bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of poor outcome despite recanalization: a multiple regression analysis of the NASA registry
Authors: Linfante Italo , Starosciak Amy K , Walker Gail R , Dabus Guilherme , Castonguay Alicia C , Gupta Rishi , Sun Chung-Huan J , Martin Coleman , Holloway William E , Mueller-Kronast Nils , English Joey D , Malisch Tim W , Marden Franklin A , Bozorgchami Hormozd , Xavier Andrew , Rai Ansaar T , Froehler Michael T , Badruddin Aamir , Nguyen Thanh N , Taqi M Asif , Abraham Michael G , Janardhan Vallabh , Shaltoni Hashem , Novakovic Roberta , Yoo Albert J , Abou-Chebl Alex , Chen Peng R , Britz Gavin W , Kaushal Ritesh , Nanda Ashish , Issa Mohammad A , Nogueira Raul G , Zaidat Osama O 
Published: January 2015

BackgroundMechanical thrombectomy with stent-retrievers results in higher recanalization rates compared with previous devices. Despite successful recanalization rates (Thrombolysis in Cerebral Infarction (TICI) score ≥2b) of 70–83%, good outcomes by 90-day modified Rankin Scale (mRS) score ≤2 are achieved in only 40–55% of patients. We evaluated predictors of poor outcomes (mRS >2) despite successful recanalization (TICI ≥2b) in the North American Solitaire Stent Retriever Acute Stroke (NASA) registry.MethodsLogistic regression was used to evaluate baseline characteristics and recanalization outcomes for association with 90-day mRS score of 0–2 (good outcome) vs 3–6 (poor outcome). Univariate tests were carried out for all factors. A multivariable model was developed based on backwards selection from the factors with at least marginal significance (p≤0.10) on univariate analysis with the retention criterion set at p≤0.05. The model was refit to minimize the number of cases excluded because of missing covariate values; the c-statistic was a measure of predictive power.ResultsOf 354 patients, 256 (72.3%) were recanalized successfully. Based on 234 recanalized patients evaluated for 90-day mRS score, 116 (49.6%) had poor outcomes. Univariate analysis identified an increased risk of poor outcome for age ≥80 years, occlusion site of internal carotid artery (ICA)/basilar artery, National Institute of Health Stroke Scale (NIHSS) score ≥18, history of diabetes mellitus, TICI 2b, use of rescue therapy, not using a balloon-guided catheter or intravenous tissue plasminogen activator (IV t-PA), and >30 min to recanalization (p≤0.05). In multivariable analysis, age ≥80 years, occlusion site ICA/basilar, initial NIHSS score ≥18, diabetes, absence of IV t-PA, ≥3 passes, and use of rescue therapy were significant independent predictors of poor 90-day outcome in a model with good predictive power (c-index=0.80).ConclusionsAge, occlusion site, high NIHSS, diabetes, no IV t-PA, ≥3 passes, and use of rescue therapy are associated with poor 90-day outcome despite successful recanalization.
Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer
Authors: Hofman Paul , Cherfils-Vicini Julien , Bazin Marie , Ilie Marius , Juhel Thierry , Hébuterne Xavier , Gilson Eric , Schmid-Alliana Annie , Boyer Olivier , Adriouch Sahil , Vouret-Craviari Valérie 
Published: January 2015

AbstractColitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of proinflammatory mast cells and cytokines and promote survival of regulatory T cells (Treg) and enteric neurons. In this study, we investigated the effect of P2RX7 blockade in an established mouse model of CAC. Using genetic and pharmacologic tools, we found unexpectedly that while P2RX7 mediated inflammatory responses, it also acted at an early time to suppress CAC development. P2RX7 blockade enhanced proliferation of intestinal epithelial cells and protected them from apoptosis. The proliferative effects of P2RX7 blockade were associated with an increased production of TGFβ1 that was sufficient to stimulate the proliferation of intestinal epithelial cells. Finally, P2RX7 blockade also altered immune cell infiltration and promoted Treg accumulation within lesions of the digestive system. Taken together, our findings reveal an unexpected role for P2RX7 in preventing CAC, suggesting cautions in the use of P2RX7 inhibitors to treat IBD given the possibility of increasing risks CAC as a result. Cancer Res; 75(5); 835–45. ©2015 AACR.
A Coding Single-Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors
Authors: Van Rechem Capucine , Black Joshua C. , Greninger Patricia , Zhao Yang , Donado Carlos , Burrowes Paul d. , Ladd Brendon , Christiani David C. , Benes Cyril H. , Whetstine Johnathan R. 
Published: January 2015

Abstract
SNPs occur within chromatin-modulating factors; however, little is known about how these variants within the coding sequence affect cancer progression or treatment. Therefore, there is a need to establish their biochemical and/or molecular contribution, their use in subclassifying patients, and their impact on therapeutic response. In this report, we demonstrate that coding SNP-A482 within the lysine tridemethylase gene KDM4A/JMJD2A has different allelic frequencies across ethnic populations, associates with differential outcome in patients with non–small cell lung cancer (NSCLC), and promotes KDM4A protein turnover. Using an unbiased drug screen against 87 preclinical and clinical compounds, we demonstrate that homozygous SNP-A482 cells have increased mTOR inhibitor sensitivity. mTOR inhibitors significantly reduce SNP-A482 protein levels, which parallels the increased drug sensitivity observed with KDM4A depletion. Our data emphasize the importance of using variant status as candidate biomarkers and highlight the importance of studying SNPs in chromatin modifiers to achieve better targeted therapy.
Significance: This report documents the first coding SNP within a lysine demethylase that associates with worse outcome in patients with NSCLC. We demonstrate that this coding SNP alters the protein turnover and associates with increased mTOR inhibitor sensitivity, which identifies a candidate biomarker for mTOR inhibitor therapy and a therapeutic target for combination therapy. Cancer Discov; 5(3); 245–54. ©2015 AACR.
See related commentary by Rothbart et al., p. 228
See related article by Van Rechem et al., p. 255
This article is highlighted in the In This Issue feature, p. 213
Can Physicians Identify Inappropriate Nuclear Stress Tests?
Authors: Ye Siqin , Rabbani LeRoy E. , Kelly Christopher R. , Kelly Maureen R. , Lewis Matthew , Paz Yehuda , Peck Clara L. , Rao Shaline , Bokhari Sabahat , Weiner Shepard D. , Einstein Andrew J. 
Published: January 2015

Background—
We sought to determine inter-rater reliability of the 2009 Appropriate Use Criteria for radionuclide imaging and whether physicians at various levels of training can effectively identify nuclear stress tests with inappropriate indications.

Methods and Results—
Four hundred patients were randomly selected from a consecutive cohort of patients undergoing nuclear stress testing at an academic medical center. Raters with different levels of training (including cardiology attending physicians, cardiology fellows, internal medicine hospitalists, and internal medicine interns) classified individual nuclear stress tests using the 2009 Appropriate Use Criteria. Consensus classification by 2 cardiologists was considered the operational gold standard, and sensitivity and specificity of individual raters for identifying inappropriate tests were calculated. Inter-rater reliability of the Appropriate Use Criteria was assessed using Cohen κ statistics for pairs of different raters. The mean age of patients was 61.5 years; 214 (54%) were female. The cardiologists rated 256 (64%) of 400 nuclear stress tests as appropriate, 68 (18%) as uncertain, 55 (14%) as inappropriate; 21 (5%) tests were unable to be classified. Inter-rater reliability for noncardiologist raters was modest (unweighted Cohen κ, 0.51, 95% confidence interval, 0.45–0.55). Sensitivity of individual raters for identifying inappropriate tests ranged from 47% to 82%, while specificity ranged from 85% to 97%.

Conclusions—
Inter-rater reliability for the 2009 Appropriate Use Criteria for radionuclide imaging is modest, and there is considerable variation in the ability of raters at different levels of training to identify inappropriate tests.
Vascular Imaging Abnormalities and Cognition
Authors: Knopman David S. , Griswold Michael E. , Lirette Seth T. , Gottesman Rebecca F. , Kantarci Kejal , Sharrett A. Richey , Jack Clifford R. , Graff-Radford Jonathan , Schneider Andrea L.C. , Windham B. Gwen , Coker Laura H. , Albert Marilyn S. , Mosley Thomas H. 
Published: January 2015

Background and Purpose—
The relationships between cerebrovascular lesions visible on imaging and cognition are complex. We explored the possibility that the cerebral cortical volume mediated these relationships.

Methods—
Total of 1906 nondemented participants (59% women; 25% African–American; mean age, 76.6 years) in the Atherosclerosis Risk in Communities (ARIC) study underwent cognitive assessments, risk factor assessments, and quantitative MRI for white matter hyperintensities (WMH) and infarcts. The Freesurfer imaging analysis pipeline was used to determine regional cerebral volumes. We examined the associations of cognitive domain outcomes with cerebral volumes (hippocampus and separate groups of posterior and frontal cortical regions of interest) and cerebrovascular imaging features (presence of large or small cortical/subcortical infarcts and WMH volume). We performed mediation pathway analyses to assess the hypothesis that hippocampal and cortical volumes mediated the associations between cerebrovascular imaging features and cognition.

Results—
In unmediated analyses, WMH and infarcts were both associated with worse psychomotor speed/executive function. In mediation analyses, WMH and infarct associations on psychomotor speed/executive function were significantly attenuated, but not abolished, by the inclusion of the posterior cortical regions of interest volume in the models, and the infarcts on psychomotor speed/executive function association were attenuated, but not abolished, by inclusion of the frontal cortical regions of interest volume.

Conclusions—
Both WMH and infarcts were associated with cortical volume, and both lesions were also associated with cognitive performance, implying shared pathophysiological mechanisms. Although cross-sectional, our findings suggest that WMH and infarcts could be proxies for clinically covert processes that directly damage cortical regions. Microinfarcts are 1 candidate for such a clinically covert process.
A Study of Multiple Tropopause Structures Caused by Inertia–Gravity Waves in the Antarctic
Authors: Shibuya Ryosuke , Sato Kaoru , Tomikawa Yoshihiro , Tsutsumi Masaki , Sato Toru 
Published: January 2015

Abstract
Multiple tropopauses (MTs) defined by the World Meteorological Organization are frequently detected from autumn to spring at Syowa Station (69.0°S, 39.6°E). The dynamical mechanism of MT events was examined by observations of the first mesosphere–stratosphere–troposphere (MST) radar in the Antarctic, the Program of the Antarctic Syowa MST/Incoherent Scatter (IS) Radar (PANSY), and of radiosondes on 8–11 April 2013.
The MT structure above the first tropopause is composed of strong temperature fluctuations. By a detailed analysis of observed three-dimensional wind and temperature fluctuation components, it is shown that the phase and amplitude relations between these components are consistent with the theoretical characteristics of linear inertia–gravity waves (IGWs).
Numerical simulations were performed by using a nonhydrostatic model. The simulated MT structures and IGW parameters agree well with the observation. In the analysis using the numerical simulation data, it is seen that IGWs were generated around 65°S, 15°E and around 70°S, 15°E, propagated eastward, and reached the region above Syowa Station when the MT event was observed. These IGWs were likely radiated spontaneously from the upper-tropospheric flow around 65°S, 15°E and were forced by strong southerly surface winds over steep topography (70°S, 15°E). The MT occurrence is attributable to strong IGWs and the low mean static stability in the polar winter lower stratosphere.
It is also shown that nonorographic gravity waves associated with the tropopause folding event contribute to 40% of the momentum fluxes, as shown by a gravity wave–resolving general circulation model in the lower stratosphere around 65°S. This result indicates that they are one of the key components for solving the cold-bias problem found in most climate models.
MJO Intensification with Warming in the Superparameterized CESM
Authors: Arnold Nathan P. , Branson Mark , Kuang Zhiming , Randall David A. , Tziperman Eli 
Published: January 2015

Abstract
The Madden–Julian oscillation (MJO) is the dominant mode of tropical intraseasonal variability, characterized by an eastward-propagating envelope of convective anomalies with a 30–70-day time scale. Here, the authors report changes in MJO activity across coupled simulations with a superparameterized version of the NCAR Community Earth System Model. They find that intraseasonal OLR variance nearly doubles between a preindustrial control run and a run with 4×CO2. Intraseasonal precipitation increases at a rate of roughly 10% per 1 K of warming, and MJO events become 20%–30% more frequent. Moist static energy (MSE) budgets of composite MJO events are calculated for each scenario, and changes in budget terms are used to diagnose the physical processes responsible for changes in the MJO with warming. An increasingly positive contribution from vertical advection is identified as the most likely cause of the enhanced MJO activity. A decomposition links the changes in vertical advection to a steepening of the mean MSE profile, which is a robust thermodynamic consequence of warming. Surface latent heat flux anomalies are a significant sink of MJO MSE at 1×CO2, but this damping effect is reduced in the 4×CO2 case. This work has implications for organized tropical variability in past warm climates as well as future global warming scenarios.
Cardiopulmonary bypass changes the plasma proteome in children undergoing tetralogy of Fallot repair
Authors: Hepponstall M , Ignjatovic V , Binos S , Attard C , Karlaftis V , d’Udekem Y , Monagle P , Konstantinov I E 
Published: January 2015

Introduction: Cardiopulmonary bypass (CPB) can be associated with deleterious clinical effects. However, the impact of CPB on inflammatory, immunological and other homeostatic pathways remains poorly understood. We investigated the impact of CPB on the plasma proteome in children undergoing tetralogy of Fallot repair. Methods: Blood samples were taken from 20 children prior to and at the end of CPB and 6h, 12h and 24h after CPB. Plasma was analysed by liquid chromatography-mass spectrometry (LC-MS) in a label-free, untargeted approach. Data were analysed using Genedata software to identify peptides that were differentially expressed (p<0.01 above a false discovery rate). Proteins were identified from peptides that demonstrated differential expression. Results: The proteins that were found to be differentially expressed were haptoglobin isoform 1 preproprotein, isoform 2 of semaphorin-6C, vitamin D-binding protein, inter-alpha-trypsin inhibitor, ceruloplasmin, apolipoprotein B100 and fibrinogen alpha. Conclusion: CPB alters the plasma proteome with differences most apparent at 6h and 12h post CPB. There was a return to baseline with no proteins differentially regulated by 24h.
Primary Partial Humeral Head Resurfacing
Authors: Sweet Stephan J. , Takara Tad , Ho Lance , Tibone James E. 
Published: January 2015

Background: Humeral head defects such as degenerative disease or avascular necrosis are often treated with stemmed hemiarthroplasty or total shoulder arthroplasty. Despite its historical and clinical significance, stemmed humeral head replacement poses inherent technical challenges to placing spherical implants at the anatomically correct head height, version, and neck-shaft angle. Purpose: The aim of this study was to assess humeral head inlay arthroplasty as a joint-preserving alternative that maintains the individual head-neck-shaft anatomy. Humeral head inlay arthroplasty also allows intraoperative surface mapping and placement of a contoured articular component that is matched to the patient’s defect size, location, and individual surface geometry. Study Design: Case series; Level of evidence, 4. Methods: This retrospective case series included 19 patients (20 shoulders), with an average age of 48.9 years (range, 32-58 years; 16 men, 3 women). Preoperative diagnoses were osteoarthritis in 16 shoulders and osteonecrosis in 4 shoulders. Pre- and postoperative evaluations included physical examination, radiographic assessment, the American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form, the Simple Shoulder Test, a pain visual analog scale, and patient satisfaction rating. Results: The mean follow-up period was 32.7 months (range, 17-66 months). The mean American Shoulder and Elbow Surgeons score improved from 24.1 to 78.8, mean Simple Shoulder Test score from 3.95 to 9.3, mean visual analog scale score from 8.2 to 2.1, mean forward flexion from 100° to 129°, and mean external rotation from 23° to 43° ( P < .001 for all). Radiographic follow-up showed no evidence of periprosthetic fracture, component loosening, osteolysis, or device failure. Patient shoulder self-assessment was 90% poor before surgery and improved to 75% good to excellent at last follow-up; 20% of patients self-rated as somewhat good to somewhat poor, and 5% self-rated as poor. Ninety percent of patients were satisfied with the choice of the procedure. Three patients had postoperative complications unrelated to the implants, including a partial rotator cuff tear treated with physical therapy, preexisting glenoid wear treated with arthroscopic debridement and microfracture, and infection complicated by subscapularis rupture requiring several subsequent surgical procedures but with retention of the implant. Conclusion: Humeral head inlay arthroplasty is effective in providing pain relief, functional improvement, and patient satisfaction. Rather than delaying shoulder arthroplasty to end-stage osteoarthritis, humeral head inlay arthroplasty is a promising new direction in primary shoulder arthroplasty for younger and active patients with earlier stage disease.
Knowledge, attitude and practice of standard precautions of infection control by hospital workers in two tertiary hospitals in Nigeria
Authors: Ogoina Dimie , Pondei Kemebradikumo , Adetunji Babatunde , Chima George , Isichei Christian , Gidado Sanusi 
Published: January 2015

Background: Standard precautions are recommended to prevent transmission of infection in hospitals. However, their implementation is dependent on the knowledge and attitudes of healthcare workers (HCW). This study describes the knowledge, attitude and practice (KAP) of standard precautions of infection control among HCW of two tertiary hospitals in Nigeria is described. Methods: A cross-sectional study was undertaken in 2011/2012 among HCW in two tertiary hospitals in Nigeria. Data was collected via a structured self-administered questionnaire assessing core elements of KAP of standard precautions. Percentage KAP scores were calculated and professional differences in median percentage KAP scores were ascertained. Results: A total of 290 HCW participated in the study (76% response rate), including 111 (38.3%) doctors, 147 (50.7%) nurses and 32 (11%) laboratory scientists. Overall median knowledge and attitude scores toward standard precautions were above 90%, but median practice score was 50.8%. The majority of the HCW had poor knowledge of injection safety and complained of inadequate resources to practise standard precautions. House officers, laboratory scientists and junior cadres of nurses had lower knowledge and compliance with standard precautions than more experienced doctors and nurses. Conclusion: Our results suggest generally poor compliance with standard precautions of infection control among HCW in Nigeria. Policies that foster training of HCW in standard precautions and guarantee regular provision of infection control and prevention resources in health facilities are required in Nigeria.
Emotional wellbeing and mental health: an exploration into health promotion in young people and families
Authors: Coverdale Gillian E , Long Andrew F 
Published: January 2015

Aims: Promoting mental health and emotional wellbeing (EWB) in children and young people (YP) is vitally important for their psycho-social development. Critical review of the literature reveals a dearth of research that has explored the perspective of the child, adolescent or adult in this concept, with much research being intervention focused and promoted at crisis level. The current study aims to address this gap in understanding of young persons’ and parents’ perspectives. Method: A small-scale, exploratory qualitative study was conducted with YP, and parents of YP aimed at exploring the meaning of EWB and how it could be promoted. Data were collected via focus groups with 15 YP (aged 18–24 years) and 15 interviews with parents of a different group of YP. Results: Study participants identified key constructs for good EWB as stability, coping ability, happiness, confidence, balance, empathy and being grounded. Feeling comfortable with self, managing and controlling emotions and having the confidence to persevere with challenges were all felt to contribute to a positive sense of EWB. Sources of support were overwhelmingly cited as family and friends, with schools identified as a potentially good environment for supporting and promoting the EWB of pupils. Participants stressed the need for a positive attitude change towards YP, advocating this as promoting a sense of belonging and community citizenship. A lay-informed ‘recipe’ for successful EWB promotion is drawn out, centred on the core goal of raising awareness and understanding of YP’s EWB, in the YP themselves, their parents, schools and the wider community. Conclusions: This research provides key messages for society, policy makers, education and public health and healthcare practitioners for integration into the delivery of services for YP and families that include education on supporting EWB, activities for YP and a multi-agency approach to supporting families within the community.
Manifestations and clinical impact of pediatric inherited thrombophilia
Authors: Klaassen Irene L. M. , van Ommen C. Heleen , Middeldorp Saskia 
Published: January 2015

AbstractThe etiology of pediatric venous thromboembolic disease (VTE) is multifactorial, and in most children, 1 or more clinical risk factors are present. In addition, inherited thrombophilic disorders contribute to the development of pediatric VTE. In this review, the role of inherited thrombophilic disorders in the development of pediatric VTE, as well as the benefits and limitations of thrombophilia testing, will be discussed.