bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of manual vaginal morcellation with laparoscopic power morcellation in specimen retrieval during laparoscopic myomectomy
Authors: Nambiar Muralikrishnan , Suresh Y Anupama , Surendran Jithin , Sreenivas Athulya , Bhat Shreevidya 
Published: February 2025

Most popular specimen retrieval techniques in laparoscopic myomectomy are manual vaginal morcellation and power morcellation. This prospective study was conducted from October 2018 to September 2022 and included 150 patients who underwent laparoscopic myomectomy.: Specimen extraction time was about 9.744 ±1.076 minutes in the vaginal morcellation group and 77.366 ±324.067 minutes in power morcellation group (p value 0.062). Cost of surgery in US dollars was 954.550± 2.272 USD in vaginal morcellation group and 1266.329± 215.246 USD in power morcellation group (p value &#60; 0.001). About 0.013± 0.112 patients in vaginal morcellation group required of additional analgesia post operatively. This was required in about 0.171 ± 0.379 patients in power morcellation group (p value &#60; 0.001). Patients who had vaginal morcellation were discharge ready at 128.625 ± 13.664 minutes. Where as this was 182.561± 30.381 minutes in power morcellation group (p value of &#60; 0.001). About 0.013± 0.112 patients in the vaginal morcelaltion group had wound related adverse effects. About 0.171 ± 0.379 patients had such adverse effects in the power morcellation group (p value &#60; 0.001). : From our findings we conclude that Manual vaginal morcellartion is a much quicker, inexpensive and less painful alternative to power moecellation to extract specimens after laparoscoic myometomy. Manual vaginal morcellation also has less wound related complications with quicker post operative discharge readiness.
Saúde Coletiva e branquitude: uma revisão de literatura integrativa
Authors: Loureiro Ferreira de Carvalho Polyana , Francisco Lima da Silva Diego , Castelo Branco Correia Lins Aryadne 
Published: February 2025

Introduction: This article presents as a research question: “What has been discussed within the literature in the field of Collective Health about the social construction of Whiteness and its impacts from racism?”. Objective: To discuss, based on a literature review, the concept of Whiteness in Public Health studies. Methodology: This is an integrative literature review, focusing to the academic production of Collective Health linked to studies on Whiteness. For the research, the descriptors were chosen by consulting the Descriptors in Health Sciences - DeCS of the Virtual Health Library - VHL platform of BIREME. The search was conducted place in September 2022, through the Scientific Electronic Library Online - Scielo digital library. The analysis of the study was based on Content Analysis, which foresees the classification of the analyzed results in different or similar categories, through a set of techniques applied in the field of communications. Results: The search found 53 journals. Based on the inclusion and exclusion criteria, an analysis of the titles, abstracts and reading was carried out, where 08 articles were identified that discussing the pre-established themes. Discussion: The construction of a racial consciousness is crucial to recognize the structures of power and the social construction of our country, which is crossed by racism in its formation. Whiteness is perpetuated through institutions, cultural norms and social practices, it is not a static concept, but it highlights the privileges to which a segment of the population has access.
Effect of Mustard-based Intercropping Systems on Efficiency Indices under Organic Management
Authors: Singh Umesh Kumar , Gangwar B. , Kumar Sourabh , Kumar Rajiv 
Published: February 2025

Background: Intercropping has potential to increase land productivity by leveraging species complementarities and a means to achieve sustainable agricultural intensification. The mustard intercropping with other crops significantly modified the competition parameters when compared to their comparable sole crops. Methods: An experiment was carried out at Organic Research Farm, Karguaji, Institute of Agricultural Sciences, Bundelkhand University, Jhansi, during Rabi 2021-22 to investigate the effect of mustard-based intercropping systems utilizing the skip-row method on efficiency indices under organic management. Nine treatments were investigated, including mustard, kabuli chickpea, field pea, fenugreek and desi chickpea as sole crops, mustard + kabuli chickpea, mustard + field pea, mustard + fenugreek and mustard + desi chickpea (1:2 ratio) in an intercropping system omitting one row of mustard. Result: Intercropping of mustard with desi chickpea showed positive trends in terms of efficiency indices with higher CGR (17.8 g.day-1cm-2), RGR (17.90 g.g-1.day-1), LER (1.64), MEY (26.7qha-1), CEY (25.87 qha-1) and ATER (1.64) which ultimately resulted in highest profitability (Rs 888 ha-1 day1).
Pain Type and Quality of Life in Cervicogenic Headache Patients
Authors: Sudibyo Devi Ariani , Fathoni M Reza , Puti Nazla Ananda Rachmi 
Published: February 2025

Highlight:

Cervicogenic headache is the most incapacitating type, leading to significant physical impairment.
Based on the data, there were 15 subjects in the nociceptive pain group and 15 subjects in the neuropathic pain group.
There was a statistically significant correlation between the type of pain and the mental quality of life. In patients with cervicogenic headaches and neuropathic pain, there was a stronger relationship than those with nociceptive pain.

ABSTRACT
Introduction: Cervicogenic headache is classified as a secondary headache under the International Classification of Headache Disorders, third edition (ICHD-3). Significant neuropathic and nociceptive pain components are believed to be present in this condition, which eventually lowers quality of life by causing problems like anxiety, depression, and sleep disruptions. Objective: This study aimed to correlate pain types with quality of life in those suffering from cervicogenic headaches. Methods: A cross-sectional observational study was conducted at the Neurology Outpatient Clinic of Dr. Soetomo General Academic Hospital in Surabaya from June to August 2020. Quality of life and pain types were evaluated using the painDETECT and SF-36 questionnaires. A painDETECT score of 12 or less indicated nociceptive pain, but a score of more than 12 indicated neuropathic pain. An SF-36 score below 50 indicated a poor quality of life. Conclusion:Patients with cervicogenic headaches and neuropathic pain exhibited a lower quality of life compared to those experiencing nociceptive pain. These findings emphasize the importance of evaluating pain types to support the maintenance of a good quality of life.
Neuroimaging and Intravenous Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke beyond 4.5 Hours: A Systematic Review
Authors: Ghifari Muhammad Ramadhan , Deskianditya Resa Budi , Oviyanti Pradana Nur , Maatisya Yuki Fitria , Putri Vega Pratiwi 
Published: February 2025

Highlight:

Ischemic stroke is a major cause of disability and death globally, emphasizing the urgent need for timely and effective thrombolytic interventions within a narrow treatment window.
Neuroimaging has the potential to extend the therapeutic window for IV rt-PA beyond 4.5 hours, allowing clinicians to identify patients with salvageable brain tissue for treatment.
Extending the IV rt-PA treatment window with neuroimaging support can significantly improve outcomes in stroke patients, although careful risk assessment is crucial.

ABSTRACT
Introduction: Current guidelines suggest giving intravenous recombinant tissue plasminogen activator (rt-PA) within 4.5 hours after acute ischemic stroke onset or the time the patient was last-seen-well. Patients often arrive at the hospital after 4.5 hours, making thrombolysis treatment challenging. It is crucial to examine expanding this timeframe beyond 4.5 hours of onset or last-seen-well. Objective: This systematic review intended to examine the effectiveness and safety of IV rt-PA in patients presenting to the hospital beyond 4.5 hours of onset or last-seen-well. Methods: We searched PubMed, Scopus, and ScienceDirect for studies on acute ischemic stroke patients treated with IV rt-PA alteplase beyond 4.5 hours of onset or last-seen-well. Outcomes comprised the Modified Rankin Scale (mRS) score, intracranial hemorrhage (ICH), symptomatic ICH, and mortality. We assessed the risk of bias using Cochrane Risk of Bias Vol 2 and ROBINS-I. Results: Eleven randomized controlled trials and observational studies were selected. Most subjects were above 65 years, and their baseline mean or median NIHSS scores were 6–12. Seven studies had specific neuroimaging criteria for eligibility, such as DWI/FLAIR or T2WI mismatch, PWI/DWI mismatch, or CT/MR perfusion. In RCTs, alteplase group had 47.1% to 53.3% favourable results (mRS 0-1) compared to 41.3% to 48.3% in placebo/controls group and 23% to 85% in observational studies. Compared to the placebp/control group and onset within 4.5 hours, alteplase typically had better ourcomes. However, ICH, symptomatic ICH, and mortality were numerically higher, albeit not statistically significant. Conclusion: IV rt-PA alteplase can be given for up to 9-12 hours from onset or last-seen-well with neuroimaging evidence of salvageable tissue, such as the perfusion imaging RAPID criteria or DWI/FLAIR or T2WI mismatch, taking consideration of hemorrhage and mortality concerns.
Epidemiological Study of Stroke Disease in the Southeast Maluku Islands Region in 2023
Authors: Paliyama Febryn Prisiliya , Rinaldi Fransiskus Xaverius , Silalahi Parningotan Yosi , Nari Janti Pare 
Published: February 2025

Highlight:

The prevalence of stroke in Southeast Maluku is 14.1 per 1,000 population for 2023.
Ischemic stroke is the most common type of stroke in the Southeast Maluku Islands.
The most prevalent chronic disease among stroke patients in Southeast Maluku Islands is hypertension.

ABSTRACT
Introduction: Stroke is a serious health problem with a high mortality rate and incidence, especially in low- and middle-income regions like Southeast Maluku, Indonesia. Inadequate facilities and risk factors causing high stroke rates in this region provide major healthcare challenges. Epidemiological data highlight the pressing need for healthcare development. Objective: This epidemiological study aimed to provide insight on the prevalence of stroke in the Southeast Maluku Islands in 2023, with the goal of enhancing the urgency of measures to reduce stroke incidences there. Methods: This study used a descriptive methodology with a cross-sectional design. Data were collected by obtaining thorough medical records from stroke patients at Karel Sadsuitubun Regional General Hospital. Demographic information, stroke type, and comorbidities were analyzed, as well as the prevalence rate calculated from the entire patient population of 8,436 as reported in 2023, while also classifying patients by age and gender. Results: In the Southeast Maluku Islands, 107 stroke cases were reported, equal to a stroke prevalence rate of 12.6 per 1,000 people. The most common type was ischemic stroke (95.33%), followed by hemorrhagic stroke (4.67%). Hypertension, which affected 67.2% of patients, was the most common comorbidity, followed by type II diabetes mellitus and coronary artery disease. Conclusion:Stroke rates have increased in the Southeast Maluku Islands due to a variety of factors, including socioeconomic conditions and unhealthy lifestyles. The study’s findings emphasize the urgent need for interventions to reduce stroke rates.
Epidemiologic Profile of Ischemic Stroke Patients with Dyslipidemia in Dr. Soetomo General Academic Hospital Patient
Authors: Prakoso Raditya Ardra Putra , Ardhi Mohammad Saiful , Thamrin Husin , Setyowatie Sita 
Published: February 2025

Highlight:

This study provides insights into the epidemiologic profile of ischemic stroke patients with dyslipidemia in Dr. Soetomo General Academic Hospital.
The majority of patients had hypertension, the most common comorbidity with low HDL-C levels
Most patients showed moderate stroke severity and high levels of consciousness, with a majority proportion demonstrating recovery.

ABSTRACT
Introduction: Ischemic stroke is a major medical issue, especially in individuals with dyslipidemia, as it can elevate both the likelihood and severity of stroke incidents. This study is essential due to the rising prevalence of stroke and limited data regarding ischemic stroke patients with dyslipidemia in Indonesia. Understanding these traits is important for enhancing preventative and treatment strategies. Objective: This study intended to assess the epidemiologic profile of ischemic stroke patients with dyslipidemia in a tertiary hospital in Indonesia. Methods: This descriptive study assessed 116 medical records of ischemic stroke patients with dyslipidemia admitted to Dr. Soetomo General Academic Hospital in Surabaya, Indonesia, from January to June 2023. The collected data encompassed demographics, comorbidities, lipid profiles, and clinical outcomes. Dyslipidemia was defined based on the PERKENI guidelines, and stroke severity was assessed using the GCS and NIHSS scales. Results: The majority of ischemic stroke patients with dyslipidemia (77.6%) had low HDL-C levels. There were 64 males and 52 females; most of them were between the ages of 56 and 65. Hypertension was the most common comorbidity (64.7%), followed by diabetes (39.7%), heart disease (12.9%), and obesity (11.2%). Of 40 NIHSS-assessed patients, 26 had moderate, 8 mild, 2 moderate-to-severe, and 4 severe strokes. The majority of patients (70.7%) recovered. Conclusion:The majority of dyslipidemia-related ischemic stroke patients, aged 56 to 65, had low HDL-C levels. Hypertension was the main comorbidity, with many experiencing their first stroke. Most patients had high consciousness, moderate stroke severity, and showed improvements.
Efficacy of Hyperbaric Oxygen Therapy in Systemic Lupus Erythematosus Patients Undergoing Maxillofacial Surgery
Authors: Eko Mukti Wibowo  , Ganendra Anugraha  , Agung Satria Wardhana  
Published: February 2025

Highlights

SLE is the most common autoimmune disease that requires management after maxillofacial surgery.
Hyperbaric oxygen therapy is a treatment that can help accelerate recovery in patients.

Abstract
Background: Systemic Lupus Erythematosus (SLE) is a common multifactorial autoimmune disease that carries a high risk of osteoporosis and fractures. The delivery of oxygen to the body's tissues through hyperbaric oxygen treatment (HBOT) promotes the healing of wounds and shortens the typical recovery time for patients. The way tissues react to illnesses and injuries can be altered by HBOT. Objective: This article aimed to determine the use of hyperbaric oxygen therapy (HBOT) post-maxillofacial surgery in SLE patients. Materials and Method: This research used a scoping review approach, accessing electronic databases like PubMed, Scopus, Science Direct, Elsevier, and Google Scholar. Discussion: SLE is characterized by producing various autoantibodies that interact with endogenous antigens, favoring widespread inflammatory injury. SLE impacts the immune system, diminishing its ability to defend against infections. Hyperbaric oxygen therapy refers to administering 100% oxygen to a patient inside a pressurized chamber with a pressure higher than one atmosphere at sea level. The surgical placement of the implant into the mandible or maxilla allows it to be retained during functional loading, as the bone integrates with the implant during growth. Conclusion: HBOT can improve the host response by activating inflammatory cells and ensuring optimal oxygen tension in people with SLE. This can help with osteogenesis and neovascularization, which fill empty spaces with new blood vessels or bone tissue.
Gut-Brain Axis, Notch, and Brain Cancer: ‘The Rising Three’
Authors: Gembong Satria Mahardhika  , Norina Agatri  
Published: February 2025

Highlights

The gut-brain axis (GBA) is a bidirectional communication network linking the gastrointestinal tract and the central nervous system (CNS), involving neurons and various signaling molecules such as endocrine, humoral, metabolic, and immunological factors.
The Notch signaling pathway is implicated in the development of brain tumors, including gliomas, which show elevated Notch receptor levels. This pathway is critical in tumor cell proliferation, survival, and invasiveness.

Abstract
Background: The gut-brain axis (GBA) facilitates reciprocal communication between the central and enteric nervous systems. The connection between the GBA, Notch, and brain cancer is a complex and intricate subject that warrants further exploration. Brain cancer has a multifaceted pathophysiology and structure, making the journey from diagnosis to treatment challenging. The involvement of Notch in the signaling pathway could be relevant to both brain cancer and the gut-brain axis. Objective: This research aimed to examine the complex interplay between the gut-brain axis (GBA), Notch signaling, and brain cancer, specifically gliomas. Material and Method: This study was a scoping review conducted using multiple search engines, including PubMed, ProQuest, and Cambridge Core, spanning from 2018 to 2023. The collected materials were filtered and subsequently analyzed. Result: The existence of the gut-brain axis is a fascinating topic for in-depth exploration. The complex relationship between Notch and the gut-brain axis may offer valuable insights into the pathogenesis of brain cancer. The literature review identified two publications, which were analyzed in more detail. The gut-brain axis (GBA) refers to a bidirectional communication network between the central nervous system and the enteric nervous system, regulating gastrointestinal functions. The identification of the Notch signaling pathway suggests its role in the development of brain tumors. Conclusion: The connections between the gut-brain axis, Notch, and brain cancer are evident. The Notch pathway, as a signaling mechanism, is linked to brain cancer, and the gut-brain axis is also associated with it. This interconnected relationship has the potential to uncover novel avenues for diagnosis and therapy, warranting further research.
Strategi Pemasaran Kerupuk Udang di Desa Tanjung Dewa Kecamatan Panyipatan Kabupaten Tanah Laut (Studi Kasus pada Usaha Kerupuk Udang Merek Nyai Kasnah)
Authors: Septiana Dwi , Fauzi Muhammad , Azis Yusuf 
Published: February 2025

Kerupuk udang merek Nyai Kasnah merupakan usaha perorangan yang dimiliki oleh ibu Kasnah yang beroperasi sejak 2011 hingga sekarang. Keberadaan strategi pemasaran didasarkan pada analisis menyeluruh terhadap dampak faktor lingkungan eksternal dan internal perusahaan. Lingkungan eksternal perusahaan berubah dengan cepat setiap saat, menciptakan berbagai peluang dan risiko baik dari pesaing utamanya maupun lingkungan bisnis yang selalu berubah. Penelitian ini dilaksanakan pada pada bulan Juli 2023 hingga oktober 2023 usaha pengolahan kerupuk udang “Nyai Kasnah” produksi Nyai Kasnah yang terletak di desa Tanjung Dewa Kecamatan Panyipatan, Kabupaten Tanah Laut. Metode yang digunakan dalam penelitian ini adalah metode studi kasus. Berdasarkan Identifikasi faktor internal yang mendapatkan hasil enam faktor kekuatan dan lima faktor kelemahan yang dimiliki usaha Kerupuk Udang Nyai Kasnah. Sedangkan faktor eksternal mendapatkan hasil lima faktor peluang dan empat faktor ancaman. Strategi yang dimiliki kerupuk udang Nyai Kasnah berada di kuadran I yang berarti menguntungkan. Nyai Kasnah dapat memanfaatkan kekuatan yang dimiliki sebagai peluang usaha.
Analisis Pengendalian Persediaan Bahan Baku Kerupuk Bawang “Mr” di Kecamatan Cempaka Kota Banjarbaru
Authors: Raihanah Raihanah , Yulianti Mira , Budiwati Nina 
Published: February 2025

Penelitian ini bertujuan untuk menganalisis pengendalian persediaan yang diterapkan pada usaha kerupuk bawang “MR” dan untuk menganalisis jumlah pesanan persediaan yang ekonomis pada usaha kerupuk bawang “MR” di Kecamatan Cempaka Kota Banjarbaru. Penelitian ini dilaksanakan pada tahun 2023. Penelitian ini menggunakan metode studi kasus. Jenis data yang digunakan yaitu data primer dan sekunder. Berdasarkan hasil penelitin, frekuensi pemesanan usaha kerupuk bawang “MR” yaitu 10 kali pada periode tahun 2022, dengan 1 kali pemesanan setiap bulan, biaya pemesanan Rp3.673.000,00 untuk 713 kg kerupuk bawang dan Rp1.514.840,00 untuk biaya penyimpanan, jadi totalnya mencapai Rp5.187.000,00. Usaha kerupuk bawang “MR” tidak memiliki Sefety Stock (Persediaan Pengaman jadi usaha ini pernah mengalami kekurangan bahkan kehabisan bahan baku. Dengan menggunakan metode EOQ (Economic Order Quantity), didapat jumlah pesanan ekonomis dengan frekuensi pemesanan 2 kali dalam setahun dengan jumlah pemebelian 496 kg kerupuk bawang, usaha kerupuk bawang “MR” dapat membayar biaya pemesanan ekonomis sebesar Rp527.944,00 per pesan dan biaya penyimpanan sebesar Rp527.000,00 Safety Stock (Persediaan Pengaman) sebanyak 48 kg untuk menghindari kekurangan persediaan kerupuk bawang. Jika kerupuk bawang mencapai sebanyak 16,2 kg, ROP dilakukan. Waktu tunggu adalah sekitar 6 hari.
Caractérisation de la dynamique d’accumulation du sucre dans le raisin et des facteurs influençant ce processus à l’échelle locale
Authors: De Rességuier Laure , Inchboard Lauren , Parker Amber K. , Petitjean Théo , Van Leeuwen Cornelis 
Published: February 2025

Déterminer la concentration en sucre dans les baies de raisin est essentiel pour les viticulteurs, car elle permet d'évaluer le degré d’alcool du vin final et d'optimiser la date de récolte. Face au changement climatique et à l'augmentation des températures, comprendre les facteurs qui affectent la dynamique d'accumulation du sucre est crucial pour adapter les pratiques viticoles et maintenir la qualité des vins. Cette étude vise à analyser les facteurs de développement et environnementaux impliqués dans l'accumulation du sucre dans les raisins, en utilisant des données collectées dans la région de Saint-Émilion, Pomerol et leurs appellations satellites (Bordeaux, France) (de Rességuier et al., 2024).
Study on Molecular Mechanism of Cysticercus Cellulosae TPx Protein Regulating Th1/Th2 Cell Imbalance Through JAK/STAT Signaling Pathway
Authors: Mu Qianqian , Cai Haojun , Xiong Haiting , Zhou Biying 
Published: February 2025

Cysticercosis is a serious zoonotic parasitic disease caused by the larval cysts of Taenia solium parasitizing humans or pigs. The immune pathogenesis of this disease is currently unclear. Preliminary studies found that the thioredoxin peroxidase (TPx) protein in the excretory-secretory antigens (ESA) of the cysticercus cellulosae can induce T-cell immune imbalance in piglets, leading to a Th2-type immune response. In this study, flow cytometry revealed that TPx protein can induce Th1 cells differentiation within 24 hours and Th2 cells differentiation within 48 hours. Further analysis of the different transcriptomes after TPx protein treatment of Jurkat T cells suggested that TPx protein may induce host Th1/Th2 cells imbalance through the janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway. Western blot results indicated that treatment with TPx protein for 48 hours significantly increased the expression of p-JAK3, p-STAT6, and GATA3 proteins. Interestingly, after using a JAK3 inhibitor, the expression level of the Th1 transcription factor TBX21 significantly increased, indicating that after inhibiting Th2 cells differentiation, T cells tend to differentiate toward the Th1 cells direction. In summary, the JAK/STAT signaling pathway plays a key role in the cysticercus cellulosae TPx protein induced Th1/Th2 cells imbalance, providing important scientific evidence for elucidating the immune pathogenesis of cysticercosis and vaccine development.