bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway
Authors: Zhou Di-Shu , Zhang Wei-Jian , Song Shu-Ya , Hong Xin-Xin , Yang Wei-Qin , Li Juan-Juan , Xu Jian-Qu , Kang Jian-Yuan , Cai Tian-Tian , Xu Yi-Fei , Guo Shao-Ju , Pan Hua-Feng , Li Hai-Wen 
Published: July 2024

BACKGROUND
Gastric intestinal metaplasia (IM) is a precancerous lesion that is associated with an elevated risk of gastric carcinogenesis. Weiwei Decoction (WWD) is a promising traditional Chinese herbal formula widely employed in clinical for treating IM. Previous studies suggested the potential involvement of the olfactomedin 4 (OLFM4)/nucleotide-binding oligomerization domain 1 (NOD1)/caudal-type homeobox gene 2 (CDX2) signaling pathway in IM regulation.
AIM
To verify the regulation of the OLFM4/NOD1/CDX2 pathway in IM, specifically investigating WWD’s effectiveness on IM through this pathway.
METHODS
Immunohistochemistry for OLFM4, NOD1, and CDX2 was conducted on tissue microarray. GES-1 cells treated with chenodeoxycholic acid were utilized as IM cell models. OLFM4 short hairpin RNA (shRNA), NOD1 shRNA, and OLFM4 pcDNA were transfected to clarify the pathway regulatory relationships. Protein interactions were validated by co-immunoprecipitation. To explore WWD’s pharmacological actions, IM rat models were induced using N-methyl-N’-nitro-N-nitrosoguanidine followed by WWD gavage. Gastric cells were treated with WWD-medicated serum. Cytokines and chemokines content were assessed by enzyme-linked immunosorbent assay and quantitative reverse transcription polymerase chain reaction.
RESULTS
The OLFM4/NOD1/CDX2 axis was a characteristic of IM. OLFM4 exhibited direct binding and subsequent down-regulation of NOD1, thereby sustaining the activation of CDX2 and promoting the progression of IM. WWD improved gastric mucosal histological lesions while suppressing intestinal markers KLF transcription factor 4, villin 1, and MUCIN 2 expression in IM rats. Regarding pharmacological actions, WWD suppressed OLFM4 and restored NOD1 expression, consequently reducing CDX2 at the mRNA and protein levels in IM rats. Parallel regulatory mechanisms were observed at the protein level in IM cells treated with WWD-medicated serum. Furthermore, WWD-medicated serum treatment strengthened OLFM4 and NOD1 interaction. In case of anti-inflammatory, WWD restrained interleukin (IL)-6, interferon-gamma, IL-17, macrophage chemoattractant protein-1, macrophage inflammatory protein 1 alpha content in IM rat serum. WWD-medicated serum inhibited tumor necrosis factor alpha, IL-6, IL-8 transcriptions in IM cells.
CONCLUSION
The OLFM4/NOD1/CDX2 pathway is involved in the regulation of IM. WWD exerts its therapeutic efficacy on IM through the pathway, additionally attenuating the inflammatory response.
Gastric cancer metastatic to the breast: A case report
Authors: Liu Jia-Hui , Dhamija Gaurav , Jiang Yi , He Dan , Zhou Xiao-Cong 
Published: July 2024

BACKGROUND
Metastatic breast cancer originating in the gastrointestinal tract is a rare occurrence. The limited number of cases has resulted in incomplete understanding of the disease, making it challenging to differentiate from primary breast cancer. While clinical history and immunohistochemical studies can aid in distinguishing between the two, the management principles and pathogenesis of gastrointestinal metastatic breast cancer remain controversial. The scarcity of data has hampered comprehensive knowledge. Our objective is to shed light on this rare disease through our case study.
CASE SUMMARY
Here, we report a case of breast metastasis from gastric cancer in a 43-year-old woman. This patient was admitted to our hospital with complaints of discomfort in the upper and middle abdomen persisting for two months, as well as black stools for over ten days. She underwent radical distal gastrectomy for gastric cancer, followed by postoperative chemotherapy. Three years later, the patient developed bilateral breast nodules. Imaging studies indicated a high probability of malignancy. She subsequently underwent a right modified radical mastectomy and excision of a left breast mass. Postoperative pathology revealed the right breast tumor was consistent with primary gastric cancer.
CONCLUSION
We present a case of breast metastasis from gastric cancer to contribute to the limited foundation of research into this rare disease.
BRAF K601E-mutated metastatic colorectal cancer in response to combination therapy with encorafenib, binimetinib, and cetuximab: A case report
Authors: Sasaki Makiko , Shimura Takaya , Nishie Hirotada , Kuroyanagi Keita , Kanno Takuya , Fukusada Shigeki , Sugimura Naomi , Mizuno Yusuke , Nukui Takayuki , Uno Konomu , Kojima Yuki , Nishigaki Ruriko , Tanaka Mamoru , Ozeki Keiji , Kubota Eiji , Kataoka Hiromi 
Published: July 2024

BACKGROUND
BRAF mutation has been recognized as a negative prognostic marker for metastatic colorectal cancer (mCRC), but these data are from common BRAF V600E-mutated mCRC. Combination therapy of BRAF inhibitor and anti-epidermal growth factor receptor (EGFR) antibody has been approved for BRAF V600E-mutated mCRC. However, BRAF non-V600 mutations are rare mutations, and their clinical behavior is not understood. Moreover, the BRAF K601E mutation is extremely rare in mCRC, and there have been no reports on its specific treatment.
CASE SUMMARY
Herein, we report the case of a 59-year-old female with super aggressive mCRC with multiple metastases, which extended to whole body including mediastinal to abdominal lymph nodes, bones, pleura, and peritoneum. The companion diagnostics of tumor tissues showed RAS/BRAF wild-type without microsatellite instability. She received chemotherapy with mFOLFOX6 (oxaliplatin plus infusional 5-fluorouracil [5-FU] and leucovorin) plus panitumumab, following FOLFIRI (irinotecan plus infusional 5-FU and leucovorin) plus ramucirumab. For the next regimen selection, a comprehensive genomic profiling panel was performed and revealed a BRAF K601E mutation, which was not covered in the initial companion diagnostics. After disease progression, a combination of encorafenib, binimetinib, and cetuximab was selected as third-line chemotherapy. The serum levels of tumor markers were immediately decreased accompanied by improvements in pleural effusion and ascites. However, the disease progressed again, and best supportive care was done instead.
CONCLUSION
This case offers novel insights into the clinical behaviors of BRAF non-V600E-mCRC, potentially advancing personalized therapy for rare and aggressive cases.
BO‘LAJAK PEDAGOGLARDA KASBIY DEFORMARSIYANI RIVOJLANTIRISHNING PEDAGOGIK PSIXOLOGIK USULLARI
Authors: To’lanova Mahliyo 
Published: July 2024

Ushbu maqolada oliy ta’lim muassasalarida kasbiy rivojlanishni takomillashtirish va ta'lim sohasidagi munosabatlar va ishtirokchilar o'rtasidagi deformatsiya (mehnatga moslashish, ko’nikish) amaliyotning ilmiy va amaliy tadqiqotlariga bag'ishlangan. Talabalarda kasbiy deformatsiya yondashuvning o‘rni va ahamiyati haqida so‘z yuritiladi. Mamlakatimizni iqtisodiy, siyosiy va ma’naviy jixatdan ertangi kuni hisoblangan bo‘lajak pedagoglarni o‘z kasbini mohir ustasi bo‘lib yetishishi uchun tavsiyalar berilgan.
Rejection of Application for Registration of Trademark Payfazz Agen Keuangan Nusantara Based on Law Number 20 Year 2016: Penolakan Permohonan Pendaftaran Merek Dagang Payfazz Agen Keuangan Nusantara Berdasarkan Undang-Undang Nomor 20 Tahun 2016
Authors: Agriansyah Herdi 
Published: July 2024

The principle of trademark registration in Indonesia is first to file, i.e. who first registers his trademark is considered as the owner or holder of rights to the trademark. Trademark registration should not be based on bad faith, because in Law Number 20 of 2016 concerning Trademarks and Geographical Indications, the application for trademark registration must be rejected. The purpose of this study is to determine the refusal of the application for registration of the Payfazz Agen Keuangan Nusantara trademark based on Law Number 20 of 2016 concerning Trademarks and Geographical Indications in Decision Number 25/Pdt.Sus-Merek/2020/Pn.Niaga.Jkt.Pst and to determine the legal consequences of the refusal of the application for registration of the Payfazz Agen Keuangan Nusantara trademark based on Law Number 20 of 2016 concerning Trademarks and Geographical Indications in Decision Number 25/Pdt.Sus-Merek/2020/Pn.Niaga.Jkt.Pst. This research uses a normative juridical approach method with analytical descriptive research specifications. The data collection method is done by literature study, the data obtained is presented with narrative text, and the data analysis method used is qualitative normative method. The results of the research can be concluded that the refusal of the application for registration of the mark “PAYFAZZ AGENT FINANCIAL OBLIGATIONS NUSANTARA‘’ which was rejected by the Defendant was appropriate in accordance with the provisions of Article 21 paragraph (1) letter b of Law Number 20 of 2016 concerning Trademarks and Geographical Indications and the legal consequences of the refusal of registration of the mark ‘PAYFAZZ AGENT FINANCIAL OBLIGATIONS NUSANTARA’' is that the Plaintiff has lost the right, interests, and benefits under the law arising from the Trademark ''PAYFAZZ OBLIGATORY FINANCIAL AGENT NUSANTARA'', and has suffered immaterial losses because the problems with the registration of the Trademark ''PAYFAZZ OBLIGATORY FINANCIAL AGENT NUSANTARA'' took up a lot of time, costs, energy, and thoughts of the Plaintiff, because the Defendant erred in applying the applicable law.
تطبيق الطريقة الانتقائية بوسيلة الأفلام العربية في تدريس الإملاء "دراسة تجريبية في الصف الثاني بالمدرسة المتوسطة المدنى العزيزية Aceh Besar"
Authors: Ulil abshariyah  , Tarmizi Ninoersy  , Muhammad Ridha  
Published: July 2024

Based on the researcher’s observation that some students in the second grade of the junior high school feel difficult to learn dictation and do not understand the lesson when the process of teaching and learning is that they do not focus while they speak and laugh between them in the classroom, and this is the reason that some of them do not understand the lesson and some of them can understand the lesson, but it is difficult to distinguish write whose exits are equal to the write ت andة . Therefore, the researcher tries to overcome these problems by applying the selective method of Arabic films in teaching dictation. The objectives of this research were to know the effectiveness of the selective method of Arabic films in teaching dictation at the Al-Madani Al-Aziziyah Junior High School Aceh Besar and to introduce the activities of the teacher and students when applying the selective method by means of Arabic films in learning Dictation in the Al-Madani AL-Aziziyah Junior High School Aceh Besar The researcher uses the one-group pre-test post-test design, the researcher presents observation paper, tribal testing, and dimensional testing as research tools. The result of applying the selective method in the Arabic film method in teaching dictation in the second grade of the Junior High School Aceh Besar got an excellent score, in the activities of the teacher with a score of 92.5% and in the activities of students with a score of 92.5%، When analyzing observation data. The application of the selective method by the Arabic film method is effective in teaching dictation, and the researcher relies that the result of the test ( Paired Sample T-Test) obtained the result level of significance ( sig.2-tailed 0,000 )، It is smaller than the result of the indication level ( 0,005 ), indicating that zero assumption is cost-effective and alternative imposition is acceptable. It indicates that the application of the selective method by Arabic films is effective in teaching dictation.
وسيلة قرص الساعة وفعاليتها لترقية قدرة الطالبات على فهم العدد والمعدود (دراسة تجريبية بـMTs Nurul Islam Peudada )
Authors: FAJRIAH  , Suci Hijriati  
Published: July 2024

The problem in the process of learning Arabic in grade 2 (b) at MTs Nurul Islam Peudada is that the students are not able to understand ‘adad and ma’dud. Some students have difficulty adjusting between‘adad and ma’du. This research aims to identify the effectiveness the use of wall clock media to increase students’ ability to understand ’adad and ma’dud in grade 2 (b) at MTs Nurul Islam Peudada. The research method in this research is pre experimental method with the one group pre-test and post-test design. To collect the data, the researcher used the test. The result of this research is the using of wall clock media is effective to increase students’ ability to understand ’adad and ma’dud . Furthermore, it was found that the result of the T-Test is a significance level (2- tailed) 0.00<0.05. This value shows that the alternative hypothesis (Ha) is accepted and the null hypothesis (H0) is rejected.
الأصوات اللغوية عند سيبويه
Authors: Putri Rahmawati  
Published: July 2024

The aim of this paper is to describe thought of Sibawaih about sounds of language in terms of classical Arabic literature. Sibawaih is a traditional linguist who has great reputation and influence on development of Arabic linguistics. This is due to his expertise in Arabic linguistic theories as reflected in one of his works, KitÄb Sibawaih (The Book of Sibawaih) or al-KitÄb. The problems about sounds of language also discussed in that book. Sibawaih discuss about sounds of language in volume 4 of the Sibawaih book, especially in the chapter Idgham. Sibawaih examines the sounds of language in terms of the number of sounds in Arabic language , point of articulation, and characteristics of sound language. Some thought of Sibawaih are different with the opinion of modern linguists and this paper try to present interesting side from thought of Sibawaih in relation to sounds of language
Complicaciones post trasplante hepático en pacientes pediátricos en un hospital de tercer nivel, Lima-Perú, 2016-2020
Authors: Castro-Johanson Rosa , Tello Quispe Gabriela , Verastegui S. Rodrigo , Perez Rodriguez Diana 
Published: July 2024

Objetivo: Determinar las complicaciones durante el primer año post trasplante hepático en pacientes pediátricos del Instituto Nacional de Salud del Niño-San Borja (INSN-SB) durante el periodo 2016-2020. Materiales y métodos: Estudio descriptivo, transversal. Se revisaron las historias clínicas de los pacientes trasplantados hepáticos atendidos durante el seguimiento post trasplante en el INSN SB recolectándose características epidemiológicas, indicación de trasplante; puntaje PELD, score CHILD y complicaciones previas al trasplante, así como la frecuencia de las principales complicaciones presentadas durante el primer año post trasplante. Resultados: De los 16 pacientes evaluados, el 62,5% fueron menores de 1 año, siendo la mediana de peso 7,4 kg, el 50% presentó un score CHILD C, la mediana de PELD de 23. El principal motivo de trasplante fue atresia de vías biliares (62,5%). Las principales complicaciones previas al trasplante fueron la hipertensión portal (75%) y la desnutrición (68,8%). Todos los pacientes post trasplantados presentaron al menos una complicación infecciosa: bacteriana (53%), infección por CMV (75%) e infección por EBV (31%); en relación a las complicaciones vasculares, 25% presentaron trombosis de vena porta y un paciente (6%) presentó estenosis de arteria hepática; con respecto a las complicaciones biliares, el 12,5% presentaron fístula biliar, también el 12,5% presentaron dilatación de la vía biliar, mientras que el 6,25% presentó bilioma. Conclusiones: Dentro de las principales complicaciones del paciente post trasplantado hepático podemos destacar que todos los pacientes presentaron al menos una complicación infecciosa (100%), complicaciones vasculares el 31% y complicaciones biliares en el 31,25% de los pacientes.
Determinants of Women’s Participation in Community Development Projects in Mandera County, Kenya
Authors: Gedi Bishar , Abuga Isaac 
Published: July 2024

Purpose: The purpose of the study is to investigate the determinants Of Women Participation In Community Development Projects In Mandera County, Kenya.
Methodology: Descriptive survey research design was used. The target population of the study was est. 10,000 eligible women involved in various projects in the six (6) constituencies across Mandera County. A simple random sampling and a total of 207 respondents selected as the study sample. Primary data was collected via questionnaires issued by drop and pick method. Quantitative data collected was analyzed using descriptive and inferential statistics. The data was presented in form of tables, graphs, and pie charts. Correlation analysis was conducted to assess the strength of the relationship between the independent and dependent variables. Regression analysis was employed to establish factors determining women's participation in community development projects in Mandera County, Kenya.
Results: The study concludes that socio-cultural practices, education and political factors have a direct influence on women participation in community-based projects. Specifically, Socio cultural practices and politics were found to be the major impediments to women participation in community projects while education was found to be an impetus. The study calls for government to fast track implementation of the existing legal framework against retrogressive socio-cultural practices such as FGM and early marriages, to enact more laws that promote and guarantee women and other minority groups' education and inclusion in running of both the private and the public sector.
Unique Contribution to Theory and Practice: Further studies were recommended on impediments of actualization of gender equality in political leadership in in Kenya. A replication of this study is recommended but in different communities across the country and in both the African and Asian continents. This is to inform generalization of this study findings.
Morbidity of Complicated Gallstone Disease with Surgical Management: Comparison between Laparoscopic and Open Cholecystectomy
Authors: Bushra Ghulam  , Shabbir Ahmed  , Muhammad Mumtaz Ather  , Aamir Javid  , Shoiab Anwar  , Usama Ali  
Published: July 2024

Objective: To compare the outcomes of laparoscopic cholecystectomy with open cholecystectomy in patients with complicated gallstone disease.
Methodology: This prospective, randomized controlled trial study conducted at the general surgery department, Bakhtawar Amin Medical and Dental College Multan from January 2021 to December 2022, focused on patients with complicated gallstone disease diagnosed on basis of ultrasonography the patients were divided into two groups, Group A for open cholecystectomy and Group B for laparoscopic cholecystectomy by simple randomization method. Main variables of study were post-operative infection, pain score, hospital stay and mobilization time. SPSS version 27 was used for data analysis.
Results: Severity of pain was mild in 16 (17.8%) and 29 (32.2%) patients of OC and LC groups respectively. Whereas, pain was severe in 28 (31.1%) and 25 (27.8%) patients of OC and LC groups respectively, (p=0.076). According to complications, chest infection was most common in 30 (33.3%) LC group, (p<0.001). The average mobilization time in OC and LC groups was 16.78±8.51 hours and 15.78±9.74 hours, respectively, (p=0.469). While, length of hospital stay in OC was higher than LC group, 5.91±2.45 days and 2.97±1.89 days, respectively. (p<0.001).
Conclusion: Laparoscopic cholecystectomy is a safe and effective treatment for complicated gallstone disease in many cases. It offers several advantages, including minimal invasiveness, shorter hospitalization, early mobilization, and faster recovery. However, the decision on the surgical approach should be individualized based on the patient's specific condition and the surgeon's judgment.
ORE DEPOSITS OF RIFT STRUCTURES
Authors: Машковцев Г.А. , Коротков В.В. , Руднев В.В. 
Published: July 2024

В статье рассмотрены геология, история развития и рудоносность разновозрастных рифтогенных структур, к которым отнесены системы рифтов океанических зон спрединга, континентальные и межконтинентальные рифты, а также зеленокаменные пояса. Сравнительный анализ и сопоставление этих структур показал, что, несмотря на различную геотектоническую позицию, условия и время их формирования, процессы рудообразования принципиально близки. Установлено проявление дофанерозойских рифтогенных процессов в пределах тектонически ослабленной Байкало-Становой зоны южного обрамления Сибирской платформы и Восточно-Европейского кратона, в ходе которых сформировались крупные месторождения железисто-кварцитовых руд, а также золота, меди, редких и других металлов. Приведены данные по геологии и проявлению современного гидротермально-осадочного рудообразования в илах морского дна рифтогенной структуры Красного моря, которая может рассматриваться в качестве природной лаборатории для понимания условий образования продуктивных рифтогенов предшествующих геологических эпох.
The article presents the geology, history of development and ore content of rift structures of different ages, which include rift systems of oceanic spreading zones, continental and intercontinental rifts, as well as greenstone belts. A comparative analysis and comparison of these structures showed that, despite the different geo-tectonic position, conditions and time of their formation, the processes of ore formation are fundamentally similar. The manifestation of pre-Phanerozoic rifting processes has been established within the tectonically weakened Baikal-Stanovoy zone of the southern border of the Siberian formation and the East European craton, during which large ferruginous-quartzite deposits, as well as gold, copper, rare, etc. were formed. metals. The article concludes with data on the geology and manifestation of modern hydrothermal sedimentary ore formation in the silts of the seabed of the riftogenic structure of the Red Sea, which can be considered as a natural laboratory for understanding the conditions for the formation of productive riftogens of previous geological epochs.