bluuebunny/crossref_metadata_2025_split huggingface dataset:
Export Experience of Managers and the Internationalisation of Firms
Authors: Sala Davide , Yalcin Erdal 
Published: September 2014

AbstractAs the firm gravitates toward being the core in analyses of international trade, the possibilities for learning from cross‐disciplines studies increase. Managerial resources underlie export initiation in the theory of the multinational enterprise developed in international business studies, but they are largely ignored in empirical studies of international trade. This is probably not because they are unimportant, but more due to the challenges of identifying and measuring these resources. We exploit Danish employer–employee matched data to overcome this challenge and analyse the impact of managers' international experience, together with other managerial characteristics, on the likelihood that the firm starts exporting. We find that productivity and fixed costs associated with exporting are not the sole determinants of selection of firms into international markets, but that ‘managerial inputs’ are just as important. Our data allow us to identify manager export experience based on the CEO's historical career as documented in official registry statistics, a feature that makes our analysis different from other work that relies on self‐assessments.
Genome Sequence of Rickettsia tamurae, a Recently Detected Human Pathogen in Japan
Authors: Sentausa Erwin , El Karkouri Khalid , Michelle Caroline , Caputo Aurelia , Raoult Didier , Fournier Pierre-Edouard 
Published: September 2014

ABSTRACT

Rickettsia tamurae
is a member of the spotted fever group rickettsiae, which was reported in 2011 to cause human infections in Japan. We report the draft genome sequence of
R. tamurae
strain AT-1
T
, isolated from
Amblyomma testudinarium
ticks.
Genome Sequences of Corynebacterium pseudotuberculosis Strains 48252 (Human, Pneumonia), CS_10 (Lab Strain), Ft_2193/67 (Goat, Pus), and CCUG 27541
Authors: Håvelsrud Othilde Elise , Sørum Henning , Gaustad Peter 
Published: September 2014

ABSTRACT

Here we report the genome sequencess of four
Corynebacterium pseudotuberculosis
strains. These include a strain isolated from a patient with
C. pseudotuberculosis
pneumonia (48252), a strain isolated from pus in goat (Ft_2193/67), a laboratory strain originating from strain Ft_2193/67 (CS_10), and the draft genome of an equine reference strain, CCUG 27541.
Draft Genome Sequence of a Sulfide-Oxidizing, Autotrophic Filamentous Anoxygenic Phototrophic Bacterium,
Chloroflexus
sp. Strain MS-G (
Chloroflexi
)
Authors: Thiel Vera , Hamilton Trinity L. , Tomsho Lynn P. , Burhans Richard , Gay Scott E. , Schuster Stephan C. , Ward David M. , Bryant Donald A. 
Published: September 2014

ABSTRACT

The draft genome sequence of the thermophilic filamentous anoxygenic phototrophic bacterium
Chloroflexus
sp. strain MS-G (
Chloroflexi
), isolated from Mushroom Spring (Yellowstone National Park, WY, USA) was sequenced and comprises 4,784,183 bp in 251 contigs. The draft genome is predicted to encode 4,059 protein coding genes, 49 tRNA encoding genes, and 3 rRNA operons.
Draft Genome Sequence of
Pseudomonas
sp. Strain JMM, a Sediment-Hosted Environmental Isolate
Authors: Grewal Simmi , Vakhlu Jyoti , Gupta Vipin , Sangwan Naseer , Kohli Puneet , Nayyar Namita , Rani Pooja , Sance Shivani Singh , Lal Rup 
Published: September 2014

ABSTRACT

Pseudomonas
sp. strain JMM was isolated from the sediments of a natural water reservoir (pH, 6 to 7) located at Chambyal village in Samba district of Jammu and Kashmir, India. Here we report the annotated draft genome sequence of strain JMM having 52 contigs with 5,884 genes and an average G+C content of 66.5%.
Draft Genome Sequences of Ralstonia pickettii Strains SSH4 and CW2, Isolated from Space Equipment
Authors: Monsieurs Pieter , Mijnendonckx Kristel , Provoost Ann , Venkateswaran Kasthuri , Ott C. Mark , Leys Natalie , Van Houdt Rob 
Published: September 2014

ABSTRACT

Ralstonia pickettii
SSH4 and CW2 were isolated from space equipment. Here, we report their draft genome sequences with the aim of gaining insight into their potential to adapt to these environments.
The morphological and immunohistochemical spectrum of gastric biopsies of patients with absorptive hypercalciuria
Authors: Declich Paolo , Belloni Jacopo , Tavani Enrico , Omazzi Barbara , Bellone Stefano , Bortoli Aurora , Arena Ilaria , Devani Massimo 
Published: September 2014

ObjectiveIdiopathic hypercalciuria is characterised by renal stone formation and vertebral osteoporosis. The syndrome displays high clinical variability with patients almost equally distributed between fasting or renal type (prevalent calcium loss) and absorptive type (prevalent increase of intestinal absorption). Absorptive hypercalciuria (AH) is characterised by hypersensitivity of calcium-sensing receptors of antral G cells with normal fasting gastrinaemia and meal hypergastrinaemia. To the best of our knowledge, no study has been published about the morphological aspects of gastric biopsies of patients with AH and the immunohistochemical findings of gastrin-producing G cells. So we studied morphologically and immunohistochemically a group of 38 patients with AH, describing their gastric findings and associated lesion.DesignAll 38 patients had a clinical-laboratory diagnosis of AH with normal fasting hypergastrinaemia and an abnormal rise of gastrinaemia after a standardised meal test. Their 38 antral and 27 body-fundus biopsies, and 5 normal antral and body controls, were stained with H&E, Giemsa stain, polyclonal antiserum anti-Gastrin and a monoclonal antibody anti-Chromogranin A.ResultsAntral biopsies of all 38 patients showed a simple (15) or linear (23) hyperplasia of G cells, whereas only 2 of 27 body biopsies showed a nodular hyperplasia of endocrine cells. In five patients with AH, we found an association with fundic gland polyps (FGPs).ConclusionsWe found in all of the patients with AH a correlation between meal hypergastrinaemia and morphological antral G-cell hyperplasia. Moreover, in five patients, AH was associated with FGPs. We know from literature data that FGPs’ development in Zollinger-Ellison syndrome is statistically associated with hypergastrinaemia. From our present data, we suggest that even in AH the stimulated hypergastrinaemia may have a role in polyp development.
Safety and efficacy of long-term nasobiliary drainage to treat intractable pruritus in cholestatic liver disease
Authors: Appleby V J , Hutchinson J M , Davies M H 
Published: September 2014

IntroductionCholestasis related pruritus, secondary to intrahepatic and/or extrahepatic biliary obstruction is a common manifestation in chronic liver disease. Pruritus is difficult to treat, and results are often suboptimal. A stepwise medical approach is usually employed, followed by a trial molecular adsorbents recirculation system in medication resistant cases. Pruritus resulting in reduced quality of life is a variant syndrome eligible for liver transplantation in the setting of preserved synthetic function.AimThis case series describes the use of long-term (LT) nasobiliary drainage (NBD) in three patients with intractable pruritus. This case series tests the hypothesis that LT-NBD could be successfully used to alleviate cholestasis related pruritus, and prevent or delay the need for liver transplantation.MethodLT-NBD was carried out in three female patients (mean age 43 years) with intractable pruritus secondary to primary biliary cirrhosis (PBC) (n=2), and benign recurrent intrahepatic cholestasis (n=1). NBD was carried out through the endoscopic placement of a 6 French Cook Medical nasobiliary catheter into the common bile duct.ResultsSymptomatic relief of pruritus was described by all three cases within 24 h of NBD placement. LT-NBD was stopped in the patient with benign recurrent intrahepatic cholestasis after 8 weeks due to complete resolution of pruritus. In one patient with PBC, LT-NBD was undertaken over 12 months, with complete resolution of pruritus. In the second patient with PBC, LT-NBD was carried out over 14 months, with complete resolution of pruritus.DiscussionThis case series supports the efficacy of LT-NBD in the treatment of intractable pruritus. We propose that NBD offers an accessible modality for the treatment of intractable pruritus in liver disease, potentially avoiding the need for liver transplantation.
Reach for gold
Authors: Vogel Tobias , Heise Arvid , Draisbach Uwe , Lange Dustin , Naumann Felix 
Published: September 2014

Duplicates in a database are one of the prime causes of poor data quality and are at the same time among the most difficult data quality problems to alleviate. To detect and remove such duplicates, many commercial and academic products and methods have been developed. The evaluation of such systems is usually in need of pre-classified results. Such gold standards are often expensive to come by (much manual classification is necessary), not representative (too small or too synthetic), and proprietary and thus preclude repetition (company-internal data). This lament has been uttered in many papers and even more paper reviews.The proposedannealing standardis a structured set of duplicate detection results, some of which are manually verified and some of which are merely validated by many classifiers. As more and more classifiers are evaluated against the annealing standard, more and more results are verified and validation becomes more and more confident. We formally define gold, silver, and the annealing standard and their maintenance. Experiments show how quickly an annealing standard converges to a gold standard. Finally, we provide an annealing standard for 750,000 CDs to the duplicate detection community.
Compositional verification of a medical device system
Authors: Murugesan Anitha , Whalen Michael W. , Rayadurgam Sanjai , Heimdahl Mats P.E. 
Published: September 2014

Complex systems are by necessity hierarchically organized. Decomposition into subsystems allows for intellectual control, as well as enabling different subsystems to be created by distinct teams. This decomposition affects both requirements and architecture. The architecture describes the structure and this affects how requirements ``flow down'' to each subsystem. Moreover, discoveries in the design process may affect the requirements. Demonstrating that a complex system satisfies its requirements when the subsystems are composed is a challenging problem.
In this paper, we present a medical device case example where we apply an iterative approach to architecture and verification based on software architectural models. We represent the hierarchical composition of the system in the Architecture Analysis and Design Language (AADL), and use an extension to the AADL language to describe the requirements at different levels of abstraction for compositional verification. The component-level behavior for the model is described in Simulink/Stateflow. We assemble proofs of system level properties by using the Simulink Design Verifier to establish component-level properties and an open-source plug-in for the OSATE AADL environment to perform the compositional verification of the architecture. This combination of verification tools allows us to iteratively explore design and verification of detailed behavioral models, and to scale formal analysis to large software systems.
A framework to schedule parametric dataflow applications on many-core platforms
Authors: Bebelis Vagelis , Fradet Pascal , Girault Alain 
Published: September 2014

Dataflow models, such as SDF, have been effectively used to program streaming applications while ensuring their liveness and boundedness. Yet, industrials are struggling to design the next generation of high definition video applications using these models. Such applications demand new features such as parameters to express dynamic input/output rate and topology modifications. Their implementation on modern many-core platforms is a major challenge.
We tackle these problems by proposing a generic and flexible framework to schedule streaming applications designed in a parametric dataflow model of computation. We generate parallel as soon as possible (ASAP) schedules targeted to the new STHORM many-core platform of STMicroelectronics. Furthermore, these schedules can be customized using user-defined ordering and resource constraints.
The parametric dataflow graph is associated with generic or user-defined specific constraints aimed at minimizing timing, buffer sizes, power consumption, or other criteria. The scheduling algorithm executes with minimal overhead and can be adapted to different scheduling policies just by adding some constraints. The safety of both the dataflow graph and constraints can be checked statically and all schedules are guaranteed to be bounded and deadlock free. We illustrate the scheduling capabilities of our approach using a real world application: the VC-1 video decoder for high definition video streaming.
Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Authors: Dayekh Khalil , Johnson-Obaseki Stephanie , Corsten Martin , Villeneuve Patrick J. , Sekhon Harmanjatinder S. , Weberpals Johanne I. , Dimitroulakos Jim 
Published: September 2014

Abstract
Targeting the EGFR, with inhibitors such as erlotinib, represents a promising therapeutic option in advanced head and neck squamous cell carcinomas (HNSCC). However, they lack significant efficacy as single agents. Recently, we identified the ability of statins to induce synergistic cytotoxicity in HNSCC cells through targeting the activation and trafficking of the EGFR. However, in a phase I trial of rosuvastatin and erlotinib, statin-induced muscle pathology limited the usefulness of this approach. To overcome these toxicity limitations, we sought to uncover other potential combinations using a 1,200 compound screen of FDA-approved drugs. We identified monensin, a coccidial antibiotic, as synergistically enhancing the cytotoxicity of erlotinib in two cell line models of HNSCC, SCC9 and SCC25. Monensin treatment mimicked the inhibitory effects of statins on EGFR activation and downstream signaling. RNA-seq analysis of monensin-treated SCC25 cells demonstrated a wide array of cholesterol and lipid synthesis genes upregulated by this treatment similar to statin treatment. However, this pattern was not recapitulated in SCC9 cells as monensin specifically induced the expression of activation of transcription factor (ATF) 3, a key regulator of statin-induced apoptosis. This differential response was also demonstrated in monensin-treated ex vivo surgical tissues in which HMG-CoA reductase expression and ATF3 were either not induced, induced singly, or both induced together in a cohort of 10 patient samples, including four HNSCC. These results suggest the potential clinical utility of combining monensin with erlotinib in patients with HNSCC. Mol Cancer Ther; 13(11); 2559–71. ©2014 AACR.
Contribuição de grupos de atividades de terapia ocupacional na evolução de pessoas com diagnóstico de esquizofrenia refratária usuárias de clozapina
Authors: Cirineu Cleber Tiago , Miasso Adriana Inocenti , Assad Francine Baltazar , Pedrão Luiz Jorge 
Published: September 2014

A esquizofrenia é um transtorno mental e a utilização de estratégias que combinam tratamento com psicofármacos e psicossocial aumentam as chances de seu controle. O objetivo deste estudo foi avaliar a evolução de pessoas com diagnóstico de esquizofrenia refratária, medicadas com clozapina, participantes de grupos de atividades de terapia ocupacional. Pesquisa exploratória de caráter quantitativo com participação de oito pessoas com diagnóstico de esquizofrenia refratária, medicadas com clozapina, pertencentes a um Grupo de pacientes em uso de Antipsicóticos avaliados pela Escala de Observação Interativa de Terapia Ocupacional. Os resultados, avaliados estatisticamente, mostraram que o grupo de atividades permitiu um suporte à prática das habilidades sociais e estimulação da exploração de idéias e sentimentos, visto que pessoas com diagnóstico de transtorno mental apresentam comprometimento em seu desempenho ocupacional. A aplicabilidade da escala mostrou-se adequada, visto que possibilitou avaliar as intervenções terapêuticas ocupacionais junto ao tratamento farmacológico e sua importância no processo de reabilitação psicossocial.
Papéis ocupacionais de mulheres que fazem uso abusivo de substâncias psicoativas
Authors: Soares Larissa Cecília Oliveira , Ruzzi-Pereira Andrea , Pereira Paulo Estevão , Cavalcanti Alessandra , Andrade Valéria Sousa de 
Published: September 2014

O uso de substâncias psicoativas é uma prática milenar e universal, não sendo, portanto, um fenômeno exclusivo da atualidade. A história do uso destas substâncias se mescla a própria história da humanidade; seu consumo sempre aconteceu ao longo dos tempos, em todas as religiões e culturas, com finalidades específicas. O individuo que faz uso abusivo de drogas tende a assumir a drogadição como atividade principal em seu cotidiano, negligenciando, na maioria das vezes, os papéis que realizava anteriormente. O objetivo deste estudo é descrever e analisar o impacto do uso de drogas nos papéis ocupacionais de mulheres que faziam uso abusivo de substâncias psicoativas. Estudo de natureza quantitativa em que foi utilizada a Lista de Identificação de Papéis Ocupacionais para coletar os dados. Os sujeitos da pesquisa constituíram-se de vinte e uma mulheres internadas em uma instituição para tratamento de mulheres com problemas relacionados ao abuso de drogas, no período de abril a maio de 2011, quando se deu a coleta de dados. Aponta-se como dado relevante a alta percentagem de mulheres que abandonaram o exercício de papéis ocupacionais em decorrência do uso abusivo das SPA e, diante disso a importância da inserção do terapeuta ocupacional nas equipes que compõem os serviços que atendem esta população.
Caracterização do uso de atividades físicas em crianças e adolescentes com anemia falciforme
Authors: Segava Nayara Bernardes , Cavalcanti Alessandra , De Paula Fernanda Godoi , Mendes Edmar Lacerda 
Published: September 2014

Das anemias hereditárias, a falciforme (AF) configura-se como a anemia hemolítica do tipo autossômica recessiva mais prevalente no mundo, determinada por uma alteração da hemoglobina que não consegue transpor-se pelos vasos e fazendo com o que o sistema circulatório apresente difi culdades para levar a oxigenação ao organismo. Visto que na literatura brasileira têm-se ponderações apenas em relação à descrição da prática de atividade física por indivíduos com o traço falciforme, este estudo buscou investigar e pontuar considerações referentes ao desempenho ocupacional de crianças/adolescentes com AF para a realização de atividades físicas. Foi realizado um estudo de natureza qualitativa exploratória e como procedimento de delineamento o estudo de caso, os dados foram coletados utilizando-se a Medida Canadense de Desempenho Ocupacional com 13 sujeitos, crianças/adolescentes com o diagnóstico de AF. Foram constatadas alterações obtidas no desempenho das crianças/adolescentes com AF no que diz respeito às atividades físicas, como a indisposição,cansaço, dor, edema. Contudo, verificou-se que tais acometimentos não são compreensíveis para esta população, e que existem distintos graus de limitação.
Endothelial Shear Stress and Coronary Plaque Characteristics in Humans
Authors: Vergallo Rocco , Papafaklis Michail I. , Yonetsu Taishi , Bourantas Christos V. , Andreou Ioannis , Wang Zhao , Fujimoto James G. , McNulty Iris , Lee Hang , Biasucci Luigi M. , Crea Filippo , Feldman Charles L. , Michalis Lampros K. , Stone Peter H. , Jang Ik-Kyung 
Published: September 2014

Background—
Despite the exposure of the entire vasculature to the atherogenic effects of systemic risk factors, atherosclerotic plaques preferentially develop at sites with disturbed flow. This study aimed at exploring in vivo the relationship between local endothelial shear stress (ESS) and coronary plaque characteristics in humans using computational fluid dynamics and frequency-domain optical coherence tomography.

Methods and Results—

Three-dimensional coronary artery reconstruction was performed in 21 patients (24 arteries) presenting with acute coronary syndrome using frequency-domain optical coherence tomography and coronary angiography. Each coronary artery was divided into sequential 3-mm segments and analyzed for the assessment of local ESS and plaque characteristics. A total of 146 nonculprit segments were evaluated. Compared with segments with higher ESS [≥1 Pascal (Pa)], those with low ESS (<1 Pa) showed higher prevalence of lipid-rich plaques (37.5% versus 20.0%;
P
=0.019) and thin-cap fibroatheroma (12.5% versus 2.0%;
P
=0.037). Overall, lipid plaques in segments with low ESS had thinner fibrous cap (115 μm [63–166] versus 170 μm [107–219];
P
=0.004) and higher macrophage density (normalized standard deviation: 8.4% [4.8–12.6] versus 6.2% [4.2–8.8];
P
=0.017). Segments with low ESS showed more superficial calcifications (minimum calcification depth: 93 μm [50–140] versus 152 μm [105–258];
P
=0.049) and tended to have higher prevalence of spotty calcifications (26.0% versus 12.0%;
P
=0.076).

Conclusions—
Coronary regions exposed to low ESS are associated with larger lipid burden, thinner fibrous cap, and higher prevalence of thin-cap fibroatheroma in humans. Frequency-domain optical coherence tomography–based assessment of ESS and wall characteristics may be useful in identifying vulnerable coronary regions.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01110538.
Clinical Correlates of Infarct Shape and Volume in Lacunar Strokes
Authors: Asdaghi Negar , Pearce Lesly A. , Nakajima Makoto , Field Thalia S. , Bazan Carlos , Cermeno Franco , McClure Leslie A. , Anderson David C. , Hart Robert G. , Benavente Oscar R. 
Published: September 2014

Background and Purpose—
Infarct size and location are thought to correlate with different mechanisms of lacunar infarcts. We examined the relationship between the size and shape of lacunar infarcts and vascular risk factors and outcomes.

Methods—
We studied 1679 participants in the Secondary Prevention of Small Subcortical Stroke trial with a lacunar infarct visualized on diffusion-weighted imaging. Infarct volume was measured planimetrically, and shape was classified based on visual analysis after 3-dimensional reconstruction of axial MRI slices.

Results—

Infarct shape was ovoid/spheroid in 63%, slab in 12%, stick in 7%, and multicomponent in 17%. Median infarct volume was smallest in ovoid/spheroid relative to other shapes: 0.46, 0.65, 0.54, and 0.90 mL, respectively (
P
<0.001). Distributions of vascular risk factors were similar across the 4 groups except that patients in the ovoid/spheroid and stick groups were more often diabetic and those with multicomponent had significantly higher blood pressure at study entry. Intracranial stenosis did not differ among groups (
P
=0.2). Infarct volume was not associated with vascular risk factors. Increased volume was associated with worse functional status at baseline and 3 months. Overall, 162 recurrent strokes occurred during an average of 3.4 years of follow-up with no difference in recurrent ischemic stroke rate by shape or volume.

Conclusions—
In patients with recent lacunar stroke, vascular risk factor profile was similar among the different infarct shapes and sizes. Infarct size correlated with worse short-term functional outcome. Neither shape nor volume was predictive of stroke recurrence.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00059306.