bluuebunny/crossref_metadata_2025_split huggingface dataset:
On The Exact Controllability of Impulsive Fractional Semilinear Functional Differential Inclusions
Authors: Liu Zhenhai , Li Xiuwen 
Published: November 2014

AbstractIn this paper, we deal with the exact controllability for impulsive fractional semilinear functional differential inclusions in Hilbert spaces. Under suitable assumptions, the exact controllability of the control systems are formulated and proved. The main tools in our study rely on the fixed point theorem for multivalued maps due to Dhage associated with evolution systems.
Dynamic surface control design for the rotating stall and surge in an aeroengine compressor
Authors: Dong Wenhan , Shao Pengjie , Xie Wujie , Lin Yan , Sun Xiuxia 
Published: November 2014

AbstractA dynamic surface controller is proposed for the control of the rotating stall and surge of an aeroengine. The new control law is simpler than the backstepping method, which suffers from the problem of “explosion of terms.” The useful nonlinearities that would have been cancelled in a feedback linearizing design are retained in the proposed method. The same controller structure could be employed with or without measuring the rotating stall, and without obtaining the signal of rotating stall amplitude a priori. The design process based on Lyapunov tools and the simulations showed that with the proposed scheme, the boundedness of all signals of a closed‐loop system could be assured.
Pulmonary vascular development goes awry in congenital lung abnormalities
Authors: Kool Heleen , Mous Daphne , Tibboel Dick , de Klein Annelies , Rottier Robbert J. 
Published: November 2014

AbstractPulmonary vascular diseases of the newborn comprise a wide range of pathological conditions with developmental abnormalities in the pulmonary vasculature. Clinically, pulmonary arterial hypertension (PH) is characterized by persistent increased resistance of the vasculature and abnormal vascular response. The classification of PH is primarily based on clinical parameters instead of morphology and distinguishes five groups of PH. Congenital lung anomalies, such as alveolar capillary dysplasia (ACD) and PH associated with congenital diaphragmatic hernia (CDH), but also bronchopulmonary dysplasia (BPD), are classified in group three. Clearly, tight and correct regulation of pulmonary vascular development is crucial for normal lung development. Human and animal model systems have increased our knowledge and make it possible to identify and characterize affected pathways and study pivotal genes. Understanding of the normal development of the pulmonary vasculature will give new insights in the origin of the spectrum of rare diseases, such as CDH, ACD, and BPD, which render a significant clinical problem in neonatal intensive care units around the world. In this review, we describe normal pulmonary vascular development, and focus on four diseases of the newborn in which abnormal pulmonary vascular development play a critical role in morbidity and mortality. In the future perspective, we indicate the lines of research that seem to be very promising for elucidating the molecular pathways involved in the origin of congenital pulmonary vascular disease. Birth Defects Research (Part C) 102:343–358, 2014. © 2014 Wiley Periodicals, Inc.
Mechanical stability analysis of the protein L immunoglobulin‐binding domain by full alanine screening using molecular dynamics simulations
Authors: Glyakina Anna V. , Likhachev Ilya V. , Balabaev Nikolay K. , Galzitskaya Oxana V. 
Published: November 2014

AbstractThis article is the first to study the mechanical properties of the immunoglobulin‐binding domain of protein L (referred to as protein L) and its mutants at the atomic level. In the structure of protein L, each amino acid residue (except for alanines and glycines) was replaced sequentially by alanine. Thus, 49 mutants of protein L were obtained. The proteins were stretched at their termini at constant velocity using molecular dynamics simulations in water, i.e. by forced unfolding. 19 out of 49 mutations resulted in a large decrease of mechanical protein stability. These amino acids were affecting either the secondary structure (11 mutations) or loop structures (8 mutations) of protein L. Analysis of mechanical unfolding of the generated protein that has the same topology as protein L but consists of only alanines and glycines allows us to suggest that the mechanical stability of proteins, and specifically protein L, is determined by interactions between certain amino acid residues, although the unfolding pathway depends on the protein topology. This insight can now be used to modulate the mechanical properties of proteins and their unfolding pathways in the desired direction for using them in various biochips, biosensors and biomaterials for medicine, industry, and household purposes.
Quantitation of VEGFR2 (vascular endothelial growth factor receptor) inhibitors – review of assay methodologies and perspectives
Authors: Sharma Kuldeep , Suresh P. S. , Mullangi Ramesh , Srinivas N. R. 
Published: November 2014

AbstractThe introduction of small‐molecule tyrosine kinase VEGFR2 (vascular endothelial growth factor receptor) inhibitors has added another dimension in the treatment of several oncology indications as they offer a unique mechanism. The VEGFR2 inhibitors have demonstrated superior benefits in treating certain types of cancer, such as renal cell carcinoma and hepatocellular carcinoma, as a monotherapy option. Many of the approved VEGFR2 inhibitors have also shown promise when used in combination with other anticancer agents. There are numerous bioanalytical methods published for the analysis of VEGFR2 inhibitors in preclinical and clinical samples. This review covers VEGFR2 inhibitors such as sunitinib, sorafenib, pazopanib and JI‐101. In addition to providing a comprehensive review of the available methods for the above‐mentioned VRGFR2 inhibitors, it also provides information on assays that can simultaneously measure multiple tyrosine kinase inhibitors, including VEGFR2 molecules. Based on the review, the published methodologies using LC/MS‐MS or HPLC‐UV are adequate for the quantification of the VEGFR2 inhibitors and can easily be established in a modern day bioanalytical laboratory. The availability of a plethora of assays for multiple tyrosine kinase inhibitors makes it easy to analyze a panel of compounds to support either therapeutic drug monitoring and/or clinical pharmacokinetics. Copyright © 2014 John Wiley & Sons, Ltd.
Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC‐MSn combined with specific inhibitors
Authors: Bi Yunfeng , Zhuang Xiaoyu , Zhu Hongbin , Song Fengrui , Liu Zhiqiang , Liu Shuying 
Published: November 2014

AbstractBulleyaconitine A (BLA) from Aconitum bulleyanum plants is usually used as anti‐inflammatory drug in some Asian countries. It has a variety of bioactivities, and at the same time some toxicities. Since the bioactivities and toxicities of BLA are closely related to its metabolism, the metabolites and the metabolic pathways of BLA in rat liver microsomes were investigated by HPLC–MSn. In this research, the 12 metabolites of BLA were identified according to the results of HPLC‐MSn data and the relevant literature. The results showed that there are multiple metabolites of BLA in rat liver microsomes, including demethylation, deacetylation, dehydrogenation deacetylation and hydroxylation. The major metabolic pathways of BLA in rat liver microsomes were clarified by HPLC‐MS combined with specific inhibitors of CYP450 isoforms. As a result, CYP3A and 2C were found to be the principal CYP isoforms contributing to the metabolism of BLA. Moreover, CYP2D6 and 2E1 are also more important CYP isoforms for the metabolism of BLA. While CYP1A2 only affected the formation rate of M11, its effect on the metabolism of BLA is very small. Copyright © 2014 John Wiley & Sons, Ltd.
Fast determination of virgin olive oil phenolic metabolites in human high‐density lipoproteins
Authors: Fernández‐Ávila C. , Montes R. , Castellote A. I. , Chisaguano A. M. , Fitó M. , Covas M. I. , Muñoz‐Aguallo D. , Nyyssönen K. , Zunft H. J. , López‐Sabater M. C. 
Published: November 2014

AbstractIn recent years it has been confirmed that the consumption of olive oil prevents the oxidation of biomolecules owing to its monounsaturated fatty acids (MUFA) and phenolic content. The main objective of the study was to develop an ultra‐high‐performance liquid chromatography (UHPLC) tandem mass spectrometry (MS/MS) method for the determination of phenolic compounds in human high‐density lipoprotein (HDL) samples. At the same time, the influence of olive oil consumption on the phenolic metabolite levels was evaluated in a European population. The participants were 51 healthy men, aged 20–60. They were randomized to two consecutive intervention periods with the administration of raw olive oil with low and high polyphenolic content. The UHPLC‐MS/MS analytical method has been validated for hydroxytyrosol and homovanillic acid in terms of linearity (r2 = 0.99 and 1.00), repeatability (5.7 and 6.5%) reproducibility (6.2 and 7%), recovery (98 to 97%), limits of detection (1.7 to 1.8 ppb) and quantification (5.8 and 6.3 ppb).The levels of the studied metabolites increased significantly after high polyphenolic content virgin olive oil ingestion (p <0.05) compared with lowpolyphenolic content olive oil. Virgin olive oil consumption increases the levels of phenolic metabolites in HDL and thus provides human HDL with more efficient antioxidant protection. Copyright © 2014 John Wiley & Sons, Ltd.
Effects of consumer embarrassment on shopping basket size and value: A study of the millennial consumer
Authors: Nichols Bridget Satinover , Raska David , Flint Daniel J. 
Published: November 2014

AbstractThis paper examines how the emotion of embarrassment affects shopping behavior in a retail setting. In a series of three studies, we explore the phenomenon of “masking,” which is defined as a coping strategy used by shoppers when experiencing embarrassment related to a purchase task. Study 1 provides consumer insights into masking behaviors among Millennials. Study 2 empirically examines degrees of anticipated embarrassment associated with purchasing a variety of personal care products and uses a controlled experiment to test the impact of embarrassment on the size of the shopping basket (number of items purchased) and the value of the shopping basket. Study 3 examines basket size and value with respect to complementary and counterbalancing products, and compares Millennial with non‐Millennial consumers. Collectively, this research indicates that both Millennial and non‐Millennials use masking as a coping strategy for a variety of products due to anticipated embarrassment, translating into enhanced basket sizes and values. This effect appears to be moderated by one's innate susceptibility to embarrassment. This study contributes to our understanding of how the emotion of embarrassment influences shopping basket composition in terms of its value and size. It also provides insightful findings relevant to retail practitioners. Copyright © 2014 John Wiley & Sons, Ltd.
Silver/Gold Core–Shell Nanoprism‐Based Plasmonic Nanoprobes for Highly Sensitive and Selective Detection of Hydrogen Sulfide
Authors: Yang Xinjian , Ren Yuqian , Gao Zhiqiang 
Published: November 2014

AbstractA simple and highly sensitive and selective hydrogen sulfide assay utilizing plasmonic nanoprobes is presented in this report. The assay employs the etching of silver in the Ag/Au core–shell nanoprisms, accompanied by surface plasmon resonance (SPR) signal depression and shift. Briefly, thin layers of gold are first coated onto silver nanoprisms. The thin gold layer not only guarantees the high stability of the plasmonic nanoprobes but also ensures the high selectivity toward hydrogen sulfide. Once hydrogen sulfide is introduced, the silver core is converted to Ag2S mainly from its lateral walls. Moreover, the SPR peak is located in the NIR region that makes these plasmonic nanoprobes more appealing for the detection of hydrogen sulfide in real‐world samples and in in vivo applications.
Preventive Effect of American Ginseng Against Premature Ovarian Failure in a Rat Model
Authors: Ge Pengling , Xing Nannan , Ren Yanhai , Zhu Lei , Han Dongwei , Kuang Haixue , Li Ji 
Published: November 2014

Abstract

Preclinical Research

Premature ovarian failure (POF) is defined by the WHO as the loss of physiological ovarian function before the age of 40. The effect of American ginseng and its underlying mechanisms in preventing and treating premature ovarian failure (POF) was studied in female Sprague‐Dawley rats where POF was induced by ip administration of 4‐vinylcyclohexene diepoxide (VCD). Rat behavior, serum hormone levels, ovarian and uterine size, pathological features, and ovarian tissue expression of genes associated with POF were assessed in controls, untreated POF model rats, and POF model rats treated with low‐ (1.125 g/kg), medium‐ (2.25 g/kg), and high‐dose (4.5 g/kg) American ginseng. Compared with untreated POF model rats, those treated with medium‐ and high‐dose American ginseng had more stable behavior and better coat appearance as well as serum hormone levels closer to those in control rats. Moreover, treatment with medium‐ or high‐dose American ginseng increased ovarian and uterine size. Hematoxylin and eosin‐staining revealed mature follicles and endometrium with an alternating concave/convex surface structure with visible capillaries and glands in ginseng‐ treated POF rats. PLA2G4A expression was positively correlated with POF, while the expression levels of PAPPA, STC2, CCL2, and NELL1 were negatively correlated with POF. Our study showed that American ginseng may effectively prevent POF and alleviate POF symptoms by regulating serum hormone levels and altering the expression levels of genes related to POF in ovarian tissue.
A Determination Method for the Optimal Operation of Controllable Generators in Micro Grids That Copes with Unstable Outputs of Renewable Energy Generation
Authors: Takano Hirotaka , Zhang Peng , Murata Junichi , Hashiguchi Takuhei , Goda Tadahiro , Iizaka Tatsuya , Nakanishi Yosuke 
Published: November 2014

SUMMARYMicro grids are expected to be one of the most realistic energy systems for efficient use of renewable energy sources with few adverse effects on the main electric power grids. However, it is difficult to maintain the supply‐and‐demand balance because distributed renewable energy generation units (DREGs), such as photovoltaic generation systems and wind turbine generation systems, generate a significant portion of electrical energy in the micro grids. Therefore, an operation planning method is needed considering the uncertainty in weather prediction in order to ensure stable micro grid operations. This paper presents an optimization method for operation plans of controllable generators in micro grids that copes with the uncertainty of DREG outputs. In the proposed method, the optimal operation plans are determined by, depending on the problem conditions, either an enumeration method or Tabu Search with preprocessing. Numerical simulations were carried out for a micro grid model in order to verify the usefulness of the proposed method. In the simulations, the daily operation plan and the modified half‐hourly one were determined by the proposed method. As a result, we could obtain the optimal plans which had enough reserve margins for coping with the fluctuations caused by DREGs and demand.
Photoactive Hybrid Polymer Films Incorporated with Lanthanide Complexes and ZIF‐8 for Selectively Excited Multicolored Luminescence
Authors: Liu Chang , Yan Bing 
Published: November 2014

AbstractA series of photoactive polymer hybrid films fabricated with both lanthanide complexes and ZIF‐8 [zeolite imidazole framework, a kind of metal organic framework, Zn(MeIM)2, MeIM = 2‐methylimidazole] was prepared. ZIF‐8 and the lanthanide complexes Ln‐L [Ln = Eu, Tb; L = AA (acetylacetonate), phen (1,10‐phenanthroline), TAA (trifluoroacetylacetonate), TTA (trifluoroacetylacetonate)] were assembled with the the monomers 4‐vinyl pyridine (VPD) and ethylene‐methyl acrylate (EMA), forming the final hybrid polymer films after initiation with benzoyl peroxide (BPO). The products are are indicated as PEMA‐PVPD⊃Ln‐L/ZIF‐8 [PEMA‐PVPD: copolymer of poly 4‐vinyl pyridine (PVPD) and polyethylene‐methyl acrylate (PEMA)]. The SEM images of these hybrid films indicate homogeneous dense packing and a high degree of coverage of the crystals on the ITO glass. The luminescent behavior of all the hybrid films was studied in detail. Discrete luminescence of the ZIF‐8 unit and the lanthanide complexes was observed in which energy coupling between the two emissive centers does not exist. Therefore, by selectively exciting these hybrid films with different wavelengths, the luminescence colors of them can be tuned from blue (for ZIF‐8) to red (for Eu3+), green (for Tb3+), yellow (for Eu3+/Tb3+) and even to white by integrating the emission of both Eu3+/Tb3+ into the polymer unit (PEMA‐PVPD). These results are useful and have potential application in optical devices for displays or encoding.
Ratiometric Detection of Adenosine‐5′‐triphosphate (ATP) and Cytidine‐5′‐triphosphate (CTP) with a Fluorescent Spider‐Like Receptor in Water
Authors: Gupta Abhishek Kumar , Dhir Abhimanew , Pradeep Chullikkattil P. 
Published: November 2014

AbstractA series of water‐soluble spider‐like receptor molecules has been developed by the Schiff‐base condensation of tris(hydroxymethyl)aminomethane (TRIS) with various 2,6‐diformylphenol (dfp) derivatives. The products were assessed for their anion sensing properties. Among these, the receptor with a methoxy substituent showed selective fluorescent sensing towards adenosine‐5′‐triphosphate (ATP) and cytidine‐5′‐triphosphate (CTP) in contrasting modes in 100 % aqueous media at pH 7.2.
Distinct anatomical correlates of discriminability and criterion setting in verbal recognition memory revealed by lesion‐symptom mapping
Authors: Biesbroek J. Matthijs , van Zandvoort Martine J.E. , Kappelle L. Jaap , Schoo Linda , Kuijf Hugo J. , Velthuis Birgitta K. , Biessels Geert Jan , Postma Albert ,   On behalf of the Utrecht VCI study group
Published: November 2014

AbstractRecognition memory, that is, the ability to judge whether an item has been previously encountered in a particular context, depends on two factors: discriminability and criterion setting. Discriminability draws on memory processes while criterion setting (i.e., the application of a threshold resulting in a yes/no response) is regarded as a process of cognitive control. Discriminability and criterion setting are assumed to draw on distinct anatomical structures, but definite evidence for this assumption is lacking. We applied voxel‐based and region of interest‐based lesion‐symptom mapping to 83 patients in the acute phase of ischemic stroke to determine the anatomical correlates of discriminability and criterion setting in verbal recognition memory. Recognition memory was measured with the Rey Auditory Verbal Learning Test. Signal‐detection theory was used to calculate measures for discriminability and criterion setting. Lesion‐symptom mapping revealed that discriminability draws on left medial temporal and temporo‐occipital structures, both thalami and the right hippocampus, while criterion setting draws on the right inferior frontal gyrus. Lesions in the right inferior frontal gyrus were associated with liberal response bias. These findings indicate that discriminability and criterion setting indeed depend on distinct anatomical structures and provide new insights in the anatomical correlates of these cognitive processes that underlie verbal recognition memory. Hum Brain Mapp 36:1292–1303, 2015. © 2014 Wiley Periodicals, Inc.
CA‐074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c‐FOS signaling pathways
Authors: Patel Neel , Nizami Saqib , Song Lee , Mikami Maya , Hsu Anny , Hickernell Thomas , Chandhanayingyong Chandhanarat , Rho Shim , Compton Jocelyn T. , Caldwell Jon‐Michael , Kaiser Philip B. , Bai Hanying , Lee Heon Goo , Fischer Charla R. , Lee Francis Y. 
Published: November 2014

ABSTRACTThe osteoclast is an integral cell of bone resorption. Since osteolytic disorders hinge on the function and dysfunction of the osteoclast, understanding osteoclast biology is fundamental to designing new therapies that curb osteolytic disorders. The identification and study of lysosomal proteases, such as cathepsins, have shed light on mechanisms of bone resorption. For example, Cathepsin K has already been identified as a collagen degradation protease produced by mature osteoclasts with high activity in the acidic osteoclast resorption pits. Delving into the mechanisms of cathepsins and other osteoclast related compounds provides new targets to explore in osteoclast biology. Through our anti‐osteoclastogenic compound screening experiments we encountered a modified version of the Cathepsin B inhibitor CA‐074: the cell membrane‐permeable CA‐074Me (L‐3‐trans‐(Propylcarbamoyl) oxirane‐2‐carbonyl]‐L‐isoleucyl‐L‐proline Methyl Ester). Here we confirm that CA‐074Me inhibits osteoclastogenesis in vivo and in vitro in a dose‐dependent manner. However, Cathepsin B knockout mice exhibited unaltered osteoclastogenesis, suggesting a more complicated mechanism of action than Cathepsin B inhibition. We found that CA‐074Me exerts its osteoclastogenic effect within 24 h of osteoclastogenesis stimulation by suppression of c‐FOS and NFATc1 pathways. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1474–1486, 2015.
Characterization of starter kimchi fermented with Leuconostoc kimchiiGJ2 and its cholesterol‐lowering effects in rats fed a high‐fat and high‐cholesterol diet
Authors: Jo Se Yeon , Choi Eun A , Lee Jae Joon , Chang Hae Choon 
Published: November 2014

AbstractBACKGROUNDThe hypocholesterolemic effects of lactic acid bacteria and kimchi have been demonstrated previously. However, the kimchi fermentation process still relies on naturally present microorganisms. To obtain functional kimchi with consistent quality, we validated the capacity of Leuconostoc kimchii GJ2 as a starter culture to control kimchi fermentation. Moreover, cholesterol‐lowering effects of starter kimchi as a health‐promoting product were explored.RESULTSBacteriocin production by Lc. kimchii GJ2 was highly enhanced in the presence of 5% Lactobacillus sakei NJ1 cell fractions. When kimchi was fermented with bacteriocin‐enhanced Lc. kimchii GJ2, Lc. kimchii GJ2 became overwhelmingly predominant (98.3%) at the end of fermentation and maintained its dominance (up to 82%) for 84 days. Growing as well as dead cells of Lc. kimchii GJ2 showed high cholesterol assimilation (in vitro). Rats were fed a high‐fat and high‐cholesterol diet supplemented with starter kimchi. The results showed that feeding of starter kimchi significantly reduced serum total cholesterol, triglyceride and low‐density lipoprotein cholesterol levels. Additionally, atherogenic index, cardiac risk factor and triglyceride and total cholesterol levels in liver and epididymal adipose tissue decreased significantly in rats fed starter kimchi.CONCLUSIONKimchi fermented with Lc. kimchii GJ2 as a starter culture has efficient cholesterol‐lowering effects. © 2014 Society of Chemical Industry