bluuebunny/crossref_metadata_2025_split huggingface dataset:
REVIEW: ACTIVITY OF DIOSGENIN COMPOUND AS ATHEROSCLEROSIS THERAPY
Authors: Rismawanti Rusi , Saidah Siti 
Published: June 2024

Atherosclerosis is a disease that causes inhibition of the stability of the cardiovascular system in the body. Cardiovascular disease remains at the top of the list of diseases that cause death. Therefore, cardiovascular disease therapy, including atherosclerosis, still needs to be developed to reduce the mortality rate associated with this disease. Several studies have shown that diosgenin compounds can be used as a therapy for atherosclerosis. The purpose of this study was to determine whether diosgenin compounds and their derivatives can be used for atherosclerosis therapy with various mechanisms of action related to the development of atherosclerosis. This article review was conducted using the article search method on Google Scholar, Pubmed, and Science Direct with various keywords. The results obtained are diosgenin and several diosgenin-derived compounds that can be used as therapies for atherosclerosis with several responses obtained from experiments using rats.
Keywords: diosgenin; atherosclerosis; diosgenin derivatives
EFFECTIVITY TEST OF THE COMBINATION OF ETHANOL EXTRACT MAHKOTA DEWA FRUIT (Phaleria macrocarpa (Scheff.) Boerl.) WITH METFORMIN TO LOWERING BLOOD GLUCOSE LEVELS IN ALLOXAN-INDUCED WISTAR WHITE RATS STRAIN
Authors: Widyanti Katarina Lulu , Sujono Tanti Azizah 
Published: June 2024

Metformin is a first-line biguanid drug for type 2 of diabetes mellitus. Metformin potentially causes liver fibrosis in long-term use, its decrease it in their effectiveness of antidiabetic. Combining metformin with antidiabetic a-glucosidase enzyme inhibitors can increase the effectiveness of metformin. Mahkota dewa fruit is a natural ingredient that has antidiabetic activity with the mechanism of action of inhibiting a-glucosidase enzyme.
This study aims to determine the effect of the combination of mahkota dewa fruit extract (EEMF) with metformin on the effectiveness of reducing blood glucose levels in diabetic rats. A total of 20 rats were grouped into 4, namely, group I: given distilled water (negative control); group II: given metformin 45 mg/kgBW; group III: given EEMF 50 mg/kgBW; group IV: given a combination of metformin 45 mg/kgBW and EEMF 50 mg/kgBW. The study was conducted by determining blood glucose levels using the GOD-PAP method. The results showed that the combination of EEMF with metformin had an average decrease per day from after induction to day 7 of 42,9 mg/dL and from day 7 to day 14 of 0,45 mg/dL. It can be concluded that the combination of EEMF dose 50 mg/kgBW with metformin 45 mg/kgBW is not recommended to be used together, because the large decrease has the risk of hypoglycemia effect.
Keywords: antidiabetic, alloxan, metformin, fruit of mahkota dewa.
FORMULATION AND EFFICACY TESTING OF SPF (Sun Protecting Factor) SUNSCREEN GEL EXTRACT OF RAMBUSA LEAVES (Passiflora Foetida L)
Authors: Hasanah Fauziyyah Al , Rabbaniyyah Muthi’ah , Kurniati Eni 
Published: June 2024

The rambusa plant contains flavonoid compounds found in rambusa leaves which are good antioxidants because they have hydroxyl groups attached to aromatic carbon rings. This makes rambusa leaves able to ward off free radicals. The choice of gel composition is based on practical considerations because gel not only provides effective protection against sunlight but also has non-sticky properties, provides a soft feel and forms a film that adheres well to the skin. This research aims to determine the flavonoid content in rambusa leaves, which are antioxidants that can be formulated into sunscreen gel preparations to help protect the skin from sunlight. Determination of antioxidant levels in sunscreen gel preparations made from rambusa leaf extract was carried out by measuring the SPF (Sun Protection Factor) value at three different concentrations, namely 2%, 4%, and 6% using UV-Vis spectroscopy. The research results showed that all formulas had good physical quality values of the gel preparations. All formulas have varying SPF values, where the 2% concentration has maximum protection with an SPF value of 11.7 and the 4% and 6% concentrations have ultra protection with SPF values of 18.8 and 33.9. The conclusion of this research is that rambusa leaf extract has the potential to be an effective natural ingredient in sunscreen preparations and shows the ability to protect the skin from sunlight, where formulation 3 only has the highest SPF number, namely 33.90 (super protection).
Keywords: Rambusa leaves, Protection, Sunscreen, SPF
Les imaginaires de l’enseignement et de l’apprentissage des langues dans trois romans de science-fiction dystopiques
Authors: Jingand Alexia 
Published: June 2024

À partir d’un corpus dystopique trilingue (anglais, français, allemand), cet article explore les imaginaires de la didactique des langues. Dans la traduction du roman américain Les Langages de Pao (Vance, 1958), le roman de l’Algérien francophone 2084 : la fin du monde (Sansal, 2015) et le roman est-allemand non traduit à ce jour Das kugeltranszendentale Vorhaben (Braun et Braun, 1983), des personnages d’enseignants et d’apprenants des langues présentent des récurrences des représentations métadidactiques qu’il s’agit de définir et de catégoriser. L’analyse du contenu fondée sur des éléments paradigmatiques et syntagmatiques (Dufays, 2010) s’intéresse aux dimensions lexico-pragmatiques de l’expression des imaginaires relatifs à l’enseignement des langues (quelles langues apprend-on, comment sont formés les enseignants, en quoi la profession est-elle institutionnalisée et prestigieuse ?) et à l’apprentissage des langues (l’élève est-il un prisonnier du professeur, quel rôle joue le relativisme linguistique dans l’apprentissage et comment est mis en scène l’apprentissage informel ?). Cette lecture aboutit à une proposition de modélisation des imaginaires hiérarchisés métadidactiques dans les romans de science-fiction dystopique à partir des attitudes métadidactiques, des contenus d’enseignement/apprentissage, des acteurs de la relation didactique, des conditions matérielles et de l’attitude sociale qui en émerge.
Enseigner la science-fiction
Authors: Gunn James 
Published: June 2024

L’article explore les complexités de l’enseignement de la science-fiction dans les milieux académiques. L’auteur note que de nombreux cours de science-fiction se concentrent sur ces thèmes plutôt que sur le genre lui-même, en partie à cause des difficultés à obtenir l’accord de l’administration et en partie à cause de la difficulté à enseigner la science-fiction comme un genre distinct. Gunn plaide pour une enquête approfondie des cours de science-fiction dans les lycées et les universités afin de mieux comprendre leur prévalence et leur contenu. S’appuyant sur sa vaste expérience d’enseignement à l’Université du Kansas, l’auteur décrit diverses approches de l’enseignement de la science-fiction, telles que la méthode des « grands livres », l’approche des idées en science-fiction et la perspective historique.
Le post-humanisme chinois et la science-fiction politique de Chen Qiufan
Authors: Judy Ron S. 
Published: June 2024

Chen Qiufan, l’un des plus jeunes auteurs de science-fiction en Chine aujourd’hui, est le plus souvent associé au cyberpunk, principalement parce qu’il est ancré dans une critique du futur proche et qu’il s’intéresse à la manière dont la biotechnologie affecte et modifie notre perception du corps humain. Cet article examine les dimensions « posthumanistes » de trois récits de science-fiction de Chen Qiufan (alias Stanley Chan) : « Smog Society » (2010), « Year of the Rat » (2009) et « The Flower of Shazui » (2012), dans le but d’établir s’il existe des différences substantielles entre le posthumanisme chinois et le posthumanisme euro-américain. Je conclus provisoirement qu’il existe des différences ; la principale étant que la variante chinoise est plus directement « post-humaniste » (c’est-à-dire affiliée à l’humanisme philosophique) dans la mesure où elle reste profondément concernée par l’idée marxiste-humaniste de l’agentivité aliénée.
RECENT ADVANCES IN THE DEFINITION OF THE MOLECULAR ALTERATIONS OCCURRING IN MULTIPLE MYELOMA
Authors: Testa Ugo , Pelosi Elvira , Castelli Germana , Leone Giuseppe 
Published: June 2024

Multiple myeloma (MM) is a disorder of the monoclonal plasma cells and is the second most common hematologic malignancy. MM initiation and progression are dependent upon complex genomic abnormalities. The current pathogenic model of MM includes two types of primary events, represented by chromosome translocations or chromosome number alterations resulting in hyperdiploidy. These primary molecular events are observed both in MM and in monoclonal gammopathy, its premalignant precursor. Subsequent genetic events allow the progression of monoclonal gammopathy to MM and, together with primary events, contribute to the genetic complexity and heterogeneity of MM.
Newer therapies have considerably improved patient outcomes; however, MM remains an incurable disease and most patients experience multiple relapses.
The dramatic progresses achieved in the analysis of the heterogeneous molecular features of different MM patients allowed a comprehensive molecular classification of MM and the definition of an individualized prognostic model to predict an individual MM patient’s response to different therapeutic options. Despite these progresses, prognostic models fail to identify a significant proportion of patients destined to early relapse. Treatment strategies are increasingly. Based on disease biology, trials are enriched for high-risk MMs, whose careful definition and categorization requires DNA sequencing studies.

Keywords: Multiple Myeloma; Chromosome Abnormalities; Molecular Events; Mutations.
Increasing Blood Oxygen Saturation following 6 minutes’ Walk Test in Healthy Human Volunteers with Coca erythroxylon 6CH and Vanadium metallicum 6CH: A Double-blind, Randomized, Placebo-controlled Pilot Trial
Authors: Mandal Dibyendu , Ansary Samiul , Gunin Amit , Saha Subhranil , Midya Ayan , Das Suhisna , Mukherjee Shyamal Kumar 
Published: June 2024

Abstract

Background:
Oxygen saturation (SpO2) is an essential component during patient care and management because a variety of acute negative consequences on specific organs and systems can result from hypoxemia.

Aim and Objective:
The effects of two homeopathic medicines, Coca erythroxylon 6CH and Vanadium metallicum 6CH, were explored against placebos on blood SpO2 following a 6-min walk test (6MWT) in apparently healthy human volunteers after 3 days of intervention.

Subjects and Methods:
A 3-day, randomized (1:1:1), double-blind, placebo-controlled pilot trial was conducted on 60 healthy human volunteers. Participants were randomized to Coca erythroxylon (n = 20), Vanadium metallicum (n = 20), and identical-looking placebos (n = 20). Blood SpO2% (primary), peak expiratory flow (PEF; mL), and breath holding timing (s) were measured at baseline once preintervention and postintervention and again before and after a 6MWT. Interventions were administered 4 times a day for 3 consecutive days. Group differences were estimated using a one-way analysis of variance. Significance levels were set at P < 0.05 two-tailed.

Results:
Statistically significant differences in pre- and postintervention mean changes were observed in blood SpO2% in the Coca erythroxylon group in comparison with the others (F
2,57 = 3.815, P = 0.028); however, no such significant differences could be observed in PEF and breath holding time. No adverse events were reported.

Conclusion:

Coca erythroxylon significantly increased blood SpO2% following a 6MWT in healthy human volunteers. It is necessary to conduct definitive trials to validate the findings.

Trial Registration: CTRI/2022/08/044810; UTN: U1111-1281-3263.
The Benefits of Physical Indoor Activity during Self-Quarantine
Authors: Bhutada Roshna Sukhdevji 
Published: June 2024

Abstract
The on-going novel coronavirus 2019 from the outbreak of China is affecting many more countries almost 213 have been reported. The highest number of cases till July 10, 2020, is from the country United States. India is the 2nd most country which has been affected by novel coronavirus 2019. In certain nations, wellness focuses and different areas where people are typically dynamic will remain briefly shut. Remaining at home for delayed timeframes can represent a critical test for residual truly dynamic. Self-quarantine can likewise cause extrapressure and challenge the emotional well-being of residents. Physical action and unwinding procedures can be significant apparatuses to assist you with staying cool and keep on securing your well-being during this time. Physical activity should not be confused with exercise. Physical activity means the movement of the body that uses the energy. It can be moderate or vigorous intensity. Let’s be active everyone and every day. Regular physical activity reduces the risk of noncommunicable diseases such as blood pressure, ischemic heart disease, stroke, blood sugar level, and colon and breast cancer. All conditions increase the susceptibility to COVID-19. Moreover, mainly in the lockdown, the new things for people it will help you from to maintain your weight and from anxiety and depression.
Evaluation of Efficacy of MV Loop for En masse Anterior Retraction as Compared to Opus and Snail Loop Using Finite Element Method and Clinical Intervention: A Research Protocol
Authors: Jadhav Vikrant V. , Kamble Ranjit , Shrivastav Sunita , Thote Abhishek , Tiwari Meenakshi 
Published: June 2024

Abstract

Background:
In orthodontics, space closure after extraction is crucial. Frictionless mechanics in preadjusted “edgewise appliance” treatment in orthodontics are better alternatives to friction mechanics. The major benefit is dissipation of force, a high M: F ratio and a low load-deflection rate which is not there in friction mechanics. The retraction loops are Snail loop, Opus loop, K Sir loop, L loop etc. which are used as force system in frictionless mechanics.

Objectives:
To evaluate and compare the efficacy of Multiple Variability (MV) loop for qualitative and quantitative en masse anterior retraction as compared to Opus and Snail loop.

Materials and Methods:
The study will be carried out in the Department of Orthodontics and Dentofacial Orthopaedics, Sharad Pawar Dental College, Sawangi (M), Wardha with the technical assistance from NIT Engineering College, Pune. MV loop, Opus loop and Snail loop will be fabricated in “0.019 × 0.025, 0.017 × 0.025 inch Titanium Molybdenum alloy (TMA) and 0.017 × 0.025 inch Stainless Steel (SS) wire” with 1 and 2 mm preactivation bends will be analysed on Finite element method (FEM) Software. Then clinical trials will be carried out based on qualitative and quantitative assessment of records for evaluation of MV loop, opus loop and Snail loop.

Expected Results:
The FEM analysis and clinical trials will predict the perfect design of loop with adequate preactivation bends. Mainly on data access layer (DHAL) analysis MV loop showed 10:1 Moment to Force (M:F). Similar results are expected on FEM analysis and clinical trials. MV loop will show superior results as compared to Opus and Snail loop.

Conclusion:
Loop mechanics provide efficient intrusion and retraction in extraction cases. A loop to be effective and efficient needs to clinically as well as mechanically evaluated. MV loop was fabricated to fulfill all the requirements of loop. Clinical evaluation of loop will provide complete effectiveness of loop.
Presence of Pathogenic Enterobacteriaceae on Fingertips of Food Handlers
Authors: Khurana Kartik M. , Hassani Umesh S. 
Published: June 2024

Abstract

Introduction:
Food handlers who prepare or handle food and utensils used to prepare or transport food can contaminate food directly or indirectly. Indirect transmission is generally caused by contamination of the fingers of the food handlers. Compared to other parts of the hand, the parts beneath the fingernails, which are the nail beds, can act as vectors that spread microorganisms through cross-contamination.

Objectives:
The objectives of this study are to determine the hygienic status and transport of pathogenic Enterobacteriaceae at the fingertips of food handlers, a study was carried out.

Methodology:
A community-wide cross-sectional study was conducted, considering 50 participants from the medical college; the swabs were taken from the nail beds and fingertips to the laboratory to inoculate over the selective medium, i.e., MacConkey agar and XLD agar. The data were analyzed using Epi Info statistical software.

Results:
Fifty participants were tested for the presence of pathogenic Enterobacteriaceae on both hands, of which only 11 (22%) participants tested negative for Enterobacteriaceae growth on either of their hands. Of 50, 30 participants had their nails properly trimmed and 31 participants said they would not work if they got sick.

Conclusions:
There is a need to educate food handlers about their hygiene and the effect of their hygiene on the possibility of contamination of food. Management must take active steps to minimize the possibility of food contamination.
Impact of Artificial Intelligence and Machine Learning on Urological Practice
Authors: Ali Muhammad Jabran Abad , Rangraze Imran 
Published: June 2024

Abstract
Artificial intelligence (AI) has revolutionized urology while reshaping clinical practice and research. It excels in predicting treatment outcomes and enhancing disease diagnosis accuracy, particularly in bladder disorders such as interstitial cystitis, bladder cancer, and reproductive urology. AI’s data analysis capabilities enable early detection and prognosis by identifying patterns in vast datasets. It paves the way for more personalized treatments and reshapes disease classification. In the age of “big data,” AI simplifies complex healthcare information while improving decision-making and patient care. In addition, physical AI applications in robot-assisted surgery and nanotechnology enhance drug administration precision, surgical effectiveness, and patient outcomes. This review highlights AI’s pivotal role in identifying and treating urological disorders, aiding surgical guidance, and advancing tissue engineering, showcasing its significant impact and ongoing progress in the field of urology.
Exploring the Severity of Kinesiophobia at Hospital Discharge in Patients Undergone Abdominal Surgery
Authors: Jaiswal Varoon C. , Misquitta Chenessa , Deshpande Priya , Pawar Pournima , Burman Deepika , Shetty Ramya Anand , Bhondve Arpita , Bhondve Arpita 
Published: June 2024

Abstract

Objective:
The objective of the study was to explore the severity of kinesiophobia at hospital discharge in individuals undergone abdominal surgery by using the Tampa Scale of Kinesiophobia-11 (TSK-11).

Materials and Methods:
A cross-sectional observational study was carried out in a tertiary care hospital. Purposive sampling was used to select the individuals. A total of 80 participants (n = 80) were included in the study. The subjects were given the Marathi version of TSK-11. All responses were collected and statistically analyzed.

Results:
There were 80 participants in this study, from which 70% displayed combined “Low” and “Moderate” kinesiophobia levels. This data were collected on the day of discharge, which varied because each of the patients had different lengths of stay. The severity of kinesiophobia in these individuals displayed low-to-moderate levels of kinesiophobia due to the tolerance of pain as it differs from individual to individual.

Conclusions:
The study reveals that low-to-moderate kinesiophobia is common after abdominal surgery. Treatment of kinesiophobia can increase patient well-being and recovery through individualized therapy, early intervention, and psychological support. This study adds insight into postabdominal surgery kinesiophobia, highlighting varying severity levels within this population. Detecting and treating kinesiophobia in abdominal surgery patients can result in customized rehab, fewer complications, and improved health outcomes, promoting overall recovery.
Effectiveness of Eye Exercises in Individuals with Presbyopia: A Randomized Controlled Trial
Authors: Heggannavar Anand , Tenagi Arvind L. , Pathak Geetan Manoj 
Published: June 2024

Abstract

Background:
Presbyopia is a disorder of the eyes that affects both visual quality and quality of life. It is caused by a steady decline in amplitude accommodation, which is expected to occur with age.

Aims and Objectives:
To investigate the impact of eye exercises on visual acuity, refractive errors, and the Near Activity Vision Questionnaire among individuals with presbyopia.

Methods:
This study comprised 34 presbyopic participants who met the inclusion criteria and were evaluated for visual acuity and refractive error by an ophthalmologist. The individuals were split up into two groups. Group A received treatment from an ophthalmologist alone, while Group B received treatment from an ophthalmologist in addition to eye exercises for 2 months.

Results:
The statistical analysis of this study suggested that Group B shows a statistically significant difference in visual acuity of the right (P = 0.01) and left eyes (0.020) and overall satisfaction with near vision (P = 0.001) but not in refractive error of the right and left eyes (P = 0.074 and P = 0.193).

Conclusion:
It has been discovered that eye exercises are clinically beneficial in reducing the symptoms of astenopic, enhancing near vision tasks, and increasing near vision satisfaction overall, but not in reducing refractive error.
Evaluation of Elective Posting on Adverse Drug Reaction and Pharmacovigilance under Competency-based Medical Education Curriculum among Undergraduates: A New Step in Medical Education
Authors: Narwane Sandeep Prakash , Agrawal Palak Ashokkumar , Mahavarakar Varsha Narsingrao 
Published: June 2024

Abstract

Context:
The revised competency-based medical education, the students of 3rd-year part I MBBS are required to undergo elective postings of 1 month based on the student’s needs and choice.

Aims:
This study was undertaken to evaluate the outcome of elective posting of pharmacovigilance and adverse drug reaction (ADR) reporting as a new teaching tool in pharmacology among 3rd-year part I MBBS students.

Settings and Design:
The students undergoing the elective posting of pharmacovigilance and ADR reporting were evaluated for their knowledge, completeness score (out of 10) of ADRs reported, and their feedback with respect to the posting, in a pretested questionnaire.

Subjects and Methods:
It was a descriptive cross-sectional type conducted in the Pharmacology Department of Dr. Balasaheb Vikhe Patil Rural Medical College and Dr. Vitthalrao Vikhe Patil Pravara Rural Hospital, Loni.

Results:
Six students participated in the study, who reported 96 ADRs. Most of the ADRs (39, 40.6%) were reported immediately after their appearance. The average completeness score of the ADRs reported was 9.44 ± 0.41. The students gave an average score of 1.2 for overall experience of the posting (1 – best and 5 – worst).

Conclusions:
The elective posting with pharmacovigilance and ADR reporting module had a positive impact on the quality of ADR reporting in terms of completeness, causality assessment as well as time of reporting. The students felt confident in reporting ADRs and reflected positively toward the training module.