bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAYANAN POS BANTUAN HUKUM (POSBAKUM) DI PENGADILAN AGAMA KOTA PANGKALPINANG KELAS 1A
Authors: Sobari Alwan 
Published: August 2024

The legal aid post is one of the units in the court to assist underprivileged people in obtaining information, consultation and legal advice as well as preparing legal document needed by underprivileged people. According to supreme court regulation no.1 of 2014 concerning guideline for providing legal service to underprivileged people in court, there are three scopes of providing legal service to underprivileged people, namely court case fee waiver service outside the court building and legal aid post in the general court environment, religious court, and state administrative court. Pangkalpinang religious court is the one that has implemented this service. However, from observation and research carried out by the research team, the provision of free legal aid service is considered to be less targeted because it was found that there were people who received them in the “well-off “ category, so that many people who are truly poor cannot get free legal aid. This is only because the quota is limited and has been used for previous cases. Therefore, ,according to the research team, an evaluation is needed by the Pangkalpinang religious court to really find out the real domicile of the people who apply for this legal aid post service so that it can be assessed and decided whether they are worthy or not to receive the legal aid service. So, it is hoped that the state budget for legal aid service will be truly targeted and given to underprivileged people in obtaining legal aid service.
Clinical evaluation of skin lesions among patients with systemic lupus erythematosus: Experience from a tertiary care centre
Authors: Haider Mohammad Ziaul , Islam Md. Nazrul , Asaduzzaman A.T.M. , Majumder Muhammad Shoaib Momen , Shazzad Md Nahiduzzamane , Alam Mohammad Jahangir Ul , Ferdous Nira 
Published: August 2024

Background: Lupus patients frequently exhibit specific and nonspecific skin lesions and lesions associated with skin infections. This study aimed to determine the frequency of lupus-specific and non-specific skin lesions and the incidence of skin infections.
Methods: This study was conducted in the Department of Rheumatology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from 2014 to 2016. After obtaining ethical clearance from the Institutional Review Board of BSMMU, 136 consecutive patients fulfilling the ACR criteria for SLE were enrolled and followed up for at least one year. A dermatologist confirmed lupus-specific, non-specific, and skin lesions related to infections and noted them in a datasheet. Relevant investigations were performed at baseline and during subsequent follow-up visits.
Results: One hundred thirty-one patients completed their follow-up period. The mean (standard deviation) follow-up period was 13.3 (2.0) months. The patients' mean (standard deviation) age was 28.8 (8.2) years. Skin lesions and skin infections were present in 71.8% and 26.7%, respectively of patients. Common lupus-specific lesions were malar rash (75.4%) and DLE (12.3%). Photosensitivity (72.6%), non-scarring alopecia (67.9%), mucosal ulcers (47.6%), Raynaud’s phenomenon (23.8%), and hyperpigmentation (23.8%) were the prevalent lupus non-specific skin lesions. The common skin infections were tinea (42.9%), herpes infection (34.3%), paronychia (20%), and scabies (17%).
Conclusions: Skin lesions related to infections were common, along with lupus-specific and nonspecific lesions skin lesions. Tinea and herpes infections were more common skin infections.
KANDUNGAN MINERAL SAPI BALI BUNTING DAN TIDAK BUNTING DI WILAYAH PESISIR DESA SANTAN ILIR KECAMATAN MARANGKAYU KABUPATEN KUTAI KARTANEGARA
Authors: Sukarno Rachmad , Indana Khoiru , Manullang Julinda Romauli 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui status kandungan mineral kalsium, magnesium, natrium, tembaga, dan zinc pada serum darah sapi Bali yang dipelihara di wilayah pesisir Desa Santan Ilir Kecamatan Marangkayu. Sampel berupa serum darah dari 3 ekor sapi bunting, 3 ekor sapi tidak bunting dan 3 ekor sapi dara yang dipelihara secara ekstensif. Analisa data dilakukan secara deskriptif. Hasil penelitian menunjukkan rata-rata kandungan mineral Ca sapi bunting (12,30 mg/L), sapi tidak bunting (11,51 mg/L), dan sapi dara (11,61 mg/L). Rata-rata kandungan Mg sapi bunting (13,73 mg/L), sapi tidak bunting (11,65 mg/L), dan sapi dara (10,65 mg/L). Rata-rata kandungan Na pada sapi bunting (96,08 mg/L), sapi tidak bunting (111 mg/L), dan sapi dara (98,07 mg/L). Rata-rata kandungan Cu sapi bunting (25,15 mg/L), sapi tidak bunting (13,02 mg/L), dan sapi dara (6,10 mg/L). Rata-rata kandungan Zn sapi bunting (29,65 mg/L), sapi tidak bunting (27,72 mg/L), dan sapi dara (32,72 mg/L). dari hasil tersebut dapat disimpulkan bahwa mineral Ca, Mg, Na, Cu, dan Zn pada sapi bunting, tidak bunting, dan dara yang dipelihara di wilayah pesisir memiliki hasil yang berbeda, berada pada taraf normal, dibawah normal, dan diatas normal dari standar kebutuhan mineral meter.
PERBANDINGAN ISI RUMEN SAPI DAN RUMPUT ODOT DALAM PEMBUATAN SILASE PAKAN KOMPLIT TERHADAP KANDUNGAN BAHAN KERING, BAHAN ORGANIK DAN KECERNAAN IN VITRO
Authors: Omenu Vebriana , Lazarus Edwin J.L , Lawa Emma Dyelim Wie , Hilakore Maritje Aleonor 
Published: August 2024

Penelitian ini bertujuan untuk mengevaluasi pengaruh perbandingan isi rumen sapi dan rumput odot pada pembuatan silase pakan komplit terhadap kandungan bahan kering, bahan organik dan kecernaan secara in vitro. Metode yang digunakan dalam penelitian ini adalah metode eksperimental dengan menggunakan rancangan acak lengkap (RAL) terdiri dari 4 perlakuan 4 ulangan. Perlakuan yang diterapkan adalah P0: rumput odot 70% + konsentrat 30%, P1: isi rumen sapi 10% + rumput odot 60% + konsentrat 30%, P2: isi rumen sapi 20% + rumput odot 50% + konsentrat 30%, P3: isi rumen sapi 30% + rumput odot 40% + konsentrat 30%. Variabel yang diukur adalah kandungan bahan kering, bahan organik serta kecernaan bahan kering, bahan organik. Data dianalisis menggunakan Analysis of variance (ANOVA) dan dilanjutkan dengan uji jarak berganda Duncan. Hasil analisis statistik menunjukkan perlakuan berpengaruh sangat nyata (P<0,01) terhadap kandungan bahan kering dan bahan organik serta kecernaan bahan kering dan bahan organik. Disimpulkan bahwa semakin tinggi level isi rumen sapi dan menurunnya level rumput odot dalam silase pakan komplit meningkatkan kandungan bahan kering, namun kandungan bahan organik dan kecernaan in vitro menurun.
Single center experience with more than 600 drug desensitization in Colombia
Authors: Pardo-Manrique Verónica , Ramírez-Zuluaga Luis Fernando , Silva-Espinosa Diana Lucia , Hurtado-Bermudez Leidy Johanna , Gómez-Hernández Inés Elvira , Olaya-Hernández Manuela , Serrano-Reyes Carlos Daniel 
Published: August 2024

BackgroundDrug hypersensitivity reactions (DHRs) have a significant impact on both, patient and their treating physicians; it is considered a public health concern. The history of allergy to drugs, limits therapeutic options and will lead to the use of more expensive and potentially less effective options. Drug desensitization (DD) is considered as a procedure with a positive impact on the prognosis of the patient's disease. The objective of this study is to describe the experience with a substantial number of drugs desensitization in a fourth level center in Cali, Colombia.MethodsAn observational, cross-sectional and descriptive study was conducted. Patients with DHRs who underwent a standardized institutional DD protocol, between March of 2012 and May of 2023, were included.ResultsTwo hundred forty-one patients were included. The median age was 47.8 years (4–88). One hundred fifty-six (64.7%) were women, including three who were pregnant. A total of 641 DDs were performed. The most frequent groups of drugs for which the desensitization was performed were monoclonal antibodies in 83 patients (34.4%), chemotherapeutic agents in 53 (21.6%), NSAIDs in 44 (18.2%), and antibiotics in 42 (17.4%). Eighty-seven patients (36.1%) experienced hypersensitivity to the culprit drug on first exposure, while 154 (63.9%) exhibited reactions during subsequent cycles. The main clinical presentation that gave rise to desensitization was anaphylaxis in 125 patients (51.8%), followed by cutaneous symptoms in 106 patients (44%). The predominant observed endophenotype was type 1 in 188 patients (78.3%), followed by mixed type in 46 patients (19.2%). Breakthrough reactions were observed in 50 patients (20.7%). Tolerance to DD was achieved in 636 of the procedures (99.2%), allowing the continuity of treatment of choice for the underlying disease.ConclusionsMost desensitized patients were women with type I reactions. Monoclonal antibodies were the most frequent culprit drugs. DD in patients with DHRs is a useful, safe and effective procedure. The administration of the implicated drug had a positive impact on the course of the disease in these patients.
Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study
Authors: Li Yang , Miao Yahu , Feng Qing , Zhu Weixi , Chen Yijing , Kang Qingqing , Wang Zhen , Lu Fangting , Zhang Qiu 
Published: August 2024

BackgroundMitochondrial dysfunction plays a crucial role in Type 2 Diabetes Mellitus (T2DM) and its complications. However, the genetic pathophysiology remains under investigation. Through multi-omics Mendelian Randomization (MR) and colocalization analyses, we identified mitochondrial-related genes causally linked with T2DM and its complications.MethodsSummary-level quantitative trait loci data at methylation, RNA, and protein levels were retrieved from European cohort studies. GWAS summary statistics for T2DM and its complications were collected from the DIAGRAM and FinnGen consortiums, respectively. Summary-data-based MR was utilized to estimate the causal effects. The heterogeneity in dependent instrument test assessed horizontal pleiotropy, while colocalization analysis determined whether genes and diseases share the same causal variant. Enrichment analysis, drug target analysis, and phenome-wide MR were conducted to further explore the biological functions, potential drugs, and causal associations with other diseases.ResultsIntegrating evidence from multi-omics, we identified 18 causal mitochondrial-related genes. Enrichment analysis revealed they were not only related to nutrient metabolisms but also to the processes like mitophagy, autophagy, and apoptosis. Among these genes, Tu translation elongation factor mitochondrial (TUFM), 3-hydroxyisobutyryl-CoA hydrolase (HIBCH), and iron-sulfur cluster assembly 2 (ISCA2) were identified as Tier 1 genes, showing causal links with T2DM and strong colocalization evidence. TUFM and ISCA2 were causally associated with an increased risk of T2DM, while HIBCH showed an inverse causal relationship. The causal associations and colocalization effects for TUFM and HIBCH were validated in specific tissues. TUFM was also found to be a risk factor for microvascular complications in T2DM patients including retinopathy, nephropathy, and neuropathy. Furthermore, drug target analysis and phenome-wide MR underscored their significance as potential therapeutic targets.ConclusionsThis study identified 18 mitochondrial-related genes causally associated with T2DM at multi-omics levels, enhancing the understanding of mitochondrial dysfunction in T2DM and its complications. TUFM, HIBCH, and ISCA2 emerge as potential therapeutic targets for T2DM and its complications.
Incidence and risk factors for amputation in Chinese patients with diabetic foot ulcers: a systematic review and meta-analysis
Authors: Zhang Yujie , Liu Hui , Yang Yadi , Feng Chaochen , Cui Liwei 
Published: August 2024

ObjectiveThis study aimed to comprehensively analyze the incidence of amputation in Chinese patients with diabetic foot ulcers (DFUs).MethodsThe Preferred Reporting Items for a Systematic Review and Meta-analysis (PRISMA) guidelines were used. The CNKI, Wanfang Data, VIP, PubMed, Web of Science, and Embase databases were searched to collect relevant literature on the incidence of amputation in Chinese patients with DFUs. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias. The data were systematically analyzed using Stata 17.0 software to determine the incidence of amputation in this patient population.ResultsA total of 25 papers were included in the study, revealing an incidence of amputation in Chinese patients with DFUs of 22.4% (95% confidence interval: 18.3–26.5%). The subgroup analysis revealed that a history of ulcers, Wagner grade &gt;3, and diabetic peripheral vascular disease were the primary risk factors associated with a higher incidence of amputation in Chinese patients with DFUs (P&lt;0.05). Among Chinese patients with DFUs, the amputation group and the non-amputation group showed significant differences in body mass index, duration of DFUs, total cholesterol, triglyceride, fasting blood glucose, white blood cell count, hemoglobin A1c, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and uric acid (P&lt;0.05).ConclusionThe high incidence of amputation among Chinese patients with DFUs indicates that interventions should be implemented to prevent or minimize amputations.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42023463976.
Effects of canagliflozin on kidney oxygenation evaluated using blood oxygenation level-dependent MRI in patients with type 2 diabetes
Authors: Mori Katsuhito , Inoue Tsutomu , Machiba Yuri , Uedono Hideki , Nakatani Shinya , Ishikawa Masahiro , Taniuchi Satsuki , Katayama Yutaka , Yamamoto Akira , Kobayashi Naoki , Kozawa Eito , Shimono Taro , Miki Yukio , Okada Hirokazu , Emoto Masanori 
Published: August 2024

BackgroundRecent clinical studies suggest protective effects of SGLT2 inhibitors on kidney disease outcome. Chronic hypoxia has a critical role in kidney disease development, thus we speculated that canagliflozin, an SGLT2 inhibitor, can improve kidney oxygenation.MethodsA single-arm study was conducted to investigate the effects of canagliflozin on T2* value, which reflects oxygenation level, in patients with type 2 diabetes (T2D) using repeated blood oxygenation level-dependent MRI (BOLD MRI) examinations. Changes in cortical T2* from before (Day 0) to after single-dose treatment (Day 1) and after five consecutive treatments (Day 5) were evaluated using 12-layer concentric objects (TLCO) and region of interest (ROI) methods.ResultsIn the full analysis set (n=14 patients), the TLCO method showed no change of T2* with canagliflozin treatment, whereas the ROI method found that cortical T2* was significantly increased on Day 1 but not on Day 5. Sensitivity analysis using TLCO in 13 well-measured patients showed that canagliflozin significantly increased T2* on Day 1 with no change on Day 5, whereas a significant improvement in cortical T2* following canagliflozin treatment was found on both Day 1 and 5 using ROI.ConclusionsShort-term canagliflozin treatment may improve cortical oxygenation and lead to better kidney outcomes in patients with T2D.
Mucosal immunity in upper and lower respiratory tract to MERS-CoV
Authors: Shrwani Khalid J. , Mahallawi Waleed H. , Mohana Abdulrhman I. , Algaissi Abdullah , Dhayhi Nabil , Sharwani Nouf J. , Gadour Eyad , Aldossari Saeed M. , Asiri Hasan , Kameli Nader , Asiri Ayad Y. , Asiri Abdullah M. , Sherwani Alaa J. , Cunliffe Nigel , Zhang Qibo 
Published: August 2024

IntroductionMiddle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a deadly pathogen with a mortality rate of up to 36.2%. MERS-CoV can cause severe respiratory tract disease and multiorgan failure. Therefore, therapeutic vaccines are urgently needed. This intensive review explores the human immune responses and their immunological mechanisms during MERS-CoV infection in the mucosa of the upper and lower respiratory tracts (URT and LRT, respectively).ObjectiveThe aim of this study is to provide a valuable, informative, and critical summary of the protective immune mechanisms against MERS-CoV infection in the URT/LRT for the purpose of preventing and controlling MERS-CoV disease and designing effective therapeutic vaccines.MethodsIn this review, we focus on the immune potential of the respiratory tract following MERS-CoV infection. We searched PubMed, Embase, Web of Science, Cochrane, Scopus, and Google Scholar using the following terms: “MERS-CoV”, “B cells”, “T cells”, “cytokines”, “chemokines”, “cytotoxic”, and “upper and lower respiratory tracts”.ResultsWe found and included 152 studies in this review. We report that the cellular innate immune response, including macrophages, dendritic cells, and natural killer cells, produces antiviral substances such as interferons and interleukins to prevent the virus from spreading. In the adaptive and humoral immune responses, CD4+ helper T cells, CD8+ cytotoxic T cells, B cells, and plasma cells protect against MERS-CoV infection in URT and LRT.ConclusionThe human nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT) could successfully limit the spread of several respiratory pathogens. However, in the case of MERS-CoV infection, limited research has been conducted in humans with regard to immunopathogenesis and mucosal immune responses due to the lack of relevant tissues. A better understanding of the immune mechanisms of the URT and LRT is vital for the design and development of effective MERS-CoV vaccines.
Translation and cultural adaptation of the COVID-19 Yorkshire Rehabilitation Scale into German
Authors: Sperl Lisa , Stamm Tanja , Mosor Erika , Ritschl Valentin , Sivan Manoj , Hoffmann Kathryn , Gantschnig Brigitte 
Published: August 2024

BackgroundExperts estimate that in up to 10% of the infected, SARS-CoV-2 would cause persistent symptoms, activity limitations and reduced quality of life. Referred to as long COVID, these conditions might, in the future, specifically impact German-speaking countries due to their higher rates of unvaccinated people compared to other Western countries. Accurate measurement of symptom burden and its consequences is needed to manage conditions such as long COVID, and several tools have been developed to do so. However, no patient-reported instrument existed in the German language at the time of writing.ObjectiveThis study, therefore, aimed to develop a German version of the COVID-19 Yorkshire Rehabilitation Scale (C19-YRS).MethodsWe conducted a translation and qualitative evaluation, including cultural adaptation, of the C19-YRS and assessed its face validity. After creating a preliminary version, 26 individuals (14 women [53%]) participated in cognitive interviews (January 2022 to March 2022). Using cognitive debriefing interviews, we ensured the content’s comprehensibility. The matrix-framework method guided the qualitative data analysis.ResultsCompared to the original English version, adaptations were necessary, resulting in changes to the introductory text, while the items for recording persistent symptoms were hardly changed.ConclusionThe German version of the C19-YRS is expected to support standardized long COVID care.
Next move in movement disorders: neuroimaging protocols for hyperkinetic movement disorders
Authors: Dalenberg Jelle R. , Peretti Debora E. , Marapin Lenny R. , van der Stouwe A. M. Madelein , Renken Remco J. , Tijssen Marina A. J. 
Published: August 2024

IntroductionThe Next Move in Movement Disorders (NEMO) study is an initiative aimed at advancing our understanding and the classification of hyperkinetic movement disorders, including tremor, myoclonus, dystonia, and myoclonus-dystonia. The study has two main objectives: (a) to develop a computer-aided tool for precise and consistent classification of these movement disorder phenotypes, and (b) to deepen our understanding of brain pathophysiology through advanced neuroimaging techniques. This protocol review details the neuroimaging data acquisition and preprocessing procedures employed by the NEMO team to achieve these goals.Methods and analysisTo meet the study’s objectives, NEMO utilizes multiple imaging techniques, including T1-weighted structural MRI, resting-state fMRI, motor task fMRI, and 18F-FDG PET scans. We will outline our efforts over the past 4 years to enhance the quality of our collected data, and address challenges such as head movements during image acquisition, choosing acquisition parameters and constructing data preprocessing pipelines. This study is the first to employ these neuroimaging modalities in a standardized approach contributing to more uniformity in the analyses of future studies comparing these patient groups. The data collected will contribute to the development of a machine learning-based classification tool and improve our understanding of disorder-specific neurobiological factors.Ethics and disseminationEthical approval has been obtained from the relevant local ethics committee. The NEMO study is designed to pioneer the application of machine learning of movement disorders. We expect to publish articles in multiple related fields of research and patients will be informed of important results via patient associations and press releases.
Acute generalized exanthematous pustulosis induced by icotinib: a case report and literature review
Authors: Yang Wei , Zhao Jiayu , Niu Jun 
Published: August 2024

Acute generalized exanthematous pustulosis, an infrequent adverse drug reaction, mainly results from drugs. Clinically, acute generalized exanthematous pustulosis manifests as a high fever, with skin lesions of small monomorphic subcorneal sterile pustules on an erythematous that presents at 1–4 days after medication exposure. The incidence of acute generalized exanthematous pustulosis varies from 3/1, 000, 000 to 5/1, 000, 000, while the mortality rate is typically around 5%. We present a case of a 69-year-old female who developed a diffuse, erythematous, pustular rash over the entire body and exhibited a fever of 38.3°C after 4 days of icotinib therapy. Considering her medication history and the appearance of the lesions, she was diagnosed with acute generalized exanthematous pustulosis and received appropriate treatment. We also conducted a literature review through PubMed to compare similarities and differences between our case and those reported in the literature.