bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of FDA‐approved drugs that target hepatitis B virus transcription
Authors: van de Klundert M. A. A. , Zaaijer H. L. , Kootstra N. A. 
Published: October 2015

SummaryIn the treatment of chronic hepatitis B virus (HBV) infection, polymerase inhibitors successfully suppress HBV DNA production. However, the production of viral proteins continues unhindered, which hampers viral clearance. Here, we screen for compounds that suppress HBV transcription, which would prevent viral protein production. A total of 640 FDA‐approved drugs were evaluated for their ability to inhibit HBV transcription in a transfection‐based HBV reporter assay. The assay was performed in the presence and absence of the HBV accessory protein X (HBx), which is essential for in vivo HBV RNA transcription. We observed that in the absence of HBx 47, and in the presence of HBx 24 compounds suppressed transcription by more than 20%. We selected the 24 most potent compounds in each condition for further analysis. On average, the selected compounds reduced transcription by 33.9% (range: 24.1–65.8%) in the absence of HBx expression, and 30.6% (range: 20.4–48.9%) in the presence of HBx. The two selections of 24 compounds had 12 compounds in common, resulting in a final selection of 36 compounds, which were evaluated for their capacity to suppress HBV replication in constitutively HBV‐replicating HepG2.2.15 cells. Twenty‐three of these compounds reduced HBV replication by interfering with RNA transcription. Further analysis revealed that one of the compounds, terbinafine, potently and specifically suppressed HBx‐mediated HBV RNA transcription in HepG2 cells. Inhibition of HBV protein production is a promising step towards HBV clearance. In combination with an HBV polymerase inhibitor, the added suppression of HBV RNA transcription may markedly improve antiviral treatment outcome.
The influence of boulder shape on the spatial distribution of crustose coralline algae (Corallinales, Rhodophyta)
Authors: Liversage Kiran 
Published: October 2015

AbstractStudies investigating the many ecologically and economically important species in benthic boulder habitats often use artificial boulders for determining species colonization. In some cases square‐edged blocks are used that are shaped much differently than the ovoid or ‘round’ boulders often occurring naturally. Here it was tested if the shape of boulders affects the distribution across the boulder surface of crustose coralline algae (CCA), a taxon that strongly influences ecological dynamics in this habitat. The distance that CCA extends from the edge of boulders toward the centre of the underside was measured, and it was found that CCA extended further underneath boulders that were round‐shaped compared with those that were block‐shaped, probably because of light reaching further underneath round boulders. This result shows how at least one important taxon can be affected by variation in the shape of these boulders. Hypotheses being tested that use artificial substrata to model naturally occurring boulders should be carried out only in places where the artificial and naturally occurring boulders match physically.
Fine‐scale kin recognition in the absence of social familiarity in the Siberian jay, a monogamous bird species
Authors: Griesser Michael , Halvarsson Peter , Drobniak Szymon M. , Vilà Carles 
Published: October 2015

AbstractKin recognition is a critical element to kin cooperation, and in vertebrates, it is primarily based on associative learning. Recognition of socially unfamiliar kin occurs rarely, and it is reported only in vertebrate species where promiscuity prevents recognition of first‐order relatives. However, it is unknown whether the recognition of socially unfamiliar kin can evolve in monogamous species. Here, we investigate whether genetic relatedness modulates aggression among group members in Siberian jays (Perisoreus infaustus). This bird species is genetically and socially monogamous and lives in groups that are formed through the retention of offspring beyond independence, and the immigration of socially unfamiliar nonbreeders. Observations on feeders showed that genetic relatedness modulated aggression of breeders towards immigrants in a graded manner, in that they chased most intensely the immigrant group members that were genetically the least related. However, cross‐fostering experiments showed that breeders were equally tolerant towards their own and cross‐fostered young swapped as nestlings. Thus, breeders seem to use different mechanisms to recognize socially unfamiliar individuals and own offspring. As Siberian jays show a high degree of nepotism during foraging and predator encounters, inclusive fitness benefits may play a role for the evolution of fine‐scale kin recognition. More generally, our results suggest that fine‐graded kin recognition can evolve independently of social familiarity, highlighting the evolutionary importance of kin recognition for social species.
Temporal genetic analysis of the endangered tidewater goby: extinction–colonization dynamics or drift in isolation?
Authors: Kinziger Andrew P. , Hellmair Michael , McCraney W. Tyler , Jacobs David K. , Goldsmith Greg 
Published: October 2015

AbstractExtinction and colonization dynamics are critical to understanding the evolution and conservation of metapopulations. However, traditional field studies of extinction–colonization are potentially fraught with detection bias and have rarely been validated. Here, we provide a comparison of molecular and field‐based approaches for assessment of the extinction–colonization dynamics of tidewater goby (Eucyclogobius newberryi) in northern California. Our analysis of temporal genetic variation across 14 northern California tidewater goby populations failed to recover genetic change expected with extinction–colonization cycles. Similarly, analysis of site occupancy data from field studies (94 sites) indicated that extinction and colonization are very infrequent for our study populations. Comparison of the approaches indicated field data were subject to imperfect detection, and falsely implied extinction–colonization cycles in several instances. For northern California populations of tidewater goby, we interpret the strong genetic differentiation between populations and high degree of within‐site temporal stability as consistent with a model of drift in the absence of migration, at least over the past 20–30 years. Our findings show that tidewater goby exhibit different population structures across their geographic range (extinction–colonization dynamics in the south vs. drift in isolation in the north). For northern populations, natural dispersal is too infrequent to be considered a viable approach for recolonizing extirpated populations, suggesting that species recovery will likely depend on artificial translocation in this region. More broadly, this work illustrates that temporal genetic analysis can be used in combination with field data to strengthen inference of extinction–colonization dynamics or as a stand‐alone tool when field data are lacking.
Rorty's Debt to Sellarsian Metaphysics
Authors: Sachs Carl B. 
Published: October 2015

AbstractRorty regards himself as furthering the project of the Enlightenment by separating Enlightenment liberalism from Enlightenment rationalism. To do so, he rejects the very need for explicit metaphysical theorizing. Yet his commitments to naturalism, nominalism, and the irreducibility of the normative come from the metaphysics of Wilfrid Sellars. Rorty's debt to Sellars is concealed by his use of Davidsonian arguments against the scheme/content distinction and the nonsemantic concept of truth. The Davidsonian arguments are used for Deweyan ends: to advance secularization and anti‐authoritarianism. However, Rorty's conflation of theology and metaphysics conceals the possibility of post‐theological metaphysics. The key distinction lies between “metaphysics” and “Metaphysics.” The former provisionally models the relations between different vocabularies; the latter continues theology by other means. Sellars shows how to do metaphysics without Metaphysics. This approach complements Rorty's prioritization of cultural politics over ontology and his vision of Enlightenment liberalism without Enlightenment rationalism.
The Roots and Achievements of the Early Proto‐Sunni Movement: A Profile and Interpretation
Authors: Kuiper Matthew J. 
Published: October 2015

AbstractIn recent years, the term “proto‐Sunni” has become common in scholarship on the early centuries of Islam. Drawing on categories developed by Peter Berger, this study seeks to move toward a more inclusive portrait of the early proto‐Sunni movement and a more organic understanding of the movement's success. It argues that owing to the erosion of several of the “plausibility structures” of earliest Islam, three tendencies emerged among the proto‐Sunnis between the early 8th and mid‐9th centuries C.E.: proto‐Sunnis as traditionist ῾ulamā᾽, proto‐Sunnis as pious ascetics, and proto‐Sunnis as volunteer holy warriors. The prestige acquired through their activities in these areas enabled the early proto‐Sunnis to “objectify” and “legitimize” new plausibility structures which would prove decisive to an eventual Sunni consensus.
New fossil Hyaenodonta (Mammalia, Placentalia) from the Ypresian and Lutetian of France and the evolution of the Proviverrinae in southern Europe
Authors: Solé Floréal , Falconnet Jocelyn , Vidalenc Dominique 
Published: October 2015

AbstractThe proviverrines from the Ypresian (MP7–MP10) and Lutetian (MP11–MP14) are represented mainly by species recorded in the northern and central parts of Europe (Paris Basin, Belgian Basin, Germany, Switzerland). Here, we describe fossils from southern France: Saint‐Papoul (MP8 + 9; Aude) and Aigues‐Vives 2 (?MP13; Aude). One dentary with secant molars from Saint‐Papoul represents a new genus and species, Preregidens langebadrae. This taxon is possibly present in Avenay (France), the MP8 + 9 reference locality. One of the three dentaries discovered in Aigues‐Vives 2 belongs to the hypercarnivorous Oxyaenoides schlosseri, previously represented by only two isolated lower molars. This dentary appears to be the most derived of the proviverrines. This species is possibly present in Saint‐Martin‐de‐Londres (France), a locality that is considered to be close to the MP13 reference level. The two other dentaries from Aigues‐Vives 2 support the presence of Eurotherium theriodis and provide the first possible evidence of sexual dimorphism in a proviverrine species. A phylogenetic analysis of the proviverrines is performed to resolve the phylogenetic position of the three taxa. This identifies a close relationship between the new genus (Preregidens) and Oxyaenoides. The new fossils allow the age of Saint‐Papoul and Aigues‐Vives 2 to be refined: the first locality is considered to be close in age to Avenay (Ypresian; France), while the second one seems to be close to Egerkingen γ (Lutetian; Switzerland), which is considered to be possibly close in age to the MP13 reference level. Finally, the presence of O. schlosseri and E. theriodis in the southern part of France is compatible with the hypothesis that the mammals involved in the first intra‐Eocene turnover migrated northwards.
Orthotopic heart transplantation in two infants with histiocytoid cardiomyopathy and left ventricular non‐compaction
Authors: Siehr Stephanie L. , Bernstein Daniel , Yeh Justin , Berry Gerald J. , Rosenthal David N. , Hollander Seth A. 
Published: October 2015

AbstractHC is a rare cause of congestive heart failure that typically presents with malignant ventricular arrhythmias in infants, often requiring urgent intervention. Successful heart transplantation in a patient with HC has only been reported once (J Heart Lung Transplant 2004: 23: 902). The combination of HC with concurrent LVNC has only been described three times (Int J Legal Med 2009: 123: 47; Hum Pathol 2005: 36: 403; Pediatr Dev Pathol 2012: 15: 397). We report two rare cases of HC with LVNC in two infants presenting with cardiogenic shock, one requiring ECMO support who was successfully bridged to orthotopic heart transplantation with a Berlin Heart LVAD.
Paraphrase Strategies in Metaphysics
Authors: von Solodkoff Tatjana 
Published: October 2015

AbstractPhilosophers often aim to demonstrate that the things we ordinarily think and say can be reconciled with our considered beliefs about the world. To this end, many philosophers try to paraphrase ordinary language claims by finding equivalent sentences that are less misleading. For instance, though we know that there is no British family that is the average one, we want to say that the average British family has 1.8 children, and we might do that by paraphrasing this claim as: there are nearly twice as many British children as British families. This article aims to introduce and distinguish different paraphrase strategies, sketch their role in metaphysical debates and highlight some crucial questions that proponents of such strategies face.
Suppression of net transpiration by multiple mechanisms conserves water resources during pupal diapause in the corn earworm Helicoverpa zea
Authors: Benoit Joshua B. , Zhang Qirui , Jennings Emily C. , Rosendale Andrew J. , Denlinger David L. 
Published: October 2015

AbstractOne critical aspect of an insect's ability to overwinter successfully is the effective management of its water resources. Maintenance of adequate water levels during winter is challenging because of the prevailing low relative humidity at that time of year and the short supply of environmental water that is not in the form of ice. These issues are further exacerbated for insects overwintering as pupae, comprising an immobile stage that is unable to move to new microhabitats if conditions deteriorate. The present study compares the water balance attributes of diapausing and nondiapausing pupae of the corn earworm Helicoverpa zea Boddie, aiming to identify the mechanisms used by diapausing pupae to maintain water balance during winter. Diapausing pupae are 10% larger than nondiapausing individuals. Water loss rates for nondiapausing pupae are low (0.21 mg h−1) and are suppressed (0.01 mg h−1) in diapausing pupae. Cuticular lipids, which serve to waterproof the cuticle and thus suppress cuticular water loss, are more than two‐fold more abundant on the surface of diapausing pupae, and oxygen consumption rates during diapause drop to almost one‐third the rate observed in nondiapausing pupae. Water gain can be accomplished only when atmospheric water content is near saturation or during contact with free water. At moderate relative humidities (20–40%), water loss rates are very low for diapausing pupae, suggesting that these moth pupae have robust mechanisms for combating water loss. The exceptional ability of H. zea to suppress water loss during diapause is probably a result of the combined effects of increased size, more abundant cuticular lipids and decreased metabolic rates.
Which Mental States Are Rationally Evaluable, And Why?
Authors: Nolfi Kate 
Published: October 2015

AbstractWhat makes certain mental states subject to evaluation with respect to norms of rationality and justification, and others arational? In this paper, I develop and defend an account that explains why belief is governed by, and so appropriately subject to, evaluation with respect to norms of rationality and justification, one that does justice to the complexity of our evaluative practice in this domain. Then, I sketch out a way of extending the account to explain when and why other kinds of mental states are rationally evaluable. I argue that the cognitive or psychological mechanisms that give rise to and sustain our mental states help to render our mental states appropriate targets for evaluation with respect to norms of rationality and justification when the operation of these mechanisms is responsive, in a specific way, to our judgments about which kinds of considerations constitute rationalizing and justifying reasons for being in states of the relevant sort.
Immunomodulatory effects of adult Haemonchus contortus excretory/secretory products on human monocyte‐derived dendritic cells
Authors: Rehman Z. U. , Knight J. S. , Koolaard J. , Simpson H. V. , Pernthaner A. 
Published: October 2015

SummaryThe levels of expression of surface molecules and release of cytokines and chemokines of human monocyte‐derived dendritic cells were determined after their exposure to adult H. contortus excretory/secretory (ES) products or a combination of ES products and bacterial lipopolysaccharide (LPS). Worm products provoked a weak response and only partial maturation of the dendritic cells, consistent with the hyporesponsiveness and more tolerogenic immune environment present in parasitized animals and humans. Co‐stimulation with LPS demonstrated that H. contortus secretions, like those of other helminths, contain immunomodulators capable of reducing some aspects of the strong TH1/TH2 response evoked by bacterial LPS. There were significant reductions in the release of some cytokine/chemokines by LPS‐stimulated mdDCs and a trend (although not significant at P < 0·05) for reduced expression levels of CD40, CD80 and HLA‐DR. A prominent feature was the variability in responses of dendritic cells from the four donors, even on different days in repeat experiments, suggesting that generalized conclusions may be difficult to make, except in genetically related animals. Such observations may therefore be applicable only to restricted populations. In addition, previous exposure to parasites in a target population for immunomodulatory therapy may be an important factor in assessing the likelihood of adverse reactions or failures in the treatment to worm therapy.
A Case for Supreme Court Term Limits? The Changing Ideological Relationship between Appointing Presidents and Supreme Court Justices
Authors: Sharma Hemant , Glennon Colin 
Published: October 2015

The desirability of complete judicial independence has been debated in several recent works. At issue is whether democratic theory is compatible with policy making by the unelected U.S. Supreme Court justices, particularly as their service becomes further removed from the time when elected officials played a role in their appointment. We examine the relationship between appointing presidents and Supreme Court justices. Relying on ideal points that place all actors in the same scale, our regression models show that a justice will drift from the ideology of an appointing president with each additional term served, even after controlling for ideological shifts in political climate. The beginning of the eleventh term is when ideological drift becomes significant. The connection between justices and democratically elected officials begins to wane after this point in a justice's tenure—a finding that is likely to be germane for proponents of term limits for Supreme Court justices.Related Articles
Sharma, Hemant, and John M. Scheb II. 2011. “.” Politics & Policy 39 (): 1077‐1105. http://onlinelibrary.wiley.com/doi/10.1111/j.1747‐1346.2011.00325.x/abstract

Basabe‐Serrano, Santiago. 2012. “.” Politics & Policy 40 (): 339‐361. http://onlinelibrary.wiley.com/doi/10.1111/j.1747‐1346.2012.00348.x/abstract

McCall, Madhavi. 2003. “.” Politics & Policy 31 (): 314‐343, http://onlinelibrary.wiley.com/doi/10.1111/j.1747‐1346.2003.tb00151.x/abstract
Related MediaThe Judicial Common Space: http://epstein.usc.edu/research/JCS.html
The American Presidency Project. 2013. http://www.presidency.ucsb.edu/

Greene, Jamal. 2012. “.” . July 8. http://www.nytimes.com/roomfordebate/2012/07/08/another‐stab‐at‐the‐us‐constitution/revisiting‐the‐constitution‐we‐need‐term‐limits‐for‐federal‐judges
The Current Status and Future Direction of Nanotechnology Regulations: A View from Nano‐scientists
Authors: Corley Elizabeth A. , Kim Youngjae , Scheufele Dietram A. 
Published: October 2015

AbstractThis article presents an up‐to‐date view of leading U.S. nanoscientists' perceptions about the regulation of nanotechnology. Our analysis draws from the results of a 2011 mail survey with 444 of the most prolific nanoscientists in the United States to explore their perceptions about existing nanotech policies, the development of new nanotech policies, and mandatory policies about the implementation of safe lab practices for federally funded nanoresearch. In addition to exploring the scientists' perceptions about these pressing policy issues, we also test relationships between their perceptions about regulation and control variables such as gender, disciplinary affiliation, and political ideology. Last, the results of the 2011 data collection are compared with a similar mail survey that was conducted in 2007 with leading U.S. nanoscientists to explore any changes over the four‐year time period in scientists' perceptions about nanotechnology policy making, and governmental involvement in nanotechnology research.
Hidden Second‐order Stationary Spatial Point Processes
Authors: Hahn Ute , Vedel Jensen Eva B. 
Published: October 2015

AbstractIn the existing statistical literature, the almost default choice for inference on inhomogeneous point processes is the most well‐known model class for inhomogeneous point processes: reweighted second‐order stationary processes. In particular, theK‐function related to this type of inhomogeneity is presented astheinhomogeneousK‐function. In the present paper, we put a number of inhomogeneous model classes (including the class of reweighted second‐order stationary processes) into the common general framework of hidden second‐order stationary processes, allowing for a transfer of statistical inference procedures for second‐order stationary processes based on summary statistics to each of these model classes for inhomogeneous point processes. In particular, a general method to test the hypothesis that a given point pattern can be ascribed to a specific inhomogeneous model class is developed. Using the new theoretical framework, we reanalyse three inhomogeneous point patterns that have earlier been analysed in the statistical literature and show that the conclusions concerning an appropriate model class must be revised for some of the point patterns.