bluuebunny/crossref_metadata_2025_split huggingface dataset:
PIONEER REAL Japan: Primary results from a multicenter, prospective, real‐world study of oral semaglutide in adults with type 2 diabetes in Japanese clinical practice
Authors: Yabe Daisuke , Hamamoto Yoshiyuki , Kawanami Daiji , Nishimura Rimei , Terauchi Yasuo , Amadid Hanan , Braae Uffe Christian , Major‐Pedersen Atheline , Suzuki Ryo 
Published: August 2024

ABSTRACTAims/IntroductionPIONEER REAL Japan was a non‐interventional prospective study of oral semaglutide in adults with type 2 diabetes in Japanese clinical practice.Materials and MethodsAdults naïve to injectable glucose‐lowering therapies initiated oral semaglutide in routine clinical practice and were followed for 34–44 weeks. The primary endpoint was change in glycated hemoglobin (HbA1c) from baseline to end of study; the co‐primary endpoint was number of adverse events (AEs). Secondary endpoints included change in bodyweight from baseline to end of study. Analyses were also carried out for subgroups aged <75 and ≥75 years.ResultsA total of 624 participants initiated oral semaglutide; 578 completed the study. Mean baseline HbA1c and bodyweight were 7.7% and 72.4 kg, respectively. At end of study, estimated change (95% confidence interval [CI]) in HbA1c from baseline was −0.7 percentage points (−0.77, −0.61) overall, −0.8 percentage points (−0.86, −0.67) in the <75 years subgroup and −0.5 percentage points (−0.68, −0.41) in the ≥75 years subgroup (all P < 0.0001). Estimated change (95% CI) in bodyweight was −2.8 (−3.19, −2.50) kg overall, −2.9 (−3.38, −2.49) kg in the <75 years subgroup and − 2.7 (−3.18, −2.14) kg in the ≥75 years subgroup (all P < 0.0001). AEs occurred in 161 (25.8%) participants: 99 of 423 (23.4%) and 62 of 201 (30.8%) participants in the <75 and ≥75 years subgroups, respectively. Gastrointestinal AEs were the AEs most frequently leading to oral semaglutide discontinuation.ConclusionsIn routine clinical practice, HbA1c and bodyweight were significantly reduced from baseline in adults initiating oral semaglutide, including those aged ≥75 years, with no new safety concerns.
Calpeptin improves the cognitive function in Alzheimer's disease‐like complications of diabetes mellitus rats by regulating TXNIP/NLRP3 inflammasome
Authors: Qiao Luyao , Yi Shouqin , Li Tianpei , Pan Xin , Wang Gege , Liu Xu , Li Min , Min Jun , Le Huahui , Tang Zhenyu 
Published: August 2024

ABSTRACTAimsDiabetes mellitus (DM) is closely associated with Alzheimer's disease (AD), and is considered an accelerator of AD. Our previous study has confirmed that the Calpain inhibitor Calpeptin may alleviate AD‐like complications of diabetes mellitus. This work further investigated its underlying mechanism.Materials and MethodsDiabetes mellitus rat model was constructed by a high‐fat and high‐sugar diet combined with streptozotocin, followed by the administration of Calpeptin. Moreover, rats were micro‐injected with LV‐TXNIP‐OE/vector into the CA1 region of the hippocampus one day before streptozotocin injection. The Morris water maze test assessed the spatial learning and memory ability of rats. Immunohistochemistry and western blotting detected the expression of the pericyte marker PDGFRβ, tight junction proteins occludin and ZO‐1, calpain‐1, calpain‐2, APP, Aβ, Aβ‐related, and TXNIP/NLRP3 inflammasome‐related proteins. Immunofluorescence staining examined the blood vessel density and neurons in the hippocampus. Evans blue extravasation and fluorescence detected the permeability of the blood–brain barrier (BBB) in rats. Additionally, the oxidative stress markers and inflammatory‐related factors were assessed by enzyme‐linked immunosorbent assay.ResultsCalpeptin effectively reduced the expression of Calpain‐2 and TXNIP/NLRP3 inflammasome‐related proteins, improved the decreased pericyte marker (PDGFR‐β) and cognitive impairment in hippocampus of DM rats. The neuronal loss, microvessel density, permeability of BBB, Aβ accumulation, inflammation, and oxidative stress injury in the hippocampus of DM rats were also partly rescued by calpeptin treatment. The influence conferred by calpeptin treatment was reversed by TXNIP overexpression.ConclusionsThese data demonstrated that calpeptin treatment alleviated AD‐like symptoms in DM rats through regulating TXNIP/NLRP3 inflammasome. Thus, calpeptin may be a potential drug to treat AD‐like complications of diabetes mellitus.
Development and performance evaluation of a portable solar‐assisted evaporative cool chamber for preservation of perishables
Authors: Patel Deep P. , Jain S. K. 
Published: August 2024

AbstractHorticulture plays a pivotal role in providing livelihoods, nutrition, and economic growth. However, post‐harvest losses due to inadequate storage facilities and practices remain a significant issue. The storage of horticultural produce involves developing and adopting sustainable, cost‐effective solutions tailored to the unique challenges of resource‐constrained environments. Despite the availability of refrigeration and cold storage facilities, their energy‐intensive and expensive nature renders them inaccessible to many. To tackle this problem, a solar‐assisted evaporative cool chamber (ECC) with a storage capacity of 250 kg was designed. It is powered by a 200 W solar panel, a 150 Ah battery with a charge controller, a 9 W water pump, and two 7.4 W exhaust fans. Extensive performance evaluation optimized water flow rates, air velocities, and pad materials, leading to a significant temperature drop of 14.9°C and a 64.3% humidity increase with 98.48% saturation efficiency, achieved with a water flow rate (6 L/min), air velocity (4 m/s), and honeycomb pad material. The inclusion of a thermoelectric Peltier module further lowered the temperature to 17.0°C and raised humidity to 70.1% within the ECC. Storage studies with four fruits (bananas, apples, papayas, and oranges) and four vegetables (tomatoes, okras, brinjals, and cucumbers) demonstrated that products stored inside the ECC remained marketable for an additional 4–15 days, nearly doubling their shelf life compared with ambient conditions. An economically viable ECC solution effectively addresses the needs of hot climate regions, providing a valuable solution for post‐harvest preservation.Practical applicationsHorticulture is crucial for livelihoods, nutrition, and economic growth that face challenges in post‐harvest losses due to inadequate storage facilities. Traditional refrigeration solutions are often inaccessible in resource‐constrained environments. To address this, a solar‐assisted evaporative cool chamber (ECC) with a 250 kg storage capacity was designed and evaluated for performance. The solar‐assisted ECC presents a practical and cost‐effective technology with the potential to significantly improve post‐harvest management, empower small‐scale farmers, and promote sustainable food systems, particularly in resource‐constrained environments.
It got me thinking: The impact of participating in a divorce decision‐making interview
Authors: Fenske Shauna R. , Harris Steven M. , LaPlant‐Braughton Jacqueline , Allen Sarah , Roberts Kelly , Anderson Grace 
Published: August 2024

AbstractAlthough there is literature documenting the reasons for and outcomes of divorce, there is limited research about the divorce decision‐making process. Researchers with the National Divorce Decision‐Making Project interviewed (n = 30) people in the process of making a divorce decision. One year later they conducted a second interview (n = 22) with the same sample to track any changes in participants' divorce ideation. The current study reports on the results of a thematic analysis of participants' responses to the final question, “How did the initial interview impact your thinking about the future of your marriage?” Three salient themes emerged from the data: (1) talking got me thinking, (2) thinking got me acting, and (3) the conversation was (surprisingly) therapeutic. The authors highlight possible clinical implications and directions for future research.
Novel injectable polypeptide nanoparticle encapsulated siRNA targeting TGF‐β1 and COX‐2 for localized fat reduction I: Preclinical in vitro and animal models
Authors: Nestor Mark S. , Hetzel John , Awad Nardin , Bhupalam Vishnu , Lu Patrick , Molyneaux Michael 
Published: August 2024

AbstractBackgroundObesity and localized fat accumulation continue to drive the demand for minimally invasive body contouring technologies including injectable compounds for local fat reduction. siRNA offers a potential for an injectable to specifically target and silence genes involved in adipogenesis with minimal inflammatory side effects.AimsThis study evaluates the efficacy of STP705, an injectable containing siRNA encapsulated within histidine‐lysine polypeptide (HKP) nanoparticles targeting transforming growth factor β1 (TGF‐β1) and cyclooxygenase‐2 (COX‐2), crucial mediators in adipocyte differentiation and fat retention, using in vitro, porcine, and murine models.MethodsIn vitro experiments on mouse preadipocytes and in vivo trials using Diet Induced Obese (DIO) mice and Yucatan minipigs were conducted to assess the gene silencing efficiency, tissue localization, pharmacodynamics, and safety profile of STP705.ResultsSTP705 effectively reduced the expression of TGF‐β1 and COX‐2, with a notable decrease in adipocyte volume and lipid content without adverse systemic effects. In DIO mice, the HKP‐siRNA complex demonstrated precise localization to injected adipose tissue, maintaining significant gene silencing, and detectable levels of siRNA for up to 14 days post‐administration. Similar results in minipigs showed a significant reduction in subcutaneous adipose tissue thickness.ConclusionThe results of these studies support the use of targeted siRNA therapy specifically targeting TGF‐β1 and COX‐2, for localized fat reduction, offering a potential minimally invasive alternative to current fat reduction methods.
Comparative Bibliometric Analysis of Established and Emerging Databases on Salivary Biomarkers for Early Oral Cancer Diagnosis
Authors: Pradhan Pragya , Saxena Vrinda , Haider Aiman 
Published: August 2024

ABSTRACTBackgroundSalivary biomarkers play an important role in the preventive strategy for oral cancer detection at an early stage. The aim of this study was to carry out a comparative quantitative analysis of the research material on the topic in one established database, Scopus and another emerging database, Dimensions.MethodAn electronic search was performed in Scopus and Dimensions in April 2024 with the search subjects “Saliva,” “Biomarkers,” “Diagnosis,” and “Oral Cancer.” The retrieved data were analyzed using Biblioshiny for RStudio and MS Excel.ResultThe search yielded 229 and 158 documents in Scopus and Dimensions, respectively. The data were studied to understand the coverage, concentration, and diversion of research articles. The analysis revealed high singularity index for Scopus and low overlap percentage between the two databases. Scopus was found to have higher citation count per article, however, the citation correlation between Scopus and Dimensions was found to be strong. Author productivity was found to be low in both the databases.ConclusionScopus and Dimensions vary in their scope, volume of data, and coverage policies. Both the databases have complimentary coverage on salivary biomarkers for oral cancer diagnosis. However, Scopus has a greater number of articles, sources, and citations resulting in better coverage of the topic.
We're not in dreamland anymore: The consequences of community opioid use on local industrial composition
Authors: Langford W. Scott , Feldman Maryann P. 
Published: August 2024

AbstractWe estimate the effect of opioid use rates on local economic resilience through changes in industrial composition. We find regional opioid use rates adversely affect firm growth in general, with the greatest impact on small firms. Our results are robust to several identification strategies (Difference in Differences, Propensity Score Matching, and Instrumental Variables) and alternative empirical specifications. Our findings establish that local industrial composition and long‐term resilience are each adversely affected by the opioid public health crisis.
Covid‐19 and its effect on formal employment in Mexico: Are there signs of recovery?
Authors: Martínez‐Martínez Oscar A. , Reyes‐Martínez Javier 
Published: August 2024

AbstractThe conditions of the Mexican labor market during the Covid‐19 pandemic went through different stages. The government first declared a quarantine that lasted for several months, the effects of which continue to be quantified. In that sense, this article answers two questions, (1) what are the changes in labor formality rates before and 2 years after the Covid‐19 pandemic began in Mexico?; and (2) are there differences in economic sectors and between genders? We use the methodology proposed by Chacaltana and McMillan to measure the variation in the labor formality rate in its two components, (1) intrasectoral; and (2) intersectoral, through 9 quarterly editions of the National Occupation and Employment Survey. The results show that in the first 2 years of the pandemic and especially during the time of confinement, labor informality was not a means to maintain household income, as had happened in other economic crises. Likewise, important sectoral effects were found, with the most affected industries being nonessential ones. Finally, gender gaps widened, with women being the most affected in the formal and informal labor market due to pre‐existing conditions that were aggravated by the pandemic.
Effect of growth trajectories in communication skills on juvenile recidivism
Authors: Liu Lin 
Published: August 2024

AbstractPurposeIncreasing numbers of children with behaviour problems in school are recognized as having language and communication difficulties. However, communication limitations have not been assessed adequately as a risk factor for juvenile recidivism. The aim of this study was to examine how changes in communication skills impacted subsequent engagement in crime among youth.MethodsFour waves of longitudinal data of youth who were placed in juvenile justice residential facilities were used for the study. Group‐based trajectory and multivariate regression analyses were used to investigate how the growth trajectories of communication skills impacted recidivism.ResultsGroup‐based trajectory analysis revealed heterogeneous growth in communication skills among residential youth. More interestingly, the scale of growth predicted recidivism.ConclusionsThis study extends an understanding of juvenile aggression and criminal offences by underlining communication limitation issues as a focal predictor of recidivism. Sufficient resources are needed for the development, evaluation and implementation of intervention programmes to help youth overcome limitations in communication.
Different Measures of Hyperglycemia Are Negatively Associated With Skin Microvascular Flowmotion: The Maastricht Study
Authors: Zhao X. , Schalkwijk C. , Kroon A. , Schram M. T. , Stehouwer C. , Houben A. 
Published: August 2024

ABSTRACTObjectiveDiabetes can lead to microvascular complications such as diabetic neuropathy, nephropathy, and retinopathy. Hyperglycemia may initiate microvascular function impairment early in the course of diabetes, even prior to its clinical establishment during the pre‐diabetes stage. Microvascular vasomotion, that is, the rhythmic arteriolar constriction and dilation, is an important function that regulates oxygen and nutrient delivery within the tissue and regulates peripheral resistance. Using laser Doppler flowmetry (LDF), vasomotion in skin microcirculation can be measured as flowmotion. Changes in flowmotion have been shown in individuals with obesity, and type 1 or type 2 diabetes mellitus. However, no data are available on associations between hyperglycemia and flowmotion in the general population. Our aim was to study whether measures of hyperglycemia were associated with different components of skin microvascular flowmotion (SMF) in a population‐based cohort (The Maastricht Study).MethodsData from 7293 participants of The Maastricht Study were used. SMF was measured using LDF. Endothelial, neurogenic and myogenic component SMF power were used as dependent variables. We investigated the associations of glucose metabolism status (normal glucose metabolism, prediabetes, and type 2 diabetes mellitus), measures of hyperglycemia (fasting plasma glucose [FPG], 2‐h post‐load glucose [2 h‐PG], HbA1c, advanced glycation end‐products [AGEs] assessed as skin autofluorescence [SAF]), and indices of glucose variability (incremental glucose peak [IGP] and continuous glucose monitoring [CGM] ‐assessed as standard deviation [SD]) with each component of SMF power. We used linear regression analyses with adjustments for confounders, and trend analyses.ResultsWe observed consistent negative associations between HbA1c levels and all three (endothelial, neurogenic, and myogenic) skin microvascular flowmotion (SMF) powers in the additionally adjusted model. Similarly, in the conservative model, we found that multiple hyperglycemia metrics such as GMS trend, PreD, T2DM, FPG, 2 h‐PG, and HbA1c were consistently negatively associated with all three SMF powers.ConclusionsWe showed that skin microvascular flowmotion is reduced in individuals with (pre)diabetes. In addition, different measures of hyperglycemia are negatively associated with skin microvascular flowmotion.
Providing biological context for GWAS results using eQTL regulatory and co‐expression networks in Populus
Authors: Shu Mengjun , Yates Timothy B. , John Cai , Harman‐Ware Anne E. , Happs Renee M. , Bryant Nathan , Jawdy Sara S. , Ragauskas Arthur J. , Tuskan Gerald A. , Muchero Wellington , Chen Jin‐Gui 
Published: August 2024

Summary

Our study utilized genome‐wide association studies (GWAS) to link nucleotide variants to traits in Populus trichocarpa, a species with rapid linkage disequilibrium decay. The aim was to overcome the challenge of interpreting statistical associations at individual loci without sufficient biological context, which often leads to reliance solely on gene annotations from unrelated model organisms.

We employed an integrative approach that included GWAS targeting multiple traits using three individual techniques for lignocellulose phenotyping, expression quantitative trait loci (eQTL) analysis to construct transcriptional regulatory networks around each candidate locus and co‐expression analysis to provide biological context for these networks, using lignocellulose biosynthesis in Populus trichocarpa as a case study.

The research identified three candidate genes potentially involved in lignocellulose formation, including one previously recognized gene (Potri.005G116800/VND1, a critical regulator of secondary cell wall formation) and two genes (Potri.012G130000/AtSAP9 and Potri.004G202900/BIC1) with newly identified putative roles in lignocellulose biosynthesis.

Our integrative approach offers a framework for providing biological context to loci associated with trait variation, facilitating the discovery of new genes and regulatory networks.
Reframing covenant for nursing: From individual commitments to covenant with society
Authors: Wolfs Dorolen , Jantzen Darlaine , Fowler Marsha , Musto Lynn C. , Reimer‐Kirkham Sheryl 
Published: August 2024

AbstractToday's constrained healthcare environment can make it very difficult for nurses to provide compassionate, competent, and ethical care, and yet their continued commitment to care is viewed as requisite. Nurses' commitment to care of patients, enmeshed with professional identity, may be understood as heroic. A few nursing scholars have advanced the concept of a nurse‐patient covenant to explain or inspire nurses' commitment to care. Covenant describes an enduring relationship characterised by mutual promises and generous responsiveness. However, recent critique has revealed a general misunderstanding and misuse of the term covenant in much of the nursing literature whereby individual nurses are improperly and impossibly idealised as holding sole responsibility in the commitment to care. Such an interpretation obscures society's responsibilities in caring for both patients and nurses and contributes to the idealisation of nurses' commitment to extend themselves to fill in healthcare system gaps. Yet, the concept of a covenant relationship, when reframed as occurring between society and the profession of nursing, may lead us toward solutions to the very problems the originally misused concept sustained. Evidence within healthcare systems globally suggests that nurses' commitments are fragile or fragmented under duress due to increasing pressure, demands, and even risks. A reframing of covenant has the common good for society and nursing at its core and, we argue, may lead to a more sustainable nursing identity. We present the results of an exploratory project, undertaken to examine the utility and suitability of covenant as a relational framework for nursing. We explore a reframing of a covenant of care as a relationship between nursing and society, which may provide a fruitful path toward a sustainable, shared commitment for healthcare. This covenant of care re‐centres shared work—a joint responsibility between society and nursing—as necessary for the common good.
Reimagining a nursing ecosystem in an uncertain world
Authors: Krol Pawel , Einboden Rochelle , Wong Horas , Geia Lynore , Tembo Agness 
Published: August 2024

AbstractThe discussion paper synthesises the insights shared during a keynote panel at the 26th International Philosophy of Nursing Conference, themed “Reimagining a nursing ecosystem in an uncertain world.” It delves into the substantial impact uncertainty has on nursing, offering innovative strategies for reconceptualization. Through a critical examination of evidence‐based practice, the tendency to homogenise nursing is discussed, prompting advocacy for a Nietzschean political framework as a form of resistance and emancipation. Drawing inspiration from Donna Haraway, a transition from individualistic to relational approaches is needed, especially amidst social and economic instability. Furthermore, the integration of caritas and Indigenous epistemologies underscore the significance of cultural sensitivity in nursing. Meanwhile, Ubuntu philosophy champions empathy and collective values, while a convergence of Eastern and Western philosophical traditions promises to enrich nursing practice. Ultimately, the panellists advocate for overcoming rigid ideologies in favour of a pluralistic approaches, ontologies, epistemologies and ethics to address contemporary challenges, and signal for a philosophical reorientation to engage uncertainty and reshape nursing roles in an ever‐evolving and world.
Expert Consensus on an Open‐Access UNIMMAP MMS Product Specification: 2024 revision
Authors: Ajello Clayton A. , Atwater John , de Lange Jarno 
Published: August 2024

AbstractThe United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) of a multiple micronutrient supplement (MMS) for pregnant women is a proven evidence‐based nutrition intervention and is listed on the World Health Organization (WHO) Model List of Essential Medicines. The 2024 revision of the Expert Consensus on an Open‐Access UNIMMAP MMS Product Specification provides both purchasers and manufacturers with unified guidance on the production of UNIMMAP MMS. More specifically, it outlines the minimum requirements for the manufacture of UNIMMAP MMS and provides guidance on quality and regulatory standards based on whether the product is manufactured as a medicinal product or a dietary supplement. The product specification includes ingredients, excipients/food additives, and processing aids used in manufacturing UNIMMAP MMS; stability testing for different climatic zones; packaging and labeling considerations; pharmacopeial standards, manufacturing practices, certificates of analysis, change control, and quality agreement; finished product test specifications, including tablet characterization and purity/strength assay; analytical test methods; and storage and transportation requirements.