bluuebunny/crossref_metadata_2025_split huggingface dataset:
An intelligent decision supporting system for international classification of functioning, disability, and health
Authors: Hsieh Wei-Fen , Chen Lieu-Hen , Hung Hao-Ming , Sato-Shimokawara Eri , Takama Yasufumi , Yamaguchi Toru , Wu Eric Hsiao-Kuang , Chen Yu-Wei 
Published: April 2015

Abstract

Background
In recent years, the population structure in Taiwan has changed so dramatically. Based on concerns of social welfare issues, Taiwanese government began to seek principles for assessment of disability. After seven years of carefully evaluation, the World Health Organization’s International Classification of Functioning, Disability, and Health (Abbreviated to ICF) is officially adopted as Taiwan’s assessment standard while most of the assessment procedures of ICF are sophisticated, and time consuming.
In this paper, we propose a sensor based decision supporting system for ICF. Our prototype system aims to reduce the burden of medical staffs, and to assist subjects to perform the assessments.

Methods
This paper integrate multiple devices including ASUS XtionTM, temperature/acceleration/gyro sensors on Arduino, and Zigbee to measure the mobility of limbs and joints. The subject’s log of assessments is then recorded in the database so that the medical staffs can remote-monitor the co ndition of subjects immediately, and analyze the results later. Additionally, in our system, a user-friendly interface is implemented for the detection of dementia.

Results
In this paper, three experiments have been conducted for different purpose. The experiment was conducted to compare the variation between thermometer and our device. Moreover, we invited 20 elders aged for 65 to 80 to use our system and all of them gave positive feedback. Two elders were invited to perform full assessment for dementia and the results show that both of them didn’t have sign of dementia. Also, the assessment of joint movement was performed by a 67 year-old elder and the result shows that the elder had well physical function and could take care of daily life.

Conclusions
The proposed system has potential for aiding users to perform the ICF testing better and provide benefits to medical staffs and society. With current technology, integration between sensor network systems and artificial intelligence approaches will more and more important. We develop a simple interface for user to manipulate and perform the ICF assessment. In addition, the early detection of dementia likely has the potential to provide patients with an increased level of precaution, which may improve quality of life.
EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB–Expressing Breast Cancer
Authors: Yardley Denise A. , Weaver Robert , Melisko Michelle E. , Saleh Mansoor N. , Arena Francis P. , Forero Andres , Cigler Tessa , Stopeck Alison , Citrin Dennis , Oliff Ira , Bechhold Rebecca , Loutfi Randa , Garcia Agustin A. , Cruickshank Scott , Crowley Elizabeth , Green Jennifer , Hawthorne Thomas , Yellin Michael J. , Davis Thomas A. , Vahdat Linda T. 
Published: April 2015

Purpose Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types. Glembatumumab vedotin is a gpNMB-specific monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin E. This phase II study investigated the activity of glembatumumab vedotin in advanced breast cancer by gpNMB expression. Patients and Methods Patients (n = 124) with refractory breast cancer that expressed gpNMB in ≥ 5% of epithelial or stromal cells by central immunohistochemistry were stratified by gpNMB expression (tumor, low stromal intensity, high stromal intensity) and were randomly assigned 2:1 to glembatumumab vedotin (n = 83) or investigator's choice (IC) chemotherapy (n = 41). The study was powered to detect overall objective response rate (ORR) in the glembatumumab vedotin arm between 10% (null) and 22.5% (alternative hypothesis) with preplanned investigation of activity by gpNMB distribution and/or intensity (Stratum 1 to Stratum 3). Results Glembatumumab vedotin was well tolerated as compared with IC chemotherapy (less hematologic toxicity; more rash, pruritus, neuropathy, and alopecia). ORR was 6% (five of 83) for glembatumumab vedotin versus 7% (three of 41) for IC, without significant intertreatment differences for predefined strata. Secondary end point revealed ORR of 12% (10 of 83) versus 12% (five of 41) overall, and 30% (seven of 23) versus 9% (one of 11) for gpNMB overexpression (≥ 25% of tumor cells). Unplanned analysis showed ORR of 18% (five of 28) versus 0% (0 of 11) in patients with triple-negative breast cancer (TNBC), and 40% (four of 10) versus 0% (zero of six) in gpNMB-overexpressing TNBC. Conclusion Glembatumumab vedotin is well tolerated in heavily pretreated patients with breast cancer. Although the primary end point in advanced gpNMB-expressing breast cancer was not met for all enrolled patients (median tumor gpNMB expression, 5%), activity may be enhanced in patients with gpNMB-overexpressing tumors and/or TNBC. A pivotal phase II trial (METRIC [Metastatic Triple-Negative Breast Cancer]) is underway.
TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer
Authors: Isakoff Steven J. , Mayer Erica L. , He Lei , Traina Tiffany A. , Carey Lisa A. , Krag Karen J. , Rugo Hope S. , Liu Minetta C. , Stearns Vered , Come Steven E. , Timms Kirsten M. , Hartman Anne-Renee , Borger Darrel R. , Finkelstein Dianne M. , Garber Judy E. , Ryan Paula D. , Winer Eric P. , Goss Paul E. , Ellisen Leif W. 
Published: April 2015

Purpose The identification of patients with metastatic triple-negative breast cancer (mTNBC) who are expected to benefit from platinum-based chemotherapy is of interest. We conducted a single-arm phase II clinical trial of single-agent platinum for mTNBC with biomarker correlates. Patients and Methods Patients with mTNBC received first- or second-line cisplatin (75 mg/m2) or carboplatin (area under the concentration-time curve 6) by physician's choice once every 3 weeks. Coprimary end points were objective response rate (RR) and response prediction by p63/p73 gene expression. Secondary and exploratory end points included toxicity assessment, RR in cisplatin versus carboplatin, and RR in molecularly defined subgroups, including BRCA1/2 mutation carriers. Results Patients (N = 86; 69 as first-line therapy) received cisplatin (n = 43) or carboplatin (n = 43). RR was 25.6% (95% CI, 16.8% to 36%) and was numerically higher with cisplatin (32.6%) than with carboplatin (18.7%). RR was 54.5% in patients with germline BRCA1/2 mutations (n = 11). In patients without BRCA1/2 mutations (n = 66), exploratory analyses showed that a BRCA-like genomic instability signature (n = 32) discriminated responding and nonresponding tumors (mean homologous recombination deficiency–loss of heterozygosity/homologous recombination deficiency–large-scale state transitions [HRD-LOH/HRD-LST] scores were 12.68 and 5.11, respectively), whereas predefined analysis by p63/p73 expression status (n = 61), p53 and PIK3CA mutation status (n = 53), or PAM50 gene expression subtype (n = 55) did not. Five of the six long-term responders alive at a median of 4.5 years lacked germline BRCA1/2 mutations, and two of them had increased tumor HRD-LOH/HRD-LST scores. Conclusion Platinum agents are active in mTNBC, especially in patients with germline BRCA1/2 mutations. A measure of tumor DNA repair function may identify patients without mutations who could benefit from platinum therapy agents. Prospective controlled confirmatory trials are warranted.
GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species
Authors: Kim Taeshin , Lawson Mark A. 
Published: April 2015

AbstractThe appropriate control of synthesis and secretion of the gonadotropin hormones LH and FSH by pituitary gonadotropes is essential for the regulation of reproduction. The hypothalamic neuropeptide GnRH is the central regulator of both processes, coordinating secretion with transcription and translation of the gonadotropin hormone subunit genes. The MAPK family of second messengers is strongly induced in gonadotropes upon GnRH stimulation, and multiple pathways activate these kinases. Intracellular reactive oxygen species participate in signaling cascades that target MAPKs, but also participate in signaling events indicative of cell stress. The NADPH oxidase (NOX)/dual oxidase (DUOX) family is a major enzymatic source of intracellular reactive oxygen, and we show that GnRH stimulation of mouse primary pituitary cells and the LβT2 gonadotrope cell line elevates intracellular reactive oxygen via NOX/DUOX activity. Mouse pituitary and LβT2 cells abundantly express NOX/DUOX and cofactor mRNAs. Pharmacological inhibition of NOX/DUOX activity diminishes GnRH-stimulated activation of MAPKs, immediate-early gene expression, and gonadotropin subunit gene expression. Inhibitor studies implicate the calcium-activated DUOX family as a major, but not exclusive, participant in GnRH signaling. Knockdown of DUOX2 in LβT2 cells reduces GnRH-induced Fshb, but not Lhb mRNA levels, suggesting differential sensitivity to DUOX activity. Finally, GnRH pulse-stimulated FSH and LH secretion are suppressed by inhibition of NOX/DUOX activity. These results indicate that reactive oxygen is a potent signaling intermediate produced in response to GnRH stimulation and further suggest that reactive oxygen derived from other sources may influence the gonadotrope response to GnRH stimulation.
Perovskite Photovoltaics: Rare Functions of Organo Lead Halide in Solar Cells and Optoelectronic Devices
Authors: Miyasaka Tsutomu 
Published: April 2015

Abstract
Organo-lead halide perovskite compounds, otherwise called organic–inorganic hybrid perovskite, represented by CH3NH3PbI3, exhibit many rare functions as narrow-band-gap semiconductors that are superior in applications for photovoltaic power conversion as well as for high-gain photon-mode detection of visible light. In this review, photoelectric properties of solution-processed CH3NH3PbI3 films and future perspectives in low-cost device fabrication are discussed based on our investigations.
Facilitating Effects of Group Behavior
Authors: Красовский  , Krasovskiy Yuriy 
Published: April 2015

The paper describes specifi c ways, in which the phenomenon of social facilitation manifests itself in the teamwork of an organizational unit staff , peculiarities
of teamwork under specifi c conditions, the role of a leader, i.e. moderator, in arranging the workers’ successful creative activities. Also analyzed are typical
mistakes in moderators’ behavior, being the result of ignorance of certain social and psychological patterns. The paper provides concrete managerial cases
and algorithms on how to assess each case, shows how the group standard-setting process works; describes six alternatives of how role leadership positions
can come into play and specifi cs of little groups formation under the conditions of spontaneous set-up and consolidation of group standards of conduct, group
sanctions of group opinions, group diversity of roles and statuses in the context of any given group orientation towards a leadership position, which can
manifest itself in various role-playing combinations. Also proposed are basic criteria to assess how well organizational culture of management is being shaped.
The paper in based on the author’s personal experience in moderating, managing and consulting with respect to his work with the large US-Russian holding
company (embracing 24 fi rms) as the Director for Strategic Development and Human Resource Management.
Personnel Support for Regional Development
Authors: Симонова  , Simonova Marina 
Published: April 2015

This paper examines trends in the qualitative and quantitative development of the human resources of the Volga. Analysis of trends is based on statistics. The
basic possibility of compensation quantitative reduction of labor. It is proved that on the basis of the quality of the workforce with innovative features can
increase the competitiveness of all areas of the economy and create breakthrough technologies. Quantitative characteristics of human resources in the region
are formed on the basis of natural and migratory movements and are infl uenced by numerous objective and subjective factors that are both national and
regional peculiarities. Overcoming the negative demographic trends is an important regional task, consistent solution which can allow to change the existing
situation reduction of natural increase and reach the simple reproduction in the medium term. Important resource for attracting migrants in the Volga region
is the system of vocational education, which has a fairly high level of development and strong potential for growth.
Competition to Fill Vacancies of Civil Servants As the Instrument of Career Growth
Authors: Буканин  , Bukanin S. 
Published: April 2015

The paper analyzes effi ciency of competition to fi ll vacancies at the public offi ces, as an instrument for civil servants’ career development. The legal and regulatory
framework and methodical guidelines for civil servants competitive selection are considered in the context of improving the system of career growth at civil
services. Based on the results of empirical study, conducted by the author in order to identify civil servants attitudes to the mechanism of competitive selection,
the author provides proposals on how to improve mechanisms of fi lling vacancies at civil offi ces, including reforming the system of selection fi rst-time applicants
to civil service jobs as well as the system for fi lling vacancies and maintaining highly professional personnel reserve. Considered also are perspectives for
introducing amendments to legal frameworks, regulating the procedure of competitive selection of civil servants.
Employment Problems of Disabled
Authors: Семенова  , Semenova I. , Борисова  , Borisova N. 
Published: April 2015

The problem of employment is especially acute nowadays for disabled people. At the heart of problem is a confl ict between legal requirements to employ people
with disabilities on the one part, and reluctance of employers to employ the disabled, on the other part. Municipal employment centers in cooperation with
other involved agencies try to fi nd proper jobs for disabled workers, in the process implementing recommendations of individual professional rehabilitation
programs. Based on analysis of the current situation the conclusion is made, that job seekers with disabilities usually encounter especially aggravated diffi culties
when trying to obtain employment by themselves. The paper considers the most frequent reasons for denials of employment to disabled job seekers and resulting
social and psychological problems. Advantages of having disabled workers at staff , opportunities of inclusive education and distance work as an employing
option for a disabled individual are outlined.
The Main Objectives and Principles of Socio-Economic Forecasting
Authors: Суворов  , Suvorov Anatoliy , Ивантер  , Ivantyer Viktor , Сутягин  , Sutyagin Valyeriy 
Published: April 2015

The methodological foundations of socio-economic forecasting are considered in this paper. The forecasting’s
definition is given; the forecasting’s role and place in national economy regulation are considered. Forecasts
types’ classification and the forecasting’s basic principles have been presented. Forecasting models’
structure and classification, as well as socio-economic forecasts’ elements and development stages have
been considered.
Personnel Management in the Public Service in the Context of the Modernization Process in Kazakhstan
Authors: Досымбекова  , Dosymbekova Roza 
Published: April 2015

The article presents the results of a study of modern public service modernization in the period of
administrative reform in Kazakhstan. In the administrative aspect of the emphasis on human resource
component in the process of implementation of the administrative reform, transformation and optimization of
state bodies. The issues of organizational effectiveness, new technological processes in the activities of civil
servants. Formation of Kazakhstan’s statehood is closely linked with a wide range of issues of theoretical
and practical understanding of human resource management in the public service.
Multiperiod Bus Timetabling
Authors: Ibarra-Rojas Omar J. , López-Irarragorri Fernando , Rios-Solis Yasmin A. 
Published: April 2015

The timetabling subproblem of bus transit network planning determines the departure times for all trips of the lines along the entire day. Most of the public transport networks consider planning periods identical for all lines. In this study we drop this strong assumption by introducing specific periods for each line, which is more realistic. Thus, we propose the multiperiod synchronization bus timetabling (MSBT) problem, which specifies the departure times of the trips of all lines where each line has its own planning periods along the day, with the objective of optimizing synchronization events: maximize passenger transfers and minimize bus bunching along the network. We propose an integer linear programming formulation for the MSBT problem and analyze the structural properties of this formulation by a constraint propagation methodology. These properties are the basis for different operators that lead to the design of efficient metaheuristics for solving the problem. We empirically obtain high-quality feasible solutions for real size instances and show that by considering a multiperiod approach, synchronization events of trips belonging to different planning periods are not ignored, as it is the case when several single period timetables are merged.
The role of anti-arrhythmic drugs for AF rhythm control
Authors: Fhadil Sadeer , Wright Paul 
Published: April 2015

Background: Atrial fibrillation is the most common sustained cardiac arrhythmia. Although anti-arrhythmic agents have been used for over 100 years, paradoxical arrhythmias and non-cardiac toxicity, coupled with suboptimal efficacy has limited their use, creating a gap. Current options: Safety and efficacy of commonly used anti-arrhythmic agents were reviewed, illustrating variable long-term efficacy and undesirable side-effect profiles. A newer agent, dronedarone, addressed some of the problems associated with amiodarone use but is less effective at long-term rhythm control and has been associated with increased mortality in certain patient subgroups. Conclusion: It is clear that there is still a role for older anti-arrhythmic agents and although dronedarone has taken steps to rectify safety concerns, it has done so with a lower efficacy. Promising new agents are on the horizon that aim to address these limitations and transform the way in which atrial fibrillation is managed pharmacologically.
The pyschological burden of a relative's CICU admission
Authors: Eshah Nidal , Rayan Ahmad H 
Published: April 2015

Background: Individuals' emotions are challenged when encountering serious conflicts originating from having a relative admitted to the cardiac intensive care unit (CICU). Objectives: To assess the prevalence of depression, anxiety and stress, and to identify factors associated with these emotions among relatives of Jordanian patients admitted to CICU. Methods: This descriptive study recruited 164 participants through a convenience-sampling technique. Lazarus and Folkman's (1984) theory constituted the theoretical structure for the study, and psychological burdens were measured through the Depression Anxiety and Stress Scale (DASS) ( Lovibond and Lovibond, 1995 ). Results: 33.6%, 48.2%, and 39% of participants had moderate-to-extremely severe levels of depression, anxiety, and stress respectively. Psychological burdens were associated with family members' gender and educational level, and the patient's condition. Among family members, spouses reported the highest level of psychological burden. Conclusions: Relatives' ability to live balanced psychological lives was significantly influenced by having a family member residing in CICU. Nurses should address relatives' psychological status in their care plans.
Changes of Chemical Composition, Crystallinity, and Fourier Transform Infrared Spectra of Eucalypt pellita Wood under Different Vacuum Heat Treatment Temperatures
Authors: Wang Xuehua , Wu Zhihui , Fang Lu , Wei Penglian , Fei Benhua , Liu Junliang 
Published: April 2015

Abstract
Heat treatment is one effective method of improving dimensional stability and durability of wood. However, it usually decreases the bending strength of wood. Vacuum heat treatment, which is one way that does not use a thermal medium, had little influence on wood elasticity or bending strength in our previous study. But until now, few studies have reported on the changing mechanism of vacuum heat–treated wood. In this article, chemical composition and crystallinity of untreated and treated Eucalypt pellita wood were investigated under vacuum heat treatment temperatures from 80°C to 280°C for 4 hours. The results showed that lignin content increased and that holocellulose and α-cellulose decreased when the temperature was raised. Alcohol benzene extractive increased at the initial stage and then decreased when the temperature was above 240°C. Crystallinity of wood increased with a temperature increase from 80°C to 200°C and reached a maximum value of 52.57 percent. Fourier transform infrared spectroscopy analysis indicated that absorption intensity of a benzene skeleton at 1,600 cm−1 increased and that the hydrogen bond absorption band at 3,423 cm−1 shifted to a lower wave number as temperature increased.
Noninvasive Prenatal Diagnosis of Duchenne Muscular Dystrophy: Comprehensive Genetic Diagnosis in Carrier, Proband, and Fetus
Authors: Yoo Seong-Keun , Lim Byung Chan , Byeun Jiyoung , Hwang Hee , Kim Ki Joong , Hwang Yong Seung , Lee JoonHo , Park Joong Shin , Lee Yong-Sun , Namkung Junghyun , Park Jungsun , Lee Seungbok , Shin Jong-Yeon , Seo Jeong-Sun , Kim Jong-Il , Chae Jong Hee 
Published: April 2015

AbstractBACKGROUNDNoninvasive prenatal diagnosis of monogenic disorders using maternal plasma and targeted massively parallel sequencing is being investigated actively. We previously demonstrated that comprehensive genetic diagnosis of a Duchenne muscular dystrophy (DMD) patient is feasible using a single targeted sequencing platform. Here we demonstrate the applicability of this approach to carrier detection and noninvasive prenatal diagnosis.METHODSCustom solution-based target enrichment was designed to cover the entire dystrophin (DMD) gene region. Targeted massively parallel sequencing was performed using genomic DNA from 4 mother and proband pairs to test whether carrier status could be detected reliably. Maternal plasma DNA at varying gestational weeks was collected from the same families and sequenced using the same targeted platform to predict the inheritance of the DMD mutation by their fetus. Overrepresentation of an inherited allele was determined by comparing the allele fraction of 2 phased haplotypes after examining and correcting for the recombination event.RESULTSThe carrier status of deletion/duplication and point mutations was detected reliably through using a single targeted massively parallel sequencing platform. Whether the fetus had inherited the DMD mutation was predicted correctly in all 4 families as early as 6 weeks and 5 days of gestation. In one of these, detection of the recombination event and reconstruction of the phased haplotype produced a correct diagnosis.CONCLUSIONSNoninvasive prenatal diagnosis of DMD is feasible using a single targeted massively parallel sequencing platform with tiling design.