bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of objective and subjective types of binge eating episodes in a clinical sample of people with co-morbid obesity
Authors: Palavras Marly Amorim , Morgan Christina Marcondes , Borges Ferrari Maria Beatriz , Claudino Angélica Medeiros , Hay Phillipa J 
Published: July 2013

Abstract

Background
Objective binge eating episodes (OBEs) refer to binge eating on an unusually large amount of food and are the core symptom in current definitions of bulimia nervosa (BN) and binge eating disorder (BED). Subjective binge eating episodes (SBEs) refer to eating on a small or moderate amount of food (that is perceived as large) and like OBEs are associated with loss of control (LOC). Reaching consensus on what is considered a large amount of food can however be problematic and it remains unclear if the size of a binge is an essential component for defining a binge eating episode. The aim of this study was to compare the eating disorder features and general psychopathology of subjects reporting OBEs with those reporting only SBEs.

Methods
This is a retrospective secondary analysis of data from 70 obese participants at the recruitment phase of a multicentre trial for BED. Individuals who answered positively to the presence of binge eating and LOC over eating had their binge eating episodes further explored by interview and self-report. Two groups, those who reported current OBEs (with or without SBEs) and those who reported current SBEs only were compared for age, gender, marital status, body mass index (BMI), indicators of LOC over eating, severity of binge-eating and associated psychopathology.

Results
The majority of participants in both the OBE and SBE groups endorsed the experience of at least four indicators of LOC. There were no significant differences between the groups. Both groups had high levels of binge-eating severity, moderate severity of associated depressive symptoms and frequent psychiatric co-morbidity.

Conclusion
Treatment seeking participants with obesity who reported SBEs alone were similar to those who reported OBEs in terms of eating disorder features and general psychopathology. These findings suggest that classificatory systems of mental illnesses should consider introducing SBEs as a feature of the diagnostic criteria for binge eating and, thus, facilitate the inclusion of participants with SBEs in treatment trials.
Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer
Authors: Bhatta Sumita S , Hou Ningqi , Moton Zakiya N , Polite Blase N , Fleming Gini F , Olopade Olufunmilayo I , Huo Dezheng , Hong Susan 
Published: July 2013

Abstract

Background
Studies have demonstrated lower rates of breast cancer survival for Black versus White women. Factors implicated include later stages at diagnosis, differences in tumor biology, and lower compliance rates to adjuvant hormone therapy (AHT) among Black women with hormone sensitive breast cancer. We examined factors associated with compliance to AHT among Black and White women with invasive breast cancer.

Methods
Women with estrogen receptor positive (ER+), non-metastatic breast cancer were identified by the cancer registry at the University of Chicago Hospital and asked to complete a mail-in survey. Compliance was defined by self-reported adherence to AHT ≥80% at the time of the survey plus medical record verification of persistence (completion of 5 years of AHT). Logistic regression was used to determine factors associated with compliance to AHT.

Results
197 (135 White and 62 Black) women were included in the analysis. 97.4% of patients reported adherence to therapy. 87.4% were found to be persistent to therapy. Overall compliance was 87.7% with no statistically significant racial difference seen (87.9% in White and 87.0% in Black, P = 0.87). For both Black and White women, compliance was strongly associated with both perceived importance of AHT (OR =2.1, 95% CI:1.21-3.68, P = 0.009) and the value placed on their doctor’s opinion about the importance of AHT (OR = 4.80, 95% CI: 2.03-11.4, P < 0.001).

Conclusions
In our cohort of Black and White women, perceived importance of AHT and the degree to which they valued their doctor’s opinion correlated with overall compliance. This suggests that Black and White women consider similar factors in their decision to take AHT.
Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study
Authors: Ulla Marco , Pizzolato Elisa , Lucchiari Manuela , Loiacono Maria , Soardo Flavia , Forno Daniela , Morello Fulvio , Lupia Enrico , Moiraghi Corrado , Mengozzi Giulio , Battista Stefania 
Published: July 2013

Abstract
Introduction
Sepsis, severe sepsis and septic shock are common conditions with high mortality. Their early diagnosis in the Emergency Department (ED) is one of the keys to improving survival. Procalcitonin (PCT) has been used as a biomarker in septic patients but has limited specificity and can be elevated in other scenarios of systemic inflammatory response syndrome (SIRS). Soluble CD14 (sCD14) or presepsin is the free fragment of a glycoprotein expressed on monocytes and macrophages. Preliminary reports suggest that levels of presepsin are significantly higher in septic patients than in healthy individuals. The aim of this study is to investigate the diagnostic and prognostic value of presepsin compared to PCT in people presenting at the ED with SIRS and suspected sepsis or septic shock.

Methods
This study was conducted in two major hospitals in Turin, Italy. One hundred six patients presenting to the EDs with suspected sepsis or septic shock were included, and another eighty-three patients affected by SIRS, but with no clinical evidence of infection, were recruited as controls. Blood samples were collected at first medical evaluation and for some patients after 24 and 72 h. The samples were analyzed using the PATHFAST Presepsin assay for sCD14, and commercial kits were used for other determinations (for example, PCT). Definitive diagnosis and survival rates were obtained afterward by analysis of digital medical records.

Results
Elevated concentrations of presepsin at presentation were observed in septic patients compared to control patients. The same trend was observed for mean values of PCT. Higher values of presepsin were observed in septic patients at presentation (time 0). The diagnostic accuracy of PCT was generally higher, and areas under the curve (AUCs) were 0.875 for PCT and 0.701 for presepsin. Mean presepsin values were significantly higher in nonsurvivor septic patients (60-day mortality) than in survivors. No significant correlation was noted between PCT and survival.

Conclusions
In our experience, presepsin was useful in the early diagnosis of infection in a complex population of patients with SIRS, sepsis, severe sepsis and septic shock who presented to the ED. Presepsin showed a significant prognostic value, and initial values were significantly correlated with in-hospital mortality of patients affected by sepsis, severe sepsis or septic shock.
Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice
Authors: Kyrmizi Irene , Ioannou Marianna , Hatziapostolou Maria , Tsichlis Philip N , Boumpas Dimitrios T , Tassiulas Ioannis 
Published: July 2013

ABSTRACTThe MAPK3 Tpl2 controls innate and adaptive immunity by regulating TLR, TNF-α, and GPCR signaling in a variety of cell types. Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS-induced endotoxin shock, DSS-induced colitis, and TNF-α-induced IBD. Here, we address the role of Tpl2 in autoimmunity. Our data show that the ablation and the pharmacological inhibition of Tpl2 protect mice from antiplatelet antibody-induced thrombocytopenia, a model of ITP. Thrombocytopenia in this model and in ITP is caused by phagocytosis of platelets opsonized with antiplatelet antibodies and depends on FcγR activation in splenic and hepatic myeloid cells. Further studies explained how Tpl2 inhibition protects from antibody-induced thrombocytopenia, by showing that Tpl2 is activated by FcγR signals in macrophages and that its activation by these signals is required for ERK activation, cytoplasmic Ca2+ influx, the induction of cytokine and coreceptor gene expression, and phagocytosis.
Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression
Authors: Speranza Francis J , Mahankali Madhu , Gomez-Cambronero Julian 
Published: July 2013

ABSTRACTMonocytes and neutrophils infiltrate into tissues during inflammation and stay for extended periods of time until the initial insult is resolved or sometimes remain even longer in the case of chronic inflammation. The mechanism as to why phagocytes become immobilized after the initial cell migration event is not understood completely. Here, we show that overexpression or hyperactivation of Rac2 decreases sustained chemotactic responses of macrophages to MCP-1/CCL2. The resulting leukocyte arrest is not caused by a diminished availability of the cytokine receptor CCR2 that remains intact during MCP-1 stimulation. We show a novel mechanism that links the Rac2-dependent arrest of chemotaxis to decreased expression of PLD2 through the transcription regulator Sp1. Prolonged Rac2 activity leads to nuclear overactivation of Sp1, which acts as a repressor for PLD2. Also, another signaling component plays a regulatory role: β-catenin. Although early times of stimulation (∼20 min) with MCP-1/CCL2 resulted in activation of β-catenin with a positive effect on PLD2, after ∼3 h of stimulation, the levels of β-catenin were reduced and not able to prevent the negative effect of Rac2 on PLD2 activity. This is a novel molecular mechanism underlying immobilization of monocyte/macrophage migration that is important for the physiological maintenance of leukocytes at the site of inflammation. If this immobilization is prolonged enough, it could lead to chronic inflammation.
Randomized Controlled Trial of a Structured Intervention to Facilitate End-of-Life Decision Making in Patients With Advanced Cancer
Authors: Stein Rhea A. , Sharpe Louise , Bell Melanie L. , Boyle Fran M. , Dunn Stewart M. , Clarke Stephen J. 
Published: July 2013

Purpose This study tested the efficacy of an intervention on end-of-life decision making for patients with advanced cancer. Patients and Methods One hundred twenty patients with metastatic cancer who were no longer being treated with curative intent (and 87 caregivers) were randomly assigned to the intervention (n = 55) or treatment as usual (n = 65). Primary outcome measures were the proportion of patients with do-not-resuscitate (DNR) orders, timing of DNR orders, and place of death. Secondary outcome measures were completed at study enrollment, 3 weeks later, and 3 months later, including patients' knowledge, mood, and caregiver burden. Results High, but equivalent, rates of DNR orders were observed in both groups. In per-protocol analyses, DNR orders were placed earlier for patients who received the intervention (median, 27 v 12.5 days; 95% CI, 1.1 to 5.9; P = .03) and they were more likely to avoid a hospital death (19% v 50% (95% CI, 11% to 50%; P = .004). Differences between the groups over time were evident for estimates of cardiopulmonary rehabilitation (CPR) success rates (P = .01) but not knowledge of CPR (P = .2). There was no evidence that the intervention resulted in more anxious or depressive symptoms. Caregivers experienced less burden in terms of disruption to schedule if the patient received the intervention (P = .05). Conclusion An intervention, consisting of an informational pamphlet and discussion, was associated with earlier placement of DNR orders relative to death and less likelihood of death in hospital. There was no negative impact of the intervention on secondary outcomes, although the sample may have been too small to detect differences.
Patterns of Recurrence and Outcome According to Breast Cancer Subtypes in Lymph Node–Negative Disease: Results From International Breast Cancer Study Group Trials VIII and IX
Authors: Metzger-Filho Otto , Sun Zhuoxin , Viale Giuseppe , Price Karen N. , Crivellari Diana , Snyder Raymond D. , Gelber Richard D. , Castiglione-Gertsch Monica , Coates Alan S. , Goldhirsch Aron , Cardoso Fatima 
Published: July 2013

Purpose To retrospectively evaluate the pattern of recurrence and outcome of node-negative breast cancer (BC) according to major subtypes. Patients and Methods In all, 1,951 patients with node-negative, early-stage BC randomly assigned in International Breast Cancer Study Group Trials VIII and IX with centrally reviewed pathology data were included. BC subtypes were defined as triple negative (TN; n = 310), human epidermal growth factor receptor 2 (HER2) positive (n = 369), and hormone receptor positive with high (luminal B–like [LB-like]; n = 763) or low (luminal A–like [LA-like]; n = 509) proliferative activity by Ki-67 labeling index. BC-free interval (BCFI) events were invasive BC recurrence in local, contralateral breast, nodal, bone, or visceral sites. Time to first site–specific recurrence was evaluated by using cumulative incidence and competing risks regression analysis. Results Median follow-up was 12.5 years. The 10-year BCFI was higher for patients with LA-like (86%) BC compared with LB-like (76%), HER2 (73%), and TN (71%; P < .001) BC. TN and HER2 cohorts had higher hazard of BCFI event in the first 4 years after diagnosis (pre-trastuzumab). LB-like cohorts had a continuously higher hazard of BCFI event over time compared with LA-like cohorts. Ten-year overall survival was higher for LA-like (89%) compared with LB-like (83%), HER2 (77%), and TN (75%; P < .001) BC. LB-like subtypes had higher rates of bone as first recurrence site than other subtypes (P = .005). Visceral recurrence as first site was lower for the LA-like subgroup, with similar incidence among the other subgroups when treated with chemotherapy (P = .003). Conclusion BC subtypes have different distant recurrence patterns over time. Defining different patterns of BC recurrence can improve BC care through surveillance guidelines and can guide the design of clinical studies.
The role of resiliency in the process of adaptation to life after heart transplantation
Authors: Baran Agnieszka 
Published: July 2013

Aim of the studyThe aim of the research was to find out if resiliency is a potentially significant factor in the process of adaptation after heart transplantation.Subject or material and methodsThe research included 53 people after heart transplantation, hospitalized in the John Paul II Hospital in Krakow. Measures included a self-made interview questionnaire; the Acceptance of Illness Scale, the Polish Resiliency Assessment Scale SPP-25. The necessary statistics were conducted by means of SPSS program.ResultsExamined group of heart transplant patients appeared to be well adapted to living with a transplanted heart and was characterized by an average level of resiliency. The results supported the hypotheses regarding the relationship between resiliency and adaptation after heart transplantation. A special role in the process of adapting to life with new heart seems to play a personal skills to cope, tolerate negative emotions and failures, and the ability to view life as a challenge.Discussion.ConclusionsResiliency is a factor significantly related to adaptation after heart transplantation, and it has implications for clinical practice, especially for the rehabilitation of patients after transplantation. It seems to be important to shape and develop these elements of resiliency which are mostly related to positive adaptation after heart transplantation.
Journalism, climate science and the public: Towards better practices
Authors: McIlwaine Steve 
Published: July 2013

Abstract
Media reporting and analysis of climate-change science is a fundamental and vital requirement for public understanding and engagement in the increasingly serious issue of global climate change. However, journalists have largely failed to come to grips with the science and its practitioners: they have generally failed to obtain an adequate understanding of what the science is about, they have used inappropriate reporting and framing techniques and have been unduly influenced by vested interests. The result is that media audiences have been left confused, apathetic and even hostile about climate-change news. This article analyses the major shortcomings in media reporting of climate-change science and proposes means by which journalists can, without great difficulty, better serve their audiences, their organizations and themselves in this area of major professional importance.
Public engagement with climate change: What do we know and where do we go from here?
Authors: Whitmarsh Lorraine , O’Neill Saffron , Lorenzoni Irene 
Published: July 2013

Abstract
Climate change is an issue with fundamental implications for societies and individuals. These implications range from our everyday choices about resource use and lifestyles, through how we adjust to an unprecedented rate of environmental change, to our role in debating and enacting accompanying social transitions. This article outlines the various ways in which members of society (‘publics’) may be engaged in efforts to mitigate and adapt to climate change, and then provides a synthesis of lessons about public engagement which span both theoretical and practical insights. These include the diverse drivers of, and barriers to, engagement; the importance of multiple forms of engagement and messages; and a critical need to evaluate and identify successful examples of engagement. We conclude by outlining priorities for future research, policy and practice.
Towards an Ethics of Intimate Audience
Authors: Iball Helen 
Published: July 2013

Abstract
As so-called ‘intimate theatre’ (Gardner 2009) becomes a feature of UK festivals such as the Edinburgh Fringe and the focus of the BAC (Battersea Arts Centre, London) One-on-One Festival (2010 and 2011), so relations between audience and performer alter. This shift has raised concerns about the ethics of theatre audience participation. Taking Adrian Howells’s one-to-one performance Footwashing for the Sole (premiered Glasgow 2009, international touring since 2009) as its case study, the article undertakes an ethical review that identifies key benefits and risks of the activity for Howells and his participants. The evidence is drawn from a three-day interdisciplinary research workshop conducted with Howells and student theatre-makers, witnessed by psychologists and applied ethicists (Workshop Theatre, University of Leeds 2010). Using video clips of the two workshop performances of Footwashing for the Sole, which are available to readers via an online archive, the article proposes an ethics of intimate audience that draws upon a key concept from Eve Sedgwick’s Touching Feeling (2003) read through Nel Noddings’s care theory (1984). It concludes that, in a dynamic heightened by the ‘particular intimacy’ (Sedgwick 2003) between physical touch and emotion, Howells and his audience-participant bring their ‘ethical selves’ (Noddings 1984 and 2007) to this ‘accelerated friendship/relationship between two initial strangers’ (Howells 2009).
The Welfare Effects of Location and Quality in Oligopoly
Authors: Corchón Luis Carlos , Zudenkova Galina 
Published: July 2013

Abstract
In this article, we show that in models where location is endogenous, maximum welfare losses arising from non-optimal locations or from the lack of market coverage may be substantial. In contrast, maximum welfare losses arising from non-optimal quality choices are more modest, but they might vary discontinuously with the dispersion in consumer tastes. Very often, welfare losses can be inferred from data.
Measuring the Financial Exposure from Medical Care Spending Among Families with Employer Sponsored Insurance
Authors: Abraham Jean M. , Royalty Anne Beeson , DeLeire Thomas 
Published: July 2013

Abstract
We develop an empirical method to assess the degree of financial exposure associated with medical care spending among non-elderly US families with employer-sponsored insurance. A key feature of this method is its simplicity – it only requires data on out-of-pocket (OOP) health care spending and total health care spending and does not require detailed knowledge of health insurance benefit design. We apply our method to assess whether families with a chronically ill member face more financial exposure given their level of total spending relative to families with no chronically ill members. We find that the insured chronically ill face more financial exposure than the insured non-chronically ill. Additional analyses suggest that the reason for this additional financial exposure is not that families with a chronically ill member are in different, less generous plans, on average. Rather, families with a chronically ill member have higher spending on certain types of medical services (e.g., pharmaceuticals) that face higher levels of coinsurance. Given recent work on value-based insurance design and coinsurance as an obstacle to medication adherence, our findings suggest that the current design of health plans could jeopardize both the health and the financial well-being of the chronically ill.
Assessment of the Physico-mechanical, Chemical and Colour Characteristics of Potatoes Depending on Tuber Size and Cultivar
Authors: Altuntas Ebubekir , Yilmaz Gungor , Karan Yasin Bedrettin , Dulger Emre 
Published: July 2013

Abstract
In this study, four tuber sizes (28S1 45mm, 45S255mm, 55S365 mm and S465 mm) and three potato cultivars (Jelly, Milva and Sante) were used to assess the variations of physico-mechanical, chemical and colour properties depending on tuber size and potato cultivars. Physico-mechanical properties (geometric mean diameter, sphericity, surface area, bulk and tuber densities, volume, static coefficient of friction, puncture force and deformation), chemical properties (pH, total acidity [TA] and total soluble solid content [TSSC]), and colour characteristics (L
, a
, b
) were determined. The physico-mechanical (geometric properties and puncture force) and chemical properties of potatoes were significantly affected by tuber sizes and cultivars, respectively. pH, TA and TSSC of potato tuber were higher in Milva, TA was higher in Jelly and TSSC was higher in Sante than in those of the other cultivars, respectively.
Crystal structure of 3-(thiophen-2-yl-carbonyl)-4-(thiophen-2-yl)-1-isopropyl-4-piperidinol, C17H21NO2S2
Authors: Aydin Abdullah , Akkurt Mehmet , Gul Halise Inci , Mete Ebru , Sahin Ertan 
Published: July 2013

Abstract C17H21NO2S2, P1̅ (no. 2), a = 5.9254(2) Å, b = 8.9579(2) Å, c = 16.6787(4) Å, α = 92.570(1)°, β = 99.158(2)°, γ = 98.441(2)°, V = 862.4 Å3, Z = 2, Rgt(F) = 0.0557, wRref(F2) = 0.1477, T = 293 K.
Crystal structure of (2,2’-bipyrimidine-κ2N,N')dichloridopalladium(II), PdCl2(C8H6N4), C8H6Cl2N4Pd
Authors: Ha Kwang 
Published: July 2013

Abstract C8H6Cl2N4Pd, monoclinic, P21/c (no. 14), a = 5.0941(7) Å, b = 14.258(2) Å, c = 13.947(2) Å, β = 91.574(2)°, V = 1012.6 Å3, Z = 4, Rgt(F) = 0.0233, wRref(F2) = 0.0666, T = 200 K.
Crystal structure of (acetonitrile-κN-iodido[2-(2-pyridyl)phenyl-κ2N,C] platinum(II), PtI(C11H8N)(CH3CN), C13H11IN2Pt
Authors: Ha Kwang 
Published: July 2013

Abstract C13H11IN2Pt, monoclinic, P21/n (no. 14), a = 11.708(1) Å, b = 5.6266(6) Å, c = 20.214(2) Å, β = 105.161(2)°, V = 1285.2 Å3, Z = 4, Rgt(F) = 0.0241, wRref(F2) = 0.0504, T = 200 K.
Crystal structure of trans-dibromidobis(4-phenylpyridine-κN) platinum(II), PtBr2(C11H9N)2, C22H18Br2N2Pt
Authors: Ha Kwang 
Published: July 2013

Abstract C22H18Br2N2Pt, monoclinic, C2/c (no. 15), a = 9.296(1) Å, b = 24.252(3) Å, c = 8.940(1) Å, β = 98.893(2)°, V = 1991.4 Å3, Z = 4, Rgt(F) = 0.0200, wRref(F2) = 0.0518, T = 200 K.
Crystal structure of pentakis(diisobutylaminium) dichloride tris(tetrachloridoferrate(III)), C40H100Cl14Fe3N5
Authors: Reiss Guido J. 
Published: July 2013

Abstract C40H100Cl14Fe3N5, monoclinic, P21/n (no. 14), a = 19.549(2) Å, b = 20.031(2) Å, c = 19.705(2) Å, β = 117.388(4)°, V = 6851.3(12) Å3, Z = 4, Rgt(F) = 0.0220, wRref(F2) = 0.0529, T = 100 K.