bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNORA28 Promotes Proliferation and Radioresistance in Colorectal Cancer Cells through the STAT3 Pathway by Increasing H3K9 Acetylation in the LIFR Promoter
Authors: Liu Xin , Zhang Hong , Fan Ying , Cai Dan , Lei Ridan , Wang Qi , Li Yaqiong , Shen Liping , Gu Yongqing , Zhang Qingtong , Qi Zhenhua , Wang Zhidong 
Published: June 2024

AbstractRadiotherapy is essential for treating colorectal cancer (CRC), especially in advanced rectal cancer. However, the low radiosensitivity of CRC cells greatly limits radiotherapy efficacy. Small nucleolar RNAs (snoRNAs) are a class of noncoding RNA that primarily direct post‐transcriptional modifications of ribosomal RNAs (rRNAs), small nuclear RNAs (snRNAs), and other cellular RNAs. While snoRNAs are involved in tumor progression and chemoresistance, their association with radiosensitivity remains largely unknown. Herein, SNORA28 is shown highly expressed in CRC and is positively associated with poor prognosis. Furthermore, SNORA28 overexpression enhances the growth and radioresistance of CRC cells in vitro and in vivo. Mechanistically, SNORA28 acts as a molecular decoy that recruits bromodomain‐containing protein 4 (BRD4), which increases the level of H3K9 acetylation at the LIFR promoter region. This stimulates LIFR transcription, which in turn triggers the JAK1/STAT3 pathway, enhancing the proliferation and radioresistance of CRC cells. Overall, these results highlight the ability of snoRNAs to regulate radiosensitivity in tumor cells and affect histone acetylation modification in the promoter region of target genes, thus broadening the current knowledge of snoRNA biological functions and the mechanism underlying target gene regulation.
Phase 3 randomized COMMODORE 1 trial: Crovalimab versus eculizumab in complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria
Authors: Scheinberg Phillip , Clé Diego Villa , Kim Jin Seok , Nur Erfan , Yenerel Mustafa N. , Barcellini Wilma , Bonito Debora , Giai Valentina , Hus Marek , Lee YooJin , Lekue Cristina Barrenetxea , Panse Jens , Ueda Yasutaka , Buatois Simon , Gentile Brittany , Kiialainen Anna , Patel Himika , Sreckovic Sasha , Uguen Marianne , Edwards John , Nagy Zsolt , Kulasekararaj Austin G. 
Published: June 2024

AbstractCrovalimab, a novel C5 inhibitor, allows for low‐volume, every‐4‐ week, subcutaneous self‐administration. COMMODORE 1 (NCT04432584) is a phase 3, global, randomized trial evaluating crovalimab versus eculizumab in C5 inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria (PNH). Adults with lactate dehydrogenase ≤1.5 × upper limit of normal and receiving approved eculizumab doses for ≥24 weeks were randomized 1:1 to receive crovalimab (weight‐based tiered dosing) or continue eculizumab. The original primary study objective was efficacy; however, given the evolving treatment landscape, target recruitment was not met, and all efficacy endpoints became exploratory, with safety as the new primary objective. Exploratory efficacy endpoints included transfusion avoidance, hemolysis control, breakthrough hemolysis, hemoglobin stabilization, FACIT‐Fatigue score, and patient preference (crovalimab vs. eculizumab). Eighty‐nine patients were randomized (45 to crovalimab; 44 to eculizumab). During the 24‐week primary treatment period, adverse events (AEs) occurred in 77% of patients receiving crovalimab and 67% receiving eculizumab. No AEs led to treatment withdrawal or death, and no meningococcal infections occurred. 16% of crovalimab‐treated patients had transient immune complex reactions (also known as Type III hypersensitivity events), an expected risk when switching between C5 inhibitors that bind to different C5 epitopes; most were mild/moderate and all resolved without treatment modification. Crovalimab‐treated patients had sustained terminal complement activity inhibition, maintained disease control, and 85% preferred crovalimab over eculizumab. Together with phase 3 COMMODORE 2 results in complement inhibitor‐naive patients, these data support crovalimab's favorable benefit–risk profile. Crovalimab is a new C5 inhibitor for PNH that is potentially less burdensome than existing therapies for this lifelong disease.
An ANXA11 P93S variant dysregulates TDP‐43 and causes corticobasal syndrome
Authors: Snyder Allison , Ryan Veronica H. , Hawrot James , Lawton Sydney , Ramos Daniel M. , Qi Y. Andy , Johnson Kory R. , Reed Xylena , Johnson Nicholas L. , Kollasch Aaron W. , Duffy Megan F. , VandeVrede Lawren , Cochran J. Nicholas , Miller Bruce L. , Toro Camilo , Bielekova Bibiana , Marks Debora S. , Yokoyama Jennifer S. , Kwan Justin Y. , Cookson Mark R. , Ward Michael E. 
Published: June 2024

AbstractINTRODUCTIONVariants of uncertain significance (VUS) surged with affordable genetic testing, posing challenges for determining pathogenicity. We examine the pathogenicity of a novel VUS P93S in Annexin A11 (ANXA11) – an amyotrophic lateral sclerosis/frontotemporal dementia‐associated gene – in a corticobasal syndrome kindred. Established ANXA11 mutations cause ANXA11 aggregation, altered lysosomal‐RNA granule co‐trafficking, and transactive response DNA binding protein of 43 kDa (TDP‐43) mis‐localization.METHODSWe described the clinical presentation and explored the phenotypic diversity of ANXA11 variants. P93S's effect on ANXA11 function and TDP‐43 biology was characterized in induced pluripotent stem cell‐derived neurons alongside multiomic neuronal and microglial profiling.RESULTSANXA11 mutations were linked to corticobasal syndrome cases. P93S led to decreased lysosome colocalization, neuritic RNA, and nuclear TDP‐43 with cryptic exon expression. Multiomic microglial signatures implicated immune dysregulation and interferon signaling pathways.DISCUSSIONThis study establishes ANXA11 P93S pathogenicity, broadens the phenotypic spectrum of ANXA11 mutations, underscores neuronal and microglial dysfunction in ANXA11 pathophysiology, and demonstrates the potential of cellular models to determine variant pathogenicity.Highlights
ANXA11 P93S is a pathogenic variant.
Corticobasal syndrome is part of the ANXA11 phenotypic spectrum.
Hybridization chain reaction fluorescence in situ hybridization (HCR FISH) is a new tool for the detection of cryptic exons due to TDP‐43‐related loss of splicing regulation.
Microglial ANXA11 and related immune pathways are important drivers of disease.
Cellular models are powerful tools for adjudicating variants of uncertain significance.
Investigation on UV/flame retardant protection of outdoor‐applied cotton fabrics by tannic acid/phytic acid system
Authors: Liu Wei , Liu Shuping , Ma Jingjing , Zeng Yuan , Liu Rangtong 
Published: June 2024

AbstractThe ultraviolet/flame retardant protection cotton fabric is successfully prepared using a spray baking process with tannic acid (TA) and phytic acid (PA) as key ingredients to address the issues of cotton fabric such as high flammability and lack of ultraviolet (UV) resistance. With respect to the treated fabric by 4 wt% PA solution and 3 wt% TA solution, it presented 29.5% limited oxygen index (LOI) value, 8.0 cm damaged length and 26.4 ultraviolet protection factor (UPF), while they were 28.3%, 7.5 cm and 30.6 for treated fabric by 3 wt% PA solution and 4 wt% TA solution, which indicated that in the mixed system, although TA primarily acted as an anti‐UV agent, it also exhibited flame retardant properties, and PA primarily functioned as a flame retardant and could provide a certain degree of UV protection. The prepared cotton fabric through this facile method presented excellent UV/flame retardant protection capabilities, and improved the functional efficiency of TA and PA materials. Moreover, as‐prepared fabric showed great application potential, especially in outdoor‐applied fields such as sportswear, sunshade tents, sunshade hats, and so on.
Research progress of multifunctional anti‐icing composites materials
Authors: Zhang Haonan , Guo Huangying , Jiang Rijia , Wan Wenyu , Deng Pengcheng , Zhou Xing 
Published: June 2024

AbstractThe accumulation of ice and snow will have a great impact on industry and people's lives. People usually adopted active deicing method for deicing in the past, which is characterized by high energy consumption, low efficiency, and high cost. Passive anti‐icing materials are the most widely used due to their low icing adhesion strength and energy saving, but passive anti‐icing materials tend to lose anti‐icing performance after mechanical damage or following exposure to harsh environments resembling low temperatures, high humidity. Recently, new anti‐icing materials have been rationally designed through the combination of passive and active anti‐icing, exhibiting high‐efficiency and energy‐saving anti‐icing properties. The design idea is that low surface energy polymers combine photothermal and electrothermal particles to achieve photothermal and electrothermal superhydrophobic anti‐icing. Anti‐icing materials are easily damaged after long‐term outdoor use, so the self‐healing capabilities of the materials are important. This review briefly introduces the ice formation mechanism and anti‐icing methods, focusing on the recent progress in the structural design of superhydrophobic, photothermal, electrothermal, and self‐healing anti‐icing materials. The design of the new generation of anti‐icing materials will be a combination of active and passive anti‐icing, which can achieve ideal all‐weather anti‐icing and deicing and repair the damage during long‐term use.
Cellular metabolomics study of the antitumor mechanism of Sijunzi decoction combined with mitomycin C
Authors: Zhang Zhiru , Chen Yu , Bian Yanggang , Wang Tian Tian , Wang Miao 
Published: June 2024

AbstractMitomycin C (MMC) has an antitumor effect and is considered as a broad‐spectrum antibiotic. Sijunzi Decoction (SJZD), a well‐known ancient Chinese prescription, is widely used in the treatment of cancer when combined with chemotherapy drugs. Studies have shown that SJZD can be combined with other drugs to enhance the therapeutic effect against cancer and inhibit the toxicity of chemotherapy drugs, but the specific mechanism is not clear. Thus, we hope to further explore the antitumor mechanism of combined SJZD and MMC. 3‐(4,5‐Dimethyl‐2‐thiazolyl)‐2, 5‐diphenyl‐2‐H‐tetrazolium bromide assay, flow cytometry, western blot, 1H NMR and HPLC–MS were used to study the mechanism at the cellular level. The results show that the combined administration can have a more significant effect on inhibiting the proliferation of cancer cells, promoting their apoptosis. Based on metabolomics, 38 biomarkers were found in the MMC group and 43 biomarkers were found in the combined administration group. Among them, 18 unique biomarkers were discovered in the combined administration group. Studies have shown that the antitumor mechanism of combined administration is related to amino acid metabolism, energy metabolism, lipid metabolism and nucleotide metabolism, among which amino acid metabolism is the most important. In addition, SJZD achieves the effect of toxin reduction and efficiency enhancement by improving the body's immunity and improving the oxidative stress environment.
Visible Light‐Mediated Late‐Stage Thioetherification of Mercaptopurine Derivatives
Authors: Ge Yuhua , Peng Yijiang , Xie Ruoqian , Luo Yang , Li Yangyan , Chen Gang 
Published: June 2024

AbstractWe disclose herein a novel and general radical approach to alkylthiopurines, encompassing 4 types of thiopurines, as well as their corresponding ribosides. This strategy is achieved through visible light‐mediated late‐stage functionalization of the sulfur atoms of mercaptopurines. The in situ‐generated disulfide was proposed as the pivotal neutral intermediate for this transformation. We present herein a novel photo‐mediated homolytic C−S bond formation for the preparation of alkylthiopurines and alkylthiopurine nucleosides. Despite the presence of reactive sites for the Minisci reaction, chemoselective S‐alkylation remained the predominant pathway. This method allows for the late‐stage introduction of a broad spectrum of alkyl groups onto the sulfur atom of unprotective mercaptopurine derivatives, encompassing 2‐, 6‐, and 8‐mercaptopurine rings. Organoborons serve as efficient and eco‐friendly alkylating reagents, providing advantages in terms of readily availability, stability, and reduced toxicity. Further derivatization of the thioetherified nucleosides, together with anti‐tumor assays, led to the discovery of potent anti‐tumor agents with an IC50 value reaching 6.1 μM (Comp. 31 for Jurkat).
Supramolecular Complexation‐Enhanced CO2 Chemisorption in Amine‐Derived Sorbents
Authors: Li Errui , Li Bo , Ganesan Arvind , Qiu Liqi , Jiang De‐en , Mahurin Shannon M. , Pramanik Subhamay , Popovs Ilja , Yang Zhenzhen , Dai Sheng 
Published: June 2024

AbstractA supramolecular complexation approach is developed to improve the CO2 chemisorption performance of solvent‐lean amine sorbents. Operando spectroscopy techniques reveal the formation of carbamic acid in the presence of a crown ether. The reaction pathway is confirmed by theoretical simulation, in which the crown ether acts as a proton acceptor and shuttle to drive the formation and stabilization of carbamic acid. Improved CO2 capacity and diminished energy consumption in sorbent regeneration are achieved.
Early Life Surgency, but not Effortful Control or Negative Affectivity, Is a Mediating Variable Between Maternal Pre‐Pregnancy Body Mass Index and Childhood Obesity Risk
Authors: Cho Nicole A. , Giesbrecht Gerald F. , Dewey Deborah , Reimer Raylene A. 
Published: June 2024

ABSTRACTMaternal gestational obesity is related to risk of obesity in the child. This risk may be in part mediated by altered child temperament, which can affect mother–child interactions, including feeding and soothing behaviors that affect obesity risk. Our objective was to examine the association between maternal pre‐pregnancy BMI and child zBMI and determine if child temperament, specifically positive Affectivity/Surgency, mediates this association. Using conditional process modeling, we analyzed data from 408 mother–child dyads enrolled in the Alberta Pregnancy Outcomes and Nutrition (APrON) study. Child temperament was assessed at 3 years of age via a parent report measure, the Child Behavior Questionnaire (CBQ), and child zBMI was calculated from in‐person measurements of child height and weight at 4–5 years of age. Bivariate correlations showed that there was a significant positive correlation between zBMI and Surgency (r = 0.11, p = 0.03), and zBMI was also correlated with maternal pre‐pregnancy BMI (r = 0.12, p = 0.02). Multivariable regression revealed that maternal pre‐pregnancy BMI (adjusted β = 0.15, 95% confidence interval [CI]; 0.00–0.05, p = 0.02) and Surgency scores (adjusted β = 0.14, 95% CI; 0.02–0.28, p = 0.03) were associated with higher child zBMI at 4–5 years of age. Mediation analysis showed that Surgency mediated the association between pre‐pregnancy BMI and child zBMI. Our models controlled for maternal gestational weight gain, gestational diabetes, socioeconomic status, maternal anxiety and depression, and gestational age at birth. Overall, maternal pre‐pregnancy BMI was positively associated with child zBMI, and this association was mediated by higher child Surgency scores.
Feasibility of an Online Acute Stressor in Preschool Children of Mothers with Depression
Authors: Paton Allyson , Stienwandt Shaelyn , Penner‐Goeke Lara , Giuliano Ryan J. , Roos Leslie E. 
Published: June 2024

ABSTRACTMaternal depression is a risk factor for future mental health problems in offspring, with stress‐system function as a candidate vulnerability factor. Here we present initial validation of an online matching‐task (MT) paradigm in young children exposed to maternal depression (N = 40), a first in stressor‐paradigm research for this age group. Investigations of stress‐system reactivity that can be conducted online are an innovative assessment approach, accelerated by the COVID‐19 pandemic. Results indicate high feasibility, with a >75% data collection success rate across measures, similar‐to or better‐than in‐person success rates in young children. Overall, the online MT elicited significant heart rate but not cortisol reactivity. Individual differences in child mental health symptoms were a moderator of reactivity to the stressor such that children with lower, but not higher, behavioral problems exhibited the typical pattern of cortisol reactivity to the online MT. Results are aligned with allostatic load models, which suggest downregulation of stress‐system reactivity as a result of experiencing adversity and mental health vulnerability. Consistent with in‐person research, this suggests that an early phenotype for the emergence of behavior problems may be linked to altered stress‐system reactivity. Results hold potential clinical implications for intervention development and the future of online stress‐system research.Trial Registration: Clinical Trial Registration: NCT04639557; (Building Regulation in Dual Generations—Telehealth Model [BRIDGE]).
Digital reconstruction of three‐dimensional contours and its application to microstructural evaluation of postblast rock fissure surfaces
Authors: Wang Yanbing , Wang Zhaoyang , Fu Dairui , Gang Mingwei 
Published: June 2024

AbstractFracture surface contour study is one of the important requirements for characterization and evaluation of the microstructure of rocks. Based on the improved cube covering method and the 3D contour digital reconstruction model, this study proposes a quantitative microstructure characterization method combining the roughness evaluation index and the 3D fractal dimension to study the change rule of the fracture surface morphology after blasting. This method was applied and validated in the study of the fracture microstructure of the rock after blasting. The results show that the fracture morphology characteristics of the 3D contour digital reconstruction model have good correlation with the changes of the blasting action. The undulation rate of the three‐dimensional surface profile of the rock is more prone to dramatic rise and dramatic fall morphology. In terms of tilting trend, the tilting direction also shows gradual disorder, with the tilting angle increasing correspondingly. All the roughness evaluation indexes of the rock fissure surface after blasting show a linear and gradually increasing trend as the distance to the bursting center increases; the difference between the two‐dimensional roughness evaluation indexes and the three‐dimensional ones of the same micro‐area rock samples also becomes increasingly larger, among which the three‐dimensional fissure roughness coefficient JRC and the surface roughness ratio Rs display better correlation. Compared with the linear fitting formula of the power function relationship, the three‐dimensional fractal dimension of the postblast fissure surface is fitted with the values of JRC and Rs, which renders higher correlation coefficients, and the degree of linear fitting of JRC to the three‐dimensional fractal dimension is higher. The fractal characteristics of the blast‐affected region form a unity with the three‐dimensional roughness evaluation of the fissure surface.
Fungal composition associated with host tree identity mediates nutrient addition effects on wood microbial respiration
Authors: Hu Zhenhong , Fernández‐Martínez Marcos , He Qinsi , Xu Zhiyuan , Jiang Lin , Zhou Guiyao , Chen Ji , Nie Ming , Yu Qiang , Feng Hao , Huang Zhiqun , Michaletz Sean T. 
Published: June 2024

AbstractFungi are key decomposers of deadwood, but the impact of anthropogenic changes in nutrients and temperature on fungal community and its consequences for wood microbial respiration are not well understood. Here, we examined how nitrogen and phosphorus additions (field experiment) and warming (laboratory experiment) together influence fungal composition and microbial respiration from decomposing wood of angiosperms and gymnosperms in a subtropical forest. Nutrient additions significantly increased wood microbial respiration via fungal composition, but effects varied with nutrient types and taxonomic groups. Specifically, phosphorus addition significantly increased wood microbial respiration (65%) through decreased acid phosphatase activity and increased abundance of fast‐decaying fungi (e.g., white rot), while nitrogen addition marginally increased it (30%). Phosphorus addition caused a greater increase in microbial respiration in gymnosperms than in angiosperms (83.3% vs. 46.9%), which was associated with an increase in Basidiomycota:Ascomycota operational taxonomic unit abundance in gymnosperms but a decrease in angiosperms. The temperature dependencies of microbial respiration were remarkably constant across nutrient levels, consistent with metabolic scaling theory hypotheses. This is because there was no significant interaction between temperature and wood phosphorus availability or fungal composition, or the interaction among the three factors. Our results highlight the key role of tree identity in regulating nutrient response of wood microbial respiration through controlling fungal composition. Given that the range of angiosperm species may expand under climate warming and forest management, our data suggest that expansion will decrease nutrient effects on forest carbon cycling in forests previously dominated by gymnosperm species.
Challenges in bermudagrass production in the southeastern USA
Authors: Baxter Lisa L. , Anderson William F. , Gates Roger N. , Rios Esteban F. , Burt Justin C. 
Published: June 2024

AbstractBermudagrass (Cynodon dactylon (L.) Pers.) is one of the primary perennial forages in the southeastern USA. Newer hybrid cultivars have superior production and nutritive value compared to common ecotypes. However, there are many challenges facing bermudagrass production in the region. First, the bermudagrass stem maggot (BSM; Atherigona reversura Villeneuve) has severely damaged bermudagrass throughout the region. Strategically timed pyrethroid applications significantly reduce adult BSM populations, but efforts are needed to develop integrated pest management plans. Second, an increasing number of producers are noting challenges with green‐up following winter dormancy. This may be attributed to disease, unbalanced soil fertility, and weed pressure. Perhaps one of the most limiting factors for continued production is the deficit of sprigs and trained personnel to sprig hybrid bermudagrasses. This research is critically important as the need for cold‐tolerant bermudagrass is increasing as tall fescue (Lolium arundinaceum (Schreb.) S. J. Darbyshire) is declining due to changes in temperature and precipitation throughout the northern parts of the region. Plant breeders are investigating hybrid bermudagrass at latitudes >35° with respect to freeze or cold tolerance. Despite the many challenges facing hybrid bermudagrass in the southeastern USA, researchers are working to ensure its persistence, productivity, and availability for the future.