bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurovascular crossing patterns between leash of Henry and deep branch of radial nerve: implications for neurointervention and diagnostic imaging
Authors: Mohana-Borges Aurea V. R. , Silva Livia Tavane S. D. , Mohana-Borges Ronaldo S. , Statum Sheronda , Jerban Saeed , Wu Yuanshan , Barrère Victor , Souza Sergio A. L. , Chung Christine B. 
Published: July 2024

Abstract

Objective
To detail the neurovascular crossing patterns between the leash of Henry (LoH) and the deep branch of the radial nerve (DBRN) in supination and pronation of the forearm, using imaging methods with anatomic correlation.

Materials and methods
This cross-sectional study was performed ex vivo with HRUS and MRI with anatomic correlation on 6 samples and in vivo with HRUS with Doppler on 55 participants scanned bilaterally. The in vivo participants were enrolled over a 6-month period. The crossing patterns between the LoH and DBRN were assessed ex vivo and in vivo. Additional morphological features of the DBRN, LoH, and fat plane were assessed in vivo only. Biometric features of the participants were recorded. Statistical analyses were performed using Shapiro–Wilk, parametric and non-parametric tests.

Results
The most common neurovascular crossing pattern was the ascending branch of the radial recurrent artery (RRAab) crossing below (ex vivo: 83.3%, in vivo: 85.3%) and the muscular branch crossing above (ex vivo: 100%, in vivo: 63.2% %) the DBRN. Both the deep and superficial surfaces of the DBRN exhibited an intimate relationship with the vessels of the LoH. A positive correlation between vessel diameter and anthropometric factors was observed. In addition, the muscular branch exhibited a significantly smaller diameter than the RRAab.

Conclusion
Our study detailed the relationship between the LoH and the DBRN and highlighted the high incidence of vessel crossing above the DBRN at the level of the muscular branch. Knowledge of neurovascular crossings is crucial for understanding neurovascular entrapment syndromes and planning interventional procedures to reduce vascular complications.
Immunohistochemical ERG positivity is associated with decreased PSMA expression and lower visibility in corresponding [68Ga]Ga-PSMA-11 PET scans of primary prostate cancer
Authors: Rupp Niels J. , Freiberger Sandra N. , Ferraro Daniela A. , Laudicella Riccardo , Heimer Jakob , Muehlematter Urs J. , Poyet Cédric , Moch Holger , Eberli Daniel , Rüschoff Jan H. , Burger Irene A. 
Published: July 2024

Abstract
Purpose
TMPRSS2:ERG gene fusion negatively regulates PSMA expression in prostate adenocarcinoma (PCa) cell lines. Therefore, immunohistochemical (IHC) ERG expression, a surrogate for an underlying ERG rearrangement, and PSMA expression patterns in radical prostatectomy (RPE) specimens of primary PCa, including corresponding PSMA-PET scans were investigated.

Methods
Two cohorts of RPE samples (total n=148): In cohort #1 (n=62 patients) with available RPE and preoperative [68Ga]Ga-PSMA-11 PET, WHO/ISUP grade groups, IHC-ERG (positive vs. negative) and IHC-PSMA expression (% PSMA-negative tumour area, PSMA%neg) were correlated with the corresponding SUVmax. In the second cohort #2 (n=86 patients) including RPE only, same histopathological parameters were evaluated.

Results
Cohort #1: PCa with IHC-ERG expression (35.5%) showed significantly lower IHC-PSMA expression and lower SUVmax values on the corresponding PET scans. Eight of 9 PCa with negative PSMA-PET scans had IHC-ERG positivity, and confirmed TMPRSS2::ERG rearrangement. In IHC-PSMA positive PCa, IHC-ERG positivity was significantly associated with lower SUVmax values. In cohort #2, findings of higher IHC-PSMA%neg and IHC-ERG expression was confirmed with only 0-10% PSMA%neg tumour areas in IHC-ERG-negative PCa.

Conclusion
IHC-ERG expression is significantly associated with more heterogeneous and lower IHC-PSMA tissue expression in two independent RPE cohorts. There is a strong association of ERG positivity in RPE tissue with lower [68Ga]Ga-PSMA-11 uptake on corresponding PET scans. Results may serve as a base for future biomarker development to enable tumour-tailored, individualized imaging approaches.
Topographic Analysis of the Nipple–Areolar Complex Sensation in Superomedial Pedicle Breast Reduction
Authors: Sonmez Mehmet , Saglam Murat Enes 
Published: July 2024

Abstract

Background
Surgeons meticulously perform breast reductions, while ensuring vascular integrity of the pedicle and Nipple–Areolar complex (NAC) to prevent any complication. It is crucial to remember that loss of sensation is also substantial complication, mainly due to unique characteristic features of the NAC. This study aimed to compare early and long-term sensory results by performing topographic analysis of NAC sensation after superomedial pedicle breast reduction.

Methods
A prospective study was conducted by including nonrandomized female patients who underwent breast reduction surgery with wise pattern excision superomedial pedicle technique between January 2019 and June 2022. Semmes-Weinstein Monofilament (SWM) test performed at preoperatively, 3–6 months and 15–18 months postoperatively. NAC complex was divided into four equal quadrants and nipple: superomedial (SM), inferomedial (IM), inferolateral (IL), superolateral (SL) and Nipple (N). Touch-Test® Sensory Evaluator Chart was used to evaluate sensory results.

Results
None of the patients had any loss of sensation during preoperative SWM test. In postoperative 3–6 months, statistically significant differences were observed between N and SL (p = 0.002), SL and IM (p < 0.05), SM and IM (p < 0.05). In postoperative 15–18 months, there was no difference between the quadrants and nipple (p = 0.07). In early and long-term comparisons of the same quadrants, IL less pronounced than other quadrant comparisons (p = 0.034). A statistical difference was observed in overall NAC score (p < 0.05).

Conclusions
It would be beneficial to inform patients overall NAC sensation in the postoperative may not be as good as preoperative, there might be variations in NAC sensation across different quadrants in early period.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Poleward shifts in commercial fishing vessel distribution over the Bering Sea shelf, 2013–2022
Authors: Vlietstra Lucy S. , Thoenen Jake E. 
Published: July 2024

AbstractRecent studies have documented poleward shifts in heavily targeted fish stocks on the Bering Sea Shelf. This study investigated whether commercial fishing vessels in the region have also shifted their distribution poleward in recent years. We used Vessel Management System data generated between January 1, 2013, and December 31, 2022, to identify regions over the shelf where vessel activity increased (emerging hot spots) and where it decreased (emerging cold spots) during this time period. We hypothesized that emerging hot spots would occur at the northern edge of the vessel operating range, while emerging cold spots would occur at the southern edge. Overall, northward shifts in vessel distribution were most evident during October–February and July–August, when the range of emerging hots spots was centered 204–515 km to the N, NE, or NW of the center of the range of emerging cold spots. The trend was strongest in August, when emerging hot spots were widespread in the Northern Bering Sea. We did not attempt to identify factors driving these distributional shifts, but the timing of shifts did coincide with the busiest fishing seasons over the Bering Sea Shelf and, in part, the open seasons for walleye pollock (Gadus chalcogrammus). If groundfish populations continue to move poleward with climate change, this study may serve as a window into the early stages of a long-term redistribution of commercial fishing effort in the Bering Sea, a region supporting one of the largest fishing industries in the world.
Drivers of the mean biases of the tropical atmospheric circulation in a moist static energy framework
Authors: Fan Chen-Shuo , Dommenget Dietmar 
Published: July 2024

AbstractIn this study, we apply the moist static energy for first baroclinic mode (MSEB) model to examine the drivers of the mean tropical atmospheric circulation biases over oceanic regions. The model diagnoses the vertical motion in an air column of the tropical regions based on net energy heat flux and advection of moisture or heat into the air column in relation to the stability of the air column due to the gradients in moist static energy. Analysis of Coupled Model Intercomparison Project (CMIP) and Atmospheric Model Intercomparison Project (AMIP) simulations helped to identified errors intrinsic to the atmospheric models or errors due to atmosphere–ocean coupling process. Despite some limitations of the MSEB model, our multi-model mean analysis over the entire tropical ocean reveals that the primary drivers of the tropical circulation biases mostly result from intrinsic atmospheric model errors in top of the atmosphere longwave radiation and surface latent heats fluxes, suggesting a link to biases in the hydrological cycle. Oceanic coupling significantly enhanced some of the biases. Biases in the advection of moist static energy also play an important role, while biases in the gross moist stability profiles play only a minor role. Further, we examine the inter-model variations in four main regional large-scale biases (double-ITCZ, Pacific cold tongue, southward shift of ITCZ over the Atlantic, and dipole bias over the Indian Ocean). The analysis suggests that regional bias patterns across general circulation models are primarily driven by coupling errors, except for the bias in the Indian Ocean, which is intrinsic to the atmospheric model but amplified by coupling. Notably, longwave radiation biases at the top of the atmosphere are prevalent among the four bias patterns, as well as biases in moisture advection over the Atlantic. Our results underscore the significant role of net longwave radiation at the top of the atmosphere, an aspect not sufficiently emphasized in previous studies.
Effect of whey protein-derived decapeptide on mood status and blood variables in healthy adults: a randomized, double-blind, placebo-controlled cross-over trial
Authors: Suzuki Katsuya , Okamatsu Yoriko , Uchida Ryo , Sasahara Ikuko , Takeshita Masamichi , Sato Wataru , Kitahara Yoshiro , Murakami Hitoshi 
Published: July 2024

Abstract
Purpose
The importance of maintaining good mental health with overall well-being has recently drawn attention from various fields. Functional peptides found from various protein sources reportedly reduce mental health problems. We found a new decapeptide (AJI-801) from whey proteins, which can possibly improve mood status and increase blood acetyl-L-carnitine (ALC) and fibroblast growth factor 21 (FGF21) levels. In this study, we assessed the effects of a single intake of whey protein hydrolysate containing a high amount of AJI-801 (WPH) on blood variables and mood status.

Methods
A randomized, double-blind, placebo-controlled cross-over trial of two doses of WPH (100 and 500 mg) was conducted. Participants, aged between 20 and 59 years with fatigue were allocated to two groups based on the WPH doses received, and set first test food in each study. The blood ALC and FGF21 levels at baseline and after 60, 120, and 180 min of test food intake were analyzed and the responses to the questionnaire items for mood status were obtained at baseline and after 60 and 180 min of test food intake.

Results
There were no significant differences in the blood ALC and FGF21 levels between the two groups. As mood status, intake of 500-mg WPH (including 2.5-mg AJI-801) showed significant improvement in Depression/Dejection of the Profile of Mood States Questionnaire second edition and visual analog scale score for depression, as compared to the placebo.

Conclusions
Intake of AJI-801 500-mg WPH (including 2.5-mg AJI-801) contributes to the improvement of feeling down in healthy persons with fatigue.

Trial registration
University Hospital Medical Information Network Clinical Trial Registry (UMIN 000046829).
Prediction of bone invasion of oral squamous cell carcinoma using a magnetic resonance imaging-based machine learning model
Authors: Öztürk Elif Meltem Aslan , Ünsal Gürkan , Erişir Ferhat , Orhan Kaan 
Published: July 2024

Abstract
Objectives
Radiomics, a recently developed image-processing technology, holds potential in medical diagnostics. This study aimed to propose a machine-learning (ML) model and evaluate its effectiveness in detecting oral squamous cell carcinoma (OSCC) and predicting bone metastasis using magnetic resonance imaging (MRI).

Materials-methods
MRI radiomic features were extracted and analyzed to identify malignant lesions. A total of 86 patients (44 with benign lesions without bone invasion and 42 with malignant lesions with bone invasion) were included. Data and clinical information were managed using the RadCloud Platform (Huiying Medical Technology Co., Ltd., Beijing, China). The study employed a hand-crafted radiomics model, with the dataset randomly split into training and validation sets in an 8:2 ratio using 815 random seeds.

Results
The results revealed that the ML method support vector machine (SVM) performed best for detecting bone invasion (AUC = 0.999) in the test set. Radiomics tumor features derived from MRI are useful to predicting bone invasion from oral squamous cell carcinoma with high accuracy.

Conclusions
This study introduces an ML model utilizing SVM and radiomics to predict bone invasion in OSCC. Despite the promising results, the small sample size necessitates larger multicenter studies to validate and expand these findings.
Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris
Authors: Vallée Rodolphe , Körpe Dilsah , Vallée Jean-Noël , Tsiropoulos Georgios N. , Gallo Castro Daniela , Mantel Irmela , Pournaras Constantin J. , Ambresin Aude 
Published: July 2024

Abstract
Purpose
To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.

Methods
A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FAAT), start (FAstartLF) and end (FAendLF) of laminar flow, and arterial time (ICGAAT), respectively. OCT angiography VDs were superficial (VDSCP) and deep (VDDCP) RCPs and CC (VDCC) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.

Results
177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VDSCP and VDDCP were significantly inversely correlated with FAAT, FAstartLF and FAendLF likewise VDCC with ICGAAT. Correlations were stronger in patients without CVR than with CVR. CVR, FAAT, FAstartLF and FAendLF were more strongly correlated with VDDCP than VDSCP. FAAT, FAstartLF and FAendLF significantly impacted VDSCP and VDDCP, likewise ICGAAT impacted VDDCP. VDDCP was most strongly impacted by FAAT and FAstartLF.

Conclusion
Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
The Complexity of Finding and Enumerating Optimal Subgraphs to Represent Spatial Correlation
Authors: Enright Jessica , Lee Duncan , Meeks Kitty , Pettersson William , Sylvester John 
Published: July 2024

AbstractUnderstanding spatial correlation is vital in many fields including epidemiology and social science. Lee et al. (Stat Comput 31(4):51, 2021. https://doi.org/10.1007/s11222-021-10025-7) recently demonstrated that improved inference for areal unit count data can be achieved by carrying out modifications to a graph representing spatial correlations; specifically, they delete edges of the planar graph derived from border-sharing between geographic regions in order to maximise a specific objective function. In this paper, we address the computational complexity of the associated graph optimisation problem. We demonstrate that this optimisation problem is NP-hard; we further show intractability for two simpler variants of the problem. We follow these results with two parameterised algorithms that exactly solve the problem. The first is parameterised by both treewidth and maximum degree, while the second is parameterised by the maximum number of edges that can be removed and is also restricted to settings where the input graph has maximum degree three. Both of these algorithms solve not only the decision problem, but also enumerate all solutions with polynomial time precalculation, delay, and postcalculation time in respective restricted settings. For this problem, efficient enumeration allows the uncertainty in the spatial correlation to be utilised in the modelling. The first enumeration algorithm utilises dynamic programming on a tree decomposition of the input graph, and has polynomial time precalculation and linear delay if both the treewidth and maximum degree are bounded. The second algorithm is restricted to problem instances with maximum degree three, as may arise from triangulations of planar surfaces, but can output all solutions with FPT precalculation time and linear delay when the maximum number of edges that can be removed is taken as the parameter.
Integrated operating room planning and scheduling: an ILP-Based off-line approach for emergency responsiveness at a local hospital in Naples
Authors: Boccia Maurizio , Mancuso Andrea , Masone Adriano , Sterle Claudio 
Published: July 2024

AbstractThis paper addresses a real-world Integrated Operating Room Planning and Scheduling (IORPS) problem encountered by a local hospital in Naples, characterized by stringent emergency management constraints, requiring treatment initiation within a 20-minute time-window. We tackle this problem by an original Integer Linear Programming formulation, capable of dealing with different operating room management strategies (open, block and block-modified). Our work differs from conventional cost-focused models by adopting a patient-oriented objective function, aligning with public hospitals obligations. The proposed method has been validated using real-world data provided by the hospital. The performed experimentation demonstrates the efficiency of the approach, capable of determining the optimal solution within an acceptable computation time that aligns with hospital requirements. Moreover, it also highlights the relevance of using our optimization approach to reduce delays in emergency responsiveness. This confirms its practical usage as a substitute for the current manual procedure.
A biased random-key genetic algorithm for the knapsack problem with forfeit sets
Authors: Cerulli Raffaele , D’Ambrosio Ciriaco , Raiconi Andrea 
Published: July 2024

AbstractThis work addresses the Knapsack Problem with Forfeit Sets, a recently introduced variant of the 0/1 Knapsack Problem considering subsets of items associated with contrasting choices. Some penalty costs need to be paid whenever the number of items in the solution belonging to a forfeit set exceeds a predefined allowance threshold. We propose an effective metaheuristic to solve the problem, based on the Biased Random-Key Genetic Algorithm paradigm. An appropriately designed decoder function assigns a feasible solution to each chromosome, and improves it using some additional heuristic procedures. We show experimentally that the algorithm outperforms significantly a previously introduced metaheuristic for the problem.
Evaluation of the effect of adjunctive diode laser application on peri-implant crevicular fluid biomarker levels: a randomized controlled trial
Authors: Erduran Nazan Ece , Guncu Guliz N. , Akman Abdullah C. , Acar Buket , Pinar Asli , Karabulut Erdem , Nohutcu Rahime M. 
Published: July 2024

Abstract
Objectives
To assess both the clinical and immunological effectiveness of diode laser therapy when used as an adjunct to non-surgical mechanical therapy in managing peri-implantitis.

Materials and methods
A cohort of 27 participants, comprising 21 females and 6 males, agreed to take part in this investigation. 37 dental implants with peri-implantitis diagnosis were randomly allocated to either the laser group (n = 19) or the control group (n = 18). Evaluation of peri-implant clinical parameters and collection peri-implant crevicular fluid (PICF) samples occurred at baseline, as well as at 3 and 6-month follow-up intervals. The level of various biomarkers (TWEAK, IL-1β, sclerostin, IL-17, RANKL, OPG and IL-10) within the PICF were quantified using enzyme-linked immunosorbent assay.

Results
Significant time-dependent decreases in clinical and biochemical parameters were detected in both groups compared to the baseline. There were marked differences between the groups in terms of periodontal parameters, except probing depth, and IL-1β, IL-17, sclerostin levels in PICF at 3rd month follow-up. However, no statistically significant difference was detected at 6th month.

Conclusions
Diode laser seems to be a reliable tool as an adjunct for supporting the nonsurgical mechanical treatment during the early stages of peri-implantitis. Furthermore, the findings suggest that IL-17, sclerostin and IL-1β may serve as promising biomarkers for assessing efficacy of peri-implantitis treatment.

Clinical relevance
Based on these outcomes, clinicians may consider the application of adjunctive use of diode laser to non-surgical peri-implantitis treatment to achieve better clinical and immunological improvements than nonsurgical peri-implantitis therapy alone in just early healing period. However, it should be noted that there was no difference between the two methods in the long term.
Relationship between fundus sex index obtained using color fundus parameters and body height or axial length in the Kumejima population
Authors: Yamashita Takehiro , Asaoka Ryo , Iwase Aiko , Sakai Hiroshi , Terasaki Hiroto , Sakamoto Taiji , Araie Makoto 
Published: July 2024

Abstract
Purpose
To investigate the relationship between the fundus sex index obtained from fundus photographs and body height or axial length in the Kumejima population.

Study Design
Prospective cross-sectional observational population study.

Methods
Using color fundus photographs obtained from the Kumejima population, 1,653 healthy right eyes with reliable fundus parameter measurements were included in this study. The tessellation fundus index was calculated as R/(R + G + B) using the mean value of the red-green-blue intensity in the eight locations around the optic disc and foveal region. The optic disc ovality ratio, papillomacular angle, and retinal vessel angle were quantified as previously described. The masculine or feminine fundus was quantified using machine learning (L2 regularized binominal logistic regression and leave one out cross validation), with the range of 0–1 as the predictive value, and defined as the fundus sex index. The relationship between the fundus sex index and body height or axial length was investigated using Spearman’s correlation.

Results
The mean age of the 838 men and 815 women included in this study was 52.8 and 54.0 years, respectively. The correlation coefficient between fundus sex index and body height was − 0.40 (p < 0.001) in all, 0.01 (p = 0.89) in men, and − 0.04 (p = 0.30) in women, and that between fundus sex index and axial length was − 0.23 (p < 0.001) in all, − 0.12 (p < 0.001) in men, and − 0.13 (p < 0.001) in women.

Conclusion
This study shows that a larger number of masculine fundi tend to have longer axial lengths in each sex group. However, sex index was not significantly related with body height either in men or in women.