bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of psychosis-related clinical profiles in children with autism spectrum disorders using latent class analysis
Authors: Kyriakopoulos Marinos , Stringaris Argyris , Manolesou Sofia , Radobuljac Maja Drobnič , Jacobs Brian , Reichenberg Avi , Stahl Daniel , Simonoff Emily , Frangou Sophia 
Published: June 2014

Abstract
In children with autism spectrum disorders (ASD), high rates of idiosyncratic fears and anxiety reactions and thought disorder are thought to increase the risk of psychosis. The critical next step is to identify whether combinations of these symptoms can be used to categorise individual patients into ASD subclasses, and to test their relevance to psychosis. All patients with ASD (n = 84) admitted to a specialist national inpatient unit from 2003 to 2012 were rated for the presence or absence of impairment in affective regulation and anxiety (peculiar phobias, panic episodes, explosive reactions to anxiety), social deficits (social disinterest, avoidance or withdrawal and abnormal attachment) and thought disorder (disorganised or illogical thinking, bizarre fantasies, overvalued or delusional ideas). Latent class analysis of individual symptoms was conducted to identify ASD classes. External validation of these classes was performed using as a criterion the presence of hallucinations. Latent class analysis identified two distinct classes. Bizarre fears and anxiety reactions and thought disorder symptoms differentiated ASD patients into those with psychotic features (ASD-P: 51 %) and those without (ASD-NonP: 49 %). Hallucinations were present in 26 % of the ASD-P class but only 2.4 % of the ASD-NonP. Both the ASD-P and the ASD-NonP class benefited from inpatient treatment although inpatient stay was prolonged in the ASD-P class. This study provides the first empirically derived classification of ASD in relation to psychosis based on three underlying symptom dimensions, anxiety, social deficits and thought disorder. These results can be further developed by testing the reproducibility and prognostic value of the identified classes.
Expanded newborn screening in New South Wales: missed cases
Authors: Estrella Jane , Wilcken Bridget , Carpenter Kevin , Bhattacharya Kaustuv , Tchan Michel , Wiley Veronica 
Published: June 2014

AbstractThere have been few reports of cases missed by expanded newborn screening. Tandem mass spectrometry was introduced in New South Wales, Australia in 1998 to screen for selected disorders of amino acid, organic acid and fatty acid metabolism. Of 1,500,000 babies screened by 2012, 1:2700 were diagnosed with a target disorder. Fifteen affected babies were missed by testing, and presented clinically or in family studies. In three cases (cobalamin C defect, very‐long‐chain acyl‐CoA dehydrogenase deficiency and glutaric aciduria type 1), this led to modification of analyte cut‐off values or protocols during the first 3 years. Two patients with intermittent MSUD, two with β‐ketothiolase deficiency, two with citrin deficiency, two siblings with arginosuccinic aciduria, two siblings with homocystinuria, and one with cobalamin C defect had analyte values and ratios below the action limits which could not have been detected without unacceptable false‐positive rates. A laboratory interpretation error led to missing one case of cobalamin C defect. Reference ranges, regularly reviewed, were not altered. For citrin deficiency, while relevant metabolites are detectable by tandem mass spectrometry, our cut‐off values do not specifically screen for that disorder. Most of the missed cases are doing well and with no acute presentations although eight of 15 are likely to have been somewhat adversely affected by a late diagnosis. Analyte ratio and cut‐off value optimisations are important, but for some disorders occasional missed cases may have to be tolerated to maintain an acceptable specificity, and avoid harm from screening.
The differential relation of childhood maltreatment to stress sensitization in adolescent and young adult depression
Authors: La Rocque Cherie L. , Harkness Kate L. , Bagby R. Michael 
Published: June 2014

ABSTRACTChildhood maltreatment has been shown to have a stronger etiological relation to depression onset in adolescence than in adulthood. We propose that a maltreatment history may more strongly sensitize individuals to the depressogenic effects of proximal stressful life events in adolescence compared to adulthood. In an amalgamated sample of 176 unipolar depressed adolescents (age 12–17) and emerging adults (age 18–29), we examined the moderating role of age group on the relation of childhood maltreatment to sensitization to stressors that occurred just prior to episode onset. Among adolescents, but not among adults, those with a maltreatment history reported a lower severity level of life events prior to episode onset than reported by those without such a history. Further, this relation was specific to emotional abuse, and not physical or sexual abuse. We suggest that the pathological mechanisms associated with translating childhood maltreatment to depression may differ across developmental periods.
Expressions of p16 and p27 in urothelial carcinoma and their prognostic value
Authors: Yang Ching‐Hsiu , Wu Chun‐Chieh , Chen Wan‐Tzu , Chai Chee‐Yin , Yang Sheau‐Fang 
Published: June 2014

AbstractExpressions of human p16 and p27 were tested for correlations with clinicopathologic features of urothelial carcinoma (UC). Tissue microarrays (TMA) constructed from paraffin‐embedded specimens from 78 patients with UC were analyzed by immunohistochemical staining. In 49 of the 78 tumors (63%), high p16 expression was associated with absence of tumor invasiveness and low‐grade carcinoma (p = 0.003 and p = 0.046, respectively). The p27 expression was high in 33 of the 78 tumors (42%) and showed a significant negative association with invasiveness, carcinoma grade, and tumor size (p = 0.016, p = 0.046, and p = 0.014, respectively). Kaplan–Meier analysis indicated that patients with high p27 levels had longer than average overall survival (p = 0.021). This study demonstrates that p16 and p27 are prognostic indicators of tumor stage and grade in UC and that they provide clinicians with the ancillary information needed for selecting suitable therapeutic strategies.
O-MINIMALISM
Authors: SCHOUTENS HANS 
Published: June 2014

AbstractThis paper is devoted to o-minimalism, the study of the first-order properties of o-minimal structures. The main protagonists are the pseudo-o-minimal structures, that is to say, the models of the theory of all o-minimal L-structures, but we start with a more in-depth analysis of the well-known fragment DCTC (Definable Completeness/Type Completeness), and show how it already admits many of the properties of o-minimal structures: dimension theory, monotonicity, Hardy structures, and quasi-cell decomposition, provided one replaces finiteness by discreteness in all of these. Failure of cell decomposition leads to the related notion of a eukaryote structure, and we give a criterium for a pseudo-o-minimal structure to be eukaryote.To any pseudo-o-minimal structure, we can associate its Grothendieck ring, which in the non-o-minimal case is a nontrivial invariant. To study this invariant, we identify a third o-minimalistic property, the Discrete Pigeonhole Principle, which in turn allows us to define discretely valued Euler characteristics. As an application, we study certain analytic subsets, called Taylor sets.
Larval and female footprints as feeding deterrent cues for immature stages of two congeneric ladybird predators (Coleoptera: Coccinellidae)
Authors: Kumar B. , Mishra G. , Omkar  
Published: June 2014

AbstractIn the present study predation parameters, i.e. consumption rate, conversion efficiency and growth rate, and total developmental duration of immature stages of two congeneric ladybirds,Coccinella septempunctata(L.) andCoccinella transversalisF., have been evaluated in presence of conspecific and heterospecific fourth instar larval and adult female tracks. We hypothesized that the semiochemicals within larval/adult female tracks might act as foraging/feeding deterrent pheromones (FDPs) and would reduce the predation parameters; and would prolong total developmental duration of ladybird predators. Results of the study positively affirmed our hypothesis. The deterrence in prey consumption and reduction in conversion efficiency and growth rate was density dependent with species-specific variations. Consumption rate, conversion efficiency, and growth rate of larval instars decreased and the total developmental duration of immature stages increased when exposed to an increasing density of zero, two, three, and four conspecific/heterospecific larval/adult female tracks. Between ladybird species,C. septempunctatahad higher consumption rate, growth rate, and total developmental durations, whereas conversion efficiency was higher inC. transversalis. Despite the presence of semiochemical tracks as foraging barriers, early instars showed higher conversion efficiencies and growth rates, whereas fourth instars had highest consumption rate in all experimental treatments. The present study, therefore, suggests that semiochemical tracks significantly reduce the predation potential and prolong developmental duration of conspecifics and heterospecifics. They, thus behave as FDP.
Diapause incidence and duration in the pest mango blossom gall midge,Procontarinia mangiferae(Felt), on Reunion Island
Authors: Amouroux P. , Normand F. , Delatte H. , Roques A. , Nibouche S. 
Published: June 2014

AbstractThe mango blossom gall midge,Procontarinia mangiferae, is a multivoltine species that induces galls in inflorescences and leaves of the mango tree,Mangifera indica. In subtropical Reunion Island, populations ofP. mangiferaeare observed all-year round, but the pattern and the role of dormancy in their life cycle have never been documented. We performed field and laboratory experiments using more than 15,000 larvae. We demonstrated that a larval diapause may affect a part of the midge population, regardless of the season. The total duration of the diapause varied from 6 weeks to more than 1 year. One year of field monitoring showed that the highest incidence of diapause was observed in larvae collected during the summer from mango leaves, where it affected approximately one-third of the individuals. This facultative diapause allows the permanent presence ofP. mangiferaein the orchards. By recording diapause duration during 22 weeks under controlled conditions, we showed that high temperatures (26 °C) increased diapause duration and extended the range of the dates of diapause emergence, whereas cool temperatures (20 °C) shortened diapause duration and shortened the range of the dates of emergence from diapause. A temperature decrease from 26 to 20 °C triggered the emergence of diapausing individuals. These mechanisms ensure the synchronization of the emergence of diapausing individuals with the appearance of mango inflorescences, which is also induced by cool winter temperatures.
Pro-Nicene prosopology and the church in Augustine's preaching on John 3:13
Authors: Ployd Adam 
Published: June 2014

AbstractJohn 3:13 presents a grammatical and theological problem for Augustine. If the only one who ascends to heaven is the one who descended, namely Christ, then what becomes of the Christian life of ascent? To unpack Augustine's solution to this problem, this article explores his use of John 3:13 in his anti-Donatist sermons of 406–7. Here Augustine uses the grammatical method of prosopological exegesis both to identify and to solve the problem of Christ's solo ascent. Prosopology asks of a text, ‘Who is speaking? To whom is he speaking? And about whom is he speaking?’ in order to parse the sometimes ambiguouspersonaewithin a dramatic scene. Through this method, Augustine affirms that Christ is indeed speaking about himself alone, but the reflexive subject of Christ includes the church who is his body. The Christian life of ascent to God requires that we become participants in the subject of Christ's ‘I’. Building on the work of ‘New Canon’ Augustine scholarship, I argue that this use of John 3:13 to espouse the unity of the church in the body of Christ is founded upon a pro-Nicene understanding of the revelatory and epistemological role of the Son. The ability of Christ fully to reveal the Father is a central tenet of Latin pro-Nicene refutations of homoian christologies, and this revelation of the Father's Word through Christ's incarnation is accomplished in our union with that Word through his body. Based on this pro-Nicene affirmation of epistemological salvation through Christ, Augustine then uses John 3:13 to condemn the Donatists for damning themselves by separating from the body of Christ. The oneness of the ecclesial body of Christ is predicated upon the oneness of Christ himself because it is into his complex subject that we are incorporated. Separation from that unity is separation from the singular grammatical subject who ascends as Christ to the Father. Thus, Augustine's grammatical practice of prosopological exegesis to solve the problem of John 3:13 connects the pro-Nicene affirmation of Christ's revelation of the Father to an anti-Donatist defence of the necessary unity of the church. This should encourage us to consider further the ways in which pro-Nicene principles help to shape Augustine's vision of the church.
On the orthodoxy of Jonathan Edwards
Authors: Crisp Oliver 
Published: June 2014

AbstractJonathan Edwards had some strange ideas. He was an idealist like Berkeley. He denied that the world persists through time, claiming that it is continuously created out of nothing by God moment-by-moment. He also denied creaturely causal action in his doctrine of occasionalism. Moreover, he thought that the world is the necessary output of the essential creativity of the deity, embracing the idea that this is the best possible world. Often these views are not reported in popular accounts of his work, though they are widely known in the scholarly community. But is his position theologically orthodox? This article argues that he is faced with anEdwardsian Dilemma:Either he must admit that his theology proper implies that God is not metaphysically simple, or he must embrace pantheism. Neither horn seems particularly attractive. Of the two, the second seems less appealing than the first. Nevertheless, it looks as if the logic of his position presses in this direction. His idealism and Neoplatonic conception of God's necessary emanation of the world imply panentheism. When coupled with his doctrine of divine simplicity, it looks as if his position could be pressed in a pantheist direction. However, if he opts for the first horn, he must deny the doctrine of divine simplicity, which he endorses in a range of works. If God is simple, then it looks as if all his ideas imply one another and the divine essence. Yet the world is an emanation of divine ideas, which Edwards believes God constantly ‘communicates’. Suppose with Edwards that the world is an ordered series of divine ideas. Then it looks as if they must imply each other and the divine nature as well, given divine simplicity. Clearly this is intolerable, as far as orthodoxy goes. One option is for the Edwardsian to revise divine simplicity, so that God is merely a metaphysical simple like a soul. Then he may have distinct states and properties. However, in addition to this revision one would need to amend Edwards’ occasionalism because it provides an apparently insuperable problem of evil for his metaphysics. Thus, revising the first horn involves more than a little tinkering with the deep structures of Edwards’ thought. However, I argue that this is what the Edwardsian must do if she wants to hold onto a broadly orthodox Edwardsian view on these matters.
A promise is a promise: God's covenantal relationship with animals
Authors: Hiuser Kris , Barton Matthew 
Published: June 2014

AbstractThe place of the nonhuman animal within Christian doctrine is a topic of increasing interest, as more theologians seek to describe where nonhuman animals fit on the theological stage. One area where there seems great potential, yet which has been relatively untouched, is God's covenantal relationship with nonhuman animals as described within the Bible. This article is an attempt to use the idea of God's covenantal relationship with nonhuman creatures to build a case for understanding them as creatures of value, with a corresponding human calling to treat them in ways suitable to their value. This case is made in two sections. In the first, the fact that God covenants with nonhuman animals, and calls humans into covenant with them, will be shown through examining Genesis 9 and Hosea 2. Given such a reality, what it means to be involved in a covenant will be examined, and ultimately two main implications will be put forward. First, that nonhuman animals are worthy of covenantal care and protection, and second that humans have a calling to exist in a covenantal relationship with them. Following this, this article then turns to its second section, where it examines the ways in which the Christian tradition has (or has not) intentionally chosen to live out such a covenantal theology with nonhuman animals. The doctrines of two contemporary Christian denominations (Anglican and Roman Catholic) as described in significant denominational documents are examined, as are two groups from these respective traditions which choose to pay close attention to the welfare of nonhuman animals to address the manner in which the covenantal relationship shared between human and nonhuman animals is recognised and understood in the church today. While the groups focused on nonhuman animal welfare continually call for the church to recognise the value of all creatures as described in the covenantal relationship all animals are involved in, their respective denominations often fail to live out such ethical implications. In light of the significance of the covenantal relationship, it is suggested that the church is called to engage in deeper acts of moral discernment on matters of animal ethics.
Developmental changes in the early child lexicon in Mandarin Chinese
Authors: HAO MEILING , LIU YOUYI , SHU HUA , XING AILING , JIANG YING , LI PING 
Published: June 2014

ABSTRACTIn this paper we report a large-scale developmental study of early productive vocabulary acquisition by 928 Chinese-speaking children aged between 1;0 and 2;6, using the Early Vocabulary Inventory for Mandarin Chinese (Hao, Shu, Xing & Li, 2008). The results show that: (i) social words, especially words for people, are the predominant type of words in Chinese-speaking children's earliest productive vocabulary; (ii) overall, Chinese-speaking children's vocabulary contains greater proportions of nouns than other word categories, especially at the earliest vocabulary stage; and (iii) verbs tend to appear earlier for Chinese-speaking children as compared with English-speaking children at the same levels of vocabulary development. In addition, our study has identified the underlying variables that influence the age of acquisition of words, specifically, the interplay between the conceptual (imageability) and linguistic properties (word frequency, word length, and grammatical category) that jointly shape the development of Mandarin-speaking children's early vocabulary.
Spatio-temporal clustering of hand, foot and mouth disease at the county level in Sichuan province, China, 2008–2013
Authors: LIU L. , ZHAO X. , YIN F. , LV Q. 
Published: June 2014

SUMMARYChina has recently experienced a marked increase in the incidence of hand, foot and mouth disease (HFMD). Effective spatio-temporal monitoring of HFMD incidence is important for successful implementation of control and prevention measures. This study monitored county-level HFMD reported incidence rates for Sichuan province, China by examining spatio-temporal patterns. County-level data on HFMD daily cases between January 2008 and December 2013 were obtained from the China Information System for Disease Control and Prevention. We first conducted purely temporal and purely spatial descriptive analyses to characterize the distribution patterns of HFMD. Then, the global Moran'sIstatistic and space–time scan statistic were used to detect the spatial autocorrelation and identify the high-risk clusters in each year, respectively. A total of 212267 HFMD cases were reported in Sichuan province during the study period (annual average incidence 43·65/100000), and the incidence seasonal peak was between April and July. Relatively high incidence rates appeared in the northeastern–southwestern belt. HFMD had positive spatial autocorrelation at the county level with global Moran'sIincreasing from 0·27 to 0·52 (P < 0·001). Spatio-temporal cluster analysis detected six most-likely clusters and several secondary clusters from 2008 to 2013. The centres of the six most-likely clusters were all located in the provincial capital city Chengdu. Chengdu and its neighbouring cities had always been spatio-temporal clusters, which indicated the need for further intensive space–time surveillance. Allocating more resources to these areas at suitable times might help to reduce HFMD incidence more effectively.
The Construction of a Masculine Warrior Ideal in the Italian Narratives of the First World War, 1915–68
Authors: MONDINI MARCO 
Published: June 2014

AbstractIn Italy from the 1920s to the post-1945 period, soldiers’ autobiographical writings represented the ‘theatre of memory’ to the new generations: they handed down the meaning of intervention, mobilisation and sacrifice. They are characterised by two shared elements. The first one is the recurring theme of self-sacrifice. At the core of all war stories there is the experience of fighting and death; this is a liminal experience that fixes one's relation to war. The second one is the author's profile. The narrator of the ‘warrior phenomenon’ is almost invariably a young reserve officer, which means, in the majority of cases, a twenty-year old middle-class man, often a high-school graduate or a university student. The most powerful leitmotiv running through the mixed array of texts and genres that make up the ‘narrative field’ of the Great War is the metaphor of the military community as a ‘family’. Young officers, typically former students from a city background and interventionists at heart, consistently referred to their admission to the ‘family’ of soldiers at war as a life-changing transition: they had left behind their ordinary bourgeois existence, comfortable and safe (and therefore ‘unmanly’), to step into a new world, a dimension of death and suffering, but also comradeship and solidarity. Pure and unshakeable, genuine and disinterested, brotherhood in arms is so deeply felt that it borders on the intensity of a homoerotic relationship, although the latter is rarely made explicit.
Professionalism in the Final Solution: French Railway Workers and the Jewish Deportations, 1942–4
Authors: BROCH LUDIVINE 
Published: June 2014

AbstractWhy did railway workers never sabotage the deportation trains? This article examines the role of French railway workers in the Holocaust by historicising the concept of railway professionalism. It argues that the actions and behaviour of French railwaymen, whether blue-collar, white-collar or Jewish, were rooted in long-standing professional identities and values which were difficult to shift, even during the occupation. So whereas the professionalism of Holocaust bureaucrat perpetrators is often demonised, this article points to its socio-cultural importance and offers a more nuanced interpretation of ‘perpetrators’ in the Holocaust.