bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of the Different Outcomes Produced by Genetic Knock Out of the Long Non-coding microRNA-host-gene MIR22HG versus Pharmacologic Antagonism of its Intragenic microRNA product miR-22-3p
Authors: Thibonnier Marc , Ghosh Sujoy 
Published: July 2024

Background:
Publications reveal different outcomes achieved by genetically knocking
out a long non-coding microRNA-host-gene (lncMIRHG) versus the administration of pharmacologic
antagomirs specifically targeting the guide strand of such intragenic microRNA. This
suggests that lncMIRHGs may perform diverse functions unrelated to their role as intragenic
miRNA precursors.

Objective:
This review synthesizes in silico, in vitro, and in vivo findings from our lab and others
to compare the effects of knocking out the long non-coding RNA MIR22HG, which hosts miR-
22, versus administering pharmacological antagomirs targeting miR-22-3p.

Methods:
In silico analyses at the gene, pathway, and network levels reveal both distinct and
overlapping targets of hsa-miR-22-3p and its host gene, MIR22HG. While pharmacological antagomirs
targeting miR-22-3p consistently improve various metabolic parameters in cell culture
and animal models across multiple studies, genetic knockout of MIR22HG yields inconsistent
results among different research groups.

Results:
Additionally, MIR22HG functions as a circulating endogenous RNA (ceRNA) or
"sponge" that simultaneously modulates multiple miRNA-mRNA interactions by competing for
binding to several miRNAs.

Conclusions:
From a therapeutic viewpoint, genetic inactivation of a lncMIRHG and pharmacologic
antagonism of the guide strand of its related intragenic miRNA produce different results.
This should be expected as lncMIRHGs play dual roles, both as lncRNA and as a source for
primary miRNA transcripts.
Characterization of Copper nanoparticles obtained in AOT reverse micelles using flavonoids as a reducing agent
Authors: Rashidi Javid , Ageeva L. S. , Fatyanova E. A. , Borsch N. A. 
Published: July 2024

Purpose of the study. To characterize copper nanoparticles obtained in reverse micelles of sodium bis-(2-ethylhexyl)-sulfosuccinate (AOT) using flavonoids: quercetin and rutin in comparison with traditional reducing agents - sodium borohydride and hydrazine. Methods. Chemical synthesis of copper nanoparticles, spectrophotometry to determine the maximum of the plasmon absorption band of copper nanoparticles, electron transmission microscopy. Results. The reduction of copper ions using flavonoids – quercetin and rutin – confirmed the possibility of obtaining copper nanoparticles in the Cu+2/AOT/isooctane system (AOT is sodium bis-(2-ethylhexyl)-sulfosuccinate, an anionic surfactant that forms the micelle shell). During the formation of nanoparticles, “plasmonic” absorption bands were observed in the electronic spectra in the region of 400-440 nm. In the case of the traditional reducing agent, sodium borohydride, absorption is observed in the region of (439 ± 3) nm, which can also be attributed to the “plasmonic band” of copper nanoparticles, but its intensity is very low, which indicates the formation of a small amount of copper nanoparticles. Using transmission electron microscopy. The average size of copper nanoparticles was determined: 7.1, 8.2 and 18.5 nm in the case of quercetin, rutin and hydrazine, respectively. From the histograms constructed from the results of electron transmission microscopy, it follows that the use of flavonoids as reducing agents makes it possible to reduce the average size of copper nanoparticles and narrow their size distribution. Conclusion. Copper nanoparticles obtained in a reverse micellar solution of AOT in iso-octane using the flavonoids quercetin and rutin as a reducing agent have an average size of 7-8 nm and a narrower size distribution compared to reduction with hydrazine.
Structure and properties of alloys based on electroerosive brass powder LS58-3 obtained in distilled water
Authors: Ageeva E. V. , Abolmasova L. S. , Pereverzev A. S. 
Published: July 2024

The purpose of this work was to study the microstructure and physico-mechanical properties of alloy blanks based on electroerosive powder brass of the LS58-3 brand obtained in distilled water. Methods. To carry out the planned research, waste of the LS58-3 alloy was selected. Distilled water was used as the working fluid. In an experimental patented installation for producing powders, waste LS58-3 alloy was dispersed in distilled water with a load mass of 300 g. The following modes were used: capacitor capacity 45–65 μF; voltage at the electrodes from 150–200 V; pulse repetition rate 50–100 Hz. The preparation of new alloy blanks was carried out using an SPS 25-10 electric spark plasma sintering installation (ThermalTechnology, USA). The microstructure of new alloy workpieces was studied using an electron-ion scanning (raster) microscope QUANTA 600 FEG (Netherlands). The study of the porosity of workpieces of new alloys was carried out using an optical inverted microscope OLYMPUS GX51 (Japan). The study of microhardness of workpieces of new alloys was carried out using an automated microhardness tester AFFRI DM-8 (Vickers). Results. Analysis of the microstructure showed that the sample has a fine-grained structure and a homogeneous surface. According to the obtained porosity analysis results, the sample has less than 1% pores, which is achieved thanks to the technology of spark plasma sintering of the powder. Analysis of the microhardness of the sample showed a significant increase in microhardness, which is explained by the presence of high-hard particles formed during quenching of metal vapor in the working fluid during dispersion. Conclusion. The use of spark plasma sintering technology for electroerosive brass makes it possible to obtain blanks of new alloys with a practically non-porous structure, which leads to an increase in the hardness of the resulting blanks. The results of the conducted studies make it possible to recommend the use of the resulting powder as a starting material for the production of alloy blanks and to expand the scope of their practical application.
Magnetron carbon structures obtained by high-frequency magnetron sputtering in Argon and Nitrogen
Authors: Kuzmenko A. P. , Kolpakov A. I. , Sizov A. S. , Emelyanov V. M. , Neruchev Yu. A. 
Published: July 2024

Purpose of research. Creation and characterization of carbon nanostructures by high-frequency magnetron sputtering from a carbon target in argon on a silicon substrate and in a reactive nitrogen environment, obtained on a Ni catalyst buffer layer. Methods. High-frequency magnetron sputtering on a silicon substrate with changes in control parameters: sputtering time power and working gas pressure Ar and N. Research was carried out using X-ray phase analysis, atomic force microscopy and holographic microscopy, Raman scattering. Results. The formation of carbon nanotubes, including single-walled ones, was confirmed by the method of Raman scattering of light along the lines ID 1363 and IG 1564 cm-1, as well as ωRDМ 308 and 227 cm–1. Using atomic force microscopic images, the fractal dimension of the nanofilms was calculated, which indicated their 3D nature. Based on X-ray phase analysis of magnetron nanofilms, the dimensions of the coherence region, texture, microdeformations and interplanar deformation distortions were determined. Conclusion. In carbon magnetron nanofilms, deformations of both signs occur: both compressive (∆a < 0) and tensile (∆a > 0). Carbon magnetron nanofilms are represented, among other things, by single-walled carbon nanotubes, the chirality of which in an argon environment is (6, 6), and in a reactive mixture of nitrogen and argon on a Ni buffer layer (7, 7). It was discovered that in high-frequency magnetron mode, silicon carbide is formed in both inert and reactive environments.
Exploring Opportunities and Challenges for the Spread, Scale-Up, and Sustainability of mHealth Apps for Self-Management of Patients With Type 2 Diabetes Mellitus in the Netherlands: Citizen Science Approach
Authors: van Leersum Catharina Margaretha , Bults Marloes , Siebrand Egbert , Olthuis Theodorus Johannes Josef , Bekhuis Robin Enya Marije , Konijnendijk Annemieke Ariënne Johanneke , den Ouden Marjolein Elisabeth Maria 
Published: July 2024

Background
Technologies evolve at a breakneck pace, and the success of mobile health (mHealth) for people with type 2 diabetes mellitus (T2DM) depends on whether health care professionals, care management, government regulators, and consumers will adopt the technology as a viable solution to enhance patient self-management.

Objective
In this study, we explored the challenges of the implementation of mHealth apps in care for patients with T2DM and determined to what extent these challenges complicate the dissemination, limit scale-up, and influence the sustainability of technological interventions for patients with T2DM.

Methods
The nonadoption, abandonment, and challenges to scale-up, spread, and sustainability (NASSS) framework served as the basis for our study. The 7 domains of the NASSS framework were explored with a citizen science approach using questionnaires, semistructured in-depth interviews, and focus groups together with patients with T2DM, care professionals, technology developers, policy officers, and a patient organization.

Results
Regarding the domain “condition,” being aware of their condition and changing lifestyle were crucial for patients with T2DM to get to grips with their life. The rapid development of health apps for T2DM was highlighted in the domain “technology.” Users should be aware of these apps and know how to use them. The domain “value proposition” included the patient perspective and elaborated on personal values, as well as care professionals who focus on personalized care and pressure on health care. Regarding the “adopters,” it is crucial to know who needs to use and introduce the apps. Responsibility, a shared vision, and resistance among care professionals were mentioned as important determinants for “organization.” Finally, the domain “wider system” showed the importance of involving multiple institutes, care guidelines, and reimbursements.

Conclusions
This study investigated the implementation of mHealth apps in an early stage of the implementation process. Key stakeholders were involved, who attributed to the possibilities and limitations of the implementation. It is crucial to have a clear vision from an organizational perspective and specific prerequisites for implementation strategies at micro, meso, and macro levels. Essential strategies at the national level include guidelines for regulations, privacy, and security; the integration of mHealth into T2DM care guidelines; and sufficient reimbursement by health insurers.
PENERAPAN MODEL PEMBELAJARAN SAVI (SOMATIS, AUDITORI, VISUAL, INTELEKTUAL) DALAM PEMBELAJARAN DARING UNTUK MENGUKUR KEMAMPUAN BERPIKIR KRITIS PADA SISWA KELAS IV SEKOLAH DASAR
Authors: Indriani Rian , Rabbani Sylvia , Pratama Deri Fadly 
Published: July 2024

Model pembelajaran SAVI (Somatis, Visual, Auditori dan Intelektual) adalah pembelajaran yang menggabungkan gerakan fisik dengan aktifitas intelektual serta penggunaan semua indera dalam proses pembelajaran. Penelitian bertujuan untuk mengetahui konsep pembelajaran rangka dengan model pembelajaran SAVI (Somatis, Auditori, Visual dan Intelektual) dan untuk mengetahui relevansi model pembelajaran SAVI dengan kemampuan berpikir kritis. Pembelajaran yang dilakukan oleh guru tidak berpusat pada siswa. Pada saat guru melakukan evaluasi sebagaian siswa tidak dapat menjawab soal evaluasi sehingga hasilnya tidak sesuai dengan yang diharapkan. Pada kegiatan belajar khususnya IPA di sekolah dasar, diharapkan guru dapat menggunakan model pembelajaran yang tepat agar konsep yang disampaikan dapat tercapai. Siswa aktif mencari pengetahuan baru dan fasilitator atau mediator dalam pembelajaran. Guru harus terampil merancang aktivitas yang beragam dan memungkinkan siswa terlibat secara penuh dalam pembelajaran. Guru dengan teliti memilih model pembelajaran sebagai kerangka dasar pembelajaran agar tujuan pembelajaran tercapai. Metode Penelitian yang digunakan kualitatif deskriptif karena menggambarkan upaya yang dilakukan oleh guru dalam memperbaiki kualitas pembelajaran gaya dan gerak dengan menggunakan model pembelajaran SAVI.Â Subjek dalam penelitian ini adalah siswa kelas IV SD 179 Sarijadi di Kota Bandung yang berjumlah 25 orang. Hasil penelitian menunjukkan bahwa penerapan pendekatan SAVI dapat meningkatkan hasil belajar IPA materi rangka manusia bagi siswa kelas IIV semester II SDN 179 Sarijadi. Persentase peningkatan hasil belajar IPA pada siswa kelas IV semester IIÂ pada prasiklus hanya 4 siswa atau sebesar 16%, siklus I sebanyak 12 siswa atau sebesar 48%, siklus II sebanyak 20 siswa atau sebesar 80% dan siklus III sebanyak 23 siswa atau sebesar 92%. Hal ini menunjukkan adanya peningkatan hasil belajar IPA sebanyak 19 siswa atau sebesar 76%.Â Pendekatan SAVI dapat memenuhi target pencapaian KKM mata pelajaran IPA materi rangka manusia. Dapat dilihat dari rata-rata pra siklus 44,4, siklus I sebesar 61,4, siklus II sebesarÂ 73,4, dan siklus III sebesar 84,6. Dengan demikian dapat dikatakan bahwa pendekatan SAIVI dapat melampaui KKM sebesar 65. Dapat disimpulkan bahwa hasil tersebut menunjukkan penerapan pendekatan SAVI telah mencapai tujuan penelitian. Sehingga penelitian ini dapat dikatakan berhasil.
Tax Loss Carryforwards and Firm Investments
Authors: Max Malte M. , Wielhouwer Jacco L. , Wiersma Eelke 
Published: July 2024

ABSTRACT
The asymmetric tax treatment of gains versus losses can lead to the creation of a tax loss carryforward (TLCF) in case of prior-period losses. TLCFs shield future income from taxation and can therefore be relevant for investment decisions. The relevance of this tax shield is underlined by the substantial amounts of TLCFs carried forward by U.S. corporations. Despite the theoretically expected positive relation, empirical research on TLCFs and firm-level investments is scarce. We first investigate the TLCF investment relation using simulation analyses and differentiate capital expenditure from R&D expenditure. Our empirical results confirm the positive TLCF investment relation, especially when firms have sufficient financial resources and investment opportunities. Also, the TLCF incentive works differently for capital expenditures compared with R&D. Additional simulation results illustrate how the recent legal changes in carryforward and backward rules affect the investment-enhancing effect of TLCFs and show that it is expected to remain qualitatively comparable.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: H25; H32; M41.
Comparison of Visual Evoked Potential Latency and Amplitude Values According to Visual Acuity among Normal Adult Eyes in dr. Cipto Mangunkusumo Hospital
Authors: Aleddin Rommel , Nusanti Syntia , Shidik Muhammad , Kekalih Aria 
Published: July 2024

Visual Evoked Potential (VEP) is a diagnostic procedure to evaluate pathological conditions affecting the visual pathway with several protocols, including pattern onset/offset VEP, flash VEP, and pattern-reversal VEP (PRVEP), standardized by International Society For Clinical Electrophysiology In Vision (ISCEV). PRVEP, the most common protocol used in clinical practice, is not always directly proportional to visual acuity (VA). Clarity of the refractory media and gender are presumed to affect it; thus, using PRVEP reference value based on refractory status is not casually applicable when the VA does not resemble refractory status. This study aims to determine the changes in VEP latency and amplitude value according to various subjective VA, and to examine and analyze these latency and amplitude values within male and female subject groups. The research was conducted at the Department of Ophthalmology, dr. Cipto Mangunkusumo Hospital from August to October 2017. Latency and amplitude values were measured with PRVEP. Measurement was performed on normal VA and defocus-induced VA to 6/18, 6/30, and 6/60 values, using small and large-sized checkerboard stimuli. Prolonged latency and decreased amplitude were found in male and female subject groups, corresponding with decreasing VA levels. Using 18 min arc and 48 min arc-sized checkerboards gave the closest result to the reference value. The difference in VEP value according to subjects' gender was found in amplitude but not in latency.
Menelisik Kecerdasan Emosional Mahasiswa Aktivis Kampus
Authors: Endah Palupi Gita , Barus Gendon 
Published: July 2024

Kecerdasan emosi (EQ) tidak kalah penting dengan kecerdasan intelektual (IQ). Mahasiswa aktivis kampus dituntut untuk memiliki kecerdasan emosional yang tinggi/baik agar mampu menyeimbangkan berbagai kepentingan dan prioritas sehingga tidak terjebak dalam berbagai konflik. Tujuan penelitian ini adalah mendeskripsikan tingkat kecerdasan emosional mahasiswa aktivis kampus; mengidentifikasi item skala kecerdasan emosional yang capaian skornya rendah/belum optimal; dan menentukan topik pelatihan peningkatan kecerdasan emosi bagi mereka. Penelitian ini menggunakan desain kuantitatif deskriptif . Subjek penelitian berjumlah 47 mahasiswa. Instrumen pengumpulan data menggunakan Skala Kecerdasan Emosional Mahasiswa Aktivis Kampus dengan indeks Cronbach's Alpha sebesar 0,960. Data dianalisis menggunakan statistik deskriptif kategori. Hasil penelitian menunjukkan sebagian besar (51%) mahasiswa aktivis kampus memiliki kecerdasan emosional pada kategori tinggi, 43% pada kategori sangat tinggi, sisanya (6%) pada kategori sedang. Teridentifikasi dua item skala kecerdasan emosional yang capaian skornya belum optimal (4%) menyangkut aspek manajemen diri dan kesadaran diri.
Assessment of Dynamic States of Railway Vehicles: Structural Mathematical Modeling
Authors: Bolshakov R. S. , Gozbenko V. E. , Vuong Quang Truc 
Published: July 2024

Introduction. The speed rise of railway transport and an increase in the loads on the axles of wheelsets necessitate the modernization of the existing fleet. Scientific studies in the field of rolling stock dynamics are aimed at taking into account the oscillatory processes that occur during the movement of railway vehicles in a traditional design. The attachment of supplementary elements was considered at the coupling level of two cars and the attachment of a third trolley in the center of gravity of the railway platform. The scientific literature has not paid enough attention to the construction of mathematical models that make it possible to assess the dynamic states of such constructive solutions. The objective of this study is to create a method for evaluating the dynamic conditions of a car. The situation is considered when an additional set of mass-inertial and elastic elements is introduced into its structure, and the general dynamic condition of the vehicle depends on the adjustment of their parameters.Materials and Methods. The basic research tool is the structural mathematical modeling, which is based on an approach where the source design scheme is a mechanical oscillatory system in the form of a solid body on elastic supports with supplementary typical elements introduced into its structure. The dynamic analogue of the calculation scheme used is the block diagram of the automatic control system, the use of which provides detailing the connections between typical elastic and mass-inertia elements.Results. A method for estimating the dynamic states of railway vehicles is proposed. It is based on the construction of mathematical models, taking into account the introduction of an additional structure of mass-inertia and elastic elements. The impact of additional parameters on the dynamic condition of the vehicle is investigated. Analytical relations have been obtained that provide reducing the dynamic loads on the major structural elastic elements when changing the corresponding parameters of a technical object. The transfer function of interpartial relations is given, which provides controlling the interaction between the coordinates of the vehicle movement under the action of two kinematic disturbances of the in-phase type.Discussion and Conclusion. The generated mathematical model provides for assessment, monitoring and control of the dynamic state of the vehicle under conditions of kinematic disturbances. The research results can be used to modernize existing vehicles and create new ones with improved dynamics.
PENGARUH PEMBERIAN REWARD DAN PUNISHMENT TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN IPAS KELAS V SD NEGERI 023972 KECAMATAN BINJAI KOTA T.A 2023/2024
Authors: Monica Cindy , Tambunan Husna Parluhutan 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian reward dan punishment terhadap hasil belajar siswa kelas V SD Negeri 023972 Kecamatan Binjai Kota T.A 2023/2024. Populasi penelitian ini adalah seluruh siswa kelas V berjumlah 40 siswa. Sampel yang digunakan dalam penelitian ini adalah sampling jenuh dalam hal ini peneliti mengambil semua anggota populasi untuk dijadikan sampel. Pada penelitian ini peneliti menggunakan penelitian eksperimen metode Quasi Experimental Design, dimana penelitiannya tidak dapat memberikan kontrol penuh, dengan menggunakan desain Nonequivalent Control Group Design. Hasil penelitian ini menunjukkan bahwa “Terdapat pengaruh pemberian reward dan punishment terhadap hasil belajar siswa pada mata pelajaran IPA dan IPA siswa kelas V SDN 023972 Wilayah Kota Binjai TA 2023/2024”.
DECONSTRUCTING INDUSTRIAL REVOLUTION 4.0 DISCOURSE IN EDUCATIONAL INEQUALITY IN INDONESIA
Authors: Ramadhan Moch. Gilang , Setiadi Elly Malihah , Nurbayani Siti 
Published: July 2024

Research with the topic of deconstructing industrial revolution 4.0 discourse is become important to provide awareness that except spiritual concepts, absolute truth cannot exist. In the discourse of Industrial Revolution 4.0, we must see the truth as separated fragments. The discourse of the industrial revolution 4.0, is born and forced to become a new regime of truth in society. Knowledge and enthusiasm regarding the discourse of the industrial revolution 4.0 which is disseminated systematically and then manifested into regulations actually curbs people's way of thinking. Therefore, this research aims to examining overlooked meanings, or even presenting a different perspective with critical analysis regarding industrial revolution discourse in education. And also revise the facts behind the belief and enthusiasm for the industrial revolution 4.0 discourse. This research uses a qualitative approach, with a literature study method, so that data is obtained through reviewing various scientific journals related to the research theme. Research findings show 1) industrial revolution 4.0 discourse was formed because the state positioned education as an opportunity for economic activity, which then had to be adapted and lead to children's investment in the future through education, 2) The delegation of quality education to the private sector and the reduced role of the state are caused by neoliberal discourse. Problems then arise when the discourse on industrial revolution 4.0 actually ignores the right to an equitable and prosperous life and further sharpens inequality in society, 3) Each social class has different habits (habitus) to respond to readiness for the industrial revolution 4.0. Starting from media ownership and access to learning, to family cultural factors and the absence of the state in important areas of learning.