bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Comparative Study of Anti‐Double Stranded DNA Antibody Levels Measured by Radioimmunoassay and Enzyme‐Linked Immunosorbent Assay in Systemic Lupus Erythematosus
Authors: Takeuchi Yuko , Ishikawa Osamu , Miyachi Yoshiki 
Published: April 2015

AbstractAnti‐double stranded (ds) DNA antibody is an autoantibody specific for systemic lupus erythematosus (SLE). For the measurement of this antibody, radioimmunoassay (RIA) or enzyme‐linked immunosorbent assay (ELISA) is widely used in Japan. We studied the correlation of anti‐dsDNA levels in 158 sera from 53 SLE patients between RIA and ELISA. The correlation coefficient between anti‐dsDNA antibody levels measured by RIA and ELISA was 0.736 (p<0.001). The concordance rate of sera with both ELISA/RIA‐positive or both ELISA/RIA‐negative results was 82.3% (130/158 sera). Twenty sera (12.7%) of 14 patients were ELISA‐positive but RIA‐positive, and 8 sera (5.0%) of 6 patients were ELISA‐negative but RIA‐positive. Our results suggest that both methods may be equally reliable for the detection of anti‐dsDNA antibodies and that ELISA may be more sensitive than RIA. ELISA may be preferable because of its simplicity and convenience of the measurement procedure. The correlation coefficient between anti‐ssDNA levels measured by ELISA and anti‐dsDNA levels measured by RIA was 0.322 (p<0.01), and the correlation coefficient between anti‐ssDNA and anti‐dsDNA antibody levels measured by ELISA was slightly higher, 0.515 (p<0.001). These results may reflect the predominance of anti‐DNA antibodies reactive with both ss and dsDNA in SLE sera. Since the clinical significance of anti‐ssDNA antibodies remains unclear, further analysis of accumulated cases is required.
OK‐432 Therapy for Recalcitrant Warts
Authors: Inui Shigeki , Asada Hideo , Wataya‐Kaneda Mari , Miyamoto Tomoko , Itami Satoshi , Yoshikawa Kunihiko 
Published: April 2015

AbstractTwelve patients with warts recalcitrant to various treatments, including cryotherapy, were treated with OK‐432 injection therapy. Six patients received only subcutaneous injection, three received only intralesional injection, and the other three received both subcutaneous and intralesional injections. Complete clearing of the warts occurred in nine (75%) of 12 patients, while the other three patients were not cured. Grouping the patients by the method of injection, the success rate of subcutaneous injection was 5/9 (55.6%), and that of intralesional injection was 4/6 (66.7%). Although five patients complained of mild fever and malaise, these side effects gradually disappeared during the repeated injections. OK‐432 injection is considered as a hopeful therapy for recalcitrant warts.
A Case of Multiple Nevoid Hypertrichosis
Authors: Chang Sung Nam , Hong Chang Eui , Kim Dong‐Kun , Park Wook Hwa 
Published: April 2015

AbstractNevoid hypertrichosis is an uncommon congenital disorder consisting of terminal hair growth in a localized distribution on flesh‐colored skin; it is not associated with any other systemic abnormalities.A 21‐year‐old male patient had a circumscribed area of depigmented terminal hairs on his chest which had been present since 1 year of age. At the age of 18, similar lesions developed on his left shoulder and upper arm. The underlying skin was slightly hypopigmented, and no other systemic abnormalities were found. Histologic examination demonstrated terminal hair follicles in otherwise normal skin. The number of HMB 45 positive melanocytes was markedly decreased in the affected skin.This case of multiple nevoid hypertrichosis is reported with a review of previously reported cases.
Angiosarcoma Which Developed on the Abdominal Wall: Report of a Case
Authors: Funaki Mikio , Koike Shun'ichi , Dekio Satoshi , Jidoi Joji , Ohno Hiroyuki 
Published: April 2015

AbstractWe report a 68‐year‐old Japanese woman with angiosarcoma (AS) on the abdominal wall. To the best of our knowledge, she is the third such patient reported from Japan.
Acanthosis Nigricans Associated with Hepatolenticular Degeneration
Authors: Thaipisuttikul Yupin 
Published: April 2015

AbstractAcanthosis nigricans and hepatolenticular degeneration (Wilson's disease) developed simultaneously in a 16‐year‐old boy. The diagnosis of Wilson's disease was based on the clinical presentation, including Kayser‐Fleischer ring, hypoceruloplasminemia, hypocupremia, and hypercupriuria. His skin lesions were characterized by thick, dark brown, verrucous plaques on the dorsa of both feet, the neck, axillae, and groin. The histological findings were compatible with acanthosis nigricans. Six months after treatment with D‐penicillamine, two grams per day, his skin lesions and neurological symptoms were much improved and no complications were observed.
Pincer Nails and Alopecia as Markers of Gastrointestinal Malignancy
Authors: Jemec Gregor B.E. , Thomsen Kristian 
Published: April 2015

AbstractNail abnormalities may be markers of non‐dermatologic disease. We present a case in which pronounced pincer nails and universal alopecia developed in association with a metastasising adenocarcinoma of the sigmoid colon. It is suggested that this association represents a new ectodermal paraneoplastic syndrome.
Disseminated Superficial Porokeratosis in a Patient with Chronic Liver Disease
Authors: Park Byung Soon , Moon Sang Eun , Kim Jeong Aee 
Published: April 2015

AbstractA 55‐year‐old male suffering from liver cirrhosis presented with diffuse annular hyper‐keratotic papules of abrupt onset on the trunk and extremities. Histopathologic examination revealed cornoid lamella and eosinophilic spongiosis. He did not receive any medications other than cephalosporin for spontaneous bacterial peritonitis. A review of the literature revealed that three cases developed porokeratosis when their liver function declined and that, in one case, the porokeratosis disappeared spontaneously with liver transplantation. Although the precise mechanism is unclear, there is evidence demonstrating immunoincompetence in cirrhosis. Even though we did not perform immunologic studies or exclude the possibility of drug‐induced porokeratosis in our case, it is conceivable that porokeratosis can be triggered by immunosuppression due to liver cirrhosis per se.
Scaling Lichenoid Eruptions and Sjögren‐like Syndrome: Manifestations of Nonfatal Postoperative Transfusion‐Associated Graft‐versus‐Host Disease?
Authors: Tanei Ryoji , Yamamoto Tatsuo , Yokono Hideki , Motoori Tadashi 
Published: April 2015

AbstractWe report a case of an 81‐year‐old woman in whom lichenoid eruptions and Sjögren‐like sicca syndrome developed 45 days after cholecystectomy. During surgery, one unit (130 ml) of unirradiated packed red blood cells from a male donor was transfused. The lichenoid eruptions cleared up with exfoliation; however, sicca symptoms remained during the follow‐up period of four years. Histological examinations of both skin and lip biopsy specimens were in agreement with those of graft‐versus‐host disease (GVHD). A Y‐chromosomal body was identified in the lymphocytes in the skin lesion by staining with quinacrine dihydrochloride and in the lip lesion by a method with in situ hybridization. The findings suggest that this case demonstrated the manifestations of non‐fatal transfusion‐associated GVHD.
Inflammatory Nodules of the Lower Legs: A Clinical and Histological Analysis of 134 Cases in Korea
Authors: Cho Kwang Hyun , Kim Young Gull , Yang Seong Gyu , Lee Dong Youn , Chung Jin Ho 
Published: April 2015

AbstractWe analysed 134 Korean cases with inflammatory nodules of the lower legs on the basis of clinicopathological findings, responsiveness to various therapeutic agents, and clinical course. There were 53 cases of erythema induratum (EI), 18 of erythema nodosum (EN), 40 of EN‐like lesions of Behçet's disease, 15 of other entities, including superficial migratory thrombophlebitis, cutaneous periarteritis nodosa, sarcoidosis, malignant lymphoma, Churg‐Strauss syndrome, and parasitosis, and eight unclassified cases. The unclassified group was composed of a spectrum of diseases with clinicopathologic features ranging between those typical of EN and EI. The present study revealed that the profiles of diseases featuring inflammatory nodules of the lower legs in Korea differed from those found in other areas. These geographic and demographic differences should be kept in mind when managing a patient with inflammatory nodules of the lower legs.
A Case of Triple Extramammary Paget's Disease
Authors: Koseki Shin , Mitsuhashi Yoshihiko , Yoshikawa Kenichi , Kondo Shigeo 
Published: April 2015

AbstractWe report a 74‐year‐old Japanese man with triple extramammary Paget's disease; the genital and both of the axillar regions were simultaneously involved. Literature review revealed that 27 cases of triple extramammary Paget's disease have been reported in Japan, but there are no reports of triple extramammary Paget's disease from countries other than Japan, although 2 cases of double extramammary Paget's disease are reported. In all 28 cases, including our case, the genital lesion preceded the axillary lesions. All cases except one were male and only the exceptional female case was reported to have an the invasive tumor in the dermis. We speculate that extramammary Paget's disease may appear multi‐centrically.
A Case of Eccrine Poroma with Multiple Transepidermal Elimination
Authors: Arai Kazumori , Fujita Hiroshi , Suzuki Makoto , Iwasaki Kayoko 
Published: April 2015

AbstractThe skin functions to eliminate foreign substances through the epidermis to the epidermal surface; this process is called transepidermal elimination (TEE). TEE has been observed in various skin tumors. We encountered a 64‐year‐old male patient with eccrine poroma with marked TEE. A dark brown nodular papule appeared on the anterior aspect of his right leg about 20 years ago and gradually expanded. Histopathologically, cell nests of poroma were extruded to the epidermal surface at several sites. No erosion was noted, and mild to moderate inflammatory cell infiltration was observed in the upper layer of the dermis.According to Mehregan's classification, the TEE phenomenon observed in our case may correspond to types 2 and 3.
Microscopically Controlled Surgical Excision Combined with Ultrapulse CO2 Vaporization in the Management of a Patient with the Nevoid Basal Cell Carcinoma Syndrome
Authors: Krunic Aleksandar L. , Viehman Greg E. , Madani Shabnam , Clark Robert E. 
Published: April 2015

AbstractNevoid basal cell carcinoma syndrome is an autosomal dominant condition characterized by multiple basal cell carcinomas, skeletal abnormalities and sometimes mental retardation. The large number of tumors, which are often disfiguring, presents extreme difficulties in the treatment of these patients. Microscopically controlled excision, compared to other modalities (radiation therapy, photodynamic therapy, intralesional interferon alpha‐2b) offers the highest cure rate. However, because of the large size and involvement of wide areas of the skin, this approach is sometimes impractical. The ultrapulse CO2 laser with high energy and short pulses achieves char‐free ablation of the tumors, bloodless surgical field, minimal nonspecific thermal damage, rapid healing and diminished postoperative pain. Also, a number of lesions can be removed in a single session.We present a 48‐year‐old man with a 6.5 × 4.5 cm large basal cell carcinoma involving the anterior abdomen and navel area. The central thick portion of the tumor was resected by microscopically controlled excision with 3 stages, and wide thinner peripheral crescentic plaque vaporized with ultrapulse CO2 laser. The laser settings were 300 mJ energy/pulse and 100 W average power, which corresponds to the fluence of 7.5 J/cm2. Computerized pattern generator (ultrascan handpiece) was adjusted to patterns of 3 (circle) and 1 (square) with sizes varying from 5 to 7, and density of 9 (60% overlapping). The tumor was vaporized with 6 passes, all the way to deep reticular dermis. A fifteen month‐follow up disclosed no recurrent disease. Subsequent biopsies revealed only a scar with postinflammatory hyperpigmentation.Our experience indicates that combined treatment with microscopically controlled excision and ultrapulse CO2 laser ablation is a suitable modality for the large tumor plaques involving concave and convex areas of the skin respectively. Microscopically controlled excision of thicker, concave portions of basal cell carcinoma plaques, where CO2 laser surgery is less feasible, presents an effective addition that renders this combined modality a successful method for the treatment of nevoid basal cell carcinoma syndrome.
An Erythema Multiforme‐like Eruption Caused by Exposure to 1‐Chloromethylnaphthalene
Authors: Urano Shoko , Tokura Yoshiki 
Published: April 2015

AbstractA young male patient developed an erythema multiforme‐like eruption following an accidental exposure to 1‐chloromethylnaphthalene (1‐CMN). In addition to the skin lesion, he suffered from liver involvement and tear insufficiency. Positive results of a patch test with 1‐CMN and an in vitro lymphocyte transformation test suggested that direct exposure of the skin to chemical compounds was the probable cause of his symptoms.
Drug Eruption (Erythema Multiforme Type) Due to a Digestive Enzyme Drug
Authors: Miyoshi Hayao , Kanzaki Tamotsu 
Published: April 2015

AbstractAn 84‐year‐old Japanese male had pruritic indurated erythema on his upper limb and left lower abdomen, which had developed abruptly two months before visiting our hospital. Hematological examination showed eosinophilia, 550/mm3. Histopathological findings were suggestive of erythema multiforme in response to a drug. By means of patch tests and a p.o. challenge test, Aczym®, a digestive enzyme drug, was shown to be the cause of his condition. Further study revealed that the specific ingredients involved were pancreatin and Taka‐diastase. An eruption resulting from ingestion of a digestive enzyme drug has not previously been reported.
An Autopsy Case of Dermatomyositis with Rapidly Progressive Diffuse Alveolar Damage
Authors: Nobutoh Toshiko , Kohda Mamoru , Doi Yumiko , Ueki Hiroaki 
Published: April 2015

AbstractA 47‐year‐old woman visited a clinic with dyspnea which had continued for two months and was followed by general fatigue and fever. Antibiotics were not effective. Edematous erythema occurred on her face, elbows, knees and feet, and she entered our hospital. A skin biopsy revealed interface dermatitis with severe edema and mucinosis in dermis. Diffuse bilateral infiltration was observed in the chest X‐ray, and laboratory findings showed increased LDH, GPT, GOT and CPK. No antinuclear factor was detected. Her respiratory condition rapidly worsened, and she died eight days after hospitalization in spite of corticosteroid pulse therapy. The autopsy revealed that the main cause of death was diffuse alveolar damage (DAD).Interstitial pneumonia related to dermatomyositis is not histologically uniform; the response to the therapy depends on its histological type. The patients with dermatomyositis who have poor prognosis are clinically characterized by acute onset with general symptoms and less pronounced muscle weakness; they generally show DAD in their lungs. We need to establish a simple method for distinguishing histological types of interstitial pneumonia and adequate therapy for each one.
Disseminated and Recurrent Infundibular Folliculitis (D.R.I.F.): Report of a Case Successfully Treated with Isotretinoin
Authors: Aroni Kiriaki , Aivaliotis Markos , Davaris Panagiotis 
Published: April 2015

AbstractDisseminated and recurrent infundibular folliculitis, henceforth referred to as D.R.I.F., is a very rare, puritic, follicular, benign disease of unknown etiology seen mostly in black males. It is often self‐limited and usually unresponsive to local or systemic treatment. However, vitamin A, either alone or combined with vitamin E, is occasionally effective. We report a case of a patient with D.R.I.F. treated successfully with isotretinoin.
Is the Heredity of Reticulate Acro Pigmentation of Kitamura always Autosomal Dominant?
Authors: Singal Archana , Bhattacharya Sambit Nath , Baruah Manik Chand , Indrayan Abhay , Singh Navjeevan 
Published: April 2015

AbstractReticulate acropigmentation of Kitamura (RAK) in three patients and their families is described. In one family, 2 women and 2 men were affected out of 9 individuals. In the other family, 6 women had lesions of reticulate acropigmentation out of total of 27 over three generations. In the third family, one man was affected. All of the cases had palmar pits; onset of lesions was after puberty in all the cases. The apparently different hereditary patterns in these three families are striking, and autosomal dominant inheritance appears unlikely in every case.
A Case of Subungual Osteochondroma
Authors: Kim Seok Woo , Moon Sang Eun , Kim Jeong Aee 
Published: April 2015

AbstractSubungual osteochondroma is a rare form of benign bone tumor characterized by distinctive histopathological and radiological findings. The major clinical manifestation is a firm mass with tenderness. It must be differentiated from other similar diseases such as subungual exostosis, glomus tumor, and enchondroma to determine the proper surgical procedure.A 13‐year‐old boy had a history of a growing tender mass on the right third toe which recurred after simple excision. He was treated by careful dissection and total excision under local anesthesia. Histologic findings included a trabecular bone formation covered with hyaline cartilage cap and were compatible with osteochondroma.
Effect of an Inhibitor of Glucosylceramide Synthesis on Cultured Human Keratinocytes
Authors: Takami Yoshihiro , Abe Akira , Matsuda Takayoshi , Shayman James A. , Radin Norman S. , Walter Robert J. 
Published: April 2015

AbstractGlucosylceramide (GlcCer) is a major glycosphingolipid component of epidermis, which is thought to be related to the barrier function of skin permeability. However, the role of glycosphingolipids in keratinocyte growth and differentiation has not been fully clarified. It has been reported that D‐threo‐1‐phenyl‐2‐decanoylamino‐3‐morpholino‐1‐propanol (PDMP), an inhibitor of GlcCer synthase (EC 2.4.1.80), depletes cells of glycosphingolipids. This inhibitor has been used as a tool for elucidating their functions. In the present study, the effect of PDMP on cultured normal human keratinocytes was investigated. The cells were treated with various concentrations of PDMP. Forty‐eight hours later cell growth, thymidine incorporation, and lipid content were studied. The cell growth and the incorporation of thymidine into cells were inhibited by PDMP in a dose dependent manner. The synthesis of GlcCer was strongly inhibited by PDMP treatment, whereas no significant changes in ceramide level were observed. We concluded that GlcCer in epidermis may play an important role in regulating epidermal growth and suggested that PDMP may be beneficial for treating proliferative skin disorders in the future.
The Expression of Endothelin‐1 and Its Binding Sites in Mouse Skin Increased after Ultraviolet B Irradiation or Local Injection of Tumor Necrosis Factor α
Authors: Ahn Gun Young , Butt Khalid Iqbal , Jindo Toshimasa , Yaguchi Hitoshi , Tsuboi Ryoji , Ogawa Hideoki 
Published: April 2015

AbstractEndothelin (ET)‐1 is a 21‐amino acid peptide which has vasoconstrictor and growth regulatory activity. Recently, cultured keratinocytes have been reported to express ET‐1 and its receptor when irradiated by ultraviolet (UV) B. In order to further understand the role of ET‐1 in vivo during UVB‐induced inflammation, we examined the localization, intensity and time course of the expression levels of ET‐1 and its binding sites in UVB‐exposed BALB/c mouse skin. Frozen and paraffin sections prepared from mouse skin 48 h after treatment with UVB irradiation (0.36 or 0.72 J/cm2) or after injection with tumor necrosis factor (TNF)‐α (1.0 μg) or interleukin (IL)‐1α (0.05 μg) were incubated with monoclonal anti‐ET‐1 IgG and then visualized by peroxidase staining. In normal skin, faint ET‐1 immunoreactivity was observed in the epidermis, pilosebaceous structures and blood vessels. Upon exposure to UVB irradiation or administration of TNF‐α injection or IL‐1α injection, such immunoreactivity was found to be significantly enhanced. Subsequently, the frozen sections were incubated with 125I ET‐1 for 30 min, and visualized by autoradiographic technique. In normal skin, ET‐1 weakly bound to the skin, while UVB irradiation and TNF‐α injection significantly enhanced ET‐1 binding in the epidermis, pilosebaceous structures and blood vessels. Time course experiments (1, 2, 4 and 7 days) indicated that ET‐1 immunoreactivity and ET‐1 binding peaked 1 or 2 days after UVB irradiation or TNF‐α injection. These results suggest that the up‐regulated expression of ET‐1 and its binding sites in the epidermis and pilosebaceous structures may act as an autocrine/paracrine factor during UVB‐induced inflammation.
Spongiotic Annular Erythema in SS‐A/SS‐B Antibody Negative Sjögren's Syndrome
Authors: Higuchi Tetsuya , Taniguchi Hiroko , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractWe reported four cases of Sjögren's syndrome (SjS) who manifested a new type of annular erythema that differs from the previously described annular erythema seen in anti‐SS‐A/SS‐B antibody positive SjS in both clinical and histological findings. Characteristic histological features are the presence of spongiotic changes around the acrosyringium and perivascular lymphocytic infiltration without liquefaction degeneration or epidermal change, suggesting lupus erythematosus. No complement or immunoglobulin depositions are demonstrated along the basement membrane zone or around blood vessels. Clinically, this type of erythema usually appears on the trunk or extremities with itchy sensations, especially in summer, which contrasts with the preferential occurrence of the previously reported SjS related annular erythema on the facial skin in winter. Immunologically, all four cases lacked anti‐SS‐A and anti‐SS‐B antibodies, but possessed positive anti‐microsome antibodies or thyroid tests. In three cases, metal allergy was demonstrated by patch test, which might suggest that the sweat duct is the primary target of excreted metals in this condition and that underlying SjS might play some role in the higher prevalence of metal allergy or in induction of sweat duct injury, similar to the interstitial nephritis which is now thought to be an exocrine manifestation of SjS.
The Effectiveness of Modified Ingram Therapy Compared with Severity of Psoriasis
Authors: Youn Jai Il , Kim Byoung Kook , Suh Dae Hun 
Published: April 2015

AbstractTo treat cases of psoriasis, various modifications of the original Ingram method were tested for increased effectiveness and minimized side reactions. Our modified method consists of 0.1–0.5% anthralin ointment application and selective UVB phototherapy with adjunctive warm water bath and the application of emollients. The object of this study was to evaluate the effectiveness and duration of remission in response to our modified Ingram method and compare the data with the severity of psoriasis.The clearing rate was higher and the failure rate was lower in the moderate group. The number of occasions on which therapy was used and the duration of this therapy were greater in the severe group, but there were no significant differences except for the number of occasions of therapy to the trunk. Fifty‐eight percent of the moderate group did not relapse in more than one year, but 63% of the severe group relapsed within six months.The results of this study showed that the modified Ingram regimen is an effective therapeutic modality in psoriasis, especially in the moderate group.