bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arcanes de Montréal : la métropole dans les romans de Nelly Arcan
Authors: Dupuis Gilles 
Published: April 2015

Montréal est au coeur de l’oeuvre romanesque de l’écrivaine québécoise Nelly Arcan. Non seulement la métropole fournit-elle le décor à l’intrigue des quatre romans de l’auteure, mais aussi elle s’émancipe progressivement de sa seule fonction de cadre pour constituer, d’un opus à l’autre, un topos à part entière du récit, inséparable du sort des personnages qui y jouent leur destin. Tour à tour sordide et branchée à travers les quartiers de prédilection fréquentés par la romancière, virtuelle et fantastique dans le passage remarqué de l’autofiction à la science-fiction, la ville désirante mise en scène par Nelly Arcan ne livre pas d’emblée tous ses secrets. C’est en interrogeant les arcanes de l’oeuvre, à la lumière de Montréal interdite d’Alain Médam et de Paris insolite de Jean-Paul Cléber, que la cybermétropole arcanienne révèle sa part insoupçonnée de mystère.
Le Papineau de Louis Fréchette : l’exproprié de l’histoire
Authors: Livernois Jonathan 
Published: April 2015

On note une importante fictionnalisation de la figure de Louis-Joseph Papineau (1786-1871) dans le corpus littéraire canadien-français du XIXe et du début du XXe siècle. Louis Fréchette (1839-1908), dans ses poèmes, dans le drame Papineau ainsi que dans ses Mémoires intimes, magnifie le chef du Parti patriote, lui confère un statut de grand homme politique, de la trempe de Cicéron et de Caton. Pourtant, du même souffle, la figure de Papineau est subrepticement désamorcée, déradicalisée. Dans cette étude, nous verrons les ressorts littéraires qui expliquent ce double phénomène et ce qu’ils peuvent révéler des rapports entre la politique et la littérature canadiennes-françaises puis québécoises.
Lewis Acid‐Catalyzed or Base‐Promoted Regioselective Cycloisomerization of N‐Imidoyl‐o‐alkynylanilines for Synthesis of N‐Imidoyl‐(1 H)‐indoles and 4‐Alkylidene‐3,4‐dihydroquinazolines
Authors: Otani Takashi , Jiang Xue , Cho Kinryo , Araki Rino , Kutsumura Noriki , Saito Takao 
Published: April 2015

AbstractProduct selectivity control for the synthesis of imidoylindoles and 4‐alkylidenedihydroquinazolines from N‐imidoyl‐o‐alkynylanilines via silver triflate‐catalyzed cycloisomerization or tetrabutylammonium fluoride‐promoted cyclization is described. The product selectivity depends mainly on the catalyst/promoter used, and on the substituents on the alkyne and amidine functions of the substrates.magnified image
Carboxylic‐Acid‐Passivated Metal Oxide Nanocrystals: Ligand Exchange Characteristics of a New Binding Motif
Authors: De Roo Jonathan , Justo Yolanda , De Keukeleere Katrien , Van den Broeck Freya , Martins José C. , Van Driessche Isabel , Hens Zeger 
Published: April 2015

AbstractLigand exchange is central in the processing of inorganic nanocrystals (NCs) and requires understanding of surface chemistry. Studying sterically stabilized HfO2 and ZrO2 NCs using 1H solution NMR and IR spectroscopy as well as elemental analysis, this paper demonstrates the reversible exchange of initial oleic acid ligands for octylamine and self‐adsorption of oleic acid at NC surfaces. Both processes are incompatible with an X‐type binding motif of carboxylic acids as reported for sulfide and selenide NCs. We argue that this behavior stems from the dissociative adsorption of carboxylic acids at the oxide surface. Both proton and carboxylate moieties must be regarded as X‐type ligands yielding a combined X2 binding motif that allows for self‐adsorption and exchange for L‐type ligands.
Regioselective Ring‐Opening Polymerization of a Polyhydroxycarboxylic Acid for the Synthesis of a Nanoscale Carrier Material with pH‐Dependent Stability and Sustained Drug Release
Authors: Ewe Alexander , Jansen de Salazar Anita , Lemmnitzer Katharina , Marsch Michael , Aigner Achim , Geyer Armin 
Published: April 2015

AbstractSynthetic polyesters are usually composed of monohydroxycarboxylic acids to avoid the problem of regioselectivity during ring‐opening polymerization. In contrast, the linear polyester BICpoly contains four secondary OH groups and is nevertheless esterified regioselectively at only one of these positions. Neither the synthesis of the tricyclic monomers nor the ring‐opening polymerization requires protecting groups, making BICpoly an attractive novel and biocompatible polymer. BICpoly nanoparticles can be loaded with low‐molecular weight drugs or coated onto surfaces as thin films. The release of loaded compounds makes BICpoly an attractive depot for drug release, as shown herein by loading BICpoly with dyes or the cytostatic drug doxorubicin. BICpoly is distinguishable from other polymers by its characteristic pH‐dependent degradation.
Shape without Structure: An Intriguing Formation Mechanism in the Solvothermal Synthesis of the Phase‐Change Material Sb2Te3
Authors: Saltzmann Tobias , Bornhöfft Manuel , Mayer Joachim , Simon Ulrich 
Published: April 2015

AbstractWe introduce a novel solvothermal synthesis of individual single crystalline Sb2Te3 micro‐ and nanocrystals as a model material for phase‐change switching. We identified different intermediates along the reaction path to the final Sb2Te3 hexagonal platelets (HPs) and discuss their forming mechanism. By means of nanodiffraction (ND) in a scanning transmission electron microscope we demonstrate that the intermediates follow a hexagonal shape evolution in the amorphous state. In situ nanomanipulator measurements reveal electrical phase‐change switching properties of the individual Sb2Te3 hexagonal platelets.
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
Authors: Clark Peter G. K. , Vieira Lucas C. C. , Tallant Cynthia , Fedorov Oleg , Singleton Dean C. , Rogers Catherine M. , Monteiro Octovia P. , Bennett James M. , Baronio Roberta , Müller Susanne , Daniels Danette L. , Méndez Jacqui , Knapp Stefan , Brennan Paul E. , Dixon Darren J. 
Published: April 2015

AbstractThe bromodomain‐containing proteins BRD9 and BRD7 are part of the human SWI/SNF chromatin‐remodeling complexes BAF and PBAF. To date, no selective inhibitor for BRD7/9 has been reported despite its potential value as a biological tool or as a lead for future therapeutics. The quinolone‐fused lactam LP99 is now reported as the first potent and selective inhibitor of the BRD7 and BRD9 bromodomains. Development of LP99 from a fragment hit was expedited through balancing structure‐based inhibitor design and biophysical characterization against tractable chemical synthesis: Complexity‐building nitro‐Mannich/lactamization cascade processes allowed for early structure–activity relationship studies whereas an enantioselective organocatalytic nitro‐Mannich reaction enabled the synthesis of the lead scaffold in enantioenriched form and on scale. This epigenetic probe was shown to inhibit the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. Moreover, LP99 was used to demonstrate that BRD7/9 plays a role in regulating pro‐inflammatory cytokine secretion.
Sensory Hairs in the Bowhead Whale, Balaena mysticetus (Cetacea, Mammalia)
Authors: Drake Summer E. , CRISH Samuel D. , George John C. , Stimmelmayr Raphaella , Thewissen J.G.M. 
Published: April 2015

ABSTRACTWe studied the histology and morphometrics of the hairs of bowhead whales (Balaena mysticetus). These whales are hairless except for two patches of more than 300 hairs on the rostral tip of the lower lip and chin, the rostral tip of the upper lip, and a bilateral row of approximately ten hairs caudal to the blowhole. Histological data indicate that hairs in all three of these areas are vibrissae: they show an outermost connective tissue capsule, a circumferential blood sinus system surrounding the hair shaft, and dense innervation to the follicle. Morphometric data were collected on hair diameters, epidermal recess diameters, hair follicle length, and external hair lengths. The main difference between the hairs in the different regions is that blowhole hairs have larger diameters than the hairs in the chin and rostrum regions. We speculate that the hair shaft thickness patterns in bowheads reflect functional specializations. Anat Rec, 298:1327–1335, 2015. © 2015 Wiley Periodicals, Inc.
Pectin: A new perspective from the biorefinery standpoint
Authors: Ciriminna Rosaria , Chavarría‐Hernández Norberto , Inés Rodríguez Hernández Adriana , Pagliaro Mario 
Published: April 2015

AbstractPectin is a natural product of central importance in the emerging biorefinery that uses fruit waste as a raw material. Generally obtained from lemon peel or from apple pomace, pectin is mainly used as a thickener and a stabilizer in the food industry. Due to its unique chemical properties and biochemical activity, however, its use is growing in many other sectors. Providing a unified view of the main research and utilization trends, this study identifies open opportunities toward larger scale production of a valued biopolymer that, we argue, will shortly emerge as a central product of the biorefinery, and of the citrus‐based biorefinery in particular. © 2015 Society of Chemical Industry and John Wiley & Sons, Ltd
Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development
Authors: Wang Jing , Iyer Suhasini , Fielder Paul J. , Davis John D. , Deng Rong 
Published: April 2015

AbstractCurrently, more than 350 monoclonal antibodies (mAbs) and mAb derivatives are under development as therapeutics. The prediction of mAb pharmacokinetics (PK)/pharmacodynamics (PD) plays a key role in starting dose selection for first‐in‐human (FIH) studies. This article presents a brief overview of the biology and mechanisms of absorption, distribution, metabolism and excretion (ADME) for mAbs. In addition, a detailed review of mAb human PK/PD prediction from nonclinical data is provided, including allometry for mAbs with linear or nonlinear PK, species‐invariant time method, physiologically based PK (PBPK) modeling and target‐mediated drug disposition (TMDD) model, bioavailability projection and immunogenicity impact on PK prediction. Finally, from an industry perspective a decision tree of mAb human PK projection is proposed to facilitate drug development. Copyright © 2015 John Wiley & Sons, Ltd.
Plasma thrombospondin 1 as a predictor of postoperative liver dysfunction
Authors: Starlinger P , Haegele S , Wanek D , Zikeli S , Schauer D , Alidzanovic L , Fleischmann E , Gruenberger B , Gruenberger T , Brostjan C 
Published: April 2015

Abstract

Background
Liver regeneration following liver resection involves a complex interplay of growth factors and their antagonists. Thrombospondin 1 has recently been identified as a critical inhibitor of liver regeneration by the activation of transforming growth factor β1 in mice, and preliminary data seem to confirm its relevance in humans. This study aimed to confirm these observations in an independent validation cohort.

Methods
Perioperative circulating levels of thrombospondin 1 were measured in patients undergoing liver resection between January 2012 and September 2013. Postoperative liver dysfunction was defined according to the International Study Group of Liver Surgery and classification of morbidity was based on the criteria by Dindo et al.

Results
In 85 patients (44 major and 41 minor liver resections), plasma levels of thrombospondin 1 increased 1 day after liver resection (mean 51·6 ng/ml before surgery and 68·3 ng/ml on postoperative day 1; P = 0·001). Circulating thrombospondin 1 concentration on the first postoperative day specifically predicted liver dysfunction (area under the receiver operating characteristic (ROC) curve 0·818, P = 0·003) and was confirmed as a significant predictor in multivariable analysis (Exp(B) 1·020, 95 per cent c.i. 1·005 to 1·035; P = 0·009). Patients with a high thrombospondin 1 concentration (over 80 ng/ml) on postoperative day 1 more frequently had postoperative liver dysfunction than those with a lower level (28 versus 2 per cent) and severe morbidity (44 versus 15 per cent), and their length of hospital stay was more than doubled (19·7 versus 9·9 days).

Conclusion
Thrombospondin 1 may prove a helpful clinical marker to predict postoperative liver dysfunction as early as postoperative day 1.
Information policy: Introduction
Authors: Loveday‐Chesley Brandi 
Published: April 2015

EDITOR'S SUMMARYThe ASIS&T Special Interest Group/Information Policy (SIG/IFP) analyzes local, national and global developments affecting multiple aspects of information access and use. This issue of the Bulletin explores trust, security and privacy, SIG/IFP's focus for the Association's 2014 Annual Meeting. The controversial and timely topic of net neutrality is examined from a historical perspective. Federal efforts in the area of cybersecurity and the practical implications of its failures are detailed. The importance of digital reader privacy is raised, comparing legal privacy assurances and gaps for brick and mortar libraries with security of readers' personal data in the cloud. A look at eHealth literacy reveals how the digital divide negatively affects health for various populations.
Questioning trust in the era of big (and small) data
Authors: Unsworth Kristene 
Published: April 2015

EDITOR'S SUMMARYInformation policy extends to our acknowledgements of website statements about data privacy and sharing, as we routinely check a box to gain access to a site. Users rarely give much thought to whether they can trust the site sponsor to protect personal information. While privacy is often the chief concern in discussions of gathering, storing and using information, trust in the sponsor, whether governmental or corporate, is crucial. Governing bodies recognize democracy, fairness and a right to information, covering both access and privacy, as part of a social and political contract. Yet with data being collected on a massive scale, legitimate concerns about data misuse can undermine our trust in such fundamental understandings, leaving transparency as a critical element. The ASIS&T Special Interest Group/Information Policy (SIG/IFP) will explore the issue of trust during a workshop at the 2014 Annual Meeting, considering its foundations and evolution and questioning its justification in the age of big data.
Mapping graphene science and development: Focused research with multiple application areas
Authors: Kay Luciano , Porter Alan L. , Youtie Jan , Rafols Ismael , Newman Nils 
Published: April 2015

EDITOR'S SUMMARYFocusing on graphene, a material made from carbon atoms, researchers constructed a map illustrating the material in the context of scientific developments and patent activity over time. Two basemaps reflecting general science and patent activity were created, in addition to two overlay maps reflecting scientific publication and patenting activities specific to graphene. The science and patent overlay maps together display how the material was discovered and used between 2000 and 2013. The maps reveal 222 Web of Science categories and 466 International Patent Classification categories and identify 18 macro‐disciplines and 35 macro‐patent categories. Graphene research is shown to focus on material sciences and closely related fields such as engineering and physical chemistry, while graphene inventions cover technologies from catalysis and semiconductors to the pharmaceutical arena. The node size, density of relationships and colors of the map give additional information on research and development efforts and relationships among subset topics. The process employed text mining, visualization and graphics software tools in addition to a mapping kit available from the authors.
Interstitial organizations as conversational bridges
Authors: Korff Valeska P. , Oberg Achim , Powell Walter W. 
Published: April 2015

EDITOR'S SUMMARYA novel approach to evaluating the impact of nonprofit organizations is proposed, combining social network and linguistic analysis. The authors examined data from nonprofit organizations' websites and site hyperlinks to other organizations. They identified 369 sites of organizations that measure social impact and captured inbound and outbound weblinks to construct a relational structure. Keywords from the sites were categorized as reflecting scientific, civil society or managerial domains and located the entity in a triangular semantic space. While most organizations fell into one of the three communities, some were in an interstitial space spanning these domains. The interstitial organizations used a mix of terminology, were densely interconnected and connected extensively to organizations across domains, but there were few direct connections among the three domains. The resulting map integrates cultural and relational dimensions and reveals hidden patterns and clusters. The approach can be used with other social systems combining rich text with relational data.
Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor‐positive metastatic breast cancer patients with exceptional responses to capecitabine
Authors: Levin Maren K. , Wang Kai , Yelensky Roman , Cao Ying , Ramos Corinne , Hoke Nicholas , Pippen John , Blum Joanne L. , Brooks Barry , Palmer Gary , Palma Norma , Balasubramanian Sohail , Ross Jeffrey S. , O'Shaughnessy Joyce 
Published: April 2015

AbstractWe analyzed the genomic and phosphoproteomic profiles of breast cancer tissue obtained from six patients with estrogen receptor (ER)‐positive, HER2‐negative metastatic breast cancer who had highly durable (≥5 years) and, in some cases, ongoing clinical responses with capecitabine. Formalin‐fixed, paraffin‐embedded tissue samples from patients' primary (n = 4) or metastatic (n = 2) breast cancers were utilized for targeted next‐generation sequencing and reversed phase protein microarray. Two patients received capecitabine monotherapy. Four patients received capecitabine in combination with paclitaxel; three of these continued single‐agent capecitabine after stopping paclitaxel. Capecitabine was discontinued for progressive disease after a mean of 66 months in four patients (range 54–86 months), and two patients remain on therapy, having received capecitabine for >91 months and >122 months, respectively. Three patients' cancers (50%) had likely functional alterations in DNA repair and chromatin remodeling genes, while three other patients' cancers had variants of unknown significance in these pathways. Mutations in PIK3CA, amplifications of FGFR1 or ZNF703, or phosphorylation of HER family receptors and their downstream proteins did not preclude exceptional responses to capecitabine. None of the patients' tumors harbored TP53 or PTEN mutations. Four of the patients had breast cancer tissue available for PTEN immunohistochemistry, and all four patients' cancers were positive for PTEN. These surprising findings in a group of phenotypically similar patients with ER‐positive, endocrine therapy‐pretreated, HER2‐negative metastases, are supported by preclinical data showing that sensitivity to 5‐fluorouracil is enhanced by deficiencies in chromatin remodeling and homologous recombination genes. Our findings suggest that mutations that inactivate homologous recombination and/or chromatin remodeling genes within ER‐positive, HER2‐negative breast cancers may predict for highly durable responses to capecitabine.
A Comprehensive Study of Formic Acid Oxidation on Palladium Nanocrystals with Different Types of Facets and Twin Defects
Authors: Choi Sang‐Il , Herron Jeffrey A. , Scaranto Jessica , Huang Hongwen , Wang Yi , Xia Xiaohu , Lv Tian , Park Jinho , Peng Hsin‐Chieh , Mavrikakis Manos , Xia Younan 
Published: April 2015

AbstractPalladium has been recognized as the best anodic, monometallic electrocatalyst for the formic acid oxidation (FAO) reaction in a direct formic acid fuel cell. Here we report a systematic study of FAO on a variety of Pd nanocrystals, including cubes, right bipyramids, octahedra, tetrahedra, decahedra, and icosahedra. These nanocrystals were synthesized with approximately the same size, but different types of facets and twin defects on their surfaces. Our measurements indicate that the Pd nanocrystals enclosed by {1 0 0} facets have higher specific activities than those enclosed by {1 1 1} facets, in agreement with prior observations for Pd single‐crystal substrates. If comparing nanocrystals predominantly enclosed by a specific type of facet, {1 0 0} or {1 1 1}, those with twin defects displayed greatly enhanced FAO activities compared to their single‐crystal counterparts. To rationalize these experimental results, we performed periodic, self‐consistent DFT calculations on model single‐crystal substrates of Pd, representing the active sites present in the nanocrystals used in the experiments. The calculation results suggest that the enhancement of FAO activity on defect regions, represented by Pd(2 1 1) sites, compared to the activity of both Pd(1 0 0) and Pd(1 1 1) surfaces, could be attributed to an increased flux through the HCOO‐mediated pathway rather than the COOH‐mediated pathway on Pd(2 1 1). Since COOH has been identified as a precursor to CO, a site‐poisoning species, a lower coverage of CO at the defect regions will lead to a higher activity for the corresponding nanocrystal catalysts, containing those defect regions.
Polyaniline‐Grafted VO(acac)2: An Effective Catalyst for the Synthesis of 2,5‐Diformylfuran from 5‐Hydroxymethylfurfural and Fructose
Authors: Xu Fenghua , Zhang Zehui 
Published: April 2015

AbstractHerein, polyaniline‐grafted vanadyl acetylacetonate [VO(acac)2] was prepared and used as an effective catalyst for the oxidation of 5‐hydroxymethylfurfural (HMF) under atmospheric oxygen pressure. A high HMF conversion of 99.2 % was obtained after 12 h at 110 °C, and 2,5‐diformylfuran (DFF) was obtained in 86.2 % yield. More importantly, the one‐pot conversion of fructose into DFF was also realized with two binary catalysts: Amberlyst‐15 and polyaniline–VO(acac)2. Amberlyst‐15 was used for the acid‐catalyzed dehydration of fructose into HMF, followed by the in situ oxidation of HMF catalyzed by polyaniline–VO(acac)2. DFF could be obtained in a yield of 42.1 % from fructose by using the one‐pot reaction, whereas two consecutive steps gave a higher DFF yield of 71.1 %. Owing to the facile catalyst preparation and low cost, this method showed a promising potential for the synthesis of DFF from abundant carbohydrates.
Torands Revisited: Metal Sequestration and Self‐Assembly of Cyclo‐2,9‐tris‐1,10‐phenanthroline Hexaaza Macrocycles
Authors: Schwab Matthias Georg , Takase Masayoshi , Mavrinsky Alexey , Pisula Wojciech , Feng Xinliang , Gámez José A. , Thiel Walter , Mali Kunal S. , de Feyter Steven , Müllen Klaus 
Published: April 2015

AbstractA series of novel toroidal cyclo‐2,9‐tris‐1,10‐phenanthroline macrocycles with an unusual hexaaza cavity are reported. Nickel‐mediated Yamamoto aryl–aryl coupling was found to be a versatile tool for the cyclotrimerization of functionalized 1,10‐phenathroline precursors. Due to the now improved processability, both liquid‐crystalline behavior in the bulk phase and two‐dimensional self‐assembly at the molecular level could be studied, for the first time, for a torand system. The macrocycles exhibited a strong affinity for the complexation of different metal cations, as evidenced by MALDI‐TOF analysis and spectroscopic methods. Experimental results were correlated to an extensive computational study of the cyclo‐2,9‐tris‐1,10‐phenanthroline cavity and its binding mode for metal cations. Due to the combination of several interesting features, toroidal macrocycles may find future applications in the field of ion and charge transport through molecular channels, as well as for chemical sensing and molecular writing in surface‐confined monolayers under STM conditions.