bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the Shadows: An Exploratory Analysis of Perceived Disadvantages in Intimate Relationships
Authors: Apostolou Menelaos , Iniati Eleni , Charalambous Andrea , Zalaf Alexia , Kagialis Antonios 
Published: June 2024

AbstractIntimate relationships are not characterized only by advantages as they have also a darker side. Accordingly, the current research aimed to identify the disadvantages of being in an intimate relationship in the Greek cultural context. More specifically, Study 1 employed qualitative research methods with a sample of 202 Greek-speaking participants, identifying 94 possible disadvantages. Study 2 employed quantitative research methods with a sample of 525 Greek-speaking participants and classified these disadvantages into 11 broader factors or major disadvantages and three broader domains or primary disadvantages. Participants indicated "Conflicts" as the most important primary disadvantage, followed by the "Emotional burden" and the "Compromises" primary disadvantages. Furthermore, we found that women indicated abusive behaviors, economic dependency, and less freedom factors as more important major disadvantages than men. Additionally, older participants reported making compromises as a more important major disadvantage than younger participants. Moreover, single participants rated several major disadvantages as more important than participants in an intimate relationship. Overall, our study sheds light on the less favorable aspects of intimate relationships and highlights important sex, age, and relationship status differences in perceiving these disadvantages.
Multi-layered metabolic effects of trehalose on the liver proteome in apoE-knockout mice model of liver steatosis
Authors: Pogoda Weronika , Koczur Jakub , Stachowicz Aneta , Madej Józef , Olszanecki Rafał , Suski Maciej 
Published: June 2024

Abstract
Background
Metabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of atherosclerosis. A growing body of evidence suggests that due to its numerous favorable molecular effects, trehalose may exert beneficial effects in counteracting liver steatosis. In our previous study, we described the antiatherosclerotic and antisteatotic properties of trehalose, which we attributed to the induction of autophagy. Considering the pleiotropic activities of trehalose, our present study aimed to extend our preliminary results with the comprehensive examination of proteome-wide changes in the livers of high-fat-fed apoE-/- mice.

Methods
Thus, we applied modern, next-generation proteomic methodology to comprehensively analyze the effects of trehalose on the alterations of liver proteins in apoE-/- mice.

Results
Our proteomic analysis showed that the administration of trehalose elicited profound changes in the liver proteome of apoE-/- mice. The collected data allowed the identification and quantitation of 3 681 protein groups of which 129 were significantly regulated in the livers of trehalose-treated apoE-/- mice.

Conclusions
The presented results are the first to highlight the effects of disaccharide on the induction of proteins mainly related to the metabolism and elimination of lipids, especially by peroxisomal β-oxidation. Our study provides evidence for the pleiotropic activity of trehalose, extending our initial observations of its potential mechanisms responsible for mitigating of liver steatosis, which paves the way for new pharmacological strategies in fatty liver disease.
Efficiency increased advanced oxidation processes by persalts for the elimination of pharmaceuticals in waterbodies: a short review
Authors: Voigt Melanie , Jaeger Martin 
Published: June 2024

AbstractTo achieve complete elimination of anthropogenic micropollutants in aquatic environments, advanced oxidation processes are intensively researched as remedies and potential advanced purification stages in wastewater treatment facilities. Persalts, like persulfates, percarbonates and periodates, have been investigated as potential accelerators or enhancers of these processes. This short review provides an overview of the efficiency of the persalts demonstrated for the degradation of the seven most frequently occurring pharmaceuticals in the aquatic environment: carbamazepine, ciprofloxacin, diclofenac, ibuprofen, metoprolol, paracetamol and sulfamethoxazole. While persulfates were the most commonly used, all persalts increase the effectiveness of the degradation of the pharmaceutical contaminants by increasing the formation of hydroxyl radicals, especially in the case of sodium percarbonate. Persalts are efficiently activated through UVC irradiation. The generated hydroxyl radicals are the main factor for product formation and hence dominate the chemical structures of the transformation products. From the ecotoxicological perspective, the use of persalts causes little or no hazard, if the conditions are such that acidification can be neglected. While they are transformed to stable anions on reaction, the resulting transformation products of the anthropogenic micropollutants were predicted by quantitative structure activity relation analysis to possess lower ecotoxicity than the initial drugs.
The effect of biochar on crop productivity and soil salinity and its dependence on experimental conditions in salt-affected soils: a meta-analysis
Authors: Wu Baolin , Yang Heng , Li Siyuan , Tao Jun 
Published: June 2024

AbstractBiochar can significantly alter soil properties and therefore can play an important role in increasing the resilience of agricultural systems to salt conditions. To match biochar to salt-affected soil constraints and application needs, a thorough understanding of the impact of biochar, soil properties and experimental conditions on crop productivity and soil salinity is necessary. This meta-analysis (MA) of the available literature for the first time quantitatively assessed the effect of not only biochar applied to salt-affected soils but also that of different salt-affected soil properties on crop productivity and soil salinity. The results showed that biochar was most effective at improving crop productivity in salt-affected soils, with an application rate ranging from 40–50 t/ha, a C/N ratio ranging from 40–60, a pyrolysis temperature ranging from 450–550 °C and a pH ranging from 7–8. Biochar with an EC of < 2 mS/cm, an application rate of 20–30 t/ha, a C/N ratio of > 80 t/ha or a pyrolysis temperature of < 450 °C reduced the soil salinity. Regardless of climatic and soil conditions, biochar applied to salt-affected soils increased crop productivity under different climatic conditions. Biochar increased soil salinity under different temperature and soil pH conditions and decreased soil salinity in salt-affected soils treated with all types of salts. Biochar was most effective at improving crop productivity and soil salinity in sulfate-dominated saline soils. Regardless of the planting and management practices, biochar increased crop productivity in salt-affected soils. The combined application of biochar and inorganic fertilizer significantly increased crop productivity and kept soil salinity unchanged. This meta-analysis provides the first quantitative review of the effect of biochar on crop productivity and soil salinity in salt-affected soils, which is critical for developing engineered biochar to restore salt-affected soils and promote food security.
Graphical Abstract
The Dynamics of the India‐Eurasia Collision: Faulted Viscous Continuum Models Constrained by High‐Resolution Sentinel‐1 InSAR and GNSS Velocities
Authors: Fang Jin , Houseman Gregory A. , Wright Tim J. , Evans Lynn A. , Craig Tim J. , Elliott John R. , Hooper Andy 
Published: June 2024

AbstractThe distribution and magnitude of forces driving lithospheric deformation in the India‐Eurasia collision zone have been debated over many decades. Here we test a two‐dimensional (2‐D) Thin Viscous Shell approach that has been adapted to explicitly account for displacement on major faults and investigate the impact of lateral variations in depth‐averaged lithospheric strength. We present a suite of dynamic models to explain the key features from new high‐resolution Sentinel‐1 Interferometric Synthetic Aperture Radar as well as Global Navigation Satellite System velocities. Comparisons between calculated and geodetically observed velocity and strain rate fields indicate: (a) internal buoyancy forces from Gravitational Potential Energy acting on a relatively weak region of highest topography (>2,000 m) contribute to dilatation of the high plateau and contraction on the margins; (b) a weak central Tibetan Plateau (∼1021 Pa s compared to far‐field depth‐averaged effective viscosity of at least 1022–1023 Pa s) is required to explain the observed long‐wavelength eastward velocity variation; (c) localized displacement on fault systems enables strain concentration and clockwise rotation around the Eastern Himalayan Syntaxis. We discuss the tectonic implications for rheology of the lithosphere, distribution of geodetic strain, and partitioning of active faulting and seismicity.
Early reappearance of intraclonal proliferative subpopulations in ibrutinib-resistant chronic lymphocytic leukemia
Authors: Pozzo Federico , Forestieri Gabriela , Vit Filippo , Ianna Giulia , Tissino Erika , Bittolo Tamara , Papotti Robel , Gaglio Annalisa , Terzi di Bergamo Lodovico , Steffan Agostino , Polesel Jerry , Bulian Pietro , Laureana Roberta , Tafuri Agostino , Chiarenza Annalisa , Di Raimondo Francesco , Olivieri Jacopo , Zaja Francesco , Laurenti Luca , Del Principe Maria Ilaria , Postorino Massimiliano , Del Poeta Giovanni , Bomben Riccardo , Zucchetto Antonella , Rossi Davide , Gattei Valter 
Published: June 2024

AbstractThe Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib represents an effective strategy for treatment of chronic lymphocytic leukemia (CLL), nevertheless about 30% of patients eventually undergo disease progression. Here we investigated by flow cytometry the long-term modulation of the CLL CXCR4dim/CD5bright proliferative fraction (PF), its correlation with therapeutic outcome and emergence of ibrutinib resistance. By longitudinal tracking, the PF, initially suppressed by ibrutinib, reappeared upon early disease progression, without association with lymphocyte count or serum beta-2-microglobulin. Somatic mutations of BTK/PLCG2, detected in 57% of progressing cases, were significantly enriched in PF with a 3-fold greater allele frequency than the non-PF fraction, suggesting a BTK/PLCG2-mutated reservoir resident within the proliferative compartments. PF increase was also present in BTK/PLCG2-unmutated cases at progression, indicating that PF evaluation could represent a marker of CLL progression under ibrutinib. Furthermore, we evidence different transcriptomic profiles of PF at progression in cases with or without BTK/PLCG2 mutations, suggestive of a reactivation of B-cell receptor signaling or the emergence of bypass signaling through MYC and/or Toll-Like-Receptor-9. Clinically, longitudinal monitoring of the CXCR4dim/CD5bright PF by flow cytometry may provide a simple tool helping to intercept CLL progression under ibrutinib therapy.
Highly conductive polymer electrodes for polymer light-emitting diodes
Authors: Xu Jin , Du Ke , Peng Feng , Sun Zhenzhong , Zhong Zhiming , Feng Weiji , Ying Lei 
Published: June 2024

AbstractOrganic light-emitting diodes (OLEDs) offer the advantage of flexibility; however, the use of traditional transparent anode ITO limits further extension of their flexible characteristics. In this study, we propose employing an polymer polybenzodifuranedione (PBFDO) as a flexible transparent anode instead of the rigid ITO. To address the issue encountered during the PBFDO solution spin-coating process, we introduced n-butanol into the PBFDO conductive solution to reduce its viscosity and freezing point by modulating intermolecular hydrogen bonding interactions. Consequently, high-quality PBFDO films with high conductivity, superior transmittance, and low surface roughness were successfully obtained via spin-coating. Moreover, due to its proper work function, regular molecular stacking, and low refractive index properties, PBFDO electrode facilitate efficient carrier injection and transport as well as photon extraction. The resulting device utilizing a PBFDO anode combined with Super Yellow as the light-emitting layer exhibited excellent performance characteristics including a normal threshold voltage of 2.6 V and a maximum luminous efficiency of 12.8 cd A−1 comparable to that device based on the ITO electrode. Furthermore, flexible device also achieved satisfactory performance (7.7 cd A−1) when using the PEN substrate.
Photodecoration of tungsten oxide nanoparticles onto eggshell as an ultra-fast adsorbent for removal of MB dye pollutant
Authors: Dadashi Reza , Bahram Morteza , Farhadi Khalil , Asadzadeh Zartosht , Hafezirad Javad 
Published: June 2024

AbstractNowadays, the use of natural wastes and adsorbents along with their modification by simple and new methods based on metal oxides to remove dye pollutants has been the focus of many researchers. In this study, for the first time, simple and low-cost modification of eggshell (EGS) with tungsten oxide (WO3) based on the photochemical modification method as a green, ultra-fast, cost-effective, and biodegradable adsorbent is reported to remove of methylene blue (MB) dye pollutant. The EGS modified by WO3 was investigated by EDX, EDX mapping, XRD, FE-SEM, and UV–Vis Diffuse Reflectance (DRS) analyses. The obtained results show that the modified EGS by WO3 has more than ten times (78.5%) the ability to remove MB dye pollutant within 3 min compared to bare EGS (11%). Various parameters including dye pollutant pH, dye concentration, adsorbent dosage, and reusability of the WO3/EGS adsorbent for removal of MB dye pollutant were investigated and the result show that the adsorbent capacity of WO3/EGS is 1.64 mg g−1. EGS adsorbent The synthesis of WO3/EGS adsorbent with a novel photochemical method as a fast and very cheap adsorbent with excellent efficiency can be a promising alternative adsorbent for various purposes in removing dye pollutants from water environments.
The Arabidopsis AtSWEET13 transporter discriminates sugars by selective facial and positional substrate recognition
Authors: Weigle Austin T. , Shukla Diwakar 
Published: June 2024

AbstractTransporters are targeted by endogenous metabolites and exogenous molecules to reach cellular destinations, but it is generally not understood how different substrate classes exploit the same transporter’s mechanism. Any disclosure of plasticity in transporter mechanism when treated with different substrates becomes critical for developing general selectivity principles in membrane transport catalysis. Using extensive molecular dynamics simulations with an enhanced sampling approach, we select the Arabidopsis sugar transporter AtSWEET13 as a model system to identify the basis for glucose versus sucrose molecular recognition and transport. Here we find that AtSWEET13 chemical selectivity originates from a conserved substrate facial selectivity demonstrated when committing alternate access, despite mono-/di-saccharides experiencing differing degrees of conformational and positional freedom throughout other stages of transport. However, substrate interactions with structural hallmarks associated with known functional annotations can help reinforce selective preferences in molecular transport.
Antarctic Blue Ice Areas are hydrologically active, nutrient rich and contain microbially diverse cryoconite holes
Authors: Nowak Aga , Isaksson Elisabeth , Sunde Øyvind , Elvevold Synnøve , Sandven Håkon , Moholdt Geir , Hudson Stephen R. , Urset Anne , Edwards Arwyn , Rassner Sara M. E. , Pearce David , Hamre Børge , Hodson Andrew 
Published: June 2024

AbstractAntarctica is the coldest, windiest and least inhabited place on Earth. One of its most enigmatic regions is scoured by katabatic winds blue ice that covers 235,000 km2of the Antarctic fringe. Here, we demonstrate that contrary to common belief, high-altitude inland blue ice areas are not dry, nor barren. Instead, they promote sub-surface melting that enables them to become “powerplants” for water, nutrients, carbon and major ions production. Mapping cryoconite holes at an unprecedented scale of 62 km2also revealed a regionally significant resource of dissolved nitrogen, phosphorus (420 kg km−2), dissolved carbon (1323 kg km−2), and major ions (6672 kg km−2). We discovered that unlike on glaciers, creation of cryoconite holes and their chemical signature on the ice sheet is governed by ice movement and bedrock geology. Blue ice areas are near-surface hotspots of microbial life within cryoconite holes. Bacterial communities they support are unexpectedly diverse. We also show that near-surface aquifers can exist in blue ice outside cryoconite holes. Identifying blue ice areas as active ice sheet ecosystems will help us understand the role ice sheets play in Antarctic carbon cycle, development of near-surface drainage system, and will expand our perception of the limits of life.
Natural language processing analysis of the theories of people with multiple sclerosis about causes of their disease
Authors: Haag Christina , Steinemann Nina , Ajdacic-Gross Vladeta , Schlomberg Jonas Tom Thaddäus , Ineichen Benjamin Victor , Stanikić Mina , Dressel Holger , Daniore Paola , Roth Patrick , Ammann Sabin , Calabrese Pasquale , Kamm Christian Philipp , Kesselring Jürg , Kuhle Jens , Zecca Chiara , Puhan Milo Alan , von Wyl Viktor 
Published: June 2024

Abstract
Background
While potential risk factors for multiple sclerosis (MS) have been extensively researched, it remains unclear how persons with MS theorize about their MS. Such theories may affect mental health and treatment adherence. Using natural language processing techniques, we investigated large-scale text data about theories that persons with MS have about the causes of their disease. We examined the topics into which their theories could be grouped and the prevalence of each theory topic.

Methods
A total of 486 participants of the Swiss MS Registry longitudinal citizen science project provided text data on their theories about the etiology of MS. We used the transformer-based BERTopic Python library for topic modeling to identify underlying topics. We then conducted an in-depth characterization of the topics and assessed their prevalence.

Results
The topic modeling analysis identifies 19 distinct topics that participants theorize as causal for their MS. The topics most frequently cited are Mental Distress (31.5%), Stress (Exhaustion, Work) (29.8%), Heredity/Familial Aggregation (27.4%), and Diet, Obesity (16.0%). The 19 theory topics can be grouped into four high-level categories: physical health (mentioned by 56.2% of all participants), mental health (mentioned by 53.7%), risk factors established in the scientific literature (genetics, Epstein-Barr virus, smoking, vitamin D deficiency/low sunlight exposure; mentioned by 47.7%), and fate/coincidence (mentioned by 3.1%). Our study highlights the importance of mental health issues for theories participants have about the causes of their MS.

Conclusions
Our findings emphasize the importance of communication between healthcare professionals and persons with MS about the pathogenesis of MS, the scientific evidence base and mental health.
Internal State Terms in the Narratives of Bilingual Children With Developmental Language Disorder: The Role of Microstructure and Macrostructure
Authors: Altman Carmit , Fichman Sveta , Perry Noy , Osher Pola , Walters Joel 
Published: June 2024

Purpose:
We examined the role of narrative microstructure (production of words and sentences) and narrative macrostructure (organization of events) in the use of internal state terms (ISTs) in narratives of bilingual children with developmental language disorder (DLD) in their school language (SL).

Method:

Fifty-eight Russian–Hebrew bilingual preschool children aged 55–78 months divided into two groups participated: 16 bilingual children diagnosed with bilingual DLD and 42 with typical language development (TLD). Narratives were elicited in SL/Hebrew using the wordless picture book,
Frog, Where Are You?
Narratives were transcribed and coded for frequency of ISTs and classified as perceptual, linguistic, motivational, linguistic, emotional, or physical. ISTs were also examined in terms of their role in microstructure (tokens and types) and macrostructure (Character, Setting, Initiating Event, Internal Response, Plan, Attempt, and Consequence) categories.

Results:
In terms of microstructure, bilingual children with DLD produced fewer word types and tokens in general and fewer perceptual ISTs than bilingual TLD peers. In terms of macrostructure, children with DLD used six out of the seven story grammar elements in their narratives less than bilinguals with TLD. For ISTs and macrostructure, bilinguals with DLD produced fewer linguistic ISTs in Attempts than their peers with TLD.

Conclusions:
Bilingual children with DLD have difficulties in producing ISTs, and this difficulty is shown to be related to both microstructure and macrostructure abilities. Suggestions for clinical intervention are offered to assist children with DLD in producing narratives that involve mental state language related to characters' feelings, intentions, and goals.
Challenging gender stereotypes: representations of gender through social interactions in English learning textbooks
Authors: Huang Pingping , Liu Xu 
Published: June 2024

AbstractThis study explores the representation of gender through the social interactions presented in four sets of English textbooks used in China. By examining the representation of both gender stereotypes and changing roles, the results reveal that although traditional stereotypes exist in Chinese secondary school-level English textbooks, women’s changing social roles are acknowledged in that they are now beginning to be shown engaging in non-traditional female jobs. However, in family scenarios, women are still depicted as taking sole responsibility for housekeeping duties without any participation from adult males, showing the incomplete transformation of gender roles. No male characters are shown participating in non-traditional jobs, which reinforces the idea of the masculine role being ‘superior’ to feminine or non-masculine roles. The continued presence of gender stereotypes shows textbook editors’ tacit agreement with the gender norms. Drawing on gender as a fluid concept and social interactions of gender, this study acknowledges the variety and diversity of inputs of gender roles through social interactions in the learning community and suggests that students can be given access to a more gender-progressive education by improving the quality of social interactions between genders in textbooks and presenting a more equal view on gender roles.
Impact of COVID-19 on jump occurrence in capital markets
Authors: Zhu Min , Wen Shan , Song Yuping 
Published: June 2024

AbstractIn this paper, we investigate the relationship between the indicators for COVID-19 monitoring and the dynamic of jumps across six major financial markets including China, France, Italy, Germany, the UK, and the US. First, this paper finds that jumps occurred more frequently in the index returns during the COVID-19 pandemic. Second, the empirical findings suggest that the anxiety stemming from potential future control measures, which were prompted by updates in COVID-19 briefings, plays a significant role in explaining the jumps in index returns within financial markets. The strategies of ‘zero tolerance for COVID-19’, ‘maximum healthcare capacity’, and ‘less tolerance for restriction’ were carried out by China, European countries, and the US respectively. These diverse approaches to managing COVID-19 have a significant and varied impact on the market’s sudden price movements.