bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐relay selection schemes based on evolutionary algorithm in cooperative relay networks
Authors: Cao Jinlong , Zhang Tiankui , Zeng Zhimin , Chen Yue , Chai Kok Keong 
Published: December 2013

SUMMARYIn cooperative relay networks, the selected relay nodes have great impact on the system performance. In this paper, a multi‐relay selection schemes that consider both single objective and multi‐objective are proposed based on evolutionary algorithms. First, the single‐objective optimization problems of the best cooperative relay nodes selection for signal‐to‐noise ratio (SNR) maximization or power efficiency optimization are solved based on the quantum particle swarm optimization (QPSO). Then the multi‐objective optimization problems of the best cooperative relay nodes selection for SNR maximization and power consumption minimization (two contradictive objectives) or SNR maximization and power efficiency optimization (also two contradictive objectives) are solved based on a non‐dominated sorting QPSO, which can obtain the Pareto front solutions of the problems considering two contradictive objectives simultaneously. The relay systems can select one solution from the Pareto front solutions according to the trade‐off of SNR and power consumption (or the trade‐off of SNR and power efficiency) to take part in the cooperative transmission. Simulation results show that the QPSO‐based multi‐relay selection schemes have the ability to search global optimal solution compared with other multi‐relay selection schemes in literature. Simulation results also show that the non‐dominated sorting QPSO‐based multi‐relay selection schemes obtain the same Pareto solutions as exhaustive search, but the proposed schemes have a very low complexity. Copyright © 2013 John Wiley & Sons, Ltd.
Heart rate variability is severely impaired among type 2 diabetic patients with hypertension
Authors: Istenes Ildikó , Körei Anna Erzsébet , Putz Zsuzsanna , Németh Nóra , Martos Timea , Keresztes Katalin , Kempler Miklós Soma , Erzsébet Vági Orsolya , Vargha Péter , Kempler Péter 
Published: December 2013

AbstractIntroductionThe aim of our study was to evaluate the relative effect of diabetes and hypertension on heart rate variability.Research design and methodsFour age‐matched groups including type 2 diabetic patients with and without hypertension, non‐diabetic patients with essential hypertension and healthy control subjects were studied. Autonomic function was evaluated by the standard cardiovascular reflex tests and 24‐hour heart rate variability measurement. Heart rate variability was characterized by the triangular index value and by the spectral components of the frequency domain analysis.ResultsAccording to the two‐way analysis of variance on ranks, all parameters were influenced negatively by diabetes (heart rate variability triangular index: p < 0.001; low‐frequency component: p < 0.0001; high‐frequency component: p < 0.001; and total power: p < 0.0001), whereas hypertension had a negative effect only on the low‐frequency component (p < 0.05). The interaction between hypertension and diabetes was not significant, indicating that their effects on the heart rate variability parameters are additive. Beat‐to‐beat variation upon deep breathing, the most sensitive cardiovascular reflex test was also negatively influenced by both diabetes (p < 0.001) and hypertension, (p < 0.05), and their effects were additive.ConclusionsDiabetes appears to have a greater effect on autonomic dysfunction compared with hypertension. Patients suffering from both diabetes and hypertension are at the highest risk of reduced heart rate variability. Early assessment of the autonomic nerve function is suggested in diabetic patients with hypertension. Copyright © 2013 John Wiley & Sons, Ltd.
Assessment of fracture risk by the FRAX algorithm in men and women with and without type 2 diabetes mellitus: a cross‐sectional study
Authors: Carnevale Vincenzo , Morano Susanna , Fontana Andrea , Annese Maria Antonietta , Fallarino Mara , Filardi Tiziana , Copetti Massimiliano , Pellegrini Fabio , Romagnoli Elisabetta , Eller‐Vainicher Cristina , Zhukouskaya Volha V. , Chiodini Iacopo , D'Amico Graziella 
Published: December 2013

AbstractBackgroundThe FRAX algorithm is a diffuse tool to assess fracture risk, but it has not been clinically applied in European patients with diabetes. We investigated FRAX‐estimated fracture risk in patients with type 2 diabetes mellitus (DM), compared with concomitantly enrolled control subjects.MethodsIn our multicentric cross‐sectional study, we assessed the FRAX scores of 974 DM and 777 control subjects from three Italian diabetes outpatient clinics, and in DM. We tested the association between parameters and complications of the disease and FRAX scores.ResultsDM had significantly lower FRAX‐estimated probability of both major osteoporotic fracture (MOF) and hip fracture (HF) than control subjects (6.35 ± 5.07% versus 7.75 ± 6.93%, p < 0.001, and 2.17 ± 3.07% versus 2.91 ± 4.56%, p = 0.023, respectively). When grouping by gender, such differences were found only in men. In DM, the frequency of previous fracture was higher than in control subjects (29.88% versus 20.46%, p < 0.001). In diabetic patients, age, sex, body mass index, HbA1c and hypoglycaemia are significantly associated with FRAX scores; gender‐specific regression models differed.Among DM, the tree‐based regression (classification and regression tree (CART)) analysis identified groups of patients with different mean FRAX scores. In female DM aged >65 years with or without obesity, MOF > 20% was found in 5.66% and 13.53% and HF > 3% in 40.57% and 63.91% of patients, respectively.ConclusionsPatients with DM had mean FRAX scores lower than control subjects, despite the higher number of previous fractures. Some features and complications of DM did associate with FRAX scores. Among DM patients, the CART analysis identified subgroups with higher FRAX scores. However, despite its potential utility, concerns still remain for using FRAX in DM patients. Copyright © 2013 John Wiley & Sons, Ltd.
Methods for olfactory fMRI studies: Implication of respiration
Authors: Wang Jianli , Sun Xiaoyu , Yang Qing X. 
Published: December 2013

AbstractHuman olfactory system is under‐studied using fMRI compared with other sensory systems. Because the perception (intensity, threshold, and valence) and detection of odors are tightly involved with respiration, the subject's respiration pattern modulates and interacts with the experimental paradigm, which presents difficulties for olfactory fMRI data acquisition, post‐processing, and interpretation. Based on our investigation on the interactions of odor presentation and subject's respiration, we propose a respiration‐triggered event‐related olfactory fMRI technique and a data post‐processing method that effectively captures precise onsets of olfactory blood‐oxygen‐level‐dependent (BOLD) signal in the primary olfactory cortex. We compared the olfactory BOLD signals from seventeen normal healthy adults with diverse respiratory patterns and showed that the subjects' respiratory patterns modulated the olfactory stimulation paradigm, which significantly confounded the BOLD signal. The presented experimental technique provides a simple and effective means for generating reliable olfactory fMRI results. Hum Brain Mapp 35:3616–3624, 2014. © 2013 Wiley Periodicals, Inc.
Brentuximab vedotin followed by allogeneic transplantation as salvage regimen in patients with relapsed and/or refractory Hodgkin's lymphoma
Authors: Garciaz Sylvain , Coso Diane , Peyrade Frederic , Fürst Sabine , Duran Ségolène , Chetaille Bruno , Brenot‐Rossi Isabelle , Devillier Raynier , Granata Angela , Blaise Didier , Bouabdallah Réda 
Published: December 2013

AbstractPatients with relapsed or refractory Hodgkin lymphoma (RR‐HL) have poor outcomes. Brentuximab vedotin (BV), an antibody–drug conjugate comprising an anti‐CD30 antibody conjugated to the potent anti‐microtubule agent, monomethyl auristatin E, induces high tumour responses with moderate adverse effects. In a retrospective study, we describe objective response rates and subsequent allogeneic stem cell transplantation (allo‐SCT) in patients with RR‐HL treated by BV in a named patient program in two French institutions. Twenty‐four adult patients with histologically proven CD30+ RR‐HL treated with BV were included from July 2009 to November 2012. Response to BV treatment was evaluated after four cycles. Eleven patients were in complete response (45.8%), while five patients were in partial response (20.8%), with an overall response rate of 66.6%. Eight patients failed to respond to BV (33.3%). All of the responding patients could receive consolidation treatment after BV: three patients underwent autologous stem cell transplantation (auto‐SCT), three patients received a tandem auto‐SCT/allo‐SCT, nine patients received allo‐SCT and one patient was treated with donor lymphocyte infusion. We found no treatment‐related mortality at day 100 among the 12 patients who underwent BV following by allogeneic transplantation. With a median follow‐up of 20 months (range 10.5–43.2), none of them relapsed or died. BV followed by allo‐SCT represents an effective salvage regimen in patients with RR‐HL. Copyright © 2013 John Wiley & Sons, Ltd.
Satisfaction with the level and type of resource use of a health insurance scheme in Nigeria: health management organizations' perspectives
Authors: Mohammed Shafiu , Souares Aurelia , Lorenzo Bermejo Justo , Babale Sufiyan Muawiyyah , Sauerborn Rainer , Dong Hengjin 
Published: December 2013

ABSTRACTSome developing countries have incorporated managed care elements into their national health insurance schemes. In practice, hybrid health management organizations (Hmos) are insurers who, bearing some resemblance to managed care in the USA, are vertically integrated in the scheme's revenue collection and pool and purchase healthcare services within a competitive framework. To date, few studies have focused on these organizations and their level of satisfaction with the scheme's optimal‐resource‐use (ORU) implementation. In Nigeria, the study site, Hmos were categorized on the basis of their satisfaction with ORU activities. One hundred forty‐seven Hmo staff were randomly interviewed. The types of ORU domain categories were provider payment mechanism, administrative efficiency, benefit package inclusions and active monitoring mechanism. Bivariate analysis was used to determine differences among the Hmos' satisfaction with the various ORU domains. The Hmos' satisfaction with the health insurance scheme's ORU activities was 59.2% generally, and the associated factors were identified. According to the Hmos' perspectives related to the type of ORU, the fee‐for‐service payment method and regular inspection performed weakly. Hmos' limited satisfaction with the scheme's ORU raises concerns regarding ineffectiveness that may hinder implementation. To offset high risks in the scheme, it appears necessary for the regulatory agency to adapt and reform strategies of provider payment and active monitoring mechanisms according to stakeholder needs. Our findings further reveal that having Hmos evaluate ORU is useful for providing evidence‐based information for policy making and regulatory utilization related to implementation of the health insurance scheme. Copyright © 2013 John Wiley & Sons, Ltd.
ORSADEM: A ONE‐DIMENSIONAL SHALLOW WATER CODE FOR FLOOD INUNDATION MODELLING
Authors: Petaccia Gabriella , Natale Elisabetta 
Published: December 2013

ABSTRACTThis paper describes the ORSADEM software, which solves one‐dimensional (1‐D) shallow water equations written in conservative form by numerical schemes suitable for the modelling of shocks and discontinuities generated by a dam break. Unlike the majority of commercial software, ORSADEM automatically defines the model cross‐sections based on the terrain digital elevation model (DEM) and automatically maps the flood‐prone areas, solving the hydraulic equations. The flooded area is mapped using a new method congruent with the unidimensionality of the model. ORSADEM does not need any external platforms. The software has been developed by researchers of the Department of Civil and Architectural Engineering at the University of Pavia and it is presented here applied to the case study of the Brembo River. Copyright © 2013 John Wiley & Sons, Ltd.
COMPARING A LARGE‐SCALE DEM‐BASED FLOODPLAIN DELINEATION ALGORITHM WITH STANDARD FLOOD MAPS: THE TIBER RIVER BASIN CASE STUDY
Authors: Nardi Fernando , Biscarini Chiara , Di Francesco Silvia , Manciola Piergiorgio , Ubertini Lucio 
Published: December 2013

ABSTRACTA large‐scale floodplain delineation algorithm is applied to identify potentially inundated areas at the basin scale. The model, which mainly uses a digital elevation model (DEM) and design flood peak discharge at the outlet as input data, is implemented within a geographic information system (GIS). It implements a preliminary GIS‐based terrain analysis framework for estimating the stream network, surface flow direction and drainage grids, while the core algorithm implements an automated fluvial cross‐section extraction for discharge and flow height estimation. The delineation is then implemented by filtering the floodplain cells as those cells whose elevation is lower than the corresponding channel flow height. The proposed ‘hydrogeomorphic floodplain’, obtained on the Tiber River basin (approx. 17 000 km2) using the global NASA Shuttle Radar Topography Mission (SRTM) DEM at 90 m resolution, is compared to the official flood maps of the Tiber River Basin Authority to evaluate the model behaviour with respect to standard flood mapping results. The presented case study shows the potential of using an automated GIS algorithm and largely available remotely sensed data for the preliminary identification of the floodplain footprint at the global scale. Copyright © 2013 John Wiley & Sons, Ltd.
Mechanisms of Phenytoin‐Induced Toxicity in Freshly Isolated Rat Hepatocytes and the Protective Effects of Taurine and/or Melatonin
Authors: Eghbal Mohammad Ali , Taziki Shohreh , Sattari Mohammad Reza 
Published: December 2013

ABSTRACTPhenytoin is a widely used antiepileptic drug. However, hepatotoxicity is one of its adverse effects reported in some patients. The mechanism(s) by which phenytoin causes hepatotoxicity is not clear yet. This study was designed to evaluate the cytotoxic mechanism(s) of phenytoin toward rat hepatocytes (whose cytochrome P450 enzymes had been induced by Phenobarbital). Furthermore, the effect of taurine and/or melatonin on this toxicity was investigated. Cell death, reactive oxygen species (ROS) formation, lipid peroxidation (LPO), and mitochondrial depolarization were monitored as toxicity markers. Results showed that phenytoin caused an elevation in ROS formation, depletion of intracellular reduced glutathione, increase in cellular oxidized glutathione, enhancement of LPO, and mitochondrial damage. Taurine (1 mM) and/or melatonin (1 mM) administration decreased the intensity of cellular injury caused by phenytoin. This study suggests the protective role of taurine and/or melatonin against phenytoin‐induced cellular damage probably through their reactive radical scavenging properties and their effects on mitochondria.
Ultrasonographic findings of gonarthritis caused by toothpick: A case report
Authors: Tang Yuanjiao , Zhu Meng , Qiu Li 
Published: December 2013

ABSTRACTWe report a rare case of a 5‐year‐old patient with a toothpick in the knee joint resulting in septic arthritis. The toothpick was detected in the joint by sonography and was confirmed at surgery. A wooden foreign body is an uncommon cause of arthritis. This case report is followed by a discussion of the value of sonography in the diagnosis of wooden foreign‐body arthritis. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound 42:379–381, 2014
Three‐dimensional volumetric quantification of fat loss following cryolipolysis
Authors: Garibyan Lilit , Sipprell William H. , Jalian H. Ray , Sakamoto Fernanda H. , Avram Mathew , Anderson R. Rox 
Published: December 2013

Background and ObjectivesCryolipolysis is a noninvasive and well‐tolerated treatment for reduction of localized subcutaneous fat. Although several studies demonstrate the safety and efficacy of this procedure, volumetric fat reduction from this treatment has not been quantified. This prospective study investigated the change in volume of fat after cryolipolysis treatment using three‐dimensional (3D) photography.Materials and MethodsA prospective study of subjects treated with cryolipolysis on the flank (love handle) was performed at Massachusetts General Hospital. Volume measurements were performed with a Canfield Scientific Vectra three‐dimensional camera and software to evaluate the amount of post procedure volume change. Clinical outcomes were assessed with caliper measurements, subject surveys, and blinded physician assessment of photographs.ResultsEleven subjects were enrolled in this study. Each subject underwent a single cycle of cryolipolysis to one flank. The untreated flank served as an internal control. The follow‐up time after treatment was 2 months. The mean amount of calculated absolute fat volume loss using 3D photography from baseline to 2 months follow‐up visit was 56.2 ± 25.6 from the treatment site and 16.6 ± 17.6 cc from the control (P < 0.0001). A mean absolute difference of 39.6 cc between the treated and untreated sides was calculated at 2 months post‐treatment. Comparison of caliper measurements from baseline to 2 months post‐treatment demonstrated significant reduction of the treated flank from 45.6 ± 5.8 mm at baseline to 38.6 ± 4.6 mm at 2 months post‐treatment (P < 0.001). The untreated flank did not show significant reduction with caliper measurements demonstrating 45.3 ± 5.0 mm at baseline and 44.6 ± 5.1 mm at 2 months post‐treatment (P = 0.360). No unexpected side effects or adverse events were reported. Post‐treatment satisfaction surveys demonstrated 82% of subjects were satisfied with the results.ConclusionsCryolipolysis is a safe, well‐tolerated, and effective noninvasive fat removal methodology that on average leads to 39.6 cc of fat loss of the treated flank at 2 months after a single treatment cycle. Lasers Surg. Med. 46:75–80, 2014. © 2013 Wiley Periodicals, Inc.
Deciphering intrafamilial phenotypic variability by exome sequencing in a Bardet–Biedl family
Authors: González‐del Pozo María , Méndez‐Vidal Cristina , Santoyo‐Lopez Javier , Vela‐Boza Alicia , Bravo‐Gil Nereida , Rueda Antonio , García‐Alonso Luz , Vázquez‐Marouschek Carmen , Dopazo Joaquín , Borrego Salud , Antiñolo Guillermo 
Published: December 2013

AbstractBardet–Biedl syndrome (BBS) is a model ciliopathy characterized by a wide range of clinical variability. The heterogeneity of this condition is reflected in the number of underlying gene defects and the epistatic interactions between the proteins encoded. BBS is generally inherited in an autosomal recessive trait. However, in some families, mutations across different loci interact to modulate the expressivity of the phenotype. In order to investigate the magnitude of epistasis in one BBS family with remarkable intrafamilial phenotypic variability, we designed an exome sequencing–based approach using SOLID 5500xl platform. This strategy allowed the reliable detection of the primary causal mutations in our family consisting of two novel compound heterozygous mutations in McKusick–Kaufman syndrome (MKKS) gene (p.D90G and p.V396F). Additionally, exome sequencing enabled the detection of one novel heterozygous NPHP4 variant which is predicted to activate a cryptic acceptor splice site and is only present in the most severely affected patient. Here, we provide an exome sequencing analysis of a BBS family and show the potential utility of this tool, in combination with network analysis, to detect disease‐causing mutations and second‐site modifiers. Our data demonstrate how next‐generation sequencing (NGS) can facilitate the dissection of epistatic phenomena, and shed light on the genetic basis of phenotypic variability.
Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene
Authors: Poulsen Ebbe Toftgaard , Runager Kasper , Risør Michael W. , Dyrlund Thomas F. , Scavenius Carsten , Karring Henrik , Praetorius Jeppe , Vorum Henrik , Otzen Daniel E. , Klintworth Gordon K. , Enghild Jan J. 
Published: December 2013

PurposeIn this study, we investigated whether the phenotypic difference observed between two lattice corneal dystrophy type 1 (LCD type 1) cases caused by either a single A546D substitution or an A546D/P551Q double substitution in TGFBIp (transforming growth factor beta induced protein) can be ascribed to (i) a difference in the proteomes of corneal amyloid deposits, (ii) altered proteolysis of TGFBIp, or (iii) structural changes of TGFBIp introduced by the P551Q amino acid substitution.Experimental designAmyloid deposits were isolated from the corneas of two siblings with LCD type 1 resulting from A546D/P551Q mutations in the TGFBI gene using laser capture microdissection and subsequently analyzed by LC‐MS/MS. Proteolytic processing of TGFBIp was addressed by counting peptide spectra. Lastly, to study the possible effect of the P551Q substitution, recombinant FAS1–4 domain variants were subjected to in vitro stability assays.ResultsThe amyloid proteomes and TGFBIp processing of the two A546D/P551Q LCD type 1 cases were similar to each other as well as to the A546D amyloid proteome previously reported by us. The stability assays revealed a minor destabilization of the FAS1–4 domain upon the addition of the P551Q mutation, moreover, it resulted in different accessibility to tryptic cleavage sites between the A546D and A546D/P551Q mutant FAS1–4 domain variants.Conclusion and clinical relevanceThe difference in A546D and A546D/P551Q LCD type 1 phenotypes cannot be ascribed to altered corneal amyloid composition or altered in vivo proteolytic processing of TGFBIp. Instead, a small difference in thermodynamic stability introduced by the P551Q mutation most likely causes structural changes of TGFBIp. The MS proteomics data have been deposited to the ProteomeXchange with identifier PXD000307 (http://proteomecentral.proteomexchange.org/dataset/PXD000307).