bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of non‐steroidal anti‐inflammatory drugs for inhibitory effects on the activities of six UDP‐glucuronosyltransferases (UGT1A1, 1A3, 1A4, 1A6, 1A9 and 2B7) using LC‐MS/MS
Authors: Joo Jeongmin , Kim Yang‐Weon , Wu Zhexue , Shin Jung‐Hoon , Lee Boram , Shon Jong Cheol , Lee Eun Young , Phuc Nguyen Minh , Liu Kwang‐Hyeon 
Published: December 2014

AbstractNon‐steroidal anti‐inflammatory drugs (NSAIDs) are used widely to relieve pain and to decrease inflammation. Several clinical studies have reported that NSAIDs inhibit uridine 5′‐diphospho‐glucuronosyltransferase (UGT) enzymes. Therefore, the study evaluated the inhibitory potential of 15 NSAIDs on the activities of six UGT isoforms (i.e. UGT1A1, 1A3, 1A4, 1A6, 1A9 and 2B7) in human liver microsomes (HLMs). Among the 15 NSAIDs tested here, mefenamic acid and diclofenac inhibited all UGTs tested in this study. Piroxicam and niflumic acid inhibited UGT1A9 activity (IC50 = 73.8 μm and 0.38 μm, respectively) and naproxen selectively inhibited UGT2B7 activity (IC50 = 53.1 μm), whereas it did not inhibit the other UGTs tested (IC50 > 200 μm). Diflunisal inhibited the UGT1A1 (IC50 = 33.0 μm) and UGT1A9 (IC50 = 19.4 μm). Acetaminophen, fenoprofen, ibuprofen, ketoprofen, meloxicam, phenylbutazone, salicylic acid and sulindac showed negligible inhibitory effects on the six UGTs (IC50 > 100 μm). These results suggest that some NSAIDs have the potential to inhibit UGTs in vitro. Copyright © 2014 John Wiley & Sons, Ltd.
Chemical synthesis of γ‐secretase activating protein using pseudoglutamines as ligation sites
Authors: Harris Paul W. R. , Squire Chris , Young Paul G. , Brimble Margaret A. 
Published: December 2014

ABSTRACTThe chemical synthesis of analogue of a novel γ‐secretase activating protein, which may play a pivotal role in the formation of amyloid peptides, the precursor to Alzheimer's disease, is described. The linear polypeptide sequence, consisting of 121 amino acids was assembled from four unprotected peptide building blocks using a convergent ligation‐based synthesis. A strategic mutation of three glutamine residues to cysteine enabled the ligations, and the cysteines were subsequently converted to pseudoglutamines, to mimic the native glutamine. The full length unfolded protein was obtained in milligram amounts and was demonstrated to be homogeneous by liquid chromatography and mass spectrometry. © 2014 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 37–45, 2015.
Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer
Authors: Rombouts S J E , Vogel J A , van Santvoort H C , van Lienden K P , van Hillegersberg R , Busch O R C , Besselink M G H , Molenaar I Q 
Published: December 2014

Abstract

Background
Locally advanced pancreatic cancer (LAPC) is associated with a very poor prognosis. Current palliative (radio)chemotherapy provides only a marginal survival benefit of 2–3 months. Several innovative local ablative therapies have been explored as new treatment options. This systematic review aims to provide an overview of the clinical outcomes of these ablative therapies.

Methods
A systematic search in PubMed, Embase and the Cochrane Library was performed to identify clinical studies, published before 1 June 2014, involving ablative therapies in LAPC. Outcomes of interest were safety, survival, quality of life and pain.

Results
After screening 1037 articles, 38 clinical studies involving 1164 patients with LAPC, treated with ablative therapies, were included. These studies concerned radiofrequency ablation (RFA) (7 studies), irreversible electroporation (IRE) (4), stereotactic body radiation therapy (SBRT) (16), high-intensity focused ultrasound (HIFU) (5), iodine-125 (2), iodine-125–cryosurgery (2), photodynamic therapy (1) and microwave ablation (1). All strategies appeared to be feasible and safe. Outcomes for postoperative, procedure-related morbidity and mortality were reported only for RFA (4–22 and 0–11 per cent respectively), IRE (9–15 and 0–4 per cent) and SBRT (0–25 and 0 per cent). Median survival of up to 25·6, 20·2, 24·0 and 12·6 months was reported for RFA, IRE, SBRT and HIFU respectively. Pain relief was demonstrated for RFA, IRE, SBRT and HIFU. Quality-of-life outcomes were reported only for SBRT, and showed promising results.

Conclusion
Ablative therapies in patients with LAPC appear to be feasible and safe.
The Addition of Nitriles to Tetramesityldisilene: A Comparison of the Reactivity between Surface and Molecular Disilenes
Authors: Hardwick Julie A. , Baines Kim M. 
Published: December 2014

AbstractThe addition of acetonitrile, propionitrile, and phenylacetonitrile to tetramesityldisilene (Mes2SiSiMes2) was examined. In general, 1,2,3‐azadisiletines and the tautomeric enamines were formed, although a ketenimine was formed as the major product in the addition of phenylacetonitrile to the disilene. In the presence of LiCl, the mode of addition changed for both acetonitrile and propionitrile: insertion into the α‐CH bond of acetonitrile and/or formation of the formal HCN adduct was observed. Preliminary investigations of the reactivity of the nitrile adducts are also reported. A comparison between the reactivity of nitriles with Mes2SiSiMes2 and the Si(100)‐2×1 surface was made both in terms of the types of adducts formed and their reactivity. Some insights into the surface chemistry are offered.
Marital status and head and neck cancer outcomes
Authors: Inverso Gino , Mahal Brandon A. , Aizer Ayal A. , Donoff R. Bruce , Chau Nicole G. , Haddad Robert I. 
Published: December 2014

BACKGROUNDThe objective of this study was to examine the effects of marital status on stage at presentation, receipt of treatment, and survival in patients with head and neck cancer (HNC).METHODSThe Surveillance, Epidemiology, and End Results database was used to analyze 51,272 patients who were diagnosed with HNC from 2007 to 2010. The impact of marital status on cancer stage at presentation, receipt of definitive treatment, and HNC‐specific mortality (HNCSM) was determined using multivariable logistic and Fine and Gray competing‐risks regression models, as appropriate.RESULTSMarriage had a protective effect against metastatic presentation of oral and laryngeal cancers (oral cancer: adjusted odds ratio [AOR], 0.72; 95% confidence interval [CI], 0.60‐0.87; P < .001; laryngeal cancer: AOR, 0.53; 95% CI, 0.42‐0.67; P < .001) but not against oropharyngeal, hypopharyngeal, or nasopharyngeal cancers. Among patients with nonmetastatic disease, married patients were more likely to receive definitive treatment (overall AOR, 1.77; 95% CI, 1.60‐1.95; P < .001) and had a lower risk of HNCSM (overall adjusted hazard ratio, 0.72; 95% CI, 0.68‐0.77; P < .001); these associations remained significant across all HNC sites.CONCLUSIONSAmong patients with oral and laryngeal cancers, those who are married are less likely to present with metastatic disease. In addition, married patients are more likely to receive definitive treatment and less likely to die from HNC across all HNC sites. This suggests that spousal support may have a role in the surveillance of visual and symptomatic HNC types and leads to higher rates of treatment and better survival across all HNC sites. Cancer 2015;121:1273–1278. © 2014 American Cancer Society.
Phase 2 trial of the cyclin‐dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein‐expressing germ cell tumors
Authors: Vaughn David J. , Hwang Wei‐Ting , Lal Priti , Rosen Mark A. , Gallagher Maryann , O'Dwyer Peter J. 
Published: December 2014

BACKGROUNDAlterations in the retinoblastoma pathway in germ cell tumors (GCTs) have been described. In the phase 1 trials of the selective cyclin‐dependent kinase 4/6 inhibitor palbociclib, 3 patients with unresectable, growing, mature teratoma syndrome achieved prolonged disease stabilization. The authors conducted an open‐label, phase 2 study to determine the efficacy and safety of palbociclib in patients with incurable, refractory, retinoblastoma protein (pRB)‐expressing GCTs.METHODSPatients who had incurable, refractory GCTs that demonstrated pRB expression by immunohistochemistry received oral palbociclib 125 mg daily for 21 days followed by a 7‐day break. The primary endpoint was the 24‐week progression‐free survival (PFS) rate. A 24‐week PFS rate ≥15% was considered promising, and a PFS rate ≤5% was not considered promising.RESULTSThirty patients received treatment, and 29 were evaluable for the primary endpoint. The estimated 24‐week PFS rate was 28% (90% exact confidence interval, 15%‐44%). Patients who had teratoma and teratoma with malignant transformation had significantly better PFS than patients who had nonteratomatous GCTs. Toxicity was manageable and was principally hematologic.CONCLUSIONSTreatment with palbociclib was associated with a favorable 24‐week PFS rate in patients with refractory, pRB‐expressing GCTs. Benefit was mainly observed in patients who had unresectable teratomas and teratomas with malignant transformation. Cancer 2015;121:1463–1468. © 2014 American Cancer Society.
A Visible‐Light Harvesting System for CO2 Reduction Using a RuII–ReI Photocatalyst Adsorbed in Mesoporous Organosilica
Authors: Ueda Yutaro , Takeda Hiroyuki , Yui Tatsuto , Koike Kazuhide , Goto Yasutomo , Inagaki Shinji , Ishitani Osamu 
Published: December 2014

AbstractA photocatalytic system for CO2 reduction exhibiting visible‐light harvesting was developed by preparing a hybrid consisting of a supramolecular metal complex as photocatalyst and periodic mesoporous organosilica (PMO) as light harvester. A RuIIReI binuclear complex (RuRe) with methylphosphonic acid anchor groups was adsorbed on acridone or methylacridone embedded in the walls of PMO mesochannels to yield the hybrid structure. The embedded organic groups absorbed visible light, and the excitation energy was funneled to the Ru units. The energy accumulation was followed by electron transfer and catalytic reduction of CO2 to CO on the Re unit. The light harvesting of these hybrids enhanced the photocatalytic CO evolution rate by a factor of up to ten compared with that of RuRe adsorbed on mesoporous silica without a light harvester.
Barrier Strain and Carbon Incorporation‐Engineered Performance Improvements for AlGaN/GaN High Electron Mobility Transistors**
Authors: Luong Tien Tung , Ho Yen Teng , Tran Binh Tinh , Woong Yuen Yee , Chang Edward Yi 
Published: December 2014

AbstractThe improvements in electrical characteristics of AlGaN/GaN high electron mobility transistors (HEMTs) grown using metal‐organic (MO)CVD by engineering structure, barrier strain, and unintentional carbon incorporation, are demonstrated in this work. Both normal HEMT structure (with a high temperature (HT) AlN buffer) and advanced HEMT structure (with a high‐low‐high temperature (HLHT) AlN buffer, and a HT AlN interlayer (IL)) present a breakdown voltage higher than 200 V, while a much smaller breakdown voltage of 17 V is measured on the conventional structure using a low‐temperature GaN buffer. The HT AlN IL inserted in the middle of the conventional HEMT structure introduces a reduction in the tension of the AlGaN barrier, which results in an improvement of the surface morphology (0.46 nm). As a consequence, the two‐dimensional electron gas (2DEG) mobility increases by remarkable 46% (1900 cm2 V−1 s−1). The HLHT AlN buffer, substituting for the HT AlN buffer, leads to the enhancement of GaN crystalline quality, which contributes to the performance improvement for HEMTs. The advanced HEMT, using both an AlN IL and an HLHT AlN buffer, produces increases in the DC maximum drain current by 35.5% (∼680 A mm−1), and in the transconductance by 15% (114 mS mm−1) in comparison with the normal HEMT with an AlN buffer. The very low leakage current in the advanced HEMTs is caused by optimizing the design of the buffer and modifying growth parameters. Lastly, the reduction of AlGaN barrier tensile strain by inserting the HT AlN IL is promising for an improvement in AlGaN/GaN HEMT reliability.
A low‐complexity resource allocation algorithm in OFDMA‐based cooperative cognitive radio networks
Authors: Tang Yi , Wang Lijie , Zhao Haitao , Wei Jibo 
Published: December 2014

SummaryIn this paper, we propose a low‐complexity resource allocation algorithm for the orthogonal frequency division multiplexing cooperative cognitive radio networks, where multiple primary users (PUs) and multiple secondary users (SUs) coexist. Firstly, we introduce a new concept of ‘efficiency capacity’ to represent the channel conditions of SUs by considering both of the interference caused by the PUs and the channel gains of the SUs with the assist of the relays. Secondly, we allocate the relay, subcarrier and transmission power jointly under the constraint of limiting interference caused to the PUs. Simulation results show that the proposed algorithm can achieve a high data rate with a relative low power level. Copyright © 2014 John Wiley & Sons, Ltd.
An appraisal of how the vitamin A‐redox hypothesis can maintain honesty of carotenoid‐dependent signals
Authors: Simons Mirre J. P. , Groothuis Ton G. G. , Verhulst Simon 
Published: December 2014

AbstractThe vitamin A‐redox hypothesis provides an explanation for honest signaling of phenotypic quality by carotenoid‐dependent traits. A key aspect of the vitamin A‐redox hypothesis, applicable to both yellow and red coloration, is the hypothesized negative feedback of tightly regulated Vitamin A plasma levels on the enzyme responsible for sequestering both Vitamin A and carotenoids from the gut. We performed a meta‐analysis and find that vitamin A levels are positively related to carotenoid plasma levels (r = 0.50, P = 0.0002). On the basis of this finding and further theoretical considerations, we propose that the vitamin A‐redox hypothesis is unlikely to explain carotenoid‐dependent honest signaling.
Bioaccumulation kinetics of the conventional energetics TNT and RDX relative to insensitive munitions constituents DNAN and NTO in Rana pipiens tadpoles
Authors: Lotufo Guilherme R. , Biedenbach James M. , Sims Jerre G. , Chappell Pornsawan , Stanley Jacob K. , Gust Kurt A. 
Published: December 2014

Abstract

The manufacturing of explosives and their loading, assembling, and packing into munitions for use in testing on training sites or battlefields has resulted in contamination of terrestrial and aquatic sites that may pose risk to populations of sensitive species. The bioaccumulative potential of the conventional explosives 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and of the insensitive munitions (i.e., less shock sensitive) compound 2,4-dinitroanisole (DNAN) were assessed using the Northern leopard frog, Rana pipiens. Trinitrotoluene entering the organism was readily biotransformed to aminodinitrotoluenes, whereas no transformation products were measured for RDX or DNAN. Uptake clearance rates were relatively slow and similar among compounds (1.32–2.19 L kg−1 h−1). Upon transfer to uncontaminated water, elimination rate was very fast, resulting in the prediction of fast time to approach steady state (5 h or less) and short elimination half-lives (1.2 h or less). A preliminary bioconcentration factor of 0.25 L kg−1 was determined for the insensitive munitions compound 3-nitro-1,2,4-trizole-5-one (NTO) indicating negligible bioaccumulative potential. Because of the rapid elimination rate for explosives, tadpoles inhabiting contaminated areas are expected to experience harmful effects only if under constant exposure conditions given that body burdens can rapidly depurate preventing tissue concentrations from persisting at levels that may cause detrimental biological effects. Environ Toxicol Chem 2015;34:880–886. © 2014 SETAC
Test Rig for Hybrid System Emulation: New Real‐Time Transient Model Validated in a Wide Operative Range
Authors: Damo U. M. , Ferrari M. L. , Turan A. , Massardo A. F. 
Published: December 2014

AbstractThis paper reports an entirely new simulation tool for a hybrid system emulator facility built by the Thermochemical Power Group (TPG) at the University of Genoa, Italy. This new software was developed with the following targets: real‐time performance, good stability level and high calculation reliability. In details, to obtain real‐time performance a new approach based on 0‐D technique was chosen also for components usually analysed with 1‐D or 2‐D tools (e.g. the recuperator). These are essential key aspects to operate it in hardware‐in‐the‐loop mode or to evaluate predictive results for long transient operations. This work was based on collaboration between the University of Manchester, UK and the University of Genoa, Italy.The activity was carried out with a test rig composed of the following technology: a microturbine package able to produce up to 100 kWe and modified for external connections, external pipes designed for several purposes (by‐pass, measurement or bleed), and a high temperature modular vessel necessary to emulate the dimension of an SOFC stack. The real‐time transient model of this facility was developed inside the Matlab‐Simulink environment with the following modelling approach: a library of components allows to reach a high level of flexibility and an user‐friendly approach. This model includes the machine control system as an essential device to analyse further layouts (new components in the rig) and hardware‐in‐the‐loop operations.The experimental data collected in the laboratory by TPG were used to validate the simulation tool. The results calculated with the model were satisfactory compared with experimental data considering both steady‐state and transient operations. The most important innovative aspects of this work are related to this wide validation range (not only small power steps, but the whole operative range was considered) obtaining real‐time performance and considering microturbine conditions different from standard operations (additional pressure and temperature losses and unusual thermal capacitance). The modelling simplified approach used for such a complex system is an important innovative aspect, because usually the model reliability performance is obtained with more complex (and not real‐time) tools. This work is based on an innovative modelling approach based on 0‐D tools able to operate in real‐time mode (as necessary for hardware‐in‐the‐loop tests) with an accuracy level comparable with more complex and more time consuming software.This validated tool is an important base for future calculations to study innovative hybrid system layouts. For instance, TPG is planning to analyse the option of increasing fuel cell pressure and performance with a booster system (e.g. a turbocharger).
Clinical activity of androgen deprivation therapy in patients with metastatic/relapsed androgen receptor–positive salivary gland cancers
Authors: Locati Laura D. , Perrone Federica , Cortelazzi Barbara , Lo Vullo Salvatore , Bossi Paolo , Dagrada Gianpaolo , Quattrone Pasquale , Bergamini Cristiana , Potepan Paolo , Civelli Enrico , Fallai Carlo , Pilotti Silvana , Licitra Lisa 
Published: December 2014

AbstractBackgroundAndrogen deprivation therapy has some clinical activity in selected salivary gland cancer histotypes, with androgen receptor expression.MethodsWe retrospectively analyzed patients with androgen receptor‐expressing recurrent/metastatic salivary gland cancer, treated with androgen deprivation therapy. Protein expression of androgen receptor and ErbB family members was investigated. Progression‐free survival (PFS) and overall survival (OS) were the main endpoints.ResultsSeventeen patients were identified. No significant toxicities were reported. Overall response rate was 64.7%; 3‐year PFS and 5‐year OS were 11.8% and 19.3%, respectively. Androgen receptor overexpression may be sustained by gain of chromosome X (58%) and TP53 mutation (44%). No association between response to androgen deprivation therapy and epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, HER3 expression, PIK3CA mutations, or phosphatase and tensin homolog (PTEN) deletion was identified.ConclusionWe confirm the activity of androgen deprivation therapy in androgen receptor‐expressing recurrent/metastatic salivary gland cancers. The hypothesis that an androgen receptor increased gene copy number may represent a possible mechanism of primary resistance should be further investigated. © 2015 Wiley Periodicals, Inc. Head Neck 38: 724–731, 2016
Rising prevalence of human papillomavirus–related oropharyngeal cancer in Australia over the last 2 decades
Authors: Hong Angela , Lee C. Soon , Jones Deanna , Veillard Anne‐Sophie , Zhang Mei , Zhang Xiaoying , Smee Robert , Corry June , Porceddu Sandro , Milross Christopher , Elliott Michael , Clark Jonathan , Rose Barbara 
Published: December 2014

AbstractBackgroundThis study provides Australian data on the characteristics of human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) over the last 2 decades.MethodsThe HPV status of 515 patients with oropharyngeal SCC diagnosed between 1987 and 2010 was determined by HPV E6‐targeted multiplex real time polymerase chain reaction assay (PCR) and p16 immunohistochemistry.ResultsThe HPV positivity rate increased from 20.2% (1987–1995) to 63.5% (2006–2010). Among HPV‐positive oropharyngeal SCC over the study period, the median age increased from 55.4 years to 59.8 years (p = .004) and there was a trend of an increasing proportion of never smokers (19.2% to 34.0%). The use of radiation therapy (RT) in patients with HPV‐positive oropharyngeal cancer increased from 26.9% to 68.1% (p = .007) and we also observed a trend of improved outcomes.ConclusionOur data show a rising prevalence of HPV‐positive oropharyngeal SCC in Australia over the last 2 decades. These patients with HPV‐positive oropharyngeal SCC are now presenting at an older age and about one third have never smoked. © 2015 Wiley Periodicals, Inc. Head Neck 38: 743–750, 2016
Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers
Authors: Hussain Timon , Savariar Elamprakash N. , Diaz–Perez Julio A. , Messer Karen , Pu Minya , Tsien Roger Y. , Nguyen Quyen T. 
Published: December 2014

AbstractBackgroundWe evaluated the use of intraoperative fluorescence guidance by enzymatically cleavable ratiometric activatable cell‐penetrating peptide (RACPPPLGC(Me)AG) containing Cy5 as a fluorescent donor and Cy7 as a fluorescent acceptor for salivary gland cancer surgery in a mouse model.MethodsSurgical resection of small parotid gland cancers in mice was performed with fluorescence guidance or white light (WL) imaging alone. Tumor identification accuracy, operating time, and tumor‐free survival were compared.ResultsRACPP guidance aided tumor detection (positive histology in 90% [27/30] vs 48% [15/31] for WL; p < .001). An approximate 25% ratiometric signal increase as the threshold to distinguish between tumor and adjacent tissue, yielded >90% detection sensitivity and specificity. Operating time was reduced by 54% (p < .001), and tumor‐free survival was increased with RACPP guidance (p = .025).ConclusionRACPP provides real‐time intraoperative guidance leading to improved survival. Ratiometric signal thresholds can be set according to desired detection accuracy levels for future RACPP applications. © 2015 Wiley Periodicals, Inc. Head Neck 38: 715–723, 2016