bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new view on estimating China's capital flight through the travel channel
Authors: Wang Wei , Wen Yun , Xu Zitong , Yang Haoxi 
Published: August 2024

AbstractThis paper proposes a novel approach to quantitatively estimating the magnitude of China's capital flight through the travel channel from 2014 to 2019. We set 2014 as the break point to account for a change in the methodology of compiling outbound travel expenditure and adopt a counterfactual method to calculate the magnitude of China's capital flight through the travel channel. Our results show that, from 2014 to 2019, China's capital flight through the travel channel reached a total of US$602 billion, with a quarterly average of about US$25 billion, accounting for about 40% of the total Chinese outbound travel expenditure. We further construct a gravity model using data from the United Nations' World Tourism Organisation to empirically show that China's capital flight tends to flow to economies with a high degree of financial development and often appears when the RMB depreciates against the US dollar.
Optimal Drop Heights for Determining Reactive Strength Performance in Youth—Is 1 Drop Height Sufficient to Generate Trustworthy Conclusions for Training Practice?
Authors: Keiner Michael , Möck Sebastian , Hartmann Hagen , Wirth Klaus 
Published: August 2024

This study critically examines the suitability of using a single drop height to assess the reaction strength index in trained and active participants, a key component of athletic performance. Using a cross-sectional design, 377 trained (n = 163) and active (n = 214) participants aged 14–18 years performing drop jumps from 4 different heights (24, 32, 40, and 48 cm) were studied. The primary aim was to explore the individual differences in reaction strength index at these heights and to assess whether a single height can reliably represent stretch-shortening cycle capabilities. While the repeated measures analysis of variance did not reveal any significant differences, the Bland–Altmann analysis revealed significant individual discrepancies between the performance of the drop heights, resulting in a mean absolute error of 32.1 and a mean absolute percentage error of 20.6%. These results strongly suggest that a single drop height is not sufficient to determine performance in the stretch-shortening cycle. This has important practical implications as it can lead to underestimates of performance trends. The study advocates the inclusion of a range of drop heights in routine testing to accurately measure reactive power and thus improve the effectiveness of individualized training programs for young athletes/active youth.
Choosing Wisely in oncology: are guidelines effective at preventing unnecessary diagnostics? The example of surveillance positron emission tomography for patients with localised colorectal cancer
Authors: Goldstein Daniel A , Tschernichovsky Roi , Razi Talish , Filosof Keren , Menashe Idan , Arbel Ronen , Netzer Doron 
Published: August 2024

ObjectiveHealthcare overuse is a major challenge for healthcare systems and patients worldwide. Professional guidelines such as the ‘Choosing Wisely’ guidelines have attempted to reduce specific examples of overuse. We examined the use of surveillance positron emission tomography CT (PETCT) in patients with colorectal cancer (CRC) treated with curative intent.Methods and analysisWe used the large Clalit Health Services dataset in Israel to identify patients with CRC who received adjuvant chemotherapy between January 2017 and December 2021. We examined the number of PETCTs performed for each patient.ResultsWe included 1799 patients in our study cohort. We distinguished localised from metastatic cases based on specific drugs administered or not administered during the follow-up period (ie, biologics). For the entire cohort, the median number of PETCTs performed per patient over the study period was 3364 (20.2%) patients underwent a single PETCT, 946 (52.6%) patients underwent ≥2 PETCTs and 25 patients underwent ≥10 PETCTs. If none or a single PETCT is considered ‘guideline-concordant’ during diagnosis and treatment of localised CRC, 69% of 4231 PETCTs performed were ‘guideline-discordant’.ConclusionDespite the professional guidelines recommending against routine PETCT to monitor for recurrence following curative-intent treatment of CRC, there remains a large volume of guideline-discordant PETCTs, constituting healthcare overuse of an expensive diagnostic procedure.
Longitudinal change in cardiorespiratory fitness and the association with cardiovascular disease and all-cause mortality in young Asian men: a cohort study
Authors: Gorny Alexander Wilhelm , Prakaash Suriya , Neo Jia Wei , Chow Weien , Yeo Khung Keong , Yap Jonathan , Müller-Riemenschneider Falk 
Published: August 2024

Introduction
Cardiorespiratory fitness (CRF) in young adulthood is a determinant of chronic disease risk. To better understand whether CRF might also behave as a modifiable risk factor, we examined the associations between longitudinal changes in 2.4 km run times and health outcomes in a cohort of healthy young men.

Methods
Our dataset comprised individual run times and health outcomes captured in four national registries. Cox proportional hazards models were used to examine the association between baseline run times and relative hazards of first major adverse cardiovascular events (MACE) and all-cause mortality (ACM). Relative hazards associated with longitudinal change in run times were estimated using models that were adjusted for run-time at baseline.

Results
The study sample comprised 148 825 healthy men ages 18–34 years who had undergone at least two routine fitness tests that were 5–9 years apart. During 1 294 778 person-years of follow-up, we observed 1275 first MACE and 764 ACM events occurring at mean ages of 43.2 (SD 6.0) years and 39.2 (SD 6.6) years, respectively. A 1% increase in run-time per annum was associated with a 1.13 (95% CI 1.10 to 1.16) times greater hazard of first MACE and a 1.06 (95% CI 1.02 to 1.10) times greater hazard of ACM. The association between longitudinal change in run times and first MACE was preserved in sensitivity analyses using models adjusted for body mass index at baseline.

Conclusion
Among men under the age of 35 years, longitudinal change in run times was associated with the risk of cardiovascular disease two decades onwards.
Epidemiology and clinical profile of sports injuries treated in the Douala General and Laquintinie Hospitals, in Cameroon
Authors: Tankeng Leonard Tanko , Ngatchou Djomo William , Nana Theophile Chunteng , Akwa Gilbert Mua , Mbianyor Bill-Erich , Lifafa Kinge Kange , Bonny Aimé 
Published: August 2024

ObjectivesTo describe the epidemiological patterns and clinical characteristics of sports injuries treated at two hospitals in Douala.MethodsThis was a cross-sectional study conducted at the Douala General Hospital and Douala Laquintinie Hospital, involving medical records of patients treated for sports injuries from January 2012 to April 2022. Data extracted from records were entered into a data collection software and analysed using Microsoft Excel 2016. Severe injuries were defined as an injury score greater than or equal to 3 on the Abbreviated Injury Scale.ResultsThe prevalence of sports injuries was 1.12% among all trauma cases. There was a male predominance with 62 (86.1%) males and 10 (13.9%) females. The mean age was 24.97±13.8 years. Most injured persons were students 35 (48.6%), followed by the employed 26 (36.1%), athletes 6 (8.3%) and the unemployed 5 (6.9%). Recreational sports accounted for 43 (59.7%) injuries while 16 (22.2%) injuries occurred during physical education, 8 (11.1%) during trainings and 5 (6.9%) during competitions. Football injuries were 48 (66.7%), running injuries 10 (13.9%) and 9 (12.5%) occurred during long, high and triple jump. Among all injuries, fractures were 43 (59.7%), 11 (15.3%) joint sprains, 5 (6.9%) muscle injuries, 4 (5.6%) brain injuries while 9 (12.5%) were contusions and lacerations. Lower extremity injuries were 34 (47.2%), 21 (29.2%) injuries were on the upper extremities, 4 (5.6%) abdominopelvic, 3 (4.2%) thoracic injuries, 9 (12.5%) head injuries and 1 (1.4%) on the neck. Overall, 53 (73.7%) were severe injuries.ConclusionThe majority of sports injuries treated in these hospitals are fractures that occur during recreational sports, particularly football and predominantly involve the lower extremity. A significant proportion are severe injuries.
Public support for logbooks during the supervised practice driving phase of graduated driver licensing: a national survey of teens and parents in the USA
Authors: Ehsani Johnathon P , Duren Michelle L , Hellinger Andrew , Sabit Ahmed 
Published: August 2024

BackgroundVerification of the completion of supervised practice driving hours for teenagers is challenging. Electronic logbooks could provide an objective alternative to paper logbooks. Factors influencing the adoption of electronic logbooks are poorly understood. We conducted a survey of a nationally representative sample of teenagers and parents in the USA to address these gaps in understanding.MethodsThe survey was fielded to teenagers who were currently learning to drive or had a full driver’s licence, and parents of teenager with a learner’s permit or a driver’s licence. We measured (1) support for supervised practice driving requirements and logbook requirements, (2) preferences between paper and electronic logbooks and (3) features that would make an electronic logbook useful.ResultsMost parents and teenagers supported both supervised practice driving and logbook requirements. The overwhelming majority of teenagers and parents preferred an electronic logbook over paper. Electronic logbooks that provide (1) summary information about completed drives, (2) parent certification of drives and (3) automatic trip detection were features that were rated most useful by respondents.DiscussionThis is the first study to measure teen and parent support for the logbook format to track supervised practice driving. Public support for electronic logbooks is high, suggesting that policy makers could consider adding an electronic logbook requirement to graduated driver licensing systems to objectively measure completed practice driving hours. Driver educators could also promote the use electronic logbooks to track practice and calibrate behind-the-wheel lessons to the amount of practice driving that has been completed.
Chronic challenges: picturing chronic disease by the World Health Organization
Authors: Medcalf Alexander , Atkin Karl 
Published: August 2024

Chronic diseases are among the leading causes of mortality in the world, the subject of major regional and international efforts to tackle shared risk factors, implement prevention and control measures and set national targets as part of the drive towards universal health coverage. Yet there is a growing conviction that chronic diseases suffer an image problem. It has been suggested that the terminology ‘dulls the senses' to the problems, and in an age where the mass media affords unprecedented opportunities to inform and persuade people to care about their health and that of others, chronic disease representation remains a contested and much debated issue.This article investigates how WHO created and disseminated visual narratives to raise popular consciousness and build a visual vocabulary around chronic disease in the second half of the 20th century. It examines the measures taken to conceptualise, photograph and publicise chronic diseases, and considers who had control over their representation. In focussing predominantly on cancer, diabetes and cardiovascular disease, it reveals different narratives; the power of scientific and technological progress; individual and community action for health; promising utopian and parallel dystopian visions. It embeds these in a production context which reveals an intricate picturing process involving overcoming challenges of representation. It uses this historical background to discuss issues relating to how chronic disease and chronic pain have been narrated visually, such as the ideas of emotional response, moral failure, how people navigate the ‘risk society’ and ultimately the concerns regarding the intentional and unintentional influence that the media can have on the image of disease given to society.
Effect of chemical modification on the distribution of electrophoretic mobilities of individual molecules of E. coli β-galactosidase
Authors: Riehl Brynne K. , Klassen Allyster B.T. , Abas Sumaiya , Pathak Winner , Craig Douglas B. 
Published: August 2024

Escherichia coli  β-galactosidase was labelled with 1 mmol/L fluorescein 5-carbamoylmethylthiopropanoic N-hydroxysuccinimidyl ester for 1 and 3 min. The samples were separated by capillary electrophoresis and peak areas compared to that of labelled BSA for the purpose of quantification of the concentration of attached label. Enzyme concentration in the samples was determined by single molecule counting. The average number of labels attached to each molecule of enzyme was found to be 3.1 and 4.5 when labelled for 1 and 3 min, respectively. The distribution of single enzyme molecule electrophoretic mobilities for the unlabelled enzyme and that labelled for 1 and 3 min were measured using capillary electrophoresis. The average mobilities were found determined to be −(1.99 ± 0.13) × 10–8 m2 V−1 s−1 ( N = 39), −(2.16 ± 0.19) × 10–8 m2 V−1 s−1 ( N = 46), and –(2.18 ± 0.21) × 10–8 m2 V−1 s−1 ( N = 39), respectively. A protein electrophoresis model was applied and predicted that the differences in average mobilities could be explained through relatively minor changes in overall charge, Stokes radius, and shape. This difference was similar to the range in mobilities observed in the unlabelled protein. This is consistent with the electrophoretic heterogeneity of the unmodified enzyme being caused by relatively small differences in charge, size, and shape of the individual molecules in the population.
NMSSM explanation for excesses in the search for neutralinos and charginos and a 95 GeV Higgs boson
Authors: Ellwanger Ulrich , Hugonie Cyril , King Stephen F. , Moretti Stefano 
Published: August 2024

AbstractThe observed excesses in the search for neutralinos and charginos by ATLAS and CMS can be fitted simultaneously in the minimal supersymmetric standard model (MSSM) assuming a light higgsino mass, of magnitude less than about 250 GeV, and a compressed higgsino dominated neutralino and chargino spectrum, with 5–10% mass splittings. However, light higgsinos as dark matter would have far too large direct detection cross sections. We consider the Next-to-MSSM (NMSSM) with an additional singlino-like lightest supersymmetric particle (LSP) a few GeV below the next-to-lightest supersymmetric particle (NLSP). Sparticles prefer to decay first into the NLSP and remnants from the final decay into the LSP are too soft to contribute to the observed signals. Co-annihilation in the higgsino-sector can generate a relic density in the WMAP/Planck window. The singlino-like LSP has automatically a direct detection cross section below present and future sensitivities: a direct detection signal in the near future would exclude this scenario. The singlet-like Higgs scalar of the NMSSM can have a mass around 95 GeV and signal cross sections in the $$b\bar{b}$$

b

b

¯

channel at LEP and in the $$\gamma \gamma $$

γ
γ

channel at the LHC compatible with the respective observations.
Two syenitic phases in the Early Paleogene Silhouette Island volcano-plutonic complex, Seychelles
Authors: Shellnutt J. Gregory , Lee Tung-Yi , Iizuka Yoshiyuki , Lee Hao-Yang , Suga Kenshi , Pham Chi Thi 
Published: August 2024

The Silhouette alkaline volcano-plutonic complex is the largest exposed Early Paleogene (62–64 Ma) igneous complex of the Seychelles microcontinent. The rocks of this study were collected from Baie Cipailles, Pte Vareur and Pte Ramasse Tout and include syenite (SiO
2
= 60–63 wt%), microgranite (SiO
2
= 70–74 wt%), tuffaceous trachyte (SiO
2
= 64–65 wt%) and a basaltic xenolith (SiO
2
= 44 wt%; MgO = 6.4 wt%; Mg# = 47.6). The silicic rocks of this study are ferroan, metaluminous to weakly peralkaline and classify as A1-type granitoids. The whole-rock Sr–Nd (
87
Sr/
86
Sr
i
= 0.703894–0.706534;

ε

Nd
(
t
) = +0.5–+1.8) isotopes of the silicic rocks are similar to those of the basalt xenolith (
87
Sr/
86
Sr
i
= 0.703576;

ε

Nd
(
t
) = +1.9). There is limited to no geochemical evidence for crustal contamination in any of the rocks. The syenitic rocks were probably derived by fractional crystallization of an alkaline basaltic parental magma in the upper crust and under reducing conditions (

Δ

FMQ = −1). The Sr–Nd isotopes and zircon Hf (

ε

Hf
(
t
) = +3.3–+9.1) isotopes of the silicic rocks are indicative of a moderately depleted source. We found distinct textural, mineralogical and compositional differences between the syenitic rocks, suggesting that the Silhouette complex is composed of at least two syenitic magma pulses.
Tyrosine Protein Kinase SYK-Related Gene Signature in Baseline Immune Cells Associated with Adjuvant Immunotherapy–Induced Immune-Related Adverse Events in Melanoma
Authors: Monson Kelsey R. , Ferguson Robert , Handzlik Joanna E. , Xiong Jiahan , Dagayev Sasha , Morales Leah , Chat Vylyny , Bunis Anabelle , Sreenivasaiah Chaitra , Dolfi Sonia , Tenney Daniel J. , Shao Yongzhao , Osman Iman , Weber Jeffrey S. , Kirchhoff Tomas 
Published: August 2024

Abstract

Purpose:
Immune checkpoint inhibition (ICI) shows benefits in adjuvant (AT) and neoadjuvant melanoma treatments. However, ICI frequently induces severe immune-related adverse events (irAE). Unlike metastatic disease, in which irAEs are a clinical trade-off for treatment that improves survival, the toxicity burden from ICI in the AT setting is a substantial clinical problem urging for irAE-predictive biomarkers.

Experimental Design:
We assessed postsurgical, pre–ICI treatment peripheral CD4+ and CD8+ T cells from clinical trial patients (CheckMate 915) treated with AT nivolumab (n = 130) or ipilimumab/nivolumab (COMBO, n = 82). Performing RNA sequencing differential gene expression analysis, we tested baseline differences associated with severe (grades 3–5) irAEs and constructed an irAE-predictive model using least absolute shrinkage and selection operator–regularized logistic regression.

Results:
The analysis of predicted protein–protein interactions among differentially expressed genes in peripheral CD4+ cells revealed significant enrichment of the spleen tyrosine kinase (SYK) pathway, associated with severe irAEs in COMBO-treated patients. This gene expression signature predicted severe-irAE COMBO patients (χ2P value = 0.001) with 73% accuracy and was independent of disease recurrence (P = 0.79). The irAE-predictive model incorporating this gene expression signature demonstrated 82% accuracy (χ2P value = 8.91E−06).

Conclusions:
We identified baseline gene expression differences in key immune pathways of peripheral blood T cells from COMBO-treated patients with grades 3 to 5 irAEs and defined a SYK-related gene signature correctly identifying ∼60% of COMBO-treated patients with grades 3 to 5 irAEs. This finding aligns with our previous work linking anti-CTLA4 irAEs with a germline variant associated with high SYK expression. This gene signature may serve as a baseline biomarker of severe grade 3 to 5 irAE risk, which is especially important in AT treatment.
Targeting the FGFR Pathway in Patients with Advanced Solid Tumors
Authors: Chehade Chadi Hage , Ozay Zeynep Irem , Agarwal Neeraj 
Published: August 2024

Summary
In the phase II FUZE trial targeting the FGFR pathway, Debio 1347 showed limited antitumor activity and manageable toxicity in patients with advanced solid tumors. Results from transcriptome-based analysis enhanced our understanding of the genomic landscape of FGFR fusion–driven tumors, informing clinical trial design and generating hypotheses for resistance mechanisms.
See related article by Grivas et al., p. 4572
Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
Authors: Xiang Xiaonan , Wang Kai , Zhang Hui , Mou Haibo , Shi Zhixiong , Tao Yaoye , Song Hongliang , Lian Zhengxing , Wang Shuai , Lu Di , Wei Xuyong , Xie Haiyang , Zheng Shusen , Wang Jianguo , Xu Xiao 
Published: August 2024

Abstract
The efficacy of immune checkpoint inhibitors in the treatment of hepatocellular carcinoma (HCC) remains limited, highlighting the need for further investigation into the mechanisms underlying treatment resistance. Accumulating evidence indicates that tumor-associated macrophages (TAM) within the tumor microenvironment demonstrate a key role in immune evasion and treatment resistance. This study explored the role of TAMs in the HCC tumor microenvironment. Our findings reveal that TAMs expressing CX3C motif chemokine receptor 1 (CX3CR1) induced T-cell exhaustion through IL27 secretion in orthotopic models of HCC following treatment with anti-PD1. Moreover, we identified prostaglandin E2 (PGE2), released by immune-attacked tumor cells, as a key regulator of TAM transition to a CX3CR1+ phenotype. To augment the therapeutic response to anti-PD1 therapy, we propose targeting CX3CR1+ TAMs in addition to anti-PD1 therapy. Our study contributes to the understanding of the role of TAMs in cancer immunotherapy and highlights potential clinical implications for HCC treatment. The combination of targeting CX3CR1+ TAMs with anti-PD1 therapy holds promise for enhancing the efficacy of immunotherapeutic interventions in patients with HCC.
Poor Prognosis among Radiation-Associated Bladder Cancer Is Defined by Clinicogenomic Features
Authors: Wijetunga N. Ari , Gessner Kathryn H. , Kanchi Krishna , Moore Jay A. , Fleischmann Zoe , Jin Dexter X. , Frampton Garrett M. , Sturdivant Michael , Repka Michael , Sud Shivani , Corcoran David L. , Galsky Matthew D. , Milowsky Matthew I. , Wobker Sara E. , Kim William Y. , Rose Tracy L. , Damrauer Jeffrey S. 
Published: August 2024

Abstract

Radiotherapy (RT) for prostate cancer has been associated with an increased risk for the development of bladder cancer. We aimed to integrate clinical and genomic data to better understand the development of RT-associated bladder cancer. A retrospective analysis was performed to identify control patients (CTRL; n = 41) and patients with RT-associated bladder cancer (n = 41). RT- and CTRL-specific features were then identified through integration and analysis of the genomic sequencing data and clinical variables. RT-associated bladder tumors were significantly enriched for alterations in KDM6A and ATM, whereas CTRL tumors were enriched for CDKN2A mutation. Globally, there were an increased number of variants within RT tumors, albeit at a lower variant allele frequency. Mutational signature analysis revealed three predominate motif patterns, with similarity to SBS2/13 (APOBEC3A), SBS5 (ERCC2/smoking), and SBS6/15 (MMR). Poor prognostic factors in the RT cohort include a short tumor latency, smoking status, the presence of the smoking and X-ray therapy mutational signatures, and CDKN2A copy number loss. Based on the clinical and genomic findings, we suggest at least two potential pathways leading to RT-associated bladder cancer: The first occurs in the setting of field cancerization related to smoking or preexisting genetic alterations and leads to the development of more aggressive bladder tumors, and the second involves RT initiating the oncogenic process in otherwise healthy urothelium, leading to a longer latency and less aggressive disease.

Significance:
Clinicogenomic analysis of radiation-associated bladder cancer uncovered mutational signatures that, in addition to a short tumor latency, smoking, and CDKN2A loss, are associated with a poor outcome. These clinical and genomic features provide a potential method to identify patients with prostate cancer who are at an increased risk for the development of aggressive bladder cancer following prostate RT.