bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Gaussian error distribution of 7Li abundance measurements
Authors: Crandall Sara , Houston Stephen , Ratra Bharat 
Published: July 2015

We construct the error distribution of [Formula: see text] abundance measurements for 66 observations (with error bars) used by Spite et al. (2012) that give [Formula: see text] (median and [Formula: see text] symmetrized error). This error distribution is somewhat non-Gaussian, with larger probability in the tails than is predicted by a Gaussian distribution. The 95.4% confidence limits are [Formula: see text] in terms of the quoted errors. We fit the data to four commonly used distributions: Gaussian, Cauchy, Student’s t and double exponential with the center of the distribution found with both weighted mean and median statistics. It is reasonably well described by a widened [Formula: see text] Student’s t distribution. Assuming Gaussianity, the observed A(Li) is [Formula: see text] away from that expected from standard Big Bang Nucleosynthesis (BBN) given the Planck observations. Accounting for the non-Gaussianity of the observed A(Li) error distribution reduces the discrepancy to [Formula: see text], which is still significant.
Learning without Concentration
Authors: Mendelson Shahar 
Published: July 2015

We obtain sharp bounds on the estimation error of the Empirical Risk Minimization procedure, performed in a convex class and with respect to the squared loss, without assuming that class members and the target are bounded functions or have rapidly decaying tails.
Rather than resorting to a concentration-based argument, the method used here relies on a “small-ball” assumption and thus holds for classes consisting of heavy-tailed functions and for heavy-tailed targets.
The resulting estimates scale correctly with the “noise level” of the problem, and when applied to the classical, bounded scenario, always improve the known bounds.
Why Does Aerosol Forcing Control Historical Global-Mean Surface Temperature Change in CMIP5 Models?
Authors: Rotstayn Leon D. , Collier Mark A. , Shindell Drew T. , Boucher Olivier 
Published: July 2015

Abstract
Linear regression is used to examine the relationship between simulated changes in historical global-mean surface temperature (GMST) and global-mean aerosol effective radiative forcing (ERF) in 14 climate models from CMIP5. The models have global-mean aerosol ERF that ranges from −0.35 to −1.60 W m−2 for 2000 relative to 1850. It is shown that aerosol ERF is the dominant factor that determines intermodel variations in simulated GMST change: correlations between aerosol ERF and simulated changes in GMST exceed 0.9 for linear trends in GMST over all periods that begin between 1860 and 1950 and end between 1995 and 2005. Comparison of modeled and observed GMST trends for these time periods gives an inferred global-mean aerosol ERF of −0.92 W m−2.
On average, transient climate sensitivity is roughly 40% larger with respect to historical forcing from aerosols than well-mixed greenhouse gases. This enhanced sensitivity explains the dominant effect of aerosol forcing on simulated changes in GMST: it is estimated that 85% of the intermodel variance of simulated GMST change is explained by variations in aerosol ERF, but without the enhanced sensitivity less than half would be explained. Physically, the enhanced sensitivity is caused by a combination of 1) the larger concentration of aerosol forcing in the midlatitudes of the Northern Hemisphere, where positive feedbacks are stronger and transient warming is faster than in the Southern Hemisphere, and 2) the time evolution of aerosol forcing, which levels out earlier than forcing from well-mixed greenhouse gases.
Interactome analysis brings splicing into focus
Authors: Dominguez Daniel , Burge Christopher B. 
Published: July 2015

AbstractThe spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing.Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract
Rheumatoid arthritis–associated autoantibodies in non–rheumatoid arthritis patients with mucosal inflammation: a case–control study
Authors: Janssen Koen M J , de Smit Menke J , Brouwer Elisabeth , de Kok Fenne A C , Kraan Jan , Altenburg Josje , Verheul Marije K , Trouw Leendert A , van Winkelhoff Arie Jan , Vissink Arjan , Westra Johanna 
Published: July 2015

Abstract
Introduction
Rheumatoid arthritis–associated autoantibodies (RA-AAB) can be present in serum years before clinical onset of rheumatoid arthritis (RA). It has been hypothesized that initiation of RA-AAB generation occurs at inflamed mucosal surfaces, such as in the oral cavity or lungs. The aim of this study was to assess systemic presence of RA-AAB in patients without RA who had oral or lung mucosal inflammation.

Methods
The presence of RA-AAB (immunoglobulin A [IgA] and IgG anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2), IgM and IgA rheumatoid factor (RF), IgG anti-carbamylated protein antibodies and IgG and IgA anti-citrullinated peptide antibodies against fibrinogen, vimentin and enolase) were determined in sera of non-RA patients with periodontitis (PD, n = 114), bronchiectasis (BR, n = 80) or cystic fibrosis (CF, n = 41). Serum RA-AAB levels were compared with those of periodontally healthy controls (n = 36). Patients with established RA (n = 86) served as a reference group. Association of the diseases with RA-AAB seropositivity was assessed with a logistic regression model, adjusted for age, sex and smoking.

Results
Logistic regression analysis revealed that IgG anti-CCP seropositivity was associated with BR and RA, whereas the association with PD was borderline significant. IgA anti-CCP seropositivity was associated with CF and RA. IgM RF seropositivity was associated with RA, whereas the association with BR was borderline significant. IgA RF seropositivity was associated with CF and RA. Apart from an influence of smoking on IgA RF in patients with RA, there was no influence of age, sex or smoking on the association of RA-AAB seropositivity with the diseases. Anti-CarP levels were increased only in patients with RA. The same held for IgG reactivity against all investigated citrullinated peptides.

Conclusion
Although overall levels were low, RA-AAB seropositivity was associated with lung mucosal inflammation (BR and CF) and may be associated with oral mucosal inflammation (PD). To further determine whether mucosal inflammation functions as a site for induction of RA-AAB and precedes RA, longitudinal studies are necessary in which RA-AAB of specifically the IgA isotype should be assessed in inflamed mucosal tissues and/or in their inflammatory exudates.
A differentiable characterization of local contractions on Banach spaces
Authors: Hefti Andreas 
Published: July 2015

AbstractThis note provides a differentiable characterization of local contractions on an arbitrary Banach space. As a corollary, a refinement to Ostrowski’s sufficient condition for local convergence in finite spaces is obtained, which applies to many models, e.g. in economics, ecology or game theory, where one has an interest in fixed point iterations and local stability of discrete dynamic processes. We show that for the local contraction property to hold, continuity of the derivative at the fixed point is indispensable.
Structural holes, knowledge intermediaries and evolution of the triple helix system with reference to the hard disk drive industry in Thailand
Authors: Nakwa Karantarat , Zawdie Girma 
Published: July 2015

Abstract
This article explores the evolutionary process underlying the development of the triple helix innovation system and the role of knowledge intermediaries in the process. It draws on the experience of knowledge network development in an SME cluster in the Thai hard disk drive industry. Conceptually, the evolutionary process starts with inter-firm networks, which occur in the form of supply chain-based vertical links and trade association or cluster-based horizontal links. These evolve into triple helix networks and culminate into the triple helix innovation system through the agency of network dynamics. Intermediaries enhance network development as sponsors, providing funds; as brokers, closing and bridging structural holes that disconnect network players; and as boundary spanners, facilitating knowledge circulation. The case study suggests that knowledge network development in Thailand has a long way to go before morphing into the triple helix innovation system. Some evidence of network dynamics was nonetheless detected; but for lack of trust in the triple helix culture the fledgling network dynamics fizzled out when the government prop, which initiated the process, was withdrawn. The article concludes by highlighting the need for policy to promote the culture of trust among network players and for knowledge intermediaries to be robustly systemic in their organization and operation.
Normative Characterization in Empirical Explanation
Authors: Bauer Mark 
Published: July 2015

Normative characterization is a commonplace feature of biological and cognitive explanation. Such language seems to commit the biological and cognitive sciences to the existence of natural norms, but it is also difficult to understand how such normativity fits into a natural world of physical causes and forces. Existing models for how such language can have a legitimate causal-explanatory role in the sciences are, I think, unsatisfactory. I suggest an alternative model in which normativity is mapped onto systems stabilized by counteractive constraints. Such a mapping, I propose, explains normativity’s causal-explanatory role in biological and cognitive inquiry.
The Dynamics of Biochemical Parameters in Blood of Clinically Healthy Holstein Cows from Day 5 before to Day 60 after Calving
Authors: Celeska Irena , Janevski Aleksandar , Dzadzovski Igor , Ulchar Igor , Kirovski Danijela 
Published: July 2015

Abstract
The peripartal period in Holstein dairy cows is critical, due to the transition from pregnancy to lactation. We have studied the dynamics of biochemical parameters from day 5 before to day 60 after calving. The study included 10 multiparous Holstein cows, examined at days -5, 5, 10, 30 and 60 relative to calving. Blood samples were taken from vena jugularis. Analyzed biochemical parameters were glucose, triglycerides, total cholesterol, total bilirubin, albumin, total protein, urea, NEFA and BHBA. Milk production and body condition score were also estimated. Obtained results showed that cows were exposed to mild to marked metabolic distress. Energy status was changed due to increased values of NEFA and BHBA and decreased value of glucose after calving. Protein concentrations were increased at day 10 after calving, despite the decrease of the level of albumin. Urea concentrations before and after calving were within physiological range indicating an optimal protein diet. Increased values of total bilirubin at day 5 after calving indicated liver increased activity. Lipid status presented by triglycerides and total cholesterol revealed no differences in blood concentrations. Milk production was highest at day 30 after calving. BCS were highest in dry cows, thereafter they declined and recovered at day 60 after calving.
In conclusion, biochemical parameters can be used as relevant indicators of metabolic distress in cows around calving with milk and BCS recording as aside parameters. Changes in some biochemical parameters indicate liver increased activity and metabolic stress, that could lead to decreased milk production, impaired reproductive performance and, finally, to illness.
Magnetic nanoparticles adapted for specific biomedical applications
Authors: Dutz Silvio , Müller Robert , Eberbeck Dietmar , Hilger Ingrid , Zeisberger Matthias 
Published: July 2015

AbstractMagnetic nanoparticles (MNPs) are used in different biomedical applications, whereby each application requires specific particle properties. To fulfill these requirements, particle properties have to be optimized by means of variation of crystal structure, particle size, and size distribution. To this aim, improved aqueous precipitation procedures for magnetic iron oxide nanoparticle synthesis were developed. One procedure focused on the cyclic growth of MNPs without nucleation of new particle cores during precipitation. The second novel particle type are magnetic multicore nanoparticles, which consist of single cores of approximately 10 nm forming dense clusters in the size range from 40 to 80 nm. Their highest potential features these multicore particles in hyperthermia application. In our
First reports of the red alga Hypoglossum caloglossoides from the Mediterranean and the Red Sea
Authors: Hoffman Razy , Wynne Michael J. 
Published: July 2015

Abstract
The occurrence of the red algal species Hypoglossum caloglossoides (Delesseriaceae, Ceramiales) is reported for the first time from shallow sub-littoral sites in both the Mediterranean Sea and the Red Sea. This small but morphologically distinctive species, originally described from Lord Howe Island in the southwestern South Pacific Ocean, has been recorded from scattered tropical and subtropical locations around the globe. Some aspects of its ecology in the north Israeli Mediterranean are also discussed.
Sequence analysis of minor protein genes of equine arteritis virus during persistent infection
Authors: Rola Jerzy , Socha Wojciech , Żmudziński Jan F. 
Published: July 2015

Abstract
The variability of the ORF2a, ORF2b, ORF3, and ORF4 genes of the equine arteritis virus (EAV) was analysed during a seven year observation of persistent infection in a stallion of the Malopolska breed. A total of 11 semen samples were collected between 2004 and 2011. RNA of EAV isolates obtained from the semen of the stallion was amplified, sequenced, and compared with the sequences of other strains available in GenBank. Multiple nucleotide substitutions were found in sequences of the analysed regions, however, neither deletion nor insertions were detected. The highest number of point mutations (11-6 synonymous and 5 non-synonymous) were found in the ORF2b gene, and the lowest number of substitutions (6-5 synonymous and one non-synonymous) were found in the ORF2a gene. None of the identified mutations affected any of the glycosylation or phosphorylation sites of the minor EAV protein. Phylogenetic analysis of the ORF3 gene of EAV isolates showed that they grouped together within the cluster of European strains of EAV. Additionally, the ORF3 gene sequences of the isolates showed high (86.4% - 98.3%) similarity to the previously isolated Polish EAV strains.
Occurrence and characterisation of MRSA and extended-spectrum ß-lactamases producing Escherichia coli isolated from mastitic cows’ milk
Authors: Weiner Marcin , Różańska Hanna , Kubajka Maria , Szulowski Krzysztof , Krajewska Monika , Wasiński Bernard 
Published: July 2015

Abstract
The aim of study was the preliminary evaluation of the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) and extended spectrum ß-lactamases (ESBL) - producing Escherichia coli in 650 milk and inflammatory secretions from cows with clinical or subclinical mastitis. One millilitre of the sample was added to Mueller-Hinton broth supplemented with 6.5% NaCl, Tryptone Soya Broth with cefoxitin and aztreonam, and then to MRSA ID agar. Presumptive MRSA colonies were analysed for the presence of mecA gene. Parallel to MRSA identification, the samples were incubated in buffered peptone water, lauryl tryptose broth and McConkey agar supplemented with cefotaxim for ESBL-producing E. coli isolation. These bacteria were identified using API Rapid 32 E and the ability of ESBL production was initially established using disc test D68C and confirmed by MIC technique using Sensititre ESBL plates. The primers (blaCTX, blaTEM, blaSHV, and blaCMY-2-group) for the detection of some of the genes encoding ESBL production were used. The 45 strains of S. aureus with mecA gene and 41 strains of E. coli with blaTEM gene were detected.
Dynamics of Echinococcus multilocularis infection in red fox populations with high and low prevalence of this parasite in Poland (2007–2014)
Authors: Karamon Jacek , Kochanowski Maciej , Dąbrowska Joanna , Sroka Jacek , Różycki Mirosław , Bilska-Zając Ewa , Cencek Tomasz 
Published: July 2015

Abstract
The aim of the study was to estimate the current prevalence of E. multilocularis in selected populations of red foxes in Poland and to evaluate the changes in prevalence of this parasite by comparison with the results obtained in the same area during earlier surveillance. The investigations were performed in the area of four Polish provinces: 2 eastern/south-eastern (Lubelskie and Podkarpackie) and 2 south-western (Śląskie and Opolskie). Five hundred red foxes coming from the investigated areas were examined between 2013 and 2014 to estimate the current situation in selected provinces. Moreover, 550 red foxes from the same areas examined between 2007 and 2013 were used for comparison of differences in E. multilocularis prevalences in time. Intestines were examined with the use of the sedimentation and counting technique. Among 500 foxes examined in the current study, 118 were positive for E. multilocularis. There were differences in prevalence between individual provinces: Podkarpackie Province - 54.6%, Lubelskie Province - 18.9%, Śląskie Province - 11.7%, and Opolskie Province - 3.9%. Statistical analysis demonstrated that in most cases there were no differences in prevalence between the current results and the results from previous studies. Only in Opolskie Province was a statistically significant increase observed between 2010 and 2014. A stable degree of infection in the region with high prevalence of this parasite was demonstrated. However, a significant increase in the region with very low prevalence of E. multilocularis points out the necessity to monitor this infection during the coming years to control the progress of the disease
Identification of strains with phenotypes similar to those of Staphylococcus aureus isolated from table chicken eggs using MALDI-TOF MS and genotyping methods
Authors: Marek Agnieszka , Pyzik Ewelina , Stępień-Pyśniak Dagmara , Hauschild Tomasz , Banach Tomasz 
Published: July 2015

Abstract
The aim of the study was to identify the affinity of 10 Staphylococcus strains isolated from table chicken eggs to specific species. Preliminary analysis performed by API ID32 Staph test identified these strains as S. aureus, but they exhibited a negative reaction in the tube coagulase test. Thus, the analysed strains were initially characterised as Staphylococcus aureus-like (SAL). Further characterisation was performed by genotypic methods, using restriction fragment length polymorphism (RFLP) of the coagulase gene (coa) and sequencing of the gene rpoB. An attempt was also made to identify the isolated Staphylococcus strains by MALDI-TOF mass spectrometry. The results indicated that none of the strains tested belonged to the species S. aureus. The rpoB sequences of five isolates showed the highest sequence similarity to S. haemolyticus, three isolates to S. chromogenes, and one isolate to S. epidermidis. One strain (SAL4) remained unidentified in this analysis. The results obtained using mass spectrometry were comparable to those based on gene sequence analysis. Strain SAL4, which could not be identified by sequencing, was identified by MALDI-TOF as Staphylococcus chromogenes.
Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours
Authors: Sennazli Gulbin , Yildirim Funda , Serdar Arun Seckin , Gurel Aydin , Sonmez Kivilcim 
Published: July 2015

Abstract
The objective of this study was to investigate the correlation between different histological types and grades of canine malignant mammary tumours, tumour cell proliferation and their angiogenic activity using immunohistochemical markers. Mammary tissue samples from 47 bitches with mammary cancer were evaluated. The expression of cellular proliferation marker Ki-67 and endothelial marker Von Willebrand’s factor (vWF) were immunohistochemically demonstrated. The tumours with the highest Ki-67 and vWF expressions were found to share similar histomorphological features. Simple solid carcinoma had the highest levels of Ki-67, vWF, and higher histological grade while complex carcinomas, osteosarcomas, and carcinosarcomas had the lowest ones. The differences between the expressions of Ki-67 and vWF in different tumour types were considered to be of great importance in determination of biological behaviour and prognosis of these tumours. This study is one of the few studies that evaluate these differences among the subtypes of malignant canine mammary tumours
Effects of flunixin and florfenicol combined with vitamins E and/or C on selected immune mechanisms in cattle under conditions of adaptive stress
Authors: Urban-Chmiel Renata , Stachura Rafał , Hola Piotr , Puchalski Andrzej , Dec Marta , Wernicki Andrzej 
Published: July 2015

Abstract
The aim of the study was to evaluate the effect of flunixin and florfenicol administered in combination with vitamin E or C on selected leukocyte immune mechanisms and on the inflammatory process during the first few weeks in the feedlot. Fifty calves divided into 5 groups (n = 10) received florfenicol and flunixin with vitamin E or C. Blood was collected on the 1st, 3rd, 7th, 14th, 21st, and 28th d of the experiment. Intracellular metabolism (NBT), apoptosis, chemotaxis, susceptibility to M. haemolytica leukotoxin, and expression of β2-integrins were determined in leukocytes. The symptoms of respiratory tract infection were observed in 40% of calves in control group, while in the other groups the morbidity rate ranged from 10% to 20%. Leukocytes showed decreased NBT, and the mean values for apoptosis ranged from 14% to 24%. The lowest percentage of apoptotic cells was observed in the calves that received florfenicol with flunixin and vitamins E and C. The chemotactic activity confirmed the significant inhibitory effect of the preparations on migration of the cells. A significant decrease (P ≤ 0.05) in the susceptibility of leukocytes to leukotoxin was noted in the group that received florfenicol and flunixin with vitamin E. Expression of β2-integrin receptors was the lowest in calves receiving florfenicol with flunixin and vitamin E or C. The application of an antibiotic and a non-steroidal anti-inflammatory drug with antioxidants protected the leukocytes involved in defence against M. haemolytica virulence factors and effectively limited oxidative stress in the calves.
Role of insulin during the development of oligofructose (OF)-induced equine laminitis
Authors: Jiang Renli , Gao Li , Wang Guanying , Li Xinran , Li Yue , Fan Xiaojing , Liu Xu , Wang Jinglu , Zhang Yu , Kong Xiangxing , Xiao Jianhua 
Published: July 2015

Abstract
Horses (n = 20) were divided into 2 groups: oligofructose (OF)-induced equine laminitis group (group OF; n = 11) which received 10 g/kg b.w. of OF dissolved in 4 L water via nasogastric intubation, and control group (NS; n = 9) which received 4 L of saline. Blood was collected at 4 h intervals over 72 h study period and analysed by ELISA, kinetic limulus amoebocyte lysate assay, and glucose-oxidase methods. The level of insulin changed significantly in horses which received OF (P < 0.01); there was a significant negative correlation between the level of adiponectin and insulin over time. The results suggested that insulin may play an important role in the development of OF-induced equine laminitis by altering the level of endothelin-1 and nitric oxide.