bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution, habitat associations and status of the Carpentarian Pseudantechinus (Pseudantechinus mimulus, Dasyuridae)
Authors: Barnes Jarrad C. , Clemente Christofer J. , Brunton Elizabeth A. , Sanders Mark G. , Burnett Scott E. 
Published: July 2024

AbstractThe Carpentarian Pseudantechinus (Pseudantechinus mimulus, Dasyuridae) is a little‐known, saxicolous dasyurid marsupial from the Mount Isa Inlier bioregion in Queensland (QLD) and the Gulf Coastal bioregion in the Northern Territory (NT), Australia. A paucity of targeted survey effort across broad swathes of potentially suitable habitat means that the species' distribution and habitat associations are uncertain. This study aimed to (1) refine the contemporary distribution of P. mimulus, (2) determine the landscape and floristic variables that may predict P. mimulus presence, and (3) assess the current conservation status of P. mimulus. We conducted camera trap surveys covering 631 camera stations at 227 independent sites over 4 years for a total of 28 767 trap‐nights throughout QLD and NT in known and predicted suitable habitat. Stepwise generalized linear models were used to test the effect of landscape and floristic predictors on P. mimulus presence. The species' contemporary distribution was assessed using a MAXENT species distribution model. We collated a database of 292 records of P. mimulus, including 111 recorded during this study, extending the species' known range in QLD. The proposed holotype location of the Mittiebah Range was surveyed twice during this study but P. mimulus was not recorded. Pseudantechinus mimulus had the highest probability of presence on most non‐northerly aspects on metamorphic landforms. Eleven plant taxa had a significant effect on P. mimulus presence. This study provides new evidence for landscape and floristic factors that help predict the presence of P. mimulus. Our results indicate the possibility of two disjunct populations, but large swathes of potential habitat still require additional effort to determine the species' true distribution. Our estimate for area of occupancy partially satisfies a threatened species listing; however, more focused research on population dynamics, trends in habitat quality, and landscape‐scale threats is necessary.
Shaming, stringency, and shirking: Evidence from food‐safety inspections
Authors: Bovay John 
Published: July 2024

AbstractThis paper examines the responses of chicken producers to public disclosure of quality information (or categorization) regarding Salmonella in chicken carcasses. Producers exert effort to attain better categorization and shirk when failing to meet the thresholds required for better categorization. Public disclosure reduces this shirking effect. However, some producers shirk even under public disclosure when the threshold for disclosure is too stringent. The results suggest that the most effective quality disclosure policies would either disclose continuous (noncategorical) information or impose fines or other sanctions on producers attaining the poorest quality.
Diabetes in residential aged care: Pharmacological management and concordance with clinical guidelines
Authors: Bhalla Hargun , Huang Guogui , Seaman Karla , Silva S. Sandun Malpriya , Wu Bosco , Wabe Nasir , Westbrook Johanna I. , Nguyen Amy D. 
Published: July 2024

AbstractObjectiveExisting studies have highlighted suboptimal diabetes management in residential aged care facilities (RACFs). However, understanding of diabetes management in Australian metropolitan RACFs has been limited. This retrospective cohort study aimed to explore the pharmacological management of diabetes in 25 RACFs in Sydney Australia and assess concordance with clinical practice guidelines (CPGs).MethodsData from 231 permanent RACF residents aged ≥65 years and over with type 2 diabetes mellitus over the period from 1 July 2016 to 31 December 2019 were used. Concordance was measured by assessing the medications and medical history data for each individual resident for concordance with evidence‐based CPGs. Multivariable logistic regression was used to estimate the effect of resident characteristics on concordance with CPGs.ResultsOf the 231 residents with diabetes, 87 (38%) were not taking any antidiabetic medication. Pharmacological management inconsistent with CPG recommendations was observed for 73 (32%) residents, with the most common reason for non‐concordance being the use of medications with significant adverse effects in older adults (47, 2%). Residents with hypertension or other heart diseases in addition to their diabetes had greater odds of their diabetes management being non‐concordant with CPGs (OR = 2.84 95% CI = 1.54, 5.3 and OR = 2.64, 95% CI = 1.07, 6.41, respectively).ConclusionsPharmacological diabetes management in metropolitan Australian RACFs is suboptimal, with a high prevalence of inconsistency with CPGs (32%) observed. Additionally, having hypertension or heart diseases significantly increased the possibility of non‐concordance among diabetic RACF residents. Further investigation into the underlying relationships with comorbidities is required to develop better strategies.
Revealing Properties of Citizenship through Landscape: Enacting “Block 16” through Dispossession and Displacement
Authors: Przybylinski Stephen 
Published: July 2024

AbstractThis paper examines the relationship between property and citizenship by engaging in a genealogy of one property in Portland, Oregon, “Block 16”, which details how this property was first enacted and then maintained into the 21st century. The paper foregrounds how normative definitions of liberal subjectivity were applied to Indigenous peoples originally living on this land, as well as valuations of citizenship for marginalised renters and the residents of a homeless encampment “illegally” occupying this property, to justify the dispossession and displacement of the groups using this same plot of land over time. I argue that the spatial enactment and maintenance of private property is contingent upon producing political subjects demarcated as “improper”, deviants from the normative or ideal liberal subject and citizen. To highlight how property shapes propriety, the paper engages in landscape analysis to reveal how the social relations producing land as property rely upon representations of impropriety and moral deficit to maintain the ownership model of private property against the historical use values of the land.
Risk factors for uveitis in a Finnish sarcoid population
Authors: Joukainen Elli , Antonen Jaakko , Leinonen Sanna 
Published: July 2024

AbstractPurposeTo evaluate possible risk factors for uveitis among Finnish sarcoidosis patients.MethodsPatient charts of patients with sarcoidosis, with (n = 97) or without (n = 255) uveitis, and with a comprehensive eye examination from January 2014 to January 2021 at Tays Eye Centre, Tampere University Hospital, Finland were studied.ResultsSarcoidosis patients with uveitis had higher rate of lymphocytopenia (43% vs. 29%, p = 0.041) and lower serum lysozyme levels (2.0 mg/L vs. 2.3 mg/L, p = 0.049; 95% CI, −0.692 to −0.002). Lysozyme level or lymphocytopenia did not have a statistically significant effect on the probability of uveitis in a binary logistic regression analysis. No other differences in the potential risk factors with p‐values ≤0.05 were found, including bilateral hilar lymphadenopathy, serum angiotensin‐converting enzyme (ACE) levels, sex, age and history of smoking.ConclusionLymphocytopenia and lower serum lysozyme levels present as possible risk factors for uveitis among patients with sarcoidosis. Systematic measurement of lymphocyte and lysozyme levels in sarcoidosis is needed to further understand their role as potential risk factors.
Letter: Helicobacter pylori and metabolic syndrome‐related von Willebrand factor and plasminogen activator inhibitor‐1 activity levels for outcome prediction of advanced chronic liver disease: Authors' reply
Authors: Scheiner Bernhard , Dominik Nina , Mandorfer Mattias 
Published: July 2024

LINKED CONTENTThis article is linked to Dominik et al papers. To view these articles, visit https://doi.org/10.1111/apt.17945 and https://doi.org/10.1111/apt.18066
Unmasking luxury consumption and its psychology: An experimental approach to understanding the motivations behind ethical and sustainable brand preferences
Authors: Islam Tahir , Arya Vikas , Bodla Ali Ahmad , Palladino Rosa , Papa Armando 
Published: July 2024

AbstractThis research delved into the dynamics between pride, sustainability detectability, and product consciousness through three experimental studies conducted among Chinese millennials focusing on lavish brand. Grounded in the positive emotions theory, this study sought to discern the circumstances in which individuals with materialistic tendencies exhibit willingness to engage with sustainable luxury brands. The results of this meticulous experimental design indicate a positive relationship between materialism and the intention to purchase sustainable luxury brands, with pride identified as a mediating factor, and discussed the involvement of high conspicuousness of the product in the context of detectability of the brand's sustainability. Furthermore, this study offers insights through the positive emotion theory and examining the impact of self‐conscious emotions on buyer preferences regarding sustainable luxury brands. The findings from this theoretical research provide valuable insights for brand managers, scholars, and policymakers aiming to develop sustainable brands that resonate with the sentiments and values of conscientious consumers.
A 2‐year prospective evaluation of the Prostate Health Index in guiding biopsy decisions in a large cohort
Authors: Chiu Peter Ka‐Fung , Liu Alex Qinyang , Lau Sui‐Yan , Teoh Jeremy Yuen‐Chun , Ho Chi‐Chun , Yee Chi‐Hang , Hou See‐Ming , Chan Chi‐Kwok , Tang Wai‐Lun , Bangma Chris H. , Chu Peggy Sau‐Kwan , Poon Wing‐Tat , Ng Chi‐Fai , Roobol Monique J. 
Published: July 2024

ObjectivesTo prospectively evaluate how the Prostate Health Index (PHI) impacts on clinical decision in a real‐life setting for men with a prostate‐specific antigen (PSA) level between 4 and 10 ng/mL and normal digital rectal examination.Patients and MethodsSince 2016, the PHI has been available at no cost to eligible men in all Hong Kong public hospitals. All eligible patients who received PHI testing in all public Urology units (n = 16) in Hong Kong between May 2016 and August 2017 were prospectively included and followed up. All included men had a PHI test, with its result and implications explained; the subsequent follow‐up plan was then decided via shared decision‐making with urologists. Patients were followed up for 2 years, with outcomes including prostate biopsy rates and biopsy findings analysed in relation to the initial PHI measurements.ResultsA total of 2828 patients were followed up for 2 years. The majority (82%) had PHI results in the lower risk range (score <35). Knowing the PHI findings, 83% of the patients with elevated PSA decided not to undergo biopsy. In all, 11% and 45% opted for biopsy in the PHI score <35 and ≥35 groups, respectively. The initial detection rate of International Society of Urological Pathology (ISUP) Grade Group (GG) ≥2 cancer was higher in the PHI score ≥35 group (23%) than in the PHI score <35 group (7.9%). Amongst patients with no initial positive biopsy findings, the subsequent positive biopsy rate for ISUP GG ≥2 cancer was higher in the PHI score ≥35 group (34%) than the PHI score <35 group (13%) with a median follow‐up of 2.4 years.ConclusionIn a real‐life setting, with the PHI incorporated into the routine clinical pathway, 83% of the patients with elevated PSA level decided not to undergo prostate biopsy. The PHI pathway also improved the high‐grade prostate cancer detection rate when compared to PSA‐driven strategies. Higher baseline PHI predicted subsequent biopsy outcome at 2 years. The PHI can serve as a tool to individualise biopsy decisions and frequency of follow‐up visits.
FOXM1 transcriptional regulation
Authors: Li Mengxi , Gao Xuzheng , Su Yanting , Shan Shigang , Qian Wenbin , Zhang Zhenwang , Zhu Dan 
Published: July 2024

AbstractFOXM1 is a key transcriptional regulator involved in various biological processes in mammals, including carbohydrate and lipid metabolism, aging, immune regulation, development, and disease. Early studies have shown that FOXM1 acts as an oncogene by regulating cell proliferation, cell cycle, migration, metastasis, and apoptosis, as well as genes related to diagnosis, treatment, chemotherapy resistance, and prognosis. Researchers are increasingly focusing on FOXM1 functions in tumor microenvironment, epigenetics, and immune infiltration. However, researchers have not comprehensively described FOXM1's involvement in tumor microenvironment shaping, epigenetics, and immune cell infiltration. Here we review the role of FOXM1 in the formation and development of malignant tumors, and we will provide a comprehensive summary of the role of FOXM1 in transcriptional regulation, interacting proteins, tumor microenvironment, epigenetics, and immune infiltration, and suggest areas for further research.
Spexin inhibits excessive autophagy‐induced ferroptosis to alleviate doxorubicin‐induced cardiotoxicity by upregulating Beclin 1
Authors: Ou Wen , Liu Haiqiong , Chen Changhai , Yang Chaobo , Zhao Xiaoqing , Zhang Yu , Zhang Zhiyin , Huang Shuwen , Mo Huaqiang , Lu Weizhe , Wang Xianbao , Chen Aihua , Yan Jing , Song Xudong 
Published: July 2024

AbstractBackground and PurposeDoxorubicin is widely used in the treatment of malignant tumours, but doxorubicin‐induced cardiotoxicity severely limits its clinical application. Spexin is a neuropeptide that acts as a novel biomarker in cardiovascular disease. However, the effects of spexin on doxorubicin‐induced cardiotoxicity is unclear.Experimental ApproachWe established a model of doxorubicin‐induced cardiotoxicity both in vivo and in vitro. Levels of cardiac damage in mice was assessed through cardiac function assessment, determination of serum cardiac troponin T and CKMB levels and histological examination. CCK8 and PI staining were used to assess the doxorubicin‐induced toxicity in cultures of cardiomyocytes in vitro. Ferroptosis was assessed using FerroOrange staining, determination of MDA and 4‐HNE content and ferroptosis‐associated proteins SLC7A11 and GPX4. Mitochondrial membrane potential and lipid peroxidation levels were measured using TMRE and C11‐BODIPY 581/591 probes, respectively. Myocardial autophagy was assessed by expression of P62 and Beclin1.Key ResultsSpexin treatment improved heart function of mice with doxorubicin‐induced cardiotoxicity, and attenuated doxorubicin‐induced cardiotoxicity by decreasing iron accumulation, abnormal lipid metabolism and inhibiting ferroptosis. Interestingly, doxorubicin caused excessive autophagy in cardiomyocyte in culture, which could be alleviated by treatment with spexin. Knockdown of Beclin 1 eliminated the protective effects of spexin in mice with DIC.Conclusion and ImplicationsSpexin ameliorated doxorubicin‐induced cardiotoxicity by inhibiting excessive autophagy‐induced ferroptosis, suggesting that spexin could be a drug candidate against doxorubicin‐induced cardiotoxicity. Beclin 1 might be critical in mediating the protective effect of spexin against doxorubicin‐induced cardiotoxicity.
Effect of depression and the antidepressant fluoxetine on osseointegration—A pre‐clinical in vivo experimental study
Authors: Xiaowen Yundeng , Zhu Jingxuan , Gong Mingming , Meng Ge , Tan Renran , Zhang Yanbing , Chen Zhiyu 
Published: July 2024

AbstractObjectiveThe aim of this study was to explore the effect of depression and selective serotonin reuptake inhibitors on implant osseointegration and bone healing.MethodsForty‐eight 6‐ to 8‐week‐old SPF Sprague–Dawley male rats were randomly divided into four groups: the Control group, the Fluoxetine group, the Depression group and the De&Flu group. The rats in the Depression group and the De&Flu group were subjected to a depression modelling process, and the rats in the Control group and the Fluoxetine group were raised normally. Then, a titanium implant was placed in the right tibia of each rat. In the Fluoxetine group and De&Flu group, fluoxetine was injected subcutaneously daily, while subcutaneously injecting physiological saline in the Control group and Depression group. Collecting serum from the rats used for ELISA. The surgical area was cut for microcomputed tomography and histology observation.ResultsAfter 12 weeks, bone mineral density was lower in the De&Flu group than in the Control group, Depression group and Fluoxetine group. Bone mineral density was also lower in the Depression group and the Fluoxetine group than in the Control group. The percentage of bone–implant contact (BIC%) in De&Flu rats was lower than in the Control, Depression and Fluoxetine groups. The BIC% in the Depression group and the Fluoxetine group was lower than in the Control group.ConclusionsDepression and fluoxetine negatively affect bone density and implant osseointegration independently, and this damaging effect is exacerbated when both factors are present. The mechanism may be related to the dysregulation of the hypothalamic–pituitary–adrenal axis and inflammation in the body.
Sex differences in PD‐L1‐induced analgesia in paclitaxel‐induced peripheral neuropathy mice depend on TRPV1‐based inhibition of CGRP
Authors: Cao Yan , Jiang Wenqi , Yan Fang , Pan Yuyan , Gei Liba , Lu Simin , Chen Xiangnan , Huang Yang , Yan Yan , Feng Yan , Li Qiang , Zeng Weian , Xing Wei , Chen Dongtai 
Published: July 2024

AbstractAimsPaclitaxel (PTX) is extensively utilized in the management of diverse solid tumors, frequently resulting in paclitaxel‐induced peripheral neuropathy (PIPN). The present study aimed to investigate sex differences in the behavioral manifestations and underlying pathogenesis of PIPN and search for clinically efficacious interventions.MethodsMale and female C57BL/6 mice (5–6 weeks and 12 months, weighing 18–30 g) were intraperitoneally (i.p.) administered paclitaxel diluted in saline (NaCl 0.9%) at a dose of 2 mg/kg every other day for a total of 4 injections. Von Frey and hot plate tests were performed before and after administration to confirm the successful establishment of the PIPN model and also to evaluate the pain of PIPN and the analgesic effect of PD‐L1. On day 14 after PTX administration, PD‐L1 protein (10 ng/pc) was injected into the PIPN via the intrathecal (i.t.) route. To knock down TRPV1 in the spinal cord, adeno‐associated virus 9 (AAV9)‐Trpv1‐RNAi (5 μL, 1 × 1013 vg/mL) was slowly injected via the i.t. route. Four weeks after AAV9 delivery, the downregulation of TRPV1 expression was verified by immunofluorescence staining and Western blotting. The levels of PD‐L1, TRPV1 and CGRP were measured via Western blotting, RT–PCR, and immunofluorescence staining. The levels of TNF‐α and IL‐1β were measured via RT–PCR.ResultsTRPV1 and CGRP protein and mRNA levels were higher in the spinal cords of control female mice than in those of control male mice. PTX‐induced nociceptive behaviors in female PIPN mice were greater than those in male PIPN mice, as indicated by increased expression of TRPV1 and CGRP. The analgesic effects of PD‐L1 on mechanical hyperalgesia and thermal sensitivity were significantly greater in female mice than in male mice, with calculated relative therapeutic levels increasing by approximately 2.717‐fold and 2.303‐fold, respectively. PD‐L1 and CGRP were partly co‐localized with TRPV1 in the dorsal horn of the mouse spinal cord. The analgesic effect of PD‐L1 in PIPN mice was observed to be mediated through the downregulation of TRPV1 and CGRP expression following AAV9‐mediated spinal cord specific decreased TRPV1 expression.ConclusionsPTX‐induced nociceptive behaviors and the analgesic effect of PD‐L1 in PIPN mice were sexually dimorphic, highlighting the significance of incorporating sex as a crucial biological factor in forthcoming mechanistic studies of PIPN and providing insights for potential sex‐specific therapeutic approaches.
The diverse socioeconomic contributions of wildlife ranching
Authors: Denner Candice , Clements Hayley S. , Child Matthew F. , De Vos Alta 
Published: July 2024

AbstractThe expansion of wildlife ranching has been broadly linked to conservation benefits, job creation, and economic contributions. However, a more nuanced understanding of the socioeconomic contributions of wildlife ranching accounting for the enterprise diversity in the sector remains a major limitation to assessing its potential to contribute to sustainable development. We assessed several important socioeconomic contributions of diverse wildlife‐based business models, defined by their main revenue‐generating activities, within the South African wildlife ranching industry, and the financial viability of these models. Owners and managers of privately‐owned wildlife ranches and conventional agricultural farms (for comparative purposes) were interviewed in the Eastern Cape (112 ranches; 24 farms) and Limpopo provinces (152 ranches; 4 farms). We used a hierarchical clustering analysis to delineate six wildlife ranching business models. These included three more specialized models: ecotourism, trophy hunting, and wildlife breeding, and three more mixed models: mixed hunting (i.e., both meat and trophy hunting), mixed wildlife‐agriculture, and trophy hunting‐game meat. In general, ecotourism‐focused ranches employed more people in total and per hectare (median = 23 jobs; 0.008/ha), and a higher proportion of women and skilled employees (41% and 45% of employees, respectively) than the other ranching models (median = 7–21 jobs; 0.002–0.005/ha) and conventional agriculture (median = 12 jobs; 0.004/ha). Trophy hunting‐focused ranches employed the second highest number of people per hectare (0.006) although on average, a third of these jobs were seasonal. Trophy hunting ranches tended to be more profitable (median profit margin = 33%) than ecotourism (−10%), wildlife breeding (0%) and mixed‐hunting (12%) ranches, though ecotourism ranches showed very high variability (interquartile range = −32% to 14%). These findings advance our understanding of the distinct socioeconomic contributions of diverse wildlife ranches, which benefits policy discourse and implementation surrounding the industry, promoting improved industry sustainability and inclusive growth.