bluuebunny/crossref_metadata_2025_split huggingface dataset:
High sensitive space electric field sensing based on micro fiber interferometer with field force driven gold nanofilm
Authors: Zhu Tao , Zhou Liming , Liu Min , Zhang Jingdong , Shi Leilei 
Published: October 2015

AbstractThe traditional electrical field sensing can be realized by utilizing electro-optic materials or liquid crystals and has limitations of easy breakdown, free assembly and difficult measurement of low-frequency. Here, we propose a new method to realize safe measurement of spatial dynamic electric field by using a micro fiber interferometer integrated with gold nanofilm. The energy of the electric charge received through antenna forms the intrinsic electric field with two micro electrodes, one of which is the 120 nm gold film vibration beam micromachined by femtosecond lasers and integrated with the micro fiber. The change of the intrinsic electric field force due to the spatial electric field will cause the vibration of the film beam. By demodulating the output signal of the micro fiber interferometer, the electric field can be measured. We demonstrate the detectable frequency ranges from tens of Hz to tens of KHz and the minimum electric field intensity is ~200 V/m at 1 KHz. Our electric field measurement technology combining optical fiber interference with gold nanostructures shows the advantages of security, high sensitivity, compact size and multiplexed multi-point and remote detection.
Optical Characterization of Strong UV Luminescence Emitted from the Excitonic Edge of Nickel Oxide Nanotowers
Authors: Ho Ching-Hwa , Kuo Yi-Ming , Chan Ching-Hsiang , Ma Yuan-Ron 
Published: October 2015

AbstractNiO had been claimed to have the potential for application in transparent conducting oxide, electrochromic device for light control and nonvolatile memory device. However, the detailed study of excitonic transition and light-emission property of NiO has rarely been explored to date. In this work, we demonstrate strong exciton-complex emission of high-quality NiO nanotowers grown by hot-filament metal-oxide vapor deposition with photoluminescence as an evaluation tool. Fine and clear emission features coming from the excitonic edge of the NiO are obviously observed in the photoluminescence spectra. A main excitonic emission of ~3.25 eV at 300 K can be decomposed into free exciton, bound excitons and donor-acceptor-pair irradiations at lowered temperatures down to 10 K. The band-edge excitonic structure for the NiO nanocrystals has been evaluated and analyzed by transmission and thermoreflectacne measurements herein. All the experimental results demonstrate the cubic NiO thin-film nanotower is an applicable direct-band-gap material appropriate for UV luminescence and transparent-conducting-oxide applications.
Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation
Authors: Hu Wei , Jain Aakanksha , Gao Yajing , Dozmorov Igor M. , Mandraju Rajakumar , Wakeland Edward K. , Pasare Chandrashekhar 
Published: October 2015

Significance
Successful induction of protective immunity is critically dependent on our ability to design vaccines that can induce dendritic cell (DC) maturation. Here, we investigated the mechanisms by which Toll-like receptor 4 (TLR4) and TLR3 induce DC maturation. We discovered that TLR4 that recognizes LPS from Gram-negative bacteria uses the signaling adaptor Toll–IL-1 receptor domain-containing adaptor inducing IFN-β to induce robust activation of NF-κB and MAP kinases that can directly lead to transcription of genes necessary for DC maturation. However, TLR3 that recognizes viral RNA depends on interferon α/β receptor signaling to induce DC maturation. Discovery of these molecular distinctions by which TLRs that recognize bacteria and viruses induce DC maturation will be beneficial to gaining critical insights into induction of adaptive immunity and for successful design of vaccines.
CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice
Authors: Weber Julia , Öllinger Rupert , Friedrich Mathias , Ehmer Ursula , Barenboim Maxim , Steiger Katja , Heid Irina , Mueller Sebastian , Maresch Roman , Engleitner Thomas , Gross Nina , Geumann Ulf , Fu Beiyuan , Segler Angela , Yuan Detian , Lange Sebastian , Strong Alexander , de la Rosa Jorge , Esposito Irene , Liu Pentao , Cadiñanos Juan , Vassiliou George S. , Schmid Roland M. , Schneider Günter , Unger Kristian , Yang Fengtang , Braren Rickmer , Heikenwälder Mathias , Varela Ignacio , Saur Dieter , Bradley Allan , Rad Roland 
Published: October 2015

Significance
Assigning biological relevance and molecular function to large catalogues of mutated genes in cancer is a major challenge. Likewise, pinpointing drivers among thousands of transcriptionally or epigenetically dysregulated genes within a cancer is complex and limited by the lack of tools for high-throughput functional cancer genomic analyses. We show here for the first time, to our knowledge, application of the CRISPR/Cas9 genome engineering system for simultaneous (multiplexed) mutagenesis of large gene sets in adult mice, allowing high-throughput discovery and validation of cancer genes. We characterized applications of CRISPR/Cas9 multiplexing, resulting tumor phenotypes, and limitations of the methodology. By using defined genetic or environmental predisposing conditions, we also developed, to our knowledge, the first mouse models of CRISPR/Cas9-induced hepatocellular carcinoma and show how multiplexed CRISPR/Cas9 can facilitate functional genomic analyses of hepatobiliary cancers.
Defining the mRNA recognition signature of a bacterial toxin protein
Authors: Schureck Marc A. , Dunkle Jack A. , Maehigashi Tatsuya , Miles Stacey J. , Dunham Christine M. 
Published: October 2015

Significance
Bacteria have a tremendous capacity to rapidly adapt their gene expression profiles and metabolic rates through global regulatory responses. Toxin–antitoxin complexes regulate their own expression under exponential growth but inhibit energy-demanding processes like protein synthesis during stress. A majority of toxins display exquisite endonucleolytic specificity for mRNAs but only in the context of the ribosome. The molecular basis for this selectivity is unclear given their simple microbial RNase architecture. Here, we demonstrate the mechanistic determinants for host inhibition of growth B (HigB) toxin selection of mRNA substrates. Moreover, we propose that ribosome-dependent toxins recognize their mRNA substrates primarily through identification of the third nucleotide of the codon, contrary to how tRNAs and other translation factors also recognize the A site.
ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations
Authors: Chimusa Emile R. , Mbiyavanga Mamana , Mazandu Gaston K. , Mulder Nicola J. 
Published: October 2015

AbstractMotivation: Despite numerous successful Genome-wide Association Studies (GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may miss disease genes with weak genetic effects or strong epistatic effects due to the single-marker testing approach commonly used. GWAS may thus generate false negative or inconclusive results, suggesting the need for novel methods to combine effects of single nucleotide polymorphisms within a gene to increase the likelihood of fully characterizing the susceptibility gene.Results: We developed ancGWAS, an algebraic graph-based centrality measure that accounts for linkage disequilibrium in identifying significant disease sub-networks by integrating the association signal from GWAS data sets into the human protein–protein interaction (PPI) network. We validated ancGWAS using an association study result from a breast cancer data set and the simulation of interactive disease loci in the simulation of a complex admixed population, as well as pathway-based GWAS simulation. This new approach holds promise for deconvoluting the interactions between genes underlying the pathogenesis of complex diseases. Results obtained yield a novel central breast cancer sub-network of the human interactome implicated in the proteoglycan syndecan-mediated signaling events pathway which is known to play a major role in mesenchymal tumor cell proliferation, thus providing further insights into breast cancer pathogenesis.Availability and implementation: The ancGWAS package and documents are available at http://www.cbio.uct.ac.za/~emile/software.htmlContact: emile.chimusa@uct.ac.za, Nicola.Mulder@uct.ac.zaSupplementary information: Supplementary data are available at Bioinformatics online.
Costs per Diagnosis of Acute HIV Infection in Community-based Screening Strategies: A Comparative Analysis of Four Screening Algorithms
Authors: Hoenigl Martin , Graff-Zivin Joshua , Little Susan J. 
Published: October 2015

Abstract
Background.  In nonhealthcare settings, widespread screening for acute human immunodeficiency virus (HIV) infection (AHI) is limited by cost and decision algorithms to better prioritize use of resources. Comparative cost analyses for available strategies are lacking.
Methods.  To determine cost-effectiveness of community-based testing strategies, we evaluated annual costs of 3 algorithms that detect AHI based on HIV nucleic acid amplification testing (EarlyTest algorithm) or on HIV p24 antigen (Ag) detection via Architect (Architect algorithm) or Determine (Determine algorithm) as well as 1 algorithm that relies on HIV antibody testing alone (Antibody algorithm). The cost model used data on men who have sex with men (MSM) undergoing community-based AHI screening in San Diego, California. Incremental cost-effectiveness ratios (ICERs) per diagnosis of AHI were calculated for programs with HIV prevalence rates between 0.1% and 2.9%.
Results.  Among MSM in San Diego, EarlyTest was cost-savings (ie, ICERs per AHI diagnosis less than $13.000) when compared with the 3 other algorithms. Cost analyses relative to regional HIV prevalence showed that EarlyTest was cost-effective (ie, ICERs less than $69.547) for similar populations of MSM with an HIV prevalence rate &gt;0.4%; Architect was the second best alternative for HIV prevalence rates &gt;0.6%.
Conclusions.  Identification of AHI by the dual EarlyTest screening algorithm is likely to be cost-effective not only among at-risk MSM in San Diego but also among similar populations of MSM with HIV prevalence rates &gt;0.4%.
Birth of the Yangtze River: age and tectonic-geomorphic implications
Authors: Zheng Hongbo 
Published: October 2015

AbstractLarge river systems are an integral and essential component of Earth dynamics. The development of large river systems in Asia is closely linked to the evolving topography driven by both near-field and far-field effects of the interplay among Indian, Eurasian and Pacific plates. Plate tectonics together with climatic changes during the Cenozoic is therefore believed to have determined the evolution of Asian large rivers, yet the age of the Yangtze, the largest in Asia, has been strongly debated over a century, with estimates ranging from 40–45 Ma to a more recent initiation postdating 750 ka. In this paper, I attempt to review the competing views about the age of the Yangtze, and evaluate the estimated pre-Miocene birth of the river based on the provenance of the fluvial sediments from the lower reaches. I further present new geological evidence from the upper stream in southeastern Tibetan Plateau to show the existence of a possible southward paleo-Jinshajiang during the Paleogene, and exploit when and how it might deviated eastward to give birth to the modern Yangtze River. I propose that the present Yangtze River system formed in response to the continental-scale gradient driven by uplifting Tibetan Plateau and regional extension throughout eastern China, synchronous with surface uplift in southeastern Tibet and strengthening of Asian summer monsoon.
Clean-energy development in China
Authors: Qiu Jane 
Published: October 2015

Abstract
In June, China announced its 2030 target to cut its greenhouse-gas emissions per unit of gross domestic product by 60%–65% from 2005 levels. To achieve the goal, it would increase the share of non-fossil fuels as part of its primary energy consumption to 20% by 2030 and aim to peak emissions around the same time. As world's largest carbon emitter, the announcement is widely hailed not only as a strong impetus for the UN climate talks, which are convened in Paris this month, but a solution to the country's unprecedented choking pollution.
In a forum chaired by National Science Review's executive associate editor Mu-ming Poo, four panelists from diverse backgrounds discuss how clean-energy development could help China to fight against air pollution and meet its 2030 target, what sorts of policies need to be in place, and what the main challenges are.
Analysis of Serial Radiographs of the Foot to Determine Normative Values for the Growth of the First Metatarsal to Guide Hemiepiphysiodesis for Immature Hallux Valgus
Authors: Greene Janelle D. , Nicholson Allen D. , Sanders James O. , Cooperman Daniel R. , Liu Raymond W. 
Published: October 2015

Background:
Hallux valgus deformity in the immature patient can be difficult to manage, as osteotomy can result in recurrence with additional growth. Lateral hemiepiphysiodesis of the first metatarsal offers a promising alternative, by permitting gradual correction of the intermetatarsal angle with growth. An important limitation of this approach is the lack of normative tables of first metatarsal growth to guide timing of intervention.

Methods:
First metatarsal lengths were measured from anteroposterior foot radiographs of children. For females, 95 patients totaling 894 radiographs were used ranging from 6 months to 18 years of age. For males, 122 patients totaling 1018 radiographs were measured ranging from 8 months to 19.5 years of age. All patients with image series including a closed proximal metatarsal physis were sorted into an older group, with multipliers generated by setting last image to a multiplier of 1. Patients with serial imaging not inclusive of a closed physis were classified as a younger group, with multipliers based off of the multiplier at age 7 from the older group. First metatarsal multiplier values were then compared with published multiplier values for the overall foot.

Results:
For both females and males, the multipliers followed a logarithmic curve versus age, with R
2 values of 0.921 and 0.888, respectively. Comparison of the first metatarsal multiplier values with previously studied multiplier values of the entire foot showed high correlation with ICC=0.955 for females and ICC=0.969 for males.

Conclusions:
The pattern of growth of the first metatarsal follows a logarithmic regression curve. These normative tables allow for clinical prediction of first metatarsal remaining growth based on age and sex, and in turn guide timing of hemiepiphysiodesis for the surgical correction of hallux valgus deformity.

Clinical Relevance:
The normative tables generated in this study can be used for the calculation of hemiepiphysiodesis and the timing of intervention. Future clinical correlation studies will be important.
Semiquantitation of Axonal Injury in Traumatically Damaged Brains Using Color Deconvolution
Authors: Dutschke Jeffrey K. , Finnie John W. , Manavis Jim , Anderson Robert W.G. 
Published: October 2015

Introduction:
In traumatic brain injury biomechanics, macroscale biomechanical events need to be correlated with microscale neuropathologic changes and improved quantitation of microscopic axonal injury is an essential component of lesion evaluation.

Objectives:
To develop a novel technique for automatically identifying injured amyloid precursor protein immunopositive axons and aggregating these observations over a macroscopic brain dissection.

Methods:
A color deconvolution method was adapted into Matlab to identify clusters of pixels with colors typical of amyloid precursor protein positive tissue from large-scale brain dissection.

Results:
The methodology is demonstrated in the brain of a sheep subjected to a controlled cortical indentation.

Conclusions:
The technique will be of interest to pathologists and bioengineers seeking to quantitate brain injury over macroscales.
Supervisory support and organizational citizenship behavior
Authors: Yadav Mohit , Rangnekar Santosh 
Published: October 2015

Purpose– The purpose of this paper is to investigate the role of participation in decision making (PDM) and job satisfaction (JS) in supervisory support and the organizational citizenship behavior (OCB) relationship.Design/methodology/approach– Two models with PDM and JS as mediators were tested on the supervisory support-OCB relationship. A sample of 198 Indian business executives was collected exclusively through management development programs (MDPs). To test the hypotheses in this research, correlation and regression analysis were both used. Furthermore, to test the mediation level, Baron and Kenny’s (1986) method was deployed.Findings– All variables in the study were found to be significantly related to each other. Both models were supported by the findings, suggesting that supervisory support promotes both PDM and JS. This, in turn, increases OCB in employees. PDM was found to be the better mediator within the relationship. Implications of these results are also discussed.Research limitations/implications– Self-reported responses could give biased results; peers should also have been included in the data gathering. Variables in the study cannot be analyzed in isolation. Hence control variables need to be included to arrive at more accurate and informative results.Practical implications– The findings contribute to better understanding of the supervisory support/OCB relationship, and the ways of improving this through PDM and JS. As an outcome of this research, organizations should aim to support, empower and involve their employees. Satisfying their needs will lead to them becoming more effective citizens within the organization. Businesses can harness the potential of OCB in employees by giving them a “voice” in decision making and by encouraging them to share ideas.Originality/value– The use of PDM and JS in this relationship is unprecedented. The establishment of PDM as a better mediator of the relationship is also unique. The study draws its strength from a multi-organizational sample and the use of MDPs to provide unbiased responses. Since the study is based on an Indian sample, it also adds to the growing literature of OCB from non-western economies.
China’s shadow banking sector: beneficial or harmful to economic growth?
Authors: Barth James R. , Li Tong , Shi Wen , Xu Pei 
Published: October 2015

Purpose
– The purpose of this paper is to examine recent developments pertaining to China’s shadow banking sector. Shadow banking has the potential not only to be a beneficial contributor to continued economic growth, but also to contribute to systematic instability if not properly monitored and regulated. An assessment is made in this paper as to whether shadow banking is beneficial or harmful to China’s economic growth.

Design/methodology/approach
– The authors start with providing an overview of shadow banking from a global perspective, with information on its recent growth and importance in selected countries. The authors then focus directly on China’s shadow banking sector, with information on the various entities and activities that comprise the sector. Specifically, the authors examine the interconnections between shadow banking and regular banking in China and the growth in shadow banking to overall economic growth, the growth in the money supply and the growth in commercial bank assets.

Findings
– Despite the wide range in the estimates, the trend in the size of shadow banking in China has been upward over the examined period. There are significant interconnections between the shadow banking sector and the commercial banking sector. Low deposit rate and high reserve requirement ratios have been the major factors driving its growth. Shadow banking has been a contributor, along with money growth, to economic growth.

Practical implications
– The authors argue that shadow banking may prove useful by diversifying China’s financial sector and providing greater investments and savings opportunities to consumers and businesses throughout the country, if the risks of shadow banking are adequately monitored and controlled.

Originality/value
– To the authors’ knowledge, this paper is among the few to systematically evaluate the influence of shadow banking on China’s economic growth.
“I’m going to prove you wrong”
Authors: Vega Desireé , Moore III James L. , Miranda Antoinette H. 
Published: October 2015

Purpose– This study aims to explore perceptions of discrimination among ten African American youths as part of a larger qualitative investigation.Design/methodology/approach– The qualitative methodology utilized the “Prove them Wrong Syndrome” as a theoretical framework. Individual interviews and biographical questionnaires were the primary sources of data collection.Findings– Four major themes emerged from data analysis: perceived discrimination from others, perceived discrimination from members of one’s own racial group, responses to perceived discrimination and buffers against perceived discrimination.Practical implications– Implications for educators including teachers, school psychologists and school counselors are discussed.Originality/value– This paper attempted to fill the void in the literature, as it explored the perceptions of discrimination among African American youth, their responses to perceived discrimination and the identification of buffers to compensate for negative experiences with discrimination. Prove them Wrong Syndrome emerged as a major finding in this study as a response to perceived discrimination; nonetheless, it should be further evaluated, as limited research has been conducted in this area. Teachers must be aware of issues students of color may experience at school such as discrimination and how this can harm them emotionally and academically. Moreover, school psychologists and school counselors should be utilized as mental health service providers to combat the potentially negative outcomes of discrimination.
Looking back
Authors: Hardy III Jay H. , Gibson Carter , Buckley M. Ronald 
Published: October 2015

Purpose
– The purpose of this paper is to reflect on the early direction and maturation of the Journal of Management History (JOMH), evaluate the lasting impact of this primary work and identify implications of findings of this paper for future developments in the study of management history. This article provides a review of the first five years (1995-1999) of the JOMH.

Design/methodology/approach
– Articles published in the JOMH between the years of 1995 and 1999 were reviewed, and unifying thematic categories were developed. Two independent raters, then, sorted the articles into their respective categories. After agreement was established, general trends in the JOMH’s early direction and focus were considered. Lasting impact was evaluated using citations in Google Scholar by category and year. Similarities among the most cited articles during this period are discussed.

Findings
– The early years of the JOMH were characterized by shifts in contributions from various management and public administration perspectives, a transition from an early emphasis on historical individuals to a broader focus on topics and ideas and a balance between describing historical accounts (i.e. retelling or recording historical events and individuals) and historical analysis (i.e. considering the influence of historical events and ideas on future events and modern perspectives). The most influential early contributions to the JOMH were articles that focused on the histories of specific management concepts, an approach that is still important and relevant today.

Originality/value
– This review provides insights into the development and maturation of the JOMH following its formation.