bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimalisasi Desain Pembelajaran melalui Integrasi Augmented Intelligence: Sebuah Tinjauan Komprehensif dan Kerangka Kerja
Authors: Firnando Hero Gefthi 
Published: August 2024

Pada era teknologi pendidikan yang terus berkembang, integrasi Augmented Intelligence (AI) menjadi perhatian utama untuk optimalisasi desain pembelajaran. Penelitian ini bertujuan untuk memberikan tinjauan komprehensif dan menyajikan kerangka kerja yang memadukan kecerdasan buatan dengan kapabilitas manusia dalam konteks pembelajaran. Isu-isu utama yang dijelajahi melibatkan tantangan desain pembelajaran yang ada dan bagaimana AI dapat meningkatkan proses tersebut. Tujuan penelitian ini adalah untuk menganalisis dampak integrasi IA dalam desain pembelajaran, menyelidiki metode atau pendekatan yang efektif, dan menyusun kerangka kerja yang dapat memberikan pedoman praktis. Metode penelitian kualitatif digunakan dengan melakukan studi literatur mendalam dan analisis komprehensif terhadap implementasi dalam konteks pendidikan.Hasil penelitian menunjukkan bahwa integrasi AI dapat secara signifikan meningkatkan efektivitas desain pembelajaran dengan memberikan personalisasi, umpan balik real-time, dan adaptabilitas. Kerangka kerja yang diusulkan memberikan landasan bagi pengembangan lebih lanjut dalam mengoptimalkan desain pembelajaran melalui pemanfaatan kecerdasan buatan dan kemampuan manusia yang saling melengkapi. Implikasi praktis dan arah penelitian masa depan juga dibahas untuk memajukan pemahaman dan implementasi konsep AI dalam konteks pendidikan.
Pesan Islam Moderat Dalam Buku “Tuhan Ada Di Hatimu” Karya Habib Husain Ja’far Al Hadar
Authors: Yunus Nangim , Masruroh Sayidah Afyatul 
Published: August 2024

God's book is in your heart containing the views of various things from the beautiful Islamic point of view including the current conditions, all of that can be answered with the teachings of Islam as a religion that is timeless. Therefore, this research was carried out to identify any da'wah messages contained in it book God is in your heart conveying the various contents of the messages in it according to life's problems from various aspects through the da'wah it conveys so that it can be taken as research material in this thesis.
Until in this research the researchers formulated the research focus in this thesis, namely: (1) What is the message of moderate Islam contained in Habib Husain Ja'far al Hadar's book God Is in Your Heart. The theory used in this study is Content analysis for R Holsti, is a method for drawing conclusions by identifying the various special characteristics of a message objectively and systematically. The method used in this study is content analysis context analysis through a qualitative approach using descriptive analysis techniques. Analysis of the contents of the context of research analysis and intended fo examine the contents of the message and equate it in a communication during the da'wah messages in each paragraph which consists of four sub-titles of one book.
Based on the results of the data received is that the contents of God's book are in your heart, there are many messages of aqidah da'wah which contain teachings to believe in Allah and there are messages of moral preaching related to how we should behave towards fellow human beings, the da'wah messages in God's book are in your heart very relevant to everyday life because da'wah messages are packed with analogies that often occur in our daily lives.

Keyword: Moderate Islam, the book "God is in your heart, Habib Husain Ja'far Al Hadar.
Dampak Kualitas Produk, Pemasaran Digital, dan Harga terhadap Keputusan Pembelian Sepatu Ventela di Jabodetabek
Authors: Sriminarti Nurul , Arfan Muhammad 
Published: August 2024

The fashion industry in Indonesia continues to proliferate and can compete with imported products. One of them is a local shoe brand that is increasingly in demand by consumers. In business, product quality, marketing strategy, and price strongly appeal to consumers. The goal of this research is to test the impact of product quality, digital marketing, and price on purchasing decisions for Ventela shoes in the Jabodetabek area. By using a purposive sampling technique, the sample in this research was 210 respondents from Generation Z who were Ventela shoe users or had used Ventela shoes. The questionnaire was distributed via a Google form. Multiple linear regression was employed to analyze the model. The study's results document that product quality has a positive and significant effect on purchasing decisions. Digital marketing shows a positive and significant effect on purchasing decisions. Additionally, price has a positive and significant effect on purchasing decisions. The results of this study have implications for the Ventela shoe company, which needs to pay attention to product quality, product marketing strategies, and price so that consumer satisfaction is achieved and they recommend Ventela shoes to others.
Abstrak
Industri fashion di Indonesia terus berkembang pesat dan mampu bersaing dengan produk impor. Salah satunya adalah brand sepatu lokal yang semakin banyak diminati konsumen. Dalam bisnis, kualitas produk, strategi pemasaran, dan harga memiliki daya tarik yang kuat bagi konsumen. Tujuan dari penelitian ini adalah menguji dampak kualitas produk, pemasaran digital, dan harga pada keputusan pembelian sepatu Ventela di wilayah Jabodetabek. Dengan menggunakan teknik purposive sampling, sampel dalam penelitian ini sebanyak 210 responden dari generasi Z pengguna sepatu Ventela atau pernah menggunakan sepatu Ventela. Kuesioner disebarkan melalui Google form. Regresi linear berganda digunakan untuk mengalisis model. Hasil penelitian mendokumentasikan bahwa kualitas produk mempunyai pengaruh positif dan signifikan terhadap keputusan pembelian. Pemasaran digital menunjukkan pengaruh positif dan signifikan terhadap keputusan pembelian. Selain itu, harga berpengaruh positif dan signifikan terhadap keputusan pembelian. Hasil penelitian ini berimplikasi pada perusahaan sepatu Ventela untuk terus meningkatkan kualitas produk, strategi pemasaran produk, dan harga agar kepuasan konsumen tercapai dan mereka merekomendasikan sepatu Ventela kepada pihak lain.
Kata Kunci: Kualitas Produk, Pemasaran Digital, Harga, Keputusan Pembelian
Association between antibiotic usage during infancy and asthma incidence among children: a population-level ecological study in British Columbia, Canada
Authors: Mamun Abdullah Al , Zou Carl , Lishman Hannah , Stenlund Säde , Xie Max , Chuang Erica , Patrick David M. 
Published: August 2024

BackgroundThis study follows published associations in BC to 2014 (updated in 2019) to model the predicted incidence of asthma in BC children attributable to antibiotic use within the context of reduced antibiotic use and increased breastfeeding in BC infants from 2000 to 2019.MethodsA population-based ecological study was conducted in BC from 2000 to 2019, using outpatient antibiotic prescription data from BC PharmaNet and asthma diagnoses from the Chronic Disease Registry. Breastfeeding estimates were calculated using the Canadian Community Health Survey (CCHS). Population attributable risk (PAR) was calculated using a blended relative risk (RR) of asthma in antibiotic-exposed children who were and were not breastfed. PAR was used to calculate predicted vs. actual asthma incidence in 2019. Negative binomial regression was used to estimate the association between the average antibiotic prescription rate in infants under 1 and asthma incidence in 1–4 year olds, stratified by periods between 2000–2014 and 2015–2019.ResultsIn BC, antibiotic prescribing decreased by 77% in infants under 1 and asthma incidence decreased by 41% in children 1–4 years from 2000 to 2019. BC breastfeeding rates increased from 46% in the 2005 CCHS to 71% in the 2017/18 CCHS. After calculating the PAR using a blended RR, the predicted asthma incidence in 2019 was 18.8/1,000 population. This was comparable to the observed asthma incidence in children 1–4 years of 16.6/1,000 population in 2019. During 2000–2014, adjusted incidence risk ratio (aIRR) for children under Quintile 5 of average antibiotic prescribing was 1.75 (95% CI: 1.63–1.88, P &lt; 0.0001) times higher than that for Quintile 1. However, between 2015 and 2019, this association weakened (as expected because of increasing prevalence of breastfeeding), with the expected asthma incidence for Quintile 5 only 11% (aIRR 1.11, 95% CI: 0.78–1.57) higher than for Quintile 1.ConclusionWe identified that over the past 20 years, antibiotic exposure in infants under 1 and asthma incidence in children 1–4 years has decreased significantly. Decreasing antibiotic exposure and increasing breastfeeding (which further mitigates risk associated with antibiotics) are of sufficient scale to explain much of this population trend. Changes in environmental, social and other exposures remain relevant to this complicated etiological pathway.
Investigating the internal erosion behavior and microscopic mechanisms of chemically stabilized soil: an experimental study
Authors: Zhang Buping , Zhu Xinghua , Tao Xuewen , Wang Mengkui , Asghar Aamir , Mi Guoliang 
Published: August 2024

IntroductionInternal erosion triggered by water pipeline leaks seriously threatens the stability of the urban ground. Hangzhou, a city in Zhejiang Province, China, is facing critical challenges due to urban ground collapse (UGC) caused by internal erosion. However, there is a lack of research on the prevention of UGC by improving the internal erodibility of underground soil. Addressing this issue is of utmost importance to ensure the city’s stability and safety. This paper proposes to improve the internal erodibility of typical sandy silt soils with chemical stabilisers.MethodsThe effects of three chemical stabilisers, lignosulphonate (LS), lime (LI), and lignin fibre (LF), on the critical shear stress (τc) and erosion coefficient (kd) of sandy silt soils were investigated, which from Hangzhou, Zhejiang, China, by the hole erosion test (HET) at different mixing amounts and at different conservation times.ResultsThe findings indicate that LF mainly improves the erosion resistance of sandy silt by increasing τc, and the maximum increase is 2.38 times; LI mainly improves the erosion resistance by decreasing kd, and the maximum decrease is 2.18 times. After adding LS, τc and kd did not change significantly. The scanning electron microscope (SEM) test revealed that the inclusion of LF led to the formation of larger agglomerates in the sandy silt soil. The microstructure of sandy silt soil remained dispersed even after adding LS. Various chemical stabilisers used to improve sandy silt soils exhibited distinct erosion mechanisms. Sandy silt soils improved with LF exfoliated into agglomerates, displaying high resistance to erosion. On the other hand, the sandy silt treated with LF still lacks a protective layer and shows minimal improvements in its ability to withstand erosion. In contrast, the LS-amended sandy silt remains stripped with individual soil particles with insignificant changes in erosion resistance.DiscussionThis study can provide a conceptual framework for choosing foundation treatment techniques in future urban development projects.
Inflammatory factors and risk of lung adenocarcinoma: a Mendelian randomization study mediated by blood metabolites
Authors: Ding Zheng , Chen Juan , Li Bohan , Ji Xinyu 
Published: August 2024

BackgroundLung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis remains not fully elucidated. Inflammation and metabolic dysregulation are considered to play crucial roles in LUAD development, but their causal relationships and specific mechanisms remain unclear.MethodsThis study employed a two-sample Mendelian randomization (MR) approach to systematically evaluate the causal associations between 91 circulating inflammatory factors, 1,400 serum metabolites, and LUAD. We utilized LUAD genome-wide association studies (GWAS) data from the FinnGen biobank and GWAS data of metabolites and inflammatory factors from the GWAS catalog to conduct two-sample MR analyses. For the identified key metabolites, we further used mediator MR to investigate their mediating effects in the influence of IL-17A on LUAD and explored potential mechanisms through protein-protein interaction and functional enrichment analyses.ResultsThe MR analyses revealed that IL-17A (OR 0.78, 95%CI 0.62-0.99) was negatively associated with LUAD, while 71 metabolites were significantly associated with LUAD. Among them, ferulic acid 4-sulfate may play a crucial mediating role in the suppression of LUAD by IL-17A (OR 0.87, 95%CI 0.78-0.97). IL-17A may exert its anti-LUAD effects through extensive interactions with genes related to ferulic acid 4-sulfate metabolism (such as SULT1A1, CYP1A1, etc.), inhibiting oxidative stress and inflammatory responses, as well as downstream tumor-related pathways of ferulic acid 4-sulfate (such as MAPK, NF-κB, etc.).ConclusionThis study discovered causal associations between IL-17A, multiple serum metabolites, and LUAD occurrence, revealing the key role of inflammatory and metabolic dysregulation in LUAD pathogenesis. Our findings provide new evidence-based medical support for specific inflammatory factors and metabolites as early predictive and risk assessment biomarkers for LUAD, offering important clues for subsequent mechanistic studies and precision medicine applications.
Carbon dioxide electrochemical reduction by copper nanoparticles/ionic liquid-based catalytic inks
Authors: Gazzano Valeria , Mardones-Herrera Elías , Sáez-Pizarro Natalia , Armijo Francisco , Martinez-Rojas Francisco , Ruiz-León Domingo , Honores Jessica , Isaacs Mauricio 
Published: August 2024

The development of copper nanoparticle (CuNP)-based catalysts for the electrochemical reduction of carbon dioxide (ECO2-R) offers a promising approach to enhance its transformation into other industrially significant compounds. This study reports ECO2-R at −1.3 V vs RHE using CuNPs and catalytic inks composed of CuNPs and ionic liquids (ILs), observing significant differences in the selectivity of each catalyst. Specifically, CuNPs alone show a preference for producing ethylene and aqueous products, such as formic acid, ethanol, and formaldehyde. In contrast, the addition of ILs to the catalytic system redirects selectivity toward gaseous products, with methane being the main product. These findings highlight the potential to optimize catalyst composition to tailor the selectivity of CO2 conversion processes. ILs modify the catalytic environment and influence reaction pathways, enabling the selection of specific products.
Different polarization and functionality of CD4+ T helper subsets in people with post-COVID condition
Authors: Sánchez-Menéndez Clara , de la Calle-Jiménez Olivia , Mateos Elena , Vigón Lorena , Fuertes Daniel , Murciano Antón María Aranzazu , San José Esther , García-Gutiérrez Valentín , Cervero Miguel , Torres Montserrat , Coiras Mayte 
Published: August 2024

IntroductionAfter mild COVID-19 that does not require hospitalization, some individuals develop persistent symptoms that may worsen over time, producing a multisystemic condition termed Post-COVID condition (PCC). Among other disorders, PCC is characterized by persistent changes in the immune system that may not be solved several months after COVID-19 diagnosis.MethodsPeople with PCC were recruited to determine the distribution and functionality of CD4+ T helper (Th) subsets in comparison with individuals with mild, severe, and critical presentations of acute COVID-19 to evaluate their contribution as risk or protective factors for PCC.ResultsPeople with PCC showed low levels of Th1 cells, similar to individuals with severe and critical COVID-19, although these cells presented a higher capacity to express IFNγ in response to stimulation. Th2/Th1 correlation was negative in individuals with acute forms of COVID-19, but there was no significant Th2/Th1 correlation in people with PCC. Th2 cells from people with PCC presented high capacity to express IL-4 and IL-13, which are related to low ventilation and death associated with COVID-19. Levels of proinflammatory Th9 and Th17 subsets were significantly higher in people with PCC in comparison with acute COVID-19, being Th1/Th9 correlation negative in these individuals, which probably contributed to a more pro-inflammatory than antiviral scenario. Th17 cells from approximately 50% of individuals with PCC had no capacity to express IL-17A and IL-22, similar to individuals with critical COVID-19, which would prevent clearing extracellular pathogens. Th2/Th17 correlation was positive in people with PCC, which in the absence of negative Th1/Th2 correlation could also contribute to the proinflammatory state. Finally, Th22 cells from most individuals with PCC had no capacity to express IL-13 or IL-22, which could increase tendency to reinfections due to impaired epithelial regeneration.DiscussionPeople with PCC showed skewed polarization of CD4+ Th subsets with altered functionality that was more similar to individuals with severe and critical presentations of acute COVID-19 than to people who fully recovered from mild disease. New strategies aimed at reprogramming the immune response and redirecting CD4+ Th cell polarization may be necessary to reduce the proinflammatory environment characteristic of PCC.
An assessment of gynecological manifestations in women with female genital schistosomiasis with reference to Schistosoma biomarkers, sexually transmitted infections and bacterial vaginosis
Authors: Randrianasolo Bodo Sahondra , Jøker Karoline , Arenholt Louise Thomsen Schmidt , Rabozakandraina Tiana Onintsoa Oliva , Ramarokoto Charles Emile , Brønnum Dorthe , Jensen Martin , Christensen Søren Lundbye , Jensen Jørgen Skov , Corstjens Paul , van Dam Govert J. , Kobayashi Noriko , Hamano Shinjiro , Leutscher Peter Derek Christian 
Published: August 2024

BackgroundAlthough a variety of different gynecological manifestations have been reported in women with female genital schistosomiasis (FGS), causality remains to be established. This study aimed to evaluate the gynecological manifestations in women with FGS in accordance with the status of Schistosoma biomarkers, sexually transmitted infections (STIs), and bacterial vaginosis (BV).MethodsThe study was conducted in an endemic Schistosoma haematobium (Sh) area in northern Madagascar in conjunction with a randomized controlled trial investigating the effects and safety of a praziquantel repeated-dosing regimen for women with FGS-associated cervical lesions. Urogenital complaints, pelvic exam abnormalities, and cervical lesion types were assessed in relation to cervicovaginal Schistosoma DNA, circulating anodic antigen (CAA) in serum, and urinary Sh egg count, in addition to STIs and BV.ResultsAmong the included 116 women with a median of 26 years (range 15 to 35), the distribution of Schistosoma DNA and CAA outcomes, specified as either positive (+) or negative (-), were as follows: +/+ (18.1%), +/- (0%), -/+ (58.6%), and -/- (23.3%). Of the three Schistosoma biomarkers, only Schistosoma DNA and the urogenital complaint of blood in the urine were significantly associated. None of the biomarkers were significantly associated with pelvic exam abnormalities or cervical lesions. Sixty women (52.6%) were diagnosed with STIs and/or BV. A positive status was not significantly associated with any of the gynecological manifestations, except BV and homogeneous yellow sandy patches.ConclusionIt remains uncertain whether biomarkers such as cervicovaginal Schistosoma DNA, serum CAA, and Schistosoma eggs in urine adequately cover the full spectrum of gynecological manifestations reported in women with FGS, including urogenital complaints, pelvic exam abnormalities, and cervical lesions. Moreover, it seems difficult to determine the origin of the different manifestations due to the common co-existence of STIs and/or BV as potential confounders.
The effect of laparoscopic and abdominal surgery on the treatment of ectopic pregnancy: a systematic review and meta-analysis
Authors: Zhai Lin , Chen Yinping , Zhang Shengzhi 
Published: August 2024

ObjectiveThis study aimed to compare the efficacy of laparoscopic surgery (LS) and abdominal surgery (AS) in ectopic pregnancy surgery.MethodsA computer-based search was conducted in several databases such as CNKI, Wanfang data, VIP data, Chinese Biomedical Literature Database (CBM disc), PubMed, Cochrane Library, Embase, and others to gather domestic and foreign literature on treating ectopic pregnancy. This search was carried out from the inception of each database to July 2022. The literature review was performed using Endnote X9 software, and the data were analyzed using STATA 15.1 software for the meta-analysis.ResultsEight articles that met the inclusion criteria were included in the study. The meta-analysis showed that the laparoscopic group had shorter operation time than AS group [SMD = −1.28, 95%CI (−2.02, 0.54), p = 0.001], had less intraoperative bleeding [SMD = −3.06, 95%CI (−3.82, −2.31), p &lt; 0.01], shorter postoperative anus exhaust time [SMD = −2.60, 95%CI (−3.26, −1.93), p &lt; 0.01], and shorter hospital stay [SMD = −1.74, 95%CI (−2.09, −1.39), p &lt; 0.01] with few complications [RR = 0.22, 95%CI (0.08, 0.55), p = 0.001].ConclusionLS has more evident advantages in the treatment of patients with ectopic pregnancy. However, due to the lack of English literature that meets the inclusion criteria, further studies are needed to determine if LS has the same efficacy for European and American populations.
Antimicrobial resistance patterns in Streptococcus dysgalactiae in a One Health perspective
Authors: Glambek Marte , Skrede Steinar , Sivertsen Audun , Kittang Bård Reiakvam , Kaci Alba , Jonassen Christine Monceyron , Jørgensen Hannah Joan ,   Norwegian Study Group on Streptococcus dysgalactiae, Oppegaard Oddvar 
Published: August 2024

BackgroundStreptococcus dysgalactiae (SD) is an important pathogen in humans as well as in a broad range of animal species. Escalating rates of antibiotic resistance in SD has been reported in both human and veterinary clinical practice, but the dissemination of resistance determinants has so far never been examined in a One Health Perspective. We wanted to explore the occurrence of zoonotic transmission of SD and the potential for exchange of resistance traits between SD from different host populations.MethodsWe compared whole genome sequences and phenotypical antimicrobial susceptibility of 407 SD isolates, comprising all isolates obtained from human bloodstream infections in 2018 (n = 274) and available isolates associated with animal infections from the years 2018 and 2019 (n = 133) in Norway.ResultsAntimicrobial resistance genes were detected in 70 (26%), 9 (25%) and 2 (2%) of the isolates derived from humans, companion animals and livestock, respectively. Notably, distinct host associated genotypic resistomes were observed. The erm(A) gene was the dominant cause of erythromycin resistance in human associated isolates, whereas only erm(B) and lsa(C) were identified in SD isolates from animals. Moreover, the tetracycline resistance gene tet(O) was located on different mobile genetic elements in SD from humans and animals. Evidence of niche specialization was also evident in the phylogenetic analysis, as the isolates could be almost perfectly delineated in accordance with host species. Nevertheless, near identical mobile genetic elements were observed in four isolates from different host species including one human, implying potential transmission of antibiotic resistance between different environments.ConclusionWe found a phylogenetic delineation of SD strains in line with host adapted populations and niche specialization. Direct transmission of strains or genetic elements carrying resistance genes between SD from different ecological niches appears to be rare in our geographical region.