bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photopharmacological modulation of hippocampal local field potential by caged‐glutamate with MicroLED probe
Authors: Okada Shogo , Ohkawa Noriaki , Moriya Kazuki , Saitoh Yoshito , Ishikawa Mikiko , Oya Kakeru , Nishikawa Atsushi , Sekiguchi Hiroto 
Published: August 2024

AbstractAimPhotopharmacology is a new technique for modulating biological phenomena through the photoconversion of substances in a specific target region at precise times. Caged compounds are thought to be compatible with photopharmacology as uncaged ligands are released and function in a light irradiation‐dependent manner. Here, we investigated whether a microscale light‐emitting diode (MicroLED) probe is applicable for the photoconversion of caged‐glutamate (caged‐Glu) in vivo.MethodsA needle‐shaped MicroLED probe was fabricated and inserted into the mouse hippocampal dentate gyrus (DG) with a cannula for drug injection and a recording electrode for measuring the local field potential (LFP). Artificial cerebrospinal fluid (ACSF) or caged‐Glu was infused into the DG and illuminated with light from a MicroLED probe.ResultsIn the caged‐Glu‐injected DG, the LFP changed in the 10–20 Hz frequency ranges after light illumination, whereas there was no change in the ACSF control condition.ConclusionThe MicroLED probe is applicable for photopharmacological experiments to modulate LFP with caged‐Glu in vivo.
Error estimates of exponential wave integrators for the Dirac equation in the massless and nonrelativistic regime
Authors: Ma Ying , Chen Lizhen 
Published: August 2024

AbstractWe present exponential wave integrator Fourier pseudospectral (EWI‐FP) methods and establish their error estimates of the fully discrete schemes for the Dirac equation in the massless and nonrelativistic regime. This regime involves a small dimensionless parameter where , and is inversely proportional to the speed of light. The solution exhibits highly oscillatory behavior in time and rapid wave propagation in space in this regime. Specifically, the time oscillations have a wavelength of , while the spatial oscillations have a wavelength of , with a wave speed of . We employ (symmetric) exponential wave integrators for temporal derivatives and Fourier spectral discretization for spatial derivatives. We rigorously derive the error bounds which explicitly depend on the mesh size , the time step and the small dimensionless parameter . The error estimates for the EWI‐FP methods demonstrate that their meshing strategy requirement (‐scalability) necessitates setting and when . Finally, some numerical examples are provided to validate the error bounds.
Model predictive control with thermal constraints for fuel cell hybrid electric vehicle based on speed prediction
Authors: Fu Jiangtao , Fan Bo , Fu Zhumu , Song Shuzhong 
Published: August 2024

AbstractBecause of the soft dynamic performance of the fuel cell stack, the battery is usually integrated in the power system in fuel cell hybrid electric vehicles. In this article, a real time energy management strategy considering thermal constraints based on speed prediction with neuron network is proposed. The main principle of the proposed control strategy is to get the future power requirement with model predictive control based on the historic speed information, then optimize the objective, function according to the state variables. The objective function is set to minimize the equivalent fuel consumption of the vehicle and extend the life span of the fuel cell stack based on thermal constraints. Contrasting with the control strategy without thermal constraints under the World Light Vehicle Test Cycle driving cycle, the proposed energy management is 0.9% higher, but the temperature of the fuel cell stack and the battery can be limited within an appropriate range. The total equivalent fuel consumption is 3.9% lower than dynamic programming control strategy, which proves the availability of the proposed control strategy can reduce the equivalent fuel consumption while prolonging the fuel cell stack life span. Hardware in loop (HIL) experiment is implemented to testify the real time application of the proposed control strategy.
A Systematic Review and Meta‐Analysis of Management Options for Empty Nose Syndrome: A Proposed Management Algorithm
Authors: Hussain Salman , Hayat Jafar , Almhanedi Hamad , Alherz Mohammad , Ebrahim Mahmoud , Lari Ali , Thamboo Andrew 
Published: August 2024

AbstractObjectiveEmpty nose syndrome (ENS) is an acquired condition characterized by paradoxical nasal obstruction and sensation of nasal dryness often accompanied by psychological disorders such as depression or anxiety, typically occurring after the loss of inferior turbinate tissue or volume in the setting of prior sinonasal surgery. This review aims to identify and evaluate the reported management options.Data SourcesPubMed, Scopus, and Web of Science.Review MethodsThe terms “empty nose syndrome” OR “atrophic rhinitis” were used in a systematic search of original articles since the year 1990, yielding 1432 individual studies. These were screened on the Covidence platform for inclusion if any intervention was reported for the treatment of ENS. A pooled analysis of standardized mean differences (SMDs) combined with a random effects model was employed to report outcomes in Empty Nose 6‐Item Questionnaire (ENS6Q), Sino‐Nasal Outcome Test (SNOT), anxiety, and depression scores.ResultsA total of 35 articles were included, comprising 957 individual ENS patients. Surgical interventions mostly in the form of meatus augmentation implants accounted for 26 out of the 36 articles. The remaining ten articles included medical and psychological management options. SMD in SNOT, ENS6Q, anxiety, and depression scores were reported and demonstrated statistically significant improvements in follow‐up periods of up to 1 year. All articles reported favorable outcomes following their chosen interventions.ConclusionThere is a paucity of evidence on the management of ENS and an absence of randomized controlled trials. Surgical intervention appears to be the current mainstay of treatment, but there is a potential role for psychological and medical management.
Virtually Augmented Surgical Navigation in Endoscopic Sinus Surgery Simulation Training: A Prospective Trial of Repeated Measures
Authors: Latour Mackenzie , Alvarez Ivan , Knackstedt Mark , Yim Michael 
Published: August 2024

AbstractObjectiveThe objective of this study was to explore the educational utility of virtually augmented surgical navigation (VASN) in simulation training for endoscopic sinus surgery.Study DesignProspective trial using within‐subjects design.SettingSingle academic institution.MethodsOtolaryngology trainees (n = 15) were enrolled in a prospective trial of repeated measures. Participants performed unilateral functional endoscopic sinus surgery (FESS) on a 3‐dimensional‐printed sinus model without instruction. Participants then underwent educational intervention incorporating VASN tools—featuring anatomic overlay delineations, virtual planning points, proximity alerts, digital measurements, as well as artificial intelligence‐generated endoscopic viewpoints. With the VASN tools activated, participants then performed FESS on the contralateral side of the model. Primary outcomes of interest included number of major complications, time to complete anterior fess, steps completed, and technical skills score. Descriptive statistics were performed to describe participant characteristics and bivariate analysis were used to evaluate differences in subjective and objective outcome measures.ResultsA majority (93%) of residents strongly agreed that simulation intervention improved their confidence in surgical skills related to FESS. Complications decreased from 13 instances to 3 following interventions. Initial technical skills score of 45.2 increased to 54.4 postintervention (P < .0001) and global score also improved by 4.6 points on average (P < .001). Time to anterior FESS decreased from 1356 to 915 seconds (P = .006) and average number of completed surgical steps increased from 3.3 to 4.6 (P < .001).ConclusionThis simulation study contributes to growing evidence supporting utility of advanced technology in surgical education. Results suggest that VASN serves as a beneficial adjunct in FESS simulation training.
Changes in glomerular filtration rate in patients with body mass index ≥35 kg/m2 treated with metabolic and bariatric surgery versus GLP‐1 agonist at 1‐year follow‐up
Authors: Henao‐Carrillo Diana Cristina , Jurado‐Florez Mayra Alejandra , Muñoz Óscar Mauricio 
Published: August 2024

AbstractBackgroundMetabolic and bariatric surgery (MBS) reduces glomerular hyperfiltration. The renoprotective effects of GLP‐1 analogs were derived from clinical studies in type 2 diabetes (T2D). The objective of this study was to evaluate the changes in glomerular filtration rate (GFR) over time associated with weight loss in patients with a BMI ≥ 35 kg/m2 treated with liraglutide compared with patients treated with MBS.MethodsA longitudinal study derived from a retrospective cohort of patients with BMI ≥ 35 kg/m2 treated with either MBS or liraglutide 3 mg/day, with follow‐up ≥1 year. Clinical variables, baseline GFR, and 1‐year GFR were analyzed. A generalized estimating equation (GEE) model was used to compare changes in GFR between both groups while controlling for confounding variables.ResultsA total of 159 patients were included in the analysis. Of these, 129 patients underwent MBS (median age 60.5 years [IQR 51.8–66.6], body mass index (BMI) 40.9 kg/m2 [IQR 0.68–0.89]), and 30 patients were treated with liraglutide (median age 56 years [IQR 46–62], BMI 37.4 kg/m2 [IQR 0.69–0.93]). No difference in baseline GFR or at 12 months of follow‐up was found between the two interventions. GEE analysis revealed an increase of 0.32 mL/min/1.73 m2 per month of follow‐up. Factors associated with a greater increase in GFR were the percentage total weight loss (%TWL) (0.12 mL/min/1.73 m2, p = 0.023) and baseline GFR (0.69 mL/min/1.73 m2, p > 0.001) for both interventions, independent of a history of T2D.ConclusionIn patients with BMI ≥ 35 kg/m2, changes in GFR are related to %TWL and baseline GFR, regardless of the presence of diabetes or the type of intervention used.
Evaluation of socioecological factors on health behaviors and weight change during major life event: A cross‐sectional study using data collected during the COVID‐19 pandemic
Authors: Chui Tsz Kiu , Cedillo Yenni E. , El Zein Assil , Pavela Gregory , Caldwell Ann E. , Peters John C. , Friedman James E. , DebRoy Swati , Oslund Jennifer L. , Das Sai Krupa , Roberts Susan B. , Hill James O. , Sayer R. Drew 
Published: August 2024

AbstractBackgroundSocioecological factors are associated with key health behaviors that are critical for weight management, and major life events may disrupt engagement in these behaviors. However, the influence of socioecological factors on health behaviors in the midst of major life events is not clear and is difficult to study due to the random and sporadic nature of their occurrence. The COVID‐19 pandemic provided a unique opportunity to study a major life event and its impacts on diet, physical activity, and body weight.ObjectiveThis cross‐sectional study aimed to investigate associations between socioecological factors (environmental, interpersonal, and individual) and self‐reported weight change during a major life event using data collected during the COVID‐19 pandemic, and whether the associations were mediated through self‐reported changes in eating and physical activity behaviors.MethodsParticipants self‐reported socioecological factors, weight change, and changes in eating behaviors (EB) and physical activity (PA) via online questionnaires between December 2020 and October 2021. Changes in EB and PA were measured using scales with higher scores reflecting more positive changes during the COVID‐19 pandemic.ResultsParticipants (n = 1283) were mostly female (84.9%) with age 52.1 ± 14.1 years (mean ± SD) and BMI of 32.9 ± 8.2 kg/m2. Stronger healthy eater and exercise identities (individual factors) were associated with higher EB scores (EBS) and PA scores (PAS), respectively (p's < 0.00001). Less discouragement for healthy eating by family/friends (interpersonal factor) was associated with higher EBS (p = 0.002). Higher EBS and PAS were associated with weight loss. The indirect effect of healthy eater identity (−0.72; 95% CI: −0.90, −0.55) and discouragement for diet (0.07; 95% CI: 0.03, 0.12) on weight change through EBS were significant, as was the indirect effect of exercise identity (−0.25; 95% CI: −0.35, −0.15) on weight change through PAS.ConclusionsStronger identities and less discouragement from family/friends may support health promoting behaviors and weight loss during a major life event, as well as identify additional behavioral targets for lifestyle interventions.Clinical Trial RegistrationIWCR was registered at ClinicalTrials.gov (NCT04907396).
Experiences of families post treatment for childhood brain tumours during medical clinic consultations regarding health‐related quality of life, unmet needs and communication barriers: A qualitative exploration
Authors: Bull Kim S. , Stubley Shelly , Freeman Anita , Liossi Christina , Darlington Anne‐Sophie E. , Grootenhuis Martha A. , Hargrave Darren , Morris Christopher , Walker David A. , Kennedy Colin R. 
Published: August 2024

AbstractBackgroundMany studies highlight poor health‐related quality of life (HRQoL) in children treated for brain tumours and their parents. However, little is known about the extent to which their informational, healthcare and communication needs regarding HRQoL are met during medical outpatient consultations.AimTo explore the experiences of families regarding communication with physicians about HRQoL issues during consultations after treatment for childhood brain tumours.MethodsInterviews were conducted with 18 families of children and adolescents aged 8–17 years after completion of brain tumour treatment. Participants had completed treatment within the last 5 years and were receiving regular outpatient follow‐up care. Thematic analysis was undertaken using the Framework Method.ResultsFive main themes were identified: (i) unmet emotional and mental health needs; (ii) double protection; (iii) unmet information needs; (iv) communication barriers within consultations; and (v) finding a new normal.ConclusionThere was a need to improve communication between clinicians and these families, improve information provision, and overcome barriers to conversing with children within these outpatient consultations. Children and their parents should be supported to voice their current needs and concerns regarding their HRQoL. These findings will inform further development of the UK version of the ‘KLIK’ patient‐ and parent‐reported outcome (PROM) portal.
Successful treatment of young childhood standard‐risk hepatoblastoma with cisplatin monotherapy using a central review system
Authors: Saeki Isamu , Ida Kohmei , Kurihara Sho , Watanabe Kenichiro , Mori Makiko , Hishiki Tomoro , Yokoi Akiko , Fujimura Junya , Honda Shohei , Nogami Yuki , Iehara Tomoko , Kazama Takuro , Sekiguchi Masahiro , Kitagawa Norihiko , Matsumura Risa , Nomura Motonari , Yamada Yohei , Hanaki Ryo , Kaneda Hide , Takama Yuichi , Inoue Takeshi , Tanaka Yukichi , Miyazaki Osamu , Nagase Hiroki , Takimoto Tetsuya , Yoshimura Kenichi , Hiyama Eiso 
Published: August 2024

AbstractBackgroundThe JPLT3‐S (Japanese Study Group for Pediatric Liver Tumors‐3) study, conducted cisplatin (CDDP) monotherapy for young children (<3 years old) with standard‐risk hepatoblastoma (HB) using a central review system in Japan. In the previous JPLT2 study, cases with resectable tumors without any annotation factors in the PRETEXT (PRETreatment EXTent of disease) classification (standard‐risk HB) showed favorable outcomes with treatment consisting of CDDP and pirarubicin, but showed toxicities and late complications. In the JPLT3‐S trial, a less intense regimen consisting of CDDP alone was evaluated.MethodsPatients who were less than 3 years of age and with PRETEXT I, II, or III HB without any annotation factors (e.g., E1, E1a, E2, E2a, H1, N1, P2, P2a, V3, and V3a) were eligible for inclusion in this study. In this trial, the central radiological and pathological features of all patients were reviewed. The primary outcome was the 3‐year progression‐free survival (PFS).ResultsA total of 38 patients (23 female) were included. The median patient age was 12 months (range: 2–34). Two patients discontinued treatment because of progressive disease, and five patients discontinued treatment for other reasons. The 3‐year PFS rate was 93.9% (95% confidence interval [CI]: 86.4%–100%). All 38 patients survived (follow‐up period 38–98 months), and the OS rate was 100% (CI: 100). Eighteen of the 38 patients (47.4%) experienced ototoxicity as a late complication.ConclusionCDDP monotherapy regimen is feasible in young patients with localized HB, as classified by a central review.
Registration of provitamin A‐enriched tropical maize inbred lines
Authors: Menkir Abebe , Meseka Silvestro , Gedil Melaku , Ojo Tayo , Mengesha Wende 
Published: August 2024

AbstractVitamin A deficiency and its associated disorders are pervasive in sub‐Saharan Africa (SSA) including many middle‐ and low‐income countries across the world. Provitamin A‐enriched maize (Zea mays L.) inbred lines with desirable agronomic and adaptive traits have been developed and used to generate and commercialize maize varieties with medium to high levels of provitamin A in a few countries to curb vitamin A deficiency. Nonetheless, these inbred lines have not been made widely available to the public and private sector breeders in many countries. The main purpose for releasing the 21 provitamin A‐enriched tropical maize inbred lines (PI 705424–PI 705444, Reg. nos. GP‐624–GP‐644) is to supply maize breeders with elite source germplasm for increasing provitamin A and other carotenoids to much higher levels to offset losses during storage, natural degradation, and processing. These inbred lines were developed at the International Institute of Tropical Agriculture (IITA) from backcrosses of high β‐carotene temperate lines as donors and elite tropical lines as recipients. These inbred lines were developed through repeated self‐pollination with rigorous visual selection among and within lines for plant vigor, synchronous silk emergence and pollen shedding, low ear placement, and resistance to lodging and major tropical diseases, followed by selection for bright yellow to orange kernel color with semi flint to flint kernel texture after harvest. The released maize inbred lines will be diverse sources of favorable alleles to accelerate genetic gain in provitamin A and other beneficial carotenoid enrichment for human health.
Correlation of dopant solution on doping mechanism and performance of F4TCNQ‐doped P3HT
Authors: He Jiaxin , Shan Hongtao , Zhu Bingyan , Cao Xueting , Zhou Jianjun , Huo Hong 
Published: August 2024

AbstractUnderstanding the doping mechanism between the dopants and the conjugated polymers (CPs) is crucial for efficiently utilizing the doping process in a controllable manner. In this work, we doped the poly(3‐hexylthiophene) (P3HT) films with 2,3,5,6‐tetrafluoro‐7,7,8,8‐tetracyanoquinodimethane (F4TCNQ) from a chlorobenzene/acetonitrile (CB/AN) solvent blend and pure AN solvent by using the common sequential doping method. We found that the dissolution ability of the dopant solvent to P3HT and the concentration of the dopant solution were two critical factors to determine the doping process (solution doping or sequential doping) and the doping region (the amorphous or the crystalline phase). When the concentration of the dopant solution was low, solution doping was dominant in the P3HT film doped with F4TCNQ CB/AN solution, and the amorphous regions were doped in the P3HT film doped with F4TCNQ AN solution. With the increase of the dopant solution concentration, the ratio of ordered integer charge transfer (ICT) species, which formed from sequentially doped crystalline domains in the P3HT precast film, increased. Based on the above doping mechanism, a P3HT film with good electrical and tensile performance could be constructed by doping from F4TCNQ CB/AN solution with a relatively low concentration. Our work indicates that the dissolution or swelling ability of the dopant solvent to CP is an important factor in determining not only the doping mechanism but also the electrical and mechanical performances of doped CP films.
Bayesian inference for two populations of Lomax distribution under joint progressive Type‐II censoring schemes with engineering applications
Authors: Hasaballah Mustafa M. , Tashkandy Yusra A. , Balogun Oluwafemi Samson , Bakr Mahmoud E. 
Published: August 2024

AbstractThe joint progressive Type‐II censoring scheme is an advantageous cost‐saving strategy. In this paper, investigated classical and Bayesian methodologies for estimating the combined parameters of two distinct Lomax distributions employing the joint progressive Type‐II censoring scheme. Maximum likelihood estimators have been derived, and asymptotic confidence intervals are presented. Bayesian estimates and their corresponding credible intervals are calculated, incorporating both symmetry and asymmetry loss functions through the utilization of the Markov Chain Monte Carlo (MCMC) method. The simulation aspect has employed the MCMC approximation method. Furthermore, discussed the practical application of these methods, providing illustration through the analysis of a real dataset.
Novel CYLD Pathogenic Variant Associated with Multiple Cylindromas of the Scalp—A Case Report
Authors: Amaral Inês P. , Soares Ivânia , Correia Madalena P. , Correia Catarina , Vasconcelos Pedro , Almeida Luis S. , Filipe Paulo 
Published: August 2024

Abstract
Cylindromas are rare, benign adnexal neoplasms primarily found on the scalp and face, with a higher incidence in women and typically manifesting in the second or third decade of life. These tumours can present as single or multiple nodules, with the latter form often linked to CYLD gene mutations, particularly in the context of CYLD cutaneous syndrome. Here, we report a case of a 61-year-old male presenting with multiple cylindromas of the scalp, prompting genetic testing that revealed a novel pathogenic variant in the CYLD gene.
Predictive roles of cognitive biases in health anxiety: A machine learning approach
Authors: Shi Congrong , Du Xiayu , Chen Wenke , Ren Zhihong 
Published: August 2024

AbstractPrior work suggests that cognitive biases may contribute to health anxiety. Yet there is little research investigating how biased attention, interpretation, and memory for health threats are collectively associated with health anxiety, as well as the relative importance of these cognitive processes in predicting health anxiety. This study aimed to build a prediction model for health anxiety with multiple cognitive biases as potential predictors and to identify the biased cognitive processes that best predict individual differences in health anxiety. A machine learning algorithm (elastic net) was performed to recognise the predictors of health anxiety, using various tasks of attention, interpretation, and memory measured across behavioural, self‐reported, and computational modelling approaches. Participants were 196 university students with a range of health anxiety severity from mild to severe. The results showed that only the interpretation bias for illness and the attention bias towards symptoms significantly contributed to the prediction model of health anxiety, with both biases having positive weights and the former being the most important predictor. These findings underscore the central role of illness‐related interpretation bias and suggest that combined cognitive bias modification may be a promising method for alleviating health anxiety.