bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Mechanistic Insights into Copper‐Catalyzed Sonogashira—Hagihara‐Type Cross‐Coupling Reactions: Sub‐Mol% Catalyst Loadings and Ligand Effects.
Authors: Zou Liang‐Hua , Johansson Adam Johannes , Zuidema Erik , Bolm Carsten 
Published: October 2013

AbstractAn efficient catalytic system for the title reaction is developed.
ChemInform Abstract: Regio‐ and Diastereoselective Synthesis of Functionalized Hydroxyhexahydrocyclopenta[b]furancarboxylates by Oxidative Radical Cyclization of Cyclic β‐Keto Esters with Alkenes.
Authors: Yoshida Masahiro , Takai Hironobu , Yodakawa Shota , Shishido Kozo 
Published: October 2013

AbstractStyrenes, enynes, and allenes are found to be suitable substrates for the radical cyclization with keto ester (II) providing generally mixtures of two diastereomeric hemiacetals.
ChemInform Abstract: Direct Asymmetric Vinylogous Aldol Reaction of Allyl Ketones with Isatins: Divergent Synthesis of 3‐Hydroxy‐2‐oxindole Derivatives.
Authors: Zhu Bo , Zhang Wen , Lee Richmond , Han Zhiqiang , Yang Wenguo , Tan Davin , Huang Kuo‐Wei , Jiang Zhiyong 
Published: October 2013

AbstractThe first highly enantioselective direct vinylogous aldol reaction between allyl aryl ketones and isatins is developed using a L‐valine derived bifunctional amino‐thiourea catalyst.
ChemInform Abstract: Leaving Group and Regioselectivity Switches in the Aminoalkylation Reaction of Indoles and Related Heterocycles with α‐Amido Sulfones.
Authors: Blay Gonzalo , Giron Rosa M. , Montesinos‐Magraner Marc , Pedro Jose R. 
Published: October 2013

AbstractTwo methods are presented which allow the regioselective C‐ or N‐aminoalkylation of indoles, pyrroles or azaindoles.
ChemInform Abstract: A Highly Enantioselective Catalytic Mannich Reaction of Indolenines with Ketones.
Authors: Cheng Dao‐Juan , Tian Shi‐Kai 
Published: October 2013

AbstractThe L‐proline catalyzed Mannich reaction of polysubstituted indolenines with ketones proceeds in a highly regio‐ and enantioselective manner to give the corresponding 2‐acylmethyl derivatives.
ChemInform Abstract: Pd‐Mediated Construction of a Cyclopentane Ring Fused with Indoles.
Authors: Prasad Bagineni , Sreenivas B. Yogi , Krishna G. Rama , Kapavarapu Ravikumar , Pal Manojit 
Published: October 2013

AbstractThe Pd‐mediated cascade reaction of iodide (III) involves an intramolecular Heck coupling, a cleavage of two C—N bonds, and formation of several C—C bonds to afford fused cyclopentane indoles (IV).
ChemInform Abstract: Beyond Classical Reactivity Patterns: Shifting from 1,4‐ to 1,6‐Additions in Regio‐ and Enantioselective Organocatalyzed Vinylogous Reactions of Olefinic Lactones with Enals and 2,4‐Dienals.
Authors: Dell'Amico Luca , Albrecht Lukasz , Naicker Tricia , Poulsen Pernille H. , Joergensen Karl Anker 
Published: October 2013

AbstractThe new concept presented here is developed for the unprecedented intermolecular enantioselective organocatalyzed vinylogous 1,6‐addition to linear 2,4‐dienals.
ChemInform Abstract: Propargyl Anthranilate Derivatives and Their Application in the Synthesis of Rings Containing 1,2,3‐Triazolo Motifs.
Authors: Hradilova Ludmila , Grepl Martin , Hlavac Jan , Lycka Antonin , Hradil Pavel 
Published: October 2013

AbstractOptimized processes for the preparation of propargyl anthranilates (III) and the intramolecular cyclization of their azide derivatives are described and the cytostatic properties of the newly synthesized compounds are evaluated (no appreciable activity found).
ChemInform Abstract: A Simple and General Approach for the Synthesis of Highly Functionalized 6‐Oxo‐1,6‐dihydropyridines.
Authors: Kumar Sukeerthi , Thakur Rajni R. , Margal Sanjay R. , Thomas Abraham 
Published: October 2013

AbstractOptimized conditions are developed for the selective synthesis of 6‐oxo‐1,6‐dihydropyridines (III) from 2‐cyano‐3,3‐bis(methylthio)arylamides (I) and β‐diketoester (II).
ChemInform Abstract: A Facile and Efficient Solid Supported, One‐Pot Synthesis of Functionalized Piperidine Derivatives Catalyzed by Amberlite IRA400‐Cl Resin/I2/KI via Multicomponent Reaction.
Authors: Harichandran Gurusamy , Amalraj Savarimuthu David , Shanmugam Ponnusamy 
Published: October 2013

AbstractThe formation of the piperidine derivatives is assumed to proceed via reaction of the aldehyde with a β‐ketoester‐derived enolate anion to form an α‐substituted β‐ketoester intermediate.
ChemInform Abstract: Tetraalkynylated and Tetraalkenylated Benzenes and Pyridines: Synthesis and Photophysical Properties.
Authors: Ehlers Peter , Hakobyan Ani , Neubauer Antje , Lochbrunner Stefan , Langer Peter 
Published: October 2013

AbstractConvenient high yielding procedures are developed for the conversion of 2,3,5,6‐tetrachloropyridine and 1,2,4,5‐tetrachlorobenzene to tetraalkynyl and tetraalkenyl derivatives by four‐fold Sonogashira or Heck reaction.
ChemInform Abstract: Extending the Scope of the Aza‐Fischer Synthesis of 4‐ and 6‐Azaindoles.
Authors: Thomae David , Jeanty Matthieu , Coste Jerome , Guillaumet Gerald , Suzenet Franck 
Published: October 2013

AbstractThe cascade reaction of the Fischer synthesis can be efficiently applied to the formation of 4‐ and 6‐azaindoles using microwave irradiation.
ChemInform Abstract: Synthesis of Pyrido[1,2‐a]benzimidazoles by Photo‐Stimulated C—N Bond Formation via SRN1 Reactions.
Authors: Barolo Silvia M. , Wang You , Rossi Roberto A. , Cuny Gregory D. 
Published: October 2013

AbstractOptimized reaction conditions are established for an intramolecular SRN1 type cyclization of 2‐(2‐haloarylamino)pyridines (I) to give pyrido[1,2‐a]benzimidazoles in good yield.
ChemInform Abstract: Regioselective Metalations of Pyrimidines and Pyrazines by Using Frustrated Lewis Pairs of BF3·OEt2 and Hindered Magnesium— and Zinc—Amide Bases.
Authors: Groll Klaus , Manolikakes Sophia M. , du Jourdin Xavier Mollat , Jaric Milica , Bredihhin Aleksei , Karaghiosoff Konstantin , Carell Thomas , Knochel Paul 
Published: October 2013

AbstractThis paper describes the regioselective electrophilic substitution of different ring positions in pyrimidine, pyrazine, and thienopyrimidine derivatives.
ChemInform Abstract: Synthesis of Substituted Diazino[c]quinolin‐5(6H)‐ones, Diazino[c]isoquinolin‐6(5H)‐ones, Diazino[c]naphthyridin‐6(5H)‐ones and Diazino[c]naphthyridin‐5(6H)‐ones
Authors: Fresneau Nathalie , Cailly Thomas , Fabis Frederic , Bouillon Jean‐Philippe 
Published: October 2013

Abstractvia one‐pot cross‐coupling/cyclization or two‐step cross‐coupling/KOH‐mediated anionic ring closure reactions
ChemInform Abstract: Synthesis of 3‐Hetaryl‐1,5,3‐dithiazepanes and 3‐Hetaryl‐1,5,3‐dithiazocanes in the Presence of Catalysts Based on Transition Metals.
Authors: Makhmudiyarova N. N. , Prokof'ev K. I. , Mudarisova L. V. , Ibragimov A. G. , Dzhemilev U. M. 
Published: October 2013

AbstractAdditionally 3‐hetaryl‐1,5,3‐dithiazepanes are synthesized in comparable yields to 3‐hetaryl‐1,5,3‐dithiazocanes (IV).
ChemInform Abstract: Efficient Synthesis of 3‐Aryl(hetaryl)‐1,5‐3‐dioxazepanes Involving Catalysts Containing Sm and Co.
Authors: Makhmudiyarova N. N. , Prokof'ev K. I. , Mudarisova L. V. , Ibragimov A. G. , Dzhemilev U. M. 
Published: October 2013

AbstractThe synthesis of compounds (III) from dioxazepane (I) and aryl amine (II) is also possible with CoCl2 as catalyst.
ChemInform Abstract: Removal of an Anionic Dye, Orange G from Aqueous Solutions by Adsorption on Unmodified Sheesham (Dalbergia sisso) Saw Dust.
Authors: Banerjee Sushmita , Nigam Vriddhi , Gautam Ravindra Kumar , Halder Sudeep , Chattopadhyaya M. C. 
Published: October 2013

AbstractKinetic and equilibrium studies show that unmodified, nontoxic, and readily available sheesham saw dust can be efficiently used to remove toxic dye Orange G from aqueous solutions simply by adsorption.
ChemInform Abstract: Sesterterpene Glycinyl‐Lactams: A New Class of Glycine Receptor Modulator from Australian Marine Sponges of the Genus Psammocinia.
Authors: Capon Robert J. , et al. et al. 
Published: October 2013

AbstractThe rare marine sesterterpenes (‐)‐ircinianin (Ia) and (‐)‐ircinianin sulfate (Ib), along with the new biosynthetically related metabolites (‐)‐ircinianin lactam A (Ic), (‐)‐ircinianin lactam A sulfate (Id), (‐)‐oxoircinianin (IIa), (‐)‐oxoircinianin lactam A (IIb) and (‐)‐ircinianin lactone A (Ie) are presented.
ChemInform Abstract: Total Syntheses of Eudistomins Y1—Y7 by an Efficient One‐Pot Process of Tandem Benzylic Oxidation and Aromatization of 1‐Benzyl‐3,4‐dihydro‐β‐carbolines.
Authors: Trieu Tien Ha , Dong Jing , Zhang Qiang , Zheng Bo , Meng Tian‐Zhuo , Lu Xia , Shi Xiao‐Xin 
Published: October 2013

AbstractThe first total synthesis of eudistomin Y7 (Ia) and total syntheses of eudistomins Y1‐Y6 (Ib‐g) are described.
ChemInform Abstract: Structure and Biosynthesis of Scabichelin, a Novel Tris‐Hydroxamate Siderophore Produced by the Plant Pathogen Streptomyces scabies 87.22.
Authors: Kodani Shinya , Bicz Joanna , Song Lijiang , Deeth Robert J. , Ohnishi‐Kameyama Mayumi , Yoshida Mitsuru , Ochi Kozo , Challis Gregory L. 
Published: October 2013

Abstractisolation and structure elucidation of scabichelin (Ia) and turgichelin (Ib)
ChemInform Abstract: Synthesis and Radical Scavenging Activities of Resveratrol Analogues.
Authors: Csuk Rene , Albert Sabrina , Siewert Bianka 
Published: October 2013

Abstract56 Resveratrol analogs of type (I) are prepared by the Pd‐catalyzed Mizoroki—Heck reaction of styrols with brominated benzenes in triethanolamine.
Discovery of MK‐8742: An HCV NS5A Inhibitor with Broad Genotype Activity
Authors: Coburn Craig A. , Meinke Peter T. , Chang Wei , Fandozzi Christine M. , Graham Donald J. , Hu Bin , Huang Qian , Kargman Stacia , Kozlowski Joseph , Liu Rong , McCauley John A. , Nomeir Amin A. , Soll Richard M. , Vacca Joseph P. , Wang Dahai , Wu Hao , Zhong Bin , Olsen David B. , Ludmerer Steven W. 
Published: October 2013

AbstractThe NS5A protein plays a critical role in the replication of HCV and has been the focus of numerous research efforts over the past few years. NS5A inhibitors have shown impressive in vitro potency profiles in HCV replicon assays, making them attractive components for inclusion in all oral combination regimens. Early work in the NS5A arena led to the discovery of our first clinical candidate, MK‐4882 [2‐((S)‐pyrrolidin‐2‐yl)‐5‐(2‐(4‐(5‐((S)‐pyrrolidin‐2‐yl)‐1H‐imidazol‐2‐yl)phenyl)benzofuran‐5‐yl)‐1H‐imidazole]. While preclinical proof‐of‐concept studies in HCV‐infected chimpanzees harboring chronic genotype 1 infections resulted in significant decreases in viral load after both single‐ and multiple‐dose treatments, viral breakthrough proved to be a concern, thus necessitating the development of compounds with increased potency against a number of genotypes and NS5A resistance mutations. Modification of the MK‐4882 core scaffold by introduction of a cyclic constraint afforded a series of tetracyclic inhibitors, which showed improved virologic profiles. Herein we describe the research efforts that led to the discovery of MK‐8742, a tetracyclic indole‐based NS5A inhibitor, which is currently in phase 2b clinical trials as part of an all‐oral, interferon‐free regimen for the treatment of HCV infection.
A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites
Authors: Quinten Chantal , Martinelli Francesca , Coens Corneel , Sprangers Mirjam A. G. , Ringash Jolie , Gotay Carolyn , Bjordal Kristin , Greimel Eva , Reeve Bryce B. , Maringwa John , Ediebah Divine E. , Zikos Efstathios , King Madeleine T. , Osoba David , Taphoorn Martin J. , Flechtner Henning , Schmucker‐Von Koch Joseph , Weis Joachim , Bottomley Andrew ,   on behalf of Patient Reported Outcomes and Behavioral Evidence (PROBE) and the European Organization for Research and Treatment of Cancer (EORTC) Clinical Groups
Published: October 2013

BACKGROUNDThe objective of this study was to examine the prognostic value of baseline health‐related quality of life (HRQOL) for survival with regard to different cancer sites using 1 standardized and validated patient self‐assessment tool.METHODSIn total, 11 different cancer sites pooled from 30 European Organization for Research and Treatment of Cancer (EORTC) randomized controlled trials were selected for this study. For each cancer site, univariate and multivariate Cox proportional hazards modeling was used to assess the prognostic value (P < .05) of 15 HRQOL parameters using the EORTC Core Quality of Life Questionnaire (QLQ‐C30). Models were adjusted for age, sex, and World Health Organization performance status and were stratified by distant metastasis.RESULTSIn total, 7417 patients completed the EORTC QLQ‐C30 before randomization. In brain cancer, cognitive functioning was predictive for survival; in breast cancer, physical functioning, emotional functioning, global health status, and nausea and vomiting were predictive for survival; in colorectal cancer, physical functioning, nausea and vomiting, pain, and appetite loss were predictive for survival; in esophageal cancer, physical functioning and social functioning were predictive for survival; in head and neck cancer, emotional functioning, nausea and vomiting, and dyspnea were predictive for survival; in lung cancer, physical functioning and pain were predictive for survival; in melanoma, physical functioning was predictive for survival; in ovarian cancer, nausea and vomiting were predictive for survival; in pancreatic cancer, global health status was predictive for survival; in prostate cancer, role functioning and appetite loss were predictive for survival; and, in testis cancer, role functioning was predictive for survival.CONCLUSIONSThe current results demonstrated that, for each cancer site, at least 1 HRQOL domain provided prognostic information that was additive over and above clinical and sociodemographic variables.Cancer2014;120:302–311. ©2013 American Cancer Society.
Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic‐hypothalamic area in zebrafish larvae
Authors: Herget Ulrich , Wolf Andrea , Wullimann Mario F. , Ryu Soojin 
Published: October 2013

ABSTRACTThe paraventricular nucleus (PVN) in mammals is the main hypothalamic nucleus controlling hormone release in the pituitary and plays pivotal roles in homeostasis. While the location of a PVN‐homologous region has been described in adult fish as the neurosecretory preoptic area (NPO), this region has not been clearly defined in larval zebrafish due to the difficulty in defining cytoarchitectonic nuclear boundaries in the larval brain. Here we identify the precise location of the larval zebrafish NPO using conserved transcription factor and neuropeptide gene expressions. Our results identify the dorsal half of the preoptic‐hypothalamic orthopedia a (otpa) domain as the larval NPO and the homologous region to the mammalian PVN. Further, by reconstructing the locations of cells producing zebrafish neuropeptides found in the mammalian PVN (CCK, CRH, ENK, NTS, SS, VIP, OXT, AVP), we provide the first 3D arrangement map of NPO neuropeptides in the larval zebrafish brain. Our results show striking conservation of transcription factor expression (otp, arx, dlx5a, isl1) in and around the NPO/PVN together with neuropeptide expression within it. Finally, we describe the exact anatomical location of cells producing Oxt and Avp in the adult zebrafish. Thus, our results identify the definitive borders and extent of the PVN homologous region in larval zebrafish and serve as an important basis for cross‐species comparisons of PVN/NPO structure and function. J. Comp. Neurol. 522:1542–1564, 2014. © 2013 Wiley Periodicals, Inc.
A comparative study of parallel software SURF implementations
Authors: Hidalgo‐Paniagua Alejandro , Vega‐Rodríguez Miguel A. , Pavón Nieves , Ferruz Joaquín 
Published: October 2013

SUMMARYNowadays, it is common to find problems that require recognizing objects in an image, tracking them along time, or recognizing a complete real‐world scene. One of the most known and used algorithms to solve these problems is the Speeded Up Robust Features (SURF) algorithm. SURF is a fast and robust local, scale and rotation invariant, features detector. This means that it can be used for detecting and describing a set of points of interest (keypoints) from an image. Because of the importance of this algorithm and the rise of the parallelism‐based technologies, in the last years, diverse parallel implementations of SURF have been proposed. These parallel implementations are based on very different techniques: Compute Unified Device Architecture, OpenMp, OpenCL, and so on. In conclusion, we think valuable a comparative study of all of them highlighting the advantages and disadvantages of each parallel implementation. To our best knowledge, this article is the first attempt to do this comparative study. In order to make this study, we have used the standard metrics and image collection in this field, as well as other important metrics in parallelism as speedup and efficiency. Copyright © 2013 John Wiley & Sons, Ltd.
Comparative phylogeography of two sympatric beeches in subtropical China: Species‐specific geographic mosaic of lineages
Authors: Zhang Zhi‐Yong , Wu Rong , Wang Qun , Zhang Zhi‐Rong , López‐Pujol Jordi , Fan Deng‐Mei , Li De‐Zhu 
Published: October 2013

AbstractIn subtropical China, large‐scale phylogeographic comparisons among multiple sympatric plants with similar ecological preferences are scarce, making generalizations about common response to historical events necessarily tentative. A phylogeographic comparison of two sympatric Chinese beeches (Fagus lucida and F. longipetiolata, 21 and 28 populations, respectively) was conducted to test whether they have responded to historical events in a concerted fashion and to determine whether their phylogeographic structure is exclusively due to Quaternary events or it is also associated with pre‐Quaternary events. Twenty‐three haplotypes were recovered for F. lucida and F. longipetiolata (14 each one and five shared). Both species exhibited a species‐specific mosaic distribution of haplotypes, with many of them being range‐restricted and even private to populations. The two beeches had comparable total haplotype diversity but F. lucida had much higher within‐population diversity than F. longipetiolata. Molecular dating showed that the time to most recent common ancestor of all haplotypes was 6.36 Ma, with most haplotypes differentiating during the Quaternary. [Correction added on 14 October 2013, after first online publication: the time
unit has been corrected to ‘6.36’.] Our results support a late Miocene origin and southwards colonization of Chinese beeches when the aridity in Central Asia intensified and the monsoon climate began to dominate the East Asia. During the Quaternary, long‐term isolation in subtropical mountains of China coupled with limited gene flow would have lead to the current species‐specific mosaic distribution of lineages.
3D Organization of Dysprosium Cubanes
Authors: Yi Xiaohui , Bernot Kevin , Calvez Guillaume , Daiguebonne Carole , Guillou Olivier 
Published: October 2013

AbstractThe reaction of isonicotinic acid N‐oxide and Dy(NO)3·6H2O under aerobic conditions leads to the formation of a porous lanthanide, a cubane‐based 3D edifice of the formula [Dy4(μ3‐OH)3(μ3‐O)(NOPyCOO)6(OH)(H2O)3·(DMF)3(H2O)12]∞ (NOPyCOO = pyridine‐4‐carboxylate N‐oxide). Crystal structure investigations show that the [Dy4(μ3‐OH)3(μ3‐O)] cubane cores are interconnected by organic ligands to form an extended porous structure. Thermogravimetric analyses and temperature‐dependent X‐ray diffraction analyses evidence that the compound is stable upon dehydration/desolvatation up to 200 °C. Calculations for the N2 kinetic radius afford a void volume of 3603 Å3 per unit cell (33.8 %) and a potential porosity of 1400 m2 g–1. The large pores can potentially host molecules with a projected surface area as large as 20 Å2 into a large pore volume (600 Å3). Moreover, the onset of a slow magnetic relaxation has been observed and rationalized by a comparison with closely related 0D and 2D compounds.
Binuclear Cage‐Like Copper(II) Silsesquioxane (“Cooling Tower”) – Its High Catalytic Activity in the Oxidation of Benzene and Alcohols
Authors: Bilyachenko Alexey N. , Dronova Marina S. , Yalymov Alexey I. , Korlyukov Alexander A. , Shul'pina Lidia S. , Arkhipov Dmitry E. , Shubina Elena S. , Levitsky Mikhail M. , Kirilin Alexey D. , Shul'pin Georgiy B. 
Published: October 2013

AbstractInvited for the cover of this issue is the group of Alexey Bilyachenko at the Nesmeyanov Institute of Organoelement Compounds. The cover image illustrates a symbolic process of benzene/alcohol oxidation catalysis by the binuclear cage‐like copper(II) silsesquioxane with an unprecedented structure (“Cooling Tower”).
Enantioselective Organocatalytic Synthesis of Sulfur‐Containing Spirocyclic Compounds
Authors: Géant Pierre‐Yves , Urban Michal , Remeš Marek , Císařová Ivana , Veselý Jan 
Published: October 2013

AbstractTwo different enantioselective organocatalytic cascade reactions to form new sulfur‐containing spirocyclic scaffolds are described. In the first approach, benzothiophen‐2‐one and enals react in the presence of a secondary amine catalyst through a Michael/Michael/Aldol sequence to afford the final spiro‐cyclohexene carbaldehydes in good yields (up to 68 %) and with excellent selectivities [20:1 diastereomeric ratio (dr), up to 99 % ee]. In the second approach, the double Michael addition of benzothiophen‐2‐one to aromatic dienones with primary amine catalysis produces the corresponding spiro‐cyclohexanones in good yields (up to 76 %) and with moderate‐to‐high selectivities (up to 12:1 dr, up to 90 % ee). Moreover, the use of N‐phenylrhodanine as the bis‐nucleophile for these reactions also allowed the formation of the corresponding spirocyclic adducts.
Zwitterionic 1,3‐Shift Intermediates in the Interconversions of (Thio)carbamoyl Isocyanates and Carbamoyl Iso(thio)cyanates, R2N–CX–NCO ⇌ R2N–CO–NCX, and in Carbamoylketenes R2N–CO–CH=C=O
Authors: Koch Rainer , Wentrup Curt 
Published: October 2013

AbstractCyclic zwitterionic intermediates 3 have been located as reactive intermediates in the thermal 1,3‐shifts of dimethylamino and N‐ piperidinyl groups in carbamoyl isocyanates, carbamoyl isothiocyanates and carbamoylketenes at the B3LYP, M06‐2X and MP2 computational levels of theory. The zwitterion formed in the course of the ketene ⇌ ketene rearrangement shows the highest stabilization (by about 3–5 kcal/mol). The interconversions of carbamoyl isocyanates and isothiocyanates should occur readily at or near room temperature with activation barriers in the range 23–30 kcal/mol, and the ketene ⇌ ketene interconversion is expected well below room temperature with an activation barrier of ca. 10 kcal/mol.
Synthesis of Bicyclic Thiazolidinethiones and Oxazolidinones by Water‐Mediated Multicomponent Reactions (MCR) and Ring‐Closing Metathesis (RCM)
Authors: Stalling Timo , Saak Wolfgang , Martens Jürgen 
Published: October 2013

AbstractStarting with the development of new multicomponent reactions (MCR) in water, hydroxy thiazolidinethiones and oxazolidinones were prepared efficiently in a one‐pot procedure. The reaction was carried out under mild conditions, consistent with the principles of “green chemistry”. These precursors were converted into different dienes containing terminal C–C double bonds by modifying the hydroxy group in one‐ or two‐step sequences. A final ring‐closing metathesis (RCM) reaction led to various classes of unsaturated bicycles.