bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Presurgical Orthodontic Treatment on the Outcome of Secondary Bone Graft for Individuals With Cleft Lip and Palate
Authors: Fu Moyu Lara , Aldosari Malak , Chakraborty Archak , Ko Jaemin , Tahir Peggy , Oberoi Snehlata 
Published: July 2024

Background/Objective:
Alveolar bone graft (ABG) or repair has become a routine part of treatment protocols for individuals with cleft lip and/or palate. However, the necessity and potential benefits of presurgical orthodontic treatment in influencing the outcomes of secondary alveolar bone grafting remain inconclusive. This systematic review aimed to assess the impact of presurgical orthodontics on preparing patients for secondary alveolar bone grafts.

Study Design:
The authors systematically searched for relevant articles in PubMed, Web of Science, and Embase databases spanning the period from January 1, 2000, to December 31, 2023, using keywords related to alveolar bone grafting and orthodontic treatment for patients with cleft lip and/or palate. The review encompassed various study designs, including prospective and retrospective studies, observational studies, cross-sectional studies, randomized and nonrandomized clinical trials, cohort studies, and case-control studies. The review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and the risk of bias was evaluated in studies selected for full-text review.

Results:
The search strategy identified 809 publications. After initial screening and application of exclusion criteria, 11 studies were included for final review. Three were prospective studies, 8 were retrospective studies, and 3 were cross-sectional cohort studies. On the basis of ROBINS-I and RoB 2 risk assessment, 9 studies were found to be of moderate risk of bias, one study was categorized as of high risk of bias, and 1 study was categorized as low risk of bias.

Conclusions:
Drawing from the latest and most reliable studies, 7 out of 11 included studies provided compelling evidence that presurgical orthodontics preceding alveolar bone grafting (ABG) leads to significantly improved outcomes compared with cases without presurgical orthodontic intervention. Notably, individuals with specific conditions, such as severely collapsed upper arch and mispositioned upper incisors, appear to derive the greatest benefits from presurgical orthodontic treatment. However, a call for additional studies characterized by high methodological quality and with longer follow-up periods is emphasized to enhance the safety considerations for both practitioners and patients concerning the utilization of presurgical orthodontics in the treatment of individuals with cleft lip and palate.
The Applicability of Polyetheretherketone and Titanium Mesh in Cranioplasty: A Retrospective Comparative Analysis
Authors: Peng Yao-Nan , Liu Zhen-Zhen , Qiao Liang 
Published: July 2024

Objective:
To compare the clinical application effect and safety of polyetheretherketone (PEEK) and titanium mesh (TM) in cranioplasty.

Methods:
Four-year retrospective comparison of patients (96 cases) undergoing synthetic cranioplasty with PEEK or TM. The patients were divided into the PEEK group (24 cases) and the TM group (72 cases) according to the implants, and the patient demographics, general conditions before the operation, postoperative complications, length of postoperative hospital stay, total costs, satisfaction with shaping and long-term complications were compared between the 2 groups.

Results:
Patients in the PEEK group were younger than those in the TM group (P=0.019). Hospitalization costs were significantly higher in the PEEK group than in the TM group (P<0.001). The incidence of postoperative subcutaneous effusion was 33% in the PEEK group and 6.9% in the TM group, which suggests that patients in the PEEK group had a higher risk of postoperative subcutaneous effusion (P=0.001). There was no significant difference in the incidence of long-term complications and cosmetic satisfaction between the 2 groups at 4 years postoperatively.

Conclusions:
In this study, both titanium mesh and PEEK are reliable implants for cranioplasty. Titanium mesh is widely used in cranioplasty due to its cost-effective performance. PEEK has gradually gained recognition due to the characteristics of the material and surgical procedure, but the price needs to be further reduced, and attention should be paid to the occurrence and treatment of early postoperative subcutaneous effusion.
Maryland’s Global Budget Revenue Payment Model and Shifts in the Surgical Site of Care Among Medicare Beneficiaries
Authors: Lin Yu-Li , Herring Bradley , Melamed Alexander , Hassan Abbas M. , Petrillo Laura A. , Keating Nancy L. , Offodile Anaeze C. 
Published: July 2024

Objective:
To assess the association between the Global Budget Revenue (GBR) payment model and shifts to the outpatient setting for surgical procedures among Medicare fee-for-service beneficiaries in Maryland versus control states.

Summary Background Data:
The GBR model provides fixed global payments to hospitals to reduce spending growth and incentivize hospitals to reduce the costs of care while improving care quality. Since surgical care is a major contributor to hospital spending, the GBR model might accelerate the ongoing shift from the inpatient to the outpatient setting to generate additional savings.

Methods:
A difference-in-differences (DiD) design was used to compare changes in surgical care settings over time from pre-GBR (2011-2013) to post-GBR (2014-2018) for Maryland versus control states for common surgeries that could be performed in the outpatient setting. A cross-sectional approach was used to compare the difference in care settings in 2018 for total knee arthroplasty which was on Medicare’s Inpatient-Only List before then.

Results:
We studied 47,542 surgical procedures from 44,410 beneficiaries in Maryland and control states. GBR’s 2014 implementation was associated with an acceleration in the shift from inpatient to outpatient settings for surgical procedures in Maryland (DiD: 3.9 percentage points, 95% CI: 2.3, 5.4). Among patients undergoing total knee arthroplasty in 2018, the proportion of outpatient surgeries in Maryland was substantially higher than that in control states (difference: 27.6 percentage points, 95% CI: 25.6, 29.6).

Conclusions:
Implementing Maryland’s GBR payment model was associated with an acceleration in the shift from inpatient to outpatient hospital settings for surgical procedures.
Infiltration of Common Myeloid Progenitor (CMP) Cells is Associated With Less Aggressive Tumor Biology, Lower Risk of Brain Metastasis, Better Response to Immunotherapy, and Higher Patient Survival in Breast Cancer
Authors: Oshi Masanori , Wu Rongrong , Khoury Thaer , Gandhi Shipra , Yan Li , Yamada Akimitsu , Ishikawa Takashi , Endo Itaru , Takabe Kazuaki 
Published: July 2024

Objective:
To investigate the clinical relevance of common myeloid progenitor (CMP) cells in breast tumor microenvironment (TME).

Background:
The role of rare cells in TME is less studied. In Silico transcriptomic analyses of real-world data enable us to detect and quantify rare cells, including CMP cells.

Methods:
A total of 5176 breast cancer (BC) patients from SCAN-B, METABRIC, and 5 single-cell sequence cohorts were analyzed using the xCell algorithm. The high group was defined as more than two-thirds of the CMP scores in each cohort.

Results:
CMP cells consist of 0.07% to 0.25% of bulk breast tumor cells, more in estrogen receptor-positive (ER+) compared with triple-negative (TN) subtype (0.1% to 0.75%, 0.18% to 0.33% of immune cells, respectively). CMP cells did not correlate with any of the myeloid lineages or stem cells in TME. CMP infiltration was higher in smaller tumors, with lower Nottingham grade, and in ER+/HER2− than in TNBC consistently in both SCAN-B and METABRIC cohorts. High CMP was significantly associated with a lower risk of brain metastasis and with better survival, particularly in ER+/HER2−. High CMP enriched epithelial-to-mesenchymal transition and angiogenesis pathways, and less cell proliferation and DNA repair gene sets. High CMP ER+/HER2- was associated with less immune cell infiltration and cytolytic activity (P<0.001). CMP infiltration correlated with neoadjuvant chemoimmunotherapy response for both ER+/HER2- and TNBC in the ISPY-2 cohort (AUC=0.69 and 0.74, respectively).

Conclusions:
CMP in BC is inversely associated with cell proliferation and brain metastasis, better response to immunotherapy, and survival. This is the first to report the clinical relevance of CMP infiltration in BC.
Oxidized ATP Suppresses B Lymphocyte Activity to Attenuate Antibody-mediated Rejection of Kidney Allografts in Mice
Authors: Yu Yi , Bi Zirong , Jiang Qifeng , Huang Shangjin , He Yingzhen , Gai Jingci , Huang Huiting , Liu Longshan , Gao Yifang , Li Xirui , Wang Changxi , Wu Chenglin 
Published: July 2024

Background.
Antibody-mediated rejection (AMR) is a major cause of renal allograft dysfunction and loss. Targeting B cells and/or donor-specific antibody removal using plasma exchange and anti-CD20 antibodies are increasingly used in clinical practice, but the efficacy remains limited. Recent studies suggest that targeting purinergic P2X7 receptor/ATP axis can have profound immune regulatory effects in transplant models, but the mechanisms involved remain incompletely defined.

Methods.
Purified B cells were isolated from the spleen of Balb/C mice and cultured with oxidized ATP at different concentrations. Proliferation and differentiation of B cells were examined. Effects of oxidized ATP were examined in a presensitized animal model where kidney allograft rejection mimics aspects of clinical AMR. Histopathology was assessed at the time of rejection or on day 5 after kidney transplantation. Infiltrating immune cells in renal allografts were detected by flow cytometry.

Results.
Oxidized ATP inhibited B-cell activation and proliferation in vitro, significantly attenuated histological signs of graft injury and prolonged kidney allograft survival. Mechanistically, oxidized ATP inhibited antibody secretion by activated B cells in response to lipopolysaccharide stimulation and markedly suppressed the production of donor-specific antibody in kidney allograft recipients. Oxidized ATP also reduced graft infiltration by other inflammatory cells.

Conclusions.
These findings provide evidence for the involvement of the purinergic P2X7 receptor pathway in AMR and suggest that targeting this pathways may have important clinical implications.
Frailty management in older patients: a best practice implementation project
Authors: Chen Chih Wen , Lee Mei-Chen , Liu Kuei Fen , Lin Li-Ju , Wu Shu-Fang Vivienne 
Published: July 2024

ABSTRACT

Introduction:
Frailty in older adults can lead to a gradual decline in organ function. Without timely diagnosis and intervention, this condition can progress rapidly, increasing the risk of disability and mortality.

Objectives:
The aim of this project was to implement evidence-based practices for managing frailty in the medical ward to prevent disability in older patients.

Methods:
This project was conceptually informed by the JBI Evidence Implementation Framework. This framework uses an audit and feedback approach and a pre- and post-test design to measure baseline compliance, develop implementation strategies responsive to gaps in compliance, and conduct a final evaluation to measure changes in compliance. JBI PACES and JBI GRiP situational analysis software were used to support data collection and implementation planning. Ten audit criteria were used with a sample of 30 patients in a regional teaching hospital in southern Taiwan.

Results:
The baseline audit showed poor compliance, with rates below 30% for all ten audit criteria. Through strategies such as professional training and education, the implementation of evidence-based care guidelines, and interdisciplinary consensus-building, the follow-up audit revealed an increase in compliance to over 90% for each audit criterion.

Conclusions:
Frailty management strategies based on evidence-based audit criteria were implemented and routinely measured. The most effective strategies for improving compliance included the development of a training course, a digitized assessment tool, team meetings, interdisciplinary collaboration, communication, and consensus-building.

Spanish abstract:

http://links.lww.com/IJEBH/A225
A naturalistic study of the efficacy and acceptability of rTMS in treating major depressive disorder in Australian youth
Authors: Miljevic Aleksandra , Hoath Kyle , Leggett Kerry S. , Hennessy Lauren A. , Boax Caitlan A. , Hryniewicki Jaroslaw , Rodger Jennifer 
Published: July 2024

AbstractObjectiveRepetitive transcranial magnetic stimulation (rTMS) is an effective, evidence-based treatment for major depressive disorder (MDD) and is publicly funded in Australia. However, there is no published data to date concerning its use in private TMS service provider clinics in Australia. There is further limited data as to its efficacy and safety in treating MDD in youth populations.MethodsThis retrospective study examined routinely collected data of 46 outpatients aged 17 to 25 years old, who received rTMS treatment for MDD in a private TMS clinic. Primary outcomes measures were the Montgomery-Asberg Depression Rating Scale (MADRS) and the depression subscale of the 21-item Depression, Anxiety and Stress Scale (DASS-21). Secondary measures included the anxiety and stress sub-scales of the DASS-21, a measure of Quality of Life (QoL) Enjoyment and Satisfaction Questionnaire, and the Cognitive Failures Questionnaire (CFQ).ResultsA 4–7-week course of rTMS significantly reduce symptoms of self-reported depression (42.5% response) and clinician-assessed depression (40.7% response). Both anxiety and stress significantly reduced across the course of rTMS treatment and significant improvements to QoL and self-reported cognition were observed. Reported side effects following rTMS in youth included a mild headache and fatigue.ConclusionsThe findings of this naturalistic study suggest that an acute course of rTMS provided in private clinical settings is safe and effective – resulting in similar response rates in youth patients as reported in adult patients. In real world practice, rTMS proves to be a well-tolerated and highly effective intervention for MDD in youth, across diverse clinical settings.Implications and ContributionThe findings of this naturalistic study suggest that in real world practice, rTMS proves to be a well-tolerated and highly effective intervention for treating depression and anxiety in youth (17–25-year-olds), with additional benefits to cognitive symptoms of depression and overall well-being.
CryoViT: Efficient Segmentation of Cryogenic Electron Tomograms with Vision Foundation Models
Authors: Gupte Sanket R. , Hou Cathy , Wu Gong-Her , Galaz-Montoya Jesús G. , Chiu Wah , Yeung-Levy Serena 
Published: July 2024

ABSTRACTCryogenic electron tomography (cryoET) directly visualizes subcellular structures in 3D at the nanometer scale. Quantitative analyses of cryoET data can reveal structural biomarkers of diseases, provide novel mechanistic insights, and inform the effects of treatments on phenotype. However, existing automated annotation approaches primarily focus on localizing molecular features with few methods accurately quantifying complex structures such as organelles. We address this challenge with CryoViT, a paradigm shift from traditional convolutional neural networks that leverages vision transformers to enhance the segmentation of large pleomorphic structures that can occupy almost the entire field of view in high-magnification images, such as mitochondria. CryoViT is powered by a large-scale vision foundation model and overcomes limitations of popular U-Net based methods, particularly when training data are scarce. We demonstrate the efficacy of CryoViT on a large cryoET dataset of neurons differentiated from iPSCs derived from Huntington disease (HD) patients and cultured HD mouse model neurons.
MuCST: restoring and integrating heterogeneous morphology images and spatial transcriptomics data with contrastive learning
Authors: Wang Yu , Ma Xiaoke 
Published: July 2024

AbstractSpatially resolved transcriptomics simultaneously measure the spatial location, histology images, and transcriptional profiles of the same cells or regions in undissociated tissues. Integrative analysis of multi-modal spatially resolved data holds immense potential for understanding the mechanisms of biology. Here we present a flexible multi-modal contrastive learning for the integration of spatially resolved transcriptomics (MuCST), which jointly perform denoising, elimination of heterogeneity, and compatible feature learning. We demonstrate that MuCST robustly and accurately identifies tissue subpopulations from simulated data with various types of perturbations. In cancer-related tissues, MuCST precisely identifies tumor-associated domains, reveals gene biomarkers for tumor regions, and exposes intra-tumoral heterogeneity. We also validate that MuCST is applicable to diverse datasets generated from various platforms, such as STARmap, Visium, and omsFISH for spatial transcriptomics, and hematoxylin and eosin or fluorescence microscopy for images. Overall, MuCST not only facilitates the integration of multi-modal spatially resolved data, but also serves as pre-processing for data restoration (Python software is available athttps://github.com/xkmaxidian/MuCST).
A level adjusted cochlear frequency-to-place map for estimating tonotopic frequency mismatch with a cochlear implant
Authors: Sagi Elad , Svirsky Mario A. 
Published: July 2024

ABSTRACTObjectivesTo provide a level-adjusted correction to the current standard relating anatomical cochlear place to characteristic frequency in humans, and to re-evaluate anatomical frequency mismatch in cochlear implant (CI) recipients considering this correction. It is hypothesized that a level-adjusted place-frequency function may represent a more accurate tonotopic benchmark for CIs in comparison to the current standard.DesignThe present analytical study compiled data from fifteen previous animal studies that reported iso-intensity responses from cochlear structures at different stimulation levels. Extracted outcome measures were characteristic frequencies and centroid-based best frequencies at 70 dB SPL input from 47 specimens spanning a broad range of cochlear locations. A simple relationship was used to transform these measures to human estimates of characteristic and best frequencies, and non-linear regression was applied to these estimates to determine how the standard human place-frequency function should be adjusted to reflect best frequency rather than characteristic frequency. The proposed level-adjusted correction was then compared to average place-frequency positions of commonly used CI devices when programmed with clinical settings.ResultsThe present study showed that the best frequency at 70 dB SPL (BF70) tends to shift away from characteristic frequency (CF). The amount of shift was statistically significant (signed-rank test z = 5.143, p < 0.001), but the amount and direction of shift depended on cochlear location. At cochlear locations up to 600° from the base, BF70 shifted downwards in frequency relative to CF by about 4 semitones on average. Beyond 600° from the base, BF70 shifted upwards in frequency relative to CF by about 6 semitones on average. In terms of spread (90% prediction interval), the amount of shift between CF and BF70 varied from relatively no shift to nearly an octave of shift. With the new level-adjusted frequency-place function, the amount of anatomical frequency mismatch for devices programmed with standard of care settings is less extreme than originally thought, and may be nonexistent for all but the most apical electrodes.ConclusionsThe present study validates the current standard for relating cochlear place to characteristic frequency, and introduces a level-adjusted correction for how best frequency shifts away from characteristic frequency at moderately loud stimulation levels. This correction may represent a more accurate tonotopic reference for CIs. To the extent that it does, its implementation may potentially enhance perceptual accommodation and speech understanding in CI users, thereby improving CI outcomes and contributing to advancements in the programming and clinical management of CIs.
Optimal targeted therapy for multiple cancers based on contrastive Notch signaling networks
Authors: Wakamoto Tamaki , Seirin-Lee Sungrim 
Published: July 2024

AbstractOver decades, cancer understanding has advanced significantly at molecular and cellular levels, leading to various therapies based on intra-/inter-cellular networks. Despite this, cancer still remains a leading cause of death globally. The primary driver of cancer mortality is metastasis, responsible for about 90% of cancer deaths, due to unclear pathophysiological mechanisms that complicate treatment development. The Notch signaling pathway, a crucial intercellular network in many cancers, has been extensively studied and therapies targeting the Notch pathway also have been well-studied based on inhibiting various stages of Notch activation. On the other hand, Notch signaling’s role varies between cancers; for instance, in non-small cell lung cancer, Notch1 and Notch2 have opposing effects compared to their roles in embryonal brain tumors. In this study, we assumed a scenario of multiple cancers with contrasting Notch signaling pathways and explored optimal targeted therapies for reducing cancer cells by developing two mathematical models with contrasting Notch signaling pathways. The proposed therapies were compared with existing ones, and strategies were investigated to reduce cancer cell numbers for different stage of cancer. We found that that multiple cancers with contrasting Notch networks can be controlled by a common targeted signal network. Combination therapy enhancing Notch production may be most effective in early-stage cancer, while cleavage therapies may be more effective in late-stage cancer. Our study also suggests that optimal treatment should consider the cancer stage, with careful selection and ordering of medication therapies.