bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a substrate of the renal tubular transporters for detecting drug-induced early acute kidney injury
Authors: Jin Yong-Wen , Ma Yan-Rong , Liu Yu-Ting , Yang Jin-Ru , Zhang Ming-Kang , Ran Feng-Lin , Chen Yang , Wu Xin-An 
Published: July 2024

Abstract
Early identification of drug-induced acute kidney injury (AKI) is essential to prevent renal damage. The renal tubules are typically the first to exhibit damage, frequently accompanied by changes in renal tubular transporters. With this in mind, we have identified an endogenous substrate of the renal tubular transporters that may serve as a biomarker for early detection of drug-induced AKI. Using gentamicin- and vancomycin-induced AKI models, we found that traumatic acid (TA), an end metabolite, was rapidly increased in both AKI models. TA, a highly albumin-bound compound (96% to 100%), could not be filtered by the glomerulus and was predominantly eliminated by renal tubules via the OAT1, OAT3, OATP4C1, and P-gp transporters. Importantly, there is a correlation between elevated serum TA levels and reduced OAT1 and OAT3 levels. A clinical study showed that serum TA levels rose before an increase in serum creatinine in 13 out of 20 AKI patients in an intensive care unit setting. In addition, there was a notable rise in TA levels in the serum of individuals suffering from nephrotic syndrome, chronic renal failure, and acute renal failure. These results indicate that the decrease in renal tubular transporter expression during drug-induced AKI leads to an increase in the serum TA level, and the change in TA may serve as a monitor for renal tubular injury.
Acute kidney injury (AKI) has a high clinical incidence, and if patients do not receive timely treatment and intervention, it can lead to severe consequences. During AKI, tubular damage is often the primary issue. Endogenous biomarkers of tubular damage are critical for the early diagnosis and treatment of AKI. However, there is currently a lack of reliable endogenous biomarkers for diagnosing tubular damage in clinical practice. Tubular secretion is primarily mediated by renal tubular transporters (channels), which are also impaired during tubular damage. Therefore, we aim to identify endogenous biomarkers of tubular damage from the perspective of renal tubular transporters, providing support for the early detection and intervention of AKI. TA is a substrate of multiple channels, including OAT1, OAT3, OATP4C1, and P-gp, and is primarily secreted by the renal tubules. In the early stages of rat AKI induced by GEN and VCA, serum TA levels are significantly elevated, occurring earlier than the rise in serum creatinine (SCr). Thus, TA is expected to become a potential endogenous biomarker for the early diagnosis of tubular damage.
Sex hormone deprivation abolishes sex‐specific differences in murine colon inflammation and related lipid mediator production
Authors: Pace Simona , Meyer Katharina Paula Lydia , Troisi Fabiana , Bilancia Rossella , D'Avino Danilo , Parisi Olga , Rizza Roberta , Stiuso Paola , Gerstmeier Jana , Schädel Patrick , Ialenti Armando , Sautebin Lidia , Serhan Charles N. , Rossi Antonietta , Borrelli Francesca , Werz Oliver 
Published: July 2024

AbstractUnresolved inflammation, due to unfavorable imbalances between pro‐inflammatory and pro‐resolving mediators, leads to chronic inflammatory pathologies that are often sex‐biased and regulated by sex hormones, including inflammatory bowel disease. Lipid mediators (LM) produced from polyunsaturated fatty acids by various lipoxygenases (LOX) and cyclooxygenases govern all stages of inflammation, i.e., the initiation and progression by pro‐inflammatory eicosanoids and its resolution by specialized pro‐resolving mediators (SPM). Here, we reveal sex‐specific differences in murine experimental colitis with male preponderance, which was abolished by sex hormone deprivation using gonadectomy, and this correlated to the levels of inflammation‐relevant mediators in the colon. Oral dextran sodium sulfate administration caused more severe colon inflammation in male CD‐1 mice than in female counterparts during the acute phase. Colitis in males yielded higher colonic cytokine/chemokine levels but lower 12−/15‐LOX‐derived LM including SPM compared to female animals in the resolving phase. Sex hormone deprivation in male mice by orchidectomy ameliorated colitis and impaired pro‐inflammatory cytokine/chemokine levels but elevated 12−/15‐LOX products including SPM, thus abolishing the observed sex differences. Conversely, ovariectomy impaired the levels of those LM that dominated in females and that were increased in males after gonadectomy. Our findings suggest that male sex hormones promote the development of colitis connected to the biosynthesis of inflammatory cytokines, chemokines, and certain LM, especially pro‐resolving 12−/15‐LOX products that appear to be suppressed in the male colon due to androgens.
The potential role of the prolyl isomerase Pin1 during blastocyst implantation and uterine decidualization in mice
Authors: Xu Rui , Li Yunzhi , Li Shupei , Wang Ning , Lin Shuai , Du Tianxi , Wang Fengsong , Zhang Xiuhong 
Published: July 2024

AbstractDuring early pregnancy in mice, the establishment of uterine receptivity and endometrial decidualization require the extensive proliferation and differentiation of endometrial epithelial cells or stromal cells. Pin1 has been suggested to act as a molecular ‘timer’ of the cell cycle and is involved in the regulation of cellular proliferation and differentiation by binding many cell‐cycle regulatory proteins. However, its physiological role during early pregnancy is still not fully understood. Here, we employed immunohistochemistry to determine the spatiotemporal pattern of Pin1 expression during early pregnancy. We found that Pin1 was mainly localized in subluminal stromal cells on day 4, in the decidual zone on days 5 to 8 of pregnancy and in artificial decidualization. Using a uterine stromal cell culture system, we found that progesterone, but not estrogen, induced the expression of Pin1 in a progesterone receptor‐dependent manner. Inhibition of Pin1 in the uterus leads to impaired embryo implantation and decidualization in mice. Notably, a decrease in Pin1 activation affected the functional execution of several implantation‐ or decidualization‐related factors. These findings provide new evidence for a previously unknown function of Pin1 in mediating embryo implantation and decidualization during successful pregnancy establishment and maintenance.
Treatment of Chronic Parastomal Ulceration with Silver Sulfadiazine and Hyaluronic Acid: Two Case Reports
Authors: Carlin Alison 
Published: July 2024

ABSTRACT
Skin complications in individuals with an ostomy are widely reported and can cause physical and emotional challenges in everyday life. Chronic parastomal skin complications can be difficult to heal and cause significant pain.
Two patients presented to the stomal therapy clinic for treatment and were diagnosed with chronic parastomal skin ulceration. Following standard treatment of wound management, topical corticosteroid ointment, and appliance review, the ulcers either were not improving or had reoccurred. Treatment with a combination cream consisting of 0.2% hyaluronic acid and 1% silver sulfadiazine was initiated, and both patients demonstrated complete healing.
Treatment of parastomal skin ulceration with dual-action cream 0.2% hyaluronic acid and 1% silver sulfadiazine was successful for these two patients, with a reduction in pain and purulent fluid noted throughout treatment, in addition to a reduced cost of treatment when compared with standard protocols.
Using Near-Infrared Spectroscopy and Education to Support Older Adults with Diabetic Foot Ulcers to Age-in-Place: A Case Series
Authors: Rickards Tracey , Roberts Christina , Smith Tracey , Shittu Surajudeen , Boodoo Chris , Cross Karen 
Published: July 2024

ABSTRACT
The objective of this article is to demonstrate the added value of foot care provided by an RN with foot care training to older adults in their home by focusing on four older adults with diabetic foot ulcers. The RN used a mobile multispectral near-infrared spectroscopy device to enhance the assessment of the diabetic foot ulcers. The Mobile Seniors Wellness Network methodically engaged with English-speaking adults 55 years and older living within a 90-minute radius of the city’s community health center. Older adults were referred to the research project through various sources. The participation group included 366 participants with varying holistic healthcare concerns and financial stressors that impacted their ability to age well in place. Over the course of visits by the RN and registered social worker, positive outcomes were facilitated through the collaboration of the participant and the multidisciplinary team, thus enhancing the individual's confidence to remain at home longer. In a time of ongoing provincial health crisis, it may be cost-effective to provide in-home support to those who want to age well in their communities by deploying a Mobile Seniors Wellness Network system throughout the province and enhancing the RN’s assessment of feet with a portable and innovative technology tool.
Necrosis and Changes in Pigmentation Following Silver Nitrate Application: A Case Report
Authors: AlAfeefi Mariam , Al Numairy Mohammed , Al Dhamin Ammar 
Published: July 2024

ABSTRACT
Silver nitrate has useful antimicrobial and anti-inflammatory effects. However, there are currently no guidelines in place for its use in cauterization and the management of hemostasis. This lack of guidelines has resulted in different approaches being taken in outpatient and healthcare settings, which can lead to a higher risk of adverse effects. The authors present a case that illustrates a classic but exaggerated adverse effect following silver nitrate application.
Clinical Characteristics and Inciting Agents for Pseudoporphyria: The Mayo Clinic Experience, 1996–2020
Authors: Kumar Anagha Bangalore , Asamoah Eucabeth M. , Wetter David A. , Davis Mark Denis P. , Alavi Afsaneh 
Published: July 2024

ABSTRACT

GENERAL PURPOSE
To raise awareness regarding the clinical presentations of patients with pseudoporphyria.

TARGET AUDIENCE
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES
After participating in this educational activity, the participant will:
1. Describe the clinical presentation of pseudoporphyria.
2. Identify the differential diagnoses of blistering lesions on hands and feet.
3. Outline the management options for patients with porphyria.

BACKGROUND
Pseudoporphyria is an uncommon immunobullous disease that is clinically and histopathologically similar to porphyria cutanea tarda but without abnormal porphyrin levels. Limited case reports and case series of pseudoporphyria have been published.

OBJECTIVE
To describe the clinical characteristics and inciting agents for patients with pseudoporphyria.

METHODS
Health records were retrospectively reviewed for patients treated at an integrated multiregional health system from 1996 through 2020. To report results, the authors used descriptive statistics, median (range) for continuous variables, and number (percentage) for categorical data.

RESULTS
In total, 23 patients met the inclusion criteria: 13 men and 10 women. The most common medications causing pseudoporphyria were nonsteroidal anti-inflammatory drugs, the antihypertensive agent hydrochlorothiazide, and retinoids. All patients had blisters and reported photosensitivity. Seven patients (30.4%) also had scarring, and one (4.3%) had milia. All patients had normal porphyrin levels in their serum, urine, and stool. Among patients with remission, symptoms resolved at a median of 2.5 months (range, 1 week to 24 months) after discontinuation of the suspected inciting medication. Four patients, however, had persistent symptoms at a median of 6 months (range, 2–9 months).

CONCLUSION
Because pseudoporphyria is a diagnosis of exclusion, clinicians should familiarize themselves with the presentation and management of this uncommon condition.
Management of Diabetic Foot Ulcers with Two Forefoot Offloading Techniques: Case Series
Authors: Dunlap Leslie J. , Lew Eric , Gallegos Regina , Murdoch Richard , Mulvihill Simone 
Published: July 2024

ABSTRACT
Offloading is a key principle to healing diabetic foot ulcers. Nonremovable knee-high offloading devices are considered the criterion standard for offloading plantar forefoot ulcers. However, patients exhibit a limited tolerance for these devices, which contributes to a lack of use. In this case series describing two patients, the authors share two alternative offloading modalities for the treatment of diabetic plantar forefoot ulcers. One patient was managed using a football offloading dressing, and the other was managed with a modified felted football dressing. The football and modified felted football offloading dressings provide a cost-effective, less time-consuming application and often are a better-tolerated alternative to nonremovable knee-high offloading devices. Clinical findings support further investigation into dressing options tolerated by patients with improved adherence and optimal healing outcomes.
Establishing a Comprehensive Nursing Clinic Using the Case Management Model
Authors: Teng Li , Xiao Yueping , Chen Daijun , Fu Adan , Zou Guizhen , Luo Tian , Hu Huan , Wang Yun 
Published: July 2024

ABSTRACT

OBJECTIVE
To explore the practical effect of the case management model in a comprehensive nursing clinic.

METHODS
Based on the case management model, the authors constructed a comprehensive nursing clinic providing wound care, ostomy care, peripherally inserted central catheter care, drainage tube care, nursing consultations, and home care. They evaluated the practical effect of the comprehensive nursing clinic according to workload, economic benefits, and satisfaction of the medical staff and patients.

RESULTS
Since the inception of the comprehensive nursing clinic, the number of visits has increased by 63.57%, and the satisfaction of patients and medical staff has also improved.

CONCLUSIONS
This comprehensive nursing clinic based on the case management model meets the medical needs of patients, has improved the satisfaction of patients and the medical staff, and enhances the professional sense of value and comprehensive quality of specialized nurses.
Adherence to Self-care and Quality of Life of Patients with Diabetic Foot Ulcers Treated with Low-Level Laser Therapy: An Exploratory Study
Authors: dos Santos Cristiana Maria , de Souza Lima da Silveira Pedro Renan , da Rocha Rebeca Barbosa , da Silva Sousa Fernanda Mello , Fontenele Alves Rayana , Silva Barros Ana Carolina , Saura Cardoso Vinicius 
Published: July 2024

ABSTRACT

OBJECTIVE
To evaluate the quality of life (QoL) of patients with a diabetic foot ulcer undergoing treatment with low-level laser therapy (LLLT) at 904 nm and its association with self-care.

METHODS
In this randomized, exploratory study, participants were divided into the following four groups: control group (CG) with LLLT placebo, LLLT group 1 (LG1) at 10 J/cm2, LLLT group 2 (LG2) at 8 J/cm2, and LLLT group 3 (LG3) at 4 J/cm2. Participants received light therapy (or placebo) twice a week, for a total of 20 sessions. Researchers assessed participants’ QoL using the Short-Form 36 questionnaire.

RESULTS
Sixty-two participants were included in the analysis (CG = 18, LG1 = 14, LG2 = 17, LG3 = 13). The LG1 group showed a higher proportion of healing, whereas the CG group showed a lower proportion than the other groups. The LG1 group showed a relationship between physical limitations and blood glucose monitoring, pain and foot care, and general health status (GHS) and foot care. The GL2 group showed a relationship between physical limitations and blood glucose monitoring, vitality and foot care, and GHS and diet.

CONCLUSIONS
Low-level laser therapy had a positive impact on QoL as assessed by the Short-Form 36 questionnaire (functional capacity, vitality, and pain domains), and there was a positive association between QoL and self-care in the LLLT groups (physical limitations, pain, GHS, and vitality domains).
No Difference in Short-Term Surgical Outcomes from Semaglutide Treatment for Type 2 Diabetes Mellitus after Cervical Decompression and Fusion
Authors: Tao Xu , Ranganathan Sruthi , Van Halm-Lutterodt Nicholas , Garcia-Vargas Julia , Wu Andrew , Karnati Janesh , Shankar Sachin , Agyeman Nana , Ashraf Ahmed , Barve Parikshit , Childress Kelly , Adogwa Owoicho 
Published: July 2024

Study Design.
Retrospective cohort.

Objective.
To evaluate the impact of semaglutide treatment for Type 2 Diabetes Mellitus (T2DM) on the risk of short-term (<6 months) postoperative complications in patients undergoing primary cervical spine decompression and fusion (CSDF).

Summary of Background Data.
Semaglutide, a GLP-1 receptor agonist, is gaining popularity as a weekly injectable medication for the treatment of T2DM and obesity. Existing research indicates that higher levels of HbA1c and obesity are linked to fewer positive results after undergoing spine surgery, particularly cervical decompression and fusion. Nevertheless, there is a scarcity of publications evaluating the influence of semaglutide therapy on surgical complications, including surgical site infection, wound complications, and reoperation within 6 months, which were aggregated into a composite measure.

Methods.
The PearlDiver Database was queried from January 2010 to December 2021 for patients with a primary diagnosis of T2DM who underwent CSDF for degenerative pathology. Patients with semaglutide treatment within 6 months before index surgery were propensity score-matched to patients without the treatment, employing age, gender, and Charlson comorbidity index (CCI) as matching covariates. A multivariate regression model was used to investigate the impact of semaglutide treatment on postoperative surgical complications.

Results.
The propensity score-matched cohort included 596 patients (semaglutide cohort: 298, control cohort: 298). There were no statistically significant differences between cohorts in the composite measure of postoperative surgical complications following index CSDF (OR 1.26, 95% CI 0.83-1.93, P=0.331). Similarly, both 30-day (OR 0.83, 95% CI 0.49-1.42, P=0.589) and 90-day readmission rate (OR 0.89, 95% CI 0.56-1.42, P=0.724) were similar between both cohorts.

Conclusion.
This study suggests that in patients with T2DM, semaglutide treatment is not associated with higher rates of short-term adverse events after CSDF. The effect of semaglutide use on long-term outcomes remains unknown.
The PROMIS-10 Mental Health T-Score: An Independent Predictor of Recovery for Up to 1 Year After Elective Lumbar Spine Fusion
Authors: Solomito Matthew J. , Kostyun Regina O. , Makanji Heeren 
Published: July 2024

Study Design.
Retrospective comparative cohort.

Objective.
Investigate how mental health, as measured by the PROMIS-10 Global Mental Health T-Score (MHT), influences a patient’s recovery up to 1 year after elective lumbar fusion.

Summary of Background data.
Patients with mental health concerns in need of lumbar fusions have increased. Evidence suggests that mental disorders influence a patient’s postoperative recovery; however, there is a paucity of information detailing the association between mental health and outcomes.

Methods.
A total of 351 patients who underwent 1- or 2-level elective lumbar fusion between April 2020 and June 2023 and completed all follow-up evaluations for up to 1 year postfusion were analyzed for this study. Patients were stratified by their MHT score (above average [AA] >50, average [A] 40-50, below average [BA] <40), regardless of mental illness diagnosis. Outcome measures including pain at hospital discharge and 3, 6, and 12 months after fusion, patient satisfaction, and the Oswestry Disability Index (ODI) score at 3, 6, and 12 months after fusion were compared among groups.

Results.
Nearly 20% of patients reported below-average mental health during their preoperative evaluation. After controlling for confounders, findings suggested that patients in the [BA] group reported 2 pain levels higher than the [AA] group at each time point and 1 point higher than the [A] group. Patients in the [BA] group performed worse on the ODI at all-time points compared with the other study groups. Patients in the [AA] group were 3 times more likely to be satisfied with their outcomes compared with the [BA] group.

Conclusion.
The MHT was an independent predictor of pain, satisfaction, and ODI scores for up to 1 year post-fusion, while a mental disorder diagnosis was not. An MHT score below 40 may be a risk factor for patients undergoing elective lumbar fusion.
Effects of Yoga on Resilience and Coping With Stress in Adolescents
Authors: Canatan Sinem Dağ , Öksüz Emine 
Published: July 2024

This randomized controlled study aimed to determine the effects of yoga on coping with stress in adolescents. The study was conducted in the Famagusta province of Northern Cyprus between September and November 2021. The sample of the study comprised 62 adolescents between the ages of 13 and 16 years, including 30 in the intervention and 32 in the control groups. The descriptive information form, the child and resilience measure (CYRM), and the Kidcope were used for data collection. The intervention group received a 10-week yoga program of 60 minutes twice a week. Pre- and posttest scores were calculated to measure the impact of yoga on resilience and coping with stress. There was a statistically significant difference between the pre- and posttest scores of the yoga intervention group (P < .05). Besides, there was a statistically significant difference between the scores obtained by the intervention and control groups from the CYRM and the subscales of the Kidcope (P < .05). These findings imply that yoga contributes to resilience and coping with stress in adolescents. Based on the findings, we suggest that psychiatric nurses may incorporate yoga to protect the mental health of adolescents.
Stratified health care for low back pain using the STarT Back approach: holy grail or doomed to fail?
Authors: Croft Peter , Hill Jonathan C. , Foster Nadine E. , Dunn Kate M. , van der Windt Danielle A. 
Published: July 2024

Abstract
There have been at least 7 separate randomised controlled trials published between 2011 and 2023 that have examined primary care for nonspecific low back pain informed by the STarT Back approach to stratified care based on risk prediction, compared with care not informed by this approach. The results, across 4 countries, have been contrasting—some demonstrating effectiveness and/or efficiency of this approach, others finding no benefits over comparison interventions. This review considers possible explanations for the differences, particularly whether this is related to poor predictive performance of the STarT Back risk-prediction tool or to variable degrees of success in implementing the whole STarT Back approach (subgrouping and matching treatments to predicted risk of poor outcomes) in different healthcare systems. The review concludes that although there is room for improving and expanding the predictive value of the STarT Back tool, its performance in allocating individuals to their appropriate risk categories cannot alone explain the variation in results of the trials to date. Rather, the learning thus far suggests that challenges in implementing stratified care in clinical practice and in changing professional practice largely explain the contrasting trial results. The review makes recommendations for future research, including greater focus on studying facilitators of implementation of stratified care and developing better treatments for patients with nonspecific low back pain at high risk of poor outcomes.