bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Catalytic Electrophilic Halogenation of Silyl‐Protected and Terminal Alkynes: Trapping Gold(I) Acetylides vs. a Broensted Acid‐Promoted Reaction.
Authors: Starkov Pavel , Rota Filippo , D'Oyley Jarryl M. , Sheppard Tom D. 
Published: April 2013

AbstractTms‐protected acetylenes are halodesilylated by treatment with N‐halosuccinimide in the presence of a Broensted acid.
ChemInform Abstract: Highly Enantioselective Imine Hydrogenation Catalyzed by Ruthenium Phosphane—Phosphite Diamine Complexes.
Authors: Vaquero Monica , Suarez Andres , Vargas Sergio , Bottari Giovanni , Alvarez Eleuterio , Pizzano Antonio 
Published: April 2013

AbstractThe new ruthenium chloride (RUC) is found to be a highly efficient catalyst for the asymmetric hydrogenation of imines of type (I).
ChemInform Abstract: Discrete Iron Complexes for the Selective Catalytic Reduction of Aromatic, Aliphatic, and α,β‐Unsaturated Aldehydes under Water—Gas Shift Conditions.
Authors: Tlili Anis , Schranck Johannes , Neumann Helfried , Beller Matthias 
Published: April 2013

AbstractThe reaction can be run on a 10‐g‐scale.
ChemInform Abstract: Straightforward Heterogeneous Palladium Catalyzed Synthesis of Aryl Ethers and Aryl Amines via a Solvent Free Aerobic and Non‐Aerobic Dehydrogenative Arylation.
Authors: Sutter Marc , Sotto Nicolas , Raoul Yann , Metay Estelle , Lemaire Marc 
Published: April 2013

AbstractA novel process for the synthesis of functionalized aryl ethers by reaction of alcohols, polyols, substituted cyclohexanones or tetralones as substrates is described.
ChemInform Abstract: A Selective Palladium‐Catalyzed Carbonylative Arylation of Aryl Ketones to Give Vinylbenzoate Compounds.
Authors: Schranck Johannes , Tlili Anis , Neumann Helfried , Alsabeh Pamela G. , Stradiotto Mark , Beller Matthias 
Published: April 2013

AbstractIt provides a straightforward method to prepare (Z)‐vinylbenzoates.
ChemInform Abstract: A Highly Active Catalytic System for Suzuki—Miyaura Cross‐Coupling Reactions of Aryl and Heteroaryl Chlorides in Water.
Authors: Mao Shu‐Lan , Sun Yue , Yu Guang‐Ao , Zhao Cui , Han Zhi‐Jun , Yuan Jia , Zhu Xiaolei , Yang Qihua , Liu Sheng‐Hua 
Published: April 2013

AbstractA wide range of aromatic and heteroaromatic chlorides and some bromides, including hindered, activated and deactivated ones, are applied in the Suzuki—Miyaura cross‐coupling reaction in water to afford the products with moderate to high yields.
ChemInform Abstract: Ruthenium(II)‐Catalyzed Selective Monoarylation in Water and Sequential Functionalizations of C—H Bonds.
Authors: Arockiam Percia B. , Fischmeister Cedric , Bruneau Christian , Dixneuf Pierre H. 
Published: April 2013

AbstractThe selective ortho monoarylation of functional arenes (I), (IV), and (VI) directed by N‐containing heterocyclic groups is achieved using a Ru‐catalyst in water.
ChemInform Abstract: Enantioselective Intermolecular [2 + 2 + 2] Cycloadditions of Ene—Allenes with Allenoates.
Authors: Brusoe Andrew T. , Edwankar Rahul V. , Alexanian Erik J. 
Published: April 2013

AbstractThe title reaction leads to stereochemically complex carbocycles in a single step.
ChemInform Abstract: Tandem Cyclization of α‐Cyano α‐Alkynyl Aryl Ketones Induced by tert‐Butyl Hydroperoxide and Tetrabutylammonium Iodide.
Authors: Wong Ying‐Chieh , Tseng Chen‐Tso , Kao Tzu‐Ting , Yeh Yu‐Cheng , Shia Kak‐Shan 
Published: April 2013

AbstractVarious highly functionalized [6,6,5] tricyclic frameworks are obtained by the described new method.
ChemInform Abstract: Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor.
Authors: Tran Gael , Meier Robin , Harris Lawrence , Browne Duncan L. , Ley Steven V. 
Published: April 2013

AbstractA variety of trifluoromethylated heterocyclic building blocks is prepared using the readily available title compound (I).
ChemInform Abstract: Efficient Synthesis of Thieno[3,2‐b:4,5‐b′]diindoles and Benzothieno[3,2‐b]indoles by Pd‐Catalyzed Site‐Selective C—C and C—N Coupling Reactions.
Authors: Hung Tran Quang , Dang Tuan Thanh , Villinger Alexander , Sung Tran Van , Langer Peter 
Published: April 2013

AbstractThiophene‐containing pentacenes like compounds (VI) are of interest for materials science, e.
ChemInform Abstract: Dibenzo[a,c]carbazoles from 2‐(2‐Bromoaryl)‐3‐arylindoles via a Palladium‐Catalyzed Intramolecular C—H Functionalization/C—C Bond Formation Process.
Authors: Cacchi Sandro , Fabrizi Giancarlo , Goggiamani Antonella , Iazzetti Antonia 
Published: April 2013

AbstractThe present reaction provides a new versatile approach to dibenzo[a,c]‐carbazoles tolerating a variety of useful substituents.
ChemInform Abstract: Oxygen—Sulfur Rearrangement in the Reaction of Thiocarbamate Imidazolium Ylide with Arylaldehyde.
Authors: Zhao Yingwei , Lei Min , Yang Lei , Han Feng , Li Zhen , Xia Chungu 
Published: April 2013

AbstractThe ratio of the products (III) and (IV) depends on the used aldehyde and the reaction temperature.
ChemInform Abstract: Highly Regioselective Nitrile Oxide Dipolar Cycloadditions with ortho‐Nitrophenyl Alkynes.
Authors: McIntosh Melissa L. , Naffziger Michael R. , Ashburn Bradley O. , Zakharov Lev N. , Carter Rich G. 
Published: April 2013

AbstractFor the success of the title reaction the ortho‐nitro moiety and the sterically hindered mesityl group play an important role.
ChemInform Abstract: Efficient 2‐Aryl Benzothiazole Formation from Aryl Ketones and 2‐Aminobenzenethiols under Metal‐Free Conditions.
Authors: Liao Yunfeng , Qi Hongrui , Chen Shanping , Jiang Pengcheng , Zhou Wang , Deng Guo‐Jun 
Published: April 2013

AbstractVarious 2‐aryl benzothiazoles are selectively obtained by the present new method using molecular oxygen as oxidant.
ChemInform Abstract: Graphene‐Supported RuO2 Nanoparticles for Efficient Aerobic Cross‐Dehydrogenative Coupling Reaction in Water.
Authors: Meng Qing‐Yuan , Liu Qiang , Zhong Jian‐Ji , Zhang Hui‐Hui , Li Zhi‐Jun , Chen Bin , Tung Chen‐Ho , Wu Li‐Zhu 
Published: April 2013

AbstractTetrahydroisoquinolines undergo cross‐dehydrogenative coupling reactions with nitroalkanes under an oxygen atmosphere in water simply by using graphene‐supported RuO2 as the catalyst.
ChemInform Abstract: Natural α‐Amino Acids Applied in the Synthesis of Imidazo[1,5‐a]N‐heterocycles under Mild Conditions.
Authors: Wang Qiang , Zhang Shuai , Guo Fengfeng , Zhang Baiqun , Hu Ping , Wang Zhiyong 
Published: April 2013

AbstractThis is based on an iodine‐mediated decarboxylative cyclization.
ChemInform Abstract: Synthesis of Pyrazolo[5,1‐a]isoquinolines via Silver(I)—Rhodium(I) Cooperative Catalysis in the Reaction of N′‐(2‐Alkynylbenzylidene)hydrazide with Cycloprop‐2‐ene‐1,1‐dicarboxylate.
Authors: Yao Liangqing , Yu Xingxin , Mo Chen , Wu Jie 
Published: April 2013

AbstractThe reaction proceeds via consecutive 6‐endocyclization, [3 + 2] cycloaddition, cyclopropane ring opening and aromatization.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Novel 1,5‐Benzodiazepines.
Authors: Ilango S. S. , Remya P. U. , Ponnuswamy S. 
Published: April 2013

AbstractThe title compounds (III) are obtained by CdCl2‐catalyzed reaction of acetoacetanilides with o‐phenylenediamine under conventional heating as well as microwave irradiation conditions.
ChemInform Abstract: Cinchona Alkaloid Amides/Dialkylzinc Catalyzed Enantioselective Desymmetrization of Aziridines with Phosphites.
Authors: Hayashi Masashi , Shiomi Noriyuki , Funahashi Yasuhiro , Nakamura Shuichi 
Published: April 2013

AbstractThis is the first highly enantioselective desymmetrization of aziridines with phosphites yielding β‐aminophosphonates.
ChemInform Abstract: A Simple and Stereoselective Synthesis of (Z)‐1,2‐Bis‐arylselanyl Alkenes from Alkynes Using KF/Al2O3.
Authors: Lara Renata G. , Rosa Paloma C. , Soares Liane K. , Silva Marcio S. , Jacob Raquel G. , Perin Gelson 
Published: April 2013

AbstractHowever, the reaction of phenylacetylene with dimesityl diselenide only provides the alkynyl selenide (IV).
ChemInform Abstract: Synthesis and Z/E Isomerization of 2‐Imino‐1,3‐thiaselenolanes via Iodocyclization.
Authors: Toyoda Yosuke , Koketsu Mamoru 
Published: April 2013

AbstractTreatment of isoselenocyanates with allyl mercaptan followed by I2‐ or HCl‐mediated cyclization results in formation of new 2‐imino‐1,3‐thiaselenolanes.
ChemInform Abstract: anti‐Angiogenesis and Immunomodulatory Activities of an Antitumor Sesquiterpene Bigelovin Isolated from Inula helianthus‐aquatica.
Authors: Tan Ning‐Hua , et al. et al. 
Published: April 2013

AbstractTitle compound Bigelovin (I*) may exert multi‐target functions against cancer in animal models.
ChemInform Abstract: Cytotoxic Quassinoids from Ailanthus altissima.
Authors: Zhang Xiao‐Qi , et al. et al. , et al. et al. 
Published: April 2013

AbstractTwo new quassinoids, altissinol A (I) and B (II), are isolated along with 12 known quassinoids from the barks of Ailanthus altissima.
ChemInform Abstract: A New Phenylpentanamine Alkaloid Produced by an Endophyte Bacillus subtillis Isolated from Angelica sinensis
Authors: Yang Nian‐Yun , Jiang Shu , Shang Er‐Xin , Tang Yu‐Ping , Duan Jin‐Ao 
Published: April 2013

Abstractisolation and structure determination
ChemInform Abstract: anti‐Liver Fibrotic Lignans from the Fruits of Schisandra arisanensis and Schisandra sphenanthera.
Authors: Shen Ya‐Ching , et al. et al. 
Published: April 2013

AbstractThree new polyoxygenated C18‐dibenzocyclooctadiene lignans, arisanschinins M (I) and N (II), and schisphenin A (III) are isolated along with eight related metabolites from the fruits of Schisandra arisanenis and Schisandra sphenanthera, respectively.
ChemInform Abstract: Molecular Alliance — From Orthosteric and Allosteric Ligands to Dualsteric/Bitopic Agonistst at G Protein Coupled Receptors
Authors: Mohr Klaus , Schmitz Jens , Schrage Ramona , Traenkle Christian , Holzgrabe Ulrike 
Published: April 2013

AbstractReview: 53 refs.
Public‐key encryption scheme with selective opening chosen‐ciphertext security based on the Decisional Diffie–Hellman assumption
Authors: Liu Shengli , Zhang Fangguo , Chen Kefei 
Published: April 2013

SUMMARYChosen‐ciphertext security has been well‐accepted as a standard security notion for public‐key encryption. But in a multi‐user surrounding, it may not be sufficient, because the adversary may corrupt some users to obtain the random coins as well as the plaintexts used to generate ciphertexts. The attack is named ‘selective opening attack’. We study how to achieve full‐fledged chosen‐ciphertext security in selective opening setting directly from the Decisional Diffie–Hellman assumption. Our construction is actually a tag‐based public‐key encryption scheme free of chameleon hashing and has a tight security reduction to the Decisional Diffie–Hellman assumption and the collision‐resistant assumption of hash functions. The tag for each ciphertext is generated in a flexible way to serve the chosen‐ciphertext security proof in selective opening settings. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis, Crystal Structures and Properties of the First Lanthanum Selenide Chlorides, LaSeCl and La3Se4Cl
Authors: Schurz Christian M. , Frunder Susanne , Schleid Thomas 
Published: April 2013

AbstractThe first two lanthanum selenide chlorides, LaSeCl and La3Se4Cl, both crystallize orthorhombically in space group Pnma (no. 62). They emerged from reactions of LaCl3 with lanthanum and selenium in appropriate molar ratios at 800–900 °C. Single crystals of the yellow LaSeCl adopt the cotunnite‐type structure of PbCl2 with a = 760.63(5), b = 433.52(3) and c = 910.07(6) pm (Z = 4). The tricapped trigonal prisms [LaSe5Cl4]11– share their triangular faces to form chains that run parallel to the [010] direction and are condensed through caps and common edges to give a complete crystal structure in accord with ∞3{LaSe5/5Cl4/4}. Dark‐red La3Se4Cl exhibits the U3S5‐type structure with a = 1271.98(5), b = 855.84(3) and c = 795.05(2) pm (Z = 4). The chloride anions are located at the Wyckoff position 8d together with selenium showing site occupation factors of 0.5 for both anion types. Bicapped trigonal prisms [LaSe7Cl]12– with (La2)3+ are connected through common faces and corners to form a three‐dimensional framework suited to the embedding of chains of fused tricapped trigonal prisms [LaSe5+1Cl2]11– with (La1)3+ running parallel to [010]. The absorption edge energy of approximately 1.75 eV indicates a wide band‐gap semiconductor that is stable towards air, water and some aqueous bases at different concentrations.
One‐Pot Synthesis of Heteroaryl and Diheteroaryl Ketones through Palladium‐Catalyzed 1,2‐Addition and Oxidation
Authors: Kuriyama Masami , Hamaguchi Norihisa , Sakata Keisuke , Onomura Osamu 
Published: April 2013

AbstractA synthetic method was developed for the preparation of heteroaryl and diheteroaryl ketones from aldehydes and organoboronic acids through a palladium‐catalyzed 1,2‐addition and oxidation that uses an aryl iodide as the oxidant. This one‐pot process shows high tolerance for a broad range of heterocyclic substrates by using 1.0–3.0 mol‐% of the catalyst that is formed from allylpalladium chloride dimer and a thioether‐imidazolinium chloride. In addition to fine‐tuning the catalytic system, the use of a sterically hindered aryl iodide that has a substituent at the ortho position, such as 2‐iodotoluene, is important to obtain the desired ketones with heterocyclic moieties in good to excellent yields.
Genetic characterization of selected parasites from people with histories of gastrointestinal disorders using a mutation scanning‐coupled approach
Authors: Koehler Anson V. , Bradbury Richard S. , Stevens Melita A. , Haydon Shane R. , Jex Aaron R. , Gasser Robin B. 
Published: April 2013

A SSCP analysis and targeted sequencing approach was used for the genetic characterization of some major pathogens from a cohort of 227 people with histories of gastrointestinal disorders. Genomic DNAs from fecal samples were subjected to PCR‐amplification of regions in the glycoprotein (gp60) or triose phosphate isomerase (tpi) gene, or the second internal transcribed spacer of nuclear ribosomal DNA (ITS‐2). Cryptosporidium, Giardia, and strongylid nematodes were detected in 94, 132 and 12 samples. Cryptosporidium hominis subgenotypes IbA10G2, IdA15G1, IgA17, IgA18, and IfA13G1 were identified in 74.6, 16.9, 5.6, 1.4, and 1.4% of 71 samples, respectively. For Cryptosporidium parvum, subgenotypes IIaA17G2R1 (47.6%) and IIaA18G3R1 (23.8%) were identified in 23 samples. Giardia duodenalis assemblage B (78%) was more common than assemblage A (22%). In addition, DNA of the nematodes Ancylostoma ceylanicum (n = 2), Ancylostoma duodenale (4), Necator americanus (5), and Haemonchus contortus (1) was specifically detected. This is the first report of A. ceylanicum in two persons in Australia and, we provide molecular evidence of H. contortus in a child. This SSCP‐based approach should provide a useful diagnostic and analytical tool for a wide range of pathogens.
The internal concentration of organic substances in fish embryos—A toxicokinetic approach
Authors: Kühnert Agnes , Vogs Carolina , Altenburger Rolf , Küster Eberhard 
Published: April 2013

Abstract

In ecotoxicity assessment, the ambient exposure concentration is typically applied to quantify the toxic potential of xenobiotic substances. However, exposure and organism-related differences in bioconcentration often cause a considerable variability of toxicity data. This can be minimized by using the internal organism concentration, because toxicokinetic modifying factors are considered implicitly. In the present study, the relationship between ambient and internal concentration–time profiles was investigated for zebrafish (Danio rerio) embryos. The aim was to gain a better understanding and interpretation of exposure-based methods using this model organism. For this purpose, a simple and effective approach to determine the internal concentration was developed. Embryos were exposed to a series of 4 neutral organic substances (naphthalene, fluorene, fluoranthene, benz[a]anthracene) of different hydrophobicity for 72 h. The internal and ambient concentrations were measured at 8 to 9 time points. Kinetics of uptake and elimination were modeled using a first-order 1-compartment model. Biotransformation processes appeared to influence the internal concentrations of fluoranthene and benz[a]anthracene after 48 h. The bioconcentration factors (BCFs) obtained are in excellent agreement with those determined in previous studies using radiolabeled substances. The method demonstrated in the present study is a further step toward a refined ecotoxicity assessment using fish embryos, which links toxicity to the chemical concentration within the organism. This system may also be considered as an alternative to animal testing for BCF determination. Environ Toxicol Chem 2013;32:1819–1827. © 2013 SETAC
Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions
Authors: Connors Kristin A. , Du Bowen , Fitzsimmons Patrick N. , Hoffman Alex D. , Chambliss C. Kevin , Nichols John W. , Brooks Bryan W. 
Published: April 2013

Abstract

The occurrence of pharmaceuticals in the environment presents a challenge of growing concern. In contrast to many industrial compounds, pharmaceuticals undergo extensive testing prior to their introduction to the environment. In principle, therefore, it may be possible to employ existing pharmacological safety data using biological “read-across” methods to support screening-level bioaccumulation environmental risk assessment. However, few approaches and robust empirical data sets exist, particularly for comparative pharmacokinetic applications. For many pharmaceuticals, the primary cytochrome P450 (CYP) enzymes responsible for their metabolism have been identified in humans. The purpose of the present study was to employ a comparative approach to determine whether rainbow trout biotransform pharmaceuticals known to be substrates for specific human CYPs. Seven compounds were selected based on their primary metabolism in humans by CYP3A4, CYP2D6, or CYP2C9. Five additional test compounds are known to be substrates for multiple CYPs. Metabolism by rainbow trout liver S9 fractions was evaluated using a substrate-depletion approach, which provided an estimate of intrinsic hepatic clearance (CLIN VITRO,INT). An isotope dilution liquid chromatography–tandem mass spectrometry method was employed for quantitation of parent chemical concentrations. Only 2 general CYP substrates demonstrated measurable levels of substrate depletion. No significant biotransformation was observed for known substrates of human CYP2D6, CYP2C9, or CYP3A4. The results of this study provide novel information for therapeutics that fish models are likely to metabolize based on existing mammalian data. Further, these results suggest that pharmaceuticals may possess a greater tendency to bioaccumulate in fish than previously anticipated. Environ Toxicol Chem 2013;32:1810–1818. © 2013 SETAC
Performance of passive samplers for monitoring estuarine water column concentrations: 2. Emerging contaminants
Authors: Perron Monique M. , Burgess Robert M. , Suuberg Eric M. , Cantwell Mark G. , Pennell Kelly G. 
Published: April 2013

Abstract

Measuring dissolved concentrations of emerging contaminants, such as polybrominated diphenyl ethers (PBDEs) and triclosan, can be challenging due to their physicochemical properties resulting in low aqueous solubilities and association with particles. Passive sampling methods have been applied to assess dissolved concentrations in water and sediments primarily for legacy contaminants. Although the technology is applicable to some emerging contaminants, the use of passive samplers with emerging contaminants is limited. In the present study, the performance of 3 common passive samplers was evaluated for sampling PBDEs and triclosan. Passive sampling polymers included low-density polyethylene (PE) and polyoxymethylene (POM) sheets, and polydimethylsiloxane (PDMS)-coated solid-phase microextraction (SPME) fibers. Dissolved concentrations were calculated using measured sampler concentrations and laboratory-derived partition coefficients. Dissolved tri-, tetra-, and pentabrominated PBDE congeners were detected at several of the study sites at very low pg/L concentrations using PE and POM. Calculated dissolved water concentrations of triclosan ranged from 1.7 ng/L to 18 ng/L for POM and 8.8 ng/L to 13 ng/L for PE using performance reference compound equilibrium adjustments. Concentrations in SPME were not reported due to lack of detectable chemical in the PDMS polymer deployed. Although both PE and POM were found to effectively accumulate emerging contaminants from the water column, further research is needed to determine their utility as passive sampling devices for emerging contaminants. Environ Toxicol Chem 2013;32:2190–2196. © 2013 SETAC
Preferences and utilities for health states after treatment for oropharyngeal cancer: Transoral robotic surgery versus definitive (chemo)radiotherapy
Authors: de Almeida John R. , Villanueva Nathaniel L. , Moskowitz Alan J. , Miles Brett A. , Teng Marita S. , Sikora Andrew , Gupta Vishal , Posner Marshall , Genden Eric M. 
Published: April 2013

BackgroundTreatment of oropharyngeal cancer with transoral robotic surgery (TORS) or definitive (chemo)radiotherapy impacts quality of life. Utility scores are needed for quality of life and economic comparisons.MethodsFifty healthy subjects and 9 experts reviewed scenarios describing treatment (TORS alone or with adjuvant radiotherapy or chemoradiotherapy [CRT], definitive radiotherapy, and CRT), complications, remission, and recurrences. Utilities were assessed using visual analog scale (VAS) and standard gamble (SG) techniques. Treatments were compared using paired comparisons and demographic variability was assessed.ResultsTORS had higher SG utilities than radiotherapy (p= .001) and CRT (p< .001) and was preferred in paired comparisons (p< .001 for both) for healthy subjects. Utilities did not vary by demographic group and correlated between experts and subjects (VASr= 0.95;p< .001; SGr= 0.97;p< .001).ConclusionTORS has higher utility scores than CRT. Utilities can be used for cost–utility analyses. © 2014 Wiley Periodicals, Inc. Head Neck 36: 923–933, 2014
Unusual metastases from tall cell variant of papillary thyroid cancer
Authors: Pagano Loredana , Caputo Marina , Samà Maria Teresa , Zavattaro Marco , Prodam Flavia , Mauri Maria Grazia , Pia Francesco , Alonzo Amedeo , Valente Guido , Aimaretti Gianluca 
Published: April 2013

BackgroundTall cell variant (TCV) cancer is considered more aggressive than the classic variant of papillary thyroid cancer (PTC). Distant metastases are more common among this variant and affect survival. Little is known about the molecular pattern of this histotype.MethodsThis is a report of 2 cases of unusual metastases from TCV, BRAF V600E‐positive.ResultsA 38‐year‐old woman developed subcutaneous metastases during short‐term follow‐up; at medium‐term follow‐up, the patient showed detectable stimulated serum thyroglobulin without disease evidence at imaging. A 33‐year‐old man presented incidental thymic metastases at time of surgical treatment; this is the first case of not ectopic thymic metastases from PTC.ConclusionTCV may present with unusual metastases already during early follow‐up. The more aggressive behavior could be linked to the higher prevalence of BRAF point mutations, but only a long‐term follow‐up might clarify if this association could worsen the prognosis. Moreover, skin metastases have been predictive factors of worse outcome in our patients, but not thymic metastases. © 2013 Wiley Periodicals, Inc. Head Neck 35: E381–E385, 2013