using the dynamic modulus. Based on the data generated in this study, the most appropriate method was recommended to be instituted in the laboratory for mixing HMA mixtures containing RAP material because of its simplicity and its close results to the plant-produced mixtures.
Are prognostic scoring systems of value in patients with follicular thyroid carcinoma?
Authors: Ríos A , Rodríguez J M , Ferri B , Matínez-Barba E , Febrero B , Parrilla P 
Published: September 2013

PurposeMost prognostic systems for differentiated carcinoma have been designed for papillary carcinoma.ObjectiveTo analyze the value of the existing prognostic systems for evaluating follicular carcinoma and to determine whether any of them have a better predictive effect.MethodsA total of 66 follicular carcinomas were analyzed. The following prognostic systems were studied: EORTC, AGES, AMES, MACIS, TNM, and NTCTCS.ResultsThe AGES and AMES systems did not demonstrate a good prognostic correlation. In the EORTC system, the rate of disease-free patients was 89% in group 1, 75% in group 2, 69% in group 3, and 0% in group 4. The MACIS system showed 83, 60, 67, and 0% of disease-free patients respectively. The TNM system showed 81, 71, 50, and 0% of disease-free patients respectively. Finally, the NTCTCS system demonstrated 100, 84, 53, and 0% of disease-free patients respectively. Cox's regression analysis was used to calculate the proportion of variation in survival time explained (PVE). The prognostic classification system with the greatest survival prediction was EORTC at 67.64% of PVE, followed by TNM at 62.5% of PVE, and MACIS at 57.82% of PVE.ConclusionsMACIS and TNM are good prognostic systems for evaluating follicular thyroid carcinoma, although the one with the most prognostic value was the EORTC system.