bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warburg Effect and Type II Glucose Transporter Inhibitors as a Potential Targeted Therapy for Liver Cancer: A Review
Authors: Sooksawat Dhassida , Boonpech Worarat , Tipmanee Varomyalin , Churuangsuk Chaitong , Srifa Pemikar , Juncheed Kantida 
Published: July 2024

Cancer cells demonstrate enhanced survival owing to the underlying metabolic changes that accelerate tumor growth. Hepatocellular carcinoma (HCC) cells exhibit the Warburg effect, a hallmark of cancer metabolism associated with aberrant proliferation. This review critically assesses the existing obstacles in developing selective type II glucose transporter GLUT-2 inhibitors, examining the inhibition of GLUT-2 by natural extracts and synthesized compounds. Liver cells regulate glucose uptake and release via GLUT-2. Dysregulated GLUT-2 expression in HCC increases glucose absorption and metabolism, thereby fueling tumor growth. Targeting inhibition of GLUT-2 may delay tumor development and improve therapeutic sensitivity by preventing glucose uptake by cancer cells. Natural and synthetic chemicals that specifically limit GLUT-2 activity are promising GLUT-2 inhibitors. GLUT-2 inhibitors must be engineered with precision to specifically target GLUT-2 while avoiding interference with other GLUT functions. Targeted therapy is complicated by difficulties in determining the mechanisms underlying GLUT-2 dysregulation in various malignancies. New HCC treatments require a deep understanding of GLUT-2 and cancer metabolism as well as advances in pharmacological research and development. Conclusively, the targeting of GLUT-2 is a novel therapeutic strategy for HCC. Understanding the intricate role of GLUT-2 in the pathophysiology of HCC may lead to the development of tailored therapies for patients with HCC.
HIGHLIGHTS

The Warburg effect, which emphasizes upregulated glucose metabolism in cancer cells, is a potential therapeutic target for liver cancer
Class I glucose transporters are more expressed in liver cancer cells than in normal cells
The Warburg effect is crucial for cancer cell metabolism and is related to cancer hallmarks such as cell proliferation, metastasis, and invasion
Compounds that specifically inhibit glucose transporter type II can impair the energy production pathway critical for hepatocellular carcinoma cell survival

GRAPHICAL ABSTRACT
ELASTISITAS DEMAND DAN SUPPLY BARANG TERHADAP HARGA DI KOTA LHOKSEUMAWE (Studi Kasus atas Persepsi para Milenial)
Authors: Marzalina Marzalina , Haryani Haryani , Asrida Asrida 
Published: July 2024

The research was carried out descriptively quantitatively, with a questionnaire instrument on a sample of millennials in the city of Lhokseumawe. The results of respondents' perceptions show that the law and the meaning of market demand are still low. Likewise, regarding the meaning and law of bidding, around 30% still do not understand it exactly. Regarding the theory about setting and changing commodity prices, 52% understand it and the rest don't understand it and don't bother about it. In general, the elasticity of demand and supply for the price of goods is still more than 40%, which is not yet understood precisely. The results of quantitative analysis using a statistical test approach explain that there is no significant influence between the elasticity of demand and supply on price variables.
Virtual reality in construction activities: barriers for adoption in China
Authors: HONG JINGQING , Akotia Julius , Charles Egbu 
Published: July 2024

Purpose - The research presents a study of the barriers that hamper industry adoption of Virtual Reality (VR) for construction activities in China.
Design/methodology/approach - The research adopted a qualitative research methodology, using semi-structured interviews to collect data from participants. The initial set of codes was established through an open coding method for the subsequent content analysis of data.
Findings - The findings obtained identified the economic issue as the main barrier impeding the adoption of VR to deliver construction projects in China. Other barriers were also identified including insufficient technical depth and awareness, and the fragmented nature of the supply chain within the industry.
Originality/value - The study proposed recommendations on raising awareness, setting up workflows and government support to mitigate the limiting barriers. The findings of the study provide valuable insights to researchers and Chinese construction industry practitioners to better understand and promote VR adoption in the delivery of construction projects.
An in-depth investigation of digital construction technologies from a building economics perspective
Authors: Irlayici Cakmak Pinar , Akturk Berkay 
Published: July 2024

While initial costs in building economics cover a small portion of the costs incurred during its life-cycle, most occur in construction, operation, and subsequent processes. Despite its numerous contributions to building economics, the construction industry is slowly adapting to digital technologies. To overcome the barriers and crown the assets with their proper management, dynamic applications of digital tools and techniques of Industry 4.0 need to emerge in the construction industry. Therefore, this study aims to present an integrative approach that combines quantitative and qualitative analysis techniques to critically review the available literature on the potential contributions of digital construction technologies to building economics through the post-design phases of the life cycle. The primary focus of the investigation is how digital technologies can overcome prevalent problems and how they can impact building economics. The study contributes to the field by providing an awareness that will inform researchers and practitioners of the trends, gaps, and more profound exchange of ideas in future research efforts.
Innovative digital marketing strategies for SMEs: Driving competitive advantage and sustainable growth
Authors: Tochukwu Ignatius Ijomah  , Courage Idemudia  , Nsisong Louis Eyo-Udo  , Kikelomo Fadilat Anjorin  
Published: July 2024

In the rapidly evolving digital landscape, small and medium-sized enterprises (SMEs) must adopt innovative digital marketing strategies to drive competitive advantage and sustainable growth. This review explores the critical components and benefits of leveraging digital marketing for SMEs, emphasizing how tailored strategies can enhance market presence, customer engagement, and business performance. SMEs face unique challenges in resource allocation and market competition, necessitating cost-effective and impactful marketing approaches. Innovative digital marketing strategies, including search engine optimization (SEO), social media marketing, content marketing, email campaigns, and data-driven analytics, provide SMEs with the tools to compete effectively against larger enterprises. By utilizing these strategies, SMEs can achieve greater visibility, attract a broader audience, and convert prospects into loyal customers. SEO and content marketing play a pivotal role in enhancing online visibility and organic traffic. By producing high-quality, relevant content and optimizing it for search engines, SMEs can improve their search rankings and attract targeted audiences. Social media platforms offer powerful channels for engaging with customers, building brand awareness, and fostering community. Through targeted advertisements and influencer partnerships, SMEs can reach specific demographics and drive engagement. Email marketing remains a cost-efficient strategy for maintaining customer relationships and promoting products or services. Personalized email campaigns can nurture leads, encourage repeat business, and build customer loyalty. Additionally, data-driven analytics enable SMEs to measure campaign performance, understand customer behavior, and make informed decisions to refine marketing efforts. The integration of innovative technologies such as artificial intelligence (AI) and machine learning further enhances digital marketing capabilities. AI-driven tools can automate tasks, provide insights into customer preferences, and optimize marketing strategies in real-time. For instance, chatbots can improve customer service, while predictive analytics can forecast trends and personalize marketing messages. In conclusion, innovative digital marketing strategies are essential for SMEs seeking to drive competitive advantage and sustainable growth. By embracing SEO, social media marketing, content marketing, email campaigns, and data-driven analytics, SMEs can maximize their marketing impact, enhance customer engagement, and achieve long-term business success. Leveraging these strategies allows SMEs to remain agile, responsive, and competitive in the dynamic digital marketplace.
Keywords: Innovative, Digital Marketing, SMEs, Sustainable Growth, Competitive Advantage.
Estratégias de aprendizagem: o uso de metodologias ativas na formação e na qualificação de preceptores.
Authors: Oliveira de Carvalho Jacqueline , Vieira Lourenço Letícia , Da Costa de Jesus Michelle Adrianne , Pacheco Teixeira Carla 
Published: July 2024

Objetivo: Narrar a experiência sobre o uso de metodologias ativas na formação e na qualificação de preceptores do Programa de Residência em Enfermagem de Família e Comunidade. Método: Trata-se de um relato de experiência do projeto de qualificação. Foram realizadas onze qualificações, divididas em três módulos: aprimoramento das habilidades de preceptoria; treinamentos direcionados para a prática clínica e eventos científicos visando a formação crítica e complementar, todos desenvolvidos a partir do uso de metodologias ativas. O estudo contou com a participação de 100 enfermeiros preceptores no período de outubro de 2021 a março de 2023. Conclusão: Esta experiência demonstrou a importância em considerar o pressuposto da Educação Permanente para a qualificação do SUS. O uso das metodologias ativas na formação, ofereceu aos preceptores as habilidades e conhecimentos necessários para criar um ambiente de aprendizagem mais interativo e participativo nos serviços de saúde, bem como nas relações didáticas com os residentes em formação.
Hopfield Type Phase Neural Network
Authors: Крыжановский Б. В. 
Published: July 2024

исследованы свойства полносвязной нейронной сети, построенной на фазовых нейронах по правилу Хэбба. Сигналы, протекающие по межсвязям сети, представляют собой единичные импульсы с определенными фазами. Решающее правило срабатывания нейрона задается следующим образом: в суммарном сигнале, поступающем на вход нейрона, выделяется фазовая компонента с наибольшей амплитудой, и нейрон испускает единичный импульс с такой же фазой. Фазы, кодирующие компоненты векторов ассоциативной памяти, распределены случайным образом. Для оценки ошибки распознавания применяется техника Чернова–Чебышёва, не зависящая от типа распределения кодирующих фаз. Показано, что объем ассоциативной памяти такой нейросети в четыре раза больше, чем у классической сети хопфилдова типа, оперирующей бинарными паттернами. Соответственно, в четыре раза больше и радиус области притяжения.
this study examines the properties of a fully connected neural network composed of phase neurons, following the Hebbian learning rule. The signals transmitted through the network’s interconnections are single pulses with specific phases. A neuron’s firing rule is defined as follows: among the total signals received at a neuron’s input, the phase component with the highest amplitude is identified, and the neuron emits a single pulse with the same phase. The phases encoding the components of associative memory vectors are randomly distributed. To estimate the recognition error, we employ the Chernov-Chebyshev technique, which is independent of the phase encoding distribution type. Our findings demonstrate that the associative memory capacity of this neural network is four times greater than that of a traditional Hopfield network that operates with binary patterns. Consequently, the radius of the attraction region is also four times larger.
Detection of Data Modifications in Corporate Networks Using a Confidence Coefficient
Authors: Жебель В. А. , Солдатов А. И. 
Published: July 2024

в статье представлены исследования в рамках защиты сетевого трафика от атак на целостность, также предложен метод определения достоверности передаваемых данных по компьютерной сети предприятия. Предложенный метод основан на использовании проверочных пакетов для анализа активности сети предприятия. В работе приведено детальное описание инструментов, используемых для реализации данного метода. Эти инструменты включают в себя программное обеспечение, разработанное на языке программирования Python 3 для серверной части с применением сетевых библиотек Scapy и Socket, а также клиентскую программу для рабочей станции. В статье также рассматриваются выявленные проблемы, возникшие в процессе исследования коэффициента достоверности данных. Предложен подход для их решения при расчете данного коэффициента. Кроме того, описаны основные аспекты качественных и количественных критериев для оценки коэффициента достоверности и рассмотрена методика их расчета. В заключении приведены обобщенные результаты исследования, оценка эффективности используемого программного обеспечения, а также представлены схемы и алгоритмы функционирования предложенного метода в сетевой среде.
this article presents research focused on protecting network traffic from integrity attacks and introduces a method for determining the reliability of transmitted data within corporate networks. The proposed method utilizes verification packets to analyze network activity. A comprehensive description of the tools used to implement this method is provided, including the server side software developed in Python 3, leveraging the Scapy and Socket network libraries, and a workstation client. The article also addresses the challenges encountered during the study of the data reliability coefficient and suggests solutions for these issues. Additionally, the article outlines the main aspects of qualitative and quantitative criteria for assessing the reliability coefficient and details their estimation methods. The conclusion presents the overall results of the study, evaluates the performance of the software used, and describes possible applications of the proposed method in network environments.
CONTRIBUIÇÕES DO PIBID INTERDISCIPLINAR HISTÓRIA E GEOGRAFIA: O OLHAR DO PROFESSOR SUPERVISOR
Authors: Rodrigues Elisângela de Azevedo Silva 
Published: July 2024

Este trabalho tem como objetivo apresentar as contribuições e a qualificação de conhecimentos adquiridos com as formações docentes do Programa Institucional de Bolsa de Iniciação à docência–PIBID, subprojeto interdisciplinar História e Geografia com enfoque nas relações étnico-raciais na Escola de Educação Básica da Universidade Federal de Uberlândia, entre dezembro de 2022 e abril de 2024. Utilizou-se, como procedimento metodológico, a análise documental (Lüdke e André, 1986) para examinar, dentre outros documentos, o relatório de conclusão do Programa, elaborado pelo supervisor, autor deste trabalho. A análise revelou que as atividades desenvolvidas, ao longo do PIBID, fomentaram as três dimensões consideradas neste estudo, quais sejam: a formação continuada, a interdisciplinaridade e a relação teoria-prática. Os resultados sugerem que o programa ampliou a interlocução entre a universidade e a escola-campo, contribuindo para a qualidade da formação docente de todos os envolvidos no programa, sejam eles os IDs e os docentes, coordenadores e supervisores.
Неопубликованные материалы к обсуждению «Истории Казахской ССР» 1943 года: выступление А.Х. Маргулана
Authors: Жумашев Рымбек Муратович , Бедельбаева Марина Васильевна 
Published: July 2024

Личность академика А.Х. Маргулана, 120-летие со дня рождения которого отмечается в этом году, является знаковой для казахстанской науки и вызывает пристальный интерес исследователей в силу своей многогранности. В статье анализируется неопубликованный ранее архивный документ, содержащий стенограмму выступления А.Х. Маргулана на заседании Ученого совета Института истории АН СССР (г. Москва, 1945 г.) по поводу обсуждения книги «История Казахской ССР с древнейших времен до наших дней», изданной в 1943 г. Высшее партийное руководство страны осудило концепцию истории Казахстана, обвинив коллектив авторов в проявлениях буржуазного национализма и отходе от марксистско-ленинской теории. А.Х. Маргулан, который был одним из авторов и написал раздел об истории Золотой орды, стал единственным учёным, отстаивавшим свою позицию и научные выводы. Данный документ подтверждает характеристику А.Х. Маргулана как учёного, непримиримого к властному давлению, способного отстаивать принципиальные постулаты. Материалы статьи конкретизируют научную биографию академика и процесс его становления как учёного-археолога.
Лошади из раннетюркских погребений: по материалам памятника Самсы
Authors: Шагирбаев Мамбет Сапарбекович , Буранбаев Руслан Нурланович , Шербаев Руслан Кудайбергенович 
Published: July 2024

Целью работы является археозоологическое изучение останков шести лошадей из четырёх курганов памятника Самсы (ІХ-Х в.). Научная новизна заключается в первых исследованиях морфологических показателей лошадей из древнетюркских памятников Казахстана. Лабораторные исследования проводились на основе общепринятых методик: морфологический, биометрический и палеопатологический анализ скелетов и их отдельных элементов. Также были сделаны спилы коренных зубов для определения сезона гибели лошадей. В результате были получены данные о том, что в погребальном обряде раннетюркского времени использовали животных разного возраста от 3-х до 16 лет. Пять из шести особей являлись жеребцами, по шестому скелету пол не определён. Лошади были ниже среднего и среднего роста и принадлежали к группе разных типов тонконогости. Захоронения проводились весной и осенью. По своим абсолютным размерам лошади памятника Самсы близки к лошадям из средневековых городов Южного Казахстана и Жетысу. Также исследованы кости овцы и собаки. Определены их высота в холке и возраст. По материалам аналогичных захоронений с конём в Шу-Илейском междуречье выяснилось, что основная часть индивидов здесь ориентирована головой в северный сектор, в то время как кони – в противоположную (южную) сторону.
Архитектурные традиции элитных комплексов поздней бронзы Сарыарки
Authors: Рысбергенов Муса Ахатулы , Хабдулина Марал Калымжановна , Брынза Татьяна Васильевна 
Published: July 2024

Работа посвящена анализу элитных погребальных конструкций Сарыарки – так называемых курган-оград. В ХХ столетии считалось, что элитные погребальные комплексы данного типа не относятся к памятникам андроновской общности и рассматривались как раннебегазинские или как памятники особого переходного времени. В последние десять лет на территории Сарыарки возобновилось изучение социально-стратифицированных памятников. В связи с появлением новых данных наметилась возможность пересмотреть интерпретацию курган-оград. В представленной статье на основе подробной характеристики и осуществления обобщающего анализа обосновывается принадлежность этих сооружений фёдоровской культуре. Помимо этого, анализ всех основных признаков позволил разделить комплексы на две хронологические группы – ранние (XVII – 1 пол. XVI в. до н.э.) и поздние (2 пол. XVI – 1 пол. XV в. до н.э.).
PENGUATAN PENDIDIKAN GENDER (TELA’AH KRITIS DALAM PERSPEKTIF ISLAM)
Authors: Ahmad Riad  , Faizaluddin  , Romaida  
Published: July 2024

Dalam berbagai diskursus gender dan dikuatkan melalui pranata sosial, dimana laki-laki dan perempuan dibedakan sesuai dengan perannya masing-masing, yang di konstruksikan oleh kultur setempat, yang berkaitan dengan peran, sifat, kedudukan dan posisi dalam masyarakat tersebut. Pembedaan peran ini dalam pranata sosial digambarkan bahwa perempuan hanya boleh memerankan pekerjaan domestik (kasur, sumur dan dapur), sementara laki-laki layak memerankan pekerjaan publik. Dalam konsep gender, sesungguhnya perbedaan gender tidak akan menjadi masalah selama tidak melahirkan ketidakadilan gender, namun yang menjadi persoalan ternyata perbedaan gender telah melahirkan berbagai ketidakadilan. Studi-studi tentang gender saat ini melihat bahwa ketimpangan gender terjadi akibat rendahnya kualitas sumberdaya kaum perempuan sendiri, dan hal tersebut mengakibatkan ketidakmampuan mereka bersaing dengan kaum lelaki. Ironisnya, agama dibawa-bawa sebagai patron utama dalam kemunculan berbagai permasalahan ketidakadilan gender Oleh karena itu upaya-upaya yang dilakukan adalah mendidik kaum perempun dan mengajak mereka berperan dalam pembangunan. Dalam realitas yang kita jumpai pada masyarakat tertentu terdapat adat kebiasaan yang tidak mendukung dan bahkan melarang keikutsertaan perempuan dalam pendidikan formal. Bahkan ada paradigma yang mengemuka bahwa “perempuan tidak perlu sekolah tinggi-tinggi karena akhirnya ke dapur juga.” Dalam konteks di atas, penguatan pendidikan gender masih perlu dijawab dan dikaji salah satunya melalui perspektif pendidikan itu sendiri. Tujuan penelitian ini adalah untuk mengetahui dan menganalisis konsep gender dalam perspektif pendidikan serta berusaha mendeskripsikan penguatan pendidikan berbasis keadilan gender. Jenis Metode yang digunakan dalam penelitian ini adalah penelitian studi pustaka. Data yang telah diperoleh dikompulasikan, dianalisis, dan disimpulkan sehingga mendapatkan kesimpulan mengenai masalah yang dibahas. Hasil penelitian ini menunjukkan bahwa konsep gender berbasis pendidikan merupakan hal yang penting untuk dipraktikkan di kehidupan sehari-hari dalam kehidupan berkeluarga, maupun bermasyarakat. Karena pendidikan berbasis konsep gender ini telah banyak dibicarakan dalam Al-Qur’an dan Hadist sehingga tidak memiliki keraguan sedikit pun tentang keadilan gender dalam Islam.
Internalisasi Nilai-Nilai Moderasi Beragama Dalam Kurikulum Merdeka Belajar Pendidikan Agama Islam
Authors: Hilmin  , Dwi Noviani  , Eka Yanuarti  
Published: July 2024

Penelitian ini bertujuan mendeskripsikan internalisasi nilai-nilai moderasi beragama dalam kurikulum merdeka pendidikan agama Islam. Adapun metode pada penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kepustakaan. Pengumpulan data diperoleh melalui pencermatan terhadap literatur terkait berupa artikel, buku, dokumen, kebijakan, maupun pencermatan terhadap literatur online. Selanjutnya melakukan pendekatan interpretasi dengan mengkaji data-data pada evidensi objektif, untuk mencapai kebenaran otentik. Interpretasi di sini bahan atau data-data yang sudah dideskripsikan, kemudian diinterpretasikan dan dianalisis kembali untuk menunjukan dan memperjelas tentang nilai-nilai moderasi beragama dalam kurikulum merdeka belajar pendidikan agama Islam secara objektif, runtut, komprehensif, dan mendasar. Hasil penelitian menunjukkan korelasi yang kuat dan saling menguatkan bahwa nilai-nilai moderasi beragama dapat diinternalisasikan ke dalam kurikulum merdeka pendidikan agama islam. Desain kurikulum merdeka untuk pendidikan agama islam sebagai bagian penting untuk memperkuat moderasi beragama dalam kehidupan masyarakat. Prinsip-prinsip yang terkandung di dalam kurikulum merdeka sangat selaras dengan nilai-nilai pemikiran moderasi beragama. Kurikulum merdeka pendidikan agama islam sangat membutuhkan kerangka konsep dan dasar pemikiran yang moderat dan kontekstual.
The Scholarly Ustad: Hindustani Music's Muslim Hereditary Professionals and Their Textual Traditions
Authors: Katz Max 
Published: July 2024

AbstractHindustani music's Muslim hereditary professional performers—known as ustād-s—have long been depicted as essentially nonliterate. Colonial and nationalist texts condemned the ustads for their ignorance and illiteracy; latter-day ethnomusicological texts celebrate the same ustads for their orality and embodiment. Based on original translations of twentieth-century sources in Urdu, Hindi, and Bengali, this article highlights a contrasting dimension of the Muslim hereditary tradition in Hindustani music: a three-hundred-year commitment by the ustads themselves to the saṅgītaśāstra, a succession of technical musical treatises traceable to antiquity.