bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of cold chain management practices on health centers operational performance: A facility Based cross-sectional study
Authors: Girma Million , Mekasha Yesuneh Tefera , Yami Mihret Fikreyesus , Tegegne Addisu Afrassa , Asfaw Abenezer , Beyene Girma , Usure Rashed Edris 
Published: August 2024

Abstract

Background
Access to essential cold chain pharmaceutical products is crucial for improving healthcare. Pharmaceutical organizations recommend a global standard for handling, storing, and distributing these items. However, resource-limited countries like Ethiopia face challenges in implementing cold chain management practices for temperature-sensitive products.
Objective
The study aimed to assess the cold chain management practice, and operational performance in the government health centers in the Administration of Addis Ababa, Ethiopia.
Methods
A cross-sectional facility-based study was conducted on health centers in Addis Ababa from September 5–30, 2023 G.C. Logistic indicator assessment tools were used in 20 health centers. Key informants such as the warehouse manager, pharmacy head, and expanded program immunization focal person were purposefully sampled. Three focal persons were selected from each health center. Generally, sixty (n = 60) study participants were included. Previously published literature and guidelines were used to review cold chain management practice and operational performance. Statistical analyses including the chi-square test, and multivariate regression were conducted, with significance set at p < 0.05.
Results
The study revealed that the majority of 34 individuals (56.7%) possessed work experience exceeding 3 years. As for practice-related aspects, the study showed that storage and facility (4.19 ± 0.271), distribution system (4.01 ± 0.247), technical capacity (4.43 ± 0.116), and information system (4.25 ± 0.138) were deemed sufficient for maintaining cold chain products in health centers. Furthermore, the chi-square test demonstrated a strong correlation (P = 0.0001) between the educational background, work experience, and years of service of employees and their cold chain management practices. The evaluation of cold chain management performance in public health facilities revealed an 85% rate of inaccurate inventory records, 55% undesirable storage practices, 85% inadequate stock records, and a notable level of product wastage (80%) in these health centers. Notably, the experience of respondents in cold chain management, product storage systems and facilities, distribution systems, and technical capacity of health facilities were identified as significant associated factors (p < 0.05 at 95% CI) with the operational performance of cold chain management.
Conclusion
Overall, the findings underscored the importance of addressing operational performance inefficiencies in the handling of cold chain products at health facilities. By implementing better training, standard operating procedures, logistics and inventory management techniques, and infrastructure, health facilities can ensure the quality and efficacy of their cold chain products, ultimately improving patient outcomes and public health.
Antiviral immunity within neural stem cells distinguishes viral strain differences in forebrain organoids
Authors: Vazquez Christine , Negatu Seble , Bannerman Carl , Sri Sowmya , Ming Guo-Li , Jurado Kellie 
Published: August 2024

Abstract

Neural stem cells have intact innate immune responses that protect them from virus infection and cell death. Yet, viruses can antagonize such responses to establish neuropathogenesis. Using a forebrain organoid model system at two developmental time points, we identified that neural stem cells, in particular radial glia, are basally primed to respond to virus infection by upregulating several antiviral interferon-stimulated genes. Infection of these organoids with a neuropathogenic Enterovirus-D68 strain, demonstrated the ability of this virus to impede immune activation by blocking interferon responses. Together, our data highlight immune gene signatures present in different types of neural stem cells and differential viral capacity to block neural-specific immune induction.
Innovative Low Power SRAM Solutions: Memristor-Enhanced 4T2M and 6T2M Architectures with MTCMOS Techniques
Authors: BR Harshitha , S Jalaja 
Published: August 2024

Abstract

In recent years, the demand for low-power devices has surged, driven by the scaling of CMOS technology, resulting in smaller chip sizes and higher transistor densities within System on Chip (SoC) designs, including memory components. This paper introduces the design and evaluation of Memristor-based SRAM, leveraging the unique properties of memristors to enhance power efficiency and processing speed. The integration of memristors reduces the transistor count, transitioning from traditional 6T SRAM to a 4T2M configuration and from 8T to 6T2M power usage. To further reduce power consumption, we implement the Multi-Threshold CMOS (MTCMOS) technique, known for minimizing leakage power by selectively deactivating inactive circuit domains. We perform a detailed analysis and parameterization of Memristor-based SRAM, including an MTCMOS-enhanced configuration, using the Cadence Virtuoso tool at a 90nm process technology with an operating voltage of 1.2 volts. This study addresses the pressing need for low-power memory solutions in modern electronic devices, focusing on the analysis and optimization of Memristor-based SRAM configurations.
MS-CETSA functional proteomics uncovers new DNA-repair programs leading to Gemcitabine resistance
Authors: Nordlund Pär , Liang Ying Yu , Khalid Khalidah , Le Hai Van , Teo Hui Min , Raitelaitis Mindaugas , Gerault Marc-Antoine , Lee Jane Jia Hui , Lyu Jiawen , Chan Allison , Jeyashekharan Anand , Tam Wai Leong , Prabhu Nayana 
Published: August 2024

Abstract

Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementation of CETSA (Cellular Thermal Shift Assay) revealing a range of induced biochemical responses to gemcitabine in resistant and sensitive diffuse large B cell lymphoma (DLBCL) cell lines. Initial responses in both, gemcitabine resistant and sensitive cells, reflect known targeted effects by gemcitabine on ribonucleotide reductase and DNA damage responses. However, after 3-5 hours the responses diverge dramatically where sensitive cells show induction of characteristic CETSA signals for early apoptosis, while resistant cells reveal biochemical modulations reflecting transition through a distinct DNA-damage signaling state, including opening of cell cycle checkpoints and induction of translesion DNA synthesis (TLS) programs allowing bypass of damaged DNA-adducts. The data also reveal the induction of a new program, labeled the Auxiliary DNA Damage Repair (ADDR) protein ensemble likely supporting DNA replication at damaged sites. We show that this response can be attenuated in resistant cells by an ATR inhibitor re-establishing gemcitabine sensitivity and demonstrate ATR as a key signaling node of this response.
Perspective on Patient-centered Communication: A Focus Group Study Investigating the Experiences and Needs of Nursing Professionals
Authors: Mielke Kendra , Frerichs Wiebke , Cöllen Katja , Lindig Anja , Härter Martin , Scholl Isabelle 
Published: August 2024

Abstract

Background
Delivering high quality care tailored to patients’ needs necessitates patient-centered communication. High physical and metal workload, as well as organizational barriers, contribute to challenges nurses face in patient-centered communication. Participation in a communication skills training can help nurses to improve their patient-centered communication skills. Thus, the aim of this study was to investigate the experiences of nursing professionals in patient-centered communication and delineate the requisite content for a communication skills training.
Methods
We conducted focus group interviews with nursing professionals working at an academic medical center in Germany. The focus group interviews were audio-recorded and transcribed verbatim. Data analysis was performed using Kuckartz’s qualitative content analysis.
Results
31 nursing professionals from diverse medical disciplines (e.g. pediatrics, obstetrics, cardiology, neurology, oncology) participated in the study, unveiling a spectrum of communication experiences, including organizational and system-related challenges, constraints induced by the COVID-19 pandemic, management of personal emotions, and communication challenges with patients and relatives. They also identified aspects they experienced as beneficial for patient-centered communication (e.g., allocating sufficient time, being authentic, providing clear information). Furthermore, participants identified specific aspects that should be included in a patient-centered communication skills training.
Conclusion
The findings suggests that not only nurses from oncology and intensive care, but also from other medical disciplines, experience significant communication challenges with patients and relatives. Applying patient-centered aspects of communication was considered beneficial for effective communication. The needs identified through participants' experiences informed the development of patient-centered communication skills training specifically tailored for nursing professionals across diverse medical disinclines in Germany.
STREAM: High Bandwidth, Reliable TCP Bridging in Low-Mobility Wi-Fi Direct Networks
Authors: Dao Mawaba P. , Sheldon Joshua , Nieves-Acaron David , Wyatt Steven , Elliott David , Otero Carlos E. , Peter Adrian M. 
Published: August 2024

Abstract

Ad-hoc networks facilitate localized communication in environments lacking global internet connectivity. However, traditional Wi-Fi Direct (WFD) methods face challenges in forming intergroup networks during field deployments, due to manual password entry, single-path traffic between Group Owners (GOs), and performance bottlenecks from UDP multicast. To address these issues, we propose a Simple TCP-enabled, REsilient Android Mesh (STREAM); a multigroup bridging strategy where WFD Group Members (GMs) join two groups and bridge the connection between them exclusively using TCP sockets --an accomplishment yet to be realized in WFD ad-hoc networks on stock Android devices. This approach maximizes throughput and resilience for intergroup connections. STREAM also features self-healing capabilities to detect and rectify network disruptions automatically, removing the need for user intervention. Our architecture leverages Wi-Fi bandwidth, achieving average file transfer speeds of 91.2 Mbps in intergroup networks, demonstrating a significant performance improvement. Our results show that STREAM offers a solution for developing scalable and reliable multigroup Wi-Fi Direct networks.
Could Wearable Voltage-Triggered Paper Patch Revolutionize Psoriasis Treatment by Enhancing Skin Permeation of Methotrexate?
Authors: Mehrgardi Masoud , Momtaz Elham 
Published: August 2024

Abstract

This study introduces a wearable iontophoresis transdermal paper patch for delivering methotrexate, a potent anti-inflammatory drug, to treat imiquimod (IMQ)-induced psoriasis-like inflammations. This patch features a paper-based electrode that has been coated with polypyrrole and loaded with the anti-inflammatory medication methotrexate. Incorporating paper into the design enhanced the amount of drug that could be loaded and reduced its unintended release. The most effective release of the drug, was achieved with a voltage of -1.2 V. The specially designed iontophoresis patch ensured that the methotrexate optimally penetrated the mouse skin (19.7 ± 0.5 µg cm− 2 after 2 h). The patch's ability to alleviate psoriasis, which was experimentally induced in BALB/c mice (gender random), was confirmed through successful testing. Histological analysis of the skin and internal organs such as the spleen, lungs, liver, and kidneys showed that methotrexate is highly effective and has minimal adverse effects.
Unraveling Overestimated Exposure Risks Through Hourly Ozone Retrievals from Next-Generation Geostationary Satellites
Authors: Li Siwei , Song Ge , Xing Jia , Dong Jiaxin , Zhang Maolin , Fan Chunying , Meng Shiyao , Yang Jie , Dong Lechao 
Published: August 2024

Abstract

Accurately estimating ground-level ozone (O₃) concentration is essential for understanding its health impact and designing effective control strategies. Current estimates rely heavily on polar-orbit satellites, which provide limited, one-time measurements and fail to capture the significant diurnal variability of O₃. In this study, we leverage the next-generation geostationary satellite equipped with ultraviolet capabilities, the Geostationary Environment Monitoring Spectrometer (GEMS), to retrieve O₃ concentration on an hourly basis. Besides accurately capturing hourly-level O₃ concentration (with R² = 0.94), this approach significantly improved the accuracy of daily maximum 8-hour average O3 estimates, particularly in semi-urban regions, enhancing the R² by over 0.10 and reducing absolute error exceeding 7 µg/m³. Moreover, our analysis indicates a 30% reduction in O₃-related health risks, with a total reduction in both short-term and long-term mortality compared to previous estimates based on traditional polar-orbit satellites. This reduction is particularly notable in semi-urban and rural areas, where satellite data plays a more important role due to the lack of ground measurements compared to urban areas. This suggests that previous estimates may have significantly overestimated not only the total mortalities but also the urban-rural spillover effects. Our results underscore the importance of utilizing high temporal resolution geostationary satellites with refined hourly information on photochemical precursors and radiation to accurately capture O₃ diurnal variability, providing a scientific foundation for health assessments and informing standards and regulatory interventions to combat O₃ pollution in China.
Emotion Regulation Goals and Strategies of Individuals with Low Distress Tolerance
Authors: Rafezi Zohreh 
Published: August 2024

Abstract

Studies have shown that goals determine strategies in the emotion regulation processes. However, poor distress tolerance is related to a higher use of maladaptive strategies. This research examines the relationships between distress tolerance, goals, and strategies of emotion regulation. Furthermore, it investigates the daily goals and strategies of individuals with low distress tolerance. In Study 1, students at the University of Tehran (N = 258; Mean age = 22.63) completed self-report measures; in the next study, the students with low distress tolerance (N = 78; Mean age = 21.7) recorded their daily goals and strategies for 14 consecutive days. Linear regression and multilevel modeling were used to analyze the data from Study 1 and 2, respectively. Distress tolerance was negatively associated with impression management and pro-social goals, as well as experiential avoidance, expressive suppression, and rumination strategies. Moreover, distress tolerance predicted a higher use of cognitive reappraisal. In Study 2, impression management goals and experiential avoidance had more frequency and stability (trait). Across both studies, impression management goals were related to a greater use of experiential avoidance, expressive suppression, and rumination. Additionally, pro-hedonic goals were positively related to cognitive reappraisal and negatively related to expressive suppression. However, the findings regarding the relationships between pro-social goals and strategies were mixed. The current studies indicate that the ability to tolerate distress has a significant impact on emotion regulation goals as well as strategies. Moreover, different strategies are predicted by different goals at the habitual and daily levels, and in general and low distress tolerance populations.
Dragonfly: A Portable Molecular Diagnostic Platform for Rapid Point-of-Care Detection of Mpox and Other Diseases
Authors: Manzano Jesus Rodriguez , Cavuto Matthew , Cardenas Kenny Malpartida , Pennisi Ivana , Pond Marcus , Mirza Sohail , Moser Nicholas , Comer Mark , Stokes Isobel , Eke Lucy , Lant Sian , Szostak Katarzyna , Miglietta Luca , Stringer Oliver , Sumner Rebecca , Bolt Frances , Sriskan Shiranee , Holmes Alison , Georgiou Pantelis , Ulaeto David (O) , de Motes Carlos Maluquer 
Published: August 2024

Abstract

The explosive global spread of Clade II mpox in humans and sustained human-to-human transmission of the more virulent Clade I mpox in the Democratic Republic of Congo highlight both the current lack of, and critical need for, point-of-care diagnostics to address the spread of this emergent disease. A novel point-of-care molecular diagnostic platform, Dragonfly, was developed that integrates power-free nucleic acid extraction (< 5 minutes) and lyophilized colorimetric LAMP chemistry. The platform achieved an analytical limit-of-detection of 50 genome copies/reaction for monkeypox virus, distinguishing it from other orthopoxviruses, herpes simplex virus and varizella zoster virus. Clinical validation using 164 samples, including 51 mpox positives, demonstrated 96.1% sensitivity and 100% specificity for orthopoxviruses, and 94.1% sensitivity and 100% specificity for monkeypox virus. Our platform provides a rapid, accessible and robust point-of-care solution for monitoring mpox in both low and high resource settings amidst declining worldwide smallpox immunity, with broad potential to the wider field of infectious disease diagnosis as a whole.
Effect of Inflation Rate on the Agricultural and Manufacturing Sector in Nigeria (1990-2021)
Authors: Adeoye Peter Ayodeji 
Published: August 2024

Abstract

This work examines the effect of inflation rate on the performance of manufacturing and agricultural sectors. Yearly data were used from 1975 to 2020. The Auto Regressive Distributed Lag (ARDL) was used to analyse the data, and the yearly data were sourced from Word Development indicator (WDI) and Central Bank of Nigerian (CBN) Statistical Bulletin. This research work considers inflation rate, credit to private sector (PRIVATECREDIT), manufacturing capacity utilization (MCAPUTIL), foreign direct investment (FDI), credit to agriculture (AGRICCREDIT), agriculture equipment (AGRICEQUIP)and Exchange rate (EXCH) as independent variables on agricultural output and MVA. Based on ARDL approach, based on ARDL approach, test was carried out on each dependent variable and the independent variable to check the long and short run regression findings for the coefficient of the lagged values of the dependent and independent variables. Some diagnostic test like the serial correlation test, heteroskedasticity test, and stability test were also carried out on the variables. From the results obtained, agricultural equipment, and exchange rate are statistically significance to agricultural output. Foreign direct investment, and inflation rate has statistical significance on manufacturing output. It is therefore recommended that Government should always check on the increase of inflation rate and how it is affecting the performance of the manufacturing sector and agricultural sectors so as to provide necessary solution in case if any problem arises. There should be an encouragement of foreign investment into the manufacturing sector in the country.
Spatial Analysis of Sustainable and Agricultural Development in Southern Brazil
Authors: Lisbinski Fernanda Cigainski , Freitas Felipe André Oliveira 
Published: August 2024

Abstract

This work sought to create and analyze a Sustainable and Agricultural Development Index (SADI) for the municipalities that make up the Southern Region of the country. For this, the methodology used was the factor analysis through the analysis of principal components and, subsequently, the exploratory analysis of spatial data (ESDA) was performed, verifying the distribution of the indicator. The main results revealed that the values found for the indicators showed a medium-low degree, considering that the highest value found was 0.5885 and the others presented values below 0.5. The municipalities with the highest indicators, with the highest degree of sustainable and agricultural development, were Curitiba (PR) (0.5885); Capivari do Sul (RS) (0.4541); and Paranapoema (PR) (0.4536). While the lowest indicators, with a lower degree of sustainable and agricultural development, were: Bombinhas (SC), (0.1843); Governador Celso Ramos (SC) (0.2170); and Matinhos (PR) (0.2172). Regarding the ESDA, it showed strong evidence of a positive and significant spatial correlation between the municipalities analyzed, in addition, there was a high disparity in the sustainable and agricultural development of the municipalities that make up these states.
Innovations in economic assessment of drought: an application to the US southwest
Authors: Shadabi Leila , Ward Frank A. 
Published: August 2024

ABSTRACT

While numerous studies have examined the economic repercussions of drought, there remains a gap in integrated analyses comprehensively assessing its economic effects, especially where there is no drought adaptation policy under debate calling for a standard cost-benefit analysis. This work's first contribution comes from the development of a non-linear econometric model predicting total county income for several counties and years, for which population growth in some regions showed increasing water use despite the presence of drought. Using the arid southwest US state of New Mexico as a case study for the drought years of 2017–2019, this work develops a second innovation to assess drought damages based on comparing changes in per capita water use from 2015 to those later years. Using those two innovations, total economic damages to water users summed over the three drought years amount to $1.983 billion, just under 1% of the state's total income for that period. Overall, the effects of drought in New Mexico were more modest than anticipated partly because water users in this state showed remarkable resilience in handling water shortages due to several unique structural features of the state's income generation processes.
Factors influencing households' satisfaction with drinking water availability in Bujumbura Municipality, Burundi
Authors: Barankanira Emmanuel , Nkurunziza Innocent , Bisore Simon , Niyongabo Désiré 
Published: August 2024

ABSTRACT
Consumer satisfaction and drinking water availability in evolving urban settings are major issues and their understanding is a key to improving water service quality and managing water utility. This study aims to examine factors influencing subscribers' satisfaction with drinking water availability in the Municipality of Bujumbura, Burundi. To achieve this, a survey was carried out from 3 to 21 May 2021 on a random sample of 391 subscribers. The outcome variable was the logarithm of the odds of being satisfied with drinking water availability and explanatory variables included sociodemographic factors (commune, gender, age, education level, marital status, and religion), water distribution factors and co-production-related factors. The chi-square test (Fisher's exact test if conditions are not met) and binary fixed-effects logistic regression models were applied to these data using R software, version 4.1.2. Findings showed that the time of drinking water supply and frequency of water-related outages significantly influenced satisfaction with drinking water availability after adjustment for age. This study could help decision-makers who are in charge of drinking water distribution identify other factors associated with water availability satisfaction in Bujumbura Municipality and other urban settings.