bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New N‐(Substituted‐thioureido)aminobicyclo Dicarboximide and 3,4‐Disubstituted 1,2,4‐Triazolino‐5‐thione
Authors: Pachuta‐Stec Anna , Kosikowska Urszula , Mazur Liliana , Swatko‐Ossor Marta , Pitucha Monika , Malm Anna , Ginalskad Grażyna 
Published: December 2013

AbstractThe novel N‐(substituted‐thioureido)aminobicyclo dicarboximide and 3,4‐disubstituted 1,2,4‐triazolino‐5‐thione were synthesized and their antimicrobial and antituberculosis activities were examined. Selected dicarboxylic acid anhydrides were used to obtain derivatives of thiosemicarbazide and dicarboximide. Dicarboximides were also cyclized in the presence of an alkaline solution giving 1,2,4‐triazolino‐5‐thione. The chemical structure of all compounds was confirmed by IR, 1H NMR, 13C NMR, the X‐ray crystallography (6, 11) and elemental analysis. Antimicrobial and antituberculosis activities of the derivatives were measured.
Three‐component One‐pot Synthetic Route to Functionalized N‐Phenyl‐ and N,N‐(1,4‐phenylene)‐2‐alkylimino‐2,3‐dihydrothiazoles under Mild, Solvent‐ and Catalyst‐free Conditions
Authors: Iravani Nasir , Keshavarz Mosadegh , Monfared Maryam , Hosseini Fatemeh 
Published: December 2013

AbstractA simple and efficient one‐pot synthesis of alkyl‐2‐(alkylimino)‐4‐methyl‐3‐phenyl‐2,3‐dihydrothiazole‐5‐carboxylate and dialkyl 3,3′‐(1,4‐phenylene)‐bis‐[2‐(alkylimino)‐4‐methyl‐2,3‐dihydrothiazole‐5‐carboxylate] derivatives from the reaction of phenylisothiocyanate (and also 1,4‐phenylene diisothiocyanate) and primary alkylamines in the presence of 2‐chloro‐1,3‐dicarbonyl compounds is described. This new protocol has several advantages such as lack of necessity of the catalyst and solvent, good yields,mild conditions and short times for reaction.
Company‐Speak: An Inside Perspective on Corporate Language
Authors: Vecchi Dardo De 
Published: December 2013

AbstractIn an increasingly globalized and interconnected world, it is no longer unusual to find several different languages being used in companies and other organizations. It is natural for researchers to pay attention to and explore these multilingual situations. Although equally important, analyses of monolingual situations are less frequent, however, probably because the perceived risk of misunderstanding and conflict is less obvious. In monolingual situations, everybody is supposed to understand everybody else because everybody is speaking the same language. This, however, is not the always the case. Even when people speak the same language, it does not mean that they understand everything that is said. Although “company‐speak''—the internal corporate language of an organization—can act as a bridge, it also can act as a barrier—not only within the company, but also between the company and its customers. © 2014 Wiley Periodicals, Inc.
Disassembly of the cystovirus ϕ6 envelope by montmorillonite clay
Authors: Block Karin A. , Trusiak Adrianna , Katz Al , Gottlieb Paul , Alimova Alexandra , Wei Hui , Morales Jorge , Rice William J. , Steiner Jeffrey C. 
Published: December 2013

AbstractPrior studies of clay–virus interactions have focused on the stability and infectivity of nonenveloped viruses, yielding contradictory results. We hypothesize that the surface charge distribution of the clay and virus envelope dictates how the components react and affect aggregation, viral stability, and infectivity. The bacteriophage Cystoviridae species φ6 used in this study is a good model for enveloped pathogens. The interaction between φ6 and montmorillonite (MMT) clay (the primary component of bentonite) is explored by transmission electron microscopy. The analyses show that MMT–φ6 mixtures undergo heteroaggregation, forming structures in which virtually all the virions are either sequestered between MMT platelet layers or attached to platelet edges. The virions swell and undergo disassembly resulting in partial or total envelope loss. Edge‐attached viral envelopes distort to increase contact area with the positively charged platelet edges indicating that the virion surface is negatively charged. The nucleocapsid (NCs) remaining after envelope removal also exhibit distortion, in contrast to detergent‐produced NCs which exhibit no distortion. This visually discernible disassembly is a mechanism for loss of infectivity previously unreported by studies of nonenveloped viruses. The MMT‐mediated sequestration and disassembly result in reduced infectivity, suggesting that clays may reduce infectivity of enveloped pathogenic viruses in soils and sediments.
A critical role for the long non‐coding RNA GAS5 in proliferation and apoptosis in non‐small‐cell lung cancer
Authors: Shi Xuefei , Sun Ming , Liu Hongbing , Yao Yanwen , Kong Rong , Chen Fangfang , Song Yong 
Published: December 2013

AbstractIn more recent years, long non‐coding RNAs (lncRNAs) have been investigated as a new class of regulators of cellular processes, such as cell growth, apoptosis, and carcinogenesis. Although lncRNAs are dysregulated in numerous cancer types, limited data are available on the expression profile and functional role of lncRNAs in non‐small cell lung cancer (NSCLC). In the present study, we determined the expression pattern of the growth arrest‐specific transcript 5 (GAS5) in 72 NSCLC specimens by qRT‐PCR and assess its biological functions in the development and progression of NSCLC. The results revealed that GAS5 expression was down‐regulated in cancerous tissues compared to adjacent noncancerous tissues (P < 0.05) and was highly related to tumor size and TNM stage (P < 0.05). This correlation between GAS5 and clinicopathological parameters indicates that GAS5 might function as a tumor suppressor. Furthermore, GAS5 overexpression increased tumor cell growth arrest and induced apoptosis in vitro and in vivo. Meanwhile, siRNA‐mediated knockdown of GAS5 promoted tumor cell growth. Importantly, through western blot analysis, we found that ectopic expression of GAS5 significantly up‐regulated p53 expression and down‐regulated transcription factor E2F1 expression. Taken together, these findings suggest that GAS5 is a tumor suppressor in NSCLC, and the action of GAS5 is mediated by p53‐dependent and p53‐independent pathways. GAS5 could serve as a potential diagnostic marker for NSCLC and may be a novel therapeutic target in patients with NSCLC. © 2013 Wiley Periodicals, Inc.
The Role of Inner Strength in Quality of Life and Self‐Management in Women Survivors of Cancer
Authors: Dingley Catherine , Roux Gayle 
Published: December 2013

AbstractThe role of inner strength in quality of life (QOL) and self‐management, primary variables in the Theory of Inner Strength, were examined with demographic and clinical characteristics in 107 women with cancer. The strongest predictors of QOL were depressive symptoms, inner strength, and time since diagnosis, respectively, accounting for 82% of the variance in QOL. When depressive symptoms were excluded due to multicollinearity, 64% of variance in QOL was explained by inner strength, time since diagnosis, and comorbidities, with inner strength the strongest predictor. The strongest predictors of self‐management were depressive symptoms and inner strength, accounting for 17% of the variance. Results contribute to theory development and suggest the value of supporting inner strength to enhance QOL in cancer survivors. © 2013 Wiley Periodicals, Inc.
Elevated delta OD 450 due to transient abnormal myelopoiesis in a Down syndrome fetus with hepatosplenomegaly on ultrasound
Authors: Mancuso Abigail , Rijhsinghani Asha 
Published: December 2013

ABSTRACTTransient abnormal myelopoiesis (TAM) is a relatively common finding in children with Down syndrome but has also been diagnosed prenatally, most often presenting with fetal hepatosplenomegaly. We report a case of TAM with hepatosplenomegaly found on ultrasound and associated with an increased amniotic fluid Δ OD 450 value. TAM is most commonly transient but can be associated with fatality and therefore should be considered in the differential diagnosis when fetal hepatosplenomegaly is found on ultrasound. Amniocentesis with chromosomal analysis and a Δ OD 450 may aid in diagnosing TAM and predicting the severity of the liver involvement. © 2013 John Wiley & Sons, Ltd.
Including the effects of pressure and stress in thermodynamic functions
Authors: Hammerschmidt T. , Abrikosov I. A. , Alfè D. , Fries S. G. , Höglund L. , Jacobs M. H. G. , Koßmann J. , Lu X.‐G. , Paul G. 
Published: December 2013

AbstractMost applications of thermodynamic databases to materials design are limited to ambient pressure. The consideration of elastic contributions to thermodynamic stability is highly desirable but not straight‐forward to realise. We present examples of existing physical models for pressure‐dependent thermodynamic functions and discuss the requirements for future implementations given the existing results of experiments and first‐principles calculations. We briefly summarize the calculation of elastic constants and point out examples of nonlinear variation with pressure, temperature and chemical composition that would need to be accounted for in thermodynamic databases. This is particularly the case if a system melts from different phases at different pressures. Similar relations exist between pressure and magnetism and hence set the need to also include magnetic effects in thermodynamic databases for finite pressure. We present examples to illustrate that the effect of magnetism on stability is strongly coupled to pressure, temperature, and external fields. As a further complication we discuss dynamical instabilities that may appear at finite pressure. While imaginary phonon frequencies may render a structure unstable and destroy a crystal lattice, the anharmonic effects may stabilize it again at finite temperature. Finally, we also outline a possible implementation scheme for strain effects in thermodynamic databases.
Temperature dependence of anisotropic displacement parameters in O3‐type NaM O2 (M = Cr and Fe): Comparison with isostructural LiCoO2
Authors: Tanabe D. , Shimono T. , Kobayashi W. , Moritomo Y. 
Published: December 2013

AbstractO3‐type NaM O2 (M = Cr and Fe) is a promising cathode material for sodium ion secondary batteries (SIBs). Here, we investigate the temperature dependence of anisotropic displacement parameters, U33 and U11, in NaM O2 by synchrotron radiation X‐ray powder diffraction measurements. In both compounds, the displacement ratios $(r \equiv \sqrt {U_{33} /U_{11} } - 1)$ for M and O are positive, reflecting the out‐of‐plane thermal displacement of the M O2 layer. On the other hand, the r value for Na is negative, reflecting the two‐dimensional (2D) host structure. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A linear parameter varying fault detection and isolation method for internal combustion spark ignition engines
Authors: Casavola Alessandro , Famularo Domenico , Gagliardi Gianfranco 
Published: December 2013

SUMMARYIn this paper, we propose a fault detection and isolation filter design method for internal combustion spark ignition engines. Starting from a detailed nonlinear mean‐value mathematical description of the engine, a novel linear parameter varying (LPV) model approximation is derived on the basis of a judicious convex interpolation of a family of linearized models. A filter structure consisting of a bank of LPV observers is considered, each of them in charge of detecting a particular class of faults and exhibiting low sensitivity to all other faults and exogenous inputs. The resulting diagnostic filter is parameter‐dependent in that a set of measurable engine variables is used online to suitably modify the filter gain so as to better take care of system nonlinearities. The quality of the LPV model approximation of the engine and the diagnostic capabilities of the fault detection and isolation architecture are demonstrated by a series of extensive numerical simulations. Copyright © 2013 John Wiley & Sons, Ltd.
A Cell of Origin Gene Signature Indicates Human Bladder Cancer Has Distinct Cellular Progenitors
Authors: Dancik Garrett M. , Owens Charles R. , Iczkowski Kenneth A. , Theodorescu Dan 
Published: December 2013

Abstract
There are two distinct forms of urothelial (bladder) cancer: muscle-invasive (MI) and nonmuscle invasive (NMI) disease. Since it is currently believed that bladder cancer arises by transformation of urothelial cells of the basal layer, bladder cancer stem cells (CSCs) have been isolated based on expression markers found in such cells. However, these CSCs have only been identified in MI tumors raising the intriguing hypothesis that NMI tumor progenitors do not arise from the basal compartment. To test this hypothesis, we carried out genome-wide expression profiling of laser capture microdissected basal and umbrella cells, the two most histologically distinct cell types in normal urothelium and developed a cell of origin (COO) gene signature that distinguishes these. The COO signature was a better predictor of stage and survival than other bladder, generic, or breast CSC signatures and bladder cell differentiation markers in multiple patient cohorts. To assess whether NMI and MI tumors arise from a distinct progenitor cell (DPC) or common progenitor cell, we developed a novel statistical framework that predicts COO score as a function of known genetic alterations (TP53, HRAS, KDM6A, and FGFR3) that drive either MI or NMI bladder cancer and compared this to the observed COO score of the tumor. Analysis of 874 patients in five cohorts established the DPC model as the best fit to the available data. This observation supports distinct progenitor cells in NMI and MI tumors and provides a paradigm shift in our understanding of bladder cancer biology that has significant diagnostic and therapeutic implications. Stem Cells 2014;32:974–982
Experimental investigation on structural performance of mega column to spandrel beam connections used in high‐rise building
Authors: Choi Kyoung‐Kyu , Shin Dong‐Woo , Park Hong‐Gun 
Published: December 2013

SUMMARYIn this paper, a new type of concrete mega column to steel spandrel beam connection was developed for the application to a high‐rise building under construction in Korea. To transfer shear force from the spandrel beams to columns, shear connectors were used, which are steel subassemblies composed of embed plates, connection plates, dowel bars and bearing plates. Experimental studies were performed using two test specimens with a 1/5 scale; in one test specimen, dowel bars welded on embed plates in a column were used, while in the other test specimen, both dowel bars and bearing plates were used. According to the test results, the design methods of the current design codes used in this study effectively addressed the failure mechanisms of the mega column‐spandrel beam connections, and the test specimens developed greater strengths than those evaluated by the current design codes. It was also found that the use of bearing plates at the connections significantly reduces the number of dowel bars used for shear transfer purposes. Copyright © 2013 John Wiley & Sons, Ltd.
Total Synthesis of Hibarimicinone, a v‐Src Tyrosine Kinase Inhibitor Possessing the Pseudo‐Dimer Structure of Tetracycline
Authors: Tatsuta Kuniaki , Hosokawa Seijiro 
Published: December 2013

AbstractThe total synthesis of hibarimicinone, a potent v‐Src tyrosine kinase inhibitor possessing thirteen stereogenic centers and an axial chirality, has been achieved. The key step to constructing the eight‐ring skeleton was the double Michael–Dieckmann‐type cyclization (Hauser annulation) using a thiolactone pseudo‐dimer. These synthetic studies indicated the efficiency of the thiolactone‐employed route to synthesize the multiply functionalized polycyclic compounds. The ABCD‐ring moiety including the bridging ether was constructed by a strategy including oxidation of the C‐ring hydroquinone and the subsequent transfer of the oxidation stage to the neighboring ring. The atropisomer of hibarimicinone was also synthesized to confirm the structure of the natural product.
Triazole‐Linked Analogues of DNA and RNA (TLDNA and TLRNA): Synthesis and Functions
Authors: Isobe Hiroyuki , Fujino Tomoko 
Published: December 2013

AbstractClick chemistry has provided us with access to DNA and RNA analogues with non‐natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non‐cleavable linkages protect the oligomers against nuclease digestion. This account reviews the progress of the triazole‐linked analogues over the past five years. Reinforced by their synthetic robustness, these analogues may find various utilities as tools for exploratory research.
Comparison of Two Models of Surgical Care for Patients with Cleft Lip and Palate in Resource‐challenged Settings
Authors: Rossell‐Perry Percy , Segura Eddy , Salas‐Bustinza Lorgio , Cotrina‐Rabanal Omar 
Published: December 2013

AbstractBackgroundThe Peruvian health system is limited in providing specialized care for patients with clefts because there are an insufficient number of hospitals and few specially trained doctors in rural areas of the country. The most common model of care in these areas is the surgical mission wherein experienced cleft surgeons perform surgeries and teach local doctors. The purpose of this research was to identify the differences in outcome between the surgical mission trip and the referral center model of care provided by the same team.MethodsA retrospective analysis (2002–2012) was performed on data from surgical outcomes provided by the Outreach Surgical Center Lima that utilized both models of care (surgical mission and referral center). A total of 935 procedures were performed in 680 patients with clefts who were treated by the Outreach Surgical Center Program Lima since 2002. Patients in both groups were identified from our records (medical records and screening‐day registries). All patients underwent a physical examination, had photographs taken, and any unfavorable results and complications were documented. Comparison of categorical variables (including outcomes) between care models was performed using Pearson’s χ2 test or Fisher’s exact test when appropriate. In all cases a two‐tailed test was performed and the p value for rejecting the null hypothesis (no difference or no association) was set at 0.05.ResultsWe found significant differences between the two models of care with respect to unilateral cleft lip and cleft palate dehiscence (p = 0.02 and p = 0.04, respectively), palate postoperative hemorrhage (p < 0.01), and palatal fistula (p < 0.01) outcomes.DiscussionDifferences in observed surgical outcomes between the two models might be attributed to the surgeon’s performance and/or the patient’s age, and these factors are also considered with respect to the model of care. Limitations in long‐term medical evaluation at each site should be identified and strategies to improve surgical outcomes must be developed to ensure that patients served by surgical missions obtain the same results achieved at a referral center.Level of EvidenceTherapeutic III.
Neuropharmacological functional imaging
Authors: Thiel C. 
Published: December 2013

Abstract
The marriage of psychopharmacology with functional neuroimaging enables the investi­gation of neurochemical modulation of cognitive functions in the human brain. From the point of basic neurocognitive research, pharmacological functional neuroimaging is hence a valuable completion of animal experiments. From the point of clinical neuro­science, pharmacological neuroimaging con­tributes to the understanding and development of pharmacological treatment ap­proaches for patients with neurological and psychiatric disorders. The present paper prov­ides an overview of the methodological approach and illustrates research findings and recent developments from pharmacological functional magnetic resonance imaging studies by means of selective examples from the dopaminergic and cholinergic neurotrans­mitter system.
The Dialectics of Remembrance: Memories of Empire in Cold War Japan
Authors: Conrad Sebastian 
Published: December 2013

AbstractBetween 1895 and 1945 Japan assembled one of the largest empires in modern world history. It vanished abruptly in the summer of 1945 at the end of the Second World War, and seemed to leave no trace in public consciousness. Historians, too, have portrayed postwar Japan as characterized by a virtual erasure of the imperial past. This article draws on recent scholarship to argue that things were more complicated than that. While references to the imperial past indeed dwindled after about 1960, immediate forgetting did not exhaust the reactions by individuals and interest groups. Some social milieus experienced the dissolution of the empire much more profoundly than official discourse would suggest. Since the mid-1990s, Japan's imperial past has reemerged as a major field of historical inquiry and a more general concern in public debate. In this article I situate the dialectic of remembering and forgetting within larger processes and transformations of the postwar order in East Asia, in particular the American occupation and the emergence of the Cold War.
New infection rate of bovine mammary glands after application of an internal teat seal at dry-off
Authors: Krömker Volker , Grabowski Nils Th. , Friedrich Julia 
Published: December 2013

The internal teat sealant OrbeSeal® (Zoetis, Berlin, Germany) is intended to prevent new intramammary infection (IMI) throughout the dry period. The aim of this field study was to determine new infection rates in udder quarters applied exclusively with the sealant at dry-off and untreated ones (control group). For that, the new infection rate of udder quarters treated with the sealant was evaluated in a split-udder design (front right and rear left udder quarters treated, the other ones untreated) in 128 cows from nine dairy farms in North Germany that were healthy in all four udder quarters (i.e. <100 000 cells/ml, bacteriologically negative). After calving, duplicate quarter milk samples were collected twice at DIM (days in milk) 5–12 and 7 d later for culture. The new infection rates for treated and untreated groups were 3·4 and 10·5%, respectively. The results showed that applying a standardised study design with very few confounders under field conditions, using internal teat sealants reduced the new infection rate on quarter level to a third of that of the control group. Thus, internal teat sealants represent a viable option for dry-off treatment of udder-healthy cows.
The Value of (Stock) Liquidity in the M&A Market
Authors: Massa Massimo , Xu Moqi 
Published: December 2013

AbstractWe study the value of stock liquidity in the market for corporate control and show that the target firm’s liquidity has an impact on the transaction itself and on the resulting merged entity. We use a sample of U.S. merger and acquisition (M&A) transactions (1987–2007) to show that acquiring a more liquid firm makes the stock of the acquirer more liquid. This has consequences for M&A activity and pricing. Public acquirers are more likely than private acquirers to acquire more liquid targets. Liquidity also translates into a greater likelihood of completing the deal and higher compensation for the target.