bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children
Authors: Brix Ninna , Rosthøj Steen , Herlin Troels , Hasle Henrik 
Published: July 2015

BackgroundAt disease onset, children with acute lymphoblastic leukaemia (ALL) may present with arthralgia or even signs of arthritis. This might cause misdiagnosis and thereby lead to prolonged diagnostic delay. The present study aimed to identify children with ALL with joint involvement and to compare their characteristics and outcome with children with ALL without joint involvement.MethodsCase records of 286 children diagnosed with ALL between 1992 and 2013 were reviewed and analysed in this retrospective, descriptive study.ResultsFifty-three (18.5%) children with ALL presented with localised joint pain, and half of them had objective signs of arthritis. The mean number of joints involved was 2.5, most frequently presenting as asymmetric oligoarthritis. The suspected misdiagnosis were reactive arthritis (19/53), osteomyelitis (9/53) and juvenile idiopathic arthritis (8/53). Children with joint involvement had less objective signs of haematological disease. Cytopenia was absent in 24% in children with joint involvement (vs 8% without, p=0.001), 50% had only one cell line affected (vs 21%, p=0.0005) and 44% had no organomegaly (vs 29%, p=0.05). Median diagnostic delay was 4 vs 2 weeks. The 5-year event-free and overall survival was superior for children with joint involvement: 94% vs 87% (p=0.049), and 96% vs 83% (p=0.044).ConclusionsALL with joint involvement is a frequent finding (18.5%). The clinical signs of leukaemia are less prominent, but non-articular pain should alert the clinician of a possible diagnosis of leukaemia. The overall and event-free survivals were superior compared with the children without joint involvement.
Systemic and venous thromboembolism: think about paradoxical embolism
Authors: Cachia Monique , Pace Bardon Michael , Fsadni Peter , Montefort Stephen 
Published: July 2015

Patent foramen ovale (PFO) is one of the most important causes of paradoxical embolism; it is found in about 25–30% of the population. In most patients, it is asymptomatic and diagnosis is usually made during routine echocardiography. In a small proportion of patients, PFO is diagnosed after paradoxical embolism is suspected. We present a case of a middle-aged smoker who was admitted with lower limb deep vein thrombosis and pulmonary embolism, who developed acute upper limb ischaemia during his inpatient stay. Since doctors might dismiss such cases as routine, this report highlights the importance of detailed history taking and examination in patients with venous thromboembolism. Paradoxical embolism should always be considered as a possible diagnosis when managing patients with concomitant venous and arterial embolism.
“Anybody on this list that you're more worried about?” Qualitative analysis exploring the functions of questions during end of shift handoffs
Authors: O'Brien Colleen M , Flanagan Mindy E , Bergman Alicia A , Ebright Patricia R , Frankel Richard M 
Published: July 2015

BackgroundShift change handoffs are known to be a point of vulnerability in the quality, safety and outcomes of healthcare. Despite numerous efforts to improve handoff reliability, few interventions have produced lasting change. Although the opportunity to ask questions during patient handoff has been required by some regulatory bodies, the function of questions during handoff has been less well explored and understood.ObjectiveTo investigate questions and the functions they serve in nursing and medicine handoffs.Research designQualitative thematic analysis based on audio recordings of nurse-to-nurse, medical resident-to-resident and surgical intern-to-intern handoffs.SubjectsTwenty-seven nurse handoff dyads and 18 medical resident and surgical intern handoff dyads at one VA Medical Center.ResultsOur analysis revealed that the vast majority of questions were asked by the Incoming Providers. Although topics varied widely, the bulk of Incoming Provider questions requested information that would best help them understand individual patient conditions and plan accordingly. Other question types sought consensus on clinical reasoning or framing and alignment between the two professionals.ConclusionsHandoffs are a type of socially constructed work. Questions emerge with some frequency in virtually all handoffs but not in a linear or predictable way. Instead, they arise in the moment, as necessary, and without preplanning. A checklist cannot model this process element because it is a static memory aid and questions occur in a relational context that is emergent. Studying the different functions of questions during end of shift handoffs provides insights into the interface between the technical context in which information is transferred and the social context in which meaning is created.
Determination of a shear rate threshold for thrombus formation in intracranial aneurysms
Authors: Ribeiro de Sousa Daniel , Vallecilla Carolina , Chodzynski Kamil , Corredor Jerez Ricardo , Malaspinas Orestis , Eker Omer Faruk , Ouared Rafik , Vanhamme Luc , Legrand Alexandre , Chopard Bastien , Courbebaisse Guy , Zouaoui Boudjeltia Karim 
Published: July 2015

BackgroundParticular intra-aneurysmal blood flow conditions, created naturally by the growth of an aneurysm or induced artificially by implantation of a flow diverter stent (FDS), can potentiate intra-aneurysmal thrombosis. The aim of this study was to identify hemodynamic indicators, relevant to this process, which could be used as a prediction of the success of a preventive endovascular treatment.MethodA cross sectional study on 21 patients was carried out to investigate the possible association between intra-aneurysmal spontaneous thrombus volume and the dome to neck aspect ratio (AR) of the aneurysm. The mechanistic link between these two parameters was further investigated through a Fourier analysis of the intra-aneurysmal shear rate (SR) obtained by computational fluid dynamics (CFD). This analysis was first applied to 10 additional patients (4 with and 6 without spontaneous thrombosis) and later to 3 patients whose intracranial aneurysms only thrombosed after FDS implantation.ResultsThe cross sectional study revealed an association between intra-aneurysmal spontaneous thrombus volume and the AR of the aneurysm (R2=0.67, p<0.001). Fourier analysis revealed that in cases where thrombosis occurred, the SR harmonics 0, 1, and 2 were always less than 25/s, 10/s, and 5/s, respectively, and always greater than these values where spontaneous thrombosis was not observed.ConclusionsOur study suggests the existence of an SR threshold below which thrombosis will occur. Therefore, by analyzing the SR on patient specific data with CFD techniques, it may be potentially possible to predict whether or the intra-aneurysmal flow conditions, after FDS implantation, will become prothrombotic.
Ophiolitic rocks of the Indo-Myanmar Ranges, NE India: relicts of an inverted and tectonically imbricated hyper-extended continental margin basin?
Authors: Soibam I. , Khuman M. Ch. , Subhamenon S. S. 
Published: July 2015

Abstract
The Indo-Myanmar Ranges (IMR) of NE India are host to various ophiolitic rocks, including metamorphosed Alpine-type harzburgite and lherzolite. Compared to abyssal peridotites of normal oceanic lithosphere, these ultramafic rocks are enriched in trace and rare earth elements. Spilitic pillow lavas along with mafic dykes and sills locally intruded into the serpentinized ultramafic rocks and associated pelagic sediments exhibit alkaline compositional affinities. Ophiolite formation and emplacement were by a process analogous to that described for mantle exhumation in hyper-extended continental margin settings and ophiolites in parts of the European Alps, involving very slow passive continental margin rifting accompanied by slow upwelling or extensional unroofing of the subcontinental upper mantle up to the seafloor. Preliminary palaeomagnetic measurements conducted on ultramafic rocks within the IMR ophiolite belt give a virtual geomagnetic pole (VGP) at 47° N, 045° E for thermal demagnetization (TDM) measurements and 33° N, 013° E for the alternating field demagnetization (AfD) measurements, requiring an anticlockwise rotation of the ultramafic bodies by 14° during the subduction process. The original trend of the spreading axis of the ophiolites was probably NE–SW, with spreading directed NW–SE. Computation of palaeolatitude of the ultramafic rocks gives an average value of 24.67°. Comparison between the palaeolatitude and the present latitude of the sample sites provides a mere latitudinal shift of less than 1°.
Field studies, combined with an analysis of structural and tectonic features in the IMR, suggest a generalized WNW–ESE (east–west) compression and NNE–SSW (north–south) extension contradictory to the NNE–SSW contraction indicated by seismic data. Area balancing techniques employed along sections orientated perpendicular to regional tectonic strike in the IMR reveal systematic variations in the amount of crustal shortening, with a maximum of approximately 60% recorded in the Nagaland–Manipur segment along 25.644° N, 93.826° E–25.076° N, 95.897° E. The amount of shortening gradually decreases away from the axis of maximum shortening and on both sides. Calculations of relative plate motion based on rotation vectors given by different workers for various plate pairs represented in the region reveal that the interaction between the Indian and Myanmar plates can ideally produce the structural and tectonic features of this range. Dextral shear coupled to oblique subduction of the Indian Plate below the Myanmar Plate can best explain all of the structural and tectonic features present in the IMR.
Deformation capture and modeling of soft objects
Authors: Wang Bin , Wu Longhua , Yin KangKang , Ascher Uri , Liu Libin , Huang Hui 
Published: July 2015

We present a data-driven method for deformation capture and modeling of general soft objects. We adopt an iterative framework that consists of one component for physics-based deformation tracking and another for spacetime optimization of deformation parameters. Low cost depth sensors are used for the deformation capture, and we do not require any force-displacement measurements, thus making the data capture a cheap and convenient process. We augment a state-of-the-art probabilistic tracking method to robustly handle noise, occlusions, fast movements and large deformations. The spacetime optimization aims to match the simulated trajectories with the tracked ones. The optimized deformation model is then used to boost the accuracy of the tracking results, which can in turn improve the deformation parameter estimation itself in later iterations. Numerical experiments demonstrate that the tracking and parameter optimization components complement each other nicely.
Our spacetime optimization of the deformation model includes not only the material elasticity parameters and dynamic damping coefficients, but also the reference shape which can differ significantly from the static shape for soft objects. The resulting optimization problem is highly nonlinear in high dimensions, and challenging to solve with previous methods. We propose a novel splitting algorithm that alternates between reference shape optimization and deformation parameter estimation, and thus enables tailoring the optimization of each subproblem more efficiently and robustly.
Our system enables realistic motion reconstruction as well as synthesis of virtual soft objects in response to user stimulation. Validation experiments show that our method not only is accurate, but also compares favorably to existing techniques. We also showcase the ability of our system with high quality animations generated from optimized deformation parameters for a variety of soft objects, such as live plants and fabricated models.
Seamless surface mappings
Authors: Aigerman Noam , Poranne Roi , Lipman Yaron 
Published: July 2015

We introduce a method for computing seamless bijective mappings between two surface-meshes that interpolates a given set of correspondences.
A common approach for computing a map between surfaces is to cut the surfaces to disks, flatten them to the plane, and extract the mapping from the flattenings by composing one flattening with the inverse of the other. So far, a significant drawback in this class of techniques is that the choice of cuts introduces a bias in the computation of the map that often causes visible artifacts and wrong correspondences.
In this paper we develop a surface mapping technique that is indifferent to the particular cut choice. This is achieved by a novel type of surface flattenings that encodes this cut-invariance, and when optimized with a suitable energy functional results in a seamless surface-to-surface map.
We show the algorithm enables producing high-quality seamless bijective maps for pairs of surfaces with a wide range of shape variability and from a small number of prescribed correspondences. We also used this framework to produce three-way, consistent and seamless mappings for triplets of surfaces.
Dyadic T-mesh subdivision
Authors: Kovacs Denis , Bisceglio Justin , Zorin Denis 
Published: July 2015

Meshes with T-joints (T-meshes) and related high-order surfaces have many advantages in situations where flexible local refinement is needed. At the same time, designing subdivision rules and bases for T-meshes is much more difficult, and fewer options are available. For common geometric modeling tasks it is desirable to retain the simplicity and flexibility of commonly used subdivision surfaces, and extend them to handle T-meshes.
We propose a subdivision scheme extending Catmull-Clark and NURSS to a special class of quad T-meshes, dyadic T-meshes, which have no more than one T-joint per edge. Our scheme is based on a factorization with the same structure as Catmull-Clark subdivision. On regular T-meshes it is a refinement scheme for a subset of standard T-splines. While we use more variations of subdivision masks compared to Catmull-Clark and NURSS, the minimal size of the stencil is maintained, and all variations in formulas are due to simple changes in coefficients.
Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer
Authors: Li Tong , Wang Yak-Nam , Khokhlova Tatiana D. , D'Andrea Samantha , Starr Frank , Chen Hong , McCune Jeannine S. , Risler Linda J. , Mashadi-Hossein Afshin , Hingorani Sunil R. , Chang Amy , Hwang Joo Ha 
Published: July 2015

Abstract
Pancreatic cancer is characterized by extensive stromal desmoplasia, which decreases blood perfusion and impedes chemotherapy delivery. Breaking the stromal barrier could both increase perfusion and permeabilize the tumor, enhancing chemotherapy penetration. Mechanical disruption of the stroma can be achieved using ultrasound-induced bubble activity—cavitation. Cavitation is also known to result in microstreaming and could have the added benefit of actively enhancing diffusion into the tumors. Here, we report the ability to enhance chemotherapeutic drug doxorubicin penetration using ultrasound-induced cavitation in a genetically engineered mouse model (KPC mouse) of pancreatic ductal adenocarcinoma. To induce localized inertial cavitation in pancreatic tumors, pulsed high-intensity focused ultrasound (pHIFU) was used either during or before doxorubicin administration to elucidate the mechanisms of enhanced drug delivery (active vs. passive drug diffusion). For both types, the pHIFU exposures that were associated with high cavitation activity resulted in disruption of the highly fibrotic stromal matrix and enhanced the normalized doxorubicin concentration by up to 4.5-fold compared with controls. Furthermore, normalized doxorubicin concentration was associated with the cavitation metrics (P &lt; 0.01), indicating that high and sustained cavitation results in increased chemotherapy penetration. No significant difference between the outcomes of the two types, that is, doxorubicin infusion during or after pHIFU treatment, was observed, suggesting that passive diffusion into previously permeabilized tissue is the major mechanism for the increase in drug concentration. Together, the data indicate that pHIFU treatment of pancreatic tumors when resulting in high and sustained cavitation can efficiently enhance chemotherapy delivery to pancreatic tumors. Cancer Res; 75(18); 3738–46. ©2015 AACR.
Time Trends in Rates of Hodgkin Lymphoma Histologic Subtypes: True Incidence Changes or Evolving Diagnostic Practice?
Authors: Glaser Sally L. , Clarke Christina A. , Keegan Theresa H.M. , Chang Ellen T. , Weisenburger Dennis D. 
Published: July 2015

AbstractBackground: Histologic subtypes of classical Hodgkin lymphoma [cHL; e.g., nodular sclerosis, mixed cellularity, not otherwise specified (NOS)] are epidemiologically and prognostically distinctive. Therefore, unexplained, ongoing incidence rate declines for mixed cellularity and increases for NOS require examination.Methods: We analyzed detailed histology-specific Hodgkin lymphoma incidence rates in 1992 through 2011 U.S. SEER data (n = 21,372) and reviewed a regional subset of 2007 through 2011 NOS pathology reports for insight into diagnostic practices.Results: cHL rates were stable until 2007, then decreased for whites [annual percent change (APC) and 95% confidence interval (CI), −3.6% (−5.6% to −1.5%)]. Nodular sclerosis rates declined after 2007 by 5.9% annually, with variation by gender, age, and race/ethnicity. In 1992 through 2011, mixed cellularity rates declined [APC −4.0% (−4.7% to −3.3%)], whereas NOS rates rose [5.3% (4.5%–6.2%)] overall and in most patient groups. The 2007–2011 NOS age-specific rates were more similar to mixed cellularity rates for 1992–1996 than 2007–2011. Trends in combined rates were minimal, supporting increasing misclassification of mixed cellularity, lymphocyte depletion, and specific nodular sclerosis subtypes as NOS. Eighty-eight of 165 reviewed NOS pathology reports addressed classification choice. Twenty (12.1%) justified the classification, 21 (12.7%) described insufficient biopsy material, and coders missed specific subtype information for 27 (16.4%).Conclusion: Recent nodular sclerosis rate declines largely represent true incidence changes. Long-term rate decreases for mixed cellularity and other less common subtypes, and increases for NOS (comprising ∼30% of cHL cases in 2011), likely reflect changes in diagnostic and/or classification practice.Impact: Diminishing histologic subtyping undermines future surveillance and epidemiologic study of Hodgkin lymphoma. Guideline-based use of excisional biopsies and more coding quality control are warranted. Cancer Epidemiol Biomarkers Prev; 24(10); 1474–88. ©2015 AACR.
Ще раз про походження літописного Вердерева
Authors: Шульгач [Shul'gach] Віктор [Viktor] П. [P.] 
Published: July 2015

Ethymology of the place name Вердеревъ The oiconym Вердеревъ is mentioned in a document from the end of the 14th century. The historical place name is connected with today's name of a village in Skopin region, Riazan district. Some scientists observe a connection between the name with a hydronym Вердa (V.P. Neroznak, M.H. Tyhomyrov, M.A. Yuyukin). This explanation was called into question by the author: he proves that the oiconym Вердерев needs to be connected with a toponym Верх Дерево and adduces numerous similar geographic names in Slavic lands. Ещё раз об этимoлогии ойконима ВердеревъНазвание Вердеревъ упоминается в списке наименований городов российских от XIV в. Историческое летописное название связано с названием поселения, находящегося в Скопинском районе Рязанской области. По мнению некоторых учёных (Нерознак, Tихoмиpoв, Ююкин) данное название надо связывать с гидронимом Верда. Автор статьи предлагает другое толкование, считая, что ойконим Вердеревъ следует рассматривать в связи с топонимом Верх Дерево. На подтвержление своего мнения автор приводит ряд подобных географических названий, зафиксированных на всей славянской территории.
Predictability of the California Niño/Niña*
Authors: Doi Takeshi , Yuan Chaoxia , Behera Swadhin K. , Yamagata Toshio 
Published: July 2015

Abstract
Predictability of a recently discovered regional coupled climate mode called the California Niño (Niña) off Baja California and California is explored using a seasonal prediction system based on the Scale Interaction Experiment-Frontier, version 1 (SINTEX-F1) coupled ocean–atmosphere general circulation model. Because of the skillful prediction of basin-scale El Niño (La Niña), the California Niño (Niña) that co-occurs with El Niño (La Niña) with a peak in boreal winter is found to be predictable at least a couple of seasons ahead. On the other hand, the regional coupled phenomenon peaking in boreal summer without co-occurrence with El Niño (La Niña) is difficult to predict. The difficulty in predicting such an intrinsic regional climate phenomenon may be due to model deficiency in resolving the regional air–sea–land positive feedback processes. The model may also underestimate coastal Kelvin waves with a small offshore scale, which may play an important role in the generation of the California Niño/Niña. It may be improved by increasing horizontal resolution of the ocean component of the coupled model. The present study may provide a guideline to improve seasonal prediction of regional climate modes for important industrial as well as social applications.
Anthropogenic Weakening of the Tropical Circulation: The Relative Roles of Direct CO2 Forcing and Sea Surface Temperature Change
Authors: He Jie , Soden Brian J. 
Published: July 2015

Abstract
There is a lack of consensus on the physical mechanisms that drive the anthropogenic weakening of tropical circulation. This study investigates the relative roles of direct CO2 forcing, mean SST warming, and the pattern of SST change on the weakening of the tropical circulation using an ensemble of AMIP and aquaplanet simulations. In terms of the mean weakening of the tropical circulation, the SST warming dominates over the direct CO2 forcing through its control over the tropical mean hydrological cycle and tropospheric stratification. In terms of the spatial pattern of circulation weakening, however, the three forcing agents are all important contributors, especially over the ocean. The increasing CO2 weakens convection over ocean directly by stabilizing the lower troposphere and indirectly via the land–sea warming contrast. The mean SST warming drives strong weakening over the centers and edges of convective zones. The pattern of SST warming plays a crucial role on the spatial pattern of circulation weakening over the tropical Pacific.
The anthropogenic weakening of the Walker circulation is mostly driven by the mean SST warming. Increasing CO2 strengthens the Walker circulation through its indirect effect on land–sea warming contrast. Changes in the upper-level velocity potential indicate that the pattern of SST warming does not weaken the Walker circulation despite being “El Niño–like.” A weakening caused by the mean SST warming also dominates changes in the Hadley circulation in the AMIP simulations. However, this weakening is not simulated in the Southern Hemisphere in coupled simulations.