bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proinflammatory interleukins 2, 6 and tumor necrosis factor alpha in patients with hypertension and diabetes mellitus depending on the presence of metabolic-associated liver steatosis
Authors: Radchenko O.M. , Komarytsia O.J. , Borovets M.O. , Ivasivka R.S. , Guta R.R. 
Published: June 2024

Background. Lack of information about proinflammatory interleukins (IL) and tumor necrosis factor alpha (TNFα) levels in case of metabolic-associated liver steatosis (MALS) and their roles in its progression to steatohepatitis are key reasons for the relevance and actuality of our study. The purpose: to evaluate proinflammatory interleukins 2, 6, and TNFα levels in concomitant liver steatosis. Materials and methods. Thirty-five patients with hypertension stage II–III, type 2 diabetes mellitus were examined. All of them were treated on an outpatient basis according to the guidelines of the Ministry of Health of Ukraine and the Declaration of Helsinki. Participants were divided into the main group with MALS (n = 24, males 45.8 %, females 54.2 %; average age 55.83 ± 0.89 years) and the control group without steatosis (n = 11, males 54.5 %, females 45.5 %; average age 53.00 ± 1.55 years). In addition to standard parameters, levels of IL6, IL2, TNFα, selectin, resistin, insulin, C-peptide, glycated hemoglobin, non-esterified fatty acids were evaluated, and some indexes were calculated, including triglyceride-glucose index and Castelli indexes I and II. Results were processed statistically, with significance level of р < 0.05. Results. Although MALS is not followed by qualitative differences in proinflammatory IL2, IL6 and TNFα compared to no steatosis, the risk of TNFα elevation was 5 times higher in patients with MALS (odds ratio 5.08; 95% confidence interval 1.02–25.17). An increase in IL2 and TNFα is unfavorable for patients with MALS, it can be considered as a marker of steatosis progression to steatohepatitis, as it is associated with transaminase activation, endogenous intoxication, lipid distress and glucose intolerance. IL6 was rather lower in patients with MALS compared to those without steatosis, but its growth was exponential and proceeded simultaneously to IL2 and TNFα. Conclusions. MALS was not associated with significant changes in IL2, IL6 and TNFα compared to no steatosis, but their elevation can be criteria for transformation into steatohepatitis due to the activation of transaminases, inflammation, endogenous intoxication, lipid distress, glucose intolerance.
Elevating Sugarcane Farming: Effects of Certified Seed Adoption on Production and Income in East Java, Indonesia
Authors: Sandita Tia , Rachmina Dwi , Tinaprilla Netti 
Published: July 2024

The use of certified seed is essential for sugarcane agricultural intensification method, emphasizing input quality improvements. In this context, varietal validity has the potential to increase sugarcane output volumes and ensure quality variations. Therefore, this research aimed to analyze the variables affecting farmers' decisions on seed varieties, output, and revenue. The type of data used was cross-sectional with a sample of 1,763 respondents, consisting of 303 and 1,460 adopter and non-adopter farmers, respectively. Propensity score matching and logistic regression were the analysis methods used. The results showed that farmers' age, number of workers, land ownership status, extension participation, and partnerships significantly influenced the decisions in selecting seed types. Significant variations in output, gross income, total expenses, net income, and net earnings were also reported using statistical test analysis, with certified seed adopters having higher profits. In this context, young farmers should be targeted to promote the use of certified seed, provide sufficient labor support for intensive farming, ease access to land, and enhance persuasive messages about partnership benefits. Moreover, ensuring the continuity of production and distribution was important to maintain reasonable seed prices and facilitate farmers' access.
Student Preferences in the Milk Market
Authors: Bórawski Piotr , Grzybowska-Brzezińska Mariola 
Published: June 2024

The article presents consumer preferences on the milk market. The research was conducted on a group of 98 students studying management at the Higher School of Economics and Social Sciences in Ostrołęka in 2014. The research showed that the respondents are young and they pay the greatest attention to: quality, brand and price. The respondents buy milk every day or several times a week. The students ranked ease of purchase, product quality, and wide choice of products as the most important factors in their decision to buy a particular milk from a particular vendor. They also indicated the most important information on a container was the percentage of fat and the expiration date.
A meta-analysis of effectiveness of mobile health interventions on health-related outcomes in patients with heart failure
Authors: Zhang Jingwen , Nie Xiaofei , Yang Xiaoli , Mei Qian , Xiang Xiancheng , Cheng Li 
Published: July 2024

Aims
To systematically evaluate the effectiveness of mobile health (mHealth) interventions on medication adherence in patients with heart failure.

Methods
The literature search was conducted in PubMed, Web of Science, the Cochrane Library databases, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database and China Scientific Journal Database (VIP). The retrieval period was from the establishment of the database to May 2023. The included studies were trials to explore the effectiveness of mHealth interventions on medication adherence in patients with heart failure. Cochrane collaboration's tool was used for assessing risk of bias in randomized controlled trials. Stata 17.0 software was used to conduct data analysis. Continuous data were expressed as standard mean differences, and dichotomous data were expressed as relative risks with 95% confidence intervals (CIs).

Results
A total of 13 studies and 2534 participants were included. One study was rated as Grade A, and the other 12 studies were Grade B. The results of meta-analysis indicate that mHealth interventions are effective in improving medication adherence [relative risk (RR) = 1.26, 95% CI 1.10–1.44, P < 0.05 and standard mean difference = 0.80, 95% CI 0.44–1.15, P < 0.05], and reducing readmission rates (RR = 0.63, 95% CI 0.53–0.76, P < 0.05) and mortality (RR = 0.63, 95% CI 0.43–0.94, P < 0.05) of patients with heart failure.

Conclusion
mHealth interventions are beneficial to improve medication adherence in patients with heart failure, and could effectively reduce the readmission rates and mortality of patients in the studies. There is a need to continuously improve the professional abilities of intervention personnel, carry out teamwork, and extend intervention and follow-up time. Convenient, fast and low-cost mobile medical devices should be adopted to reduce the cost of medical treatment. Scientific and reasonable intervention content will be formulated according to evidence-based guidelines and theoretical basis to enhance patients’ ability at self-management and understanding of heart failure knowledge.
Loop-mediated isothermal amplification polymerase chain reaction in place of a modified Knott test in screening dogs for heartworm (Dirofilaria immitis) infection combined with antigen detection test
Authors: Cho Jaechun , Jeong Soo-Yeon , Kim Min-Suk , Cho Wang Sik , Kim Dong-Wook , Park Chul 
Published: June 2024

Abstract

OBJECTIVE
To improve the current recommendations for the diagnosis of canine heartworm (Dirofilaria immitis) disease.

ANIMALS
Blood samples collected from 35 shelter dogs in the Republic of Korea.

METHODS
Samples were tested for the presence of microfilaria using the modified Knott (MK) test and D immitis DNA using species-specific loop-mediated isothermal amplification (LAMP) PCR. The blood samples were additionally assessed for the presence of heartworm antigens using the Antigen Rapid Canine Heartworm AG Test Kit 2.0 (Bionote Co). The performance of the MK test and LAMP PCR was assessed through statistical analysis, with a paired McNemar test utilized for comparison.

RESULTS
The heartworm antigen was detected in 28.5% of the subjects. Of the 10 positive animals, the MK test detected microfilaria in 4 of 35 (11.4%) animals, and LAMP PCR detected D immitis DNA in 6 of 35 (17.1%). The results of this study indicate that the LAMP PCR showed more positive results in samples compared to the conventional MK test.

CLINICAL RELEVANCE
The D immitis–specific LAMP PCR assay has the potential to function as an alternative to current detection methods. It could complement the existing antigen detection tests in diagnosing canine heartworm infections.
The use of soapy water and freezing as secondary steps for euthanasia in cave (Blaberus giganteus) and Madagascar hissing (Gromphadorhina portentosa) cockroaches
Authors: Barnes Summer , Sadar Miranda J. , Hausmann Jennifer , Mama Khursheed 
Published: June 2024

Abstract

OBJECTIVE
To evaluate methods for euthanizing cave cockroaches (CCs; Blaberus giganteus) and Madagascar hissing cockroaches (MHCs; Gromphadorhina portentosa). It was hypothesized that both suggested methods would be effective for humane mass euthanasia of both species.

SAMPLE
Approximately 800 CC.

METHODS
The CCs were separated into replicate groups of 25, 50, 75, 100, and 150 grams and placed into 3.8-L plastic bags. Twenty-seven MHCs were divided into groups of 2 to 3. The study took place from January to March 2023. All CC groups were exposed to 100% carbon dioxide (CO2) at a rate of 4 L/min until the bag was full. Madagascar hissing cockroaches were similarly anesthetized using either CO2 or 2 mL of isoflurane on a cotton ball in a 1-L container or a combination of CO2 and isoflurane. Once cockroaches were immobile, secondary euthanasia steps were performed. One bag of CCs per weight category was exposed to soapy water (5% Dawn dishwashing liquid), and the second was placed into a −80 °C freezer. The containers of MHCs were evenly exposed to the 2 euthanasia methods. Individuals remained in their secondary euthanasia method for 30 minutes.

RESULTS
Regardless of the weight of the CCs within each bag, there was no impact on time (1.8 ± 0.4 minutes [mean ± SD]) to immobility. The failure rates for both species were 0.2% CI (−0.1% to 1.5% [1/413]) for soapy water and 0.5% CI (0.005% to 1.9% [2/414]) for the freezer method. These results support the use of both 2-step euthanasia methods in CCs and MHCs.

CLINICAL RELEVANCE
These methods will serve as an evidence-based alternative for humane mass euthanasia in cockroaches.
Погребение золотоордынского времени с бревенчатой оградой на левобережье Нижнего Днестра
Authors: Круглов Евгений Викторович , Синика Виталий Степанович 
Published: June 2024

В 2014 г. на левобережье Нижнего Днестра были исследованы четыре кургана группы «Спутник». Основное погребение кургана № 2 было окружено на древнем горизонте бревенчатой конструкцией типа ограды. Захоронение было полностью ограблено. Дата, предложенная в 2015 г. для этого кургана, опиралась на формальное сходство данной ограды с деревянными конструкциями из курганов у с. Буторы, окружавших скифские могилы IV в. до н.э. Полученные позже (в 2023 г.) радиоуглеродные даты бревен и костей лошади указали на связь памятника с эпохой Золотой Орды. Это потребовало переосмысления материалов и поиск иных аналогий. Было установлено, что железный ременной распределитель из грабительской траншеи относится к предметам аскизского типа и должен связываться не с грабителями, а с разрушенным основным захоронением знатного воина-всадника второй половины XIII – XIV в. Аналогии бревенчатой конструкции, окружавшей данное погребение, ранее были выявлены на Нижнем Днепре и в Поволжье. Материалы кургана № 2 расширили границы распространения памятников с бревенчатыми оградами на западные районы Улуса Джучи. Опыт радиоуглеродного датирования позволил исправить ошибки традиционного датирования. Он показал, что данный метод может успешно использоваться в исследовании памятников археологии эпохи средневековья.
Резная геометрическая плетёнка из раскопок крымского медресе Инджи-бей Хатун
Authors: Кирилко Владимир Петрович 
Published: June 2024

При археологическом изучении медресе в г. Старый Крым (бывш. Эски Кырым, Крым, Солхат), датируемого 733 г.х. (= 1332/33 гг.), были найдены многочисленные архитектурные детали с резным эпиграфическим орнаментом, часть которых вторично использовалась в кладке подпорной стены некрополя XVI–XVIII вв. По мнению специалистов, они могли принадлежать декоративному убранству портала, михраба в южном айване, восточной стены здания или входной экседры. Исследованием установлено, что ни одно из этих предположений пока не имеет достаточно убедительного подтверждения. Определён важный признак, позволяющий правильно понять орнаментальную композицию, а, следовательно, осуществить корректную реконструкцию каменной пластики медресе. Им является обязательное наличие значительной по площади гладкой поверхности, примыкающей к рельефному бордюру с внутренней стороны. В частности, поэтому принадлежность найденных архитектурных деталей порталу и михрабу здания маловероятна.
Бронзовые и железные браслеты Барбашинского могильника из раскопок А.С. Башкирова в 1921 году
Authors: Глазистова Наталья Ивановна 
Published: June 2024

Барбашинский могильник на территории г. Самара – крупнейший мордовский некрополь золотоордынского периода в Самарском Заволжье. В 1921 г. профессор Самарского университета А.С. Башкиров исследовал не менее 71 погребения на памятнике, которые содержали богатый инвентарь, в том числе бронзовые и железные браслеты. В статье представлены результаты типологического анализа браслетов из раскопок А.С. Башкирова, хранящихся в фондах СОИКМ им. П.В. Алабина, предпринята попытка их систематизации и рассмотрения в контексте золотоордынских древностей Самарского Заволжья и других регионов. В общей сложности изучено 42 бронзовых и 2 железных браслета из женских комплексов (40 экз.), детских погребений (2 экз.), парного и неатрибутированного захоронений (по 1 экз.) Большая часть браслетов – дротовые (23 экз.), среди которых выделяются остроконечные, браслеты с расплющенными лопатковидными концами и тупоконечные, в т.ч. «змеиноголовые». Пластинчатые браслеты (14 экз.) богато декорированы сочетанием нескольких видов орнамента – мелким зигзагом, пуансонным орнаментом, розетками, рельефными полосками, насечками. Бронзовые витые (5 экз.) и железные браслеты (2 экз.) немногочисленны. В статье рассматриваются некоторые аспекты технологического производства бронзовых браслетов, характер орнамента и особенности его нанесения для различных типов браслетов в коллекции. Все браслеты находят широкие аналогии на синхронных памятниках Золотой Орды и Руси.
Specjalni jeńcy w specjalnym obozie – dowództwo Armii Krajowej w Oflagu IV C Colditz
Authors: Stanek Piotr 
Published: June 2024

Tematem artykułu jest pobyt w niewoli niemieckiej, w Oflagu IV C Colditz, kierowniczej grupy Armii Krajowej z Dowódcą AK gen. dyw. Tadeuszem Komorowskim „Borem” na czele, liczącej w sumie 20 osób. Przetrzymywani tam byli od 5 lutego do 13 kwietnia 1945 r. W tym obozie, uchodzącym za obóz specjalny lub karny, w pierwszych latach wojny przetrzymywano polskich oficerów z kampanii 1939 r., następnie głównie anglosaskich jeńców, w tym jeńców specjalnych. Dotychczas uwagę badaczy skupiała głównie szczególna aktywność osadzonych w zakresie spektakularnych ucieczek, a pobyt generalskiej grupy AK nie był przedmiotem szerszej analizy badaczy. Najczęściej pobyt w obozach jenieckich grupy gen. „Bora” był po prostu odnotowany, na poziomie kronikarskim, a nie poglębionego opisu – jak wyglądała ta niewola.
Análisis comparativo de las agendas ciudadanas y mediáticas en Ecuador durante el primer año de mandato del presidente Guillermo Lasso.
Authors: Carrasco-Hermida Sebastian 
Published: June 2024

Ecuador es un país que, en los últimos quince años, se ha caracterizado por una polarización política. En este contexto, este estudio realiza un análisis de la correspondencia entre la agenda pública y la agenda mediática, tanto de medios tradicionales impresos como de medios digitales independientes, en Ecuador, durante el primer año de gobierno del presidente Guillermo Lasso (24 de mayo de 2021- 23 de mayo de 2022). Se recuperaron datos de agenda pública obtenidos por la encuestadora Click Research, avalada por el Consejo Nacional Electoral para realizar encuestas de opinión pública, y se realizó un análisis de contenido temático de las principales noticias de cuatro medios de comunicación ecuatorianos, tanto digitales (Primicias y Radio La Calle) como tradicionales (El Comercio y El Universo). Se aplicó el índice de equiparación de agendas propuesto por Asp para analizar hasta qué punto se corresponden las agendas de los medios con la agenda pública. Los resultados demuestran que existe una correspondencia entre las agendas de los diferentes tipos de medios y la agenda pública, existiendo mayor equiparación de agendas con los medios tradicionales impresos, para temas más permanentes de agenda; y mayor equiparación de agenda con los medios digitales independientes, para temas inmediatos relacionados con acontecimientos coyunturales y específicos.
Clinico-epidemiological characteristics and long-term surgical outcome of basal cell carcinoma treated with standard excision in patients of skin of colour: A retrospective study from Northern India
Authors: Vinay Keshavamurthy , Mehta Hitaishi , Chatterjee Debajyoti , Reddy Ashwini , Jain Sejal , Narang Tarun , Dogra Sunil 
Published: June 2024

Background
There is scant data on basal cell carcinoma (BCC) in Indian patients. This retrospective study was conducted to explore epidemiology, risk factors, clinical and pathological aspects, and long-term treatment outcomes of BCC in a cohort of North Indian patients.

Methods
Data about patients registered in the dermatosurgery clinic between 01 January 2017 and 31 December 2022 with a confirmed diagnosis of BCC was collected.

Results
Among the 83 patients, 56.6% were females, and the median age was 62 years (6–85 years). Most patients (81.9%) had a single BCC lesion, resulting in a total of 126 assessed lesions. The median size of BCC at presentation was 1.90 cm, with nodular BCC being the most common histopathological subtype (39.7%). Head and neck region involvement was observed in 82.5% of patients, with the malar region, nose, and periorbital region being the most commonly affected sites. Pigmentation was clinically evident in 45.2% of cases. Surgical excision was the primary treatment modality (71.1% of patients). The median follow-up duration was 40 months (6–57 months). Recurrence occurred in five patients, with a longer disease-free survival period observed in the surgically treated group (55.58 ± 0.98 months) compared to patients treated with medical or destructive therapies (43.6 ± 3.482 months) (p = 0.003).

Conclusion
The data from this hospital-based study indicated a slight predilection for females among North Indian patients with BCC, with most cases occurring during their seventh decade of life. The condition commonly occurred on sun-exposed areas such as the malar region and nose, with a high percentage of pigmented lesions. Recurrence following surgical excision was rare, and overall treatment outcomes were favourable.
An extremely rare case of primary alveolar rhabdomyosarcoma in the central nervous system
Authors: Nishikawa Masahiro , Inoue Akihiro , Moritani Kyoko , Kagajo Mari , Kitazawa Riko , Kunieda Takeharu 
Published: June 2024

Background:
Alveolar rhabdomyosarcoma (ARMS) shows a predilection for the peripheral extremities and is very rarely identified as a primary in the brain. Here, we report a case of ARMS with multiple lesions exclusively within the central nervous system (CNS).

Case Description:
A 20-year-old man presented to our hospital with a gradually increasing headache and disturbance of consciousness. Neuroimaging showed hydrocephalus and multiple tumor lesions, including in the brainstem and cerebellum, with uniform gadolinium enhancement on T1-weighted magnetic resonance imaging, as well as spinal cord seeding. Cerebrospinal fluid (CSF) analysis showed a slightly elevated cell count (6/μL; normal, <5/μL) and highly elevated protein (153 mg/dL). In addition, atypical cells were cytologically identified in the CSF. No other laboratory findings were abnormal. Emergency ventricular drainage was performed to control cerebral pressure, followed by a biopsy to confirm the diagnosis. Histological examination revealed a fascicular arrangement of oval cells with eosinophilic cytoplasm and tumor cells with pleomorphic nuclei and prominent nucleoli. Immunohistochemical studies showed negative results for glial fibrillary acidic protein and positive results for desmin and myogenin. In addition, molecular analysis revealed that this tumor had the H3F3A p.Lys28Met mutation and no paired box (PAX)3-forkhead box O1 (FOXO1) or PAX7-FOXO1 fusion genes. ARMS was, therefore, diagnosed. Chemotherapy and radiotherapy were subsequently initiated, but tumor growth could not be controlled, and the patient died 6 months after surgery.

Conclusion:
This report describes an extremely rare case of ARMS arising exclusively within the CNS.
RMC: healthy rumen and productive longevity.
Authors: Латышева О. 
Published: June 2024

Использование кормовой добавки РМЦ позволяет увеличить надои, улучшить воспроизводительную способность коров и продлить их продуктивное долголетие.
Use of the RMC feed additive allows milk yield increase, improvement of cow reproductive ability, and extension of their productive longevity.
ẢNH HƯỞNG CỦA PROTEIN LvCTL3 TÁI TỔ HỢP LÊN CHỈ TIÊU MIỄN DỊCH, TĂNG TRƯỞNG VÀ KHẢ NĂNG KHÁNG BỆNH AHPND TRÊN TÔM THẺ CHÂN TRẮNG (Litopenaeus vannamei) DO Vibrio parahaemolyticus
Authors: Phương Trần Vinh , Linh Nguyễn Quang , Thảo Trần Thị Bách , Anh Nguyễn Đức Quỳnh , Phước Nguyễn Ngọc 
Published: June 2024

Tôm thẻ chân trắng có khối lượng 0,55 ± 0,1 g/con được cho ăn với khẩu phần cơ bản có hoặc không bổ sung protein LvCTL3 tái tổ hợp với các nồng độ lần lượt 100; 200 và 500 µg/mL tương ứng với hàm lượng 2; 4 và 10 mg/kg thức ăn. Sau 30 ngày thí nghiệm tôm được thu thập để xác định các chỉ tiêu tăng trưởng, tỷ lệ sống và máu tôm được lấy để phân tích các chỉ tiêu miễn dịch. Sau đó, tôm được thí nghiệm cảm nhiễm với vi khuẩn V. parahaemolyticus (nồng độ 1 105 CFU/mL). Kết quả các chỉ tiêu tăng trưởng, hệ số chuyển đổi thức ăn và các chỉ tiêu miễn dịch: tổng số tế bào máu, hoạt tính các enzyme: phenoloxidase, Superoxide dismutase (SOD), lysozyme và hoạt động thực bào của máu tôm ở các nghiệm thức thí nghiệm ăn thức ăn có bổ sung protein LvCTL3 tái tổ hợp cao hơn đáng kể so với đối chứng (p < 0,05). Trong đó, tôm được cho ăn chế độ ăn có bổ sung 4 hoặc 10 mg/kg thức ăn có tổng số tế bào máu và SOD được ghi nhận cao hơn so với các nghiệm thức còn lại. Sau 15 ngày cảm nhiễm, tỷ lệ chết tích lũy của tôm ở các nghiệm thức từ 20,0­–36,67%, là thấp hơn đáng kể so với đối chứng (63,66%). ­