bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute Parameters of Detached Binaries in the Southern Sky – I: V349 Ara and V4403 Sgr
Authors: Erdem A. , Sürgit D. , Engelbrecht C. A. , Van Heerden H. P. 
Published: July 2015

AbstractWe present the first analysis of spectroscopic and photometric observations of the two southern eclipsing binary stars, V349 Ara and V4403 Sgr. Radial velocity curves of these two systems obtained at the South African Astronomical Observatory and their V light curves from the All Sky Automated Survey were solved simultaneously using the Wilson–Devinney code. Our photometric models describe these two systems as Algol-like binary stars with detached configurations. The masses and radii were found to be 2.59 ± 0.07 M⊙, 3.60 ± 0.07 R⊙ and 2.51 ± 0.06 M⊙, 4.15 ± 0.07 R⊙ for the primary and secondary components of V349 Ara, respectively. Those of V4403 Sgr were derived to be 1.33 ± 0.02 M⊙, 1.74 ± 0.02 R⊙ and 1.59 ± 0.03 M⊙, 2.50 ± 0.03 R⊙ for the primary and secondary components, respectively. The distances to V349 Ara and V4403 Sgr were computed to be 677 ± 36 and 199 ± 10 pc from the dynamic parallax, respectively, taking into account interstellar extinction. The evolution cases of these two systems are also examined. Both components of these two systems are evolved main-sequence stars, and the dynamic ages were estimated as approximately 0.67 and 2.29 Gyr for V349 Ara and V4403 Sgr, respectively, when compared to Geneva theoretical evolution models.
On the continuation of solutions of non-autonomous semilinear parabolic problems
Authors: Carvalho Alexandre N. , Cholewa Jan W. , Nascimento Marcelo J. D. 
Published: July 2015

AbstractWe study non-autonomous parabolic equations with critical exponents in a scale of Banach spaces Eσ, σ ∈ [0,1 + μ). We consider a suitable E1+ε-solution and describe continuation properties of the solution. This concerns both a situation when the solution can be continued as an E1+ε-solution and a situation when the E1+ε-norm of the solution blows up, in which case a piecewise E1+ε-solution is constructed.
Impact of water deficit on light interception, radiation use efficiency and leaf area index in a potato crop (Solanum tuberosumL.)
Authors: CAMARGO D. C. , MONTOYA F. , MORENO M. A. , ORTEGA J. F. , CÓRCOLES J. I. 
Published: July 2015

SUMMARYThe aim of the current research was to analyse the effect of four water irrigation treatments (1·20, 1·00, 0·80 and 0·60 of the crop water requirement) on the relationships among leaf area index (LAI), radiation use efficiency (RUE) and green canopy cover in a potato crop (Solanum tuberosumL.) cv. Agria. The crop was established in a commercial plot irrigated with a centre pivot system in Southeast Spain during the 2011 and 2012 seasons. In both seasons, the highest light absorption efficiency values occurred at the LAI value of 3 that corresponded to maximum ground cover. With regard to the irrigation treatment, a significant linear response was indicated for RUE. The results indicate that the 1·00 irrigation treatment produced the best result, improving water resources management without reducing crop yield.
Role of cyclins D1 and D3 in vestibular schwannoma
Authors: Jabbour J , Earls P , Biggs N , Gracie G , Fagan P , Bova R 
Published: July 2015

AbstractBackground:Vestibular schwannomas in younger patients have been observed to be larger in size and grow more quickly.Objective:This study aimed to evaluate the expression of three important cell cycle proteins, cyclin D1, cyclin D3and Ki-67, in vestibular schwannoma patients separated into two age groups: ≤40 years or >40 years.Method:Immunohistochemical detection of cyclin D1, cyclin D3and Ki-67 was undertaken in 180 surgically resected vestibular schwannomas.Results:The proliferation index of vestibular schwannomas was statistically higher in the ≤40 years age group compared to that in the >40 years age group (mean of 4.52vs3.27, respectively;p = 0.01). Overexpression of cyclin D1and cyclin D3was found in 68 per cent and 44 per cent of tumours, respectively.Conclusion:There was an increased Ki-67 proliferation index in the younger age group that appears to correlate with clinical behaviour. Vestibular schwannomas in both age groups show increased expression of cyclin D1and cyclin D3.
A member of the HSP90 family from ovineBabesiain China: molecular characterization, phylogenetic analysis and antigenicity
Authors: GUAN GUIQUAN , LIU JUNLONG , LIU AIHONG , LI YOUQUAN , NIU QINGLI , GAO JINLIANG , LUO JIANXUN , CHAUVIN ALAIN , YIN HONG , MOREAU EMMANUELLE 
Published: July 2015

SUMMARYHeat shock protein 90 (HSP90) is a key component of the molecular chaperone complex essential for activating many signalling proteins involved in the development and progression of pathogenic cellular transformation. AHsp90gene (BQHsp90) was cloned and characterized fromBabesiasp. BQ1 (Lintan), an ovineBabesiaisolate belonging toBabesia motasi-like group, by screening a cDNA expression library and performing rapid amplification of cDNA ends. The full-length cDNA ofBQHsp90is 2399 bp with an open reading frame of 2154 bp encoding a predicted 83 kDa polypeptide with 717 amino acid residues. It shows significant homology and similar structural characteristics toHsp90of other apicomplex organisms. Phylogenetic analysis, based on the HSP90 amino acid sequences, showed that theBabesiagenus is clearly separated from other apicomplexa genera. Five Chinese ovineBabesiaisolates were divided into 2 phylogenetic clusters, namelyBabesiasp. Xinjiang (previously designated a new species) cluster andB. motasi-like cluster which could be further divided into 2 subclusters (Babesiasp. BQ1 (Lintan)/Babesiasp. Tianzhu andBabesiasp. BQ1 (Ningxian)/Babesiasp. Hebei). Finally, the antigenicity of rBQHSP90 protein from prokaryotic expression was also evaluated using western blot and enzyme-linked immunosorbent assay (ELISA).
Immunophilin–protein interactions inPlasmodium falciparum
Authors: LENEGHAN DARREN , BELL ANGUS 
Published: July 2015

SUMMARYImmunophilins comprise two protein families, cyclophilins (CYPs) and FK506-binding proteins (FKBPs), and are the major receptors for the immunosuppressive drugs cyclosporin A (CsA) and FK506 (tacrolimus), respectively. Most eukaryotic species have at least one immunophilin and some of them have been associated with pathogenesis of infectious or parasitic diseases or the action of antiparasitic drugs. The human malarial parasitePlasmodium falciparumhas 13 immunophilin or immunophilin-like genes but the functions of their products are unknown. We set out to identify the parasite proteins that interact with the major CYPs, PfCYP19A and PfCYP19B, and the FKBP, PfFKBP35, using a combination of co-immunoprecipitation and yeast two-hybrid screening. We identified a cohort of putative interacting partners and further investigation of some of these revealed potentially novel roles in parasite biology. We demonstrated that (i)P. falciparumCYPs interacted with the heat shock protein 70, (ii) treatment of parasites with CYP ligands disrupted transport of the rhoptry-associated protein 1, and (iii) PfFKBP35 interacted with parasite histones in a way that might modulate gene expression. These findings begin to elucidate the functions of immunophilins in malaria. Furthermore, the known antimalarial effects of CsA, FK506 and non-immunosuppressive derivatives of these immunophilin ligands could be mediated through these partner proteins.
Acute fluoxetine modulates emotional processing in young adult volunteers
Authors: Capitão L. P. , Murphy S. E. , Browning M. , Cowen P. J. , Harmer C. J. 
Published: July 2015

BackgroundFluoxetine is generally regarded as the first-line pharmacological treatment for young people, as it is believed to show a more favourable benefit:risk ratio than other antidepressants. However, the mechanisms through which fluoxetine influences symptoms in youth have been little investigated. This study examined whether acute administration of fluoxetine in a sample of young healthy adults altered the processing of affective information, including positive, sad and anger cues.MethodA total of 35 male and female volunteers aged between 18 and 21 years old were randomized to receive a single 20 mg dose of fluoxetine or placebo. At 6 h after administration, participants completed a facial expression recognition task, an emotion-potentiated startle task, an attentional dot-probe task and the Rapid Serial Visual Presentation. Subjective ratings of mood, anxiety and side effects were also taken pre- and post-fluoxetine/placebo administration.ResultsRelative to placebo-treated participants, participants receiving fluoxetine were less accurate at identifying anger and sadness and did not show the emotion-potentiated startle effect. There were no overall significant effects of fluoxetine on subjective ratings of mood.ConclusionsFluoxetine can modulate emotional processing after a single dose in young adults. This pattern of effects suggests a potential cognitive mechanism for the greater benefit:risk ratio of fluoxetine in adolescent patients.
A metastructural model of mental disorders and pathological personality traits
Authors: Wright A. G. C. , Simms L. J. 
Published: July 2015

BackgroundPsychiatric co-morbidity is extensive in both psychiatric settings and the general population. Such co-morbidity challenges whether DSM-based mental disorders serve to effectively carve nature at its joints. In response, a substantial literature has emerged showing that a small number of broad dimensions – internalizing, externalizing and psychoticism – can account for much of the observed covariation among common mental disorders. However, the location of personality disorders within this emerging metastructure has only recently been studied, and no studies have yet examined where pathological personality traits fit within such a broad metastructural framework.MethodWe conducted joint structural analyses of common mental disorders, personality disorders and pathological personality traits in a sample of 628 current or recent psychiatric out-patients.ResultsBridging across the psychopathology and personality trait literatures, the results provide evidence for a robust five-factor metastructure of psychopathology, including broad domains of symptoms and features related to internalizing, disinhibition, psychoticism, antagonism and detachment.ConclusionsThese results reveal evidence for a psychopathology metastructure that (a) parsimoniously accounts for much of the observed covariation among common mental disorders, personality disorders and related personality traits, and (b) provides an empirical basis for the organization and classification of mental disorder.
Minimal clinically important difference on the Beck Depression Inventory - II according to the patient's perspective
Authors: Button K. S. , Kounali D. , Thomas L. , Wiles N. J. , Peters T. J. , Welton N. J. , Ades A. E. , Lewis G. 
Published: July 2015

BackgroundThe Beck Depression Inventory, 2nd edition (BDI-II) is widely used in research on depression. However, the minimal clinically important difference (MCID) is unknown. MCID can be estimated in several ways. Here we take a patient-centred approach, anchoring the change on the BDI-II to the patient's global report of improvement.MethodWe used data collected (n= 1039) from three randomized controlled trials for the management of depression. Improvement on a ‘global rating of change’ question was compared with changes in BDI-II scores using general linear modelling to explore baseline dependency, assessing whether MCID is best measured in absolute terms (i.e. difference) or as percent reduction in scores from baseline (i.e. ratio), and receiver operator characteristics (ROC) to estimate MCID according to the optimal threshold above which individuals report feeling ‘better’.ResultsImprovement in BDI-II scores associated with reporting feeling ‘better’ depended on initial depression severity, and statistical modelling indicated that MCID is best measured on a ratio scale as a percentage reduction of score. We estimated a MCID of a 17.5% reduction in scores from baseline from ROC analyses. The corresponding estimate for individuals with longer duration depression who had not responded to antidepressants was higher at 32%.ConclusionsMCID on the BDI-II is dependent on baseline severity, is best measured on a ratio scale, and the MCID for treatment-resistant depression is larger than that for more typical depression. This has important implications for clinical trials and practice.
Studies of ablated plasma and shocks produced in a planar target by a sub-nanosecond laser pulse of intensity relevant to shock ignition
Authors: Badziak J. , Antonelli L. , Baffigi F. , Batani D. , Chodukowski T. , Cristoforetti G. , Dudzak R. , Gizzi L.A. , Folpini G. , Hall F. , Kalinowska Z. , Koester P. , Krousky E. , Kucharik M. , Labate L. , Liska R. , Malka G. , Maheut Y. , Parys P. , Pfeifer M. , Pisarczyk T. , Renner O. , Rosiński M. , Ryć L. , Skala J. , Smid M. , Spindloe C. , Ullschmied J. , Zaraś-Szydłowska A. 
Published: July 2015

AbstractThe effect of laser intensity on characteristics of the plasma ablated from a low-Z(CH) planar target irradiated by a 250 ps, 0.438 µm laser pulse with the intensity of up to 1016W/cm2as well as on parameters of the laser-driven shock generated in the target for various scale-lengths of preformed plasma was investigated at the kilojoule Prague Asterix Laser System (PALS) laser facility. Characteristics of the plasma were measured with the use of 3-frame interferometry, ion diagnostics, an X-ray spectrometer, andKαimaging. Parameters of the shock generated in a Cl doped CH target by the intense 3ω laser pulse were inferred by numerical hydrodynamic simulations from the measurements of craters produced by the shock in the massive Cu target behind the CH layer. It was found that the pressure of the shock generated in the plastic layer is relatively weakly influenced by the preplasma (the pressure drop due to the preplasma presence is ~10–20%) and at the pulse intensity of ~1016W/cm2the maximum pressure reaches ~80–90 Mbar. However, an increase in pressure of the shock with the laser intensity is slower than predicted by theory for a planar shock and the maximum pressure achieved in the experiment is by a factor of ~2 lower than predicted by the theory. Both at the preplasma absence and presence, the laser-to-hot electrons energy conversion efficiency is small, ~1% or below, and the influence of hot electrons on the generated shock is expected to be weak.
Cancer patients' emotional distress, coping styles and perception of doctor-patient interaction in European cancer settings
Authors: Meggiolaro Elena , Berardi Maria Alejandra , Andritsch Elisabeth , Nanni Maria Giulia , Sirgo Agustina , Samorì Elena , Farkas Clemens , Ruffilli Federica , Caruso Rosangela , Bellé Marta , Juan Linares Eva , de Padova Silvia , Grassi Luigi 
Published: July 2015

AbstractObjective:As a part of a European study, we cross-culturally examined the rate of emotional distress and maladaptive coping and their association with cancer patients' satisfaction with their interactions with the physician responsible for their care.Methods:Cancer patients (n = 302) from one Middle European (Austria) and two Southern European (Italy, Spain) countries completed the NCCN Distress Thermometer (DT), the Mini-Mental Adjustment to Cancer (Mini-MAC) Anxious Preoccupation (AP) and Hopelessness (H) sub-scales, and the Physician Patient Satisfaction with Doctors Questionnaire (PSQ).Results:The prevalence of emotional distress (DT caseness) was 60% (26.1% mild, 18.8% moderate, and 14.9% severe distress). Maladaptive coping (Mini-MAC cases) was found in 22.8% (hopeless cases), and 22.5% (anxious preoccupation cases). PSQ-MD was significantly correlated with Mini-MAC/H and Mini-Mac/AP, while PSQ-PS was negatively correlated with Mini-MAC/H. DT cases and those with higher levels of hopelessness reported higher scores on PSQ-MD and lower on PSQ-PS than non-cases. Some differences were found between countries both as far as patients' coping and perception of the interaction with doctors. In hierarchical multiple regression analysis, after adjusting for socio-demographic and medical variables, Mini-MAC/H significantly predicted the scores on PSQ-MD (positive direction) and PSQ-PS (negative direction).Significance of results:The study confirms that about one out of three cancer patients have moderate to high level of emotional distress and about one out of four, clinically significant maladaptive coping. Also, patients showing hopelessness and distress tended to perceive their doctors as both disengaged and less supportive. These results highlights the need for physicians to monitor their patient's level of distress and coping mechanisms and to adjust their own relational and communication style according to patients' psychological condition. Also, cross-cultural issues should be taken into account when exploring psychosocial variables and cancer patients' perception of and satisfaction with the interaction with their doctors.
First records from the Ligurian Sea of the cold water species Okenia aspersa and Doto koenneckeri (Gastropoda: Nudibranchia)
Authors: Betti Federico , Cattaneo-Vietti Riccardo , Bava Simone 
Published: July 2015

Okenia aspersais a north-eastern Atlantic species, only previously recorded asOkenia quadricornisfrom the Malta Archipelago in the Mediterranean Sea, and in juvenile forms, from Sicily and the Gulf of Naples. A second adult specimen is recorded in the present paper, which was found along the Noli Cape coast, in the western Ligurian Sea (Italy). It was found on pebbles at a depth of 10 m. In the same area, at a depth of 5.5 m, two specimens ofDoto koenneckeriand three of their egg masses were found. This species, also described from Norway and Ireland, was only previously known to occur in the Mediterranean Sea off Spain and France. It is likely that the cold winter temperatures of the Ligurian Sea allowed this species to live and reproduce.
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing
Authors: Wang Z , Dove P , Wang X , Shamas-Din A , Li Z , Nachman A , Oh Y J , Hurren R , Ruschak A , Climie S , Press B , Griffin C , Undzys E , Aman A , Al-awar R , Kay L E , O'Neill D , Trudel S , Slassi M , Schimmer A D 
Published: July 2015

AbstractApproved proteasome inhibitors have advanced the treatment of multiple myeloma but are associated with serious toxicities, poor pharmacokinetics, and most with the inconvenience of intravenous administration. We therefore sought to identify novel orally bioavailable proteasome inhibitors with a continuous daily dosing schedule and improved therapeutic window using a unique drug discovery platform. We employed a fluorine-based medicinal chemistry technology to synthesize 14 novel analogs of epoxyketone-based proteasome inhibitors and screened them for their stability, ability to inhibit the chymotrypsin-like proteasome, and antimyeloma activity in vitro. The tolerability, pharmacokinetics, pharmacodynamic activity, and antimyeloma efficacy of our lead candidate were examined in NOD/SCID mice. We identified a tripeptide epoxyketone, FV-162, as a metabolically stable, potent proteasome inhibitor cytotoxic to human myeloma cell lines and primary myeloma cells. FV-162 had limited toxicity and was well tolerated on a continuous daily dosing schedule. Compared with the benchmark oral irreversible proteasome inhibitor, ONX-0192, FV-162 had a lower peak plasma concentration and longer half-life, resulting in a larger area under the curve (AUC). Oral FV-162 treatment induced rapid, irreversible inhibition of chymotrypsin-like proteasome activity in murine red blood cells and inhibited tumor growth in a myeloma xenograft model. Our data suggest that oral FV-162 with continuous daily dosing schedule displays a favorable safety, efficacy, and pharmacokinetic profile in vivo, identifying it as a promising lead for clinical evaluation in myeloma therapy.
Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA
Authors: Scarola Michele , Comisso Elisa , Pascolo Rhena , Chiaradia Riccardo , Maria Marion Rosa , Schneider Claudio , Blasco Maria A. , Schoeftner Stefan , Benetti Roberta 
Published: July 2015

AbstractPseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouseOct4pseudogenes and demonstrate that the X-linkedOct4pseudogeneOct4P4critically impacts mouse embryonic stem cells (mESCs) self-renewal. SenseOct4P4transcription produces a spliced, nuclear-restricted lncRNA that is efficiently upregulated during mESC differentiation.Oct4P4lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1α to the promoter of the ancestralOct4gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal. TargetingOct4P4expression in primary mouse embryonic fibroblasts causes the re-acquisition of self-renewing features of mESC. We demonstrate thatOct4P4lncRNA plays an important role in inducing and maintaining silencing of the ancestralOct4gene in differentiating mESCs. Our data introduces a sense pseudogene–lncRNA-based mechanism of epigenetic gene regulation that controls the cross-talk between pseudogenes and their ancestral genes.
Synthesis of quasi-free-standing bilayer graphene nanoribbons on SiC surfaces
Authors: Oliveira, Myriano H. , Lopes Joao Marcelo J. , Schumann Timo , Galves Lauren A. , Ramsteiner Manfred , Berlin Katja , Trampert Achim , Riechert Henning 
Published: July 2015

AbstractScaling graphene down to nanoribbons is a promising route for the implementation of this material into devices. Quantum confinement of charge carriers in such nanostructures, combined with the electric field-induced break of symmetry in AB-stacked bilayer graphene, leads to a band gap wider than that obtained solely by this symmetry breaking. Consequently, the possibility of fabricating AB-stacked bilayer graphene nanoribbons with high precision is very attractive for the purposes of applied and basic science. Here we show a method, which includes a straightforward air annealing, for the preparation of quasi-free-standing AB-bilayer nanoribbons with different widths on SiC(0001). Furthermore, the experiments reveal that the degree of disorder at the edges increases with the width, indicating that the narrower nanoribbons are more ordered in their edge termination. In general, the reported approach is a viable route towards the large-scale fabrication of bilayer graphene nanostructures with tailored dimensions and properties for specific applications.