bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of one‐time placement of the definitive abutment versus multiple healing abutment disconnections and reconnections during the prosthetic phase on radiographic and clinical outcomes: A 12‐month randomized clinical trial
Authors: Calatrava Javier , Sanz‐Sánchez Ignacio , Molina Ana , Bollain Juan , Martín Conchita , Sanz Mariano 
Published: July 2024

AbstractObjectiveThe aim of this investigation was to evaluate the effect on clinical and radiological outcomes of the one‐abutment, one‐time protocol (test) versus placing the definitive abutment on the day of functional loading after having disconnected and connected three times the healing abutment during the prosthetic phase (control).Materials and methodsForty patients with 80 implants were randomly allocated to either the test or the control group. Changes in the radiographic marginal bone levels (MBLs), clinical outcomes, prosthetic‐related outcomes, and patient‐reported outcomes measures (PROMs) were assessed and compared 6 and 12 months after functional loading.ResultsThirty‐seven patients with 74 implants were followed at 12 months. A statistically significant bone remodeling was observed in both groups following implant placement. MBLs were significantly greater in the control group at the 6‐ (−0.13 mm vs. −0.61 mm) and 12‐month visits (−0.01 mm vs. −0.53 mm). Bone loss was significantly greater in the control group from surgery to 6 and 12 months and from loading to 6 and 12 months. The abutment height was significantly greater in the test group, however, there were no significant differences in the restorative angle. Similarly, there were no statistically significant differences between groups for the measured clinical variables (probing depth, plaque, and bleeding index) and PROMs.ConclusionsDisconnecting and reconnecting the healing abutment was associated with significantly higher bone loss after 12 months, as compared to the placement of the definitive abutment at implant installation.
Compromised cell competition exhausts neural stem cells pool
Authors: Li Chenxiao , Zhang Mengtian , Du Yushan , Liu Shuang , Li Da , Zhang Shukui , Ji Fen , Zhang Jingjing , Jiao Jianwei 
Published: July 2024

AbstractBlood vessels play a crucial role in maintaining the stem cell niche in both tumours and developing organs. Cell competition is critical for tumour progression. We hypothesise that blood vessels may act as a regulator of this process. As a pioneer, the secretions of blood vessels regulate the intensity of cell competition, which is essential for tumour invasion and developmental organ extension. Brd4 expresses highly in endothelial cells within various tumours and is positively correlated with numerous invasive genes, making it an ideal focal point for further research on the relationship between blood vessels and cell competition. Our results indicated that the absence of endothelial Brd4 led to a reduction in neural stem cell mortality and compromised cell competition. Endothelial Brd4 regulated cell competition was dependent on Testican2. Testican2 was capable of depositing Sparc and acted as a suppressor of Sparc. Compromised cell competition resulted in the depletion of neural stem cells and accelerated brain ageing. Testican2 could rescue the run‐off of neural stem cells and accelerate the turnover rate of neurons. AD patients show compromised cell competition. Through the cloning of a point mutant of Brd4 identified in a subset of AD patients, it was demonstrated that the mutant lacked the ability to promote cell competition. This study suggests a novel approach for treating age‐related diseases by enhancing the intensity of cell competition.
The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239
Authors: Huynh Christine , Dingemanse Jasper , Meyer zu Schwabedissen Henriette E. , Fonseca Marlene , Sidharta Patricia N. 
Published: July 2024

AbstractCytochrome P450 (CYP) 3A4 is an enzyme involved in the metabolism of many drugs that are currently on the market and is therefore a key player in drug–drug interactions (DDIs). ACT‐1004‐1239 is a potent and selective, first‐in‐class ACKR3/CXRC7 antagonist being developed as a treatment for demyelinating diseases including multiple sclerosis. Based on the human absorption, distribution, metabolism, and excretion (ADME) study results, ACT‐1004‐1239 is predominantly metabolized by CYP3A4. This study investigated the effect of the strong CYP3A4 inhibitor, itraconazole, on the pharmacokinetics of single‐dose ACT‐1004‐1239 in healthy male subjects. In the open‐label, fixed‐sequence DDI study, a total of 16 subjects were treated. Each subject received a single dose of 10 mg ACT‐1004‐1239 (Treatment A) in the first period followed by concomitant administration of multiple doses of 200 mg itraconazole and a single dose of 10 mg ACT‐1004‐1239 in the second period. We report a median of difference in tmax (90% confidence interval, CI) of 0.5 h (0.0, 1.0) comparing both treatments. The geometric mean ratio (GMR) (90% CI) of Cmax and AUC0−∞ was 2.16 (1.89, 2.47) and 2.77 (2.55, 3.00), respectively. The GMR (90% CI) of t1/2 was 1.46 (1.26, 1.70). Both treatments were well‐tolerated with an identical incidence in subjects reporting treatment‐emergent adverse events (TEAE). The most frequently reported TEAEs were headache and nausea. In conclusion, ACT‐1004‐1239 is classified as a moderately sensitive CYP3A4 substrate (i.e., increase of AUC ≥2‐ to <5‐fold), and this should be considered in further clinical studies if CYP3A4 inhibitors are concomitantly administered.
Association patterns of ketone bodies with the risk of adverse outcomes according to diabetes status
Authors: Li Jiang , Sun Ying , Yu Bowei , Cai Lingli , Shen Wenqi , Wang Bin , Tan Xiao , Guo Yuyu , Wang Ningjian , Lu Yingli 
Published: July 2024

AbstractAimTo investigate the associations between ketone bodies (KB) and multiple adverse outcomes including cardiovascular disease (CVD), chronic kidney disease (CKD) and all‐cause mortality according to diabetes status.MethodsThis prospective study included 222 824 participants free from CVD and CKD at baseline from the UK Biobank. Total KB including β‐hydroxybutyrate, acetoacetate and acetone were measured by nuclear magnetic resonance. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between KB and adverse outcomes among participants with normoglycaemia, prediabetes and type 2 diabetes, respectively.ResultsDuring a mean follow‐up of 14.1 years, 24 088 incident CVD events (including 17 303 coronary heart disease events, 5172 stroke events and 5881 heart failure [HF] events), 8605 CKD events and 15 813 deaths, were documented. Higher total KB significantly increased the risk of HF among participants with normoglycaemia (HR, 1.32 [95% CI, 1.17‐1.49], per 10‐fold increase in total KB) and prediabetes (1.35 [1.04‐1.76]), and increased the risk of CKD among those with normoglycaemia (1.20 [1.09‐1.33]). Elevated KB levels were associated with an increased risk of all‐cause mortality across the glycaemic spectrum (1.32 [1.23‐1.42] for normoglycaemia, 1.45 [1.24‐1.71] for prediabetes and 1.47 [1.11‐1.94] for diabetes). Moreover, a significant additive interaction between KB and diabetes status was observed on the risk of death (P = .009), with 4.9% of deaths attributed to the interactive effects.ConclusionsOur study underscored the variation in association patterns between KB and adverse outcomes according to diabetes status and suggested that KB could interact with diabetes status in an additive manner to increase the risk of mortality.
Type III fetal redundancy of the foramen ovale flap mimics hemodynamic changes of mitral stenosis
Authors: Peng Xiaohui , Zhang Panpan , Pan Mei , Hui Shanshan , Shen Tingting , You Liyi , Zhao Bowen 
Published: July 2024

AbstractType III redundancy of the foramen ovale flap (RFOF) mimics hemodynamic changes of mitral stenosis(MS), which has not been particularly highlighted in previous literature but carries a favorable prognosis.
Tracking shifts in forest structural complexity through space and time in human‐modified tropical landscapes
Authors: Rosen Alice , Jörg Fischer Fabian , Coomes David A. , Jackson Toby D. , Asner Gregory P. , Jucker Tommaso 
Published: July 2024

Habitat structural complexity is an emergent property of ecosystems that directly shapes their biodiversity, functioning and resilience to disturbance. Yet despite its importance, we continue to lack consensus on how best to define structural complexity, nor do we have a generalised approach to measure habitat complexity across ecosystems. To bridge this gap, here we adapt a geometric framework developed to quantify the surface complexity of coral reefs and apply it to the canopies of tropical rainforests. Using high‐resolution, repeat‐acquisition airborne laser scanning data collected over 450 km2 of human‐modified tropical landscapes in Borneo, we generated 3D canopy height models of forests at varying stages of recovery from logging. We then tested whether the geometric framework of habitat complexity – which characterises 3D surfaces according to their height range, rugosity and fractal dimension – was able to detect how both human and natural disturbances drive variation in canopy structure through space and time across these landscapes. We found that together, these three metrics of surface complexity captured major differences in canopy 3D structure between highly degraded, selectively logged and old‐growth forests. Moreover, the three metrics were able to track distinct temporal patterns of structural recovery following logging and wind disturbance. However, in the process we also uncovered several important conceptual and methodological limitations with the geometric framework of habitat complexity. We found that fractal dimension was highly sensitive to small variations in data inputs and was ecologically counteractive (e.g. higher fractal dimension in oil palm plantations than old‐growth forests), while rugosity and height range were tightly correlated (r = 0.75) due to their strong dependency on maximum tree height. Our results suggest that forest structural complexity cannot be summarised using these three descriptors alone, as they overlook key features of canopy vertical and horizontal structure that arise from the way trees fill 3D space.Keywords: Forest disturbance, LiDAR, logging, recovery, remote sensing, structural complexity
Elevating Black fathers' experiences in the National Fatherhood Initiative: Strengths and areas for improvement of 24/7 Dad® curriculum and case management services
Authors: Voith Laura A. , Russell Katie N. , Withrow Ashley , Kearney Jennifer , Xia Tian , Coleman Darrell 
Published: July 2024

AbstractThe Healthy Marriage and Responsible Fatherhood grant program is one of the most robust mechanisms supporting fatherhood programming in the United States, with the gold standard of care including fatherhood curriculum (e.g., 24/7 Dad®) and case management services. Despite the fact that fatherhood in the United States is not a monolith and Black fathers make up over 40% of those served through Responsible Fatherhood (RF) program, little research explicitly centers the lived experiences of low‐income Black fathers. The current study used focus groups with fathers (n = 23) and staff (n = 8) enrolled in a RF grantee program. Thematic analysis was used to determine programmatic mechanisms supporting these fathers' success and areas for improvement. Our findings highlight that the creation of a “safe space” by facilitators and the power of the group dynamic were essential elements for fathers' success overall. We also identified numerous programmatic mechanisms supporting Black fathers' success specific to fathering, healthy relationships, and economic stability. Finally, we highlighted important limitations that may impede the success of low‐income, Black fathers related to the 24/7 Dad® curriculum, engagement efforts, and economic stability, and discuss related practice, policy, and research recommendations.
Digitally Mobile Swedes and Their Experiences: A Contribution to the De‐Exceptionalization of Migrants
Authors: Åkesson Lisa 
Published: July 2024

ABSTRACTThis article challenges entrenched notions of otherness, which presuppose that migrants’ experiences always are inherently different from those of other people. By exploring the experiences of white, middle‐class, highly educated Swedes living in Sweden, I highlight some similarities with challenges traditionally attributed solely to migrants. Drawing on ethnographic fieldwork conducted in the Swedish hub of a large international company, the article examines experiences of Swedish employees participating in international digital meetings, a significant aspect of their daily professional lives. It elucidates aspects of their experiences that are often associated with migrants: struggling with language, feeling dominated and unseen and striving to adapt while subtly challenging the dominance of British and American ‘natives’ through practices of boundary maintenance. The article contributes to the de‐exceptionalization of migrants’ experiences without further equating the privileged Swedes’ living conditions with those of people who are migranticized and subjected to enduring othering in their everyday lives.
‘There's Nothing Wrong With You; You Just Need to Lose Weight’—A Qualitative Exploration of Pelvic Floor Dysfunction Among Women With Multiple Sclerosis and Their Interaction in Seeking Pelvic Healthcare
Authors: Addington Christine , Bradshaw Andy , Hagen Suzanne , McClurg Doreen 
Published: July 2024

AbstractIntroductionWithin 10 years of multiple sclerosis (MS) progression, nearly all women will have experienced symptoms associated with bladder, bowel and/or sexual health. Yet despite the impact these symptoms have on physical, psychological and social well‐being, it remains an underserved area within the UK healthcare system.Study AimThis research employs a participatory research approach framed within the principles of intersectional feminism to collaboratively investigate the lived experiences of pelvic floor dysfunction (PFD) and healthcare interactions among UK‐based women with MS.Setting and ParticipantsWomen residing in the United Kingdom with MS were invited to participate in online interviews facilitated by the primary author.AnalysisA thematic framework analysis offering a structured yet adaptable approach to data collection and interpretation.ResultsOne focus group involving four women with MS and seven individual, one‐to‐one interviews with women with MS provided insights into the challenges associated with navigating both MS and PFD. Four main themes included: Navigating MS and PFD; Cycles of Control; Mind, Mobility and Bladder Embodiment; Silenced Voices: The Impact of Taboos/Stigma/Dismissal on Preventing Access and Resistance through Collective Community. Six subthemes were also identified. Taken together, these themes cumulatively reflect PFD as an unmet healthcare need.ConclusionOur findings underscore negative healthcare experiences, inadequate information provision and unmet needs related to PFD, emphasising the compounding effects of gender and disability biases.ImpactWe hope that these insights can lay the groundwork for developing tailored therapeutic interventions and improved PFD healthcare for women with MS. Potential solutions include using existing MS support communities.Public ContributionsWomen with MS were actively involved in co‐producing interview scripts for one‐to‐one interviews. The primary author shared study findings at an MS group event, engaging in discussions with over 30 individuals, including people with MS and their loved ones. MS advocates played a pivotal role in contextualising the study within the broader lived experience of MS.
Easing down foreign language listening anxiety: Metacognitive intervention and dialogic interaction
Authors: Bozorgian Hossein , Fallahpour Mohammad Reza , Taghizade Motahare 
Published: July 2024

AbstractListening comprehension (LC) occurs when listeners can reasonably interpret a speaker's intention; therefore, reducing foreign language listening anxiety (FLLA) among EFL (English as a Foreign Language) learners significantly facilitates their comprehension. Accordingly, the present study was designed to determine the effect of metacognitive intervention (MI) and metacognitive intervention through dialogic interaction (MIDI) on EFL learners’ FLLA. A mixed methods approach was used to hire 90 all‐male, advanced undergraduate students majoring in TEFL (Teaching English as a Foreign Language), ranging from 18 to 22 years of age, who participated in three groups. The first two groups (N = 60) were experimental groups that received 8 weeks of intervention programs within an 11‐session study focusing on MI and MIDI. Simultaneously, the control group (N = 30) listened to the same audio files the same number of times but without any attention paid to MI or MIDI, and there was no discussion of strategy use after each session. To fulfill the aim of the study, a validated questionnaire on the FLLA scale, IELTS listening recordings along with listening guide sheets and IELTS listening samples, and semi‐structured interviews to investigate learners’ attitudes toward intervention sessions’ effect on their LC and anxiety level were used. The results provided some empirical support that learners benefit from MI and specifically MIDI to reduce the level of their FLLA and further improve LC.
An audit for the inpatient management of patients with severe hypertension without acute end‐organ damage at the Northern Sydney Local Health District
Authors: Kolovos Peter , Esterman Dominic A. , Lynch Grace , Pearson Katheryn , Nanayakkara Upeka , Mather Amanda 
Published: July 2024

AbstractSevere hypertension without acute end‐organ damage is commonly encountered in inpatients. Despite this, there is a lack of international guidelines to manage this disorder. We conducted an audit to investigate the local practices within our health district. Current practices favour the use of rapidly acting antihypertensive drugs, which have been associated with iatrogenic injury.
Effectiveness of Cognitive‐Based Interventions on Psychological Distress in Adolescents With Physical Disabilities: A Systematic Review and Meta‐Analysis
Authors: Li Jiaying , Li Yan , Mei Xiaoxiao , He Honggu , Yu Lu , Ho Grace Wing Ka , Chan Engle Angela 
Published: July 2024

ABSTRACTAdolescents with physical disabilities experience common psychological distress that interacts with impaired physical function. While cognitive‐based interventions have been implemented for adolescents with physical disabilities, their effects on enhancing psychological health remain uncertain. This systematic review aimed to synthesise the effects of cognitive‐based interventions on the psychological distress of this population and identify optimal components for evidence‐based interventions. Following the PRISMA guideline, nine databases were searched to identify eligible randomised controlled trials examining the effects of cognitive‐based interventions for adolescents with physical disabilities from inception to October 2023. Data syntheses were performed using the R software, employing random‐effects models. Twelve trials involving 1201 participants were identified. The pooled results revealed that cognitive‐based interventions did not yield noticeable effects in reducing anxiety (g = −0.43 for postintervention; −0.14 for medium term; −0.37 for long term), depression (g = −0.05 for postintervention; −0.02 for medium term; −0.15 for long term) and stress levels (g = −0.15) over time. The secondary outcome (physical function) improved significantly in the long term compared to the control groups (g = 0.31). Furthermore, this review identified variations in the effectiveness of CBIs among different recipients, durations and modes of delivery. Given the limited number and overall low quality of identified studies for each outcome, conducting high‐quality randomised controlled trials is recommended to validate the effectiveness of cognitive‐based interventions in reducing psychological distress among adolescents with physical disabilities.
Identifying Protective and Risk Factors for Non‐Suicidal Self‐Injury Among Young Adults in Korea: Insights From Problem Behaviour Theory
Authors: Oh Danbi , Na Hyunjoo 
Published: July 2024

ABSTRACTThis study aimed to identify protective and risk factors related to non‐suicidal self‐injury (NSSI) behaviour among young adults in their 20s in Korea, providing an integrated perspective based on the Problem Behaviour Theory (PBT). The subjects were 650 young people in their 20s recruited through the promotion of mental health welfare centres in Seoul, Gyeonggi‐do and Jeju‐si in Korea. A self‐report scale was used to measure NSSI and resilience, social support, self‐compassion, childhood adversity, depression, anxiety and anger. The collected data were analysed using the SPSS 27.0 program, and hierarchical logistic regression analysis was performed to identify the protective and risk factors related to NSSI behaviour. As a result of this study, out of 650 participants, 107 (16.46%) were found to have experienced NSSI. The NSSI group was younger and had a higher proportion of females compared with the non‐NSSI group. In addition, self‐compassion was identified as a protective factor and childhood adversity and depression were identified as risk factors associated with NSSI behaviour. The lower the self‐compassion, the higher the childhood adversity and the higher the depression, the higher the likelihood of NSSI behaviour. Based on the results, mental health services should be provided to young people with childhood adversity and high levels of depression, and efforts should be made to respond appropriately to self‐injury crises. In addition, it is considered necessary to develop a program to increase the level of self‐compassion to protect against the NSSI behaviour of young people in their 20s in Korea.
Antibody Response to Symptomatic Infection With SARS‐CoV‐2 Omicron Variant Viruses, December 2021–June 2022
Authors: Sandford Ryan , Yadav Ruchi , Noble Emma K. , Sumner Kelsey , Joshi Devyani , Tartof Sara Y. , Wernli Karen J. , Martin Emily T. , Gaglani Manjusha , Zimmerman Richard K. , Talbot H. Keipp , Grijalva Carlos G. , Belongia Edward A. , Carlson Christina , Coughlin Melissa , Flannery Brendan , Pearce Brad , Rogier Eric 
Published: July 2024

ABSTRACTWe describe humoral immune responses in 105 ambulatory patients with laboratory‐confirmed SARS‐CoV‐2 Omicron variant infection. In dried blood spot (DBS) collected within 5 days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189 units/mL and by a factor of 47 against N protein from 5.5 to 259 units/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS‐CoV‐2 infection.