bluuebunny/crossref_metadata_2025_split huggingface dataset:
Itaconate and dimethyl itaconate upregulate IL-6 production in the LPS-induced inflammation in mice
Authors: Nosenko Maxim , Anisov Denis , Gubernatorova Ekaterina , Gorshkova Ekaterina , Zeng Yi-Rong , Ye Dan , Wang Pu , Finlay David , Drutskaya Marina , Nedospasov Sergei 
Published: June 2024

Abstract
Itaconate is one of the most studied immunometabolites produced by myeloid cells during inflammatory response. It mediates a wide range of anti-inflammatory and immunoregulatory effects and plays a role in a number of pathological states, including autoimmunity and cancer. Itaconate and its derivatives are considered potential therapeutic agents for the treatment of inflammatory diseases. While immunoregulatory effects of itaconate have been extensively studied in vitro and using knockout mouse models, less is known about how therapeutic administration of this metabolite regulates inflammatory response in vivo. Here, we investigate the immunoregulatory properties of exogenous administration of itaconate and its derivative dimethyl itaconate in a mouse model of lipopolysaccharide-induced inflammation. The data show that administration of itaconate or dimethyl itaconate controls systemic production of multiple cytokines, including increased IL-10 production. However, only dimethyl itaconate was able to suppress systemic production of IFNγ and IL-1β. In contrast to in vitro data, administration of itaconate or dimethyl itaconate in vivo resulted in systemic upregulation of IL-6 in the blood. Electrophilic stress due to itaconate or dimethyl itaconate was not responsible for IL-6 upregulation. However, inhibition of succinate dehydrogenase with dimethyl malonate also resulted in elevated systemic levels of IL-6 and IL-10. Taken together, our study reports a novel effect of exogenous itaconate and its derivative dimethyl itaconate on the production of IL-6 in vivo, with important implications for the development of itaconate-based anti-inflammatory therapies.
Activity responses of a mammal community to a 17-year cicada emergence event
Authors: Proudman Alexis S , Jones Landon R , Watkins Morgan O , Flaherty Elizabeth A 
Published: June 2024

Abstract
During a limited period in the summer of 2021, 17-year cicada species (Magicicada cassini, M. septendecula, M. septendecim) represented a large pulse of easily accessible food unique to forest ecosystems in the eastern United States. Using trail cameras and acoustic recorders, we tested whether the activity levels of 8 mammal species in northwestern Indiana shifted in response to spatial and temporal variation in cicada densities from 18 May to 20 June 2021. Cicada densities varied temporally and spatially across all study sites. Most mammal species with sufficient data showed no response to cicada emergence, including 2 tree squirrel species, Peromyscus mice, Eastern Chipmunks (Tamias striatus), and 2 species of bats. Raccoons (Procyon lotor), likely cicada predators, showed a quadratic or more complex activity response to cicada abundance, indicating a potential saturation point at densities near 1 cicada per m2. Surprisingly, White-tailed Deer (Odocoileus virginianus) activity decreased to almost 0 at the same cicada densities when we expected no change in activity. While size or accessibility may exclude cicadas as prey for small and volant mammals, our results suggest predation and satiation by Raccoons. In contrast, deer may be avoiding areas of cicada abundance due to other stimuli, such as high noise output, which may decrease their ability to detect predators.
Coyote use of prairie dog colonies is most frequent in areas used by American badgers
Authors: Windell Rebecca M , Bailey Larissa L , Livieri Travis M , Eads David A , Biggins Dean E , Breck Stewart W 
Published: June 2024

Abstract
The consequences of intraguild predation on vulnerable subordinate species are an important consideration in the recovery of endangered species. In prairie ecosystems, coyotes (Canis latrans) are the primary predator of endangered black-footed ferrets (Mustela nigripes; hereafter, ferrets) and presumably compete for prairie dog (Cynomys spp.) prey. Coyote predation of ferrets is thought to occur at night when ferrets are active aboveground; however, the apparent source of competition, diurnal prairie dogs, are belowground and inaccessible to coyotes at this time, presenting a perplexing temporal mismatch between actual and expected times that coyotes and ferrets come into conflict. Our study used remote wildlife cameras, occupancy models, and overlap of circadian activity patterns to investigate how landscape features, prairie dog colony attributes, and attraction to sympatric species, i.e., American badgers (Taxidea taxus; hereafter, badgers) and lagomorphs (cottontail rabbits and jackrabbits) influence Coyote use of prairie dog colonies and potential Coyote–ferret interactions. We first evaluated Coyote use (i.e., occupancy) between prairie dog colonies and surrounding available grasslands, finding that coyotes whose home ranges include prairie dog colonies used colonies nearly twice as much as surrounding grasslands. Next, we investigated biotic and abiotic factors that may influence Coyote use and frequency of use (i.e., detection probability) on prairie dog colonies. We found high Coyote use across all areas on prairie dog colonies; however, their frequency of use increased in areas that were also used by badgers. High overlap between Coyote and badger activity patterns (81%) further supports the spatial use patterns revealed by our occupancy analysis, and badgers and coyotes are known to form hunting associations. Interspecific competition and overlapping patterns of resource use between badgers and ferrets have been documented in previous studies; our study supports these findings and suggests that Coyote attraction to badger activity may influence Coyote–ferret interactions.
Scalar field dark matter: impact of supernova-driven blowouts on the soliton structure of low-mass dark matter haloes
Authors: Robles Victor H , Zagorac J Luna , Padmanabhan Nikhil 
Published: June 2024

ABSTRACT
We present the first study on the gravitational impact of supernova feedback in an isolated soliton and a spherically symmetric dwarf scalar field dark matter (SFDM) halo of virial mass $1\times 10^{10}\,\mathrm{M_\odot }$. We use a boson mass $m=10^{-22}\,\mathrm{eV\,c^{-2}}$ and a soliton core $r_\mathrm{ c} \approx 0.7$ kpc, comparable to typical half-light radii of Local Group dwarf galaxies. We simulate the rapid gas removal from the centre of the soliton by a concentric external time-dependent Hernquist potential. We explore two scenarios of feedback blowouts: (i) a massive single burst and (ii) multiple consecutive blowouts injecting the same total energy to the system, including various magnitudes for the blowouts in both scenarios. In all cases, we find one single blowout has a stronger effect on reducing the soliton central density. Feedback leads to central soliton densities that oscillate quasi-periodically for an isolated soliton and stochastically for an SFDM halo. The range in the density amplitude depends on the strength of the blowout; however, we observe typical variations of a factor of $\geqslant$2. One important consequence of the stochastic fluctuating densities is that, if we had no prior knowledge of the system evolution, we can only know the configuration profile at a specific time within some accuracy. By fitting soliton profiles at different times to our simulated structures, we found the (1$\sigma$) scatter of their time-dependent density profiles. For configurations within the 1$\sigma$ range, we find the inferred boson mass is typically less than 20 per cent different from the real value used in our simulations. Finally, we compare the observed dynamical masses of field dwarf galaxies in our Local Group with the implied range of viable solitons from our simulations and find good agreement.
The stellar fundamental metallicity relation: the correlation between stellar mass, star formation rate, and stellar metallicity
Authors: Looser Tobias J , D’Eugenio Francesco , Piotrowska Joanna M , Belfiore Francesco , Maiolino Roberto , Cappellari Michele , Baker William M , Tacchella Sandro 
Published: June 2024

ABSTRACT
We present observational evidence for a stellar fundamental metallicity relation (FMR), a smooth relation between stellar mass, star formation rate, and the light-weighted stellar metallicity of galaxies, analogous to the well-established gas-phase FMR. We use the non-parametric software ppxf to reconstruct simultaneously the star formation and chemical-enrichment history of a representative sample of galaxies from the local MaNGA (Mapping Nearby Galaxies at Apache Point Observatory) survey. We find that (i) the metallicity of individual galaxies increases with cosmic time and (ii) at all stellar masses, the metallicity of galaxies is progressively higher, moving from the starburst region above the main sequence (MS) towards the passive galaxies below the MS, manifesting the stellar FMR. The scatter is reduced when replacing the stellar mass $M_{*}$ with $M_{*}/R_{\rm e}$ (with $R_{\rm e}$ being the effective radius), in agreement with previous results using the velocity dispersion $\sigma _{\rm e}$, which correlates with $M_{*}/R_{\rm e}$. Our results point to starvation as the main physical process through which galaxies quench, showing that metal-poor gas accretion from the intergalactic medium/circumgalactic medium – or the lack thereof – plays an important role in galaxy evolution by simultaneously shaping both their star formation and their metallicity evolutions, while outflows play a subordinate role. This interpretation is further supported by the additional finding of a young stellar FMR, tracing only the stellar populations formed in the last 300 Myr. This suggests a tight co-evolution of the chemical composition of both the gaseous interstellar medium and the stellar populations, where the gas-phase FMR is continuously imprinted on to the stars over cosmic times.
A model for galaxy–galaxy strong lensing statistics in surveys
Authors: Ferrami G , Wyithe J Stuart B 
Published: June 2024

ABSTRACT
Photometric wide-area observations in the next decade will be capable of detecting a large number of galaxy-scale strong gravitational lenses, increasing the gravitational lens sample size by orders of magnitude. To aid in forecasting and analysis of these surveys, we construct a flexible model based on observed distributions for the lens and source properties and test it on the results of past lens searches, including SL2S, SuGOHI, and searches on the COSMOS HST and DES fields. We use this model to estimate the expected yields of some current and planned surveys, including Euclid Wide, Vera Rubin LSST, and Roman High Latitude Wide Area. The model proposed includes a set of free parameters to constrain on the identifiability of a lens in an image, allowing construction of prior probability distributions for different lens detection methods. The code used in this work is made publicly available.
Safety, efficacy, and survival outcomes of immune checkpoint inhibitors rechallenge in patients with cancer: a systematic review and meta-analysis
Authors: Liu Shi-Jia , Yan Lun-Jie , Wang Han-Chao , Ding Zi-Niu , Liu Hui , Zhang Xiao , Pan Guo-Qiang , Han Cheng-Long , Tian Bao-Wen , Yang Xiao-Rong , Tan Si-Yu , Dong Zhao-Ru , Wang Dong-Xu , Yan Yu-Chuan , Li Tao 
Published: June 2024

Abstract

Backgrounds
There is little evidence on the safety, efficacy, and survival benefit of restarting immune checkpoint inhibitors (ICI) in patients with cancer after discontinuation due to immune-related adverse events (irAEs) or progressive disease (PD). Here, we performed a meta-analysis to elucidate the possible benefits of ICI rechallenge in patients with cancer.

Methods
Systematic searches were conducted using PubMed, Embase, and Cochrane Library databases. The objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and incidence of irAEs were the outcomes of interest.

Results
Thirty-six studies involving 2026 patients were analyzed. ICI rechallenge was associated with a lower incidence of all-grade (OR, 0.05; 95%CI, 0.02-0.13, P &lt; .05) and high-grade irAEs (OR, 0.37; 95%CI, 0.21-0.64, P &lt; .05) when compared with initial ICI treatment. Though no significant difference was observed between rechallenge and initial treatment regarding ORR (OR, 0.69; 95%CI, 0.39-1.20, P = .29) and DCR (OR, 0.85; 95%CI, 0.51-1.40, P = 0.52), patients receiving rechallenge had improved PFS (HR, 0.56; 95%CI, 0.43-0.73, P &lt; .05) and OS (HR, 0.55; 95%CI, 0.43-0.72, P &lt; .05) than those who discontinued ICI therapy permanently. Subgroup analysis revealed that for patients who stopped initial ICI treatment because of irAEs, rechallenge showed similar safety and efficacy with initial treatment, while for patients who discontinued ICI treatment due to PD, rechallenge caused a significant increase in the incidence of high-grade irAEs (OR, 4.97; 95%CI, 1.98-12.5, P &lt; .05) and a decrease in ORR (OR, 0.48; 95%CI, 0.24-0.95, P &lt; .05).

Conclusion
ICI rechallenge is generally an active and feasible strategy that is associated with relative safety, similar efficacy, and improved survival outcomes. Rechallenge should be considered individually with circumspection, and randomized controlled trials are required to confirm these findings.
Current status of advance care planning, palliative care consultation, and end-of-life care in patients with glioblastoma in South Korea
Authors: Suh Koung Jin , Jung Eun Hee , Seo Jeongmin , Ji So Young , Hwang Kihwan , Han Jung Ho , Kim Chae-Yong , Kim In Ah , Kim Yu Jung 
Published: June 2024

Abstract

Background
Given the typical trajectory of glioblastoma, many patients lose decision-making capacity over time, which can lead to inadequate advance care planning (ACP) and end-of-life (EOL) care. We aimed to evaluate patients’ current ACP and EOL care status.

Patients and Methods
We conducted a cohort study on 205 patients referred to oncologists at a Korean tertiary hospital between 2017 and 2022. We collected information on sociodemographic factors, cancer treatment, palliative care consultation, ACP, legal documents on life-sustaining treatment (LST) decisions, and aggressiveness of EOL care.

Results
With a median follow-up time of 18.3 months: 159 patients died; median overall survival: 20.3 months. Of the 159 patients, 11 (6.9%) and 63 (39.6%) had advance directive (AD) and LST plans, respectively, whereas 85 (53.5%) had neither. Among the 63 with LST plans, 10 (15.9%) and 53 (84.1%) completed their forms through self-determination and family determination, respectively. Of the 159 patients who died, 102 (64.2%) received palliative care consultation (median time: 44 days from the first consultation to death) and 78 (49.1%) received aggressive EOL care. Those receiving palliative care consultations were less likely to receive aggressive EOL care (83.3% vs 32.4%, P &lt; .001), and more likely to use more than 3 days of hospice care at EOL (19.6% vs 68.0%, P &lt; .001).

Conclusions
The right to self-determination remains poorly protected among patients with glioblastoma, with nearly 90% not self-completing AD or LST plan. As palliative care consultation is associated with less aggressive EOL care and longer use of hospice care, physicians should promptly introduce patients to ACP conversations and palliative care consultations.
Astragalus polysaccharide alleviates IL-13-induced oxidative stress injury in nasal epithelial cells by inhibiting WTAP-mediated FBXW7 m6A modification
Authors: Cui Wei , Jin Zhenglong , Lin Hanyu , Wang Bin , Chen Guojian , Cheng Yongming 
Published: July 2024

Abstract

Background
Allergic rhinitis (AR) a common and complicated upper airway disease mediated by specific IgE antibodies. Our study aims to explore the pharmacological effects of astragalus polysaccharide (APS) on AR and elucidate the mechanisms involved.

Methods
RT-qPCR and Western blotting were used to analyze mRNA and protein expression. Interleukin (IL)-13-treated human nasal epithelial cells (hNECs) was employed as the AR cell model. Cell apoptosis and viability were evaluated by TUNEL staining and MTT assay, respectively. ROS level was examined by the DCFH-DA probe. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels were measured by the corresponding kits. FBXW7 m6A modification level was assessed by MeRIP assay.

Methods
Our results showed that APS treatment reduced cell apoptosis, ROS, and MDA levels while increasing SOD, CAT, and GSH-Px levels in IL-13-treated hNECs by activating the Nrf2/HO-1 pathway. Moreover, APS alleviated IL-13-induced oxidative stress injury in hNECs by downregulating WTAP. In addition, WTAP knockdown increased FBXW7 mRNA stability by regulating FBXW7 mRNA m6A modification. It also turned out that APS alleviated IL-13-induced oxidative stress injury in hNECs through the WTAP/FBXW7 axis.

Conclusions
Taken together, APS inhibited WTAP-mediated FBXW7 m6A modification to alleviate IL-13-induced oxidative stress injury in hNECs.
An update on COPD prevention, diagnosis, and management
Authors: Patel Nisa 
Published: June 2024

ABSTRACT
Chronic obstructive pulmonary disease (COPD) is one of the top three causes of death throughout the world. Because of the preventable and treatable nature of the disease along with its prevalence, COPD represents a major public health challenge. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) Report provides a review of the most current evidence for prevention of COPD as well as the assessment, diagnosis, and treatment of people with the disease. The purpose of this article is to provide a summary of the 2024 revised GOLD Report and current best practices in accordance with the evidence.
Therapeutic management of atopic dermatitis
Authors: Jarrell Lynda 
Published: June 2024

ABSTRACT
Atopic dermatitis (AD), a chronic inflammatory, pruritic skin disorder, is seen primarily in the pediatric population but can be found among all age groups. The symptoms of AD can cause embarrassment in patients and can interrupt daily activities and productivity, potentially resulting in avoidance of social situations. In addition to nonpharmacologic management, mainstay pharmacologic treatments for AD are topical medications including corticosteroids, calcineurin inhibitors, phosphodiesterase-4 inhibitors, and topical Janus kinase (JAK) inhibitors. Promising new drugs—oral JAK inhibitors and monoclonal antibodies—have emerged as new treatment options for moderate-to-severe AD.
Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU
Authors: Tajalli Saleheh , Vafaee Ali , Safi Hamid , Moghaddam Ava Navidi , Fallahi Minoo 
Published: July 2024

Background:
Acquired human cytomegalovirus (CMV) is a noteworthy disease in infants. This case study will highlight the influence of early diagnosis of CMV retinitis (CMVR) on avoid visual impairment.

Clinical Findings:
We describe a preterm female infant with a birth weight of 2060 gr that was admitted for tracheostomy placement due to hypoxic-ischemic encephalopathy. There were no signs of CMV infection or sepsis in laboratory results upon admission such as serology (IgG, IgM antibodies), Toxoplasma gondii, Rubella virus, Herpes simplex virus, CMVR and urine polymerase chain reaction (PCR).

Primary Diagnosis:
Incidentally, upon screening for retinopathy of prematurity, diffuse occlusive vasculitis was detected in the retinal image on the 112th day of life.

Intervention:
Intravenous and intraocular ganciclovir were administered for 4 weeks.

Outcomes:
In the follow-up visit 6 weeks after discharge from the hospital, visual impairment was detected on both sides.

Practice Recommendations:
This is a report of a case of acquired CMVR, a silent finding, as an uncommon complication in preterm neonates during the hospital stay. This diagnosis should be taken into consideration in preterm infants, since early diagnosis and treatment are crucial to avoid visual impairment.
Multimodal data-driven, vertical visualization prediction model for early prediction of atherosclerotic cardiovascular disease in patients with new-onset hypertension
Authors: Wang Jian , Xu Yanan , Zhu Jiajun , Wu Bing , Wang Yijun , Tan Liguo , Tang Long , Wang Jun 
Published: June 2024

Background
: Hypertension is an important contributing factor to atherosclerotic cardiovascular disease (ASCVD), and multiple risk factors, many of which are implicated in metabolic disorders, contribute to the cause of hypertension. Despite the promise of multimodal data-driven prediction model, no such prediction model was available to predict the risk of ASCVD in Chinese individuals with new-onset hypertension and no history of ASCVD.

Methods
: A total of 514 patients were randomly allocated to training and verification cohorts (ratio, 7 : 3). We employed Boruta feature selection and conducted multivariate Cox regression analyses to identify variables associated with ASCVD in these patients, which were subsequently utilized for constructing the predictive model. The performance of prediction model was assessed in terms of discriminatory power (C-index), calibration (calibration curves), and clinical utility [decision curve analysis (DCA)].

Results
: This model was derived from four clinical variables: 24-h SBP coefficient of variation, 24-h DBP coefficient of variation, urea nitrogen and the triglyceride–glucose (TyG) index. Bootstrapping with 500 iterations was conducted to adjust the C-indexes were C-index = 0.731, 95% confidence interval (CI) 0.620–0.794 and C-index: 0.799, 95% CI 0.677–0.892 in the training and verification cohorts, respectively. Calibration plots with 500 bootstrapping iterations exhibited a strong correlation between the predicted and observed occurrences of ASCVD in both the training and verification cohorts. DCA analysis confirmed the clinical utility of this prediction model. The constructed nomogram demonstrated significant additional prognostic utility for ASCVD, as evidenced by improvements in the C-index, net reclassification improvement, integrated discrimination improvement, and DCA compared with the overall ASCVD risk assessment.

Conclusion:
The developed longitudinal prediction model based on multimodal data can effectively predict ASCVD risk in individuals with an initial diagnosis of hypertension.

Trial registration
: The trial was registered in the Chinese Clinical Trial Registry (ChiCTR2300074392).