bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Bulky, Spherical, and Fluorinated Anion BArF Induces ′On‐Water′ Activity of Silver Salt for the Hydration of Terminal Alkynes.
Authors: Saha Sayantani , Sarbajna Abir , Bera Jitendra K. 
Published: July 2014

AbstractThe conversion of 1,7‐octadiyne is high, but gives only a minor amount of 2,7‐octadione and mainly two different cyclized products.
ChemInform Abstract: Copper‐Catalyzed Reaction of Ketenimine and in situ Generated Immonium Ion: Access to α,β‐Unsaturated Amidines.
Authors: Yao Bangben , Shen Chuang , Liang Zunjun , Zhang Yuhong 
Published: July 2014

AbstractThe presented three component reaction provides a mild and efficient access to a wide variety of unsaturated amidines of which some might be useful for pharmacological application.
ChemInform Abstract: Spiroketal‐Based Diphosphine Ligands in Pd‐Catalyzed Asymmetric Allylic Amination of Morita—Baylis—Hillman Adducts: Exceptionally High Efficiency and New Mechanism.
Authors: Wang Xiaoming , Guo Peihua , Han Zhaobin , Wang Xubin , Wang Zheng , Ding Kuiling 
Published: July 2014

AbstractExceptionally high activity (with a TON up to 4750) of the palladium complexes of the SKP ligand is discovered for the title reaction.
ChemInform Abstract: Visible‐Light‐Mediated Decarboxylation/Oxidative Amidation of α‐Keto Acids with Amines under Mild Reaction Conditions Using O2.
Authors: Liu Jie , Liu Qiang , Yi Hong , Qin Chu , Bai Ruopeng , Qi Xiaotian , Lan Yu , Lei Aiwen 
Published: July 2014

AbstractThe first examples of a visible‐light‐mediated decarboxylation/oxidative amidation of α‐keto acid with aliphatic and aromatic primary amines are described.
ChemInform Abstract: Palladium(II) Complex of an Organotellurium Ligand as a Catalyst for Suzuki—Miyaura Coupling: Generation and Role of Nano‐Sized Pd3Te2.
Authors: Rao Gyandshwar Kumar , Kumar Arun , Singh Mahabir Pratap , Singh Ajai K. 
Published: July 2014

AbstractThe synthesis and properties of the precatalyst PDT are described, which acts via dispension of Pd3Te2 nanoparticles.
ChemInform Abstract: Synthesis and Characterization of New Pd(II) Non‐Symmetrical Pincer Complexes Derived from Thioether Functionalized Iminophosphoranes. Evaluation of Their Catalytic Activity in the Suzuki—Miyaura Couplings.
Authors: Ramirez‐Rave Sandra , Estudiante‐Negrete Fabiola , Toscano Ruben A. , Hernandez‐Ortega Simon , Morales‐Morales David , Grevy Jean‐Michel 
Published: July 2014

AbstractThe syntheses of PIN as well as an S‐Ph‐analogue are described and their structures are confirmed by X‐ray analysis.
ChemInform Abstract: Arylcalcium Halides as Substrates in Kumada‐Type Cross‐Coupling Reactions.
Authors: Langer Jens , Koehler Mathias , Goerls Helmar , Westerhausen Matthias 
Published: July 2014

AbstractNi‐catalyzed cross‐coupling reactions of arylcalcium iodides with aryl chlorides provide biphenyls in moderate yields.
ChemInform Abstract: Suzuki Coupling of Iodo and Bromoarenes Catalyzed by Chitosan‐Supported Pd‐Nanoparticles in Ionic Liquids.
Authors: Cotugno Pietro , Casiello Michele , Nacci Angelo , Mastrorilli Piero , Dell'Anna Maria Michela , Monopoli Antonio 
Published: July 2014

AbstractPalladium nanoparticles supported on chitosan are used in the Suzuki cross coupling of bromo and iodoarenes carried out in ionic liquids.
ChemInform Abstract: Air‐Stable Imidazole‐Imine Palladium Complexes for Suzuki—Miyaura Coupling: Toward an Efficient, Green Synthesis of Biaryl Compounds.
Authors: Ratniyom Jadsada , Chaiprasert Thanawat , Pramjit Songyos , Yotphan Sirilata , Sangtrirutnugul Preeyanuch , Srisuratsiri Pailin , Kongsaeree Palangpon , Kiatisevi Supavadee 
Published: July 2014

AbstractAn efficient, air‐stable protocol for the palladium‐catalyzed Suzuki—Miyaura cross coupling reaction is developed.
ChemInform Abstract: Ruthenium(II)‐Catalyzed Functionalization of C—H Bonds via a Six‐Membered Cyclometallate: Monoarylation of Aryl 2‐Pyridyl Ketones.
Authors: Li Bin , Darcel Christophe , Dixneuf Pierre H. 
Published: July 2014

AbstractIn most reactions small amounts of bisarylated byproducts are found which are readily removed by column chromatography.
ChemInform Abstract: Efficient Method for the Synthesis of α,α′‐Bis(arylmethylidene) Cycloalkanones Catalyzed by Bromodimethylsulfonium Bromide.
Authors: Zhao Cong‐Ying , Liu Ju‐Yan , Wang Ying , Zhao Xiao‐Jun , Yuan Bin , Yue Min‐Min 
Published: July 2014

AbstractThe title compounds (III) are simply obtained by crossed aldol condensation between aromatic aldehydes and ketones (I).
ChemInform Abstract: A Tandem Reaction of Benzyne with Functionalized Benzylidenephthalan to Afford Phenanthro[10,1‐bc]furan.
Authors: Siyang Hai Xiao , Wu Xu Rui , Liu Hui Ling , Wu Xin Yan , Liu Pei Nian 
Published: July 2014

AbstractThe title reaction provides highly concise and effective routes to related complex compounds including natural product derivatives.
ChemInform Abstract: Dehydrogenative Lactonization of Diols in Aqueous Media Catalyzed by a Water‐Soluble Iridium Complex Bearing a Functional Bipyridine Ligand.
Authors: Fujita Ken‐ichi , Ito Wataru , Yamaguchi Ryohei 
Published: July 2014

AbstractThe novel protocol allows the conversion of various benzylic and aliphatic diols into the corresponding lactones in aqueous media in the presence of a water soluble and reusable iridium catalyst.
ChemInform Abstract: Synthesis of Substituted Benzofurans by the Tandem One‐Pot Intramolecular Carbolithiation—Cyclization—Substitution Sequence.
Authors: Rodriguez Cristian , Nudelman Norma Sbarbati 
Published: July 2014

AbstractA variety of 3‐substituted‐2,3‐dihydrobenzofurans are conveniently obtained by tandem intramolecular carbolithiation‐cyclization of 2‐bromophenyl‐3‐phenylprop‐2‐enyl ether, followed by in situ trapping of the lithiated intermediate by suitable electrophiles.
ChemInform Abstract: Efficient Copper‐Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen‐Based Nucleophiles.
Authors: Lin Jin‐Shun , Xiong Ya‐Ping , Ma Can‐Liang , Zhao Li‐Jiao , Tan Bin , Liu Xin‐Yuan 
Published: July 2014

AbstractThe reaction is catalyzed by CuI and requires 25‐50 mol% of the catalyst for the N‐protected compounds and only 5‐10 mol% of CuI for the unprotected derivatives.
ChemInform Abstract: Preparation of Imidazolinium Salts by the Pd‐Catalyzed Reduction of Thioureas with Triethylsilane and Trialkylsilyl Triflate.
Authors: Matsumura Takehiko , Nakada Masahisa 
Published: July 2014

AbstractThe obtained imidazolium salts are precursors for NHCs.
ChemInform Abstract: One‐Pot Conversion of Carbon Dioxide, Ethylene Oxide, and Amines to 3‐Aryl‐2‐oxazolidinones Catalyzed with Binary Ionic Liquids.
Authors: Wang Binshen , Elageed Elnazeer H. M. , Zhang Dawei , Yang Sijuan , Wu Shi , Zhang Guirong , Gao Guohua 
Published: July 2014

AbstractAll yields determined by GC‐analysis.
ChemInform Abstract: One‐Pot, Catalyst‐Free Synthesis of Spirooxindole and 4H‐Pyran Derivatives
Authors: Ponpandian Thanasekaran , Muthusubramanian Shanmugam 
Published: July 2014

Abstractvia sequential Knoevenagel—Michael‐cyclization reactions of isatin or aromatic aldehydes, malononitrile, and 1,3‐dicarbonyl compounds
ChemInform Abstract: Highly Efficient Synthesis of 1,3‐Dioxanes via Prins Reaction in Broensted‐Acidic Imidazolium Ionic Liquid.
Authors: Kalkhambkar Rajesh G. , Jeong Yeon T. 
Published: July 2014

AbstractA wide range of 1,3‐dioxanes are obtained in a simple, convenient, cost‐effective, and environmentally friendly synthesis via reaction of a variety of aliphatic aldehydes with olefins.
ChemInform Abstract: Synthesis of Novel Benzo[6,7][1,4]oxazepino[4,5‐a]quinazolinone Derivatives via Transition‐Metal‐Free Intramolecular Hydroamination.
Authors: Mahdavi Mohammad , Foroughi Niloufar , Saeedi Mina , Karimi Maryam , Alinezhad Heshmatollah , Foroumadi Alireza , Shafiee Abbas , Akbarzadeh Tahmineh 
Published: July 2014

AbstractEfficient reaction conditions for the intramolecular hydroamination of dihydroquinazolinone derivatives to afford the title compounds (II) and (IV) in good yields are developed.
ChemInform Abstract: Catalytic, Asymmetric Synthesis of Phosphonic γ‐(Hydroxyalkyl)butenolides with Contiguous Quaternary and Tertiary Stereogenic Centers.
Authors: Frings Marcus , Thome Isabelle , Schiffers Ingo , Pan Fangfang , Bolm Carsten 
Published: July 2014

AbstractA highly regio‐ and stereoselective vinylogous Mukaiyama aldol reaction of α‐keto phosphonates and heterocyclic dienol silanes is developed.
ChemInform Abstract: Asymmetric Homoenolate Additions to Acyl Phosphonates Through Rational Design of a Tailored N‐Heterocyclic Carbene Catalyst.
Authors: Jang Ki Po , Hutson Gerri E. , Johnston Ryne C. , McCusker Elizabeth O. , Cheong Paul H.‐Y. , Scheidt Karl A. 
Published: July 2014

AbstractA highly selective NHC‐catalyzed synthesis of γ‐butyrolactones from the fusion of enals and α‐ketophosphonates is reported.
ChemInform Abstract: A Formal, One‐Pot β‐Chlorination of Primary Alcohols and Its Utilization in the Transformation of Terpene Feedstock and the Synthesis of a C2‐Symmetrical Terminal Bis‐Epoxide.
Authors: Swatschek Joerg , Grothues Lydia , Bauer Jonathan O. , Strohmann Carsten , Christmann Mathias 
Published: July 2014

AbstractThe presented stereoselective reaction sequence includes a copper mediated oxidation and an organocatalyzed α‐chlorination of terminal terpene alcohols.
ChemInform Abstract: Structure and Bioactivity of a Trisnorditerpenoid and a Diterpenoid from an Okinawan Soft Coral, Cespitularia sp.
Authors: Roy Prodip K. , Roy Michael C. , Taira Junsei , Ueda Katsuhiro 
Published: July 2014

AbstractCompounds (I) and (II) are evaluated for anti‐tumor and anti‐inflammatory activity.They show cytotoxicity against HCT116 cells (IC50 6.04 and 47 μM, respectively) and a dose dependent antiinflammatory effect in LPS/IFN‐γ‐stimulated inflammatory RAW 264.7 macrophage cells.
ChemInform Abstract: Inhibition of NO Production by Grindelia argentina and Isolation of Three New Cytotoxic Saponins.
Authors: Alza Natalia P. , Pferschy‐Wenzig Eva‐Maria , Ortmann Sabine , Kretschmer Nadine , Kunert Olaf , Rechberger Gerald N. , Bauer Rudolf , Murray Ana P. 
Published: July 2014

AbstractThree new oleane‐type saponins (I) named grindeliosides A‐C, are isolated from the ethanolic extracts of Grindelia argentina and evaluated for their inhibitory activities.
ChemInform Abstract: Stereoselective Total Synthesis of 4‐((3S,5R)‐3,5‐Dihydroxynonadecyl)phenol.
Authors: Yadav J. S. , Reddy P. Adi Narayana , Kumar A. Suman , Prasad A. R. , Reddy B. V. Subba , Al Ghamdi Ahmad Alkhazim 
Published: July 2014

AbstractThe stereoselective total synthesis of (I) is achieved via two alternative strategies involving either a Prins cyclization as the key step (28% overall yield) or a 1,3‐syn reduction of a β‐hydroxy ketone (30% overall yield).
ChemInform Abstract: Stereoselective Total Synthesis of (+)‐Boronolide, (+)‐Anamarine, 8‐epi‐Spicegerolide.
Authors: Subba Reddy B. V. , Veerabhadra Reddy V. , Praneeth K. 
Published: July 2014

AbstractThe synthesis starts from D‐xylose and comprises a highly diastereoselective Brown′s allylation and a ring closing metathesis reaction to build up the lactone moiety.
ChemInform Abstract: Hexaphenylethanes with an Ultralong C—C Bond: Expandability of the C—C Bond in Highly Strained Tetraarylpyracenes
Authors: Takeda Takashi , Uchimura Yasuto , Kawai Hidetoshi , Katoono Ryo , Fujiwara Kenshu , Suzuki Takanori 
Published: July 2014

AbstractReview: [29 refs.
ChemInform Abstract: Miniaturization of NMR Systems: Desktop Spectrometers, Microcoil Spectroscopy, and “NMR on a Chip” for Chemistry, Biochemistry, and Industry
Authors: Zalesskiy Sergey S. , Danieli Ernesto , Blumich Bernhard , Ananikov Valentine P. 
Published: July 2014

AbstractReview: 433 refs.
Macromolecule Loading into Spherical, Elliptical, Star‐Like and Cubic Calcium Carbonate Carriers
Authors: Parakhonskiy Bogdan V. , Yashchenok Alexey M. , Donatan Senem , Volodkin Dmitry V. , Tessarolo Francesco , Antolini Renzo , Möhwald Helmuth , Skirtach Andre G. 
Published: July 2014

AbstractWe fabricated calcium carbonate particles with spherical, elliptical, star‐like and cubical morphologies by varying relative salt concentrations and adding ethylene glycol as a solvent to slow down the rate of particle formation. The loading capacity of particles of different isotropic (spherical and cubical) and anisotropic (elliptical and star‐like) geometries is investigated, and the surface area of such carriers is analysed. Potential applications of such drug delivery carriers are highlighted.
An Innovative Approach for Highly Selective Direct Conversion of CO2 into Propanol using C2H4 and H2
Authors: Ahlers Stefan J. , Bentrup Ursula , Linke David , Kondratenko Evgenii V. 
Published: July 2014

AbstractMultifunctional catalysts are developed for converting CO2 with C2H4 and H2 into propanol. Au nanoparticles (NP) supported on TiO2 are found to facilitate this reaction. The activity and selectivity strongly depend on NP size, which can be tuned by the method of Au deposition and by promoting with K. The promoter improves the selectivity to propanol. Under optimized reaction conditions (2 MPa, 473 K, and CO2/H2/C2H4=1:1:1), CO2 is continuously converted into propanol with a near‐to‐100 % selectivity. Catalytic tests as well as mechanistic studies by in situ FTIR and temporal analysis of products with isotopic tracers allow the overall reaction scheme to be determined. Propanol is formed through a sequence of reactions starting with reverse water–gas shift to reduce CO2 to CO, which is further consumed in the hydroformylation of ethylene to propanal. The latter is finally hydrogenated to propanol, while propanol hydrogenation to propane is suppressed.
CD8+MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL‐18 serum levels in multiple sclerosis
Authors: Willing Anne , Leach Oliver A. , Ufer Friederike , Attfield Kathrine E. , Steinbach Karin , Kursawe Nina , Piedavent Melanie , Friese Manuel A. 
Published: July 2014

Recent findings indicate a pathogenic involvement of IL‐17‐producing CD8+ T cells in multiple sclerosis (MS). IL‐17 production has been attributed to a subset of CD8+ T cells that belong to the mucosal‐associated invariant T (MAIT) cell population. Here, we report a reduction of CD8+ MAIT cells in the blood of MS patients compared with healthy individuals, which significantly correlated with IL‐18 serum levels in MS patients. In vitro stimulation of peripheral blood mononuclear cells from healthy individuals and MS patients with IL‐18 specifically activated CD8+ MAIT cells. Moreover, IL‐18 together with T‐cell receptor stimulation induced, specifically on CD8+ MAIT cells, an upregulation of the integrin very late antigen‐4 that is essential for the infiltration of CD8+ T cells into the CNS. Notably, we were able to identify CD8+ MAIT cells in MS brain lesions by immunohistochemistry while they were almost absent in the cerebrospinal fluid (CSF). In summary, our findings indicate that an IL‐18–driven activation of CD8+ MAIT cells contributes to their CNS infiltration in MS, in turn leading to reduced CD8+ MAIT‐cell frequencies in the blood. Therefore, CD8+ MAIT cells seem to play a role in the innate arm of immunopathology in MS.
Basic Molten Salt Route to Prepare Porous SrTiO3 Nanocrystals for Efficient Photocatalytic Hydrogen Production
Authors: Liu Hui , Chen Xianliu , Yan Shicheng , Li Zhaosheng , Zou Zhigang 
Published: July 2014

AbstractSrTiO3 nanocrystals with porous structures were synthesized by a basic molten salt method. TEM images confirmed that the SrTiO3 nanocrystals possess a cellular morphology. High‐resolution TEM and selected‐area electron diffraction (SAED) analysis proved the existence of pores even in single crystals. Time‐dependent observations indicated that the formation of pores in the SrTiO3 nanocrystals resulted from the phase transformation of the TiO2 precursor in the basic solvent, and the process follows the dissolution–nucleation–aggregation growth mechanism. More importantly, the porous structure of the SrTiO3 nanocrystals is retained after the removal of the basic solvent by cool‐water washing, as the cool water can efficiently dissipate the heat of dissolution for the dissolution of the strong base into the water. The as‐prepared porous SrTiO3 nanocrystal photocatalysts exhibited a high rate of photocatalytic H2 evolution, which is attributed to their large specific surface area and good crystallinity.
Twin Polymerization: A Unique and Efficient Tool for Supporting Silver Nanoparticles on Highly Porous Carbon and Silica
Authors: Schliebe Christian , Gemming Thomas , Mertens Lutz , Mehring Michael , Lang Heinrich 
Published: July 2014

AbstractInvited for the cover of this issue is the group of Heinrich Lang at the University of Chemnitz, Germany. The cover image shows highly porous materials of type Ag@C (red) and Ag@SiO2 (blue), obtained by twin polymerization from the appropriate silver(I) carboxylate as silver source and 2,2'‐spirobi[4H‐1,3,2‐benzodioxasiline] as the specific twin monomer.
Matrix‐assisted laser desorption/ionization mass spectrometry and Raman spectroscopy: An interesting complementary approach for lipid detection in biological tissues
Authors: Jadoul Laure , Malherbe Cédric , Calligaris David , Longuespée Rémi , Gilbert Bernard , Eppe Gauthier , De Pauw Edwin 
Published: July 2014

Recently, matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has emerged as a powerful technique to study the distribution of lipids. However, quantification still remains a challenge because the MALDI signal is strongly affected by ion suppression effects. On the contrary, Raman spectroscopy is recognized as a non‐destructive analysis method and spectral images can also be acquired. The combination of these two techniques was applied for lipids detection in tissue sections. In MALDI, two lipids families (glycerophosphocholine, PC; gycerophosphoethanolamine, PE), three MALDI matrices (1,5‐diaminonapthalene, 1,5‐DAN; 2,5‐dihydroxybenzoic acid, 2,5‐DHB; α‐4‐hydroxicinammic acid, CHCA), and various mixtures of lipids were investigated. The nature of the lipid, as well as the nature of the matrix and the composition of the sample influences the signal of a given lipid. In Raman, despite a strong overlap with the spectrum of the native tissue, an intensity profile constructed along the diameter of the section clearly shows that the signature of one given lipid (a glycerophosphocholine) can be detected on a doped biological sample.Practical applications: This study highlights some important factors that should be considered in future lipids analyses by MALDI MSI and Raman spectroscopy. Ultimately, a combined approach of these two techniques will give information for instance about the alteration of the lipid metabolism associated with specific diseases.Detection of lipid in homogenate tissue section by matrix‐assisted laser desorption/ionization mass spectrometry and Raman spectroscopy.
NMR and Quantum‐Chemical Studies of Electrostatically Stabilized 1‐(N,N‐Substituted‐aminiomethyl)spirobi[3‐oxo(2,5‐dioxa‐1‐silacyclopentan)]ates (ES‐Silanates)
Authors: Lends Alons , Olszewska Ewa , Belyakov Sergey , Erchak Nikolai , Liepinsh Edvards 
Published: July 2014

ABSTRACT1‐(N,N‐substituted‐aminiomethyl)spirobi[3‐oxo(2,5‐dioxa‐1‐silacyclopentan)]ates were investigated using NMR, X‐ray, and quantum‐chemical methods. The free activation parameters for the inversion of “ammonium‐amine nitrogen” and the chirality change at the pentacoordinated silicon were determined by dynamic NMR spectroscopy. The latter proceeds via the dissociation of SiO bonds. The results were confirmed by quantum‐chemical calculations, the experimental observation of cross‐peaks in 2D‐EXSY NMR spectra, and the spirocycle exchange reactions. Transition pathways between the different diastereomers in solution were analyzed.
Multivariate analysis of the effect of operating conditions on hybridoma cell metabolism and glycosylation of produced antibody
Authors: Green Amy , Glassey Jarka 
Published: July 2014

AbstractBACKGROUNDChanges in glycosylation profiles of monoclonal antibodies can have significant impact upon the product quality. Control of critical process parameters in order to ensure consistent product quality is one of the core requirements of the FDA's QbD and PAT initiatives. The effect of operating conditions upon cell metabolism and the glycosylation profile of monoclonal antibody produced using hybridoma cell culture is investigated in this report.RESULTSPCA analysis of online process data and amino acid concentration profiles reflecting the cell metabolism indicates significant dependence on the operating conditions, particularly DO and pH. PLS models predicting product titre based on amino acid concentration and those predicting the glycosylation profile either based on product titre and glucose concentration or on amino acid concentrations show that both titre and glycosylation can be predicted with satisfactory accuracy for a range of operating conditions.CONCLUSIONSAccurate prediction of product titre and glycosylation profile based on amino acid concentration and process variables easily measured in real time opens up the opportunity to control the product quantity and quality during cultivation using critical process parameters, such as pH and DO. © 2014 Society of Chemical Industry
Magnetic graphene oxide as adsorbent for the determination of polycyclic aromatic hydrocarbon metabolites in human urine
Authors: Zhu Linli , Xu Hui 
Published: July 2014

Detection of monohydroxy polycyclic aromatic hydrocarbons metabolites in urine is an advisable and valid method to assess human environmental exposure to polycyclic aromatic hydrocarbons. In this work, novel Fe3O4/graphene oxide composites were prepared and their application in the magnetic solid‐phase extraction of monohydroxy polycyclic aromatic hydrocarbons in urine was investigated by coupling with liquid chromatography and mass spectrometry. In the hybrid material, superparamagnetic Fe3O4 nanoparticles provide fast separation to simplify the analytical process and graphene oxide provides a large functional surface for the adsorption. The prepared magnetic nanocomposites were characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, and vibrating sample magnetometry. The experimental conditions were optimized systematically. Under the optimal conditions, the recoveries of these compounds were in the range of 98.3–125.2%, the relative standard deviations ranged between 6.8 and 15.5%, and the limits of detection were in the range of 0.01–0.15 ng/mL. The simple, quick, and affordable method was successfully used in the analysis of human urinary monohydroxy polycyclic aromatic hydrocarbons in two different cities. The results indicated that the monohydroxy polycyclic aromatic hydrocarbons level in human urine can provide useful information for environmental exposure to polycyclic aromatic hydrocarbons.