bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal course and predictors of suicidal ideation in a rural community sample
Authors: Handley Tonelle E , Attia John R , Inder Kerry J , Kay-Lambkin Frances J , Barker Daniel , Lewin Terry J , Kelly Brian J 
Published: June 2013

Objective: Suicide rates in rural Australia are higher than in urban areas. No existing research has explored the long-term patterns and predictors of change in suicidal ideation within rural areas. This report uses longitudinal data and multiple time points to determine predictors of the trajectory of suicidal ideation in rural Australia. Method: Participants in the Australian Rural Mental Health Study (ARMHS) completed self-report surveys at baseline, 12 and 36 months, reporting their psychological and social well-being, and suicidal ideation. Generalised linear mixed models explored these factors as correlates and predictors of suicidal ideation across 3 years using multiple data points. Results: A total of 2135 participants completed at least one wave of ARMHS, and hence were included in the current analysis. Overall, 8.1% reported suicidal ideation during at least one study wave, 76% of whom reported suicidal ideation intermittently rather than consistently across waves. Across the three time points, suicidal ideation was significantly associated with higher psychological distress (OR 1.30, 95% CI 1.23 to 1.37), neuroticism (OR 1.15, 95% CI 1.04 to 1.27), and availability of support (OR 0.80, 95% CI 0.69 to 0.92), with a non-significant association with unemployment (OR 1.73, 95% CI 0.93 to 3.24) even after controlling for the effects of perceived financial hardship. Future suicidal ideation was significantly predicted by distress (OR 1.16, 95% CI 1.09 to 1.23) and neuroticism (OR 1.17, 95% CI 1.03 to 1.32), with a non-significant association with unemployment (OR 2.11, 95% CI 0.41 to 2.27). Predictive effects for marital status, social networks, sense of community and availability of support did not remain significant in the full multivariate analysis. Conclusions: Fluctuations in suicidal ideation are common, and may be associated with changes in psychological and social well-being. Public health strategies, focusing on encouraging help-seeking among those with higher psychological distress, lower social support, and unstable or absent employment opportunities, may be a useful long-term initiative to reduce the prevalence of suicidal ideation in the general rural community.
A systematic review and meta-analysis of the effect of an ankle-foot orthosis on gait biomechanics after stroke
Authors: Tyson SF , Sadeghi-Demneh E , Nester CJ 
Published: June 2013

Objective: To systematically review the evidence on the effects of an ankle-foot orthosis on gait biomechanics after stroke Data sources: The following databases were searched; AMED, CINHAL, Cochrane Library (Stroke section), Medline, PubMed, Science Direct and Scopus. Previous reviews, reference lists and citation tracking of the selected articles were screened and the authors of selected trials contacted for any further unpublished data. Review methods: Controlled trials of an ankle-foot orthosis on gait biomechanics in stroke survivors were identified. A modified PEDro score evaluated trial quality; those scoring 4/8 or more were selected. Information on the trial design, population, intervention, outcomes, and mean and standard deviation values for the treatment and control groups were extracted. Continuous outcomes were pooled according to their mean difference and 95% confidence intervals in a fixed-effect model. Results: Twenty trials involving 314 participants were selected. An ankle-foot orthosis had a positive effect on ankle kinematics ( P < 0.00001–0.0002); knee kinematics in stance phase ( P < 0.0001–0.01); kinetics ( P = 0.0001) and energy cost ( P = 0.004), but not on knee kinematics in swing phase ( P = 0.84), hip kinematics ( P < 0.18–0.89) or energy expenditure ( P = 0.43). There were insufficient data for pooled analysis of individual joint moments, muscle activity or spasticity. All trials, except one, evaluated immediate effects only. Conclusions: An ankle-foot orthosis can improve the ankle and knee kinematics, kinetics and energy cost of walking in stroke survivors.
Lack of hemodynamic interaction between CGRP-receptor antagonist telcagepant (MK-0974) and sumatriptan: Results from a randomized study in patients with migraine
Authors: Depré M , MacLeod C , Palcza J , Behm MO , de Lepeleire I , Han T , Panebianco D , Smith WB , Blanchard R , Chodakewitz JA , Murphy MG , de Hoon JN 
Published: June 2013

Objective The objective of this article is to assess the effects of sumatriptan monotherapy, telcagepant monotherapy, and their combination on blood pressure (BP) in migraine patients during a headache-free period. Methods A double-blind, placebo-controlled, four-period, single-dose, randomized crossover study in 24 migraine patients was conducted. In each period, patients received a single oral dose of sumatriptan 100 mg alone, telcagepant 600 mg alone, sumatriptan 100 mg coadministered with telcagepant 600 mg, or placebo. Semi-recumbent BP was measured pre-dose and at seven post-dose timepoints over a period of six hours. Individual time-weighted averages in mean arterial pressure (MAP) were evaluated using a linear mixed-effects model. The pharmacokinetics of sumatriptan alone and in the presence of telcagepant were also evaluated using limited sampling times. Results The mean difference in time-weighted (0–2.5 h) MAP (90% confidence interval) was 1.2 mmHg (−0.2, 2.7) between telcagepant and placebo, 4.0 mmHg (2.5, 5.5) between sumatriptan and placebo, and 1.5 mmHg (0.0, 3.0) between telcagepant with sumatriptan vs sumatriptan alone. When coadministered with telcagepant, the AUC0–6h and Cmax of sumatriptan were increased by 23% and 24%, respectively. The small MAP increases observed after coadministration could possibly be associated with the slight elevations in sumatriptan levels. Conclusion Telcagepant does not elevate mean MAP, and coadministration of telcagepant with sumatriptan results in elevations in MAP similar to those observed following administration of sumatriptan alone in migraineurs during the interictal period. When coadministered, telcagepant slightly increases the plasma levels of sumatriptan, but without an apparent clinically meaningful effect.
Approach to produce rigid closed-cell polyimide foams
Authors: Wang Leilei , Hu Aijun , Fan Lin , Yang Shiyong 
Published: June 2013

A new chemical approach to prepare rigid closed-cell polyimide foams (PIFs) has been developed by thermal foaming of nadimide end-capped imide oligomers (NAIOs) obtained by thermally treating an in situ polymerization of monomeric reactant (PMR)-type poly(amide ester) resin solution. The PMR poly(amide ester) was synthesized by the reaction of diethyl ester of 2,3,3′,4′-biphenyltetracarboxylic dianhydride and aromatic diamines using monoethyl ester of cis-5-norbornene-endo-2,3-dicarboxylic acid as reactive end-capping agent in ethyl alcohol. The thermal foaming properties of the NAIOs were investigated. It was found that thermal foaming of the NAIOs was attributed to the blowing of cyclopentadiene, which was evolved from thermal decomposition of the nadimide end-caps in the imide oligomer by the reverse Diels–Alder reaction during cross-linking of the bisnadimide oligomers. The resultant rigid PIFs showed uniform cellular structures with high closed-cell content ( Cc) as well as high thermal stability and mechanical properties. The PIF with a density of 100 kg m−3 and a Cc of 89% exhibited compression strength at 10% compressive deformation of 1.34 MPa and outstanding thermal stabilities, making it a desirable candidate as high temperature structural foam materials for applications in aviation and spacecraft industries.
Herpes simplex virus type 2 incidence and associated risk factors among female sex workers in a high HIV-prevalence area of China
Authors: Wang H , Reilly K H , Smith M K , Brown K , Jin X , Xu J , Ding G , Zang C , Wang J , Wang N 
Published: June 2013

Summary Herpes simplex virus type 2 (HSV-2) can contribute to the spread of HIV. From March 2006 to November 2009, female sex workers (FSWs) in Yunnan, China were recruited into an open cohort study to determine incidence and risk factors for HSV-2 acquisition. Participants were interviewed and tested for HSV-2 and other sexually transmitted infections (STIs) every six months. A multivariate Cox proportional hazards regression model with time-dependent variables was used to measure associations with HSV-2 acquisition. In 3.5 years, 83 incident cases of HSV-2 infection were diagnosed, yielding an overall incidence of 21.9 per 100 person years (PY) (95% confidence interval [CI], 17.8–26.3). Working in higher risk commercial sex venues, current Neisseria gonorrhoeae infection, age of sexual debut <18 years and lack of a regular sex partner were independent factors associated with HSV-2 acquisition. The high incidence of HSV-2 suggests that prevention methods for HIV/STI control are urgently needed.
Women's preferences for testing and management of sexually transmitted infections among low-income New York City family planning clients
Authors: Jones H E , Holloway I W , Pressman E , Meier J , Westhoff C L 
Published: June 2013

Summary High prevalence of chlamydia in the USA persists despite efforts to annually screen women under the age of 26. Tailoring sexually transmitted infection (STI) services to client preferences may strengthen existing programmes. We report women's preferences for STI services from a family planning clinic in New York City serving low-income women. Seventy-eight percent (995/1275) of eligible women participated, with a mean age of 26 (SD±7). Ninety-one percent self-identified as Latina. Nineteen percent reported a past STI. Women preferred self-collection (65%) for testing to a speculum exam (20%); 15% had no preference. Women with a previous STI were more likely to prefer a pelvic exam to women with no previous STI (50% versus 32%, P < 0.01). Nearly all women (94%) preferred informing a sex partner about a positive STI test themselves, but 88% were willing to bring expedited partner therapy to a partner. Women were more likely to prefer third party partner notification if their last partner was casual rather than a main partner (14% versus 3%, respectively, P < 0.01). Forty-four percent of participants worried about physical violence after partner notification. Self-collecting specimens for screening was widely acceptable. Partner notification strategies should be based on understanding partnership status, including fears of violence.
Cylinder-to-cylinder variation sources in diesel low temperature combustion and the influence they have on emissions
Authors: Bittle Joshua , Zheng Junnian , Xue Xingyu , Song Hoseok , Jacobs Timothy 
Published: June 2013

Cylinder-to-cylinder variation in a multi-cylinder diesel engine was found to increase substantially when transitioning to a low-temperature combustion mode. This study was started to investigate the potential influence this effect could have on the emissions levels. Initial testing showed an imbalance in the fuel distribution that prompted this article to focus on data from before and after swapping two injectors under both conventional and low-temperature combustion modes. A significant improvement is observed in cylinder variation based both on visual heat release inspection and on mean effective pressure variation. This is likely a result of a changing combination of exhaust gas recirculation and fuel distribution such that less cylinder-to-cylinder variation is present (e.g. high dilution and low fuel, switched to low dilution and low fuel). Interestingly, despite the reduced cylinder-to-cylinder variation, the results show that the emissions levels are actually not affected. Despite the lack of influence on emissions results, the cylinder-to-cylinder variation in low-temperature combustion modes is still a critical factor that could impact its ability to be implemented in a commercial setting. Further cylinder balancing was attempted and achieved by introducing small (microsecond) adjustments to each cylinder start of injection and injection duration. The balancing is effective, but due to exhaust gas recirculation imbalance, a single adjustment setting does not apply to both conventional and low-temperature combustion modes. Additionally, day-to-day ambient conditions also negate the effectiveness. This supports the idea that some type of consumer-based real-time automatic balancing system may be needed in the future.
Causes of recurrent lower limb varicose veins after surgical interventions in 141 limbs – Five-year retrospective analysis of two centers
Authors: Hua Wang Rui , Yi Meng Qing , Jun Wu Xue , Xing Jin , Xuan Liu Zhao , Bo Li 
Published: June 2013

Aim The purpose of this study was to explore the causes of recurrent lower limb varicose veins after surgical interventions. Methods A retrospective five-year survey was conducted on patients who underwent second surgery due to recurrent lower limb varicose veins after surgical interventions. A total of 141 limbs (112 cases), including 72 cases of left lower limbs, 47 of right lower limbs and 22 of both limbs, were involved in the study. All patients underwent lower limb venography (141 limbs were anterograde and 28 cases were retrograde), and then examined with color-Doppler ultrasound. Results The major causes that urged patients to undergo second surgery are clinical changes graded above CEAP IV (93.6%), limb edema without changes on skin (5%), and single varicosity (1.4%). Up to 127 (83%) limbs exhibited perforating venous reflux, 67 (47.5%) limbs had varied degrees of deep venous insufficiency and 68 (48.2%) limbs had through or above-the-knee great saphenous vein trunk residual. Conclusions Preoperative venography before operation is indispensible in confirming the diagnosis and operation strategies. Patients with severe primary deep venous reflux and symptoms up to C3 may need simultaneous repair of the deep venous valves.
Factors affecting satisfaction with treatment in European women with chronic constipation: An internet survey
Authors: Emmanuel Anton , Quigley Eamonn MM , Simrén Magnus , Feng Yue , Müller‐Lissner Stefan , Urbain Daniel , Tack Jan , Bredenoord Albert J , Sabaté Jean‐Marc , Yiannakou Yan , Andresen Viola , Cuomo Rosario , Rey Enrique , Gryp Renate Specht , Vandeplassche Lieve , Solomon Dory 
Published: June 2013

BackgroundData on factors affecting treatment satisfaction in European women with chronic constipation are limited.ObjectiveTo assess factors associated with treatment satisfaction among European women with chronic constipation.MethodsA 2011–2012 internet survey was conducted in men and women from 12 European countries. Respondents analysed were female with self‐reported chronic constipation (≥1 symptoms for ≥6 months of lumpy/hard stools, feeling of incomplete evacuation, and pain during defecation, as well as <3 bowel movements/week). For laxative users, satisfaction with treatment, factors affecting satisfaction, and interactions with healthcare professionals were collected.Results and conclusionsIn total, 4805/50,319 participants fulfilled the inclusion criteria (female with chronic constipation). Of the laxative users (1575/4805), 57% (n  = 896) were satisfied with their treatment, while 26% were neutral, and 17% dissatisfied. Dissatisfied respondents visited their GP less frequently in the past 12 months, were more likely to obtain over‐the‐counter laxatives, and took a dose higher than recommended more frequently than those satisfied. Respondents were most satisfied with ease of use of treatment and least satisfied with relief from bloating. Newer treatments aimed at alleviating symptoms, particularly bloating, are required for respondents neutral or dissatisfied with their current treatment.
Application of international consensus diagnostic criteria to an Italian series of autoimmune pancreatitis
Authors: Ikeura Tsukasa , Manfredi Riccardo , Zamboni Giuseppe , Negrelli Riccardo , Capelli Paola , Amodio Antonio , Caliò Anna , Colletta Giulia , Gabbrielli Armando , Benini Luigi , Okazaki Kazuichi , Vantini Italo , Frulloni Luca 
Published: June 2013

BackgroundInternational consensus diagnostic criteria (ICDC) have been proposed to classify autoimmune pancreatitis (AIP) in type 1, type 2, or not otherwise specified.ObjectiveAim was to apply the ICDC to an Italian series of patients to evaluate the incidence and clinical profiles among different subtypes of AIP.Methodswe re‐evaluated and classified 92 patients diagnosed by Verona criteria, according to the ICDC.ResultsOut of 92 patients, 59 (64%) were diagnosed as type 1, 17 (18%) as type 2, and 15 (16%) as not otherwise specified according to the ICDC. A significant difference between type 1 and type 2 were found for age (54.5 ± 14.5 vs. 34.4 ± 13.9 respectively; p  < 0.0001), male sex (76 vs. 47%; p  = 0.007), jaundice (66 vs. 18%; p  = 0.002) and acute pancreatitis (9 vs. 47%; p  < 0.0001), elevated serum IgG4 levels (85 vs. 7%; p  < 0.0001), inflammatory bowel disease (8 vs. 82%; < 0.0001), and relapse of the disease (34 vs. 6%; p  = 0.058). Imaging and response to steroids in the not‐otherwise‐specified group were similar to type 1 and 2.ConclusionsType 1 has a different clinical profile from type 2 autoimmune pancreatitis. The not‐otherwise‐specified group has peculiar clinical features which are shared both with type 1 or type 2 groups.
Tumor-derived tissue factor–positive microparticles and venous thrombosis in cancer patients
Authors: Geddings Julia E. , Mackman Nigel 
Published: June 2013

Abstract
Patients with cancer have an increased risk for venous thrombosis. Interestingly, different cancer types have different rates of thrombosis, with pancreatic cancer having one of the highest rates. However, the mechanisms responsible for the increase in venous thrombosis in patients with cancer are not understood. Tissue factor (TF) is a transmembrane receptor and primary initiator of blood coagulation. Tumor cells express TF and spontaneously release TF-positive microparticles (MPs) into the blood. MPs are small membrane vesicles that are highly procoagulant. It has been proposed that these circulating tumor-derived, TF-positive MPs may explain the increased rates of venous thrombosis seen in patients with cancer. In animal models, increased levels of tumor-derived, TF-positive MPs are associated with activation of coagulation. Moreover, these MPs bind to sites of vascular injury and enhance thrombosis. We and others have found that patients with cancer have elevated levels of circulating TF-positive MPs. These MPs are derived from tumors because they express tumor markers and are decreased by tumor resection. Importantly, several studies have shown that increased levels of TF-positive MPs correlate with venous thrombosis in patients with cancer. Taken together, these results suggest that TF-positive MPs may be a useful biomarker to identify patients with cancer who are at high risk for thrombosis.
An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection
Authors: Tsai Tsung-Ting , Chuang Yi-Jui , Lin Yee-Shin , Wan Shu-Wen , Chen Chia-Ling , Lin Chiou-Feng 
Published: June 2013

AbstractInfection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, involving viral cytotoxicity, immunopathogenesis, autoimmunity, and underlying host diseases. Viral load correlates with disease severity, while the antibody-dependent enhancement of infection largely determines the secondary effects of DENV infection. Epidemiological and experimental studies have revealed an association between the plasma levels of interleukin (IL)-10, which is the master anti-inflammatory cytokine, and disease severity in patients with DENV infection. Based on current knowledge of IL-10-mediated immune regulation during infection, researchers speculate an emerging role for IL-10 in clinical disease prognosis and dengue pathogenesis. However, the regulation of dengue pathogenesis has not been fully elucidated. This review article discusses the regulation and implications of IL-10 in DENV infection. For future strategies against DENV infection, manipulating IL-10 may be an effective antiviral treatment in addition to the development of a safe dengue vaccine.
Involvement of STIM1 and Orai1 in EGF-mediated cell growth in retinal pigment epithelial cells
Authors: Yang I-Hui , Tsai Yao-Ting , Chiu Siou-Jin , Liu Li-Teh , Lee Hsuan-Hung , Hou Ming-Feng , Hsu Wen-Li , Chen Ben-Kuen , Chang Wei-Chiao 
Published: June 2013

Abstract

Background
In non-excitable cells, one major route for calcium entry is through store-operated calcium (SOC) channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca2+ store. STIM1 and Orai1 are major regulators of SOC channels. In this study, we explored the functions of STIM1 and Orai1 in epidermal growth factor (EGF)-induced cell proliferation and migration in retinal pigment epithelial cells (ARPE-19 cell line).

Results
EGF triggers cell proliferation and migration in ARPE-19 cells. Cell proliferation and migration involve STIM1 and Orai1, as well as phosphorylation of extracellular signal-regulated protein kinase (ERK) 1/2, and Akt. Pharmacological inhibitors of SOC channels and siRNA of Orai1 and STIM1 suppress cell proliferation and migration. Pre-treatment of mitogen-activated protein kinase kinase (MEK) inhibitors and a phosphatidylinositol 3 kinases (PI3K) inhibitor attenuated cell proliferation and migration. However, inhibition of the SOC channels failed to prevent EGF-mediated ERK 1/2 and Akt phosphorylation.

Conclusions
Our results showed that STIM1, Orai1, ERK 1/2, and Akt are key determinants of EGF-mediated cell growth in ARPE-19 cells. EGF is a potent growth molecule that has been linked to the development of PVR, and therefore, STIM1, Orai1, as well as the MEK/ERK 1/2 and PI3K/Akt pathways, might be potential therapeutic targets for drugs aimed at treating such disorders.