bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Hydrogen Bond Networks in Nicinquinium Salts
Authors: Borowiak Teresa , Dutkiewicz Grzegorz , Thiel Jacek 
Published: February 2015

Abstract
Crystals of nicinquinium chloride and bromide incorporate water molecules due to the im­ balance of hydrogen bond donors and acceptors. The resulting intermolecular hydrogen bond system indicates a better proton accepting ability of chloride ions than bromide ions. The chlo­ ride anions accept four hydrogen bonds in an almost tetrahedral arrangement whereas only two are formed with the bromide anions. As a consequence in the crystal structure of the chloride a three dimensional network of hydrogen bonds is formed, while in that of the bromide only chains of hydrogen bonded species exist. Both cations retain the absolute configuration of all asymmetric carbon atoms as compared with the absolute configuration of the parent cinchonine.
Crystal Structure and Magnetic Properties of a Binuclear Copper(II) Complex Bridged by an Alkoxo-oxygen Atom and an Acetate Ion
Authors: Zeyrek C. T. , Elmali A. , Svoboda I. , Fuess H. 
Published: February 2015

[Cu4(L)2(O2CMe)2] H2O (L = 1,3-bis(5-bromo-2-hydroxybenzylidene)propan-2-ol) was synthesized and its crystal structure determined. (C38H34N4O10Br4Cu4)·H2O, monoclinic, space group P21/c, a = 21.072(5), b = 9.673(2), c = 21.934(4) Å, β = 109.73(2)°, V = 4208(2) Å3, Z = 4. The crystal structure consists of two independent binuclear copper(II) complexes and the non-coordinating water molecule in the asymetric unit. The Cu(II) ions are in a square-planar geometry and coordinated by donor atoms of the ligand (NO3).
The average Cu···Cu distance and average Cu-O-Cu angle are 3.491(2) Å and 132.0(1)°, respectively. Temperature-dependent magnetic susceptibility measurements of the complex show an intramolecular anti ferromagnetic coupling in the dimeric Cu(II) core. The fitting parameters are -2J = 174.4 cm-1, g = 1.98.
Synthesis and Spectroscopic Investigations of New Linear Heterobimetallic Clusters [Me4N]3[(TOS3 )2Ag] (T = Mo, W). Crystal Structure of [Me4N]3[(MoOS3 )2Ag]
Authors: Shamsur Rahman A. B. M. , Boiler H. , Klepp K. O. 
Published: February 2015

Abstract
Red-brown crystals of a new bis(thiomolybdate) complex [Me4N]3[(MoOS3)2Ag] were formed at room temperature through the reaction of a solution of [Me4N]2[MoOS3] in MeCN with solid AgCN. They are monoclinic, space group P21/c with unit cell parameters a = 16.662(9), b = 9.464(3), c = 17.890(8) A, /3 = 101.87(2)°, Z = 4. The crystal structure was determined from single crystal diffractometer data (MoKα-radiation) and refined to R = 0.044 (3614 reflections, 236 variable parameters). The structure is characterized by trinuclear complex anions, [(MoOS3)2Ag]3-. According to Weissenberg investigations the homologous tungsten compound is isostructural.
The infrared spectrum of the molybdenum complex (KBr powder) shows absorption bands at 884 (vs) and 871 (w) cm-1 (terminal v(Mo-0)), 483 (vs) cm-1 (terminal v(Mo-S)), 451 (vs), and 435 (w) cm-1 (bridging v(Mo-S)). The tungsten complex showed bands at 901 (vs) cm-1 (terminal v(W-O)), 478 (vs) cm-1 (terminal v(W-S)), and 435 (vs) cm-1 (bridging v(W-S)). The anionic mass spectra shows molecular ion peaks at m/z 524 and 700 for [(MoOS3)2Ag]- and [(WOS3)2Ag]-, respectively, as well as peaks for other fragments.
Komplexe gemischter Siliciumhalogenide mit 3,4-Lutidin / Complexes of Mixed Silicon Halides with 3,4-Lutidine
Authors: Hensen Karl , Mayr-Stein Ralf , Spangenberg Björn , Bolte Michael , Rühl Stephan 
Published: February 2015

Abstract
The first single crystal X-ray investigations of 3,4-lutidine complexes with mixed silicon tetrahalides were carried out
Vierzähnige Benzamidin-Liganden in ein-und mehrkemigen Kupfer(II)-Komplexen / Quadridentate Benzamidine Ligands in Mono-and Oligonuclear Copper(II) Complexes
Authors: Leßmann F. , Beyer L. , Hallmeier K.-H. , Richter R. , Sieler J. , Strauch P. , Voigt A. 
Published: February 2015

Abstract
Bridged N-thiocarbamoyl substituted bis-benzamidines (C2H5)2N-C(S)-N=C(Ph)-NH-R-NH-C(Ph)=N-C(S)-N(C2H5)2 with different moieties R (H2L1 : R = diphenylmethane-2,2'-diyl, H2 L2: R = diphenylmethane-3,3'-diyl, and H2L3: R = diphenylmethane-4,4'-diyl) were synthe­sized by the reaction of N-(thiocarbamoyl)benzimidoyl chlorides with diamines. These quadri­ dentate ligands form neutral mononuclear (CuL1), dinuclear (Cu2L3
2) and trinuclear (Cu3L2
3) copper(II) chelates in dependence of the different bridging unit in the ligands. The compounds were characterized by NMR, IR, EPR and XPS spectroscopy and FAB mass spectrometry. The molecular structures of the ligand H2L3 and the complex CuL1 have been determined by X-ray methods.
Syntheses and Structures of Thorium(IV) Complexes with Bis(diphenylphosphino)ethane Dioxide, Ph2P(O)CH2CH2P(O)Ph2, and Bis(diphenylphosphoryl)amide, [Ph2P(O)NP(O)Ph2]
Authors: Bonfada Élida , Schulz-Lang Ernesto , Zan Renato André , Abram Ulrich 
Published: February 2015

Abstract
The cationic thorium(IV) complexes [Th{Ph2P(O)CH2CH2P(O)Ph2}2(NO3)3]NO3 and [Th{Ph2P(O)NP(O)Ph2}3(dmso)2]NO3 have been synthesized by reactions of Th(NO3)4 · 5H2O with bis(diphenylphosphino)ethane dioxide, Ph2P(O)CH2CH2P(O)Ph2 (L1), or ammonium bis(diphenylphosphoryl)amide, (NH4)[Ph2P(O)NP(O)Ph2] (NH4L2), and subsequent recrystallization from dimethyl sulfoxide. The products have been studied spectroscopically and by X-ray crystallography.
The thorium atom is ten-co-ordinate in the [Th(L1)2(NO3)3]+ cation with a coordination sphere which does not match one of the idealized polyhedra for ten-coordination. Th-O bonds have been found in the range between 2.342(3) (phosphine oxide) and 2.599(4) A (nitrate). An eight-coordinate thorium atom is found in the [Th(L2)3(dmso)2]+ cation. The almost ideal square-antiprismatic environment of the metal is occupied by oxygen atoms with Th-0 bond lengths between 2.363(6) and 2.392(11) Å
Polysulfonylamine, CXXV [1]. Neue Komplexe von Disulfonylaminen mit Kronenethern - im voraus entworfen oder zufällig entdeckt / Polysulfonylamines, CXXV [1]. New Complexes of Disulfonylam ines with Crown Ethers - Preconceived or Discovered by Serendipity
Authors: Henschel Dagmar , Wijaya Karna , Moers Oliver , Blaschette Armand , Jones Peter G. 
Published: February 2015

Abstract
In a study aim ed at the „deconstruction“ of the supramolecular aggregate 3(18C6) · 2HN( SO2Me)2 (1,18C6 = 18-crown-6), which is known to display a ladder structure with two isotactic [18C6 - Me SO2N(H)SO2Me···)∞ polymers forming the uprights and symmetrically N - H···O bonded 18C6 rings providing the rungs, the following crystalline complexes were isolated and (except for 2b) characterized by low-temperature X-ray diffraction: 18C6-ClN (SO2Me)2 (2a, triclinic, space group P1̅, Z = 2), 18C6-PhN (SO2Me)2 (2b), 18C6 -MeN(SO2Me)2 (3, monoclinic, P21/c, Z = 8), Bz18C6-HN(SO2Me)2 (4, Bz18C6 = benzo-18-crown-6, monoclinic, P21/n, Z = 4), 18C6-2 MeN (SO2Me)2 (5, triclinic, P1̅, Z = 1), 18C6-Me2SO- HN( SO2Me) (SO2Ph) (13, triclinic, P1̅, Z = 2), and 18C6-H2OMe2SO·2HN(SO2Me)2 (14, triclinic, P1̅, Z = 2). Each of the one-dimensional polymers 2a (syndiotactic), 3 (disyndiotactic) and 4 (isotactic) mimics a single upright of 1; in contrast to 1 and 2a, where the intra-catemer connectivity solely relies on S - Me ··· crow n and crown ··· O = S hydrogen bonds, this bonding system is reinforced in 3 by N -Me ··· crown and in 4 by N - H ··· crown hydrogen bonds. Complex 5 is monomeric and matches a fragment formally extruded from the catemer 3; moreover, 3 and 5 represent a rare case of two structurally characterized 18C6 complexes containing the same uncharged guest species in distinct molecular ratios. The surprising structure of the quaternary adduct 14 exhibits an [18C6 ··· MeSO2N(H)SO2Me ··· ]∞ chain, which can be regarded both as an isolated, though unmodified upright from the ladder 1 and, being syndiotactic, as a stereochemical analogue of 2a; the potentially rung-forming *NH functions in the chain are blocked by hydrogenbonded side chains of the type * N - H ··· water ··· sulfoxide ··· H - N (SO2Me)2. The ternary complex 13 consists of chains [18C6 ··· Me2SO ··· H - N (SO2Ph)SO2Me···]∞ and is not closely related to the other structures
Uber die Isolierung von Sitosterin-(6'-O-acyl)-β-D-glucopyranosiden aus Flacourtia indica und über unerwartete Gelbildungen durch das Triacetat / On the Isolation of Sitosterin-(6'-O-acyl)-β-D-glucopyranosides from Flacourtia indica and on Unexpected Formation of Gels by the Triacetate
Authors: Dehmlow Eckehard Volker , Guntenhoner Matthias , Ree Teunis van 
Published: February 2015

Abstract
A mixture of the title compound-(6′) stearate, margarate, palmitate, linolate, and linole- nate (2a-e) was isolated from shredded dried leaves and twigs of Flacourtia indica. The margarate was observed for the first time. 0.5% solutions of the triacetate mixture (1a-e) in methanol or ethanol give “solid" gels stable for months. From these the unchanged triacetates 1a-e can be recovered indicating that this low-molecular material is responsible for the formation of the gel.
Crystal Structure of 4-(1-Hydroxypropyl)- isochroman-1,3-dione
Authors: Abou Akoun , Goulizan Bi Severin D. , Kaboré Leopold , Djandé Abdoulaye , Saba Adama , Kakou-Yao Rita 
Published: February 2015

The title compound (C12H10O4) crystallizes in the triclinic space group P1̄ with a = 7.367(3), b = 8.1188(3), c = 9.549(5) Å, α = 74.034(1)°, β = 84.374(2)°, γ = 64.581(3)°, Z = 2, and dcalc = 1.462 g cm−3. It exhibits a strong intramolecular O-H···
O hydrogen bond and exists as the exocyclic enolic tautomer as it has been observed in solution. The structure is stabilized by C-H···π, C-O···π and π-π stacking interactions between benzene and pyran rings.
Synthese und Kristallstrukturen von N-[ω-(Dimethylammonio)alkyl]- N´,N´,N´´,N´´-tetramethylguanidinium-chlorid-tetraphenylboraten / Synthesis and Crystal Structures of N-[ω-(Dimethylammonio)alkyl]-N´,N´,N´´,N´´- tetramethylguanidinium Chloride Tetraphenylborates
Authors: Tiritiris Ioannis , Lissner Falk , Schleid Thomas , Kantlehner Willi 
Published: February 2015

Dicationic N,N´,N´,N´´,N´´-pentasubstituted guanidinium dichlorides 4a, b are obtained from the chloroformamidinium salt 2 and diamines 3a, b. N-[2-(Dimethylammonio)ethyl]-N´,N´,N´´,N´´-tetramethylguanidinium chloride tetraphenylborate (5a) and N-[3-(dimethylammonio)propyl]-N´,N´,N´´,N´´-tetramethylguanidinium chloride tetraphenylborate (5b) were synthesized from 4a, b by anion metathesis with one equivalent of sodium tetraphenylborate. The thermal properties of the salts 5a, b were studied by means of DSC methods, and their crystal structures were determined by single-crystal X-ray diffraction analysis. For 5a a solid-solid phase transition is observed at −156 ◦C to a low-temperature structure. The room-temperature modification (α-5a) crystallizes in the centrosymmetric orthorhombic space group Pbca (a = 13.1844(4), b = 13.8007(4), c = 34.7537(11) A° ).
The guanidinium ions are interconnected via chloride ions through bridging N-H· · ·Cl hydrogen bonds, providing isolated units. The tetraphenylborate ions show some dynamic disordering in the crystal structure. The low-temperature modification (β -5a) also crystallizes orthorhombically, but in the non-centrosymmetric space group Pna21 (a = 13.1099(4), b = 69.1810(11), c = 13.5847(5) A° ) and consists of four crystallographically independent cations and anions in the unit cell. Compared with the room-temperature structure, a similar N-H· · ·Cl hydrogen bond pattern is observed in the β -phase, but the tetraphenylborate ions are now completely ordered. 5b crystallizes in the monoclinic space group P21/c (a = 10.8010(3), b = 14.1502(5), c = 20.9867(9) A° , β = 94.322(1)◦). In the crystal structure the guanidinium ions are linked via chloride ions through N-H· · ·Cl hydrogen bonds, but in contrast to 5a two infinite strands are formed along the a axis with the tetraphenylborate ions interspersed between them for charge compensation.
Mannich Bases as Synthetic Intermediates: Convenient Synthesis of Functionalized 1,2,4-Triazepines, 1,4-Diazepines and 1,5-Diazocines
Authors: Afsah Elsayed M. , Keshk Eman M. , Abdel-Rahman Abdel-Rahman H. , Jomah Najla F. 
Published: February 2015

Transamination between the ketonic Mannich bases 1a, b and primary arylamines gave a series of ketonic sec-Mannich bases 2a - h. A variety of tetrahydro-1,2,4-triazepines 3a - f have been synthesized by treating the arylhydrazones of 2 with formaldehyde. A similar reaction with the benzenesulfonylhydrazone of 2b afforded 4. The 3-styryl-2H-1,2,4-triazepine 5 was obtained from the phenylhydrazone of 2a and cinnamaldehyde. Treatment of arylhydrazones of the 4-methoxystyryl keto base 7 with formaldehyde and cinnamaldehyde afforded the 3,4,5,6-tetrahydro-2H-1,2,4-triazepines 8a, b. Mannich reaction with 4-(p-hydroxyphenyl)-tetrahydro-1,2,4-triazepine 3d afforded the Mannich bases 9, 10 and 11.
The reaction of 1b with o-phenylenediamine leads to the 1,5-benzodiazepine 13. The new tetrahydro- 1,4-diazepine and tetrahydro-1,5-diazocine Mannich bases 15 and 17 were obtained from 1b and ethylenediamine or 1,3-diaminopropane, respectively. The bi(piperidine) derivative 19 was obtained from 1a and 1,3-diaminopropane.
Theoretical Description of the Coding Potential of Diamino-5-formamidopyrimidines
Authors: Cysewski Piotr , Oliński Ryszard 
Published: February 2015

Abstract
The results of geometry optimisation of possible Watson-Crick-like pairs o f 2,6-diamino-4-oxy-5-formamidopyrimidine (fapy-adenine) or 4,6-diamino-5-formamidopyrimidine (fapy-guanine) were presented. In the absence of the external field the fapy-adenine is able to form pairs with all four canonical nucleic acid bases. However, pairs with guanine, cytosine and thymine the most stable are. Thus, the potential miscoding abilities may be observed. In contrast, in the presence of the external field the mispairing abilities of fapy-adenine become insignificant since the most stable dimers are formed with thymine.
The pairing properties of fapy-guanine are complex and depend on its tatomeric form. In the absence of an external field the 4-enol-6-keto-diamino tautomer of fapyG is able to form stable dimers with thymine and cytosine, while the 4,6-diketo-diamino tautomer forms the most stable pairs with cytosine and guanine. The presence of the water solvent does not significantly alter the pairing abilities of fapy-guanine. However, pairs with thymine are at least as stable as the Watson-Crick GC pair. Thus, in polar conditions the mispairing potential of fapyG will be extended and may be enriched by potential GC → AT transition.
Bioactive Terpenes from the Soft Coral Heteroxenia sp. from Mindoro, Philippines
Authors: Edrada Ru Angelie , Wray Victor , Witte Ludger , Ofwegen Leen van , Proksch Peter 
Published: February 2015

Abstract
A marine soft coral species of the genus Heteroxenia collected from Mindoro Island, Philippines yielded two cadinene sesquiterpenes, (+)-α-m uurolene (1) and a novel derivative (+)- 6 -hydroxy-α-muurolene (2 ), as well as the biologically active polyhydroxysterol, sarcoaldosterol A (3). The structure of the novel compound was unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long range 13C -1H correlations) and mass spectrometric (EIMS) data. All compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. The isolated terpenes were also active in the brine shrimp lethality test.
Antinociceptive Properties of Morusin, a Prenylflavonoid Isolated from Morus nigra Root Bark
Authors: Souza Márcia Maria de , Bittar Magali , Cechinel-Filho Valdir , Yunes Rosendo Augusto , Messana Irene , Monache Franco Delle , Ferrari Franco 
Published: February 2015

Abstract
The antinociceptive effects of morusin (1), the main prenylflavonoid present in the Morns nigra root barks have been investigated in classical models of pain in mice. The results showed that 1 exhibits a prom ising antinociceptive or analgesic profile by the intraperitoneal route, being more potent than some standard drugs used as reference. The mechanism by which the morusin exerts antinociceptive activity still remains undetermined, but our results strongly suggest that it involves the participation of the opioid system.
Antinematodal Activity of Some Tropical Rainforest Plants against the Pinewood Nematode, Bursaphelenchus xylophilus
Authors: Alen Yohannes , Nakajima Shuhei , Nitoda Teruhiko , Baba Naomichi , Kanzaki Hiroshi , Kawazu Kazuyoshi 
Published: February 2015

Abstract
Sixty five methanolic extracts of Sumatran rainforest plants representing 63 species of 21 families were assayed in vivo for antinematodal activity against Bursaphelenchus xylophilus using our cotton ball-fungal mat method. Extracts of 27 plants species from 14 families exhibited antinematodal activity, while 37 species were inactive. Among them, three extracts of Bischofia javanica, Knema hookeriana and Areca catechu exhibited very strong activity at minimum effective dose (MED ) of 0.7 mg/cotton ball (mg/bl.). Eight extracts from Allamanda cathartica, Ervatamia corymbosa, Hoya diversifolia, Bischofia javanica, Derris malacensis, Melastoma melabathricum, Ophiorriza konsteleary and Brucea sumatrana also showed strong activity (MED, 5 mg/bl.).
Induction of DNA-Protein Cross-Links by Platinum Compounds
Authors: Woźniak Katarzyna , Walter Zofia 
Published: February 2015

Abstract
The differences between cis- and trans-diamminedichloroplatinum II (DDP) in forming DNA-protein cross-links in isolated human lymphocytes were investigated. Both cis- and trans-DDP can induce DNA-protein cross-links. We show that cis-DDP forms complexes between DNA and proteins faster than trans-DDP. This results from an increase in the quantity of DNA and platinum together with an increase in drug concentration. Under the same conditions trans-DDP causes a decrease in DNA-forming complexes with proteins. After a 12 h incubation of lymphocytes we observe a similar level of DNA in DNA-protein crosslinks induced by DDP isomers, but more platinum appears in complexes induced by trans- DDP. The results obtained demonstrate that the antitumor drug - cis-DDP and the clinically ineffective trans-DDP induce links between DNA and proteins in a different manner. We suggest that the therapeutic activity of ds-DDP can in part arise from rapidly forming DNA-protein complexes which can destroy the most important cellular processes, such as replication and transcription.
Volatile Compounds of Cashew Apple (Anacardium occidentale L.)
Authors: Bicalho Beatriz , Rezende Claudia M. 
Published: February 2015

Abstract
The volatile compounds of a largely consumed Brazilian cashew apple variety (Anacardium occidentale L. var. nanum , Anacardiaceae) were recovered by headspace extraction or simultaneous distillation-extraction. Several compounds including esters (29), terpenes (16), hydrocarbons (9), carboxylic acids (7), aldehydes (7), alcohols (3), ketones (2), lactones (2) and norisoprenoids ( 1 ) were characterized and quantified by gas chromatography-mass spectrometry analyses.
Early Elicitor-Induced Events in Chickpea Cells: Functional Links between Oxidative Burst, Sequential Occurrence of Extracellular Alkalinisation and Acidification, K+/H+ Exchange and Defence-Related Gene Activation
Authors: Otte Oliver , Pachten Andreas , Hein Frauke , Barz Wolfgang 
Published: February 2015

Abstract
Elicitation of cultured chickpea (Cicer arietinum L.) cells stimulates a signal transduction pathway leading to several rapid responses: (1) oxidative burst, (2) extracellular alkalinisation, (3) extracellular acidification, (4) transient K+ efflux, and (5) activation of defence related genes all within 2 hours. Induced genes are encoding acidic and basic chitinases, a thaumatin-like protein and isoflavone reductase. All these elicitor-induced responses are in­ hibited by the Ser/Thr protein kinase inhibitor staurosporine and the anion channel blocker anthracene-9-carboxylic acid but stimulated by the Ser/Thr protein phosphatase 2A inhibitor cantharidin. The oxidative burst leads to a transient extracellular H2O2 accumulation which seems to be preceded by O2
- production, indicating dismutation of O2
-to H2O2. The oxidative burst is accompanied by transient alkalinisation of the culture medium which is followed by long-lasting extracellular acidification. An 80 percent inhibition of the alkalinisation after complete inhibition of the H2O2 burst with diphenylene iodonium indicates that the elicitor induced increase of extracellular pH is mainly based on a proton consumption for O2
-dismutation. A simultaneous deactivation of the plasma membrane H+-ATPase during oxidative burst and extracellular alkalinisation is also suggested. The elicitor-stimulated extracellular acidification is inhibited by the plasma membrane H+-ATPase inhibitor N, N'-dicyclohex-ylcarbodiimide assuming a reactivation of the H+-ATPase 25 min after elicitation. Extracellular acidification seems not to be necessary for elicitor-induced activation of defence related genes. Opposite modulation of K+ and proton fluxes after elicitation and/or treatment with the H+-ATPase effectors fusicoccin or N, N'-dicyclohexylcarbodiimide indicate that the elicitor induced transient K+ efflux is regulated by a K+/H+ exchange reaction.
Insect Growth Regulatory Activity of Some Extracts and Compounds from Parthenium argentatum on Fall Armyworm Spodoptera frugiperda
Authors: Céspedes Carlos L. , Martinez-Vázquez Mariano , Calderón Jose S. , Salazar Juan R. , Aranda Eduardo 
Published: February 2015

Abstract
Argentatins, Insect Growth Regulators, Acetylcholinesterase The methanolic extract from aerial parts of Parthenium argentatum, afforded argentatin A and B. These compounds were evaluated for their effect on the fall armyworm (Spodoptera frugiperda). Toosendanin, a commercial insecticide derived from Melia azedarach was used as positive control. When tested for activity, using neonate larvae into the no-choice artificial diet bioassays, argentatin A, argentatin B and methanol extract caused significant growth inhibitory activity with GC50 of 17.8, 36.1 and 6.4 ppm at 7 days, respectively, and increased the development time of surviving larvae in a concentration-dependent manner with RGI values of 0.40, 0.60 and 0.26, at 25.0, 25.0 and 5.0 ppm. respectively. In addition, it was possible to observe in most of the treated groups a significant delay in the time of pupation, adult emergence and deformities. Acute toxicity against adults of S. frugiperda was also found, MeOH extract had the most potent activity with LD50 value of 3.10 ppm. In addition, MeOH extract and argentatin A caused acetylcholinesterase inhibition of 93.7% and 90.0%, at 5.0 and 50.0 ppm, respectively; whereas argentatin B had only slight inhibitory activity. Therefore, the MeOH extract was identified as insecticidal extract from P. argentatum with activity at concentrations above 15.0 ppm.
Mariannaeapyrone -a New Inhibitor of Thromboxane A2 Induced Platelet Aggregation
Authors: Fabian Kerstin , Anke Timm , Sterner Olov 
Published: February 2015

Abstract
Mariannaeapyrone ((E)-2-(1,3,5,7-tetramethyl-5-nonenyl)-3,5-dimethyl-6-hydroxy-4H-pyran-4-one) is a new fungal metabolite isolated from fermentations of the common mycophilic deuteromycete Mariannaea elegans. The chemical structure of the 4-pyrone was determined by spectroscopic techniques. Mariannaeapyrone is a selective inhibitor of the thromboxane A2 induced aggregation of human platelets, whereas only weak cytotoxic and antimicrobial effects could be observed.