bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of facial skeletal shape variation in fibroblast growth factor receptor‐related craniosynostosis syndromes
Authors: Heuzé Yann , Martínez‐Abadías Neus , Stella Jennifer M. , Arnaud Eric , Collet Corinne , García Fructuoso Gemma , Alamar Mariana , Lo Lun‐Jou , Boyadjiev Simeon A. , Di Rocco Federico , Richtsmeier Joan T. 
Published: February 2014

Backgroundfibroblast growth factor receptor (FGFR) ‐related craniosynostosis syndromes are caused by many different mutations within FGFR‐1, 2, 3, and certain FGFR mutations are associated with more than one clinical syndrome. These syndromes share coronal craniosynostosis and characteristic facial skeletal features, although Apert syndrome (AS) is characterized by a more dysmorphic facial skeleton relative to Crouzon (CS), Muenke (MS), or Pfeiffer syndromes.MethodsHere we perform a detailed three‐dimensional evaluation of facial skeletal shape in a retrospective sample of cases clinically and/or genetically diagnosed as AS, CS, MS, and Pfeiffer syndrome to quantify variation in facial dysmorphology, precisely identify specific facial features pertaining to these four syndromes, and further elucidate what knowledge of the causative FGFR mutation brings to our understanding of these syndromes.ResultsOur results confirm a strong correspondence between genotype and facial phenotype for AS and MS with severity of facial dysmorphology diminishing from Apert FGFR2S252W to Apert FGFR2P253R to MS. We show that AS facial shape variation is increased relative to CS, although CS has been shown to be caused by numerous distinct mutations within FGFRs and reduced dosage in ERF.ConclusionOur quantitative analysis of facial phenotypes demonstrate subtle variation within and among craniosynostosis syndromes that might, with further research, provide information about the impact of the mutation on facial skeletal and nonskeletal development. We suggest that precise studies of the phenotypic consequences of genetic mutations at many levels of analysis should accompany next‐generation genetic research and that these approaches should proceed cooperatively. Birth Defects Research (Part A) 100:250–259, 2014. © 2014 Wiley Periodicals, Inc.
Risk‐stratified patients with resectable soft tissue sarcoma benefit from epirubicin‐based adjuvant chemotherapy
Authors: Schenone Aaron D. , Luo Jingqin , Montgomery Luke , Morgensztern Daniel , Adkins Douglas R. , Van Tine Brian A. 
Published: February 2014

AbstractAs adjuvant chemotherapy (AC) for soft tissue sarcomas is controversial, we performed a retrospective analysis of patients seen at Washington University in St. Louis to evaluate whether it benefited our patient population. Patients were risk‐assessed using the Memorial Sloan Kettering Predictive Nomogram (MSKPN). We defined high‐risk patients by a MSKPN 4‐year postoperative probability of sarcoma‐specific death of ≥0.3 and investigated if they benefited from AC. Retrospective review was performed on patients seen between 15 February 1996 and 6 February 2010. A propensity score method in the logistic regression framework was used to model the likelihood of receiving AC. To make causal inference on the effect of AC on survival outcomes, a propensity score inverse probability of treatment weighting approach was applied to survival analysis. Overall, 135 high‐grade patients were assessed, 33 were treated with Ifosfamide/Epirubicin (I/Epi) and 102 were non AC patients. The stratified MSKPN risk was not significantly associated with any survival endpoint in the whole cohort, but trended for overall survival (OS) when evaluated against non AC patients. After adjustment for MSKPN risk and other variables, patients not receiving chemotherapy had significantly worse OS, recurrent free survival, and disease‐specific survival (DSS) with adjusted hazard ratios of 4.18 (95% CI: 2.22–7.90), 8.96 (95% CI: 3.85–20.83), and 5.42 (95% CI: 2.09–14.06), respectively. In retrospective analyses, risk‐stratified patients with soft tissue sarcoma benefited from I/Epi‐based AC. Randomized I/Epi versus I/Doxorubicin clinical trials may determine the optimal adjuvant treatment.
Dry Polymerization of 3′,5′‐Cyclic GMP to Long Strands of RNA
Authors: Morasch Matthias , Mast Christof B. , Langer Johannes K. , Schilcher Pierre , Braun Dieter 
Published: February 2014

AbstractRecent progress in the synthesis of nucleotides from prebiotically plausible precursors has opened up new ways to explain the origin of genetic matter. Mechanisms for the polymerization of nucleotides without the help of catalysts are, however, rare. Complementary to the experiments done by Costanzo et al., we found that drying 3′,5′‐cyclic GMP leads to poly‐G RNA strands with lengths of up to 40 nucleotides. We also show that the polymerization to long RNA strands is considerably more efficient under dry conditions than for cGMP polymerization in water. The length depends on the incubation time of dry nucleotides at temperatures of 40–80 °C. No enzymes or other catalysts are needed for successful polymerization.
Nickel‐Catalyzed Synthesis of N‐Aryl‐1,2‐dihydropyridines by [2+2+2] Cycloaddition of Imines with Alkynes through T‐Shaped 14‐Electron Aza‐Nickelacycle Key Intermediates
Authors: Hoshimoto Yoichi , Ohata Tomoya , Ohashi Masato , Ogoshi Sensuke 
Published: February 2014

AbstractDespite there being a straightforward approach for the synthesis of 1,2‐dihydropyridines, the transition‐metal‐catalyzed [2+2+2] cycloaddition reaction of imines with alkynes has been achieved only with imines containing an N‐sulfonyl or ‐pyridyl group. Considering the importance of 1,2‐dihydropyridines as useful intermediates in the preparation of a wide range of valuable organic molecules, it would be very worthwhile to provide novel strategies to expand the scope of imines. Herein we report a successful expansion of the scope of imines in nickel‐catalyzed [2+2+2] cycloaddition reactions with alkynes. In the presence of a nickel(0)/PCy3 catalyst, a reaction with N‐benzylidene‐P,P‐diphenylphosphinic amide was developed. Moreover, an application of N‐aryl imines to the reaction was also achieved by adopting N‐heterocyclic carbene ligands. The isolation of an (η2‐N‐aryl imine)nickel(0) complex containing a 14‐electron nickel(0) center and a T‐shaped 14‐electron five‐membered aza‐nickelacycle is shown. These would be considered as key intermediates of the reaction. The structure of these complexes was unambiguously determined by NMR spectroscopy and X‐ray analyses.
ChemInform Abstract: Mild Hydrothermal Synthesis, Isomorphous Substitution, Crystal Structure Characterization and Magnetic Properties of BaMP2O7 (M: Mn, Cu).
Authors: Lopes Armandina M. L. , Oliveira Goncalo N. P. , Ferdov Stanislav 
Published: February 2014

AbstractThe title compounds and Ba(Mn0.66Cu0.34)P2O7 are hydrothermally synthesized from aqueous mixtures of BaCl2, MnCl2 and/or CuCl2, and NaH2(PO4) (autoclave, 230 °C, 48 h).
ChemInform Abstract: Fructose‐6‐phosphate Aldolases as Versatile Biocatalysts for Nitrocyclitol Syntheses.
Authors: Bres Flora Camps , Guerard‐Helaine Christine , Fernandes Carlos , Castillo Jose A. , Lemaire Marielle 
Published: February 2014

AbstractThe efficient and stereoselective synthesis of the title compounds can be realized via a biocatalyzed aldol reaction.
ChemInform Abstract: Electrophilic Rearrangements of Chiral Amides: A Traceless Asymmetric α‐Allylation.
Authors: Peng Bo , Geerdink Danny , Maulide Nuno 
Published: February 2014

AbstractThe intermediate chiral iminium ethers, generated in situ via Claisen rearrangement of chiral amides, are directly converted into enantioenriched α‐allyl carboxylic acids or aldehydes.
ChemInform Abstract: Ruthenium‐Catalyzed Transfer Hydrogenation of Amino‐ and Amido‐Substituted Acetophenones.
Authors: Watson Andrew J. A. , Fairbanks Antony J. 
Published: February 2014

AbstractThe use of 1,4‐dibutanediol as an irreversible reducing agent is crucial to improve the conversions in the title reactions.
ChemInform Abstract: Asymmetric syn‐Aldol Reaction of α‐Hydroxy Ketones with Tertiary Amine Catalysts.
Authors: Bas Sebastian , Wozniak Lukasz , Cygan Judyta , Mlynarski Jacek 
Published: February 2014

AbstractThe title reaction extends the scope of organocatalytic processes to aromatic α‐hydroxy ketones, which have been hitherto unreactive towards enamine catalysis.
ChemInform Abstract: Synthesis of Cyclic Guanidines via Pd‐Catalyzed Alkene Carboamination.
Authors: Zavesky Blane P. , Babij Nicholas R. , Fritz Jonathan A. , Wolfe John P. 
Published: February 2014

AbstractAn efficient access to a variety of cyclic guanidines in only two steps from readily available allylic amines is described.
ChemInform Abstract: Amine‐Bridged Bis(phenol) Ligands for Efficient Pd‐Catalyzed Aqueous C—C Coupling Reactions.
Authors: Zhou Zhonggao , Liu Minyan , Wu Xiaoli , Yu Hongwei , Xu Guohai , Xie Yongrong 
Published: February 2014

AbstractA highly efficient protocol for the Pd‐catalyzed homocoupling of arylboronic acids (I) as well as Suzuki—Miyaura reactions in aqueous media is developed.
ChemInform Abstract: Effective Binuclear Pd(II) Complexes for Suzuki Reactions in Water.
Authors: Hanhan Murat Emre , Cetinkaya Cemil , Shaver Michael P. 
Published: February 2014

AbstractA series of new ionic binuclear Pd(II) complexes supported by water‐soluble bis(α‐diimine) ligands are prepared and applied as catalyst in the title reaction.
ChemInform Abstract: Palladium‐Catalyzed Direct Acylation of Ketoximes and Aldoximes from the Alcohol Oxidation Level Through C—H Bond Activation.
Authors: Sharma Satyasheel , Kim Minyoung , Park Jihye , Kim Mirim , Kwak Jong Hwan , Jung Young Hoon , Oh Joa Sub , Lee Youngil , Kim In Su 
Published: February 2014

AbstractThe title reaction represents a catalytic alternative to classical Friedel‐Crafts acylation and proceeds with excellent levels of regio‐ and chemoselectivity and high functional group tolerance.
ChemInform Abstract: Synthesis, Antibacterial and Antifungal Activity of 2‐Amino‐1,4‐naphthoquinones Using Silica‐Supported Perchloric Acid (HClO4—SiO2) as a Mild, Recyclable and Highly Efficient Heterogeneous Catalyst.
Authors: Sharma Upendra , Katoch Deepali , Sood Swati , Kumar Neeraj , Singh Bikram , Thakur Archana , Gulati Arvind 
Published: February 2014

AbstractSilica‐supported perchloric acid is found to be an efficient catalyst for the synthesis of 2‐amino‐1,4‐naphthoquinones (III) (19 examples) via conjugate addition of primary and secondary amines to 1,4‐naphthoquinone under ultrasonication.
ChemInform Abstract: An Efficient Method for the Heck—Catellani Reaction of Aryl Halides.
Authors: Wu Xiaojin , Zhou Jianrong 
Published: February 2014

AbstractAn improved method for the synthesis of Catellani—Heck isomers from various aryl halides such as (II), including ones without ortho‐substituents and bicyclic olefins is reported.
ChemInform Abstract: Synthesis and Luminescence Properties of Biphenyl‐Type Firefly Luciferin Analogues with a New, Near‐Infrared Light‐Emitting Bioluminophore.
Authors: Miura Chihiro , Kiyama Masahiro , Iwano Satoshi , Ito Kazuto , Obata Rika , Hirano Takashi , Maki Shojiro , Niwa Haruki 
Published: February 2014

AbstractThe firefly luciferin analog (IIIa) shows high bioluminescence activity with a maximum at 675 nm.
ChemInform Abstract: Three‐Component Assembly of 5‐Halo‐1,2,3‐triazoles via Aerobic Oxidative Halogenation.
Authors: Li Lingjun , Hao Guoliang , Zhu Anlian , Liu Sangui , Zhang Guisheng 
Published: February 2014

AbstractThe method applies a green and inexpensive oxidant (oxygen) and a non‐oxidative additive and can be applied to a wide range of substrates, including sugars.
ChemInform Abstract: Ring‐Expansion Reaction of Isatins with Ethyl Diazoacetate Catalyzed by Dirhodium(II)/DBU Metal‐Organic System: En Route to Viridication Alkaloids.
Authors: Paterna Roberta , Andre Vania , Duarte M. Teresa , Veiros Luis F. , Candeias Nuno R. , Gois Pedro M. P. 
Published: February 2014

AbstractA sequential process for the Eistert ring expansion of isatins with ethyl diazoacetate is developed consisting of a DBU‐promoted addition of the diazoester to the isatin 3‐carboxy group followed by Rh(II)‐catalyzed diazo decomposition of the isatin diazo intermediate.
ChemInform Abstract: Cesium Carbonate Mediated Borylation of Aryl Iodides with Diboron in Methanol.
Authors: Zhang Jieming , Wu Hai‐Hong , Zhang Junliang 
Published: February 2014

AbstractA transition‐metal free borylation of aryl iodides is readily achieved with diboranes (II) and (V) in the presence of cesium carbonate to give arylboronic ethers in moderate yields.
ChemInform Abstract: A Practical Synthetic Approach to Chiral (α‐Chloroalkyl)boronic Esters via Iridium‐Catalyzed Chemoselective Hydrogenation of Chloro‐Substituted Alkenyl Boronates.
Authors: Roseblade Stephen J. , Casas‐Arce Eva , Nettekoven Ulrike , Gazic Smilovic Ivana , Zanotti‐Gerosa Antonio , Casar Zdenko 
Published: February 2014

AbstractThe use of a chiral iridium P,N‐complex as catalyst allows the synthesis of (α‐chloroalkyl)boronic esters with up to 94% ee accompanied by small amounts of dechlorination products.
ChemInform Abstract: Structure—Activity Relationships of Lanostane‐Type Triterpenoids from Ganoderma lingzhi as α‐Glucosidase Inhibitors.
Authors: Fatmawati Sri , Kondo Ryuichiro , Shimizu Kuniyoshi 
Published: February 2014

AbstractCompound (I) is found to posses the strongest α‐glucosidase inhibitory activity among nineteen lanostane‐type triterpenoids evaluated.
ChemInform Abstract: NaBH3CN and Other Systems as Substitutes of Tin and Silicon Hydrides in the Light or Heat‐Initiated Reduction of Halosugars: A Tunable Access to Either 2‐Deoxy Sugar or 1,5‐Anhydro‐itols.
Authors: Bruyere Isabelle , Toth Zoltan , Benyahia Hamida , Xue Jia Lu , Praly Jean‐Pierre 
Published: February 2014

AbstractThe access to the title compounds depends on the leak or the presence of thiophenol.
ChemInform Abstract: Bi‐Functional Fluoroalkylation Reagents: An Introduction to Halo‐Substituted 3‐Oxa‐perfluoroalkanesulfonyl Fluorides
Authors: Zhang Cheng‐Pan , Chen Qing‐Yun , Guo Yong , Xiao Ji‐Chang 
Published: February 2014

AbstractReview: synthesis, reactivity, and applications; <100 refs.
Anion Effect on the Binary and Ternary Phase Diagrams of Chiral Medetomidine Salts and Conglomerate Crystal Formation
Authors: Choobdari Ebrahim , Fakhraian Hossein , Peyrovi Mohammad Hassan 
Published: February 2014

ABSTRACTThe binary phase diagrams of hydrogen halides salts of medetomidine (Med.HX, X:Br,I) and hydrogen oxalate salt of medetomidine (Med.Ox) were determined based on thermogravimetric/differential thermal analysis (TGA/DTA) and their crystal structure behavior was confirmed by comparison of the X‐ray diffractometry and FT‐IR spectroscopy of the racemate and pure enantiomer. All hydrogen halide salts presented racemic compound behavior. Heat of fusion of halides salt of (rac)‐medetomidine decreased with ionic radius increase. Eutectic points for Med.HCl (previously reported), Med.HBr, and Med.HI rest were unchanged approximately. The solubility of different enantiomeric mixtures of Med.HBr and Med.HI were measured at 10, 20, and 30°C in 2‐propanol showing a solubility increase with ionic radius. A binary phase diagram of Med.Ox shows a racemic conglomerate behavior. The solubility of enantiomeric mixtures of Med.Ox were measured at 10, 20, 30, and 40°C. The ternary phase diagram of Med.Ox in ethanol conforms to a conglomerate crystal forming system, favoring its enantiomeric purification by preferential crystallization. Chirality 26:183–188, 2014. © 2014 Wiley Periodicals, Inc.
Patient and Therapist Perspectives on Alliance Development: Therapists' Practice Experiences as Predictors
Authors: Nissen‐Lie Helene A. , Havik Odd E. , Høglend Per A. , Rønnestad Michael Helge , Monsen Jon T. 
Published: February 2014

Research has shown that the therapist's contribution to the alliance is more important for the outcome than the patient's contribution (e.g., Baldwin, Wampold, & Imel, 2007); however, knowledge is lacking about which therapist characteristics are relevant for alliance building and development. The objective of this study was to explore the development of the working alliance (using the Working Alliance Inventory), rated by both patients and therapists as a function of therapist in‐session experiences. The therapist experiences were gathered by means of the Development of Psychotherapists Common Core Questionnaire (Orlinsky & Rønnestad, 2005). Data from the Norwegian Multisite Study of the Process and Outcome of Psychotherapy (Havik et al., 1995) were used. Multilevel growth curve analyses of alliance scores from Sessions 3, 12, 20 and 40 showed that the therapist factors predicted working alliance levels or growths differently, depending on whether the alliance was rated by patients or by therapists. For example, it emerged that therapists' negative reactions to patients and their in‐session anxiety affected patient‐rated alliance but not therapist‐rated alliance, whereas therapist experiences of flow (Csikszentmihalyi, 1990) during sessions impacted only the therapist‐rated alliance. The patterns observed in this study imply that therapists should be particularly aware that their negative experiences of therapy are noticed by, and seem to influence, their clients when they evaluate the working alliance through the course of treatment. Copyright © 2014 John Wiley & Sons, Ltd.Key Practitioner Message
The findings of this study suggest that the working alliance is influenced by therapists' self‐reported practice experiences, which presumably are communicated through the therapists' in‐session behaviours.
The study found a notable divergence between practice experiences that influenced the therapists and those that influenced the patients when evaluating the working alliance.
Specifically, practitioners' self‐reported difficulties in practice, such as their negative reactions to patients and their in‐session anxiety, affected patient‐rated alliance but not therapist‐rated alliance, whereas therapist experiences of ‘flow’ during sessions impacted only the therapist‐rated alliance.
Practitioners should note that patient alliance ratings were more likely to be influenced by therapists' negative practice experiences than by positive ones.
The divergence in the patient and therapist viewpoints has potential implications for therapist training and supervision and everyday self‐reflection.
Propylene from Renewable Resources: Catalytic Conversion of Glycerol into Propylene
Authors: Yu Lei , Yuan Jing , Zhang Qi , Liu Yong‐Mei , He He‐Yong , Fan Kang‐Nian , Cao Yong 
Published: February 2014

AbstractPropylene, one of the most demanded commodity chemicals, is obtained overwhelmingly from fossil resources. In view of the diminishing fossil resources and the ongoing climate change, the identification of new efficient and alternative routes for the large‐scale production of propylene from biorenewable resources has become essential. Herein, a new selective route for the synthesis of propylene from bio‐derived glycerol is demonstrated. The route consists of the formation of 1‐propanol (a versatile bulk chemical) as intermediate through hydrogenolysis of glycerol at a high selectivity. A subsequent dehydration produces propylene.
Temperature‐ and Humidity‐Controlled SAXS Analysis of Proton‐Conductive Ionomer Membranes for Fuel Cells
Authors: Mochizuki Takashi , Kakinuma Katsuyoshi , Uchida Makoto , Deki Shigehito , Watanabe Masahiro , Miyatake Kenji 
Published: February 2014

AbstractWe report herein temperature‐ and humidity‐controlled small‐angle X‐ray scattering (SAXS) analyses of proton‐conductive ionomer membranes. The morphological changes of perfluorosulfonic acid polymers (Nafion and Aquivion) and sulfonated aromatic block copolymers (SPE‐bl‐1 and SPK‐bl‐1) were investigated and compared under conditions relevant to fuel cell operation. For the perfluorinated ionomer membranes, water molecules were preferentially incorporated into ionic clusters, resulting in phase separation and formation of ion channels. In contrast, for the aromatic ionomer membranes, wetting led to randomization of the ionic clusters. The results describe the differences in the proton‐conducting behavior between the fluorinated and nonfluorinated ionomer membranes, and their dependence on the humidity.
Improved IPSec tunnel establishment for 3GPP–WLAN interworking
Authors: Samoui S. , El Bouabidi I. , Obaidat M. S. , Zarai F. , Hsiao K. F. , Kamoun L. 
Published: February 2014

SummaryInterworking between wireless local area network (WLAN) and the 3rd Generation Partnership Project (3GPP) such as Long Term Evolution (LTE) is facing more and more problems linked to security threats. Securing this interworking is a major challenge because of the vastly different architectures used within each network. Therefore, security is one of the major technical concerns in wireless networks that include measures such as authentication and encryption. Among the major challenges in the interworking security is the securing of the network layer. The goal of this article is twofold. First, we propose a new scheme to secure 3GPP LTE–WLAN interworking by the establishment of an improved IP Security tunnel between them. The proposed solution combines the Internet Key Exchange (IKEv2) with the Host Identity Protocol (HIP) to set up a security association based on two parameters, which are location and identity. Our novel scheme, which is called HIP_IKEv2, guarantees better security properties than each protocol used alone. Second, we benefit from Mobile Internet Key Exchange protocol (MOBIKE) in case of mobility events (handover). And we extend HIP_IKEv2 to HIP_MOBIKEv2 protocol in order to reduce the authentication signaling traffic. The proposed solution reinforces authentication, eliminates man‐in‐the‐middle attack, reduces denial‐of‐service attack, assures the integrity of messages, and secures against reply attack. Finally, our proposed solution has been modeled and verified using the Automated Validation of Internet Security Protocols and Applications and the Security Protocol Animator, which has proved its security when an intruder is present. Copyright © 2014 John Wiley & Sons, Ltd.
General and food‐specific inhibitory deficits in binge eating disorder
Authors: Svaldi Jennifer , Naumann Eva , Trentowska Monika , Schmitz Florian 
Published: February 2014

ABSTRACTObjectiveTo investigate behavioral inhibition in individuals with binge eating disorder (BED) compared with overweight and obese individuals without BED (No‐BED).MethodParticipants with BED (n = 31) and the weight‐matched No‐BED group (n = 29) completed an inhibitory control task (stop‐signal task, SST) with food and neutral stimuli.ResultsThe BED group needed more time to stop an ongoing response, as indicated by increased stop signal reaction time (SSRT) relative to the No‐BED group. Additionally, compared with the No‐BED group, the BED group displayed more difficulty inhibiting responses elicited by food stimuli. The deficits in behavioral response inhibition were also found to be related to the severity of reported symptoms.DiscussionThere is a general deficit in late stage behavioral inhibition in BED, and this may be particularly pronounced in the context of food stimuli. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:534–542)