bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the Metabolic Destiny of Potentilla discolor Bge. Extract and Its Primary Components in Rat Models
Authors: Dang Yanxin , Du Menghan , Sun Xiuxiu , Sun Zeqi , Liu Jie , Xie Minzhen , Chen Zhouxiu , Gu Siqi , Wang Qi , Liu Guijun 
Published: August 2024

Background:
Potentilla discolor Bge. is a plant extensively utilized in Traditional Chinese
Medicine (TCMs). Nevertheless, our knowledge of the chemical components and metabolic
complexities in its extracts is still quite limited.

Objective:
The study aimed to thoroughly analyze the flavonoid metabolism in Potentilla discolor
Bge. extracts and conduct a pharmacodynamic evaluation.

Methods:
In this study, we investigated the metabolism of flavonoids in Potentilla discolor Bge.
extracts using SD rats. The research adopted the strategy of “in vivo metabolism assessment, basic
study of pharmacodynamics and preliminary evaluation of molecular docking” to systematically
investigate the pharmacodynamic substances and targets of action of Potentilla discolor Bge..

Results:
The results of the study showed that the main metabolic forms of Potentilla discolor Bge.
in vivo include hydroxylation, methylation, and glycosylation. Among them, luteolin in the total
flavonoids of Potentilla discolor Bge. has the strongest antimicrobial and antioxidant ability. Outcomes
of molecular docking experiments indicated that the glycosylated metabolite of luteolin
had a significant advantage in acting with Glp-1 (Glucagon-like peptide-1).

Conclusion:
The present study revealed the metabolic pathways of total flavonoids in Potentilla
discolor Bge. It not only effectively screened out their pharmacodynamic substances and targets
but also provided a theoretical basis for the application of TCMs into a systematic application and
also provided ideas for the direction of drug optimization in the future. However, the sample range
of this study is limited, and it generalizability needs to be investigated.
An Association of Framingham Risk Score with Patient Determined Disease Steps in a Cohort of Relapsing-Remitting Multiple Sclerosis Patients: An Italian Real-World Monocentric Experience
Authors: Zanghi Aurora , Di Filippo Paola Sofia , Avolio Carlo , D’Amico Emanuele 
Published: August 2024

Background:
The associations between Multiple Sclerosis (MS) and cardiovascular diseases,
drawn from epidemiological studies, have attracted much attention in recent years.

Materials and Methods:
The present study employed a monocentric, observational, retrospective cohort
design. The primary objective of the study was to describe the Framingham Risk Score (FRS) rate
in a cross-sectional analysis of our cohort of relapsing-remitting MS patients who are regularly followed
up and, if applicable, to identify any association with the patient's Patient Determined Disease
Steps (PDDS). Cardiovascular risk was classified as follows: low if the FRS is less than 10%, moderate
if it is 10% to 19%, and high if it is 20% or higher.

Results:
A total cohort of 229 patients was enrolled. The sample consists of 163 women (71.2%). FRS
categories were distributed as follows: 97 (42.3%) patients had low FRS, 84 (36.7%) patients had
moderate FRS, and 48 (21%) patients had high FRS. In the univariable ordinal regression analysis, one
one-point increase in the PDDS scale was associated with a 24% risk of high FRS (vs. low) (proportional
odds ratio [OR] =2.426, 95% confidence interval [CI] 1.660-3.545; p <.0001). The results were
also confirmed by the EDSS score, with a point increase in the EDSS score associated with a 19% risk
of high FRS (vs. low) (proportional OR =1.953, 95% CI 1.429-2.669-1.04; p <.0001).

Conclusion:
The FRS demonstrated an association with the patient's “perception of the disease” as
indicated by the PDDS. Further studies with larger cohorts are needed to adequately address cardiovascular
risk in life-threatening conditions, such as MS.
Rancang Bangun Sistem Informasi Geografis Pemetaan Penduduk menggunakan Metode Personal Extreme Programing (Studi Kasus: Desa Oro-oro Ombo)
Authors: Firmansyah Firmansyah , Nuryasin Ilyas , Wahyuni Evi Dwi 
Published: August 2024

Desa Oro-oro Ombo adalah sebuah desa di wilayah Kecamatan Batu, Kota Batu,Provinsi Jawa Timur. Desa Oro-Oro Ombo merupakan sebuah desa yang berada di wilayah Kecamatan Batu Kota Batu, kurang lebih berjarak 2 km di sebelah selatan Kantor Camat Batu. Proses penginputan data penduduk di ikantor Desa Oro-Oro Ombo masih belum terkontrol menggunakan sistem iinformasi. Proses pencatatan data penduduk yaitu masih pakai Microsoft excel. Laporan yang diserahkan kepada kepala Kesejahteraan Masyarakat diperoleh dari penginputan data dari Microsoft excel yang direkap dan kemudian dijadikan laporan jumlah penduduk. Laporan tersebut inantinya akan digunakan sebagai pengambilan keputusan. Sehingga dapat mengambil keputusan untuk melakukan pembangunan di Desa Oro-Oro Ombo. Tujuan dari penelitian ini adalah untuk mengembangkan sistem PXP pada pengelola desa. Adapun dalam metode pengembangan ini menggunakan Personal extreme programming (PXP). Personal Extreme Programming merupakan ipengembangan dari extreme programming yang bisa digunakan oleh pengembang tunggal. Sistem yang akan dibangun dalam ipenelitian ini merupakan sistem pelayanan sistem terpadu desa. Kesimpulannya metode PXP ini bisa diimplementasikan pada studi kasus ini. Adapun dalam prosesnya dimulai dengan melakukan pengumpulan kebutuhan, diskusi dengan klien, kemudian kebutuhan klien tersebut dipresentasikan menjadi user Stories. User Stories Nya berjumlah 5 user Stories. Setelah mendapatkan kebutuhan sistem, maka melakukan pengembangan, perencanaan terdiri dari estimasi waktu, prioritas, dan penentuan user Stories di setiap iterasi.
KINERJA KEUANGAN PERUSAHAAN TEKSTIL DAN GARMEN SEBELUM DAN SELAMA PANDEMI COVID-19
Authors: Pattiruhu Dionisius Christopher Septa Hernawan , Tanggulungan Gustin 
Published: August 2024

Penelitian ini bertujuan memperoleh bukti empiris dan memperbandingkan kondisi kinerja keuangan perusahaan-perusahaan dalam industri tekstil dan garmen pada masa pada masa sebelum dan selama pandemi COVID-19. Industri tekstil dan garmen tercatat sebagai industri terbesar ketiga di Indonesia. Data berupa data sekunder yang diperoleh dari Bursa Efek Indonesia. Menggunakan teknik purposive sampling, terpilih 10 perusahaan tekstil dan garmen pada periode 2018-2022. Data dianalisis dengan rasio keuangan yang mencakup rasio likuiditas, solvabilitas, profitabilitas, dan aktivitas. Uji perbedaan kinerja untuk periode sebelum dan selama pandemi Covid-19 dilakukan dengan uji Wilcoxon menggunakan microsoft excel dan SPSS 27. Hasil penelitian menunjukkan kondisi keuangan perusahaan tekstil dan garmen cukup beragam. Uji beda menunjukkan ada perbedaan kinerja dalam ukuran DER dan TATO antara periode sebelum dan selama pandemi COVID-19 namun tidak ada perbedaan kinerja dalam ukuran CR, QR, DAR, NPM, ROA, GPM, dan ITO. Perusahaan yang melakukan invenstasi asset secara ekstensif pada masa sebelum pandemi menunjukkan DER dan TATO yang lebih buruk pada masa pandemi. Perusahaan yang berinovasi menproduksi APD menunjukkan kinerja yang lebih baik.
Anxieties, Desires and Sylvia: From Preparation to Beginning Teacher
Authors: Burnett Greg 
Published: August 2024

This paper makes a case for exploring underlying anxieties and desires possessed by final year teaching students prior to seeking employment in New Zealand schools. Anxieties and desires are understood in terms of ‘teaching’s intimacies’ (McConaghy, 2006), that is, the often unconscious and thus unspoken and unexplored feelings pre-service teachers have toward their teaching futures. Following calls by McConaghy (2006: 64), the reflections of at times controversial New Zealand educator Sylvia Ashton-Warner on her ‘inner life’ as a teacher, serve as both a type and a stimulus for the type of teacher reflection education students might also productively engage in. Reflective teacher practice of this type seeks to bridge the gap between the public and private worlds of teaching degree students during a significant period in their process of becoming teachers, the final year of their degrees. Reflection in this sense involves a greater ethic of care for the teaching self by addressing the silences in both teacher preparation and indeed the profession concerning teaching’s intimacies. Anecdotal evidence suggests relatively high departure rates from education programmes during degree programmes and also during the transition to teaching. The exploration of students’ anxieties and desires for teaching will contribute to understanding these problems.
Miss Honey was a wonderful teacher and a friend to everyone but her life was not as simple and wonderful as it seemed. Miss Honey had a secret. Though it caused her great pain she did not let it interfere with her teaching. from Matilda
Platelet lysate does not have an anti-inflammatory effect on monoiodoacetic acid–induced equine persistent synovitis
Authors: Fukuda Kentaro , Mita Hiroshi , Kuroda Taisuke , Tamura Norihisa , Kuwano Atsutoshi , Sato Fumio , Takahashi Toshiyuki 
Published: August 2024

Abstract

OBJECTIVE
To clarify the anti-inflammatory effect of platelet lysate (PL) on equine persistent synovitis by using a model of synovitis induced by monoiodoacetic acid (MIA).

METHODS
Nonseptic synovitis was induced by administering MIA into both antebrachiocarpal joints of 6 clinically healthy horses on day 0. On days 23, 30, and 37, carpal circumference measurement and synovial fluid collection for assays (leucocytes, LDH, tumor necrosis factor-α, and TGF-β1) were performed, after which PL was injected into 1 antebrachiocarpal joint and saline into the contralateral joint. Synovium and synovial fluid were obtained on day 44 for histological analysis and quantification of inflammation-related genes (matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs 4, receptor activator of nuclear factor κ-Β ligand, and collagen type I α2 chain) and the abovementioned proteins.

RESULTS
The LDH level on day 44 was significantly lower in the PL-injected joint than in the saline-treated one. However, no significant differences were found in the other indices quantified, including osteoclast counts on the synovium.

CONCLUSIONS
Multiple IA administration of PL does not exert anti-inflammatory effects on the equine persistent synovitis induced by MIA.

CLINICAL RELEVANCE
Intra-articular PL administration did not alter many inflammatory biomarkers, suggesting that PL does not have a direct anti-inflammatory effect. However, the reduction in synovial LDH levels suggests that PL promoted joint tissue repair and may consequently alleviate inflammation at the site of administration.
Social Housing Models in Latvia and A Comparative Analysis of the EU Member States
Authors: Sanchaniya Rashmi Jaymin , Sharma Medha , Kundziņa Antra 
Published: August 2024

Abstract
This study examines social housing models in Latvia, comparing them with those of other member states of the European Union (EU) through comparative and document analysis methodologies. The research investigates Latvia's current social housing landscape, its historical development, and the challenges in meeting the needs of vulnerable populations, particularly the elderly. Latvia’s social housing sector, characterised by a very small share of the total housing stock and quality issues, is compared with 3–5 EU countries, focussing on funding mechanisms, target groups, and quality standards. The analysis reveals significant disparities between Latvia and other EU countries in social housing provision, with Latvia having one of the lowest incidences in the EU. Key findings include the impact of demographic trends on housing needs and the challenges posed by the ageing housing stock. The study concludes with recommendations for policy improvements and implementation strategies, contributing to the understanding of social housing dynamics in Latvia within the broader EU context and providing information for more inclusive and sustainable housing solutions.
Navigating The Intersection of Management and AI: Advancing Occupational Health and Safety
Authors: Sira Mariya 
Published: August 2024

Abstract
This article provides an exploration of the intersection between management, artificial intelligence (AI), and occupational health and safety (OHS), delving into the evolution of safety systems and the integration of advanced technologies. To address the barriers to AI adoption in OHS and maximize the benefits of AI integration, the article proposes an AI Adoption Roadmap for OHS, delineating phases for assessment, planning, implementation, monitoring, continuous improvement, and the establishment of a data-driven safety culture. By embracing AI-driven solutions and fostering a culture of innovation and collaboration, organizations can proactively address safety challenges and cultivate safer, healthier work environments.
Social Factor to Determine Social Acceptance Toward ELV Management
Authors: Sitinjak Charli , Ismail Rozmi , Tahir Zurinah , Fajar Rizqon , Ober Józef 
Published: August 2024

Abstract
Indonesia, as a country with a highly developed automotive sector, is ranked 2nd under Thailand in the number of 4-wheeled vehicle production. However, the high number of automotive industries in Indonesia has directly threatened the high number of vehicles classified as end-of-life vehicles (ELV). Until now, Indonesia has been unable to address the ELV problem adequately; all efforts have been made to reduce the number of vehicles that are not suitable for use in Indonesia, such as the implementation of periodic emission tests, euro 2 and euro 4. Still, this regulation has not received a positive response from the public. This study attempts to test the previously designed acceptance model, in which external and internal factors from within the individual are considered. The findings of this study provide an overview of the social acceptance model for new policies, indicating that the government must consider each factor before developing and implementing new regulations.
Implementation of Industrial Accident Prevention Policies Based on an Investigation of Actual Conditions in an Explosives Manufacturing Plant
Authors: Krawczyk Dariusz , Maciejczyk Krzysztof 
Published: August 2024

Abstract
In order to establish principles for implementing requirements contained in legal acts regarding methods of preventing serious industrial accidents, a study of the procedures in place at NITROERG SA, a company manufacturing explosives, was conducted. The analysis also included regulations concerning actions to be taken in the event of an accident, aimed at minimizing negative impacts on people and the environment. Legislative solutions imply the necessity for business entities to submit reports to emergency services, while also carrying out a range of activities to counteract threats associated with serious accidents. This article presents how these recommendations are implemented by the company and the methods of obtaining data to improve the undertaken projects. However, incidents in recent years indicate the need for further verification of processes to eliminate risks.
USB Triggering of Video Recording in Sub-orbital Experiments
Authors: Lokhande Monish , Collicott Steven H. 
Published: August 2024

Abstract
Successful sub-orbital flight operations of a novel method for autonomously controlling GoPro cameras in microgravity, without any additional mechanical device, are described. The method employs the use of GoPro Labs software to control the power and recording functions of a camera via its USB port and integrates the camera and control with the Integrated Payload Controller (IPC) of the Blue Origin New Shepard crew capsule or with microprocessor control of cameras in Virgin Galactic’s VSS Unity. Control of four GoPro Hero-10 cameras on a single power port on the IPC is achieved. The method operated successfully on the Blue Origin New Shepard NS-24 suborbital flight, recording data in the experiment and demonstrating reliable start- and stop-recording functions during the flight. The authors also operated four GoPro Hero-11 cameras via USB port recording control on Virgin Galactic’s June 8, 2024 flight. Hardware specifications for the experimental setup and the ability to operate after extended periods of inactivity are discussed.
Field Applications of Fluorinated Nematicides for Meloidogyne enterolobii Management on Tomato
Authors: Castro-López R. , López-Orona C. A. , Martínez-Gallardo J. A. , Tirado-Ramírez M. A. , Gómez G. , Rubio-Aragón W. , Edeza-Urias J. A. , Villa-Medina M. C. 
Published: August 2024

Abstract
Mexico is the 8th largest producer of tomatoes. Meloidogyne enterolobii is reported in Sinaloa, affecting tomato cultivars with genetic resistance to Meloidogyne spp. We aimed to evaluate field applications of fluopyram, fluensulfone, and fluazaindolizine treatments for managing M. enterolobii on tomatoes. Experiments were set on raised beds in a shade house. Nematicides were applied via drip irrigation. Under fluopyram treatment, M. enterolobii did not reduce the number of extra-large-size fruits. The number of large-size fruits with fluopyram and fluazaindolizine plus fluopyram treatments was also unaffected by M. enterolobii. Yield from the treatments fluopyram, fluazaindolizine plus fluopyram, and fluensulfone plus fluopyram was similar to the control treatment without M. enterolobii. Finally, fluazaindolizine plus fluopyram, fluopyram, and fluensulfone plus fluopyram treatments showed the highest reduction of root galling. We conclude that the fluopyram was more effective as an individual treatment. Pre-plant applications of fluensulfone and fluazaindolizine reduced the damage to the plant and the loss of yield; however, the complementary application of fluorinated nematicides improved the management of M. enterolobii in the tomato crop.
Non-isothermal melt- and cold-crystallization, melting process, and optical and mechanical properties of PLLA: the effect of TAPH
Authors: Huang Hao , Lv Yang , Zhao Lisha , Tan Ninghui , Cai Yanhua 
Published: August 2024

Abstract
We synthesized a new phenylacetic hydrazide derivative (TAPH) by acylation and amination to prepare modified poly(L-lactide) (PLLA) materials. The non-isothermal melt- and cold-crystallization, melting process, optical and mechanical properties of modified PLLA were studied with the objective of correlating TAPH to PLLA crystallization and other performances. Non-isothermal melt crystallization showed that TAPH as a heterogeneous additive was able to promote crystallization and accelerate the crystallization rate of PLLA. Unfortunately, an increase in the cooling rate during cooling led to a decrease in crystallization ability. Non-isothermal cold-crystallization results disclosed that PLLA/TAPH’s cold-crystallization behavior depended on the heating rate; and upon a given heating rate, with an increase in TAPH loading, a shift toward the low-temperature side of the cold-crystallization peak further confirmed the nucleation effect of TAPH. The melting processes of PLLA/TAPH effectively depended on TAPH, the heating rate, and previous crystallization behaviors including non-isothermal crystallization and isothermal crystallization. Additionally, the double-melting peaks that appeared during the melt were thought to be due to melting-recrystallization. In terms of the optical property, the influence of TAPH on PLLA’s transparency was extremely negative as 2 wt% TAPH caused PLLA’s transparency to be zero. A comparative study on mechanical properties showed that TAPH could enhance PLLA’s tensile modulus and tensile strength, but elongation at break of any PLLA/TAPH was lower than that of pure PLLA.
Landscape Fragmentation and Deforestation in Sierra Leone, West Africa, Analysed Using Satellite Images
Authors: Lemenkova Polina 
Published: August 2024

Abstract
Monitoring rainforests in West Africa is necessary for natural resource management. Remote sensing is valuable for mapping tropical ecosystems and evaluation of landscape heterogeneity. This study presents landscape analysis in Sierra Leone which affects wildlife habitats and biodiversity. Methods include modules “r.mapcalc”, “r.li.mps”, “r.li.edgedensity”, and “r.forestfrag” of GRASS GIS for satellite image processing by computation of mean patch size, edge density index and landscape fragmentation with six levels: exterior, patch, transitional, edge, perforated, and interior. The results demonstrate increased deforestation and landscape fragmentation in Sierra Leone over a 10-year period (2013 to 2023).
KOZMA PRUTKOV AND GOTTLIEB BIEDERMEYER: TWO IMAGES OF THE SAME ERA
Authors: Иванова Е.Р. 
Published: August 2024

Статья посвящена сравнительному анализу образов Козьмы Пруткова и Готтлиба Бидермейера, ставших значимыми фигурами русской и немецкой литературы середины XIX века. Актуальность работы состоит в необходимости выявления степени их типологической схожести, для того чтобы обозначить общие и индивидуальные черты этих литературных персонажей. В статье рассматриваются прием образа-маски, сближающий этих героев, а также социальная и культурная сферы жизни общества, так как оба персонажа стали откликом на вызовы времени. К анализу привлекаются произведения, написанные от имени Козьмы Пруткова и Готтлиба Бидермейера, документальной основой исследования стали письма А.М. Жемчужникова и комментарии Л. Эйхродта. Аналитический акцент ставится на сопоставлении всех точек пересечения образов-масок с целью доказать, что Готтлиб Бидермейер не является «немецким вариантом» Козьмы Пруткова.
The article is devoted to a comparative analysis of the images of Kozma Prutkov and Gottlieb Biedermeyer, who became significant figures of Russian and German literature in the middle of the XIX century. The relevance of the work lies in the need to identify the degree of their typological similarity in order to identify the common and individual features of these literary characters. The article examines the technique of the image-mask, which brings these characters closer together, as well as the social and cultural spheres of society, since both characters have become a response to the challenges of the time. The works written on behalf of Kozma Prutkov and Gottlieb Biedermeyer are involved in the analysis, the documentary basis of the study were letters by A.M. Zhemchuzhnikov and comments by L. Eichrodt. The analytical emphasis is placed on comparing all points of intersection of images in order to prove that Gottlieb Biedermeyer is not a “German version” of Kozma Prutkov.