bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sieving‐type Electric Double Layer with Hydrogen Bond Interlocking to Stable Zinc Metal Anode
Authors: Yan Tong , Wu Boyong , Liu Sucheng , Tao Mengli , Liang Jinhui , Li Minjian , Xiang Cong , Cui Zhiming , Du Li , Liang Zhenxing , Song Huiyu 
Published: August 2024

AbstractThe stability of aqueous zinc metal batteries is significantly affected by side reactions and dendrite growth on the anode interface, which primarily originate from water and anions. Herein, we introduce a multi H‐bond site additive, 2, 2′‐Sulfonyldiethanol (SDE), into an aqueous electrolyte to construct a sieving‐type electric double layer (EDL) by hydrogen bond interlock in order to address these issues. On the one hand, SDE replaces H2O and SO42− anions that are adsorbed on the zinc anode surface, expelling H2O/SO42− from the EDL and thereby reducing the content of H2O/SO42− at the interface. On the other hand, when Zn2+ are de‐solvated at the interface during the plating, the strong hydrogen bond interaction between SDE and H2O/SO42− can trap H2O/SO42− from the EDL, further decreasing their content at the interface. This effectively sieves them out of the zinc anode interface and inhibits the side reactions. Moreover, the unique characteristics of trapped SO42− anions can restrict their diffusion, thereby enhancing the transference number of Zn2+ and promoting dendrite‐free deposition and growth of Zn. Consequently, utilizing an SDE/ZnSO4 electrolyte enables excellent cycling stability in Zn//Zn symmetrical cells and Zn//MnO2 full cells with lifespans exceeding 3500 h and 2500 cycles respectively.
Nickel Catalyzed Carbonylative Cross Coupling for Direct Access to Isotopically Labeled Alkyl Aryl Ketones
Authors: Mühlfenzl Kim S. , Enemærke Vitus J. , Gahlawat Sahil , Golbækdal Peter I. , Munksgaard‐Ottosen Nikoline , Neumann Karoline T. , Hopmann Kathrin H. , Norrby Per‐Ola , Elmore Charles S. , Skrydstrup Troels 
Published: August 2024

AbstractHere we present an effective nickel‐catalyzed carbonylative cross‐coupling for direct access to alkyl aryl ketones from readily accessible redox‐activated tetrachlorophthalimide esters and aryl boronic acids. The methodology, which is run employing only 2.5 equivalents of CO and simple Ni(II) salts as the metal source, exhibits a broad substrate scope under mild conditions. Furthermore, this carbonylation chemistry provides an easy switch between isotopologues for stable (13CO) and radioactive (14CO) isotope labeling, allowing its adaptation to the late‐stage isotope labeling of pharmaceutically relevant compounds. Based on DFT calculations as well as experimental evidence, a catalytic cycle is proposed involving a carbon‐centered radical formed via nickel(I)‐induced outer‐sphere decarboxylative fragmentation of the redox‐active ester.
Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment
Authors: Zhen Wenyao , Germanas Tomas , Weichselbaum Ralph R. , Lin Wenbin 
Published: August 2024

AbstractCholesterol is an essential membrane component, and the metabolites from cholesterol play important biological functions to intricately support cancer progression and dampen immune responses. Preclinical and clinical studies have demonstrated the role of cholesterol metabolism regulation on inhibiting tumor growth, remodeling the immunosuppressive tumor microenvironment (TME), and enhancing anti‐tumor immunity. In this minireview, we discuss complex cholesterol metabolism in tumors, its important role in cancer progression, and its influences on immune cells in the TME. We provide an overview of recent advances in cancer treatment through regulating cholesterol metabolism. We discuss the design of cholesterol‐altering multifunctional nanomaterials to regulate oxidative stress, modulate immune checkpoints, manipulate mechanical stress responses, and alter cholesterol metabolic pathways. Additionally, we examine the interactions between cholesterol metabolism regulation and established cancer treatments with the aim of identifying efficient strategies to disrupt cholesterol metabolism and synergistic combination therapies for effective cancer treatment.
Surface Tension Manipulation with Visible Light through Sensitized Disequilibration of Photoswitchable Amphiphiles
Authors: Gemen Julius , Stövesand Bastian , Glorius Frank , Ravoo Bart Jan 
Published: August 2024

AbstractAzoarene isomerization lies at the heart of numerous applications, from catalysis or energy storage to photopharmacology. While efficient switching between their E and Z isomers predominantly relies on UV light, a recent study by Klajn and co‐workers introduced visible light sensitization of E azoarenes and their subsequent isomerization as a tool coined disequilibration by sensitization under confinement (DESC) to obtain high yields of the Z isomer. This host–guest approach is, however, still constrained to minimally substituted azoarenes with limited applicability in advanced molecular systems. Herein, we expand DESC for the assembly of surfactants at the air–water interface. Leveraging our expertise with photoswitchable amphiphiles, we induce substantial alterations of the water surface tension through reversible arylazopyrazole isomerization. After studying the binding of charged surfactants to the host, we find that the surface activity differences upon visible light switching for both isomers are comparable to those obtained by UV light excitation. The method is demonstrated on a large concentration range and can be activated using green or red light, depending on the sensitizer chosen. The straightforward implementation of photoswitch sensitization in a complex molecular network showcases how DESC enables the improvement of existing systems and the development of novel applications driven by visible light.
Synergistic effect of covalent cross‐linking and physical hydrogen bonding associations on the mechanical properties of polyurethane thermoset elastomers
Authors: Zhou Yu , Wu Fang , Zhu Liyang , Geng Zhishuai , Yang Rongjie , Zhai Jinxian 
Published: August 2024

AbstractThermoset materials, known for their stable topology structure, have garnered significant interest in recent years for their applications in coatings, foam, adhesives, and other fields. In general, the low chemical crosslinking density of thermoset materials means poor mechanical properties. In this study, we adjusted the topological structure of thermoset elastomers through formula design and controlled their hard segment content at the same level. The mechanical tensile test results show that as the chemical crosslinking density of the elastomer decreases, the fracture tensile strength shows a trend of first increasing and then decreasing. Although the content of amino ester groups in the elastomer is the same, low field nuclear magnetic resonance and Fourier transform infrared analysis show that as the density of the chemical cross‐linking network decreases, more physical cross‐linking points are formed between the elastomer network chains. Furthermore, the polyurethane hard segment formed an amorphous microphase separation structure in the elastic matrix. This study proves that constructing a moderate physical hydrogen bonding association structure between the network chains in polyurethane cross‐linked thermoset elastomers is another important way to prepare thermoset elastomers with excellent mechanical properties.
Mechanism of improving the mechanical and barrier properties of poly(lactide)/poly(butylene adipate‐co‐terephthalate) blends
Authors: Xie Yongjian , Wang Chenxi , Gao Shang , Li Zhen , Cheng Sheng , Yin Haoyan , Zhou Yiyang , Ding Yunsheng 
Published: August 2024

AbstractPoly(lactide)/poly(butylene adipate‐co‐terephthalate) (PLA/PBAT) blends containing different amounts of polyethylene wax (PEW) were fabricated via melt‐blending, and the effects of PEW on the interfacial morphological evolution and properties of the PLA/PBAT blends were investigated. Scanning electron microscopy (SEM) micrographs show that the compatibility between PLA and PBAT is obviously improved by addition of low contents of PEW. Differential scanning calorimeter (DSC) results indicate that PEW can simultaneously enhance the crystallization ability of PLA and PBAT. Rheological behavior of the blends indicates that PEW has a significant plasticizing effect and can promote the mobility of polymer chains in the blends. More importantly, it is revealed that PEW can effectively improve the mechanical and barrier properties of the blends. Even with a PEW content of only 1 wt%, the elongation at break and notched impact strength of the blend reach 344.1% and 12.55 kJ/m2, respectively, which are 54% and 140% higher than the blend without PEW. Meanwhile, the water vapor transmission rate (WVTR) and oxygen transmission rate (OTR) of the films containing 1 wt% PEW are decreased from 87.34 to 67.40 g m−2·24 h−1 and from 118.26 to 80.94 cm3 m−2·24 h−1, respectively, which are 22.8% and 31.5% lower than those of the PLA/PBAT film.
Facile fabrication of carbon nanotubes/zinc oxide decorated poly(vinyl alcohol) electrospun nanofiber membrane and its photocatalytic performance
Authors: Tan Changbin , Luo Xuan , He Haiqing , He Shan , Ren Ruiyang , Xiao Yang , Fu Yuanyuan , Huang Shihong , Cai Yongjiang , Yang Yan 
Published: August 2024

AbstractThe carbon nanotubes/zinc oxide (CNTs/ZnO) nanocomposites were immobilized on the poly(vinyl alcohol) (PVA) membrane for highly reutilization rate in photocatalytic degradation of RhodamineB (RhB) based on the combination of electrospinning and ultrasonication treatment. The results revealed that the CNTs are successfully compounded with ZnO, and the surface of nanofibers was uniformly covered with CNTs/ZnO nanoparticles. Under visible light irradiation, the CNTs/ZnO@PVA nanocomposites displayed excellent photocatalytic activity with 98.4% of RhB degradation rate within 3 h illumination. In comparison with pure PVA, and CNTs/ZnO with equivalent loading capacity on CNTs/ZnO@PVA film suspended in aqueous solution, the synthesized CNTs/ZnO@PVA film degrades RhB dye more efficiently. Furthermore, the photocatalytic activity of CNTs/ZnO@PVA nanocomposites did not change significantly even after five recycles, indicating a certain degree of reusability. The mechanism of enhanced photocatalytic activity was proposed. The as‐prepared flexible CNTs/ZnO@PVA nanocomposites could be employed as a promising material for the practical photocatalytic degradation of wastewater.
Research insight into the change of aggregation structure of BOPP films and its influence on electrical properties under accelerated thermal aging
Authors: Zhang Yunxiao , Zhang Jiarui , Liu Yuhao , Lin Wenxin , Chi Zhengnan , Zhang Tianfeng , Teng Chenyuan 
Published: August 2024

AbstractBiaxially oriented polypropylene (BOPP) film used in pulse film capacitors withstands high temperatures for a long time. This leads to frequent faults in pulse film capacitors, affecting the reliability of the pulse system. In this paper, the thermal aging tests of BOPP films at 100°C for 10–80 days are carried out in this paper, and the physicochemical and electrical properties of the aging materials are characterized. The results show that more deep and shallow traps to BOPP films are introduced during the thermal aging process. With the increase in aging time, the breakdown field strength gradually decreases, and the conductivity decreases first and then increases. Under the action of thermal aging for a long time, the recrystallization of materials and the destruction of molecular chains by thermal aging are the main reasons for the increase of traps and the decrease of breakdown field strength. The former is dominant in the early stage of aging, and the latter is dominant in the late stage of aging. Therefore, the conductivity shows the law of slow decrease first and then rapid increase. The relevant research provides a theoretical foundation for the process improvement and life prediction of BOPP films.
Targeted Prostate Health Checks, a novel system to identify men with prostate cancer—A pilot study
Authors: Langley Stephen , Goad Jeremy , Bell Stephanie , Foster Lee , Hodges Catherine , Laniado Marc , Pietrasik Michele , Rooke Alison , Knight Matthew , Bosonnet Edward , Bott Simon 
Published: August 2024

AbstractObjectivesThe objective of this study is to report the pilot phase of the Targeted Prostate Health Check programme that aims to identify men in the Surrey and Sussex region who have prostate cancer and who failed to be detected during the Covid era.Subjects and methodsMen aged 50 to 70, or 45 to 70 if Black or with a family history of prostate cancer, were identified from participating general practitioner (GP) records. Short message service (SMS) texts invited men to visit www.talkprostate.co.uk for information on prostate cancer and give consent to prostate‐specific antigen (PSA) checks coordinated by a third‐party virtual healthcare provider. Elevated age‐related PSA levels, or levels below age‐related thresholds but at 3 ng/mL or more, triggered referral to a rapid access urology clinic. GPs were informed of the results.ResultsFrom 1842 text messages inviting 1549 people, 544 men consented to a PSA check. From 500 phlebotomy appointments, 485 (30% of invited men) took the PSA test of whom 68 (14%) were referred with an elevated PSA. After clinical review with multiparametric magnetic resonance imaging (mp‐MRI), 22 patients underwent transperineal biopsies, and prostate cancer was detected in 18 men of whom 17 (95%) had clinically significant cancer.ConclusionOur Targeted Prostate Cancer Health Check system identifies men at risk without burdening primary care. Awareness on prostate cancer risk was raised in 1549 invited men, half of whom were further educated via the registration website. One third of invited men were checked in whom clinically significant prostate cancer was found in 3.5%.
A Repurposing Pipeline to Candidate‐Suitable Inhibitors of Tyrosinase: Computational and Bioassay Studies
Authors: Kabiri Maryam , Hajizade Mohammad Soroosh , Zarei Mina , Eskandari Simin , Sakhteman Amirhossein , Khoshneviszadeh Mehdi 
Published: August 2024

AbstractTyrosinase, a metalloprotein enzyme, plays a crucial role in melanin synthesis by hydroxylating L‐tyrosine to L‐dopa. However, the accumulation of melanin can lead to hyperpigmented spots, raising aesthetic concerns. In this study, we developed a pipeline to repurpose FDA‐approved drugs as potential tyrosinase inhibitors. A structure‐based screening study was conducted using 1,650 drugs to identify probable inhibitors based on binding energies. From the cluster analysis of binding interaction profiles, 16 compounds were selected as candidates. Montelukast emerged as the final candidate due to its favorable ADME properties. Bioassay evaluation revealed an IC50 value of 14.79±0.87 μM for Montelukast, compared to kojic acid (IC50=31.02±2.01 μM). Molecular dynamics simulation and g_MMPBSA free energy calculation studies were performed for the Tyrosinase‐Montelukast complex. These findings enhance our understanding of Tyrosinase‐Montelukast interactions and underscore Montelukast's potential as a tyrosinase inhibitor. This could have implications in dermatological applications and beyond, suggesting Montelukast as a promising candidate for further development in this regard.
Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential
Authors: Sobhy Marina , AbouZid Sameh F. , Kirollos Farid N. , El‐Shiekh Riham A. , Abdel‐Sattar Essam 
Published: August 2024

AbstractThere is an increasing interest in using iridoids and secoiridoids as major targets for chemical synthesis and biosynthesis. Iridoids can be found in numerous species of Lamiaceae, Verbenaceae, Scrophulariaceae, and other families. Iridoids possess a chemical structure characterized by a cyclopentane ring with oxidative substituents, forming a six‐membered ring. Various research groups have used these structures as valuable starting materials for regioselective and stereoselective synthesis. This approach has enormous potential for the production of bioactive alkaloids, prostaglandin analogues, and other bioactive natural compounds. Because there is currently no review on lamiide and ipolamiide, this review intends to pique researchers’ interest in this vital topic of natural science for drug discovery from naturally occurring iridoids. Lamiide and ipolamiide have the potential to be useful tools in the pharmaceutical sector, enabling the use of these plant metabolites in a variety of medicinal compositions. Given that these molecules appear to be potential natural substances for treating human ailments, we get light on them as alternative therapeutic approaches using these compounds alone or in combination with other substances which will potentially lead to future (pre)‐clinical investigations.
Heteroaryl Group Containing Trisubstituted Alkenes: Synthesis and Anti‐Tumor Activity
Authors: Li Jiatong , Gu Ao , Li Meng‐Yao 
Published: August 2024

AbstractPancreatobililary cancers are fatal solid tumors that pose a significant threat to human life. It is imperative to investigate novel small molecule active compounds for controlling these cancers. Heterocyclic compounds (e. g. gemcitabine) and multi‐substituted alkenes (e. g. resveratrol) are commonly applied in tumor treatment. Researchers have proposed that the synthesis of new trisubstituted alkenes containing heteroaromatic rings by combining these two scaffolds may be a fresh strategy to develop new active molecules. In this study, we utilized alkenyl bromide and heteroaryl boronic acid as substrates, employing Suzuki coupling to generate a series of triarylethylenes featuring nitrogen, oxygen, and sulfur atoms. Through in vitro experiments, the results indicated that some compounds exhibited remarkable anti‐tumor efficacy (e. g. IC50[3be, GBC‐SD]=0.13 μM and IC50[3be, PANC‐1]=0.27 μM). The results further demonstrated that the antitumor efficacy of these compounds was dependent on the heteroatom, π‐system, skeleton‐bonding site, and substituent type.
Biotransformation of Glaucic Acid Isolated from the Root of Lindera glauca by the Endophytic Fungi Penicillium Chrysogenum SHJ‐07
Authors: Zou Qinghui , Wei Jinqin , Chen Zelin , Luo Anni , He Jingxin , Long Yongling , Cui Hui , Liu Yena 
Published: August 2024

AbstractGlaucic acid isolated from the root of Lindera glauca, was investigated by the biotransformation methods via the endophytic fungi, resulting in the production of five new glausesquiterpenes A–E (1–5), along with a known analogue 6. Their structures were elucidated based on spectroscopic methods and electronic circular dichroism (ECD) calculations. In the bioassays, glausesquiterpene A (1) showed good inhibitory activity of NO production in LPS‐activated RAW 264.7 macrophages with an IC50 value of 20.1 μM than positive control (Indomethacin, IC50 24.1 μM). Further in vitro studies demonstrated that glausesquiterpene A significantly suppressed the protein expression of iNOS and COX‐2 at the concentration of 25.0 μM.
Adsorption and Distribution of Triplex‐Hybridizing Bioconjugated Gold Nanoclusters Inside Spermatozoa‐ A Study Using Confocal Microscopy and Fluorescence Lifetime Imaging
Authors: Gamrad‐Streubel Lisa , Kundu Sangita , Streich Carmen , Ramesh Vaijayanthi , Schielke Andreas , Rehbock Christoph , Cordes‐Blauert Merle , Franzka Steffen , Klein Sabine , Kues Wilfried A. , Rath Detlef , Barcikowski Stephan 
Published: August 2024

AbstractThe study of the interactions between biofunctionalized gold nanoclusters (Au NCs) and spermatozoa is highly relevant to evaluate the potential of Au NCs as imaging probes and transfection agents in reproductive biology. In this work, confocal laser scanning microscopy (CLSM) was used to investigate the distribution of Au NCs bioconjugated with peptide (nuclear localisation sequence, NLS) and oligonucleotide (locked nucleic acid, LNA) ligands in bovine spermatozoa. Fluorescence lifetime imaging (FLIM) was employed to detect changes in the NC's chemical environment. We observed a pronounced regio‐selective accumulation of the bioconjugates in spermatozoa with high concentration at the equatorial segment. Furthermore, 3D‐CLSM showed successful non‐endosomal cellular uptake of the conjugates by intact sperm cells and the distribution of the bioconjugates was found to be influenced by the ligand types. Interestingly, the FLIM data showed differences in lifetime depending on membrane integrity. Furthermore, ligand‐dependent changes in lifetime between NC bioconjugates carrying peptide and oligonucleotide ligands were found, probably attributed to specific interactions with sperm cell compartments.
Small cell lung cancer associated small bowel obstruction, a diagnostic conundrum: A case report
Authors: Ayoub Mohammad , AbuHaweeleh Mohannad Natheef , Mahmood Nabil , Clelland Colin , Ayoub Malak Mohammad , Saman Harman 
Published: August 2024

Key clinical messageSmall cell lung cancer (SCLC), a neuroendocrine aggressive subtype of lung cancer, is associated with paraneoplastic disorders in about 9% of patients. In this report, we describe a middle‐aged man who presented with chronic bowel obstruction caused by chronic intestinal pseudo‐obstruction (CIPO) due to SCLC.
Study on the Scale and Corrosion Inhibition Effect of Curcumin‐Based Novel Polymers
Authors: Qi Jinwei , Li Jihui , Liu Kaili , Zhang Huixin , Han Jian , Chen Jianxin 
Published: August 2024

AbstractThe curcumin‐malic acid‐aspartic acid polymer (PCMA) as a new water treatment agent was prepared by solid phase synthesis of curcumin, malic acid and aspartic acid. The static scale inhibition experiments showed that PCMA can inhibit CaCO3 and CaSO4 scale formation by 100.0 % and had excellent scale inhibition effect under various experimental conditions. The mechanism of action of PCMA was obtained by X‐ray diffraction, scanning electron microscope and molecular dynamics simulation. Electrochemical test showed that PCMA is an anodic corrosion inhibitor that achieves 93.1 % corrosion inhibition by forming a protective film on the surface of Q235 carbon steel. Besides, fluorescence spectra proved that PCMA has stable fluorescence intensity.
Correlates of money attitudes among Portuguese people
Authors: Neto Joana , Neto Félix , Furnham Adrian 
Published: August 2024

AbstractThis study examined the psychometric features of the New Money Attitudes Questionnaire (NMAQ) in a Portuguese population and the relations between money attitudes, participant demographics, well‐being, and personality factors. The sample comprised 241 participants aged between 18 and 66 years. They completed the NMAQ and measures of financial well‐being, loneliness, and personality. The results of a CFA displayed a good fit for the five‐factor model of the NMAQ, and adequate reliability. Men scored significantly higher than women in Power and Status, and women scored significantly higher than men in Mindful and Responsible. The effect of age on money attitudes was not significant. Participants with lower educational levels scored significantly greater than those with higher educational level in Power and Status and Financial Literacy Worries. Well‐being and personality factors explained a significant amount of variance regarding money attitudes.