bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
Authors: Hu Liang , Li Lina , Li Angcheng , Tong Jianyong 
Published: June 2024

Abstract

Background
Renal cell carcinoma (RCC) with TFE3 gene fusion caused by Xp11.2 translocations is a rare RCC subtype. This tumor is typically seen in children, comprising 20‒40% of overall RCC cases compared to 1‒1.6% observed in adults. Xp11.2 RCC is associated with a poor prognosis due to both the progression of local lesions and early distant and lymphatic metastasis.

Case presentation
A case of RCC with Xp11.2 RCC translocations and TFE3 gene fusion was found in a pediatric patient, illustrating the catastrophic effects of ignoring the condition. The tumor developed from a local lesion to lymph metastasis (3.2–12 cm) within 4 years. Despite ongoing controversy, surgical resection remains the most common and productive approach. In this patient, renal retroperitoneal lymph node dissection and radical nephrectomy of the left kidney were performed via laparoscopic surgery. The RCC-associated Xp11.2 translocation/TFE3 gene fusions were identified by postoperative pathology. Microscopic analysis showed the presence of intravascular cancer thrombus, renal sinus invasion, and cancer necrosis. The pathological stages were confirmed as PT3aN1M0 with a negative margin. Follow-up at 5 months showed that the patient recovered without the use of any adjuvant treatments.

Conclusion
Our study highlights the natural course, diagnosis, and treatment of RCC-associated Xp11.2 translocation/TFE3 gene fusions, especially the necessity of early surgery. This case may be a helpful reference for urologists in the treatment of similar cases. It also serves as a precautionary signal for patients who neglect the renal neoplasm.
Diversifying the educator workforce: promising aspects of teacher preparation programs
Authors: LaPorte-Grimes Laurel A. , Parham Marcquis T. 
Published: June 2024

Abstract
The present study contributes to the body of work addressing the need for diversity in the educator workforce. The study examines six grant-funded projects designed to increase the diversity of teacher candidates, support these candidates through licensure, and ultimately increase the diversity of the teacher workforce in Ohio. Data was gathered from Principal Investigators and other project members via mid-year and end-of-year interviews (N = 12) and analyzed using qualitative coding methods. The analysis surfaced common themes among program features, program implementation, and challenges programs encountered. The findings suggest that effective programs to diversify the educator workforce could benefit from program development that makes intentional use of several key strategies: (1) collaborative processes and relationships; (2) programmatic and individual student support; (3) targeted, personal approaches to recruitment; (4) intentional planning for financial sustainability (including the use of more than one funding stream); and (5) the creation of specific pathways from high school to career. This study further identified both internal and external systemic challenges programs encountered and highlighted effective methods for resolving issues where possible, while also identifying challenges that remained intractable.
Numerical and experimental investigation of the effect of heat input on weld bead geometry and stresses in laser welding
Authors: Turan Mehmet K. , Yuce Celalettin , Karpat Fatih 
Published: June 2024

Abstract
Nowadays, laser welding is a powerful joining method. Thanks to the advantages it has, its usage area is increasing day by day. However, getting the desired result from the laser welding process is possible with the proper welding parameter selections. Otherwise, many problems may be encountered, including significantly incomplete penetration. For this reason, parameter selection has been discussed in many studies in the literature. At this point, validated numerical simulation models are precious. Since these models reduce experiment costs and save time. Especially numerical simulation of the structural steel, which is the one of most used materials, is crucial. In this study, the effects of laser power (LP) and welding speed (WS), which are among the vital parameters of laser welding, on weld width and stress were investigated numerically and statistically. Structural steel was selected as the material, and the Taguchi method was carried out for the simulation case study design. Simufact Welding software was used for simulation studies, and simulations were carried out thermomechanical. Thus, more realistic results were obtained via the thermomechanical method. One of the simulation results was verified through an experimental study. The results were evaluated with signal-to-noise (S/N) ratio and a statistical analysis of variance (ANOVA), and as a result of the study, it was seen that the welding speed was a more effective parameter, the optimal parameter combination was found to be 3500 W for laser power and 40 mm/s for welding speed to get maximum weld width and minimum equivalent stress. In addition, it was observed that correctly created simulation studies may provide very close results to experimental studies.
Exploratory outcomes of the use of insulin degludec in the real world: data from the Association of British Clinical Diabetologists nationwide degludec audit
Authors: Colosimo Santo , Ruan Yue , Lumb Alistair , Rea Rustam , McDonald Paula , Bain Stephen , Abraham Ralph , Gallen Ian , Ryder Robert 
Published: June 2024

Insulin degludec is a long-acting basal insulin analog that is used as a single daily injection in people living with type 2 diabetes (T2DM) or in combination with rapid-acting analogs in basal-bolus regimens in people living with T2DM or type 1 diabetes (T1DM). Registration studies showed benefits of reduction of hypoglycaemia rate and severity compared to previously available long-acting insulins.
The Association of British Clinical Diabetologists nationwide clinical audit of insulin degludec is a real-world data program which includes a secondary care prospective data collection and a primary care retrospective data collection. Data were used to investigate the effects of degludec initiation in people living with T1DM or T2DM on hypoglycaemia rate and severity, change in haemoglobin A1c (HbA1c) and weight change.
From the secondary care prospective and the primary care retrospective data 432 (of whom T1DM=273) and 3,513 (of whom T1DM=2,040) patients, respectively, were included in the analysis. HbA1c change was non-significant in people with T1DM and T2DM who were switched to insulin degludec due to hypoglycaemia in the secondary care cohort. A significant reduction of 3 and 10 mmol/mol was observed in people with T1DM and T2DM, respectively, when the switch to degludec was prompted by reasons other than hypoglycaemia, and in people with T1DM this was also associated with a 2.5 kg weight gain. There was a clinically significant reduction in minor, severe and nocturnal hypoglycaemia in 62%, 45% and 54% of T1DM and in minor hypoglycaemia in 44% of T2DM in the prospective cohort.
Insulin degludec reduced HbA1c in people with diabetes who were started for non-hypoglycaemia reasons and in people in the retrospective cohort. The extent of reduction in HbA1c was similar in both cohorts, even after stratification for T1DM and T2DM. Overall, insulin degludec resulted in lower HbA1c and modest weight gain in people starting for non- hypoglycaemia reasons and lower hypoglycaemia without any change in HbA1c or weight in people switching due to hypoglycaemia.
The potential of protective glass from smartphones as an emergency personal dosimeter for members of the general public in radiological accidents
Authors: SHOLOM SERGEY , McKeever Steve 
Published: June 2024

The potential of the back protective glass from modern smartphones as a possible material for an emergency triage, OSL dosimeter was evaluated. Strong OSL signals were observed in samples of glass from phones of different models and brands after irradiation. Some important parameters of these signals were analyzed, namely the OSL decay curve shape, the dependence on dose, and the stability (fading) with time after exposure. Analysis of the shape suggested that the main mechanism of the OSL production is optically assisted tunneling. The dose-response characteristics demonstrated linearity in the tested dose range (0-2.7 Gy) provided that fading was accounted for during calibration irradiation. The fading after irradiation was described by a universal, two-component function with a primary component due to tunneling and a secondary, thermal component. Dose reconstruction tests were carried out for in-service phones exposed to known doses and then kept in normal usage (phone calls, texts, web surfing, etc.) as well as for out-of-service phones irradiated to blind (unknown) doses. Dose reconstruction was conducted using a custom-made OSL reader without dismantling any part of the phone. OSL-reconstructed, fading-corrected doses were within 25% (worse case) of the corresponding nominal values. It was concluded that the back protective glass can be used as an OSL emergency triage dosimeter (if protected from ambient light by a phone case).
Development and calibration of a portable detection device for in vivo measurement of high-energy photon emitters incorporated by humans
Authors: Soares Alexandre Barbosa , Arbach Mayara Nascimento , De Lucena Éder Augusto , Dantas Ana Letícia Almeida , Dantas Bernardo Maranhão 
Published: June 2024

This work presents the evaluation of the applicability and sensitivity of a portable detection device specially designed for in vivo measurement of high-energy photon emitters in the human body. The calibration was performed at the In-Vivo Monitoring Laboratory of the IRD. The equipment consists of a lead-collimated NaI (Tl) 3”x3” scintillation detector assembled on a tripod. The detector and its compact associated electronics are connected via USB cable to a portable PC. Spectrum acquisition and analysis is controlled by specific commercially available software. The calibration was performed using a standard liquid source of 152Eu contained in 3 L polyethylene bottles. The evaluation of the system is based on the estimation of the minimum committed effective doses associated to the minimum detectable activities, calculated using current biokinetic and dosimetric models available in the literature. The dose detection limits for selected radionuclides of interest in an emergency scenario have shown to be far below 1 mSv allowing the system to be useful in accident situations.
Analysis of the external doses received by workers involved in the mitigation of the Goiania radiological accident
Authors: Mauricio Claudia Lucia de Pinho 
Published: June 2024

In 1987, after identification that a stolen head of a Cs-137 radiotherapy irradiator was violated, it starts, in Goiania, the screening of the involved persons, the decontamination and the collection of the radioactive waste. The contaminated areas were isolated and the professionals who worked within these areas received individual film monitors and TLD rings, provided by the Instituto de Radioproteção e Dosimetria of the Comissão Nacional de Energia Nuclear (IRD/CNEN), to evaluate their external dose. The aim of this paper is to present a statistical analysis of the external occupational doses received by this intervention staff. The used data were extracted from the Goiania accident database, maintained by IRD/CNEN. A total of 1091 workers were monitored, some for only a few days and others for almost one year. All the total external occupational doses, received during these works, including the management of the radioactive waste, were lower than the individual annual dose limit of 50 mSv for practices. Only one dose exceeded the value of 20 mSv. Their estimated mean effective doses were about 1.0 mSv, which is the annual dose limit for public exposure. About 80% of the doses were lower than this value. The measured extremity doses were even lower than the measured whole body doses values.
Teste de tipo de um sistema de dosimetria TL para monitoração individual de fótons em Hp(10)
Authors: Ferreira Max da Silva , Da Silva Everton Rodrigues , Maurício Cláudia Lúcia de Pinho 
Published: June 2024

Although regulated, the use of HP(10) to estimate the effective dose of photons has not yet been implemented in Brazil. The operational quantity used in the country, temporarily, is the photon dose equivalent (Hx). For the external monitoring of individuals exposed to photons, the IRD uses an automatic TL dosimetry system with individual MTS-N monitors from the RADOS manufacturer, which contains LiF: Mg, Ti TLDs. The objective of this work was to characterize this system for the evaluation of the operational quantity HP(10). The measuring range is 0.2 mSv to 2 Sv, for photon energies from 20 keV to 1250 keV. The type test was done through performance tests for the following characteristics: homogeneity of the monitors, system reproducibility, linearity, temperature and humidity effect, energy and angular dependence, and fading. The acceptance requirements were taken from IEC 62387 standard and IRD-RT 002.01/95 technical regulation. The results show that all requirements have been met, except for the N-25 quality, at the angle of 60°.
PULLER®: ferramenta educativa para auxílio ao aprendizado sobre proteção radiológica
Authors: PEREIRA JAQUELINE SANT' ANNA LAUREANO , PEREIRA DANIEL LAUREANO , PELEGRINELI SAMUEL QUEIROZ , RÊGO JOSONILTON COSTA MORAES , OLIVEIRA LUCIANO SANTA RITA 
Published: June 2024

RESUMOO uso de smartphones em âmbito educacional, embora restrito, seu potencial é evidente no tocante a interação e mobilidade. Este estudo apresenta o desenvolvimento do aplicativo PULLER® para dispositivos móveis no contexto da educação em proteção radiológica. É um estudo de natureza quantitativa do tipo semiexperimental não randomizado, equivalente, do tipo anterior e posterior e também é uma produção tecnológica fundamentada na metodologia Design Instrucional Contextualizado, cuja a linguagem adotada é Html5, css3, JavaScript e PHP, permitindo aos estudantes autonomia do saber, de acordo com seu ritmo, tornando-os críticos e reflexivos perante as informações, transformando-as em conhecimento. A avaliação do aplicativo foi positiva, 70% dos 300 participantes atingiram a média alvo de 08 pontos. Os resultados apontaram que o uso da calculadora radiológica e as informações sobre dosimetria contribuíram com o aprendizado sem pressão de tempo ou lugar, houve diferença das médias ponderadas entre o pré e pós-teste dos alunos com o aplicativo, o que contribuiu para a melhoria do processo assistencial e educativo mediada pelo uso do aplicativo PULLER®. ABSTRACTThe use of smartphones in education, although restricted, its potential is evident in terms of interaction and mobility. This study presents the development of the PULLER® mobile application in the context of radiation protection education. It is a quantitative study of the non-randomized, semioxic experimental type, equivalent, of the anterior and posterior type, and is also a technological production based on the Methodology Contextualized Instructional Design, whose adopted language is Html5, css3, JavaScript and PHP, allowing students autonomy know, according to their rhythm, making them critical and reflective to the information, transforming them into knowledge. The evaluation of the application was positive, 70% of the 300 participants reached the target average of 08 points. The results showed that the use of the radiological calculator and the information on dosimetry contributed to the learning without pressure of time or place, there was a difference of the weighted averages between the pre and post test of the students with the application, which contributed to the improvement of the welfare process mediated through the use of the PULLER® application.
Israel, Palästina und Bilder-Fragen
Authors: Runge Evelyn 
Published: June 2024

Dieser Essay kartiert bildethische Kontroversen und Herausforderungen für individuelle Fotojournalist:innen, Fotoredakteur:innen und Mediennutzer:innen, die sich durch digitale, vernetzte Bilder während und nach dem Attentat der Hamas auf israelisches Staatsgebiet am und nach dem 7. Oktober 2023 abbilden. Während in deutschsprachigen Redaktionen Entscheidungen oft in Dichotomien des Veröffentlichens und Nicht-Veröffentlichens verharren, wendet sich die englischsprachige Fototheorie und journalistische Bildethik seit einigen Jahren hin zu komplementären Ansätzen, wie beispielsweise Newton und Dodd (Dodd, 2023; Newton, 2021). Diese werden sowohl den fotojournalistischen Produktionsbedingungen im Feld und unterschiedlichen Rollen und Selbst-Identitäten (Good & Lowe, 2020) gerechter. Zugleich entlassen sie Rezipient:innen nicht aus der eigenen ethischen Verantwortung und Bildung von ethischer Kompetenz (ethical literacy). Gerade im Umgang mit KI-generierten Bildern, die durch fotorealistische Fiktionalisierungen vorgeben, das Leiden von Menschen in Israel und Palästina illustrieren zu können, sind Redaktionen zu besonders sensiblem Umgang mit Medienökologien gefragt, wie exemplarisch die Paris Charter on AI and Journalism verdeutlicht (Reporters Without Borders, 2023a).
Assessment of nutritional status and health challenges among female garment workers: a cross-sectional study
Authors: Newaz Taslima , Dutta Arup , Rahman M. Shafiur , Hossain Moynal , Hoque M. Ahasanul , Purba Srobonti Dutta 
Published: June 2024

Background: The economic status of women is now accepted as an indicator of a society’s development in Bangladesh. Women workers like the majority in the informal sector have been exposed to rigorous work, discipline, fixed working hours, specific production norms etc. The aim of the study was to perform cross-sectional study was conducted to assess nutritional status of female garment workers in Chattogram, Bangladesh.
Methods: The study was conducted with the help of a semi-structured questionnaire to collect data from the respondents by face-to-face interview. Informed written consent was obtained from the respondents. A checklist containing height and weight (measured using measuring tape and digital weight machine respectively) of the respondents included in the questionnaire.
Results: According to the study, gastrointestinal problem was reported by 49.7% and the rest reported problem were respiratory problem (35.3%), skin problem (27.3%), urinary problem (18%), eye problem (15%). Age, marital status, number of children, family member, monthly income, job section, working hours and overtime were significantly associated with various types of health problem. Respondents were categorized into underweight (≤18.5 kg/m2), normal (18.6-24.9 kg/m2) and overweight and above (≥25.0 kg/m2) using BMI. Prevalence of underweight, normal and overweight and above were 3.3%, 61.3% and 35.3% respectively.
Conclusions: Female worker’s age, marital status, number of children, monthly income, job duration, job section and overtime showed significant association with their nutritional status (BMI). Findings of this study may play an important role to develop a policy and in commercial sector of our country to reduce health problem of the female garment workers for better productive and healthy lifestyle.
Fear of Falling and Quality of Life in Older Hemodialysis Patients in Tehran Hospitals
Authors: Dehesh Mohammad , Samady Kia Parvaneh , Rejeh Nahid , Tadrisi Seyed Davood 
Published: June 2024

Introduction: Several factors influence the quality of life (QoL) of older adults, particularly those on hemodialysis. Fear of falling and its resulting limitations are significant contributors. This study investigated the association between fear of falling and QoL in older hemodialysis patients in Tehran hospitals .

Methods: A descriptive-correlational design was used with 197 older hemodialysis patients in Tehran hospitals (2021) recruited through convenience sampling. Data were collected using a demographic questionnaire, the Falls Efficacy Scale-International , and the Leiden International Psychogeriatric Assessment of Life Functions scale to assess QoL. Spearman's rank correlation was performed using SPSS-21 software.

Results: The mean QoL score (54.68 ± 16.09) indicated a moderate level. The mean fear of falling score (35.29 ± 13.54) reflected a high level. A significant negative correlation (R = -0.63, p = 0.001) was found between fear of falling and QoL.

Conclusion: Our findings suggest that increased fear of falling is associated with a decrease in QoL among older hemodialysis patients. Further research is warranted to explore interventions aimed at managing fear of falling, preventing falls, and ultimately improving QoL in this population.
Longitudinal Health Consequences of Insomnia Symptoms among Middle-Aged and Older Adults in Thailand
Authors: Pengpid Supa , Peltzer Karl , Anantanasuwong Dararatt 
Published: June 2024

Introduction: Insomnia symptoms may impact on various health outcomes. It is unclear how insomnia symptoms impact on health in Thailand. In a longitudinal study of ageing adults in Thailand, the goal of the research was to evaluate the relationships between insomnia symptoms and 20 health indicators.

Methods: Prospective cohort data from the Health, Aging and Retirement in Thailand study, which included participants 45 years of age and older (N = 2863) from three successive waves in 2015, 2017, and 2020 were analyzed. Insomnia symptoms and health indicators were assessed by self-report. Generalized Estimating Equations analysis and logistic regression analysis were used to evaluate the longitudinal relationships between measures of insomnia symptoms and 20 health indicators.

Results: In 2020, 11.7% of people reported having insomnia symptoms, compared to 15.6% in 2015 and 14.6% in 2017. Insomnia symptoms were positively correlated with three poor mental health indicators (depressive symptoms, quality of life and self-rated mental health), eight poor physical health indicators (hypertension, self-rated physical health status, cardiovascular disease, diabetes, osteoporosis, chronic lung disease, kidney disease, and physical injury), and two lifestyle indicators (physical inactivity and meal skipping) in logistic regression models.

Conclusion: The study found that a number of indicators of physical and mental illness as well as lifestyle choices were linked to symptoms of insomnia. Improved detection and management of insomnia symptoms could lower indicators of physical and mental illness in Thailand.