bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation and Reproducibility of a Biplanar Imaging System Versus Conventional Radiography of Foot and Ankle Radiographic Parameters
Authors: Rungprai Chamnanni , Goetz Jessica E. , Arunakul Marut , Gao Yubo , Femino John E. , Amendola Annunziato , Phisitkul Phinit 
Published: August 2014

Background: Diagnosis of foot deformities is frequently supported by objective measures of bony alignment made on AP and lateral weight-bearing radiographs. The EOS biplanar imaging system has the capability of simultaneously capturing orthogonal AP and lateral images of the foot during weight-bearing with reduced radiation exposure. The purpose of this study was to evaluate the validity and reproducibility of common foot and ankle radiographic measurements made on images acquired with the EOS biplanar imaging system. Methods: Fifty consecutive patients indicated for foot and ankle realignment surgeries were enrolled. Radiographic studies included conventional AP and lateral ankle weight-bearing radiographs and long-leg AP and lateral weight-bearing images acquired using the EOS system with both a staggered feet and a nonstaggered feet position. Sixteen radiographic parameters of foot, ankle, and lower limb alignment were measured by 2 blinded observers, with 1 observer repeating all measurements 6 weeks later. Inter- and intraobserver reliability was assessed using intraclass correlation coefficients. Between-group comparison was assessed using Pearson correlation coefficients, ANOVA, and paired t-tests. Results: There was no statistically significant difference in any commonly used foot and ankle radiographic parameters measured on conventional radiographs or EOS images acquired with staggered and nonstaggered feet (ANOVA P = .792 to .997 and paired t tests P = .067 to .977). However, the staggered foot position resulted in significantly different limb length measurements in the rear leg ( P = .000 to .049). Intra- and interrater reliabilities of limb alignment measurements from EOS system images were excellent in both foot positions (ICC = .938 to 1.000). Conclusion: Images acquired using EOS biplanar imaging system allowed for valid and reliable measurement of commonly used foot and ankle radiographic parameters; however, the staggered foot position required for simultaneous imaging of both feet in the lateral view affected limb length measurements in the rear leg. Level of Evidence: Level II, prospective comparative study.
Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients
Authors: Darcy Christabelle J , Minigo Gabriela , Piera Kim A , Davis Joshua S , McNeil Yvette R , Chen Youwei , Volkheimer Alicia D , Weinberg J Brice , Anstey Nicholas M , Woodberry Tonia 
Published: August 2014

Abstract
Introduction
Impaired T cell function in sepsis is associated with poor outcome, but the mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells (MDSCs) deplete arginine, impair T cell receptor CD3 zeta-chain expression and T cell function and are linked to poor clinical outcome, but their role during acute human infectious disease and in particular sepsis remains unknown. Hypoarginemia is prevalent in sepsis. This study aimed to determine whether neutrophils that co-purify with PBMC express arginase, and if arginine depletion constrains T cell CD3 zeta-chain expression and function in human sepsis.

Methods
Using flow cytometry, cell culture, HPLC, arginase activity and mRNA detection, our study examined whether neutrophils, with reduced buoyant density isolated in the Ficoll interface, metabolise L-arginine and suppress T cell proliferation in sepsis. A total of 35 sepsis patients (23 with septic shock) and 12 hospital controls in a tertiary referral hospital in tropical Australia were evaluated.

Results
Only sepsis patients had interphase neutrophils, neutrophils co-purifying with mononuclear cells (≤1.077 specific gravity). The percentage of interphase neutrophils in sepsis was proportional to sepsis severity and correlated with plasma IL-6 concentrations. Ex vivo, sepsis-derived interphase neutrophils expressed arginase, metabolised culture L-arginine and suppressed T cell proliferation and CD3 zeta-chain expression. In vivo, in septic shock there was a longitudinal inverse association between interphase neutrophil number and CD3 zeta-chain expression. Depletion or inhibition of interphase neutrophils in vitro restored zeta-chain expression and T cell function.

Conclusions
For the first time during an acute human infection, interphase neutrophils that express arginase were found to circulate in sepsis, in proportion to disease severity. These neutrophil-MDSCs impair T cell CD3 zeta-chain expression and T cell function via L-arginine metabolism, and likely contribute to the T cell dysfunction seen in sepsis. Modulation of neutrophil-MDSC or their downstream effects warrant consideration as targets for novel adjunctive therapies in sepsis.
Mid-to long-term results of revision total hip replacement in patients aged 50 years or younger
Authors: Lee P. T. H. , Lakstein D. L. , Lozano B. , Safir O. , Backstein J. , Gross A. E. 
Published: August 2014

Revision total hip replacement (THR) for young patients is challenging because of technical complexity and the potential need for subsequent further revisions. We have assessed the survivorship, functional outcome and complications of this procedure in patients aged < 50 years through a large longitudinal series with consistent treatment algorithms. Of 132 consecutive patients (181 hips) who underwent revision THR, 102 patients (151 hips) with a mean age of 43 years (22 to 50) were reviewed at a mean follow-up of 11 years (2 to 26) post-operatively. We attempted to restore bone stock with allograft where indicated. Using further revision for any reason as an end point, the survival of the acetabular component was 71% (sd 4) and 54% (sd 7) at ten- and 20 years. The survival of the femoral component was 80% (sd 4) and 62% (sd 6) at ten- and 20 years. Complications included 11 dislocations (6.1%), ten periprosthetic fractures (5.5%), two deep infections (1.1%), four sciatic nerve palsies (2.2%; three resolved without intervention, one improved after exploration and freeing from adhesions) and one vascular injury (0.6%). The mean modified Harris Hip Score was 41 (10 to 82) pre-operatively, 77 (39 to 93) one year post-operatively and 77 (38 to 93) at the latest review.This overall perspective on the mid- to long-term results is valuable when advising young patients on the prospects of revision surgery at the time of primary replacement.Cite this article: Bone Joint J 2014;96-B:1047–51.
A retrospective analysis of the use of cannulated compression screws and a vascularised iliac bone graft in the treatment of displaced fracture of the femoral neck in patients aged < 50 years
Authors: Dewei Z. , Xiaobing Y. 
Published: August 2014

There is a high risk of the development of avascular necrosis of the femoral head and nonunion after the treatment of displaced subcapital fractures of the femoral neck in patients aged < 50 years. We retrospectively analysed the results following fixation with two cannulated compression screws and a vascularised iliac bone graft. We treated 18 women and 16 men with a mean age of 38.5 years (20 to 50) whose treatment included the use of an iliac bone graft based on the ascending branch of lateral femoral circumflex artery. There were 20 Garden grade III and 14 grade IV fractures. Clinical and radiological outcomes were evaluated. The mean follow-up was 5.4 years (2 to 10). In 30 hips (88%) union was achieved at a mean of 4.4 months (4 to 6). Nonunion occurred in four hips (12%) and these patients had a mean age of 46.5 years (42 to 50) and underwent revision to a hip replacement six months after operation. The time to union was dependent on age with younger patients achieving earlier union (p < 0.001). According to the Harris hip score which was available for 27 of the 30 hips with satisfactory union, excellent results were obtained in 15 (score ≥ 90 points), fair in ten (score 80 to 90 points), and poor in two hips (≤ 80 points). One patient aged 48 years developed avascular necrosis of femoral head six years after operation and underwent total hip replacement.The management of displaced subcapital fractures of the femoral neck, in patients aged < 50 years, with two cannulated compression screws and an iliac bone graft based on the ascending branch of lateral femoral circumflex artery, gives satisfactory results with a low rate of complication including avascular necrosis and nonunion.Cite this article: Bone Joint J 2014;96-B:1024–8.
The influence of the choice of closing wedge angle on leg length discrepancy after proximal femoral varus osteotomy
Authors: Segaren N. , Abdul-Jabar H. B. , Hashemi-Nejad A. 
Published: August 2014

Proximal femoral varus osteotomy improves the biomechanics of the hip and can stimulate normal acetabular development in a dysplastic hip. Medial closing wedge osteotomy remains the most popular technique, but is associated with shortening of the ipsilateral femur. We produced a trigonometric formula which may be used pre-operatively to predict the resultant leg length discrepancy (LLD). We retrospectively examined the influence of the choice of angle in a closing wedge femoral osteotomy on LLD in 120 patients (135 osteotomies, 53% male, mean age six years, (3 to 21), 96% caucasian) over a 15-year period (1998 to 2013). A total of 16 of these patients were excluded due to under or over varus correction. The patients were divided into three age groups: paediatric (< 10 years), adolescent (10 to 16 years) and adult (> 16 years). When using the same saw blades as in this series, the results indicated that for each 10° of angle of resection the resultant LLD equates approximately to multiples of 4 mm, 8 mm and 12 mm in the three age groups, respectively. Statistical testing of the 59 patients who had a complete set of pre- and post-operative standing long leg radiographs, revealed a Pearson’s correlation coefficient for predicted versus radiologically observed shortening when using a wedge of either 10° or 20° of 0.93 (p < 0.001). The 95% limits of agreement from the Bland–Altman analysis for this subgroup were –3.5 mm to +3.3 mm. It has been accepted that a 10 mm discrepancy is clinically acceptable. This study identified a geometric model that provided satisfactory accuracy when using specific saw blades of known thicknesses for this formula to be used in clinical practice. Cite this article: Bone Joint J 2014;96-B:1124–9
A prejudiced view
Authors: Monsell F. P. 
Published: August 2014

The contemporary practice of orthopaedic surgery requires an evidence-based approach to support all medical and surgical interventions. In this essay, the author expresses a forthright, personal and somewhat prejudiced appeal to retain the legitimacy of clinical decision making in conditions that are rare, contain multiple variables, have a solution that generally works or has an unpredictable course. Cite this article: Bone Joint J 2014;96-B:1002–4.
A modified Imhäuser osteotomy
Authors: Bali N. S. , Harrison J. O. , Bache C. E. 
Published: August 2014

The aim of this study was to determine whether an osteoplasty of the femoral neck performed at the same time as an intertrochanteric Imhäuser osteotomy led to an improved functional outcome or increased morbidity. A total of 20 hips in 19 patients (12 left, 8 right, 13 male, 6 female), who underwent an Imhäuser intertrochanteric osteotomy following a slipped capital femoral epiphysis were assessed over an eight-year period. A total of 13 hips in 13 patients had an osteoplasty of the femoral neck at the same time. The remaining six patients (seven hips) had intertrochanteric osteotomy alone. The mean age was 15.3 years (13 to 20) with a mean follow-up of 57.8 months (15 to 117); 19 of the slips were severe (Southwick grade III) and one was moderate (grade II), with a mean slip angle of 65.3° (50° to 80°); 17 of the slips were stable and three unstable at initial presentation. The mean Non-Arthritic Hip Scores (NAHS) in patients who underwent osteoplasty was 91.7 (76.3 to 100) and the mean NAHS in patients who did not undergo osteoplasty was 76.6 (41.3 to 100) (p = 0.056). Two patients required a subsequent arthroplasty and neither of these patients had an osteoplasty. No hips developed osteonecrosis or chondrolysis, and there was no increase in complications related to the osteoplasty. We recommend that for patients with a slipped upper femoral epiphysis undergoing an intertrochanteric osteotomy, the addition of an osteoplasty of the femoral neck should be considered.Cite this article: Bone Joint J 2014;96-B:1119–23.
New Connectors Coming for Enteral Feeding Tubes; Marqibo and Risk of Errors; Angeliq is Not a Birth Control Pill
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: August 2014

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Galactokinase Is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila
Authors: Lee Teresa E , Yu Lin , Wolf Matthew J , Rockman Howard A 
Published: August 2014

Abstract
Activated/uninhibited calcineurin is both necessary and sufficient to induce cardiac hypertrophy, a condition that often leads to dilated cardiomyopathy, heart failure, and sudden cardiac death. We expressed constitutively active calcineurin in the adult heart of Drosophila melanogaster and identified enlarged cardiac chamber dimensions and reduced cardiac contractility. In addition, expressing constitutively active calcineurin in the fly heart using the Gal4/UAS system induced an increase in heart wall thickness. We performed a targeted genetic screen for modifiers of calcineurin-induced cardiac enlargement based on previous calcineurin studies in the fly and identified galactokinase as a novel modifier of calcineurin-induced cardiomyopathy. Genomic deficiencies spanning the galactokinase locus, transposable elements that disrupt galactokinase, and cardiac-specific RNAi knockdown of galactokinase suppressed constitutively active calcineurin-induced cardiomyopathy. In addition, in flies expressing constitutively active calcineurin using the Gal4/UAS system, a transposable element in galactokinase suppressed the increase in heart wall thickness. Finally, genetic disruption of galactokinase suppressed calcineurin-induced wing vein abnormalities. Collectively, we generated a model for discovering novel modifiers of calcineurin-induced cardiac enlargement in the fly and identified galactokinase as a previously unknown regulator of calcineurin-induced cardiomyopathy in adult Drosophila.
Accurate Measurements of Liquid-Condensate Rate With Multiphase-Metering Technology Improve Ecological Impact of Well Test in Deepwater Well Offshore Brazil
Authors: Maizeret Pierre-David , Reid David , Theuveny Bertrand 
Published: August 2014

Summary
Separators have a proven track record and are widely used in well-testing operations. However, their range of applications is relatively narrow, and they can encounter limitations with fluids for which separation quality is an issue.
This paper describes a well test in a deepwater well offshore Brazil. To be able to accommodate different production scenarios, two separators and a multiphase meter were used to measure the flow rates. During the test, a comparison of the flow rates from the multiphase flowmeter and those reported by the separator made possible the identification of some carry-over in the separator at a high choke setting. When the choke size was increased, the separator gas rate increased, whereas the liquid rate dropped at the separator, resulting in a very low condensate/gas ratio (CGR). The multiphase meter, on the other hand, reported a constant CGR, allowing for the real-time diagnostic that carry-over was occurring at the separator. At the end of the test, the same increased choke setting was used for a short period of time to confirm the behavior. The same rate results were observed for each phase, and a small amount of liquid could be seen in the gas flare. The final proof came from the analysis of the downhole samples, which confirmed the CGR measured with the multiphase meter.
The consistent results from the multiphase meter make the meter ideal to validate the flow-rate measurements from the reservoir and to improve the burning efficiency. By allowing early identification of imperfect separation, the multiphase meter reduces the health, safety, and environmental (HSE) risks associated with well-test operations.
Well Recovery, Drainage Area, and Future Drill-Well Inventory: Empirical Study of the Barnett Shale Gas Play
Authors: Ikonnikova S.. , Browning J.. , Horvath S.. , Tinker S.W.. W. 
Published: August 2014

Summary
The work is focused on one of the oldest and largest developed shale-gas plays—the Barnett shale. The primary objective is to bring more clarity and granularity to the Barnett resource estimation. The second task is to develop a resource-estimation methodology that one can use to evaluate other shale-gas plays in an attempt to determine their potential for development.
We compile a comprehensive database, including production histories of more than 16,000 drilled wells and calibrated density log porosity and net-pay-zone-thickness maps. The data are used to estimate (1) the remaining technically recoverable free-gas resource, (2) individual-well recoveries, (3) areas drained by the existing wells, and (4) the future drill-well inventory. On the basis of the geographical distribution of individual-well estimated ultimate recoveries, we divide the Barnett acreage into 10 tiers. We describe the future drill-well inventory for each tier.
In addition, to assess the potential contribution of refracturing to the future Barnett production, we develop a statistical procedure to identify wells that are likely to be refractured and then analyze their performances.
An Integrative Review and Synthesis of XBRL Research in Academic Journals
Authors: Perdana Arif , Robb Alastair , Rohde Fiona 
Published: August 2014

ABSTRACT
Extensible business reporting language (XBRL) was developed from an established markup computer language (eXtensible Markup Language, XML). XBRL facilitates data and information exchange between different information systems (IS). This important feature has attracted much research since the early 2000s. This article aims to provide a framework for XBRL research's contributions to information systems (IS). An integrative review is needed to draw an overall picture and canvas key findings regarding the various XBRL topics examined in past studies. Such a review also identifies research opportunities and guides future XBRL research. We conducted thematic analysis using an integrative literature review. A sample of 150 XBRL articles obtained from various peer-reviewed academic journals was used to understand past XBRL studies and suggest XBRL's future research direction. This article identifies and proposes four current XBRL research streams; namely, XBRL's impact on business, XBRL's adoption, XBRL's technical development, and XBRL education. This paper then examines the key findings of these XBRL papers, offers several potential areas where further investigation may be warranted, and suggests XBRL research-informed practices.
Wear Properties of a Novel Resin Composite Compared to Human Enamel and Other Restorative Materials
Authors: D'Arcangelo C , Vanini L , Rondoni GD , Pirani M , Vadini M , Gattone M , De Angelis F 
Published: August 2014

SUMMARYThe purpose of this in vitro study was to compare the two-body wear resistance of human enamel, a pressable glass-ceramic (Imagine PressX), a type 3 gold alloy (Aurocast8), three resins composites currently available on the market (Enamel plus HRi, Filtek Supreme XTE, Ceram.X duo), and one recently introduced resin composite (Enamel plus HRi-Function). Resin composites were tested after simple light curing and after a further heat polymerization cycle. Ten cylindrical specimens (7 mm in diameter) were manufactured with each dental material according to standard laboratory procedures. Ten flat enamel specimens were obtained from freshly extracted human molars and included in the control group. All samples were subjected to a two-body wear test in a dual-axis chewing simulator over up to 120,000 loading cycles, against yttria stabilized tetragonal zirconia polycrystal cusps. Wear resistance was analyzed by measuring the vertical substance loss (mm) and the volume loss (mm3). Antagonist wear (mm) was also recorded. Data were statistically analyzed using one-way analysis of variance (ANOVA) (wear depth and volume loss) and Kruskal-Wallis one-way ANOVA on ranks (antagonist wear). Heat-cured HRi function and Aurocast8 showed similar mean values for wear depth and volumetric loss, and their results did not statistically differ in comparison with the human enamel.
Influence of a Repeated Preheating Procedure on Mechanical Properties of Three Resin Composites
Authors: D'Amario M , De Angelis F , Vadini M , Marchili N , Mummolo S , D'Arcangelo C 
Published: August 2014

SUMMARY
The aim of this study was to assess the flexural strength, flexural elastic modulus and Vickers microhardness of three resin composites prepared at room temperature or cured after one or repeated preheating cycles to a temperature of 39°C. Three resin composites were evaluated: Enamel Plus HFO (Micerium), Opallis (FGM), and Ceram X Duo (Dentsply DeTrey). For each trial, one group of specimens of each material was fabricated under ambient laboratory conditions, whereas in the other groups, the composites were cured after 1, 10, 20, 30, or 40 preheating cycles to a temperature of 39°C in a preheating device. Ten rectangular prismatic specimens (25 × 2 × 2 mm) were prepared for each group (N=180; n=10) and subjected to a three-point bending test for flexural strength and flexural modulus evaluation. Vickers microhardness was assessed on 10 cylindrical specimens from each group (N=180; n=10). Statistical analysis showed that, regardless of the material, the number of heating cycles was not a significant factor and was unable to influence the three mechanical properties tested. However, a significant main effect of the employed material on the marginal means of the three dependent variables was detected.