bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Separation of Benign and Malignant Mesothelial Proliferations
Authors: Churg Andrew , Galateau-Salle Francoise 
Published: September 2012

Context.—The separation of benign from malignant mesothelial proliferations is crucial to patient management but is often a difficult problem for the pathologist.Objective.—To review the pathologic features that allow separation of benign from malignant mesothelioma proliferations, with an emphasis on new findings.Data Sources.—Literature review and experience of the authors.Conclusions.—Invasion is still the most reliable indicator of malignancy. The distribution and amount of proliferating mesothelial cells are important in separating benignity from malignancy, and keratin stains can be valuable because they highlight the distribution of mesothelial cells. Hematoxylin-eosin examination remains the gold standard, and the role of immunochemistry is extremely controversial; we believe that at present there is no reliable immunohistochemical marker of malignancy in this setting. Mesothelioma in situ is a diagnosis that currently cannot be accurately made by any type of histologic examination. Desmoplastic mesotheliomas are characterized by downward growth of keratin-positive spindled cells between S100-positive fat cells; some cases of organizing pleuritis can mimic involvement of fat, but these fatlike spaces are really S100-negative artifacts aligned parallel to the pleural surface. Fluorescence in situ hybridization on tissue sections to look for homozygous p16 gene deletions is occasionally useful, but many mesotheliomas do not show homozygous p16 deletions. Equivocal biopsy specimens should be diagnosed as atypical mesothelial hyperplasia and another biopsy requested if the clinicians believe the process is malignant.
La route des paniers
Authors: Mundler Patrick , Rumpus Lucas 
Published: September 2012

Vus comme participant au développement durable dans ses trois dimensions – sociale, économique et environnementale –, les circuits alimentaires de proximité font l’objet d’un intérêt croissant de la part des consommateurs, des producteurs agricoles et des collectivités territoriales. Plusieurs travaux récents remettent pourtant en cause l’une des vertus supposées des circuits de proximité : celle de leur contribution à une moindre dépense énergétique pour leur distribution. Schématiquement, ces recherches montrent que le moyen de transport importe plus que les kilomètres parcourus et que la distribution alimentaire de masse en circuits longs, du fait d’économies d’échelles, présente de meilleurs bilans énergétiques que les circuits de proximité. Sur la base de mesures effectuées pour divers modes de distribution de paniers de fruits et légumes, nous montrons dans cet article que la performance de ces circuits courts, en termes d’efficacité énergétique, est comparable à celle de circuits plus longs. Les circuits de proximité étudiés se traduisent en effet par des efforts d’organisation locaux ou à l’échelle de petits réseaux territoriaux dont ne peuvent rendre compte les études reposant sur des moyennes qui ignorent les pratiques spatiales concrètes des acteurs, qu’il s’agisse des agriculteurs ou des consommateurs.
Double Cubane Cluster Protein and Its Reductase
Authors: Jeoung Jae‐Hun , Dobbek Holger 
Published: June 2024

Abstract
Chemically demanding reductions in biology may be achieved by coupling electron transfer to ATP hydrolysis. To achieve a unidirectional electron transfer against a redox‐potential gradient, the double‐cubane cluster‐containing protein (DCCP) forms a complex with an ATP‐dependent reductase, which couples ATP hydrolysis with electron transfer from its [4Fe4S] cluster to the active site of DCCP. DCCP has been named after its cofactor, containing two cubane‐type [4Fe4S] clusters linked by a μ‐sulfido ligand. The double‐cubane cluster is coordinated by six conserved cysteine residues, with both [4Fe4S] subclusters experiencing different environments. While the physiological substrate of DCCP is unknown, it catalyzes the nonphysiological reduction of acetylene, azide, and hydrazine. DCCP and its reductase are homologous to atypical dehydratases and class‐I benzoyl‐CoA reductases and share mechanistic analogies with nitrogenases and reductive activators of corrinoid proteins.
Unfavorable Outcomes Associated With Glucocorticoid Use in Current Standard‐of‐Care Management of Systemic Lupus Erythematosus in Canada
Authors: Touma Zahi , Kayaniyil Sheena , Parackal Anna , Bonilla Denisse , Su Jiandong , Qian Christina , Miller Sally D. , Johnston Adam , Gahn James , Hille Erik D. , Ohsfeldt Robert , Chandran Shelly 
Published: June 2024

ObjectiveOur objective was to describe the administration of glucocorticoids (GCs) and characterize its association with organ damage in a longitudinal systemic lupus erythematosus (SLE) cohort over a time period spanning the introduction of biologics in Canada.MethodsA retrospective observational study was conducted using data from a large SLE cohort in Canada, including adults without lupus nephritis or central nervous system lupus. Patients were observed from time of entry into the cohort to the last available clinic visit (up to December 31, 2020), with a minimum of 24 months of follow‐up. Demographic and clinical characteristics, including average disease activity, treatment administration, and prevalence of organ damage, were examined. Organ damage was stratified by GC administration.ResultsA total of 1,255 patients were included. The mean follow‐up duration was 10.5 (SD 8.6) years. One hundred eighty‐two (15%) patients had organ damage at baseline. More than 80% of patients were prescribed GCs over the follow‐up period, almost all patients had long‐term GC treatment, and only 5% of patients took any biologics. Organ damage was more frequent in patients with a higher average GC dose and greater years of GC exposure.ConclusionIn this large cohort of patients with SLE, the majority of patients continue to rely on GC for SLE symptom management, with limited administration of biologics. GC administration was correlated with increased irreversible organ damage. Access to novel GC‐sparing treatment options is critical to improve long‐term outcomes for patients with SLE, especially given the continued reliance on GC despite the introduction of biologics.
A Supramolecular Organic Framework‐Mediated Electrochemical Strategy Achieves Highly Selective and Continuous Uranium Extraction
Authors: Wang Chaoyi , Xu Meiyun , Wang Wenwen , Hua Daoben 
Published: June 2024

AbstractThe integration of selectivity and electron transfer ability remains a primary challenge in developing electrode materials for uranium electroextraction. Herein, a phenanthroline‐based supramolecular organic framework (MPSOF) is elaborately constructed as a pioneering cathode material through the hydrogen bond‐driven self‐assembly of melamine and 1,10‐phenanthroline 2,9‐dicarboxylic acid (PDA) for selective and continuous electrochemical uranium extraction (EUE). PDA moieties selectively capture UO22+, while the hydrogen bond‐supporting frameworks provide an efficient electron transfer channel for the redox of UO22+. These structural features enable the rapid formation and spontaneous shedding of uranium precipitate from MPSOF, allowing for the regeneration of the selective adsorption sites. As a result, MPSOF‐mediated EUE exhibits a high extraction capacity of 7311 mg U g−1 at a low voltage of −3.5 V but does not reach equilibrium. Cyclic EUE is employed to uranium extraction from simulated high‐salt radioactive effluents and attains high selectivity for uranium. The electroextraction mechanism is confirmed, wherein uranium species transform into (UO2)O2·4H2O. This work not only provides an efficient electrode material for uranium electroextraction, but also presents a novel electrochemical strategy for separation and adsorption of other radionuclides and contaminant ions.
Decoupling Substitution Effects from Point Defects in Layered Ni‐Rich Oxide Cathode Materials for Lithium‐Ion Batteries
Authors: Karger Leonhard , Korneychuk Svetlana , Sicolo Sabrina , Li Hang , van den Bergh Wessel , Zhang Ruizhuo , Indris Sylvio , Kondrakov Aleksandr , Janek Jürgen , Brezesinski Torsten 
Published: June 2024

AbstractNi‐rich LiNixCoyMnzO2 cathode materials offer high practical capacities and good rate capability, but are notorious for being unstable at high state of charge. Here, a series of such layered oxides with nickel contents ranging from 88 to 100 mol% is fabricated by sodium‐to‐lithium ion exchange, yielding materials devoid of substitutional defects. Examining the initial charge/discharge cycle reveals effects that are specifically caused by transition‐metal substitution, which would otherwise be obscured by changes in lithium‐site defect concentration. Lowering the nickel content helps to stabilize the high‐voltage regime, while simultaneously negatively affecting lithium diffusion. Operando X‐ray diffraction indicates mitigation of volume variation during cycling and transition toward solid‐solution behavior with sufficiently high cobalt and manganese contents, thus providing an explanation for the increased stability. The interplay between transition‐metal substitution, kinetic hindrance, and solid‐solution behavior may be a result of local inhomogeneities due to lithium‐vacancy pinning, which is further elucidated through density functional theory calculations. Overall, this work sheds new light on the effects of manganese and cobalt incorporation into the transition‐metal layer and their conjunction with defects.
An Ultrasensitive Perovskite Single‐Model Plasmonic Strain Sensor Based on Piezoelectric Effect
Authors: Li Meili , Lu Junfeng , Wan Peng , Jiang Mingming , Mo Yepei , Pan Caofeng 
Published: June 2024

AbstractInterest in flexible photonics has been motivated by the development of artificial smart skins. In particular, coupling of photonics and mechanics can offer opportunities to realize ultrasensitive strain sensor, however, low‐cost fabrication of flexible sensing device with desired photonic functionality remains a challenge. Hereby, the study reports an ultrasensitive strain‐gauge sensor based on the poly(ethylenenaphthalate (PEN))/monocrystal Au/MgF2/CsPbBr3 nanorod/Al2O3/polyacrylonitrile (in short P/mAu/M/CPB@Al2O3@PAN), which are sensitive to nanoscale structure alterations of PEN substrate via the stress response of the single‐mode laser based on the piezoelectric‐effect. Wherein a low‐threshold single‐mode lasing (Pth ≈ 170 nJ cm−2) is achieved through coating Al2O3 on the CsPbBr3 nanorod, producing the higher quality factor (Q ≈ 1637) to guarantee a much higher sensitivity in sensing application. Reversible spectral regulating of ≈3 nm in single‐mode‐lasing wavelength, with a subnanometre scale resolution <0.4 nm and the wavelength sensitivity (Sλ) as high as 160 nm RIU−1, is validated in response to applied strain ranging from −1.31% to 1.31%. This work not only represents essential progress in construction of ultrasensitive and cost‐effective flexible photonic sensor, but also lays the foundation for the potential application in smart photonic skins.
Enhanced Long‐Term Performance of Sulfides in Oxygen Evolution Reaction by Sulfate Ion‐Assisted Strategy
Authors: Chen Qiming , Zhang Qicheng , Chen Bin , Zhang Jinghan , Peng Wenchao , Li Yang , Fan Xiaobin 
Published: June 2024

AbstractTransition metal sulfides (TMS) exhibit significant promise as non‐noble‐metal electrocatalysts for the oxygen evolution reaction (OER) in alkaline environments, notwithstanding their susceptibility to long‐term instability due to the gradual leaching of surface‐reconstructed sulfate ions (SO42−). In this study, a sulfate ion‐assisted strategy is proposed to stabilize the surface‐reconstructed SO42− of FeNiS2. The findings reveal that SO42− experiences considerable loss in KOH due to the infinite concentration gradient of SO42− on the surface. Conversely, in K2SO4/KOH, this strategy mitigates rapid leaching and preserves the predominant surface‐reconstructed SO42−, thereby enhancing stability in both accelerated degradation (5000 cycles) and long‐term (≥120 h) tests, with ≈95% current density retained. Furthermore, the optimal concentration of SO42− proves to be crucial, as supported by both experimental and theoretical results. This approach offers insights into bolstering the long‐term OER stability of TMS and similar compounds, thereby advancing the prospects for widespread application in electrocatalytic water splitting.
Reversible Glass‐Crystal Transition in a New Type of 2D Metal Halide Perovskites
Authors: Wang Wei , Liu Cheng‐Dong , Fan Chang‐Chun , Zhang Wen 
Published: June 2024

AbstractCrystalline metal halide perovskites (MHPs) have ushered in remarkable advancements across diverse fields, including materials, electronics, and photonics. While the advantages of crystallinity are well‐established, the ability to transition to a glassy state with unique properties presents unprecedented opportunities to expand the structure‐property relationship and broaden the application scope for 2D MHPs. Up until now, the exploration of amorphous analogs for MHPs is confined to high‐pressure conditions, limiting in‐depth studies and practical applications. In this context, a new type of 2D MHPs is synthesized by incorporating halogen substituted organic cations, resulting in a remarkable combination of low melting temperature and inhibited crystallization. This new type of 2D MHPs can be effectively melt‐quenched into a glassy state except for (DMIEA)3Pb2I7 (DMIEA = N, N‐dimethyl iodoethylammonium) counterpart. Analysis of the crystallization activation energy for (DMIPA)4Pb3I10 (DMIPA = N, N‐dimethyl iodopropylammonium) reveals a low crystallization activation energy of 60.7 ± 4.0 kJ mol−1, which indicates a fast glass‐crystal transition. The type of atypical 2D MHP showcases facile and reversible switching between glassy and crystalline states and opens up novel possibilities for applications, such as nonvolatile memory, optical communication, and neuromorphic computing.
Simultaneously Improving Stretchability and Efficiency of Flexible Organic Solar Cells by Incorporating a Copolymer Interlayer in Active Layer
Authors: Zhang Dongling , Wu Yue , Yan Cenqi , Cheng Pei , Zhang Guangye , Yang Hang , Cui Chaohua 
Published: June 2024

AbstractMechanical stretchability is a vital criterion for the wearable application of organic solar cells (OSCs), while the excessive rigidity of fused‐ring small molecular acceptors make the photovoltaic film hard to meet the stretchable requirements. Herein, an effective strategy is developed to construct an intrinsically stretchable active layer by inserting copolymer PM6‐b‐PYSe as an interlayer between layer‐by‐layer processed D18 and BTP‐eC9. The copolymer interlayer shunts the penetration of BTP‐eC9 and facilitates an appropriate phase separation, favoring the enhanced crack onset strain of 17.69% compared to the D18/BTP‐eC9 film (9.67%). Combining with the optimal energy levels, prolonged carrier lifetime, and suppressed bimolecular recombination aroused by the incorporation of PM6‐b‐PYSe, the D18/PM6‐b‐PYSe/BTP‐eC9‐based OSC yields an encouraging efficiency of 17.97%. In particular, the device demonstrates excellent mechanical property, which can retain over 80% after 4000 bending cycles. This work provides an effective strategy to simultaneously enhance the intrinsic mechanical stretchability and photovoltaic performance of flexible OSCs.
Action Programmed Nanoantibiotics with pH‐Induced Collapse and Negative‐Charged‐Surface‐Induced Deformation against Antibiotic‐Resistant Bacterial Peritonitis
Authors: Zhang Xiao , Liu Penghui , Zhang Ran , Zheng Wenhong , Qin Di , Liu Yinghang , Wang Xin , Sun Tongyi , Gao Yuanyuan , Li Li‐Li 
Published: June 2024

AbstractThe incorporation of well‐designed antibiotic nanocarriers, along with an antibiotic adjuvant effect, in combination with various antibiotics, offers an opportunity to combat drug‐resistant strains. However, precise control over morphology and encapsulated payload release can significantly impact their antibacterial efficacy and synergistic effects when used alongside antibiotics. Here, this study focuses on developing lipopeptide‐based nanoantibiotics, which demonstrate an antibiotic adjuvant effect by inducing pH‐induced collapse and negative‐charged‐surface‐induced deformation. This enhances the disruption of the bacterial outer membrane and facilitates drug penetration, effectively boosting the antimicrobial activity against drug‐resistant strains. The modulation regulations of the lipopeptide nanocarriers with modular design are governed by the authors. The nanoantibiotics, made from lipopeptide and ciprofloxacin (Cip), have a drug loading efficiency of over 80%. The combination with Cip results in a significantly low fractional inhibitory concentration index of 0.375 and a remarkable reduction in the minimum inhibitory concentration of Cip against multidrug‐resistant (MDR) Escherichia coli (clinical isolated strains) by up to 32‐fold. The survival rate of MDR E. coli peritonitis treated with nanoantibiotics is significantly higher, reaching over 87%, compared to only 25% for Cip and no survival for the control group. Meanwhile, the nanoantibiotic shows no obvious toxicity to major organs.
Engineering Mesoscale T Cell Receptor Clustering by Plug‐and‐Play Nanotools
Authors: Sánchez M. Florencia , Faria Sevi , Frühschulz Stefan , Werkmann Lars , Winter Christian , Karimian Tina , Lanzerstorfer Peter , Plochberger Birgit , Weghuber Julian , Tampé Robert 
Published: June 2024

AbstractT cell receptor (TCR) clustering and formation of an immune synapse are crucial for TCR signaling. However, limited information is available about these dynamic assemblies and their connection to transmembrane signaling. In this work, TCR clustering is controlled via plug‐and‐play nanotools based on an engineered irreversible conjugation pair and a peptide‐loaded major histocompatibility complex (pMHC) molecule to compare receptor assembly in a ligand (pMHC)‐induced or ligand‐independent manner. A streptavidin‐binding peptide displayed in both tools enabled their anchoring in streptavidin‐pre‐structured matrices. Strikingly, pMHC‐induced clustering in the confined regions exhibit higher density and dynamics than the ligand‐free approach, indicating that the size and architecture of the pMHC ligand influences TCR assembly. This approach enables the control of membrane receptor clustering with high specificity and provides the possibility to explore different modalities of receptor activation.
Highly‐Aligned All‐Fiber Actuator with Asymmetric Photothermal‐Humidity Response and Autonomous Perceptivity
Authors: Zhang Yufan , Zhou Xinran , Liu Luyun , Wang Shuang , Zhang Yue , Wu Mengjie , Lu Zeren , Ming Zechang , Tao Jin , Xiong Jiaqing 
Published: June 2024

AbstractSoft robots adapt to complex environments for autonomous locomotion, manipulation, and perception are attractive for robot‐environment interactions. Strategies to reconcile environment‐triggered actuation and self‐powered sensing responses to different stimuli remain challenging. By tuning the in situ vapor phase solvent exchange effect in continuous electrospinning, an asymmetric highly‐aligned all‐fiber membrane (HAFM) with a hierarchical “grape‐like” nanosphere‐assembled microfiber structure (specific surface area of 13.6 m2 g−1) and excellent mechanical toughness (tensile stress of 5.5 MPa, and fracture toughness of 798 KJ m−3) is developed, which shows efficient asymmetric actuation to both photothermal and humidity stimuli. The HAFM consists of a metal‐organic framework (MOF)‐enhanced moisture‐responsive layer and an MXene‐improved photothermal‐responsive layer, which achieves substantial actuation with a bending curvature up to ≈7.23 cm−1 and a fast response of 0.60 cm−1 s−1. By tailoring the fiber alignment and bi‐layer thickness ratio, different types of micromanipulators, automatic walking robots, and plant robots with programmable structures are demonstrated, which are realized for self‐powered information perception of material type, object moisture, and temperature by integrating the autonomous triboelectric effect induced by photothermal‐moisture actuation. This work presents fiber materials with programable hierarchical asymmetries and inspires a common strategy for self‐powered organism‐interface robots to interact with complex environments.
Intramolecular Buchner Reaction: Experimental and Theoretical Comparison of the Effect of the Carbene Substituent on the Chemoselectivity
Authors: Tuyen Phung Bich , Medini Amira , Maldivi Pascale , Poisson Jean‐François , Bessières Bernard , Darses Benjamin 
Published: June 2024

AbstractThe intramolecular Buchner reaction is a powerful transformation able to dearomatize benzenic rings. However, the competitive C−H insertion of the carbene moiety into benzylic positions still remains a limitation, and the reasons governing this uncomplete chemoselectivity are poorly understood. The carbene substitution, in particular, has been observed to influence the selectivity strongly, though the currently proposed explanation relying on the electrophilicity of the metallocarbene hardly describes some experimental results reported in the literature. In this article, we present our experimental observations of intramolecular rhodium‐catalyzed Buchner reactions, combined with DFT calculations on selected carbene substituents, to propose a complementary explanation for the observed chemoselectivity modification.
Boosting Solar Water Splitting Performance of Cu3BiS3‐Based Photocathode via Ag Doping Strategy
Authors: Hu Yucheng , Shi Zhentao , Ren Xiaoliang , Cao Yuxi , Xiao Guohong , Huang Dingwang , Jiang Feng 
Published: June 2024

AbstractA photovoltaic wittichenite semiconductor of Cu3BiS3, due to its optimal bandgap, high light absorption coefficient, and various advantages of low cost and environmental‐friendliness, has been considered a competitive candidate for solar absorber materials of photocathode for photoelectrochemical water splitting. However, the presence of various deleterious defects in the Cu3BiS3 lattice and its high conduction band minimum are detrimental factors that restrict further enhancements in the conversion efficiency of Cu3BiS3‐based photocathode. Herein, a one‐step solution‐based Ag element doping strategy is proposed to improve the crystalline quality of Cu3BiS3 films, which includes enlarging the grain size and reducing the intergranular gaps. Additionally, the Ag‐doped Cu3BiS3 layer can form a more favorable band alignment with the buffer layer. Ultimately, the fabricated composite Cu3BiS3‐based photocathode doped with 3% Ag delivers a remarkable photocurrent density of 13.6 mA cm−2 under 0 VRHE, an applied bias photon‐to‐current efficiency of 2.85%, and long‐term stability exceeding 12 h. Furthermore, with the assistance of a BiVO4 photoanode, the tandem cell also achieves an unbiased solar‐to‐hydrogen efficiency of 2.64%, with no significant decline observed within 20 h.