bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the use of immersive virtual reality in adults with chronic primary pain: A scoping review
Authors: Astek Anfal , Sparkes Valerie , Sheeran Liba 
Published: August 2024

Background The use of immersive virtual reality, wearing head mounted display, has recently increased for people with chronic pain, with no definitive conclusion of its efficacy on pain-related outcomes. Objective To map the available evidence on the use of immersive virtual reality as intervention for adults with chronic primary pain, illustrating gap in knowledge and direct future research. Methods The search was performed with a range of study designs, but only those written in English language. A search was created in CINAHL Plus, Medline, AMED, Embase, PsycINFO, ASSIA, Scopus, TripPro, CENTRAL and EmCare. Results Thirty-two studies were included. Several chronic conditions were identified including chronic musculoskeletal pain and fibromyalgia. The immersive virtual reality mechanisms included distraction, physical exercises, mindfulness/biofeedback, graded exposure, hypnosis, neuromodulation, and multi-mechanisms, and all these mechanisms were associated with varied dose. The use of customised software, with wide range of head mounted displays were common in clinical setting with some degree of supervision. Motion sickness, head mounted display discomfort and technical issues affect the usability of immersive virtual reality leading to poor engagement and dropouts. Conclusions The use of immersive virtual reality for chronic primary pain is in early stages with lack of consensus regarding the mechanisms and associated dose. Future research needs to address the need of customisation, clinical usability of head mounted display as well as safety strategies to enhance the uptake of immersive virtual reality technology in healthcare practice.
Relaxation training via tele-rehabilitation program in patients with breast cancer receiving chemotherapy during COVID-19
Authors: Bahçaci Umut , Uysal Songül Atasavun , Namal Esat 
Published: August 2024

Introduction The COVID-19 pandemic has highlighted the significance of tele-rehabilitation in granting access to physical therapy for breast cancer patients. To mitigate the adverse effects of chemotherapy, Jacobson's relaxation techniques can be performed from the comfort and safety of patients’ homes. The aim of this research was to investigate the effects of relaxation exercises delivered via tele-rehabilitation in breast cancer patients receiving chemotherapy. Method A total of 64 patients, were randomly allocated to the exercise group ( n = 33) and to the control group ( n = 31). The exercise group performed supervised “Jacobson Progressive Relaxation” exercises in groups of up to eight participants, three times a week for 6 weeks via WhatsApp© meetings. The control group was provided with a simple relaxation exercise brochure. The primary outcome was the “pain” which was measured by “Brief Pain Inventory.” Fatigue, emotional state, quality of life, cognitive state, sleep quality, and kinesiophobia were considered as secondary outcomes. All measurements were made at the first appointment and after the intervention. Results The study was finally completed with 52 participants, 26 in each group. The exercise group demonstrated a statistically significant improvement in pain (all subscales p < 0.05), quality of life (symptom scale p = 0.006), cognitive function (perceived cognitive impairment p = 0.009), and (total p = 0.016) subscales, sleep quality ( p < 0.001), emotional state (depression p = 0.007, anxiety p = 0.003), and fatigue scores ( p = 0.017) compared to the control group in the score change before and after the intervention. No significant difference was found between the groups in terms of kinesiophobia scores ( p > 0.05). Within-group results exhibited improvement across various measures in both groups, with statistical significance ( p < 0.05). Discussion The effectiveness of telerehabilitation-based progressive relaxation exercises in improving the pain, quality of life, cognitive status, sleep quality, anxiety–depression, and fatigue levels experienced by breast cancer patients undergoing taxane chemotherapy has been demonstrated in this study.
Reasoning about self and others: A dynamic process
Authors: Geveke C H , Veenker H J J M , Steenbeek H W 
Published: August 2024

Background It can be very challenging for practitioners to talk with autistic children, especially when the conversation calls for self-regulation. Self-regulation is inextricably linked to awareness of oneself and others in social contexts. Encouraging the need for autonomy could help increase self-awareness and awareness of others in social events, which in turn could strengthen self-regulation. However, little is known about how autonomy influences competence in reasoning about self and others when regarding social events in which autistic children participate. This study explores the reasoning of self-other awareness on a microlevel timescale using ipsative, dynamic approaches to autism. The central question in this study is: to what extent can autonomy-provided scaffolding (APS) elicit high levels of reasoning about self-others in social events (RSS) over time? Method We used video-taped interaction data from three sessions between one autistic child and a practitioner, contextualized by a set of animated DSM-5-based items of social events on which the child was asked to reflect. Interaction variables were the child's level of RSS and the practitioner's level of APS. We coded the real-time interaction. Results First, when exploring the dynamics of the microdata, we found contingency over time within sessions. Second, over the sessions, the practitioner showed a stable high level of APS, whereas the child's level of RSS increased. Third, a coupling effect between the level of APS and RSS was found within and over sessions. Salient is that the child and practitioner increasingly adapted to each other over the three sessions, and over time, high-level APS of the practitioner elicited higher levels of RSS of the child. Discussion Because the child showed a significant improvement in RSS over time, our research question provides a promising perspective. Contrary to what one might expect in autism, APS supported the performance of the child in reasoning about self-others in social situations. These outcomes underline the importance of giving voice to autistic children. The results may encourage researchers to develop strategies and tools that can help give a voice to children, to gain more insight into the child's reasoning. This may further develop self-other awareness and self-regulation in the social events of autistic children.
Numerical Prediction of Ride Comfort of Tracked Vehicle Equipped with Novel Flexible Road Wheels
Authors: Deng Yaoji , Wang Zhiyue , Zhao Youqun , Gong Junjie , Shen Hui , Lin Fen 
Published: August 2024

AbstractEnhancing ride comfort has always constituted a crucial focus in the design and research of modern tracked vehicles, heavily reliant on the driving system’s performance. While the road wheel is a key component of the driving system, traditional road wheels predominantly adopt a solid structure, exhibiting subpar adhesion performance and damping effects, thereby falling short of meeting the demands for high-speed, stable, and long-distance driving in tracked vehicles. Addressing this issue, this paper proposes a novel type of flexible road wheel (FRW) characterized by a catenary construction. The study investigates the ride comfort of tracked vehicles equipped with flexible road wheels by integrating finite element and vehicle dynamic. First, three-dimensional (3D) finite element (FE) models of both flexible and rigid road wheels are established, considering material and contact nonlinearities. These models are validated through a wheel radial loading test. Based on the validated FE model, the paper uncovers the relationship between load and radial deformation of the road wheel, forming the basis for a nonlinear mathematical model. Subsequently, a half-car model of a tracked vehicle with seven degrees of freedom is established using Newton’s second law. A random road model, considering the track effect and employing white noise, is constructed. The study concludes by examining the ride comfort of tracked vehicles equipped with flexible and rigid road wheels under various speeds and road grades. The results demonstrate that, in comparison to the rigid road wheel (RRW), the flexible road wheel enhances the ride comfort of tracked vehicles on randomly uneven roads. This research provides a theoretical foundation for the implementation of flexible road wheels in tracked vehicles.
Stomatal penetration: the cornerstone of plant resistance to the fungal pathogen Zymoseptoria tritici
Authors: Battache Mélissa , Suarez-Fernandez Marta , Klooster Madison Van’t , Cambon Florence , Sánchez-Vallet Andrea , Lebrun Marc-Henri , Langin Thierry , Saintenac Cyrille 
Published: August 2024

Abstract
Background
Septoria tritici blotch (STB), caused by the foliar fungus Zymoseptoria tritici, is one of the most damaging disease of wheat in Europe. Genetic resistance against this fungus relies on different types of resistance from non-host resistance (NHR) and host species specific resistance (HSSR) to host resistance mediated by quantitative trait loci (QTLs) or major resistance genes (Stb). Characterizing the diversity of theses resistances is of great importance for breeding wheat cultivars with efficient and durable resistance. While the functional mechanisms underlying these resistance types are not well understood, increasing piece of evidence suggest that fungus stomatal penetration and early establishment in the apoplast are both crucial for the outcome of some interactions between Z. tritici and plants. To validate and extend these previous observations, we conducted quantitative comparative phenotypical and cytological analyses of the infection process corresponding to 22 different interactions between plant species and Z. tritici isolates. These interactions included four major bread wheat Stb genes, four bread wheat accessions with contrasting quantitative resistance, two species resistant to Z. tritici isolates from bread wheat (HSSR) and four plant species resistant to all Z. tritici isolates (NHR).

Results
Infiltration of Z. tritici spores into plant leaves allowed the partial bypass of all bread wheat resistances and durum wheat resistance, but not resistances from other plants species. Quantitative comparative cytological analysis showed that in the non-grass plant Nicotiana benthamiana, Z. tritici was stopped before stomatal penetration. By contrast, in all resistant grass plants, Z. tritici was stopped, at least partly, during stomatal penetration. The intensity of this early plant control process varied depending on resistance types, quantitative resistances being the least effective. These analyses also demonstrated that Stb-mediated resistances, HSSR and NHR, but not quantitative resistances, relied on the strong growth inhibition of the few Z. tritici penetrating hyphae at their entry point in the sub-stomatal cavity.

Conclusions
In addition to furnishing a robust quantitative cytological assessment system, our study uncovered three stopping patterns of Z. tritici by plant resistances. Stomatal resistance was found important for most resistances to Z. tritici, independently of its type (Stb, HSSR, NHR). These results provided a basis for the functional analysis of wheat resistance to Z. tritici and its improvement.
Identification of potential biomarkers for atrial fibrillation and stable coronary artery disease based on WGCNA and machine algorithms
Authors: Wu Ke , Chen Hao , Li Fan , Meng Xiangjuan , Chen Lin , Li Nannan 
Published: August 2024

Abstract
Background
Patients with atrial fibrillation (AF) often have coronary artery disease (CAD), but the biological link between them remains unclear. This study aims to explore the common pathogenesis of AF and CAD and identify common biomarkers.

Methods
Gene expression profiles for AF and stable CAD were downloaded from the Gene Expression Omnibus database. Overlapping genes related to both diseases were identified using weighted gene co-expression network analysis (WGCNA), followed by functional enrichment analysis. Hub genes were then identified using the machine learning algorithm. Immune cell infiltration and correlations with hub genes were explored, followed by drug predictions. Hub gene expression in AF and CAD patients was validated by real-time qPCR.

Results
We obtained 28 common overlapping genes in AF and stable CAD, mainly enriched in the PI3K-Akt, ECM-receptor interaction, and relaxin signaling pathway. Two hub genes, COL6A3 and FKBP10, were positively correlated with the abundance of MDSC, plasmacytoid dendritic cells, and regulatory T cells in AF and negatively correlated with the abundance of CD56dim natural killer cells in CAD. The AUCs of COL6A3 and FKBP10 were all above or close to 0.7. Drug prediction suggested that collagenase clostridium histolyticum and ocriplasmin, which target COL6A3, may be potential drugs for AF and stable CAD. Additionally, COL6A3 and FKBP10 were upregulated in patients with AF and CAD.

Conclusion
COL6A3 and FKBP10 may be key biomarkers for AF and CAD, providing new insights into the diagnosis and treatment of this disease.
Interactive molecular causal networks of hypertension using a fast machine learning algorithm MRdualPC
Authors: Kelly Jack , Xu Xiaoguang , Eales James M. , Keavney Bernard , Berzuini Carlo , Tomaszewski Maciej , Guo Hui 
Published: August 2024

Abstract
Background
Understanding the complex interactions between genes and their causal effects on diseases is crucial for developing targeted treatments and gaining insight into biological mechanisms. However, the analysis of molecular networks, especially in the context of high-dimensional data, presents significant challenges.

Methods
This study introduces MRdualPC, a computationally tractable algorithm based on the MRPC approach, to infer large-scale causal molecular networks. We apply MRdualPC to investigate the upstream causal transcriptomics influencing hypertension using a comprehensive dataset of kidney genome and transcriptome data.

Results
Our algorithm proves to be 100 times faster than MRPC on average in identifying transcriptomics drivers of hypertension. Through clustering, we identify 63 modules with causal driver genes, including 17 modules with extensive causal networks. Notably, we find that genes within one of the causal networks are associated with the electron transport chain and oxidative phosphorylation, previously linked to hypertension. Moreover, the identified causal ancestor genes show an over-representation of blood pressure-related genes.

Conclusions
MRdualPC has the potential for broader applications beyond gene expression data, including multi-omics integration. While there are limitations, such as the need for clustering in large gene expression datasets, our study represents a significant advancement in building causal molecular networks, offering researchers a valuable tool for analyzing big data and investigating complex diseases.
Real-world dosing of regorafenib and outcomes among patients with metastatic colorectal cancer: a retrospective analysis using US claims data
Authors: Bekaii-Saab Tanios , Khan Nasreen , Ostojic Helene , Jiao XiaoLong , Chen Guifang , Lin Wenlong , Bruno Amanda 
Published: August 2024

Abstract
Background
The randomized, dose-optimization, open-label ReDOS study in US patients with metastatic colorectal cancer (CRC) showed that, compared with a standard dosing approach, initiating regorafenib at 80 mg/day and escalating to 160 mg/day depending on tolerability increased the proportion of patients reaching their third treatment cycle and reduced the incidence of adverse events without compromising efficacy. Subsequently, the ReDOS dose-escalation strategy was included as an alternative regorafenib dosing option in the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines. A retrospective analysis was conducted using a US claims database to assess whether inclusion of this dose-escalation strategy in NCCN Guidelines has influenced the use of flexible dosing in routine US clinical practice, and to describe clinical outcomes pre- and post-inclusion in NCCN Guidelines.

Methods
Patients with CRC in the Optum’s de-identified Clinformatics® Data Mart database initiating regorafenib for the first time between January 2016 and June 2020 were stratified based on whether they initiated regorafenib pre- or post-inclusion of ReDOS in NCCN Guidelines, and in two groups: flexible dosing (< 160 mg/day; < 84 tablets in the first treatment cycle) and standard dosing (160 mg/day; ≥ 84 tablets in the first treatment cycle). The primary endpoints were the proportion of patients who initiated their third treatment cycle and the mean number of treatment cycles per group.

Results
703 patients initiated regorafenib during the study period, of whom 310 (44%) initiated before and 393 (56%) initiated after inclusion of ReDOS in NCCN Guidelines. After inclusion in the guidelines, the proportion of patients who received flexible dosing increased from 21% (n = 66/310) to 45% (n = 178/393), the proportion who received standard dosing decreased from 79% (n = 244/310) to 55% (n = 215/393), the proportion who initiated their third treatment cycle increased from 36% (n = 113/310) to 46% (n = 179/393), and the mean (standard deviation) number of treatment cycles increased from 2.6 (2.9) to 3.2 (3.1).

Conclusions
Following inclusion of ReDOS in NCCN Guidelines, real-world data suggest that US clinicians have markedly increased use of flexible dosing in clinical practice, potentially maximizing clinical benefits and safety outcomes for patients with metastatic CRC receiving regorafenib.
Methods and participant characteristics in the Cancer Risk in Vegetarians Consortium: a cross-sectional analysis across 11 prospective studies
Authors: Dunneram Yashvee , Lee Jia Yi , Watling Cody Z. , Fraser Gary E. , Miles Fayth , Prabhakaran Dorairaj , Shridhar Krithiga , Kondal Dimple , Mohan Viswanathan , Ali Mohammed K. , Narayan Kabayam M. Venkat , Tandon Nikhil , Tong Tammy Y. N. , Chiu Tina H. T. , Lin Ming-Nan , Lin Chin-Lon , Yang Hsin-Chou , Liang Yu-Jen , Greenwood Darren C. , Du Huaidong , Chen Zhengming , Yu Canqing , Kakkoura Maria G. , Reeves Gillian K. , Papier Keren , Floud Sarah , Sinha Rashmi , Liao Linda M. , Loftfield Erikka , Cade Janet E. , Key Timothy J. , Perez-Cornago Aurora 
Published: August 2024

Abstract

Background
The associations of vegetarian diets with risks for site-specific cancers have not been estimated reliably due to the low number of vegetarians in previous studies. Therefore, the Cancer Risk in Vegetarians Consortium was established. The aim is to describe and compare the baseline characteristics between non-vegetarian and vegetarian diet groups and between the collaborating studies.

Methods
We harmonised individual-level data from 11 prospective cohort studies from Western Europe, North America, South Asia and East Asia. Comparisons of food intakes, sociodemographic and lifestyle factors were made between diet groups and between cohorts using descriptive statistics.

Results
2.3 million participants were included; 66% women and 34% men, with mean ages at recruitment of 57 (SD: 7.8) and 57 (8.6) years, respectively. There were 2.1 million meat eaters, 60,903 poultry eaters, 44,780 pescatarians, 81,165 vegetarians, and 14,167 vegans. Food intake differences between the diet groups varied across the cohorts; for example, fruit and vegetable intakes were generally higher in vegetarians than in meat eaters in all the cohorts except in China. BMI was generally lower in vegetarians, particularly vegans, except for the cohorts in India and China. In general, but with some exceptions, vegetarians were also more likely to be highly educated and physically active and less likely to smoke. In the available resurveys, stability of diet groups was high in all the cohorts except in China.

Conclusions
Food intakes and lifestyle factors of both non-vegetarians and vegetarians varied markedly across the individual cohorts, which may be due to differences in both culture and socioeconomic status, as well as differences in questionnaire design. Therefore, care is needed in the interpretation of the impacts of vegetarian diets on cancer risk.
A model of tertiary lymphatic structure-related prognosis for penile squamous cell carcinoma
Authors: Tang Han , Su Zhengwei , Huang Qingming , Li Yongpeng , Chen Rongchao , Ban Chengjie , Liu Chanzhen , Lu Haoyuan , Yi Xian-lin , Tang Yong 
Published: August 2024

Abstract
Background
We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC).

Methods
We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan–Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.

Result
BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835–0.932), and the decision consensus reached 0.581(0.508–0.655).

Conclusion
TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.