bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESIGNING FOR DEMENTIA AND PALLIATIVE CARE: A REVIEW
Authors: O'Brien D 
Published: April 2013

BackgroundWith a global shift towards the concept ofAging in Place,aged care facilities will increasingly be occupied by the physically frail, those suffering from late stage dementia and those seeking palliative care outside of the home. We ask what role the built environment will play in this context and how useful are current Australian design guidelines?AimsReview current Australian design guidelines.Review global research literature and design precedents.Develop a strategy for integration of ongoing research into the design process.MethodsWe assessed available design guidelines in Victoria, NSW and South Australia against 312 peer reviewed papers from the fields of sociology, gerontology and neurophysiology and architecture.ResultsA growing body of evidence supports the hypothesis that the design of aged care environments has a direct impact on the experience and treatment of dementia patients and also on the well-being of staff. Australian design guidelines however are aspirational, problem-focussed and lack detailed reference to this evidence-base.DiscussionAvailable evidence can radically improve current design guidelines; however it must be recognised that the data has primarily come from non-randomised, short-term research projects.ConclusionCo-ordinated, longitudinal and randomised research is required to continuously improve the evidence base. We contend that this paradigm shift can only occur if stimulated by aged care providers and integrated into architectural practice.
QUALITY OF END-OF-LIFE CARE
Authors: Hussin E , Omar E , Subramanian P , Wong L P 
Published: April 2013

BackgroundCritical care units (ICU) have been designed to provide highly skilled, lifesaving care for patients with acute illnesses or injuries. The mortality rate in the ICU still remains as a high rate comparing to the general word (Steinhauseret al., 2002). Having a good quality of end of life care (EOLC) is a common wish for patients who dying in the ICU. Quality of EOLC is the most popular measure to evaluate the quality of care provided to critically ill patients in the critical care units.AimThis paper aimed to systematically review original studies of quality of EOLC and appraise their quality.MethodOnly the original Studies that concerned on the quality of EOLC were included. Words like quality of EOLC, quality of dying and death were used to search in Midline and Ovid online data bases.ResultForty-nine studies met the selection criteria. These 31 quantitative, 16 qualitative and 2 mixed method studies identified different level of satisfaction to the quality of EOLC.DiscussionThe quality of EOLC still need to improve and barriers such as communication, lack of education and experiences, pain management, high expectations of families and environmental circumstances stile hindered the quality of EOLC.Conclusiondifferent studies were conducted using different measures and methods to understand the quality of EOLC; however, further studies to identify the best strategies to improve EOLC are needed.
QUALITY OF END OF LIFE FOR LONG- TERM VENTILATED ADULTS WITH TRACHEOSTOMY AND THEIR FAMILIES- A PRACTICAL SOLUTION AND PRACTICAL INTRODUCTION
Authors: Hutzel P 
Published: April 2013

BackgroundBased on clinical experience in Intensive Care, as well as experience in the Intensive Home Care setting in Germany, a number of long-term ventilated Adults with Tracheostomy can be provided with Quality of end of Life at Home rather than in ICU.AimThe provision of Intensive Home Care Nursing services for Patients and Families who wish to die at Home, with a holistic focus on Patients and Families needs. Furthermore, Intensive Home Care is a cost effective model compared to the provision of Hospital ICU servicesMethodsThe provision of Intensive Home Care Nursing services for long-term ventilated Patients with Tracheostomy and their Families as a genuine alternative to ICU. This model is based on the service provision of an accredited Australian Intensive Home Care service provider. The service model is based on successful Home Intensive Care services in Germany.ResultsQuality of end of Life for Patients and their Families in their own home as a genuine alternative to ICU, as well as cost effectiveness and effective resource management for ICU'sDiscussionUsing a dedicated and accredited Intensive Home Care Service provides Patients and their Families with a genuine alternative to Intensive Care whilst also freeing up expensive and scarce ICU beds.ConclusionConsidering more people want to die at home if given the choice, in combination with the continued high demand for scarce and expensive ICU beds, Intensive Home Care services are a genuine alternative for the provision of Quality of end of Life services for long term ventilated Patients and their Families.
Republished: Managing the after effects of serious patient safety incidents in the NHS: an online survey study
Authors: Pinto Anna , Faiz Omar , Vincent Charles 
Published: April 2013

AbstractObjectiveTo examine the current state of practice in English NHS Trusts in relation to the communication of serious patient safety incidents to patients and families and support for all parties involved.DesignCross-sectional design using online surveys.Participants209 patient safety managers, responsible for the ‘Being Open’ policy (54% response rate).SettingEnglish NHS Trusts.Results98% of the participants reported that they are familiar with the National Patient Safety Agency Being Open guidance and 82% that they implement it more than half the time when incidents occur. However, provision of timely information was not reported as routine, with two-thirds of the discussions taking place 3–6 weeks after the investigation. The frequency of taking responsibility for harm was low for incidents of different severity levels but significantly lower for less serious ones (p&lt;0.001). Follow-ups of patients in the long term and ex gratia payments were provided less than half the time. The most highly rated barriers to being open were clinical staff's fear of negative reactions from patients or their families and anxiety about litigation. Support practices for staff, such as debriefing and training on being open, were acknowledged as highly important but not always available.ConclusionsAwareness of the importance of being open is high among patient safety managers in English NHS Trusts, but there is still considerable scope for improvement in the management of the after effects of patient safety incidents. More research is needed on patients' and healthcare professionals' preferences for support after patient safety incidents.
DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin 
Published: April 2013

Abstract
Small cell lung cancer (SCLC) is one of the most aggressive types of cancer, yet the pathologic mechanisms underlying its devastating clinical outcome remain elusive. In this report, we surveyed 924 miRNA (miR) for their expressions in the formalin-fixed paraffin-embedded specimens from 42 patients with SCLC, and found that the downregulated miR-886-3p is closely correlated with the shorter survival of SCLC. This correlation was validated with another 40 cases. It was further discovered that loss of miR-886-3p expression was mediated by DNA hypermethylation of its promoter in both cultured SCLC cells and tumor samples. Moreover, miR-886-3p potently repressed cell proliferation, migration, and invasion of NCI-H446 cell in cell culture via suppression of the expression of its target genes: PLK1 and TGF-β1 at posttranscription levels. Forced upregulation of miR-886-3p greatly inhibited in vivo tumor growth, bone/muscle invasion, and lung metastasis of NCI-H446 cells. This newly identified miR-886-3p-PLK1/TGF-β1 nexus that modulates SCLC aggression suggests that both loss of miR-886-3p expression and hypermethylation of the miR-886 promoter are the promising indicators for poor outcome of as well as new therapeutic targets for SCLC. Cancer Res; 73(11); 3326–35. ©2013 AACR.
Relationships between Serum and Colon Concentrations of Carotenoids and Fatty Acids in Randomized Dietary Intervention Trial
Authors: Sen Ananda , Ren Jianwei , Ruffin Mack T. , Turgeon Danielle K. , Brenner Dean E. , Sidahmed Elkhansa , Rapai Mary E. , Cornellier Maria L. , Djuric Zora 
Published: April 2013

AbstractLittle is known about the effect of preventive diets on colonic nutrient concentrations. This study randomized 120 persons at increased risk of colon cancer to a Mediterranean versus a Healthy Eating diet for six months. The former targeted increases in whole grains, fruits, vegetables, monounsaturated, and n3 fats. The Healthy Eating diet was based on Healthy People 2010 recommendations. At baseline, dietary fat and carotenoid intakes were poorly associated (Spearman ρ &lt; 0.4) with serum and colon concentrations. Strong associations were observed between serum and colon measurements of β-cryptoxanthin (ρ = 0.58; P &lt; 0.001), α-carotene (ρ = 0.48; P &lt; 0.001), and β-carotene (ρ = 0.45; P &lt; 0.001). After six months, the Healthy Eating intervention increased serum lutein, β-, and α-carotene significantly (P &lt; 0.05). In the Mediterranean arm, the significant increases were in serum lutein, β-cryptoxanthin, β-carotene, monounsaturated, and n3 fats. A significant group-by-time interaction (P = 0.03) was obtained for monounsaturated fats. Colonic increases in carotenoids and n3 fats were significant only in Healthy Eating arm, whereas the group-by-time interaction was significant for β-carotene (P = 0.02) and α-carotene (P = 0.03). Changes in colon concentrations were not significantly associated with reported dietary changes. Changes in colon and serum concentrations were strongly associated for β-cryptoxanthin (ρ = 0.56; P &lt; 0.001) and α-carotene (ρ = 0.40; P &lt; 0.001). The associations between colonic and serum concentrations suggest the potential use of using serum concentration as a target in dietary interventions aimed at reducing colon cancer risk. Cancer Prev Res; 6(6); 558–65. ©2013 AACR.
Policy Diffusion in Public Procurement: The Role of Free Trade Agreements
Authors: Woolcock Steve 
Published: April 2013

Abstract
This article assesses the factors shaping policy diffusion of effective, liberal public procurement regimes. Policy diffusion and the analysis of policy diffusion is less developed in public procurement than other policy areas such as investment. This is surprising given the potential economic (public procurement accounts for some 8% of GDP) and signaling (transparency, good governance) gains of adopting regimes that promote competition in public procurement markets. The article first provides an introduction to the issue of public procurement and discusses the nature of procurement regimes, the dependent variable. It then assesses the impact of key variables identified in the literature on policy diffusion, such as competition, coercion and norm emulation. It is argued that issue linkage in bilateral free trade agreements (FTA) appears to have brought about common laws – and in some cases – rules for procurement. But this stops short of a genuine diffusion of liberal procurement regimes due to negotiations being framed by reciprocity rather than efficiency considerations, the costs and complexity of implementation, as well as opposition from vested sector interests and politicians at all levels of government favoring the short term political utility of ‘buy local’ policies.
MR features to suggest microinvasive ductal carcinoma of the breast: can it be differentiated from pure DCIS?
Authors: Hahn Soo Yeon , Han Boo-Kyung , Ko Eun Young , Shin Jung Hee , Hwang Ji-Young , Nam Meeyoung 
Published: April 2013

Background Morphologic and kinetic characteristics of breast lesions are regarded as a major criterion for their differential diagnosis in dynamic magnetic resonance imaging (MRI). However, there have not been well-reported MRI findings of microinvasive ductal carcinoma. Purpose To evaluate MRI characteristics of microinvasive ductal carcinoma of the breast and to compare MRI findings in patients with microinvasive ductal carcinoma and pure ductal carcinoma in situ (DCIS). Material and Methods Eighty-one patients with pathologically confirmed microinvasive ductal carcinomas ( n = 37) or pure DCIS ( n = 44) were included in this study. The MRI findings were analyzed without knowledge of the pathologic and conventional imaging findings. For all the lesions detected on MRI, morphologic and kinetic analyses were performed according to the Breast Imaging Reporting and Data System. For the non-mass lesions, the presence of clustered ring enhancement was also analyzed. Statistical analyses were performed using Student's t test, χ2 test, and Fisher's exact test. Results In total 35 cases of microinvasive ductal carcinoma and 39 cases of DCIS were detected on MRI. The most common and dominant MRI findings of microinvasive ductal carcinoma and DCIS were non-mass lesions with heterogeneous enhancement. However, the spiculated margin of the mass-type lesion ( P = 0.022), the segmental distribution ( P = 0.023), and clustered ring enhancement ( P = 0.006) of the non-mass-type lesion, and the enhancement kinetics showing strong initial enhancement ( P = 0.004) with subsequent wash-out ( P = 0.001) were significantly more frequent in microinvasive ductal carcinoma than in DCIS. Conclusion Non-mass lesions with segmental distribution, heterogeneous enhancement, and strong initial enhancement with a wash-out curve were the dominant MRI findings of microinvasive ductal carcinoma. Compared with DCIS, microinvasive ductal carcinoma showed more suspicious imaging characteristics. For the non-mass lesions, clustered ring enhancement was also a characteristic finding of microinvasion on MRI.
Dress and the Social Construction of Gender in Two Sororities
Authors: Arthur Linda B. 
Published: April 2013

This study sheds light on dress as it is involved in the social construction of femininity, and in particular how sororities are engaged in this process. As institutions, the sororities in this study trained their members toward a traditional notion of femininity that was visually expressed in appearance. New sorority members (pledges) were actively involved in the social construction of gender as they adopted the sororities' idealized images and roles pertaining to femininity. Enculturation into a sorority began with adoption of the idealized images such as a sorority look. Pledges wanted to at least look like full-fledged members and alleviated status insecurity by adopting the idealized image as they embraced their roles. As competing roles emerged over time, full-fledged members substituted the sorority's idealized images for personal images. Adherence to the sororities' idealized images became a gender role obligation. Benefits of this study to textiles and clothing scholarship include a deeper understanding of the role of appearance in non-verbal communication and in informal social control.
On the convexity of the function C ↦ f(det C) on positive-definite matrices
Authors: Lehmich Stephan , Neff Patrizio , Lankeit Johannes 
Published: April 2013

Let [Formula: see text]. We prove a condition on [Formula: see text] for the convexity of f ∘det on [Formula: see text], namely that f ∘det is convex on [Formula: see text] if and only if [Formula: see text] This generalizes the observation that C ↦ − ln det C is convex as a function of C.
Reliability analysis of a geographic information system-aided optimal phasor measurement unit location for smart grid operation
Authors: Ghosh Debomita , Ghose T. , Mohanta D.K. 
Published: April 2013

The conventional power system is going through a paradigm change towards smart grid, incorporating technological innovations for sensing, communicating, applying intelligence and exercising control through feedback. Recently, phasor measurement units (PMUs) have been used extensively for the purpose of sensing and communication. In many system planning studies, planners experience conflicts while taking into account the requirements related to communication systems, environment and geographic configurations owing to lack of proper spatial co-ordination. A geographic information system (GIS) provides a rich set of functions to view the power system network and to explore the geospatial relations. The main contribution of this article is to investigate the impact of topological attributes on commissioning phasor measurement units to ensure reliability through different phasor measurement unit connectivity configuration. Comparative studies have been done amongst different phasor measurement unit connectivity configuration for determining the most reliable data exchange methodology. Case studies related to the eastern grid of India corroborate the potential use of geographic information system taking pragmatic spatial aspects into account for phasor measurement unit placement.
Fev regulates hematopoietic stem cell development via ERK signaling
Authors: Wang Lu , Liu Tianhui , Xu Linjie , Gao Ya , Wei Yonglong , Duan Caiwen , Chen Guo-Qiang , Lin Shuo , Patient Roger , Zhang Bo , Hong Dengli , Liu Feng 
Published: April 2013

Key PointsFev is required for endothelium-based HSC emergence. Fev directly regulates ERK signaling to regulate HSC development cell-autonomously.
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
Authors: Rajala Hanna L. M. , Eldfors Samuli , Kuusanmäki Heikki , van Adrichem Arjan J. , Olson Thomas , Lagström Sonja , Andersson Emma I. , Jerez Andres , Clemente Michael J. , Yan Yiyi , Zhang Dan , Awwad Andy , Ellonen Pekka , Kallioniemi Olli , Wennerberg Krister , Porkka Kimmo , Maciejewski Jaroslaw P. , Loughran Thomas P. , Heckman Caroline , Mustjoki Satu 
Published: April 2013

Key Points
Somatic mutations were discovered for the first time in the SH2 domain of the STAT5b gene in LGL leukemia. The mutations are activating and lead to increased phosphorylation and transcriptional activity of STAT5b.
Factors associated with HIV infection among men who have sex with men in Henan Province, China: a cross-sectional study
Authors: Liu Jie , Qu Bo , C Ezeakile Moses , Zhang Yang , Liang Shijie 
Published: April 2013

Abstract

Background
HIV prevalence among men who have sex with men (MSM) has increased rapidly in China. Behavioral and biological interventions are key to controlling the spread of HIV in the MSM population and the primary strategy for reducing the spread of AIDS in China. The purpose of this study is to investigate the prevalence of HIV among MSM in Henan province and to assess their knowledge levels and risk behaviors related to HIV/AIDS.

Method
A cross-sectional survey was conducted among 388 MSM in 2010 in Zhengzhou City, Henan province, China.

Results
Of the 388 respondents, 13.1% were infected with HIV and 10.3% were infected with syphilis. The results of multivariate analysis showed that participants who had a history of being infected by syphilis were more than 4 times more likely to be HIV positive (AOR=4.91; 95% CI: 1.70 to 12.02). For those who were residents from other provinces, the risk of HIV infection was 5.53 times higher (OR=5.53, 95% CI: 1.14, 6.25). Receipt of condoms (AOR = 0.15; 95% CI: 0.02 to 0.87), consistent condom use during last intercourse with a male (AOR=0.35; 95% CI: 0.14 to 0.87), and consistent condom use during last intercourse with a female (AOR=0.16; 95% CI: 0.08 to 0.90) were associated with a lower risk of HIV infection.

Conclusion
The study suggests that some intervention strategies, including education intervention, condom promotion and distribution, and HIV counseling and testing are necessary to control HIV infection among MSM.
The true cost of cardiovascular imaging: focusing on downstream, indirect, and environmental costs
Authors: Braga Larissa , Vinci Bruna , Leo Carlo G , Picano Eugenio 
Published: April 2013

Abstract
To develop a more realistic assessment of costs, herein named “true” costs, the extra-cancer from medical radiation, environmental damage from imaging paraphernalia and radioactive wastes must be included as long-term costs from imaging examinations. It is urgent to define the “true” costs across imaging modalities as it interferes on physicians’ decision to request an exam and on research projects such as cost-effectiveness analysis. Cardiology is the specialty that most will benefit from the outcome as cardiovascular exams represent almost 30% of the total exams acquired annually worldwide.
The ion implantation-induced properties of one-dimensional nanomaterials
Authors: Li Wen Qing , Xiao Xiang Heng , Stepanov Andrey L , Dai Zhi Gao , Wu Wei , Cai Guang Xu , Ren Feng , Jiang Chang Zhong 
Published: April 2013

Abstract
Nowadays, ion implantation is an extensively used technique for material modification. Using this method, we can tailor the properties of target materials, including morphological, mechanical, electronic, and optical properties. All of these modifications impel nanomaterials to be a more useful application to fabricate more high-performance nanomaterial-based devices. Ion implantation is an accurate and controlled doping method for one-dimensional nanomaterials. In this article, we review recent research on ion implantation-induced effects in one-dimensional nanostructure, such as nanowires, nanotubes, and nanobelts. In addition, the optical property of single cadmium sulfide nanobelt implanted by N+ ions has been researched.
Controllable synthesis of MnO2/polyaniline nanocomposite and its electrochemical capacitive property
Authors: Meng Fanhui , Yan Xiuling , Zhu Ye , Si Pengchao 
Published: April 2013

Abstract
Polyaniline (PANI) and MnO2/PANI composites are simply fabricated by one-step interfacial polymerization. The morphologies and components of MnO2/PANI composites are modulated by changing the pH of the solution. Formation procedure and capacitive property of the products are investigated by XRD, FTIR, TEM, and electrochemical techniques. We demonstrate that MnO2 as an intermedia material plays a key role in the formation of sample structures. The MnO2/PANI composites exhibit good cycling stability as well as a high capacitance close to 207 F g−1. Samples fabricated with the facile one-step method are also expected to be adopted in other field such as catalysis, lithium ion battery, and biosensor.
Existence of solutions for a class of degenerate quasilinear elliptic equation in "Equation missing" with vanishing potentials
Authors: Bastos Waldemar D , Miyagaki Olimpio H , Vieira Rônei S 
Published: April 2013

Abstract
We establish the existence of positive solution for the following class of degenerate quasilinear elliptic problem

(
P
)

{

−
L

u

a
p

+
V
(
x
)

|
x
|

−
a

p
∗

|
u
|

p
−
2

u
=
f
(
u
)

in

R
N

,

u
>
0

in

R
N

;

u
∈

D
a

1
,
p

(

R
N

)
,

where

−
L

u

a
p

=
−
div
(

|
x
|

−
a
p

|
∇
u
|

p
−
2

∇
u
)

,

1
<
p
<
N

,

−
∞
<
a
<

N
−
p

p

,

a
≤
e
≤
a
+
1

,

d
=
1
+
a
−
e

, and

p
∗

:
=

p
∗

(
a
,
e
)
=

N
p

N
−
d
p

denote the Hardy-Sobolev’s critical exponent, V is a bounded nonnegative vanishing potential and f has a subcritical growth at infinity. The technique used here is a truncation argument together with the variational approach.

MSC:35B09, 35J10, 35J20, 35J70.