bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint relay antenna and precoding selection for K‐user MIMO Y channels with physical‐layer network coding
Authors: Wang Fanzhao , Song Qingyang , Ning Zhaolong , Zhou Lining 
Published: September 2015

SummaryIn this paper, we focus on physical‐layer network coding (PNC) used in multiple‐input multiple‐output (MIMO) Y channels, where K users simultaneously exchange messages with each other via a shared relay. For MIMO‐PNC, signal space alignment for network coding (SSA‐NC) is a promising precoding method and can achieve K(K‐1) degrees of freedom if certain conditions can be satisfied. An important one is that the number of relay antennas is less than twice of the user antennas, that is, the dimensionality constraint of SSA‐NC. In this paper, we focus on a particular scenario where the dimensionality constraint is not satisfied. In order to resolve this problem, we develop a scheme of jointly selecting relay antennas and precoding vectors. In particular, a novel precoding and detection method is presented to alleviate the interference caused by simultaneous transmissions. Through analyzing the symbol error rate performance of MIMO‐PNC, we establish the relationship between the achievable flow diversity gain and the optimal number of the antennas, and a precoding selection method is designed under a given relay antenna configuration. Finally, we propose a joint scheme to select the optimal relay antenna configuration and precoding vectors. Numerical results demonstrate that the presented scheme can effectively support MIMO‐PNC in various scenarios. Copyright © 2015 John Wiley & Sons, Ltd.
Solid State Electrochemical Oxidation of Some Bisphosphoramidates in Aqueous Media and their Applications in DNA Sensing
Authors: Gholivand Mohammad Bagher , Mohammadi‐Behzad Leila , Paimard Giti , Gholivand Khodayar , Gholami Akram 
Published: September 2015

AbstractBisphosphoramidates are known as anticancer, antibacterial, antiviral drugs and enzyme inhibitory agents. These compounds are electroactive and insoluble in aqueous media. Hence, a comprehensive study about the electrochemical properties of them seems very interesting. The oxidative behaviors of some bisphosphoramidates were studied in buffer solution over a wide pH range by cyclic voltammetry and differential pulse voltammetry using spiked carbon paste electrodes. The interaction of these compounds with calf thymus DNA (CT‐DNA) showed the ability of these compounds as DNA sensing. The decrease in the anodic peaks of bisphosphoramidates in the presence of DNA was used for the DNA monitoring.
Use of transoral nasopharyngeal brush biopsy for Epstein–Barr virus DNA detection of local recurrence of nasopharyngeal carcinoma after radiotherapy
Authors: Lam Jacky Wai‐Kei , Chan Jimmy Yu‐Wai , Ho Wai‐Kuen , Tsang Raymond King‐Yin 
Published: September 2015

AbstractBackgroundThe purpose of this study was to evaluate the use of transoral nasopharyngeal brush biopsies and quantitative polymerase chain reaction (qPCR) Epstein–Barr virus (EBV) DNA detection system in surveillance of local recurrence of nasopharyngeal carcinoma (NPC).MethodsA prospective cohort study was performed to compare the nasopharyngeal epithelial EBV DNA levels of patients with recurrent NPC and the control group of postirradiated patients with NPC disease in remission.ResultsFourteen patients with recurrent NPC and 15 postirradiated patients in disease remission were recruited for transoral brush biopsies. There was a statistically significant difference between the mean EBV detection level (EDL) of the recurrence group (EDL = 2.38) and the control group (EDL = 0.17; p < .0001). There was no significant correlation between the EDL and the recurrence of T classification disease.ConclusionThe transoral brush biopsy and qPCR EBV DNA detection system may provide an additional surveillance strategy for recurrence of NPC. Further study is required to validate its sensitivity, specificity, and cost‐effectiveness. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1301–E1304, 2016
Improving the 18F‐fluoromethylcholine (18F‐FCH) radiochemical yield via optimising the azeotropic drying of non‐carrier‐added 18F‐fluorine
Authors: Hassan Hishar , Abu Bakar Suharzelim , Che A. Halim Khairul Najah , Idris Jaleezah , Ahmad Saad Fathinul Fikri , Nordin Abdul Jalil 
Published: September 2015

Abstract18F‐Fluoromethylcholine (18F‐FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in PET/CT examination. Nevertheless, it has never been synthesised in Malaysia. We acknowledged the major problem with 18F‐FCH is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this technical note presents improved 18F‐FCH radiochemical yields after carrying out optimisation on azeotropic drying of non‐carrier‐added 18F‐Fluorine.
CREBBP and EP300 mutational spectrum and clinical presentations in a cohort of Swedish patients with Rubinstein–Taybi syndrome
Authors: Wincent Josephine , Luthman Aron , van Belzen Martine , van der Lans Christian , Albert Johanna , Nordgren Ann , Anderlid Britt‐Marie 
Published: September 2015

AbstractRubinstein–Taybi syndrome (RTS) is a rare autosomal dominant congenital disorder characterized by distinctive facial features, broad thumbs and halluces, growth retardation, and a variable degree of cognitive impairment. CREBBP is the major causative gene and mutations in EP300 are the cause of RTS in a minority of patients. In this study, 17 patients with a clinical diagnosis of RTS were investigated with direct sequencing, MLPA, and array‐CGH in search for mutations in these two genes. Eleven patients (64.7%) had disease‐causing point mutations or a deletion in CREBBP and in one patient (5.9%) a causal de novo frameshift mutation in EP300 was identified. This patient had broad thumbs, mild intellectual disability, and autism. In addition, an inherited missense mutation of uncertain clinical significance was identified in EP300 in one patient and his healthy father, and three patients had intronic nucleotide changes of uncertain clinical significance in CREBBP. Snoring and sleep apnea were common in both groups and four of the patients' mothers had preeclampsia during pregnancy. Importantly, difficulties associated with anesthesia were frequently reported and included delayed or complicated emergency in 53.3% of patients.
Maternal cardiac adaptation to subsequent pregnancy in formerly pre‐eclamptic women according to recurrence of pre‐eclampsia
Authors: Ghossein‐Doha C. , Spaanderman M. E. A. , Al Doulah R. , Van Kuijk S. M. , Peeters L. L. H. 
Published: September 2015

ABSTRACTObjectivesLeft‐ventricular remodeling in women with pre‐eclampsia (PE) is concentric rather than eccentric, and tends to persist postpartum, particularly after early‐onsetPE. This study was designed to determine whether prepregnancy cardiac geometry and function along with cardiac adaptation to the subsequent pregnancy in former early‐onsetPEpatients differs between those who do and those who do not develop recurrentPElater on in their second pregnancy.MethodsIn 51 women with a history of early‐onsetPE, we performed serial cardiac ultrasound examinations and recorded automated measurements of blood pressure/heart rate before pregnancy and again at three consecutive times in the first half of their subsequent pregnancy. From the hospital records, we retrieved information on pregnancy outcome. We compared intergroup differences in cardiac indices using independent samplest‐test, and intergroup differences in prepregnant cardiac ultrasound indices and subsequent pregnancy‐induced cardiac adaptive response using repeated‐measuresANOVA.ResultsPErecurred in 14/51 (27%) women. Preconception, the recurrent‐PEgroup differed from the non‐recurrent‐PEgroup by having a lower left‐ventricular mass (LVM) index (28vs32 g/m2.7,P < 0.05) and stroke volume (68vs77 mL,P < 0.05), and a higher resting heart rate (71vs64 bpm,P < 0.05). Despite these prepregnancy differences, the pregnancy‐induced pattern of cardiac adaptive response was comparable in the two subgroups. After excluding hypertensive women, prepregnancy values for theLVMindex remained significantly lower in the recurrent‐PEgroup.ConclusionsWomen with recurrentPEdiffered from the non‐recurrent‐PEgroup by having a lowerLVMindex and stroke volume, and a higher heart rate, but they responded to their subsequent pregnancy with a similar pattern of cardiac adaptation. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.
Spatial Distribution of Benthic Foraminifera in the Palar Estuary, Tamil Nadu
Authors: Nagendra R. , Sathiyamoorthy P. , Reddy A. Nallapa , Ramachandran A. 
Published: September 2015

Abstract:
Spatial variability of estuarine benthic foraminiferal assemblages in the surface (0-1cm) sediments has been determined for the Palar river estuary, Tamil Nadu. Twelve bottom water and sediment grab samples were collected at different water depths in the estuarine zone to determine the ecological relationship of benthic foraminiferal assemblages with physicochemical characteristics. The water analyses revealed that hypo saline, high dissolved oxygen and low pH conditions were prevailing at water-substrate interface at the time of sampling. The study indicated that salinity, pH and substrate have a patchy linear relationship with living and total faunal frequency but individual species Ammonia beccarii, A. tepida and A. parkinsoniana showed positive linear correlation with salinity and dissolved oxygen values. The restricted connectivity of the estuary with Bay of Bengal and frequent anthropogenic activity appeared to have an adverse effect on the faunal abundance, diversity and spatial distribution. The Q mode cluster analysis based on single linkage approach was performed to determine if any groups of samples or species correlated with ambient environmental factors. The study identified a total of 36 benthic foraminifer species belonging to 3 sub-orders. The faunal assemblages were dominated by two species Ammonia parkinsoniana and A.beccarii nearly at all the sampling stations.
High Resolution Seismic Reflection Studies in Godavari Coal Fields: Mapping of Coal Seams and Associated Structural Features
Authors: Prasad P. Prabhakara , Dhanam K. , Pavan Kishore P. , Mysaiah D. , Seshunarayana T. 
Published: September 2015

Abstract
High Resolution seismic Reflection technique is one of the most suitable geophysical methods for mapping the shallow coal seams and associated structural features, which will provide essential input for adopting proper methodology for exploitation and mine planning of coal reserves. In the present study, depth of the coal horizons were determined and the geometry of the faults in Ramagundam area, Gondwana basin is illustrated which is located at the junction of the Bastar and Dharwar cratons. The High Resolution seismic surveys conducted along eight parallel profiles with coverage of surface area one km2 in the study region. The study reveals (1) seismic sections up to 1000m depth with thick, gently dipping Barakar Formation, (2) thick coal horizons at a depth range of 200 to 500m, and (3) NW-SE striking and gently dipping normal faults are observed in coal horizons. The obtained results will provide better knowledge of the coal reserves in the study area.
Development of a Geomorphological Erosion Index for Shakkar Watershed
Authors: Gajbhiye Sarita , Sharma S. K. , Tignath S. 
Published: September 2015

Abstract
Geomorphological parameters directly or indirectly reflect almost entire watershed based causative factors affecting runoff and sediment loss/soil erosion. So, in the absence of sufficient hydrological data morphometric parameters along with satellite based land use/ land cover information of watershed may be helpful in prioritizing the sub-watersheds. Keeping these aspects in view, it was planned to develop a geomorphological index in the Shakkar river catchment of Upper Narmada Basin, India, The objective of the present study is to develop the Geomorphological Index using Principal Component Analysis on the morphometric parameters derived from the Geographic Information System (GIS) environment, which can be used by the field investigators and modeler's in assessing the soil erosion. As an outcome of the analysis, the geomorphological index synthesizes the status of the three morphometric parameters i.e. drainage frequency (Fs), form factor (Rr) and bifurcation ratio (Rb) into a single indicator of geomorphological index. The Geomorphological Index (GI) for the study area found to vary from 3.64 to 21.63. The implementation of geomorphological index may provide the guiding data for sustainable water-resources management in Shakkar river watershed.
11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test
Authors: Slattery David A. , Uzunov Doncho P. , Cryan John F. 
Published: September 2015

Objective11β-dehydroxysteroid dehydrogenase (HSD) types 1 and 2, enzymes are involved in the activation and inactivation of glucocorticoids in vivo, respectively. Indirect evidence implicates two enzymes in the aetiology of depression but no study has directly assessed the potential role of 11 β-HSD1 in animal tests.MethodsWe assessed 11 β-HSD1 knockout mice in the forced swim test (FST), tail suspension test (TST) and for locomotor activity.ResultsGenetic ablation of the 11β-HSD1 gene results in an antidepressant-like phenotype in the FST; the most widely utilised animal test of antidepressant activity, but not in the related TST. This may be related to the different biological substrates underlying these tests. The decreased FST immobility was not due to alterations in general activity.ConclusionsTaken together these results suggest that 11β-HSD1 may play an important role in depression-related behaviours and further studies are necessary to fully characterise its role in such behaviour.
Hyper-Fit: Fitting Linear Models to Multidimensional Data with Multivariate Gaussian Uncertainties
Authors: Robotham A. S. G. , Obreschkow D. 
Published: September 2015

AbstractAstronomical data is often uncertain with errors that are heteroscedastic (different for each data point) and covariant between different dimensions. Assuming that a set of D-dimensional data points can be described by a (D − 1)-dimensional plane with intrinsic scatter, we derive the general likelihood function to be maximised to recover the best fitting model. Alongside the mathematical description, we also release the hyper-fit package for the R statistical language (github.com/asgr/hyper.fit) and a user-friendly web interface for online fitting (hyperfit.icrar.org). The hyper-fit package offers access to a large number of fitting routines, includes visualisation tools, and is fully documented in an extensive user manual. Most of the hyper-fit functionality is accessible via the web interface. In this paper, we include applications to toy examples and to real astronomical data from the literature: the mass-size, Tully–Fisher, Fundamental Plane, and mass-spin-morphology relations. In most cases, the hyper-fit solutions are in good agreement with published values, but uncover more information regarding the fitted model.
Temporal changes in growth, condition and trophic niche in juvenile Cyprinus carpio infected with a non-native parasite
Authors: PEGG J. , ANDREOU D. , WILLIAMS C. F. , BRITTON J. R. 
Published: September 2015

SUMMARYIn host–parasite relationships, parasite prevalence and abundance can vary over time, potentially impacting how hosts are affected by infection. Here, the pathology, growth, condition and diet of a juvenile Cyprinus carpio cohort infected with the non-native cestode Bothriocephalus acheilognathi was measured in October 2012 (end of their first summer of life), April 2013 (end of first winter) and October 2013 (end of second summer). Pathology revealed consistent impacts, including severe compression and architectural modification of the intestine. At the end of the first summer, there was no difference in lengths and condition of the infected and uninfected fish. However, at the end of the winter period, the condition of infected fish was significantly reduced and by the end of their second summer, the infected fish were significantly smaller and remained in significantly reduced condition. Their diets were significantly different over time; infected fish consumed significantly higher proportions of food items <53 µm than uninfected individuals, a likely consequence of impaired functional traits due to infection. Thus, the sub-lethal impacts of this parasite, namely changes in histopathology, growth and trophic niche were dependent on time and/or age of the fish.
Leveraging existing data sets to generate new insights into Alzheimer’s disease biology in specific patient subsets
Authors: Fowler Kevin D. , Funt Jason M. , Artyomov Maxim N. , Zeskind Benjamin , Kolitz Sarah E. , Towfic Fadi 
Published: September 2015

AbstractTo generate new insights into the biology of Alzheimer’s Disease (AD), we developed methods to combine and reuse a wide variety of existing data sets in new ways. We first identified genes consistently associated with AD in each of four separate expression studies and confirmed this result using a fifth study. We next developed algorithms to search hundreds of thousands of Gene Expression Omnibus (GEO) data sets, identifying a link between an AD-associated gene (NEUROD6) and gender. We therefore stratified patients by gender along with APOE4 status and analyzed multiple SNP data sets to identify variants associated with AD. SNPs in either the region of NEUROD6 or SNAP25 were significantly associated with AD, in APOE4+ females and APOE4+ males, respectively. We developed algorithms to search Connectivity Map (CMAP) data for medicines that modulate AD-associated genes, identifying hypotheses that warrant further investigation for treating specific AD patient subsets. In contrast to other methods, this approach focused on integrating multiple gene expression datasets across platforms in order to achieve a robust intersection of disease-affected genes and then leveraging these results in combination with genetic studies in order to prioritize potential genes for targeted therapy.
Planting increases the abundance and structure complexity of soil core functional genes relevant to carbon and nitrogen cycling
Authors: Wang Feng , Liang Yuting , Jiang Yuji , Yang Yunfeng , Xue Kai , Xiong Jinbo , Zhou Jizhong , Sun Bo 
Published: September 2015

AbstractPlants have an important impact on soil microbial communities and their functions. However, how plants determine the microbial composition and network interactions is still poorly understood. During a four-year field experiment, we investigated the functional gene composition of three types of soils (Phaeozem, Cambisols and Acrisol) under maize planting and bare fallow regimes located in cold temperate, warm temperate and subtropical regions, respectively. The core genes were identified using high-throughput functional gene microarray (GeoChip 3.0) and functional molecular ecological networks (fMENs) were subsequently developed with the random matrix theory (RMT)-based conceptual framework. Our results demonstrated that planting significantly (P < 0.05) increased the gene alpha-diversity in terms of richness and Shannon – Simpson’s indexes for all three types of soils and 83.5% of microbial alpha-diversity can be explained by the plant factor. Moreover, planting had significant impacts on the microbial community structure and the network interactions of the microbial communities. The calculated network complexity was higher under maize planting than under bare fallow regimes. The increase of the functional genes led to an increase in both soil respiration and nitrification potential with maize planting, indicating that changes in the soil microbial communities and network interactions influenced ecological functioning.
Analyzing animal behavior via classifying each video frame using convolutional neural networks
Authors: Stern Ulrich , He Ruo , Yang Chung-Hui 
Published: September 2015

AbstractHigh-throughput analysis of animal behavior requires software to analyze videos. Such software analyzes each frame individually, detecting animals’ body parts. But the image analysis rarely attempts to recognize “behavioral states”—e.g., actions or facial expressions—directly from the image instead of using the detected body parts. Here, we show that convolutional neural networks (CNNs)—a machine learning approach that recently became the leading technique for object recognition, human pose estimation and human action recognition—were able to recognize directly from images whetherDrosophilawere “on” (standing or walking) or “off” (not in physical contact with) egg-laying substrates for each frame of our videos. We used multiple nets and image transformations to optimize accuracy for our classification task, achieving a surprisingly low error rate of just 0.072%. Classifying one of our 8 h videos took less than 3 h using a fast GPU. The approach enabled uncovering a novel egg-laying-induced behavior modification inDrosophila. Furthermore, it should be readily applicable to other behavior analysis tasks.
Interpretation of Negative Molecular Test Results in Patients With Suspected or Confirmed Ebola Virus Disease: Report of Two Cases
Authors: Edwards Jeffrey K. , Kleine Christian , Munster Vincent , Giuliani Ruggero , Massaquoi Moses , Sprecher Armand , Chertow Daniel S. 
Published: September 2015

Abstract
Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) is the most sensitive quantitative diagnostic assay for detection of Ebola virus in multiple body fluids. Despite the strengths of this assay, we present 2 cases of Ebola virus disease (EVD) and highlight the potential for false-negative results during the early and late stages of EVD. The first case emphasizes the low negative-predictive value of qRT-PCR during incubation and the early febrile stage of EVD, and the second case emphasizes the potential for false-negative results during recovery and late neurologic complications of EVD. Careful interpretation of test results are needed to guide difficult admission and discharge decisions in suspected or confirmed EVD.