bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sales mode selection considering the consumer reference quality effect
Authors: Qiu Ruozhen , Yu Yue , Sun Minghe 
Published: August 2024

AbstractThis work investigates a two‐tier supply chain in which a supplier adjusts product quality and prices and distributes the products through a retailer or directly to consumers with the reference quality (RQ) effect. The supplier can choose from three, that is, traditional sales (TS), dual‐channel (DC), and online‐to‐offline (O2O), sales modes. In the O2O sales mode, the retailer is allowed to open an online channel. The market demands are determined by the consumer utility consisting of two parts, a part depending on the consumer RQ effect and the other depending on the retail price and product quality. The profit maximization, that is, the Stackelberg game, models involving the consumer RQ effect are developed using prospect theory, wherein the supplier has the first mover advantage. The analytical optimal solutions are obtained through backward induction. The optimal quality and pricing decisions and the optimal profits of the supply chain members are compared among the three sales modes. A practical application is analyzed to verify the theoretical results of the proposed models. The results show that the consumer RQ effect benefits the two supply chain members under certain conditions. The optimal quality and pricing decisions are significantly affected by the consumer RQ effect except those of the supplier under the O2O sales mode. When consumers have the RQ effect, the DC sales mode is the best choice for the supplier, is a win–win mode for the two supply chain members under certain conditions, and benefits the consumers the most among the three sales modes.
Does digital transformation promote supply chain efficiency? Evidence from China
Authors: Liu Yuanyuan , Chi Guodong 
Published: August 2024

AbstractWith the deepening of industrial division of labor, supply chain efficiency has become a critical driver of companies' core competitiveness. Using a sample of Chinese A‐share listed companies from 2007 to 2023, this paper empirically investigates the impact of digital transformation on supply chain efficiency. We find that firms with a higher degree of digital transformation are associated with higher supply chain efficiency. Mechanism tests show that digital transformation facilitates supply chain efficiency via lower customer demand uncertainty as well as raw material disruption risk. The positive effect of digital transformation is more pronounced for non‐state‐owned enterprises and for firms with less stable customers and more geographically dispersed suppliers. Moreover, there is much degree prompt in supply chain efficiency for firms located in a better digital environment. This paper sheds light on how digital transformation influences supply chain efficiency and provides significant insights for firms to improve supply chain efficiency.
Aqueous Extract of Wolfberry Alleviates Aging‐Related Skeletal Muscle Dysfunction by Modulating PRRs Signaling Pathways and Enhancing DNA Repair
Authors: Zheng Qingwei , Chen Xiaofang , AL‐Ansi Waleed , Fan Mingcong , Qian Haifeng , Wang Li , Li Yan 
Published: August 2024

AbstractAging can lead to a series of degenerative changes in skeletal muscle, which would negatively impact physical activity and the quality of life of the elderly. Wolfberry contains numerous bioactive substances. It's vital to further explore the mechanisms underlying its healthy effects on skeletal muscle function during aging progress. This study discusses the benefits and mechanisms of aqueous extract of wolfberry (AEW) to protect skeletal muscle from aging‐related persistent DNA damage based on its anti‐inflammatory activity. It is found that AEW improves muscle mass, strength, and endurance, modulates the expression of Atrogin‐1, MyH, and MuRF‐1, and decreases oxidative stress and inflammation levels in aging mice, which is consistent with the in vitro results. Mechanistically, AEW inhibits the pattern recognition receptors (PRRs) pathway induced by inflammatory gene activation, suggesting its potential in response to DNA damage. AEW is also observed to mitigate chromatin decompaction. Network pharmacology is conducted to analyze the potential targets of AEW in promoting DNA repair. In conclusion, the study shows the anti‐aging effects of AEW on skeletal muscle by promoting DNA repair and reducing the transcriptional activity of inflammatory factors. AEW intake may become a potential strategy for strengthening skeletal muscle function in the elderly.
Quality and Readability of Noise‐Induced Hearing Loss Prevention‐Related Websites
Authors: Howard Tyler , Willgruber Abbigayle , Kinealy Brian , Adkins David , Jones Raleigh , Bush Matthew 
Published: August 2024

AbstractObjectiveThis cross‐sectional website analysis aimed to determine the readability and quality of English and Spanish websites pertaining to the prevention of noise‐induced hearing loss.Study DesignCross‐sectional website analysis.SettingVarious online search engines.MethodsWe queried four popular search engines using the term “noise‐induced hearing loss prevention” to reveal the top 50 English and top 50 Spanish websites for data collection. Websites meeting inclusion criteria were stratified based on the presence of a Health on the Net Code certificate (independent assessment of honesty, reliability, and quality). Websites were then independently reviewed by experts using the DISCERN criteria in order to assess information quality. Readability was calculated using the Flesch reading ease score for English and the Fernandez‐Huerta formula for Spanish websites.ResultsThirty‐six English websites and 32 Spanish websites met the inclusion criteria. English websites had significantly lower readability (average = 56.34, SD = 11.17) compared to Spanish websites (average = 61.88, SD = 5.33) (P < .05). Spanish websites (average = 37, SD = 8.47) were also of significantly higher quality than English websites (average = 25.13, SD = 10.11).ConclusionThis study emphasizes the importance of providing quality and readable materials to patients seeking information about noise‐induced hearing loss prevention. All of the English and Spanish websites reviewed were written at a level higher than the American Medical Association‐recommended sixth‐grade reading level. The study also highlights the need for evidence‐based information online provided by experts in our field.
Validation of a Major and Clinically Relevant Nonmajor Bleeding Phenotyping Algorithm on Electronic Health Records
Authors: Yap Aaron Jun Yi , Teo Desmond Chun Hwee , Ang Pei San , Yap Eng Soo , Tan Siew Har , Loke Celine Wei Ping , Dorajoo Sreemanee Raaj 
Published: August 2024

ABSTRACTPurposeBleeding is an important health outcome of interest in epidemiological studies. We aimed to develop and validate rule‐based algorithms to identify (1) major bleeding and (2) all clinically relevant bleeding (CRB) (composite of major and all clinically relevant nonmajor bleeding) within real‐world electronic healthcare data.MethodsWe took a random sample (n = 1630) of inpatient admissions to Singapore public healthcare institutions in 2019 and 2020, stratifying by hospital and year. We included patients of all age groups, sex, and ethnicities. Presence of major bleeding and CRB were ascertained by two annotators through chart review. A total of 630 and 1000 records were used for algorithm development and validation, respectively. We formulated two algorithms: sensitivity‐ and positive predictive value (PPV)‐optimized algorithms. A combination of hemoglobin test patterns and diagnosis codes were used in the final algorithms.ResultsDuring validation, diagnosis codes alone yielded low sensitivities for major bleeding (0.16) and CRB (0.24), although specificities and PPV were high (>0.97). For major bleeding, the sensitivity‐optimized algorithm had much higher sensitivity and negative predictive values (NPVs) (sensitivity = 0.94, NPV = 1.00), however false positive rates were also relatively high (specificity = 0.90, PPV = 0.34). PPV‐optimized algorithm had improved specificity and PPV (specificity = 0.96, PPV = 0.52), with little reduction in sensitivity and NPV (sensitivity = 0.88, NPV = 0.99). For CRB events, our algorithms had lower sensitivities (0.50–0.56).ConclusionsThe use of diagnosis codes alone misses many genuine major bleeding events. We have developed major bleeding algorithms with high sensitivities, which can ascertain events within populations of interest.
Adverse Menstrual Events Reported After and Before (or Without) COVID‐19 Vaccination: A Systematic Review and Meta‐Analysis of Comparative Observational Studies
Authors: Peinemann Frank , Oberle Doris , Drechsel‐Bäuerle Ursula , Keller‐Stanislawski Brigitte 
Published: August 2024

ABSTRACTBackgroundReports of adverse menstrual events emerged during the COVID‐19 vaccination campaign in multiple countries. This raised the question whether these reports were caused by the vaccines. The aim of this systematic review was to evaluate comparative studies on this topic (registered at PROSPERO [CRD42022324973]).MethodsWe included observational studies such as cohort studies and surveys comparing the response to self‐reported questionnaires between post‐ versus pre‐vaccination data. PubMed and Cochrane Library searches were conducted on 1 September 2023. The primary outcome was the incidence of any prespecified adverse menstrual event, and the outcome measure was the risk ratio. The meta‐analysis was conducted by using the Mantel–Haenszel method and the random effects model. We summarized the results on risk factors as well as key findings of the studies included.ResultsWe retrieved 161 references from electronic databases and additional sources such as references lists. Of those, we considered 21 comparative observational studies. The meta‐analysis of any adverse menstrual adverse event reported in 12 studies resulted in a pooled estimate (risk ratio 1.13; 95% CI, 0.96–1.31) that did not favor any group. The analysis was constrained by considerable clinical and statistical heterogeneity. Risk factors for self‐reported menstrual changes included a history of COVID‐19 infection, the concern about COVID‐19 vaccines, smoking, previous cycle irregularities, depression, and stress, and other issues.ConclusionsThe risk ratio did not favor any group and heterogeneity was prevalent among the studies. Most studies suggested that the reported changes were temporary, minor, and nonserious.
Enhancement in the impact and torsional properties of 3D‐printed biocompatible poly(lactic acid) locking bone plates: sustainable integration into healthcare applications
Authors: Sharma Shrutika , Gupta Vishal , Mudgal Deepa 
Published: August 2024

AbstractLocking bone plates (LoBPs) are utilized in orthopedic surgeries for supporting segments of distal ulna fracture. Primarily constructed from metallic biomaterials that are much stiffer than natural bone, LoBPs result in stress shielding and are prone to corrosion. As a result, there has been a growing preference for biocompatible and biodegradable polymeric biomaterials for creating patient‐specific implants using 3D printing. Among various biomaterials, poly(lactic acid) (PLA) stands out due to its favorable biocompatibility and biodegradability. The layer‐by‐layer deposition in this process raises issues about layer bonding, reducing the mechanical strength of the implants. Nevertheless, adjusting process parameters can enhance the mechanical strength of the produced parts. The current study aimed to examine the influence of printing parameters on the impact strength and torque withstanding ability of biocompatible and biodegradable PLA‐based LoBPs using response surface methodology. The experimental results reveal that an increase in infill density and wall thickness minimize porosity and enhance inter‐layer bonding, imparting high impact and torsional resistance against forces. Conversely, an increase in layer height and printing speed induces porosity, leading to early fracture of layers under sudden impact and torsional forces. The fractured surface morphology of LoBPs after impact and torsional testing was analyzed using SEM. The MATLAB‐based optimization yielded maximum impact strength and torque values of 27.175 kJ m−2 and 3644 N mm, respectively. The study underscores the potential of biocompatible and biodegradable PLA‐based 3D‐printed LoBPs for sustainable integration into biomedical applications. © 2024 Society of Chemical Industry.
Deep phosphotyrosine characterisation of primary murine T cells using broad spectrum optimisation of selective triggering
Authors: Callahan Aurora , Chua Xien Yu , Griffith Alijah A. , Hildebrandt Tobias , Fu Guoping , Hu Mengzhou , Wen Renren , Salomon Arthur R. 
Published: August 2024

AbstractSequencing the tyrosine phosphoproteome using MS‐based proteomics is challenging due to the low abundance of tyrosine phosphorylation in cells, a challenge compounded in scarce samples like primary cells or clinical samples. The broad‐spectrum optimisation of selective triggering (BOOST) method was recently developed to increase phosphotyrosine sequencing in low protein input samples by leveraging tandem mass tags (TMT), phosphotyrosine enrichment, and a phosphotyrosine‐loaded carrier channel. Here, we demonstrate the viability of BOOST in T cell receptor (TCR)‐stimulated primary murine T cells by benchmarking the accuracy and precision of the BOOST method and discerning significant alterations in the phosphoproteome associated with receptor stimulation. Using 1 mg of protein input (about 20 million cells) and BOOST, we identify and precisely quantify more than 2000 unique pY sites compared to about 300 unique pY sites in non‐BOOST control samples. We show that although replicate variation increases when using the BOOST method, BOOST does not jeopardise quantitative precision or the ability to determine statistical significance for peptides measured in triplicate. Many pY previously uncharacterised sites on important T cell signalling proteins are quantified using BOOST, and we identify new TCR responsive pY sites observable only with BOOST. Finally, we determine that the phase‐spectrum deconvolution method on Orbitrap instruments can impair pY quantitation in BOOST experiments.
Preparation, characterization and thermal properties of nitrographene coated aluminum powder
Authors: Ding Xiaoyong , Fang Yitong , Emu Ayimu , Cao Yidan , Liu Qiangqiang , Chen Baili , Liu Yingle , Tan Yingxin 
Published: August 2024

AbstractAluminum powder is commonly used as a metal fuel additive in composite solid propellants. However, its tendency to agglomerate during combustion can lead to two‐phase flow losses, negatively impacting its energy performance. To address this issue and enhance the combustion performance of aluminum powder, nitrated graphene oxide (NGO) was developed to improve aluminum dispersion and optimize its energy characteristics. Various analytical techniques were employed to examine its properties, including Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), elemental analysis (EA), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). Al/NGO composite was prepared using a solution‐assisted method in N, N‐dimethylformamide (DMF) and characterized by SEM, XPS and X‐ray diffraction (XRD). The ignition characteristics and heat of combustion of Al/NGO powder were measured using a laser igniter and an oxygen bomb calorimetry. The appropriate mass ratios of NGO coating had positive effects on the ignition and combustion of Al. Specially, 4 % NGO coating reduced Al ignition energy by 46.5 % and increased the Al combustion efficiency by 22.0 %. Moreover, the catalytic effect of Al/NGO on the thermal decomposition of ammonium perchlorate (AP) was investigated using differential thermal analysis (DTA). Results showed that two‐stage pyrolysis paths of AP tended to merge into a single pyrolysis process when Al/NGO4 % was added. The most favorable catalytic effect on AP′s thermal decomposition process was produced with the addition of 10 % Al/NGO4 %, reducing the activation energy by Kissinger equation for high‐temperature decomposition to 107.7 kJ mol−1. These findings may provide valuable insight for enhancing the performance of aluminum powder in energetic materials through NGO modification.
Fabrication and performance characterization of NTO/HMX spherical composite explosives with improved safety performance.
Authors: Wu Wenyu , Li Xiaodong , Liu Wenjie , Kang Penglin , Fan Dongqian , Xu Lu , Hu Shuangqi 
Published: August 2024

AbstractImproving the energy density and safety of explosives are crucial for developing composite energetic materials. In this study, a facile and continuous spray drying granulation technique was used to obtain NTO/HMX composite explosives with insensitive NTO as coating material. The micro‐morphology, particle size, crystallographic structure, exothermic decomposition, impact sensitivity, and detonation performance of NTO/HMX composite explosives with different NTO contents were investigated by various experimental methods. The test results indicate that the higher the NTO content, the better the crystal integrity of HMX and the lower the mechanical sensitivity of NTO/HMX composite explosives. When the mass ratio of NTO and HMX is 25 : 75, NTO/HMX composite explosives have a good spherical density structure formed by the aggregation of nanoparticles, small particle sizes with a median size of 1.22 μm, and a uniform distribution of particle sizes in the range of 0.3–2.8 μm. The addition of NTO not only enhances the thermal decomposition of HMX but also significantly decreases mechanical sensitivity. The composite explosives had not altered the raw NTO and HMX crystallographic structures (β‐type). With the same ratio (25 : 75), NTO/HMX composite explosives (25 : 75) possess higher impact energy and friction force, better safety, and better thermal stability than physical mixtures. Additionally, the high‐energy insensitive composite microspheres preserve the important high‐energy properties of HMX while effectively enhancing its safety characteristics, which have the advantages of controllable crystallographic micromorphology, high energy, and excellent impact sensibility and could be broadly applicable in the field of munitions.
Combustible cartridge case material characteristics evaluation
Authors: Jehličková Eliška , Zůbek Vojtěch , Konečný Pavel , Kubát Karel 
Published: August 2024

AbstractCombustible cartridge cases are parts of modular charges used in modern artillery systems. Some types of combustible cartridge case materials have exhibited problems during pyrostatic measurements caused by their difficult ignition. This article explores the possibility of testing the combustible cartridge case material mixed with a propellant of known ballistic properties and then separating the influence of that propellant using methods of mathematical analysis. The aim of this work is to create methodology for closed vessel tests of combustible cartridge case material. Outcome involves the characterization of combustible cartridge case material ballistic properties, including its burn rate parameters. Calculations described in this paper could potentially be modified to be applicable to other cases of mixture of two propellants.
Simulation and fabrication of reactive metamaterials for controllable energy response
Authors: Ichiyama Robert T. , Stanisha Madeleine , Scarpelli Noah P. , Smith James L. , Stewart D. Scott , Oxley Jimmie C. 
Published: August 2024

AbstractSimulations and experiments were conducted to control the shock‐to‐detonation transition by energy trapping in localized regions of nitromethane that contained arrays of embedded dense particles (tantalum rods). The localizations were additively manufactured and designed with simulations carried out with ALE3D, that used the ignition and growth reactive flow model for the explosive. Modelling demonstrated enhanced reactivity when the tantalum rods were present, leading to a detonation that otherwise did not occur for the same strength shock without rods. Experiments that confirmed predictions of the simulation were conducted using Fritz plane wave lenses to drive various input shocks into the system. Photon doppler velocimetry was the primary diagnostic used to measure shock input and reaction progression. These results suggest that it is possible design explosives to localize sensitivity to shock loading within an insensitive material increasing the overall safety of fielded energetic materials.
Fisetin disrupts mitochondrial homeostasis via superoxide dismutase 2 acetylation in pancreatic adenocarcinoma
Authors: Ding Yimin , Xie Dafei , Xu Chengjie , Hu Wenyi , Kong Binyue , Jia Shengnan , Cao Liping 
Published: August 2024

AbstractPancreatic adenocarcinoma (PDAC) is one of the most lethal malignant tumors with an urgent need for precision medicine strategies. The present study seeks to assess the antitumor effects of fisetin, and characterize its impact on PDAC. Multi‐omic approaches include proteomic, transcriptomic, and metabolomic analyses. Further validation includes the assessment of mitochondria‐derived reactive oxygen species (mtROS), mitochondrial membrane potential, as well as ATP generation. Molecular docking, immunoprecipitation, and proximity ligation assay were used to detect the interactions among fiseitn, superoxide dismutase 2 (SOD2), and sirtuin 2 (SIRT2). We showed that fisetin disrupted mitochondrial homeostasis and induced SOD2 acetylation in PDAC. Further, we produced site mutants to determine that fisetin‐induced mtROS were dependent on SOD2 acetylation. Fisetin inhibited SIRT2 expression, thus blocking SOD2 deacetylation. SIRT2 overexpression could impede fisetin‐induced SOD2 acetylation. Additionally, untargeted metabolomic analysis revealed an acceleration of folate metabolism with fisetin. Collectively, our findings suggest that fisetin disrupts mitochondrial homeostasis, eliciting an important cancer‐suppressive role; thus, fisetin may serve as a promising therapeutic for PDAC.
Transportation Vibration Effects on Apple Bruising
Authors: Keyhan Sarvenaz , Shirzad Khadijeh , Almenar Eva , Joodaky Amin 
Published: August 2024

ABSTRACTVibrations during transportation often cause mechanical damage to fresh produce. Addressing or mitigating this damage requires efficient packaging solutions that maintain fresh produce integrity during transit, thereby preserving produce quality and market value. This study investigates the effects of various transportation profiles and packaging designs on apple bruising using simulated truck vibrations. Two apple varieties, Fuji and Jonagold, were packaged in corrugated paperboard boxes with paper pulp trays, plastic crates with paper pulp trays, corrugated paperboard boxes with volume packing and plastic crates with volume packing, all commercial apple packaging. The packaged apples were exposed to two random vibration profiles: leaf spring and air ride suspensions, both set at four different intensities ranging from 0.2 to 0.7 Grms for 1, 3 and 5 h. The findings revealed that both packaging type and vibration parameters significantly influenced apple bruising. Especially, plastic crates with paper pulp trays led to the most severe bruising, whereas corrugated paperboard boxes with volume packing afforded the most protection. Regardless of the packaging design, leaf spring suspension resulted in more apple bruising compared to air ride suspension. The findings of this study provide practical insights for packaging engineers to mitigate the apple bruising during transportation.