bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cochlear Implantation and Single-sided Deafness: A Systematic Review of the Literature
Authors: Cabral Junior Francisco , Pinna Mariana , Alves Ricardo , Malerbi Andrea , Bento Ricardo 
Published: July 2015

Introduction Current data show that binaural hearing is superior to unilateral hearing, specifically in the understanding of speech in noisy environments. Furthermore, unilateral hearing reduce onés ability to localize sound.
Objectives This study provides a systematic review of recent studies to evaluate the outcomes of cochlear implantation in patients with single-sided deafness (SSD) with regards to speech discrimination, sound localization and tinnitus suppression.
Data Synthesis We performed a search in the PubMed, Cochrane Library and Lilacs databases to assess studies related to cochlear implantation in patients with unilateral deafness. After critical appraisal, eleven studies were selected for data extraction and analysis of demographic, study design and outcome data.
Conclusion Although some studies have shown encouraging results on cochlear implantation and SSD, all fail to provide a high level of evidence. Larger studies are necessary to define the tangible benefits of cochlear implantation in patients with SSD.
Canonical, stable, general mapping using context schemes
Authors: Novak Adam M. , Rosen Yohei , Haussler David , Paten Benedict 
Published: July 2015

Abstract
Motivation: Sequence mapping is the cornerstone of modern genomics. However, most existing sequence mapping algorithms are insufficiently general.
Results: We introduce context schemes: a method that allows the unambiguous recognition of a reference base in a query sequence by testing the query for substrings from an algorithmically defined set. Context schemes only map when there is a unique best mapping, and define this criterion uniformly for all reference bases. Mappings under context schemes can also be made stable, so that extension of the query string (e.g. by increasing read length) will not alter the mapping of previously mapped positions. Context schemes are general in several senses. They natively support the detection of arbitrary complex, novel rearrangements relative to the reference. They can scale over orders of magnitude in query sequence length. Finally, they are trivially extensible to more complex reference structures, such as graphs, that incorporate additional variation. We demonstrate empirically the existence of high-performance context schemes, and present efficient context scheme mapping algorithms.
Availability and implementation: The software test framework created for this study is available from https://registry.hub.docker.com/u/adamnovak/sequence-graphs/.
Contact: anovak@soe.ucsc.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Designing alternative splicing RNA-seq studies. Beyond generic guidelines
Authors: Stephan-Otto Attolini Camille , Peña Victor , Rossell David 
Published: July 2015

AbstractMotivation: Designing an RNA-seq study depends critically on its specific goals, technology and underlying biology, which renders general guidelines inadequate. We propose a Bayesian framework to customize experiments so that goals can be attained and resources are not wasted, with a focus on alternative splicing.Results: We studied how read length, sequencing depth, library preparation and the number of replicates affects cost-effectiveness of single-sample and group comparison studies. Optimal settings varied strongly according to the target organism or tissue (potential 50–500% cost cuts) and, interestingly, short reads outperformed long reads for standard analyses. Our framework learns key characteristics for study design from the data, and predicts if and how to continue experimentation. These predictions matched several follow-up experimental datasets that were used for validation. We provide default pipelines, but the framework can be combined with other data analysis methods and can help assess their relative merits.Availability and implementation: casper package at www.bioconductor.org/packages/release/bioc/html/casper.html, Supplementary Manual by typing casperDesign() at the R prompt.Contact: rosselldavid@gmail.comSupplementary information: Supplementary data are available at Bioinformatics online.
Friction laws from dimensional-analysis point of view
Authors: Hatano Takahiro 
Published: July 2015

Abstract
Friction laws, which are a key to the understanding of the diversity of earthquakes, are considered theoretically. Using dimensional analysis, the logarithmic dependence of the friction coefficient on the slip velocity and the state variable is derived without any knowledge of the underlying physical processes on the frictional surface. This is based on a simple assumption that the friction coefficient is expressed as the difference from a reference state. Therefore, the functional form of the rate and state dependent friction law itself does not necessarily mean that thermal activation processes dominate friction. It is also shown that if there are two (or more) state variables having the same dimension, we need not assume the logarithmic dependence on the state variables.
Sterile Corneal Infiltrates Secondary to Psoriasis Exacerbations: Topical Tacrolimus as an Alternative Treatment Option
Authors: Gonzalez-Andrades Miguel , Arias-Santiago Salvador , García-Serrano José Luis , González Gallardo María del Carmen , McAlinden Colm 
Published: July 2015

Introduction:
Psoriasis is a common chronic inflammatory skin disease. Ocular manifestations, which occur in 10% to 20% of cases of psoriasis, are usually bilateral and often present during an exacerbation of the psoriasis. Serious corneal involvement is rare but can be devastating.

Case Report:
Two cases of sterile corneal infiltrates secondary to an exacerbation of psoriasis are presented. Treatment involved the use of 0.02% topical tacrolimus ointment, which resulted in resolution of the symptoms and infiltrates.

Discussion and Conclusion:
Topical tacrolimus may be considered as an alternative treatment option to corticosteroids in sterile corneal infiltrates.
FTO Polymorphism rs9939609 Contributes to Weight Changes in Children With Celiac Disease on Gluten‐Free Diet
Authors: Grandone Anna , Marzuillo Pierluigi , Cirillo Grazia , Squitieri Rosanna , Tolone Salvatore , Miraglia del Giudice Emanuele , Perrone Laura , Tolone Carlo 
Published: July 2015

ABSTRACTObjectives:Studies of adults and children with celiac disease have reported an increased risk of overweight during gluten‐free diet (GFD). The fat mass and obesity‐associated gene (FTO) variant rs9939609 has been associated with increased risk of developing obesity in children and adults.Methods:In our study, we analyzed the effect of this variant on weight gain in a cohort of 280 children with celiac disease on GFD.Results:We found that after a mean follow‐up time of 3.0 years on GFD, FTO polymorphism influenced significantly the mean change in body mass index z score (P = 0.01).Conclusions:We conclude that the FTO gene contributes to determine weight changes in children with celiac disease on GFD.
Implementation of an Advanced Nursing Directive for Children With Right Lower Quadrant Pain
Authors: Thompson Graham C. , Kwong Simon , Bobrovitz Niklas , Yang Stephanie , Pols Erin Kate , Stang Antonia S. , Eccles Robin C. , Kazoleas Veronica 
Published: July 2015

Objectives
Advanced nursing directives (ANDs) empower nursing staff to provide advanced levels of care before physician assessment. The objectives of this study were (1) to determine whether an AND for right lower quadrant (RLQ) pain could identify children who required any further investigation to diagnose appendicitis and (2) to determine whether children meeting AND criteria had better emergency department (ED) flow metrics compared with those who did not meet the criteria.

Methods
Health records of children aged 3 to 17 years presenting to the ED with abdominal pain who were managed using the departmental AND for RLQ pain were reviewed. Primary outcomes included (1) the proportion of patients requiring further investigation to diagnose appendicitis and (2) the time interval from triage to blood draw. Secondary outcomes included additional ED flow metrics, perforation rate, and negative appendectomy rate.

Results
An AND was completed for 210 children. Those who met the AND criteria were more likely to undergo further investigation to rule out appendicitis than those who did not meet the criteria (92/137 [67.2%] vs 32/73 [43.8%]; odds ratio [OR], 2.62; 95% confidence interval [CI], 1.40–4.90). Time to blood draw was significantly lower for those children meeting the AND criteria (74 vs 162 minutes, P < 0.001) as was time to hospital admission (271 vs 395 minutes, P = 0.008) and appendectomy (498 vs 602 minutes, P = 0.015). The negative appendectomy rate was 8.6% (5/58) for children meeting the AND criteria and 9.1% (2/22) for those not meeting the criteria (OR, 0.94; 95% CI, 0.14–10.67); the perforation rate was 29.3% (17/58) and 4.5% (1/22), respectively (OR, 8.17; 95% CI, 1.17–380.86).

Conclusions
Children presenting to the ED with RLQ pain who meet the AND criteria are more likely to require further investigation to rule out appendicitis and have better department flow metrics than those who do not meet the criteria. Our results provide further evidence of the utility of ANDs in the ED.
Circlator: automated circularization of genome assemblies using long sequencing reads
Authors: Hunt Martin , De Silva Nishadi , Otto Thomas D , Parkhill Julian , Keane Jacqueline A , Harris Simon R 
Published: July 2015

AbstractThe assembly of DNA sequence data into finished genomes is undergoing a renais-sance thanks to emerging technologies producing reads of tens of kilobases. Assembling complete bacterial and small eukaryotic genomes is now possible, but the final step of circularizing sequences remains unsolved. Here we present Circlator, the first tool to automate assembly circularization and produce accurate linear rep-resentations of circular sequences. Using Pacific Biosciences and Oxford Nanopore data, Circlator correctly circularized 26 of 27 circularizable sequences, comprising 11 chromosomes and 12 plasmids from bacteria, the apicoplast and mitochondrion ofPlasmodium falciparumand a human mitochondrion. Circlator is available athttp://sanger-pathogens.github.io/circlator/.
Construction of China’s nominal energy condition index
Authors: Bai Caiquan , He Yiqing , Zhou Decai , Zhang Yi , Jiang Zhengyi 
Published: July 2015

PurposeThe paper aims to know about energy condition’s impacts on inflation comprehensively.Design/methodology/approachThis paper constructs China’s energy condition index (ECI) by bringing in three variables (China’s energy price, consumption and production) based on the financial condition index.FindingsThe result of empirical analysis shows that the index can predict China’s inflation well.Originality/valueChina’s ECI can predict China’s inflation well.
Energy consumption and growth in South Asia: evidence from a panel error correction model
Authors: Vidyarthi Harishankar 
Published: July 2015

Purpose
The purpose of the paper is to empirically examine the relationship between energy consumption and economic growth for a panel of five South Asian economies, namely, India, Pakistan, Bangladesh, Sri Lanka and Nepal over the period from 1971 to 2010 within a multivariate framework.

Design/methodology/approach
The study uses Pedroni cointegration and Granger causality test based on panel vector error correction model to examine long-run equilibrium relationship and direction of causation in the short and long run between energy consumption and economic growth using energy inclusive Cobb–Douglas production function for a panel of five South Asia countries, namely India, Pakistan, Bangladesh, Sri Lanka and Nepal.

Findings
Pedroni’s panel cointegration test indicates the long-run equilibrium relationship between economic growth per capita, energy consumption per capita and real gross fixed capital formation per capita for panel. Further, 1 per cent increase in energy consumption per capita increases the gross domestic product (GDP) per capita by 0.8424 per cent for the panel. Causality results suggest bidirectional causality between energy consumption per capita, gross fixed capital formation per capita and GDP per capita in the long run and unidirectional causality running from energy consumption per capita and gross fixed capital formation per capita to GDP per capita in the short run.

Practical implications
These South Asian countries should implement an expansionary energy policies through improving the energy infrastructure, energy efficiency measures and exploiting massive renewables’ availability for low-cost, affordable clean energy access for all, especially in the yet unserved rural and remote areas for further stimulating economic growth.

Originality/value
Implementing energy efficiency measures and massive renewables development (wind, solar and hydropower) may help the affordable and clean energy access and reducing fossils fuel dependence and its associated greenhouse emissions in South Asia.
Patient involvement in Danish health care
Authors: Vrangbaek Karsten 
Published: July 2015

Purpose– The purpose of this paper is to investigate different types of patient involvement in Denmark, and to discuss the potential implications of pursuing several strategies for patient involvement simultaneously.Design/methodology/approach– The paper presents a preliminary framework for analysis of patient involvement in health care. This framework is used to analyze key governance features of patient involvement in Denmark based on previous research papers and reports describing patient involvement in Danish health care.Findings– Patient involvement is important in Denmark at the rhetorical level, and many policies and initiatives have been introduced. All three governance forms (voice, choice and co-production) are used. However, there are important barriers and limitations in translating the rhetoric into practice, and potential synergy and negative synergy effects can be identified when pursuing the strategies at the same time.Research limitations/implications– Because of the chosen research approach, the research results may lack generalizability. Therefore, researchers are encouraged to test the proposed framework further.Practical implications– The paper includes implications for the development of patient involvement in health care.Originality/value– This paper fulfills a need to study different types of patient involvement and to develop a theoretical framework for characterizing and analyzing such involvement strategies.
Users’ involvement in the Italian NHS: the role of associations and self-help groups
Authors: Pavolini Emmanuele , Spina Elena 
Published: July 2015

Purpose
– The purpose of the paper is to show the importance of considering patients’ and citizens’ associations for understanding users’ involvement in health care systems.

Design/methodology/approach
– The paper is based on both qualitative and quantitative data on Italy drawn from various sources (national statistics, own survey data, qualitative interviews).

Findings
– Although the paper avoids an excessively positive view of the success and frequency of collective patients’ participation, it nevertheless shows that the Italian National Health Care System (NHS) is undergoing important changes in this regard. Voice and co-production among patients, health care services and professionals have become more common and important also because of forms of collective action. Professionals themselves often belong to or promote such associations and groups. The Italian case also shows that voice and co-production tend frequently to merge into a single complex strategy where patients’ requests go along with their direct involvement in health care provision.

Social implications
– The study provides useful information for policy makers considering the implementation of policies that promote collective action in order to increase an active users’ participation in health care.

Originality/value
– This is one of the limited number of Italian studies which investigates users’ involvement in the NHS and collective action, thus adding knowledge to the limited research in this field.
User involvement in Slovenian healthcare
Authors: Kavcic Matic , Pahor Majda , Domajnko Barbara 
Published: July 2015

Purpose– The purpose of this paper is to report on current developments in user involvement in healthcare in Slovenia and to explore the issue from the macro-, mezzo- and micro-levels.Design/methodology/approach– User involvement is first contextualised within history of the organisation of healthcare system, from its socialist past through to its post-transitional developments. Second, user involvement is tracked through an analysis of healthcare policies and legislation as well as at its institutional and organisational levels. Finally, user involvement practices are illustrated from the perspective of individual patients. A descriptive and exploratory case study design was employed, including a literature review, document analysis and qualitative thematic analysis of nine in-depth and four semi-structured interviews.Findings– The findings reveal a complex and at times ambivalent picture in which user involvement is still not firmly embedded into the healthcare system, despite being generally accepted.Originality/value– No systematic qualitative research of patient involvement in Slovenia has previously been published. This research will establish a basis for further investigations of the topic.
Buzzing with disclosure of social shopping rewards
Authors: Coker Kesha K. , Smith Denise S , Altobello Suzanne A 
Published: July 2015

Purpose
– The purpose of this paper is to examine the dilemma that is based on a decision to disclose or not to disclose social shopping rewards (SSRs), in an effort to enhance the effectiveness of social shopping. To protect consumers and guide marketers, emergent forms of online commerce on social media platforms warrant closer examination. One such form is social shopping, which combines social media and online shopping. To motivate word of mouth (WOM) through social signs of approval or endorsement of brands, marketers have typically relied on social shopping rewards (SSRs). It is not typical, however, for the reason behind the social endorsement to be disclosed, leaving the branded message open to multiple interpretations.

Design/methodology/approach
– The dilemma of SSR disclosures is presented in a marketing and public policy analysis, drawing from findings from the WOM literature on disclosure, incentives, source credibility and on social media Disclosure Guidelines by the Federal Trade Commission (FTC) and Word of Mouth Marketing Association (WOMMA). Based on this analysis and on an extension of the Dual Credibility Model, a conceptual model is proposed that shows how disclosure works through source credibility to produce positive social shopping outcomes.

Findings
– In addition to the conceptual model, recommendations are made for marketing research, practice and public policy. Of significance are proposed SSR Disclosure Guidelines that extend FTC and WOMMA guidelines for best practices in disclosures in social media.

Originality/value
– This paper represents pioneering research on the disclosure of SSRs.
Making use of elephants: lived experience and organisations
Authors: Paynter Sarah , Rivers Christine 
Published: July 2015

Purpose
– The purpose of this paper is to examine the surrounding attitudes, culture and workplace environment in which Oxleas NHS Foundation trust developed a network for staff with lived experience of mental ill health.

Design/methodology/approach
– Sarah Paynter completed an interview talking about her experiences with a peer, which was recorded, then the authors picked out relevant themes from this which are grounded in lived experience. The paper examines the theme of lived experience in the workplace in more depth, from a personal perspective (Sarah) and from an organisational perspective (Christine).

Findings
– There is a lack of dialogue about staff lived experience of mental ill health within the workplace. There are compelling reasons from both the perspective of the organisation and staff with lived experience for setting up a lived experience staff network. The authors note that increased dialogue and visibility has added value on both sides.

Originality/value
– This is a relatively new initiative in the NHS, and particularly in mental health trusts. The authors speak from their experiences in Oxleas NHS Foundation Trust. This is of value to organisations looking to start dialogue and therefore improve the experiences of staff and the quality of the organisation.
Complicating Symmetric Peripheral Gangrene after Dopamine Therapy to Patients with Septic Shock
Authors: Dong Juan , Zhang Lingli , Rao Guangxun , Zhao Xiaohong 
Published: July 2015

AbstractDopamine is commonly used as a first‐line agent in the treatment of patients with septic shock. The use of dopamine rarely causes symmetric peripheral dry gangrene. If the symmetric peripheral dry gangrene occurs in the patient after dopamine injection, it easily leads to disagreement between doctors and patients. A 60‐year‐old woman who had sudden septic shock was sent to intensive care unit (ICU). She was received dopamine injection according to the routine during treatment. Over the next 3 months, her limbs developed to dry gangrene and required amputation. The result shows that the occurrence of dry gangrene could only be associated with the long‐term excessive use of dopamine according to the medical records. Although dopamine is a conventional drug for the treatment of septic shock, the forensic workers and clinicians must realize that vasopressors such as dopamine have been implicated directly or as a contributory cause in dry gangrene cases.
Severe Mental Illness, Somatic Delusions, and Attempted Mass Murder
Authors: Sarteschi Christine M. 
Published: July 2015

AbstractA case of an attempted mass shooting at a large psychiatric hospital in the United States by a 30‐year‐old male with severe mental illness, somatic delusions, and exceptional access to healthcare professionals is reported. Six persons were shot, one died at the scene, and the shooter was then killed by the police. Data were gathered from court documents and media accounts. An analysis of the shooter's psychiatric history, his interactions with healthcare professionals, and communications prior to the shooting suggest a rare form of mass murder, a random attack by a documented psychotic and delusional individual suffering with somatic delusions. Despite his being psychotic, the killer planned the attack and made a direct threat 1 month prior to the shootings. This case highlights problems with the healthcare system, indicating that it might be ill equipped to appropriately deal with severe mental illness.