bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Solving Tension”: coping among Bhutanese refugees in Nepal
Authors: Chase Liana E. , Welton‐Mitchell Courtney , Bhattarai Shaligram 
Published: August 2013

PurposeThe Bhutanese refugee camps of eastern Nepal are home to a mass resettlement operation; over half the population has been relocated within the past five years. While recent research suggests Bhutanese refugees are experiencing degradation of social networks and rising suicide rates, little is known about ethnocultural pathways to coping and resilience in this population.Design/methodology/approachA common coping measure (Brief COPE) was adapted to the linguistic and cultural context of the refugee camps and administered to a representative sample of 193 Bhutanese refugees as part of a broader ten‐month ethnographic study of resilience.FindingsActive coping, planning, and positive reframing were the most frequently utilized strategies, followed by acceptance, religion, and seeking emotional support. Exploratory factor analysis resulted in five factors: humor, denial, behavioral disengagement; positive reframing, planning, active coping; emotional support, instrumental support; interpersonal (a new sub‐scale), acceptance, self‐blame; and venting, religion.Research implicationsData support the relevance of some dimensions of coping while revealing particularities of this population.Practical implicationsFindings can inform future research and intervention efforts aimed at reducing suicide and promoting mental health across the Bhutanese refugee diaspora.Originality/valueThis is the first mixed‐methods study of coping in the Bhutanese refugee camp population since the start of a mass resettlement exercise. Qualitative data and ethnography were used to illuminate measured trends in local coping behavior.
Key success factor analysis for e‐SCM project implementation and a case study in semiconductor manufacturers
Authors: Hwang Bang‐Ning , Lu Ta‐ping 
Published: August 2013

PurposeThe semiconductor market exceeded US$250 billion worldwide in 2010 and has had a double‐digit compound annual growth rate (CAGR) in the last 20 years. As it is located far upstream of the electronic product market, the semiconductor industry has suffered severely from the “bullwhip” effect. Therefore, effective e‐based supply chain management (e‐SCM) has become imperative for the efficient operation of semiconductor manufacturing (SM) companies. The purpose of this research is to define and analyze the key success factors (KSF) for e‐SCM system implementation in the semiconductor industry.Design/methodology/approachA hierarchy of KSFs is defined first by a combination of a literature review and a focus group discussion with experts who successfully implemented an inter‐organizational e‐SCM project. Fuzzy analytic hierarchy process (FAHP) is then employed to rank the importance of these identified KSFs. To confirm the research result and further explore the managerial implications, a second in‐depth interview with the e‐SCM project executives is conducted.FindingsThe KSF hierarchy is constructed with two levels: a top‐level consisting of four dimensions and a detailed‐level consisting of 15 individual factors. The research shows that, in the top‐level, strategy is the most critically successful dimension followed by process, organization, and technical; whereas in the detailed‐level, the top management commitment, clear project goal and business requirements, and business process re‐engineering are the top three critical successful factors.Research limitations/implicationsResearch surveys and interviews were conducted with two leading companies: Taiwan Semiconductor Manufacturing Company (TSMC) and ASE; they are the largest front‐end and back‐end SM companies in the world, respectively. Although the data collected was primarily based on the experience of one successful e‐SCM project, the significant roles of these two companies and compelling contribution made by the e‐SCM project leading to the research resulted in valuable guidelines for the companies in the semiconductor industry and a useful reference for companies in other manufacturing industries.Originality/valuee‐SCM system has a high failure rate and there is little literature discussing the KSF of e‐SCM implementation from a holistic view for certain industries. This paper not only provides a structured and comprehensive list of KSFs but also illustrates the application of the most critical factors by examples. In addition to the contributions made to industries, the research results can also serve as a foundation for related academic research when comparing the KSFs of implementing e‐SCM by different industries.
Implications of Yuan/dollar exchange rate for trade
Authors: Hilland Amy , Devadoss Stephen 
Published: August 2013

PurposeThough an undervalued Yuan is not the only factor that contributes to the US bilateral trade deficit with China, it is widely accepted as being one of the leading factors. The heightened debate over the value of the Yuan may lead to “beggar thy neighbour” retaliation. The purpose of this paper is to provide a historical review of the Y/$ exchange rate movements, review the US congressional bills to revalue the Y/$ exchange rate and Chinese Government's reactions, presents a conceptual analysis of the effect of the undervalued Yuan on trade between China, the USA, and competitors, and discuss the arguments for and against revaluation of the Yuan.Design/methodology/approachConceptual analysis graphically illustrates how the undervalued Yuan affects world trade and shows the benefits and losses for various countries.FindingsThough an undervalued Yuan is not the only factor that contributes to the US bilateral trade deficit with China, it is widely accepted as being one of the leading factors. Due to its effects on production, consumption, and trade, a solution is needed. Although measuring the exact misalignment of the Chinese currency has led to various results, it is generally agreed that the Yuan is undervalued, and the US Congress has been persistent in introducing various bills to tackle the problems arising from the undervalued Yuan. Arguments for and against revaluation has heightened debate which may lead to “beggar thy neighbour” retaliation.Originality/valueThis paper outlines very timely and pretentious trade issues between China and the USA and contributes to the area of research of exchange rate effects on international trade.
Advertising to Chinese youth: a study of public service ads in Hong Kong
Authors: Chan Kara , Chang Hao‐Chieh 
Published: August 2013

PurposeHong Kong youth's general attitudes toward government publicity were studied and their responses to two public service advertisements promoting green lifestyles were measured. The paper aims to discuss these issues.Design/methodology/approachThirty‐four Chinese youths in Hong Kong aged 17 to 22 were questioned about their understanding of and attitudes toward public service advertising in face‐to‐face interviews. Their opinions of two government television ads promoting “green living” were then solicited.FindingsThe interviewees described government publicity in general as credible and practical. Some liked the green living ads for their creativity but others disliked them as boring, unrealistic, irrelevant and uninformative. Recommendations are presented for designing public service campaigns that target youth.Research limitations/implicationsThe results were based on a small convenience sample. More than one interviewer participated, so the results were subject to differences in interviewing techniques.Practical implicationsThe study developed useful information for those organizing public service ad campaigns, especially campaigns aimed at Chinese youth.Originality/valueThis has been the first study to measure youth's attitudes toward public service ad campaigns in the Hong Kong context.
Identification of human leucocyte antigen (HLA)‐A*0201‐restricted cytotoxic T lymphocyte epitopes derived from HLA‐DOβ as a novel target for multiple myeloma
Authors: Kang Yoon Joong , Zeng Wanyong , Song Weihua , Reinhold Bruce , Choi Jaewon , Brusic Vladimir , Yamashita Takuto , Munshi Aditya , Li Cheng , Minvielle Stephane , Anderson Kenneth C. , Munshi Nikhil , Reinherz Ellis L. , Sasada Tetsuro 
Published: August 2013

SummaryDespite the recent development of effective therapeutic agents against multiple myeloma (MM), new therapeutic approaches, including immunotherapies, remain to be developed. Here we identified novel human leucocyte antigen (HLA)‐A*0201 (HLA‐A2)‐restricted cytotoxic T lymphocyte (CTL) epitopes from a B cell specific molecule HLA‐DOβ (DOB) as a potential target for MM. By DNA microarray analysis, the HLA‐DOB expression in MM cells was significantly higher than that in normal plasma cells. Twenty‐five peptides were predicted to bind to HLA‐A2 from the amino acid sequence of HLA‐DOB. When screened for the immunogenicity in HLA‐A2‐transgenic mice immunized with HLA‐DOB cDNA, 4 peptides were substantially immunogenic. By mass spectrometry analysis of peptides eluted from HLA‐A2‐immunoprecipitates of MM cell lines, only two epitopes, HLA‐DOB232–240 (FLLGLIFLL) and HLA‐DOB185–193 (VMLEMTPEL), were confirmed for their physical presence on cell surface. When healthy donor blood was repeatedly stimulated in vitro with these two peptides and assessed by antigen‐specific γ‐interferon secretion, HLA‐DOB232–240 was more immunogenic than HLA‐DOB185–193. Additionally, the HLA‐DOB232–240‐specific CTLs, but not the HLA‐DOB185–193‐specific CTLs, displayed an major histocompatibility complex class I‐restricted reactivity against MM cell lines expressing both HLA‐A2 and HLA‐DOB. Taken together, based on the physical presence on tumour cell surface and high immunogenicity, HLA‐DOB232–240 might be useful for developing a novel immunotherapy against MM.
Genetic and environmental factors underlying the rapid changes in epidemiological and clinical features of multiple sclerosis and neuromyelitis optica in Japanese
Authors: Kira Jun‐ichi 
Published: August 2013

AbstractThe discovery of a specific biomarker for neuromyelitis optica (NMO), NMO‐immunoglobulin G (IgG)/anti‐aquaporin‐4 (AQP4) antibody, requires us to take it into account when interpreting epidemiological findings on multiple sclerosis (MS). Recent genetic studies showed that HLA‐DRB1*0405 is the most common susceptibility allele for non‐NMO MS in Japanese, and that DRB1*0405 carriers comprise >40% of all Japanese MS patients. Thus, idiopathic central nervous system demyelinating disease in Japanese can be subclassified into DRB1*0405‐positive and ‐negative MS, and anti‐AQP4 antibody‐positive and ‐negative NMO. HLA‐DRB1*0405‐positive MS patients show younger age at onset, fewer brain lesions and a slower progression. The recent increase in the numbers of MS patients in this subgroup could explain the decrease in age at onset, as shown by the fourth nationwide survey in Japanese MS patients. Among HLA‐DRB1*0405‐negative MS patients, DRB1*1501 is a risk factor for MS, and DRB1*1501 carriers have high frequencies of brain lesions fulfilling the Barkhof criteria and cerebrospinal fluid IgG abnormalities. HLA‐DRB1*0405‐negative MS patients have higher frequencies of Epstein–Barr virus infection, but a lower frequency of Helicobacter pylori infection, which reflects improved sanitation in childhood. Anti‐AQP4 antibody‐positive NMO is associated with H. pylori and Chlamydia pneumoniae infections. The effects of improved sanitation on this subgroup might explain the decrease in incidence of opticospinal MS with longitudinally extensive spinal cord lesions, regarded as the same disease as NMO, as suggested by the fourth nationwide survey. Therefore, changes in environmental factors could have differentially influenced susceptibility to each disease subtype in Japanese.
Reducing youth violence related to student parties: Findings from a community intervention project in Stockholm
Authors: Ramstedt Mats , Leifman Håkan , Müller Daniel , Sundin Erica , Norström Thor 
Published: August 2013

AbstractBackgroundDuring the spring of 2007, the police reported a marked increase in violence and binge drinking related to high school student graduation parties on weekday nights at restaurants in Stockholm city. This spurred a multi‐component community intervention project to reduce these problems.AimsThis study aims to evaluate the impact of the intervention on youth‐related violence on weekday nights in 2008–2010.Design and MethodThe outcome measure entailed the number of violence‐related emergency room visits on weekday nights (10:00 pm–6:00 am) by adolescents aged 18–20 years. The study period was 1 April–31 May, which is when most student graduation parties took place. The data covered the years 2005–2010, with three data points before the intervention, and three after the intervention was introduced. Because the intervention was expected to apply to weekdays only, the control series involved a corresponding indicator pertaining to weekend nights (10:00 pm–6:00 am). The intervention effect was assessed by means of difference‐in‐differences estimation.ResultsThe estimated intervention effect according to the difference‐in‐differences estimation models was a statistically significant 23% reduction of violence among young people.Discussion and ConclusionThis type of intervention is a promising measure of preventing youth violence and deserves to be continued. Such continuation would also provide additional data required for a more conclusive assessment.[Ramstedt M, Leifman H, Müller D, Sundin E, Norström T. Reducing youth violence related to student parties: Findings from a community intervention project in Stockholm. Drug Alcohol Rev 2013;32:561–565]
Nitrate‐Potentiated Head‐Up Tilt Testing (HUT) Has a Low Diagnostic Yield in Patients with Likely Vasovagal Syncope
Authors: PETIX NUNZIA R. , DEL ROSSO ATTILIO , FURLAN RAFFAELLO , GUARNACCIA VINCENZO , ZIPOLI ANDREA 
Published: August 2013

BackgroundVasovagal syncope (VVS) is characterized by a wide spectrum of clinical presentations, but the relationship between clinical presentation and response to head‐up tilt testing (HUT) has not yet been evaluated in detail. The aim of this study was to assess the relationship between the clinical presentation of VVS and HUT and clinical outcome at long‐term follow‐up.MethodsOut of 671 consecutive subjects undergoing nitroglycerin‐potentiated HUT for suspected VVS, 369 patients with normal electrocardiogram and no structural heart disease were included in our study.ResultsA history suggestive of typical or atypical VVS was obtained in 198 and 171 patients, respectively. The positivity rate of HUT was 65% and 36% in patients with established and likely VVS, respectively (P < 0.0001). In patients with established VVS, a time interval of ≤28 days between the last syncope and HUT was the only independent predictor of a positive test. In patients with likely VVS, no variable was predictive of a positive HUT. At a mean follow‐up of 43 ± 27 months, the rate of adverse events (all‐cause mortality, syncope recurrence, and major diagnostic and/or therapeutic procedures) was similar in patients of both groups, independent of HUT results.ConclusionIn patients with likely VVS, HUT has a low‐diagnostic yield and may be inadequate to establish a reliable diagnosis. Similar long‐term outcomes were observed in patients with positive or negative test results, suggesting that HUT is of limited value in the management of patients with suspected neurally mediated syncope.
Complete Nucleotide Sequence of Encephalomyocarditis Virus Isolated from South China Tigers in China
Authors: Liu Huimin , Yan Qi , He Hongxuan 
Published: August 2013

ABSTRACT
A strain of encephalomyocarditis virus (EMCV), strain FJ13, has been isolated from South China tigers in China, and its complete genome has been sequenced and analyzed. Phylogenetic analysis suggests that FJ13 belongs to the EMCV-1 serotype, and it is highly prevalent in China.
AMG 900, a Small-Molecule Inhibitor of Aurora Kinases, Potentiates the Activity of Microtubule-Targeting Agents in Human Metastatic Breast Cancer Models
Authors: Bush Tammy L. , Payton Marc , Heller Scott , Chung Grace , Hanestad Kelly , Rottman James B. , Loberg Robert , Friberg Gregory , Kendall Richard L. , Saffran Douglas , Radinsky Robert 
Published: August 2013

AbstractBreast cancer is the most prevalent malignancy affecting women and ranks second in cancer-related deaths, in which death occurs primarily from metastatic disease. Triple-negative breast cancer (TNBC) is a more aggressive and metastatic subtype of breast cancer that is initially responsive to treatment of microtubule-targeting agents (MTA) such as taxanes. Recently, we reported the characterization of AMG 900, an orally bioavailable, potent, and highly selective pan-Aurora kinase inhibitor that is active in multidrug-resistant cell lines. In this report, we investigate the activity of AMG 900 alone and in combination with two distinct classes of MTAs (taxanes and epothilones) in multidrug-resistant TNBC cell lines and xenografts. In TNBC cells, AMG 900 inhibited phosphorylation of histone H3 on Ser10, a proximal substrate of Aurora-B, and induced polyploidy and apoptosis. Furthermore, AMG 900 potentiated the antiproliferative effects of paclitaxel and ixabepilone at low nanomolar concentrations. In mice, AMG 900 significantly inhibited the growth of MDA-MB-231 (F11; parental), MDA-MB-231 (F11) PTX-r (paclitaxel-resistant variant), and DU4475 xenografts. The combination of AMG 900 with docetaxel enhanced tumor inhibition in MDA-MB-231 (F11) xenografts compared with either monotherapy. Notably, combining AMG 900 with ixabepilone resulted in regressions of MDA-MB-231 (F11) PTX-r xenografts, in which more than 50% of the tumors failed to regrow 75 days after the cessation of drug treatment. These findings suggest that AMG 900, alone and in combination with MTAs, may be an effective intervention strategy for the treatment of metastatic breast cancer and provide potential therapeutic options for patients with multidrug-resistant tumors. Mol Cancer Ther; 12(11); 2356–66. ©2013 AACR.
Loss of a Negative Feedback Loop Involving Pea3 and Cyclin D2 Is Required for Pea3-Induced Migration in Transformed Mammary Epithelial Cells
Authors: Ladam Franck , Damour Isabelle , Dumont Patrick , Kherrouche Zoulika , de Launoit Yvan , Tulasne David , Chotteau-Lelievre Anne 
Published: August 2013

Abstract
The Ets family transcription factor Pea3 (ETV4) is involved in tumorigenesis especially during the metastatic process. Pea3 is known to induce migration and invasion in mammary epithelial cell model systems. However, the molecular pathways regulated by Pea3 are still misunderstood. In the current study, using in vivo and in vitro assays, Pea3 increased the morphogenetic and tumorigenic capacity of mammary epithelial cells by modulating their cell morphology, proliferation, and migration potential. In addition, Pea3 overexpression favored an epithelial–mesenchymal transition (EMT) triggered by TGF-β1. During investigation for molecular events downstream of Pea3, Cyclin D2 (CCND2) was identified as a new Pea3 target gene involved in the control of cellular proliferation and migration, a finding that highlights a new negative regulatory loop between Pea3 and Cyclin D2. Furthermore, Cyclin D2 expression was lost during TGF-β1–induced EMT and Pea3-induced tumorigenesis. Finally, restored Cyclin D2 expression in Pea3-dependent mammary tumorigenic cells decreased cell migration in an opposite manner to Pea3. As such, these data demonstrate that loss of the negative feedback loop between Cyclin D2 and Pea3 contributes to Pea3-induced tumorigenesis.
Implications: This study reveals molecular insight into how the Ets family transcription factor Pea3 favors EMT and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 target gene. Mol Cancer Res; 11(11); 1412–24. ©2013 AACR.
Extending the pharmacokinetic half-life of coagulation factors by fusion to recombinant albumin
Authors: Pipe Steven W. , Weimer Thomas , Schulte Stefan , Metzner Hubert J. 
Published: August 2013

SummaryThe prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due to the suboptimal half-lives of the products commercially available and currently in use, e.g. recombinant factor IX (rFIX) and recombinant factor VIIa (rFVIIa), respectively. The extension of the half-lives of rFIX and rFVIIa could allow for longer intervals between infusions and could thereby improve adherence and clinical outcomes and may improve quality of life. Albumin fusion is one of a number of different techniques currently being examined to prolong the half-life of rFIX and rFVIIa. Results from a phase I clinical trial demonstrated that the recombinant fusion protein linking FIX to albumin (rIX-FP) has a five-times longer half-life than rFIX, and preclinical studies with the recombinant fusion protein linking FVIIa to albumin (rVIIa-FP) suggest that rVIIa-FP possesses a significantly extended half-life versus rFVIIa. In this review, we describe albumin fusion technology and examine the recent progress in the development of rIX-FP and rVIIa-FP.
Classification of Contractual Agreements in Comparative and Islamic Jurisdictions: Does it Make Any Sense?
Authors: Fayyad Mahmoud 
Published: August 2013

Abstract
Comparative legal systems differ in the organization of the manifestation of parties’ expressions when making legal transactions where an external action does not reflect the real intention of this party. Most jurisdictions, including Islamic law, follow the objective theory of agreements while the Conterminal legal system adopts the subjective approach. Despite the fact that many scholars spent much efforts to clarify this classification, the importance of this classification may be modest; these legal systems organize some basic doctrines, with regard to the formation of a contract (namely: the revocability of offer, the need for communication of acceptance and the rules of interoperation), in a manner that may contradict with its general theory of making agreement. In other words, the organization of these doctrines has very little significant differences in result between these legal systems. Islamic law has the same result as well. This article aims at explaining these doctrines and differences.
Analysing the Islamic Prohibition on Ribā: A Prohibition on Substance or Form?
Authors: Harasani Hamid 
Published: August 2013

Abstract
This article explores the ban on usury under Islamic law, and assesses whether the ban is one of substance or form. Further, it also presents an objective test that will determine whether certain financial transactions—that aim to circumvent the ban on usury—are merely ḥiyal (legal ruses). The discussion of these issues is not a plain theoretical exercise; this type of work is necessary for financial institutions that aim to create innovative Islamic-compliant schemes without overstepping the boundaries of Islamic law.