bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Effect of Aqueous Polyethylene Glycol on 1,3‐Dipolar Cycloaddition of Benzoylnitromethane/Ethyl 2‐Nitroacetate with Dipolarophiles: Green Synthesis of Isoxazoles and Isoxazolines.
Authors: Gangadhara Chary R. , Rajeshwar Reddy G. , Ganesh Y. S. S. , Vara Prasad K. , Raghunadh Akula , Krishna T. , Mukherjee Soumita , Pal Manojit 
Published: July 2014

AbstractIt is demonstrated that a 1:1 mixture of water and polyethylene glycol 400 promotes the 1,3‐dipolar cycloaddition of carbonyl substituted nitromethanes (I) to terminal alkynes or analogously activated olefins without the need for any catalyst or additive.
ChemInform Abstract: Copper Catalyzed Synthesis of 1‐Aryl‐1,2,3‐triazoles from Aryl Iodides, Alkynes, and Sodium Azide.
Authors: Chen Ying , Zhuo Zi‐Jian , Cui Dong‐Mei , Zhang Chen 
Published: July 2014

AbstractThe catalyst is reused five times with slightly decreasing yields.
ChemInform Abstract: Click Chemistry Inspired Facile Synthesis and Bioevaluation of Novel Triazolyl Analogues of Ludartin.
Authors: Lone Shabir H. , Bhat Khursheed A. , Majeed Rabiya , Hamid Abid , Khuroo Mohd A. 
Published: July 2014

Abstract18 Title compounds of type (III) are prepared and evaluated against 5 human cancer cell lines.
ChemInform Abstract: Fully Regiocontrolled Polyarylation of Pyridine.
Authors: Doebelin Christelle , Wagner Patrick , Bihel Frederic , Humbert Nicolas , Kenfack Cyril Assongo , Mely Yves , Bourguignon Jean‐Jacques , Schmitt Martine 
Published: July 2014

AbstractA new route for the synthesis of the first protypical pentaarylpyridine bearing five different substituents from commercially available starting material (I) is reported.
ChemInform Abstract: A Novel Approach for the Synthesis of Crizotinib Through the Key Chiral Alcohol Intermediate by Asymmetric Hydrogenation Using Highly Active Ir‐Spiro‐PAP Catalyst.
Authors: Qian Jian‐Qiang , Yan Pu‐Cha , Che Da‐Qing , Zhou Qi‐Lin , Li Yuan‐Qiang 
Published: July 2014

AbstractCrizotinib is a tyrosin kinase inhibitor and used against bronchial carcinoma.
ChemInform Abstract: Reactivity of Pyridines Bearing EWG with Bis‐(TMS)ketene Acetals. Substituent‐Induced Lactonization Reaction.
Authors: Rivera‐Hernandez Alejandro , Chans Guillermo M. , Rudler Henri , Lopez Cortes Jose G. , Toscano R. Alfredo , Alvarez‐Toledano Cecilio 
Published: July 2014

AbstractSeveral new dihydropyridine carboxylic acids are prepared.
ChemInform Abstract: Synthesis and Antibacterial Activity of Ethyl 2‐Amino‐6‐methyl‐5‐oxo‐4‐aryl‐5,6‐dihydro‐4H‐pyrano [3,2‐c]quinoline‐3‐carboxylate.
Authors: Asghari Sakineh , Ramezani Samaneh , Mohseni Mojtaba 
Published: July 2014

AbstractAn efficient route for the synthesis of the title compounds (IV), which show moderate to good bacteriostatic effects, is given.
ChemInform Abstract: Highly Efficient Four‐Component Synthesis of 4(3H)‐Quinazolinones: Palladium‐Catalyzed Carbonylative Coupling Reactions.
Authors: He Lin , Li Haoquan , Neumann Helfried , Beller Matthias , Wu Xiao‐Feng 
Published: July 2014

AbstractA novel Pd‐catalyzed four‐component carbonylative‐coupling for the construction of N‐substituted 4(3H)‐quinazolinones in a one‐pot manner is presented.
ChemInform Abstract: Synthesis of Novel 5‐Oxaprotoberberines as Bioisosteres of Protoberberines.
Authors: Jin Yifeng , Khadka Daulat Bikram , Yang Su Hui , Zhao Chao , Cho Won‐Jea 
Published: July 2014

AbstractThe synthesis of 5‐oxaprotoberberines involves the coupling of toluamides (I) with 2‐cyanophenol derivatives and SN2 reaction with diiodomethane to form the methylene bridge between amide and hydroxyl group.
ChemInform Abstract: Facile Access to a Benzoazepinoquinazolinone via a Free Radical Cyclization.
Authors: Shawakfeh Khaled Q. , Ishtaiwi Zakariyya N. , Al‐Said Naim H. 
Published: July 2014

AbstractSubstrate (I) undergoes a free‐radical cascade reaction via 6‐exo‐trig and 7‐endo‐trig cyclization process to form the new compound (II), a potential precursor for the synthesis of the cyclopropanequinone structure found in duocarmycins.
ChemInform Abstract: Ligand Bite Angle‐Dependent Palladium‐Catalyzed Cyclization of Propargylic Carbonates to 2‐Alkynyl Azacycles or Cyclic Dienamides.
Authors: Daniels David S. B. , Jones Alison S. , Thompson Amber L. , Paton Robert S. , Anderson Edward A. 
Published: July 2014

AbstractThe cyclization products are obtained as inseparable mixtures.
ChemInform Abstract: Stereoselective Synthesis of Medium‐Sized Cyclic Ethers: Application of C‐Glycosylation Chemistry to Seven‐ to Nine‐Membered Lactone‐Derived Thioacetals and Their Sulfone Counterparts.
Authors: Suga Yuto , Fuwa Haruhiko , Sasaki Makoto 
Published: July 2014

AbstractA number of α‐substituted medium sized cyclic ethers are prepared in an efficient and stereoselective manner.
ChemInform Abstract: Total Synthesis of (‐)‐Englerin A.
Authors: Zhang Jinghua , Zheng Shuyan , Peng Wei , Shen Zhengwu 
Published: July 2014

AbstractThis new and novel total synthesis gives englerin A in 11% overall yield and includes an intramolecular olefin metathesis ring closure reaction and a highly stereoselective oxygen bridge formation as key steps.
ChemInform Abstract: Two Lignans, One Alkaloid, and Flavanone from the Twigs of Feroniella lucida.
Authors: Sriyatep Teerayut , Chakthong Suda , Leejae Sukanlaya , Voravuthikunchai Supayang P. 
Published: July 2014

AbstractLucidenal (I), lucidanin (II), alkaloid (III), and flavanone (IV) are isolated from the title twigs.
ChemInform Abstract: The Ternary Amide KLi3(NH2)4: An Important Intermediate in the Potassium Compound‐Added Li—N—H Systems.
Authors: Dong Bao‐Xia , Song Liang , Ge Jun , Teng Yun‐Lei , Zhang Shi‐Yang 
Published: July 2014

AbstractIn the study of the KH‐added H2 storage system LiH‐NH3 (KH‐added LiH‐LiNH2, KH‐added LiNH2, and KNH2‐added LiNH2), KLi3(NH2)4 is found to be an important intermediate formed in dehydrogenation and hydrogenation of the KH‐added Li‐N‐H system.
ChemInform Abstract: One‐Dimensional Nanostructure Based Materials for Versatile Photocatalytic Applications
Authors: Weng Bo , Liu Siqi , Tang Zi‐Rong , Xu Yi‐Jun 
Published: July 2014

AbstractReview: [applications of 1D‐based nanostructures in photocatalysis, including nonselective processes for the degradation of pollutants, solar energy conversion to fuels and selective transformations for organic synthesis; 308 refs.
DNA Nanostructure‐Based Imaging Probes and Drug Carriers
Authors: Zhan Pengfei , Jiang Qiao , Wang Zhen‐gang , Li Na , Yu Haiyin , Ding Baoquan 
Published: July 2014

AbstractSelf‐assembled DNA nanostructures are well‐defined nanoscale shapes, with uniform sizes, precise spatial addressability, and excellent biocompatibility. With these features, DNA nanostructures show great potential for biomedical applications; various DNA‐based biomedical imaging probes or payload delivery carriers have been developed. In this review, we summarize the recent developments of DNA‐based nanostructures as tools for diagnosis and cancer therapy. The biological effects that are brought about by DNA nanostructures are highlighted by in vitro and in vivo imaging, antitumor drug delivery, and immunostimulatory therapy. The challenges and perspectives of DNA nanostructures in the field of nanomedicine are discussed.
Importance of the 6′‐Hydroxy Group and Its Configuration for Apramycin Activity
Authors: Mandhapati Appi Reddy , Shcherbakov Dimitri , Duscha Stefan , Vasella Andrea , Böttger Erik C. , Crich David 
Published: July 2014

AbstractA series of apramycin derivatives was prepared and investigated for antibacterial activity and the ability to inhibit protein synthesis in cell‐free translation assays. The effect of various modifications at the 6′‐ and N7′‐positions on antiribosomal activity is discussed in terms of their influence on drug binding to specific residues in the decoding A‐site. These studies contribute to the development of a structure–activity relationship for the antibacterial activity of the apramycin class of aminoglycosides and to the future design and development of more active and less toxic antibiotics.
Computational Reference Data for the Photochemistry of Cyclobutane Pyrimidine Dimers
Authors: Barbatti Mario 
Published: July 2014

AbstractThe cis–syn cyclobutane pyrimidine dimer is one of the major classes of carcinogenic UV‐induced DNA photoproducts. In this work, diverse high‐level quantum‐chemical methods were used to determine the spectroscopic properties of neutral (singlet and triplet) and charged (cation and anion) species of thymine dimers. Maps of potential energy, charge distribution, electron affinity, and ionization potential of the thymidine dimers were computed along the two dimerization coordinates for neutral and charged species, as well as for the singlet excited state. This set of data aims at providing consistent results computed with the same methods as for photodamage and repair. Based on these results, several different photo‐, heat‐, and charge‐induced mechanisms of dimerization and repair are characterized and discussed. Additionally, a new stable dimer with methylmethylidene‐hexahydropyrimidine structure was found in the S0 state.
ROFRET: A Molecular‐Scale Fluorescent Probe Displaying Viscosity‐Enhanced Intramolecular Förster Energy Transfer
Authors: Bai Dan , Benniston Andrew C. , Whittle Victoria L. , Lemmetyinen Helge , Tkachenko Nikolai V. 
Published: July 2014

AbstractThe fluorescent probe ROFRET contains a Bodipy molecular rotor connected through a short triazole‐based spacer to a fully alkylated Bodipy. Förster resonance energy transfer takes place from the rotor to the other Bodipy, and is enhanced to a limiting value as the viscosity of the solvent increases. Time‐resolved spectroscopy and steady‐state studies are consistent with both forward and reverse energy transfer, and delayed fluorescence.
Gas‐Phase Interactions between Lead(II) Ions and Cytosine: Tandem Mass Spectrometry and Infrared Multiple‐Photon Dissociation Spectroscopy Study
Authors: Salpin Jean‐Yves , Haldys Violette , Guillaumont Sébastien , Tortajada Jeanine , Hurtado Marcela , Lamsabhi Al Mokhtar 
Published: July 2014

AbstractGas‐phase interactions between Pb2+ions and cytosine (C) were studied by combining tandem mass spectrometry, infrared multiple photon dissociation spectroscopy, and density functional theory (DFT) calculations. Both singly and doubly charged complexes were generated by electrospray. The [Pb(C)−H]+complex was extensively studied, and this study shows that two structures, involving the interaction of the metal with the deprotonated canonical keto‐amino tautomer of cytosine, are generated in the gas phase; the prominent structure is the bidentate form involving both the N1 and O2 electronegative centers. The DFT study also points out a significant charge transfer from the nucleobase to the low‐lying p orbitals of the metal and a strong polarization of the base upon complexation. The various potential energy surfaces explored to account for the fragmentation observed are consistent with the high abundance of the [PbNH2]+fragment ion.
Keeping Nanoparticles Fully Functional: Long‐Term Storage and Alteration of Magnetite
Authors: Widdrat Marc , Kumari Monika , Tompa Éva , Pósfai Mihály , Hirt Ann M. , Faivre Damien 
Published: July 2014

AbstractMagnetite is an iron oxide found in rocks. Its magnetic properties are used for paleoclimatic reconstructions. It can also be synthesized in the laboratory to exploit its magnetic properties for bio‐ and nanotechnological applications. However, although the magnetic properties depend on particle size in a well‐understood manner, they also depend on the structure of the oxide, because magnetite oxidizes to maghemite under environmental conditions. The dynamics of this process have not been well described. Here, a study of the alteration of magnetite particles of different sizes as a function of their storage conditions is presented. Smaller nanoparticles are shown to oxidize more rapidly than larger ones, and that the lower the storage temperature, the lower the measured oxidation. In addition, the magnetic properties of the altered particles are not decreased dramatically, thus suggesting that this alteration will not impact the use of such nanoparticles as medical carriers.
Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4+ T‐lymphocyte subset in normal and mycosis fungoides skin
Authors: Sako Nouhoum , Schiavon Valérie , Bounfour Touda , Dessirier Valérie , Ortonne Nicolas , Olive Daniel , Ram‐Wolff Caroline , Michel Laurence , Sicard Hélène , Marie‐Cardine Anne , Bagot Martine , Bensussan Armand , Schmitt Christian 
Published: July 2014

AbstractCD160 is a GPI‐anchored Ig‐like receptor identified by the BY55 mAb on human circulating CD56dim+ NK cells and TCRγδ lymphocytes. In addition, while most intestinal T lymphocytes express it, only a minor circulating CD4+ or CD8+ T lymphocyte subset is CD160+. Here we describe a population of CD4+CD160+ human blood T lymphocytes of circulating cutaneous T cells. These rare T lymphocytes represent 2.1 ± 1.9% of the circulating CD3+CD4+ T cells, coexpress CD8αα, CD244, and perforin but lack CD28 expression, a phenotype corresponding to effector memory cytotoxic T‐lymphocytes. Functional studies further confirmed their cytotoxic potential. These cells lack αEβ7 integrin and CCR7 expression but do express skin‐addressing molecules CLA, and CCR4. In normal human skin, CD4+CD160+ cells represent 34.6 ± 14.7% of the CD4+ T lymphocytes extracted by collagenase treatment. These T cells coexpress CLA (81 ± 13.6%), CCR4 (62.3 ± 15.9%), and some CD8αα (19.6 ± 13%) or CCR7 (24.4 ± 11.7%) expression. Cutaneous T‐cell lymphoma cells express the natural killer receptor KIR3DL2 (CD158k) used as a tumor marker. Not only we confirmed the expression of this marker in the blood and/or skin of mycosis fungoides patients but we also show for the first time CD158k expression (often associated with CD160) on cutaneous CD4+ T cells from healthy individuals (25.3 ± 15%). Therefore, CD4+CD160+ T cells expressing CD158k might represent specialized cutaneous lymphocytes devoted to immune surveillance, from which could originate cutaneous T‐cell lymphomas such as mycosis fungoides. © 2014 International Society for Advancement of Cytometry
Polynuclear Heterometallic Complexes from Metal Powders: The “Direct Synthesis” Approach
Authors: Nesterov Dmytro S. , Nesterova Oksana V. , Kokozay Vladimir N. , Pombeiro Armando J. L. 
Published: July 2014

AbstractThe synthesis of polynuclear coordination compounds, particularly heterometallic coordination compounds, remains a challenge for modern chemistry. Spontaneous self‐assembly (SSA) is a primary approach that proceeds by broad screening, typically with simple, flexible ligands and available metal salts. The “direct synthesis” is a class of SSA, but prescribes the use of zero‐valent metal(s) as a starting material, typically oxidized by air oxygen, which results in a deficiency of anions in the reaction mixture and forces deprotonation of the protic ligand(s) with the formation of unexpected products. The “direct synthesis” approach has been successfully applied to the preparation of heterometallic complexes, which has allowed the isolation of numerous complexes, many with uncommon structures. In this review we summarize our experience in the field of the “direct synthesis” of polynuclear heterometallic complexes, covering preparative and structural aspects as well as applications of the compounds obtained.
Synthesis of 1,4‐Dihydropyridines and Their Fluorescence Properties
Authors: Sueki Shunsuke , Takei Ryo , Zaitsu Yuto , Abe Junya , Fukuda Akane , Seto Keisuke , Furukawa Yukio , Shimizu Isao 
Published: July 2014

AbstractWe have successfully synthesized 3,4,5‐substituted 1,4‐dihydropyridines (1,4‐DHPs) from amine hydrochloride salts, aldehydes, and acetals in good yields without the addition of a catalyst. The synthesized 1,4‐DHPs exhibit various wavelengths of fluorescence, which could be tuned by changing the substituents at the 3‐ and 5‐positions of the 1,4‐DHPs.
Fluoro‐Ene Reaction Versus [2+2] Cycloaddition in the Thermal C2–C6 Cyclization of Enyne‐Allenes: An Experimental and Theoretical Investigation
Authors: Cinar M. Emin , Vavilala Chandrasekhar , Jaquet Ralph , Bats Jan W. , Schmittel Michael 
Published: July 2014

AbstractA series of fluoroalkyl‐substituted enyne‐allenes have been synthesized by a new route with the aim of elucidating the possibility of a fluoro‐ene reaction via an intermediate fulvenyl diradical generated in the thermal C2–C6 (Schmittel) cyclization reaction. As a result of the strong C–F bond, fluorine atom transfer was not observed. Instead, 1H‐cyclobuta[a]indenes were formed in good yields despite the high strain energy. DFT calculations at the B3LYP level of theory indicated that although the fluoro‐ene reaction is the most exothermic reaction available, cyclobutene formation is kinetically favored over the [1,5]‐fluorine shift by 5–15 kcal mol–1 in various model compounds.
Simultaneous Determination of Iron and Copper in Ethanol Fuel Using Nafion/Carbon Nanotubes Electrode
Authors: Silva Josiel J. , Paim Leonardo L. , Stradiotto Nelson R. 
Published: July 2014

AbstractThis work presents the analytical method development for iron and copper determination in ethanol fuel. This method was developed using stripping voltammetry with a glassy carbon electrode modified with Nafion/Carbon‐nanotubes. With linear sweep stripping voltammetry was achieved a limit of detection of 7.1×10−7 mol L−1 for Fe3+ and 5.1×10−8 mol L−1 for Cu2+. The amperometric sensitivities were 2.0×106 µA mol−1 L for Fe3+ and 2.8×107 µA mol−1 L for Cu2+. The recovery study showed that the method has good accuracy and repeatability, with recovery of 108 and 103 % for Fe3+ and Cu2+ respectively.
Zwitterionic Phosphirenium Borates Derived from Bis(alkynyl)mesityl Phosphanes and Tris(pentafluorophenyl)borane
Authors: Möbus Juri , Malessa Kira , Frisch Hendrik , Daniliuc Constantin G. , Fröhlich Roland , Kehr Gerald , Erker Gerhard 
Published: July 2014

ABSTRACTFrom a series of bis(alkynyl)mesityl phosphanes 5, we prepared phosphirenium borate compounds 6 in high yields by reaction with B(C6F5)3 at room temperature. The zwitterionic compounds 6 are conveniently accessible and can be obtained with unique substitution patterns by this route. For two examples, we show the conversion of 6 to the respective 3‐borylated phosphole derivatives 7 through multiple 1,1‐carboboration reactions. In a useful one‐pot methodology, the phosphirenium borates 6 are converted to air‐stable 3‐arylated phospholes 8 by a sequential 1,1‐carboboration/ Suzuki–Miyaura type cross‐coupling reaction.
Tobacco Control Policies and Sudden Infant Death Syndrome in Developed Nations
Authors: King Christian , Markowitz Sara , Ross Hana 
Published: July 2014

AbstractThis paper estimates the effects of higher cigarette prices and smoke‐free policies on the prevalence of Sudden Infant Death Syndrome (SIDS). Using a panel of developed countries over a 20 year period, we find that higher cigarette prices are associated with reductions in the prevalence of SIDS. However, we find no evidence that smoke‐free policies are associated with declines in SIDS.
Objects and landmarks: Hippocampal place cells respond differently to manipulations of visual cues depending on size, perspective, and experience
Authors: Scaplen Kristin M. , Gulati Arune A. , Heimer‐McGinn Victoria L. , Burwell Rebecca D. 
Published: July 2014

ABSTRACTHuman navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influenced by local cues. One difficulty in examining mechanisms by which distal and local cues influence the activity of hippocampal cells is that distant cues are necessarily processed visually, whereas local cues are generally multimodal. Here, we compared the effects of 90° rotations under different cue conditions in which cues were restricted to the visual modality. Three two‐dimensional visual cue conditions were presented in a square open field: a large vertical cue on one wall, a large floor cue in a corner abutting two walls, and a smaller complex floor cue in a corner adjacent to two walls. We show that rotations of large distal cues, whether on the wall or floor, were equally effective in controlling place fields. Rotations of the smaller floor cues were significantly more likely to result in remapping, whether or not animals were also exposed to the distal polarizing cues. Responses of distal and local cues were affected differently by extended experience. Our data provide evidence that hippocampal place cell responses to visual cues are influenced by perspective, salience of the cue, and prior experience. The hippocampus processes visual cues either as stable landmarks useful for orientation and navigation or as nonstationary objects or features of the local environment available for associative learning or binding items in context. © 2014 Wiley Periodicals, Inc.
The effect of low‐permeability fault zones on groundwater flow in a compartmentalized system. Experimental evidence from a carbonate aquifer (Southern Italy)
Authors: Petrella Emma , Aquino Durante , Fiorillo Francesco , Celico Fulvio 
Published: July 2014

AbstractThe hydrogeological behaviour of fault zones in carbonate aquifers is often neglected in conceptual and numerical models. Furthermore, no information is available regarding the relationships between piezometric levels when significant compartmentalization occurs due to the occurrence of low‐flow fault zones. The aim of this study was to refine the conceptualization of subsurface flow in faulted carbonate aquifers and to analyse relationships between sub‐basins within a compartmentalized aquifer system in Southern Italy. The interactions between compartments that straddle low‐flow faults were investigated over four hydrologic years using a statistical approach to compare (i) the hydraulic heads within two wells located up‐ and down‐gradient of tectonic discontinuities as well as (ii) the rainfall and piezometric levels.The results of this study suggest that a set of barriers exists between the wells, and, therefore, the total head loss observed between the wells (approximately 80 m) should be distributed across several aquitards, with one aquitard exhibiting a relatively high permeability or low degree of integrity. Due to slight differences in permeability, transient conditions in aquitards can occur over relatively short periods, which is in agreement with the results of the statistical data analysis. Consequently, rather than being caused by pure aquitards, aquifer system compartmentalization likely results from slight differences in the permeability between lower‐permeability fault zones and adjacent higher‐permeability protoliths. Copyright © 2014 John Wiley & Sons, Ltd.