bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential role of pretransplant MIBG diagnostic scintigraphy in targeted administration of 131I‐MIBG accompanied by ASCT for high‐risk and relapsed neuroblastoma: A pilot study
Authors: Hamidieh Amir Ali , Beiki Davood , Paragomi Pedram , Fallahi Babak , Behfar Maryam , Fard‐Esfahani Armaghan , Hosseini Ashraf Sadat , Shamshiri Ahmadreza , Eftekhari Mohammad , Ghavamzadeh Ardeshir 
Published: May 2014

AbstractMIBG is an effective component in treatment of neuroblastoma. Furthermore, MIBG scintigraphy is an imaging modality in primary assessments. None of the previous studies have evaluated the role of pretransplant MIBG scintigraphy in decision making for neuroblastoma treatment. We selected therapeutic regimen based on pretransplant 131I‐MIBG scintigraphy. Twenty high‐risk patients were enrolled. On day −30, patients underwent diagnostic MIBG scintigraphy. Patients were then subdivided into two groups (10 cases in each arm). MIBG‐avid subgroup received MIBG (12 mCi/kg), etoposide (1200 mg/m2), carboplatin (1500 mg/m2), and melphalan (210 mg/m2). Non‐MIBG‐avid subgroup received etoposide (600 mg/m2), carboplatin (1200 mg/m2), and melphalan (150 mg/m2). Patients received CRA after ASCT. Mean age at diagnosis was 42.5 months (range, 17–65) in MIBG‐avid and 38.9 months (range, 18–65) in non‐MIBG‐avid patients. Mean age at diagnosis and transplantation did not reveal significant difference between two subgroups. In MIBG‐avid patients, the three‐yr OS was 66 ± 21%. In MIBG‐non‐avid subgroup, the three‐yr OS was 53 ± 20%. In MIBG‐avid and non‐MIBG‐avid subgroups, the three‐yr EFS were 66 ± 21% and 47 ± 19%, respectively. These findings may suggest an effective role in selecting the therapeutic strategy for pre‐ASCT MIBG scintigraphy in high‐risk neuroblastoma. MIBG‐avid subset may benefit from the combination of therapeutic MIBG and high dose of chemotherapy.
Efficacy of bortezomib for reducing donor‐specific antibodies in children and adolescents on a steroid minimization regimen
Authors: Nguyen Stephanie , Gallay Brian , Butani Lavjay 
Published: May 2014

AbstractAMR is increasingly being recognized as an important cause of renal allograft injury, contributing to significant morbidity and graft loss. There are few controlled trials and no well‐established treatment guidelines for AMR in renal transplant recipients. We retrospectively reviewed the outcome of four pediatric renal transplant recipients on a steroid minimization immunosuppression protocol treated with bortezomib for elevated DSA and acute AMR from 2012 to 2013. All patients received four doses of bortezomib 1.3 mg/m2 given on days one, four, eight, and 11. All patients also received other treatments prior to bortezomib, which may have included rituximab, methylprednisolone, plasmapheresis, and/or IVIg. While bortezomib in addition to other therapies significantly decreased DSA titers, DSA remained very elevated months after treatment. All four patients had immediate improvement or stabilization of renal function but one eventually lost her graft. There were no adverse events related to bortezomib six months after treatment.
An endobronchial inflammatory myofibroblastic tumor in a 10‐yr‐old child after allogeneic hematopoietic cell transplantation
Authors: Fujino Hisanori , Park Young‐Dong , Uemura Suguru , Tanaka Shinzo , Kawabe Masakazu , Maeda Sayaka , Kato Itaru , Watanabe Ken‐Ichiro , Umeda Katsutsugu , Hiramatsu Hidefumi , Adachi Souichi , Sato Toshihiko , Date Hiroshi , Haga Hironori , Sumimoto Shinichi 
Published: May 2014

AbstractIMTs belong to the group of soft tissue tumor and could occur at any anatomical site; however, the causes and growth feature remain unclear. This case report documents a 10‐yr‐old male suffering from slowly developing dyspnea on exertion and cough around seven months post‐HCT. He was diagnosed with an endobronchial tumor based on imaging, and histology confirmed ALK‐positive submucosal spindle‐shaped cells with infiltrative cells, compatible with IMT. We should be aware that IMT is a potential complication of pediatric allogeneic HCT and can cause sudden airway obstruction.
Scurvy: A new problem for patients with chronic GVHD involving mucous membranes; an easy problem to resolve
Authors: Kletzel Morris , Powers Kim , Hayes Meghan 
Published: May 2014

AbstractVitamin C deficiency in developed countries is typically observed in patients with unique clinical conditions such as cystic fibrosis or anorexia nervosa, or in patients on long‐term tube feeds. We report here a clinical observation in six pediatric and adolescent patients (median age 17.5 yr, range 9.8–23.5 yr) with chronic GVHD with mucous membrane involvement found to be vitamin C deficient. These patients' baseline serum vitamin C levels ranged from <0.12 to 0.94 mg/dL (normal value 0.20–1.90 mg/dL), with a mean level 0.56 ± 0.36 mg/dL and a median level 0.6 mg/dL. Among these patients, signs and symptoms of mucositis failed to respond to standard chronic GVHD therapy. After receiving treatment with 2000 mg of ascorbic acid by mouth, daily patients displayed increased serum vitamin C levels. Clinically, this correlated with a remarkable improvement in patients' mucositis and ability to eat.
The Effects of Project‐Based Learning on Students' Academic Achievement, Attitude, and Retention of Knowledge: The Subject of “Electricity in Our Lives”
Authors: Karaçalli Saide , Korur Fikret 
Published: May 2014

The aim of this study is to analyze the effects of project‐based learning on students' academic achievement, attitude, and retention of knowledge in relation to the subject of “Electricity in Our Lives” in a fourth‐grade science course. The study was conducted in a quasi‐experimental design as a “pre‐test, post‐test with control group.” In the experimental group, the unit was taught through the project‐based learning method. The measuring tools were administered to both groups before and after the applications. To perfectly analyze the “process” of the method, seven different learning assessment “forms” were administered to the students. The findings of the forms indicated that the students learn to construct their own learning and to evaluate changes in their own behavior through the application of the method.The application of different methods between both groups had a statistically significant effect in terms of academic achievement, (F(1,112) = 46.78, p = .000) and of retention of knowledge (F(1,112) = 35.24, p = .000). However, there were no statistically significant effects from being in different groups for the attitudes of students (F(1,112) = .99, p = .321). For the students, being in the project‐based learning groups resulted in better academic achievement and retention of knowledge than being in the traditional teaching group.
Neither silverfish nor fowl: the enigmatic Carboniferous Carbotriplura kukalovaeKluge, 1996 (Insecta: Carbotriplurida) is the putative fossil sister group of winged insects (Insecta: Pterygota)
Authors: STANICZEK ARNOLD H. , SROKA PAVEL , BECHLY GÜNTER 
Published: May 2014

AbstractWe revise the type material of the enigmatic fossil insect Carbotriplura kukalovae Kluge, 1996 from the Pennsylvanian of the Czech Republic. Multiple errors in the original description are documented and corrected. C. kukalovae is regarded as a possible transitional fossil link between Zygentoma and Pterygota. Carbotriplurida is therefore elevated to ordinal rank and considered as putative fossil sister group of Pterygota. The paranotal theory of the origin of insect wings and the parachute theory of origin of insect flight are briefly discussed and further corroborated. Testajapyx thomasi from the Pennsylvanian of Mazon Creek is tentatively considered as Dermaptera rather than Diplura.
Imprinting in rice: the role of DNA and histone methylation in modulating parent‐of‐origin specific expression and determining transcript start sites
Authors: Du Miru , Luo Ming , Zhang Ruofang , Finnegan E. Jean , Koltunow Anna M. G. 
Published: May 2014

SummaryOver 200 imprinted genes in rice endosperm are known, but the mechanisms modulating their parental allele‐specific expression are poorly understood. Here we use three imprinted genes, OsYUCCA11, yellow2‐like and ubiquitin hydrolase, to show that differential DNA methylation and tri‐methylation of histone H3 lysine 27 (H3K27me3) in the promoter and/or gene body influences allele‐specific expression or the site of transcript initiation. Paternal expression of OsYUCCA11 required DNA methylation in the gene body whereas the gene body of the silenced maternal allele was hypomethylated and marked with H3K27me3. These differential markings mirror those proposed to modulate paternal expression of two Arabidopsis genes, PHERES1 and a YUCCA homolog, indicating conservation of imprinting mechanisms. At yellow2‐like, DNA hypomethylation in the upstream flanking region resulted in maternal transcripts that were longer than paternal transcripts; the maternal transcript initiation site was marked by DNA methylation in the paternal allele, and transcription initiated ~700 bp downstream. The paternal allele of an ubiquitin hydrolase gene exhibited gene body DNA methylation and produced full‐length transcripts, while the maternal allele was hypomethylated in the 5′ gene body and transcripts initiated from a downstream promoter. Inhibition of DNA methylation by 5‐azacytidine or zebularine activated the long transcripts from yellow2‐like and enhanced expression of the short transcripts from the ubiquitin hydrolase in seedlings, indicating that DNA methylation prevents transcript initiation from cryptic promoters. These observations suggest a paradigm whereby maternal genome hypomethylation is associated with the production of distinct transcripts, potentially diversifying the gene products from the two alleles.
Cytologic and immunocytochemical characterization of feline progressive histiocytosis
Authors: Pinto da Cunha Nazaré , Ghisleni Gabriele , Scarampella Fabia , Fabbrini Fabrizio , Sforna Monica , Cornegliani Luisa , Caniatti Mario , Avallone Giancarlo , Moore Peter , Roccabianca Paola 
Published: May 2014

BackgroundFeline Progressive Histiocytosis (FPH) is a cutaneous dendritic cell neoplasm characterized by slow progression and spread to internal organs in the terminal stage.FPHis often misdiagnosed as an inflammatory reaction and has not been fully characterized from a cytologic diagnostic perspective.ObjectivesThe purpose of the study was to characterize the cytologic and immunocytochemical aspects useful forFPHdiagnosis.MethodsFine‐needle aspiration cytologic samples of 5 cases ofFPHconfirmed by skin biopsy and necropsy were evaluated. Immunocytochemistry with antibodies recognizingCD1a,CD1c,CD3,CD11b,CD18,CD21, andMHCIIwas performed on air‐dried, acetone‐fixed smears. E‐cadherin expression was assessed on paraffin‐embedded skin biopsies. Transmission electron microscopy (TEM) was performed in one case.ResultsMain cytologic findings on variably cellular samples were characterized by single to cohesive large, round to polygonal cells with intermediate to low N/C ratio, abundant clear homogeneous cytoplasm, and round to oval nuclei with rare bi‐ to multinucleated atypical cells, associated with low numbers of small lymphocytes and/or neutrophils. Neoplastic cells expressedCD1a,CD1c,CD11b,CD18, andMHCII. Anti‐CD3 antibodies identified reactive T cells admixed with the neoplastic cells. E‐cadherin expression was observed in all but one case.TEMfailed to identify Birbeck granules in one case.ConclusionsFPHis a distinctive neoplastic lesion composed of nonphagocytizing histiocytes variably admixed with neutrophils and small mature lymphocytes. Immunocytochemical analysis withCD1 is mandatory to confirm a dendritic cell origin. Immunocytochemistry and cytomorphology allowed the specific and rapid diagnosis ofFPHon cytologic samples.
Oxidative stress increases in retinas of dogs in acute glaucoma but not in chronic glaucoma
Authors: Chen Thomas , Gionfriddo Juliet R. , Tai Pei‐Yi , Novakowski Anna N. , Alyahya Khaleel , Madl James E. 
Published: May 2014

AbstractObjectiveTo test the hypothesis that oxidative stress occurs early in the pathogenesis of glaucoma in dogs.AnimalsSections from eight control retinas and 25 retinas from dogs with primary glaucoma.MethodsFor retinas embedded in paraffin, sections were immunohistochemically stained for malondialdehyde (MDA) and 3‐nitrotyrosine (NT). For retinas embedded in plastic, serial 0.5‐μm sections were immunogold‐stained for total glutathione, taurine, and glutamate.ResultsIncreased immunostaining forMDAandNT, markers of oxidative stress, occurred in retinal ganglion cells (RGCs) and other neurons in acute glaucoma, but not in chronic glaucoma. In minimally damaged regions, immunostaining for the antioxidant glutathione was decreased inRGCs, neurons of the inner nuclear layer (INL), and Müller cell processes. The loss of glutathione immunostaining inRGCs occurred without a decrease in glutamate immunostaining. Neurons with nuclear damage in theINLhad low levels of glutathione, taurine, and glutamate. In severely damaged regions, immunostaining for glutathione was increased in the remaining retinal tissue.ConclusionsImmunohistochemical staining revealed an increase in markers of oxidative stress and loss of glutathione in neurons with minimal damage during acute glaucoma. Oxidative changes were no longer present in chronic glaucomatous retinas, suggesting transient oxidative stress occurs early in glaucoma. The loss of glutathione in minimally damaged regions occurred without a significant redistribution of glutamate, suggesting oxidative stress may occur before glutamate redistribution. Alteration in markers of oxidative stress occurs early in canine glaucoma, suggesting oxidative stress may contribute to subsequent glutamate redistribution and other damaging processes.
Religious Autonomy and Religious Entrepreneurship: An Evolutionary-Institutionalist’s Take on the Axial Age
Authors: Abrutyn Seth 
Published: May 2014

AbstractThrough the first millenniumbce, religio-cultural revolutions occurred in China, Greece, Israel, and India. Commonly referred to as the Axial Age, this epoch has been identified by some scholars as period of parallel evolution in which many of the World Religions appeared for the first time and humanity was forever changed. Axial scholarship, however, remains in an early stage as many social scientists and historians question the centrality of this era in the human story, while other unsettled debates revolve around what was common across each case. The paper below considers the Axial Age from an evolutionary-institutionalist’s perspective: what was axial was (1) the first successful religio-cultural entrepreneurs in human history and, thereby, (2) the evolution of autonomous religious spheres distinct from kinship and polity. Like the Urban Revolutions that qualitatively transformed human societies 3,000 years prior, the Axial Age represents a reconfiguration of the physical, temporal, social, and symbolic space in irreversible ways.
Comparing Experiences of Academic Mobility and Migration
Authors: Kirpitchenko Liudmila 
Published: May 2014

AbstractAcademic mobility and accompanying migration have become increasingly evident as manifestations of globalization and internationalization of education worldwide. This paper aims to provide some insights into intercultural communication in academia by comparing experiences of students and academics who partake in academic mobility or/and academic migration. It seeks to reflect on how differences in cultural patterns impact on the integrational experiences and outcomes of academic learning and everyday interactions. Two contrasting cultural patterns ofcollectivismandindividualismare explored, as they are displayed in intercultural interactions among migrants and hosting societies. To expose this contrast effectively, this paper focuses on the Russian-speaking mobile academics and compares their intercultural experiences in academia of two countries—Italy and Australia. In-depth interviews were conducted with twenty-two academic migrants or/and mobile academics on their experiences, views and perceptions of intercultural integration in two diverse settings. This paper explores diverse aspects of intercultural dialogue and compares perceptions of intercultural integration and feelings of wellbeing. It analyses evolving empirical manifestations of cosmopolitanism in everyday intercultural interactions and argues that postmodern cosmopolitan milieu facilitates intercultural integration and enables knowledge transfer and creation of shared cultural meanings.
Taking Sides: An Investigation into Reinhold Niebuhr’s Rise to the Position of Public Intellectual
Authors: Smith Graeme 
Published: May 2014

AbstractThis article investigates the reason for Reinhold Niebuhr’s rise to prominence as a public intellectual; it considers first the nature of Niebuhr’s success before then arguing that the rhetorical style of his sermons and lectures, the polemical style of his journalism and his political activism were major factors in his rise. What is suggested in the article is that Niebuhr constructed himself as a political figure and that this was crucial in his rise to prominence.
Towards a Theology of Urban Regeneration: Stories from Devonport
Authors: Nixon David 
Published: May 2014

AbstractThis article seeks to explore a public theology of urban regeneration, developed out of liberation and postmodern theologies, as well as reflections on place and space, and augmented by critical discussions about the involvement of faith communities in urban development. This theology is actualized in the experience of one uk regeneration programme in Devonport, Plymouth via an analysis of local neighbourhood stories, and extended to include a critique of national urban policy. These local voices expand traditional concepts such as death and resurrection, sin and redemption to provide a richer theological understanding of God’s relationship to the human creation; equally, attention to the tradition provides further insights into what is happening at the level of the street. When neighbourhood and global configurations are juxtaposed, they result in an imaginative Devonport Trinity, which allows and heals the binaries and complexities of (post)modern urban communities.
The Consolidation of the Islamic Community in Modern Croatia: A Unique Path to the Acceptance of Islam in a Traditionally Catholic European Country
Authors: Mujadžević Dino 
Published: May 2014

Abstract
Although relations between Catholic Croatia and Islam were burdened historically by more than three centuries of Ottoman/Bosnian-Habsburg/Croatian warfare on Croatian soil, creating an extremely negative image of Muslims in the Croatian culture and collective memory, during most of the 20th century, with exception of early 1990s, attitudes towards Islam and Muslims in Croatian society were surprisingly mostly positive. The legal status of the sole Muslim representative organisation, the Islamic Community in Croatia, was confirmed by special agreement with the state in 2002. The author argues that besides the obvious cultural and linguistic proximity of Bosnian Muslims and Croats, several factors contributed to this positive environment: the remoteness of Ottoman wars in time, a fear of a common political enemy (Serbia), and the Austro-Hungarian tradition of early legal recognition of Islam.
Religious Retreats and Transcultural Challenges: Recreating Senegalese Tijani Islam in Metropolitan France
Authors: Smith Gina Gertrud 
Published: May 2014

Abstract
Every year, in agreement with municipal authorities and without publicity, a Senegalese Haalpulaar Sufi sheikh and his Fulfulde-speaking adherents create a daaka, a religious space, in Mantes-la-Jolie. Some 5000 migrants re-establish the social and religious life of their Tijani culture, vitalising the programme of a retreat of the sacred village of Medina Gounass in Senegal and the chain of sheikhs and their Baraka. The article uses various concepts of memory (Jan Assmann, Astrid Erll and Danièle Hervieu-Léger) in order to place the daaka within a transcultural and French context. This is done on the backdrop of Haalpulaar history.
Use of Radar Chaff for Studying Circulations in and around Shallow Cumulus Clouds
Authors: Jung Eunsil , Albrecht Bruce 
Published: May 2014

AbstractCirculations in and around cumulus clouds are inferred by using a passive tracer (radar chaff) and an airborne cloud radar during the Barbados Aerosol Cloud Experiment (BACEX). The radar chaff elements used for this experiment are fibers that are cut to a length of about ½ of the radar wavelength to maximize radar returns by serving as dipole antennas. The fibers are packed in fiber tubes and are mounted in a dispenser beneath the wing of the aircraft. The chaff was released near the tops and edges of a growing small cumulus cloud. The aircraft then made penetrations of the cloud at lower levels to observe the chaff signals above the aircraft with the zenith-pointing cloud radar. This study shows that the environmental air above the cloud top descends along the downshear side of the cloud edge and is subsequently entrained back into the same cloud near the observation level. The in-cloud flow follows an inverted letter P pattern. The merits and limitations of the chaff method for tracking circulations in and around small cumuli are discussed.
On Geometrical Aspects of Interior Ocean Mixing
Authors: McDougall Trevor J. , Groeskamp Sjoerd , Griffies Stephen M. 
Published: May 2014

Abstract
The small-slope approximation to the full three-dimensional diffusion tensor of epineutral diffusion gives exactly the same tracer flux as the commonly used projected nonorthogonal diffusive flux of layered ocean models and of theoretical studies. The epineutral diffusion achieved by this small-slope approximation is not exactly in the direction of the correct epineutral tracer gradient. That is, the use of the small-slope approximation leads to a very small flux of tracer in a direction in which there is no epineutral gradient of tracer. For (the tracer) temperature or salinity, the difference between the correct epineutral gradient and the small-slope approximation to it is proportional to neutral helicity. The authors also make the point that small-scale turbulent mixing processes act to diffuse tracers isotropically (i.e., the same in each spatial direction) and hence it is strictly a misnomer to call this process “dianeutral diffusion” or “vertical diffusion.” This realization also has implications for the diffusion tensor.