bluuebunny/crossref_metadata_2025_split huggingface dataset:
History, pelvic examination findings and mobility of ovaries as a sonographic marker to detect pelvic adhesions with fixed ovaries
Authors: Marasinghe Jeevan Prasanga , Senanayake Hemantha , Saravanabhava Namasivayam , Arambepola Carukshi , Condous George , Greenwood Peter 
Published: November 2013

AbstractAimTo compare the performance of history and examination findings combined with transvaginal ultrasound (TVS) ‘soft marker’ evaluation of ovarian mobility for the prediction of fixed ovaries secondary to endometriosis at laparoscopy.MethodsThis was a prospective observational study performed at the University Gynecology unit, National Hospital of Colombo Sri Lanka. Women who were scheduled for laparoscopic assessment of their pelvis to investigate subfertility or chronic pelvic pain were enrolled. All women underwent history evaluation for dysmenorrhea and dyspareunia, vaginal examination and detailed presurgical TVS. TVS was used to assess ‘soft marker’ of ovarian mobility. ‘Fixed’ ovaries on ultrasound were defined as one or other of the ovaries being fixed or adherent to the internal iliac artery or pelvic sidewall laterally or to the uterus medially. These findings were compared with ‘fixed’ ovaries confirmed at laparoscopy.ResultsA total of 106 patients were analyzed. Mean age was 33.3 years (standard deviation, 5.1). Sensitivity, specificity, positive and negative predictive values of each of the screening methods against laparoscopy in detecting endometriosis were as follows: dyspareunia, 45.9%, 76.8%, 51.5% and 72.6%; dysmenorrhea, 75.7%, 69.6%, 57.1% and 84.2%; positive vaginal examination, 73%, 88.4%, 77.1% and 85.9%; fixed ovaries with TVS, 78.4%, 94.2%, 87.9% and 89%; and a combination of history, examination findings and detection of fixed ovaries in TVS, 91.9%, 60.9%, 55.7% and 93.3%, respectively.ConclusionA combination of clinical and TVS‐based ‘soft marker’ of ovarian mobility provides a valid method for identifying fixed ovaries secondary to endometriosis.
Effects of body mass index and body fat percentage on gestational complications and outcomes
Authors: Zhao Ya‐Ning , Li Qin , Li Yan‐Chuan 
Published: November 2013

AbstractAimThe aim of this study was to investigate the correlation between body mass index (BMI), body fat percentage (BFP) and gestational outcomes.Material and MethodsMaternal‐ and infant‐related data of gestation and gestational outcomes of 411 pregnant women were retrospectively analyzed. BMI was used to classify the women as obese, overweight, or normal. BFP was measured by the segmental multi‐frequency bioelectrical impedance method. The mothers' blood lipid profiles were assessed by automated chemical analysis. Logistic regression analysis was performed to determine the correlation of BMI and BFP with gestational complications.ResultsThe rates of gestational diabetes and hypertension were significantly different between mothers who were obese (33.3%, 52.6%), overweight (10.3%, 32.2%) and normal (8.7%, 14.9%) (P < 0.001). The Apgar score at 1 min and intensive care unit admissions rate at birth were significantly different between infants born to obese (6.14 ± 0.80, 14.0%), overweight (6.64 ± 1.10, 8.9%) and normal (7.20 ± 0.78, 1.9%) mothers (P < 0.01). The Apgar score at 5 min and the birthweights were not significantly different between these three groups (P > 0.05). Additionally, the levels of serum total cholesterol (mmol/L), total triglycerides (mmol/L), and leptin (ng/mL) were significantly higher in obese (5.87 ± 2.26, 2.04 ± 1.65, 24.79 ± 18.38) and overweight (5.29 ± 1.85, 1.74 ± 1.05, 20.79 ± 15.19) women, compared to normal women (4.89 ± 1.05, 1.45 ± 0.77, 13.35 ± 6.51) (P < 0.05). Furthermore, BFP was more strongly correlated to gestational diabetes (rs = 0.57 vs 0.68) and hypertension (rs = 0.31 vs 0.43) than BMI.ConclusionsObesity and overweight are associated with increased adverse maternal and neonatal complications. BFP is a more accurate predictor of gestational outcomes than BMI.
The impact of CO2 emission scenarios and nutrient enrichment on a common coral reef macroalga is modified by temporal effects
Authors: Bender Dorothea , Diaz‐Pulido Guillermo , Dove Sophie 
Published: November 2013

Future coral reefs are expected to be subject to higher pCO2 and temperature due to anthropogenic greenhouse gas emissions. Such global stressors are often paired with local stressors thereby potentially modifying the response of organisms. Benthic macroalgae are strong competitors to corals and are assumed to do well under future conditions. The present study aimed to assess the impact of past and future CO2 emission scenarios as well as nutrient enrichment on the growth, productivity, pigment, and tissue nutrient content of the common tropical brown alga Chnoospora implexa. Two experiments were conducted to assess the differential impacts of the manipulated conditions in winter and spring. Chnoospora implexa's growth rate averaged over winter and spring declined with increasing pCO2 and temperature. Furthermore, nutrient enrichment did not affect growth. Highest growth was observed under spring pre‐industrial (PI) conditions, while slightly reduced growth was observed under winter A1FI (“business‐as‐usual”) scenarios. Productivity was not a good proxy for growth, as net O2 flux increased under A1FI conditions. Nutrient enrichment, whilst not affecting growth, led to luxury nutrient uptake that was greater in winter than in spring. The findings suggest that in contrast with previous work, C. implexa is not likely to show enhanced growth under future conditions in isolation or in conjunction with nutrient enrichment. Instead, the results suggest that greatest growth rates for this species appear to be a feature of the PI past, with A1FI winter conditions leading to potential decreases in the abundance of this species from present day levels.
Prevalence of Symptoms and Associated Comorbidities of Testosterone Deficiency Syndrome in the Korean General Population
Authors: Moon Du Geon , Kim Jin Wook , Kim Je Jong , Park Kwang Sung , Park Jong Kwan , Park Nam Cheol , Kim Sae Woong , Lee Sung Won 
Published: November 2013

Abstract

Introduction
Testosterone deficiency syndrome (TDS) is a prevalent disease of the aging male with much confusion to its associated presentation, diagnosis, and comorbidities.

Aim
We investigated the overall prevalence of TDS and its putative symptoms and associated diseases in a nationwide study on participants recruited from routine checkup.

Methods
One thousand eight hundred seventy-five participants seeking biennial health checkup were enrolled from a nationwide distribution of randomly selected registry of primary clinics. Putative symptoms and comorbidities were assessed for serum testosterone-dependent prevalence change, independent of age. The identified symptoms were then assessed by multivariate backward stepwise binominal regression to determine the optimal reference level of testosterone and the strength of the associated comorbidities.

Main Outcome Measures
TDS was assessed by serum testosterone, the Aging Males' Symptom scale, and the Androgen Deficiency in Aging Male questionnaire. Patient body habitus measurements and history of associated comorbidities were also described. The dependent variables included the age-specific prevalence of decreased testosterone and the probability of TDS-specific symptoms.

Results
Grossly 10.2% of the participants fell into the criteria for TDS. Testosterone was highly age dependent, and most putative symptoms of TDS showed significant age dependence but was not affected by serum testosterone levels. However, the symptoms of decreased libido and erectile dysfunction, and comorbidities such as hypertension, type 2 diabetes, and obesity showed relevant dependence on serum testosterone levels as well as age above 50 years of age. Furthermore, these symptoms were also affected at different serum testosterone thresholds. Decreased libido increased significantly at serum testosterone levels of 550 ng/dL (odds ratio [OR] = 1.295, 95% confidence interval [CI] = 1.047–1.601), and erectile dysfunction was affected by serum testosterone levels at 250 ng/dL (OR = 1.369, 95% CI = 1.005–1.866).

Conclusions
Most symptoms and diseases thought to be associated with TDS are primarily age dependent. Few sexual symptoms and diseases such as hypertension, diabetes, and obesity show testosterone dependence only at older ages.
A critical role of hypocretin deficiency in pregnancy
Authors: Bastianini Stefano , Berteotti Chiara , Lo Martire Viviana , Silvani Alessandro , Zoccoli Giovanna 
Published: November 2013

SummaryHypocretin/orexin peptides are known for their role in the control of the wake–sleep cycle and narcolepsy–cataplexy pathophysiology. Recent studies suggested that hypocretin peptides also have a role in pregnancy. We tested this hypothesis by conducting a retrospective analysis on pregnancy complications in two different mouse models of hypocretin deficiency. We recorded 85 pregnancies of mice lacking either hypocretin peptides (knockout) or hypocretin‐releasing neurons (transgenic) and their wild‐type controls. Pregnancy was associated with unexplained dam death before delivery in 3/15 pregnancies in knockout mice, and in 3/23 pregnancies in transgenic mice. No casualties occurred in wild‐type pregnant dams (P < 0.007 versus hypocretin‐deficient mice as a whole). Hypocretin deficiency did not impact either on litter size or the number of weaned pups per litter. These data provide preliminary evidence of a critical role of hypocretin deficiency in pregnancy.
Consensus Recommendations for the Diagnostic Investigation of Dogs with Suspected Glomerular Disease
Authors:   IRIS Canine GN Study Group Diagnosis Subgroup, Littman M.P. , Daminet S. , Grauer G.F. , Lees G.E. , van Dongen A.M. 
Published: November 2013

BackgroundThe International Renal Interest Society (IRIS) offers guidelines for chronic kidney disease and acute kidney injury. As dogs with glomerular disease may present differently and require different treatment than those with whole nephron or tubular disease, the IRIS Canine Glomerulonephritis (GN) Study Group was convened to formulate guidelines for these cases. The Diagnosis Subgroup was asked to make recommendations for diagnostic evaluation of such cases.ObjectiveTo seek consensus among renal specialists for the evaluation of dogs with proteinuria because of suspected glomerular disease.MethodsAfter reviewing the literature, subgroup members discussed and wrote the draft paper and recommendations, which members of the IRIS Canine GN Study Group voted upon by electronic secret ballot, with comments noted. Consensus was declared if votes showed strong or general agreement from 85% of the respondents.ResultsDiagnostic tests were categorized as essential, recommended, or potentially helpful, with prioritization dependent on case characteristics, eg, for cases with uncomplicated proteinuria versus complicated with hypoalbuminemia, azotemia, or both. Consensus was reached with 86–100% agreement on all questions posed. All cases should have basic examinations including blood pressure measurement, blood, and urine testing, and a search for infectious diseases relevant to their environs. The majority ranked imaging (chest radiographs, abdominal ultrasonogram) and renal biopsy procured and interpreted by experienced personnel as essential evaluations in complicated cases, but a few respondents deemed these to be essential in uncomplicated cases as well.Conclusions and Clinical ImportanceStrong consensus about recommendations for diagnostic evaluation of dogs with suspected glomerular protein loss was attained. These guidelines help clinicians characterize disease processes for more informed therapeutic decision‐making.
Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long‐lived seabird
Authors: Bauch Christina , Becker Peter H. , Verhulst Simon 
Published: November 2013

AbstractTelomeres, DNA‐protein structures at chromosome ends, shorten with age, and telomere length has been linked to age‐related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysis. This yields a distribution of telomere lengths for each sample, and we investigated how different telomere subpopulations (percentiles) varied in their relation to age and fitness proxies. Longer telomeres within a genome lost more base pairs with age and were better predictors of survival than shorter telomeres. Likewise, fitness proxies such as arrival date at the breeding grounds and reproductive success were best predicted by telomere length at the higher percentiles. Our finding that longer telomeres within a genome predict fitness components better than the shorter telomeres indicates that they are a more informative ageing biomarker. This finding contrasts with the fact that cell senescence is triggered by the shortest telomeres. We suggest that this paradox arises, because longer telomeres lose more base pairs per unit time and thus better reflect the various forms of stress that accelerate telomere shortening, and that telomeres primarily function as biomarker because their shortening reflects cumulative effects of various stressors rather than reflecting telomere‐induced cell senescence.
Epilogue: Emergent (re‐)assemblings of biological economies
Authors: Lewis Nick , Rosin Christopher 
Published: November 2013

AbstractThis paper presents an epilogue to the Special Issue. The paper examines the interplay among ontology, epistemology, methodology, politics and geography by elaborating on Esbjörn‐Hargen's framework of the ‘who’, ‘what’ and ‘how’ of knowledge making. It uses this discussion to relate the different papers in the Special Issue, traces the engagement of the authors with concepts of assemblage and considers the further work to which the concept of assemblage might be put by exploring potential new research directions emerging from the Biological Economies research project.
Transvenous Atrial Pacing from the Superior Vena Cava Stump after the Hemi‐Fontan Operation—A New Approach
Authors: ROSENTHAL ERIC , KONTA LAURA 
Published: November 2013

BackgroundThe placement of a standard endocardial pacemaker system is challenging after a superior cavopulmonary connection (hemi‐Fontan operation or Glenn shunt) as the continuity between the superior vena cava (SVC) and right atrium is divided. The standard transvenous approach for endocardial lead placement has therefore in general been avoided, and epicardial leads have been placed.MethodsIn three patients after a hemi‐Fontan procedure, we found viable atrial tissue in the SVC stump of the superior cavopulmonary anastomosis, which was still connected electrically to the right atrium into which active‐fixation leads could be safely implanted.ResultsThere was excellent short‐ and long‐term atrial pacing and sensing characteristics in the SVC stump.ConclusionsWe describe a technique for transvenous pacing in patients after the hemi‐Fontan procedure using the conventional subclavian vein approach and pectoral placement of the generator. For ventricular pacing, it was possible to cross the patch dividing the right atrium from the SVC either using a spontaneous leak or by needle puncture.
Wrinkled Skin and Fat Pads in Patients with ALG8‐CDG: Revisiting Skin Manifestations in Congenital Disorders of Glycosylation
Authors: Kouwenberg Dorus , Gardeitchik Thatjana , Mohamed Miski , Lefeber Dirk J. , Morava Eva 
Published: November 2013

AbstractGlycosylation is the posttranslational coupling of sugar chains to proteins or lipids. Proper glycosylation is essential for normal protein structure, function, and trafficking. Mutations in the glycosylation pathway lead to a phenotypically heterogeneous group of metabolic disorders, the congenital disorders of glycosylation (CDG). Some of these conditions, including PMM2‐CDG, frequently present with recognizable skin abnormalities such as abnormal fat distribution, skin wrinkling, or peau d'orange, whereas others, such as COG7‐CDG and ATP6V0A2‐CDG, have been described in association with cutis laxa: wrinkled, inelastic, and sagging skin. Ichthyosis is also common in several types of CDG. ALG8‐CDG is a severe disorder characterized by dysmorphic features, failure to thrive, protein‐losing enteropathy, neurologic and ophthalmologic problems, and developmental delay. We reviewed the clinical features in all nine previously reported patients diagnosed with ALG8‐CDG with a special focus on their skin signs. Three of the nine patients had abnormal fat distribution and skin wrinkling. As the spectrum of CDG presenting with skin signs expands further, we suggest screening for CDG in all patients presenting with any type of central nervous involvement and wrinkled skin, cutis laxa, severe ichthyosis, or abnormal fat distribution.
Acne Vulgaris in Preadolescent Children: Recommendations for Evaluation
Authors: Bree Alanna F. , Siegfried Elaine C. 
Published: November 2013

AbstractAcne vulgaris in infants and children often triggers extensive laboratory evaluation out of concern about associated endocrinopathy. Clinical parameters to help guide evaluation of these children have not been defined. This was a retrospective chart review of 24 preadolescent patients with acne and a review of related medical literature. Two age‐related subsets were identified: 12 patients who developed acne before the age of 15 months, 75% male, with comedonal and inflammatory lesions; and 12 patients who developed acne between the ages of 2 and 7 years, 75% female, with primarily comedonal lesions. Laboratory evaluation in 13 of the patients was unremarkable. Bone age was advanced in 1 of the 11 children imaged. Premature adrenarche was diagnosed in four patients; all four had additional clinical signs of puberty and growth parameters >90th percentile. None required additional treatment. Our cohort of preadolescent children presenting with acne included an equal number of patients in two distinct subsets: infantile and childhood‐onset acne. Literature review identified a rare third subset presenting with acne, signs of advanced puberty, and associated endocrinopathy. There was no evidence of endocrinopathy in our patients with infantile acne. Two‐thirds of our patients with childhood‐onset acne had no additional clinical signs of puberty and no evidence of endocrinopathy. A focused history and physical examination is sufficient to evaluate the majority of infants and children with acne. Hand X‐ray for bone age is a useful screening test. Further evaluation and endocrinology referral are warranted in preadolescents with acne and advanced bone age or additional clinical evidence of early puberty.
Familial Papular Epidermal Nevus with “Skyline” Basal Cell Layer
Authors: Brena Michela , Besagni Francesca , Boneschi Vinicio , Tadini Gianluca 
Published: November 2013

AbstractPapular epidermal nevus with “skyline” basal cell layer (PENS), a novel keratinocytic nevus, has recently been described as a mosaic condition with varying presentations. We herein describe typical PENS lesions, which usually occur sporadically, affecting two members of the same family. The concept of paradominant inheritance is proposed to explain the paradox of occasional transmission of normally sporadically occurring traits.
Hand Function and Quality of Life in Children with Epidermolysis Bullosa
Authors: Eismann Emily A. , Lucky Anne W. , Cornwall Roger 
Published: November 2013

AbstractPatient‐reported outcomes are becoming increasingly important to clinical care. Epidermolysis bullosa (EB), a rare genetic skin disorder, can result in severe hand impairment, but parent and patient perceptions of hand function have never been assessed. This study aimed to quantify parent‐ and patient‐reported hand function and assess its relationship with quality of life (QOL) in children with EB. This cross‐sectional study included children with EB treated at an interdisciplinary EB center. Hospital records were searched for demographic characteristics and medical history. Eligible families were invited to complete two surveys by mail or telephone. The ABILHAND‐Kids questionnaire assessed manual hand ability for 21 functions. The Quality of Life in Epidermolysis Bullosa questionnaire assessed EB‐related QOL. Hand function and QOL of various subtypes were compared using Mann–Whitney tests. Seventy‐one parents and patients ages 2 to 18 years with EB from 20 states in the United States completed questionnaires. Children with recessive dystrophic EB reported the worst hand function and QOL. Bimanual functions involving finger mobility were the most challenging for all EB subtypes. QOL was highly related to the degree of hand function, being correlated with 20 of the 21 individual hand functions and most associated with the ability to perform unimanual functions. Parent‐ and patient‐reported hand function can be measured in children with EB using the ABILHAND‐Kids questionnaire. Hand impairment is strongly associated with worse QOL, probably due to difficulty performing daily activities. The effect of interventions such as hand surgery could be prospectively evaluated using this questionnaire.
Harlequin Ichthyosis: Neonatal Management and Identification of a New ABCA12 Mutation
Authors: Koochek Arash , Choate Keith A. , Milstone Leonard M. 
Published: November 2013

AbstractA case of harlequin ichthyosis with compound heterozygous mutations in ABCA12 was successfully managed with intensive neonatal care and endotracheal intubation and without oral retinoids. The individual's appearance improved dramatically during hospitalization and at discharge resembled congenital ichthyosiform erythroderma.
Intracranial hemorrhage in infants with cephalohematoma
Authors: Kim Heng Mi , Kwon Soon Hak , Park Sook Hyun , Kim Yong Sun , Oh Ki Won 
Published: November 2013

AbstractBackgroundIntracranial hemorrhage (ICH) is a rare birth injury in term infants. Newborn infants with cephalohematoma (CH) associated with ICH, however, have frequently been found incidentally at Kyungpook National University Hospital; many of them had no neurological symptoms. The aim of this study was to evaluate the clinical manifestations of ICH in newborn infants with CH.MethodsNewborn infants with CH in the neonatal intensive care unit were retrospectively evaluated. During period I (5 years), neuroimaging (brain computed tomography and magnetic resonance imaging) was performed when intracranial abnormalities were suspected. During period II (36 months) neuroimaging was performed when CH > 5 cm in diameter was present.ResultsDuring period I, seven out of 19 infants who underwent neuroimaging had ICH (36.8%) including two epidural hemorrhages (EDH). During period II, 18 out of 27 infants who underwent neuroimaging had ICH (66.7%), including two EDH. There was no significant difference in the clinical manifestations between infants with and without ICH. In 10 cases of CH accompanied with a linear skull fracture, nine had ICH, including all cases of ICH that needed intervention.ConclusionsThe association of ICH appears to be common in newborn infants with CH; particularly in infants with CH accompanied with a skull fracture, the rate of ICH was very high, and all cases of EDH requiring intervention were associated with skull fracture. Therefore, evaluation of accompanying skull fracture should be required in infants with CH, and, in cases of skull fracture, neuroimaging should be considered.