bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative prediction of nodal status using clinical data and artificial intelligence derived mammogram features enabling abstention of sentinel lymph node biopsy in breast cancer
Authors: Rejmer Cornelia , Dihge Looket , Bendahl Pär-Ola , Förnvik Daniel , Dustler Magnus , Rydén Lisa 
Published: July 2024

IntroductionPatients with clinically node-negative breast cancer have a negative sentinel lymph node status (pN0) in approximately 75% of cases and the necessity of routine surgical nodal staging by sentinel lymph node biopsy (SLNB) has been questioned. Previous prediction models for pN0 have included postoperative variables, thus defeating their purpose to spare patients non-beneficial axillary surgery. We aimed to develop a preoperative prediction model for pN0 and to evaluate the contribution of mammographic breast density and mammogram features derived by artificial intelligence for de-escalation of SLNB.Materials and methodsThis retrospective cohort study included 755 women with primary breast cancer. Mammograms were analyzed by commercially available artificial intelligence and automated systems. The additional predictive value of features was evaluated using logistic regression models including preoperative clinical variables and radiological tumor size. The final model was internally validated using bootstrap and externally validated in a separate cohort. A nomogram for prediction of pN0 was developed. The correlation between pathological tumor size and the preoperative radiological tumor size was calculated.ResultsRadiological tumor size was the strongest predictor of pN0 and included in a preoperative prediction model displaying an area under the curve of 0.68 (95% confidence interval: 0.63–0.72) in internal validation and 0.64 (95% confidence interval: 0.59–0.69) in external validation. Although the addition of mammographic features did not improve discrimination, the prediction model provided a 21% SLNB reduction rate when a false negative rate of 10% was accepted, reflecting the accepted false negative rate of SLNB.ConclusionThis study shows that the preoperatively available radiological tumor size might replace pathological tumor size as a key predictor in a preoperative prediction model for pN0. While the overall performance was not improved by mammographic features, one in five patients could be omitted from axillary surgery by applying the preoperative prediction model for nodal status. The nomogram visualizing the model could support preoperative patient-centered decision-making on the management of the axilla.
Transplant-associated thrombotic microangiopathy in pediatrics: incidence, risk factors, therapeutic options, and outcome based on data from a single center
Authors: Kafa Kinan , Hoell Jessica I. 
Published: July 2024

BackgroundTransplant-associated thrombotic microangiopathy (TA-TMA) is a critical complication of hematopoietic stem cell transplantation. Awareness about TA-TMA has increased in recent years, resulting in the implementation of TA-TMA screening in most centers.MethodsRetrospective analysis of children who underwent autologous or allogeneic hematopoietic stem cell transplantation at our center between January 2018 and December 2022 was conducted to evaluate the incidence, clinical features, and outcomes of TA-TMA following the administration of different therapeutic options.ResultsA total of 45 patients comprised the study cohort, of whom 10 developed TA-TMA with a cumulative incidence of 22% by 100 days after transplantation. Patients with and without TA-TMA in our cohort displayed an overall survival of 80% and 88%, respectively (p = 0.48), and a non-relapse mortality of 0% and 5.7%, respectively (p = 0.12), at 1 year after transplantation. Risk factors for TA-TMA development included allogeneic transplantation and total body irradiation-based conditioning regime. Among the 10 patients with TA-TMA, 7 did not meet the high-risk criteria described by Jodele and colleagues. Of these seven patients, two responded to calcineurin-inhibitor withdrawal without further therapy and five developed multiorgan dysfunction syndrome and were treated with anti-inflammatory steroids (prednisone), and all responded to therapy. The three patients with high-risk TA-TMA were treated with complement blockade or prednisone, and all responded to therapy.ConclusionTA-TMA is a multifactorial complication with high morbidity rates. Patients with high-risk TA-TMA may benefit from complement blockade using eculizumab. No consensus has been reached regarding therapy for patients who do not meet high-risk criteria. Our analysis showed that these patients may respond to anti-inflammatory treatment with prednisone.
The real-world safety of oseltamivir and baloxavir marboxil in children: a disproportionality analysis of the FDA adverse event reporting system
Authors: Wei Wei , Huang Liang , Bai Yingtao , Chang En , Liu Jinfeng 
Published: July 2024

BackgroundOseltamivir and baloxavir marboxil are the two primary oral drugs approved by the Food and Drug Administration (FDA) for treating influenza. Limited real-world evidence exists on their adverse events in children. The purpose of this study was to explore the adverse event (AE) profiles of oseltamivir and baloxavir marboxil in children based on the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database.MethodsFAERS reports were collected and analyzed from the first quarter of 2019 to the third quarter of 2023. Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi-item gamma Poisson shrinker (MGPS) algorithms, were employed in data mining to quantify the signals of oseltamivir and baloxavir marboxil-related AEs.ResultsA total of 464 reports of AEs to oseltamivir as the “primary suspect (PS)” and 429 reports of AEs to baloxavir marboxil as the “PS” were retrieved in pediatric patients. A total of 100 oseltamivir-induced AE signals were detected in 17 system organ classes (SOCs), and 11 baloxavir marboxil-induced AE signals were detected in 6 SOCs after complying with the four algorithms simultaneously. Categorized and summarized by the number of reports of involvement in each SOC, the top 3 for oseltamivir were psychiatric disorders, gastrointestinal disorders, general disorders and site-of-administration conditions, respectively. The top 3 for baloxavir marboxil were injury, poisoning and surgical complications, general disorders and site of administration conditions, and psychiatric disorders, respectively.ConclusionOur study identifies potential new AE signals for oseltamivir and provides a broader understanding of the safety of oseltamivir and baloxavir marboxil in children.
Investigating war trauma, its effects, and associated risk factors on anxiety among high school students in Woldia town, northeast Ethiopia, 2022
Authors: Kassa Mulat Awoke , Anbesaw Tamrat , Nakie Girum , Melkam Mamaru , Azmeraw Molla , Semagn Elsabet Gezmu , Abate Biruk Beletew 
Published: July 2024

BackgroundAnxiety symptoms are the most frequent mental health problems in the world, and it is a serious public health concern, especially among adolescents, because if left untreated, adolescent anxiety can have a number of detrimental effects, including lower academic performance, strained relationships with friends and family, substance addiction, thoughts of suicide and homicide, and trouble finding work. While this vulnerability is concerning in all situations, it is particularly critical in armed conflict areas. Ethiopia is one of the most recent war-affected countries, but to the best of our knowledge, limited studies focused on adolescents in this context. Therefore, this study assessed the experience of war trauma and its effects on anxiety symptoms among high school students in Woldia town, Ethiopia.ObjectiveWe assessed the experience of war trauma and its effects on anxiety among high school students, as well as associated risk factors, in war-affected areas in Woldia town, northeast Ethiopia.MethodsA cross-sectional study design was conducted from May 23 to June 08 2022. Data were collected from high school students in Woldia town. Bivariable and multivariable logistic regression analyses were used to identify independent factors associated with anxiety.ResultsA total of 624 out of 660 students participated in the study (94.5% response rate). The prevalence of anxiety among high school students in Woldia town was 39.7%. In the multivariable analysis, having depression (AOR = 9.24, 95% CI: 6.27, 13.64), witnessing the murder of family/friends (AOR = 1.93, 95% CI: 1.05, 3.57), being of female sex (AOR=1.59, 95% CI: 1.08, 2.36), and having a family history of mental illness (AOR=1.69, 95% CI: 1.00, 2.85) were factors significantly associated with anxiety.Conclusions and recommendationsThe prevalence of anxiety in this study was approximately two in five high school students. Therefore, we recommend that the Ministry of Education collaborate with the Ministry of Health to expand and implement mental health services in high schools to promote the wellbeing of students for the prevention of anxiety.
The effects of cultural engagement on health and well-being: a systematic review
Authors: Viola Erica , Martorana Marco , Ceriotti Daniele , De Vito Marta , De Ambrosi Damiano , Faggiano Fabrizio 
Published: July 2024

PurposeThis paper examines the effectiveness of culture-based activities in improving health-related outcomes among middle-aged and older adults. Based on the biopsychosocial model, this review aims to explore the impact of cultural engagement on health and well-being.MethodsWe conducted a systematic literature review based on peer-reviewed articles retrieved from various electronic databases. In total, 11 studies were included in this review. Our study population consisted of healthy adults aged over 40 years.ResultsThe results provide evidence of positive association between cultural participation and better mental health (e.g., cognitive decline, depression, anxiety), frailty, resilience, well-being and social relations.ConclusionThis review suggests that cultural engagement serves as an effective means for individuals to maintain and enhance their health and well-being. The field is mostly limited by the heterogeneity of the studies and poor conceptualization of cultural activities. Thus, it is recommended that future research consider the effects of different cultural interventions in developing effective strategies for promoting healthy lifestyles and enhancing quality of life in later stages of life.
Community Health Volunteers’ experiences of implementing COVID-19 vaccine education and promotion in Kenya: a qualitative descriptive study
Authors: Shumba Constance S. , Kiraithe Peterson , Kambo Isabel , Shaibu Sheila 
Published: July 2024

BackgroundVaccination was a key measure in the COVID-19 pandemic response, though much work was needed to promote vaccine uptake and acceptance. In Kenya, Community Health Volunteers (CHVs) played a key role in vaccine education and promotion. We conducted this study to explore CHVs’ experiences of implementing COVID-19 vaccine education and promotion during the pandemic to increase COVID-19 vaccine uptake in two areas of Kenya.MethodsIn a qualitative descriptive study, we conducted 30 structured in-depth interviews with 20 CHVs and 10 Community Health Assistants from rural Kilifi County and Kangemi, an urban informal settlement of Nairobi County in Kenya between April 2022 and July 2022.FindingsThematic analysis generated five key themes in relation to CHVs’ experiences of implementing COVID-19 vaccine education and promotion: Five key themes emerged regarding CHVs’ experiences of implementing COVID-19 vaccine education and promotion: (1) vaccine preferences influenced acceptance, (2) the fear of side effects was a barrier, (3) misinformation was widespread (4) lack of trust in government and politicization of vaccines was a barrier, and (5) CHVs’ efforts were a facilitator to increased uptake.ConclusionExtensive community outreach from CHVs contributed to the high uptake of primary vaccines and boosters during the COVID-19 pandemic. CHVs acting as role models by receiving vaccinations first was particularly important in influencing communities to accept vaccinations. Findings provide evidence for prioritizing CHVs in the planning and implementation of future vaccination initiatives in Kenya and other countries.
Space–time distribution of intestinal infectious diseases and their association with socioeconomic variables in Ecuador
Authors: Lalangui Karina , Cotera-Mantilla Max , Sánchez-Murillo Marco , Carrera-Alvarez Alex , Duque-Cuasapaz Mónica , Quentin Emmanuelle 
Published: July 2024

BackgroundIntestinal infectious diseases are a global concern in terms of morbidity, and they are closely linked to socioeconomic variables such as quality of life, weather and access to healthcare services. Despite progress in spatial analysis tools and geographic information systems in epidemiology, studies in Ecuador that evaluate temporal trends, specific geographic groups, and their correlation with socioeconomic variables are lacking. The absence of such information makes it challenging to formulate public health policies. This study sought to identify the spatial and temporal patterns of these diseases in Ecuador, along with their correlation with socioeconomic variables.MethodsIn Ecuador, the study was carried out in a continental territory, focusing on data related to intestinal infectious diseases collected from the National Institute of Statistics and Census (Instituto Nacional de Estadística y Censos) during the period from 2014 to 2019. This study involved spatial and temporal analyses using tools such as the global Moran’s index and Local Indicators of Spatial Association to identify spatial clustering patterns and autocorrelation. Additionally, correlations between morbidity rates and socioeconomic variables were examined.ResultsDuring the investigated period, Ecuador registered 209,668 cases of these diseases. Notable variations in case numbers were identified, with a 9.2% increase in 2019 compared to the previous year. The most impacted group was children under 5 years old, and the highest rates were centered in the southern and southwestern regions of the country, with Limón Indanza and Chunchi being the cantons with the highest rates, notably showing a significant increase in Limón Indanza. Additionally, there were significant correlations between morbidity rates and socioeconomic variables, school dropout rates, low birth weight, and access to water services.ConclusionThis study emphasizes the importance of considering socioeconomic variables when addressing these diseases in Ecuador. Understanding these correlations and geospatial trends can guide the development of health policies and specific intervention programs to reduce the incidence in identified high-risk areas. More specific research is needed to understand the underlying causes of variability in morbidity and develop effective prevention strategies.
Trends in the Link Between Perceived Social Support and Life Satisfaction in Adolescents (2013/14–2021/22): A Cross-National Study
Authors: Brisson Romain , Furstova Jana , Sokolová Lenka , Eriksson Charli , Boniel-Nissim Meyran , Badura Petr 
Published: July 2024

ObjectivesThis repeated cross-sectional study aimed to (a) report trends in adolescents’ perceived family, friend, classmate, and teacher support, (b) estimate the extent to which each source of support related to life satisfaction across space and time, and (c) ascertain whether sociodemographic factors moderated the relationship in question.MethodsWe relied on data pertaining to the 2013/14, 2017/18, and 2021/22 waves of the Health Behaviour in School-aged Children study. The examined sample covered 44 countries and regions (n = 716,083; MAGE = 13.6; SDAGE = 1.64; 50.7% female).ResultsThe level of all sources of perceived social support slightly decreased over the examined period (all ω2 &lt; .01). Family support involved the largest association with life satisfaction (β = 0.16); friend support, the lowest one (β = 0.03). These associations varied only tenuously across space and time. Sociodemographic factors moderated the link between perceived social support and life satisfaction to a negligible-to-weak extent.ConclusionLevels of perceived social support and their associations with life satisfaction subtly changed. Future research may attempt to pinpoint the macrosocial levers of these temporal dynamics.
Clerodendrum trichotomum Thunberg—An Ornamental Shrub with Medical Properties
Authors: Gomulski Jan , Grzegorczyk-Karolak Izabela 
Published: July 2024

Harlequin glory bower (Clerodendrum trichotomum) is a shrub or small tree belonging to the Lamiaceae family, native to Japan, Korea, and eastern China. It has esthetic value and in Europe, it is cultivated as an ornamental plant. Its sweet-smelling flowers have a white or pink crown. The calyx turns from green to pink–purple over time, providing an especially decorative touch around surrounding the ripe deep-blue fruits that persist until winter. In the areas of its natural occurrence, the leaves and young shoots of C. trichotomum, and sometimes the roots, flowers and fruits, are used in folk medicine due to its anti-inflammatory, analgesic, anticancer, sedative, and hypotensive effects. Products based on Harlequin glory are also used in the treatment of rheumatoid arthritis, joint pain, skin inflammation, or asthma. Preliminary research on the composition of raw material suggests that its health-promoting effect is associated with the presence of numerous secondary metabolites, including phenylpropanoids, flavonoids, lignans, terpenoids, steroids, alkaloids, and anthraquinones. This work reviews the current state of knowledge about the phytochemistry and in vitro and in vivo pharmacological properties of the extracts and main active components isolated from C. trichotomum. It also indicates that before it can be used in modern medicine, further research is necessary regarding the safety and efficacy of the raw material, its mechanisms of action, and dosage.
THE INFLUENCE OF HYPERBARIC OXYGEN THERAPY ON COCHLEAR PERCEPTION IMPROVEMENT IN SUDDEN DEAFNESS: LITERATURE REVIEW
Authors: Zahira Azzeldine Aliya , EP Djati Widodo , Hisnindarsyah Hisnindarsyah , Buwana Aditya Wira , Indrawati Roostantia 
Published: July 2024

Gangguan pendengaran mendadak diketahui menjadi salah satu gangguan pendengaran yang sering terjadi dengan jumlah kasus berkisar 80% hingga 90% kasus, dan mayoritas berdampak pada gangguan pendengaran mendadak di salah satu telinga. Kasus gangguan pendengaran mendadak diketahui dapat disembuhkan melalui manajemen yang sesuai. Kelainan vaskuler, kelainan imunologi, infeksi akibat virus serta rusaknya membran koklea dinilai sebagai faktor penyebab gangguan pendengaran. Salah satu manajemen gangguan pendengaran mendadak yang sering dilakukan dalam jangka waktu pendek adalah terapi oksigen hiperbarik. Terapi oksigen hiperbarik pada pasien gangguan pendengaran mendadak sebagai salah satu manajemen penanganan gangguan pendengaran mendadak bekerja melalui mekanisme peningkatan distribusi oksigen pada koklea. Penelitian ini disusun dengan tinjauan literatur sistematis untuk mengevaluasi pengaruh terapi oksigen hiperbarik terhadap perbaikan gangguan pendengaran mendadak. Peneliti memilih sampel dari jurnal internasional dan nasional yang terindeks oleh ProQuest, Wiley Online, Science Direct, Taylor Francis, SAGE, PubMed, dan SINTA antara tahun 2017 dan 2022. Peneliti menyadari kurangnya literatur yang relevan karena hanya 11 jurnal yang sesuai dengan kriteria penelitian. Namun, ini dianggap sebagai langkah awal untuk penelitian lebih lanjut. Temuan menunjukkan bahwa terapi oksigen hiperbarik berpengaruh terhadap perbaikan persepsi koklea pada pasien yang mengalami gangguan pendengaran mendadak, setelah pemberian terapi dengan rata-rata waktu 1-2 minggu, dengan tekanan 1,8 ATA hingga 2 ATA, baik dikombinasikan dengan kortikosteroid maupun terapi oksigen hiperbarik saja. Rekomendasi penulis adalah penelitian selanjutnya dapat meneliti faktor yang memengaruhi efektivitas pemberian terapi oksigen hiperbarik terhadap perbaikan gangguan pendengaran mendadak serta pemberian terapi oksigen hiperbarik dapat menjadi salah satu terapi adjuvan yang dapat diberikan kepada pasien di Indonesia.
Design of Cybersecurity Maturity Assessment Framework Using NIST CSF v1.1 and CIS Controls v8
Authors: Irawan Hafizhan , Muhammad Alva Hendi , Nasiri Asro 
Published: July 2024

Cybersecurity threats are constantly evolving, making it crucial for organizations to maintain a robust and maturing cybersecurity posture. According to the 2022 Annual Report of the Honeynet Project of the National Cyber and Crypto Agency (BSSN), there were 370,022,283 cyber attacks against Indonesia.Â Â One of the strategies that can be implemented is to conduct a cybersecurity maturity assessment to determine the organization's current level of cybersecurity implementation. This paper proposes a design for a cybersecurity maturity assessment framework leveraging two established standards: the National Institute of Standards and Technology (NIST) Cybersecurity Framework (CSF) v1.1 and the Center for Internet Security (CIS) Controls v8. The proposed framework utilizes a mapping between the NIST CSF v.1.1 subcategories and the CIS Controls v8 subcontrols, enabling a comprehensive assessment of an organization's cybersecurity maturity. The assessment methodology focuses on evaluating the implementation and effectiveness of controls aligned with each NIST CSF function. This approach allows organizations to identify strengths and weaknesses in their cybersecurity posture and prioritize areas for improvement. This research developed a mapping between the NIST CSF framework and CIS Controls v8. The mapping aligns 23 integrated cybersecurity categories from NIST CSF (including 64 subcategories out of a possible 108) with 124 subcontrols from CIS Controls v8 (out of a total 153). This combined framework serves as a tool to help organizations improve their cybersecurity maturity and capabilities.
Designing a PMRI Electronic Pocketbook for Enhanced Algebra Conceptual Understanding and Learning Interest in Junior High School Students
Authors: Fitriani Atikah , Jailani Jailani 
Published: July 2024

This study aims to produce PMRI (the Indonesian version of realistic mathematics education) electronic pocketbooks oriented to the ability to understand concepts and student learning interests with algebra material for seventh-grade students that meet the criteria of valid, practical, effective, and feasible to use in the learning process. This research is development research using the ADDIE development model, namely analysis, design, development, implementation, and evaluation. The research subjects were 32 students of class VII E, conducted at one of Junior High School in Yogyakarta. Data collection techniques are tests and questionnaires. The results showed that the media met the valid criteria with a very valid category, met the practical criteria with a very practical category, and effective criteria with a very effective category. It can be concluded that the PMRI electronic pocketbook oriented to the concept of understanding the ability and learning interests of junior high school students meets the criteria of valid, practical, effective, and feasible to use for learning. Thus, PMRI electronic pocketbook could potentially revolutionize math education by catering to individual learning styles, fostering deeper understanding, and enhancing overall academic performance among junior high school students.