bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of unilateral conductive hearing loss due to aural atresia on academic performance in children
Authors: Kesser Bradley W. , Krook Kaelyn , Gray Lincoln C. 
Published: March 2013

Objectives/HypothesisThis study evaluates the effect of unilateral conductive hearing loss secondary to aural atresia on elementary school children's academic performance.Study DesignCase control survey and review of audiometric data.MethodsOne hundred thirty‐two surveys were mailed to families of children with aural atresia, and 48 surveys were sent to families of children with unilateral sensorineural hearing loss (SNHL) to identify rates of grade retention, use of any resource, and behavioral problems. Audiometric data of the cohort were tabulated.ResultsOf the 40 atresia patients, none repeated a grade, but 65% needed some resources: 12.5% currently use a hearing aid, 32.5% use(d) a frequency‐modulated system in school, 47.5% had an Individualized Education Plan, and 45% utilized speech therapy. Compared to the unilateral SNHL group and a cohort of children with unilateral SNHL in an earlier study,1 children with unilateral atresia were less likely to repeat a grade. Children in both unilateral atresia and SNHL groups were more likely to utilize some resource in the academic setting compared to the unilateral SNHL children in the prior study.ConclusionsUnilateral conductive hearing loss due to aural atresia has an impact on academic performance in children, although not as profound when compared to children with unilateral SNHL. The majority of these children with unilateral atresia utilize resources in the school setting. Parents, educators, and health care professionals should be aware of the impact of unilateral conductive hearing loss and offer appropriate habilitative services.Level of Evidence3b. Laryngoscope, 123:2270–2275, 2013
Access to Different Nanostructures via Self‐Assembly of Thiourea‐Containing PEGylated Amphiphiles
Authors: Venkataraman Shrinivas , Chowdhury Zarir Ashraf , Lee Ashlynn L. , Tong Yen Wah , Akiba Isamu , Yang Yi Yan 
Published: March 2013

AbstractReadily water‐soluble PEGylated amphiphiles containing bis‐thiourea‐based molecular recognition units at the interface of hydrophobic and hydrophilic blocks are developed. Self‐assembly of these amphiphiles is found to be dependent on the exact chemical composition of the hydrophobic component. Elongated, spherical, and disk‐like micelles are formed with the change in hydrophobic group from stearyl (2A), oleyl (2B), and dodecanol (2C), respectively. The length of the rod‐like elongated micelles formed by 2A could be tuned by thermal treatment as well. Synthesis and detailed structural characterization of these amphiphiles by TEM, DSC, synchrotron SAXS techniques are reported. Organic solvent‐free direct aqueous encapsulation of doxorubicin, an anticancer drug into these nanostructures is demonstrated.magnified image
Managerial Delegation Contracts under Centralized Unionization
Authors: Meccheri Nicola , Fanti Luciano 
Published: March 2013

AbstractThis paper studies how alternative managerial delegation contracts in a duopoly product market interact with wage decisions taken by a central (industry‐wide) union in the labor market. Interestingly, results prove to be more varied with respect to findings by the managerial delegation literature with exogenous production costs. Most notably, it is pointed out that, in equilibrium, both firm profitability and welfare outcomes can be superior under both sales delegation and relative profit delegation, depending on various factors such as the degree of product differentiation and the competition regime. Copyright © 2013 John Wiley & Sons, Ltd.
Validation of parkinsonian disease‐related metabolic brain patterns
Authors: Teune Laura K. , Renken Remco J. , Mudali Deborah , De Jong Bauke M. , Dierckx Rudi A. , Roerdink Jos B.T.M. , Leenders Klaus L. 
Published: March 2013

ABSTRACTBackgroundThe objective of this study was to validate disease‐related metabolic brain patterns for Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.MethodsThe study included 20 patients with Parkinson's disease, 21 with multiple system atrophy, and 17 with progressive supranuclear palsy, all of whom had undergone a clinically motivated [18F]‐fluoro‐deoxyglucose positron emission tomography scan at an early stage of their disease. At a follow‐up time after the scan of 2–4 years, a clinical diagnosis was made according to established clinical research criteria. Patient groups were compared with 18 healthy controls using a multivariate covariance image analysis technique called scaled subprofile model/principal component analysis.ResultsDisease‐related metabolic brain patterns for these parkinsonian disorders were identified. Validation showed that these patterns were highly discriminative of the 3 disorders.ConclusionsEarly diagnosis of parkinsonian disorders is feasible when the expression of disease‐related metabolic brain patterns is quantified at a single‐subject level. © 2013 Movement Disorder Society
The inferior olivary nucleus: A postmortem study of essential tremor cases versus controls
Authors: Louis Elan D. , Babij Rachel , Cortés Etty , Vonsattel Jean‐Paul G. , Faust Phyllis L. 
Published: March 2013

ABSTRACTThe pathogenesis of essential tremor is poorly understood. Historically, it has been hypothesized that the inferior olivary nucleus plays an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic‐pathological study of that brain region has yet to be conducted. A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases versus 15 age‐matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density also was assessed. Cases and controls did not differ from one another with respect to any of the assessed metrics (P values ranged from 0.23 to 1.0). Olivary linear neuronal density also was similar in cases and controls (P = 0.62). Paddle‐shaped neurons, a morphologic shape change in olivary neurons, which, to our knowledge, have not been previously recognized, occurred to an equal degree in essential tremor cases and controls (P = 0.89) and were correlated with several markers of neuronal loss and gliosis. A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that, if the olive is involved in essential tremor, then there is no clearly identifiable structural or metabolic correlate. © 2013 Movement Disorder Society
Computational Investigation of SENP:SUMO Protein‐Protein Interaction for Structure Based Drug Design
Authors: Kumar Ashutosh , Zhang Kam Y. J. 
Published: March 2013

AbstractSUMO specific proteases (SENPs) are cysteine proteases that carry out the proteolytic processing of SUMO from its pro form as well as its deconjugation from substrate proteins. SENPs have been implicated in various cancers including prostate cancer, thyroid cancer and colon cancer. Therefore, the inhibition of SENPs is an attractive strategy for the treatment of cancer. However, the current SENP inhibitor development strategies target catalytic site and involve the usage of reactive functionalities to facilitate the covalent binding with a catalytic cysteine, which makes them less desirable for therapeutic purposes. Based on the available structural knowledge about the interaction of SENPs with various SUMO paralogues, an alternative approach for inhibiting SENPs could be via targeting SENP:SUMO protein‐protein interaction. Here we have investigated the protein‐protein interaction between SENP and SUMO as a target for structure based drug design using pocket prediction, ligand binding hotspot mapping, molecular dynamics simulation and in silico alanine mutagenesis. Finally, we have provided recommendations for the structure based design of SENP:SUMO protein‐protein interaction inhibitors. Our study indicates that the SENP inhibitors targeting SENP:SUMO protein‐protein interaction is a viable alternative strategy to existing inhibitors targeting the enzymatic site.
Festkörperchemie 2012
Authors: Adelhelm Philipp , Armbrüster Marc , Kraus Florian 
Published: March 2013

AbstractSpannendes von den Elementen, neue Verbindungen mit überraschenden Bausteinen und Eigenschaften sowie die Lösung einiger “100‐jähriger Fragen” — die Festkörperchemie präsentiert sich in Bestform.
Lebensmittelchemie 2012
Authors: Berger Ralf G. , Schrader Jens , Schwab Wilfried , Wüst Matthias , Zorn Holger 
Published: March 2013

AbstractNeben der Identifizierung von Aromastoffen durch die molekulare Sensorik sind die Aufklärung ihrer Biosynthese sowie ihre biotechnische Produktion ins Zentrum der Aromastoffforschung gerückt.
Qualitative and Quantitative Analysis of Phenolic Compounds in the Leaves of Aquilaria sinensis Using Liquid Chromatography–Mass Spectrometry
Authors: Yu Qian , Qi Jin , Yu Hai‐Xiang , Chen Lin‐Lin , Kou Jun‐Ping , Liu Shou‐Jin , Yu Bo‐Yang 
Published: March 2013

ABSTRACTIntroductionThe leaves of Aquilaria sinensis traditionally have been used in China for a century. Phenolic compounds were investigated to be the major active compounds in them.ObjectiveTo establish a method that will simultaneously determine the phenolic compounds in Aquilaria sinensis leaves and identify their characteristic fragmentation patterns, and to make a comparison of A. sinensis leaf samples from different areas of China.MethodsHigh‐performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) and photodiode array detection (DAD) were used for the qualitative and quantitative analysis.ResultsTwenty‐one compounds, including xanthones, benzophenones and flavones, were identified or tentatively characterised. The fragmentation patterns of xanthones and benzophenones were also described. Also, eight components in the herbal samples from different regions were determined by HPLC‐DAD.ConclusionThe method developed is suitable for the qualitative and quantitative analysis of phenolic constituents in the leaves of A. sinensis. Copyright © 2013 John Wiley & Sons, Ltd.
Interval Multivariate Curve Resolution in the Dereplication of HPLC–DAD Data from Jatropha gossypifolia
Authors: Pilon Alan Cesar , Carneiro R. L. , Carnevale Neto F. , da S. Bolzani Vanderlan , Castro‐Gamboa I. 
Published: March 2013

ABSTRACTIntroductionJatropha gossypifolia has been used quite extensively by traditional medicine for the treatment of several diseases in South America and Africa. This medicinal plant has therapeutic potential as a phytomedicine and therefore the establishment of innovative analytical methods to characterise their active components is crucial to the future development of a quality product.ObjectiveTo enhance the chromatographic resolution of HPLC–UV–diode‐array detector (DAD) experiments applying chemometric tools.MethodsCrude leave extracts from J. gossypifolia were analysed by HPLC–DAD. A chromatographic band deconvolution method was designed and applied using interval multivariate curve resolution by alternating least squares (MCR–ALS).ResultsThe MCR–ALS method allowed the deconvolution from up to 117% more bands, compared with the original HPLC–DAD experiments, even in regions where the UV spectra showed high similarity. The method assisted in the dereplication of three C‐glycosylflavones isomers: vitexin/isovitexin, orientin/homorientin and schaftoside/isoschaftoside.ConclusionThe MCR–ALS method is shown to be a powerful tool to solve problems of chromatographic band overlapping from complex mixtures such as natural crude samples. Copyright © 2013 John Wiley & Sons, Ltd.
A Modern Approach to the Authentication and Quality Assessment of Thyme Using UV Spectroscopy and Chemometric Analysis
Authors: Gad Haidy A. , El‐Ahmady Sherweit H. , Abou‐Shoer Mohamed I. , Al‐Azizi Mohamed M. 
Published: March 2013

ABSTRACTIntroductionRecently, the fields of chemometrics and multivariate analysis have been widely implemented in the quality control of herbal drugs to produce precise results, which is crucial in the field of medicine. Thyme represents an essential medicinal herb that is constantly adulterated due to its resemblance to many other plants with similar organoleptic properties.ObjectiveTo establish a simple model for the quality assessment of Thymus species using UV spectroscopy together with known chemometric techniques. The success of this model may also serve as a technique for the quality control of other herbal drugs.Materials and methodsThe model was constructed using 30 samples of authenticated Thymus vulgaris and challenged with 20 samples of different botanical origins. The methanolic extracts of all samples were assessed using UV spectroscopy together with chemometric techniques: principal component analysis (PCA), soft independent modeling of class analogy (SIMCA) and hierarchical cluster analysis (HCA).ResultsThe model was able to discriminate T. vulgaris from other Thymus, Satureja, Origanum, Plectranthus and Eriocephalus species, all traded in the Egyptian market as different types of thyme. The model was also able to classify closely related species in clusters using PCA and HCA. The model was finally used to classify 12 commercial thyme varieties into clusters of species incorporated in the model as thyme or non‐thyme.ConclusionThe model constructed is highly recommended as a simple and efficient method for distinguishing T. vulgaris from other related species as well as the classification of marketed herbs as thyme or non‐thyme. Copyright © 2013 John Wiley & Sons, Ltd.
Psychosocial aspects of invasive fetal therapy as compared to prenatal diagnosis and risk assessment
Authors: Beck Veronika , Opdekamp Sandra , Enzlin Paul , Doné Elisa , Gucciardo Leonardo , El handouni Najima , van Mieghem Tim , Lewi Liesbeth , Deprest Jan 
Published: March 2013

ABSTRACTObjectiveTo explore the psychosocial impact of invasive fetal therapy (FT).MethodsWe studied 100 consecutive patients scheduled for invasive FT. Contemporary controls were women undergoing (1) invasive prenatal diagnosis (AC/CVS) and (2) first trimester risk assessment of aneuploidy (NT), and (3) women who declined the latter (CTR). Prior to the procedure, participants completed the Beck Depression Inventory II, the State‐Trait Anxiety Inventory, the Dyadic Adjustment Scale and a questionnaire specifically designed to evaluate the process preceding the intervention.ResultsThirty‐five percent of women in the FT group had mild to severe depressive symptoms, and 30% showed high levels of state anxiety. Mean state anxiety was significantly higher in women facing invasive as compared to non‐invasive procedures. Trait anxiety levels and relationship scores were comparable across all groups. FT patients were more satisfied with the information and support given, whereas women in the NT group felt a greater degree of self‐determination and contentedness with the choices they made.ConclusionPregnant women awaiting invasive prenatal diagnosis and FT face higher levels of state anxiety than women undergoing non‐invasive procedures. Traits of depression and high state anxiety are found in at least one third of women undergoing FT. © 2013 John Wiley & Sons, Ltd.
Cardiovascular safety and DPP‐4 inhibitors
Authors: Carty David M , Drummond Russell , Fisher Miles 
Published: March 2013

AbstractFollowing the rosiglitazone controversy there is a requirement from the licensing agencies that new antidiabetic drugs must be shown not to increase cardiovascular risk during phase 3 development. This includes studying patients with high cardiovascular risk, who were previously excluded from phase 3 studies. All of the currently available dipeptidyl peptidase (DPP)‐4 inhibitors (sitagliptin, vildagliptin, saxagliptin, linagliptin) have satisfied these safety criteria, with the suggestion that there might be some cardiovascular benefit with this class. Large randomised‐controlled trials are ongoing to assess safety as well as potential benefit. The results of these randomised‐controlled trials will influence the long‐term use of DPP‐4 inhibitors and their place in treatment guidelines. Copyright © 2013 John Wiley & Sons.
Predictors of depression, anxiety and quality of life in patients with prostate cancer receiving androgen deprivation therapy
Authors: Chipperfield Kelly , Fletcher Jane , Millar Jeremy , Brooker Joanne , Smith Robin , Frydenberg Mark , Burney Sue 
Published: March 2013

AbstractObjectivesTo evaluate the effects of androgen deprivation therapy (ADT) on depression, anxiety and quality of life (QoL) in patients with prostate cancer (PCa) and to examine the relationship between meeting the National Physical Activity Guidelines of Australia (NPAGA) and the presence and severity of both psychological sequelae and physical side effects associated with ADT. A secondary purpose was to examine the predictors of depression, anxiety and QoL in patients with PCa.MethodsA questionnaire was mailed to English‐speaking patients aged 40 to 80 years, who had received radiotherapy for PCa during 2010 and 2011, between 9 and 30 months prior to study initiation. Measures included the following: the International Physical Activity Questionnaire; the Hospital Anxiety and Depression Scale; the Functional Assessment of Cancer Therapy—Prostate; and sociodemographic items.ResultsLong‐term use of ADT was associated with poorer QoL and psychosocial well‐being. Those meeting NPAGA had significantly lower levels of depression and anxiety and improved QoL compared with those not meeting NPAGA. Logistic regression analyses showed the odds of clinically significant depression and anxiety scores, increased with younger age and comorbid conditions. Not meeting NPAGA increased the likelihood of caseness for depression. Multiple regression analyses revealed that comorbid conditions and treatment category predicted poorer QoL, whereas meeting NPAGA positively predicted QoL.ConclusionsThe use of ADT in the management of patients with PCa has a measurable effect on QoL. These findings support the utility of physical activity as an intervention for men undergoing ADT. Copyright © 2013 John Wiley & Sons, Ltd.
Disorder induced violet/blue luminescence in rf‐deposited ZnO films
Authors: Peres M. , Magalhães S. , Soares M. R. , Soares M. J. , Rino L. , Alves E. , Lorenz K. , Correia M. R. , Lourenço A. C. , Monteiro T. 
Published: March 2013

AbstractIn this work ZnO thin films were deposited on different substrates, glass, silicon (100), and MgO (100) using rf‐magnetron sputtering at low temperature in order to promote a large defect density, aiming to study a possible correlation with the observed violet/blue emission band. The peak position, width and low energy band shape asymmetry of the violet/blue band was found to be dependent on the deposition temperature and oxygen partial pressure. The structural analysis of deposited films reveals an epitaxial relationship for the a ‐oriented ZnO/MgO while for the c ‐oriented ZnO/Si no epitaxial relation was found with the substrate. The dependence of the violet/blue band on temperature displays always a shift of the peak position to lower energies, discarding the hypothesis of a free to bound transition. The sublinear dependence of the emission intensity with the excitation intensity suggests that the violet/blue bands on both samples could have a donor‐acceptor pair nature. However, the unusually strong shift of the peak position to lower energies for the ZnO/MgO films and the emphasised asymmetric band shape for the ZnO/Si samples suggest that potential fluctuations in the electronic bands, due to disorder induced charged defects, could also be considered as an alternative recombination model for the violet/blue band. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Anti‐biofilm Effects of Honey Against Wound Pathogens Proteus mirabilis and Enterobacter cloacae
Authors: Majtan Juraj , Bohova Jana , Horniackova Miroslava , Klaudiny Jaroslav , Majtan Viktor 
Published: March 2013

Biofilm growth and its persistence within wounds have recently been suggested as contributing factors to impaired healing. The goal of this study was to investigate the anti‐biofilm effects of several honey samples of different botanical origin, including manuka honey against Proteus mirabilis and Enterobacter cloacae wound isolates.Quantification of biofilm formation was carried out using a microtiter plate assay. All honeys at a sub‐inhibitory concentration of 10% (w/v) significantly reduced the biofilm development of both isolates. Similarly, at a concentration of 50% (w/v), each of the honeys caused significant partial detachment of Pr. mirabilis biofilm after 24 h. On the other hand, no honey was able to significantly detach Ent. cloacae biofilm. In addition, treatment of Ent. cloacae and Pr. mirabilis biofilms with all honeys resulted in a significant decrease in colony‐forming units per well values in a range of 0.35–1.16 and 1.2–7.5 log units, respectively.Of the tested honeys, manuka honey possessed the most potent anti‐biofilm properties. Furthermore, methylglyoxal, an antibacterial compound of manuka honey, was shown to be responsible for killing biofilm‐embedded wound bacteria.These findings suggest that manuka honey could be used as a potential therapy for the treatment of wounds containing Pr. mirabilis or Ent. cloacae. Copyright © 2013 John Wiley & Sons, Ltd.
Identification and quantification of poly(amidoamine) PAMAM dendrimers of generations 0 to 3 by liquid chromatography/hybrid quadrupole time‐of‐flight mass spectrometry in aqueous medium
Authors: Ulaszewska Maria Malgorzata , Hernando Maria Dolores , Moreno Ana Uclés , García Antonio Valverde , Calvo Eloy García , Fernández‐Alba Amadeo R. 
Published: March 2013

RATIONALEPoly(amidoamine) PAMAM dendrimers are highly water soluble and are used as flexible scaffolding or nanocontainers to conjugate, complex or encapsulate therapeutic drugs to overcome intrinsically weak characteristics such as solubilization in aqueous medium. To provide a reliable method for the quantitation of PAMAM dendrimers in aqueous medium, we report here a validation study which was developed in a complex wastewater matrix to evaluate the matrix effect in the electrospray ionization (ESI) source.METHODSPAMAM dendrimers (generations G0 to G3) were identified and quantitated in aqueous medium using liquid chromatography interfaced to a hybrid quadrupole/time‐of‐flight mass analyzer. This approach used the high resolving power of isotopic clusters and mass accuracy of the instrument, with especial attention to the tandem mass spectrometric (MS/MS) capabilities. The formation of multiply charged ions of PAMAM dendrimers in the ESI source and their later fragmentation allowed fragmentation paths to be determined and structural assignments to be made.RESULTSThe analytical strategy allowed dendrimer identification with a high degree of confidence obtained by accurate mass and high resolution with mass errors below 5 ppm and 10 ppm in MS and MS/MS modes. The parameters of validation in spiked matrix were: limits of quantification in the range of 0.12 to 1.25 μM depending on the generation, linearity (R >0.996), repeatability (R.S.D. <6.7%) and reproducibility (R.S.D. <10.8%).CONCLUSIONSAccurate mass measurement, elemental composition, and charge state assignment through the resolution of isotopic clusters of product and precursor ions, confers enhanced confidence on PAMAM dendrimer characterization. This selectivity provided high discriminating capacity of PAMAM dendrimers against matrix interferences. Because of the reliable and reproducible quantitation by LC/ESI‐QTOF‐MS, analysis of PAMAM dendrimers in an aqueous matrix is feasible. Copyright © 2013 John Wiley & Sons, Ltd.