bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Pyrrole: A Resourceful Small Molecule in Key Medicinal Hetero‐Aromatics
Authors: Bhardwaj Varun , Gumber Divya , Abbot Vikrant , Dhiman Saurabh , Sharma Poonam 
Published: April 2015

AbstractReview: approaches to synthesize pyrrole and pyrrole containing analogues, structure—activity relationship studies and therapeutic applications reported during the last decade; 137 refs.
ChemInform Abstract: Gold‐Catalyzed Atom‐Economical Cascade Reactions of Alkynes for Ring Formation
Authors: Ohno Hiroaki , Oishi Shinya , Fujii Nobutaka 
Published: April 2015

AbstractReview: development of gold‐catalyzed cascade reactions for atom‐economical synthesis f fused carbazoles, naphthalenes, dihydropyrazoles/indazoles and indoloquinoline s; 61 refs.
ChemInform Abstract: Catalyst Design with Atomic Layer Deposition
Authors: O'Neill Brandon J. , Jackson David H. K. , Lee Jechan , Canlas Christian , Stair Peter C. , Marshall Christopher L. , Elam Jeffrey W. , Kuech Thomas F. , Dumesic James A. , Huber George W. 
Published: April 2015

AbstractReview: 247 refs.
ChemInform Abstract: The Yin and Yang in the Development of Catalytic Processes: Catalysis Research and Reaction Engineering
Authors: Prieto Gonzalo , Schueth Ferdi 
Published: April 2015

AbstractReview: [interplay of catalyst chemistry and reaction engineering for processes such as the sulfuric acid production, ammonia synthesis, methanol synthesis, fluid catalytic cracking, and direct epoxidation of propylene at BASF; 106 refs.
2‐Substituted 6‐(Het)aryl‐7‐deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity
Authors: Malnuit Vincent , Slavětínská Lenka Poštová , Nauš Petr , Džubák Petr , Hajdúch Marián , Stolaříková Jiřina , Snášel Jan , Pichová Iva , Hocek Michal 
Published: April 2015

AbstractA series of 6‐(hetero)aryl‐ or 6‐methyl‐7‐deazapurine ribonucleosides bearing a substituent at position 2 (Cl, F, NH2, or CH3) were prepared by cross‐coupling reactions at position 6 and functional group transformations at position 2. Cytostatic, antiviral, and antimicrobial activity assays were performed. The title compounds were observed to be potent and selective inhibitors of Mycobacterium tuberculosis adenosine kinase (ADK), but not human ADK; moreover, they were found to be non‐cytotoxic. The antimycobacterial activities against M. tuberculosis, however, were only moderate. The reason for this could be due to either poor uptake through the cell wall or to parallel biosynthesis of adenosine monophosphate by the salvage pathway.
Toll‐Like Receptor 7 Inactive Ligands Enhanced Cytokine Induction by Conjugation to Weak Antigens
Authors: Gao Dong , Diao Yuwen , Li Wang , Gao Ningning , Liu Yu , Wang Zhulin , Jiang Wenqi , Jin Guangyi 
Published: April 2015

AbstractToll‐like receptors (TLRs) 7/8 are key targets in the design and development of small‐molecule drugs serving as anticancer/antiviral agents and vaccine adjuvants. Clinical trials of imiquimod were discontinued owing to its serious adverse side effects. Herein we report the synthesis and biological evaluation of a series of 8‐hydroxy‐2‐(2‐methoxyethoxy)adenine derivatives that cannot induce cytokine production and that lack activity toward TLR 7/8. Their ability to triggering remarkable levels of cytokine production were revealed upon their conjugation with antigens that have weak immunogenicity. This discovery demonstrated that TLR 7 can be activated by coupling an antigen to the terminal carboxyl group at N9 of the inactive ligand adenine analogues. These inactive analogues may be well suited as new adjuvants with superior activity after conjugation, effectively decreasing the side effects caused by conventional adjuvants.
Two Structure Types Based on Si6O15 Rings: Synthesis and Structural and Spectroscopic Characterisation of Cs1.86K1.14DySi6O15 and Cs1.6K1.4SmSi6O15
Authors: Wierzbicka‐Wieczorek Maria , Göckeritz Martin , Kolitsch Uwe , Lenz Christoph , Giester Gerald 
Published: April 2015

AbstractThe silicate Cs1.86K1.14DySi6O15 represents a mixed tetrahedral‐octahedral framework structure type based on roughly circular Si6O15 rings and isolated DyO6 octahedra. The silicate Cs1.6K1.4SmSi6O15 has a layered atomic arrangement built from corrugated Si6O15 layers containing four‐, six‐ and eight‐membered rings. The layers are connected by isolated SmO6 octahedra to form a mixed tetrahedral‐octahedral framework. This structure shows a close structural relationship to β‐K3NdSi6O15 and a less close one to dehydrated elpidite (Na2ZrSi6O15). In both structures, Cs/K atoms occupy large voids. The silicates were obtained through high‐temperature flux syntheses. Their crystal structures have been determined from single‐crystal X‐ray diffraction data. Cs1.86K1.14DySi6O15 crystallises in R32 (no. 155) with a = 13.896(2), c = 35.623(7) Å and V = 5957.2(17) Å3, whereas Cs1.6K1.4SmSi6O15 crystallises in Cmca (no. 64) with a = 14.474(3), b = 14.718(3), c = 15.231(3) Å and V = 3244.7(11) Å3. The Dy3+ and Sm3+ cations present in the silicates cause PL emission bands in the visible yellow‐to‐orange spectral range.
Dopamine Electroanalysis Using Electrochemical Biosensors Prepared by a Sinusoidal Voltages Method
Authors: Lupu Stelian , Lete Cecilia , Javier del Campo Francisco 
Published: April 2015

AbstractA biocomposite material of tyrosinase and poly(3,4‐ethylenedioxythiophene) was electrodeposited onto gold (Au) disk microelectrode arrays and Au interdigitated microband electrode arrays (IDEs) by using a combination of sinusoidal voltages and microgravimetric method to construct amperometric biosensors for dopamine (DA). The main advantage of this new strategy consists in a reliable enzyme immobilization and in additional information related to the electropolymerization process. The determination of DA was successfully achieved in pharmaceutical formulations. The best analytical performances, in terms of the lowest limit of detection of 6×10−7 M DA and highest recovery and stability, were obtained for IDEs based biosensor.
Multiwalled Carbon Nanotubes‐Chitosan Modified Single‐Use Biosensors for Electrochemical Monitoring of Drug‐DNA Interactions
Authors: Sengiz Ceren , Congur Gulsah , Eksin Ece , Erdem Arzum 
Published: April 2015

AbstractA multiwalled carbon nanotubes (CNT)‐chitosan (CHIT) modified pencil graphite electrode (CNT‐CHIT/PGE) was developed for the first time herein for electrochemical monitoring of the interaction of an anticancer drug, mitomycin C (MC) and DNA. The characterization of unmodified PGE, CHIT/PGE, CNT/PGE and CHIT‐CNT/PGE were performed by scanning electron microscopy and cyclic voltammetry techniques. The oxidation signals of MC and guanine were measured before and after interaction at the surface of CNT‐CHIT/PGEs using differential pulse voltammetry. Electrochemical impedance spectroscopy technique was also successfully utilized for monitoring of the interaction process at the surface of CNT‐CHIT/PGEs in different interaction times.
Two New Phenylethanoid Glycosides from Callicarpa longissima
Authors: Yuan Jing‐Quan , Qiu Li , Zou Lu‐Hui , Wei Qian , Miao Jian‐Hua , Yao Xin‐Sheng 
Published: April 2015

AbstractTwo new phenylethanoid glycosides, longissimosides A and B (1 and 2, resp.), together with eight structurally related known compounds, were isolated from the EtOH extract of leaves and stems of Callicarpa longissima (Hemsl.) Merr. The structures of 1 and 2 were elucidated as 2‐(3,4‐dihydroxyphenyl)ethyl O‐(α‐L‐rhamnopyranosyl)‐(1→3)‐O‐(2‐O‐syringoyl‐β‐D‐xylopyranosyl)‐(1→6)‐ 4‐O‐[(E)‐caffeoyl]‐β‐D‐glucopyranoside (1) and 2‐(3‐hydroxy‐4‐methoxyphenyl)ethyl O‐(α‐L‐rhamnopyranosyl)‐(1→3)‐O‐(β‐D‐apiofuranosyl)‐(1→6)‐4‐O‐[(E)‐isoferuloyl]‐β‐D‐glucopyranoside (2) on the basis of spectroscopic data and acid hydrolysis.
New Phenolic Tricyclic Diterpenoids from Rhizomes of Isodon hispida (Benth.) Hara
Authors: Huang Bo , Huang Zhen‐Yuan , Xiao Chao‐Jiang , Dong Xiang , Jiang Bei 
Published: April 2015

AbstractThree new phenolic tricyclic diterpenoids, including two sempervirane diterpenoids, hispidanols A and B (1 and 2, resp.), and one totarane diterpenoid, totara‐8,11,13‐triene‐13→16‐hemiacetal (3), along with 14 known compounds, 4–17, were isolated from the AcOEt‐soluble fraction of the 70%‐acetone extract of rhizomes of Isodon hispida. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties.
Copper‐Catalyzed Synthesis of Pentasubstituted Pyridines from N‐Sulfonyl Ketenimines, 1,1,3,3‐Tetramethylguanidine, and Acetylene Dicarboxylates
Authors: Yavari Issa , Sheikhi Azam , Nematpour Manijeh , Taheri Zohreh 
Published: April 2015

AbstractRegioselective synthesis of pentasubstituted pyridines has been developed in moderate‐to‐good yields by the reaction of sulfonyl azides, alkynes, and a dialkyl acetylenedicarboxylatetetramethylguanidine adduct catalyzed by CuI in MeCN at room temperature.
New Approach to Determine the Activation and Reaction Volumes of Low Polar Molecular Processes
Authors: Kornilov Dmitry A. , Kiselev Vladimir D. 
Published: April 2015

ABSTRACTFor low polar molecular processes, we found the reliable relationship between the logarithm changes of the rate or equilibrium constants in the pressure range 1–1000 bar, [Ln(KP = 1000/KP = 1)/1000], and tangent modulus at P = 1 bar, ∂Ln(KP)/∂P: ∂Ln(KP)/∂P = 1.15·[Ln(KP = 1000/KP = 1)/1000], R = 0.995, which allows to predict the value of activation and reaction volume at ambient pressure. Therefore, it is sufficient to determine the values of the rate or equilibrium constants only at ambient pressures and at 1000 bar for the reliable estimation of the values of activation or reaction volume.
Pallidal activity in myoclonus dystonia correlates with motor signs
Authors: Welter Marie‐Laure , Grabli David , Karachi Carine , Jodoin Nicolas , Fernandez‐Vidal Sara , Brun Yohann , Navarro Soledad , Rogers Alister , Cornu Philippe , Pidoux Bernard , Yelnik Jérôme , Roze Emmanuel , Bardinet Eric , Vidailhet Marie 
Published: April 2015

AbstractBackgroundMyoclonus–dystonia related to epsilon‐sarcoglycan gene mutations is characterized by myoclonic jerks and mild to moderate dystonia. The role of basal ganglia dysfunction in the pathogenesis is unknown.MethodsPallidal neuronal activity was recorded in six myoclonus–dystonia and six primary generalized dystonia patients operated on for internal globus pallidus deep brain stimulation.ResultsIn myoclonus–dystonia patients compared with primary‐dystonia patients, internal pallidum neurons showed higher burst frequency, lower mean burst, and pause durations. External pallidum neurons showed higher mean pause frequency. Oscillatory activity was present in 33% and 35% of internal pallidum neurons in myoclonus–dystonia and primary‐dystonia patients, respectively, predominantly in the theta frequency band (3‐8 Hz). In myoclonus–dystonia patients with more severe myoclonus, internal pallidum neurons exhibited a higher bursting activity with high intraburst frequency and lower oscillatory activity frequency.ConclusionsMyoclonus–dystonia appears to be related to specific changes in internal pallidum activity, leading to disruption in striato‐pallido‐thalamo‐cortical circuits. © 2015 International Parkinson and Movement Disorder Society
Extracorporeal photopheresis performed on the CELLEX® compared with the UVAR‐XTS® instrument is more efficient and better tolerated in children with steroid‐refractory graft‐versus‐host disease
Authors: Kapadia Ekta , Wong Edward , Perez‐Albuerne Evelio , Jacobsohn David 
Published: April 2015

AbstractExtracorporeal photopheresis (ECP) is an effective therapy in children with refractory graft‐versus‐host disease (GVHD). The two most frequently used instruments are UVAR‐XTS® and CELLEX®. We performed a retrospective chart review of ten patients who underwent ECP with both UVAR‐XTS® and CELLEX® instruments for steroid‐refractory acute or chronic GVHD to compare instrument run times, percentages of cells treated, and complication rates. We found that compared to the UVAR‐XTS® instrument, use of the CELLEX® instrument resulted in shorter run times, increased percentage of mononuclear cells treated, reduced incidence of line occlusions requiring TPA treatment, and decreased incidence of patient‐related complications. Pediatr Blood Cancer 2015;62:1485–1488. © 2015 Wiley Periodicals, Inc.
Online estimation of laser incision depth for transoral microsurgery: approach and preliminary evaluation
Authors: Fichera Loris , Pardo Diego , Illiano Placido , Ortiz Jesùs , Caldwell Darwin G. , Mattos Leonardo S. 
Published: April 2015

AbstractBackgroundThe use of lasers in transoral surgery enables precise tissue incision with minimal adverse effects on surrounding structures. Nonetheless, the lack of haptic feedback during laser cutting impairs the surgeon's perception of the incision depth, potentially leading to undesired tissue damage.MethodsThis paper presents a novel approach, based on statistical regression analysis, to estimate the laser incision depth in soft tissue. User trials were conducted in a laser surgery set‐up, to verify the effectiveness of online estimation of incision depth in supporting precise tissue cutting.ResultsThe estimation accuracy was verified on ex vivo muscle tissue, revealing a root mean squared error (RMSE) of 0.1 mm for depths ranging up to 1.4 mm. Online estimation of depth has the potential to significantly improve the incision control of users.ConclusionsThe proposed approach was successful in producing estimations of laser cutting depth in ex vivo muscle tissue. Further investigation is required to validate this approach on other types of tissue. Providing depth estimation during laser cutting allows users to perform more precise incisions. Copyright © 2015 John Wiley & Sons, Ltd.
HIV Testing Experience and Risk Behavior Among Sexually Active Black Young Adults: A CBPR‐Based Study Using Respondent‐Driven Sampling in Durham, North Carolina
Authors: MacQueen Kathleen M. , Chen Mario , Jolly David , Mueller Monique P. , Okumu Eunice , Eley Natalie T. , Laws Michelle , Isler Malika Roman , Kalloo Allison , Rogers Randy C. 
Published: April 2015

AbstractAfrican Americans are disproportionately affected by the HIV epidemic inclusive of men who have sex with men, heterosexual men, and women. As part of a community‐based participatory research study we assessed HIV testing experience among sexually active 18–30 year old Black men and women in Durham, NC. Of 508 participants, 173 (74 %) men and 236 (86 %; p = 0.0008) women reported ever being tested. Barriers to testing (e.g., perceived risk and stigma) were the same for men and women, but men fell behind mainly because a primary facilitator of testing—routine screening in clinical settings—was more effective at reaching women. Structural and behavioral risk factors associated with HIV infection were prevalent but did not predict HIV testing experience. Reduced access to health care services for low income Black young adults may exacerbate HIV testing barriers that already exist for men and undermine previous success rates in reaching women.
Simpliciores,Eruditi, and the Noetic Form of God: Pre-Nicene Christology Revisited
Authors: Giulea Dragoş Andrei 
Published: April 2015

Carl W. Griffin and David L. Paulsen have shown that anthropomorphism, one of the most popular and equally biblical tenets of ancient Christianity, was spread out not only among thesimpliciores(the simple) of the early ecclesia but also among itseruditi(its educated members), particularly suchdocti(learned) in Stoicism like Tertullian. Following previous researchers, Griffin and Paulsen have also argued that Christian Platonizing authors, starting with Origen in the East and Marius Victorinus in the West, developed a sturdy campaign of promoting the doctrine of an incorporeal God. At a time when the clergy itself was largely conceiving God as a corporeal entity, the Christian Platonists were heavily employing the rhetoric of erudition in order to uphold an anti-anthropomorphist agenda. Other scholars have noticed that Origen of Alexandria was the first (or among the first) to relate the anthropomorphist position to the uneducated members of the Christian community, thesimpliciores. Later on, Cassian, Socrates, Sozomen, and Palladius will communicate the events of the Origenist debate by means of the same distinction betweensimplicioresanderuditi. As Elizabeth A. Clark observes:According to several fifth-century Christian writers—Socrates, Sozomen, and Palladius, all of whom sided with the alleged Origenists—the simple desert Monks were outraged by Theophilus of Alexandria's Festal Letter of 399 that championed God's incorporeality, a position in accord with that of Alexandria's most important theologian, Origen.Griffin and Paulsen equally find several Augustinian pages in which the bishop of Hippo asserts that the “Church'seducated men(docti)” cannot embrace anthropomorphism, and he prefers to portray the less educated Christians as “whimpering babies,” “children,” or possessing a “childishness of mind.”
Older people's exercising of choice in long-term care: a comparative analysis of England and Japan
Authors: WADA YOSHIMI 
Published: April 2015

ABSTRACTThere has been an increasing emphasis on choice for older people in long-term care in both England and Japan. However, despite the emphasis on the importance of choice, the perspectives of older people have been given little attention. Considering national and local policies in Bristol, England and Kyoto, Japan, the article explores how older people are exercising (and not exercising) choice in care practice through examining the perspectives of the older people themselves, as well as key informants in the field. Empirical data were collected from interviews with older people and key informants in the two countries, and were analysed using qualitative and comparative approaches. Choice in policy is regarded as a mechanism of the market with an assumption of the independent autonomous individual who can exercise ‘rational choice’. However, the findings have reflected older people's relational decision-making, which does not conform to the rational model of decision-making, and illustrates the value of ‘interdependence’. The findings from care practice have shown that choice was considered an important value in involving older people's views and ensuring their needs are met sensitively and respectfully. The findings also suggested that consideration of the psychological aspects of choice is an important aspect of ‘care’, facilitating the inclusion of older people's views in the process of making judgements, in order to meet their needs.
A nonlinear trajectory tracking controller for mobile robots with velocity limitation via parameters regulation
Authors: Serrano Mario E. , Godoy Sebastián A. , Mut Vicente A. , Ortiz Oscar A. , Scaglia Gustavo J. E. 
Published: April 2015

SUMMARYThis paper addresses the problem of trajectory tracking control in mobile robots under velocity limitations. Following the results reported in ref. [1], the problem of trajectory tracking considering control actions constraint is focused and the zero convergence of the tracking errors is demonstrated. In this work, the original methodology is expanded considering a controller that depends not only on the position but also on the velocity. A simple scheme is obtained, which can be easily implemented in others controllers of the literature. Experimental results are presented and discussed, demonstrating the good performance of the controller.
One-stage surgical treatment for Cantrell syndrome without repairing the left ventricular diverticulum: a case report
Authors: Yang Yang , Jiang Zhaolei , Ding Fangbao 
Published: April 2015

AbstractCantrell syndrome includes the defects of the heart, pericardium, diaphragm, abdominal wall, and sternum. The operative mortality is usually high. We report here a one-stage surgical correction in a case of Cantrell syndrome with left ventricular diverticulum.
Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury
Authors: Noro T , Namekata K , Kimura A , Guo X , Azuchi Y , Harada C , Nakano T , Tsuneoka H , Harada T 
Published: April 2015

AbstractSpermidine acts as an endogenous free radical scavenger and inhibits the action of reactive oxygen species. In this study, we examined the effects of spermidine on retinal ganglion cell (RGC) death in a mouse model of optic nerve injury (ONI). Daily ingestion of spermidine reduced RGC death following ONI and sequential in vivo retinal imaging revealed that spermidine effectively prevented retinal degeneration. Apoptosis signal-regulating kinase-1 (ASK1) is an evolutionarily conserved mitogen-activated protein kinase kinase kinase and has an important role in ONI-induced RGC apoptosis. We demonstrated that spermidine suppresses ONI-induced activation of the ASK1-p38 mitogen-activated protein kinase pathway. Moreover, production of chemokines important for microglia recruitment was decreased with spermidine treatment and, consequently, accumulation of retinal microglia is reduced. In addition, the ONI-induced expression of inducible nitric oxide synthase in the retina was inhibited with spermidine treatment, particularly in microglia. Furthermore, daily spermidine intake enhanced optic nerve regeneration in vivo. Our findings indicate that spermidine stimulates neuroprotection as well as neuroregeneration, and may be useful for treatment of various neurodegenerative diseases including glaucoma.
The metallome of the human placenta in gestational diabetes mellitus
Authors: Roverso Marco , Berté Chiara , Marco Valerio Di , Lapolla Annunziata , Badocco Denis , Pastore Paolo , Visentin Silvia , Cosmi Erich 
Published: April 2015

Abstract
Obtaining the knowledge of the “omics” and therefore of the metallomics of gestational diabetes mellitus (GDM) appears to be a necessary task to obtain information about the molecular causes of this disease. In this study, the metallome of GDM and of other types of diabetes mellitus was first reviewed. The comparative analysis of the published data revealed that no GDM elemental markers could be identified with sufficient reliability in blood or in the other considered samples, with the partial exception of selenium. The placenta was chosen as an alternative target organ for the analysis of the GDM metallome. The full elemental average composition of 19 healthy placentas was obtained by ICP-MS. Analyses were then performed on 28 placentas from women affected by GDM. The statistical tests and the principal component analysis evidenced that cadmium was found in lower concentrations and selenium was found in higher concentrations in GDM placentas than in those of the control group. These results were interpreted in light of literature data, and they attract attention on two key elements for understanding the molecular pathways of GDM.