bluuebunny/crossref_metadata_2025_split huggingface dataset:
Citrus Consumption and Risk of Cutaneous Malignant Melanoma
Authors: Wu Shaowei , Han Jiali , Feskanich Diane , Cho Eunyoung , Stampfer Meir J. , Willett Walter C. , Qureshi Abrar A. 
Published: June 2015

Purpose Citrus products are widely consumed foods that are rich in psoralens and furocoumarins, a group of naturally occurring chemicals with potential photocarcinogenic properties. We prospectively evaluated the risk of cutaneous malignant melanoma associated with citrus consumption. Methods A total of 63,810 women in the Nurses' Health Study (1984 to 2010) and 41,622 men in the Health Professionals Follow-Up Study (1986 to 2010) were included. Dietary information was repeatedly assessed every 2 to 4 years during follow-up. Incident melanoma cases were identified through self-report and confirmed by pathologic records. Results Over 24 to 26 years of follow-up, we documented 1,840 incident melanomas. After adjustment for other risk factors, the pooled multivariable hazard ratios for melanoma were 1.00 for overall citrus consumption < twice per week (reference), 1.10 (95% CI, 0.94 to 1.30) for two to four times per week, 1.26 (95% CI, 1.08 to 1.47) for five to six times per week, 1.27 (95% CI, 1.09 to 1.49) for once to 1.5 times per day, and 1.36 (95% CI, 1.14 to 1.63) for ≥ 1.6 times per day (Ptrend < .001). Among individual citrus products, grapefruit showed the most apparent association with risk of melanoma, which was independent of other lifestyle and dietary factors. The pooled multivariable hazard ratio for melanoma comparing the extreme consumption categories of grapefruit (≥ three times per week v never) was 1.41 (95% CI, 1.10 to 1.82; Ptrend < .001). Conclusion Citrus consumption was associated with an increased risk of malignant melanoma in two cohorts of women and men. Nevertheless, further investigation is needed to confirm our findings and explore related health implications.
Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury
Authors: Ashton Anthony W. , Le Thi Y. L. , Gomez-Sanchez Celso E. , Morel-Kopp Marie-Christine , McWhinney Brett , Hudson Amanda , Mihailidou Anastasia S. 
Published: June 2015

Abstract
Aldosterone (Aldo) activates both genomic and nongenomic signaling pathways in the cardiovascular system. Activation of genomic signaling pathways contributes to the adverse cardiac actions of Aldo during reperfusion injury; however, the extent nongenomic signaling pathways contribute has been difficult to identify due to lack of a specific ligand that activates only nongenomic signaling pathways. Using a pegylated aldosterone analog, aldosterone-3-carboxymethoxylamine-TFP ester conjugated to methoxypegylated amine (Aldo-PEG), we are able for the first time to distinguish between nongenomic and genomic cardiac actions of Aldo. We confirm Aldo-PEG activates phosphorylation of ERK1/2 in rat cardiomyocyte H9c2 cells similar to Aldo and G protein-coupled receptor 30 (GPR30 or GPER) agonist G1. GPER antagonist, G36, but not mineralocorticoid receptor (MR) antagonist spironolactone, prevented ERK1/2 phosphorylation by Aldo, Aldo-PEG, and G1. The selective nongenomic actions of Aldo-PEG are confirmed, with Aldo-PEG increasing superoxide production in H9c2 cells to similar levels as Aldo but having no effect on subcellular localization of MR. Striatin serves as a scaffold for GPER and MR, with GPER antagonist G36, but not spironolactone, restoring MR-striatin complexes. Aldo-PEG had no effect on MR-dependent transcriptional activation, whereas Aldo increased transcript levels of serum-regulated kinase 1 and plasminogen activator inhibitor-1. Using our ex vivo experimental rat model of myocardial infarction, we found aggravated infarct size and apoptosis by Aldo but not Aldo-PEG. Our studies confirm that in the heart, activation of nongenomic signaling pathways alone are not sufficient to trigger the deleterious effects of aldosterone during myocardial reperfusion injury.
Accountable Care Organizations: Integrated Care Meets Market Power
Authors: Scheffler Richard M. 
Published: June 2015

Abstract
Will accountable care organizations (ACOs) deliver high-quality care at lower costs? Or will their potential market power lead to higher prices and lower quality? ACOs appear in various forms and structures with financial and clinical integration at their core; however, the tools to assess their quality and the incentive structures that will determine their success are still evolving. Both market forces and regulatory structures will determine how these outcomes emerge. This introduction reviews the evidence presented in this special issue to tackle this thorny trade-off. In general the evidence is promising, but the full potential of ACOs to improve the health care delivery system is still uncertain. This introductory review concludes that the current consensus is to let ACOs grow, anticipating that they will make a contribution to improve our poor-quality and high-cost delivery system.
Owusu-Ankomah Microcron Begins
Authors: Hynes NJ 
Published: June 2015

Owusu-Ankomah has long drawn on Ghanaian adrinka symbols as motifs for his paintings. Over the years he has added other signs to his repertoire, ranging from Chinese characters and crop-circle schemata to invented signs and, even, snowflakes. In Microcron Begins, his second solo exhibition at the October Gallery in London, he has narrowed in on one self-invented sign, the “microcron”—a circlet of dots or globes—as the focal point of his symbolic system. But is the microcron visually interesting enough to hold this dominant position?
In his strongest pieces, which have historically been black-and-white, he pushes the relationship between the figures and the symbols further. He also uses two figures rather than one, generating a sense of energy and depth. But some recent paintings included in this exhibition show a dramatic shift into color, an emphasis on tone rather than line, and a more hierarchical composition. These works seem transitional, as if he is feeling his way toward pieces that are more spacious, sparse, and potentially introspective. Now that he is in his fifties, there is a synthesis in his thought that is looking for new outlets in his visual work. But one hopes he won’t leave the linear strength and dynamism of his black-and-white compositions behind.
Can Marketing Campaigns Induce Multichannel Buying and More Profitable Customers? A Field Experiment
Authors: Montaguti Elisa , Neslin Scott A. , Valentini Sara 
Published: June 2015

One of the most intriguing findings in the multichannel customer management literature is the positive association between multichannel purchasing and customer profitability. The question is whether this finding can be put into action. That is, can a firm develop a marketing campaign to increase multichannel purchasing and hence average customer profitability, and if so what are the key factors that enable success. We design and implement a randomized field experiment to investigate this question. The field experiment tests four marketing campaigns that vary in the communications message and the provision of financial incentives. We find that the multichannel/profitability relationship is actionable. A properly designed marketing campaign increases the number of multichannel customers and increases average customer profitability. That campaign’s message emphasizes the benefits of multichannel shopping but does not rely on financial incentives. Moreover, we use propensity score matching to show that, after accounting for self-selection, multichannel customers are more profitable than they would be if they were not multichannel. A post-test analysis suggests that the multichannel/nonfinancial incentive campaign succeeded in inducing customers to become multichannel because it decreased customer reactance and increased perceived behavioral control. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mksc.2015.0923 .
Functional and radiological outcome of periprosthetic fractures of the ankle
Authors: Tsitsilonis S. , Schaser K. D. , Wichlas F. , Haas N. P. , Manegold S. 
Published: June 2015

The incidence of periprosthetic fractures of the ankle is increasing. However, little is known about the outcome of treatment and their management remains controversial. The aim of this study was to assess the impact of periprosthetic fractures on the functional and radiological outcome of patients with a total ankle arthroplasty (TAA).A total of 505 TAAs (488 patients) who underwent TAA were retrospectively evaluated for periprosthetic ankle fracture: these were then classified according to a recent classification which is orientated towards treatment. The outcome was evaluated clinically using the American Orthopedic Foot and Ankle Society (AOFAS) score and a visual analogue scale for pain, and radiologically.A total of 21 patients with a periprosthetic fracture of the ankle were identified. There were 13 women and eight men. The mean age of the patients was 63 years (48 to 74). Thus, the incidence of fracture was 4.17%.There were 11 intra-operative and ten post-operative fractures, of which eight were stress fractures and two were traumatic. The prosthesis was stable in all patients. Five stress fractures were treated conservatively and the remaining three were treated operatively.A total of 17 patients (81%) were examined clinically and radiologically at a mean follow-up of 53.5 months (12 to 112). The mean AOFAS score at follow-up was 79.5 (21 to 100). The mean AOFAS score in those with an intra-operative fracture was 87.6 (80 to 100) and for those with a stress fracture, which were mainly because of varus malpositioning, was 67.3 (21 to 93). Periprosthetic fractures of the ankle do not necessarily adversely affect the clinical outcome, provided that a treatment algorithm is implemented with the help of a new classification system.Cite this article: Bone Joint J 2015;97-B:950–6.
Long-term patient-reported outcomes following Bennett’s fractures
Authors: Middleton S. D. , McNiven N. , Griffin E. J. , Anakwe R. E. , Oliver C. W. 
Published: June 2015

We define the long-term outcomes and rates of further operative intervention following displaced Bennett’s fractures treated with Kirschner (K-) wire fixation between 1996 and 2009. We retrospectively identified 143 patients (127 men and 16 women) with a mean age at the time of injury of 33.2 years (18 to 75). Electronic records were examined and patients were invited to complete the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire in addition to a satisfaction questionnaire. The time since injury was a mean of 11.5 years (3.4 to 18.5). In total 11 patients had died, one had developed dementia and 12 patients were lost to follow-up. This left 119 patients available for recruitment. Of these, 57 did not respond, leaving a study group of 62 patients. Patients reported excellent functional outcomes and high levels of satisfaction at follow-up. Median satisfaction was 94% (interquartile range 91.5 to 97.5) and the mean DASH score was 3.0 (0 to 38). None of the patients had undergone salvage procedures and none of the responders had changed occupation or sporting activities. Long-term patient reported outcomes following displaced Bennett’s fractures treated by closed reduction and K-wire fixation show excellent functional results and a high level of patient satisfaction. The rate of infection is low and similar to other surgical procedures with percutaneous K-wires. Cite this article: Bone Joint J 2015;97-B:1004–6.
Relationship between Serum Testosterone and Fracture Risk in Men: A Comparison of RIA and LC-MS/MS
Authors: Tran Thach S , Center Jacqueline R , Seibel Markus J , Eisman John A , Kushnir Mark M , Rockwood Alan L , Nguyen Tuan V 
Published: June 2015

Abstract

BACKGROUND
Serum testosterone can be measured by LC-MS/MS and RIA. We investigated whether the testosterone–fracture relationship was affected by the method of measurement.

METHODS
We measured total testosterone (TT) by LC-MS/MS (TTLC-MS/MS) and RIA (TTRIA) in serum samples collected from 602 men whose incident fractures had been continuously ascertained by x-ray reports from 1989 to 2010. We measured bone mineral density (BMD) by dual-energy x-ray absorptiometry. The association between TT and fracture risk was assessed by the Cox proportional hazards model, taking into account the effect of age and BMD.

RESULTS
Mean TTLC-MS/MS was higher than TTRIA by 27 ng/dL (95% CI 13–41). The concordance correlation coefficient between TTLC-MS/MS and TTRIA was 0.72 (95% CI 0.68–0.76). The Deming regression equation linking the 2 measurements was ln(TTLC-MS/MS + 10) = 0.87 + 0.87 × ln(TTRIA + 10). The hazard ratio of fracture per SD decrease in TT was 1.32 (95% CI 1.12–1.54) for TTLC-MS/MS and 1.23 (1.06–1.43) for TTRIA. The correlation between predicted probabilities of fracture by TTLC-MS/MS and TTRIA was r = 0.96, with the mean difference being 0.01% (95% CI −6.1% to 6.2%). Slightly more patients were classified as having hypogonadism if TTRIA was used (29% vs 26%).

CONCLUSIONS
The concordance between LC-MS/MS and RIA in the measurement of serum TT was moderate. Moreover, the magnitude of association between testosterone and fracture risk in older men was largely unaffected by the method of measurement.
La comunicación financiera responsable a través de Internet y de las redes sociales
Authors: Mazza Bárbara 
Published: June 2015

El ensayo se focaliza en el estudio de la responsabilidad social de la empresa centrándose en la comunicación económica – financiera. En los últimos treinta años, la comunicación económica-financiera se ha vuelto estratégica para la gestión cotidiana de las empresas y, no solo, para aquellas que cotizan en la Bolsa. En su evolución, la dimensión de la comunicación dedicada a la economía y a las finanzas, no se dirige solo a los inversionistas, sino también se extiende a todos los públicos, buscando mayor transparencia y previendo la implicación participativa de los stakeholders. Los contenidos se caracterizan por ser únicamente económicos, regulados por las normativas nacionales e internacionales, utilizan la información y la narración para reconstruir los procesos, las historias y los valores de la organización. Los elementos de la responsabilidad social de la empresa expresan el valor, la credibilidad y la identidad misma del gobierno corporativo. El ensayo presenta un análisis de las modalidades comunicativas adoptadas por las empresas europeas líderes en los mercados financieros internacionales, centrándose en el estudio del contenido, las herramientas y las estrategias de comunicación.
Symulacja efektów rozdrabniania w prasie walcowej dla materiału o zmiennej zawartości ziaren drobnych / Simulation of Comminution Effects in HPGR for the Feed Material Variable Content of Fine Particles
Authors: Saramak Daniel 
Published: June 2015

Streszczenie
W artykule przedstawione zostały wyniki badań dotyczących procesów rozdrabniania w prasie walcowej dla rud miedzi. Przeprowadzono próby kruszenia w laboratoryjnej prasie walcowej dla materiału o zmiennej zawartości najdrobniejszych klas ziarnowych, mianowicie: od 0 do 6 mm, od 0,3 do 6 mm, od 1,5 do 6mm oraz od2,5 do 6mm. Próby przeprowadzono dla materiałuo wilgotności naturalnej (tj. blisko 0%) oraz 2%. Uzyskane w tym zakresie wyniki pokazują, że dla materiału wilgotnego efektywność rozdrabniania nieznacznie się zmniejszyła, również pozbawianie nadawy kolejnych drobnych klas ziarnowych miało swój efekt w mniejszym stopniu rozdrobnienia produktów HPGR, jednak w miarę dalszego zwiększania wilgotności nadawy wskaźniki wydajności oraz energo- chłonności procesu uległy pogorszeniu.
Analizując parametry pracy wysokociśnieniowej prasy walcowej można stwierdzić, że zwięk- szenie wilgotności nieznacznie zwiększa wydajność procesu, również w niewielkim stopniu redukując jego energochłonność.
Jednym z praktycznych efektów była próba opisu krzywych składu ziarnowego produktów rozdrabniania HPGR o zmiennym uziarnieniu nadawy za pomocą teoretycznej dystrybuanty Weibulla oraz powiązanie parametrów we wzorze aproksymującym z poziomem usunięcia drobnych klas ziarnowych nadawy. Wyniki aproksymacji pokazują, że dystrybuanta Weibulla opisuje produkty rozdrabniania z błędem dopasowania poniżej 4%. Z kolei aproksymacja z powiązaniem parametrów wzoru aproksymującego ze stopniem usunięcia drobnych klas ziarnowych charakteryzowała się błędem dopasowania przekraczającym minimalnie 5% przy najgorszym dopasowaniu, natomiast najdokładniejsze dopasowanie miało błąd poniżej 4%. Uzyskane wyniki pozwoliły na określenie zależności pomiędzy właściwościami nadawy a przebiegiem procesu rozdrabniania rudy miedzi w wysokociśnieniowej prasie walcowej oraz jego efektywnością mierzoną wskaźnikami techno- logicznymi i ekonomicznymi.
The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging
Authors: Panickar Kiran S. , Jewell Dennis E. 
Published: June 2015

AbstractAging in humans is associated with chronic low-grade inflammation (systemic), and this condition is sometimes referred to as “inflammaging”. In general, canines also age similarly to humans, and such aging is associated with a decline in mobility, joint problems, weakened muscles and bones, reduced lean body mass, cancer, increased dermatological problems, decline in cognitive ability, reduced energy, decreased immune function, decreased renal function, and urinary incontinence. Each of these conditions is also associated with an increase in pro-inflammatory cytokines. An inflammatory state characterized by an increase in pro-inflammatory markers including but not restricted to tumor necrosis factor-α, interleukin-6, IL-1β, and C-reactive protein (CRP) is believed to contribute to or worsen a general decline in biological mechanisms responsible for physical function with aging. Nutritional management of inflammation in aging dogs is important in maintaining health. In particular, natural botanicals have bioactive components that appear to have robust anti-inflammatory effects and, when included in the diet, may contribute to a reduction in inflammation. While there are scientific data to support the anti-inflammatory effects and the efficacy of such bioactive molecules from botanicals, the clinical data are limited and more studies are needed to validate the efficacy of these ingredients. This review will summarize the role of dietary ingredients in reducing inflammatory molecules as well as review the evidence available to support the role of diet and nutrition in reducing chronic low-grade systemic inflammation in animal and human studies with a special reference to canines, where possible.
Osmotic Dehydration of Tomato Assisted by Ultrasound: Evaluation of the Liquid Media on Mass Transfer and Product Quality
Authors: Corrêa Jefferson L. G. , Justus Ariana , de Oliveira Letícia F. , Alves Guilherme E. 
Published: June 2015

Abstract
The treatment of a food in liquid media involves mass transfer and could aid to preserve some food properties. The assistance of ultrasound (US) could even improve the process. Therefore, the aim of this study was to evaluate US (frequency 25 kHz, powder intensity 8 kW m–3) in tomato treatment in sucrose and NaCl solutions, common osmotic agents. Moreover, for testing the influence of the media, distilled water and maltodextrin solution completed the set of tested liquids. Water loss (WL), solid gain (SG), water activity (a
w), color parameters, like the total color difference (ΔE) and microstructure were evaluated. The advantages of NaCl and sucrose solutions were the high WL and SG values besides low a
w and ΔE. The alterations in the microstructure of US-treated samples in distilled water or maltodextrin suggested that a product with low solid incorporation and reduced drying time could be obtained in a further drying.
The Institutional and External Factors Behind the Switch of a Country’s Economic Growth Strategy. The Case of the Brazilian Economic Policy
Authors: Czarnecka-Gallas Marta 
Published: June 2015

Abstract
One of the most important tasks for Brazil after the Second World War was to change the structure of its economy. Due to a relatively low level of domestic industry, consecutive governments found industrialization the main priority and focused on industrial policy to foster that process. One can argue that industrial policy was the core element of Brazilian economic policy throughout the post-war period, until the liberalization reforms of the 1980 s. Political and economic traditions, together with rapid changes in global economy over the last decades, have had a huge impact on more recent Brazilian economic policy. On one hand, the country has kept looking back to the protectionist practices that have shaped its economy since the emergence of the modern Brazilian state, on the other, Brazil’s ambition is to become a leading emerging economy and serious partner in the developed world. A dual development track, and continuous inner-conflict between protectionism and liberalism, is clearly visible in Brazilian economic policy and often leads to contradictory measures being taken by successive governments. The objectives of the article is to provide a contextualized analysis of the evolution of Brazil’s economic growth strategy, with a particular focus on the role of economic and political traditions, and institutions.
Accuracy of unmodified Stokes’ integration in the R-C-R procedure for geoid computation
Authors: Ismail Zahra , Jamet Olivier 
Published: June 2015

AbstractGeoid determinations by the Remove-Compute-­Restore (R-C-R) technique involves the application of Stokes’ integral on reduced gravity anomalies. Numerical Stokes’ integration produces an error depending on the choice of the integration radius, grid resolution and Stokes’ kernel function.In this work, we aim to evaluate the accuracy of Stokes’ integral through a study on synthetic gravitational signals derived from EGM2008 on three different landscape areas with respect to the size of the integration domain and the resolution of the anomaly grid. The influence of the integration radius was studied earlier by several authors. Using real data, they found that the choice of relatively small radii (less than 1°) enables to reach an optimal accuracy. We observe a general behaviour coherent with these earlier studies. On the other hand, we notice that increasing the integration radius up to 2° or 2.5° might bring significantly better results. We note that, unlike the smallest radius corresponding to a local minimum of the error curve, the optimal radius in the range 0° to 6° depends on the terrain characteristics. We also find that the high frequencies, from degree 600, improve continuously with the integration radius in both semi-­mountainous and mountain areas.Finally, we note that the relative error of the computed geoid heights depends weakly on the anomaly spherical harmonic degree in the range from degree 200 to 2000. It remains greater than 10 % for any integration radii up to 6°. This result tends to prove that a one centimetre accuracy cannot be reached in semi-mountainous and mountainous regions with the unmodified Stokes’ kernel.