bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Hispanic Ethnicity on Knowledge and Behavior Among Patients With Diabetes
Authors: Bhargava Amit , Wartak Siddharth A. , Friderici Jennifer , Rothberg Michael B. 
Published: February 2014

Purpose The purpose of the study was to measure the current level of awareness of the American Heart Association’s 7 risk/protective factors of cardiovascular health among adults with diabetes of Hispanic and non-Hispanic origin and to identify factors associated with knowledge deficits. Methods A cross-sectional survey measured demographic data, personal behaviors/health factors, cardiovascular disease (CVD) history, and knowledge of 7 components of ideal cardiovascular health (smoking, obesity, exercise, diet, cholesterol, blood pressure, and blood glucose). A subset of 331 Hispanic and white patients with diabetes was surveyed. Knowledge scores were dichotomized between full knowledge (7 components) and less than full knowledge and compared between ethnicities using multiple logistic regression. Results Seventy-nine percent of surveys were returned; 50.5% of subjects were Hispanic. Median age was 64.5 years with 60.7% being female. Two-thirds of the sample completed high school and 26% reported comorbid CVD. Recognition of diabetes as a risk factor didn’t differ by ethnicity. Thirty-five percent of respondents identified 7 American Heart Association risk factors. Hispanics were less likely to identify 7 components. After adjustment for education and English literacy, the difference disappeared. Better knowledge was positively associated with healthier behaviors for high cholesterol, hypertension, and exercise only among white patients. Conclusions Hispanic patients with diabetes exhibit less knowledge about CVD risk/protective factors due to lower education and English literacy. Educational interventions should be tailored to those with less education/limited English proficiency.
Intensive, progressive exercise improves quality of life following lumbar microdiskectomy: a randomized controlled trial
Authors: Beneck George J , Popovich John M , Selkowitz David M , Azen Stan , Kulig Kornelia ,   on behalf of Physical Therapy Clinical Research Network (PTClinResNet)
Published: February 2014

Objective: The purpose of the study was to examine changes in quality of life measures in patients who have undergone an intensive exercise program following a single level microdiskectomy. Design: Randomized controlled trial with blinded examiners. Setting: The study was conducted in outpatient physical therapy clinics. Subjects: Ninety-eight participants (53 male, 45 female) who had undergone a single-level lumbar microdiskectomy allocated to receive exercise and education or education only. Interventions: A 12-week periodized exercise program of lumbar extensor strength and endurance training, and mat and upright therapeutic exercises was administered. Outcome measures: Quality of life was tested with the Short Form 36 (SF-36). Measurements were taken 4–6 weeks postsurgery and following completion of the 12-week intervention program. Since some participants selected physical therapy apart from the study, analyses were performed for both an as-randomized (two-group) design and an as-treated (three-group) design. Results: In the two-group analyses, exercise and education resulted in a greater increase in SF-36 scales, role physical (17.8 vs. 12.1) and bodily pain (13.4 vs. 8.4), and the physical component summary (13.2 vs. 8.9). In the three-group analyses, post-hoc comparisons showed exercise and education resulted in a greater increase in the SF-36 scales, physical function (10.4 vs. 5.6) and bodily pain (13.7 vs. 8.2), and the physical component summary (13.7 vs. 8.9) when compared with usual physical therapy. Conclusions: An intensive, progressive exercise program combined with education increases quality of life in patients who have recently undergone lumbar microdiskectomy.
Susceptibility-weighted imaging for stem cell visualization in a rat photothrombotic cerebral infarction model
Authors: Ha Bon Chul , Jung Jisung , Kwak Byung Kook 
Published: February 2014

Background In cell therapy, magnetic resonance imaging (MRI) has been used to visualize superparamagnetic iron oxide (SPIO)-labeled stem cells homing to a lesion. Improving traceability is to utilize the sequence that maximizes sensitivity to the susceptibility effect of SPIO. Purpose To explore the best method by comparing the MRI sequences to visualize mesenchymal stem cells (MSCs) labeled with SPIO. Material and Methods Human bone marrow (hBM)-derived MSCs were labeled by internalization of SPIO nanoparticles. In vitro MRI was performed for the SPIO-labeled hBM-MSCs in tubes with T2-weighted (T2W), T2*-weighted (T2*W), and susceptibility-weighted images (SWI). Contrast-to-noise ratio (CNR) and volumes of dark signal of SPIO-labeled hBM-MSCs were obtained on images of each sequence. Photothrombotic cerebral infarction (PTCI) was induced in eight rats, and 2.5 × 105 SPIO-labeled hBM-MSCs were infused through the tail vein on the third day. In vivo MRI of the rat brain was performed using a 3.0 T MRI on the first, third, seventh, and 14th days. CNRspio was obtained on T2W imaging, T2*W imaging, and SWI. The dark signals were compared with the SPIO-positive cells of Prussian blue staining. Results In vitro MRI of 5 × 105 SPIO-labeled hBM-MSCs showed the CNR and volume of dark signal to be 63, 517 mm3 in SWI, 41, 228 mm3 in T2*W imaging, and 56, 41 mm3 in T2W imaging, respectively. In vivo MRI showed a dark signal surrounding the high signal intensity of PTCI. Pathologically, the dark signals were matched with SPIO-labeled hBM-MSC in the corresponding rat. The dark signal was most prominent in SWI, then T2*W imaging, and finally in T2W imaging ( P <0.05). In SWI, other causes of dark signals were matched with the veins and the choroid plexuses on histopathology. Conclusion SWI can visualize SPIO-labeled hBM-MSCs more sensitively, earlier, and with larger size and greater contrast than T2W imaging and T2*W imaging.
The value of inflammatory parameters in the prognosis of malignant mesothelioma
Authors: Abakay Ozlem , Tanrikulu Abdullah Cetin , Palanci Yilmaz , Abakay Abdurrahman 
Published: February 2014

Objective This study investigated the relationship between potential prognostic parameters that may be associated with increased inflammation and survival in patients with malignant mesothelioma (MM). Methods This retrospective study assessed potential prognostic parameters measured at the time of MM diagnosis. Data on asbestos exposure, histopathological subtype of MM and laboratory parameters were collected. Results In 155 patients with MM (90 male), mean survival time was 13.9 months. In univariate analysis, age ≥60 years and neutrophil-to-lymphocyte ratio (NLR) ≥3 were associated with significantly shortened median survival times. In multivariate analysis, nonepithelial subtype, red cell distribution width (RDW) ≥20% and NLR ≥3 were associated with significantly shortened median survival times. Mortality rate was increased 2.77-, 1.67- and 1.52-fold in patients with RDW ≥20%, NLR ≥3 and nonepithelial subtype, respectively. Nonepithelial subtype, white blood cell count ≥11 200 µl and platelet-to-lymphocyte ratio ≥300 at baseline were associated with a heightened NLR value. Conclusions The NLR and RDW were significant predictive factors for MM prognosis.
Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial
Authors: Kim Yun-Hee , Namgung Jin , Lim Choon-Hak 
Published: February 2014

Objectives To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine. Methods Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30 s, followed by propofol (0.5 mg/kg). Pain was evaluated using a four-point scale. Results The incidence and severity of pain was significantly lower in the lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg cisatracurium groups (n = 50/group). There was no significant difference between the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity of pain. Conclusions 0.15 mg/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications.
Combined visual and motor evoked potentials predict multiple sclerosis disability after 20 years
Authors: Schlaeger Regina , Schindler Christian , Grize Leticia , Dellas Sophie , Radue Ernst W , Kappos Ludwig , Fuhr Peter 
Published: February 2014

Background: The development of predictors of multiple sclerosis (MS) disability is difficult due to the complex interplay of pathophysiological and adaptive processes. Objective: The purpose of this study was to investigate whether combined evoked potential (EP)-measures allow prediction of MS disability after 20 years. Methods: We examined 28 patients with clinically definite MS according to Poser’s criteria with Expanded Disability Status Scale (EDSS) scores, combined visual and motor EPs at entry (T0), 6 (T1), 12 (T2) and 24 (T3) months, and a cranial magnetic resonance imaging (MRI) scan at T0 and T2. EDSS testing was repeated at year 14 (T4) and year 20 (T5). Spearman rank correlation was used. We performed a multivariable regression analysis to examine predictive relationships of the sum of z-transformed EP latencies ( s-EPT0) and other baseline variables with EDSST5. Results: We found that s-EPT0 correlated with EDSST5 (rho=0.72, p<0.0001) and ΔEDSST5-T0 (rho=0.50, p=0.006). Backward selection resulted in the prediction model: E (EDSST5)=3.91–2.22×therapy+0.079×age+0.057× s-EPT0 (Model 1, R2=0.58) with therapy as binary variable (1=any disease-modifying therapy between T3 and T5, 0=no therapy). Neither EDSST0 nor T2-lesion or gadolinium (Gd)-enhancing lesion quantities at T0 improved prediction of EDSST5. The area under the receiver operating characteristic (ROC) curve was 0.89 for model 1. Conclusions: These results further support a role for combined EP-measures as predictors of long-term disability in MS.
The Plantar Plate of the First Metatarsophalangeal Joint
Authors: Lucas Douglas E. , Philbin Terrence , Hatic Safet 
Published: February 2014

The plantar plate of the first metatarsophalangeal (MP) joint is a critical structure of the forefoot that has been identified as a major stabilizer within the capsuloligamentous complex. Many studies have clarified and documented the anatomy of the lesser toe MP plantar plates, but few have looked closely at the anatomy of the first MP joint. Ten cadaveric specimens were examined to identify and document the objective anatomic relationship of the plantar plate, tibial sesamoid, and surrounding osseus structures. The average distance of the plantar plate distal insertion from the joint line into the proximal phalanx was 0.33 mm. The plantar plate was inserted into the metatarsal head on average 17.29 mm proximal from the joint line. The proximal aspect of the sesamoid was 18.55 mm proximal to the distal attachment of the plantar plate to the phalanx. The distal aspect of the sesamoid averaged 4.69 mm away from the distal attachment into the proximal phalanx. The footprint of the distal plate insertion was on average 6.33 mm in length in the sagittal plane. The authors hope that these objective data measures can aid in the understanding and subsequent surgical repair of this important forefoot structure. Level of Evidence: Level V: Cadaver study
Return to Play After Open Bankart Repair
Authors: Stone Geoffrey P. , Pearsall Albert W. 
Published: February 2014

Background: Results of open Bankart repair have been well reported. However, less information is available outlining the timetable for return to play (RTP) in athletes after this procedure. Purpose: To review the current literature regarding (1) the timetable recommended for athletes to RTP after an open Bankart repair and (2) the objective criteria on which the decision to allow an athlete to RTP is based. Study Design: Systematic review; Level of evidence, 4. Methods: A comprehensive literature search was conducted of all relevant English-language articles using the electronic databases OVID and PubMed between the years 1947 and 2012 to identify open Bankart repair. Two reviewers screened articles for eligibility based on the following criteria: (1) an open Bankart repair, (2) a minimum follow-up of at least 8 months, (3) any report that described the procedure in athletes, and (4) any report that described the time for an athlete to RTP. All relevant data were collected and analyzed with regard to number of patients; mean follow-up; Rowe, Constant, and American Shoulder and Elbow (ASES) scores; redislocation rate; and return-to-sport timing. Results: In all, 559 relevant citations were identified, of which 29 articles met the inclusion criteria. The mean follow-up was 51.7 months (range, 8-162 months), and the mean age was 25.9 years (range, 21-31 years). The average Rowe score for all studies was 86.9 (range, 63-90). The average redislocation rate was 5.3%. Twenty-six of 29 studies cited a specific timetable for unrestricted RTP, with an average of 23.2 weeks (range, 12-36 weeks). Only 38% of authors reported sport-specific criteria for return to competition, with the majority allowing return to noncontact sports at 12 to 16 weeks, and the resumption of throwing/contact sports by 24 weeks. Three reports described specific functional parameters for RTP. Conclusion: The current review summarized return-to-play guidelines for athletic competition after open Bankart repair. These data may provide general guidelines to aid surgeons when determining the appropriate timetable to allow an athlete to return to unrestricted competition.
NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML
Authors: Adamia Sophia , Bar-Natan Michal , Haibe-Kains Benjamin , Pilarski Patrick M. , Bach Christian , Pevzner Samuel , Calimeri Teresa , Avet-Loiseau Herve , Lode Laurence , Verselis Sigitas , Fox Edward A. , Galinsky Ilene , Mathews Steven , Dagogo-Jack Ibiayi , Wadleigh Martha , Steensma David P. , Motyckova Gabriela , Deangelo Daniel J. , Quackenbush John , Tenen Daniel G. , Stone Richard M. , Griffin James D. 
Published: February 2014

Key PointsOverall, our results suggest that NOTCH2 and FLT3 aberrant splicing is a common event in AML that correlates with disease status and may correlate with disease outcomes. Selected variants of NOTCH2 and FLT3 transcripts were detected in a significant number of AML patients and could be useful as disease markers.
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells
Authors: Kobayashi Chiharu I. , Takubo Keiyo , Kobayashi Hiroshi , Nakamura-Ishizu Ayako , Honda Hiroaki , Kataoka Keisuke , Kumano Keiki , Akiyama Hideo , Sudo Tetsuo , Kurokawa Mineo , Suda Toshio 
Published: February 2014

Key PointsCD25+ CML LICs have high LIC capacity and secrete cytokines that constitute the LIC niche. Targeting the IL-2/CD25 axis effectively eliminates CML LICs and improves the survival of CML model mice.
Diffusible signal factor (DSF) quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens
Authors: Deng Yinyue , Lim Amy , Lee Jasmine , Chen Shaohua , An Shuwen , Dong Yi-Hu , Zhang Lian-Hui 
Published: February 2014

Abstract

Background
Extensive use of antibiotics has fostered the emergence of superbugs that are resistant to multidrugs, which becomes a great healthcare and public concern. Previous studies showed that quorum sensing signal DSF (diffusible signal factor) not only modulates bacterial antibiotic resistance through intraspecies signaling, but also affects bacterial antibiotic tolerance through interspecies communication. These findings motivate us to exploit the possibility of using DSF and its structurally related molecules as adjuvants to influence antibiotic susceptibility of bacterial pathogens.

Results
In this study, we have demonstrated that DSF signal and its structurally related molecules could be used to induce bacterial antibiotic susceptibility. Exogenous addition of DSF signal (cis-11-methyl-2-dodecenoic acid) and its structural analogues could significantly increase the antibiotic susceptibility of Bacillus cereus, possibly through reducing drug-resistant activity, biofilm formation and bacterial fitness. The synergistic effect of DSF and its structurally related molecules with antibiotics on B. cereus is dosage-dependent. Combination of DSF with gentamicin showed an obviously synergistic effect on B. cereus pathogenicity in an in vitro model. We also found that DSF could increase the antibiotic susceptibility of other bacterial species, including Bacillus thuringiensis, Staphylococcus aureus, Mycobacterium smegmatis, Neisseria subflava and Pseudomonas aeruginosa.

Conclusion
The results indicate a promising potential of using DSF and its structurally related molecules as novel adjuvants to conventional antibiotics for treatment of infectious diseases caused by bacterial pathogens.
An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas
Authors: Guerzoni Clara , Amatori Stefano , Giorgi Luca , Manara Maria Cristina , Landuzzi Lorena , Lollini Pier-Luigi , Tassoni Aurora , Balducci Mauro , Manfrini Marco , Pratelli Loredana , Serra Massimo , Picci Piero , Magnani Mauro , Fusi Vieri , Fanelli Mirco , Scotlandi Katia 
Published: February 2014

Abstract

Background
Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and in vivo efficacy of a new maltol derived molecule (maltonis), belonging to the family of molecules named hydroxypyrones.

Methods
Maltonis was screened for its ability to induce structural alteration of DNA molecules in comparison to another maltolic molecule (malten). In vitro antitumour efficacy was tested using a panel of sarcoma cell lines, representative of Ewing sarcoma, osteosarcoma and rhabdomyosarcoma, the three most common paediatric sarcomas, and in normal human mesenchymal primary cell cultures. In vivo efficacy was tested against TC-71 Ewing sarcoma xenografts.

Results
Maltonis, a soluble maltol-derived synthetic molecule, was able to alter the DNA structure, inhibit proliferation and induce apoptotic cell death in paediatric sarcoma cells, either sensitive or resistant to some conventional chemotherapeutic drugs, such as doxorubicin and cisplatin. In addition, maltonis was able to induce: i) p21, p15 and Gadd45a mRNA upregulation; ii) Bcl-2, survivin, CDK6 and CDK8 down-regulation; iii) formation of γ-H2AX nuclear foci; iv) cleavage of PARP and Caspase 3. Two independent in vivo experiments demonstrated the tolerability and efficacy of maltonis in the inhibition of tumour growth. Finally maltonis was not extruded by ABCB1, one of the major determinants of chemotherapy failure, nor appeared to be a substrate of the glutathione-related detoxification system.

Conclusions
Considering that treatment of poorly responsive patients still suffers for the paucity of agents able to revert chemoresistance, maltonis may be considered for the future development of new therapeutic approaches for refractory metastatic patients.
Impact of caste on the neurodevelopment of young children from birth to 36 months of age: a birth cohort study in Chitwan Valley, Nepal
Authors: Parajuli Rajendra Prasad , Fujiwara Takeo , Umezaki Masahiro , Watanabe Chiho 
Published: February 2014

Abstract

Background
Caste, a proxy of socioeconomic position, can influence the neurodevelopment of children through several pathways, including exposure to toxic elements. Studies from developing countries where caste is represented by prevailing caste groups and people are highly exposed to toxic elements can provide useful insights into the mechanisms of neurodevelopmental inequities among children. This study aims to investigate the impact of caste on the neurodevelopment of children from birth to 36 months of age in Chitwan Valley, Nepal, where people are exposed to high levels of arsenic (As) and lead (Pb).

Methods
Participants (N = 94) were mother-infant pairs from the Chitwan district in Nepal. The neurodevelopment of the infants was assessed using the Brazelton Neonatal Behavioral Assessment Scale, Third Edition, (NBAS III) at birth and the Bayley Scales of Infant Development, Second Edition, (BSID II) at ages 6, 24, and 36 months. Caste was categorized based on surname, which, in Nepal generally refers to one of four caste groups. We also measured the concentrations of As and Pb in cord blood.

Results
Caste was positively associated with the state regulation cluster score of the NBAS III at birth after adjustment for covariates (p for trend < 0.01). Adding cord blood As levels attenuated the association (p for trend = 0.12). With regard to neurodevelopment at six months of age, the third-ranked caste group scored higher than the first-ranked caste group on the Mental Development Index (MDI) of the BSID II (coefficient = 3.7; 95% confidence interval (CI) = 1.3 to 6.0). This difference remained significant after adjustment for cord blood As levels and other covariates was made (coefficient = 3.9; 95% CI = 1.2 to 6.7). The remaining clusters of the NBAS III and BSID II at 6, 24, and 36 months were not significantly associated with caste group.

Conclusions
Caste was positively associated with the state regulation cluster score of NBAS III at birth. This association was partially mediated by cord blood As levels. However, the negative impact of caste on neurodevelopment disappeared as the children grew. Furthermore, an inverse association between caste and MDI at six months of age was observed. Additional studies are needed to elucidate the mechanism of how caste affects neurodevelopment.
Contractive multivalued maps in terms of Q-functions on complete quasimetric spaces
Authors: Karapınar Erdal , Romaguera Salvador , Tirado Pedro 
Published: February 2014

Abstract
In this paper we prove the existence of a fixed point for multivalued maps satisfying a contraction condition in terms of Q-functions, and via Bianchini-Grandolfi gauge functions, for complete

T
0

-quasipseudometric spaces. Our results extend, improve, and generalize some recent results in the literature. We present some examples to validate and illustrate our results.

MSC:54H25, 47H10, 54E50.