bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Prediction and Control of Discrete‐Time First‐Order Linear Stochastic Systems with Prospective Strong Intervention
Authors: Gai Rudong 
Published: February 2014

AbstractThis paper is devoted to studying the issue of modeling, forecasting, and optimal feedback control of discrete‐time first‐order linear stochastic systems with prospective strong intervention (PSI). First, one type of PSI is formulated. Then, one class of induced mechanisms of PSI is characterized, and, with respect to the induced mechanisms, two multi‐step forecasting methods for estimating the occurrence time and terminal time of PSI are discussed. Based on these fundamental results, the problem of optimal control with respect to an improved minimum variance performance index is discussed. Finally, the effectiveness and advantages of the proposed control strategy and approach are verified and demonstrated through numerical simulations.
President's page
Authors: Bruce Harry 
Published: February 2014

AbstractEDITOR'S SUMMARYASIS&T President Harry Bruce expresses joy and thanks for volunteers' contributions to the Association, pointing out advantages and challenges of a governance structure largely dependent on volunteer activity. Significant recent developments by volunteer committees include the Web Presence Task Force's recommendations for the ASIS&T website redesign, progressing to the RFP stage. The Membership Committee and International Relations Committee are working to strengthen and expand membership, attracting more global members and transitioning students to professional membership. Bruce envisions ASIS&T as the premier association for both information professionals and information scholars and points out the work of the Information Professionals Task Force to identify the many professional roles in the information industry. The Membership Committee will build on its work by encouraging current members to promote the value of membership for information professionals.
ASIS&T annual meeting award winners: Award of merit acceptance speech
Authors: Kuhlthau Carol Collier 
Published: February 2014

AbstractEDITOR'S SUMMARYAs the recipient of ASIS&T's Award of Merit, Carol Collier Kuhlthau expressed appreciation for the association's influence on her scholarly development. Kuhlthau recounted the field's expansion and evolution from library school studies to information science, communication and social construction. Her focus on the information search process has been driven by questions about purpose in information seeking, user experience and affect. Her research into information seeking in learning has led pragmatically to Guided Inquiry, an educational design framework based on the scholar's research into the information search process. Highlighting information as central to people's everyday lives, Kuhlthau urged information scientists to focus on the practical implications of their work and how their research can be broadly applied to improve society.
Educating researchers for effective data management
Authors: Eaker Christopher 
Published: February 2014

AbstractEDITOR'S SUMMARYAttaining the goal of long‐term, open access to research data requires consistent data management, ideally by contributing scholars. Of several programs available to present data management instruction, three are described, compared and contrasted for use by graduate students. The collaborative product of six institutions, the New England Collaborative Data Management Curriculum includes an overview and six additional modules. Based on case studies, it features a flexible delivery method and timeframe. The DataONE Data Management Education Modules cover comparable topics in greater depth. Like the others, the University of Edinburgh's MANTRA is modular. It offers different perspectives based on roles and provides quizzes and additional resources. Each of the programs can be used for self‐paced training, adapted to a one‐day workshop or spread over a semester. Research institutions should consider customizing a program for their specific needs and researcher skills.
Complex patients treated with zotarolimus‐eluting resolute and everolimus‐eluting xience V stents in the randomized TWENTE trial: Comparison of 2‐year clinical outcome
Authors: Sen Hanim , Lam Ming Kai , Tandjung Kenneth , Löwik Marije M. , Stoel Martin G. , de Man Frits H.A.F. , Louwerenburg J. (Hans) W. , van Houwelingen Gert K. , Linssen Gerard C.M. , Doggen Carine J.M. , Basalus Mounir W.Z. , von Birgelen Clemens 
Published: February 2014

ObjectiveTo assess the differences in clinical outcome between complex patients treated with Resolute zotarolimus‐eluting stents (ZES) versus Xience V everolimus‐eluting stents (EES).BackgroundNowadays, many complex patients with coronary disease are treated with percutaneous coronary interventions, using drug‐eluting stents (DES).MethodsWe analyzed 2‐year outcome data of 1,033 complex patients of the TWENTE trial, treated with second‐generation Resolute ZES or Xience V EES. Complex patients had at least one of the following characteristics: renal insufficiency (creatinine ≥ 140 µmol/l); ejection fraction < 30%; acute myocardial infarction (MI) within previous 72 hrs; >1 lesion/vessel; >2 vessels treated; lesion length > 27 mm; bifurcation; saphenous vein graft lesion; arterial bypass graft lesion; in‐stent restenosis; unprotected left main lesion; lesion with thrombus; or lesion with total occlusion. Target vessel failure (TVF), the primary composite endpoint of the trial, was defined as cardiac death, target vessel‐related MI, or target vessel revascularization.ResultsAmong the 1,033 complex patients, 529 (51%) were treated with Resolute ZES and 504 (49%) with Xience V EES. Patient‐ and procedure‐related characteristics were similar between DES groups. After 2‐year follow‐up, outcome was also similar between DES groups. TVF occurred in 12.1% of patients treated with Resolute ZES and 12.3% of patients treated with Xience V EES. In addition, DES groups did not differ significantly in cardiac death, MI, or target vessel revascularization—the individual components of TVF.ConclusionComplex patients treated with Resolute ZES and Xience V EES showed similar safety and efficacy during 2‐year follow‐up. © 2014 Wiley Periodicals, Inc.
Safety and long‐term outcomes after percutaneous coronary intervention in patients with human immunodeficiency virus
Authors: Badr Salem , Minha Sa'ar , Kitabata Hironori , Fatemi Omid , Torguson Rebecca , Suddath William O. , Satler Lowell F. , Pichard Augusto D. , Waksman Ron 
Published: February 2014

ObjectiveThis study aims to report the long‐term outcomes after percutaneous coronary intervention (PCI) in human immunodeficiency virus (HIV+) patients.BackgroundSparse data exists regarding the risk of patients with HIV who undergo PCI.MethodsUsing a case‐control design, we compared baseline characteristics, procedure‐related outcomes, in‐hospital, and 2‐year clinical outcomes of 112 consecutive HIV+ patients versus 112 HIV‐ controls matched for age, gender, and diabetes mellitus who underwent PCI from April 2003 to September 2011.ResultsBaseline characteristics were generally comparable, save for more African Americans and history of chronic renal insufficiency in the HIV+ vs. HIV‐ group (62.5% vs. 21.4%, P < 0.001) and (27.7% vs. 9.9%, P < 0.001). There was no correlation between CD4 nadir count and extent and diffuseness of coronary artery disease. The occurrence of major adverse cardiac events at 2 years was similar in both groups. Multivariable analysis for independent correlates of major adverse cardiac events at 2 years detected patients with a history of chronic renal insufficiency (OR: 2.44, 95% confidence interval: 1.02–5.83; P = 0.04) and acute myocardial infarction (OR: 2.92, 95% confidence interval: 1.39–6.15; P = 0.005) as correlates for outcome. Post‐hoc analysis showed that drug‐eluting stent (DES) use in the HIV+ group was beneficial.ConclusionPCI in HIV+ patients is safe, with high procedural success rates, and produces similar outcomes to those seen in HIV‐ patients at 2 years. HIV+ patients should be treated with DES if possible. © 2014 Wiley Periodicals, Inc.
Standardizing radiation dose reporting in the pediatric cardiac catheterization laboratory—A multicenter study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)
Authors: Kobayashi Daisuke , Meadows Jeffery , Forbes Thomas J. , Moore Phillip , Javois Alexander J. , Pedra Carlos A. , Du Wei , Gruenstein Daniel H. , Wax David F. , Hill James A. , Graziano Joseph N. , Fagan Thomas E. , Alvarez Walter Mosquera , Nykanen David G. , Divekar Abhay A. 
Published: February 2014

ObjectivesWe examine normalized air Kerma area product (PKA) by body weight (PKA/BW) as a reference value of radiation dose and benchmark PKA/BW in pediatric laboratories using a multicenter registry database.BackgroundReduction of radiation dose is an important quality improvement task in pediatric cardiac catheterization laboratories. Physicians need to agree on a standard method of reporting radiation dose that would allow comparisons to be made between operators and institutions.MethodsThis was a multicenter observational study of radiation dose in pediatric laboratories. Patient demographic, procedural and radiation data including fluoroscopic time and PKA (µGy m2) were analyzed. PKA/BW was obtained by indexing PKA to body weight.ResultsA total of 8,267 pediatric catheterization procedures (age <18 years) were included from 16 institutions. The procedures consisted of diagnostic (n = 2,827), transplant right ventricular (RV) biopsy (n = 1,172), and interventional catheterizations (n = 4268). PKA correlated with body weight better than with age and best correlated with weight–fluoroscopic time product. PKA/BW showed consistent values across pediatric ages. Interventional catheterizations had the highest PKA/BW (50th, 75th, and 90th percentiles: 72, 151, and 281 μGy m2/kg), followed by diagnostic (59, 105, and 175 μGy m2/kg) and transplant RV biopsy (27, 79, and 114 μGy m2/kg).ConclusionPKA/BW appeared to be the most reliable standard to report radiation dose across all procedure types and patient age. We recommend PKA/BW to be used as the standard unit in documenting radiation usage in pediatric laboratories and can be used to evaluate strategies to lower radiation dosage in pediatric patients undergoing cardiac catheterizations. © 2014 Wiley Periodicals, Inc.
Modeling the role of the close‐range effect and environmental variables in the occurrence and spread of Phragmites australis in four sites on the Finnish coast of the Gulf of Finland and the Archipelago Sea
Authors: Altartouri Anas , Nurminen Leena , Jolma Ari 
Published: February 2014

AbstractPhragmites australis, a native helophyte in coastal areas of the Baltic Sea, has significantly spread on the Finnish coast in the last decades raising ecological questions and social interest and concern due to the important role it plays in the ecosystem dynamics of shallow coastal areas. Despite its important implications on the planning and management of the area, predictive modeling of Phragmites distribution is not well studied. We examined the prevalence and progression of Phragmites in four sites along the Southern Finnish coast in multiple time frames in relation to a number of predictors. We also analyzed patterns of neighborhood effect on the expansion and disappearance of Phragmites in a cellular data model. We developed boosted regression trees models to predict Phragmites occurrences and produce maps of habitat suitability. Various Phragmites spread figures were observed in different areas and time periods, with a minimum annual expansion rate of 1% and a maximum of 8%. The water depth, shore openness, and proximity to river mouths were found influential in Phragmites distribution. The neighborhood configuration partially explained the dynamics of Phragmites colonies. The boosted regression trees method was successfully used to interpolate and extrapolate Phragmites distributions in the study sites highlighting its potential for assessing habitat suitability for Phragmites along the Finnish coast. Our findings are useful for a number of applications. With variables easily available, delineation of areas susceptible for Phragmites colonization allows early management plans to be made. Given the influence of reed beds on the littoral species and ecosystem, these results can be useful for the ecological studies of coastal areas. We provide estimates of habitat suitability and quantification of Phragmites expansion in a form suitable for dynamic modeling, which would be useful for predicting future Phragmites distribution under different scenarios of land cover change and Phragmites spatial configuration.
Modeling of electrohydrodynamic drying process using response surface methodology
Authors: Dalvand Mohammad Jafar , Mohtasebi Seyed Saeid , Rafiee Shahin 
Published: February 2014

AbstractEnergy consumption index is one of the most important criteria for judging about new, and emerging drying technologies. One of such novel and promising alternative of drying process is called electrohydrodynamic (EHD) drying. In this work, a solar energy was used to maintain required energy of EHD drying process. Moreover, response surface methodology (RSM) was used to build a predictive model in order to investigate the combined effects of independent variables such as applied voltage, field strength, number of discharge electrode (needle), and air velocity on moisture ratio, energy efficiency, and energy consumption as responses of EHD drying process. Three‐levels and four‐factor Box–Behnken design was employed to evaluate the effects of independent variables on system responses. A stepwise approach was followed to build up a model that can map the entire response surface. The interior relationships between parameters were well defined by RSM.
Quiet T1‐weighted imaging using PETRA: Initial clinical evaluation in intracranial tumor patients
Authors: Ida Masahiro , Wakayama Toshiki , Nielsen Matthew L. , Abe Takayuki , Grodzki David M. 
Published: February 2014

PurposeTo compare the lesion contrast and signal to noise ratio (SNR) obtained with T1‐weighted pointwise encoding time reduction with radial acquisition (PETRA) to those of Magnetization‐Prepared RApid Gradient‐Echo (MPRAGE) for contrast‐enhanced imaging of primary and metastatic intracranial tumors, and to investigate whether PETRA is able to reduce acoustic noise for improved patient comfort.Materials and MethodsFifteen patients with intracranial tumors underwent 3 Tesla MRI including inversion‐prepared PETRA and MPRAGE. The two sequences had comparable scan times, spatial resolution and spatial coverage. “Tumor conspicuity” was rated qualitatively by two radiologists, while enhancing lesion‐to‐white matter contrast to noise ratio (CNR) and white‐matter SNR were analyzed quantitatively using paired t‐tests. The acoustic noise generated by each sequence was measured.ResultsQualitative rating of “tumor conspicuity” by two radiologists resulted in nearly identical average scores for the two sequences. Quantitative analyses revealed that (i) there was no significant difference between the mean CNR values of the two sequences (P = 0.57), (ii) the mean SNR of PETRA was significantly higher than that of MPRAGE (P < 0.01), and (iii) the mean sound level of PETRA was significantly lower than that of MPRAGE (P < 0.01).ConclusionInversion‐prepared PETRA was found to be viable as a quiet alternative to MPRAGE for contrast‐enhanced T1‐weighted studies of intracranial tumors. J. Magn. Reson. Imaging 2015;41:447–453.© 2013 Wiley Periodicals, Inc.
Evaluation of radiation dose to cardiac and pulmonary tissue among patients with stage IV Wilms tumor and pulmonary metastases
Authors: Farooqi Ahsan , Siddiqi Arsalan , Khan Mohammad K. , Esiashvili Natia 
Published: February 2014

BackgroundMost patients with stage IV Wilms tumor (WT) and pulmonary metastases are treated with surgery, local radiotherapy (RT), and whole‐lung irradiation (WLI). The Children's Oncology Group is studying whether WLI should only be given if metastatic lung lesions persist following induction chemotherapy. We hypothesized that radiation dose to cardiac and pulmonary organs are increased when WLI and abdominal RT fields are administered sequentially.ProcedureWe retrospectively identified 16 patients with stage IV WT and pulmonary metastases to model dosimetry plans for concurrent and sequential flank or whole abdomen and whole‐lung fields.ResultsTreatment plans were evaluated for dosimetric endpoints to the heart and the lungs.The mean dose (Gy) was significantly higher to the heart (15.8 vs. 12.1, P < 0.0001) and lungs (14.1 vs. 12.2, P < 0.0002) when patients with stage IV WT and pulmonary metastases were treated with sequential RT. The percent tissue organ volumes (V) receiving high RT doses of 15 and 20 Gy (V15 and V20) were negligible in concurrent treatment plans. Comparatively, mean V15 and V20 values for sequential treatment plans were 35% and 27%, respectively, for the heart, and 15% and 12%, for the lungs.ConclusionsThe dose to the heart and lung tissue is significantly increased when WLI and abdominal RT fields are administered sequentially. While omission of WLI may be beneficial for patients achieving good response to induction chemotherapy, the less favorable response group may be subjected to increased risk of cardiac and pulmonary toxicities from sequential WLI. Pediatr Blood Cancer 2014; 61:1394–1397. © 2014 Wiley Periodicals, Inc.
Induction of labor compared to dilation and evacuation for postmortem analysis
Authors: Lal A. K. , Kominiarek M. A. , Sprawka N. M. 
Published: February 2014

ABSTRACTObjectiveThis study aimed to evaluate the ability to obtain autopsy and cytogenetics after midtrimester termination.MethodsA retrospective cohort study of women undergoing termination, via induction or dilation and evacuation (D&E), at 16 0/7–23 6/7 weeks was performed. Exclusion criteria were elective termination, preterm labor, PPROM, and no autopsy or cytogenetic exam performed. The ability to obtain cytogenetics and autopsy as well as complications rates were compared between the two groups with Chi‐square tests.ResultsOf the 469 women who met the inclusion criteria, 158 had an induction and 312 had a D&E. The induction of labor group had higher mean gestational ages, p < 0.01. Successful autopsy was more likely in the induction group, 94.3%, versus D&E group, 34.7%, p = 0.01. There was no difference in ability to obtain cytogenetics between the two groups, 89.1% in the induction group, and 92.3% in D&E group, p = 0.4. There was a difference in the total complication rates between the groups, 9.8% (26) in the induction versus 6.4% (20) in the D&E group, p < 0.01; however, there was no difference in major complications.ConclusionsMidtrimester terminations by induction were more likely to have successful autopsies when compared with D&E. The ability to obtain cytogenetics was similar regardless of termination mode. © 2014 John Wiley & Sons, Ltd.
Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
Authors: Lv Feng-Juan , Tuan Rocky S. , Cheung Kenneth M.C. , Leung Victor Y.L. 
Published: February 2014

AbstractThe concept of mesenchymal stem cells (MSCs) is becoming increasingly obscure due to the recent findings of heterogeneous populations with different levels of stemness within MSCs isolated by traditional plastic adherence. MSCs were originally identified in bone marrow and later detected in many other tissues. Currently, no cloning based on single surface marker is capable of isolating cells that satisfy the minimal criteria of MSCs from various tissue environments. Markers that associate with the stemness of MSCs await to be elucidated. A number of candidate MSC surface markers or markers possibly related to their stemness have been brought forward so far, including Stro-1, SSEA-4, CD271, and CD146, yet there is a large difference in their expression in various sources of MSCs. The exact identity of MSCs in vivo is not yet clear, although reports have suggested they may have a fibroblastic or pericytic origin. In this review, we revisit the reported expression of surface molecules in MSCs from various sources, aiming to assess their potential as MSC markers and define the critical panel for future investigation. We also discuss the relationship of MSCs to fibroblasts and pericytes in an attempt to shed light on their identity in vivo. Stem Cells 2014;32:1408–1419
Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells
Authors: Sugrue Tara , Lowndes Noel F. , Ceredig Rhodri 
Published: February 2014

AbstractMesenchymal stromal cells (MSCs) are radioresistant bone marrow progenitors that support hematopoiesis and its reconstitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor microenvironments. The DNA damage response (DDR) represents a network of signaling pathways that enable cells to activate biological responses to DNA damaging agents. Hypoxia-mediated alterations in the DDR contribute to the increased radioresistance of hypoxic cancer cells, limiting therapeutic efficacy. The DDR is important in mediating mouse MSC radioresistance. However, the effects of hypoxia on MSC radioresistance are currently unknown. In this report, hypoxia was found to (a) increase MSC proliferation rate and colony size; (b) increase long-term survival post-irradiation (IR), and (c) improve MSC recovery from IR-induced cell cycle arrest. DNA double-strand break (DSB) repair in MSCs was upregulated in hypoxia, accelerating the resolution of highly genotoxic IR-induced DNA DSBs. In addition, HIF-1α was found to contribute to this enhanced DSB repair by regulating (a) the expression of DNA ligase IV and DNA-PKcs and (b) Rad51 foci formation in response to DNA DSBs in hypoxic MSCs. We have demonstrated, for the first time, that hypoxia enhances mouse MSC radioresistance in vitro. These findings have important implications for our understanding of MSC functions in supporting allogeneic bone marrow transplantation and in tumorigenesis. Stem Cells 2014;32:2188–2200
GCNF-Dependent Activation of Cyclin D1 Expression via Repression of Mir302a During ESC Differentiation
Authors: Wang Hongran , Wang Xiaohong , Archer Trevor K. , Zwaka Thomas P. , Cooney Austin J. 
Published: February 2014

Abstract
Cyclin D1 plays an important role in the regulation of cellular proliferation and its expression is activated during gastrulation in the mouse; however, it remains unknown how cyclin D1 expression is regulated during early embryonic development. Here, we define the role of germ cell nuclear factor (GCNF) in the activation of cyclin D1 expression during embryonic stem cell (ESC) differentiation as a model of early development. During our study of GCNF knockout (GCNF−/−) ESC, we discovered that loss of GCNF leads to the repression of cyclin D1 activation during ESC differentiation. This was determined to be an indirect effect of deregulation Mir302a, which is a cyclin D1 suppressor via binding to the 3′UTR of cyclin D1 mRNA. Moreover, we showed that Mir302 is a target gene of GCNF that inhibits Mir302 expression by binding to a DR0 element within its promoter. Inhibition of Mir302a using Mir302 inhibitor during differentiation of GCNF−/− ESCs restored cyclin D1 expression. Similarly over-expression of GCNF during differentiation of GCNF−/− ESCs rescued the inhibition of Mir302a expression and the activation of cyclin D1. These results reveal that GCNF plays a key role in regulating activation of cyclin D1 expression via inhibition of Mir302a. Stem Cells 2014;32:1527–1537