bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional and new trend strategies to enhance pigment contents in microalgae
Authors: Aizpuru Aitor , González-Sánchez Armando 
Published: July 2024

AbstractMicroalgae are a source of a wide variety of commodities, including particularly valuable pigments. The typical pigments present in microalgae are the chlorophylls, carotenoids, and phycobiliproteins. However, other types of pigments, of the family of water-soluble polyphenols, usually encountered in terrestrial plants, have been recently reported in microalgae. Among such microalgal polyphenols, many flavonoids have a yellowish hue, and are used as natural textile dyes. Besides being used as natural colorants, for example in the food or cosmetic industry, microalgal pigments also possess many bioactive properties, making them functional as nutraceutical or pharmaceutical agents. Each type of pigment, with its own chemical structure, fulfills particular biological functions. Considering both eukaryotes and prokaryotes, some species within the four most promising microalgae groups (Cyanobacteria, Rhodophyta, Chlorophyta and Heterokontophyta) are distinguished by their high contents of specific added-value pigments. To further enhance microalgae pigment contents during autotrophic cultivation, a review is made of the main related strategies adopted during the last decade, including light adjustments (quantity and quality, and the duration of the photoperiod cycle), and regard to mineral medium characteristics (salinity, nutrients concentrations, presence of inductive chemicals). In contrast to what is usually observed for growth-related pigments, accumulation of non-photosynthetic pigments (polyphenols and secondary carotenoids) requires particularly stressful conditions. Finally, pigment enrichment is also made possible with two new cutting-edge technologies, via the application of metallic nanoparticles or magnetic fields.
Integrating machine learning and geospatial data analysis for comprehensive flood hazard assessment
Authors: Singha Chiranjit , Rana Vikas Kumar , Pham Quoc Bao , Nguyen Duc C. , Łupikasza Ewa 
Published: July 2024

AbstractFlooding is a major natural hazard worldwide, causing catastrophic damage to communities and infrastructure. Due to climate change exacerbating extreme weather events robust flood hazard modeling is crucial to support disaster resilience and adaptation. This study uses multi-sourced geospatial datasets to develop an advanced machine learning framework for flood hazard assessment in the Arambag region of West Bengal, India. The flood inventory was constructed through Sentinel-1 SAR analysis and global flood databases. Fifteen flood conditioning factors related to topography, land cover, soil, rainfall, proximity, and demographics were incorporated. Rigorous training and testing of diverse machine learning models, including RF, AdaBoost, rFerns, XGB, DeepBoost, GBM, SDA, BAM, monmlp, and MARS algorithms, were undertaken for categorical flood hazard mapping. Model optimization was achieved through statistical feature selection techniques. Accuracy metrics and advanced model interpretability methods like SHAP and Boruta were implemented to evaluate predictive performance. According to the area under the receiver operating characteristic curve (AUC), the prediction accuracy of the models performed was around > 80%. RF achieves an AUC of 0.847 at resampling factor 5, indicating strong discriminative performance. AdaBoost also consistently exhibits good discriminative ability, with AUC values of 0.839 at resampling factor 10. Boruta and SHAP analysis indicated precipitation and elevation as factors most significantly contributing to flood hazard assessment in the study area. Most of the machine learning models pointed out southern portions of the study area as highly susceptible areas. On average, from 17.2 to 18.6% of the study area is highly susceptible to flood hazards. In the feature selection analysis, various nature-inspired algorithms identified the selected input parameters for flood hazard assessment, i.e., elevation, precipitation, distance to rivers, TWI, geomorphology, lithology, TRI, slope, soil type, curvature, NDVI, distance to roads, and gMIS. As per the Boruta and SHAP analyses, it was found that elevation, precipitation, and distance to rivers play the most crucial roles in the decision-making process for flood hazard assessment. The results indicated that the majority of the building footprints (15.27%) are at high and very high risk, followed by those at very low risk (43.80%), low risk (24.30%), and moderate risk (16.63%). Similarly, the cropland area affected by flooding in this region is categorized into five risk classes: very high (16.85%), high (17.28%), moderate (16.07%), low (16.51%), and very low (33.29%). However, this interdisciplinary study contributes significantly towards hydraulic and hydrological modeling for flood hazard management.
Where have all the flowers gone? A systematic evaluation of factors driving native terrestrial plant decline in North America
Authors: Prosser Ryan S. , Brain Richard A. 
Published: July 2024

AbstractPrior to the arrival of Europeans in North America, forest and grasslands individually covered a 3rd of the conterminous United States; however, following the colonial and pioneer periods, respectively, these land cover categories were reduced to 70% and 50% of their original prominence. The dominant driving force for native land conversion was agriculture, which expanded exponentially from the Atlantic to the Pacific, comprising over half the total land area of America at its peak in 1950. However, farmland area has subsequently declined by 25%, so what has been driving native plant declines north of the 30th latitudinal parallel over the past 75 years? Analysis of recovery plans issued by the U.S. Fish and Wildlife Service indicates that of the over 900 plant species “listed” as threatened and endangered the primary driver of decline was invasive species, followed by habitat alteration, and development, which collectively accounted for 93.2% of the primary drivers for listed species. In Canada, these three drivers of decline were the primary drivers for 81% of listed species. Comparatively, herbicides were identified as the primary or secondary driver in 13 out of 1124 cases (1.2%). Given that agricultural land area is contracting in the U.S. and Canada, there appears to be a misconception that agrochemicals are the seminal cause of native plant decline. Here, we explore the individual contribution of drivers relative to the historical events of North America to provide context and perspective as well as focus and prioritize conservation efforts accordingly.
Linking teachers’ and students’ motivation for self-regulated learning: is there a signal and how is it transmitted?
Authors: Jud Johannes , Karlen Yves , Hirt Carmen Nadja 
Published: July 2024

AbstractTeachers’ motivation is a core professional competence that influences their choices in their decision-making, such as promoting self-regulated learning (SRL). Promoting SRL supports students’ SRL development and might affect students’ motivation to apply strategies. However, the link between teachers’ motivation to promote SRL and students’ motivation to apply strategies has yet to be empirically investigated. In a multilevel analysis that included 167 lower secondary teachers and their 2,785 students, we analysed the direct and indirect relationships between teachers’ self-efficacy and attainment value, the teacher- and student-reported SRL promotion and students’ self-efficacy, utility value, attainment value and cost at the class and individual level. Additionally, we investigated the contribution of teacher- and student-reported SRL promotion to find indirect relations. Teachers’ self-efficacy was related to teacher-reported SRL promotion, and student-reported SRL promotion was associated with all motivational outcomes at the class and student level except for cost. Further, we found indirect effects between teachers’ self-efficacy for SRL promotion and students’ values and self-efficacy for SRL via teachers- and students-perceived SRL promotion. No direct effects between teacher and student motivation could be found, and no significant indirect relationships were found for the cost aspect. Regarding how the signal is transmitted, the results show that including student reports of SRL promotion is especially crucial to finding indirect links. However, future studies should employ longitudinal designs and incorporate more nuanced teacher and student motivation measures in SRL to better understand the motivational links between teachers and students.
Elevated Carbon Dioxide only Partly Alleviates the Negative Effects of Elevated Temperature on Potato Growth and Tuber Yield
Authors: Kiongo S. C. , Taylor N. J. , Franke A. C. , Steyn J. M. 
Published: July 2024

AbstractThe current rapid increase in ambient carbon dioxide concentration ([CO2]) and global temperatures have major impacts on the growth and yield of crops. Potato is classified as a heat-sensitive temperate crop and its growth and yield are expected to be negatively affected by rising temperatures, but it is also expected to respond positively to increasing ambient [CO2]. In this study, we investigated the physiological, growth, and yield responses of two potato cultivars to elevated temperature (eT) and the possible role of elevated [CO2] (e[CO2]) in counteracting the negative effects of eT. Two growth chamber trials (trials 1 and 2) were conducted using two temperature regimes: ambient temperature (aT, Tmin/Tmax = 12/25 ℃) and eT (Tmin/Tmax = 15/38 ℃), and two [CO2]: ambient (a[CO2]) = 415 ppm and e[CO2] = 700 ppm. Temperatures gradually rose from the minimum at 6.00 AM to reach Tmax at noon, then Tmax was maintained for 1 h in trial 1 and for 4 h in trial 2. Elevated [CO2] increased photosynthesis (Anet) in both cultivars at aT and eT. Elevated temperature also stimulated Anet compared to aT. Elevated [CO2] significantly reduced stomatal opening size, while eT resulted in larger stomata openings and higher stomatal conductance. Elevated [CO2] increased tuber yields at aT in both trials. Tuberisation was delayed by eT in trial 1, and completely inhibited in trial 2 even at e[CO2], resulting in no tuber yield. The two cultivars responded similarly to treatments, but Mondial initiated more tubers and had higher tuber yield than BP1. The results suggest that potato will benefit from e[CO2] in future, even when exposed to high Tmax for a short period of the day, but the benefit will be eroded when the crop is exposed to high Tmax for an extended period of the day.
Models of survivorship care in patients with head and neck cancer in regional, rural, and remote areas: a systematic review
Authors: Pradhan Poorva , Sharman Ashleigh R. , Palme Carsten E. , Elliott Michael S. , Clark Jonathan R. , Venchiarutti Rebecca L. 
Published: July 2024

Abstract
Purpose
Rural people with head and neck cancers (HNC) are likely to experience poorer health outcomes due to limited access to health services, so many benefit from models of care that account for rurality. The aim of this review was to synthesise literature on models of care in this population.

Methods
Studies were identified using seven databases: PubMed, PsycINFO, Scopus, Embase, CINAHL, Medline, and Web of Science. Studies that tested or reported a model of care in rural HNC survivors were included. Data on characteristics and outcomes of the models were synthesised according to the domains in the Cancer Survivorship Care Quality Framework, and study quality was appraised.

Results
Seventeen articles were included. Eight were randomised controlled trials (seven with a control group and one single-arm study). Three models were delivered online, nine via telehealth, and five in-person. Majority were led by nurses and allied health specialists and most addressed management of physical (n = 9) and psychosocial effects (n = 6), while only a few assessed implementation outcomes such as cost-effectiveness. None evaluated the management of chronic health conditions.

Conclusion
Positive outcomes were reported for domains of survivorship care that were measured; however, further evaluation of models of care for rural people with HNC is needed to assess effectiveness across all domains of care.

Implications for Cancer Survivors
Rural cancer survivors are a diverse population with unique needs. Alternative models of care such as shared care, or models personalised to the individual, could be considered to reduce disparities in access to care and outcomes.
Meanders of Vilém Flusser’s Ethics of Alterity
Authors: Dias da Silva Wanderley 
Published: July 2024

AbstractThe article considers the central place the ideas of transcension and affective responsibility play in the thought of the Czech-Brazilian philosopher Vilém Flusser. From this, it outlines some of the intricacies of what can be termed a typically Flusserian ethics of alterity. In the process, it will be revealed that all of this leads Flusser curiously back to Hegel. The return to Hegel indicates, among other things, that any attempt to philosophize about the experience of otherness seems always to give the Swabian philosopher the last word.
Are BTEX (Benzene, Toluene, Ethylbenzene and Xylenes) involved in the development of amyotrophic lateral sclerosis?
Authors: Santurtún Ana , Fdez-Arroyabe Pablo , Sedano Maria José , Delgado-Alvarado Manuel , Almendra Ricardo , Riancho Javier 
Published: July 2024

AbstractAir pollution is an environmental factor involved in neuroinflammation, which leads to the progressive neuronal damage that appears in various neurodegenerative diseases. This article reviews the impact on Amyotrophic Lateral Sclerosis (ALS), the most common degenerative motor neuron disease, of exposure to BTEX (benzene, toluene, ethylbenzene, and xylene), aromatic hydrocarbons capable of crossing the blood-brain barrier, with documented neurotoxic effects. Results show that occupational exposure to BTEX has been linked to the incidence of ALS, while the relationship with the exposure in residential environments with high levels of these toxins in outdoor air is not conclusive; sources of BTEX emissions often lead to mixed toxic exposure, making it challenging to assess the specific impact of this group of pollutants. Under the commonly accepted hypothesis that ALS is a disease triggered by the accumulation of multiple steps, BTEX could be the step causing toxic insult, or alternatively, BTEX might play a role in the disease’s progression. However new studies are necessary to determine its involvement in the disease.
Leveraging Cell Migration Dynamics to Discriminate Between Senescent and Presenescent Human Mesenchymal Stem Cells
Authors: Amiri Farshad , Mistriotis Panagiotis 
Published: July 2024

Abstract
Purpose
The suboptimal clinical performance of human mesenchymal stem cells (hMSCs) has raised concerns about their therapeutic potential. One major contributing factor to this issue is the heterogeneous nature of hMSCs. Senescent cell accumulation during stem cell expansion is a key driver of MSC heterogeneity. Current methodologies to eradicate senescent hMSCs have either shown limited success or lack clinical relevance. This study leverages the inherent capacity of hMSCs to migrate toward damaged tissues as a means to discern senescent from presenescent stem cells. Given the established deficiency of senescent cells to migrate through physiologically relevant environments, we hypothesized that a microfluidic device, designed to emulate key facets of in vivo cell motility, could serve as a platform for identifying presenescent cells.

Methods
We employed a Y-shaped microchannel assay, which allows fine-tuning of fluid flow rates and the degree of confinement.

Results
Highly migratory hMSCs detected by the device not only demonstrate increased speed, smaller size, and higher proliferative capacity but also manifest reduced DNA damage and senescence compared to non-migratory cells. Additionally, this assay detects presenescent cells in experiments with mixed early and late passage cells. The introduction of fluid flow through the device can further increase the fraction of highly motile stem cells, improving the assay's effectiveness to remove senescent hMSCs.

Conclusions
Collectively, this assay facilitates the detection and isolation of a highly potent stem cell subpopulation. Given the positive correlation between the migratory potential of administered MSCs and the long-term clinical outcome, delivering homogeneous, highly motile presenescent hMSCs may benefit patient outcomes.
Molecular representations in bio-cheminformatics
Authors: Nguyen-Vo Thanh-Hoang , Teesdale-Spittle Paul , Harvey Joanne E. , Nguyen Binh P. 
Published: July 2024

AbstractMolecular representations have essential roles in bio-cheminformatics as they facilitate the growth of machine learning applications in numerous sub-domains of biology and chemistry, especially drug discovery. These representations transform the structural and chemical information of molecules into machine-readable formats that can be efficiently processed by computer programs. In this paper, we present a comprehensive review, providing readers with diverse perspectives on the strengths and weaknesses of well-known molecular representations, along with their respective categories and implementation sources. Moreover, we provide a summary of the applicability of these representations in de novo molecular design, molecular property prediction, and chemical reactions. Besides, representations for macromolecules are discussed with highlighted pros and cons. By addressing these aspects, we aim to offer a valuable resource on the significant role of molecular representations in advancing bio-cheminformatics and its related domains.
Modelling land and water based movement corridors in the Western Mediterranean: a least cost path analysis from chalcolithic and early bronze age ivory records
Authors: Bilotti Giacomo , Kempf Michael , Morillo Leon Jose Miguel 
Published: July 2024

AbstractThe transportation of Chalcolithic and Early Bronze Age ivory raw materials and artefacts across the Mediterranean has been in the focus of archaeological research for over a century now. However, tracing the flow of ivory has mostly been restricted to traditional theoretical models of raw materials distribution deriving from socio-culturally centred considerations. Environmental conditions, potential transportation networks and dissemination routes have not yet been considered decisive for the spread of ivory raw material from the African shores and the eastern Mediterranean towards the Iberian Peninsula. Implementing computational environmental and archaeological modelling, we present a fully reproducible quantitative approach to estimate potential communication and transportation networks based on environmental covariates. We deploy a Network Analysis model and a predictive model based on Least Cost Path density to propose a potential land- and sea-based movement corridor for the western Mediterranean Basin that could have enabled the cultural spread of resources during the 3rd and 2nd millennia BC. Using the presented model and the open-source data underlying the analyses, distribution patterns of multiple material resources from different chronological subsets or regions can be developed, which will contribute to understanding prehistoric human patterns across the Mediterranean.
American Entrepreneur 1990–2010: Black Business Ownership as a Path Way Out of Poverty & Violence
Authors: Parker Karen F. , Gray Andrew C. 
Published: July 2024

AbstractEntrepreneurship is touted as a pathway to achieve economic mobility and this is particularly true among immigrants and Black Americans. There is little research on whether the rise in Black entrepreneuership is linked to the declining rates of violernce in urban areas, net of effects associated with the concentration of disadvantage. After generating two distinct measures of Black entrepreneurship using national-level business ownership data, we test to see if Black-owned businesses were significantly related to the documented decline in juvenile violence in larger US cities from 1990 to 2010. Our findings show an inverse relationship between Black entrepreneurship and youth violence across multiple cities in 1990 and 2000, while the rate of paid employees in Black firms contributed to a reduction of Black youth violence in 2010. Furthermore, our fixed-effect design confirms the growing presence of Black businesses is a significant contributor to the reduction in Black urban violence. In changing economic times, we discuss the theoretical and empirical importance of Black entrepreneurship as a way out of poverty and crime in urban areas.
Geospatial based groundwater resources susceptibility and contamination risk mapping for Yeşilköy aquifer, Cyprus
Authors: İpek Cem , Türker Umut 
Published: July 2024

AbstractIn rural areas where the goals of sustainable agriculture are intertwined with the availability and supply of groundwater resources, it becomes imperative to perceive and search the status of groundwater resource’s susceptibility to contamination. A well-known overlay & index method, the DRASTIC model that assesses the state of susceptibility to contamination using vulnerability index map has been applied to the Yeşilköy aquifer. The seven different hydro-geologic parameters; aquifer media, vadose zone, and soil media, surface topography, recharge capacity, water table depth, and the hydraulic conductivity maps were overlaid to find the vulnerability of the aquifer. Results depicted that the aquifer is categorized into two vulnerability zones; low and moderate. The available susceptibility of the aquifer due to ongoing anthropogenic activities like agriculture was also studied by implementing the Weighted Arithmetic Water Quality Index (WQI) method. The aquifer’s overall water quality was “poor water quality”. Hence, there was no significant relationship between WQI and the vulnerability of the aquifer. A modification of the DRASTIC to enhance the relationship with WQI is proposed by utilizing the Analytic Hierarchy Process (AHP), as one of the successful multi-criteria decision-making models. The modification of the DRASTIC model with AHP revealed that the performance of the DRASTIC model was improved and the correlation between WQI and the DRASTIC vulnerability index was significantly enhanced. The results also show that the effective contributing parameters for groundwater vulnerability in the Yeşilköy aquifer were the aquifer media and the vadose zone. On the other hand, the water table’s depth and topography were almost independent of the aquifer’s vulnerability.
The roles of FGFR3 and c-MYC in urothelial bladder cancer
Authors: Bogale Dereje E. 
Published: July 2024

AbstractBladder cancer is one of the most frequently occurring cancers worldwide. At diagnosis, 75% of urothelial bladder cancer cases have non-muscle invasive bladder cancer while 25% have muscle invasive or metastatic disease. Aberrantly activated fibroblast growth factor receptor (FGFR)-3 has been implicated in the pathogenesis of bladder cancer. Activating mutations of FGFR3 are observed in around 70% of NMIBC cases and ~ 15% of MIBCs. Activated FGFR3 leads to ligand-independent receptor dimerization and activation of downstream signaling pathways that promote cell proliferation and survival. FGFR3 is an important therapeutic target in bladder cancer, and clinical studies have shown the benefit of FGFR inhibitors in a subset of bladder cancer patients. c-MYC is a well-known major driver of carcinogenesis and is one of the most commonly deregulated oncogenes identified in human cancers. Studies have shown that the antitumor effects of FGFR inhibition in FGFR3 dependent bladder cancer cells and other FGFR dependent cancers may be mediated through c-MYC, a key downstream effector of activated FGFR that is involved tumorigenesis. This review will summarize the current general understanding of FGFR signaling and MYC alterations in cancer, and the role of FGFR3 and MYC dysregulation in the pathogenesis of urothelial bladder cancer with the possible therapeutic implications.