bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensing spatial and temporal coordination in teams using the smartphone
Authors: Feese Sebastian , Burscher Michael Joseph , Jonas Klaus , Tröster Gerhard 
Published: September 2014

AbstractTeams are at the heart of today’s organizations and their performance is crucial for organizational success. It is therefore important to understand and monitor team processes. Traditional approaches employ questionnaires, which have low temporal resolution or manual behavior observation, which is labor intensive and thus costly. In this work, we propose to apply mobile behavior sensing to capture team coordination processes in an automatic manner, thereby enabling cost-effective and real-time monitoring of teams. In particular, we use the built-in sensors of smartphones to sense interpersonal body movement alignment and to detect moving sub-groups. We aggregate the data on team level in form of networks that capture a) how long team members are together in a sub-group and b) how synchronized team members move. Density and centralization metrics extract team coordination indicators from the team networks. We demonstrate the validity of our approach in firefighting teams performing a realistic training scenario and investigate the link between the coordination indicators and team performance as well as experienced team coordination. Our method enables researchers and practitioners alike to capture temporal and spatial team coordination automatically and objectively in real-time.
RANTES/CCL5 mediated-biological effects depend on the syndecan-4/PKCα signaling pathway
Authors: Maillard Loïc , Saito Naoaki , Hlawaty Hanna , Friand Véronique , Suffee Nadine , Chmilewsky Fanny , Haddad Oualid , Laguillier Christelle , Guyot Erwan , Ueyama Takehiko , Oudar Olivier , Sutton Angela , Charnaux Nathalie 
Published: September 2014

ABSTRACT
The perpetuation of angiogenesis is involved in certain chronic inflammatory diseases. The accelerated neovascularisation may result from an inflammatory status with a response of both endothelial cells and monocytes to inflammatory mediators such as chemokines. We have previously described in vitro and in vivo the pro-angiogenic effects of the chemokine Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES)/CCL5. The effects of RANTES/CCL5 may be related to its binding to G protein-coupled receptors and to proteoglycans such as syndecan-1 and -4. The aim of this study was to evaluate the functionality of syndecan-4 as a co-receptor of RANTES/CCL5 by the use of mutated syndecan-4 constructs. Our data demonstrate that site-directed mutations in syndecan-4 modify RANTES/CCL5 biological activities in endothelial cells. The SDC4S179A mutant, associated with an induced protein kinase C (PKC)α activation, leads to higher RANTES/CCL5 pro-angiogenic effects, whereas the SDC4L188QQ and the SDC4A198del mutants, leading to lower phosphatidylinositol 4,5-bisphosphate (PIP2) binding or to lower PDZ protein binding respectively, are associated with reduced RANTES/CCL5 cellular effects. Moreover, our data highlight that the intracellular domain of SDC-4 is involved in RANTES/CCL5-induced activation of the PKCα signaling pathway and biological effect. As RANTES/CCL5 is involved in various physiopathological processes, the development of a new therapeutic strategy may be reliant on the mechanism by which RANTES/CCL5 exerts its biological activities, for example by targeting the binding of the chemokine to its proteoglycan receptor.
Immediate and punitive impact of mechanosensory disturbance on olfactory behaviour of larval Drosophila
Authors: Saumweber Timo , Cano Carmen , Klessen Juliane , Eichler Katharina , Fendt Markus , Gerber Bertram 
Published: September 2014

ABSTRACT
The ability to respond to and to learn about mechanosensory disturbance is widespread among animals. Using Drosophila larvae, we describe how the frequency of mechanosensory disturbance (‘buzz’) affects three aspects of behaviour: free locomotion, innate olfactory preference, and potency as a punishment. We report that (i) during 2–3 seconds after buzz onset the larvae slowed down and then turned, arguably to escape this situation; this was seen for buzz frequencies of 10, 100, and 1000 Hz, (ii) innate olfactory preference was reduced when tested in the presence of the buzz; this effect was strongest for the 100 Hz frequency, (iii) after odour-buzz associative training, we observed escape from the buzz-associated odour; this effect was apparent for 10 and 100, but not for 1000 Hz. We discuss the multiple behavioural effects of mechanosensation and stress that the immediate effects on locomotion and the impact as punishment differ in their frequency-dependence. Similar dissociations between immediate, reflexive behavioural effects and reinforcement potency were previously reported for sweet, salty and bitter tastants. It should be interesting to see how these features map onto the organization of sensory, ascending pathways.
Spatial pattern of cell geometry and cell-division orientation in zebrafish lens epithelium
Authors: Mochizuki Toshiaki , Suzuki Shohei , Masai Ichiro 
Published: September 2014

ABSTRACT
Cell proliferation is a key regulator of tissue morphogenesis. We examined cell proliferation and cell division in zebrafish lens epithelium by visualizing cell-cycle phases and nuclear positions, using fluorescent-labeled geminin and histone proteins. Proliferation was low in the anterior region of lens epithelium and higher in the marginal zone anterior to the equator, suggesting that the proliferation zone, called the germinative zone, is formed in zebrafish lens. Interestingly, cell-division orientation was biased longitudinally in the anterior region, shifted from longitudinal to circumferential along the anterior–posterior axis of lens sphere, and was biased circumferentially in the peripheral region. These data suggest that cell-division orientation is spatially regulated in zebrafish lens epithelium. The Hertwig rule indicates that cells tend to divide along their long axes. Orientation of long axes and cell division were biased similarly in zebrafish lens epithelium, suggesting that cell geometry correlates with cell-division orientation. A cell adhesion molecule, E-cadherin, is expressed in lens epithelium. In a zebrafish e-cadherin mutant, the long axes and cell-division orientation were shifted more longitudinally. These data suggest that E-cadherin is required for the spatial pattern of cell geometry and cell-division orientation in zebrafish lens epithelium.
The high molecular weight neurofilament subunit plays an essential role in axonal outgrowth and stabilization
Authors: Lee Sangmook , Shea Thomas B. 
Published: September 2014

ABSTRACT
Neurofilaments (NFs) are thought to provide structural support to mature axons via crosslinking of cytoskeletal elements mediated by the C-terminal region of the high molecular weight NF subunit (NF-H). Herein, we inhibited NF-H expression in differentiating mouse NB2a/d1 cells with shRNA directed against murine NF-H without affecting other NF subunits, microtubules or actin. shRNA-mediated NF-H knockdown not only in compromised of late-stage axonal neurite stabilization but also compromised early stages of axonal neurite elongation. Expression of exogenous rat NF-H was able to compensate for knockdown of endogenous NF-H and restored the development and stabilization of axonal neurites. This rescue was prevented by simultaneous treatment with shRNA that inhibited both rat and murine NF-H, or by expression of exogenous rat NF-H lacking the C-terminal sidearm during knockdown of endogenous NF-H. Demonstration of a role for NF-H in the early stages of axonal elaboration suggests that axonal stabilization is not delayed until synaptogenesis, but rather that the developing axon undergoes sequential NF-H-mediated stabilization along its length in a proximal–distal manner, which supports continued pathfinding in distal, unstabilized regions.
A Prospective Study of Shortened Vitamin Supplementation Prior to Cisplatin–Pemetrexed Therapy for Non-Small Cell Lung Cancer
Authors: Takagi Yusuke , Hosomi Yukio , Sunami Kuniko , Nakahara Yoshiro , Okuma Yusuke , Yomota Makiko , Shimokawa Tsuneo , Nagamata Makoto , Iguchi Mari , Okamoto Hiroaki , Okamura Tatsuru , Shibuya Masahiko 
Published: September 2014

Abstract

Background.
Prior supplementation with folic acid and vitamin B12 is required to reduce pemetrexed therapy toxicity; the recommended lead-in time is at least 7 days. On the basis of previous pharmacokinetic and clinical studies, we hypothesized that the lead-in time could be shortened to 24 hours, enabling earlier commencement of standard chemotherapy; thus, we planned the first prospective trial of this regimen.

Methods.
Patients with advanced nonsquamous non-small cell lung cancer who had not previously received cytotoxic chemotherapy were enrolled. After measurement of homocysteine concentrations, the patients received 1,000 μg of vitamin B12 by intramuscular injection and began taking 350–500 μg of oral folic acid daily. Starting 24–48 hours after the vitamin B12 injection, the patients received intravenous 500 mg/m2 pemetrexed and 75 mg/m2 cisplatin for 4 cycles at 3 weekly intervals. The primary endpoint was the proportion of patients who developed neutropenia grade ≥3.

Results.
Thirty patients received chemotherapy starting within 48 hours of the vitamin B12 injection. No treatment-related deaths or grade 4 toxicity occurred. Neutropenia grade ≥3, other laboratory toxicities grade ≥3, and nonlaboratory toxicities grade ≥3 occurred in 6.7%, 13%, and 13% of patients, respectively. The baseline homocysteine concentrations were not higher in patients with grade ≥3 toxicities than in the remainder of the cohort (mean values, 8.6 and 10.7 μmol/L, respectively). The response rate to chemotherapy was 43%.

Conclusion.
The shortened vitamin supplementation was well tolerated and retained antitumor efficacy. Analysis of baseline homocysteine concentrations confirmed the efficacy of short-term vitamin supplementation.
An Overview of Glaciers Distribution in the Nepal Himalaya
Authors: P.C Shakti , Pradhananga Dhiraj , Ma Wenchao , Wang Pei 
Published: September 2014

Correction: On 7th September 2015, Pei Wang was included as an author on this paper. He was omitted from the paper by mistake. John W. Pomeroy was removed as an author of the paper but was included in the Acknowledgements of the paper (p.26)Abstract:Glaciers in the Himalayas are the important resource for fresh water. Continuous releases of the water from these glaciers make an important contribution to the drinking water, agriculture, and hydropower supply of densely populated regions in south and central Asia. Glaciers are not only a necessity for the survival of the people living in the low lying areas but also for their prosperity. Therefore, special attention should be given to detail research in the distribution of the glaciers in the Himalayan region and its surroundings. Physical parameters of glaciers area, length, depth, elevation profiles were analyzed based on the data provided by WGMS and NSIDC (1989), which was updated in 2012. Machhapuchhre, Thyangbo, Cho Oyu, Taweche, Setta, Tingbo and Kanchanjanga glaciers were found as the smallest glaciers in terms of area (<1km2), mean length (< 2km) and mean depth (40m) in the Nepal Himalaya. Langtang Ngojumba, Barun and Yalung glaciers were found as the largest glaciers in terms of area (>50km2). Large difference between start and end elevation point of glaciers of Khumbu, Ngojumba, Imja, Langtang indicates coverage area profiles are large and located in steep slopes of the Nepal Himalaya, which may result in linear erosions and avalanches. This paper also discusses about the Glacier Lake Outburst Flood (GLOF) in the Himalayan region.HYDRO NEPAL Journal of Water, Energy and EnvironmentIssue No. 13, July 2013Page:20-27 Uploaded date: 3/12/2014
Marker Assisted Selection for Bacterial Leaf Blight Resistance in Segregating Populations of Cottondora Sannalu
Authors: Magar Manu Maya , Rani Ch.V. Durga , Auradha G 
Published: September 2014

The present investigation was undertaken with the objective to develop high yielding, fine grain rice varieties possessing broad spectrum durable resistance by transferring bacterial leaf blight (BLB) resistant genes viz., xa13 and Xa21 from B95-1. A popular high yielding and fine grain rice variety, MTU1010 (Cottondora Sannalu), susceptible to BLB and B95-1 carrying resistant genes for BLB (xa13 & Xa21 genes) was selected as the parent for crossing. B95-1 was verified for the presence of target genes by using gene linked primers viz., xa13 promotor and pTA 248. These primers were also used to study polymorphism between resistant (B95-1) and susceptible (MTU1010) parents. The cross viz., MTU1010 x B95-1 was affected during Rabi, 2010 and F1 progenies were confirmed during Kharif, 2011. The F1 plants confirmed as true hybrids for both the genes were advanced to F2 generation and foreground selection was done using gene linked markers. Genetic analysis in F2 populations confirmed that the genes (xa13 & Xa21) governing BLB resistance followed Mendelian inheritance. The phenotypic data analysis revealed that the plants carrying two resistance gene combinations (xa13xa13 Xa21Xa21, xa13xa13Xa21xa21) showed BLB resistance (0-2 scale), while the gene combinations viz., Xa13Xa13Xa21Xa21, Xa13Xa13Xa21xa21, and Xa13xa13Xa21Xa21, Xa13xa13Xa21xa21 showed BLB resistance (0.5-3.0).DOI: http://dx.doi.org/10.3126/ijasbt.v2i3.10570 Int J Appl Sci Biotechnol, Vol. 2(3): 229-237
Distribution and Seasonal Abundance of Potato Tuber Moth: Phthorimaea operculella (Zeller) (Lepidoptera: Gelechiidae) in Nepal
Authors: Giri Y.P. , Thapa R.B. , Dangi N. , Aryal S. , Shrestha S. M. , Pradhan S. B. , Sporleder M. 
Published: September 2014

Annual monitoring of potato tuber moth (PTM) was made in 2008/09 in15 districts of Nepal to understand the distribution and seasonal abundance. The locally made pheromone trap was installed and observed in 24 hours intervals. The activity of PTM was observed in plain, mid hills (below 2200 masl) and high hill districts. The population of PTM was found more in mid-hills than in plain whereas PTM was absent in high hill districts. The highest average number of PTM was observed in May (480±238 moth/month) with no adult moths in October to December in plain whereas 522±174 moth/month was observed in July and 18±4 moth/month in December in mid-hills of Nepal. The seasonal abundance of PTM observed from March to July (74±63 to 126±100 moth/month) in Plain and March to October (191±157 to 104±60 moth/month) in mid-hills. The understanding of PTM population dynamics could be useful to make suitable management decision. DOI: http://dx.doi.org/10.3126/ijasbt.v2i3.10794 Int J Appl Sci Biotechnol, Vol. 2(3): 270-274
Genetic Diversity Assessment of Acid Lime (Citrus Aurantifolia Swingle) Landraces of Eastern Nepal Using RAPD Markers
Authors: Munankarmi NN , Shrestha RL , Rana N , Shrestha JKC , Shrestha S , Koirala R , Shrestha S 
Published: September 2014

Acid lime (Citrus aurantifolia Swingle) is an important commercial fruit crop, cultivated from terai to high hill landscapes of Nepal. However, production and productivity is very low due to various reasons including infestations by various diseases and pests, lack of diseases and pests resistant and high yielding varieties. In this context, determination of genetic variation at molecular level is fundamental to citrus breeders for the development of elite cultivars with desirable traits. In the present study, Random Amplified Polymorphic DNA (RAPD) marker technique has been employed to assess genetic diversity in 60 acid lime landraces representing different agro-ecological zones of eastern Nepal. Nine selected arbitrary primers generated 79 RAPD fragments of which 75 were polymorphic (94.94%). Phenogram was constructed by NTSYSPC ver. 2.21i using UPGMA cluster analysis based on Jaccard’s similarity coefficient to deduce overall genetic diversity and relationships of the acidlime genotypes under study. Sixty acid lime landraces formed seven clusters and similarity value ranged from 38% to 98% with an average of 72%. Genetic variation at different agro-ecological zones was assessed using Popgene ver. 1.32 and found 47% to 69.6% polymorphism. Shannon’s index and Nei’s gene diversity showed highest level of acid lime diversity in Terai zone (PPB, 69.62%; H, 0.213; I, 0.325) followed by mid-hill zone (PPB, 67.09%; H, 0.208; I, 0.317). The results obtained will be useful to citrus breeders for elite cultivar development. The RAPD-PCR technique is found to be the rapid and effective tool for genetic diversity assessment in acid lime landraces of Nepal. DOI: http://dx.doi.org/10.3126/ijasbt.v2i3.10950 Int J Appl Sci Biotechnol, Vol. 2(3): 315-327
Use of Computational Matrix Adjustment to Evaluate the Effectiveness of Common Influenza Vaccines against the Emergence of Drift Variants
Authors: Tram Jennifer 
Published: September 2014

Every year the FDA issues a recommendation for the composition of the year’s common influenza vaccine for influenzas A and B. The FDA can consistently predict the dominance of a particular strand of influenza virus by taking into account previous years’ antigenic characterization percentages. However, the sudden disappearance of dominant antigens and the sudden emergence of drift variants can disrupt this pattern, which questions the effectiveness of that year’s vaccine. Basic Local Alignment Search Tool was used to compare the protein sequences for hemagglutinin and neuraminidase between the strands in the vaccine and the dominant viral strands. This study examined the effectiveness of vaccines from 2000 to 2012, focusing on the transitions between the B/Yamagata and B/Victoria lineages and A/New Caledonia and A/California lineages (H1N1). Between the years 2005 and 2006, dominance of the B/Yamagata lineage, represented by B/Shanghai/361/2002, disappeared almost entirely. For the 2005-2006 flu season, the CDC recommended a B/Shanghai/361/2002 vaccine which expressed a 98% identity to the dominant influenza B hemagglutinin sequence and a 97% identity to the dominant neuraminidase sequence. From 2007 to 2008, the A/New Caledonia virus declined to 34% of cases while the A/Solomon Islands/3/2006 virus increased to 66%. The A/New Caledonia/20/99 vaccine effectively expressed a 97% identity to the hemagglutinin sequence of A/Solomon Islands/3/2006 strand and a 98% identity to the neuraminidase sequence. This study demonstrates that from 2000 to 2012, despite drift variants in influenza viruses, the CDC-recommended vaccine effectively matches the hemagglutinin and neuraminidase protein sequences of the dominant viruses.DOI: http://dx.doi.org/10.3126/ijasbt.v2i3.10952 Int J Appl Sci Biotechnol, Vol. 2(3): 224-228
Injonction « ne réussis pas » : une perspective psychodynamique
Authors: Brécard France 
Published: September 2014

Dans cet article mon intention est de parler de l’injonction « Ne réussis pas » et de son diagnostic. Dans le cours de mon expérience de psychothérapeute, j’ai souvent accompagné des personnes dont la problématique venait de ce message inhibiteur. En travaillant avec ces patients, je me suis aperçue que ce message et la décision qui en résultait trouvent leur origine à des étapes différentes du développement de la personne. Cet article a pour objectif de montrer comment, à chaque étape de son développement, l’enfant est ou non en contact avec la permission de réussir. Et comment l’injonction « Ne réussis pas » se manifeste de façon différente suivant le moment où l’enfant l’a intégrée. F.B.
Théorie des jeux psychologiques et niveaux de défense : une présentation de cas
Authors: Woods Ken , Grégoire José 
Published: September 2014

Cet article illustre les théories exposées dans le précédent à propos des trois strates de défense dans la condition névrotique à propos d’un homme présentant des troubles du comportement sexuel et une confusion quant à son identité sexuelle. La démarche allie trois démarches qui se complètent : l’analyse des jeux psychologiques dans le présent, telle que l’article précédent l’a élaborée, celle du passé scénarique et celle des interactions et de la communication inconsciente entre thérapeute et patient. Une attention particulière est donnée aux moments où le thérapeute réagit à la pathologie par une autre pathologie et se laisse entraîner vers les jeux psychologiques. J.G.
Le traitement des troubles de l'alimentation par l'A.T.
Authors: Brunt Mervyn , Grégoire José 
Published: September 2014

L’article rappelle les données de recherche montrant l’efficacité des approches de type cognitif-comportemental ou interpersonnel pour les troubles de l’alimentation. Il en détaille les causes multiples, les difficultés spécifiques et la nécessité parfois vitale d’un accompagnement médical. A partir d’une illustration par un cas, il explore les diagnostics transactionnels des personnes qui en souffrent et énumère les étapes du traitement : établissement de la relation, contrat, décontamination, déconfusion, construction d’un nouveau Parent, fluidité émotionnelle, redécision, nouvel apprentissage. J.G.
Théorie de l'intersubjectivité et transactions non-verbales
Authors: Hargaden Helena , Fenton Brian , Grégoire José 
Published: September 2014

Sur le fondement des recherches récentes sur l’intersubjectivité et de l’orientation relationnelle récente des psychanalyses, l’article examine la notion d’intersubjectivité et ses conséquences pour la thérapie au niveau préverbal des relations et des transactions. L’intersubjectivité renvoie à une « psychologie à deux personnes » (par opposition à la psychologie individuelle en vigueur du temps de Freud et de Berne), en mettant en lumière le rôle essentiel de la dimension interactive de la relation dans la croissance comme dans l’ici et maintenant. Des deux côtés, la relation est donc « plus riche que la somme des partenaires ». L’intersubjectivité primaire, qui se développe de la naissance à 6 mois, est caractérisée par la perception qu’ont les partenaires, à l’origine la mère et le nourrisson, de leur vécu réciproque : elle implique un véritable « partage de mental à mental » à travers un espace intermédiaire commun (parfois dénommé « troisième subjectivité »). C’est à partir d’elle que se constituent non seulement l’intersubjectivité secondaire, mais aussi la pensée (qui est donc dès le départ « co-pensée »), le langage et le sens de Soi. L’intersubjectivité secondaire, qui se développe de 6 à 12 mois, permet d’élargir la relation pour tourner l’attention ou l’activité commune vers une personne ou une chose externes. Dans la thérapie, c’est au niveau de l’intersubjectivité primaire, qui reste toujours sous-jacente au processus, que s’opèrent les changements véritables au niveau du sens de Soi ; il est donc capital que le thérapeute perçoive et prenne en compte cette dynamique préverbale, émotionnelle et inconsciente, à laquelle il a accès par l’examen de son propre vécu (contre-transfert), à condition de se permettre d’être « changé » émotionnellement par le client dans son voyage de découverte avec lui. J.G.