bluuebunny/crossref_metadata_2025_split huggingface dataset:
Donor Political Economies and the Pursuit of Aid Effectiveness
Authors: Dietrich Simone 
Published: November 2015

AbstractIn response to corruption and inefficient state institutions in recipient countries, some foreign aid donors outsource the delivery of aid to nonstate development actors. Other donor governments continue to support state management of aid, seeking to strengthen recipient states. These cross-donor differences can be attributed in large measure to different national orientations about the appropriate role of the state in public service delivery. Countries that place a high premium on market efficiency (for example, the United States, United Kingdom, Sweden) will outsource aid delivery in poorly governed recipient countries to improve the likelihood that aid reaches the intended beneficiaries of services. In contrast, states whose political economies emphasize a strong state in service provision (for example, France, Germany, Japan) continue to support state provision. This argument is borne out by a variety of tests, including statistical analysis of dyadic time-series cross-section aid allocation data and individual-level survey data on a cross-national sample of senior foreign aid officials. To understand different aid policies, one needs to understand the political economies of donors.
Investor Sentiment and Mutual Fund Strategies
Authors: Massa Massimo , Yadav Vijay 
Published: November 2015

AbstractWe show that mutual funds employ portfolio strategies based on market sentiment. We build a proxy for the degree of a fund’s sentiment beta (or FSB). The low-FSB funds outperform high-FSB funds, even after controlling for standard risk factors and fund characteristics. This effect is sizable and delivers a net-of-risk performance of 3.8% per year. Funds with a lower FSB follow more idiosyncratic strategies, suggesting that FSB is a deliberate, active choice of the fund manager. A sentiment contrarian strategy leads to high flows due to its superior performance, whereas a sentiment catering strategy fails to attract significant investor flows.
Anticipating the 2007–2008 Financial Crisis: Who Knew What and When Did They Know It?
Authors: Adebambo Biljana , Brockman Paul , Yan Xuemin (Sterling) 
Published: November 2015

AbstractWe examine the ability of three groups of informed market participants to anticipate the 2007–2008 financial crisis. Institutional investors and financial analysts exhibit some awareness of the impending crisis in their preference for nonfinancial stocks over financial stocks. In contrast, corporate insiders of financial firms appear to be completely unaware of the timing and extent of the financial crisis. Net purchases by managers of financial firms exceed those by managers of nonfinancial firms over the entire 2006–2008 period. Our results add considerable weight to the argument that the financial crisis was more a case of flawed judgment than flawed incentives.
Efficacy of pharmacokinetic interactions between piperonyl butoxide and albendazole against gastrointestinal nematodiasis in goats
Authors: Kumbhakar N.K. , Sanyal P.K. , Rawte D. , Kumar D. , Kerketta A.E. , Pal S. 
Published: November 2015

AbstractTo test the hypothesis that modulation of hepatic microsomal sulphoxidation and sulphonation by the cytochrome P450 inhibitor piperonyl butoxide could increase bioavailability of albendazole, the present study was undertaken to understand the pharmacokinetics of albendazole in goats at a dose of 7.5 mg kg− 1 body weight with and without co-administration with piperonyl butoxide at 63.0 mg kg− 1 body weight. Plasma albendazole sulphoxide metabolite, the anthelmintically active moiety, reached its maximum concentration of 0.322 ± 0.045 μg ml− 1 and 0.384 ± 0.013 μg ml− 1 at 18 h and 24 h after administration of albendazole alone and co-administration of albendazole with piperonyl butoxide, respectively. Analysis of the data revealed statistically increased albendazole sulphoxide levels at 24 (P < 0.001), 30 (P < 0.001) and 36 h (P < 0.01) after administration of albendazole with piperonyl butoxide, with statistically increased levels of albendazole sulphone at 24, 30 and 48 h after administration. No significance difference (P > 0.05) in values of maximum concentration (normal and calculated) could be observed between groups of goats. However, values of time to reach the concentration maximum (normal and calculated), area under the concentration–time curve (0–∞ and calculated), minimum residence time, distribution half-life, elimination half-life and total area under the first movement of plasma drug concentration–time curve were significantly higher (P < 0.05) in plasma levels of albendazole sulphoxide in goats following single oral co-administration of albendazole with piperonyl butoxide. The faecal egg count reduction and lower 95% confidence limit for the group treated with albendazole alone were 97 and 68%, while for co-administration of albendazole and piperonyl butoxide the values were 99 and 97%, respectively. The ED50 for egg hatch was 0.196, indicating suspected resistance to benzimidazole anthelmintics. The drug combination proved efficacious against an albendazole-resistant nematode parasite population in goats.
Second-harmonic generation by relativistic self-focusing of cosh-Gaussian laser beam in underdense plasma
Authors: Singh Arvinder , Gupta Naveen 
Published: November 2015

AbstractThis paper presents theoretical investigation of effect of relativistic self-focusing of cosh-Gaussian (ChG) laser beam on second-harmonic generation in an underdense plasma. Steep transverse density gradients are produced in the plasma by the electron plasma wave excited by relativistic self-focusing of ChG laser beam. The generated plasma wave interacts with the pump beam to produce its second harmonics. Following Jeffrey Wentzel Kramers Brillouin (J.W.K.B) approximation and moment theory the differential equation governing the evolution of spot size of laser beam with distance of propagation has been derived. The differential equation so obtained has been solved numerically by the Runge–Kutta method to investigate the effect of decentered parameter, intensity of laser beam as well as density of plasma on self-focusing of the ChG laser beam, and generation of its second harmonics. It has been observed that the peak intensity of the laser beam shifts in the transverse direction by changing the decentered parameter and a noticeable change is observed on focusing of the laser beam as well as on conversion efficiency of second harmonics.
Reversibility and criticality in amorphous solids
Authors: Regev Ido , Weber John , Reichhardt Charles , Dahmen Karin A. , Lookman Turab 
Published: November 2015

AbstractThe physical processes governing the onset of yield, where a material changes its shape permanently under external deformation, are not yet understood for amorphous solids that are intrinsically disordered. Here, using molecular dynamics simulations and mean-field theory, we show that at a critical strain amplitude the sizes of clusters of atoms undergoing cooperative rearrangements of displacements (avalanches) diverges. We compare this non-equilibrium critical behaviour to the prevailing concept of a ‘front depinning’ transition that has been used to describe steady-state avalanche behaviour in different materials. We explain why a depinning-like process can result in a transition from periodic to chaotic behaviour and why chaotic motion is not possible in pinned systems. These findings suggest that, at least for highly jammed amorphous systems, the irreversibility transition may be a side effect of depinning that occurs in systems where the disorder is not quenched.
Combined effects of recent Pacific cooling and Indian Ocean warming on the Asian monsoon
Authors: Ueda Hiroaki , Kamae Youichi , Hayasaki Masamitsu , Kitoh Akio , Watanabe Shigeru , Miki Yurisa , Kumai Atsuki 
Published: November 2015

AbstractRecent research indicates that the cooling trend in the tropical Pacific Ocean over the past 15 years underlies the contemporaneous hiatus in global mean temperature increase. During the hiatus, the tropical Pacific Ocean displays a La Niña-like cooling pattern while sea surface temperature (SST) in the Indian Ocean has continued to increase. This SST pattern differs from the well-known La Niña-induced basin-wide cooling across the Indian Ocean on the interannual timescale. Here, based on model experiments, we show that the SST pattern during the hiatus explains pronounced regional anomalies of rainfall in the Asian monsoon region and thermodynamic effects due to specific humidity change are secondary. Specifically, Indo-Pacific SST anomalies cause convection to intensify over the tropical western Pacific, which in turn suppresses rainfall in mid-latitude East Asia through atmospheric teleconnection. Overall, the tropical Pacific SST effect opposes and is greater than the Indian Ocean SST effect.
Ultrafast collisional ion heating by electrostatic shocks
Authors: Turrell A. E. , Sherlock M. , Rose S. J. 
Published: November 2015

AbstractHigh-intensity lasers can be used to generate shockwaves, which have found applications in nuclear fusion, proton imaging, cancer therapies and materials science. Collisionless electrostatic shocks are one type of shockwave widely studied for applications involving ion acceleration. Here we show a novel mechanism for collisionless electrostatic shocks to heat small amounts of solid density matter to temperatures of ∼keV in tens of femtoseconds. Unusually, electrons play no direct role in the heating and it is the ions that determine the heating rate. Ions are heated due to an interplay between the electric field of the shock, the local density increase during the passage of the shock and collisions between different species of ion. In simulations, these factors combine to produce rapid, localized heating of the lighter ion species. Although the heated volume is modest, this would be one of the fastest heating mechanisms discovered if demonstrated in the laboratory.
Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers
Authors: Lemmens Bennie , van Schendel Robin , Tijsterman Marcel 
Published: November 2015

AbstractFaithful DNA replication is vital to prevent disease-causing mutations, chromosomal aberrations and malignant transformation. However, accuracy conflicts with pace and flexibility and cells rely on specialized polymerases and helicases to ensure effective and timely replication of genomes that contain DNA lesions or secondary structures. If and how cells can tolerate a permanent barrier to replication is, however, unknown. Here we show that a single unresolved G-quadruplexed DNA structure can persist through multiple mitotic divisions without changing conformation. Failed replication across a G-quadruplex causes single-strand DNA gaps that give rise to DNA double-strand breaks in subsequent cell divisions, which are processed by polymerase theta (POLQ)-mediated alternative end joining. Lineage tracing experiments further reveal that persistent G-quadruplexes cause genetic heterogeneity during organ development. Our data demonstrate that a single lesion can cause multiple unique genomic rearrangements, and that alternative end joining enables cells to proliferate in the presence of mitotically inherited replication blocks.
Quantification of tumor fluorescence during intraoperative optical cancer imaging
Authors: Judy Ryan P. , Keating Jane J. , DeJesus Elizabeth M. , Jiang Jack X. , Okusanya Olugbenga T. , Nie Shuming , Holt David E. , Arlauckas Sean P. , Low Phillip S. , Delikatny E. James , Singhal Sunil 
Published: November 2015

AbstractIntraoperative optical cancer imaging is an emerging technology in which surgeons employ fluorophores to visualize tumors, identify tumor-positive margins and lymph nodes containing metastases. This study compares instrumentation to measure tumor fluorescence. Three imaging systems (Spectropen, Glomax, Flocam) measured and quantified fluorescent signal-to-background ratios (SBR) in vitro, murine xenografts, tissue phantoms and clinically. Evaluation criteria included the detection of small changes in fluorescence, sensitivity of signal detection at increasing depths and practicality of use. In vitro, spectroscopy was superior in detecting incremental differences in fluorescence than luminescence and digital imaging (Ln[SBR] = 6.8 ± 0.6, 2.4 ± 0.3, 2.6 ± 0.1, p = 0.0001). In fluorescent tumor cells, digital imaging measured higher SBRs than luminescence (6.1 ± 0.2 vs. 4.3 ± 0.4, p = 0.001). Spectroscopy was more sensitive than luminometry and digital imaging in identifying murine tumor fluorescence (SBR = 41.7 ± 11.5, 5.1 ± 1.8, 4.1 ± 0.9, p = 0.0001) and more sensitive than digital imaging at detecting fluorescence at increasing depths (SBR = 7.0 ± 3.4 vs. 2.4 ± 0.5, p = 0.03). Lastly, digital imaging was the most practical and least time-consuming. All methods detected incremental differences in fluorescence. Spectroscopy was the most sensitive for small changes in fluorescence. Digital imaging was the most practical considering its wide field of view, background noise filtering capability and sensitivity to increasing depth.
Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1
Authors: Martínez-Bonet Marta , Clemente Maria Isabel , Serramía Maria Jesús , Muñoz Eduardo , Moreno Santiago , Muñoz-Fernández Maria Ángeles 
Published: November 2015

AbstractViral reactivation from latently infected cells has become a promising therapeutic approach to eradicate HIV. Due to the complexity of the viral latency, combinations of efficient and available drugs targeting different pathways of latency are needed. In this work, we evaluated the effect of various combinations of bryostatin-1 (BRY) and novel histone deacetylase inhibitors (HDACIs) on HIV-reactivation and on cellular phenotype. The lymphocyte (J89GFP) or monocyte/macrophage (THP89GFP) latently infected cell lines were treated with BRY, panobinostat (PNB) and romidepsin (RMD) either alone or in combination. Thus, the effect on the viral reactivation was evaluated. We calculated the combination index for each drug combination; the BRY/HDACIs showed a synergistic HIV-reactivation profile in the majority of the combinations tested, whereas non-synergistic effects were observed when PNB was mixed with RMD. Indeed, the 75% effective concentrations of BRY, PNB and RMD were reduced in these combinations. Moreover, primary CD4 T cells treated with such drug combinations presented similar activation and proliferation profiles in comparison with single drug treated cells. Summing up, combinations between BRY, PNB and/or RMD presented a synergistic profile by inducing virus expression in HIV-latently infected cells, rendering these combinations an attractive novel and safe option for future clinical trials.
Messengers from the deep: Fossil wadsleyite-chromite microstructures from the Mantle Transition Zone
Authors: Satsukawa Takako , Griffin William L. , Piazolo Sandra , O’Reilly Suzanne Y. 
Published: November 2015

AbstractInvestigations of the Mantle Transition Zone (MTZ; 410–660 km deep) by deformation experiments and geophysical methods suggest that the MTZ has distinct rheological properties, but their exact cause is still unclear due to the lack of natural samples. Here we present the first direct evidence for crystal-plastic deformation by dislocation creep in the MTZ using a chromitite from the Luobusa peridotite (E. Tibet). Chromite grains show exsolution of diopside and SiO2, suggesting previous equilibration in the MTZ. Electron backscattered diffraction (EBSD) analysis reveals that olivine grains co-existing with exsolved phases inside chromite grains and occurring on chromite grain boundaries have a single pronounced crystallographic preferred orientation (CPO). This suggests that olivine preserves the CPO of a high-pressure polymorph (wadsleyite) before the high-pressure polymorph of chromite began to invert and exsolve. Chromite also shows a significant CPO. Thus, the fine-grained high-pressure phases were deformed by dislocation creep in the MTZ. Grain growth in inverted chromite produced an equilibrated microstructure during exhumation to the surface, masking at first sight its MTZ deformation history. These unique observations provide a window into the deep Earth and constraints for interpreting geophysical signals and their geodynamic implications in a geologically robust context.
CalQuo: automated, simultaneous single-cell and population-level quantification of global intracellular Ca2+ responses
Authors: Fritzsche Marco , Fernandes Ricardo A. , Colin-York Huw , Santos Ana M. , Lee Steven F. , Lagerholm B. Christoffer , Davis Simon J. , Eggeling Christian 
Published: November 2015

AbstractDetecting intracellular calcium signaling with fluorescent calcium indicator dyes is often coupled with microscopy techniques to follow the activation state of non-excitable cells, including lymphocytes. However, the analysis of global intracellular calcium responses both at the single-cell level and in large ensembles simultaneously has yet to be automated. Here, we present a new software package, CalQuo (Calcium Quantification), which allows the automated analysis and simultaneous monitoring of global fluorescent calcium reporter-based signaling responses in up to 1000 single cells per experiment, at temporal resolutions of sub-seconds to seconds. CalQuo quantifies the number and fraction of responding cells, the temporal dependence of calcium signaling and provides global and individual calcium-reporter fluorescence intensity profiles. We demonstrate the utility of the new method by comparing the calcium-based signaling responses of genetically manipulated human lymphocytic cell lines.
Quasi suppression of higher-order diffractions with inclined rectangular apertures gratings
Authors: Liu Yuwei , Zhu Xiaoli , Gao Yulin , Zhang Wenhai , Fan Quanping , Wei Lai , Yang Zuhua , Zhang Qiangqiang , Qian Feng , Chen Yong , He Weihua , Wu Yinzhong , Yan Zhuoyang , Hua Yilei , Zhao Yidong , Cui Mingqi , Qiu Rong , Zhou Weimin , Gu Yuqiu , Zhang Baohan , Xie Changqing , Cao Leifeng 
Published: November 2015

AbstractAdvances in the fundamentals and applications of diffraction gratings have received much attention. However, conventional diffraction gratings often suffer from higher-order diffraction contamination. Here, we introduce a simple and compact single optical element, named inclined rectangular aperture gratings (IRAG), for quasi suppression of higher-order diffractions. We show, both in the visible light and soft x-ray regions, that IRAG can significantly suppress higher-order diffractions with moderate diffraction efficiency. Especially, as no support strut is needed to maintain the free-standing patterns, the IRAG is highly advantageous to the extreme-ultraviolet and soft x-ray regions. The diffraction efficiency of the IRAG and the influences of fabrication constraints are also discussed. The unique quasi-single order diffraction properties of IRAG may open the door to a wide range of photonic applications.
Dynamic interplay of multidrug transporters with TolC for isoprenol tolerance in Escherichia coli
Authors: Wang Chonglong , Yang Liyang , Shah Asad Ali , Choi Eui-Sung , Kim Seon-Won 
Published: November 2015

AbstractEngineering of efflux pumps is a promising way to improve host’s tolerance to biofuels such as medium-chain alcohols (CmOHs); however, this strategy is restricted by poor understanding of the efflux pumps engaged in extrusion of solvents. In this study, several Escherichia coli mutants of multidrug transporters were evaluated for isoprenol tolerance. Susceptible phenotypes were observed in the mutants with individual deletion of six transporters, AcrD, EmrAB, MacAB, MdtBC, MdtJI and YdiM, whereas inactivation of AcrAB transporter resulted in an improved tolerance to isoprenol and other CmOHs. AcrAB is the major transporter forming tripartite transperiplasmic complex with outer membrane channel TolC for direct extrusion of toxic molecules in E. coli. The AcrAB inactivation enables to enhance TolC availability for the multidrug transporters associated with extrusion of CmOHs and increase the tolerance to CmOHs including isoprenol. It is assumed that outer membrane channel TolC plays an important role in extrusion of isoprenol and other CmOHs.
CD4+CD25+ cells in multiple myeloma related renal impairment
Authors: Huang Hongdong , Luo Yang , Liang Yumei , Long Xi-Dai , Peng Youming , Liu Zhihua , Wen Xiaojun , Jia Meng , Tian Ru , Bai Chengli , Li Cui , Dong Xiaoqun 
Published: November 2015

AbstractCD4+CD25+ cells are critical regulators in almost all of the animal models of human organ-specific autoimmune diseases, transplant rejection and allergic diseases. We aimed to explore the role of CD4+CD25+ cells in the pathogenesis of multiple myeloma (MM) related renal impairment (RI). Thirty patients with MM related RI and 30 healthy volunteers were studied. The number of CD4+CD25+ cells was examined by flow cytometry. Clinical and laboratory data were collected from each subject. Glomerular injury was assessed by histopathology. Serum IL-2, IL-4 and IL-6 were analyzed by ELISA. CD4+CD25+ cells significantly decreased in MM related RI patients compared to the controls (P<0.05). CD4+CD25+ cell number was negatively associated with blood urea nitrogen (BUN), supernatant IL-4, serum IL-6, monoclonal immunoglobulin and β2-microglobulin, as well as bone marrow plasma cell percentage and proteinuria; whereas positively associated with estimated glomerular filtration rate (eGFR) (all P < 0.05). CD4+CD25+ cells gradually decreased as the Clinic Stage increased. The number of CD4+CD25+ cells reduced in MM related RI patients and was correlated with disease severity. CD4+CD25+ cells may play an important role in the pathogenesis of MM related RI.
Optimally conductive networks in randomly dispersed CNT:graphene hybrids
Authors: Shim Wonbo , Kwon Youbin , Jeon Seung-Yeol , Yu Woong-Ryeol 
Published: November 2015

AbstractA predictive model is proposed that quantitatively describes the synergistic behavior of the electrical conductivities of CNTs and graphene in CNT:graphene hybrids. The number of CNT-to-CNT, graphene-to-graphene and graphene-to-CNT contacts is calculated assuming a random distribution of CNTs and graphene particles in the hybrids and using an orientation density function. Calculations reveal that the total number of contacts reaches a maximum at a specific composition and depends on the particle sizes of the graphene and CNTs. The hybrids, prepared using inkjet printing, are distinguished by higher electrical conductivities than that of 100% CNT or graphene at certain composition ratios. These experimental results provide strong evidence that this approach involving constituent element contacts is suitable for investigating the properties of particulate hybrid materials.