bluuebunny/crossref_metadata_2025_split huggingface dataset:
The exosphere of Mars can be tracked by a high-spectral resolution telescope, such as the Line Emission Mapper
Authors: Carter Jennifer A , Dennerl K , Kuntz K D , Dunn W , Bodewits D , Jackman C M , Sembay S F , Branduardi-Raymont G , Deskins T , Koutroumpa D , Kraft R , Lisse C , McEntee S , Wolk S , Porter F S 
Published: August 2024

Abstract
Mars provides our local analogue for unmagnetized terrestrial planets and is thus key to understanding the habitability of exoplanets. The lack of a global magnetic field means that the atmosphere interacts directly with the solar wind, causing significant loss of the atmosphere. While in situ measurements provide a wealth of detailed local information, they are limited in deriving the global picture. In contrast, remote X-ray observations can provide important global instantaneous coverage over multiple seasons and sampling different solar wind. Previous XMM–Newton observations have detected significant flux via the solar wind charge exchange emission (SWCX) mechanism from an extended planetary halo, and from atmospheric fluorescence. In contrast, Chandra observations only detected a low-luminosity disc and a faint halo. It is postulated that these observational differences are due to transient solar wind with increased heavy ion fractions. Here, we present simulated spectra for the proposed NASA mission Line Emission Mapper, of both halo and disc regions, under quiet and transient solar wind. We show that even under moderate solar wind conditions, both SWCX and fluorescence emission lines are readily detected above the background, providing new insights into the loss of planetary atmospheres and the molecular composition of less well-characterized atmospheric abundances.
Empirical Investigation of a Sufficient Statistic for Monetary Shocks
Authors: Alvarez Fernando , Ferrara Andrea , Gautier Erwan , Le Bihan Hervé , Lippi Francesco 
Published: August 2024

Abstract
In a broad class of sticky-price models, the non-neutrality of nominal shocks is captured by a simple sufficient statistic: the ratio of the kurtosis of the price change distribution over the frequency of price changes. We test the sufficient statistic proposition using data for a large sample of products representative of the French economy. We first extend the theory to allow for empirically relevant monetary shocks with a transitory predictable component. We then use the microdata to measure kurtosis and frequency for about 120 producer price indices industries and 220 consumer price indices categories. We use a Factor-Augmented Vector Autoregressive (FAVAR) model to measure the industries’ response to monetary shocks, under alternative identification schemes. The estimated degree of non-neutrality correlates with the kurtosis and the frequency consistently with the predictions of the theory. Several robustness checks are discussed.
A predictive model for progression to clinical arthritis in at-risk individuals with arthralgia based on lymphocyte subsets and ACPA
Authors: Prajzlerová Klára , Kryštůfková Olga , Kaspříková Nikola , Růžičková Nora , Hulejová Hana , Hánová Petra , Vencovský Jiří , Šenolt Ladislav , Filková Mária 
Published: August 2024

Abstract

Background
The presence of ACPA significantly increases the risk of developing RA. Dysregulation of lymphocyte subpopulations was previously described in RA. Our objective was to propose the predictive model for progression to clinical arthritis based on peripheral lymphocyte subsets and ACPA in individuals who are at risk of RA.

Methods
Our study included 207 at-risk individuals defined by the presence of arthralgias and either additional ACPA positivity or meeting the EULAR definition for clinically suspect arthralgia. For the construction of predictive models, 153 individuals with symptom duration ≥12 months who have not yet progressed to arthritis were included. The lymphocyte subsets were evaluated using flow cytometry and anti-CCP using ELISA.

Results
Out of all individuals with arthralgia, 41 progressed to arthritis. A logistic regression model with baseline peripheral blood lymphocyte subpopulations and ACPA as predictors was constructed. The resulting predictive model showed that high anti-CCP IgG, higher percentage of CD4+ T cells, and lower percentage of T and NK cells increased the probability of arthritis development. Moreover, the proposed classification decision tree showed that individuals having both high anti-CCP IgG and low NK cells have the highest risk of developing arthritis.

Conclusions
We propose a predictive model based on baseline levels of lymphocyte subpopulations and ACPA to identify individuals with arthralgia with the highest risk of progression to clinical arthritis. The final model includes T cells and NK cells, which are involved in the pathogenesis of RA. This preliminary model requires further validation in larger at-risk cohorts.
Public opinion and expert critique: reconsidering the role of constitutional scholars in Japan’s security policy
Authors: Iseki Tatsuya , Shinomoto Sou 
Published: August 2024

Abstract
Do experts’ opinions influence public opinion? Although experts with academic backgrounds are gaining a presence in policy debates, empirical studies deliver inconclusive results on whether experts have a cueing effect. Moreover, while most studies focus on cases where experts propose or recommend policies, the influence of their criticism on government policy has not received much research attention. To fill this gap, through an online survey in Japan, we test the effect of constitutional scholars’ criticism on people’s support for a dispatch of the Japan Self-Defense Forces (JSDF). Since constitutional academics, regarded as influential experts, have historically criticized the constitutional legitimacy of Japan’s security policy, they provide a suitable case to examine. The results show that such criticism has no causal effect on public attitudes even among the most liberal respondents or those with high confidence in constitutional scholars. Contrary opinions from retired general officers decreased support for the dispatch among individuals who were conservative or had high confidence in the JSDF. These findings imply that though people consciously sift through information from different sources, they mostly reject the opinions of academic experts.
Testicular prostheses: a historical and current review of the literature
Authors: Matthew-Onabanjo Asia N , Honig Stanton 
Published: August 2024

Abstract

Introduction
Testicular prosthesis can be placed at the time of orchiectomy for many benign and malignant testicular conditions. The American Urological Association guidelines recommend discussing the implant prior to the procedure.

Objectives
We review the literature on testicular prosthesis placement with respect to the history, psychological impact, surgical technique, complications, satisfaction, and novel emerging medical implications.

Methods
A Medline search was conducted with several terms related to and including “testicular implant,” “testicular prosthesis,” “testicular implant satisfaction,” and “testicular implant history.” Twenty articles were identified with patient satisfaction data. Satisfaction with the comfort, shape, size, and weight was reported in addition to satisfaction with the device from 13 studies.

Results
Overall satisfaction of testicular prosthesis is reported as high. Patients should be offered an implant at the time of orchiectomy or at any subsequent time based on their preference.

Conclusion
This article presents a contemporary and comprehensive review of the literature on testicular prostheses. Satisfaction rates following implantation remain consistently high. Additionally, innovative approaches are being investigated, including the exploration of novel implants for treating hypogonadism. Moreover, the utilization of 3-dimensional printing technology is revolutionizing the creation of testicular implants, aiming to achieve a texture and density closely resembling human testicles.
“The Explosive Ingredients Are Here” Mexican American Municipal Electoral Challenges in South Texas, 1963–1965
Authors: Campney Brent M S 
Published: August 2024

Abstract
This article examines the unsettled landscape of racial and political relations between and among Mexican Americans and Anglos in South Texas from 1963 to 1965, as liberal Mexican American civil rights activists organized to challenge longstanding Anglo power, driving fear, anger, and backlash among Anglos and exacerbating divisions among Mexican Americans across lines of class and ideology. In three sections, the work investigates a series of threatened, attempted, and successful municipal electoral challenges by Mexican American voters beyond the well-known and widely publicized such event in Crystal City in 1963. In the first section, the study details the embryonic municipal electoral challenges that erupted before and after Crystal City between 1963 and 1965, showing that Mexican American South Texans supported the overthrow of Anglo political domination. In the second, it sketches the responses of Anglos to what they termed “Latin take-overs,” reflecting the erosion of Anglo dominance. In the third, it examines how the electoral challenges mounted by Mexican Americans revealed internecine ideological and class divisions amongst themselves over the most effective ways to challenge racism, demonstrating the conflicts that undermined their efforts and strengthened those of the Anglos. In so doing, the study challenges and revises the historiography of the Crystal City ‘revolt’ and its legacies.
6Economic Criticism
Authors: Stallings Camille L 
Published: August 2024

Abstract
This year’s review of work in economic criticism focuses on three points of interest that reflect the year’s work in economic theory, providing an overview of some of the broader critical enquiries preoccupying the field of economic writing in 2023 and early 2024. The first is the intersection of animal studies and Marxism, exemplified by Leigh Claire La Berge’s Marx for Cats: A Radical Bestiary. The second key aspect of economic writing this year is the overlapping concerns of women, money, and property, represented here in Lana L. Dalley’s edited collection, Women’s Economic Writing in the Nineteenth Century and Jill Rappoport’s Imagining Women’s Property in Victorian Fiction. The third focus lands on speculative time and futurity within the domain of American literature, capitalism, and finance, as Paul Crosthwaite’s Speculative Time: American Literature in an Age of Crisis astutely captures.
Timing of intercontinental faunal migrations: Anguimorph lizards from the earliest Eocene (MP 7) of Dormaal, Belgium
Authors: Čerňanský Andrej , Smith Richard , Smith Thierry , Folie Annelise 
Published: August 2024

Abstract
Here we report on anguimorph lizards from the earliest Eocene (MP 7) of the Dormaal locality in Belgium, from the time of the warmest global climate of the past 66 million years. Several clades can be identified in this site: Glyptosauridae, Varanidae, and Palaeovaranidae. Our study focuses on glyptosaurid specimens previously reported from the site, some of which had been provisionally described as a new species,?Placosaurus ragei, and some assigned to an unnamed Placosauriops-like ‘melanosaurine’. Our study presents data on new material, including an almost complete glyptosaurine frontal that has enabled us to assign much of the previously described material to a single genus and species. The specimens that had been assigned to both ?P ragei and the ‘melanosaurine’ share apomorphies (flat osteoderms and chevron-shaped osteoderms) with Gaultia, a glyptosaurid previously known from the earliest Eocene of Wyoming, USA. The Dormaal material represents the first record of this genus outside North America. In fact, the only potential evidence of the occurrence of ‘Melanosaurinae’ in Dormaal might be a single isolated vertebra described here. Here we also describe previously unfigured material of Saniwa and palaeovaranids from Dormaal. The presence of previously reported helodermatids cannot be supported in this Belgian site.
Hypoxia‐inducible factor‐1α can reverse the Adriamycin resistance of breast cancer adjuvant chemotherapy by upregulating transferrin receptor and activating ferroptosis
Authors: Yu Xiaojie , Guo Qingqun , Zhang Haojie , Wang Xiaohong , Han Yong , Yang Zhenlin 
Published: August 2024

AbstractBreast cancer is a common malignant tumor in women. Ferroptosis, a programmed cell death pathway, is closely associated with breast cancer and its resistance. The transferrin receptor (TFRC) is a key factor in ferroptosis, playing a crucial role in intracellular iron accumulation and the occurrence of ferroptosis. This study investigates the influence and significance of TFRC and its upstream transcription factor hypoxia‐inducible factor‐1α (HIF1α) on the efficacy of neoadjuvant therapy in breast cancer. The differential gene obtained from clinical samples through genetic sequencing is TFRC. Bioinformatics analysis revealed that TFRC expression in breast cancer was significantly greater in breast cancer tissues than in normal tissues, but significantly downregulated in Adriamycin (ADR)‐resistant tissues. Iron‐responsive element‐binding protein 2 (IREB2) interacts with TFRC and participates in ferroptosis. HIF1α, an upstream transcription factor, positively regulates TFRC. Experimental results indicated higher levels of ferroptosis markers in breast cancer tissue than in normal tissue. In the TAC neoadjuvant regimen‐sensitive group, iron ion (Fe2+) and malondialdehyde (MDA) levels were greater than those in the resistant group (all p < .05). Expression levels of TFRC, IREB2, FTH1, and HIF1α were higher in breast cancer tissue compared to normal tissue. Additionally, the expression of the TFRC protein in the TAC neoadjuvant regimen‐sensitive group was significantly higher than that in the resistant group (all p < .05), while the difference in the level of expression of IREB2 and FTH1 between the sensitive and resistant groups was not significant (p > .05). The dual‐luciferase assay revealed that HIF1α acts as an upstream transcription factor of TFRC (p < .05). Overexpression of HIF1α in ADR‐resistant breast cancer cells increased TFRC, Fe2+, and MDA content. After ADR treatment, the cell survival rate decreased significantly, and ferroptosis could be reversed by the combined application of Fer‐1 (all p < .05). In conclusion, ferroptosis and chemotherapy resistance are correlated in breast cancer. TFRC is a key regulatory factor influenced by HIF1α and is associated with chemotherapy resistance. Upregulating HIF1α in resistant cells may reverse resistance by activating ferroptosis through TFRC overexpression.
Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis
Authors: Gao Xiang , Gao Ning , Du Miaomiao , Xiang Yongguo , Zuo Hangjia , Cao Huijie , Zheng Shijie , Huang Rongxi , Wan Wenjuan , Hu Ke 
Published: August 2024

AbstractThe ciliary muscle constitutes a crucial element in refractive regulation. Investigating the pathophysiological mechanisms within the ciliary muscle during excessive contraction holds significance in treating ciliary muscle dysfunction. A guinea pig model of excessive contraction of the ciliary muscle induced by drops pilocarpine was employed, alongside the primary ciliary muscle cells was employed in in vitro experiments. The results of the ophthalmic examination showed that pilocarpine did not significantly change refraction and axial length during the experiment, but had adverse effects on the regulatory power of the ciliary muscle. The current data reveal notable alterations in the expression profiles of hypoxia inducible factor 1 (HIF‐1α), ATP2A2, P53, α‐SMA, Caspase‐3, and BAX within the ciliary muscle of animals subjected to pilocarpine exposure, alongside corresponding changes observed in cultured cells treated with pilocarpine. Augmented levels of ROS were detected in both tissue specimens and cells, culminating in a significant increase in cell apoptosis in in vivo and in vitro experiments. Further examination revealed that pilocarpine induced an increase in intracellular Ca2+ levels and disrupted MMP, as evidenced by mitochondrial swelling and diminished cristae density compared to control conditions, concomitant with a noteworthy decline in antioxidant enzyme activity. However, subsequent blockade of Ca2+ channels in cells resulted in downregulation of HIF‐1α, ATP2A2, P53, α‐SMA, Caspase‐3, and BAX expression, alongside ameliorated mitochondrial function and morphology. The inhibition of Ca2+ channels presents a viable approach to mitigate ciliary cells damage and sustain proper ciliary muscle function by curtailing the mitochondrial damage induced by excessive contractions.
Neuropeptide Y Y2 Receptors in Sensory Neurons Tonically Suppress Nociception and Itch but Facilitate Postsurgical and Neuropathic Pain Hypersensitivity
Authors: Basu Paramita , Maddula Akshitha , Nelson Tyler S. , Prasoon Pranav , Winter Michelle K. , Herzog Herbert , McCarson Kenneth E. , Taylor Bradley K. 
Published: August 2024

Background:
Neuropeptide Y (NPY) Y2 receptor (Y2) antagonist BIIE0246 can both inhibit and facilitate nociception. We hypothesized that Y2 function depends on inflammation or nerve injury status.

Methods:
We implemented a battery of behavioral tests in mice of both sexes that received: 1) no injury; 2) an incision model of postoperative pain; 3) a spared nerve injury (SNI) model of neuropathic pain; and 4) a latent sensitization model of chronic postsurgical pain. In addition to Y2 gene expression assays, spinal Y2 G-protein coupling was studied with [ 35S]GTPγS binding assays.

Results:
We report that intrathecal BIIE0246 increased mechanical and cold hypersensitivity, produced behavioral signs of spontaneous nociception and itch, and produced conditioned place aversion and preference in normal, uninjured mice. BIIE0246 did not change heat hypersensitivity or motor coordination. Conditional (sensory neuron-specific) Y2 deletion prevented BIIE0246-induced mechanical and cold hypersensitivity, nocifensive behaviors and aversion. Both conditional deletion and pharmacological blockade of Y2 reduced mechanical and thermal hypersensitivity after incision or nerve injury. SNI did not change the sensitivity of Y2 G-protein coupling with the Y2 agonist PYY3-36, but increased the population of Y2 that effectively coupled G-proteins. Intrathecal PYY3-36 failed to reduce SNI- or incision-induced hypersensitivity in C57BL/6N mice. Incision did not change Npy2r gene expression in dorsal root ganglion.

Conclusions:
We conclude that Y2 at central terminals of primary afferent neurons provide tonic inhibition of mechanical and cold nociception and itch. This switches to the promotion of mechanical and thermal hyperalgesia in models of acute and chronic postsurgical and neuropathic pain, perhaps due to an increase in the population of Y2 that effectively couple to G-proteins. These results support the development of Y2 antagonists for the treatment of chronic postsurgical and neuropathic pain.
Within-hospital Temporal Clustering of Postoperative Complications and Implications for Safety Monitoring and Benchmarking Using ACS-NSQIP Data
Authors: Cohen Mark E. , Liu Yaoming , Ko Clifford Y. , Hall Bruce L. 
Published: August 2024

Objective:
To determine the extent to which within-hospital temporal clustering of postoperative complications is observed in the American College of Surgeons, National Surgical Quality Improvement Program (ACS-NSQIP).

Background:
ACS-NSQIP relies on periodic and on-demand reports for quality benchmarking. However, if rapid increases in postoperative complication rates (clusters) are common, other reporting methods might be valuable additions to the program. This article focuses on estimating the incidence of within-hospital temporal clusters.

Methods:
ACS-NSQIP data from 1,547,440 patients, in 425 hospitals, over a 2-year period was examined. Hospital-specific Cox proportional hazards regression was used to estimate the incidence of mortality, morbidity, and surgical site infection (SSI) over a 30-day postoperative period, with risk adjustment for patient and procedure and with additional adjustments for linear trend, day-of-week, and season. Clusters were identified using scan statistics, and cluster counts were compared, using unpaired and paired t tests, for different levels of adjustment and when randomization of cases across time eliminated all temporal influences.

Results:
Temporal clusters were rarely observed. When clustering was adjusted only for patient and procedure risk, an annual average of 0.31, 0.85, and 0.51 clusters were observed per hospital for mortality, morbidity, and SSI, respectively. The number of clusters dropped after adjustment for linear trend, day-of-week, and season (0.31–0.24; P = 0.012; 0.85–0.80; P = 0.034; and 0.51–0.36; P < 0.001; using paired t tests) for mortality, morbidity, and SSI, respectively. There was 1 significant difference in the number of clusters when comparing data with all adjustments and after data were randomized (0.24 and 0.25 for mortality; P = 0.853; 0.80 and 0.82 for morbidity; P = 0.529; and 0.36 and 0.46 [randomized data had more clusters] for SSI; P = 0.001; using paired t tests) for mortality, morbidity, and SSI, respectively.

Conclusions:
Temporal clusters of postoperative complications were rarely observed in ACS-NSQIP data. The described methodology may be useful in assessing clustering in other surgical arenas.
Heart involvement in systemic sclerosis: emerging concepts
Authors: Fairley Jessica L. , Ross Laura , Nikpour Mandana 
Published: August 2024

Purpose of review
Systemic sclerosis (SSc)-associated heart involvement (SHI) is a significant cause of both morbidity and mortality in individuals with SSc. SHI can take many different forms, and likely is a spectrum of fibroinflammatory cardiac disease. Presenting features include arrhythmia, ventricular systolic or diastolic dysfunction, pericardial disease, and exercise intolerance. Risk of sudden cardiac death in SSc is likely 10–30-fold greater than general population estimates. In this review, we explore what is known about the pathogenesis of SHI, its prevention and management, and discuss available strategies for screening for SHI in light of new recommendations for the routine screening of SHI in all SSc patients.

Recent findings
We describe the spectrum, clinical features, and pathogenesis of SHI. Furthermore, we review the new recommendations for screening for SHI in individuals with SSc.

Summary
There is a large, under-recognized burden of SHI in people living with SSc, which likely contributes to the significant increase in sudden cardiac death observed in SSc. However, a broad-based screening approach, including asymptomatic, low-risk patients should be viewed with caution given the lack of evidence-based treatments and interventions for SHI particularly in this group.