bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Efficient One‐Pot Five‐Component Tandem Sequential Approach for the Synthesis of Pyranopyrazole Derivatives via Suzuki Coupling and Multicomponent Reaction
Authors: Lu Zhangxiu , Xiao Jinlong , Wang Dongyang , Li Yiqun 
Published: February 2015

AbstractA one‐pot tandem sequential protocol for efficient synthesis of a series of new pyranopyrazole derivatives has been developed involving Suzuki coupling of 4‐bromobenzaldehyde and arylboronic acids followed by a four‐component reaction from readily available ethyl acetoacetate, malononitrile, and hydrazine hydrate. All of the products were fully characterized by melting point, FTIR, 1H NMR, and 13C NMR spectroscopy, and HRMS. The structure of one of the products was further established by X‐ray diffraction analysis. This method should provide a useful strategy for the construction of pyranopyrazole heterocycles.
Hippocampal sclerosis and TDP‐43 pathology in aging and Alzheimer disease
Authors: Nag Sukriti , Yu Lei , Capuano Ana W. , Wilson Robert S. , Leurgans Sue E. , Bennett David A. , Schneider Julie A. 
Published: February 2015

ObjectiveTo investigate the association of hippocampal sclerosis (HS) with TAR‐DNA binding protein of 43kDa (TDP‐43) and other common age‐related pathologies, dementia, probable Alzheimer disease (AD), mild cognitive impairment (MCI), and cognitive domains in community‐dwelling older subjects.MethodsDiagnoses of dementia, probable AD, and MCI in 636 autopsied subjects from the Religious Order Study and the Rush Memory and Aging Project were based on clinical evaluation and cognitive performance tests. HS was defined as severe neuronal loss and gliosis in the hippocampal CA1 and/or subiculum. The severity and distribution of TDP‐43 were assessed, and other age‐related pathologies were also documented.ResultsHS was more common in those aged >90 years (18.0%) compared to younger subjects (9.2%). HS cases commonly coexisted with TDP‐43 pathology (86%), which was more severe (p < 0.001) in HS cases. Although HS also commonly coexisted with AD and Lewy body pathology; only TDP‐43 pathology increased the odds of HS (odds ratio [OR] = 2.63, 95% confidence interval [CI] = 2.07–3.34). In logistic regression models accounting for age, TDP‐43, and other common age‐related pathologies, HS cases had higher odds of dementia (OR = 3.71, 95% CI = 1.93–7.16), MCI, and probable AD (OR = 3.75, 95% CI = 2.01–7.02). In linear regression models, including an interaction term for HS and TDP‐43 pathology, HS with coexisting TDP‐43 was associated with lower function in multiple cognitive domains, whereas HS without TDP‐43 did not have statistically significant associations. TDP‐43 without HS was separately related to lower episodic memory.InterpretationThe combined roles of HS and TDP‐43 pathology are significant factors underlying global cognitive impairment and probable AD in older subjects. Ann Neurol 2015;77:942–952
Defective fast inactivation recovery of Nav1.4 in congenital myasthenic syndrome
Authors: Arnold W. David , Feldman Daniel H. , Ramirez Sandra , He Liuyuan , Kassar Darine , Quick Adam , Klassen Tara L. , Lara Marian , Nguyen Joanna , Kissel John T. , Lossin Christoph , Maselli Ricardo A. 
Published: February 2015

ObjectiveTo describe the unique phenotype and genetic findings in a 57‐year‐old female with a rare form of congenital myasthenic syndrome (CMS) associated with longstanding muscle fatigability, and to investigate the underlying pathophysiology.MethodsWe used whole‐cell voltage clamping to compare the biophysical parameters of wild‐type and Arg1457His‐mutant Nav1.4.ResultsClinical and neurophysiological evaluation revealed features consistent with CMS. Sequencing of candidate genes indicated no abnormalities. However, analysis of SCN4A, the gene encoding the skeletal muscle sodium channel Nav1.4, revealed a homozygous mutation predicting an arginine‐to‐histidine substitution at position 1457 (Arg1457His), which maps to the channel's voltage sensor, specifically D4/S4. Whole‐cell patch clamp studies revealed that the mutant required longer hyperpolarization to recover from fast inactivation, which produced a profound use‐dependent current attenuation not seen in the wild type. The mutant channel also had a marked hyperpolarizing shift in its voltage dependence of inactivation as well as slowed inactivation kinetics.InterpretationWe conclude that Arg1457His compromises muscle fiber excitability. The mutant fast‐inactivates with significantly less depolarization, and it recovers only after extended hyperpolarization. The resulting enhancement in its use dependence reduces channel availability, which explains the patient's muscle fatigability. Arg1457His offers molecular insight into a rare form of CMS precipitated by sodium channel inactivation defects. Given this channel's involvement in other muscle disorders such as paramyotonia congenita and hyperkalemic periodic paralysis, our study exemplifies how variations within the same gene can give rise to multiple distinct dysfunctions and phenotypes, revealing residues important in basic channel function. Ann Neurol 2015;77:840–850
Investigation of the extraction process in gel‐spinning technology for ultrahigh‐molecular‐weight polyethylene fibers by low‐field nuclear magnetic resonance
Authors: Chen Meijuan , Jiang Binbo , Wang Jingdai , Yang Yongrong , Stapf Siegfried , Mattea Carlos , Gong Qingxia 
Published: February 2015

ABSTRACTA portable, low‐field nuclear magnetic resonance scanner, the nuclear magnetic resonance mobile universal surface explorer, is introduced as a tool for investigating the extraction process of mineral oil in the gel‐spinning technology of ultrahigh‐molecular‐weight polyethylene (UHMWPE) fibers. Factors affecting the extraction process were studied systematically; these included the UHMWPE type, extraction agent type, and concentration and ultrasound. We found that the extraction process could be described by a replacement–dilution dual‐effect model. The extraction agent not only replaced and extracted the mineral oil but also considerably decreased the viscosity of mineral oil and thus enhanced the molecular motion and diffusion of mineral oil. Although chloroform had a smaller molecular size and lower boiling point, benzene and cyclohexane were found to exhibit more efficient extraction and dilution effects on mineral oil. The extraction efficiency could be characterized by the diffusion of mineral oil in the mineral oil/UHMWPE gel/deuterated extraction agent multicomponent systems during the extraction. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42018.
Effects of glucose‐functionalized multiwalled carbon nanotubes on the structural, mechanical, and thermal properties of chitosan nanocomposite films
Authors: Mallakpour Shadpour , Madani Maryam 
Published: February 2015

ABSTRACTA series of multiwalled carbon nanotubes (MWCNTs) grafted by chitosan nanocomposite (NC) films were prepared by a direct blending process and solution casting method. In this study, we modified multiwalled carbon nanotubes with glucose (MWCNT–Gl) for this purpose, and the effects of MWCNT–Gl on the structural, mechanical, and thermal properties of chitosan films with different contents of MWCNT–Gl were investigated. The structure, thermal stability, and mechanical properties of the composite were examined by X‐ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and mechanical testing. The results indicate that the MWCNTs treated by glucose were dispersed well in the chitosan matrix, and the tensile properties of the NC films were improved greatly compared with neat chitosan. Also, with increasing MWCNT–Gl content, the crystalline nature of chitosan decreased. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42022.
Synthesis, Characterization, and Energetic Properties of 6‐Amino‐tetrazolo[1,5‐b]‐1,2,4,5‐tetrazine‐7‐N‐oxide: A Nitrogen‐Rich Material with High Density
Authors: Wei Hao , Zhang Jiaheng , Shreeve Jean'ne M. 
Published: February 2015

AbstractThe synthesis and energetic properties of a novel N‐oxide high‐nitrogen compound, 6‐amino‐tetrazolo[1,5‐b]‐1,2,4,5‐tetrazine‐7‐N‐oxide, are described. Resulting from the N‐oxide and fused rings system, this molecule exhibits high density, excellent detonation properties, and acceptable impact and friction sensitivities, which suggests potential applications as an energetic material. Compared to known high‐nitrogen compounds, such as 3,6‐diazido‐1,2,4,5‐tetrazine (DiAT), 2,4,6‐tri(azido)‐1,3,5‐triazine (TAT), and 4,4′,6,6′‐tetra(azido)azo‐1,3,5‐triazine (TAAT), a marked performance and stability increase is seen. This supports the superior qualities of this new compound and the advantage of design strategy.
Syntheses and luminescent properties of a copolymer of terbium‐p‐aminobenzoic acid–methacrylic acid and styrene
Authors: Zhang A. Q. , Yang Y. M. , Li L. P. , Zhai G. M. , Jia H. S. , Liu X. G. , Xu B. S. 
Published: February 2015

AbstractA reactive Tb(III) complex with p‐aminobenzoic acid (p‐ABA) and methacrylic acid (MAA) as ligands was synthesized. A novel copolymer was synthesized by free radical copolymerization of styrene and the reactive Tb(III) complex in dimethyl sulfoxide (DMSO) with 2,2′‐azobis(2‐methylpropionitrile) (AIBN) as the initiator. IR and UV/Vis spectra indicate that the copolymer exhibited absorption from polystyrene and the complex. Thermogravimetric analysis indicates that the copolymer remained stable up to 357°C and the thermal stability was significantly improved in comparison with polymer matrix and the Tb(III) complex. The luminescent intensity of the synthetic terbium macromolecular complexes increased with increasing complex monomer content. Moreover, concentration quenching was not observed. Copyright © 2015 John Wiley & Sons, Ltd.
Hospital teaching status and volume related to mortality after pancreatic cancer surgery in a national cohort
Authors: Derogar M , Blomberg J , Sadr-Azodi O 
Published: February 2015

Abstract

Background
The association between hospital teaching status and mortality after pancreatic resection is not well explored. Although hospital volume is related to short-term mortality, the effect on long-term survival needs investigation, taking into account hospital teaching status and selective referral patterns.

Methods
This was a nationwide retrospective register-based cohort study of patients undergoing pancreatic resection between 1990 and 2010. Follow-up for survival was carried out until 31 December 2011. The associations between hospital teaching status and annual hospital volume and short-, intermediate- and long-term mortality were determined by use of multivariable Cox regression models, which provided hazard ratios (HRs) with 95 per cent c.i. The analyses were mutually adjusted for hospital teaching status and volume, as well as for patients' sex, age, education, co-morbidity, type of resection, tumour site and histology, time interval, referral and hospital clustering.

Results
A total of 3298 patients were identified during the study interval. Hospital teaching status was associated with a decrease in overall mortality during the latest interval (years 2005–2010) (university versus non-university hospitals: HR 0·72, 95 per cent c.i. 0·56 to 0·91; P = 0·007). During all time periods, hospital teaching status was associated with decreased mortality more than 2 years after surgery (university versus non-university hospitals: HR 0·86, 0·75 to 0·98; P = 0·026). Lower annual hospital volume increased the risk of short-term mortality (HR for 3 or fewer compared with 4–6 pancreatic cancer resections annually: 1·60, 1·04 to 2·48; P = 0·034), but not long-term mortality. Sensitivity analyses with adjustment for tumour stage did not change the results.

Conclusion
Hospital teaching status was strongly related to decreased mortality in both the short and long term. This may relate to processes of care rather than volume per se. Very low-volume hospitals had the highest short-term mortality risk.
To know or not to know? Integrating ethical aspects of genomic healthcare in the education of health professionals
Authors: Eriksen Kathrine Krageskov 
Published: February 2015

AbstractNovel possibilities for employing genetic testing as part of the diagnostic process for a wide variety of diseases and conditions are emerging almost every day. This development brings prospects of more efficient treatment and prevention of serious and often lethal conditions. However, it also raises ethical questions concerning the issue of knowing or not knowing about our genetic make‐up. Thus, as techniques for genetic testing are increasingly employed, demands on health professionals are changing. Health professionals must be able to inform and guide patients, and therefore they need knowledge and competencies related to both the technical and the ethical dimensions of genetic testing. This paper explores the requirements of the general education of health professionals if this need for ethics is acknowledged. It is suggested that it is important to include both an individualised and a societal ethical perspective to the development of genomic healthcare and that a key concept in doing so is ‘professional reflectivity’. Employing one concrete example of teaching, this concept of reflectivity is operationalised in the health educational setting at the bachelor's level with a special focus on biomedical laboratory science, and three key concepts are developed: Gap sensitive interaction, professional humility, and contextual awareness. Additionally, anchored ethical dialog is explored as an instructional design that may support the development of reflectivity among health professionals. © 2015 by The International Union of Biochemistry and Molecular Biology, 43(2):81–87, 2015.
G551D‐CFTR needs more bound actin than wild‐type CFTR to maintain its presence in plasma membranes
Authors: Trouvé Pascal , Kerbiriou Mathieu , Teng Ling , Benz Nathalie , Taiya Mehdi , Le Hir Sophie , Férec Claude 
Published: February 2015

AbstractCystic Fibrosis is due to mutations in the CFTR gene. The missense mutation G551D (approx. 5% of cases) encodes a CFTR chloride channel with normal cell surface expression but with an altered chloride channel activity, leading to a severe phenotype. Our aim was to identify specific interacting proteins of G551D‐CFTR which could explain the channel defect. Wild‐type CFTR (Wt‐CFTR) was co‐immunoprecipitated from stably transfected HeLa cells and resolved by 2D gel electrophoresis. Among the detected spots, one was expressed at a high level. Mass Spectrometry revealed that it corresponded to actin which is known to be involved in the CFTR's channel function. To assess whether actin could be involved in the altered G551D‐CFTR function, its basal expression was studied. Because actin expression was the same in wt‐ and in G551D‐CFTR expressing cells, its interaction with both wt‐ and G551D‐CFTR was studied by co‐immunoprecipitation, and we found that a higher amount of actin was bound onto G551D‐CFTR than onto Wt‐CFTR. The role of actin upon wt‐ and G551D‐CFTR function was further studied by patch‐clamp experiments after cytochalasin D treatment of the cells. We found a decrease of the very weak currents in G551D‐CFTR expressing cells. Because a higher amount of actin is bound onto G551D‐CFTR than onto Wt‐CFTR, it is likely to be not involved in the mutated CFTR's defect. Nevertheless, because actin is necessary to maintain the very weak global currents observed in G551D‐CFTR expressing HeLa cells, we conclude that more actin is necessary to maintain G551D‐CFTR in the plasma membrane than for Wt‐CFTR.
Ferrocene‐Boronic Acid–Fructose Binding Based on Dual‐Plate Generator–Collector Voltammetry and Square‐Wave Voltammetry
Authors: Li Meng , Xu Su‐Ying , Gross Andrew J. , Hammond Jules L. , Estrela Pedro , Weber James , Lacina Karel , James Tony D. , Marken Frank 
Published: February 2015

AbstractThe interaction of ferrocene‐boronic acid with fructose is investigated in aqueous 0.1 M phosphate buffer at pH 7, 8 and 9. Two voltammetric methods, based on 1) a dual‐plate generator–collector micro‐trench electrode (steady state) and 2) a square‐wave voltammetry (transient) method, are applied and compared in terms of mechanistic resolution. A combination of experimental data is employed to obtain new insights into the binding rates and the cumulative binding constants for both the reduced ferrocene‐boronic acid (pH dependent and weakly binding) and for the oxidised ferrocene‐boronic acid (pH independent and strongly binding).
Dynamic Combinatorial Enrichment of Polyconformational D‐/L‐Peptide Dimers
Authors: Jadhav Kirtikumar B. , Lichtenecker Roman J. , Bullach Anke , Mandal Bhubaneswar , Arndt Hans‐Dieter 
Published: February 2015

AbstractD‐/L‐Peptides such as gramicidin A (gA) adopt unique dimeric β‐helical structures of different topologies. To overcome their conformational promiscuity and enrich individual components, a dynamic combinatorial approach assisted by thiol tags was developed. This method led to identification of the preferential formation of antiparallel dimers under a broad range of conditions, which was independent of peptide side‐chain polarity. Exclusive formation of an antiparallel cyclic dimer was achieved in the presence of cesium ions.
ChemInform Abstract: Molten Salt Synthesis of Nano‐Sized Li4Ti5O12 Doped with Fe2O3 for Use as Anode Material in the Lithium‐Ion Battery.
Authors: Guo Qingjun , Li Shiyan , Wang Heng , Gao Yuan , Li Bing 
Published: February 2015

AbstractSingle‐phase Li4Ti5‐xFexO12 (x = 0, 0.1, 0.2, 0.3) are prepared from LiOH, TiO2, and Fe2O3 in LiCl‐KCl molten salt (corundum crucible, 800 °C, 4 h).
ChemInform Abstract: Sunlight‐Driven Hydrogen Peroxide Production from Water and Molecular Oxygen by Metal‐Free Photocatalysts.
Authors: Shiraishi Yasuhiro , Kanazawa Shunsuke , Kofuji Yusuke , Sakamoto Hirokatsu , Ichikawa Satoshi , Tanaka Shunsuke , Hirai Takayuki 
Published: February 2015

AbstractPyromellitic diimide is incorporated into graphitic carbon nitride, g‐C3N4 by calcination of a mixture of melem and pyromellitic dianhydride at 598 K for 4 h.
ChemInform Abstract: Xenon(II) Polyfluoridotitanates(IV): Synthesis and Structural Characterization of [Xe2F3]+ and [XeF]+ Salts.
Authors: Radan Kristian , Goreshnik Evgeny , Zemva Boris 
Published: February 2015

AbstractThermal reaction between XeF2 and excess TiF4 (evacuated reaction vessel, ‐196 → +135 °C, 12 h) results in the formation of the highly ionized XeII species [Xe2F3][Ti8F33] (I) and [XeF]2[Ti9F38] (II) which represent [Xe2F3]+ and [XeF]+ compounds differing from known XeII salts containing discrete F‐ anions with pentavalent metalloid/metal centers.
ChemInform Abstract: Direct Intramolecular Conjugate Addition of Simple Alkenes to α,β‐Unsaturated Carbonyls Catalyzed by Cu(OTf)2.
Authors: Qin Yan , Lv Jian , Luo Sanzhong , Cheng Jin‐Pei 
Published: February 2015

AbstractBismuth triflate shows higher activities in the intramolecular addition of sulfonimine (XI) to give vinyl amine (XII).
ChemInform Abstract: Iron/Acetic Acid Mediated Intermolecular Tandem C—C and C—N Bond Formation: An Easy Access to Acridinone and Quinoline Derivatives.
Authors: Rajawinslin R. R. , Gawande Sachin D. , Kavala Veerababurao , Huang Yi‐Hsiang , Kuo Chun‐Wei , Kuo Ting‐Shen , Chen Mei‐Ling , He Chiu‐Hui , Yao Ching‐Fa 
Published: February 2015

AbstractVarious substituted acridinones, quinolines, and biologically active compounds are obtained by an one‐pot reductive cyclization protocol under mild reaction conditions.
ChemInform Abstract: Triflic Acid‐Catalyzed C(sp3)—H Functionalization of 2‐Methyl Azaarenes with a α‐Trifluoromethyl Imino Ester.
Authors: Blocker Mark , Immaneni Supriya , Shaikh Abid 
Published: February 2015

AbstractTriflic acid catalyzes both the functionalization of 2‐alkyl azaarenes and concomitant N‐deprotection of imino ester (II).
ChemInform Abstract: Regioselective Acetylation of Carbohydrates and Diols Catalyzed by Tetramethyl‐Ammonium Hydroxide in Water.
Authors: Lu Yuchao , Wei Peng , Pei Yuxin , Xu Hengfu , Xin Xiaoting , Pei Zhichao 
Published: February 2015

AbstractThe eco‐friendly approach occurs selectively for primary over secondary alcohols.
ChemInform Abstract: Metal‐Free Metathesis Reaction of C‐Chiral Allylic Sulfilimines with Aryl Isocyanates: Construction of Chiral Nonracemic Allylic Isocyanates.
Authors: Grange Rebecca L. , Evans P. Andrew 
Published: February 2015

AbstractC‐chiral allylic sulfilimines primarily react with aryl isocyanates and the intermediary formed allylic isocyanates are trapped with nucleophiles giving unsymmetrical ureas, carbamates, thiocarbamates, and amides.
ChemInform Abstract: Iridium‐Catalyzed Enantioselective Allyl—Allylsilane Cross‐Coupling.
Authors: Hamilton James Y. , Hauser Nicole , Sarlah David , Carreira Erick M. 
Published: February 2015

AbstractThe operationally simple cross‐coupling reaction of allylic alcohols and allylsilanes provides 1,5‐dienes with high regioselectivity and excellent enantioselectivity.
ChemInform Abstract: Dual Catalysis with Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols: Efficient Synthesis of α‐Trifluoromethylated Enones.
Authors: Egami Hiromichi , Ide Takafumi , Fujita Masashi , Tojo Toshifumi , Hamashima Yoshitaka , Sodeoka Mikiko 
Published: February 2015

AbstractUsing the dual catalytic system cuprous iodide / rhenium heptoxide, an efficient trifluoromethylation of propargylic alcohols with Togni′s reagent II is achieved.
ChemInform Abstract: Palladium‐Catalyzed Direct Addition of Arylboronic Acids to 2‐Aminobenzonitrile derivatives: Synthesis, Biological Evaluation and in Silico Analysis of 2‐Aminobenzophenones, 7‐Benzoyl‐2‐oxoindolines, and 7‐Benzoylindoles.
Authors: Chen Jiuxi , Ye Leping , Su Weike 
Published: February 2015

Abstract3,4,5‐trimethoxy‐2′‐aminobenzophenones (IIIf) and (VIIg) as well as indolinone (IX) and indole (XI) derivatives display remarkable activity against H446 (human lung carcinoma), HGC‐27 (human gastric cancer), and SGC‐7901 (human gastric cancer) cell lines (cis‐platin as reference) with compounds (IXa) and (IXf) as most potent agents.
ChemInform Abstract: Synthesis of Arylsulfonyl‐Quinones and Arylsulfonyl‐1,4‐diols as FabH Inhibitors: Pd‐Catalyzed Direct C‐Sulfone Formation by C—S Coupling of Quinones with Arylsulfonyl Chloride.
Authors: Ge Bingyang , Wang Dawei , Dong Weifu , Ma Piming , Li Yongliang , Ding Yuqiang 
Published: February 2015

AbstractA facile protocol is developed for the coupling of quinones with arysulfonyl chlorides to give arylsulfonyl quinones, which can be easily reduced to the corresponding 1,4‐diols.
ChemInform Abstract: Conjugate Umpolung of β,β‐Disubstituted Enals by Dual Catalysis with an N‐Heterocyclic Carbene and a Broensted Acid: Facile Construction of Contiguous Quaternary Stereocenters.
Authors: Li Jun‐Long , Sahoo Basudev , Daniliuc Constantin‐G. , Glorius Frank 
Published: February 2015

AbstractThe diastereoselective reaction of isatins with β,β‐disubstituted enals by NHC/Broensted acid dual catalysis is demonstrated to give spirocyclic butyrolactones in good yields and diastereoselectivities.
ChemInform Abstract: Diastereoselective Synthesis of Spiro[cyclopropane‐1,3′‐indolin]‐2′‐ones Through Metal‐Free Cyclopropanation Using Tosylhydrazone Salts.
Authors: Kapure Jeevak Sopanrao , Reddy Chada Narsimha , Adiyala Praveen Reddy , Nayak Ranjita , Nayak V. Lakshma , Nanubolu Jagadeesh Babu , Singarapu Kiran Kumar , Maurya Ram Awatar 
Published: February 2015

AbstractThe synthesized compounds are evaluated towards their anti‐cancer properties against three different human cancer cell lines with (VIIa) and (IXb) showing promising activities.
ChemInform Abstract: A Solvent‐Free and One‐Pot Strategy for Ecocompatible Synthesis of Substituted Benzofurans from Various Salicylaldehydes, Secondary Amines, and Nonactivated Alkynes Catalyzed by Copper(I) Oxide Nanoparticles.
Authors: Sharghi Hashem , Shiri Pezhman , Aberi Mahdi 
Published: February 2015

AbstractAromatic amines such as aniline and 4‐chloroaniline are unreactive under the developed conditions.