bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study
Authors: Visser A Willemien , Ioan-Facsinay Andreea , de Mutsert Renée , Widya Ralph L , Loef Marieke , de Roos Albert , le Cessie Saskia , den Heijer Martin , Rosendaal Frits R , Kloppenburg Margreet ,   NEO Study Group
Published: January 2014

Abstract
Introduction
Obesity, usually characterized by the body mass index (BMI), is a risk factor for hand osteoarthritis (OA). We investigated whether adipose tissue and abdominal fat distribution are associated with hand OA.

Methods
The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort aged 45 to 65 years, including 5315 participants (53% women, median BMI 29.9 kg/m2). Fat percentage and fat mass (FM) (kg) were estimated using bioelectrical impedance analysis. The waist-to-hip ratio (WHR) was calculated. In 1721 participants, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) (cm2) were assessed using abdominal MR imaging. Hand OA was defined according to the ACR criteria.
Odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association of fat percentage, FM, WHR, VAT and SAT with hand OA using logistic regression analyses per standard deviation, stratified by sex and adjusted for age.

Results
Hand OA was present in 8% of men and 20% of women. Fat percentage was associated with hand OA in men (OR 1.34 (95% CI 1.11 to 1.61)) and women (OR 1.26 (1.05 to 1.51)), as was FM. WHR was associated with hand OA in men (OR 1.45 (1.13 to 1.85)), and to a lesser extent in women (OR 1.17 (1.00 to 1.36)). Subgroup analysis revealed that VAT was associated with hand OA in men (OR1.33 (1.01 to 1.75)). This association increased after additional adjustment for FM (OR 1.51 (1.13 to 2.03)).

Conclusions
Fat percentage, FM and WHR were associated with hand OA. VAT was associated with hand OA in men, suggesting involvement of visceral fat in hand OA.
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide
Authors: Cochrane Dawn R , Bernales Sebastián , Jacobsen Britta M , Cittelly Diana M , Howe Erin N , D’Amato Nicholas C , Spoelstra Nicole S , Edgerton Susan M , Jean Annie , Guerrero Javier , Gómez Francisco , Medicherla Satyanarayana , Alfaro Iván E , McCullagh Emma , Jedlicka Paul , Torkko Kathleen C , Thor Ann D , Elias Anthony D , Protter Andrew A , Richer Jennifer K 
Published: January 2014

Abstract
Introduction
The androgen receptor (AR) is widely expressed in breast cancers and has been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast cancers that retain AR. However, controversy exists regarding the role of AR, particularly in ER + tumors. Enzalutamide, an AR inhibitor that impairs nuclear localization of AR, was used to elucidate the role of AR in preclinical models of ER positive and negative breast cancer.

Methods
We examined nuclear AR to ER protein ratios in primary breast cancers in relation to response to endocrine therapy. The effects of AR inhibition with enzalutamide were examined in vitro and in preclinical models of ER positive and negative breast cancer that express AR.

Results
In a cohort of 192 women with ER + breast cancers, a high ratio of AR:ER (≥2.0) indicated an over four fold increased risk for failure while on tamoxifen (HR = 4.43). The AR:ER ratio had an independent effect on risk for failure above ER % staining alone. AR:ER ratio is also an independent predictor of disease-free survival (HR = 4.04, 95% CI: 1.68, 9.69; p = 0.002) and disease specific survival (HR = 2.75, 95% CI: 1.11, 6.86; p = 0.03). Both enzalutamide and bicalutamide inhibited 5-alpha-dihydrotestosterone (DHT)-mediated proliferation of breast cancer lines in vitro; however, enzalutamide uniquely inhibited estradiol (E2)-mediated proliferation of ER+/AR + breast cancer cells. In MCF7 xenografts (ER+/AR+) enzalutamide inhibited E2-driven tumor growth as effectively as tamoxifen by decreasing proliferation. Enzalutamide also inhibited DHT- driven tumor growth in both ER positive (MCF7) and negative (MDA-MB-453) xenografts, but did so by increasing apoptosis.

Conclusions
AR to ER ratio may influence breast cancer response to traditional endocrine therapy. Enzalutamide elicits different effects on E2-mediated breast cancer cell proliferation than bicalutamide. This preclinical study supports the initiation of clinical studies evaluating enzalutamide for treatment of AR+ tumors regardless of ER status, since it blocks both androgen- and estrogen- mediated tumor growth.
GraphProt: modeling binding preferences of RNA-binding proteins
Authors: Maticzka Daniel , Lange Sita J , Costa Fabrizio , Backofen Rolf 
Published: January 2014

AbstractWe present GraphProt, a computational framework for learning sequence- and structure-binding preferences of RNA-binding proteins (RBPs) from high-throughput experimental data. We benchmark GraphProt, demonstrating that the modeled binding preferences conform to the literature, and showcase the biological relevance and two applications of GraphProt models. First, estimated binding affinities correlate with experimental measurements. Second, predicted Ago2 targets display higher levels of expression upon Ago2 knockdown, whereas control targets do not. Computational binding models, such as those provided by GraphProt, are essential for predicting RBP binding sites and affinities in all tissues. GraphProt is freely available at http://www.bioinf.uni-freiburg.de/Software/GraphProt.
Randomized Noninferiority Trial of Telephone Versus In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer
Authors: Schwartz Marc D. , Valdimarsdottir Heiddis B. , Peshkin Beth N. , Mandelblatt Jeanne , Nusbaum Rachel , Huang An-Tsun , Chang Yaojen , Graves Kristi , Isaacs Claudine , Wood Marie , McKinnon Wendy , Garber Judy , McCormick Shelley , Kinney Anita Y. , Luta George , Kelleher Sarah , Leventhal Kara-Grace , Vegella Patti , Tong Angie , King Lesley 
Published: January 2014

Purpose Although guidelines recommend in-person counseling before BRCA1/BRCA2 gene testing, genetic counseling is increasingly offered by telephone. As genomic testing becomes more common, evaluating alternative delivery approaches becomes increasingly salient. We tested whether telephone delivery of BRCA1/2 genetic counseling was noninferior to in-person delivery. Patients and Methods Participants (women age 21 to 85 years who did not have newly diagnosed or metastatic cancer and lived within a study site catchment area) were randomly assigned to usual care (UC; n = 334) or telephone counseling (TC; n = 335). UC participants received in-person pre- and post-test counseling; TC participants completed all counseling by telephone. Primary outcomes were knowledge, satisfaction, decision conflict, distress, and quality of life; secondary outcomes were equivalence of BRCA1/2 test uptake and costs of delivering TC versus UC. Results TC was noninferior to UC on all primary outcomes. At 2 weeks after pretest counseling, knowledge (d = 0.03; lower bound of 97.5% CI, −0.61), perceived stress (d = −0.12; upper bound of 97.5% CI, 0.21), and satisfaction (d = −0.16; lower bound of 97.5% CI, −0.70) had group differences and confidence intervals that did not cross their 1-point noninferiority limits. Decision conflict (d = 1.1; upper bound of 97.5% CI, 3.3) and cancer distress (d = −1.6; upper bound of 97.5% CI, 0.27) did not cross their 4-point noninferiority limit. Results were comparable at 3 months. TC was not equivalent to UC on BRCA1/2 test uptake (UC, 90.1%; TC, 84.2%). TC yielded cost savings of $114 per patient. Conclusion Genetic counseling can be effectively and efficiently delivered via telephone to increase access and decrease costs.
Interdisciplinary connections of descriptive geometry and related sections of higher mathematics
Authors: Дмитриева  , Dmitrieva I. , Иванов  , Ivanov G. , Серегин  , Seregin V. , Муравьев  , Muravev K. 
Published: January 2014

Traditional course of descriptive geometry as an academic
discipline is generally providing for engineering graphics and
some sections (such as toothed gears worm-gear drives) related to
theories of mechanisms and details for cars. Its transformation in
a course of engineering geometry is caused by requirements of
production, current trends and world experience related to engineering
skills training for their professional design activity [1, 2, 3].
Expansion of descriptive geometry subject by forms of multidimensional
space allows establish cross-subjects connection with related
mathematical and all-technical disciplines. This thesis justice
is confirmed by examples of evident geometrical interpretation of
linear equations systems decision, concepts related to private derivatives
and multiple integrals. According to authors an expansion
of descriptive geometry applications area has to raise descriptive
geometry role in higher professional education system.
User experience of distance learning during graphic disciplines teaching for students of engineering construction and economic specialties
Authors: Жилкина  , Zhilkina T. , Матусевич  , Matusevich V. 
Published: January 2014

The results of computer technologies implementation
in teaching practice at the Chair of Descriptive Geometry and
Graphics of MSAMI&amp;S have been presented. Executed studies
have shown that the teaching technology is determined by peculiarities
of graphic disciplines teaching, in particular by the need
of large graphic information transmission from teacher to student.
The result of adaptation of traditional teaching and methodical
materials on graphics disciplines to distance learning forms is the
formation of information system, providing the use of IT in the
distance learning in the form of on-line video-lectures.
Organization and Carrying of Academic Competitions on Descriptive Geometry at South-West State University
Authors: Альшакова  , Alshakova Elena 
Published: January 2014

The technology of academic competition on descriptive
geometry carrying at South-West State University is considered.
The academic competitions are intended to identify the most capable
students. Participation in academic competitions are encouraged
by diplomas of all-Russia student&#180;s academic competitions.
These diplomas enable the students to receive an additional scholarship
for their research activities within half a year, and also the
prize in the South-Western State University. The descriptive geometry
tasks related to academic competitions that had been carried
in the South-Western State University in different years have been
presented in this paper. The decisions have been given for the
majority of tasks.
Inclusion and Integration of the Disabled into the Labor Market Against the Background of the New Regulations in Germany
Authors: Jodkowska Lilianna 
Published: January 2014

The aim of the article is to present new regulations introduced by the Third Book of the Social Code in Germany that concern a reform of the labor market's active instruments gathered under the name "Instumentenreform". One of the main objectives of the reform is to improve the quality of programs and projects that activate the unemployed, but also to make efforts to include in the labor market groups that have not been activated in such a way so far. One of such groups are the disabled trained and employed in Invalids' Cooperatives. One of the further, and at the same time new, criteria for all organizations and institutions receiving and applying for funds to realize programs of the labor market and vocational trainings is the introduction and certification of the quality management system. The aim of the paper is to compare the activity of Invalids' Cooperatives in Poland and Germany. This aim will be carried out by analyzing the regulations and as far as possible the data available (the regulations became effective in two stages: in April 2012, and since 01.01.2013 onwards). The findings of the article have been collected in the form of a description of the situation and forecast for 2013.
Nonverbal and Verbal Cognitive Discrepancy Profiles in Autism Spectrum Disorders: Influence of Age and Gender
Authors: Ankenman Katy , Elgin Jenna , Sullivan Katherine , Vincent Logan , Bernier Raphael 
Published: January 2014

Abstract
Research suggests that discrepant cognitive abilities are more common in children with autism spectrum disorder (ASD) and may indicate an important ASD endophenotype. The current study examined the frequency of IQ discrepancy profiles (nonverbal IQ &gt; verbal IQ [NVIQ &gt; VIQ], verbal IQ &gt; nonverbal IQ [VIQ &gt; NVIQ], and no split) and the relationship of gender, age, and ASD symptomatology to IQ discrepancy profile in a large sample of children with ASD. The NVIQ &gt; VIQ profile occurred at a higher frequency than expected, had more young males, and showed more autism symptoms than the other groups. Results suggest that the NVIQ &gt; VIQ profile may be less likely to represent a subtype of ASD, but rather a common developmental pathway for children with ASD and other disorders.
The practice of humanities in medicine at Mayo Clinic: Arts and humanities programmes in patient care and medical education
Authors: Rian Johanna 
Published: January 2014

Abstract
‘Humanities in Medicine’ programmes at major teaching hospitals and clinics offer a range of experiences for both patients and medical students. This report from the field discusses the history of the programme, the legacy of the institutional commitment to the interplay of arts and health and specifics of programmes designed for patient and student constituencies. References to existing studies locate the programmes in the context of the national field of activity.
Working in a troubled land: Using the applied arts towards conflict transformation and community health in Israel
Authors: Speiser Vivien Marcow 
Published: January 2014

Abstract
This article will describe teaching philosophies, pedagogical approaches and experiences in community outreach programmes developed by the author and other colleagues within the context of the Lesley University Extension Program in Israel. Studies of conflicts with both children and adults throughout Israel suggest a society permeated by the psychological stress and trauma associated with dislocation, conflict and violence. This article intends to contribute to an understanding of applied arts-based approaches to working with similarities and differences between the self and others in order to build a more tolerant and peaceful culture in Israel. Artists, educators, community workers, mental health counsellors and health professionals need additional tools with which to deal with these psychological issues in order to enable the process of building a more tolerant society and promoting peace. Examples will be drawn from conferences, events and other community outreach activities.
Ne-vé-Shalom/Waa-hat i-sal-aam: Using written stories to heal
Authors: Lieblich Amia 
Published: January 2014

Abstract
A life-story study of the bi-national village Ne-vé Shalom/Waa-hat i-sal-aam was conducted for the purpose of writing a book about the community. In the published book (Lieblich 2012), the individual interviews are written as separate narratives about each of the participants. However, the post-publication reactions of the village members indicated that reading each other’s life stories promoted better understanding and empathy, who struggle with deep tensions, splits and disagreements. Reading the ‘other’s’ life story in private may be a preliminary step before a face-to-face dialogue is possible. This proposition is discussed in the framework of different models of conflict resolution and in reference to the author’s own experience vis-à-vis the community. Thus, the reported study adds to our understanding of the wide healing potential of life stories.
Fetal posterior urethral valve mechanic perforation using an 18-gauge needle: a case-series
Authors: Bertin Martina , Cosmi Erich , Visentin Silvia , Rampon Michela , Gizzo Salvatore 
Published: January 2014

Abstract

Objective: To assess the effectiveness of using an 18-gauge needle inserted through the perineal surface of the fetus to solve magacystis and posterior urethral valve (PUV).

Methods: From February 2008 to January 2012, 15 cases of magacystis were referred to our tertiary referral center, and in ten, PUV was suspected. In the cases where PUV was suspected after a detailed ultrasound scan, women gave consent to proceed with fetal therapy under sonographic guidance using an 18-gauge needle. The procedures lasted for a median time of 30 min (range 15–50 min). The needle was inserted through the perineal surface of the fetus to perforate the dilated posterior ureteral valve, as well as to perform a perineal vescicocentesis.

Results: Median gestational age at time of referral was 17 weeks of gestation (range 16–19 weeks). Five fetuses were female and ten male. Nine cases opted for pregnancy termination, as the kidneys were dysplastic showing hyperechoic structure, while six cases were treated, as the kidneys showed a normal functionality as well as cortico-medullar differentiation. Five fetuses were male and one female. After fetal therapy, there were no stillbirths. All fetuses were delivered at term and the infants were followed up by routine kidney ultrasonography and functionality after a median follow-up of 16 months.

Conclusions: Despite the most commonly used fetal therapy being vesico-amiotic shunting, percutaneous fetal cystoscopy that allows laser valve ablation and mechanical disruption was the procedure used in the present study. This allowed the direct treatment of the urethral obstruction that caused megacystis, without need to repeat the procedure and without the need of any postnatal therapy.
Tertiary formylated amines by microwave irradiation of N,N-dimethyl-N′-(2-pyridyl)formamidines with methyl vinyl ketone
Authors: Gómez-García Omar , Salgado-Zamora Héctor , Campos-Aldrete Elena 
Published: January 2014

Abstract
Treatment of N,N-dimethyl-N′-(2-pyridyl)formamidine with methyl vinyl ketone under microwave irradiation yields N-formyl-N-(3-oxobutyl)-2-pyridylamine without decomposition or polymerization of methyl vinyl ketone. The result is an alternative non-oxidative approach to the preparation of N-formyl-substituted aminoketones.
Umbilical vein volume flow in monochorionic twin pairs at 11–14 weeks
Authors: Zoppi Maria Angelica , Iuculano Ambra , Monni Giovanni 
Published: January 2014

Abstract
We investigated the umbilical vein volume flow (UVVF) at 11–14 weeks in monochorionic-diamniotic (MCDA) twins, focusing on the occurrence of complications. We considered 87 MCDA pregnancies. We used “E-flow” to detect the umbilical vein and measured the mean velocities and diameters of veins, also calculating the UVVF. Pregnancies were divided into four groups: a (twin-to-twin transfusion, TTTS); b (selective intrauterine growth restriction, sIUGR); c (discordance of fluid, DF); and d (with “normal” outcome). The main outcome of the study was the assessment of the difference of UVVF between twin 1 and twin 2 (larger and smaller twin). In eight of eight pairs of group a and seven of seven pairs of group b, the UVVF of fetuses 1 were significantly different than fetuses 2 (P<0.05). The UVVFs of fetuses 2 of group a were significantly lower in respect to the UVVFs of fetuses 2 of group d (P<0.05). We provide evidence of an important difference in UVVF in pairs that successively developed TTTS or sIUGR. The smaller fetuses of group a (TTTS) showed a lower venous return than fetuses 2 of group d (normal). First-trimester UVVF is lower in fetuses with a smaller crown-rump length in twin pairs at risk of TTTS or IUGR.
Prenatal diagnosis of sex chromosome aneuploidies and disorders of sex development – a retrospective analysis of 11-year data
Authors: Vlatkovic Ivanka Bekavac , Hafner Tomislav , Miskovic Berivoj , Vicic Ana , Poljak Borna , Stipoljev Feodora 
Published: January 2014

Abstract

Objective: Analysis of prenatally diagnosed sex chromosome aneuploidies and disorders of sex development (DSDs).

Methods: This study includes a retrospective data analysis of 46 prenatally detected sex chromosome aneuploidies and one case of 46,XY DSD diagnosed during an 11-year period (2002–2012) at our department.

Results: Of the 46 sex chromosome aneuploidies, 29 cases (63.0%) were in the group of a selected population of women according to abnormal first-/second-trimester ultrasound and 17 (37.0%) cases in an unselected population of women who underwent fetal karyotyping because of advanced maternal age. The most common aneuploidy was Turner syndrome in full and mosaic form (50%). Complete androgen insensitivity syndrome was diagnosed in the case of 46,XY DSD.

Conclusions: Sex chromosome aneuploidies must be taken into consideration if, in the first or second trimester, abnormalities are revealed on ultrasound, mainly Turner syndrome in full or mosaic form and 47,XYY.
Synthesis and characterization of a series of novel amino β-cyclodextrin-conjugated poly(ε-lysine) derivatives
Authors: Jiang Rui-Jian , Yang Bo , Yi Dong , Wang Fen , Han Bin , Zhao Yu-Lin , Liao Xia-Li , Yang Jian , Gao Chuan-Zhu 
Published: January 2014

Abstract
Soluble poly(ε-lysine)s bearing β-cyclodextrin (β-CD) moieties were prepared by three amino β-CD derivatives and N-succinylated poly(ε-lysine), in which the poly(ε-lysine) and amino β-CD derivatives were bonded covalently to the end carboxyl groups of succinic acid by peptide bonds. 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI) and N-hydroxysuccinimide (NHS) were chosen to assist the reaction. The three poly(ε-lysine) derivatives were characterized by 1H nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FT-IR). The synthesis process is simple, feasible and has strong practicability. The target polymers can serve as new polymer biomaterial for use in the biotechnology area.
New insight into Eu(III) sorption mechanism at alumina/water interface
by batch technique and EXAFS analysis
Authors: Yang S. T. , Zong P. F. , Sheng G. D. , Ren X. M. , Huang Y. Y. , Wang X. K. 
Published: January 2014

Abstract
In this study, the interactions among Eu(III), humic acid (HA) and γ-Al2O3 as a function of pH and ionic
strength were investigated by batch technique and extended X-ray absorption fine structure (EXAFS) analysis. For binary γ-Al2O3/Eu(III) systems, the pH-dependent and ionic strength-independent sorption behavior was indicative of an inner-sphere
complexation mechanism. The EXAFS spectra analysis showed that Eu(III) sorption mechanisms at pH 5.0, 6.5 and 8.0 could be attributed
to the formation of edge-shared and corner-shared surface complexes. In contrast, surface precipitation and/or surface polymerization
tended to be the predominant sorption mechanism at pH 10.0. The spectra analysis results suggested no difference between the
proportions of edge-shared and corner-shared complexes formed at different ionic strengths. For ternary γ-Al2O3/HA/Eu(III) systems, the sorption percentage of Eu(III) increased with increasing ionic strength. The EXAFS-derived
structural parameters pointed to the formation of binary surface complexes (i.e., edge-shared mode and corner-shared mode) at
low ionic strength and ligand-bridging ternary complexes at high ionic strength. In addition, the stoichiometry of ternary complexes
showed a trend from 1:1 form (i.e., γ-Al2O3/L/Eu(III), L represents HA sites) to 1:2 form (i.e.,
γ-Al2O3/L2/Eu(III), L represents HA sites) with increasing ionic strength. The experimental findings in this
study can provide an important theoretical basis for further predicting the
fate of trivalent radionuclides in aquatic systems.