bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipocytes impact on gastric cancer progression: Prognostic insights and molecular features
Authors: Shang Jia-Rong , Zhu Jin , Bai Lu , Kulabiek Delida , Zhai Xiao-Xue , Zheng Xia , Qian Jun 
Published: July 2024

BACKGROUND
Adipocytes, especially adipocytes within tumor tissue known as cancer-associated adipocytes, have been increasingly recognized for their pivotal role in the tumor microenvironment of gastric cancer (GC). Their influence on tumor progression and patient prognosis has sparked significant interest in recent research. The main objectives of this study were to investigate adipocyte infiltration, assess its correlation with clinical pathological features, develop a prognostic prediction model based on independent prognostic factors, evaluate the impact of adipocytes on immune cell infiltration and tumor invasiveness in GC, and identify and validate genes associated with high adipocyte expression, exploring their potential diagnostic and prognostic value.
AIM
To explore the relationship between increased adipocytes within tumor tissue and prognosis in GC patients as well as the associated mechanisms and potential biomarkers, using public databases and clinical data.
METHODS
Using mRNA microarray datasets from the Gene Expression Omnibus database and clinical samples from Jiangsu Provincial Hospital, survival and regression analyses were conducted to determine the relevant prognostic factors in GC. Feature gene selection was performed using least absolute shrinkage and selection operator and support vector machine recursive feature elimination algorithms, followed by differential gene expression analysis, gene ontology, pathway analysis, and Gene Set Enrichment Analysis. Immune cell infiltration was analyzed using the CIBERSORT algorithm.
RESULTS
Tumor adipocyte infiltration correlated with poor prognosis in GC, leading to the development of a highly accurate and discriminative prognostic prediction model. Key genes, ADH1B , SFRP1 , PLAC9 , and FABP4 , were identified as associated with high adipocyte expression in GC. The diagnostic and prognostic potential of these identified genes was validated using independent datasets. Downregulation of immune cells was observed in GC with high adipocyte expression.
CONCLUSION
GC with high intratumoral adipocyte expression demonstrated aggressive tumor biology and a poorer prognosis. The genes ADH1B , SFRP1 , PLAC9 , and FABP4 have been identified as holding diagnostic and prognostic significance in GC. These findings strongly support the use of adipocyte expression as a valuable indicator of tumor invasiveness and anticipated patient outcomes in GC.
Nicotine-impaired cognitive and psychosocial behavior and spatial memory deficit: The combined roles of garlic cloves and honey in Wistar rats.
Authors: Uchewa O.O. , Okechukwu N.G. , Kenneth U.G. , Okoronkwo O.S. , Ibegbu O.A. , Cookey-Gam B.T. , Anyigor O.O. , Nwofia O.J. 
Published: July 2024

BACKGROUND AND AIM: Nicotine is an additive abused among youths, which gradually becomes behavioral. The aim of this study was to investigate the ameliorative roles of aqueous garlic cloves and honey extract on nicotine-induced cognitive, spatial memory, and psychosocial behavior impairments.
METHODOLOGY: Forty rats were divided into 5 groups of eight. Group A served as control, receiving food and water. All the groups except A received 50mg/kg of nicotine for 14 days. Group B served as the nicotine-untreated group; Group C received 200mg/kg of garlic and 1000mg/kg of honey; Group D received 400mg/kg body weight of garlic and 1500mg/kg of honey; and Group E received 600mg/kg of garlic and 2000mg/kg of honey. Garlic and honey treatment lasts 14 days. Spatial memory, anxiety, social behavior, and cognition were measured using the Morris Water Maze (MWM), elevated plus maze, sociability chamber, and novel object recognition test. Brain homogenate was used to determine biomarkers.
RESULTS: The acquisition latency was significantly decreased in the high-dose compared to the nicotine-untreated on day 4 of the MWM test at p < 0.05. The discrimination index reduced significantly in the high-dose group compared to the nicotine untreated at p < 0.05. The time spent with both novel rats significantly increased in the nicotine-untreated group and was lowered by the garlic clove extract. Glutathion-S-Transferase (GST), glutathione oxaloacetate (GOT), and Thiobarbituric Acid Reacting Substances (TBARS) were significantly reduced in the garlic extract groups at P<0.05.
CONCLUSION: Garlic cloves and honey enhanced brain cell regeneration, improved spatial memory, cognition, and social behaviors, and decreased anxiety.
Evaluation of efficacy of Avipattikar churna versus Chitrakadi kwath in the management of Amlapitta (Hyperacidity) - A pilot study
Authors: Gaikwad Ishwari , Misar Wajpeyi Sadhana 
Published: July 2024

Amlapitta is a condition characterised by the predominance of Pitta and is associated with the Annavaha and Purishvaha srotas. It manifests as a result of imbalances in Mandagni (weakened digestive fire) and the presence of Ama (undigested or improperly metabolized substances). The prevalence rate of Amlapitta in India is 38.1%. Considering the similarities in etiopathogenesis, it can be correlated with Hyperacidity in Modern Science. Aim and Objectives: To evaluate the efficacy of Avipattikar churna versus Chitrakadi kwath in the management of Amlapitta (Hyperacidity). Methodology: An Interventional Study was conducted among 30 patients between the ages of 20 and 60 of either sex who had symptoms of Tikta Amlodgar (sour and bitter irructation), Hrit-kanthadaha (burning in heart and throat), Udarashool (epigastric pain) and Utklesha (nausea), and Aruchi (anorexia). Group A was given Aipattikar Churna; Group B was given Chitrakadi Kwath. Subjective Parameters were assessed in both groups on the 0th, 7th, and 15th days, and comparison was done by statistical analysis. Observation and Discussion: Both interventions proved effective, showcasing strengths in addressing distinct subjective parameters. Conclusion: Both drugs demonstrated high effectiveness in the study. Group A exhibited significant improvements across all subjective parameters, except Udarshoola (Abdominal pain). On the other hand, Group B displayed notable results in all subjective parameters, except for Utklesha and Aruchi. In conclusion, both groups were significant.
Combate à escravização: uma reflexão sobre a ética Espinosana
Authors: Sudano Suliane 
Published: July 2024

O artigo apresenta estudo de cunho social e filosófico sobre o tema da escravidão contemporânea. São comparadas abordagens de estudiosos do tema, no sentido de compreender os fatores que obstaculizam o combate. Tomando como base dados sobre a escravidão contemporânea no Brasil e no mundo, torna-se plausível a busca por elementos internos e, também, externos às relações de escravização, como as relações no âmbito da sociedade e do Estado. Estas estão constantemente legitimando ou não práticas escravagistas. Enfatiza-se a importância das investigações de aspectos objetivos, subjetivos e intersubjetivos no intuito de aprofundamento do problema. Inicia-se o artigo com apresentação de teóricos do tema da escravidão, sinalizando traços de convergência com o fenômeno do trabalho escravo contemporâneo. Em um segundo momento, apresentam-se elementos da filosofia de Baruch Espinosa, como via de reflexão sobre a qualificação dos discursos para o combate às práticas escravagistas.
EGRA Teachers’ Capacity-Building Interventions on Reading Abilities of Early Grade Learners in Public Primary Schools in Kiambu County, Kenya
Authors: Thuo Zipporah Wanjiku , Ronoh Alexander , Tanui Edward 
Published: July 2024

Early Grade Reading activities is an initiative implemented in Kenya with the aim of improving reading among learners in grades one to three. This programme encompasses various interventions. This study sought to investigate the influence of the Early Grade Reading Activities (EGRA) teachers’ capacity-building interventions on the reading abilities of learners in public primary schools in Kiambu County. The specific objective of the study was to examine the influence of teachers’ capacity-building interventions on reading abilities of early grade learners in public primary schools in Kiambu County.The study utilized the descriptive survey research design The study was guided by the Vygotsky’s Socio-cultural Cognitive Development Theory. The target population was 26,156 individuals from the 576 public primary schools in Kiambu county. This population comprised 1,408 grade one to three teachers and 24,748 grade 3 learners in the public primary schools in Kiambu County. A sample of 1066 individuals comprising of 57 lower grade teachers and 1009 grade 3 learners were selected using the cluster sampling technique. Teacher’s Questionnaire were used to collect data from the teachers while an achievement test was used to collect data from learners. Data were analysed using frequencies, percentages, means, and standard deviation while the linear regression method was used to test the relationships between variables. Results showed that teachers’ capacity building (β= 0.474, t= 4.055, p<.001) had a positive and statistically significant influence on learners reading abilities. The study concludes that interventions that seek to build teacher capacity are effective in improving early grade reading abilities. This information could be of great significance in designing future programmes that reflect good practices and implementation. The study recommends that the Ministry of Education should sustain EGRA teachers’ capacity building approaches at the end of the EGRA programme.
THE RELEVANCE OF THE STUDY AND THE PROBLEMS OF THE DEVELOPMENT OF HYDROMINERAL RAW MATERIALS IN THE RUSSIAN FEDERATION
Authors: Михеева Е.Д. , Кузьменко П.С. 
Published: July 2024

Озвучена актуальность изучения гидроминерального сырья. Рассмотрены перспективные объекты гидроминерального сырья в России. Представлены содержания лития и попутных компонентов в соляных озерах. Приведены основные проблемы освоения перспективных проявлений и площадей.
The urgency of the study of hydro-mineral raw materials is voiced. Promising objects of hydro-mineral raw materials in Russia are considered. Contents of lithium and associated components in salt lakes are presented. The main problems of development of promising manifestations and areas are given.
GEOLOGICAL AND STRUCTURAL POSITION AND SOURCES OF FORMATION OF THE JALINDINSKY UNIQUE PLACER SYSTEM OF THE PRIAMUR GOLD-BEARING PROVINCE
Authors: Степанов В.А. , Мельников А.В. 
Published: July 2024

Приведены сведения о крупной Джалиндинской россыпной системе Приамурской золотоносной провинции, которая расположена в Соловьевском рудно-россыпном узле Янканской металлогенической зоны Приамурской золотоносной провинции. Из россыпей этой системы добыто около 200 т золота, что составляет 24 % извлеченного россыпного золота провинции. Дана характеристика россыпей, в том числе уникально богатой россыпи р. Джалинда. Установлено, что источником формирования россыпей является штокверк многочисленных золотоносных кварцевых жил, зон прожилкового окварцевания и кварцевых прожилков, размером 15×20 км, приуроченный к Джалиндинской гранитоидной интрузии раннемелового возраста. Приведено описание расположенных в пределах штокверка Кировского и Соловьевского золоторудных месторождений золотосульфидно-кварцевой формации.
Information is given about the large Jalindin placer system of the Amur gold-bearing province, which is located in the Solovyov ore-placer node of the Yankan metallogenic zone of the Amur gold-bearing province. About 200 tons of gold were extracted from placers of this system, which is 24% of the extracted placer gold of the province. The characteristic of placers, including the uniquely rich placer of the Jalinda river, is given. It has been established that the source of placer formation is a stockwork of numerous gold-bearing quartz veins, zones of veined quartz formation and quartz veins, measuring 15×20 km, dated to the Jalindin granitoid intrusion of Early Cretaceous age. The description of the Kirovsky and Solovyevsky gold ore deposits located within the stockwork of the gold-sulfide-quartz formation is given.
Pelatihan Sistem Evaluasi Pembelajaran PAI Guna Meningkatkan Minat dan Motivasi Belajar Siswa Sekolah Menengah Atas
Authors: Safaruddin Safaruddin , Mutmainnah Mutmainnah , Tahir Nurya , Iftika Nurul , Juhaeni Juhaeni 
Published: July 2024

Pelaksanaan evaluasi merupakan inti dari pelaksanaan pembelajaran dan suatu keharusan untuk dilakukan serta menjadi catatan penting guna memetakan capaian siswa dalam proses pembelajaran dan memberikan umpan balik kepada siswa. Strategi ice breaking yang melibatkan evaluasi materi yang diberikan dapat digunakan untuk meningkatkan minat dan motivasi belajar. Oleh karena itu peneliti mengadakan pelatihan sistem evaluasi pembelajaran PAI untuk meningkatkan minat dan motivasi belajar siswa di SMA Negeri 1 Sinjai. Adapun tujuan yang akan dicapai melalui pelatihan ini diantaranya: (1) Meningkatkan pemahaman dan kemampuan melaksanakan kegiatan belajar mengajar untuk menumbuhkan motivasi belajar siswa kelas X.1 di SMA Negeri 1 Sinjai; (2) Siswa diharapkan terampil aktif dalam pelaksanaa Evaluasi pembelajaran di kelas; (3) menumbuhkan minat dan motivasi belajar siswa di SMA Negeri 1Sinjai. Pelatihan ini menggunakan metode Service Learning yang terdiri dari tiga tahap yaitu: tahap persiapan, tahap pelaksanaan dan tahap refleksi. Adapun Solusi yang diajukan peneliti terletak pada penilaian dan motivasi siswa, peningkatan minat dan motivasi belajar. Hasil penelitian menunjukkan bahwa siswa lebih tertarik dan termotivasi dalam belajar dari awal hingga akhir.
Hubungan Penerapan Perilaku Cuci Tangan dan Jajanan Sehat dengan Kejadian Diare pada Anak Usia Sekolah Dasar Kelas IV di SDN Kalibaru 03 Kota Depok Tahun 2022
Authors: Utami Indah Tri , Rukyah Nining , Lestari Nur Eni 
Published: July 2024

Latar Belakang: Diare adalah pengeluaran feses yang konsistensinya lembek sampai cair dengan frekuensi pengeluaran feses sebanyak 3 kali atau lebih dalam sehari. Faktor pencegahan diare adalah dengan mencuci tangan dan membeli jajanan sehat.
Tujuan: Untuk mengetahui hubungan penerapan perilaku cuci tangan dan jajanan sehat dengan kejadian diare pada anak usia sekolah dasar kelas IV di SDN Kalibaru 03 Kota Depok Tahun 2022.
Metode: Jenis penelitian ini kuantitatif dengan pendekatan Cross-Sectional, populasi dalam penelitian ini merupakan siswa kelas IV SDN Kalibaru 03 sebanyak 128 siswa sedangkan sampel yang digunakan sebanyak 56 orang yang diambil menggunakan teknik probability sampling. Instrumen pengumpulan data menggunakan kuesioner kemuadian analisis data menggunakan analisis univariat dan analisis bivariat dengan uji statistik chi-square.
Hasil: Berdasarkan hasil uji statistik pada hubungan antara perilaku cuci tangan dengan kejadian diare didapatkan nilai P-Value 0,013 < 0,05.
Kesimpulan: Hasil Penelitian menunjukkan masih banyak siswa/i yang lalai terhadap kebersihan diri sendiri dan lingkungan yang menyebabkan banyaknya siswa/i yang mengalami diare. Dari hasil penelitian dapat disimpulkan bahwa terdapat hubungan signifikan antara jajanan sehat dengan kejadian diare di SDN Kalibaru 03.
Kata Kunci : Perilaku cuci tangan, jajanan sehat, kejadian diare
Refleksi Teologis Pendidikaan Kristen Berdasarkan Amsal 22:6 Terhadap Tantangan Sosial yang dihadapi Generasi Z
Authors: Ginting Saronisa 
Published: July 2024

If viewed logically, generation Z focuses on various problems, the problems that arise in generation Z have an impact on multidimensional, psychological, social, communication, moral, and spiritual problems, so that theological values really need to be fulfilled by the younger generation. generations to keep their behavior in check. life. To find answers, the research method used is descriptive qualitative using literature sources, while the discussion starts from the understanding of generation z, social phenomena faced by generation z, and reflection on Christian education theology based on Proverbs 22:6, and it is said that Christian education is not can be separated. from a Christian family, and parents must realize family Christian education from an early age.Keywords: generation z, christian education, technology, social challenges AbstrakJika dicermati secara logika, generasi Z nampaknya rentan dengan berbagai permasalahan, permasalahan yang muncul pada generasi Z berdampak pada multi dimensional yaitu permasalahan psikologis, sosial, komunikasi, moral, dan spiritual, nilai-nilai teologis sangat perlu dibenahi. dipahami oleh generasi muda untuk menjaga keseimbangan dalam perilaku mereka dalam kehidupan. Untuk menemukan jawaban, metode penelitian yang digunakan adalah metode deskriptif kualitatif dengan menggunakan sumber-sumber literatur, sedangkan pembahasannya dimulai dari pemahaman generasi z, mengkaji fenomena sosial yang dihadapi generasi z, dan merenungkan teologi pendidikan Kristen berdasarkan Amsal 22:6, dan disimpulkan bahwa pendidikan Kristen tidak dapat dipisahkan dari keluarga Kristen, dan orang tua harus mewujudkan pendidikan keluarga Kristen sejak dini.Kata Kunci: generasi z, pendidikan kristen, teknologi, tantangan sosial
Sovereignty of the Russian ruble as a condition of national security
Authors: Голоскоков Л.В. 
Published: July 2024

В статье исследованы некоторые аспекты национальной безопасности, связанные с российским рублём, его устойчивостью, привлекательностью, способностью обеспечить рост индустрии, производства, всё более полное удовлетворение материальных и духовных потребностей российских граждан, привлекательность для иностранных граждан и инвесторов. Рассмотрены риски ослабления национальной безопасности из-за изменения состояния рубля, его формы (бумажной, цифровой). Изучены глубинные условия стабильности рубля и предложены возможные решения для его укрепления.
The article examines some aspects of national security related to the Russian ruble, its stability, attractiveness, ability to ensure the growth of industry, production, increasing satisfaction of the material and spiritual needs of Russian citizens, and attractiveness for foreign citizens and investors. The risks of weakening national security due to changes in the state of the ruble and its form (paper, digital) are considered. The underlying conditions of ruble stability are studied and possible solutions for its strengthening are proposed.
Copies and images of documents as a source of obtaining evidentiary information
Authors: Купин А.Ф. 
Published: July 2024

В статье на основе анализа нормативных правовых актов определено юридическое значение, порядок получения и использования в официальном документообороте и уголовном судопроизводстве копий документов как источника получения доказательственной информации, разъяснены некоторые особенности, которые необходимо учитывать при использовании их в доказывании. Исходя из результатов изучения материалов следственной, судебной и экспертной практики, описаны возможности, а также порядок назначения и особенности производства судебных экспертиз, объектами которых являлись изображения рукописей в копиях бумажных документов, а также изображения рукописей в копиях, сохраненных в виде файлов различного формата на машинных носителях информации. С учетом механизма, а также порядка и условий изготовления копий документов перечислены факторы и обстоятельства, на которые необходимо обращать внимание сотрудникам правоохранительных органов и суда при оценке результатов судебных экспертиз, посвященных исследованию изображений рукописей в копиях бумажных документов, а также изображений рукописей в копиях, сохраненных в виде файлов различного формата на машинных носителях информации.
Based on the analysis of laws, the article defines the legal significance, the procedure for obtaining and using copies of documents as a source of obtaining evidentiary information in official document circulation and investigations. Founded on the results of the study of materials of investigative, judicial and expert practice the possibilities, as well as the order of appointment and peculiarities of production of forensic examinations, which objects were images of manuscripts in paper copies or images of manuscripts in copies saved as files of various formats on machine data carriers, are described. On the basis of the mechanism, order and conditions of making copies of documents the factors and circumstances – in which it is necessary to pay attention when evaluating the results of forensic examinations devoted to the study of images of manuscripts in paper copies or images of manuscripts in copies saved as files of various formats on machine data carriers, are described.
On the concept of bribery in criminal law
Authors: Апкаев Д.М. 
Published: July 2024

Современное общество представляет собой совокупность отношений между людьми, а также регуляторов таких отношений. В свою очередь, последние могут иметь социальный, религиозный или правовой характер. Нормы права, выступающие именно правовым регулятором, устанавливают меру должного или возможного поведения. В многообразии общественных отношений встречаются такие ситуации, когда установленная нормой права мера поведения не устраивает конкретного человека в конкретной ситуации, в связи с чем он пытается достичь противозаконного согласия с соответствующими контролирующими органами в пользу своих интересов. Указанное явление определяется термином «взяточничество». Поскольку оно имеет отрицательный и деструктивный характер, необходимым элементом государственной политики является борьба с этим явлением. Очевидно, что такая борьба должна иметь правовой характер, что заключается в законодательном определении сторон взяточничества, установлении запрета на его совершение и осуществлении уголовного преследования лиц, преступивших такой запрет.
Modern society is a set of relations between people, as well as regulators of such relations. In turn, the latter may have a social, religious or legal character. The norms of law, acting precisely as a legal regulator, establish the measure of proper or possible behavior. In the diversity of public relations, there are situations when the measure of behavior established by the rule of law does not suit a particular person in a particular situation, and therefore he is trying to reach an illegal agreement with the relevant regulatory authorities in favor of his interests. This phenomenon is defined by the term “bribery”. Since it has a negative and destructive character, a necessary element of state policy is the fight against this phenomenon. It is obvious that such a struggle should have a legal character, which consists in the legislative definition of the parties to bribery, the establishment of a ban on its commission and the prosecution of persons who have violated such a ban.