bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world analysis of the underdiagnosis, clinical outcomes and associated burden of hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) in the United States
Authors: Wang Yan , Rava Andrew , Smurzynski Marlene , Shah Bonny , Thanataveerat Anusorn , Al-Dakkak Imad , Ong Moh-Lim , Dvorak Christopher C. , Ho Vincent T. 
Published: July 2024

BackgroundThrombotic microangiopathy (TMA) associated with hematopoietic stem cell transplantation (HSCT-TMA) is a serious post-transplant complication. Diagnosis is difficult due to overlapping symptoms with other conditions and a lack of universally adopted diagnostic criteria.MethodsThis retrospective, observational study investigated HSCT-TMA incidence between July 2009–August 2020 using the TriNetX US Electronic Medical Record database. Patients who underwent autologous or allogeneic HSCT procedures and had conditioning agents were stratified as follows: confirmed TMA (≥1 hemolytic uremic syndrome (HUS)/TMA diagnosis code), suspected TMA [no HUS/TMA code but met modified published Cho (adult) or Jodele (pediatric) diagnostic criteria (further information in main text), and non-TMA (met neither criteria). Baseline demographics, clinical characteristics and outcomes, and all-cause unadjusted healthcare resource utilization (HCRU) within 12-months of HSCT, were assessed. Statistical comparisons were against the non-TMA cohort (p&lt;0.05).ResultsThe study included 16,809 adults and 901 pediatrics. Of these, 125 adults (0.7%) and 30 pediatrics (3.3%) had confirmed TMA, 3029 (18.0%) adults and 94 (10.4%) pediatrics had suspected TMA; 13,655 (81.2%) adults and 777 (86.2%) pediatrics met non-TMA criteria. Confirmed and suspected TMA incidences were higher after allogeneic HSCT in adults. In pediatrics, confirmed TMA incidence was higher following autologous transplantation, and suspected TMA higher after allogeneic transplantation. Confirmed and suspected TMA patients had significantly higher Charlson Comorbidity Indexes pre-HSCT and more post-HSCT complications. In adults with confirmed and suspected TMA, mortality estimates within 12-months of HSCT were significantly higher compared to non-TMA patients, and numerically higher in pediatrics. All confirmed and suspected TMA patients had significantly more ER visits, inpatient stays and ICU admissions. HCRU within 12-months of HSCT was higher in all confirmed TMA patients; ≤0.1% of patients with suspected TMA, and 25.6–50.0% of patients with confirmed TMA, received complement inhibitors.ConclusionsOur results demonstrate that incidence of HSCT-TMA in the real world, as per billing codes, is low compared with historical literature. However, a proportion of suspected TMA cases, based on diagnosis criteria, share similarly poor outcomes and HCRU. HSCT-TMA is likely underdiagnosed, or under-coded, in real world practice. Our study highlights the need for greater vigilance to this severe complication.
5′-UMP inhibited muscle atrophy due to detraining: a randomized, double-blinded, placebo-controlled, parallel-group comparative study
Authors: Inoue Mika , Kubota Atsushi , Takazawa Yuji , Nakagawara Kosuke , Ishige Kazuya , Suzuki Yoshio 
Published: July 2024

PurposeA short period of disuse of 1–2 weeks due to factors such as illness or injury can lead to muscle atrophy, affecting both athletic performance and health. Recent research has shown that uridine 5′-monophosphate (5′-UMP) can counteract disuse-induced muscle atrophy by increasing PGC-1α expression and inhibiting atrogin-1 expression. However, the effect of 5′-UMP on disuse muscle atrophy in humans remains unknown. Therefore, the aimed of this study was to explore the effects of 5′-UMP supplementation during detraining on short-term disuse muscle atrophy in healthy men.MethodsFollowing a 6-week resistance training program on upper arm, healthy men were randomized to either a UMP group (n = 11) or a placebo group (n = 10), taking their respective supplements during the 2-week detraining period. Muscle thickness, an indicator of muscle hypertrophy and atrophy, was measured at 3 positions (MT50, MT60, and MT70) at baseline, 1 week, and 2 weeks after detraining.ResultsBoth groups showed a significant decrease in muscle thickness at MT70. The relative decrease was greater in the placebo group (2.4 ± 2.8%) than in the UMP group (0.0 ± 2.0%), significantly (p = 0.034) at 1 week. However, no significant difference was observed at MT50 and MT60.ConclusionAfter the hypertrophy, 5′-UMP may prevent muscle atrophy due to the detraining within the first week.
Impact of Preoperative Gum Chewing on Postoperative Anti-Emetic Use in Robot-Assisted Laparoscopic Surgery for Benign Ovarian Masses: A Prospective, Single-Blinded Randomized Controlled Trial
Authors: Chae Min Suk , Lee Subin , Choi Youn Jin , Koh Hyun Jung 
Published: July 2024

Background and Objectives: Postoperative nausea and vomiting (PONV) is a common issue for females undergoing gynecological surgeries, including those assisted by robotic systems. Despite available prophylactic measures, the incidence of PONV remains high, negatively impacting recovery and increasing healthcare costs. This study evaluates whether preoperative gum chewing reduces the need for anti-emetic drugs in females undergoing robot-assisted laparoscopic surgery for benign ovarian mass. Materials and Methods: This prospective, single-blinded, randomized controlled trial enrolled 92 adult females scheduled for robot-assisted laparoscopic surgery to treat benign ovarian mass. Following exclusions, the remaining participants were randomly assigned to either a gum-chewing group or a no-gum-chewing group. The gum-chewing group chewed sugar-free gum for 15 min in the holding area before surgery. The primary outcome measured was the need for anti-emetics to control PONV during the first hour in the post-anesthesia care unit (PACU). Secondary outcomes included the number of anti-emetic requests. No preemptive anti-emetics were administered during surgery. Results: Out of the initial 92 patients, 88 were included in the final analysis, with 44 in each group. The incidence of PONV requiring anti-emetics in the PACU was significantly lower in the gum-chewing group (79.5%) compared to the no-gum-chewing group (95.5%). Additionally, the number of anti-emetic requests was higher in the no-gum-chewing group. No postoperative complications such as tooth or jaw pain/injury or gastric content regurgitation were reported. Conclusions: Preoperative gum chewing for 15 min immediately before surgery significantly reduced the incidence of PONV in females undergoing robot-assisted laparoscopic surgery for benign ovarian mass. This simple, non-pharmacological intervention improved patient comfort and reduced the need for anti-emetic medications without any adverse effects. Further studies are needed to confirm these findings and to develop guidelines for incorporating preoperative gum chewing into clinical practice.
Extraction of Astaxanthin from Haematococcus pluvialis and Preparation of Astaxanthin Liposomes
Authors: Luo Fei , Wang Shuai , Zhang Xuwu , Liu Zhiwei , Zhu Ruiyan , Xue Weili 
Published: July 2024

Astaxanthin has 550 times more antioxidant activity than vitamin E, so it can scavenge free radicals in vivo and improve body immunity. However, the poor stability of astaxanthin becomes a bottleneck problem that limits its application. Herein, Haematococcus pluvialis (H. pluvialis) as a raw material was used to extract astaxanthin, and the optimal extraction conditions included the extraction solvent (EA:EtOH = 1:6, v/v), extraction temperature (60 °C), and extraction time (70 min). The extracted astaxanthin was then loaded using lecithin to form corresponding liposomes via the ethanol injection method. The results showed that the particle size and zeta potential of the prepared liposomes were 105.8 ± 1.2 nm and −38.0 ± 1.7 mV, respectively, and the encapsulation efficiency of astaxanthin in liposomes was 88.83%. More importantly, the stability of astaxanthin was significantly improved after being embedded in the prepared liposomes.
Plasmapheresis in ANCA-Associated Vasculitis with Active Kidney Involvement in the United States (2016–2020): A Cross-Sectional Study
Authors: Tao Jianling , Yasui Osamu Winget , Kamdar Neil S. , Zheng Sijie , Popat Rita A. , Rehkopf David H. , Chertow Glenn M. 
Published: July 2024

Key Points

Plasmapheresis is recommended for treating ANCA-associated vasculitis with severe renal and/or lung involvement.We established the cohort being admitted for ANCA-associated vasculitis with active kidney involvement from the 2016–2020 National Inpatient Sample.We described characteristics, inpatient procedures, lengths of stay, hospital costs, and disposition for patients treated with plasmapheresis.

Background
Plasmapheresis is currently recommended when ANCA-associated vasculitis (AAV) presents with severe kidney and/or lung involvement. This cross-sectional study aimed at describing characteristics of hospitalized patients diagnosed with AAV with severe kidney involvement undergoing plasmapheresis in the United States.

Methods
We defined the study population as adults hospitalized for active kidney involvement with a new diagnosis of AAV (by subtype or unspecified). We established the cohort from the 2016–2020 National Inpatient Sample by International Classification of Diseases, Tenth Revision, Clinical Modification codes. In this cross-sectional study, we described demographic and clinical characteristics, associated inpatient procedures, lengths of stay, hospital costs, and disposition at discharge comparing patients treated and not treated with plasmapheresis.

Results
We identified a total of 975 patients with hospitalized AAV with acute kidney involvement in the United States treated by plasmapheresis over the 5-year period. Demographic characteristics of patients who received plasmapheresis were similar to those in patients who did not (n=5670). There were no regional differences in the proportion of patients who received plasmapheresis; however, plasmapheresis was deployed more frequently among patients admitted to urban teaching hospitals relative to rural and non-teaching hospitals. Patients treated with plasmapheresis were more likely to have had AKI (96% versus 90%, P = 0.0007), AKI requiring dialysis (52% versus 16%, P < 0.001), hypoxia (40% versus 16%, P < 0.0001), and respiratory failure requiring mechanical ventilation (13% versus 3%, P = 0.0003).

Conclusions
During 2016–2020, plasmapheresis was deployed in approximately 20% of patients being admitted for AAV and acute kidney involvement in the United States. As standards of care and practice evolve, the role of plasmapheresis in the management of AAV with acute kidney involvement will require further study.
Prosthodontics of Postoperative Defects of the Maxillary Sinus in the Early Period
Authors: Петражицкая Г.В. , Шевела Т.Л. , Можейко С.Г. 
Published: July 2024

Цель. Повысить эффективность послеоперационного лечения пациентов с дефектами верхнечелюстной пазухи путем изготовления непосредственного протеза. Материалы и методы. Обследование и протезирование пациентов проводилось на базе государственного учреждения «Университетская стоматологическая клиника» и государственного учреждения «Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова». В исследовании приняли участие 10 пациентов, которым было проведено протезирование с фиксацией непосредственного протеза на операционном столе после удаления новообразования. Результаты. В результате проведенного непосредственного протезирования у пациента не только осуществляется разграничение полости рта и носа с изоляцией ороназального и оросинусального сообщения, что, в свою очередь, обеспечивает возможность парентерального приема пищи без установки назогастрального зонда, но и восстанавливается высота нижней трети лица, жевательная функция, эстетика лица, что обусловлено наличием в протезе искусственных зубов. Заключение. На сегодняшний день не разработаны общие методы протезирования в послеоперационном периоде, нет единого мнения о сроках протезирования, по-прежнему остается много спорных и неразрешенных вопросов, требующих дальнейшей разработки и изучения относительно строения ортопедической конструкции, замещающей дефект верхнечелюстной пазухи и верхней челюсти в непосредственном, раннем и отдаленном периоде.
Purpose. To increase the effectiveness of postoperative treatment of patients with defects of the maxillary sinus by manufacturing an immediate prosthesis. Materials and methods. A clinical examination of patients was carried out on the basis of the State Institution "The University Dental Clinic" and the State Institution "N.N. Alexandrov National Cancer Centre of Belarus". The study involved 10 patients who had prosthetics with fixation of the immediate prosthesis on the operating table after removal of the neoplasm. Results. As a result of immediate prosthetics, patients undergo a separation of the oral and nasal cavities with isolation of oronasal and orosinusal communication, which, in its turn, provides the possibility of parenteral food intake without a nasogastric tube, but also regains the height of the lower third of the face, chewing function, facial aesthetics, which is due to artificial teeth in the prosthesis. Conclusion. To date, no general methods of prosthetics in the postoperative period have been developed, there is no consensus on the timing of prosthetics, and there are still many controversial and unresolved issues about the prosthetic structure replacing the defect of the maxillary sinus and maxilla in the immediate, early and distant period, requiring further development and investigation.
Kesalahan Siswa Kelas IV Sekolah Dasar Negeri 2 Bacem dalam Pemecahan Masalah Matematika Materi Luas dan Keliling Segitiga
Authors: - Adilya Wahyu Ningtyas , Subakti Ervina Eka , Cahyadi Fajar 
Published: July 2024

Penelitian ini berdasarkan pada kejadian dilapangan yaitu rendahnya hasil belajar siswa pada mata pelajaran matematika, yang disebabkan oleh kesulitan belajar dalam menyelesaikan soal cerita matematika materi luas dan keliling segitiga. Sehingga hasil tes kemampuan siswa dalam mengerjakan soal pemecahan masalah matematika rendah. Hal ini disebabkan karena banyak siswa yang belum memahami inti kalimat dari soal cerita matematika. Penelitian ini bertujuan untuk mengetahui jenis kesalahan yang dialami siswa kelas IV SDN 2 Bacem. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif. Subjek dari penelitian ini siswa kelas IV SDN 2 Bacem yang berjumlah 20 siswa. Data penelitian ini diperoleh melalui analisis tes kemampuan siswa, hasil analisis yang diperoleh adalah siswa mengalami kesulitan dan kesalahan dalam menyelesaikan soal pemecahan masalah matematika materi keliling dan luas segitiga yaitu 1) 44% siswa belum mampu memahami dan merumuskan masalah dalam soal; 2) 46% siswa masih melakukan kesalahan dalam membuat rencana pemecahan masalah untuk menentukan strategi dalam memecahkan masalah matematika; 3) 52% siswa masih melakukan kesalahan dalam pelaksanaan strategi pemecahan masalah matematika. 4) 70% siswa melakukan kesalahan dalam melihat kembali hasil pekerjaannya dalam menyelesaikan soal pemecahan masalah matematika.
EVALUASI APLIKASI MOBILE DESAIN MENGGUNAKAN METODE NIELSEN’S ATTRIBUTES OF USABILITY
Authors: Hulliya Khadijah , Amanda Aliza Fatha 
Published: July 2024

Untuk mencapai standar perangkat lunak yang baik, diperlukan pengujian kualitas perangkat lunak, termasuk usability. Salah satu faktor yang menentukan kualitas perangkat lunak adalah kemudahan penggunaan. Pada penelitian ini penulis melakukan penelitian pada aplikasi Canva. Aplikasi ini sudah di unduh sebanyak 100 juta kali oleh pengguna di google playstore. Pada penelitian ini, penulis menggunakan metode usability testing. Data yang digunakan pada penelitian ini diperoleh melalui kuesioner dan studi literatur. Tujuan dilakukan penelitian ini adalah untuk mengetahui hasil dari evaluasi usability pada aplikasi Canva. Data diperoleh melalui penelitian literatur dan kuesioner Nielsen tentang fitur usability. Penggunaan metode kuesioner Nielsen's Usability Attributes, yang terdapat lima indikator: Learnability (mudah untuk dipelajari), Efficiency (efisien), Memorability (mudah diingat), Errors (kegagalan), dan Satisfaction (kepuasan), tujuan penelitian ini adalah untuk mengetahui hasil evaluasi usability pada aplikasi Canva. Pengujian dengan metode NAU memberikan hasil rata-rata 4.02 (Setuju) dari skala penilaian 5 (Sangat Setuju). Artinya, pengguna setuju bahwa fungsinya berjalan dengan baik.
PENERAPAN FUZZY ASSOCIATIVE MEMORY UNTUK MENGUKUR TINGKAT KEPUASAN PELANGGAN TERHADAP PELAYANAN PADA TOKO KOPIMA
Authors: Wakhidah Nur , Febriani Ira Nurul 
Published: July 2024

Salah satu keuntungan adanya teknologi informasi dalam bidang usaha yaitu dapat membantu dalam mengukur tingkat kepuasan pelanggan. Karena pengukuran kepuasan pelanggan merupakan elemen penting dalam menyediakan pelayanan yang lebih baik, lebih efisien dan lebih efektif. Toko KOPIMA yang merupakan koperasi mahasiswa mengalami kendala penjualan yang tidak stabil, hal ini akibat dari ketidakpuasan pelanggan. Adanya sistem untuk mengukur tingkat kepuasan pelanggan terhadap pelayanan di toko KOPIMA untuk mengetahui apa saja harapan keluhaan pelanggan dan bagaimana penilaian terhadap pelayanan di toko KOPIMA. Untuk mengukur tingkat kepuasan pelanggan terhadap pelayanan di toko KOPIMA menerapkan metode Fuzzy Associative Memory (FAM). FAM adalah metode pengambilan keputusan yang fleksibel, merupakan suatu sistem fuzzy yang memetakan himpunan fuzzy ke himpunan fuzzy lainnya. Output yang diperoleh adalah sistem berbasis web, dengan hasil metode FAM dapat diimplementasikan untuk menghitung kepuasan pelanggan ke dalam kategori penilaian yaitu puas 8% dan sangat puas 92% pada penilaian bulan November 2022 dan penilaian bulan Desember 2022 yaitu puas 4% dan sangat puas 96%. Jadi dapat disimpulkan, kepuasan pelanggan mengalami peningkatan dengan kriteria penilaian sangat puas dengan pelayanan di toko KOPIMA.
ANALISIS FAKTOR YANG MEMPENGARUHI PEMILIHAN GUBERNUR DAERAH KHUSUS JAKARTA MENGGUNAKAN ALGORITMA NAIVE BAYES DAN REGRESI LOGISTIK
Authors: Khoiril Umat Yoga Nanda , Rusyda Nafsyi Dhiaz , Kusumaningsih Diana , Hakim Lukman 
Published: July 2024

Pemilihan Gubernur dan Wakil Gubernur Daerah Khusus Jakarta (DKJ) tahun 2024 melibatkan masyarakat dalam menentukan pemimpin untuk periode 2024-2029. Penelitian ini bertujuan menganalisis faktor-faktor yang mempengaruhi keputusan pemilih menggunakan algoritma Naive Bayes dan Regresi Logistik. Data survei dikumpulkan melalui kuesioner Google Form dari masyarakat Jakarta yang berusia 17-71 tahun. Proses analisis melibatkan beberapa tahapan, yaitu identifikasi masalah, studi literatur, pengumpulan data, preprocessing, serta pembagian data menjadi data latih dan data uji. Algoritma Naive Bayes digunakan untuk memprediksi parameter klasifikasi berdasarkan pendidikan, popularitas, dan rekam jejak calon, sementara Regresi Logistik memprediksi faktor yang mempengaruhi keputusan pemilih. Naive Bayes menunjukkan akurasi tinggi dengan keunggulan dalam kecepatan dan pengolahan data berukuran besar, sementara Regresi Logistik menunjukkan kekuatan dalam analisis klasifikasi biner dan multinomial. Hasil penelitian menunjukkan bahwa faktor rekam jejak memiliki pengaruh signifikan terhadap keputusan pemilih. Akurasi prediksi Naive Bayes mencapai 85,00% dan Regresi Logistik 80,00%. Hasil analisis juga mengungkapkan bahwa faktor popularitas dan pendidikan calon memiliki pengaruh rasional terhadap keputusan pemilih, meskipun tidak sekuat rekam jejak. Selain itu, penggunaan dua algoritma ini memberikan pandangan yang komprehensif dalam memahami perilaku pemilih di Jakarta. Berdasarkan hasil yang ada, dapat disimpulkan bahwa calon gubernur dan wakil gubernur juga bisa berfokus pada peningkatan rekam jejak dan popularitas mereka untuk meningkatkan peluang terpilih.
ETYMOLOGY OF THE CULTURAL NAME "KOZHLYANSKAYA IGRUSHKA (TOY of the Kozhlya)" AS A LINGUISTIC INDEX OF THE ETHNOCULTURAL LANDSCAPE KURSK REGION
Authors: Малыхина Т.М. , Кузьмина А.В. 
Published: July 2024

Основой данного научного исследования является анализ одного из курских культуронимов, являющихся ярким языковым источником в плане воссоздания элементов языковой картины мира наших предков и реконструкции истории ментальности и культуры народа, населяющего древний Курский край. Использованы следующие методы исследования: описательный, сравнительно-исторический, сравнительно-сопоставительный и интерпретации. Основными источниками материала послужили академические словари русского языка, фиксирующие исторические изменения слов. В ходе этимологического анализа лексемы Кожля/Козля и соответствующего культуронима кожлянская игрушка, авторами определены особенности их лексической, морфологической и фонологической структуры; восстановлены звенья семантической эволюции указанных выше слов (от мотивировочного признака до современного лексического значения), при этом были привлечены лексические данные диалектов, удерживающих древние значения слов, материалы родственных языков (индоевропейских); доказано, что подобные слова представляют собой языковое свидетельство прошлого.
The basis of this scientific research is the analysis of one of the Kursk cultural names, which are a vivid linguistic source in terms of recreating elements of the linguistic picture of the world of our ancestors and reconstructing the history of the mentality and culture of the people inhabiting the ancient Kursk Region. The following research methods were used: descriptive, comparative-historical, comparative-comparative and interpretation. The main sources of the material were academic dictionaries of the Russian language, which record historical changes in words. During the etymological analysis of lexeme Kozhlya/Kozlya and the corresponding cultural name Kozhlyanskaya igrushka (toy of the Kozhlya),the authors determined the features of their lexical, morphological and phonological structure; restored the links of the semantic evolution of the above words (from a motivational feature to a modern lexical meaning), while using lexical data of dialects retaining ancient word meanings, materials of related languages (Indo-European); proved that such words they represent linguistic evidence of the past.