bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dialysis Modality and Correction of Uremic Metabolic Acidosis
Authors: Vashistha Tania , Kalantar-Zadeh Kamyar , Molnar Miklos Z. , Torlén Klara , Mehrotra Rajnish 
Published: November 2012

Summary

Background and objectives
Uremic metabolic acidosis is only partially corrected in many hemodialysis patients, and low serum bicarbonate predicts higher death risk. This study determined the comparative efficacy of peritoneal dialysis in correcting uremic metabolic acidosis and the association of serum bicarbonate and death risk with the two therapies.

Design, setting, participants, & measurements
Data were obtained from 121,351 prevalent ESRD patients (peritoneal dialysis, 10,400; hemodialysis, 110,951) treated in DaVita facilities between July 1, 2001 and June 30, 2006, with follow-up through June of 2007.

Results
Serum bicarbonate was <22 mEq/L in 25% and 40% of peritoneal dialysis and hemodialysis patients, respectively. Thus, peritoneal dialysis patients were substantially less likely to have lower serum bicarbonate (adjusted odds ratio<20 mEq/L, 0.45 [0.42, 0.49]; <22 mEq/L, 0.41 [0.39, 0.43]). Time-averaged serum bicarbonate<19 mEq/L was associated with an 18% and 25% higher risk for all-cause and cardiovascular mortality, respectively, in prevalent peritoneal dialysis patients (reference group: serum bicarbonate between 24 and <25 mEq/L). In analyses using the entire cohort of peritoneal dialysis and hemodialysis patients, the adjusted risk for all-cause mortality was higher in most subgroups with serum bicarbonate<22 mEq/L, irrespective of dialysis modality.

Conclusions
The measured bicarbonate is significantly higher in peritoneal dialysis patients, suggesting that the therapy provides a more complete correction of metabolic acidosis than intermittent hemodialysis. Survival data suggest maintaining serum bicarbonate>22 mEq/L for all ESRD patients, irrespective of dialysis modality.
Effect of Spironolactone and Amiloride on Thiazolidinedione-Induced Fluid Retention in South Indian Patients with Type 2 Diabetes
Authors: Viswanathan Vijay , Mohan Viswanathan , Subramani Poongothai , Parthasarathy Nandakumar , Subramaniyam Gayathri , Manoharan Deepa , Sundaramoorthy Chandru , Gnudi Luigi , Karalliedde Janaka , Viberti Giancarlo 
Published: November 2012

Summary

Background and objectives
Thiazolidinediones (pioglitazone and rosiglitazone) induce renal epithelial sodium channel (ENaC)–mediated sodium reabsorption, resulting in plasma volume (PV) expansion. Incidence and long-term management of fluid retention induced by thiazolidinediones remain unclear.

Design, setting, participants, & measurements
In a 4-week run-in period, rosiglitazone, 4 mg twice daily, was added to a background anti-diabetic therapy in 260 South Indian patients with type 2 diabetes mellitus. Patients with PV expansion (absolute reduction in hematocrit in run-in, ≥1.5 percentage points) entered a randomized, placebo-controlled study to evaluate effects of amiloride and spironolactone on attenuating rosiglitazone-induced fluid retention. Primary endpoint was change in hematocrit in each diuretic group versus placebo (control group).

Results
Of the 260 patients, 70% (n=180) had PV expansion. These 180 patients (70% male; mean age, 47.8 years [range, 30–80 years]) were randomly assigned to rosiglitazone, 4 mg twice daily, plus spironolactone, 50 mg once daily; rosiglitazone, 4 mg twice daily, plus amiloride, 10 mg once daily; or rosiglitazone, 4 mg twice daily, plus placebo for 24 weeks. Hematocrit continued to decrease significantly in control and spironolactone groups (mean absolute change, −1.2 [P=0.01] and −0.7 [P=0.02] percentage points, respectively), suggesting continued PV expansion. No change occurred with amiloride (mean change, 0.0 percentage points). Amiloride, but not spironolactone, was superior to control (mean hematocrit difference [95% confidence interval] relative to control, 1.27 [0.21–2.55] and 0.49 [−0.79–1.77] percentage points [P=0.04 and P=0.61], respectively).

Conclusions
Prevalence of rosiglitazone-induced fluid retention in South Indian patients with type 2 diabetes is high. Amiloride, a direct ENaC blocker, but not spironolactone, prevented protracted fluid retention in these patients.
Le continuum des représentations sexuelles dans le film « 10 » (1979) de Blake Edwards : du baiser amoureux au sexe explicite pour le plaisir
Authors: Lieutenant-Duval Verushka 
Published: November 2012

Résumé L’étude de la représentation de la sexualité dans le film « 10 » (1979) de Blake Edwards fait apparaître un lien entre la présence et l’absence de l’amour romantique et la construction d’un sexe cinématographique plus ou moins vertueux. Nous voyons comment la sexualité à l’écran est organisée entre deux pôles qui opposent le « bon » sexe (celui qui se résume au baiser et où il y a présence d’amour) au « mauvais » sexe (celui qui est explicite et seulement pour le plaisir).
L'« exotisme de la proximité » : l'amour à l'épreuve du monde agricole et du couple
Authors: Béliard Anne-Sophie , Quemener Nelly 
Published: November 2012

Résumé L’émission « L’amour est dans le pré » propose depuis six ans une plateforme de rencontre amoureuse pour des agriculteurs et agricultrices célibataires. Elle présente la spécificité d’entremêler des relations amoureuses à la mise en scène d’un monde jusqu’alors inexploité par la télé-réalité, le milieu agricole. Cette confrontation produit des effets de distanciation et de proximité, tant par rapport aux représentations de l’amour montrées qu’au milieu agricole, que nous proposons d’analyser.
Du romantisme à la relation pure ? Les amours des héroïnes de séries américaines depuis 1950
Authors: Morin Céline 
Published: November 2012

Résumé Les séries télévisées américaines ont dès les années 1950 problématisé les articulations entre modèles amoureux et vagues d’émancipation des femmes. Cet article, centré sur les amours des héroïnes, propose un découpage en trois temps de l’histoire de ces séries, qui tend à montrer que si le romantisme continue de sous-tendre les pratiques, il se trouve confronté à la dissymétrie qu’il provoque entre hommes et femmes et perd du terrain face à la « relation pure », nouvel idéal relationnel. Les femmes au foyer des années 1950 sont soumises à l’insatisfaction de leur condition et laissent transparaître les premiers échecs de l’amour romantique, alors que, deux décennies plus tard, au milieu des années 1990, les working girls célibataires, égéries de l’après-féminisme, constituent l’amour en une menace à leur indépendance et à leur épanouissement. Enfin la récente vague de quadragénaires, veuves ou divorcées, tente de dépasser la contradiction entre indépendance et amour, en pratiquant réellement la « relation pure ».
Le corps sportif dans la presse illustrée pour la jeunesse. L'exemple de la série dessinée Jean-Jacques Ardent Athlète dans le journal Junior (1938-1939)
Authors: Laffage-Cosnier Sébastien , Vivier Christian , Loudcher Jean-François 
Published: November 2012

Résumé En 1936, la Société Parisienne d’Édition lance le journal hebdomadaire de jeunesse Junior pour rivaliser avec l’arrivée des Comics. C’est dans ce contexte de bouleversement de l’édition des illustrés que Pellos (célèbre dessinateur de presse sportive) crée tous les épisodes de Jean-Jacques Ardent dans Junior de 1938 à 1939. Les aventures sportives de Jean-Jacques Ardent Athlète constituent un corpus de 58 planches de bandes dessinées à travers lesquelles le processus créatif du dessinateur consiste à convoquer des mythologies et à mettre en scène le corps athlétique du jeune Ardent idéalisé et façonné à « l’Ecole de la Vie » d’un « sport pur et loyal ». Le jeune lecteur est ainsi invité à devenir un homme par le sport. Plus encore, loin de prôner le retour à une tradition gymnique qu’il juge dépassée, Pellos, en ancien sportif, invite son lectorat à entrer dans l’univers le plus à même de fabriquer un homme idéal à travers une forme assez utopique du sport.
Le discours juridique en France et en Angleterre
Authors: Galonnier Bernard 
Published: November 2012

Par certains aspects, le discours juridique semble ne pas connaître de frontières. En France comme en Angleterre, on constate le fréquent recours à un jargon spécifique ainsi que l’emploi d’un registre élevé. De plus, la langue du droit de ces deux pays tend à donner une acception spécifique à certains mots usuels. Enfin, la présence de termes français rappelle le rôle joué par la conquête normande dans l’élaboration du droit anglais. Toutefois, la spécificité du discours juridique en Angleterre est indéniable : la common law a non seulement élaboré des concepts qui lui sont propres mais elle exprime au moyen d’un discours personnalisé et prolixe et par l’intermédiaire d’une langue imagée l’approche pragmatique d’un système de droit fondé non point sur un code abstrait mais sur un raisonnement inductif. Ainsi, cette langue de spécialité est bien l’émanation de l’âme d’un pays et de ses particularismes culturels.
Impact of IgA Constant Domain on HIV-1 Neutralizing Function of Monoclonal Antibody F425A1g8
Authors: Yu Xiaocong , Duval Mark , Lewis Christopher , Gawron Melissa A. , Wang Rijian , Posner Marshall R. , Cavacini Lisa A. 
Published: November 2012

Abstract
With the majority of HIV infections resulting from mucosal transmission, induction of an effective mucosal immune response is thought to be pivotal in preventing transmission. HIV-specific IgA, but not IgG, has been detected in the genital tract, seminal fluid, urethral swabs, urine, and vaginal wash samples of HIV-negative sex workers and HIV-status discordant couples. Purified mucosal and plasma IgA from some individuals with highly exposed, persistently seronegative status can neutralize infection and present cross-clade neutralization activity, though present at low levels. We generated a CD4-induced human mAb, F425A1g8, and characterized the impact of its isotype variants on HIV neutralizing activity. The result showed that, in contrast to little neutralization by the F425A1g8 IgG1 in the absence of sCD4, the IgA1 variant of the Ab displayed significant independent neutralization activity against a range of HIV clade B isolates in the absence of sCD4. Studies of the neutralizing function of IgA isotypes, and the functional relationship between different antigenic epitopes and IgA Abs, may also suggest strategies for the intervention of virus transmission and spread within the mucosa of the host, as well as serve to inform the design of vaccine strategies that may be more effective at preventing mucosal transmission. This research clearly suggests that IgA isotype, because of its unique molecular structure, may play an important role in HIV neutralization.
Linear Scaling Discontinuous Galerkin Density Matrix Minimization Method with Local Orbital Enriched Finite Element Basis: 1-D Lattice Model System
Authors: Lu Tiao , Cai Wei , Xin Jianguo , Guo Yinglong 
Published: November 2012

AbstractIn the first of a series of papers, we will study a discontinuous Galerkin (DG) framework for many electron quantum systems. The salient feature of this framework is the flexibility of using hybrid physics-based local orbitals and accuracy-guaranteed piecewise polynomial basis in representing the Hamiltonian of the many body system. Such a flexibility is made possible by using the discontinuous Galerkin method to approximate the Hamiltonian matrix elements with proper constructions of numerical DG fluxes at the finite element interfaces. In this paper, we will apply the DG method to the density matrix minimization formulation, a popular approach in the density functional theory of many body Schrödinger equations. The density matrix minimization is to find the minima of the total energy, expressed as a functional of the density matrix ρ(r,r′), approximated by the proposed enriched basis, together with two constraints of idempotency and electric neutrality. The idempotency will be handled with the McWeeny’s purification while the neutrality is enforced by imposing the number of electrons with a penalty method. A conjugate gradient method (a Polak-Ribiere variant) is used to solve the minimization problem. Finally, the linear-scaling algorithm and the advantage of using the local orbital enriched finite element basis in the DG approximations are verified by studying examples of one dimensional lattice model systems.
Transient Brown Adipocyte-Like Cells Derive from Peripheral Nerve Progenitors in Response to Bone Morphogenetic Protein 2
Authors: Salisbury Elizabeth A. , Lazard ZaWaunyka W. , Ubogu Eroboghene E. , Davis Alan R. , Olmsted-Davis Elizabeth A. 
Published: November 2012

AbstractPerineurial-associated brown adipocyte-like cells were rapidly generated during bone morphogenetic protein 2 (BMP2)-induced sciatic nerve remodeling in the mouse. Two days after intramuscular injection of transduced mouse fibroblast cells expressing BMP2 into wild-type mice, there was replication of beta-3 adrenergic receptor+ (ADRB3+) cells within the sciatic nerve perineurium. Fluorescence-activated cell sorting and analysis of cells isolated from these nerves confirmed ADRB3+ cell expansion and their expression of the neural migration marker HNK1. Similar analysis performed 4 days after BMP2 delivery revealed a significant decrease in ADRB3+ cells from isolated sciatic nerves, with their concurrent appearance within the adjacent soft tissue, suggesting migration away from the nerve. These soft tissue-derived cells also expressed the brown adipose marker uncoupling protein 1 (UCP1). Quantification of ADRB3-specific RNA in total hind limb tissue revealed a 3-fold increase 2 days after delivery of BMP2, followed by a 70-fold increase in UCP1-specific RNA after 3 days. Expression levels then rapidly returned to baseline by 4 days. Interestingly, these ADRB3+ UCP1+ cells also expressed the neural guidance factor reelin. Reelin+ cells demonstrated distinct patterns within the injected muscle, concentrated toward the area of BMP2 release. Blocking mast cell degranulation-induced nerve remodeling resulted in the complete abrogation of UCP1-specific RNA and protein expression within the hind limbs following BMP2 injection. The data collectively suggest that local BMP2 administration initiates a cascade of events leading to the expansion, migration, and differentiation of progenitors from the peripheral nerve perineurium to brown adipose-like cells in the mouse, a necessary prerequisite for associated nerve remodeling.
Concise Review: Production of Cultured Red Blood Cells from Stem Cells
Authors: Bouhassira Eric E. 
Published: November 2012

AbstractIn the Western world, the volunteer-based collection system covers most transfusion needs, but transient shortages regularly develop and blood supplies are vulnerable to potentially major disruptions. The production of cultured red blood cells from stem cells is slowly emerging as a potential alternative. The various cell sources, the niche applications most likely to reach the clinic first, and some of the remaining technical issues are reviewed here.
La liberté d’expression est-elle en phase avec l’action syndicale ?
Authors: Verge Pierre 
Published: November 2012

L’article qui suit propose un aperçu d’ensemble de la protection juridique de la liberté d’expression en milieu syndical. S’applique-t-elle non seulement aux moyens usuels d’expression, mais également aux modes qui sont propres au syndicat, comme le piquetage ou la grève ? L’auteur fait aussi une examen de sa portée, d’abord à l’encontre d’une loi qui restreindrait la liberté d’expression syndicale, et ensuite dans la sphère des rapports privés régis par le droit commun.
Cependant, la liberté d’expression s’affirme en outre à l’intérieur de l’institution syndicale. En particulier, le salarié peut-il s’en réclamer à l’encontre de l’obligation légale de participer également aux frais du syndicat ou, encore, dans le cas fréquent d’une disposition conventionnelle l’obligeant à appartenir au groupement ?
Tracking US Health Care Spending by Health Condition and County
Authors: Dieleman Joseph L. , Beauchamp Meera , Crosby Sawyer W. , DeJarnatt Drew , Johnson Emily K. , Lescinsky Haley , McHugh Theresa , Pollock Ian , Sahu Maitreyi , Swart Vivianne , Taylor Kayla V. , Thomson Azalea , Tsakalos Golsum , Weil Maxwell , Wilner Lauren B. , Bui Anthony L. , Duber Herbert C. , Haakenstad Annie , Idrisov Bulat , Mokdad Ali , Naghavi Mohsen , Roth Gregory , Scott John W. , Templin Tara , Murray Christopher J. L. 
Published: February 2025

ImportanceUnderstanding health conditions with the most spending and variation across locations and over time is important for identifying trends, highlighting inequalities, and developing strategies for lowering health spending.ObjectiveTo estimate US health care spending for each of 3110 US counties, across 4 payers (Medicare, Medicaid, private insurance, and out-of-pocket payments), and according to 148 health conditions, 38 age/sex groups, and 7 types of care from 2010 to 2019.Design, Setting, and ParticipantsObservational analysis using more than 40 billion insurance claims and nearly 1 billion facility records.ExposuresAmbulatory care, dental care, emergency department care, home health care, hospital inpatient care, nursing facility care, and purchase of prescribed retail pharmaceuticals.Main Outcomes and MeasuresHealth care spending and utilization (eg, number of visits, admissions, or prescriptions) estimates from 2010 through 2019.ResultsBetween 2010 and 2019, 76.6% of personal health care spending was captured by this study. More spending was on type 2 diabetes ($143.9 billion [95% CI, $140 billion-$147.2 billion]) than on any other health condition, followed by other musculoskeletal disorders, which includes joint pain and osteoporosis ($108.6 billion [95% CI, $106.4 billion-$110.3 billion]), oral disorders ($93 billion [95% CI, $92.7 billion-$93.3 billion]), and ischemic heart disease ($80.7 billion [95% CI, $79 billion-$82.4 billion]). Of total spending, 42.2% (95% CI, 42.2%-42.2%) was on ambulatory care, while 23.8% (95% CI, 23.8%-23.8%) was on hospital inpatient care and 13.7% (95% CI, 13.7%-13.7%) was on prescribed retail pharmaceuticals. At the county level, age-standardized spending per capita ranged from $3410 (95% CI, $3281-$3529) in Clark County, Idaho, to $13 332 (95% CI, $13 177-$13 489) in Nassau County, New York. Across counties, the greatest variation was in age-standardized out-of-pocket spending, followed by private insurance spending. Cross-county variation was driven more by variation in utilization rates than variation in price and intensity of care, although both types of variation were substantial for all payers but Medicare.Conclusions and RelevanceBroad variation in health care spending was observed across US counties. Understanding this variation by health condition, sex, age, type of care, and payer is valuable for identifying outliers, highlighting inequalities, and assessing health care gaps.
Confinement Improves Mass Transfer and Chemical Reactivity in Electrified Membranes for Micropollutant Degradation
Authors: Wu Yangyang , Chen Xinran , Chen Zefang , Crittenden John C. , Wang Zhiwei , Tong Xin 
Published: February 2025

AbstractMicropollutants (MPs) pose a significant threat to global water environments, necessitating advanced treatment technologies. Distributed electrochemical systems utilizing electrified membranes (EMs) show promise but face challenges due to unclear mass transfer and reaction mechanisms within membrane pores of varying sizes and surface chemistry. This review examines the interplay between spatial confinement, mass transfer, and chemical reactions in EMs, focusing on reactive species (RSs), the EM‐MPs system evolution, and mass transfer phenomena across pore sizes from microns to sub‐nanometer scales. Despite advances in RS research, a coherent mechanistic understanding of MP degradation under spatial confinement remains elusive, particularly under extreme confinement where mass transfer and reactions deviate from bulk behavior. Gaps in knowledge stem from complex mass transfer dynamics, chemical reaction thermodynamics and kinetics, and the need for detailed theoretical understanding to describe confinement effects. This review summarizes the generation mechanisms and detection methods for RSs, outlines progress in EM operational modes, and elucidates how spatial confinement impacts both mass transfer and chemical reactions. Future research shall focus on the precise identification and quantitative regulation of RSs, optimization of mass transfer processes in relation to RSs and MPs, and investigation of active sites and energetic barriers in confined environments.
Glucose Metabolism‐Targeted Poly(amino acid) Nanoformulation of Oxaliplatin(IV)‐Aspirin Prodrug for Enhanced Chemo‐Immunotherapy
Authors: Yang Jiazhen , Su Tianqi , Wang Qinqi , Shi Run , Ding Jianxun , Chen Xuesi 
Published: February 2025

AbstractInappropriate glucose metabolism in cancer cells is associated with immunosuppressive tumor microenvironments (TMEs). Although glycolysis inhibition enhances T cell‐mediated immune responses, the integrated platforms combining glycolysis inhibition with immunotherapy remain underdeveloped. To address this gap, a glucose metabolism‐targeted poly(amino acid) nanoformulation of oxaliplatin(IV)‐aspirin prodrug (NP/OXA‐ASP2) is developed to improve chemo‐immunotherapy by suppressing tumor glycolysis. This poly(amino acid) nanoparticle exhibits selective release, discharging 90.0% of OXA‐ASP2 under reductive conditions within 36 h. Furthermore, over 80% of the prodrug converts to OXA and ASP within 12 h, promoting mitochondrial damage and glycolysis inhibition, which amplifies immunogenic cell death induced by OXA. In addition, suppressing glycolytic flux reduces lactate leakage, mitigating the immunosuppressive TMEs. Together, these mechanisms contribute to stronger chemo‐immunotherapy efficacy. Compared to the OXA plus ASP formulation, NP/OXA‐ASP2 demonstrates superior performances, reducing lactate levels at the tumor site by 25.4%, increasing the proportion of cytotoxic T lymphocytes by 1.53 times, decreasing the proportion of regulatory T cells by 2.20 times, and improving 1.39‐fold of the tumor inhibition rate. These findings underscore that NP/OXA‐ASP2 is a promising platform for integrating tumor metabolic regulation with immunomodulation and holds significant potential for advancing clinical chemo‐immunotherapy.
In‐Sensor Polarization Convolution Based on Ferroelectric‐Reconfigurable Polarization‐Sensitive Photodiodes
Authors: Wang Xinyuan , Zhu Yuhan , Wang Feng , Sun Jie , Cai Yuchen , Li Shuhui , Wang Yanrong , Yan Tao , Zhan Xueying , Xu Kai , He Jun , Wang Zhenxing 
Published: February 2025

AbstractIn‐sensor computing can enhance the imaging system performance by putting part of the computations into the sensor. While substantial advancements have been made in latency, spectral range, and functionalities, the strategy for in‐sensor light polarization computing has remained unexplored. Here, it is shown that ferroelectric‐reconfigurable polarization‐sensitive photodiodes (FPPDs) based on BiFeO3 nanowire arrays can perform in‐sensor computations on polarization information. This innovation leverages the anisotropic photoresponse from the 1D structure of nanowires and the non‐volatile reconfigurability of ferroelectrics. The devices show programmable anisotropic ratios as high as 5219, surpassing most state‐of‐the‐art polarization‐sensitive photodetectors and commercial polarization image sensors. Employing tunable photoresponse as kernel, FPPDs can perform convolutions to directly extract feature maps containing polarization information, which raises the recognition accuracy on road‐scene objects under adverse weather up to 89.6%. The research highlights the potential of FPPDs as a highly efficient vision sensor and extends the boundaries of advanced intelligent imaging systems.