bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: High Performance of a Palladium Phosphinooxazoline Catalyst in the Asymmetric Arylation of Cyclic N‐Sulfonyl Ketimines.
Authors: Jiang Chunhui , Lu Yixin , Hayashi Tamio 
Published: February 2015

AbstractThe asymmetric addition of arylboronic acids to N‐sulfonyl ketimines is efficiently catalyzed by a chiral Pd‐oxazoline catalyst to give the corresponding arylation products in high yields and excellent enantioselectivities.
ChemInform Abstract: Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5‐Phenylsulfanyl‐ and 5‐Benzyl‐Substituted Tetrahydro‐2‐benzazepines.
Authors: Hasebein Peer , Frehland Bastian , Schepmann Dirk , Wuensch Bernhard 
Published: February 2015

AbstractA series of 5‐benzyl‐ and 5‐phenylsulfanyltetrahydrobenzazepines are synthesized and evaluated for their pharmacological activity.
ChemInform Abstract: Highly Regioselective Hydrosilylation of Unsymmetric Alkynes Using a Phenylthio Directing Group.
Authors: Huang Kuan‐Hsun , Isobe Minoru 
Published: February 2015

AbstractThe first systematic study to determine the regioselectivity for the hydrosilylation of phenylthioacetylenes in the presence of a stable cobalt carbonyl complex is reported.
ChemInform Abstract: Convenient and Chromatography‐Free Partial Syntheses of Maslinic Acid and Augustic Acid.
Authors: Sommerwerk Sven , Csuk Rene 
Published: February 2015

AbstractMaslinic acid (Ia) and augustic acid (Ib) are synthesized from the commercially available and inexpensive oleanic acid in four steps in 41% and 72% isolated yields, respectively.
ChemInform Abstract: Tricyclic and Spirobicyclic Norsesquiterpenes from the Endophytic Fungus Pseudolagarobasidium acaciicola.
Authors: Wibowo Mario , Prachyawarakorn Vilailak , Aree Thammarat , Wiyakrutta Suthep , Mahidol Chulabhorn , Ruchirawat Somsak , Kittakoop Prasat 
Published: February 2015

AbstractTogether with three known sesquiterpenes, the new tricyclic (I) and spirocyclic norsesquiterpenes (II), and the new nor‐chamigrane endoperoxide (III) are isolated from the title fungus.
ChemInform Abstract: Enantioselective Biomimetic Total Syntheses of Kuwanons I (Ia) and J (Ib) and Brosimones A (II) and B (III).
Authors: Han Jianguang , Li Xia , Guan Yong , Zhao Wenjun , Wulff William D. , Lei Xiaoguang 
Published: February 2015

AbstractThe synthesis of the title compounds is accomplished from a common intermediate.
Leistungsdatenvergleich Wärmetauscher – WTP‐Plattenkondensator versus Rohrbündel
Authors: Femmer Ulrich , Offermanns Heribert 
Published: February 2015

AbstractIm Rahmen des InnovA2‐Verbundprojektes zur Steigerung der Energieeffizienz von Produktionsprozessen wurden zwei Bauarten von Kopfkondensatoren im Hinblick auf ihre Energieeffizienz verglichen. Rohrbündel‐Wärmetauscher brauchen kostenintensive Rohrböden zur Druckabsicherung zwischen Kühlwasser und Produkt, während WTP (Wärmetauscher‐Platten‐Stystem)‐Plattenwärmetauscher druckeigensicher sind. Der Vergleich dieser beiden Systeme über Rechenmodelle ergab eine erhöhte Energieeffizienz des WTP‐Systems sowie eine erhebliche Gewichtseinsparung.
Double D–π–A Dye Linked by 2,2′‐Bipyridine Dicarboxylic Acid: Influence of para‐ and meta‐Substituted Carboxyl Anchoring Group
Authors: Ganesan Paramaguru , Chandiran Aravind Kumar , Gao Peng , Rajalingam Renganathan , Grätzel Michael , Nazeeruddin Mohammad Khaja 
Published: February 2015

AbstractStarting from 2,2′‐bipyridine dicarboxylic acid, two new (D–π–A)2 sensitizers, including m‐DA with the carboxyl anchoring group substituted meta to the donor‐bridge moiety and p‐DA with a para‐substituted anchoring group, were synthesized in order to evaluate the impact of the position of the anchoring group on the optical, electrochemical, and photovoltaic properties of dye‐sensitized solar cells. p‐DA exhibits red‐shifted absorption behavior compared to m‐DA, owing to the more efficiently extended π‐conjugation with para substitution. Both m‐DA and p‐DA are adsorbed on the mesoporous TiO2 surface by using both of their carboxylic acid groups in a bianchoring mode, which is confirmed through attenuated total reflectance FTIR analysis. Red‐shifted absorption of p‐DA assists the achievement of a red‐shifted incident photon‐to‐electron conversion efficiency and a higher short‐circuit current density than m‐DA. The photogenerated electron lifetime in TiO2 is also found to be higher for para substituted p‐DA than the meta‐substituted m‐DA, which results in a higher open‐circuit voltage. All of the results suggest that dicarboxyl‐2,2′‐bipyridine can be used as an acceptor for metal‐free organic sensitizers. However, the anchoring segments should be adjusted to the favorable position of the corresponding donor‐bridge moieties for better conjugation.
Open Pore Architecture of an Ordered Mesoporous IrO2 Thin Film for Highly Efficient Electrocatalytic Water Oxidation
Authors: Chandra Debraj , Abe Naoto , Takama Daisuke , Saito Kenji , Yui Tatsuto , Yagi Masayuki 
Published: February 2015

AbstractWe report the first accessible channel‐like open pore architecture of ordered 2D hexagonal mesoporous IrO2 films and its utilization as an efficient anode for electrocatalytic water oxidation. A well‐ordered mesostructure of circa 7 nm pores were obtained by a facile one‐pot soft‐templating strategy, employing a [Ir(OH)6]2− precursor stabilized by a triblock copolymer “Pluronic F127” as a pore‐directing template. A mesoporous IrO2 film calcined at 400 °C (∼70 nm thick) affords a high surface area of 512 m2 cm−3 and 2 times higher O2 evolution during the electrocatalytic water oxidation relative to an untemplated IrO2 coating film.
Reconciling nature conservation and traditional farming practices: a spatially explicit framework to assess the extent of High Nature Value farmlands in the European countryside
Authors: Lomba Angela , Alves Paulo , Jongman Rob H. G. , McCracken David I. 
Published: February 2015

Summary

Agriculture constitutes a dominant land cover worldwide, and rural landscapes under extensive farming practices acknowledged due to high biodiversity levels. The High Nature Value farmland (HNVf) concept has been highlighted in the EU environmental and rural policies due to their inherent potential to help characterize and direct financial support to European landscapes where high nature and/or conservation value is dependent on the continuation of specific low‐intensity farming systems.

Assessing the extent of HNV farmland by necessity relies on the availability of both ecological and farming systems' data, and difficulties associated with making such assessments have been widely described across Europe. A spatially explicit framework of data collection, building out from local administrative units, has recently been suggested as a means of addressing such difficulties.

This manuscript tests the relevance of the proposed approach, describes the spatially explicit framework in a case study area in northern Portugal, and discusses the potential of the approach to help better inform the implementation of conservation and rural development policies.

Synthesis and applications: The potential of a novel approach (combining land use/cover, farming and environmental data) to provide more accurate and efficient mapping and monitoring of HNV farmlands is tested at the local level in northern Portugal. The approach is considered to constitute a step forward toward a more precise targeting of landscapes for agri‐environment schemes, as it allowed a more accurate discrimination of areas within the case study landscape that have a higher value for nature conservation.
Mitochondria‐Targeting Photocytotoxic Ferrocenyl Conjugates of N‐Alkylpyridinium Salts
Authors: Balaji Babu , Balakrishnan Babita , Perumalla Sravanakumar , Karande Anjali A. , Chakravarty Akhil R. 
Published: February 2015

AbstractFerrocenyl (Fc) conjugates (1–3) of alkylpyridinium cations (E)‐N‐alkyl‐4‐[2‐(ferrocenyl)vinyl]pyridinium bromide (alkyl = n‐butyl in 1, N,N,N‐triethylbutan‐1‐aminium bromide in 2, and n‐butyltriphenylphosphonium bromide in 3) were prepared and characterized, and their photocytotoxicities and cellular uptakes in HeLa cancer and 3T3 normal cells were studied. The species with a 4‐methoxyphenyl moiety (4) instead of Fc was used as a control. The triphenylphosphonium‐appended 3 was designed for specific delivery into the mitochondria of the cells. Compounds 1–3 showed metal‐to‐ligand charge‐transfer bands at λ ≈ 550 nm in phosphate buffered saline (PBS). The Fc+/Fc and pyridinium core redox couples were observed at 0.75 and –1.2 V versus a saturated calomel electrode (SCE) in CH2Cl2/0.1 M (nBu4N)ClO4. Conjugate 3 showed a significantly higher photocytotoxicity in HeLa cancer cells [IC50 = (1.3 ± 0.2) μM] than in normal 3T3 cells [IC50 = (27.5 ± 1.5) μM] in visible light (400–700 nm). The positive role of the Fc moiety in 3 was evident from the inactive nature of 4. A JC‐1 dye (5,5,6,6‐tetrachloro‐1,1,3,3‐tetraethylbenzimidazolylcarbocyanine iodide) assay showed that 3 targets the mitochondria and induces apoptosis by the mitochondrial intrinsic pathway caused by reactive oxygen species (ROS). Annexin/propidium iodide studies showed that 3 induces apoptotic cell death in visible light by ROS generation, as evidenced from dichlorofluorescein diacetate assay. Compounds 1–3 exhibit DNA photocleavage activity through the formation of hydroxyl radicals.
Slow Magnetic Relaxation in Pseudo‐One‐Dimensional 2p‐4f Chains Involving π–π Interactions
Authors: Wang Juanjuan , Zhu Mei , Li Cun , Zhang Junqing , Li Licun 
Published: February 2015

AbstractThe reactions of the nitronyl nitroxide radical 2‐(p‐nitrophenyl)‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide (NIT‐PhNO2) with Ln(hfac)3 (hfac = hexafluoroacetylacetonate) afford two mononuclear lanthanide nitronyl nitroxide complexes [Ln(hfac)3(NIT‐PhNO2)2]·0.5C7H16 [Ln = GdIII (1), DyIII (2)]. X‐ray structural analysis shows that both complexes have a similar mononuclear structure, in which two NIT‐PhNO2 radicals are bonded to the LnIII center as monodentate ligands through the oxygen atoms of the NO groups. Interestingly, those mononuclear units form a pseudo‐one‐dimensional chain structure through π–π interactions. Direct current (dc) magnetic measurements show that there is ferromagnetic coupling between the lanthanide ion and the radical ligand for both complexes. Alternating current (ac) magnetic susceptibility studies reveal that the DyIII complex shows slow relaxation of magnetization in zero field, which is observed for the first time in a lanthanide–radical complex with a pseudo one‐dimensional structure through π–π interactions.
Rhodium‐Catalyzed Regioselective Direct C–H Amidation of 2,4‐Diarylquinazoline with Sulfonyl Azides: An Example of Steric Hindrance Regulated Mono‐ and Diamidation Selectivity
Authors: Zhang Chunyan , Zhou Yirong , Deng Zhihong , Chen Xin , Peng Yiyuan 
Published: February 2015

AbstractAn unprecedented steric hindrance controlled regioselective rhodium‐catalyzed direct C–H amidation of 2,4‐diarylquinazoline was described. Sulfonyl azides were used as the amine source to provide a variety of amide‐functionalized 2,4‐diarylquinazolines in high efficiency. The reaction proceeded under mild conditions, had good functional group tolerance with a broad scope of substrates, and afforded moderate to good product yields. Excellent monoamidation selectivity was achieved with the assistance of meta substituents.
Direct Vicinal Difunctionalization of Alkynes: An Efficient Approach Towards the Synthesis of Highly Functionalized Fluorinated Alkenes
Authors: Besset Tatiana , Poisson Thomas , Pannecoucke Xavier 
Published: February 2015

AbstractThe direct vicinal difunctionalization of versatile alkynes is an area of considerable interest. In particular, the concomitant introduction of a functional group and a fluorinated moiety offers new efficient synthetic routes to the construction of highly functionalized olefins, key building blocks in the synthesis of several complex and relevant molecules. This review highlights the major progress that has been made in this field offering an overview of the direct concomitant introduction of a range of functional groups and various fluorinated moieties into alkynes through radical and metal‐catalyzed processes. In addition, rearrangement reactions involving molecules containing alkynes and leading to fluorinated alkenes are also carefully depicted.
Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures
Authors: Zhang Yongqiang , Wu Shanchao , Wang Shengzheng , Fang Kun , Dong Guoqiang , Liu Na , Miao Zhenyuan , Yao Jianzhong , Li Jian , Zhang Wannian , Sheng Chunquan , Wang Wei 
Published: February 2015

AbstractA powerful divergent cascade strategy has been explored for the easy construction of diverse enantioenriched pyrazole‐derived scaffolds from readily available chiral fused pyrazole‐tetrahydropyran acetals. These versatile intermediates can react in various ways to give Michael–aldol, reduction–lactonization, α‐hydroxylation–acetalization–oxidation, and Wittig–aldol and Wittig–oxa‐Michael cascade reactions. Using only six simple building blocks, these processes gave five distinct molecular architectures. Furthermore, screening 10 compounds representing the 5 distinct scaffolds revealed potent anticancer lead compounds that deserve further development.
Relative sensitivity of an amphipod Hyalella azteca, a midge Chironomus dilutus, and a unionid mussel Lampsilis siliquoidea to a toxic sediment
Authors: Ingersoll Chris G. , Kunz James L. , Hughes Jamie P. , Wang Ning , Ireland D. Scott , Mount David R. , Hockett J. Russell , Valenti Theodore W. 
Published: February 2015

Abstract

The objective of the present study was to evaluate the relative sensitivity of test organisms in exposures to dilutions of a highly toxic sediment contaminated with metals and organic compounds. One dilution series was prepared using control sand (low total organic carbon [TOC; &lt;0.1%, low binding capacity for contaminants]) and a second dilution series was prepared using control sediment from West Bearskin Lake, Minnesota, USA (high TOC [∼10% TOC, higher binding capacity for contaminants]). Test organisms included an amphipod (Hyalella azteca; 10-d and 28-d exposures), a midge (Chironomus dilutus; 20-d and 48-d exposures started with &lt;1-h-old larvae, and 13-d and 48-d exposures started with 7-d-old larvae), and a unionid mussel (Lampsilis siliquoidea; 28-d exposures). Relative species sensitivity depended on the toxicity endpoint and the diluent. All 3 species were more sensitive in sand dilutions than in West Bearskin Lake sediment dilutions. The &lt;1-h-old C. dilutus were more sensitive than 7-d-old C. dilutus, but replicate variability was high in exposures started with the younger midge larvae. Larval biomass and adult emergence endpoints of C. dilutus exhibited a similar sensitivity. Survival, weight, and biomass of H. azteca were more sensitive endpoints in 28-d exposures than in 10-d exposures. Weight and biomass of L. siliquoidea were sensitive endpoints in both sand and West Bearskin Lake sediment dilutions. Metals, ammonia, oil, and other organic contaminants may have contributed to the observed toxicity. Environ Toxicol Chem 2015;34:1134–1144. © 2015 The Authors. Published by SETAC.
Microplastics: addressing ecological risk through lessons learned
Authors: Syberg Kristian , Khan Farhan R. , Selck Henriette , Palmqvist Annemette , Banta Gary T. , Daley Jennifer , Sano Larissa , Duhaime Melissa B. 
Published: February 2015

Abstract

Plastic litter is an environmental problem of great concern. Despite the magnitude of the plastic pollution in our water bodies, only limited scientific understanding is available about the risk to the environment, particularly for microplastics. The apparent magnitude of the problem calls for quickly developing sound scientific guidance on the ecological risks of microplastics. The authors suggest that future research into microplastics risks should be guided by lessons learned from the more advanced and better understood areas of (eco) toxicology of engineered nanoparticles and mixture toxicity. Relevant examples of advances in these two fields are provided to help accelerate the scientific learning curve within the relatively unexplored area of microplastics risk assessment. Finally, the authors advocate an expansion of the “vector effect” hypothesis with regard to microplastics risk to help focus research of microplastics environmental risk at different levels of biological and environmental organization. Environ Toxicol Chem 2015;34:945–953. © 2015 SETAC
Water productivity of poultry production: the influence of different broiler fattening systems
Authors: Krauß Michael , Keßler Jens , Prochnow Annette , Kraatz Simone , Drastig Katrin 
Published: February 2015

AbstractWith the expected increase in poultry meat consumption water use will increase as well. The objective of this study is to quantify the effects of fattening systems on the water productivity in broiler chicken production with consideration given to conditions in Germany. Four fattening systems were analyzed in terms of water use for feed production, drinking, cleaning, and the parent stock. The fattening systems differed in intensity, ranging from fast fattening with a fattening period of 30 days and a carcass weight of 1.1 kg to slow fattening with a period up to 46 days and a carcass weight of 2.1 kg. During the fattening period the broiler chicken were fed with performance‐linked feed. The water productivity of the feed components varied from 0.4 kg dry mass per m3 water input for soybean meal to 1.8 kg dry mass per m3 water input for maize. In all fattening systems the water input for feed production accounted for 90 to 93% of the total water input. The share for the parent stock was 7 to 10%, while drinking and cleaning water accounted for less than 1%. For all fattening systems the water productivity was 0.3 kg carcass weight per m3 water input, 2.8 MJ food energy per m3 water input and 57 g food protein per m3 water input. The shorter fattening period and lower feed demand in the more intensive fattening systems were juxtaposed to the higher carcass weight and higher water productivity of the feed components in the more extensive systems.
Exploring the brain's structural connectome: A quantitative stroke lesion‐dysfunction mapping study
Authors: Kuceyeski Amy , Navi Babak B. , Kamel Hooman , Relkin Norman , Villanueva Mark , Raj Ashish , Toglia Joan , O'Dell Michael , Iadecola Costantino 
Published: February 2015

AbstractThe aim of this work was to quantitatively model cross‐sectional relationships between structural connectome disruptions caused by cerebral infarction and measures of clinical performance. Imaging biomarkers of 41 ischemic stroke patients (72.0 ± 12.0 years, 20 female) were related to their baseline performance in 18 cognitive, physical and daily life activity assessments. Individual estimates of structural connectivity disruption in gray matter regions were computed using the Change in Connectivity (ChaCo) score. ChaCo scores were utilized because they can be calculated using routinely collected clinical magnetic resonance imagings. Partial Least Squares Regression (PLSR) was used to predict various acute impairment and activity measures from ChaCo scores and patient demographics. Statistical methods of cross‐validation, bootstrapping and multiple comparisons correction were implemented to minimize over‐fitting and Type I errors. Multiple linear regression models based on lesion volume and lateralization information were constructed for comparison. All models based on connectivity disruption had lower Akaike Information Criterion and almost all had better goodness‐of‐fit values (R2: 0.26–0.92) than models based on lesion characteristics (R2: 0.06–0.50). Confidence intervals of PLSR coefficients identified brain regions important in predicting each clinical assessment. Appropriate mapping of eloquent functions, that is, language and motor, and replication of results across pathologies provided validation of this method. Models of complex functions provided new insights into brain‐behavior relationships. In addition to the potential applications in prognostication and rehabilitation development, this quantitative approach provides insight into the structural networks underlying complex functions like activities of daily living and cognition. Quantitative analysis of big data will be invaluable in understanding complex brain‐behavior relationships. Hum Brain Mapp 36:2147–2160, 2015. © 2015 Wiley Periodicals, Inc.
Identification of a sustained neurogenic zone at the dorsal surface of the adult mouse hippocampus and its regulation by the chemokine SDF‐1
Authors: Belmadani Abdelhak , Ren Dongjun , Bhattacharyya Bula J. , Rothwangl Katharina B. , Hope Thomas J. , Perlman Harris , Miller Richard J. 
Published: February 2015

ABSTRACTWe identified a previously unknown neurogenic region at the dorsal surface of the hippocampus; (the “subhippocampal zone,” SHZ) in the adult brain. Using a reporter mouse in which SHZ cells and their progeny could be traced through the expression of EGFP under the control of the CXCR4 chemokine receptor promoter we observed the presence of a pool of EGFP expressing cells migrating in direction of the dentate gyrus (DG), which is maintained throughout adulthood. This population appeared to originate from the SHZ where cells entered a caudal migratory stream (aCMS) that included the fimbria, the meninges and the DG. Deletion of CXCR4 from neural stem cells (NSCs) or neuroinflammation resulted in the appearance of neurons in the DG, which were the result of migration of NSCs from the SHZ. Some of these neurons were ectopically placed. Our observations indicate that the SHZ is a neurogenic zone in the adult brain through migration of NSCs in the aCMS. Regulation of CXCR4 signaling in these cells may be involved in repair of the DG and may also give rise to ectopic granule cells in the DG in the context of neuropathology. © 2015 Wiley Periodicals, Inc.
Synthesis and Structure of a Ternary Copper(II) Complex with Mixed Ligands of Diethylenetriamine and Picrate: DNA/Protein‐Binding Property and In Vitro Anticancer Activity Studies
Authors: Shi Ya‐Ning , Zheng Kang , Zhu Ling , Li Yan‐Tuan , Wu Zhi‐Yong , Yan Cui‐Wei 
Published: February 2015

ABSTRACTBased on the importance of the design and synthesis of transition metal complexes with noncovalent DNA/protein‐binding abilities in the field of metallo pharmaceuticals, a new mononuclear ternary copper(II) complex with mixed ligands of diethylenetriamine (dien) and picrate anion (pic), identified as [Cu(dien)(pic)](pic), was synthesized and characterized by elemental analysis, molar conductivity measurement, infrared spectrum, electronic spectral studies, and single‐crystal X‐ray diffractometry. The structure analysis reveals that the copper(II) complex crystallizes in the monoclinic space group P21/c, and the copper(II) ion has a distorted square pyramidal coordination geometry. A two‐dimensional supramolecular structure is formed through hydrogen bonds. The DNA/bovine serum albumin (BSA)‐binding properties of the complex are explored, indicating that the complex can interact with herring sperm DNA via intercalation mode and bind to BSA responsible for quenching of tryptophan fluorescence by static quenching mechanism. The in vitro anticancer activity shows that the copper(II) complex is active against the selected tumor cell lines.