bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Climate Change on Mental Health: A General Population Study
Authors: Uçak R. , Ayhan C. H. , Aktaş M. C. , Kaynar Demirel N. 
Published: August 2024

Introduction
Climate change and its impact on mental health is a growing area of research. Several studies have explored the relationship between climate change and mental health, highlighting the various ways in which climate change can affect individuals’ psychological well-being. Incorporating mental health indicators into climate change and health vulnerability and adaptation assessments is another important aspect of research in this area (Hayes & Poland, 2018). The study suggests that standardized methods to measure and predict the psychosocial outcomes of climate change should be implemented to better understand the mental health impacts. While the physical health consequences of climate change have received more attention, the mental health impacts are often overlooked (Nicholas et al., 2020).ObjectivesThis study was planned to examine the impact of climate change the impact of climate change on mental healthMethodsThis descriptive and cross-sectional study was conducted with individuals who willing to participate the study and above 18 years age. Individuals who saw the online advertisement and click on the study’s link were be brought to the study’s home page on Online Surveys. Should they wish to proceed, they will be brought to an information page detailing the purpose of the study, how their confidentiality and anonymity will be preserved and how their data will be treated.Socio-Demographic Data Form, Climate Change Worry Scale, Eysenck Personality Questionnaire Revised- Abbreviated, general health questioner and Depression, Anxiety, Stress scale were used for collecting data. Data analyses was planned to run via Statistical Package for the Social Sciences version, 27.0.ResultsThe analysis of the data is still ongoing in detail by the researchers. The findings and relational implications of the study will be presented.Conclusions
In conclusion, this study highlight the importance of understanding the mental health impacts of climate change and developing strategies to address them. Climate change can have direct and indirect consequences on mental health, and vulnerable populations such as children and adolescents may be particularly at risk. Reducing psychological distance and incorporating mental health indicators into assessments can help in understanding and addressing the mental health consequences of climate change.Disclosure of InterestNone Declared
The activity of platelet enzymes and subpopulation composition of monocytes in schizophrenia
Authors: Prokhorova T. , Boksha I. , Sarmanova Z. , Savushkina O. , Tereshkina E. 
Published: August 2024

IntroductionThe studies on various groups of patients with schizophrenia revealed impairments in immune system, glutamatergic, and antioxidant systems contributing substantially in schizophrenia pathogenesis.Objectives
To search for links between the activities of platelet enzymes involved in glutamate and glutathione metabolism and monocytes’ subpopulation compositions in patients with schizophrenia and to identify possible correlations of the biomarkers with clinical data. Research objectives: determination of subpopulation ratio of monocytes; measurement of the activity levels of glutamate dehydrogenase (GDH), phosphate-activated glutaminase (PAG), glutathione reductase (GR) and glutathione S-transferase (GST) in blood platelets; search for correlations between these parameters and the scores by psychometric scales.Methods
The study included 36 women aged 16-45 years with acute schizophrenia hospitalized in the Mental Health Research Centre with their current condition assessed as depressive-delusional. The control group consisted of 17 women 18-45 years old without somatic or mental pathology. GDH, PAG, GR and GST activities were measured by spectrophotometric methods, and numbers of monocyte subpopulations - “classical”, “intermediate”, “non-classical” - by flow cytometry. The Hamilton Depression Rating Scale (HAMD-17) was used to assess depression severity. The data was processed using the Statistica 8.0 software.Results
The detected changes in monocyte subpopulations’ composition towards the increase in the proportion of cells having a pro-inflammatory phenotype (CD14++CD16+ “intermediate”) indicated the activation of inflammatory reactions. Also, the activities of platelet enzymes of glutathione metabolism (GR and GST) were significantly decreased (p<0.05). Moreover, GDH and GST activities significantly correlated with the scores by HAMD-17 (r=0.40, p=0.022 and r=0.45, p=0.030, respectively). The results indicate the presence of pathological inflammatory process, the decrease in activities of glutathione antioxidant metabolism enzymes and a link to glutamate metabolism involvement (GDH) in the studied patient group.Conclusions
The identified redistribution in the monocyte subpopulations’ composition and decrease in the activity of enzymes involved in glutamate metabolism and antioxidant system indicate the involvement of the immune, glutamate and antioxidant systems in the pathogenesis of schizophrenia and may reflect a functional interaction between these systems.Disclosure of InterestNone Declared
Assessment of Cognitive Performance and Psychophysiological Signals in Mental Patients by a Novel Method
Authors: Fűzi M. , Petró B. , Barna P. , Kósa K. 
Published: August 2024

IntroductionMental disorders often manifest broad cognitive deficits that detrimentally affect daily functioning. Stress indicated by heart rate variability (HRV) has been linked to these cognitive functions.ObjectivesWe aimed to develop a new method to assess cognitive performance and simultaneous measurement of psychophysiological signals related to stress and relaxation levels.Methods20 adult patients with mental disorders in a rehabilitation program were recruited along with 21 healthy volunteers. A test protocol was carried out with a purpose-developed computerized psychophysiological device. The protocol consisted of a relaxation period; digitized questionnaires on pathological distress (GHQ) and sense of coherence (SOC); gamified cognitive tasks to assess working memory, attention, and decision-making; and a final relaxation period. Acute stress was assessed by heart rate variability measured by a wireless ECG sensor. The inter-beat interval’s root mean square of successive differences (RMSSD) was calculated as an inverse stress measure. Relaxation levels were assessed by the relative power of the alpha frequency band measured by a commercial 4-channel EEG headband. Stress and relaxation levels were compared to the first relaxation period as a baseline.ResultsPatients scored worse than the reference group both regarding distress (d=7, p=0.004) and sense of coherence (d=-8, p=0.047). The cognitive performance of patients was significantly lower (p<0.001) than the reference group for all tasks.RMSSD at baseline tended to be lower for patients (d=-12.69, p=0.098), reflecting a higher level of physiological stress; 61% of patients started at an elevated stress level compared to 25% of the reference group. In addition, relative alpha levels at baseline were also lower (d=-5.8%, p=0.007) for patients.Compared to baseline, RMSSD decreased on average to 94% during cognitive assessments in patients and decreased to 91% by the end of the final relaxation. RMSSD decreased to 76% in the reference group and reached a final value of 78% of the baseline. Alpha levels slightly increased among patients during the tasks (103.4%) and then returned close to baseline (99.1%). For the reference group, alpha decreased during the tasks (95.5%) and then slightly increased (97.3%).ConclusionsPatients displayed heightened distress, reduced sense of coherence, and inferior cognitive scores compared to controls. While starting with higher stress, patients exhibited less elevation in stress during tasks, coupled with alterations in alpha levels, suggesting diminished engagement or focus. Our innovative method could aid in the diagnostics of cognitive performance in mental patients after further measurements for validation.Disclosure of InterestNone Declared
Intranasal esketamine efficacy as a treatment for treatment-resistant depression, case series
Authors: Delgado Marmisa C. , Álvarez Correa I. , Vizcaíno Herrezuelo H. , Egüen Recuero L. , Garrido Dobrito E. , Gayubo Moreo L. , Sanz-Aranguez B. , Delgado Tellez L. , Caballero Martínez L. , De Arce Cordón R. , Jiménez-Fernández B. 
Published: August 2024

IntroductionIntranasal esketamine has been approved as a treatment for patients with treatment-resistant depression. We analyzed the results of its efficacy in 15 patients.ObjectivesTo evaluate the efficacy of intranasal Esketamine as a treatment in patients with treatment-resistant depressionMethodsCase seriesResultsFor the last 8 months, since the treatment with intranasal esketamine was approved for resistant depression, we have treated 14 patients with this drug. Through this process, we followed a standardized method consisting in the following steps:On the first esketamine session (DAY 1) the patient has to fill a CGI and a MADRS scale.On the second esketamine session (DAY 7) the patient has to fill a CGI, a MADRS scale, a form about the level of satisfaction with the drug and a last form in which they can include the secondary effects.On week 6 since the start of the treatment, the patient has to fill again a CGI, a MADRS scale, a form about the level of satisfaction with the drug and a last form in which they can include the secondary effects.In the 6th month since the start of the treatment, the patient has to fill again a CGI, a MADRS scale, a form about the level of satisfaction with the drug and a last form in which they can include the secondary effects they have perceived.We analyzed and compared all of the previous data and obtained the following results:At day 7: 64% of the patients had a response in the form of improvement, of which 66% were feeling “slightly better” and 33% were feeling “better”.At week 6: 71% of the patients had a response in the form of improvement, of which 50% were feeling “slightly better” and the other 50% were feeling “better”.At month 6: only 28% of the patients completed the treatment; of which 100% had a response in the form of improvement: 50% were feeling “slightly better”, 25% were feeling “better” and 25% were feeling “far better”.ConclusionsAlthough our data suggests that intranasal esketamine has been effective in short term depressive symptoms, we have yet no information about its medium and long-term efficacy or secondary effects. Nevertheless, other potential factors should be evaluated as they could affect the results in the long-term such as the difficulty in maintaining the treatment for more than 6 weeks.In addition, the patients who experienced the most improvement according to our data were patients with a TAB diagnosis, so this could be an interesting research focus.Disclosure of InterestNone Declared
Non-Invasive Brain Stimulation for Perinatal Depressive Disorder: A Literature Review
Authors: Pinheiro Ramos C. , Alves M. , Durães D. , Mendes S. , Gamito A. 
Published: August 2024

IntroductionPeripartum Depressive Disorder (PPD) is a Peripartum Mental Disorder (PMD) characterized as a Major Depressive Disorder (MDD), wherein the manifestation of depressive symptoms initiates either during pregnancy or within the first 12 months following childbirth.PPD impacts both maternal well-being and infant health, resulting in unfavorable outcomes during pregnancy and the postpartum period.Non-Invasive Brain Stimulation (NIBS) is one of the rapidly expanding fields in medicine, using a range of techniques to modulate the brain.ObjectivesThis study aimed to summarize the latest evidence about the impact of NIBS (efficacy, tolerance, and safety) in PPD.MethodsA review was conducted, drawing on reputable (PubMed and Web of Science databases).Key brain stimulation modalities, such as Transcranial Magnetic Stimulation (TMS), Transcranial Electrical Stimulation (TES), and Electroconvulsive therapy (ECT) were analyzed in the context of PPD.ResultsPreliminary findings indicate promising positive effect of NIBS in reducing symptoms associated with PPD.In the postpartum, the favorable outlook on the effectiveness of NIBS implies that, when feasible, women diagnosed with mild to moderate PPD, especially those reluctant to initiate pharmacological interventions, should be presented with TMS or TES as an alternative therapeutic approach.However, some doubts persist about the safety of NIBS regarding fetus and preterm birth.ConclusionsNIBS constitutes a viable option for pharmacological and psychotherapeutic interventions, and it can also be integrated into comprehensive treatment regimens.Future research include large-scale clinical trials and longitudinal studies is needed to address the efficacy, security, and long-term effects of NIBS.Disclosure of InterestNone Declared
The perception of Romanian mental health professionals on electroconvulsive therapy
Authors: Anghel C. E. , Băcilă C. 
Published: August 2024

IntroductionThe journey for the electroconvulsive therapy began in 1938, when convulsive seizures induced by electrical stimulus were used, for the first time, in the therapy of patients diagnosed with Schizophrenia. Over the time, this therapy remains an important one, due to its applicability and necessity in the therapeutic management of patients with psychiatric pathology.ObjectivesElectroconvulsive therapy has evolved as a technique, nowadays being applied under induced intravenous anesthesia with the administration of oxygen on the mask, and from 2001, the sinus electrical stimulus has been replaced by the one in the form of a short pulse, upon the recommendation of professional organizations, in order to increase its therapeutic effectiveness. However, this form of therapy continues to be stigmatized, largely due to the way it is presented in the mass media. The objective of this work was to analyze how mental health professionals perceive electroconvulsive therapy.MethodsWe conducted a study in which we used a questionnaire applied to the Romanian professionals in the field of mental health.ResultsThe results were analyzed in accordance with the objective of the study.ConclusionsThrough this analysis we wanted to understand how electroconvulsive therapy is seen through the eyes of mental health professionals and to identify those aspects that can help us in carrying out information programs, with a major impact on mental health, in order to reduce stigma forasmuch the therapeutic benefits of electroconvulsive therapy outweigh the possible risks.Disclosure of InterestNone Declared
Compassion and the quality of life of the inpatient healthcare team
Authors: Bredicean A.-C. , Giurgi-Oncu C. , Palaghian L. , Tabugan D. , Neagu A. , Covaci G. , Homeag R. , Ursoniu S. 
Published: August 2024

Introduction
Nurse-patient relationships and interactions during inpatient care evoke feelings of empathy and compassion. Compassion can lead to satisfaction, but also to exhaustion. Compassion fatigue is a commonly used concept that signifies the exhaustion of healthcare personnel due to the specific activities and repeated exposure to the suffering of others. This manifests through physical and emotional over-tiredness, anxiety, anger and irritability, low vitality, social isolation, diminished sense of enjoyment of one’s career, cognitive disorders, and sleep disturbances.ObjectivesTo assess the level of compassion of the healthcare staff employed in a Romanian general hospital.Methods
The study sample included 256 nurses working in a general hospital. To identify socio-demographic data we applied a specific questionnaire, and subsequently we also used the PROQOL scale (Professional Quality of Life Scale). All data were statistically analysed.ResultsThe majority of healthcare professionals in our sample belong to the 40-49 age group (39.45%). Regarding work experience in the healthcare system, the majority(43%) have been working for over 10 years. 78.52% of nurses reported a high level of compassion satisfaction. Burnout was not identified in the majority of our sample (54.3%). We noted that the number of the staff affected by compassion fatigue increases proportionally with the years of work experience (P=0.033).ConclusionsA high level of compassion satisfaction in medical professionals leads to a remarkable improvement in the quality of the healthcare they are providing. However, our study results suggest that compassion fatigue tends to increase in line with the years of work in healthcareDisclosure of InterestNone Declared
Significant beneficial effects of 12-weeks add-on yoga therapy on antipsychotic-stabilized schizophrenia patients through epigenetic modulation: novel findings from a randomized controlled study
Authors: Debnath M. , Mullapudi T. , Govindaraj R. , Raj P. , Varambally S. 
Published: August 2024

IntroductionComplementary and alternative therapy, especially yoga, is emerging as an important treatment modality for various complex disorders. Yoga therapy has reportedly been demonstrated to exhibit clinical benefits in schizophrenia. However, the modulatory effects of yoga therapy on the pathobiological pathways of schizophrenia are inadequately explored. Immune dysregulation is a widely recognized etiopathological construct of schizophrenia. It is not precisely known whether yoga therapy can modulate the expression of immune molecules by regulating gene expression and epigenetic processes in schizophrenia.ObjectivesTo understand the impact of 12-weeks add-on yoga therapy on the immune-inflammatory pathway in schizophrenia by examining plasma levels and gene expression levels of cytokines and complement proteins as well as by profiling promoter DNA methylation pattern of genes coding for cytokines and complement proteins.MethodsFifty-seven schizophrenia patients fulfilling DSM-V criteria were recruited into the study and randomized into Yoga therapy (n=28) and waitlist control (n=29) groups. Plasma levels of IL-1β, IL-6, IL-10, IL-17, C1q, C2, C3, C4, C5, C5a, Factor B and Factor H by Multiplex Suspension Assay, quantification of gene expression of Il1b, Il6, Il10, IL17, C3, C4 and C5 genes by quantitative PCR and promoter DNA methylation of Il1b, Il6, Il10, Il17, C3, C4 and C5 genes by pyrosequencing were carried out in all the study participants.ResultsPlasma levels of IL-1β (Z score= 2.42, p=0.02) dropped significantly and C2 (Z score= 2.24, p=0.03) levels increased after 12-weeks of yoga therapy. The expression of Il1b (Z score=2.45, p=0.01) and Il6 (Z score=2.07, p=0.04) genes were significantly downregulated, while the levels of C4 (Z score=2.23, p=0.03) gene was upregulated in schizophrenia patients of yoga therapy group. Two CpG sites in the promoter region of Il1b (all p≤0.05) and Il6 (all p≤0.05) genes and three CpG sites in the promoter region of C4 (all p<0.05) gene were hypermethylated, while two CpG sites in the gene body of Il6 (all p≤0.05) gene and two CpG sites in the promoter region of Il10 (all p ≤0.05) gene were hypomethylated after 12-weeks of yoga therapy in schizophrenia patients.ConclusionsOur findings provide important insights into the mode of action of yoga therapy in schizophrenia. This study for the first time reports the epigenetic effects of yoga therapy on immune-inflammatory pathway in schizophrenia.Disclosure of InterestNone Declared
Connection between self-esteem and discontinuation of medication
Authors: Laabidi S. , Abidi O. , Aissa A. , Hosni R. , Ouali U. , Jomli R. 
Published: August 2024

IntroductionSelf-esteem entails evaluating oneself positively and often involves the need to be special and above average without comparisons with others. It could play a role in many areas of the patient’s life.ObjectivesThe aim of the present study was to find the prevalence of self-esteem and investigate the associations between self-esteem and treatment adherence in patients with schizophrenia spectrum disorders.Methods
This study involved outpatients with schizophrenia spectrum disorders ,according to (DSM-V) diagnostic criteria, attending the Department of Psychiatry A, Razi hospital between august and September 30, 2023. The level of self-esteem was measured with Rosenberg’s Self-Esteem Rating scale (SERS) and treatment adherence with the Medical Adherence Rating Scale (MARS).Socio-demographic characteristics were also collected.Results
Thirty stabilized outpatients with schizophrenia (n=18), schizoaffective disorder (n=11), brief psychotic disorder (n=1) were included in the study. The mean (SD) age of the respondents was 43.2years; the mean number of Hospital admissions was 4.7.Almost two thirds of this population (63.33% ) had low self-esteem and 36.67 % had high self-esteem. The level of self-esteem did not differ between diagnostic categories. Self-esteem also positively correlated with higher education and negatively with an increased number of hospitalizations. However, no significant association was found between socio-demographic variables and self-esteem. Adherence was further negatively correlated with age and age of onset of disorders. Patients suffering from schizophrenia had the lowest adherence to treatment.The results of the present preliminary study suggest a positive correlation between the SERS total scores and the MARS scores. It was found that higher levels of self- esteem are related with higher levels of treatment adherence and lower levels of self- esteem are associated with discontinuation of medications without a psychiatrist’s recommendation. This connection was present in all diagnostic groups.ConclusionsThis study shows positive relationship between self-esteem and treatment adherence. Further studies are needed to investigate whether self-esteem is a factor positively influencing adherence to treatment and show if self-esteem training programs like standard psychoeducation and cognitive behavioral therapy could be beneficial to improve treatment adherence among psychiatric patients.Disclosure of InterestNone Declared