bluuebunny/crossref_metadata_2025_split huggingface dataset:
Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures
Authors: Casillas‐Espinosa Pablo M. , Garcia‐Olivares Jennie , Li Rui , Li Crystal , Yu Chungping , Formella Andrea E. , O'Brien Terence J. 
Published: August 2024

AbstractObjectiveWe evaluated huperzine A treatment in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model of genetic generalized epilepsy (GGE) with absence seizures.MethodsAdult male GAERS (N = 15) were implanted with EEG recording electrodes 10 days before receiving study drug. Each animal received the following six treatments as a single, intraperitoneal dose, 7 days apart (in random order): huperzine A (0.3, 1.0, or 3.0 mg/kg), two periods of vehicle (0.9% NaCl), or ethosuximide (100 mg/kg) as a positive control. Electroencephalograms (EEGs) were acquired for 24 h before and after each treatment and analyzed for seizure activity during the 90‐min period immediately post‐treatment, including 30‐min intervals at 30, 60, and 90 min. Additional analyses evaluated seizure activity over the 24‐h post‐treatment period using 60‐min intervals at 6, 12, and 24 h. The cumulative 24‐h periods before and after each administered treatment were also compared.ResultsTwo‐way ANOVA showed a treatment difference [F(91,182) = 3.592, p < 0.0001] on the number of seizures over the first 90‐min post‐treatment (primary outcome); Tukey's post hoc analyses showed that, compared to vehicle, huperzine A (3.0 mg/kg) significantly reduced seizures in the 30‐min (p = 0.02) and 60‐min (p = 0.001) intervals, and ethosuximide significantly reduced seizures at all measured time intervals except the 1‐h blocks at 12 and 24 h. Huperzine A 3.0 mg/kg and ethosuximide significantly reduced seizures during the cumulative 24‐h post‐treatment period relative to pretreatment baseline. While huperzine A 3.0 mg/kg did not differ significantly from ethosuximide at any time point, the study was not designed to evaluate non‐inferiority. The only adverse event after huperzine A or ethosuximide was mild, dose‐dependent sedation.SignificanceHuperzine A potently suppressed absence‐like seizures in GAERS, albeit with a shorter duration of action relative to ethosuximide, showing promise for clinical efficacy in GGE.Plain Language SummaryThis study looked at how huperzine A affects seizures in rats with similar abnormal brain activity as seen in humans with absence epilepsy. Rats received different treatments, placebo (i.e., saline solution), huperzine A, and ethosuximide. Ethosuximide is considered a gold standard treatment for absence epilepsy. We recorded brain activity to measure seizures before and after each treatment. We found that huperzine A (3.0 mg/kg) reduced seizures soon after treatment, like ethosuximide. Both treatments appeared safe, causing only mild sleepiness. The study shows that huperzine A could be a good new treatment for a type of absence epilepsy.
High frequency volatility of oil futures in China: Components, modeling, and prediction
Authors: Hong Yi , Xu Xiaofan , Yang Chen 
Published: August 2024

AbstractThis paper investigates the high‐frequency volatility modeling and prediction for crude oil futures in China, a new asset class emerging in recent years. Two volatility measures, the realized variance (
) and realized bi‐power variations (
) are constructed at various frequencies by virtue of 1‐minute crude oil futures prices. The distinctive components of these volatility estimators are further identified to exploit the information contents in the in‐sample explanatory power of the realized variance dynamics and the out‐of‐sample prediction of realized variance across different horizons, leading to four new HAR‐RV‐type models. First, the empirical results show that the continuous component of the weekly realized variance, representing investors' trading behavior in the medium‐term, is the dominant factor driving up volatility trends in China's crude oil futures market over a range of market conditions. Second, the monthly jump component in realized variance presents the significant in‐sample explanatory power, and yet marginally improves prediction performance in realized variance during the two out‐of‐sample periods. Finally, these results are robust toward various market/model setups, over day‐ and night‐trading hours, and across a range of prediction horizons and relative to prediction benchmarks.
Sequelae of carotid endarterectomy patch infection: An otolaryngologist perspective
Authors: Balouch Bailey , Gupta Aakanksha , Tjaden Bruce , Lombardi Joseph V. , Carpenter Jeffrey P. , Ahmad Nadir , Shapiro Yekaterina 
Published: August 2024

AbstractBackgroundPostoperative carotid endarterectomy (CEA) patch infection is a rare but well‐recognized complication of CEA. It is important for otolaryngologists to be aware of the presentation and challenges in its diagnosis.MethodsPatients who presented with a neck mass or hemorrhage and a known prior history of carotid endarterectomy with synthetic patch reconstruction were worked up with ultrasound, CT, or MRI imaging. In one case, fine needle aspiration biopsy was performed. Ultimately, all patients were taken to the operating room for neck exploration.ResultsOf the three patients presented in this case series, two presented with a chronic neck mass, two‐to‐three years after carotid endarterectomy. One patient presented acutely with hemorrhage from the carotid endarterectomy site. Carotid patch infection was diagnosed after neck exploration in all cases. Vascular surgery was consulted intra‐operatively to perform definitive vascular repair.ConclusionsInfected carotid patch should be suspected in patients with a history of prior CEA, as many of the presenting complaints may resemble or mimic pathology managed by otolaryngology. The onset of symptoms can be perioperative or very delayed. A multidisciplinary approach with vascular surgery and infectious disease is required for appropriate management of these patients.
Scene construction processes in the anterior hippocampus during temporal episodic memory retrieval
Authors: Hwang Maria Jieun , Lee Sang Ah 
Published: August 2024

AbstractAlthough the hippocampus has been implicated in both the temporal organization of memories and association of scene elements, some theoretical accounts posit that the role of the hippocampus in episodic memory is largely atemporal. In this study, we set out to explore this discrepancy by identifying hippocampal activity patterns related to scene construction while participants performed a temporal order memory task. Participants in the fMRI scanner were shown a sequence of photographs, each consisting of a central object and a contextual background scene. On each retrieval trial, participants were shown a pair of the original photographs (FULL), objects from the scenes without the background (OBJ), or background contexts without the main foreground object (BACK). In the temporal order judgment (TOJ) task, participants judged the temporal order of the pair of scenes; in the Viewing trials, two identical scenes were shown without any task. First, we found that the anterior hippocampus—particularly the CA1 and subiculum—showed similar patterns of activation between the BACK and OBJ conditions, suggesting that scene construction occurred spontaneously during both TOJ and Viewing. Furthermore, neural markers of scene construction in the anterior hippocampus did not apply to incorrect trials, showing that successful temporal memory retrieval was functionally linked to scene construction. In the cortex, time‐processing areas, such as the supplementary motor area and the precuneus, and scene‐processing areas, such as the parahippocampal cortex, were activated and functionally connected with the hippocampus. Together, these results support the view that the hippocampus is concurrently involved in scene construction and temporal organization of memory and propose a model of hippocampal episodic memory that takes both processes into account.
Predicting fidelity and treatment outcomes in savoring interventions among mothers of young children
Authors: Borelli Jessica L. , Perzolli Silvia , Kerr Margaret , Smiley Patricia A. 
Published: August 2024

AbstractSavoring impacts parents’ emotions and parent–child relationship quality. Using data from a randomized controlled trial (N = 164 mothers of 18–27‐month‐olds, 37 interveners) conducted with a community sample in the United States, this study examined predictors of fidelity and treatment outcomes across two savoring preventative interventions (relational savoring and personal savoring). Treatment outcome indicators were selected from a battery administered immediately post‐intervention (maternal closeness to child) and at a 3‐month follow‐up (maternal sensitivity, reflective functioning). We examined whether intervener education level (bachelor's degree/no bachelor's degree) predicted fidelity (Research Question 1), whether intervener education level predicted treatment outcomes (Research Question 2), and whether fidelity predicted treatment outcomes (Research Question 3). In many cases, intervener education background was not related to fidelity or treatment outcome; however, interveners without bachelor's degrees showed greater adherence to the protocols on some scales (higher positivity, higher secure base, higher calm matching) and sessions with these interveners were associated with greater increases in maternal sensitivity. Regardless of the intervener education level, redirecting attention to the positive and calmly matching participants’ tone were associated with higher maternal reflective functioning, and higher secure base scores were associated with greater closeness. Findings have implications for the training and implementation of prevention programs for parents.
The dimer effect: A refinement approach towards skin sensitization assessment in‐chemico using Amino acid Derivative Reactivity Assay
Authors: Paul Choudhury Ratnadeep , Singh Akanksha , Mathai Eldho , Sudhakar DGS , Tourneix Fleur , Alépée Nathalie , Gautier Francoise 
Published: August 2024

AbstractSkin sensitization is a key endpoint for safety assessment, especially for cosmetics and personal care products. The adverse outcome pathway for skin sensitization and the chemical and biological events driving the induction of human skin sensitization are now well understood. Several non‐animal test methods have been developed to predict sensitizer potential by measuring the impact of chemical sensitizers on these key events. In this work, we have focused on Key Event 1 (the molecular initiating step), which is based on formation of a covalent adduct between skin sensitizers and endogenous proteins and/or peptides in the skin. There exists three in‐chemico assays approved by the Organization for Economic Co‐operation and Development—(1) Direct Peptide Reactivity Assay (DPRA), (2) Amino Acid Derivative Reactivity Assay (ADRA), and (3) Kinetic Direct Peptide Reactivity Assay (kDPRA) to quantify peptide/amino acid derivative depletion after incubation with test chemicals. However, overestimated depletion of the cysteine‐based peptide/amino acid derivatives is known in such assays because of the dimerization of the thiol group. In this present work, we report the synthesis and structural confirmation of the dimer of N‐(2‐[1‐naphthyl]acetyl)‐L‐cysteine (NAC) from the ADRA assay to allow simultaneous determination of (a) peptide depletion by quantifying NAC monomer and (b) peptide dimerization by quantifying NAC dimer thereby eliminating the overestimation. We present a case study with three chemicals to demonstrate the importance of this approach. Thus, this simultaneous assay gives a more informed view of the peptide reactivity of chemicals to better identify skin sensitizers.
Protective effect of rutin on acrylamide induced ovarian inflammation, oxidative stress, DNA damage, and hormonal changes: Based on in silico and in vivo study
Authors: Gupta Divya , Shrivastava Sadhana , Kumar Subodh , Bhardwaj Gautam , Jain Chakresh , Kumar Suresh , Tonk Rajiv , Shukla Sangeeta 
Published: August 2024

AbstractAcrylamide (AA) is a carcinogenic compound that affects people due to its frequent use in laboratories and industry as well as the high‐temperature cooking of foods with high hydrocarbon content. AA is known to cause severe reproductive abnormalities. The main aim of this study is to evaluate the protective effect of rutin (RU), a phytoactive compound, against AA‐induced reproductive toxicity in female rats. Initially, rats were exposed to AA (40 mg/kg for 10 days). Therapy of RU was given after AA intoxication consecutively for 3 days. After 24 h of the last treatment, all the animals were sacrificed. The study evaluated reproductive hormones, oxidative stress markers, membrane‐bound enzymes, DNA damage, histological findings, and an in silico approach to determine the protective efficacy of RU. The results indicated that RU significantly protected against inflammation, oxidative stress, and DNA damage induced by AA, likely due to its antioxidant properties.
Impact of sensory neuropeptide deficiency on behavioral patterns and gait in a murine surgical osteoarthritis model
Authors: Rapp Anna E. , Wolter Angelique , Muschter Dominique , Grässel Susanne , Lang Annemarie 
Published: August 2024

AbstractSubstance P (SP) and a calcitonin‐related gene alpha (αCGRP−/−) are implicated in musculoskeletal pain perception and were shown to have different effects on the pathogenesis of osteoarthritis (OA). However, it has not been investigated, whether deficiency for SP or αCGRP impacts pain‐related behavior and well‐being as well as gait during development of experimental OA. We induced OA in the right knee of wild‐type (WT) mice and mice either deficient for SP (tachykinin 1, Tac‐1) or αCGRP (male, n = 8 per genotype) by destabilizing the medial meniscus (DMM). We monitored body weight and food and water intake as indicators of wellbeing, determined nest building and composite pain score, and performed CatWalk gait analysis over 12 weeks. Cartilage degeneration was determined by OARSI scoring. The 12‐week post‐DMM, cartilage degradation in the medial compartment was significantly reduced in Tac1−/− mice compared to the WT and to αCGRP−/− mice, coinciding with highest unloading of the operated limb in Tac1−/−. Behavioral and gait analysis revealed only minor differences between the genotypes. Paw print area was most prominently reduced in Tac1−/− over the observation period; at 12 weeks, we found a significant reduction in normalized print area in Tac1−/− compared to presurgery and to the WT at the same time‐point. Calculated weight bearing was significantly reduced only in Tac1−/−. Overall, we observed minor impact of DMM on gait and behavior in the present study. The reduced cartilage damage in the absence of SP might be in part due to reduced loading, however, the mechanism is not clear yet.
A Consensus Statement on the Administration of Systemic Bevacizumab in Patients with Recurrent Respiratory Papillomatosis
Authors: Best Simon R. , Bock Jonathan M. , Fowler Nicole B. , Raabe Eric H. , Klein Adam M. , Laetsch Theodore W. , McClellan Kim , Rinkel Rico N.P.M. , Saba Nabil F. , Sidell Douglas R. , Tansey James B. , Tunkel David E. , Young Geoffrey D. , Zur Karen B. 
Published: August 2024

ObjectiveTo provide detailed guidance on the administration of systemic bevacizumab in patients with recurrent respiratory papillomatosis (RRP) based on a detailed review of the scientific literature and a consensus of experts with real‐world clinical experience.MethodsA bevacizumab consensus working group (N = 10) was composed of adult and pediatric otolaryngologists, adult and pediatric oncologists, and a representative from the RRP Foundation (RRPF), all with experience administering systemic bevacizumab in patients with RRP. After extensive review of the medical literature, a modified Delphi method‐based survey series was utilized to establish consensus on the following key areas: clinical and patient characteristics ideal for treatment candidacy, patient perspective in treatment decisions, treatment access, initial dosing, monitoring, guidelines for tapering and discontinuation, and reintensifying therapy.ResultsSeventy‐nine statements were identified across nine critical domains, and 45 reached consensus [clinical benefits of bevacizumab (3), patient and disease characteristics for treatment consideration (7), contraindications for treatment (3), shared decision‐making (incorporating the patient perspective) (5), treatment access (3), initial dosing and administration (8), monitoring (7), tapering and discontinuation (6), and reintensification (3)].ConclusionThis consensus statement provides the necessary guidance for clinicians to initiate systemic administration of bevacizumab and represents a potential paradigm shift toward nonsurgical treatment options for patients with RRP.Level of Evidence5 Laryngoscope, 134:5041–5046, 2024
CaLu2Mg2Si3O12:Ce3+, Cr3+, Nd3+ Phosphor‐In‐Glass Film for Laser‐Driven Ultra‐Broadband Near‐Infrared Lighting with Watt‐Level Output
Authors: Lin Yi , Lin Hang , Wang Pengfei , Xu Ju , Cheng Yao , Wang Yuansheng 
Published: August 2024

AbstractLaser diode (LD)‐pumped phosphor‐converted near‐infrared (NIR) lighting source predicts a “brighter” future for active imaging and non‐destructive detection, with improved imaging resolution and detection accuracy to expand more application scenarios. To meet a variety of requirements for LD‐pumped phosphor color converters, herein, a novel CaLu2Mg2Si3O12:Ce3+, Cr3+, Nd3+ (CLMS:Ce3+, Cr3+, Nd3+) phosphor‐in‐glass film (PiGF) sintered on sapphire substrate (SP) composite is fabricated. By introducing a rapid infrared firing technique, the good luminescence properties of phosphor powders are maintained in the PiGF due to the trivial thermally‐aggressive effect of glass components on phosphor particles. The multiple energy transfers (ETs) among Ce3+, Cr3+, and Nd3+ enhance the NIR luminescence of Cr3+ and Nd3+, and simultaneously extend the spectral range to cover the NIR‐I and NIR‐II regions. The luminescent behaviors of samples are carefully examined under different laser excitation modes to gain more insights into laser‐matter interaction. A watt‐level output is achieved by applying appropriate thermal and optical management. A comparative study is performed on the luminescence saturation mechanism of CLMS:Ce3+, Cr3+, Nd3+ PiGF showing different contributions of thermal quenching and intensity quenching among these three ions. Finally, the application presentations confirm the great potential in the fields of long‐distance night vision and high‐resolution biological imaging.
A High‐Quality Mixed Matrix Membrane with Nanosheets Assembled and Uniformly Dispersed Fillers for Ethanol Recovery
Authors: Pang Siyu , Ma Liang , Yang Yongfu , Chen Huidong , Lu Lu , Yang Shihui , Baeyens Jan , Si Zhihao , Qin Peiyong 
Published: August 2024

AbstractA high‐quality filler within mixed matrix membranes, coupled with uniform dispersity, endows a high‐efficiency transfer pathway for the significant improvement on separation performance. In this work, a zeolite‐typed MCM‐22 filler is reported that is doped into polydimethylsiloxane (PDMS) matrix by ultrafast photo‐curing technique. The unique structure of nanosheets assembly layer by layer endows the continuous transfer channels towards penetrate molecules because of the inter‐connective nanosheets within PDMS matrix. Furthermore, an ultrafast freezing effect produced by fast photo‐curing is used to overcome the key issue, namely filler aggregation, and further eliminates defects. When pervaporative separating a 5 wt% ethanol aqueous solution, the resulting MCM‐22/PDMS membrane exhibits an excellent membrane flux of 1486 g m−2 h−1 with an ethanol separation factor of 10.2. Considering a biobased route for ethanol production, the gas stripping and vapor permeation through this membrane also shows a great enrichment performance, and the concentrated ethanol is up to 65.6 wt%. Overall, this MCM‐22/PDMS membrane shows a high separation ability for ethanol benefited from a unique structure deign of fillers and ultrafast curing speed of PDMS, and has a great potential for bioethanol separation from cellulosic ethanol fermentation.
On the Mechanism of Nucleation and Monomer Transport in Inverse Emulsion Polymerization
Authors: Schork F. Joseph 
Published: August 2024

AbstractA rationale for droplet nucleation during inverse emulsion polymerization (IEP) (reported by previous investigators) is proposed. Based on the idea that smaller monomer droplets are nucleated into polymer particles, while larger droplets serve as reservoirs for monomer (as in a micellar nucleation mechanism) the question of possible monomer‐transport limitation during polymerization is explored.
Effect of core densities on quasi‐static and low‐velocity impact behaviors of AFRP‐aluminum foam hybrid sandwich beams
Authors: Wang Zhen , Hong Bin , Xian Guijun , Xin Meiyin , Huang Shengde , Shen Haijuan 
Published: August 2024

AbstractThe hybrid sandwich structures possessing composite faces and an aluminum foam (ALF) core exhibit lightweight and superior impact resistance. However, limited studies pay attention to the mechanical behavior of hybrid sandwich beams with various ALF densities. The present article has focused on the influence of foam densities on the quasi‐static and low‐velocity impact (LVI) behaviors of hybrid sandwich beams with aramid‐fiber‐reinforced polymer (AFRP) faces and ALF core. The failure mode, loading response, and energy absorption of sandwich beams have been obtained experimentally and the failure map with a wide range of dimensional configurations has been established theoretically. Increasing core density significantly enhances the load‐carrying capacity of the sandwich beam, and the enhanced effect becomes more obvious for a thicker core. The medium‐density ALFs provide the maximum specific energy absorption, while the high‐density ALFs offer the highest energy absorption for hybrid sandwich beams. The applicability of core densities in hybrid sandwich structures is provided.Highlights
Normal strain distribution under quasi‐static loading is analyzed using DIC.
AFRP face microbuckling provides higher impact resistance than core failure.
The applicability of core density in hybrid sandwich structures is given.