bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical Applications for Pharmacists Using Mobile Devices
Authors: Aungst Timothy Dy 
Published: July 2013

BACKGROUND Mobile devices (eg, smartphones, tablet computers) have become ubiquitous and subsequently there has been a growth in mobile applications (apps). Concurrently, mobile devices have been integrated into health care practice due to the availability and quality of medical apps. These mobile medical apps offer increased access to clinical references and point-of-care tools. However, there has been little identification of mobile medical apps suitable for the practice of pharmacy. OBJECTIVE To address the shortage of recommendations of mobile medical apps for pharmacists in daily practice. DATA SOURCES Mobile medical apps were identified via the iTunes and Google Play Stores via the “Medical” app categories and key word searches (eg, drug information, medical calculators). In addition, reviews provided by professional mobile medical app review websites were used to identify apps. STUDY SELECTION AND DATA EXTRACTION Mobile medical apps were included if they had been updated in the previous 3 months, were available in the US, used evidence-based information or literature support, had dedicated app support, and demonstrated stability. Exclusion criteria included apps that were not available in English, had advertisement bias, used nonreferenced sources, were available only via an institution-only subscription, and were web-based portals. DATA SYNTHESIS Twenty-seven mobile apps were identified and reviewed that involved general pharmacy practice, including apps that involved drug references, clinical references, medical calculators, laboratory references, news and continuing medical education, and productivity. CONCLUSIONS Mobile medical apps have a variety of features that are beneficial to pharmacy practice. Individual clinicians should consider several characteristics of these apps to determine which are suitable to incorporate into their daily practice.
p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization
Authors: Keil René , Schulz Jenny , Hatzfeld Mechthild 
Published: July 2013

Abstract
P0071 is a member of a subfamily of armadillo proteins that also comprises p120-catenin (p120ctn), δ-catenin/NPRAP, ARVCF and the more distantly related plakophilins 1–3. These proteins share a conserved central domain consisting of a series of repeated motifs, the armadillo repeats, which is flanked by more diverse amino- and carboxy-terminal domains. P0071 and the related proteins were first described as components of adherens junctions with a function in clustering and stabilizing cadherins, thereby controlling intercellular adhesion. In addition, these proteins show a cytoplasmic and a nuclear localization. Major progress in understanding their cytoplasmic role has been made in recent years. One common theme appears to be the spatiotemporal control of the small GTPases of the Rho family in various cellular contexts, such as cell adhesion and motility, cell division or neurite outgrowth. In this review article, we focus on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. Understanding p0071’s multiple functions requires assigning specific functions to particular binding partners and subcellular compartments. The identification of several new p0071 interacting proteins has promoted our understanding of the complex functions of this protein. Moreover, an initial analysis of its regulation begins to shed light on how these functions are coordinated in a cellular context.
Polyionic and cysteine-containing fusion peptides as versatile protein tags
Authors: Lilie Hauke , Richter Susanne , Bergelt Sabine , Frost Stefan , Gehle Franziska 
Published: July 2013

Abstract
In response to advances in proteomics research and the use of proteins in medical and biotechnological applications, recombinant protein production and the design of specific protein characteristics and functions has become a widely used technology. In this context, protein fusion tags have been developed as indispensable tools for protein expression, purification, and the design of functionalized surfaces or artificially bifunctional proteins. Here we summarize how positively or negatively charged polyionic fusion peptides with or without an additional cysteine can be used as protein tags for protein expression and purification, for matrix-assisted refolding of aggregated protein, and for coupling of proteins either to technologically relevant matrices or to other proteins. In this context we used cysteine-containing polyionic fusion peptides for the design of immunotoxins. In general, polyionic fusion tags can be considered as a multifunctional module in protein technology.
Trade-Off Analysis to Solve a Probabilistic Multi-Objective Problem for Passive Filtering System Planning
Authors: Carpinelli Guido , Ferruzzi Gabriella , Russo Angela 
Published: July 2013

Abstract
In recent years, modern distribution networks have rapidly evolved toward complex systems due to the increasing level of penetration of distributed generation units, storage systems, and information and communication technologies. In this framework, power quality disturbances such as waveform distortions should be minimized to guarantee optimal system behavior. This article formulates the planning problem of passive filtering systems in a multi-convertor electrical distribution system as a probabilistic multi-objective optimization problem whose input random variables are characterized with probability density functions. A heuristic simplified approach including trade-off analysis issues is applied to solve the planning problem with the aim of optimizing several objectives and meeting proper probabilistic equality and inequality constraints. The approach is able to quickly find solutions on the Pareto frontier that can help the decision-maker to select the final planning alternative for practical operation. The proposed approach is applied to a 17-busbar distribution test system to evidence its effectiveness.
Hypoglycemic activity of the Anisopus mannii N. E. Br. methanolic leaf extract in normal and alloxan-induced diabetic mice
Authors: Zaruwa Moses Z. , Manosroi Aranya , Akihisa Toshihiro , Manosroi Worapaka , Rangdaeng Samreung , Manosroi Jiradej 
Published: July 2013

Abstract
The hypoglycemic activities of nine sub-fractions from the methanolic leaf crude extract of Anisopus mannii were investigated in normoglycemic and alloxan-induced diabetic mice. The methanolic sub-fraction M at 400 mg/kg bw showed significantly (p<0.05) high reduction in fasting blood glucose (FBG) at 27.36 and 65.57% in normoglycemic and diabetic mice, respectively. In acute toxicity test, M at 2,000 and 5,000 mg/kg bw showed reduction in blood urea nitrogen and creatinine level, elevations in aspartate transaminase, alanine transaminase and total bilirubin levels, as well as the body weights. The weight-ratios of kidney and liver to the body weight of the mice fed with these doses of M were reduced with no sign of histopathological alteration. The M at 250 mg/kg bw significantly reduced the FBG levels in a postprandial study. The hypoglycemic effect of M was eliminated when co-administered with isosorbide dinitrate or nifedipine indicating the induction of insulin secretion via K+ ATP-dependent channels. The UV/HPLC analysis of M indicated saponin at 7.7 mg/g. This study confirmed the traditional use of A. mannii for diabetes mellitus and the potential for the further development as a novel hypoglycemic drug.
To Grow or Not to Grow: Nutritional Control of Development DuringCaenorhabditis elegansL1 Arrest
Authors: Baugh L Ryan 
Published: July 2013

AbstractIt is widely appreciated that larvae of the nematode Caenorhabditis elegans arrest development by forming dauer larvae in response to multiple unfavorable environmental conditions. C. elegans larvae can also reversibly arrest development earlier, during the first larval stage (L1), in response to starvation. “L1 arrest” (also known as “L1 diapause”) occurs without morphological modification but is accompanied by increased stress resistance. Caloric restriction and periodic fasting can extend adult lifespan, and developmental models are critical to understanding how the animal is buffered from fluctuations in nutrient availability, impacting lifespan. L1 arrest provides an opportunity to study nutritional control of development. Given its relevance to aging, diabetes, obesity and cancer, interest in L1 arrest is increasing, and signaling pathways and gene regulatory mechanisms controlling arrest and recovery have been characterized. Insulin-like signaling is a critical regulator, and it is modified by and acts through microRNAs. DAF-18/PTEN, AMP-activated kinase and fatty acid biosynthesis are also involved. The nervous system, epidermis, and intestine contribute systemically to regulation of arrest, but cell-autonomous signaling likely contributes to regulation in the germline. A relatively small number of genes affecting starvation survival during L1 arrest are known, and many of them also affect adult lifespan, reflecting a common genetic basis ripe for exploration. mRNA expression is well characterized during arrest, recovery, and normal L1 development, providing a metazoan model for nutritional control of gene expression. In particular, post-recruitment regulation of RNA polymerase II is under nutritional control, potentially contributing to a rapid and coordinated response to feeding. The phenomenology of L1 arrest will be reviewed, as well as regulation of developmental arrest and starvation survival by various signaling pathways and gene regulatory mechanisms.
Exegeses on Maximum Genetic Differentiation
Authors: Rousset François 
Published: July 2013

Abstract
A canon of population genetics concerns the properties of FST, a descriptor of spatial genetic structure. Interest for FST arose from Wright’s early insights linking FST to dispersal parameters as well as to his concept of effective population size (e.g., Wright 1938, 1951). Although there is continued interest in this topic, FST also serves in other applications, such as detecting selected markers in natural populations (Beaumont and Nichols 1996) and more often in routine descriptive works. Remarkably, it is the latter use that seems to attract most discussion. Alternative descriptors have been proposed. Conversely, attempts have been made to draw biological inferences from FST properties that do not depend on biological processes. A reconsideration of its properties under biological scenarios underlines the weaknesses of such approaches.
Comparison of Carboplatin- and Cisplatin-Based Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer Patients With Morbidity Risks
Authors: Nam Eun Ji , Lee Maria , Yim Ga Won , Kim Jae Hoon , Kim Sunghoon , Kim Sang Wun , Kim Jae Wook , Kim Young Tae 
Published: July 2013

Abstract

Purpose.
The aim of this study was to assess the activity and toxicity of primary carboplatin-based chemoradiotherapy (CarboRT) and to compare CarboRT with cisplatin-based chemoradiotherapy (CisRT) in patients with locally advanced cervical cancer and poor general condition.

Patients and Methods.
Fifty-one locally advanced cervical cancer patients with morbidity risks were prospectively enrolled between January 2007 and April 2010. Eligible patients received weekly intravenous CarboRT with carboplatin 100 mg/m2, and a comparison was made with a historical patient group that received weekly CisRT with cisplatin 40 mg/m2.

Results.
Median follow-up was 36 months (range: 4–66 months) in the CarboRT group and 53 months (range: 4–121 months) in the CisRT group. Compared with the historical CisRT group, the CarboRT group showed no statistically significant differences in recurrence (hazard ratio [HR], 1.21; 95% confidence interval [CI], 0.52–2.81) and survival (HR, 1.80; 95% CI, 0.49–6.54). The mean numbers of received cycles of CarboRT and CisRT were 7.5 ± 1.4 and 6.0 ± 1.8, respectively (p &lt; .001). The rates of grade 3–4 toxicity were similar in the two groups.

Conclusions.
CarboRT was better tolerated than CisRT without compromising tumor response and survival in patients with locally advanced cervical cancer and poor general condition.
Triple-Negative Breast Cancers: Associations Between Imaging and Pathological Findings for Triple-Negative Tumors Compared With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-2-Negative Breast Cancers
Authors: Boisserie-Lacroix Martine , MacGrogan Gaëtan , Debled Marc , Ferron Stéphane , Asad-Syed Maryam , McKelvie-Sebileau Pippa , Mathoulin-Pélissier Simone , Brouste Véronique , Hurtevent-Labrot Gabrielle 
Published: July 2013

Learning Objectives
Identify the features typical of triple-negative breast cancers on mammography, ultrasound, and magnetic resonance imaging. Identify this aggressive subtype to accelerate diagnosis and treatment and improve outcomes. Compare typical imaging features of triple-negative breast cancers with typical imaging features of HR+/HER- breast cancers.
Interventional Nephrology
Authors: Salman Loay , Beathard Gerald 
Published: July 2013

Summary
The prospective recognition of stenosis affecting dialysis vascular access and its prospective treatment is important in the management of the hemodialysis patient. Surveillance by physical examination is easily learned, easily performed, quickly done, and economical. In addition, it has a level of accuracy and reliability equivalent to other approaches that require special instrumentation. Physical examination should be part of any education to all hemodialysis care givers. This review presents the basic principles of physical examination of the hemodialysis vascular access and discusses the evidence behind its value.
Occupational exposure and lung cancer risk - Study in two different Romanian areas
Authors: Fildan P. , Dantes E. , Arghir O.C 
Published: July 2013

Abstract
Lung cancer is the most frequent neoplasm worldwide and the incidence in Constanta County is in continuous increasing. Occupation as a cause of lung cancer is common. The authors examined the relation between occupation and lung cancer in two patient cohorts from different areas of Romania: Constanta and Valcea. In 2005-2010, in Constanta and Valcea counties, 488 and 344 incident lung cancer cases were enrolled. Lifetime occupational histories (industry and job title) were coded by using standard international classifications and were translated into occupations known (list A) or suspected (list B) to be associated with lung cancer. An exposure excess of 14.6% for patients from Constanta ever employed in occupations known to be associated with lung cancer (list A) was found, with the largest contributions from the oil refinery and shipbuilding industries No overall excess was found for list B with the exception of bus and truck drivers (men) and launderers and dry cleaners (women), in both groups of patients. These results indicate that past exposure to occupational carcinogens remains an important determinant of lung cancer occurrence.
Myxoid liposarcoma with gastric localisation – Case Report
Authors: Boşoteanu Mădălina , Boşoteanu C. , Deacu Mariana , Aşchie Mariana 
Published: July 2013

Abstract
Liposarcoma is the most common malignant mesenchymal neoplasm affecting soft tissues and, less frequently, viscera. Gastric localisation of liposarcoma is extremely rare. We present the case of a 69-year-old female patient, who underwent subtotal gastrectomy with processing of the specimen in the Clinical Service of Pathology, Emergency County Hospital of Constantza. Histopathologically, the tumor exhibits a neoplastic population composed predominantly of lipoblasts in different stages of differentiation, with a massive disposition involving submucosa, muscularis and serosa. These cells contain intracytoplasmic small optically empty lipid vacuoles that produce indentations of centrally located nuclei; isolated lipoblasts have the appearance of signet ring cells. Predominant cellular population is admixed with scattered mature adipocytes and with stellate/spindled mesenchymal cells. Tumoral stroma has a myxoid character. A distinctive feature of this neoplasm is the existence of a vascular network composed of curved thin-walled capillaries with a branching pattern (“chicken-wire”). The histopathological traits and immunohistochemical profile of this tumor, characterized by positive reaction to Vimentin and S100 and negative staining to pancytokeratin, support the diagnosis of myxoid liposarcoma. The rare incidence of this tumor in the stomach requires a careful microscopical examination, in order to differentiate it from other clinico-pathological entities and to apply an appropriate therapy with a proper monitoring protocol.
Researching Elements of Cross-Border Social Cohesion: the Case of Slovene Border Areas
Authors: Bufon Milan 
Published: July 2013

AbstractThe article discusses the possibility of “measuring” the intensity of cross-border cohesion and co-dependence on the case of Slovene border areas. It presents first an overview of how geography has studied and interpreted borders, and what an impact had borders on both space and society. The author then analyses both qualitative and quantitative structure of border areas prior to Slovenia’s admission to the Schengen Space and explores recent changes after 2007, when border controls on the major part of his borders where eliminated. These developments produced several spatial and social (re)integration trends that have been detected in the author’s analyses through some comparable research methods and indicators, permitting also to rank Slovenian border sections and individual sub-areas by the intensity and quality of their cross-border cohesion.
Cross-Border Co-Operation in the Euroregions at the Polish-Czech and Polish-Slovak Borders
Authors: Dołzbłasz Sylwia 
Published: July 2013

Abstract The paper deals with border regions in Poland, which are regarded as a specific type of peripheral areas. The aim of this paper was to assess the Polish-Czech and Polish-Slovak border cooperation at the local level and to compare it to the Polish- German border. The studies were based on the analysis of the microprojects qualified for implementation under the Microprojects Fund within INTERREG IIIA programmes. Particular emphasis was put on the type characteristic of the projects and institutional structure of beneficiaries. Moreover, the relationships between analysed features were studied. The spatial distribution of projects was also examined. The role of Euroregions in the process of cross-border co-operation implementation was described. The analysis of the microprojects was carried out for the Poland’s southern border and the western one, as well as for particular Euroregions.
A CNN based Hybrid approach towards automatic image registration
Authors: Arun Pattathal V. , Katiyar Sunil K. 
Published: July 2013

Abstract
Image registration is a key component of various image processing operations which involve the analysis of different image data sets. Automatic image registration domains have witnessed the application of many intelligent methodologies over the past decade; however inability to properly model object shape as well as contextual information had limited the attainable accuracy. In this paper, we propose a framework for accurate feature shape modeling and adaptive resampling using advanced techniques such as Vector Machines, Cellular Neural Network (CNN), SIFT, coreset, and Cellular Automata. CNN has found to be effective in improving feature matching as well as resampling stages of registration and complexity of the approach has been considerably reduced using corset optimization The salient features of this work are cellular neural network approach based SIFT feature point optimisation, adaptive resampling and intelligent object modelling. Developed methodology has been compared with contemporary methods using different statistical measures. Investigations over various satellite images revealed that considerable success was achieved with the approach. System has dynamically used spectral and spatial information for representing contextual knowledge using CNN-prolog approach. Methodology also illustrated to be effective in providing intelligent interpretation and adaptive resampling.
Vitamīnu satura izmaiņas pilngraudu rudzu maizes ražošanā / Changes in Vitamin Content during the Whole Grain Rye Bread Processing
Authors: Ozoliņa Vija , Kunkulberga Daiga 
Published: July 2013

Abstract
Whole grain rye bread is a historically rich item in Latvian culture, and Latvians are rightly proud of the rye bread tradition they have cultivated. Much international research has shown that regular intake of rye bread positively influences the consumer health. Latvia has a long history of rye bread preparation, but lacks information about changes in vitamin content during the manufacturing process - from the beginning of baking till the end product - bread. The aim of the study was to investigate the changes in vitamin content during the whole grain rye bread production process. The object of the research work: traditional Latvian whole grain rye bread, the dough of which is prepared with scald and natural yeast and then baked in a wood-fired clay oven. AOAC standard methods were used to determine the content of thiamine (B1 vitamin), riboflavin (B2 vitamin), niacin (B3 vitamin), and α-tocopherol (E vitamin). The content of vitamins was analyzed in whole grain rye flour, leavened rye flour dough, and rye bread baked for 30, 45, 60 and 75 minutes. Bread crust and crumb were analyzed separately. The content of B complex vitamers in whole grain rye flour and bread was determined using LC-MS combined with stable isotope dilution assay. The study showed that whole grain rye bread contains a wide range of B complex vitamins. During the whole grain rye bread processing it was observed that, compared to vitamin content in flour, thiamine content reduced by 36%, but content of riboflavin, niacin and α-tocopherol increased by 53%, 40% and 6% respectively.
Rapšu eļļas degvielas patēriņa un izmešu emisijas pētījumi, iesmidzinot ūdens–bioetanola maisījumu motora ieplūdes sistēmā / The Rapeseed Oil Fuel Consumption and Exhaust Emissions Research Injecting a Water–Bioethanol Blend in the Engine Intake System
Authors: Birkavs Aivars , Dukulis Ilmārs , Birzietis Gints 
Published: July 2013

AbstractA research on the NOxreduction potential in diesel engine emissions injecting a 50% water-bioethanol blend in the engine intake system was carried out. Experiments were conducted on the test bench equipped with an Opel 16 DA four-cylinder 1.6-litre diesel engine and a two-tank system to run the engine on rapeseed oil. Toxic emissions were estimated using AVL SESAM FTIR multicomponent exhaust gas analytical system; the fuel consumption was measured using Kern 440-49A electronic weighing system. Three repetitions at the 1500 min-1and 2500 min-1engine crankshaft rotational speeds were performed; duration of each repetition - 120 seconds. Investigation results showed that such approach can reduce the nitrogen oxide content in exhaust gases by 32%, without significantly affecting other toxic emissions, at the same time reducing fuel consumption by 16-21%. Both rapeseed oil fuel and additive WE50 were derived from renewable resources, which plays an important role in elimination of climate changes.