bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Topical Copper Tripeptide Complex on Wound Healing in an Irradiated Rat Model
Authors: Parker Noah P. , Ardeshirpour Farhad , Schmechel Stephen C. , Lassig Amy Anne D. 
Published: June 2013

ObjectivesTo evaluate clinical and immunohistopathological effects of topical glycyl‐histidyl‐lysine‐copper (GHK‐Cu) on in vivo irradiated rat wounds.DesignAnimal model.SettingAcademic institution.Subjects and MethodsAfter dorsal irradiation and a 28‐day recovery period, 2 × 8 cm cranially based dorsal flaps were created in Sprague‐Dawley rats. Twice daily GHK‐Cu gel (test) or aquaphilic ointment (control) was applied for 10 days. Animals were euthanized, digital images of flaps were taken, and harvested tissues were immunohistochemically stained for a vascular endothelium marker, caveolin‐1, and vascular endothelial growth factor (VEGF). Digital image analysis was used for outcome measures. Unpaired t‐tests were used for statistical analyses; significance of P <. 01 accounted for multiple comparisons.ResultsBy digital analysis of clinical images, 13 test and 10 control animals showed mean ischemic areas of 5.0 cm2 (SD = 0.9) for tests and 3.8 cm2 (SD = 1.1; P =. 011) for controls. Whole slide digitized images allowed quantification of caveolin‐1‐stained blood vessels and VEGF expression in fibroblasts at the interface of healing flaps. Caveolin‐1 analyses showed a mean of 209.0 vessels (SD = 111.1) and a mean vessel luminal area of 525.7 um2 (SD = 191.0) in tests and 207.4 vessels (SD = 109.4; P =. 973) and 422.8 um2 (SD = 109.7; P =. 118) in controls. VEGF quantified as the percentage of pixels exceeding a colorimetric threshold, with higher fractions of positive pixels indicating more intense staining, showed a mean intensity score of 0.34 (SD = 0.19) in tests and 0.54 (SD = 0.41; P =. 169) in controls.ConclusionsIrradiated dorsal rat flaps treated with topical GHK‐Cu gel demonstrated no difference in flap ischemia, blood vessel number or area, or VEGF expression compared to controls.
A New Supporting Material for Fascia Grafting during Myringoplasty: Polyglycolic Acid Sheets
Authors: Yamanaka Toshiaki , Sawai Yachiyo , Hosoi Hiroshi 
Published: June 2013

We used polyglycolic acid (PGA) sheets, a reinforcing material, as supporting devices for securing the fascia instead of fibrin glue or Gelfoam in patients with tympanic membrane (TM) perforations. PGA sheets were placed lateral to the fascia graft attached using the underlay grafting technique in 6 patients. In each case, the PGA sheet had been macerated and had merged into the fascia within 1 week of the procedure. At 2 to 3 postoperative weeks, parts of the sheet had become dehydrated and detached from the fascia, revealing a new epithelialized TM underneath. Eventually, the sheet had disappeared, and complete epithelialization had been achieved at 4 to 5 postoperative weeks, resulting in the successful closure of the perforation. The repair of TM remained stable throughout the follow‐up period of at least 6 months in all patients. These results suggest that PGA sheets have the potential to secure fascia grafts and to guide the epithelialization of new tissue.
Subfascial endoscopic perforator surgery for posterolateral perforators performed in the prone position
Authors: Kusagawa Hitoshi , Shomura Shin , Komada Takuya , Katayama Yoshihiko , Haruta Naoki 
Published: June 2013

Objectives Subfascial endoscopic perforator surgery (SEPS) is usually performed for posteromedial perforators in the supine position, but subfascial endoscopic perforator surgery for posterolateral perforators in the prone position has not been reported. Methods A 51-year-old male suffered from a venous stasis ulcer around his lateral malleolus because of reflux in the small saphenous vein and incompetent perforating veins around the ulcer. Results Stripping of the small saphenous vein and subfascial endoscopic perforator surgery utilizing screw-type ports was successfully conducted in the prone position. Conclusions: The prone position enables interruption of the posterolateral perforators, because gravity-dependent flattening of the muscles enables creation of sufficient subfascial space.
Family members’ perceptions of inpatient palliative care consult services: A qualitative study
Authors: Enguidanos Susan , Housen Patricia , Penido Marcia , Mejia Bill , Miller Julie Anne 
Published: June 2013

Background: Family members are commonly involved in end-of-life decision making and typically involved in inpatient palliative care consultations. Although much research has documented patient outcomes following inpatient palliative care consultation, little is known about family member perceptions of the consultation. Aim: The purpose of this study was to determine how inpatient palliative care consultations impacted family members’ understanding of the patient’s condition, knowledge of available care options, and decision-making ability. Design: An exploratory, qualitative study was conducted employing individual interviews among family members of seriously ill patients, recruited purposively. Interviews were conducted in person, at the hospital, or via telephone, using a semistructured protocol. Setting/participants: Family members of seriously ill patients were recruited from a nonprofit, community hospital. Results: Interviews were conducted among 23 family members. Four themes were identified and included: perceived qualities of the inpatient palliative care consultation, family readiness, impact on decision-making process, and focus on comfort and quality of life. While most comments reflected positive aspects of the inpatient palliative care consult, such as improved pain control and communication, and increased access to medical professionals and time to discuss patient conditions, some themes reflected a lack of adequate preparation for the inpatient palliative care consultation and readiness for discussing prognosis. Conclusion: Family members report discussion with the inpatient palliative care team results in improved communication and knowledge, which contributes to decision-making ability. However, palliative care consultation may be improved by developing stronger protocols for introducing palliative care and by including the attending physician in the process to preclude conflicting, inconsistent information and recommendations.
Economic Growth and Employment from 1990-2010
Authors: Anderson Bret , Braunstein Elissa 
Published: June 2013

In this article we estimate the growth elasticity of employment by gender for 160 countries during 1990-2010. We then econometrically model these elasticities to draw out the structural contexts in which gendered employment outcomes respond differently to growth, including measures of economic structure, demographic change, macroeconomic stability, global stance and policy, and income distribution and institutional development. Our investigation shows that the relative size of the service sector and the ratio of female to male labor force participation are key determinants of differences in employment elasticities by gender, creating higher elasticities for women than men. We also find that the terms of global integration, as measured by the current account balance, growth in the terms of trade, and the share of foreign direct investment in investment, are important for both female and male employment elasticities. JEL Classification: O5, F4, B54
The Financial Rate of Profit
Authors: Bakir Erdogan , Campbell Al 
Published: June 2013

This work contributes to the almost nonexistent literature on the profit rate of the financial sector. It updates the single study to include financial variables to cover the past decade, compares this profit rate to the (almost unpublished) Weisskopf and NIPA financial profit rates, compares the financial and nonfinancial sector rates, and details the procedure to construct the profit rate in the financial sector including relevant financial variables which capitalists consider to make profit-rate decisions. JEL Classification: B50, E11
The Fiscal Cliff Mythology and the Full Employment Alternative
Authors: Kaboub Fadhel 
Published: June 2013

This paper critiques the fiscal cliff mythology and the neoliberal push for economic austerity policies and sequestration of government programs. The purpose of the paper is to shift the debate to a social justice alternative that can sustain and enhance the social safety nets by implementing a full employment program that is both financially affordable and economically productive. First, the paper critically assesses the laissez-faire approach to job creation and lays out the mechanics of the job guarantee (JG) program as an alternative to the neoliberal model. Next, the paper critiques the deficit hawks’ and deficit doves’ “fiscal cliff” debate and demonstrates how the JG program can be financed according to modern money theory (MMT). Finally, the paper presents the cost estimation of the JG program for the United States to demonstrate its financial affordability and its productive capabilities. JEL Classification: B5, E5, E12, E24, J2, J3, H3, H6, O51
The Failure of Market Fundamentalism
Authors: Chester Lynne 
Published: June 2013

This paper argues that neoliberalism’s global restructuring of electricity sectors has failed to deliver its proclaimed objectives and spawned threats to economic growth, financial market stability, environmental degradation, and society’s well-being. Using the case study of Australia, the paper’s régulationist analysis reveals the short-term outcomes and longer-term consequences of this restructuring, and concludes that the paradox of this structural change is the creation of inherent risks to the accumulation process. JEL Classification: B52, D02, L94, Z18
Contact Zones
Authors: Bracarense Natália 
Published: June 2013

Development theory presupposes historical specificity, but has not appropriately dealt with historical change. This inadequacy became more evident in the 1970s when history and other social sciences experienced a paradigmatic shift incited by the “cultural turn.” Motivated by this shift, mainly its emanating concept of “contact zones,” the paper adds to the literature occupied with the directions development theory may take in order to grapple with historical change as a result of the interaction between agency and structure. JEL Classification: B41, F50, O10
New Systemic Institutional Approach for Comparative Political and Economic Analysis
Authors: Kirdina Svetlana 
Published: June 2013

The idea that modern economics is necessarily based on market capitalism continues to dominate in scientific-scholarly discourse. The objective of this article is to present institutional matrix theory, or X- and Y-theory, as an alternative systemic institutional approach to economic and political development. It puts forward some new arguments to explain “grassroots resistance” to the deep marketization in many societies and answers the question why capitalism triumphs in the West and fails everywhere else. JEL Classification: P51, B52, A13
Potassium Abnormalities in a Pediatric Intensive Care Unit
Authors: Cummings Brian M. , Macklin Eric A. , Yager Phoebe H. , Sharma Amita , Noviski Natan 
Published: June 2013

Background: Potassium abnormalities are common in critically ill patients. We describe the spectrum of potassium abnormalities in our tertiary-level pediatric intensive care unit (PICU). Methods: Retrospective observational cohort of all the patients admitted to a single-center tertiary PICU over a 1-year period. Medical records and laboratory results were obtained through a central electronic data repository. Results: A total of 512 patients had a potassium measurement. Of a total of 4484 potassium measurements, one-third had abnormal values. Hypokalemia affected 40% of the admissions. Mild hypokalemia (3-3.4 mmol/L) affected 24% of the admissions. Moderate or severe hypokalemia (K <3.0 mmol/L) affected 16% of the admissions. Hyperkalemia affected 29% of the admissions. Mild hyperkalemia (5.1-6.0 mmol/L) affected 17% of the admissions. Moderate or severe hyperkalemia (>6.0 mmol/L) affected 12%. Hemolysis affected 2% of all the samples and 24% of hyperkalemic values. On univariate analysis, severity of hypokalemia was associated with mortality (odds ratio 2.2, P = .003). Conclusions: Mild potassium abnormalities are common in the PICU. Repeating hemolyzed hyperkalemic samples may be beneficial. Guidance in monitoring frequencies of potassium abnormalities in pediatric critical care is needed.
The Prevalence and Impact of Mortality of the Acute Respiratory Distress Syndrome on Admissions of Patients With Ischemic Stroke in the United States
Authors: Rincon Fred , Maltenfort Mitchell , Dey Saugat , Ghosh Sayantani , Vibbert Matthew , Urtecho Jaqueline , Jallo Jack , Ratliff John K. , McBride John William , Bell Rodney 
Published: June 2013

Purpose: To determine the epidemiology of the acute respiratory distress syndrome (ARDS) and impact on in-hospital mortality in admissions of patients with acute ischemic stroke (AIS) in the United States. Methods: Retrospective cohort study of admissions with a diagnosis of AIS and ARDS from 1994 to 2008 identified through the Nationwide Inpatient Sample. Results: During the 15-year study period, we found 55 58 091 admissions of patients with AIS. The prevalence of ARDS in admissions of patients with AIS increased from 3% in 1994 to 4% in 2008 ( P < .001). The ARDS was more common among younger men, nonwhites, and associated with history of congestive heart failure, hypertension, chronic obstructive pulmonary disease, renal failure, chronic liver disease, systemic tissue plasminogen activator, craniotomy, angioplasty or stent, sepsis, and multiorgan failures. Mortality due to AIS and ARDS decreased from 8% in 1994 to 6% in 2008 ( P < .001) and 55% in 1994 to 45% in 2008 ( P < .001), respectively. The ARDS in AIS increased in-hospital mortality (odds ratio, 14; 95% confidence interval, 13.5-14.3). A significantly higher length of stay was seen in admissions of patients with AIS having ARDS. Conclusion: Our analysis demonstrates that ARDS is rare after AIS. Despite an overall significant reduction in mortality after AIS, ARDS carries a higher risk of death in this patient population.
Ohmic pre-drying of tomato paste
Authors: Hosainpour Adel , Darvishi Hosain , Nargesi Farzad , Fadavi Ali 
Published: June 2013

In this study, the effects of ohmic pre-drying technique on moisture ratio, drying rate, drying time, specific energy consumption, drying efficiency, and effective moisture diffusivity of tomato paste were investigated. Pre-drying experiments were carried out in an ohmic laboratory dryer at voltage gradient levels of 6, 8, 10, 12, 14, and 16 V/cm and oven at 105 ℃ and 1.0 m/s air velocity (control sample). Pre-drying was accomplished till the moisture content of the tomato paste reduced from initial moisture content of 90% (w.b.) to a safer level of 70% (w.b.). The ohmic pre-drying reduced the drying time of tomato paste by 80–97%, compared with the hot air drying. Pre-drying took place mainly in warming up, constant rate, and falling rate periods. Six available moisture-ratio models were fitted to the pre-drying data. The results showed that the Midilli et al. model is the most appropriate model for pre-drying behavior of tomato paste. The effective moisture diffusivity varied from 5.39 × 10−8 to 3.91 × 10−7m2/s with an activation energy of 2.082 (V/g.cm). Both specific energy consumption and drying efficiency were considerably enhanced by increasing voltage gradient. It was found that the specific energy consumption and drying efficiency varied from 3.72 to 2.29 MJ/kg water and 67.8 to 83.8%, respectively.
The Effects of House Bill 1355 on Voter Registration in Florida
Authors: Herron Michael C. , Smith Daniel A. 
Published: June 2013

AbstractIn mid-2011, the Florida state legislature passed House Bill 1355 (HB 1355) and in so doing placed new regulations on community organizations that historically have helped eligible Floridians register to vote. Among the legal changes promulgated by this bill were new regulations on the operations of groups like the League of Women Voters and a new oath, warning of prison time and fines, that voter registration agents were required to sign. Such changes raised the implicit costs that eligible Florida citizens faced when registering to vote, and we show that voter registrations across the state in the second half of 2011 dropped precipitously compared with registrations in the second half of 2007. This pattern is evident among registrants in general, among registrants age 20 and younger, and among individuals who registered as Democrats. Outside of HB 1355, we know of no credible explanations for these results. Our findings thus show how restrictions on the way that third-party organizations register voters can have tangible effects on actual registrations. Given that registration prior to an election is a civic necessity in Florida and in many other states, such restrictions have the potential to affect electoral outcomes as well.
Oesophageal pressure‐flow metrics in relation to bolus volume, bolus consistency, and bolus perception
Authors: Omari Taher I , Wauters Lucas , Rommel Nathalie , Kritas Stamatiki , Myers Jenifer C 
Published: June 2013

BackgroundThe utility of combined oesophageal pressure–impedance recording has been enhanced by automation of data analysis.ObjectiveTo understand how oesophageal function as measured by automated impedance manometry (AIM) pressure‐flow analysis varies with bolus characteristics and subjective perception of bolus passage.MethodsOesophageal pressure–impedance recordings of 5 and 10 ml liquid or viscous swallows and 2 and 4 cm solid swallows from 20 healthy control subjects (five male; 25–73 years) were analysed. Metrics indicative of bolus pressurization (intrabolus pressure and intrabolus pressure slope) were derived. Bolus flow resistance, the relationship between bolus pressurization and flow timing, was assessed using a pressure‐flow index. Bolus retention was assessed using the ratio of nadir impedance to peak pressure impedance (impedance ratio). Subjective perception of bolus passage was assessed swallow by swallow.ResultsViscosity increased the bolus flow resistance and reduced bolus clearance. Responses to boluses of larger volume and more viscous consistency revealed a positive correlation between bolus pressurization and oesophageal peak pressure. Flow resistance was higher in subjects who perceived bolus hold up of solids.ConclusionsBolus volume and bolus type alter oesophageal function and impact AIM analysis metrics descriptive of oesophageal function. Perception of bolus transit was associated with heightened bolus pressurization relative to bolus flow.
Prolylcarboxypeptidase promotes angiogenesis and vascular repair
Authors: Adams Gregory N. , Stavrou Evi X. , Fang Chao , Merkulova Alona , Alaiti M. Amer , Nakajima Kohsuke , Morooka Toshifumi , Merkulov Sergei , LaRusch Gretchen A. , Simon Daniel I , Jain Mukesh K. , Schmaier Alvin H. 
Published: June 2013

Key PointsPRCP influences cell growth independent of its active site. PRCP loss has reduced angiogenesis, wound healing, and ischemic/wire injury repair.
CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia
Authors: Green Margaret L. , Leisenring Wendy M. , Xie Hu , Walter Roland B. , Mielcarek Marco , Sandmaier Brenda M. , Riddell Stanley R. , Boeckh Michael 
Published: June 2013

Key Points
CMV reactivation after HCT is associated with a reduced risk of early relapse in patients with AML but not other disease groups. The benefit, however, is offset by an increased risk of nonrelapse mortality.
Transcriptional adaptation of pneumococci and human pharyngeal cells in the presence of a virus infection
Authors: Kimaro Mlacha Sheila Z , Peret Teresa C T , Kumar Nikhil , Romero-Steiner Sandra , Dunning Hotopp Julie C , Ishmael Nadeeza , Grinblat-Huse Valerie , Riley David R , Erdman Dean D , Carlone George M , Sampson Jacquelyn , Scott J Anthony G , Tettelin Hervé 
Published: June 2013

AbstractBackgroundViral upper respiratory tract infections are associated with increased colonization byStreptococcus pneumoniaebut the mechanisms underlying this relationship are unclear. The objective of this study is to describe a comprehensive picture of the cellular interaction between the adhering bacteria and host cells in the presence or absence of a viral co-infection.ResultsGene expression profiles of Detroit-562 pharyngeal cells, which were either mock-infected or infected with human respiratory syncytial virus (RSV) or human parainfluenza virus 3 (HPIV3), were analyzed using human microarrays. Transcription response ofS. pneumoniaestrain TIGR4 (serotype 4) in the presence of either mock- or viral-infected cells was analyzed by pneumococcal microarray. Significantly regulated genes were identified by both significance analysis of microarray (SAM) and a ≥ 2-fold change ratio cut-off. The adherence ofS. pneumoniaeto human pharyngeal cells was significantly augmented in the presence of RSV or HPIV3 infection. Global gene expression profiling of the host cells during infection with RSV or HPIV3 revealed increased transcription of carcinoembryonic antigen-related cell adhesion molecules (CEACAM1), CD47, fibronectin, interferon-stimulated genes and many other host cell adhesion molecules. Pneumococci increased transcription of several genes involved in adhesive functions (psaA, pilus islet), choline uptake and incorporation (licoperon), as well as transport and binding.ConclusionsWe have identified a core transcriptome that represents the basic machinery required for adherence of pneumococci to D562 cells infected or not infected with a virus. These bacterial genes and cell adhesion molecules can potentially be used to control pneumococcal adherence occurring secondary to a viral infection.
Alternative splicing tends to avoid partial removals of protein-protein interaction sites
Authors: Colantoni Alessio , Bianchi Valerio , Gherardini Pier Federico , Scalia Tomba Gianpaolo , Ausiello Gabriele , Helmer-Citterich Manuela , Ferrè Fabrizio 
Published: June 2013

Abstract

Background
Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.

Results
Using a Cochran-Mantel-Haenszel chi-square test we demonstrated that the alternative splicing-mediated partial removal of both heterodimeric and homodimeric binding sites occurs at lower frequencies than expected, and this holds true even if we consider only those isoforms whose sequence is less different from that of the canonical protein and which therefore allow to selectively regulate functional regions of the protein. On the other hand, large removals of the binding site are not significantly prevented, possibly because they are associated to drastic structural changes of the protein. The observed protection of the binding sites from AS is not preferentially directed towards putative hot spot interface residues, and is widespread to all protein functional classes.

Conclusions
Our findings indicate that protein-protein binding sites are generally protected from alternative splicing-mediated partial removals. However, some cases in which the binding site is selectively removed exist, and here we discuss one of them.