bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-gap esophageal atresia: is native esophagus preservation always possible?
Authors: Treccarichi G. M. , Di Benedetto V. , Loria G. , Scuderi M. G. 
Published: August 2024

IntroductionEsophageal atresia (EA) is a congenital defect that causes esophageal discontinuity, often with an associated tracheo-esophageal fistula (TEF) in 70%–90% of cases. When the distance between esophageal ends precludes primary anastomosis, it results in long gap esophageal atresia (LGEA), complicating the surgical management. This study retrospectively reviewed LGEA cases from the past decade, treated with the goal of preserving the native esophagus, comparing surgical techniques and outcomes with current literature.Materials and methodsThe data of patients treated for LGEA between 2013 and 2024 were collected from medical charts, focusing on patients treated with the preservation of their native esophagus.ResultsTen patients were enrolled for this study. All of them had a gap between the esophageal ends equal to or greater than three vertebral bodies. Four patients (40%) underwent a delayed primary anastomosis (DPA) procedure, while the remaining six (60%) underwent a traction staged repair. All patients were treated with open surgery. The follow-up period extended from 3 months to 10 years.ConclusionPreserving the native esophagus in patients with LGEA is a challenging but feasible goal, with delayed primary anastomosis and traction techniques playing key roles. We advocate for the preservation of the native esophagus as the preferred approach for ensuring a high quality of life for patients, as it helps to avoid severe long-term complications associated with esophageal substitution.
Repurposing antihypertensive drugs for pain disorders: a drug-target mendelian randomization study
Authors: Du Kai , Li Ao , Zhang Chen-Yu , Li Shu-Ming , Chen Ping 
Published: August 2024

ObjectiveAddressing the rising prevalence of pain disorders and limitations of current analgesics, our study explores repurposing antihypertensive drugs for pain management, inspired by the link between hypertension and pain. We leverage a drug-target Mendelian Randomization (MR) approach to explore their dual benefits and establish causal connections.MethodsA comprehensive compilation of antihypertensive drug classes was undertaken through British National Formulary, with their target genes identified using the DrugBank database. Relevant single nucleotide polymorphisms (SNPs) associated with these targets were selected from published genomic studies on systolic blood pressure (SBP) as genetic instruments. These SNPs were validated through MR against acute coronary artery disease (CAD) to ensure genes not linked to CAD were excluded from acting as proxies for antihypertensive drugs. An MR analysis of 29 pain-related outcomes was conducted using the FinnGen R10 database employing the selected and validated genetic instruments. We utilized the Inverse Variance Weighted (IVW) method for primary analysis, applying Bonferroni correction to control type I error. IVW’s multiplicative random effects (MRE) addressed heterogeneity, and MR-PRESSO managed pleiotropy, ensuring accurate causal inference.ResultsOur analysis differentiates strong and suggestive evidence in linking antihypertensive drugs to pain disorder risks. Strong evidence was found for adrenergic neuron blockers increasing migraine without aura risk, loop diuretics reducing panniculitis, and vasodilator antihypertensives lowering limb pain risk. Suggestive evidence suggests alpha-adrenoceptor blockers might increase migraine risk, while beta-adrenoceptor blockers could lower radiculopathy risk. Adrenergic neuron blockers also show a potential protective effect against coxarthrosis (hip osteoarthritis) and increased femgenpain risk (pain and other conditions related to female genital organs and menstrual cycle). Additionally, suggestive links were found between vasodilator antihypertensives and reduced radiculopathy risk, and both alpha-adrenoceptor blockers and renin inhibitors possibly decreasing dorsalgianas risk (unspecified dorsalgia). These findings highlight the intricate effects of antihypertensive drugs on pain disorders, underlining the need for further research.ConclusionThe findings indicate that antihypertensive medications may exert varied effects on pain management, suggesting a repurposing potential for treating specific pain disorders. The results advocate for further research to confirm these associations and to explore underlying mechanisms, to optimize pain management practices.
Bacterial chondronecrosis with osteomyelitis lameness in broiler chickens and its implications for welfare, meat safety, and quality: a review
Authors: Anthney Amanda , Do Anh Dang Trieu , Alrubaye Adnan A. K. 
Published: August 2024

The exponential increase in global population continues to present an ongoing challenge for livestock producers worldwide to consistently provide a safe, high-quality, and affordable source of protein for consumers. In the last 50 years, the poultry industry has spearheaded this effort thanks to focused genetic and genomic selection for feed-efficient, high-yielding broilers. However, such intense selection for productive traits, along with conventional industry farming practices, has also presented the industry with a myriad of serious issues that negatively impacted animal health, welfare, and productivity–such as woody breast and virulent diseases commonly associated with poultry farming. Bacterial chondronecrosis with osteomyelitis (BCO) lameness is one such issue, having rapidly become a key issue affecting the poultry industry with serious impacts on broiler welfare, meat quality, production, food safety, and economic losses since its discovery in 1972. This review focuses on hallmark clinical symptoms, diagnosis, etiology, and impact of BCO lameness on key issues facing the poultry industry.
The predation relationship between online medical search and online medical consultation—empirical research based on Baidu platform data
Authors: Wang Yang , Ran Lingshi , Jiao Wei , Xia Yixue , Lan Yuexin 
Published: August 2024

IntroductionThis study investigates the mutual influence between online medical search and online medical consultation. It focuses on understanding the health information needs that drive these health information-seeking behaviors by utilizing insights from behavioral big data.MethodsWe used actual behavioral data from Chinese internet users on Baidu platform’s “Epidemic Index” from November 26, 2022, to January 25, 2023. Data modeling was conducted to ensure the reliability of the model. Drawing on the logistic model, we constructed a foundational model to quantify the evolutionary patterns of online medical search and online medical consultation. An impact function was defined to measure their mutual influence. Additionally, a pattern detection experiment was conducted to determine the structure of the impact function with maximum commonality through data fitting.ResultsThe analysis allowed us to build a mathematical model that quantifies the nonlinear correlation between online medical search and online medical consultation. Numerical analysis revealed a predation mechanism between online medical consultation and online medical search, highlighting the role of health information needs in this dynamic.DiscussionThis study offers a novel practical approach to better meet the public’s health information needs by understanding the interplay between online medical search and consultation. Additionally, the modeling method used here is broadly applicable, providing a framework for quantifying nonlinear correlations among different behaviors when appropriate data is available.
Impact of Urban-Rural Resident Basic Medical Insurance integration on individual social fairness perceptions: evidence from rural China
Authors: Liu Dandan , Chu Yifei 
Published: August 2024

BackgroundAchieving universal health insurance coverage has become a fundamental policy for improving the accessibility and equity of healthcare services. China's Urban-Rural Resident Basic Medical Insurance (URRBMI) is a crucial component of the social security system, aimed at promoting social equity and enhancing public welfare. However, the effectiveness of this policy in improving rural residents' social fairness perceptions (SFP) remains to be tested.ObjectiveTo examine the impact of the urban-rural resident basic medical insurance (URRBMI) on rural residents' social fairness perception (SFP) in China.Methods and samplesThe study utilizes city-level and national micro-survey (CGSS) datasets, applying a time-varying difference-in-difference (DID) approach to analyze the equity effects of URRBMI. Excluding urban samples, the final dataset consists of 20,800 rural respondents from 2010, 2011, 2013, and 2015, covering 89 cities.ResultsKey findings reveal that URRBMI has a significant negative effect on SFP. The impact varies depending on the integration model and intensifies over time. Additionally, the negative effect shows heterogeneity based on income, age, health, and region.ConclusionThis study highlights the complexities and impacts of integrating China's urban and rural healthcare systems. It provides a detailed understanding of the role of URRBMI in rural China, emphasizing the need for targeted approaches to improve rural residents' perceptions of social fairness. The research offers specific policy recommendations, such as establishing differentiated contribution standards, implementing welfare policies favoring rural residents, and adopting varied reimbursement rates for different diseases.
Enhancing broiler product consumption: the influence of consumer perceptions and information delivery—evidence from five Chinese provinces
Authors: Lin Huiqi , Zhu Chengfei , Yang Haopeng , He Jun 
Published: August 2024

IntroductionGiven the advantages of broiler products in quality, nutritional value, and environmental benefits, as well as their crucial role in China’s food security, this study focuses on strategies to enhance their consumption. A major constraint to consumption growth is the lack of consumer awareness. This study investigates how information delivery influences consumer perceptions, aiming to promote consumption growth and achieve sustainable development in the broiler industry.MethodsA scenario experiment approach was used, recruiting 416 consumers across five provinces. Twelve messaging strategies were developed to evaluate their impact on consumer perceptions, considering both the source and type of information provided.ResultsThe experiment revealed that both the credibility of the information source and the nature of the content significantly influenced consumer perceptions. Information from credible sources and positive content notably enhanced perceptions. Analytical information had a more substantial impact than conclusive information, while negative information adversely affected perceptions.DiscussionThe study recommends optimizing information dissemination strategies and using highly trusted platforms to deliver positive analytical information about broiler products. This approach aims to enhance consumer perceptions and stimulate consumption. The findings provide an empirical foundation for industry practitioners and policymakers to better understand consumer behavior and develop effective marketing and education strategies, supporting the sustainable development of the broiler industry and optimizing China’s meat consumption structure while ensuring food security.
Effect of potential risk factors on renal functions in simultaneous bilateral total knee arthroplasty
Authors: Akar Bedrettin , Ugur Fatih , Yucel Mucahid Osman , Aytug Ferhan 
Published: August 2024

ObjectiveThis retrospective study investigated the risk factors leading to a decrease in Renal glomerular filtration rate (eGFR) and the development of acute kidney injury (AKI) during the early postoperative period in patients undergoing simultaneous bilateral total knee arthroplasty (SBTKA).MethodsSBTKA was performed on 862 patients between 2014 and 2021 in a single center, by a single surgeon. The risk factors affecting the development of AKI were analyzed by monitoring the changes in pre-and postoperative serum creatinine (Scr) levels and eGFR values. RIFLE criteria were used to evaluate the kidney functions of the patients, who were followed up for an average of 6 months.ResultsWhile there was no decrease in eGFR or AKI in 818 patients postoperatively, eGFR decreased and AKI of different stages developed in 44 patients, according to the RIFLE criteria. Of the 44 patients with AKI, 31 had Risk, 9 had Injury, 3 had Failure, and one had Loss of kidney function. Two patients with American Society of Anaesthesiologists (ASA) class IV died due to deepening of postoperative renal dysfunction.ConclusionWe found that the direct risk factors in SBTKA in terms of eGFR decrease and AKI development include long operation time, increased need for blood transfusion, and diabetic nephropathy, while increased body mass index (BMI) is an indirect risk factor. When planning for a SBTKA, we presume that a thorough analysis of these factors will decrease AKI risk.
TALENT POOL MANAGEMENT OF THE UNIVERSITY COMPLEX: METHODOLOGY FOR ANALYZING THE NEED FOR MANAGEMENT PERSONNEL
Authors: Александрова Н.А. 
Published: August 2024

Значительное число организаций, заботящихся о сохранении и упрочении своих позиций на соответствующих рынках, радеют о преемственности курса, непрерывности и целостности управленческого процесса. Для реализации этой задачи компании разрабатывают программы формирования и развития кадрового резерва, которые являются неотъемлемой частью общей и кадровой стратегии. Образовательные организации высшего образования (университетские комплексы), учредителем которых является Федеральное агентство железнодорожного транспорта, работают на остроконкурентном рынке образовательных услуг. Поскольку основным работодателем для выпускников транспортных вузов являются структуры ОАО «РЖД», руководство холдинга заинтересовано в повышении качества менеджмента образовательных организаций за счет сохранения апробированных и внедрения новых управленческих практик, что способствует поддержанию и развитию профессионального потенциала отрасли. Настоящая статья является первой из трех публикаций, посвященных вопросу организации работы по управлению кадровым резервом университетов путей сообщения. В ней представлена методика анализа потребности образовательной организации в управленческих кадрах на перспективу от 3 до 5 лет, основанная на прогнозе развития основных направлений ее деятельности и изменения ее организационной и управленческой структур и определении конкретной должностной структуры кадрового резерва.
A significant number of organizations that care about maintaining and strengthening their positions in the relevant markets care about the continuity of the course, continuity and integrity of the management process. To achieve this task, companies are developing programs for the formation and development of a personnel reserve, which are an integral part of the overall and personnel strategy. Educational organizations of higher education (university complexes), the founder of which is the Federal Agency for Railway Transport, operate in the highly competitive market of educational services. Since the main employer for graduates of transport universities are the structures of JSC Russian Railways, the holding’s management is interested in improving the quality of management of educational organizations by preserving proven and introducing new management practices, which helps maintain and develop the professional potential of the industry. This article is the first of three publications devoted to the issue of organizing work on managing the personnel reserve of railway universities. It presents a methodology for analyzing the needs of an educational organization for management personnel for a period of 3 to 5 years, based on the forecast of the development of the main directions of its activities and changes in its organizational and management structures and the determination of the specific job structure of the personnel reserve.
Formación docente y territorio en Colombia: Subjetividades, singularidades y diferencias
Authors: Zora Luis F. Vásquez , Silva Geovani de Jesus da , Bomfim Natanael Reis 
Published: August 2024

El presente artículo tiene por objeto repensar la formación docente en tanto experiencia y práctica situada, territorial, subjetiva, singular y diferente. La metodología se basa en el análisis de las subjetividades formadas por conceptos, por reglas y prácticas que constituyen y modifican determinados sujetos sociales. Singularidades que producen relaciones con el cuerpo propio, cultural y múltiple, familiar, barrial, de colectivos y grupos, es el análisis de la formación docente y su relación con lo social. De experiencias de la diferencia de sujetos y colectivos que construyen saberes, políticas y éticas situadas en, con y desde los territorios. Entre los hallazgos encontramos que la formación docente deberá tener relación directa con las experiencias de los saberes situados en el territorio. Entre las conclusiones, primero, que la formación docente es una racionalidad social de prácticas para la formación y modificación de cuerpos, de situaciones y de contextos sociales, segundo, que ella se debate en relaciones territoriales, que es una experiencia situada sobre el suelo de la escuela y del barrio, una experiencia de la singularidad y de la diferencia, que se apropia de saberes, que se atribuye otros, que instaura pedagogías en la cotidianidad escolar, que produce resistencias y creaciones, que en el territorio la formación y el ejercicio docente crea políticas, economías, éticas y estéticas que constituyen una formación y ejercicio docente del lugar, de las situaciones y de los contextos situados en los territorios como ejercicios de diferencia social, política, ética y estética de expresión de sus propias libertades.

Palabras clave: Formación Docente. Territorios. Subjetividades. Singularidades. Diferencias.
A pedagogia da alternância e o Mestrado Profissional em Educação do Campo da Universidade Federal do Recôncavo da Bahia
Authors: Feitosa Débora Alves , Benísio Joel Duarte 
Published: August 2024

O presente artigo trata sobre a Pedagogia da Alternância e sua interface com a Educação do Campo. Recupera o histórico da Pedagogia da Alternância no Brasil e sua regulamentação legal. Faz um breve levantamento sobre a produção acadêmico-científica na pós-graduação acerca da Pedagogia da Alternância e apresenta a produção realizada no Mestrado Profissional em Educação do Campo da Universidade Federal do Recôncavo da Bahia sobre esse tema ao longo de sua existência. Caracteriza a alternância no âmbito do PPGEDUCAMPO, problematizando seus potenciais, limites e desafios.

Palavras-chave: Pedagogia da Alternância; Educação do Campo; Formação de Professores; Mestrado em Educação do Campo.
PERAN ISTRI NELAYAN DALAM RANGKA MENINGKATKAN ENDAPATANKELUARGA ( STUDI KASUS ISTRI NELAYAN DI GAMPONG PADANG BARU KECAMATAN SUSOH KABUPATEN ACEH BARAT DAYA )
Authors: Zuraidah Syarifah 
Published: August 2024

Penelitian ini dilaksanakan di Gampong Padang Baru, Kecamatan Susoh, Kabupaten Aceh Barat Daya. Pada bulan April 2018. Penelitian ini bertujuan utuk Menganalisis rata-rata kontribusi istri nelayan terhadap pendapatan total keluarga nelayan dan Untuk mengidentifikasi jenis-jenis pendapatan istri nelayan. Metode penelitian yang digunakan adalah metode survey. Pengumpulan data dilakukan dengan menggunakan kuesioner dari semua responden. Data yang diperoleh dari hasil penelitian ini dianalisis dengan menggunakan metode deskriptif kuantitatif .hasil penelitian menunjukan bahwa kontribusi pendapatan istri nelayan berpengaruh cukup besar yaitu sebesar 35,18 % terhadap pendapatan keluagra. Istri nelayan memperoleh pendapatan bekerja sebagai tukang nyuci/gosok, jual kue membuka kios, jahit menjahit, Peternak, penjaga anak dengan total rata-rata pendapatan sebesar Rp. 890.773.Kata kunci : Peranan, Suami Istri, Penghasilan, Rumah Tangga The research carried in Padang Baru Village, Sub- district Susoh, District Aceh Barat Daya. At April 2018. The purpose of this study for analyze the average contribution of the wives of the fishermen's to the total fishermen's family income and for identify kind of income by the wives of the fishermen's. The method of this research was survey method. Collection of data carried out by used questionnaires from all respondents. Data obtained from this study was analyzed using quantitative descriptive method. The results of this study showed that contribution of the wives income had a significant influence, namely 35.18% to fisherman's family income. The wives of fisherman's had income fom worked as a cleaning service, selled cake, open the kios, became a Tailor, a Farmers, became a baby sitter with total income was Rp. 890,773.Keywords: Role, Fisher Man Wife, Income, Household
The Relationship Between Maternal Stress Level and the Development of Children Aged 24-59 Months in Palembang City
Authors: Khilda Rahima , Rosyada Amrina 
Published: August 2024

The toddler period is a golden period where at the age of 0-5 years the growth and development of the toddler's brain increases rapidly. So every family needs to understand this golden age period so that children's growth and development can be achieved optimally. As individuals who are close to children, mothers have an important role in providing stimulation to children during their development. The study aims to examine the relationship between maternal stress levels and the development of children aged 24-59 months in Palembang City. The study is a quantitative analytic study with a cross-sectional approach. This study uses the design of a random sampling cluster with the number of samples of 128 respondents. There are 8 respondents (80%) of mothers with high levels of stress having children with inappropriate development. Stress levels are associated with child development (p-value=0.047; 95% CI=0.999-24.089) and the confounding variable associated with child development are maternal support system (p-value=<0.001; 95% CI=2.280-10.179). Mothers with high stress levels had a risk of having children with inappropriate development 2.182 times greater than mothers with low stress levels after controlling for the variable of support system (95% CI = 0.418 - 11.389).
The Anticancer Potency of Pandanus odoratissimus Extracts In Human Breast Cancer (MCF-7) Cell Line
Authors: Andriani Yosie , Yahya Rodhiyah , Gazali Mohamad , Amir Hermansyah , Subhan Beginer 
Published: August 2024

The development of novel chemical entities, novel pharmaceuticals, and novel drug leads frequently involves the use of natural sources. One of the most well-known plants, Pandanus odoratissimus (Pandanaceae), is native to Malaysia and has long been used in Ayurvedic medicine to treat a variety of illnesses. The purpose of this study is to determine P odoratissimus's antioxidant and anticancer properties against MCF-7 human breast cancer cell lines. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity was used to assess antioxidant activity, and among the other extracts, core exhibited the highest antioxidant value. An MTT assay was used to assess the effects of plant components on MCF-7 cell lines (3-(4, 5-dimethylthiazolyl)-2, 5-diphenyl-tetrazolium bromide). The concentration of samples was shown to considerably boost the antioxidant activities in P. odoratissimus extracts. Our findings demonstrated that, after receiving treatment for 72 hours, sample treated cancer cells experienced a decline in cell viability. The IC50 value of 88.00 mg/ml indicates that the extracts have a poor cytotoxic impact and have no promise as anticancer agents against MCF-7, which is why it’s killing efficiency in cancer cells is regarded as lower.