bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute dreigingen, vage geruchten
Authors: van Gestel Barbra , de Poot Christianne 
Published: December 2014

Immediate threats, vague rumors: Investigation of terrorist offenses and the action space of police and judicial officials
Since 2007 the police and the public prosecution service in the Netherlands can apply special investigative powers in case of ‘indications’ of a terrorist offense. To investigate signs of terrorism, a suspicion is no longer needed. The underlying assumption behind this extension is that the ‘old’ legislation offers insufficient opportunities to investigate signs of terrorism in an early phase. In this article we examine this assumption about the action space of investigating officers. For the period 2007-2011, we examined how investigating officers responded to signs of terrorism in practice, what investigative powers they used, and how they – as street level bureaucrats – handled their discretionary authority. The research shows that police and judiciary officials are very well able to investigate signs of terrorism with the already existing powers, and that they have made little use of the new ‘indications’ criterion
De diagnostische waarde van bewijs
Authors: Rassin Eric 
Published: December 2014

The diagnostic value of evidence
Traditionally, the Dutch penal judge needs to determine whether the suspect has committed the crime for which he is being prosecuted. This is generally done by accumulating incriminating evidence. Recently, it has been argued that this accumulation fosters the risk of a miscarriage of justice. Alternatively, the judge may want to rely on a Bayesians analysis of the evidence. Particularly, diagnostic values for each piece of evidence must be established. Therefore, it must be investigated how well the evidence fits in the primary and in alternative scenarios. This approach is discussed in this contribution.
Event‐triggered obstacle avoidance tracking control of quadrotor unmanned aerial vehicle
Authors: Wang Xia , Wu Peng , Tang Yujun , Fu Lei , Meng Aiwen 
Published: August 2024

SummaryThis article addresses the safe tracking control problem of quadrotor unmanned aerial vehicles (QUAV) considering uncertain aerodynamics and unknown external disturbances. First, a robust adaptive backstepping controller is designed, where the bias of the control variable, that is, the tracking error of the attitude subsystem, is considered in the design process of the position subsystem. Meanwhile, the safe obstacle avoidance objective is realized by the quadratic programming (QP) method that combines the tracking controller with the exponential control barrier function (ECBF). Furthermore, an event‐triggered mechanism is used for the QP process to conserve computing resources. Simulation validates the feasibility and superiority of the proposed control scheme in presence of multi‐obstacle.
Functionalized 2D/3D Heterojunction with Reversible Iodine‐Alkenes Reaction in Perovskite Solar Cells
Authors: Yang Hui , Cui Zhengbo , Li Wen , Guo Xuemin , Lu Chunyan , Yuan Haobo , Hu Yuyang , Zhang Wenxiao , Li Xiaodong , Fang Junfeng 
Published: August 2024

AbstractLong‐term operational stability remains a big challenge for perovskite solar cells (PSCs), especially under ISOS protocol with high temperature. One key reason lies in the iodine loss issue during PSCs aging. Motived by the reversible iodine‐alkenes reaction, 3‐butenylamine (BEA) based 2D perovskite (BEA)2[PbBr4] is used to construct a functionalized 2D/3D heterojunction in PSCs. (BEA)2[PbBr4] can chemically adsorb photo‐generated iodine species during perovskite degradation through a typical reaction between neutral iodine and terminal alkenes, thus inhibiting iodine loss or diffusion in PSCs. Besides, owing to the reversible reaction nature, these adsorbed iodine species can be partially released slowly under heat conditions, further reacting with and eliminating potential metallic Pb0 defects. The resulting PSCs exhibit a high efficiency of 24.5% with good operational stability even without encapsulation, retaining ≈94% of initial efficiency after MPP tracking for 2000 h at 65 °C with ISOS‐L‐2 protocol.
Functional Natural Aluminum Silicate Hydroxide Based Separators Enable Stable Zinc Metal Anodes with Long Cycle Life
Authors: Liu Shuang , Fang Luan , Li Jinhui , Hu Xinyu , Chang Limin , Jian Juan , Xu Tianhao , Wang Hairui , Wang Xuxu , Nie Ping 
Published: August 2024

AbstractBenefiting from high safety, low cost, and competitive energy density, aqueous zinc ion batteries (AZIBs) have emerged as very promising technology for grid energy storage. However, the lifetime of AZIBs is severely affected by uncontrolled zinc dendritic growth and undesirable side reaction. To address the problem, natural aluminum silicate hydroxide covered glass fibers separator (AlSi‐GF) is prepared herein using a simple spraying method. Aluminum silicate hydroxide is a complex oxide, where a large number of adsorption sites can adsorb Zn2+ and guide its deposition process. In particular, the Maxwell–Wagner polarization of aluminum silicate hydroxide under an applied electric field contributes to homogenizing the electric field distribution around the interface, thereby modulating zinc deposition and reducing the nucleation overpotential. Impressively, AlSi‐GF separator enables high‐performance zinc‐metal batteries. The symmetric battery with AlSi‐GF separator has a stable voltage polarization and an ultra‐long cycle life of 2280 h at a current density of 1 mA cm−2, and the Zn//V2O5 full cell based on AlSi‐GF separator can exhibit a high specific capacity of 123 mAh g−1 after 1500 cycles at 1 A g−1. This study provides new insights into the design of reliable and cost‐effective separators for metal anodes in energy storage devices.
Engineering Lipid‐Based Pop‐up Conductive Interfaces with PEDOT:PSS and Light‐Responsive Azopolymer Films
Authors: Terenzi Luca , Gao Ziyu , Ravandeh Mehdi , Fedele Chiara , Klausen Lasse Hyldgaard , Bovio Claudia Latte , Priimagi Arri , Santoro Francesca 
Published: August 2024

AbstractSignificant challenges have emerged in the development of biomimetic electronic interfaces capable of dynamic interaction with living organisms and biological systems, including neurons, muscles, and sensory organs. Yet, there remains a need for interfaces that can function on demand, facilitating communication and biorecognition with living cells in bioelectronic systems. In this study, the design and engineering of a responsive and conductive material with cell‐instructive properties, allowing for the modification of its topography through light irradiation, resulting in the formation of “pop‐up structures”, is presented. A deformable substrate, composed of a bilayer comprising a light‐responsive, azobenzene‐containing polymer, pDR1m, and a conductive polymer, PEDOT:PSS, is fabricated and characterized. Moreover, the successful formation of supported lipid bilayers (SLBs) and the maintenance of integrity while deforming the pDR1m/PEDOT:PSS films represent promising advancements for future applications in responsive bioelectronics and neuroelectronic interfaces.
Half‐metallization Atom‐Fingerprints Achieved at Ultrafast Oxygen‐Evaporated Pyrochlores for Acidic Water Oxidation
Authors: Xu Zuozheng , Meng Ming , Zhou Gang , Liang Chenglong , An Xingtao , Jiang Yuxuan , Zhang Yongcai , Zhou Yong , Liu Lizhe 
Published: August 2024

AbstractThe stability and catalytic activity of acidic oxygen evolution reaction (OER) are strongly determined by the coordination states and spatial symmetry among metal sites at catalysts. Herein, an ultrafast oxygen evaporation technology to rapidly soften the intrinsic covalent bonds using ultrahigh electrical pulses is suggested, in which prospective charged excited states at this extreme avalanche condition can generate a strong electron–phonon coupling to rapidly evaporate some coordinated oxygen (O) atoms, finally leading to a controllable half‐metallization feature. Simultaneously, the relative metal (M) site arrays can be orderly locked to delineate some intriguing atom‐fingerprints at pyrochlore catalysts, where the coexistence of metallic bonds (M─M) and covalent bonds (M─O) at this symmetry‐breaking configuration can partially restrain crystal field effect to generate a particular high‐spin occupied state. This half‐metallization catalyst can effectively optimize the spin‐related reaction kinetics in acidic OER, giving rise to 10.3 times (at 188 mV overpotential) reactive activity than pristine pyrochlores. This work provides a new understanding of half‐metallization atom‐fingerprints at catalyst surfaces to accelerate acidic water oxidation.
Nickel‐Catalyzed Cross‐Coupling of Aryl Alkyl Selenides with Aryl Bromides: Cross‐Coupling Between Two Electrophiles
Authors: Kumar Sumit , Sapra Shivani , Singh Brajendra K. 
Published: August 2024

AbstractA nickel‐catalyzed cross‐coupling reaction has been developed using two distinct electrophiles: an aryl alkyl selenide and an aryl bromide. The organoselenium compound, due to the lower bond dissociation energy of the C−Se bond, acts as a pseudohalide. This one‐pot reaction proceeds by cleaving the C−Se bond, producing the desired biaryls in moderate to good yields. The use of commercially available aryl bromides eliminates the handling of pre‐formed organomagnesium reagents, enhancing the practicality and applicability of this approach.
Porous Silicon Microparticles Enable Sustained Release of GLP‐1R Agonist Peptides for the Treatment of Type 2 Diabetes
Authors: Zangabad Parham Sahandi , Vasani Roshan B , Tong Ziqiu , Anderson Dovile , Rudd David , Hick Caroline A. , Wootten Denise , Sexton Patrick M. , Yan Li , Esser Lars , Voelcker Nicolas H. 
Published: August 2024

AbstractGLP‐1R agonist peptides play a prominent role in the treatment of type 2 diabetes. However, these peptides often suffer from short plasma half‐life, rapid clearance, and low in vivo chemical stability; requiring higher dosages and frequent administration. Although some peptides can be modified to improve these properties, such modification may lead to lower potency and immunogenicity. Here, a subcutaneously (SC) administrable porous silicon microparticle (pSiMP) platform for the sustained release of GLP‐1R agonist peptides is reported. The proof‐of‐concept involves using FDA‐approved exenatide, a potent GLP‐1R agonist, showcasing the platform's efficacy for therapeutic GLP‐1R peptides. pSiMPs with tailored particle size, pore dimensions, and surface chemistry unlock the potential for optimized loading and release of this peptide. The positively charged pSiMPs, with a pore diameter of 8 ± 3 nm, show an impressive loading capacity of 338 ± 42 µg mg−1 (exenatide/pSiMP). This optimized pSiMP formulation demonstrates extended and sustained exenatide release over 2 weeks in a bespoke in vitro SC tissue model. Notably, the pSiMP platform shields the peptide payload from proteolysis. In a mouse model, the SC‐injected formulation exhibits sustained in vivo release of exenatide in plasma for up to 2 weeks.
Foreign aid, exchange rate regime, and agricultural trade
Authors: Kim Kyunghun , Lim Sunghun 
Published: August 2024

AbstractThe least developed agrarian countries often face an ironic situation where well‐intentioned foreign aid adversely influences their economies. This study explores the unintended consequences of official development assistance (ODA) from donor countries on agricultural exports from recipient countries by appreciating their domestic exchange rates. Motivated by the fact that ODA accounts for a larger share of their total GDP, we first examine whether ODA inflows increase the real effective exchange rate of the recipient country. Leveraging data from 47 countries over the period 2001–2018, we find that ODA inflows lead to real exchange rate appreciation, particularly in recipient countries with floating exchange rate regimes that are more susceptible to exchange rate fluctuations. Moreover, our results reveal that ODA inflows decrease agricultural exports in low‐income agrarian economies adopting floating exchange rate regimes. By taking a unique perspective of ODA as an inflow of foreign capital, this study highlights the importance of understanding the exchange rate regime and agricultural trade of the agrarian economy when providing international aid.
Foreign labor, peer‐networking and agricultural efficiency in the Italian dairy sector
Authors: Antonioli Federico , Severini Simone , Vigani Mauro 
Published: August 2024

AbstractWhile the presence of immigrants in the agricultural sector is widely acknowledged, the empirical evidence on its economic consequences is lacking, especially from a microeconomic perspective. Using the Farm Accountancy Data Network panel data for Italian dairy farms in the period 2008–2018, the present study investigates the relationship between foreign workforce and farm– technical efficiency, considering the workers' country of origin. We rely on different peer‐network theories, and using a stochastic frontier analysis accounting for the endogeneity of immigrant labor force. Results point to the general positive contribution of immigrants on Italian farms' efficiency, while unpaid family labor exerts a null‐to‐negative influence. We detected an important effect of peer‐working, namely complementary task specialization and conformity behavior, with diverse groups of workers associated to different efficiency levels. The evidence of the positive correlation between immigrants and the efficiency of the agricultural sector has significant implications for the design of immigration policies and the access to domestic agri‐food markets, especially for those sectors in higher labor demand, as well as speeding up the process of economic and social integration of the labor force. [EconLit citations: Q12, Q18, J61, C23, C26].
Prevalence rates for ectodermal dysplasia syndromes
Authors: Butcher Clayton , Abbott Becky M. , Grange Dorothy , Fete Mary , Meyer Beau , Spinka Christine , Fete Timothy 
Published: August 2024

AbstractBackgroundEctodermal dysplasias (EDs) are a heterogeneous group of genetic conditions affecting the development and/or homeostasis of two or more ectodermal derivatives, including hair, teeth, nails, and certain glands. There are currently 49 recognized EDs with molecularly confirmed etiology. The EDs are very rare disorders, individually and in aggregate. Very little is published regarding the prevalence of these rare disorders. As a result of the genomics revolution, rare diseases have emerged as a global health priority. The various disabilities arising from rare disorders, as well as diagnostic and treatment uncertainty, have been demonstrated to have detrimental effects on the health, psychosocial, and economic aspects of families affected by rare disorders. Contemporary research methodologies and databases can address what have been historic challenges encountered when conducting research on rare diseases.ObjectiveIn this study, we aim to ascertain period prevalence rates for several of the more common ectodermal dysplasia syndromes, by querying a large multicenter database of electronic health records, Oracle Real‐World Data.MethodsFor each of the included ectodermal dysplasia syndromes a clinical definition was developed by a committee of international experts with interests in EDs. The clinical definitions were based upon a combination of clinical features and designated by ICD‐9 and ICD‐10 codes. The January 2023 version of the Oracle Real‐World Data database was queried for medical records that coincided with the clinical definitions. For our study, there were 64,523,460 individual medical records queried.ResultsPeriod prevalence rates were calculated for the following ED disorders: hypohidrotic ectodermal dysplasia, found to be 2.99 per 100,000; ectodermal dysplasia and immunodeficiency 1, 0.23 per 100,000; Clouston syndrome, 0.15 per 100,000; ectrodactyly ectodermal dysplasia and cleft lip/palate syndrome, 0.61 per 100,000; ankyloblepharon‐ectodermal defects‐cleft lip/palate syndrome, 0.36 per 100,000; focal dermal hypoplasia, 0.10 per 100,000; and incontinentia pigmenti, 0.88 per 100,000.ConclusionThis study established estimated period prevalence rates for several of the ectodermal dysplasia syndromes, and it demonstrated the feasibility of utilizing large multicenter databases of electronic health records, such as Oracle Real World Data.
A twin analysis to estimate genetic and environmental factors contributing to variation in weighted gene co‐expression network module eigengenes
Authors: Gillespie Nathan A. , Bell Tyler R. , Hearn Gentry C. , Hess Jonathan L. , Tsuang Ming T. , Lyons Michael J. , Franz Carol E. , Kremen William S. , Glatt Stephen J. 
Published: August 2024

AbstractMultivariate network‐based analytic methods such as weighted gene co‐expression network analysis are frequently applied to human and animal gene‐expression data to estimate the first principal component of a module, or module eigengene (ME). MEs are interpreted as multivariate summaries of correlated gene‐expression patterns and network connectivity across genes within a module. As such, they have the potential to elucidate the mechanisms by which molecular genomic variation contributes to individual differences in complex traits. Although increasingly used to test for associations between modules and complex traits, the genetic and environmental etiology of MEs has not been empirically established. It is unclear if, and to what degree, individual differences in blood‐derived MEs reflect random variation versus familial aggregation arising from heritable or shared environmental influences. We used biometrical genetic analyses to estimate the contribution of genetic and environmental influences on MEs derived from blood lymphocytes collected on a sample of N = 661 older male twins from the Vietnam Era Twin Study of Aging (VETSA) whose mean age at assessment was 67.7 years (SD = 2.6 years, range = 62–74 years). Of the 26 detected MEs, 14 (56%) had statistically significant additive genetic variation with an average heritability of 44% (SD = 0.08, range = 35%–64%). Despite the relatively small sample size, this demonstration of significant family aggregation including estimates of heritability in 14 of the 26 MEs suggests that blood‐based MEs are reliable and merit further exploration in terms of their associations with complex traits and diseases.
Tandem Solid‐Solution Phase Post‐Synthetic Modification of Porous Molecular Crystals for In‐Situ Generation of Fluorophores
Authors: Bi Han , Shi Yadong , Wang Tao , Deng Shengyong , Tang Ben Zhong , Wei Peifa 
Published: August 2024

AbstractConventional synthetic methods of organic luminescent molecules often involve labor‐intensive solution‐phase organic synthesis, which violate the principles of atom‐economic transformation. Post‐synthetic modification (PSM) offers a promising alternative, allowing direct transformation from one fluorophore to another. Although PSM is commonly implemented in extended frameworks, its application in porous molecular crystals remains challenging. Herein, we focus on utilizing porous molecular crystals, specifically tetraphenylethylene‐cored frameworks, as versatile platforms for tandem PSM reactions to customize organic fluorophores. The tailored skeleton design ensures both the formation of porous structures and the occurrence of tandem solid‐solution phase reactions while maintaining the solid state of reactants and products in each step. The inherent non‐covalent bonding nature of the frameworks facilitates processing and characterization, offering unparalleled advantages for porous networks. The accompanying solid‐state fluorescence transition from green to blue and then to green (or yellow) enables real‐time monitoring of tandem reactions and provides intuitive mechanistic insights. This phenomenon is exploited for the facile construction of a dynamic information encryption system using fluorescent quick response codes.
A Dual‐Focus Workflow for Simultaneously Engineering High Activity and Thermal Stability in Methyl Parathion Hydrolase
Authors: Li Yingnan , Fu Yuzhuang , Chen Xiling , Fan Shilong , Cao Zexing , Xu Fei 
Published: August 2024

AbstractIndustrial fermentation applications typically require enzymes that exhibit high stability and activity at high temperatures. However, efforts to simultaneously improve these properties are usually limited by a trade‐off between stability and activity. This report describes a computational strategy to enhance both activity and thermal stability of the mesophilic organophosphate‐degrading enzyme, methyl parathion hydrolase (MPH). To predict hotspot mutation sites, we assembled a library of features associated with the target properties for each residue and then prioritized candidate sites by hierarchical clustering. Subsequent in silico screening with multiple algorithms to simulate selective pressures yielded a subset of 23 candidate mutations. Iterative parallel screening of mutations that improved thermal stability and activity yielded, MPHase‐m5b, which exhibited 13.3 °C higher Tm and 4.2 times higher catalytic activity than wild‐type (WT) MPH over a wide temperature range. Systematic analysis of crystal structures, molecular dynamics (MD) simulations, and quantum mechanics/molecular mechanics (QM/MM) calculations revealed a wider entrance to the active site that increased substrate access with an extensive network of interactions outside the active site that reinforced αβ/βα sandwich architecture to improve thermal stability. This study thus provides an advanced, rational design framework to improve efficiency in engineering highly active, thermostable biocatalysts for industrial applications.
Gold(I)‐Catalyzed Desymmetrization of Homopropargylic Alcohols via Cycloisomerization: Enantioselective Synthesis of Cyclopentenes Featuring a Quaternary Chiral Center
Authors: Kohnke Philip , Zhang Liming 
Published: August 2024

AbstractCyclopentene rings possessing a chiral quaternary center are important structural motifs found in various natural products. In this work, we disclose expedient and efficient access to this class of synthetically valuable structures via highly enantioselective desymmetrization of prochiral propargylic alcohols. The efficient chirality induction in this asymmetric gold catalysis is achieved via two‐point bindings between a gold catalyst featuring a bifunctional phosphine ligand and the substrate homopropargylic alcohol moiety—an H‐bonding interaction between the substrate HO group and a ligand phosphine oxide moiety and the gold‐alkyne complexation. The propargylic alcohol substrates can be prepared readily via propargylation of enoate and ketone precursors. In addition to monocyclic cyclopentenes, spirocyclic and bicyclic ones are formed with additional neighboring chiral centers of flexible stereochemistry in addition to the quaternary center. This work represents rare gold‐catalyzed highly enantioselective cycloisomerization of 1,5‐enynes. Density functional theory (DFT) calculations support the chirality induction model and suggest that the rate acceleration enabled by the bifunctional ligand can be attributed to a facilitated protodeauration step at the end of the catalysis.