bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Investigation of Impact of Metacentric Height on Imo Standard Maneuvers With the Use of Free Running Models
Authors: Kołodziej Radosław , Reichel Maciej 
Published: June 2024

Abstract

According to the International Maritime Organization (IMO) the maneuverability of the ship should be assessed on the basis of the standard trial maneuvers. During design process, free running model tests are considered as a reliable prediction method. Although roll motions of the maneuvering ship play an important role in navigation safety, it is a common practice that the roll-coupling effect on maneuvering is not taken into consideration during initial predictions of ship maneuvering performance. This paper presents study on impact of roll motions on the results of free running maneuvering model tests. The research was conducted using models of different types of ships and steering-propulsion systems. Each tested model was balanced for three metacentric heights so that it could achieve significantly different roll angles during maneuvering. The results are compared and the relevance of metacentric height in maneuvering prediction of ships of different size is discussed. The conclusions highlights new suggestions for class regulations and execution of free running model tests.
Clinical Characteristics and Outcomes of Patients Newly Diagnosed with Hodgkin Lymphoma: A Multicenter Descriptive Cohort Study Hodgkin Lymphoma features and outcomes in Saudi Arabia
Authors: Alalawi Mai , Alrajhi Abdullah M. , Alshahrani Walaa A , Alotaibi Amal H. , Issa Arwa Alhaj , Abumostafa Areej , Issa Zahra Alhaj , Alshehri Bashayer , Alyousif Ghadah , Alkhudair Nora , Alsuhebany Nada , Alzahrani Mohammed , Alghamdi Abrar , Alrashidi Hessah , Alenazi Batoul A. , Alonazi Shaden H. , Alghamdi Abeer A. , Vishwakarma Ramesh , Asiri Mohammed S. , Alenazi Abeer A. , Alotaibi Moureq , Sulaiman Khalid A. Al 
Published: June 2024

Abstract

Background
Hodgkin Lymphoma (HL) is a prominent B-cell neoplasm, that impacts global and Saudi populations. Given limited large-scale studies focusing on HL in Saudi Arabia, this retrospective multicenter cohort study reviewed clinical outcomes and characteristics of Saudi HL patients.
Methods
All adult patients newly diagnosed with HL at three local tertiary care hospitals from January 2016 to December 2021 were included. Patients were excluded if they were diagnosed with nodular lymphocyte-predominant HL, known to have liver cirrhosis, or received unknown chemotherapy regimens. Patient demographics, comorbidities, HL type and stage, treatment, and clinical outcomes were collected.
Results
Out of 765 screened patients, 537 with classical Hodgkin lymphoma (cHL) were included. Most patients had nodular sclerosis histopathology (81.7%) and were in stage IV (44.6%). ABVD was the primary chemotherapy treatment for cHL patients (84.9%). The overall response rate was 90.1%, with 83.6% achieved complete remission. During 12-month follow-up, 94.9% of patients were alive. Post-initial chemotherapy, 9.5% of patients experienced bleomycin-induced pulmonary toxicity, and 23.5% were hospitalized within six months. Almost 18% of patients had relapsed/refractory HL.
Conclusion
This national comprehensive study provides insights into the clinical features and outcomes of Saudi HL patients. The predominance of the nodular sclerosis subtype and high response rates to ABVD chemotherapy align with global trends, emphasizing the effectiveness of standard treatments for HL in Saudi Arabia. Monitoring patients closely remains critical for managing side effects and enhancing patient outcomes.
Pomegranate juice supplementation improves post-exercise hypotension in normal weight adults with elevated blood pressure, a single-blind, randomized parallel trial.
Authors: moradi Sajjad , mohebbi hamid , jorbonian abuzar 
Published: June 2024

Abstract

Introduction
Hypertension is a leading cause of cardiovascular mortality and morbidity. Exercise and diet are recommended as low-cost, non-pharmacological lifestyle therapeutic options to prevent and treat hypertension. In this regard, this study aimed to investigate the supplementation of pomegranate juice (POMj) with combined training on post-exercise hypotension (PEH) in young healthy, normal weight adults with elevated blood pressure.
Methods
Young healthy, normal weight adults with elevated BP (n = 16; age: 25.43 ± 2.6 years; fat%: 14.2 ± 4.4) were randomly divided into two groups of receiving 330 ml POMj and 330 ml diluted isocaloric drink with starch as placebo (PLA) one hour before each training session over the six weeks. Two weekly sessions of aerobic exercise and two sessions of resistance training were performed for 6 weeks. Aerobic exercise was performed at an intensity of 50–70% of maximum heart rate progressing from 20 to 50 minutes. Eight resistance exercises were performed at an intensity of 40–60% one-repetition maximum (1RM) for 3 sets of 10 repetitions per set with 60–90 seconds rest between sets. By what methods and why was BP measured? Post-exercise hypotension (PEH) of participants was measured before and after training. Analysis of variance and Bonferroni was used to test the hypotheses. It was hypothesized that consuming POMj with combined training would improve PEH.
Results
The results showed that there was a significant difference between the Systolic blood pressure of the POMj group and the PLA in the 30, 45 and 60 minutes (P < 0.05). Also, a significant difference in the POMj group is observed in these minutes with the pre-exercise (P < 0.05). Diastolic blood pressure did not change in any of the groups. The results showed that aerobic power increased in the POMj group, as well as a greater improvement than in the PLA group (P < 0.05).
Conclusion
According to the findings of the present study, a six-week of combined exercise with POMj improved aerobic power and PEH in young men active compared to the PLA group.
Effects of Edible Coating Treatment on Physicochemical, Sensory, and Microbial Properties to Prolong the Shelf Life of Arenga pinnata Fruit Dodol
Authors: Aulia Hasna Rahma , Daysita Lulu Eki , Pradiva Molina Indah , Puspantari Widya , Prastono Haryo 
Published: June 2024

Abstract

Dodol, a chewy and sticky dessert, is a traditional sweet treat from Indonesia with regional variations across the country. Our study investigated the shelf life enhancement of Arenga pinnata fruit dodol produced by the Argo Sumilir group through various coating treatments. The dodol samples, stored at room temperature for 30 days, underwent treatments with sorbate and ginger. We evaluated the physicochemical, sensory, and microbial properties of these samples. The results indicated that the sorbate treatment notably extended the shelf life compared to other treatments. However, the final product exhibited a moisture content exceeding 20%, which is above the recommended limit for dodol. Sensory evaluation showed that, while panelists generally appreciated the product, some found it excessively sweet. Microstructure analysis revealed a smooth but uneven surface with cavities. Overall, Arenga pinnata fruit has potential for use in dodol, but additional refinement is necessary to enhance its shelf life and texture, and to achieve the standard moisture content requirements.
Event tree analysis for risk-based assessment of digitalised condition-based maintenance in railway
Authors: Söderholm Peter , Akersteen Per-Anders 
Published: June 2024

Abstract

The purpose of this paper is to describe a risk-based scenario analysis, by use of an Event Tree Analysis (ETA) approach, which will support testability considerations and test level integration in the design or dependability improvement phases of technical systems. The proposed scenario analysis includes fault recognition and fault localization efforts and their associated hazards of false alarms, unrecognized faults, and un-localized faults. The combination of these single hazards into the hazard of NFF events and the consequences to safety, dependability, and cost are also discussed. It should be noted that the paper focuses on Built-in-Test (BIT), i.e., the capability of a test system of performing automatic fault recognition and fault localization. The hardware aspects, related to Built-in-Test Equipment (BITE), are not specifically considered. An earlier version of this paper has previously been presented at the IAI2023 Congress.
Lithium Chloride rescues Monensin-potentiated Wnt signaling inhibition in inflammatory bone loss in rats
Authors: Chagas Anderson , Gomes Sthefane , Oliveira Denis , Viana Khalil , Chaves Jennifer , Martins Conceição , Costa Vanessa , Angelino Gisele , Azevedo Sislana , Almeida Diego , Sena João Martins , Gondim Delane , Leitão Renata , Marques Mirna , Goes Paula 
Published: June 2024

Abstract

The aim of the study was to evaluate the effect of Lithium Chloride (LiCl) on animals submitted to Monensin-potentiated periodontal bone loss. For that Wistar rats were submitted to experimental periodontitis (EP) and received either 0.1ml/200g corn oil (vehicle), daily; or Monensin (Mon), receiving 10 mg/kg of Mon daily; or LiCl, receiving 150mg/kg of LiCl on alternate days; or Mon + LiCl. Naïve (N) group was not submitted to any treatment. After euthanasia, maxillae were collected for macroscopic and histological analyses, and for expression of bone markers and Wnt signaling. Molecular docking assays were used for assessing the affinity between Mon and WNT pathway components. It was seen that EP caused bone loss and inflammation in the periodontium which was potentiated by Mon. LiCl protected bone and rescued the deleterious effects of Mon marked by reduction on bone loss, increase on osteoblasts number (39%), and Runx2 (70%) and OPG (68%) gene expressions, concomitant with reduction of osteoclasts in number (32%) and function (27%). LiCL increased the gene and protein expressions of beta-catenin in animals with EP receiving Mon. In summary LiCl rescued the deleterious effect of Mon on bone in animals with EP and stands as pharmacological tool to counteract the strong inhibition of Wnt pathway. .
Effect of Fe3+ ions on the improvement of mechanical properties of MICP-reinforced calcareous sand
Authors: Wei Renjie , Zhu Jin , Peng Jie , Li Liangliang , Dai Di , Shang Zhiyang , Jiang Zhao 
Published: June 2024

Abstract

Reinforcement of calcareous sands based on microbial induced calcium carbonate precipitation (MICP) method has become a hot research topic in recent years. However, the disadvantage of MICP method is that the desired effect of improvement can only be achieved by multiple treatments of the cementing solution. In order to enhance the efficiency of MICP in reinforcing calcareous sands, an appropriate amount of iron ions was added to the cementing solution, followed by solution tests and sand column tests to assess the reinforcement effect through calcium carbonate generation, UCS and permeability coefficient. The results show that iron ions can change the morphology and size of MICP calcium carbonate in the solution test; in the sand column test, when iron ions were added to the cementing solution, the UCS of the sand column could reach up to 2832.63 kPa after five injections, and the UCS of the conventional MICP test group under the same conditions was only 185.5 kPa, and the permeability coefficient was reduced by two orders of magnitude compared with that of untreated sand. Iron ions did not increase the amount of MICP calcium carbonate in the sand column test, but changed the distribution pattern of calcium carbonate, thus increasing the strength and decreasing the permeability coefficient of the sand.
AEBP1 is a negative regulator of skeletal muscle cell differentiation in oral squamous cell carcinoma
Authors: Okazaki Fumika , Yorozu Akira , Sekiguchi Shohei , Niinuma Takeshi , Maruyama Reo , Kitajima Hiroshi , Yamamoto Eiichiro , Ishiguro Kazuya , Toyota Mutsumi , Hatanaka Yui , Nishiyama Koyo , Ogi Kazuhiro , Kai Masahiro , Takano Kenichi , Ichimiya Shingo , Miyazaki Akihiro , Suzuki Hiromu 
Published: June 2024

Abstract

The tumor microenvironment plays a pivotal role in cancer development. We recently reported that in oral squamous cell carcinoma (OSCC), adipocyte enhancer-binding protein 1 (AEBP1) is abundantly expressed in cancer-associated fibroblasts (CAFs), leading to CAF activation and inhibition of CD8 + T cell infiltration. In the present study, we investigated whether AEBP1 contributes to the destruction and atrophy of muscle tissues in OSCC. By analyzing human skeletal muscle myoblasts (HSMMs), we found that AEBP1 is downregulated during muscle cell differentiation. Transcriptome analysis revealed that AEBP1 knockdown significantly upregulates myogenesis-related genes in HSMMs, and qRT-PCR and western blot analyses confirmed the induction of muscle-related genes, including MYOG, in HSMMs after AEBP1 knockdown. Conversely, ectopic expression of AEBP1 strongly suppressed myogenesis-related genes in HSMMs. Notably, indirect co-culture of HSMMs with OSCC cells led to AEBP1 upregulation and robust suppression of muscle-related genes in HSMMs. Treatment with TGF-β1 also upregulated AEBP1 and suppressed expression of muscle-related genes in HSMMs. Our findings suggest that AEBP1 is a negative regulator of skeletal muscle cell differentiation and that OSCC cells inhibit muscle cell differentiation, at least in part, by inducing AEBP1.
Vesicouterine adherence is independent of the degree of villi implantation: A retrospective case-control study
Authors: Valentina Cheria , Ariani Grace , Priangga Bayu , Adu-Bredu Theophilus K , Duvekot Johannes J. , Aryananda Rozi Aditya 
Published: June 2024

Abstract

Background: The presence of differences between the clinical and histological classification of PAS hinders an accurate depiction of the extent of the maternal condition. None of the existing histological classification criteria are based on and correlate with surgical difficulty, morbidity risk, or maternal outcome. Methods: We conducted a case-control study of data of all PAS cases between January 2017 and December 2021 at Dr. Soetomo General Hospital, Surabaya, Indonesia. Uterine dehiscence and any cases with incomplete data were excluded from the study. After surgery, the area of abnormal adherence was marked using small pins for histological analysis. The histopathology specimens were immersed in using Hematoxylin Eosin (HE). PAS cases were divided into three groups depending on the depth of villi: accreta, increta and percreta. Primary outcome was the vesicouterine adherence. Secondary outcomes were intraoperative topography, and surgical outcome. Results: Three hundred sixty-three cases were included for analyses. Our cohort comprised of 99 accreta cases, 246 increta cases and 18 percreta cases. Estimated blood loss was significantly higher in the high-grade PAS (increta and percreta) groups than in the low-grade PAS (accreta) group (2851.0 + 2437.7 mL vs 1970.8 + 1315.8 mL; p < 0.001). Sixty-five (17.9%) cases of vesicouterine adherence were observed. This was associated with higher odds of caesarean hysterectomy (adjusted odds ratio [Adj OR] 30.77 (95% CI 12.52–75.62; p < 0.001) and bladder injury (Adj OR 7.19; 95% CI 1.94–26.64; p = 0.003) but not estimated blood loss (> 2500 mL) (Adj OR 1.06; 95% CI 0.52–2.16; p = 0.87). Cases with bladder injury had a higher estimated blood loss (p = 0.012) and concomitant caesarean hysterectomy (p < 0.001) compared to those without bladder injury. The depth of villi implantation was associated with higher blood loss (> 2500 mL) (p = 0.046) but not bladder injury (p = 0.442) and vesicouterine adherence (p = 0.503). Conclusions: Vesicouterine adherence is not associated with the depth of villi implantation, but rather with the presence of fibrosis between the bladder and uterus. These adhesions also correlated to iatrogenic bladder injuries.
Exploring the causal association between inflammatory cytokines and pancreatic cancer: a two-sample Mendelian randomized study
Authors: Huang yingjie , Yin Zhijie , Han Wei 
Published: June 2024

Abstract

Objectives
Research has revealed an association between inflammatory cytokines and the development of pancreatic cancer (PC). Nevertheless, the relationship between cause and effect remains uncertain. Our objective was to conduct a more comprehensive evaluation of the causal connection between 41 circulating inflammatory cytokines and PC.
Methods
In this research, we examined the correlation between inflammatory proteins and PC using two-sample Mendelian randomization (MR) analysis. The exposure data for genetic variation in 41 circulating inflammatory cytokines were obtained from Genome-wide Association Study (GWAS) data of individuals of European ancestry. The corresponding genetic association for PC was derived from FinnGen's GWAS data as outcome data. This research mainly utilized the IVW method, which is based on inverse variance weighting.
Results
The analysis of IVW findings indicated that SCF is associated with an increased risk of pancreatic cancer (OR: 1.39, 95% CI: 1.02–1.88; p = 0.03). On the other hand, IL-6 exhibited a beneficial safeguarding effect on pancreatic cancer (OR: 0.73, 95% CI: 0.53–0.98; p = 0.04). Analysis revealed no heterogeneity or horizontal multipotency. Other inflammatory factors did not show a clear causal link to PC.
Conclusions
This study revealed a cause-and-effect relationship between specific inflammatory factors and PC, which may provide new directions for identifying the pathogenesis of PC and effective treatment strategies involving inflammatory factors.
Dynamical behavior and density function of a stochasticSIR model with saturated incidence rate under Ornstein-Uhlenbeck process
Authors: Yang Ying , Wang Kai yuan , Zhang Jing wen , Zhang Guofang 
Published: June 2024

Abstract

In this paper, we discuss a stochastic SIR model with saturated incidence rate, which perturbed by log-normal Ornstein-Uhlenbeck (OU) process. The stability of the disease-free equilibriumand endemic equilibrium of deterministic system is initially established. Subsequently, the existenceof unique positive solutions of stochastic systems can be proved through the construction of suitableLyapunov functions. The extinction of stochastic SIR model are demonstrated by introducing thethreshold $R_0^e$. Furthermore, we study the persistence of stochastic SIR model as well as derive itsstationary distribution, and the probability density function around the quasi-endemic equilibrium iscomputed. Finally, theoretical findings are validated through numerical simulations.
Perceived Impacts of the Expanded Child Tax Credit Cessation Based on Family Income Level
Authors: Adams Elizabeth , Krovi Annika , Berquist Abigail , Mosher Peyton , Dugger Roddrick , Brickhouse Tegwyn , Bean Melanie 
Published: June 2024

Abstract

The 2021 Expanded Child Tax Credit (ECTC) lifted millions of children out of poverty and drastically improved well-being. These impacts were particularly salient for families with lower income among those who received the full ECTC benefit. This study gathered lived experiences on the ECTC cessation and explored differential impacts across income levels to inform discussions around policy restoration. Semi-structured interviews were conducted with parents who had a child (2-12 years) who received the full ECTC. Interviews occurred in May 2022 after the ECTC ended. Changes in financial security and health were assessed. Families were classified as having lower vs. higher income (LI; n=19 vs. HI; n=19) corresponding to household income below vs. above 200% of the Federal Poverty Line. Inductive analysis and constant-comparison methods generated themes on similarities/differences between groups. Results indicated families with LI experienced severe financial constraints and greater negative emotions, after the ECTC ended. Many reduced spending, budgeted, accepted financial support from family/friends, and delayed credit card payments. More families with HI reported the ECTC provided a financial buffer placingthem in a more secure position to meet current needs. Both groups reported negative impacts from inflation coinciding with the ECTC ending and minimal changes in their income tax return. Families overwhelmingly reported a desire for the ECTC to continue, despite experiencing different degrees of impact due to these financial changes. Families with LI faced greater hardships after the ECTC ended. Differences across income highlight the need for ECTC restoration, particularly for families in severely under-resourced circumstances.
Detection of A(H5N1) influenza virus nucleic acid in retail pasteurized milk
Authors: Tarbuck Natalie , Jones Jeremy , Franks John , Kandeil Ahmed , DeBeauchamp Jennifer , Miller Lance , Fabrizio Thomas , Woodard Karlie , Cochran Hannah , Foreman Bryant , Owsiany Madison , Lowe James , Webby Richard , Bowman Andrew 
Published: June 2024

Abstract

The detection of A(H5N1) clade 2.3.4.4b influenza A virus (IAV) in dairy cattle in the U.S. presents a significant threat to the economy, animal well-being, and public health. Preliminary reports of a high viral load in milk from infected cattle sparked concern regarding the safety of the commercial milk supply in the U.S.1–3 Through a convenience sampling of pasteurized milk purchased from retail stores across the United States, we detected A(H5N1) viral nucleic acid in 36.3% of samples. Viral sequencing confirmed the presence of genetic material from A(H5N1) clade 2.3.4.4b influenza A viruses. Despite the detection of relatively high levels of viral RNA, no evidence of viable virus was found following inoculation of MDCK cells, embryonated chicken eggs, or mice with positive retail milk samples. This study highlights the wider distribution of states affected by the virus than suggested by official reports, provides supporting evidence for the efficacy of pasteurization, and suggests the value of retail milk as a means to monitor continued viral evolution.
Wafer-scale monolayer organic single-crystalline films and arrays toward high-performance organic electronics
Authors: Li Rongjin , Yao Ximeng , Ma Chunli , Sun Lingjie , Wu Xianshuo , Shen Xianfeng , Wang Zhaofeng , Yang Shuyuan , Gao Pichao , Zeng Dong , Deng Wei , Jie Jiansheng , Yang Fangxu , Hu Wenping 
Published: June 2024

Abstract

Two-dimensional molecular crystals (2DMCs) stand out as a distinguished class of materials for next-generation flexible electronics, owing to their molecularly thin thickness and impeccable single-crystalline structure. However, scaling up their production without compromising the pristine single-crystalline nature has posed substantial challenges for widespread application. Herein, we introduce a novel seeded dip coating (SDC) technique that produces wafer-scale, monolayer 2DMC films with outstanding charge carrier mobility and remarkable uniformity. The SDC technique induces seeds in situ and effectively separates the nucleation and growth stages, thereby overcoming the paradoxical requirement for supersaturation of both steps. Utilizing the SDC technique, a large-area monolayer 2DMC OFET array was realized, showcasing a leading average mobility of 13.0 cm2 V− 1 s− 1 and an ultra-small mobility coefficient of variation (CV) of 7.5%. The SDC technique offers a universal and scalable pathway for producing larger-area monolayer 2DMC films, paving the way for flexible electronic applications.