bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panic disorder and sleep disorders
Authors: Korabelnikova E. A. , Yakovleva E. V. 
Published: August 2024

Introduction. Panic disorder (PD) are common problems in both primary and psychiatric specialty care. PD includes panic attacks (PA). PA are characterized by a sudden wave of fear or discomfort or a sense of losing control even when there is no clear danger or trigger. PD is frequently comorbid with sleep disorders, especially insomnia, сlosely interrelated etiopatogenically and worsen each other’s flow.Aim. To evaluate the severity of the impact of sleep disturbances on the condition of patients with panic disorder and their dynamics during therapy.Materials and methods. The study included 46 patients including 26 with a PD and sleep disturbances, assigned to the main group, and 20 healthy patients. The study design included clinical, anamnestic and psychometric methods (Sheehan scale, State-T rait Anxiety Inventory (STAI)) and sleep quality scales (Pittsburgh Sleep Quality Index (PSQI), Spiegel questionnaire). Participants in the main group received psychoeducation and drug correction of PD (without the use of sedatives). A few months later, patients in the main group were re-tested.Results. The results of the study indicate an obvious dependence of manifestation of clinical manifestations of panic disorder (agoraphobia attachment) and emotional disorders on the degree of severity of accompanying insomnia. With PR treatment not focused on correcting sleep disorders, patients experienced not only statistically significant reductions in Shihan levels of anxiety and trait anxiety in the STAI, but also statistically significant improvements in sleep quality.Conclusion. Dependence of manifestation of clinical manifestations of panic disorder and emotional disorders on degree of manifestation of accompanying insomnia is shown. A panic disorder correction aimed at reducing anxiety led to a significant improvement in sleep subjectivity and psychometric testing.
The prognostic value of hematological indices in systemic inflammatory diseases of connective tissue
Authors: Manzyuk A. V. , Morozova T. E. , Gertsog A. A. , Litvinova M. A. 
Published: August 2024

Introduction. The lack of available and effective laboratory markers makes predicting exacerbations and progression in systemic inflammatory diseases of connective tissue an intractable task for rheumatologists and primary care specialists who monitor patients. Hematological indices calculated from a complete blood count have demonstrated effectiveness in predicting the course of several diseases.Aim. To determine the prognostic value of hematological indices of complete blood count (RDW, MPV, PLR, NLR, LMR, PMR,PNR, SII) in predicting exacerbations and progression of systemic inflammatory diseases of connective tissueMaterials and methods. For a retrospective observational case-control study, patients with systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (microscopic polyangiitis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis) were selected. Patients with an exacerbation or progression of the disease that occurred within 3–12 months were assigned to the main group, patients with stable disease were assigned to the control group.Results. 60 patients were selected, of which 25 had an exacerbation or progression over the next 3–12 months, 35 had a stable course of the disease. The initial clinical and demographic characteristics of patients had no significant differences, including between the subgroups with ANCA-associated vasculitis (n = 35) and systemic lupus erythematosus (n = 25). Patients in the main group had a higher initial erythrocyte distribution width (p < 0.001). Statistically significant differences were observed between the groups in the baseline level of platelet-lymphocytic, neutrophil-lymphocytic, platelet-neutrophil ratios and the index of systemic inflammation, but in the subgroups of SLE and ANCA-associated vasculitis, the differences were divergent.Conclusion. The red blood cell distribution width demonstrated a higher prognostic value in relation to exacerbations and progression of ANCA-associated vasculitis and SLE compared with ESR and C-reactive protein and appears to be the most universal among the studied markers of prognosis of systemic inflammatory diseases of connective tissue.
Outpatient management of patients with vascular cognitive impairment
Authors: Pizova N. V. , Pizov A. V. 
Published: August 2024

Age-related cognitive impairment is one of the top public health challenges nowadays. Vascular cognitive impairment (VCI) includes a broad spectrum of cognitive disorders, from clinically mild cognitive impairment, which is revealed only due to cognitive testing, to moderate and severe ones reaching the level of dementia. Vascular cognitive impairment covers the full spectrum of neurological disorders caused by cerebrovascular diseases. The neuropathology of cognitive impairment in later life is often a mixture of vascular pathology, Alzheimer disease, and other neurodegenerative diseases, which overlap and heighten the risk of cognitive impairment. Cognitive impairment is defined by the presence of a progressive reduction in cognitive abilities, worsening both of memory and attention, which leads to increased dependence and social isolation. Cerebrovascular risk factors are common among older adults and are major contributors to the development of vascular cognitive impairment. The most common vascular risk factors include hypertension, high cholesterol levels, diabetes and smoking, which have high prevalence rates in the population. The main causes of vascular cognitive impairment are considered to be acute cerebrovascular accidents, silent (asymptomatic) infarctions and cerebral microbleeds combined with or without white matter (WM) structural integrity and density changes. Cerebral small vessel disease is one of the most topical due to its effect in terms of socioeconomic burden. The use of neuroimaging, in particular magnetic resonance imaging, greatly improves the ability to identify the contribution of vascular diseases to the development of vascular cognitive impairment. Currently, no specific treatments for vascular cognitive impairment exist, but standard stroke prevention measures are recommended. Multimodal interventions including vascular risk factors and lifestyle modifications is currently the most promising treatment and prevention strategy. Cholinergic precursors were among the first compounds used to treat cognitive impairment.
The possibilities of using effective anti-anxiety therapy in the practice of a neurologist
Authors: Aronov P. V. , Belskaya G. N. , Cherepakhin D. I. 
Published: August 2024

According to the diagnostic criteria for generalized anxiety disorder in ICD-10, the obligatory symptoms of anxiety are somatic (vegetative) manifestations, represented by a whole spectrum of disorders vital to the patient: cardiovascular, respiratory, neurological, gastrointestinal, urogenital, thermoregulatory, motor. Classic benzodiazepine drugs, such as phenazepam, alprazolam, and clonazepam, are quite effective in anxiolytic therapy. However, they have pronounced side effects, such as decreased reaction speed, drowsiness, weight gain, decreased libido, nervousness, headache, and others. With long-term use, side effects develop in more than 90% of patients. Side effects can significantly impair the patient’s quality of life and carry many hidden disorders of mental and somatic health. Etifoxine has a unique mechanism of action that includes allosteric effects on GABA(A) receptors and modulation of neurosteroid metabolism. It is effective in the treatment of anxiety disorders, reducing somatic and mental manifestations of anxiety. Etifoxine also has anti-inflammatory and neurotrophic effects. It does not cause dependence and withdrawal syndrome, does not affect psychomotor functions, and has high safety. Studies show that etifoxine can be recommended for widespread use in general medical practice as an effective and safe drug for daytime use to alleviate anxiety in various comorbid pathologies, especially in general neurological practice. It is a valuable tool for improving the quality of life of patients with anxiety disorders, especially when there are accompanying somatic manifestations of anxiety and comorbid neurological pathology.
The Relationship of Transposable Elements with Non-Coding RNAs in the Emergence of Human Proteins and Peptides
Authors: Mustafin Rustam Nailevich 
Published: August 2024

:
Transposable elements are the oldest structural and functional units that were formed
during the emergence of life on Earth. The most ancient properties of transposable elements are
the multifunctionality of their transcription and translation products and the formation of their
many variants through processing, due to which transposable elements are key evolutionary
sources of long non-coding RNAs, circular RNAs, microRNAs, proteins and peptides formation.
Moreover, the same type of transposon can simultaneously serve as the source of the origin of all
these molecules, providing the adaptive properties of living organisms, especially complex eukaryotes,
including humans. The ancient ability of transposable elements for mutual integration due to
their protein products interacting with DNA and RNA molecules, as well as for mutual regulation
due to the functionality of their RNA, is the basis for the origin of many proteins and non-coding
RNAs characterized by the same properties. This can explain the emergence of transcription factors
from transposable elements, that is, proteins capable of interacting with the structures of DNA
molecules due to the presence of specific amino acid sequences derived from transposable elements.
This article presents facts about the origin during the evolution of many protein and non--
coding RNA genes from transposable elements. Specific proteins and peptides translated from
long non-coding RNAs, pri-microRNAs and circular RNAs are described, which reflect the origin
of non-coding RNAs from transposable elements in evolution. These proteins and peptides are
promising tools for the treatment of viral infections and drug-resistant tumors, since, together with
non-coding RNAs, they are involved in antiviral and antitumor responses.
Recent Advancement and Novel Treatment Strategies for Breast Fibroadenoma: Clinical Approach and Prospects
Authors: Sahu Nandita , Jain Parag , Nagori Kushagra , Ajazuddin  
Published: August 2024

Abstract:
Breast fibroadenoma, a common benign tumor, presents unique challenges in diagnosis
and management. This review article aimed to incorporate various aspects of fibroadenoma, including
diagnostic methods, treatment modalities, clinical case descriptions, and recent research
advancements. A comprehensive review of the literature and analysis of clinical cases were conducted
to elucidate the characteristics and management strategies of this condition. The morphological
size and nature of fibroadenoma were discussed, and clinical epidemiology and pathophysiology
were presented. The outcome of this study was to describe the importance of accurate diagnosis
through imaging techniques and histopathological examination. Furthermore, we explored
evolving treatment options, such as minimally invasive procedures and surveillance protocols for
conservative management. This article contributes to a deeper understanding of breast fibroadenoma
and informs clinical practice. Nonetheless, further research is warranted to refine diagnostic
and therapeutic approaches for optimal patient outcomes.
Cold Chain Logistics Vehicle Path Optimization Based on Improved Artificial Bee Colony Algorithm
Authors: Pughazendi N. , Lalitha K. , Chitra D. , Esakkiappan C. , Pandian M. Thurai 
Published: August 2024

Aims and Background:
Cold Chain Logistics is defined as the secure storage, transportation,
and handling of temperature-sensitive items from the origin of production to the consumer
end. Transport and warehouses with refrigeration systems have been used in this process. Cold
chain logistics plays a key role in safely transporting food items to consumers.

Objectives and Methodology:
In this research article, we have proposed an improved Artificial Bee
Colony (ABC) algorithm for the path optimization method of cold chain logistics vehicles. It is difficult
to transfer resources across borders, there is no information sharing, and there are geographical
restrictions with traditional regional distribution systems. Reaching the consumer end in less
time, distance, and expense is made possible in large part by the cold chain logistics vehicle. Data
about the flow of traffic on the roads is taken into account when choosing routes.

objective:
: In this research article, we have proposed an improved artificial bee colony algorithm for path optimization method of cold chain logistics vehicles. It is difficult to transfer resources across borders, there is no information sharing, and there are geographical restrictions with traditional regional distribution systems. Reaching the consumer end in less time, distance, and expense is made possible in large part by the cold chain logistics vehicle. Data about the flow of traffic on the roads is taken into account when choosing routes. Path optimization methods are employed in this. One of the artificial swarm intelligence algorithms that is based on the functionality of bee colonies is the Artificial Bee Colony(ABC) Algorithm. The cold chain logistics(CCL) path is optimized with the aid of Internet technology and Global Positioning System technology. For the delivery of temperature-sensitive items, the most efficient short route is identified.

Result:
Path optimization methods are employed in this study. One of the artificial swarm intelligence
algorithms that is based on the functionality of bee colonies is the ABC algorithm. The Cold
Chain Logistics (CCL) path is optimized with the aid of Internet technology and Global Positioning
System technology. For the delivery of temperature-sensitive items, the most efficient short route is
identified.

Conclusion:
The main aim of this research is to reduce the time, distance, and cost involved in
transportation. The algorithm has provided an accuracy of 98.74% in attaining effective transportation
of cold logistics and optimal path selection.
Censorship in Early Childhood: A Critical Content Analysis of Banned and Challenged Latine Picture Books
Authors: Rodriguez Sanjuana , Osorio Sandra 
Published: August 2024

Book bans have historically been used to limit the types of books that students have access to, especially for communities of Color and historically marginalized groups. Using Critical Race Content Analysis, we analyzed how Latine individuals and experiences are portrayed in banned/challenged picture books to understand the experiences portrayed in the texts. We identified ten Latine picture book titles that were banned or challenged and also award winners. We found that Latine picture books that were challenged or banned included experiential knowledge, the centrality of race and racism, challenged the dominant ideology of Latine communities, included interdisciplinary perspectives, and exhibited a commitment to social justice. All children, especially Latine children, should engage and discuss children's books that include the Latine experience and their own stories.
Enhancing Medical Interview Skills Through AI-Simulated Patient Interactions: Nonrandomized Controlled Trial
Authors: Yamamoto Akira , Koda Masahide , Ogawa Hiroko , Miyoshi Tomoko , Maeda Yoshinobu , Otsuka Fumio , Ino Hideo 
Published: August 2024

Background
Medical interviewing is a critical skill in clinical practice, yet opportunities for practical training are limited in Japanese medical schools, necessitating urgent measures. Given advancements in artificial intelligence (AI) technology, its application in the medical field is expanding. However, reports on its application in medical interviews in medical education are scarce.

Objective
This study aimed to investigate whether medical students’ interview skills could be improved by engaging with AI-simulated patients using large language models, including the provision of feedback.

Methods
This nonrandomized controlled trial was conducted with fourth-year medical students in Japan. A simulation program using large language models was provided to 35 students in the intervention group in 2023, while 110 students from 2022 who did not participate in the intervention were selected as the control group. The primary outcome was the score on the Pre-Clinical Clerkship Objective Structured Clinical Examination (pre-CC OSCE), a national standardized clinical skills examination, in medical interviewing. Secondary outcomes included surveys such as the Simulation-Based Training Quality Assurance Tool (SBT-QA10), administered at the start and end of the study.

Results
The AI intervention group showed significantly higher scores on medical interviews than the control group (AI group vs control group: mean 28.1, SD 1.6 vs 27.1, SD 2.2; P=.01). There was a trend of inverse correlation between the SBT-QA10 and pre-CC OSCE scores (regression coefficient –2.0 to –2.1). No significant safety concerns were observed.

Conclusions
Education through medical interviews using AI-simulated patients has demonstrated safety and a certain level of educational effectiveness. However, at present, the educational effects of this platform on nonverbal communication skills are limited, suggesting that it should be used as a supplementary tool to traditional simulation education.
Assessment of Wearable Device Adherence for Monitoring Physical Activity in Older Adults: Pilot Cohort Study
Authors: Ding Huitong , Ho Kristi , Searls Edward , Low Spencer , Li Zexu , Rahman Salman , Madan Sanskruti , Igwe Akwaugo , Popp Zachary , Burk Alexa , Wu Huanmei , Ding Ying , Hwang Phillip H , Anda-Duran Ileana De , Kolachalama Vijaya B , Gifford Katherine A , Shih Ludy C , Au Rhoda , Lin Honghuang 
Published: August 2024

Abstract

Background
Physical activity has emerged as a modifiable behavioral factor to improve cognitive function. However, research on adherence to remote monitoring of physical activity in older adults is limited.

Objective
This study aimed to assess adherence to remote monitoring of physical activity in older adults within a pilot cohort from objective user data, providing insights for the scalability of such monitoring approaches in larger, more comprehensive future studies.

Methods
This study included 22 participants from the Boston University Alzheimer’s Disease Research Center Clinical Core. These participants opted into wearing the Verisense watch as part of their everyday routine during 14-day intervals every 3 months. Eighteen continuous physical activity measures were assessed. Adherence was quantified daily and cumulatively across the follow-up period. The coefficient of variation was used as a key metric to assess data consistency across participants over multiple days. Day-to-day variability was estimated by calculating intraclass correlation coefficients using a 2-way random-effects model for the baseline, second, and third days.

Results
Adherence to the study on a daily basis outperformed cumulative adherence levels. The median proportion of adherence days (wearing time surpassed 90% of the day) stood at 92.1%, with an IQR spanning from 86.9% to 98.4%. However, at the cumulative level, 32% (7/22) of participants in this study exhibited lower adherence, with the device worn on fewer than 4 days within the requested initial 14-day period. Five physical activity measures have high variability for some participants. Consistent activity data for 4 physical activity measures might be attainable with just a 3-day period of device use.

Conclusions
This study revealed that while older adults generally showed high daily adherence to the wearable device, consistent usage across consecutive days proved difficult. These findings underline the effectiveness of wearables in monitoring physical activity in older populations and emphasize the ongoing necessity to simplify usage protocols and enhance user engagement to guarantee the collection of precise and comprehensive data.
Analysis of the Construction of Gender Roles of Male Characters in The Wedding Banquet
Authors: Liu Chang 
Published: August 2024

Ang Lee is a successful director who has won the Oscar for the best director of the film Life of Pi, the Golden Bear for the film Brokeback Mountain and the Oscar for Crouching Tiger, Hidden Dragon. There is no doubt that Ang Lee is a milestone-like director throughout the history of Chinese film. Having been born in China and graduated from the apartment of director in New York University, Ang Lee has been deeply influenced by both Chinese and American culture. Therefore, his works creatively integrate East and West, Chinese-speaking world and Hollywood tradition, combine Chinese traditional aesthetic style with Hollywood classic expression, and show strong cross-cultural ability. Gender has always been one of the most important dimensions of Ang Lee’s films. His films often put marginal gender identities-women and homosexuals-at the core of narrative. In the film, The Wedding Banquet, Ang Lee has told a story in which the homosexual son has finally made a compromise. However, due to Ang Lee’s living environment and educational background, he wants to solve this problem of gender duality with a mild and non-confrontational way.The Theory of Gender Performativity has first been raised by Judith Bulter in the 1980s. It is one of the most important theories of Feminism. This theory holds the view that gender is regulated by the society. Gender itself isn’t expressive, but it requires people to be performative, thus forming the stereotype of men and women.This paper will be divided into four parts. It will get started with the introduction part-the introduction of Ang Lee and his film The Wedding Banquet and literature review. The second part is theoretical framework. In this part, the author will introduce the Theory of Performativity raised by Judith Bulter and the possibility to use this theory to analyze the construction of gender roles of male characters in The Wedding Banquet. The third part discusses the construction of gender roles of three male characters Gao, Gao Weitong’s father and Simon in The Wedding Banquet to show Ang Lee’s rebellion and compromise against the patriarchal society. Complex and diverse male images in this film appear in this film, which are full of personal characteristics and show rebellion against tradition.What’s more, the construction of female characters will also be mentioned to illustrate that women have undergone the oppression of the patriarchal society. The last part is the conclusion part. Through the analysis of the construction of gender roles of male characters, this paper will state the truth that although the director Ang Lee has tried his best to show his inclusiveness of homosexuals, the special gender group, he has still compromised to the patriarchal tradition due to his educational background and cultural background. Ang Lee has attached great importance to family issue and talked about the gender trouble which bothered both men and women, thus eliminating the difference between men and women and criticizing heterosexual hegemony in the patriarchal society.