P-448 Placental histopathology in frozen embryo transfer HRT induced IVF pregnancies and non-IVF pregnancies and its correlation with maternal and fetal outcomes: a prospective case-control study
Authors: Khullar S , Yousuf S , Mehboob A 
Published: July 2024

Abstract

Study question
Is Placental histopathology altered in Frozen Embryo transfer, HRT induced IVF pregnancies when compared to non-IVF pregnancies; if yes,any implications on maternal and fetal outcome?

Summary answer
Pathological placental lesions and adverse maternal outcomes were found to be significantly higher in IVF pregnancies compared to non-IVF pregnancies.

What is known already
Studies on placental histopathology in IVF pregnancies suggest that there may be differences compared to naturally conceived pregnancies. Some research indicates an increased risk of certain placental abnormalities such as changes in vascularization and structure (Uroka Belak, et al., 2023). Additionally, alterations in gene expressions and epigenetic modifications in placenta have been observed in IVF pregnancies. However, it is essential to note that findings can vary, and more research is needed to fully understand the implications and potential long-term effects.

Study design, size, duration
Prospective, single centre, comparative clinical study, including 100 pregnancies between November, 2022 and November, 2023; 50 FET HRT induced IVF pregnancies, 50 non-IVF pregnancies.

Participants/materials, setting, methods
Patients aged 32-45 years, &gt;34 weeks gestation, with no associated maternal and obstetrical complications were recruited after proper screening and informed consent. Among 100 pregnancies, we compared placental HPE using the Amsterdam Placental Workshop Group Consensus and feto-maternal outcomes between FET HRT induced IVF pregnancies and non-IVF pregnancies. We used Chi-square test to compare groups(p &lt; 0.05).

Main results and the role of chance
Out of 100 participants, 50 were frozen embryo transfer, HRT induced IVF pregnancies and 50 were non-IVF pregnancies. Out of 50 IVF pregnancies; 27(54%) had pathological placental lesions, of which 17(63%) were noted to have adverse maternal outcomes and 6(22.2%) had adverse fetal outcomes. Out of 50 non-IVF pregnancies, 4(8%) had pathological placental lesions; of which 1(25%) were noted to have adverse maternal outcomes and 1(25%) had adverse fetal outcomes. On comparing these 2 groups, our result was found to be statistically significant(p &lt; 0.05).

Limitations, reasons for caution
This study has some limitations owing to it being a single centered comparative trial, possibility of observer bias in histopathological examination and that the study is restricted to HRT induced IVF pregnancies.

Wider implications of the findings
This study reveals valuable insights into potential differences in placental and fetal development. Understanding these variances could influence clinical practices, patient counseling, and contribute to advancements in assisted reproductive technologies. Additionally, insights into long-term health outcomes for both mothers and babies may emerge, guiding future research and healthcare strategies.

Trial registration number
Not applicable