bluuebunny/crossref_metadata_2025_split huggingface dataset:
DUSP1 Phosphatase Regulates the Proinflammatory Milieu in Head and Neck Squamous Cell Carcinoma
Authors: Zhang Xiaoyi , Hyer J. Madison , Yu Hong , D'Silva Nisha J. , Kirkwood Keith L. 
Published: October 2014

Abstract
DUSP1 is a dual-specificity phosphatase that regulates mitogen-activated protein (MAP) kinase activity. Studies have associated loss of DUSP1 expression with certain cancers, but there has been no report of a mechanism by which this supports tumor progression. In this study, we found DUSP1 mRNA and protein decreased in human head and neck squamous cell carcinoma tissues compared with adjacent nontumor controls. To evaluate the impact of this difference, we compared the susceptibility of Dusp1-deficient mice with oral squamous carcinogenesis induced by 4-nitroquinoline 1-oxide. Dusp1-deficient mice displayed enhanced disease progression, characterized by advanced onset, histologic stage, and tumor burden. In a syngeneic model of tumor progression, subcutaneous injection of EO771 cells formed faster-growing tumors in Dusp1-deficient mice, an effect abrogated by inhibition of p38 MAP kinase with SB203580. Histologic and quantitative assessments demonstrated increased inflammation and deregulated chemokine and cytokine expression in Dusp1-deficient tumor tissues. Specifically, proinflammatory cytokine IL1β was elevated. IL1β production was recapitulated ex vivo in primary bone marrow–derived macrophages from Dusp1-deficient mice. Together, our results clearly establish the role of Dusp1 as a tumor suppressor gene that regulates cancer-associated inflammation. Cancer Res; 74(24); 7191–7. ©2014 AACR.
NT113, a Pan-ERBB Inhibitor with High Brain Penetrance, Inhibits the Growth of Glioblastoma Xenografts with EGFR Amplification
Authors: Yoshida Yasuyuki , Ozawa Tomoko , Yao Tsun-Wen , Shen Wang , Brown Dennis , Parsa Andrew T. , Raizer Jeffrey J. , Cheng Shi-Yuan , Stegh Alexander H. , Mazar Andrew P. , Giles Francis J. , Sarkaria Jann N. , Butowski Nicholas , Nicolaides Theodore , James C. David 
Published: October 2014

Abstract
This report describes results from our analysis of the activity and biodistribution of a novel pan-ERBB inhibitor, NT113, when used in treating mice with intracranial glioblastoma (GBM) xenografts. Approaches used in this investigation include: bioluminescence imaging (BLI) for monitoring intracranial tumor growth and response to therapy; determination of survival benefit from treatment; analysis of tumor IHC reactivity for indication of treatment effect on proliferation and apoptotic response; Western blot analysis for determination of effects of treatment on ERBB and ERBB signaling mediator activation; and high-performance liquid chromatography for determination of NT113 concentration in tissue extracts from animals receiving oral administration of inhibitor. Our results show that NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. In experiments including lapatinib and/or erlotinib, NT113 treatment was associated with the most substantial improvement in survival, as well as the most substantial tumor growth inhibition, as indicated by BLI and IHC results. Western blot analysis results indicated that NT113 has inhibitory activity, both in vivo and in vitro, on ERBB family member phosphorylation, as well as on the phosphorylation of downstream signaling mediator Akt. Results from the analysis of animal tissues revealed significantly higher NT113 normal brain-to-plasma and intracranial tumor-to-plasma ratios for NT113, relative to erlotinib, indicating superior NT113 partitioning to intracranial tissue compartments. These data provide a strong rationale for the clinical investigation of NT113, a novel ERBB inhibitor, in treating patients with GBM. Mol Cancer Ther; 13(12); 2919–29. ©2014 AACR.
Reinstatement of Individual Past Events Revealed by the Similarity of Distributed Activation Patterns during Encoding and Retrieval
Authors: Wing Erik A. , Ritchey Maureen , Cabeza Roberto 
Published: October 2014

Abstract
Neurobiological memory models assume memory traces are stored in neocortex, with pointers in the hippocampus, and are then reactivated during retrieval, yielding the experience of remembering. Whereas most prior neuroimaging studies on reactivation have focused on the reactivation of sets or categories of items, the current study sought to identify cortical patterns pertaining to memory for individual scenes. During encoding, participants viewed pictures of scenes paired with matching labels (e.g., “barn,” “tunnel”), and, during retrieval, they recalled the scenes in response to the labels and rated the quality of their visual memories. Using representational similarity analyses, we interrogated the similarity between activation patterns during encoding and retrieval both at the item level (individual scenes) and the set level (all scenes). The study yielded four main findings. First, in occipitotemporal cortex, memory success increased with encoding-retrieval similarity (ERS) at the item level but not at the set level, indicating the reactivation of individual scenes. Second, in ventrolateral pFC, memory increased with ERS for both item and set levels, indicating the recapitulation of memory processes that benefit encoding and retrieval of all scenes. Third, in retrosplenial/posterior cingulate cortex, ERS was sensitive to individual scene information irrespective of memory success, suggesting automatic activation of scene contexts. Finally, consistent with neurobiological models, hippocampal activity during encoding predicted the subsequent reactivation of individual items. These findings show the promise of studying memory with greater specificity by isolating individual mnemonic representations and determining their relationship to factors like the detail with which past events are remembered.
Regional White Matter Variation Associated with Domain-specific Metacognitive Accuracy
Authors: Baird Benjamin , Cieslak Matthew , Smallwood Jonathan , Grafton Scott T. , Schooler Jonathan W. 
Published: October 2014

AbstractThe neural mechanisms that mediate metacognitive ability (the capacity to accurately reflect on one's own cognition and experience) remain poorly understood. An important question is whether metacognitive capacity is a domain-general skill supported by a core neuroanatomical substrate or whether regionally specific neural structures underlie accurate reflection in different cognitive domains. Providing preliminary support for the latter possibility, recent findings have shown that individual differences in metacognitive ability in the domains of memory and perception are related to variation in distinct gray matter volume and resting-state functional connectivity. The current investigation sought to build on these findings by evaluating how metacognitive ability in these domains is related to variation in white matter microstructure. We quantified metacognitive ability across memory and perception domains and used diffusion spectrum imaging to examine the relation between high-resolution measurements of white matter microstructure and individual differences in metacognitive accuracy in each domain. We found that metacognitive accuracy for perceptual decisions and memory were uncorrelated across individuals and that metacognitive accuracy in each domain was related to variation in white matter microstructure in distinct brain areas. Metacognitive accuracy for perceptual decisions was associated with increased diffusion anisotropy in white matter underlying the ACC, whereas metacognitive accuracy for memory retrieval was associated with increased diffusion anisotropy in the white matter extending into the inferior parietal lobule. Together, these results extend previous findings linking metacognitive ability in the domains of perception and memory to variation in distinct brain structures and connections.
Functional Properties of Parietal Hand Manipulation–related Neurons and Mirror Neurons Responding to Vision of Own Hand Action
Authors: Maeda Kazutaka , Ishida Hiroaki , Nakajima Katsumi , Inase Masahiko , Murata Akira 
Published: October 2014

Abstract
Parietofrontal pathways play an important role in visually guided motor control. In this pathway, hand manipulation-related neurons in the inferior parietal lobule represent 3-D properties of an object and motor patterns to grasp it. Furthermore, mirror neurons show visual responses that are concerned with the actions of others and motor-related activity during execution of the same grasping action. Because both of these categories of neurons integrate visual and motor signals, these neurons may play a role in motor control based on visual feedback signals. The aim of this study was to investigate whether these neurons in inferior parietal lobule including the anterior intraparietal area and PFG of macaques represent visual images of the monkey's own hand during a self-generated grasping action. We recorded 235 neurons related to hand manipulation tasks. Of these, 54 responded to video clips of the monkey's own hand action, the same as visual feedback during that action or clips of the experimenter's hand action in a lateral view. Of these 54 neurons, 25 responded to video clips of the monkey's own hand, even without an image of the target object. We designated these 25 neurons as “hand-type.” Thirty-three of 54 neurons that were defined as mirror neurons showed visual responses to the experimenter's action and motor responses. Thirteen of these mirror neurons were classified as hand-type. These results suggest that activity of hand manipulation-related and mirror neurons in anterior intraparietal/PFG plays a fundamental role in monitoring one's own body state based on visual feedback.
C. Licinius Mucianus, Vespasian’s Co-ruler in Rome
Authors: Kleijn Gerda de 
Published: October 2014

AbstractLeadership in Rome after the Flavian victory in the civil war of AD 68-9 is based on an agreement made by Vespasian, Titus, and C. Licinius Mucianus. Tacitus presents the latter in hisHistoriaeas the person in charge in the western part of the empire. This article centers on the way in which Tacitus shows Mucianus’ leadership facing different serious challenges. It turns out that Mucianus is able to meet all threats to stability by appropriate measures. In Tacitus’ account, Mucianus shows excellent situational leadership.
Historical Epistemology and Pentecostal Origins: History and Historiography in Ethiopian Pentecostalism
Authors: Haustein Jörg 
Published: October 2014

Abstract
This article revisits the issue of historiography in Pentecostal studies, seeking to connect this debate to recent theories of history coming from postcolonial and poststructuralist thought. I argue that the historian of Pentecostalism should seek not only to reconstruct past events, but, more than that, to offer a historical analysis of Pentecostal historiography. By drawing on four related theoretical insights into history and applying them to a concrete example from Ethiopian Pentecostalism, I aim to contribute to the epistemological reflection of Pentecostal historiography.
Liturgical Prayer of the Faithful: A Theological Adaptation from a Pentecostal Perspective
Authors: Ukpong Donatus Pius 
Published: October 2014

Abstract
The eucharistic celebration is the highest prayer of the church, where through Christ, with Christ, in Christ, in the unity of the Holy Spirit, all glory and honor is given to God. In this article I examine the modus of the prayer of the faithful at the Roman Catholic eucharistic celebration in Nigeria. Are individuals free to express themselves in worship? I study the church’s worship and prayer and offer proposals from the perspective of modern Pentecostalism, which, according to recent surveys and research, is seriously influencing Catholicism in many African countries. Furthermore, I articulate a model of adaptation that respects the church’s liturgy and, at the same time, permits the faithful to experience their freedom and the power of the Holy Spirit during liturgical celebrations. Finally, I contend that both intellectualism and emotionalism are valid dimensions of being human and, therefore, are pleasing and acceptable to God in the liturgy.
Reputation by Committee? Finland’s Committee for International Information, 1988-1990
Authors: Clerc Louis 
Published: October 2014

Summary
In October 1988, an ordinance of the Finnish government created the Committee for International Information (Kansainvälisen tiedottamisen neuvottelukunta, or Kantine). Kantine came as the last of a series of Cold War efforts to centrally define an image of Finland fit for foreign consumption, and to establish the communication methods through which state authorities and their partners could use this image as an economic and political asset. Established under the coordination of the Finnish Ministry of Foreign Affairs, Kantine acts as a window into the evolution of Finnish national image management and its state at the end of the Cold War. However, the context of the late 1980s and the desire of Kantine’s members to use the committee as the platform for a ‘wide societal debate on Finland in the twenty-first century’ gave it a broader scope than other ‘national image committees’ that had preceded it since 1945. This article will place Kantine in the evolution of Finland’s national image management and image policy, and will summarize its work and consequences.
Rock art as a source of the history of prehistory (An account to promote the understanding of prehistoric rock art)
Authors: Abd-EI-Moniem Hamdi Abbas Ahmed 
Published: October 2014

Abstract
Some may believe that the history of mankind begins with the appearance of writing only a few several thousands of years ago (cf. 4000-3000 BCE). Our history, however, extends beyond that date millions of years. The history of mankind, indeed, is deeply rooted in the remote past which is called 'prehistory'. With the lacking of any form of writing, this 'prehistoric' period can be examined directly solely by recourse to the study of archaeological remains. The purpose of this account is to introduce rock art to the readers and show the significant role of this sort of archaeological material in studying the history of mankind before the appearance of written records. The current work, therefore, is divided into three main sections: the first deals with definition of rock art and its nature; the second section is devoted to showing the significance of this aspect of material culture in exploring a long and mysterious period of the early history of man characterized by the complete absence of written records or historical documents; the third and last section, which is a vital and integral part of this work, comprises an explanatory pictorial record to promote the understanding of prehistoric rock art as a source of information needed for writing the history of prehistory.
A New Dew and Frost Detection Sensor Based on Computer Vision
Authors: Zhu Lei , Cao Zhiguo , Zhuo Wen , Yan Ruicheng , Ma Shuqing 
Published: October 2014

AbstractMany weather features such as precipitation and snow depth can be recorded using automatic surface observation systems. However, automatically observing dew and frost presents several problems. Many studies have used various wetness sensors and passive microwave devices to detect dew. Unfortunately, several of these sensors are complex, and only a few are capable of detecting frost. This paper proposes a novel method for indirectly detecting dew and frost based on computer vision. The setup is simple, inexpensive, and only requires images of several glass substrates near the underlying surface. Images taken during dew or frost formation exhibit distinct changes in hierarchical visual features. These changes are detected by tracking the variations of several low-level statistical features that are extracted from the images in time. Additionally, an effective texture analysis method is proposed to describe the morphology of frost. Field experiments were conducted at several weather stations in Beijing, China. The validation of the method for measuring the onset and duration of dew/frost on short grass shows that 1) the proposed computer-vision-based algorithm achieves an accuracy of approximately 90% in discriminating among dewy, frosty, and dry nights based on the hourly manual observations of the grass surface and 2) the algorithm is also capable of measuring the duration of dew and frost on grass with about 70% accuracy.
Endovenous laser ablation in patients with wide diameter of the proximal segment of the great saphenous vein: Comparison of methods
Authors: Starodubtsev V , Lukyanenko M , Karpenko A , Ignatenko P 
Published: October 2014

Objective To estimate the safety and efficacy of using the laser 1560 nm wavelength for treatment of chronic venous disease in patients with wide diameters of the proximal segment of the great saphenous vein. Methods In the study 88 patients with lower limb varicose veins were included. Maximum diameter of the great saphenous vein proximal segment varied from 15 to 34 mm (22 ± 2.3) in all patients. In the 1st group in 34 cases crossektomy and endovenous laser ablation (EVLA) were performed. In the 2nd group in 30 cases EVLA regardless diameter of the great saphenous vein proximal segment was performed. In the 3rd group in 34 cases EVLA taking into account the diameter of the great saphenous vein proximal segment was performed. The laser 1560 nm wavelength was used. Linear endovenous energy density in the 1st and 2nd groups was 90 J/cm for the proximal segment and trunk of great saphenous vein. Linear endovenous energy density in the 3rd group was personalized on the size of the veins: 100 J/cm for diameter of great saphenous vein proximal segment 15–20 mm, 150 J/cm for diameter 20–30 mm, 90 J/cm for middle and distal segments of great saphenous vein. Results In the 1st group obliteration of the trunk of the great saphenous veins and accessory great saphenous veins in all cases without additional interventions was reached. In the 2nd group at four cases (13.3%) the second procedure EVLA was carried out, after which the obliteration of the trunk was achieved. In the 3rd group the obliteration of the trunk of great saphenous vein was achieved without additional interventions. Conclusion Our experience of using the laser 1560 nm wavelength for the treatment of the chronic venous disease in patients with wide diameter of the proximal segment of great saphenous vein shows the safety and efficacy of this technique. EVLA has to be personalized on the size of the segments of vein in patients with wide proximal segment of great saphenous vein.
Energy-efficient uplink power control for multiuser SIMO systems with imperfect channel state information
Authors: Jang Moonheok , Kwon Younggap , Park Hyunsung , Hwang Taewon 
Published: October 2014

Abstract
This paper addresses energy-efficient design for uplink multiuser SIMO systems with imperfect channel state information (CSI) at the base station (BS). Since the CSI at the BS is always imperfect due to the channel estimation error and delay, the imperfectness of the CSI needs to be considered in practical system design. It causes interuser interference at the zero-forcing (ZF) receiver and makes it difficult to obtain the globally optimal power allocation that maximizes the energy efficiency (EE). Hence, we propose a non-cooperative energy-efficient uplink power control game, where each user selfishly updates its own uplink power. The proposed uplink power control game is shown to admit a unique Nash equilibrium. Furthermore, to improve the efficiency of the Nash equilibrium, we study a new game that utilizes a pricing mechanism. For the new game, the existence of a Nash equilibrium and the convergence of the best response dynamics are studied based on super-modularity theory. Simulation results show that the proposed schemes can significantly improve the EEs of the mobile users in uplink multiuser SIMO systems.
Is puberty a risk factor for back pain in the young? a systematic critical literature review
Authors: Lardon Arnaud , Leboeuf-Yde Charlotte , Le Scanff Christine , Wedderkopp Niels 
Published: October 2014

Abstract
Background
Back pain is a common condition that starts early in life and seems to increase markedly during puberty. A systematic review was performed in order to investigate the link between puberty and back pain, using some Bradford Hill criteria for causality.

Objectives
We sought to obtain answers to the following questions: 1) Is there an association between puberty and back pain? If so, how strong is this association? And do the results remain unchanged also when controlling for age and sex? 2) Are the results of the studies consistent? 3) Is there a dose-response, showing a link between the increasing stages of puberty and the subsequent prevalence of back pain? 4) Is there a temporal link between puberty and back pain?

Design
A systematic critical literature review.

Methods
Systematic searches were made in March 2014 in PubMed, Embase, CINAHL and PsycINFO including longitudinal or cross-sectional studies on back pain for subjects <19 years, written in French or English. The review process followed the AMSTAR recommendations. Interpretation was made using some of the Bradford-Hill criteria for causality.

Results
Four articles reporting five studies were included, two of which were longitudinal. 1) Some studies show a weak and others a strong positive association between puberty and back pain, which remains after controlling for age and sex; 2) Results were consistent across the studies; 3) There was a linear increase of back pain according to the stage of puberty 4) Temporality has not been sufficiently studied.

Conclusion
All our criteria for causality were fulfilled or somewhat fulfilled indicating the possibility of a causal link between puberty and back pain. Future research should focus on specific hypotheses, for example investigating if there could be a hormonal or a biomechanical aspect to the development of back pain at this time of life.
Spectroscopic and Molecular Dynamics Studies on Binding of Dimethylplatinum(II) Complex Drug to Human Serum Albumin
Authors: Yousefi Reza , Alavianmehr Mohammad Mehdi , Mokhtari Fatemeh , Keshavarz Fatemeh , Nabavizadeh Seyed Masoud , Rashidi Mehdi , Moosavi-Movahedi Ali Akbar 
Published: October 2014

Abstract
In the present work, the interaction of a dimethylplatinum(II) complex (Pt(II) complex) with DNA and human serum albumin (HSA) was studied by different spectroscopic techniques, including UV–vis spectroscopy, fluorescence, and far-UV circular dichroism (CD). The Pt(II) complex exhibits strong ability in quenching the intrinsic fluorescence of HSA. The results of far-UV CD suggest that this Pt(II) complex induces significant reduction of HSA α-helical structure which was accompanied with the elevation in quantity of the other protein structures. Molecular simulation and fluorescence spectroscopic results were employed to define the van der Waals and hydrophobic interactions of this complex with HSA. Also, the half maximal cytotoxic concentration (Cc50) of the complex was found to be 17.33 and 3.95 µM for the incubation times of 24 and 48 h, respectively. The results show that this complex is a promising antiproliferative agent that can serve as a new drug with anticancer properties.
Photoisomerization and Single Bond Rotation in trans-1,2-Di(2-naphthyl)ethene-Cored Dendrimers
Authors: Nakazato Satoshi , Arai Tatsuo 
Published: October 2014

Abstract
A trans-1,2-di(2-naphthyl)ethane-cored dendrimer formed molecular assemblies in aqueous KOH solution exhibiting excimer fluorescence that disappeared upon photoirradiation.