bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability of Summer Rainfall in Northeast China and Its Connection with Spring Rainfall Variability in the Huang-Huai Region and Indian Ocean SST
Authors: Gao Zongting , Hu Zeng-Zhen , Zhu Jieshun , Yang Song , Zhang Rong-Hua , Xiao Ziniu , Jha Bhaskar 
Published: July 2014

AbstractIn this work, the variability of summer [June–August (JJA)] rainfall in northeast China is examined and its predictors are identified based on observational analyses and atmospheric modeling experiments. At interannual time scales, the summer rainfall anomaly in northeast China is significantly correlated with the rainfall anomaly over the Huang-Huai region (32°–38°N, 105°–120°E) in late spring (April–May). Compared with climatology, an earlier (later) rainy season in the Huang-Huai region favors a wet (dry) summer in northeast China. Also, this connection has strengthened since the late 1970s. In addition to the impact of the sea surface temperature anomaly (SSTA) in the tropical Indian Ocean, the local soil moisture anomalies caused by the rainfall anomaly in the Huang-Huai region in late spring generate summer general circulation anomalies, which contribute to the rainfall anomaly in northeast China. As a result, when compared with the SSTA, the rainfall anomaly in the Huang-Huai region in late spring can be used as another and even better predictor for the summer rainfall anomaly in northeast China.The results from atmospheric general circulation model experiments forced by observed SST confirm the diagnostic results to some extent, including the connection of the rainfall anomaly between the Huang-Huai region in April–May and northeastern China in JJA as well as the influence from SSTA in the tropical Indian Ocean. It is shown that eliminating the internal dynamical processes by using the ensemble mean intensifies the connection, implying that the connection of rainfall variation in the two different seasons/regions may be partially caused by the external forcing (e.g., SSTA in the tropical Indian Ocean).
The Impact of Best Track Discrepancies on Global Tropical Cyclone Climatologies using IBTrACS
Authors: Schreck Carl J. , Knapp Kenneth R. , Kossin James P. 
Published: July 2014

Abstract
Using the International Best Track Archive for Climate Stewardship (IBTrACS), the climatology of tropical cyclones is compared between two global best track datasets: 1) the World Meteorological Organization (WMO) subset of IBTrACS (IBTrACS-WMO) and 2) a combination of data from the National Hurricane Center and the Joint Typhoon Warning Center (NHC+JTWC). Comparing the climatologies between IBTrACS-WMO and NHC+JTWC highlights some of the heterogeneities inherent in these datasets for the period of global satellite coverage 1981–2010. The results demonstrate the sensitivity of these climatologies to the choice of best track dataset. Previous studies have examined best track heterogeneities in individual regions, usually the North Atlantic and west Pacific. This study puts those regional issues into their global context. The differences between NHC+JTWC and IBTrACS-WMO are greatest in the west Pacific, where the strongest storms are substantially weaker in IBTrACS-WMO. These disparities strongly affect the global measures of tropical cyclone activity because 30% of the world’s tropical cyclones form in the west Pacific. Because JTWC employs similar procedures throughout most of the globe, the comparisons in this study highlight differences between WMO agencies. For example, NHC+JTWC has more 96-kt (~49 m s−1) storms than IBTrACS-WMO in the west Pacific but fewer in the Australian region. This discrepancy probably points to differing operational procedures between the WMO agencies in the two regions. Without better documentation of historical analysis procedures, the only way to remedy these heterogeneities will be through systematic reanalysis.
Is There a Relationship Between Landing, Cutting, and Pivoting Tasks in Terms of the Characteristics of Dynamic Valgus?
Authors: Jones Paul A. , Herrington Lee C. , Munro Allan G. , Graham-Smith Philip 
Published: July 2014

Background: Anterior cruciate ligament (ACL) injuries are a major problem among female athletes. Screening for the risk of ACL injuries tends to focus on landing tasks, which may be limited in sports where changing direction is the main action involved in noncontact ACL injuries such as soccer. Purpose: To investigate whether there is a relationship between single-legged landing (SLL), cutting (90° cuts), and pivoting (180° turns) in terms of the characteristics of dynamic valgus. Study Design: Controlled laboratory study. Methods: Twenty female soccer players (mean ± SD: age, 21.0 ± 3.9 years; height, 1.65 ± 0.08 m; mass, 58.4 ± 6.4 kg) performed a minimum of 6 trials of SLL from a 0.3-m drop height and cutting and pivoting all on the right leg. Kinematics and kinetics were calculated from 3-dimensional motion analysis. Results: Strong correlations were found for peak knee abduction angles between tasks ( R = 0.63-0.86, P < .01), whereas only moderate correlations between SLL and cutting ( R = 0.46, P < .05), cutting and pivoting ( R = 0.56, P < .05), and SLL and pivoting ( R = 0.43, P > .05) were found between tasks for peak knee abduction moments. Conclusion: The results suggest that female athletes who exhibit poor SLL mechanics perform the same during various changing direction tasks. Clinical Relevance: The results support the use of existing screening tests that involve landing tasks to identify at-risk athletes for noncontact ACL injuries.
A National Survey of Critical Care Physicians’ Knowledge, Attitudes, and Perceptions of Antimicrobial Stewardship Programs
Authors: Steinberg Marilyn , Dresser Linda D. , Daneman Nick , Smith Orla M. , Matte Andrea , Marinoff Nicole , Bell Chaim M. , Morris Andrew M. 
Published: July 2014

Objective: Antimicrobial stewardship is a process designed to optimize antimicrobial therapy by ensuring patients get the right antimicrobials at the right dose and at the right time. Antimicrobial stewardship programs (ASPs) are increasingly being implemented in health care institutions, are required by some accreditation bodies, and have the potential for maximum impact in intensive care units (ICUs). We administered a survey to critical care physicians across Canada to better understand their knowledge, attitudes, and perceptions on the utility of ASPs in improving patient care. Design, Setting, and Patients: We distributed a Web-based survey to physicians who attend in Canadian ICUs. Respondents were identified through the membership lists of multiple critical care organizations. Content validity, utility, clarity, and test–retest reliability were evaluated prior to distribution. Survey items assessed ASP knowledge, attitudes, and experiences. Attitudes toward ASPs were assessed on a 5-point Likert-type scale. Measurements and Main Results: The survey was completed by 185 physicians, with a response rate of 29% (n = 185/634) for all physicians contacted. A majority (74%) of respondents reported that there was at least 1 component of an ASP at their institution. Most (86%) respondents agreed or strongly agreed that the patients in their ICU benefit from an ASP, with 81% reporting the ASP increases their knowledge of appropriate antimicrobial use in the ICU setting. Only 11% of respondents reported they felt that time spent interacting with the ASP team was an inefficient use of their time, and only 7% expressed concern that the ASP negatively affected their autonomy. Conclusion: Based on our survey results, Canadian intensivists are supportive of antimicrobial stewardship in ICUs and feel that ASPs provide a valuable service to both patients and clinicians.
Single-Incision Lateral Approach for Triple Arthrodesis
Authors: Moore Blake E. , Wingert Nathaniel C. , Irgit Kaan S. , Gaffney Christian J. , Cush Gerard J. 
Published: July 2014

Background: Triple arthrodesis is a powerful hindfoot corrective procedure involving fusion of the talonavicular (TN), calcaneocuboid (CC), and subtalar (ST) joints. A 2-incision approach, a single-incision medial triple arthrodesis, and a single-incision medial double arthrodesis are well described. We present a single-incision lateral approach to triple arthrodesis. Methods: We retrospectively reviewed 70 patients who underwent triple arthrodesis at our institution from 2007 to 2011. Patients had either double-incision (n = 33) or single-incision lateral (n = 37) triple arthrodesis. A single surgeon performed all procedures. The most common diagnosis was stage III planovalgus deformity. Deformity correction, union rate, time of surgery, complications, wound healing, reoperations, and pre- and postoperative visual analog scale (VAS) pain scores were analyzed for both groups. Results: There were no statistical differences in deformity correction, wound healing, complications, reoperations, or improvement in VAS pain scores. Operation time was significantly shorter in the single-incision lateral group (86 minutes vs 95 minutes, P = .0395). There was no difference in union rates with regard to the TN, ST, or CC joints. Five patients had radiographic nonunions of the CC joint between both groups. Conclusions: This is the first study that presents outcomes of a single lateral approach for triple arthrodesis. The single-incision approach was faster. The low rate of symptomatic nonunions suggests that fusion of the CC joint may not be important in symptomatic relief or deformity correction. Level of Evidence: Level III, retrospective comparative study.
Timing of surgical reconstruction for closed traumatic injury to the supraclavicular brachial plexus
Authors: Birch R. 
Published: July 2014

While it is widely accepted that cases of traumatic injury to the brachial plexus benefit from early surgical exploration and repair, with results deteriorating with long delays, policies vary regarding the exact timing of intervention. This is one of a pair of review articles considering the clinical issues, investigations, and surgical factors relating to management of injuries to the supraclavicular brachial plexus, as well evidence from experimental work and clinical outcomes. In this article Professor Birch argues for early exploration of the brachial plexus as the optimum both to delineate the pathology and undertake reconstructive surgery.
Timing of surgical reconstruction for closed traumatic injury to the supraclavicular brachial plexus
Authors: Hems T.E.J. 
Published: July 2014

While it is widely accepted that cases of traumatic injury to the brachial plexus benefit from early surgical exploration and repair, with results deteriorating with long delays, policies vary regarding the exact timing of intervention. This is one of a pair of review articles considering the clinical issues, investigations, and surgical factors relating to management of injuries to the supraclavicular brachial plexus, as well as evidence from experimental work and clinical outcomes. In this article Mr Hems outlines when waiting may be advantageous, allowing for further investigation to help clarify the extent of the injury and thus the best surgical options.
CT angiography-guided single-stage release of adjacent webspaces in non-Apert syndactyly
Authors: Hynes S. L. , Harvey I. , Thomas K. , Copeland J. , Borschel G. H. 
Published: July 2014

We describe the CT angiography protocol and surgical technique utilized at our institution for single-stage release of adjacent web-spaces in non-Apert syndactyly. In a series of seven consecutive hands we analyse syndactyly anatomy, CT angiographic findings, operative details, and complications. Outcomes were assessed with a functional activity evaluation, range of motion, and a parental visual analogue scale. Seven affected hands in four patients underwent single-stage release of adjacent webspaces. In all cases, the CT angiogram correctly predicted the presence of at least one artery supplying each digit. There were no cases of digital ischemia or loss. Angiographically guided, single-stage release of adjacent webspaces is technically feasible and benefits patients by reducing the number of surgical stages and allowing complete release to be achieved at an earlier age compared with the standard multi-stage approach. Level of Evidence: IV
Measuring Sesamoid Position in Hallux Valgus
Authors: Catanese Dominic , Popowitz Daniel , Gladstein Aharon Z. 
Published: July 2014

Measuring tibial sesamoid position is an important component of the preoperative radiographic evaluation of hallux valgus as it helps guide the surgeon in surgical selection. Tibial sesamoid position is typically measured on an anteroposterior (AP) radiograph on a scale from 1 to 7 as described by Hardy and Clapham. Some authors have advocated measuring the position on the sesamoid axial view, noting that the AP and axial views often yield different measurements. There is no consensus as to which view is more helpful in guiding the surgeon’s surgical decision. Weightbearing radiographs of 99 feet in patients with a clinical diagnosis of hallux valgus were retrospectively reviewed. Tibial sesamoid position was measured on the AP view using the 7-point scale of Hardy and Clapham. Tibial sesamoid position was also measured on the axial radiograph. Cohen’s kappa statistic was used to assess agreement of measurements obtained on the 2 views. There was poor agreement of the AP and axial views, with a kappa of 0.31. In our analysis of the data, it was determined that the lack of agreement was due mainly to X-rays showing tibial sesamoid positions of 4 and 5. A subgroup analysis of all X-rays with tibial sesamoids in positions other than 4 or 5 showed excellent agreement, with a kappa of 0.95. Anteroposterior and sesamoid axial views of feet with hallux valgus show excellent agreement in patients with the tibial sesamoid in positions other than 4 or 5. If the tibial sesamoid has a position of 4 or 5 on the AP, an axial view may be warranted to further understand the extent of deformity. Levels of Evidence: Diagnostic, Level IV: Case series
Telomerase Activity in Articular Chondrocytes Is Lost after Puberty
Authors: Wilson Brooke , Novakofski Kira D. , Donocoff Rachel Sacher , Liang Yan-Xiang Amber , Fortier Lisa A. 
Published: July 2014

Objective: Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype is desired for cartilage repair procedures. The objective of this study was to identify at what age chondrocytes and at what passage bone marrow–derived mesenchymal stem cells (MSCs) become senescent based on telomerase activity. The effect of osteogenic protein–1 (OP-1) or interleukin-1α (IL-1α) treatment on telomerase activity in chondrocytes was also measured to determine the response to anabolic or catabolic stimuli. Methods: Articular cartilage was collected from horses ( n = 12) aged 1 month to 18 years. Chondrocytes from prepubescent horses (<15 months) were treated with OP-1 or IL-1α. Bone marrow aspirate from adult horses was collected and cultured for up to 10 days to isolate MSCs. Telomerase activity was measured using the TeloTAGGG Telomerase PCR ELISA kit. Results: Chondrocytes from prepubescent horses were positive for telomerase activity. Treatment with IL-1α resulted in a decrease in chondrocyte telomerase activity; however, treatment with OP-1 did not change telomerase activity. One MSC culture sample was positive for telomerase activity on day 2; all samples were negative for telomerase activity on day 10. Conclusions: These results suggest that chondrocytes from prepubescent donors are potentially more suitable for cartilage repair procedures and that telomerase activity is diminished by anabolic and catabolic cytokine stimulation. If MSCs are utilized in cartilage repair, minimal passaging should be performed prior to implantation.
Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish
Authors: Wei Yonglong , Ma Dongyuan , Gao Ya , Zhang Chunxia , Wang Lu , Liu Feng 
Published: July 2014

Key PointsNcor2 is essential for HSC emergence in zebrafish. Ncor2 inhibits Fos-Vegfd signaling through recruitment of histone deacetylase 3 (Hdac3).
A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value
Authors: Chen Wen-Lian , Wang Jing-Han , Zhao Ai-Hua , Xu Xin , Wang Yi-Huang , Chen Tian-Lu , Li Jun-Min , Mi Jian-Qing , Zhu Yong-Mei , Liu Yuan-Fang , Wang Yue-Ying , Jin Jie , Huang He , Wu De-Pei , Li Yan , Yan Xiao-Jing , Yan Jin-Song , Li Jian-Yong , Wang Shuai , Huang Xiao-Jun , Wang Bing-Shun , Chen Zhu , Chen Sai-Juan , Jia Wei 
Published: July 2014

Key Points
Acute myeloid leukemia (AML) patients present an altered glucose metabolism signature. A panel of 6 metabolite biomarkers involved in glucose metabolism are identified with prognostic value for cytogenetically normal AML.
Real-world data on prognostic factors and treatment in peripheral T-cell lymphomas: a study from the Swedish Lymphoma Registry
Authors: Ellin Fredrik , Landström Jenny , Jerkeman Mats , Relander Thomas 
Published: July 2014

Key Points
Population-based data show a favorable outcome with upfront autologous stem cell transplantation in PTCL. The addition of etoposide to CHOP was associated with favorable PFS in patients ≤60 years with PTCL.
Searching algorithm of theodolite auto-focusing based on compound focal judgment
Authors: Liu Chun-tong , He Zhen-xin , Zhan Ying , Li Hong-cai 
Published: July 2014

Abstract
Focusing of search judgment is one of the important parts of theodolite image measurement. Traditional hill-climbing search algorithm cannot usually focus accurately due to the interference of the evaluation function of the local extremum affected by measuring environment, such as light illumination. A compound auto-focal judgment combining image definition evaluation function and modulation transfer function (MTF) auxiliary function was introduced to improve the hill-climbing method. Definition evaluation function and MTF values of images were considered to judge the search direction together. Slanted-edge method was improved to calculate the image MTF values accurately based on the auto-selection of slanted-edge area. Lastly, the principle and implementation of the improved algorithm were given. In the theodolite auto-focusing system, the system imaging effect was validated, and different initial position and circumstances were considered using the proposed searching algorithm. The experiment results of theodolite auto-focus system show that the improved hill-climbing search algorithm can effectively eliminate the local extremum disturbance and make the system search focusing accurate and reliable.
Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?
Authors: Han Weiyu , Cai Shiji , Liu Zhenhua , Jin Xingzhong , Wang Xia , Antony Benny , Cao Yuelong , Aitken Dawn , Cicuttini Flavia , Jones Graeme , Ding Changhai 
Published: July 2014

Abstract
Introduction
Recent studies regarding the infrapatellar fat pad (IPFP) mainly focus on the roles of the cells derived from the IPFP. There have been few clinical or epidemiological studies reporting on the association between the IPFP and knee osteoarthritis (OA). Our objective is to generate hypotheses regarding the associations between IPFP maximum area and knee OA measures in older adults.

Methods
A total of 977 subjects between 50 and 80 years of age (mean, 62.4 years) participated in the study. Radiographic knee osteophyte and joint space narrowing (JSN) were assessed using the Osteoarthritis Research Society International atlas. T1- or T2-weighted fat suppressed magnetic resonance imaging (MRI) was utilized to assess IPFP maximum area, cartilage volume, cartilage defects, and bone marrow lesions (BMLs). Knee pain was assessed by self-administered Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire.

Results
After adjustment for potential confounders, IPFP maximum area was significantly associated with joint space narrowing (odds ratio (OR): 0.75, 95% confidence interval (CI): 0.62 to 0.91 (medial), 0.77, 95% CI: 0.62 to 0.96 (lateral)) and medial osteophytes (OR: 0.52, 95% CI: 0.35 to 0.76), knee tibial and patellar cartilage volume (β: 56.9 to 164.9 mm3/cm2, all P <0.001), tibial cartilage defects (OR: 0.58, 95% CI: 0.41 to 0.81 (medial), 0.53, 95% CI: 0.40-0.71 (lateral)), any BMLs (OR: 0.77, 95% CI: 0.63 to 0.94), and knee pain on a flat surface (OR: 0.79, 95% CI: 0.63 to 0.98). IPFP maximum area was negatively, but not significantly, associated with femoral cartilage defects, lateral tibiofemoral BMLs, and total knee pain or other knee pain subscales.

Conclusion
IPFP maximum area is beneficially associated with radiographic OA, MRI structural pathology and knee pain on a flat surface suggesting a protective role for IPFP possibly through shock absorption. Consequently, we must pay special attention to IPFP in the clinical settings, avoiding resection of normal IPFP in knee surgery.
Unified Treatment of One-Range Addition Theorems for Complete Orthonormal Sets of Generalized Exponential-Type Orbitals and Noninteger n Slater Functions
Authors: Guseinov Israfil I 
Published: July 2014

Abstract
By the use of L(pl*)-generalized Laguerre polynomials (L(pl*)-GLPs) introduced by the author, the combined formulas for the one- and two-center one-range addition theorems of complete orthonormal sets of φ (pl*)-generalized exponential-type orbitals (φ (pl*)-GETOs) and χ-noninteger n Slater type orbitals (χ-NISTOs) in terms of χ-integer STOs (χ-ISTOs) are suggested, where pl* = 2l + 2 − α* and α* are the integer (α* = α, −∞ &lt; α ≤ 2) or noninteger (α* ≠ α, −∞ &lt; α* &lt; 3) self-frictional quantum numbers. The series expansion coefficients of these theorems are expressed through the overlap integrals over χ-NISTOs. As an application, the Combined Hartree–Fock–Roothaan (CHFR) total energy values for the ground states of some atoms obtained in the minimal basis set approximation are presented.
Clinical use and safety of a novel gentamicin-releasing resorbable bone graft substitute in the treatment of osteomyelitis/osteitis
Authors: Fleiter N. , Walter G. , Bösebeck H. , Vogt S. , Büchner H. , Hirschberger W. , Hoffmann R. 
Published: July 2014

ObjectiveA clinical investigation into a new bone void filler is giving first data on systemic and local exposure to the anti-infective substance after implantation.MethodA total of 20 patients with post-traumatic/post-operative bone infections were enrolled in this open-label, prospective study. After radical surgical debridement, the bone cavity was filled with this material. The 21-day hospitalisation phase included determination of gentamicin concentrations in plasma, urine and wound exudate, assessment of wound healing, infection parameters, implant resorption, laboratory parameters, and adverse event monitoring. The follow-up period was six months.ResultsSystemic exposure to gentamicin after implantation was very low as local gentamicin concentrations were measured in wound exudate after six to ten hours. There were no signs of infectious complication throughout the clinical phase. Four patients had recurrent infections several weeks to months after implantation. The outcome was deemed successful by remission of infection in 16 (80%) of these problematic long-term treated patients. Safety laboratory measurements did not indicate nephrotoxic or hepatotoxic effects.ConclusionsLocal application of calcium sulphate/carbonate bone void filler comprising gentamicin revealed sufficient active local levels of the antibiotic by simultaneous significant low systemic exposure in patients with mostly chronic osteomyelitis/osteitis. The material was safe and well tolerated. Cite this article: Bone Joint Res 2014;3:223–9.