bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational risks and health of nursing workers – seeking evidences
Authors: Loro Marli Maria , Zeitoune Regina Celia , Guido Laura de Azevedo , Da Silva Rosângela Marion , Kolankiewicz Adriane Cristina Bernat 
Published: November 2014

Objetivo:Identificar a produção científica nacional e internacional acerca dos riscos ocupacionais da equipe de enfermagem que atua no âmbito hospitalar. Método: O tipo do estudo foi de Revisão integrativa da literatura. O levantamento bibliográfico foi realizado pela Biblioteca Virtual em Saúde, nas bases de dados BIREME, Lilacs, Scielo,Biblioteca Cochrane e Medline. Foram utilizados os descritores equipe de enfermagem or "enfermagem" and riscos ocupacionais or "riscos ocupacionais and “acidente de trabalho”. Resultados: Identificou-se 204 artigos e a amostra final foi composta por 30 artigos científicos produzidos pela enfermagem ou com sua participação, publicados em território nacional e internacional. Conclusão: A partir da busca do produzido evidenciou-se a necessidade de implementar momentos de educação permanente, focando práticas reflexivas, pois o campo da Saúde do Trabalhador, por vezes, centraliza-se em treinamentos pontuais, em que o trabalhador recebe instruções de como proceder/portar-se. Descritores: Enfermagem, Saúde do trabalhador, Risco ocupacional.
Communication with people with hearing disabilities: an integrative review
Authors: De Miranda Rodrigo Sousa , Shubert Carla Oliveira , Alves Machado Wiliam César 
Published: November 2014

Objetivo: Identificar na literatura como ocorre a comunicação entre profissionais de saúde e os pacientes com deficiência auditiva. Método: Revisão integrativa. A busca foi realizada nas bases de dados MEDLINE, BDENF, LILACS e SciELO por meio de seus descritores: comunicação, enfermagem, deficiência auditiva, surdez, surdos e cuidados de enfermagem. Resultados: Os 19 artigos foram agrupados nas seguintes categorias: estratégias de comunicação; formação profissional; relacionamento do profissional com o surdo e sugestões para melhoria da comunicação entre surdos e profissionais de saúde. Conclusão: Cada surdo apresenta necessidades comunicacionais específicas, cabendo ao enfermeiro a escolha, junto com o surdo, da melhor estratégia de comunicação, respeitando suas limitações.
α‐L‐Rhamnosyl‐β‐D‐glucosidase (Rutinosidase) from Aspergillus niger: Characterization and Synthetic Potential of a Novel Diglycosidase
Authors: Šimčíková Daniela , Kotik Michael , Weignerová Lenka , Halada Petr , Pelantová Helena , Adamcová Kateřina , Křen Vladimír 
Published: November 2014

AbstractWe report the first heterologous production of a fungal rutinosidase (6‐O‐α‐L‐rhamnopyranosyl‐β‐D‐glucopyranosidase) in Pichia pastoris. The recombinant rutinosidase was purified from the culture medium to apparent homogeneity and biochemically characterized. The enzyme reacts with rutin and cleaves the glycosidic linkage between the disaccharide rutinose and the aglycone. Furthermore, it exhibits high transglycosylation activity, transferring rutinose from rutin as a glycosyl donor onto various alcohols and phenols. The utility of the recombinant rutinosidase was demonstrated by its use for the synthesis of a broad spectrum of rutinosides of primary (saturated and unsaturated), secondary, acyclic and phenolic alcohols as well as for the preparation of free rutinose. Moreover, the α‐L‐rhamnosidase‐catalyzed synthesis of a chromogenic substrate for a rutinosidase assay – para‐nitrophenyl β‐rutinoside – is described.magnified image
Variability of fractional flow reserve according to the methods of hyperemia induction
Authors: Lim Woo‐Hyun , Koo Bon‐Kwon , Nam Chang‐Wook , Doh Joon‐Hyung , Park Jin Joo , Yang Han‐Mo , Park Kyung Woo , Kim Hyo‐Soo , Takashima Hiroaki , Waseda Katsuhisa , Amano Tetsuya , Kato Daiki , Kurita Akiyoshi , Oi Maki , Toyofuku Mamoru , van Nunen Lokien , Pijls Nico H.J. 
Published: November 2014

ObjectivesWe performed this study to evaluate the variability of fractional flow reserve (FFR) values which were measured from various methods of hyperemia induction.BackgroundConcerns have been raised regarding the variability of FFR due to different routes for hyperemic agent administration and different hyperemic agents targeting different receptors to induce maximal hyperemia.MethodsA total of 656 intermediate coronary lesions from 628 patients with coronary artery disease were analyzed. Among them, 238 lesions underwent FFR measurement with hyperemia induced by both intravenous (IV) and intracoronary (IC) adenosine administration, 318 by IV adenosine/adenosine triphosphate (ATP) and IC nicorandil injection, and 100 by IV adenosine and regadenoson infusion.ResultsExcellent correlation and close classification agreement (FFR ≤ 0.80) were observed between IV vs. IC adenosine (r = 0.980, CA = 92.9%, Cohen's Kappa = 0.887, P < 0.001), between IV adenosine/ATP vs. IC nicorandil (r = 0.962, CA = 91.2%, Cohen's Kappa = 0.817, P < 0.001), and between IV adenosine vs. regadenoson (r = 0.990, CA = 100%, Cohen's Kappa = 1.000, P < 0.001). When changes in blood pressure (ΔBP) or heart rate (ΔHR) were compared with changes in FFR (ΔFFR) between IV adenosine/ATP and IC nicorandil administration, there were no significant correlations between ΔBP and ΔFFR nor between ΔHR and ΔFFR (r = −0.122, P = 0.076; r = 0.036, P = 0.605, respectively).ConclusionsThis study suggests that the measurement of FFR is reproducible regardless of the hemodynamic changes, hyperemic agents used, or the route of administration. © 2014 Wiley Periodicals, Inc.
p‐Element‐Doped Graphene: Heteroatoms for Electrochemical Enhancement
Authors: Poh Hwee Ling , Pumera Martin 
Published: November 2014

AbstractGraphene is finding important applications in electrochemistry. Here, we discuss how the doping of graphene with heteroatoms, namely boron, nitrogen, phosphorus, sulfur, fluorine, chlorine, bromine, and iodine, change the electrochemical properties of the material. In addition, we summarize the different doping routes and show that the process has an influence upon electrochemical properties.
Molecular‐Level Insights into Intrinsic Peroxidase‐Like Activity of Nanocarbon Oxides
Authors: Zhao Ruisheng , Zhao Xiang , Gao Xingfa 
Published: November 2014

AbstractNanocarbon oxides have been proved to possess great peroxidase‐like activity, catalyzing the oxidation of many peroxidase substrates, such as 3,3′,5,5′‐tetramethylbenzidine (TMB) and o‐phenylenediamine dihydrochloride (OPD), accompanied by a significant color change. This chromogenic reaction is widely used to detect glucose and occult blood. The chromogenic reaction was intensively investigated with density functional theory and molecular‐level insights into the nature of peroxidase‐like activity were gained. A radical mechanism was unraveled and the carboxyl groups of nanocarbon oxides were identified as the reactive sites. Aromatic domains connected with the carboxyl groups were critical to the peroxidase‐like activity.
Solution Polymeric Optical Temperature Sensors with Long‐Term Memory Function Powered by Supramolecular Chemistry
Authors: de la Rosa Victor R. , Hoogenboom Richard 
Published: November 2014

AbstractA poly[(2‐ethyl‐2‐oxazoline)‐ran‐(2‐nonyl‐2‐oxazoline)] copolymer in combination with hydroxypropylated cyclodextrins has been demonstrated to lead to a supramolecular self‐assembly process that results in the formation of kinetically trapped thermoresponsive nanoparticles. Selection of the cyclodextrin type provides control over the nanoparticle phase‐transition thermodynamics, thus affording optical temperature sensors with an unprecedented, long‐term thermal memory function, which is reversible or irreversible. This research also sheds light onto kinetic and dynamic supramolecular assemblies, thus providing important insight because similar supramolecular processes are at the foundation of living matter.
Reactions of Osmabenzene with Silver/Copper Acetylides: From Metallabenzene to Benzene
Authors: Han Feifei , Li Jinhua , Zhang Hong , Wang Tongdao , Lin Zhenyang , Xia Haiping 
Published: November 2014

AbstractThe transformations of metallabenzene to substituted benzenes have been achieved by reactions of osmabenzenes with silver/copper acetylides. In this investigation, novel tetraphenylphosphonium salts containing two phosphonium substituents on the same benzene ring are generated.
Molybdenum Complexes Supported by Mixed NHC/Phosphine Ligands: Activation of N2 and Reaction With P(OMe)3 to the First Meta‐Phosphite Complex
Authors: Gradert Christian , Stucke Nadja , Krahmer Jan , Näther Christian , Tuczek Felix 
Published: November 2014

AbstractMolybdenum(0) dinitrogen complexes, supported by the mixed NHC/phosphine pincer ligand PCP, exhibit an extreme activation of the N2 ligand due to a very π‐electron‐rich metal center. The low thermal stability of these compounds can be increased using phosphites instead of phosphines as coligands. Through an amalgam reduction of [MoCl3(PCP)] in the presence of trimethyl phosphite and N2 the highly activated and room‐temperature stable dinitrogen complex [Mo(N2)(PCP)(P(OMe)3)2] is obtained. As a second product, the first transition metal complex containing the meta‐phosphite ligand P(O)(OMe) originates from this reaction.
Overview of breast cancer collaborative stage data items—their definitions, quality, usage, and clinical implications: A review of SEER data for 2004‐2010
Authors: Howlader Nadia , Chen Vivien W. , Ries Lynn A. G. , Loch Michelle M. , Lee Richard , DeSantis Carol , Lin Chun Chieh , Ruhl Jennifer , Cronin Kathleen A. 
Published: November 2014

BACKGROUNDSurveillance, Epidemiology, and End Results (SEER) Program registries began collecting new data items, known as site‐specific factors (SSFs), related to breast cancer treatment, prediction, and prognosis under the Collaborative Stage version 2 (CSv2) Data Collection System for cases diagnosed in 2010. The objectives of this report are to: 1) assess the completeness of the new SSFs and discuss their limitations and 2) discuss key changes in American Joint Committee on Cancer (AJCC) staging between the 6th and 7th editions.METHODSWe used data from the 18 SEER population‐based registries (SEER‐18), which included 71,983 women diagnosed with breast cancer in 2010.RESULTSOf the 18 SSFs examined in this study, 6 SSFs were more than 75% complete. Information on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), was available for more than 90% of the invasive breast cancer cases. These data are required to categorize the distinct subtypes of breast cancer. The majority of cases also had information on other prognostic factors such as Bloom‐Richardson score/grade (83%) and the size of invasive component in the tumor (76%). As a result of changes in staging criteria, nearly 10% of cases categorized as stage IIA according to the 6th edition of the AJCC staging manual were downstaged to stage IB under the 7th edition.CONCLUSIONSThe Collaborative Stage data collection system enables registries to collect current, relevant, and standardized data items that are consistent with the evolving view of breast cancer as a heterogeneous disease. Cancer 2014;120(23 suppl):3771‐80. © 2014 American Cancer Society.
Phase 1, open‐label, dose escalation, safety, and pharmacokinetics study of ME‐344 as a single agent in patients with refractory solid tumors
Authors: Bendell Johanna C. , Patel Manish R. , Infante Jeffrey R. , Kurkjian Carla D. , Jones Suzanne F. , Pant Shubham , Burris Howard A. , Moreno Ofir , Esquibel Vanessa , Levin Wendy , Moore Kathleen N. 
Published: November 2014

BACKGROUNDThe current phase 1, open‐label, dose escalation study was conducted to establish the safety, tolerability, pharmacokinetic profile, and preliminary antitumor activity of the novel mitochondrial inhibitor ME‐344 in patients with refractory solid tumors.METHODSPatients with refractory solid tumors were treated in a 3 + 3 dose escalation design. ME‐344 was administered via intravenous infusion on days 1, 8, and 15 of the first 28‐day cycle and weekly thereafter. Pharmacokinetics was assessed on days 1 and 15 of the first cycle.RESULTSA total of 30 patients (median age, 65 years; 67% of whom were female) received ME‐344. There were 5 dose‐limiting toxicities reported. Four patients developed grade 3 neuropathy (2 patients each at doses of 15 mg/kg and 20 mg/kg) and 1 patient treated at a dose of 10 mg/kg developed a grade 3 acute myocardial infarction (toxicity was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.03]). The maximum tolerated dose (MTD) was defined as 10 mg/kg weekly. The most common adverse events were nausea, dizziness, and fatigue. At the MTD of 10 mg/kg, the maximal plasma concentration (Cmax) was 25.8 µg/mL and the area under the concentration curve from time zero to infinity was 25.9 hour*µg/mL. One patient with small cell lung cancer achieved a partial response for ≥52 weeks. Four patients had prolonged stable disease (1 patient each with urothelial carcinoma [47 weeks], carcinoid tumor [≥40 weeks], cervical leiomyosarcoma [39 weeks], and cervical cancer [≥31 weeks]).CONCLUSIONSThe once‐weekly administration of ME‐344 was generally well tolerated in the current study, a first‐in‐human study; dose‐limiting neuropathy was noted, but not at the MTD. Exposures at the 10‐mg/kg dose level suggest a sufficient therapeutic index. The preliminary clinical activity as a monotherapy supports the further clinical development of ME‐344 in combination with chemotherapy. Cancer 2015;121:1056–1063. © 2014 American Cancer Society.
Modeling privacy issues in distributed enterprise resource planning systems
Authors: Misra Subhas Chandra , Singh Virender , Jha Naveen Kumar , Bisui Sandip 
Published: November 2014

SummaryWith extensive usage and dependence on communication networks, ‘privacy’ issues in enterprise distributed systems have become fundamentally important. Privacy concerns have flooded the market especially in the public domain, and with the changing environment of software usage and involvement of malicious substances associated with any network, it becomes essential to safeguard and ascertain privacy among users and incorporate the same safeguard to protect privacy in software as well. The methodologies and tools architecting distributed enterprise resource planning (ERP) systems are primarily new and are vulnerable to malicious attacks. This paper aims at identifying some of critical privacy issues by collecting data from ERP practitioners. This work models variables associated with ERP with the variables of privacy to establish a robust adoption of ERP practices. Privacy issues concerning ERP are listed. Several variables associated with the development, implementation, and control of ERP are identified in the existing literature. A questionnaire instrument was distributed among a set of ERP practitioners. The response data collected thereby were analyzed statistically. Based upon the statistical analysis, an attempt has been made in the paper to make a ranking of the privacy factors. The observations are discussed in detail, and some specific conclusions have been made. Copyright © 2014 John Wiley & Sons, Ltd.
Ischemic necrosis of the femoral head: An experimental rabbit model
Authors: Tudisco Cosimo , Botti Flavia , Bisicchia Salvatore , Ippolito Ernesto 
Published: November 2014

ABSTRACTTo describe the morphology of the proximal femoral epiphysis in a rabbit model from the ischemic insult to the end of the revascularization process. Ischemia of the femoral head was induced in 32 rabbits at the 8th day of life, by sectioning the joint capsule and the ligamentum teres and dislocating the femoral head. Rabbits were sacrificed at 4, 8, 12, 18, 21, 26, 34, and 48 days after surgery and femoral heads were observed histologically. During the first days following the ischemic injury, large areas underwent necrotic changes. Both epiphyseal and physeal cartilage were thicker than normal and less trabecular bone formation was evident. Bone marrow was also diffusely necrotic within the secondary center of ossification. After day 12th, reparative process started with formation of extensive areas of fibrocartilage and several secondary centers of ossifications. At that stage femoral head deformity was already evident. In the following days the secondary centers of ossification cohalesced and epiphyseal and physeal cartilage resumed a normal appearance, but the femur showed a permanent deformity. In newborn rabbits, the ischemic injury to the femoral head blocked the ossification of the epiphyseal and physeal cartilage associated to necrotic bone marrow within the secondary center of ossification of the femoral head as well as to extensive areas of necrosis of epiphyseal and physeal cartilage. Extensive areas of fibrocartilage and small newly formed ossification centers within the femoral epiphysis were the results of the revascularization process, and femoral head deformity became stable afterward. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:535–541, 2015.
Vegetation and environments since the Last Glacial Maximum in the Southern Tablelands, New South Wales
Authors: KEMP JUSTINE , HOPE GEOFF 
Published: November 2014

ABSTRACTRegional changes in vegetation and environment in the last 16 ka have been reconstructed from Micalong Swamp and Willigobung Swamp (35°S) on the western Southern Tablelands of New South Wales (NSW). Micalong Swamp lies at 980 m above sea level (a.s.l.), which is close to the subalpine treeline at this latitude. Willigobung Swamp (780 m a.s.l.) approaches the modern ecotone between dry and wet montane forest formations. The sites are sensitive to shifts in temperature and precipitation and are the first reported pollen records from the western montane slopes of NSW. A radiocarbon‐based chronology indicates that Micalong Swamp was a swampy, gravel floodplain surrounded by alpine grassland before 16.1 ka. Subalpine woodland may have become established at 1000 m by 16–14 ka. Organic fen sedimentation developed <11.8 ka at Willigobung, and ∼11.7 ka at the higher elevation Micalong Swamp. Wet forest elements were present at both sites around 10 ka and persisted for 3–4 ka. Sedimentation in a shallow lake or fen between 10 and 8 ka supports this evidence for wetter conditions in the early Holocene. In the late Holocene an expansion of subalpine flora between 2.7 and 0.9 ka preceded by shallow lake/fen sedimentation is consistent with regional evidence for neoglacial cooling.
Effect of homopolymer matrix on diblock copolymer grafted nanoparticle conformation and potential of mean force: A molecular simulation study
Authors: Estridge Carla E. , Jayaraman Arthi 
Published: November 2014

ABSTRACTWe study the effect of homopolymer A or B matrix on the conformations and effective interactions of AB diblock copolymer grafted particles using coarse‐grained molecular dynamics simulations. In an A homopolymer matrix we observe patchy conformations within the AB diblock copolymer grafted layer, where the number of B patches is controlled by the A‐A attractive interaction strength. In a B homopolymer matrix the grafted particle takes on a core‐corona conformation, where the inner A block aggregates near the particle surface and the outer B block forms a corona that interacts with the B matrix. The potential of mean force (PMF) between two particles in an A homopolymer matrix has a long‐ranged attractive well with a minima at intermediate distances corresponding to the location of the outer B block patches. The PMF between two particles in a B homopolymer matrix has an attractive well at short interparticle distances corresponding to the size of the inner A block. We isolate the contribution of the homopolymer matrix on the PMF between the two diblock copolymer grafted particles, by deducting the PMF in the absence of a matrix, assuming the contributions of the grafted particle and matrix to the PMF to be additive. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 76–88
Numerical investigation of nanoscale SiGe DG MOSFET performance against the interfacial defects
Authors: Bentrcia Toufik , Djeffal Fayçal , Dibi Zouhir , Arar Djemai 
Published: November 2014

AbstractThe SiGe‐based alloy is considered as one of the most promising materials for reliable and high performance microelectronic devices. The use of a lower band‐gap material in the channel region of the MOSFET, such as SiGe, is a potential candidate given their compatibility with the process developed for pure Si‐based devices. Moreover, the important increasing in the drain current due to the increased electrons mobility in SiGe material is expected. However, the growth of this material is not totally controlled, and the presence of defects is more than expected after a growth run of this material. Therefore, in order to obtain a global view of SiGe‐based nanoscale Double Gate (DG) MOSFET performance under critical conditions, numerical modeling of nanoscale SiGe DG MOSFET including Interfacial defect effects (SiGe/Si) is indispensable for the comprehension of the fundamentals of such device characteristics. Based on numerical investigation of a nanoscale SiGe DG MOSFET, including the defects in the interface region, in the present paper a numerical model for I‐V and small signal characteristics by including the interfacial defects, after considering the uniform function approximation for the interface defects distribution at the drain side, is developed to explain the immunity behavior of the nanoscale SiGe‐based transistor against the defect densities. In this context, DC and RF characteristics of the proposed design are analyzed by 2‐D numerical simulation and compared with conventional Si DG MOSFET characteristics. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Comparative study of defect evolution in carbon implanted strained SiGe and SiSn layers
Authors: Gaiduk Peter I. , Lundsgaard Hansen John , Nylandsted Larsen Arne , Skorupa Wolfgang 
Published: November 2014

AbstractBy combining secondary ion‐mass spectrometry, transmission‐electron microscopy (TEM) and Rutherford‐backscattering spectrometry we show that the redistribution of implanted carbon atoms around epitaxially strained Si/SiGe layers results in their accumulation on the Si side and depletion on the SiGe side. On the contrary, uphill diffusion of carbon into SiSn layers takes place in the case of Si/SiSn structures. The TEM study demonstrates formation of dislocation loops, stacking faults and interstitial clusters in the Si/SiGe layers, but elimination of interstitial dislocation loops and suppression of tin precipitates in the Si/SiSn layers. We deduced different evolution of dislocation loops and a precipitate is due to dopant‐defect complexes. The complex formation is enhanced by separation of implanted point defects in strain‐fields of Si/SiSn and Si/SiGe layers. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)