bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coenzyme Q10 supplementation affects cellular ionic balance: relevance to aging
Authors: Srivastava Parisha , Bhoumik Sukanya , Yadawa Arun K. , Kesherwani Rashmi , Rizvi Syed Ibrahim 
Published: July 2024

Abstract
Aging results into disruptive physiological functioning and cellular processes that affect the composition and structure of the plasma membrane. The plasma membrane is the major regulator of ionic homeostasis that regulates the functioning of membrane transporters and exchangers. Coenzyme Q10 is a lipid-soluble antioxidant molecule that declines during aging and age-associated diseases. The present study aims to explore the role of Coenzyme Q10 supplementation to rats during aging on membrane transporters and redox biomarkers. The study was conducted on young and old male Wistar rats supplemented with 20 mg/kg b.w. of Coenzyme Q10 per day. After a period of 28 days, rats were sacrificed and erythrocyte membrane was isolated. The result exhibits significant decline in biomarkers of oxidative stress in old control rats when compared with young control. The effect of Coenzyme Q10 supplementation was more pronounced in old rats. The functioning of membrane transporters and Na+/H+ exchanger showed potential return to normal levels in the Coenzyme Q10 treated rats. Overall, the results demonstrate that Coenzyme Q10 plays an important role in maintaining redox balance in cells which interconnects with membrane integrity. Thus, Coenzyme Q10 supplementation may play an important role in protecting age related alterations in erythrocyte membrane physiology.
A TEORIA DA CEGUEIRA DELIBERADA NO DIREITO BRASILEIRO
Authors: Barbosa Stella Aguiar , Da Silva Luiza Silveira 
Published: July 2024

Resumo: A teoria da cegueira deliberada (willful blindness) serve para punir agentes que se colocam, deliberadamente, em situação de ignorância quanto a elementos penalmente relevantes, dando causa a uma conduta ilícita, com o intuito de eximir-se de eventual responsabilidade penal. É um instituto originário do direito estrangeiro e, por tal razão, é indispensável que seja feito um estudo acerca da possibilidade da sua importação para o ordenamento jurídico brasileiro. Além disso, trata-se de um tema com diversos pontos controversos e de muita discussão pelos aplicadores e estudiosos da ciência jurídica criminal. Dessa maneira, o presente estudo objetiva analisar a compatibilidade da presente teoria com o sistema jurídico pátrio. Nesse sentindo, será feita uma breve análise sobre sua origem histórica e seu surgimento no Brasil, bem como dos pontos conflitantes a serem superados para que seja possível a sua compatível e efetiva transposição ao ordenamento brasileiro. Palavras-chave: Teoria da cegueira deliberada; Ordenamento jurídico brasileiro; Compatibilidade. Abstract: Willful blindness theory serves to punish agents who deliberately put themselves on an ignorance position concerning relevant criminal elements and, doing so, they cause illicit conduct excusing them of eventual criminal responsibilization. This theory was originated on foreign law and so it is indispensable to carry a study about the possibility of its importation to the Brazilian legal system. Besides, it is a theme with several controversial points which provokes many discussions among jurists and criminal law scientists. For so, the present study analyzes the compatibility between this theory and the Brazilian national legal system. In this sense, it will be made a brief analysis of its historical origins and its emergence in Brazil, such as about the conflicting points which need to be overcome in order to be possible its compatible and effective transposition to the national legal system. Keywords: Willful blindness theory; Brazilian legal system; Compatibility. Sumário: Introdução. 1. Da teoria da cegueira deliberada. 1.1 Conceito. 1.2 Breves considerações sobre a origem histórica e evolução. 2. O dolo no Código Penal Brasileiro. 2.1 Panorama geral do dolo no direito pátrio. 2.2. Cegueira deliberada e o dolo eventual – a problemática em torno da equiparação dos institutos. 3. A cegueira deliberada e o instituto penal do erro de tipo. 4. Da Common Law à Civil Law: críticas acerca da importação da teoria. 5. A teoria sob a égide do princípio constitucional da legalidade. 6. Da importação à aplicação: a teoria no âmbito dos tribunais.
A EMPRESA EM CRISE: POR UMA MINORAÇÃO DAS INFORMAÇÕES ASSIMÉTRICAS NA LEI 11.101/05
Authors: Lana Henrique Avelino , Pimenta Eduardo Goulart 
Published: July 2024

Resumo: Pretende-se neste trabalho, via Análise Econômica do Direito, identificar, de forma construtiva, que a atual redação da Lei 11.101/05 enseja assimetria de informações, o que contribui para a sua ineficiência. A metodologia a ser utilizada é de método dedutivo, mediante abordagem explicativa e descritiva, além de pesquisa bibliográfica. Inicialmente será feita uma contextualização do tema, mediante abordagem dos princípios da função social e preservação da empresa. Após, serão identificados os aspectos existentes na Lei de Recuperação de Empresas e Falência que permitem afirmar que há, sim, forte ensejo à assimetria de informações. Palavras-chave: Recuperação de empresas; Falência; Assimetria de Informações. Abstract: This work, through Economic Analysis of Law, aims to constructively identify the current wording of Statute no. 11,101 / 05 asymmetry of information, which contributes to its inefficiency. The methodology to be used is a deductive method, through an explanatory and descriptive approach, as well as bibliographic research. Initially a contextualization of the theme will be made, by approaching the principles of social function and preservation of the company. Afterwards, the aspects in the Law on Corporate Recovery and Bankruptcy will be identified, which allow us to affirm that there is a strong opportunity to asymmetry of information. Keywords: Recovery of companies; Bankruptcy; Asymmetry of Information. Sumário: Introdução. 1. A Lei 11.101/05 e sua essência: a empresa em crise. 2. A possibilidade de aperfeiçoamento da Lei 11.105/05. 3. A necessidade de redução das informações incompletas ou assimétricas. Considerações finais. Referências.
O LAUDO PERICIAL CINÉTICO-FUNCIONAL NA JUSTIÇA DO TRABALHO
Authors: De Carvalho Mendes Gillian Santana , Martins Guimarães Lélio Jairo 
Published: July 2024

Resumo: O presente estudo teve como objetivo analisar a importância e validade do exame pericial fisioterapêutico cinético-funcional, nos casos de LER (Lesão por Esforço Repetitivo) ou DORT (Distúrbio Osteomuscular Relacionado ao Trabalho), estabelecendo sua repercussão no âmbito da Justiça do Trabalho, haja vista a necessidade de apoio técnico de outros profissionais ao magistrado em situações que ultrapassam sua competência técnico-jurídica. Trata-se de pesquisa teórica exploratória, de natureza descritiva e explicativa, de interpretação sistemática, e técnica de pesquisa bibliográfica e documental, utilizando-se de teorias, doutrina, legislação e jurisprudência, especialmente do Tribunal Regional do Trabalho da 22ª Região. Concluiu-se que o número de casos de LER e DORT são significativos e que possivelmente, diante de conflito entre empregado e empregador, o judiciário será buscado, e o juiz, diante do caso concreto, indicará perito para realização do laudo pericial a fim de que seja diagnosticada ou não a incapacidade laboral, sendo o fisioterapeuta profissional o mais indicado para tal mister. Palavras-chave: LER/DORT; Prova Pericial; Laudo Cinético-Funcional por Fisioterapeuta. Abstract: The present study aimed to analyze the importance and validity of the kinetic functional physiotherapeutic expert examination, in the case of RSI (Repetitive Strain Injury) or WMSD (Work-Related Musculoskeletal Disorder), establishing its repercussion within the scope of Labor Justice, considering the need for technical support from other professionals to the judge in situations that go beyond their technical-legal competence. This is exploratory theoretical research, of a descriptive and explanatory nature, with systematic and technical interpretation of bibliographic and documentary research, using theories, doctrine, legislation and case law, especially from the Brazilian Regional Labor Court of the 22nd Region. It was concluded that the number of cases of RSI and WRMSD are significant and that possibly, in the face of conflict between employee and employer, the judiciary will be sought, and the judge, in the specific case, will appoint an expert to carry out the expert report in order to diagnose work disability or not, and the professional physiotherapist is most suitable for this task. Keywords: RSI/WRMSD; Expert Evidence; Kinetic-Functional Report by Physiotherapist. Sumário: Introdução. 1. Os distúrbios relacionados ao trabalho: LER/DORT. 2. Reconhecimento das doenças ocupacionais. 3. Causas/Etiologias mais comuns a LER/DORT conforme a legislação. 4. A importância da escolha do perito para realização do laudo pericial. 5. O laudo pericial cinético-funcional elaborado por Fisioterapeuta e sua repercussão na esfera jurídica. 6. Elementos do laudo pericial cinético-funcional. 7. Análise dos processos em que foi solicitada a perícia cinético-funcional pelo TRT da 22ª região nos casos de LER e DORT. Considerações finais. Referências.
PRISÕES, DANO SOCIAL E CONTEXTOS CONTEMPORÂNEOS
Authors: Rotta Almeida Bruno , Pimentel Elaine , Cacicedo Patrick 
Published: July 2024

O enfrentamento da crise humanitária das prisões brasileiras, especialmente diante da pandemia da Covid-19, requer uma reversão do processo de encarceramento em massa vivido pelo país nas últimas décadas e a implementação de políticas públicas garantidoras de direitos fundamentais nas prisões. Mais especificamente, a dignidade de centenas de milhares de pessoas demanda uma urgente efetivação de políticas públicas integradas de saúde nas prisões e desencarceramento. É nesse sentido que o presente volume destaca o necessário tema do dano social advindo das prisões no mundo contemporâneo, que ultrapassa as dores impostas à população prisional e se espraia de forma negativa em diversos aspectos da vida social. A produção a seguir apresentada revela justamente essa preocupação a partir de diversos pontos de vistas e também de realidades sociais distintas
Educación combinada en tiempos de pandemia: un estudio de caso en la Dirección Regional de Educación Norte-Norte, Costa Rica
Authors: López Estrada Patricia , Pérez Hidalgo Estefanía , Elizondo Mejías Jonathan 
Published: July 2024

En 2020, la pandemia que surgió a raíz del COVID-19 afectó los sistemas educativos del mundo. En Costa Rica, el Ministerio de Educación Pública (MEP) interrumpió el curso lectivo en marzo y adoptó una modalidad educativa basada en la educación a distancia. A finales de ese mismo año, las autoridades decidieron realizar un retorno paulatino a la presencialidad durante el curso lectivo 2021. Esta nueva modalidad se conoció como Educación Combinada. El propósito del estudio fue describir las percepciones de seis docentes de inglés de primaria de la región Huetar Norte con respecto a la modalidad de educación combinada para una visión más amplia de los procesos de mediación pedagógica y del contexto inmediato de las personas docentes durante la crisis sanitaria. El presente estudio de investigación cualitativo-inductivo, con un diseño de estudio de caso descriptivo, recolectó y trianguló datos mediante el uso de entrevistas semiestructuras, recolección de documentación y fotoelicitación. Mediante el análisis de contenido, se categorizaron y analizaron los datos obtenidos de seis personas docentes de inglés de primaria mediante el uso del software ATLAS.ti. Los resultados exponen sentimientos vividos por las personas docentes, así como mecanismos de autoeficacia que emplearon durante la pandemia. También, se presentan conclusiones sobre la gestión de los aspectos pedagógicos correspondientes al planeamiento didáctico, mediación pedagógica, evaluación de los aprendizajes, procesos de aprendizajes y alcance de los contenidos priorizados del año lectivo. Es crucial que se impulsen estrategias para reducir el impacto del rezago educativo y que se fomenten iniciativas que fortalezcan el empoderamiento regional, donde las escuelas y direcciones regionales de educación asuman un papel central en sus propias comunidades, dado que son ellos quienes poseen un conocimiento directo de las realidades educativas locales.
Exploring Hungarian teachers' perceptions of project-based learning in science and math education
Authors: Kasbary Nicole , Haymour Aghnar 
Published: July 2024

AbstractProject-based learning (PJBL) emerges as an instructional teaching method promoting collaboration, critical thinking, and problem-solving skills among students. This pedagogical approach facilitates active engagement by forming student groups to collaboratively create and develop projects, thus, encouraging the exploration of diverse perspectives and ideas within the classroom. The PJBL approach departs from traditional learning methods and offers students opportunities for enjoyment, active participation, self-expression, and creativity. PJBL instills valuable teamwork skills from a young age by equipping students with essential resources for their future endeavors through immersive experiences. This article focuses on Hungarian teachers' perspectives on PJBL by employing a qualitative approach. The study conducts semi-structured interviews with nine educators to unravel their insights on the advantages and challenges of implementing PJBL in the classroom. The paper explores the nuanced views of Hungarian teachers and aims to provide a comprehensive understanding of how PJBL is perceived in the educational landscape. The findings contribute valuable insights to the broader discourse on project-based learning displaying a context-specific lens on the perceptions of educators in Hungary and enriching the understanding of PJBL's dynamics within the educational settings.
Emotional interference and attentional bias in compulsive sexual behaviors disorder – An fMRI study on heterosexual males
Authors: Draps Małgorzata , Kulesza Maria , Glica Agnieszka , Szymanowska Julia , Lewińska Katarzyna , Żukrowska Weronika , Gola Mateusz 
Published: July 2024

AbstractBackground and aimsDespite the inclusion of the Compulsive Sexual Behavior Disorder (CSBD) in the 11th edition of the International Classification of Diseases, emotional and cognitive impairments related to CSBD remains unclear. This study aimed to investigate the behavioral and neuronal effects of emotional interference on cognition among CSBD patients.MethodsThirty heterosexual males with CSBD and matched healthy controls (HC) were studied with the Emotional Stroop Task using 5 categories of emotionally arousing words (sex-related, positive, fear-related, negative, neutral) during functional magnetic imaging.ResultsAt the behavioral level, we found the main effect of the condition: sex-related words evoked a stronger Stroop effect than other conditions. At the neural level, we found a significant group effect. Among CSBD patients processing of sex-related words was related to increased activity in the right putamen, right thalamus, hippocampi, and left pulvinar, when compared to HC. We also found a negative correlation between neuronal activation and time spent on sexual activity during the week preceding study and numerous group differences in brain regions connected to the emotional and motivational processing of sexually explicit material, correlating with CSBD symptoms.ConclusionsBehavioral results indicate a specific attentional bias toward sex-related stimuli in both groups, while neural data uncovered stronger reactivity to sex-related words in CSBD compared to HC. This reactivity is related to CSBD symptoms and provides evidence for the interference of sex-related stimuli with cognition. Such results are firmly in line with the Incentive Salience Theory and conceptualizing CSBD as a behavioral addiction.
Panel Data Analysis of Two Level Mixed Linear Models for Factors Affecting The Health Index in West Java
Authors: Awalluddin Asep Solih , Khumaeroh Mia Siti , Amalia H. , Wahyuni Inge 
Published: July 2024

The purpose of this study is to construct a multilevel mixed linear model for panel data by estimating parameters and testing the hypothesis of fit of the model with case studies in determining the prediction of the health index for the marginal and conditional models on the factors that influence the prediction of the health index in West Java for 2016 data. -2021, with time (year) and region (district and city) variables as factors involved in the model. Multilevel mixed linear model is the development of a mixed linear model that can be used to analyze correlated panel data. Parameter estimation uses the Maximum Likelihood (ML) method to estimate fixed effect parameters and Restricted Maximum Likelihood (REML) to estimate covariance parameters. The results obtained by the health index prediction model in West Java, both for the marginal and conditional prediction models and goodness of fit model.
Dinamika Usaha Perikanan Masyarakat Suku Akit di Kepulauan Riau
Authors: Elsera Marisa , Wisadirana Darsono , Edi Kuswandoro Wawan , Fatma Chawa Anif , Casiavera Casiavera , Oprasmani3 Elfa 
Published: July 2024

Makalah ini bertujuan untuk mendeskripsikan dinamika permasalahan pada usaha penangkapan perikanan dan usaha budi daya perikanan pada masyarakat Suku Akit yang merupakan salah satu dari komunitas adat terpencil (KAT) di Indonesia. Suku Akit belajar melakukan budi daya ketam (kepiting bakau/Scylla) dan siput bakau (Siput mangrove/Telescopium Telescopium) secara otodidak dan mengalami kegagalan. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Penelitian dilakukan pada tahun 2020-2021 dan pengolahan data dilakukan pada tahun 2022. Hasil penelitian menunjukkan bahwa ada dua golongan masalah masyarakat Suku Laut, pertama dalam hal penangkapan mereka hanya bisa melakukan penangkapan dengan menggunakan alat-alat tradisional dengan risiko lingkungan lebih kecil namun hasil tangkapan juga sangat sedikit. Kedua, mereka mengalami kendala pengetahuan, akses dan kurangnya pendampingan pada perikanan budi daya. Pada usaha budi daya kepiting bakau, mereka masih mengalami beberapa kendala, yaitu pertama, Suku Akit belum memahami tingkah laku kanibalisme ketam yang dibudi dayakan, sehingga ketam dewasa dengan anak ketamdigabungkan dalam satu kolamketambudi daya. Kedua, Suku Akit membuat kolam budi daya ketam yang lebih rendah, sehinggapada saat air pasang ketam yang dibudi dayakan hanyut karena arus pasang surut. Ketiga, mereka tidak dilakukan pengecekan kualitas air pada lingkungan budi daya secara berkala Title: The Dynamics of Problems of Akit Ethnic Community in Riau IslandsThis paper aims to describe the dynamics of fishing and aquaculture businesses in the Akit community, which is one of the remote indigenous communities (KAT) in Indonesia. The Akit learnt to cultivate mangrove crabs (Scylla) and mangrove snails (Telescopium) by themselves and experienced failure. This research uses a qualitative method with a descriptive approach. The research was conducted in 2020-2021 and data processing was carried out in 2022. Based on the results of the research, two classes of problems of the Sea Tribe community can be identified, firstly in terms of fishing they can only catch using traditional tools with less environmental risk but the catch is also very small. Secondly, there is the issue of aquaculture, where they experience constraints in knowledge, access and lack of assistance. The weaknesses in the Akit Tribe's fisheries efforts are First, the Akit Tribe combines adult oysters with juvenile oysters because they do not understand the cannibalistic behaviour of the cultivated oysters. Secondly, the Akit Tribe made a lower oyster cultivation pond at high tide so that the cultivated oysters were washed away by the tidal current. Third, there is no regular checking of water quality in the cultivation environment
Association Analysis of Polymorphism rs386000 of the LILRA3 Gene and the Risk of Atherosclerosis Obliterans: a Pilot Study
Authors: Zhabin S. N. , Lazarenko V. A. , Azarova Yu. E. , Bashkatov D. A. , Klyosova E. Yu. , Gneeva E. G. , Churnosov M. I. , Polonikov A. V. 
Published: July 2024

Aim. To study the association of the rs386000 polymorphic variant in the LILRA3 gene with the risk of developing obliterating atherosclerosis of the lower extremity arteries (OALEA).Material and methods. 1277 individuals of Slavic origin were examined (629 patients with OALEA and 648 healthy volunteers). Genotyping of the LILRA3 gene rs386000 was performed with a MassARRAY-4 genomic mass spectrometer. Polymorphic variants of the LILRA3 gene, that encodes the leukocyte immunoglobulin-like receptor A3, may be attractive objects for studying the mechanisms of atherosclerosis.Results. The study showed that the rs386000 polymorphic variant in the LILRA3 gene was associated with the risk of developing OALEA. However, this association was characterized by sexual dimorphism: in men, carriage of the rs386000-C allele (p=0.03) and the rs386000-C/C genotype (p=0.01) was protective against the risk of developing OALEA, while in women, this polymorphism did not influence the susceptibility to the disease. Single nucleotide polymorphism (SNP) annotation showed that carriage of the rs386000‑C allele was associated with an increased expression of the LILRA2, LILRB5, LILRA6, LILRP1 and TSEN34 genes and a decreased expression of the LILRA3 and LILRA5 genes in the blood.Conclusion. The present study revealed for the first time an association of the rs386000‑C allele of the LILRA3 gene with a reduced risk of developing OALEA. Further studies, including experimental studies, will determine the specific mechanisms mediating the involvement of the LILRA3 gene rs386000 polymorphism in the molecular mechanisms for the development of obliterating atherosclerosis, as well as the nature of the sex-specific association of the polymorphism.