bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bispecific small molecule–antibody conjugate targeting prostate cancer
Authors: Kim Chan Hyuk , Axup Jun Y. , Lawson Brian R. , Yun Hwayoung , Tardif Virginie , Choi Sei Hyun , Zhou Quan , Dubrovska Anna , Biroc Sandra L. , Marsden Robin , Pinstaff Jason , Smider Vaughn V. , Schultz Peter G. 
Published: October 2013

SignificanceWe have developed a semisynthetic method for the production of bispecific antibody-like therapeutics consisting of a small molecule targeting moiety conjugated to an antibody. A highly selective prostate-specific membrane antigen-binding ligand was site specifically conjugated to a mutant α cluster of differentiation 3 (αCD3) Fab containing an unnatural amino acid with orthogonal chemical reactivity. The optimized conjugate showed potent in vitro activity, good serum half-life, and potent in vivo activity in prostate cancer xenograft mouse models. This semisynthetic approach is likely to be applicable to the generation of additional bispecific agents using drug-like ligands selective for other cell-surface receptors.
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
Authors: Sugiyama Daisuke , Nishikawa Hiroyoshi , Maeda Yuka , Nishioka Megumi , Tanemura Atsushi , Katayama Ichiro , Ezoe Sachiko , Kanakura Yuzuru , Sato Eiichi , Fukumori Yasuo , Karbach Julia , Jäger Elke , Sakaguchi Shimon 
Published: October 2013

SignificanceRegulatory T (Treg) cells expressing the transcription factor FOXP3 play a critical role in suppressing antitumor immune responses. Here we found that, compared with peripheral blood T cells, tumor-infiltrating T cells contained a higher frequency of effector Tregs, which are defined as FOXP3hiand CD45RA−, terminally differentiated, and most suppressive. Effector Treg cells, but not FOXP3loand CD45RA+naïve Treg cells, predominantly expressed C-C chemokine receptor 4 (CCR4) in both cancer tissues and peripheral blood. In vivo or in vitro anti-CCR4 mAb treatment selectively depleted effector Treg cells and efficiently induced tumor-antigen-specific CD4+and CD8+T cells. Thus, cell-depleting anti-CCR4 mAb therapy is instrumental for evoking and enhancing tumor immunity in humans via selectively removing effector-type FOXP3+Treg cells.
MDMX contains an autoinhibitory sequence element
Authors: Bista Michal , Petrovich Miriana , Fersht Alan R. 
Published: October 2013

Significance
The protein MDMX is an important negative regulator of the tumor suppressor p53 in normal cells and can become a powerful oncogene. Previous studies on isolated protein fragments established that the N-terminal domain of MDMX binds tightly to the N-terminal domain of p53 and inhibits it. We now find that full-length MDMX contains a regulatory element (the “WWW element”) that binds to its own N-terminal domain and prevents MDMX from binding to p53. This autoinhibition introduces a new level of regulation of MDMX, whereby accessory proteins may sequester the WWW sequence and reactivate MDMX, and may explain why a variant of MDMX that lacks the WWW sequence, which is found in some cancer cells, might be oncogenic.
MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9
Authors: Chai Sunghee , Cambronne Xiaolu A. , Eichhorn Stephen W. , Goodman Richard H. 
Published: October 2013

Significance
Most brain regions comprise numerous neural cell types that are distinct in function and molecular characteristics. We examined microRNA-134 (miR-134) activity in cortical cultures using a microRNA sensor and discovered that miR-134 was induced in response to neuronal activity in somatostatin- and calretinin-expressing interneurons but not in pyramidal neurons. We identified the palmitoylation enzyme DHHC9 as a direct target of miR-134 and showed that it contributed to the regulation of H-Ras in somatostatin interneurons. H-Ras is a signaling molecule crucial for neuronal development and function. This study uncovered an activity-dependent miR-134 regulatory pathway in cortical interneurons that can potentially affect membrane localization of multiple signaling molecules.
Ecological value of coastal habitats for commercially and ecologically important species
Authors: Seitz Rochelle D. , Wennhage Håkan , Bergström Ulf , Lipcius Romuald N. , Ysebaert Tom 
Published: October 2013

AbstractMany exploited fish and macroinvertebrates that utilize the coastal zone have declined, and the causes of these declines, apart from overfishing, remain largely unresolved. Degradation of essential habitats has resulted in habitats that are no longer adequate to fulfil nursery, feeding, or reproductive functions, yet the degree to which coastal habitats are important for exploited species has not been quantified. Thus, we reviewed and synthesized literature on the ecological value of coastal habitats (i.e. seagrass beds, shallow subtidal and intertidal habitats, kelp beds, shallow open water habitats, saltmarshes, mussel beds, macroalgal beds, rocky bottom, and mariculture beds) as feeding grounds, nursery areas, spawning areas, and migration routes of 59 taxa, for which the International Council for the Exploration of the Sea (ICES) gives management advice, and another 12 commercially or ecologically important species. In addition, we provide detailed information on coastal habitat use for plaice (Pleuronectes platessa), cod (Gadus morhua), brown shrimp (Crangon crangon), and European lobster (Homarus gammarus). Collectively, 44% of all ICES species utilized coastal habitats, and these stocks contributed 77% of the commercial landings of ICES-advice species, indicating that coastal habitats are critical to population persistence and fishery yield of ICES species. These findings will aid in defining key habitats for protection and restoration and provide baseline information needed to define knowledge gaps for quantifying the habitat value for exploited fish and invertebrates.
Ethylenediammonium sodium tetrakis[bis(ethylenediamine-κ2N,N′)(oxalato-κ2O1,O2)cobalt(III)] [pentahydrogen di(phosphatooctadecatungstate)] tetradecahydrate
Authors: Zhang Shuzhuo , Wang Jing , Xu Yun 
Published: October 2013

The title compound, Na(C2H10N2)[Co(C2O4)(C2H8N2)2]4[H5(P2W18O62)2]·14H2O, prepared under hydrothermal conditions, consists of two Dawson-type [P2W18O62]6−anions, four isolated [Co(en)2(ox)]+cations (en = ethylenediamine and ox = oxalate), one Na+cation, one [H2en]2+cation, and a number of ordered (14) and disordered solvent water molecules. The [P2W18O62]6−polyoxidometalate anion has site symmetry 1 and contains two structurally distinct types of W atoms:viz.six W atoms on vertical pseudo-mirror planes grouped in two sets of three, and 12 equatorial W atoms that do not lie in the pseudo-mirror planes grouped in two sets of six. In each [Co(en)2(ox)]+cation, the CoIIIion is coordinated by four N atoms from two en ligands and two O atoms from the ox ligands, completing a distorted octahedral structure. The sodium cation lies on an inversion centre and additionally links the complex cations and anions. In the crystal, the various units are linked by N—H...O and O—H...O hydrogen bonds, which together with C—H...O hydrogen bonds form a three-dimensional structure. The contribution of a region of disordered electron density, possibly highly disordered solvent water molecules, to the scattering was removed with the SQUEEZE option ofPLATON[Spek (2009).Acta Cryst.D65, 148–155]. To equilibrate the charges five H+ions have been added to the polyoxidometalate. These H+ions and the disordered solvent contribution were not included in the reported molecular weight and density.
Remuneration committee independence and CEO remuneration for firm financial performance
Authors: Cybinski Patti , Windsor Carolyn 
Published: October 2013

Purpose– As a result of the Australian Government Productivity Commission's recommendation to mandate remuneration committee independence for ASX300 companies, this study aims to investigate whether voluntary remuneration committee independence aligns chief executive officer (CEO) total pay and bonuses with firm financial performance.Design/methodology/approach– A series of hypotheses test the research question using multiple regressions for a sample of 143 ASX300 companies during 2001. This time was prior to strengthen corporate governance regulation, but after mandated executive remuneration disclosure, thus capturing varying levels of voluntary remuneration committee independence.Findings– This study shows firm size is an influential factor in the relationship under investigation. ASX300 large firm remuneration committees link CEO total remuneration and bonuses to firm financial performance. Smaller ASX firm remuneration committees do not link either type of CEO remuneration to performance despite remuneration committee independence. Findings are mixed for medium-sized ASX300 firms.Research limitations/implications– Limitations include the necessary time restriction to 2001 for sampling the ASX300 firms. The implication of this study's findings is that the proposed public policy for mandatory remuneration committee independence is not universally effective in linking CEO remuneration to firm financial performance for ASX300 firms.Originality/value– This study contributes to the limited research on voluntary remuneration committee independence in relation to CEO remuneration and firm financial performance in the Australian context.
Coincident and forecast relevance of accounting numbers
Authors: Marek Klimczak Karol , Szafranski Grzegorz 
Published: October 2013

Purpose
– Value relevance studies, in particular international comparative studies, use market values sampled at different dates relative to the fiscal year-end. This paper aims to contribute a theoretical and empirical analysis of the relationship between value relevance and the month of market value sampling.

Design/methodology/approach
– The paper examines two components of value relevance, coincident relevance and forecast relevance, which the paper develops on the basis of the Ohlson model. The paper measures value relevance by estimating separate panel-data regressions for each of the 12 months around fiscal year-end. The sample consists of companies listed in two continental European countries, France and Germany, over the 1989-2008 period.

Findings
– In both country panels, the paper finds that overall value relevance is higher when market value is sampled before or close to fiscal year-end, but incremental value relevance varies between domestic and International Financial Reporting (IFRS) accounting standards. Regression results reveal significant variations in coefficients over the following months of market value in French panel and its IFRS sub-sample only.

Research limitations/implications
– The scope of the study is limited to the average value relevance parameters of companies listed on stock exchanges in France and Germany. Future research may be devoted to other countries and study additional determinants of value relevance.

Practical implications
– The study shows that the selection of the month of market value sampling can have significant impact on value relevance regression results. Therefore, sensitivity analysis needs to be included in research studies which rely on the value relevance approach.

Originality/value
– The paper contributes the first systematic analysis of the variation in value relevance parameters in response to the selection of the month in which market value is sampled.
Re-visiting the supply chain: a communication perspective
Authors: C. Gambetti Rossella , Giovanardi Mattia 
Published: October 2013

Purpose– This study is aimed at revisiting the supply chain (SC) of a company, highlighting how communication supports SC management, emphasising how SC relationship-based processes are fostered by communication flows, and exploring how SC performance may be enhanced through coordinated management of interpersonal and internet-mediated communication forms.Design/methodology/approach– The study follows a two-step qualitative methodological approach encompassing the building of a preliminary conceptual mapping, and preliminary testing, integration and revision of the conceptual mapping.Findings– The findings highlight communication's primary role in identity management and image building of the SC, and its supporting role enhancing strategic and operational SC processes. Communication seems to act as a “cultural glue”, a “trade-off and compensation”, a “knowledge creation and dissemination”, a “relationship development and maintenance”, and an “alignment and integration” activity along the SC, fostering knowledge, managerial, relational and competitive SC performance dimensions.Practical implications– The combination of SC and corporate communication academic knowledge with field SC managerial expertise allows the proposal of a preliminary conceptual framework illustrating the potential links among SC processes, communication and SC performance. The study provides also a set of research propositions to guide both future research and managerial practice in communication management along the SC.Originality/value– This study offers a first exploratory “communicational view” of the SC, which beyond analysing communication in the corporate locus of the typical communication function explores the value of communication that is embedded in manufacturing processes and routines at the basis of corporate performance by developing a cross-functional communication approach.
Enhancing access to library resources at Northern Caribbean University through an e-library initiative
Authors: Knight Natalee 
Published: October 2013

Purpose
– The purpose of this paper was to examine the impact of the e-library on the usage of library resources at Northern Caribbean University. The objective was also to determine whether or not it is worthwhile to continue to invest in electronic resources in a period of declining library budgets and easy access to electronic resources via the internet.

Design/methodology/approach
– Data were collected from library statistical reports as well as from a survey administered to students and faculty on both the main and extension campuses over a four-week period. The population studied in the survey was 280 faculty members and 5,340 students. Of this number, a stratified random sample of 50 faculty members and 200 students was selected.

Findings
– The study shows that the provision of e-library resources has increased overall usage of library materials as patrons continue to use print resources in tandem with electronic versions. The study also found that the electronic library resources are helpful to patrons and play an important role in enhancing access to library resources necessary for quality research papers and academic excellence on a whole.

Originality/value
– It is hoped that the findings of this paper will serve to assist the librarians and faculty at Northern Caribbean University and other similar institutions in selecting and acquiring the most appropriate format of information resources that will both satisfy the needs of their library users and fit within their library budget. Recommendations for improving the e-library service include continuous collaboration between librarians and faculty in selecting and acquiring the most appropriate format of resources to support the curriculum and satisfy the users' needs, constant marketing of the resources and on-going training in their use, and periodic assessment of the collection to ensure quality and competitiveness in light of other readily available electronic resources on the internet.
Use of social networks for academic purposes: a case study
Authors: Nández Gemma , Borrego Ángel 
Published: October 2013

Purpose
– This paper aims to analyse various aspects of an academic social network: the profile of users, the reasons for its use, its perceived benefits and the use of other social media for scholarly purposes.

Design/methodology/approach
– The authors examined the profiles of the users of an academic social network. The users were affiliated with 12 universities. The following were recorded for each user: sex, the number of documents uploaded, the number of followers, and the number of people being followed. In addition, a survey was sent to the individuals who had an email address in their profile.

Findings
– Half of the users of the social network were academics and a third were PhD students. Social sciences scholars accounted for nearly half of all users. Academics used the service to get in touch with other scholars, disseminate research results and follow other scholars. Other widely employed social media included citation indexes, document creation, edition and sharing tools and communication tools. Users complained about the lack of support for the utilisation of these tools.

Research limitations/implications
– The results are based on a single case study.

Originality/value
– This study provides new insights on the impact of social media in academic contexts by analysing the user profiles and benefits of a social network service that is specifically targeted at the academic community.
Web of Science, Scopus and Google Scholar
Authors: S. Adriaanse Leslie , Rensleigh Chris 
Published: October 2013

Purpose– The research aim for this study was to compare three citation resources with one another to identify the citation resource with the most representative South African scholarly environmental sciences citation coverage. This paper focuses on the results of the content verification process which measured amongst others the citation counts, multiple copies and inconsistencies encountered across the three citation resources ISI Web of Science, Scopus and Google Scholar.Design/methodology/approach– The research, the first phase of a longitudinal study, used a comparative research design method with a purposive, non-probability sample. Data from the South African scholarly environmental sciences journals for the year range 2004-2008 (first phase) were extracted from the three citation resources and compared.Findings– It became evident during the verification process that the citation resources retrieved varied results. The total citation counts indicated that ISI Web of Science (WOS) retrieved the most citation results, followed by Google Scholar (GS) and then Scopus. WOS performed the best with total coverage of the journal sample population and also retrieved the most unique items. The investigation into multiple copies indicated that WOS and Scopus retrieved no duplicates, while GS retrieved multiple copies. Scopus delivered the least inconsistencies regarding content verification and content quality compared to the other two citation resources. Additionally, GS also retrieved the most inconsistencies, with WOS retrieving more inconsistencies than Scopus. Examples of these inconsistencies include author spelling and sequence, volume and issue number.Originality/value– The findings of the study contribute to the understanding of the completeness of citation results retrieved from different citation resources. In addition it will raise awareness amongst academics to check citations of their work.
Technological foresight model for the identification of business opportunities (TEFMIBO)
Authors: Güemes Castorena David , Romero Rivera Geovanny , Villarreal González Amado 
Published: October 2013

Purpose
– The objective of this study is to provide a support tool for managers to identify future business opportunities.

Design/methodology/approach
– The proposed model consists of eight-steps. For the first step the authors propose two studies: trends analysis and change drivers' identification; these help to identify the most relevant trends in areas that may affect the business activities. All this information is put into a Delphi process with the help of experts in order to find the common denominator of where the future is going; afterwards, with this information, the authors can build events and scenarios for the business opportunities. Then, a diagnostic of the study area, sector or organization through the dynamic diagnostic methods is performed.

Findings
– Once the opportunities have been identified, a strategic analysis that allows decision making to prioritize and define the activities or projects that may be achievable in the future is done, and the result of the process is a portfolio of business opportunities projects fully defined and ready to be planned with a roadmap.

Originality/value
– The proposed model allows the managers to consistently organize their development processes targeted to real business opportunities.
Bibliometrics-based foresight on renewable energy production
Authors: Paananen Aija , J. Mäkinen Saku 
Published: October 2013

Purpose
– The purpose of this study is to investigate whether news media as a form of social communication regarding pressing, important, and contemporary issues could be used as a leading indicator of technology adoption. For technology foresight, monitoring and analyzing energy technologies is in the spotlight due to their strategic importance to the agenda of competitive and sustainable economic growth.

Design/methodology/approach
– The trends in renewable energy production and news media are determined and compared to draw inferences in foresight concerning the use of renewable energy technologies in energy production. Consequently, the data concern wind and solar energy production and their representation in news media in Germany and the UK. The analysis proceeds as a quasi-experiment treating each yearly observation of energy production as a function of news media data with lagged variables.

Findings
– The study reveals consistent dynamics in the lag in the primary production of energy in related technologies compared to the media visibility of the respective technologies.

Originality/value
– This study explores the prospects of using news media data in foresight analysis concerning renewable energy production and provides many fruitful avenues for foresight research in investigating relationships between technology adoption and media exposure.
Customer segmentation based on buying and returning behaviour
Authors: Hjort Klas , Lantz Björn , Ericsson Dag , Gattorna John 
Published: October 2013

Purpose
– The purpose of this paper is twofold: first, to empirically test whether a “one size fits all” strategy fits the fashion e-commerce business and second, to evaluate whether consumer returns are a central aspect of the creation of profitability and, if so, to discuss the role of returns management (RM) in the supply chain strategy.

Design/methodology/approach
– Transactional sales and return data were analysed and used to categorise customers based on their buying and returning behaviours, measuring each customer's net contribution margins.

Findings
– The e-commerce business collects a vast quantity of data, but these data are seldom used for the development of service differentiation. This study analysed behaviour patterns and determined that the segmentation of customers on the basis of both sales and return patterns can facilitate a differentiated service delivery approach.

Research limitations/implications
– This research empirically supports the theory that customer buying and returning behaviours can be used to appropriately categorise customers and thereby guide the development of a more differentiated service approach.

Practical implications
– The findings support a differentiated service delivery system that utilises a more dynamic approach, conserving resources and linking the supply chain and/or organisational strategies with customers' buying and returning behaviours to avoid over and underservicing customers.

Originality/value
– Consumer returns are often viewed as a negative aspect of doing business; interestingly, however, the authors revealed that the most profitable customer is a repeat customer who frequently returns goods.