bluuebunny/crossref_metadata_2025_split huggingface dataset:
A MOF@MOF S‐scheme Heterojunction with Lewis Acid‐Base Sites Synergistically Boosts Cocatalyst‐Free CO2 Cycloaddition
Authors: Shen Qiuyan , Chen Weiren , Wang Min , Jin Xixiong , Zhang Lingxia , Shi Jianlin 
Published: August 2024

AbstractThe photocatalytic cycloaddition reaction between CO2 and epoxide is one of the most promising green routes for CO2 utilization, for which high performance photocatalysts are intensely desired. Herein, we have constructed an S‐scheme heterojunction of MIL‐125@ZIF‐67 modified by amino groups, which achieves a cyclic carbonate yield of as high as 99 % without employing any co‐catalyst, outperforming the previously reported photocatalysts. In‐situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and in‐situ electron paramagnetic resonance (EPR) spectroscopy reveal the important role of photogenerated electron migration from Lewis acid (Co) sites to the O atom of epoxide in triggering its ring‐opening (the rate‐determining step of CO2 cycloaddition reaction) under the assistance of photogenerated hole. Synergistically and concurrently, the Lewis base (amino groups) sites activate CO2 to CO2*, facilitating the following CO2 cycloaddition. Such a synergistic effect provides a most favorable approach to design efficient heterogeneous photocatalysts with dual/multiple‐active sites for CO2 cycloaddition reaction.
Under the mantra: ‘Make use of colorblind friendly graphs’
Authors: Rocchini Duccio , Chieffallo Ludovico , Thouverai Elisa , D'Introno Rossella , Dagostin Francesca , Donini Emma , Foody Giles , Garnier Simon , Mazzochini Guilherme G. , Moudry Vitezslav , Rudis Bob , Simova Petra , Torresani Michele , Nowosad Jakub 
Published: August 2024

AbstractColorblindness is a genetic condition that affects a person's ability to accurately perceive colors. Several papers still exist making use of rainbow colors palette to show output. In such cases, for colorblind people such graphs are meaningless. In this paper, we propose good practices and coding solutions developed in the R Free and Open Source Software to (i) simulate colorblindness, (ii) develop colorblind friendly color palettes and (iii) provide the tools for converting a noncolorblind friendly graph into a new image with improved colors.
Problem Adaptation Therapy (PATH) to Treat Depression in Older Adults With Cognitive Impairment: A Systematic Review of Treatment Effects
Authors: Collyer Sarah , Dorstyn Diana 
Published: August 2024

ABSTRACTObjectivesProblem adaptation therapy (PATH) is a relatively new psychotherapy that recognises the importance of simultaneously targeting cognitive impairment and functional disability in the treatment of late‐life depression. This is the first systematic review to examine the effectiveness of PATH.MethodsAgeline, Embase, Medline, PsycINFO, Scopus and ProQuest databases were searched from 2010 until 5 April 2024, for studies that evaluated PATH for older people. Where possible, effect sizes (Hedges' g) with 95% confidence intervals and p values were calculated and pooled using a random effects model. The reporting quality of included studies was assessed using Joanna Briggs Institute Critical Appraisal tools and certainty of the evidence behind each result assessed with The Grading of Recommendations Assessment, Development and Evaluation method.ResultsTwelve papers, from seven independent studies and a pooled sample of 579 older adults with multiple comorbidities, were included in this review. PATH participants experienced immediate reductions in depression symptom ratings (gw = 0.72, p < 0.01, Nstudies = 5), alongside small improvements in disability (gw = 0.61, p = 0.04, Nstudies = 4) compared to peers that received supportive therapy, brief psychoeducation, or usual care. The overall evidence quality was, however, characterised by bias, inconsistency, and imprecision in effect estimates. Positive participant feedback and low dropout rates (15%–31%) suggested treatment satisfaction, although these data were not routinely provided.ConclusionsPATH may be a viable treatment for older people living with mental and cognitive disorders, however there is a need for more rigorous research incorporating follow‐up assessments to consolidate the effectiveness of PATH relative to other treatments. Incorporating measures of treatment fidelity are also critical to interpreting and generalising these data. The protocol for this study was prospectively published on the Open Science Framework (https://osf.io/gx57a).
Perceived internal corporate social responsibility and employees' proactive behavior: The mediating role of intentions to start personal projects and the moderating role of perceived external prestige
Authors: López Aníbal , Costa Sandra 
Published: August 2024

AbstractThis study deepens our understanding of the micro‐level processes underlying the relationship between employees' internal corporate social responsibility (CSR) perceptions (perceived internal CSR) and their proactive behavior. Drawing on the self‐regulation and social information processing perspectives, we propose that perceived internal CSR enacts employees' intentions to start personal projects within the organization. We contend that this relationship is contingent upon employees' perceptions of the external prestige of the organization. Additionally, we argue that this interplay influences employees' proactive behavior, specifically innovative and risk‐taking actions. Employing a multimethod approach, comprising a multisource field study involving 640 employee‐supervisor dyads and a two‐by‐two experimental design with 152 respondents, our findings demonstrate a positive association between perceived internal CSR and employees' intentions to start personal projects. This effect is stronger when employees perceive the organization as highly prestigious. As predicted, this interaction positively influences innovative and risk‐taking behaviors. This research provides valuable insights into the nuanced dynamics between internal CSR and proactive behavior, offering implications for scholars and practitioners in human resource development.
The influential responsibility of sirtuins in senescence and associated diseases: A review
Authors: Mishra Deepak , Mohapatra Lucy , Tripathi Alok S. , Paswan Shravan Kumar 
Published: August 2024

AbstractAging is a process of time‐associated depletion in the physiological functions, essential for the survival and reproducibility of living beings. Some age‐related disorders can be successfully controlled with some biomedical techniques or pharmaceutical approaches. There are some precise remedies that demonstrate conspicuous promise in the preclinical and clinical setup of extending lifespan or enhancing health by altering natural senescence. The sirtuin family of proteins is one of the most favorable targets for antiaging strategies. Sirtuins were initially identified as transcription repressors in yeast, but today they are known to exist in bacteria and eukaryotes, as well as humans. The SIRT (1–7) family of proteins in humans is made up of seven members, each of which has either mono‐ADP ribosyl transferase or deacetylase activity. Researchers suggest that sirtuins are essential for cell metabolism and play a major role in how cells react to various stimuli, such as oxidative or genotoxic stress. A healthy lifestyle, which includes exercise and a balanced diet, has been demonstrated to impact health span by adjusting the levels of sirtuins, suggesting the involvement of sirtuins in extending human longevity. The hunt for sirtuin activators is among the most extensive and comprehensive research subjects in the present scenario. Some optimism has been generated to investigate antiaging therapies by natural compounds, such as curcumin and others. This review article highlights the role of sirtuins in native senescence and their primordial roles in the progression of several life‐threatening diseases. Further, it also provides recent information on the sirtuin activators and inhibitors and their therapeutic benefits.
Mutant NPM1 marginally impacts ribosome footprint in acute myeloid leukemia cells
Authors: Brunetti Lorenzo , Pianigiani Giulia , Gundry Michael C. , Goodell Margaret A. , Falini Brunangelo 
Published: August 2024

AbstractBackgroundNPM1‐mutated acute myeloid leukemia (AML) is the most frequent AML subtype. As wild‐type NPM1 is known to orchestrate ribosome biogenesis, it has been hypothesized that altered translation may contribute to leukemogenesis and leukemia maintenance in NPM1‐mutated AML. However, this hypothesis has never been investigated. We reasoned that if mutant NPM1 (NPM1c) directly impacts translation in leukemic cells, loss of NPM1c would result in acute changes in the ribosome footprint.MethodsHere, we performed ribosome footprint profiling (Ribo‐seq) and bulk messenger RNA (mRNA) sequencing in two NPM1‐mutated cell lines engineered to express endogenous NPM1c fused to the FKBP (F36V) degron tag (degron cells).Results and discussionIncubation of degron cells with the small compound dTAG‐13 enables highly specific degradation of NPM1c within 4 hours. As expected, RNA‐sequencing data showed early loss of homeobox gene expression following NPM1c degradation, confirming the reliability of our model. In contrast, Ribo‐seq data showed negligible changes in the ribosome footprint in both cell lines, implying that the presence of NPM1c does not influence ribosome abundance and positioning on mRNA. While it is predictable that NPM1c exerts its leukemogenic activity at multiple levels, ribosome footprint does not seem influenced by the presence of mutant NPM1.
Improved survival of pediatric deceased donor liver transplantation recipients after introduction of the pediatric prioritization system: Analysis of data from a Japanese national survey
Authors: Takemura Yusuke , Shinoda Masahiro , Kasahara Mureo , Sakamoto Seisuke , Hatano Etsuro , Okamoto Tatsuya , Ogura Yasuhiro , Sanada Yukihiro , Matsuura Toshiharu , Ueno Takehisa , Obara Hideaki , Soejima Yuji , Umeshita Koji , Eguchi Susumu , Kitagawa Yuko , Egawa Hiroto , Ohdan Hideki ,   the Japanese Liver Transplantation Society
Published: August 2024

AbstractBackgroundIn Japan, there has never been a national analysis of pediatric deceased donor liver transplantation (pDDLT) based on donor and recipient factors. We constructed a Japanese nationwide database and assessed outcomes of pDDLT focusing on the pediatric prioritization system introduced in 2018.MethodsWe collected data on pDDLTs (<18 years) performed between 1999 and 2021 from the Japan Organ Transplant Network and Japanese Liver Transplantation Society, identified risk factors for graft survival and compared the characteristics and graft survival in pDDLTs conducted before and after the introduction of the pediatric prioritization system.ResultsOverall, 112 cases of pDDLT were included, with a 1‐year graft survival rate of 86.6%. Four poor prognostic factors were identified: recipient intensive care unit stay, model for end‐stage liver disease/pediatric end‐stage liver disease score, donor cause of death, and donor total bilirubin. After the introduction of the system, allografts from pediatric donors were more reliably allocated to pediatric recipients and the annual number of pDDLTs increased. The 1‐year graft survival rate improved significantly as did pDDLT conditions indicated by the risk factors.ConclusionsUnder the revised allocation system, opportunities for pDDLT increased, resulting in favorable recipient and donor conditions and improved survival.
Ensemble‐based monthly to seasonal precipitation forecasting for Iran using a regional weather model
Authors: Najafi Mohammad Saeed , Kuchak Vahid Shokri 
Published: August 2024

AbstractMonthly and seasonal precipitation forecasts can potentially assist disaster risk reduction and water resource management. The aim of this study is to assess the skill of an ensemble framework for monthly and seasonal precipitation forecasts over Iran by focusing on system design and model performance evaluation. The ensemble framework presented in this paper is based on a one‐way double‐nested model that uses Weather Research and Forecasting (WRF) modelling system to downscale the second version of the NCEP Climate Forecast System (CFSv2). The performance is evaluated for October–April period at 1‐, 2‐ and 3‐month lead time. Multiple initial conditions, model parameters and physics are used to construct ensemble members. Using quantile mapping (QM) method, the outputs of the model are bias corrected. This methodology is applied for two periods: (i) climatology from 2000 to 2019 to evaluate the model's ability to precipitation forecast on a monthly and seasonal time scale; (ii) the forecast for 2020 to evaluate the model's performance operationally. The model evaluation is performed using the continuous (e.g., RMSE, r, MBE, NSE) and categorical (e.g., POD, FAR, PC, Heidke skill score) assessment metrics. We conclude that model outputs were improved by the QM bias correction method. According to results, the proposed ensemble framework can accurately predict amount of monthly and seasonal precipitation in Iran with an accuracy of 58 to 45% for lead‐1 to 3. For all three lead times, the averaged NSE, CC, MBE, and RMSE were 0.4, 0.56, −15.5, and 41.6, indicating that the framework has reasonable performance. Our results suggest that precipitation forecast accuracy varies with lead time, so the accuracy for lead‐1 is higher than lead‐2 and lead‐3. Additionally, the model's accuracy differs in various regions of the country and decreases in the spring. Using the approach for an operational case, it was found that the spatial features of precipitation predicted by the framework were close to those observed.
Quercetin promotes the proliferation, migration, and invasion of trophoblast cells by regulating the miR‐149‐3p/AKT1 axis
Authors: Wang Dan , Zhao Xin‐Rui , Li Yi‐Fan , Wang Rui‐Lin , Li Xue‐Bing , Wang Chun‐Xia , Li Yong‐Wei 
Published: August 2024

AbstractRecurrent spontaneous abortion (RSA) has a complex pathogenesis with an increasing prevalence and is one of the most intractable clinical challenges in the field of reproductive medicine. Quercetin (QCT) is an effective active ingredient extracted from Semen Cuscutae and Herba Taxilli used in traditional Chinese medicine for tonifyng the kidneys and promoting fetal restoration. Although QCT helps improve adverse pregnancy outcomes, the specific mechanism remains unclear. The trophoblast cell line HTR‐8/SVneo cultured in vitro was treated with different concentrations of QCT, and the cell counting kit‐8 assay, wound healing assay, transwell assay, and western blotting were used to evaluate the effects and mechanisms of QCT on the proliferation, migration, and invasion of HTR‐8/SVneo cells, respectively. To assess the expression levels of miR‐149‐3p and AKT serine/threonine kinase 1 (AKT1), quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blotting analysis were performed. A dual‐luciferase reporter assay was used to investigate the potential regulatory relationship between miR‐149‐3p and AKT1. Our results showed that QCT promoted the proliferation, migration, and invasion of trophoblast cells, promoted the expression of MMP2, MMP9, and vimentin, and downregulated the expression of E‐cadherin. Mechanistically, QCT downregulated the expression of miR‐149‐3p and upregulated the expression of AKT1, and miR‐149‐3p directly targets AKT1, negatively regulating its expression. Overexpression of miR‐149‐3p and silencing of AKT1 counteracted the promotional effects of QCT on trophoblast proliferation, migration, and invasion. Taken together, QCT regulates the migration and invasion abilities of HTR‐8/SVneo cells through the miR‐149‐3p/AKT1 axis, which may provide a promising therapeutic approach for RSA.
Anterior cruciate ligament repair using dynamic intraligamentary stabilization grants 88.5% survival at minimum follow‐up of 5 years
Authors: Henle Philipp , van Rooij Floris , Agu Chinyelum , Eggli Stefan 
Published: August 2024

AbstractPurposeThe aim of this study was to report on the revision rates and clinical outcomes following dynamic intraligamentary stabilization (DIS) at a minimum follow‐up of 5 years and to investigate which preoperative or intraoperative characteristics could influence revision rates or clinical scores.MethodsThe authors retrospectively assessed all 609 knees that underwent ACL repair using DIS at a single centre. At a minimum follow‐up of 5 years, patients were assessed using the Lysholm, International Knee Documentation Committee (IKDC) and Tegner scores, as well as passive flexion and extension.ResultsAt a follow‐up of 5.1 ± 0.3 years (range, 5–10), of the 609 patients, 428 patients were available for clinical assessment. Anterior tibial translation decreased from 9.7 ± 2.1 to 7.8 ± 1.9 mm, and side‐to‐side difference decreased from 4.3 ± 2.3 to 1.5 ± 1.8 mm. The postoperative Lysholm score was 96.9 ± 5.6, subjective IKDC was 95.6 ± 6.1 and Tegner scores ranged from 4 to 11, of which 51% of patients had a score of 7 or more. The estimated survival rate was 86% for the first half of the cohort and increased to 91% for the second half of the cohort.ConclusionAt a minimum follow‐up of 5 years following ACL repair using DIS, it was found that it grants satisfactory clinical outcomes and that surgeons should inform patients who have predispositions about the higher risk of revision.Level of EvidenceLevel IV retrospective study.
Increased anterior tibial subluxation and differences between anterior tibial subluxation in the lateral and medial compartments are associated with failure of primary anterior cruciate ligament reconstruction: A systematic review and meta‐analysis
Authors: Bai Wenbin , Zhang Zhiyu , Hong Lejin , Dai Wenli , Meng Qingyang , Shi Weili , Wang Cheng 
Published: August 2024

AbstractPurposeThe purpose of this study is to investigate whether increased anterior tibial subluxation (ATS) and differences between ATS in the lateral and medial compartments (ATSL−M) are associated with primary anterior cruciate ligament (ACL) reconstruction (ACLR) failure.MethodsPubMed, Scopus, Embase and Web of Science were systematically searched from their inception through 21 November 2023. The focus was on comparative studies reporting ATS in patients who experienced primary ACLR failure, in contrast to patients after primary ACLR with no evidence of graft failure. A random‐effects model was employed to calculate the overall standardized mean difference between the two groups.ResultsA total of eight studies involving 963 patients were included in the final review. Three studies (64 cases and 171 controls) measured ATS on radiographs. The failed ACLR group exhibited a significantly increased ATS on radiographs compared to the control group (p < 0.001). Six studies (324 cases and 488 controls) measured lateral ATS on magnetic resonance imaging and five of them (285 cases and 374 controls) also measured medial ATS. The average values of lateral and medial ATS, as well as ATSL−M, were calculated and compared between the two groups. The failed ACLR group demonstrated significantly increased lateral (p < 0.001) and medial ATS (p < 0.001), the average value of lateral and medial ATS (p < 0.001) and ATSL−M (p = 0.039) compared to the control group.ConclusionIncreased ATS and ATSL−M are associated with primary ACLR failure. The measurement of tibiofemoral position shows promise for its application in preoperative planning and postoperative management of ACLR.Level of EvidenceLevel III.
Improved Survival of Advanced‐Stage Anaplastic Thyroid Cancer With Systemic Therapy
Authors: Evans Lauran K. , Chen Haidee , Taki Labib Manwel , Cronkite D. Alexander , Yu Alice C. , Ashendouek Maya , Elashoff David , Chai‐Ho Wanxing , Wong Deborah J. , St. John Maie 
Published: August 2024

ObjectivesAnaplastic thyroid cancer (ATC) is the most aggressive and fatal thyroid malignancy. Currently, there still exists a paucity of literature studying the relationship between available ATC‐targeted therapy, immunotherapy, and survival. We aim to investigate how systemic therapies affect survival outcomes in ATC.MethodsA single‐tertiary‐institution chart review of patients diagnosed with advanced‐stage ATC, and who underwent surgery as part of their treatment, was performed between 2000 and 2023, with 41 patients included. Demographics, clinical characteristics, and survival data were collected and analyzed via Kaplan–Meier and Cox proportional hazards analyses.Results54% of patients were female, and average age was 67.4 years old. The most common mutations identified were BRAF (15 patients), p53 (9 patients), and p63 (2 patients). A total of 18 patients utilized targeted or immunotherapy, with Trametinib and Dabrafenib (9 patients) as the most common agents used. Two‐year overall survival was 24%, and 5‐year overall survival was 23%, with median survival time of 7.6 months. Kaplan–Meier analysis demonstrated improved survival in patients who received chemotherapy (p = 0.048). Cox proportional hazards analysis demonstrated that patients treated with immunotherapy or targeted therapy had a statistically significant increase in survival compared with patients who did not receive these therapies (p = 0.016). Additionally, females and those with a p63 mutation demonstrated improved survival outcomes (p = 0.010, p = 0.001).ConclusionsTargeted therapy and immunotherapy use should be strongly considered when treating patients with ATC. Further studies into novel drugs targeting immune checkpoints and combination therapy are needed to better optimize treatment of patients with ATC.Level of Evidence3 Laryngoscope, 2024
Non‐Hermitian Skin Effect in Non‐Hermitian Optical Systems
Authors: Zhang Yingqiu , Wei Zhongchao 
Published: August 2024

AbstractThe development of non‐Hermitian (NH) physics in nonconservative systems has led to various interesting wave phenomena, including the emergence of the non‐Hermitian skin effect (NHSE). NHSE is a topological effect caused by the nontrivial winding number of the energy spectrum, which results in many bulk eigenmodes localized on low‐dimensional boundaries under open boundary conditions. Although this phenomenon is striking, the flexible and dynamic tuning of NHSE has not been reviewed in optics systems. As an ideal NH platform, an optical system can introduce artificially constructed gains and losses and flexibly design optical structures to control the transmission and regulation of light. This exploration based on NH optical systems deepens the understanding of NHSE and facilitates technological breakthroughs in high‐energy directional localized optics applications. In this review, the focus is on the latest progress and applications of NHSE in NH optical systems, including the basic theory and local property modulation methods. Finally, possible future research directions for NHSE based on NH optical systems are discussed.