bluuebunny/crossref_metadata_2025_split huggingface dataset:
STORAGE WARS
Authors: Kersel Morag M. 
Published: March 2015

ABSTRACTWhether sponsored by academic institutions, governments, international agencies, or private landowners, the results of archaeological investigations are the same: the production of knowledge and an accumulation of things. The material manifestations (artifacts and samples) and the accompanying daily notes, digital records, maps, photographs, and plans together comprise a comprehensive record of the past. Once these items have been amassed, they are deposited in dig houses, magazines, museums, repositories, storage containers, and sometimes in personal basements and garages to be held in perpetuity. Across the globe, storage (here implying curation and permanent care) is one of the most pressing issues facing archaeology today. The following examines the curation crisis and some of the traditional and innovative solutions to the storage wars, arguing that rather than something that is viewed as a time-consuming, costly afterthought; curation should be an integral part of archaeological praxis.
A Facile Method to Establish Human Induced Pluripotent Stem Cells From Adult Blood Cells Under Feeder-Free and Xeno-Free Culture Conditions: A Clinically Compliant Approach
Authors: Chou Bin-Kuan , Gu Haihui , Gao Yongxing , Dowey Sarah N. , Wang Ying , Shi Jun , Li Yanxin , Ye Zhaohui , Cheng Tao , Cheng Linzhao 
Published: March 2015

Abstract
Reprogramming human adult blood mononuclear cells (MNCs) cells by transient plasmid expression is becoming increasingly popular as an attractive method for generating induced pluripotent stem (iPS) cells without the genomic alteration caused by genome-inserting vectors. However, its efficiency is relatively low with adult MNCs compared with cord blood MNCs and other fetal cells and is highly variable among different adult individuals. We report highly efficient iPS cell derivation under clinically compliant conditions via three major improvements. First, we revised a combination of three EBNA1/OriP episomal vectors expressing five transgenes, which increased reprogramming efficiency by ≥10–50-fold from our previous vectors. Second, human recombinant vitronectin proteins were used as cell culture substrates, alleviating the need for feeder cells or animal-sourced proteins. Finally, we eliminated the previously critical step of manually picking individual iPS cell clones by pooling newly emerged iPS cell colonies. Pooled cultures were then purified based on the presence of the TRA-1-60 pluripotency surface antigen, resulting in the ability to rapidly expand iPS cells for subsequent applications. These new improvements permit a consistent and reliable method to generate human iPS cells with minimal clonal variations from blood MNCs, including previously difficult samples such as those from patients with paroxysmal nocturnal hemoglobinuria. In addition, this method of efficiently generating iPS cells under feeder-free and xeno-free conditions allows for the establishment of clinically compliant iPS cell lines for future therapeutic applications.
Redonner la parole au sujet. Une proposition de travail à court terme, dans un contexte institutionnel
Authors: Riaño Patricia 
Published: March 2015

L’analyste travaillant en institution peut s’inspirer du travail réalisé pendant les « entretiens préliminaires à l’analyse » pour redonner la parole au sujet en dispositifs à court terme, tout en respectant les conditions de la position de l’analyste établies par Freud et Lacan. Cette proposition a été mise en place par l’auteure notamment dans un projet au sein d’un CSSS.
Entre dinosaures et Don Quichotte : « rouler avec la résistance »… de l’institution. Une utopie ?
Authors: Levert Carole 
Published: March 2015

À partir des enjeux auxquels font face les psychanalystes inscrits dans le travail institutionnel et des formations obligatoires auxquelles on les soumet, nommément l’approche motivationnelle et l’approche du rétablissement en santé mentale, deux positions de l’auteure s’affrontent. Dans le respect à la fois de son éthique et de son autonomie professionnelles, quelle place le psychanalyste peut-il trouver pour lui-même et pour l’Autre qu’il écoute ? Confronté à des paradigmes qui ne sont pas les siens, où le sujet se voit réduit aux considérations marchandes des données probantes, il est appelé à tenter quelques petites subversions pour sortir de l’écheveau normatif et quantifiable, un brin de création et d’inattendu. Il est néanmoins violemment exposé aux discours vides, aux mots-clés, écartant l’essentiel de la souffrance humaine : son sens. Tout en brossant un tableau de l’état des lieux, l’auteure questionne et critique l’insensé contenu dans ces « bonnes pratiques » avec, en fil d’Ariane, les questions « qu’est la psychanalyse devenue ? » mais aussi que deviendra-t-elle ?
Aerosol‐cloud interactions in ship tracks using Terra MODIS/MISR
Authors: Chen Yi‐Chun , Christensen Matthew W. , Diner David J. , Garay Michael J. 
Published: March 2015

AbstractSimultaneous ship track observations from Terra Moderate Resolution Imaging Spectroradiometer (MODIS) and Multiangle Imaging Spectroradiometer (MISR) have been compiled to investigate how ship‐injected aerosols affect marine warm boundary layer clouds for different cloud types and environmental conditions. By taking advantage of the high spatial resolution multiangle observations available from MISR, we utilized the retrieved cloud albedo, cloud top height, and cloud motion vectors to examine cloud property responses in ship‐polluted and nearby unpolluted clouds. The strength of the cloud albedo response to increased aerosol level is primarily dependent on cloud cell structure, dryness of the free troposphere, and boundary layer depth, corroborating a previous study by Chen et al. (2012) where A‐Train satellite data were utilized. Under open cell cloud structure the cloud properties are more susceptible to aerosol perturbations as compared to closed cells. Aerosol plumes caused an increase in liquid water amount (+38%), cloud top height (+13%), and cloud albedo (+49%) for open cell clouds, whereas for closed cell clouds, little change in cloud properties was observed. Further capitalizing on MISR's unique capabilities, the MISR cross‐track cloud speed was used to derive cloud top divergence. Statistically averaging the results from the identified plume segments to reduce random noise, we found evidence of cloud top divergence in the ship‐polluted clouds, whereas the nearby unpolluted clouds showed cloud top convergence, providing observational evidence of a change in local mesoscale circulation associated with enhanced aerosols. Furthermore, open cell polluted clouds revealed stronger cloud top divergence as compared to closed cell clouds, consistent with different dynamical mechanisms driving their responses. These results suggest that detailed cloud responses, classified by cloud type and environmental conditions, must be accounted for in global climate modeling studies to reduce uncertainties in calculations of aerosol indirect forcing.
Parametric sensitivity analysis of precipitation at global and local scales in the Community Atmosphere Model CAM5
Authors: Qian Yun , Yan Huiping , Hou Zhangshuan , Johannesson Gardar , Klein Stephen , Lucas Donald , Neale Richard , Rasch Philip , Swiler Laura , Tannahill John , Wang Hailong , Wang Minghuai , Zhao Chun 
Published: March 2015

AbstractWe investigate the sensitivity of precipitation characteristics (mean, extreme, and diurnal cycle) to a set of uncertain parameters that influence the qualitative and quantitative behavior of cloud and aerosol processes in the Community Atmosphere Model (CAM5). We adopt both the Latin hypercube and Quasi‐Monte Carlo sampling approaches to effectively explore the high‐dimensional parameter space and then conduct two large sets of simulations. One set consists of 1100 simulations (cloud ensemble) perturbing 22 parameters related to cloud physics and convection, and the other set consists of 256 simulations (aerosol ensemble) focusing on 16 parameters related to aerosols and cloud microphysics. In the cloud ensemble, six parameters having the greatest influences on the global mean precipitation are identified, three of which (related to the deep convection scheme) are the primary contributors to the total variance of the phase and amplitude of the precipitation diurnal cycle over land. The extreme precipitation characteristics are sensitive to a fewer number of parameters. Precipitation does not always respond monotonically to parameter change. The influence of individual parameters does not depend on the sampling approaches or concomitant parameters selected. Generally, the Generalized Linear Model is able to explain more of the parametric sensitivity of global precipitation than local or regional features. The total explained variance for precipitation is primarily due to contributions from the individual parameters (75–90% in total). The total variance shows a significant seasonal variability in midlatitude continental regions, but very small in tropical continental regions.
Rupture termination at restraining bends: The last great earthquake on the Altyn Tagh Fault
Authors: Elliott Austin J. , Oskin Michael E. , Liu‐Zeng Jing , Shao Yanxiu 
Published: March 2015

AbstractStrike‐slip rupture propagation falters where changes in fault strike increase Coulomb failure stress. Numerical models of this phenomenon offer predictions of rupture extent based on bend geometry, but have not been verified with field data. To test model predictions of rupture barriers, we examine rupture extent along a section of the sinistral Altyn Tagh Fault punctuated by three major double bends. We measure 3–8 m offsets and map >95 km of continuous scarps that define the most recent surface rupture. We document the eastern terminus of this rupture within the Aksay bend, where an undeformed Pleistocene alluvial fan we mapped and dated overlaps the fault. We conclude, based on this geomorphologic evidence, that multiple Holocene ruptures have stopped in the Aksay bend. Our field data validate model predictions of rupture termination at a >18° restraining bend and support use of geometric parameters to define expected earthquake sizes in seismic hazard models.
Addition‐Elimination of Aryldimethylaluminum Reagents to Vinylarenes Promoted by the Addition of a Ketone
Authors: Itami Kazuki , Tanaka Shota , Sunahara Kazuhiro , Tatsuta Go , Mori Atsunori 
Published: March 2015

AbstractAddition‐elimination reactions of an arylaluminum reagent with vinylarenes is achieved mediated by a rhodium catalyst. The reaction of dimethyl(phenyl)aluminum with a rhodium(I) catalyst takes place to afford (E)‐stilbene. The reaction is promoted by the addition of ketone as an additive to give (E)‐stilbene in a quantitative yield. A nickel complex bearing cyclopentadienyl (Cp) and N‐heterocyclic carbene (NHC) ligands also catalyzes the reaction to afford 1,2‐diarylethenes accompanied by a small amount of the saturated byproduct, 1,2‐diarylethanes.
Real‐Time Monitoring of Cancer Cell Metabolism and Effects of an Anticancer Agent using 2D In‐Cell NMR Spectroscopy
Authors: Wen He , An Yong Jin , Xu Wen Jun , Kang Keon Wook , Park Sunghyouk 
Published: March 2015

AbstractAltered metabolism is a critical part of cancer cell properties, but real‐time monitoring of metabolomic profiles has been hampered by the lack of a facile method. Here, we propose real‐time metabolomic monitoring of live cancer cells using 13C6‐glucose and heteronuclear two‐dimensional (2D) NMR. The method allowed for metabolomic differentiation between cancer and normal cells on the basis of time‐dependent changes in metabolite concentrations. Cancer cells were found to have large in‐ and out‐flux of pyruvate as well as increased net production of alanine and acetate. The method also enabled evaluation of the metabolic effects of galloflavin whose anticancer effects have been attributed to its specific inhibition of lactate dehydrogenase. Our approach revealed previously unknown functional targets of galloflavin, which were further confirmed at the protein levels. Our method is readily applicable to the study of metabolic alterations in other cellular disease model systems.
Unexpected Chemistry from the Reaction of Naphthyl and Acetylene at Combustion‐Like Temperatures
Authors: Parker Dorian S. N. , Kaiser Ralf. I. , Bandyopadhyay Biswajit , Kostko Oleg , Troy Tyler P. , Ahmed Musahid 
Published: March 2015

AbstractThe hydrogen abstraction/acetylene addition (HACA) mechanism has long been viewed as a key route to aromatic ring growth of polycyclic aromatic hydrocarbons (PAHs) in combustion systems. However, doubt has been drawn on the ubiquity of the mechanism by recent electronic structure calculations which predict that the HACA mechanism starting from the naphthyl radical preferentially forms acenaphthylene, thereby blocking cyclization to a third six‐membered ring. Here, by probing the products formed in the reaction of 1‐ and 2‐naphthyl radicals in excess acetylene under combustion‐like conditions with the help of photoionization mass spectrometry, we provide experimental evidence that this reaction produces 1‐ and 2‐ethynylnaphthalenes (C12H8), acenaphthylene (C12H8) and diethynylnaphthalenes (C14H8). Importantly, neither phenanthrene nor anthracene (C14H10) was found, which indicates that the HACA mechanism does not lead to cyclization of the third aromatic ring as expected but rather undergoes ethynyl substitution reactions instead.
Direct Observation of Ca2+‐Induced Calmodulin Conformational Transitions in Intact Xenopus laevis Oocytes by 19F NMR Spectroscopy
Authors: Ye Yansheng , Liu Xiaoli , Xu Guohua , Liu Maili , Li Conggang 
Published: March 2015

AbstractThe Ca2+‐mediated conformational transition of the protein calmodulin (CaM) is essential to a variety of signal transduction pathways. Whether the transition in living cells is similar to that observed in buffer is not known. Here, we report the direct observation by 19F NMR spectroscopy of the transition of the Ca2+‐free and ‐bound forms in Xenopus laevis oocytes at different Ca2+ levels. We find that the Ca2+‐bound CaM population increased greatly upon binding the target protein myosin light‐chain kinase (MLCK) at the same Ca2+ level. Paramagnetic NMR spectroscopy was also exploited for the first time to obtain long‐range structural constraints in cells. Our study shows that 19F NMR spectroscopy can be used to obtain long‐range structural constraints in living eukaryotic cells and paves the way for quantification of protein binding constants.
Synthesis and Characterization of Tricarbastannatranes and Their Reactivity in B(C6F5)3‐Promoted Conjugate Additions
Authors: Kavoosi Azadeh , Fillion Eric 
Published: March 2015

AbstractThe synthesis and characterization of a series of tricarbastannatranes, in the solid state and in solution, are described. The structures of the complexes [N(CH2CH2CH2)3Sn](BF4), [N(CH2CH2CH2)3Sn](SbF6), [N(CH2CH2CH2)3Sn]4[(SbF6)3Cl], and [(N(CH2CH2CH2)3Sn)2OH][MeB(C6F5)3] were determined by X‐ray crystallography. Furthermore, the B(C6F5)3‐promoted conjugate addition of alkyl‐tricarbastannatranes to benzylidene derivatives of Meldrum’s acid was investigated, and detailed mechanistic studies are presented.
Zero‐order release three‐layered tablet with an acemetacin solid dispersion core and a hydroxypropyl methylcellulose capped matrix
Authors: Qi Xiaole , Jiang Yujie , Li Xiangbo , Zhang Ziwei , Wu Zhenghong 
Published: March 2015

ABSTRACTThe purpose of this study was to prepare a three‐layered tablet with hydroxypropyl methylcellulose (HPMC) polymers as a capped matrix to achieve a zero‐order release for acemetacin. As the middle active core, a solid dispersion in poly(vinyl pyrrolidone)–K30 polymers was manufactured via a solvent method to improve the solubility of acemetacin. A Box–Behnken design was used to optimize the formula, when the amounts of HPMC in the middle layer, HPMC in the external layer, and mannitol in the middle layer were chosen as the influencing factors. The dissolution profiles of the optimized formula exhibited superior fitting to the zero‐order release in 24 h. A bioavailability experiment was carried out by the administration of those three‐layered tablets to rabbits and their comparison with market Gaoshunsong controlled release capsules. The delayed time to reach the maximum plasma concentration, decreased the maximum plasma concentration, area under the plasma concentration‐time curve (0–48 h) AUC0–48, and area under the plasma concentration‐time curve (0–∞) AUC0–∞ were 9.33 ± 2.51 h, 8.59 ± 0.94 µg/mL, 200.81 ± 11.36 µg h/mL, and 212.902 ± 31.66 µg h/mL, respectively. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42059.
Composite chitosan/poly(ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs
Authors: Cheng Feng , Gao Jing , Wang Lu , Hu Xingyou 
Published: March 2015

ABSTRACTThe aim of this study was to develop novel biomedical electrospun nanofiber mats for controlled drug release, in particular to release a drug directly to an injury site to accelerate wound healing. Here, nanofibers of chitosan (CS), poly(ethylene oxide) (PEO), and a 90 : 10 composite blend, loaded with a fluoroquinolone antibiotic, such as ciprofloxacin hydrochloride (CipHCl) or moxifloxacin hydrochloride (Moxi), were successfully prepared by an electrospinning technique. The morphology of the electrospun nanofibers was investigated by scanning electron microscopy. The functional groups of the electrospun nanofibers before and after crosslinking were characterized by Fourier transform infrared spectroscopy. X‐ray diffraction results indicated an amorphous distribution of the drug inside the nanofiber blend.In vitrodrug‐release evaluations showed that the crosslinking could control the rate and period of drug release in wound‐healing applications. The inhibition of bacterial growth for bothEscherichia coliandStaphylococcus aureuswere achieved on the CipHCl‐ and Moxi‐loaded nanofibers. In addition, both types of CS/PEO and drug‐containing CS/PEO nanofibers showed excellent cytocompatibility in the cytotoxicity assays. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42060.
Thermal aging and accelerated weathering of PVC/MMT nanocomposites: Structural and morphological studies
Authors: Pagacz Joanna , Chrzanowski Michał , Krucińska Izabella , Pielichowski Krzysztof 
Published: March 2015

ABSTRACTThis work focuses on the influence of weathering factors—UV radiation, humidity, and temperature on the structure and morphology of poly(vinyl chloride)/montmorillonite (PVC/MMT) nanocomposites obtained by melt blending. It has been observed that organically modified MMT (OMMT) deteriorates the weathering resistance, the thermal behavior, as well as the long‐term stability of PVC. Decomposition of the organic modifier of MMT causes substantial color changes in the PVC nanocomposites as it facilitates the dehydrochlorination process of the polymer. However, the nonmodified MMT provides some stabilization during PVC weathering. The nanocomposites after annealing are characterized by higher glass transition temperature. The increase in heat capacity step (Δcp) during glass transition suggests that in the PVC composites with nonmodified MMT stronger molecular interactions between the polymer and clay platelets occur than in PVC/OMMT nanocomposites. The scanning electron microscopy images on the surface and the cross section show that thermal aging and weathering proceed by different mechanisms. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42090.
Allais from Experience: Choice Consistency, Rare Events, and Common Consequences in Repeated Decisions
Authors: Harman Jason L. , Gonzalez Cleotilde 
Published: March 2015

AbstractThe Allais Paradox is a well‐known bias in which people's preferences result in contradictory choices between two normatively identical gamble pairs. Studies have shown that these preference reversals depend on how information is described and presented. In an experiment, we investigate the Allais gambles in several formats including an experiential paradigm, where participants make selections from two blank buttons and get an outcome as a result of a draw from distributions of outcomes in the selected gamble. Results indicate that a large proportion of Allais reversals are found in the traditional descriptive format, they are reduced when gambles are presented in a descriptive table format, and they disappear when choices are made from experience. Although a majority of participants made consistent choices from experience, the proportion of individual reversals is similar to that of descriptive choices. Detailed analyses of experiential choice suggest interesting behavioral differences between participants classified as consistent and those classified as reversals: consistent participants explore and maximize more than reversal participants. Furthermore, consistent participants demonstrate a different switching behavior after experiencing a rare outcome than do reversal participants. We find that, both, overweighting or underweighting of rare outcomes may occur within the course of an individual's experience; depending on the timing of those experiences, the magnitude of the outcomes observed, and the general accumulated value of the gambles. Copyright © 2015 John Wiley & Sons, Ltd.
Integrating bio‐inorganic and analytical chemistry into an undergraduate biochemistry laboratory
Authors: Erasmus Daniel J. , Brewer Sharon E. , Cinel Bruno 
Published: March 2015

AbstractUndergraduate laboratories expose students to a wide variety of topics and techniques in a limited amount of time. This can be a challenge and lead to less exposure to concepts and activities in bio‐inorganic chemistry and analytical chemistry that are closely‐related to biochemistry. To address this, we incorporated a new iron determination by atomic absorption spectroscopy exercise as part of a five‐week long laboratory‐based project on the purification of myoglobin from beef. Students were required to prepare samples for chemical analysis, operate an atomic absorption spectrophotometer, critically evaluate their iron data, and integrate these data into a study of myoglobin. © 2015 by The International Union of Biochemistry and Molecular Biology, 43(2):121–125, 2015.
Fast prototyping of image processing application on android platform focused on PDF417 decoder
Authors: Ahmad Maqsood , Bajwa Khalid Bashir , Saleem Rashid , Umer F. 
Published: March 2015

ABSTRACTDedicated Hardware for two dimensional (2D) barcodes is used in numerous applications depending on the levels of preserving data in complex format. These modules are complex in their design and also take considerable amount of time for their development, testing and verification both at software and hardware levels. On the other hand, modern android mobile/tablets are ready to use hardware platform that fulfills all the essential hardware requirements to implement the extraction of barcodes. Additionally, they got the capability to run the complex image processing algorithms on application level, which increases the prototyping speed considerably for 2D barcode implementation. In order to reduce the algorithm complexity further, different techniques have been devised on hardware level such as light conditioning and orientation, placement of barcode and distance from the camera. The system has been effectively deployed for the decoding of PDF 417 codes on student university cards at the university. © 2015 Wiley Periodicals, Inc. Comput Appl Eng Educ 23:596–602, 2015; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21630