bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential therapeutic strategies for MASH: from preclinical to clinical development
Authors: Xie Zhifu , Li Yufeng , Cheng Long , Huang Yidan , Rao Wanglin , Shi Honglu , Li Jingya 
Published: July 2024

AbstractCurrent treatment paradigms for metabolic dysfunction-associated steatohepatitis (MASH) are based primarily on dietary restrictions and the use of existing drugs, including anti-diabetic and anti-obesity medications. Given the limited number of approved drugs specifically for MASH, recent efforts have focused on promising strategies that specifically target hepatic lipid metabolism, inflammation, fibrosis, or a combination of these processes. In this review, we examined the pathophysiology underlying the development of MASH in relation to recent advances in effective MASH therapy. Particularly, we analyzed the effects of lipogenesis inhibitors, nuclear receptor agonists, glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonists, fibroblast growth factor mimetics, and combinatorial therapeutic approaches. We summarize these targets along with their preclinical and clinical candidates with the ultimate goal of optimizing the therapeutic prospects for MASH.
Delayed Diagnosis of a Ligamentous Lisfranc Injury on a Bomber Task Force Member
Authors: Anderson Kevin D , Harper Hollan , Ayers Sarah K 
Published: July 2024

ABSTRACT
The tarsometatarsal joint, or Lisfranc joint, is an extremely important anatomical structure and injury to it has been shown to cause long-term disabling ramifications. With a wide spectrum of injury involvement, from fracture dislocations to sprains, it is important to establish a diagnosis early to guide management. Although the more extreme higher energy fracture dislocations are more widely studied, there remains a paucity of literature on lower energy purely ligamentous injuries, especially among military service members.1 The deployed setting provides an extra layer of complexity in determining a musculoskeletal injury etiology for the provider, especially in resource-limited areas. When a high level of suspicion for Lisfranc injury exists based upon clinical presentation and in the setting of negative X-rays, more prudence should be placed on additional workup. This will guide decision-making for possible expedited stateside return for the patient and better odds of follow-up care. The following case demonstrates a unique scenario of an undiagnosed, purely ligamentous Lisfranc tear in a 23-year-old woman in a deployed environment with late presentation to an orthopedic surgeon stateside. Furthermore, emphasis is placed on factors that led to her delayed diagnosis and how advocating for advanced imaging modalities up-front can expedite care.
The Role of Student Coping Strategies on Success in the Command Actions Course: A Special Operations Selection Course of the Brazilian Army
Authors: Tolentino Filipe de Carvalho , Ferreira Daniele Bittencourt 
Published: July 2024

ABSTRACT

Introduction
Army Command Action units in Brazil are recognized for their operational effectiveness, operating in hostile scenarios. However, these operations are extremely stressful, requiring specific stress-coping skills. The objective of this study was to identify the profile of stress-coping strategies of military personnel enrolled in the Command Actions Course (CAC) and their relationship with completion of the course.

Materials and Methods
A prospective cohort study was carried out with 87 military personnel from the CAC class of 2022. Data were collected on personal characteristics, coping strategies, and stress levels, among other variables. Specific instruments were used to assess coping (Brief-COPE), stress (DASS-21), social support (MOSS), and sociodemographic variables (own instrument) to evaluate the relationship between coping with stress and course completion. Descriptive analyses were performed (central tendency and dispersion measures), and overall survival analysis was performed using the log-rank test for comparison (P &lt; .05). Cox regression was used for multiple analyses considering a statistical significance of 5%.

Results
A total of 31% of the participants completed the course. The profile of graduates is mainly composed of young people with higher education, single status, and White. Certain coping strategies such as Active Coping (hazard ratio (HR) = 1.48; 95% CI, 1.25-1.75) as well as high stress levels (HR = 1.07; 95% CI, 1.02-1.11) were associated with disengagement, while the Humor-based coping strategy reduced the chance of disengagement by 15% (HR = 0.85; 95% CI, 0.74-0.98).

Conclusions
This study highlights the importance of investigation using coping strategies in the military context as a useful tool in coping with stress in the CAC.
Associations Between PTSD Features and Firearm Ownership and Storage: Results From the PRImary Care Screening Methods (PRISM) Study
Authors: Bauder Christina Rose , Rooney Emily A , Hay Jarrod M , Long Cameron M , Bryan Craig J 
Published: July 2024

ABSTRACT

Introduction
Veterans and active duty service members are significantly more likely to die by suicide using firearms compared to the general population. Not-secure firearm storage (e.g., keeping guns loaded/in an unlocked location) is associated with greater risk for suicide and a third of veteran firearm owners store at least 1 personal firearm unsecured. Veterans and active duty service members are also significantly more likely to be diagnosed with posttraumatic stress disorder (PTSD) than the general population. Symptoms of PTSD are divided into 4 criteria: reexperiencing, avoidance, negative affect, and hyperarousal. Research has suggested that endorsement of hyperarousal symptoms is positively associated with unsecure firearm storage and that avoidance symptoms might be negatively associated with unsecure storage practices. The present study examined the relationship between self-reported firearm ownership and storage practices among each item from the Primary Care PTSD Screening for DSM-IV-TR (PC-PTSD-IV) to explore associations between PTSD features and firearm ownership and storage.

Materials and Methods
Participants were recruited from primary care clinics across 5 military installations in the United States as part of a larger study (Mage = 45.4, SD = 16.9). Among participants (n = 2,685), most of our sample identified as male (51.3%) and white (67.3%) with 61.6% currently serving in the military, 16.8% retirees, and 21.6% family members. PTSD symptoms were assessed using the PC-PTSD-IV and a quarter met the clinical threshold for PTSD. Binomial and multinomial logistic regression analyses were used.

Results
Among completed responses, 989 (38.1%) people reported owning guns; among gun owners, 386 (39.0%) reported that they were loaded, and 352 (35.6%) reported they were loaded and unlocked. Endorsement of specific items on the PC-PTSD-IV, including those specific to hyperarousal and avoidance, was not significantly associated with storing firearms loaded and/or in nonsecure locations when controlling for military service. Non-responses to items around firearm storage practices were significantly associated with those individuals meeting the clinical threshold for PTSD according to the PC-PTSD-IV and participants currently serving had higher odds of storing at least 1 personal firearm loaded and both loaded and unlocked.

Conclusions
Results from our study highlight similarities and departures from the previous literature on the connection between PTSD and non-secure firearm storage practices. Further research may examine (1) the relation between PTSD symptoms and firearm storage between active duty service members, retirees, and family members and (2) whether non-response to items regarding firearm ownership is systematic.
Histoplasmosis in non-immunosuppressed patients from an endemic area in Northeastern Brazil
Authors: Leitão Terezinha do Menino Jesus Silva , Rodrigues Nina Brunet Saraiva , Farias Luís Arthur Brasil Gadelha , Henn Guilherme Alves de Lima , Mota Rosa Salani , Costa Rafael de Sousa , Damasceno Lisandra Serra 
Published: July 2024

Abstract
Differently from immunocompromised patients, very little information is available in the literature regarding the clinical presentation, epidemiology, and outcomes of histoplasmosis in non-immunosuppressed individuals living in endemic areas. This retrospective case series study was carried out by reviewing the medical records of non-immunocompromised patients with histoplasmosis, residents in a hyperendemic area in northeastern Brazil, between 2011 and 2022. Thirty HIV-negative patients were identified with histoplasmosis, and 19 cases met the inclusion criteria: three had acute, five subacute and one chronic pulmonary forms; two with mediastinal picture and eight had disseminated disease (two with severe symptoms). The median age of our sample was 32.7 years old [interquartile range: 24–45]. Most of the patients were male (male-to-female ratio = 15:4) and resided in the state capital (n = 9). The majority had a previous history of exposure to well-known risk factors for Histoplasma infection. Pulmonary nodules were observed in all subacute form, two patients (acute and subacute forms) were initially treated empirically for pulmonary tuberculosis; one death was registered in the subacute form. The chronic pulmonary form of histoplasmosis was diagnosed in one patient only after the symptoms persisted despite specific treatment. The primary clinical manifestations of the moderate form of DH were enlarged lymph nodes, with histopathology being the main diagnostic method. The cases were detected as isolated occurrences and not as an outbreak, suggesting that exposure to Histoplasma can be more widespread than presumed. Despite the self-limiting nature of the disease, death can occur even in previously heathy patients.
Determining the viewing angle from TeV light curve of GRB 221009A
Authors: Zhou Lin , Zou Yuan-Chuan 
Published: July 2024

ABSTRACT
Gamma-ray bursts (GRBs) are among the most powerful explosive events in the Universe. LHAASO recently observed the most luminous one: GRB 221009A, and unveiled its TeV light curve. The light curve exhibits a distinct jet break at around 670 s, enabling the derivation of the viewing angle based on the smoothness of the jet break. We constructed two models with or without considering the high-latitude radiation, where the viewing angle was treated as a free parameter, to fit the TeV light curve. The viewing angles obtained were 9.4 $\times 10^{-4}$ and 5.9 $\times 10^{-3}$ rad, respectively. These values closely resemble an on-axis scenario, given the opening angle is 1.4 $\times 10^{-2}$ rad.
Isochrone fitting of the open cluster M67 in the era of Gaia and improved model physics
Authors: Reyes Claudia , Stello Dennis , Hon Marc , Trampedach Regner , Sandquist Eric , Pinsonneault Marc H 
Published: July 2024

ABSTRACT
The Gaia mission has provided highly accurate observations that have significantly reduced the scatter in the colour–magnitude diagrams of open clusters. As a result of the improved isochrone sequence of the open cluster M67, we have created new stellar models that avoid commonly used simplifications in 1D stellar modelling, such as mass-independent core overshooting and a constant mixing length parameter. This has enabled us to deliver a precise isochrone specifically designed for M67, available for download. We follow a commonly used qualitative approach to adjust the input physics to match the well-defined colour–magnitude sequence, and we test the model-predicted masses against a known eclipsing binary system at the main sequence turnoff of the cluster. Despite using improvements in photometry and stellar physics we cannot match the masses of both binary components with the same theoretical isochrone. A $\chi ^{2}$-based isochrone fitting approach using our preferred input physics results in a cluster age of $3.95^{+ 0.16}_{- 0.15}$ Gyr.
Kinematic morphology of low-mass galaxies in IllustrisTNG
Authors: Zeng Guangquan , Wang Lan , Gao Liang , Yang Hang 
Published: July 2024

ABSTRACT
The origin of diverse kinematic morphologies observed in low-mass galaxies is unclear. In this study, we investigate the kinematic morphologies of central galaxies with stellar mass $10^{8.5-9.0}{\rm M}_{\odot }$ at $z=0$ in the TNG50-1 cosmological simulation. The majority of the low-mass galaxies in TNG50-1 are dispersion-dominated, consistent with observations. By tracing the evolutionary histories of simulated low-mass galaxies, we find that while most stars form in rotating cold gas discs, the orientation of the star-forming discs relative to the galaxies may evolve with cosmic time. If the cold gas disc remains aligning with the galaxy during its evolution, stars formed at different times share the same rotational direction, leading to a rotation-dominated system. On the contrary, frequent misalignment of cold gas disc would result in a dispersion-dominated system. In addition, we also find that the two-body scattering can have a non-negligible numerical heating effect on the simulated galaxy morphology, especially at central regions of galaxies and for relatively low-mass galaxies. By comparing results of simulations with different resolutions, our results suggest that the simulated morphology of galaxies is roughly reliable when their number of stellar particles exceeds about $10^{4}$, and bulge morphology of galaxies can not be resolved robustly at the resolution level of TNG50-1.
A study of two FRBs with low polarization fractions localized with the MeerTRAP transient buffer system
Authors: Rajwade K M , Driessen L N , Barr E D , Pastor-Marazuela I , Berezina M , Jankowski F , Muller A , Kahinga L , Stappers B W , Bezuidenhout M C , Caleb M , Deller A , Fong W , Gordon A , Kramer M , Malenta M , Morello V , Prochaska J X , Sanidas S , Surnis M , Tejos N , Wagner S 
Published: July 2024

ABSTRACT
Localization of fast radio bursts (FRBs) to arcsecond and subarcsecond precision maximizes their potential as cosmological probes. To that end, FRB detection instruments are deploying triggered complex-voltage capture systems to localize FRBs, identify their host galaxy, and measure a redshift. Here, we report the discovery and localization of two FRBs (20220717A and 20220905A) that were captured by the transient buffer system deployed by the MeerTRAP instrument at the MeerKAT telescope in South Africa. We were able to localize the FRBs to precision of $\sim$1 arcsecond that allowed us to unambiguously identify the host galaxy for FRB 20220717A (posterior probability $\sim$0.97). FRB 20220905A lies in a crowded region of the sky with a tentative identification of a host galaxy but the faintness and the difficulty in obtaining an optical spectrum preclude a conclusive association. The bursts show low linear polarization fractions (10–17 per cent) that conform to the large diversity in the polarization fraction observed in apparently non-repeating FRBs akin to single pulses from neutron stars. We also show that the host galaxy of FRB 20220717A contributes roughly 15 per cent of the total dispersion measure (DM), indicating that it is located in a plasma-rich part of the host galaxy which can explain the large rotation measure. The scattering in FRB 20220717A can be mostly attributed to the host galaxy and the intervening medium and is consistent with what is seen in the wider FRB population.
Eccentricity dynamics of wide binaries – II. The effect of stellar encounters and constraints on formation channels
Authors: Hamilton Chris , Modak Shaunak 
Published: July 2024

ABSTRACT
Gaia wide stellar binaries (separations $\sim 10^3{\!-\!}10^{4.5}$ au) are observed to have a superthermal eccentricity distribution function (DF), well-fit by $P(e) \propto e^\alpha$ with $\alpha \sim 1.2$. In a previous paper, we proved that this DF cannot have been produced by Galactic tidal torques starting from any realistic DF that was not already superthermal. Here, we consider the other major dynamical effect on wide binaries: encounters with passing stars. We derive and solve the Fokker–Planck equation governing the evolution of binaries in semimajor axis and eccentricity under many weak, impulsive, penetrative stellar encounters. We show analytically that these encounters drive the eccentricity DF towards thermal on the same time-scale as they drive the semimajor axes a towards disruption, $t_\mathrm{dis}\sim 4\, \mathrm{Gyr}\, (a/10^4\, \mathrm{AU})^{-1}$. We conclude that the observed superthermal DF must derive from an even more superthermal (i.e. higher $\alpha$) birth distribution. This requirement places strong constraints on the dominant binary formation channels. A testable prediction of our theory is that $\alpha$ should be a monotonically decreasing function of binary age.
The influence of baryons on low-mass haloes
Authors: Zheng Haonan , Bose Sownak , Frenk Carlos S , Gao Liang , Jenkins Adrian , Liao Shihong , Springel Volker , Wang Jie , White Simon D M 
Published: July 2024

ABSTRACT
The Voids-within-Voids-within-Voids project used dark-matter-only (DMO) simulations to study the abundance and structure of dark matter (DM) haloes over the full mass range populated in the standard Lambda cold dark matter cosmology. Here, we explore how baryonic effects modify these results for $z=0$ halo masses in the range $10^4$–$10^7~\mathrm{M_\odot }$, below the threshold for galaxy formation. Our main study focuses on three simulations from identical initial conditions at $z=127$, one following DMO, one including non-radiative gas, and one additionally including the baryonic physics relevant in this halo mass range (cooling and photoheating). In the non-radiative simulation, above $10^{5.5}~\mathrm{M_\odot }$, halo abundance and internal structure are very similar to the DMO simulation, and the baryon to DM ratio is everywhere close to the cosmic value. At lower mass, this ratio drops and haloes are less concentrated and less massive in the non-radiative case. Test simulations at higher resolution show this to be mainly a resolution effect; the expected drop in baryon content due to residual pressure effects only becomes substantial for $z=0$ haloes below ${\sim}10^{2.7}~\mathrm{M_\odot }$. However, gas is heated by reionization at $z=6$ in our ‘full physics’ run, and this results in almost complete expulsion of gas from all haloes in our simulated mass range. This suppresses the halo mass function by ${\sim}30{{\ \rm per\ cent}}$, lowers halo concentration, and consequently weakens the DM annihilation signal by ${\sim}40{-}60{{\ \rm per\ cent}}$.
Nietzsche’s Genealogical Perfectionism
Authors: Lorenzini Daniele 
Published: July 2024

ABSTRACT
I argue that Nietzsche’s Genealogy of Morality can be productively read as perfectionist in Emerson’s sense. After reconstructing the debate on Nietzsche’s perfectionism, I problematize the literature’s almost exclusive focus on Schopenhauer as Educator at the expense of the Genealogy, which has caused scholars to construe Nietzsche’s perfectionism in merely individualistic terms. By contrast, I show that the Genealogy can be interpreted as a perfectionist endeavor, at the heart of which lies the first-person plural: the “we.” I thereby emphasize the relevance of “we-making” for a novel reading of Nietzsche’s perfectionism—what I call his genealogical perfectionism. I conclude that the analysis of the genealogical dimension of Nietzsche’s perfectionism provides us with much-needed resources to construe it in nonindividualistic terms.
Unlocking precision gene therapy: harnessing AAV tropism with nanobody swapping at capsid hotspots
Authors: Hoffmann Mareike D , Gallant Joseph P , LeBeau Aaron M , Schmidt Daniel 
Published: July 2024

Abstract
Adeno-associated virus (AAV) has been remarkably successful in the clinic, but its broad tropism is a practical limitation of precision gene therapy. A promising path to engineer AAV tropism is the addition of binding domains to the AAV capsid that recognize cell surface markers present on a targeted cell type. We have recently identified two previously unexplored capsid regions near the 2/5-fold wall and 5-fold pore of the AAV capsid that are amenable to insertion of larger protein domains, including nanobodies. Here, we demonstrate that these hotspots facilitate AAV tropism switching through simple nanobody replacement without extensive optimization in both VP1 and VP2. Our data suggest that engineering VP2 is the preferred path for maintaining both virus production yield and infectivity. We demonstrate highly specific targeting of human cancer cells expressing fibroblast activating protein (FAP). Furthermore, we found that the combination of FAP nanobody insertion plus ablation of the heparin binding domain can reduce off-target infection to a minimum, while maintaining a strong infection of FAP receptor-positive cells. Taken together, our study shows that nanobody swapping at multiple capsid locations is a viable strategy for nanobody-directed cell-specific AAV targeting.
Exploring complex and integrated information during sleep
Authors: Onoda Keiichi , Akama Hiroyuki 
Published: July 2024

Abstract
The Integrated Information Theory is a theoretical framework that aims to elucidate the nature of consciousness by postulating that it emerges from the integration of information within a system, and that the degree of consciousness depends on the extent of information integration within the system. When consciousness is lost, the core complex of consciousness proposed by the Integrated Information Theory disintegrates, and Φ measures, which reflect the level of integrated information, are expected to diminish. This study examined the predictions of the Integrated Information Theory using the global brain network acquired via functional magnetic resonance imaging during various tasks and sleep. We discovered that the complex located within the frontoparietal network remained constant regardless of task content, while the regional distribution of the complex collapsed in the initial stages of sleep. Furthermore, Φ measures decreased as sleep progressed under limited analysis conditions. These findings align with predictions made by the Integrated Information Theory and support its postulates.
Emerging innovations in electrically powered artificial muscle fibers
Authors: Lang Tianhong , Yang Lixue , Yang Shiju , Sheng Nan , Zhang Yiyao , Song Xiaofei , Guo Yang , Fang Shaoli , Mu Jiuke , Baughman Ray H 
Published: July 2024

ABSTRACT
This review systematically explores the inherent structural advantages of fiber over conventional film or bulk forms for artificial muscles, emphasizing their enhanced mechanical properties and actuation, scalability, and design flexibility. Distinctive merits of electrically powered artificial muscle fiber actuation mechanisms, including electrothermal, electrochemical and dielectric actuation, are highlighted, particularly for their operational efficiency, precise control capabilities, miniaturizability and seamless integration with electronic components. A comprehensive overview of significant research driving performance enhancements in artificial muscle fibers through materials and structural innovations is provided, alongside a discussion of the diverse design methodologies that have emerged in this field. A detailed comparative assessment evaluates the performance metrics, advantages and manufacturing complexities of each actuation mechanism, underscoring their suitability for various applications. Concluding with a strategic outlook, the review identifies key challenges and proposes targeted research directions to advance and refine artificial muscle fiber technologies.