bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astrocytes facilitate gabazine‐evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures
Authors: Ahtiainen Annika , Genocchi Barbara , Subramaniyam Narayan Puthanmadam , Tanskanen Jarno M. A. , Rantamäki Tomi , Hyttinen Jari A. K. 
Published: July 2024

AbstractGamma‐aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the adult brain that binds to GABA receptors and hyperpolarizes the postsynaptic neuron. Gabazine acts as a competitive antagonist to type A GABA receptors (GABAAR), thereby causing diminished neuronal hyperpolarization and GABAAR‐mediated inhibition. However, the biochemical effects and the potential regulatory role of astrocytes in this process remain poorly understood. To address this, we investigated the neuronal responses of gabazine in rat cortical cultures containing varying ratios of neurons and astrocytes. Electrophysiological characterization was performed utilizing microelectrode arrays (MEAs) with topologically controlled microcircuit cultures that enabled control of neuronal network growth. Biochemical analysis of the cultures was performed using traditional dissociated cultures on coverslips. Our study indicates that, upon gabazine stimulation, astrocyte‐rich neuronal cultures exhibit elevated electrophysiological activity and tyrosine phosphorylation of tropomyosin receptor kinase B (TrkB; receptor for brain‐derived neurotrophic factor), along with distinct cytokine secretion profiles. Notably, neurons lacking proper astrocytic support were found to experience synapse loss and decreased mitogen‐activated protein kinase (MAPK) phosphorylation. Furthermore, astrocytes contributed to neuronal viability, morphology, vascular endothelial growth factor (VEGF) secretion, and overall neuronal network functionality, highlighting the multifunctional role of astrocytes.image
Complications and putative risk factors for cecal or colonic surgery in dogs: 79 cases (2002‐2015)
Authors: James J. C. , O'Neill S. , Moore G. E. , Scotti K. M. , Perry K. L. , Sterman A. A. 
Published: July 2024

ObjectivesTo evaluate the complication rate, mortality rate and putative risk factors for cecal or colonic surgery in dogs.Materials and MethodsA multi‐institutional retrospective study including dogs that had undergone surgery that involved the cecum or the colon. Medical records from three referral hospitals were reviewed for patient demographics and clinical data. The association between putative risk factors and survival to discharge or complications was assessed using univariable and multivariable analysis.ResultsSeventy‐nine dogs met the criteria to be included in this study. Fifty‐five dogs had full thickness incision surgeries, while 24 dogs had partial thickness surgeries. The complication and mortality rates for full thickness and partial thickness cecal/colonic surgeries were not statistically different. The dehiscence rate of colonic anastomosis in this study was four of 47 (8.5%). On univariate analysis, performing full thickness procedures out of hours had an association with increased complications and mortality. On multivariable analysis, no factors were associated with survival to discharge or complications. There was no association of board‐certified surgeon presence in surgery with complications or mortality.Clinical SignificanceThe performance of full thickness cecal/colonic surgery is not associated with a statistically significant increased risk for complications or mortality compared to partial thickness procedures, with a possible increased risk of complications and mortality in full thickness procedures out of hours.
ZMFISC: Zhu‐Ming data set with a convolutional neural network for identifying Indo‐Pacific humpback dolphins (Sousa chinensis)
Authors: Yang Minghao , Wu Zhongrui , Zang Xiqing , Jin Changlong , Zhu Qian 
Published: July 2024

AbstractThe Indo‐Pacific humpback dolphin (Sousa chinensis) is a small‐toothed whale species that inhabits estuaries and shallow coastal waters from the eastern Indian Ocean to the western Pacific, and faces significant negative impacts from anthropogenic activities. The noninvasive Photo‐identification method enables individual identification and abundance estimation based on natural markings of cetaceans without disrupting their natural behaviors. Currently, the identification of S. chinensis using photographs relies primarily on time‐intensive visual recognition by experienced researchers. Through field surveys conducted in the west Huangmao Sea area from 2012 to 2021, we compiled the Zhu‐Ming data set focusing on S. chinensis (ZMSC), consisting of 479 individuals and 5,196 photos. Utilizing the ZMSC, we proposed a Few‐Shot Identification method for S. chinensis (FISC), which achieved 85.93% identification Top‐1 accuracy. The implementation of proper preprocessing steps and data augmentation techniques has significantly enhanced the performance of FISC, while visualizing network weights has improved its interpretability. Despite the remaining challenges of data imbalance and the inability to automatically allocate new labels, ZMFISC alleviates the challenge of the current heavy reliance on time‐intensive visual recognition methods by researchers for individual identification of S. chinensis and provide a valuable tool to enhance future conservation efforts for S. chinensis.
Distribution of Arnoux's beaked whales (Berardius arnuxii)
Authors: Feij Bram , Kühn Susanne , Meijboom André , van Franeker Jan A. , Bornemann Horst , Kelly Nat , Schaafsma Fokje L. 
Published: July 2024

AbstractArnoux's beaked whales (Berardius arnuxii) are generally considered to be uncommon to rare, and likely to prefer deep oceanic waters of the Southern Hemisphere. During many top‐predator surveys in the Southern Ocean since 1988 we did not sight the species. However, in April 2022 we encountered three groups in the marginal sea‐ice zone of the Weddell Sea. This study provides detailed descriptions of the sighted animals and their environment and report on unpublished sightings of this species from 1986 to 1998. A search of published information on the distribution of the species revealed 108 documented sightings with a total of 1,125 individuals. In combination these sources of information for the Southern Ocean, suggest a frequent occurrence in ice‐covered waters, often close to the continental coast and edges of fast ice and ice‐shelves. North of 60°S, in the temperate regions of the Southern Hemisphere, the species was also regularly sighted near continents, even far inshore, in fjords surrounded by land.
Cultural humility in international relationship research: Perspectives from an International Section Peer Mentor
Authors: Alvarez Cimmiaron F. 
Published: July 2024

AbstractPersonal Relationships is dedicated to publishing international scholarship. Scholars can submit their work to the International Section if their manuscript reports on data that were collected outside of North America or they examine cross‐cultural investigations. For the last 2 years, I have had the privilege of being an International Section Peer Mentor for Personal Relationships. Working with international scholars conducting international research introduced me to the concept of cultural humility. Cultural humility is a perspective for intercultural interactions that embrace lifelong learning, self‐evaluation, and critique to redress power imbalances. In this commentary, I discuss my experiences as a peer mentor, introduce the concept of cultural humility, and explain lessons that I have learned.
Modified by the Innovative Drugs and Strategies—Pattern of Selected Indications for Pediatric Liver Transplantation
Authors: Jankowska Irena , Socha Piotr , Gliwicz Dorota , Lipiński Patryk , Rokicki Dariusz , Kaliciński Piotr , Danielewska Ewa , Grenda Ryszard 
Published: July 2024

ABSTRACTBackgroundLiver transplantation (LTx) constitutes a major life‐saving routine treatment for children with end‐stage liver disease. However, the analysis of LTx registries in children provides much information about changes in the indication profiles in the recent years.MethodsThe article provides a comprehensive review about the successes, hopes, and challenges related to changing indications for LTx in children based on the literature review and our own experience. Retrospective review of the indications for LTx at a tertiary referral pediatric hospital was also presented.Results and ConclusionsIn the context of the new therapies that have emerged, the need for LTx has decreased in patients with chronic hepatitis B and C infection and tyrosinemia type 1. In primary hyperoxaluria type 1, new RNAi‐based therapy has eliminated the requirement for LTx (both isolated or combined). There is a hope that introduction of ileal bile acid transporter (IBAT) blockers reduces the need for LTx in patients with Alagille syndrome or progressive familial intrahepatic cholestasis. The number of children qualified for LTx with urea cycle disorders (UCDs) as a prophylaxis of neurodevelopmental impairment is increasing.
Unraveling the temporal interplay of slow‐paced breathing and prefrontal transcranial direct current stimulation on cardiac indices of autonomic activity
Authors: Li Zefeng , Schoonjans Emmanuelle , Allaert Jens , De Smet Stefanie , Kappen Mitchel , Houfflyn Joni , Ottaviani Cristina , De Raedt Rudi , Pulopulos Matias M. , Vanderhasselt Marie‐Anne 
Published: July 2024

AbstractThe neurovisceral integration model proposes that information flows bidirectionally between the brain and the heart via the vagus nerve, indexed by vagally mediated heart rate variability (vmHRV). Voluntary reduction in breathing rate (slow‐paced breathing, SPB, 5.5 Breathing Per Minute (BPM)) can enhance vmHRV. Additionally, prefrontal transcranial direct current stimulation (tDCS) can modulate the excitability of the prefrontal region and influence the vagus nerve. However, research on the combination of SPB and prefrontal tDCS to increase vmHRV and other cardiac (heart rate (HR) and blood pressure) and peripheral (skin conductance) indices is scarce. We hypothesized that the combination of 20 min of SPB and prefrontal tDCS would have a greater effect than each intervention in isolation. Hence, 200 participants were divided into four groups: active tDCS with SPB, active tDCS with 15 BPM breathing, sham tDCS with SPB, and sham tDCS with 15 BPM breathing. Regardless of the tDCS condition, the 5.5 BPM group showed a significant increase in vmHRV over 20 minutes and significant decreases in HR at the first and second 5‐min epochs of the intervention. Regardless of breathing condition, the active tDCS group exhibited higher HR at the fourth 5‐min epoch of the intervention than the sham tDCS group. No other effects were observed. Overall, SPB is a robust technique for increasing vmHRV, whereas prefrontal tDCS may produce effects that counteract those of SPB. More research is necessary to test whether and how SPB and neuromodulation approaches can be combined to improve cardiac vagal tone.
The property of goal‐directedness: Lessons from the dispositions debate
Authors: Tugby Matthew 
Published: July 2024

AbstractThe system‐property or ‘cybernetic’ theory of goals and goal‐directedness became popular in the twentieth century. It is a theory that has reductionist and behaviourist roots. There are reasons to think that the system‐property theory needs to be formulated in terms of counterfactuals. However, it proves to be difficult to formulate a counterfactual analysis of goal‐directedness that is counterexample‐free, non‐circular, and non‐trivial. These difficulties closely mirror those facing reductionists about dispositions, though the parallels between the two debates have been overlooked in the literature. After outlining those parallels, the paper considers what goal theorists might learn from the dispositions debate. In particular, the paper discusses the need for a realist, non‐reductionist account of goal‐directedness, and explores the idea that properties of goal‐directedness are themselves dispositions or ‘powers’ of a certain sort.
Meaning‐oriented thematic analysis grounded in reflective lifeworld research—A holistic approach for caring science research
Authors: Lindberg Elisabeth , Palmér Lina , Hörberg Ulrica 
Published: July 2024

AbstractBackground and AimThe aim of the present article is to describe meaning‐oriented thematic analysis grounded in reflective lifeworld research and to illustrate how the thematic analysis can be integrated in the research process. The article is a methodological paper, including ontological and epistemological assumptions for lifeworld theory. Research based on lifeworld theory is directed towards lived experiences and meanings in everyday life. Research that is founded on the epistemology of the lifeworld can present existential issues important for caring and qualitative research can in particular contribute to existential knowledge needed to understand the world of the patient.DesignTheoretical paper.ResultsStarting with a phenomenon of relevance for caring science, the article argues for lifeworld interviews as a data collection method that can contribute to depth and meaning, and then presents a description of how structures of meaning can be outlined through a meaning‐oriented thematic analysis. The research of lived experiences in caring science demands an approach that includes a reflective attitude during the methodological considerations. This article highlights the importance of ontological and epistemological considerations when conducting a meaning‐oriented thematic analysis.ConclusionThe article places meaning‐oriented thematic analysis in a wider research process, considering all aspects from collection of data to the creation of meaning‐oriented themes.
Hydraulic reconstruction of giant paleolandslide‐dammed lake outburst floods in high‐mountain region, eastern Tibetan Plateau: A case study of the Upper Minjiang River valley
Authors: Ma Junxue , Chen Jian , Xu Chong 
Published: July 2024

AbstractLandslide‐dammed lakes are potentially hazardous and catastrophic for their possible failures and outburst floods (OFs) that will cause disastrous damage and life‐threatening losses, especially in the alpine areas where seismicity is strong and frequent, such as the eastern margin of the Tibetan Plateau. This study focused on spreading an effective numerical model to reconstruct downstream hazards induced by a giant ancient landslide‐dammed lake outburst flood (LLOF) in the upper Minjiang River valley, eastern Tibetan Plateau based on the integration of the hydraulic characteristics of the upstream dammed lake, dam failure and erosion process, and downstream OF dynamics. The peak discharge levels and paleohydraulics of the LLOF were reconstructed using single‐embankment dam‐break program and one‐dimensional steady hydraulic numerical model. The results reveal that the maximum peak discharge of the Diexi paleo LLOF was 73,060–82,235 m3/s, with an uncertainty bound of 73,000–90,000 m3/s (mean value: 81,500 m3/s). Which inferred that the Diexi paleo LLOF was one of the largest known LLOFs in the view of worldwide scope comparing with other types of floods. Then, the hydraulic characteristics and route evolution of the LLOF were simulated in one‐dimensional unsteady numerical model. The results showed that the Diexi paleo LLOF took 7.47 h to transport from Diexi to Wenchuan within the simulated section of 91.23 km, with an average propagation velocity of 3.39 m/s. At the time of 15.57 h, the simulating section (between Diexi and Wenchuan) reached the maximum extent of inundation which was 664.91 km2, with an average value of 7.29 km2/km. Our modeling supports that the numerical model can be used successfully to reconstruct the hydraulics of a paleo LLOF in deep confined gorge environment. The reconstructed paleo LLOF data are of great significance to enrich the regional megaflood records and provide valuable information for geological hazard controls and OF risk assessment within the upper catchment of Minjiang River at the eastern margin of the Tibetan Plateau.
Brow rhytidectomy with or without Stades‐like procedure for correction of pseudoptosis and trichiasis‐entropion of the upper eyelid in Chow Chow and Shar‐Pei dogs: A retrospective study of 27 dogs (2019–2022)
Authors: Sarfaty Havi , Ezra‐Elia Raaya , Kahane Nili , Sandalon Shai , Segev Yifat , Sebbag Lionel 
Published: July 2024

AbstractPurposeHeavy brows in Chow Chow and Shar‐Pei dogs can be associated with pseudoptosis and trichiasis‐entropion of the upper eyelids, causing vision impairment and ocular discomfort. This study describes the outcomes of brow rhytidectomy ± Stades‐like procedure to address these anatomical abnormalities.MethodsRetrospective medical records review (2019–2022).ResultsTwenty‐seven dogs (n = 15 Chow Chow, n = 12 Shar‐Peis) were included, aged 1.9 ± 1.5 years (0.5–6.5 years). Presenting complaints included recurrent episodes of ocular inflammation (n = 13, 48.1%), blepharospasm (n = 10, 37.0%), corneal ulcers (n = 8, 29.6%), entropion (n = 6, 22.2%), and impaired vision (n = 4, 14.8%). Brow skin was removed as follows: (i) First incision parallel and 10–15 mm dorsal to upper lid, slightly extending beyond medial/lateral canthi; (ii) second incision forming an arc with its apex 15–35 mm dorsal to the first incision; and (iii) standard two or three layers closure. In 22/27 dogs, a Stades‐like procedure was performed by removing a 2–4 mm strip of skin above eyelid margin and leaving it to heal by secondary intention (no sutures). At last recheck (follow‐up 354.5 ± 187.8 days), 19/27 dogs (70.4%) had an adequate eyelid conformation, 7/27 dogs (25.9%) were considered under‐corrected, and 1/27 dogs (3.7%) was over‐corrected. Most owners (81.5%) were satisfied with the surgical results. Most cases (96.3%) had no recurrence of the clinical signs during the entire follow‐up period.ConclusionsBrow rhytidectomy ± Stades‐like procedure provide good cosmetic and clinical outcomes in Chow Chow and Shar‐Pei dogs, although under correction may occur in severely affected dogs and with advancing time.
Induction of the PERK-eIF2α-ATF4 Pathway in M1 Macrophages under Endoplasmic Reticulum Stress
Authors: Kolodeeva O. E. , Kolodeeva O. E. , Averinskaya D. A. , Makarova Yu. A. 
Published: July 2024

Abstract
Translation inhibition can activate two cell death pathways. The first pathway is activated by translational aberrations, the second by endoplasmic reticulum (ER) stress. In this work, the effect of ribosome-inactivating protein type II (RIP-II) viscumin on M1 macrophages derived from the THP-1 cell line was investigated. The number of modified ribosomes was evaluated by real-time PCR. Transcriptome analysis revealed that viscumin induces the ER stress activated by the PERK sensor.
Cost-effectiveness analysis of rezvilutamide versus bicalutamide in the treatment of metastatic hormone-sensitive prostate cancer
Authors: Ding Haiying , Li Shujing , Xu Xinglu , Xu Weiben , He Chaoneng , Xin Wenxiu , Zhan ZhaJun , Fang Luo 
Published: July 2024

ObjectivesThe economic implications of combining rezvilutamide with androgen deprivation therapy (ADT) remain uncertain, despite the observed survival advantages compared with bicalutamide plus ADT. Therefore, this study evaluates the cost-effectiveness of rezvilutamide plus ADT as the first-line treatment of metastatic hormone-sensitive prostate cancer (mHSPC) from the perspective of the Chinese healthcare system.DesignA partitioned survival model was developed to assess the cost-effectiveness of rezvilutamide combined with ADT. Clinical data were obtained from the CHART trial. Costs and utility values were obtained from local estimate and published literature. Only direct medical costs were included in the model.InterventionsRezvilutamide was administered at 240 mg daily or bicalutamide at 50 mg daily until progression.Outcome measuresThe main outputs of the model included costs and quality-adjusted life years (QALYs), which were used to determine the incremental cost-effectiveness ratio (ICER). One-way and probabilistic sensitivity analysis (PSA) were used to explore model uncertainties.ResultsThe rezvilutamide group showed an expected gain of 2.28 QALYs and an incremental cost of US$60 758.82 compared with the bicalutamide group. The ICER for rezvilutamide group versus bicalutamide group was US$26 656.94 per QALY. The variables with the greatest impact on the model results were the utility for progression-free survival state and the price of rezvilutamide. PSA revealed that rezvilutamide group had 100% probability of being cost-effective at a willingness-to-pay threshold of US$35707.5 per QALY.ConclusionRezvilutamide in combination with ADT is more cost-effective compared with bicalutamide plus ADT as the first-line treatment of mHSPC from the perspective of the Chinese healthcare system.
Demographic, socioeconomic and health determinants of depressive symptoms in adults 50 years and older from Mexico: a secondary data longitudinal analysis from the Mexican Health and Aging Study
Authors: Giraldo-Rodríguez Liliana , Torres-Castro Sara , Roa-Rojas Paloma Arlet , Alvarez-Cisneros Teresa 
Published: July 2024

AbstractBackgroundDepression in ageing adults is a public health problem. Worldwide studies have identified social and health risk factors for depressive symptoms. However, little is known about their longitudinal determinants in Mexico.Objectives and settingTo find the prevalence of depressive symptoms and their longitudinal individual and contextual risk factors in Mexican adults aged 50 and older.DesignSecondary data of 6460 persons aged 50 years and older from the Mexican Health and Aging Study were analysed using a ‘between-within’ panel data analysis approach.ResultsThe prevalence of depressive symptoms increased from 35% in 2003 to 38% in 2015. The significantly longitudinal factors associated with these symptoms were getting older (OR 1.02, 95% CI 1.01 to 1.03), being a woman (OR 2.39, 95% CI 2.16 to 2.64), less time spent in formal education (0 years and less than 6 years OR 1.52, 95% CI 1.32 to 1.75 and OR 1.33, 95% CI 1.19 to 1.50, respectively), lower net worth (OR 1.13, 95% CI 1.08 to 1.17), being recently unemployed (OR 1.25, 95% CI 1.10 to 1.25), increased (OR 1.17, 95% CI 1.10 to 1.25) or increasing number (OR 1.23, 95% CI 1.15 to 1.31) of chronic conditions, poor (OR 4.68, 95% CI 4.26 to 5.15) or worsened (OR 1.71, 95% CI 1.61 to 1.81) self-rated health and having impairments on instrumental activities of daily living (IADLs) (OR 2.94 95% CI 2.35 to 3.67) or a new IADL impairment (OR 1.67, 95% CI 1.48 to 1.89), as well as having impairments on ADLs (OR 1.51, 95% CI 1.23 to 1.86) or a new ADL impairment (OR 1.34, 95% CI 1.21 to 1.48).ConclusionsThe prevalence of depressive symptoms in Mexican adults aged 50 and older is high. Our findings show that they are longitudinally associated with the individual’s demographic, socioeconomic, health and disability characteristics. Efforts in public policy should focus on preventing chronic conditions and disability, as well as fighting inequalities to reduce the prevalence of depressive symptoms.