bluuebunny/crossref_metadata_2025_split huggingface dataset:
A large new leanchoiliid from the Burgess Shale and the influence of inapplicable states on stem arthropod phylogeny
Authors: Aria Cédric , Caron Jean‐Bernard , Gaines Robert 
Published: March 2015

AbstractCharacterized by atypical frontalmost appendages, leanchoiliids are early arthropods whose phylogenetic placement has been much debated. Morphological interpretations have differed, some of which concern critical characters such as the number of eyes and head appendages, but methodological approaches also have diverged. Here, we describe a new leanchoiliid, Yawunik kootenayi gen. et sp. nov., based on 42 specimens from the newly discovered Marble Canyon locality of the Burgess Shale (Kootenay National Park, British Columbia; middle Cambrian). This new morphotype demonstrates the presence of a four‐segmented head in leanchoiliids, along with two small antero‐median eyes in addition to lateral eyes. Yawunik is characterized by a 12‐segmented trunk and a carinate, lanceolate telson adorned with minute spines. The ‘great appendages’ of the animal bear teeth on their two distal rami, which would have enhanced their ability to grasp prey. Attitudes of specimens, resulting from burial at multiple aspects of bedding, suggest the ‘great appendages’ were flexible and capable of antero‐posterior rotation. We also discuss the nature of intersegmental tissues and filaments present within the ‘great appendages’. Our phylogenetic analyses extend the monophyly of leanchoiliids to include Haikoucaris and Yohoia in a new clade, the Cheiromorpha nom. nov. (within Heptopodomera nom. nov.). Other nodes are poorly resolved unless implied weights are used, and in this case, the topology is critically sensitive to the coding prerogative of inapplicable states (NAs). Both the traditional ‘Arachnomorpha’ hypothesis (NAs as additional states) and the more recently favoured ‘Artiopoda + Crustacea’ (NAs as uncertainties) were obtained using the same data set and outgroup. This result stresses, first, the historical importance of polarization over data content in scenarios of early arthropod evolution, and second, a pressing need to investigate the impacts of coding inapplicables, especially given the inflating effect of implied weights.
The impact of obesity on pediatric procedural sedation‐related outcomes: results from the Pediatric Sedation Research Consortium
Authors: Scherrer Patricia D. , Mallory Michael D. , Cravero Joseph P. , Lowrie Lia , Hertzog James H. , Berkenbosch John W. ,   the Pediatric Sedation Research Consortium
Published: March 2015

SummaryObjectivesTo evaluate the impact of obesity on adverse events and required interventions during pediatric procedural sedation.MethodsThe Pediatric Sedation Research Consortium database of prospectively collected procedural sedation encounters was queried to identify patients for whom body mass index (BMI) could be calculated. Obesity was defined as BMI ≥95th percentile for age and gender. Sedation‐related outcomes, adverse events, and therapeutic interventions were compared between obese and nonobese patients.ResultsFor analysis, 28 792 records were eligible. A total of 5 153 patients (17.9%) were obese; they were predominantly male and older and had a higher median American Society of Anesthesiologists Physical Status classification (P < 0.001). Total adverse events were more common in obese patients (odds ratio [OR] 1.49, 95% confidence interval [1.31, 1.70]). Respiratory events (airway obstruction OR 1.94 [1.54, 2.44], oxygen desaturation OR 1.99 [1.50, 2.63], secretions OR 1.48 [1.01, 2.15], laryngospasm OR 2.30 [1.30, 4.05]), inability to complete the associated procedure (OR 1.96 [1.16, 3.30]), and prolonged recovery (OR 2.66 [1.26, 5.59]) were increased in obese patients. Obese patients more frequently required airway intervention including repositioning, suctioning, jaw thrust, airway adjuncts, and bag‐valve‐mask ventilation. Multivariate regression analysis demonstrated obesity to be independently associated with minor and moderate but not major adverse events.ConclusionsObesity is an independent risk factor for adverse respiratory events during procedural sedation and is associated with an increased frequency of airway interventions, suggesting that additional vigilance and expertise are required when sedating these patients.
Anesthesia and the developing brain: a way forward for clinical research
Authors: Davidson Andrew J. , Becke Karin , de Graaff Jurgen , Giribaldi Gaia , Habre Walid , Hansen Tom , Hunt Rodney W. , Ing Caleb , Loepke Andreas , McCann Mary Ellen , Ormond Gillian D. , Pini Prato Alessio , Salvo Ida , Sun Lena , Vutskits Laszlo , Walker Suellen , Disma Nicola 
Published: March 2015

SummaryIt is now well established that many general anesthetics have a variety of effects on the developing brain in animal models. In contrast, human cohort studies show mixed evidence for any association between neurobehavioural outcome and anesthesia exposure in early childhood. In spite of large volumes of research, it remains very unclear if the animal studies have any clinical relevance; or indeed how, or if, clinical practice needs to be altered. Answering these questions is of great importance given the huge numbers of young children exposed to general anesthetics. A recent meeting in Genoa brought together researchers and clinicians to map a path forward for future clinical studies. This paper describes these discussions and conclusions. It was agreed that there is a need for large, detailed, prospective, observational studies, and for carefully designed trials. It may be impossible to design or conduct a single study to completely exclude the possibility that anesthetics can, under certain circumstances, produce long‐term neurobehavioural changes in humans; however , observational studies will improve our understanding of which children are at greatest risk, and may also suggest potential underlying etiologies, and clinical trials will provide the strongest evidence to test the effectiveness of different strategies or anesthetic regimens with respect to better neurobehavioral outcome.
Simple gene silencing using the trans‐acting siRNA pathway
Authors: Jacobs Thomas B. , Lawler Noah J. , LaFayette Peter R. , Vodkin Lila O. , Parrott Wayne A. 
Published: March 2015

SummaryIn plants, particular micro‐RNAs (miRNAs) induce the production of a class of small interfering RNAs (siRNA) called trans‐acting siRNA (ta‐siRNA) that lead to gene silencing. A single miRNA target is sufficient for the production of ta‐siRNAs, which target can be incorporated into a vector to induce the production of siRNAs, and ultimately gene silencing. The term miRNA‐induced gene silencing (MIGS) has been used to describe such vector systems in Arabidopsis. Several ta‐siRNA loci have been identified in soybean, but, prior to this work, few of the inducing miRNAs have been experimentally validated, much less used to silence genes. Nine ta‐siRNA loci and their respective miRNA targets were identified, and the abundance of the inducing miRNAs varies dramatically in different tissues. The miRNA targets were experimentally verified by silencing a transgenic GFP gene and two endogenous genes in hairy roots and transgenic plants. Small RNAs were produced in patterns consistent with the utilization of the ta‐siRNA pathway. A side‐by‐side experiment demonstrated that MIGS is as effective at inducing gene silencing as traditional hairpin vectors in soybean hairy roots. Soybean plants transformed with MIGS vectors produced siRNAs and silencing was observed in the T1 generation. These results complement previous reports in Arabidopsis by demonstrating that MIGS is an efficient way to produce siRNAs and induce gene silencing in other species, as shown with soybean. The miRNA targets identified here are simple to incorporate into silencing vectors and offer an effective and efficient alternative to other gene silencing strategies.
Identification of marker alleles linked to fire blight resistance QTLs in apple genotypes
Authors: Papp David , Békefi Zsuzsanna , Balotai Boglárka , Tóth Magdolna 
Published: March 2015

AbstractMolecular marker analysis can be an effective tool when searching for new fire blight resistance donors. It can speed up the breeding process as well, even though many of the available markers linked to fire blight resistance QTLs have not yet been tested by screening a large number of cultivars. The aim of this study was to search for alternate sources of the three major QTLs of fire blight resistance; FBF7, FB_MR5 and FB_E, as well as to test the efficiency of some markers linked to minor QTLs. Altogether, nine primer pairs were used on 77 genotypes including new Hungarian cultivars and old apple cultivars from the Carpathian basin. Several marker alleles of FB resistance QTLs have been detected in the screened genotypes, most importantly the alleles coupling with FB_MR5 in the old cultivars ‘Kéresi muskotály’, ‘Szabadkai szercsika’ and ‘Batul’. We propose these cultivars as the first available resistance donors of FB_MR5 instead of the crabapple Malus × robusta 5. The results also bring new information regarding the resistance alleles of new Hungarian cultivars and selections.
Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy
Authors: Wellbrock Claudia , Arozarena Imanol 
Published: March 2015

SummaryMalignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for this cell lineage is maintained in melanoma, where it is an important regulator of survival and balances melanoma cell proliferation with terminal differentiation (pigmentation). The MITF gene is amplified in ~20% of melanomas and MITF mutation can predispose to melanoma development. Furthermore, the regulation of MITF expression and function is strongly linked to the BRAF/MEK/ERK/MAP‐kinase (MAPK) pathway, which is deregulated in >90% of melanomas and central target of current therapies. MITF expression in melanoma is heterogeneous, and recent findings highlight the relevance of this heterogeneity for the response of melanoma to MAPK pathway targeting drugs, as well as for MITF's role in melanoma progression. This review aims to provide an updated overview on the regulation of MITF function and plasticity in melanoma with a focus on its link to MAPK signaling.
Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options
Authors: Geller Lauren , Antonov Nina K. , Lauren Christine T. , Morel Kimberly D. , Garzon Maria C. 
Published: March 2015

AbstractPityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English‐language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children. The proposed etiologies are discussed, including its association with infectious agents, medications, and immunizations and evidence for PL as a lymphoproliferative disorder. We found an average age of PL onset of 6.5 years, with a slight (61%) male predominance. We also found that PLEVA and PLC tend to occur with equal frequency and that, in many cases, there is clinical and histopathologic overlap between the two phenotypes. When systemic therapy is indicated, we propose that oral erythromycin and narrowband ultraviolet B phototherapy should be first‐line treatment options for children with PL since they have been shown to be effective and well tolerated. In most cases, PL follows a benign course with no greater risk of cutaneous T‐cell lymphoma, although given the rare case reports of transformation, long‐term follow‐up of these patients is recommended.
Are sexually permissive individuals more victimized and socially isolated?
Authors: VRANGALOVA ZHANA , BUKBERG RACHEL E. 
Published: March 2015

AbstractSexually permissive individuals are judged harshly by others, yet little research has examined whether these individuals themselves feel more victimized and socially isolated. Among 810 undergraduates (74% females; 38% non‐White; ages 18–23), linear, logistic, and negative binomial regressions indicated that, after controlling for demographics, higher numbers of lifetime casual sex partners predicted (a) more relational aggression experiences and sexual behavior‐based prejudice, but (b) less loneliness, greater likelihood of having a best friend, and higher numbers of close friends, acquaintances, and relatives. Controlling for extraversion rendered most isolation, but not victimization, links nonsignificant. There were few sex differences. Results suggest a complex relation between permissiveness, victimization, and isolation, indicating resiliency among permissive individuals in the face of adversity.
Advice Networks in Public Organizations: The Role of Structure, Internal Competition, and Individual Attributes
Authors: Siciliano Michael D. 
Published: March 2015

AbstractInterpersonal networks are increasingly important for organizational learning and performance. However, little is known about how these networks emerge. In this article, exponential random graph models are employed to explore the underlying processes of advice network formation in 15 organizations. The author examines the influence of (1) structural effects (reciprocity, transitivity, multiplexity), (2) actor attribute effects (job function, tenure, education, self‐efficacy), and (3) peer competition. Results suggest that employees rely more on reciprocity, closure, and similarity in job function than on peer expertise or status when seeking advice. In addition, employees who perceive greater levels of competition with peers are significantly less likely to both seek and provide advice. As public organizations look to private sector strategies that promote internal competition to improve efficiency and accountability, public managers need to be aware of the negative implications those strategies can have on interpersonal networks and organizational learning.
Demographic Factors and Price Distortions in Insurance
Authors: Cheung Ron , Cole Cassandra R. , Macpherson David A. , McCullough Kathleen A. , Nyce Charles 
Published: March 2015

AbstractFew papers have analyzed the potential linkages between price distortions and the specific demographic and political traits of customers. The existence of price distortions may have adverse and potentially unintended impacts on certain demographic groups, leading to significant public policy concerns. The current study uses census tract data and rating factors to examine age, income, and race demographics in an effort to determine if any subgroups of the population are adversely impacted by the price distortions of property insurance. The results suggest that Hispanics, lower income households, and specific age groups pay relatively more for insurance coverage than comparison groups.
Determinants and Value of Enterprise Risk Management: Empirical Evidence From the Literature
Authors: Gatzert Nadine , Martin Michael 
Published: March 2015

AbstractThe development of an enterprise risk management (ERM) program enables companies to manage corporate risks in a holistic manner as opposed to the silo‐based perspective in traditional risk management frameworks. One main question in this regard is what factors drive the implementation of an ERM system in companies and whether ERM programs can actually create value once implemented. This article addresses these questions by conducting a comparative assessment of empirical evidence from the literature regarding the determinants of ERM and its value once implemented. In doing so we are able to illustrate differences in model specifications and the underlying data. Our literature study shows that particularly the company size and the level of institutional ownership are significantly positively related to the implementation of ERM in most empirical studies and, furthermore, that ERM generally has a (significant) positive impact on corporate value and performance (to a different extent and depending on the focus of the studies). However, geographic and/or industrial restrictions regarding the underlying data sets partly limit the generalization of the empirical results.
Product Ratings as a Market Reaction to Deregulation: Evidence From the German Insurance Market
Authors: Meyr Stephanie , Tennyson Sharon 
Published: March 2015

AbstractThis study provides the first investigation of information markets as a reaction to deregulation of product forms in insurance markets. The article studies the case of Germany, where insurance product ratings entered the market after relaxation of product regulation in 1994. The ratings’ potential for enhancing the performance of a deregulated insurance market is analyzed by considering both market structure and governance characteristics of the rating market, since the theoretical literature predicts that both are important determinants of rating outcomes. Data from a unique panel data set containing disability insurance ratings from the three major rating agencies are also examined in light of theoretical predictions. Results suggest that market governance and competition characteristics are favorable for the production of unbiased and informative ratings. Ratings for disability insurance support this interpretation, since the characteristics of the ratings conform to theoretical predictions about ratings in well‐functioning rating markets.
Automobile Insurance Vehicle Repair Practices: Politics, Economics, and Consumer Interests
Authors: Cole Cassandra , Maroney Patrick , McCullough Kathleen , Powell Lawrence 
Published: March 2015

AbstractThere is a continuing debate related to insurers’ use of direct repair programs, in which they contract with particular body shops to perform insured auto repairs according to terms agreed to by the insurers and repair shop owners. A similar debate exists related to insurers specifying the use of aftermarket crash parts instead of original equipment manufacturer parts to replace damaged vehicle components, such as door panels, fenders, and hoods. This study examines these issues from a variety of perspectives providing initial evidence that if properly used, these cost containment tools can be beneficial to consumers and insurers.
Partially Latent Class Models for Case–Control Studies of Childhood Pneumonia Aetiology
Authors: Wu Zhenke , Deloria-Knoll Maria , Hammitt Laura L. , Zeger Scott L. ,   for the Pneumonia Etiology Research for Child Health Core Team
Published: March 2015

SummaryIn population studies on the aetiology of disease, one goal is the estimation of the fraction of cases that are attributable to each of several causes. For example, pneumonia is a clinical diagnosis of lung infection that may be caused by viral, bacterial, fungal or other pathogens. The study of pneumonia aetiology is challenging because directly sampling from the lung to identify the aetiologic pathogen is not standard clinical practice in most settings. Instead, measurements from multiple peripheral specimens are made. The paper introduces the statistical methodology designed for estimating the population aetiology distribution and the individual aetiology probabilities in the Pneumonia Etiology Research for Child Health study of 9500 children for seven sites around the world. We formulate the scientific problem in statistical terms as estimating the mixing weights and latent class indicators under a partially latent class model (PLCM) that combines heterogeneous measurements with different error rates obtained from a case–control study. We introduce the PLCM as an extension of the latent class model. We also introduce graphical displays of the population data and inferred latent class frequencies. The methods are tested with simulated data, and then applied to Pneumonia Etiology Research for Child Health data. The paper closes with a brief description of extensions of the PLCM to the regression setting and to the case where conditional independence between the measures is relaxed.
Modelling Short- and long -Term Characteristics of Follicle Stimulating Hormone as Predictors of Severe Hot Flashes in the Penn Ovarian Aging Study
Authors: Jiang Bei , Wang Naisyin , Sammel Mary D. , Elliott Michael R. 
Published: March 2015

SummaryThe Penn Ovarian Aging Study tracked a population-based sample of 436 women aged 35–47 years to determine associations between reproductive hormone levels and menopausal symptoms. We develop a joint modelling method that uses the individual level longitudinal measurements of follicle stimulating hormone (FSH) to predict the risk of severe hot flashes in a manner that distinguishes long-term trends of the mean trajectory, cumulative changes captured by the derivative of mean trajectory and short-term residual variability. Our method allows the potential effects of longitudinal trajectories on the health risks to vary and accumulate over time. We further utilize the proposed methods to narrow the critical time windows of increased health risks. We find that high residual variation of FSH is a strong predictor of hot flash risk, and that the high cumulative changes of the FSH mean trajectories in the 52.5–55-year age range also provides evidence of increased risk over that of short-term FSH residual variation by itself.
Assets and Affect in the Study of Social Capital in Rural Communities
Authors: Phillips Martin 
Published: March 2015

AbstractShucksmith (2012) has recently suggested that rural research might be refreshed by incorporating theoretical insights that have emerged through a renewal of class analysis. This article seeks to advance this proposed research agenda by exploring the concept of asset‐based class analysis and its association with the concept of social capital. The article explores connections between social capital, class analysis and understandings of community, noting how all have been associated with long running and unresolved debates. Attention is drawn to the problems of modernist legislative approaches to these debates and the value of adopting more interpretive perspectives. A distinction between ‘infrastructural’ and ‘culturalist’ interpretations of social capital is explored in relation to ‘asset‐based’ theorisations of class and culture. It is argued that an infrastructural conception of social capital might usefully be employed in association with a disaggregated conception of cultural capital that includes consideration of emotion and affect, as well as institutional, objectified and technical assets. These arguments are explored using studies of rural communities, largely within Britain.
Mycobacterium abscessus pulmonary infection complicated with vertebral osteomyelitis in a heart transplant recipient: case report and literature review
Authors: Silva J.T. , López‐Medrano F. , Fernández‐Ruiz M. , San‐Juan R. , Ruiz‐Cano M.J. , Delgado J.F. , Aguado J.M. 
Published: March 2015

AbstractInfections produced by Mycobacterium abscessus are emerging in immunosuppressed patients, such as solid organ transplant recipients. We report the first case, to our knowledge, of a vertebral osteomyelitis caused by M. abscessus in a heart transplant recipient, and review the risk factors, manifestations, and therapeutic approaches to this uncommon disease.