bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal of standardized guidelines for the production and quality control of autologous serum eye drops in Korea: based on a nationwide survey
Authors: Lee Hye Ryun , Hong Yun Ji , Chung Soie , Hwang Sang Mee , Kim Taek Soo , Song Eun Young , Park Kyoung Un , Song Junghan , Han Kyou Sup 
Published: March 2014

BackgroundAutologous serum eye drops (ASEDs) have been used to treat many eye diseases. However, there are no standardized guidelines for the production and quality control (QC) of ASEDs in Korea. Our aim was to propose standardized guidelines for the production and QC of ASEDs.Study Design and MethodsWe conducted a nationwide survey consisting of questions regarding the methods used in each hospital for the production and QC of ASEDs. The survey was sent by e‐mail to 89 doctors responsible for the blood banks at different hospitals.ResultsThirty‐two hospitals replied, and 13 hospitals reported using the ASEDs in the treatment of patients with eye diseases. The screening test for patients, amount of blood sampling, type of bottle used for blood collection, details about the production of the eye drops, and storage methods and shelf life of unopened and opened bottles of eye drops varied between hospitals.ConclusionBased on an analysis of the survey results and a review of the standard operating procedures and protocols for ASEDs used in Japan, Germany, England and Wales, and the United States, we proposed standardized guidelines for the production and QC of ASEDs in Korea. ASEDs are not cell therapy products in the strictest sense. However, because eye drops are composed of serum isolated from blood and are used in patients, we consider ASEDs to be the basis for cell therapy products. Therefore, ASEDs should be produced and stored according to standardized guidelines based on the Good Manufacturing Practice guidelines.
Effect of Defect on Elastic/Plastic and Creep Behavior of Bone: A Finite Element Study
Authors: Ajdari A. , Canavan P. K. , Nayeb-Hashemi H. , Warner G. 
Published: March 2014

Three-dimensional structure of trabecular bone can be modeled by 2D or 3D Voronoi structure. The effect of missing cell walls on the mechanical properties of 2D honeycombs is a first step towards understanding the effect of local bone resorption due to osteoporosis. In patients with osteoporosis, bone mass is lost first by thinning and then by resorption of the trabeculae [1].
Furthermore, creep response is important to analyze in cellular solids when the temperature is high relative to the melting temperature. For trabecular bone, as body temperature (38 °C) is close to the denaturation temperature of collagen (52 °C), trabecular bone creeps [1]. Over the half of the osteoporotic vertebral fractures that occur in the elderly, are the result of the creep and fatigue loading associated with the activities of daily living [2].
The objective of this work is to understand the effect of missing walls and filled cells on elastic-plastic behavior of both regular hexagonal and non-periodic Voronoi structures using finite element analysis.
The results show that the missing walls have a significant effect on overall elastic properties of the cellular structure. For both regular hexagonal and Voronoi materials, the yield strength of the structure decreased by more than 60% by introducing 10% missing walls. In contrast, the results indicate that filled cells have much less effect on the mechanical properties of both regular hexagonal and Voronoi materials.
Stride Rate and Walking Intensity in Healthy Older Adults
Authors: Peacock Leslie , Hewitt Allan , Rowe David A. , Sutherland Rona 
Published: March 2014

Purpose:The study investigated (a) walking intensity (stride rate and energy expenditure) under three speed instructions; (b) associations between stride rate, age, height, and walking intensity; and (c) synchronization between stride rate and music tempo during overground walking in a population of healthy older adults.Methods:Twenty-nine participants completed 3 treadmill-walking trials and 3 overground-walking trials at 3 self-selected speeds. Treadmill VO2 was measured using indirect calorimetry. Stride rate and music tempo were recorded during overground-walking trials.Results:Mean stride rate exceeded minimum thresholds for moderate to vigorous physical activity (MVPA) under slow (111.41 ± 11.93), medium (118.17 ± 11.43), and fast (123.79 ± 11.61) instructions. A multilevel model showed that stride rate, age, and height have a significant effect (p < .01) on walking intensity.Conclusions:Healthy older adults achieve MVPA with stride rates that fall below published minima for MVPA. Stride rate, age, and height are significant predictors of energy expenditure in this population. Music can be a useful way to guide walking cadence.
Improvement of Outcomes With Nonconcurrent Strength and Cardiovascular-Endurance Rehabilitation Conditioning After ACI Surgery to the Knee
Authors: Bailey Andrea Kay , Minshull Claire , Richardson James , Gleeson Nigel P. 
Published: March 2014

Context:Autologous chondrocyte implantation (ACI) aims to restore hyaline cartilage. Traditionally, ACI rehabilitation is prescribed in a concurrent (CON) format. However, it is well known from studies in asymptomatic populations that CON training produces an interference effect that can attenuate strength gains. Strength is integral to joint function, so adopting a nonconcurrent (N-CON) approach to ACI rehabilitation might improve outcomes.Objective:To assess changes in function and neuromuscular performance during 48 wk of CON and N-CON physical rehabilitation after ACI to the knee.Setting:Orthopedic Hospital NHS Foundation Trust.Design:Randomized control, pilot study.Participants:11 patients (9 male, 2 female; age 32.3 ± 6.6 y; body mass 79.3 ±10.4 kg; time from injury to surgery 7.1 ± 4.9 mo [mean ± SD]) randomly allocated to N-CON:CON (2:1).Interventions:Standardized CON and N-CON physiotherapy that involved separation of strength and cardiovascular-endurance conditioning.Main Outcome Measures:Function in the single-leg-hop test, patient-reported outcomes (Knee injury and Osteoarthritis Outcome Score [KOOS], International Knee Documentation Committee subjective questionnaire [IKDC]), and neuromuscular outcomes of peak force (PF), rate of force development (RFD), electromechanical delay (EMD), and sensorimotor performance (force error [FE]) of the knee extensors and flexors of the injured and noninjured legs, measured presurgery and at 6, 12, 24, and 48 wk postsurgery.Results:Factorial ANOVAs with repeated measures of group by leg and by test occasion revealed significantly superior improvements for KOOS, IKDC, PF, EMD, and FE associated with N-CON vs CON rehabilitation (F1.5,13.4 GG = 3.7−4.7, P < .05). These results confirm increased peak effectiveness of N-CON rehabilitation (~4.5−13.3% better than CON over 48 wk of rehabilitation). N-CON and CON showed similar patterns of improvement for single-leg-hop test and RFD.Conclusions:Nonconcurrent strength and cardiovascular-endurance conditioning during 48 wk of rehabilitation after ACI surgery elicited significantly greater improvements to functional and neuromuscular outcomes than did contemporary concurrent rehabilitation.
Virus-Induced Transcriptional Changes in the Brain Include the Differential Expression of Genes Associated with Interferon, Apoptosis, Interleukin 17 Receptor A, and Glutamate Signaling as Well as Flavivirus-Specific Upregulation of tRNA Synthetases
Authors: Clarke Penny , Leser J. Smith , Bowen Richard A. , Tyler Kenneth L. 
Published: March 2014

ABSTRACTFlaviviruses, particularly Japanese encephalitis virus (JEV) and West Nile virus (WNV), are important causes of virus-induced central nervous system (CNS) disease in humans. We used microarray analysis to identify cellular genes that are differentially regulated following infection of the brain with JEV (P3) or WNV (New York 99). Gene expression data for these flaviviruses were compared to those obtained following infection of the brain with reovirus (type 3 Dearing), an unrelated neurotropic virus. We found that a large number of genes were up-regulated by all three viruses (using the criteria of a change of >2-fold and aPvalue of <0.001), including genes associated with interferon signaling, the immune system, inflammation, and cell death/survival signaling. In addition, genes associated with glutamate signaling were down-regulated in infections with all three viruses (criteria, a >2-fold change and aPvalue of <0.001). These genes may serve as broad-spectrum therapeutic targets for virus-induced CNS disease. A distinct set of genes were up-regulated following flavivirus infection but not following infection with reovirus. These genes were associated with tRNA charging and may serve as therapeutic targets for flavivirus-induced CNS disease.IMPORTANCEViral infections of the central nervous system (CNS) are an important cause of morbidity and mortality. Treatment options for virus-induced CNS disease are limited, and for many clinically important neurotropic viruses, no specific therapy of proven benefit is currently available. We performed microarray analysis to identify genes that are differentially regulated in the brain following virus infection in order to identify pathways that might provide novel therapeutic targets for virus-induced CNS disease. Although several studies have described gene expression changes following virus infection of the brain, this report is the first to directly compare large-scale gene expression data from different viruses. We identified genes that are differentially regulated in infection of the brain with viruses from different families and those which appear to be specific to flavivirus infections.
Occupational noise exposure and noise-induced hearing loss are associated with work-related injuries leading to admission to hospital
Authors: Girard Serge-André , Leroux Tony , Courteau Marilene , Picard Michel , Turcotte Fernand , Richer Olivier 
Published: March 2014

ObjectiveThis study focuses on work-related injuries that required admission to hospital in a population of male workers exposed to occupational noise (≥80 dBA) which some displayed a hearing loss due to their exposure.MethodsThe study population count 46 550 male workers, 1670 (3.6%) of whom incurred at least one work-related injury requiring admission to hospital within a period of 5 years following hearing tests conducted between 1987 and 2005. The noise exposure and hearing loss-related data were gathered during occupational noise-induced hearing loss (NIHL) screening. The hospital data were used to identify all members of the study population who were admitted, and the reason for admission. Finally, access to the death-related data made it possible to identify participants who died during the course of the study. Cox proportional hazards model taking into account hearing status, noise levels, age and cumulative duration of noise exposure at the time of the hearing test established the risk of work-related injuries leading to admission to hospital.ResultsFor each dB of hearing loss, a statistically significant risk increase was observed (HR=1.01 dB 95% CI 1.006 to 1.01). An association (HR=2.36 95% CI 2.01 to 2.77) was also found between working in an occupational ambient noise ≥100 dBA and the risk of injury.ConclusionsFrom a safety perspective, this issue is highly relevant; especially when workers are exposed to intense ambient noise and NIHL.
Relative and Tate homology with respect to semidualizing modules
Authors: Di Zhenxing , Zhang Xiaoxiang , Liu Zhongkui , Chen Jianlong 
Published: March 2014

We introduce and investigate in this paper a kind of Tate homology of modules over a commutative coherent ring based on Tate ℱC-resolutions, where C is a semidualizing module. We show firstly that the class of modules admitting a Tate ℱC-resolution is equal to the class of modules of finite 𝒢(ℱC)-projective dimension. Then an Avramov–Martsinkovsky type exact sequence is constructed to connect such Tate homology functors and relative homology functors. Finally, motivated by the idea of Sather–Wagstaff et al. [Comparison of relative cohomology theories with respect to semidualizing modules, Math. Z. 264 (2010) 571–600], we establish a balance result for such Tate homology over a Cohen–Macaulay ring with a dualizing module by using a good conclusion provided in [E. E. Enochs, S. E. Estrada and A. C. Iacob, Balance with unbounded complexes, Bull. London Math. Soc. 44 (2012) 439–442].
Trace transitioning and exception handling in a trace-based JIT compiler for java
Authors: Häubl Christian , Wimmer Christian , Mössenböck Hanspeter 
Published: March 2014

Trace-based Just-In-Time (JIT) compilation generates machine code for frequently executed paths (so-called traces) instead of whole methods. While this has several advantages, it complicates invocation of compiled traces as well as exception handling, so that previous trace-based compilers limited the way in which traces could be invoked.
We present a significantly enhanced trace-based compiler where arbitrary transitions between interpreted and compiled traces are possible. For that, we introduce suitable trace calling conventions and extend exception handling to work both within traces and across trace boundaries. Furthermore, we use the recorded trace information for optimizations and combine the tracing ideas with ideas from partial-method compilation to avoid code bloat.
An extensive evaluation with the benchmark suites DaCapo 9.12 Bach and SPECjvm2008 shows that our trace-based compiler achieves up to 59% higher peak performance than the method-based Java HotSpot client compiler. On a few benchmarks, our fairly simple trace-based compiler shows a higher peak performance than the Java HotSpot server compiler, which is one of today's best optimizing JIT compilers for Java.
Uptake of Genetic Testing and Pre‐Test Levels of Mental Distress in Norwegian Families with Known BRCA1 Mutations
Authors: Reichelt Jon G. , Dahl Alv A. , Heimdal Ketil , Møller Pål 
Published: March 2014

232 family members from 27 Norwegian families with BRCAl mutations were offered genetic testing. 180/232 (78%) chose to be tested, 14/232 (6%) have not yet decided and 38/232 (16%) declined. All 232 persons were invited to fill in the following questionnaires when offered testing: Impact of Event Scale (IES), Hospital Anxiety and Depression Scale (HADS), General Health Questionnaire (GHQ‐28) and Beck Hopelessness Scale (BHS). 207/232 (89%) responded to the questionnaires. Of those declining to be tested 23/38 (61%) answered the questionnaires compared to 170/180 (94%) of those wanting the test (p < 0.0001).A higher proportion of females with a history of cancer than females without such a history had abnormal scores on the IES‐intrusion and GHQ questionnaires (p < 0.001). Healthy females who were deciding on predictive testing had the same or lower prevalence of mental distress compared to the general population, between 4.3% and 18.0% as measured by the different questionnaires. Males did not differ from healthy females on any of the measures.According to their HADS scores, women without a history of cancer deciding on predictive testing for breast‐ovarian cancer had lower or equal levels of mental distress compared to the general population. The high uptake of genetic testing combined with the lower than normal prevalence of mental distress indicates that the activity may continue as practised, awaiting longitudinal data concerning the levels of mental distress after genetic testing.
COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis
Authors: Gallouet Anne-Sophie , Travert Marion , Bresson-Bepoldin Laurence , Guilloton Fabien , Pangault Céline , Caulet-Maugendre Sylvie , Lamy Thierry , Tarte Karin , Guillaudeux Thierry 
Published: March 2014

AbstractPurpose: Despite therapeutic advances, non–Hodgkin lymphomas (NHL) remain incurable. They form a group of neoplasms strongly dependent on their inflammatory microenvironment, which plays an important supportive role in tumor B-cell survival and in the resistance to antitumor immune response. New therapies must consider both tumor cells and their surrounding microenvironmentExperimental Design: Stromal cells, derived from bone marrow or lymph nodes, and B cells from follicular lymphoma patients were cocultured or cultured alone with celecoxib treatment, a nonsteroidal anti-inflammatory drug, and/or TRAIL, a promising cytotoxic molecule for cancer therapy.Results: In this study, we show that follicular lymphoma stromal cells produce large amounts of PGE2. This production is abrogated after celecoxib treatment, targeting the COX-2 isoenzyme involved in PGE2 synthesis. Furthermore, we demonstrate that celecoxib increases apoptosis in NHL B-cell lines and in primary follicular lymphoma B cells cocultured with stromal cells, but independently of the PGE2/COX-2 axis. Finally, celecoxib increases the apoptotic activity of TRAIL. We provide evidence that celecoxib affects proliferation and sensitizes NHL B-cell lines to apoptosis through COX-2–independent effects by slowing down the cell cycle and decreasing the expression of survival proteins, such as Mcl-1.Conclusions: These data suggest new potent strategies for NHL therapy combining drugs targeting both tumor B cells and survival signals provided by the tumor microenvironment. Clin Cancer Res; 20(10); 2663–73. ©2014 AACR.
Using Varied Microphysics to Account for Uncertainty in Warm-Season QPF in a Convection-Allowing Ensemble
Authors: Duda Jeffrey D. , Wang Xuguang , Kong Fanyou , Xue Ming 
Published: March 2014

Abstract
Two approaches for accounting for errors in quantitative precipitation forecasts (QPFs) due to uncertainty in the microphysics (MP) parameterization in a convection-allowing ensemble are examined. They include mixed MP (MMP) composed mostly of double-moment schemes and perturbing parameters within the Weather Research and Forecasting single-moment 6-class microphysics scheme (WSM6) MP scheme (PPMP). Thirty-five cases of real-time storm-scale ensemble forecasts produced by the Center for Analysis and Prediction of Storms during the NOAA Hazardous Weather Testbed 2011 Spring Experiment were examined.
The MMP ensemble had better fractions Brier scores (FBSs) for most lead times and thresholds, but the PPMP ensemble had better relative operating characteristic (ROC) scores for higher precipitation thresholds. The pooled ensemble formed by randomly drawing five members from the MMP and PPMP ensembles was no more skillful than the more accurate of the MMP and PPMP ensembles. Significant positive impact was found when the two were combined to form a larger ensemble.
The QPF and the systematic behaviors of derived microphysical variables were also examined. The skill of the QPF among different members depended on the thresholds, verification metrics, and forecast lead times. The profiles of microphysics variables from the double-moment schemes contained more variation in the vertical than those from the single-moment members. Among the double-moment schemes, WDM6 produced the smallest raindrops and very large number concentrations. Among the PPMP members, the behaviors were found to be consistent with the prescribed intercept parameters. The perturbed intercept parameters used in the PPMP ensemble fell within the range of values retrieved from the double-moment schemes.
Transoral Robotic Surgery and the Unknown Primary: A Cost‐Effectiveness Analysis
Authors: Byrd J. Kenneth , Smith Kenneth J. , de Almeida John R. , Albergotti W. Greer , Davis Kara S. , Kim Seungwon W. , Johnson Jonas T. , Ferris Robert L. , Duvvuri Umamaheswar 
Published: March 2014

ObjectiveTo evaluate the cost‐effectiveness of transoral robotic surgery (TORS) for the diagnosis and treatment of cervical unknown primary squamous cell carcinoma (CUP).Study DesignCase series with chart review.SettingTertiary academic hospital.Subjects and MethodsA retrospective chart review was performed on patients with new occult primary squamous cell carcinoma of the head and neck with nondiagnostic imaging and/or endoscopy who were treated with TORS at a tertiary hospital between 2009 and 2012. Direct costs were obtained from the hospital's billing system, and national data were used for inpatient hospital costs and physician fees. The proportion of tumors found in 3 strategies was used as effectiveness to calculate the incremental cost‐effectiveness ratio.ResultsIn total, 206 head and neck robotic cases were performed at our institution between December 2009 and December 2012. Three surgeons performed TORS on 22 patients for occult primary squamous cell carcinoma. The primary tumor was located in 19 of 22 patients (86.4%). The incremental cost‐effectiveness ratio for sequential and simultaneous examination under anesthesia with tonsillectomy (EUA) and TORS base of tongue resection was $8619 and $5774 per additional primary identified, respectively.ConclusionSequential EUA followed by TORS is associated with an incremental cost‐effectiveness ratio of $8619 compared with traditional EUA alone. Bilateral base of tongue resection should be considered in the workup of these patients, particularly if the palatine tonsils have already been removed.
Fear for external cephalic version and depression: predictors of successful external cephalic version for breech presentation at term?
Authors: Ciliacus Emily , van der Zalm Marieke , Truijens Sophie E , Hasaart Tom H , Pop Victor J , Kuppens Simone M 
Published: March 2014

Abstract

Background
Objective was to determine whether fear for external cephalic version (ECV) and depression are associated with the success rate of ECV in women with a breech presentation at term.

Methods
Prospective study conducted in the Catharina Hospital Eindhoven between October 2007 and May 2012. Participants fulfilled The Edinburgh Depression Scale (EDS) questionnaire and expressed their degree of fear on a visual analogue scale from one to ten before ECV. Obstetric factors were evaluated as well. Primary outcome was the relation between psychological factors (fear for ECV and depression EDS scores) and ECV success rate. Secondary outcome was a possible relation between fear for ECV and increased abdominal muscle tension.

Results
The overall success rate was 55% and was significantly lower (p < 0.001) in nulliparous women (44.3%) compared with parous women (78.0%). Fear for ECV and depression EDS-scores were not related with ECV success rate. Parity, placental location, BMI and engagement of the fetal breech were obstetric factors associated with ECV outcome. There was no relation between fear for ECV and abdominal muscle tone.

Conclusion
Fear for ECV and depression were not related with ECV success rate in this study. Engagement of the fetal breech was the most important factor associated with a successful ECV.

Trial registration
EBIS: The Eindhoven Breech Intervention Study, NCT00516555.