bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in Pressure under Elastic Bandages: Experimental and Clinical Evaluation
Authors: Sawada Yukimasa 
Published: April 2015

AbstractClinical and experimental studies of pressure under elastic bandages are performed in order to assess their effectiveness in compressing wounds to prevent edema in burn wounds. In experimental studies, pressure decreased slowly over a day when applied with a tension of 250 grams to a limb model without a pad. However, pressure decreased a little more rapidly when applied using a pad, especially when the pad became wet. In clinical studies among patients, the pressure under the elastic bandage decreased more rapidly over time than it did in the experimental studies.From those findings, although harmful side effects such as circulatory disturbances will not occur when an elastic bandage is applied on the limb with a tension of 250 grams, it is very difficult to maintain the initial level of pressure correctly and control the pressure for even the duration of a single day clinically.
Human Papillomavirus Type 6 Associated Buschke‐Loewenstein Tumor (Giant Condyloma Acuminatum)
Authors: Kato Naoko , Ueno Hiroo , Tanaka Hideo , Nishikawa Takeshi 
Published: April 2015

AbstractThe term “Buschke‐Loewenstein tumor” has been used for tumors with exophytic, wart‐like excrescences in the anogenital region. This broadly includes giant condyloma acuminatum and verrucous carcinoma. We report a 44‐year‐old Japanese man with a giant condyloma acuminatum Buschke‐Loewenstein tumor on the right femoinguinal area. The lesion was a huge grape‐like nodule composed of multiple small nodules, reaching 135 × 65 × 40 mm in size.Histologically, it showed a regularly acanthotic papilloma with numerous koilocytes in the upper squamous and granular layers. Ultrastructural findings included gradual differentiation from basal cell layers to uppermost corneocytes without disorganized relationships in the epithelial‐stromal junction or cellular atypia. Human papillomavirus type 6 DNA was detected in the tumor tissues by polymerase chain reaction and restriction enzyme analysis, although immunohistochemical staining for papillomavirus common antigen was negative.
Ringworm‐like Cutaneous Candidiasis: Report of a Case of Localized Type
Authors: Dekio Satoshi , Jidoi Joji 
Published: April 2015

AbstractA 52‐year‐old Japanese female patient with ringworm‐like cutaneous candidiasis on the right axillary area is described. It appeared to have developed in relationship to previous local steroid therapy in this area for a long time.
Autoantibodies in Scleroderma
Authors: Fritzler Marvin J. 
Published: April 2015

AbstractAutoantibodies directed against nuclear, nucleolar, and a number of cytoplasmic components are described in the sera of scleroderma patients. Early studies of autoantibodies that relied on cryopreserved sections of rodent organ substrates showed that approximately 50% of scleroderma patients had anti‐nuclear antibodies (ANA). More recent studies that have used tissue culture cell substrates have shown that up to 98% of scleroderma patients have a positive ANA. In all of these studies, the presence of different patterns of staining have suggested that scleroderma sera reacted with a variety of intracellular antigens. The use of molecular and immunochemical techniques has now shown that over 20 intracellular autoantigens are targets of autoantibodies in scleroderma sera. Clinical studies have shown that these autoantibodies are important diagnostic and prognostic markers in scleroderma. In the future, autoantibody testing may be used to monitor the patient's response to immunological therapies.
A Case of Necrobiosis Lipoidica Treated with Systemic Corticosteroid
Authors: Taniguchi Yoshiki , Sakamoto Takayoshi , Shimizu Masayuki 
Published: April 2015

AbstractA 43‐year‐old woman had asymptomatic eruptions on the anterior sides of both legs for 5 years. Biopsy specimens revealed the typical findings of necrobiosis lipoidica. An immunofluorescence study demonstrated no deposits of immunoglobulins, complement, or fibrinogen in vessel walls. Immunohistochemical staining revealed CD4 positive lymphocytes dominating in the lesion and strong expression of ICAM‐l on the endothelial cells, giant cells, lymphocytes and dermal fibroblasts in the lesion. The eruptions resolved remarkably with oral corticosteroid therapy.
Analyses of Serum Copper and Zinc Levels and Copper/Zinc Ratios in Skin Diseases
Authors: Tasaki Michiko , Hanada Katsumi , Hashimoto Isao 
Published: April 2015

AbstractWith the objective of comprehending abnormal metabolisms of the essential metals of zinc (Zn) and copper (Cu) in three groups of skin diseases, skin cancer, inflammatory diseases, and non‐inflammatory disease, we measured serum levels of Zn and Cu in 151 cases of various cutaneous manifestations and estimated the significance of the ratios between the two metals (Cu/Zn). The serum level of Zn was significantly decreased in cases of bullous pemphigoid, decubitus ulcer, and alopecia areata. The serum level of Cu was elevated in cases of psoriasis, decubitus ulcer, and skin cancer. We observed no elevation of serum Zn level or abnormally depressed serum Cu level. The Cu/Zn ratio showed significantly different values among these three groups of the diseases, suggesting the utility of measuring Cu/Zn ratios for differential diagnosis over that of determining the serum level of Zn or Cu alone. It was also demonstrated that, in each skin disease, the Cu/Zn ratio clearly reflects the severity of the progress.
Electron‐microscopic Observation of a Human Epidermal Langerhans Cell in Mitosis
Authors: Kanitakis Jean , Hoyo Eduardo , Perrin Claude , Schmitt Daniel 
Published: April 2015

AbstractLangerhans cells are dendritic cells of the epidermis originating from bone marrow precursors which may exceptionally undergo mitosis within the skin. We report herein an electron‐microscopic observation of a dividing LC within a seemingly hyperproliferative human epidermis. This observation further underlines the self‐reproducing capacity of LC in situ and suggests that LC may respond to the same mitogenic stimuli as keratinocytes.
A Case of Cutaneous B‐cell Lymphoma Treated Successfully with MACOP‐B
Authors: Nagatani Tetsuo , Miyazawa Megumi , Matsuzaki Toshiko , Hayakawa Hiroki , Iemoto Gaijiro , Kim Shu‐Taku , Baba Naoko , Sugiyama Asami , Aihara Michiko , Miyamoto Hideaki , Nakajima Hiroshi , Katakura Hitoshi 
Published: April 2015

AbstractA case of cutaneous B‐cell lymphoma successfully treated by MACOP‐B therapy is described. The patient was a 43‐year‐old man with reddish tumors measuring 3 to 7 cm in diameter on the right cheek and the post‐auricles. Histopathologically, massive infiltrations of medium‐sized atypical lymphoid cells were found in the reticular dermis and subcutis. A clear zone beneath the epidermis was also detected. The atypical lymphoid cells were positive for CD19, CD20, CD22 and HLA‐DR but negative for CD3, CD4, CD5, CD10, CD43, CD45RO and CDw75. The patient was treated successfully with the MACOP‐B protocol from March of 1990 to May of 1990. Since April of 1990, he has been free of disease.
Dyskeratosis Congenita: A Case Report
Authors: Sehgal Virendra N. , Thappa Devinder M. , Sharma Ravi C. , Jain Sanjiv , Bhattacharya Sambit N. 
Published: April 2015

AbstractDyskeratosis congenita, an uncommon situation in females, is described in a 30‐year‐old woman. The expression of the disease was partial and was characterized by mottled pigmentation, nail dystrophy, palmoplantar keratoderma, and hyperhidrosis.
A Case of Pretibial Dystrophic Epidermolysis Bullosa: Decreased Expression of the Non‐helical Domain of Type VII Collagen Molecule
Authors: Horiguchi Yuji , Leigh Irene M. , Oguchi Motoi , Tanaka Toshihiro , Imamura Sadao 
Published: April 2015

AbstractA 27‐year‐old man with an ataxic gait due to infantile cerebral paralysis exhibited recurrent blistering caused by mechanical stimuli on the pretibial areas of both legs from the age of 20. His parents were not consanguineous, and he had no relatives who suffered from blistering. The histology showed a subepidermal bulla due to dermolytic epidermal‐dermal separation. The anchoring fibrils were sparse and rudimentary in the predilection area. An LH 7:2 monoclonal antibody against the non‐helical domain of the type VII collagen molecule stained the basement membrane zone of the patient's skin at a weaker intensity than the staining of normal human skin, but at a distinctively stronger intensity than the staining of skin from a patient with recessive dystrophic epidermolysis bullosa. Immunoelectron microscopy revealed that LH 7:2‐immuno‐reactants were distributed irregularly within the lamina densa and sparsely in the sublamina densa region. The patient was diagnosed with pretibial dystrophic epidermolysis bullosa.
Secondary Syphilis Mimicking Borderline (BL) Leprosy
Authors: Sehgal Virendra N. , Lal Sardari , Jain Sanjiv , Bhattacharya Sambit N. , Thappa Devender M. , Logani Kulbhusham B. 
Published: April 2015

AbstractA young woman with syphilids resembling borderline lepromatous (BL) leprosy is being described. This is yet another addition to its already well‐documented manifestations. The high prevalence of leprosy and syphilis augments the epidemiological significance of the case.
Introduction of a Fluorescence‐microscopic Technique for the Detection of Eggs, Egg Shells, and Mites in Scabies
Authors: Bhutto Abdul Manan , Honda Minoru , Kubo Yorjiro , Nonaka Shigeo , Yoshida Hikotaro 
Published: April 2015

AbstractA technique using the fluorescence microscope can prove helpful in the laboratory diagnosis of scabies. Specimens from fifteen patients with scabies were used in this study. All of the specimens were embedded with glycerine instead of potassium hydroxide (KOH) solution. The specimens were examined at 0 min, 30 min, 1 hr, 6 hrs, 24 hrs, and one week after mounting under light and fluorescence microscopes. Specimens embedded with non‐fluorescent glycerine were not clear immediately after mounting but became so after about 1 hr. Eggs and egg shells were easily counted in the specimens under the fluorescence microscope but were very hard to identify under the light microscope. Mites were absent in half of the specimens; only eggs and egg shells were present in those specimens found by the fluorescence microscope. The above findings suggest that the detection of egg shells by the use of fluorescence microscope may be helpful for the diagnosis of scabies, in particular with mite negative specimens. Slides prepared with non‐fluorescent glycerine were more stable and could be preserved for a long time. However, this method is time‐consuming and requires expensive equipment.
Reactivity and Persistence of Local Immunological Memory on Murine Contact Hypersensitivity
Authors: Natsuaki Masaru , Yamashita Noriko , Sagami Seiichiro 
Published: April 2015

AbstractIn a rechallenge system examining murine contact hypersensitivity to DNFB in BALB/c mice, the reactivity to the specific antigen at the previously responded site and the persistence of an immunological memory were investigated. Flare‐up reactions were induced 4 weeks after the first challenge only at the previously responded site by local or systemic administrations of minute quantities of a specific antigen. The intensity of ear swelling was dependent on the quantity of applied antigen at the time of the rechallenge. The local hypersensitivity to the specific antigen observed in the previously responded site and the regional lymph node persisted for at least 1 year.These results suggest that the sensitivity to a specific antigen at the previously responded site is intensified and the immunological memory persists for a long time. This may explain the mechanisms by which chronic contact dermatitis recurs readily at the limited site by exposure to minute quantities of causative antigens.
Giant‐cell (Temporal) Arteritis Following a Bypass Operation for Cerebral Infarction
Authors: Tsuji Takuo , Sawabe Motokazu 
Published: April 2015

AbstractA 61‐year‐old man was referred to us with linear and indurated erythemas and severe tenderness on the scalp, neck, tongue, and scrotum which had gradually spread over the previous six months. He had a history of an intracranial bypass operation for cerebral infarction. Histologic and ultrastructural examinations revealed giant‐cell arteries in the skin as well as inflammatory cells infiltrating into nerves. Carotid angiograms indicated stenosis of cranial arteries.It is suggested that the bypass operation may be related to the occurrence of the giant‐cell arteritis and that the inflammatory cell infiltrate into nerves may have caused the severe tenderness of this disease.
Adenoid Cystic Carcinoma of the Skin
Authors: Matsumura Tetsuri , Kumakiri Masanobu , Ohkawara Akira , Yoshida Tetsunori 
Published: April 2015

AbstractAdenoid cystic carcinoma of the skin was studied. Histologically, tumor cells were arranged in a tubular and a cribriform pattern, mainly in the reticular dermis. Immunohistochemically, epithelial membrane antigen was reactive with the tumor cells, but S‐100 protein, vimentin, and carcino‐embryonic antigen were not. On electron microscopy, we confirmed the findings of previous reports; tumor cells were arranged to form luminal structures; most of them were pseudolumina containing fine mucin granules, basal laminae, and collagen fibers, but some were true lumina with numerous microvilli and junctional complexes. New findings of this study were bizarre‐shaped, electron‐dense, net‐like structures within the true lumina which were considered to be a type of mucin.
Childhood Lichen Planus (LP)
Authors: Kumar Vijay , Garg Bhagat R. , Baruah Manik C. , Vasireddi Srinivas S. 
Published: April 2015

AbstractIn adults, lichen planus (LP) is relatively more common than in children. Among 222 cases of LP, there were 25 (11.2%) children in our study. The majority of the cases were females in the age group of 8–14; the youngest child was 3 years old. Papular and linear types of LP were common in children. There was no familial history of LP in any of the cases. The patients with classic LP lesions responded well to dapsone therapy. This study supports the suggestion of Ramsay and Hurley that childhood LP is more common in the tropics.
The Incidence of Isolation of Methicillin‐resistant Staphylococcus aureus (MRSA) Strains from Skin Infections during the Past Three Years (1989–1991)
Authors: Nishijima Setsuko , Namura Shoko , Mitsuya Kaoru , Asada Yasuo 
Published: April 2015

AbstractWe did a statistical study of 294 strains of Staphylococcus aureus (S. aureus) isolated from skin infections during the period from January of 1989 to December of 1991 in the Department of Dermatology, Kansai Medical University Hospital. We especially examined methicillin‐resistant S. aureus (MRSA) from the point of view of incidence, variety of skin infections with MRSA, coagulase type, phase type, and resistance against antimicrobial agents. The frequency of isolation of MRSA has been increasing. In 1991, the proportion of MRSA isolates among all S. aureus strains isolated from skin infections was 41.5%. MRSA was isolated most often from infectious decubitus. Coagulase type II and phage group NT (not typable) MRSA were most frequently isolated. The resistance of MRSA to OFLX and IMP/CS had remarkably increased. Notably, the resistance to MINO was low before 1991.
Nuclear DNA Content and Distribution of Ki‐67 Positive Cells in Nodular Fasciitis
Authors: Ooe Mariko , Ishiguro Naoko , Kawashima Makoto 
Published: April 2015

AbstractNodular fasciitis (NF) is regarded as a disease of reactive growth of fibroblasts, although it frequently shows clinically rapid growth and sometimes has to be histologically discriminated from fibrosarcoma. In order to confirm the position of NF as a benign tumor, we studied 5 cases of NF by a quantitative analysis of the nuclear DNA content using flow cytometry in paraffin‐embedded specimens. In 3 of the 5 cases, an immunohistochemical study using Ki‐67 monoclonal antibody was also conducted in frozen sections. In the analysis of nuclear DNA content, DNA histograms showed a diploid pattern in all cases, and G1, S and G2 + M periods were calculated as 96.7%, 2.5% and 0.8% (on the average), respectively. Although the labeling index of Ki‐67 antibody (positive cells/tumor cells; %) was as scattered as 1.3–7.8 (5.6 on the average), the mean value was higher than that in already reported dermatofibroma and dermatofibrosarcoma protuberans and lower than that in malignant fibrous histiocytoma. These results endorse the hypothesis that NF is a reactive benign disease and reflect the biological behavior of this disease, which may frequently show rapid growth.
Generalized Skin Reaction Following Tinea Pedis (Dermatophytids)
Authors: Iglesias M. Eugemia , España Agustin , Idoate Miguel A. , Quintanilla Emilio 
Published: April 2015

AbstractAn 11‐year‐old boy presented with inflamed tinea pedis followed by a generalized id type skin eruption, with disappearance of the rash after treatment of the mycotic foot lesions. The pathogenesis of this process is not precisely known. Fungal infection was not detected from the generalized skin lesions. Various clinical forms of dermatophytid reaction are discussed.
Immunohistochemical Study of Elevated Expression of Squamous Cell Carcinoma (SCC)‐Related Antigens in Erythrodermic Epidermis
Authors: Horiuchi Yasuhiro , Tsukahara Tetsuya , Otoyama Kazunobu 
Published: April 2015

AbstractUsing immunohistochemical staining with the monoclonal antibodies (mAb) of squamous cell carcinoma‐related antigens (SCC‐RAg), the expression of SCC‐RAg in erythrodermic epidermis, which included senile erythroderma following eczema, atopic erythroderma, psoriatic erythroderma, and Sézary syndrome was examined. In senile erythroderma and atopic dermatitis, the most intense staining with SCC‐RAg mAb was evident in the upper epidermis. The cytoplasm of epidermal cells showed particularly strong staining. Although serum SCC‐RAg in the Sézary syndrome was not as high as in other erythroderma patients, staining with SCC‐RAg mAb was relatively strong in the upper epidermis. However, in psoriatic erythroderma cases with severe skin conditions, staining was weakly positive and diffuse throughout the entire epidermis. Following treatment, SCC‐RAg decreased significantly with remission. Elevated SCC‐RAg release may be attributed to epidermal cells, and SCC‐RAg should prove useful as a clinical marker of erythroderma.
Acute Urticaria: History and Natural Course of 50 Cases
Authors: Aoki Toshiyuki , Kojima Masuko , Horiko Tamio 
Published: April 2015

AbstractFifty patients with acute urticaria who visited within a week after the onset were interviewed and the history around the onset of urticaria was carefully taken. It was known that the majority of the patients had experienced some symptoms suggestive of infection. The patients were followed up for a year to determine the last efflorescence. It was disclosed that 43 cases were cured within two weeks and 5 other cases were cured between 2 weeks and 3 months. The remaining 2 cases persisted over a year.These results seem to suggest that urticaria is an immunologically erroneous reaction to foreign body innoculation, a large majority of which is acute infection.
A Statistical Study on In vivo Sorption and Desorption of Water in Ichthyosis Vulgaris
Authors: Mukherjee Soma , Gupta Amulya Bhusan 
Published: April 2015

AbstractExperiments on the variation of electrical conductance on sorption and desorption of water were performed on the skin of 34 subjects: 17 ichthyosis vulgaris patients and 17 normal subjects, matched for age and gender, under different ambient conditions. An exponential model of the form ft=θoeθt, where ft denotes fractional conductance at time t, describes the process of desorption with high accuracy. The parameter θ, identifiable as the rate of desorption, is significantly different between the ichthyotic and normal populations. The study discusses the impaired barrier function of the ichthyotic skin.
Histopathological Features of Recalcitrant Erythema of the Face in Adult Patients with Atopic Dermatitis
Authors: Omoto Mitsuyoshi , Sugiura Hisashi , Uehara Masami 
Published: April 2015

AbstractRecalcitrant erythema on the face of 21 adult patients with atopic dermatitis was histologically examined. All patients had been applying topical corticosteroids to the facial erythema for three years or more.The histopathology of the recalcitrant facial erythema was not homogeneous. Thus, the facial erythema was roughly classified into three categories: 1) erythema which mainly showed eczematous changes, 2) erythema which mainly showed steroid‐induced rosacea‐like changes, and 3) erythema which showed both eczematous changes and steroid‐induced rosacea‐like changes. The majority (75%) of recalcitrant facial erythema belonged to the third category.
Psoriasis Verrucosa Showing Peculiar Histologic Features
Authors: Nakamura Sawako , Mihara Motoyuki , Hagari Yoshitaka , Shimao Shuhei 
Published: April 2015

AbstractA 60‐year‐old man had a 10‐year history of linearly arranged verrucous papules on his left fingers in addition to psoriatic erythematosquamous papules and plaques on his trunk and extremities. The verrucous papules were clinically classified into two types: dome‐shaped papules with a keratotic plug and crater‐shaped papules with a central depression. Histopathologically, the former showed cup‐shaped acanthosis with a parakeratotic column containing Munro's microabscesses, while the latter showed a cup‐shaped epidermal invagination with Kogoj's spongiform pustule‐like changes. Both types of papules were clinically diagnosed as psoriasis verrucosa, but their histologic features differed from those reported previously.
An Unusual Form of Skin Tuberculosis Following B.C.G. Vaccination
Authors: Lee Seung Min , Hann Seung Kyung , Chun Soo II , Lee Seung Hung , Park Yoon‐Kee 
Published: April 2015

AbstractA 25‐year‐old female has had brown to erythematous telangiectatic patches and grouped papules on her face, neck, arm, and trunk since childhood following B.C.G. vaccination. Histopathologically, the lesions consisted of hyperkeratosis, slight acanthosis, tuberculoid granulomas with some Langerhans type giant cells in the mid‐dermis.Although various forms of cutaneous tuberculosis after B.C.G. vaccination have been reported, it was difficult for us to assign the patient's skin lesion to any specific disease entity. Remission of her cutaneous lesions occurred clinically and histopathologically after treatment with isoniazid and rifampin.
Skin Diseases First Described in Japan
Authors: Teraki Yuichi , Nishikawa Takeji 
Published: April 2015

AbstractOver the 90 year history of dermatology in Japan, about 30 skin diseases have been first described by our colleagues. Although some of them have become well known internationally, many of them are less well known outside of Japan. In this article, we introduce those conditions first described in Japan which are lesser known but have international significance.