bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy
Authors: Lin Alexander P , Ramadan Saadallah , Stern Robert A , Box Hayden C , Nowinski Christopher J , Ross Brian D , Mountford Carolyn E 
Published: February 2015

Abstract
Introduction
The goal was to identify which neurochemicals differ in professional athletes with repetitive brain trauma (RBT) when compared to healthy controls using a relatively new technology, in vivo Localized COrrelated SpectroscopY (L-COSY).

Methods
To achieve this, L-COSY was used to examine five former professional male athletes with 11 to 28 years of exposure to contact sports. Each athlete who had had multiple symptomatic concussions and repetitive sub concussive trauma during their career was assessed by an experienced neuropsychologist. All athletes had clinical symptoms including headaches, memory loss, confusion, impaired judgment, impulse control problems, aggression, and depression. Five healthy men, age and weight matched to the athlete cohort and with no history of brain trauma, were recruited as controls. Data were collected from the posterior cingulate gyrus using a 3 T clinical magnetic resonance scanner equipped with a 32 channel head coil.

Results
The variation of the method was calculated by repeated examination of a healthy control and phantom and found to be 10% and 5%, respectively, or less. The L-COSY measured large and statistically significant differences (P ≤0.05), between healthy controls and those athletes with RBT. Men with RBT showed higher levels of glutamine/glutamate (31%), choline (65%), fucosylated molecules (60%) and phenylalanine (46%). The results were evaluated and the sample size of five found to achieve a significance level P = 0.05 and a power of 90%. Differences in N-acetyl aspartate and myo-inositol between RBT and controls were small and were not statistically significance.

Conclusions
A study of a small cohort of professional athletes, with a history of RBT and symptoms of chronic traumatic encephalopathy when compared with healthy controls using 2D L-COSY, showed elevations in brain glutamate/glutamine and choline as recorded previously for early traumatic brain injury. For the first time increases in phenylalanine and fucose are recorded in the brains of athletes with RBT. Larger studies utilizing the L-COSY method may offer an in-life method of diagnosis and personalized approach for monitoring the acute effects of mild traumatic brain injury and the chronic effects of RBT.
A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid
Authors: Yang Ting , O’Malley Tiernan T , Kanmert Daniel , Jerecic Jasna , Zieske Lynn R , Zetterberg Henrik , Hyman Bradley T , Walsh Dominic M , Selkoe Dennis J 
Published: February 2015

Abstract
Introduction
Amyloid β-protein oligomers play a key role in Alzheimer’s disease (AD), but well-validated assays that routinely detect them in cerebrospinal fluid (CSF) are just emerging. We sought to confirm and extend a recent study using the Singulex Erenna platform that reported increased mean CSF oligomer levels in AD.

Methods
We tested four antibody pairs and chose one pair that was particularly sensitive, using 1C22, our new oligomer-selective monoclonal antibody, for capture. We applied this new assay to extracts of human brain and CSF.

Results
A combination of 1C22 for capture and 3D6 for detection yielded an Erenna immunoassay with a lower limit of quantification of approximately 0.15 pg/ml that was highly selective for oligomers over monomers and detected a wide size-range of oligomers. Most CSFs we tested had detectable oligomer levels but with a large overlap between AD and controls and a trend for higher mean levels in mild cognitive impairment (MCI) than controls.

Conclusion
Aβ oligomers are detectable in most human CSFs, but AD and controls overlap. MCI CSFs may have a modest elevation in mean value by this assay.
Outage performance of relay-assisted transmissions in cognitive full-duplex relay networks
Authors: Chen Hongbin , Tan Songgao , Zhao Feng 
Published: January 2015

Abstract
Relay cooperation can enhance coverage, throughput, and reliability of wireless communication systems, thus attracting intense research interest in the past decade. However, most of them focused on half-duplex relay systems, which encounter loss of resource efficiency. With the progress of self-interference cancellation technologies, full-duplex relay systems come into sight. In this paper, outage performances of the primary system and the secondary system in a cognitive full-duplex relay network are analyzed, under the adverse effect of self-interference caused by the signals at the transmitting and receiving antennas of the relay. The full-duplex decode-and-forward relay assists the transmissions of the primary system and the secondary system where there is no direct link between the secondary transmitter and the secondary receiver. Simulation results show that better outage performance of the primary system is achieved compared with the cognitive relay network adopting half-duplex relaying. Moreover, communication of the secondary system is realized on the condition that the secondary transmission link is non-ideal.
Self-optimized heterogeneous networks for energy efficiency
Authors: Fan Shaoshuai , Tian Hui , Sengul Cigdem 
Published: February 2015

AbstractExplosive increase in mobile data traffic driven by the demand for higher data rates and ever-increasing number of wireless users results in a significant increase in power consumption and operating cost of communication networks. Heterogeneous networks (HetNets) provide a variety of coverage and capacity options through the use of cells of different sizes. In these networks, an active/sleep scheduling strategy for base stations (BSs) becomes an effective way to match capacity to demand and also improve energy efficiency. At the same time, environmental awareness and self-organizing features are expected to play important roles in improving the network performance. In this paper, we propose a new active/sleep scheduling scheme based on the user activity sensing of small cell BSs. To this end, coverage probability, network capacity, and energy consumption of the proposed scheme inK-tier heterogeneous networks are analyzed using stochastic geometry, accounting for cell association uncertainties due to random positioning of users and BSs, channel conditions, and interference. Based on the analysis, we propose a sensing probability optimization (SPO) approach based on reinforcement learning to acquire the experience of optimizing the user activity sensing probability of each small cell tier. Simulation results show that SPO adapts well to user activity fluctuations and improves energy efficiency while maintaining network capacity and coverage probability guarantees.
Some results on an infinite family of accretive operators in a reflexive Banach space
Authors: Wang Sheng-Hua , Zhang Po 
Published: January 2015

AbstractThe purpose of this article is to investigate a Halpern-like proximal point algorithm for common zero points of an infinite family of accretive operators. Possible computational errors are taken into account. Strong convergence theorems are established in a reflexive Banach space.
Viscosity approximation method with Meir-Keeler contractions for common zero of accretive operators in Banach spaces
Authors: Kim Jong Kyu , Tuyen Truong Minh 
Published: January 2015

AbstractThe purpose of this paper is to introduce a new iteration by the combination of the viscosity approximation with Meir-Keeler contractions and proximal point algorithm for finding common zeros of a finite family of accretive operators in a Banach space with a uniformly Gâteaux differentiable norm. The results of this paper improve and extend corresponding well-known results by many others.
Strong and △-convergence theorems for two asymptotically nonexpansive mappings in the intermediate sense in $\operatorname{CAT}(0)$ spaces
Authors: Saluja Gurucharan S , Postolache Mihai 
Published: January 2015

AbstractIn this paper, we study strong and △-convergence for a newly defined two-step iteration process involving two asymptotically nonexpansive mappings in the intermediate sense which is wider than the class of asymptotically nonexpansive mappings in the setting of $\operatorname{CAT}(0)$
CAT
(
0
)
spaces. Our results generalize, unify and extend many known results from the existing literature.
Weak convergence theorems for inverse-strongly skew-monotone operators and generalized mixed equilibrium problems in Banach spaces
Authors: Chen Junmin , Fan Tiegang 
Published: January 2015

AbstractIn this paper, we consider an iterative algorithm for finding the common element of the set of solutions for the generalized mixed equilibrium problems, the common fixed points set of two generalized nonexpansive type mappings, and the set of solutions of the variational inequality for an inverse-strongly skew-monotone operator in Banach spaces. Under mild conditions, the weak convergence theorem is established by using the sunny generalized nonexpansive retraction in Banach spaces. Our results refine, supplement, and extend the corresponding results in (Saewan et al. in Optim. Lett. 8:501-518, 2014), and other results announced by many other authors.
A hybrid iterative method for common solutions of variational inequality problems and fixed point problems for single-valued and multi-valued mappings with applications
Authors: Onjai-uea Nawitcha , Phuengrattana Withun 
Published: January 2015

AbstractIn this article, we propose a new iterative method for approximating a common element of the set of common fixed points of a finite family of k-strictly pseudononspreading single-valued mappings, the set of common fixed points of a finite family of quasi-nonexpansive multi-valued mappings, and the set of common solutions of a finite family of variational inequality problems in Hilbert spaces. Furthermore, we prove that the proposed iterative method converges strongly to a common element of the above three sets, and we also apply our results to complementarity problems. Finally, we give two numerical examples to support our main result.
Variations in level of oil, protein, and some antioxidants in chickpea and peanut seeds
Authors: Dragičević Vesna , Kratovalieva Suzana , Dumanović Zoran , Dimov Zoran , Kravić Natalija 
Published: January 2015

Abstract

Background
Chickpea and peanut are two legume species not frequently used in human diets. Chickpea is rich in starch and proteins, while peanut is mainly a source of oils and proteins and they could be successfully used as protein sources in vegetarian diets.
Seeds of 19 chickpea and 13 peanut landraces were colorimetrically analyzed in respect to antioxidant content (i.e., free soluble phenolics, total glutathione, and phytate). Oil and protein contents in grain were also determined.

Results
Free soluble phenolics content varied in range from 520 to1,050 mg kg−1 in peanut and from 720 to 1,370 mg kg−1 in chickpea. Total glutathione content ranged from 1,495 to 2,365 mmol kg−1 in peanut and from 955 to 1,232 mmol kg−1 in chickpea. Relatively low content of phytic phosphorus was found in grain of both species, ranging from 2.5 to 4.5 g kg−1 in peanut and from 1.4 to 3.0 g kg−1 in chickpea, respectively. Considering the lack of data for phytate variability in Macedonian chickpea and peanut local landraces up to date, the observed high variation in phytic phosphorus content could represent the great basis for further breeding programs for phytate decrease in seeds of those genotypes. This is significant, since phytate is an important antinutrient which affects availability of mineral elements. Regression analysis revealed positive and highly significant interdependence between oil content and total glutathione in chickpea seeds, as well as between oil content and phytic phosphorus in peanut seeds. In chickpea, significant and negative correlation between oil and phytic phosphorus content was also observed.

Conclusions
Results obtained indicated that chickpea genotypes with higher oil content could have increased nutritional value due to higher glutathione and lower phytate content observed. However, lower level of phytate content, along with higher level of soluble phenolics and total glutathione found in peanut seeds with lower oil content, indicated higher digestibility and increased antioxidant activity of those genotypes.
Symbolic meanings of women’s dress on Korean film <Madame Freedom> from the fifties
Authors: Yoon Jinyoung , Yim Eunhyuk 
Published: February 2015

AbstractThe mid-20th century, covering the end of the colonial rule and the Korean War, represented for Korea a period of tumultuous changes in the people’s way of life as well as their value system. Women grew more active in professional and social capacities, and began to claim a status equal to that of men as their economic role within the family expanded. The just claim for a foray beyond the family boundaries, coming from women married to upper-middle-class husbands and consequently enjoying an opulent lifestyle, becomes a major theme of the film <Madame Freedom>.In it, we find a variety of female roles, ranging from not just the then oft-discussed ‘liberated wives’, but also to college students, single professionals, housewives with husbands in positions of prestige, and businesswomen. These characters’ appearance, including their dress, makeup and body awareness, also function as symbols expressing the message and social role each character represents. The study examines the 1956 film <Madame Freedom> to explore how the conflict between the social environment surrounding the female characters, conventional values and self - image manifest themselves in their dress and the changes thereof in both family and broader social life, and to determine what symbolic significance such manifestations have.
Meaning-Centered Group Psychotherapy: An Effective Intervention for Improving Psychological Well-Being in Patients With Advanced Cancer
Authors: Breitbart William , Rosenfeld Barry , Pessin Hayley , Applebaum Allison , Kulikowski Julia , Lichtenthal Wendy G. 
Published: February 2015

Purpose To test the efficacy of meaning-centered group psychotherapy (MCGP) to reduce psychological distress and improve spiritual well-being in patients with advanced or terminal cancer. Patients and Methods Patients with advanced cancer (N = 253) were randomly assigned to manualized eight-session interventions of either MCGP or supportive group psychotherapy (SGP). Patients were assessed before and after completing the treatment and 2 months after treatment. The primary outcome measures were spiritual well-being and overall quality of life, with secondary outcome measures assessing depression, hopelessness, desire for hastened death, anxiety, and physical symptom distress. Results Hierarchical linear models that included a priori covariates and only participants who attended ≥ three sessions indicated a significant group × time interaction for most outcome variables. Specifically, patients receiving MCGP showed significantly greater improvement in spiritual well-being and quality of life and significantly greater reductions in depression, hopelessness, desire for hastened death, and physical symptom distress compared with those receiving SGP. No group differences were observed for changes in anxiety. Analyses that included all patients, regardless of whether they attended any treatment sessions (ie, intent-to-treat analyses), and no covariates still showed significant treatment effects (ie, greater benefit for patients receiving MCGP v SGP) for quality of life, depression, and hopelessness but not for other outcome variables. Conclusion This large randomized controlled study provides strong support for the efficacy of MCGP as a treatment for psychological and existential or spiritual distress in patients with advanced cancer.
Current Evidence and Future Perspectives on the Effective Practice of Patient-Centered Laboratory Medicine
Authors: Hallworth Mike J , Epner Paul L , Ebert Christoph , Fantz Corinne R , Faye Sherry A , Higgins Trefor N , Kilpatrick Eric S , Li Wenzhe , Rana S V , Vanstapel Florent 
Published: February 2015

AbstractBACKGROUNDSystematic evidence of the contribution made by laboratory medicine to patient outcomes and the overall process of healthcare is difficult to find. An understanding of the value of laboratory medicine, how it can be determined, and the various factors that influence it is vital to ensuring that the service is provided and used optimally.CONTENTThis review summarizes existing evidence supporting the impact of laboratory medicine in healthcare and indicates the gaps in our understanding. It also identifies deficiencies in current utilization, suggests potential solutions, and offers a vision of a future in which laboratory medicine is used optimally to support patient care.SUMMARYTo maximize the value of laboratory medicine, work is required in 5 areas: (a) improved utilization of existing and new tests; (b) definition of new roles for laboratory professionals that are focused on optimizing patient outcomes by adding value at all points of the diagnostic brain-to-brain cycle; (c) development of standardized protocols for prospective patient-centered studies of biomarker clinical effectiveness or extraanalytical process effectiveness; (d) benchmarking of existing and new tests in specified situations with commonly accepted measures of effectiveness; (e) agreed definition and validation of effectiveness measures and use of checklists for articles submitted for publication. Progress in these areas is essential if we are to demonstrate and enhance the value of laboratory medicine and prevent valuable information being lost in meaningless data. This requires effective collaboration with clinicians, and a determination to accept patient outcome and patient experience as the primary measure of laboratory effectiveness.
From suits to robes: The use of African inspired apparel as a communication tool in the mid-twentieth-century American avant-garde jazz community
Authors: Cottle C. Adam , Cottle Frederick S. , Bell Thomas W. 
Published: February 2015

Abstract
Many musicians working in the avant-garde of American jazz in the post-Civil Rights era publicly aligned themselves with black power cultural ideologies. The Afrocentric fashions worn by some of these musicians were a visual representation of their cultural beliefs and endure as a major component of the musical form’s legacy. This article reevaluates these performers’ standing in popular culture, recognizing them as fashion innovators on top of being musical revolutionaries. These musicians’ adventurous style lives on in popular culture through fashion statements in hip hop, neo soul and other musical genres.
All black everything: Gothic cloak and swagger in contemporary hip hop
Authors: Sollee Kristen 
Published: February 2015

Abstract
In stark contrast to the widespread popularity of the Gothic literary genre in the eighteenth and nineteenth centuries, goth music and goth fashion were largely relegated to subculture from their inception in the late 1970s. Over the past decade, however, goth fashion has moved past its musical counterpart into ubiquity, stretching its shadow-laced fingers across popular culture and into contemporary hip hop as artists incorporate goth aesthetics and Gothic literary themes into their expanding style lexicons. From the ‘Ghetto Gothic’ fashions of A$AP Rocky and Mykki Blanco to the monochromatic macabre videos of Jay-Z and Kanye West, the sartorial signs of the doomed undead are now de rigueur in rap, and washes of reverb-laden guitar beneath mournful Anglo-European voices are no longer prerequisites for sepulchral style. Contrary to the authenticity-obsessed goth scene, this phenomenon can be viewed as momentary ‘Gothic drag’, or more in keeping with hip hop culture, as ‘aesthetic sampling’ that mirrors the long-standing tradition of music sampling in rap. Rather than standing in opposition to classic definitions of goth subculture or Gothic literary tropes, the cultural syncretism in today’s hip hop serves to revitalize and recontextualize the entire macabre genre, rendering it more inclusive of diversity and free from its characteristic restraints.
Space exploration by dendritic cells requires maintenance of myosin II activity by IP3 receptor 1
Authors: Solanes Paola , Heuzé Mélina L , Maurin Mathieu , Bretou Marine , Lautenschlaeger Franziska , Maiuri Paolo , Terriac Emmanuel , Thoulouze Maria‐Isabel , Launay Pierre , Piel Matthieu , Vargas Pablo , Lennon‐Duménil Ana‐Maria 
Published: January 2015

AbstractDendritic cells (DCs) patrol the interstitial space of peripheral tissues. The mechanisms that regulate their migration in such constrained environment remain unknown. We here investigated the role of calcium in immature DCs migrating in confinement. We found that they displayed calcium oscillations that were independent of extracellular calcium and more frequently observed in DCs undergoing strong speed fluctuations. In these cells, calcium spikes were associated with fast motility phases. IP3 receptors (IP3Rs) channels, which allow calcium release from the endoplasmic reticulum, were identified as required for immature DCs to migrate at fast speed. The IP3R1 isoform was further shown to specifically regulate the locomotion persistence of immature DCs, that is, their capacity to maintain directional migration. This function of IP3R1 results from its ability to control the phosphorylation levels of myosin II regulatory light chain (MLC) and the back/front polarization of the motor protein. We propose that by upholding myosin II activity, constitutive calcium release from the ER through IP3R1 maintains DC polarity during migration in confinement, facilitating the exploration of their environment.
Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure
Authors: Ising Christina , Koehler Sybille , Brähler Sebastian , Merkwirth Carsten , Höhne Martin , Baris Olivier R , Hagmann Henning , Kann Martin , Fabretti Francesca , Dafinger Claudia , Bloch Wilhelm , Schermer Bernhard , Linkermann Andreas , Brüning Jens C , Kurschat Christine E , Müller Roman‐Ulrich , Wiesner Rudolf J , Langer Thomas , Benzing Thomas , Brinkkoetter Paul Thomas 
Published: February 2015

AbstractMitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin‐2 (PHB2) at the mitochondrial inner membrane. Here, we provide a link between PHB2 deficiency and hyperactive insulin/IGF‐1 signaling. Deletion of PHB2 in podocytes of mice, terminally differentiated cells at the kidney filtration barrier, caused progressive proteinuria, kidney failure, and death of the animals and resulted in hyperphosphorylation of S6 ribosomal protein (S6RP), a known mediator of the mTOR signaling pathway. Inhibition of the insulin/IGF‐1 signaling system through genetic deletion of the insulin receptor alone or in combination with the IGF‐1 receptor or treatment with rapamycin prevented hyperphosphorylation of S6RP without affecting the mitochondrial structural defect, alleviated renal disease, and delayed the onset of kidney failure in PHB2‐deficient animals. Evidently, perturbation of insulin/IGF‐1 receptor signaling contributes to tissue damage in mitochondrial disease, which may allow therapeutic intervention against a wide spectrum of diseases.