bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brefeldin A Limits N‐Hexanoylsphingosine‐Induced Accumulation of Natural Ceramide via the Salvage Pathway by Enhancing Glucosylation
Authors: Spinedi Angelo 
Published: November 2013

AbstractCells actively metabolize exogenously administered N‐hexanoylsphingosine (C6‐Cer) to natural (i.e. long‐chain) ceramide (LC‐Cer) via the sphingosine (Sph) salvage pathway, namely via C6‐Cer deacylation and Sph reacylation with a long‐chain fatty acid. Based on the observation that the mycotoxin brefeldin A (BFA), a Golgi complex disassembler, impairs C6‐Cer‐evoked LC‐Cer accumulation, it has been hypothesized that the integrity of the above‐mentioned organelle might be necessary for C6‐Cer processing via the salvage pathway and that BFA might block the phenomenon at the step short‐chain ceramide deacylation. The present study shows that BFA indeed attenuates C6‐Cer‐evoked LC‐Cer accumulation in human neurotumor CHP‐100 cells: evidence is however provided that the phenomenon is not due to impaired synthesis of LC‐Cer, but to its enhanced conversion to glucosylceramide. The possibility is discussed that this outcome might be a consequence of the BFA well‐established property to induce the merging of the cis‐Golgi region with endoplasmic reticulum, namely the compartments in which glucosylceramide synthase and ceramide synthases have been reported to reside.
Synthesis and Characterization of Novel Diol, Diacid and Di‐isocyanate from Oleic Acid
Authors: Raghunanan Latchmi , Yue Jin , Narine Suresh S. 
Published: November 2013

AbstractNovel linear diol 2, diacid 3, and diisocyanate 4 with functional groups located at each end of the chain have been produced from oleic acid via a diester precursor. All the compounds were fully characterized by IR, 1H NMR, 13C NMR and Mass Spectrometry. These unbranched terminally‐functionalized compounds are important monomers for the manufacture of biodegradable thermoplastic polyurethanes and polyesters. The general synthetic scheme should also prove useful for the syntheses of diols, diacids and diisocyanates from any unsaturated fatty acid.
The Passion of the Passacaille: Ravel, Wagner,Parsifal
Authors: PURI MICHAEL J. 
Published: November 2013

AbstractLong considered to lie ‘light years’ apart, Ravel and Wagner actually have multiple points of contact. Several appear in the comments Ravel made about the German composer in his articles, interviews and correspondence. Another is a previously unrecognised allusion toParsifalin the Passacaille of Ravel's Trio (1914), which he composed shortly after writing a review of the opera's premiere in Paris. Additional Wagnerisms can be located inDaphnis et Chloé(1909–12) andL'Enfant et les sortilèges(1920–5). More broadly, Wagner plays a central role in the ‘decadent dialectics’ of Ravel's style.
Ultrastructure of the Excretory Organs ofBombus morio(Hymenoptera: Bombini): Bee Without Rectal Pads
Authors: Gonçalves Wagner Gonzaga , Fialho Maria do Carmo Queiroz , Azevedo Dihego Oliveira , Zanuncio José Cola , Serrão José Eduardo 
Published: November 2013

AbstractBumblebees need to keep bodily homeostasis and for that have an efficient system of excretion formed by the Malpighian tubules, ileum, and rectum. We analyzed the excretory organs ofBombus morio, a bee without rectal pads. In addition, we analyzed the rectal epithelium ofMelipona quadrifasciata anthidioideswhich has rectal pads. The Malpighian tubules exhibited two cell types and the ileum four types. However, comparative analysis of the rectum showed that only cells of the anterior region of the rectal epithelium ofB. morioare structurally distinct. We suggest that cells of the Malpighian tubules ofB. moriohave an excretory feature and that cells of ileum have different functions, such as ion absorption and water, organic compound, and protein secretion. In addition, only the anterior region of the rectum ofB. morioshowed characteristic absorption. We suggest that Malpighian tubules participate in the excretion of solutes and that the ileum and rectal epithelium are responsible for homeostasis of water and solutes, compensating for the absence of rectal papillae. These results contribute to our understanding of the morphophysiology of the excretory organs of bees without rectal pads.
Quantifying the Digital Traces of Hurricane Sandy on Flickr
Authors: Preis Tobias , Moat Helen Susannah , Bishop Steven R. , Treleaven Philip , Stanley H. Eugene 
Published: November 2013

AbstractSociety’s increasing interactions with technology are creating extensive “digital traces” of our collective human behavior. These new data sources are fuelling the rapid development of the new field of computational social science. To investigate user attention to the Hurricane Sandy disaster in 2012, we analyze data from Flickr, a popular website for sharing personal photographs. In this case study, we find that the number of photos taken and subsequently uploaded to Flickr with titles, descriptions or tags related to Hurricane Sandy bears a striking correlation to the atmospheric pressure in the US state New Jersey during this period. Appropriate leverage of such information could be useful to policy makers and others charged with emergency crisis management.
Exploiting imperfections in the bulk to direct assembly of surface colloids
Authors: Cavallaro Marcello , Gharbi Mohamed A. , Beller Daniel A. , Čopar Simon , Shi Zheng , Baumgart Tobias , Yang Shu , Kamien Randall D. , Stebe Kathleen J. 
Published: November 2013

SignificanceIn this research, we develop new means of directing colloids at an interface to assemble into complex configurations by exploiting defects in a liquid crystal (LC). Through confinement of a nematic LC over a topographically patterned surface, we demonstrate the formation of defects at precise locations in the LC bulk. These defects source elastic distortion fields that guide the assembly of colloids constrained to the LC–air interface. This work significantly extends prior work in which LCs confined in film or droplet geometries guide colloidal assembly beyond simple triangular lattices and chains. Here, we demonstrate colloidal assembly at precise locations, with particle-rich and -poor regions, determined remotely by defects deliberately seeded in the LC bulk. Experimental results are supported by numerical and analytical investigation.
Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X
Authors: Micoli Francesca , Romano Maria Rosaria , Tontini Marta , Cappelletti Emilia , Gavini Massimiliano , Proietti Daniela , Rondini Simona , Swennen Erwin , Santini Laura , Filippini Sara , Balocchi Cristiana , Adamo Roberto , Pluschke Gerd , Norheim Gunnstein , Pollard Andrew , Saul Allan , Rappuoli Rino , MacLennan Calman A. , Berti Francesco , Costantino Paolo 
Published: November 2013

SignificanceMeningococcal serogroup X has recently emerged as a cause of meningitis outbreaks with epidemic potential in sub-Saharan Africa. Novel conjugation technologies, compatible with a reproducible production process, have been successfully used to develop immunogenic polysaccharide conjugate vaccine candidates that are likely to protect against meningococcal X disease. The timely development of an anti-meningococcal X conjugate vaccine appears a logical next step in the broadest control of meningococcal disease and requires commitment now.
Colloidal analogs of molecular chain stoppers
Authors: Klinkova Anna , Thérien-Aubin Héloïse , Choueiri Rachelle M. , Rubinstein Michael , Kumacheva Eugenia 
Published: November 2013

Significance
Self-assembly of nanoparticles in polymer-like chains bears a strong similarity to polymerization reactions, in which monomer units are brought together by directional noncovalent interactions. Based on this similarity, the molecular concepts of polymer chemistry can be applied to achieve controllable nanoparticle assembly. On the other hand, the ability to visualize nanoparticle assemblies and to exploit characterization tools used in nanoscience offers a unique way to study polymerization reactions. Here we explore this twofold strategy for an exemplary system including the self-assembly of bifunctional metal nanorods in the presence of monofunctional nanoparticles (chain stoppers). The approach provided insight into the polymerization kinetics, side reactions, the distribution of species in the system, and the design rules for the synthesis of molecular chain stoppers.
Genome rearrangements caused by interstitial telomeric sequences in yeast
Authors: Aksenova Anna Y. , Greenwell Patricia W. , Dominska Margaret , Shishkin Alexander A. , Kim Jane C. , Petes Thomas D. , Mirkin Sergei M. 
Published: November 2013

Significance
Telomeres are composed of simple repetitive DNA sequences that normally are located at the ends of the chromosomes. Occasionally, however, they also are found inside chromosomes. Some of these internal or interstitial telomeric sequences colocalize with chromosomal fragile sites, preferred sites of breakage in some cancers and hereditary human diseases. The mechanisms responsible for genome instability at interstitial telomeric sequences are unclear. We developed a system to study genetic instabilities caused by these sequences in a model organism (baker’s yeast) that allowed us to characterize various chromosomal rearrangements and to measure the likelihood of their formation. We found that interstitial telomeric sequences promote the formation of deletions, duplications, inversions, and translocations, and we proposed molecular mechanisms responsible for these events.
Long-term inhibitory plasticity in visual cortical layer 4 switches sign at the opening of the critical period
Authors: Lefort Sandrine , Gray Annette C. , Turrigiano Gina G. 
Published: November 2013

Significance
Brain development is characterized by critical periods (CPs) during which neural circuitry is especially sensitive to experience. The changes in cellular plasticity mechanisms that distinguish these CPs from other developmental windows and how these windows open and close remain poorly understood. Here we show that the opening of the classical visual system CP is characterized by a switch in sign of synaptic plasticity at a class of GABAergic synapse known to be important for CP timing.
Model-based clustering for RNA-seq data
Authors: Si Yaqing , Liu Peng , Li Pinghua , Brutnell Thomas P. 
Published: November 2013

Abstract
Motivation: RNA-seq technology has been widely adopted as an attractive alternative to microarray-based methods to study global gene expression. However, robust statistical tools to analyze these complex datasets are still lacking. By grouping genes with similar expression profiles across treatments, cluster analysis provides insight into gene functions and networks, and hence is an important technique for RNA-seq data analysis.
Results: In this manuscript, we derive clustering algorithms based on appropriate probability models for RNA-seq data. An expectation-maximization algorithm and another two stochastic versions of expectation-maximization algorithms are described. In addition, a strategy for initialization based on likelihood is proposed to improve the clustering algorithms. Moreover, we present a model-based hybrid-hierarchical clustering method to generate a tree structure that allows visualization of relationships among clusters as well as flexibility of choosing the number of clusters. Results from both simulation studies and analysis of a maize RNA-seq dataset show that our proposed methods provide better clustering results than alternative methods such as the K-means algorithm and hierarchical clustering methods that are not based on probability models.
Availability and implementation: An R package, MBCluster.Seq, has been developed to implement our proposed algorithms. This R package provides fast computation and is publicly available at http://www.r-project.org.
Contact: sy@swufe.edu.cn; pliu@iastate.edu
Supplementary Information: Supplementary data are available at Bioinformatics online.
Phylowood: interactive web-based animations of biogeographic and phylogeographic histories
Authors: Landis Michael J. , Bedford Trevor 
Published: November 2013

Abstract
Summary: Phylowood is a web service that uses JavaScript to generate in-browser animations of biogeographic and phylogeographic histories from annotated phylogenetic input. The animations are interactive, allowing the user to adjust spatial and temporal resolution, and highlight phylogenetic lineages of interest.
Availability and implementation: All documentation and source code for Phylowood is freely available at https://github.com/mlandis/phylowood, and a live web application is available at https://mlandis.github.io/phylowood.
Contact: mlandis@berkeley.edu
George Chastelain and the Language of Burgundian Historiography
Authors: Strøm-Olsen Rolf 
Published: November 2013

Abstract
The court chronicler George Chastelain developed a complex language to express the interests of his patron, the Burgundian Duke Philip the Good (and, later, Charles the Bold), in establishing increased independence from the French crown. Because the duke was legally beholden to the crown by vassalage, this involved crafting a lexical strategy in which the French king was diminished, even as the ideal of French kingship remained intact, and even glorified, and is suggestive of the two-bodies theory of medieval jurisprudence. Chastelain's strategy can be discerned in specific words and phrases that he uses in conjunction with the French crown; it can also be seen in his reformulation of the traditional organological metaphor of state. In general, this effort was an attempt to address the question of power and legitimacy indirectly, through the tenets of the res publica, without tarnishing the image of French kingship itself.
Simulator Training Enhances Resident Performance in Transesophageal Echocardiography
Authors: Ferrero Natalie A. , Bortsov Andrey V. , Arora Harendra , Martinelli Susan M. , Kolarczyk Lavinia M. , Teeter Emily C. , Zvara David A. , Kumar Priya A. 
Published: November 2013

Abstract

Background:
Standardized training via simulation as an educational adjunct may lead to a more rapid and complete skill achievement. The authors hypothesized that simulation training will also enhance performance in transesophageal echocardiography image acquisition among anesthesia residents.

Methods:
A total of 42 clinical anesthesia residents were randomized to one of two groups: a control group, which received traditional didactic training, and a simulator group, whose training used a transesophageal echocardiography–mannequin simulator. Each participating resident was directed to obtain 10 commonly used standard views on an anesthetized patient under attending supervision. Each of the 10 selected echocardiographic views were evaluated on a grading scale of 0 to 10, according to predetermined criteria. The effect of the intervention was assessed by using a linear mixed model implemented in SAS 9.3 (SAS Institute Inc., Cary, NC).

Results:
Residents in the simulation group obtained significantly higher-quality images with a mean total image quality score of 83 (95% CI, 74 to 92) versus the control group score of 67 (95% CI, 58 to 76); P = 0.016. On average, 71% (95% CI, 58 to 85) of images acquired by each resident in the simulator group were acceptable for clinical use compared with 48% (95% CI, 35 to 62) in the control; P = 0.021. Additionally, the mean difference in score between training groups was the greatest for the clinical anesthesia-1 residents (difference 24; P = 0.031; n = 7 per group) and for those with no previous transesophageal echocardiography experience (difference 26; P = 0.005; simulator n = 13; control n = 11).

Conclusion:
Simulation-based transesophageal echocardiography education enhances image acquisition skills in anesthesiology residents.
Impact of media on stock returns: an in-depth empirical study in China
Authors: Zhang Yahui , Wan Difang , Fu Leiming 
Published: November 2013

Purpose
– Media-effect refers to the phenomenon that stocks with no or low media coverage earn higher returns than stocks with high coverage. This paper aims to explore the existence of media-effect in China stock market and tests the two competing hypotheses explaining this phenomenon.

Design/methodology/approach
– The authors construct a research sample based on a media-coverage event: the publications of lists of the most wealthy Chinese individuals; in addition, they identify the stocks of which listed firms are led by a controller who is recognized on the publicized lists. This paper uses event study methodology to test the existence of media effect in China A-share market. The authors employed propensity score matching (PSM) to construct a control group with same number of non-listed stocks. Then compared the returns of the two portfolios to test the risk premium hypothesis, and the abnormal trading volume and price reaction around the event date is explored to test the over-attention underperformance hypothesis.

Findings
– Sampled stocks show significantly negative abnormal returns within the event period, but the matched control group formed by PSM shows no significant abnormal return, indicating that the risk premium hypothesis is not supported. Covered stocks show significantly magnified trading volume. The portfolio gains significant positive return before the event date but turns significantly negative afterward, which is consistent with the over-attention underperformance hypothesis.

Originality/value
– This paper offers insights into media-effect in China stock market and provides empirical evidence explaining its existence.
Alcohol and violence – exploring the relationship
Authors: Smyth Catherine 
Published: November 2013

Purpose
– Concerns about the alcohol – violence correlation are increasing and impacting on social policy in the UK and throughout the world. It is not certain, however, how much, or if at all, violence is linked to alcohol consumption. The purpose of this paper is to contest often widely held notions and accepted views about alcohol-related violence and to highlight a belief that the link between the two is much more complex than it is sometimes portrayed.

Design/methodology/approach
– Review and analysis of the recent literature.

Findings
– Many studies throughout the literature claim to evidence a biological or pharmacological explanation for the relationship between alcohol and violence in terms of the effect alcohol has on the central nervous system and ensuing behaviour. Other authors who focused on the fact that the relationship may be mediated by all kinds of other personal, social, environmental and cultural factors argue that the effects of alcohol depend upon the social context in which the drinking occurs. From this analysis, four main perspectives and subsequent theories emerge which appear to define the concept.

Originality/value
– By challenging what is often seen by some as a mechanistic causal link between alcohol and violence, clinicians and other professionals working with those individuals affected by alcohol dependence can suggest interventions that help perpetrators of violence work towards addressing their aggression that are not necessarily dependent upon how successful they are in reducing their alcohol consumption.
Inter-industry job mobility in the knowledge economy in Finland
Authors: Mukkala Kirsi , Tohmo Timo 
Published: November 2013

Purpose
– The purpose of this paper is to investigate inter-industry labor mobility, paying special attention to workers who move into high-tech (HT) sectors or knowledge-intensive business services (KIBSs). This study inquires whether skilled workers are mobile and whether the characteristics of mobile workers support the effective transfer of knowledge across industries.

Design/methodology/approach
– Census data representing 7 percent of Finnish residents were used. The micro-econometric estimation method with correction of sample selection bias was applied.

Findings
– The results show that young workers are the most mobile, whereas mobility decreased for those with previous work experience, higher education and higher income level. These findings indicate that the highly skilled workers are not necessarily the most mobile, a trend that may weaken the effectiveness of knowledge spillover. However, on average, highly educated workers move into KIBS sectors more often than to other sectors, and HT sectors attract workers who have higher incomes, which may indicate that their skills are highly valued. As a result, knowledge spillovers may emerge. The knowledge spillovers resulting from job mobility are concentrated in large growth centers that have universities.

Originality/value
– This study provides a new and topical viewpoint to the mobility literature by focussing on skilled workers and their movement toward the HT and KIBS sectors.
Responsible downsizing strategy as a panacea to firm performance: the role of dynamic capabilities
Authors: Cheng-Fei Tsai Philip , Shih Chih-Ting 
Published: November 2013

Purpose– A subject of continuous debate in the field of organizational change research and management practices is on whether downsizing strategies result in improved firm performance. The purpose of this paper is to propose and empirically examine dynamic firm capabilities as a major missing mechanism of firm performance.Design/methodology/approach– This study uses the data of 154 Taiwanese firms that employed an organizational downsizing strategy as the sample for testing the research question.Findings– The results indicate that a responsible downsizing strategy can result in greater firm performance for the development and enhancement of dynamic firm capabilities.Originality value– This research introduces dynamic capabilities into the downsizing context, and the empirical results provide new theoretical insight into downsizing and dynamic capabilities research, suggesting that downsizing should be regarded by management as resource management rather than a cost-cutting action.
Innovation and Chinese HRM research and practice
Authors: G. Wang Greg , Lamond David , Zhang Yichi 
Published: November 2013

Purpose– This article aims to highlight the importance of creativity and innovation in Chinese HRM research and practice. The authors first seek to bring some conceptual clarity to the term “innovation”, especially in relation to the notion of creativity. The authors then discuss Chinese HRM research and policies and practices associated with innovation. The authors conclude the article by introducing the forum articles that constitute this issue of the journal.Design/methodology/approach– Literature review and analysis.Findings– The authors discuss the conceptual difference and similarity between innovation and creativity. The literature analysis shows that Chinese HRM research is in a transitioning stage from local private novelty to global novelty, and innovation at individual and organizational level is determined by a sound national innovation system (NIS) that either fosters or hinders the overall ability of innovation in a sub-system.Originality/value– The article differentiates creativity and innovation conceptually and specifies the critical role of NIS in fostering innovation ability at individual and organizational levels.