bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBELAJARAN BERBASIS RISET (RESEARCH-BASED LEARNING) UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS, BERPIKIR KREATIF DAN BERPIKIR REFLEKTIF SISWA DALAM PEMBELAJARAN BIOLOGI [RESEARCH-BASED LEARNING TO IMPROVE STUDENTS' CRITICAL THINKING, CREATIVE THINKING AND REFLECTIVE THINKING SKILLS IN BIOLOGY LEARNING]
Authors: Supit Patryks Gerald Yeheskiel , Winardi Yonathan 
Published: July 2024

<p class="abstrak"><strong>Abstract</strong></p><p class="abstrak">The development of the 21st century learning era and the development of the industrial revolution 4.0, brings the world of education into the arena of competition in all aspects of life. Current advances in science and technology provide their own challenges for teachers in designing a learning model to produce learners according to 21st century competencies. Current education has not been able to produce the quality of 21st century learners who have the ability to think critically, think creatively and think reflectively. It is a challenge for an educator to design the right learning model. This study aims to see whether the application of research-based learning model can develop students' critical thinking, creative thinking, and reflective thinking skills in learning biology. The method used in this research is Classroom Action Research according to Mc. Kernans which was conducted for two cycles in class XI Major A. Data collection techniques used rubrics to measure the achievement of indicators through tests. The results showed that the application of the research-based learning model was able to improve students' critical thinking, creative thinking, and reflective thinking skills in learning biology.</p><p class="abstrak"> </p><p class="abstrak"><strong>Bahasa Indonesia Abstrak</strong></p><p class="abstrak">Perkembangan era 21 <em>century</em> <em>learning</em> dan perkembangan revolusi industri 4.0, membawa dunia pendidikan memasuki arena kompetisi dalam segala aspek kehidupan. Kemajuan ilmu pengetahuan dan teknologi saat ini memberikan tantangan tersendiri bagi guru dalam merancang sebuah model pembelajaran untuk menghasilkan peserta didik sesuai kompetensi abad 21 saat ini. Pendidikan saat ini belum mampu menghasilkan kualitas peserta didik abad 21 yang memiliki kemampuan berpikir kritis, berpikir kreatif dan berpikir reeflektif. Sebuah tantangan tersendiri bagi seorang pendidik dalam merancang sebuah pemodelan pembelajaran yang tepat. Penelitian ini bertujuan untuk melihat apakah penerapan model <em>research-based learning</em> mampu mengembangkan kemampuan berpikir kritis, berpikir kreatif, dan berpikir reflektif peserta didik dalam pembelajaran biologi. Metode yang digunakan dalam penelitian ini adalah Penelitian Tindakan Kelas oleh Mc. Kernans yang dilakukan selama dua siklus di kelas XI Major A. Instrumen penelitian berupa tes yang telah divalidasi oleh dua orang ahli. Hasil penelitian ini menyatakan bahwa penerapan model <em>research-based learning</em> mampu meningkatkan kemampuan berpikir kritis, berpikir kreatif, dan berpikir reflektif peserta didik dalam pembelajaran biologi.</p>
Efficacy evaluation of particle films as oviposition deterrent against <i>Drosophila suzukii</i> in Austrian vineyards
Authors: Krutzler Michael , Brader Günter , Menhart Karl , Madercic Monika , Riedle-Bauer Monika 
Published: July 2024

Drosophila suzukii Matsumura (Diptera: Drosophilidae) is a polyphagous invasive vinegar fly. Females can penetrate certain soft-skinned grapevine varieties with their strong serrated ovipositor to lay their eggs within berries, which eventually leads to the decay and collapse of grapes. Alternative pest control options were tested in practically oriented field trials set up in two vineyards in Styria. The effect of the mineral particle films diatomaceous earth, kaolin and muscovite mica was compared to an untreated control. All products were complemented with wetting agents to increase the efficacy and/or the rain resistance of the film. Due to the long waiting times after application in organic production, only some of the trials also comprised a comparable insecticide variant (Spinosad). Treatments were applied from the beginning of infestations until harvest, and berries were sampled once to twice a week, depending on pest pressure. Evaluation of treatment effects was based on a microscopic analysis of berries for oviposition and a visual evaluation of the clusters. Both kaolin and diatomaceous earth led to a statistically significant reduction in oviposition and to a significantly improved macroscopic appearance of clusters compared to the control, whereas the effect of muscovite mica was negligible. A direct comparison of particle film and spinosad treatment was only expedient in one experiment, and in this case, the effect of kaolin on oviposition was significantly superior. Kaolin and diatomaceous earth might complement established integrated pest management practices against Drosophila suzukii and contribute to the reduction of chemical plant protection agents in the future.
Prevalence of Cerebral Visual Impairment in Developmental and Epileptic Encephalopathies: a systematic review protocol
Authors: Perinelli Martina Giorgia , Abbott Megan , Balagura Ganna , Riva Antonella , Amadori Elisabetta , Verrotti Alberto , Demarest Scott , Striano Pasquale 
Published: July 2024

Abstract

Background
Developmental and Epileptic Encephalopathies (DEEs) are defined by drug-resistant seizures and neurodevelopmental disorders. Over 50% of patients have a genetic cause. Studies have shown that patients with DEEs, regardless of genetic diagnosis, experience a central visual function disorder known as Cerebral (cortical) Visual Impairment (CVI). The prevalence of CVI in DEE patients is currently unknown. A quantitative synthesis of existing data on prevalence rates of this condition would aid in understanding the magnitude of the problem, outlining future research, and suggesting the need for therapeutic strategies for early identification and prevention of the disorder.
Methods
This systematic review and meta-analysis protocol adheres to the PRISMA-P statement and utilizes the JBI Manual for Evidence Synthesis, focusing on the prevalence of cerebral visual impairments in patients with developmental and epileptic encephalopathy. Eligibility criteria are established following the CoCoPop framework. Comprehensive database searches will include MEDLINE, EMBASE, Science Direct, Scopus, PsychINFO, Wiley, Highwire Press, and the Cochrane Library of Systematic Reviews. The risk of bias will be assessed using the JBI Critical Appraisal Checklist for Studies reporting prevalence data. Heterogeneity will be evaluated using Cochran’s Q statistic and the I2 statistic. Summary tables and narrative text will present characteristics of the included studies. Pooled prevalence estimates will be calculated using a random-effects model and presented graphically in forest plots. If heterogeneity is high, a narrative summary will be provided. The quality of evidence will be assessed using the GRADE methodology.
Discussion
This protocol outlines a systematic review and meta-analysis that aims to identify, collect, evaluate, and integrate epidemiological knowledge related to the prevalence of CVI in patients with DEEs. To the best of our knowledge, no other systematic review and meta-analysis has addressed this specific issue. The results will provide useful information for understanding the extent of the problem, outlining future research, and suggesting the need for early identification strategies.
Systematic review registrations:
This Systematic Review Protocol was registered in PROSPERO (CRD42023448910).
Electrocatalytic upcycling of high-pressure captured CO2
Authors: Lu Xu , Huang Liang , Gao Ge , Zhao Jiwu , Roberts William 
Published: July 2024

Abstract

Electrochemical upcycling of captured CO2 – typically under high pressure – holds significant potential to bridge between CO2 emissions and hydrocarbon commodities. However, this conceptual CO2 value chain is yet to be demonstrated. Here, we showcase the valorization of gas-phase high-pressure captured CO2 (HP-cCO2) into ethylene (C2H4) through electrochemical CO2 reduction (CO2R). Guided by theoretical calculations, we devise a single-atom In alloyed Cu catalyst (In1/Cu), which, when integrated into a custom-built high-pressure membrane electrode assembly (MEA) under 20 bar, affords up to 85% Faradaic efficiency (FE) and up to 750 mA cm−2 partial current density toward C2H4. The interplay of theory and high-pressure operando methods links the exceptional performance to the pressure-modulated adsorption configuration of the *CO intermediate, and the elevated CO2 coverage. We also reveal the pivotal role of pressure in mitigating the salt precipitation – a long-standing challenge in the field – by relocating the bicarbonate formation to the catalyst-membrane interface. This was agreed upon by C2H4 FE that is sustained above 80% for 1,500 hours at 600 mA cm−2 under 20 bar. This proof-of-concept, by electrochemically producing C2H4 from HP-cCO2 and re-capturing the residue CO2, delivers industrial grade 99.9% purity C2H4 and exhibits prospect of turning the otherwise costly CO2 capture process into a profit. Energy analysis suggested that directly valorizing HP-cCO2, instead of depressurizing it to accommodate conventional ambient-pressure CO2R and repressurizing the effluents for gas product separation, is essential to minimize the energy consumption.
Portal Venous Gas from Decompression Sickness – Case Report and Literature Review
Authors: Koujah Dalia , O'Neill Liam , Patel Tarang 
Published: July 2024

Abstract

Purpose To present a case report involving a rare case of a scuba diver presenting with portal venous gas (PVG) from decompression sickness (DCS).Methods Patient records were reviewed for clinical presentation, imaging findings, treatment course, and symptomatic resolution. A literature review was conducted to provide support for the case and provide background information for the unique presentation.Results We present a case of PVG secondary to DCS in an experienced scuba diver after repeated dives to depths greater than 150 meters. Patient presented with nausea, vomiting, confusion, nystagmus, ataxia, and a rash on the upper chest and back. After PVG was identified on CT, hyperbaric oxygen therapy was initiated. Symptoms resolved within the span of 3 days.Conclusion PVG is a rare and easily treatable phenomenon in DCS. It is important to identify the etiology of the PVG in the case of DCS to enact appropriate treatment.
DNA data storage: a generative tool for data encoding motifs
Authors: Brunmayr Samira , Sella Omer Shimon , Heinis Thomas 
Published: July 2024

Abstract

DNA possesses extremely high information density and durability. In order to become a commercially viable medium such as magnetic tape and hard disk drives, the cost per bit has to decrease considerably, while the write bandwidth needs to increase. Both are governed by DNA synthesis, the process of writing data to DNA, which is currently very expensive and slow. Assembly of DNA strands from motifs, i.e. short DNA sequences, is an economical and faster way of representing data using DNA. Each motif carries a letter in an alphabet. Trading the quaternary alphabet {A,C,T,G} for longer fragments, namely motifs, allows an increase in write bandwidth and reduces cost. The success of the underlying chemistry, specifically with the assembly of motifs into polymers that faithfully represent the source binary data, is sensitive to the formation of secondary structures and the correct annealing of the motifs in a unique way. In this work, we develop a mathematical framework and a method to generate a set of motifs that agree with a predefined set of constraints regardless of the order they are combined. We show that our approach generates motifs that always conform to the constraints with high probability, contrary to randomly generated motifs.
Amyloid deposition and its association with depressive symptoms and cognitive functions in late-life depression: A longitudinal study using amyloid- β PET images and neuropsychological measurements
Authors: Kim Kiwon , Jang Yoo Jin , Shin Jeong-Hyeon , Park Mi Jin , Kim Hyun Soo , Seong Joon-Kyung , Jeon Hong Jin 
Published: July 2024

Abstract

Background: Although depression is linked to an increased risk of dementia, the association between late-onset depression (LOD) and amyloid burden remains unclear. This study aimed to determine amyloid deposition in patients with LOD compared to healthy controls (HC) using amyloid-beta (Aβ) positron emission tomography (PET) images and neuropsychological assessments.
Methods: Forty patients first diagnosed with major depressive disorder after the age of 60 (LOD) and twenty-one healthy volunteers (HC) were enrolled. Depression and anxiety were evaluated using the 17-item Hamilton Depression Scale, Hamilton Anxiety Rating Scale, and Clinical Global Impression Scale. Cognitive function was assessed using the Korean versions of the Mini-Mental Status Examination, Montreal Cognitive Assessment, and Seoul Neuropsychological Screening Battery at baseline and 3-month follow-up. 18F-florbetapir PET images were co-registered with T1-weighted magnetic resonance images.
Results: There was no significant difference in Aβ deposition between LOD and HC groups. No significant correlation between Aβ burden and depressive symptom severity was found in LOD patients. Higher somatic anxiety was correlated with lower Aβ burden in multiple brain regions, including the left inferior frontal lobe (p = 0.009), right anterior cingulate (p = 0.003), and right superior frontal lobe (p = 0.009). Despite cognitive recovery in areas such as attention (Digit Span Forward, p = 0.026), memory (Auditory Verbal Learning Test Recall Total, p = 0.010; Rey Complex Figure Test Delayed Recall, p = 0.039), and frontal executive function (Contrasting Program, p = 0.033) after three months of antidepressant treatment, cognitive improvement showed no association with amyloid deposition.
Conclusions: These findings suggest distinct mechanisms may underlie amyloid deposition in neurodegenerative changes associated with depression. While amyloid burden in specific brain regions negatively correlated with somatic anxiety, it showed no significant correlation with the severity of depression or overall cognitive function.
ATPIF-1 knockout attenuates mitochondrial mPTP opening but does not diminish cardiac ischemic/reperfusion injury.
Authors: Westenbrink B. Daan , Sánchez-Aguilera Pablo , Saucedo-Orozco Huitzilihuitl , Schouten Marloes , Lavandero Sergio , de Boer Rudolf , Silljé Herman , Puspitarani R.A.D.A 
Published: July 2024

Abstract

Ischemic conditions can flip the action of mitochondrial ATP-synthase from an ATP producing to an ATP consuming enzyme. The mitochondrial protein ATPase inhibitory factor 1 (ATPIF-1) prevents ATP-synthase reversal, thereby preserving ATP during ischemia. Recent evidence suggests that ATPIF-1 may also have detrimental effects on mitochondrial calcium (Ca2+) handling and mitochondrial permeability transition pore (mPTP) opening under ischemic conditions, challenging conventional views on the function of ATPIF-1.
To determine the role of ATPIF-1 during myocardial ischemia we studied Ca2+ retention capacity, cardiac injury and cardiac remodeling after myocardial infarction (MI) in ATPIF-1 knockout (ATPIF-1 KO) mice and wild-type (WT) littermates. Mitochondrial Ca2+ retention capacity of isolated cardiac mitochondria of ATPIF-1 KO of ATPIF1-KO mice displayed a 1.3-fold higher threshold for mPTP opening compared to WT mice. However, when subjected 45 minutes left coronary artery (LCA) ligation followed by 48 hours of reperfusion, myocardial infarct size, left ventricular function and remodeling were all comparable between genotypes. Moreover, when subjected to permanent LCA ligation loss of ATPIF-1 KO also did not influence cardiac function or cardiac remodeling. Instead, ATPIF-1 KO mice displayed a 57.3% increase in interstitial fibrosis compared to WT mice. In conclusion, ATPIF-1 KO attenuates mPTP formation, however it does not mitigate myocardial I/R injury or post-MI remodeling. These findings challenge the concept that ATPIF-1 is critical for the response to I/R injury.
The evolution and maintenance of trioecy with cytoplasmic male sterility
Authors: Nguyen Mai Thu , Pannell John 
Published: July 2024

Abstract

Trioecy, the co-existence of females, males and hermaphrodites, is a rare sexual system in plants. Previous models have identified pollen limitation as a necessary condition for the evolution of trioecy from hermaphroditism, whereby the seed-production and pollen production of females and males, respectively, relative to those of hermaphrodites are compromised by self-fertilization by hermaphrodites under pollen- limitation. Here, we investigate the evolution of trioecy via the invasion of cytoplasmic male sterility (CMS) into androdioecious populations in which hermaphrodites co-occur with males and where the male determiner is linked to a (partial) fertility restorer. We show that the presence of males renders invasion by CMS more difficult. However, the presence of males also facilitates the maintenance of trioecy even in the absence of pollen limitation by negative frequency-dependent selection whereby males reduce the fitness of females by siring sons that cannot transmit CMS. We discuss our results in light of empirical observations of trioecy in plants.
RETRACTED: Cross-Cultural Adaptation and Reliability of the Inventory of Vicarious Posttraumatic Growth and research of its influencing factors: A Cross-Sectional Study
Authors: Cai Yitong , Li Yifei , Zou Jie , Zhang Jie , Qu Chaoran , Zhang Jingping , Luo Weixiang 
Published: July 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Low-dose rituximab regimen does not increase severe COVID-19 risk in patients with neuroimmune diseases during the pandemic: a cross-sectional study
Authors: Li Lin , Yao Dan , Li Chuan , Hao Yunfeng , Zhao Chao , Yan Qi , Zhou Xuan , Li Ying , Dang Yuting , Han Lin , Zhang Rong , Liu Juntong , Zhu Wenping , Liu Shuyu , Gao Lan , Du Ying , Zhang Wei 
Published: July 2024

Abstract

A retrospective study was conducted to evaluate the impact of low-dose rituximab (RTX) regimen on the severity of coronavirus disease 2019 (Covid-19) in patients with neuroimmune diseases (PwNIDs) at Tangdu Hospital, Fourth Military Medical University from July 2017 to December 2022. A total of 70 PwNIDs were enrolled, of which 39 contracted COVID-19. The co-residents of these PwNIDs, serving as the control group, comprised 94 individuals, among whom 56 contracted COVID-19. However, there was no significant difference in the severity of COVID-19, including severe cases or death, between the two groups. Among PwNIDs, there were no notable differences observed in age, sex, underlying conditions, comorbidities, cumulative RTX dosages, or the duration since the last RTX infusion between the infected and uninfected groups. Among the PwNIDs who contracted COVID-19, 89.7% (35/39) stated that the virus had no influence on their existing conditions. Only 10.3% (4/39) reported worsened previous symptoms without requirement of hospitalization, and none developed new-onset neurological symptoms requiring acute-phase treatment. The administration of a low-dose RTX regimen does not increase the risk of COVID-19 or severe illness in PwNIDs, irrespective of the cumulative RTX dosages or the duration since the last RTX infusion. Moreover, COVID-19 does not seem to significantly exacerbate underlying neuroimmune disorders in these individuals.
The Effect of Stingless Bee Honey Mouthrinse on Dental Plaque Accumulation: A Randomised Clinical Trial
Authors: Hayei Nur Ayman Abdul , Reduan Misya Humaira , Zulkaflee Nor Suhaira , Baharin Nor Haliza Mat , Sabarudin Muhammad Annurdin , Azis Nik Madihah Nik 
Published: July 2024

Abstract

Background: Mouthrinses are recommended as an adjunct to mechanical methods in oral hygiene procedures for the prevention and management of periodontal diseases. Stingless bee honey (SBH) is a natural food with many health benefits. It has been reported to be beneficial for the oral cavity such as antibacterial, anti-inflammatory, and has healing properties making it a potential therapeutic agent in periodontal therapy. This study aims to investigate the ability of stingless bee honey mouthrinse to reduce plaque accumulation and to assess the patients’ acceptance towards its use. Methods: This is a pilot randomised clinical trial performed on volunteers (N=30) with healthy gingiva and/or mild gingivitis randomly prescribed with SBH, chlorhexidine (CHX) or normal saline (NS) mouthrinse without oral hygiene practice for three days. Plaque accumulation and patient perception were recorded post-intervention using plaque score and visual analogue scale (VAS) respectively.
Results: Post-intervention after three days, there was no significant change in plaque score in SBH and NS groups (p>0.05) compared to baseline. Significant plaque score reduction was found in the CHX group (p<0.05) compared to the baseline. A significantly better taste and lower burning sensation were reported in the SBH group compared to the NS and CHX groups respectively.
Conclusions: SBH mouthrinse effectively prevented a significant increase in plaque accumulation in the absence of oral hygiene, with less burning sensation. However, chlorhexidine has a better ability to prevent plaque accumulation.
Trial registration: This study was retrospectively registered on 24/1/2024 at ClinicalTrials. gov (No. NCT06223243).