bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of type 2 diabetes mellitus and hypertension in patient’s visiting the conservative dentistry and endodontics department: a cross-sectional study in Surabaya City
Authors: Manihar Meet , Wahjuningrum Dian Agustin , Manihar Shreya , Pawar Ajinkya M. , Atram Jatin , Banga Kulvinder , Luke Alexander Maniangat , Elmsmari Firas 
Published: June 2024

Background
This descriptive cross-sectional study focuses on the prevalence of hypertension (HTN) and type 2 diabetes mellitus (T2DM) amongst patients who visited the Conservative Dentistry and Endodontics department. Recognizing these incidence statistics is critical for improving endodontic therapy delivery and assuring high-quality dental care with positive treatment outcomes.

Methods
In advance of getting dental care, all patients visiting the department were advised to get their blood sugar and blood pressure levels checked at random. Measurements were taken with digital equipment, and individuals with high levels were encouraged to seek medical advice before undergoing dental procedures. The obtained data was imported into Excel and analyzed with IBM SPSS software (version 21).

Results
The investigation had 1,100 participants (55.8% female and 44.2% male), with an average age of 44.58 ± 12.77 years. Of the individuals, 40.6% were referred for type 2 diabetes, 12.6% for hypertension, and 24.0% for both diseases. There was a significant correlation (p < 0.05) between referral status and gender. The average blood pressure and random blood sugar readings were 141.02 mmHg ± 56.28 mmHg (systolic), 79.83 mmHg ± 10.68 mmHg (diastolic), and 126.68 mg/dL ± 15.36 mg/dL, respectively. There was a substantial (p < 0.05) difference in mean systolic blood pressure between men and women. Furthermore, age was strongly connected with random blood sugar levels (p < 0.05) and systolic and diastolic blood pressure (p < 0.05). There were significant (p < 0.05) variations in mean blood pressure and blood sugar levels between referred and non-referred individuals.

Conclusion
Age had a relationship with higher random blood sugar levels, systolic blood pressure, and diastolic blood pressure. Dentists should consider patient age while planning treatment, as type 2 diabetes mellitus and hypertension require unique techniques to emphasize patient safety and produce excellent outcomes.
Creatine kinase mitochondrial 2 promotes the growth and progression of colorectal cancer via enhancing Warburg effect through lactate dehydrogenase B
Authors: Cai Shasha , Xia Qingqing , Duan Darong , Fu Junhui , Wu Zhenxing , Yang Zaixing , Yu Changfa 
Published: June 2024

Background
Mitochondrial creatine kinase (MtCK) plays a pivotal role in cellular energy metabolism, exhibiting enhanced expression in various tumors, including colorectal cancer (CRC). Creatine kinase mitochondrial 2 (CKMT2) is a subtype of MtCK; however, its clinical significance, biological functions, and underlying molecular mechanisms in CRC remain elusive.

Methods
We employed immunohistochemical staining to discern the expression of CKMT2 in CRC and adjacent nontumor tissues of patients. The correlation between CKMT2 levels and clinical pathological factors was assessed. Additionally, we evaluated the association between CKMT2 and the prognosis of CRC patients using Kaplan-Meier survival curves and Cox regression analysis. Meanwhile, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the expression levels of CKMT2 in different CRC cell lines. Finally, we explored the biological functions and potential molecular mechanisms of CKMT2 in CRC cells through various techniques, including qRT-PCR, cell culture, cell transfection, western blot, Transwell chamber assays, flow cytometry, and co-immunoprecipitation.

Results
We found that CKMT2 was significantly overexpressed in CRC tissues compared with adjacent nontumor tissues. The expression of CKMT2 is correlated with pathological types, tumor size, distant metastasis, and survival in CRC patients. Importantly, CKMT2 emerged as an independent prognostic factor through Cox regression analysis. Experimental downregulation of CKMT2 expression in CRC cell lines inhibited the migration and promoted apoptosis of these cells. Furthermore, we identified a novel role for CKMT2 in promoting aerobic glycolysis in CRC cells through interaction with lactate dehydrogenase B (LDHB).

Conclusion
In this study, we found the elevated expression of CKMT2 in CRC, and it was a robust prognostic indicator in CRC patients. CKMT2 regulates glucose metabolism via amplifying the Warburg effect through interaction with LDHB, which promotes the growth and progression of CRC. These insights unveil a novel regulatory mechanism by which CKMT2 influences CRC and provide promising targets for future CRC therapeutic interventions.
Effect of Site Specific N Management and Different Crop Establishment Methods on Tillering Ability and Dry Matter Accumulation in Rice
Authors: Naik Sugali Nanu Abhilash , Chandrasekhar K. , Tuti Mangal Deep , Surekha K. , Latha P.C. 
Published: June 2024

Rice (Oryza sativa L.) is the second most important staple food crop of world and prime staple food crop of India. Rice (Oryza sativa L.) and rice-based cropping systems are integral part of agriculture whose spread and extent is predominant across the countries. The productivity and sustainability of rice-based systems are threatened by the inefficient use of inputs (fertilizer), increasing scarcity of especially water, climate variability and availability of labour. Method of establishment and N management practices influences the performance of rice through its effect on growth and development. A field experiment was conducted during kharif 2021-22 and 2022-23 at ICAR-Indian Institute of Rice Research, Rajendranagar, Hyderabad to study the “Effect of site specific N management and different crop establishment methods on tillering ability and dry matter accumulation in rice”.The experiment was laid out in split plot design with three crop establishment methods [Manual transplanting (M1) mechanical transplanting (M2) and wet direct seeded rice (M3)] in main plots and five nitrogen management practices [S1- Recommended nitrogen dose (RND), S2-Leafcolorchart (LCC), S3-Nutrient Expert (NE), S4-Greenseeker (GS), S5-Soil test crop Response STCR] in sub-plots with three replications. The results revealed that under crop establishment methods, mechanical transplanting recorded higher tiller bearing capacity per m-2 (384,446 and 415 m-2) as well dry matter production (kg ha-1) (13927, 14395 and 14161) while in nitrogen management practices soil test crop response STCR recorded higher tiller production ability per m-2 (414,468 and441m-2) and drymatterproductio (kg ha-1) (13949, 14772 and 14360 kg ha-1). The results suggest that timely transplanting of younger seedlings, appropriate N management practice based on STCR achieved better crop stand with higher tillering ability and dry matter production efficiency.
Erratum: Note of correction: “Laplace approximations to posterior moments and marginal distributions on circles, spheres, and cylinders”
Authors: Bagchi Parthasarathy , Kadane Joseph B. 
Published: November 2012

AbstractWe thank Koffi Eddy Ihou and Adrian M. Peter of Florida Institute of Technology, for bringing the following errors to our attention. The Canadian Journal of Statistics 40: 770–771; 2012 © 2012 Statistical Society of Canada
Human‐induced marine ecological degradation: micropaleontological perspectives
Authors: Yasuhara Moriaki , Hunt Gene , Breitburg Denise , Tsujimoto Akira , Katsuki Kota 
Published: November 2012

AbstractWe analyzed published downcore microfossil records from 150 studies and reinterpreted them from an ecological degradation perspective to address the following critical but still imperfectly answered questions: (1) How is the timing of human‐induced degradation of marine ecosystems different among regions? (2) What are the dominant causes of human‐induced marine ecological degradation? (3) How can we better document natural variability and thereby avoid the problem of shifting baselines of comparison as degradation progresses over time? The results indicated that: (1) ecological degradation in marine systems began significantly earlier in Europe and North America (~1800s) compared with Asia (post‐1900) due to earlier industrialization in European and North American countries, (2) ecological degradation accelerated globally in the late 20th century due to post‐World War II economic growth, (3) recovery from the degraded state in late 20th century following various restoration efforts and environmental regulations occurred only in limited localities. Although complex in detail, typical signs of ecological degradation were diversity decline, dramatic changes in total abundance, decrease in benthic and/or sensitive species, and increase in planktic, resistant, toxic, and/or introduced species. The predominant cause of degradation detected in these microfossil records was nutrient enrichment and the resulting symptoms of eutrophication, including hypoxia. Other causes also played considerable roles in some areas, including severe metal pollution around mining sites, water acidification by acidic wastewater, and salinity changes from construction of causeways, dikes, and channels, deforestation, and land clearance. Microfossils enable reconstruction of the ecological history of the past 102–103 years or even more, and, in conjunction with statistical modeling approaches using independent proxy records of climate and human‐induced environmental changes, future research will enable workers to better address Shifting Baseline Syndrome and separate anthropogenic impacts from background natural variability.
Dust modelling using a combined CFD and discrete element formulation
Authors: Hilton J. E. , Cleary P. W. 
Published: November 2012

SUMMARYThe production and dispersal of airborne dust is an important issue in both environmental and industrial contexts. Dust pollution is a major environmental concern, and long exposure in occupational settings has been linked with numerous respiratory health issues. Industrial dust pollution can also present a significant explosion hazard, even in facilities with dust extraction systems. Computational models for dust generation and dispersal have, however, generally been formulated for specific geophysical applications and restricted to static, two‐dimensional, approaches. Here, we present a method for simulating dust production from a dynamic granular bed by using a three‐dimensional coupled discrete element method and Navier–Stokes computational model. Dust production is based on an energy formulation in which micro‐scale dust particles are assumed to overcome cohesion to macro‐scale grains. This model is used over the entire range of energies present within the system, from macro‐scale collisions to aerodynamic entrainment and bombardment of micro‐scale particles. The dust concentration is modelled as a scalar density field, which is advected and diffused through turbulence in the gas flow field. The model is tested against empirical predictions for two test cases, a slug of granular material dropped from a set height and air flow over a granular stockpile. Both give good agreement to the empirical relations, showing that the model can accurately predict the production and subsequent dispersal of dust from a dynamic granular bed. Copyright © 2012 John Wiley & Sons, Ltd.
A semi‐implicit scheme for 3D free surface flows with high‐order velocity reconstruction on unstructured Voronoi meshes
Authors: Boscheri W. , Dumbser M. , Righetti M. 
Published: November 2012

SUMMARYIn this paper, we present a computationally efficient semi‐implicit scheme for the simulation of three‐dimensional hydrostatic free surface flow problems on staggered unstructured Voronoi meshes. For each polygonal control volume, the pressure is defined in the cell center, whereas the discrete velocity field is given by the normal velocity component at the cell faces. A piecewise high‐order polynomial vector velocity field is then reconstructed from the scalar normal velocities at the cell faces by using a new high‐order constrained least‐squares reconstruction operator. The reconstructed high‐order piecewise polynomial velocity field is used for trajectory integration in a semi‐Lagrangian approach to discretize the nonlinear convective terms in the governing PDE. For that purpose, a high‐order Taylor method is used as ODE integrator. The resulting semi‐implicit algorithm is extensively validated on a large set of different academic test problems with exact analytical solution and is finally applied to a real‐world engineering problem consisting of a curved channel upstream of two micro‐turbines of a hydroelectric power plant. For this realistic case, some experimental reference data are available from field measurements. Copyright © 2012 John Wiley & Sons, Ltd.
Hydrothermolysis of carbohydrates to levulinic acid using metal supported on porous aluminosilicate
Authors: Suacharoen Sirinart , Tungasmita Duangamol Nuntasri 
Published: November 2012

AbstractBACKGROUNDAluminosilicate catalysts have the potential to promote the formation of oxygenated derivatives from carbohydrates in a hydrothermolysis reaction. Levulinic acid (LA) can be obtained from glucose, sucrose and starch hydrothermolysis reactions, and is a very versatile building block for diverse organic synthetic compounds. In this work, the catalytic performance of Ni‐ or Ru‐doped aluminum‐loaded SBA‐15 (Al‐SBA‐15) was compared with ZSM‐5 catalyst in order to achieve high LA selectivity.RESULTSAll catalytic hydrothermolysis reactions tested gave remarkably higher LA selectivity than non‐catalytic reactions for every carbohydrate substrate used. The acid contents and porous properties are important keys to control yield and selectivity of LA. The highest selectivity of LA (44%) was attained from glucose hydrothermolysis at 200 °C (for 1 h) using a 15 wt% loading of the 20 wt% Ru‐doped ZSM‐5 catalyst.CONCLUSIONModerately raising Ru in ZSM‐5 and Al‐SBA‐15 catalysts increased the levels of LA. The MFI structure of ZSM‐5 is suitable for hydrothermolysis of glucose monosaccharide, while the hexagonal mesoporous structure of Al‐SBA‐15 is preferred for starch polysaccharide hydrothermolysis at the optimum condition. © 2012 Society of Chemical Industry
35Cl NQR frequency and spin lattice relaxation time in 3,4‐dichlorophenol as a function of pressure and temperature
Authors: Ramu L. , Ramesh K. P. , Chandramani R. 
Published: November 2012

The pressure dependences of 35Cl nuclear quadrupole resonance (NQR) frequency, temperature and pressure variation of spin lattice relaxation time (T1) were investigated in 3,4‐dichlorophenol. T1 was measured in the temperature range 77–300 K. Furthermore, the NQR frequency and T1 for these compounds were measured as a function of pressure up to 5 kbar at 300 K. The temperature dependence of the average torsional lifetimes of the molecules and the transition probabilities W1 and W2 for the Δm = ±1 and Δm = ±2 transitions were also obtained. A nonlinear variation of NQR frequency with pressure has been observed and the pressure coefficients were observed to be positive. A thermodynamic analysis of the data was carried out to determine the constant volume temperature coefficients of the NQR frequency.An attempt is made to compare the torsional frequencies evaluated from NQR data with those obtained by IR spectra. On selecting the appropriate mode from IR spectra, a good agreement with torsional frequency obtained from NQR data is observed. The previously mentioned approach is a good illustration of the supplementary nature of the data from IR studies, in relation to NQR studies of compounds in solid state. Copyright © 2012 John Wiley & Sons, Ltd.
Weighted control with ‐stability constraint for switched positive linear systems
Authors: Tong Yanhui , Zhang Lixian , Basin Michael , Wang Changhong 
Published: November 2012

SUMMARYThis paper is concerned with the problem of control with ‐stability constraint for a class of switched positive linear systems. The ‐stability means that all the poles of each subsystem of the resultant closed‐loop system belong to a prescribed disk in the complex plane. A sufficient condition is derived for the existence of a set of state‐feedback controllers, which guarantees that the closed‐loop system is not only positive and exponentially stable with each subsystem ‐stable but also has a weighted performance for a class of switching signals with average dwell time greater than a certain positive constant. Both continuous‐time and discrete‐time cases are considered, and all of the obtained conditions are formulated in terms of linear matrix inequalities, whose solution also yields the desired controller gains and the corresponding minimal average dwell time. Numerical examples are given to illustrate the effectiveness of the presented approach.Copyright © 2012 John Wiley & Sons, Ltd.
Roughness statistical influence on cell adhesion using profilometry and multiscale analysis
Authors: Giljean Sylvain , Bigerelle Maxence , Anselme Karine 
Published: November 2012

SummaryIn this study, two series of 11 samples of TiAl6V4 titanium alloy and 316L stainless steel have been polished in an isotropic manner at different levels in order to quantify the influence of biomaterial roughness on cell behavior. Topography was measured by a tactile profilometer and a multiscale analysis has been carried out. Human osteoblasts have been cultured on those samples. It appears that roughness has no reproducible effect on the cell behavior except an influence on cell orientation on the wider grooves. As a conclusion, biomaterial surface damage, in the roughness range betweenRa= 0.01 and 0.1 μm, has no influence on cell‐adhesion mechanisms when roughness is isotropic and groove width is inferior to a critical value. SCANNING 36:2–10, 2014. © 2012 Wiley Periodicals, Inc.
Computational methods for contemporary carbene chemistry
Authors: Gerbig Dennis , Ley David 
Published: November 2012

AbstractThe use of computational methods in carbene chemistry has a long‐standing tradition. Indeed, the field has come a long way since the first ab initio calculations on methylene. Computations now routinely accompany most experimental studies, either to validate the obtained results or to help design appropriate experiments. Advances in computational carbene chemistry within the last decade are covered in this text, encompassing a plethora of studies on alkyl‐, aryl‐, halo‐, and heterocarbenes (N, P, O, S) as well as on persistent triplet carbenes. Moreover, the conceptual advancements in the fields of theoretical chemistry and computing technology have enabled researchers to conduct intricate ab initio studies. The application of leading‐edge theory to multireference problems, high‐accuracy thermochemical evaluations, atom tunneling, and the description of bonding is thoroughly reviewed. In addition, general recommendations for the choice of an appropriate method for a specific computational problem are given. Practitioners of the art are likely to discover new computational approaches in carbene chemistry applied to various examples from the current literature. © 2012 John Wiley & Sons, Ltd.This article is categorized under:

Electronic Structure Theory > Ab Initio Electronic Structure Methods
Bioconversion ofAgave tequilanafructans by exo-inulinases from indigenousAspergillus nigerCH-A-2010 enhances ethanol production from rawAgave tequilanajuice
Authors: Huitrón Carlos , Pérez Rosalba , Gutiérrez Luís , Lappe Patricia , Petrosyan Pavel , Villegas Jesús , Aguilar Cecilia , Rocha-Zavaleta Leticia , Blancas Abel 
Published: November 2012

AbstractAgave tequilana fructans are the source of fermentable sugars for the production of tequila. Fructans are processed by acid hydrolysis or by cooking in ovens at high temperature. Enzymatic hydrolysis is considered an alternative for the bioconversion of fructans. We previously described the isolation of Aspergillus niger CH-A-2010, an indigenous strain that produces extracellular inulinases. Here we evaluated the potential application of A. niger CH-A-2010 inulinases for the bioconversion of A. tequilana fructans, and its impact on the production of ethanol. Inulinases were analyzed by Western blotting and thin layer chromatography. Optimal pH and temperature conditions for inulinase activity were determined. The efficiency of A. niger CH-A-2010 inulinases was compared with commercial enzymes and with acid hydrolysis. The hydrolysates obtained were subsequently fermented by Saccharomyces cerevisiae to determine the efficiency of ethanol production. Results indicate that A. niger CH-A-2010 predominantly produces an exo-inulinase activity. Optimal inulinase activity occurred at pH 5.0 and 50 °C. Hydrolysis of raw agave juice by CH-A-2010 inulinases yielded 33.5 g/l reducing sugars, compared with 27.3 g/l by Fructozyme® (Novozymes Corp, Bagsværd, Denmark) and 29.4 g/l by acid hydrolysis. After fermentation of hydrolysates, we observed that the conversion efficiency of sugars into ethanol was 97.5 % of the theoretical ethanol yield for enzymatically degraded agave juice, compared to 83.8 % for acid-hydrolyzed juice. These observations indicate that fructans from raw Agave tequilana juice can be efficiently hydrolyzed by using A. niger CH-A-2010 inulinases, and that this procedure impacts positively on the production of ethanol.
A Phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors
Authors: Marshall John , Hwang Jimmy , Eskens Ferry A. L. M. , Burger Herman , Malik Shakun , Uttenreuther-Fischer Martina , Stopfer Peter , Ould-Kaci Mahmoud , Cohen Roger B. , Lewis Nancy L 
Published: November 2012

Summary
Background A Phase I study to determine the maximum tolerated dose (MTD) and pharmacokinetics of afatinib (BIBW 2992), a novel irreversible ErbB Family Blocker, administered orally once daily in a 3-week-on/1-week-off dosing schedule. Methods Patients with advanced solid tumors received single-agent afatinib at 10, 20, 40, 55 or 65 mg/day. Safety, antitumor activity, pharmacokinetics and pharmacodynamic modulation of biomarkers were assessed. Results: Forty-three patients were enrolled. Dose-limiting toxicities (DLTs) occurred in five patients in the dose escalation phase (1/8 at 40 mg/day; 1/6 at 55 mg/day; 3/6 at 65 mg/day). The MTD was established at 55 mg/day. In the expansion cohort at the MTD, 6 patients experienced a DLT in the first 28-day treatment period. The most frequent DLT was diarrhea. The most common adverse events were diarrhea, rash, nausea, vomiting and fatigue. Overall, the afatinib safety profile in a 3-week-on/1-week-off dose schedule was similar to that of our daily-continuous schedule. Afatinib displayed dose-dependent pharmacokinetics at doses up to and including 55 mg/day, with a terminal half-life suitable for once-daily dosing. Signs of clinical antitumor activity were observed. In biopsies taken from clinically normal forearm skin, afatinib caused a reduced proliferation rate, with a concomitant increase in differentiation of epidermal keratinocytes. Conclusion Afatinib in a 3-week-on/1-week-off schedule showed a good safety profile. The MTD was 55 mg/day, although excess DLTs in the expansion cohort indicated that the 40 mg/day dose would have an acceptable safety profile for future studies. Dose cohorts between 40 and 55 mg/day were not examined in this study.