bluuebunny/crossref_metadata_2025_split huggingface dataset:
Celecoxib and Diclofenac Plus Omeprazole are Similarly Effective in the Treatment of Arthritis in Patients at High GI Risk in the CONDOR Trial§
Authors: Kellner Herbert L. , Li Chunming , Essex Margaret N. 
Published: November 2013

Objective:
Compare effectiveness of celecoxib versus diclofenac plus omeprazole in improving arthritis signs and symptoms in patients at high gastrointestinal (GI) risk who were enrolled in the CONDOR (Celecoxib vs Omeprazole and Diclofenac in Patients With Osteoarthritis and Rheumatoid Arthritis) trial.

Methods:
CONDOR was a 6-month, prospective, double-blind, triple-dummy, parallel-group, randomized, multicenter trial comparing celecoxib 200 mg twice daily versus diclofenac slow release (SR) 75 mg twice daily plus omeprazole 20 mg daily. Patients were Helicobacter pylori negative, had osteoarthritis (OA) or rheumatoid arthritis (RA), were aged ≥60 years, were with or without a history of gastroduodenal ulceration, or were ≥18 years with previous gastroduodenal ulceration. Patients’ Global Assessment of Arthritis was determined at each study visit.

Results:
A total of 4484 patients were randomized to treatment (2238 celecoxib, 2246 diclofenac SR) and included in the intention-to-treat analyses. Least squares mean (LSM) (standard error [SE]) for Patients’ Global Assessment of Arthritis was 3.219 (0.017) and 3.221 (0.017) at baseline for celecoxib and diclofenac SR (p=0.90). Improvement in both groups was similar in months 2, 4, and 6; at month 1 the LSM (SE) was 2.647 (0.017) and 2.586 (0.017) for celecoxib and diclofenac (p=0.0025). LSM difference (SE) from baseline to final visit demonstrated an improvement of 0.75 (0.02) in celecoxib-treated patients and 0.77 (0.02) in diclofenac SR-treated patients (p=0.42).

Conclusions:
Celecoxib and diclofenac plus omeprazole were shown to have similar efficacy in patients with OA and/or RA at increased GI risk who were enrolled in the CONDOR trial.

Trial Registry:
Trial was registered under ClinicalTrials.gov identifier NCT00141102.
miR-29a and miR-30c negatively regulate DNMT 3a in cardiac ischemic tissues: implications for cardiac remodelling
Authors: Gambacciani Carolina , Kusmic Claudia , Chiavacci Elena , Meghini Francesco , Rizzo Milena , Mariani Laura , Pitto Letizia 
Published: November 2013

AbstractRecent evidences indicate that epigenetic changes play an important role in the transcriptional reprogramming of gene expression that characterizes cardiac hypertrophy and failure and may dictate response to therapy. Several data demonstrate that microRNAs (miRNAs) play critical roles both in normal cardiac function and under pathological conditions. Here we assessed, in in vivo rat models of myocardial infarction (MI) and ischemia-reperfusion (IR), the relationship between two miRNAs (miR-29a and miR-30c) and de novo methyltransferase (DNMT3a) which, altering the chromatin accessibility for transcription factors, deeply impacts gene expression. We showed that the levels of members of miR-29 and miR- 30 families were down regulated in ischemic tissues whilst the protein levels of DNMT3a were increased, such a relation was not present in healthy tissues. Furthermore, by an in vitro assay, we demonstrated that both miRNAs are able to down regulate DNMT3a by directly interacting with DNMT3a 3’UTR and that miR-29a or miR-30c overexpression in the cardiac HL1 cell line causes decrease of DNMT3a enzyme both at the mRNA and protein levels. Our data, besides confirming the down regulation of the miR-29a and miR-30c in infarcted tissues, envisage a cross-talk between microRNAs and chromatin modifying enzymes suggesting a new mechanism that might generate the alterations of DNA methylation often observed in myocardial pathophysiology.
Stacked configuration of rectangular and hexagonal patches with shorting pin for circularly polarized wideband performance
Authors: Rawat Sanyog , Sharma K. 
Published: November 2013

Abstract
The radiation characteristics of a stacked microstrip antenna geometry proficient of providing circular polarization along with wide impedance bandwidth is simulated by using IE3D software and later on this antenna was fabricated on FR-4 substrate with an air gap and testing is done in free space. The feed location, location of applied shorting pin and width of air gap introduced between driver element and parasitically coupled element were optimized to obtain best results. The measured impedance bandwidth better than 31.72% and axial ratio bandwidth close to 1.68% were achieved with the proposed geometry. The simulated and measured results obtained are in good match with each other.
Synthesis of carnallite crystal from KCl – MgCl2 solutions and its characterization
Authors: Podder J. , Gao S. , Evitts R. W. , Besant R. W. , Matthews D. 
Published: November 2013

Abstract
Carnallite crystals have been synthesized from KCl – MgCl2 brine solutions at room temperature (23 °C) using a solvent evaporation technique. The effects of the concentration of potassium chloride (KCl) and magnesium chloride (MgCl2) on growth, structural and mechanical properties of the carnallite crystal is investigated and discussed. Transparent and pseudo-hexagonal shaped carnallite crystals with dimensions of 4 × 5 × 2 mm to 16 × 13 × 3 mm are shown. The carnallite crystals were characterized using powder X-ray diffraction and the lattice parameters were found to be a = 9.575 Å, b = 16.155 Å and c = 22.526 Å, space group: Pnna, Z: 12, α = β = γ = 90° with a unit cell volume, V = 3 485.04 Å3. The lattice parameters are found to be in good agreement with standard values and the structure of the crystal is orthorhombic. Vickers micro-hardness testing was carried out to determine the hardness and work hardening coefficient of the carnallite crystals.
Mediating Cultural Transfer
Authors: Win Thong 
Published: November 2013

The Scent of Papaya (Mùi đu đủxanh), 1993, Président Films, written and directed
by Tran Anh Hung, starring Tran Nu Yên-Khê, Man San Lu, Thi Loc
Truong.Cyclo (Xich Lo), 1995, Les Productions Lazennic, Lumiere, La Sept Cinema, La
SFP Cinema (Cinepix Film Properties 2006), written and directed by Tran Anh
Hung, starring Le Van Loc, Tony Leung Chiu Wai, Tran Nu Yen Khe.I Come With the Rain, 2009, TF1 International, written and directed by Tran
Anh Hung, starring Josh Hartnett, Tran Nu Yen Khe, Byung-hun Lee, Takuya
Kimura, Shawn Yue.
The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis
Authors: Sonabend Adam M. , Zacharia Brad E. , Goldstein Hannah , Bruce Samuel S. , Hershman Dawn , Neugut Alfred I. , Bruce Jeffrey N. 
Published: November 2013

Object
Central nervous system (CNS) hemangiopericytomas are relatively uncommon and unique among CNS tumors as they can originate from or develop metastases outside of the CNS. Significant difference of opinion exists in the management of these lesions, as current treatment paradigms are based on limited clinical experience and single-institution series. Given these limitations and the absence of prospective clinical trials within the literature, nationwide registries have the potential to provide unique insight into the efficacy of various therapies.

Methods
The authors queried the Surveillance Epidemiology and End Results (SEER) database to investigate the clinical behavior and prognostic factors for hemangiopericytomas originating within the CNS during the years 2000–2009. The SEER survival data were adjusted for demographic factors including age, sex, and race. Univariate and multivariate analyses were performed to identify characteristics associated with overall survival.

Results
The authors identified 227 patients with a diagnosis of CNS hemangiopericytoma. The median length of follow-up was 34 months (interquartile range 11–63 months). Median survival was not reached, but the 5-year survival rate was 83%. Univariate analysis showed that age and radiation therapy were significantly associated with survival. Moreover, young age and supratentorial location were significantly associated with survival on multivariate analysis. Most importantly, multivariate analysis using the Cox proportional hazards model showed a statistically significant survival benefit for patients treated with gross-total resection (GTR) in combination with adjuvant radiation treatment (HR 0.31 [95% CI 0.01–0.95], p = 0.04), an effect not appreciated with GTR alone.

Conclusions
The authors describe the epidemiology of CNS hemangiopericytomas in a large, national cancer database, evaluating the effectiveness of various treatment paradigms used in clinical practice. In this study, an overall survival benefit was found when GTR was accomplished and combined with radiation therapy. This finding has not been appreciated in previous series of patients with CNS hemangiopericytoma and warrants future investigations into the role of upfront adjuvant radiation therapy.
Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage
Authors: Kantor Ellen , Bayır Hülya , Ren Dianxu , Provencio J. Javier , Watkins Laura , Crago Elizabeth , Horowitz Michael B. , Ferrell Robert E. , Conley Yvette P. , Alexander Sheila A. 
Published: November 2013

Object
Haptoglobin allele heterogeneity has been implicated in differential reactive oxidant inhibition and inflammation. Haptoglobin α2-α2 has a lower affinity for binding hemoglobin, and when bound to hemoglobin, is cleared less easily by the body. The authors hypothesized that haptoglobin α2-α2 genotype should be less protective for downstream injury after aneurysmal subarachnoid hemorrhage (aSAH) and should portend a worse outcome.

Methods
Patients with Fisher Grade 2 or higher aSAH were enrolled in the study. Genotyping for haptoglobin genotype was performed from blood and/or CSF. Demographic information, medical condition variables, and hospital course were abstracted from the medical record upon enrollment into the study. Outcome data (modified Rankin Scale score, Glasgow Outcome Scale score, and mortality) were collected at 3 months posthemorrhage.

Results
The authors enrolled 193 patients who ranged in age from 18 to 75 years. Only Caucasians were used in this analysis to minimize bias from variable haptoglobin allele frequencies in populations of different ancestral backgrounds. The sample had more women than men (overall mean age 54.45 years). Haptoglobin α2 homozygotes were older than the other individuals in the study sample (57.27 vs 53.2 years, respectively; p = 0.02) and were more likely to have Fisher Grade 3 SAH (p = 0.02). Haptoglobin α2-α2 genotype, along with Fisher grade and Hunt and Hess grade, was associated with a worse 3-month outcome compared to those with the haptoglobin α1-α1 genotype according to modified Rankin Scale score after controlling for covariates (OR 4.138, p = 0.0463).

Conclusions
Patients with aSAH who carry the haptoglobin α2-α2 genotype had a worse outcome. Interestingly, the presence of a single α-2 allele was associated with worse outcome, suggesting that the haptoglobin α-2 protein may play a role in the pathology of brain injury following aSAH, although the mechanism for this finding requires further research. The haptoglobin genotype may provide additional information on individual risk of secondary injury and recovery to guide care focused on improving outcomes.
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma
Authors: Davies Jason M. , Robinson Aaron E. , Cowdrey Cynthia , Mummaneni Praveen V. , Ducker Gregory S. , Shokat Kevan M. , Bollen Andrew , Hann Byron , Phillips Joanna J. 
Published: November 2013

Object
The management of patients with locally recurrent or metastatic chordoma is a challenge. Preclinical disease models would greatly accelerate the development of novel therapeutic options for chordoma. The authors sought to establish and characterize a primary xenograft model for chordoma that faithfully recapitulates the molecular features of human chordoma.

Methods
Chordoma tissue from a recurrent clival tumor was obtained at the time of surgery and implanted subcutaneously into NOD-SCID interleukin-2 receptor gamma (IL-2Rγ) null (NSG) mouse hosts. Successful xenografts were established and passaged in the NSG mice. The recurrent chordoma and the derived human chordoma xenograft were compared by histology, immunohistochemistry, and phospho-specific immunohistochemistry. Based on these results, mice harboring subcutaneous chordoma xenografts were treated with the mTOR inhibitor MLN0128, and tumors were subjected to phosphoproteome profiling using Luminex technology and immunohistochemistry.

Results
SF8894 is a novel chordoma xenograft established from a recurrent clival chordoma that faithfully recapitulates the histopathological, immunohistological, and phosphoproteomic features of the human tumor. The PI3K/Akt/mTOR pathway was activated, as evidenced by diffuse immunopositivity for phospho-epitopes, in the recurrent chordoma and in the established xenograft. Treatment of mice harboring chordoma xenografts with MLN0128 resulted in decreased activity of the PI3K/Akt/mTOR signaling pathway as indicated by decreased phospho-mTOR levels (p = 0.019, n = 3 tumors per group).

Conclusions
The authors report the establishment of SF8894, a recurrent clival chordoma xenograft that mimics many of the features of the original tumor and that should be a useful preclinical model for recurrent chordoma.
Levetiracetam versus (fos)phenytoin for seizure prophylaxis in pediatric patients with intracranial hemorrhage
Authors: Bansal Seema , Blalock Dan , Kebede Tewodros , Dean Nathan P. , Carpenter Jessica L. 
Published: November 2013

Object
Seizure prophylaxis is used in a variety of conditions, including supratentorial intracranial hemorrhage (ICH). In adults, studies have demonstrated phenytoin as the drug of choice for seizure prophylaxis; in children, levetiracetam is often provided due to its favorable side effect profile and pharmacokinetics. This study evaluated the difference in efficacy between these treatment options.

Methods
This retrospective review included 126 patients between 1 month and 17 years of age with acute supratentorial ICH; all received seizure prophylaxis. Demographic data and outcome assessments were compared.

Results
Seizure prophylaxis was provided with (fos)phenytoin in 40 children, levetiracetam in 61 children, and both drugs in 25 patients. Baseline characteristics of the treatment groups were similar, except that more patients treated with (fos)phenytoin had seizures on presentation. Patients treated solely with (fos)phenytoin had a higher probability of early seizures (within 7 days of ICH) compared with those treated only with LVT, controlling for relevant variables including seizures on presentation (OR 24.6, p = 0.002). Patients treated with (fos)phenytoin were more likely to need additional antiepileptic drugs for seizure control (p = 0.005). There was no significant difference in the incidence of late seizures (> 7 days after ICH) (p = 0.265). Adverse events necessitating a change in therapy were uncommon.

Conclusions
Levetiracetam is a reasonable alternative to (fos)phenytoin for prophylaxis of early posthemorrhagic seizures. Levetiracetam and (fos)phenytoin are well tolerated in children. Prospective studies are needed to determine superiority, optimal dosing, and impact on long-term outcomes.
A rapid Drug Susceptibility Test (DST) for detection of Multi-Drug Resistant (MDR) Mycobacterium tuberculosis from direct sputum sample in Category II failure Tuberculosis patients.
Authors: Rahman Fahmida , Miah Md. Ruhul Amin , Kamal Md. Mustafa , Sattar Humayan , Saleh Ahmed Abu , Ahmed Sharmeen , Tarafder Shirin , Anwar Shaheda 
Published: November 2013

This study was designed for early detection of drug resistance in Category II failure tuberculosis (TB) patients and to introduce a simple method to detect multi-drug resistant Mycobacterium tuberculosis (M.TB) from direct sputum sample. Total one hundred Ziehl-Neelsen (Z-N) staining positive Category II failure TB patients were enrolled in this study. Culture and drug susceptibility was done by slide and conventional method, among which 90 samples were positive by slide culture and 87 samples were positive by conventional culture. Susceptibility test by slide method showed 85 (94.44%) resistance to one or more anti -TB drugs. Resistance to Isoniazide (INH), Rifampicin (RMP), Ofloxacin (OFX) and Kanamycin (KA) was 94.44%, 84.44%, 31.11% and 4.44% respectively. By this method 80% isolates were detected as Multi-drug resistant (MDR) M.TB and 4.44% isolates were detected as Extended drug resistant (XDR) M.TB. Susceptibility results by slide DST demonstrated good concordance with conventional DST methods. Statistical analysis showed that, Sensitivity of slide DST method was 98.8%. Susceptibility results were available much faster by slide DST method (12.5±0.5 days) compared to that by conventional DST (60.4±5.9 days). Rate of contamination was also much lower by slide DST method than conventional culture (0.18% Vs 3.25%). The present study reflected that the slide DST method could be applied as rapid diagnostic tool to detect drug resistance among Category II failure TB cases, which is essential for applying appropriate therapy.DOI: http://dx.doi.org/10.3329/bjmm.v5i2.16910 Bangladesh J Med Microbiol 2011; 05 (02): 6-10
Evaluation of two new rapid diagnostic tests (RDTs) for the diagnosis of malaria
Authors: Jahan Fahmida , Elahi Rubayet , Mohiuddin Md. Khaja , Khan Md. Gulam Musawwir , Alam Mohammad Shafiul , Noor Rashed 
Published: November 2013

Rapid diagnostic tests (RDTs) address the need for accurate diagnosis of malaria, particularly in resource limited settings. In this study, two malaria RDTs were compared with gold standard microscopy: On Site Pf/Pv test detecting Plasmodium falciparum-specific histidine rich protein-2 (Pf HR P2) and P. vivax-specific parasitic lactate dehydrogenase (pLDH) antigens; and SD Bioline anti-Pf/Pv test detecting anti-HR P2 and anti-pL DH antibodies for the diagnosis of P. falciparum and P. vivax infections, respectively. For OnSite test, the overall sensitivity was found 96.2% , specificity 98.2% , positive predictive value (PPV ) 98.2% , negative predictive value (NPV ) 96.4% and agreement with microscopy was found to be 0.94. On the other hand SD Bioline test, the overall sensitivity was 75.4%, specificity 83.7%, PPV 84.3% , NPV 74.5% and agreement with microscopy was 0.59. These data revealed that the R DT based on antigen detection (Onsite test) was more reliable than that based on the antibody detection (SD Bioline test).DOI: http://dx.doi.org/10.3329/bjmm.v5i2.16931 Bangladesh J Med Microbiol 2011; 05 (02): 11-15
Antibiogram of Urinary Escherichia coli isolated in Sir Salimullah Medical College Mitford Hospital, Dhaka.
Authors: Jhora Sanya Tahmina , Paul Shikha , Begum Bilkis Ara , Chowdhury Abul Quashem 
Published: November 2013

Urinary tract infections (UTIs) are one of the most common infectious diseases & an important cause of morbidity in general population. More than 90% of all uncomplicated UTI s are caused by Esch. coli infection. The study was carried out in Department of Microbiology of Sir Salimullah Medical College & Mitford Hospital (SSMC& MH) Dhaka from October 2002 to September 2003. A total of 749 urine samples were studied of which 414 (55.27) showed significant growth. Among the 414 isolates, E sch. coli was the most predominant (82.61%) organism. Esch. coli was highly sensitive to Imipenem (95.02%) followed by Ceftriaxone (86.84%), Cefuroxime (67.54%), Gentamicin (66.08%), and Ceftazidime (55.84%) respectively. Low sensitivity patterns were shown against Nitrofurantoin (44.73%) & Ciprofloxacin (40.64%). The sensitivity to other antibiotics varied from 23.39% to as low as 2.63%. The aim of the present study was to observe the antibiotic sensitivity pattern of isolated Esch. coli from urine samples of patients admitted in inpatient department or visited the out patient department of Sir Salimullah Medical College & Mitford Hospital (SSMC& MH) Dhaka.DOI: http://dx.doi.org/10.3329/bjmm.v5i2.16934 Bangladesh J Med Microbiol 2011; 05 (02): 23-26
Plasmodium malariae in Chittagong, Bangladesh
Authors: Haque Muhammad Ehsanul , Husain Muhammad Anwar , Akter Nasima , Mazed Muhammad Abdul , Alam Khan Mashrequl , Sultan Muhammad Tipu , Dewanjee Arup Kanti , Ahmed Muhammad Shaqil , Rahman Muhammad Arifur , Hossain Muhammad Zakir 
Published: November 2013

We detected a case of Plasmodium malariae in Chittagong, Bangladesh. The person was an adult male, presented clinically as severe malaria. B lood slide examination by microscopy and pan malarial immunochromatographic test (ICT) revealed the case as Plasmodium malariae infection. The patient presented as severe malaria case for which he was hospitalized and recovered after seven days of quinine treatment.DOI: http://dx.doi.org/10.3329/bjmm.v5i2.16936 Bangladesh J Med Microbiol 2011; 05 (02): 30-31
Aurélia ou le Rêve et la Vie , de Gérard de Nerval
Authors: Spoljar Philippe 
Published: November 2013

Aurélia ou le Rêve et la Vie , de G. de Nerval, est un récit poétique clinique relatant l’évolution tragique d’un délire de filiation qui problématise un deuil maternel insondable. L’auteur tente de métaphoriser l’espace hallucinatoire de son « rêve » en le transformant narrativement et poétiquement en un Destin. Il reconstruit fantasmatiquement son propre fondement qui est un monde originaire où l’image d’une Mère absolue est rendue équivalente au Tout, ce qui marquera aussi le temps de sa rencontre avec sa mort.
L'incident frontalier du printemps 2013 : un essai d'interprétation des relations sino-indiennes
Authors: Saint-Mézard Isabelle 
Published: November 2013

La transition du pouvoir qui s’est opérée à la tête de la République populaire de Chine entre l’automne 2012 et le printemps 2013 a retenu l’attention des autorités indiennes surtout par les gestes amicaux dont elles ont fait l’objet. Ces gestes d’amitié ont laissé espérer des avancées sur les dossiers de sécurité qui perturbent les liens par ailleurs denses et diversifiés entre les deux pays. Mais, au moment où la nouvelle équipe dirigeante chinoise tentait de déployer une politique d’amitié vers l’Inde, un sérieux incident dans les zones frontalières est venu rappeler que le rapport sino-indien restait marqué par une profonde asymétrie. Cet incident, le plus grave depuis la fin des années 1980, confirme surtout que les deux voisins s’enferment dans un préoccupant dilemme de sécurité. Si le principe de statu quo sur les zones frontalières demeure le point de référence des autorités de part et d’autre, il va s’affaiblissant en raison de mouvements militaires de petite ampleur, mais de portée symbolique importante, sur les hauteurs himalayennes.
Oxygen‐Involved Oxidative Deacetylation of α‐Substituted β‐Acetyl Amides – Synthesis of α‐Keto Amides
Authors: Li Dianjun , Yu Wei 
Published: November 2013

Abstractα‐Substituted β‐acetyl amides could undergo CC bond cleavage to form α‐keto amides when treated with copper(II) chloride (CuCl2) and boron trifluoride diethyl etherate (BF3⋅OEt2) under an oxygen atmosphere. The yield can be increased by the addition of tert‐butyl hydroperoxide which alone can also effect the reaction. The reaction provides a new protocol for the synthesis of α‐keto amides.magnified image
Suzuki–Miyaura Cross‐Coupling under Solvent‐Free Conditions
Authors: Asachenko Andrey F. , Sorochkina Kristina R. , Dzhevakov Pavel B. , Topchiy Maxim A. , Nechaev Mikhail S. 
Published: November 2013

AbstractA solvent‐free reaction protocol for Suzuki–Miyaura cross‐couplings was developed. (Hetero)aryl bromides and chlorides are coupled with pinacol arylboronates in high yields. The reaction is catalyzed by conventional bis(triphenylphosphine)palladium(II) chloride [(PPh3)2PdCl2] and/or palladium(II) acetate/SPhos [Pd(OAc)2/SPhos] under air.magnified image