bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the effect of auto-transplanted tooth for repairing maxillary sinus perforation compared to traditional flap repair
Authors: Liao Fenglin , Zhang Biao , Zhong Haoyan 
Published: August 2024

ABSTRACTObjectiveThe purpose of this study is to compare the outcomes of using auto-transplanted tooth and flap for repairing sinus perforation after tooth extraction. The aim is to provide a new reference for selecting appropriate repair methods for maxillary sinus perforation.Methods and materialsThis study involved 19 patients with sinus perforation who underwent treatment at the Department of Oral Surgery, Hospital of Stomatology Wuhan University, from March 2021 to September 2022. The study included two groups: a test group with 11 cases where perforation of the maxillary sinus mucosa greater than 5 mm was found during autologous tooth transplantation, and a control group with 8 cases where maxillary sinus mucosa perforation greater than 5 mm was found during tooth extraction. Clinical examination and radiographic examination were taken at 2 weeks, 1, 3, 6, and 12 months post-surgery of two groups. The two-year survival probability of the AT group was assessed using Kaplan-Meier survival analysis.ResultsThe success rate of the auto-transplantation (AT) group was 72.7% (8/11), while the success rate of the flap transfer (FT) group was 100%. Upon analysis, it was found that the survival probability of AT group was significantly lower when the gingival index(GI) score was 2 (51.8%), in comparison to when it was 0 or 1 (100%).ConclusionThe study findings demonstrated that the utilization of auto-transplanted teeth yielded a favorable outcome in restoring maxillary sinus perforation, suggesting its viability as a potential option.
Clinical, social, and economic impacts of colorectal cancer screening with the multi-target stool-DNA test: 10-year experience - a simulated study
Authors: Estes Chris , Dehghani Mohammad , Ozbay A. Burak , Vahdat Vahab , Limburg Paul J. , Brooks Durado 
Published: August 2024

ABSTRACTIntroductionIn the United States, colorectal cancer (CRC) remains a substantial public health challenge, with approximately 150,000 new cases diagnosed annually. Guidelines from organizations such as the United States Preventive Services Task Force (USPSTF) recommend several screening strategies, including endoscopic, radiologic, and stool-based options such as the multi-target stool DNA (mt-sDNA) test. In this analysis, we analyzed the estimated clinical, social, and economic impacts of mt-sDNA screening over the inaugural 10-year period for test availability.MethodsTo assess the effectiveness of CRC screenings with the mt-sDNA test, published rates of advanced precancerous lesions (APL) and cancer prevalence by stage, as well as the transition rate of APL to CRC for the average-risk population in the US were used for a simulated population. The mt-sDNA test’s sensitivity and specificity for APL and CRC were derived from previously published data. To assess the economic impact of screening with mt-sDNA compared to colonoscopy, we utilized data from literature regarding the time and resources required to prepare and complete each test. Furthermore, the costs of treatment according to the stage of colorectal cancer are considered, to show the value of CRC prevention and early detection.ResultsOur analysis indicates that mt-sDNA screening detected an estimated 98,000 cases of CRC and 525,000 individuals were found to have APLs, precursors to CRC. When using 10-year survival rate from CRC, it is estimated that the mt-sDNA test led to more than 34,000 patients surviving due to earlier intervention compared to no screening. Furthermore, the mt-sDNA test demonstrated approximately $22.3 billion cost savings compared to no screening, including an estimated $9.7 billion in cancer treatment costs through early CRC detection and an additional $12.6 billion resulting from cancer prevention through APL detection and management.ConclusionClinical availability, adoption, and growth of stool-based CRC screening have significantly increased overall screening rates in the US. It is estimated that mt-sDNA utilization will continue to grow, providing a home-based CRC screening solution for millions of screen-eligible US adults over the next decade and beyond.
Persistent changes in nociceptor translatomes govern hyperalgesic priming in mouse models
Authors: Sankaranarayanan Ishwarya , Kume Moeno , Mohammed Ayaan , Mwirigi Juliet M , Inturi Nikhil Nageswar , Munro Gordon , Petersen Kenneth A , Tavares-Ferreira Diana , Price Theodore J 
Published: August 2024

AbstractHyperalgesic priming is a model system that has been widely used to understand plasticity in painful stimulus-detecting sensory neurons, called nociceptors. A key feature of this model system is that following priming, stimuli that do not normally cause hyperalgesia now readily provoke this state. We hypothesized that hyperalgesic priming occurs due to reorganization of translation of mRNA in nociceptors. To test this hypothesis, we used paclitaxel treatment as the priming stimulus and translating ribosome affinity purification (TRAP) to measure persistent changes in mRNA translation in Nav1.8+ nociceptors. TRAP sequencing revealed 161 genes with persistently altered mRNA translation in the primed state. We identifiedGpr88as upregulated andMetrnas downregulated. We confirmed a functional role for these genes, wherein a GPR88 agonist causes pain only in primed mice and established hyperalgesic priming is reversed by Meteorin. Our work demonstrates that altered nociceptor translatomes are causative in producing hyperalgesic priming.
Incomplete lytic cycle of a widespreadBacteroidesbacteriophage leads to the formation of defective viral particles
Authors: Vendrell-Fernández Sol , Beamud Beatriz , Abou-Haydar Yasmina , Am de Sousa Jorge , Burlaud-Gaillard Julien , Kornobis Etienne , Raynal Bertrand , Vinh Joelle , Bikard David , Ghigo Jean-Marc 
Published: August 2024

AbstractAdvances in metagenomics have led to the identification of new intestinal temperate bacteriophages. However, their experimental characterization remains challenging due to a limited understanding of their lysogenic-lytic cycle and the common lack of plaque formationin vitro. In this study we investigated the hankyphage, a widespread transposable phage of prominentBacteroidessymbionts. Hankyphages spontaneously produced virions in laboratory conditions even in the absence of inducer, but virions did not show any evidence of infectivity. To increase virion production and raise the chances of observing infection events, we identified a master repressor of the hankyphage lytic cycle, RepCHP, whose silencing amplified hankyphage gene expression, enhanced replicative transposition and virion production. However, attempts to infect or lysogenize new host cells with different capsular types remained unsuccessful. Transmission electron microscopy and capsid DNA sequencing revealed an abnormal virion morphology and incomplete DNA packaging of the hankyphage, suggesting that it cannot complete its assembly in laboratory conditions for reasons that are yet to be identified. Still, metavirome and phylogenetic analyses were suggestive of hankyphage horizontal transmission. We could also detect the activity of diversity-generating retroelements (DGRs) that mutagenize the hankyphage minor tail fiber, and likely contribute to its broad host range. This study sheds light on the life cycle of this this abundant intestinal bacteriophage and highlights important gaps in our understanding of the factors required for the completion of its life cycle. Elucidating this puzzle will be critical to gain a better understanding of the hankyphage biology and ecological role.
Using integrated wildlife monitoring for quantifying the impact of emerging Bagaza virus in red-legged partridges in Portugal, 2012-2024
Authors: Queirós João , Costa João Basso , de Mello Gonçalo , Fontoura-Goncalves Catarina , Höfle Úrsula , Górtazar Christian , Alves Paulo Célio , Acevedo Pelayo , Goncalves David 
Published: August 2024

AbstractBagaza virus, a vector-borne flavivirus that causes significant mortality in wild bird species, emerged in Portugal in September 2021. This study used integrated wildlife monitoring to quantify its impact on a natural population of red-legged partridge (Alectoris rufa) in southern Portugal. We constructed a baseline model of population dynamics prior to the outbreak (2012-2021) and used this model to predict population size in subsequent years (2022-2024). This model, which included population abundance and demographic data of red-legged partridge, as well as climatic variables, showed a strong fit to the observed data, and the difference between the predicted and observed population size in 2022 suggests a Bagaza-induced mortality rate of at least 59% (95% CI 52-66%). In addition to enabling the adaptive management of populations, our results demonstrate that integrated wildlife monitoring offers epidemiological insights for risk assessment, highlighting its role in proactive wildlife disease surveillance within the One Health framework.
Enhancement strategies for the microbial protein production of nitrogen-fixing hydrogen-oxidizing bacterial community
Authors: Wang Haoran 
Published: August 2024

AbstractThe feasibility and superiority of utilizing nitrogen-fixing hydrogen-oxidizing bacteria (NF-HOB) for microbial protein (MP) production have been proposed. This study simulated air as the source of nitrogen and oxygen and enhanced production efficiency by employing key strategies, including continuous gas supply, selecting a higher hydrogen-to-oxygen ratio, designing initial community structures and domestication, and exploring appropriate hydraulic retention times (HRT) in continuous culture. The results demonstrated that sequencing batch culture achieved an MP titer of 0.98 g/L, with N2fixation efficiency surpassing natural nodules by two orders of magnitude at 1.6 mg N2per g dry biomass per hour. Under an HRT of 48 hours, MP volumetric productivity reached 2.297 mg/(L·h), accompanied by a maximum biomass yield of 0.11 g CDW/g COD-H2. The high abundance of nitrogenase may provide crucial functional support, enabling the NF-HOB community to exhibit potential beyond previous understanding.
Using phylogenetic summary statistics for epidemiological inference
Authors: Núñez Rafael C. , Hart Gregory R. , Famulare Michael , Lorton Christopher , Herbeck Joshua T. 
Published: August 2024

AbstractSince the coining of the term phylodynamics, the use of phylogenies to understand infectious disease dynamics has steadily increased. As methods for phylodynamics and genomic epidemiology have proliferated and grown more computationally expensive, the epidemiological information they extract has also evolved to better complement what can be learned through traditional epidemiological data. However, for genomic epidemiology to continue to grow, and for the accumulating number of pathogen genetic sequences to fulfill their potential widespread utility, the extraction of epidemiological information from phylogenies needs to be simpler and more efficient. Summary statistics provide a straightforward way of extracting information from a phylogenetic tree, but the relationship between these statistics and epidemiological quantities needs to be better understood. In this work we address this need via simulation. Using two different benchmark scenarios, we evaluate 74 tree summary statistics and their relationship to epidemiological quantities. In addition to evaluating the epidemiological information that can be inferred from each summary statistic, we also assess the computational cost of each statistic. This helps us optimize the selection of summary statistics for specific applications. Our study offers guidelines on essential considerations for designing or choosing summary statistics. The evaluated set of summary statistics, along with additional helpful functions for phylogenetic analysis, is accessible through an open-source Python library. Our research not only illuminates the main characteristics of many tree summary statistics but also provides valuable computational tools for real-world epidemiological analyses. These contributions aim to enhance our understanding of disease spread dynamics and advance the broader utilization of genomic epidemiology in public health efforts.Author SummaryOur study focuses on the use of phylogenetic analysis to get valuable epidemiological insights. We conducted a simulation study to evaluate 74 phylogenetic summary statistics and their relationship to epidemiological quantities, shedding light on the potential of each of these statistics to quantify different characteristics of disease spread dynamics. Additionally, we assessed the computational cost of each statistic. This gives us additional information when selecting a statistic for a particular application. Our research is available through an open-source Python library. This work helps us enhance our understanding of phylogenetic tree structures and contributes to the broader application of genomic epidemiology in public health initiatives.
Effect and acceptability of co-created interventions linking public rehabilitation programs with civil society involvement for physical activity engagement – a convergent mixed methods pilot study
Authors: Thorsen Ida Kær , Midtgaard Julie , Hansen Marie Lønberg , Thomsen Katja , Søborg Henrik , Jensen Helle Oldrup , Almdal Thomas Peter , Lorenzen Janne Kunchel , Hansen Anders Blædel Gottlieb , Ried-Larsen Mathias 
Published: August 2024

AbstractBackgroundPublic physical activity programs are time-limited and often lacking sufficient support for citizens to maintain physical activity engagement. In this project, municipal stakeholders; civil society organizations; citizens with type 2 diabetes (T2D), cardiovascular diseases (CVD), and/or obesity; and researchers were involved in the co-creation and implementation of interventions to support citizens in continuing physical activity engagement following a municipal rehabilitation program. The primary aim of this study was to investigate the effect of these interventions on physical activity engagement in civil society sports organizations. Secondary aims were to investigate acceptability and effect of these interventions on physical and mental health, and organizational development and collaboration.MethodsThis was a convergent mixed methods study using a quantitative prospective intervention study with a historic control group, and a qualitative descriptive study. These were analyzed separately and then integrated. Quantitative data from citizens were collected before; and 0, 3 and 6 months after ending their rehabilitation program. Outcomes included physical activity engagement in civil society organizations; and changes in objectively measured physical activity, physical and mental health. Qualitative data were collected among citizens, civil society, and municipal representatives. Themes included physical activity engagement, acceptability, and organizational development and collaboration.ResultsAmong the 33 included citizens (58% women, median (25th; 75thpercentile) age of 67.6 (63.9; 74.1) years), six lived with T2D; nine with CVD; and 18 were obese. Of the 21 citizens who were not engaged in physical activities in civil society organizations before entering the rehabilitation program, 67% started and remained active at 6-month follow-up—significantly more than in the historic control group. Light physical activity increased by a mean (95% confidence interval) of 15.4 (2.3; 28.5) min/day from 0 to 6 months after the rehabilitation program; all other outcomes remained unchanged. This was assisted by experienced high acceptability of the linking interventions and strengthened collaboration between the municipal health center and civil society organizations.ConclusionsThe co-created interventions led to increased physical activity engagement in civil society organizations. This supports co-creation as a method to link municipal rehabilitation programs with physical activities in civil society organizations.Trial registrationClinicalTrials.gov:NCT05493345, 2022-08-05
Patterns of antidepressant prescribing in and around pregnancy: a descriptive analysis in the UK Clinical Practice Research Datalink
Authors: Martin Florence Z. , Sharp Gemma C. , Easey Kayleigh E. , Madley-Dowd Paul , Bowen Liza , Nimmo-Smith Victoria , Sadik Aws , Richardson Jonathan L. , Rai Dheeraj , Forbes Harriet 
Published: August 2024

AbstractObjectiveTo describe the prevalence and patterns of antidepressant prescribing in and around pregnancy.DesignDrug utilisation study.SettingPrimary care in the United Kingdom (UK).PopulationWomen with a pregnancy between 1996 and 2018 in the UK Clinical Practice Research Datalink (CPRD) GOLD Pregnancy Register.MethodsUsing primary care prescription records, we identified individuals who had been prescribed antidepressants in and around pregnancy and described changing prevalence of prescribing during pregnancy over time. We defined ‘prevalent’ or ‘incident’ antidepressant use, where ‘prevalent’ users were prescribed antidepressants both before and during pregnancy, and ‘incident’ users were newly prescribed antidepressants during pregnancy, then compared patterns of prescribing between these two groups. We also investigated characteristics associated with antidepressant discontinuation anytime during pregnancy and post-pregnancy prescribing.Main outcome measuresAntidepressant prescribing during pregnancy.ResultsA total of 1,033,783 pregnancies were identified: 79,144 (7.7%) were prescribed antidepressants during pregnancy and 15,733 of these (19.9%) were ‘incident’ users. Antidepressant prescribing during pregnancy increased from 3.2% in 1996 to 13.4% in 2018. Most women, both ‘prevalent’ and ‘incident’ users, discontinued antidepressants anytime during pregnancy (54.8% and 59.9%, respectively). The majority of those who discontinued during pregnancy resumed in the 12 months after pregnancy (53.0%). Younger age, previous stillbirth, and higher deprivation were associated with more frequent discontinuation anytime during pregnancy.ConclusionsAntidepressant use during pregnancy appears to be increasing in the UK. Most women discontinued antidepressants at some point before the end of pregnancy, but post-pregnancy resumption of antidepressants was common.FundingWellcome Trust 218495/Z/19/Z.
Tunable topological magnetism in superlattices of nonmagnetic B20 systems
Authors: Borisov Vladislav , Delin Anna , Eriksson Olle 
Published: August 2024

We predict topological magnetic properties of B20 systems, that are organized in atomically thin multilayers. In particular, we focus on FeSi/CoSi and FeSi/FeGe superlattices with different numbers of layers and interface structures. We demonstrate that the absence of long-range magnetic order, previously observed in bulk FeSi and CoSi, is broken near the FeSi/CoSi interface, where a magnetic state with a nontrivial topological texture appears. Using the Heisenberg and Dzyaloshinskii-Moriya (DM) interactions calculated from first principles, we perform finite-temperature atomistic spin dynamics simulations for up to 2×106 spins to capture the complexity of noncollinear textures. Our simulations predict the formation of antiskyrmions in a [001]-oriented FeSi/CoSi multilayer, intermediate skyrmions in a [111]-oriented FeSi/CoSi system, and Bloch skyrmions in the FeSi/FeGe (001) system, with a size between 7 and 37 nm. These varieties of topological magnetic textures in the studied systems can be attributed to the complex asymmetric structure of the DM matrix, which is different from previously known magnetic materials. We demonstrate that through structural engineering both ferromagnetic and antiferromagnetic skyrmions can be stabilized, where the latter are especially appealing for applications due to the zero skyrmion Hall effect. The proposed B20 multilayers show a potential for further exploration and call for experimental confirmation.

Published by the American Physical Society
2024
Airports in Turkey: efficiency limits and the role of technological change
Authors: Ekici Filiz , Gümüş Öner , Orhan Ilkay 
Published: August 2024

Purpose
This paper aims to present an example of the measurement of airport efficiency, a topic of great interest in civil aviation today. The methodology used is data envelopment analysis (DEA) and the Malmquist Index. The calculation of airport efficiency with up-to-date data for each period is of great importance in the context of sustainability. The study selected ten airports with high air traffic in Turkey as the sample set. The objective of this study is to evaluate the current state of airport efficiency, identify the sources of inefficiency and make appropriate policy recommendations based on the findings obtained.

Design/methodology/approach
The study is based on DEA and Malmquist Index Analysis. The number of personnel and terminal size data of ten selected decision-making units (DMU) are used as inputs, while passenger, cargo and aircraft traffic data are used as outputs. A five-year period, spanning from 2018 to 2022, is considered as the data set in the study.

Findings
Upon analysis of the data from the ten airports included in the study, it was found that the current input-output combination yielded efficient results, with the exception of certain characteristics, such as the impact of seasonal conditions or tourism. Concurrent with the growth in aircraft, passenger and freight traffic, the number of personnel employed at these airports has also increased. It was concluded that technological efficiency is of paramount importance for each airport, and that investments in technology should be increased.

Practical implications
A separate assessment was conducted for each of the ten airports included in the study sample. Each airport was evaluated in terms of its strengths and weaknesses, and areas of low efficiency were identified. Consequently, more general conclusions were reached than airport-specific evaluations.

Originality/value
In order to ensure the long-term sustainability of the sector, it is essential that the efficiency measurements of airports are calculated using up-to-date data on a regular basis. The results obtained from these calculations provide guidance for the strategic plans to be implemented in the long term, as well as for the solution proposals for operational problems. In this context, this study not only provides information to policymakers and airport managers about the current situation, as it includes recent data, but also contributes to the literature in this sense, as it includes policy recommendations.