bluuebunny/crossref_metadata_2025_split huggingface dataset:
American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis
Authors: Ward Michael M. , Deodhar Atul , Akl Elie A. , Lui Andrew , Ermann Joerg , Gensler Lianne S. , Smith Judith A. , Borenstein David , Hiratzka Jayme , Weiss Pamela F. , Inman Robert D. , Majithia Vikas , Haroon Nigil , Maksymowych Walter P. , Joyce Janet , Clark Bruce M. , Colbert Robert A. , Figgie Mark P. , Hallegua David S. , Prete Pamela E. , Rosenbaum James T. , Stebulis Judith A. , van den Bosch Filip , Yu David T. Y. , Miller Amy S. , Reveille John D. , Caplan Liron 
Published: September 2015

ObjectiveTo provide evidence‐based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA).MethodsA core group led the development of the recommendations, starting with the treatment questions. A literature review group conducted systematic literature reviews of studies that addressed 57 specific treatment questions, based on searches conducted in OVID Medline (1946–2014), PubMed (1966–2014), and the Cochrane Library. We assessed the quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) method. A separate voting group reviewed the evidence and voted on recommendations for each question using the GRADE framework.ResultsIn patients with active AS, the strong recommendations included use of nonsteroidal antiinflammatory drugs (NSAIDs), use of tumor necrosis factor inhibitors (TNFi) when activity persists despite NSAID treatment, not to use systemic glucocorticoids, use of physical therapy, and use of hip arthroplasty for patients with advanced hip arthritis. Among the conditional recommendations was that no particular TNFi was preferred except in patients with concomitant inflammatory bowel disease or recurrent iritis, in whom TNFi monoclonal antibodies should be used. In patients with active nonradiographic axial SpA despite treatment with NSAIDs, we conditionally recommend treatment with TNFi. Other recommendations for patients with nonradiographic axial SpA were based on indirect evidence and were the same as for patients with AS.ConclusionThese recommendations provide guidance for the management of common clinical questions in AS and nonradiographic axial SpA. Additional research on optimal medication management over time, disease monitoring, and preventive care is needed to help establish best practices in these areas.
Mitochondrial apoptosis and autophagy in the process of adipose‐derived stromal cell differentiation into astrocytes
Authors: Yuan Xiaodong , Zhang Lili , Wang Shujuan , Ou Ya , Wang Quanquan , Peng Wei , Luo Hongjie , Cheng Zanzan , Zhu Xuhong 
Published: September 2015

AbstractThis study aimed to investigate the phenomenon of mitochondrial apoptosis and autophagy in the process of adipose‐derived stromal cell (ADSC) differentiation into astrocytes for 48 h, 7 days, 14 days, and 21 days. Immunocytochemistry and Western blotting indicated that the expression of GFAP reached a peak on the 7th day (P < 0.05). The expression of Bcl‐2 was decreased (P < 0.05), but Bax, Cyt‐c, and LC3 increased with time and reached a maximum on the 14th day (P < 0.05). TEM was used to observe the ultrastructure of mitochondria, apoptosis, and autophagy. An MTT assay indicated that the number of surviving cells decreased. During ADSC differentiation into astrocytes, the effect of Bcl‐2 inhibition on apoptosis decreased, whereas mitochondrial apoptosis and autophagy were enhanced; however, this selective autophagy could not eliminate all the damaged mitochondria, leading to mitochondrial apoptosis.
Appearance of a colovesical fistula at cystoscopy
Authors: Aiken William D. , Reid Gareth , Powell Leo‐Paul 
Published: September 2015

Key Clinical MessageColovesical fistulae typically present with pneumaturia and/or fecaluria. Diverticulitis, inflammatory bowel disease, and malignancies of the colon are the commonest causes. The fistulous tract and adjacent organs are best demonstrated by contrast‐enhanced CT scan with rectal contrast or MRI. Biopsy at cystoscopy/colonoscopy is necessary for complete evaluation and treatment planning.
ChemInform Abstract: Inhibition of Copper Corrosion in Cooling Seawater under Flowing Conditions by Novel Pyrophosphate.
Authors: Deyab M. A. , Essehli R. , El Bali B. 
Published: September 2015

AbstractSrNiP2O7 (SNP) is prepared by solid state reaction of stoichiometric amounts of SrCO3, NiCO3, and (NH4)H2PO4 (1123 K, 10 h) and used in concentrations of 20‐180 mg/L in seawater corrosion tests.
ChemInform Abstract: Diastereoselective Synthesis of cis‐1,2‐Disubstituted Cyclopropanols and Cyclopent‐3‐enols via SmI2 Mediated C—N(Bt) Bond Cleavage.
Authors: Xie Tingting , Zhou Liejin , Shen Mengmeng , Li Jianyong , Lv Xin , Wang Xiaoxia 
Published: September 2015

Abstractin readily available β‐benzotriazolyl ketones
ChemInform Abstract: Copper(I)‐Catalyzed Oxidation of Alkenes Using Molecular Oxygen and Hydroxylamines: Synthesis and Reactivity of α‐Oxygenated Ketones.
Authors: Andia Alexander A. , Miner Matthew R. , Woerpel K. A. 
Published: September 2015

AbstractThe oxidation is general for both styrenes and enynes and involves a radical process in which molecular oxygen is incorporated into the resulting ketone.
ChemInform Abstract: Cp*Co(III)‐Catalyzed Direct Functionalization of Aromatic C—H Bonds with α‐Diazomalonates.
Authors: Liu Xu‐Ge , Zhang Shang‐Shi , Wu Jia‐Qiang , Li Qingjiang , Wang Honggen 
Published: September 2015

AbstractA highly regioselective alkylation of arenes and heteroarenes with α‐diazomalonates is achieved under the assistance of pyrazolyl and pyrimidinyl directing groups.
ChemInform Abstract: Palladium‐Catalyzed Regioselective Decarboxylative Alkylation of Arenes and Heteroarenes with Aliphatic Carboxylic Acids.
Authors: Premi Chanchal , Dixit Ankit , Jain Nidhi 
Published: September 2015

AbstractPyrimidine, pyridine, and azo groups act as directing groups in the regioselective reaction of aromatic substrates with acids (II) to give alkylated indolines, 2‐arylpyridines, and azobenzenes.
ChemInform Abstract: Z‐Selective, anti‐Markovnikov Addition of Alkoxides to Terminal Alkynes: An Electron Transfer Pathway?
Authors: Cuthbertson James , Wilden Jonathan D. 
Published: September 2015

AbstractN,N′‐dimethylethylenediamine enhances the diastereoselective addition of potassium alkoxides to aryl alkynes to yield enol ethers.
ChemInform Abstract: Facile Synthesis of Symmetric Thiosulfonates by Oxidation of Disulfide with Oxone/MX (MX: KBr, KCl, NaBr and NaCl).
Authors: Natarajan Palani 
Published: September 2015

AbstractDisulfides (I) are efficiently oxidized using Oxone/KBr to yield thiosulfonates.
ChemInform Abstract: Preparation and Regioselective Magnesiation or Lithiation of Bis(trimethylsilyl)methyl‐Substituted Heteroaryls for the Generation of Highly Functionalized Heterocycles.
Authors: Klatt Thomas , Werner Veronika , Maximova Marina G. , Didier Dorian , Apeloig Yitzhak , Knochel Paul 
Published: September 2015

AbstractA wide range of bis(trimethylsilyl)methyl (BTSM)‐substituted heteroaryl derivatives is prepared by using Kumada—Corriu or Negishi cross‐coupling reactions.
ChemInform Abstract: Temperature Dependence of Turnover in a Sc(OTf)3‐Catalyzed Intramolecular Schmidt Reaction.
Authors: Fehl Charlie , Hirt Erin E. , Li Sze‐Wan , Aube Jeffrey 
Published: September 2015

AbstractStarting from azide‐tethered ketones the title reaction is applied to the preparation of amides and lactams.
ChemInform Abstract: Palladium‐Catalyzed Domino C—H/N—H Functionalization: An Efficient Approach to Nitrogen‐Bridged Heteroacenes.
Authors: Kamimoto Natsuyo , Schollmeyer Dieter , Mitsudo Koichi , Suga Seiji , Waldvogel Siegfried R. 
Published: September 2015

AbstractThe Pd‐catalyzed reaction of 3‐arylamino‐substituted benzothiophenes with vicinally dibrominated arenes and hetarenes is developed to yield condensed thienoindole type heterocycles (III), (V), and (VII).
ChemInform Abstract: Formal Asymmetric Organocatalytic [3 + 2] Cyclization Between Enecarbamates and 3‐Indolylmethanols: Rapid Access to 3‐Aminocyclopenta[b]indoles.
Authors: Lebee Clement , Kataja Antti O. , Blanchard Florent , Masson Geraldine 
Published: September 2015

AbstractA rapid and highly stereoselective cycloaddition of N‐Cbz‐enecarbamates (I) with substituted 3‐indolylmethanols (II) and (IV) is achieved in the presence of a BINOL derived phosphoric acid as the catalyst.
ChemInform Abstract: Pd‐Catalyzed Cascade Cyclization by Intramolecular Heck Insertion of an Allene—Allylic Amination Sequence: Application to the Synthesis of 3,4‐Fused Tricyclic Indoles.
Authors: Nakano Shun‐ichi , Inoue Naoya , Hamada Yasumasa , Nemoto Tetsuhiro 
Published: September 2015

AbstractA novel protocol for the cascade cyclization of allenes derivatives to form three types of 3,4‐fused tricyclic indoles is reported.
ChemInform Abstract: Alkylation of 5‐(3‐Chlorobenzo[b]thien‐2‐yl)‐1,2,4‐triazole‐3‐thione with Epichlorhydrin and the Role of MW and Solid Support in the Reaction.
Authors: Rezki Nadjet , Aouad Mohamed Reda , Messali Mouslim , El Ashry El Sayed H. 
Published: September 2015

AbstractAn efficient eco‐friendly approach is developed for the selective synthesis of 2,3‐ epoxypropylsulfanyltriazole (IV) by reaction of epoxy‐propane (II) with triazole‐3‐thione (I) under solvent‐free microwave conditions in the presence of a solid support.
ChemInform Abstract: Symmetrical and Non‐symmetrical 2,5‐Diaryl‐1,3,4‐oxadiazoles: Synthesis and Photophysical Properties.
Authors: Paraschivescu Codruta C. , Hadade Niculina D. , Coman Anca G. , Gautier Arnaud , Cisnetti Federico , Matache Mihaela 
Published: September 2015

AbstractDiaryl substituted oxadiazoles are efficiently synthesized from aldehydes and hydrazides via oxidation of the acylhydrazone intermediates (III).
ChemInform Abstract: The First Catalyst and Solvent‐Free Synthesis of 2‐Arylimidazo[2,1‐b][1,3,4]thiadiazoles: A Comparative Assessment of Greenness.
Authors: Wadhwa Preeti , Kaur Tanpreet , Sharma Anuj 
Published: September 2015

AbstractA simple, straightforward and eco‐friendly protocol for the microwave‐assisted one‐pot three‐component Groebke—Blackburn—Bienayme reaction between 5‐aryl‐1,3,4‐thiadiazol‐2‐amines (I), benzaldehydes (II) and isocyanides (III) furnishing the title compounds in excellent yields is established.
ChemInform Abstract: Palladium‐Catalyzed [3 + 3] Annulation Between Diarylamines and α,β‐Unsaturated Acids Through C—H Activation: Direct Access to 4‐Substituted 2‐Quinolinones.
Authors: Kancherla Rajesh , Naveen Togati , Maiti Debabrata 
Published: September 2015

AbstractThe title reaction is readily achieved in the presence of excess TFA to suppress the decarboxylation of α,β‐unsaturated acids.
ChemInform Abstract: Enantioselective Small Molecule Synthesis by Carbon Dioxide Fixation Using a Dual Broensted Acid/Base Organocatalyst.
Authors: Vara Brandon A. , Struble Thomas J. , Wang Weiwei , Dobish Mark C. , Johnston Jeffrey N. 
Published: September 2015

AbstractThis metal‐free method uses inexpensive, nontoxic carbon dioxide as a substrate for the enantioselective synthesis of cyclic carbonates using a dual Broenstedt acid/base organocatalyst.
ChemInform Abstract: Borylation of Primary and Secondary Alkyl Bromides Catalyzed by Cu2O Nanoparticles.
Authors: Zhou Xin‐Feng , Wu Ya‐Dong , Dai Jian‐Jun , Li Yong‐Jia , Huang Yu , Xu Hua‐Jian 
Published: September 2015

AbstractCu2O nanoparticles supported on carbon black are developed as an efficient catalyst for the synthesis of alkylboronic esters (III) and (V) directly from the corresponding alkyl halides.
ChemInform Abstract: Prenylated Diphenyl Ethers from the Mantis‐Associated Fungus Aspergillus versicolor GH‐2
Authors: Hu Sha‐sha , Jiang Nan , Wang Xin‐lei , Chen Chao‐jun , Fan Jing‐yang , Wurin Gege , Ge Hui‐ming , Tan Ren‐xiang , Jiao Rui‐hua 
Published: September 2015

Abstractfive new compounds (I)‐(III) are isolated, together with 11 known ones
Effects of pension fund freezing on firm performance and risk
Authors: Champagne Claudia , Chrétien Stéphane , Coggins Frank 
Published: September 2015

AbstractThis study considers the effect of freezing defined benefit pension funds on shareholder risk and returns. The conditional models used in this study directly assess the effects of a pension fund freeze on returns and on systematic and residual risk. While pension fund freezes do not significantly affect performance or systematic risk, they do significantly reduce short‐term residual risk. Pension fund freezes therefore do not generally present significant financial advantages to shareholders. Only shareholders of firms with pension funds in crisis would benefit from significant systematic risk reductions. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
High CO2/CH4 Selectivity of a Flexible Copper(II) Porous Coordination Polymer under Humid Conditions
Authors: Noro Shin‐ichiro , Matsuda Ryotaro , Hijikata Yuh , Inubushi Yasutaka , Takeda Sadamu , Kitagawa Susumu , Takahashi Yukiko , Yoshitake Masashi , Kubo Kazuya , Nakamura Takayoshi 
Published: September 2015

AbstractInvited for this month's cover is the group of Prof. Shin‐ichiro Noro from Hokkaido University, Japan. The cover picture shows a copper(II) porous coordination polymer that can adsorb CO2 over CH4 at high selectivity under CO2/CH4 mixed gas conditions, even with the coexistence of water. Read the full text of the article at 10.1002/cplu.201500278.
Design methodology for common‐mode stability of OTA‐based gyrators
Authors: Ghamari Saeed , Tasselli Gabriele , Botteron Cyril , Farine Pierre‐André 
Published: September 2015

SummaryThis paper presents a design methodology for common‐mode (CM) stability of operational transconductance amplifier (OTA)‐based gyrators. The topology of gm − C active inductors is briefly reviewed. Subsequently, a comprehensive mathematical analysis on the CM stability of OTA‐based gyrators is presented. Sufficient requirements for the gyrator's CM stability, which easily can be considered during the design process of common‐mode feedback (CMFB) amplifiers, are defined. Based on these stability requirements, a design methodology and a design procedure are proposed. Finally, in order to validate the proposed procedure, a resonator with 20 MHz resonance frequency and a quality factor of 20 is fabricated with UMC 180 nm complementary metal‐oxide‐semiconductor technology, and its CM stability is examined. Copyright © 2015 John Wiley & Sons, Ltd.
Genome‐wide analyses suggest parallel selection for universal traits may eclipse local environmental selection in a highly mobile carnivore
Authors: Stronen Astrid Vik , Jędrzejewska Bogumiła , Pertoldi Cino , Demontis Ditte , Randi Ettore , Niedziałkowska Magdalena , Borowik Tomasz , Sidorovich Vadim E. , Kusak Josip , Kojola Ilpo , Karamanlidis Alexandros A. , Ozolins Janis , Dumenko Vitalii , Czarnomska Sylwia D. 
Published: September 2015

AbstractEcological and environmental heterogeneity can produce genetic differentiation in highly mobile species. Accordingly, local adaptation may be expected across comparatively short distances in the presence of marked environmental gradients. Within the European continent, wolves (Canis lupus) exhibit distinct north–south population differentiation. We investigated more than 67‐K single nucleotide polymorphism (SNP) loci for signatures of local adaptation in 59 unrelated wolves from four previously identified population clusters (northcentral Europe n = 32, Carpathian Mountains n = 7, Dinaric‐Balkan n = 9, Ukrainian Steppe n = 11). Our analyses combined identification of outlier loci with findings from genome‐wide association study of individual genomic profiles and 12 environmental variables. We identified 353 candidate SNP loci. We examined the SNP position and neighboring megabase (1 Mb, one million bases) regions in the dog (C. lupus familiaris) genome for genes potentially under selection, including homologue genes in other vertebrates. These regions included functional genes for, for example, temperature regulation that may indicate local adaptation and genes controlling for functions universally important for wolves, including olfaction, hearing, vision, and cognitive functions. We also observed strong outliers not associated with any of the investigated variables, which could suggest selective pressures associated with other unmeasured environmental variables and/or demographic factors. These patterns are further supported by the examination of spatial distributions of the SNPs associated with universally important traits, which typically show marked differences in allele frequencies among population clusters. Accordingly, parallel selection for features important to all wolves may eclipse local environmental selection and implies long‐term separation among population clusters.
Utilization of proteins from AluProt‐CGNA (a novel protein‐rich lupin variety) in the development of oil‐in‐water multilayer emulsion systems
Authors: Burgos‐Díaz César , Gallardo Miguel , Morales Eduardo , Piornos José A. , Marqués Ana M. , Rubilar Mónica 
Published: September 2015

The formation of multilayered interfaces around oil droplets in oil‐in‐water (O/W) emulsions provides a novel means of improving the quality and stability of many food products. In this work, a system of O/W emulsions containing lipid droplets stabilized by different ionic biopolymers was developed, and their stability under different environmental stresses was evaluated. The protein isolate from a new lupin variety (AluProt‐CGNA) and two polysaccharides—chitosan and xanthan gum—were utilized. AluProt‐CGNA protein‐stabilized emulsions were unstable to aggregation at pH values around their isoelectric point (pI 4.6) and to all the temperatures and salt concentrations evaluated in this study. However, in the presence of chitosan (0.06 wt%), the droplets showed good stability to aggregation from pH 3 to 6, at 30–90°C and at ≤100 mM NaCl. Adding xanthan gum (0.1 wt%) to the system improved emulsion stability from pH 4 to 7, where no phase separation was observed. This study showed that the stability of O/W emulsions containing protein (AluProt‐CGNA)‐coated lipid droplets under environmental stresses can be improved by adding certain concentrations of chitosan and xanthan gum. These findings have important implications for the design of encapsulation and delivery systems for lipophilic compounds in the food industries.Practical applications: The development of multilayer emulsions can be extremely useful to the encapsulation of lipophilic bioactive molecules for food applications, such as polyunsaturated fatty acids (PUFAs), flavors, vitamins, etc. Moreover, this technique provides a system for the creation of O/W emulsions with improved stability to environmental stresses, protection of oil phase, and controlled and triggered release of microencapsulated compounds. In this work, the design of stable O/W emulsions containing PUFAs rich oil droplets surrounded by multiple layer interfacial membranes from food grade ingredients, such as lupin proteins (AluProt‐CGNA), chitosan, and xanthan gum membranes; has been performed. The designed emulsion proved to be stable under different environmental stresses found in many food products. Moreover, thermal stability exhibited by these emulsions could also be an important characteristic for its use in food products.The diagram shows the formation of multilayer emulsions.
CRED: Criteria for reporting and evaluating ecotoxicity data
Authors: Moermond Caroline T.A. , Kase Robert , Korkaric Muris , Ågerstrand Marlene 
Published: September 2015

Abstract

Predicted-no-effect concentrations (PNECs) and environmental quality standards (EQSs) are derived in a large number of legal frameworks worldwide. When deriving these safe concentrations, it is necessary to evaluate the reliability and relevance of ecotoxicity studies. Such evaluation is often subject to expert judgment, which may introduce bias and decrease consistency when risk assessors evaluate the same study. The Criteria for Reporting and Evaluating Ecotoxicity Data (CRED) project attempts to address this problem. It aims to improve the reproducibility, transparency, and consistency of reliability and relevance evaluations of aquatic ecotoxicity studies among regulatory frameworks, countries, institutes, and individual assessors. In the present study, the CRED evaluation method is presented. It includes a set of 20 reliability and 13 relevance criteria, accompanied by extensive guidance. Risk assessors who participated in the CRED ring test evaluated the CRED evaluation method to be more accurate, applicable, consistent, and transparent than the often-used Klimisch method. The CRED evaluation method is accompanied by reporting recommendations for aquatic ecotoxicity studies, with 50 specific criteria divided into 6 categories: general information, test design, test substance, test organism, exposure conditions, and statistical design and biological response. An ecotoxicity study in which all important information is reported is more likely to be considered for regulatory use, and proper reporting may also help in the peer-review process. Environ Toxicol Chem 2016;35:1297–1309. © 2015 The Authors. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. on behalf of SETAC.
Modal decomposition‐based global stability analysis for reduced order modeling of 2D and 3D wake flows
Authors: Stankiewicz Witold , Morzyński Marek , Kotecki Krzysztof , Roszak Robert , Nowak Michał 
Published: September 2015

SummaryThe method for computation of stability modes for two‐ and three‐dimensional flows is presented. The method is based on the dynamic mode decomposition of the data resulting from DNS of the flow in the regime close to stable flow (fixed‐point dynamics, small perturbations about steady flow). The proposed approach is demonstrated on the wake flows past a 2D, circular cylinder, and a sphere. The resulting modes resemble the eigenmodes computed conventionally from global stability analysis and are used in model order reduction of the flow. The designed low‐dimensional Galerkin model uses continuous mode interpolation between dynamic mode decomposition mode bases and reproduces the dynamics of Navier–Stokes equations. Copyright © 2015 John Wiley & Sons, Ltd.
Biphasic responses of human vascular smooth muscle cells to magnesium ion
Authors: Ma Jun , Zhao Nan , Zhu Donghui 
Published: September 2015

AbstractMagnesium‐based alloys are promising in biodegradable cardiovascular stent applications. The degradation products of magnesium stents may have significant impacts on the surrounding vascular cells. However, knowledge on the interactions between magnesium ion and vascular cells at the molecular and cellular levels is still largely missing. Vascular smooth muscle cell (SMC) plays an important role in the pathogenesis of restenosis and wound healing after stent implantation. This study evaluated the short‐term effects of extracellular magnesium ion (Mg2+) on the cellular behaviors of SMCs. Cellular responses to Mg2+were biphasic and in a concentration‐dependent manner. Low concentrations (10 mM) of Mg2+increased cell viability, cell proliferation rate, cell adhesion, cell spreading, cell migration rate, and actin expression. In contrast, higher concentrations (40–60 mM) of Mg2+had deleterious effects on cells. Gene expression analysis revealed that Mg2+altered the expressions of genes mostly related to cell adhesion, cell injury, angiogenesis, inflammation, coagulation, and cell growth. Finding from this study provides some valuable information on SMC responses toward magnesium ions at the cellular and molecular levels, and guidance for future controlled release of magnesium from the stent material. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 347–356, 2016.