bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phanerozoic Tectonic Evolution, Metallogenesis and Formation of Mineral Systems in China
Authors: CHEN Xuanhua , HAN Lele , DING Weicui , XU Shenglin , TONG Ying , ZHANG Yiping , LI Bing , ZHOU Qi , WANG Ye 
Published: August 2024

AbstractThe continental Asia is mainly composed of three major tectonic regimes, the Tethys, Paleo Asian Ocean, and West Pacific. It underwent multi‐stage plate convergences, ocean‐continent transformations, and subductions, collisions and/or collages, and post collisional (orogenic) extensions in Phanerozoic. Tectonic evolution of the Asia brings up a unique fault system and tectonic geomorphological features in the mainland China. Also, it provides a geodynamic background for the formation and evolution of metallogeneses and mineral systems, resulting in nonuniform distribution of tectono‐metallogenic systems and metallogenic belts. The spatiotemporal distribution of mineral deposits in China and adjacent areas exhibits periodic variation under controlling of the full life Wilson cycle and tectonic evolution, forming the plate convergence‐related mineral system in East Asia. Porphyry Cu deposits are mainly related to compressional systems in Paleozoic and early Mesozoic, and more closely related to post‐collision extensional settings in late Mesozoic and Cenozoic. Orogenic Au deposits mainly formed in post‐orogeny extensional setting. Alkaline rock related rare earth element deposits formed mainly at margins of the North China and Yangtze cratons. Granite‐pegmatite Li and other rare metal deposits formed mainly in early Mesozoic, related to Indosinian post‐orogeny extension. Tectono‐metallogenic systems provide important basis for the prospecting of mineral resources.
Predictors of substance use during treatment for addiction: A network analysis of ecological momentary assessment data
Authors: Serre Fuschia , Gauld Christophe , Lambert Laura , Baillet Emmanuelle , Beltran Virginie , Daulouede Jean‐Pierre , Micoulaud‐Franchi Jean‐Arthur , Auriacombe Marc 
Published: August 2024

AbstractBackground and aimsEcological momentary assessment (EMA) studies have previously demonstrated a prospective influence of craving on substance use in the following hours. Conceptualizing substance use as a dynamic system of causal elements could provide valuable insights into the interaction of craving with other symptoms in the process of relapse. The aim of this study was to improve the understanding of these daily life dynamic inter‐relationships by applying dynamic networks analyses to EMA data sets.Design, setting and participantsSecondary analyses were conducted on time‐series data from two 2‐week EMA studies. Data were collected in French outpatient addiction treatment centres. A total of 211 outpatients beginning treatment for alcohol, tobacco, cannabis, stimulants and opiate addiction took part.MeasurementsUsing mobile technologies, participants were questioned four times per day relative to substance use, craving, exposure to cues, mood, self‐efficacy and pharmacological addiction treatment use. Multi‐level vector auto‐regression models were used to explore contemporaneous, temporal and between‐subjects networks.FindingsAmong the 8260 daily evaluations, the temporal network model, which depicts the lagged associations of symptoms within participants, demonstrated a unidirectional association between craving intensity at one time (T0) and primary substance use at the next assessment (T1, r = 0.1), after controlling for the effect of all other variables. A greater self‐efficacy at T0 was associated with fewer cues (r = −0.04), less craving (r = −0.1) and less substance use at T1 (r = −0.07), and craving presented a negative feedback loop with self‐efficacy (r = −0.09).ConclusionsDynamic network analyses showed that, among outpatients beginning treatment for addiction, high craving, together with low self‐efficacy, appear to predict substance use more strongly than low mood or high exposure to cues.
Spinocerebellar ataxia type 10 and Huntington disease‐like 2 in Venezuela: Further evidence of two different ancestral founder effects
Authors: Paradisi Irene , Arias Sergio , Ikonomu Vassiliki 
Published: August 2024

AbstractIntroductionThe American continent populations have a wide genetic diversity, as a product of the admixture of three ethnic groups: Amerindian, European, and African Sub‐Saharan. Spinocerebellar ataxia type 10 (SCA10) and Huntington disease‐like 2 (HDL2) have very ancient ancestral origins but are restricted to two populations: Amerindian and African Sub‐Saharan, respectively. This study aimed to investigate the genetic epidemiological features of these diseases in Venezuela.MethodsIn‐phase haplotypes with the expanded alleles were established in seven unrelated index cases diagnosed with SCA10 and in 11 unrelated index cases diagnosed with HDL2. The origins of remote ancestors were recorded.ResultsThe geographic origin of the ancestors showed grouping in clusters. SCA10 had a minimal general prevalence of 1:256,174 families in the country, but within the identified geographic clusters, the prevalence ranged from 5 per 100,000 to 43 per 100,000 families. HDL2 had a general prevalence of 1:163,016 families, however, within the clusters, the prevalence ranged from 31 per 100,000 to 60 per 100,000 families. The locus‐specific haplotype shared by all families worldwide, including the Venezuelans, supports a single old ancestral origin in each case.ConclusionKnowing the genetic ancestry and geographic origins of patients in Ibero‐American mixed populations could have significant diagnostic implications; thus, both diseases in Venezuela should always be first explored in patients with a suggestive phenotype and ancestors coming from the same known geographic clusters.
Examining collinearities
Authors: Shabuz Zillur R. , Garthwaite Paul H. 
Published: August 2024

SummaryThe cos‐max method is a little‐known method of identifying collinearities. It is based on the cos‐max transformation, which makes minimal adjustment to a set of vectors to create orthogonal components with a one‐to‐one correspondence between the original vectors and the components. The aim of the transformation is that each vector should be close to the orthogonal component with which it is paired. Vectors involved in a collinearity must be adjusted substantially in order to create orthogonal components, while other vectors will typically be adjusted far less. The cos‐max method uses the size of adjustments to identify collinearities. It gives a coherent relationship between collinear sets of variables and variance inflation factors (VIFs) and identifies collinear sets using more information than traditional methods. In this paper we describe these features of the method and examine its performance in examples, comparing it with alternative methods. In each example, the collinearities identified by the cos‐max method only contained variables with high VIFs and contained all variables with high VIFs. The collinearities identified by other methods did not have such a close link to VIFs. Also, the collinearities identified by the cos‐max method were as simple as or simpler than those given by other methods, with less overlap between collinearities in the variables that they contained.
Letter: Algorithmic NIT approaches to identify advanced liver fibrosis in patients with MASLD: Authors' reply
Authors: McPherson Stuart , Dyson Jessica K. , Jopson Laura , Masson Steven , Patel Preya , Anstee Quentin M. 
Published: August 2024

LINKED CONTENTThis article is linked to McPherson et al papers. To view these articles, visit https://doi.org/10.1111/apt.18061 and https://doi.org/10.1111/apt.18176
Adverse events associated with benznidazole treatment for Chagas disease in children and adults
Authors: Cruz Cintia Valeria , Rabinovich Andres , Moscatelli Guillermo , Moroni Samanta , González Nicolas , Garcia‐Bournissen Facundo , Ballering Griselda , Freilij Hector , Altcheh Jaime 
Published: August 2024

AimsChagas disease (ChD) affects approximately 7 million people in Latin America, with benznidazole being the most commonly used treatment.MethodsData from a retrospective cohort study in Argentina, covering January 1980 to July 2019, was reanalysed to identify and characterize benznidazole‐related adverse drug reactions (ADRs).ResultsThe study included 518 patients: 449 children and 69 adults (median age in children: 4 years; adults: 25 years; age ranges: 1 month–17.75 years and 18–59 years, respectively). The median benznidazole doses received were 6.6 mg/kg/day for at least 60 days in children and 5.6 mg/kg/day for a median of 31 days in adults. Overall, 29.34% (152/518) of patients developed benznidazole‐related ADRs, with an incidence of 25.83% (116/449) in children and 52.17% (36/69) in adults (odds ratio [OR] = 0.32, 95% confidence interval [CI] = 0.19–0.54, P < .001). The incidence rate was 177 cases per 1000 person‐years (95% CI = 145–214) in children and 537 per 1000 person‐years (95% CI = 360–771) in adults. There were 240 ADRs identified, primarily mild to moderate. Severe ADRs occurred in 1.11% (5/449) of children and 1.45% (1/69) of adults. The skin was the most affected system. A total of 10.23% (53/518) of patients discontinued treatment. More adults than children discontinued treatment (OR = 3.36, 95% CI = 1.7–6.4, P < .001).ConclusionsAlthough 29.34% of patients experienced ADRs, most were mild to moderate, indicating a manageable safety profile for benznidazole. While optimized dosing schedules and new drugs are needed, avoiding benznidazole solely due to safety concerns is not justified.
Improving cefazolin exposure in critically ill children using a population pharmacokinetic model
Authors: Rivaud Clémence , Oualha Mehdi , Salvador Elodie , Bille Emmanuelle , Callot Delphine , Béranger Agathe , Bournaud Leo Froelicher , Rouillon Steeve , Toubiana Julie , Benaboud Sihem , Renolleau Sylvain , Treluyer Jean Marc , Hirt Déborah , de Cacqueray Noémie 
Published: August 2024

AimsPopulation pharmacokinetics (PK) models may be effective in improving antibiotic exposure with individualized dosing. The aim of the study is to assess cefazolin exposure using a population PK model in critically ill children.MethodsWe conducted a single‐centre observational study including children under 18 years old who had cefazolin plasma monitoring before and after a cefazolin model implementation. The first concentration at steady state of each cefazolin course was analysed. The optimal exposure was defined by concentration values ranging from free concentration over four times the minimal inhibitory concentration (MIC) for 100% of the dosing interval to total trough or plateau concentration under 100 mg. L−1.ResultsA total of 58 patients were included, of whom 39 and 19 children received conventional dosing or model‐informed dosing, respectively. Median [range] age was 2.3 [0.1–17] years old, and median weight was 14.2 [2.9–72] kg. There were more continuous infusions (CI) in the model group than in the conventional group (n = 19/19 [100%] vs. n = 23/39 [59%]). Compared to conventional dosing, model‐informed dosing provided more optimal exposure (n = 17/39 [44%] vs. n = 15/19 [79%], P = .01) and less underexposure (n = 18/39 [46%] vs. n = 2/19 [10%], P = .008), without increasing overexposure (n = 4/39 [10%] vs. n = 2/19 [11%], P = 1). Moreover, the time to C‐reactive protein decrease by 50% was significantly shorter in the model group than the conventional group (3 [0.5–13] vs. 4 [1–34]; P = .045).ConclusionsUse of individualized cefazolin model‐informed dosing improves critically ill children's exposure. Further studies are needed to assess the clinical benefit of cefazolin PK model application.
Analysis of Depression and Anxiety Scores Following Initiation of Elexacaftor/Tezacaftor/Ivacaftor in Adults With Cystic Fibrosis
Authors: Pudukodu Harish , Powell Margret Z. , Ceppe Agathe , Donaldson Scott H. , Goralski Jennifer L. , Sowa Nathaniel A. 
Published: August 2024

ABSTRACTObjectiveElexacaftor/tezacaftor/ivacaftor (E/T/I) has provided life‐changing pharmacotherapy for many people with cystic fibrosis (CF), but conflicting literature exists regarding the effect on mental health. While some reports suggest E/T/I may induce adverse psychiatric symptoms, others report improvements in mental health symptoms. To add to this growing body of knowledge, we retrospectively analyzed depression and anxiety symptoms before and after E/T/I initiation in adults with CF at a single large US CF center.MethodPatient Health Questionnaire‐9 (PHQ‐9) and Generalized Anxiety Disorder‐7 (GAD‐7) scores recorded in a database were studied. Patients with scores collected before and after E/T/I initiation were included. Regression analyses described associations between score changes and age, race, ethnicity, sex, CFTR variant, and prior depression and/or anxiety diagnoses. Secondary analyses examined possible confounding effects of the COVID‐19 pandemic.ResultsThere was no change in mean GAD‐7 (0.5 ± 5.3, p = 0.41) or PHQ‐9 (−0.02 ± 6.0, p = 0.97) scores following initiation of E/T/I (N = 86). A trend between a prior diagnosis of depression and worsening in PHQ‐9 post‐E/T/I was observed (OR 3.58; p = 0.054).ConclusionsTreatment with E/T/I does not lead to changes in depression or anxiety symptoms at the population level in this single center cohort study. A prior diagnosis of depression trended towards an increased odds of worsening PHQ‐9 scores after E/T/I initiation.
Measuring the Impact of Postsimultaneous Pancreas–Kidney Transplantation Complications: Comparing the Comprehensive Complication Index and Clavien–Dindo Classification
Authors: Nian Yeqi , Hu Lu , Cao Yu , Wang Zhen , Wang Hui , Feng Gang , Zhao Jie , Zheng Jianming , Song Wenli 
Published: August 2024

ABSTRACTIntroductionThe Clavien–Dindo classification (CDC) is commonly used for assessing postoperative complications; however, it may not be comprehensive. A comprehensive complication index (CCI) was introduced to address this limitation. This study aimed to compare the effectiveness of the CCI and CDC in evaluating the complications after simultaneous pancreas–kidney (SPK) transplantation.MethodsData were collected from patients who underwent SPK transplantation at our center between February 2018 and February 2021. Complications encountered during hospitalization were assessed using both the CDC and CCI. Linear regression analyses were performed to identify the factors related to postoperative length of stay (PLOS).ResultsOverall, 125 patients were included, with an average age of 46.87 years. Type 2 diabetes was present in 79% of the recipients. Among them, 117 patients experienced postoperative complications of CDC grades I (2.4%), II (57.6%), IIIa (8.0%), IIIb (9.6%), IVa (14.4%), IVb (0.8%), and V (0.8%) postoperative complications. The median CCI for the entire cohort was 37.2. Spearman's correlation analysis revealed significant associations between the CDC and PLOS and the CCI and PLOS. Notably, CCI exhibited a stronger correlation with PLOS (CCI: ρ = 0.698 vs. CDC: ρ = 0.524; p = 0.024).ConclusionThe CCI demonstrated a stronger correlation with PLOS than CDC. Our finding suggests that the CCI may be a useful tool for comprehensively assessing complications following SPK transplantation.
Microvascular disease and its association with dementia in patients with type 2 diabetes: A nationwide cohort study in Taiwan
Authors: Yen Yu‐Hsin , Yen Fu‐Shun , Ko Fu‐Shun , Wei James Cheng‐Chung , Huang Yuhan , Yu Teng‐Shun , Hwu Chii‐Min , Hsu Chih‐Cheng 
Published: August 2024

AbstractAimTo assess the likelihood of dementia in individuals with type 2 diabetes (T2D), distinguishing between those with and without microvascular diseases.MethodsLeveraging the National Health Insurance Research Database in Taiwan, we identified individuals newly diagnosed with T2D from 1 January 2009 through 31 December 2014. Multivariable Cox proportional hazard models were used to compare the risk of outcomes.ResultsIndividuals with microvascular disease had a significantly higher risk of all‐cause dementia (adjusted hazard ratio [95% confidence interval] 1.13 [1.09, 1.17]) compared with matched individuals without microvascular disease. In addition, individuals with diabetic kidney disease and diabetic neuropathy were associated with a significantly increased risk of Alzheimer's disease (1.16 [1.02, 1.32] and 1.14 [1.03, 1.27]), vascular dementia (1.21 [1.06, 1.38] and 1.14 [1.02, 1.28]) and other dementia (1.11 [1.04, 1.19] and 1.10 [1.04, 1.16]), respectively, compared with those without microvascular disease.ConclusionsThis nationwide cohort study showed that patients with T2D and microvascular disease, particularly diabetic kidney disease and diabetic neuropathy, were associated with a significantly higher risk of Alzheimer's disease, vascular dementia, other dementia and all‐cause dementia than those without microvascular disease.
Inclusive Mission in Together towards Life in an Indigenous Naga Context
Authors: Longchar Sashimongla 
Published: August 2024

Abstract“Mission from the margins” is an important concept to help move toward a renewed vision of ecumenical mission praxis. This article examines the idea of mission from the margins in the context of the Nagas, an Indigenous (tribal) people in Northeast India. The article's aim is to identify the main internal factors that drive the marginalization of the Nagas, such as geographical isolation, poverty and migration, ecological injustice, exploitation of identity, culture, and values. This marginalization will be addressed in conversation with the mission document of the World Council of Churches, Together towards Life, exploring the possibilities of inclusive mission for a just community.
Effects of thickness debit and stress concentration on superalloy DZ125 subjected to cyclic loading
Authors: Gan Yang , Yang Qinzheng , Zhao Yi , Hu Xiaoan 
Published: August 2024

AbstractIn this paper, the thickness debit and stress concentration effects of a nickel‐based directionally solidified superalloy were investigated through strain‐controlled low cycle fatigue (LCF) and creep–fatigue interaction (CFI) experiments. Compared to the fatigue lives of solid specimens provided in the existing literature, the results of this paper indicate that when the wall thickness of the specimen is reduced from 5 to 1.125 mm, the fatigue life with different strain amplitudes decreases by about 45%. When film‐cooling holes (FCHs) are introduced into the hollow specimens, the fatigue life is further reduced by about 25%. Based on the observation of the scanning electron microscope (SEM), the formation mechanisms of the thickness debit and stress concentration effects under LCF and CFI loads were revealed. Subsequently, two parameters, the “wall‐thickness coefficient” and “hole coefficient,” were proposed to establish a new fatigue life prediction method.
Exploring Healthcare Paradoxes in Hospital Haemodialysis—A Qualitative Study
Authors: Andersen‐Hollekim Tone , Hole Torstein , Solbjør Marit 
Published: August 2024

ABSTRACTIntroductionThe complex logics of healthcare systems inherit paradoxes that can lead to interpersonal conflicts impacting both patients and professionals. In this study, we aimed to identify and explore tensions and conflicts arising from paradoxes within hospital haemodialysis.MethodsWe conducted a secondary supplementary analysis to previously collected qualitative data, including individual interviews with 11 patients and 10 nephrologists and focus groups involving a total of 13 haemodialysis nurses. Data were collected in Norway through three primary studies focused on exploring experiences of patient participation. For the current study, we employed thematic analysis.ResultsPatient–professional conflicts emerged in three fundamental areas: (1) the hospital haemodialysis treatment, in which patients' views of treatment diverged from those of professionals, (2) patient–professional responsibility that became a negotiation point, with differing views on responsibilities, and (3) time, in which professional time took precedence over patients’ time, indirectly impacting patients due to resource allocation. These conflicts stemmed from paradoxes driven by unevenly validated principles, conflict of interest, and conceptual ambiguity.ConclusionAltering healthcare logics by bringing in new perspectives or clarifying conceptual ambiguity could mitigate patient–professional conflicts. However, changing existing healthcare logics may give rise to new paradoxes and conflicts, which health services at various levels must address.Patient or Public ContributionThis secondary analysis utilized previously collected data from a project that did not involve patient or public contribution.
Prognostic performance of FIGO 2023 endometrial carcinoma staging: a comparison to FIGO 2009 staging in the setting of known and unknown molecular classification
Authors: Libert Diane , Hammer Phoebe M , Hui Caressa , Kidd Elizabeth A , Folkins Ann K , Longacre Teri , Yang Eric J , Charu Vivek , Howitt Brooke E 
Published: August 2024

AimsThe 2023 FIGO staging criteria for endometrial cancer (EC) introduced marked changes from the 2009 version. The full implication of these changes for patient diagnosis and treatment is unknown. We evaluate the differences in staging and prognostication between the two systems, with and without inclusion of molecular classification.Methods and resultsWe assigned (1) FIGO 2009, (2) 2023 molecular‐agnostic and (3) 2023 molecular‐informed stages to 404 fully staged and molecularly classified patients with EC. Disease‐specific and progression/relapse‐free survival were analysed via the Kaplan–Meier method and compared with log‐rank testing; 118 of 252 (47%) FIGO 2009 stage I patients were upstaged based on histopathological findings alone. Stage I/II subgroup survival distribution analysis showed a worse prognosis in FIGO 2023 IIB and IIC patients. In the molecular‐informed FIGO 2023 system, three of 15 (20%) POLE‐mutated stage I/II cases were downstaged from FIGO 2009 and eight (53%) were downstaged from molecular‐agnostic FIGO 2023. Fifty‐one of 60 (85%) p53‐abnormal tumours were upstaged from the FIGO 2009, whereas 13 of 60 (22%) were upstaged from the 2023 molecular‐agnostic stage. Molecular classification improved prognostic stratification for both 2009 and 2023 FIGO systems.ConclusionsDownstaging based on POLE mutation more accurately represents patient outcomes. However, in the absence of known POLE status, applying molecular‐agnostic FIGO 2023 criteria for stage I/II disease should be conducted with caution. For aggressive histotypes, additionally reporting FIGO 2009 stage should be considered. Upstaging based on substantial lymphovascular space invasion, aggressive histotype with any myometrial invasion and abnormal p53 improves prognostic discernment. Further subdivisions within stage I/II provide minimal additional prognostic information.