bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Simple and Sequential Strategy for the Introduction of Complexity and Hierarchy in Hydrogen‐Bonded Organic Framework (HOF) Crystals for Environmental Applications
Authors: Halliwell Christopher A. , Jolley Kenny , Yendall Keith , Elsegood Mark R. J. , Parkinson Gary N. , Fernandez Antonio 
Published: July 2024

AbstractHydrogen‐bonded organic frameworks (HOFs) are a new class of crystalline porous organic molecular materials (POMMs) with great potential for a diverse range of applications. HOFs face common challenges to POMMs, and in general to purely organic crystals, that is, the difficulty of integrating complexity in crystals. Herein, we propose a simple and sequential strategy for the formation of HOFs with hierarchical superstructures. The strategy is based on controlling the assembly conditions, avoiding the use of any surface functionalization or template, which allows to obtain hierarchical crystalline porous superstructures in an easy manner. As proof of concept, we obtained the first example of core–shell (HOF‐on‐HOF) crystals and HOFs with hierarchical superstructures having superhydrophobicity and trapping abilities for the capture of persistent water contaminants such as oils and microplastics. We expect that this strategy could serve as inspiration for the construction of more intricate multiscale structures that could greatly expand the library of HOF materials.
Electrochemical Skeletal Indole Editing via Nitrogen Atom Insertion by Sustainable Oxygen Reduction Reaction
Authors: Zhang Bo‐Sheng , Homölle Simon L. , Bauch Tristan , Oliveira João C. A. , Warratz Svenja , Yuan Binbin , Gou Xue‐Ya , Ackermann Lutz 
Published: July 2024

AbstractSkeletal molecular editing gained considerable recent momentum and emerged as a uniquely powerful tool for late‐stage diversifications. Thus far, superstoichiometric amounts of costly hypervalent iodine(III) reagents were largely required for skeletal indole editing. In contrast, we herein show that electricity enables sustainable nitrogen atom insertion reactions to give bio‐relevant quinazoline scaffolds without stoichiometric chemical redox‐waste product. The transition metal‐free electro‐editing was enabled by the oxygen reduction reaction (ORR) and proved robust on scale, while tolerating a variety of valuable functional groups.
Bimetallic magnetic nanoparticles dispersed in glycerol: An efficient hydrophilic catalyst for the reduction of 4‐nitrophenol
Authors: Mary Selvaraj Angel Anusuya , Stella Selvaraj 
Published: July 2024

A one‐pot, ecologically friendly method for the preparation of Fe/Ni, Fe/Co and Co/Ni bimetallic magnetic nanoparticles (MNPs) was reported, using glycerol as both a solvent and reducing agent. Six different bimetallic MNPs by varying the proportions of transition metals, namely, Fe, Co and Ni were synthesized by the chemical reduction method. The catalytic efficiency of the synthesized nanoparticles (NPs) was explored for the reduction of 4‐nitrophenol, and the reaction rate for different catalysts was systematically analysed. Especially, glycerol‐Fe/Co (1:3) bimetallic nanoparticles as a magnetically recoverable catalyst had higher catalytic activity than the other bimetallic nanoparticles for the reduction of 4‐nitrophenol to 4‐aminophenol in the presence of sodium borohydride. The reduction process was monitored by UV–visible spectroscopy, and the reaction was complete within 8 min. The kinetic study shows 99% conversion of 4‐nitrophenol to 4‐aminophenol, and the rate constant is 0.593 min−1. Furthermore, the glycerol‐Fe/Co (1:3) MNPs were retrieved from the reaction mixture and subsequently utilized in five consecutive cycles, demonstrating both the reusability and durability of the NPs as a catalyst. This research was remarkable for its fast reaction kinetics, simplified one‐pot conversion of 4‐nitrophenol to 4‐aminophenol without the need for mechanical or magnetic stirring and in‐depth study of six bimetallic MNPs' catalytic properties in nitro reduction. These findings explored the potential benefits of bimetallic magnetic NPs for the synthesis of 4‐aminophenol products.
Deep eutectic solvent engineered GO/ZrO2 nanofiller for mixed matrix membranes: An efficient hydrogen gas separation
Authors: Chavda Vishwajit , Patel Harsh D. , Patel A. K. , Hirpara Darshna , Acharya N. K. , Kumar Sanjeev 
Published: July 2024

AbstractThis study explores fabrication and characterization of mixed matrix membranes (MMMs) for gas separation, employing a cost‐effective solution casting method. Polycarbonate (PC) and polystyrene (PS) blends are combined with graphene oxide (GO) and zirconium dioxide (ZrO2) nanofillers, with and without a deep eutectic solvent (DES) obtained through hydrogen bond exchange. Various MMMs compositions (2–20 wt%) are systematically examined using diverse characterization techniques, including differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, porosity determination, and water contact angle analysis. The MMMs exhibit enhanced gas permeability and selectivity, surpassing conventional membrane materials. Notably, H2 gas permeability reaches outstanding levels, with the composition PC/PS‐DES‐GO/ZrO2 at 20 wt% (PBC20‐IV) demonstrating the highest value of 86.32 Barrer. This superior performance is attributed to the unique properties of ZrO2, increased sorption capacity of GO, and enhanced thermal stability due to DES. Permeability data for CO2, N2, O2, and CH4 also show significant values, aligning with the observed trends in H2 permeability. Robeson's plot for the H2/CO2 gas pair surpasses the 2008 upper bound, placing the MMMs in a novel category for gas separation membranes. The incorporation of DES‐modified nanofiller blend composites presents a promising strategy for the potential production of pure hydrogen.
Torrefied spent coffee grounds as biofillers for poly(butylene adipate‐co‐terephthalate) biocomposites
Authors: Kim Youngsan , Kwon Sangwoo , Park Su‐il 
Published: July 2024

AbstractIn this study, poly(butylene adipate‐co‐terephthalate) (PBAT) biocomposites were generated from spent coffee grounds (SCGs) or torrefied SCG (TSCGs) using a melt compounding process. TSCGs were obtained at torrefaction temperatures of 230, 245, 260, 275, or 290°C for a duration of 60 min. Torrefaction enhanced the hydrophobicity, grindability, and biomass stability of the resulting composites by eliminating hemicellulose. Various concentrations of SCGs (10 and 20 wt.%) and TSCGs (10, 20, and 30 wt.%) were compounded into PBAT. The thermal, mechanical, and degradation properties of PBAT biocomposites were investigated. As SCGs and TSCGs were introduced, the crystallization temperature drastically increased. Compared with PBAT biocomposites with SCGs, PBAT biocomposites with TSCGs exhibited higher thermal stability and hydrophobicity, and improved mechanical properties. Further, alkaline hydrolysis occurred at a faster rate for biocomposites with biofillers than for neat PBAT. Therefore, this study demonstrated the improved compatibility between SCGs and PBAT by torrefaction.
Improvement of polycaprolactone and polyethylene glycol flexible polymeric film enhances bone volume and interconnectivity in bone lesions through transport of mesenchymal stem cells differentiated to osteoblasts
Authors: Jayme Cristiano C. , Fernandes Daniela S. , Matsuo Flávia S. , de Paula Leonardo B. , Osako Mariana K. , Tedesco Antonio C. 
Published: July 2024

AbstractBone fractures are one of the most common types of human injury. This study aimed to create a synergistic action of polymeric films (PFs) based on polycaprolactone (PCL) and polyethylene glycol (PEG) (PCL‐PEG‐PFs) deposited by casting, combined with mesenchymal stem cells (MSCs) that differentiate into osteoblasts for bone regeneration. In vitro experiments indicated that the PCL‐PEG‐PFs (70:30) exhibited low cytotoxicity and enhanced cell adhesion capacity. In vivo studies were performed to evaluate the bone regeneration capacity of PFs with MSCs that adhered to and differentiated into osteoblasts. The cell differentiation process was carried out for 18 days in cell culture for subsequent implantation in the calvaria of male C57BL/6J mice, which remained in contact with the bone lesion for another 14 days. In vivo studies indicated that the application of PCL‐PEG‐PFs (70:30) increased the bone surface area to the total volume, with significant regeneration areas (levels greater than 25%) and interconnectivity compared to the control. In addition, the generated tissue presented cells with a morphology comparable to that of the peripheral tissue of the injured region, indicating a positive synergistic interaction between PCL‐PEG‐PFs (70:30) and MSCs differentiated into osteoblasts in contact with the bone lesion.
Flexible and recyclable thermally conductive phase change composites with shape stability
Authors: Xu Yaofei , Sun Junyan , Feng Yixin , Lin Bili , Luo Fubin 
Published: July 2024

AbstractForm‐stable and flexible highly thermally conductive phase change composites are crucial for thermal management. In this work, based on the associative exchangeable crosslinkers derived from the reaction of epoxidized soybean oil (ESO) and sebacic acid (SA), a kind of flexible and recyclable thermally conductive phase change composite with shape stability is prepared. The shape stabilization is achieved through the co‐cooperation of expanded graphite (EG) and the dynamic covalent crosslinking network. The thermal conductivity is enhanced by embedding with boron nitride (BN). When the mass fraction of BN is 25%, the thermal conductivity of the composite can reach 4.03 W/(m·K). The results indicate that the prepared PCMs composites have excellent flexibility and form stability, suggesting the potential application in the thermal management for electronic devices. The presence of dynamic exchangeable bonds makes the matrix degradable under mild conditions, enabling the recycling of valuable thermally conductive fillers, which proves to be highly sustainable. This work introduces a novel method for preparing flexible and recyclable thermally conductive phase change composites with shape stability vitrimer.
Electrospun chitosan/polymethyl methacrylate nanofiber membranes integrated with polyethyleneimine for enhanced removal of chromium(VI) ions
Authors: Yu Mengyun , Xu Weiwei , Sun Jianjun , Liu Zhiyong , Ding Guangjun , Gao Jiangang , Zhang Zongrui 
Published: July 2024

AbstractThis study demonstrates the preparation of a unique chitosan (CS)/polymethyl methacrylate (PMMA)/polyethyleneimine (PEI) nanofiber (NF) membrane using PMMA as the composite skeleton through an electrospinning method. The chemical and mechanical properties, chromium (Cr) adsorption capabilities, and mass transfer mechanisms of the NF membrane were thoroughly investigated. The findings indicate that the CS/PMMA/PEI NF membranes, with an average diameter of approximately 856.2 nm, exhibits favorable hydrophilicity, effective Cr(VI) adsorption (first adsorption capacity of 226.5 mg g−1), and robust mechanical properties (tensile strength of 1.58 ± 0.092 Mpa), which is superior to most reported adsorbents. Moreover, the composite NF membranes exhibit a second adsorption capacity of 194.4 mg g−1 and a tensile strength of 0.739 ± 0.072 Mpa after the second adsorption, indicating a remarkable level of reusability and cycle stability. Additionally, x‐ray photoelectron spectroscopy, and structural tests reveal the presence of abundant amino (NH2) and hydroxyl (OH) groups in the CS/PMMA/PEI NF membranes, suggesting potential sites for complexation reactions and the reductions of Cr(VI) ions, thereby facilitating effective adsorption and removal of heavy metals. This study introduces a novel and straightforward approach for synthesizing highly effective adsorbents, with have potential implications for the removal of heavy metal ions from wastewater.
Carbon dioxide‐based poly(hydroxyurethane‐urea) elastomers: Synthesis, microphase structure, and properties
Authors: Jiang Shan , Han Tianyi , Tian Tongshuai , Yang Chuanqing , Liu Li 
Published: July 2024

AbstractCompared with isocyanate‐based polyurethanes (PUs), poly(hydroxyurethane)s (PHUs) are more likely to form phase mixing structure, inducing poor elastic properties. To avoid this, stronger interaction between hard segments is required. Herein, carbon dioxide‐based poly(hydroxyurethane‐urea)s (PHUUs) with different hard segment contents were prepared through polyaddition reaction using 5‐membered dicyclic carbonate (BADC) as hard segment, poly(propylene glycol) bis(2‐aminopropyl ether) (D2000) as soft segment, and amino‐terminal polyurea oligomer (HMDA*) chain extender, and several PHUs were prepared by using hexamethylenediamine (HMDA) chain extender or without using chain extender as controls. The interaction between hard segments were strengthened with the introduce of chain extender. Compared with PHUs, PHUUs with HMDA* chain extender were more inclined to form significant microphase separation. For PHUUs, the hard segment Tg appeared at around 60°C when hard segment content reached 40 wt%, and the interdomain spacings were in the range of around 14–23 nm with 40–50 wt% hard segment content. In addition, PHUUs exhibited better solvents resistance and mechanical properties than PHUs with the same hard segment content. PHUUs with certain hard segment content showed good elastic recovery, with a residual strain less than 2% after 10 cycles, which comparable with conventional isocyanate‐based PUs.
Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses
Authors: Babapour Fatemeh , Faraji Rad Zahra , Ganji Fariba 
Published: July 2024

AbstractTransdermal drug delivery using dissolving microneedles (DMNs) is promising due to increased patient compliance and safety. This article presents a comprehensive simulation and experimental analysis of DMNs with varying tip and base diameters and polymers. The objective of the simulation study is to identify the optimal tip and base diameter of DMNs, as well as the most suitable polymer, for achieving maximum penetration depth. The simulation results showed that the compound consisting of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) in a ratio of 2:1, with a tip radius of 17.5 μm and a base radius of 150 μm, achieved the deepest penetration among the different types of polymers investigated (including PVA, hyaluronic acid (HA), and PVA/PVP in ratios of 1:1 and 1:2). In addition, mechanical and skin penetration experiments were performed on PVA/PVP 2:1 DMNs with varying concentrations of 4, 7, 10, and 15% w/w to determine the optimal polymer concentration. The results of this study indicated that the optimal composition, considering the viscosity of the polymer solution and the simplicity of filling the silicone negative molds, is a PVA/PVP 2:1 with a concentration of 7% w/w.
Robust stability and H∞$$ {H}_{\infty } $$ performance evaluation for time‐varying‐delayed uncertain linear systems based on variable‐augmented‐based free‐weighting matrices
Authors: Chen Dong‐Shuai , Shangguan Xing‐Chen , He Yong 
Published: July 2024

AbstractThe problem of the robust stability and
performance evaluation of time‐varying‐delayed uncertain linear systems (TVDULSs) is studied in this article. At first, to obtain a modified robust delay‐dependent condition of TVDULSs, a novel augmented Lyapunov‐Krasovskii functional (LKF) is established, and a variable‐augmented‐based free‐weighting matrices (VAFWMs) technique is tailored to evaluate the functional derivative. Compared with the existing robust stability methods, the constructed functional takes fully time delay information of the system into consideration and provides more delay‐cross terms, where the corresponding matrices are used to relax the constraints of linear matrix inequalities in the stability condition. Also, the VAFWMs method fully considers the linear relation of some delayed integral terms in the functional derivative, which avoids the usage of a quadratic order or higher order terms of the time delay. Then, an improved
performance analysis criterion of TVDULSs is obtained against the disturbance on the basis of the proposed robust stability condition. The admissible maximal delay upper bounds that the uncertain linear system can tolerate are provided by proposed criterion under a given
performance level. At last, two numerical examples are presented to verify the effectiveness and the superiority of the methods obtained.
RNA sequencing reveals the potential mechanism of exercise preconditioning for cerebral ischemia reperfusion injury in rats
Authors: Wu Yan , Yang Hui , Chen Feifeng , Li Baohua , Meng Xiangbo 
Published: July 2024

AbstractIntroductionCerebral ischemia reperfusion injury (CIRI) often leads to deleterious complications after stroke patients receive reperfusion therapy. Exercise preconditioning (EP) has been reported to facilitate brain function recovery. We aim to explore the specific mechanism of EP in CIRI.MethodsSprague‐Dawley rats were randomized into Sham, middle cerebral artery occlusion (MCAO), and EP groups (n = 11). The rats in the EP group received adaptive training for 3 days (10 m/min, 20 min/day, with a 0° incline) and formal training for 3 weeks (6 days/week, 25 m/min, 30 min/day, with a 0° incline). Then, rats underwent MCAO surgery to establish CIRI models. After 48 h, neurological deficits and cerebral infarction of the rats were measured. Neuronal death and apoptosis in the cerebral cortices were detected. Furthermore, RNA sequencing was conducted to investigate the specific mechanism of EP on CIRI, and qPCR and Western blotting were further applied to confirm RNA sequencing results.ResultsEP improved neurological deficit scores and reduced cerebral infarction in MCAO rats. Additionally, pre‐ischemic exercise also alleviated neuronal death and apoptosis of the cerebral cortices in MCAO rats. Importantly, 17 differentially expressed genes (DEGs) were identified through RNA sequencing, and these DEGs were mainly enriched in the HIF‐1 pathway, cellular senescence, proteoglycans in cancer, and so on. qPCR and Western blotting further confirmed that EP could suppress TIMP1, SOCS3, ANGPTL4, CDO1, and SERPINE1 expressions in MCAO rats.ConclusionEP can improve CIRI in vivo, the mechanism may relate to TIMP1 expression and HIF‐1 pathway, which provided novel targets for CIRI treatment.
Using evidence‐based decision‐making and cognitive apprenticeship approach to develop students' entrepreneurial mindset
Authors: Bosman Lisa , Magana Alejandra 
Published: July 2024

AbstractDeveloping one's entrepreneurial mindset is important for all students, regardless of discipline. Evidence‐based decision‐making (which has the potential to lower costs and improve quality of life) is one approach for applying entrepreneurially minded learning in the undergraduate classroom. This approach allows students to understand trends related to data, in general, and big data, specifically. Furthermore, it better prepares graduates to evaluate and identify effective data science‐based solutions. The purpose of this study is to report on one pedagogical approach to developing the entrepreneurial mindset through integrating evidence‐based decision‐making into the engineering and technology classroom using Microsoft Power BI Desktop (a freely available tool released by Microsoft in September 2013, where “BI” implies Business Intelligence). A mixed methods assessment was conducted including a rubric to measure students' effectiveness in applying the entrepreneurial mindset and a metacognitive reflection to better understand student motivation, awareness of learning, and engagement. First, the rubric was applied, and students were categorized by performance group (e.g., high, mid, low). Second, each performance group was analyzed to identify themes within the reflections. Our findings suggest that students in the high‐performing group communicated overall high levels of motivation, while students in the low‐performing group shared overall moderate levels of motivation. The relationship between performance and motivation among students in the mid‐performing group was inconclusive. Findings from our study suggest that there may be a relationship between students' performance and motivation. The key study implications relate to the use of new literacies, such as technological literacy, data literacy, and human literacy, as practices for promoting the development of an entrepreneurial mindset. Our findings suggest that our approach was effective in accomplishing this goal, but there is also room for improvement. Lessons learned and recommendations are provided.
A qualitative study of stakeholders' experiences with and acceptability of a technology‐supported health coaching intervention (SHARE‐S) delivered in coordination with cancer survivorship care
Authors: Price Sarah N. , Houston Thomas K. , Sadasivam Rajani S. , Wentworth Stacy , Chandler Allison , Strahley Ashley , Kittel Carol , Balakrishnan Kavitha , Weaver Kathryn E. , Dellinger Rebecca , Puccinelli‐Ortega Nicole , Kong Jinhee , Cutrona Sarah L. , Foley Kristie L. , Sohl Stephanie J. 
Published: July 2024

AbstractPurposeHealthy cancer survivorship involves patients' active engagement with preventative health behaviors and follow‐up care. While clinicians and patients have typically held dual responsibility for activating these behaviors, transitioning some clinician effort to technology and health coaches may enhance guideline implementation. This paper reports on the acceptability of the Shared Healthcare Actions & Reflections Electronic systems in survivorship (SHARE‐S) program, an entirely virtual multicomponent intervention incorporating e‐referrals, remotely‐delivered health coaching, and automated text messages to enhance patient self‐management and promote healthy survivorship.MethodsSHARE‐S was evaluated in single group hybrid implementation‐effectiveness pilot study. Patients were e‐referred from the clinical team to health coaches for three health self‐management coaching calls and received text messages to enhance coaching. Semi‐structured qualitative interviews were conducted with 21 patient participants, 2 referring clinicians, and 2 health coaches to determine intervention acceptability (attitudes, appropriateness, suitability, convenience, and perceived effectiveness) and to identify important elements of the program and potential mechanisms of action to guide future implementation.ResultsSHARE‐S was described as impactful and convenient. The nondirective, patient‐centered health coaching and mindfulness exercises were deemed most acceptable; text messages were less acceptable. Stakeholders suggested increased flexibility in format, frequency, timing, and length of participation, and additional tailored educational materials. Patients reported tangible health behavior changes, improved mood, and increased accountability and self‐efficacy.ConclusionsSHARE‐S is overall an acceptable and potentially effective intervention that may enhance survivors' self‐management and well‐being. Alterations to tailored content, timing, and dose should be tested to determine impact on acceptability and outcomes.