bluuebunny/crossref_metadata_2025_split huggingface dataset:
Place of death in the population dying from diseases indicative of palliative care need: a cross-national population-level study in 14 countries
Authors: Pivodic Lara , Pardon Koen , Morin Lucas , Addington-Hall Julia , Miccinesi Guido , Cardenas-Turanzas Marylou , Onwuteaka-Philipsen Bregje , Naylor Wayne , Ruiz Ramos Miguel , Van den Block Lieve , Wilson Donna M , Loucka Martin , Csikos Agnes , Rhee Yong Joo , Teno Joan , Deliens Luc , Houttekier Dirk , Cohen Joachim 
Published: July 2015

BackgroundStudying where people die across countries can serve as an evidence base for health policy on end-of-life care. This study describes the place of death of people who died from diseases indicative of palliative care need in 14 countries, the association of place of death with cause of death, sociodemographic and healthcare availability characteristics in each country and the extent to which these characteristics explain country differences in the place of death.MethodsDeath certificate data for all deaths in 2008 (age ≥1 year) in Belgium, Canada, the Czech Republic, England, France, Hungary, Italy, Mexico, the Netherlands, New Zealand, South Korea, Spain (Andalusia), the USA and Wales caused by cancer, heart/renal/liver failure, chronic obstructive pulmonary disease, diseases of the nervous system or HIV/AIDS were linked with national or regional healthcare statistics (N=2 220 997).Results13% (Canada) to 53% (Mexico) of people died at home and 25% (the Netherlands) to 85% (South Korea) died in hospital. The strength and direction of associations between home death and cause of death, sociodemographic and healthcare availability factors differed between countries. Differences between countries in home versus hospital death were only partly explained by differences in these factors.ConclusionsThe large differences between countries in and beyond Europe in the place of death of people in potential need of palliative care are not entirely attributable to sociodemographic characteristics, cause of death or availability of healthcare resources, which suggests that countries’ palliative and end-of-life care policies may influence where people die.
Simulating the area covered by lava flows using the DOWNFLOW code
Authors: Tarquini Simone , Favalli Massimiliano 
Published: July 2015

Abstract

DOWNFLOW is a probabilistic code for the simulation of the area covered by lava flows. This code has been used extensively for several basaltic volcanoes in the last decade, and a review of some applications is presented. DOWNFLOW is based on the simple principle that a lava flow tends to follow the steepest descent path downhill from the vent. DOWNFLOW computes the area possibly inundated by lava flows by deriving a number,
N
, of steepest descent paths, each path being calculated over a randomly perturbed topography. The perturbation is applied at each point of the topography, and ranges within the interval ±Δ
h
.
N
and Δ
h
are the two basic parameters of the code. The expected flow length is constrained by statistical weighting based on the past activity of the volcano. The strength of the code is that: (i) only limited volcanological knowledge is necessary to apply the code at a given volcano; (ii) there are only two (easily tunable) input parameters; and (iii) computational requirements are very low. However, DOWNFLOW does not provide the progression of the lava emplacement over time. The use of DOWNFLOW is ideal when a large number of simulations are necessary: for example, to compile maps for hazard and risk-assessment purposes.
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros 
Published: July 2015

Abstract
Acquired resistance to therapy is perhaps the greatest challenge to effective clinical management of cancer. With several inhibitors of the mitotic checkpoint kinase MPS1 in preclinical development, we sought to investigate how resistance against these inhibitors may arise so that mitigation or bypass strategies could be addressed as early as possible. Toward this end, we modeled acquired resistance to the MPS1 inhibitors AZ3146, NMS-P715, and CCT251455, identifying five point mutations in the kinase domain of MPS1 that confer resistance against multiple inhibitors. Structural studies showed how the MPS1 mutants conferred resistance by causing steric hindrance to inhibitor binding. Notably, we show that these mutations occur in nontreated cancer cell lines and primary tumor specimens, and that they also preexist in normal lymphoblast and breast tissues. In a parallel piece of work, we also show that the EGFR p.T790M mutation, the most common mutation conferring resistance to the EGFR inhibitor gefitinib, also preexists in cancer cells and normal tissue. Our results therefore suggest that mutations conferring resistance to targeted therapy occur naturally in normal and malignant cells and these mutations do not arise as a result of the increased mutagenic plasticity of cancer cells. Cancer Res; 75(16); 3340–54. ©2015 AACR.
Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-κB Pathway
Authors: Liao Dan , Zhong Li , Duan Tingmei , Zhang Ru-Hua , Wang Xin , Wang Gang , Hu Kaishun , Lv Xiaobin , Kang Tiebang 
Published: July 2015

Abstract
Purpose: Aspirin has recently been reported to reduce both the incidence and the risk of metastasis in colon cancer. However, there is no evidence at the cellular levels or in the animal models for such an effect of aspirin on cancer metastasis.
Experimental Design: MTT assay, colony formation assay, and apoptosis assay were employed to analyze the effects of aspirin on the osteosarcoma cell viability in vitro. The NF-κB activity was measured by the NF-κB p65 luciferase reporter. Western blotting was used to analyze the proteins in cells. The migration and invasion abilities of osteosarcoma cells in vitro were measured by the Transwell assay. Xenograft-bearing mice were used to assess the roles of aspirin in both tumor growth and metastasis of osteosarcoma in vivo (n = 5–8 mice/group). An unpaired Student t test or ANOVA with the Bonferroni post hoc test were used for the statistical comparisons.
Results: Aspirin reduced cell viability in a dose- and time-dependent manner in osteosarcoma cell lines, and aspirin synergistically sensitized osteosarcoma cells to cisplatin (DDP) in vitro and in vivo (P &lt; 0.001). Moreover, aspirin markedly repressed the migration and invasion of osteosarcoma cells in vitro (P &lt; 0.001), and dramatically diminished the occurrence of osteosarcoma xenograft metastases to the lungs in vivo (P &lt; 0.001). Mechanistically, aspirin diminishes osteosarcoma migration, invasion, and metastasis through the NF-κB pathway.
Conclusions: Aspirin suppresses both the growth and metastasis of osteosarcoma through the NF-κB pathway at the cellular level and in the animal models. Clin Cancer Res; 21(23); 5349–59. ©2015 AACR.
Role of mTOR1 and mTOR2 complexes in MEG-01 cell physiology
Authors: López Esther , Berna-Erro Alejandro , López Javier J. , Granados María P. , Bermejo Nuria , Brull José M. , Salido Ginés M. , Rosado Juan A. , Redondo Pedro C. 
Published: July 2015

SummaryThe function of the mammalian target of rapamycin (mTOR) is upregulated in response to cell stimulation with growing and differentiating factors. Active mTOR controls cell proliferation, differentiation and death. Since mTOR associates with different proteins to form two functional macromolecular complexes, we aimed to investigate the role of the mTORI and mTOR2 complexes in MEG-01 cell physiology in response to thrombopoietin (TPO). By using mTOR antagonists and overexpressing FKBP38, we have explored the role of both mTOR complexes in proliferation, apoptosis, maturation-like mechanisms, endoplasmic reticulum-stress and the intracellular location of both active mTOR complexes during MEG-01 cell stimulation with TPO. The results demonstrate that mTOR1 and mTOR2 complexes play different roles in the physiology of MEG-01 cells and in the maturation-like mechanisms; hence, these findings might help to understand the mechanism underlying generation of platelets.
All-cause mortality and use of antithrombotics within 90 days of discharge in acutely ill medical patients
Authors: Mahan Charles , Fields Larry , Mills Roger , Stephenson Judith , Fu An-Chen , Fisher Maxine , Spyropoulos Alex 
Published: July 2015

SummaryConflicting evidence exists regarding predictors of and antithrombotic benefit on mortality in hospitalised acutely-ill medical patients. We compared mortality risk within 90 days post-discharge among medically ill patients who did and did not receive antithrombotics. This retrospective claims analysis included patients40 years with nonsurgical hospitalisation2 days between 2005 and 2009 using the HealthCore Integrated Research Database. Antithrombotic use (i.e. anticoagulants and antiplatelets) post-discharge was captured from pharmacy claims. All-cause mortality was determined from Social Security Death Index; cause of death was identified from National Death Index database. Kaplan-Meier survival curves were generated and hazard ratios (HR) for mortality risk were estimated using Cox proportional hazards models. Patients prescribed anticoagulants or antiplatelets post-discharge had lower risk of short-term mortality. For the anticoagulant model, the most significant predictors of mortality were malignant/benign neoplasms (hazard ratio [HR] 1.6, 95 % confidence interval [CI] 1.5–1.7), liver disease (HR 1.6, 95 % CI 1.5–1.7), anticoagulant omission (HR 1.6, 95 % CI 1.4–1.8), gastrointestinal or respiratory tract intubations (HR 1.5, 95 % CI 1.3–1.7), and blood dyscrasias (HR 1.4, 95 % CI 1.4–1.5). For the antiplatelet model, the most significant predictors of mortality were antiplatelet omission (HR 3.7, 95 % CI 3.3–4.1), liver disease (HR 1.6, 95 % CI 1.4–1.7), malignant/benign neoplasms (HR 1.6, 95 % CI 1.5–1.6), gastrointestinal or respiratory tract intubations (HR 1.5, 95 % CI 1.3–1.7), and blood dyscrasias (HR 1.4, 95 % CI 1.4–1.5). These mortality risk factors may guide future studies assessing potential benefits of antithrombotics in specific subsets of patients.
Management of adjunctive antithrombotic therapy in STEMI patients treated with fibrinolysis undergoing rescue or delayed PCI
Authors: Angiolillo Dominick J. , Capodanno Davide 
Published: July 2015

SummaryAlthough primary percutaneous coronary intervention (PCI) is the recommended method of reperfusion in patients presenting with ST-segment elevation myocardial infarction (STEMI), fibrinolysis remains a beneficial alternative in patients who cannot be reperfused timely with primary PCI, and is still the preferred revascularisation strategy in many parts of the world where PCI facilities are unavailable. Because fibrinolysis is known to activate platelets and promote thrombin activity, concomitant administration of antiplatelet and anticoagulant therapies is needed to lower the risk for re-occlusion and to support mechanical interventions in patients undergoing rescue or delayed PCI. However, the addition of oral antiplatelet and parenteral anticoagulant drugs on top of fibrinolysis may come at the price of an increased risk of bleeding. The current availability of several antiplatelet and anticoagulant therapies often leads to questions about the optimal selection in STEMI patients treated with fibrinolytics. This article appraises current evidences for the management of adjunctive antiplatelet and anticoagulant therapies in patients with STEMI undergoing fibrinolysis followed by rescue or delayed PCI.
Antithrombotic drugs and subarachnoid haemorrhage risk
Authors: Pottegård Anton , Rodríguez Luis Alberto García , Poulsen Frantz Rom , Hallas Jesper , Gaist David 
Published: July 2015

SummaryThe study objective was to investigate the relationship between use of antithrombotic drugs and subarachnoid haemorrhage (SAH). We identified patients discharged from Danish neurosurgery units with a first-ever SAH diagnosis in 2000 to 2012 (n=5,834). For each case, we selected 40 age-, sex- and period-matched population controls. Conditional logistic regression models were used to estimate odds ratios (aOR), adjusted for comorbidity, education level, and income. Low-dose aspirin (ASA) use for < 1 month was associated with an increased risk of SAH (aOR 1.75, 95% confidence interval [CI] 1.28–2.40). This aOR decreased to 1.26 (95%CI: 0.98–1.63) with 2–3 months of ASA use, and approached unity with use for more than three months (1.11, 95%CI 0.97–1.27). Analyses with first-time users confirmed this pattern, which was also observed for clopidogrel. ASA treatment for three or more years was associated with an aOR of SAH of 1.13 (95%CI: 0.86–1.49). Short-term use (< 1 month) of vitamin K-antagonists (VKA) yielded an aOR of 1.85 (95%CI 0.97–3.51) which dropped after 3+ years to 1.24, 95%CI: 0.86–1.77. The risk of SAH was higher in subjects in dual antithrombotic treatment (aOR 2.08, 95%CI: 1.26–3.44), and in triple antithrombotic treatment (aOR 5.74, 95%CI: 1.76–18.77). In conclusion, use of aspirin,clopidogrel and VKA were only associated with an increased risk of SAH in the first three months after starting treatment. Long-term aspirin use carried no reduced SAH risk. Results should be interpreted cautiously due to their observational nature.
Reduced peak, but no diurnal variation, in thrombin generation upon melatonin supplementation in tetraplegia
Authors: Dahm Anders , Skretting Grethe , Mowinckel Marie-Christine , Stranda Annicke , Østerud Bjarne , Sandset Per Morten , Kostovski Emil , Iversen Per Ole 
Published: July 2015

SummaryTetraplegic patients have increased risk of venous thrombosis despite anti-thrombotic prophylaxis. Moreover, they have blunted plasma variations in melatonin and altered diurnal variation of several haemostatic markers, compared with able-bodied. However, whether healthy individuals and tetraplegic patients, with or without melatonin, display abnormalities in thrombin generation during a 24-hour (h) cycle, is unknown. We therefore used the Calibrated Automated Thrombogram (CAT) assay to examine diurnal variations and the possible role of melatonin in thrombin generation. Six men with long-standing complete tetraplegia were included in a randomised placebo-controlled cross-over study with melatonin supplementation (2 mg, 4 consecutive nights), whereas six healthy, able-bodied men served as controls. Ten plasma samples were collected frequently during a 24-h awake/sleep cycle. No significant diurnal variation of any of the measured CAT indices was detected in the three study groups. Whereas endogenous thrombin potential (ETP) was independent (p > 0.05) of whether the tetraplegic men received melatonin or placebo, melatonin decreased (p = 0.005) peak values in tetraplegia compared with those given placebo. Able-bodied men had lower (p = 0.019) ETP and Lag-Time (p = 0.018) compared with tetraplegics receiving placebo. Neither the Time-to-Peak nor the Start-Tail was affected (p > 0.05) by melatonin in tetraplegia. In conclusion, indices of thrombin generation are not subjected to diurnal variation in healthy able-bodied or tetraplegia, but peak thrombin generation is reduced in tetraplegic men receiving oral melatonin.
Regime Transitions of Cross-Equatorial Hadley Circulations with Zonally Asymmetric Thermal Forcings
Authors: Zhai Jun , Boos William 
Published: July 2015

Abstract
Observed nonlinearities in the seasonal evolution of monsoons have been previously explained using theories for Hadley circulations driven by zonally symmetric thermal forcings, even though monsoonal forcings deviate strongly from the assumption of zonal symmetry. Here, an idealized model of a dry, three-dimensional atmosphere is used to compare the response to zonally symmetric and asymmetric off-equatorial thermal forcings. For symmetric forcings, the zonal-mean, cross-equatorial mass flux increases more rapidly with the amplitude of the forcing once the forcing becomes strong enough to reduce the upper-tropospheric absolute vorticity to near zero, consistent with previous studies of the transition to angular momentum–conserving flow. For zonally asymmetric forcings, the zonal-mean cross-equatorial flow exhibits a similar dependence on forcing strength and a similar reduction of the zonal-mean upper-level vorticity, but asymmetric forcings also produce strong zonal overturnings with subsidence west of the heating, as in the well-known linear response to off-equatorial heatings. The mass flux in these zonal overturnings increases linearly with forcing strength until its rate of increase tapers off for the strongest forcings; the total upward mass flux (i.e., the zonal-mean plus zonally asymmetric components) increases linearly with the strength of zonally asymmetric forcings and exhibits no abrupt or nonlinear dependence on forcing amplitude. These results indicate the importance of considering the zonally asymmetric part of the divergent response to off-equatorial forcings and suggest that theories based on zonally symmetric forcings need further examination before they can be assumed to describe observed monsoons.
A Momentum Budget Analysis of Westerly Wind Events Associated with the Madden–Julian Oscillation during DYNAMO
Authors: Oh Ji-Hyun , Jiang Xianan , Waliser Duane E. , Moncrieff Mitchell W. , Johnson Richard H. , Ciesielski Paul 
Published: July 2015

Abstract
The Dynamics of the Madden–Julian Oscillation (DYNAMO) field campaign was conducted over the Indian Ocean (IO) from October 2011 to February 2012 to investigate the initiation of the Madden–Julian oscillation (MJO). Three MJOs accompanying westerly wind events (WWEs) occurred in late October, late November, and late December 2011. Momentum budget analysis is conducted to understand the contributions of the dynamical processes involved in the wind evolution associated with the MJO over the IO during DYNAMO using European Centre for Medium-Range Weather Forecasts analysis. This analysis shows that westerly acceleration at lower levels associated with the MJO active phase generally appears to be maintained by the pressure gradient force (PGF), which could be partly canceled by meridional advection of the zonal wind. Westerly acceleration in the midtroposphere tends to be mostly attributable to vertical advection. The results herein imply that there is no simple linear dynamic model that can capture the WWEs associated with the MJO and that nonlinear processes have to be considered.
In addition, the MJO in November (MJO2), accompanied by two WWEs (WWE1 and WWE2) spaced a few days apart, is diagnosed. Unlike other WWEs during DYNAMO, horizontal advection is more responsible for the westerly acceleration in the lower troposphere for WWE2 than the PGF. Interactions between the MJO2 envelope and convectively coupled waves (CCWs) are analyzed to illuminate the dynamical contribution of these synoptic-scale equatorial waves to the WWEs. The authors suggest that different developing processes among WWEs can be attributed to different types of CCWs.
Phase-Specific Characteristics of Wintertime Clouds across a Midlatitude Mountain Range
Authors: Dorsi S. W. , Shupe M. D. , Persson P. O. G. , Kingsmill D. E. , Avallone L. M. 
Published: July 2015

Abstract
Observations from a series of frontal and postfrontal storms during the Colorado Airborne Multiphase Cloud Study (CAMPS) are combined to show transitions in cloud dynamics and microphysical statistics over a mountain range. During 10 flights in 2010 and 2011, along-wind, across-ridge transects over the Colorado Park Range are performed to statistically characterize air motion and microphysical conditions and their variability. Composite transect statistics show median vertical winds to be mostly upward windward of the ridge axis, and that cloud water concentration (CWC) and ice-particle number concentration are greatest near the ridge. Mixed-phase clouds were found throughout the study area, but increase in frequency by 70% relative to other cloud types in the vicinity of the range. Compared to ice-only clouds, mixed-phase clouds are associated with greater near-ridge increases in CWC and preferentially occur in regions with greater vertical wind variability or updrafts. Strong leeside reductions in CWC, the abundance of mixed-phase clouds, and number concentration of ice particles reflect the dominance of precipitation and particle mass loss processes, rather than cloud growth processes, downwind from the topographic barrier. On days in which the air column stability does not support lee subsidence, this spatial configuration is markedly different, with both ice- and liquid-water-bearing clouds appearing near the ridgeline and extending downwind. A case study from 9 January 2011 highlights mixed-phase regions in trapped lee waves, and in a near-ridgetop layer with evidence of low-altitude ice particle growth.
Determining Regional Weather Patterns from a Historical Diary
Authors: Bernhardt Jase 
Published: July 2015

Abstract
Prior to the twentieth century, there was a dearth of official local weather and climate observations for much of the United States outside of major cities. Useful information can be gleaned, however, from primary accounts, such as historical diaries kept by farmers and others whose interests were tied to the land. Herman Smith, a farmer in west-central New York State, kept a detailed record of daily life, including weather characteristics such as temperature, precipitation, and wind, for his farm near Covert. Two full years of his diary, 1884 and 1886, were recently published and selected for study. Although typically not numeric data, the lexicon used in the diary to describe relative heat and cold allow Smith’s observations to be analyzed semiquantitatively in order to determine the weather experienced that year including factors affecting the growing season, as well as significant weather and climatic events. The analysis demonstrates that for Covert—located in an area of topographic variability and proximal to the Finger Lakes—microclimatic effects occasionally dominated over the synoptic circulation. This finding was further reinforced by comparison of Smith’s 1886 records with those of a nearby farmer. Meanwhile, Smith’s accounts also establish an inextricable link between his agricultural practices and the weather and climate patterns he observed. These findings underscore the value of acquiring climatic data from nonconventional sources for places and times when reliable data may be nonexistent in order to better understand how climate, and its impacts on the environment, have varied over time, across multiple scales.