bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposomal irinotecan + 5-fluorouracil/leucovorin + oxaliplatin as a first line treatment for the management of metastatic pancreatic adenocarcinoma: A budget impact analysis from a U.S. payer perspective.
Authors: Kim George P. , Holland Theo , Patrick Caity , Lewis Megan , Cockrum Paul , Eddy Alexandra 
Published: July 2024

e16339 Background: Metastatic pancreatic ductal adenocarcinoma (mPDAC) stands as the predominant pancreatic cancer type, affecting approximately 60,000 individuals in the United States (US) annually and nearly 500,000 globally. The prognosis for mPDAC is poor, with fewer than 20% of diagnosed individuals surviving beyond one year, and just 2.9% surpassing five-years. A phase 3 trial, NAPOLI-3, demonstrated statistically significant improved efficacy outcomes for NALIRIFOX compared with nab-paclitaxel + gemcitabine (Gem-Abraxane) as a first-line (1L) therapy for the treatment of mPDAC. NALIRIFOX showed an overall survival of 11.1 months compared with 9.2 months with Gem-Abraxane, and a significant improvement in progression free survival of 7.4 months compared with 5.6 months. In light of these efficacy outcomes, the objective of this analysis was to estimate the budget impact of adding NALIRIFOX for 1L treatment to a US health plan formulary over a one-year time horizon. Methods: The model estimated the difference in total costs and resource use between a current scenario without NALIRIFOX and a proposed scenario with NALIRIFOX. The eligible population was calculated using published prevalence and incidence data and applied to a hypothetical population plan of 1 million members (includes both commercial and Medicare insurance). NALIRIFOX was compared to the current standard of care (SoC) treatments with the highest market shares; FOLFIRINOX, Gem-Abraxane and Gemcitabine monotherapy, in the first year after marketing authorization. The following costs were included: acquisition, administration, resource monitoring utilization, adverse events (AE) and granulocyte-colony stimulating factor (G-CSF). Baseline characteristics, treatment duration and adverse events for NALIRIFOX and Gem-Abraxane were taken from NAPOLI-3 and published literature for other regimens. Results are presented in terms of the incremental budget impact (BI) and per member per month (PMPM) cost. One-way sensitivity analysis was performed. Results: For a plan of 1 million members, an estimated 132 individuals were eligible for 1L treatment for mPDAC. The PMPM budget impact was < $0.01. NALIRIFOX demonstrated notable cost savings, with reductions of 13.6%, 7.7%, and 1.1% observed in the G-CSF, AEs, and resource monitoring cost categories, respectively. Results were most sensitive to the treatment duration of NALIRIFOX. Conclusions: The model results indicate that the budget impact of NALIRIFOX may be minimal from a US health plan perspective. Given the poor prognosis of mPDAC, NALIRIFOX presents itself as an important new first line treatment option for people living with an aggressive and hard to treat cancer.
A phase I/II study to assess safety and preliminary evidence of a therapeutic effect of azeliragon combined with stereotactic radiation therapy in patients with brain metastases (ADORATION).
Authors: Kotecha Rupesh , Odia Yazmin , Chen Zhijian , Starosciak Amy K. , Rubens Muni , La Rosa Alonso , Herrera Susana , Ramirez Menendez Miguel A. , Pow-Sang Cristina I. , Ramos Suyen , Perez Jennifer , Ahluwalia Manmeet Singh , Mehta Minesh P. 
Published: July 2024

TPS2093 Background: The receptor for advanced glycation end-products (RAGE) is a multifunctional receptor which stimulates proliferation, invasion, resistance to chemotherapy and radiotherapy, and metastatic spread when activated. One of the RAGE ligands preferentially associated with brain metastasis, S100A9, has been recently identified as a specific mediator of radiotherapy resistance. RAGE also mediates neuroinflammatory pathways in the brain associated with peri-tumoral edema and cancer-related cognitive decline. Azeliragon is an oral small molecule agent that crosses the blood-brain barrier and inhibits RAGE interactions with its ligands, including S100A9. Consequently, the purpose of this study is to evaluate a new treatment paradigm with Azeliragon + stereotactic radiosurgery (SRS) for patients with brain metastasis to evaluate the safety and tolerability of the combined approach with the goal of minimizing the use of peri-procedural corticosteroids (loading dose [LD] and corticosteroid taper [CT]) as well was evaluating the potential radiosensitizing efficacy of this therapeutic combination. Methods: ADORATION is a single center, open-label, phase I/II cohort expansion trial to determine if azeliragon can be substituted for peri-procedural corticosteroids in patients undergoing SRS for brain metastasis. Eligible adults will have a confirmed cancer diagnosis in the last 5 years, a maximum tumor diameter of the largest brain metastasis ≤ 2 cm, and have discontinued corticosteroids at least 5 days prior to SRS. In phase I (n=up to 9), participants are enrolled into sequential cohorts, starting with azeliragon + SRS + LD. Depending on dose-limiting toxicities (DLTs) within 28 days of SRS, the next cohort will receive azeliragon + SRS alone or azeliragon + SRS + LD + CT. The phase II expansion cohort (n=up to 40 including the phase I cohort) will subsequently open with a primary endpoint of response rate. Azeliragon dosing includes a loading dose for 6 days followed by a continuous dose for at least 8 weeks, and SRS within 7 days of starting drug. Safety endpoints include number of DLTs and number of CNS treatment-related adverse events. Response endpoints include early brain metastasis response at 8 weeks, intracranial response at 6 and 12 months, and lesion specific local control. Neurocognitive batteries, symptom inventories, and quality-of-life questionnaires will also be administered. Three participants have been enrolled in the starting cohort and are pending DLT assessment. Clinical trial information: NCT05789589 .
Predation by the Pebas four-eyed opossums Philander pebas on the toad Rhinella margaritifera in the west Brazilian Amazon
Authors: Negreiros Almeida Marllus Rafael , Lima da Fonseca Wirven , Medeiros Borges Luiz Henrique , Bernarde Paulo Sérgio 
Published: July 2024

Las especies de Philander se encuentran en bosques tropicales y subtropicales. Algunas especies tienen una dieta compuesta por artrópodos, las especies dentro de este género se consideran depredadores oportunistas de vertebrados. La información sobre la historia natural, ecología y comportamiento de este género aún es escasa. Aquí presentamos el primer caso documentado de depredación de Rhinella margaritifera por parte de Philander pebas en el bosque de llanura aluvial amazónica. La observación documentada aquí, se realizó durante trabajos de campo en el Área de Relevante Interesse Ecológico Japiim-Pentecoste, en Cruzeiro do Sul, Acre, Brasil. Fotografiamos los registros utilizando una cámara con la ayuda de linternas. Encontramos 1 ejemplar de P. pebas moviéndose a través de lianas y hojas de palma. Observamos a la zarigüeya con una Rhinella margaritifera firmemente sostenido en su boca. El sapo estaba agarrado dorsalmente por la parte más ancha de su cabeza y ventralmente por parte de su cuello, abarcando las glándulas parotoides. Notamos que R. margaritifera en su boca estaba viva y mostraba un comportamiento defensivo conocido como "inflar el cuerpo". Sorprendentemente, la zarigüeya no mostró signos aparentes de efectos producidos por las toxinas mientras agarraba al sapo cerca de sus glándulas parotoides. Estos hallazgos desafían las suposiciones convencionales sobre los mecanismos de defensa del sapo contra los depredadores. Nuestro registro amplía la comprensión de las interacciones depredador-presa y destaca la importancia de realizar más investigaciones para desentrañar la dinámica de estas nuevas interacciones entre zarigüeyas y anfibios venenosos.
New records of jaguar (Panthera onca) in Península Papagayo, Guanacaste Conservation Area, Costa Rica
Authors: Araya-Gamboa Daniela , Pomareda-García Esther , Arroyo-Arce Stephanny , Espinoza-Muñoz Deiver , Araya-Jiménez Yosette , Thomson Ian , Chavez-Ramos Mónica , Salom-Pérez Roberto , Corrales-Gutiérrez Daniel , Fonseca Luis G. 
Published: July 2024

Aunque se sabe que los jaguares (Panthera onca) habitan en el Área de Conservación Guanacaste, Costa Rica, existen sectores dentro del área donde no se ha confirmado la presencia de la especie. Por lo tanto, en la presente nota documentamos los primeros registros de jaguar en Península Papagayo, Área de Conservación Guanacaste. Entre el periodo comprendido entre febrero y agosto de 2022 se emplearon métodos no invasivos, incluyendo cámaras trampa y extracción de ADN de muestras fecales, para determinar la presencia de la especie en el área de estudio. Después de 6,093 noches de muestreo, se identificaron 2 individuos adultos de jaguar (macho y hembra). Asimismo, de 30 muestras fecales colectadas, 4 fueron identificadas como heces de jaguar. Nuestros hallazgos constituyen la primera evidencia de la presencia del jaguar en Península Papagayo, y a nuestro conocer, constituyen los registros más al sur a lo largo de la costa Pacífica del Área de Conservación Guanacaste, Costa Rica.
Photographic grading to evaluate facial cleanliness and trachoma among children in Amhara region, Ethiopia
Authors: Caleon Ramoncito L. , Admassu Fisseha , Aragie Solomon , Hailu Dagnachew , Dagnew Adane , Zeru Taye , Wittberg Dionna M. , Thompson Isabel J. B. , Abdu Seid , Beyecha Social , Birhanu Tibebe , Getachew Habib , Getnet Banchalam , Kabtu Endale , Shibiru Meskerem , Tekew Solomon , Wondimteka Bilen , Lietman Thomas M. , Nash Scott D. , Freeman Matthew C. , Keenan Jeremy D. 
Published: July 2024

Background
Promotion of facial cleanliness is recommended for the elimination of blinding trachoma, largely because of observational studies that have found an association between various measures of facial uncleanliness and trachoma. However, when a field grader assesses both facial cleanliness and trachoma, associations may be biased. Assessment of photographs of the face and conjunctiva by masked graders may provide a less biased estimate of the relationship between facial cleanliness and trachoma.

Methods
Face photographs, conjunctival photographs, and conjunctival swabs were obtained on a random sample of 0–9-year-old children from each of 40 communities in Amhara region, Ethiopia. Face photographs were assessed for the presence of seven measures of an unclean face (i.e., wet nasal discharge, dry nasal discharge, wet ocular discharge, dry ocular discharge, food, dust/dirt, and flies) by three independent masked photo-graders. Conjunctival photographs were similarly graded in a masked fashion for signs of clinically active trachoma. Conjunctival swabs were processed for Chlamydia trachomatis DNA.

Results
Of 2073 children with complete data, 808 (39%) had evidence of clinically active trachoma, 150 (7%) had evidence of ocular chlamydia infection, and 2524 (91%) had at least one measure of an unclean face. Dry ocular discharge had the strongest association with clinically active trachoma (age- and sex-adjusted prevalence ratio [PR] 1.4, 95% CI 1.2–1.6) and ocular chlamydia infection (PR 1.9, 95%CI 1.3–2.9), although significant associations were observed between each of the measures of facial uncleanliness and trachoma.

Conclusions
Masked assessment of face and conjunctival photographs confirmed prior observational studies that have noted associations between various measures of facial uncleanliness and trachoma. The causal relationship between facial uncleanliness and trachoma is unclear since many features used to measure facial cleanliness (e.g., ocular discharge, nasal discharge, and flies) could be consequences of antecedent ocular chlamydia infection.

Trial registration
NCT02754583, clinicaltrials.gov.
Geospatial pattern of HIV seropositivity and its predictors among women in Ethiopia. A spatial and multiscale geographically weighted regression analysis
Authors: Kitaw Tegene Atamenta , Abate Biruk Beletew , Tilahun Befkad Derese , Haile Ribka Nigatu 
Published: July 2024

Background
Although promising efforts have been made so far, HIV remains a public health concern. Women in Ethiopia are disproportionately affected by HIV, accounting for a majority of new infections and AIDS-related deaths. However, the geospatial distribution of HIV among women in Ethiopia is not well understood, making it challenging to develop geographically targeted measures. Besides, to accelerate the pathway of decreasing HIV prevalence and plan geographically specific interventions, understanding the geospatial distribution of HIV seropositivity and its predictors among women plays a significant role.

Methods
A spatial and multiscale geographically weighted regression analysis was conducted using the 2016 EDHS dataset, comprising 14,778 weighted samples of women in the reproductive age group. The EDHS sample underwent two-stage stratification and selection. The data were extracted between October 18 and 30, 2023. Non-spatial analysis was carried out using STATA version 17. Additionally, ArcGIS Pro and Sat Scan version 9.6 were used to visually map HIV seropositivity. Global Moran’s I was computed to evaluate the distribution of HIV seropositivity. The Getis-Ord Gi* spatial statistic was utilized to identify significant spatial clusters of cold and hot spot areas. Geographically weighted regression analysis was subsequently performed to identify significant predictors of HIV seropositivity. Significance was established at a P-value <0.05 throughout all statistical analyses.

Results
HIV seropositivity among women in Ethiopia is distributed non-randomly (Global Moran’s I = 0.16, p-value <0.001 and Z-score = 7.12). Significant hotspot clustering of HIV seropositivity was found in the Addis Ababa, Harari, Dire Dawa, and Gambela region. Poor wealth index, being divorced and widowed, having more than one sexual partner, and early first sexual experience (<15 years) were found to be predictors of geographical variation of HIV seropositivity among women.

Conclusion
HIV seropositivity among women in Ethiopia varies geographically. Thus, deploying additional resources in high hotspot regions is recommended. Programs should focus on improving the economic empowerment of women to prevent the from engaging in risky sexual behaviors. Furthermore, comprehensive sex education programs in schools and community settings regarding the consequences of early first sexual debut might play a role in reducing HIV seropositivity among women in Ethiopia.
A realidade do mundo exterior em Ser e tempo à luz da crítica ao correlacionismo de Quentin Meillassoux
Authors: Fernandes Christiane Costa de Matos 
Published: July 2024

Resumo: Neste trabalho pretendo, em primeiro lugar, indicar o sentido geral da crítica ao correlacionismo de Meillassoux, isto é, a crítica à ideia dominante desde a filosofia transcendental de Kant, segundo a qual não temos acesso senão à correlação entre pensamento e ser. Em seguida, destacar a aporia indicada por essa crítica através do argumento da ancestralidade, e que expressa um limite da postura antirrealista própria à ideia correlacionista. Então, finalmente, analisar a primeira parte do §43 de Ser e tempo e discutir o alcance da aporia apresentada por Meillassoux em face da posição heideggeriana acerca da realidade do mundo exterior.
Palavras chave: Correlação; Realidade; Mundo
The reality of the exterior world in Being and time from Quentin Meillassoux's critique of correlationism
Abstract: In this paper I intend, firstly, to indicate the general meaning of Meillassoux's criticism of correlationism, i.e., the criticism of the dominant idea since Kant's transcendental philosophy, according to which we have access only to the correlation between thought and being. Next, I shall highlight the aporia indicated by this criticism through the argument of ancestry, which expresses a limit of the anti-realist stance associated with the correlationist idea. Then, finally, I analyze the first part of §43 of Being and time and discuss the scope of the aporia presented by Meillassoux in view of the Heideggerian position regarding the reality of the external world.
Keywords: Correlation; Reality; World
La realidad del mundo exterior en Ser y tiempo desde la crítica al correlacionismo de Quentin Meillassoux
Resumen: En este trabajo pretendo, en primer lugar, señalar el sentido de la crítica al correlacionismo de Meillassoux: la crítica a la idea dominante desde la filosofía trascendental de Kant, según la cual sólo se accede a la correlación entre pensamiento y ser. Luego, resaltar la aporía señalada por esta crítica, a través del argumento ancestral, que expresa un límite de la postura antirrealista propia de la idea correlacionista. Finalmente analizar la primera parte del §43 de Ser y tiempo y discutir el alcance de la aporía presentada por Meillassoux frente a la posición heideggeriana sobre la realidad del mundo externo.
Palabras clave: Correlación; Realidad; Mundo
Data de registro: 03/11/2022
Data de aceite: 23/08/2023
KEDIRI TOURISM DEVELOPMENT STRATEGY MANAGEMENT USING THE BLUE SEA STRATEGY APPROACH
Authors: Putro Dita Riyanto , Komari Ana , Indrasari Lolyka Dewi 
Published: July 2024

Competition in the tourism industry in Indonesia is currently very tight, with each region competing to highlight its uniqueness. With this very tight competition, Kediri Regency is trying to get out of the competition (red ocean) by creating innovations through the concept of the Blue Ocean Strategy. Blue Ocean Strategy is a term in the science of strategic management that refers to a strategy to create new markets that have not been filled with intense competition. Blue Ocean Strategy is a strategy to conquer competitors by offering innovative product features, which have so far escaped the attention of competitors. This study uses a qualitative methodology using the results of observations, interviews, and document reviews. While this type of research is categorized as descriptive research. This descriptive qualitative approach facilitates in-depth exploration of strategic management in tourism development using the Blue Ocean Strategy approach at the Kediri Regency Tourism and Culture Office. The results of the study show that tourism development with the Blue Ocean Strategy approach has not been implemented formally and officially, but the elements in the Blue Ocean Strategy approach have been adopted by the Tourism and Culture Office of the Kediri Regency in developing tourism using the value of innovation.
Fast and slow myofiber nuclei, satellite cells, and size distribution with lifelong endurance exercise in men and women
Authors: Montenegro Cristhian F. , Skiles Chad , Kuszmaul Dillon J. , Gouw Aaron , Minchev Kiril , Chambers Toby L. , Raue Ulrika , Trappe Todd A. , Trappe Scott 
Published: July 2024

AbstractWe previously observed lifelong endurance exercise (LLE) influenced quadriceps whole‐muscle and myofiber size in a fiber‐type and sex‐specific manner. The current follow‐up exploratory investigation examined myofiber size regulators and myofiber size distribution in vastus lateralis biopsies from these same LLE men (n = 21, 74 ± 1 years) and women (n = 7, 72 ± 2 years) as well as old, healthy nonexercisers (OH; men: n = 10, 75 ± 1 years; women: n = 10, 75 ± 1 years) and young exercisers (YE; men: n = 10, 25 ± 1 years; women: n = 10, 25 ± 1 years). LLE exercised ~5 days/week, ~7 h/week for the previous 52 ± 1 years. Slow (myosin heavy chain (MHC) I) and fast (MHC IIa) myofiber nuclei/fiber, myonuclear domain, satellite cells/fiber, and satellite cell density were not influenced (p > 0.05) by LLE in men and women. The aging groups had ~50%–60% higher proportion of large (>7000 μm2) and small (<3000 μm2) myofibers (OH; men: 44%, women: 48%, LLE; men: 42%, women: 42%, YE; men: 27%, women: 29%). LLE men had triple the proportion of large slow fibers (LLE: 21%, YE: 7%, OH: 7%), while LLE women had more small slow fibers (LLE: 15%, YE: 8%, OH: 9%). LLE reduced by ~50% the proportion of small fast (MHC II containing) fibers in the aging men (OH: 14%, LLE: 7%) and women (OH: 35%, LLE: 18%). These data, coupled with previous findings, suggest that myonuclei and satellite cell content are uninfluenced by lifelong endurance exercise in men ~60–90 years, and this now also extends to septuagenarian lifelong endurance exercise women. Additionally, lifelong endurance exercise appears to influence the relative abundance of small and large myofibers (fast and slow) differently between men and women.
On the overlapping discourse functions of Spanish ‘cómo que’ and French ‘comment ça’ interrogatives
Authors: Fliessbach Jan , Brunetti Lisa , Yoo Hiyon 
Published: July 2024

Abstract
We present evidence for an overlap in the discourse functions of Spanish cómo que XP ‘how thatcomplementizer’ and French comment ça ∅/XP ‘how thatdemonstrative’ interrogatives. We argue for three shared discourse functions: clarification requests, mirative questions, and expressions of disagreement. We show that these functions are cued by an interplay of morpho-syntactic and contextual factors. At the morpho-syntactic level, whether grammatical person shifts (is indirectly cited) compared to the previous turn and whether additional linguistic material (the ‘remnant’) is present after ‘how that’ were found to be important predictors of discourse function. At the contextual level, whether and how the speaker continues her turn after the interrogative is our most significant predictor. We quantify the degree to which these and other cues allow for a prediction of the discourse functions and find that the resulting model predicts more clarification request uses and fewer mirative and disagreement uses than empirically attested. This indicates that some cues for these two readings are missing from our model. We propose that prosody might be one of them.
Cultivating critical language awareness: unraveling populism in Trump’s inaugural address
Authors: Zhu Junling 
Published: July 2024

Abstract
Recent literature has revealed the upsurge of populism in political and media discourses across the world. However, few studies have acknowledged the importance of cultivating critical language awareness among citizens in democracies. Drawing on Halliday’s Systemic Functional Linguistics and Fairclough’s Critical Discourse, this study critically analyzes Trump’s populist meaning-making choices in his inaugural address through both genre and register analysis to raise the urgency of cultivating citizens’ critical language awareness through language education. To better illustrate Trump’s genre moves and rhetorical strategies, this study sometimes analyzes Trump’s inaugural address in comparison with other presidents’ inaugural addresses. The findings indicate that Trump employs a combination of populist rhetorical style, which includes anti-establishment, anti-elitism rhetoric; collectivist rhetoric; pro-nationalist sentiments; and linguistic choices of simplicity and repetition to appeal to both supporters and opponents in an attempt to build solidarity. The implications of this study center on raising educators’ and social scientists’ awareness of the urgency to cultivate critical language awareness among citizens through language education. Equipped with critical language awareness, citizens can understand how politicians use linguistic resources to engage, persuade, and manipulate their audiences to achieve their political goals, and thereby can make informed choices about political leaders in the future.