bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Successful Strategy for Increasing the Influenza Vaccination Rate of Healthcare Workers without a Mandatory Policy Outside of the United States: A Multifaceted Intervention in a Japanese Tertiary Care Center
Authors: Honda Hitoshi , Sato Yumiko , Yamazaki Akinori , Padival Simi , Kumagai Akira , Babcock Hilary 
Published: September 2013

Objective.Although mandatory vaccination programs have been effective in improving the vaccination rate among healthcare workers, implementing this type of program can be challenging because of varied reasons for vaccine refusal. The purpose of our study is to measure improvement in the influenza vaccination rate from a multifaceted intervention at a Japanese tertiary care center where implementing a mandatory vaccination program is difficult.Design.Before-and-after trial.Participants and Setting.Healthcare workers at a 550-bed, tertiary care, academic medical center in Sapporo, Japan.Interventions.We performed a multifaceted intervention including (1) use of a declination form, (2) free vaccination, (3) hospital-wide announcements during the vaccination period, (4) prospective audit and real-time telephone interview for healthcare workers who did not receive the vaccine, (5) medical interview with the hospital executive for noncompliant (no vaccine, no declination form) healthcare workers during the vaccination period, and (6) mandatory submission of a vaccination document if vaccinated outside of the study institution.Results.With the new multifaceted intervention, the vaccination rate in the 2012-2013 season increased substantially, up to 97%. This rate is similar to that reported in studies with a mandatory vaccination program. Improved vaccination acceptance, particularly among physicians, likely contributed to the overall increase in the vaccination rate reported in the study.Conclusions.Implementation of comprehensive strategies with strong leadership can lead to substantial improvements in vaccine uptake among healthcare workers even without a mandatory vaccination policy. The concept is especially important for institutions where implementing mandatory vaccination programs is challenging.
Is the Shale Energy Boom a Bust for Nearby Residents? Evidence from Housing Values in Pennsylvania
Authors: Gopalakrishnan Sathya , Klaiber H. Allen 
Published: September 2013

AbstractProfitable extraction of previously inaccessible shale energy reserves has led to the rapid expansion of shale exploration across the United States. We present one of the first empirical studies to measure the impact of early shale exploration on surrounding homeowners using data from Washington County, Pennsylvania, from 2008 to mid 2010. We find that property values are negatively impacted by shale gas exploration activity, but this impact depends on the proximity and intensity of shale activity and is largely transitory. The negative effects are larger for households located close to major highways and sourced with private well water.
Assessing the validity and reproducibility of genome-scale predictions
Authors: Sugden Lauren A. , Tackett Michael R. , Savva Yiannis A. , Thompson William A. , Lawrence Charles E. 
Published: September 2013

AbstractMotivation: Validation and reproducibility of results is a central and pressing issue in genomics. Several recent embarrassing incidents involving the irreproducibility of high-profile studies have illustrated the importance of this issue and the need for rigorous methods for the assessment of reproducibility.Results: Here, we describe an existing statistical model that is very well suited to this problem. We explain its utility for assessing the reproducibility of validation experiments, and apply it to a genome-scale study of adenosine deaminase acting on RNA (ADAR)-mediated RNA editing in Drosophila. We also introduce a statistical method for planning validation experiments that will obtain the tightest reproducibility confidence limits, which, for a fixed total number of experiments, returns the optimal number of replicates for the study.Availability: Downloadable software and a web service for both the analysis of data from a reproducibility study and for the optimal design of these studies is provided at http://ccmbweb.ccv.brown.edu/reproducibility.htmlContact: Charles_Lawrence@Brown.eduSupplementary information: Supplementary data are available at Bioinformatics online.
CLIPS-4D: a classifier that distinguishes structurally and functionally important residue-positions based on sequence and 3D data
Authors: Janda Jan-Oliver , Meier Andreas , Merkl Rainer 
Published: September 2013

Abstract
Motivation: The precise identification of functionally and structurally important residues of a protein is still an open problem, and state-of-the-art classifiers predict only one or at most two different categories.
Result: We have implemented the classifier CLIPS-4D, which predicts in a mutually exclusively manner a role in catalysis, ligand-binding or protein stability for each residue-position of a protein. Each prediction is assigned a P-value, which enables the statistical assessment and the selection of predictions with similar quality. CLIPS-4D requires as input a multiple sequence alignment and a 3D structure of one protein in PDB format. A comparison with existing methods confirmed state-of-the-art prediction quality, even though CLIPS-4D classifies more specifically than other methods. CLIPS-4D was implemented as a multiclass support vector machine, which exploits seven sequence-based and two structure-based features, each of which was shown to contribute to classification quality. The classification of ligand-binding sites profited most from the 3D features, which were the assessment of the solvent accessible surface area and the identification of surface pockets. In contrast, five additionally tested 3D features did not increase the classification performance achieved with evolutionary signals deduced from the multiple sequence alignment.
Availability: CLIPS-4D is available as a web-service at http://www-bioinf.uni-regensburg.de.
Contact: rainer.merkl@ur.de
Supplementary information: Supplementary data are available at Bioinformatics online.
Assessing gene-level translational control from ribosome profiling
Authors: Olshen Adam B. , Hsieh Andrew C. , Stumpf Craig R. , Olshen Richard A. , Ruggero Davide , Taylor Barry S. 
Published: September 2013

Abstract
Motivation: The translational landscape of diverse cellular systems remains largely uncharacterized. A detailed understanding of the control of gene expression at the level of messenger RNA translation is vital to elucidating a systems-level view of complex molecular programs in the cell. Establishing the degree to which such post-transcriptional regulation can mediate specific phenotypes is similarly critical to elucidating the molecular pathogenesis of diseases such as cancer. Recently, methods for massively parallel sequencing of ribosome-bound fragments of messenger RNA have begun to uncover genome-wide translational control at codon resolution. Despite its promise for deeply characterizing mammalian proteomes, few analytical methods exist for the comprehensive analysis of this paired RNA and ribosome data.
Results: We describe the Babel framework, an analytical methodology for assessing the significance of changes in translational regulation within cells and between conditions. This approach facilitates the analysis of translation genome-wide while allowing statistically principled gene-level inference. Babel is based on an errors-in-variables regression model that uses the negative binomial distribution and draws inference using a parametric bootstrap approach. We demonstrate the operating characteristics of Babel on simulated data and use its gene-level inference to extend prior analyses significantly, discovering new translationally regulated modules under mammalian target of rapamycin (mTOR) pathway signaling control.
Availability: The Babel framework is freely available as source code at http://taylorlab.ucsf.edu/software_data.html.
Contact: barry.taylor@ucsf.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Intrathecal Substance P-Saporin in the Dog
Authors: Wiese Ashley J. , Rathbun Michael , Butt Mark T. , Malkmus Shelle A. , Richter Philip J. , Osborn Kent G. , Xu Qinghao , Veesart Samantha L. , Steinauer Joanne J. , Higgins Denise , Lappi Douglas A. , Russell Brian , Yaksh Tony L. 
Published: September 2013

Abstract

Background:
Neurokinin-1 receptors (NK1-rs) located on superficial dorsal horn neurons are essential for integration of nociceptive input. Intrathecal injection of substance P-saporin (SP-SAP) leads to local loss of spinal NK1-r (+) neurons suggesting its potential as a therapeutic agent for chronic pain. The authors determined, in a canine model, effects of lumbar intrathecal SP-SAP.

Methods:
Distribution of SP-SAP and Saporin was determined in plasma, lumbar cerebrospinal fluid, and tissue. Safety of intrathecal SP-SAP was determined in four groups (six dogs each) administered 0 (0.9% saline), 1.5, 15, or 150 µg SP-SAP through lumbar intrathecal catheters. Behavioral, physiologic, and biochemical variables were assessed. Spinal tissues were collected at 7 and approximately 90 days, or earlier if significant morbidity developed, and analyzed for NK1-r (+) neuron loss and histopathology.

Results:
SP-SAP and Saporin were detectable in lumbar cerebrospinal fluid for up to 4 and 24 h, respectively. Animals receiving intrathecal saline, 1.5, or 15 µg of SP-SAP showed no persistent neurologic deficits. Three animals receiving 150 µg of SP-SAP developed pelvic limb paraparesis and were euthanized prematurely. Immunohistochemistry and in situ hybridization cell counts confirmed a significant reduction in NK1-r (+) in superficial dorsal horn neurons from lumbar spinal cord after intrathecal administration of 15 and 150 µg of SP-SAP. A significant loss of NK1-r neurons in the lumbar ventral horn occurred only with 150-µg SP-SAP.

Conclusion:
Intrathecal 15-µg SP-SAP reduced dorsal, but not ventral, NK1-r (+) neurons at the spinal level of delivery with minimal side effects, whereas 150-µg SP-SAP resulted in motor neuron toxicity.
Is Folic Acid Supplementation Really Necessary in Preterm Infants ≤32 Weeks of Gestation?
Authors: Oncel Mehmet Yekta , Calisici Erhan , Ozdemir Ramazan , Yurttutan Sadik , Erdeve Omer , Karahan Sevilay , Dilmen Ugur 
Published: September 2013

ABSTRACTObjectives:The aim of this study was to define whether there was folate deficiency in hospitalized preterm infants, and, second, to define the effect of feeding modalities on serum folate levels.Methods:Infants born ≤32 weeks of gestation were included in the study. Blood samples for the determination of serum folate levels were obtained on days 14 and 28 postnatally, as well as 36 weeks postconceptionally (or just before discharge if patients are discharged <36 weeks)—samples A, B, and C, respectively. Infants were divided into 3 groups based on mode of feeding; human breast milk (HBM), fortified HBM (fHBM), or preterm formula (PF).Results:A total of 162 preterm infants were enrolled: 17 (10.5%) of whom received HBM alone, 94 (58%) received fHBM, and 51 (31.5%) were fed with PF. None of the preterm infants developed folate deficiency during the study period. Preterm infants in the fHBM and PF groups had significant higher serum folate levels in samples C when compared with those receiving HBM alone (P < 0.001 for both). Multivariate analysis to evaluate the effects of maternal supplementation, smoking habit, gestational age, birth weight, and cumulative folic acid intake in samples A, B, and C suggested that maternal smoking and maternal folic acid supplementation had significant effects on serum folate levels in sample A and B.Conclusions:Preterm infants receiving parenteral nutrition with high folic acid content have no risk of folate deficiency during the 2 months of age; however, preterm infants fed orally from birth with HBM or PF with a low folic acid content could be at risk for folate deficiency, especially when mothers are smokers and/or do not receive folic acid supplementation during pregnancy.
Pipeline Embolization Device
Authors: Sise Adam B. , Osher James M. , Kolsky Martin P. , Stemer Andrew , Bank William O. , Garfinkel Richard A. 
Published: September 2013

Abstract:
A 57-year-old woman underwent treatment of a left internal carotid artery aneurysm with a Pipeline embolization device. She subsequently experienced multiple branch retinal artery occlusions in her left eye. Although rare, ophthalmic complications may follow this new technique in the treatment of intracranial aneurysms.
Sustainability reports as simulacra? A counter-account of A and A+ GRI reports
Authors: Boiral Olivier 
Published: September 2013

Purpose
– The purpose of this paper is to examine the extent to which sustainability reporting can be viewed as a simulacrum used to camouflage real sustainable-development problems and project an idealized view of the firms' situations.

Design/methodology/approach
– The method was based on the content analysis and counter accounting of 23 sustainability reports from firms in the energy and mining sectors which had received application levels of A or A+ from the Global Reporting Initiative (GRI). The information disclosed in some 2,700 pages of reports was structured around 92 GRI indicators and compared with 116 significant news events that clearly addressed the responsibility of these firms in sustainable development problems. Moreover, the 1,258 pictures included in sustainability reports were categorized into recurring themes from an inductive perspective.

Findings
– A total of 90 per cent of the significant negative events were not reported, contrary to the principles of balance, completeness and transparency of GRI reports. Moreover, the pictures included in these reports showcase various simulacra clearly disconnected with the impact of business activities.

Originality/value
– The paper shows the relevance of the counter accounting approach in assessing the quality of sustainability reports and question the reliability of the GRI's A or A+ application levels. It contributes to debates concerning the transparency of sustainability reports in light of Debord's and Baudrillard's critical perspective. The paper reveals the underexplored role of images in the emergence of several types of simulacra.
Just a passing fad?
Authors: Vinnari Eija , Laine Matias 
Published: September 2013

Purpose
– The study seeks to add to the understanding of the diffusion and decline of environmental reporting practices.

Design/methodology/approach
– Semi-structured interviews and municipal water utility publications are analysed to identify factors which have influenced the diffusion and subsequent decline of environmental reporting practices within the Finnish water sector.

Findings
– The findings suggest a dynamic view of the diffusion and decline of environmental reporting, showing that a variety of forces operated jointly over time. The initial swift diffusion may be mostly explained from the perspectives of fad and fashion, whereas the subsequent gradual decline of such reporting appears to have been driven mainly by internal organizational factors and a lack of outside pressure.

Research limitations/implications
– The paper relies on a qualitative dataset, implying that extensive care is needed when seeking to generalise or apply the findings to different contexts or organizational fields.

Practical implications
– The findings presented here should prove interesting for public sector managers, who are considering how, if at all, their organization should engage in social and environmental reporting.

Originality/value
– The paper provides new insights into public sector sustainability reporting and presents reasons for its decline. In addition, the analysis illustrates the applicability of Abrahamson's typology of innovation diffusion to the study of social and environmental reporting practices.
Effectiveness of brief training in cognitive-behaviour therapy techniques for staff working with people with intellectual disabilities
Authors: Dodd Karen , Austin Katie , Baxter Laura , Jennison Jo , Kenny Mark , Lippold Tessa , Livesey Alexandra , Lloyd Julie , Anne Nixon Julie , Webb Zillah , Wilcox Esther 
Published: September 2013

Purpose
– There is little research addressing the delivery of training for health professionals who are interested in using cognitive-behaviour therapy (CBT) techniques as an adjunct to their current role. This paper describes the establishment and evaluation of a CBT training course to develop CBT skills in staff working with people with intellectual disabilities in Trust healthcare settings. The course would enable staff to learn how they could incorporate these skills into their daily practice to help them understand and work more effectively with people with intellectual disabilities.

Design/methodology/approach
– A CBT training course was designed to teach staff the use of a number of basic and specific CBT techniques and principles that staff could use within their current roles. Specific issues in relation to people with intellectual disabilities were included, e.g. understanding cognitive deficits as well as cognitive distortions. The course ran for six sessions on a fortnightly basis, followed by a two-month follow-up session. Participants completed a pre- and post-assessment questionnaire and kept a reflective diary.

Findings
– The training clearly focused on teaching skills that were feasible for staff to use in their own work settings. The evaluations, especially from the reflective diaries and the post-course questionnaires clearly demonstrated that this aim was achieved.

Originality/value
– This was a pilot study as there has been no previously published evidence of using this approach within intellectual disabilities services. A further training course has been planned to continue evaluating the effectiveness of this approach.
The use of mechanical restraint with people who engage in severe self-injurious behaviour: impact on support staff
Authors: Bethel Nicola , Beail Nigel 
Published: September 2013

Purpose
– There continues to be a small group of people who have intellectual disabilities who need some form of restraint in their support plan due to their self-injurious behaviour. The mechanical restraint restricts their freedom of movement to help prevent injury. Despite the growing literature on the use of such devices, there is very limited literature looking at the impact the use of mechanical restraints has upon service users and support staff using them. The aim of this study was to ascertain the experiences of support staff who apply the restraints to the people they support.

Design/methodology/approach
– Qualitative methodology was utilised. A semi-structured interview was conducted with nine support workers who: directly worked with a client with intellectual disabilities who engage in self-injurious behaviours; followed positive behavioural support plans developed with a multi-disciplinary team; applied restraints as a response to severe self-injurious behaviours to prevent harm; and they had to have been directly involved in the application and removal of the mechanical restraints in the last week. Content analysis utilising emergent coding was used to analyse the data.

Findings
– All participants described using mechanical restraints as having a negative impact upon them. Participants said they manage the negative impact by reframing, inhibiting their emotions, following support plans closely and gaining support from other staff. Participants described concerns and unmet needs regarding whether they were applying the restraints correctly, the responsibility of teaching others to use restraints, not feeling prepared on starting their current job and that the impact/concerns of using restraints is not talked about. Recommendations for practice are made.

Originality/value
– This is the first study to explore the views of care staff who are required to use mechanical restraint. It provides insight on the impact of this on them.
Neural-FEM approach for the analysis of hysteretic materials in unbounded domain
Authors: Coco Salvatore , Laudani Antonino , Riganti Fulginei Francesco , Salvini Alessandro 
Published: September 2013

Purpose
– This paper aims the application of a novel synergy between a neural network (NN) and the finite element method (FEM) in the solution of electromagnetic problem involving hysteretic material in unbounded domain.

Design/methodology/approach
– The hysteretic nature of the material is taken into account by an original NN able to perform the modelling of any kind of quasi-static loop (saturated and non-saturated, symmetric or asymmetric). An appositely developed iterative FEM procedure is presented for the solution of this kind of problems in unbounded domains.

Findings
– By starting from a small set of measured loops, the NN manages the values of the magnetic field, H, and the flux density, B, as inputs while the differential permeability is the output. In particular, the proposed NN is capable to perform the modelling of saturated and non-saturated, symmetric or asymmetric hysteresis loops.

Practical implications
– The development of an efficient method for the solution of a complicated electromagnetic problem in unbounded domain by using an iterative approach and NNs, which can be implemented also in existing FEM code.

Originality/value
– The paper shows that the combination of FEM, iterative procedure and NNs allows us to produce effective solutions of electromagnetic problems in unbounded domains involving also nonlinear hysteretic magnetic materials with an acceptable computational cost.
Review of parallel and distributed architectures for micromagnetic codes
Authors: Khan Omar , Khan Fiaz , Ragusa Carlo , Montrucchio Bartolomeo 
Published: September 2013

Purpose
– Rapid advancements in computer technologies over the past decade have recorded significant growth in the area of computational micromagnetics. As a result, current micromagnetic codes exploit the scalability offered by parallel and distributed computer architectures to deliver maximum performance. The purpose of this paper is to present a review, which explores various aspects of this relationship.

Design/methodology/approach
– The authors arrange the theme for this paper around the micromagnetic code development process. The review involves a discussion of the micromagnetic model, some new parallel architectures, and computational aspects based on different numerical methods.

Findings
– As current micromagnetic code is not readily portable to different architectures, most of the development effort goes towards this area, with a focus on writing/rewriting code for streaming hardware (particularly graphic cards).

Originality/value
– The paper identifies key challenges and avenues for further research on computational aspects of micromagnetic modelling and suggests recommendations based on the review.