bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Endoscopic Treatment for Greater Trochanteric Pain Syndrome: Minimum of Two-Year Follow-Up
Authors: Domb Benjamin G. , Lindner Dror , Schwindel Leslie , Stake Christine E. , El Bitar Youssef 
Published: April 2014

Objectives: Greater trochanteric pain syndrome (GTPS) is a common complaint with an estimated incidence of 1.8/1,000 persons. GTPS usually responds well to conservative treatment. In refractory cases, endoscopy offers a less invasive approach than open surgery, and offers the advantage of evaluating and treating coexistent intraarticular disorders. The purpose of this study is to report the clinical outcomes of endoscopic treatment for GTPS at a minimum of two years follow-up and to report the incidence and outcomes of hip abductor tears. Methods: During the study period, patients who presented with lateral hip pain, pain on palpation over the greater trochanter or hip abductor weakness and were treated with an endoscopic trochanteric bursectomy were included. Exclusion criteria were previous hip conditions and Tonnis grade ≥ 2. Patient reported outcome (PRO) scores used include the modified Harris Hip Score (mHHS), the Non-Arthritic Hip Score (NAHS), the Hip Outcome Score-Activities of Daily Living (HOS-ADL), and the Hip Outcome Score-Sport Specific Subscale (HOS-SSS). PRO scores were collected pre-operatively and two-years postoperatively. Visual analog scale (VAS) scores and patient satisfaction ratings were also collected. Any revision surgeries, complications, or conversions to total hip arthroplasty (THA) were noted. Results: A total of 59 cases met the inclusion/exclusion criteria, of which 50 patients (85%) were available for follow-up at minimum two years. Forty-six patients reported two-year follow up PRO scores and four patients needed total hip replacement surgery. All patients had endoscopic trochanteric bursectomy. Thirteen patients (26%) had a gluteus medius tear treated during surgery. Average follow up was 31 months (range 24-50). Average age was 50 years (range 23-75). Patients demonstrated significant improvement (p<0.01) from pre-operative to last follow-up in all PROs. Patients who underwent gluteus medius (GM) repair demonstrated higher improvement in all PROs compared to patients without GM pathology (Table 1). Four patients (8%) went on to have THA, three patients (6%) required revision arthroscopy. Nine patients (18%) had a complication; however, all were transient and none required further surgical intervention. Conclusion: Patients experienced a statistically significant clinical improvement in PROs, and pain scores, and reported high satisfaction after endoscopic trochanteric bursectomy with or without gluteus medius repair. We conclude that peritrochanteric endoscopy is a safe and efficient treatment option for recalcitrant GTPS.
Performance and Return-to-Sport after Tommy John Surgery in Major League Baseball Pitchers
Authors: Gupta Anil Kumar , Erickson Brandon J. , Harris Joshua David , Bach Bernard R. , Abrams Geoffrey D. , Juan Angielyn San , Cole Brian J. , Bush-Joseph Charles A. , Romeo Anthony A. 
Published: April 2014

Objectives: Ulnar collateral ligament reconstruction (UCLR) is a common procedure performed in Major League Baseball (MLB) pitchers with symptomatic UCL deficiencies. The purpose of this study was to determine: 1) the rate of return to pitching in the MLB following UCLR, 2) performance after return to pitching, and 3) the difference in return to pitching and performance between pitchers who underwent UCLR and matched controls who did not. Methods: MLB pitchers with symptomatic UCL deficiency that underwent UCLR between 1986 and 2012 were evaluated. Players' data was extracted from MLB team websites, injury reports, player profiles/biographies, press releases and cross-referenced with the MLB injury database (MLB411). All player, elbow, and surgical demographic data were analyzed. Age, body mass index (BMI), position, handedness, and MLB experience-matched controls were selected from the MLB during the same years as those undergoing UCLR. An "index year" was designated for controls, analogous to UCLR year in cases. Return to pitching and performance measures in MLB was compared between cases and controls. Student's t-tests were performed for analysis of within-group and between-group variables, respectively. Results: One hundred forty-eight pitchers (83%) were able to return to pitching in MLB. Length of career in MLB following UCLR was 3.9 +/- 2.84 years. Revision rate was 3.9%. In the year prior to UCLR (or index year in controls), cases were significantly (p<0.05) worse than controls with regard to number of innings pitched, games played, wins, and winning percentage and were not significantly different than controls in all remaining parameters. Pitchers undergoing UCLR had significantly (p<0.05) fewer losses, a lower losing percentage, and lower earned run average (ERA) following surgery (versus pre-surgery). In addition, cases threw significantly (p<0.05) fewer walks and allowed fewer hits, runs, and home runs following surgery. Comparisons between cases and controls for the timeframe following UCLR (cases) or index year (controls) demonstrated that cases had significantly (p<0.05) fewer losses per season and a lower losing percentage. In addition, cases had a significantly lower ERA and fewer walks and hits allowed per inning pitched (WHIP) (Table 1). Conclusion: There is a high rate of return to pitching in the MLB following UCLR. Performance declined prior to surgery and improved following surgery. When comparing to demographic-matched controls, UCLR had better results in multiple performance measures. Ulnar collateral ligament reconstruction allows for a predictable and successful return to professional-level baseball.
Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis
Authors: Denkinger Claudia M. , Schumacher Samuel G. , Boehme Catharina C. , Dendukuri Nandini , Pai Madhukar , Steingart Karen R. 
Published: April 2014

Xpert MTB/RIF (Cepheid, Sunnyvale, CA, USA) is endorsed for the detection of pulmonary tuberculosis (TB). We performed a systematic review and meta-analysis to assess the accuracy of Xpert for the detection of extrapulmonary TB.We searched multiple databases to October 15, 2013. We determined the accuracy of Xpert compared with culture and a composite reference standard (CRS). We grouped data by sample type and performed meta-analyses using a bivariate random-effects model. We assessed sources of heterogeneity using meta-regression for predefined covariates.We identified 18 studies involving 4461 samples. Sample processing varied greatly among the studies. Xpert sensitivity differed substantially between sample types. In lymph node tissues or aspirates, Xpert pooled sensitivity was 83.1% (95% CI 71.4–90.7%)versusculture and 81.2% (95% CI 72.4–87.7%)versusCRS. In cerebrospinal fluid, Xpert pooled sensitivity was 80.5% (95% CI 59.0–92.2%) against culture and 62.8% (95% CI 47.7–75.8%) against CRS. In pleural fluid, pooled sensitivity was 46.4% (95% CI 26.3–67.8%) against culture and 21.4% (95% CI 8.8–33.9%) against CRS. Xpert pooled specificity was consistently >98.7% against CRS across different sample types.Based on this systematic review, the World Health Organization now recommends Xpert over conventional tests for diagnosis of TB in lymph nodes and other tissues, and as the preferred initial test for diagnosis of TB meningitis.
Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4ratio in children with cystic fibrosis
Authors: Ringholz Fiona C. , Buchanan Paul J. , Clarke Donna T. , Millar Roisin G. , McDermott Michael , Linnane Barry , Harvey Brian J. , McNally Paul , Urbach Valerie 
Published: April 2014

Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance, persistent bacterial infection and neutrophilic inflammation. Lipoxin A4(LXA4) initiates the active resolution of inflammation and promotes airway surface hydration in CF models. 15-Lipoxygenase (LO) plays a central role in the “class switch” of eicosanoid mediator biosynthesis from leukotrienes to lipoxins, initiating the active resolution of inflammation. We hypothesised that defective eicosanoid mediator class switching contributes to the failure to resolve inflammation in CF lung disease.Using bronchoalveolar lavage (BAL) samples from 46 children with CF and 19 paediatric controls we demonstrate that the ratio of LXA4to leukotriene B4(LTB4) is depressed in CF BAL (p<0.01), even in the absence of infection (p<0.001).Furthermore, 15-LO2 transcripts were significantly less abundant in CF BAL samples (p<0.05). In control BAL, there were positive relationships between 15-LO2 transcript abundance and LXA4/LTB4ratio (p=0.01, r=0.66) and with percentage macrophage composition of the BAL fluid (p<0.001, r=0.82), which were absent in CF.Impoverished 15-LO2 expression and depression of the LXA4/LTB4ratio are observed in paediatric CF BAL. These observations provide mechanistic insights into the failure to resolve inflammation in the CF lung.
Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study
Authors: Kent Brian D. , Grote Ludger , Bonsignore Maria R. , Saaresranta Tarja , Verbraecken Johan , Lévy Patrick , Sliwinski Pawel , Tkacova Ruzena , Kvamme John-Arthur , Fietze Ingo , Hedner Jan , McNicholas Walter T. 
Published: April 2014

Obstructive sleep apnoea (OSA) is associated with increased risk of dysglycaemia but the intimate link of these conditions with obesity makes discerning an independent relationship between them challenging. Glycosylated haemoglobin (HbA1c) levels predict adverse cardiovascular outcomes in nondiabetics but there is a lack of population-level data exploring the relationship of HbA1c with OSA.A cross-sectional analysis of 5294 participants in the multinational European Sleep Apnoea Cohort (European Sleep Apnoea Database) study was performed, assessing the relationship of OSA severity with HbA1c levels in nondiabetic subjects, with adjustment for confounding factors.HbA1c levels correlated significantly with OSA severity in univariate analysis. Following adjustment for confounding factors, apnoea–hypopnoea index (AHI) (standardised β 0.158; p<0.001), along with nocturnal hypoxaemia, predicted HbA1c. Adjusted mean HbA1c levels were lower in the lowest AHI quartile (5.24%, 95% CI 5.21–5.27%) than in the second (5.37%, 95% CI 5.34–5.40%), third (5.44%, 95% CI 5.41–5.47%) or highest (5.50%, 95% CI 5.46–5.53%) quartiles. Subjects in the higher quartiles had significantly greater adjusted odds ratios of HbA1c level ≥6.0% than those in the first quartile. In stratified analyses, OSA severity predicted glycaemic health irrespective of sleep study modality, sex, obesity or daytime sleepiness.OSA severity independently predicts glycaemic health in nondiabetic subjects. Further studies should assess the impact of OSA treatment on glycaemic health and elucidate underlying mechanisms.
Galectin-1 and Galectin-3 mRNA expression in renal cell carcinoma
Authors: von Klot Christoph-A , Kramer Mario W , Peters Inga , Hennenlotter Joerg , Abbas Mahmoud , Scherer Ralph , Herrmann Thomas RW , Stenzl Arnulf , Kuczyk Markus A , Serth Juergen , Merseburger Axel S 
Published: April 2014

AbstractBackgroundGalectins are known to regulate cell differentiation and growth as well as cell adhesion and apoptosis. Galectins have been discussed as possible prognosticators for survival in renal cell cancer (RCC) and other urological tumors. They might also play an emerging role as possible new marker-proteins for RCC. In this study, we analyzed the expression of galectin-1 and galectin-3 mRNA in order to further investigate their clinical significance in RCC.MethodsTissue samples were obtained from 106 patients undergoing surgery for RCC. The expression of galectin-1 and galectin-3 mRNA in normal kidney and corresponding cancer tissue was analyzed using quantitative real time PCR. Differences in expression levels of paired tissue samples were assessed using paired two-sample tests. Associations of relative mRNA expression levels in tumor tissues with clinical findings were analyzed using univariate logistic regression.ResultsThe expression of galectin-1 (p < 0.001) and -3 (p < 0.001) mRNA were significantly higher in RCC when compared to the adjacent normal kidney tissue. For clear cell RCC, an association of male gender with higher galectin-1 and galectin-3 mRNA expression (p = 0.054, p = 0.034) was detected. For all RCCs, galectin-1 mRNA expression failed to show a significant association with advanced disease as well as a higher rate of lymph node metastases (p = 0.058, p = 0.059).ConclusionThe mRNA expression of galectin-1 and galectin-3 is significantly increased in RCC cancer tissue. The higher mRNA expression in tumor tissue of male patients raises the question of a functional connection between galectins and the higher prevalence of RCC in men. Associations with advanced disease might lead to new ways of identifying patients at higher risk of recurrent disease and might even facilitate early metastasectomy with curative intent.
Association of adiponectin with hepatic steatosis: a study of 1,349 subjects in a random population sample
Authors: Flechtner-Mors Marion , George Samuel N , Oeztuerk Suemeyra , Haenle Mark M , Koenig Wolfgang , Imhof Armin , Boehm Bernhard O , Graeter Tilmann , Mason Richard A , Kratzer Wolfgang , Akinli Atilla S ,   the EMIL-Study group
Published: April 2014

Abstract

Background
Objective of the present study was to examine the association between adiponectin and hepatic steatosis, and other biochemical and anthropometric parameters in healthy subjects.

Results
A total of 1349 subjects (age 18–65 years) underwent ultrasound examination of the liver. Mean adiponectin concentration for the study collective was 11.35 ± 6.28 μg/mL. The following parameters were assessed for their association with adiponectin: body-mass index (BMI); age; sex; arterial blood pressure; nicotine use; alcohol consumption; physical activity; metabolic syndrome; total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol; triglycerides; aspartate aminotransferase (AST); alanine aminotransferase (ALT); γ-glutamyltransferase (GGT); alkaline phosphatase (AP); C-reactive protein (CRP); insulin sensitivity according to the Homeostasis Model Assessment (HOMA); random blood glucose; and the degree of steatosis of the liver. The numerical differences in the variables influencing adiponectin returned in the descriptive analysis were confirmed at bivariate analysis for BMI, ALT, AST, GGT, AP, total and HDL cholesterol, triglycerides, CRP, arterial blood pressure, metabolic syndrome, nicotine use and alcohol consumption. The logistic regression of the multivariate analysis showed that male sex, hepatic steatosis, BMI, metabolic syndrome, tobacco smoking and CRP correlate negatively with adiponectin, while age, moderate alcohol consumption and HDL cholesterol exhibit a positive association.

Conclusions
The results of the present study confirm the findings of previous research. Adiponectin correlates negatively with cardiometabolic risk factors and is an independent indicator for non-alcoholic fatty liver disease (NAFLD).
Low-Temperature Synthesis of Perovskite-Type (Na,K)NbO3 through Nb6O198− Clusters by Dissolution–Precipitation Method
Authors: Shibata Kengo , Yamazoe Seiji , Wada Takahiro 
Published: April 2014

Abstract
We successfully synthesized perovskite-type (Na1−xKx)NbO3 materials from a Na3NbO4 precursor at low temperature by dissolution–precipitation method. The Nb6O198− cluster was formed as an intermediate by the dissolution of Na3NbO4 into a buffer solution (pH 7). White powders were precipitated by the addition of 1 M NaOH/KOH mixed aqueous solution. We found that the morphology and crystal structure depended on the NaOH/KOH ratio. When the concentration of KOH [CKOH = KOH/(NaOH + KOH)] was low (0 ≤ CKOH ≤ 0.3), rod-like (Na,K,H3O)8Nb6O19·14H2O was precipitated. In the case of high CKOH (0.5 ≤ CKOH ≤ 0.9), (Na0.5K0.5)8Nb6O19·9H2O, whose morphologies changed from hexagonal plate-like to truncated hexagonal bipyramidal structures with the increase in the CKOH, was formed. The (Na,K,H3O)8Nb6O19·14H2O and (Na0.5K0.5)8Nb6O19·9H2O mixture was precipitated using a NaOH/KOH solution with CKOH = 0.4. No precipitation was obtained by the addition of the KOH solution. These precipitations transformed into perovskite-type (Na,K)NbO3 while maintaining their morphology by calcination at 500 °C. The excess Na and/or K were washed out with water. From the lattice constants, the rod-like (Na1−xKx)NbO3 with 0 ≤ x ≤ 0.2 and the hexagonal plate-like or the truncated hexagonal bipyramidal (Na0.5K0.5)NbO3 were synthesized from the rod-like (Na,K,H3O)8Nb6O19·14H2O (0 ≤ CKOH ≤ 0.3) and the hexagonal plate-like or the truncated hexagonal bipyramidal (Na0.5K0.5)8Nb6O19·9H2O (0.5 ≤ CKOH ≤ 0.9), respectively.
First-principle Calculation Evaluations for MTW-type Zeolite Synthesis Prescriptions
Authors: Feng Gang , Lu Zhang-Hui , Kong Dejin , Yang Deqin , Guo Hongli , Liu Jianwen 
Published: April 2014

Abstract
We present a thermodynamics model to evaluate zeolite synthesis prescriptions with first-principle calculations, which provide quick ways for prescription optimization. Taking MTW-type zeolites as an example, our results indicate that the framework and alkali ions selection follow the order: Al &gt; Fe ≈ Ga &gt; B, Li &gt; Na ≈ K &gt; NH4 &gt; H. These results agree well with the reported experiments.
Efficient Synthetic Photocyclization for Phenacenes Using a Continuous Flow Reactor
Authors: Okamoto Hideki , Takane Takamitsu , Gohda Shin , Kubozono Yoshihiro , Sato Kaori , Yamaji Minoru , Satake Kyosuke 
Published: April 2014

Abstract
The continuous flow reaction technique has been applied to the photocyclization of 1,2-diarylethenes, the so-called Mallory reaction, to afford phenacenes in high chemical yields and efficiencies (114–288 mg h−1). The present technique will allow us to produce several grams of phenacenes at a time.
Abrupt Phase Transition Based on Electron-transfer-coupled Spin Transition in a Cyanide-bridged [Co2Fe2] Tetranuclear Complex
Authors: Sekine Yoshihiro , Nihei Masayuki , Oshio Hiroki 
Published: April 2014

Abstract
A cyanide-bridged tetranuclear complex, [Co2Fe2(CN)6(tp*)2(dmbpy)4](PF6)2·4CH3CN (1·4CH3CN) (tp*: hydrotris(3,5-dimethylpyrazol-1-yl)borate and dmbpy: 5,5′-dimethyl-2,2′-bipyridine), was synthesized and its magnetic properties were investigated. Magnetic susceptibility measurements revealed that 1 exhibited an abrupt one-step thermal phase transition based on electron-transfer-coupled spin transition (ETCST) and light-induced ETCST at low temperature.
Animal models of cartilage repair
Authors: Cook J. L. , Hung C. T. , Kuroki K. , Stoker A. M. , Cook C. R. , Pfeiffer F. M. , Sherman S. L. , Stannard J. P. 
Published: April 2014

Cartilage repair in terms of replacement, or regeneration of damaged or diseased articular cartilage with functional tissue, is the ‘holy grail’ of joint surgery. A wide spectrum of strategies for cartilage repair currently exists and several of these techniques have been reported to be associated with successful clinical outcomes for appropriately selected indications. However, based on respective advantages, disadvantages, and limitations, no single strategy, or even combination of strategies, provides surgeons with viable options for attaining successful long-term outcomes in the majority of patients. As such, development of novel techniques and optimisation of current techniques need to be, and are, the focus of a great deal of research from the basic science level to clinical trials. Translational research that bridges scientific discoveries to clinical application involves the use of animal models in order to assess safety and efficacy for regulatory approval for human use. This review article provides an overview of animal models for cartilage repair. Cite this article: Bone Joint Res 2014;4:89–94.
Iteration schema for common fixed points of nonlinear mappings in spaces of nonpositive curvature
Authors: Khan Muhammad Aqeel Ahmad 
Published: April 2014

Abstract.In this paper, we propose a one-step iteration for the approximation of common fixed points of two uniformly continuous total asymptotically quasi-nonexpansive mappings in uniformly convex hyperbolic spaces. We establish strong convergence and Δ-convergence results of the proposed iteration in this setting. As a consequence, our convergence results improve and generalize various results announced in the current literature.
Refined global Gan–Gross–Prasad conjecture for Bessel periods
Authors: Liu Yifeng 
Published: April 2014

Abstract
We formulate a refined version of the global Gan–Gross–Prasad conjecture
for general Bessel models, extending the work of Ichino–Ikeda and R. N. Harris
in the co-rank 1 case. It is an explicit formula relating the automorphic
period of Bessel type and the central value of certain L-function. To
support such conjecture, we provide two examples for pairs

SO
5

×

SO
2

$\operatorname{SO}_{5}\times\operatorname{SO}_{2}$

and

SO
6

×

SO
3

$\operatorname{SO}_{6}\times\operatorname{SO}_{3}$

(both co-rank 3) in the endoscopic case via theta
lifting.
Donaldson–Thomas invariants and flops
Authors: Calabrese John 
Published: April 2014

Abstract
We prove a comparison formula for the Donaldson–Thomas curve-counting invariants of two smooth and projective Calabi–Yau threefolds related by a flop.
By results of Bridgeland any two such varieties are derived equivalent.
Furthermore there exist pairs of categories of perverse coherent sheaves on both sides which are swapped by this equivalence.
Using the theory developed by Joyce we construct the motivic Hall algebras of these categories.
These algebras provide a bridge relating the invariants on both sides of the flop.
Surprise and humor in product design
Authors: Ludden Geke D. S. , Kudrowitz Barry M. , Schifferstein Hendrik N. J. , Hekkert Paul 
Published: April 2014

AbstractWhen information from two or more sensory modalities conflicts, this can evoke a surprise reaction as well as feelings of amusement, interest, confusion or disappointment. In concurrence to joke theory, we argue that people appreciate and enjoy appropriate incongruities that can be related back to the product, whereas they are confused by and have negative opinions towards inappropriate incongruities.This paper reports the design and the evaluation of products in two categories (rubber duckies and deodorants), with (in)appropriate sensory incongruities of three types: visual-tactual, visual-olfactory and visual-auditory. Participants evaluated the level of surprise felt and the intensity of resulting emotions. They also indicated their overall liking for the products.Both appropriate and inappropriate incongruities were evaluated as surprising as well as confusing. As expected, appropriate incongruities evoked more amusement and were generally favored. Whereas products with visual-tactual incongruities showed large differences in ratings on liking and amusement between appropriate and inappropriate incongruities, these differences were smaller for products with visual-auditory and visual-olfactory incongruities. Possibly, the appropriateness of an incongruity is more conspicuous when it is brought about by a conflict between touch and vision than when olfaction or audition are involved.