bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Grob Fragmentation of 2‐Azabicyclo[2.2.2]oct‐7‐ene: Tool for the Stereoselective Synthesis of Polysubstituted Piperidines.
Authors: Lemonnier Gerald , Charette Andre B. 
Published: October 2012

AbstractThe Grob fragmentation of bicycles (I) or (XVIII) provides highly reactive dihydropyridinium intermediates which react with a variety of organocuprates or other soft nucleophiles in a regio‐ and stereoselective manner to give 2,3,4‐trisubstituted 1,2,3,4‐tetrahydropyridines.
ChemInform Abstract: Three‐Step One‐Pot Synthesis of Imidazo[2,1‐b]chalcogenazoles via Intramolecular Cyclization of N‐Alkynylimidazoles.
Authors: Roehrs Juliano Alex , Pistoia Renan P. , Back Davi F. , Zeni Gilson 
Published: October 2012

AbstractThe generality of the reaction is established with various substituted N‐alkynylimidazoles as well as elemental chalcogens.
ChemInform Abstract: Chiral Phosphine—Phosphoramidite Ligands for Highly Efficient Ir‐Catalyzed Asymmetric Hydrogenation of Sterically Hindered N‐Arylimines.
Authors: Hou Chuan‐Jin , Wang Ya‐Hui , Zheng Zhuo , Xu Jie , Hu Xiang‐Ping 
Published: October 2012

AbstractThe new phosphoramidite efficiently promotes the Ir‐catalyzed asymmetric hydrogenation of a number of sterically hindered N‐arylimines.
ChemInform Abstract: Benzylation of Nitroalkanes Using Copper‐Catalyzed Thermal Redox Catalysis: Toward the Facile C‐Alkylation of Nitroalkanes.
Authors: Gildner Peter G. , Gietter Amber A. S. , Cui Di , Watson Donald A. 
Published: October 2012

AbstractThe in situ generated Cu(I) catalyst is highly effective for C‐benzylation of nitroalkanes via reduction of the benzyl bromides to the corresponding radicals.
ChemInform Abstract: Ligand‐Free Coupling of Phenols and Alcohols with Aryl Halides by a Recyclable Heterogeneous Copper Catalyst.
Authors: Wang Man , Yuan Bizhen , Ma Tongmei , Jiang Huanfeng , Li Yingwei 
Published: October 2012

AbstractThe catalyst can be recovered and reused without any significant loss of activity after three runs.
ChemInform Abstract: Palladium‐Catalyzed Coupling Reactions of (ArCH2)Ti(O‐i‐Pr)3 with Aromatic or Heteroaromatic Bromides.
Authors: Chang Shu‐Ting , Li Qinghan , Chiang Ruei‐Tang , Gau Han‐Mou 
Published: October 2012

AbstractThe novel mild and efficient title reaction is established for a variety of aromatic and heteroaromatic bromides.
ChemInform Abstract: Reaction of N‐Sulfinyltrifluoromethanesulfonamide with Carbodiimides: Formation of N‐Trifluoromethanesulfonyl‐2,4‐dialkyl‐1,2,4‐thiadiazetidin‐3‐imine 1‐Oxides.
Authors: Shainyan Bagrat A. , Tolstikova Ljudmila L. 
Published: October 2012

AbstractAs opposed to the literature data, the title reaction affords thiadiazetidine derivatives (III) by the rearrangement of the initially formed [2π + 2π] cycloadducts via a ring opening—ring closure sequence.
ChemInform Abstract: Approaches to the Construction of Substituted 4‐Amino‐1H‐pyrrol‐2(5H)‐ones.
Authors: Zali‐Boeini Hassan , Mobin Mehdi , Hajibabaei Khadijeh , Ghani Maryam 
Published: October 2012

AbstractThe precursors for the title pyrrole derivatives are prepared via simple routes starting from imines, ketones, or α‐bromophenyl acetonitriles and aq.
ChemInform Abstract: Copper‐Catalyzed Arylation of Tetrazole‐5‐thiones upon Convection Heating and Microwave Activation Conditions.
Authors: Dmitrieva U. N. , Ramsh S. M. , Zevatskii Yu. E. , Artamonova T. V. , Myznikov L. V. 
Published: October 2012

AbstractCompared to convection heating, microwave activation increases product yields at the same reaction time and simplifies product isolation due to reduced for formation.
ChemInform Abstract: Palladium(II)‐Catalyzed Direct Alkenylation of Nonaromatic Enamides.
Authors: Gigant Nicolas , Gillaizeau Isabelle 
Published: October 2012

AbstractThe Pd‐catalyzed treatment of nonaromatic enamides with activated alkenes allows a new, efficient, regio‐ and stereoselective access to C‐3 functionalized enamides.
ChemInform Abstract: Alkylation of Pyridone Derivatives by Nickel/Lewis Acid Catalysis.
Authors: Tamura Ryuichi , Yamada Yuuya , Nakao Yoshiaki , Hiyama Tamejiro 
Published: October 2012

AbstractThe alkylation of a variety of pyridones and pyrimidones with unactivated olefins in the presence of a Ni(0)—NHC—Lewis acid cocatalyst system proceeds with high linear‐to‐branched selectivity and moderate to high regioselectivity (towards position 6 of pyridone).
ChemInform Abstract: Pyridylmagnesiates: Generation by Bromine—Metal Exchange and Enantioselective Addition to Aldehydes.
Authors: Catel Delphine , Payen Olivier , Chevallier Floris , Mongin Florence , Gros Philippe C. 
Published: October 2012

AbstractThis is the first example of enantioselective addition of in situ generated pyridylmagnesiate to carbonyl electrophiles.
ChemInform Abstract: Imidazo[1,2‐a]pyridines Susceptible to Excited State Intramolecular Proton Transfer: One‐Pot Synthesis via an Ortoleva—King Reaction.
Authors: Stasyuk Anton J. , Banasiewicz Marzena , Cyranski Michal K. , Gryko Daniel T. 
Published: October 2012

AbstractUnder optimized conditions, aminopyridine (I) and acetophenones or heterocyclic analogues undergo the Ortoleva—King reaction followed by a ring‐closure of the initially formed pyridinium salts in the presence of an excess of NaOH.
ChemInform Abstract: Synthesis and Antiinflammatory Activity of Imidazo[1,2‐a]pyridinyl/pyrazinyl Benzamides and Acetamides.
Authors: Hemasritlatha S. , Sruthi K. , Manjula A. , Babu V. Harinadha , Rao B. Vittal 
Published: October 2012

AbstractA wide range of title compounds (III) and (V) is prepared by ring opening of oxazole derivatives (I) with the corresponding azaheterocycle.
ChemInform Abstract: Iridium‐Catalyzed, Substrate‐Directed C—H Borylation Reactions of Benzylic Amines.
Authors: Roering Andrew J. , Hale Lillian V. A. , Squier Phillip A. , Ringgold Marissa A. , Wiederspan Emily R. , Clark Timothy B. 
Published: October 2012

AbstractTreatment of benzylic amines as well as phenethylamines and imidazolidine derivatives of type (XII) with the boronate (II) results in selective formation of ortho‐borylated products.
ChemInform Abstract: Stability of Some Aryllithiums in the Presence of Cyano Group: Synthesis of Biaromatic Cyanoarylboronic Acids and Silanes.
Authors: Durka Krzysztof , Gontarczyk Krzysztof , Klis Tomasz , Serwatowski Janusz , Wozniak Krzysztof 
Published: October 2012

AbstractThe increase in the number of fluorine atoms stabilizes the ortho‐lithiated species, cf.
ChemInform Abstract: Synthesis and Structure—Activity Studies of Simplified Analogues of Aplysiatoxin with Antiproliferative Activity Like Bryostatin‐1
Authors: Irie Kazuhiro , Kikumori Masayuki , Kamachi Hiroaki , Tanaka Keisuke , Murakami Akira , Yanagita Ryo C. , Tokuda Harukuni , Suzuki Nobutaka , Nagai Hiroshi , Suenaga Kiyotake , et al. et al. 
Published: October 2012

AbstractReview: 57 refs.
ChemInform Abstract: Indigo and Tyrian Purple — From Ancient Natural Dyes to Modern Organic Semiconductors
Authors: Glowacki Eric Daniel , Voss Gundula , Leonat Lucia , Irimia‐Vladu Mihai , Bauer Siegfried , Sariciftci Niyazi Serdar 
Published: October 2012

AbstractReview: 39 refs.
Directed glia‐assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood‐barrier function
Authors: Farahani Ramin M. , Sarrafpour Babak , Simonian Mary , Li Qing , Hunter Neil 
Published: October 2012

AbstractThe specialized tightly controlled microcirculation of craniofacial neurosensory organs is an essential evolutionary adaptation and yet a dilemma where angiogenic remodeling occurs. Despite extreme plasticity of neurosensory structures, the capacity to reconcile barrier phenotype of the microcirculation with an angiogenic cascade is not known. Here we provide primary evidence for such a response in an elemental neurosensory structure, human dental pulp, following chronic carious insult. In response to hypoxic challenge neurosensory odontoblasts express hypoxia‐inducible factor‐1α and notch‐1. Associated radial rearrangement of astrocyte‐like telacytes that communicate through a cell‐poor zone with the microvasculature is observed. Activated pericytes characterized by expression of α‐smooth muscle actin are located adjacent to the telacyte attachment to the vasculature. In this location, endothelial expression of sonic hedgehog parallels expression of notch‐1 by pericytes. The angiogenic response is initiated by pericyte contraction and altered endothelial polarity and proliferation leading to intussusception of endothelial cells and extensive remodeling of basement membrane with upregulation of laminin‐8 and laminin‐5. These responses guide intravascular loop formation that maintains both intact basement membrane and tight junctions. This initial phase is followed by formation of anastomoses that enhance the hemodynamic capacity of the intravascular loops. The formation of anastomoses is mediated by extension of cytonemes from pericytes guided by MHC‐II+/CD‐163+ microglia aligned with the telacytes. The cytonemes seek out pericytes on adjacent intravascular loops to initiate migration of endothelial cells. These findings support a new paradigm for understanding angiogenic capacity of neurosensory structures and aberrations of this response manifest as neurovasculopathies. J. Comp. Neurol. 520:3803–3826, 2012. © 2012 Wiley Periodicals, Inc.
Genetic and environmental influences on thin‐ideal internalization
Authors: Suisman Jessica L. , O'Connor Shannon M. , Sperry Steffanie , Thompson J. Kevin , Keel Pamela K. , Burt S. Alexandra , Neale Michael , Boker Steven , Sisk Cheryl , Klump Kelly L. 
Published: October 2012

AbstractObjective:Current research on the etiology of thin‐ideal internalization focuses on psychosocial influences (e.g., media exposure). The possibility that genetic influences also account for variance in thin‐ideal internalization has never been directly examined. This study used a twin design to estimate genetic effects on thin‐ideal internalization and examine if environmental influences are primarily shared or nonshared in origin.Method:Participants were 343 postpubertal female twins (ages: 12–22 years; M = 17.61) from the Michigan State University Twin Registry. Thin‐ideal internalization was assessed using the Sociocultural Attitudes toward Appearance Questionnaire‐3.Results:Twin modeling suggested significant additive genetic and nonshared environmental influences on thin‐ideal internalization. Shared environmental influences were small and non‐significant.Discussion:Although prior research focused on psychosocial factors, genetic influences on thin‐ideal internalization were significant and moderate in magnitude. Research is needed to investigate possible interplay between genetic and nonshared environmental factors in the development of thin‐ideal internalization. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
The Development of an Aza‐C‐Glycoside Library Based on a Tandem Staudinger/Aza‐Wittig/Ugi Three‐Component Reaction
Authors: Wennekes Tom , Bonger Kimberly M. , Vogel Katrin , van den Berg Richard J. B. H. N. , Strijland Anneke , Donker‐Koopman Wilma E. , Aerts Johannes M. F. G. , van der Marel Gijsbert A. , Overkleeft Herman S. 
Published: October 2012

AbstractWe report the tandem Staudinger/aza‐Wittig/Ugi three‐component reaction mediated synthesis of a 64‐member compound library of aza‐C‐glycosides. The library is composed of four pyrrolidine and three piperidine scaffolds, onto which a number of functional groups is grafted to form seven sublibraries. Variation in the library is achieved by transformation of two pentoses and a hexose into the corresponding 4‐azidopentanal and 5‐azidohexanal derivatives as precursors for the Staudinger/aza‐Wittig process. Further variation is achieved by using different isocyanides as well as protective‐ and functional‐group manipulations on the fully protected Ugi‐3CR intermediates. Preliminary biological evaluation of the compound library revealed several low micromolar inhibitors of human acid glucosylceramidase.
Genetic variants of p21 and p27 and hepatocellular cancer risk in a Chinese Han population: A case‐control study
Authors: Liu Fei , Wei Yong‐Gang , Luo Li‐Mei , Wang Wen‐Tao , Yan Lv‐Nan , Wen Tian‐Fu , Xu Ming‐Qing , Yang Jia‐Yin , Li Bo 
Published: October 2012

AbstractThe p21 (Cip1/CDKN1A) and p27 (Kip1/CDKN1B) are members of the Cip/Kip family of cyclin‐dependent kinase inhibitors, which can arrest cell proliferation and serve as tumour suppressors. We hypothesized that genetic variants in p21 and p27 may modify individual susceptibility to hepatocellular carcinoma (HCC). To test this hypothesis, we evaluated the associations of the polymorphisms of Ser31Arg and C+20T in p21 and C‐79T and Gly109Val in p27, as well as their combinations, with HCC risk in a case‐control study of 476 HCC cases and 526 cancer‐free controls in a Chinese population. The matrix‐assisted laser desorption ionisation time‐of‐flight (MALDI‐TOF) mass spectrometry method was performed to detect these polymorphisms. We found that the variant genotypes of p21 Ser31Arg and p27 C‐79T were individually associated with a significantly increased risk of HCC, but no associations were observed for other variant genotypes. Moreover, the combined variant genotypes of the four loci were associated with a significantly increased HCC risk (adjusted OR = 2.24, 95% CI = 1.72, 2.91 among subjects carrying 3 or more variant alleles), especially among HbsAg‐positive individuals (adjusted OR = 3.09, 95% CI = 1.86, 5.14). Furthermore, the combined variant genotypes of the four loci (carrying three or more variant alleles) increased a 1.93‐fold (95% CI = 1.20, 3.09) and 1.76‐fold (95% CI = 1.17, 2.64) risk of HCC among smokers and nonsmokers. The variant genotypes of the two genes in this study have negative correlation with the clinicopathologicals observed. These results suggest that p21 polymorphisms individually or in combination with p27 polymorphisms increases risk of HCC, particularly among HbsAg‐positive individuals.
The risk of Barrett's esophagus associated with abdominal obesity in males and females
Authors: Kendall Bradley J. , Macdonald Graeme A. , Hayward Nicholas K. , Prins Johannes B. , O'Brien Suzanne , Whiteman David C. ,   for the Study of Digestive Health
Published: October 2012

AbstractEsophageal adenocarcinoma arises from Barrett's esophagus (BE). Both occur predominantly in males. The role of abdominal obesity in this sex distribution is uncertain. Our study aimed to determine whether there is an association between abdominal obesity and risk of BE and if present was it modified by sex. A structured interview and anthropometric measures were conducted within a population‐based case–control study. We recruited 237 BE cases (70% male) and 247 population controls, frequency matched by age and sex. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression analysis. In the overall group and males, all measures of abdominal obesity [waist circumference (WC), waist–hip ratio (WHR), sagittal abdominal diameter (SAD) and waist–height ratio (WHtR)] were strongly associated with risk of BE (Overall: WC OR 2.2 95% CI 1.4–3.5, WHR 1.8 95% CI 1.2–2.9, SAD 2.3 95% CI 1.4–3.7, WHtR 1.9 95% CI 1.2–3.0, males WC 2.5 95% CI 1.4–4.3, WHR 2.4 95% CI 1.3–4.2, SAD 2.5 95% CI 1.4–4.3, WHtR 1.9 95% CI 1.1–3.4). These associations were minimally attenuated by adjusting for ever‐symptoms of gastroesophageal reflux (GER). These findings suggest in males, non‐GER factors related to abdominal obesity may be important in the development of BE. In females, there was modest association between measures of abdominal obesity and risk of BE but these were all abolished after adjusting for ever‐symptoms of GER. The power to detect differences between sexes in the risk of BE associated with abdominal obesity was limited by the number of females in the study.
Analysis of Calix[4]arenes Using Nonaqueous Capillary Electrophoresis
Authors: Su Hsiu‐Li , Lee Yi‐Ping , Hung Huan‐Yi , Lee Cheng‐Yu , Chung Wen‐Sheng , Hsieh You‐Zung 
Published: October 2012

AbstractIn nonaqueous capillary electrophoresis (NACE), an organic solvent is used in place of an aqueous medium as the background solution to improve the solubility and selectivity for hydrophobic analytes. In this study, we employed NACE with UV detection for the analysis of eight calix[4]arenes. We examined the influence of several parameters—the buffer composition, the nonaqueous solvent‘s composition and proportion, and the concentration of the electrolyte of the nonaqueous buffer—on the efficiency of the electrophoretic separation. The separation was achieved through the analyte's different effective mobility via different degrees of deprotonation on the phenolic OH groups of the calix[4]arene. This deprotonation can further affect the analyte's ability to form a complex with the metal ion. The optimized background electrolyte (BGE), comprising a mixture of N‐methylformamide/acetonitrile (30:70, v/v) and 100 mM AcOH/20 mM NH4OAc, provided rapid (<11 min) separation of the calix[4]arenes with good resolution. The relative standard deviations of the migration times for the eight analytes were all less than 1%. Within the calibration concentration range, the coefficients of determination (R2) were all greater than 0.9914. Thus, the present study demonstrated NACE can provide adequate separation for the analysis of calix[4]arenes.
Poly(2‐Oxazoline)s – Are They More Advantageous for Biomedical Applications Than Other Polymers?
Authors: Sedlacek Ondrej , Monnery Bryn D. , Filippov Sergey K. , Hoogenboom Richard , Hruby Martin 
Published: October 2012

AbstractPoly(2‐alkyl‐2‐oxazoline)s are biocompatible polymers with polypeptide‐isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water‐soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N‐(2‐hydroxypropyl)methacrylamide]. This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2‐alkyl‐2‐oxazoline)s and these commonly studied polymers in terms of their suitability for biomedical applications.
Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease
Authors: Buchman Aron S. , Nag Sukriti , Shulman Joshua M. , Lim Andrew S.P. , VanderHorst Veronique G.J.M. , Leurgans Sue E. , Schneider Julie A. , Bennett David A. 
Published: October 2012

AbstractPrevious work has showed that nigral neuron density is related to the severity of parkinsonism proximate to death in older persons without a clinical diagnosis of Parkinson's disease (PD). We tested the hypothesis that neuron density in other brain stem aminergic nuclei is also related to the severity of parkinsonism. We studied brain autopsies from 125 deceased older adults without PD enrolled in the Memory and Aging Project, a clinicopathologic investigation. Parkinsonism was assessed with a modified version of the Unified Parkinson's Disease Rating Scale (UPDRS). We measured neuron density in the substantia nigra, ventral tegmental area, locus coeruleus, and dorsal raphe, along with postmortem indices of Lewy body disease, Alzheimer's disease and cerebrovascular pathologies. Mean age at death was 88.0 years, and global parkinsonism was 14.8 (SD, 9.50). In a series of regression models that controlled for demographics and neuron density in the substantia nigra, neuron density in the locus coeruleus (estimate, −0.261; SE, 0.117; P = .028) but not in the ventral tegmental area or dorsal raphe was associated with severity of global parkinsonism proximate to death. These findings were unchanged in models that controlled for postmortem interval, whole‐brain weight, and other common neuropathologies including Alzheimer's disease and Lewy body pathology and cerebrovascular vascular pathologies. In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late‐life motor impairments. © 2012 Movement Disorder Society
Neue Prioritäten
Authors: Osterath Brigitte 
Published: October 2012

AbstractWer junge, talentierte Chemiker an sein Unternehmen binden will, schafft das heutzutage nicht mit Geld allein: Angestellte wollen ihr Privatleben nicht mehr dem Beruf unterordnen. Unternehmen reagieren auf diesen Wertewandel — einige zumindest.
Morphology study of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn)
Authors: Araya‐Sibaja Andrea M. A. , Fandaruff Cinira , Campos Carlos E. M. , Soldi Valdir , Cardoso Simone G. , Cuffini Silvia L. 
Published: October 2012

SummaryIn this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T‐500 and gelatin G‐9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X‐ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213‐221, 2013. © 2012 Wiley Periodicals, Inc.
Developing analysis and testing plug‐ins for modern IDEs: an experience report
Authors: Zhao Dan , Choudhary Shauvik Roy , Orso Alessandro 
Published: October 2012

SUMMARYPlug‐ins have become an important part of today's Integrated Development Environments (IDEs). They are useful not only for extending the IDEs’ functionality but also for customizing the IDEs for different types of projects. In this paper, we discuss some features that IDEs should provide to support the development of a specific kind of plug‐ins—plug‐ins that implement program analysis and software testing techniques. To guide the discussion, we first provide a survey of existing testing and analysis plug‐ins and, for each of these plug‐ins, discuss the details of the IDE support they use. We then present a case study based on our personal experience with building a regression‐testing plug‐in for two different IDEs. Finally, we use our findings to make a generalized discussion on the kind of capabilities a platform should provide to better support the development of program analysis and software testing plug‐ins.Copyright © 2012 John Wiley & Sons, Ltd.