bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sources and geodynamic setting of petrogenesis of the Middle Cambrian Upper Petropavlovka alkaline basic pluton (Kuznetsk Alatau, Siberia)
Authors: Vrublevskii V.V. 
Published: March 2015

Abstract
Early Paleozoic alkaline basic magmatism in the Kuznetsk Alatau is manifested in the Upper Petropavlovka pluton of gabbro, feldspathoid rocks (theralites, mafic foidolites, and nepheline syenites), and Ca-carbonatites. According to Sm–Nd and Rb–Sr isotope data, the pluton formed in the Middle Cambrian (509 ± 10 Ma). The silicate igneous rocks correspond in the contents of silica, alumina, and alkalies to derivates of a K–Na alkaline basic association. The Ca-carbonatites are characterized by a high-temperature (600–900 °C) paragenesis of apatite, clinopyroxene, ferromonticellite, phlogopite, and magnetite. They are enriched in P2O5 (up to 6.4 wt.%), Sr (up to 3000–4500 ppm; Sr/Ba ~ 5–7), and REE + Y (up to 800 ppm) and show evidence for liquation genesis. The predominant magmatic source (εNd(T) = 5–7) was moderately depleted PREMA, possibly combined with E-MORB and EM. According to the isotopic data ((87Sr/86Sr)T ~ 0.7024–0.7065; δ18O ~ 6.3–15.5‰; δ18C ~ –3.5 to –2.0‰), the fractionation of the melts was accompanied by their crustal contamination. The trace-element composition of the mafic rocks testifies to the participation of a substance similar to the substrata of the parental magmas of MORB, IAB, and OIB in the magma generation. This suggests intrusion in the geodynamic setting of interaction between the active continental margin and an ascending mantle diapir. Most likely, the intrusion led to the mixing of material from different sources, including the components of PREMA, enriched suprasubduction lithospheric mantle (EM), and continental crust. The assumption is made that the complexes of highly alkaline rocks and carbonatites in the western Central Asian Fold Belt are of plume origin and belong to an Early Paleozoic large igneous province.
The Zhireken porphyry Mo ore-magmatic system (eastern Transbaikalia): U–Pb age, sources, and geodynamic setting
Authors: Berzina A.P. , Berzina A.N. , Gimon V.O. , Bayanova T.B. , Kiseleva V.Yu. , Krymskii R.Sh. , Lepekhina E.N. , Palesskii S.V. 
Published: March 2015

Abstract
Two intrusive complexes are recognized in the Zhireken deposit: Amanan and ore-bearing porphyry. According to the ages obtained by U–Pb zircon dating (Amanan complex—162.6 ± 1.4 Ma, granites and monzonite-porphyry of the ore-bearing complex—159.0 ± 1.6 and 157.5 ± 2.9 Ma), the Amanan complex formed at the end of collision, and the ore-bearing porphyry complex, during the change of the geodynamic regime by the postcollisional (rift) one. The rocks of two complexes have high contents of LILE and LREE and low contents of HFSE and HREE. The (87Sr/86Sr)0 ratio in the gabbro and granites of the Amanan complex is 0.70501 and 0.70534, respectively, and that in the rocks of the porphyry complex is within 0.70451–0.70633. The Amanan gabbro, gabbro-diorites, and granites are characterized by εNd(T) = –1.4, –1.8, and –10.3, respectively, and the rocks of the ore-bearing complex, by εNd(T) = –3.7 to + 1.0. The model TNd(DM) age of the Amanan granites is 1.5 Ga, and that of the granites and porphyry of the ore-bearing complex is 1.0–0.8 Ga. The Pb isotope ratios in the rocks of the Amanan and porphyry complexes are: 206Pb/204Pb = 18.086–18.136 and 18.199–18.442, 207Pb/204Pb = 15.487–15.499 and 15.506–15.545, and 208Pb/204Pb = 38.046–38.256 and 38.230–38.456. The results of geological, geochemical, and isotope studies admit that magmas were generated from juvenile and ancient crusts. Melts probably ascended from a depth of no less than 55 km during the melting of crust thickened as a result of tectonic deformations (in the upper horizons) and during the basic-magma supply (in the lower horizons). Juvenile mafic crust is considered to be the major source of fluid components and metals. Favorable conditions for the ore generation in the magmatic system during the formation of the porphyry complex arose at the previous stage, during the formation of the Amanan complex, which we regard as a preparatory stage in the evolution of the long-living ore-magmatic system.
© 2015, V.S. Sobolev IGM, Siberian Branch of the RAS. Published by Elsevier B.V. All rights reserved.
The nature of geomagnetic anomalies in metamorphosed chromite-bearing dunites: a case study of the southern Klyuchevskoy complex, Central Urals
Authors: Sherendo T.A. , Vdovin A.G. , Martyshko P.S. , Mitrofanov V.Ya. , Alekseev A.V. , Zamyatin D.A. , Vazhenin V.A. , Pamyatnykh L.A. 
Published: March 2015

Abstract
Chromite mineralization in metamorphosed dunites from the southern Klyuchevskoy dunite-harzburgite ultramafic complex (Central Urals) has been investigated using geomagnetic surveys along with laboratory studies of ore-forming and accessory spinels of the same genetic type. Magnetization in the study area is carried mainly by accessory Fe-Cr-spinel of a variable Fe2+(Cr2-xFex3+)O4 composition. Metamorphism caused changes in element contents and in both crystal and magnetic structure of the primary nonmagnetic accessory spinel, unlike the almost fresh ore-forming spinel. Thus, ore bodies stand against their host rocks, which is a prerequisite for the use of geomagnetic surveys for exploration of podiform chromite deposits in dunite-harzburgite complexes. Ground magnetic surveys at a test site composed of faulted rocks bearing disseminated chromite mineralization in metamorphosed dunites resolved a chromite ore zone and a fault block boundary showing up as geomagnetic anomalies. Laboratory studies using high technologies (thermomagnetic analysis at 4 to 1000 K, as well as magnetic resonance and magnetic force spectroscopy) revealed, for the first time, magnetic clusters (superparamagnetic phases) in primary nonmagnetic accessory spinel, which are responsible for the magnetic properties of the host rocks. Microscale variations in Cr-spinel correlate with the geomagnetic anomalies recorded by field surveys at the test site.
© 2015, V.S. Sobolev IGM, Siberian Branch of the RAS. Published by Elsevier B.V. All rights reserved.
VisualCNA: a GUI for interactive constraint network analysis and protein engineering for improving thermostability
Authors: Rathi Prakash Chandra , Mulnaes Daniel , Gohlke Holger 
Published: March 2015

Abstract
Summary: Constraint network analysis (CNA) is a graph theory-based rigidity analysis approach for linking a biomolecule’s structure, flexibility, (thermo)stability and function. Results from CNA are highly information-rich and require intuitive, synchronized and interactive visualization for a comprehensive analysis. We developed VisualCNA, an easy-to-use PyMOL plug-in that allows setup of CNA runs and analysis of CNA results linking plots with molecular graphics representations. From a practical viewpoint, the most striking feature of VisualCNA is that it facilitates interactive protein engineering aimed at improving thermostability.
Availability and Implementation: VisualCNA and its dependencies (CNA and FIRST software) are available free of charge under GPL and academic licenses, respectively. VisualCNA and CNA are available at http://cpclab.uni-duesseldorf.de/software; FIRST is available at http://flexweb.asu.edu.
Contact: gohlke@uni-duesseldorf.de
Success criteria for electronic medical record implementations in low-resource settings: a systematic review
Authors: Fritz Fleur , Tilahun Binyam , Dugas Martin 
Published: March 2015

Abstract
Objective Electronic medical record (EMR) systems have the potential of supporting clinical work by providing the right information at the right time to the right people and thus make efficient use of resources. This is especially important in low-resource settings where reliable data are also needed to support public health and local supporting organizations. In this systematic literature review, our objectives are to identify and collect literature about success criteria of EMR implementations in low-resource settings and to summarize them into recommendations.
Materials and Methods Our search strategy relied on PubMed queries and manual bibliography reviews. Studies were included if EMR implementations in low-resource settings were described. The extracted success criteria and measurements were summarized into 7 categories: ethical, financial, functionality, organizational, political, technical, and training.
Results We collected 381 success criteria with 229 measurements from 47 articles out of 223 articles.
Most papers were evaluations or lessons learned from African countries, published from 1999 to 2013. Almost half of the EMR systems served a specific disease area like human immunodeficiency virus (HIV). The majority of criteria that were reported dealt with the functionality, followed by organizational issues, and technical infrastructures. Sufficient training and skilled personnel were mentioned in roughly 10%. Political, ethical, and financial considerations did not play a predominant role. More evaluations based on reliable frameworks are needed.
Conclusions Highly reliable data handling methods, human resources and effective project management, as well as technical architecture and infrastructure are all key factors for successful EMR implementation.
Standard for improving emergency information interoperability: the HL7 data elements for emergency department systems
Authors: McClay James C , Park Peter J , Janczewski Mark G , Langford Laura Heermann 
Published: March 2015

Abstract
Background Emergency departments in the United States service over 130 million visits per year. The demands for information from these visits require interoperable data exchange standards. While multiple data exchange specifications are in use, none have undergone rigorous standards review. This paper describes the creation and balloting of the Health Level Seven (HL7) Data Elements for Emergency Department Systems (DEEDS).
Methods Existing data exchange specifications were collected and organized into categories reflecting the workflow of emergency care. The concepts were then mapped to existing standards for vocabulary, data types, and the HL7 information model. The HL7 community then processed the specification through the normal balloting process addressing all comments and concerns. The resulting specification was then submitted for publication as an HL7 informational standard.
Results The resulting specification contains 525 concepts related to emergency care required for operations and reporting to external agencies. An additional 200 of the most commonly ordered laboratory tests were included. Each concept was given a unique identifier and mapped to Logical Observation Identifiers, Names, and Codes (LOINC). HL7 standard data types were applied.
Discussion The HL7 DEEDS specification represents the first set of common ED related data elements to undergo rigorous standards development. The availability of this standard will contribute to improved interoperability of emergency care data.
Feasibility and acceptability of a remotely administered computerized intervention to address cognitive late effects among childhood cancer survivors
Authors: Cox Lauren E. , Ashford Jason M. , Clark Kellie N. , Martin-Elbahesh Karen , Hardy Kristina K. , Merchant Thomas E. , Ogg Robert J. , Jeha Sima , Willard Victoria W. , Huang Lu , Zhang Hui , Conklin Heather M. 
Published: March 2015

Abstract

Background
Childhood cancer survivors frequently develop working memory (WM) deficits as a result of disease and treatment. Medication-based and therapist-delivered interventions are promising but have limitations. Computerized interventions completed at home may be more appealing for survivors. We evaluated the feasibility and acceptability of a remotely administered, computerized WM intervention (Cogmed) for pediatric cancer survivors using a single-blind, randomized, wait-list control design.

Methods
Of 80 qualifying patients, 12 were excluded or declined to participate. Participants randomized to intervention (n = 34/68) included survivors of childhood brain tumors (32%) or acute lymphoblastic leukemia (ALL; 68%) between the ages of 8 and 16 years (x¯ = 12.2) who were at least 1 year post therapy (x¯ = 5.0). The majority of brain tumor participants were treated with cranial radiation therapy (72.7%), whereas most of the ALL participants were treated with chemotherapy only (87%). Participants completed 25 WM training sessions over 5–9 weeks at home with weekly phone-based coaching.

Results
Participants lived in 16 states. Compliance was strong, with 30 of the 34 participants (88%) completing intervention. Almost all participants completed pre- and postintervention neuroimaging exams (91% and 93%, respectively). Families had the necessary skills to utilize the computer program successfully. Caregivers reported they were generally able to find time to complete training (63%), viewed training as beneficial (70%), and would recommend this intervention to others (93%).

Conclusions
Cogmed is a feasible and acceptable intervention for childhood cancer survivors. It is a viable option for survivors who do not live in close proximity to cancer care centers. Efficacy and neural correlates of change are currently being evaluated.
Adherence to Antihypertensive Medication in Older Adults With Hypertension
Authors: Lo Suzanne H. S. , Chau Janita P. C. , Woo Jean , Thompson David R. , Choi Kai Chow 
Published: March 2015

Background/Objectives:
Effective prevention of cardiovascular events in people with hypertension requires optimal control of blood pressure. Despite advances in management, poor adherence to antihypertensive medications is often reported as the major reason attenuating treatment efficacy. Research has provided limited evidence of associations between illness perceptions, satisfaction with consultations, and medication adherence. The aim of this study is to identify factors significantly associated with medication adherence in a group of Chinese older adults with essential hypertension.

Design/Setting/Participants:
A cross-sectional correlational study was conducted. Data were collected from 195 older adults (mean [SD] age, 76 [6.6] years) recruited from 12 community centers.

Measurements:
The Illness Perception Questionnaire–Revised was used to measure illness perceptions, and the Medical Interview Satisfaction Scale was used to measure satisfaction with individual consultations. The Morisky Medication Adherence Scale was used to measure the extent of adherence to antihypertensive medications. Multivariate logistic regression analysis was performed to examine factors, including illness perceptions, consultation satisfaction, and demographic and clinical characteristics, that were significantly associated with medication adherence.

Results:
More than half of the respondents (55.9%) acknowledged some degree of medication nonadherence. Older age, living alone, and perception related to treatment control were independently associated with increased odds of medication adherence, with odds ratios ranging from 1.14 to 1.92 (P < .05).

Conclusion:
The results highlight the importance of cultivating positive beliefs that hypertension is amenable to control by treatment. Furthermore, the adherence behavior of those of younger individuals and living with family should be closely monitored.
Influence of Gender and Age on the Peripheral Immune Response in Stroke
Authors: Ross Amy Miner , Lee Christopher S. , Lutsep Helmi 
Published: March 2015

Background:
Women and men have unique stroke risk factors and can experience different poststroke infections.

Objective:
The aim of this study is to determine the influence of gender, age, and risk factors on the peripheral immune response in stroke/transient ischemic attack (TIA).

Method:
A total of 192 adult acute stroke/TIA cases were analyzed for age, gender, risk factors for stroke/TIA, and white blood cell with differential count. χ
2 Test and analysis of variance were conducted to test for differences between genders and age groups related to stroke risk factors and the immune response. Growth modeling was used to test for trended differences in the immune response.

Results:
Women were 4 years older than men; fewer women had strokes in the younger age group (<79 years) and more men currently smoked. Trended lymphocyte percentages for the young and old (slope, P = .04; pattern, P = .02) and admission monocyte percentages by gender were significantly different (P = .01).

Conclusions:
Age influenced trended lymphocyte numbers and gender influenced monocyte percentage on admission.
Facilitators and Barriers of Heart Surgery Discharge
Authors: Lapum Jennifer L. , Fredericks Suzanne , Liu Linda , Yau Terrence M. , Retta Bruktawit , Jones Vaska M. , Hume Sarah 
Published: March 2015

Background:
Optimal patient recovery from open-heart surgery relies on effective discharge planning and education. However, the nature of the discharge experience has not been clearly described.

Objective:
The study purpose is to explore patients’ and nurses’ narrative accounts of the facilitators and barriers of heart surgery discharge.

Methods:
A qualitative study was employed using a narrative methodology that elicited and analyzed stories. This research was conducted in a large, urban hospital in Ontario, Canada. A total of 17 patients and nurses were recruited. Five female and 5 male patients were recruited from a preoperative clinic. Ages ranged from 37 to 80 years. Seven nurses were recruited from inpatient cardiovascular units. They had 2 to 19 years of cardiovascular nursing experience. Semistructured, narrative-based interviews were conducted. Two interviews were conducted with each patient at 1 week after discharge and at 4 to 6 weeks. One interview was conducted with each nurse.

Results:
Findings indicate that although the preoperative period was identified as an effective time for discharge preparation, the patient’s cognitive capacity was limited during the postoperative phase of surgery. Both nurses and patients also found that insufficient time impeded the discharge process and limited individualized discussions. The structured and standardized delivery of discharge information affected patients’ capacity to apply it to the particularities in their own lives and homes. The fostering of therapeutic relationships created a space where patients felt comfortable sharing their concerns and nurses learned more about patients and thus could better tailor the discharge approach.

Conclusions:
Study recommendations include group and scenario-based education in which patients and nurses brainstorm about how to apply the discharge information to the particularities of patients’ lives and homes. Provision of support needs to be bolstered during the home period, where patients have timely opportunities to discuss their concerns and questions with practitioners or possibly peers.
The Barley Powdery Mildew Candidate Secreted Effector Protein CSEP0105 Inhibits the Chaperone Activity of a Small Heat Shock Protein
Authors: Ahmed Ali Abdurehim , Pedersen Carsten , Schultz-Larsen Torsten , Kwaaitaal Mark , Jørgensen Hans Jørgen Lyngs , Thordal-Christensen Hans 
Published: March 2015

AbstractPathogens secrete effector proteins to establish a successful interaction with their host. Here, we describe two barley (Hordeum vulgare) powdery mildew candidate secreted effector proteins, CSEP0105 and CSEP0162, which contribute to pathogen success and appear to be required during or after haustorial formation. Silencing of either CSEP using host-induced gene silencing significantly reduced the fungal haustorial formation rate. Interestingly, both CSEPs interact with the barley small heat shock proteins, Hsp16.9 and Hsp17.5, in a yeast two-hybrid assay. Small heat shock proteins are known to stabilize several intracellular proteins, including defense-related signaling components, through their chaperone activity. CSEP0105 and CSEP0162 localized to the cytosol and the nucleus of barley epidermal cells, whereas Hsp16.9 and Hsp17.5 are cytosolic. Intriguingly, only those specific CSEPs changed localization and became restricted to the cytosol when coexpressed with Hsp16.9 and Hsp17.5, confirming the CSEP-small heat shock protein interaction. As predicted, Hsp16.9 showed chaperone activity, as it could prevent the aggregation of Escherichia coli proteins during thermal stress. Remarkably, CSEP0105 compromised this activity. These data suggest that CSEP0105 promotes virulence by interfering with the chaperone activity of a barley small heat shock protein essential for defense and stress responses.
Interpreting immunological indices: The importance of taking parasite community into account. An example in blackbirdsTurdus merula
Authors: Biard Clotilde , Monceau Karine , Motreuil Sébastien , Moreau Jérôme 
Published: March 2015

SummaryDespite the intensive use of immune indices in immunoecology, whether to interpret the results of immune indices in terms of actual immune competence (i.e. ability to control and clear parasite infections as indicated by high values of immune indices associated with low parasite loads) or current immune activation (pathogenic infection being associated with high parasite load and high values of immune indices) is still an open question. Most studies to date have produced contrasting results focused on the effect of a single parasite species despite the fact that hosts usually harbour a community of parasites that influences one another's impact on host immune response.We simultaneously assessed blood parasites, intestinal parasites and ectoparasite loads in male blackbirds and compared these measures to several immune indices to investigate how parasites explain the variation around the mean of these immune indices.Parasite loads covaried within hosts. Immune indices better reflected the interacting effects of these parasites than their independent effect. Immune indices may therefore be better indicators of ongoing pathogenic infections than immunocompetence. Furthermore, intestinal parasites explained a significant part of the variance in most immune indices through their interactions with other parasites, suggesting that they have a strong influence in modulating immune function.Taking the parasite community into account in immunoecology studies will certainly help increase our understanding of immune indices.