bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kajian Adverse Drug Reactions Terkait Interaksi Obat pada Pasien Geriatrik di Salah Satu Rumah Sakit di Jayapura Periode Januari – April Tahun 2023
Authors: Risna  , Nago Pita Sari Nawang Wulan 
Published: July 2024

Study of adverse drug reactions related to drug interaction in geriatric patients at one of the hospitals in Jayapura from January to April 2023
Cases of therapeutic failure caused by drug interactions in the world are still quite high and one of the patients most vulnerable to drug interactions is geriatric patients due to the use of drug combinations. This study aims to identify the incidence of Adverse Drug Reactions (ADRs) related to drug interactions in inpatient geriatric patients at one of the hospitals in Jayapura. This research is descriptive-analytic in nature using a cross-sectional research design with a retrospective data collection technique using medical record data and prescription review for inpatient geriatric patients in January-April 2023. The sample in this study was 110 inpatient geriatric patients who met the specified criteria. The research results show that the incidence of ADRs related to drug interactions in inpatient geriatric patients in the January-April 2023 period was found to be 81 cases of drug interactions with a severity level of moderate 78% (63 cases), minor 13% (11 cases) and major 9% (7 case). Meanwhile, based on the results of the analysis of drug interaction mechanisms, it was found that pharmacodynamic interactions were 77% (62 cases) and pharmacokinetic interactions were 23% (19 cases). The potential for drug interactions in geriatric patients is still categorized as high. The high potential for drug interactions can have an impact on the pharmacological effects and side effects of the drug.
Kasus kegagalan terapi yang diakibatkan oleh interaksi obat di dunia masih cukup tinggi dan salah satu pasien yang paling rentan terhadap interaksi obat adalah pasien geriatrik akibat penggunaan kombinasi obat. Penelitian ini bertujuan untuk mengidentifikasi kejadian Adverse Drug Reaction (ADRs) terkait interaksi obat pada pasien geriatrik rawat inap di salah satu rumah sakit di Jayapura . Penelitian ini bersifat deskriptif analitik menggunakan desain penelitian cross sectional dengan teknik pengambilan data secara retrospektif menggunakan data rekam medik dan kajian resep pada pasien geriatrik rawat inap bulan Januari-April 2023. Sampel dalam penelitian ini sebanyak 110 pasien geriatrik rawat inap yang memenuhi kriteria yang ditetapkan. Hasil Penelitian menunjukkan bahwa kejadian ADRs terkait interaksi obat pada pasien geriatric rawat inap periode Januari-April Tahun 2023 ditemukan sebanyak 81 Kasus Interaksi Obat dengan tingkat keparahan Moderate 78% (63 kasus), minor 13% (11 kasus) dan major 9% (7 kasus). Sedangkan berdasarkan hasil analisis mekanime interaksi obat diperoleh interaksi farmakodinamik sebesar 77% (62 kasus) dan farmakokinetik sebesar 23% (19 kasus). Potensi kejadian interaksi obat pada pasien geriatrik masih dikategorikan tinggi. Tingginya potensi kejadian interaksi obat tersebut dapat berdampak pada efek farmakologi dan efek samping dari obat.
Penerapan Streching Untuk Meningkatkan Flexibilitas Pada Lansia Di Kelurahan Sudiang Wilayah Kecamatan Biringkanaya Kota Makassar
Authors: Awal Muhammad , Islam Fahrul , Thamrin Abdullah 
Published: July 2024

Penuaan adalah suatu proses menghilangnya secara perlahan-lahan kemampuan jaringan untuk memperbaiki kerusakan yang diderita. Proses menua merupakan proses yang terus-menerus berlanjut secara alamiah dimulai sejak lahir dan dialami oleh semua makhluk hidup. Tujuan dari pengabdian ini adalah untuk melihat aplikasi stretching pada lansia untuk meningkatkan flexibilitas otot di kelurahan sudiang Wilayah Kecamatan Biringkanaya Kota Makasaar.adapun hasil dari kegiatan ini adalah setelah di lakukan strecing pada alat gerak atas vertebra dan alat gerak bawah di hasilkan flexibilitas dapat di tingkatkan. Khalayak Sasaran adalah Lansia dan Masyarakat sekitar Sekolah, observasi jumlah lansia di kelurahan Sudiang wilayah Kecamatan Biringkanaya Kota makassar, Melaksanakan pemeriksaan fleksibilitas Lansia. Setelah terkumpul data Lansia kemudian melaksanakan pemeriksaan lansia, Menerapkan Stretching, Melakukan latihan Stretching pada Lansia. berdasarkan kategori flexibilitas yaitu baik 15 Orang (21,43%), cukup 50 Orang (71,43%) dan kurang 5 Orang (7,14%). Keberhasilan kegiatan di buktikan dengan antusia para lansia mengikuti kegiatan tersebut dan dari hasil pengukuran flexibilitas berada pada kategoro cukup dan baik

Kata Kunci : Stretching, Lansia, flexibilitas
STRATEGI MENANGGULANGI PERKAWINAN ANAK PADA MASYARAKAT PENERIMA PROGRAM KELUARGA HARAPAN DI GEDANGAN WIROSARI GROBOGAN JAWA TENGAH
Authors: Maskur Ali , Rismana Daud , Nisa' Khoirotin 
Published: July 2024

Perkawinan anak merupakan masalah yang tak berujung dan sulit diurai benang kusutnya. Peningkatan kasus paska UU No 16 Tahun 2019 dengan dinaikkannya usia perkawinan menjadi 19 tahun seperti bola salju yang terus menggelinding. Dispensasi perkawinan, hamil sebelum menikah, masalah ekonomi rumah tangga, kesehatan, pertengkaran dan berujung pada perceraian merupakan rangkaian dari perkawinan anak. Masalah ini mencapai puncaknya ketika perkawinan anak terjadi dilingkungan masyarakat penerima jaminan sosial berupa Program Keluarga Harapan (PKH) dari pemerintah yang bertujuan meningkatkan kesejahteraan masyarakat tertinggal. Justru perkawinan anak menjadi salah satu penghambat program tersebut.
Penelitian kualitatif dengan pendekatan deskriptif-analitik digunakan untuk menjawab permasalahan: 1. Mengapa perkawinan anak marak terjadi di lingkungan keluarga penerima Program Keluarga Harapan Dusun Sono Mbabar Gedangan Wirosari Grobogan Jawa Tengah ? 2. Sejauh mana tingkat pemahaman masyarakat Dusun Sono Mbabar Gedangan Wirosari Grobogan terhadap perubahan Undang-undang No 16 Tahun 2019 Tentang Batas Usia Perkawinan ? 3. Bagaimana strategi untuk mengurangi perkawinan anak di lingkungan keluarga penerima Program Keluarga Harapan ?
Temuan dari penelitian Pertama, Kompleksitas faktor pendorong perkawinan anak di lingkungan penerima jaring pengaman sosial Program Keluarga Harapan adalah rendahnya tingkat pendidikan yang maksimal tamat Sekolah Menengah Pertama. Pertanian menjadi mata pencaharian utama, minimnya akses informasi dan rendahnya literasi. Perkawinan menjadi alternatif penyelesaian masalah ketika jenjang pendidikan tidak ada, minimnya informasi dan ekonomi menjadi kebutuhan yang tidak bisa dielakkan. Kedua, perubahan Undang-undang No 16 Tahun 2019 jo Undang Undang Nomor 1 tahun 1974 tentang batasan usia perkawinan belum disosialisasikan secara massif. Keterkaitan antara bahaya ancaman perkawinan anak dengan kesehatan, pendidikan anak, kesiapan mental, pertengkaran dan perceraian tidak mendapat perhatian serius. Dispensasi nikah menjadi solusi dari pernikahan anak yang kerap terjadi. Ketiga, kerjasama antara Penyuluh Agama di Kantor Urusan Agama, Bidan Desa dan pendamping Program Keluarga Harapan dalam menyusun bahan penyuluhan secara bersama merupakan strategi yang diharapkan dapat menekan jumlah perkawinan anak.
Intersectional Analysis of Food Insecurity for 2S/LGBTQIA+ Communities in Canada and Implications for Dietetic Practice
Authors: Hou Sophia , White Megan , Ng Eric , Kelleher Sue , Gao Min , Joy Phillip 
Published: July 2024

The right to food is a fundamental human right, as established in international conventions and declarations. However, Canada has not explicitly protected the right to food in its Charter or National Food Policy. Food insecurity is a multifaceted issue requiring collaboration across different policy arenas and jurisdictions such as healthcare, housing, social assistance, and agriculture. For Two-Spirit, lesbian, gay, bisexual, transgender, queer, questioning, intersex, asexual, and other sexually and gender diverse (2S/LGBTQIA+) populations, intersecting forms of discrimination and barriers to health, including ingrained cisheteronormativity, must also be considered.
We approach the topic of food insecurity among 2S/LGBTQIA+ populations and the associated policy implications through the lens of Kimberle Crenshaw’s critical theory of intersectionality. Intersectionality theory recognizes that marginalized and polymarginalized groups experience discrimination along multiple axes. Policies which fail to recognize this serve to distort polymarginalized people’s lived experiences with issues such as food insecurity and may result in their legal and structural erasure.
We aim to peel back the layers of policies affecting 2S/LGBTQIA+ Canadians experiencing food insecurity to reveal points of intersection that may have been rendered functionally invisible. First, we will describe the current national policy context related to food security and 2S/LGBTQIA+ communities. Then, we will undertake a multi-axes analysis to attempt to illuminate the complex and multi-dimensional experiences of 2S/LGBTQIA+ populations living with food insecurity, using Nova Scotia as a regional case study example. We conclude by exploring the implications for dietetic practice across health and food systems in improving the health of 2S/LGBTQIA+ populations.
PERCEIVED EFFECTS OF CLIMATE CHANGE ON AGRICULTURAL PRODUCTIVITY IN IGBO-ETITI LOCAL GOVERNMENT AREA OF ENUGU STATE, NIGERIA
Authors: AKUKWE T.I. , MBA C.L. , ISIWU G.R. 
Published: July 2024

Climate change has been adduced to negatively affect agricultural productivity in agrarian communities. This study examined the effects of climate change on agricultural productivity in agrarian communities of Igbo-Etiti Local Government Area of Enugu State, Nigeria. Data were collected through the use of mixed and complementary methods such as observation, questionnaire survey and key informant interviews. The data generated were analyzed using descriptive statistics. Results reveal that majority (54.4%) of the respondents were female with farming the primary source of livelihood for majority (56.5%). Majority (59.1%) of the farmers were aged between 35 and 54 years, and majority (53%) had more than years farming experience. The results also revealed climate change as the major factor affecting agricultural productivity in the study area. The findings show that farmers in the study were highly vulnerable to the adverse effects of climate change largely because they depend on rain-fed agriculture. Agricultural productivity was found to have decreased due to the influence of climate change as manifested in rainfall decline, delayed onset of rain, increased temperature, dryness of soil and prolonged dry season. However, the reduced agricultural productivity had led to farmers engaging in other secondary occupation such as trading. Farmers empowerment through loans and grants, Climate Smart Agriculture, subsidies in the areas of improved climate change-resistant plants, among others were recommended to improve agricultural productivity, food security and cushion the effects of climate change, thereby enhancing resilience.
ANALISIS YURIDIS PERKARA PERCERAIAN NIKAH SIRI
Authors: Illahi Nur Wahyu , AKBAR MOCHAMMAD FAHD 
Published: July 2024

Perkara yang diangkat pada skripsi ini adalah terdapat pernikahan siri tetapi mengajukan gugatan perceraian di Pengadilan Agama. Hakim menggunakan pasal 7 ayat (3) huruf a KHI sebagai pertimbangan untuk mengisbathkan pernikahan tersebut. Penelitian ini melakukan analisis menurut hukum positif di Indonesia terhadap perkara nomor 7073/Pdt.G/2021/PA.Kab.Mlg tentang penggabungan isbath nikah dan perceraian. Metode penelitian yang digunakan adalah metode penelitian empiris dengan cara wawancara dan observasi di PA Kab. Malang dengan analisis data deskriptif, evaluatif dan preskriptif. Peneliti menganalisis putusan nomor 7073/Pdt.Kab.G/2021/PA.Mlg menggunakan Teori Etis hukum yang menunjukkan bahwa penggunaan pada pasal 7 (3) huruf (a) KHI dirasa memiliki kejanggalan terhadap penafsiran hukum jika disandingkan dengan peraturan perundang –undangan yang berlaku, meskipun begitu perkara ini tetaplah sah tetapi kepastian hukum dalam administrasi berperkara tidak dapat terwujud.
IMPACTOS DA EMENDA CONSTITUCIONAL Nº 95/2016 - TERCEIRIZAÇÃO NA UNIFAL-MG
Authors: Guimarães Lopes Charles , Roberto Guides Dennys , De Carvalho Eliane Cristina , Caríssimo Cláudio Roberto 
Published: July 2024

Este artigo analisou o impacto da Emenda Constitucional (EC) nº 95/2016 no orçamento financeiro da UNIFAL-MG, nas despesas de pessoal e de funcionamento da instituição, especificamente em relação à mão de obra terceirizada, fazendo uso de ferramentas da estatística descritiva. As crises financeiras e econômicas no Brasil, agravadas no período de 2015 a 2016, serviram de estímulo para o Governo Federal promulgar a EC nº 95/2016, colocando um teto de gastos sob a justificativa de condicionar o crescimento das despesas à variação anual do Índice de Preços Amplo ao Consumidor (IPCA). O presente estudo utilizou uma abordagem mista, quantitativa e qualitativa, utilizando as técnicas de coleta de dados documental e a de observador participante para analisar os efeitos da EC na terceirização da UNIFAL-MG. Os resultados evidenciam que o orçamento da instituição não foi reajustado sequer pelo índice oficial da inflação. Com isso, reduziu-se o quantitativo de colaboradores terceirizados e a verba destinada às atividades de ensino, de pesquisa e de extensão. Os achados do estudo destacam a importância de se analisar as consequências de mudanças políticas e orçamentárias nas IFES, sobretudo os efeitos em relação à necessidade de terceirização de serviços.
Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity
Authors: Machi Jacqueline F. , Altilio Isabella , Qi Yue , Morales Alejo A. , Silvestre Diego H. , Hernandez Diana R. , Da Costa-Santos Nicolas , Santana Aline G. , Neghabi Mehrnoosh , Nategh Parisa , Castro Thiago L. , Werneck-de-Castro João P. , Ranji Mahsa , Evangelista Fabiana S. , Vazquez-Padron Roberto I. , Bernal-Mizrachi Ernesto , Rodrigues Claudia O. 
Published: July 2024

Introduction: Obesity is a major risk factor associated with multiple pathological conditions including diabetes and cardiovascular disease. Endothelial dysfunction is an early predictor of obesity. However, little is known regarding how early endothelial changes trigger obesity. In the present work we report a novel endothelial-mediated mechanism essential for regulation of metabolic homeostasis, driven by c-Myc.Methods: We used conditional knockout (EC-Myc KO) and overexpression (EC-Myc OE) mouse models to investigate the endothelial-specific role of c-Myc in metabolic homeostasis during aging and high-fat diet exposure. Body weight and metabolic parameters were collected over time and tissue samples collected at endpoint for biochemical, pathology and RNA-sequencing analysis. Animals exposed to high-fat diet were also evaluated for cardiac dysfunction.Results: In the present study we demonstrate that EC-Myc KO triggers endothelial dysfunction, which precedes progressive increase in body weight during aging, under normal dietary conditions. At endpoint, EC-Myc KO animals showed significant increase in white adipose tissue mass relative to control littermates, which was associated with sex-specific changes in whole body metabolism and increase in systemic leptin. Overexpression of endothelial c-Myc attenuated diet-induced obesity and visceral fat accumulation and prevented the development of glucose intolerance and cardiac dysfunction. Transcriptome analysis of skeletal muscle suggests that the protective effects promoted by endothelial c-Myc overexpression are associated with the expression of genes known to increase weight loss, energy expenditure and glucose tolerance.Conclusion: Our results show a novel important role for endothelial c-Myc in regulating metabolic homeostasis and suggests its potential targeting in preventing obesity and associated complications such as diabetes type-2 and cardiovascular dysfunction.
The RNA chaperone Hfq has a multifaceted role in Edwardsiella ictaluri
Authors: Akgul Ali , Kalindamar Safak , Kordon Adef O. , Abdelhamed Hossam , Ibrahim Iman , Tekedar Hasan C. , Karsi Attila 
Published: July 2024

Edwardsiella ictaluri is a Gram-negative, facultative intracellular bacterium that causes enteric septicemia in catfish (ESC). The RNA chaperone Hfq (host factor for phage Qβ replication) facilitates gene regulation via small RNAs (sRNAs) in various pathogenic bacteria. Despite its significance in other bacterial species, the role of hfq in E. ictaluri remains unexplored. This study aimed to elucidate the role of hfq in E. ictaluri by creating an hfq mutant (EiΔhfq) through in-frame gene deletion and characterization. Our findings revealed that the Hfq protein is highly conserved within the genus Edwardsiella. The deletion of hfq resulted in a significantly reduced growth rate during the late exponential phase. Additionally, EiΔhfq displayed a diminished capacity for biofilm formation and exhibited increased motility. Under acidic and oxidative stress conditions, EiΔhfq demonstrated impaired growth, and we observed elevated hfq expression when subjected to in vitro and in vivo stress conditions. EiΔhfq exhibited reduced survival within catfish peritoneal macrophages, although it had no discernible effect on the adherence and invasion of epithelial cells. The infection model revealed that hfq is needed for bacterial persistence in catfish, and its absence caused significant virulence attenuation in catfish. Finally, the EiΔhfq vaccination completely protected catfish against subsequent EiWT infection. In summary, these results underscore the pivotal role of hfq in E. ictaluri, affecting its growth, motility, biofilm formation, stress response, and virulence in macrophages and within catfish host.
Scandinavian trade unions’ guidelines regarding nurses’ use of social media: a Fairclough-inspired critical discourse analysis
Authors: Glasdam Stinne , Xu Hongxuan , Gulestø Ragnhild Julante Andersen , Glasdam Selma , Stjernswärd Sigrid 
Published: July 2024

IntroductionSocial media provides nurses with tools to share information, debate healthcare policy and practice issues, and engage in interpersonal interactions. Historically, also in Scandinavia, nurses’ trade unions have taken the lead in defining nursing as a profession and supporting nurses in ‘conducting good nursing’. However, it is unexplored how trade unions guide nurses in social media use.AimTo explore the explicitly formulated guidance documents provided by Scandinavian nurses’ trade unions, specifically focusing on how the trade unions guided nurses’ social media use.Materials and methodsTrade union guidelines for social media use were searched on the Scandinavian nurses’ organisations’ websites. A textual discourse analysis inspired by Fairclough’s critical approach was conducted. The analysis considered three levels: the social practice level, focusing on connections between the texts and the surrounding society; the discursive practice level, focusing on the processes of production and distribution of the texts; and the textual level, capturing how grammatical formulations and single words work in the (re) construction of social structures.ResultsAt the social practice level, the trade union documents guiding nurses’ social media uses were embedded in platfomised public communication, laws about confidentiality and data protection, and ethical codes for nurses. At the discursive practice level, the guidelines were constructed to support nurses’ social media uses in adhering to their profession’s ethical principles. The trade unions’ implicit and explicit representations of nurses blurred the distinction between nurses as professionals and nurses as private persons. At the textual level, the guidelines tapped into the potential risks of using social media and how nurses ought to act on social media. Unlike the Danish and Swedish trade unions, the Norwegian trade union did not develop specific guidelines for nurses’ social media use.ConclusionThe guidelines emphasized risks stemming from social media use that did not adhere to the profession’s politically defined guidelines, norms, and values, although nurses’ conditions are already framed by the national legislations and ethical standards. The study advocates for the development of guidelines that support beneficial uses of social media in relation to nurses and the nursing profession.
Spatial distribution and source apportionment of soil heavy metals in the areas affected by non-ferrous metal slag field in southwest China
Authors: Jia Liang , Liang Huili , Fan Min , Guo Shushu , Yue Tingting , Wang Maosheng , Su Mingyue , Chen Shu , Wang Zhe , Fu Kaibin 
Published: July 2024

The spatial distribution and source analysis of heavy metals in soil are of great significance for the risk assessment and control of heavy metal pollution. Herein, a total of 87 topsoil samples (0–30 cm) were collected in the areas adjacent to a non-ferrous metal slag field of Gejiu City, Yunnan Province. The typical heavy metal concentrations, available phosphorus, available potassium, ammonium nitrogen, nitrate nitrogen, and pH in each soil sample were determined. Based on the above basic data, distribution and origins of heavy metals was analyzed. The results indicated that the mean contents of Pb, As, Cu, Zn, Ni and Cr in the topsoil of the study site were 247.82, 204.36, 104.83, 411.38, 29.73 and 67.59 mg kg-1, respectively. Exception of the Ni element, the contents of the remaining five heavy metals surpassed their respective background levels in study site. Especially, As element (with the highest accumulation effect) is 11.1l times of the background level, and the remaining four elements are 1.04–6.10 times of the background level in Yunnan. Single factor pollution index showed that the pollution degree of Pb, Cu and Zn was light, and the accumulation of As was a great threat to soil quality. Furthermore, the percentages of sites at mild pollution, moderate pollution and heavy pollution levels were 16.09%, 26.09% and 63.22%, respectively. Additionally, The order of potential ecological hazard degree of soil in the survey area was As &gt; Pb &gt; Cu = Ni &gt; Zn = Cr. The spatial dispersion of heavy metals within the study region is impacted by both natural phenomena and human activities. The areas with severe pollution were the mining area in the northwest and planting sites in the east, middle and south of the study area. The main contribution sources of Ni were the mixed sources of natural parent material and industrial activities. The heavy metal element largely contributed by industrial activities and transportation is Pb. The main sources of metals As, Cu and Zn are the integrated sources of agricultural and industrial activities. The main source of Cr is natural source. Therefore, these useful results can guide the heavy metal pollution control and restoration of study site and this research work can also be used to other similar metal slag field and its affected area.