bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consistent condom use among Botswana’s female population and associated factors
Authors: Mlandu Chenai , Machisa Mercilene , Christofides Nicola 
Published: August 2024

Background: Botswana is one of the countries severely impacted by the HIV/AIDS pandemic. Despite an extensive HIV prevention campaign, the incidence of HIV, particularly among women, remains high. Condoms play a significant role in preventing new HIV infections, although men and women do not consistently use them. Objective: The study assessed the individual, relationship and community factors associated with consistent condom use among women in Botswana. Design: A cross-sectional study using secondary data drawn from a national survey on Gender-Based Violence Indicators in 2012. Methods: The primary survey sampled 639 women, aged 18 years and older, using a multistage procedure. The final sample size for the secondary analysis included a total of 480 women who were sexually experienced and had reported using condoms with their male partners. Multivariate logistic regression analysis was employed to assess the association between consistent condom use and the explanatory variables. The multivariate logistic regression adjusted for cluster/community random effects. Results: About 43% of the women used condoms consistently in the past year. Consistent condom use was more likely among women who were employed in the past year (adjusted odds ratio = 1.77; 95% confidence interval = 1.25-2.50). While, women who lived with their partners (adjusted odds ratio = 0.46; 95% confidence interval = 0.28–0.74), had non-Christian beliefs (adjusted odds ratio = 0.52; 95% confidence interval = 0.29–0.92), perceived that their partners would be angry if they ask to use a condom (adjusted odds ratio = 0.19; 95% confidence interval = 0.06–0.58) and perceived that their community says women need their husband’s permission to do paid work (adjusted odds ratio = 0.56; 95% confidence interval = 0.38–0.83) were less likely to use condoms consistently. Conclusion: Consistent condom use among Botswana’s female population is suboptimal. Consistent condom use was higher among women with employment, and lower among women who lived with their partners, had non-Christian beliefs, feared their partners’ reaction upon asking for condom use and held inequitable community gender beliefs. To enhance women’s consistent use of condoms, friendly condom use information, female economic empowerment strategies and programmes that involve religious leaders and promote progressive and healthy masculine practices in Sexual Reproductive Health/HIV interventions should be considered.
Examination of the COVID-19 fear levels of nurses and their compliance to isolation
Authors: Acar Rabia , Sarikaya Aklime , Yildirim Dilek 
Published: August 2024

Background It is very important for healthcare professionals to know the isolation precautions and apply the isolation rules correctly in COVID-19 process. Aim This study was conducted to determine the COVID-19 fear levels and isolation compliance levels of nurses. Method This descriptive, cross-sectional, and correlational study was conducted between December 2020-February 2021 with 217 nurses working in a public hospital in Istanbul/Turkey. Data were collected using the Sociodemographic-Form, the COVID-19 Fear Scale, and the Compliance with Isolation Measures Scale. Results Statistically significant difference was found between the level of compliance with the isolation measures and the education level of the nurses ( p = .011), as well as their professional position ( p = .026) ( p < .05). A positive, low-level significant relationship was determined between the COVID-19 fear of nurses and their compliance with isolation measures (r = 0.168; p = .015). Conclusions It was determined that nurses’ compliance with Isolation Precautions and their level of fear were high during the COVID-19 pandemic. It was observed that nurses’ fear levels and isolation adaptation levels were related.
Malvidin From Malva sylvestris L. Ameliorates Allergic Responses in Ovalbumin-Induced Allergic Rhinitis Mouse Model via the STAT6/GATA3 Pathway
Authors: Yirui Luo , Tao Li , Ruowu Liu , Jiao Zhou , Jing Zhou , Xiaodong Xu , Yan Yan , Bachert Claus , Jintao Du , Luo Ba 
Published: August 2024

Background Malva sylvestris L. (commonly known as mallow) has been widely used in traditional Tibetan formulations to treat allergic rhinitis (AR), and malvidin is a key anti-inflammation constituent of this plant. Objective The present study aimed to evaluate the potential therapeutic effect and mechanism of malvidin in an AR mouse model. Methods Malvidin's efficacy was evaluated in an AR mouse model induced by ovalbumin (OVA) sensitization and challenge. The factors, such as nasal symptoms, serum OVA-specific immunoglobulin E (IgE) levels, histological changes in the nasal mucosa, and expressions of Th1, Th2, Th17, and Tregs and their cytokines, were assessed. Western blotting was used to analyze the effect of malvidin on signal transducer and activator of transcription 6 (STAT6) and GATA3 expression levels. Results Malvidin reduced the allergic symptoms and serum levels of OVA-specific IgE in the AR model. Histological analysis indicated that malvidin alleviates nasal mucosal edema, eosinophil infiltration, and goblet cell proliferation. In addition, it altered the expression of Th1/Th2/Th17-related cytokines, enhanced the Treg population, and reduced Th2-mediated immunity by suppressing the phosphorylation of STAT6 and expression of the GATA3 protein. Conclusions Malvidin significantly improved allergic symptoms in an OVA-induced AR mouse model by modulating Th1/Th2 immune responses and suppressing the STAT6/GATA3 pathway, indicating its potential as a naturally sourced agent for AR management.
Experimental and numerical investigation of heat evolution inside the autoclave for composite manufacturing
Authors: Rangapuram M , Dasari SK , Abutunis A , Chandrashekhara K , Lua J , Li R 
Published: August 2024

Temperature uniformity inside the autoclave and in the manufactured thermoset composite part is the key to enhancing curing performance. The present study incorporated experimental setup, multiphysics and computational fluid dynamics (CFD) models to provide insight into the gas flow pattern and temperature distribution inside the autoclave besides temperature and curing evolution in composite parts during the manufacturing process. The ultimate goal is to help improve the uniformity of the degree of curing and produce robust composite parts. The used numerical models were validated by experiment and the predicted results were in agreement with experimental efforts with a difference of 5%. A maximum temperature difference of 3 K was observed for panel 1, 1 K for panel 2, and 4 K for panel 3 during the curing stages. The variation was more pronounced during the post-curing stage, especially at the center. Correspondingly, less degree of curing (DOC) occurred at the center. The DOC variation between the center and the sides at the base of the panel is 2.5%. Variation in DOC across the thickness of the composite panels was also observed due to thermal spikes and uneven heat transfer. The DOC variation between upper surface and midplane is about 11%. Regions of high turbulence intensity lead to better heat transfer while regions of low speed such as confined regions under the tooling table had the poorest heat transfer. The study provided some practical implications to reduce the non-uniformity in temperature distribution and improve part curing.
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD)
Authors: Xie Bin , Chen Qiong , Dai Ziyu , Jiang Chen , Chen Xi 
Published: August 2024

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease associated with high morbidity and mortality worldwide. Oxidative injury and mitochondrial dysfunction in the airway epithelium are major events in COPD progression.

Methods and results
The therapeutic effects of Progesterone (P4) were investigated in vivo and in vitro in this study. In vivo, in a cigarette smoke (CS) exposure-induced COPD mouse model, P4 treatment significantly ameliorated CS exposure-induced physiological and pathological characteristics, including inflammatory cell infiltration and oxidative injury, in a dose-dependent manner. The c-MYC/SIRT1/PGC-1α pathway is involved in the protective function of P4 against CS-induced COPD. In vitro, P4 co-treatment significantly ameliorated H2O2-induced oxidative injury and mitochondrial dysfunctions by promoting cell proliferation, increasing mitochondrial membrane potential, decreasing ROS levels and apoptosis, and increasing ATP content. Moreover, P4 co-treatment partially attenuated H2O2-caused inhibition in Nrf1, Tfam, Mfn1, PGR-B, c-MYC, SIRT1, and PGC-1α levels. In BEAS-2B and ASM cells, the c-MYC/SIRT1 axis regulated P4’s protective effects against H2O2-induced oxidative injury and mitochondrial dysfunctions.

Conclusion
P4 activates the c-MYC/SIRT1 axis, ameliorating CS-induced COPD and protecting both airway epithelial cells and smooth muscle cells against H2O2-induced oxidative damage. PGC-1α and downstream mitochondrial signaling pathways might be involved.
Greener healing: sustainable nanotechnology for advanced wound care
Authors: Sharda Deepinder , Attri Komal , Choudhury Diptiman 
Published: August 2024

AbstractWound healing involves a carefully regulated sequence of events, encompassing pro-inflammatory and anti-inflammatory stages, tissue regeneration, and remodeling. However, in individuals with diabetes, this process gets disrupted due to dysregulation caused by elevated glucose levels and pro-inflammatory cytokines in the bloodstream. Consequently, the pro-inflammatory stage is prolonged, while the anti-inflammatory phase is delayed, leading to impaired tissue regeneration and remodeling with extended healing time. Furthermore, the increased glucose levels in open wounds create an environment conducive to microbial growth and tissue sepsis, which can escalate to the point of limb amputation. Managing diabetic wounds requires meticulous care and monitoring due to the lack of widely available preventative and therapeutic measures. Existing clinical interventions have limitations, such as slow recovery rates, high costs, and inefficient drug delivery methods. Therefore, exploring alternative avenues to develop effective wound-healing treatments is essential. Nature offers a vast array of resources in the form of secondary metabolites, notably polyphenols, known for their antimicrobial, anti-inflammatory, antioxidant, glucose-regulating, and cell growth-promoting properties. Additionally, nanoparticles synthesized through environmentally friendly methods hold promise for wound healing applications in diabetic and non-diabetic conditions. This review provides a comprehensive discussion and summary of the potential wound-healing abilities of specific natural polyphenols and their nanoparticles. It explores the mechanisms of action underlying their efficacy and presents effective formulations for promoting wound-healing activity.
Graphical abstract
Mussels with luggage: the influence of artificially attached “backpack” devices on mussel movement behavior
Authors: Drainas Konstantina , Beggel Sebastian , Geist Juergen 
Published: August 2024

Abstract
Background
Freshwater mussels are important keystone and indicator species of aquatic ecosystems. Recent advances in sensor technology facilitate applications to individually track mussels and to record and monitor their behavior and physiology. These approaches require the attachment of sensor devices as “backpacks” to the outer shell surface. The interpretation of such data makes it necessary to understand the influence of these attachments on the horizontal and vertical movement behaviors of freshwater mussels. Over a series of mesocosm experiments, this study systematically investigated the effects of three size- and wiring-specific variants of artificially attached backpacks on the horizontal and vertical movement behavior of Anodonta anatina.

Results
Across all experiments, equipping mussels with backpacks did not result in a significant influence on horizontal movement for any of the backpack variants. In contrast to this finding, the big backpacks with a high ratio between backpack volume and mussel length resulted in a significantly negative effect on vertical movement, indicating a potential for adverse effects of such devices on mussels, especially in natural settings.

Conclusions
The findings of this study show that assessing the effects of attached devices on mussels requires a species-specific evaluation of potential impacts on the endpoints of interest. Especially for vertical movement patterns, selection of the smallest available devices appears mandatory.
Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation: a randomized controlled trial
Authors: Fathy Wael , Hussein Mona , Elanwar Rehab , Elmoutaz Hatem , Abdelsadek Donya A , Kassim Dina Y 
Published: August 2024

Abstract
Background
Over the last two decades, a large body of literature has focused on studying the prevalence and outcome of the postoperative delirium and sleep disturbance. The aim of this work was to evaluate the effect of intraoperative administration of Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation.

Methods
This prospective randomized controlled trial was carried out on 80 patients indicated for lumbar fixation; 40 of them received conventional general anesthesia with extra administration of intraoperative magnesium sulphate (Mg sulphate group), and the other 40 received conventional general anesthesia only (control group). Both groups were submitted to pre-operative assessment of depression using Beck Depression inventory (BDI) scale, pre-operative assessment of fatigue using a fatigue questionnaire, pre- and post-operative assessment of insomnia using Insomnia severity index (ISI), post-operative assessment of delirium using Memorial delirium assessment scale (MDAS), post-operative assessment of pain using Visual Analogue Scale (VAS), and pre- and post-operative Quantitative electroencephalography (QEEG).

Results
Mg sulphate administration, age, pre-operative BDI, pre-operative ISI, and post-operative VAS were independent predictors of post-operative ISI (P-value < 0.001, 0.047, 0.021, < 0.001, and < 0.001 respectively). Age and post-operative VAS were independent predictors of post-operative MDAS (P-value = 0.008, 0.013 respectively). Mg sulphate administration and pre-operative ISI were independent predictors of post-operative VAS (P-value = 0.010, 0.006 respectively).

Conclusion
There was a significant relationship between intraoperative Mg sulphate administration and both post-operative insomnia and pain in unadjusted and adjusted analysis.
Panel miRNAs are potential diagnostic markers for chronic kidney diseases: a systematic review and meta-analysis
Authors: Garmaa Gantsetseg , Nagy Rita , Kói Tamás , To Uyen Nguyen Do , Gergő Dorottya , Kleiner Dénes , Csupor Dezső , Hegyi Péter , Kökény Gábor 
Published: August 2024

Abstract
Background
Accurate detection of kidney damage is key to preventing renal failure, and identifying biomarkers is essential for this purpose. We aimed to assess the accuracy of miRNAs as diagnostic tools for chronic kidney disease (CKD).

Methods
We thoroughly searched five databases (MEDLINE, Web of Science, Embase, Scopus, and CENTRAL) and performed a meta-analysis using R software. We assessed the overall diagnostic potential using the pooled area under the curve (pAUC), sensitivity (SEN), and specificity (SPE) values and the risk of bias by using the QUADAS-2 tool. The study protocol was registered on PROSPERO (CRD42021282785).

Results
We analyzed data from 8351 CKD patients, 2989 healthy individuals, and 4331 people with chronic diseases. Among the single miRNAs, the pooled SEN was 0.82, and the SPE was 0.81 for diabetic nephropathy (DN) vs. diabetes mellitus (DM). The SEN and SPE were 0.91 and 0.89 for DN and healthy controls, respectively. miR-192 was the most frequently reported miRNA in DN patients, with a pAUC of 0.91 and SEN and SPE of 0.89 and 0.89, respectively, compared to those in healthy controls. The panel of miRNAs outperformed the single miRNAs (pAUC of 0.86 vs. 0.79, p < 0.05). The SEN and SPE of the panel miRNAs were 0.89 and 0.73, respectively, for DN vs. DM. In the lupus nephritis (LN) vs. systemic lupus erythematosus (SLE) cohorts, the SEN and SPE were 0.84 and 0.81, respectively. Urinary miRNAs tended to be more effective than blood miRNAs (p = 0.06).

Conclusion
MiRNAs show promise as effective diagnostic markers for CKD. The detection of miRNAs in urine and the use of a panel of miRNAs allows more accurate diagnosis.
Understanding the socio-demographic and programmatic factors associated with adolescent motherhood and its association with child undernutrition in Bangladesh
Authors: Hossain Md. Alamgir , Das Novel Chandra , Tariqujjaman Md. , Siddique Abu Bakkar , Chandrima Rubaiya Matin , Uddin Md. Fakhar , Islam S. M Hasibul , Sayeed Abu , Ahmed Anisuddin , Arifeen Shams El , Mahmood Hassan Rushekh , Rahman Ahmed Ehsanur , Hossain Aniqa Tasnim 
Published: August 2024

Abstract
Background
Worldwide, a significant number of girls become mothers during adolescence. In Bangladesh, adolescent childbirth is highly prevalent and has adverse effects on children’s health and undernutrition. We aimed to identify the relationship between the undernutrition of children and adolescent motherhood, the factors associated with adolescent mothers’ age at first birth, and to examine the programmatic factors and gaps influencing children’s undernutrition in Bangladesh.

Methods
We analysed the ‘Bangladesh Demographic and Health Survey’ BDHS-17-18 data and desk review. To examine the factors associated with adolescent motherhood and its impact on child undernutrition, data from 7,643 mother-child pairs were selected. Child stunting, wasting, and underweight were measured according to the World Health Organisation (WHO) median growth guidelines based on z-scores − 2. Univariate, bivariate, simple, and multiple logistic regressions were used for analyse. We followed the systematic procedures for the literature review.

Results
Approximately, 89% of adolescents aged ≤ 19 years were married and 71% of them gave their first childbirth. Children of adolescent mothers (≤ 19 years) were significantly 1.68 times more wasted (aOR: 1.68; 95% CI: 1.08 to 2.64), 1.37 times more underweight (aOR: 1.37; 95% CI: 1.01 to 1.86) and either form 1.32 times more stunting, wasting or underweight (aOR:1.32; 95% Cl: 1.05 to 1.66) compared to the children of adult mothers (> 19 years) after adjusting potential confounders. The factors associated with mothers’ first childbirth during adolescence were the age gap between husband and wife 5–10 years (aOR: 1.81; 95% Cl: 1.57–2.10) and age gap > 10 years (aOR: 2.41; 95% Cl: 1.96–2.97) compared with the age group < 5 years, and husbands’ education (aOR: 1.29; 95% Cl: 1.04–1.61) compared with the uneducated husbands. In the literature review, we found potential gaps in focusing on the Adolescent Sexual and Reproductive Health (ASRH) program in Bangladesh, from thirty-two programmes only half of them focused on adolescents aged 10–19 years, and eleven programmes focused only on girls.

Conclusion
Children of adolescent mothers are at risk of wasting, underweight, and any form of undernutrition. For effective policies and interventions in Bangladesh, it is important to emphasise delaying adolescent pregnancy and prioritising child undernutrition.
Socioeconomic disparities in alcohol-related depression: a national cohort study of low-income medical aid beneficiaries and national health insurance beneficiaries in Korea
Authors: Lee Su Kyoung , Kwon Yong Jin 
Published: August 2024

Abstract
Objective
To examine the association between patterns of alcohol consumption in the past and the risk of depression among medical aid beneficiaries and National Health Insurance beneficiaries in Korea.

Methods
We used data from the National Health Information Database (NHID) of 1,292,618 participants who underwent health checkups in 2015–16 and 2017–18. We categorized alcohol consumption into four groups: continuous high, increased, decreased, and non-consumers. We followed the participants from 2019 to 2021 and identified new episodes of depression. We calculated adjusted odds ratios (aOR) and 95% confidence intervals (CI) for depression by alcohol consumption groups and socioeconomic status.

Results
Medical aid beneficiaries had higher risks of depression than National Health Insurance beneficiaries across all alcohol consumption groups. The highest risk was observed among continuous high consumers (aOR, 2.31; 95% CI, 1.36–3.93), followed by increased (aOR, 1.51; 95% CI, 1.17–1.94), decreased (aOR, 1.48; 95% CI, 1.18–1.84), and non-consumers (aOR, 1.37; 95% CI, 1.22–1.54).

Conclusions
Socioeconomic status and patterns of alcohol consumption in the past are associated with the risk of depression. Public health interventions should consider both factors to reduce alcohol-related depression and health inequalities.
Association between social capital, mental health, and digital health literacy among the university students in China: a multigroup analysis based on major difference
Authors: Zhao Jiajia , Nie Limei , Pan Lutong , Pang Mingli , Wang Jieru , Zhou Yue , Chen Rui , Liu Hui , Xu Xixing , Zhou Chengchao , Li Shixue , Kong Fanlei 
Published: August 2024

Abstract
Background
This study aimed to clarify medical-nonmedical difference on the relationship between social capital, mental health and digital health literacy of university students in China, and furtherly provide evidence-based suggestions on the improvement of the digital health literacy for the university students.

Methods
The snowball sampling method was used to collect data from the university students (including medical students and nonmedical students) through online questionnaires, and finally 1472 university students were included for the data analysis, of whom, 665 (45.18%) were medical students, 807 (54.82%) were nonmedical students; 462 (31.39%) were male, 1010 (68.61%) were female. Mean value of the age was 21.34 ± 2.33 for medical students vs. 20.96 ± 2.16 for nonmedical students. Descriptive analysis, chi-square test analysis, one-way Analysis of Variance (conducted by SPSS) and structural equation modeling (conducted by AMOS) were employed to explore the difference on the relationship between social capital, mental health and digital health literacy between the medical students and nonmedical students.

Results
The mean value of the digital health literacy was 36.27 (37.33 for medical students vs. 35.39 for nonmedical students). The SEM analysis showed that there was a statistically positive correlation between social capital and digital health literacy (stronger among the nonmedical students (0.317) than medical students (0.184)). Mental health had a statistically positive impact on the digital health literacy among medical students (0.242), but statistically significant correlation was not observed in nonmedical students (0.017). Social capital was negatively correlated with the mental health for both medical students and NMS (stronger among the nonmedical students (0.366) than medical students (0.255)). And the fitness indices of SEM were same between medical students and nonmedical students (GFI = 0.911, AGFI = 0.859, CFI = 0.922, RMSEA = 0.074).

Conclusion
The digital health literacy of the university student was relatively high. Both social capital and mental health could exert a positive effect on digital health literacy, while social capital was found to be positively associated with mental health. Statistical difference was found between medical students and nonmedical students on the above correlations. Implications were given on the improvement of the digital health literacy among university students in China.