bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metoclopramide or domperidone improves post-pyloric placement of spiral nasojejunal tubes in critically ill patients: a prospective, multicenter, open-label, randomized, controlled clinical trial
Authors: Hu Bei , Ye Heng , Sun Cheng , Zhang Yichen , Lao Zhigang , Wu Fanghong , Liu Zhaohui , Huang Linxi , Qu Changchun , Xian Lewu , Wu Hao , Jiao Yingjie , Liu Junling , Cai Juyu , Chen Weiying , Nie Zhiqiang , Liu Zaiyi , Chen Chunbo 
Published: February 2015

Abstract
Introduction
The use of prokinetic agents on post-pyloric placement of spiral nasojejunal tubes is controversial. The aim of the present study was to examine if metoclopramide or domperidone can increase the success rate of post-pyloric placement of spiral nasojejunal tubes.

Methods
A multicenter, open-label, randomized, controlled trial was conducted in seven hospitals in China between April 2012 and February 2014. Patients admitted to the intensive care unit and requiring enteral nutrition for more than three days were randomly assigned to the metoclopramide, domperidone or control groups (1:1:1 ratio). The primary outcome was defined as the success rate of post-pyloric placement of spiral nasojejunal tubes, assessed 24 hours after initial placement. Secondary outcomes included success rate of post-D1, post-D2, post-D3 and proximal jejunum placement and tube migration distance. Safety of the study drugs and the tubes during the entire study period were recorded.

Results
In total, 307 patients were allocated to the metoclopramide (n = 103), domperidone (n = 100) or control group (n = 104). The success rate of post-pyloric placement after 24 hours in the metoclopramide, domperidone and control groups was 55.0%, 51.5% and 27.3%, respectively (P = 0.0001). Logistic regression analysis identified the use of prokinetic agents, Acute Physiology and Chronic Health Evaluation (APACHE) II score <20, Sequential Organ Failure Assessment (SOFA) score <12 and without vasopressor as independent factors influencing the success rate of post-pyloric placement. No serious drug-related adverse reaction was observed.

Conclusions
Prokinetic agents, such as metoclopramide or domperidone, are effective at improving the success rate of post-pyloric placement of spiral nasojejunal tubes in critically ill patients.

Trial registration
Chinese Clinical Trial Registry ChiCTR-TRC-12001956. Registered 21 February 2012.
Set-valued G-Prešić operators on metric spaces endowed with a graph and fixed point theorems
Authors: Shahzad Naseer , Shukla Satish 
Published: February 2015

AbstractIn this paper, we consider the set-valued contractions defined on product spaces when the underlying space is a complete metric space endowed with a graph. Some fixed point results for the so-called set-valued G-Prešić operators are established. Our theorems extend and generalize some known results in product spaces of the recent literature. As an application of our main result, fixed point results for various types of set-valued contractions on product spaces are derived, and a sufficient condition for the existence of a weakly asymptotically stable and global attractor equilibrium point of a kth order nonlinear difference inclusion is established.
A new iterative algorithm for the sum of two different types of finitely many accretive operators in Banach space and its connection with capillarity equation
Authors: Wei Li , Duan Liling 
Published: February 2015

AbstractIn this paper, we present a new iterative algorithm with errors to solve the problems of finding zeros of the sum of finitely many m-accretive operators and finitely many α-inversely strongly accretive operators in a real smooth and uniformly convex Banach space. Strong convergence theorems are established, which extend the corresponding works given by some authors. Moreover, the relationship among the zero of the sum of m-accretive operator and α-inversely strongly accretive operator, the solution of one kind variational inequality, and the solution of the capillarity equation is investigated.
High throughput molecular dynamics for drug discovery
Authors: Stanley Nathaniel , De Fabritiis Gianni 
Published: February 2015

AbstractMolecular dynamics simulations hold the promise to be an important tool for biological research and drug discovery. Historically, however, there were several obstacles for it to become a practical research tool. Limitations in computer hardware had previously made it difficult to simulate for long enough to see interesting biological processes. Recent improvements in hardware and algorithms have largely removed this issue, leaving data analysis as the main obstacle. Advances in Markov state modeling appear to be on the way to remove this obstacle. We outline these advances here and discuss numerous recent studies that demonstrate that molecular dynamics simulations will start to be an important tool for pharmaceutical research.
Ectosomes from neutrophil-like cells down-regulate nickel-induced dendritic cell maturation and promote Th2 polarization
Authors: Turbica Isabelle , Gallais Yann , Gueguen Claire , Tharinger Hugo , Al Sabbagh Chantal , Gorges Roseline , Gary-Gouy He´le`ne , Kerdine-Ro¨mer Saadia , Pallardy Marc , Mascarell Laurent , Gleizes Aude , Chollet-Martin Sylvie 
Published: February 2015

Abstract
DCs are the first immune cells to be exposed to allergens, including chemical sensitizers, such as nickel, a human TLR4 agonist that induces DC maturation. In ACD, DCs can interact with PMNs that are recruited and activated, leading, in particular, to ectosome release. The objective of this work was to characterize the effects of PMN-Ect on DC functions in an ACD context. We first developed a standardized protocol to produce, characterize, and quantify ectosomes by use of human PLB-985 cells, differentiated into mature PMN (PLB-Ect). We then studied the in vitro effects of these purified ectosomes on human moDC functions in response to NiSO4 and to LPS, another TLR4 agonist. Confocal fluorescence microscopy showed that PLB-Ect was internalized by moDCs and localized in the lysosomal compartment. We then showed that PLB-Ect down-regulated NiSO4-induced moDC maturation, as witnessed by decreased expression of CD40, CD80, CD83, CD86, PDL-1, and HLA-DR and by decreased levels of IL-1β, IL-6, TNF-α, and IL-12p40 mRNAs. These effects were related to p38MAPK and NF-κB down-regulation. However, no increase in pan-regulatory DC marker genes (GILZ, CATC, C1QA) was observed; rather, levels of effector DC markers (Mx1, NMES1) were increased. Finally, when these PLB-Ect + NiSO4-treated moDCs were cocultured with CD4+ T cells, a Th2 cytokine profile seemed to be induced, as shown, in particular, by enhanced IL-13 production. Together, these results suggest that the PMN-Ect can modulate DC maturation in response to nickel, a common chemical sensitizer responsible for ADC.
Impaired maturation of large dense-core vesicles in muted-deficient adrenal chromaffin cells
Authors: Hao Zhenhua , Wei Lisi , Feng Yaqin , Chen Xiaowei , Du Wen , Ma Jing , Zhou Zhuan , Chen Liangyi , Li Wei 
Published: February 2015

ABSTRACT
The large dense-core vesicle (LDCV), a type of lysosome-related organelle, is involved in the secretion of hormones and neuropeptides in specialized secretory cells. The granin family is a driving force in LDCV biogenesis, but the machinery for granin sorting to this biogenesis pathway is largely unknown. The mu mutant mouse, which carries a spontaneous null mutation on the Muted gene (also known as Bloc1s5), which encodes a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), is a mouse model of Hermansky–Pudlak syndrome. Here, we found that LDCVs were enlarged in mu adrenal chromaffin cells. Chromogranin A (CgA, also known as CHGA) was increased in mu adrenals and muted-knockdown cells. The increased CgA in mu mice was likely due a failure to export this molecule out of immature LDCVs, which impairs LDCV maturation and docking. In mu chromaffin cells, the size of readily releasable pool and the vesicle release frequency were reduced. Our studies suggest that the muted protein is involved in the selective export of CgA during the biogenesis of LDCVs.
The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting
Authors: Wang Jing , Deretic Dusanka 
Published: February 2015

ABSTRACT
Primary cilia have gained considerable importance in biology and disease now that their involvement in a wide range of human ciliopathies has been abundantly documented. However, detailed molecular mechanisms for specific targeting of sensory receptors to primary cilia are still unknown. Here, we show that the Arf and Rab11 effector FIP3 (also known as RAB11FIP3) promotes the activity of Rab11a and the Arf GTPase-activating protein (GAP) ASAP1 in the Arf4-dependent ciliary transport of the sensory receptor rhodopsin. During its passage out of the photoreceptor Golgi and trans-Golgi network (TGN), rhodopsin indirectly interacts with FIP3 through Rab11a and ASAP1. FIP3 competes with rhodopsin for binding to ASAP1 and displaces it from the ternary complex with Arf4–GTP and ASAP1. Resembling the phenotype resulting from &lt;/emph&gt;lack of ASAP1, ablation of FIP3 abolishes ciliary targeting and causes rhodopsin mislocalization. FIP3 coordinates the interactions of ASAP1 and Rab11a with the Rab8 guanine nucleotide exchange factor Rabin8 (also known as RAB3IP). Our study implies that FIP3 functions as a crucial targeting regulator, which impinges on rhodopsin–ASAP1 interactions and shapes the binding pocket for Rabin8 within the ASAP1–Rab11a–FIP3 targeting complex, thus facilitating the orderly assembly and activation of the Rab11–Rabin8–Rab8 cascade during ciliary receptor trafficking.
The femoral head–neck contour varies as a function of physeal development
Authors: Vo A. , Beaule P. E. , Sampaio M. L. , Rotaru C. , Rakhra K. S. 
Published: February 2015

ObjectivesThe purpose of this study was to investigate whether the femoral head–neck contour, characterised by the alpha angle, varies with the stage of physeal maturation using MRI evaluation of an asymptomatic paediatric population.MethodsPaediatric volunteers with asymptomatic hips were recruited to undergo MRI of both hips. Femoral head physes were graded from 1 (completely open) to 6 (completely fused). The femoral head–neck contour was evaluated using the alpha angle, measured at the 3:00 (anterior) and 1:30 (anterosuperior) positions and correlated with physeal grade, with gender sub-analysis performed.ResultsA total of 43 asymptomatic paediatric volunteers (26 male, 17 female) with mean age 13.0 years (eight to 18) were included with review of bilateral hip MRIs. Correlation between the physeal grade and alpha angle was moderate in males at both the 3:00 (r = 0.477, p < 0.001) and 1:30 (r = 0.509, p < 0.001) positions, whereas there was no significant correlation in females. A significant difference was found between the alpha angles of all the physeal grades (3:00, p = 0.030, 1:30, p = 0.005), but only in males, with the angle increasing with higher grades. For physeal grading, the inter-reader reliability was substantial (intraclass correlation coefficient (ICC) = 0.694), and the intra-reader reliability was also substantial (ICC = 0.788).ConclusionThe femoral head–neck contour varies and correlates with the stage of physeal development, but only in males, with the alpha angle increasing with progressive physeal maturation. This suggests that gender differences exist in the natural physiological growth, development or remodelling of femoral head–neck junction. In males, pre-physeal fusion may be a critical period of vulnerability for development of morphologic abnormalities of the femoral head–neck junction. Cite this article: Bone Joint Res 2015;4:17–22
The function of narrative in public space: Witnessing performed storytelling in Northern Ireland
Authors: Weiglhofer Magdalena 
Published: February 2015

Abstract
In an examination of how witnessing autobiographical stories through a performance onstage affects audiences, this article considers the function of narrative in public space. Its key focus lies on exploring the concept of witnessing through an analysis of the audience’s reception of two autobiographical storytelling performances in Northern Ireland. Drawing on the affirmative response to the portrayal of suffering, the argument is developed that, in today’s ‘therapeutic culture’, people are used to, prepared and therefore keen to hear from personal experiences and emotions but are, at the same time, yearning to return to ‘real’ emotions in an environment of emotional commodification.
Starting from scratch: Forming a community of practice in an Australian late starters’ wind
Authors: Southcott Jane 
Published: February 2015

Abstract
Musical participation is a powerful form of community engagement, offering agency in positive ageing. Community music endeavours usually involve active music-making and acquisition of musical skills and understandings. Participants in such programmes elect to become involved, often taking responsibility for the survival of the group. This case study explores the understandings of members of a community band, the Second Wind Ensemble, formed in 1998 in Adelaide, South Australia. Initially, the band offered late starters the opportunity to learn an instrument. The ensemble now has approximately 60 players with a regular programme of concerts, rehearsals, tutorials and social gatherings. The band conductor is a professional music educator. This study chronicles the development of a community of practice with the band members gradually assuming responsibility for their ensemble. This discussion considers only the first two years in the history of the ensemble, during which time the roles of participants evolved. In this case study, the founder, conductor, organizer and a number of participants were interviewed and data analysed using Interpretative Phenomenological Analysis (IPA). The themes identified from these multiple perspectives focus on well-being, active engagement with community, the development of musical skills and understandings, and the formation of a community of practice.
Conference Reviews
Authors: Cordileone Amy , Low Katharine E. 
Published: February 2015

Abstract
Forum on the Teaching Artist: Navigation, Innovation, and Sustainability, New York University, Steinhardt School of Culture, Education, and Human Development Program in Educational Theatre, 25–27 April 2014
Conference Review of the TaPRA Applied and Social Theatre Working Group’s Interim Event on Heroism and the Heroic in Applied and Social Theatre, Royal Central School of Speech and Drama, London, 22 March 2014
The study of the political economy of the media in the twenty-first century
Authors: Wasko Janet 
Published: February 2015

Abstract
This discussion presents a brief overview of the establishment and expansion of the study of the political economy of media and communications, followed by attention to some of current directions of this approach. Themes and concepts developed by political economists of the media are reviewed, as well as internal and external critiques of the approach. Recent developments are discussed, including the growth of integrated studies, the return to classic Marxist themes, integration of digital technologies, and attention to policy and activism.
Nonsolvability of the asymptotic Dirichlet problem for the p-Laplacian on Cartan–Hadamard manifolds
Authors: Holopainen Ilkka 
Published: February 2015

Abstract
We construct, by modifying Borbély's example, a 3-dimensional Cartan–Hadamard manifold M, with
sectional curvatures at most -1, such that the asymptotic Dirichlet problem for the p-Laplacian is not
solvable for any p > 1.
Uniform Estimate for Randomly Weighted Sums of Dependent Subexponential Random Variables
Authors: Liu Yan , Zhang Qinqin 
Published: February 2015

Abstract
This paper obtains the uniform tail asymptotics of the maximum of randomly weighted sum

max

1
≤
k
≤
n

∑

i
=
1

k

θ
i

X
i

$$\mathop {\max}\limits_{1 \le k \le n} \sum\nolimits_{i = 1}^k {\theta _i}{X_i}$$

with respective to n, in which the primary random variables

X
1

,
.
.
.
,

X
n

$${X_1},...,{X_n}$$

are real valued, dependent, and have different subexponential distributions, while the random weights

θ
1

,
.
.
.
,

θ
n

$${\theta _1},...,{\theta _n}$$

are nonnegative and arbitrarily dependent, but independent of

X
1

,
.
.
.
,

X
n

$${X_1},...,{X_n}$$

. An application to insurance risk model with investment portfolio is proposed.
Obesity and cancer
Authors: Ungefroren Hendrik , Gieseler Frank , Fliedner Stephanie , Lehnert Hendrik 
Published: February 2015

Abstract
The incidence of obesity in the Western world has increased dramatically during the recent decades. Epidemiological data suggest that obesity is associated with an increased risk of several but not all types of cancers, with clear sex-specific differences. The underlying mechanisms are still a matter of debate. In this review, we discuss the potential factors linking obesity to cancer, with a focus on hormone-dependent cancer types. Current experimental evidence suggests that insulin resistance and a chronic, subclinical inflammation in the visceral fat are the major metabolic events, causing alterations in the levels of insulin, glucose, free fatty acids, insulin-like growth factor-1 and -2, adipose tissue-derived proinflammatory factors (tumor necrosis factor-α and interleukin-1, -6, -12, and -23), and other bioactive molecules such as adipokines (adiponectin and leptin), vascular endothelial growth factor, sex hormones, gut microbiota, and secondary bile acids. All these factors may act directly or indirectly on the tumor microenvironment to drive tumor progression via the stimulation of cell survival/antiapoptosis, cell proliferation, angiogenesis, and invasion/metastasis of cancer cells. Therapeutic strategies (including bariatric surgery) that target dysfunctional or inflamed fat have been shown to benefit patients, whereas other cell- or hormone-directed interventions (such as the conversion of visceral fat macrophages to an anti-inflammatory M2 phenotype or the pharmacological modulation of serum adipokine levels) are still theoretical and need to be clinically evaluated for their ability to successfully treat or prevent obesity-related cancers.
Crystal structure of (E)-2-[(ortho-hydroxy)benzylidene]-2-(thiomethyl)- thionohydrazide, C9H10N2OS2
Authors: Madanhire Tatenda , Abrahams Abubak'r , Hosten Eric C. , Betz Richard 
Published: February 2015

Abstract C9H10N2OS2, monoclinic, P21/n (no. 14), a = 4.0727(2) Å, b = 22.256(1) Å, c = 11.4854(6) Å, β = 98.364(3)°, V = 1030.0 Å3, Z = 4, Rgt(F) = 0.0295, wRref(F2) = 0.0725, T = 200 K.
Crystal structure of chlorido-(1,3-dimesitylimidazolidin-2-ylidene-κ1C)- gold(I), C21H26AuClN2
Authors: Huang Yao-Huei , Lee Hon Man 
Published: February 2015

Abstract C21H26AuClN2, orthorhombic, Pbca (no. 61), a = 8.7507(1) Å, b = 15.8341(2) Å, c = 29.9642(4) Å, V = 4151.8 Å3, Z = 8, Rgt(F) = 0.0204, wRref(F2) = 0.0403, T = 150 K.
Scattering State of Coupled Hulthen–Woods–Saxon Potentials for the Duffin–Kemmer–Petiau Equation with Pekeris Approximation for the Centrifugal Term
Authors: Ikot Akpan N. , Obong Hillary P. , Olisa Joy D. , Hassanabadi Hassan 
Published: February 2015

Abstract
We studied the approximate analytical scattering state of the Duffin–Kemmer–Petiau (DKP) equation for arbitrary l-state for couple Hulthen–Woods–Saxon potential using the Pekeris approximation for the centrifugal term. We obtained an energy spectrum, normalised radial wave functions of the scattering states, and the corresponding formula for the phase shifts, which is derived in detail. Special cases of Hulthen and Woods–Saxon potentials were also studied.
Compartment‐specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition
Authors: Miller Stephanie BM , Ho Chi‐Ting , Winkler Juliane , Khokhrina Maria , Neuner Annett , Mohamed Mohamed YH , Guilbride D Lys , Richter Karsten , Lisby Michael , Schiebel Elmar , Mogk Axel , Bukau Bernd 
Published: February 2015

AbstractDisruption of the functional protein balance in living cells activates protective quality control systems to repair damaged proteins or sequester potentially cytotoxic misfolded proteins into aggregates. The established model based on Saccharomyces cerevisiae indicates that aggregating proteins in the cytosol of eukaryotic cells partition between cytosolic juxtanuclear (JUNQ) and peripheral deposits. Substrate ubiquitination acts as the sorting principle determining JUNQ deposition and subsequent degradation. Here, we show that JUNQ unexpectedly resides inside the nucleus, defining a new intranuclear quality control compartment, INQ, for the deposition of both nuclear and cytosolic misfolded proteins, irrespective of ubiquitination. Deposition of misfolded cytosolic proteins at INQ involves chaperone‐assisted nuclear import via nuclear pores. The compartment‐specific aggregases, Btn2 (nuclear) and Hsp42 (cytosolic), direct protein deposition to nuclear INQ and cytosolic (CytoQ) sites, respectively. Intriguingly, Btn2 is transiently induced by both protein folding stress and DNA replication stress, with DNA surveillance proteins accumulating at INQ. Our data therefore reveal a bipartite, inter‐compartmental protein quality control system linked to DNA surveillance via INQ and Btn2.
Power Analysis of Artificial Selection Experiments Using Efficient Whole Genome Simulation of Quantitative Traits
Authors: Kessner Darren , Novembre John 
Published: February 2015

Abstract
Evolve and resequence studies combine artificial selection experiments with massively parallel sequencing technology to study the genetic basis for complex traits. In these experiments, individuals are selected for extreme values of a trait, causing alleles at quantitative trait loci (QTL) to increase or decrease in frequency in the experimental population. We present a new analysis of the power of artificial selection experiments to detect and localize quantitative trait loci. This analysis uses a simulation framework that explicitly models whole genomes of individuals, quantitative traits, and selection based on individual trait values. We find that explicitly modeling QTL provides qualitatively different insights than considering independent loci with constant selection coefficients. Specifically, we observe how interference between QTL under selection affects the trajectories and lengthens the fixation times of selected alleles. We also show that a substantial portion of the genetic variance of the trait (50–100%) can be explained by detected QTL in as little as 20 generations of selection, depending on the trait architecture and experimental design. Furthermore, we show that power depends crucially on the opportunity for recombination during the experiment. Finally, we show that an increase in power is obtained by leveraging founder haplotype information to obtain allele frequency estimates.
Fabrication and Lasing Properties of Single-Crystalline Semiconductor Microspheres with Anisotropic Crystal Structures
Authors: Okamoto Shinya , Ichikawa Satoshi , Minowa Yosuke , Ashida Masaaki 
Published: February 2015

ABSTRACTWe fabricated single-crystalline microspheres of wide-gap semiconductors with anisotropic crystal structures, such as ZnO and ZnSe, by laser ablation in superfluid helium and investigated their lasing properties. Whispering gallery mode lasing at their band edges in ultraviolet region was clearly observed under the optical excitation, reflecting their high sphericity and crystal quality.