bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective autophagy of ribosomes balances a tradeoff between starvation survival and growth resumption
Authors: Tuomaala Joel , Sankar Devanarayanan Siva , Perey Julie , Psalmon Sacha , Stroustrup Nicholas , Dengjel Joern , Towbin Benjamin D. 
Published: August 2024

AbstractIn environments with fluctuating nutrient abundance, organisms must survive periods of starvation, yet quickly resume growth upon food encounter. A tradeoff between these objectives is well-documented in microbes, where it is caused by the need to partition the total cellular protein content between growth- and survival-enhancing proteins. However, the molecular mechanisms of growth-survival tradeoffs in multicellular animals remain largely unknown. Here, we addressed this mechanism forC. elegansby measuring the dynamic changes of its proteome during starvation using live imaging and proteomics. We found that starved animals catabolize ribosomal proteins through autophagy, which provides essential energy for survival while preserving organismal integrity. However, the resulting decline in ribosomes delayed growth resumption upon refeeding until pre-starvation ribosome levels were restored. Genetic inhibition of ribosomal autophagy had a dual effect: although it accelerated growth after short starvation, it compromised survival during prolonged starvation. These findings reveal the rate of ribosomal catabolism as a key determinant of a tradeoff between starvation survival and rapid growth resumption whose tuning may adapt animals to different starvation durations. Our research shows how the need to balance protein allocation between growth and survival constrains animal physiology, highlighting the mechanistic role of proteome resource limitation in whole-organism tradeoffs.
Identification of a new ORF3a-E fusion subgenomic RNA of SARS-CoV-2 and its biological features in the infection process
Authors: Zhang Yifan , Zheng Huiwen , Li Jing , Zhang Xinglong , Zhang Xin , Li Jiali , Li Heng , Zhao Xin , Zhang Zihan , Li Yingyan , Chen Keqi , Peng Shasha , Zhang Ying , Shi Haijing , Liu Longding 
Published: August 2024

AbstractSubgenomic RNAs (sgRNAs) are discontinuous transcription products of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are involved in viral gene expression and replication, but their exact functions are still being studied. Here, we report the identification of a new type of sgRNA, the fusion ORF3a-E-sgRNA, involved in the infection process of SARS-CoV-2. This sgRNA codes both ORF3a and E and can be detected throughout the viral life cycle in SARS-CoV-2-infected cells with high copy numbers. ORF3a-E-sgRNA guides more ORF3a translation and promotes the expression of cellular ribosomal protein S3 (RPS3) and the binding of eukaryotic translation initiation factor 4E (eIF4E). Single-cell sequencing of a SARS-CoV-2-infected human bronchial epithelial cell line (16HBE) revealed that maintenance of this stable translational environment by ORF3a-E-sgRNA is important for the SARS-CoV-2 assembly and release capabilities and is also beneficial for viral evasion of host innate immunity. More importantly, the transcription level of ORF3a-E-sgRNA contributes to differences in infection processes between the Wuhan strain and XBB strain of SARS-CoV-2.
PICASO: Profiling Integrative Communities of Aggregated Single-cell Omics data
Authors: Joppich Markus , Kramann Rafael , Hayat Sikander 
Published: August 2024

AbstractVarious single-cell modalities covering transcriptomics, epigenetic and spatio-temporal changes in health and disease phenotypes are used in an exploratory way to understand biological systems at single-cell resolution. However, the vast amount of such single-cell data is not systematically linked to existing biomedical data. Networks have previously been used to represent harmonized biomedical data. Integrating various resources of biomedical data in networks has recently received increasing attention. These aggregated networks can provide additional insight into the biology of complex human diseases at cell-type level, however, lack inclusion of single cell expression data. Here, we present the PICASO framework, which incorporates single-cell gene expression data as an additional layer to represent associations between cell types, disease phenotypes, drugs and genes. The PICASO network includes several standardized biomedical databases such as STRING, Uniprot, GeneOntology, Reactome, OmniPath and OpenTargets. Using multiple cell type-specific instances of the framework, each annotated and scored with their respective expression data, comparisons between disease states can be made by computing respective sub-networks and comparing the expression scores between conditions. Ultimately, these group-specific networks will allow the identification of relevant genes, processes and potentially druggable targets, as well as the comparison of different measured groups and thus the identification of group-specific communities and interactions.
Dietary zinc limitation dictates lifespan and reproduction trade-offs ofDrosophilamothers
Authors: Sarmah Sweta , Truong Hannah Thi-Hong Hanh , McColl Gawain , Burke Richard , Mirth Christen K , Piper Matthew DW 
Published: August 2024

AbstractDietary metal ions significantly influence the lifespan and reproduction ofDrosophilafemales. In this study, we show that while the depletion of all metal ions from the diet adversely affects reproduction and lifespan, the absence of Zn alone negatively impacts reproduction without adversely altering maternal lifespan, indicating it can dictate resource reallocation between key fitness traits. Although our data show that flies sense varying dietary Zn levels, they apparently do not alter their feeding preferences to optimise egg production when faced with a choice between Zn- depleted or Zn- sufficient food, but they can choose to preferentially oviposit on Zn containing food, perhaps indicating a strategy to assure offspring survival. We also uncovered a role for thewhitegene in sustaining high levels of egg viability when Zn is diluted in the diet. These insights into the role of dietary metal ions, particularly Zn, point to a central role for these dietary micronutrients to indicate environmental quality and so govern trade-offs between lifespan and reproduction in flies.
HIRA defines early replication initiation zones independently of their genome compartment
Authors: Karagyozova T. , Gatto A. , Forest A. , Quivy J.-P. , Marti-Renom M. , Mirny L. , Almouzni G. 
Published: August 2024

AbstractChromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the histone H3.3 chaperone HIRA, which plays a role in both early initiation zone (IZ) definition and higher-order organisation of active chromatin. We monitored in parallel early replication initiation, chromatin accessibility, histone post-translational modifications (PTMs) and 3D organisation in wild-type cells, HIRA knock-out cells and HIRA knock-out cells complemented with HIRA. In the absence of HIRA, impaired early firing at HIRA-dependent IZs does not correspond to changes in chromatin accessibility or patterns of histone H3 PTMs. With respect to 3D organisation, a small subset of early IZs initially in compartment A switched to B and lost early initiation in the absence of HIRA. Critically, HIRA complementation restores these early IZ (and H3.3 variant enrichment) without substantial compartment reversal. Thus, our work reveals that regulation of early replication initiation by HIRA can be uncoupled from accessibility, histone mark patterns and compartment organisation.
Two-photon production of
f0
and
a0
resonances as hadronic molecules composed of two vector mesons
Authors: Yang Li-Ke , Wang Zheng-Li , Wu Jia-Jun , Zou Bing-Song 
Published: August 2024

Ascribed as ρρ and K*K¯* molecular states, respectively, isoscalar f0(1500) and f0(1710) states are expected to have isovector partners, potentially identified as a0(1450) and a0(1710). The predicted dominant decay modes for these two a0 resonances are a0(1450)→ωππ and a0(1710)→ωππ,ϕππ. We estimate cross sections for two-photon production of these four resonances within hadronic molecular picture, and demonstrate that SuperKEKB’s luminosity is sufficient for their observation and more precise parameter measurements.

Published by the American Physical Society
2024
Multi-step commodity forecasts using deep learning
Authors: Bora Siddhartha S. , Katchova Ani L. 
Published: August 2024

PurposeLong-term forecasts about commodity market indicators play an important role in informing policy and investment decisions by governments and market participants. Our study examines whether the accuracy of the multi-step forecasts can be improved using deep learning methods.Design/methodology/approachWe first formulate a supervised learning problem and set benchmarks for forecast accuracy using traditional econometric models. We then train a set of deep neural networks and measure their performance against the benchmark.FindingsWe find that while the United States Department of Agriculture (USDA) baseline projections perform better for shorter forecast horizons, the performance of the deep neural networks improves for longer horizons. The findings may inform future revisions of the forecasting process.Originality/valueThis study demonstrates an application of deep learning methods to multi-horizon forecasts of agri-cultural commodities, which is a departure from the current methods used in producing these types of forecasts.
Looking beyond transactions: decoding the role of service innovation, relationship commitment and fairness in driving customer satisfaction in retail banking
Authors: Biswas Abhijeet , Kant Rishi , Jaiswal Deepak 
Published: August 2024

PurposeA significant increase in the number of private sector banks has intensified the level of competition in the Indian banking industry (IBI). This increase in the number of banks has a considerable impact on the existing players, which calls for prioritizing customer satisfaction (CS) and enhancing bank reputation (BR). Our study seeks to investigate the enablers of CS and BR in the IBI.Design/methodology/approachThe study adopted a cross-sectional design for gathering responses from retail bank customers across the selected banks through a structured questionnaire. Structural equation modeling (SEM) was utilized to evaluate direct and indirect linkages among the identified constructs by examining mediating and moderating effects.FindingsThe study puts forward crucial antecedents of CS and BR. The findings exhibit that perceived trust (PT) and relationship commitment (RC) magnify CS and BR, respectively, while CS amplifies repurchase intention (RI). The study advances that BR and CS partially mediate between the underlying constructs. In addition, fairness and risk exhibit moderating effects between CS and customer repurchase intention (CRI) and BR and CRI.Research limitations/implicationsThe study illustrates the crucial enablers of BR, CS and CRI that may assist banking professionals in enriching customer experience and holding on to their customers.Originality/valueThere is a shortage of research on RC, service innovation (SI) and BR in the IBI. Accordingly, our study builds on the prior studies by considering these constructs using a comprehensive conceptual framework by extending the application of signaling theory (ST) in the banking domain and scrutinizing the dual moderating effects of fairness and risk.
Voluntary overqualification: conceptualization, scale development and validation
Authors: Li Yi , Yan Menghan , Fang Jianfeng , Wei Feng 
Published: August 2024

PurposeWith the diversification of professional values, an increasing number of individuals voluntarily choose positions that demand less than their personal knowledge, skills and educational background, a phenomenon known as voluntary overqualification. This study aims to explore the reasons for discerning the motivations driving voluntary overqualification, define its conceptual content and develop the measurement scale for voluntary overqualification.Design/methodology/approachThrough five phases, and using both qualitative and quantitative approaches, the authors constructed a scale comprising three dimensions: earnings-oriented, life-oriented and meaning-oriented to measure voluntary overqualification. Following the steps of scale development, the conceptual connotation and structural dimensions of voluntary overqualification were systematically coded and mined based on grounded theory. The scale’s reliability and validity were measured through exploratory and validation factor analyses. Finally, the validity of the voluntary overqualification scale was verified through the selection of professional identity and subjective well-being.FindingsThis study defined connotations and structural dimensions of voluntary overqualification based on grounded theory, resulting in a measurement scale with three dimensions and 13 items. These dimensions include earnings-, life- and meaning-oriented voluntary overqualification. Empirical testing of predictive validity used professional identity and subjective well-being as outcome variables.Originality/valueThis study provides a theoretical foundation and an effective measurement tool for subsequent research in voluntary overqualification by focusing on a new type of voluntary overqualification, defining its connotations and developing a complete set of scales.
Conceptualising project management capabilities for offsite construction
Authors: Ginigaddara Buddhini , Ershadi Mahmoud , Jefferies Marcus , Perera Srinath 
Published: August 2024

PurposeRecent research advocates that there are plenty of opportunities for key players in the offsite construction (OSC) sector to harness the full potential of advanced project management techniques. While previous research mainly focuses on transformations related to digital and advanced technologies driven by industry 4.0 principles, a research gap still exists on the intersection of project management capabilities and OSC. This study attempts to bridge this gap by capturing the homogeneity of different capabilities and integrating them into an overarching framework.Design/methodology/approachA scientometric analysis is conducted to provide an overview of the co-occurrence network of keywords in the representative studies. A systematic literature review (SLR) of articles published between 2010 and 2022, followed by a subsequent full-text examination of 63 selected articles, revealed 34 interrelated capabilities to be categorised under three exhaustive planning-oriented, design-oriented and delivery-oriented groups.FindingsThis review revealed an upward trend of publication on project management capabilities for OSC with a specific interest in optimisation of resources allocated to offsite operations. The top five capabilities discussed more frequently in the literature include (1) artificial intelligence for design error detection, (2) enhanced resource productivity, (3) cost saving in offsite production, (4) real-time traceability of modules and (5) applying lean agile production principles to OSC, which imply the critical role of quality, cost saving, traceability and agility in OSC.Originality/valueThis study elicits core capabilities and develops a new offsite project management framework for the first time. The authors provide directions for researchers and practitioners to apply capabilities for obtaining better outcomes and higher value out of offsite operations.
Dynamics of hate speech in social media: insights from Indonesia
Authors: Margono Hendro , Saud Muhammad , Ashfaq Asia 
Published: August 2024

PurposeSocial media provides a platform for people to connect, communicate and share their opinions, and has become a powerful gizmo for freedom of expression as well as freedom of speech. The present study intends to examine the role of social media in instigating hateful thoughts, actions among youth and eventually leading them towards hate speech.Design/methodology/approachMixed methods were adopted to achieve the objectives, where survey (quantitative) and focus group discussions (qualitative) were carried out. The students who participated were from different universities, campuses and faith-based schools in Indonesia. They were recruited through online and offline sources where they showed their interest in participating in this study. Participants were 19–30 years old. Data was analysed by deploying the narrations, thematic (based on themes), and univariate analysis.FindingsIn the present research, three attributes of hate speech were investigated, such as form of expression, discrimination and identity factors. The findings of the study show that the prevalence of hate speech among youth in Indonesia is associated with their belongingness to political ideology, identity, nationality and ethnicity.Social implicationsThe objective is to examine the prevalence and nature of hate speech among youth in Indonesia, identify the factors and reasons for engaging in hate speech and assess the potential impacts of hate speech.Originality/valueThis research attempts to analyse the role of social media in shaping the mindset of the youth towards hate speech, which ultimately leads to delinquency.
Travelling with open eyes! A study to measure consumers’ intention towards experiencing immersive technologies at tourism destinations by using an integrated model of TPB, TAM captured through the lens of S-O-R
Authors: Sujood  , Pancy  
Published: August 2024

Purpose
Immersive technologies fully immerse users in augmented environments for interactive experiences. The purpose of this study is to measure consumers’ intention towards experiencing immersive technologies at tourism destinations using an integrated theory of planned behaviour (TPB) and technology acceptance model (TAM) model within the stimulus-organism-response (S-O-R) framework, including motivation (MOT), trust (TR) and perceived risk (PR).

Design/methodology/approach
The survey data was collected through convenience sampling via an online questionnaire, with a sample size of 487 Indians. Structural equation modelling was conducted using SPSS and AMOS software for data analysis, ensuring a robust examination of the proposed model and its relationships.

Findings
Virtual interactivity and social interaction influence both attitude and perceived behavioural control. Attitude, perceived behavioural control, perceived usefulness and TR significantly influence intention. However, MOT, PR and perceived ease of use do not exhibit a significant influence on intention. These findings highlight the importance of these variables in shaping consumers’ intention towards experiencing immersive technologies at tourism destinations.

Research limitations/implications
The findings hold significant implications for various stakeholders, including government agencies, travel firms, content creators and software developers. They can leverage these insights to enhance marketing strategies, develop immersive tourism experiences, innovate in the realm of Web 4.0 and personalize tourism offerings.

Originality/value
This study offers a distinctive contribution by integrating the S-O-R framework with TPB and TAM, while also incorporating key factors such as MOT, TR and PR. This novel approach provides a fresh perspective on consumer behaviour towards immersive technologies.
Impact of sustainable supply chain management practices on competitive advantage and organizational performance in the manufacturing sector
Authors: Shebeshe Ephrem Negash , Sharma Dhiraj 
Published: August 2024

PurposeThe purpose of this study is to examine the impact of sustainable supply chain management (SSCM) practices on both competitive advantage (CA) and organizational performance (OP) in the manufacturing sector in Ethiopia.Design/methodology/approachData for the study were collected from a sample of 221 manufacturing companies operating in the four manufacturing groups/sectors in Ethiopia. In addition, data analysis was performed using the partial least squares method, which is a variance-based Structural Equation Modeling approach in the Smart-PLS software version (SmartPLS 4.0).FindingsBased on the statistical analysis of the collected data, it demonstrates that SSCM has a significant and positive impact on both competitive advantage and organizational performance. Furthermore, statistical findings offer proof of the clear connection between competitive advantage and organizational performance. Moreover, competitive advantage indirectly mediates the relationship between SSCM and OP.Research limitations/implicationsThe primary limitation of this research is its reliance on a cross-sectional design. The generalizability of the findings obtained from the present study may be hindered. The variable under investigation in this research assessed organizational performance, a concept that is widely acknowledged to be extremely dynamic.Practical implicationsThe study provides managers and researchers with valuable information on Sustainable Supply Chain Management strategies and how they influence competitive advantage and organizational performance in commercial and industrial environments.Originality/valueThis paper adds to the body of knowledge by providing new data and empirical insights into the relationship between SSCM practices and the performance of manufacturing companies in Ethiopia.
Technical academia goes back to school: the role of universities in environmental and sustainable education for childhood
Authors: Comino Elena , Dominici Laura , Reyneri Anna , Treves Anna 
Published: August 2024

Purpose
This paper aims to investigate the relationship between academia and society focusing on how technical universities perform Third Mission (TM) to promote knowledge outside the academic environment producing multiple benefits.

Design/methodology/approach
This investigation is performed through the conceptual approach. The theoretical background of the TM is explored through scientific literature review. It analyses a selected pool of experiences focused on Environmental and Sustainable Education (ESE). The study identifies significant aspects of two specific case studies, designed and implemented by the authors.

Findings
Outcomes show opportunities and limitations in the application of ESE on behalf of technical academia. The study suggests solutions, precautions and systemic changes to promote ESE for childhood as TM activity in technical engineering academia. These recommendations can be useful for policymakers to set academic goals and plan the strategic management of teaching, research and TM.

Originality/value
The paper focuses on the role of technical engineering universities and criticalities faced by academics to foster and perform ESE. Future perspectives aim to create new opportunities to strengthen the social impact of scientific and technical research by building bridges with childhood education.