bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade
Authors: Vanella Luca , Sodhi Komal , Kim Dong Hyun , Puri Nitin , Maheshwari Mani , Hinds Terry D , Bellner Lars , Goldstein Dov , Peterson Stephen J , Shapiro Joseph I , Abraham Nader G 
Published: March 2013

Abstract
Introduction
Heme oxygenase (HO), a major cytoprotective enzyme, attenuates oxidative stress and obesity. The canonical Wnt signaling cascade plays a pivotal role in the regulation of adipogenesis. The present study examined the interplay between HO-1and the Wnt canonical pathway in the modulation of adipogenesis in mesenchymal stem cell (MSC)-derived adipocytes.

Methods
To verify the role of HO-1 in generating small healthy adipocytes, cobalt protoporphyrin (CoPP), inducer of HO-1, was used during adipocyte differentiation. Lipid accumulation was measured by Oil red O staining and lipid droplet size was measured by BODIPY staining.

Results
During adipogenesis in vitro, differentiating pre-adipocytes display transient increases in the expression of genes involved in canonical Wnt signaling cascade. Increased levels of HO-1 expression and HO activity resulted in elevated levels of β-catenin, pGSK3β, Wnt10b, Pref-1, and shh along with increased levels of adiponectin (P < 0.05). In addition, induction of HO-1 resulted in a reduction in C/EBPα, PPARγ, Peg-1/Mest, aP2, CD36 expression and lipid accumulation (P < 0.05). Suppression of HO-1 gene by siRNA decreased Wnt10b, pGSK3β and β-catenin expression, and increased lipid accumulation. The canonical Wnt responsive genes, IL-8 and SFRP1, were upregulated by CoPP and their expression was decreased by the concurrent administration of tin mesoporphyrin (SnMP), an inhibitor of HO activity. Furthermore, knockdown of Wnt10b gene expression by using siRNA showed increased lipid accumulation, and this effect was not decreased by concurrent treatment with CoPP. Also our results show that blocking the Wnt 10b antagonist, Dickkopf 1 (Dkk-1), by siRNA decreased lipid accumulation and this effect was further enhanced by concurrent administration of CoPP.

Conclusions
This is the first study to demonstrate that HO-1 acts upstream of canonical Wnt signaling cascade and decreases lipogenesis and adipocyte differentiation suggesting that the HO-1 mediated increase in Wnt10b can modulate the adipocyte phenotype by regulating the transcriptional factors that play a role in adipogenesis. This is evidenced by a decrease in lipid accumulation and inflammatory cytokine levels, increased adiponectin levels and elevation of the expression of genes of the canonical Wnt signaling cascade.
Graft-Versus-Host Disease and Graft-Versus-Tumor Effects After Allogeneic Hematopoietic Cell Transplantation
Authors: Storb Rainer , Gyurkocza Boglarka , Storer Barry E. , Sorror Mohamed L. , Blume Karl , Niederwieser Dietger , Chauncey Thomas R. , Pulsipher Michael A. , Petersen Finn B. , Sahebi Firoozeh , Agura Edward D. , Hari Parameswaran , Bruno Benedetto , McSweeney Peter A. , Maris Michael B. , Maziarz Richard T. , Langston Amelia A. , Bethge Wolfgang , Vindeløv Lars , Franke Georg-Nikolaus , Laport Ginna G. , Yeager Andrew M. , Hübel Kai , Deeg H. Joachim , Georges George E. , Flowers Mary E.D. , Martin Paul J. , Mielcarek Marco , Woolfrey Ann E. , Maloney David G. , Sandmaier Brenda M. 
Published: March 2013

Purpose We designed a minimal-intensity conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) in patients with advanced hematologic malignancies unable to tolerate high-intensity regimens because of age, serious comorbidities, or previous high-dose HCT. The regimen allows the purest assessment of graft-versus-tumor (GVT) effects apart from conditioning and graft-versus-host disease (GVHD) not augmented by regimen-related toxicities. Patients and Methods Patients received low-dose total-body irradiation ± fludarabine before HCT from HLA-matched related (n = 611) or unrelated (n = 481) donors, followed by mycophenolate mofetil and a calcineurin inhibitor to aid engraftment and control GVHD. Median patient age was 56 years (range, 7 to 75 years). Forty-five percent of patients had comorbidity scores of ≥ 3. Median follow-up time was 5 years (range, 0.6 to 12.7 years). Results Depending on disease risk, comorbidities, and GVHD, lasting remissions were seen in 45% to 75% of patients, and 5-year survival ranged from 25% to 60%. At 5 years, the nonrelapse mortality (NRM) rate was 24%, and the relapse mortality rate was 34.5%. Most NRM was a result of GVHD. The most significant factors associated with GVHD-associated NRM were serious comorbidities and grafts from unrelated donors. Most relapses occurred early while the immune system was compromised. GVT effects were comparable after unrelated and related grafts. Chronic GVHD, but not acute GVHD, further increased GVT effects. The potential benefit associated with chronic GVHD was outweighed by increased NRM. Conclusion Allogeneic HCT relying on GVT effects is feasible and results in cures of an appreciable number of malignancies. Improved results could come from methods that control progression of malignancy early after HCT and effectively prevent GVHD.
Abagovomab As Maintenance Therapy in Patients With Epithelial Ovarian Cancer: A Phase III Trial of the AGO OVAR, COGI, GINECO, and GEICO—The MIMOSA Study
Authors: Sabbatini Paul , Harter Philipp , Scambia Giovanni , Sehouli Jalid , Meier Werner , Wimberger Pauline , Baumann Klaus H. , Kurzeder Christian , Schmalfeldt Barbara , Cibula David , Bidzinski Mariusz , Casado Antonio , Martoni Andrea , Colombo Nicoletta , Holloway Robert W. , Selvaggi Luigi , Li Andrew , del Campo Jose , Cwiertka Karel , Pinter Tamas , Vermorken Jan B. , Pujade-Lauraine Eric , Scartoni Simona , Bertolotti Monica , Simonelli Cecilia , Capriati Angela , Maggi Carlo Alberto , Berek Jonathan S. , Pfisterer Jacobus 
Published: March 2013

Purpose To determine whether abagovomab maintenance therapy prolongs recurrence-free (RFS) and overall survival (OS) in patients with ovarian cancer in first clinical remission. Patients and Methods Patients with International Federation of Gynecology and Obstetrics stage III to IV ovarian cancer in complete clinical remission after primary surgery and platinum- and taxane-based chemotherapy were randomly assigned at a ratio of 2:1 in a phase III, double-blind, placebo-controlled, multicenter study. Abagovomab 2 mg or placebo was administered as 1-mL suspension once every 2 weeks for 6 weeks (induction phase) and then once every 4 weeks (maintenance phase) until recurrence or up to 21 months after random assignment of the last patient. The primary end point was RFS; secondary end points were OS and immunologic response. Results Characteristics of the 888 patients included: mean age, 56.3 years; Eastern Cooperative Oncology Group performance status, ≤ 1 in > 99% of patients; serous papillary subtype, 81.5%; stage III, 85.9%; and cancer antigen 125 ≤ 35U/mL after third cycle, 80.9%. Mean exposure to study treatment (± standard deviation) was 449.7 ± 333.08 days. Hazard ratio (HR) of RFS for the treatment group using tumor size categorization (≤ 1 cm, > 1 cm) was 1.099 (95% CI, 0.919 to 1.315; P = .301). HR of OS using tumor size categorization (≤ 1 cm, > 1 cm) was 1.150 (95% CI, 0.872 to 1.518; P = .322). The most frequently reported type of adverse event was an injection site reaction in 445 patients (50.2%), followed by injection site erythema and fatigue in 227 (25.6%) and 212 patients (23.9%), respectively. By the final visit, median anti–anti-idiotypic antibody level was 493,000.0 ng/mL, indicating a robust response. Conclusion Abagovomab administered as repeated monthly injections is safe and induces a measurable immune response. Administration as maintenance therapy for patients with ovarian cancer in first remission does not prolong RFS or OS.
Sobral and its hard earned success in the international costume jewelry market
Authors: Viana Mila , Carneiro Jorge , Garrido Marcos , Peixoto Tania 
Published: March 2013

Sobral is today a major player in the resin-based costume jewelry business and is present in major international markets – France, Germany and the US – besides having a strong position in its home country, Brazil. International expansion was not carefully planned, however. The company face some dilemmas: consolidate positions in its current markets or open new frontiers? What foreign entry modes to adopt? How to overcome the lack of resources and accelerate expansion, both internationally and in Brazil? DOI: 10.12660/gvcasosv2n2c11http://dx.doi.org/10.12660/gvcasosv2n2c11
Stakeholders: fonte de informação para o planejamento de marketing
Authors: Dalfovo Michael Samir , Pavão Yeda Maria Pereira , Alberton Anete , Rossetto Carlos Ricardo , Silva Debora Pereira 
Published: March 2013

O que fazer para incorporar as necessidades dos stakeholders de uma empresa em seu plano de marketing? A Microcomp Informática vive o desafio de combinar ações estratégicas, identificação de problemas, necessidades e desejos de seus colaboradores e clientes em um mercado cada vez mais competitivo. DOI: 10.12660/gvcasosv2n2c12http://dx.doi.org/10.12660/gvcasosv2n2c12
Concessões de termoelétricas no Brasil: investir ou não?
Authors: Martits Luiz Augusto , Garcia Fábio Gallo , Amaral Júnior José Bento Carlos 
Published: March 2013

Um grupo privado brasileiro, cujo foco é investir em projetos de infraestrutura, avalia a concessão de uma usina termoelétrica. A renda da concessionária que a adquire é composta por remuneração fixa e variável. Como a remuneração variável não cobre os custos operacionais arcados pela usina, quanto menos ela operar, melhor para a concessionária. Como agir nesse caso? DOI: 10.12660/gvcasosv2n2c7http://dx.doi.org/10.12660/gvcasosv2n2c7
Ação coletiva e desenvolvimento local: o caso de Poço Verde
Authors: Caldas Eduardo de Lima , Jayo Martin 
Published: March 2013

O município de Poço Verde, em Sergipe, possui uma população rural ameaçada pela fome e insuficiência de ocupação e renda, apesar das terras disponíveis e ociosas. Quando o Governo Federal lança o Programa Nacional de Fortalecimento da Agricultura Familiar (PRONAF), a situação pode mudar, mas para receber os benefícios, os atores públicos e sociais locais precisam de um conjunto de ações articuladas. DOI: 10.12660/gvcasosv2n2c8http://dx.doi.org/10.12660/gvcasosv2n2c8
Paging Doctor Google! Heuristics vs. technology
Authors: Jhaveri Kenar D , Schrier Peter B , Mattana Joseph 
Published: March 2013

The most dramatic development in medical decision-making technology has been the advent of the Internet. This has had an impact not only on clinicians, but has also become an important resource for patients who often approach their doctors with medical information they have obtained from the Internet. Increasingly, medical students, residents and attending physicians have been using the Internet as a tool for diagnosing and treating disease. Internet-based resources that are available take various forms, including informational websites, online journals and textbooks, and social media. Search engines such as Google have been increasingly used to help in making diagnoses of disease entities. Do these search methods fare better than experienced heuristic methods? In a small study, we examined the comparative role of heuristics versus the 'Google' mode of thinking. Internal medicine residents were asked to “google” key words to come up with a diagnosis. Their results were compared to experienced nephrology faculty and fellows in training using heuristics and no additional help of internet. Overall, with the aid of Google, the novices (internal medicine residents) correctly diagnosed renal diseases less often than the experts (the attendings) but with the same frequency as the intermediates (nephrology fellows). However, in a subgroup analysis of both common diseases and rare diseases, the novices correctly diagnosed renal diseases less often than the experts but more often than the intermediates in each analysis. The novices correctly diagnosed renal diseases with the same frequency as nephrology fellows in training.
Physical optics methods for laser and nonlinear optics simulations
Authors: Wester Rolf 
Published: March 2013

Abstract
The development of optical systems today is strongly supported by computer simulations. Computer ray tracing tools are well established in the field of geometrical optics for designing objectives, light channels, etc. Ray tracing is conceptually quite simple, which makes the implementation as well as the interpretation of ray tracing results easy, although the design of high-quality lens systems remains a challenging task. In the field of wave optics, there are software tools as well, but they are still not as mature as the ray tracing tools. The main reason for this is that numerically solving partial differential equations is numerically more complex and not as intuitive as ray tracing. Besides simple wave propagation, the main field of use of the wave optics methods today is the development of lasers and laser resonator and nonlinear optics. The optical properties of the media, in general, depend on the temperature and mechanical stresses. The interaction of the electromagnetic fields with matter, thus, has to self-consistently include thermomechanical computations.
New class of multiple weights and new weighted inequalities for multilinear operators
Authors: Bui The Anh 
Published: March 2013

Abstract
In this paper, we first introduce the new class of multiple weights

A

p
→

∞

${A^\infty _{\vec{p}}}$

which is larger than the class of multiple weights in [Adv. Math. 220 (2009), 1222–1264]. Then, using this class of weights, we study the weighted norm inequalities for certain classes of multilinear operators and their commutators with new BMO functions introduced in [J. Fourier Anal. Appl. 17 (2011), 115–134]. Finally, we show that some multilinear pseudodifferential operators fall within the scope of the theory obtained in this paper.
Fractionation and characterization of lignin-carbohydrate complexes (LCCs) of Eucalyptus globulus in residues left after MWL isolation. Part II: Analyses of xylan-lignin fraction (X-L)
Authors: Miyagawa Yasuyuki , Kamitakahara Hiroshi , Takano Toshiyuki 
Published: March 2013

Abstract
The residual wood meal left after milled wood lignin (MWL) isolation [milled wood residue (MWR)] of 5-year-old Eucalyptus globulus was fractionated to afford a xylan-lignin fraction (X-L) in 2.9% yield (based on MWR) by the method reported previously. X-L was further fractionated with the lignin solvent 1,4-dioxane/water (9:1, v/v) to give a soluble fraction (XL-F1; 24.0%) and an insoluble fraction (XL-F1-residue; 74.6%; both yields based on X-L). XL-F1-residue was further extracted with the good xylan solvent dimethyl sulfoxide and the soluble fraction was termed XL-F2 (43.0%; based on the XL-F1-residue). XL-F1 was mainly composed of lignin with a small amount of xylan and it is similar to purified MWL, whereas XL-F2 was mainly composed of xylan with some amount of lignin and it is similar to a fraction that was prepared by the extraction of crude MWL with acetic acid [lignin-carbohydrate complex (LCC)-AcOH]. The two-dimensional heteronuclear single quantum coherence nuclear magnetic resonance spectra of XL-F1 and XL-F2 were interpreted that the former has α-ether-type lignin-carbohydrate (LC) linkages and the latter might have LC linkages of the phenyl glycoside type, which are different from those in LCC-AcOH.
Parental beliefs and parenting characteristics of Chinese parents experiencing economic disadvantage in Hong Kong
Authors: Leung Janet T.Y. , Shek Daniel T.L. 
Published: March 2013

Abstract
Based on the responses of 550 Chinese parents experiencing economic disadvantage in Hong Kong, the relationships between parental beliefs (including Chinese cultural beliefs on adversity, attribution of children’s success and failure to effort, and expectations of children’s future) and parenting characteristics (indexed by parenting styles and parental control) were examined in this study. More positive parental child-specific beliefs, particularly parental expectations on children’s future, were found to be associated with more positive parenting styles and stronger parental control in both paternal and maternal samples. The theoretical and practical implications of the findings are discussed.
From within and without: the virtual and the plurilingual in ELF
Authors: Hülmbauer Cornelia 
Published: March 2013

Abstract
This article explores the shifts of form and meaning involved in the use of unconventional language in English as a lingua franca (ELF). Assuming that ELF speakers as intercultural communicators are less inhibited by standardising forces than speakers in a primary lingua-cultural environment, it points to the fact that “virtual” resources, i.e., latent linguistic possibilities within English beneath the surface of the encoded, play a crucial role in the lingua franca mode. Since ELF emerges in multilingual contexts and can itself be considered a multilingual mode, the virtuality aspect is claimed to interact with elements from without English, namely plurilingual resources from the speakers’ first or other language backgrounds. While the discussion of virtual resources has thus far mainly been focused on morphological flexibility, in this article their interconnection with the plurilingual aspect of ELF is shown to also affect the dimension of meaning. It is thus argued that a valid semiotic framework of ELF needs expansion both on the morphological and on the pragmatic levels. Such an expansion acknowledges virtual and plurilingual aspects as integral parts of the lingua franca and eventually nullifies the initial distinction between influences from within and from without.
Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
Authors: Obeid Rima , Holzgreve Wolfgang , Pietrzik Klaus 
Published: March 2013

Abstract
Women have higher requirements for folate during pregnancy. An optimal folate status must be achieved before conception and in the first trimester when the neural tube closes. Low maternal folate status is causally related to neural tube defects (NTDs). Many NTDs can be prevented by increasing maternal folate intake in the preconceptional period. Dietary folate is protective, but recommending increasing folate intake is ineffective on a population level particularly during periods of high demands. This is because the recommendations are often not followed or because the bioavailability of food folate is variable. Supplemental folate [folic acid (FA) or 5-methyltetrahydrofolate (5-methylTHF)] can effectively increase folate concentrations to the level that is considered to be protective. FA is a synthetic compound that has no biological functions unless it is reduced to dihydrofolate and tetrahydrofolate. Unmetabolized FA appears in the circulation at doses of >200 μg. Individuals show wide variations in their ability to reduce FA. Carriers of certain polymorphisms in genes related to folate metabolism or absorption can better benefit from 5-methylTHF instead of FA. 5-MethylTHF [also known as (6S)-5-methylTHF] is the predominant natural form that is readily available for transport and metabolism. In contrast to FA, 5-methylTHF has no tolerable upper intake level and does not mask vitamin B12 deficiency. Supplementation of the natural form, 5-methylTHF, is a better alternative to supplementation of FA, especially in countries not applying a fortification program. Supplemental 5-methylTHF can effectively improve folate biomarkers in young women in early pregnancy in order to prevent NTDs.
ImageNets — Framework for Fast Development of Robust and High Performance Image Processing Algorithms
Authors: Lange Uwe , Kampe Henning , Gräser Axel 
Published: March 2013

Zusammenfassung
In this publication, we describe the novel ImageNets framework which enables developers with low programming knowledge to rapidly create efficient high performance image processing algorithms and which is available under an open source license. The performance of this novel tool has been compared with the simple to use Image Processing Toolbox of MATLAB/Simulink. A group of 49 students, attendees of a robot vision lecture, had to solve an image processing task using both tools. Different evaluation criteria have been measured or determined by interrogation of the students. The advantage of the new tool ImageNets has become clearly visible.
Zur physikalischen und datengetriebenen Modellbildung von Systemen mit Reibung: Methoden und Anwendung auf Kfz-Drosselklappen
Authors: Ren Zhenxing , Kroll Andreas , Sofsky Manfred 
Published: March 2013

Zusammenfassung
Dynamische Modelle sind die Grundlage für verschiedenste Analyse- und Entwurfsaufgaben. Die Modellbildung von Systemen mit signifikanten Reibeffekten stellt eine schwierige Aufgabe dar. Dazu werden im vorliegenden Beitrag Verfahren zur physikalischen und datengetriebenen Modellbildung vorgestellt und am Beispiel von Drosselklappen an Diesel-Motoren angewendet. Die Modelle werden in der HiL-Simulation für Tests von Motorsteuergeräten eingesetzt.
Effects of Daily Iron Supplementation in 2- to 5-Year-Old Children: Systematic Review and Meta-analysis
Authors: Thompson Jane , Biggs Beverley-Ann , Pasricha Sant-Rayn 
Published: March 2013

BACKGROUND AND OBJECTIVES:
Iron deficiency (ID) is the most common cause of anemia worldwide. The prevalence is highest among preschool-aged children. Iron is widely administered to children with or at risk for ID, but evidence of benefit among 2- to 5-year-old children has not been evaluated by systematic review. We summarize the evidence for the benefit and safety of daily iron supplementation with regard to hematologic, growth, and cognitive parameters in 2 to 5 year olds.

METHODS:
Electronic databases, regional databases, thesis repositories, gray literature, and references of studies and previous reviews were searched. We included randomized controlled trials that compared daily oral iron supplementation with control in 2 to 5 year olds. A random-effects meta-analysis was used to synthesize predefined outcomes reported by at least 2 studies.

RESULTS:
Of 9169 references, 15 studies met the inclusion criteria, none of which were at low risk of bias. Children receiving iron supplementation had a mean end point hemoglobin of 6.97 g/L (P &lt; .00001; I2 = 82%) greater than controls, whereas mean end point ferritin was 11.64 µg/L (P &lt; .0001; I2 = 48%) greater. No trials reported the effects of iron supplementation on ID or iron deficiency anemia, and only one reported on anemia. Limited evidence suggested that iron supplementation produced a small improvement in cognitive development but had no effect on physical growth.

CONCLUSIONS:
In 2 to 5 year olds, daily iron supplementation increases hemoglobin and ferritin. There is a concerning lack of data on the effect of iron supplementation on clinically important outcomes including anemia, ID anemia, ID, and cognitive development. Additional interventional studies in this age group are needed.