bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pendapatan Petani Tomat di Desa Done Kecamatan Magepanda, Nusa Tenggara Timur
Authors: Wara Wilfridus , Syurun Muhamad , Hereng Rusli 
Published: August 2024

Penelitian ini bertujuan untuk Untuk mengetahui pendapatan petani tomat di Desa Done Kecamatan Magepanda dan Untuk mengetahui faktor penghambat pendapatan petani tomat. Metode penelitian yang digunakan adalah deskriptif kualitatif. Penelitian ini di lakukan di desa done kecamatan magepanda Kabupaten Sikka. Dengan memiliki sumber data primer dari penelitian ini yakni dari wawancara langsung dengan warga Desa Done dan sekunder yakni dari beberapa sumber buku dan referensi lainnya. Penulis menggunakan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi. Untuk menganalisis data penulis menggunakan triangulasi. Data yang diperoleh dari penelitian ini berdasarkan luas lahan usahatani di Desa Done Kecamatan Mageoanda dengan luas lahan 1 hektar (100 are). Dalam sekali panen, petani memperoleh 200 kg - 320 kg tomat yang dihasilkan. Hasil yang didapatkan petani dari 200 kg - 320 kg tomat yang dipanen dengan menentukan harga jual sebesar Rp.20.000. Maka total yang didapatkan petani adalah sebesar Rp.4.000.000 sampai Rp.6.000.000. Yang menjadi faktor penghambat pada pendapatan petani tomat di Desa Done Kecamatan Mageoanda yaitu: Kendala abiotik yang mencakup banjir, irigasi, ketersediaan air, hujan, cuaca dan kesuburan tanah; Kendala pada teknologi dan agronomi seperti: kualitas benih, kualitas buah tomat, produktivitas yang rendah, metode bercocok tanam yang tidak efektif, ketersediaan pupuk dan pestisida; dan Tantangan biotik, seperti serangan hama penyakit.
Identification of the molecular link: STAT3 is a shared key gene linking postmenopausal osteoporosis and sarcopenia
Authors: Liu Dian , Wang Ke , Wang Jinpeng , Cao Fangming , Tao Lin 
Published: August 2024

AimsThis study explored the shared genetic traits and molecular interactions between postmenopausal osteoporosis (POMP) and sarcopenia, both of which substantially degrade elderly health and quality of life. We hypothesized that these motor system diseases overlap in pathophysiology and regulatory mechanisms.MethodsWe analyzed microarray data from the Gene Expression Omnibus (GEO) database using weighted gene co-expression network analysis (WGCNA), machine learning, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to identify common genetic factors between POMP and sarcopenia. Further validation was done via differential gene expression in a new cohort. Single-cell analysis identified high expression cell subsets, with mononuclear macrophages in osteoporosis and muscle stem cells in sarcopenia, among others. A competitive endogenous RNA network suggested regulatory elements for these genes.ResultsSignal transducer and activator of transcription 3 (STAT3) was notably expressed in both conditions. Single-cell analysis pinpointed specific cells with high STAT3 expression, and microRNA (miRNA)-125a-5p emerged as a potential regulator. Experiments confirmed the crucial role of STAT3 in osteoclast differentiation and muscle proliferation.ConclusionSTAT3 has emerged as a key gene in both POMP and sarcopenia. This insight positions STAT3 as a potential common therapeutic target, possibly improving management strategies for these age-related diseases.Cite this article: Bone Joint Res 2024;13(8):411–426.
The impact of comprehensive geriatric assessment on postoperative outcomes in elderly surgery: A systematic review and meta-analysis
Authors: Chen Lin , Zong Wei , Luo Manyue , Yu Huiqin 
Published: August 2024

Introduction
The elderly population experiences more postoperative complications. A comprehensive geriatric assessment, which is multidimensional and coordinated, could help reduce these unfavorable outcomes. However, its effectiveness is still uncertain.

Methods
We searched multiple online databases, including Medline, PubMed, Web of Science, Cochrane Library, Embase, CINAL, ProQuest, and Wiley, for relevant literature from their inception to October 2023. We included randomized trials of individuals aged 65 and older undergoing surgery. These trials compared comprehensive geriatric assessment with usual surgical care and reported on postoperative outcomes. Two researchers independently screened the literature, extracted data, and assessed the certainty of evidence from the identified articles. We conducted a meta-analysis using RevMan 5.3 to calculate the Odds Ratio (OR) and Mean Difference (MD) of the pooled data.

Results
The study included 1325 individuals from seven randomized trials. Comprehensive geriatric assessment reduced the rate of postoperative delirium (28.5% vs. 37.0%; OR: 0.63; CI: 0.47–0.85; I2: 54%; P = 0.003) based on pooled data. However, it did not significantly improve other parameters such as length of stay (MD: -0.36; 95% CI: -0.376, 3.05; I2: 96%; P = 0.84), readmission rate (18.6% vs. 15.4%; OR: 1.26; CI: 0.86–1.84; I2: 0%; P = 0.24), and ADL function (MD: -0.24; 95% CI: -1.27, 0.19; I2: 0%; P = 0.64).

Conclusions
Apart from reducing delirium, it is still unclear whether comprehensive geriatric assessment improves other postoperative outcomes. More evidence from higher-quality randomized trials is needed.
Electrolytes as predictors of fibro fatigue scores in Long-COVID patients
Authors: Al Masoodi Wasim Talib Mahdi , Radhi Sami Waheed , Al-Hakeim Hussein Kadhem , Abdalsada Habiba Khdair 
Published: August 2024

Background
The complex effects of Long-COVID, a syndrome marked by enduring symptoms after COVID-19 infection, with an emphasis on patients’ differing degrees of fibro fatigue (FF). Electrolyte disturbances may affect the severity of FF and may be used as a predictive tool for severe FF in Long-COVID patients.

Objective
The aim is to use the electrolyte levels for prediction of the Long-COVID patients with high FF levels.

Methods
The electrolyte levels, calcium, and magnesium, as well as albumin and C-reactive protein levels were measured in 120 Long-COVID patients and 60 controls. FF scale was used for scoring the fatigue severity in all subjects. Patients were divided into high-FF (FF score>25) and moderate-FF group (FF score<25).

Results
FF is the major effector on the serum biomarker levels. High-FF group had older people, longer disease durations, lower SpO2, higher CRP, and higher peak temperatures than the control group. High-FF group has a significant decrease in serum total and ionized calcium compared with the controls and low-FF group. After controlling the cofounders, the major factor controlling the levels of the measured biomarkers is the FF value (Partial η2 = 0.468). The ROC-AUC analysis showed that the peak body temperature, Low-SpO2, high-CRP, and low electrolytes can predict the high-FF in a patient with Long-COVID with a moderate sensitivity and specificities (61.6–70%).

Conclusion
Long-COVID patients have an elevation in FF score. The decline in electrolytes can predict the severity of FF with moderate sensitivities and specificities.
A comparative analysis of weekly internal and external workloads between starting and non-starting professional soccer players: A retrospective 21-week examination
Authors: Kunz Philipp , Düking Peter , Sperlich Billy 
Published: August 2024

Objectives
Aims of the present investigation encompassed: (i) the quantification of training and match loads experienced by starters and non-starters within a professional soccer team; (ii) the identification of variations in these loads across different training modalities, namely, Preparation Training (PT), Match and Match Compensation Training (M&MCT), and their cumulative sum (Total Load; TL); and (iii) the formulation of guidelines aimed at harmonizing the weekly workloads between the groups.

Methods
Internal and external load of training sessions (n = 97), competitive matches (n = 21) and running based sessions (n = 4) were recorded for 21 weeks to investigate possible heterogeneity between starters and non-starters across PT, M&MCT and TL.

Results
During PT, time spent in heart rate zone 5 (HRZ5) was increased for non-starters (+46.1%). During M&MCT, lower loads for non-starters were found in the rate of perceived exertion (sRPE) (-45.6%), HRZ4 (-54%) and HRZ5 (-77.8%), total distance (TD) (-37%), number of sprints (-58.1%), distance in speed zone 1 (-51.1%), zone 3 (-61.5%) and zone 4 (-59.8%) (SZ1, SZ3&4) and all acceleration and deceleration zones (Acc1-4; Dec1-4) (Acc1: -53.1%; Acc2: -56.3%; Acc3: -59.2%; Acc4: 57.8%) (Dec1: -45.9%; Dec2: -55.2%; Dec3: -63.2%; Dec4: -67.7%). Regarding TL, the non-starters’ loads remain lower compared to starters for sRPE (-19.2%), HRZ4 (-21.6%) and HRZ5 (-41.4%), number of sprints (-26.7%), SZ3 (-34.2%), Acc3 (-24.4%), Acc4 (-26.1%), Dec2 (-18.7%), Dec3 (-24%) and Dec4 (-31.2%).

Conclusions
By implementing a running-based regimen on matchday and MCT the day after (MD+1), TD, distances in SZ1, SZ2, SZ4, SZ5, and counts of accelerations in Acc1&2, as well as Dec1, were effectively replicated for non-starters. All other variables remained unaligned for the non-starters. Given the prevalent emphasis on Small-Sided Games (SSGs) during MCT at MD+1, the incorporation of an additional running-based session for non-starters on MD is advised to address gaps in TD, sprint counts, and high-intensity load variables, such as HRZ4&5 and SZ 3 to 5.
California & Hawai’i Bound: U.S. Settler Colonialism & the Pacific West, 1848–1959, Henry Knight Lozano (2022)
Authors: Srivastava Saloni 
Published: August 2024

Review of: California & Hawai’i Bound: U.S. Settler Colonialism & the Pacific West, 1848–1959, Henry Knight Lozano (2022)
Lincoln, NE: University of Nebraska Press, pp. 416.,
ISBN 978-1-49621-213-9, h/bk, $65.00
Drawing from the Archives: Comics Memory in the Contemporary Graphic Novel, Benoît Crucifix (2023)
Authors: de Adana Francisco Sáez , Van de Wiele Eva 
Published: August 2024

Review of: Drawing from the Archives: Comics Memory in the Contemporary Graphic Novel, Benoît Crucifix (2023)
Cambridge: Cambridge University Press, 246 pp.,
ISBN 978-1-00925-095-5, e-book, €99.20
Nonlinear elliptic unilateral problems with measure data in the anisotropic Sobolev space
Authors: Bouzelmate Arij , El Haji Badr , Lamtarah Adnan 
Published: August 2024

Abstract
In this article, we consider a nonlinear elliptic unilateral equation whose model is

−

∑

i
=
1

N

∂

i

σ

i

(

x
,
u
,

∇

u

)

+
L

(

x
,
u
,

∇

u

)

+
N

(

x
,
u
,

∇

u

)

=
μ
−
div
ϕ

(

u

)

in

Ω
.

-\mathop{\sum }\limits_{i=1}^{N}{\partial }^{i}{\sigma }_{i}\left(x,u,\nabla u)+L\left(x,u,\nabla u)+N\left(x,u,\nabla u)=\mu -{\rm{div}}\phi \left(u)\hspace{1.0em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}\Omega .

We prove the existence of entropy solutions for the aforementioned equation in the anisotropic Sobolev space, under the hypotheses,

μ
=
f
−
div
F

\mu =f-{\rm{div}}F

belongs to

L

1

(

Ω

)

+

W

−
1
,

p

′

(

Ω

)

{L}^{1}\left(\Omega )+{W}^{-1,{p}^{^{\prime} }}\left(\Omega )

. The nonlinear terms

L

(

x
,
s
,

∇

u

)

L\left(x,s,\nabla u)

satisfy the sign and growth conditions, and

N

(

x
,
s
,

∇

u

)

N\left(x,s,\nabla u)

verifies only the growth conditions.
Toward sustainability: Integrating experimental study and data-driven modeling for eco-friendly paver blocks containing plastic waste
Authors: Asif Usama , Javed Muhammad Faisal , Alsekait Deema Mohammed , AbdElminaam Diaa Salama , Alabduljabbar Hisham 
Published: August 2024

Abstract
Plastic waste (PW) poses a significant threat as a hazardous material, while the production of cement raises environmental concerns. It is imperative to urgently address and reduce both PW and cement usage in concrete products. Recently, several experimental studies have been performed to incorporate PW into paver blocks (PBs) as a substitute for cement. However, the experimental testing is not enough to optimize the use of waste plastic in pavers due to resource and time limitations. This study proposes an innovative approach, integrating experimental testing with machine learning to optimize PW ratios in PBs efficiently. Initially, experimental investigations are performed to examine the compressive strength (CS) of plastic sand paver blocks (PSPBs). Varied mix proportions of plastic and sand with different sizes of sand are employed. Moreover, to enhance the CS and meet the minimum requirements of ASTM C902-15 for light traffic, basalt fibers, a sustainable industrial material, are also utilized in the manufacturing process of environmentally friendly PSPB. The highest CS of 17.26 MPa is achieved by using the finest-size sand particles with a plastic-to-sand ratio of 30:70. Additionally, the inclusion of 0.5% basalt fiber, measuring 4 mm in length, yields further enhancement in outcome by significantly improving CS by 25.4% (21.65 MPa). Following that, an extensive experimental record is established, and multi-expression programming (MEP) is used to forecast the CS of PSPB. The model’s projected results are confirmed by using various statistical procedures and external validation methods. Furthermore, comprehensive parametric and sensitivity studies are conducted to assess the effectiveness of the MEP-based proposed models. The sensitivity analysis demonstrates that the size of the sand particles and the fiber content are the primary factors contributing to more than 50% of the CS in PSPB. The parametric analysis confirmed the model’s accuracy by demonstrating a comparable pattern to the experimental results. Furthermore, the results indicate that the proposed MEP-based formulation exhibits high precision with an R
2 of 0.89 and possesses a strong ability to predict. The study also provides a graphical user interface to increase the significance of ML in the practical application of handling waste management. The main aim of this research is to enhance the reuse of PW to promote sustainability and economic benefits, particularly in producing green environments with integration of machine learning and experimental investigations.
The association between BMI and BRAFV600E mutation may differ by primary tumor size
Authors: Park Hyunju , Heo Jung , Ryu Hyun Jin , Kim Min-Ji , Oh Young Lyun , Kim Tae Hyuk , Kim Sun Wook , Chung Jae Hoon 
Published: August 2024

Objective
Previous reports suggest that a high body mass index (BMI) increases the risk of thyroid carcinoma. However, it remains unclear whether a high BMI is associated with the risk of the BRAFV600E mutation. We aimed to assess whether a high BMI is associated with an increased risk of the BRAFV600E mutation.

Design and Methods
We screened 6558 PTC patients who had undergone BRAFV600E mutation testing between January 2009 and December 2017. After exclusion, 6438 PTC patients were enrolled. We used logistic regression, and restricted cubic spline plots of the adjusted odds ratios (ORs) were illustrated to model the relationship between BMI and the BRAFV600E mutation.

Results
Of the 6438 patients, 5102 (79.2%) had the BRAFV600E mutation, and 4954 (76.9%) were female. The median BMI was 23.8 (21.6–26.2) kg/m2. The primary tumor size was ≤1 cm in 4226 patients (65.6%) and >1 cm in 2212 patients (34.4%). The BRAFV600E mutation was significantly associated with high BMI only in patients with a primary tumor size >1 cm (OR: 1.034; 95% CI: 1.003–1.065; P = 0.029), whereas no clear association was found in patients with a primary tumor size ≤1 cm (OR: 1.007; 95% CI: 0.984–1.030; P = 0.570). Gender was not a significant factor in either group.

Conclusions
Our study found that a higher BMI was positively associated with the BRAFV600E mutation in patients with a primary tumor size >1 cm. These results suggest that the association between BMI and the BRAFV600E mutation status differs depending on primary tumor size.

Significance Statement
Obesity has been suggested as a potential risk factor for thyroid carcinoma. The aim of this study was to assess the association between BMI and the BRAFV600E mutation. In this study, the BRAFV600E mutation was significantly associated with a high BMI only in a primary tumor size >1 cm (OR: 1.034; P = 0.029). No clear association was found in patients with a primary tumor size ≤1 cm (OR: 1.007; P = 0.570). The association between BMI and the BRAFV600E mutation status differs depending on the primary tumor size.
Trends in HIE and Use of Hypothermia in California: Opportunities for Improvement
Authors: Bonifacio Sonia Lomeli , Liu Jessica , Lee Henry C. , Hintz Susan R. , Profit Jochen 
Published: August 2024

BACKGROUND AND OBJECTIVES
Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal morbidity and mortality. Therapeutic hypothermia (TH), a proven treatment of moderate–severe HIE, was first used clinically after 2006. We describe trends in HIE diagnosis and use of TH over a 10-year period in California.

METHODS
We identified 62 888 infants, ≥36 weeks gestation, who were cared for in California Perinatal Quality Care Collaborative-participating NICUs between 2010 and 2019, and linked them to birth certificate data. We evaluated trends in HIE diagnosis and use of TH.

RESULTS
Over time, rates of HIE diagnosis increased from 0.6 to 1.7 per 1000 live births, and use of TH increased from 26.5 to 83.0 per 1000 infants. Rates of moderate HIE increased more than mild or severe, although use of TH for mild HIE increased more than for moderate. Of those with moderate–severe HIE, 25% remain untreated. Treatment varied by NICU level of care.

CONCLUSIONS
The rates of HIE and TH increased steadily. Some infants with moderate–severe HIE remain untreated, suggesting a need for ongoing education. Further evaluation of systems of care is needed to assure all qualifying infants are treated.
Rural activity spaces integration with creative market models
Authors: Wu Mengyang 
Published: August 2024

AbstractAs urbanization advances and societal shifts unfold, the integration of rural development and activity spaces has become a focal point in academic discourse. This study aims to explore the synergistic effects of the creative market model on rural activity spaces, dissecting its role in shaping these spaces, enhancing community engagement, and generating socio-economic benefits. Empirical findings highlight the affirmative role of the creative market model in this fusion. The research on community participation and spatial design reveals how creative markets enhance residents' sense of involvement and explores the influence of activity space design on community interaction. This study, by thoroughly examining the integration of the creative market model and rural activity spaces, offers theoretical and empirical support for advancing rural development.
High urine sodium/potassium ratio, high LDL/HDL ratio, high level of serum F2-isoprostane, and low level of microtubule-associated protein 1a/1b-light chain 3b (LC3B) as risk factors of preeclampsia
Authors: Widiyanti Endang Sri , Kusuma Anak Agung Ngurah Jaya , Wande I Nyoman , Leonardi Monica , Wibawa I Gusti Ngurah Agung Satria 
Published: August 2024

Background: Preeclampsia (PE), still a major health concern which is related to high maternal mortality and morbidity rates. It is historically correlated with early oxidative stress and autophagy dysfunction, prompting this study to investigate the potential risk factors of PE, including high level of urine sodium/potassium (Na/K) ratio, low-density lipoprotein to high-density lipoprotein (LDL/HDL) ratio, elevated serum F2-Isoprostane levels (F2-IsoPS), and diminished serum microtubule-associated protein 1a/1b-light chain 3b (LC3B).
Methods: This is a case-control study, conducted at Prof. Dr. I.G.N.G Ngoerah General Hospital from June to September 2023, including 25 pregnant women with preeclampsia (PE) as cases and 25 without PE as controls. The study analyses urine sodium and potassium levels, serum LDL and HDL levels, LC3B, and F2-isoprostane levels using the Enzyme-linked Immunoassay (ELISA) method. Statistical analysis was conducted using IBM SPSS Statistics Version 25 software.
Results: High urine sodium/potassium ratio (>3.95), high serum LDL/HDL Ratio (>2.6), high serum F2-Isoprostane levels (>476.24 ng/mL), and low serum LC3B levels (<291.975 ng.mL) was found to be a significant risk factor for preeclampsia, with an OR of 11.16 (p < 0.001; 95% CI = 2.86 – 43.46); OR= 23.222 (p < 0.001; 95% CI = 5.101 – 105.728); OR= 38.5 (p=0.000; 95% CI: 7.681-192.985); and OR=8.143 (p=0.001; 95% CI: 2.294-28.901) respectively. Based on multivariate analysis, the variables that contribute mainly to the occurrence of PE, from the highest, respectively, are high LDL/HDL ratio, high level of F2-IsoPs, low level of serum LC3B, and high urine Na/K ratio (OR=149.96; OR=95.43; OR=36.11; and OR=12.71).
Conclusion: High LDL/HDL ratio, high level of F2-Isoprostanes serum, low level of serum LC3B, and high urine Na/K ratio are risk factors for preeclampsia.
The role of methionine in tuberculosis and its potential clinical significance
Authors: Sari Putu Suwita , Mas Rizky A A Syamsunarno  , Chaidir Lidya 
Published: August 2024

Tuberculosis (TB) remains a significant global health challenge. Multidrug-resistant tuberculosis (MDR-TB) holds a substantial health risk, and only a limited number of patients receive treatment for drug-resistant tuberculosis. Various studies have been conducted to address this condition, including through metabolic approaches to further understand the mechanisms of tuberculosis infection, one of which is methionine. There are various enzymes in the Mycobacterium tuberculosis (MTB) methionine biosynthesis pathway, the key enzymes such as MetX, MetC, MetE/MetH, MetK, MTHFR, and BCAT are essential in the biosynthesis of methionine, and hindering these enzyme activities may hold potential for new antitubercular drug development. Deletion of the metA gene weakens MTB, making it more prone to host immune responses. There is also the role of cobalamin, where cobalamin availability regulates the choice between metE and metH in methionine biosynthesis. Methionine plays a crucial role in bacterial protein translation and antioxidant activities. In bacteria including MTB, the initial methionine is formulated; this process involves several enzymes such as FMT, MetRS, PDF, and MetAP. Some compounds targeting MetAP have been identified to have significant inhibitory action against MTB, such as transitmycin and bengamides, and this also includes the drug resistant strain. Methionine supplementation alongside vitamin B-complex have shown to improve drug-induced toxicity in tuberculosis patients, this due to methionine serves as precursor to antioxidant glutathione. Metabolomics studies have shown that altered methionine levels in tuberculosis infection, with samples taken from human blood or urine show significantly lower levels in patients with active TB or failed treatment groups. This review aims to discuss the role of methionine in Mycobacterium tuberculosis and the progress of research targeting methionine metabolism and function.