bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updated perspectives on the contribution of the microbiome to the pathogenesis of mucositis using the MASCC/ISOO framework
Authors: Stringer Andrea M. , Hargreaves Benjamin M. , Mendes Rui Amaral , Blijlevens Nicole M. A. , Bruno Julia S. , Joyce Paul , Kamath Srinivas , Laheij Alexa M. G. A. , Ottaviani Giulia , Secombe Kate R. , Tonkaboni Arghavan , Zadik Yehuda , Bossi Paolo , Wardill Hannah R. 
Published: July 2024

AbstractAdvances in the treatment of cancer have significantly improved mortality rates; however, this has come at a cost, with many treatments still limited by their toxic side effects. Mucositis in both the mouth and gastrointestinal tract is common following many anti-cancer agents, manifesting as ulcerative lesions and associated symptoms throughout the alimentary tract. The pathogenesis of mucositis was first defined in 2004 by Sonis, and almost 20 years on, the model continues to be updated reflecting ongoing research initiatives and more sophisticated analytical techniques. The most recent update, published by the Multinational Association for Supportive Care in Cancer and the International Society for Oral Oncology (MASCC/ISOO), highlights the numerous co-occurring events that underpin mucositis development. Most notably, a role for the ecosystem of microorganisms that reside throughout the alimentary tract (the oral and gut microbiota) was explored, building on initial concepts proposed by Sonis. However, many questions remain regarding the true causal contribution of the microbiota and associated metabolome. This review aims to provide an overview of this rapidly evolving area, synthesizing current evidence on the microbiota’s contribution to mucositis development and progression, highlighting (i) components of the 5-phase model where the microbiome may be involved, (ii) methodological challenges that have hindered advances in this area, and (iii) opportunities for intervention.
Exploring the similarity relationships from the nondimensionalization of atmospheric turbulence
Authors: Liu Zihan , Zhang Hongsheng , Cai Xuhui , Song Yu 
Published: July 2024

AbstractNondimensionalization, a theoretical approach for establishing interconnections among parameters within a set of equations, has proven to be an effective tool for the analysis of atmospheric turbulence. By applying nondimensionalization to turbulence equations, a concise form of dimensionless turbulence functions can be obtained. This process also yields several dimensionless parameters, defined as combinations of characteristic scales. From the dimensionless tensor $${B}$$
B
and vector $${{\varvec{\beta}}}_{\theta}$$

β

θ

introduced in this study, the characteristic length scale, $${z}^{s}$$

z

s

, can be defined as an alternative of length scale in similarity theories. Using the data from observational station in Horqin Sandy Land, quantified verifications of similarity relationships are carried out. The dimensionless parameters derived from nondimensionalization is not only in accordance with traditional turbulence theories but also facilitate the derivation of relationships among other dimensionless parameters. This reveals new similarity relationships that supplement the Monin–Obukhov theory. Under conditions of flat terrain and steady motions, the new length scale gives rise to similarity relationships exhibiting “4/3” exponential and near-linear patterns, which are associated with turbulent transport. These results make it possible to obtain the turbulent fluxes directly from the statistics of meteorological elements, even in stable stratifications. Consequently, the method of nondimensionalization can be taken as a reference in parameterization schemes of turbulence and climate models, and is fruitful in prospect of further study on atmospheric turbulence.
Assessment of contamination, mobility and application of selected technology-critical elements as indicators of anthropogenic pollution of bottom sediments
Authors: Jabłońska-Czapla Magdalena , Grygoyć Katarzyna , Yandem George 
Published: July 2024

AbstractThe study investigates the potential of technology-critical elements (TCEs) in the bottom sediments of the Biała Przemsza River as indicators of anthropogenic activities. The mass fractions of TCEs: Ge, Ga, In, Tl, Sb and Te (and other elements) in the sediment were analysed by inductively coupled plasma mass spectrometry with the maximum mass fractions: 2.46, 25.6, 0.528, 27.7, 12.5 and 0.293 mg/kg, respectively. Distribution and identification of TCE sources were supported by statistical analysis (principal component analysis coupled with varimax rotation and hierarchical cluster analysis). Assessments of TCE contamination using the geoaccumulation index, pollution index, contamination factor, enrichment factor and the antimony-to-arsenic ratio highlighted the high contamination of bottom sediments by Sb, Ga, Tl, Cd, As, Zn, Pb and moderate contamination by Co, In and V. Distinct behaviour patterns were observed among TCEs, revealing Sb and Tl as potential indicators of Zn-Pb ore mining activities. Co, V, Ge and, to a lesser extent, Te emerged as promising indicators of coal and coal fly ash effluents. Sequential chemical extraction of TCEs showed that Sb, In and Tl had the highest mobility from sediments. The Risk Assessment Code calculations suggest, that in the Biała Przemsza River bottom sediments, there is an average risk of contamination by As, Tl and Mn. Soluble forms of Tl, Ge, Sb, Te and In were identified in descending order, indicating their bioavailability.
Occurrence and human risk assessment of pharmaceutically active compounds (PhACs) in indoor dust from homes, schools and offices
Authors: Royano Silvia , Navarro Irene , de la Torre Adrián , Martínez María Ángeles 
Published: July 2024

AbstractThis study investigates the current situation and possible health risks due to pharmaceutically active compounds (PhACs) including analgesics, antibiotics, antifungals, anti-inflammatories, psychiatric and cardiovascular drugs, and metabolites, in indoor environments. To achieve this objective, a total of 85 dust samples were collected in 2022 from three different Spanish indoor environments: homes, classrooms, and offices. The analytical method was validated meeting SANTE/2020/12830 and SANTE/12682/2019 performance criteria. All indoor dust samples except one presented at least one PhAC. Although concentration levels ranged from < LOQ to 18 µg/g, only acetaminophen, thiabendazole, clotrimazole, and anhydroerythromycin showed quantification frequencies (Qf %) above 19% with median concentrations of 166 ng/g, 74 ng/g, 25 ng/g and 14 ng/g, respectively. The PhAC distribution between dust deposited on the floor and settled on elevated (> 0.5 m) surfaces was assessed but no significant differences (p > 0.05, Mann–Whitney U-test) were found. However, concentrations quantified at the three types of locations showed significant differences (p < 0.05, Kruskal–Wallis H-test). Homes turned out to be the indoor environment with higher pharmaceutical concentrations, especially acetaminophen (678 ng/g, median). The use of these medicines and their subsequent removal from the body were identified as the main PhAC sources in indoor dust. Relationships between occupant habits, building characteristics, and/or medicine consumption and PhAC concentrations were studied. Finally, on account of concentration differences, estimated daily intakes (EDIs) for inhalation, ingestion and dermal adsorption exposure pathways were calculated for toddlers, adolescents and adults in homes, classrooms and offices separately. Results proved that dust ingestion is the main route of exposure, contributing more than 99% in all indoor environments. Moreover, PhAC intakes for all studied groups, at occupational locations (classrooms and offices) are much lower than that obtained for homes, where hazard indexes (HIs) obtained for acetaminophen (7%—12%) and clotrimazole (4%-7%) at the worst scenario (P95) highlight the need for continuous monitoring.
Flow analysis-solid phase extraction system and UHPLC-MS/MS analytical methodology for the determination of antiviral drugs in surface water
Authors: Mermer Karolina , Jas Emilia , Paluch Justyna , Woźniakiewicz Aneta , Woźniakiewicz Michał , Miśkowiec Paweł , Chocholouš Petr , Sklenářová Hana , Kozak Joanna 
Published: July 2024

AbstractAn automated flow analysis-solid phase extraction (FA-SPE) system and methodology of ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) analysis were developed for the determination of selected antiviral drugs (acyclovir, amantadine, rimantadine, and oseltamivir) in water samples. The proposed FA-SPE approach enables the integration of various extraction stages and elimination of the sample evaporation step and offers individual customisation of SPE parameters, inter alia sample, and eluate flow rate and volume. Using the developed FA-SPE procedure, e.g. a 100-fold preconcentration of the target analytes in 1 h was achieved. A method for chromatographic analysis was also developed to determine the selected antiviral drugs in combination with the use of the FA-SPE system. The developed FA-SPE UHPLC-MS/MS method was validated including the determination of linearity of analytical graphs, limits of detection (5.5–99.9 pg mL−1) and quantification (18.3–329.8 pg mL−1), intra-day (1.8–8.3%) and inter-day (3.0–9.2%) precision, recovery (95.6–105.3%), and matrix effects (− 12.9 to 13.2%). The proposed method was successfully applied to analyse tap, drinking, and river water samples, revealing the presence of amantadine at a concentration of 40.1 pg mL−1 in one sample. The environmental impact of the developed FA-SPE sample preparation procedure was also assessed using the AGREEprep metric tool and compared with five other literature methods, achieving the most sustainable outcome.
Graphical abstract
Hearing, listening, and learning: how bioeconomy triple helix clusters deal with uninvited societal input
Authors: Starke Jan R. , Metze Tamara A. P. , Candel Jeroen J. L. , Termeer Katrien J. A. M. 
Published: July 2024

AbstractPolicymakers in the European Union embrace collaborations of businesses, governments, and academia to develop a sustainable and circular bioeconomy. These so-called Triple Helix clusters aim to stimulate innovation and learning. However, Triple Helix collaborators also face conflicting perspectives on the desirability and directionality of the bioeconomy transition, either within a cluster or with societal actors affected by a cluster’s innovations. While previous Triple Helix research focussed on how to broaden the cluster collaboration towards a more inclusive range of actors to handle such contestations, we study how cluster partners deal with uninvited input from societal actors that do not form part of a cluster. We conceptualize this input as societal back talk and distinguish organizational hearing, listening, and learning capabilities to explore how back talk contributes to innovation in three bioeconomy clusters in the Netherlands, Germany, and Ireland. Our qualitative case study analysis is based on interview transcripts, newspaper articles, and policy and planning documents. Results indicate that collaborating partners generally do not hear uninvited back talk that fundamentally challenges their tacit beliefs, because partners focus on informing the public about what they consider techno-economic benefits of their projects. As a consequence, collaborators become ‘insiders’, which hinders listening to divergent problem definitions and alternative solutions of ‘outsiders’. Learning from uninvited back talk is therefore restricted to minor adjustments. To avoid innovative solutions remaining unexplored as a result of this discursive lock-in, Triple Helix collaborators must engage in hearing and listening to critical societal actors by establishing a reflective, two-directional dialogue.
D-dimer/high sensitive troponin I ratio is useful in predicting in-hospital mortality in pulmonary embolism patients
Authors: Urfalioglu Ahmet Burak , Altug Ertugrul , Cinar Hayri , Aksay Erdem , Yesiloglu Onder , Cakir Adem , Avsar Mustafa , Diken Ozlem Ercen , Guven Ramazan , Avci Akkan 
Published: July 2024

Abstract
Background
Pulmonary embolism requires careful differential diagnosis as it is associated with a wide range of symptoms that may suggest different diseases such as chest pain, shortness of breath and syncope. Since the disease can be fatal, especially in cases where right ventricular failure and hemodynamic instability develop, prognostic markers are great importance in terms of monitoring the patient during the treatment process.

Aim
We aimed in our study to compare the relationship between the ratio of D-dimer and High Sensitive Troponin T (HsTnT) values ​​with short-term mortality and to compare this relationship with Pulmonary Embolism Severity Index (PESI) scoring.

Method
Our study was conducted with patients who applied to the emergency department of our hospital between 01/01/2022 and 01/01/2023 and were definitively diagnosed with Pulmonary thromboembolism after their evaluation.
Findings.
The success of D-dimer/HsTroponin, D-dimer/CK-MB and troponin/D-dimer indices calculated from the laboratory test results of the cases in predicting mortality was examined, and a comparison was made with the success of the PESI score in predicting mortality. Among these indices, D-dimer/CK-MB was found to be the most successful index in predicting 7-day mortality (AUC: 0.734; 95% CI: 0.653–0.815; p < 0.001). Additionally, the D-dimer/HsTroponin ratio was found to be statistically significant as a successful index in predicting 7-day mortality (AUC: 0.697; 95% CI: 0.621–0.774; p < 0.001).

Conclusion
FD-dimer/HsTroponin ratio, which is a powerful, fast, low-cost, easy and simple test, can be used especially in emergency services instead of the PESI score as a mortality marker in pulmonary embolism, which has a high mortality rate.
Investigating a Train-the-Trainer Model of Supervision and Peer Review for Child Interviewers in Canadian Police Services
Authors: Brubacher Sonja P. , Kirkland-Burke Meredith , Gates Valarie , Powell Martine B. 
Published: July 2024

AbstractThis project, conducted in one Canadian province, investigated whether a train-the-trainer model of supervision and peer review could improve the interviewing skills of police officers new to interviewing children. At 6 police services, 2 “interview specialists” were chosen by criteria (e.g. having conducted > 30 interviews with children), commitment (minimum 2 years to project), and performance evaluation of a mock and field interview. Specialists received additional training on leading group peer review and individual supervision. They carried out these activities over a 9-month period with 3–4 trainees (new interviewers) per site. Trainees’ interview performance was evaluated with mock and field interviews pre and post intervention. Qualitative interviews about project feasibility were carried out with the specialists at the end of the project, and the results of those interviews comprise the focus of this paper. At the time of the qualitative interviews, only 9 specialists and 5 sites remained in the project. Their interviews revealed that organizational buy-in was critical theme. Other emergent themes were that (different) training is needed for all levels of interviewing experience including interview specialists, that peer review formats are not one-size-fits-all across services, and that fostering a culture of peer review enhances cohesion.
First-principle calculations of magnetic properties of Ho6(Fe, Mn)Bi2 compounds
Authors: Garcia-Adeva Angel J. , Apiñaniz Estibaliz , Herrero Aritz , Aseguinolaza Ivan R. , Oleaga Alberto 
Published: July 2024

AbstractThe magnetic properties of Ho6MnBi2 and Ho6FeBi2 crystals are investigated by means of density functional theory. These materials are currently an active subject of research in the context of magnetic refrigeration applications since they exhibit a remarkable magnetocaloric effect. In this work, the equation of state, density of states and magnetic moments are calculated and compared with previous experimental results for these materials. Also, the Curie temperatures for the paramagnetic to ferromagnetic phase transition observed in these systems are calculated from first principles. All the calculated quantities are in reasonable agreement with experimental data, which suggests that density functional theory could provide a reliable framework to theoretically investigate the magnetic properties of intermetallic ternary compounds.
Graphical abstract
CircSorbs1 regulates myocardial regeneration and reduces cancer therapy-related cardiovascular toxicity through the Mir-99/GATA4 pathway
Authors: Huang Kang , Huang Denggao , Li Qiang , Zeng Jiangting , Qin Ting , Zhong Jianghua , Zhong Zanrui , Lu Shijuan 
Published: July 2024

AbstractDue to the cancer therapy-related cardiovascular toxicity, heart failure following cancer therapy has a significant mortality rate. Gene-targeted therapy promotes the re-entry of existing cardiomyocytes into the cell cycle to achieve myocardial regeneration, which is a promising strategy for preventing and treating heart failure after myocardial infarction. Circular RNAs (circRNAs) are considered as potential targets for myocardial regeneration due to their strong stability, resistance to degradation, and potential role in heart development and cardiovascular diseases. By comparing the myocardial tissue of mice in the sham operation group and the Doxorubicin therapy group (DOX), we observed a significant decrease in Cirsorbs expression in the DOX group. Cirsorbs was predominantly localized in cardiomyocytes and exhibited high conservation. Subsequent investigations revealed that Cirsorbs could promote myocardial proliferation and inhibit myocardial apoptosis. Mechanistic studies further demonstrated that Cirsorbs could bind to miR99 and reduce its expression level. Meanwhile, miR99 was found to bind to GATA4 mRNA and decrease its expression level. The binding of Cirsorbs to miR99 alleviated the repression of miR99, thereby enhancing GATA4 expression and the transcription of downstream cyclin A2 and cyclin E1. This, in turn, increased cardiomyocyte proliferation and reduced apoptosis. In conclusion, Cirsorbs holds promise as an effective target for myocardial regeneration in reducing cancer therapy-related cardiovascular toxicity.
Prognostic value of fibrinogen change value in adrenocortical carcinoma patients
Authors: Ma Chengquan , Yang Bin , Mao Quanzong 
Published: July 2024

Abstract
Purpose
The aim was to explore the preoperative and postoperative fibrinogen changes value (FCV) as a prognosis biomarker for in patients with adrenocortical carcinoma (ACC).

Methods
We identified 42 patients with ACC and 190 patients with adrenal adenoma (AA) who underwent surgery at our institution between 2015 and 2023. Preoperative fibrinogen, postoperative fibrinogen and follow-up information of the patients were recorded and analysed. The relationship between FCV and overall survival (OS)/ relapse-free survival (RFS) was evaluated.

Results
The mean level of preoperative and postoperative fibrinogen for ACC were 4.00 ± 1.64 g/L and 2.75 ± 0.59 g/L, respectively (p < 0.001). The mean level of preoperative and postoperative fibrinogen for AA were 2.79 ± 0.59 g/L and 2.71 ± 0.58 g/L, respectively (p = 0.144). In ACC, the lower FCV (≤ 1.25 g/L) showed a significantly poorer RFS than the higher (> 1.25 g/L) (p = 0.007); however, the lower FCV (≤ 1.25 g/L) showed no poorer OS than the higher (> 1.25 g/L) (p = 0.243). On multivariate survival analyses, FCV remained a predictor of RFS (HR 3.138).

Conclusion
According to the data in this study, it can be said that FCV is correlated with prognosis of ACC. The FCV might be a new biomarker for predicting the RFS of ACC.
Advanced Microfluidic Platform for Tumor Spheroid Formation and Cultivation Fabricated from OSTE+ Polymer
Authors: Panuška Petr , Smejkal Jiří , Štofik Marcel , Žmudová Zuzana , Španbauerová Klára , Havlica Jaromír , Harrandt Václav , Vinopal Stanislav , Aubrecht Petr , Malý Jan 
Published: July 2024

AbstractIn the evolving landscape of cancer research, 3D cell cultures, particularly tumor cell spheroids, are increasingly preferred in drug screening due to their enhanced mimicry of in vivo tumor environments, especially in drug resistance aspects. However, the consistent formation of uniform spheroids and their precise manipulation remain complex challenges. Among various methodologies, droplet microfluidics emerges as a highly effective approach for tumor spheroid formation. This paper introduces a novel, multifaceted microfluidic system that streamlines the entire spheroid cultivation process: (i) generating tumor spheroids from cell suspensions within individual droplets, (ii) merging these droplets into a continuous aqueous phase once spheroid formation is complete, and (iii) transferring the spheroids to a specialized cultivation area within the chip, equipped with trapping elements for extended cultivation in perfusion mode. Remarkably, this process requires no hydrogel encapsulation or external handling, as all operations are conducted within the microfluidic chip. Fabricated from the innovative OSTE+ (off-stoichiometry thiol-ene epoxy) polymer, the chip is designed for repeated use. To show its efficacy, we successfully formed spheroids from MCF-7, GAMG, and U87 cell lines in our system and compared them with spheroids prepared by a traditional agarose microwell method. Additionally, our methodology has successfully enabled the in-chip release of spheroids from droplets, followed by their effective trapping for subsequent cultivation, a process we have exemplified with MCF-7 spheroids. To our knowledge, this research represents the first instance of a fully integrated droplet microfluidic platform achieving scaffoldless tumor spheroid formation and handling. Our method holds promise for improving high-throughput, automated procedures in the formation, transfer, and cultivation of tumor cell spheroids.
Graphical abstract
Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations
Authors: Subudhi Rudra Narayan , Poonia Neelam , Singh Dilpreet , Arora Vimal 
Published: July 2024

AbstractUlcerative colitis (UC) is a recurring autoimmune disorder characterized by persistent inflammation in the mucosal lining of the lower part of the large intestine. Conventional treatment options such as salicylates, corticosteroids, and immunosuppressants often come with severe side effects, limited bioavailability, and the development of drug resistance, which hampers their therapeutic effectiveness. Therefore, it is imperative to explore natural strategies as safe and alternative treatments for UC. Currently, around 40% of UC patients find relief through natural constituents, which can help reduce toxic side effects and maintain clinical remission. This review aims to provide a summary of both preclinical and clinical evidence supporting the efficacy of various natural substances in the prophylaxis of UC. These natural options include plant extracts, essential oils, nutraceuticals, and phytochemicals. Furthermore, we will delve into the potential mechanisms that underlie the protective and curative actions of these novel herbal agents. In summary, this review will explore the effectiveness of natural remedies for UC, shedding light on their preclinical and clinical findings and the mechanisms behind their therapeutic actions. These alternatives offer hope for improved treatment outcomes and reduced side effects for individuals suffering from this challenging autoimmune condition.
Graphical Abstract