bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choses vues, choses vécues : trois histoires d’« archives au château »
Authors: Le Clech Sylvie 
Published: August 2024

À partir de trois expériences personnelles et professionnelles sur une longue durée (1983 – 2020) concernant des fonds d’« archives au château », l’article part des circonstances du contact initial avec les propriétaires, pour arriver à qualifier les lieux de conservation et les modes de traitement de trois fonds d’archives privées en Normandie, Bretagne et Bourgogne-Franche-Comté. Circonstances de la sollicitation du propriétaire, lieux, absence de classement ou classements généralement familiaux apparaissent révélateurs de l'organisation d'une pensée de propriétaire foncier mais aussi d’acteurs de l’histoire qui associent les échelles nationale et locale. La structure des fonds dessine le portrait des « châtelains », personnages appartenant aujourd’hui à une culture minoritaire. La conservation et le traitement de ces trois fonds d’archives se situent alors dans l'objectif de la transmission et de la défense des droits du groupe familial mais aussi dans l’intérêt de la conservation des archives pour incarner une symbolique familiale réactualisée à la période contemporaine. Ainsi, d'un point de vue sociologique, les archives au château, jouent encore un rôle dans ce qui subsiste de la notion révolue de « lignages ». Les objets sont des intermédiaires. Ces trois exemples sont très différents de ceux de propriétés bourgeoises souvent situées dans des régions telles que l’Ile-de-France, où les hybridations familiales apparaissent comme des facteurs de mobilité sociale, mais aussi d’instabilité et d’hétérogénéité des modèles.
La cargaison d’une coque languedocienne arrivant de Chypre en 1358
Authors: Claverie Pierre-Vincent 
Published: August 2024

Le présent article étudie un registre douanier du port d’Aigues-Mortes des années 1357–1358. La fin du manuscrit décrit la cargaison d’une coque chargée d’épices, que 33 négociants occitans rapportèrent de Chypre le 17 novembre 1358. Une présentation liminaire met en exergue la façon de procéder de l’administration française, avant de décrire les produits coloniaux chargés sur la Cigala . Il s’ensuit une analyse du chargement de chaque marchand, avant une comparaison avec les produits importés en Catalogne à la même époque. La cargaison globale du navire atteint les 910 969 besants blancs de Chypre.
La « liberté des plages » : un droit commun d’accès au littoral dans la Livonie médiévale ( xii e – xv e siècle)
Authors: Boestad Tobias 
Published: August 2024

Les privilèges accordés aux marchands allemands au xiii e siècle en Livonie mentionnent un accès libre aux plages de cette région et le droit d’en exploiter certaines ressources (bois, fourrage). Alors que ces clauses ont souvent été interprétées comme des variations sur le thème de la protection des naufragés contre le pillage de leur épave, une copie peu connue d’une charte de l’évêque Nicolas de Riga publiée en 1231 révèle que leurs origines sont plus anciennes. D’autres sources suggèrent que la plage livonienne était alors considérée comme un bien commun : les privilèges commerciaux n’auraient fait qu’étendre aux marchands étrangers les droits dont jouissaient déjà les communautés littorales. Cet article s’efforce donc de comprendre l’évolution de la « plage libre » livonienne de l’époque qui précède la conquête militaire chrétienne de la région à partir de la fin du xii e siècle jusqu’à sa remise en cause par les pouvoirs seigneuriaux dans le courant du xv e siècle, sur fond de concurrence pour les ressources halieutiques.
La femme provençale et sa ceinture. Étude croisée des sources pour les xiv e – xvi e siècles
Authors: Thuaudet Olivier 
Published: August 2024

À compter de la seconde moitié du xiii e siècle, les éléments métalliques appartenant à la ceinture que met au jour l’archéologie et les types de ceinture rencontrés atteignent une variété qui n’avait pas été observée depuis l’époque mérovingienne. L’archéologie, les sources archivistiques et littéraires ainsi que l’iconographie témoignent du fait que la ceinture est à la fois accessoire fonctionnel, accessoire de mode et objet signifiant. Il est possible au moyen de ces sources de caractériser des ceintures typiquement féminines. L’article en propose une typologie et une anthropologie dans le contexte provençal tout en restant ouvert à un contexte plus général.
IFNs: Maestros of the Immune System
Authors: Fox Lindsey E , Lenschow Deborah J 
Published: August 2024

Abstract
This Pillars of Immunology article is a commentary on “Functional role of type I and type II interferons in antiviral defense,” a pivotal article written by U. Müller, U. Steinhoff, L. F. L. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet, and published in Science, in 1994. https://doi.org/10.1126/science.8009221.
Advances in Cardiac Telerehabilitation for Older Adults in the Digital Age: A Narrative Review
Authors: Liu Tiansheng , Zou Jieru , Geng Qingshan , Liu Jingjin 
Published: August 2024

Abstract
The population of older adults is growing worldwide, and cardiovascular disease (CVD) remains their leading cause of death. Cardiac rehabilitation (CR) is an effective secondary prevention measure that has been shown to improve quality of life and exercise function, along with reducing recurrence, rehospitalization, and disability risks among older adults. However, CR participation rates are very low, at <50% of CVD patients, due to transportation issues, travel costs, and long distances to rehabilitation centers, among numerous other reasons. Recently, a novel CR model, cardiac telerehabilitation (CTR), has been suggested to address many of the barriers otherwise encountered in implementing traditional center-based CR (CBCR) programs and subsequently increasing patient participation rates. CTR is a part of telemedicine, involving the provision of personalized telehealth services via wireless devices, such as smartphones, wearables, and video consultations, which can remotely monitor patients and provide objective feedback to those unable or unwilling to participate in traditional CBCR. This article reviews CTR importance, safety, efficacy, cost-effectiveness, and implementation to draw attention to such programs for older adults, enhance secondary prevention, and provide a reference basis for future users.
Unveiling the molecular and comorbidity profile among transfusion-dependent and nontransfusion-dependent beta-thalassemic patients in Baghdad city
Authors: Alaqidi Atyab Abdulhameed , Al-Mamoori Hind Shaker 
Published: August 2024

Abstract:

BACKGROUND:
Beta-thalassemia (BT) is the most common hereditary hemolytic disease in Iraq. The high prevalence rate of this disorder, coupled with, frequently encountered severe clinical course, as well as the life-long burden of comorbidities and complications, have all contributed to its status as one of the most clinically and epidemiologically significant global health issues. This has prompted our efforts to study the molecular map of BT in Baghdad city.

OBJECTIVES:
The aims of this study as to identify the molecular map of BT in patients from Baghdad city with investigating the data from several clinical and disease-associated morbidity parameters to establish potential correlation points.

PATIENTS, MATERIALS AND METHODS:
The molecular profile of HBB gene of 80 transfusion-dependent (TD) and non-TD BT patients from Baghdad thalassemia centers was examined using multiplex polymerase chain reaction and reverse hybridization technique and direct gene sequencing.

RESULTS:
In the current study, 27 different genotypes were characterized. The most predominant displayed genotypes were IVS 1.110 (G>A)/IVS 1.110 (G>A), and IVS 2.1 (G>A)/IVS 2.1 (G>A). Our data also revealed that 70% of the exhibited genotypes were homozygous, and most of those (78.6%) were TD. As for disease comorbidities, cholelithiasis (53.8%), osteoporosis (51.3%), and facial bone deformity (45%) were among the most frequently encountered in our study.

CONCLUSIONS:
The compiling clinical and molecular data revealed in the current study, has indicated an aggregation of certain homozygous BT genotypes in Baghdad city that possibly influenced the comorbidity profiles of our patients.
Seasonal variations in psychiatry outpatient service utilization in a tertiary health care center in subtropical arid regions of northwestern India
Authors: Meena Parth S. , Sharma Anubhuti , Maurya Ayush , Bansal Varun 
Published: August 2024

Background:
Research on climatic parameters contributing to psychiatric disorder seasonality is limited, particularly in subtropical, arid climates like Rajasthan, necessitating investigation into seasonal variations in psychiatric disorder incidence in the region. This study investigates seasonal variations in psychiatric disorder prevalence over 2 years at a Rajasthan tertiary healthcare center, aiming to uncover links with climatic factors.

Aims:
To investigate seasonal variations in the utilization of outpatient psychiatry services and elucidate potential determinants contributing to these temporal variations.

Settings and Design:
This is a hospital-based study. A retrospective chart review of all new patients who utilized psychiatry outpatient services from July 2021 to July 2023 was conducted.

Methods and Material:
Data were gathered from psychiatric outpatient records of adults (July 2021 to July 2023), diagnosed using ICD-10. Seasons were categorized: winter (November–January), spring (February–April), summer (May–July), and rainy (August–October). Meteorological data, temperature, and day length were obtained. Statistical analyses, including Pearson correlation and Chi-square fitness, assessed seasonal associations with psychiatric disorders.

Results:
A total of 29,164 patient records were observed. Depression correlated with temperature and photoperiod. Mania peaked in August, linked to day length. Schizophrenia showed seasonal variation without environmental correlation. Anxiety peaked in March with no statistical significance. Obsessive compulsive disorder cases spiked in June, moderately correlated with temperature and photoperiod. Alcohol-related disorders peaked in December, while opioid dependence remained steady. Cannabis-induced psychosis peaked in summer, strongly correlated with temperature and day length. Headaches surged in August, positively correlated with temperature and day length.

Conclusions:
This study reveals complex relationships between seasonality, environmental factors, and psychiatric disorders, emphasizing their importance in mental health research and practice.
Role of culture and religious beliefs on non-medical help-seeking behavior among patients with chronic mental illnesses (CMIs) in Türkiye
Authors: Ediz Çiçek , Uzun Sevda , Mohammadnezhad Masoud , Erdaş Mehmed B. 
Published: August 2024

Background:
Cultural beliefs significantly shape societal attitudes toward mental illness, and these social attitudes profoundly impact help-seeking behaviors. Therefore, it is important to focus on understanding and addressing these social behaviors.

Aim:
This study aimed to evaluate the effect of chronic mental illness interpretations based on culture and religious beliefs on non-medical help-seeking behaviors among patients in Türkiye.

Methods:
The study was conducted from September to October 2023 using an inductive qualitative approach. In-depth face-to-face interviews were carried out with individuals diagnosed with chronic mental illness and their relatives, registered in a state-owned Community Mental Health Center (CMHC) in Türkiye. Using purposive sampling, 13 individuals who met the criteria were interviewed. Thematic analysis was used to identify themes.

Results:
Three main themes and eight sub-themes were identified, including the reasons for seeking non-medical help (psychological challenges, subjective norms, physical requirements), factors contributing to seeking non-medical help (predisposing factors, enabling factors, and myths), and reflections on the benefits of non-medical practices (perceived physical benefits, perceived psychological benefits).

Conclusions:
It was concluded that individuals with chronic mental illness and their relatives living in the Eastern Anatolia Region of Türkiye engaged in non-medical help-seeking behaviors and mostly turned to traditional religious practices. Culture and religious beliefs emerged as primary factors leading patients to seek non-medical treatment approaches. Consequently, there is a perceived need to explore non-medical alternative methods across various mental health settings and with diverse samples in future research endeavors.
Significance of Wellens Pattern in Electrocardiogram Revisited – Electrocardiogram and Angiographic Correlation
Authors: Chelakkat Mukundan , Karunadas C. P. , Bijilesh U. , Mathew Cibu 
Published: August 2024

Abstract

Background:
In patients with non-ST elevation acute coronary syndrome (NSTEACS), electrocardiogram (ECG) may show deep or biphasic T-wave inversions in precordial leads. Previous reports had linked this ECG change with a lesion in the left anterior descending artery (LAD). However, it is often overlooked in the emergency department and is not included in the major scoring systems for risk stratification of acute coronary syndrome.

Objectives:
We assessed coronary angiogram (CAG) lesions in patients with biphasic T inversion and/or deep T inversions by ECG.

Methods:
From July 2019 to November 2021, ECGs of all NSTEACS patients were analyzed and 202 patients who satisfied the criteria were chosen. CAGs were analyzed for the site, severity, and type of lesion. Treatment modality advice was noted.

Results:
One hundred and ninety-five patients had severe disease in the LAD, of which 178 patients had a lesion proximal to the first septal perforator branch. LAD lesions were discrete in 98, tubular in 68, diffuse in 25, and total occlusion in 11 patients. One hundred and thirty-four patients were advised to have percutaneous coronary intervention (PCI) as treatment. Sixty-three patients with a severe lesion had no recurrent angina and 103 were negative for troponin.

Conclusion:
96.5% of patients with NSTEACS and an ECG abnormality had a significant lesion in the LAD. In 88.1% of patients, the lesion was before the first septal perforator branch. Overall, 66.3% of patients were advised to undergo PCI. The sensitivity of troponin in predicting severe lesion was 47.7%, and the sensitivity of recurrent angina was 67.7% only. This ECG abnormality by itself, even without recurrent angina or troponin elevation, should be an indication for invasive evaluation such as CAG.
Effect of acute and chronic stress on memory impairment and hippocampal oxidative stress following global cerebral ischemia in adult male rats
Authors: Forghani Nafiseh , Hosseinian Sara , Akhoond-Ali Zahra , Gholami Arman Abroumand , Assaran-Darban Reza , Vafaee Farzaneh 
Published: August 2024

Background and purpose:
Stress, especially immobility stress, is quite common and one of the most important and influential risk factors in neurological disorders. This study aimed to investigate the effect of acute and chronic immobility stress on the level of cortical and hippocampal oxidative stress indicators and memory impairment following global cerebral ischemia.

Experimental approach:
In this study, 48 male Wistar rats were randomly divided into 6 groups: 1, sham (S); 2, sham-acute stress (SSA); 3, sham-chronic stress (SSC); 4, ischemia (IS); 5, ischemia-acute stress (ISA); 6, ischemia-chronic stress (ISC). The Morris water maze (MWM) test was performed 14 days after surgery, and cortisol levels and oxidative stress factors such as malondialdehyde MDA and total thiol were measured.

Findings/Results:
In the MWM test, the time to find the platform (latency time) in the ISC and IS groups significantly increased compared to the S group. The time spent in the target quarter in these two groups was significantly reduced compared to the S group on the day of the probe. The results showed a significant increase in cortisol levels and malondialdehyde concentration in the ISA, ISC, and IS groups compared to the S group, but there was no significant difference in total thiol concentration. No significant difference was observed in the level of oxidative stress factors in the cortex.

Conclusion and implication:
Chronic immobility stress could reduce antioxidant factors in the hippocampus and exacerbate memory impairment caused by global ischemia.
Cannabidiol attenuates arsenic-induced nephrotoxicity via the NOX4 and NF-κB pathways in mice
Authors: Vadizadeh Ali , Salehcheh Maryam , Kalantar Hadi , Khorsandi Layasadat , Rashno Mohammad , Mahdavinia Masoud 
Published: August 2024

Background and purpose:
Cannabidiol (CBD) is a phenolic terpene compound with anticancer, antioxidant, anti-inflammatory, antibacterial, neuroprotective, and anticonvulsant properties. Since the effects of CBD on sodium arsenite (As)-induced nephrotoxicity have not been fully determined, this study investigated the effect of CBD on As-induced nephrotoxicity by evaluating the NOX4 and NF-kB pathways in mice.

Experimental approach:
48 male mice were divided into six groups (8 each) including group 1, receiving saline for 14 days; group 2, receiving CBD (10 mg/kg, intraperitoneally) from the 7th to the 14th day; group 3, receiving As (10 mg/kg) for 14 days by gavage; and treatment groups 4-6, receiving CBD (2.5, 5, and 10 mg/kg, i.p.) 1.5 h before As (10 mg/kg by gavage, for 14 days) from the 7th to the 14th day. Mice were anesthetized after overnight fasting on day 15, and the blood sample was collected from their hearts. The level of antioxidants and pro-inflammatory factors, the expression of ROS and TNF-α, NF-kB, NOX4, iNOS, cleaved PARP, and caspase-3 proteins were measured and histological studies were performed.

Findings/Results:
Exposure to As significantly increased kidney markers, oxidative stress, apoptosis, and inflammation in mice kidney tissue, and pretreatment with CBD reversed these changes. In addition, CBD significantly decreased the expression of NF-kB and NOX4, and the levels of pro-inflammatory factors and the expression of cleaved PARP and increased the level of antioxidants.

Conclusion and implications:
CBD ameliorated As-induced nephrotoxicity related to inhibiting oxidative stress, inflammation, and apoptosis, potentially through the NF-kB/Nox4 pathway.
Bilirubin, once a toxin but now an antioxidant alleviating non-alcoholic fatty liver disease in an autophagy-dependent manner in high-fat diet-induced rats: a molecular and histopathological analysis
Authors: Tavakoli Ramin , Maleki Mohammad Hasan , Vakili Omid , Taghizadeh Motahareh , Zal Fatemeh , Shafiee Sayed Mohammad 
Published: August 2024

Background and purpose:
As an endogenous antioxidant, bilirubin has surprisingly been inversely correlated with the risk of non-alcoholic fatty liver disease (NAFLD). Thereupon, the current evaluation was designed to assess the positive effects of bilirubin on the autophagy flux, as well as the other pathogenic processes and parameters involved in the expansion of NAFLD.

Experimental approach:
Thirty adult male rats weighing 150-200 g with free access to sucrose solution (18%) were randomly subdivided into 5 groups (n = 6). Subsequently, the animals were euthanized, and their blood specimens and liver tissue samples were collected to measure serum biochemical indices, liver histopathological changes, intrahepatic triglycerides content, and tissue stereological alterations. Furthermore, the expression levels of autophagy-related genes (Atgs) were measured to assess the state of the autophagy flux.

Findings/Results:
Fasting blood glucose, body weight, as well as liver weight, liver-specific enzyme activity, and serum lipid profile indices markedly decreased in rats that underwent a six-week bilirubin treatment compared to the control group. In addition, histopathological studies showed that hepatic steatosis, fibrosis, inflammation, and necrosis significantly decreased in the groups that received bilirubin compared to the control animals. Bilirubin also caused significant alterations in the expression levels of the Atgs, as well as the Beclin- 1 protein.

Conclusion and implication:
Bilirubin may have potential ameliorative effects on NAFLD-associated liver damage. Moreover, the beneficial effects of bilirubin on intrahepatic lipid accumulation and steatosis were comparable with the group that did not ever receive bilirubin.
Cinnamaldehyde potentiates cytotoxic and apoptogenic effects of doxorubicin in prostate cancer cell line
Authors: Abbassi Abbas , Yaghmaei Parichehr , Hosseinzadeh Leila 
Published: August 2024

Background and purpose:
Nowadays, herbal medicine has been utilized to treat various diseases such as cancer, which showed successful therapeutic efficacy in previous studies. This study for the first time evaluated the cytotoxic potential of cinnamaldehyde (CIN) alone and in combination with doxorubicin (DOX), a well-known potent anti-tumor agent, on the proliferation of prostatic cancer cell line (PC3).

Experimental approach:
The cytotoxicity and apoptotic activities of CIN and DOX, either separately or together, were determined on PC3 cells by the MTT test and Annexin V/PI assay, respectively. To further investigate which apoptotic pathway participated in cell death a collection of prominent markers of apoptosis induction including caspase-3/7 activations, mitochondrial membrane potential (MMP), and phosphatidyl serine translocation were detected.

Findings/Results:
The different concentrations of CIN and DOX significantly inhibited the proliferation of PC3 cells in a concentration-dependent way within a 24-h treatment. In addition, the induction of apoptosis by CIN was accompanied by an increase in the activation of caspase-3/7 in PC3 cells with IC50 concentrations of 12.5 and 10 μg/mL for CIN and DOX, respectively. Moreover, the morphological observations obtained from flow cytometry MMP and caspase-3/7 activity assays, altogether, revealed the potential effect of CIN on apoptosis induced in PC3 cells by DOX.

Conclusions and implications:
Taken together, the current study concluded that the combination of CIN and DOX could lead to the production of a potential therapeutic agent for prostate cancer. However, further in vivo and clinical studies are still needed to validate this combination in prostate cancer therapy.