bluuebunny/crossref_metadata_2025_split huggingface dataset:
A (101¯0$10\bar{1}0$)‐Orientated ZnO Single Crystal Chem‐Voltaic Device Beyond Conventional Fuel Cells
Authors: Meng Xiaohua , Liu Bin , Yang Heqing , Liu Shengzhong 
Published: July 2024

AbstractTo date, new prototype device for directly converting chemical energy into electricity is still the most important pursuit although various types of fuel cells have been developed/commercialized. In this work, a novel () orientated ZnO single crystal device is reported that generates electricity using the usual redox reactions. The principle of the device is similar to that of a photovoltaic device, known as a chem‐voltaic device. The air‐KBH4 chem‐voltaic device has an open‐circuit voltage (Voc) of 2.14 ± 0.007 mV and a short‐circuit current (Isc) of 1.44 ± 0.007 µA. The Voc and Isc increase to 2.24 mV and 2.81 µA, respectively, by preadding H2O2. A similar phenomenon is also observed when glucose is used to substitute KBH4. When KBH4 or glucose solution is added to the ZnO () surface, it reacts with chemisorbed oxygen to produce free electrons. Due to the presence of the spontaneous electric field (Es) in the polar [0001] azimuth of ZnO, these free electrons move along the [0001] direction, producing an electric current. So chemical energy is converted into electricity. This finding opens up research on the chem‐voltaic cell.
Unconventional Ligand‐to‐Catalyst Ratio for the Distal C−C Bond Formation via C−H Activation and Chain‐Walking
Authors: Tang King Hung Nigel , Takahashi Haluhi , Tokutake Ryo , Shibata Takanori 
Published: July 2024

AbstractA mechanism‐navigated enantioselective alkylation of an indole C2 C−H bond with an internal alkene was developed. Under the unconventional ligand‐to‐metal catalyst ratio, a moderate enantiomeric ratio (er), ranging from 70:30 to 88:12, was achieved with our original ligand. We propose that chain‐walking and bond formation are mechanistically independent and suggest that hydridoiridium generated from the C−H source does not play a role in the chain‐walking process.
Synthesis of Chromone‐3‐phosphonates via Arbuzov‐Type C−P Cross Coupling from o‐Hydroxyphenyl Enaminones and Phosphites
Authors: Cao Dingsheng , Wan Jie‐Ping , Liu Yunyun 
Published: July 2024

AbstractWith an in situ C−H iodination tactic, a method for the synthesis of chromone‐3‐phosphonates was developed with trialkyl/triaryl phosphites as the reaction partners of o‐hydroxyphenyl enaminones by palladium catalysis. The product formation consists of cascade C−H iodination, chromone annulation, and Arbuzov‐type C−P cross coupling as major transformations. In addition to providing an enaminone‐based synthetic method to chromone‐3‐phosphonates, the work shows the advantage of step economy by skipping the separate operation for preparing the iodo‐functionalized chromone intermediate.
Conjugated Carbonyl Compound‐Enhanced Hydrogels for Tactile Recognition
Authors: Zhan Xue‐Qing , Chen Han , Hong Zhi‐Ling , Leng Yong‐Ping , Zhu Chang‐Chang , Zhang Chang‐Bo , Tang Zhong‐Xiang , Chen Qian , Ma Ning , Tsai Fang‐Chang 
Published: July 2024

AbstractHydrogels that possess both self‐healing capabilities in tissue engineering and mechanical properties play a pivotal role in advancing flexible sensing and wearable bioelectronic devices technologies. The primary challenge in practical applications revolves around the delicate equilibrium between mechanical properties and self‐regeneration capabilities. Herein, the utilization of conjugated carbonyl compound PI‐COF (Polyimide‐Covalent organic framework) is proposed as reinforcing phases to interact with iron ions, thereby preparing PAA‐based double network hydrogel with high cross‐linking density. Through comprehensive component analysis, it has been determined that the existence of metal coordination bonds, hydrogen bonds along with π–π conjugate system imparts (PAA‐2DC)‐Fe3+/PEDOT: PSS hydrogel excellent self‐healing performance (3rd, 196.2%), elongation (1312%) and tensile strength (71 kPa). Additionally, the hydrogel exhibits remarkable conductivity (σ = 0.5 S m−1), strain sensing sensitivity (GF = 9.3), self‐adhesive properties and demonstrating its ability to differentiate between materials of various sizes and possesses antibacterial properties. These exceptional attributes highlight the potential of the hydrogel in tissue engineering and flexible sensing, simultaneously providing novel research ideas and theoretical basis.
Central nervous system multiple myeloma: A real‐world multi‐institutional study of the Greek Myeloma Study Group
Authors: Katodritou Eirini , Dalampira Dimitra , Delimpasi Sosana , Ntanasis‐Stathopoulos Ioannis , Karaolidou Fryni , Gkioka Annita‐Ioanna , Labropoulou Vasiliki , Spanoudakis Emmanouil , Triantafyllou Theodora , Kotsopoulou Maria , Michalis Eyrydiki , Vadikolia Chrysanthi , Papadopoulou Theodosia , Sevastoudi Aggeliki , Michael Michael , Daiou Aikaterini , Pentidou Aikaterini , Kostopoulos Ioannis , Palaska Vasiliki , Gavriatopoulou Maria , Kyrtsonis Marie‐Christine , Verrou Evgenia , Kastritis Efstathios , Dimopoulos Meletios‐Athanasios , Terpos Evangelos 
Published: July 2024

AbstractCentral nervous system (CNS) involvement is a rare and aggressive complication of multiple myeloma (MM). We identified 54/4352 MM patients (1.2%), who developed CNS‐MM between 2000 and 2022. A matched‐control group of MM patients without CNS‐MM was used for comparisons. Median age was 63 years. Median time to CNS‐MM was 28 months; 6/54 experienced CNS‐MM at MM diagnosis. Abnormal lactate dehydrogenase (LDH), high‐risk cytogenetics, and extramedullary involvement (EMI), that is, soft tissue plasmacytomas and/or plasma cell leukemia (PCL), were more frequent in CNS‐MM versus controls (p < .05); 13/54 had PCL at CNS‐MM. The majority had leptomeningeal infiltration (LMI) (66%); 26% had CNS‐MM without systemic myeloma; EMI was the strongest predictor for CNS‐MM (OR: 6.3). Median overall survival (OS) of CNS‐MM patients versus controls was 43 months (95% CI: 32–54) versus 60 months (95% CI: 38–82) (p < .001); treatment of CNS‐MM included mainly bortezomib/thalidomide/chemotherapy whereas 20% received novel drugs/immunotherapy combinations; 28 patients underwent cerebrospinal fluid infusions; EMI was the strongest negative predictor for post CNS‐MM OS (p = .005; HR: 2.9). Treatment after 2016 predicted significantly for OS (p = .002; HR: 0.27). Median post CNS‐MM OS was 4 months (95% CI: 2.6–5.4); in patients treated after 2016 median OS was 12 months. In conclusion, we have demonstrated in this large real‐world series that survival of CNS‐MM remains poor; however, there is a positive impact of treatment after 2016, related to the efficacy of modern anti‐myeloma therapy; EMI significantly increases the probability to develop CNS‐MM and the risk of post CNS‐MM death, indicating a potential need for CNS prophylaxis for those patients.
Thermal oxidation of aviation lubricating oil: Mechanism, influencing factors, evaluation methods, and antioxidants
Authors: Zhang Xiaojin , Huang Xi , Li Jing , Tang Zhongping , Wang Jiangbing 
Published: July 2024

AbstractAviation lubricating oil, as the “blood of machine operation”, plays an important role in the lubrication, cooling, cleaning, sealing, rust prevention, and other aspects of aero‐engines, thereby ensuring the safe and stable long‐term endurance of aero‐engines under high‐speed and high‐temperature conditions. The thermal oxidation of aviation lubricating oil leading to decay is the most important factor causing lubricating oil failure, which will seriously affect the performance of aero‐engines and endanger flight safety. Here, we comprehensively summarize the oxidation mechanism of aviation lubricating oil, factors affecting thermal oxidation of aviation lubricating oil, evaluation methods for thermal oxidation of aviation lubricating oil, and antioxidants that inhibit thermal oxidation of aviation lubricating oil. We hope that this review can enhance readers' understanding of the thermal oxidation of aviation lubricating oil, stimulate broader interest, and promote more exciting development in this promising field.
Physicochemical Studies on Amino Acid Based Metallosurfactants in Combination with Phospholipid
Authors: Barai Manas , Manna Emili , Sultana Habiba , Mandal Manas Kumar , Manna Tuhin , Patra Anuttam , Roy Biplab , Gowda Vasantha , Chang Chien‐Hsiang , Akentiev Alexander V. , Bykov Alexey G. , Noskov Boris A. , Moitra Parikshit , Ghosh Chandradipa , Yusa Shin‐Ichi , Bhattacharya Santanu , Kumar Panda Amiya 
Published: July 2024

AbstractDicarboxylate metallosurfactants (AASM), synthesized by mixing N‐dodecyl aminomalonate, ‐aspartate and ‐glutamate with CaCl2, MnCl2 and CdCl2, were characterized by XRD, FTIR, and NMR spectroscopy. Layered structures, formed by metallosurfactants, were evidenced from differential scanning calorimetry and thermogravimetric analyses. Solvent‐spread monolayer of AASM in combination with soyphosphatidylcholine (SPC) and cholesterol (CHOL) were studied using Langmuir surface balance. With increasing mole fraction of AASM mean molecular area increased and passed through maxima at ~60 mol% of AASMs, indicating molecular packing reorganization. Systems with 20 and 60 mol% AASM exhibited positive deviations from ideal behavior signifying repulsive interaction between the AASM and SPC, while synergistic interactions were established from the negative deviation at other combinations. Dynamic surface elasticity increased with increasing surface pressure signifying formation of rigid monolayer. Transition of monolayer from gaseous to liquid expanded to liquid condensed state was established by Brewster angle microscopic studies. Stability of the hybrid vesicles, formed by AASM+SPC+CHOL, were established by monitoring their size, zeta potential and polydispersity index values over 100 days. Size and spherical morphology of hybrid vesicles were confirmed by transmission electron microscopic studies. Biocompatibility of the hybrid vesicles were established by cytotoxicity studies revealing their possible applications in drug delivery and imaging.
Proximity‐Dependent Activation of Split DNAzyme Kinase
Authors: Wang Jiayi , Chang Yangyang , Liu Meng 
Published: July 2024

AbstractBinary (also known as split) nucleic acid enzymes have emerged as novel tools in biosensors. We report a new split strategy to split the DNAzyme kinase into two independent and non‐functional fragments, denoted Dk1sub and Dk1enz. In the presence of the specific target, their free ends are brought sufficiently close to interact with each other without the formation of Watson‐Crick base pairings between Dk1sub and Dk1enz, thus allowing the DNA phosphorylation reaction. We term this approach proximity‐dependent activation of split DNAzyme kinase (ProxSDK). The utility of ProxSDK is demonstrated by engineering a biosensing system that is capable of measuring specific DNA‐protein interactions. We envision that the approach described herein will find useful applications in biosensing, imaging, and clinical diagnosis.
Tandem Synthesis of Benzylidenemalononitrile Derivatives in/on Water under Visible Light
Authors: Kolb Daniel , Friedmann Kai , König Burkhard 
Published: July 2024

AbstractTandem processes are valuable tools that allow to build molecular complexity while reducing waste production and the number of steps of synthetic routes. In this work, the in situ photooxidation of benzyl alcohols to the corresponding benzaldehydes is coupled with a Knoevenagel condensation for the preparation of benzylidenemalononitrile derivatives. In this rapid one‐pot tandem process, sodium anthraquinone‐1,5‐disulfonate (SAS) and β‐alanine are employed as safe and inexpensive catalysts, while air is used as a terminal oxidant. Moreover, using water as reaction medium results in most cases in the precipitation of the target products, thus facilitating their isolation.
Firefly Interval Selection Combined With Extreme Learning Machine for Spectral Quantification of Complex Samples
Authors: Wang Shuyu , Zhang Xudong , Mpango Prisca , Sun Hao , Bian Xihui 
Published: July 2024

ABSTRACTFirefly algorithm (FA) combined with extreme learning machine (ELM) is developed for spectral interval selection and quantitative analysis of complex samples. The method firstly segments the spectra into a certain number of intervals. Vectors with 1 and 0, which represent the interval selected or not, are used as the inputs of the FA. The RMSEP value predicted by ELM model is used as the fitness function of the FA. The activation function and number of hidden layer nodes of ELM, number of spectral intervals, population number, environmental absorbance, and constant of FA are optimized. The predictive performance of FA‐ELM is compared with full‐spectrum PLS, ELM, genetic algorithm‐ELM (GA‐ELM), and particle swarm optimization‐ELM (PSO‐ELM) by one ultraviolet (UV) spectrum dataset of gasoil and three near‐infrared (NIR) spectral datasets of corn, wheat, and tablet samples. The results show that FA‐ELM has a better performance compared with its competitors in predicting monoaromatics, water, wheat kernel texture, and active pharmaceutical ingredients (APIs) in gasoil, corn, wheat, and tablet samples.
Monomeric Fe(III)‐Hydroxo and Fe(III)‐Aqua Complexes Display Oxidative Asynchronous Hydrogen Atom Abstraction Reactivity
Authors: Molla Mofijul , Saha Anannya , Barman Suman K. , Mandal Sukanta 
Published: July 2024

AbstractThis paper presents the synthesis and characterization of a series of novel monomeric aqua‐ligated iron(III) complexes, [FeIII(L5R)(OH2)]2+ (R=OMe, H, Cl, NO2), supported by an amide‐containing pentadentate N5 donor ligand, L5R [HL5R=2‐(((1‐methyl‐1H‐imidazol‐2‐yl)methyl)(pyridin‐2‐yl‐methyl)amino)‐N‐(5‐R‐quinolin‐8‐yl)acetamide]. The complexes were characterized by various spectroscopic and analytical techniques, including electrochemistry and magnetic measurements. The Fe(III)‐hydroxo complexes, [FeIII(L5R)(OH)]1+, were generated in situ by deprotonating the corresponding aqua complexes in a pH ~7 aqueous medium. In another way, adding one equivalent of a base to a methanolic solution of the Fe(III)‐aqua complexes also produced the Fe(III)‐hydroxo complexes. The study uses linoleic fatty acid as a substrate to explore the hydrogen atom abstraction (HAA) reactivity of both hydroxo and aqua complexes. The investigation highlights the substitution effect of the L5R ligand on reactivity, revealing a higher rate when an electron‐withdrawing group is present. Hammett analyses and(or) determination of the asynchronicity factor (η) suggest an oxidative asynchronous concerted proton‐electron transfer (CPET) pathway for the HAA reactions. Aqua complexes exhibited a higher asynchronicity in CPET, resulting in higher reaction rates than their hydroxo analogs. Overall, the work provides insights into the beneficial role of a higher imbalance in electron‐transfer‐proton‐transfer (ET‐PT) contributions in HAA reactivity.
The Influence of Disulfide, Thioacetal and Lanthionine‐Bridges on the Conformation of a Macrocyclic Peptide
Authors: Darling William T. P. , Wieske Lianne H. E. , Cook Declan T. , Aliev Abil E. , Caron Laurent , Humphrys Emily J. , Figueiredo Angelo Miguel , Hansen D. Flemming , Erdélyi Máté , Tabor Alethea B. 
Published: July 2024

AbstractCyclisation of peptides by forming thioether (lanthionine), disulfide (cystine) or methylene thioacetal bridges between side chains is established as an important tool to stabilise a given structure, enhance metabolic stability and optimise both potency and selectivity. However, a systematic comparative study of the effects of differing bridging modalities on peptide conformation has not previously been carried out. In this paper, we have used the NMR deconvolution algorithm, NAMFIS, to determine the conformational ensembles, in aqueous solution, of three cyclic analogues of angiotensin(1–7), incorporating either disulfide, or non‐reducible thioether or methylene thioacetal bridges. We demonstrate that the major solution conformations are conserved between the different bridged peptides, but the distribution of conformations differs appreciably. This suggests that subtle differences in ring size and bridging structure can be exploited to fine‐tune the conformational properties of cyclic peptides, which may modulate their bioactivities.
Real‐World Clinical Performance of a Novolimus‐Eluting Stent Versus a Sirolimus‐Eluting Stent
Authors: Chang Chun‐Chin , Sung Wei‐Ting , Lu Ya‐Wen , Chuang Ming‐Ju , Lee Yin‐Hao , Tsai Yi‐Lin , Chou Ruey‐Hsing , Huang Shao‐Sung , Huang Po‐Hsun 
Published: July 2024

ABSTRACTIntroductionThe DESyne novolimus‐eluting coronary stent (NES) is a new‐generation drug‐eluting stent (DES) that is widely used, but clinical data are rarely reported for this stent. We compared the safety and effectiveness of the DESyne NES and the Orsiro bioresorbable polymer sirolimus‐eluting stent (SES) in patients undergoing percutaneous coronary intervention (PCI).MethodsThis was a retrospective, single‐center, observational study. Between July 2017 and December 2022, patients who presented with chronic or acute coronary syndrome undergoing PCI with DESyne NES or Orsiro SES were consecutively enrolled in the present study. The primary endpoint, major adverse cardiovascular event (MACE), was a composite of cardiovascular death, target‐vessel myocardial infarction, or clinically driven target‐lesion revascularization.ResultsA total of 776 patients (age 68.8 ± 12.2; 75.9% male) undergoing PCI were included. Overall, 231 patients with 313 lesions received NES and 545 patients with 846 lesions received SES. During a follow‐up duration of 784 ± 522 days, the primary endpoint occurred in 10 patients (4.3%) in the NES group and in 36 patients (6.6%) in the SES group. After multivariate adjustment, the risk of MACE did not significantly differ between groups (NES vs. SES, hazard ratio 0.74, 95% CI, 0.35–1.55, p = 0.425). The event rate of individual components of the primary endpoint was comparable between the two groups.ConclusionsFavorable and similar clinical outcomes were observed in patients undergoing PCI with either NES or SES in a medium‐term follow‐up duration. Future studies with adequately powered clinical endpoints are required for further evaluation.
The continuous adjoint method to the γ−R˜eθt$$ \gamma -\tilde{R}{e}_{\theta t} $$ transition model coupled with the Spalart–Allmaras model for compressible flows
Authors: Kontou Marina G. , Trompoukis Xenofon S. , Asouti Varvara G. , Giannakoglou Kyriakos C. 
Published: July 2024

AbstractThe continuous adjoint method for transitional flows of compressible fluids is developed and assessed, for the first time in the literature. The gradient of aerodynamic objective functions (aerodynamic forces) with respect to design variables, in problems governed by the compressible Navier–Stokes equations coupled with the Spalart–Allmaras turbulence model and the transition model (in three, non‐smooth and smooth, variants of it), is computed based on the continuous adjoint method. The development of the adjoint to the smooth transition model variant proved to be beneficial. The accuracy of the computed sensitivity derivatives is verified against finite differences. Programming is performed in an in‐house, vertex‐centered finite‐volume code, efficiently running on GPUs. The proposed continuous adjoint method is used in 2D and 3D aerodynamic shape optimization problems, namely the constrained optimization of the NLF(1)–0416 isolated airfoil and that of the ONERA M6 wing. The impact of “frozen transition” (assumption according to which the adjoint to the transition model equations are not solved) or “frozen turbulence” (by additionally ignoring the adjoint to the turbulence model) are evaluated; it is shown that both lead to inaccurate sensitivities.
Harnessing the power of empathy, visual art and patient narratives to improve health literacy: An exploratory study
Authors: Beck Tracey , Giese Steven , Khoo Tien K. 
Published: July 2024

AbstractIssue AddressedHealth‐related information can often be overwhelming for consumers, frequently infused with complex medical terminology that is difficult to understand and apply. Historically empathic connection, art and narratives have played key roles in communicating with diverse populations however collectively have received little recognition as a modality to improve health literacy. This study aimed to investigate the empathetic connection between art and patient narratives with a view to improve health literacy in the wider community.MethodsNine recently discharged patients and one carer from a regional hospital were paired with 10 tertiary visual arts students for interview. Each narrative was transformed into visual art and exhibited at a community art gallery. The Empathy Quotient (EQ), Medical Outcomes Study 36‐item Short Form Health Survey (SF‐36) and self‐completed questionnaires assessed empathy and functional well‐being. Health literacy was evaluated through community response surveys post‐exhibition exposure.ResultsStudent artist participants' EQ Cognitive Empathy (EQ‐CE) scores were associated with ‘Emotional Reactivity’ (EQ‐ER) (p = .038). SF‐36 scores revealed that role limitations due to physical health and emotional problems had the greatest impact on patient/carer participant's life at the time. The SF‐36 General Health domain was associated with the EQ‐ER total score (p = .044). Exhibition surveys revealed that 96.9% of observers had learnt something new about illness or injury.So What?Although a relatively small study, our findings suggest patient/carer narratives and visual art is a simple yet effective modality for health service organisations to facilitate affective learning and improve health literacy when engaging with consumers.
Assessing the efficacy of manual reduction and novel traction techniques for distal radius fractures: A randomized controlled trial
Authors: Majidi Morteza , Rohani Erfan , Chamani Vahid , Rezaei Mehdi , Roostayi Mohammad Mohsen , Ghaznavi Alireza , Khosravi Mobina 
Published: July 2024

AbstractBackground and AimOne of the leading reasons that patients, particularly older persons, are brought to the orthopedic emergency room is a fracture at the end of the radius. In this study, a new traction method for distal radius fractures was compared with manual reduction.MethodsThe census method was used in this clinical trial to study 45 patients (46 hands) who were referred to Hamedan Besat Hospital in 2021. Patients were randomly assigned to two groups. The manual reduction (pressure and traction by an assistant and a doctor) method was implemented in Group A, and the new traction procedure (pressure and traction by hardware or a device) was performed in Group B. The radiographic results of reduction in both groups were investigated and compared immediately and in the first and 6 weeks after surgery.ResultsThe following results were observed in the new and manual groups in the sixth week after surgery: average volar tilt: 4.19 ± 3.79 and 4.08 ± 3.88 (p = 0.926), radial angulation: 2.18 ± 1.27 and 2.21 ± 1.35 (p = 0.934), radial shortening: 10.52 ± 0.65 and 10.56 ± 0.68 (p = 0.828), radial inclination: 22.52 ± 2.46 and 22.71 ± 2.01 (p = 0.787), dorsal angulation: −5.89 ± 0.33 and 5.22 ± −1.91 (p = 1.00), ulnar variance: 1.66 ± 0.90 and 1.67 ± 0.81 (p = 0.958), and average pain score: 2.40 ± 0.68 and 2.47 ± 0.73 (p = 0.737).ConclusionThe new reduction procedure with hardware in patients with distal radius fractures showed the same effect as the traditional method based on pressure and traction by the assistant and doctor in terms of radiographic changes and pain score of the fracture site.