bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Facile Synthesis of Iron Oxide NPs as Magnetically Recyclable Catalysts for Chemoselective Synthesis of Pyrazolo[3,4‐b]pyridine‐5‐carbonitiles in Aqueous Medium under Ultrasonic Irradiation.
Authors: Dandia Anshu , Parewa Vijay , Sharma Amit , Rathore Kuldeep S. 
Published: April 2015

AbstractThe employed catalyst can be easily recovered by a magnetic field and reused five times without any loss of its high catalytic activity.
ChemInform Abstract: A Novel and Facile Synthesis of 2‐Oxo‐1,2‐dihydropyridine‐Fused 1,3‐Diazaheterocycles via Heterocyclic Ketene Aminals and Knoevenagel Adducts Formed by Phthalic Anhydride and Ethyl Cyanacetate.
Authors: Zou Min‐Ming , Zhu Feng‐Juan , Tian Xue , Ren Li‐Ping , Shao Xu‐Sheng , Li Zhong 
Published: April 2015

AbstractThis referred transformation presents a novel way for the construction of 2‐oxo‐1,2‐dihydropyridine‐fused 1,3‐diazaheterocycles.
ChemInform Abstract: An Efficient Synthesis of 1‐Oxo‐1,2‐dihydrobenzo[b][1,6]naphthyridine‐4‐carbonitriles.
Authors: Wang Dao‐Lin , Wu Jian‐Ying , Wu Dan , Wang Yong‐Yang 
Published: April 2015

AbstractThe title compounds (V) are obtained via tandem addition‐elimination‐cyclization reaction of quinoline‐3‐carboxylate derivatives (III) with primary amines (IV).
ChemInform Abstract: Broensted Acid Mediated Alkenylation and Copper‐Catalyzed Aerobic Oxidative Ring Expansion/Intramolecular Electrophilic Substitution of Indoles with Propargyl Alcohols: A Novel One‐Pot Approach to Cyclopenta[c]quinolines.
Authors: Gangadhararao G. , Uruvakilli Anasuyamma , Swamy K. C. Kumara 
Published: April 2015

AbstractThe method is not applicable to N‐unprotected indole derivatives.
ChemInform Abstract: An Unprecedented Tandem Annulation of ω‐Azido‐1‐alkynes with Diaryliodonium Salts: A Facile Synthesis of Polycyclic Quinolines.
Authors: Chen Junjie , Chen Chao , Chen Jing , Gao Hongpeng , Qu Hongmei 
Published: April 2015

AbstractThe copper‐catalyzed annulation of azidoalkynes with diaryliodonium triflates, serving as C‐2 building blocks, proceeds smoothly and under mild conditions.
ChemInform Abstract: Ultrasound‐Promoted One‐Pot Synthesis of 2‐Thioxo‐dihydropyrimidine Derivatives Bearing Piperidinylamide Moiety.
Authors: Chen Bao‐Hua , Li Ji‐Tai , Lan Rui‐Jia , Chen Guo‐Feng 
Published: April 2015

AbstractThe title compounds (IV) are obtained by convenient and efficient one‐pot condensation of 1,3‐dione (I) with various aromatic aldehydes (II) and thiourea (III) under mild reaction conditions.
ChemInform Abstract: Facile Synthesis of Novel N4‐Substituted 2‐(Trifluoromethyl)‐tetrahydrobenzothieno[ 2,3‐d]pyrimidine Derivatives.
Authors: Wang Fasong , Gao Hui , Yang Ping , Wang Yan , Song Xinjian 
Published: April 2015

AbstractThe title compounds are obtained by a facile three‐step synthesis starting from easily accessible starting materials under mild reaction conditions.
ChemInform Abstract: A Cascade of Acid‐Promoted C—O Bond Cleavage and Redox Reactions: From Oxa‐Bridged Benzazepines to Benzazepinones.
Authors: Zhang Yuewei , Yang Fengzhi , Zheng Lianyou , Dang Qun , Bai Xu 
Published: April 2015

AbstractThe synthetic potential of the method is demonstrated by the transformation of compound (X) into the drug tolvaptan (XI).
ChemInform Abstract: A Catalyst‐Free Synthesis of α‐Aminophosphonates in Glycerol.
Authors: Azizi Kobra , Karimi Meghdad , Heydari Akbar 
Published: April 2015

AbstractKabachnik—Fields reaction of carbonyl compounds, amines, and phosphites in glycerol as solvent affords α‐aminophosphonates in high yields.
ChemInform Abstract: Synthesis of a Common Cyclopentanoid Building Block for the Total Synthesis of Jatropha‐5,12‐ and ‐6(17),11‐dienes by Uncatalyzed Intramolecular Carbonyl Ene (ICE) Reaction.
Authors: Butt Lena , Hiersemann Martin 
Published: April 2015

AbstractKey intermediates (I) and (II) serve as building blocks for attempted syntheses of euphoheliosnoid D (III) and euphodendoridin D (IV).
ChemInform Abstract: Tirucallane‐Type Triterpenoids from Celastrus stylosus Wall.
Authors: Shan Wei‐Guang , Gao Zai‐Lin , Ying You‐Min , Xiang Jia‐Gui , Wang Fa‐Song , Zhan Zha‐Jun 
Published: April 2015

Abstractisolation and structure elucidation of two new tirucallane‐type triterpenoids (I) and (II)
ChemInform Abstract: Total Synthesis and Determination of the Absolute Configuration of Rakicidin A.
Authors: Chen Yue , et al.  
Published: April 2015

AbstractRakicidin A, a natural cyclic depsipeptide possessing unique growth inhibitory activity against chronic myelogenous leukemia stem cells is synthesized in a stereoselective fashion allowing the assignment of the absolute stereochemistry of its five chiral centers.
ChemInform Abstract: Flavonol Glycosides and Iridoids from Asperula lilaciflora
Authors: Kirmizibekmez Hasan , Bardakci Hilal , Masullo Milena , Kamburoglu Oezge , Eryilmaz Gonca , Akaydin Galip , Yesilada Erdem , Piacente Sonia 
Published: April 2015

Abstractisolation and structure elucidation of a new flavonol glycoside, named lilacifloroside (I), and a new iridoid, named asperulogenin (II), along with eight known compounds
ChemInform Abstract: Evollionines A—C, Three New Alkaloids Isolated from the Fruits of Evodia rutaecarpa.
Authors: Li Yan‐Hong , He Juan , Li Yan , Wu Xing‐De , Peng Li‐Yan , Du Ru‐Nan , Cheng Xiao , Zhao Qin‐Shi , Li Rong‐Tao 
Published: April 2015

AbstractThree new alkaloids, evollionines A (I), B (II), and C (III), are isolated together with two known compounds, evodianinine and wuzhuyumide I.
ChemInform Abstract: New Acetogenins from the Seeds of Annona coriacea.
Authors: da C. Alves Thayana , Goncalves Mariele R. S. , Correia Francyne C. S. , da Silva Virginia C. , de Sousa Paulo T. Jr. , de Carvalho Mario G. , Braz‐Filho Raimundo , Dall'Oglio Evandro L. 
Published: April 2015

Abstractisolation and structure elucidation of two novel acetogenins, coriapentocins A (I) and B (II)
ChemInform Abstract: Asymmetric Syntheses of (—)‐3‐epi‐Fagomine, (2R,3S,4R)‐Dihydroxypipecolic Acid, and Several Polyhydroxylated Homopipecolic Acids.
Authors: Csatayova Kristina , Davies Stephen G. , Fletcher Ai M. , Ford J. Gair , Klauber David J. , Roberts Paul M. , Thomson James E. 
Published: April 2015

AbstractThe target compounds are synthesized using diastereoselective olefinic oxidations of enantiopure tetrahydropyridines.
ChemInform Abstract: Flavonoids and Arylbenzofurans from the Rhizomes and Roots of Sophora tonkinensis with IL‐6 Production Inhibitory Activity.
Authors: Yoo Hunseung , Chae Hee‐Sung , Kim Young‐Mi , Kang Minseok , Ryu Keun Ho , Ahn Hee Chul , Yoon Kee Dong , Chin Young‐Won , Kim Jinwoong 
Published: April 2015

AbstractThree new flavenoids, 2′‐hydroxyglabrol (I), 3‐methylmaackiapterocarpan B (II), and (III), are isolated along with 20 known compounds from the rhizomes and roots of Sophora tonkinensis.
ChemInform Abstract: Tanzawaic Acid Derivatives from a Marine Isolate of Penicillium sp. (SF‐6013) with Antiinflammatory and PTP1B Inhibitory Activities.
Authors: Quang Tran Hong , Ngan Nguyen Thi Thanh , Ko Wonmin , Kim Dong‐Cheol , Yoon Chi‐Su , Sohn Jae Hak , Yim Joung Han , Kim Youn‐Chul , Oh Hyuncheol 
Published: April 2015

AbstractThe new tanzawaic acid derivative, 2E,4Z‐tanzawaic acid D (I), is isolated along with four known analogues from the marine‐derived fungus Penicillium sp.
ChemInform Abstract: γ‐(S)‐Trifluoromethyl Proline: Evaluation as a Structural Substitute of Proline for Solid State 19F‐NMR Peptide Studies
Authors: Kubyshkin Vladimir , Afonin Sergii , Kara Sezgin , Budisa Nediljko , Mykhailiuk Pavel K. , Ulrich Anne S. 
Published: April 2015

AbstractReview: [47 refs.
ChemInform Abstract: Comparative in Operando Studies in Heterogeneous Catalysis: Atomic and Electronic Structural Features in the Hydrogenation of Ethylene over Supported Pd and Pt Catalysts
Authors: Jung Ulrich , Elsen Annika , Li Yuanyuan , Smith Jeremy G. , Small Matthew W. , Stach Eric A. , Frenkel Anatoly I. , Nuzzo Ralph G. 
Published: April 2015

AbstractReview: 111 refs.
Metallo‐Deuteroporphyrin as a Biomimetic Catalyst for the Catalytic Oxidation of Lignin to Aromatics
Authors: Zhu Chenjie , Ding Weiwei , Shen Tao , Tang Chenglun , Sun Chenguo , Xu Shichao , Chen Yong , Wu Jinglan , Ying Hanjie 
Published: April 2015

AbstractA series of metallo‐deuteroporphyrins derived from hemin were prepared as models of the cytochrome P450 enzyme. With the aid of the highly active CoII deuteroporphyrin complex, the catalytic oxidation system was applied for the oxidation of several lignin model compounds, and high yields of monomeric products were obtained under mild reaction conditions. It was found that the modified cobalt deuteroporphyrin that has no substituents at the meso sites but does have the disulfide linkage in the propionate side chains at the β sites exhibited much higher activity and stability than the synthetic tetraphenylporphyrin. The changes in the propionate side chains can divert the reactivity of cobalt deuteroporphyrins from the typical CC bond cleavage to CO bond cleavage. Furthermore, this novel oxidative system can convert enzymolysis lignin into depolymerized products including a significant portion of well‐defined aromatic monomers.
MnCo2O4 Nanowires Anchored on Reduced Graphene Oxide Sheets as Effective Bifunctional Catalysts for Li–O2 Battery Cathodes
Authors: Kim Jong Guk , Kim Youngmin , Noh Yuseong , Kim Won Bae 
Published: April 2015

AbstractA hybrid composite system of MnCo2O4 nanowires (MCO NWs) anchored on reduced graphene oxide (RGO) nanosheets was prepared as the bifunctional catalyst of a Li–O2 battery cathode. The catalysts can be obtained from the hybridization of one‐dimensional MCO NWs and two‐dimensional RGO nanosheets. As O2‐cathode catalysts for Li–O2 cells, the MCO@RGO composites showed a high initial discharge capacity (ca. 11092.1 mAh gcarbon−1) with a high rate performance. The Li–O2 cells could run for more than 35 cycles with high reversibility under a limited specific capacity of 1000 mAh gcarbon−1 with a low potential polarization of 1.36 V, as compared with those of pure Ketjenblack and MCO NWs. The high cycling stability, low potential polarization, and rate capability suggest that the MCO@RGO composites prepared here are promising catalyst candidates for highly reversible Li–O2 battery cathodes.
Electrocatalytic Hydrogenation of 5‐Hydroxymethylfurfural in Acidic Solution
Authors: Kwon Youngkook , Birdja Yuvraj Y. , Raoufmoghaddam Saeed , Koper Marc T. M. 
Published: April 2015

AbstractElectrocatalytic hydrogenation of 5‐hydroxymethylfurfural (HMF) is studied on solid metal electrodes in acidic solution (0.5 M H2SO4) by correlating voltammetry with on‐line HPLC product analysis. Three soluble products from HMF hydrogenation are distinguished: 2,5‐dihydroxymethylfuran (DHMF), 2,5‐dihydroxymethyltetrahydrofuran (DHMTHF), and 2,5‐dimethyl‐2,3‐dihydrofuran (DMDHF). Based on the dominant reaction products, the metal catalysts are divided into three groups: (1) metals mainly forming DHMF (Fe, Ni, Cu, and Pb), (2) metals forming DHMF and DMDHF depending on the applied potentials (Co, Ag, Au, Cd, Sb, and Bi), and (3) metals forming mainly DMDHF (Pd, Pt, Al, Zn, In, and Sb). Nickel and antimony are the most active catalysts for DHMF (0.95 mM cm−2 at ca. −0.35 VRHE and −20 mA cm−2) and DMDHF (0.7 mM cm−2 at −0.6 VRHE and −5 mA cm−2), respectively. The pH of the solution plays an important role in the hydrogenation of HMF: acidic condition lowers the activation energy for HMF hydro‐genation and hydrogenates the furan ring further to tetrahydrofuran.
Identification and visualization of multidimensional antigen‐specific T‐cell populations in polychromatic cytometry data
Authors: Lin Lin , Frelinger Jacob , Jiang Wenxin , Finak Greg , Seshadri Chetan , Bart Pierre‐Alexandre , Pantaleo Giuseppe , McElrath Julie , DeRosa Steve , Gottardo Raphael 
Published: April 2015

AbstractAn important aspect of immune monitoring for vaccine development, clinical trials, and research is the detection, measurement, and comparison of antigen‐specific T‐cells from subject samples under different conditions. Antigen‐specific T‐cells compose a very small fraction of total T‐cells. Developments in cytometry technology over the past five years have enabled the measurement of single‐cells in a multivariate and high‐throughput manner. This growth in both dimensionality and quantity of data continues to pose a challenge for effective identification and visualization of rare cell subsets, such as antigen‐specific T‐cells. Dimension reduction and feature extraction play pivotal role in both identifying and visualizing cell populations of interest in large, multi‐dimensional cytometry datasets. However, the automated identification and visualization of rare, high‐dimensional cell subsets remains challenging. Here we demonstrate how a systematic and integrated approach combining targeted feature extraction with dimension reduction can be used to identify and visualize biological differences in rare, antigen‐specific cell populations. By using OpenCyto to perform semi‐automated gating and features extraction of flow cytometry data, followed by dimensionality reduction with t‐SNE we are able to identify polyfunctional subpopulations of antigen‐specific T‐cells and visualize treatment‐specific differences between them. © 2015 The Authors. Published by Wiley Periodicals, Inc.
Flow cytometric analysis of intracellular phosphoproteins in human monocytes
Authors: Coppin Emilie , Malergue Fabrice , Thibult Marie‐Laure , Scifo Caroline , Favre Cédric , Nunès Jacques A. 
Published: April 2015

BackgroundUsing antibodies against intracellular phosphoproteins, flow cytometry can be used to monitor simultaneously multiple signaling pathways. Here, we tested a recently released procedure to analyze phosphorylation events in human monocytes upon different types of stimulation.MethodsWhole blood was treated by lipopolysaccharide (LPS) or granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), then cells were labeled by antibodies recognizing cell surface and cytosolic proteins. Human monocytes were identified by a CD14 – CD45 staining and three phosphorylated proteins such as AKT, ERK‐1/2, and STAT5, were simultaneously detected by multicolor phosphoflow analysis.ResultsBy this rapid method, we are able to detect directly from a blood sample several signaling events in human monocytes where LPS stimulation induces preferentially ERK‐1/2 phosphorylation where as GM‐CSF stimulation induces STAT5 phosphorylation.ConclusionsThis procedure provides a simultaneous measurement of multiple activated signaling molecules using a simplified and rapid protocol. © 2015 International Clinical Cytometry Society
Tin Oxometallates from the Hydrolysis of SnMe22+ in the Presence of 2,6‐Lutidine‐α2,3‐diol and Different Anions
Authors: Casas José S. , Castiñeiras Alfonso , Condori Félix , Couce María D. , Sánchez Agustín , Sordo José , Vázquez‐López Ezequiel 
Published: April 2015

AbstractThe reaction of the dimethyltin(IV) cation with 2,6‐lutidine‐α2,3‐diol (Lut, 2‐hydroxymethyl‐3‐hydroxy‐6‐methylpyridine) has been investigated in ethanol/water mixtures (80:20 v/v) containing Cl– and NO3–, NO3– and OAc– or Cl– and OAc– ions in various molar ratios. From these reactions, several tin oxometallates were isolated and characterized by IR, Raman, 1H NMR, 13C NMR and 119Sn NMR spectroscopy as well as ESI‐MS. The crystal structures of the compounds [Lut+H]Cl·H2O, [(SnMe2)4O2(Lut‐H)2Cl2] (1), [SnMe2(Lut‐H)Cl] (2), [(SnMe2)3O(Lut‐H)2Cl]Cl (3), [(SnMe2)3O(Lut‐H)2Cl2]·H2O (4·H2O) and [(SnMe2)4O2(Lut‐H)2(NO3)2] (5) were determined by X‐ray diffractometry. The structure of 2 contains dimeric [SnMe2(Lut‐H)Cl]2 units based on a central Sn2O2 fragment, the Lut ligand is monodeprotonated, and both the tin atoms are hexacoordinate. The other metallates are all tri‐ or tetranuclear and show the dimethyltin(IV) unit in several penta‐ or hexacoordinate environments. The C–OH group of the Lut‐H fragment, the Cl atoms, the O atoms of the nitrate group and the water molecules (for 4·H2O) are involved in hydrogen bonds, which modulate the interactions between the units and the packing in the crystal. The NMR and ESI‐MS spectra show the existence of complex equilibria in solution.
Heterocyclic Digallanates, Encapsulation of Lithium Cations in Organometallic Cages and C–H Bond Activation
Authors: Uhl Werner , Hentschel Anne , Kovert Dirk , Kösters Jutta , Layh Marcus 
Published: April 2015

AbstractHydrogallation of the dialkynylbenzenes 1,3‐(R2R′Si‐C≡C)2C6H4 (3: R = Me, R′ = Ph; 4: R = Ph, R′ = Me) with dichlorogallane, H‐GaCl2, afforded the corresponding dialkenylbenzenes 5 and 6, with GaCl2 groups geminal to the silyl substituents. Compound 6 was characterised by crystal structure determination, which revealed intramolecular bridging of both gallium atoms by two chlorine atoms as a new structural motif. Treatment of 5 and 6 with six equivalents of ethyllithium gave unprecedented heterocyclic digallanates 7 and 8, in which two four‐coordinate gallium atoms were bridged by two 1,3‐dialkenylbenzene spacer ligands. The obtained large heterocycles encapsulated two lithium counterions in their molecular cavities. The lithium atoms were coordinated in a cryptand‐like fashion and showed a variety of short contacts to aromatic rings, alkenyl groups, and α‐carbon atoms of terminal ethyl groups. They could be removed from the molecular cavity by coordination with chelating 1,2‐dimethoxyethane ligands. Heating of digallanates 7 and 8 in toluene to more than 100 °C over a period of 5 h resulted in fascinating transformations with C–H bond activation and ortho‐metallation. Five‐membered GaC4 metallacycles were formed, which had a terminal R2R′Si‐CH=CH‐ group resulting from the formal protolytic cleavage of an alkenyl–gallium bond by the ortho‐hydrogen atom.
Synthesis of Binary Sb2E3 (E = S, Se) and Ternary Sb2(S,Se)3 Nanowires Using Tailor‐Made Single‐Source Precursors
Authors: Heimann Stefan , Assenmacher Wilfried , Prymak Oleg , Schulz Stephan 
Published: April 2015

AbstractThermal decomposition of four single‐source precursors of the type (Et2Sb)2E and Et3SbE (E = S, Se) at 170 °C in the presence of suitable capping agents yielded binary Sb2S3 and Sb2Se3 nanowires. In addition, simultaneous decomposition of (Et2Sb)2S and(Et2Sb)2Se gave the ternary phase Sb2(S,Se)3 with almost equal S and Se concentrations. The materials were characterized by XRD, REM, EDX, ED and HRTEM.
A Flexible Route to Indole Scaffolds – Formal Synthesis of (±)‐Mersicarpine
Authors: Pfaffenbach Magnus , Gaich Tanja 
Published: April 2015

AbstractThe formal synthesis of racemic mersicarpine was accomplished in an operationally simple, reliable, and efficient manner in eight isolated steps. The use of a common intermediate increases the degree of synthetic flexibility and allows the construction of two completely different polycyclic alkaloid skeletons.
Cloud broker service‐oriented resource management model
Authors: Aazam Mohammad , Huh Eui‐Nam 
Published: April 2015

AbstractWith the increasing digital media content, cloud computing's importance is scaling up very fast. It provides ease of management for the growing media content. Besides this, features like ubiquitous access, service creation, service discovery and resource provisioning play a significant role. Cloud arena is going beyond this now, and the next era is of cloud federation. Services would be brought up together to the user through multiple clouds, known as cloud federation or intercloud computing. Although still in its infancy, intercloud computing is meant to provide more scalable, efficient and better managed services. Cloud broker is an important feature of intercloud computing, which plays its role in terms of resource management, service discovery, service‐level agreement negotiation and match making between service provider(s) and customer(s). The already performed studies have trivially addressed brokerage in intercloud environment, and no complete resource management model is presented so far. In this study, we present a detailed service‐oriented dynamic resource management model, which covers the issues of resource prediction, customer type‐based resource estimation and reservation, advanced reservation, pricing, refunding and acquired quality of service‐based refunding. We have implemented our system in Java/NetBeans 8.0 (Oracle Corporation) and evaluated through CloudSim 3.0.3 (The CLOUDS Lab, The University of Melbourne, Australia) toolkit, on 11 parameters. Our methodology was modelled on Google Cluster trace of 12 000 machines. The results and discussion show the validity and performance of our system. Copyright © 2015 John Wiley & Sons, Ltd.
A mesh‐adaptative metric‐based full multigrid for the Poisson problem
Authors: Brèthes Gautier , Allain Olivier , Dervieux Alain 
Published: April 2015

SummaryThis paper studies the combination of the full‐multigrid (FMG) algorithm with an anisotropic metric‐based mesh adaptation algorithm. For the sake of simplicity, the case of an elliptic two‐dimensional partial differential equation is studied. Meshes are unstructured and non‐embedded, defined through the metric‐based parameterization. A rather classical MG preconditioner is applied, in combination with a quasi‐Newton fixed point. An anisotropic metric‐based mesh adaptation loop is introduced inside the FMG algorithm. FMG convergence stopping test is revisited. Applications to a few two‐dimensional continuous and discontinuous coefficient elliptic model problems show the efficiency of this combination. Copyright © 2015 John Wiley & Sons, Ltd.
Determinants of US Prescription Drug Utilization using County Level Data
Authors: Nianogo Thierry , Okunade Albert , Fofana Demba , Chen Weiwei 
Published: April 2015

SummaryPrescription drugs are the third largest component of US healthcare expenditures. The 2006 Medicare Part D and the 2010 Affordable Care Act are catalysts for further growths in utilization becuase of insurance expansion effects. This research investigating the determinants of prescription drug utilization is timely, methodologically novel, and policy relevant. Differences in population health status, access to care, socioeconomics, demographics, and variations in per capita number of scripts filled at retail pharmacies across the USA justify fitting separate econometric models to county data of the states partitioned into low, medium, and high prescription drug users. Given the skewed distribution of per capita number of filled prescriptions (response variable), we fit the variance stabilizing Box–Cox power transformation regression models to 2011 county level data for investigating the correlates of prescription drug utilization separately for low, medium, and high utilization states. Maximum likelihood regression parameter estimates, including the optimal Box–Coxλpower transformations, differ across high (λ = 0.214), medium (λ = 0.942), and low (λ = 0.302) prescription drug utilization models. The estimated income elasticities of −0.634, 0.031, and −0.532 in high, medium, and low utilization models suggest that the economic behavior of prescriptions is not invariant across different utilization levels. Copyright © 2015 John Wiley & Sons, Ltd.