bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Necrosis Factor Receptor Type I Expression of CD4+ T Cells in Rheumatoid Arthritis Enables Them to Follow Tumor Necrosis Factor Gradients Into the Rheumatoid Synovium
Authors: Rossol Manuela , Schubert Kristin , Meusch Undine , Schulz Anett , Biedermann Bernd , Grosche Jens , Pierer Matthias , Scholz Roger , Baerwald Christoph , Thiel Andreas , Hagen Sebastian , Wagner Ulf 
Published: March 2013

ObjectiveThe cytokine tumor necrosis factor (TNF) plays a central role in the pathogenesis of rheumatoid arthritis (RA), but its disease‐specific effector mechanisms have not been fully elucidated. This study was undertaken to investigate the role of TNF in T cell accumulation and migration in the synovitic joints of RA patients.MethodsVital tissue sections from rheumatoid synovium were generated using a horizontally oscillating microtome and were coincubated with fluorescence‐labeled CD4+ T cells. Migration was detected by fluorescence and confocal microscopy. Migrating T cells were recovered from the tissue and analyzed for phenotype. Chemotaxis of CD4+ T cells from RA patients in response to increasing concentrations of TNF was analyzed in Transwell experiments.ResultsCD4+ T cells from RA patients migrated into the tissue sections in significantly higher numbers than T cells from healthy controls. Migrating CD4+ T cells differed from nonmigrating ones in their increased expression of TNF receptor type I (TNFRI), which was expressed on a fraction of circulating CD4+ T cells from RA patients, but not from controls. CD4+ T cells from the peripheral blood of RA patients were also found to migrate along TNF concentration gradients ex vivo. Accordingly, blockade of either TNF or TNFRI nearly abrogated in vitro T cell migration in synovial tissue.ConclusionOur findings indicate that the interaction of TNF with TNFRI is pivotal for T cell migration in synovial tissue in vitro, and thereby suggest a relevant role of the cytokine for in vivo T cell trafficking to synovitic joints.
Pharmacokinetic application of a bio‐analytical LC‐MS method developed for 5‐fluorouracil and methotrexate in mouse plasma, brain and urine
Authors: Ganti Vaishnavi , Walker Ellen A. , Nagar Swati 
Published: March 2013

ABSTRACTIn the past we have reported significant cognitive deficits in mice receiving 5‐fluorouracil in combination with low‐dose methotrexate. To explain such interactions, a pharmacokinetic study was designed. A sensitive bio‐analytical method was therefore developed and validated for 5‐fluorouracil and methotrexate in mouse plasma, brain and urine with liquid chromatography coupled to a single quadrupole mass spectrometer. Chromatographic separation was accomplished by Agilent® Zorbax® SB‐C18 column, with isocratic elution (5 mM ammonium acetate and methanol, 70:30, %v/v) at a flow rate of 300 μL/min. The limit of quantitation for both drugs was 15.6 ng/mL (plasma and brain) and 78.1 ng/mL (urine), with interday and intraday precision and accuracy ≤15% and a total run time of 6 min. This bio‐analytical method was used for the pharmacokinetic characterization of 5‐fluorouracil and methotrexate in mouse plasma, brain and urine over a period of 24 h. This method allowed characterization of the brain concentrations of 5‐fluorouracil over a period of 24 h. Copyright © 2013 John Wiley & Sons, Ltd.
Variability in the Essential‐Oil Composition of Sideritis scardicaGriseb. from Native Bulgarian Populations
Authors: Trendafilova Antoaneta B. , Todorova Milka N. , Evstatieva Ljuba N. , Antonova Daniela V. 
Published: March 2013

AbstractThe essential‐oil composition of six native populations of Sideritis scardica from Bulgaria was studied by GC‐FID and GC/MS analyses. Altogether, 37 components, representing 73.1 to 79.2% of the total oil content were identified. Among them, α‐pinene (4.4–25.1%), β‐pinene (2.8–18.0%), oct‐1‐en‐3‐ol (2.3–8.0%), phenylacetaldehyde (0.5–9.5%), β‐bisabolene (1.3–11.0%), benzyl benzoate (1.1–14.3%), and m‐camphorene (1; 0.3–12.4%) were the main compounds. All samples were characterized by low contents of oxygenated mono‐ and sesquiterpenes (≤1.6 and 2.3%, resp.). Principal component analysis (PCA) and cluster analysis (CA) showed a significant variability in the chemical composition of the studied samples as well as a correlation between the oil profiles and the ecological conditions of the natural habitats of S. scardica.
Antioxidative and Melanogenesis‐Inhibitory Activities of Caffeoylquinic Acids and Other Compounds from Moxa
Authors: Akihisa Toshihiro , Kawashima Kohta , Orido Masashi , Akazawa Hiroyuki , Matsumoto Masahiro , Yamamoto Ayako , Ogihara Eri , Fukatsu Makoto , Tokuda Harukuni , Fuji Jizaemon 
Published: March 2013

AbstractThe MeOH extract of moxa, the processed leaves of Artemisia princeps Pamp. (Asteraceae), exhibited potent 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical‐scavenging activity and melanogenesis‐inhibitory activity in α‐melanocyte‐stimulating hormone (α‐MSH)‐stimulated B16 melanoma cells. Eight caffeoylquinic acids, 1 and 6–12, five flavonoids, 13–17, two benzoic acid derivatives, 18 and 19, three coumarin derivatives, 20–22, four steroids, 23–26, and six triterpenoids, 27–32, were isolated from the MeOH extract. Upon evaluation of compounds 1, 6–23, and four semisynthetic caffeoylquinic acid esters, 2–5, for their DPPH radical‐scavenging activity, 15 compounds, 1–13, 17, and 19, showed potent activities (IC50 3.1–16.8 μM). The 15 compounds exhibited, moreover, potent inhibitory activities (51.1–92.5% inhibition) against peroxidation of linoleic acid emulsion at 10 μg/ml concentration. In addition, when 27 compounds, 1–8, 10, 12, 13, 15–18, 20–25, and 27–32, were evaluated for their inhibitory activity against melanogenesis in α‐MSH‐stimulated B16 melanoma cells, five caffeoylquinic acids, i.e., chlorogenic acid (1), ethyl chlorogenate (3), propyl chlorogenate (4), isopropyl chlorogenate (5), and butyl chlorogenate (6), along with homoorientin (17) and vanillic acid (18), exhibited inhibitory activities with 33–62% reduction of melanin content at 100 μM concentration with no or almost no toxicity to the cells (89–114% of cell viability at 100 μM). Western blot analysis showed that compound 6 reduced the protein levels of microphtalmia‐associated transcription factor (MITF), tyrosinase, tyrosine‐related protein 1 (TRP‐1), and TRP‐2 mostly in a concentration‐dependent manner, suggesting that this compound inhibits melanogenesis on α‐MSH‐stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase, TRP‐1, and TRP‐2. Furthermore, four compounds, 13, 15, 16, and 30, exhibited cytotoxicities against HL60 human leukemia cell line (IC50 7.0–11.1 μM), and nine compounds, 14–16, 23, 26–28, 31, and 32, showed inhibitory effects (IC50 272–382 mol ratio/32 pmol 12‐O‐tetradecanoylphohrbol‐13‐acetate (TPA)) against EpsteinBarr virus early antigen (EBV‐EA) activation induced by TPA in Raji cells.
A Peptide Nucleic Acid (PNA) Heteroduplex Probe Containing an Inosine–Cytosine Base Pair Discriminates a Single‐Nucleotide Difference in RNA
Authors: Matsumoto Katsuhiko , Nakata Eiji , Tamura Tomoki , Saito Isao , Aizawa Yasunori , Morii Takashi 
Published: March 2013

AbstractSelective discrimination of a single‐nucleotide difference in single‐stranded DNA or RNA remains a challenge with conventional DNA or RNA probes. A peptide nucleic acid (PNA)‐derived probe, in which PNA forms a pseudocomplementary heteroduplex with inosine‐containing DNA or RNA, effectively discriminates a single‐nucleotide difference in a closely related group of sequences of single‐stranded DNA and/or RNA. The pseudocomplementary PNA heteroduplex is easily converted to a fluorescent probe that distinctively detects a member of highly homologous let‐7 microRNAs.
ChemInform Abstract: Bismuth Flux Growth of CeRh6Ge4 and CeRh2Ge2 Single Crystals.
Authors: Vosswinkel Daniel , Niehaus Oliver , Rodewald Ute Ch. , Poettgen Rainer 
Published: March 2013

AbstractSingle crystals of the title compounds are grown from the elements in a bismuth flux (evacuated silica tube, 1320 K, 1 h).
ChemInform Abstract: New Facile Method for the Preparation of M3B7O13I Boracites (M: Mn, Fe, Co, Ni, Cd).
Authors: Wang Xiu‐Li , Huang Yi‐Zhi , Wu Li‐Ming 
Published: March 2013

AbstractThe title compounds are prepared from the corresponding transition metal oxides, B2O3, elemental boron, and I2 by a two‐crucible method (350—750 °C, 3 d, 70—95% yield).
ChemInform Abstract: Hydrophobic Core—Hydrophilic Shell‐Structured Catalysts: A General Strategy for Improving the Reaction Rate in Water.
Authors: Yang Hengquan , Jiao Xuan , Li Shuru 
Published: March 2013

AbstractA novel heterogeneous palladium catalyst featuring a structure of hydrophobic core — hydrophilic shell is prepared and successfully applied for the hydrogenation of different substrates in aqueous media.
ChemInform Abstract: A Polycomponent Metal‐Catalyzed Aliphatic, Allylic, and Benzylic Fluorination.
Authors: Bloom Steven , Pitts Cody Ross , Miller David Curtin , Haselton Nathan , Holl Maxwell Gargiulo , Urheim Ellen , Lectka Thomas 
Published: March 2013

AbstractThe selective incorporation of fluorine into organic molecules is achieved using Selectfluor in combination with a three‐component catalytic system.
ChemInform Abstract: Pd‐PEPPSI‐IPentCl: A Highly Effective Catalyst for the Selective Cross‐Coupling of Secondary Organozinc Reagents.
Authors: Pompeo Matthew , Froese Robert D. J. , Hadei Niloufar , Organ Michael G. 
Published: March 2013

AbstractAmong various catalysts tested, PES is found to be the most efficient one to couple allylzinc bromides and aryl halides with high selectivity for the branched product (III) in favor of the linear one.
ChemInform Abstract: Nickel‐Catalyzed Intermolecular [2 + 2] Cycloaddition of Conjugated Enynes with Alkenes.
Authors: Nishimura Akira , Ohashi Masato , Ogoshi Sensuke 
Published: March 2013

AbstractThe chemo‐ and regioselective cycloaddition of conjugated enynes with electron‐deficient as well as electronically neutral alkenes provides highly substituted cyclobutene derivatives.
ChemInform Abstract: Selective Access to Both Diastereoisomers in an Enantioselective Intramolecular Michael Reaction by Using a Single Chiral Organocatalyst and Application in the Formal Total Synthesis of (‐)‐Epibatidine.
Authors: Jensen Kim L. , Weise Christian F. , Dickmeiss Gustav , Morana Fabio , Davis Rebecca L. , Joergensen Karl Anker 
Published: March 2013

AbstractFrom organocatalytic intramolecular Michael addition reaction of nitro‐enones both diastereomers can be selectively obtained depending on the reaction conditions.
ChemInform Abstract: α‐Triethylsilyl‐α‐diazoacetone in Double Cross‐Aldolisation: Convenient Acetone Equivalent Toward 5‐Hydroxy‐1,3‐diketones.
Authors: Gosselin Pascal , et al. et al. 
Published: March 2013

AbstractAn original and convergent approach to the versatile 5‐hydroxy‐1,3‐diketone scaffold (VI) is described using α‐silyl‐α‐diazoketone (I) as synthetic equivalent of acetone.
ChemInform Abstract: Catalytic Aerobic Production of Imines en route to Mild, Green, and Concise Derivatizations of Amines.
Authors: Sonobe Toshiaki , Oisaki Kounosuke , Kanai Motomu 
Published: March 2013

AbstractThe present new oxidation method is applicable to a wide range of primary and secondary amines whereas, no reaction is observed for tertiary amines.
ChemInform Abstract: Ultrasound‐Promoted Sterically Congested Passerini Reactions under Solvent‐Free Conditions.
Authors: Cui Can , Zhu Cong , Du Xiu‐Jiang , Wang Zhi‐Peng , Li Zheng‐Ming , Zhao Wei‐Guang 
Published: March 2013

AbstractHigh‐power ultrasound is efficiently applied for the acceleration of solvent‐free Passerini reaction leading to α‐acyloxy amides (IV), (VIII) and (X).
ChemInform Abstract: Iron‐Facilitated Oxidative Dehydrogenative C—O Bond Formation by Propargylic Csp3—H Functionalization.
Authors: Wang Teng , Zhou Wang , Yin Hang , Ma Jun‐An , Jiao Ning 
Published: March 2013

AbstractTreatment of 1‐aryl‐3‐chloro‐1‐propynes with NaN3 generates intermediates whose azido function acts as an assisting group in C—H activation and facilitates the reaction with carboxylic acids.
ChemInform Abstract: An Unexpected Rearrangement—Hydration Reaction Sequence of 2H‐Chromenes to Dihydrochalcones under Catalysis of HAuCl4.
Authors: Maiti Gourhari , Kayal Utpal , Karmakar Rajiv , Bhattacharya Rudraksha N. 
Published: March 2013

AbstractA simple protocol is developed for the conversion of various substrates into highly functionalized propanone frameworks.
ChemInform Abstract: Catalytic Asymmetric Construction of Spiro(γ‐butyrolactam‐γ‐butyrolactone) Moieties Through Sequential Reactions of Cyclic Imino Esters with Morita—Baylis—Hillman Bromides.
Authors: Teng Huai‐Long , Huang He , Wang Chun‐Jiang 
Published: March 2013

AbstractThe first catalytic asymmetric preparation of the highly functionalized title compounds, valuable building blocks for drug discovery, is presented.
ChemInform Abstract: Trimethyl‐4‐oxo‐4,5,6,7‐tetrahydroindazole‐1‐acetic Acid: A New Lead Compound with Selective COX‐2 Inhibitory Activity.
Authors: Abdel‐Rahman Hamdy M. , Ozadali Keriman 
Published: March 2013

AbstractThe condensation of dimedone derivative (I) with ethyl hydrazinoacetate proceeds regioselectively.
ChemInform Abstract: Carbodiimides in the Synthesis of Enamino‐ and α‐Aminophosphonates as Peptidomimetics of Analgesic/Antiinflammatory and Anticancer Agents.
Authors: Abdou Wafaa M. , Barghash Reham F. , Bekheit Mohamed S. 
Published: March 2013

AbstractThe reactions of the highly unstable carbodiimide (III) with different phosphonates are studied and the activities of the products are evaluated.
ChemInform Abstract: Synthesis of Oxazoles Through Copper‐Mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines.
Authors: Xu Zejun , Zhang Chun , Jiao Ning 
Published: March 2013

AbstractThe procedure can be applied to various benzylic aldehydes and aliphatic or benzylic amines.
ChemInform Abstract: Desulfurization Strategy in the Construction of Azoles Possessing Additional Nitrogen, Oxygen or Sulfur Using a Copper(I) Catalyst.
Authors: Guin Srimanta , Rout Saroj Kumar , Gogoi Anupal , Nandi Shyamapada , Ghara Krishna Kanta , Patel Bhisma K. 
Published: March 2013

AbstractThis one‐pot tandem synthesis can be used to synthesize 5‐aminotetrazoles (III), 3‐amino[1,2,4]triazoles (VII), 2‐amino[1,3,4]oxadiazoles (X), and 2,5‐diamino[1,3,4]thiadiazoles (XII).
ChemInform Abstract: Design and Synthesis of Polycyclic Imidazole‐Containing N‐Heterocycles Based on C—H Activation/Cyclization Reactions.
Authors: Iaroshenko Viktor O. , Ostrovskyi Dmytro , Miliutina Mariia , Maalik Aneela , Villinger Alexander , Tolmachev Andrei , Volochnyuk Dmitriy M. , Langer Peter 
Published: March 2013

AbstractA wide range of imidazole‐containing N‐heterocycles is prepared via intramolecular C—H/C—Hal and C—H/C—H coupling reactions.
ChemInform Abstract: Nafion‐H®‐Catalyzed Synthesis of Polyhydroquinolines via the Hantzsch Multicomponent Reaction.
Authors: Kidwai Mazaahir , Chauhan Ritika , Bhatnagar Divya , Singh Abhay K. , Mishra Biswajit , Dey Sharmistha 
Published: March 2013

AbstractThe catalyst can be reused for four runs without loss of catalytic activity.
ChemInform Abstract: Synthesis and Biological Evaluation of Selective and Potent Cyclin‐Dependent Kinase Inhibitors.
Authors: N'gompaza‐Diarra Joannah , Bettayeb Karima , Gresh Nohad , Meijer Laurent , Oumata Nassima 
Published: March 2013

AbstractA substitution reaction between purine derivative (I) and chiral aminodiols leads to novel 2‐substituted purines such as (III), which are structurally related to the cyclin‐dependent kinase (CDK) inhibitor roscovitine.
ChemInform Abstract: Synthesis, Antimicrobial and Cytotoxicity Study of 1,3‐Disubstituted‐1H‐naphtho[1,2‐e][1,3]oxazines.
Authors: Verma Vikas , Singh Kuldeep , Kumar Devinder , Klapoetke Thomas M. , Stierstorfer Joerg , Narasimhan Balasubramanian , Qazi Asif Khurshid , Hamid Abid , Jaglan Sundeep 
Published: March 2013

AbstractA series of novel symmetrically (II) as well as unsymmetrically (VI) diaryl‐substituted 1H‐naphtho[1,2‐e][1,3]oxazines are synthesized and screened for their antimicrobial and cytotoxic activities.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Hydrogenation of N‐Hydroxy‐α‐imino Phosphonates Using Broensted Acid as Activator. The First Catalytic Enantioselective Approach to Chiral N‐Hydroxy‐α‐amino Phosphonates.
Authors: Goulioukina Nataliya S. , Shergold Ilya A. , Bondarenko Grigorii N. , Ilyin Mikhail M. , Davankov Vadim A. , Beletskaya Irina P. 
Published: March 2013

AbstractThis is the first catalytic, most straightforward, and atom‐economical approach to enantioenriched N‐hydroxy‐α‐amino‐phosphonates (II).
ChemInform Abstract: 3‐P=O‐Functionalized Phospholane 1‐Oxides by the Michael Reaction of 1‐Phenyl‐2‐phospholene 1‐Oxide and Dialkyl Phosphites, H‐Phosphinates, or Diphenylphosphine Oxide.
Authors: Jablonkai Erzsebet , Drahos Laszlo , Drzazga Zbigniew , Pietrusiewicz K. Michal , Keglevich Gyoergy 
Published: March 2013

AbstractThe reaction proceeds better under conventional conditions.
ChemInform Abstract: 4‐Organochalcogenoyl‐1H‐1,2,3‐triazoles: Synthesis and Functionalization by a Nickel‐Catalyzed Negishi Cross‐Coupling Reaction.
Authors: Stefani Helio A. , Leal Daiana M. , Manarin Flavia 
Published: March 2013

AbstractThe click chemistry concept gives rise to formation of organoselenium‐ and organotelluriumtriazoles (III) and (V) in moderate to good yields via 1,3‐dipolar cycloaddition employing organochalcogen acetylenes (I) and (IV).
ChemInform Abstract: Organocatalytic Tandem Michael Addition Reactions: A Powerful Access to the Enantioselective Synthesis of Functionalized Chromenes, Thiochromenes and 1,2‐Dihydroquinolines
Authors: Bhanja Chittaranjan , Jena Satyaban , Nayak Sabita , Mohapatra Seetaram 
Published: March 2013

AbstractReview: 77 refs.
3,4‐Dinitrobenzamide Functionalized CdTe/ZnTe Quantum Dots as a Nanoprobe for Imaging Glutathione S‐Transferase in Living Cells
Authors: Lu Jinxin , Song Yanchao , Shi Wen , Li Xiaohua , Ma Huimin 
Published: March 2013

AbstractA novel fluorescent nanoprobe for glutathione S‐transferase (GST) has been developed by incorporating 3,4‐dinitrobenzamide (a specific substrate of GST) onto CdTe/ZnTe quantum dots. The probe itself displays a low background signal due to the strong quenching effect of the electron‐withdrawing unit of 3,4‐dinitrobenzamide on the quantum dots. However, GST can efficiently catalyze the nucleophilic substitution of reduced glutathione on the p‐nitro group of the nanoprobe, leading to a large fluorescence enhancement. Most notably, this enhancement shows high selectivity and sensitivity towards GST instead of the other biological substances. With this nanoprobe, a simple fluorescence imaging method for intracellular GST has been established, and its applicability has been successfully demonstrated for imaging GST in different living cells, which reveals that A549 cells express GST about 3 times higher than NIH‐3T3 and Hela cells.
Chromatic adaptation by illuminant matrix products: An alternative to sharpened von kries primaries
Authors: Brill Michael H. , Oleari Claudio 
Published: March 2013

AbstractPrevious attempts to predict chromatic‐adaptation correspondence have led to a sharpening dilemma—i.e., Von Kries primaries are chosen that do not include in the positive octant all the realizable (x,y) chromaticities. This leads to paradoxical adaptation predictions for the colors that have negative Von Kries coordinates. A solution is proposed here that expresses the asymmetric‐matching relation of chromatic adaptation as the product of two matrix transformations, given source illuminant 1 and destination illuminant 2: from source tristimulus values via adaptation matrix 1 to the adapted state coordinates, and from the adapted state via the inverse of adaptation matrix 2 to the destination illuminant tristimulus values. To avoid the sharpening instability, the entire spectrum locus must lie within the positive octant of the adapted state tristimulus space. © 2013 Wiley Periodicals, Inc. Col Res Appl, 39, 275–278, 2014; Published Online 14 March 2013 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/col.21799
An open‐channel flume study of flow characteristics through a combined layer of submerged and emerged flexible vegetation
Authors: Li Yiping , Anim Desmond Ofosu , Wang Ying , Tang Chunyan , Du Wei , Yu Zhongbo , Acharya Kumud 
Published: March 2013

ABSTRACTFlowing water bodies often have plants that differ greatly in size and type, which interfere with fluid flow structure. Although there are studies describing vegetation–flow interactions in ideal laboratory conditions, their practical application is sometimes still difficult. This paper presents results of research involving laboratory simulations channel flow and the effects upon its structure as it passes through a combined layer of submerged and emerged vegetation in an open‐channel flume. Instantaneous time‐average velocity and turbulence at various locations were measured with a 3D acoustic Doppler velocimeter. The experimental results showed that the mean velocity profiles can be divided into three layers: bottom, middle and upper. The velocity profiles show the flow structure was complex variable over time creating mixing velocity layers associated with inflection points and velocity spikes. Turbulence intensity urms, vrms, wrms was nearly invariant for the flow depth at the bottom layer in most locations within the vegetation area. Maximum turbulence intensity occurred within the middle layer and migrated vertically as frontal width of the plant increased. Maximum turbulence intensity fluctuated at the velocity mixing layer where there is significant momentum exchange. The Manning's vegetation roughness coefficient n(v) due to vegetation resistance increased with vegetation density as expected. In all, the results show flow structure varies substantially at the stem section and at the canopy top of submerged vegetation. These analytical findings will be useful in understanding river channel hydraulic transport and mixing processes and useful in river engineering applications and modelling. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis of Functionalized Core–Shell CdTe/ZnS Nanoparticles and Their Application as a Fluorescence Probe for Norfloxacin Determination
Authors: Li Li , Cheng Yu , Ding Yaping , Gu Shuqing , Zhang Fenfen , Yu Weijun 
Published: March 2013

AbstractA novel and simple fluorometry method has been developed and validated for the determination of norfloxacin (NOR) on the basis of the fluorescence quenching of thioglycolic acid (TGA)‐capped CdTe/ZnS nanoparticles (NPs) by NOR. The functionalized CdTe/ZnS NPs were successfully synthesized in aqueous medium with TGA as the capping ligand. TGA‐capped CdTe/ZnS NPs were characterized by using X‐ray diffraction (XRD), transmission electron microscopy (TEM), particle size measurements, and Fourier transform infrared (FTIR) spectroscopy. Owing to a specific interaction, the fluorescence intensity of CdTe/ZnS NPs is clearly reduced in the presence of NOR. Under optimal conditions, the relative fluorescence intensity of CdTe/ZnS NPs is linearly proportional to NOR concentration from 0.2 to 140 μM with a detection limit of 0.082 μM. This probe was also successfully utilized to determine the NOR in pharmaceutical formations. The quenching mechanism was also investigated. The proposed method is simple, rapid, and practical.