bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Custom-Made Designed and 3D-Printed Wrist-Driven Orthoses on Grasp Strength of Lost Hand Function
Authors: Acar Ahmet Gökhan , Alsancak Serap 
Published: July 2024

Abstract

Introduction
Wrist-driven orthoses can be used in people who have lost their hand functions to a certain extent. The orthoses are designed to harness residual wrist power and convert it with a mechanism to move the fingers. We developed 3D-printed wrist-driven orthoses for spastic hands and improved three-point grasp between thumb and index-middle fingers’ function.

Methods
Three orthoses were designed and manufactured for two participants with and without extension assists according to children’s needs. This study presents 3D designing and printing of three orthoses and investigates the effectiveness on the pinch force and daily living activities for participants with loss of hand function.

Results
Custom-made 3D-printed wrist-driven orthoses that provide hand function and are functional, lightweight, and aesthetically pleasing were manufactured in a shorter duration than conventional orthoses.

Discussion
This technique is acceptable and improves function of spastic and different traumatically injured hands. A wrist-driven orthosis was used in the treatment of 2 patients. It was found that the pinch force and the performance in daily living activities had increased. Complete joint alignment was guaranteed, and the orthoses were aesthetically pleasing and light.

Clinical Relevance
This study is clinically relevant since it gives a suitable, easy to produce, modifiable, economic orthosis design while continuing to provide comfortable, durable, and lightweight design.
Superior Canal Dehiscence and the Risk of Additional Dehiscences: A Retrospective CT Cohort Study
Authors: Shankar Ahjeetha , Nagururu Nimesh V. , Pearl Monica S. , Shankar Adeethyia , Carey John P. , Ward Bryan K. 
Published: July 2024

Objective
Determine if superior canal dehiscence (SCD) found on flat-panel CT increases the risk for other defects in the otic capsule.

Study Design
Retrospective cohort study.

Setting
Tertiary care center.

Patients
One hundred ears (50 with SCD and 50 matched controls without SCD).

Interventions
Flat-panel CT imaging.

Main Outcome Measures
(1) Prevalence of other dehiscences in SCD ears, (2) dehiscences in controls, and (3) otic capsule thickness in other reported dehiscence locations (cochlea-carotid, lateral semicircular canal [SCC] and mastoid, facial nerve-lateral SCC, vestibular aqueduct, posterior SCC-jugular bulb, posterior SCC-posterior fossa). Between-group comparisons were considered significant at p < 0.007 after applying the Bonferroni correction for multiple comparisons.

Results
Not including the SCD, there was a mean of 0.04 additional dehiscences in the SCD group (n = 2/50, 4%) and 0.04 non-SCD dehiscences in the controls (n = 2/50, 4%, p > 0.007). In the SCD group, there was one dehiscence between the cochlea and carotid artery and one between the posterior SCC and posterior fossa. The control group had one enlarged vestibular aqueduct and one dehiscence between the facial nerve and lateral SCC. As a group, SCD ears had wider vestibular aqueducts (0.68 ± 0.20 vs 0.51 ± 0.30 mm, p < 0.007) and thinner bone between the posterior SCC and posterior fossa (3.12 ± 1.43 vs 4.34 ± 1.67 mm, p < 0.007). The bone between the facial nerve and lateral SCC was thicker in SCD ears (0.77 ± 0.23 vs 0.55 ± 0.27 mm, p < 0.007) and no different for cochlea-carotid, and lateral SCC and mastoid (p > 0.007).

Conclusions
SCD does not increase the likelihood of a second dehiscence in the same otic capsule. SCD patients may have congenitally thinner otic capsule bones compared to controls, particularly near the posterior SCC, where the vestibular aqueduct may be enlarged.
Factors Affecting Speech Discrimination After Vestibular Schwannoma Resection
Authors: Kalmanson Olivia , Olson Madeline , Ovard Olivia , Freeman Lindsey , Ung Timothy H. , Hogan Elizabeth , Cass Stephen , Youssef A Samy , Gubbels Samuel 
Published: July 2024

Objective
Investigate the relationship between word recognition score (WRS) and pure tone average (PTA) after hearing preservation surgery for vestibular schwannomas (VS) as well as evaluate the consistency of hearing classification systems.

Study Design
A retrospective chart review was performed.

Setting
This study included patients from a single academic tertiary referral hospital.

Patients
Patients with VS and serviceable hearing who underwent hearing preservation surgery 2014–2023. Patients excluded for neurofibromatosis 2 and lacking pre/postop audiograms.

Intervention(s)
All patients underwent resection of vestibular schwannoma.

Main Outcome Measure(s)
Pre/postop WRS, PTA, and AAO-HNS, Gardner-Robertson (GR), and WRS Class (WRSC) hearing classifications.

Results
Seventy-five patients were included. Average preop and postop PTA and WRS were 26 ± 12 dB, 79 ± 39 dB, 92 ± 12%, and 33 ± 43%, respectively. Postop PTAs were distributed along the complete testable decibel range, while the postop WRS displayed a bimodal distribution, with WRS >50% or <20%. Worsening intraop ABR changes were significantly associated with poorer hearing outcomes (p = 0.005). With increasing Koos grades, intraop ABRs were significantly more likely to exhibit changes (p = 0.005). AAO-HNS and GR classified patients nearly identically, while the WRSC resulted in more class I and fewer class II. The cutoff of serviceable hearing was comparable across all classification systems.

Conclusions
Effects on the brainstem component of Koos 3–4 tumors may particularly disturb speech processing. This effect seems amplified by surgical dissection. AAO-HNS, GR, and WRSC hearing classifications are comparable in describing serviceable hearing in vestibular schwannoma patients.
Micronutrient deficiencies in inflammatory bowel disease: an incidence analysis
Authors: Kamel Amir Y. , Johnson Zachary D. , Hernandez Isabela , Nguyen Christine , Rolfe Melanie , Joseph Tiffany , Dixit Devika , Shen Steve , Chaudhry Naueen , Pham Angela , Rampertab S. Devi , Zimmermann Ellen 
Published: July 2024

Background
Micronutrient deficiencies associated with malnutrition in patients with inflammatory bowel disease (IBD) can lead to complications including anemia, coagulopathy, poor wound healing, and colorectal cancer. This study aimed to investigate micronutrient deficiencies (copper, vitamins A, B9, E, and K) in IBD patients and highlight associated symptoms to aid in the recognition of micronutrient deficiencies.

Methods
A retrospective electronic chart review was performed on adults diagnosed with Crohn’s disease or ulcerative colitis hospitalized at a tertiary care center for IBD flare between January 2013 and June 2017. Patients with serum or whole blood micronutrient levels were included. Pregnant and incarcerated patients were excluded.

Results
A total of 611 IBD patients (440 Crohn’s disease, 171 ulcerative colitis) met the inclusion criteria. Micronutrients were assessed in a subset of IBD patients (copper: 12.3%, A: 10.1%, B9 : 95.9%, E: 10.3%, and K: 4.6%). Overall, 10.1% of patients had micronutrient deficiencies. The proportion of patients with copper, A, B9, E, and K deficiencies were 25.4, 53.3, 1.9, 23.7, and 29.4% for Crohn’s disease and 50, 52.9, 1.2, 43.8, and 18.2% for ulcerative colitis, respectively. The most common symptoms or historical features associated with micronutrient deficiency were anemia (copper, B9), muscle weakness (copper, E) thrombocytopenia, fatigue (copper, B9), diarrhea (B9), dry skin, hyperkeratosis, pruritus, significant weight loss, elevated C-reactive protein (A), bleeding, and osteoporosis (K).

Conclusion
Micronutrient deficiencies are common in IBD patients, yet they are not routinely assessed. Copper, vitamins A, E, and K deficiencies are particularly underrecognized. Associated historical features should raise suspicion and prompt assessment and treatment.
Feasibility and long-term outcomes of hepatic vein recanalization in Budd–Chiari syndrome through intrahepatic collateral pathways
Authors: Ma Hongru , Gou Yabo , Wang Chao , Xiao Jinchang , Shen Bin , Liu Hongtao , Huang Qianxin , Xu Hao , Zu Maoheng , Zhang Qingqiao 
Published: July 2024

Background and aims
To investigate the feasibility and long-term outcomes of hepatic vein (HV) recanalization using intrahepatic collateral pathways in patients with Budd–Chiari syndrome (BCS) with HV obstruction.

Methods
Clinical data of 29 BCS patients with HV obstruction and intrahepatic collateral pathways were reviewed. All patients underwent HV recanalization through the intrahepatic collaterals. Follow-up was performed at 1, 3, 6, and 12 months after treatment and annually thereafter. Cumulative patency and survival rates were assessed using Kaplan–Meier curves. The independent predictors of patency were determined using a Cox regression model.

Results
HV recanalization was successful in 28 of the 29 patients (96.6%), with no complications. Of the 28 cases, simultaneous recanalization of the accessory HV and right HV was achieved in 11 patients, accessory HV and middle HV in six, accessory HV and left HV in three, right HV and middle HV in five, and left HV and middle HV in three. Twenty-eight patients were followed from 4 to 87 (mean, 53.6 ± 26.7) months after treatment, and six patients developed reocclusion. The overall cumulative 1-, 3-, 5-, and 7-year primary HV patency rates were 96.3, 82.9, 74.6, and 59.7%, respectively. The cumulative 1-, 3-, 5-, and 7-year survival rates were 100, 95.8, 95.8, and 86.3%, respectively.

Conclusion
Interventional treatment of HV obstruction in BCS patients through intrahepatic collateral approaches is well tolerated and feasible and can result in excellent long-term patency and survival rates.
Quantitative bone single photon emission computed tomography/computed tomography in symptomatic and asymptomatic foot and ankle osteoarthritis
Authors: Ulrich Martin , Lehnick Dirk , Strobel Klaus , Grünig Hannes , Lima Thiago , Iselin Lukas , Bhure Ujwal 
Published: July 2024

Purpose
The purpose of this study was to evaluate and quantify the prevalence of increased uptake in SPECT/CT in symptomatic and asymptomatic foot and ankle joints in patients with osteoarthritis.

Methods
In 63 patients with osteoarthritis (OA), the painful symptomatic foot (SF) and asymptomatic contralateral foot (AF) were imaged with bone SPECT/CT. Presence, localization, and maximum standardized uptake value (SUVmax) of the active joints were assessed for SF and AF. CT OA grade (grade 1: mild, grade 2: moderate, grade 3: severe) and presence of five morphological features of OA (joint space narrowing, subchondral sclerosis, subchondral cysts, irregular joint margins, and osteophytes) were evaluated.

Results
In total 32 (51%) patients showed additional uptake in the AF, whereas 31 (49%) patients showed it only in the SF. SF showed more active joints than AF (106 vs. 43). CT OA grades positively correlated with SUVmax (Kendall’s tau b = 0.62, P < 0.001). SUVmax values (per foot) in SF were higher in patients with uptake in bilateral feet (SF+, AF+) [median (IQR): 17.9 (10.7–23.3)] as compared with patients with active sites only in the SF (SF+, AF−) [10.4 (6.4–19.1); P < 0.001]. Number of active OA joints in SF was higher in patients with bilateral uptake (P = 0.017).

Conclusion
In conclusion, half of the patients exhibited increased uptake in the contralateral asymptomatic foot. SUVmax showed a significant correlation to CT osteoarthritis grade, in the symptomatic and asymptomatic foot. Future follow-up studies will provide further insights into the prognostic and therapeutic value of these findings.
Complement protein expression changes in various conditions of breast cancer: in-silico analyses—experimental research
Authors: Zabihi Mohammad Reza , Farhadi Bahar , Akhoondian Mohammad 
Published: July 2024

Introduction:
Breast cancer is the most prevalent cancer diagnosed in females worldwide. The known biomarkers are insufficient to understand the actual prognosis of breast cancer, and identifying new biomarkers is desirable and valuable data to improve the patient’s survival. Many inflammatory biomarkers, such as the complement system, can be regarded as prognostic values and as potent inflammatory mediators; complement proteins have a critical role in tumorigenesis. In the current study, the authors aim to investigate complement protein expression changes, particularly complement 3 (C3), complement 7 (C7), complement factor B (CFB), and complement factor D (CFD), in various conditions of breast cancer using in-silico tools.

Methods:
The intent data were extracted using webtools, including; Kaplan–Meier plotter, BcGenExMiner, UALCAN, cbioportal, GeneMania, and Enrichr. To select valid data, a P greater than 0.05 was considered.

Results:
The current study clarified that 21 complement genes correlated to survival conditions. Also, down or upregulation of extracted genes and breast cancer statuses were identified. Additionally, expression level difference of complement genes in various breast cancer four stages was detected. Ultimately, co-expression genes with complement genes were extracted and networked.

Conclusion:
Changes in the expression of complement proteins can strongly correlate to breast cancer’s prognosis, status, and survival. Furthermore, considering the vital role of CFD and CFB complement proteins in the alternative pathway in different stages of breast cancer, CFD and CFB can be regarded as reliable prognostic values for diagnosis.
Reverse Takotsubo cardiomyopathy in the setting of small bowel obstruction: a case report
Authors: Bishev Daniel , Noureldine Hussein , Ortiz Fernando 
Published: July 2024

Introduction and importance:
Stress cardiomyopathy refers to a syndrome of acute but reversible left ventricular dysfunction, often triggered by emotional or physical stress. Reverse Takotsubo cardiomyopathy is an uncommon variant that occurs in about 5% of cases. Classically, it has been known to be following a catecholamine surge due to physical or emotional stress. This case highlights the importance for physicians to be aware of the possibility of developing stress cardiomyopathy in patients with acute intra-abdominal processes.

Case presentation:
Forty-one-year-old Caucasian female with was admitted with an acute small bowel obstruction. After failing conservative management, it was decided to proceed with surgery. After induction with anesthesia but prior to the surgeons first incision, the patient developed a tachyarrhythmia with hemodynamic compromise requiring the surgery to be aborted. That evening, she developed chest pain with concerns for an acute coronary syndrome. She was taken urgently to the for invasive angiography, which demonstrated reverse Takotsubo.

Clinical discussion:
Intra-abdominal processes and intubation have previously been reported be catalyst for this disease process. This patient had multiple stressors including mechanical bowel obstruction and anesthesia after failing conservative management. The diagnosis was confirmed by coronary angiography and left ventriculogram, and followed up with repeat outpatient echocardiography.

Conclusion:
A case of small bowel obstruction that developed reverse Takotsubo preceded by sustained ventricular tachycardia after intubation. The patient did well and had complete recovery cardiac function. Risk factors and underlining mechanism for the different variants of stress cardiomyopathy are not well understood, further investigation is warranted.
Burned-Out Testicular Carcinoma Presenting as Inferior Vena Cava Tumor Thrombus With Pulmonary Tumor Embolism on FDG PET/CT
Authors: Shani Shrem Noa , Levin Daniel , Rouvinov Keren , Ben-Arie Gal , Liberzon Ilya , Hod Nir 
Published: July 2024

Abstract
“Burned-out” testicular tumor is a very rare clinical phenomenon, which refers to the presence of a metastatic germ cell tumor with no clinical findings in the testicle due to spontaneous regression of the primary testicular lesion. We present an unusual case of burned-out testicular embryonal germ cell carcinoma presenting as an extensive inferior vena cava tumor thrombus with malignant pulmonary embolism in which FDG PET/CT played a pivotal role in detecting the extent and significance of the disease.
Pressorum Sensing: Growth-induced Compression Activates cAMP Signaling inPseudomonas aeruginosa
Authors: Ni Lei , Huang Yajia , Huang Yaoxin , Yu Yue , Xiong Jiarui , Wen Hui , Xiao Wenwen , Liang Haiyi , Jin Fan 
Published: July 2024

AbstractBacteria employ various strategies to coordinate population-level behaviors, with quorum sensing being a well-established mechanism. Here, we report a novel population-level regulatory mechanism inPseudomonas aeruginosa, which we term ‘pressorum sensing’. This mechanism allows bacteria to modulate their collective behavior in response to growth-induced mechanical compression in confined spaces. Using a highly sensitive cAMP biosensor in combination with microfluidics, we demonstrate that when compressive forces reach approximately 30 nN,P. aeruginosacells rapidly increases intracellular cAMP levels via the Pil-Chp chemosensory system. This response leads to up-regulation of the Type III Secretion System, a key virulence factor. Unlike quorum sensing, which relies on diffusible chemical signals, pressorum sensing utilizes mechanical cues to gauge population density and spatial confinement. In bacterial colonies, this mechanism generates striking spatial patterns of cAMP signaling, including traveling rings that coincide with step-like structures in colony morphology. Our findings reveal a previously unknown link between mechanical compression and bacterial virulence, providing new insights into howP. aeruginosacoordinates population-level responses in confined environments. This work also expands our knowledge of mechanogenetics and opens up new possibilities in synthetic biology and bioengineering applications.
Core outcome set for clinical trials of stent implantation in coronary heart disease -- a systematic review and mixed-method consensus study
Authors: Wan Xingli , Wang Xinyi , Li Xia , Long Youlin , Li Zhengchi , Du Liang 
Published: July 2024

ABSTRACTBackgroundAlthough various types of stent interventions have been found in clinical trials to be effective in treating coronary heart disease, researchers often use heterogeneous outcome measures. This can preclude the comparison of results across studies and prevent effective meta-analyses from answering important clinical questions. The need to standardize outcome measure reporting is urgent. This study aims to produce a core outcome set(COS) for coronary stent implantation research.MethodsWe performed a systematic review via the PubMed and EMBASE databases and then synthesized recommendations from international standardized endpoint definitions and consensus documents to generate a list of potential outcomes. We conducted a two-round Delphi survey, achieving the iterative selection of potential outcomes. A multidisciplinary panel of experts and patients with coronary stent implantation experience rated the importance of candidate outcomes on a 9-point Likert scale. To be provisionally accepted, outcomes needed to be critical important (score 7-9, with 9 being the maximum) by 70% of each stakeholder group. Finally, we held a consensus meeting to discuss and generate the COS.ResultsA total of seventy-two potential outcomes were identified by systematic literature review. We obtained nine key consensus documents to inform the standardized definitions of the outcomes. After duplication and combination of similar outcomes, 26 of the 72 outcomes assigned into five outcome domains were included in the Delphi surveys. Twenty outcomes were provisionally accepted. Following the consensus meetings, the agreement was reached on a twelve-item COS.ConclusionWe developed a COS for coronary stent implantation in coronary heart disease. Its implementation will facilitate the standardization reporting of clinical trials and reduce the heterogeneity in assessment in future research. Further research may help determine the specific, validated measurement instruments to assess each outcome.What is KnownCoronary stent implantation is consider to be the primary method for treating coronary heart disease.Many trials use heterogeneous effectiveness and safety outcome measures with different defined and non-patient concerned outcome measures, which would largely prevent meta-analyses and contribute to selective reporting bias.What the Study AddsWe initially develop the first core outcome set(COS) of coronary stent implantation intervention for China to facilitate the standardization reporting of clinical trials and enable meta-analysis.In our study, patient concerned outcome measure were thoroughly discussed and included in the COS by extensively involved patient representatives in every step of the project.Although we used rigorous method to development the COS, it should be updated as new evidence emerges in this rapidly evolving field.
Eastern Diet - a healthful dietary pattern from Eastern China: Its characteristics and relation to adiposity, cardiometabolic diseases, mortality, and gut microbiota
Authors: Shi Yuwei , Kan Juntao , Li Xinmei , Yu Yuji , Yuan Changzheng , Jiang Ying , Wu Qiaoyu , Hao Yufan , Wang Ningling , Wang Wenjie , Huang Emma Yunzhi , Zheng Weifang , Yang Fei , Wu Joyce , Myers April , Hsing Ann W. , Du Jun , He Wei , Zhu Shankuan 
Published: July 2024

AbstractAimThe dietary pattern in the downstream Yangtze River region of Eastern China has garnered widespread attention for its potential health benefits but lacks empirical evidence. This study aimed to identify and characterize this dietary pattern, develop a dietary pattern index, and evaluate its associations with adiposity, cardiometabolic diseases (CMDs), mortality, and gut microbiota.MethodsThis study used data from 8665 participants aged 18-80 years in the WELL-China cohort (2016-2019, Hangzhou, Eastern China) as the discovery cohort. K-means clustering identified an “Eastern Diet” (EastDiet) pattern and an adherence index based on the 12 food groups and flavor preferences were developed. Adiposity was measured using dual-energy X-ray absorptiometry. Incident CMDs and mortality were tracked through June 2024. Validation involved two external cohorts.ResultsThe EastDiet pattern was identified characterizing by high plant-based and aquatic food consumption, low refined grains and red meat intake, and a high preference for light-flavored. EastDiet index was favorably associated with lower adiposity. Comparing the highest to the lowest adherence tertiles, hazard ratios (HRs) for CMDs, type 2 diabetes, and cardiovascular diseases were 0.75 (95% CI: 0.62-0.90), 0.76 (0.60-0.96), and 0.71 (0.53-0.94), respectively. All-cause mortality was similarly reduced. Gut microbiota profiles associated with higher EastDiet adherence were linked to improved adiposity and reduced CMDs risk. Validation cohorts replicated these findings.ConclusionThis study identified and characterized the EastDiet pattern from Eastern China and determined its health benefits. Our findings highlighted the potential of the EastDiet as a healthful dietary pattern for Chinese population.