bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation, cross‐cultural adaptation and validation of the Quality of Life Evaluation in Epidermolysis Bullosa instrument in Brazilian Portuguese
Authors: Cestari Tania , Prati Clarissa , Menegon Doris B. , Prado Oliveira Zilda N. , Machado Maria Cecília R. , Dumet Juliana , Nakano Juliana , Murrell Dédée F. 
Published: October 2015

AbstractBackgroundThe Quality of Life Evaluation in Epidermolysis Bullosa (QoLEB) questionnaire was developed for use in English‐speaking individuals.ObjectivesThe aims of this study were to translate the QoLEB into Brazilian Portuguese, to culturally adapt it, and to verify its reliability and validity.MethodsThe study followed the steps proposed by the World Health Organization, which include: translation; evaluation by a panel of experts and patients; back translation; and linguistic and cultural adaptation. All subjects were examined and assessed using the QoLEB and the Dermatology Life Quality Index (DLQI) or the Children's Dermatology Life Quality Index (CDLQI). Translation and cultural and linguistic adaptation were conducted by 10 patients, three translators, and the bilingual authors.ResultsThe population was composed of 40 children (mean age: 8,15 years) and 17 adults (mean age: 33 years). Among the children, eight had epidermolysis bullosa (EB) simplex (EBS), one had junctional EB (JEB), and 31 had dystrophic EB (DEB). In the adult group, four of the subjects had EBS, one had JEB, and 12 had DEB. Mean ± standard deviation (SD) scores on the QoLEB in children were 10.60 ± 7.13 in EBS subjects, 9.71 ± 7.87 in children with dominant DEB (DDEB), and 14.25 ± 9.67 in children with recessive DEB (RDEB). Mean ± SD scores in adults were 12.50 ± 9.95 in EBS subjects, 12.00 ± 5.83 in DDEB subjects, and 20.20 ± 9.21 in RDEB subjects. The QoLEB‐BP (Brazilian Portuguese) showed high internal consistency (Cronbach's α = 0.88) and high test–retest reliability (intraclass correlation coefficient: 0.70), confirming the internal consistency and reproducibility of this Portuguese version. There were significant correlations between QoLEB scores and both CDLQI (Pearson's r = 0.688, P < 0.002) and DLQI (Pearson's r = 0.807, P < 0.001) scores.ConclusionsEpidermolysis bullosa has marked impacts on the lives of EB patients and their families, which are strongly correlated with disease severity. The Brazilian Portuguese version of the QoLEB is validated and can be recommended for use in subsequent studies.
Quantification of sweat secretion in focal axillary hyperhidrosis related to area and time: the hyperhidrosis area and secretion index
Authors: Bahmer Friedrich A. 
Published: October 2015

AbstractBackgroundSeverity of focal axillary hyperhidrosis (FAH) hitherto is estimated semiquantitatively by weighting the secreted sweat with the sweating area visualized by iodine starch test. In this study, we quantified secretion (mg/cm2 per min) simply by estimating the sweating area morphometrically via point counting. We have named the numeric value obtained the hyperhidrosis area and secretion index (HASI).MethodsIn 183 patients (146 women, 37 men) with focal axillary hyperhidrosis, seen in a city hospital outpatient clinic, sweat secretion was assessed by gravimetry and the area of Minor's iodine–starch test determined by point counting. Values were analyzed with respect to gender, age, and body surface area.ResultsHASI values, combined for both axillae, ranged from 0.21 to 22.8 mg/cm2 per minute with only minor gender differences. Men had larger sweating areas than women did. The comparison of left to right side axillae did not disclose substantial differences. No correlation was found between age and HASI values. A subgroup analysis of 91 patients showed a good correlation of HASI values with body surface area.ConclusionHASI allows for a quantification of sweat secretion per time interval and area unit, thus facilitating pre‐ and post‐test assessment of sweat intensity as well as a comparison between the results of different studies.
The effects of the El Niño Southern Oscillation on skin and skin‐related diseases: a message from the International Society of Dermatology Climate Change Task Force
Authors: Andersen Louise K. , Davis Mark D. P. 
Published: October 2015

AbstractThe El Niño Southern Oscillation (ENSO) is a complex climate phenomenon occurring in the Pacific Ocean at intervals of 2–7 years. The term refers to fluctuations in ocean temperatures in the tropical eastern Pacific Ocean (El Niño [the warm phase of ENSO] and La Niña [the cool phase of ENSO]) and in atmospheric pressure across the Pacific basin (Southern Oscillation). This weather pattern is attributed with causing climate change in certain parts of the world and is associated with disease outbreaks. The question of how ENSO affects skin and skin‐related disease is relatively unanswered. We aimed to review the literature describing the effects of this complex weather pattern on skin. El Niño has been associated with increases in the occurrence of actinic keratosis, tinea, pityriasis versicolor, miliaria, folliculitis, rosacea, dermatitis by Paederus irritans and Paederus sabaeus, and certain vector‐borne and waterborne diseases, such as dengue fever, leishmaniasis, Chagas' disease, Barmah Forest virus, and leptospirosis, and with decreases in the occurrence of dermatitis, scabies, psoriasis, and papular urticaria. La Niña has been associated with increases in the occurrence of varicella, hand, foot, and mouth disease, and Ross River virus (in certain areas), and decreases in viral warts and leishmaniasis. Reports on the effects of ENSO on skin and skin‐related disease are limited, and more studies could be helpful in the future.
Issues Most Important to Parents After Their Children's Suicide Attempt: A Pilot Delphi Study
Authors: Hickey Kari , Rossetti Jeanette , Strom Jan , Bryant Kelly 
Published: October 2015

ProblemSuicide is the third leading cause of death for people aged 15–24 and results in 4,600 lives lost each year. One important risk factor for completed suicide is a nonlethal suicide attempt. To date, little research has been conducted on the needs of parents of adolescents who have made a nonlethal suicide attempt.MethodsThe goal of this pilot study was to describe the most important concerns of parents whose children have made a nonlethal suicide attempt from the perspective of adolescent mental health professionals. A two‐round Delphi technique was utilized with an interdisciplinary panel of adolescent mental health experts to gain consensus on what issues are most important to parents after their children's suicide attempt.FindingsPanelists described the following as most important to parents after their children's nonlethal suicide attempt: keeping their children safe; identifying what caused or triggered the suicide attempt; strategies to prevent another suicide attempt; and communication and building trust for the future.ConclusionsAn advanced understanding of the issues most important to parents whose children have made a nonlethal suicide attempt has implications for clinicians in creating acceptable and useful interventions aimed at preventing youth suicide.
Longitudinal effects of systemic inflammation markers on periodontitis
Authors: Pink Christiane , Kocher Thomas , Meisel Peter , Dörr Marcus , Markus Marcello R. P. , Jablonowski Lukasz , Grotevendt Anne , Nauck Matthias , Holtfreter Birte 
Published: October 2015

AbstractAimSystemic low‐grade inflammation represents a central hallmark of chronic diseases and has been proposed as the underlying mechanism linking factors like obesity or diabetes with periodontitis. However, the impact of inflammatory markers on periodontitis has not yet been investigated.Materials and MethodsThe study population comprised 1784 subjects from the Study of Health in Pomerania with complete 11‐year follow‐up. Fibrinogen and white blood cell (WBC) counts were measured as markers of inflammation. Periodontitis was assessed by probing depth (PD), clinical attachment loss (CAL) and the CDC/AAP case definition.ResultsMultilevel regression analyses revealed significant coefficients for the impact of both inflammation markers on the percentage of sites with PD/CAL ≥ 3 mm. Increases in fibrinogen about 1 g/l were associated with 3.0% and 2.7% more sites with PD/CAL ≥ 3 mm respectively. Consistent associations were found using mean values of PD/CAL but not using missing teeth or caries. Regarding the CDC/AAP case definition, 11‐year changes in fibrinogen and WBC counts were significantly associated with ≥1 category progression (OR: 1.36 and 1.11).ConclusionsFibrinogen levels and WBC counts showed consistent long‐term associations with PD, CAL and the CDC/AAP case definition. Results indicate that systemic low‐grade inflammation might indeed represent one possible pathway for effects of obesity, diabetes or other chronic inflammatory conditions on periodontitis.
2'‐Hydroxyflavanone ameliorates mesenteric angiogenesis and portal‐systemic collaterals in rats with liver fibrosis
Authors: Hsin I‐Fang , Lee Jing‐Yi , Huo Teh‐Ia , Lee Fa‐Yauh , Huang Hui‐Chun , Hsu Shao‐Jung , Wang Sun‐Sang , Ho Hsin‐Ling , Lin Han‐Chieh , Lee Shou‐Dong 
Published: October 2015

AbstractBackground and AimPortal‐systemic collaterals lead to dreadful consequences in patients with cirrhosis. Angiogenesis participates in the development of liver fibrosis, hyperdynamic circulation, and portal‐systemic collaterals. 2′‐Hydroxyflavanone (2′‐HF), one of the citrus fruits flavonoids, is known to have antiangiogenesis effect without adverse response. However, the relevant effects in liver fibrosis have not been surveyed.MethodsMale Wistar rats received thioacetamide (TAA, 100 mg/kg tiw, i.p.) for 6 weeks to induce liver fibrosis. On the 29th to 42nd day, rats randomly received 2′‐HF (100 mg/kg, qod, i.p.) or vehicle (corn oil). On the 43rd day, after hemodynamic measurements, the followings were surveyed: (i) severity of collaterals; (ii) mesenteric angiogenesis; (iii) mesenteric proangiogenic factors protein expressions; (iv) Mesenteric vascular endothelial cells apoptosis; and (v) Mesenteric expressions of proteins regulating apoptosis.ResultsCompared with the vehicle group, 2′‐HF did not significantly change body weight, mean arterial pressure, heart rate, and portal pressure in TAA rats. 2′‐HF significantly alleviated the severity of collaterals, but the mesenteric phospho‐ERK, ERK, phospho‐Akt, Akt, COX1, COX2, VEGF, and VEGFR‐2 protein expressions were not altered. The apoptotic index of 2′‐HF group was significantly higher and the mesenteric protein expressions of pro‐apoptotic factors, NFkB 50, NFkB 65, Bax, phospho‐p53, 17 kD cleaved caspase 3, and 17 kD casepase 3 were up‐regulated.Conclusions2′‐HF does not influence the hemodynamics but alleviated the severity of collaterals in rats with liver fibrosis and early portal hypertension. This is, at least partly, attributed to enhanced apoptosis of mesenteric vascular endothelial cells.
Evolution and protein interactions of AP2 proteins in Brassicaceae: Evidence linking development and environmental responses
Authors: Zeng Liping , Yin Yue , You Chenjiang , Pan Qianli , Xu Duo , Jin Taijie , Zhang Bailong , Ma Hong 
Published: October 2015

AbstractPlants have evolved a large number of transcription factors (TF), which are enriched among duplicate genes, highlighting their roles in complex regulatory networks. The APETALA2/EREBP‐like genes constitute a large plant TF family and participate in development and stress responses. To probe the conservation and divergence of AP2/EREBP genes, we analyzed the duplication patterns of this family in Brassicaceae and identified interacting proteins of representative Arabidopsis AP2/EREBP proteins. We found that many AP2/EREBP duplicates generated early in Brassicaceae history were quickly lost, but many others were retained in all tested Brassicaceae species, suggesting early functional divergence followed by persistent conservation. In addition, the sequences of the AP2 domain and exon numbers were highly conserved in rosids. Furthermore, we used 16 A. thaliana AP2/EREBP proteins as baits in yeast screens and identified 1,970 potential AP2/EREBP‐interacting proteins, with a small subset of interactions verified in planta. Many AP2 genes also exhibit reduced expression in an anther‐defective mutant, providing a possible link to developmental regulation. The putative AP2‐interacting proteins participate in many functions in development and stress responses, including photomorphogenesis, flower development, pathogenesis, drought and cold responses, abscisic acid and auxin signaling. Our results present the AP2/EREBP evolution patterns in Brassicaceae, and support a proposed interaction network of AP2/EREBP proteins and their putative interacting proteins for further study.
Hospital Magnet Status, Unit Work Environment, and Pressure Ulcers
Authors: Ma Chenjuan , Park Shin Hye 
Published: October 2015

AbstractPurposeTo identify how organizational nursing factors at different structural levels (i.e., unit‐level work environment and hospital Magnet status) are associated with hospital‐acquired pressure ulcers (HAPUs) in U.S. acute care hospitals.DesignA cross‐sectional observational study used data from the National Database of Nursing Quality Indicators®. Responses from 33,845 registered nurses (RNs) were used to measure unit work environments. The unit of analysis was the nursing unit, and there were 1,381 units in 373 hospitals in the United States.MethodsUnit work environment was measured by the Practice Environment Scale of Nurse Working Index (PES‐NWI). Multilevel logistic regressions were used to estimate the effects of unit work environment and hospital Magnet status on HAPUs. All models were controlled for hospital and unit characteristics when considering clustering of units within hospitals.ResultsMagnet hospital units had 21% lower odds of having an HAPU than non‐Magnet hospital units (95% confidence interval [CI], 0.64–0.98). With one unit increase of the PES‐NWI score, units had 29% lower odds of having an HAPU (95% CI, 0.55‐0.91). When including both hospital Magnet status and unit work environment in the model, hospital Magnet status no longer had a significant effect on HAPUs (odds ratio [OR] = 0.82; 95% CI, 0.66–1.02), whereas the significant effect of unit work environment persisted (OR = 0.73; 95% CI, 0.56–0.93).ConclusionsBoth hospital and unit environments were significantly associated with HAPUs, and the unit‐level work environment can be more influential in reducing HAPUs.Clinical RelevanceInvestment in the nurse work environments at both the hospital level and unit level has the potential to reduce HAPUs; and additional to hospital‐level initiatives (e.g., Magnet recognition program), efforts targeting on‐unit work environments deserve more attention.
Discontinuities in the endothelium of epiphyseal cartilage canals and relevance to joint disease in foals
Authors: Hellings Ingunn Risnes , Ekman Stina , Hultenby Kjell , Dolvik Nils Ivar , Olstad Kristin 
Published: October 2015

AbstractCartilage canals have been shown to contain discontinuous blood vessels that enable circulating bacteria to bind to cartilage matrix, leading to vascular occlusion and associated pathological changes in pigs and chickens. It is also inconsistently reported that cartilage canals are surrounded by a cellular or acellular wall that may influence whether bacterial binding can occur. It is not known whether equine cartilage canals contain discontinuous endothelium or are surrounded by a wall. This study aimed to examine whether there were discontinuities in the endothelium of cartilage canal vessels, and whether canals had a cellular or acellular wall, in the epiphyseal growth cartilage of foals. Epiphyseal growth cartilage from the proximal third of the medial trochlear ridge of the distal femur from six healthy foals that were 1, 24, 35, 47, 118 and 122 days old and of different breeds and sexes was examined by light microscopy (LM), transmission electron microscopy (TEM) and immunohistochemistry. The majority of patent cartilage canals contained blood vessels that were lined by a thin layer of continuous endothelium. Fenestrations were found in two locations in one venule in a patent cartilage canal located deep in the growth cartilage and close to the ossification front in the 118‐day‐old foal. Chondrifying cartilage canals in allTEM‐examined foals contained degenerated endothelial cells that were detached from the basement membrane, resulting in gap formation. Thirty‐three percent of all canals were surrounded by a hypercellular rim that was interpreted as contribution of chondrocytes to growth cartilage. On LM, 69% of all cartilage canals were surrounded by a ring of matrix that stained intensely eosinophilic and consisted of collagen fibres onTEMthat were confirmed to be collagen type I by immunohistochemistry. In summary, two types of discontinuity were observed in the endothelium of equine epiphyseal cartilage canal vessels: fenestrations were observed in a patent cartilage canal in the 118‐day‐old foal; and gaps were observed in chondrifying cartilage canals in allTEM‐examined foals. Canals were not surrounded by any cellular wall, but a large proportion was surrounded by an acellular wall consisting of collagen type I. Bacterial binding can therefore probably occur in horses by mechanisms that are similar to those previously demonstrated in pigs and chickens.
Marriage Advantages in Perinatal Health: Evidence of Marriage Selection or Marriage Protection?
Authors: Kane Jennifer B. 
Published: October 2015

AbstractMarriage is a social tie associated with health advantages for adults and their children, as lower rates of preterm birth and low birth weight are observed among married women. In this study the author tested 2 competing hypotheses explaining this marriage advantage—marriage protection versus marriage selection—using a sample of recent births to single, cohabiting, and married women from the National Survey of Family Growth, 2006–2010. Propensity score matching and fixed effects regression results demonstrated support for marriage selection, as a rich set of early life selection factors account for all of the cohabiting–married disparity and part of the single–married disparity. Subsequent analyses demonstrated that prenatal smoking mediates the adjusted single–married disparity in birth weight, lending some support for the marriage protection perspective. The study's findings sharpen our understanding of why and how marriage matters for child well‐being and provide insight into pre‐conception and prenatal factors describing intergenerational transmissions of inequality via birth weight.
Assessment of mitral regurgitation in dogs: comparison of results of echocardiography with magnetic resonance imaging
Authors: Sargent J. , Connolly D. J. , Watts V. , Mõtsküla P. , Volk H. A. , Lamb C. R. , Luis Fuentes V. 
Published: October 2015

AbstractOBJECTIVESEchocardiography is used routinely to assess mitral regurgitation severity, but echocardiographic measures of mitral regurgitation in dogs have not been compared with other quantitative methods. The study aim was to compare echocardiographic measures of mitral regurgitation with cardiac magnetic resonance imaging‐derived mitral regurgitant fraction in small‐breed dogs.METHODSDogs with myxomatous mitral valve disease scheduled for magnetic resonance imaging assessment of neurological disease were recruited. Correlations were tested between cardiac magnetic resonance imaging‐derived mitral regurgitant fraction and the following echocardiographic measures: vena contracta/aortic diameter, transmitral E‐wave velocity, amplitude of mitral prolapse/aortic diameter, diastolic left ventricular diameter:aortic diameter, left atrium:aortic diameter, mitral regurgitation jet area ratio and regurgitant fraction calculated using the proximal isovelocity surface area method.RESULTSMeasurement of cardiac magnetic resonance imaging‐derived mitral regurgitant fraction was attempted in 21 dogs. Twelve consecutive, complete studies were obtained and 10 dogs were included in the final analysis: vena contracta/aortic diameter (r = 0 · 89, p = 0 · 001) and E‐wave velocity (r = 0 · 86, p = 0 · 001) had the strongest correlations with cardiac magnetic resonance imaging‐derived mitral regurgitant fraction. E velocity had superior repeatability and could be measured in all dogs. The presence of multiple jets precluded vena contracta/aortic diameter measurement in one dog.CLINICAL SIGNIFICANCEMeasurement of cardiac magnetic resonance imaging‐derived mitral regurgitant fraction is feasible but technically demanding. The echocardiographic measures that correlated most closely with cardiac magnetic resonance imaging‐derived mitral regurgitant fraction were vena contracta/aortic diameter and E‐wave velocity.
Displaced and forgotten child refugees: A humanitarian crisis
Authors: Murray John S. 
Published: October 2015

AbstractPurposeTo describe where child refugees are located, the risks they face, leading health problems, and how pediatric healthcare professionals can help.ConclusionsChildren constitute approximately 46% of refugees worldwide. These refugees fled their home countries due to conflict and persecution, and cannot return because of race, religion, nationality, political opinion, or membership in a particular social group.Practice ImplicationsPediatric nurses have an unprecedented opportunity to advocate for child refugees by contributing to the international conversation on the human rights of immigrants.
Predicting Outcome in dogs with Primary Immune‐Mediated Hemolytic Anemia: Results of a Multicenter Case Registry
Authors: Goggs R. , Dennis S.G. , Di Bella A. , Humm K.R. , McLauchlan G. , Mooney C. , Ridyard A. , Tappin S. , Walker D. , Warman S. , Whitley N.T. , Brodbelt D.C. , Chan D.L. 
Published: October 2015

BackgroundOutcome prediction in dogs with immune‐mediated hemolytic anemia (IMHA) is challenging and few prognostic indicators have been consistently identified.ObjectivesAn online case registry was initiated to: prospectively survey canine IMHA presentation and management in the British Isles; evaluate 2 previously reported illness severity scores, Canine Hemolytic Anemia Score (CHAOS) and Tokyo and to identify independent prognostic markers.AnimalsData from 276 dogs with primary IMHA across 10 referral centers were collected between 2008 and 2012.MethodsOutcome prediction by previously reported illness‐severity scores was tested using univariate logistic regression. Independent predictors of death in hospital or by 30‐days after admission were identified using multivariable logistic regression.ResultsPurebreds represented 89.1% dogs (n = 246). Immunosuppressive medications were administered to 88.4% dogs (n = 244), 76.1% (n = 210) received antithrombotics and 74.3% (n = 205) received packed red blood cells. Seventy‐four per cent of dogs (n = 205) were discharged from hospital and 67.7% (n = 187) were alive 30‐days after admission. Two dogs were lost to follow‐up at 30‐days. In univariate analyses CHAOS was associated with death in hospital and death within 30‐days. Tokyo score was not associated with either outcome measure. A model containing SIRS‐classification, ASA classification, ALT, bilirubin, urea and creatinine predicting outcome at discharge was accurate in 82% of cases. ASA classification, bilirubin, urea and creatinine were independently associated with death in hospital or by 30‐days.Conclusions and clinical importanceMarkers of kidney function, bilirubin concentration and ASA classification are independently associated with outcome in dogs with IMHA. Validation of this score in an unrelated population is now warranted.