bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the efficacy of wearable biofeedback on the outcomes of exercise interventions in people with chronic non-specific spinal pain: protocol for a systematic review and meta-analysis
Authors: Deane Janet , Arvanitidis Michail , Briggs Michelle , Falla Deborah , Johnson Mark 
Published: July 2024

IntroductionWearable neuromuscular and biomechanical biofeedback technology has the potential to improve patient outcomes by facilitating exercise interventions. We will conduct a systematic review to examine whether the addition of wearable biofeedback to exercise interventions improves pain, disability and quality of life beyond exercise alone for adults with chronic non-specific spinal pain. Specific effects on clinical, physiological, psychological, exercise adherence and safety outcomes will also be examined.Methods and analysisA systematic search will be conducted from inception to February 2024. Full articles in the English language will be included. MEDLINE, PubMed, CINAHL, EMBASE, Web of Science, PsycINFO, AMED, SPORTDiscus, CENTRAL databases, clinical trial registries and ProQuest (PQDT) will be used to search for eligible studies. Grey literature and conference proceedings (2022–2024) will be searched for relevant reports. Randomised controlled trials using wearable neuromuscular or kinematic biofeedback devices as an adjunct to exercise interventions for the treatment of chronic spinal pain will be included in this systematic review. The comparators will be wearable biofeedback with exercise versus exercise alone, or wearable biofeedback with exercise versus placebo and exercise. Risk of bias will be assessed using Cochrane Back Review Group criteria and the quality of evidence using Grading of Recommendations Assessment, Development and Evaluation recommendations.Ethics and disseminationThe systematic review will be based on published studies, and therefore, does not require ethical approval. The study results will be submitted for publication in an international, open-access, peer-reviewed journal and shared through conferences and public engagement.PROSPERO registration numberCRD42023481393.
Study protocol: Collaboration Oriented Approach to Controlling High blood pressure (COACH) in adults – a randomised controlled trial
Authors: Dorr David Andrew , Montgomery Emma , Ghumman Aisha J , Michaels LeAnn , Rolbiecki Abigail , Canfield Shannon , Shaffer Victoria , Johnson Blake , Lockwood Melinda , Ghosh Parijat , Martinez William , Koopman Richelle 
Published: July 2024

IntroductionHypertension, the clinical condition of persistent high blood pressure (BP), is preventable yet remains a significant contributor to poor cardiovascular outcomes. Digital self-management support tools can increase patient self-care behaviours to improve BP. We created a patient-facing and provider-facing clinical decision support (CDS) application, called the Collaboration Oriented Approach to Controlling High BP (COACH), to integrate home BP data, guideline recommendations and patient-centred goals with primary care workflows. We leverage social cognitive theory principles to support enhanced engagement, shared decision-making and self-management support. This study aims to measure the effectiveness of the COACH intervention and evaluate its adoption as part of BP management.Methods and analysisThe study design is a multisite, two-arm hybrid type III implementation randomised controlled trial set within primary care practices across three health systems. Randomised participants are adults with high BP for whom home BP monitoring is indicated. The intervention arm will receive COACH, a digital web-based intervention with effectively enhanced alerts and displays intended to drive engagement with BP lowering; the control arm will receive COACH without the alerts and a simple display. Outcome measures include BP lowering (primary) and self-efficacy (secondary). Implementation preplanning and postevaluation use the Consolidated Framework for Implementation Research and Reach-Effectiveness-Adoption-Implementation-Maintenance metrics with iterative cycles for qualitative integration into the trial and its quantitative evaluation. The trial analysis includes logistic regression and constrained longitudinal data analysis.Ethics and disseminationThe trial is approved under a single IRB through the University of Missouri-Columbia, #2091483. Dissemination of the intervention specifications and results will be through open-source mechanisms.Trial registration numberNCT06124716.
Stable isotopes of landfast sea ice as a record of La Grande River under-ice plume dispersal
Authors: Diaz Aura , Kuzyk Zou Zou A. , Guzzi Alessia , Gupta Kaushik , Papakyriakou Tim , Ehn Jens K. 
Published: July 2024

Vertical profiles of salinity, and isotopic abundance ratios of hydrogen (δ2H) and oxygen (δ18O) of 18 landfast ice cores, collected along the northeast coast of James Bay in March 2019, and one ice core collected in Belcher Islands, were used to obtain the winter timeseries of the spatiotemporal evolution of the under-ice plume of La Grande River (LGR), the dominant river in the area. Variability in the isotopic composition and salinity of the ice cores indicated changes to the water source composition at the ice–water interface when the ice layers formed. The increased presence of river water beneath the ice during January–March was marked by more negative isotopic ratios in the lower portion of the ice as river discharge was increased for hydroelectric production. River water was the source of ∼43% of the ice in our ice core samples ( n = 320) with the interquartile range from 16% to 71%. The river water fractions incorporated into the ice indicate that LGR under-ice plume extended more than 75 km north and at least 30 km south of the river mouth for ∼3 months. These findings correspond well with more challenging to obtain hydrographic observations. End-of-winter ice core sampling and analysis for isotopic abundance has potential as a tool to monitor dispersal of LGR discharge into the ice-covered coastal environment.
Contribution of coherent electron production to measurements of heavy-flavor decayed electrons in heavy-ion collisions
Authors: Zhang Shenghui , Ma Rongrong , Ji Yuanjing , Tang Zebo , Yang Qian , Zhang Yifei , Zha Wangwei 
Published: July 2024

AbstractHeavy quarks, produced at early stages of heavy-ion collisions, are an excellent probe of the Quark-Gluon Plasma (QGP) also created in these collisions. Electrons from open heavy-flavor hadron decays (HFE) are good proxies for heavy quarks, and have been measured extensively in the last two decades to study QGP properties. These measurements are traditionally carried out by subtracting all known background sources from the inclusive electron sample. More recently, a significant enhancement of $$e^+e^-$$

e
+

e
-

pair production at very low transverse momenta was observed in peripheral heavy-ion collisions. The production characteristics is consistent with coherent photon–photon interactions, which should also constitute a background source to the HFE measurements. In this article, we provide theoretical predictions for the contribution of coherent electron production to HFEs as a function of transverse momentum, centrality and collision energy in Au+Au and Pb+Pb collisions.
Neutron stars in $$f(R,L_m,T)$$ gravity
Authors: Mota Clésio E. , Pretel Juan M. Z. , Flores César O. V. 
Published: July 2024

AbstractThis study explores the behavior of compact stars within the framework of $$f(R,L_m,T)$$

f
(
R
,

L
m

,
T
)

gravity, focusing on the functional form $$f(R,L_m,T) = R + \alpha TL_m$$

f

(
R
,

L
m

,
T
)

=
R
+
α
T

L
m

. The modified Tolman–Oppenheimer–Volkoff (TOV) equations are derived and numerically solved for several values of the free parameter $$\alpha $$
α
by considering both quark and hadronic matter—described by realistic equations of state (EoSs). Furthermore, the stellar structure equations are adapted for two different choices of the matter Lagrangian density (namely, $$L_m= p$$

L
m

=
p

and $$L_m= -\rho $$

L
m

=
-
ρ

), laying the groundwork for our numerical analysis. As expected, we recover the traditional TOV equations in General Relativity (GR) when $$\alpha \rightarrow 0$$

α
→
0

. Remarkably, we found that the two choices for $$L_m$$

L
m

have appreciably different effects on the mass-radius diagrams. Results showcase the impact of $$\alpha $$
α
on compact star properties, while final remarks summarize key findings and discuss implications, including compatibility with observational data from NGC 6397’s neutron star. Overall, this research enhances comprehension of $$f(R,L_m,T)$$

f
(
R
,

L
m

,
T
)

gravity’s effects on compact star internal structures, offering insights for future investigations.
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
Authors: Dilly Julien , Hoffman Megan T. , Abbassi Laleh , Li Ziyue , Paradiso Francesca , Parent Brendan D. , Hennessey Connor J. , Jordan Alexander C. , Morgado Micaela , Dasgupta Shatavisha , Uribe Giselle A. , Yang Annan , Kapner Kevin S. , Hambitzer Felix P. , Qiang Li , Feng Hanrong , Geisberg Jacob , Wang Junning , Evans Kyle E. , Lyu Hengyu , Schalck Aislyn , Feng Ningping , Lopez Anastasia M. , Bristow Christopher A. , Kim Michael P. , Rajapakshe Kimal I. , Bahrambeigi Vahid , Roth Jennifer A. , Garg Kavita , Guerrero Paola A. , Stanger Ben Z. , Cristea Simona , Lowe Scott W. , Baslan Timour , Van Allen Eliezer M. , Mancias Joseph D. , Chan Emily , Anderson Abraham , Katlinskaya Yuliya V. , Shalek Alex K. , Hong David S. , Pant Shubham , Hallin Jill , Anderes Kenna , Olson Peter , Heffernan Timothy P. , Chugh Seema , Christensen James G. , Maitra Anirban , Wolpin Brian M. , Raghavan Srivatsan , Nowak Jonathan A. , Winter Peter S. , Dougan Stephanie K. , Aguirre Andrew J. 
Published: July 2024

Abstract
KRAS inhibitors demonstrate clinical efficacy in pancreatic ductal adenocarcinoma (PDAC); however, resistance is common. Among patients with KRASG12C-mutant PDAC treated with adagrasib or sotorasib, mutations in PIK3CA and KRAS, and amplifications of KRASG12C, MYC, MET, EGFR, and CDK6 emerged at acquired resistance. In PDAC cell lines and organoid models treated with the KRASG12D inhibitor MRTX1133, epithelial-to-mesenchymal transition and PI3K-AKT-mTOR signaling associate with resistance to therapy. MRTX1133 treatment of the KrasLSL-G12D/+; Trp53LSL-R172H/+; p48-Cre (KPC) mouse model yielded deep tumor regressions, but drug resistance ultimately emerged, accompanied by amplifications of Kras, Yap1, Myc, Cdk6, and Abcb1a/b, and co-evolution of drug-resistant transcriptional programs. Moreover, in KPC and PDX models, mesenchymal and basal-like cell states displayed increased response to KRAS inhibition compared to the classical state. Combination treatment with KRASG12D inhibition and chemotherapy significantly improved tumor control in PDAC mouse models. Collectively, these data elucidate co-evolving resistance mechanisms to KRAS inhibition and support multiple combination therapy strategies.
Significance: Acquired resistance may limit the impact of KRAS inhibition in patients with PDAC. Using clinical samples and multiple preclinical models, we define heterogeneous genetic and non-genetic mechanisms of resistance to KRAS inhibition that may guide combination therapy approaches to improve the efficacy and durability of these promising therapies for patients.
See related commentary by Marasco and Misale, p. 2018
Atrioventricular Synchrony Delivered by a Dual-Chamber Leadless Pacemaker System
Authors: Ip James E. , Rashtian Mayer , Exner Derek V. , Reddy Vivek Y. , Doshi Rahul , Badie Nima , Nevo Jordan R. , Goil Aditya , Defaye Pascal , Canby Robert , Bongiorni Maria Grazia , Shoda Morio , Hindricks Gerhard , Knops Reinoud E. 
Published: July 2024

BACKGROUND:
A dual-chamber leadless pacemaker system has been designed for atrioventricular synchronous pacing using wireless, beat-to-beat, implant-to-implant (i2i) communication between distinct atrial and ventricular leadless pacemakers. The atrioventricular synchrony achieved across various ambulatory scenarios has yet to be systematically evaluated.

METHODS:
A prospective, single-arm, unblinded, multicenter, international clinical trial of the leadless pacemaker system was conducted in patients with a conventional dual-chamber pacing indication enrolled from February 2022 to March 2023. Leadless pacemaker systems were implanted, and 12-lead Holter electrocardiographic recordings were collected 3 months after implantation over various postures/activities: sitting, supine, left lateral recumbent, right lateral recumbent, standing, normal walk, and fast walk. An independent Holter core laboratory performed a manual adjudication of the percent of atrioventricular synchronous beats using the standard 300-millisecond PR interval limit. Atrium-to-ventricle and ventricle-to-atrium i2i communication success rates were also assessed. Post hoc summary statistics describing the relationships between atrioventricular synchrony and i2i success, posture/activity, implantation indication, atrioventricular event, and heart rate were calculated.

RESULTS:

In the evaluable population (n=384 of 464 enrolled [83%]; 61% male; age, 70 years; weight, 82 kg; 60% ejection fraction; 95% of beats evaluable), the mean atrioventricular synchrony of 98% of beats observed across all postures using the standard 300-millisecond limit was greater than both atrial-to-ventricular i2i (94%) and ventricular-to-atrial i2i (94%;
P
<0.001), exceeding both i2i values in 95% of patients. Atrioventricular synchrony was achieved in >95% of evaluable beats across all postures/activities, implantation indications, atrioventricular paced/sensed event combinations, and heart rate ranges (including >100 bpm).

CONCLUSIONS:
This dual-chamber leadless pacemaker system demonstrated atrioventricular synchrony in 98% of evaluable beats at 3 months after implantation. Atrioventricular synchrony was maintained across postures/activities and remained robust for heart rates >100 bpm.
Multi-scale structural characterization of ceramic-based photonic glasses for structural colors
Authors: Häntsch Yen , Diaz Ana , Holler Mirko , Krekeler Tobias , Ritter Martin , Rosenfeldt Sabine , Retsch Markus , Furlan Kaline P. 
Published: July 2024

AbstractStructural colors arise from selective light interaction with (nano)structures, which give them advantages over pigmented colors such as resistance to fading and possibility to be fabricated out of traditional low-cost and non-toxic materials. Since the color arises from the photonic (nano)structures, different structural features can impact their photonic response and thus, their color. Therefore, the detailed characterization of their structural features is crucial for further improvement of structural colors. In this work, we present a detailed multi-scale structural characterization of ceramic-based photonic glasses by using a combination of high-resolution ptychographic X-ray computed tomography and small angle X-ray scattering. Our results uncover the structure-processing-properties’ relationships of such nanoparticles-based photonic glasses and point out to the need of a review of the structural features used in simulation models concomitantly with the need for further investigations by experimentalists, where we point out exactly which structural features need to be improved.
Differential gene expression of salt-tolerant alfalfa in response to salinity and inoculation by Ensifer meliloti
Authors: Lundell Seth , Biligetu Bill 
Published: July 2024

Abstract
Background
Alfalfa (Medicago sativa L.) experiences many negative effects under salinity stress, which may be mediated by recurrent selection. Salt-tolerant alfalfa may display unique adaptations in association with rhizobium under salt stress.

Results
To elucidate inoculation effects on salt-tolerant alfalfa under salt stress, this study leveraged a salt-tolerant alfalfa population selected through two cycles of recurrent selection under high salt stress. After experiencing 120-day salt stress, mRNA was extracted from 8 random genotypes either grown in 0 or 8 dS/m salt stress with or without inoculation by Ensifer meliloti. Results showed 320 and 176 differentially expressed genes (DEGs) modulated in response to salinity stress or inoculation x salinity stress, respectively. Notable results in plants under 8 dS/m stress included upregulation of a key gene involved in the Target of Rapamycin (TOR) signaling pathway with a concomitant decrease in expression of the SNrK pathway. Inoculation of salt-stressed plants stimulated increased transcription of a sulfate-uptake gene as well as upregulation of the Lysine-27-trimethyltransferase (EZH2), Histone 3 (H3), and argonaute (AGO, a component of miRISC silencing complexes) genes related to epigenetic and post-transcriptional gene control.

Conclusions
Salt-tolerant alfalfa may benefit from improved activity of TOR and decreased activity of SNrK1 in salt stress, while inoculation by rhizobiumstimulates production of sulfate uptake- and other unique genes.
Genome-wide identification and analysis of monocot-specific chimeric jacalins (MCJ) genes in Maize (Zea mays L.)
Authors: Jiang Hailong , Peng Jiajian , Li Qian , Geng Siqian , Zhang Hualei , Shu Yuting , Wang Rui , Zhang Bin , Li Changsheng , Xiang Xiaoli 
Published: July 2024

Abstract
Background
The monocot chimeric jacalins (MCJ) proteins, which contain a jacalin-related lectin (JRL) domain and a dirigent domain (DIR), are specific to Poaceae. MCJ gene family is reported to play an important role in growth, development and stress response. However, their roles in maize have not been thoroughly investigated.

Results
In this study, eight MCJ genes in the maize genome (designated as ZmMCJs) were identified, which displayed unequal distribution across four chromosomes. Phylogenetic relationships between the ZmMCJs were evident through the identification of highly conserved motifs and gene structures. Analysis of transcriptome data revealed distinct expression patterns among the ZmMCJ genes, leading to their classification into four different modules, which were subsequently validated using RT-qPCR. Protein structures of the same module are found to be relatively similar. Subcellular localization experiments indicated that the ZmMCJs are mainly located on the cell membrane. Additionally, hemagglutination and inhibition experiments show that only part of the ZmMCJs protein has lectin activity, which is mediated by the JRL structure, and belongs to the mannose-binding type. The cis-acting elements in the promoter region of ZmMCJ genes predicted their involvement response to phytohormones, such as abscisic acid and jasmonic acid. This suggests that ZmMCJ genes may play a significant role in both biotic and abiotic stress responses.

Conclusions
Overall, this study adds new insights into our understanding of the gene-protein architecture, evolutionary characteristics, expression profiles, and potential functions of MCJ genes in maize.
Unveiling the mysteries of HvANS: a study on anthocyanin biosynthesis in qingke (hordeum vulgare L. var. Nudum hook. f.) seeds
Authors: Wang Yan , Yao Youhua , Cui Yongmei , An Likun , Li Xin , Bai Yixiong , Ding Baojun , Yao Xiaohua , Wu Kunlun 
Published: July 2024

Abstract
Background
Based on our previous research, a full-length cDNA sequence of HvANS gene was isolated from purple and white Qingke. The open reading frame (ORF) in the purple variety Nierumuzha was 1320 base pairs (bp), encoding 439 amino acids, while the ORF in the white variety Kunlun 10 was 1197 bp, encoding 398 amino acids. A nonsynonymous mutation was found at the position of 1195 bp (T/C) in the coding sequence (CDS) of the HvANS gene. We carried out a series of studies to further clarify the relationship between the HvANS gene and anthocyanin synthesis in Qingke.

Results
The conservative structural domain prediction results showed that the encoded protein belonged to the PLN03178 superfamily. Multiple comparisons showed that this protein had the highest homology with Hordeum vulgare, at 88.61%. The approximately 2000 bp promoter sequence of the HvANS gene was identical in both varieties. The real-time fluorescence PCR (qRT-PCR) results revealed that HvANS expression was either absent or very low in the roots, stems, leaves, and awns of Nierumuzha. In contrast, the HvANS expression was high in the seed coats and seeds of Nierumuzha. Likewise, in Kunlun 10, HvANS expression was either absent or very low, indicating a tissue-specific and variety-specific pattern for HvANS expression. The subcellular localization results indicated that HvANS was in the cell membrane. Metabolomic results indicated that the HvANS gene is closely related to the synthesis of three anthocyanin substances (Idaein chloride, Kinetin 9-riboside, and Cyanidin O-syringic acid). Yeast single hybridization experiments showed that the HvANS promoter interacted with HvANT1, which is the key anthocyanin regulatory protein. In a yeast two-hybrid experiment, we obtained two significantly different proteins (ZWY2020 and POMGNT2-like) and verified the results by qRT-PCR.

Conclusions
These results provide a basis for further studies on the regulatory mechanism of HvANS in the synthesis of anthocyanins in Qingke purple grains.
The ten-year evaluation of clinical characteristics in congenital lung anomaly in pediatrics; a retrospective study in North of Iran
Authors: Lashkarbolouk Narges , Mazandarani Mahdi , Azari Ali Ahani , Ghorbani Somayeh , Shahkar Lobat 
Published: July 2024

Abstract
Introduction
Congenital lung anomalies (CLA) are a group of anomalies, including congenital cystic adenomatoid malformation (CCAM), bronchopulmonary sequestrations (BPS), congenital lobar emphysema (CLE), and bronchogenic cysts (BC). The prevalence of these rare anomalies has risen in recent years, according to various population-based studies due to advances in fetal ultrasound technology.

Method
This retrospective study examines the diagnosis of CLA, and was conducted on 72 patients between March 2014 and March 2024 at Taleghani Pediatric Hospital in Gorgan, Iran.

Result
The average age was 18.8 ± 30.3 months, with the majority being boys (62.5%). Most participants had CCAM (41.7%), followed by CLE (18.1%), BPS (16.7%), pulmonary hypoplasia (9.7%), BC (8.3%), and hybrid lesion (5.6%). The majority of patients were Fars (62.5%), and the average hospitalization days was 9.4 ± 4.5 days. Cardiac anomalies were observed in 19.4% of the patients. 62 patients (86.1%) exhibited respiratory symptoms, and prenatal screening during pregnancy led to the diagnosis in 51 patients (70.8%). Most patients had left lung anomalies (43; 59.7%), and the majority (90.3%) survived. There is a statistically significant relation between needed for surgical treatment and patients’ type of pulmonary lesions (p-value: 0.02). In addition, there was a significant relation between the Fars ethnicity and the presence of cardiac anomalies (p-value: 0.04).

Conclusion
Some CLAs remain undiagnosed or untreated due to the rare nature of congenital lung anomalies. Nevertheless, improvements in ultrasound and other imaging methods will make diagnosing and managing these anomalies during the prenatal period more prevalent, resulting in enhanced understanding.