bluuebunny/crossref_metadata_2025_split huggingface dataset:
The up‐regulation of PD‐L1 during boningmycin‐induced senescence in human cancer cells depends on the activation of the JAK/STAT signaling pathway mediated by SASP
Authors: Chen Yang , Shen Jiajia , Zhao Xiaoli , He Qiyang , Zhang Juan 
Published: July 2024

AbstractTherapy‐induced senescence can regulate both the innate and adaptive immune systems, thereby affecting therapeutic efficacy. Bleomycin is a major component of combined chemotherapy regimens, utilized for the treatment of multiple tumors, whereas pulmonary toxicity severely restricts its clinical benefits. As a member of the bleomycin family, boningmycin (BON) exhibits potent anticancer activity with minimal pulmonary toxicity, making it a potential alternative to bleomycin. Low concentrations of BON can induce senescence, but the impact of BON‐induced senescence on anticancer immunity remains unclear. This study investigates the effects of BON‐induced senescence on PD‐L1 expression and the underlying mechanisms in human cancer cells. Firstly, the elevation of PD‐L1 protein during BON‐induced senescence was confirmed by a senescence β‐galactosidase staining assay, detection of the senescence‐associated secretory phenotype (SASP), western blot and flow cytometry in human lung cancer NCI‐H460 cells and breast cancer MDA‐MB‐231 cells. Subsequently, it was shown that the increase in PD‐L1 protein is mediated by SASP, as evidenced by the use of conditional media, knockdown of cyclic GMP‐AMP synthase and inhibition of stimulator of interferon genes. Ultimately, it was demonstrated that SASP‐mediated PD‐L1 up‐regulation is dependent on the activation of the JAK/STAT pathway through the use of specific inhibitors and siRNAs. These findings clarify the impact of BON‐induced senescence on PD‐L1 expression and may contribute to the optimization of the therapeutic efficacy of bleomycin‐related compounds and the clinical transformation of BON.
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Authors: Siniscalco Emily R. , Williams Adam , Eisenbarth Stephanie C. 
Published: July 2024

SummaryThe increasing prevalence of food allergy and related pathologies in recent years has underscored the need to understand the factors affecting adverse reactions to food. Food allergy is caused when food‐specific IgE triggers the release of histamine from mast cells. However, other food‐specific antibody isotypes exist as well, including IgG and IgA. IgA is the main antibody isotype in the gut and mediates noninflammatory reactions to toxins, commensal bacteria, and food antigens. It has also been thought to induce tolerance to food, thus antagonizing the role of food‐specific IgE. However, this has remained unclear as food‐specific IgA generation is poorly understood. Particularly, the location of IgA induction, the role of T cell help, and the fates of food‐specific B cells remain elusive. In this review, we outline what is known about food‐specific IgA induction and highlight areas requiring further study. We also explore how knowledge of food‐specific IgA induction can be informed by and subsequently contribute to our overall knowledge of gut immunity.
The journey toward disease modification in cow milk protein allergy
Authors: Nocerino Rita , Carucci Laura , Coppola Serena , Oglio Franca , Masino Antonio , Agizza Alessandra , Paparo Lorella , Berni Canani Roberto 
Published: July 2024

SummaryCow milk protein allergy (CMPA) is one of the most common food allergies in the pediatric age worldwide. Prevalence, persistence, and severity of this condition are on the rise, with a negative impact on the health‐related quality of life of the patients and families and on the costs related to its management. Another relevant issue is that CMPA in early life may be the first stage of the “allergic march,” leading to the occurrence of other atopic manifestations later in life, especially asthma, atopic eczema, urticaria, and rhinoconjunctivitis. Thus, “disease modification” options that are able to modulate the disease course of pediatric patients affected by CMPA would be very welcomed by affected families and healthcare systems. In this review, we report the most relevant progress on this topic.
The process of developing and implementing health and nursing policy: Implications of research and opportunities to influence
Authors: Unsworth John , Puthenpurakal Alwin 
Published: July 2024

AbstractAimTo provide insight into the process of developing health and nursing policy and how that process can be influenced by both researchers and nursing leaders.BackgroundNurses care for people across the life course from birth to death, in our communities, hospitals, care homes and schools. They have unique insight into how people live their lives and how this affects their health. Despite being well placed to influence health policy, nurses often fail to capitalise on this. At the same time, academics often struggle to identify the policy implications of their research resulting in further missed opportunities to use policy influence.Sources of evidenceClassical policy theory, which is predominantly drawn from economics and public administration together with a range of contemporary nursing and health policy studies, is used in this paper to discuss the policy process and opportunities to influence.DiscussionResearchers need to focus on realistic policy suggestions that aim to raise awareness, highlight policy problems or set the agenda. In turn, nursing leaders, from National Nursing Associations, need to harness evidence to support their efforts to influence policy. In terms of influence, a range of approaches exist, and each lends itself to different parts of the policy cycle.ConclusionThe role nurses can play in health policy is not well developed in many countries. Nursing researchers and leaders are well placed to influence policy but must do so in a clear and pragmatic way recognising that policymakers make decisions despite being faced with conflicting evidence, competing demands and economic imperatives.Implications for nursing practiceRecognising that nurses can offer much in terms of policy development, the paper argues that a pragmatic approach based on different forms of influence at different stages is likely to be most successful.Implications for nursing and health policyThe evidence reviewed in this paper suggests that nursing academics and leaders need to identify realistic policy interventions when examining their own empirical work or identifying ways to individually or collectively influence policymakers.
Factors associated with toothbrushing performance among children: An observational cohort study
Authors: Matalon Vered , Levin Liran , Yagudaev Michael , Ashkenazi Malka 
Published: July 2024

AbstractBackgroundEffective removal of dental plaque is essential factor for prevention of caries, gingival, and periodontal diseases in children and adults.AimTo evaluate factors associated with improving toothbrushing performance (TB‐P) among children.DesignAn observational cohort study analyzed all paediatric patients receiving regular examinations in a single dental clinic between 2009 and 2017 and regularly brushing their teeth with a triple‐headed toothbrush (TH‐TB). At every periodic follow‐up, the TB‐P of the child/parent was evaluated using the TB‐P Skill Index (TB‐PS‐I); that is, did the child reach all five teeth segments within each arch and did he/she perform 10 back‐and‐forth stocks in each segment. When not optimal, they received instructions for improving TB‐P and subsequently were asked to re‐demonstrate. TB‐PS‐I was calculated and analyzed for correlation with other explanatory variables.ResultsA total of 1737 children with 7399 follow‐up appointments were analyzed. Older age, female gender, higher number of follow‐up appointments, and compliance with twice‐daily toothbrushing significantly improved TB‐P. The most typical mistakes in their performance were not reaching the canine segments and not performing enough strokes in each segment. Instructions given after imperfect TB‐P significantly improved the TB‐P. The magnitude of improvement, however, did not correlate with the performers' age, gender, or the number of follow‐up visits.ConclusionsA significant percentage of children >8 years did not perform optimal toothbrushing even when using TH‐TB.
Process evaluation of a parenting intervention for pre‐schoolers with intellectual disabilities who display behaviours that challenge in the UK
Authors: Ondrušková Tamara , Oulton Kate , Royston Royston ,   EPICC‐ID Research Group, Hassiotis Angela 
Published: July 2024

AbstractBackgroundStepping Stones Triple P (SSTP) is a complex parent‐mediated intervention aimed to reduce behaviours that challenge in children with moderate to severe intellectual disabilities, aged 30–59 months.MethodsTo formulate a comprehensive understanding of SSTP implementation in the UK, we conducted a process evaluation collecting stakeholder views and considering intervention fidelity, dose, reach, delivery adaptations, and acceptability.ResultsFidelity and quality of delivery ratings were high. Parents perceived SSTP as valuable, reporting increased parental confidence and understanding of the child's behaviours. However, only 30% of families received an adequate dose of the intervention. Parents who only received treatment as usual described feeling abandoned by current services. Service managers emphasised the importance of availability of resources and therapist training for successful intervention delivery.ConclusionsSSTP supports effective management of early‐onset behaviours that challenge. Further work is needed to ensure equitable access to the intervention across health and social care services.Trial RegistrationNCT03086876 – https://www.clinicaltrials.gov/ct2/show/NCT03086876?term=Hassiotis+Angela&draw=1&rank=1.
Effect of tangeretin on cisplatin‐induced oxido‐inflammatory brain damage in rats
Authors: Cicek Betul , Danisman Betul , Bolat Ismail , Kiliclioglu Metin , Kuzucu Mehmet , Suleyman Halis , Tsarouhas Konstantinos , Tsatsakis Aristidis , Taghizadehghalehjoughi Ali 
Published: July 2024

AbstractCisplatin (CIS) is a platinum‐derived chemotherapeutic agent commonly utilized in the treatment of various malignant tumours. However, anticancer doses of the drug cause serious damage to the brain. This study aimed to determine the potential protective effects of tangeretin, which has antioxidant and anti‐inflammatory properties, in cisplatin‐induced neurotoxicity on BALB/c mice brains. Male BALB/c mice were randomized and separated into four groups. Tangeretin was given for 10 days by gavage. CIS was injected as a single dose of 10 mg/kg intraperitoneally (ip) on the 10th day. Brain tissues, malondialdehyde (MDA), total glutathione (tGSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and nitric oxide (NO) levels were measured to determine oxidative damage and myeloperoxidase, tumour necrosis factor‐alpha (TNF‐α), interleukin 1 beta (IL‐1β), IL‐6 and IL‐10 were measured to determine inflammatory activity. In addition, 8‐OHdG and caspase‐3 were analysed by immunofluorescence methods. While CIS administration remarkably elevated reactive oxygen species, MDA, and NO levels in brain tissue compared to the control, tGSH, GPx, SOD and CAT levels were significantly decreased. Also, it has been detected that TNF‐α, IL‐1β and IL‐6 obtained in CIS‐treated groups increased as well as IL‐10 decreased, thereby elevating the inflammatory response. In addition, 8‐OHdG and caspase‐3 immunoreactivity in neurons increased with CIS administration. Treatment with tangeretin ameliorated the deterioration in oxidant/antioxidant status, overpowered neuroinflammation and ameliorated neurotoxicity‐induced apoptosis. This study shows that tangeretin has beneficial effects on CIS‐induced neurodegeneration. Possible mechanisms underlying these beneficial effects include the antioxidant and anti‐inflammatory properties of tangeretin.
Mutual fund partial liquidation and future performance
Authors: Jiang George , McLemore Ping , Wang Ao 
Published: July 2024

AbstractWe examine the determinants of mutual fund partial liquidation and the effect of a negative shock to fund size on performance. We find that older funds from a smaller family with a large number of share classes are more likely to conduct partial liquidation. As fund size decreases after partial liquidation, its performance improves. This effect is more pronounced for funds with stronger pre‐event liquidity constraint and funds that subsequently experience a larger decrease in liquidity, suggesting that liquidity constraint is a contributing factor of fund performance. These findings are consistent with mutual funds having decreasing returns to scale.
How do victims of bullying develop depression? Testing interpersonal style to explain the victimization‐depression link
Authors: Franzen Minita , van Duijn Marijtje A. J. , de Jong Peter J. , Veenstra René , aan het Rot Marije 
Published: July 2024

AbstractThis study tested to what extent the relation between bullying victimization and future symptoms of depression could be explained by victims being more hostile and less assertive than non‐involved individuals. Data came from waves 2–4 of the Dutch TRacking Adolescents' Individual Lives Survey (TRAILS). Participants' bullying experiences were assessed at age 13, interpersonal style at age 16, and depression symptoms at age 19. Mediation analyses were performed primarily on 274 self‐reported victims and 1498 non‐involved peers. Self‐reported victims had an increased risk for depression symptoms. About a third of that risk could be explained by victims' hostile style, which was also higher than those of non‐involved peers. Although victims also reported lower levels of assertiveness than non‐involved peers, this interpersonal style did not mediate the link between bullying victimization and depression. Our findings suggest that high hostility, but not low assertiveness, partly explains the increased depression risk of self‐reported victims. Therefore, interventions could focus on addressing hostility, to help reduce the likelihood that adolescents who have experienced bullying victimization will have more interpersonal conflicts and mental health problems in the future. Supplementary materials also include analyses for bullies and bully‐victims, and for peer‐reported measures.
The role of treatment of hepatitis C with direct‐acting antiviral agents on glycaemic control in diabetic patients: An updated systematic review and meta‐analysis
Authors: Chen Bing , Iqbal Umair , Desai Shivani K. , Gries Jacob , Verheyen Elijah , Xie Mengdan , El Halabi Maan , Gaines Sara , Weisberg Ilan 
Published: July 2024

AbstractRecent studies suggested that successful clearance of chronic Hepatitis C Virus (HCV) by using direct‐acting antiviral (DAA) agents could improve glycemic control in patients with diabetes; however, some studies failed to identify this benefit. We conducted a systematic review and meta‐analysis to assess the impact of sustained virologic response (SVR) after treatment with DAA agents on glycemic control. Embase, Scopus and PubMed were searched through March 26th, 2023, for all studies evaluating whether eradication of HCV infection with DAAs is associated with an impact on glycemic control. Only studies with data on glycemic control, including haemoglobin A1c (HbA1c), fasting glucose, or Homeostatic Model Assessment for Insulin Resistance (HOMA‐IR), at least 12‐week post‐SVR were included. Sixteen studies met our eligibility criteria and were included in qualitative analysis. The mean HbA1c was 8.05% (95% CI: 7.79%–8.31%) before treatment and 7.19% (95% CI: 6.98%–7.39%) after treatment. There was a significant mean absolute reduction in HbA1c of 0.72% (95% CI: 0.52%–0.93%) with high heterogeneity between studies (I2 = 91.7%). The reduction in HbA1c remained significant in the subgroup analysis at 3 months follow up post SVR [0.74% (95% CI: 0.57%–0.91%)] and at least 6 months follow up [0.66% (95% CI: 0.23%–1.10%)]. We found a significant reduction in HbA1C after SVR in patients with type 2 diabetes mellitus, reflecting better glycemic control with HCV eradication. This data highlights an important extrahepatic benefit of HCV eradication.
Anthropometric and sociodemographic variables, but not preconception or prenatal maternal nutrition supplementation, predict neurodevelopment in offspring of the ‘Women First’ trial
Authors: Waldrop Stephanie , Chowdhury Dhuly , Westcott Jamie E. , Biasini Fred , Garcés Ana , Figueroa Lester , Tshefu Antoinette , Lokangaka Adrien , Bauserman Melissa , Saleem Sarah , Ali Sumera A. , Goldenberg Robert L. , Goudar Shivaprasad S. , Dhaded Sangappa M. , Derman Richard J. , Kemp Jennifer F. , Koso‐Thomas Marion , Das Abhik , Hambidge Michael , Krebs Nancy F. ,   The Women First Preconception Nutrition Trial Study Group
Published: July 2024

AbstractMultiple factors influence infant and child neurodevelopment in low resource settings. In offspring of participants in the preconception maternal nutrition trial, Women First (WF), we examined the impact of providing a preconception (Arm 1) or prenatal (Arm 2) nutrient supplement (compared to controls, Arm 3) on neurodevelopmental outcomes at 24 months; predictors of neurodevelopment scores; and associations of infant anthropometrics with neurodevelopmental scores. Follow‐up visits for anthropometry were conducted at 6‐, 12‐, 18‐ and 24‐month of age. At 24‐months, in a randomized subset, the Bayley Scales of Infant Development, 3rd edition (BSID‐III), including cognitive, motor and social‐emotional subscales, and the Family Care Indicators (FCI) questionnaire, assessing family and home environment, were completed. Multiple covariates (intervention arm, site, maternal sociodemographic characteristics, FCI subscales, birthweight and 6–24 months' change in anthropometry z‐scores, (e.g., ΔLAZ6–24) were evaluated by linear regression to predict BSID‐III outcomes and to assess associations of anthropometric changes with BSID‐III scores. The analysis consisted of 1386 infants (n = 441, 486, 459 for Arms 1, 2 and 3, respectively). None of the domain‐specific BSID‐III subscale scores differed by maternal intervention arm. Four covariates significantly predicted (p ≤ 0.01) all 3 BSID‐III subscales: secondary maternal education, ΔLAZ6–24, birthweight >2500 g, and FCI play materials. Linear growth was associated with all domains of neurodevelopment. The results underscore the multi‐dimensional aspects of child development represented by the nurturing care framework, including prenatal maternal nutrition, post‐natal growth, maternal education for responsive caregiving and opportunities for early learning.
Legacy of the British Mandate: Eliminating The Palestinian Right to Self‐Determination
Authors: Iriqat Dalal 
Published: July 2024

AbstractIn February 2024, Prime Minister Benjamin Netanyahu issued a plan for the “postwar” Gaza Strip that envisions Israel's military as unilaterally and indefinitely patrolling the enclave while an unnamed third party runs the local government. While even allies like the United States criticized this scheme, Palestine has never enjoyed autonomy as a state, and the institutions and practices of Israel's far‐right government—and even of the Palestinian elite—are rooted in the settler colonialism facilitated by the British mandate, 1922–1948. This period was the first and last time in modern history that Palestinian Arabs and Jews were administered as a single polity, albeit on radically unequal terms. This article examines how international law was used to suppress the Palestinians and privilege the creation of a Jewish state of Israel. The legacy of this regime can be seen in the present‐day thwarting of Palestinian self‐determination through Israel's use of the military for civil administration, digital surveillance, and the right‐wing agenda for annexation of the West Bank and perpetual war in Gaza.
Cassandra and A Room of One's Own: A common cry of frustration
Authors: Choperena Ana , Díaz‐Dorronsoro Inés 
Published: July 2024

AbstractIn this manuscript, we explore the connections between Florence Nightingale's Cassandra and Virginia Woolf's A Room of One's Own while taking the authors' personal and social contexts into account. We conduct a detailed textual analysis from a feminist perspective. Cassandra and A Room of One's Own exhibit singular textual commonalities, such as evidence of trauma, the integration of myth and fiction as literary devices aimed at facilitating the author's access to various social spheres, the use of interpellations to impact the audience, and an argument for education as a path by which privileged women can enter the public realm. Both authors' personal wounds and intellectual frustrations influenced their work, thus making their writing very powerful.
m6A demethylase OsALKBH5 is required for double‐strand break formation and repair by affecting mRNA stability in rice meiosis
Authors: Xue Feiyang , Zhang Jie , Wu Di , Sun Shiyu , Fu Ming , Wang Jie , Searle Iain , Gao Hongbo , Liang Wanqi 
Published: July 2024

Summary
N6‐methyladenosine (m6A) RNA modification is the most prevalent messenger RNA (mRNA) modification in eukaryotes and plays critical roles in the regulation of gene expression. m6A is a reversible RNA modification that is deposited by methyltransferases (writers) and removed by demethylases (erasers). The function of m6A erasers in plants is highly diversified and their roles in cereal crops, especially in reproductive development essential for crop yield, are largely unknown.
Here, we demonstrate that rice OsALKBH5 acts as an m6A demethylase required for the normal progression of male meiosis.
OsALKBH5 is a nucleo‐cytoplasmic protein, highly enriched in rice anthers during meiosis, that associates with P‐bodies and exon junction complexes, suggesting that it is involved in regulating mRNA processing and abundance. Mutations of OsALKBH5 cause reduced double‐strand break (DSB) formation, severe defects in DSB repair, and delayed meiotic progression, leading to complete male sterility. Transcriptome analysis and m6A profiling indicate that OsALKBH5‐mediated m6A demethylation stabilizes the mRNA level of multiple meiotic genes directly or indirectly, including several genes that regulate DSB formation and repair.
Our study reveals the indispensable role of m6A metabolism in post‐transcriptional regulation of meiotic progression in rice.
How to do HRM with numbers? A performative lens on HR metrics, HR analytics and HR algorithms
Authors: Coron Clotilde , Scheibmayr Isabella , Lescoat Pierre 
Published: July 2024

AbstractThis study examines the performativity of using numbers in the context of human resource management (HRM). We use performativity as a theoretical lens to understand how such quantification affects individuals and work. We theorise three performative effects of quantification based on multiple case studies using internal documents and semi‐structured interviews. To do this we analysed six HRM quantification projects (including cases of algorithmic HRM) at a large French multinational corporation. Each use of quantification creates a specific form of performativity. Our work complements the sparse but growing literature on metrics, analytics and algorithms in Human Resources, focusing not on the kind of reality numbers represent but on how they impact different stakeholders.