bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Search for Data-Driven and Reproducible Schizophrenia Subtypes Using Resting State fMRI Data From Multiple Sites
Authors: Krohne Lærke Gebser , Hansen Ingeborg Helbech , Madsen Kristoffer H. 
Published: August 2024

Abstract
For decades, fMRI data have been used to search for biomarkers for patients with schizophrenia. Still, firm conclusions are yet to be made, which is often attributed to the high internal heterogeneity of the disorder. A promising way to disentangle the heterogeneity is to search for subgroups of patients with more homogeneous biological profiles.
We applied an unsupervised multiple co-clustering (MCC) method to identify subtypes using functional connectivity data from a multisite resting-state data set. We merged data from two publicly available databases and split the data into a discovery data set (143 patients and 143 healthy controls (HC)) and an external test data set (63 patients and 63 HC) from independent sites. On the discovery data, we investigated the stability of the clustering toward data splits and initializations. Subsequently we searched for cluster solutions, also called “views,” with a significant diagnosis association and evaluated these based on their subject and feature cluster separability, and correlation to clinical manifestations as measured with the positive and negative syndrome scale (PANSS). Finally, we validated our findings by testing the diagnosis association on the external test data.
A major finding of our study was that the stability of the clustering was highly dependent on variations in the data set, and even across initializations, we found only a moderate subject clustering stability. Nevertheless, we still discovered one view with a significant diagnosis association. This view reproducibly showed an overrepresentation of schizophrenia patients in three subject clusters, and one feature cluster showed a continuous trend, ranging from positive to negative connectivity values, when sorted according to the proportions of patients with schizophrenia. When investigating all patients, none of the feature clusters in the view were associated with severity of positive, negative, and generalized symptoms, indicating that the cluster solutions reflect other disease related mechanisms.
UAdam: Unified Adam-Type Algorithmic Framework for Nonconvex Optimization
Authors: Jiang Yiming , Liu Jinlan , Xu Dongpo , Mandic Danilo P. 
Published: August 2024

Abstract
Adam-type algorithms have become a preferred choice for optimization in the deep learning setting; however, despite their success, their convergence is still not well understood. To this end, we introduce a unified framework for Adam-type algorithms, termed UAdam. It is equipped with a general form of the second-order moment, which makes it possible to include Adam and its existing and future variants as special cases, such as NAdam, AMSGrad, AdaBound, AdaFom, and Adan. The approach is supported by a rigorous convergence analysis of UAdam in the general nonconvex stochastic setting, showing that UAdam converges to the neighborhood of stationary points with a rate of O(1/T). Furthermore, the size of the neighborhood decreases as the parameter β1 increases. Importantly, our analysis only requires the first-order momentum factor to be close enough to 1, without any restrictions on the second-order momentum factor. Theoretical results also reveal the convergence conditions of vanilla Adam, together with the selection of appropriate hyperparameters. This provides a theoretical guarantee for the analysis, applications, and further developments of the whole general class of Adam-type algorithms. Finally, several numerical experiments are provided to support our theoretical findings.
A Subtle Subversion
Authors: Soufi Youcef 
Published: August 2024

Abstract
The Arab socio-political dominance of 7th-8th century AD Muslim conquerors made its way into the classical legal discourse on kafāʾa (suitable matches in marriage). Most classical jurists considered the marriage of an Arab woman to a non-Arab man to be one of several potential sources of shame to the bride and her family. This article traces how the Persian scholars of the Šāfiʿī school in Khurasan subverted Arabo-centrism in considerations of marriage by reinterpreting the legal doctrine of kafāʾa in the late 10th-11th centuries. Khurasanian Šāfiʿīs built upon but ultimately departed from the position of their colleagues in Iraq on Arab superiority: They formulated a new understanding of lineage which excluded considerations of ethnicity. The discussion of the doctrine of kafāʾa provides an example of how non-Arabs carved a place for themselves within an Islamic legal culture that originally disadvantaged them.
The Earliest Manuscripts of Kairouan (9th-11th Centuries): New Approaches for a More Accurate Dating
Authors: Bongianino Umberto , Salah Clément 
Published: August 2024

Abstract
Based on the close examination of 32 manuscripts produced in Kairouan between the 9th and the 11th centuries, this article reassesses the content and function of their paratext and interrogates some diagnostic features of their scripts and page layout. In the first part, we demonstrate that some dated notes can refer to auditions and readings that occurred decades before the production of the manuscripts on which they appear, and therefore cannot be used as termini ante quem for dating them. In the second part, we discuss some key palaeographic parameters for a better understanding of Ifrīqī scripts, their origin, and their development, with a view to establishing a set of reliable criteria for a more accurate dating and contextualisation of this little-known material.
Trajectories of Contestation: Motivational Dynamics in Repressive Regimes
Authors: Khalil Fatma Z. , van Stekelenburg Jacquelien 
Published: August 2024

Abstract
This article examines four different trajectories of contestation individuals go through. We highlight how the five motivational dynamics function per trajectory, depending on how they interact within individuals’ psyche, their perceptions, and the surrounding political setting. We argue that through the citizens’ narratives about these political moments we can better understand how the motivational dynamics function per trajectory of contention. Our focal point is to disentangle how, under the same political conditions, individuals act differently, even though they might hold the same political stances. Repression is a focal point of analysis in the article showing how the individuals within the various trajectories react to regime’s repression differently. It is the context within which individuals within the four trajectories function that is affecting their behaviour. We investigate how the ways individual express dissent change by interacting with the regime whose repressive actions might push them to change their attitudes.
Analysis of Persian WhatsApp Messages with Reference to Age, Politeness, and the Speech Act of Request
Authors: Keshavarz Mohamad Hossein , Bahri Hossein 
Published: August 2024

Abstract
This study investigated WhatsApp messages exchanged between two generations of Iranian students and their respective lecturers in light of politeness, age, and the speech act of request. We utilised two sets of data: messages sent by current young students to two young lecturers, and those sent by former middle-aged students to two senior lecturers. Altogether, 100 WhatsApp messages were analysed (50 from each data set) focusing on salutations, body, and closing parts. The findings revealed that politeness is expressed differently across the two age groups: the younger students’ messages featured short and informal expressions and frequent use of emojis while the older group utilised elaborate messages to express politeness through the frequent use of honorifics and other politeness markers. Moreover, the younger group used WhatsApp messages towards their academic goals, such as requesting the postponement of an exam, whereas the older group messages aimed at re-establishing solidarity with their lecturers.
Feasibility of online psychosocial interventions to promote mental health recovery and well-being
Authors: Leah Peanchanan , Riewpaiboon Wachara , Sirirungruang Issavara , Visuttipun Paranee 
Published: August 2024

Background: Amid the increasing trend and huge impact of mental illness, psychosocial support (PSS) has been asserted to support individuals’ recovery. Unfortunately, about 80% of affected people cannot access care as needed. Meanwhile, digital technology has a considerable role in closing service gaps. Aims: This convergent parallel mixed methods study examines existing mental health service utilization, users’ needs for PSS, and feasibility of online PSS development. Methods: A cross-sectional interview survey was conducted using a semi-structured questionnaire at a super tertiary psychiatric hospital in Thailand from March to May 2023, with three groups of service users, having self-perceived conditions/diagnosis of schizophrenia ( n = 100), mood disorders ( n = 84), and others including alcohol and substance use, anxiety and personality disorders ( n = 52). Four focus group discussions with three user groups ( n = 16) and one multidisciplinary provider group ( n = 7) were parallelly executed. Quantitative and qualitative data were convergently analyzed using descriptive and inferential statistics, and thematic and content analysis. Results: Critical shortcomings of PSS were indicated by 75.8% of user participants. Six common types of self-determined PSS were psychoeducational program, support group, skills training, counseling, supported employment, and complimentary therapy. While psychoeducational program was feasible, support group, and counseling were possibly featured within the ‘all-at-once’ online intervention development. Conclusions: PSS development based on users’ needs can promote clinical and personal recovery outcomes, and close the service gaps. Users with mood disorders have the potential for online interventions. Peer-provider formalization, co-production approach, community engagement, digital literacy, infrastructures, and equal access factors are crucial for sustainable development.
Comparing adaptations from blood flow restriction exercise training using regulated or unregulated pressure systems: A systematic review and meta-analysis
Authors: Clarkson Matthew J. , McMahon Breanna , Warmington Stuart A. 
Published: August 2024

Objective No study has examined outcomes derived from blood flow restriction exercise training interventions using regulated compared with unregulated blood flow restriction pressure systems. Therefore, we used a systematic review and meta-analyses to compare the chronic adaptations to blood flow restriction exercise training achieved with regulated and unregulated blood flow restriction pressure systems. Data sources The electronic database search included using the tool EBSCOhost and other online database search engines. The search included Medline, SPORTDiscus, CINAHL, Embase and SpringerLink. Methods Included studies utilised chronic blood flow restriction exercise training interventions greater than two weeks duration, where blood flow restriction was applied using a regulated or unregulated blood flow restriction pressure system, and where outcome measures such as muscle strength, muscle size or physical function were measured both pre- and post-training. Studies included in the meta-analyses used an equivalent non-blood flow restriction exercise comparison group. Results Eighty-one studies were included in the systematic review. Data showed that regulated ( n = 47) and unregulated ( n = 34) blood flow restriction pressure systems yield similar training adaptations for all outcome measures post-intervention. For muscle strength and muscle size, this was reaffirmed in the included meta-analyses. Conclusion This review indicates that practitioners may achieve comparable training adaptations with blood flow restriction exercise training using either regulated or unregulated blood flow restriction pressure systems. Therefore, additional factors such as device quality, participant comfort and safety, cost and convenience are important factors to consider when deciding on appropriate equipment to use when prescribing blood flow restriction exercise training.
The Relationship between Perceived Friendship Quality and Self-Judgements in Adolescent Girls from London
Authors: Piera Pi-Sunyer Blanca , Evans Jessica , Ratcliffe Katy , Janaarthanan Kaushalya , Ahmed Saz , Kuyken Willem , Dalgleish Tim , Blakemore Sarah-Jayne 
Published: August 2024

Understanding ourselves within our peer environment is an important component of self-development during adolescence, the period of life between the onset of puberty and adulthood (between ages 10 and 24 years). We used a self-appraisal paradigm to investigate cross-sectionally the relationship between perceived friendship quality and self-judgements in adolescent girls. One hundred and sixty-three girls (9–15 years), recruited from London, United Kingdom, rated how well a set of positive and negative adjectives described themselves, or a chosen familiar other. Participants also completed a self-report friendship quality questionnaire. Higher perceived friendship quality predicted lower negative self-judgements and higher positive self-judgements. These relationships did not change across the age range tested, but there was an overall decrease in positivity effect (higher positive judgements compared to negative judgements) with age. These findings highlight the importance of investigating how different components of peer relationships are related to self-concept development in adolescence.
Is the Morriston Occupational Therapy Outcome Measure (MOTOM) an appropriate tool for reablement services?
Authors: Tooke Sophie , Warrener Julia , Leah Tamsin , Ward Joanna , Dearling Jeremy 
Published: August 2024

Introduction: The Care Act (2014) requires local authorities to provide reablement services but does not standardise how to do this, leading to different services utilising different outcome measures. This article investigates the Morriston Occupational Therapy Outcome Measure, which has been under researched in community reablement settings. Method: A questionnaire was distributed to the staff working within one local authority to seek their experience of using the Morriston Occupational Therapy Outcome Measure. The questionnaire consisted of closed and open-ended questions to gain insights into their understanding and experience of the Morriston Occupational Therapy Outcome Measure. Findings: Quantitative findings showed that staff felt they understood the Morriston Occupational Therapy Outcome Measure, and most respondents agreed that the Morriston Occupational Therapy Outcome Measure was an effective tool for reablement services. However, staff provided contradictory responses as to whether the Morriston Occupational Therapy Outcome Measure was applied consistently or that service users understand the assessment. Qualitative: Findings showed the Morriston Occupational Therapy Outcome Measure is a service user tool, service provider tool, and it provides quality assurance. However, the Morriston Occupational Therapy Outcome Measure can have restricted applicability and within this local authority, more training was needed to improve the consistency of goal-scoring. Conclusion: The Morriston Occupational Therapy Outcome Measure does have strengths within reablement services; however, to ensure it is an effective tool, this research highlights the need for a high level of training.
Optimization of activity-driven event detection for long-term ambulatory urodynamics
Authors: Zareen Farhath , Elazab Mohammed , Hanzlicek Brett , Doelman Adam , Bourbeau Dennis , Majerus Steve JA , Damaser Margot S , Karam Robert 
Published: August 2024

Lower urinary tract dysfunction (LUTD) is a debilitating condition that affects millions of individuals worldwide, greatly diminishing their quality of life. The use of wireless, catheter-free implantable devices for long-term ambulatory bladder monitoring, combined with a single-sensor system capable of detecting various bladder events, has the potential to significantly enhance the diagnosis and treatment of LUTD. However, these systems produce large amounts of bladder data that may contain physiological noise in the pressure signals caused by motion artifacts and sudden movements, such as coughing or laughing, potentially leading to false positives during bladder event classification and inaccurate diagnosis/treatment. Integration of activity recognition (AR) can improve classification accuracy, provide context regarding patient activity, and detect motion artifacts by identifying contractions that may result from patient movement. This work investigates the utility of including data from inertial measurement units (IMUs) in the classification pipeline, and considers various digital signal processing (DSP) and machine learning (ML) techniques for optimization and activity classification. In a case study, we analyze simultaneous bladder pressure and IMU data collected from an ambulating female Yucatan minipig. We identified 10 important, yet relatively inexpensive to compute signal features, with which we achieve an average 91.5% activity classification accuracy. Moreover, when classified activities are included in the bladder event analysis pipeline, we observe an improvement in classification accuracy, from 81% to 89.0%. These results suggest that certain IMU features can improve bladder event classification accuracy with low computational overhead. Clinical Relevance: This work establishes that activity recognition may be used in conjunction with single-channel bladder event detection systems to distinguish between contractions and motion artifacts for reducing the incorrect classification of bladder events. This is relevant for emerging sensors that measure intravesical pressure alone or for data analysis of bladder pressure in ambulatory subjects that contain significant abdominal pressure artifacts.
Impact of rapid-antiretroviral therapy in a cohort of treatment-naïve migrants living with HIV in a high income setting
Authors: Trevisan Sasha , Gasparro Giuseppe , Kiros Seble Tekle , Pozzi Marco , Malcontenti Costanza , Campolmi Irene , Paggi Riccardo , Cavallo Annalisa , Farese Alberto , Ducci Filippo , Meli Massimo , Pittorru Mario , Bartoloni Alessandro , Sterrantino Gaetana , Lagi Filippo 
Published: August 2024

Background We evaluated the effect of rapid ART (RA) compared to delayed ART (DA) on viral load suppression (viral load <50 cp/mL) and loss to follow-up (LTFU) in a cohort of migrants living with HIV (MLWHs) in Italy. Methods Data were retrospectively gathered from MLWHs who began care at the Infectious and Tropical Diseases Unit of the Careggi University Hospital from January 2014 to December 2022. RA was defined as antiretrovirals prescribed within 7 days of HIV diagnosis. The study ended on April 30, 2023, or upon patient LTFU. Chi-square and non-parametric tests assessed differences in categorical and continuous variables, respectively. Kaplan-Meyer survival analysis was performed to estimate the probability of loss to follow-up. Cox regression analysis was performed to evaluate factors associated with a loss to follow-up. Results 87 MLWHs were enrolled: 20 (23%) on RA and 67 (77%) on DA. In the RA group there were more PLWH with a previous AIDS event ( p < .001) however, there was no significant difference in the LTFU rates between the groups (aHR 0.6, 95%CI 0.1-3.1; p = .560; Logrank = 0.2823). Being an out-of-status MLWH was the only predictor of LTFU. By 6 months, virological suppression was achieved in 61.2% (n = 41) in DA and 70.0% in the RA group (n = 14) (Logrank p = .6747). Conclusions RA did not significantly affect LTFU rates or the achievement of viral load suppression. The study suggests that further research is needed to assess the impact of RA in high income settings.
Improving estimation efficiency of case-cohort studies with interval-censored failure time data
Authors: Zhou Qingning , Wong Kin Yau 
Published: August 2024

The case-cohort design is a commonly used cost-effective sampling strategy for large cohort studies, where some covariates are expensive to measure or obtain. In this paper, we consider regression analysis under a case-cohort study with interval-censored failure time data, where the failure time is only known to fall within an interval instead of being exactly observed. A common approach to analyzing data from a case-cohort study is the inverse probability weighting approach, where only subjects in the case-cohort sample are used in estimation, and the subjects are weighted based on the probability of inclusion into the case-cohort sample. This approach, though consistent, is generally inefficient as it does not incorporate information outside the case-cohort sample. To improve efficiency, we first develop a sieve maximum weighted likelihood estimator under the Cox model based on the case-cohort sample and then propose a procedure to update this estimator by using information in the full cohort. We show that the update estimator is consistent, asymptotically normal, and at least as efficient as the original estimator. The proposed method can flexibly incorporate auxiliary variables to improve estimation efficiency. A weighted bootstrap procedure is employed for variance estimation. Simulation results indicate that the proposed method works well in practical situations. An application to a Phase 3 HIV vaccine efficacy trial is provided for illustration.
Examining breast cancer screening recommendations in Canada: The projected resource impact of screening among women aged 40–49
Authors: Basmadjian Robert B , Ruan Yibing , Hutchinson John M , Warkentin Matthew T , Alagoz Oguzhan , Coldman Andrew , Brenner Darren R 
Published: August 2024

Objective To quantify the resource use of revising breast cancer screening guidelines to include average-risk women aged 40–49 years across Canada from 2024 to 2043 using a validated microsimulation model. Setting OncoSim-Breast microsimulation platform was used to simulate the entire Canadian population in 2015–2051. Methods We compared resource use between current screening guidelines (biennial screening ages 50–74) and alternate screening scenarios, which included annual and biennial screening for ages 40–49 and ages 45–49, followed by biennial screening ages 50–74. We estimated absolute and relative differences in number of screens, abnormal screening recalls without cancer, total and negative biopsies, screen-detected cancers, stage of diagnosis, and breast cancer deaths averted. Results Compared with current guidelines in Canada, the most intensive screening scenario (annual screening ages 40–49) would result in 13.3% increases in the number of screens and abnormal screening recalls without cancer whereas the least intensive scenario (biennial screening ages 45–49) would result in a 3.4% increase in number of screens and 3.8% increase in number of abnormal screening recalls without cancer. More intensive screening would be associated with fewer stage II, III, and IV diagnoses, and more breast cancer deaths averted. Conclusions Revising breast cancer screening in Canada to include average-risk women aged 40–49 would detect cancers earlier leading to fewer breast cancer deaths. To realize this potential clinical benefit, a considerable increase in screening resources would be required in terms of number of screens and screen follow-ups. Further economic analyses are required to fully understand cost and budget implications.