bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Furo[2,3‐d]pyridazin‐4(5H)‐one and Its N(5)‐Substituted Derivatives.
Authors: Karahan Emrah , Koza Gani , Balci Metin 
Published: April 2015

AbstractA new and efficient method for the synthesis of furopyridazinone derivatives via intramolecular cyclization reactions of 2‐hydrazonomethylfuran‐3‐carboxylate derivatives is developed.
ChemInform Abstract: Synthesis of syn‐1,3‐Aminoalcohols via a Ru‐Catalyzed N‐Demethylative Rearrangement of Isoxazolidines and Its Application in a Three‐Step Total Synthesis of HPA‐12.
Authors: Yao Chuan‐Zhi , Xiao Zu‐Feng , Ning Xiao‐Shan , Liu Jie , Zhang Xiao‐Wei , Kang Yan‐Biao 
Published: April 2015

AbstractA straightforward synthesis of syn‐1,3‐aminoalcohols as well as their N‐methyl derivatives is achieved by Ru‐catalyzed rearrangement of isoxazolidines and subsequent aminolytic or reductive ring opening.
ChemInform Abstract: A Survey of Advancements in Nucleic Acid‐Based Logic Gates and Computing for Applications in Biotechnology and Biomedicine
Authors: Wu Cuichen , Wan Shuo , Hou Weijia , Zhang Liqin , Xu Jiehua , Cui Cheng , Wang Yanyue , Hu Jun , Tan Weihong 
Published: April 2015

AbstractReview: 100 refs.
Controlling Toxicity of Peptide–Drug Conjugates by Different Chemical Linker Structures
Authors: Böhme David , Beck‐Sickinger Annette G. 
Published: April 2015

AbstractThe side effects of chemotherapy can be overcome by linking toxic agents to tumor‐targeting peptides with cleavable linkers. Herein, this concept is demonstrated by addressing the human Y1 receptor (hY1R), overexpressed in breast tumors, with analogues of the hY1R‐preferring [F7,P34]NPY. First, carboxytetramethylrhodamine was connected to [F7,P34]NPY by an amide, ester, disulfide, or enzymatic linkage. Live imaging revealed hY1R‐mediated delivery and allowed visualization of time‐dependent intracellular release. Next, the fluorophore was replaced by the toxic agent methotrexate (MTX). In addition to linkage through the amide, ester, disulfide bond, or enzymatic cleavage site, a novel disulfide/ester linker was designed and coupled to [F7,P34]NPY by solid‐phase peptide synthesis. Internalization studies showed hY1R subtype selective uptake, and cell viability experiments demonstrated hY1R‐mediated toxicity that was clearly dependent on the linkage type. Fast release profiles for fluorophore‐[F7,P34]NPY analogues correlated with high toxicities of MTX conjugates carrying the same linker types and emphasize the relevance of new structures connecting the toxophore and the carrier.
Structurally Diverse Manganese(II)–Diclofenac Complexes Showing Enhanced Antioxidant Activity and Affinity to Serum Albumins in Comparison to Sodium Diclofenac­
Authors: Zampakou Marianthi , Tangoulis Vassilis , Raptopoulou Catherine P. , Psycharis Vassilis , Papadopoulos Athanasios N. , Psomas George 
Published: April 2015

AbstractThe interactions of MnII ions with the nonsteroidal anti‐inflammatory drug sodium diclofenac in the presence of 1,10‐phenanthroline and 2,2′‐dipyridylamine lead to the formation of the trinuclear [Mn3(diclofenac)6(1,10‐phenanthroline)2(MeOH)] (1) and the mononuclear [Mn(diclofenac)2(2,2′‐dipyridylamine)] (2), respectively, which have been characterized by X‐ray crystallography. Three different coordination modes of the diclofenac ligands exist in 1, whereas the bidentate chelating mode is observed in 2. In the initial evaluation of their biological properties and potential applications, the complexes exhibited good binding propensity to human or bovine serum albumin proteins and have relatively high binding constants. The ability of the compounds to scavenge 1,1‐diphenylpicrylhydrazyl, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid), and hydroxyl radicals was evaluated, and 1 was the most‐effective scavenger among 1, 2, and sodium diclofenac.
Panchromatic Borane–aza‐BODIPY Conjugate: Synthesis, Intriguing Optical Properties, and Selective Fluorescent Sensing of Fluoride Anions
Authors: Swamy P Chinna Ayya , Priyanka Ragam N. , Mukherjee Sanjoy , Thilagar Pakkirisamy 
Published: April 2015

AbstractA new triarylborane–aza‐BODIPY conjugate is reported. The compound consists of two blue emissive dimesitylarylborane moieties and a near‐infrared (NIR) emissive aza‐BOIDPY core and shows panchromatic absorption spanning approximately 300–800 nm. DFT computational studies suggest limited electronic communication between the individual fluorophore units. Hence, the partial energy transfer from blue fluorophore triarylborane to NIR chromophore aza‐BODIPY unit leads to a broad dual‐emissive feature covering a large part of visible and NIR region. Furthermore, the broadband emissive compound can act as a selective sensor for fluoride anion as a result of fluorescence quenching response in both visible and NIR spectral regions.
Sensitive Amperometric Sensing of Hydrogen Peroxide Using Ag Nanowire Array Electrode
Authors: Kurowska‐Tabor E. , Jaskuła M. , Sulka G. D. 
Published: April 2015

AbstractThe amperometric sensor based on a silver nanowire (80 nm in diameter Ag NW) array electrode was fabricated and characterized with scanning electron microscope (SEM). The electrode showed good electrocatalytic activity for reduction of hydrogen peroxide. The effects of the applied polarization potential, pH, time interval between successive injections of analyte, injection volume and H2O2 concentration in a single injection on the electrochemical performance of the sensor were studied. It was found that the optimized operating conditions for the proposed sensor are: the potential of −200 mV, pH between 7.4 and 9.0, 60 s time interval, 10 µL injection volume, and 500 µM H2O2 in single injection. The proposed Ag NW array sensor is free of interference from ascorbic acid, uric acid and glucose.
Synthesis of Some Aminophosphonates Bearing N‐(Fluorophenyl)‐piperazynyl Moiety and Their Activity toward Serotonin Receptors
Authors: Lewkowski Jarosław , Jóźwiak Andrzej , Tokarz Paweł , Zagórski Piotr M. , Hamera Róża , Cal Dariusz , Satała Grzegorz , Bojarski Andrzej J. 
Published: April 2015

ABSTRACTSyntheses of a series of compounds bearing a 1‐(fluorophenyl)piperazin‐4‐ylmethyl moiety, namely dialkyl 1‐(fluorophenyl)piperazin‐4‐ylmethyl phosphonates 3a–f, diethyl 2‐[1‐(fluorophenyl)piperazin‐4‐yl]‐ethyl phosphonates 4a,b, diethyl 3‐[1‐(4‐fluorophenyl)‐piperazin‐4‐yl]‐propyl phosphonate 5, and di[1‐(fluorophenyl)piperazin‐4‐yl]methanes 6a,b were performed, and some of them were screened for their affinity for serotonin 5‐HT1A, 5‐HT6, and 5‐HT7 receptors. Moderate interactions with these receptors were demonstrated.
Interpretation of runoff processes in hydrological modelling—experience from the HBV approach
Authors: Bergström Sten , Lindström Göran 
Published: April 2015

AbstractThe process of development and application of the Hydrologiska Byråns Vattenbalansavdelning hydrological model over a time period of more than 40 years is reviewed and discussed. Emphasis is on the early modelling strategy and physical considerations based on contemporary research on runoff formation processes in the drainage basin. This includes areal considerations on the catchment scale, soil moisture and evapotranspiration and storages and discharge as represented by the response function of the model. The introduction of the concept of dynamic recharge and discharge areas is also addressed as well as the modelling of snow accumulation and melt. Some operational international experiences are also addressed. Copyright © 2015 John Wiley & Sons, Ltd.
Quantifying transient post‐overwash aquifer recovery for atoll islands in the Western Pacific
Authors: Bailey Ryan T. 
Published: April 2015

AbstractMarine overwash events for atoll islands in the Pacific and Indian Oceans, which cause salinization of fresh groundwater because of infiltrating seawater, pose a significant challenge for island community sustainability in regard to water supply. Understanding transient fresh groundwater development during a post‐overwash period for a range of island sizes, geologic characteristics, and rainfall patterns is essential for water management. This paper presents a methodology for quantifying this development for an atoll nation, with methods applied to the 32 atolls of the Federated States of Micronesia (FSM) in the western Pacific. Using the numerical groundwater modelling code SUTRA, overwash events and post‐overwash freshwater–seawater dynamics are simulated for the range of island widths (200 to 1100 m), geologic characteristics (hydraulic conductivity corresponding to leeward and windward islands), and rainfall patterns (western, central, and eastern regions) present in the FSM, thereby providing results for each atoll island. Results show that 10–17, 8–12, and 6–12 months are required to achieve 60% freshwater lens recovery for leeward islands in the western, central, and eastern FSM, respectively, with variation due to rainfall rate and island width. In contrast, 4–9 months is required for 60% recovery for windward islands. However, the natural thinness of the lend on windward islands typically precludes extensive use of groundwater under average rainfall conditions. Overwash characteristics (depth, duration, and seasonal timing) did not significantly affect recovery times. For the region of lowest rainfall (western FSM), 6–10 months is required to achieve potable groundwater at the typical depth of hand‐dug wells. Results provide water resource managers and atoll island communities with important information regarding timing of potential fresh groundwater use following an overwash event. Copyright © 2015 John Wiley & Sons, Ltd.
Particulate matter phagocytosis induces tissue factor in differentiating macrophages
Authors: Milano M. , Dongiovanni P. , Artoni A. , Gatti S. , Rosso L. , Colombo F. , Bollati V. , Maggioni M. , Mannucci P. M. , Bertazzi P. A. , Fargion S. , Valenti L. 
Published: April 2015

AbstractAirborne exposure to particulate matter with diameter < 10 mcM (PM10) has been linked to an increased risk of thromboembolic events, but the mechanisms are not completely understood. The aim of this study was to evaluate the effect of PM10 phagocytosis on the release of procoagulant molecules in human differentiating macrophages, and that of PM10 inhalation in an experimental model in rats. Human monocytes were separated from the peripheral blood by the lymphoprep method, differentiated in vitro and treated with standard PM10 or vehicle. Sprague–Dawley rats were instilled intratracheally with PM10 or vehicle alone. The outcome was expression of proinflammatory genes and of tissue factor (TF). In human differentiating macrophages, PM10 exposure upregulated inflammatory genes, but most consistently induced TF mRNA and protein levels, but not TF protein inhibitor, resulting in increased TF membrane expression and a procoagulant phenotype. Differentiation towards the anti‐inflammatory M2 phenotype inhibited PM10‐mediated TF expression. TF induction required phagocytosis of PM10, whereas phagocytosis of inert particles was less effective. PM10 phagocytosis was associated with a gene expression profile consistent with intracellular retention of iron, inducing oxidative stress. Both PM10 and iron activated the stress kinases ERK1/2 pathway, involved in the induction of TF expression. In rats, alveolar exposure to PM10 was associated with pulmonary recruitment of inflammatory cells and resulted in local, but not systemic, induction of TF expression, which was sufficient to increase circulating TF levels. In conclusion, TF induction by differentiating lung macrophages, activated following phagocytosis, contributes to the increased risk of thromboembolic complications associated with PM10 exposure. Copyright © 2015 John Wiley & Sons, Ltd.
Pharmacokinetics of hepatitis C virus NS5A inhibitor JNJ‐56914845 (GSK2336805) in subjects with hepatic impairment
Authors: Adkison Kimberly K. , Gan Jianjun , Elko‐Simms Lucinda , Gardner Stephen , Dumont Etienne , Jones Lori S. , Saunders Joanne , Marbury Thomas , Smith William , Berg Jolene , Galloway Christopher , Stump Patrick J. 
Published: April 2015

AbstractJNJ‐56914845 (GSK2336805) is a hepatitis C virus nonstructural protein 5A inhibitor under development for the treatment of chronic hepatitis C (CHC) infection. This open‐label, parallel‐group, 2‐part study evaluated the pharmacokinetics and safety of a single oral 60 mg dose of JNJ‐56914845 in 4 cohorts: healthy, mild, moderate, and severe hepatic impairment (n = 8/cohort). Severity of hepatic impairment was categorized using Child‐Pugh score, and the healthy subjects were matched for age, sex, body mass index, and smoking status to the moderate hepatic impairment cohort. JNJ‐56914845 plasma AUC0–∞ was 26%, 52%, and 45% lower in subjects with mild, moderate, and severe hepatic impairment, respectively, relative to healthy subjects with no difference in half‐life among the groups. The apparent oral clearance and volume of distribution were higher in subjects with hepatic impairment. The lower plasma concentrations were largely explained by decreased plasma protein binding in hepatically impaired subjects. One subject with severe hepatic impairment had 2 non‐drug‐related serious adverse events: an esophageal bleed requiring hospitalization, encephalopathy. Although hepatically impaired subjects have lower exposures than healthy matched controls, they had similar or slightly higher exposures than those observed in past studies of noncirrhotic, CHC patients, suggesting that no dose adjustments for hepatic impairment will be needed.
3‐Factor‐Criticality of Vertex‐Transitive Graphs
Authors: Zhang Heping , Sun Wuyang 
Published: April 2015

AbstractA graph of order n is p ‐factor‐critical, where p is an integer of the same parity as n, if the removal of any set of p vertices results in a graph with a perfect matching. 1‐factor‐critical graphs and 2‐factor‐critical graphs are factor‐critical graphs and bicritical graphs, respectively. It is well known that every connected vertex‐transitive graph of odd order is factor‐critical and every connected nonbipartite vertex‐transitive graph of even order is bicritical. In this article, we show that a simple connected vertex‐transitive graph of odd order at least five is 3‐factor‐critical if and only if it is not a cycle.
MR‐detected changes in liver fat, abdominal fat, and vertebral bone marrow fat after a four‐week calorie restriction in obese women
Authors: Cordes Christian , Dieckmeyer Michael , Ott Beate , Shen Jun , Ruschke Stefan , Settles Marcus , Eichhorn Claudia , Bauer Jan S. , Kooijman Hendrik , Rummeny Ernst J. , Skurk Thomas , Baum Thomas , Hauner Hans , Karampinos Dimitrios C. 
Published: April 2015

PurposeTo determine changes in the bone marrow fat fraction (BMFF) in obesity after dietary intervention in comparison with changes in abdominal fat, liver fat, and serum lipids.Materials and MethodsTwenty obese (BMI 34.92 ± 3.8 kg/m2) women participated in a 4‐week dietary intervention of 800 kcal/d plus additional vegetables. They underwent anthropometric and blood value measurements before and after the intervention. Abdominal 3T MRI was performed to measure changes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volume and single‐voxel magnetic resonance spectroscopy (MRS) to measure fat content changes in the liver and L5 vertebral body.ResultsThe greatest relative change after dietary intervention was found in the liver (−40.3%), followed by VAT volume (−15.1%), serum lipids (−12.6 to −14.5%), and SAT volume (−8.5%). There were no statistically significant changes in BMFF after dietary intervention (P = 0.39), but absolute changes in the BMFF were positively associated with SAT volume (r = 0.489) and negatively associated with nonadipose tissue volume (r = –0.493) before dietary intervention.ConclusionBone marrow behaves differently compared to SAT volume, VAT volume, liver fat, and serum lipids after a 4‐week dietary intervention in obesity and BMFF changes depend on abdominal tissue volumes before intervention. J. Magn. Reson. Imaging 2015;42:1272–1280.
Safety and efficacy of a patient‐controlled bladder management system for treating urinary retention in men
Authors: Homan Harvey D. , Dmochowski Roger , Cochran James S. , Karsh Lawrence , Sherman Neil D. , Yalla Subbarao 
Published: April 2015

AimsThe CymActive™ Bladder Management System (BMS) is a self‐retaining, intraurethral catheter with a patient‐controlled magnetic valve that allows cyclical bladder filling and emptying, without external appliances. We determined the safety and efficacy of the BMS in men with urinary retention who required catheterization for more than 7 days.MethodsMen requiring continuous drainage, bladder capacity less than 300 ml, history of prostatic or urethral surgery, or urethral length outside of defined limits, were excluded. Data were collected from patient diaries and weekly visits during catheterization for up to 30 days. The primary composite endpoint assessed four outcomes: placement, post‐void residual volume (PVR) of 75 ml or less, adverse device‐related events requiring early removal, and removal.ResultsNine of 23 patients met all four criteria: eight of 18 non‐neurogenic (7/11 prior Foley users and 1/7 without Foley experience) and one of five neurogenic spinal cord injury (SCI) patients. Secondary outcomes in non‐neurogenic patients included: 17/18 successful insertions; of these, 16/17 average PVR of 75 ml; successful valve openings and closings ≥ 95% of more than 1,400 voids; and minimal leakage. Four of five SCI patients discontinued within 7 days. Cystourethroscopy after removal revealed no marked inflammation or mucosal changes.ConclusionsThis pilot study demonstrated the BMS is potentially useful, convenient, and safe for appropriate patients. A follow‐up study will better define the characteristics of patients who benefit from this device and examine whether the use of antimuscarinic agents improves outcomes. Neurourol. Urodynam. 35:630–635, 2016. © 2015 Wiley Periodicals, Inc.
Crystallographic and optical properties of (Cu, Ag)2ZnSnS4 and (Cu, Ag)2ZnSnSe4 solid solutions
Authors: Gong Weiyan , Tabata Takahiro , Takei Koji , Morihama Masaru , Maeda Tsuyoshi , Wada Takahiro 
Published: April 2015

Abstract(Cu1‐xAgx)2ZnSnS4 (CAZTS) and (Cu1‐xAgx)2ZnSnSe4 (CAZTSe) solid solutions with 0 ≤ x ≤ 1.0 were synthesized. Their crystal structures were analyzed by Rietveld refinement of X‐ray diffraction data. The refined lattice constants a of the kesterite‐type CAZTS and CAZTSe increase with Ag content (x) increasing, while their lattice constants c slightly decrease. Therefore, by increasing x, the c /a ratio decreases from 2 for Cu‐based compounds to a value lower than 1.9 for Ag‐based compounds. The band‐gap energies (Eg) of CAZTS and CAZTSe solid solutions were determined by their diffuse reflectance spectra. The reflectance edges of the CAZTS and CAZTSe shifted to the longer wavelength side with Ag content increasing at 0.0 ≤ x ≤ 0.2, while they shifted to the shorter wavelength side at 0.2 ≤ x ≤ 1.0. By increasing x, the Eg of CAZTS decreases from 1.49 eV (x=0.0) to 1.47 (x=0.2) and then increases to 2.01 eV (x=1.0); and the Eg of CAZTSe decreases from 0.98 eV (x=0.0) to 0.95 (x=0.2) and then increases to 1.34 eV (x=1.0). There is small bowing in the band gaps of the CAZTS and CAZTSe systems. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Functional Characterization and Comparison of Intercellular Communication in Stem Cell-Derived Cardiomyocytes
Authors: Marcu Irene C. , Illaste Ardo , Heuking Pernilla , Jaconi Marisa E. , Ullrich Nina D. 
Published: April 2015

Abstract
One novel treatment strategy for the diseased heart focuses on the use of pluripotent stem cell-derived cardiomyocytes (SC-CMs) to overcome the heart's innate deficiency for self-repair. However, targeted application of SC-CMs requires in-depth characterization of their true cardiogenic potential in terms of excitability and intercellular coupling at cellular level and in multicellular preparations. In this study, we elucidated the electrical characteristics of single SC-CMs and intercellular coupling quality of cell pairs, and concomitantly compared them with well-characterized murine native neonatal and immortalized HL-1 cardiomyocytes. Firstly, we investigated the electrical properties and Ca2+ signaling mechanisms specific to cardiac contraction in single SC-CMs. Despite heterogeneity of the new cardiac cell population, their electrophysiological activity and Ca2+ handling were similar to native cells. Secondly, we investigated the capability of paired SC-CMs to form an adequate subunit of a functional syncytium and analyzed gap junctions and signal transmission by dye transfer in cell pairs. We discovered significantly diminished coupling in SC-CMs compared with native cells, which could not be enhanced by a coculture approach combining SC-CMs and primary CMs. Moreover, quantitative and structural analysis of gap junctions presented significantly reduced connexin expression levels compared with native CMs. Strong dependence of intercellular coupling on gap junction density was further confirmed by computational simulations. These novel findings demonstrate that despite the cardiogenic electrophysiological profile, SC-CMs present significant limitations in intercellular communication. Inadequate coupling may severely impair functional integration and signal transmission, which needs to be carefully considered for the prospective use of SC-CMs in cardiac repair. Stem Cells 2015;33:2208–2218
Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome
Authors: Soustek Meghan S. , Baligand Celine , Falk Darin J. , Walter Glenn A. , Lewin Alfred S. , Byrne Barry J. 
Published: April 2015

AbstractBarth syndrome (BTHS) is an X‐linked metabolic disorder that causes cardiomyopathy in infancy and is linked to mutations within the Tafazzin (TAZ) gene. The first mouse model, a TAZ knockdown model (TAZKD), has been generated to further understand the bioenergetics leading to cardiomyopathy. However, the TAZKD model does not show early signs of cardiomyopathy, and cardiac pathophysiology has not been documented until 7–8 months of age. Here we sought to determine the impact of endurance training on the cardiac and skeletal muscle phenotype in young TAZKD mice. TAZKD exercise trained (TAZKD‐ET) and control exercise trained (CON‐ET) mice underwent a 35‐day swimming protocol. Non‐trained aged matched TAZKD and CON mice were used as controls. At the end of the protocol, cardiac MRI was used to assess cardiac parameters. Cardiac MRI showed that training resulted in cardiac hypertrophy within both groups and did not result in a decline of ejection fraction. TAZKD mice exhibited a decrease in respiratory complex I, III, and IV enzymatic activity in cardiac tissue compared to control mice; however, training led to an increase in complex III activity in TAZKD‐ET mice resulting in similar levels to those of CON‐ET mice. 31P magnetic resonance spectroscopy of the gastrocnemius showed a significantly lowered pH in TAZKD‐ET mice post electrical‐stimulation compared to CON‐ET mice. Endurance training does not accelerate cardiac dysfunction in young TAZKD mice, but results in beneficial physiological effects. Furthermore, our results suggest that a significant drop in intracellular pH levels may contribute to oxidative phosphorylation defects during exercise.