bluuebunny/crossref_metadata_2025_split huggingface dataset:
The combination of milatuzumab, a humanized anti‐CD74 antibody, and veltuzumab, a humanized anti‐CD20 antibody, demonstrates activity in patients with relapsed and refractory B‐cell non‐Hodgkin lymphoma
Authors: Christian Beth A. , Poi Ming , Jones Jeffrey A. , Porcu Pierluigi , Maddocks Kami , Flynn Joseph M. , Benson Don M. , Phelps Mitch A. , Wei Lai , Byrd John C. , Wegener William A. , Goldenberg David M. , Baiocchi Robert A. , Blum Kristie A. 
Published: April 2015

SummaryAs a result of the anti‐tumour activity observed in vitro and in vivo with combined anti‐CD20 and anti‐CD74 antibodies, we initiated a phase I/II trial of veltuzumab and milatuzumab in patients with relapsed or refractory B‐cell non‐Hodgkin lymphoma (NHL). Patients received an induction of veltuzumab 200 mg/m2 weekly combined with escalating doses of milatuzumab at 8, 16 and 20 mg/kg weekly for 4 weeks. Patients without disease progression could receive an extended induction with treatment on weeks 12, 20, 28 and 36. A total of 35 patients enrolled on the study. Median age was 63 years, median number of prior therapies was 3, and 63% of patients were rituximab refractory. No dose‐limiting toxicities were observed in the phase I study. Related grade 3–4 toxicities included lymphopenia, leucopenia, neutropenia, anaemia, infusion reactions, hyperglycaemia, fatigue and atrial tachycardia. Median weeks of therapy was 12 and 29% of patients completed all 36 weeks of therapy. The overall response rate was 24%, median duration of response was 12 months, and responses were observed at all dose levels and in 50% of patients refractory to rituximab. Combination therapy with veltuzumab and milatuzumab demonstrated activity in a population of heavily pre‐treated patients with relapsed or refractory indolent NHL.
Lack of effect of sacral nerve stimulation for incontinence in patients with systemic sclerosis
Authors: Butt S. K. , Alam A. , Cohen R. , Krogh K. , Buntzen S. , Emmanuel A. 
Published: April 2015

AbstractAimSystemic sclerosis (SSc) is a multisystem disorder of unknown aetiology leading to the deposition of excessive connective tissue in the skin, blood vessels and internal organs. Gastrointestinal involvement occurs in 90% of cases and the prevalence of faecal incontinence (FI) is 38%. This study comprises the largest case series assessing the efficacy of sacral nerve stimulation (SNS) treatment for incontinence in this patient group.MethodA retrospective analysis on prospectively collected data was performed on all SSc patients from our two centres who had undergone SNS for FI.ResultsTen female patients of mean age of 54 (37–72) years had temporary SNS performed. The mean duration of FI was 13 (2–25) years. All had passive FI. Each patient had preprocedure anorectal physiology and endoanal ultrasound examinations documenting internal sphincter atrophy/fragmentation or reduced anal resting pressure. Overall there was no statistically significant difference (P = 0.57) in the total Wexner incontinence scores before (mean 15.1 ± 2.6 SD) and during temporary SNS procedures (mean 13.1 ± 3.6 SD). Two patients with a significant improvement went on to have permanent SNS with only one achieving a favourable outcome at 1 year.ConclusionThis study showed that SNS failed to reduce episodes of leakage in nine out of 10 patients with systemic sclerosis affected with incontinence.
The effect of sirolimus‐based immunosuppression vs. conventional prophylaxis therapy on cytomegalovirus infection after liver transplantation
Authors: Sheng Liu , Jun Shi , Jianfeng Li , Lianghui Gao 
Published: April 2015

AbstractObjectiveThe aim of this study was to assess the efficacy of sirolimus‐based immunosuppression vs. conventional prophylaxis therapy in preventing cytomegalovirus (CMV) infection or disease in liver transplantation recipients.MethodsOne hundred and twenty‐seven consecutive liver transplant recipients, with a minimum of one‐yr follow‐up from 2008 to 2013 in the first affiliated hospital of Nanchang University, were retrospectively divided into the sirolimus‐treated (n = 51) and ganciclovir‐treated (n = 76) groups. The CMV incidence, rejection events, and survival rate were compared.ResultsThe overall incidences of CMV events were decreased but did not reach statistical significance in the sirolimus arm compared with the ganciclovir arm (p > 0.05) at one yr after liver transplantation. There was no significant difference in the rejection incidence and survival rates between the two groups.ConclusionsSirolimus‐based immunosuppression had a lower incidence of CMV infection compared with conventional prophylaxis therapy and did not increase rejection risks and mortality after liver transplantation, indicating that with the use of an mammalian target‐of‐rapamycin (mTOR)‐inhibitor, CMV prophylaxis may be dispensable.
To Use or Not to Use—ERP Resistance is the Question: The Roles of Tacit Knowledge and Complexity
Authors: Freeze Ronald D. , Schmidt Pamela J. 
Published: April 2015

ABSTRACTEnterprise Resource Planning (ERP) systems in business environments demand multidisciplinary understanding and collaboration between functional departments. The traditional educational paradigm isolates the learning of each functional discipline as if business people operated in functional isolation. ERP system value can only be realized by collaborating across business functions. Integral to the success of ERP use is the tacit or unconscious understanding of the concepts underlying business processes and the dynamic interplay of collaborating business functions. Resistance to ERP systems often occur due to the high complexity of these business processes. This study describes an experiment in ERP based on an immersive experiential learning environment using the leading commercial ERP system to create a realistic and dynamic business situation. Multidisciplinary knowledge is measured by multiple methods of self‐reported and knowledge structure assessment. Survey measures of both declarative and tacit knowledge are used to assess student learning, and standard measures assess perceived resistance to ERP use. Results show perceived complexity to be a parsimonious predictor of resistance to ERP use. Findings further support the importance of assessing tacit knowledge (gained from conceptual experiential learning), and demonstrates avenues to create a highly effective multidisciplinary learning program.
Early Phases of Business Model Innovation: An Ideation Experience Workshop in the Classroom
Authors: Hoveskog M. , Halila F. , Danilovic M. 
Published: April 2015

ABSTRACTAs the mantra “innovate your business model or die” increases in popularity among practitioners and academics, so does the need for novel and feasible business models. In this article, we describe an ideation experience workshop, conducted in an undergraduate business course, in which students, guided by their lecturers and two industry representatives, developed business models in the early phases of a company's new blood alcohol level testing device. The students based their business models on the nine building blocks of a Business Model Canvas tool. The workshop confirmed that the three learning objectives were achieved as students acquired knowledge, created problem solutions, and presented results. The success of the workshop is attributable to the opportunity it gives students to work with an actual company, to experiment with business model innovation, and to learn from evaluators’ feedback.
Development of a conceptual model of health‐related quality of life among hepatitis C patients: A systematic review of qualitative studies
Authors: Mhatre Shivani K. , Sansgiry Sujit S. 
Published: April 2015

AbstractAimThe Food and Drug Administration guidelines emphasize that patient‐reported outcome (PRO) instruments used in clinical trials must be developed based on a conceptual model, yet existing PRO instruments currently used in clinical trials of hepatitis C virus (HCV) patients are not based on a predetermined model. The purpose of this study was to identify a comprehensive list of health‐related quality of life (HRQoL) themes that may be unique to HCV by reviewing qualitative research articles of HCV patients. The information collected from the review was used to develop a preliminary model of HRQoL in HCV patients.MethodsOvid Medline, Ovid Embase, Ovid PsycINFO and PubMed were searched for peer‐reviewed journals from 1989 to 2012. Set inclusion/exclusion criteria were utilized with a focus on HRQoL among HCV patients. Eligible articles that met quality assessment criteria were analyzed using meta‐synthesis to generate categories and themes to propose a conceptual model.ResultsTen articles that met the inclusion/exclusion criteria and the quality assessment criteria were reviewed. Eleven themes were identified: physical symptoms, physical activities, guilt, stigma, emotional distress, psychological behavior, social relationship, social activities, work function, sexual function and cognitive function. These were further grouped into six HRQoL domains: physical, psychological/emotional, social, work, sexual and cognitive functionality.ConclusionThe systematic review and the proposed model represent a useful starting point in the critical appraisal of the conceptual underpinnings of PRO instruments used in HCV patients.
Treatment of Periodontal Disease with an Octenidine‐based Antiseptic in HIV‐positive Patients
Authors: Gušić I , Medić D , Radovanović Kanjuh M , Ðurić M , Brkić S , Turkulov V , Predin T , Mirnić J 
Published: April 2015

AbstractObjectiveTo evaluate the effects of a periodontal therapy with subsequent application of an octenidine (OCT)‐based antiseptic in HIV‐positive patients receiving highly active antiretroviral therapy.MethodsHIV‐positive patients with a clinically diagnosed periodontal disease were randomly divided into two groups (n = 30/group). Both groups initially received a periodontal therapy. Patients in the OCT group additionally used an OCT‐based mouthwash. Subgingival plaque samples and periodontal indices were analysed prior to treatment onset as well as one and 3 months post‐treatment.ResultsPeriodontal therapy has resulted in a significant decrease in the values of all periodontal indices one and 3 months following the therapy completion (P = 0.000). The effects of the two applied therapeutic protocols differed significantly in terms of the variation in the PBI (F = 4.617; P = 0.017) and the PD (F = 3.203; P = 0.044) value. In the patients in the OCT group, a more pronounced decrease in the PBI and PD was noted at 1‐month follow‐up as well as a greater increase in the PD value 3 months upon treatment completion. In the OCT group, no more atypical microorganisms were detectable 1 month post‐treatment, while in the control group they were found in 34.5% of patients.ConclusionsThe periodontal therapy bears good results in HIV‐positive patients. Additional administration of OCT contributes to the significant decline in the PBI and DS values and eliminates atypical microorganisms within 1 month post‐treatment. However, more favourable results were not noted in the OCT group at the 3‐month assessment.
Rethinking the concept of consumer empowerment: recognizing consumers as citizens
Authors: McShane Lindsay , Sabadoz Cameron 
Published: April 2015

AbstractA clear understanding of consumer empowerment is central to enriching research regarding the business‐society interface and, more tangibly, the advancement of public policy. We aim to provide a clear and comprehensive understanding of the complex concept of consumer empowerment. To do so, we use historical analysis to critically examine and deconstruct the current, dominant conceptualization that equates consumer empowerment with choice. Subsequently, drawing on the paradigm of critical theory, we develop an alternate definition of the concept that more fully recognizes the citizenship role enacted by individuals in their daily lives. We conclude by discussing on how this renewed understanding can be implemented in both future research and public policy.
High‐intensity sweeteners in espresso coffee: ideal and equivalent sweetness and time–intensity analysis
Authors: Azevedo Bruna M. , Schmidt Flávio L. , Bolini Helena M. A. 
Published: April 2015

SummaryThe efficient substitution of sucrose by a sweetener in beverages requires the application of some sensory techniques. First, one must determine the concentrations of the sweeteners under study, equivalent in sweetness to the ideal sucrose concentration. In addition, it is fundamental to determine which is most similar to sucrose. The objectives of this study were to determine the ideal sweetness for espresso coffee and the equivalent concentrations in sweetness of different sweeteners, as well as characterise the time–intensity profile of each sweetener in relation to sweetness. The sweeteners evaluated were sucralose, aspartame, neotame, a cyclamate/saccharin mixture (2:1) and stevia. The sucrose concentration considered ideal by consumers was 12.5% (w/v), and the equivalent concentrations of the sweeteners were 0.0159% for sucralose, 0.0549% for aspartame, 0.0016% for neotame, 0.0359% for the cyclamate/saccharin mixture and 0.0998% for stevia. The time–intensity analysis indicated that possibly the sweeteners neotame, aspartame and sucralose would be the best substitutes for sucrose.
Study on microwave‐accelerated casein protein grafted with glucose and β‐cyclodextrin to improve the gel properties
Authors: Bi Weiwei , Zhao Weili , Li Xiaodong , Ge Wei , Muhammad Zafarullah , Wang Haixia , Du Lingling 
Published: April 2015

SummaryThe effect of glycosylation treatment coupled with microwave heating (MH) on gel properties and structure change of casein were investigated. Conjugation was confirmed by electrophoresis. Protein disulphide bonds were broken by microwave irradiation to create an increase first and a decrease later in free sulfhydryl contents with time, thereby inducing subunit disaggregation. Also, the exposure of hydrophobic core residues was increased in MH‐treated casein, which brings about protein disaggregation and unfolding. It showed that graft reactions by MH had much faster than those by water bath heating (WH). The content of disulphide bonds is 7.2% and 6.0% in the casein–glucose and casein–β‐cyclodextrin, respectively, treated by MH which was reduced significantly than that of treated by WH. Moreover, MH can increase the hardness of the gel. Consequently, MH could improve the efficiency of the reaction and gel properties.
Prostate‐specific antigen‐based prostate cancer screening: Past and future
Authors: Alberts Arnout R , Schoots Ivo G , Roobol Monique J 
Published: April 2015

AbstractProstate‐specific antigen‐based prostate cancer screening remains a controversial topic. Up to now, there is worldwide consensus on the statement that the harms of population‐based screening, mainly as a result of overdiagnosis (the detection of clinically insignificant tumors that would have never caused any symptoms), outweigh the benefits. However, worldwide opportunistic screening takes place on a wide scale. The European Randomized Study of Screening for Prostate Cancer showed a reduction in prostate cancer mortality through prostate‐specific antigen based‐screening. These population‐based data need to be individualized in order to avoid screening in those who cannot benefit and start screening in those who will. For now, lacking a more optimal screening approach, screening should only be started after the process of shared decision‐making. The focus of future research is the reduction of unnecessary testing and overdiagnosis by further research to better biomarkers and the value of the multiparametric magnetic resonance imaging, potentially combined in already existing prostate‐specific antigen‐based multivariate risk prediction models.
Information Systems Journal Special Issue on: Activity Theory in Information Systems Research
Authors: Karanasios Stan , Allen David , Finnegan Patrick 
Published: April 2015

AbstractActivity Theory, based on the work of Vygotsky and colleagues, has developed into a contemporary social theory for studying work and social activity. In the last 20 years it has become internationalised and accepted in the Organisation, Management, Human Computer Interaction, Social‐Psychology and Education fields; yet traditionally its use in IS has remained limited. In recent years there has been growing interest in its use in Information Systems (IS) research. This Special Issue aims to act as a compendium of outstanding research, focusing on the use, development and contribution of Activity Theory in IS research. It also aims to stimulate discourse and advance the use of Activity Theory in IS research.
Public transit planning and scheduling based on AVL data in China
Authors: Shen Yindong , Xu Jia , Zeng Zhongyi 
Published: April 2015

AbstractThe public transit operations planning process commonly includes the following activities: network route design, service planning (frequency setting and timetabling), and scheduling (vehicle scheduling, crew scheduling, and rostering). However, the network route design is generally the only one widely recognized, while service planning and scheduling are often ignored in China. This leads to the lack of elaborate timetables and schedules, hence, transit operation is often in disorder with high operating costs. To raise the service level and the utilization of resources, this paper presents an applied study for three cities in China, focusing on the enhancement of the recognition and execution of public transit planning and scheduling. A comprehensive framework of public transit planning is first proposed, which is composed of three traditional Chinese items (i.e. network route design, land use for depots, and deployment of vehicles) and the following newly added items: intelligent public transit system (IPTS) planning, service planning, and scheduling. This is pioneering work in China, in which an IPTS plan is conceived and a new vehicle scheduling approach based on AVL data is developed. Experiments during actual projects show that vehicle schedules with high on‐time probability and low cost were compiled, while the essential input parameters such as headways and trip times were set automatically. It is anticipated that the fruits of this research and the practical experience obtained would be of great benefit in improving service and management levels and resource use in public transport in China and some other developing countries.
The shifting boundaries of industrial relations: Insights from South Africa
Authors: WEBSTER Edward 
Published: April 2015

AbstractPost‐apartheid South Africa's turbulent industrial relations and experience of wider social protest movements mirror the challenges confronting industrial relations systems globally, suggesting how workers' representation could be reconfigured in the future. Traditional trade unions have so far failed to address the agenda of marginalization, inequality and poverty which might have enabled them to organize workers currently excluded from union membership. Meanwhile, globalization has been opening up opportunities for new forms of organization and institutional innovation. The outcome, the author argues, will be determined by how key actors in the world of work respond to the marginalized workers of the world.
Shaping the future of industrial relations in the EU: Ideas, paradoxes and drivers of change
Authors: KEUNE Maarten 
Published: April 2015

AbstractThe author argues that Europe's future industrial relations will be shaped by the resolution of three paradoxes embedded in today's labour markets, unionization dynamics, and EU policy. The first is the increasing individualization of employment relationships versus fictional “individual autonomy” and workers' growing market dependency and vulnerability. The second centres on the deterioration of job quality and precarious workers' growing need for protection versus their low unionization and the failure of unions to reach out to them despite declining membership. The third is the EU's current market‐oriented stance, encouraging employment conditions ultimately conducive to a political backlash against the EU itself.
Resting energy expenditure in obese children aged 4 to 15 years: Measured versus predicted data
Authors: Schmelzle H , Schröder C , Armbrust S , Unverzagt S , Fusch C 
Published: April 2015

Aim: To measure the relationship of resting energy expenditure (REE) and body composition, and to compare REE data calculated from anthropometric parameters using published equations with measurements obtained by indirect calorimetry (IC) in a population of obese paediatric patients.Methods: The study included 82 healthy obese paediatric subjects (49 boys, 33 girls; body mass index 29.6 ± 5.0 kg/m2, age 11.4 ± 2.6 y, weight 72.4 ± 20.9 kg, height 155 ± 14 cm). REE was measured by IC, body composition was determined by dual energy X‐ray absorptiometry (DXA). Bootstrap analysis was performed to validate the step‐down linear regression analysis results.Results: Lean body mass (LBM) and weight were identified as the most significant determinants of REE. LBM was the best single predictor (r= 0.78; p < 0.001) for REE. Regression equations are given in the text. Prediction of REE on the basis of published anthropometric formulas was strongly dependent from the equation used. Some equations tend to underestimate REE in the population studied with a considerable systematic error.Conclusion: In the present paper we show that (1) the published equations to predict REE in obese subjects yield scattered data and some are even biased by a systematic error, and that (2) the inclusion of DXA‐derived LBM improves accuracy and precision of predicted REE in boys and girls aged from 4 to 10 y and in boys from 11 to 15 y.
Accurate Determination of Sr Isotopic Compositions in Clinopyroxene and Silicate Glasses by LA‐MC‐ICP‐MS
Authors: Tong Xirun , Liu Yongsheng , Hu Zhaochu , Chen Haihong , Zhou Lian , Hu Qinghai , Xu Rong , Deng Lixu , Chen Chunfei , Yang Lu , Gao Shan 
Published: April 2015

The low‐Sr content (generally < 100 μg g−1) in clinopyroxene from peridotite makes accurate Sr isotopic determination by LA‐MC‐ICP‐MS a challenge. The effects of adding N2 to the sample gas and using a guard electrode (GE) on instrumental sensitivity for Sr isotopic determination by LA‐MC‐ICP‐MS were investigated. Results revealed no significant sensitivity enhancement of Sr by adding N2 to the ICP. Although using a GE led to a two‐fold sensitivity enhancement, it significantly increased the yield of polyatomic ion interferences of Ca‐related ions and TiAr+ on Sr isotopes. Applying the method established in this work, 87Sr/86Sr ratios (Rb/Sr < 0.14) of natural clinopyroxene from mantle and silicate glasses were accurately measured with similar measurement repeatability (0.0009–0.00006, 2SE) to previous studies but using a smaller spot size of 120 μm and low‐to‐moderate Sr content (30–518 μg g−1). The measurement reproducibility was 0.0004 (2s, n = 33) for a sample with 100 μg g−1 Sr. Destruction of the crystal structure by sample fusion showed no effect on Sr isotopic determination. Synthesised glasses with major element compositions similar to natural clinopyroxene have the potential to be adopted as reference materials for Sr isotopic determination by LA‐MC‐ICP‐MS.