bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urine output is an early and strong predictor of acute kidney injury and associated mortality: a systematic literature review of 50 clinical studies
Authors: Malbrain Manu L. N. G. , Tantakoun Krista , Zara Anthony T. , Ferko Nicole C. , Kelly Timothy , Dabrowski Wojciech 
Published: July 2024

Abstract
Background
Although the present diagnosis of acute kidney injury (AKI) involves measurement of acute increases in serum creatinine (SC) and reduced urine output (UO), measurement of UO is underutilized for diagnosis of AKI in clinical practice. The purpose of this investigation was to conduct a systematic literature review of published studies that evaluate both UO and SC in the detection of AKI to better understand incidence, healthcare resource use, and mortality in relation to these diagnostic measures and how these outcomes may vary by population subtype.

Methods
The systematic literature review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Data were extracted from comparative studies focused on the diagnostic accuracy of UO and SC, relevant clinical outcomes, and resource usage. Quality and validity were assessed using the National Institute for Health and Care Excellence (NICE) single technology appraisal quality checklist for randomized controlled trials and the Newcastle–Ottawa Quality Assessment Scale for observational studies.

Results
A total of 1729 publications were screened, with 50 studies eligible for inclusion. A majority of studies (76%) used the Kidney Disease: Improving Global Outcomes (KDIGO) criteria to classify AKI and focused on the comparison of UO alone versus SC alone, while few studies analyzed a diagnosis of AKI based on the presence of both UO and SC, or the presence of at least one of UO or SC indicators. Of the included studies, 33% analyzed patients treated for cardiovascular diseases and 30% analyzed patients treated in a general intensive care unit. The use of UO criteria was more often associated with increased incidence of AKI (36%), than was the application of SC criteria (21%), which was consistent across the subgroup analyses performed. Furthermore, the use of UO criteria was associated with an earlier diagnosis of AKI (2.4–46.0 h). Both diagnostic modalities accurately predicted risk of AKI-related mortality.

Conclusions
Evidence suggests that the inclusion of UO criteria provides substantial diagnostic and prognostic value to the detection of AKI.
Baseline and early 18F-FDG PET/CT evaluations as predictors of progression-free survival in metastatic breast cancer patients treated with targeted anti-CDK therapy
Authors: Lasnon Charline , Morel Adeline , Aide Nicolas , Silva Angélique Da , Emile George 
Published: July 2024

Abstract
Background
Exploring the value of baseline and early 18F-FDG PET/CT evaluations in prediction PFS in ER+/HER2- metastatic breast cancer patients treated with a cyclin-dependent kinase inhibitor in combination with an endocrine therapy.

Methods
Sixty-six consecutive breast cancer patients who underwent a pre-therapeutic 18F-FDG PET/CT and a second PET/CT within the first 6 months of treatment were retrospectively included. Metabolic tumour volume (MTV) and total lesion glycolysis (TLG) and Dmax, which represents tumour dissemination and is defined as the distance between the two most distant lesions, were computed. The variation in these parameters between baseline and early evaluation PET as well as therapeutic evaluation using PERCIST were assessed as prognosticators of PFS at 18 months.

Results
The median follow-up was equal to 22.5 months. Thirty progressions occurred (45.4%). The average time to event was 17.8 ± 10.4 months. At baseline, Dmax was the only predictive metabolic parameter. Patients with a baseline Dmax ≤ 18.10 cm had a significantly better 18 m-PFS survival than the others: 69.2% (7.7%) versus 36.7% (8.8%), p = 0.017. There was no association between PERCIST evaluation and 18 m-PFS status (p = 0.149) and there was no difference in 18 m-PFS status between patients classified as complete, partial metabolic responders or having stable metabolic disease.

Conclusion
Disease spread at baseline PET, as assessed by Dmax, is predictive of an event occurring within 18 months. In the absence of early metabolic progression, which occurs in 15% of patients, treatment should be continued regardless of the quality of the initial response to treatment.
Mobility-induced kinetic effects in multicomponent mixtures
Authors: Thewes F. C. , Krüger M. , Sollich P. 
Published: July 2024

Abstract
We give an overview exploring the role of kinetics in multicomponent mixtures. Compared to the most commonly studied binary (single species plus solvent) case, multicomponent fluids show a rich interplay between kinetics and thermodynamics due to the possibility of fractionation, interdiffusion of mixture components and collective motion. This leads to a competition between multiple timescales that change depending on the underlying kinetics. At high densities, crowding effects are relevant and non-equilibrium structures can become long-lived. We present the main approaches for the study of kinetic effects in multicomponents mixtures, including the role of crowding, and explore their consequences for equilibrium and non-equilibrium scenarios. We conclude by identifying the main challenges in the field.
Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study
Authors: Mayne Gabriella , DeWitt Peter E , Wen Jennifer , Schniedewind Björn , Dabelea Dana , Christians Uwe , Hurt K Joseph 
Published: July 2024

Abstract

Context
Adiponectin is a potent uterine tocolytic that decreases with gestational age, suggesting it could be a maternal metabolic quiescence factor. Maternal stress can influence preterm birth risk, and adiponectin levels may be stress responsive.

Objective
We characterized associations between adiponectin and glucocorticoids with preterm birth and modeled their predictive utility. We hypothesized maternal plasma adiponectin and cortisol are inversely related and lower adiponectin and higher cortisol associate with preterm birth.

Methods
We performed a nested case–control study using biobanked fasting maternal plasma. We included low-risk singleton pregnancies, and matched 1:3 (16 preterm, 46 term). We quantified high molecular weight (HMW), low molecular weight (LMW), and total adiponectin using an enzyme-linked immunosorbent assay. We validated a high-performance liquid chromatography-tandem mass spectrometry serum assay for use in plasma, to simultaneously measure cortisol, cortisone, and 5 related steroid hormones. We used linear/logistic regression to compare group means and machine learning for predictive modeling.

Results
The preterm group had lower mean LMW adiponectin (3.07 μg/mL vs 3.81 μg/mL at 15 weeks (w) 0 days (d), P = .045) and higher mean cortisone (34.4 ng/mL vs 29.0 ng/mL at 15w0d, P = .031). The preterm group had lower cortisol to cortisone and lower LMW adiponectin to cortisol ratios. We found HMW adiponectin, cortisol to cortisone ratio, cortisone, maternal height, age, and prepregnancy body mass index most strongly predicted preterm birth (area under the receiver operator curve = 0.8167). In secondary analyses, we assessed biomarker associations with maternal self-reported psychosocial stress. Lower perceived stress was associated with a steeper change in cortisone in the term group.

Conclusion
Overall, metabolic and stress biomarkers are associated with preterm birth in this healthy cohort. We identify a possible mechanistic link between maternal stress and metabolism for pregnancy maintenance.
The preclinical gap in pancreatic cancer and radiotherapy
Authors: Tesson Mathias , Morton Jennifer P. 
Published: July 2024

ABSTRACT
Pancreatic ductal adenocarcinoma is an aggressive malignancy with limited treatment options. Chemotherapy offers little benefit and, although there is some evidence that radiotherapy may improve response, its use in the clinical management of pancreatic cancer remains controversial due to conflicting reports on its survival benefit. There has also been a lack of clinical trials that directly investigate the efficacy of radiotherapy in pancreatic cancer. The limited progress in the development of radiotherapeutic strategies in pancreatic cancer can be attributed, at least in part, to a dearth of preclinical research and our limited understanding of the effects of radiation on the pancreatic tumour microenvironment. In this Perspective, we discuss how insight into the immunosuppressive tumour microenvironment and the complex signalling between tumour and stromal cells following radiation is needed to develop effective radiosensitising strategies for pancreatic cancer. We also highlight that to have the best chance for successful clinical translation, more preclinical research is required in appropriately complex models.
Modeling Multimodal Curbside Usage in Dynamic Networks
Authors: Liu Jiachao , Qian Sean 
Published: July 2024

The proliferation of emerging mobility technology has led to a significant increase in demand for ride-hailing services, on-demand deliveries, and micromobility services, transforming curb spaces into valuable public infrastructure for which multimodal transportation competes. However, the increasing utilization of curbs by different traffic modes has substantial societal impacts, further altering travelers’ choices and polluting the urban environment. Integrating the spatiotemporal characteristics of various behaviors related to curb utilization into general dynamic networks and exploring mobility patterns with multisource data remain a challenge. To address this issue, this study proposes a comprehensive framework of modeling curbside usage by multimodal transportation in a general dynamic network. The framework encapsulates route choices, curb space competition, and interactive effects among different curb users, and it embeds the dynamics of curb usage into a mesoscopic dynamic network model. Furthermore, a curb-aware dynamic origin-destination demand estimation framework is proposed to reveal the network-level spatiotemporal mobility patterns associated with curb usage through a physics-informed data-driven approach. The framework integrates emerging real-world curb use data in conjunction with other mobility data represented on computational graphs, which can be solved efficiently using the forward-backward algorithm on large-scale networks. The framework is examined on a small network as well as a large-scale real-world network. The estimation results on both networks are satisfactory and compelling, demonstrating the capability of the framework to estimate the spatiotemporal curb usage by multimodal transportation. History: This paper has been accepted for the Transportation Science Special Issue on ISTTT25. Funding: This material is based upon work supported by the Office of Energy Efficiency and Renewable Energy, U.S. Department of Energy [Award DE-EE0009659]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2024.0522 .
Cotton rat (Sigmodon toltecus) as part of the diet of the Neotropical otter (Lontra longicaudis annectens)
Authors: Vázquez-Maldonado Laura Elena , Hortelano-Moncada Yolanda , Berges-Cervera Paul Jafet , Delgado-Estrella Alberto , Vargas-Cuenca Julieta 
Published: July 2024

En México existen pocos registros de roedores en la dieta de Lontra longicaudis annectens, sólo hay 2 referencias con especies. El objetivo de esta nota fue analizar los hábitos alimentarios de la nutria neotropical, en la laguna Las Coloradas, adyacente al río Palizada, Campeche y evidenciar el consumo ocasional de rata algodonera (Sigmodon toltecus). Se recorrieron 6.63 km en una embarcación con motor fuera de borda en el borde poniente de esta laguna (2.21 km / temporada climática 2017-2018). Se colectaron heces y comederos, determinando el porcentaje de aparición (PA) de las especies presas consumidas para su identificación. De 176 heces y 4 comederos se identificaron 10 grupos zoológicos: los peces presentaron el mayor PA (36.74 %), seguido por gasterópodos (26.17 %), langostinos (11.58 %), cangrejos (8.56 %), insectos (8.05 %), reptiles (5.37 %), aves (2.85 %), mamíferos (0.34 %), bivalvos e isópodos (0.17 %, respectivamente). En la temporada de secas (2018), se registraron 2 cráneos y 2 dentarios de S. toltecus. En México se reconocen 10 de las 14 especies de ratas algodoneras, Sigmodon, de las cuales se conoce 1 especie para el estado de Campeche (S. toltecus). Este es el primer registro de depredación de roedores por parte de L. l. annectens en los sistemas fluvio-lagunares de Campeche. Este registro ocasional, amplía el espectro alimentario de la nutria neotropical y la distribución de S. toltecus dentro del Área de Protección de Flora y Fauna Laguna de Términos (APFFLT) y del estado.
Smell fruits selection behavior by a Geoffroy's spider monkey (Ateles geoffroyi) in Quintana Roo, México
Authors: Arias-Alzate Andrés , Zarza Heliot , Acevedo-Quintero Juan Fernando 
Published: July 2024

En primates, los sistemas sensoriales juegan un papel importante en la detección y selección de recursos. Aquí, reportamos un comportamiento ecológico poco estudiado, la selección olfativa de frutos en el mono araña de Geoffroy (Ateles geoffroyi), una especie de primate que se encuentra desde las regiones de Mesoamérica hasta el norte de Sudamérica. Observamos directamente, grabamos en video y describimos un comportamiento de selección de frutas usando el sentido del olfato por un mono araña de Geoffroy silvestre durante un evento de forrajeo en un árbol de Manilkara zapota, en una zona de selva tropical semi perennifolia al sur de Quintana Roo, México. Durante las observaciones, el mono araña examinó uno por uno los frutos de Manilkara zapota acercándolos a su nariz, lo que aparentemente le permitía distinguir entre frutos maduros e inmaduros. Los frutos que parecían inmaduros los soltaba de las ramas sin arrancarlos. Los frutos que parecían maduros, como sugiere la observación, eran arrancados y consumidos uno en uno. Este mecanismo de selección basado en el olfato hace frente a la creencia de que la visión y el gusto son los principales impulsores en la elección de alimentos para primates frugívoros. Destaca la relevancia de las señales sensoriales, especialmente el olfato, en la discriminación de la palatabilidad y subraya la influencia en la evolución de olores distintivos en plantas con frutas carnosas y crípticos.
EXPRESSÃO HUMORÍSTICA E RESPONSABILIDADE CIVIL
Authors: Simoni Adriel Borges , Amaral Ana Claudia Corrêa Zuin MAttos do 
Published: July 2024

O humor está presente desde os tempos mais remotos da história da humanidade, mas sua livre expressão tem entrado em rota de colisão com os direitos da personalidade, fato que se denota através da crescente dos casos de responsabilidade civil de humoristas por alegadas lesões à honra, intimidade e privacidade alheias. Na ausência de critérios seguros para a aferição da conduta lesiva dos humoristas frente aos direitos de personalidade de terceiros, não raro o Poder Judiciário tem buscado resolver as lides com base em gostos pessoais a respeito do conteúdo da mensagem humorística propagada para se delimitar, então, a existência de um dano ressarcível, método com o qual não se coaduna. Em igual medida, verifica-se que a técnica de ponderação carece de critérios seguros e unívocos para se delimitar a predominância dos direitos contrapostos. A metodologia aqui utilizada faz uso da técnica bibliográfica e de uma abordagem dedutiva na medida em que propõe a análise da conduta do humorista segundo a chamada culpa normativa, apontando-se critérios doutrinários e jurisprudência aplicável que fomentem a construção de um padrão de conduta do profissional do humor, cuja responsabilidade civil somente poderá ser atribuída se deste padrão houver um desvio. A análise da conduta lesiva do humorista à luz da culpa normativa deve promover maior segurança jurídica e previsibilidade na análise dos casos de responsabilidade civil dos profissionais do humor.
Palavras-chave: Humor. Liberdade de expressão. Responsabilidade civil. Culpa normativa. Limite do humor.
A phase II, multicenter, nonblinded, randomized controlled trial for evaluating protective effects of ABPC/SBT plus, azithromycin versus erythromycin, in pregnant women with pPROM occurring at <28 weeks of gestation on the development of BPD in neonates: Study protocol
Authors: Ohkuchi Akihide , Okazaki Kaoru , Iwamoto Shintaro , Sako Mayumi , Kobayashi Tohru , Yanagihara Itaru , Nomiyama Makoto ,   on behalf of the group of the PPROM-AZM study
Published: July 2024

This is a protocol for PPROM-AZM Study, phase II, nonblinded, randomized controlled trial. Bronchopulmonary dysplasia (BPD) at a postmenstrual age of 36 weeks (BPD36) is often observed in infants with preterm premature rupture of the membranes (pPROM). A regimen of ampicillin (ABPC) intravenous infusion for 2 days and subsequent amoxicillin (AMPC) oral administration for 5 days plus erythromycin (EM) intravenous infusion for 2 days followed by EM oral administration for 5 days is standard treatment for pPROM. However, the effect on the prevention of moderate/severe BPD36 using the standard treatment has not been confirmed. Recently, it is reported that ampicillin/sulbactam (ABPC/SBT) plus azithromycin (AZM) was effective for the prevention of moderate/severe BPD36 in pPROM patients with amniotic infection of Ureaplasma species. Therefore, our aim is to evaluate the occurrence rate of the composite outcome of “incidence rate of either moderate/severe BPD36 or intrauterine fetal death, and infantile death at or less than 36 weeks 0 days” comparing subjects to receive ABPC/SBT for 14 days plus AZM for 14 days (intervention group) and those to receive ABPC/SBT for 14 days plus EM for 14 days (control group), in a total of 100 subjects (women with pPROM occurring at 22–27 weeks of gestation) in Japan. The recruit of subjects was started on April 2022, and collection in on-going. We also investigate the association between the detection of Ureaplasma species and occurrence of BPD36. In addition, information on any adverse events for the mother and fetus and serious adverse events for infants are collected during the observation period. We allocate patients at a rate of 1:1 considering two stratification factors: onset of pPROM (22–23 or 24–27 weeks) and presence/absence of a hospital policy for early neonatal administration of caffeine.
Trial registration: The trial number in the Japan Registry of Clinical Trials is jRCTs031210631.
Suboptimal micronutrient intake among children aged 6 to 23 months in Ethiopia: Further analysis of the demographic and health survey
Authors: Fetene Samrawit Mihret , Negash Wubshet Debebe , Amare Tsegaw , Belachew Tadele Biresaw , Addis Banchlay , Asmamaw Desale Bihonegn , Kidie Atitegeb Abera , Endawkie Abel , Wubante Sisay Maru , Zegeye Alebachew Ferede , Tamir Tadesse Tarik , Fentie Elsa Awoke 
Published: July 2024

Background
The recommended essential micronutrient such as food rich in vitamin-A or iron, multiple micronutrient powder or iron supplement, routine daily consumption of iodine, and vitamin-A supplement are deficient among children in Ethiopia. This has been a significant public health problem despite the government efforts. Although few studies have examined the micronutrient intake among children, they are limited in scope and methodological measurements. Analyzing the micronutrient intake among children across all regions and leveraging all essential micronutrient elements are crucial for generating improved evidence to better inform policy. Thus, we examined the micronutrient intake among children aged 6 to 23 months in Ethiopia.

Methods
We used data from the Ethiopian Demographic and Health Survey. A two-stage stratified sampling technique was employed, and 1392 children aged 6 to 23 months were included in our analysis. We conducted a multilevel mixed-effect binary logistic regression analysis to identify determinants of micronutrient intake. In the final model, we used a p-value of less than 0.05 and Adjusted Odds Ratio (AOR) with their 95% confidence interval (CI).

Results
We found that only 27.6% (95% CI: 26.8–31.6) of children aged 6 to 23 months were received the recommended micronutrients in Ethiopia. We identified that maternal educational status (Educated mothers (AOR = 2.09, 95%CI:1.23–3.58)), health facility delivery (AOR = 2.14, 95%CI:1.42–2.98), household wealth status (middle quantile (AOR = 1.80, 95%CI:1.01–3.21)), children’s age (12 to 23 months age (AOR = 2.36, 95% CI: 1.33–4.21)), and mother’s exposure to media (AOR = 1.70, 95%CI: 1.42–2.04) were increased micronutrient intake, whereas residing in the rural communities (AOR = 0.27, 95%CI: 0.21–0.34) decreased micronutrient intake.

Conclusions
Nearly three-fourths of children aged 6 to 23 months did not receive the recommended essential micronutrients in Ethiopia. Therefore, there is a need to broaden strategies aimed at enhancing the intake by improving information and knowledge dissemination among mothers during facility visits and through media channels.
Epidaure Market–Effectiveness and transferability of a school-based intervention to improve healthy and sustainable food choices by schoolchildren: Protocol of a randomized controlled trial and qualitative study
Authors: Curnier Aurélie , Cholley-Gomez Marie , Lecêtre Florian , Peteuil Audrey , Meunier-Beillard Nicolas , Fonquerne Leslie , Darras Lucy , Eymard-Duvernay Sabrina , Méjean Caroline , Delpierre Cyrille , Cottet Vanessa , Cousson-Gélie Florence 
Published: July 2024

Context
At least 40% of cancers are linked to environmental or behavioral factors, and dietary behavior appears to be a major lever. Epidaure Market is a prevention initiative developed using a method for co-constructing health promotion initiatives and prevention programs that stratifies evidence from the scientific literature and combines it with experiential knowledge (DEVA, TPB, BCT). It promotes a sustainable diet (i.e., healthy, ecological and ethical nutrition) among 5th and 4th grade students during the crucial period of adolescence, when these behaviors are often far from the recommendations.

Method
The protocol implemented was carried out in 72 middle school classes in the Montpellier and Dijon academies. The intervention included teaching sessions and a virtual supermarket game, integrated into the school curriculum and delivered by science teachers. Effectiveness is tested in a cluster randomized controlled trial with 3 evaluation times (pre- and post-intervention and 1 follow-up). The study also includes an implementation assessment, with process analysis and implementation elements, as well as a transferability assessment based on key functions (FIC model and Astaire grid).

Expected outcomes
The study is still underway within the school. The primary expected outcome is a positive influence on the motives underlying food choices to move towards a sustainable diet. Secondary expectations involve changes in variables such as self-efficacy and perceived social norms, as well as an increase in knowledge about healthy eating. We also expect the qualitative approaches to provide information on the deployment process in the new territories.

Discussion
The study aims not only to demonstrate the effectiveness of Epidaure Market, but also to identify the optimal conditions for its nationwide implementation in France’s middle schools. Ultimately, the initiative aims to help reduce the incidence of cancer by promoting healthier eating habits among teenagers.