bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat
Authors: Thakur Kuldeep Singh , Prakash Atish , Bisht Rohit , Bansal Puneet Kumar 
Published: January 2014

Introduction: Tardive dyskinesia is a serious motor disorder of the orofacial region, resulting from chronic neuroleptic treatment of schizophrenia. Candesartan (AT1 antagonist) and lisinopril (ACE inhibitor) has been reported to possess antioxidant and neuroprotective effects. The present study is designed to investigate the effect of candesartan and lisinopril on haloperidol-induced orofacial dyskinesia and oxidative damage in rats. Materials and methods: Tardive dyskinesia was induced by administering haloperidol (1 mg/kg i.p.) and concomitantly treated with candesartan (3 and 5 mg/kg p.o.) and lisinopril (10 and 15 mg/kg p.o.) for 3 weeks in male Wistar rats. Various behavioral parameters were assessed on days 0, 7, 14 and 21 and biochemical parameters were estimated at day 22. Results: Chronic administration of haloperidol significantly increased stereotypic behaviors in rats, which were significantly improved by administration of candesartan and lisinopril. Chronic administration of haloperidol significantly increased oxidative stress and neuro-inflammation in the striatum region of the rat’s brain. Co-administration of candesartan and lisinopril significantly attenuated the oxidative damage and neuro-inflammation in the haloperidol-treated rat. Conclusions: The present study supports the therapeutic use of candesartan and lisinopril in the treatment of typical antipsychotic-induced orofacial dyskinesia and possible antioxidant and neuro-inflammatory mechanisms.
Aldosterone-induced inflammatory response of mesangial cells via angiotension II receptors
Authors: Hao Jianbing , Ren Liansheng , Zhang Lei , Kong Deyang , Hao Lirong 
Published: January 2014

Introduction: In this study, we investigated whether AngII receptors (AT1a and AT2) contributed to the development of the aldosterone-induced inflammatory response of rat mesangial cells (RMCs). Materials and methods: RMCs were isolated from the glomeruli of normal or diabetic rats which were produced by injection of streptozotocin, and cultured in high-glucose media. In order to evaluate the effects of aldosterone, the expression of AT1a, AT2, NF-κB and MCP-1 was detected. In addition, in order to evaluate the role of Ang II receptors, AT1a and AT2 genes were blocked and the expression of NF-κB and MCP-1 was detected. Moreover, for assessing the relationship between NF-κB and MCP-1, the NF-κB gene was blocked and MCP-1 expression was detected. Results: Aldosterone significantly increased AT1a, AT2, NF-κB and MCP-1 levels in RMCs in a dose-dependent manner, whereas eplerenone (EPI), a selective aldosterone antagonist, partly inhibited the effects of aldosterone. When AT1a and AT2 genes were blocked, the expression of NF-κB and MCP-1 was greatly inhibited. Moreover, when the NF-κB gene was silenced, the expression of MCP-1 was reduced. Conclusion: We demonstrated that aldosterone induced an inflammatory response in RMCs cultured in high-glucose media via the AT1a and AT2 pathways.
Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma
Authors: Ye Bo , Ji Chun-Yu , Zhao Yi , Li Wang , Feng Jian , Zhang Xu 
Published: January 2014

Abstract

Background
Esophageal squamous incidence in many developed countries has increased dramatically over last decades, while the underlying mechanism of the biogenesis of ES was still unknown.

Methods
Here, we investigate 1001 subjects with esophageal cancer recruited from the affiliated hospital of Shanghai Jiao Tong University from Jan. 1, 2001 to Feb. 2, 2004. Single nucleotide polymorphism (SNP) of alcohol dehydrogenase-1B (ADH1B) was performed, and the recombinant plasimd containing ADH1B was constructed. Then, the ADH1B was purified and the enzymatic activity was assayed according to the methodology of Quayle. Furthermore, the effect of ADH1B on proliferation of human esophageal squamous cell lines was determined and the underlying mechanism of ADH1B was investigated.

Results
Logistic regression analyses revealed that subjects carrying the GG variant homozygote had a significant 2.81-fold (adjusted OR = 2.81; 95% CI = 2.18-3.62) increased risk of esophageal cancer. We found that SNP of ADH1B (GG) significantly promotes cell proliferation in ESGG. ADH1B (GG) could down-regulate endogenous ADH1B expression at posttranscriptional level. Moreover, re-expression of ADH1B in cells transfected with ADH1B (AA) significantly inhibits cell proliferation.

Conclusions
Our data implied that ADH1B (GG) could promote cell proliferation in human ESGG through regulating the enzyme activity of ADH1B. Therefore, we propose that ADH1B might be used as a therapeutic agent for human ESGG.
On the oscillation and asymptotic behavior for a kind of fractional differential equations
Authors: Wang Yizhuo , Han Zhenlai , Zhao Ping , Sun Shurong 
Published: January 2014

Abstract
In this paper, we discuss the oscillations of the fractional order differential equation

D
a
α

x
(
t
)
+
q
(
t
)
f
(
x
(
t
)
)
=
0

,

t
∈
[
a
,
+
∞
)

,

a
>
0

, where q is a positive real-valued function and f is a continuous functional;

D
a
α

denotes the Riemann-Liouville differential operator of order α,

0
<
α
≤
1

. We use the Riccati transformation technique to obtain some sufficient conditions which guarantee that every solution of the equation is oscillatory or the limit inferior converges to zero. Two examples are given to show the applications of our main results.

MSC:34A08, 34K11.
Disentangling Public Participation In Science and Biomedicine
Authors: Kelty Christopher , Panofsky Aaron 
Published: January 2014

Abstract
Background
This article provides a framework for disentangling the concept of participation, with emphasis on participation in genomic medicine. We have derived seven ‘dimensions’ of participation that are most frequently invoked in the extensive, heterogeneous literature on participation. To exemplify these dimensions, we use material from a database of 102 contemporary cases of participation, and focus here on cases specific to science and medicine. We describe the stakes of public participation in biomedical research, with a focus on genomic medicine and lay out the seven dimensions.

Discussion
We single out five cases of participation that have particular relevance to the field of genomic medicine, we apply the seven dimensions to show how we can differentiate among forms of participation within this domain.

Summary
We conclude with some provocations to researchers and some recommendations for taking variation in participation more seriously.
Structural and stratigraphic feature delineation and facies distribution using seismic attributes and well log analysis applied to a Brazilian carbonate field
Authors: Bueno Juliana Finoto , Honório Bruno César Zanardo , Kuroda Michelle Chaves , Vidal Alexandre Campane , Pereira Leite Emilson 
Published: January 2014

Identification of structural and stratigraphic components within a hydrocarbon reservoir is essential for the construction of geologic models that represent the facies distribution as accurately as possible. Such construction may represent a challenge for ancient carbonate reservoirs, which exhibit greater heterogeneity than siliciclastic reservoirs. We developed a workflow that incorporated seismic attribute analysis and well log data to highlight structural and architectural elements with the benefit of the understanding the distribution of facies in this features in an Albian offshore carbonate reservoir in Brazil. The proposed workflow combined incoherence, sweetness, and a new approach of spectral decomposition to delineate the main structural and architectural elements in the field. Well log facies and modern analog analyses were used to support the architectural elements’ interpretation. Joulters Cays is an oolitic shoal in the Bahamas that provided a modern analog for the field in study. Three main fault systems, responsible for the rollover structure of the field, were detected with the incoherence attribute. The workflow allowed the interpretation of four main architectural elements in the field: (1) tidal channels, (2) carbonate shoals, (3) reef, and (4) lagoons. Tidal channels and lagoons are mainly composed by wackestone. Carbonate shoals are primarily composed by grainstone with secondary packstone, while the reef crest is composed by packstone. Sequential indicator simulation (SIS) of well log facies supported these observations. The highlighted architectural elements could be helpful for the construction of a conceptual model of the field or useful as a training image for multiple-point statistics because SIS of well log facies does not define geologic bodies.
Loss of lysosomal protein NCU-G1 results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
Authors: Kong Xiang Yi , Nesset Cecilie K. , Damme Markus , Løberg Else-Marit , Lübke Torben , Mæhlen Jan , Andersson Kristin B. , Lorenzo Petra I. , Roos Norbert , Thoresen G. Hege , Rustan Arild C. , Kase Eili T. , Eskild Winnie 
Published: January 2014

Abstract
Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it has later been shown to be a bona fide lysosomal integral membrane protein. To gain insight into the physiological function of NCU-G1, mice with no detectable expression of this gene were created using a gene-trap strategy, and Ncu-g1gt/gt mice were successfully characterized. Lysosomal disorders are mainly caused by lack of or malfunctioning of proteins in the endosomal-lysosomal pathway. The clinical symptoms vary, but often include liver dysfunction. Persistent liver damage activates fibrogenesis and if unremedied eventually leads to liver fibrosis/cirrhosis and death. We demonstrate that the disruption of Ncu-g1 results in spontaneous liver fibrosis in mice as the predominant phenotype. Evidence for increased rate of hepatic cell death, oxidative stress and active fibrogenesis were detected in Ncu-g1gt/gt liver. In addition to collagen deposition, microscopic examination of liver sections revealed accumulation of autofluorescent lipofuscin and iron in Ncu-g1gt/gt Kupffer cells. As only a few transgenic mouse models have been identified with chronic liver injury and spontaneous liver fibrosis development, we propose that the Ncu-g1gt/gt mouse may be a valuable new tool in the development of novel treatments for attenuation of fibrosis due to chronic liver damage.
The concepts of work, study, and leisure of parents and children
Authors: Nota Laura , Ginevra Maria Cristina 
Published: January 2014

Abstract
The present work examines how a group of Italian parents and their adolescent children view work, study, and leisure in order to check for possible relations between the ideas of parents and their children’s. A total of 160 adolescents and 160 parents were recruited. Semi-structured interviews that assessed the participants’ concepts about work, study, and leisure were conducted. The analyses carried out demonstrate that there are connections between the parents’ and adolescents’ perceptions regarding work, study, and leisure. The results confirm the importance of considering both constructs and the parents’ perspectives on them, and of involving parents in their children vocational guidance actions.
Effect of latex powder and glass fibers on the performance of glazed hollow bead thermal insulation materials
Authors: Li Xiaolong , Li Guozhong 
Published: January 2014

AbstractGlazed hollow bead, cement, fly ash, and latex powder were used to prepare a glazed hollow bead thermal insulation material by way of compression molding, and the effects of redispersible latex powder on the mechanical properties and water resistance performance of the material were studied. In addition, the action mechanism of latex powder was analyzed. The surface of alkali-resistant glass fibers was treated by styrene-acrylic emulsion, and the effects of glass fibers on the mechanical properties of glazed hollow bead thermal insulation materials before and after treatment were studied, respectively. Moreover, the fracture morphology of the samples was observed and analyzed to explore the reinforced mechanism of fiber. The results show that when the dosage of latex powder is 4%, compared with blank samples, the sample’s flexural and compressive strengths increase by 48% and 20.83%, respectively, and the 2-h and 24-h water absorption of the samples is reduced by 71.37% and 66.94%, respectively. When the dosage of surface-treated fibers is 1.0%, the flexural strength of the samples increases by 35.71% and the compressive strength of the samples increases by 8.34% compared with samples that were mixed with untreated fibers.
The expression of predicative Possession in Lithuanian
Authors: Mazzitelli Lidia Federica 
Published: January 2014

AbstractThe object of this paper are the linguistic means used in Lithuanian to express predicative Possession. The possessive constructions are individuated and described, as along with the semantic constraints that favor or disfavor their use. It is claimed that the evidence provided in this paper confirms what Činčlej (1990) stated: Lithuanian should be considered as occupying a transitional position between the
The Impact of PCAOB Reports Containing Audit Deficiencies on Non-U.S. Audit Firms: Initial Evidence
Authors: Song HakJoon , Ye Zhongxia (Shelly) 
Published: January 2014

SUMMARY
The Public Company Accounting Oversight Board (PCAOB) regularly conducts inspections of non-U.S. audit firms. Based on 243 PCAOB inspection reports of non-U.S. audit firms, published by the PCAOB between January 2006 and December 2011, we examine involuntary dismissals, voluntary resignations, and voluntary deregistration of inspected non-U.S. audit firms following PCAOB reports containing audit deficiencies. Our results show that 24 out of 1,604 clients of non-U.S. audit firms have dismissed their auditors within one year following the disclosure of audit deficiencies in PCAOB reports, and that only four of these 24 clients appointed successor auditors with clean PCAOB reports. Also, we find only four auditor resignation cases from the 1,604 clients of non-U.S. audit firms within one year after they received a PCAOB report containing audit deficiencies. Finally, 22 non-U.S. audit firms voluntarily ceased to be registered with the PCAOB either during the inspection process or after they received PCAOB reports containing audit deficiencies. Compared to registered non-U.S. audit firms, these deregistered non-U.S. audit firms have relatively fewer resources (e.g., fewer partners and professional staff, smaller offices) and, thus, may not be able to bear compliance costs (e.g., costs associated with preparation for inspections) associated with PCAOB inspections. This study provides insights regarding the impact of PCAOB international inspections.
Properties of derivations on some convolution algebras
Authors: Pedersen Thomas 
Published: January 2014

Abstract
For all convolution algebras L
1[0, 1); L
loc1 and A(ω) = ∩n
L
1(ωn), the derivations are of the form D
μ
f = Xf * μ for suitable measures μ, where (Xf)(t) = tf(t). We describe the (weakly) compact as well as the (weakly) Montel derivations on these algebras in terms of properties of the measure μ. Moreover, for all these algebras we show that the extension of D
μ to a natural dual space is weak-star continuous.
Edwin Smith Papyrus Case 8: a reappraisal
Authors: Ganz Jeremy C. 
Published: January 2014

There are 3 translations of the Edwin Smith Papyrus: Breasted's (1930), Allen's (2005), and Sanchez and Meltzer's (2012). Case 8 is similarly presented in all 3 translations, although with increasing detail in the later works. The patient in Case 8 had a comminuted skull fracture under intact skin. There were palpable pulsations at the fracture site. There was deviation of the eye on the side of the injury and an ipsilateral spastic hemiparesis in an ambulant patient with bleeding from the nose and ear.
Explanations of the paralysis have included a contrecoup lesion and compression of the contralateral cerebral peduncle against the tentorial incisura. Brainstem compression due to herniation is accompanied by loss of consciousness. Extensive contrecoup lesions consistent with the extent of the described paresis would also be associated with probable coma. The paralysis was spastic, but spasticity takes weeks to develop after trauma. Yet this patient's trauma was fresh, as there was still bleeding from the nose and the ear.
It is suggested the paresis antedated the trauma, which was not its cause. The reasons for this suggestion are presented in this paper.
Capturing the sociomateriality of digital literacy events
Authors: Bhatt Ibrar , De Roock Roberto 
Published: January 2014

This paper discusses a method of collecting and analysing multimodal data during classroom-based digital literacy research. Drawing on reflections from two studies, the authors discuss theoretical and methodological implications encountered in the collection, transcription and presentation of such data. Following an ethnomethodological framework that co-develops theory and methodology, the studies capture digital literacy activities as real-time screen recordings, with embedded video recordings of participants’ movements and vocalisations around the tasks during writing. The result is a multimodal rendition of digital literacy events on- and off-screen, allowing linguistic and multimodal transcriptions to capture the complexity of the data in a format amenable to analysis. Acquiring such data allowed for the development of detailed analyses of digital literacy events in the classroom, including interaction that would otherwise have escaped standard ethnography and video analysis, through sensibilities that approach social and material items without a priori hierarchies. This leads us to a ‘performative’ notion of digital literacies and an analytic methodology that is useful for researchers paying greater attention to the sociomaterial assemblages in which digital literacy events unfold.Keywords: digital literacies; multimodality; video analysis; screen capture; literacy studies; actor-network theory(Published: 31 January 2014)Citation: Research in Learning Technology 2014, 21: 21281 - http://dx.doi.org/10.3402/rlt.v21.21281
The five resources of critical digital literacy: a framework for curriculum integration
Authors: Hinrichsen Juliet , Coombs Antony 
Published: January 2014

This article sets out a framework for a critical digital literacy curriculum derived from the four resources, or reader roles, model of critical literacy developed by Luke and Freebody (1990). We suggest that specific problematics in academic engagement with and curriculum development for digital literacy have occurred through an overly technocratic and acritical framing and that this situation calls for a critical perspective, drawing on theories and pedagogies from critical literacy and media education. The article explores the consonance and dissonance between the forms, scope and requirements of traditional print/media and the current digital environment, emphasising the knowledge and operational dimensions that inform literacy in digital contexts. It offers a re-interpretation of the four resources framed as critical digital literacy (Decoding, Meaning Making, Using and Analysing) and elaborates the model further with a fifth resource (Persona). The article concludes by identifying implications for institutional practice.Keywords: curriculum development; academic development; digital identity(Published: 31 January 2014)Citation: Research in Learning Technology 2014, 21: 21334 - http://dx.doi.org/10.3402/rlt.v21.21334
Editorial: Scholarship and literacies in a digital age
Authors: Friesen Norm , Gourlay Lesley , Oliver Martin 
Published: January 2014

There is growing interest in the impact of digital technologies on meaning-making practices and identity in education, which has been explored via the related concepts of ‘digital scholarship’ and ‘digital literacies’. However, to date, much published work in this area has been descriptive, identifying possibilities or promoting specific kinds of intervention. Far rarer is work that develops concepts, links to research outside of the field of learning technology or work that uses new data to challenge existing orthodoxies.(Published: 31 January 2014)Citation: Research in Learning Technology 2014, 21: 23834 - http://dx.doi.org/10.3402/rlt.v21.23834
Pour un nouveau modèle de développement centré sur l'essor des activités productives
Authors: Colletis Gabriel 
Published: January 2014

Austérité ou rigueur pour les uns, soutien de la croissance pour les autres. Mesures portant sur le budget pour les uns, sur la politique monétaire pour les autres. Réformes dites « structurelles » ou décroissance, les termes du débat sur l’orientation appropriée des politiques économiques mais aussi sur le devenir de nos économies sont particulièrement nombreux, souvent contradictoires, et traduisent un désarroi certain parmi les experts, les politiques mais aussi dans l’opinion publique. La thèse centrale que nous soutenons ici est que les politiques proposées dans les termes qui précèdent sont incapables de fournir l’horizon, le souffle nécessaire à une sortie de crise ou, plutôt, à la nécessaire mutation des systèmes socio-économiques. La perspective proposée dans ce papier est celle d’un nouveau modèle de développement à mettre en œuvre dans la durée. Une telle perspective consiste en un choix d’économie politique très fort : celui d’une nouvelle donne, un New Deal productif articulant une nouvelle conception du travail, un renouveau du sens des activités productives et une attention accrue quant à la nécessaire protection de la nature.
Endodontic management of horizontal root fractures in maxillary central incisors
Authors: Sathyanarayanan Kothandaraman 
Published: January 2014

AbstractRoot fracture implies fracture of cementum, dentin, and pulp. These injuries are relatively infrequent as they constitute <3% of all dental injuries. When a root fracture occurs horizontally, the coronal segment may or may not be displaced. This article illustrates two varied treatment options for horizontal root fractures in maxillary central incisors. In the first case, endodontic treatment was performed using a mineral trioxide aggregate (MTA)-based sealer. In the second case, repositioning and splinting of the teeth allowed revascularization and preservation of teeth vitality. A 12-month follow-up period was reported for the two cases.
Management of muslim dental patient while fasting
Authors: Peedikayil Faizal C. , Thomas Abraham , Naushad M. C. , Narayanan Arun 
Published: January 2014

AbstractThe dawn to dusk fast in the Islamic month of Ramadan is obligatory for all Muslims. During fasting, Muslims abstain from food, drink whilst going about their normal daily activities. Poor understanding and appreciation of the practices by the medical professional may lead to compromise in treatment and inability to provide good service for the patients. This article provides insight to dentists around the globe to carry out comprehensive and preventive dental treatment to fasting patients in the month of Ramadan.