bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex
Authors: Varlı Mücahit , Kim Eunae , Oh Songjin , Pulat Sultan , Zhou Rui , Gamage Chathurika D. B. , Gökalsın Barış , Sesal Nüzhet Cenk , Kim Kyung Keun , Paik Man-Jeong , Kim Hangun 
Published: July 2024

Abstract
Background
Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and lymph nodes and is linked with poor prognosis and poor survival.

Methods
Here, we used in vitro and in silico methods to test the ability of chrysophanol, a molecule of natural origin, to suppress the progression of colorectal cancer by targeting the KITENIN/ErbB4 complex.

Results
Chrysophanol binds to ErbB4, disrupting the ErbB4/KITENIN complex and causing autophagic degradation of KITENIN. We demonstrated that chrysophanol binds to ErbB4 according to a molecular docking model. Chrysophanol reversed KITENIN-mediated effects on cell motility, aerobic glycolysis, and expression of downstream effector genes. Moreover, under conditions of KITENIN overexpression, chrysophanol suppressed the production of onco-metabolites.

Conclusion
Chrysophanol suppresses oncogenic activities by targeting the KITENIN/ErbB4 complex.

Graphical Abstract
Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer
Authors: Xu Zhijie , Zhou Zhiyang , Yang Xiaoxin , Thakur Abhimanyu , Han Ning , Li Hai-Tao , Li Liu-Gen , Hu Jun , Li Tong-fei , Yan Yuanliang 
Published: July 2024

AbstractPazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic activities against various human cancers. However, its clinical utility is limited by substantial side effects and therapeutic resistance. We developed a nanoplatform capable of delivering PAZ for enhanced anti-breast cancer therapy. Nanometer-sized PAZ@Fe-MOF, compared to free PAZ, demonstrated increased anti-tumor therapeutic activities in both syngeneic murine 4T1 and xenograft human MDA-MB-231 breast cancer models. High-throughput single-cell RNA sequencing (scRNAseq) revealed that PAZ@Fe-MOF significantly reduced pro-tumorigenic M2-like macrophage populations at tumor sites and suppressed M2-type signaling pathways, such as ATF6-TGFBR1-SMAD3, as well as chemokines including CCL17, CCL22, and CCL24. PAZ@Fe-MOF reprogramed the inhibitory immune microenvironment and curbed tumorigenicity by blocking the polarization of M2 phenotype macrophages. This platform offers a promising and new strategy for improving the cytotoxicity of PAZ against breast cancers. It provides a method to evaluate the immunological response of tumor cells to PAZ-mediated treatment.
TSP50 facilitates breast cancer stem cell-like properties maintenance and epithelial-mesenchymal transition via PI3K p110α mediated activation of AKT signaling pathway
Authors: Gao Feng , Liu Sichen , Wang Jing , Wei Gang , Yu Chunlei , Zheng Lihua , Sun Luguo , Wang Guannan , Sun Ying , Bao Yongli , Song Zhenbo 
Published: July 2024

Abstract
Background
Studies have confirmed that epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-like properties are conducive to cancer metastasis. In recent years, testes-specific protease 50 (TSP50) has been identified as a prognostic factor and is involved in tumorigenesis regulation. However, the role and molecular mechanisms of TSP50 in EMT and CSC-like properties maintenance remain unclear.

Methods
The expression and prognostic value of TSP50 in breast cancer were excavated from public databases and explored using bioinformatics analysis. Then the expression of TSP50 and related genes was further validated by quantitative RT-PCR (qRT-PCR), Western blot, and immunohistochemistry (IHC). In order to investigate the function of TSP50 in breast cancer, loss- and gain-of-function experiments were conducted, both in vitro and in vivo. Furthermore, immunofluorescence (IF) and immunoprecipitation (IP) assays were performed to explore the potential molecular mechanisms of TSP50. Finally, the correlation between the expression of TSP50 and related genes in breast cancer tissue microarray and clinicopathological characteristics was analyzed by IHC.

Results
TSP50 was negatively correlated with the prognosis of patients with breast cancer. TSP50 promoted CSC-like traits and EMT in both breast cancer cells and mouse xenograft tumor tissues. Additionally, inhibition of PI3K/AKT partly reversed TSP50-induced activation of CSC-like properties, EMT and tumorigenesis. Mechanistically, TSP50 and PI3K p85α regulatory subunit could competitively interact with the PI3K p110α catalytic subunit to promote p110α enzymatic activity, thereby activating the PI3K/AKT signaling pathway for CSC-like phenotypes maintenance and EMT promotion. Moreover, IHC analysis of human breast cancer specimens revealed that TSP50 expression was positively correlated with p-AKT and ALDH1 protein levels. Notably, breast cancer clinicopathological characteristics, such as patient survival time, tumor size, Ki67, pathologic stage, N stage, estrogen receptor (ER) and progesterone receptor (PR) levels, correlated well with TSP50/p-AKT/ALDH1 expression status.

Conclusion
The effects of TSP50 on EMT and CSC-like properties promotion were verified to be dependent on PI3K p110α. Together, our study revealed a novel mechanism by which TSP50 facilitates the progression of breast cancer, which can provide new insights into TSP50-based breast cancer treatment strategies.
Can central venous pressure help identify acute right ventricular dysfunction in mechanically ventilated critically ill patients?
Authors: Zhang Hongmin , Lian Hui , Zhang Qing , Zhao Hua , Wang Xiaoting 
Published: July 2024

Abstract
Objective
To investigate the relationship between central venous pressure (CVP) and acute right ventricular (RV) dysfunction in critically ill patients on mechanical ventilation.

Methods
This retrospective study enrolled mechanically ventilated critically ill who underwent transthoracic echocardiographic examination and CVP monitoring. Echocardiographic indices including tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and tricuspid lateral annular systolic velocity wave (S’) were collected to assess RV function. Patients were then classified into three groups based on their RV function and presence of systemic venous congestion as assessed by inferior vena cava diameter (IVCD) and hepatic vein (HV) Doppler: normal RV function (TAPSE ≥ 17 mm, FAC ≥ 35% and S’ ≥9.5 cm/sec), isolated RV dysfunction (TAPSE < 17 mm or FAC < 35% or S’ <9.5 cm/sec with IVCD ≤ 20 mm or HV S ≥ D), and RV dysfunction with congestion (TAPSE < 17 mm or FAC < 35% or S’ <9.5 cm/sec with IVCD > 20 mm and HV S < D).

Results
A total of 518 patients were enrolled in the study, of whom 301 were categorized in normal RV function group, 164 in isolated RV dysfunction group and 53 in RV dysfunction with congestion group. Receiver operating characteristic analysis revealed a good discriminative ability of CVP for identifying patients with RV dysfunction and congestion(AUC 0.839; 95% CI: 0.795–0.883; p < 0.001). The optimal CVP cutoff was 10 mm Hg, with sensitivity of 79.2%, specificity of 69.4%, negative predictive value of 96.7%, and positive predictive value of 22.8%. A large gray zone existed between 9 mm Hg and 12 mm Hg, encompassing 95 patients (18.3%). For identifying all patients with RV dysfunction, CVP demonstrated a lower discriminative ability (AUC 0.616; 95% CI: 0.567–0.665; p < 0.001). Additionally, the gray zone was even larger, ranging from 5 mm Hg to 12 mm Hg, and included 349 patients (67.4%).

Conclusions
CVP may be a helpful indicator of acute RV dysfunction patients with systemic venous congestion in mechanically ventilated critically ill, but its accuracy is limited. A CVP less than10 mm Hg can almost rule out RV dysfunction with congestion. In contrast, CVP should not be used to identify general RV dysfunction.
Perioperative fluid management for adult cardiac surgery: network meta-analysis pooling on twenty randomised controlled trials
Authors: Ma Yu-Tong , Xian-Yu Chen-Yang , Yu Yun-Xiang , Zhang Chao 
Published: July 2024

Abstract
Background
The aim of this study was to evaluate colloids and crystalloids used in perioperative fluid therapy for cardiac surgery patients to further investigate the optimal management strategies of different solutions.

Method
RCTs about adult surgical patients allocated to receive perioperative fluid therapy for electronic databases, including Ovid MEDLINE, EMBase, and Cochrane Central Register of Controlled Trials, were searched up to February 15, 2023.

Results
None of the results based on network comparisons, including mortality, transfuse PLA, postoperative chest tube output over the first 24 h following surgery, and length of hospital stay, were statistically significant. Due to the small number of included studies, the results, including acute kidney injury, serum creatinine, serum microglobulin, and blood urea nitrogen, are from the direct comparison. For transfusion of RBCs, significant differences were observed in the comparisons of 3% gelatine vs. 6% HES 200/0.5, 4% albumin vs. 5% albumin, 4% gelatine vs. 5% albumin, 5% albumin vs. 6% HES 200/0.5, and 6% HES 130/0.4 vs. 6% HES 200/0.5. In transfusion of FFP, significant differences were observed in comparisons of 3% gelatine vs. 4% gelatine, 3% gelatine vs. 6% HES 200/0.5, 5% albumin vs. 6% HES 200/0.5, 4% gelatine vs. 5% albumin, 4% gelatine vs. 6% HES 200/0.4, and 6% HES 130/0.4 vs. 6% HES 200/0.5. For urinary output at 24 h after surgery, the results are deposited in the main text.

Conclusion
This study showed that 3% gelatin and 5% albumin can reduce the transfuse RBC and FFP. In addition, the use of hypertonic saline solution can increase urine output, and 5% albumin and 6% HES can shorten the length of ICU stay. However, none of the perioperative fluids showed an objective advantage in various outcomes, including mortality, transfuse PLA, postoperative chest tube output over the first 24 h following surgery, and length of hospital stay. The reliable and sufficient evidences on the injury of the kidney, including acute kidney injury, serum creatinine, serum microglobulin, and blood urea nitrogen, was still lacking. In general, perioperative fluids had advantages and disadvantages, and there were no evidences to support the recommendation of the optimal perioperative fluid for cardiac surgery.
Landscape review about the decision to euthanize a compromised pig
Authors: Stoffregen J. , Winkelmann T. , Schneider B. , Gerdes K. , Miller M. , Reinmold J. , Kleinsorgen C. , Toelle K. H. , Kreienbrock L. , grosse Beilage E. 
Published: July 2024

AbstractTimely euthanasia of a compromised pig in farming practice has been identified as a critical topic in veterinary medicine. The questions ‘why and when are pigs euthanized’ and ‘what influences the decision making process’ need to be answered to improve the situation. In the past five years, work addressing these issues has been published in the literature, however, a synthesis of the findings is missing. With the help of a quantitative and qualitative analysis, this paper has generated a landscape review to outline major topics, the role of clinical signs and further influences on the decision to euthanize a pig. Due to the quantitative content analysis, 58 topics have been identified with the role ofwelfareas a justification andtrainingfor caretakers in making euthanasia decisions as the most frequently mentioned. The qualitative analysis of why and when a pig is euthanized generated a set of clinical signs for organ tracts, and a set of categories influencing the decision making process. The results outline the need to increase research on details specific to understanding how clinical signs evolve over time before euthanasia. In summary, the analysis provides an overview of work in the field and ideas on how to close knowledge gaps in the future. Moreover, the article contributes to harmonize efforts in the field and underlines the need for more research about the care of compromised and injured pigs.
The prevalence of medication-related problems in kidney transplant recipients at a tertiary care hospital in Saudi Arabia
Authors: Katlan Danyah , Hasan Hani , Aseeri Mohammed , Alsubhi Abrar , Ismail Sherin 
Published: July 2024

Abstract
Background
Limited data are available regarding the prevalence of medication-related problems (MRPs) in kidney transplant recipients. This study aimed to determine the prevalence and types of medication-related problems.

Methods
A cross-sectional study was conducted including kidney transplant recipients aged ≥ 18 years who were receiving immunosuppressive agents for at least 3 months post-transplant. The primary outcome was to determine the prevalence of MRPs. The secondary outcomes were to identify the pharmacological classes, categories of medications contributing to MRPs, and predictors of developing > 3 MRPs.

Results
We enrolled 107 kidney transplant recipients. The mean ± standard deviation (SD) of age and body mass index (BMI) were 50 ± 15.8 years and 28.9 ± 5.3 (kg/m2), respectively, and 66.3% were male. The prevalence of MRPs was 28.97% [95% confidence intervals (CI) 19.68%, 41.125] in 1393 prescriptions. The frequent types of MRPs were drug‒drug interactions (46.1%), duplication (12%), and medication use without an indication (11.7%). Immunosuppressive agents and cardiac medications were the main classes causing MRPs. The number of medications and the years post-kidney-transplant were significant predictors of developing > 3 MRPs.

Conclusion
The results showed that drug‒drug interactions were the most frequent MRPs, with immunosuppressive agents being the most common class causing MRPs.
Serum Medium-Chain Fatty Acids and the Risk of Incident Diabetes: Findings From the 4C Study
Authors: Jia Xiaojing , Lin Hong , Ding Yilan , Gu Xuejiang , Wang Shuangyuan , Xu Yu , Xu Min , Zhao Xinjie , Chen Lulu , Zeng Tianshu , Shi Lixin , Su Qing , Chen Yuhong , Yu Xuefeng , Yan Li , Qin Guijun , Wan Qin , Chen Gang , Tang Xulei , Gao Zhengnan , Shen Feixia , Hu Ruying , Luo Zuojie , Qin Yingfen , Chen Li , Hou Xinguo , Huo Yanan , Li Qiang , Wang Guixia , Zhang Yinfei , Liu Chao , Wang Youmin , Wu Shengli , Yang Tao , Deng Huacong , Zhao Jiajun , Mu Yiming , Ning Guang , Wang Weiqing , Bi Yufang , Lu Jieli 
Published: July 2024

Abstract

Context
Emerging studies have revealed associations between dietary medium-chain fatty acids (MCFAs) and glucose homeostasis. However, the relationship between serum MCFAs and the incidence of diabetes, and potential interactions with genetic predisposition, remains unclear in prospective cohort studies.

Objective
This work aimed to investigate associations and genetic susceptibility between serum MCFAs and diabetes risk.

Methods
We investigated baseline serum MCFAs (n = 5) in a nested case-control study comprising incident diabetes cases (n = 1707) and matched normoglycemic control individuals (n = 1707) from the China Cardiometabolic Disease and Cancer Cohort Study. Associations between MCFAs and type 2 diabetes mellitus (T2DM) were examined, both overall and stratified by diabetes genetic susceptibility. Genetic risk scores (GRS) were calculated based on 86 T2DM-associated genetic variants.

Results
In the fully adjusted conditional logistic regression model, serum octanoic acid and nonanoic acid exhibited inverse dose-response relationships with diabetes risk, showing odds ratios (95% CI) of 0.90 (0.82-0.98) and 0.84 (0.74-0.95), respectively. Subgroup analysis demonstrated that inverse associations between MCFAs and incident diabetes were more pronounced among individuals with physical inactivity (Pinteraction = .042, .034, and .037, for octanoic, nonanoic and decanoic acid, respectively). Moreover, inverse associations of octanoic acid with diabetes risk were notably enhanced among individuals with high genetic risk compared to those with low genetic risk. Statistically significant interactions were observed between octanoic acid and GRS on T2DM risk (Pinteraction = .003).

Conclusion
These findings provide evidence supporting inverse associations between serum MCFAs and T2DM risk, and reveal potential interplay between genetic susceptibility and circulating octanoic acid in modulating diabetes risk.
Extensive Cytomegalovirus Gastroduodenitis Causing Gastric Outlet Obstruction in an Immunocompetent Patient
Authors: Jalil Zunaira , Zaman Zubia , Lund Sundarta , Seetlani Naresh Kumar , Arshad Sidra 
Published: July 2024

ABSTRACT
Cytomegalovirus (CMV) has been extensively researched in immunocompromised people, causing conditions such as colitis, retinitis, esophagitis, encephalitis, and pneumonitis. However, there are limited data on how the disease presents itself in immunocompetent hosts, apart from a self-limited mononucleosis-like syndrome. This case report presents CMV gastroenteritis causing gastroduodenal obstruction in an immunocompetent woman. It is important to consider CMV as a potential cause of various gastric pathologies in immunocompetent people. Further research is necessary to establish guidelines for diagnosing and treating this pathogen.
A Real Gut Punch: An Unexpected Diagnosis of Spontaneous Splenic Rupture
Authors: Darnell Hannah , Bidarian Sara , Brenner Aaron , Auer Joseph 
Published: July 2024

ABSTRACT
Atraumatic or spontaneous splenic rupture is a rare but life-threatening complication of infectious mononucleosis. We present a case of a 26-year-old man presenting with a 1-week history of sharp epigastric and right upper quadrant pain, associated with malaise and subjective fever. Although initial findings were concerning for acute cholangitis, abdominal computed tomography angiography scan revealed splenic rupture. Further exploration confirmed acute Epstein-Barr virus infection. Infectious mononucleosis must be considered in young patients with lymphocytosis, splenomegaly, and prolonged malaise. Awareness of this presentation will allow for timely diagnosis and treatment, thereby preventing potentially fatal complications of infectious mononucleosis such as splenic rupture.
Social anthropology 4.0
Authors: Balthasar Mandy 
Published: July 2024

Abstract
Human-computer interaction as a coordinating element between human and machine is used in many different ways. Due to their digital processes, countless industries are dependent on an effective intermeshing of humans and machines. This often involves preparatory work or sub-processes being carried out by machines, which humans initiate, take up, continue, finalise or check. Tasks are broken down into sub-steps and completed by humans or machines. Aggregated cooperation conceals the numerous challenges of hybrid cooperation in which communication and coordination must be mastered in favour of joint decision-making. However, research into human-computer interaction can also be thought of differently than a mere aggregation of humans and machines. We want to propose a nature-inspired possibility that has been successfully practising the complex challenges of joint decision-making as proof of successful communication and coordination for millions of years. Collective intelligence and the processes of self-organisation offer biomimetic concepts that can be used to rethink socio-technical systems as a symbiosis in the form of a human-computer organism. For example, the effects of self-organisation such as emergence could be used to exceed the result of an aggregation of humans and machines as a future social anthropology 4.0 many times over.
Modifikasi Alat Ukur Patience in Islamic Psychology
Authors: Permanasari Chandra , Makayasa Garuda Suksesi Muhammad Adhi 
Published: July 2024

Penelitian ini bertujuan untuk memodifikasi alat ukur kesabaran yang dibuat oleh Rusdi (2016) sebagai variabel psikologis dalam perspektif Islam. Berdasarkan beberapa kajian literatur yang didapat, terdapat tiga dimensi kesabaran; kesabaran untuk melakukan ketaatan, kesabaran untuk menghindari larangan, dan kesabaran saat dalam penderitaan. Dimensi-dimensi tersebut diuji dengan kuesioner yang disebar melalui google form dengan sampel penelitian sebanyak 250 subjek dengan kriteria; mahasiswa aktif beragama Islam berusia 17-24 tahun. Penelitian ini menggunakan analisis reliabilitas Cronbach’s Alpha, Exploratory Factor Analysis (EFA), koefisien Kaiser-Meyer-Olkin (KMO), Confirmatory factor analysis (CFA) dengan Nilai reliabilitas Construct Reliability (CR), dan variance extracted (VE). Berdasarkan hasil modifikasi alat ukur kesabaran bisa dikatakan valid dan reliabel sehingga dapat dijadikan sebagai instrumen penelitian.
Perbedaan Self-Esteem antara Mahasiswa Perguruan Tinggi Negeri dengan Perguruan Tinggi Swasta
Authors: Salsabila Diana Fitria , Saffanah Qalbi Ananda Faza , Aziz Abdul Malik , Etniko Amoreyza , Tahir Rauf Khairun Nisa 
Published: July 2024

Peneliti melihat adanya penilaian yang berbeda terhadap perguruan tinggi negeri dan swasta, banyak dari masyarakat yang masih memandang rendah perguruan tinggi swasta. Penilaian tersebut dapat mempengaruhi self-esteem mahasiswa yang menempuh pendidikan pada perguruan tinggi tersebut. Penelitian bertujuan untuk mengetahui apakah terdapat perbedaan self-esteem pada mahasiswa Perguruan Tinggi Negeri dan Perguruan Tinggi Swasta. Penelitian dilakukan menggunakan metode kuantitatif dengan pendekatan komparatif. Adapun metode analisis statistik yang digunakan adalah uji t-test yang melibatkan 100 mahasiswa. Hasil penelitian menunjukkan tidak terdapat perbedaan self-esteem antara mahasiswa perguruan tinggi negeri dan swasta.
Fenomena Superiority Complex dan Narcissistic Terhadap Perilaku Individu di Sosial Media Dalam Perspektif Hadis
Authors: Nurazizah Syfa Aurela , Rohman Ujang , Ismail Shalahudin 
Published: July 2024

Penelitian ini bertujuan untuk memaparkan fenomena superiority complex dan narcissistic yang marak terjadi di media sosial dengan mempertimbangkan perspektif hadis dalam Islam. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kepustakaan, yaitu metodologis yang penelitian yang memusatkan perhatiannya pada data tertulis, seperti buku, jurnal, majalah, dan sumber-sumber lainnya. Hasil penelitian menunjukkan bahwa superiority complex merupakan gangguan psikologis, yaitu ketika individu merasa lebih baik dalam setiap aspek kehidupannya dibandingkan orang lain dan narcissistic merupakan gangguan kepribadian yang ditandai dengan perasaan haus akan pengakuan diri. Superiority complex dan narcissistic saling berkesinambungan satu sama lain dan media sosial adalah wadah bagi mereka yang memiliki gangguan tersebut untuk menujukan superioritas mereka dan menutupi sisi inferioritas yang ada.
Karakteristik Religiusitas pada Remaja dan Dewasa Awal
Authors: Fuadah Munatul , Sulianti Ambar , Al-Fatih Sultan Muhammad , Nurdin Indra 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui karakteristik religiusitas remaja dan dewasa awal juga berdasarkan gendernya. Jenis penelitian adalah penelitian kuantitatif cross-sectional study dengan analisis statistik Kruskal-Wallis. Subjek penelitian berjumlah 292 responden remaja dan dewasa awal, terdiri atas 47 laki-laki dan 245 perempuan. Hasil penelitian menunjukkan antara remaja dan dewasa awal cenderung memiliki karakteristik religiusitas yang relatif sama, hanya terdapat perbedaan pada pengetahuan keagamaan remaja yang lebih tinggi daripada dewasa awal, sedangkan dewasa awal memiliki karakteristik penghayatan yang lebih baik daripada remaja. Kesamaan karakteristik religiusitas ini juga dimiliki secara gender (laki-laki dan perempuan). Pada aspek keyakinan dan pengetahuan keagamaan, perempuan cenderung mengungguli dibandingkan laki-laki, namun laki-laki unggul pada aspek pengalaman.