bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the performance of PV/diesel microgrids via integration of a battery energy storage system: the case of Bilgo village in Burkina Faso
Authors: Yamegueu Daniel , Nelson Henri Thomas , Boly Amidou Singho 
Published: August 2024

Abstract
Background
PV/diesel microgrids are getting more popular in rural areas of sub-Saharan Africa, where the national grid is often unavailable. Most of the time, for economic purposes, these hybrid PV/diesel power plants in rural areas do not include any storage system. This is the case in the Bilgo village in Burkina Faso, where a PV/diesel microgrid without any battery storage system has been set up. This power plant is composed of three diesel generators operating in parallel (two of 16 kW and one of 24 kW), coupled with a photovoltaic field of 30 kWp. It was observed that for such power plants, the grid management is not always efficient due to constantly fluctuating solar output and loads. This inconsistency in energy output raises the question if integrating battery energy storage systems could improve the grid's performance. While many studies in the literature focus on hybrid energy systems, only a few of them have tackled the optimization of existing and operational systems.

Methods
This study investigated three scenarios based on the existing microgrid's characteristics: conventional standalone diesel generators, PV/diesel without battery storage and PV/diesel with a battery storage system which are the main technologies used for off-grid rural electrification in Burkina Faso. The levelized cost of electricity (LCOE) was used to assess the economic performance of each scenario, and the calculations were made using the HOMER software.

Results
It was found that the best among the scenarios considered is the PV/diesel/battery configuration which has the lowest LCOE of US$ 0.524/kWh. The battery storage system for the optimal configuration has a capacity of 182 kWh with about 8 h of autonomy.

Conclusions
It can be inferred from this study that a storage unit is necessary for an optimal management of a PV/diesel microgrid. Indeed, the storage unit significantly reduces the operating and maintenance costs associated with running diesel generators, as well as the excess electricity. The storage system also allows for a greater reduction in CO2 emissions compared to systems without storage.
Overexpression of ESYT3 improves radioimmune responses through activating cGAS-STING pathway in lung adenocarcinoma
Authors: Luo Zan , Li Ying , Xu Bin , Yu Tenghua , Luo Mingming , You PeiMeng , Niu Xing , Li Junyu 
Published: August 2024

Abstract
Background
Radiotherapy can modulate systemic antitumor immunity, while immune status in the tumor microenvironment also influences the efficacy of radiotherapy, but relevant molecular mechanisms are poorly understood in lung adenocarcinoma (LUAD).

Methods
In this study, we innovatively proposed a radiotherapy response classification for LUAD, and discovered ESYT3 served as a tumor suppressor and radioimmune response sensitizer. ESYT3 expression was measured both in radioresistant and radiosensitive LUAD tissues and cells. The influence of ESYT3 on radiotherapy sensitivity and resistance was then investigated. Interaction between ESYT3 and STING was evaluated through multiple immunofluorescent staining and coimmunoprecipitation, and downstream molecules were further analyzed. In vivo models were constructed to assess the combination treatment efficacy of ESYT3 overexpression with radiotherapy.

Results
We found that radioresistant subtype presented immunosuppressive state and activation of DNA damage repair pathways than radiosensitive subtype. ESYT3 expression was remarkably attenuated both in radioresistant LUAD tissues and cells. Clinically, low ESYT3 expression was linked with radioresistance. Overexpression of ESYT3 enabled to alleviate radioresistance, and sensitize LUAD cells to DNA damage induced by irradiation. Mechanically, ESYT3 directly interacted with STING, and activated cGAS-STING signaling, subsequently increasing the generation of type I IFNs as well as downstream chemokines CCL5 and CXCL10, thus improving radioimmune responses. The combination treatment of ESYT3 overexpression with radiotherapy had a synergistic anticancer effect in vitro and in vivo.

Conclusions
In summary, low ESYT3 expression confers resistance to radiotherapy in LUAD, and its overexpression can improve radioimmune responses through activating cGAS-STING-dependent pathway, thus providing an alternative combination therapeutic strategy for LUAD patients.
Lejja archaeological site, Southeastern Nigeria and its potential for archaeological science research
Authors: Eze-Uzomaka Pamela Ifeoma , Ngonadi Chioma Vivian , Opata Christian Chukwuma , Ngonadi John Uche 
Published: August 2024

Abstract
In 2017/2018, two seasons of archaeological surveys were undertaken in Lejja, southeastern Nigeria. The aim of the archaeological field work was to systematically sample the area to locate archaeological sites, scatters of artefacts, features; and to characterize and record these findings. A particular objective was to identify sites with different typological or chronological characteristics and to then select representative examples for further investigation and excavations. This paper thus focuses for the first time; on the general knowledge of the archaeological signatures in addition to iron working that abound at the Lejja site from an archaeological perspective. We aimed to identify sites with evidence of iron production and sites with other characteristics of human habitation to compare inter-site variation. Using ethnoarchaeological studies, archaeological surveys and excavations, sixteen new sites were identified stretching from iron smelting sites to domestic/habitation sites and ancestral sites. We utilized both a systematic transect and an opportunistic approach to locate and map the archaeological sites encountered. The focus of the study was on thirteen key villages in Lejja southeastern Nigeria. Analysis of data shows that there seem to be distinct areas on the landscape for habitation and metal working respectively. However, it is unclear as yet what this distinction represents in terms of social organization, particularly whether they represent one community with different activity sites or two communities with distinct identities or indeed a more complex temporal and spatial patterning.
Origin of the 30–60-day intraseasonal oscillation of streamflow in source region of Yellow River in China: a perspective of the atmospheric signals from mid-high latitude
Authors: Li Lun , Zhu Congwen , Xu Xiangde , Zheng Ziyan , Ma Shuangmei , Sun Wanyi 
Published: August 2024

AbstractStreamflow in source region of Yellow River (SRYR) matters with regard to the adjacent and downstream water resources. Intraseasonal oscillation (ISO) in the streamflow in SRYR is of great significance to the sub-seasonal prediction of streamflow in SRYR, but is unknown. Here, we first report a 30–60-day ISO in the streamflow in SRYR, which is regulated by the atmospheric 30–60-day ISO at mid-high latitude over North Eurasia. The 30–60-day ISO in atmosphere is featured by a Rossby wavetrain, and the wave energy propagates southward onto the TP, which causes anomalous wind response over TP. The leading anomalous high (low) with anti-cyclonic (cyclonic) wind anomalies over the TP favors dry (wet) air in lower troposphere in SRYR, via enhancing the water vapor divergence (convergence). Dry (wet) air always results in strong (weak) evaporation from the Yellow River, which causes the later streamflow valley (peak) and thereby the 30–60-day ISO in the streamflow in SRYR.
NHEJ and HDR can occur simultaneously during gene integration into the genome of Aspergillus niger
Authors: Fritsche Susanne , Reinfurt Aline , Fronek Felix , Steiger Matthias G. 
Published: August 2024

AbstractNon-homologous end joining (NHEJ) and homology-directed repair (HDR) are two mechanisms in filamentous fungi to repair DNA damages. NHEJ is the dominant response pathway to rapidly join DNA double-strand breaks, but often leads to insertions or deletions. On the other hand, HDR is more precise and utilizes a homologous DNA template to restore the damaged sequence. Both types are exploited in genetic engineering approaches ranging from knock-out mutations to precise sequence modifications.In this study, we evaluated the efficiency of an HDR based gene integration system designed for the pyrG locus of Aspergillus niger. While gene integration was achieved at a rate of 91.4%, we also discovered a mixed-type repair (MTR) mechanism with simultaneous repair of a Cas9-mediated double-strand break by both NHEJ and HDR. In 20.3% of the analyzed transformants the donor DNA was integrated by NHEJ at the 3’ end and by HDR at the 5’ end of the double-strand break. Furthermore, sequencing of the locus revealed different DNA repair mechanisms at the site of the NHEJ event.Together, the results support the applicability of the genome integration system and a novel DNA repair type with implication on the diversity of genetic modifications in filamentous fungi.
Advancements in bandgap engineering: bromide-doped cesium lead perovskite thin films
Authors: Fradi Khawla , Bouich Amal , Khattak Yousaf Hameed , Baig Faisal , Slimi Bechir , Soucase Bernabé Marí , Chtourou Radhouane 
Published: August 2024

AbstractPerovskite materials have emerged as promising candidates for next-generation photovoltaic devices due to their unique optoelectronic properties. In this study, we investigate the incorporation of bromine into cesium lead mixed iodide and bromide perovskites (CsPbI3(1-x)Br3x) to enhance their performance. By depositing films with varying bromine concentrations (x = 0, 0.25, 0.5, 0.75), we employ a combination of structural and optical characterization techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), UV–visible spectroscopy, and photoluminescence. Our analysis reveals that introducing bromine leads to structural modifications, influencing the perovskite films’ optical properties and energy gap. Specifically, we observe semiconductor behavior with a tunable energy gap controlled by the intercalation of bromine atoms into the CsPbI3 lattice. Furthermore, heat treatment induces phase transitions in the perovskite films, affecting their optical responses and crystalline quality. SCAPS-1D simulations confirm the improved stability and efficiency of bromine-doped CsPbI3 films compared to undoped counterparts. Our findings demonstrate that bromine incorporation facilitates the formation of highly crystalline perovskite films with reduced trap defects and enhanced carrier transport properties. These results underscore the potential of bromine-doped CsPbI3 perovskites as promising materials for high-performance photovoltaic applications, paving the way for further optimization and device integration.
An eight-year retrospective study on the clinical outcomes of laser surface-treated implants
Authors: Leesungbok Richard , Hong Sung Ok , Lee Suk-Won , Htay Phyo Ei Ei , Choi Joseph Junesirk , Park Jung Jin 
Published: August 2024

Abstract
Purpose
To retrospectively evaluate peri-implant bone loss and health status associated with the long-term use of laser surface-treated implants.

Methods
For control study, total of 23 titanium ASTM F136 grade 23 implants were placed in the edentulous molar area of the mandible. When the Implant Stability Quotient (ISQ) ≥ 70 and insertion torque value (ITV) ≥ 35–50 Ncm at the insertion site, an immediate provisional restoration was connected to the implant within a week after surgery. The definitive restorations were placed 2 months after surgery for all implants. 13 implants were immediately loaded, while 10 implants were conventionally loaded. For comparative study, Radiographs were taken from third years for and then annually for the subsequent eight years to monitor marginal bone loss.

Results
After eight year of implant installation, the average change in vertical bone loss was 0.009 mm (P < 0.001), while the average change in horizontal bone loss 8 year after implant placement was 0.026 mm (P < 0.001). The mean marginal bone loss was < 0.2 mm on average.

Conclusions
In this retrospective study, laser-treated implants exhibit a low rate of bone absorption around the implants.
Characteristics of CYP3A4-related potential drug-drug interactions in outpatients receiving prescriptions from multiple clinical departments
Authors: Matsuoka Rina , Akagi Shinsuke , Konishi Tomohiro , Kondo Masashi , Matsubara Hideki , Yamamoto Shohei , Izushi Keiji , Tasaka Yuichi 
Published: August 2024

Abstract
Background
Drug-drug interactions (DDIs) increase the incidence of adverse drug reactions (ADRs). In a previous report, we revealed that the incidence of potential DDIs due to the same CYP molecular species in one prescription exceeds 90% among patients taking six or more drugs and that CYP3A4 markedly influences the increase in the number of potential DDIs in clinical practice. However, the factors contributing to an increased number of potential DDIs in prescriptions from multiple clinical departments remain poorly clarified.

Methods
This observational study was performed at five pharmacies in Okayama Prefecture, Japan. Patients who visited these pharmacies from 11 April 2022 to 24 April 2022 were included, except those who had prescriptions only from a single clinical department. A stratified analysis was performed to determine the incidence of CYP3A4-related potential DDIs according to the number of drugs taken. Additionally, factors associated with an increase in the number of drugs involved in CYP3A4-related potential DDIs were identified using multiple linear regression analysis. In this study, potential DDIs for the prescription data subdivided by clinical department, containing two or more drugs, were used as control data.

Results
Overall, 372 outpatients who received prescriptions from multiple clinical departments were included in the current study. The number of drugs contributing to CYP3A4-related potential DDIs increased with an increase in the number of clinical departments. Notably, in cases taking fewer than six drugs, prescriptions from multiple clinical departments had a higher frequency of CYP3A4-related potential DDIs than those in prescriptions subdivided by clinical department. Multiple regression analysis identified "Cardiovascular agents", "Agents affecting central nervous system", and "Urogenital and anal organ agents" as the top three drug classes that increase CYP3A4-related potential DDIs.

Conclusion
Collectively, these results highlight the importance of a unified management strategy for prescribed drugs and continuous monitoring of ADRs in outpatients receiving prescriptions from multiple clinical departments even if the number of drugs taken is less than six.
Deep learning for Bitcoin price direction prediction: models and trading strategies empirically compared
Authors: Omole Oluwadamilare , Enke David 
Published: August 2024

AbstractThis paper applies deep learning models to predict Bitcoin price directions and the subsequent profitability of trading strategies based on these predictions. The study compares the performance of the convolutional neural network–long short-term memory (CNN–LSTM), long- and short-term time-series network, temporal convolutional network, and ARIMA (benchmark) models for predicting Bitcoin prices using on-chain data. Feature-selection methods—i.e., Boruta, genetic algorithm, and light gradient boosting machine—are applied to address the curse of dimensionality that could result from a large feature set. Results indicate that combining Boruta feature selection with the CNN–LSTM model consistently outperforms other combinations, achieving an accuracy of 82.44%. Three trading strategies and three investment positions are examined through backtesting. The long-and-short buy-and-sell investment approach generated an extraordinary annual return of 6654% when informed by higher-accuracy price-direction predictions. This study provides evidence of the potential profitability of predictive models in Bitcoin trading.
3D-printing inherently MRI-visible accessories in aiding MRI-guided biopsies
Authors: Wang Yanlu 
Published: August 2024

Abstract
Background
3D printers have gained prominence in rapid prototyping and viable in creating dimensionally accurate objects that are both safe within a Magnetic Resonance Imaging (MRI) environment and visible in MRI scans. A challenge when making MRI-visible objects using 3D printing is that hard plastics are invisible in standard MRI scans, while fluids are not. So typically, a hollow object will be printed and filled with a liquid that will be visible in MRI scans. This poses an engineering challenge however since objects created using traditional Fused Deposition Modeling (FDM) 3D-printing techniques are prone to leakage. Digital Light Processing (DLP) is a relatively modern and affordable 3D-printing technique using UV-hardened resin, capable of creating objects that are inherently liquid-tight. When printing hollow parts using DLP printers, one typically requires adding drainage holes for uncured liquid resin to escape during the printing process. If this is not done liquid resin will remain inside the object, which in our application is the desired outcome.

Purpose
We devised a method to produce an inherently MRI-visible accessory using DLP technology with low dimensional tolerance to facilitate MRI-guided breast biopsies.

Methods
By hollowing out the object without adding drainage holes and tuning printing parameters such as z-lift distance to retain as much uncured liquid resin inside as possible through surface tension, objects that are inherently visible in MRI scans can be created without further post-processing treatment.

Results
Objects created through our method are simple and inexpensive to recreate, have minimal manufacturing steps, and are shown to be dimensionally exact and inherently MRI visible to be directly used in various applications without further treatment.

Conclusion
Our proposed method of manufacturing objects that are inherently both MRI safe, and MRI visible. The proposed process is simple and does not require additional materials and tools beyond a DLP 3D-printer. With only an inexpensive DLP 3D-printer kit and basic cleaning and sanitation materials found in the hospital, we have demonstrated the viability of our process by successfully creating an object containing fine structures with low spatial tolerances used for MRI-guided breast biopsies.
Morphological and cytological assessments reveal pollen degradation causes pollen abortion in cotton cytoplasmic male sterility lines
Authors: Pei Qingyu , Liu Jinshan , Guo Chunping , Ma Xiaomei , Liu Xiaoyan , You Chunyuan , Lin Hairong , Li Zhibo , Zhao Ruihai , Zhu Bo , Wu Yuanlong , Pan Zhenyuan , Nie Xinhui 
Published: August 2024

Abstract
Background
Understanding the mechanism of male sterility is crucial for producing hybrid seeds and developing sterile germplasm resources. However, only a few cytoplasmic male sterility (CMS) lines of cotton have been produced due to several challenges, like inadequate variation of agronomic traits, incomplete sterility, weak resilience of restorer lines, and difficulty in combining strong dominance. Therefore, the morphological and cytological identification of CMS in cotton will facilitate hybrid breeding.

Results
Two F2 segregating populations of cotton were constructed from cytoplasmic male sterile lines (HaA and 01A, maternal) and restorer lines (HaR and 26R, paternal). Genetic analysis of these populations revealed a segregation ratio of 3:1 for fertile to sterile plants. Phenotypic analysis indicated no significant differences in traits of flower bud development between sterile and fertile plants. However, sterile plants exhibited smaller floral organs, shortened filament lengths, and anther atrophy on the flowering day in comparison with the fertile plants. When performed scanning electron microscopy (SEM), the two F2 populations revealed morphological variations in the anther epidermis. Cellular analysis showed no significant differences in pollen development before pollen maturation. Interestingly, between the pollen maturation and flowering stages, the tapetum layer of sterile plants degenerated prematurely, resulting in abnormal pollen grains and gradual pollen degradation.

Conclusion
The results of this study suggest that fertility-restoring genes are controlled by a single dominant gene. Sterile plants exhibit distinctive floral morphology, which is characterized by stamen atrophy and abnormal anthers. Pollen abortion occurs between pollen maturity and flowering, indicating that premature tapetum degradation may be the primary cause of pollen abortion. Overall, our study provides a theoretical basis for utilizing CMS in hybrid breeding and in-depth investigation of the dominant configuration of cotton hybrid combinations, mechanisms of sterility, and the role of sterile and restorer genes.
Nutritional compositions, microbial quality, bioactivities, and volatile compounds of a novel vinegar from wild edible mushroom, Russula delica Fr
Authors: Saithong Pramuan , Permpool Jirawut , Rattanaloeadnusorn Sukhan , Poompurk Pholsit , Khunnamwong Pannida , Lomthong Thanasak 
Published: August 2024

AbstractVinegar is commonly utilized in cooking and food preparation as a flavoring, preservative, and condiment. It can be made from various sources, including fruits, grains, and vegetables. This study produced vinegar from a wild edible mushroom, Russula delica Fr., using microwave-assisted enzymatic hydrolysis extraction. The nutritional composition, bioactivities, microbial quality, and volatile compounds were analyzed in the production process and final vinegar product. Sugar syrup as total soluble solids (TSS) and total phenolic content (TPC) were extracted from mushroom powder using commercial enzymes and yielded 5.60 ± 0.10°Brix and 7.01 ± 0.06 mg GAE/g substrate, respectively. The extracted syrup was rich in amino acids such as aspartic and glutamic acid, with glucose as the main type of sugar. Maximum alcohol content at 10.95 ± 0.21% (w/v) with 1.28 ± 0.23 mg GAE/mL TPC was obtained from Saccharomyces cerevisiae fermentation after 21 days, while highest acetic acid was obtained at 5.60 ± 0.42% w/v with 1.87 ± 0.14 mg GAE/mL of TPC content and 74.85 ± 1.24% of DPPH radical scavenging activity after surface fermentation using Acetobacter aceti TISTR 354. Thirteen volatile compounds, including acids, alcohols, and aldehydes, were found in the wild edible mushroom vinegar, contributing to the unique aroma of the product. This study presented the first report on the analysis of vinegar from a wild edible mushroom, R. delica Fr. which showed high nutritional value, antioxidant activity and volatile compounds, with the potential for future commercial production.
Graphical Abstract