bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reptile responses to fire across the western Mediterranean Basin
Authors: Santos Xavier , Chergui Brahim , Belliure Josabel , Moreira Francisco , Pausas Juli G. 
Published: July 2024

AbstractEffects of anthropogenic activities, including climate change, are modifying fire regimes, and the dynamic nature of these modifications requires identification of general patterns of organisms’ responses to fire. This is a challenging task because of the high complexity of factors involved (including climate, geography, land use, and species‐specific ecology). We aimed to describe the responses of the reptile community to fire across a range of environmental and fire‐history conditions in the western Mediterranean Basin. We sampled 8 sites that spanned 4 Mediterranean countries. We recorded 6064 reptile sightings of 36 species in 1620 transects and modeled 3 community metrics (total number of individuals, species richness, and Shannon diversity) as responses to environmental and fire‐history variables. Reptile community composition was also analyzed. Habitat type (natural vs. afforestation), fire age class (time since the last fire), rainfall, and temperature were important factors in explaining these metrics. The total number of individuals varied according to fire age class, reaching a peak at 15–40 years after the last fire. Species richness and Shannon diversity were more stable during postfire years. The 3 community metrics were higher under postfire conditions than in unburned forest plots. This pattern was particularly prevalent in afforested plots, indicating that the negative effect of fire on reptiles was lower than the negative effect of afforestation. Community composition varied by fire age class, indicating the existence of early‐ and late‐successional species (xeric and saxicolous vs. mesic reptiles, respectively). Species richness was 46% higher in areas with a single fire age class relative to those with a mixture of fire age classes, which indicates pyrodiverse landscapes promoted reptile diversity. An expected shift to more frequent fires will bias fire age distribution toward a predominance of early stages, and this will be harmful to reptile communities.
Uncertainty in consensus predictions of plant species' vulnerability to climate change
Authors: Rose Miranda Brooke , Velazco Santiago José Elías , Regan Helen M. , Flint Alan L. , Flint Lorraine E. , Thorne James H. , Franklin Janet 
Published: June 2024

AbstractAimVariation in spatial predictions of species' ranges made by various models has been recognized as a significant source of uncertainty for modelling species distributions. Consensus approaches that combine the results of multiple models have been employed to reduce the uncertainty introduced by different algorithms. We evaluate how estimates of habitat suitability, projected using species distribution models (SDMs), varied among different consensus methods relative to the variation introduced by different global climate models (GCMs) and representative concentration pathways (RCPs) used for projection.LocationCalifornia Floristic Province (California, US portion).MethodsWe modelled the current and future potential distributions of 82 terrestrial plant species, developing model predictions under different combinations of GCMs, RCPs, time periods, dispersal assumptions and SDM consensus methods commonly used to combine different species distribution modelling algorithms. We assessed how each of these factors contributed to the variability in future predictions of species habitat suitability change and aggregate measures of proportional change in species richness. We also related variability in species‐level habitat change to species' attributes.ResultsAssuming full dispersal capacity, the variability between habitat predictions made by different consensus methods was higher than the variability introduced by different RCPs and GCMs. The relationships between species' attributes and variability in future habitat predictions depended on the source of uncertainty and dispersal assumptions. However, species with small ranges or low prevalence tended to be associated with high variability in range change forecasts.Main ConclusionsOur results support exploring multiple consensus approaches when considering changes in habitat suitability outside of species' current distributions, especially when projecting species with low prevalence and small range sizes, as these species tend to be of the greatest conservation concern yet produce highly variable model outputs. Differences in vulnerability between diverging greenhouse gas concentration scenarios are most readily observed for end‐of‐century time periods and within species' currently occupied habitats (no dispersal).
Metabolic profiling of tryptophan pathways: Implications for obesity and metabolic dysfunction‐associated steatotic liver disease
Authors: Arto Carmen , Rusu Elena Cristina , Clavero‐Mestres Helena , Barrientos‐Riosalido Andrea , Bertran Laia , Mahmoudian Razieh , Aguilar Carmen , Riesco David , Chicote Javier Ugarte , Parada David , Martínez Salomé , Sabench Fàtima , Richart Cristóbal , Auguet Teresa 
Published: June 2024

AbstractBackground and AimsThe rise in obesity highlights the need for improved therapeutic strategies, particularly in addressing metabolic dysfunction‐associated steatotic liver disease (MASLD). We aim to assess the role of tryptophan metabolic pathways in the pathogenesis of obesity and in the different histological stages of MASLD.Materials and MethodsWe used ultra‐high performance liquid chromatography to quantify circulating levels of 15 tryptophan‐related metabolites from the kynurenine, indole and serotonin pathways. A cohort of 76 subjects was analysed, comprising 18 subjects with normal weight and 58 with morbid obesity, these last being subclassified into normal liver (NL), simple steatosis (SS) and metabolic dysfunction‐associated steatohepatitis (MASH). Then, we conducted gene expression analysis of hepatic IDO‐1 and kynyrenine‐3‐monooxygenase (KMO).ResultsKey findings in obesity revealed a distinct metabolic signature characterized by a higher concentration of different kynurenine‐related metabolites, a decrease in indole‐3‐acetic acid and indole‐3‐propionic acid, and an alteration in the serotonin pathway. Elevated tryptophan levels were associated with MASLD presence (37.659 (32.577–39.823) μM of tryptophan in NL subjects; 41.522 (38.803–45.276) μM in patients with MASLD). Overall, pathway fluxes demonstrated an induction of tryptophan catabolism via the serotonin pathway in SS subjects and into the kynurenine pathway in MASH. We found decreased IDO‐1 and KMO hepatic expression in NL compared to SS.ConclusionsWe identified a distinctive metabolic signature in obesity marked by changes in tryptophan catabolic pathways, discernible through altered metabolite profiles. We observed stage‐specific alterations in tryptophan catabolism fluxes in MASLD, highlighting the potential utility of targeting these pathways in therapeutic interventions.
Genetic and epigenetic differentiation in response to genomic selection for avian lay date
Authors: Lindner Melanie , Verhagen Irene , Mateman A. Christa , van Oers Kees , Laine Veronika N. , Visser Marcel E. 
Published: June 2024

AbstractAnthropogenic climate change has led to globally increasing temperatures at an unprecedented pace and, to persist, wild species have to adapt to their changing world. We, however, often fail to derive reliable predictions of species' adaptive potential. Genomic selection represents a powerful tool to investigate the adaptive potential of a species, but constitutes a ‘blind process’ with regard to the underlying genomic architecture of the relevant phenotypes. Here, we used great tit (Parus major) females from a genomic selection experiment for avian lay date to zoom into this blind process. We aimed to identify the genetic variants that responded to genomic selection and epigenetic variants that accompanied this response and, this way, might reflect heritable genetic variation at the epigenetic level. We applied whole genome bisulfite sequencing to blood samples of individual great tit females from the third generation of bidirectional genomic selection lines for early and late lay date. Genomic selection resulted in differences at both the genetic and epigenetic level. Genetic variants that showed signatures of selection were located within genes mostly linked to brain development and functioning, including LOC107203824 (SOX3‐like). SOX3 is a transcription factor that is required for normal hypothalamo‐pituitary axis development and functioning, an essential part of the reproductive axis. As for epigenetic differentiation, the early selection line showed hypomethylation relative to the late selection line. Sites with differential DNA methylation were located in genes important for various biological processes, including gonadal functioning (e.g., MSTN and PIK3CB). Overall, genomic selection for avian lay date provided insights into where within the genome the heritable genetic variation for lay date, on which selection can operate, resides and indicates that some of this variation might be reflected by epigenetic variants.
The price impact of tweets: A high‐frequency study
Authors: Yang Ni , Fernandez‐Perez Adrian , Indriawan Ivan 
Published: June 2024

AbstractWe examine the mechanism by which social media sentiment affects stock prices. Specifically, we assess the impact of Twitter feeds on stock returns at the intraday level. We find that an increase in buyer‐initiated trades has a significantly positive price impact. This impact, however, is stronger with an increase in the number of tweets and sentiment, and persists even after controlling for volatility, liquidity shock, and limit‐order activity. The impact of Twitter sentiment on prices causes a lingering mispricing effect that is not fully assimilated at the intraday level. Rather, this mispricing takes several days to correct.
Controlled experiments fail to capture plant phenological response to chilling temperature
Authors: Wang Huanjiong , Lin Shaozhi , Dai Junhu , Ge Quansheng 
Published: June 2024

AbstractAimControlled experiments are increasingly important for investigating how and to what degree plant phenology responds to global climate change. Current experiments underline that chilling and forcing temperatures are two major environmental cues shaping the budburst date of temperate species, but whether experiments could reflect the observed responses to chilling has rarely been examined.LocationEurope and North America.Time periods1951–2021.Major taxa studiedTemperate trees and shrubs.MethodsUsing an experimental database of budburst dates for 50 species derived from previous literature and observational data of the same species at 12,579 stations in Europe and 1469 stations in the USA, we compared the response of forcing requirement (FR) of the budburst date to chilling accumulation (CA) between observations and experiments using a common measure of FR and CA.ResultsThe median, variance and probability distribution of CA‐FR curves differed significantly between experiments and observations in most cases. The distinction in chilling effects between experiments and observations could be attributed to the difference in thermal space, heat stress, genetic variation among provenances, different forcing treatments adopted and plant materials used in the experiments.Main conclusionsOur results suggest that the uncertainty of phenological models based solely on the experimental data needs to be re‐evaluated when predicting future spring phenological responses across broad spatial scales.
Impact of specialized renal technologists on optimizing delivery of continuous kidney replacement therapy in critical care areas a retrospective study
Authors: Khater Noha Abou , Sadeq Ahmed Adel , Al Absi Dima Tareq , Simsekler Mecit Can Emre , Khattab Islam Mohamed , Shalaby Ehab Aboualazayem , AbuKhater Rawan , Kashiwagi Deanne Tomie , Andras Christian , Molesi Andrea , Omar Fahad , Abbas Mezher , Pirayil Mohammed Sifar , Anwar Siddiq 
Published: June 2024

AbstractBackgroundContinuous renal replacement therapy (CKRT) is delivered to some of the most critically ill patients in hospitals. This therapy is expensive and requires coordination of multidisciplinary teams to ensure the prescribed dose is delivered. With increased demands on the critical care nursing staff and increased complexities of patients admitted to critical care units, we evaluated the role of specialized renal technologists in ensuring the prescribed dose is delivered. Therefore, the aim of this study is to investigate the impact of supporting intensive care unit nurses with specialized renal technologists on optimizing efficiency of CKRT sessions in the United Arab Emirates.MethodsThis is a retrospective study that compared critically ill patients on CKRT overseen by specialized renal technologists versus who are non‐covered in the year 2021.ResultsA total of 331 sessions on 158 patients were included in the study. The mean filter life was longer in specialized renal technologists—covered patients compared to the non‐covered group (66 vs. 59 h, p = 0.019). After adjustment by multiple regression analysis for risk factors (i.e., age, gender, mechanical ventilation, sepsis, mean arterial pressure, vasopressors, and SOFA) that may affect CKRT machines' filter life, presence of a specialized renal technologists resulted in significantly longer filter life (co‐efficient 0.129; CI 95% 1.080, 11.970; p‐value: 0.019).ConclusionOur study suggests that specialized renal technologists play a vital role in prolonging CKRT machine's filter life span and optimizing CKRT machine's efficiency. Further research should focus on other potential benefits of having specialized renal technologists performing CKRT sessions, and to confirm the finding of this study. Additionally, a cost–benefit analysis could be conducted to determine the economic impact of having specialized teams performing CKRT.
Genetic polymorphisms associated with developmental defects of enamel: A systematic review
Authors: Lopes‐Fatturi Aluhê , Fonseca‐Souza Gabriela , Wambier Leticia Maira , Brancher João Armando , Küchler Erika Calvano , Feltrin‐Souza Juliana 
Published: July 2024

AbstractBackgroundPolymorphisms in genes related to enamel formation and mineralization may increase the risk of developmental defects of enamel (DDE).AimTo evaluate the existing literature on genetic polymorphisms associated with DDE.DesignThis systematic review was registered in the PROSPERO (CRD42018115270). The literature search was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library, and in the gray literature. Observational studies assessing the association between DDE and genetic polymorphism were included. The Newcastle–Ottawa Scale was used to assess the risk of bias.ResultsOne thousand one hundred and forty‐six articles were identified, and 28 met the inclusion criteria. Five studies presented a low risk of bias. Ninety‐two genes related to enamel development, craniofacial patterning morphogenesis, immune response, and hormone transcription/reception were included. Molar–incisor hypomineralization (MIH) and/or hypomineralization of primary second molars (HPSM) were associated with 80 polymorphisms of genes responsible for enamel development, immune response, morphogenesis, and xenobiotic detoxication. A significant association was found between the different clinical manifestations of dental fluorosis (DF) with nine polymorphisms of genes responsible for enamel development, craniofacial development, hormonal transcription/reception, and oxidative stress. Hypoplasia was associated with polymorphisms located in intronic regions.ConclusionMIH, HPSM, DF, and hypoplasia reported as having a complex etiology are significantly associated with genetic polymorphisms of several genes.
Family members’ conceptions of their supportive care needs across the colorectal cancer trajectory – A phenomenographic study
Authors: Samuelsson Maria , Jakobsson Jenny , Bengtsson Mariette , Lydrup Marie‐Louise , Wennick Anne 
Published: June 2024

AbstractAimTo describe the variations of family members' conceptions of their supportive care needs (SCN) across the colorectal cancer (CRC) trajectory.DesignA descriptive qualitative study with a phenomenographic approach.MethodIndividual semi‐structured interviews were conducted from May 2022 to October 2022 with 23 family members of persons diagnosed with colorectal cancer. The interviews were analysed using phenomenographic analysis following the Consolidated criteria for reporting qualitative research (COREQ) checklist.ResultsThe phenomenographic analysis resulted in five categories. Not of importance describes family members' needs as unimportant due to the good prognosis and the organization of care and in relation to the needs of others. Only satisfiable by professionals describes information possessed by the healthcare professionals as key, as well as the need for professional counselling for the family members to process their emotions. Managed by themselves describes family members preferring to manage their SCN themselves by turning to the appropriate social support and/or by using coping skills. Understood retrospectively describes SCN as only understandable when things have calmed down and as requiring one's own experience to understand. Left unmet describes SCN as unnoticed by the healthcare professionals or not brought to light by the family members, or family members not knowing where to turn for support.ConclusionSupportive care should involve individualized information, proactive and repeated assessments of needs across the trajectory, as well as encouragement of family members to reflect on their needs and to accept support when needed.ImpactThere is a gap in the literature regarding family members' SCN across the CRC trajectory which this study addresses. Findings show five categories of family members' conceptions of their SCN. Those findings could serve as a basis for the development of clinical colorectal supportive care across the cancer trajectory.Implications for the Profession and/or Patient CareFindings show that to offer family members of persons diagnosed with colorectal cancer support only at the time of diagnosis is insufficient. Instead, the healthcare team is recommended to proactively and repeatedly try to identify those in need and the characteristics of their needs. In addition, it is important to offer individualized information and strive to encourage family members to reflect on their situation and to not suppress their own needs if emerging.Reporting MethodReporting adheres to the consolidated criteria for reporting qualitative research (COREQ) checklist.Patient or Public ContributionNo patient or public contribution.
Organisational culture in ‘better’ group homes for adults with intellectual and developmental disabilities in England: A qualitative study
Authors: Fox Diane , Beadle‐Brown Julie , Bradshaw Jill , Bigby Christine , Richardson Lisa 
Published: June 2024

AbstractBackgroundPrevious research identifies organisational culture as one of a number of factors associated with the quality of life outcomes of group home residents' with intellectual and developmental disabilities. This study aims to elaborate on the dimensions of group home culture in settings in England.MethodParticipant observations and semi‐structured interviews with staff were carried out in two group homes. Field‐notes, interview notes and transcripts were analysed using inductive thematic analysis by a researcher naïve to the project and the previous literature. Initial coding was re‐examined after sensitisation to theorised models in previous literature to identify the most parsimonious fit. The two settings were rated and compared using a five‐point Likert scale for each of the dimensions.ResultsThe findings describe group home culture across seven dimensions. There were mixed ratings across the different dimensions reflecting inconsistencies in culture that were reflected in staff practice. The challenge in assigning a global rating of culture in group homes, which includes interactions across multiple staff and multiple residents over time, was highlighted.ConclusionThe development of an observational measure of culture is highlighted as potentially helpful in understanding and responding to culture in services for individuals with intellectual and developmental disabilities.
Communities of metazoan parasites in seven sympatric skate species (Elasmobranchii, Rajidae) from the English Channel and Celtic Sea differing in conservation status
Authors: Gérard Claudia , Trochard Caroline , Hervé Maxime R. , Hamel Héloïse , Gay Mélanie , Barbier Michel , Trancart Thomas , Barreau Thomas 
Published: June 2024

AbstractElasmobranch populations are in steep decline mainly due to overfishing bycatch, but parasites may accelerate the collapse of vulnerable and/or highly parasitized species. We therefore studied metazoan parasites of Rajidae from the northeast Atlantic: vulnerable Leucoraja fullonica, near‐threatened Raja brachyura, Raja clavata, Raja microocellata and Raja undulata, and least‐concerned Raja montagui and Leucoraja naevus. Overall prevalence varied from 19% for R. montagui to 100% for L. fullonica. Parasite communities differed between skate species, and prevalence and abundance were higher for L. fullonica, R. microocellata, and R. undulata. We recorded 11 parasite taxa in the study: three nematodes, six cestodes, one monogenean, and one myxosporean. Whatever the skate species, the parasite component community comprised at least two nematode taxa among Phocanema spp., Proleptus sp. and Anisakis simplex. DNA‐sequencing revealed that Phocanema azarasi and Phocanema krabbei both occurred in R. microocellata and R. undulata. Phocanema spp. was first recorded in L. fullonica, L. naevus, R. microocellata, R. montagui, and R. undulata, as Proleptus sp. in L. fullonica, and A. simplex in L. fullonica and R. clavata, Rockacestus sp. and Nybelinia sp. in R. undulata, and gill‐myxosporeans on L. fullonica, L. naevus, R. microocellata, and R. undulata. The occurrence of 16 new host–parasite associations suggests potential environmental changes. Information provided by trophically transmitted helminths confirmed an opportunistic skate diet based on crustaceans and fish. We discuss results in terms of host fitness loss, bioindicator role of parasites, and anisakiasis risk. We recommend incorporating parasitology in research to improve elasmobranch conservation.