bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication choice and psychosis Hospital readmissions: A two-year comparative study
Authors: Martin-Santiago O. , Calvo-Valcarcel M. , Martinez.Gimeno P. , Alario-Ruiz C. , Arribas-Simon B. 
Published: August 2024

IntroductionHospital readmissions in psychosis are a critical concern, with medication choice playing a vital role. Oral antipsychotics, though common, rely on patient adherence and can lead to relapses if not followed. Long-acting injectable atypical antipsychotics (LAIAs) provide an alternative, ensuring consistent medication release and reducing relapse risk due to missed doses. Studies indicate that LAIAs result in fewer readmissions due to improved adherence. Tailoring treatment to individual needs is essential. Medication choice significantly influences hospital readmission prevention in psychosis. LAIAs, which could offer greater adherence to treatment and symptom control, present a promising option. Individualized treatment decisions are a priority for long-term recovery.ObjectivesThis study aimed to compare the hospital readmission rates within two years post-discharge among two groups of patients diagnosed with schizophrenia and other psychotic disorders who received either oral antipsychotic treatment or LAIAs.MethodsWe collected sociodemographic and hospitalization data from 155 patients, 90 receiving oral antipsychotics and 65 receiving LAIAs, following their discharge from a psychiatric unit.ResultsThere were 90 patients in the oral treatment group, and 65 in the LAIA group, with 67.6% receiving paliperidone and 26.1% receiving aripiprazole. There were no significant differences in age or gender between the two groups. However, patients in the LAIA group had longer stays in the hospital (M=14.7; SD=10.2 vs M=11.1; SD=6.4; t(153)=2.67; p<.01) and a higher number of prior admissions (M=3.2; SD=3.7 vs M=1.3; SD=3.5; t(153)=2.41; p<.01) compared to the oral antipsychotic group. Additionally, a higher percentage of patients in the LAIA group were diagnosed with schizophrenia (60%) compared to the oral antipsychotic group (24%) (X2(1, N = 155)= 20.4, p<.01). After two years, readmission rates were 66.6% for the oral antipsychotic group and 61.5% for the LAIA group (X2(1, N = 155)= 8.5, p > .05). However, the time to readmission was shorter for patients on oral antipsychotics (M=172.4; SD=162.0) compared to those on LAIAs (M=326.2; SD=211.4; t(153)=3.05; p<.01). Notably, 86.6% of patients on oral antipsychotics were readmitted within the first year, while only 52% of those on LAIAs experienced readmission during the same period (X2(1, N = 155)= 8.5, p = .001).ConclusionsLong-acting injectable antipsychotics (LAIAs) appear to reduce hospital readmissions, with a more pronounced effect in the first few months post-discharge. However, after two years, the readmission rates between LAIAs and oral antipsychotics become comparable. This data suggests that while LAIAs may reduce early readmissions, their long-term effectiveness is on par with oral antipsychotics.Disclosure of InterestNone Declared
Sleep disorders and addiction A study of 100 patients
Authors: Bensalah Y. , Sabir M. , Elomari F. 
Published: August 2024

IntroductionSeveral studies have demonstrated a high prevalence of sleep-related complaints in subjects with an addiction to psychoactive substances (alcohol, cannabis, nicotine, cocaine)Sleep disorders negatively influence the quality of life of subjects suffering from addiction and increase the risk of relapseObjectivesTo assess the prevalence of sleep disorders in patients with problematic use of psychoactive substances as well as associated factorsMethodsThis is a descriptive and analytical cross-sectional study carried out among 100 patients followed at Ar-Razi hospital Salé in Morocco for problematic use of psychoactive substances from June 1 to August 30, 2023A questionnaire was used assessing the socio-demographic and clinical characteristics of our populationSleep quality was assessed by the Pittsburgh Scale (PSQI)ResultsThere were 100 patients, with ages ranging from 18 to 56 years old and the majority of whom were males.History of somatic pathology was reported in 36% of patientsThe majority of patients had an associated anxiety disorder (60%)The most consumed psychoactive substances were tobacco (95%), followed by cannabis, benzodiazepines and alcohol.75% of patients reported poor sleep qualityThere was a statistically significant difference between the risk of relapse and the reduction in sleep qualityConclusionsThe prevalence of poor sleep quality in patients with disorders linked to psychoactive substance use is high, hence the importance of early detection in order to improve treatment.Disclosure of InterestNone Declared
Enhancing Quality of Life in the Elderly: The Impact of Psychosomatic Exercises on Healthy Aging
Authors: Argyropoulos K. , Sfakianaki R. , Argyropoulou A. , Avramidis D. , Gourzis P. , Jelastopulu E. 
Published: August 2024

IntroductionOlder individuals constitute a significant portion of the population, and concerted efforts are underway to enhance the quality of this life stage by minimizing health issues and maximizing opportunities.ObjectivesThis study aims to investigate the impact of psychosomatic exercises, including practices like yoga, meditation, and tai chi, as an alternative approach to promoting healthy aging and ultimately enhancing the quality of life among elderly individuals.MethodsThe study comprised 84 participants, with 51 individuals engaging in various forms of psychosomatic exercises and 33 serving as the control group, having no prior exposure to such practices. Data collection was carried out electronically, with the initial section gathering socio-demographic information and health-related details about the participants. The second part consisted of the WHOQOL-BREF quality of life scale, consisting of 26 questions, which assessed six domains: Overall Quality of Life and General Health, Physical Health, Psychological Health, Social Relationships, and Environment. Statistical analysis was performed with SPSS 26.ResultsThe average age of the participants was 66.7 years. A statistically significant positive correlation was identified within the first subscale of the tool, “Overall Quality of Life and General Health,” with scores of 74.3/100 for those engaging in psychosomatic exercises and 66.7/100 for those who did not (t(82) = -2.513, p = 0.014). However, no statistically significant differences were observed in the remaining subscales.ConclusionsPsychosomatic exercises, including yoga, meditation, and tai chi, hold promise as a means to improve the overall quality of life and general health of elderly individuals. These practices could serve as valuable components of strategies aimed at promoting healthy aging. Further research is needed to explore their effects in greater detail and across various dimensions of well-being.Disclosure of InterestNone Declared
The possible role of platelet APP processing in the pathophysiology of Alzheimer’s Disease
Authors: Gurrieri R. , Carbone M. G. , Arone A. , Palermo S. , Marazziti D. , Gemignani A. 
Published: August 2024

IntroductionAlzheimer’s disease (AD) stands as the most prevalent form of dementia. Alzheimer’s Disease is acknowledged to have a complex origin, a gradual neurodegenerative progression, and a wide-ranging clinical profile marked primarily by progressive memory loss, cognitive decline, and various functional impairments that significantly diminish the quality of life: Key characteristics of AD encompass the presence of amyloid plaques, which are characterized by the pathological accumulation of insoluble β-amyloid (Aβ) aggregates within the brain tissue and blood vessel walls.Several reports have indicated the existence of cerebral abnormalities within platelets in individuals afflicted by AD.ObjectivesThe objective of this investigation was to review studies investigating the metabolism of APP in platelets among individuals with AD to identify potential dependable peripheral indicators leading to novel approaches to its management and treatment.MethodsA systematic review according to the PRISMA guidelines was carried out, by accessing the PubMed database up to June 2023. The authors screened the titles and the abstracts of all the potentially relevant papers on the basis of a strict list of exclusion and inclusion criteria.ResultsA total of thirty-two studies were included. The evidence points towards the observation that AD individuals exhibit various modifications in platelet APP processing when compared to matched healthy controls, that are frequently associated with the severity of cognitive impairment and functional independence. The majority of the evidence supports changes in platelet ADAM-10 activity, β-secretase activity, APP ratio, a state of heightened platelet activation or hyper-responsiveness, and a potential release of platelet APP via vesicular mechanisms, which may ultimately contribute to Aβ production.ConclusionsPlatelets offer a promising peripheral model for detecting and evaluating molecular changes associated with AD, as they hold the potential to provide vital insights into the development of an effective diagnostic tool and open doors to innovative therapeutic approaches.Disclosure of InterestNone Declared
Sociodemographic factors as a predictor for pregnancy-related anxiety
Authors: Abdelkefi M. , Walha R. , Feki R. , Zid W. , Gassara I. , Smaoui N. , Omri S. , Charfi N. , Zouari L. , Ben Thabet J. , Maalej Bouali M. , Chaabene K. , Maalej M. 
Published: August 2024

IntroductionPregnant women are particularly vulnerable to a wide variety of psychiatric symptoms, including anxiety related to pregnancy and childbirth.ObjectivesThe purpose of our study was to determine the sociodemographic characteristics of pregnant women and investigate their relationship with pregnancy-related anxiety.MethodsThe study was conducted from February to July 2023 among pregnant women in their 3rd-trimester consulting at the Gynecology-obstetrics department of the Hedi Chaker University Hospital of Sfax, Tunisia. Women with obstetric conditions favorable to vaginal delivery (cephalic presentation and eutrophic fetus) were interviewed using a questionnaire including their sociodemographic characteristics and the brief version of the pregnancy-related anxiety questionnaire PRAQ-R2.ResultsA total of 350 women were included in our study. The mean age of the participants was 28 years [16-41 years] with the majority being married (95.7%). One hundred and eighty-eight women (53.7%) did not graduate from high school and 213 (60.9%) were housewives. Half of the participants (52.9%) lived in the city, and 38.9% reported low income. Almost half of them (46.28%) were multiparous.The mean score of the PRAQ-R2 was 31.24 ± 7.53.We found a positive correlation between the PRAQ-R2 scale score and age younger than 30 years (p<0.001), low educational level (p=0.006), and low income (p=0.031).ConclusionsOur findings suggest that demographic factors seem to predict anxiety related to pregnancy and are worth examining in future studies for a better understanding of this symptom in pregnant women.Disclosure of InterestNone Declared
Who Is Right? Behavioral Problems from the Perspectives of Parents and Children with ADHD symptoms
Authors: Sitnik-Warchulska K. , Izydorczyk B. , Markevych I. , Szwed M. , Sawicki A. , Lipowska M. 
Published: August 2024

IntroductionDiagnosing behavioral problems in children and adolescents, which include conduct symptoms, anxiety, or somatic complaints, is frequently based on subjective perceptions and interviews with family or caregivers. However, current theoreticians and practitioners of systemic theory are increasingly emphasizing that there are multiple subjective narratives about oneself, the world, and one’s symptoms. The question is whether these narratives are equivalent, and if not, under what circumstances do they diverge?ObjectivesThe study aimed to investigate whether the perception of behavioral problems among young adolescents with ADHD aligns with their parents’ perspective, and whether family bonding is a factor in this association.MethodsThe analytic sample comprised about 200 children, aged 10-14 years, and their parents, mostly coming from well-situated families. The data were collected as a part of the NeuroSmog project. The variables were measured by the Child Behaviour Checklist (CBCL), the Youth Self Report (YSR), the Family Adaptation and Cohesion Evaluation Scales (FACES-IV). The structural equation modelling (SEM) to analyse data was used. The models were also stratified by age, sex, and social status.ResultsThere is a significant difference between the perspectives of parents and children regarding the level of behavioral problems. Family bonding is associated with behavioral problems among children, but this relationship is only evident from their perspective.ConclusionsThe perception referring to family narratives has the most significant impact on individual functioning.Disclosure of InterestNone Declared
Clinical / Therapeutic Name: Care and treatment of prisoners with intellectual disabilities
Authors: Tort Herrando V. ,   Forensic Psychiatric Section
Published: August 2024

AbstractCare and treatment of prisoners with intellectual disabilities I will describe what is the care, from different points of view when an offender with intelledtual disabilities entry in the penitentiary system. As a vulnerable population, people with intellectual disabilities have to be treated in a more specific manner, and both prison managers and clinciacal staff have to be aware of of that. This prisoners, sometimes, also belongs to another vulnerable population ( illegal inmigration, fenmales, ehtnic groups ,etc) that make this cases as a complex ones. The care have to be as a comprehensive, with thr higest standards of care a nd avoid neglicence en treating this cases. We have to emphasize about rehablitation and a goodl coordnation with the intellectual disability community services to avoid relapse and recidivismDisclosure of InterestNone Declared
Social determinants of involuntary psychiatric hospital admissions in Ontario, Canada
Authors: Fung K. P. , Kim S. 
Published: August 2024

IntroductionIn Ontario, Canada, patients may be admitted to the hospital involuntarily if they are deemed to be suffering from symptoms of a mental disorder that may result in imminent serious bodily harm to themselves or others, or that may cause serious physical impairment to themselves (e.g., inability to keep themselves safe and warm in the winter). This measure can be life-saving. However, in addition to ethical and human rights considerations, resorting to coercive admissions may be an indication that those who are suffering from mental illness are not able to access or receive timely and appropriate intervention. While recent studies have suggested that the rate of involuntary hospital admission may be increasing, data on social determinants of involuntary hospital admissions are limited.ObjectivesWe examined social factors associated with involuntary admissions using a Canadian provincial database.MethodsBinary logistic regression models were conducted to examine the associations between social factors (low income, indigeneity, rurality, housing type) and involuntary admissions, controlling for age, sex, and psychiatric diagnoses. Data from March 2019 to March 2021 was extracted from the Ontario Mental Health Reporting System admission dataset, comprising of a sample of 9,848 patients admitted to eight psychiatric hospitals in Ontario. Odds ratios and 95% confidence intervals are reported.ResultsIn 2021, the proportion of involuntary patients increased significantly by 6.8 percentage points to 55.7% compared to the previous year (48.9%). Indigenous status (First Nations, Metis, Inuit) [1.75 (1.38-2.21) **], living in rural areas [2.78 (2.48-3.12)], living in assisted residence [1.41 (1.21-1.64) **], homelessness [1.63 (1.38-1.91) **], male sex [1.21 (1.10-1.33) **] and younger age [0.99 (0.98-0.99) **] were associated with involuntary admissions, while income was not a significant factor. Compared to a diagnosis of a psychotic disorder, substance use disorders [0.11 (0.10-0.13) **] and mood and anxiety disorders [0.32 (0.29-0.36) **] showed decreased odds of involuntary admission, while neurocognitive disorders increased the odds of involuntary admission [3.86 (2.91-5.11) **].ConclusionsConsistent with other findings, involuntary psychiatric hospital admissions in ON, Canada, have increased recently, which may in part be related to the pandemic. Rurality, indigenous status, and unstable housing have been found to be associated with involuntary admissions. The study findings support the need for better preventive and intervention strategies to serve vulnerable psychiatric patients, including addressing the social determinants of health such as housing, and increasing access to culturally competent and safe community-based mental health supports and services.Disclosure of InterestNone Declared
Comparison of Val66met Polymorphism of BDNF gene in patients of bipolar disorder and healthy controls.
Authors: Srikantamurthy M. , Moirangathem S. , Viswanath B. , Purushottam M. , Jain S. 
Published: August 2024

IntroductionThe study aims to explore the utility of BDNF Val66Met polymorphism as a potential biomarker in Indian bipolar disorder patients and its correlation with clinical characteristics.ObjectivesGenotyping Val66Met in BDNF geneExploring its association with bipolar disorder (BD).Methods150 consenting BD patients and matched controls were recruited using a case-control study design. BD severity was assessed using Young’s mania rating scale and the Clinical Global Impression - Severity (CGI-S) scale. BDNF Val66Met polymorphism was identified through real-time PCR after DNA extraction. Data was tested for normal distribution. Genotype frequencies between two groups were compared and the Hardy-Weinberg equilibrium assumptions were tested using Chi-Square tests. Clinical-genotypic associations were explored using the Kruskal-Wallis test and confirmed using hierarchical regression.ResultsOur sample had more males (60%) than females (40%) with mean age of 35.05 years. Most patients had established bipolar disorder and were severely ill (CGI: 38.75, YMRS). Val66Met SNP genotype frequency differed significantly between cases and controls. Val66Val genotype and Val allele were higher in cases. Results consistent with Hardy-Weinberg equilibrium.Table 1.Genotype frequencies of BDNF (rs6265) in cases and controlsGENOTYPECCCTTTCASES94(62.6%)47(31.3%)9(6%)CONTROL71(47.3%)69(46%)10(6.6%)CHI-SQUARE-
7.431DF(Degree of freedom) - 2p-value- 0.024Table 2.Dominant genotype frequencies in cases and controlsDOMINANT GENOTYPECCCT+TTCASES94(62.6%)56(37.3%)CONTROLS71(47.3%)79(52.6)CHI-SQUARE-7.125DF(Degree of freedom)-1p-value-0.007Table 3.Allelic frequencies of BDNF (rs6265) in BD cases and healthy controlsALLELIC VARIATIONCTCASES235(78.3%)65(21.6%)CONTROLS211(70.3%)89(29.6%)CHI-SQUARE-5.032DF(Degree of freedom)-1p-value- 0.024ConclusionsOur study found that Val66Val genotype and Val allele were higher in cases and could be a potential biomarker for bipolar disorder (BD), which is consistent with previous research conducted on the European population. However, further investigations are required to gain a more comprehensive understanding of its impact on BD, including its association with serum BDNF levels, treatment outcomes, and a more diverse study population.Disclosure of InterestNone Declared
Pharmacogenomics in Psychiatry: An Asian Perspective
Authors: Goh S. E. 
Published: August 2024

IntroductionPharmacogenomic testing in psychiatry is an emerging area with the potential clinical application of guiding medication choice and dosing. However, this has not been adopted widely due to a combination of barriers that include a varying evidence base, clinician and patient familiarity and acceptance, uncertainty about cost-effectiveness, and regulatory requirements.ObjectivesThis review aims to examine recent updates in this field and provide a contextualised summary and recommendations for Asian populations. The recommendations serve to guide healthcare professionals in the utility of pharmacogenomic testing in psychiatric practice.MethodsA review of recent literature about current evidence and guidelines surrounding pharmacogenomics in psychiatric practice was carried out with particular attention paid to literature evaluating Asian populations. Literature was reviewed for the different classes of psychotropics with supplementary information about Asian populations included where available. Existing evidence about combinatorial pharmacogenomic panels was also reviewed.ResultsIn line with the available body of evidence, we recommend that pharmacogenomic testing should be employed as an augmenting tool to guide medication selection and dosing in certain clinical situations, and not as part of standard or routine clinical practice. Pharmacogenomic testing should also be mainly limited to the known drug-gene pairs such as the anti-depressants and CYP2C19 or CYP2D6. Clinicians should also be aware that many of the gene-drug associations have not been evaluated for clinical outcomes. Combinatorial pharmacogenomic panels are not presently recommended as there is limited and inconclusive available evidence on clinical outcomes.ConclusionsPharmacogenomic testing in psychiatry is not recommended as standard or routine clinical practice. Exceptions may include concerns about drug concentrations (due to metaboliser status) or potential severe adverse drug reactions/ Pharmacogenomic testing should be mainly limited to the known drug-gene pairs such as the anti-depressants and CYP2C19 or CYP2D6.Disclosure of InterestNone Declared