bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les priapolithes et hysterapetrae de Pierre Borel
Authors: Cavaillé Jean-Pierre 
Published: July 2024

Pierre Borel, collectionneur, savant et polygraphe du xvii
e siècle, décrit dans ses Antiquités de Castres des pierres très remarquables à ses yeux du fait de leur forme phallique. Il les baptise « priapolithes » et s’interroge sur leur engendrement et sur leurs éventuelles vertus médicinales, voire aphrodisiaques. Mais ces pierres apportent surtout pour lui une preuve, parmi tant d’autres, de la vie des pierres, théorie ancienne mise en cause par la jeune science mécaniste. L’article l’accompagne dans sa réflexion et montre comment, jusqu’au xix
e siècle, les priapolithes qui enrichissent les collections des naturalistes sont des objets privilégiés pour spéculer sur la signification – s’il en est une au-delà des « jeux de la nature » – des ressemblances entre certaines pierres et les organes du corps humain, du phénomène même de similitude que l’œil humain rencontre partout dans la nature.
Randomized prospective trial comparing two schedules of hypofractionated adjuvant radiotherapy 3 weeks against 1 week fractionation regimen in females with breast cancer
Authors: Yassin Radwa A. , Mostafa Ehab , Naguib Khaled , Ammar Hany , Moussa Diaa El Din 
Published: July 2024

Purpose
Acceleration of radiotherapy in five fractions for breast cancer can improve treatment accessibility, especially in low, middle-income countries and during pandemics. We report on acute toxicity after whole breast irradiation/chest wall irradiation±nodal irradiation, radiotherapy interruption and reported acute pneumonitis with an ultra-hypofractionation schedule compared to modest hypofractionation protocol during the coronavirus disease pandemic.

Patients and methods
Acute toxicity assessment using the RTOG acute toxicity scoring system. One of two specified doses was administered to the breast: 15 × 2.67 Gy (40.05 Gy) or 5 × 5.2 Gy (26 Gy), tumor boost when indicated prescribed dose 5 × 200 Gy with three-dimensional conformal radiotherapy technique. Inclusion criteria were: T1–T3 invasive breast cancer, N0–N1 and N2 after breast conserving or modified radical surgery.

Results
A total of 101 patients were included in the study. Median age was 53 ± 10.29 years, with median follow-up time 14 months (12–20 months). A significant difference was observed for acute skin toxicity after radiotherapy in favor of better tolerability for the ultrafractionation schedule (P<0.0001). None of the cases in ultra-hypofractionation had interrupted radiotherapy course for more than 2 days, on the other hand, 45.8% of the cases in modest hypofractionation had interrupted course with chest infection as the second most common cause. Regarding acute radiation pneumonitis none of the cases in both arms reported grades 3–4 acute radiation pneumonitis within the first 90 days postradiotherapy.

Conclusion
Regarding initial toxicity and patient adherence to the radiation course, this single institute study suggests that hypofractionated breast irradiation in 15 fractions compares favorably to accelerated breast radiotherapy in five fractions over 5 days. However, a longer time for follow-up and larger enrolled numbers are needed to confirm noninferiority of this approach.
Comparative evaluation of baseline SOFA score and CURB-65 score in predicting patient severity and outcome in COVID-19 patients admitted to a tertiary care ICU
Authors: Vineet Anvita , Choudhury Arin , Krishna Bhavya , Kohli Santvana , Kumar Arun 
Published: July 2024

IntroductionCOVID-19 is primarily a pulmonary disease, but with significant and frequent systemic manifestations. Our study aims to assess, which scoring system on admission—Confusion, Uraemia, Respiratory Rate > 30/min, Blood Pressure low, Age > 65 years (CURB-65) or SOFA, better correlates with COVID-19-positive patient mortality.MethodologyThis prospective observational study was conducted in COVID-positive adult patients. Upon admission, patient demographics, clinical condition and laboratory investigations were noted. SOFA and CURB-65 scores were calculated for each patient and the patient was followed up till the final outcome—transfer or expiry.ResultsOut of the 100 patients included in our study, the majority belonged to the age group of 41–60 years, with a mean age of 51 years. A significant proportion of patients (83%) had at least 1 pre-existing co-morbidity. The absence of co-morbidity showed an association with improved survival. The overall mortality rate was 46%. Baseline SOFA and CURB-65 scores showed a correlation with patient outcome, but SOFA showed a greater strength of association. It was found that at a cut-off of a total SOFA score of ≥4, it predicts patient expiry with a sensitivity of 89% and a specificity of 72%.DiscussionCURB-65 is a scoring system used for severity assessment, guide therapy and prognostication of patients with lower respiratory tract infection or pneumonia. SOFA, on the other hand, is an ICU score used in multi-system diseases used for evaluating disease progression and prognostication. Many authors have found that SOFA score correlates well with patient outcome, and a high SOFA on admission usually indicates poor prognosis.
ECG abnormalities in chronic obstructive pulmonary disease exacerbation: can the ECG record still astound us? A prospective study
Authors: Biljana Lazovic , Ivan Zivotic , Radmila Dmitrovic , Nevena Jovičić , Isidora Simonovic , Rade Milic , Sanja Sarac 
Published: July 2024

Introduction/objective
Chronic obstructive pulmonary disease (COPD) is a pulmonary disease characterized by persistent respiratory difficulties and impaired airflow. COPD patients have a higher risk for lung infections, like the flu or pneumonia, lung cancer, heart problems, weak muscles, brittle bones, depression, and anxiety.
The purpose of this study was to estimate the prevalence of ECG abnormalities in patients with COPD experiencing exacerbations.

Patients and methods
The research encompassed a cohort of 832 individuals diagnosed with COPD who encountered episodes of exacerbations. Five hundred seventy-five (69.11%) of the included participants were women, and 257 (30.89%) were men. The included participants ranged from 18 to 60 years old. It was ensured that none of the participants had received any treatment for their condition for more than 3 days.

Results
Based on the level of exacerbation severity, the patient population is categorized into three distinct groups: moderate, comprising 330 (39.66%) individuals; severe, encompassing 406 (48.79%) individuals; and extremely severe, consisting of 96 (11.53%) individuals. During episodes of exacerbation in patients with COPD, the following ECG alterations were observed: a QTc less than 0.40 s in 99.15% of cases, a transitional ECG zone in 74.33% of cases, a P more than 2.5 mm in 45.67% of cases, an axis deviation towards the second quadrant (axis II) in 28% of cases, an incomplete right bundle branch block in 26.32% of cases, and a full right bundle branch block in 25.60% of cases.

Conclusion
Regardless of prior cardiac pathology, ECG is a low-cost, quick, and dependable modality for detecting ischemic changes in people experiencing a flare-up of COPD.
Post-COVID syndrome: Clinical pattern and impact on health related quality of life
Authors: Mohamed Ashraf Zin EL-Abdeen , Shaaban Lamiaa Hassan , Attia Mostafa Mahmoud , Khaleel Waleed Gamal Elddin 
Published: July 2024

Background
COVID-19 management has changed from just dealing with a novel respiratory viral illness to unraveling the mystery of a systemic disease. This study aimed to assess clinical pattern for post-COVID survivors and impact on quality of life.

Methods
115 Patients suffering from COVID-19 affection were recruited in this study. The assessment included clinical history with special attention to symptoms attributable to post-COVID manifestations. Evaluation for presence of insomnia, anxiety and depression were done using insomnia severity index (ISI), Hamilton’s anxiety (HAM-A) and depression rating scales (HAM-D), respectively. Laboratory investigations included complete blood count (CBC), kidney function test, liver function test, C-reactive protein (CRP), and inflammatory markers including ESR, CRP and Ferritin level. EQ-5D-5L and EQ visual analogue scale (EQ-VAS) were used to assess participants’ overall health status and quality of life.

Results
COVID-19 patients suffered from cough (76%), fever (72.9%), fatigue (72.9%), dyspnea (69.8%) and muscle/joint pain (66.1%) as the most distressing symptoms during period of acute infection. Regarding post-COVID syndrome (PCS); Dyspnea (32.2%), fatigue (26.1%), muscle/joint pain (22.6%), loss of taste (16.5%) and loss of smell (15.7%) were the most prevalent at 3 month evaluation. 46.9% patients developed manifestations attributable to post-COVID syndrome. Fever, cough, loss of smell and taste, fatigue, anxiety and insomnia persisted significantly for longer periods among severe cases (Group 2). EQ-5D-5L domains were significantly impaired among severe COVID patients. Significant positive correlation noticed between age and increased duration of dyspnea, muscle/joint pains and depression. Also, CT chest severity scores showed significant correlation with dyspnea, fatigue, muscle/joint pains (P=0.023, 0.012 and <0.001; respectively).

Conclusion
High prevalence of Post-COVID syndrome is a challenge to health care resources. PCS directly impacts mobility, self-care, usual activities, pain perception and anxiety and therefore is associated with lower quality of life among post-COVID patients.
Investigation of recurrence of joint symptoms after COVID-19 in patients with rheumatoid arthritis: Cross-sectional study
Authors: Akbarpour Afsaneh , Salesi Mansour , Babak Anahita 
Published: July 2024

Abstract

Background:
In this study, the relationship between involvement by COVID-19 and the recurrence of symptoms of rheumatoid arthritis (RA) was investigated.

Materials and Methods:
This cross-sectional study was conducted on 112 patients with RA with and without a history of COVID-19. The severity and recurrence of RA symptoms were measured and recorded by the Disease Activity Score in 28 joints (DAS-28) index and clinical evaluations by a rheumatologist.

Results:
The results showed that the recurrence of RA in patients with and without a history of COVID-19 had a statistically significant difference (P < 0.001). In addition, there was a statistically significant relationship between erythrocyte sedimentation rate, visual analogue scale (VAS), tender joint count, swollen joint count, and DAS-28 and the history of COVID-19 (P < 0.05).

Conclusion:
The present study showed that infection with COVID-19 leads to the recurrence of joint symptoms in RA patients.
Efficacy and safety of quick penetrating solution heparin, quick penetrating solution diclofenac, and heparin gel in the prevention of infusion-associated superficial thrombophlebitis: A randomized controlled trial
Authors: Bajpai Vijeta , Patel Tejas K. , Dwivedi Priyanka , Kabi Ankita , Singh Yashpal , Agarwal Richa , Gupta Ravi , Kishore Surekha 
Published: July 2024

Abstract

Background:
The present study aimed to compare the efficacy, safety, and cost-effectiveness of quick penetrating solution (QPS) heparin, QPS diclofenac, and heparin gel in the prevention of superficial thrombophlebitis (ST).

Materials and Methods:
This randomized controlled trial was conducted after approval from the Institutional Ethics Committee and registration to Clinical Trial Registry of India. Patients of 18–60 years age, American Society of Anesthesiologists I/II, and who needed venous cannulation for at least 72 h were included in the study. Patients were randomly divided into three groups receiving study drugs (heparin gel, QPS heparin, and QPS diclofenac) every 8 hourly for a period of 72 h. Venous cannulation site was graded using the Visual Infusion Phlebitis Scale. Patients developing no ST, mean time to reach ST Grade 1 and 2, prevention of ST probability, and cost-effectiveness of interventions during the study period were assessed.

Results:
Out of 219 included patients, development of no ST in the study groups at 72 h of treatment were heparin gel (11%), QPS heparin (9.6%), and QPS diclofenac (2.7%). The mean time (hours) to develop any grade ST in the study arms was heparin gel (36.2 [11.9]), QPS heparin (40.0 [13.4]), and QPS diclofenac (37.0 [13.2]). The Kaplan–Meier analysis did not reveal significant differences for the prevention of any grade ST or severe ST in three treatment arms. The average cost-effectiveness ratio for preventing thrombophlebitis was 14.2 in heparin gel-, 13.2 in QPS heparin-, and 95.6 in QPS diclofenac-treated patients.

Conclusion:
Based on efficacy, safety, and cost-effectiveness, heparin gel or QPS heparin can be used to prevent ST due to intravenous cannulation in surgical patients. QPS diclofenac is not a cost-effective option to prevent ST.
Impact of cytoreductive surgery with and without chemoradiation on the outcome of induced oral squamous cell carcinoma: an experimental study
Authors: Amr Nouran Mouhammed Ahmed , Salem Mohamed Labib , Shoushan Mohamad M. , AbouZaid Basant H. 
Published: July 2024

Objectives
The aim of this study is to evaluate the effect of cytoreductive surgery with and without chemoradiation on tumor size, survival rate and systemic status in hamsters with chemically induced oral squamous cell carcinoma (OSCC).

Design
The study was conducted on eighty-eight male hamsters. OSCC was induced by 7,12-Dimethylbenz[a] anthracene (DMBA) painted on hamsters’ buccal pouch. Hamsters were subsequently divided into four groups, group 1 (n = 22) employed as control group, group 2 (n = 22) with only induced OSCC left without treatment, group 3 (n = 22) underwent surgical removal of 75% of tumor mass, and group 4 (n = 22) underwent surgical procedures combined with chemoradiation.

Results
Clinical evaluation revealed that cytoreductive surgery combined with chemoradiation was associated with overall tumor size reduction and improvement of survival rate. Histological examination revealed necrosis of tumor tissue and heavy infiltration by chronic inflammatory cells were also observed.

Conclusion
Chemoradioation therapy after debulking surgery was associated with a decrease of tumor size and improvement in survival rate.
Comparative evaluation of dental integrity using three computer-aided design/computer-aided manufacturing customized post systems
Authors: Ghalleb Mohammed A. , El-Dessouky Radwa A. , Massoud Gaber I. 
Published: July 2024

Background
Endodontically treated teeth (ETT) are considered structurally compromised due to significant changes in their biomechanics.The purpose of this in vitro study was to evaluate fracture resistance using three computer-aided design/computer-aided manufacturing (CAD/CAM) customized post systems.

Methods
Forty extracted intact maxillary central incisors were used in the study, and the teeth were endodontically treated and randomly divided into four equal groups (n = 10): control group without any post and accessed cavity was restored with direct composite restoration. Test groups were prepared for a post and restored according to the material type. The posts and cores were fabricated with computer-aided design/computer-aided manufacturing technology using titanium, vita enamic, and biological dentin materials. The posts were luted using self-adhesive resin cement, and then, zirconia crowns were fabricated, cemented, teeth in all groups were mounted to universal testing machine and subjected to compressive load in Newton at crosshead speed 0.5 mm/min.

Results
Control group exhibited the highest fracture resistance (727 ± 172.05) followed by biological dentin posts with mean value (712.29 ± 298.58) then group titanium posts with mean value (678.59 ± 132.83) and the least fracture resistance was for group vita enamic with mean value 331.84 ± 74.27. Regarding to fracture favorable it was significantly higher in vita post group than titanium post group (70% vs. 30%) and control group (70% vs. 10%) but it was significantly higher in biological dentin group than titanium group (80% vs. 70%).

Conclusion
According to type of material, teeth restored with the biological dentin posts showed highest fracture resistance followed by titanium posts, the least fracture resistance was vita enami posts.
Antioxidant, Antidiabetic, and Antibacterial Activities of Terminalia bellerica Seed Extracts in Various Solvent Polarities
Authors: Atmira Sariwati  , Fita Sari  , Venty Suryanti  , Desi Suci Handayani  , Ichiro Kamei  , Ninis Yuliati  
Published: July 2024

Terminalia bellerica is well-known for producing edible fruits with pharmacotherapeutic properties. Traditional healers use these species to treat and control diabetes mellitus, its side effects, and other illnesses. Involved in this disease's pathophysiological process, extensive research has been conducted to validate and comprehend these bioactive claims scientifically. This research aims to ascertain the bioactive metabolite contents of different solvent polarities, including ethyl acetate, hexane, distilled water, and methanol. The phenol concentration was determined using the Follin-Ciocalteu procedure to be between 23.45 and 160.41 mg GAE/g. The aluminum chloride colorimetric technique measured flavonoid concentration from 88.52 to 7.12 mg QE/g. The quantitative values of tannic acid, which spanned from 0.78 to 5.32 mg TAE/g, were determined by spectrophotometry UV-VIS. The extracts' capacity to reduce free radical damage ABTS (2, 2' azinobis (3-ethylbenzene-thiazoline-6-sulfonic-acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) was examined. The extract ethyl acetate exhibited the most significant level of antioxidant activity, with IC50 values for DPPH and ABTS of 28.17 and 22.22 g/ml, respectively. Staphylococcus aureus (23 mm) and were tested for antibacterial and antifungal activity in a methanol extract (21 mm). In vitro, antidiabetic activities were assessed using α-glucoside and α-amylase inhibition. The ethyl acetate extract has α-glucoside inhibition IC50 of 23.04 g/ml and α-amylase inhibition IC50 of 25.35 g/ml. T. bellerica seed includes secondary metabolites that show promise as lead chemicals in creating potent medications.
PEMBELAJARAN AKIDAH MELALUI KAJIAN INTERAKTIF BERBASIS MULTIMEDIA
Authors: Wibowo Irham 
Published: July 2024

Not a few Muslims and Muslim women still go to shamans to ask for help and it is a sad thing that Islam with its noble and rational teachings has negated things that are irrational. Therefore, in collaboration with Radio EMC 97.8 FMPuspita Radja Yogyakarta, the ‘Mutiara Ramadhan 1445 Hijriyah’ activity was held. The big theme raised is related to the faith chapter, while the sub-theme of the discussion outlined is related to magic and shamanism. Through radio media and other supporting multimedia devices such as YouTube live streaming, it is hoped that the target segmentation, apart from parents, is the younger generation. The methods used are lectures and interactive dialogue (question and answer). The audience in this activity found it very useful because it helped them increase their understanding of religion, especially the pure Islamic faith.Keywords: Islamic creed; Multimedia Studies; Da'wah.
Penerapan Model Pailkem Dan Teknik Teratai Untuk Meningkatkan Kemampuan Menulis Naskah Drama Pada Siswa Kelas XI Sosial IV SMA YPPK Taruna Bakti Waena.
Authors: Ayu Marshinta Wulandari Putri , Yani Juli , Marzuki Ismail 
Published: July 2024

Pembelajaran bahasa dikenal adanya empat komponen keterampilan berbahasa, yaitu keterampilan menyimak, berbicara, membaca, dan menulis. Keempat komponen ini memiliki saling keterkaitan antara satu dan lainnya dan tidak dapat dipisahkan. Kemampuan menulis memberikan makna yang penting untuk berkomunikasi secara tidak langsung dalam kehidupan sehari-hari. Untuk meningkatkan kemampuan menulis, dalam penelitan ini digunakan tenik Teratai dengan model Pailkem. Melihat kemampuan menulis siswa kelas XI Sosial 4 SMA YPPK Taruna Bakti masih tergolong rendah, maka penelitian ini sangat perlu untuk dilakukan. Permasalahan yang terungkap adalah siswa belum berani tampil mengeluarkan ide-ide yang dimilikinya dalam menulis naskah drama. Penelitian ini merupakan penelitian tindakan kelas. Tindakan yang dilakukan dalam penelitian ini meliputi tiga siklus. Tiap siklus dilakukan secara bertahap yang terdiri dari empat tahap yaitu, (1) perencanaan, (2) tindakan, pengamatan (observasi) dan, (4) refleksi. Subjek penelitian ini adalah siswa kelas XI Sosial IV SMA YPPK Taruna Bakti. Data penelitian diambil dengan tes dan nontes. Pengambilan data melalui tes yaitu paktek menulis naskah drama, sedangkan pengambilan data melalui nontes berupa lembar observasi dan dokumentasi. Berdasarkan penelitian, pembelajaran kemampuan menulis siswa menggunakan teknik Teratai dan Pailkem, mengalami peningkatan bila dibandingkan dengan hasil belajar siswa pada penelitian awal prasiklus yang hanya mencapai 66,12%. Pada siklus I peningkatan kemampuan menulis siswa mencapai 71,70%, dan siklus II tingkat kemampuan menulis naskah drama 81, 03%. Dengan demikian, dapat disimpulkan tingkat kemampuan menlis naskah drama siswa mengalami peningkatan setelah menggunakan teknik Teratai dan model Pailkem
Studi Manajemen Proyek Pembangunan Main Dam pada Bendungan Bulango Ulu dengan Metode Fasttrack dan Crashing
Authors: Renate Simanungkalit Eliana , Tri Juwono Pitojo , Nur Cahya Evi 
Published: July 2024

Pembangunan Bendungan Bulango Ulu yang terletak di Sungai Mongiilo, Desa Tuloa, Kecamatan Bulango Utara, Kabupaten Bone Bolango, Provinsi Gorontalo merupakan salah satu upaya penanganan yang dilakukan pemerintah daerah untuk mengatasi permasalahan banjir di Provinsi Gorontalo. Proyek pembangunan Main Dam pada Bendungan Bulango Ulu merupakan proyek perekayasaan yang berskala besar. Pada proyek pembangunannya banyak aktivitas, biaya, sumber daya dan instansi maupun individu yang terlibat di dalamnya, untuk itu diperlukan penjadwalan proyek yang baik. Sampai saat ini pelaksanaan pembangunan Bendungan Bulango Ulu masih dalam tahap pelaksanaan. Diperlukan adanya suatu metode pengaturan untuk mengkoordinasikan kegiatan, sumber daya, dan pihak-pihak yang terlibat di dalamnya, agar proyek dapat mencapai waktu, biaya dan kualitas secara optimal. Tujuan dari penelitian ini adalah untuk menghasilkan alternatif penjadwalan yang lebih baik serta pengelolaan proyek secara menyeluruh termasuk manajemen sumber daya dan durasi kerja. Alternatif yang dilakukan pada studi ini adalah Fasttrack dan Crashing penambahan jam lembur. Hasil yang didapatkan berupa kurva S, waktu dan jumlah kebutuhan sumber daya yang akan dievaluasi kembali serta dipilih alternatif mana yang paling optimal. Berdasarkan hasil optimasi menggunakan alternatif Fasttrack didapat efektivitas durasi sebesar 6,9% dengan efisiensi biaya 0,21% dari biaya kontrak, sedangkan dengan alternatif Crashing penambahan jam lembur didapat efektivitas durasi 3,6% dengan efisiensi biaya 2,46% dari biaya kontrak
ҚОРАҚАЛПОҚ ТУКСИЗ ГИЛАМЛАРИНИНГ ТИПОЛОГИЯСИ (ҚОРАҚАЛПОГИСТОН РЕСПУБЛИКАСИ ТАРИХИ ВА МАДАНИЯТИ ДАВЛАТ МУЗЕЙИ АСОСИДА)
Authors: Науризбаева Нуржамал 
Published: July 2024

Ҳар бир халқ, миллат ўз урф-одатлари, эътиқодлари ва маданияти билан ажралиб туради. Бу қорақалпоқ гиламларига ҳам таъсир қилди. Қорақаолпақ туксиз гиламларнинг бошқа халқлардан ажралиб туриши ва ишланиш техникалари озгачалиги билан инсонларга эстетик жиҳаттан таъсир қилиб қоймасдан, безаш услублари ва нақшлари теранг мазмунга эга.