bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxicity of immune checkpoint inhibitors and tyrosine kinase inhibitor combinations in solid tumours: a systematic review and meta-analysis
Authors: O’Reilly David , O’Leary Caroline L. , Reilly Aislinn , Teo Min Yuen , O’Kane Grainne , Hendriks Lizza , Bennett Kathleen , Naidoo Jarushka 
Published: July 2024

The combination of immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) can be associated with significant toxicity. We performed a systematic review and meta-analysis of the toxicity of combination treatment of ICIs with TKIs (ICI + TKI) in clinical trials with solid organ malignancies. Our primary endpoint explored the incidence of grade 3 - 5 (G3-5) treatment-related toxicity and our secondary endpoints included the incidence of toxicity by treatment type, disease type and studies with run-in strategies. A total of 9750 abstracts were identified, of which 72 eligible studies were included. The most common disease types were non-small cell lung cancer (n=8, 11.1%), renal cell carcinoma (n=10, 13.8%) and hepatobiliary cancers (n=10, 13.8%). The overall incidence of G3-5 toxicity was 56% (95% CI = 50% – 61%). The most common TKIs combined with ICIs in this analysis were multi-targeted TKIs (n = 52, 72%), VEGF specific (n = 9, 12.5%), or oncogene-targeting TKIs (EGFR, ALK, BRAF, MEK) (n =11, 15.3%). Oncogene-targeted TKIs were associated a higher incidence of rashes and immune related adverse events (irAEs) and lower incidence of hypertension. In studies which used a TKI ‘run-in’ to mitigate toxicity, the pooled estimate of G3-5 toxicity was 71% (95% CI 57-81%). Almost half of studies (48%) omitted the incidence of G3-5 irAEs. Our work suggests that the majority of patients who receive ICI-TKI combinations will experience high grade toxicity (G3-G5) and that toxicity may be specific to TKI partner (Oncogene targeted TKIs: Rash, irAEs; VEGF/Multitargeted: Hypertension). These data did not suggest that a TKI ‘run-in’ was associated with a lower incidence of G3-5 toxicity. Reporting of irAEs was inconsistent supporting the need for harmonisation of adverse event reporting to include onset, duration and treatment.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022367416.
Association between amoxicillin administration and outcomes in critically ill patients with acute kidney injury
Authors: Luo Xinyao , Zhou Weijian , Wan Dingyuan , Peng Jing , Liao Ruoxi , Su Baihai 
Published: July 2024

PurposeThis study assessed the effect of amoxicillin on outcomes in intensive care unit (ICU) patients with acute kidney injury (AKI), focusing on mortality rates and acute kidney disease (AKD) occurrence.Materials and MethodsWe conducted a retrospective cohort analysis utilizing data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The study included intensive care unit patients diagnosed with AKI to assess the effects of post-admission amoxicillin administration on 30-day and 90-day mortality rates and acute kidney disease incidence. We employed Cox proportional hazards models, propensity score matching, and inverse probability of treatment weighting to control for potential confounders.ResultsAmong 24,650 AKI patients, 676 (2.7%) received amoxicillin. The results indicated significantly lower mortality rates at 30 days (hazard ratio [HR] 0.54, 95% confidence interval [CI] 0.42–0.69) and 90 days (HR 0.64, 95% CI 0.52–0.77) in the amoxicillin group compared to non-recipients. Additionally, amoxicillin administration was associated with a reduced incidence of AKD (HR 0.49, 95% CI 0.36–0.65) but resulted in a modestly increased length of hospital stay (mean difference [MD] 1.95 days, 95% CI 1.15–2.75). A dose‒response relationship was evident, with higher doses (&gt;875 mg) further decreasing mortality rates. Subgroup analysis revealed consistent benefits across most patient groups.ConclusionAmoxicillin administration following ICU admission in patients with AKI was associated with improved survival rates and a lower incidence of AKD, highlighting its potential as a therapeutic measure for AKI management.
Effectiveness of traditional herbal Kampo medicine Goreisan on chronic subdural hematoma recurrence: a meta-analysis
Authors: Yang Zhenyu , Zeng Yuecheng , Hu Jinyang , Huang Xin , Zhang Haiquan , Liu Yang 
Published: July 2024

Objectives: Our objective was to compare the effectiveness of Traditional Chinese herbal Kampo medicine Goreisan in improving recurrence in patients with chronic subdural hematoma (CSDH).Methods: Eligible randomized controlled trials prospective trials, and retrospective cohort studies were systematically identified through searches of PubMed, Cochrane Library, and CNKI from inception to March 2024. Following the application of predetermined inclusion and exclusion criteria to screen the available studies, main outcome measures were rigorously extracted. RevMan v5.4 software was utilized to evaluate the overall recurrence rate, employing a random-effects model to calculate pooled odds ratios with the Mantel-Haenszel estimation method. Inter-study heterogeneity was assessed using the Cochran Q (Chi-square) test and I2 statistics. Funnel plots were used to evaluate publication bias.Results: Among the 48 articles initially screened for citation, eight were ultimately selected for inclusion in the study. The results of our network meta-analysis indicate that patients with newly diagnosed Chronic subdural hematoma experienced a significantly reduced recurrence rate when treated with Goreisan compared to standard neurosurgical treatment (OR: 0.72; 95% CI 0.61–0.86; p = 0.00003). There was no statistically significant difference in the incidence rates of complications, including general fatigue, allergic reactions, hepatic dysfunction, and interstitial pneumonia (OR: 7.21; 95% CI 0.37–141.29; p = 0.19).Conclusion: Traditional medicine Goreisan was effective in reducing CDSH recurrence rates. For clinical treatment, it provides a high level of evidence-based medicine. It is also necessary to conduct multicenter randomized controlled trials with dose adjustments to determine whether Goreisan interventions improve neurological function or prognosis.
The rising use of cognitive enhancement drugs and predictors of use during COVID-19: findings from a cross-sectional survey of students and university staff in the UK
Authors: Tully Jamie L. , Bridge Oliver , Rennie Joseph , Krecké Joy , Stevens Tobias 
Published: July 2024

BackgroundThe use of psychoactive substances to increase cognitive performance while studying has been termed ‘pharmacological cognitive enhancement’ (PCE). In previous years, several large-scale national surveys have focused on their use by students at university, including drug types, prevalence rates, and predictive factors. The recent coronavirus pandemic brought about widespread structural changes for UK universities, as students were forced to adapt to home-based learning and in many cases reduced academic support. No study has yet focused primarily on the impact of pandemic social restrictions on PCE in students and academic staff, and whether personality and demographic factors reveal user profiles that predict use during the pandemic period.MethodA convenience sample of 736 UK students and staff aged 18–54 (M = 22.2, SD = 5.2) completed a cross-sectional survey assessing PCE prevalence rates, polydrug use, perceived effects, academic self-efficacy and personality during the first year of social restrictions (March 2020 – February 2021) compared with the previous year (March 2019 – February 2020).ResultsThere was a significant self-reported rise in the use of all drug types (all ps &lt; 0.001) during social restrictions, particularly with Modafinil (+42%), nutraceuticals (+30.2%) and microdose LSD (+22.2%). Respondents also indicated stronger PCE effects for all substances, except alcohol, in comparison to the previous year. Polydrug use with modafinil and other prescription stimulants increased the most during social restrictions. Personality factors and gender identity reliably predicted PCE use and lower agreeableness was often the strongest predictor, followed by identifying as male and lower conscientiousness. Academic self-efficacy and student/academic staff status were not consistent predictors.ConclusionThis is the first survey of UK students to investigate PCE during coronavirus social restrictions and to assess predictive factors. Findings reveal a rise in PCE use and polydrug use which we suggest is because of increased pressures on students created by the lockdown and reduced access to university resources.
Trajectories of mindfulness, flow experience, and stress during an online-based MBSR program: the moderating role of emotional exhaustion
Authors: Hohnemann Charlotte , Engel Florian , Peifer Corinna , Diestel Stefan 
Published: July 2024

IntroductionDespite numerous papers focusing on mindfulness at work, our knowledge about how flow experience and stress as indicators of optimal functioning and wellbeing at work evolve over time during the common mindfulness-based stress reduction (MBSR) program remains limited. Drawing from the transactional model of flow and stress, we argue that a build-up of mindfulness over the training duration not only leads to a decrease in stress but also an increase in flow experience. Thereby, we examine the moderating role of emotional exhaustion amplifying the beneficial effects of mindfulness.MethodsIn a quasi-experimental study, 91 participants completed weekly questionnaires over the course of 8 weeks. Forty six participants in the experimental group took part in the MBSR program, while 45 participants were part of an inactive control group.ResultsMindfulness and flow showed a significant linear increase over time, whereas stress exhibited a linear decrease. Those who participated in the MBSR training reported an increase in mindfulness that positively and negatively predicted the trajectories of flow and stress, respectively. Emotional exhaustion amplified the effects of the trajectory of mindfulness on the trajectories of flow and stress.DiscussionThese findings suggest that mindfulness can not only reduce stress but can also foster the autotelic experience of flow, especially for chronically depleted individuals. However, more research is necessary to replicate these results and address the limitations of the current study, including the quasi-experimental design, the use of self-report measures, as well as the dropout during the study period.
Flow and performance: a quantitative study of elicitation modeling in a piano performance perspective
Authors: Li Junrui , Xu Ying , Wang Xiaoyu , Yuan Xinran , Liu Shilin , Li Meihui , Ren Xiubo , Yang Dan , Liu Siqi , Jiang Zhenxu , Gou Qiaoqiao , Yang Miaomiao , Xu Qiujian 
Published: July 2024

IntroductionFlow, defined as a heightened state of consciousness characterized by intense concentration during an activity, is influenced primarily by the perceived challenge and the dynamic equilibrium of skills. This investigation focuses on the patterns of flow state attainment and its elicitation mechanisms within the context of piano performance among Chinese music college students.MethodsOur study establishes a framework for accessing flow, utilizing quantitative data from music ontology to gauge the level of challenge and the level of music acquisition to assess skills. Additionally, we integrate external factors such as music culture heterogeneity and demographic variables to elucidate the causes and moderating effects of flow on piano performance.ResultsThe findings reveal a positive correlation between flow and performance, with the model of challenge and skill induction partially explaining these results. Notably, melodic Shannon Entropy emerges as a potential indicator of challenge, suggesting its relevance in future studies on flow.DiscussionThis research provides multidimensional insights into the interplay between performance and flow in piano performance, guiding future investigations to explore the musical quantitative perspective more deeply.
Prevalence of parenthood among hospitalized adult patients with severe mental illness: a quantitative data analysis
Authors: Havelková Anna , Havelka David , Koros Bartošová Kateřina 
Published: July 2024

IntroductionIn the Western world, more than one-third of the patients of productive age hospitalized for severe mental illness (SMI) are parents. Each of their offspring is exposed to several stressors related to their parent’s illness and hospitalization, which puts them at an increased risk of developing mental health problems. In the Czech Republic, no statistics are currently available about the families of patients with SMI, inpatients who are parents, or data about their children (ages ≤18 years). Therefore, our research aim was to describe the prevalence of parenthood among hospitalized patients with SMI, assess the number of children and determine the extent to which offspring information was present in medical records.MethodsQuantitative data from medical records (2,768 patients, aged 18–63 years, hospitalized for SMI between 2017 and 2020) from two large inpatient psychiatric facilities were examined. Parental information, demographic characteristics, number of children, and other available data were collected.ResultsThe prevalence of parenthood among inpatients with SMI was 34.6%. Parenthood was most prevalent among female patients and patients with recurrent depressive and bipolar disorders. The total number of offspring in 957 patient-parents was 1781 (41.7% minors under the age of 18). Information on parenthood was available in 99.7% of cases; information on the age of offspring, custody, and sociodemographic situation varies, being included in 73% to 89.7% of the medical records (some details were more frequently recorded than others).DiscussionThe data obtained may help to better understand and address the specifics of these families and thus serve as a basis for the development of prevention programs.
Increased antipsychotic drug concentration in hospitalized patients with mental disorders following COVID-19 infection: a call for attention
Authors: Yang Rui , Wan Jin-Ling , Pi Chen-Qi , Wang Tian-Hui , Zhu Xue-Quan , Zhou Shuang-Jiang 
Published: July 2024

PurposeExamine the alterations in antipsychotic concentrations following coronavirus disease-2019 (COVID-19) infection among hospitalized patients with mental disorders and conduct an analysis of the factors influencing these changes.MethodsData were collected from inpatients at Beijing Huilongguan Hospital between December 12, 2022, and January 11, 2023, pre- and post-COVID-19. Based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, 329 inpatients with mental disorders were included (3 with incomplete data excluded). Primary outcomes assessed changes in antipsychotic concentrations pre- and post-COVID-19, while secondary outcomes examined factors linked to concentration increases and antipsychotic dose adjustments.ResultsClozapine (P &lt; 0.001), aripiprazole (P &lt; 0.001), quetiapine (P = 0.005), olanzapine (P &lt; 0.001), risperidone (P &lt; 0.001), and paliperidone (P &lt; 0.001) concentrations increased post-COVID-19 in patients with mental disorders. Notably, clozapine concentration surpassing pre-infection levels was highest. Clozapine users were more likely to adjust their dose (50.4%) compared to olanzapine (17.5%) and other antipsychotics. Moreover, traditional Chinese patent medicines and antibiotics during COVID-19 infection were associated with antipsychotic reduction or withdrawal (OR = 2.06, P = 0.0247; OR = 7.53, P = 0.0024, respectively).ConclusionAntipsychotic concentrations in hospitalized patients with mental disorders increased after COVID-19 infection, that may be related not only to COVID-19, but also to the use of Chinese patent medicines during infection. The pre-infection concentration and types of antipsychotics, patient’s gender, and combination of traditional Chinese medicine or antibiotics, were factors found to correlate with increased drug concentrations and necessitate dose adjustments.
Effect of cyclic meditation on anxiety and sleep quality in sailors on merchant ships—A quasi-experimental study
Authors: Paranthatta Sukesh , George Titty , Vinaya H. M. , Swathi P. S. , Pandey Mangesh , Pradhan Balaram , Babu Natesh , Saoji Apar Avinash 
Published: July 2024

BackgroundSailors undergo anxiety and sleep disturbances due to prolonged journeys and the nature of their work on ships. Earlier studies indicate Cyclic Meditation (CM) being beneficial for managing anxiety and improving sleep quality. Thus, the current study was designed to investigate the effect of CM on anxiety and sleep quality among sailors.Materials and methodsFifty sailors were assigned to experimental (n = 25) and control (n = 25) groups. The experimental group received 45 min of CM, 7 days a week for 3 weeks. Control group continued with their routine activities and were offered CM practice the following 3 weeks. Hamilton Anxiety Scale for anxiety (HAM-A) and the Pittsburg Sleep Quality Index (PSQI) for sleep along with blood pressure and pulse rate were taken at baseline and by the end of 3 weeks. Data were analyzed using Repeated Measures Analysis of Variance (RM ANOVA) for within and between group effects.ResultsSignificant differences were found between the groups following 3 weeks for all the variables. Experimental group demonstrated reduced anxiety (p &lt; 0.001) and improved sleep (p &lt; 0.001) along with improvements in blood pressure and pulse rate. The control group did not show any significant changes following 3 weeks.ConclusionCM could be incorporated as a routine for sailors to manage their anxiety and improve sleep quality during the period on board ships.
Spatial variations and determinants of receiving cash and food from the productive safety net program among households in Ethiopia: spatial clustering and multilevel analyses
Authors: Terefe Bewuketu , Muluneh Begosew , Sisay Seretew Wullo , Misganaw Geremew Bisrat 
Published: July 2024

BackgroundThere is a global struggle with food insecurity and undernutrition among women, and Ethiopia has been particularly impacted by these issues. To address this challenge, Ethiopia has implemented a cash and food safety net program over many years. However, there is limited information available regarding the program’s factors and spatial distributions, with no recent national evidence from Ethiopia. Consequently, the objective of this study is to investigate the spatial clustering and determinants of the Productive Safety Net Program (PSNP) in Ethiopia.MethodThis study utilized data from the Ethiopian Demographic and Health Survey. The sample included 8,570 weighted households. Given the hierarchical nature of the data, a multilevel logistic regression model was employed to identify factors influencing the outcome variable. Geographical clusters of individuals receiving assistance from the PSNP were examined using SaTScan software and the Bernoulli model, along with the Kulldorff methods. The nationwide distribution of the program beneficiaries was visualized using ArcGIS version 10.8. Variables were considered statistically significant if their p-value was &lt;0.05.ResultsThe overall coverage of the PSNP was 13.54% [95% confidence interval (CI): 12.84–14.29] among households in Ethiopia. The study revealed that people from richer households adjusted odds ratio [AOR = 0.46 (95% CI: (0.33, 0.64))], those from the richest households [AOR = 0.26 (95% CI:(0.17,0.41))], and those with educated household heads [AOR = 0.45 (95% CI:(0.28, 0.71))] have a lower likelihood of utilizing the PSNP compared to their counterparts. Conversely, a unit increase in household heads’ age [AOR = 1.02 (95% CI:(1.01, 1.02))] and family size [AOR = 1.05 (95% CI:1.021.10)] showed a higher likelihood of joining the PSNP, respectively. Household heads who have joined community health insurance [AOR = 3.21 (95% CI:(2.58, 4.01))] had significantly higher odds of being included in the PSNP than their counterparts. Heads who belong to a community with a high poverty level [AOR = 2.68 (95% CI:(1.51, 4.79))] and community health insurance [AOR = 2.49 (95% CI:(1.51, 4.11))] showed more inclination to utilize the PSNP compared to their counterparts.ConclusionPSNP was judged to have a low implementation status based on the findings gathered regarding it. We found factors such as age, sex, region, wealth, education, family size, regions, and health insurance to be statistically significant. Therefore, encouraging women empowerment, community-based awareness creation, and coordination with regional states is advisable.
Marginal effects of economical development and university education on China’s regular exercise population
Authors: Agudamu  , Bu Te , Zhang Yang 
Published: July 2024

ObjectiveAlthough the regular exercise population is a key metric for gaging the success of China’s fitness-for-all activities, effective policy approaches to increase mass sports participation remain unclear. Previous research suggests that GDP, educational attainment, sports resources, and meteorological conditions could influence regular exercise participation. Therefore, this study first analyzed the macro-level correlates influencing China’s regular exercise population.MethodsWe utilize ordinary least squares (OLS) regression and geographical weighted regression (GWR) to theorize the relationship. The analysis encompasses data from the 31 administrative regions of Mainland China, as reported at the end of the 13th Five-Year Plan period. The log–log model enables us to quantify the marginal effect (elasticity) of the explanatory variables.ResultsThe OLS regression showed that regional GDP and the proportion of the population with a university education were significant predictors. In the global model, the marginal effects of regional GDP and university education were 0.048 and 0.173, respectively. Furthermore, the GWR revealed a distinct geographic pattern that corresponds to the classic Hu Line.ConclusionWhile regional GDP was also a significant correlate in our model, the elasticity demonstrates that university education had an asymmetric effect on China’s regular exercise population. Therefore, this paper sheds light on a policy priority for the upcoming 15th Five-Year Plan, emphasizing the strategic importance of expanding university education to enhance mass sports participation. In turn, a better-educated populace may yield significant secondary effects on public health and contribute to the high-quality development of the Chinese path to modernization.