bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recessive
MYH6
Mutations in Hypoplastic Left Heart With Reduced Ejection Fraction
Authors: Theis Jeanne L. , Zimmermann Michael T. , Evans Jared M. , Eckloff Bruce W. , Wieben Eric D. , Qureshi Muhammad Y. , O’Leary Patrick W. , Olson Timothy M. 
Published: June 2015

Background—
The molecular underpinnings of hypoplastic left heart are poorly understood. Staged surgical palliation has dramatically improved survival, yet eventual failure of the systemic right ventricle necessitates cardiac transplantation in a subset of patients. We sought to identify genetic determinants of hypoplastic left heart with latent right ventricular dysfunction in individuals with a Fontan circulation.

Methods and Results—

Evaluation of cardiac structure and function by echocardiography in patients with hypoplastic left heart and their first-degree relatives identified 5 individuals with right ventricular ejection fraction ≤40% after Fontan operation. Whole genome sequencing was performed on DNA from 21 family members, filtering for genetic variants with allele frequency <1% predicted to alter protein structure or expression. Secondary family-based filtering for de novo and recessive variants revealed rare inherited missense mutations on both paternal and maternal alleles of
MYH6
, encoding myosin heavy chain 6, in 2 patients who developed right ventricular dysfunction 3 to 11 years postoperatively. Parents and siblings who were heterozygous carriers had normal echocardiograms. Protein modeling of the 4 highly conserved amino acid substitutions, residing in both head and tail domains, predicted perturbation of protein structure and function.

Conclusions—

In contrast to dominant
MYH6
mutations with variable penetrance identified in other congenital heart defects and dilated cardiomyopathy, this study reveals compound heterozygosity for recessive
MYH6
mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction. These findings implicate a shared molecular basis for the developmental arrest and latent myopathy of left and right ventricles, respectively.
Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women
Authors: Marklund Matti , Leander Karin , Vikström Max , Laguzzi Federica , Gigante Bruna , Sjögren Per , Cederholm Tommy , de Faire Ulf , Hellénius Mai-Lis , Risérus Ulf 
Published: June 2015

Background—
High intake of polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular disease (CVD) and mortality. Large, prospective studies including both sexes and circulating PUFAs as dietary biomarkers are needed. We investigated sex-specific associations of the major dietary PUFAs, eicosapentaenoic acid, docohexaenoic acid, linoleic acid, and α-linolenic acid, with incident CVD and all-cause mortality in a population-based cohort.

Methods and Results—
PUFAs in serum cholesterol esters were measured at baseline in 60-year-old Swedish women (n=2193) and men (n=2039). With the use of national registers, 484 incident CVD events (294 men and 190 women) and 456 all-cause deaths (265 men and 191 women) were identified during follow-up (median, 14.5 years) in individuals without prior CVD at baseline. Associations of PUFAs with CVD and mortality were evaluated with Cox proportional hazard models. In multivariable-adjusted models, 1-SD increases in eicosapentaenoic acid and docohexaenoic acid were associated with lower risk of incident CVD among women (hazard ratio [HR], 0.79 [95% confidence interval (CI), 0.64–0.97] and 0.74 [95% CI, 0.61–0.89], respectively). α-Linolenic acid was associated with moderately increased CVD risk in women (HR, 1.16; 95% CI, 1.02–1.32). Inverse associations with all-cause mortality were observed for eicosapentaenoic acid and docohexaenoic acid among all participants (HR, 0.81 [95% CI, 0.72–0.91] and 0.80 [95% CI, 0.72–0.89], respectively) and for linoleic acid in men (HR, 0.73; 95% CI, 0.64–0.83).

Conclusions—
Serum linoleic acid and very-long-chain n-3 PUFAs, partly reflecting vegetable oil and fish intake, respectively, were inversely associated with all-cause mortality. Inverse associations of eicosapentaenoic acid and docohexaenoic acid with incident CVD were observed only in women.
Azo reactive dyes: ultrafiltration and application to cotton by exhaustion and digital ink-jet printing
Authors: Lykidou Smaro , Karanikas Evangelos , Nikolaidis Nikolaos , Tsatsaroni Eforia 
Published: June 2015

Three reactive dyes have been synthesized by coupling 1-amino-phenyl-4-beta hydroxyethyl sulfone sulfate ester with 1-amino-8-hydroxynaphalene-3,6-disoulphonic acid (H-acid). The dyes synthesized were then purified using ultrafiltration and water-based reactive ink jet inks were prepared for digital printing applications. The dyes were characterized by their spectrophotometrical data ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy, optical emission spectroscopy, X-ray diffraction and elemental analysis. The purity of dyes was checked by thin layer chromatography and their dyeing performance was assessed on cotton fibers by exhaustion (dyeing) and ink-jet printing. Ink-jet inks with the dyes synthesized were prepared and their physical properties were measured in order to evaluate their suitability for ink-jet printing. Color measurements and fastness properties were performed for the dyed and digitally printed samples. Coloristic values of the dyed/ printed samples were as expected, that is, K/ S values of the dyed samples were much higher than those of the printed ones, K/ S values of the samples dyed with the ultrafiltrated dyes were higher than those with the initial dyes and the rest of the coloristic co-ordinates L, a, b, C, H, were in line with strength changes of the dyes before and after ultrafiltration. The dyed samples had excellent wash fastness and medium light fastness. Ultrafiltration slightly improves the fastness properties of the dyed samples.
Determinants of Single and Multiple Sensory Impairments in an Urban Population
Authors: Khil Laura , Wellmann Jürgen , Berger Klaus 
Published: June 2015

ObjectiveTo describe the co‐occurrence pattern and determinants of auditory, olfactory, visual, and gustatory impairment across the life spectrum of adults.Study DesignCross‐sectional analysis.SettingAn urban population.Subjects and MethodIn total, 1208 persons from the general adult population (age range, 25‐74 years; 46.7% men) were included. Sensory impairments were assessed with validated tests. Alternating logistic regression was applied to characterize (1) the dependence of sensory impairments on selected independent variables and (2) the pairwise association between sensory impairments. The dependence of impairment grade (no to multisensory impairment) on the same set of independent variables was examined using ordinal logistic regression.ResultsThe prevalence of single sensory impairment was 38.8%, of dual 27.3%, and of multisensory impairment 7.5%. Auditory impairment was the most frequent impairment type (43.9%), followed by olfactory (21.5%), gustatory (20.3%), and visual impairment (14.1%). Besides age and sex, social status (odds ratio [OR], 2.61; 95% confidence interval [CI], 1.80‐3.79), smoking status (OR, 1.45; 95% CI, 1.12‐1.88), and diabetes (OR, 1.75; 95% CI, 1.16‐2.63) were related to an elevated odds of moving from a lower into a higher impairment category.ConclusionsThe presence of certain risk factors, such as a low social status, diabetes, and smoking, appears likely to increase the risk of multisensory impairment.
Massively Parallel Sequencing for Genetic Diagnosis of Hearing Loss
Authors: Shearer A. Eliot , Smith Richard J. H. 
Published: June 2015

ObjectiveTo evaluate the use of new genetic sequencing techniques for comprehensive genetic testing for hearing loss.Data SourcesArticles were identified from PubMed and Google Scholar databases using pertinent search terms.Review MethodsLiterature search identified 30 studies as candidates that met search criteria. Three studies were excluded, and 8 studies were found to be case reports. Twenty studies were included for review analysis, including 7 studies that evaluated controls and 16 studies that evaluated patients with unknown causes of hearing loss; 3 studies evaluated both controls and patients.ConclusionsIn the 20 studies included in the review analysis, 426 control samples and 603 patients with unknown causes of hearing loss underwent comprehensive genetic diagnosis for hearing loss using massively parallel sequencing. Control analysis showed a sensitivity and specificity >99%, sufficient for clinical use of these tests. The overall diagnostic rate was 41% (range, 10%‐83%) and varied based on several factors, including inheritance and prescreening prior to comprehensive testing. There were significant differences in platforms available with regard to the number and type of genes included and whether copy number variations were examined. Based on these results, comprehensive genetic testing should form the cornerstone of a tiered approach to clinical evaluation of patients with hearing loss along with history, physical examination, and audiometry and can determine further testing that may be required, if any.Implications for PracticeComprehensive genetic testing has become the new standard of care for genetic testing for patients with sensorineural hearing loss.
Preclinical Evaluation of Poly(HEMA-co-acrylamide) Hydrogels Encapsulating Glucose Oxidase and Palladium Benzoporphyrin as Fully Implantable Glucose Sensors
Authors: Unruh Rachel M. , Roberts Jason R. , Nichols Scott P. , Gamsey Soya , Wisniewski Natalie A. , McShane Michael J. 
Published: June 2015

Background: Continuous glucose monitors (CGMs) require percutaneous wire probes to monitor glucose. Sensors based on luminescent hydrogels are being explored as fully implantable alternatives to traditional CGMs. Our previous work investigated hydrogel matrices functionalized with enzymes and oxygen-quenched phosphors, demonstrating sensitivity to glucose, range of response, and biofouling strongly depend on the matrix material. Here, we further investigate the effect of matrix composition on overall performance in vitro and in vivo. Methods: Sensors based on three hydrogels, a poly(2-hydroxyethyl methacrylate) (pHEMA) homopolymer and 2 poly(2-hydroxyethyl methacrylate-co-acrylamide) (pHEMA-co-AAm) copolymers, were compared. These were used to entrap glucose oxidase (GOx), catalase, and an oxygen-sensitive benzoporphyrin phosphor. All sensor formulations were evaluated for glucose response and stability at physiological temperatures. Selected sensors were then evaluated as implanted sensors in a porcine model challenged with glucose and insulin. The animal protocol used in this study was approved by an IACUC committee at Texas A&M University. Results: PHEMA-co-AAm copolymer hydrogels (75:25 HEMA:AAm) yielded the most even GOx and dye dispersion throughout the hydrogel matrix and best preserved GOx apparent activity. In response to in vitro glucose challenges, this formulation exhibited a dynamic range of 12-167 mg/dL, a sensitivity of 1.44 ± 0.46 µs/(mg/dL), and tracked closely with reference capillary blood glucose values in vivo. Conclusions: The hydrogel-based sensors exhibited excellent sensitivity and sufficiently rapid response to the glucose levels achieved in vivo, proving feasibility of these materials for use in real-time glucose tracking. Extending the dynamic range and assessing long-term effects in vivo are ongoing efforts.
Splanchnic venous thrombosis is a marker of cancer and a prognostic factor for cancer survival
Authors: Søgaard Kirstine K. , Farkas Dóra K. , Pedersen Lars , Sørensen Henrik T. 
Published: June 2015

Key Points
SVT is a marker of occult cancer, in particular myeloproliferative neoplasms, liver cancer, and pancreatic cancer. SVT is a prognostic factor for short-term survival in patients diagnosed with liver or pancreatic cancer.
The general traveling wave solutions of the Fisher type equations and some related problems
Authors: Yuan Wenjun , Xiao Bing , Wu Yonghong , Qi Jianming 
Published: June 2015

Abstract
In this article, we introduce two recent results with respect to the integrality and exact solutions of the Fisher type equations and their applications. We obtain the sufficient and necessary conditions of integrable and general meromorphic solutions of these equations by the complex method. Our results are of the corresponding improvements obtained by many authors. All traveling wave exact solutions of many nonlinear partial differential equations are obtained by making use of our results. Our results show that the complex method provides a powerful mathematical tool for solving a great number of nonlinear partial differential equations in mathematical physics. We will propose four analogue problems and expect that the answer is positive, at last.

MSC:30D35, 34A05.
Existence of a common solution of an integral equations system by "Equation missing" -weakly contractions
Authors: Lo’lo’ Parvaneh , Vaezpour Seiyed Mansour , Saadati Reza , Park Choonkil 
Published: June 2015

Abstract
In this paper, we consider a system of integral equations and apply the coincidence and common fixed point theorems for four mappings satisfying a

(
ψ
,
α
,
β
)

-weakly contractive condition in ordered metric spaces to prove the existence of a common solution to integral equations. Also we furnish suitable examples to demonstrate the validity of the hypotheses of our results.

MSC:54H25, 47H10.
Psychometric properties of the stagnation scale in medication overuse headache patients
Authors: Innamorati Marco , Pompili Maurizio , Erbuto Denise , Ricci Federica , Migliorati Monica , Lamis Dorian A , Amore Mario , Girardi Paolo , Martelletti Paolo 
Published: June 2015

Abstract

Background
Medication-overuse headache (MOH) is often comorbid with emotional disturbances, contributing to poorer outcomes. The aims of the present study were to assess the psychometric properties of the Stagnation Scale in a sample of MOH patients, and to compare two factor models: a three-factor model reported in previous studies and a proposed bi-factor model.

Methods
Consecutive adult outpatients (N = 310) admitted to the Regional Referral Headache Centre of the Sant’Andrea Hospital in Rome (Italy) were administered the Stagnation Scale and two questionnaires measuring depression and perceived disability.

Results
The original three-factor model demonstrated an adequate fit to the data (χ

2

101 = 238.70; p < 0.001; Root Mean Square Error of Approximation [RMSEA] = 0.07; 90% CI of RMSEA = 0.06 / 0.08; Comparative Fit Index [CFI] = 0.98; Weighted Root Mean Square Residual [WRMR] = 0.75). However, the bi-factor model had a comparable or even better fit, with a RMSEA of 0.05 (90% CI: 0.04 / 0.07), providing strong evidence for an absolute fit to the data (χ

2

88 = 161.43; p < 0.001; RMSEA = 0.05; 90% CI of RMSEA = 0.04 / 0.07; CFI = 0.99; WRMR = 0.56). The stagnation general factor and all the group factors correlated significantly and positively with convergent measures.

Conclusions
There is support for the use of the Stagnation Scale in MOH patients, with the goal of better understanding the role of psychological factors in the evolution and course of the disorder.
Cervicogenic headache: too important to be left un-diagnosed
Authors: Fredriksen Torbjørn A , Antonaci Fabio , Sjaastad Ottar 
Published: June 2015

Abstract
A comparison has been made between the cervicogenic headache criteria in the new IHS classification of headaches (3rd edition- beta version) and The Cervicogenic Headache International Study Group’s (GHISG) criteria from 1998. In a more recent version, the CHISG criteria consist of 7 different items. While “core cases” of cervicogenic headache (CEH) usually fulfill all 7 criteria, the IHS classification - 3rd edition beta version- fulfills only 3 criteria. Although the new three beta version represents an improvement from the previous one, it does not quite seem to live up to the expectations for a diagnostic system for routine, clinical use.
Propargylic substitution reactions with various nucleophilic compounds using efficient and recyclable mesoporous silica spheres embedded with FeCo/graphitic shell nanocrystals
Authors: Jang Seongwan , Kim A Young , Seo Won Seok , Park Kang Hyun 
Published: June 2015

Abstract
Phosphomolybdic acid (PMA, H3PMo12O40) functioned as a catalyst for reactions of secondary propargylic alcohols and nucleophiles. Highly stable and magnetically recyclable mesoporous silica spheres (MMS) embedded with FeCo-graphitic carbon shell nanocrystals (FeCo/GC@MSS) were fabricated by a modified Stöber process and chemical vapor deposition (CVD) method. The FeCo/GC@MSS were loaded with phosphomolybdic acid (PMA@FeCo/GC@MSS), and their catalytic activity was investigated. Propargylic reactions of 1,3-diphenyl-2-propyn-1-ol with a wide range of nucleophiles bearing activating substituents were catalyzed under mild conditions. It was found that the MMS possess mesoporosities and have enough inner space to load FeCo and phosphomolybdic acid. The FeCo/GC@MSS were found to be chemically stable against acid etching and oxidation. This suggests that the nanocrystals can be used as a support for an acid catalyst. Moreover, the magnetic property of the nanocrystals enabled the facile separation of catalysts from the products.
Galvanic synthesis of three-dimensional and hollow metallic nanostructures
Authors: Park Sun Hwa , Son Jin Gyeong , Lee Tae Geol , Kim Jongwon , Han Sang Yun , Park Hyun Min , Song Jae Yong 
Published: June 2015

Abstract
We report a low-cost, facile, and template-free electrochemical method of synthesizing three-dimensional (3D) hollow metallic nanostructures. The 3D nanoporous gold (3D-NPG) nanostructures were synthesized by a galvanic replacement reaction (GRR) using the different reduction potentials of silver and gold; hemispherical silver nanoislands were electrochemically deposited on cathodic substrates by a reverse-pulse potentiodynamic method without templates and then nanoporous gold layer replicated the shape of silver islands during the GRR process in an ultra-dilute electrolyte of gold(III) chloride trihydrate. Finally, the wet etching process of remaining silver resulted in the formation of 3D-NPG. During the GRR process, the application of bias voltage to the cathode decreased the porosity of 3D-NPG in the voltage range of 0.2 to -0.62 V. And the GRR process of silver nanoislands was also applicable to fabrication of the 3D hollow nanostructures of platinum and palladium. The 3D-NPG nanostructures were found to effectively enhance the SERS sensitivity of rhodamine 6G (R6G) molecules with a concentration up to 10-8 M.
RRAM characteristics using a new Cr/GdOx/TiN structure
Authors: Jana Debanjan , Dutta Mrinmoy , Samanta Subhranu , Maikap Siddheswar 
Published: June 2015

Abstract
Resistive random access memory (RRAM) characteristics using a new Cr/GdOx/TiN structure with different device sizes ranging from 0.4 × 0.4 to 8 × 8 μm2 have been reported in this study. Polycrystalline GdOx film with a thickness of 17 nm and a small via-hole size of 0.4 μm are observed by a transmission electron microscope (TEM) image. All elements and GdOx film are confirmed by energy dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy analyses. Repeatable resistive switching characteristics at a current compliance (CC) of 300 μA and low operating voltage of ±4 V are observed. The switching mechanism is based on the oxygen vacancy filament formation/rupture through GdOx grain boundaries under external bias. After measuring 50 RRAM devices randomly, the 8-μm devices exhibit superior resistive switching characteristics than those of the 0.4-μm devices owing to higher recombination rate of oxygen with remaining conducting filament in the GdOx film as well as larger interface area, even with a thinner GdOx film of 9 nm. The GdOx film thickness dependence RRAM characteristics have been discussed also. Memory device shows repeatable 100 switching cycles, good device-to-device uniformity with a switching yield of approximately 80%, long read endurance of >105 cycles, and good data retention of >3 × 104 s at a CC of 300 μA.
Electric field enhancement and far-field radiation pattern of the nanoantenna with concentric rings
Authors: Chen Shih-Wen , Huang Yi-Han , Chao Bo-Kai , Hsueh Chun-Hway , Li Jia-Han 
Published: June 2015

Abstract
The optical antennas have the potential in various applications because of their field enhancement and directivity control. The directivity of a dipole antenna can be improved by directivity-enhanced Raman scattering structure, which is a combination of a dipole antenna and a ring reflector layer on a ground plane. The concentric rings can collect the light into the center hole. Depending upon the geometry of the antenna inside the hole, different electric field enhancements can be achieved. In this paper, we propose to combine the concentric rings with the directivity-enhanced Raman scattering structure in order to study its electric field enhancement and the far-field radiation pattern by finite-difference time-domain simulations. Compared with the structure without the concentric rings over the ground plane, it is found that our proposed structure can obtain stronger electric field enhancements and narrower radiation beams because the gold rings can help to couple the light into the nanoantenna and they also scatter light into the far field and modify the far-field radiation pattern. The designed structures were fabricated and the chemical molecules of thiophenol were attached on the structures for surface-enhanced Raman scattering (SERS) measurements. The measured results show that the structure with concentric rings can have stronger SERS signals. The effects of the dielectric layer thickness in our proposed structure on the near-field enhancements and far-field radiation are also investigated. The proposed structure can be useful for several nanoantenna applications, such as sensing or detecting.
Evaluation of self-assembled HCPT-loaded PEG-b-PLA nanoparticles by comparing with HCPT-loaded PLA nanoparticles
Authors: Yang Xiangrui , Wu Shichao , Wang Yange , Li Yang , Chang Di , Luo Yin , Ye Shefang , Hou Zhenqing 
Published: June 2015

Abstract
We present a dialysis technique to prepare the 10-hydroxycamptothecin (HCPT)-loaded nanoparticles (NPs) using methoxypolyethylene glycol-poly(d,l-lactide) (PEG-b-PLA) and PLA, respectively. Both HCPT-loaded PEG-b-PLA NPs and HCPT-loaded PLA NPs were characterized by differential scanning calorimetry (DSC), dynamic light scattering (DLS), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The results showed that the HCPT-loaded PEG-b-PLA NPs and HCPT-loaded PLA NPs presented a hydrodynamic particle size of 120.1 and 226.8 nm, with a polydispersity index of 0.057 and 0.207, a zeta potential of −31.2 and −45.7 mV, drug encapsulation efficiency of 44.52% and 44.94%, and drug-loaded content of 7.42% and 7.49%, respectively. The HCPT-loaded PEG-b-PLA NPs presented faster drug release rate compared to the HCPT-loaded PLA NPs. The HCPT-loaded PEG-b-PLA NPs presented higher cytotoxicity than the HCPT-loaded PLA NPs. These results suggested that the HCPT-loaded PEG-b-PLA NPs presented better characteristics for drug delivery compared to HCPT-loaded PLA NPs.