bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of Pain Phenotypes in Knee Osteoarthritis: A Latent Class Analysis Using Data From the Osteoarthritis Initiative
Authors: Kittelson Andrew J. , Stevens‐Lapsley Jennifer E. , Schmiege Sarah J. 
Published: September 2015

ObjectiveKnee osteoarthritis (OA) is a broadly applied diagnosis that may describe multiple subtypes of pain. The purpose of this study was to identify phenotypes of knee OA, using measures from the following pain‐related domains: 1) knee OA pathology, 2) psychological distress, and 3) altered pain neurophysiology.MethodsData were selected from a total of 3,494 participants at visit 6 of the Osteoarthritis Initiative study. Latent class analysis was applied to the following variables: radiographic OA severity, quadriceps strength, body mass index, the Charlson Comorbidity Index (CCI), the Center for Epidemiologic Studies Depression Scale, the Coping Strategies Questionnaire‐Catastrophizing subscale, number of bodily pain sites, and knee joint tenderness at 4 sites. The resulting classes were compared on the following demographic and clinical factors: age, sex, pain severity, disability, walking speed, and use of arthritis‐related health care.ResultsA 4‐class model was identified. Class 1 (4% of the study population) had higher CCI scores. Class 2 (24%) had higher knee joint sensitivity. Class 3 (10%) had greater psychological distress. Class 4 (62%) had lesser radiographic OA, little psychological involvement, greater strength, and less pain sensitivity. Additionally, class 1 was the oldest, on average. Class 4 was the youngest, had the lowest disability, and least pain. Class 3 had the worst disability and most pain.ConclusionFour distinct pain phenotypes of knee OA were identified. Psychological factors, comorbidity status, and joint sensitivity appear to be important in defining phenotypes of knee OA–related pain.
Relationship Between Disease Characteristics and Oral Radiologic Findings in Systemic Sclerosis: Results From a Canadian Oral Health Study
Authors: Baron Murray , Hudson Marie , Dagenais Marie , Macdonald David , Gyger Geneviève , El Sayegh Tarek , Pope Janet , Fontaine Audrey , Masetto Ariel , Matthews Debora , Sutton Evelyn , Thie Norman , Jones Niall , Copete Maria , Kolbinson Dean , Markland Janet , Nogueira‐Filho Getulio , Robinson David , Fritzler Marvin , Wang Mianbo , Gornitsky Mervyn 
Published: September 2015

ObjectiveSystemic sclerosis (SSc; scleroderma) is associated with a wide periodontal ligament (PDL) and mandibular erosions. We investigated the clinical correlates of SSc with these radiologic abnormalities.MethodsSubjects from the Canadian Scleroderma Research Group cohort underwent detailed radiologic examinations. Associations between radiologic abnormalities and clinical manifestations of SSc were examined with univariate and multivariate analyses.ResultsThe study included 159 subjects; 90.6% were women, the mean ± SD age was 56 ± 10 years, diffuse disease was present in 28.3%, and mean ± SD disease duration was 13.7 ± 8.4 years. Widening of the PDL involving at least 1 tooth was present in 38% of subjects, and 14.5% had at least 1 site in the mandible with an erosion. In analyses adjusting for age, disease duration, sex, smoking, and education, we found significant associations between the number of teeth with widening of the PDL and disease severity assessed by the physician global assessment (PGA) (relative risk [RR] 1.19, 95% confidence interval [95% CI] 1.02–1.39, P = 0.028). Analyses replacing the PGA with the skin score, disease subset, or anti–topoisomerase I antibodies confirmed the relationship with indices of disease severity. There was no relationship between either the number of teeth with periodontal disease or the number of missing teeth, and the number of teeth with wide PDL. A smaller interdental distance (RR 0.89, 95% CI 0.82–0.97, P = 0.006), but not disease severity, facial skin score, or ischemia was associated with a larger number of erosions.ConclusionIn SSc, a wide PDL may reflect generalized overproduction of collagen, and mandibular erosions are related to local factors in the oral cavity.
Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises
Authors: de Lautour Hugh , Taylor William J. , Adebajo Ade , Alten Rieke , Burgos‐Vargas Ruben , Chapman Peter , Cimmino Marco A. , da Rocha Castelar Pinheiro Geraldo , Day Ric , Harrold Leslie R. , Helliwell Philip , Janssen Matthijs , Kerr Gail , Kavanaugh Arthur , Khanna Dinesh , Khanna Puja P. , Lin Chingtsai , Louthrenoo Worawit , McCarthy Geraldine , Vazquez‐Mellado Janitzia , Mikuls Ted R. , Neogi Tuhina , Ogdie Alexis , Perez‐Ruiz Fernando , Schlesinger Naomi , Ralph Schumacher H. , Scirè Carlo A. , Singh Jasvinder A. , Sivera Francisca , Slot Ole , Stamp Lisa K. , Tausche Anne‐Kathrin , Terkeltaub Robert , Uhlig Till , van de Laar Mart , White Douglas , Yamanaka Hisashi , Zeng Xuejun , Dalbeth Nicola 
Published: September 2015

ObjectiveTo establish consensus for potential remission criteria to use in clinical trials of gout.MethodsExperts (n = 88) in gout from multiple countries were invited to participate in a web‐based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete‐choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined.ResultsThere were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate (<0.36 mm), pain (<2 on a 10‐point scale), and patient global assessment (<2 on a 10‐point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission, with equal responses for 6 months (51%) and 1 year (49%). In the discrete‐choice experiment, there was a preference towards 12 months as a timeframe for remission.ConclusionThese consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain, and patient global assessment. These preliminary criteria now require testing in clinical data sets.
Poverty, Depression, or Lost in Translation? Ethnic and Language Variation in Patient‐Reported Outcomes in Rheumatoid Arthritis
Authors: Katz Patricia P. , Barton Jennifer , Trupin Laura , Schmajuk Gabriela , Yazdany Jinoos , Ruiz Pedro J. , Yelin Edward 
Published: September 2015

ObjectiveDespite advances in therapies, disparities in outcomes have been documented for rheumatoid arthritis (RA) patients for both ethnicity and English language proficiency. The goals of these analyses were to compare differences in RA patient‐reported outcomes, by both self‐identification of ethnicity and English language proficiency, and to identify factors that might explain differences among groups.MethodsData were collected through structured telephone interviews of a longitudinal cohort with physician‐diagnosed RA (n = 438); only women were included (n = 335). Three groups were defined based on self‐reported ethnicity and English proficiency: white/English (n = 219), Hispanic/English (n = 39), and Hispanic/Spanish (n = 77). Outcomes examined were patient‐reported physical functioning, pain, and presence of moderate or severe fatigue. Multivariate regression analyses compared outcomes among groups, adjusting for sociodemographic characteristics, health and disease factors, and depression.ResultsHispanic/Spanish women had worse function, pain, and fatigue than either English‐proficient group. Depression was associated with all outcomes (P < 0.0001), and accounted for greater differentials in scores than ethnicity/language proficiency. In interaction analyses, differences between women who were and were not depressed were greater for Hispanic/English than for Hispanic/Spanish. Nondepressed Hispanic/Spanish scores were significantly worse than nondepressed Hispanic/English, i.e., the impact of depression was less for Hispanic/Spanish women because both depressed and nondepressed women in this group reported worse outcomes. After adjustment for sociodemographic factors and depression, language remained significantly associated with outcomes.ConclusionDisparities in patient‐reported outcomes may be driven less by ethnicity than by sociodemographic or psychological factors. Measurement instruments that are not culturally appropriate and equivalent may also hamper meaningful analyses of disparities.
Catalytic Borylation using an Air‐Stable Zinc Boryl Reagent: Systematic Access to Elusive Acylboranes
Authors: Campos Jesús , Aldridge Simon 
Published: September 2015

AbstractThe use of borylzinc reagents in palladium‐catalyzed borylation chemistry is described (i.e. a boron analogue of the Negishi coupling), including a one‐pot bench‐top protocol using an air‐ and moisture‐stable bis(boryl)zinc reagent. The steric/electronic properties of the boryl fragment employed enable a systematic method for accessing acylboranes, a rare class of organoboron species with great potential in chemical synthesis. The reactions proceed under mild conditions, use inexpensive commercial sources of palladium, and demonstrate a remarkable functional‐group tolerance.
Femoral Condyle Curvature is Correlated with Knee Walking Kinematics in Ungulates
Authors: Sylvester Adam D. 
Published: September 2015

ABSTRACTThe knee has been the focus of many studies linking mammalian postcranial form with locomotor behaviors and animal ecology. A more difficult task has been linking joint morphology with joint kinematics during locomotor tasks. Joint curvature represents one opportunity to link postcranial morphology with walking kinematics because joint curvature develops in response to mechanical loading. As an initial examination of mammalian knee joint curvature, the curvature of the medial femoral condyle was measured on femora representing 11 ungulate species. The position of a region of low curvature was measured using a metric termed the “angle to low curvature”. This low‐curvature region is important because it provides the greatest contact area between femoral and tibial condyles. Kinematic knee angles during walking were derived from the literature and kinematic knee angles across the gait cycle were correlated with angle to low curvature values. The highest correlation between kinematic knee angle and the angle to low curvature metric occurred at 20% of the walking gait cycle. This early portion of the walking gait cycle is associated with a peak in the vertical ground reaction force for some mammals. The chondral modeling theory predicts that frequent and heavy loading of particular regions of a joint surface during ontogeny will result in these regions being flatter than the surrounding joint surface. The locations of flatter regions of the femoral condyles of ungulates, and their association with knee angles used during the early stance phase of walking provides support for the chondral modeling theory. Anat Rec, 298:2039–2050, 2015. © 2015 Wiley Periodicals, Inc.
Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1
Authors: Lemaire Raphaël , Burwell Timothy , Sun Hong , Delaney Tracy , Bakken Julie , Cheng Lily , Rebelatto Marlon C. , Czapiga Meggan , de‐Mendez Isabelle , Coyle Anthony J. , Herbst Ronald , Lafyatis Robert , Connor Jane 
Published: September 2015

ObjectiveSystemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation–fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI‐1) is the major inhibitor of profibrinolytic plasminogen activators (PAs). This study was undertaken to evaluate the contribution of PAI‐1 to SSc pathology in the skin.MethodsPAI‐1 was evaluated in skin from patients with diffuse SSc (dSSc) and those with limited SSc (lSSc) by immunohistochemistry. The contribution of PAI‐1 to SSc pathology was tested in vivo in murine graft‐versus‐host disease (GVHD) and bleomycin models of progressive skin fibrosis and in vitro in dermal human microvascular endothelial cells (HMVECs) using a monoclonal antibody that selectively prevents the binding of PAI‐1 to PA.ResultsSkin from patients with dSSc and those with lSSc showed increased PAI‐1 levels in the epidermis and microvessel endothelium. PAI‐1 neutralization in the GVHD model led to a dramatic, dose‐dependent improvement in clinical skin score, concomitant with vasculopathy resolution, including a reduction in fibrinolysis regulators and vascular injury markers, as well as reduced inflammation. Resolution of vasculopathy and inflammation was associated with resolution of skin fibrosis, as assessed by reduction in collagen content and expression of key profibrotic mediators, including transforming growth factor β1 and tissue inhibitor of metalloproteinases 1. Similar to the GVHD model, PAI‐1 neutralization reduced dermal inflammation and fibrosis in the bleomycin model. PAI‐1 neutralization stimulated plasmin‐mediated metalloproteinase 1 activation in dermal HMVECs.ConclusionOur findings indicate that neutralization of the antifibrinolytic function of PAI‐1 resolves skin fibrosis by limiting the extent of initial vascular injury and connective tissue inflammation. These data suggest that PAI‐1 represents an important checkpoint in disease pathology in human SSc.
Syncope and cardiac arrest during strenuous exercise associated with a novel mutation in LQTS1
Authors: Sandhu Amneet , Krantz Mori J. , Taylor Matthew , Aleong Ryan G. , Stichman Jennifer , Schuller Joseph L. 
Published: September 2015

Key Clinical MessageExercise‐induced syncope should alert clinicians to the possibility of LQTS and must be distinguished from other malignant causes of syncope such as hypertrophic cardiomyopathy, catecholaminergic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. Emerging genotype–phenotype links have connected mutations resulting in LQTS with risk of developing atrial fibrillation and cardiomyopathy.
Can stapedius reflex testing objectively measure muscle function in Pompe patients?
Authors: Hilz Max J. , Hoppe Ulrich , Moeller Sebastian , Wang Ruihao , Koehn Julia 
Published: September 2015

Key Clinical MessageWe assessed the value of stapedius reflex testing as an objective measurement of striated muscle function in four patients with Pompe disease. Common tests of disease severity and efficacy of enzyme replacement therapy (ERT) yield highly variable results that depend on patient cooperation and day‐to‐day performance, whereas stapedius reflex thresholds improved in seven of eight ears after 2 years of ERT.
Structural Studies on Porphyrin–PNA Conjugates in Parallel PNA:PNA Duplexes: Effect of Stacking Interactions on Helicity
Authors: Accetta Alessandro , Petrovic Ana G. , Marchelli Rosangela , Berova Nina , Corradini Roberto 
Published: September 2015

AbstractParallel PNA:PNA duplexes were synthesized and conjugated with meso‐tris(pyridyl)phenylporphyrin carboxylic acid at the N‐terminus. The introduction of one porphyrin unit was shown to affect slightly the stability of the PNA:PNA parallel duplex, whereas the presence of two porphyrin units at the same end resulted in a dramatic increase of the melting temperature, accompanied by hysteresis between melting and cooling curves. The circular dichroism (CD) profile of the Soret band and fluorescence quenching strongly support the occurrence of a face‐to‐face interaction between the two porphyrin units. Introduction of a L‐lysine residue at the C‐terminal of one strand of the parallel duplex induced a left‐handed helical structure in the PNA:PNA duplex if the latter contains only one or no porphyrin moiety. The left‐handed helicity was revealed by nucleobase CD profile at 240–280 nm and by the induced‐CD observed in the presence of the DiSC2(5) cyanine dye at ~500–550 nm. Surprisingly, the presence of two porphyrin units led to the disappearance of the nucleobase CD signal and the absence of CD exciton coupling within the Soret band region. In addition, a dramatic decrease of induced CD of DiSC2(5) was observed. These results are in agreement with a model where the porphyrin–porphyrin interactions cause partial loss of chirality of the PNA:PNA parallel duplex, forcing it to adopt a ladder‐like conformation. Chirality 27:864–874, 2015. © 2015 Wiley Periodicals, Inc.
Shortness of Breath During Pregnancy: Could a Cardiac Factor Be Involved?
Authors: Goland Sorel , Perelman Sharon , Asalih Nardin , Shimoni Sara , Walfish Osnat , Hallak Mordechai , Hagay Zion , George Jacob , Shotan Avraham , Blondheim David S. 
Published: September 2015

BackgroundShortness of breath (SOB) is common among healthy women with normal pregnancies. However, when no overt cardiac or extra cardiac etiology is found, a subtle cardiac source must be excluded.HypothesisPregnancy may induce or unmask myocardial dysfunction that may cause SOB.MethodsHealthy pregnant women with significant SOB were recruited for this study. We performed a comprehensive echocardiographic assessment including tissue Doppler imaging (TDI) and 2‐ dimensional strain imaging (2DS). The echocardiographic data obtained were compared with that of a control group of pregnant women without SOB.ResultsThirty pregnant women with SOB were enrolled in the study (age, 31.8 ± 4.9 years, and gestation, 38.2 ± 2.8 weeks) for whom no overt etiology for SOB was detected. Patients with SOB compared with controls had thicker hearts (septum: 10.1 ± 1.1 vs 8.9 ± 0.9 mm; P < 0.001; posterior wall: 9.4 ± 1.1 vs 8.9 ± 0.9 mm; P < 0.01), shorter E‐wave deceleration time (158.0 ± 50.1 vs 187.1 ± 37.6 msec; P = 0.01), and higher pulmonary artery pressure (26.8 ± 6.2 vs 19.0 ± 6.5 mm Hg, P < 0.01). Women with SOB tended to have a lower S' velocity TDI (P = 0.05) and a trend toward increased torsion on 2DS (P = 0.09).ConclusionsSignificant SOB during otherwise normal pregnancy is associated with significant echocardiographic findings that may suggest a subtle cardiac involvement. Further investigation is necessary to verify such an association, which may have therapeutic implications for treating SOB of pregnancy.
CD10, BCL6, and MUM1 expression in diffuse large B‐cell lymphoma on FNA samples
Authors: Cozzolino Immacolata , Varone Valeria , Picardi Marco , Baldi Carlo , Memoli Domenico , Ciancia Giuseppe , Selleri Carmine , De Rosa Gaetano , Vetrani Antonio , Zeppa Pio 
Published: September 2015

BACKGROUNDGene expression profiling has divided diffuse large B‐cell lymphoma (DLBCL) into 2 main subgroups: germinal center B (GCB) and non‐GCB type. This classification is reproducible by immunohistochemistry using specific antibodies such as CD10, B‐cell lymphoma 6 (BCL6), and multiple myeloma oncogene 1 (MUM1). Fine‐needle aspiration (FNA) plays an important role in the diagnosis of non‐Hodgkin lymphoma, and in some cases FNA may be the only available pathological specimen. The objectives of the current study were to evaluate CD10, BCL6, and MUM1 immunostaining on FNA samples by testing the CD10, BCL6, and MUM1 algorithm on both FNA cell blocks (CB) and conventional smears (CS), evaluating differences in CB and CS immunocytochemical (ICC) performance, and comparing results with histological data.METHODSThirty‐eight consecutive DLBCL cases diagnosed by FNA were studied. Additional passes were used to prepare CB in 22 cases and CS in 16 cases; the corresponding sections and smears were immunostained using CD10, BCL6, and MUM1 in all cases. The data obtained were compared with histological immunostaining in 24 cases.RESULTSICC was successful in 33 cases (18 CB and 15 CS) and not evaluable in 5 cases (4 CB and 1 CS). The CD10‐BCL6‐MUM1 algorithm subclassified DLBCL as GCB (9 cases) and non‐GCB (24 cases). ICC data were confirmed on histologic staining in 24 cases.CONCLUSIONSCD10, BCL6, and MUM1 ICC staining can be performed on FNA samples. The results herein prove it is reliable both on CB and CS, and is equally effective and comparable to immunohistochemistry data. Cancer (Cancer Cytopathol) 2016;124:135–143. © 2015 American Cancer Society.
Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis
Authors: Reid Michelle D. , Stallworth Christina R. , Lewis Melinda M. , Akkas Gizem , Memis Bahar , Basturk Olca , Adsay Volkan 
Published: September 2015

BACKGROUNDCytologic findings of pancreatic oncocytic‐type intraductal papillary mucinous neoplasms (IPMNs)/intraductal oncocytic papillary neoplasms (IOPNs) are largely unknown.METHODSFive IOPNs encountered by the authors were analyzed.RESULTSFour IOPNs were located in the pancreatic head, and 1 was located in the pancreatic body/tail in 2 men and 3 women ages 56 to 84 years (mean age, 66 years). Radiologic diagnoses included pancreatic ductal adenocarcinoma (PDAC) in 2 patients, invasive cancer associated with IPMN in 1 patient, IPMN versus mucinous cystic neoplasm in 1 patient, and cystic mass in 1 patient. Cytologic findings included: hypercellular smears (4 of 5 cases) containing well formed clusters of oncocytic cells (5 of 5 cases) with prominent, slightly eccentric nucleoli (4 of 5 cases), predominantly arranged in sheets/papillary units (5 of 5 cases), with punched‐out intercytoplasmic spaces (4 of 5 cases), and with occasional 3‐dimensional groups and focal necrosis (3 of 5 cases). The intracytoplasmic mucin and thick extracellular mucin typical of other IPMNs were observed only in 2 cases and were very limited. The mean size on resection was 4.5 cm. Invasion was observed in 3 cases (0.1, 0.3, and 2.0 cm) of tubular‐type IPMN. Initial cytologic evaluation was performed by the authors in 4 of 5 cases, which were diagnosed as IOPN (n = 3) and IPMN versus cystic PDAC (n = 1). One case was initially misdiagnosed as PDAC and, on resection, proved to be noninvasive IOPN.CONCLUSIONSCytologic features of IOPNs are classical, similar to their histologic counterparts, and differ significantly from other IPMN subtypes. Because of their highly complex appearance, they are often radiologically misdiagnosed as PDAC; thus, failure to recognize their characteristic features on fine‐needle aspiration may lead to inappropriate treatment. Patients with IOPN have an incomparably better prognosis than patients with ordinary PDAC, even when their neoplasms are invasive. Cancer (Cancer Cytopathol) 2016;124:122–134. © 2015 American Cancer Society.
Isotopic partitioning by small mammals in the subnivium
Authors: Calandra Ivan , Labonne Gaëlle , Mathieu Olivier , Henttonen Heikki , Lévêque Jean , Milloux Marie‐Jeanne , Renvoisé Élodie , Montuire Sophie , Navarro Nicolas 
Published: September 2015

AbstractIn the Arctic, food limitation is one of the driving factors behind small mammal population fluctuations. Active throughout the year, voles and lemmings (arvicoline rodents) are central prey in arctic food webs. Snow cover, however, makes the estimation of their winter diet challenging. We analyzed the isotopic composition of ever‐growing incisors from species of voles and lemmings in northern Finland trapped in the spring and autumn. We found that resources appear to be reasonably partitioned and largely congruent with phylogeny. Our results reveal that winter resource use can be inferred from the tooth isotopic composition of rodents sampled in the spring, when trapping can be conducted, and that resources appear to be partitioned via competition under the snow.