bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of Helicobacter pylori eradication for precancerous lesions of the gastric remnant
Authors: Sakakibara Masatoshi , Ando Takafumi , Ishiguro Kazuhiro , Maeda Osamu , Watanabe Osamu , Hirayama Yutaka , Morise Kazuhiro , Maeda Keiko , Matsushita Masanobu , Furukawa Kazuhiro , Funasaka Kohei , Nakamura Masanao , Miyahara Ryoji , Goto Hidemi 
Published: December 2014

AbstractBackground and AimSecondary stomach cancer in lesions of the remnant stomach occurs relatively soon after distal gastrectomy using the Billroth I reconstruction procedure. Prophylactic eradication of Helicobacter pylori after endoscopic resection of early gastric cancer should be used to prevent the development of metachronous gastric carcinoma. However, the effect of H. pylori eradication on the gastric remnant has not been clearly determined.MethodsEight patients who were H. pylori‐positive after distal gastrectomy for primary gastric cancer underwent eradication therapy and were followed by endoscopy for 9 years. Upper gastroenteroscopy series were done before and at 1, 3, 5, 7 and 9 years after eradication, and biopsy specimens were taken from the lesser and greater curvatures, respectively. Histological changes, including chronic inflammation, activity, atrophy, and intestinal metaplasia, were evaluated using the updated Sydney system.ResultsSuccessful eradication was confirmed using the urea breath test in all eight patients. Chronic inflammation scores were improved after eradication at both the lesser (mean scores ± SD: before eradication, 2.9 ± 0.5; 1 year after, 2.3 ± 0.4; 3 years, 1.8 ± 0.3; 5 years, 1.5 ± 0.3; 7 years, 1.3 ± 0.3; and 9 years, 1.0 ± 0.3) and greater curvatures (before, 2.9 ± 0.4; 1 year after, 1.9 ± 0.3; 3 years, 1.4 ± 0.4; 5 years, 1.3 ± 0.3; 7 years, 1.1 ± 0.2; and 9 years, 0.6 ± 0.3). Atrophy scores improved more quickly after eradication than chronic inflammation scores at both the lesser (before, 2.4 ± 0.5; 1 year after, 1.8 ± 0.4; 3 years, 0.8 ± 0.3; 5 years, 0.3 ± 0.1; 7 years, 0.0; and 9 years, 0.0) and greater curvatures (before, 2.2 ± 0.4; 1 year after, 1.3 ± 0.3; 3 years, 0.5 ± 0.3; 5 years, 0.0; 7 years, 0.0; and 9 years, 0.0). No secondary stomach cancers were found on endoscopy.ConclusionsUndergoing H. pylori eradication improved possible precancerous lesions of the gastric remnant among patients who had undergone distal gastrectomy. Prophylactic H. pylori eradication in the gastric remnant may be useful in preventing the development of metachronous gastric carcinoma.
Decrease of serum level of gastrin in healthy Japanese adults by the change of Helicobacter pylori infection
Authors: Shimoyama Tadashi , Chinda Daisuke , Matsuzaka Masashi , Takahashi Ippei , Nakaji Shigeyuki , Fukuda Shinsaku 
Published: December 2014

AbstractBackground and AimIn Japan, the prevalence of Helicobacter pylori infection is decreasing and the number of patients who receive eradication therapy is increasing. Although the serum level of gastrin is affected by H. pylori infection, the normal level has been unchanged for more than 20 years. The aim of this study was to study whether the present normal range for the serum gastrin level is appropriate for Japanese at present or in the near future.MethodsWe studied 810 adults (40–80 years old) who participated in a health survey in 2012. We measured H. pylori stool antigen, titer of serum antibody to H. pylori, and serum level of gastrin. The patient's H. pylori status was defined as positive or negative when the results of both stool antigen and serology were concordant. Subjects who were taking proton‐pump inhibitor and had a previous history of gastric surgery were excluded.ResultsMean serum level of gastrin was 66.2 ± 49.6 pg/mL in 281 H. pylori‐negative subjects and 69.7 ± 42.2 pg/mL in 115 patients who had H. pylori eradicated at least 2 years ago. The level of gastrin was 134.4 ± 145.6 pg/mL in 224 patients with H. pylori infection and the level was significantly higher when compared with those in uninfected subjects and eradicated patients (P < 0.01).ConclusionsBecause the situation of H. pylori infection has changed remarkably in Japan, a new appropriate normal range of gastrin should be established using current Japanese populations.
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats
Authors: Takeuchi Koji , Takayama Shinichi , Hashimoto Erika , Itayama Misaki , Amagase Kikuko , Izuhara Chitose 
Published: December 2014

AbstractBackground and AimWe examined the prophylactic effect of rebamipide on gastric bleeding induced by the perfusion of aspirin (acetylsalicylic acid [ASA]) plus clopidogrel under the stimulation of acid secretion in rats.MethodsUnder urethane anesthesia, acid secretion was stimulated by the i.v. infusion of histamine (8 mg/kg/h), and the stomach was perfused with 25 mmol/L ASA at a rate of 0.4 mL/min. Gastric bleeding was evaluated as the concentration of hemoglobin in the perfusate. Clopidogrel (30 mg/kg) was given p.o. 24 h before the perfusion. Rebamipide (3–30 mg/kg) or other antiulcer drugs were given i.d. before the ASA perfusion.ResultsSlight gastric bleeding or damage was observed with the perfusion of ASA under the stimulation of acid secretion, whereas these responses were significantly increased in the presence of clopidogrel. Both omeprazole and famotidine inhibited acid secretion and prevented these responses to ASA plus clopidogrel. Rebamipide had no effect on acid secretion, but dose‐dependently prevented gastric bleeding in response to ASA plus clopidogrel, with the degree of inhibition being almost equivalent to that of the antisecretory drugs, and the same effects were obtained with the gastroprotective drugs, irsogladine and teprenone. These agents also reduced the severity of gastric lesions, although the effects were less than those of the antisecretory drugs.ConclusionsThese results suggest that the antiplatelet drug, clopidogrel, increases gastric bleeding induced by ASA under the stimulation of acid secretion, and the gastroprotective drug, rebamipide, is effective in preventing the gastric bleeding induced under such conditions, similar to antisecretory drugs.
Acetic acid induces cell death: An in vitro study using normal rat gastric mucosal cell line and rat and human gastric cancer and mesothelioma cell lines
Authors: Okabe Susumu , Okamoto Toshihiro , Zhao Chun‐Mei , Chen Duan , Matsui Hirofumi 
Published: December 2014

AbstractBackground and AimWe recently reported that topical application of acetic acid promptly caused tumor necrosis in a mouse model of gastric cancer. The aim of the present study was to examine whether acetic acid can directly induce cancer cell death.MethodsRat gastric epithelial cell line (RGM‐1), rat gastric carcinoma cell line (RGK‐1), human gastric cancer cell line (KATO III), and human mesothelioma cell lines (ACC‐MESO1 and MSTO‐211H) were used. Acetic acid was added into the cell culture at different concentrations for different time periods. Cell death was analyzed by MTT assay, flow cytometry, and trypan blue exclusion test.ResultsAcetic acid promptly induced the cell death of RGM‐1, RGK‐1 cells, and KATO III cells in a concentration‐dependent manner from 0.01% to 0.5%. Acetic acid at 0.5% for 1 min induced the cell death by 80%. RGK‐1 cells were more sensitive to acetic acid than RGM‐l cells. KATO III cells were more sensitive to acetic acid than RGK‐1 cells. Acetic acid at 0.5% for 10 min induced almost complete cell death of ACC‐MESO1 and MSTO‐211H.ConclusionsAcetic acid is a powerful anticancer agent. Topical application of acetic acid may be a feasible approach for the treatments of gastric cancer and possibly other malignancies.
Prevalence of Helicobacter pylori infection with healthy subjects in Japan
Authors: Hirayama Yoji , Kawai Takashi , Otaki Junji , Kawakami Kohei , Harada Yoshimi 
Published: December 2014

AbstractBackground and AimOnly few large‐scale epidemiological studies have examined the prevalence of Helicobacter pylori (H. pylori) infection in Japan. The aim of the present study was to estimate the prevalence and incidence of H. pylori infection in Japan in terms of gender, age and region.MethodsSerum anti‐H. pylori antibody testing was included in workers' annual health checks conducted by T‐company's health insurance association in 2008. The testing was continued for the next 5 years in 35‐year‐old subjects.ResultsThe total number of subjects was 21 144 (18 398 males and 2746 females). Stratified for age, there were 5016 subjects (male : female = 4219:797) in their 30s, 8748 (7770:978) in their 40s, 5589 (4807:782) in their 50s, and 1769 (1584:185) in their 60s. The H. pylori seropositive rate (male : female) was 27.5% (27.5:27.7) overall, 18.0% (18.3:16.1) in subjects in their 30s, 22.9% (22.7:24.7) in those in their 40s, 37.4% (37.2:38.2) in those in their 50s, and 46.1% (45.7:49.2) in those in their 60s. The prevalence of H. pylori seropositivity increased as age increased; however, no significant differences were seen between genders or among regions (χ2 test).The numbers of 35‐year‐old subjects from 2008 to 2012 were 1072, 1107, 941, 1065, and 940, respectively. The corresponding H. pylori seropositive rates were 17.4, 17.4, 14.3, 13.3, and 14.0%, respectively.ConclusionThe Japanese H. pylori infection rate had already declined to 27.5% in 2008, with subjects in the 35–70 age range. The prevalence of H. pylori infection is also decreasing gradually from 2008 to 2012.
Evaluation of gastric cancer diagnosis using new ultrathin transnasal endoscopy with narrow‐band imaging: Preliminary study
Authors: Kawai Takashi , Yanagizawa Kyosuke , Naito Sakiko , Sugimoto Hiroko , Fukuzawa Masakatsu , Gotoda Takuji , Matsubayashi Jun , Nagao Toshitaka , Hoshino Sumito , Tsuchida Akihiko , Moriyasu Fuminori 
Published: December 2014

AbstractBackground and AimThe new developed ultrathin transnasal endoscope, the GIF‐XP290N, makes possible a resolving power similar to the GIF‐H260 at a distance of 3 mm. In this study, using the GIF‐XP290N, we evaluated whether endoscopic diagnosis (discrimination between benign and malignant) of gastric lesions is possible using nonmagnified narrow‐band imaging (NBI) endoscopy.MethodsThe subjects were 255 consecutive patients who underwent screening of the gastrointestinal tract using new ultrathin transnasal endoscopy. Their average age was 65.2 ± 11.4 years. The male‐female ratio was 2.5:1. All cases were examined using conventional white‐light imaging (WLI) and nonmagnified NBI. When a depressed lesion was detected in the stomach, it was examined using WLI, then NBI close examination (at about 3 mm). We observed the mucosal structure of the lesion using close visualization with NBI. Concerning mucosal structural changes, we looked for a clear demarcation line between the lesion and the surrounding mucosa, and loss, irregularity, or nonuniformity of the lesion mucosal microsurface pattern.ResultsA total of 52 depressed lesions were examined. The histological diagnosis was cancer for 8 lesions, and noncancer for 44 lesions. WLI examination yielded a sensitivity of 50.0% (4/8), specificity of 63.6% (28/44), and accuracy 61.5% (32/52). On the other hand, NBI close examination yielded a sensitivity of 87.5% (7/8), specificity of 93.2% (41/44), and accuracy of 92.3% (48/52), significantly higher.ConclusionNBI close examination using ultrathin transnasal endoscopy enables mucosal diagnosis even without magnification and was considered to be an effective technique for improving endoscopic diagnosis.
THE EFFECT OF BASEMENT FAULT REACTIVATION ON THE TRIASSIC – RECENT GEOLOGY OF KURDISTAN, NORTH IRAQ
Authors: Burberry C. M. 
Published: December 2014

The Zagros orogenic belt is underlain by a complex faulted Precambrian basement. Major fault trends originating in this basement have been invoked to explain large‐scale structural changes along the strike of the orogen, e.g. the development of the Kirkuk Embayment (Kurdistan, Iraq) and the Lurestan Salient (Iran). However, within the Kirkuk Embayment, these structural trends have not previously been considered as an interacting group of faults which are periodically reactivated. This contribution first presents a revised basement fault map for the Kirkuk Embayment, created from interpreted gravity data, existing fault maps and remote sensing lineament analyses. This map is then compared to surface structure maps, published facies maps and source rock maturity data using GIS techniques. The object is to define the relationship between the basement faults and surface structures, fades and source‐rock maturity through time.Surface anticline orientation and location, as well as a number of major facies changes within the cover sequence, and the maturity of Triassic source rocks, are constrained by the interaction of the Najd and Transverse fault trends. A third basement trend, the Nabitah trend, has a more subtle effect on Phanerozoic geology. The Kirkuk Embayment can be divided into a series of semi‐independent basement blocks, defined by these basement fault trends. The interaction of these semi‐independent blocks has created local but predictable differences in surface structures, sediment thickness and facies, and variations in the maturity of Triassic source units across the Kirkuk Embayment. An understanding of the location and behaviour of basement faults within this hydrocarbon province is therefore a valuable predictive tool in exploration.
Formation of a small impact structure discovered within the Agoudal meteorite strewn field, Morocco
Authors: Lorenz C. A. , Ivanova M. A. , Artemieva N. A. , Sadilenko D. A. , Chennaoui Aoudjehane H. , Roschina I. A. , Korochantsev A.V. , Humayun M. 
Published: December 2014

AbstractA relic impact structure was recognized within the strewn field of the Agoudal iron meteorite. The heavily eroded structure has preserved shatter cones in a limestone basement, and remnants of autochthonous and allochthonous breccias. Fragments of iron incorporated into the allochthonous breccia have a chemical composition (Ni = 5.16 wt%, Ir = 0.019 ppm) similar to that of the Agoudal meteorite, supporting a syngenetic origin of the strewn field and the impact structure. The total recovered mass of Agoudal meteorite fragments is estimated at approximately 500 kg. The estimated size of the SE–NW‐oriented strewn field is 6 × 2 km. Model calculations with minimal preatmospheric size show that a similar meteorite strewn field plus one small crater with observed shock effects could be formed by fragmentation of a meteoroid approximately 1.4 m in diameter with an impact angle of approximately 60° from the horizontal. However, the most probable is an impact of a larger, 3–4 m diameter meteoroid, resulting a strewn field with approximately 10 craters, 10–30 m in diameter each, plus numerous meteorite fragments. The calculated scattering area of meteorite shrapnel ejected from these impact craters could completely cover the observed strewn field of the Agoudal meteorite.
Disempowered, passive and isolated: how teenage mothers' postnatal inpatient experiences in the UK impact on the initiation and continuation of breastfeeding
Authors: Hunter Louise , Magill‐Cuerden Julia , McCourt Christine 
Published: December 2014

AbstractTeenage mothers in the UK and other developed English‐speaking nations are among those least likely to breastfeed. Evidence suggests more young mothers intend to breastfeed than actually start, indicating that their post‐birth experiences militate against initiating breastfeeding. We aimed to explore how the inpatient experiences of a group of young women who gave birth as teenagers influenced their feeding decisions and experiences, and ascertain their ideals for breastfeeding support. Six focus groups or interviews were conducted with 15 women aged 16–20 who had intended to breastfeed or breastfed. Women were recruited from teenage parent groups in Oxfordshire, UK. Ethical approval was obtained from the relevant authorities. Data were analysed inductively using a thematic approach. Three overriding themes of ‘postbirth experience on Labour Ward: disempowered and passive’; ‘the postnatal ward: alien, alone and exposed’; and ‘being there: a need for relational support’ were identified. Sub‐themes on Labour Ward were ‘feelings at birth: ‘so tired and so dazed’; ‘deliver, stitch, dress’; and ‘initiating feeding’. Participants described care that followed set routines, discouraging their initiating breastfeeding by compounding feelings of dependence and encouraging a passive role as midwives took control, often deciding when and how babies should be fed. Sub‐themes on the postnatal ward were ‘an alien environment’; ‘feeling exposed and judged’; and ‘miscommunications’. The young mothers' breastfeeding support requirements reflected those known to be desired by older women, but they particularly wanted guidance and esteem support to be provided by a health professional, while looking to their peers for emotional support.
Rare cause of absence of femoral arterial pulse: Bilateral common iliac artery hypoplasia
Authors: Tekgündüz Kadir Şerafettin , Ceviz Naci , Kantarcı Mecit , Demirelli Yaşar , Olgun Haşim , Caner İbrahim , Şahin İrfan Oğuz , Yolcu Canan 
Published: December 2014

AbstractCongenital anomaly of the iliac arteries is rare, and, given that patients are generally asymptomatic, diagnosis in the newborn period is difficult. Herein is presented the case of a newborn with bilateral hypoplasia of the common iliac arteries, seen on multi‐slice computed tomography while investigating the absence of femoral pulse. This anomaly is a rare cause of absence of femoral arterial pulse.
Successful treatment of relapsing autoimmune thrombotic thrombocytopenic purpura with rituximab
Authors: Sankararaman Senthilkumar , Jeroudi Majed , Ibrahim Hassan 
Published: December 2014

AbstractThrombotic thrombocytopenic purpura (TTP) is a rare but life‐threatening condition characterized by thrombotic microangiopathy. The standard treatment for TTP is plasmapheresis. For refractory or relapsing cases, various immunosuppressive agents have been tried, and among them rituximab has shown promising results. TTP is rarer in the pediatric age group and the use of rituximab in children with TTP is limited. Reported herein is the successful treatment of relapsing autoimmune TTP with rituximab in a 12‐year‐old girl.
Diffuse cerebral vasospasm with infarct after intrathecal cytarabine in childhood leukemia
Authors: Yoon Jong Hyung , Yoon Ju Young , Park Hyeon Jin , Son Meong Hi , Kim Su‐Hyun , Kim Woojun , Kim Ho Jin , Lee Sang Hyun , Park Byung‐Kiu 
Published: December 2014

AbstractAlthough the varied neurotoxicity of intrathecal (IT) chemotherapy for treatment of childhood acute leukemia is well known, most are related to transient post‐puncture headache, drug‐induced arachnoiditis, or leukoencephalopathy after methotrexate or cytarabine. Cerebral vasospasm leading to acute infarct after IT chemotherapy is very uncommon in children. Reported herein is a rare case of diffuse cerebral vasospasm with subsequent cerebral infarct after IT cytarabine in a 7‐year‐old boy with acute lymphoblastic leukemia, who successfully recovered with supportive management, and a review of the literature.
Cyclic fluctuation of blood pressure in neonatal neuroblastoma
Authors: Fujishiro Jun , Sugiyama Masahiko , Ishimaru Tetsuya , Uotani Chizue , Tsuchida Shinya , Takahashi Naoto , Shiozawa Ryosuke , Takita Junko , Iwanaka Tadashi 
Published: December 2014

AbstractHerein is described a case of neonatal neuroblastoma with cyclic blood pressure fluctuation and elevated catecholamines. The fluctuations stabilized after treatment with α‐adrenergic blocker and the perioperative course was uneventful. The possibility of catecholamine‐related symptoms including hypertension, heart failure, and blood pressure fluctuations should be considered in the treatment for neuroblastoma; if they are present, treatment with α‐blockers is effective.
Rare but threatening complication of otitis media: Lateral sinus thrombosis
Authors: Kafadar İhsan , Sözen Mukaddes Esra , Büyüktaş Aytaç Didem , Yalçın Koray 
Published: December 2014

AbstractAlthough appropriate use of antibiotics has decreased mortality, lateral sinus thrombosis is a rare, important intracranial complication of acute otitis media. Herein is described the case of a 5‐year‐old patient with lateral sinus thrombosis after acute otitis media. We emphasize the need to be alert for lateral sinus thrombosis when treating acute otitis media.
Antenatal ultrasound visualization of left testis that then vanished after birth
Authors: Ito Yasuo , Kitamura Hajime 
Published: December 2014

AbstractA 10‐month‐old infant was referred for disappearance of the left testis, which had been confirmed as present on antenatal ultrasound at 38 weeks of gestation, as well as at the newborn physical exam and the 4 month exam. The right testis was enlarged, whereas the left testis was palpated as a nubbin. The right testis measured on ultrasound was 1.6 × 0.8 × 1.0 cm; the testicular volume was 0.67 cm3. The left nubbin was hyperechoic, and accurate measurement of testicular components was difficult. At the age of 1 year 8 months, with the diagnosis of left vanishing testis, inguinal exploration was undertaken to rule out intra‐abdominal cryptorchidism. A fibrous nodule that connected to the spermatic vessels and the vas deferens was resected. Histopathology indicated a testicular remnant containing seminiferous tubules, hemosiderin deposits, calcification and marked fibrosis of the stroma, suggesting hemorrhagic infarction in utero.
Rare coincidence of familial central core disease and hemophagocytic lymphohistiocytosis
Authors: Lee Jin Sook , Lim Byung Chan , Kim Ki Joong , Hwang Yong Seung , Seong Moon‐Woo , Park Sung Sup , Park Sung‐Hye , Chae Jong‐Hee 
Published: December 2014

AbstractCentral core disease is a congenital myopathy caused by mutations in RYR1. A 6‐year‐old girl was admitted due to difficulty in running and climbing stairs. Another 13 members through the four generations had similar symptoms, indicating autosomal dominant inheritance. Muscle biopsy showed the characteristic central cores in predominant type 1 fibers. She later developed hemophagocytic lymphohistiocytosis. Mutation analysis identified c.14582G>A in RYR1, and c.1693delG and c.2954 + 5G>A in UNC13D. To our knowledge, this is the first case of a patient with central core disease, carrying a RYR1 mutation in a Korean large family, who had concurrent familial hemophagocytic lymphohistiocytosis.
Wheezing as a sign of cor triatriatum sinister culminating in multiple organ failure
Authors: Lee Meng‐Luen , Chen Ying‐Cheng , Lee Ming‐Sheng , Chien Jien‐Wen 
Published: December 2014

AbstractCardiac asthma or cardiac wheezing (CW) refers to a syndrome of dyspnea and wheezing that mimicks asthma clinically. Reported herein is the case of a 2‐month‐old boy who presented with refractory wheezing as a sign of cor triatriatum sinister (CTS) that culminated in overwhelming multiple organ failure in a short time. On the day of admission, oxygen saturation (SpO2) was <80%. Heart rate was 198 beats/min and respiratory rate 58 breaths/min. Chest radiogram showed pulmonary edema. Electrocardiogram showed right atrial enlargement and right ventricular hypertrophy. N‐terminal pro‐brain natriuretic peptide (NTproBNP) was very high at >20 000 pg/mL. Two‐dimensional echocardiography with Doppler showed CTS, which was complicated with severe pulmonary arterial hypertension due to flagrant pulmonary venous obstruction. Cardiac surgery was undertaken, after which pulmonary edema subsided, SpO2 increased to ≥96%, and NTproBNP dropped to normal. He was discharged 11 days later, and was free of cardiac, pulmonary, renal, and neurological sequelae at 24 month follow up.