bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Novel N‐, S‐Substituted‐polyhalo‐1,3‐butadienes and Crystal Structure of Dibutadienyl Homopiperazine.
Authors: Deniz Nahide Gulsah , Ibis Cemil 
Published: November 2013

AbstractThe title compounds are synthesized by reactions of polyhalo‐2‐nitrobutadienes (I) and (XIII) with different amino‐ and thiol‐nucleophiles.
ChemInform Abstract: NHC‐Catalyzed Annulation of Enals to 2,4‐Dien‐1‐ones: Efficient Diastereoselective Synthesis of 1,3‐Diaryl‐4‐styrenyl Cyclopentenes.
Authors: Sinu C. R. , Padmaja D. V. M. , Jini P. , Lakshmi K. C. Seetha , Nair V. 
Published: November 2013

AbstractA simple NHC‐catalyst promotes the reaction of enals with dienones to give unexpected cyclopentene derivatives (III).
ChemInform Abstract: Rh(I)‐Catalyzed Carbon—Carbon Double‐Bond Formation by Coupling of (Quinolin‐8‐yl)methanone with Arylaldehyde Tosylhydrazone.
Authors: Zhang Yexia , Wang Jingjing , Wang Jianhui 
Published: November 2013

AbstractUnder optimized conditions, the title process affords the corresponding arylvinylated products directly.
ChemInform Abstract: Continuous Flow, Highly Enantioselective Michael Additions Catalyzed by a PS‐Supported Squaramide.
Authors: Kasaplar Pinar , Rodriguez‐Escrich Carles , Paricas Miquel A. 
Published: November 2013

AbstractThe asymmetric addition of naphthoquinone (I) with nitroalkenes is efficiently catalyzed by a polymer‐supported squaramide.
ChemInform Abstract: An Aerobic and Very Fast Pd/C‐Catalyzed Ligand‐Free and Aqueous Suzuki Reaction under Mild Conditions.
Authors: Liu Chun , Rao Xiaofeng , Zhang Yixia , Li Xinmin , Qiu Jieshan , Jin Zilin 
Published: November 2013

AbstractA very simple, green, efficient, and mild protocol for the title reaction is presented with short reaction times.
ChemInform Abstract: Dirhodium Caprolactamate Catalyzed Alkoxyalkylation of Terminal Alkynes.
Authors: Tusun Xiarepati , Lu Chong‐Dao 
Published: November 2013

AbstractDirhodium caprolactamate as catalyst for the tBuOOH promoted reaction of terminal alkynes with cyclic and non‐cyclic alkyl ethers is described to give E/Z mixtures of allyl ethers.
ChemInform Abstract: Domino Elimination/Nucleophilic Addition in the Synthesis of Chiral Pyrrolidines.
Authors: Flores MariFe , Garcia‐Garcia Pilar , Garrido Narciso M. , Marcos Isidro S. , Sanz‐Gonzalez Francisca , Diez David 
Published: November 2013

AbstractPolyhydroxylated pyrrolidines are synthesized in a one‐pot procedure by addition of an organometallic reagent to isoxazolidines obtained by 1,3‐dipolar cycloaddition between nitrones and vinylsulfones.
ChemInform Abstract: Synthesis of Sulfonated Oxindoles by Potassium Iodide Catalyzed Arylsulfonylation of Activated Alkenes with Sulfonylhydrazides in Water.
Authors: Li Xiaoqing , Xu Xiangsheng , Hu Peizhu , Xiao Xuqiong , Zhou Can 
Published: November 2013

AbstractThe reaction works well with differently substituted indoles but only methyl‐ and benzyl protected substrates can be employed.
ChemInform Abstract: Selenium‐Promoted Intramolecular Oxidative Amidation of 2‐(Arylamino)‐acetophenones for the Synthesis of N‐Arylisatins.
Authors: Liu Yong , Chen Hui , Hu Xiong , Zhou Wang , Deng Guo‐Jun 
Published: November 2013

AbstractAn efficient alternative for the synthesis of the title compounds is presented.
ChemInform Abstract: Synthesis of 6H‐Isoindolo[2,1‐α]indol‐6‐ones Through Wittig Reaction and Tandem Reductive Cyclization—Lactamization.
Authors: Kadam Hari K. , Tilve Santosh G. 
Published: November 2013

AbstractA convenient, efficient, and scalable two‐step method for the synthesis of structurally related isoindoloindolones is developed.
ChemInform Abstract: Efficient Consecutive Four‐Component Synthesis of 5‐Acylpyrid‐2‐ones Initiated by Copper‐Free Alkynylation.
Authors: Nordmann Jan , Breuer Natascha , Mueller Thomas J. J. 
Published: November 2013

AbstractThe title one‐pot reaction proceeds under mild reaction conditions and tolerates a broad scope of substrates.
ChemInform Abstract: An Efficient and Convenient Synthesis of Heterocycle‐Fused Indazoles via the N—N Bond Forming Reaction of Nitroarenes Induced by Low‐Valent Titanium Reagent.
Authors: Lin Wei , Hu Ming‐Hua , Feng Xian , Cao Cheng‐Pao , Huang Zhi‐Bin , Shi Da‐Qing 
Published: November 2013

AbstractReductive cyclization of nitroaryl substrates using a low valent titanium reagent allows the synthesis of the title compounds (II) and (IV).
ChemInform Abstract: Studies on the Chemical Reactivity of 1H‐Benzimidazol‐2‐ylacetonitrile Towards Some 3‐Substituted Chromones: Synthesis of Some Novel Pyrido[1,2‐a]benzimidazoles.
Authors: Ibrahim Magdy A. 
Published: November 2013

AbstractCondensation reactions of substrate (II) with various chromones provides pyridobenzimidazole and chromenopyridine derivatives.
ChemInform Abstract: Synthesis of Novel Pyrazoles Incorporating a Phenothiazine Moiety: Unambiguous Structural Characterization of the Regioselectivity in the 1,3‐Dipolar Cycloaddition Reaction Using 2D HMBC NMR Spectroscopy.
Authors: Mekky Ahmed E. M. , Saleh Tamer S. , Al‐Bogami Abdullah S. 
Published: November 2013

AbstractThe microwave assisted 1,3‐dipolar cycloaddition between compounds (I) or (V) with enaminone (II) provides non‐isolable dihydropyrazole intermediates which undergo elimination of dimethylamine to produce pyrazole derivatives (III) and (VI) with high regioselectivity.
ChemInform Abstract: Methyl Trifluoropyruvate N‐(Pyrimidin‐2‐yl)imines in Cyclocondensation Reactions with 1,3‐Binucleophilic Reagents.
Authors: Sokolov V. B. , Aksinenko A. Yu. , Epishina T. A. , Goreva T. V. 
Published: November 2013

AbstractThe functionalization of pharmaceutically significant 2‐aminopyrimidines with trifluoromethyl‐containing five‐membered heterocycles by cyclocondensation reactions of N‐(pyrimidin‐2‐yl)imines (I) with 1,3‐N,N‐ and 1,3‐C,N‐binucleophiles is described.
ChemInform Abstract: S—Co(II) Cascade Catalysis: Cyclocondensation of Aromatic Nitriles with Alkamine.
Authors: Ge Haixia , Liu Ping , Li Xiangnan , Sun Wei , Li Jianli , Yang Bingqin , Shi Zhen 
Published: November 2013

AbstractA catalytic combination of sulfur and Co(II) nitrate allows the direct cyclocondensation of aliphatic aminoalcohols with aromatic nitriles to give oxazines and oxazolines in good yields.
ChemInform Abstract: Expeditive Access to 2‐Substituted 4H‐Pyrido[1,3]oxazin‐4‐ones via an Intramolecular O‐Arylation.
Authors: Slowinski Franck , Ayad Omar Ben , Ziyaret Ozge , Botuha Candice , Le Falher Leatitia , Aouane Kamel , Thorimbert Serge 
Published: November 2013

AbstractA two‐step sequence allows the synthesis of novel pyridooxazinones via aroylation of amides and subsequent intramolecular O‐arylation of the resulting imide sodium salts.
ChemInform Abstract: Studies on Chalcogen‐Containing Heterocycles. Part 38. Regio‐ and Stereoselective Tandem Addition—Iodocyclization of 2‐Ethynylphenyl Isothiocyanates with N‐ and O‐Nucleophiles Affording 4‐(Iodoalkylidene)benzo[d][1,3]thiazines.
Authors: Sashida Haruki , Kaname Mamoru , Minoura Mao 
Published: November 2013

AbstractThe title reaction of substrates (I) with amines provides the E‐isomers (III) and (V) as sole products whereas substrate (VI) gives the Z‐isomers (VII) and (IX) under the same conditions.
ChemInform Abstract: A Highly Chemoselective and Practical Alkynylation of Thiols.
Authors: Frei Reto , Waser Jerome 
Published: November 2013

AbstractA thiol‐alkynylation procedure applies a hypervalent iodine alkyne agent and can be applied to a wide range of aromatic, aliphatic, heteroaromatic thiols as well as to cysteines and peptides.
ChemInform Abstract: Thaixylomolins A—C: Limonoids Featuring Two New Motifs from the Thai Xylocarpus moluccensis.
Authors: Li Jun , Li Min‐Yi , Bruhn Torsten , Katele Felix Zongwe , Xiao Qiang , Pedpradab Patchara , Wu Jun , Bringmann Gerhard 
Published: November 2013

AbstractThaixylomolins A (I), B (IIa), and C (IIb) are isolated and their absolute configurations determined.
ChemInform Abstract: Enantioselective Synthesis of H‐Phosphinic Acids Bearing Natural Amino Acid Residues.
Authors: Yao Qiuli , Yuan Chengye 
Published: November 2013

AbstractThe asymmetric synthesis of phosphorus analogues of α‐amino acids on the basis of the enantioselective addition of phosphinates to N‐tert‐butanesulfinyl imines is presented.
ChemInform Abstract: Lyngbouilloside and Related Macrolides from Marine Cyanobacteria
Authors: El Marrouni Abdelatif , Kolleth Amandine , Lebeuf Raphael , Gebauer Julian , Prevost Sebastien , Heras Montserrat , Arseniyadis Stellios , Cossy Janine 
Published: November 2013

AbstractReview: strategies to synthesize these natural products; 72 refs.
Epigenetic silencing of CHD5, a novel tumor‐suppressor gene, occurs in early colorectal cancer stages
Authors: Fatemi Mehrnaz , Paul Thomas A. , Brodeur Garrett M. , Shokrani Babak , Brim Hassan , Ashktorab Hassan 
Published: November 2013

BACKGROUNDChromodomain helicase DNA binding protein 5 (CHD5) is a family member of chromatin remodeling factors. The epigenetic silencing mechanisms of CHD5 in colorectal cancer have not been well studied.METHODSHere we analyzed CHD5 methylation and mRNA expression in vitro and in clinical samples from African American patients. DNA and RNA were isolated from formalin fixed paraffin embedded (FFPE) colon tissues. DNA was tested for methylation using methylation‐specific polymerase chain reation (PCR) and bisulfite sequencing. RNA was used for mRNA quantification using qRT‐PCR. The RKO cell line was treated with 5‐Aza‐dC and SAHA. RKO cells were also stably transfected with a CHD5‐expressing vector. The transcriptional activity was studied in the 1 kb upstream region of the CHD5 promoter using the dual reporter assay. We performed cell proliferation, migration, and invasion assays using the RKO cell line.RESULTSIn most adenoma samples, CHD5 expression was not detected in contrast to normal tissues. In RKO cells, CHD5 silencing was associated with DNA methylation and repressive histone modifications. CHD5 expression was restored after treatment with 5‐Aza‐dC and SAHA. CHD5 reactivation reduced cell proliferation, migration, and invasion. The reporter assay indicated that the main regulatory region of the CHD5 promoter is encompassed in the −489 to −823 region with important transcriptional regulatory sites (TCF/LEF, SP1, and AP‐2).CONCLUSIONSThe CHD5 gene is repressed in all types of adenomas, either epigenetically or by chromosomal deletion. CHD5 activity is regulated by DNA methylation and repressive histone modifications. CHD5 likely acts as a tumor‐suppressor gene in early colorectal carcinogenesis. Cancer 2014;120:172–180. © 2013 American Cancer Society.
A stable approach for coupling multidimensional cardiovascular and pulmonary networks based on a novel pressure‐flow rate or pressure‐only Neumann boundary condition formulation
Authors: Ismail M. , Gravemeier V. , Comerford A. , Wall W.A. 
Published: November 2013

SUMMARYIn many biomedical flow problems, reversed flows along with standard treatment of Neumann boundary conditions can cause instabilities. We have developed a method that resolves these instabilities in a consistent way while maintaining correct pressure and flow rate values. We also are able to remove the necessary prescription of both pressure and velocities/flow rates to problems where only pressure is known. In addition, the method is extended to coupled 3D/reduced‐D fluid and fluid‐structure interaction models. Numerical examples mainly focus on using Neumann boundary condition in cardiovascular and pulmonary systems, particularly, coupled with 3D‐1D and 3D‐0D models. Inflow pressure, traction, and impedance boundary conditions are first tested on idealized tubes for various Womersley numbers. Both pressure and flow rate are shown to match the analytical solutions for these examples. Our method is then tested on a coupled 1D‐3D‐1D artery example, demonstrating the power and simplicity of extending this method toward fluid‐structure interaction. Finally, the proposed method is investigated for a coupled 3D‐0D patient‐specific full lung model during spontaneous breathing. All coupled 3D/reduced‐D results show a perfect matching of pressure and flow rate between 3D and corresponding reduced‐D boundaries. The methods are straight‐forward to implement in contrast to using Lagrange multipliers as previously proposed in other studies. Copyright © 2013 John Wiley & Sons, Ltd.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of vilanterol, a novel inhaled long‐acting β‐agonist, in children aged 5–11 years with persistent asthma: A randomized trial
Authors: Oliver Amanda , VanBuren Sandi , Allen Ann , Hamilton Melanie , Tombs Lee , Kempsford Rodger , Qaqundah Paul 
Published: November 2013

AbstractThis multi‐center, randomized, double‐blind, placebo‐controlled, two‐way crossover study was designed to characterize the safety, tolerability, pharmacokinetic, and pharmacodynamic profile of single and once‐daily repeat doses of vilanterol 25 µg in children aged 5–11 years. Twenty‐eight children with persistent asthma received a single inhaled dose of vilanterol 25 µg or placebo via the ELLIPTA™ dry powder inhaler (DPI) on Day 1, followed 7 days later by once‐daily treatment for 7 days. Nine (33%) subjects reported adverse events (AEs) with vilanterol 25 µg and 6 (23%) with placebo. No serious or drug‐related AEs were reported; 3 subjects experienced upper respiratory tract infection (URTI) with vilanterol 25 µg versus none with placebo. Similar pharmacokinetic profiles of vilanterol 25 µg were observed irrespective of age or gender. No clinically relevant changes in heart rate, Fridericia's correction (QTcF), maximum glucose or minimum potassium parameters were observed during treatment with vilanterol 25 µg compared with placebo treatment. Vilanterol was well‐tolerated and no long‐acting ß2‐agonist (LABA)‐mediated AEs were observed. The pharmacokinetic profile of vilanterol 25 µg suggests exposure is similar regardless of age or gender in a pediatric population aged 5–11 years.
An Open Trial of ‘Grief‐Help’: A Cognitive–Behavioural Treatment for Prolonged Grief in Children and Adolescents
Authors: Spuij Mariken , Dekovic Maja , Boelen Paul A. 
Published: November 2013

In the past years, there is growing recognition of a syndrome of disturbed grief referred to as prolonged grief disorder (PGD). Although mostly studied in adults, clinically significant PGD symptoms have also been observed in children and adolescents. To date, no effective treatment for childhood PGD yet exists. We recently developed a nine‐session cognitive–behavioural treatment for childhood PGD combined with five sessions of parental counselling. In the current article, we present outcomes of treatment of 10 consecutive children and adolescents turning to our university clinic with elevated PGD symptoms as their primary problem and main reason to seek therapy. Patients were significantly improved at post‐treatment, with large improvements in self‐rated PGD and post‐traumatic stress (effect sizes > 0.8) and small to moderate improvement in depression and parent‐rated internalizing and externalizing problems (0.2 < effect sizes < 0.8). Additional predictor analysis of outcomes suggested that, among other things, this treatment approach is less efficacious for children and adolescents further removed from loss and those confronted with suicidal loss. That said, the treatment appears promising, and controlled evaluation is clearly indicated. Copyright © 2013 John Wiley & Sons, Ltd.Key Practitioner Message

We developed ‘Grief‐Help’, a nine‐session cognitive–behavioural treatment for childhood prolonged grief combined with five sessions of parental counselling.
Results of the treatment of 10 consecutive children and adolescents are reported in this article.
Patients were significantly improved at post‐treatment, with large improvements in prolonged grief and post‐traumatic stress (effect sizes > 0.8) and small to moderate improvement in depression and internalizing and externalizing problems (0.2 < effect sizes < 0.8).
Predictor analysis, using data from 16 patients, suggested that this treatment is less efficacious for children and adolescents further removed from loss and those confronted with suicidal loss.
This study provides further evidence that ‘Grief‐Help’ is a promising approach to the treatment of childhood prolonged grief.
Preparation and upconversion luminescence characterization of 12CaO·7Al2O3:Ho3+/Yb3+ polycrystals
Authors: Qu Yunfei , Wang Rui , Liu Liang , Sun Jinchao , Xing Lili , Tao Ye , Wu Xiaohong 
Published: November 2013

The effect of Yb3+ concentration on the fluorescence of 12CaO·7 Al2O3:Ho3+/Yb3+ polycrystals is investigated. The Raman spectra of pure C12A7 under 633‐nm excitation show that the highest photon energy is 787.267 cm−1, which is not much bigger than general fluorides, so it can realize high efficiency upconversion. The upconversion emission spectra suggest that the green upconversion emission centered at 548 nm and the red upconversion emission at 662 nm correspond to the 5F4/5S2→5I8 and 5F5→5I8 transition of Ho3+ ions, respectively. The intensity of the upconversion luminescence and the ratio of red to green are changed with Yb3+ ion concentration. The pump dependence and luminescence decay dynamics spectra show the green and red upconversion emissions are populated by a two‐photon process, and the upconversion mechanisms are analyzed. The relative luminous efficiencies of green and red emissions are 2.035% and 0.7%, respectively. The normalized efficiency obtained for green emission of Ho3+ at RT when the sample is excited by 980‐nm light with an absorbed intensity of 7.5 W/cm2 is 0.27 cm2/W. This result is comparable to the values obtained in YF3 for the Yb3+, Er3+ green emission. The C12A7 with upconversion red and green light will be a promising luminous material.
Changes in the temperature sensitivity of SOM decomposition with grassland succession: implications for soil C sequestration
Authors: Nianpeng He , Ruomeng Wang , Yang Gao , Jingzhong Dai , Xuefa Wen , Guirui Yu 
Published: November 2013

AbstractUnderstanding the temperature sensitivity (Q10) of soil organic matter (SOM) decomposition is important for predicting soil carbon (C) sequestration in terrestrial ecosystems under warming scenarios. Whether Q10 varies predictably with ecosystem succession and the ways in which the stoichiometry of input SOM influences Q10 remain largely unknown. We investigate these issues using a grassland succession series from free‐grazing to 31‐year grazing‐exclusion grasslands in Inner Mongolia, and an incubation experiment performed at six temperatures (0, 5, 10, 15, 20, and 25°C) and with four substrates: control (CK), glucose (GLU), mixed grass leaf (GRA), and Medicago falcata leaf (MED). The results showed that basal soil respiration (20°C) and microbial biomass C (MBC) logarithmically decreased with grassland succession. Q10 decreased logarithmically from 1.43 in free‐grazing grasslands to 1.22 in 31‐year grazing‐exclusion grasslands. Q10 increased significantly with the addition of substrates, and the Q10 levels increased with increase in N:C ratios of substrate. Moreover, accumulated C mineralization was controlled by the N:C ratio of newly input SOM and by incubation temperature. Changes in Q10 with grassland ecosystem succession are controlled by the stoichiometry of newly input SOM, MBC, and SOM quality, and the combined effects of which could partially explain the mechanisms underlying soil C sequestration in the long‐term grazing‐exclusion grasslands in Inner Mongolia, China. The findings highlight the effect of substrate stoichiometry on Q10 which requires further study.
Highly Enantioselective Alkylation of Allyl Acetates Using Tartrate‐Derived Bioxazoline Ligands
Authors: Jayakumar Samydurai , Prakash Muthuraj , Balaraman Kaluvu , Kesavan Venkitasamy 
Published: November 2013

AbstractTartrate‐derived bioxazoline ligands, which form a five‐membered chelate ring with metals, were evaluated for use in the asymmetric allylic alkylation (AAA) reactions of various symmetrical and unsymmetrical allyl acetates. Excellent enantioselectivities were achieved by using both symmetrical and unsymmetrical allyl acetates.
Trends in Anorexia Nervosa Research: An Analysis of the Top 100 Most Cited Works
Authors: Lipsman Nir , Woodside D. Blake , Lozano Andres M. 
Published: November 2013

AbstractAnalysis of highly cited papers provides unique insights into the status of research in a given field. We sought to identify the top 100 most highly cited papers in the field of anorexia nervosa (AN). A free, publically accessible software was used to conduct an online search of publications with accompanying citation data. Search terms were selected to focus on papers dealing predominantly with AN, and the results manually screened to exclude out‐of‐scope publications. Papers in bulimia nervosa, eating disorder not otherwise specified and binge‐eating disorder, were not included. The top 100 most highly cited papers in the AN field were identified. Of these, 34 garnered greater than 400 citations, classifying them as ‘citation classics’. These works were divided into five categories, those dealing with epidemiological trends, medical/psychiatric comorbidities, treatment, mechanisms of disease and measurement/classification. Publications examining the epidemiology and underlying mechanisms of AN account for the majority of the top 100 papers. Scales and measurement tools have had the greatest impact, garnering the greatest number of average citations per paper. Although reasonably diverse, the top 100 papers highlight areas still lagging behind, including the neuroscience of AN as well as research into novel treatment strategies. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
Evaluation of the UTRAN (HSPA) performance in different configurations in the presence of M2M and online gaming traffic
Authors: Popović Milica , Drajić Dejan , Krčo Srdjan 
Published: November 2013

AbstractIn this paper, performance analysis of a High Speed Packet Access network in the presence of machine‐to‐machine (M2M) and online gaming traffic is described. The evaluation was performed in a live network, using a number of mobile phones to generate additional traffic load. One Node B, with different configurations, was used throughout the experiments. The main areas of impact are identified, and similar underlying mechanisms are later recognised through deployment of a commercial large‐scale M2M application. The paper describes the key findings of the analysis of five test cases from the network performance aspect. It further associates perceived network behaviour with the end‐user experience in terms of the average delays. At the end, a comparison with the observed impacts of a live M2M application is given, and the main issues highlighted, together with a discussion on possible solutions. Copyright © 2013 John Wiley & Sons, Ltd.