bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conductus as Analgesic
Authors: Gillingham Bryan 
Published: August 2013

One of the difficulties in creating an adequate picture of the contextual situation for music, other than that clearly associated with the liturgy, in the Middle Ages, is the paucity of accounts describing performance circumstances. We know little about the social milieu and purposes attending genres marginal to the liturgy such as the conductus and thirteenth-century motet. A manuscript which seems to redress this problem, albeit for one very specific instance, is Vat. lat. 2854 in the Vatican library in Rome.
This manuscript is unusual in that it contains not only music but a detailed account of why the music was written. The author, Bonaiutus de Casentino, active in the circle of Pope Boniface VIII, prepared the manuscript in the last decade of the thirteenth century at Rome. The document includes various poems, sacred and secular, as well as two Latin songs written in late Franconian notation. One of the pieces is a two-voice conductus (Hec medela corporalis) which was written, according to the account of Bonaiutus himself, in order to cure the maladies of an ailing pontif. The pontifical complaints seemed to be both psychological and intestinal in nature. It was the hope of Bonaiutus not only to provoke laughter (always a curative), but also to cleanse the papal bowels through his composition. Although one cannot generalize on the basis of this single incident, it does yield a fascinating glimpse into a possible venue for the conductus.
Le « dynamisme » d’une tradition : la danse à tambour chez les Dènès (Canada, Territoires du Nord-Ouest)
Authors: Beaudry Nicole 
Published: August 2013

L’auteure décrit les transformations qu’a subie la tradition de danse chez les Dènès des Territoires du Nord-Ouest. Par ailleurs, certains aspects de cette tradition fournissent l’occasion d’examiner, en même temps, les sources sur lesquelles s’appuient ses recherches. Ainsi, alternant entre les documents anciens dits « historiques » et ceux plus récents émanant plus directement de la tradition orale, l’auteure en vient à réfléchir sur la nature même de cette discipline que l’on nomme ethnohistoire et sur ses applications. Finalement, elle conclut en offrant un bref aperçu d’un sens historique autochtone axé plus sur la notion d’espace territorial que sur celle du temps.
Dramaturgies d’Afrique et des diasporas sur la scène québécoise : décapage esthétique aux couleurs du temps
Authors: Chalaye Sylvie Alix 
Published: August 2013

La scène québécoise a contribué, ces dernières années, à révéler les dramaturgies contemporaines d’Afrique noire et des diasporas à travers le travail de Denis Marleau sur les textes du Béninois José Pliya. Cette reconnaissance d’une écriture contemporaine africaine est aussi passée par des productions originales comme celle de Big Shoot de l’Ivoirien Koffi Kwahulé au Théâtre Denise-Pelletier à Montréal, sous la direction de Kristian Frédric. L’Afrique des villages n’est pas au rendez-vous de ces spectacles. Ce sont au contraire des histoires de fin du monde et d’altérité qui résonnent avec force. Évacuant tout exotisme pour prendre « les couleurs du temps » au sens météorologique et cosmique, ces mises en scène aborde sans détour la trame métaphysique des dramaturgies africaines et touchent d’emblée au discours ontologique d’un théâtre de la recherche de soi dans le chaos du monde.
How Speech Modifies Visual Attention
Authors: Spence Ian , Jia Andrew , Feng Jing , Elserafi Jonny , Zhao Ying 
Published: August 2013

SummaryAuditory distractions can have serious consequences in critical situations such as driving. Mobile phones, radios, media players, and information devices that interpret and produce speech are increasingly common in vehicles, but the threats to visual attention are not yet fully understood. In three experiments, we found that most speech tasks had relatively small adverse effects on the detection of a briefly presented target among distractors across a 60° subarea of the visual field. Although there was a little impact on detectability, moderately difficult speech tasks slowed responding relative to silence. Our most demanding condition—generating and speaking a word beginning with the last letter of another word—had the greatest effects on accuracy and latency, with responding slowed by about 900 ms. An impairment of this magnitude presents a significant threat to safe driving and calls into question the belief that hands‐free voice‐controlled devices are the answer to the problem of driver distraction. Copyright © 2013 John Wiley & Sons, Ltd.
A Nontoxic Additive to Introduce X‐Ray Contrast into Poly(Lactic Acid). Implications for Transient Medical Implants Such as Bioresorbable Coronary Vascular Scaffolds
Authors: Wang Yujing , van den Akker Nynke M. S. , Molin Daniël G. M. , Gagliardi Mick , van der Marel Cees , Lutz Martin , Knetsch Menno L. W. , Koole Leo H. 
Published: August 2013

AbstractBioresorbable coronary vascular scaffolds are about to revolutionize the landscape of interventional cardiology. These scaffolds, consisting of a poly(L‐lactic acid) interior and a poly(d,l‐lactic acid) surface coating, offer a genuine alternative for metallic coronary stents. Perhaps the only remaining drawback is that monitoring during implantation is limited to two X‐ray contrast points. Here, a new approach to make the biodegradable scaffolds entirely radiopaque is explored. A new contrast agent is designed and synthesized. This compound is miscible with poly(d,l‐lactic acid) matrix, and nontoxic to multiple cell types. Blends of poly(d,l‐lactic acid) and the contrast agent are found to be hemocompatible, noncytotoxic, and radiopaque. The data show that it is possible to manufacture fully radiopaque bioresorbable coronary vascular scaffolds. Whole‐stent X‐ray visibility helps interventionalists ensure that the scaffold deploys completely. This important advantage may translate into improved safety, accuracy, and clinical performance of cardiac stents.
A transient myelodysplastic/myeloproliferative neoplasm in a patient with cardio‐facio‐cutaneous syndrome and a germline BRAF mutation
Authors: Sekiguchi Kazuhito , Maeda Tomoki , Suenobu So‐ichi , Kunisaki Nobutaka , Shimizu Miki , Kiyota Kyoko , Handa Yo‐suke , Akiyoshi Kensuke , Korematsu Seigo , Aoki Yoko , Matsubara Yoichi , Izumi Tatsuro 
Published: August 2013

ABSTRACTA male infant, born at 32 weeks gestation by cesarean because of hydrops fetalis, presented with multiple anomalies, such as sparse and curly scalp hair, absent eyebrows, frontal bossing, an atrial septal defect, pulmonary artery stenosis, and whole myocardial thickening. He was clinically diagnosed with cardio‐facio‐cutaneous (CFC) syndrome, and was confirmed to have a germline V‐raf murine sarcoma viral oncogene homologue B1 (BRAF) c.721 A>C mutation. At 1 month of age, he presented with a transient myelodysplastic/myeloproliferative neoplasm (MDS/MPN), which improved within a month without the administration of antineoplastic agents. This is the first report of CFC syndrome with MDS/MPN. The coexistence of MDS/MPN may be related to this BRAF c.721 A>C mutation. © 2013 Wiley Periodicals, Inc.
Bone marrow transplantation in Schimke immuno‐osseous dysplasia
Authors: Baradaran‐Heravi Alireza , Lange Jonas , Asakura Yumi , Cochat Pierre , Massella Laura , Boerkoel Cornelius F. 
Published: August 2013

AbstractSchimke immuno‐osseous dysplasia (SIOD, OMIM 242900) is a rare autosomal recessive multisystem childhood disorder characterized by short stature, renal failure, T‐cell immunodeficiency, and hypersensitivity to genotoxic agents. SIOD is associated with biallelic mutations in SMARCAL1 (SWI/SNF‐related matrix‐associated actin‐dependent regulator of chromatin, subfamily a‐like 1), which encodes a DNA stress response enzyme with annealing helicase activity. Two features of SIOD causing much morbidity and mortality are bone marrow failure and T‐cell deficiency with the consequent opportunistic infections. To address the safety and efficacy of bone marrow transplantation (BMT) in SIOD, we reviewed the outcomes of the only five SIOD patients known to us in whom bone marrow or hematopoietic stem cell transplantation has been attempted. We find that only one patient survived the transplantation procedure and that the existing indicators of a good prognosis for bone marrow transplantation were not predictive in this small cohort. Given these observations, we also discuss some considerations for the poor outcomes. © 2013 Wiley Periodicals, Inc.
Efficient Formation of Luminescent Lanthanide(III) Complexes by Solid‐Phase Synthesis and On‐Resin Screening
Authors: Nakamura Tatsuya , Mizukami Shin , Tanaka Miho , Kikuchi Kazuya 
Published: August 2013

AbstractTime‐resolved luminescence measurements of luminescent lanthanide complexes have advantages in biological assays and high‐throughput screening, owing to their high sensitivity. In spite of the recent advances in their energy‐transfer mechanism and molecular‐orbital‐based computational molecular design, it is still difficult to estimate the quantum yields of new luminescent lanthanide complexes. Herein, solid‐phase libraries of luminescent lanthanide complexes were prepared through amide‐condensation and Pd‐catalyzed coupling reactions and their luminescent properties were screened with a microplate reader. Good correlation was observed between the time‐resolved luminescence intensities of the solid‐phase libraries and those of the corresponding complexes that were synthesized by using liquid‐phase chemistry. This method enabled the rapid and efficient development of new sensitizers for SmIII, EuIII, and TbIII luminescence. Thus, solid‐phase combinatorial synthesis combined with on‐resin screening led to the discovery of a wide variety of luminescent sensitizers.
Crosswind‐based optimization of multiple runway orientations
Authors: Chang Sze‐Wei 
Published: August 2013

SummaryThe runway orientation must satisfy the operational requirements of aircraft for landing and takeoff. Actually, the runway orientation is the result of compromises between the airport usability (wind coverage) and additional factors, such as available land, existing obstructions, topographic difficulties, flight path interference among runways and airports, noise pollution, and other environmental impacts. Therefore, the solution of a combination of acceptable runway orientations, which avoids excessive crosswinds at least 95% of the time, as well as the optimal orientation solution, is essential to conduct those compromises in the runway orientation analysis. The objective of this paper is to develop a computer model, named the optimization of multiple runway orientations model, which is capable of simultaneously providing a combination of acceptable runway orientations, changing the allowable crosswind limit flexibly, and determining the optimal orientations of multiple runway configurations. Instead of visual estimation or geometric computation, this paper presents an analytical method for wind coverage analysis. The model is mainly running in spreadsheet and Visual Basic for Applications (VBA). The numerical example and comparison show that the optimization of multiple runway orientations model is competitively accurate and convenient in comparison with previous ones. This paper presents an up‐to‐date model for the optimization of multiple runway orientations. By combining it with the geographic information system obstructions model, it can become an essential element of a future model for airport development cost minimization that combines airfield land use, earthwork volume, and cost estimation modules. Copyright © 2013 John Wiley & Sons, Ltd.
Chiral chromatographic resolution of antiepileptic drugs and their metabolites: a challenge from the optimization to the application
Authors: Fortuna Ana , Alves Gilberto , Falcão Amílcar 
Published: August 2013

ABSTRACTA large number of the antiepileptic drugs (AEDs) presently available for clinical practice are chiral compounds while others, although achiral, may originate pharmacologically active chiral metabolites in vivo. The well‐known implications of chirality in pharmacokinetics and pharmacodynamics demand the investigation of pharmacological properties for a racemic mixture and each enantiomer. To achieve these objectives, appropriate chiral analytical methods must be available. This article provides the first review of the current state of the art in chiral chromatographic methods available for quantifying enantiomers of AEDs in distinct matrices. Particular attention is paid to the methodological aspects and optimization strategies that successfully allow enantiomeric chromatographic separation of chiral AEDs and/or metabolites. Furthermore, the relevance of these methods in supporting the discovery and development of chiral AEDs is emphasized. In parallel and whenever available, the principal validation parameters are herein considered and related to the stage of drug discovery and development. In an attempt to optimize anticonvulsant activity and simultaneously diminish toxic effects, many pharmaceutical companies have started to manufacture single enantiomers. Therefore, chiral chromatographic techniques will be essential and the information herein compiled can be used as a framework for developing them. Copyright © 2013 John Wiley & Sons, Ltd.
The effect of mobile phase composition in the enantioseparation of pharmaceutically relevant compounds with polysaccharide‐based stationary phases
Authors: Sardella Roccaldo , Ianni Federica , Lisanti Antonella , Marinozzi Maura , Scorzoni Stefania , Natalini Benedetto 
Published: August 2013

ABSTRACTMobile phase variables have a deep influence on the chromatographic behavior with polysaccharide‐based chiral stationary phases. Basic additives are generally used to minimize peak broadening arising from unwanted interactions between polar solutes and underivatized silanols. However, basic additives can improve enantioselectivity through disruption of hydrogen bonds and modification of the polymer morphology. Acidic additives are incorporated into the mobile phase during the analysis of acidic compounds as efficiency enhancers. Acidic additives can also improve enantioselectivity by minimizing within the chiral recognition site nonenantioselective retention. Peak shape without acidic additive in the eluent could be severely distorted during the analysis of salified compounds. Concentration and type of alcohol modifier can have an effect on the morphology of the polymer. The different winding of the chiral selector, caused by alcohol modifiers of different size/shape, ultimately results in different stereo environment of the chiral cavities in the polymer chain. Trace amounts of water in normal‐phase eluents can affect retention time, tailing, and resolution. Deliberate addition of water to the eluent can improve peak resolution and save analysis time and solvent needs. Immobilized‐type polysaccharide‐derived chiral stationary phases offer new selectivity profiles and often improved enantioselectivity. Copyright © 2013 John Wiley & Sons, Ltd.
Solar Fuels: Photoelectrosynthesis of CO from CO2 at p‐Type Si using Fe Porphyrin Electrocatalysts
Authors: Alenezi Khalaf , Ibrahim Saad K. , Li Peiyi , Pickett Christopher J. 
Published: August 2013

AbstractPhotoelectrocatalytic conversion of CO2 to CO can be driven at a boron‐doped, hydrogen terminated, p‐type silicon electrode using a meso‐tetraphenylporphyrin FeIII chloride in the presence of CF3CH2OH as a proton source and 0.1 M [NBu4][BF4]/MeCN/5 % DMF (v/v) as the electrolyte. Under illumination with polychromatic light, the photoelectrocatalysis operates with a photovoltage of about 650 mV positive of that for the dark reaction. Carbon monoxide is produced with a current efficiency >90 % and with a high selectivity over H2 formation. Photoelectrochemical current densities of 3 mA cm−2 at −1.1 V versus SCE are typical, and 175 turnovers have been attained over a 6 h period. Cyclic voltammetric data are consistent with a turnover frequency of ${k{{{\rm Si}\hfill \atop {\rm obs}\hfill}}}$=0.24×104 s−1 for the photoelectrocatalysis at p‐type Si at −1.2 V versus SCE this compares with ${k{{{\rm C}\hfill \atop {\rm obs}\hfill}}}$=1.03×104 s−1 for the electrocatalysis in the dark on vitreous carbon at a potential of −1.85 V versus SCE.
Evolution of a Multicomponent System: Computational and Mechanistic Studies on the Chemo‐ and Stereoselectivity of a Divergent Process
Authors: Llabrés Salomé , Vicente‐García Esther , Preciado Sara , Guiu Cristina , Pouplana Ramon , Lavilla Rodolfo , Luque F. Javier 
Published: August 2013

AbstractThe evolution of a ternary molecular system (imine, diene and nitrile) is analyzed to disclose the pathways leading to a divergent synthetic outcome. The Lewis acid catalyzed reaction between cyclohexadiene, 2‐phenyl‐indol‐3‐one and acetonitrile yields the imino‐Diels–Alder adduct as the major product together with minor amounts of the Mannich–Ritter‐amidine product. The experimental and computational data show that the relative orientation of the initial reactants dictates the synthetic outcome. The exo approach between imine and diene leads to the Diels–Alder adduct in a concerted process, whereas the endo mode leads to a polarized intermediate, which is trapped by acetonitrile to yield the multicomponent adduct.
A case study for biochemical application porting in european grids and clouds
Authors: Kertesz Attila , Otvos Ferenc , Kacsuk Peter 
Published: August 2013

SUMMARYResearchers of various disciplines ranging from Life Sciences and Astronomy to Computational Chemistry create and use scientific applications producing large amount of complex data relying heavily on compute‐intensive modeling, simulation, and analysis. Grid computing provides an efficient way for parallelizing and gridifying computational and data intensive applications of various research fields including molecular dynamics. In this paper, we examine a biochemical application that generates conformers by unconstrained molecular dynamics at high temperature to overcome conformational bias then finishes each conformer by simulated annealing and energy minimization to obtain reliable structures. We provide a general way for turning biochemical applications into scientific workflows that can be executed through Web‐based portals exploiting the computational power of available distributed computing infrastructures such as production grids, clusters, supercomputers, or clouds. First, we describe the application porting process, then provide experimental results that show the achieved speed‐up of the ported application on three different infrastructure; finally, we show how to design a more attractive and easily usable graphical interface for this application. Copyright © 2013 John Wiley & Sons, Ltd.
Application of the escape factor method for determination of excited states densities in a low‐pressure argon radio‐frequency discharge
Authors: Sushkov V. P. , Do H. T. , Hippler R. 
Published: August 2013

AbstractReabsorption of the emitted light in the plasma volume has recently been used for density measurements of the lower level of optical transition by interpretation of emission spectra employing the escape factor concept. Following this idea, we apply this method to a radio‐frequency argon discharge. By revising the theoretical background, the impact of different assumptions on excited species spatial distributions is investigated. Comparing with 1s5 and 1s4 concentrations obtained with laser absorption spectroscopy, the range of applicability of those assumptions is analyzed at different discharge parameters. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Ring Closing and Macrocyclization of β‐Dipeptides by Olefin Metathesis
Authors: Sundararaju Basker , Sridhar Tailor , Achard Mathieu , Sharma Gangavaram V. M. , Bruneau Christian 
Published: August 2013

Abstractβ‐Dipeptides containing allyl groups at different positions on the peptide backbone were prepared. Ring‐closing metathesis of these β‐dipeptides with the use of a ruthenium catalyst led to medium‐sized cyclic β‐dipeptides and macrocyclic tetrapeptides, depending on the nature of the allylic substitution on the β‐dipeptides.
Transition‐Metal‐Catalyzed Regioselective Alkylation of Indoles with Alcohols
Authors: Putra Anggi Eka , Takigawa Kei , Tanaka Hatsuki , Ito Yoshihiko , Oe Yohei , Ohta Tetsuo 
Published: August 2013

AbstractThe regioselective alkylation of indoles with alcohols as alkylating reagents was developed by using Pd/C or RuCl2(PPh3)3/DPEphos {DPEphos = bis[(2‐diphenylphosphanyl)phenyl] ether}as catalysts. The reaction of indole with benzyl alcohol in the presence of Pd/C and K2CO3 at 80 °C for 24 h without any solvent under in air yielded 90 % of 3‐benzylindole. The corresponding 3‐benzylindole was obtained in 99 % yield when the reaction was catalyzed by RuCl2(PPh3)3/DPEphos in the presence of K3PO4 at 165 °C for 24 h under argon. Several types of alcohols were treated with indoles under these conditions to give the corresponding 3‐alkylated indoles in high yields (up to 99 %). This reaction may involve the catalyst‐mediated transformation of alcohols to aldehydes, nucleophilic addition of indole to the resulting aldehydes accompanied by dehydration, and then hydrogenation.
Synthesis of Adamantane‐Based Trimeric Benzoboroxoles
Authors: Claes Dorith , Holzapfel Malte , Clausen Nadine , Maison Wolfgang 
Published: August 2013

AbstractBenzoboroxoles are known to bind 1,2‐diol motifs in carbohydrates in an aqueous environment. Their binding properties have been shown to be dependent on additional recognition sites such as peptides and the number of binding epitopes. In this paper we describe the synthesis of trimeric benzoboroxoles based on a rigid adamantyl core structure. The conjugates are assembled using copper‐catalyzed click reactions of azide scaffolds with alkynyl‐functionalized benzoboroxoles. The design of our trimeric benzoboroxoles followed a biomimetic principle and imitates the trimeric structure of some natural carbohydrate binding proteins (lectins). With an assortment of appropriately functionalized (3 + 1) adamantane scaffolds, trimeric benzoboroxoles have been generated which were combined with additional functional molecules such as dyes and peptides. In summary, we report a highly effective synthetic approach to modular trimeric boronolectines for the assembly of carbohydrate sensors.
Pd0‐Catalyzed Hydrogenolysis of a Bicyclic Allylic Diacetate
Authors: Muchow Gunter , Brunel Jean Michel 
Published: August 2013

AbstractThe Pd0‐catalyzed hydrogenolysis of 2,3‐bis(acetoxymethyl)bicyclo[2.2.1]hepta‐2,5‐diene (1) is described. The influence of various hydride sources on the reaction, as well as different experimental conditions and organophosphorus ligands have been rigorously investigated.
Modified Sulfonated Poly(ether ether ketone) Based Mixed Matrix Membranes for Direct Methanol Fuel Cells
Authors: Meenakshi S. , Bhat S. D. , Sahu A. K. , Sridhar P. , Pitchumani S. 
Published: August 2013

AbstractMixed matrix membranes based on zeolite 4A‐methane sulfonic acid (MSA)‐sulfonated poly(ether ether ketone) (SPEEK) are evaluated as a potential polymer electrolyte membrane (PEM) for direct methanol fuel cells (DMFCs). Ion‐exchange capacity, sorption of water, and water–methanol mixture, proton conductivity, and methanol permeability for the mixed‐matrix membranes have been extensively investigated. The mixed‐matrix membranes are also characterized for their cross‐sectional morphology, mechanical, and thermal properties. DMFCs employing SPEEK‐MSA (20 wt.%) blend, zeolite 4A (4 wt.%)‐SPEEK‐MSA (20 wt.%) mixed matrix membranes deliver peak power densities of 130 and 159 mW cm–2, respectively; while a peak power density of only 95 mW cm–2 is obtained for the DMFC employing pristine SPEEK membrane at 70 °C. The results showed that these SPEEK based mixed matrix membranes exhibit higher DMFC performance and lower methanol permeability in comparison to Nafion‐117 membrane.