bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Statistical Study of Calcifying Epithelioma, Focusing on the Sites of Origin
Authors: Noguchi Hiromitsu , Hayashibara Toshio , Ono Tomomichi 
Published: April 2015

AbstractWe statistically investigated 396 lesions taken from 355 cases of calcifying epithelioma. The distribution of these lesions did not correlate with the density of the hair follicles, but it was in accord with the distribution of intermediate hairs, such as those in the hair border. This relationship may have etiologic significance.
Elevated Serum CA125 in Progressive Systemic Sclerosis with Pleural Effusion
Authors: Kimura Kyoko , Ezoe Kazuhiko , Yokozeki Hiroo , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractThe elevation of tumor markers in benign diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, or diabetes mellitus has been reported recently. We had the opportunity to observe a female patient with progressive systemic sclerosis (PSS) and pleuritis who demonstrated a high level of CA125 in her pleural effusion and blood serum. The purpose of this report is to describe this case. We also investigated whether tumor markers are elevated in collagen disease. We measured the serum levels of CA125 and CA19‐9 in our case of PSS with pleuritis, 27 female patients with collagen diseases including SLE, PSS, dermatomyositis and Sjögren syndrome, and 11 normal females as controls.Compared with the normal controls, there was no evident elevation of CA19‐9 or CA125 levels in collagen diseases except in our case.Elevated serum CA125 may be one of the indicators of pleural effusion in collagen disease.
Polysialogangliosides Expressed by Amelanotic Melanoma: A Possible Explanation for the Poor Response to Anti‐monosialoganglioside Antibody 202 in a Patient with Melanoma
Authors: Hamanaka Sumiko , Ota Takahisa , Asagami Chidori , Gondo Toshikazu , Yamaguchi Yasunori , Tai Tadashi , Kawashima Ikuo , Irie Reiko F. , Otsuka Fujio 
Published: April 2015

AbstractA 52‐year‐old Japanese woman developed numerous amelanotic metastatic melanomas on the skin and in various organs three years after a surgical operation for primary melanoma on the right axilla. The patient was treated with monosialoganglioside specific monoclonal antibody 202; however, no apparent clinical effects were observed. Ganglioside analysis of a metastatic tumor demonstrated that it expressed GM3, GM2, GD3, GD2, and polysialogangliosides. Since polysialogangliosides rarely appear in melanomas, their expression may explain the patient's poor response to MAb 202. The relationship between ganglioside composition and the effect of anti‐ganglioside monoclonal antibody is discussed.
Basal Cell Carcinoma with Eccrine Differentiation
Authors: Nogita Toshitatsu , Ohta Asako , Hidano Akira , Watanabe Shinichi , Kawashima Makoto 
Published: April 2015

AbstractWe describe a light, electron microscopic, and immunohistochemical study of basal cell carcinoma with eccrine differentiation. The cytoplasm did not stain with fat stain on cryostat sections, but contained numerous gland‐like structures. Immunohistochemistry on formalin fixed, paraffin embedded tissues using antibodies to human involucrin, thirteen kinds of cytokeratin, S‐100 protein, and carcinoembryonic antigen (CEA) was performed. We found that tumor cells were positive for keratin, PKK1, MA‐903, No 8, No 19, AE 1, AE 3, and 5+8. Tumor cells were negative for S‐100 protein, CEA, and the other antigens examined. Electron microscopy demonstrated short microvilli and amorphous materials within the intracytoplasmic cavity. We concluded that this tumor is basal cell carcinoma with eccrine differentiation.
Erythema Induratum with Pulmonary Tuberculosis: Report of Three Cases
Authors: Cho Kwang Hyun , Lee Dong Youn , Chun Ho Su , Eun Hee Chul , Han Sung Koo 
Published: April 2015

AbstractThree cases of erythema induratum which occurred in the patients with pulmonary tuberculosis are described. The cutaneous lesions were violaceous, indurated nodules on both lower legs above the malleoli. Histologically, tuberculoid granuloma with caseation necrosis was found in one case; necrotizing vasculitis was the prominent finding in other two cases. The erythema induratum promptly responded to antituberculous therapy. We believe that, in light of these cases, the association between erythema induratum and infection with tubercle bacilli should be re‐emphasized.
Gamma‐Interferon Therapy for Severe Cases of Atopic Dermatitis of the Adult Type
Authors: Nishioka Kiyoshi , Matsunaga Tsuyoshi , Katayama Ichiro 
Published: April 2015

AbstractRecombinant gamma interferon (IFN‐γ) was employed to treat adult‐type atopic dermatitis. Eight cases received subcutaneous injections of 500,000 JRU of IFN‐γ for 8 weeks. They responded relatively well to this treatment; however, the overall response to the treatment was not significantly better than that to conventional therapy in the control group. There was no significant suppression of itch or erythema. Swelling was reduced at the 8th week in the treatment group. Frequency of flushing attacks on the face was reduced and disappeared within four weeks in 6 of these patients; however, a similar reduction of frequency was observed in the control group. Papular and lichenified lesions on the trunk and extremities responded significantly to the treatment later than 5 weeks after its initiation. Serum IgE level was not affected by the treatment. Seven had the same level of serum IgE before and after the treatment. The serum cytokine level in the treated patients was also unaltered. Therefore, although IFN‐γ treatment has some benefit in the treatment of severe cases of atopic dermatitis, it should be applied to limited cases because of its high cost.
The Effects of Non‐Interval PUVA Therapy on the Plaque Stage of Mycosis Fungoides
Authors: Nakamura Motonobu , Kobayashi Setsu , Matsubara Kunihiko , Tanaka Toshihiro , Furukawa Fukumi , Imamura Sadao 
Published: April 2015

AbstractThe effectiveness of non‐interval topical PUVA treatment was studied in four patients with mycosis fungoides at the plaque stage. Five regions of each patient were exposed to UVA immediately, 30 minutes, 60 minutes, 90 minutes, and 120 minutes, after topical application of 8‐methoxypsoralen, respectively. The effects of these treatments were evaluated by clinical appearance and histological findings after the 20th treatment. All five regions were more improved clinically and histologically than the control region, which was not given PUVA therapy. There were no clear differences clinically among these five regions. Biopsy specimens from each region revealed the disappearance of epidermotropism and a marked decrease in atypical mononuclear cell infiltrations in the dermis. From these data, we concluded that there were no clear differences between these five treatments clinically or histologically and that non‐interval PUVA therapy is useful for the early stages of mycosis fungoides. To our knowledge, this is the first report of non‐interval PUVA therapy for mycosis fungoides.
Assessment of Cellular Proliferation of Sebaceous Neoplasms by AgNOR Counts and Immunohistochemical Demonstrations of PCNA and Ki‐67
Authors: Ansai Shin‐ichi , Koseki Shin , Hozumi Yutaka , Kondo Shigeo , Aso Kazuo 
Published: April 2015

AbstractWe assessed cellular proliferation of sebaceous neoplasms by AgNOR counts and the immunohistochemical demonstration of proliferating cell nuclear antigen (PCNA) and Ki‐67, using formalin‐fixed and paraffin‐embedded tissue specimens. We used three categories of sebaceous neoplasms: four cases of sebaceoma, three cases of basal cell carcinoma with sebaceous differentiation (BCSD), and seven cases of sebaceous carcinoma (SC). Significant differences were noted between SC and non‐SC tumors (sebaceoma and BCSD) in AgNOR counts and semi‐quantitative grading of PCNA and Ki‐67 labelling indices (P<0.01). When a cut‐off value of 6 was chosen, the AgNOR value discriminated SC from non‐SC tumors with high specificity and sensitivity. When a cut‐off value of 25% was chosen, PCNA and Ki‐67 labelling indices also discriminated between these tumors. Significant differences were not observed between sebaceoma and BCSD with PCNA and Ki‐67 labelling indices. AgNOR counts of BCSD were a little higher than those of sebaceoma, but the number of cases was too small to perform statistical assessment. We consider AgNOR counts and semi‐quantitative grading of PCNA and Ki‐67 labelling indices to be useful in differentiating SC from BCSD and sebaceoma.
Cutaneous Malignant Hemangioendothelioma: Clinical and Histopathological Observations of Nine Patients and a Review of the Literature
Authors: Bhutto Abdul Manan , Uehara Keishi , Takamiyagi Atsushi , Hagiwara Keisuke , Nonaka Shigeo 
Published: April 2015

AbstractNine patients with cutaneous malignant hemangioendothelioma (CMHE) were reported in Okinawa. All the patients were elderly, between 75 and 93 years of age. Four patients were males and five were female. The onset of the disease ranged from 1 to 9 months before the first visit. Eight patients had lesions on the scalp, and one, on the face and cheek. The lesions were in the form of exudative erythematous purpura, erythematous purpuric ulcers, and tumors. One patient developed a systematic metastasis involving the lungs, heart and intestine, and two patients had local metastasis to the cervical lymph nodes. Histopathologically, the tumor vessels were proliferated irregularly and showed anastomosis. The lumens were lined by large and atypical endothelial cells. Most of the specimens were infiltrated with large numbers of red blood cells. By electron microscope, Weibel‐palade bodies were found inside the tumor cells located at the peripheral part of the lesion. The patients were treated by irradiation, IL‐2 injection, and/or surgery. They were treated for 3 months to 2 years. Eight patients died between 4 to 24 months after the onset of disease and one has survived. The prognosis was poor.
A Case of Multiple Eccrine Porocarcinoma with Stepping‐Stone Distribution on the Foot
Authors: Ujihara Mayumi , Hamanaka Sumiko , Hamanaka Yuichiro , Kamei Toshiaki 
Published: April 2015

AbstractAn 89‐year‐old woman had three tumors of several years' duration in a stepping‐stone distribution on the dorsum of her right foot. The two larger ones were diagnosed histologically as eccrine porocarcinomas, and the smallest of the three shared many clinical similarities with them. Eccrine porocarcinoma is a rare malignant tumor. We describe this peculiar case in which three tumors developed in the same region and discuss how they might have occurred. It is most likely that the three tumors of this case originated from nevoid tumors, and that the individual lesions exhibited malignant changes.
Erythema Gyratum Repens Unassociated with Underlying Malignancy
Authors: Kawakami Tamihiro , Saito Ryuzo 
Published: April 2015

AbstractA case of erythema gyratum repens occurring in a 62‐year‐old woman is presented together with a review of the literature. Evaluation and follow‐up for the development of malignancy over a 32‐month period failed to reveal any evidence of malignancy. Formerly, all cases of erythema gyratum repens were evaluated in terms of an association with an underlying malignant disorder. To date, only sixty cases have been reported in the literature; 14 (23%) were not found to be associated with any neoplasm. Therefore, this term is now also used for cases unassociated with malignancy. Erythema gyratum repens is a cutaneous eruption with a characteristic diagnostic morphology resembling a wood grain pattern.
Electron Microscopic Observations of Epithelioid Cell Granulomas Experimentally Induced by Prototheca in the Skin of Mice
Authors: Horiuchi Yasuhiro , Masuzawa Mikio 
Published: April 2015

AbstractElectron microscopic analysis was conducted on epithelioid cell granulomas experimentally induced by prototheca in the skin of mice. In BALB/c mice, epithelioid cell granulomas were easily induced. Each cell had a round nucleus with euchromatin on the margin, abundant cytoplasmic organelles, and particularly abundant rough endoplasmic reticulum (rER). Cells with a plasmacytoid appearance were the most common. Fibroblast‐like epithelioid cells were sometimes observed. The whole body and cell membrane of an organism was usually within the cytoplasm of epithelioid cell. In ICR mice, epithelioid cell granulomas were not easily induced. Cells which had ingested whole organisms had spindle shaped and/or oval nuclei with marginated heterochromatin and with abundant dilated rER. Near completion of organism digestion, the cells had irregular and/or indented nuclei with marginated heterochromatin and often one or two distinct nucleoli. The cytoplasm was often replaced with numerous phagocytic vacuoles. At higher magnification, secondary lysosomes and Golgi complexes forming Golgi lamellae could be seen in the cells in which cytoplasmic organelles such as endoplasmic organelles and mitochondria were abundantly present. In contrast to the BALB/c mice, the remnants of digested organisms, split up into many small pieces, could be seen in the cytoplasm. The cells with a fibroblast‐like appearance were most frequent, but plasmacytoid cells were sometimes observed. In the present study, the ultrastructural features of epithelioid cells in BALB/c and ICR mice clearly differed. Plasmacytoid cells were the most abundant in BALB/c mice, while fibroblast‐like cells were in ICR mice.
Werner's Syndrome Associated with Basal Cell Epithelioma
Authors: Morita Kazumasa , Miwa Mitsuru 
Published: April 2015

AbstractA Japanese female with Werner's syndrome associated with basal cell epithelioma is reported. Werner's syndrome is prone to malignancy, and many such cases have been reported. However, basal cell epithelioma is rare in Werner's syndrome. In the presented case, a black nodule about 2 cm in diameter with erosion developed on her abdomen. The histology revealed the findings of basal cell epithelioma.
A Single Lesion Demonstrating Features of Eccrine Poroma and Poroid Hidradenoma
Authors: Misago Noriyuki , Kohda Hiromu 
Published: April 2015

AbstractA case of a single poroma lesion with the features of eccrine poroma and poroid hidradenoma is reported. The patient was a 61‐year‐old woman with a soft nodule, light brown in color, located on the posterior aspect of the right knee and containing a pigmented papular lesion in its center. The histological features of the papular lesion and the nodule were consistent with those of eccrine poroma and poroid hidradenoma, respectively. The eccrine poroma portion consisted mostly of poroid cells. The number of cuticular cells was slightly greater than that of poroid cells in the poroid hidradenoma portion. The cuticular cells in this portion as well as the poroid cells in both portions were immunohistochemically positive for epithelial membrane antigen. The findings in this case suggest that there is a close relationship between eccrine poroma and poroid hidradenoma and support the view that poroid hidradenoma is a type of poroma.
The Porphyrias: A Brief Overview Based on 25 Years of Experience (1969–1994) by the Department of Dermatology of the Hospital Clinic and Faculty of Medicine of Barcelona, Spain
Authors: Mascaro Jose M. 
Published: April 2015

AbstractThe porphyrias are uncommon diseases caused by enzymatic deficiencies in the heme pathway. In the 25 year period 1969–1994, the Department of Dermatology of the Hospital Clinic of Barcelona has been able to study 793 cases of porphyria (724 cases of PCT, 27 of EPP, 26 of PV, 5 of CEP, 5 of HEP, 5 of AIP, 1 of HCP).Homozygous expression of an enzymatic deficiency in the heme pathway produces severe disease. Commonly, clinical manifestations appear in the homozygous state (the autosomal recessive porphyrias). However, homozygous forms of autosomal dominant porphyrias may occur exceptionally.Moreover, there are cutaneous porphyrias whose clinical manifestations do not permit dermatologists to classify them clearly into one of the well‐defined syndromes. These uncommon and atypical forms are difficult to recognize without biochemical and enzyme studies.The porphyrias have a wide clinico‐biochemical spectrum, including a large proportion of well defined diseases. Nevertheless, atypical forms occur and may be difficult to evaluate. It is important to note the genetic heterogeneicity of porphyrias, which accounts for the varying phenotypic expression.
Leukemoid Reaction in Epidermal Squamous Cell Carcinoma
Authors: Kiyosawa Tomoharu , Hirano Shigeki , Nakamura Jinko , Murata Satoru , Demitsu Toshio , Kato Hideyuki , Yaoita Hideo 
Published: April 2015

AbstractThere have been no previous concrete reports of leukemoid reactions associated with squamous cell carcinoma originating in cutaneous tissue. Here we report a case of epidermal squamous cell carcinoma of the sacral region and an associated leukemoid reaction. The tumor invaded deeply and destroyed both the sacrum and coccyx. The white blood cell count was greater than 20,000/mm3. After resection of the tumor, white blood cells transiently decreased, but did not fall under 10,000/mm3. Post‐operative infection by methicillin‐resistant Staphylococcus aureus and Bacteroides caccae caused sepsis and further elevation of the leukocytes to greater than 50,000/mm3. The leukemoid reaction in the case appeared to have been caused initially by direct invasion of bone by epidermal squamous cell carcinoma and later by severe infection.
Tumoral Calcinosis: Report of a Case and Brief Review of the Literature
Authors: Abraham Zeev , Rozner Itzhak , Rozenbaum Michael 
Published: April 2015

AbstractA patient with a 32‐year history of tumoral calcinosis is described. The calcified lesions involved the soft tissues in the hips, shoulders, and ankles. Periodically, a chalky semifluid material extruded through several cutaneous sinuses. Laboratory tests including serum calcium concentration were normal, except for slight elevation of serum phosphorous levels. Ophthalmologic examination revealed the interesting finding of subretinal angioid streaks. The dental radiograms disclosed pathognomonic short bulbous roots and partial obliteration of pulp cavities, while the radiological evaluation of the tumoral masses revealed typical features of tumoral calcinosis.
Milia Arising in Herpes Zoster Scars
Authors: Lee Won Soo , Kim Soo Jung , Ahn Sung Ku , Lee Seung Hun 
Published: April 2015

AbstractMilia caused by proliferative tendencies of the epithelium after injury may occur in areas of bullous eruption (10). Even though the possibility of milia arising in herpes zoster scar is real, it has not been reported previously.We describe a case of milia arising in herpes zoster scars as an another example of milia occurring in traumatized skin.
Localized Bullous Pemphigoid of the Vulva
Authors: Urano Shoko 
Published: April 2015

AbstractI report a 78‐year‐old female patient with multiple erosive and erythematous inflammatory lesions of the vulva of seven months duration. She was diagnosed as bullous pemphigoid based on the following findings: subepidermal blister in the histological examination, linear deposition of IgG and C3 at the basement membrane zone on direct immunofluorescence studies, and positive IgG deposition on the epidermal side of saline‐split normal skin on the indirect immunofluorescence study.
Accuracy of the Clinical Diagnosis of Recessive X‐Linked Ichthyosis vs Ichthyosis Vulgaris
Authors: Cuevas‐Covarrubias Sergio A. , Kofman‐Alfaro Susana H. , Palencia Angélica Beirana , Díaz‐Zagoya Juan C. 
Published: April 2015

AbstractThe present study analyzes the accuracy of the clinical diagnosis of X‐linked ichthyosis (XLI) vs ichthyosis vulgaris (IV), in a sample of Mexican patients. The study was double blind, using steroid sulfatase (STS) activity as the golden standard. Twenty male patients were included; 16 corresponded to XLI and 4 to IV. The clinical diagnosis was correct in 9 of the 16 XLI cases (56%) and in 2 of the 4 IV cases (50%). Some clinical findings in XLI, such as cryptorchidism in patients and delayed labor in their mothers, were important features for diagnosis. Statistical analysis of the results showed: among physicians (n=2) Kappa value 0.50, specific concordance 0.40, and absolute concordance 0.75; other values were sensibility 0.56, specificity 0.50, positive predictive value 0.82, negative predictive value 0.22, accuracy 0.55, prevalence 0.80. In conclusion, the differential diagnosis of XLI and IV is very difficult, and we consider that this is not explained either by personal skills or by other conditions. It could be attributed to the similarities in skin manifestations of these two diseases. The performance of the STS assay is imperative in order to correctly diagnose the disease and offer adequate genetic counseling.
A Case of Ki‐1 Positive Anaplastic Large Cell Lymphoma Transformed from Mycosis Fungoides
Authors: Kudo Yoshiko , Katagiri Kazumoto , Ise Tomoko , Imaraura Yuzo , Takayasu Susumu 
Published: April 2015

AbstractA case of cutaneous Ki‐1 positive anaplastic large cell lymphoma which developed in the plaque stage of mycosis fungoides was described. A 73‐year‐old woman who had suffered from pruritic scaly eruptions over her entire body for more than two decades was admitted because of an ulcerated tumor measuring 45 times 55 times 15 mm and several satellite tumors on the buttock. All tumorous lesions were resected without recurrence to date. Histochemical study revealed that the tumor consisted of large anaplastic cells which were Ki‐1 (CD30)‐positive and LCA‐negative. Some of the erythematous plaques contained LCA‐positive, small‐sized atypical lymphocytes. In other plaques which developed two years later, there were large Ki‐1‐positive atypical cells. In the specimens obtained from the tumor and the plaque, the same pattern of T‐cell receptor gene rearrangements was detected. These findings indicate that both Ki‐1 positive anaplastic cells in the tumor and atypical lymphoid cells in the plaques were derived from the same T cell clone.
Drug Induced Acute Generalized Exanthematous Pustulosis
Authors: Katagiri Kazumoto , Takayasu Susumu 
Published: April 2015

AbstractA 62‐year‐old woman with diabetic triopathy developed widespread erythematous macules, numerous pustules, and a high fever after she underwent electric coagulation for vitreous hemorrhage. She was administered several drugs at that time. After discontinuation of the drugs, the eruption disappeared, and the fever returned to normal within two weeks. A positive patch test with isepamicin sulfate highly suggested that the symptoms described above were due to drug allergy. Cadralazine, which was positive in the drug lymphocyte stimulation test (DLST), could not be excluded from the causative drugs. A false‐positive DLST with ofloxacin was confirmed by an accidental challenge test. To our knowledge, this is the first report of acute generalized exanthematous pustulosis due to isepamicin sulfate and/or cadralazine.
A Case of Herpes Zoster Associated with Colitis
Authors: Okimura Hiroshi , Muto Masahiko , Ichimiya Makoto , Mogami Satoshi , Takahata Hiroaki , Asagami Chidori 
Published: April 2015

AbstractA 58‐year‐old Japanese woman who had herpes zoster in association with colitis was successfully treated with intravenously administrated acyclovir. Vesicular lesions with red haloes ranged from the left side of her buttock to the left extremity, corresponding to the L4 to S2 dermatomes. Her colitis was considered to have been induced by varicella‐zoster virus, based on the facts that the clinical courses were correlated and that the innervation of the affected site of the colon corresponded to an infected dermatome (S2).