bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proceedings of the Indo‐U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival
Authors: B. Kumar Nagi , Dhurandhar Medha , Aggarwal Bharat , Anant Shrikant , Daniel Kenyon , Deng Gary , Djeu Julie , Dou Jinhui , Hawk Ernest , Jayaram B. , Jia Libin , Joshi Rajendra , Kararala Madhuri , Karunagaran Devarajan , Kucuk Omer , Kumar Lalit , Malafa Mokenge , Samathanam G. J. , Sarkar Fazlul , Siddiqi Maqsood , Singh Rana P. , Srivastava Anil , White Jeffrey D. 
Published: November 2012

AbstractWith the evolving evidence of the promise of botanicals/biologics for cancer chemoprevention and treatment, an Indo‐U.S. collaborative Workshop focusing on “Accelerating Botanicals Agent Development Research for Cancer Chemoprevention and Treatment” was conducted at the Moffitt Cancer Center, 29–31 May 2012. Funded by the Indo‐U.S. Science and Technology Forum, a joint initiative of Governments of India and the United States of America and the Moffitt Cancer Center, the overall goals of this workshop were to enhance the knowledge (agents, molecular targets, biomarkers, approaches, target populations, regulatory standards, priorities, resources) of a multinational, multidisciplinary team of researcher's to systematically accelerate the design, to conduct a successful clinical trials to evaluate botanicals/biologics for cancer chemoprevention and treatment, and to achieve efficient translation of these discoveries into the standards for clinical practice that will ultimately impact cancer morbidity and mortality. Expert panelists were drawn from a diverse group of stakeholders, representing the leadership from the National Cancer Institute's Office of Cancer Complementary and Alternative Medicine (OCCAM), NCI Experimental Therapeutics (NExT), Food and Drug Administration, national scientific leadership from India, and a distinguished group of population, basic and clinical scientists from the two countries, including leaders in bioinformatics, social sciences, and biostatisticians. At the end of the workshop, we established four Indo‐U.S. working research collaborative teams focused on identifying and prioritizing agents targeting four cancers that are of priority to both countries. Presented are some of the key proceedings and future goals discussed in the proceedings of this workshop.
Comparison of the results of transcatheter closure of patent ductus arteriosus with newer amplatzer devices
Authors: Liddy Stephen , Oslizlok Paul , Walsh Kevin P. 
Published: November 2012

ObjectivesTo compare the success and complication rates for the different devices and patent ductus arteriosus (PDA) types.BackgroundThere are numerous devices available for transcatheter closure of PDA but data comparing the success and complication rates of the newer devices are lacking.MethodsA retrospective review was undertaken of all cases of transcatheter PDA closure at a tertiary referral center.ResultsTranscatheter PDA closure was achieved in 176 of 177 cases. Mean age, weight, and minimum ductal diameter were 3.3 years, 15.0 kg, and 2.5 mm, respectively. Devices used were Amplatzer Duct Occluder I (ADO I, 50.3%), Amplatzer Duct Occluder II (ADO II, 28.2%), Amplatzer Duct Occluder II Additional Sizes (ADO II AS, 5.1%), flipper coils (14.1%), and “other” devices (2.3%). Regarding Amplatzer devices, arterial delivery had a significantly shorter fluoroscopy time as compared to venous delivery (3.7 vs. 5.0 min, P = 0.0068), with no significant difference in outcomes. Immediate residual shunt rates were 7.9% (7/89) for ADO I, 4.1% (2/49) for ADO II, 11.1% (1/9) for ADO II AS, and 0% (0/25) for flipper coils. Aortic protrusion rates were 9% (8/89) for ADO I, 14.3% (7/49) for ADO II, and O% for both ADO II AS (0/9) and flipper coils (0/25).ConclusionsAll devices achieved excellent occlusion rates with low complication rates, regardless of PDA type. Device delivery via arterial access was associated with a shorter fluoroscopy time as compared to venous delivery, with no significant difference in outcomes. ADO II AS may be preferable to ADO II in the younger infant. © 2013 Wiley Periodicals, Inc.
Efficient Access to Peptidyl‐RNA Conjugates for Picomolar Inhibition of Non‐ribosomal FemXWv Aminoacyl Transferase
Authors: Fonvielle Matthieu , Mellal Dénia , Patin Delphine , Lecerf Maxime , Blanot Didier , Bouhss Ahmed , Santarem Marco , Mengin‐Lecreulx Dominique , Sollogoub Matthieu , Arthur Michel , Ethève‐Quelquejeu Mélanie 
Published: November 2012

AbstractPeptidyl–RNA conjugates have various applications in studying the ribosome and enzymes participating in tRNA‐dependent pathways such as Fem transferases in peptidoglycan synthesis. Herein a convergent synthesis of peptidyl–RNAs based on Huisgen–Sharpless cycloaddition for the final ligation step is developed. Azides and alkynes are introduced into tRNA and UDP‐MurNAc‐pentapeptide, respectively. Synthesis of 2′‐azido RNA helix starts from 2′‐azido‐2′‐deoxyadenosine that is coupled to deoxycytidine by phosphoramidite chemistry. The resulting dinucleotide is deprotected and ligated to a 22‐nt RNA helix mimicking the acceptor arm of Ala‐tRNAAla by T4 RNA ligase. For alkyne UDP‐MurNAc‐pentapeptide, meso‐cystine is enzymatically incorporated into the peptidoglycan precursor and reduced, and L‐Cys is converted to dehydroalanine with O‐(mesitylenesulfonyl)hydroxylamine. Reaction of but‐3‐yne‐1‐thiol with dehydroalanine affords the alkyne‐containing UDP‐MurNAc‐pentapeptide. The CuI‐catalyzed azide alkyne cycloaddition reaction in the presence of tris[(1‐hydroxypropyl‐1H‐1,2,3‐triazol‐4‐yl)methyl]amine provided the peptidyl‐RNA conjugate, which was tested as an inhibitor of non‐ribosomal FemXWv aminoacyl transferase. The bi‐substrate analogue was found to inhibit FemXWv with an IC50 of (89±9) pM, as both moieties of the peptidyl–RNA conjugate contribute to high‐affinity binding.
Influence of Peripheral Substitution on the Magnetic Behavior of Single‐Ion Magnets Based on Homo‐ and Heteroleptic TbIII Bis(phthalocyaninate)
Authors: Ganivet Carolina R. , Ballesteros Beatriz , de la Torre Gema , Clemente‐Juan Juan M. , Coronado Eugenio , Torres Tomás 
Published: November 2012

AbstractA series of homoleptic ([TbIII(Pc)2]) and heteroleptic ([TbIII(Pc)(Pc′)]) TbIII bis(phthalocyaninate) complexes that contain different peripheral substitution patterns (i.e., tert‐butyl or tert‐butylphenoxy groups) have been synthesized in their neutral radical forms and then reduced into their corresponding anionic forms as stable tetramethylammonium/tetrabutylammonium salts. All of these compounds were spectroscopically characterized and their magnetic susceptibility properties were investigated. As a general trend, the radical forms exhibited larger energy barriers for spin reversal than their corresponding reduced compounds. Remarkably, heteroleptic complexes that contain electron‐donor moieties on one of the two Pc ligands show higher effective barriers and blocking temperatures than their homoleptic derivatives. This result is assigned to the elongation of the NTb distances in the substituted macrocycle, which brings the terbium(III) ion closer to the unsubstituted Pc, thus enhancing the ligand‐field effect. In particular, heteroleptic [TbIII(Pc)(Pc′)] complex 4, which contains one octa(tert‐butylphenoxy)‐substituted Pc ring and one bare Pc ring, exhibits the highest effective barrier and blocking temperature for a single‐molecule magnet reported to date.
Discriminatory Detection of Cysteine and Homocysteine Based on Dialdehyde‐Functionalized Aggregation‐Induced Emission Fluorophores
Authors: Mei Ju , Wang Yijia , Tong Jiaqi , Wang Jian , Qin Anjun , Sun Jing Zhi , Tang Ben Zhong 
Published: November 2012

AbstractWe demonstrate a concept‐proof work of using fluorescence (FL) “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation‐induced emission (AIE) characteristic and functionalized with two aldehyde‐groups (DMTPS‐ALD and TPE‐ALD). All the detections were carried out in a biocompatible medium (10 mM HEPES buffer and DMSO, pH 7.4). In principle, the formation of thiazinane/thiazolidine through the chemical reaction of aldehydes on the probe molecules and the residue of Cys/Hcy determines the selective recognition of Cys and Hcy over other amino acids and glucose. The FL responses originate from the AIE property of thiazinane/thiazolidine resultants, which have low solubility and precipitate (aggregate) in the detection medium. The discrimination between Cys and Hcy comes from the difference in reaction kinetics of TPE‐ALD/DMTPS‐ALD with Cys and Hcy, thereby the FL responses show different time courses and intensity enhancement. It is worth noting that TPE‐ALD outshined the other two probes in performance with fast response, a high FL enhancement up to 16‐fold, high sensitivity, and good specificity and selectivity. Moreover, its FL response threshold at 250 μM is very close to the lower limit of the normal level of Cys in human plasma, which implies that TPE‐ALD could be applied as a potential indicator of Cys deficiency.
Diastereo‐ and Regioselective Addition of Thioamide Dianions to Imines and Aziridines: Synthesis of N‐Thioacyl‐1,2‐diamines and N‐Thioacyl‐1,3‐diamines
Authors: Shibahara Fumitoshi , Kobayashi Shun‐ichiro , Maruyama Toshifumi , Murai Toshiaki 
Published: November 2012

AbstractAddition reactions of thioamide dianions that were derived from N‐arylmethyl thioamides to imines and aziridines were carried out. The reactions of imines gave the addition products of N‐thioacyl‐1,2‐diamines in a highly diastereoselective manner in good‐to‐excellent yields. The diastereomeric purity of these N‐thioacyl‐1,2‐diamines could be enriched by simple recrystallization. The reduction of N‐thioacyl‐1,2‐diamines with LiAlH4 gave their corresponding 1,2‐diamines in moderate‐to‐good yields with retention of their stereochemistry. The oxidative‐desulfurization/cyclization of an N‐thioacyl‐1,2‐diamine in CuCl2/O2 and I2/pyridine systems gave the cyclized product in moderate yield and the trans isomer was obtained as the sole product. On the other hand, a similar cyclization reaction with antiformin (aq. NaClO) as an oxidant gave the cis isomer as the major product. The reactions of N‐tosylaziridines gave the addition products of N‐thioacyl‐1,3‐diamines with low diastereoselectivity but high regioselectivity and in good‐to‐excellent yields. The use of AlMe3 as an additive improved the efficiency and regioselectivity of the reaction. The stereochemistry of the obtained products was determined by X‐ray diffraction.
ChemInform Abstract: Synthesis and Characterization of Y2O2S:Eu3+, Mg2+, Ti4+ Hollow Nanospheres via a Template‐Free Route.
Authors: Deng Suqing , Xue Zhiping , Liu Yingliang , Lei Bingfu , Xiao Yong , Zheng Mingtao 
Published: November 2012

AbstractThe title hollow nanospheres are synthesized by precipitation from a solution of Y(NO3)3, Eu(NO3)3, Mg(NO3)2, and Ti(SO4)2 in ethylene glycol and poly(vinyl pyrrolidone) using an EtOH solution of thiourea (autoclave, 200 °C) followed by calcination with CS2 as a sulfurization agent (graphite crucible, 800—1100 °C, 4 h).
ChemInform Abstract: Effects of Nickel‐Doped Lithium Vanadium Phosphate on the Performance of Lithium‐Ion Batteries.
Authors: Zhang Yong , et al. et al. 
Published: November 2012

AbstractA series of Ni‐doped Li3V2(PO4)3 composites as new cathode materials for lithium ion batteries is synthesized by a microwave‐assisted sol—gel method.
ChemInform Abstract: Cerium(IV) Tellurite Halides [Ce2Te7O17]X2 (X: Cl‐ or Br‐): The First Cerium‐Containing Cationic Frameworks.
Authors: Lin Jian , Diwu Juan , Cross Justin N. , Villa Eric M. , Albrecht‐Schmitt Thomas E. 
Published: November 2012

AbstractThe structures of title compounds (III) are determined by single crystal XRD.
ChemInform Abstract: Influence of the Organic Species and Oxoanion in the Synthesis of Two Uranyl Sulfate Hydrates, (H3O)2 [(UO2)2(SO4)3(H2O)] ·7H2O and (H3O)2 [(UO2)2(SO4)3(H2O)] ·4H2O, and a Uranyl Selenate‐Selenite [C5H6N] [(UO2)(SeO4)(HSeO3)].
Authors: Jouffret Laurent J. , Wylie Ernest M. , Burns Peter C. 
Published: November 2012

AbstractThe crystal structures of (II), (III), and (IV) are determined by single crystal XRD.
ChemInform Abstract: A Pineno‐Salen Type Catalyst for the Enantioselective Nozaki—Hiyama—Kishi Reaction.
Authors: Dhondge Attrimuni P. , Shaikh Ajam C. , Chen Chinpiao 
Published: November 2012

AbstractOne of the newly synthesized pineno‐salen type ligands is used in the enantioselective Nozaki—Hiyama—Kishi allylation of alkyl and (hetero)aryl aldehydes with allyl bromide.
ChemInform Abstract: Preparation of Ionic Liquid‐Based Vilsmeier Reagent from Novel Multi‐purpose Dimethyl Formamide‐Like Ionic Liquid and Its Application.
Authors: Hullio Ahmed Ali , Mastoi G. M. 
Published: November 2012

AbstractThe complex consisting of cyanuric chloride and an imidazole‐based DMF‐like ionic liquid forms the reactive intermediate MPFIL (multipurpose functional ionic liquid) whose capacity to achieve more useful organic transformation is tested in numerous types of reactions.
ChemInform Abstract: Iron‐Catalyzed Reductive Radical Cyclization of Organic Halides in the Presence of NaBH4: Evidence of an Active Hydrido Iron(I) Catalyst.
Authors: Ekomie Audrey , Lefevre Guillaume , Fensterbank Louis , Lacote Emmanuel , Malacria Max , Ollivier Cyril , Jutand Anny 
Published: November 2012

AbstractBased on electrochemical investigations this reaction is proposed to proceed via electron‐transfer activation of the halide mediated by an in situ generated anionic hydrido iron(I) species.
ChemInform Abstract: The Palladium‐Catalyzed Cross‐Coupling Reactions of Trifluoroethyl Iodide with Aryl and Heteroaryl Boronic Acid Esters.
Authors: Liang Apeng , Li Xinjian , Liu Dongfeng , Li Jingya , Zou Dapeng , Wu Yangjie , Wu Yusheng 
Published: November 2012

AbstractThe protocol allows for a convenient introduction of trifluoroethyl groups into a variety of aryl and heteroaryl moieties under mild conditions.
ChemInform Abstract: Organic Acid Induced Olefination Reaction of Lactones.
Authors: Yanai Hikaru , Taguchi Takeo 
Published: November 2012

Abstract(Z)‐Selective olefination of several lactones (I), (IV) and (VI) with ketene silyl acetals (II) is achieved by catalysis of carbon acids having a bis(trifluoromethylsulfonyl)methyl group as an acidic functionality.
ChemInform Abstract: Straightforward Reductive Esterification of Carbonyl Compounds with Carboxylic Acids Through Tosylhydrazone Intermediates.
Authors: Garcia‐Munoz Angel‐Humberto , Tomas‐Gamasa Maria , Perez‐Aguilar M. Carmen , Cuevas‐Yanez Erick , Valdes Carlos 
Published: November 2012

AbstractA stepwise approach is found to be suitable especially for the preparation of benzhydryl or benzyl esters [cf.(VI)] via diazo intermediates.
ChemInform Abstract: Preparation of Enol Ester Epoxides and Their Ring‐Opening to α‐Silyloxyaldehydes.
Authors: Friestad Gregory K. , Sreenilayam Gopeekrishnan , Cannistra Joseph C. , Slominski Luke M. 
Published: November 2012

AbstractThe (Z)‐selective Ru‐catalyzed anti‐Markovnikov addition of aromatic carboxylic acids to alkynes is followed by epoxidation with dimethyldioxirane, prepared in situ.
ChemInform Abstract: One‐Pot Cascade Leading to Direct α‐Imidation of Ketones by a Combination of N‐Bromosuccinimide and 1,8‐Diazabicyclo[5.4.1]undec‐7‐ene.
Authors: Wei Ying , Lin Shaoxia , Liang Fushun 
Published: November 2012

AbstractNBS provides both electrophilic bromine and nucleophilic nitrogen sources.
ChemInform Abstract: Lewis Acid Mediated Selective Monohydrolysis of Geminal Diesters: Synthesis of Functionalized Malonic Acid Half Esters.
Authors: Ilangovan Andivelu , Kumar Rajendran Ganesh , Kaushik Mahabir Prasad 
Published: November 2012

AbstractA broad spectrum of diester substrates with an amino function is successfully hydrolyzed within a short time to afford exclusively (E)‐configurated monoesters at the geminal site.
ChemInform Abstract: Efficient and Reusable Amine‐Functionalized Polyacrylonitrile Fiber Catalysts for Knoevenagel Condensation in Water.
Authors: Li Guowei , Xiao Jia , Zhang Wenqin 
Published: November 2012

AbstractA series of fiber catalysts promotes the condensation of a wide range of aromatic aldehydes with active methylene compounds.
ChemInform Abstract: Noncovalent Organocatalytic Synthesis of Enantioenriched Terminal Aziridines with a Quaternary Stereogenic Center.
Authors: De Fusco Claudia , Fuoco Tiziana , Croce Gianluca , Lattanzi Alessandra 
Published: November 2012

AbstractThe process allows the access to various aziridine structures bearing a functionalized asymmetric center.
ChemInform Abstract: Copper(I)‐Catalyzed [3 + 1] Cycloaddition of Alkenyldiazoacetates and Iminoiodinanes: Easy Access to Substituted 2‐Azetines.
Authors: Barluenga Jose , Riesgo Lorena , Lonzi Giacomo , Tomas Miguel , Lopez Luis A. 
Published: November 2012

AbstractThe reaction is proposed to proceed via Cu(I)‐catalyzed aziridination of the alkene moiety followed by Cu(I)‐catalyzed ring expansion of the resulting aziridinyldiazo intermediate.
ChemInform Abstract: Efficient Synthesis of Diverse Hetero‐Bis‐Metalated Alkenes as Modular Reagents Towards Highly Conjugated and Isolated Olefinic Systems.
Authors: Altendorfer Mario , Menche Dirk 
Published: November 2012

AbstractA convergent, palladium‐catalyzed fragment coupling strategy is applied to the concise and modular construction of the polyene side chains of the potent polyketide antibiotic etnangien.
ChemInform Abstract: A Novel One‐Pot Synthesis of Fully Substituted Thiophen‐2(3H)‐ones Using N,N‐Disubstituted Thioamides.
Authors: Zali‐Boeini Hassan , Pourjafarian Fatemeh 
Published: November 2012

AbstractBase‐mediated reaction of N,N‐disubstituted thioamides (I) with chloro(phenyl)acetyl chloride (II) provides a novel convenient access towards polysubstituted thiophene derivatives (III).
ChemInform Abstract: gem‐Dialkylthio Vinylallenes: Alkylthio‐Regulated Reactivity and Application in the Divergent Synthesis of Pyrroles and Thiophenes.
Authors: Zhang Jingping , et al. et al. 
Published: November 2012

Abstractgem‐Dialkylthio vinylallenes are successfully applied to the novel and powerful syntheses of a wide range of pyrroles and thiophenes.
ChemInform Abstract: Indole Cyanation via C—H Bond Activation under Catalysis of Ru(III)‐Exchanged NaY Zeolite (RuY) as a Recyclable Catalyst.
Authors: Khorshidi Alireza 
Published: November 2012

AbstractIndole substrates react with (II) as a nontoxic, slow cyanide releasing agent in the presence of RuY to yield 3‐cyanated derivatives regioselectively.
ChemInform Abstract: Synthesis of N‐Substituted Carbazolones from α‐Iodo Enaminones via Pd(0)‐Catalyzed Intramolecular Coupling under Microwave Irradiation.
Authors: Yun Xi‐Liu , Bi Wen‐Ying , Huang Jian‐Hui , Liu Yu , Zhang‐Negrerie Daisy , Du Yun‐Fei , Zhao Kang 
Published: November 2012

AbstractThe process can also be applied to substrates bearing a strong electron‐withdrawing group such as ‐NO2.
ChemInform Abstract: One‐Pot Synthesis of 2,1‐Benzisoxazoles (Anthranils) by a Stannous Chloride Mediated Tandem Reduction—Heterocyclization of 2‐Nitroacylbenzenes under Neutral Conditions.
Authors: Chauhan Jay , Fletcher Steven 
Published: November 2012

AbstractOptimized conditions are developed, which allow the conversion of substrates bearing acid‐labile protecting groups.
ChemInform Abstract: Synthesis of Imidazo[2,1‐b]‐1,3,4‐thiadiazoles in DABCO as an Efficient and Recyclable Catalyst.
Authors: Tiwari Kamleshwar , Verma Pankaj Kumar , Singh Shyam Babu , Singh Jagdamba 
Published: November 2012

AbstractAn efficient and general method is described for the synthesis of imidazothiadiazoles (III) (12 examples) via DABCO‐catalyzed reaction of 2‐aminothiadiazoles with phenacyl bromides.
ChemInform Abstract: Synthesis, Benzodiazepine Receptor Binding and Molecular Modelling of Isochromeno[4,3‐c]pyrazol‐5(1H)‐one Derivatives.
Authors: Maggio B. , Raffa D. , Raimondi M. V. , Plescia F. , Trincavelli M. L. , Martini C. , Meneghetti F. , Basile L. , Guccione S. , Daidone G. 
Published: November 2012

AbstractA series of isochromeno[4,3‐c]pyrazol‐5(1H)‐one derivatives (III) is prepared and tested for their ability to displace specific [3H]flunitrazepam from bovine brain membranes.
ChemInform Abstract: New N‐Arylamino Biquinoline Derivatives: Synthesis, Antimicrobial, Antituberculosis, and Antimalarial Evaluation.
Authors: Shah Nimesh M. , Patel Manish P. , Patel Ranjan G. 
Published: November 2012

AbstractThe reaction between quinolines (I), enhydrazinoketones (II), and malononitrile (IV) involves a Knoevenagel condensation, Michael addition, cyclization, and tautomerization to provide the final products (IV).
ChemInform Abstract: Near Room Temperature Cross‐Coupling Reactions of Arene Boronic Acids with a Quinoxaline 1,4‐Dioxide Benzylsulfanyl Derivatives.
Authors: Dahbi Samir , Bisseret Philippe 
Published: November 2012

AbstractFor the first time the title reaction involving a readily preparable quinoxaline 1,4 dioxide is developed under mild conditions.
ChemInform Abstract: Synthesis of Hexahydro[1,4]diazocino[7,8,1‐jk]carbazoles and 1‐Methoxy‐9‐(β‐vinylethylamino)ethylcarbazoles.
Authors: Voskressensky L. G. , Granik V. G. , Borisova T. N. , Titov A. A. , Grishina E. I. , Sorokina E. A. , Varlamov A. V. 
Published: November 2012

AbstractReaction of N‐ethylpyrazinocarbazole (IIIa) with acetylene derivatives (IV) in MeCN affords the title diazocinocarbazoles (V), which are representatives of a previously unknown heterocyclic system.
ChemInform Abstract: Guanacastane‐Type Diterpenoids with Cytotoxic Activity from Coprinus plicatilis.
Authors: Liu Yuanzhen , Li Yaoyao , Ou Yixin , Xiao Shuyan , Lu Chunhua , Zheng Zhonghui , Shen Yuemao 
Published: November 2012

AbstractFour new guanacastane‐type diterpenoids (I)—(IV) are isolated along with the known guanacastepene E from a basidiomycete of the macro‐fungi Coprinus plicatilis 82.
ChemInform Abstract: Natural Products as Templates for Bioactive Compound Libraries. Part 3. Novel Heterocycles and Peptidomimetics Generated from Anabasine by Isocyanide‐Based Multicomponent Reactions.
Authors: Sandulenko Y. , Krasavin M. 
Published: November 2012

AbstractTwo series of novel drug‐like alkaloid derivatives are synthesized starting from natural anabasine (I) using prominent isocyanide‐based multicomponent processes.
ChemInform Abstract: 3‐Bromo‐3‐deazaneplanocin and 3‐Bromo‐3‐deazaaristeromycin: Synthesis and Antiviral Activity.
Authors: Liu Chong , Chen Qi , Schneller Stewart W. 
Published: November 2012

AbstractTo achieve a preliminary indication that 3‐substituted 3‐deazaneplanocins could provide a framework for antiviral drug discovery, the 3‐bromo‐3‐deaza analogue of the naturally occurring, broad spectrum antiviral activity possessing neplanocin is synthesized in 5 steps from 3‐deazaadenine.
ChemInform Abstract: Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells.
Authors: Zheng Shuyan , Fu Runzhong , Shen Zhengwu 
Published: November 2012

AbstractHirtellanine B (VI), isolated from the roots of Campylotropis hirtella Schindl, exhibits moderate B lymphocyte suppression activity, T lymphocyte supression activity and in vitro inhibition of the proliferation of Jurkat, Raji and K562 cell lines.
Disposable Flat Panel Airlift Photobioreactors
Authors: Bergmann Peter , Ripplinger Peter , Beyer Lars , Trösch Walter 
Published: November 2012

AbstractSingle‐use technology based on disposable bioreactors is gaining more and more importance in biotechnology due its high flexibility, easy handling and ready‐to‐use character when supplied. A disposable, low‐cost, transparent flat panel airlift photobioreactor with optimized flow regime for the efficient cultivation of microalgae and production of microalgal metabolites is presented and possible applications are discussed.