bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topological weak-measurement-induced geometric phases revisited
Authors: Puentes Graciana 
Published: June 2024

Abstract

We present an analytic and numerica study of a class of geometric phase induced by weak measurements. In particular, we analyze the dependence of the geometric phase on the winding W of the polar angle φ, upon a sequence of N weak measurements of increased magnitude (c), resulting in the appearance of a multiplicity of critical measurement-strength parameters where the geometric phase becomes stochastic. Adding to the novelty of our approach, we not only analyze the weak-measurement-induced geometric phase by a full analytic derivation, valid in the quasi-continuous limit (N → ∞), but also we analyze the induced geometric phase numerically, thus enabling us to unravel the finite-N interplay of the geometric phase with the measurement strength parameter, and its stability to perturbations in the measurements protocol.
Plant communities under different land uses along an elevational gradient
Authors: Miguel M. Florencia 
Published: June 2024

Abstract

Species richness and composition in plant communities change with altitude. Currently, species are facing challenges caused by several drivers of global changes, such as climate change and land use change, which may alter their distribution patterns. Novel ecosystems imposed by anthropogenic activities pose new contexts for evaluating classic ecological hypotheses. In this study, I evaluated the distributional patterns of plant species along an elevational gradient in sites under different land uses in a dry mountainous region. Specifically, I registered species richness and composition of plant communities. Total number of plant species significantly varied among altitudes, registering a peak at mid-elevations. Exotic and native species registered a peak at mid-elevations and cultivated species decreased with altitude. Moreover, the number of species grouped per growth form varied with altitude depending on the growth form considered. As expected, plant species distribution followed a humped pattern in the dry mountainous region studied, and land usesimpacted on the composition of plant communities. In this context, private lands offer an excellent opportunity for developing conservation projects. I recommend the maintenance of areas with native vegetation and the designing of home gardens using native plants that may ensure the conservation of biodiversity and the associated ecological processes in anthropic modified landscapes.
Analyzing MHD Williamson fluid over a porous stretching sheet with heat and mass transfer by applying Chebyshev Wavelet operational matrix method
Authors: S Prithvi , R Vidya Shree , B Patil Mallikarjun 
Published: June 2024

Abstract

This study investigates the boundary layer Williamson fluid flow as well as heat transfer triggered by a nonlinearly expanding sheet. The fluid flow of liquid films has been reported to be two-dimensional. A suitable approach has been set up to solve the modeled problem. Chebyshev wavelet operational matrix method is newly devised method for transforming the non linear differential equations to nonlinear algebraic equations. This computation is flexible and facile due to the generation of integral matrices. From these integral matrices unresolved Chebyshev wavelet coefficients are determined with the help of newton raphson method. Thus solution to the given Williamson fluid flow is achieved. The convergence of the approach is currently demonstrated through computation. The non dimensional physical quantities are estimated by employing Chebyshev wavelet method which is effectively executed as a novel study. These findings are validated with previous data thus demonstrating perfect synchrony in the physical parameters. These novel procedures have the potential to boost research and technology for future generations.
Real-World Super-Resolution Based on Iterative Frequency Domain Degradation Model
Authors: Hao Yukun , Liu Yuchen 
Published: June 2024

Abstract

Single-image super-resolution (SR) methods often encounter difficulties when applied to real-worldimages because of deviations between the degradation model and real-world degradation distribution. Recent studies have attempted to address this issue by adopting more complex degradation models tosimulate real-world degradation distributions. However, these methods tend to produce over-smoothedresults lacking fine-grained details. Furthermore, these methods neglect the disparity between syntheticand real-world images in the frequency domain. This study proposes a more practical and detail-oriented degradation model for real-world image SR. The proposed model employs aliasing estimationand an iterative frequency domain degradation algorithm to narrow the frequency domain gap between synthetic and real-world images, thus expanding the latent degradation distribution. The proposedmodel considers the impact of various factors such as camera shake, defocus, and compression onthe image, effectively simulating the complex and diverse degradation processes in the real world.Experiments demonstrate that combining the proposed degradation model with existing SR methods achieves excellent image perceptual quality on real-world images.
Novel Oncolytic Virus VG161 in Hepatocellular Carcinoma Patients Refractory to Standard Systemic Therapies
Authors: Liang Tingbo , Shen Yinan , Bai Xueli , Zhang Qi , Liang Xingmei , Jin Xinyan , Zhao Zeda , Song Wei , Tan Qian , Zhao Ronghua , Jia William , Gu Shanzhi , Shi Guoming , Zheng Ziwei , Wei Guyue , Wang Youlei , Fang Tian , Li Yuwei , Wang Zijun , Yang Zifan , Guo Sida , Lin Danni , Wei Fang , Wang Lei , Sun Xiaoli , Qin Aijun , Xie Longshen , Qiu Yeting , Bao Wenqing , Rahimian Shah , Singh Manu , Murad Yanal , Shang Jianying , Chu Min , Huang Maoliang , Ding Jun , Chen Wei , Ye Yufu , Chen Yiwen , Li Xiang 
Published: June 2024

Abstract

For hepatocellular carcinoma (HCC) patients, treatment options are limited after failing second-line therapy. This phase I, multicenter trial evaluates the safety and antitumor efficacy of VG161 in patients with advanced liver cancer. The study included dose escalation using a ‘3 + 3’ design across five dose levels, followed by a dose expansion phase using Simon’s two-stage design. Forty-four patients received doses with no dose-limiting toxicity observed. Among the 40 HCC patients, 37 were evaluable. The objective response rate (ORR) was 18.92%, and the disease control rate (DCR) was 64.86%. The median progression-free survival (PFS) was 2.9 months, and overall survival (OS) was 12.4 months. Subgroup analysis showed that among 34 patients who had failed second-line treatment, the ORR was 17.65% and the DCR was 64.71%. The median PFS and OS for this group were 2.8 and 9.4 months, respectively. Patients with prior checkpoint inhibitor treatment (PreCPI) longer than 3 months had a median OS of 17.3 months, compared to 7.4 months for those with PreCPI ≤ 3 m (p = 0.04). Additionally, patients receiving systemic therapies after VG161 showed longer survival (p = 0.03). Multiple detection techniques revealed that VG161 reshapes the immune microenvironment of HCC, enhancing tumor sensitivity to systemic treatments. An efficacy prediction model based on differentially expressed genes was established, which successfully predicts prolonged OS in study patients (p < 0.001) but not in public database patients (p = 0.17). Anti-hepatitis B agents were confirmed to not affect the replication and efficacy of VG161. In summary, VG161 demonstrated comparable efficacy to second-line treatments in third-line patients, providing a new option for patients who have failed second-line therapy. It was well-tolerated and showed promising efficacy, extending survival in some subgroups and enhancing post-treatment systemic therapy efficacy, supporting its potential use in combination treatments. ClinicalTrials.gov registration: NCT04806464.
Vulgar Remarks Detection in Chittagonian Dialect of Bangla
Authors: Mahmud Tanjim , Ptaszynski Michal , Masui Fumito 
Published: June 2024

Abstract

The negative effects of online bullying and harassment are increasing with Internet popularity, especially in social media. One solution is using natural language processing (NLP) and machine learning (ML) methods for the automatic detection of harmful remarks, but these methods are limited in low-resource languages like the Chittagonian dialect of Bangla. This study focuses on detecting vulgar remarks in social media using supervised ML and deep learning algorithms. Logistic Regression achieved promising accuracy (0.91) while simple RNN with Word2vec and fastTex had lower accuracy (0.84-0.90), highlighting the issue that NN algorithms require more data.
Complications &amp; Recurrence Of Bariatric Surgery
Authors: Bouzo Maher , Ghanem Muhmmad , Skaf MHD Jawad , affone Moaead , Alsous Mohamad Haidar 
Published: June 2024

Abstract

Objective
To compare longitudinal gastric bypass and mini-gastric bypass in terms of the ability to lose excess weight and cure associated morbidity (diabetes, hypertension, joint pain).
Methods and materials
All obese patients who met the admission criteria for the previously mentioned study and who attended Damascus University Hospitals (Al-Assad University Hospital - Al-Mowasat University Hospital - Al-Mujtahid Hospital) and who underwent surgery were studied, provided that the sample size was not less than 100 patients.
Results
Our study included 100 patients (78 underwent longitudinal resection and 22 underwent mini-gastric bypass). The average age was 37 years for longitudinal resection and 39 years for mini-gastric bypass. The majority of patients were female, 76.92% in the longitudinal resection group and 72.73% in the mini-gastric bypass group. The importance of bariatric surgery has emerged in treating diseases associated with obesity, such as diabetes and high blood pressure. The rates of improvement or recovery were almost the same in diabetes (78.26%) after the longitudinal section, compared to (83.33%) in the mini-gastric bypass and in high blood pressure (76.92). %) for longitudinal resection compared to (90%) for mini gastric bypass.
Conclusion
from the above, we see that longitudinal resection and gastric bypass have similar results in terms of losing excess weight and healing or improving associated morbidity.
Incidência de ataque de serrasalmus spp. após alterações ambientais em rios: relato de caso na praia de filadélfia – Tocantins
Authors: Soares Pedro , PERETTI Danielle , Dantas de oliveira Jean Carlos , Oliveira Jonnata Fernandes de , Torres de Medeiros Marcelo Henrique , Gomes Dantas Marcus Vinicius 
Published: June 2024

O estudo investigou a incidência de ataques de Serrasalmus spp na Praia de Filadélfia, Tocantins, correlacionando-a a fatores ambientais e comportamentais. Durante a alta estação, observou-se um aumento significativo nos ataques, destacando a urgência de medidas preventivas. A diferença temporal entre a desova e os ataques sugere impactos ambientais, especialmente devido à formação de reservatórios da Usina Hidroelétrica de Estreito (UHE). Propostas estratégicas incluem educação ambiental e campanhas direcionadas, inspiradas em casos bem-sucedidos. Monitoramento, manutenção dos ecossistemas e fiscalização são ferramentas cruciais para antecipar padrões comportamentais das piranhas. O incentivo à pesquisa contínua permite ajustar estratégias ao longo do tempo, garantindo uma abordagem adaptativa. A colaboração entre autoridades locais, comunidades e pesquisadores é imperativa para implementar medidas, visando a redução dos ataques e a preservação sustentável do ecossistema aquático. O estudo enfatiza a busca por um equilíbrio harmonioso entre o turismo e a conservação ambiental na Praia de Filadélfia.

Palavras-chave: Ataque; Educação ambiental; sazonalidade.
Monoclonal Antibodies: Current Advancements and Future Potential for
Atopic Dermatitis Therapy
Authors: Kumar Pravin , Ashawat Mahendra Singh , Kumar Ajay , Guleria Anchal , Thakur Akshay 
Published: June 2024

Background:
Atopic Dermatitis (AD) is an inflammatory skin condition with a severe itch. The topical therapy using corticosteroids is not sufficient for the effective therapy of
moderate to severe cases of AD. The investigation and development of immunological targetspecific human monoclonal antibodies have changed the paradigm for the therapy of moderate
to severe cases of AD.

Objective:
The establishment of target-specific, tolerable, and efficacious human monoclonal
antibodies might lead to the better management of moderate to severe cases of AD.

Methodology:
The scientific literature available in databases, such as Pubmed and Clinicaltrial.gov, was searched and discussed for available clinical therapeutic information.

Discussion:
The present review has discussed the potential immunological targets of specific
monoclonal antibodies developed and approved or which are under investigation in clinical trials.

Conclusion:
The development of targeted monoclonal antibodies can improve the understanding
of the role of different immunological pathways and biomarkers in AD and become the future of
AD treatment.
Exploring Marine Alkaloids: A Natural Approach to Cancer Treatment
Authors: Singh Sonia , Kumar Surendra , Singh Amit Kumar , Varshney Mayuri , Roy Suchismita 
Published: June 2024

:
Cancer is one of the most complicated and prevalent diseases in the world, and its
incidence is growing worldwide. Natural products containing pharmacological activity are widely
used in the pharmaceutical industry, especially in anticancer drugs, due to their diverse structures
and distinctive functional groups that inspire new drug results by means of synthetic chemistry.
Terrestrial medicinal plants have traditionally been the primary source for developing natural
products (NPs). However, over the past thirty years, marine organisms such as invertebrates,
plants, algae, and bacteria have revealed many new pharmaceutical compounds known as
marine NPs. This field constantly evolves as a discipline in molecular targeted drug discovery,
incorporating advanced screening tools that have revolutionised and become integral to modern
antitumor research. This review discusses recent studies on new natural anticancer alkaloids
obtained from marine organisms. The paper illustrates the structure and origin of marine alkaloids
and demonstrates the cytotoxic action of new alkaloids from several structural families and
their synthetic analogs. The most recent findings about the potential or development of some of
them as novel medications, together with the status of our understanding of their current mechanisms
of action, are also compiled.
Activation of Src Kinase Mediates the Disruption of Adherens Junction in the Blood-labyrinth Barrier after Acoustic Trauma
Authors: Sun Jianbin , Zhang Tong , Tang Chaoying , Fan Shuhang , Wang Qin , Liu Da , Sai Na , Ji Qi , Guo Weiwei , Han Weiju 
Published: June 2024

Background:
Adherens junction in the blood-labyrinth barrier is largely unexplored because
it is traditionally thought to be less important than the tight junction. Since increasing evidence
indicates that it actually functions upstream of tight junction adherens junction may potentially
be a better target for ameliorating the leakage of the blood-labyrinth barrier under pathological
conditions such as acoustic trauma.

Aims:
This study was conducted to investigate the pathogenesis of the disruption of adherens junction
after acoustic trauma and explore potential therapeutic targets.

Methods:
Critical targets that regulated the disruption of adherens junction were investigated by
techniques such as immunofluorescence and Western blotting in C57BL/6J mice.

Results:
Upregulation of Vascular Endothelial Growth Factor (VEGF) and downregulation of Pigment
Epithelium-derived Factor (PEDF) coactivated VEGF-PEDF/VEGF receptor 2 (VEGFR2)
signaling pathway in the stria vascularis after noise exposure. Downstream effector Src kinase
was then activated to degrade VE-cadherin and dissociate adherens junction, which led to the leakage
of the blood-labyrinth barrier. By inhibiting VEGFR2 or Src kinase, VE-cadherin degradation
and blood-labyrinth barrier leakage could be attenuated, but Src kinase represented a better target
to ameliorate blood-labyrinth barrier leakage as inhibiting it would not interfere with vascular endothelium
repair, neurotrophy and pericytes proliferation mediated by upstream VEGFR2.

Conclusion:
Src kinase may represent a promising target to relieve noise-induced disruption of adherens
junction and hyperpermeability of the blood-labyrinth barrier.
Insulin Abuse: A Case Report of Munchausen Syndrome
Authors: Basaran Elif , Tastekin Nihal , Aytekin Yunus Emre , Aktas Gulali 
Published: June 2024

:
Hypoglycaemia in individuals with diabetes is defined as the presence of signs or
symptoms in addition to potentially occurring abnormal plasma glucose levels in the patient.
Munchausen Syndrome (MS) is characterized by the deliberate induction of physical or psychological
symptoms or the act of pretending to have symptoms. Patient reports of this factitious
disease pattern are limited in the literature. The diagnosis and treatment of this syndrome, which
is among factitious disorders, is very difficult. Endocrinological complaints are very common
among those admitted to the hospitals.

Background:
Unnecessary and numerous examinations cause financial losses and loss of time
for both the individual and the healthcare system. In this case report, we aimed to discuss the
management of a patient who tried to gain secondary gain by creating artificial hypoglycemia
attacks.

Case Report:
In this case report, the diagnosis of Munchausen syndrome given to a 28-year-old
female patient who was diagnosed with type I diabetes and repeatedly admitted to the hospital
due to hypoglycemia attacks is discussed.

Conclusion:
Munchausen syndrome is an important and often overlooked diagnosis that should
be kept in mind due to the possibility of individuals harming themselves unpredictably, as well
as causing disruptions in the healthcare system and wasting time due to numerous and
unnecessary examinations and evaluations. For this reason, it is a diagnosis that should be kept
in mind in cases of unexplained hypoglycemia attacks.
Calcitonin-producing Duodenal Neuroendocrine Tumor: A Case Report and Literature Review
Authors: Paz-Ibarra Jose , Suarez-Rojas Jacsel , Alvarez Gamero Julio Cesar , Concepcion-Zavaleta Marcio , Quiroz-Aldave Juan Eduardo , Somocurcio-Peralta Jose 
Published: June 2024

Introduction:
Neuroendocrine tumors (NETs) exhibit a wide range of clinical
presentations, including the production of various hormones. Calcitonin, a sensitive marker for
medullary thyroid cancer (MTC), is nonspecific and may be elevated in extra-thyroidal NETs.

Case Report:
We present the case of a 64-year-old female patient who underwent total
thyroidectomy due to a nodule in the isthmus, with a fine-needle aspiration biopsy indicating
follicular neoplasia. Pathological examination revealed macro- and micro-nodular thyroid hyperplasia,
along with a parathyroid adenoma. During postoperative follow-up, a progressive
elevation of calcitonin was observed, reaching 64.2 pg/ml, while carcinoembryonic antigen levels
remained normal. Since no MTC foci were found upon reviewing the thyroidectomy specimen,
an investigation into the origin of the elevated calcitonin was initiated. Serum chromogranin
A and specific neuronal enolase levels were within normal ranges. Tc-99m HYNICTOC
scintigraphy yielded negative results. Additionally, an upper gastrointestinal endoscopy
revealed a submucosal lesion in the second portion of the duodenum, with a biopsy confirming
a grade 1 NET. The patient underwent Whipple surgery and hepatic metastasectomy. Postoperatively,
a decrease in baseline serum calcitonin levels was observed. Seven years after surgery,
she continues specialized monitoring with no biochemical or imaging evidence of disease.

Conclusion:
Serum calcitonin contributes to the diagnosis and monitoring of anterior intestine
NETs.
Localized Surface Plasmon Resonance (LSPR) of Nanomaterials for
Colorimetric Detection: A Review
Authors: Kant Tushar , Shrivas Kamlesh , Dahariya Nohar Singh 
Published: June 2024

:
Colorimetric sensors are attracting considerable interest across diverse fields owing to their ease of use, cost-effectiveness, and rapidity. Within this
realm, Localized Surface Plasmon Resonance (LSPR) stands out as a favorable method for designing colorimetric sensing techniques. Sensors
based on LSPR control the plasmonic characteristics of metallic Nanoparticles (NPs) to produce a noticeable alteration in color when a target
analyte is detected. This article explores recent advancements in this field, including the integration of LSPR sensors with microfluidics and
smartphone-based detection systems. The paper also investigates the applications of LSPR-based colorimetric sensors in diverse domains, such as
environmental monitoring, biomedical diagnostics, food safety, and chemical detection. Furthermore, it sheds light on the potential limitations and
prospects associated with LSPR-based colorimetric sensors, with a particular emphasis on the need for improved sensitivity, selectivity, and
stability to facilitate broader practical applications.
Applications of Baker-venkataraman Rearrangement in the Synthesis of
Promising Organic Molecules
Authors: Majhi Sasadhar 
Published: June 2024

:
In organic synthesis, carbon-carbon bond formation is the fundamental transformation to create the carbon backbone of organic molecules and this
key reaction is very popular in the improvement of organic chemistry, which exists at the bottom of the heart of the chemical sciences. The Baker-
Venkataraman rearrangement has received great attention in the formation of 1,3-diketones through the regioselective construction of carboncarbon
bonds. This rearrangement is an important type of chemical transformation in which the intramolecular migration of the ester acyl group
takes place to provide 1,3-diketones in the presence of the base. Generally, 1,3-diketones or ortho-hydroxydibenzoylmethane derivatives undergo
cyclization to provide the corresponding flavones in the presence of concentrated sulfuric acid. The Baker-Venkataraman rearrangement is
frequently employed in the preparation of flavones and chromones. Besides, anthrapyran and anthracyclin antibiotics, benzopyrans, coumarins,
xanthones, etc., are also synthesized with the help of these reactions. This review deals with the brilliant application of the Baker-Venkataraman
rearrangement in the synthesis of promising organic compounds.