bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model
Authors: Amor Melina , Diaz Malena , Bianco Valentina , Svecla Monika , Schwarz Birgit , Rainer Silvia , Pirchheim Anita , Schooltink Laszlo , Mukherjee Suravi , Grabner Gernot F. , Beretta Giangiacomo , Lamina Claudia , Norata Giuseppe Danilo , Hackl Hubert , Kratky Dagmar 
Published: August 2024

Abstract
Background
Activation of brown adipose tissue (BAT) has gained attention due to its ability to dissipate energy and counteract cardiometabolic diseases (CMDs).

Methods
This study investigated the consequences of cold exposure on the BAT and liver proteomes of an established CMD mouse model based on LDL receptor-deficient (LdlrKO) mice fed a high-fat, high-sucrose, high-cholesterol diet for 16 weeks. We analyzed energy metabolism in vivo and performed untargeted proteomics on BAT and liver of LdlrKO mice maintained at 22 °C or 5 °C for 7 days.

Results
We identified several dysregulated pathways, miRNAs, and transcription factors in BAT and liver of cold-exposed Ldlrko mice that have not been previously described in this context. Networks of regulatory interactions based on shared downstream targets and analysis of ligand-receptor pairs identified fibrinogen alpha chain (FGA) and fibronectin 1 (FN1) as potential crosstalk factors between BAT and liver in response to cold exposure. Importantly, genetic variations in the genes encoding FGA and FN1 have been associated with cardiometabolic-related phenotypes and traits in humans.

Discussion
This study describes the key factors, pathways, and regulatory networks involved in the crosstalk between BAT and the liver in a cold-exposed CMD mouse model. These findings may provide a basis for future studies aimed at testing whether molecular mediators, as well as regulatory and signaling mechanisms involved in tissue adaption upon cold exposure, could represent a target in cardiometabolic disorders.

Graphical abstract
Combined biological effects of CBCT and therapeutic X-ray dose on chromosomal aberrations of lymphocytes
Authors: Gáldi Ádám , Farkas Gyöngyi , Gazdag-Hegyesi Szilvia , Koszta Enikő , Ágoston Péter , Pesznyák Csilla , Major Tibor , Takácsi-Nagy Zoltán , Polgár Csaba , Jurányi Zsolt 
Published: August 2024

Abstract
Background and purpose
Cone beam computed tomography (CBCT) is routinely used in radiotherapy to localize target volume. The aim of our study was to determine the biological effects of CBCT dose compared to subsequent therapeutic dose by using in vitro chromosome dosimetry.

Materials and methods
Peripheral blood samples from five healthy volunteers were irradiated in two phantoms (water filled in-house made cylindrical, and Pure Image CTDI phantoms) with 6 MV FFF X-ray photons, the dose rate was 800 MU/min and the absorbed doses ranged from 0.5 to 8 Gy. Irradiation was performed with a 6 MV linear accelerator (LINAC) to generate a dose–response calibration curve. In the first part of the investigation, 1–5 CBCT imaging was used, in the second, only 2 Gy doses were delivered with a LINAC, and then, in the third part, a combination of CBCT and 2 Gy irradiation was performed mimicking online adapted radiotherapy treatment. Metaphases were prepared from lymphocyte cultures, using standard cytogenetic techniques, and chromosomal aberrations were evaluated. Estimate doses were calculated from chromosome aberrations using dose–response curves.

Results
Samples exposed to X-ray from CBCT imaging prior to treatment exhibited higher chromosomal aberrations and Estimate dose than the 2 Gy therapeutic (real) dose, and the magnitude of the increase depended on the number of CBCTs: 1–5 CBCT corresponded to 0.04–0.92 Gy, 1 CBCT + 2 Gy to 2.32 Gy, and 5 CBCTs + 2 Gy to 3.5 Gy.

Conclusion
The estimated dose based on chromosomal aberrations is 24.8% higher than the physical dose, for the combination of 3 CBCTs and the therapeutic 2 Gy dose, which should be taken into account when calculating the total therapeutic dose that could increase the risk of a second cancer. The clinical implications of the combined radiation effect may require further investigation.
Assessment of agricultural residue potential for electrification of off-grid communities in the Sawla-Tuna-Kalba District of Ghana
Authors: Awafo Edward A. , Akolgo Gilbert A. , Awaafo Augustine 
Published: August 2024

Abstract
Background
There is a close link between the lack of electricity access and poverty indicators such as illiteracy, high infant mortality, lack of access to health care and malnutrition among others. Most rural farming communities in Ghana lack access to electricity due to the high cost of extending the grid to these communities. This lack of access tends to worsen the gap between urban and rural inhabitants regarding access to education, healthcare and development.

Methods
This study assessed the technical and theoretical potential of agricultural residues in providing electricity to off-grid communities. The study used crop production figures of maize, cassava, millet and groundnut in the Soma and Goyiri farming communities in the Sawla-Tuna-Kalba District to conduct an assessment of the theoretical and technical potential of residues from the crops. The production figures of these crops were obtained from the District Office of the Ministry of Food and Agriculture. Expected electricity demand of households, schools and health centers in the study communities were collected and employed for the projected load demand estimates.

Results
The study found that 312.23 MWh/day of electricity could be generated from the combined residues of maize, cassava, millet and groundnut from the two communities. This amount of electricity is capable of providing ~ 202 to 263 times the peak electricity demand of the studied communities. Out of the total electricity demand of the two communities, only about 91 kWh/day is needed for use in a school and Community Health Promotion and Services (CHPS) compound, implying that the electricity from crop residues can also help to improve education and health provision in the rural communities.

Conclusion
It is concluded that the potential of crop residues in meeting the electricity demand of off-grid communities is enormous. Hence, it must be considered in Ghana’s energy development plans to achieve universal electricity access.
Comparison of classical and patient-preferred music on anxiety and recovery after ınguinal hernia repair: a prospective randomized controlled study
Authors: Akelma Fatma Kavak , Altınsoy Savaş , Nalbant Burak , Özkan Derya , Ergil Jülide 
Published: August 2024

AbstractBackgroundWe aimed to evaluate the effects of preoperative listening to patient-preferred music and classical music on postoperative anxiety and recovery.MethodsA prospective, randomized controlled, single-blind study included 255 patients who were scheduled for elective inguinal hernia operation under general anesthesia. Spielberger state State-Trait Anxiety Inventory form 1,2 (STAI-I, STAI-II), Quality of Recovery Score-40 (QoR-40) were applied in the preoperatively. In the preoperative period, the preferential music group (group P) patients listened to their favorite music, while patients in the classical music group (group C) listened to classical music, music was not played in the control group (group N). STAI-I, QoR-40 questionnaire, pain status, and patient satisfaction in the postoperative period were recorded by a blinded investigator.ResultsA total of 217 patients participated in the study analysis. Postoperative STAI-1 score was lower in group P than in group N (p = 0.025) and was similar among other groups. The postoperative QoR-40 score was significantly higher in group P than in group N (p = 0.003), and it was similar between the other groups. While SBP, DBP and HR premusic and post-music changes were significant, there was no difference in other groups. There was no difference between the groups in the NRS score. The patient satisfaction score was significantly higher in group P.ConclusionsPreoperative patient-preferred music application reduces postoperative anxiety and improves recovery quality compared to classical music. In addition, regulation of hemodynamic data and patient satisfaction increase in a preferential music application, but pain scores do not change.Trial registrationNCT04277559|https://www.clinicaltrials.gov/
The moderating effect of altruism on the relationship between occupational stress and turnover intentions: a cross-sectional study of community rehabilitation workers in China
Authors: Liu Nian , Shu Yiyang , Lu Wei , Lin Yongshi 
Published: August 2024

Abstract
Background
In China, community rehabilitation workers are facing a growing challenge related to heavy occupational stress, which is having an impact on employment turnover. Previous studies have explored the effect of the public service motivation of workers in “helping” jobs on occupational stress or turnover intention, but there is a lack of clarification of the impact of altruism on turnover intention in the case of complex pathways involving various factors.

Methods
A stratified sampling method was used, and a total of 82 community rehabilitation workers who assist disabled people from 34 community health centres in Jiangmen city were included in the study from August to October 2022. The turnover intention, occupational stress, burnout, quality of life, altruism, and certain sociodemographic information of community rehabilitation workers were measured using a structured questionnaire. The partial least squares method was employed to construct and test the structural equation model.

Results
Although altruism had no direct impact on occupational stress or turnover intention, altruism moderated the effect of occupational stress on burnout (βMod = −0.208) and quality of life (βMod = 0.230) and weakened the mediation of burnout and quality of life between occupational stress and turnover intention.

Conclusions
This study proposes to address the dilemma of “strong function” and “weak specialty” in community rehabilitation services and to conduct positive psychological interventions for community rehabilitation workers through the guidance of altruistic values.
Travellers with prosthetic limbs, a neglected population. A perspective on what travel health practitioners need to know
Authors: Bauer Irmgard L. , Nagaraja Vikranth H. 
Published: August 2024

Abstract
Background
The benefits of travel for the wellbeing of people of all ages and abilities are well known, though travellers with prostheses have so far been excluded. Limb loss, due to trauma, vascular disease, cancer, or infections requires a prosthesis for cosmesis and functionality. The life-changing event of losing a limb and the considerable psychological adjustment to accept an altered body image influence rehabilitation and self-management as well as the participation in social activities, such as sport and travel. The challenge of travel lies not only in transferring practical impediments encountered at home to another location; familiar coping strategies may require unexpected adjustments. After presenting background information on limb loss and prostheses, the purpose of this paper was to review literature on health advice for travellers with prosthetic limbs.

Method
All major data bases were searched for peer-reviewed literature using a variation of keyword combinations around travel and prosthetics. Relevant journals were searched individually, and selected authors and university departments contacted. No evidence-based results were obtained. The search then moved to grey literature including documents from relevant organisations, professional bodies, government websites, manufacturers, airlines, prosthetic/physiotherapy clinics, sport organisations to approaching amputees, including veterans and athletes, directly.

Result
The list of collated travel advice for people with artificial limbs relates to (1) trip preparation, (2) packing (especially considering the mechanical and/or electrical requirements of the prosthesis), (3) travelling by plane as the most covered mode of travel, and (4) navigating airports and airport security, which may be used by travel health practitioners while awaiting evidence-based guidelines.

Conclusion
This is the first paper on travel with a prosthetic limb in any field, including travel medicine. Therefore, travel health practitioners have no evidence-based guidelines at their disposal required for high-quality care for this neglected population. Preliminary recommendations for clinical practice, advice for required updates in education, and suggestions for urgently needed research are provided to replace current hints and tips with evidence so that travellers with prostheses are no longer ‘out on a limb’.
Person-centred quality indicators for Australian aged care assessment services: a mixed methods study
Authors: Smith Sandra , Travers Catherine , Martin-Khan Melinda , Webb Ivy , Miller Elizabeth , Thompson Jane , Roberts Natasha 
Published: August 2024

Abstract
Background
Aged Care Assessment Teams are the assessment component of the Australian aged care system. Their purpose is to undertake needs-based assessments to determine an older person’s eligibility for, and access to Commonwealth-funded aged care services. There are no measures that tell us if the aged care assessment service is of high quality from the perspective of the person being assessed. Quality measures have been developed and introduced in Australian residential aged care facilities. These however, have not considered the perspectives of those living in this setting. Quality measures for home care services have also been recommended.
This research aims to address the gap in person-centred quality measures by asking current and future service users of aged care assessment services to vote on the importance of 24 person-centred quality indicators (PC-QIs), that were developed in a previous study using a modified Delphi method approach supported by engagement with a consumer led Advisory Board.

Methods
This mixed methods study used the RAND/UCLA Appropriateness Method to reach consensus on a final set of PC-QIs. Twenty-five community-dwelling older people in Brisbane, Australia, voted on the importance of 24 PC-QIs using a five-point Likert scale. A consensus statement for PC-QI elimination was determined prior to participants voting. Voting was undertaken with participants individually either face-to-face or via telephone, in their homes. To capture any narrative provided by participants regarding each PC-QI, participant voting sessions were audio-recorded and subsequently transcribed verbatim.
Quantitative data from participant votes for each PC-QI were calculated and statistically described by median, interquartile range, consensus met, percentile, percentile rank, rank order, median and standard deviation. PC-QIs were then assessed against the consensus statement for elimination and rank ordered according to importance to participants. Content analysis of qualitative data from audio transcriptions was conducted to determine the presence of certain words supporting participant votes for each PC-QI.

Results
No PC-QIs were eliminated during voting. Variation existed among participants’ ratings of importance for each PC-QI. Final quality domains, their respective title, quality indicator descriptor and supporting qualitative data are presented. Five PC-QIs had a median of five, no votes recorded below four, an interquartile range of zero, and a rank order score of one, two and four, out of a possible ten, indicating they were of highest importance to participants.

Conclusion
Participants reached consensus on 24 evidence-based PC-QIs that represent measures of quality of aged care assessment services from the perspectives of current and future service users.
One health: a structured review and commentary on trends and themes
Authors: Brown Helen Louise , Pursley Isabella Grace , Horton Daniel L. , La Ragione Roberto M. 
Published: August 2024

AbstractBackgroundOne Health (OH) is defined as a unifying approach aiming to sustainably balance and optimise the health of people, animals and the ecosystem. It recognises that the health of humans, animals (both domestic and wild), plants and the wider ecosystem are both interdependent and linked. As a concept, it aims to address complex problems requiring input from multiple disciplines. Suitable issues for OH approaches typically include global issues which can widely impact not only the health of humans and animals, but also have a significant environmental impact. Examples include emerging zoonotic diseases and antimicrobial resistance (AMR). Interpretations and use of the term OH differ in the literature and have the potential to dilute its impact. The meaning of OH among the research community has evolved over time. Here, we collate the OH relevant literature from the last two decades, identifying major themes and trends and considering how OH has been embraced differently across various geographical regions.Methods and resultsBibliographic databases were searched using the term “One Health” AND (“Veterinary” OR “Animal”) AND (“Medicine” OR “Human”) AND (“Environment” OR “Ecosystem”) during the period between 1980 and 2022. Data analysis and narrative synthesis identified themes, similarities, and differences within literature. Web of Science and PubMed returned 948 and 1250 results for the period mentioned above. The predominant literature focused on human health, with veterinary health second, although often to benefit human health. It was found that OH is often utilised as a public health approach, generally towards the end of disease surveillance and control. Interestingly, while authors from low- and middle-income countries were well-represented within studies using the term OH, they were less well-represented as corresponding authors.ConclusionsThe predominant focus of the literature was on human and veterinary health, implying OH approach is human-orientated, despite its suggestion that all domains share a common ‘health’. Potential improvement to OH could be achieved through greater incorporation of the environmental and social sciences for a more encompassing approach.
Effect of physiotherapy intervention (chest physiotherapy) on chronic obstructive pulmonary disease (COPD) in a 72-year-old patient: a case report
Authors: Womboh Idoo , Bappah Babangida Shehu , Ewah Patrick Ayi , Ali Hafsat Maina , Awotidebe Adedapo Wasiu 
Published: August 2024

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is a progressive obstruction of the airflow that is often fatal if not appropriately managed. COPD is prevalent among older adults worldwide, and diagnosis is often missed in comprehensive geriatric assessment. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, the management approach includes pharmacological, non-pharmacological treatment, and surgery in severe cases. This case report determines the effect of physiotherapy intervention (a non-pharmacological approach) on geriatric patients with COPD.

Case presentation
This is a case report of a 72-year-old male patient who presented as an outpatient with COPD grade D (GOLD guidelines) with a forced expiratory volume in 1 s (FEV1) value of 52%. The patient had 3 acute episodes of exacerbation but was stabilized. The first episode of shortness of breath was 2 years ago while taking a brisk walk at home. He was immediately rushed to the hospital where he was placed on hospital admission and managed for about 2 weeks and was discharged but to continue physiotherapy on an outpatient basis due to the proximity of his home from the hospital. On physical examination with chronic obstructive pulmonary assessment test (CAT), 6-min walk test (6MWT), and functional assessment with the Barthel Index, the patient was easily fatigued and had challenges in performing basic activities of daily living (BADL). The patient had 72 sessions of physiotherapy interventions for 6 months which consisted of education, purse-lip breathing, active cycle of breathing technique, incentive spirometry exercise, aerobic exercise, and home exercise aimed at improving activity tolerance, encouraging diaphragmatic breathing, enhancing sputum clearance, improving function, and overall quality of life.
Improvement was initially gradual and then significant in about the third month of the intervention. Activity tolerance improved with a 6MWT of 2 laps. The patient developed more confidence in performing ADL and leaving his home despite his lung condition as seen in CAT scores.

Conclusions
Overall, results from this study showed that COPD is a treatable condition that is amenable to physiotherapy interventions in a multidisciplinary approach.
Heterostructure channel designs for the topological interface state of surface water waves using topology optimization
Authors: Liu Ting , Liu Hongwei , Yin Jingwei 
Published: August 2024

Abstract
The increase of the concentrated density of wave energy is conducive to improving the generation efficiency of wave power generation. Interface states induced in the heterostructure channels can be applied to concentrate the surface water wave. The optimal designs of heterostructure channels can be found through the topology optimization based on the multiple population genetic algorithm to induce a topological interface state with high transmission at the desired frequency. The introduction of the topological interface state effectively and steadily increases the wave energy density in a certain space and improves the robustness and the localization of the water wave concentrator. This topology optimization method provides a design scheme for the wave energy concentrator in the field of ocean engineering.
Hypercalcemia in Pregnancy Caused by a Uterine Myoma
Authors: van der Leij Stephanie , Hertog Doenja 
Published: August 2024

Abstract
We present a case of a PTH-related peptide (PTH-rp) producing uterine myoma, leading to hypercalcemia in pregnancy. Our patient presented with dehydration, hypotension, delirium, and malnutrition. Due to a serum calcium level of 17.9 mg/dL (4.48 mmol/L) (reference range 8.8-11.2 mg/dL; 2.20-2.80 mmol/L), prompt treatment with hydration and calcitonin was initiated. The patient went into labor before we could consider other treatment options. Although uncommon in pregnancy, it is of great importance to identify hypercalcemia since it is related to a high risk of maternal and neonatal morbidity and mortality. Because bisphosphonates are contraindicated in pregnancy, hydration and calcitonin are the cornerstones of treatment for PTH-rp-induced hypercalcemia.
The Marginal Value of Cash: Structural Estimates from a Model with Financing and Agency Frictions
Authors: Dasgupta Sudipto , Li Di , Li Erica X. N. 
Published: August 2024

How much value does an additional dollar of cash create for a firm? It is generally recognized that the marginal value of cash (MVC) can either exceed or fall below one dollar. Estimates of MVC can guide corporate cash and payout policy, indicate the quality of governance, and make a firm a target for takeover or activism. Yet the existing methods of estimation lack a rigorous theoretical foundation and often provide implausibly high or low estimates. In this paper, we provide a formulation of MVC and structurally estimate the MVC based on a model that encompasses the important determinants for the choice of cash savings, including financing and agency costs. We find that firms with large cash and capital stocks have lower marginal value of cash, whereas the relationship between leverage and marginal value of cash is hump shaped. Two quasi-natural experiments validate the MVC estimates. This paper was accepted by Lukas Schmid, finance. Funding: D. Li would like to thank the support by the Guangdong Natural Science Foundation [Grant 2024A1515011703]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01013 .