bluuebunny/crossref_metadata_2025_split huggingface dataset:
VEGF-B promotes cancer metastasis through a VEGF-A–independent mechanism and serves as a marker of poor prognosis for cancer patients
Authors: Yang Xiaojuan , Zhang Yin , Hosaka Kayoko , Andersson Patrik , Wang Jian , Tholander Fredrik , Cao Ziquan , Morikawa Hiromasa , Tegnér Jesper , Yang Yunlong , Iwamoto Hideki , Lim Sharon , Cao Yihai 
Published: May 2015

Significance
Cancer metastasis is responsible for a majority of the mortality in cancer patients and involves complex interactions, modulated by various factors and cytokines, between malignant and host cells. Vascular structures in solid tumors are crucial for cancer cell intravasation into the circulation. Our present work shows that VEGF-B produced by tumor cells significantly remodels tumor microvasculature, leading to leaky vascular networks that are highly permissive for tumor cell invasion. VEGF-B–promoted cancer metastasis occurs through a VEGF-A–independent mechanism. Thus, inhibition of VEGF-B should be considered an independent approach for the development of new drugs for the treatment of cancer invasion and metastasis. VEGF-B also may be considered as an independent prognostic marker for cancer metastasis.
Cd accumulation potential as a marker for heavy metal tolerance in soybean
Authors: Socha Peter , Bernstein Nirit , Rybanský Ĺubomír , Mészáros Patrik , Gálusová Terézia , Spieß Nadine , Libantová Jana , Moravčíková Jana , Matušíková Ildikó 
Published: May 2015

Plants have a potential for the uptake and accumulation of essential and non-essential trace elements. The ability to take up and tolerate metals varies between and within species as well as between metals. For most metals, the mechanisms involved in plant tolerance, uptake and accumulation are still not fully known and it is not known to what extent the plant response is metal-specific rather than a general stress response. In the present study, the growth response of soybean to Cd, As, Al and NaCl was compared and contrasted to simple sequence repeat (SSR) marker analysis results for Cda1, a dominant gene located in a major quantitative trait locus that regulates Cd accumulation in soybean, to evaluate the hypothesis that general effect patterns are induced by the individual metals. Principal component analysis revealed that the root growth response was most diverse for Al exposure and decreased in the order of Al > As > Cd > NaCl. NaCl did not exert a differentiating effect, indicating response mechanisms similar, at least partially, to metal exposure. The applied stressors yielded a distinguishable pattern of root responses, indicating the potential of such screens to identify agents acting similarly or differently. The SSR marker analysis also facilitated characterization of the Cd accumulation potential of the 22 soybean cultivars studied, and thereby identification of cultivars with potential health risk under cultivation in Cd-contaminated soils.
DSigDB: drug signatures database for gene set analysis
Authors: Yoo Minjae , Shin Jimin , Kim Jihye , Ryall Karen A. , Lee Kyubum , Lee Sunwon , Jeon Minji , Kang Jaewoo , Tan Aik Choon 
Published: May 2015

Abstract
Summary: We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.
Availability and implementation: DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB.
Supplementary information: Supplementary data are available at Bioinformatics online.
Contact: aikchoon.tan@ucdenver.edu
Self and world in lay interpretations of climate change
Authors: Denniss Rebecca Joy , Davison Aidan 
Published: May 2015

Purpose
– This paper aims to report on an in-depth qualitative study that focuses on the convergence of the interpretive activities of knowing, living in and valuing the world in lay reasoning about climate change. Although awareness is growing that lay people interact with scientific knowledge about climate change in complex ways, relatively little is known about this interaction. Much quantitative research on public attitudes to climate change does little to draw out the cognitive and experiential processes by which lay people arrive at understandings of climate change.

Design/methodology/approach
– Through narrative analysis of qualitative interviews, this paper examines lay rationalities of climate change as a process of not only knowing the world (epistemology), but of being oriented towards the world (ontology) and valuing the world (axiology).

Findings
– The findings emphasise the extent of individual variation in lay interpretations of climate change, and their internal complexity. Almost all participants display differences in reasoning about climate change when considering their personal lives as compared to the wider, public world. Distinct accounts of self and world in lay rationalities are evident in the ways that participants imagine the future and express their feelings of culpability for and responsibility to act on climate change.

Originality/value
– This paper argues that lay reasoning about climate science does not just engage ways of knowing the world but also ways of being in and valuing the world so as to open up multiple trajectories for comprehension.
Climate change and military planning
Authors: Brzoska Michael 
Published: May 2015

Purpose– The paper aims to investigate the consequences of climate change for the future of armed forces and their presentation in national security documents.Design/methodology/approach– A classification of potential future military roles and functions is derived from relevant literature, resulting in six “military futures”. Frames are developed for these whose occurrence is counted in 53 authoritative documents on security policy and defense planning from 38 countries. Results are presented in descriptive statistics.Findings– The paper demonstrates that climate change has become an important issue for military planning. However, the directions in which it takes thinking about the future of armed forces differ widely. Among the six “military futures” identified, those linked to the function of disaster relief are most frequently found. However, the expansion of traditional military roles is also promoted. Rarer are suggestions for armed forces to became “greener” or “leaner”. In general, climate change provides an additional justification for continuing established paths for military planning.Originality/value– The paper makes two contributions to the existing literature. First, it provides a classification of potential future consequences of climate change for armed forces. Second, it empirically establishes, for a set of authoritative documents, the relative importance of differing expectation of the effects of climate change on the structure and functions of militaries.
Sharing the burden of financing the green climate fund in the Post-Kyoto era
Authors: Cui Lianbiao , Gui Huangbao 
Published: May 2015

Purpose
– The purpose of this paper is to design several methods for enforcing developed countries’ responsibilities under the Green Climate Fund (GCF). The GCF has been one of the core subjects of the world climate summits held under the United Nations Framework Convention on Climate Change. However, the development of the GCF has not progressed smoothly, and many concerns remain unresolved.

Design/methodology/approach
– This paper illustrates three approaches for financing the GCF that vary in terms of the relative weights accorded to environmental responsibility and economic capacity. These three methods include the historical responsibility (HR) principle, the ability to pay (AP) principle and the preference score compromises (PSC) approach (which is a combination of the HR and the AP principles).

Findings
– The empirical analysis demonstrates that the USA is the largest contributor to the GCF under the HR principle due to the volume of its historical emissions, whereas the European Union bears the greatest financial responsibility under the AP principle, based on its gross domestic product. Under the PSC approach, the European Union and the USA each undertakes a financial burden that approximates 40 per cent of the total financing for the GCF. These nations are followed by Japan, which has a share of almost 9 per cent.

Originality/value
– This study is the first attempt to introduce the PSC concept into discussions regarding GCF financing. A scheme of burden sharing that combines environmental responsibility and economic capacity factors is developed and introduced. The respective weights assigned to the two factors are determined based on the Borda rule in voting theory, which avoids the arbitrary allocation of weights between the HR and the AP. These findings will be useful for mobilising the GCF in the Post-Kyoto era.
The impact on educational technology of a fatal airline accident: a case study
Authors: Brady Tim 
Published: May 2015

Purpose
– The purpose of this paper is to study of how a virtual technology burden was created that impacted the professional pilot college student and various colleges/universities that offer professional pilot degree programs. A cascading set of events began as a result of US congressional reaction to a tragic airline accident. The resulting legislation forced the Federal Aviation Administration to publish new rules for first officer qualifications that were unmindful of the recommendations of professional pilot groups for simulation-based training. Ultimately, this placed a financial burden on both the college/university training curriculum and on the professional pilot student.

Design/methodology/approach
– This paper adopts a case study approach.

Findings
– Because of US congressional over-reaction, a collegiate system which produced excellent first officer candidates who had below 500 flight hours and who had been demonstrated scientifically to be efficient, skilled, and safe, was upended. The flight hour requirements were increased fivefold with little regard to its impact on the pilot pool. Congressional legislation forced the FAA to create and publish new rules that were unmindful of the simulation recommendations of professional pilot groups and required virtual simulation technology new to the college/university training environment.

Originality/value
– Traces the effect of government interference into a previously stable continuum of college-prepared airline pilots who are safe and effective.
Designing the online oral language learning environment SpeakApps
Authors: Nic Giolla Mhichíl Mairéad , Appel Christine , Ó Ciardubháin Colm , Jager Sake , Prizel-Kania Adriana 
Published: May 2015

Purpose
– The purpose of this paper is to report on SpeakApps, a major collaborative computer-assisted language learning project, developed based on an open source techno-pedagogical solution to facilitate online oral language production and interaction.

Design/methodology/approach
– A mixed method approach was incorporated as part of the development process which included a comprehensive literature and practice review, user requirement survey of 815 learner, 61 pilot studies with 7,180 students, construction of qualitative teaching scenarios and a Delphi analysis.

Findings
– Language learners have limited experience of using synchronous communication tools within language learning contexts. Improving usability features within the Open Educational Resources supported the notion of sustainability and that the provision of the mechanism to indicate quality were vital to support the integrity of open content.

Originality/value
– The paper provides an overview of the operationalisation of an action-oriented approach to language learning which manifested as a design for learning development process. It illustrates the breadth of issues raised from technical to pedagogical when teacher and learner agency are central for development and sustainability.
Cooperative purchase and use: a study of the ProQuest full text database of dissertations and theses (PQDT)
Authors: Yao Xiaoxia , Zhao YongChao 
Published: May 2015

Purpose
– To purpose of this study is to describe and to demonstrate the value of a consortium purchase of the ProQuest Dissertations and Theses full-text database (PQDT) in China.

Design/methodology/approach
– The authors provide a first-person account based on their professional positions at the China Academic Library & Information System Administrative Center.

Findings
– That the PQDT database has steadily increased the use of theses in China with more institutions subscribing every year. The PQDT full-text database has become one of the most cost effective databases cooperatively purchased in China.

Originality/value
– One of the few in-depth studies of the use of the PQDT database.
Open Doors: library cross-sector co-operation in Bristol, UK
Authors: Chelin Jacqueline Ann 
Published: May 2015

Purpose
– This paper outlines the aims, activities and outcomes of a project to pilot a reciprocal borrowing scheme between public and academic libraries using existing cards, i.e. public library cards in the academic library and university ID cards in the public libraries.

Design/methodology/approach
– This is a case study providing practical information about the establishment and promotion of the service, and recounting the feedback from surveys of participants, prospective users and library staff.

Findings
– The project outcomes indicate that the reciprocal use of existing library cards between institutions and public libraries in a geographical area: was relatively simple once set up; was appreciated by all those who participated; had few teething problems; had had no appreciable impact on the availability of academic stock to University of the West of England (UWE) students; increased public library and academic library usage by target groups, e.g. school students 16 years and over, enabled the public library service to provide a significantly better offer of resources to its community, especially those who needed access to specialised stock, not normally available in a general public library service.

Originality/value
– The partnership between LibrariesWest (led by South Gloucestershire Libraries) and UWE Bristol Library Services is not unusual. However, the approach taken, i.e. to allow borrowers to use their own libraries’ cards without any data sharing between the respective systems, is fairly unique. The processes involved and the evaluation of the scheme are of value to other prospective partnerships where organisations are geographically aligned.
When small businesses go international: alliances as a key to entry
Authors: Haase Heiko , Franco Mário 
Published: May 2015

Purpose
– The purpose of this study is to identify the reasons for the internationalisation of small and medium-sized enterprises (SMEs) through strategic alliances and to understand how this internationalisation process evolves.

Design/methodology/approach
– For this purpose, the authors decided on a qualitative approach and performed exploratory case studies of two SMEs in Portugal.

Findings
– The authors found that in forming alliances, SMEs aim to increase sales and reduce costs. After the analysis, the authors believe that learning about other markets and cultures as well as having appropriate national partners are the key aspects in the internationalisation of SMEs through strategic alliances.

Practical implications
– The authors revealed the influence of national partners in the internationalisation process. The firms in the study established alliances with national firms to facilitate international market entry. This holds in particular for partners that already have some international experience. Building partnerships with national firms allows the combination of competencies and requires a lower amount of internationalisation know-how on the part of the cooperating firms.

Originality/value
– In spite of the opportunities going along with strategic alliances, there is only limited empirical evidence of their impact on the internationalisation process and vice-versa. This holds particularly true for the realm of SMEs.
Towards the comprehensive and systematic assessment of the adaptive reuse of Islamic architectural heritage in Cairo
Authors: Shehata Waleed Tarek Ali , Moustafa Yasser , Sherif Lobna , Botros Ashraf 
Published: May 2015

Purpose
– Many of the heritage adaptive reuse projects in Islamic Cairo did not report success. Existing evaluations are usually drawn from a singular perspective – such as preservation and sustainability. The purpose of this paper is to generate a comprehensive assessment framework of adaptively reused heritage buildings that is specifically developed for the case of Islamic heritage of Cairo.

Design/methodology/approach
– This paper depends on an extensive literature review about primary goals of adapting heritage for reuse. Related to each goal, multiple criteria of assessment are derived from literature, and then explained to mention worldwide benchmarks in that field.

Findings
– A successful heritage adaptation project shall aim to achieve: building preservation, success of new function, and local community development. The framework is able to organize the adaptive reuse literature in general, and to specifically provide direct goals and guidelines in the case of Cairo.

Research limitations/implications
– In research and practice, priorities of heritage reuse vary from case-to case; however, this paper considers all assessment criteria to be of equal importance.

Practical implications
– In order to apply and technically develop this assessment framework, future research can describe methodologies for assessment and to set optimum quantitative and/or qualitative indicators’ thresholds for each criterion.

Social implications
– This paper highlights that new uses of heritage buildings should be assessed for having a role in the upgrading the socio-economic milieu of the people living. The new functions shall act as a stimulant for economic upraising and social reinforcement for the local business and small traditional industries.

Originality/value
– The framework can be used as a checklist in either the planning of adaptive reuse projects or the evaluation of already completed ones. The framework shall assist governmental institutions, developers, owners, community groups, practitioners, and others in bringing forward successful adaptation schemes in Cairo.
Dynamic integrity: a concept to historic urban landscape
Authors: Mendes Zancheti Silvio , Piccolo Loretto Rosane 
Published: May 2015

Purpose
– The purpose of this paper is to set out a proposal for the concept of dynamic integrity. It is a heritage quality that may be attributed to heritage properties whose attributes are capable to express past and present meanings, and therefore values, in a context of change, without relying exclusively on records of memory. So, dynamic integrity (DI) emphasizes continuity in changing urban context and may be a key concept for the new Historic Urban Landscape (HUL) approach.

Design/methodology/approach
– The concept of DI was developed using theory of complexity to critic the existing definitions of integrity and their use to in context of urban heritage area under the pressure for change.

Findings
– The current concept of integrity, adopted by heritage field of knowledge, is not capable to deal with the complexity of the HUL. There is a tendency to define conservation as the regulation or control of change. This assumption is problematic since it emphasizes the changes of meanings, values and attributes, instead of the idea of continuity. Controlling change means fixing the attributes that express the meanings of heritage areas, and this is a task fated to be unsuccessful in complex cities or, even in not so complex urban sites.

Originality/value
– It is the first time that the concept of integrity has been put to explain and manage the dynamics of urban heritage areas.
Ecomuseum, community museology, local distinctiveness, Hüsamettindere village, Bogatepe village, Turkey
Authors: Dogan Mustafa 
Published: May 2015

Purpose
– The concept of sustainable development is now widely accepted as a means of protecting natural resources and cultural heritage. One approach to ensuring sustainability, especially in relation to cultural tourism, is the ecomuseum. Turkey has considerable potential to develop ecomuseological models to encourage local sustainable development. The purpose of this paper is to explore the development of ecomuseums in Turkey by analysing the recent implementation of the concept in Hüsamettindere and Bogatepe villages. Current practices at these two sites are evaluated in comparison with the basic principles of ecomuseum theory.

Design/methodology/approach
– This paper explores local community involvement in two emerging ecomuseums in Turkey based on several years of participant action research by the author; it describes the nature of the two ecomuseums based on that experience. In addition an in-depth survey was carried out between February and April 2013 by Canakkale Onsekiz Mart University when 45 local participants were interviewed for their views on the ecomuseum developments, using the MACDAB method (Borrelli et al., 2008) as a guide.

Findings
– Even though the two implementations in Turkey have different features deriving from their local dynamics, they have had a similar experience in terms of the development process. Both began with a volunteer movement, the organisation of the local community, the formation of civil initiatives, a joint decision-making processes and the existence of participation and consensus. This process conforms to the basic principles of ecomuseology. The ecomuseums have also raised concerns about the loss of rural heritage and the mechanisms for conserving it within the model of the “living” ecomuseum. The most significant fact to emerge from this initial review of the two ecomuseums is that it is not necessarily their ability to conserve fragments of tangible and intangible heritage that is paramount in Turkey, but their importance in providing employment opportunities in rural areas.

Originality/value
– Ecomuseum movement is a very important and practical model for sustainable development and tourism. Ecomuseums can also be functional tools for protecting of cultural heritage and developing of local areas. Even though Turkey has got many cultural heritage sources, they are not used productively for local sustainable development. The two implementations will be sample to all natural and cultural heritage areas of Turkey for sustainable development.