bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mechanisms and environmental adaptations of flagellar loss and biofilm growth of Rhodanobacter under environmental stress
Authors: Chen Mingfei , Trotter Valentine V , Walian Peter J , Chen Yan , Lopez Romario , Lui Lauren M , Nielsen Torben N , Malana Ria Gracielle , Thorgersen Michael P , Hendrickson Andrew J , Carion Héloïse , Deutschbauer Adam M , Petzold Christopher J , Smith Heidi J , Arkin Adam P , Adams Michael W W , Fields Matthew W , Chakraborty Romy 
Published: August 2024

Abstract
Biofilms aid bacterial adhesion to surfaces via direct and indirect mechanisms, and formation of biofilms is considered as an important strategy for adaptation and survival in suboptimal environmental conditions. However, the molecular underpinnings of biofilm formation in subsurface sediment/groundwater ecosystems where microorganisms often experience fluctuations in nutrient input, pH, and nitrate or metal concentrations are underexplored. We examined biofilm formation under different nutrient, pH, metal, and nitrate regimens of 16 Rhodanobacter strains isolated from subsurface groundwater wells spanning diverse levels of pH (3.5 to 5) and nitrates (13.7 to 146 mM). Eight Rhodanobacter strains demonstrated significant biofilm growth under low pH, suggesting adaptations for survival and growth at low pH. Biofilms were intensified under aluminum stress, particularly in strains possessing fewer genetic traits associated with biofilm formation, findings warranting further investigation. Through random barcode transposon-site sequencing (RB-TnSeq), proteomics, use of specific mutants, and transmission electron microscopy analysis, we discovered flagellar loss under aluminum stress, indicating a potential relationship between motility, metal tolerance, and biofilm growth. Comparative genomic analyses revealed the absence of flagella and chemotaxis genes and the presence of a putative type VI secretion system in the highly biofilm-forming strain FW021-MT20. In this study we identified genetic determinants associated with biofilm growth under metal stress in a predominant environmental genus, Rhodanobacter, and identified traits aiding survival and adaptation to contaminated subsurface environments.
Niche separation in bacterial communities and activities in porewater, loosely attached, and firmly attached fractions in permeable surface sediments
Authors: Moncada Chyrene , Arnosti Carol , Brüwer Jan D , de Beer Dirk , Amann Rudolf , Knittel Katrin 
Published: August 2024

Abstract
Heterotrophic microbes are central to organic matter degradation and transformation in marine sediments. Currently, most investigations of benthic microbiomes do not differentiate between processes in the porewater and on the grains and, hence, only show a generalized picture of the community. This limits our understanding of the structure and functions of sediment microbiomes. To address this problem, we fractionated sandy surface sediment microbial communities from a coastal site in Isfjorden, Svalbard, into cells associated with the porewater, loosely attached to grains, and firmly attached to grains; we found dissimilar bacterial communities and metabolic activities in these fractions. Most (84%–89%) of the cells were firmly attached, and this fraction comprised more anaerobes, such as sulfate reducers, than the other fractions. The porewater and loosely attached fractions (3% and 8%–13% of cells, respectively) had more aerobic heterotrophs. These two fractions generally showed a higher frequency of dividing cells, polysaccharide (laminarin) hydrolysis rates, and per-cell O2 consumption than the firmly attached cells. Thus, the different fractions occupy distinct niches within surface sediments: the firmly attached fraction is potentially made of cells colonizing areas on the grain that are protected from abrasion, but might be more diffusion-limited for organic matter and electron acceptors. In contrast, the porewater and loosely attached fractions are less resource-limited and have faster growth. Their cell numbers are kept low possibly through abrasion and exposure to grazers. Differences in community composition and activity of these cell fractions point to their distinct roles and contributions to carbon cycling within surface sediments.
Considerations of monopsony in merger analysis: The Penguin Random House case
Authors: Alderman Brianna L , Blair Roger D 
Published: August 2024

Abstract
In 2020, Bertelsmann SE & Co., the owner of Penguin Random House (PRH), offered to acquire Simon & Schuster for $2.175 billion. If the merger had been consummated, the newly merged firm would have had a 49 per cent share of the market for publishing rights to anticipated top-selling books. Concerned by the proposed merger, the Department of Justice alleged that a more concentrated sector for publishing would result in lower advances to authors of highly anticipated books. The antitrust concern, therefore, centred on the exercise of monopsony power rather than monopoly power. The District Court was persuaded by the evidence presented at trial and blocked the merger on that ground. Having lost at trial, PRH decided to forgo an appeal. This article provides a brief analysis and critique of the District Court’s ruling.
Approaches for predicting dairy cattle methane emissions: from traditional methods to machine learning
Authors: Ross Stephen , Wang Haiying , Zheng Huiru , Yan Tianhai , Shirali Masoud 
Published: August 2024

Abstract
Measuring dairy cattle methane (CH4) emissions using traditional recording technologies is complicated and expensive. Prediction models, which estimate CH4 emissions based on proxy information, provide an accessible alternative. This review covers the different modeling approaches taken in the prediction of dairy cattle CH4 emissions and highlights their individual strengths and limitations. Following the guidelines set out by the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA); Scopus, EBSCO, Web of Science, PubMed and PubAg were each queried for papers with titles that contained search terms related to a population of “Bovine,” exposure of “Statistical Analysis or Machine Learning,” and outcome of “Methane Emissions”. The search was executed in December 2022 with no publication date range set. Eligible papers were those that investigated the prediction of CH4 emissions in dairy cattle via statistical or machine learning (ML) methods and were available in English. 299 papers were returned from the initial search, 55 of which, were eligible for inclusion in the discussion. Data from the 55 papers was synthesized by the CH4 emission prediction approach explored, including mechanistic modeling, empirical modeling, and machine learning. Mechanistic models were found to be highly accurate, yet they require difficult-to-obtain input data, which, if imprecise, can produce misleading results. Empirical models remain more versatile by comparison, yet suffer greatly when applied outside of their original developmental range. The prediction of CH4 emissions on commercial dairy farms can utilize any approach, however, the traits they use must be procurable in a commercial farm setting. Milk fatty acids (MFA) appear to be the most popular commercially accessible trait under investigation, however, MFA-based models have produced ambivalent results and should be consolidated before robust accuracies can be achieved. ML models provide a novel methodology for the prediction of dairy cattle CH4 emissions through a diverse range of advanced algorithms, and can facilitate the combination of heterogenous data types via hybridization or stacking techniques. In addition to this, they also offer the ability to improve dataset complexity through imputation strategies. These opportunities allow ML models to address the limitations faced by traditional prediction approaches, as well as enhance prediction on commercial farms.
Effect of dietary calcium source, exogenous phytase, and formic acid on inositol phosphate degradation, mineral and amino acid digestibility, and microbiota in growing pigs
Authors: Klein Nicolas , Sarpong Naomi , Feuerstein Dieter , Camarinha-Silva Amélia , Rodehutscord Markus 
Published: August 2024

Abstract
The choice of the calcium (Ca) source in pig diets and the addition of formic acid may affect the gastrointestinal inositol phosphate (InsP) degradation and thereby, phosphorus (P) digestibility in pigs. This study assessed the effects of different Ca sources (Ca carbonate, Ca formate), exogenous phytase, and chemical acidification on InsP degradation, nutrient digestion and retention, blood metabolites, and microbiota composition in growing pigs. In a randomized design, 8 ileal-cannulated barrows (24 kg initial BW) were fed 5 diets containing Ca formate or Ca carbonate as the only mineral Ca addition, with or without 1,500 FTU/kg of an exogenous hybrid 6-phytase. A fifth diet was composed of Ca carbonate with phytase but with 8 g formic acid/kg diet. No mineral P was added to the diets. Prececal InsP6 disappearance and P digestibility were lower (P ≤ 0.032) in pigs fed diets containing Ca formate. In the presence of exogenous phytase, InsP5 and InsP4 concentrations in the ileal digesta were lower (P ≤ 0.019) with Ca carbonate than Ca formate. The addition of formic acid to Ca carbonate with phytase diet resulted in greater (P = 0.027) prececal InsP6 disappearance (87% vs. 80%), lower (P = 0.001) InsP5 concentration, and greater (P ≤ 0.031) InsP2 and myo-inositol concentrations in the ileal digesta. Prececal P digestibility was greater (P = 0.004) with the addition of formic acid compared to Ca carbonate with phytase alone. Prececal amino acid (AA) digestibility of some AA was greater with Ca formate compared to Ca carbonate but only in diets with phytase (P ≤ 0.048). The addition of formic acid to the diet with Ca carbonate and phytase increased (P ≤ 0.006) the prececal AA digestibility of most indispensable AA. Exogenous phytase affected more microbial genera in the feces when Ca formate was used compared to Ca carbonate. In the ileal digesta, the Ca carbonate diet supplemented with formic acid and phytase led to a similar microbial community as the Ca formate diets. In conclusion, Ca formate reduced prececal InsP6 degradation and P digestibility, but might be of advantage in regard to prececal AA digestibility in pigs compared to Ca carbonate when exogenous phytase is added. The addition of formic acid to Ca carbonate with phytase, however, resulted in greater InsP6 disappearance, P and AA digestibility values, and changed ileal microbiota composition compared to Ca carbonate with phytase alone.
An Initial Report of Thermal Runaway Resulting in Full-Thickness Foot Burns From Lithium-Ion Battery-Powered Insole
Authors: Cole-Price Ayana K , Silverman Elizabeth , Sienko Peter , Molvik Heather , Vercruysse Gary A 
Published: August 2024

Abstract
Lithium-ion batteries are used in many commercial products such as electronics, cell phones, and e-cigarettes. The use of these batteries has become widespread over recent years due to their chargeability and long-lasting performance. Though a rare occurrence, lithium-ion batteries can fail due to myriad battery defects, which can cause fires and burns. One particular concern is that of thermal runaway, a critical failure marked by a sudden exothermic reaction that occurs as a result of damage to the lithium battery. Thermal runaway can produce heat in excess of 1800 °F, causing severe burns to individuals in close proximity. A 39-year-old man presented to an emergency department (ED) with full-thickness burns to his right foot after an episode of lithium-ion battery thermal runaway in his footwarmer. The patient’s boot suddenly and unexpectedly caught fire for several seconds prior to being successfully removed. The patient subsequently underwent several weeks of debridements, auto- and homografting, and wound care before eventually making a full recovery. This case highlights the rare, but serious, risk posed by lithium-ion batteries as a result of thermal runaway. This phenomenon can cause devastating full-thickness burns in a matter of seconds. As lithium-ion-powered appliances grow in popularity, stringent safety measures should be implemented to prevent catastrophic injuries. Furthermore, healthcare providers should be made aware of injuries caused by thermal runaway to appropriately treat patients.
One-carbon metabolism supports S-adenosylmethionine and m6A methylation to control the osteogenesis of bone marrow stem cells and bone formation
Authors: Zhang Wenjie , Bai Yujia , Hao Lili , Zhao Yiqing , Zhang Lujin , Ding Wenqian , Qi Yipin , Xu Qiong 
Published: August 2024

Abstract
The skeleton is a metabolically active organ undergoing continuous remodeling initiated by bone marrow stem cells (BMSCs). Recent research has demonstrated that BMSCs adapt the metabolic pathways to drive the osteogenic differentiation and bone formation, but the mechanism involved remains largely elusive. Here, using a comprehensive targeted metabolome and transcriptome profiling, we revealed that one-carbon metabolism was promoted following osteogenic induction of BMSCs. Methotrexate (MTX), an inhibitor of one-carbon metabolism that blocks S-adenosylmethionine (SAM) generation, led to decreased N6-methyladenosine (m6A) methylation level and inhibited osteogenic capacity. Increasing intracellular SAM generation through betaine addition rescued the suppressed m6A content and osteogenesis in MTX-treated cells. Using S-adenosylhomocysteine (SAH) to inhibit the m6A level, the osteogenic activity of BMSCs was consequently impeded. We also demonstrated that the pro-osteogenic effect of m6A methylation mediated by one-carbon metabolism could be attributed to HIF-1α and glycolysis pathway. This was supported by the findings that dimethyloxalyl glycine rescued the osteogenic potential in MTX-treated and SAH-treated cells by upregulating HIF-1α and key glycolytic enzymes expression. Importantly, betaine supplementation attenuated MTX-induced m6A methylation decrease and bone loss via promoting the abundance of SAM in rat. Collectively, these results revealed that one-carbon metabolite SAM was a potential promoter in BMSC osteogenesis via the augmentation of m6A methylation, and the cross talk between metabolic reprogramming, epigenetic modification, and transcriptional regulation of BMSCs might provide strategies for bone regeneration.
Correction by distraction: how high-tempo music enhances medical experts’ debunking TikTok videos
Authors: Li Mengyu , Li Gaofei , Yang Sijia 
Published: August 2024

Abstract
The spread of multimodal coronavirus disease 2019 (COVID-19) misinformation on social media poses considerable public health risks. Yet limited research has addressed the efficacy of citizen-contributed, multimodal debunking messages, especially the roles of audiovisual structural features. In a between-subject online experiment, we assessed the impacts of misleading TikTok videos promoting the false claim that COVID-19 vaccines cause infertility and compared the effectiveness of debunking videos from medical experts vs. laypeople. We independently varied the presence of background music. Results showed that while misleading TikTok videos increased misperceptions, most debunking videos effectively countered such misinformation. Notably, compared with laypeople’s testimonial corrections, expert didactic videos benefited more from incorporating high-tempo background music, primarily through the suppression of counterarguing rather than through enhanced encoding. These findings underscore the importance to consider audiovisual structural features, such as background music, as well as the cognitive pathway through distracted counterarguing, in future research on multimodal misinformation and correction.
Beyond “buzz”: knowledge interactions, innovation, and neighborhood characteristics
Authors: Matsiuk Nadiia , Doloreux David , Shearmur Richard 
Published: August 2024

Abstract
We examine the link between neighborhood characteristics, the importance of knowledge exchange, and firm innovation in Montreal. To this end we combine two sources of data: place-of-residence census data from Statistics Canada and the results of an original firm survey. Through principal component analysis and subsequent clustering, we define five types of neighborhoods. The results revealed that firms assign higher importance to local knowledge exchange when located in dense, walkable neighborhoods with higher educated residents. Knowledge exchange, both local and global, correlates with incremental and radical innovation. Moreover, firms are innovative in any neighborhood, provided they engage in knowledge exchange.
Model-based abductive cognition: What thought experiments teach us
Authors: Magnani Lorenzo , Arfini Selene 
Published: August 2024

Abstract
In this article, we want to demonstrate how thoughts experiments (TEs) incorporate cognitive structures—abductive inferences as conceptual metaphors—that reliably underpin everyday thinking and are enhanced and rendered more effective in scientific and philosophical contexts. Indeed one might successfully rethink the inferential structure at the heart of thought experiment production as the application of a generative abductive procedure. We shall characterize TES as possessing two characteristics that are essential to the definitions of abductive and metaphorical thinking, but when considered in relation to TE’s description, can excuse mild bewilderment: both knowledge-enhancing and ignorance-preserving features. In sum, we will say that TEs realize extended conceptual metaphors, which instantiate forms of abductive reasoning and, therefore, partially preserve the ignorance of the authors who produce them (even if they also increase a bit their knowledge by—so to speak—mitigating ignorance). In certain fortunate and exceptional instances, however, TEs can also provide a purely knowledge-enhancing benefit; in order to do this, a reference to the innovative and creative function of thought experiments in Galileo’s findings is also included.
Ambient ultraviolet A, ultraviolet B, and risk of melanoma in a nationwide United States cohort, 1984-2014
Authors: Cahoon Elizabeth K , Mandal Soutrik , Pfeiffer Ruth M , Wheeler David C , Sargen Michael R , Alexander Bruce H , Kitahara Cari M , Linet Martha S , Mai Jim Z 
Published: August 2024

Abstract

Background
Ultraviolet radiation (UVR) exposure is the primary risk factor for melanoma, although the relationship is complex. Compared with radiation from UVB wavelengths, UVA makes up a majority of the surface solar UVR, penetrates the skin more deeply, is the principal range emitted by tanning beds, and is less filtered by sunscreens and window glass. Few studies have examined the relationship between ambient UVA and UVB and melanoma risk.

Methods
Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated for the association between satellite-based ambient (based on residential history) UVA, UVB, and melanoma in non-Hispanic White participants using data from the United States Radiologic Technologists study, a large, nationwide prospective cohort. Associations of UVA and UVB quartile (Q) were examined in mutually adjusted and stratified models, additionally adjusted for demographic and sun sensitivity characteristics.

Results
There were 837 incident melanoma cases among 62 785 participants. Incidence of melanoma was statistically significantly increased for the highest quartile of childhood UVA exposure after adjustment for UVB (IRR = 2.82; 95% CI = 1.46 to 5.44) but not for higher childhood UVB after adjustment for UVA. Childhood UVA was associated with increased melanoma risk within strata of UVB. Childhood UVB was not associated with melanoma after adjustment for UVA, but there was some evidence of lower risk with increased lifetime ambient UVB after UVA adjustment.

Conclusions
Melanoma risk was elevated among participants living in locations with high annual childhood and lifetime UVA after controlling for UVB. With confirmation, these findings support increased protection from solar UVA for melanoma prevention.
Keeping Fake Simple
Authors: Guerrini Janek 
Published: August 2024

Abstract
In this paper, I argue against two common claims about so-called privative adjectives like ‘fake’: first, I argue against the idea that their semantic complexity requires a richer notion of lexical meaning than the standard one (see, e.g., Del Pinal, 2018); second, I argue against the idea that ‘fake’ is a subsective adjective ‘in disguise’ and does not semantically negate its input (see, e.g., Partee, 2010). I propose that a fake P is (i) intended to resemble a P and (ii) is not a P. This makes correct predictions for multiple applications of ‘fake’, a task at which other theories fail. In cases of double application of ‘fake’, the interaction between its conjunctive meaning and the negation hard-coded into clause (ii) yields a complex meaning, compatible with a variety of objects, which aligns with intuitions about what should count as a fake N. While the core meaning of ‘fake’ is quite simple, its mode of composition bears some complexity. In line with Martin (2022), I propose that ‘fake’ can alternatively (a) combine directly with the noun via Functional Application or (b) saturate its property argument via an implicit, contextually provided variable via Functional Application and then combine with the noun via Predicate Modification. Mode of composition (a) is clearly visible in syntactic parses that only allow for Functional Application: for instance, in Italian, if pre-nominal, ‘fake’ can only directly take the noun as an input (cf. Cinque, 2010). Positing (b) correctly predicts readings where ‘fake’ is not apparently privative: ‘fake watch’ can designate a watch that is made to resemble a Rolex but isn’t one, i.e. a fake(-as-a-Rolex) watch. When the intersection between the $[\![ \mathit{fake} ]\!] (*\mathit{implicit\ argument}*)$ complex and the noun is empty, rescuing principles originally proposed by Partee kick in to rescue from vacuous modification: this explains why we can refer to a fake gun as a gun, as in the sentence ‘this gun is fake’. As a result, besides correctly predicting iterated ‘fake’, this theory provides clear predictions on when and how Partee’s pragmatic principles of noun modulation apply. I conclude the paper arguing that this view of privatives calls for a classification of adjectives in terms of their mode of composition, rather than in terms of their emergent entailment pattern.