bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitrates of cerium and samarium deposit on human enamel independently of a salivary pellicle
Authors: Kopp Louis , Hiller Karl-Anton , Cieplik Fabian , Pfitzner Arno , Pielnhofer Florian , Höfler Bastian , Dolle Christian , Lennon Áine M. , Bauer Sophia R. , Buchalla Wolfgang , Scholz Konstantin J. 
Published: August 2024

ObjectivesThe aim of this study was to analyze the precipitation of Cerium(III)nitrate hexahydrate [Ce(NO3)3] or Samarium(III)nitrate hexahydrate [Sm(NO3)3] solutions on human enamel with and without a salivary pellicle. Investigated parameters were At%Ce and At%Sm measured using energy dispersive x-ray spectroscopy (EDX) after test solution (two concentrations) application.Materials and methodsPrecipitation of Ce(NO3)3 and Sm(NO3)3 solutions was examined on human enamel with and without a salivary pellicle. 6 enamel specimens each were obtained from 12 freshly extracted human third molars. These specimens were ground flat and polished. A salivary pellicle was created on 3 of the 6 specimens per tooth by storing the samples in human saliva. Subsequently, an aqueous solution of Ce(NO3)3 was applied to 2 of the 6 specimens (one with, one without salivary pellicle) for 60 s. The same was carried out with an aqueous solution of Sm(NO3)3 on 2 further specimens. The remaining 2 specimens from each tooth were treated with demineralized water (negative control). Ce(NO3)3 and Sm(NO3)3 solutions were applied at 25 or 50 wt% (aqueous solutions). The test materials and concentrations were distributed using a randomization table. After 60 s exposure and rinsing with demineralized water, the elemental composition (Ce, Sm, Ca, P, O, N, Na, Mg) of the enamel surface was analyzed by EDX. Atomic percentages (At%), differences (ΔAt%) and calcium/phosphorous-ratios (Ca/P-ratios) were calculated and analyzed non-parametrically (α = 0.05).Results2.0–2.3 At%Ce (median) was detected on Ce(NO3)3-treated enamel and 0.4–0.7 At% Sm (median) was detected on Sm(NO3)3-treated enamel. Ce was only detected on the surfaces after application of Ce(NO3)3, Sm only after application of Sm(NO3)3. The Ca/P-ratio was significantly lower (1.37–1.59; p = 0.028) after the application of 25% and 50%Ce(NO3)3 as well as 50%Sm(NO3)3 compared to the control treatment (demineralized water; 1.61–1.63). After treatment with Ce(NO3)3, At%Ca and At%Na were significantly lower (p ≤ 0.043) compared to treatment with Sm(NO3)3. No significant differences were found between specimens treated with 25% or 50% lanthanide nitrate solution. Presence of a salivary pellicle had no significant influence on the measured At% with the exception of specimens treated with 50% Sm(NO3)3 with increased At%Sm (p ≤ 0.046).ConclusionsCe(NO3)3 and Sm(NO3)3 precipitate on human enamel independently of the presence of a salivary pellicle.
Free circulating versus extracellular vesicle-associated microRNA expression in canine T-cell lymphoma
Authors: Capuano Cecilia , Moccia Valentina , Molinari Antonella , Torrigiani Filippo , Ferro Livia , Ferraresso Serena , Bonsembiante Federico , Leo Chiara , Zappulli Valentina 
Published: August 2024

IntroductionCanine lymphoma (cL) is one of the most frequent cancers in dogs. The T-cell lymphoma (TcL) is not the most common phenotype but presents an aggressive behavior. MicroRNAs (miRNAs), are small, single-stranded, non-coding RNA molecules which can circulate freely in blood or be associated with extracellular vesicles (EVs). The dysregulation of certain miRNAs has been identified in numerous types of human cancers and they have been largely investigated as possible tumors biomarkers in human medicine, while research in veterinary oncology is still scarce. The aim of this study was to compare the expression patterns of free circulating and EV-associated miRNAs in dogs with T-cell lymhoma (TcL) and healthy dogs.MethodsEight dogs with TcL were selected as the lymphoma group (LG) and eight dogs were included as controls (Ctrl). Plasma samples were collected at the time of the diagnosis and EVs isolated with ultracentrifugation. miRNAs were extracted from both the circulating EVs and the plasma supernatant, obtaining EV-associated and free-miRNAs. Quantitative real-time PCR was performed to analyze the expression of 88 target miRNAs.ResultsTen and seven differentially expressed miRNAs between LG and Ctrl were detected in EV-associated and free-miRNAs, respectively. Among EV-associated and free-miRNAs, only has-miR-222-3p was overexpressed in both conditions.DiscussionAll the differentially expressed miRNAs detected in this study, have been already described as dysregulated in other human or canine cancers. The EV-associated miRNAs, which appear to be more stable and better conserved than free-miRNAs, could be investigated in further larger studies to better assess their use as possible biomarkers for TcL.
Antibody-Mediated Rejection in Liver Transplantation: Immuno-Pathological Characteristics and Long-Term Follow-Up
Authors: Cicalese Luca , Walton Zachary C. , Du Xiaotang , Kulkarni Rupak , Qiu Suimin , El Hag Mohamed , Stevenson Heather L. 
Published: August 2024

The diagnosis of liver antibody-mediated rejection (AMR) is challenging and likely under-recognized. The association of AMR with donor-specific antibodies (DSA), and its clinical course in relation to pathologic findings and treatment are ill defined. We identified cases of liver AMR by following the criteria outlined by the 2016 Banff Working Group. Patient demographics, native liver disease, histopathologic findings, treatment type, clinical outcome, and transaminase levels during AMR diagnosis, treatment, and resolution were determined. Patients (n = 8) with AMR average age was 55.2 years (range: 19–68). Seven of eight cases met the Banff criteria for AMR. Personalized treatment regimens consisted of optimization of immunosuppression, intravenous pulse steroids, plasmapheresis, IVIG, rituximab, and bortezomib. Five patients experienced complete resolution of AMR, return of transaminases to baseline, and decreased DSA at long-term follow-up. One patient developed chronic AMR and two patients required re-transplantation. Follow-up after AMR diagnosis ranged from one to 11 years. Because AMR can present at any time, crossmatch, early biopsy, and routine monitoring of DSA levels should be implemented following transaminase elevation to recognize AMR. Furthermore, treatment should be immediately implemented to reverse AMR and prevent graft failure, chronic damage, re-transplantation, and possibly mortality.
Development of a Multiplex Real-Time PCR to Disambiguate Culicoides sonorensis within Culicoides variipennis Complex, the Proven Vector of Bluetongue and Epizootic Hemorrhagic Disease Viruses in North America
Authors: Paquette Sarah-Jo , Czekay Dominic , Manalaysay Jessica , Furukawa-Stoffer Tara , Ambagala Aruna , Vigil Stacey , Shahhosseini Nariman 
Published: August 2024

Species delimitation of Culicoides complex species can be challenging. Among species within the Culicoides variipennis complex, C. sonorensis is considered the primary vector of bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) in North America. Morphological identification of C. sonorensis within the C. variipennis complex is laborious, time-consuming, and requires entomology expertise. Therefore, in this study we developed and validated a multiplex real-time PCR for rapid detection and differentiation of C. sonorensis from the two other main cryptic species (C. variipennis and C. occidentalis) within the C. variipennis complex. The assay targets the EF1α gene and has a built-in internal control targeting 18 S. The specificity and the sensitivity of the multiplex real-time PCR were evaluated using morphologically identified reference and field-collected specimens. The multiplex PCR was 100% specific when nucleic acid extracted from C. variipennis, sonorensis, and occidentalis specimens was tested. When nucleic acid extracted from pools of midges was tested, the multiplex PCR was able to detect all three Culicoides species with comparable sensitivity. The multiplex assay, however, failed to detect eight morphologically identified C. sonorensis specimens collected from Alberta in 2014. The EF1α gene sequences of these specimens formed a distinct phylogenetic cluster, amongst those from C. variipennis, sonorensis, and occidentalis, suggesting that they belong to a different species. We hypothesize that those specimens might be C. albertensis, the only other species remaining in the C. variipennis complex with known geographical distribution in North America. We believe that this highly sensitive and specific multiplex real-time PCR assay could be an effective tool for rapid detection and differentiation of C. sonorensis, the known vector of BTV and EHDV, in trap collections in future vector surveillance programs.
Hypochloremia: A Potential Indicator of Poor Outcomes in COVID-19
Authors: Barkay Orçun , Karakeçili Faruk 
Published: August 2024

Background: Coronavirus Disease-2019 (COVID-19) has posed formidable challenges to healthcare systems. Exploring novel biomarkers that can provide valuable prognostic insights, particularly in critically ill patients, has a significant importance. Against this backdrop, our study aims to elucidate the associations between serum chloride levels and clinical outcomes. Methods: A total of 499 patients were enrolled into the study. The serum chloride levels of patients upon hospital admission were recorded and then categorized into three groups (hypochloremia, normochloremia, and hyperchloremia) for the evaluation of clinical outcomes. Additionally, serum C-reactive protein, procalcitonin, and D-dimer measurements were recorded for further evaluation. Results: A total of 390 (78.1%) patients tested positive for COVID-19 via polymerase chain reaction testing. Non-contrast thorax computed tomography scans were indicative of COVID-19 compatibility for all patients. A total of 210 (42%) patients were female and 289 (58%) were male. A total of 214 (42.8%) patients necessitated tocilizumab intervention; 250 (50.1%) were at an intensive care unit (ICU), with 166 (66.4%) of them receiving tocilizumab. A total of 65 (13%) patients died, 40 (61.5%) of whom received tocilizumab; 41 (63%) were in the ICU. Serum chloride levels upon admission were markedly lower and elevated D-dimer levels were apparent in tocilizumab users, patients requiring ICU care, and patients who died. Conclusions: our findings provide robust evidence supporting the value of serum chloride levels as a prognostic biomarker in critically ill COVID-19 patients.
Satellite-Derived Bathymetry Using a Fast Feature Cascade Learning Model in Turbid Coastal Waters
Authors: Wu Zhongqiang , Zhao Yuchen , Wu Shulei , Chen Huandong , Song Chunhui , Mao Zhihua , Shen Wei 
Published: August 2024

Obtaining accurate bathymetric maps is very valuable for marine environment monitoring, port planning, and so on. Accurately estimating water depth in turbid coastal waters using satellite remote sensing encounters challenges originating from low water transparency, but it is limited by the quantity, quality, and water quality of samples. This study introduces a fast feature cascade learning model (FFCLM) to enhance the accuracy of bathymetric inversion from multispectral satellite images, particularly when limited field samples are available. FFCLM leverages spectral bands and in situ data to derive effective inversion weights through feature concatenation and cascade fitting. Field experiments conducted at Nanshan Port and Rushikonda Beach gathered water depth, satellite, and in situ data. Comparative analysis with conventional machine learning algorithms, including support vector machine, random forest, and gradient boosting trees, indicates that FFCLM achieves lower errors and demonstrates more robust performance across study areas. This is especially more pronounced when using small training samples (
n
< 100). Examination of key parameters and water depth profiles highlights FFCLM’s advantages in generalization and deep-water inversion. This study presents an efficient solution for small-sample bathymetric mapping in turbid coastal waters, utilizing spectral and physical information to overcome sample size limitations and enhancing satellite remote sensing capabilities for shallow water monitoring.
O PPGEDUCAMPO/UFRB e a formação da classe trabalhadora do campo
Authors: Lima Silvana Lucia da Silva , Araújo Maria Nalva Bogo de , Pizetta Adelar João 
Published: August 2024

Este artigo traz apontamentos sobre os referenciais teóricos e as contribuições do Programa de Pós-graduação strictu sensu em Educação do Campo na formação da classe trabalhadora do campo. Articulando as categorias educação, trabalho e formação humana, evidencia como as contradições da sociedade capitalista e sua expressão no desenvolvimento agrário brasileiro foram determinantes na conquista da Educação do Campo enquanto política pública. Por fim, apresenta as contribuições do Programa, a partir dos trabalhos de conclusão de curso, com a luta por um projeto popular para o campo brasileiro.
The Influence of Individual Factors and Work Conditions with Nurse's Mental Workload Using Method Nasa-TLX Banggai District Health Center
Authors: Busura Aldi , Mulasari Surahma Asti , Kristanto Agung 
Published: August 2024

Workload is the interaction between individuals and things that can burden someone in completing work. The workload is divided into physical and mental, where the workload is influenced by individual characteristics and external factors, task demands, and work environment. The prevalence of workload in the province of Central Sulawesi (50.9%) experienced work stress caused by excessive workload. Banggai Regency is one of the regions in the province of Central Sulawesi. The purpose of this study was to find out how individual characteristics and working conditions can affect the mental workload of nurses at the Banggai District Health Center. this study uses the chi-square method. The sample used in this study is a nurse who is actively working at the Banggai District Health Center. The number of samples used is 225 nurses. The sampling technique is the Slovin technique. The measuring tool used is a research questionnaire from NASA TLX. This questionnaire is used to measure the mental workload of nurses at the Banggai District Health Center. Data were analyzed by univariate and bivariate. The results of this study indicate that the mental workload of nurses in Banggai Regency is in the high category (70.2%). The results of the bivariate analysis found that there was a relationship between age, task demands, work environment and the mental workload of nurses at the Banggai District Health Center (p-value 0.000). There is no relationship between gender and the mental workload of nurses at the Banggai District Health Center. The results of the multivariate analysis of age and task demands have a positive effect on workload, while the work environment has a negative effect on workload. The work environment is the most dominant factor affecting the mental workload of nurses at the Banggai District Health Center
PEMUCATAN MINYAK HATI IKAN CUCUT PISANG (CHARCHARINUS FALCIFORMIS) MENGGUNAKAN MAGNESOL XL
Authors: Rozi Anhar 
Published: August 2024

Hati ikan cucut diketahui banyak mengandung minyak yang dapat digunakan sebagai obat-obatan, 50% dari total minyak ikan cucut terdapat pada bagian hati. Penelitian ini dilakukan bertujuan untuk meningkatkan kualitas minyak kasar hati ikan cucut menggunakan magnesol XL. Metode pengujian kualitas minyak ikan mengacu pada AOAC. Perlakuan yang digunakan yaitu pemucatan menggunakan magnesol XL (1%, 3%, dan 5%). Hasil pemucatan menunjukkan bahwa magnesol XL dapat meningkatkan kualitas minyak hati cucut pisang. Minyak hasil pemucatan menggunakan magnesol XL 3% merupakan perlakuan terbaik. Pemucatan dengan menggunakan magnesol XL 3% menghasilkan minyak dengan kualitas nilai (FFA: 0,28±0,00%; PV: 1,66±0,46 mEq/kg; p-AV: 6,36±0,20 mEq/kg; TOTOX: 9,02±1,13 mEq/kg; AV: 0,56±0,00 mg KOH/kg; kejernihan: 76,43±0,91%; viskositas : 31,81±0,46 cP). Kata kunci: magnesol XL, minyak ikan, pemucatan
Kajian Implementasi Good Manufacturing Practices Pada Pengolahan Lokan Crispy Di KUB Rizki Sabena, Kabupaten Aceh Singkil
Authors: Maulida Indah , Ukhty Nabila 
Published: August 2024

Lokan crispy merupakan salah satu produk olahan pangan yang di produksi oleh Kelompok Usaha Perikanan (KUB) Rizki Sabena. KUB Rizki Sabena adalah salah satu Unit Pengolahan Ikan (UPI) yang ada di Kabupaten Aceh Singkil. Penelitian ini bertujuan untuk melihat implementasi kelayakan dasar Good Manufacturing Practices (GMP) pada industri rumah tangga produk lokan crispy KUB Rizki Sabena Kabupaten Aceh Singkil. Penelitian ini terbagi menjadi empat tahapan yaitu survey lokasi, persiapan penelitian, pengumpulan data dan analisis data deskriptif kualitatif. Data yang dikumpulkan dalam penelitian ini berupa data primer dan sekunder. Data primer didapat melalui metode wawancara, partisipasi aktif dan observasi langsung, sedangkan data sekunder didapat dari data Dinas Perikanan Kabupaten Aceh Singkil. KUB Rizki Sabena secara keseluruhan belum Optimal dalam menerapkan kelayakan dasar atau GMP pada usaha tersebut. Dari delapan parameter yang diteliti hanya ada tiga parameter yang diterapkan diantaranya yaitu Lingkungan dan lokasi, Bangunan dan fasilitas unit usaha, Fasilitas sarana dan prasarana dan kegiatan sanitasi. Sedangkan Parameter yang belum diterapkan diantaranya, belum adanya sistem pengendalian hama, kegiatan higienis karyawan, pengendalian pada setiap proses, manajemen pengawasan, serta pencatatan dan dokumentasi
Penambahan Jam Kerja sebagai Alternatif Percepatan Pekerjaan Konstruksi (Study Kasus Proyek Peningkatan Jalan di Kabupaten Buton Tengah)
Authors: Bahar Syamsul Bahri , Efendi Ahmad 
Published: August 2024

Proyek-proyek pemerintah di daerah pada umum waktu pelaksanaan pekerjaan sudah memasuki musim hujan, sehingga menyebabkan pekerjaan tidak selesai tepat waktu. Untuk itu perlu dilakukan percepatan pekerjaan dengan cara crash program atau dengan mempersingkat waktu pekerjaan. Perubahan jadwal ini tentu akan membawa pengaruh terhadap biaya secara umum. Waktu normal pelaksanaan pekerjaan proyek peningkatan jalan lakapera-wamengkoli 120 hari kalender sejak tanggal 15 Agustus 2022 sampai dengan tanggal 12 Desember 2022, dengan anggaran biaya pekerjaan sebesar Rp. 2.140.156.689,21. Project crashing dilakukan agar pekerjaan selesai dengan pertukaran silang waktu dan biaya dan dengan menambah jumlah jam kerja. Untuk mempercepat pelaksanaan pekerjaan Peningkatan Jalan di Kabupaten Buton Tahun Anggaran 2022 yang harus dilakukan membuat net work planning guna mengidentifikasi jalur kritis yang selanjutnya menghitung kurun waktu yang dipersingkat (crash duration) dan biaya tambahan pekerja (crash cost) serta cost slope masing-masing pekerjaan. Dari hasil penelitian disimpulkan dengan menambah 1 jam pekerjaan lembur maka dapat mempercepat waktu 118 hari dengan biaya Rp. 2.140.493.124,75, 2 jam mempercepat waktu 111 hari dengan biaya Rp. 2.143.208.225,04, 3 jam mempercepat waktu 102 hari dengan biaya Rp. 2.150.499.250,50 4 jam mempercepat waktu 90 hari dengan biaya Rp. 2.163.991.394,18.
مصداقية إعلام الطقس لدى الجمهور الأردني: إدارة الأرصاد الجوية وطقس العرب: دراسة مقارنة
Authors: Al-Hiyari Laith Muhammad Abdul Karim , Ali Oreqat Ahmad 
Published: August 2024

الأهداف: هدفت هذه الدراسة إلى تعرُّف مصداقية إعلام الطقس لدى الجمهور الأردني من خلال مقارنة دراسة إدارة الأرصاد الجوية وطقس العرب.
المنهجية: اتبعت الدراسة المنهج الوصفي مسح جمهور وسائل الإعلام، وتكونت عيذنة الدراسة المتاحة من 300 شخص من العاصمة عمان، حيثتم توزيع الاستبانة إلكترونيا من خلال صفحة الفيس بوك الخاصة بأمانة عمان الكبرى.
النتائج: إنّ ثقة الجمهور الأردني في إعلام الطقس سواء كانت من "طقس العرب" أو "إدارة الأرصاد الجوية" جاءت بدرجة متوسطة، وإن الجمهور الأردني يرى انّ "طقس العرب" أدقّ في تقديم توقعات الطقس مقارنةً بـ “إدارة الأرصاد الجوية"، حيث حصل "طقس العرب" على مستوى مرتفع في التقديرات، في حين أنّ تقييم "إدارة الأرصاد الجوية" كان على مستوى متوسط، وكما أظهرت النتائج أن الموضوعية في كل من "طقس العرب" و"إدارة الأرصاد الجوية" جاءتمتوسطة، وجاءت المصداقية لدى الجمهور الأردنيين في إعلام الطقس متوسطة.
التوصيات: يجب على وسائل الإعلام أن تجعل إعلام الطقس أكثر جاذبية وتطوير منصات متنوعة لتقديمة، مثل: التطبيقات المحمولة، والمواقع الإلكترونية، والوسائط الاجتماعية؛ وذلك لجذب جمهور أكبر، وتوسيع الشراكات بين مصادر الطقس المختلفة لتحسين دقّة وموضوعية الإعلام.
Persepsi Masyarakat Desa Sumberlesung, Ledokombo, Jember Tentang Makna Kemampuan Menikah dalam Hadits Nabi Muhammad s.a.w.
Authors: Mustofa Ach Dimyati 
Published: August 2024

Marriage is sunnatullah for the regeneration of Muhammad's people. There are many ways to carry out marriages by the Indonesian people, one of which is that the people of Sumberlesung Village understand the meaning of the ability to marry in the hadith of the Prophet Muhammad, which has implications for the practice of marriage. The perception of the meaning of being able to marry according to the community is first, living, alone, eating alone, thinking alone, second, ajegheh atenah reng seppo dua (maintaining the feelings of mother/father's heart), third, peace of mind, and as a community they say they must have jobs. The social culture is based on ancestors who were strengthened by religious leaders. In this study the authors focus on three aspects of the study; First, what is the perception of the people of Sumberlesung Village, Ledokombo, Jember about the meaning of the ability to marry in the hadith of the Prophet Muhammad. Second, what are the factors that cause the perception of the people of Sumberlesung Village, Ledokombo, Jember about the ability to marry in the hadith of the Prophet Muhammad. Third, what are the implications of the perception of the people of Sumberlesung Village, Ledokombo, Jember.
ANALISA KUALITAS JARINGAN 4G LTE DENGAN METODE DRIVE TEST PADA DAERAH URBAN DAN SUB URBAN
Authors: Andika Adik Putra 
Published: August 2024

Penelitian ini melakukan pengamatan kualitas jaringan menggunakan metode drive test dengan pengukuran menggunakan aplikasi yang sesuai dengan 4G LTE yaitu G-Net Track Pro. Pengukuran yang dilakukan adalah dengan metode drive test untuk mengukur kualitas sinyal 4G LTE menggunakan software G-Net Track Pro. Rute drive test pada penelitian ini daerah di Kabupaten Merauke, untuk urban di jalan Seringgu dan untuk sub urban di jalan Semangga. Proses pengambilan data dilakukan dengan metode drive test dan kemudian data akan terekam pada software G-Net Track Pro. Berdasarkan data hasil pengukuran parameter RSRP untuk jaringan 4G LTE Telkomsel pada kedua daerah tersebut, hasilnya menunjukkan bahwa untuk parameter RSRP daerah urban rata – rata nilainya adalah -74.89 dBm dengan kategori excellent. Sedangkan untuk parameter RSRP pada daerah sub urban rata – rata nilainya adalah -81.69 dBm dengan kategori good.