bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pediatric Case of Refractory Torsades de Pointes in Autoimmune Hypothyroidism
Authors: Chimatapu Sri Nikhita , Schachter Jessica L , Batra Anjan S , Sirignano Rachel , Okawa Erin R 
Published: July 2024

Abstract
Hypothyroidism can have a significant impact on cardiac contractility, vascular resistance, blood pressure, and cardiac rhythm. Ventricular arrhythmias induced by hypothyroidism are infrequently reported, especially in pediatric cases. A 15-year-old girl with autoimmune hypothyroidism experienced pulseless ventricular arrhythmias on 2 separate occasions because of nonadherence to levothyroxine medication. Subsequent investigations revealed an SCN5A mutation associated with Brugada syndrome. A loop recorder captured polymorphic ventricular tachycardia (PMVT), specifically Torsades de Pointes during her second event. Both arrhythmias were addressed only after stabilizing her thyroid hormone levels with replacement therapy. Although rare, patients with uncontrolled hypothyroidism may present with ventricular arrhythmias, particularly PMVT. The cornerstone of treatment for hypothyroidism-induced ventricular arrhythmia is thyroid replacement therapy. The identification of an SCN5A mutation unmasked by overt hypothyroidism emphasizes the need for a comprehensive cardiac evaluation in patients with hypothyroidism being assessed for PMVT.
Historical Patterns in the Intergenerational Transmission of Lifespan and Longevity: A Research Note on U.S. Cohorts Born Between 1700 and 1900
Authors: Minardi Saverio , Corti Giulia , Barban Nicola 
Published: July 2024

Abstract
This research note examines historical trends in lifespan inequality and the intergenerational transmission of lifespan and longevity in the United States over the eighteenth, nineteenth, and twentieth centuries. We contribute to the literature by expanding the estimates of the familial component beyond parent–child associations to include multigenerational and horizontal classes of relatives of different sexes. We also examine how lifespan inequality and the role of the family in lifespan and longevity changed over time. We address the challenge of studying extended family networks in historical times by leveraging recent online crowdsourced genealogical data. Results confirm the presence of a familial component for all classes of relatives considered and highlight a stronger association for horizontal than for vertical relationships. Despite decreasing lifespan inequality, we find no evidence of decreased familial lifespan stratification throughout history. If anything, the results suggest a strengthening of the parent–child association. Finally, the results contribute to the debate on the representativeness and usability of crowdsourced genealogical data by emphasizing the importance of sample selection based on the quality of the information collected.
Predictive Value of Bolster Supine X-Ray for the Correction of Segmental Deformity After Thoracolumbar Fusion Surgery
Authors: Lee Sang Hyub , Kim Dong-Hwan , Park Jin Hoon , Kang Dong Ho 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Assessment of thoracolumbar spine flexibility is crucial for determining which osteotomy to perform (posterior column osteotomy or 3-column osteotomy) to restore sagittal balance. Although preoperative bolster supine X-rays have been used to evaluate spine flexibility, their correlation with postoperative spinopelvic parameters has not been reported. We aimed to evaluate the predictive value of bolster X-ray for correcting sagittal deformities after thoracolumbar fusion surgery.

METHODS:
We retrospectively evaluated patients who underwent bolster supine radiography before posterior thoracolumbar fusion. Demographic data, operative records, and radiographic parameters were also recorded. The segmental Cobb angle, defined as the angle between the upper endplate of the uppermost and lower endplates of the lowest instrumented vertebrae, was compared between bolster and postoperative X-ray to evaluate the correlation between them. The predictive value of bolster X-ray for postoperative deformity correction was measured using intraclass correlation coefficients (ICC).

RESULTS:
Forty-two patients were included. The preoperative segmental Cobb angle (−1.4 ± 22.4) was significantly lower than the bolster segmental Cobb angle (23.2 ± 18.7, P < .001) and postoperative segmental Cobb angle (27.9 ± 22.3, P < .001); however, no significant difference was observed between the bolster and postoperative segmental Cobb angles (P = .746). Bolster X-ray showed a very strong correlation with postoperative X-ray (r = 0.950, P < .001) for segmental Cobb angle. Bolster supine X-ray had good-to-excellent reliability for postoperative X-ray with an ICC of 0.913 (95% CI, 0.760-0.962, P < .001) for the segmental Cobb angle.

CONCLUSION:
Bolster supine X-rays demonstrate good-to-excellent reliability with postoperative X-rays for segmental Cobb angles. These findings offer valuable insights into the selection of appropriate osteotomy techniques for clinical practice.
An International, Multicenter Feasibility Study on Active and Continuous Irrigation With Cerebrospinal Fluid Exchange for Improving Outcomes in Cerebral Ventriculitis
Authors: Baig Ammad A. , Hess Ryan M. , Sprau Annelise C. , Kemeny Hanna , Hashmi Eisa , Nazari Pouya , Lim Jaims , Turner Ryan C. , Brandmeir Nicholas , Rezai Jahromi Behnam , Niemelä Mika , Jahromi Babak S. , Levy Elad I. , Siddiqui Adnan H. 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Cerebral ventriculitis remains a challenging neurosurgical condition because of poor outcomes including mortality rates of nearly 80% and a prolonged course of treatment in survivors. Despite current conventional management, outcomes in some cases remain unsatisfactory, with no definitive therapeutic guidelines. This feasibility study aims to explore the use of a novel active, continuous irrigation and drainage system (IRRAflow [IRRAS AB]) combined with intraventricular drug delivery for patients with cerebral ventriculitis.

METHODS:
We conducted a multicenter, international, retrospective study of patients with ventriculitis who were treated with use of the IRRAflow system. Data collected included patient demographics, comorbidities, admission Glasgow Coma Scale score, baseline modified Rankin Scale (mRS) score, and imaging findings. Catheter occlusions, infections, and shunt placement were recorded for outcome assessment, along with discharge mRS scores and in-hospital deaths.

RESULTS:
Four centers contributed data for a total of 21 patients who had IRRAflow placement for treatment of ventriculitis. Thirteen (61.9%) were men (mean age = 49.8 ± 14.87 years). The median baseline mRS score was 1. The median Glasgow Coma Scale score at admission was 13. The etiology of ventriculitis was iatrogenic in 12 (57.1%) patients and secondary to an abscess in 9 (42.9%). No cases reported hemorrhage or failure of IRRAflow placement. Antibiotics were administered through the IRRAflow system in 13 (61.9%) cases in addition to systemic dosing. Sixteen (76.2%) patients had significant clinical improvement and resolution of ventriculitis. Seven (33.3%) patients required shunt placement after resolution because of persistent hydrocephalus. There were 6 (28.6%) in-hospital deaths.

CONCLUSION:
The use of active irrigation with drainage for continuous delivery of intraventricular irrigation fluid with antibiotics led to dramatically low mortality. In our case series, it led to a marked improvement in neurological status, imaging findings, and cerebrospinal fluid profiles, making it a technically feasible and safe treatment for ventriculitis.
Evolution of the regulation of developmental gene expression in blind Mexican cavefish
Authors: Leclercq Julien , Torres-Paz Jorge , Policarpo Maxime , Agnès François , Rétaux Sylvie 
Published: July 2024

ABSTRACT
Developmental evolution and diversification of morphology can arise through changes in the regulation of gene expression or protein-coding sequence. To unravel mechanisms underlying early developmental evolution in cavefish of the species Astyanax mexicanus, we compared transcriptomes of surface-dwelling and blind cave-adapted morphs at the end of gastrulation. Twenty percent of the transcriptome was differentially expressed. Allelic expression ratios in cave X surface hybrids showed that cis-regulatory changes are the quasi-exclusive contributors to inter-morph variations in gene expression. Among a list of 108 genes with change at the cis-regulatory level, we explored the control of expression of rx3, which is a master eye gene. We discovered that cellular rx3 levels are cis-regulated in a cell-autonomous manner, whereas rx3 domain size depends on non-autonomous Wnt and Bmp signalling. These results highlight how uncoupled mechanisms and regulatory modules control developmental gene expression and shape morphological changes. Finally, a transcriptome-wide search for fixed coding mutations and differential exon use suggested that variations in coding sequence have a minor contribution. Thus, during early embryogenesis, changes in gene expression regulation are the main drivers of cavefish developmental evolution.
A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration
Authors: Emmerich Kevin , Hageter John , Hoang Thanh , Lyu Pin , Sharrock Abigail V. , Ceisel Anneliese , Thierer James , Chunawala Zeeshaan , Nimmagadda Saumya , Palazzo Isabella , Matthews Frazer , Zhang Liyun , White David T. , Rodriguez Catalina , Graziano Gianna , Marcos Patrick , May Adam , Mulligan Tim , Reibman Barak , Saxena Meera T. , Ackerley David F. , Qian Jiang , Blackshaw Seth , Horstick Eric , Mumm Jeff S. 
Published: July 2024

ABSTRACT
Many genes are known to regulate retinal regeneration after widespread tissue damage. Conversely, genes controlling regeneration after limited cell loss, as per degenerative diseases, are undefined. As stem/progenitor cell responses scale to injury levels, understanding how the extent and specificity of cell loss impact regenerative processes is important. Here, transgenic zebrafish enabling selective retinal ganglion cell (RGC) ablation were used to identify genes that regulate RGC regeneration. A single cell multiomics-informed screen of 100 genes identified seven knockouts that inhibited and 11 that promoted RGC regeneration. Surprisingly, 35 out of 36 genes known and/or implicated as being required for regeneration after widespread retinal damage were not required for RGC regeneration. The loss of seven even enhanced regeneration kinetics, including the proneural factors neurog1, olig2 and ascl1a. Mechanistic analyses revealed that ascl1a disruption increased the propensity of progenitor cells to produce RGCs, i.e. increased ‘fate bias’. These data demonstrate plasticity in the mechanism through which Müller glia convert to a stem-like state and context specificity in how genes function during regeneration. Increased understanding of how the regeneration of disease-relevant cell types is specifically controlled will support the development of disease-tailored regenerative therapeutics.
Testing in Intermittent Sports—Importance for Training and Performance Optimization in Adult Athletes
Authors: VIGH-LARSEN JEPPE F. , JUNGE NICKLAS , CIALDELLA-KAM LYNN , TOMÁS RITA , YOUNG LAURA , KRUSTRUP PETER , MOHR MAGNI , NYBO LARS 
Published: July 2024

ABSTRACTPerformance in intermittent sports relies on the interplay between multiple physiological systems determining the capacity to perform short explosive efforts as well as repeated intense actions with limited recovery over the course of an entire game. Testing should reflect these demands to allow for sport- and position-specific capacity analyses that eventually may translate into optimized training and improved performance. This may include individual load management and optimized training prescription, intensity targeting for specific positions or individual athletes, as well as benchmarking for monitoring of training progression and enhanced engagement of athletes. This review provides an overview of available tests in different exercise domains identified as relevant (from assessment of single explosive actions to intermittent endurance capacity), forming the basis for recommendations on how to compose a comprehensive yet feasible test battery that may be integrated into the seasonal competition and training plan. The test procedures should cover the performance spectrum of relevance for the individual athlete—also in team sports to account for positional differences. We emphasize the benefits of sport-specific tests, highlight parameters of importance for test standardization, and discuss how the applied test battery may be supplemented with secondary tests directed toward specific energy systems to allow for more in-depth analyses when required (e.g., in terms of an underperforming athlete). The synergy between testing and tracking of match performance (utilizing time-motion or global positioning systems) is highlighted, and although tracking cannot substitute for testing, combining the tools may provide a comprehensive overview of the physiological demands and performance during competition contextualized to the athletes’ maximal exercise capacity.
Sowing seeds in decolonial cracks for pluriversity: reflections from arts–research co-productions on sustainability themes
Authors: Krauss Judith E. 
Published: July 2024

This article shares the author’s reflections on what decolonial cracks for recreating UK universities as sustainable pluriversities emerge from encounters and engagement in three arts–research co-productions relating to sustainability and justice: a training process led by a professional storyteller on converting political-ecology research into short, spoken ten-minute stories, the co-production of visual summaries and a role-playing game on sustainable value chains, and the collaboration producing an immersive audiovisual exhibition on ‘Can we fly-less?’.
This article makes an empirically based case that engaging in co-production on arts–research knowledge translation can help identify decolonial cracks to sow the seeds of pluriversity, that is, epistemically diverse institutions for public good that recognise present patterns of colonially rooted injustices and unsustainability, in UK academia. Drawing on relational, deep-listening conversations with six collaborators on the projects, three artists and three researchers, the article highlights benefits arising from the creative collaborations, such as social, transformative learning and critical introspection, and research acquiring a life beyond the page and becoming accessible to a broader audience. However, they also emphasised institutional barriers such as perverse incentives in current academic conventions, such as little or no recognition for knowledge translation, unequal starting points among permanent/precarious or salaried/non-salaried staff, and uncooperative monitoring and application systems, which render identifying these decolonial cracks and seeds necessary. With a methodology rooted in its conceptual, relational approach, the article highlights decolonial cracks in current academia, and transformative seeds to reimagine it in a more decolonial and sustainable image befitting of a pluriversity.
High-gain Ho:YLF sub-nanosecond system seeded by a gain-switched laser diode
Authors: Li Junhui , Yao Baoquan , Tang Jinwen , Wei Disheng , Cheng Wenhao , Zhang Runming , Duan Xiaoming , Dai Tongyv , Ju Youlun 
Published: July 2024

We demonstrate a high-gain Ho:YLF sub-nanosecond laser system utilizing a gain-switched laser diode as the seed source. The 1.0 kHz pJ-level seed from the gain-switched laser diode is first amplified to 1.1 mJ by a Ho-doped fiber preamplifier with a gain of 30 dB and a regenerative amplifier (RA) with a gain of 60 dB. By adding a single-pass amplifier, the pulse energy is further extended to 7.5 mJ. A pulse duration of 518.5 ps was achieved, which is symmetrical with no tail or sub-peaks. The root mean square (RMS) stability of the output energy of the entire system over a 0.5 h period is 2.11%. This method provides a reliable and simple way to directly obtain high-energy 2.05 µm sub-nanosecond lasers.
Widely tunable mid-infrared fiber-feedback optical parametric oscillator
Authors: Yu Tingting , Fang Jianan , Huang Kun , Zeng Heping 
Published: July 2024

Synchronously pumped optical parametric oscillators (OPOs) provide uniquely versatile platforms to generate ultrafast mid-infrared pulses within a spectral range beyond the access of conventional mode-locked lasers. However, conventional OPO sources based on bulk crystals have been plagued by complex optical alignment and large physical footprint. Here, we devise and implement two OPO variants based on a polarization-maintaining fiber-feedback cavity, which allow to robustly deliver sub-picosecond MIR pulses without the need of active stabilization. The first one integrates an erbium-doped fiber into the OPO cavity as the additional gain medium, which significantly reduces the pump threshold and allows stable optical pulse formation within a spectral range of 1553–1586 nm. The second one adopts a chirped poling nonlinear crystal in a passive-fiber cavity to further extend the operation spectral coverage, which facilitates broad tuning ranges of 1350–1768 nm and 2450–4450 nm for the signal and idler bands, respectively. Therefore, the presented mid-infrared OPO source is featured with high compactness, robust operation, and wide tunability, which would be attractive for subsequent applications such as infrared photonics, biomedical examination, and molecular spectroscopy.
An assessment of the value of deep neural networks in genetic risk prediction for surgically relevant outcomes
Authors: Christensen Mathias Aagaard , Sigurdsson Arnór , Bonde Alexander , Rasmussen Simon , Ostrowski Sisse R. , Nielsen Mads , Sillesen Martin 
Published: July 2024

Introduction
Postoperative complications affect up to 15% of surgical patients constituting a major part of the overall disease burden in a modern healthcare system. While several surgical risk calculators have been developed, none have so far been shown to decrease the associated mortality and morbidity. Combining deep neural networks and genomics with the already established clinical predictors may hold promise for improvement.

Methods
The UK Biobank was utilized to build linear and deep learning models for the prediction of surgery relevant outcomes. An initial GWAS for the relevant outcomes was initially conducted to select the Single Nucleotide Polymorphisms for inclusion in the models. Model performance was assessed with Receiver Operator Characteristics of the Area Under the Curve and optimum precision and recall. Feature importance was assessed with SHapley Additive exPlanations.

Results
Models were generated for atrial fibrillation, venous thromboembolism and pneumonia as genetics only, clinical features only and a combined model. For venous thromboembolism, the ROC-AUCs were 60.1% [59.6%-60.4%], 63.4% [63.2%-63.4%] and 66.6% [66.2%-66.9%] for the linear models and 51.5% [49.4%-53.4%], 63.2% [61.2%-65.0%] and 62.6% [60.7%-64.5%] for the deep learning SNP, clinical and combined models, respectively. For atrial fibrillation, the ROC-AUCs were 60.3% [60.0%-60.4%], 78.7% [78.7%-78.7%] and 80.0% [79.9%-80.0%] for the linear models and 59.4% [58.2%-60.9%], 78.8% [77.8%-79.8%] and 79.8% [78.8%-80.9%] for the deep learning SNP, clinical and combined models, respectively. For pneumonia, the ROC-AUCs were 50.1% [49.6%-50.6%], 69.2% [69.1%-69.2%] and 68.4% [68.0%-68.5%] for the linear models and 51.0% [49.7%-52.4%], 69.7% [.5%-70.8%] and 69.7% [68.6%-70.8%] for the deep learning SNP, clinical and combined models, respectively.

Conclusion
In this report we presented linear and deep learning predictive models for surgery relevant outcomes. Overall, predictability was similar between linear and deep learning models and inclusion of genetics seemed to improve accuracy.
Inflammatory profiles are associated with long COVID up to 6 months after COVID-19 onset: A prospective cohort study of individuals with mild to critical COVID-19
Authors: Wynberg Elke , Han Alvin X. , van Willigen Hugo D. G. , Verveen Anouk , van Pul Lisa , Maurer Irma , van Leeuwen Ester M. , van den Aardweg Joost G. , de Jong Menno D. , Nieuwkerk Pythia , Prins Maria , Kootstra Neeltje A. , de Bree Godelieve J. ,   on behalf of the RECoVERED Study Group
Published: July 2024

Background
After initial COVID-19, immune dysregulation may persist and drive post-acute sequelae of COVID-19 (PASC). We described longitudinal trajectories of cytokines in adults up to 6 months following SARS-CoV-2 infection and explored early predictors of PASC.

Methods
RECoVERED is a prospective cohort of individuals with laboratory-confirmed SARS-CoV-2 infection between May 2020 and June 2021 in Amsterdam, the Netherlands. Serum was collected at weeks 4, 12 and 24 of follow-up. Monthly symptom questionnaires were completed from month 2 after COVID-19 onset onwards; lung diffusion capacity (DLCO) was tested at 6 months. Cytokine concentrations were analysed by human magnetic Luminex screening assay. We used a linear mixed-effects model to study log-concentrations of cytokines over time, assessing their association with socio-demographic and clinical characteristics that were included in the model as fixed effects.

Results
186/349 (53%) participants had ≥2 serum samples and were included in current analyses. Of these, 101/186 (54%: 45/101[45%] female, median age 55 years [IQR = 45–64]) reported PASC at 12 and 24 weeks after COVID-19 onset. We included 37 reference samples (17/37[46%] female, median age 49 years [IQR = 40–56]). In a multivariate model, PASC was associated with raised CRP and abnormal diffusion capacity with raised IL10, IL17, IL6, IP10 and TNFα at 24 weeks. Early (0–4 week) IL-1β and BMI at COVID-19 onset were predictive of PASC at 24 weeks.

Conclusions
Our findings indicate that immune dysregulation plays an important role in PASC pathogenesis, especially among individuals with reduced pulmonary function. Early IL-1β shows promise as a predictor of PASC.
Esophageal Lichen Planus: The Efficacy and Safety of Tacrolimus in Reducing Inflammation and Need for Dilation
Authors: Kukreja Keshav , Kumar Ambuj , Camisa Charles , Jacobs John , Richter Joel E. 
Published: July 2024

INTRODUCTION:
Esophageal lichen planus (ELP) is a rare inflammatory disease most seen in middle-aged White women, manifested by sloughing mucosa, thick exudate, and proximal strictures. Most case reports and small series highlight using steroids and other immunosuppressants. To the best of our knowledge, oral tablet tacrolimus has not been studied. We aimed to assess the change in ELP after oral tacrolimus treatment.

METHODS:
The primary outcome was the efficacy of tacrolimus objectively through our scoring system, ELP Severity Score (ELPSS). All consecutive adults with ELP who underwent more than one esophagogastroduodenoscopy by 2 esophagologists and being treated with tacrolimus or other treatment were eligible for inclusion in this retrospective cohort study. Inflammation and fibrostenotic disease were graded using the novel ELPSS.

RESULTS:
Twenty-two patients met the inclusion criteria. Half (11) received tacrolimus (dose 1–2 mg twice daily), and half (11) received other therapy (i.e., cyclosporine, topical steroids, or none). Mean ELPSS on the first esophagogastroduodenoscopy, extraesophageal manifestations of disease, presenting symptoms, and baseline characteristics were similar between groups. Among patients on Tac vs No-Tac, there was a statistically significant improvement in ELPSS (mean difference 1.8 pts; 95% confidence interval 0.25–3.38; P = 0.02). Response rate was 89% with Tac vs 30% with No-Tac (P = 0.025). All 22 patients underwent bougie dilation safely with a mean diameter of 16 mm achieved. Patients on Tac also required less frequent dilation.

DISCUSSION:
Oral tablet tacrolimus reduced the inflammatory and fibrostenotic components of ELP. Thus, low-dose oral tacrolimus is safe and should be considered in patients with more severe disease.