bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Puzzle of Empty Formal Indications: On the ‘Deferred’ Meaning of Heidegger's Language
Authors: Zoller David 
Published: July 2024

AbstractHeidegger's notion of philosophical concepts as “formal indications” is rightly viewed as a crucial development. The idea of formal indication is partly intended to answer concerns that phenomenology objectivizes conscious life. Formal indication responds—in what would become a signature feature of much of Heidegger's early work—by setting up a unique dependency of the meaning of phenomenological concepts on their “enactment” in the first‐personal life of the investigator or reader. Commentators have appropriately wondered whether this move succeeds. Yet relatively little emphasis has been placed on the potential problem of underdetermination: whether this model of deferring meaning to “enactment” leaves the reader with a sufficient understanding of the term that they know what to enact and (hopefully) gain some positive self‐understanding through it. This problem becomes more or less acute depending on how we model the “deferred meaning” of formal indication. Here I study candidate models of “deferred meaning,” including those prominent in the literature, to determine whether any are suitable to model the meaning‐structure of formal indication and stave off the underdetermination problem.
Preoperative and intraoperative tirofiban during endovascular thrombectomy in large vessel occlusion stroke due to large artery atherosclerosis
Authors: Sun Zhiqiang , Huang Shuhan , Li Wei , Yang Yi , Wu Ya , Ma Xue , Nie Ximing , Jin Wangsheng , Liu Chengchun , Li Xiaoshu , Xu Yaning , Dong Jun , Liao Yisi , Sun Binlu , Han Wenjun , Zhao Qing , Chi Huaqiao , Wang Yanjiang , Liu Liping , Zhang Meng 
Published: July 2024

AbstractBackground and purposeThe aim of this study is to investigate the efficacy and safety of preoperative versus intraoperative tirofiban in patients with large vessel occlusion (LVO) due to large artery atherosclerosis (LAA).MethodsThis is a retrospective multicenter cohort study based on the RESCUE‐RE (Registration Study for Critical Care of Acute Ischemic Stroke After Recanalization) trial enrolling patients with anterior circulation LVO classified as LAA within 24 h of onset. Patients were divided into three groups: preoperative tirofiban (PT), intraoperative tirofiban (IT), and no tirofiban (NT). Propensity score matching (PSM) was used to balance baseline characteristics. The efficacy outcomes included 90‐day functional independence (modified Rankin Scale score = 0–2) and early partial recanalization (EPR; defined as a modified Thrombolysis in Cerebral Infarction score = 1–2a). The safety outcomes included symptomatic intracranial hemorrhage (sICH).ResultsA total of 104 matched triplets were obtained through PSM. Compared with NT, PT increased 90‐day functional independence (60.8% vs. 42.3%, p = 0.008) and EPR (42.7% vs. 18.3%, p < 0.001) rate, with a tendency to increase the asymptomatic intracranial hemorrhage (aICH) proportion (28.8% vs. 18.3%, p = 0.072). Compared with IT, PT had a higher 90‐day functional independence (60.8% vs. 45.2%, p = 0.025) and EPR (42.7% vs. 20.2%, p = 0.001) rate, with no significant difference in sICH (14.4% vs. 7.7%, p = 0.122) and aICH (28.8% vs. 21.2%, p = 0.200). Compared with NT, IT had a lower 90‐day mortality rate (9.6% vs. 24.0%, p = 0.005).ConclusionsTirofiban shows good adjuvant therapy potential in acute ischemic stroke–LVO due to LAA patients. PT is associated with higher rates of EPR and better therapeutic efficacy. In addition, EPR may be a potential way to improve prognosis.
Genetic evidence of a hybrid swarm between Alpine ibex (Capra ibex) and domestic goat (C. hircus)
Authors: Brambilla Alice , Zehnder Noel , Bassano Bruno , Rossi Luca , Grossen Christine 
Published: July 2024

AbstractImproving the understanding of the causes and effects of anthropogenic hybridization is fundamental to ensure species conservation, particularly in the case of hybridization between wild species and their domestic relatives. Knowledge is missing for many species also because of a lack of appropriate tools for hybrid identification. Here, coupling genotype and phenotype analysis, we carried out an extensive investigation of ongoing hybridization in Alpine ibex Capra ibex, a mountain ungulate of conservation concern from a genetic perspective. By genotyping 63 diagnostic and 465 neutral SNPs, 20 suspected hybrids and 126 Alpine ibex without suspicious phenotype, representing 8 populations across a major part of the species distribution, we found evidence for ongoing hybridization between Alpine ibex and domestic goat. We identified different levels of hybridization including backcrosses into both Alpine ibex and domestic goat. Our results suggest a lack of reproductive barriers between the two species and good survival and reproductive success of the hybrids. Hybridization was locally intense, like a hybrid swarm, but not spread across the rest of the species distribution. Most of the hybrids were discovered in two locations in the north‐west of Italy, while random sampling of individuals from different areas did not provide evidence of recent hybridization. Our method, based on amplicon sequencing of 63 diagnostic SNPs specifically developed for this purpose, allowed us to identify hybrids and backcrosses up to the fourth to fifth generations and was suitable for genetic samples of different quality, although with varying levels of certainty regarding the exact number of generations passed since hybridization. Based on the paired analysis of genotype and phenotype, we provide guidelines for the first identification of hybrids in the field and suggest a procedure for the reliable identification of hybrids.
Theorizing Multiple Geographies: Interrelations of Space and Multiplicity in Geographical Research
Authors: Liodaki Danai , Rekhviashvili Lela , Lang Thilo , Apostolopoulou Elia 
Published: July 2024

ABSTRACTStarting from the observation that the notion of “multiple geographies” has gained considerable traction in geographical research in the past years while its theoretical foundations have often remained abstract, in this paper we contribute toward elaboration of multiple geographies as a research perspective, recognizing its potential as a valuable framework for analyzing divergent spatial relations. Initially, we provide an overview of the diverse applications of multiple geographies through a review of relevant literature, focusing on papers within the realms of political geographies that mention the term in their title or abstract. Subsequently, we categorize these papers thematically, identifying three main theoretical strains: post‐colonial geographies, uneven geographical development, and feminist geographies. We then propose a theoretical scaffold for navigating the complexities of multiple geographies by engaging with broader discussions on plurality and multiplicity in relation to the aforementioned strains. Finally, we synthesize the insights garnered from this analysis, exploring the potential of a multiple geographies research perspective to contribute to a nuanced understanding of the diverse ways in which space is produced and experienced. Our contribution aims to enrich ongoing debates within human geography on how space can be redefined in more relational, decolonial, socially just, feminist, and diverse ways, opening pathways for pluralistic geographical imaginations.
Teacher wellbeing and teaching excellence in higher education: Exploring the interplay through the lens of the PERMA framework
Authors: Golab Anna , Barratt Tom , Yong Jaime , Afroz Tanzim 
Published: July 2024

AbstractRecognising the pivotal role of teacher wellbeing in fostering teaching excellence, this paper explores the intricate relationships in the context of higher education. Employing an abductive, qualitative methodology and expanding the use of the PERMA framework to in the realm of higher education, this paper investigates the associations between teachers' perceptions of excellence to five elements of wellbeing: positive emotions (P), engagement (E), relationships (R), meaning (M) and accomplishment (A). Drawing insights from a case study of an Australian business school, the findings of this paper reveal dynamic interactions among these elements. Contextual variations give rise to virtuous or vicious cycles, allowing for the facilitation or degradation of both teacher wellbeing and teaching excellence. This underscores the interplay between the dimensions of teaching quality and wellbeing of educators in higher education, shedding light on the potential cyclical influences that can either bolster or undermine the symbiotic relationship between teacher wellbeing and excellence.
Combined peripheral blood monocyte count and white blood cell count as a guide for successful one‐day autologous peripheral blood stem cell collection
Authors: Watanaboonyongcharoen Phandee , Lorucharoen Nattarat , Wudhikarn Kitsada , Bunworasate Udomsak , Chanswangphuwana Chantiya , Rojnuckarin Ponlapat 
Published: July 2024

AbstractIntroductionPeripheral blood stem cells (PBSCs) are the most common source of stem cell transplantation, which depends on an adequate number of CD34+ cells. Although pre‐apheresis CD34+ cell count is a standard guide for the collection, it is not always available. This study aimed to evaluate complete blood count parameters for predicting successful one‐day autologous PBSC collection.MethodsData from the patients who underwent autologous PBSC collection at a tertiary care hospital were retrospectively reviewed.ResultsThere were 123 patients (185 leukapheresis procedures). Successful PBSC collection (CD34+ cells ≥4.0 × 106 cells/kg) was obtained in 85 patients (69.1%), of which 55 (44.7%) were successfully obtained on the first day. The median CD34+ collection efficiency was 44.1%. The mean platelet loss during apheresis was 39.9%. The adverse event rate was 18.9%. Patients in whom PBSCs were collected within one day were less likely to experience adverse effects related to leukapheresis. Pre‐apheresis CD34+ cells ≥10 cells/μLand combined white blood cell (WBC) counts ≥5 × 109/L and/or monocyte ≥10% were independently associated with the successful one‐day PBSC collection (adjusted odds ratio 24.06, 95% confidence interval [CI] 5.30–109.10, p < 0.001; and 6.94, 95% CI 1.35–35.79, p = 0.021, respectively). Only pre‐apheresis CD34+ cells had a strong correlation with the total stem cell yield.ConclusionsTo reduce the complication of leukapheresis, the combined pre‐apheresis WBC ≥5 × 109/L and/or monocyte ≥10% is a practical parameter to initiate a successfully one‐day PBSC collection with or without pre‐apheresis CD34+ cell results.
Trifecta outcomes of robotic partial nephrectomy in obese patients: A comparison of body mass index <25, 25 to <30, and ≥30
Authors: Ohsugi Haruyuki , Ikeda Junichi , Takayasu Kenta , Takizawa Nae , Taniguchi Hisanori , Yanishi Masaaki , Kinoshita Hidefumi 
Published: July 2024

ObjectiveWe analyzed robotic partial nephrectomy (RPN) outcomes in obese patients based on body mass index (BMI) and trifecta achievement.MethodsWe retrospectively reviewed 296 patients who underwent RPN at Kansai Medical University Hospital between 2014 and 2022. The preoperative clinical data and perioperative outcomes were evaluated. Trifecta achievement (negative surgical margin, no major complications, and no acute kidney injury on postoperative day three) and its relationship to three BMI groups (<25, 25 to <30, and ≥30) were the primary outcome. The correlation between factors in achieving trifecta and BMI was evaluated. Univariate and multivariate analyses assessed variables for achieving the trifecta with logistic regression analysis. C‐statistics quantitatively evaluated the prediction accuracy.ResultsAmong 296 patients, 264 (89.2%) achieved trifecta (BMI categories were <25 [89.9%], 25 to <30 [89.4%], and ≥30 [82.6%]). There was no significant BMI‐related difference (p = 0.566). Intraoperative blood loss increased with the BMI (p = 0.034). Multivariate analyses showed preoperative aspects and dimensions used for anatomic (PADUA) score independently predicted trifecta failure (odds ratio 1.71; 95% confidence interval 1.32–2.20;p < 0.001). The C‐statistics of the PADUA score increased with increasing BMI.ConclusionsHigher BMI patients had more intraoperative blood loss during RPN. However, RPN remains safe and has acceptable quality and functional outcomes. Since patients with high PADUA scores combined with a high BMI may be at risk of trifecta failure, this should be explained before RPN.
Optimising the structure of outpatient clinic letters: insights from a survey of general practitioners and hospital doctors
Authors: Jayawardena Thisuri , Lei Cory , McLeod Katie , Chakera Aron 
Published: July 2024

AbstractOutpatient letters are an essential communication tool in healthcare. Yet doctors receive little training on letter writing and what details recipients consider important. We surveyed 106 hospital doctors and 63 general practitioners (GPs), identifying differences in each group's preferences; GPs preferred more structured, detailed letters. Opportunities for feedback, formal templates and advanced software systems can improve communication in outpatient clinics.
People Living With Mental Illness Perceptions of Physical Health, Mental Health and Well‐Being
Authors: Porter Cassandra , Aggar Christina , Duncanson Kerith 
Published: July 2024

ABSTRACTUnderstanding the perspectives of regional people living with mental illness is crucial to adapting services, improving holistic care and meeting individual needs. This study explored people living with mental illness perceptions of physical health, mental health and well‐being. A descriptive qualitative study design underpinned by empowerment theory was conducted. Qualitative data were collected verbally via semi‐structured interviews, with demographic details provided verbally at the end of the interview. Thematic analysis was utilised to identify themes. The COREQ checklist was used for reporting. Fourteen participants admitted to regional mental health inpatient units aged between 25 and 84 years old were interviewed. Participants felt their overall well‐being was good despite feeling their physical health or mental health was suboptimal, suggesting that their perceived well‐being is influenced by factors beyond their physical and mental health. Most participants reported looking after their physical health, mental health and well‐being and identified various behavioural lifestyle strategies they found helpful. Thematic analysis identified three themes: functioning well, feeling in control and meeting basic needs. Mental health services and clinicians play an important role in empowering people with mental illness to improve their physical health, mental health and well‐being while admitted to inpatient services; however, it is acknowledged resources can be limited. Mental health services may consider referring people with mental illness to social prescribing programmes to meet their individualised needs on discharge.
Family Caregivers' Perceptions and Experiences of Supporting Older People to Cope With Loneliness: A Qualitative Interview Study
Authors: Cheng Ka Man , Zhao Ivy Yan , Maneze Della , Holroyd Eleanor , Leung Angela Yee Man 
Published: July 2024

ABSTRACTLoneliness has become a significant public health issue among community‐dwelling older adults particularly those with multimorbidity. Family caregivers are crucial care resources for dependent older adults living in the community before transitioning to institutional services. However, understanding of their perceptions in supporting older adults with multimorbidity to cope with loneliness is limited. This qualitative study aimed to elucidate on the experiences of caring and explore the experiences and perceptions of family caregivers in supporting older community‐dwelling adults with multimorbidity to cope with loneliness. Eleven family caregivers, aged 51–93 years old, with at least 2 years of caregiving experience were purposively recruited and interviewed individually. The Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist was utilised to report the study. Three key themes were generated from the inductive analysis: (1) recognising older adults' loneliness through the expression of unusual emotions, behaviour/s, social network alteration and speech; (2) variations in perceptions and responses to loneliness among different family caregiving relationships; and (3) challenges in addressing loneliness. Positive feedback from cared‐for older adults was appreciated by their family caregivers which in turn motivated further actions to alleviate loneliness. The findings emphasised the importance of developing specific patients and family caregivers centred interventions, such as communication skills training to enhance effective communications. Cultural values and norms of individuals should be respected in those interventions, ensuring that emotional expression is facilitated in a comfortable way for both older patients and family caregivers.
Community health services in European literature: A systematic review of their features, outcomes, and nursing contribution to care
Authors: Caponnetto Valeria , Dante Angelo , El Aoufy Khadija , Melis Maria Ramona , Ottonello Giulia , Napolitano Francesca , Ferraiuolo Fabio , Camero Francesco , Cuoco Angela , Erba Ilaria , Rasero Laura , Sasso Loredana , Bagnasco Annamaria , Alvaro Rosaria , Manara Duilio Fiorenzo , Rocco Gennaro , Zega Maurizio , Cicolini Giancarlo , Mazzoleni Beatrice , Lancia Loreto 
Published: July 2024

AbstractBackgroundTo meet the population's needs, community care should be customized and continuous, adequately equipped, and monitored.IntroductionConsidering their fragmented and heterogeneous nature, a summary of community healthcare services described in European literature is needed. The aim of this study was to summarize their organizational models, outcomes, nursing contribution to care, and nursing‐related determinants of outcomes.MethodsA systematic review was performed by searching PubMed, CINAHL, Scopus, and Embase in October 2022 and October 2023 (for updated results). Quantitative studies investigating the effects of community care, including nursing contribution, on patient outcomes were included and summarized. Reporting followed the PRISMA checklist. The review protocol was registered on PROSPERO (CRD42022383856).ResultsTwenty‐three studies describing six types of community care services were included, which are heterogeneous in terms of target population, country, interventions, organizational characteristics, and investigated outcomes. Heterogeneous services’ effects were observed for access to emergency services, satisfaction, and compliance with treatment. Services revealed a potential to reduce rehospitalizations of people with long‐term conditions, frail or older persons, children, and heart failure patients. Models are mainly multidisciplinary and, although staffing and workload may also have an impact on provided care, this was not enough investigated.DiscussionCommunity health services described in European literature in the last decade are in line with population needs and suggest different suitable models and settings according to different care needs. Community care should be strengthened in health systems, although the influence of staffing, workload, and work environment on nursing care should be investigated by developing new management models.Conclusions and implications for health policyCommunity care models are heterogeneous across Europe, and the optimum organizational structure is not clear yet. Future policies should consider the impact of community care on both health and economic outcomes and enhance nursing contributions to care.
The information effect versus governance effect of comment letters: Evidence from the cost of equity capital
Authors: Chen Yikun , Hu Ning , Cao Yanan , Guo Savannah (Yuanyuan) , Wang Yuhan 
Published: July 2024

AbstractThis paper uses a sample of comment letters issued and disclosed by the Shanghai and Shenzhen Stock Exchanges in China from 2015 to 2019 and empirically investigates the impact of comment letters on the cost of equity capital. The results show that the cost of equity capital raises after firms receive comment letters. However, when repeating the analysis using comment letters issued but undisclosed between 2013 and 2014, the observed effect dissipates, indicating an information disclosure channel. Moreover, the cost of equity capital is higher when the letters include more questions and demand independent opinions from auditors. Cross‐sectional tests show that this effect is influenced by investor protection, corporate information environment, and internal control quality. Additional tests show a negative association between the receipt of comment letters and both the likelihood and the amount of seasoned equity offerings, which can be attributed to the elevated cost of equity. Overall, our paper not only underscores the importance of public disclosure of government regulatory information, but also provides empirical evidence supporting the effectiveness of regulation by stock exchanges.
An exploration of nursing students' lived experience of clinical placement in adult male prisons: A phenomenological study
Authors: Brooke Joanne , Rybacka Monika , Sarwan Shubhangi , Ojo Omorogieva 
Published: July 2024

AbstractAimTo explore nursing students' lived experience of a clinical placement within healthcare in a prison, to gain an insight into the support provided prior to and during this unique clinical placement.DesignAn inductive phenomenological study.MethodsParticipants included 14 nursing students from three undergraduate nursing programmes in England, Adult (n = 4), Learning Disability (n = 3) and Mental Health (n = 7). Following a clinical placement in a prison, each participant completed a semistructured audio‐recorded interview on MS Teams between October and December 2021. Audio recordings were transcribed verbatim and thematic analysis was completed.ResultsTwo overarching themes were identified, ‘shock’ due to the (a) reality of prison; (b) overwhelming emotional impact and (c) frequency and severity of self‐harm and ‘surprise’ due to (a) the need to work with prison officers; (b) recognizing and addressing preconceptions of people in prison and (c) the development of clinical knowledge, skills and becoming a nurse.ConclusionsThe need remains for a comprehensive strategy of preparation and orientation for nursing students before commencing a clinical placement in prison, which includes the development of knowledge and clinical skills to support the complex health and social care needs of people in prison.ImpactOur research identified the support provided to nursing students prior to clinical placement in prison varies considerably. The development of a preparation and orientation programme has the potential to reduce pre‐placement anxiety, emotional burden and support nursing students in addressing their preconceptions of people in prison. This approach is essential to support future nursing students to embrace the unique opportunity of a clinical placement within a prison, enhance their clinical knowledge and skills, and develop as a nurse.Reporting MethodOur paper adheres to the consolidated criteria for reporting qualitative research (COREQ).Patient or Public Contribution to the Development of this StudyNone.