bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-plane imaging technology with constant imaging quality
Authors: Zhai Zhongsheng , Yu Xiatian , Zeng Zhen , Zhang Yi , Lv Qinghua , Liu Da , Tu Jun 
Published: July 2024

To realize three-dimensional microscopic imaging with high time resolution and high space resolution at the same time, a multi-plane imaging method with constant axial multi-plane imaging quality is proposed. The optical theory to ensure that different axial sections have consistent lateral resolution has been analyzed. In the system, it is proposed to superimpose a spatial light modulator with programmable ability and wavefront control function on the focal plane of the image square of the front group of the infinite tube length microscope objective and load a digital multiplexing lens with multi-focus and multi-diffraction angle to form a new combined imaging system. The system can clearly image any axial section or multiple target planes within a certain imaging range without compensating the imaging aberration of the axial section, so that each axial section has the same imaging quality. With the help of the USAF 1951 resolution chart, it is verified that different axial object planes have consistent lateral resolution up to 57.0 lp/mm. For samples with different thicknesses, multi-plane layer-by-layer imaging and multi-plane simultaneous imaging experiments were performed using single-focus lens, multi-focus Fresnel lens, and digital multiplexing lens phase grayscale images, respectively. Experimental results show that this scheme can achieve some degree of simultaneous multiplanar imaging with an axial spacing of up to 0.2 mm, which is potentially useful in research areas where samples should not be moved or where relative motion is not desirable.
Design and manufacture of a modified freeform Offner spectrometer with 0.6× magnification
Authors: Song Lingling , Chen Xinhua , Zhao Zhicheng , Wen Jiawang , Shen Weimin 
Published: July 2024

The Offner spectrometer is characterized by a lower F/#, excellent imaging quality, and small distortion, which are beneficial for symmetry and concentricity. However, its 1:1 magnification imposes a constraint on the design, manufacture, and alignment of foreoptics, especially with small F/# applications. The modified Offner spectrometer is hence proposed, and its design and manufacture are introduced in this paper. The initial structure parameters of the modified Offner spectrometer are solved with the wave aberration theory of a plane-symmetrical system. The primary and tertiary mirrors use the Zernike polynomial freeform surfaces to improve the imaging quality during optimization. The components of the designed modified Offner spectrometer are fabricated, and the spectral performance is measured after alignment. The measured spectral resolution is 3.91 nm, and the maximum smile and keystone are 1.37 and 1.8 µm, respectively, which are both less than 10% of the spatial and spectral dimension pixels.
SkipNet: an adaptive neural network equalization algorithm for future passive optical networking
Authors: Murphy Stephen L. , Townsend Paul D. , Antony Cleitus 
Published: July 2024

In this paper, we propose an original adaptive neural network equalizer (NNE) algorithm named SkipNet, which is suitable for rapid training on a packet-by-packet basis for burst-mode non-linear equalization in upstream PON transmission. SkipNet uses the simple LMS algorithm and avoids complex neural network training algorithms such as backpropagation and mini-batch training. We demonstrate SkipNet on captured continuous mode 100 Gbit/s PAM4 signals using an SOA preamplifier to achieve the challenging 29 dB PON optical loss budget. The adaptive SkipNet equalizer is shown to overcome combinations of severe SOA patterning effects and fiber dispersion impairments to achieve >29dB dynamic range back-to-back and >22.9dB dynamic range for up to 81.6 ps/nm accumulated dispersion. It can adapt in as little as 250 training symbols to each impairment scenario, which is equivalent to existing FFE/DFE solutions, while matching the non-linear performance of previously proposed static NNE solutions. To the best of our knowledge, SkipNet is the first ever adaptive NNE framework that can realistically be trained and adapted on a packet-by-packet basis and within strict PON packet preamble lengths.
Enhanced ultrafine multimode fiber imaging based on mode modulation through singular value decomposition
Authors: Zhan Ning , Yu Zhenming , Cheng Liming , Ma Jingyue , Di Jiayu , Lan Yueheng , Xu Kun 
Published: July 2024

The utilization of multimode fibers (MMFs) displays significant potential for advancing the miniaturization of optical endoscopes. However, the imaging quality is constrained by the physical conditions of MMF, which is particularly serious in small-core MMFs because of the limited mode quantity. To break this limitation and enhance the imaging ability of MMF to the maximum, we propose a mode modulation method based on the singular value decomposition (SVD) of MMF’s transmission matrix (TM). Before injection into the MMF, a light beam is modulated by the singular vectors obtained by SVD. Because the singular vectors couple the light field into eigenchannels during transmission and selectively excite the modes of different orders, the optimal distribution of the excited modes in MMF can be achieved, thereby improving the imaging quality of the MMF imaging system to the greatest extent. We conducted experiments on the MMF system with 40 μm and 105 μm cores to verify this method. Deep learning is utilized for image reconstruction. The experimental results demonstrate that the properties of the output speckle pattern were customized through the selective excitation of optical modes in the MMF. By applying singular vectors for mode modulation, the imaging quality can be effectively improved across four different types of scenes. Especially in the ultrafine 40 μm core MMF, the peak signal-to-noise ratio can be increased by up to 7.32 dB, and the structural similarity can be increased by up to 0.103, indicating a qualitative performance improvement of MMF imaging in minimally invasive medicine.
Evaluation of ex vivo drug combination optimization platform in recurrent high grade astrocytic glioma: An interventional, non-randomized, open-label trial protocol
Authors: Toh Tan Boon , Thng Dexter Kai Hao , Bolem Nagarjun , Vellayappan Balamurugan A. , Tan Bryce Wei Quan , Shen Yating , Soon Sou Yen , Ang Yvonne Li En , Dinesh Nivedh , Teo Kejia , Nga Vincent Diong Weng , Low Shiong Wen , Khong Pek Lan , Chow Edward Kai-Hua , Ho Dean , Yeo Tseng Tsai , Wong Andrea Li Ann 
Published: July 2024

Introduction
High grade astrocytic glioma (HGG) is a lethal solid malignancy with high recurrence rates and limited survival. While several cytotoxic agents have demonstrated efficacy against HGG, drug sensitivity testing platforms to aid in therapy selection are lacking. Patient-derived organoids (PDOs) have been shown to faithfully preserve the biological characteristics of several cancer types including HGG, and coupled with the experimental-analytical hybrid platform Quadratic Phenotypic Optimization Platform (QPOP) which evaluates therapeutic sensitivity at a patient-specific level, may aid as a tool for personalized medical decisions to improve treatment outcomes for HGG patients.

Methods
This is an interventional, non-randomized, open-label study, which aims to enroll 10 patients who will receive QPOP-guided chemotherapy at the time of first HGG recurrence following progression on standard first-line therapy. At the initial presentation of HGG, tumor will be harvested for primary PDO generation during the first biopsy/surgery. At the point of tumor recurrence, patients will be enrolled onto the main study to receive systemic therapy as second-line treatment. Subjects who undergo surgery at the time of recurrence will have a second harvest of tissue for PDO generation. Established PDOs will be subject to QPOP analyses to determine their therapeutic sensitivities to specific panels of drugs. A QPOP-guided treatment selection algorithm will then be used to select the most appropriate drug combination. The primary endpoint of the study is six-month progression-free survival. The secondary endpoints include twelve-month overall survival, RANO criteria and toxicities. In our radiological biomarker sub-study, we plan to evaluate novel radiopharmaceutical-based neuroimaging in determining blood-brain barrier permeability and to assess in vivo drug effects on tumor vasculature over time.

Trial registration
This trial was registered on 8th September 2022 with ClinicalTrials.gov Identifier: NCT05532397.
Evaluation of dental manifestations in X-linked hypophosphatemia using orthopantomography
Authors: Okawa Rena , Takagi Misato , Nakamoto Takashi , Kakimoto Naoya , Nakano Kazuhiko 
Published: July 2024

Background
X-linked hypophosphatemia (XLH) is the most common inherited form of rickets. The presence of sequence variations in the phosphate regulating endopeptidase homolog X-linked (PHEX) gene is associated with increased production of fibroblast growth factor 23 (FGF23). This results in renal phosphate wasting and impaired skeletal mineralization. Spontaneous dental abscesses, caused by endodontic infections resulting from hypomineralization of dentin, are a known dental complication of XLH. There is no objective method to evaluate the severity of dentin dysplasia. The purpose of this study was to develop a quantitative method to evaluate dentin dysplasia using orthopantomography that would allow the values in patients with XLH to be compared with the values in healthy participants of the same age.

Methods
The severity of dentin dysplasia was analyzed by measuring the pulp cavity area of the tooth using orthopantomographic images. The teeth analyzed were mandibular second primary molars and mandibular first permanent molars with complete root formation. Teeth with dental caries, restorations, or root resorption were excluded.

Results
This retrospective observational study included a total of 200 images of healthy participants (aged 2–15 years) divided into five age groups and 42 images of 17 patients with XLH. There was a significant tendency for the pulp cavity area to decrease with increasing age in primary and permanent teeth. The pulp chambers of patients with XLH were larger than those of healthy participants in primary and permanent teeth.

Conclusion
We have established a method of using orthopantomography for quantitative assessment of dentin dysplasia in XLH from the primary dentition to the permanent dentition. Evaluating the severity of dentin hypomineralization by this method is useful in the diagnosis of the dental manifestations of XLH. Early diagnosis of XLH enables oral management and leads to prevention of dental abscesses.
Termomechanical Treatment of Recycled Polyethylene Terephthalate (PET) Refuse: A Way to Avoid its Waste
Authors: Scari Alexandre , Cipriano Júnior Giovane 
Published: July 2024

During the recycling process of polyethylene terephthalate (PET), particles with low granulometry (refuse) may stick to the screw of the extruder and be discarded. In order to avoid its disposal, this research carries out a hot pressing of this refuse to allow its use. First, the ideal duration of hot pressing for this case was determined. Next, the resulting material was evaluated by drilling and manual sawing processes, and its mechanical properties were obtained by compression tests. The medium elastic modulus obtained by experimental tests was 1.13 GPa and, its medium strength, 68.5 MPa. Yet, the resulting material presented satisfactory performance by drilling and manual sawing processes.
Using Diet to Treat Inflammatory Bowel Disease: A Systematic Review
Authors: Gleave Alexandra , Shah Aryan , Tahir Umair , Blom Jedid-Jah , Dong Ethan , Patel Ayush , Marshall John K. , Narula Neeraj 
Published: July 2024

INTRODUCTION:
To review the efficacy of various dietary interventions for induction of clinical remission in inflammatory bowel disease (IBD) and provide healthcare providers with a practical reference for recommending suitable diets for managing patients with IBD.

METHODS:
PubMed, Medline(R), and Cochrane were searched from inception up to February 17, 2023, to identify all studies reporting information on using diet to treat IBD. Studies investigating the role of dietary interventions in adult patients with a confirmed diagnosis of active IBD for improvement or remission of IBD symptoms were rigorously considered. Sample meal plans, with a list of included and excluded foods, were also generated to provide clinicians with practical tools for advising patients on dietary intake.

RESULTS:
Eleven included studies provided data on 10 distinct diets: autoimmune protocol diet, high-fiber diet, 4-strategies-to-SUlfide-Reduction diet, highly restricted diet, McMaster elimination diet for Crohn's disease, specific carbohydrate diet, Mediterranean diet, Crohn's disease exclusion diet, individualized elimination diet, and the food-specific IgG4-guided exclusion diet. A total of 9 studies provided data on clinical remission. Many of these diets share common elements, such as an initial elimination phase with subsequent reintroduction of dietary components, inclusion of whole foods, and exclusion of highly or ultraprocessed foods.

DISCUSSION:
Currently, there is limited evidence to support the use of specific diets to treat adult patients with mildly to moderately active IBD. Larger, randomized studies with standardized methodologies and outcome measures, rigorous adherence assessment, and an emphasis on endoscopic assessment outcome measures are required to validate most diets that have been studied for IBD. The included sample diet plans and dietary recommendations may prove helpful in the interim as part of a holistic strategy to manage patients with IBD.
A ambientalização curricular em um curso de licenciatura em ciências biológicas: experiências docentes sob a perspectiva ecofenomenológica
Authors: Aloisio Rafael Margatto , Iared Valéria Ghisloti 
Published: July 2024

O objetivo deste trabalho foi investigar a ambientalização curricular sob o olhar das experiências vivenciadas por professores de um curso de Licenciatura em Ciências Biológicas. A investigação, pautada em referenciais ecofenomenológicos, foi desenvolvida na Universidade Federal do Paraná com o curso de Licenciatura em Ciências Biológicas. Após a análise do Projeto Pedagógico Curricular e das ementas das disciplinas do curso, percebeu-se que 21 disciplinas eram condizentes com a ambientalização curricular. Seis docentes responsáveis pelas disciplinas foram convidados a participar de uma entrevista por meio de um walking ethnography, que resultaram em seis narrativas. Por meio da análise das seis narrativas, emergiram três categorias intituladas de: i) Postura cotidiana; ii) Memórias; e iii) Relação pessoal e profissional. As discussões demonstram a importância de abordar as temáticas ambientais na Educação Superior de forma que propiciem reflexões e vivências para além do antropocentrismo.
Um Bildungsroman fora do cânone? Rahel Varnhagen, A Vida De Uma Judia Alemã Na Época Do Romantismo, de Hannah Arendt
Authors: Eccel Daiane 
Published: July 2024

Resumo: A principal biógrafa de Hannah Arendt, Elisabeth Young-Bruehl indaga se a obra de Arendt a respeito de Rahel Varnhagen não seria um tipo sui generis de Bildungsroman. Nossa proposta é investigar o livro de Arendt sob este questionamento: há elementos formativos neste trabalho de Arendt? Para enfrentar tal tema, nos propomos a discutir a relação entre o contexto histórico de Rahel, associado às suas experiências individuais segundo a leitura da própria Arendt. Nossa hipótese é que esta hibridez presente no texto de Arendt, ou seja, as instituições culturais em conflito com o sofrimento de Rahel, constituem sua própria formação. Neste sentido, a obra poderia ser lida como um Bildungsroman, ainda que a intenção de Arendt não fosse essa ao escrevê-la.
Palavras-chave: Hannah Arendt; Romance de Formação; Educação; Estética
A Bildungsroman outside the canon? Rahel Varnhagen, The Life Of Jewess Woman, by Hannah Arendt
Abstract: The main biographer of Hannah Arendt, Elisabeth Young-Bruehl, wonders if the work from Arendt about Rahel Varnhagen would not be a sui generis type of Bildungsroman. This article proposes to investigate the book of Arendt under this question: are there, in fact, formative elements in the work Rahel Varnhagen: the life of a Jewish woman? To this end, we propose to discuss the relationship between historical context of Rahel associated with her individual experiences according to Arendt. Our hypothesis is that this hybridity present in this text from Arendt, that is, the cultural institutions in conflict with the suffering of Rahel, constitute her own formation. In this sense, the work could be read as a Bildungsroman, even though this was not the first intention for Hannah Arendt.
Keywords: Hannah Arendt; Bildungsroman; Education; Aesthetics
Ein Bildungsroman außerhalb des kanons? Rahel Varnhagen, Lebensgeschichte Einer Deutschen Jüdin Aus Der Romantik, von Hannah Arendt
Zusamennfassung: Die Hauptbiografin von Hannah Arendt, Elisabeth Young-Bruehl, fragt sich, ob das Buch von Arendt über Rahel Varnhagen nicht eine Art Bildungsroman sui generis sei. In diesem Artikel soll das Buch von Arendt über Rahel auf diese Frage hin untersucht werden: Gibt es tatsächlich prägende Elemente in Rahel Varnhagen, Lebensgeschichte einer Deutschen Jüdin aus der Romantik? Zu diesem Zweck schlagen wir vor, die Beziehung zwischen dem historischen Kontext von Rahel und ihren individuellen Erfahrungen nach Arendt zu diskutieren. Unsere Hypothese ist, dass diese Hybridität in diesem Text von Arendt, das heißt, die kulturellen Institutionen im Konflikt mit dem Leiden von Rahel ihre eigene Bildung. In diesem Sinne könnte das Werk als Bildungsroman gelesen werden, auch wenn dies nicht die erste Absicht von Hannah Arendt war.
Mots-clés: Hannah Arendt; Bildungsroman; Erziehung; Ästhetik

Data de registro: 16/01/2023
Data de aceite: 18/10/2023
Rekonseptualisasi <i>Model Citizen Lawsuit</i> dan Pengoptimalan <i>Society 5.0</i> Sebagai Upaya Reformasi Penegakan Hukum Acara Perdata di Indonesia
Authors: Ridlo Ahmad Rayhan Thoha , Alfandy Muhammad Daffa , Rahmadianingrum Azaria 
Published: July 2024

Abstract: The presence of the citizen lawsuit model in civil procedural law enforcement is one example that the law is dynamic following the development of human direction and mindset. Citizen lawsuit is defined as a model lawsuit that was born and known in a country with a common law legal system where citizens on behalf of the public interest are given space to file a lawsuit against unlawful acts committed by state administrators. However, countries that adopt the civil law legal system also implement it, such as the Netherlands which is known as actio popularis and Indonesia. The problem is, the implementation of this lawsuit model has not been regulated at all by national law, causing the practice of citizen lawsuits that have not been uniform, but have a disparity pattern (not uniform). In this paper, the author reconceptualizes the citizen lawsuit model as an effort to create integrated and systematic civil procedural law enforcement. The reconceptualization of the citizen lawsuit model consists of 4 (four) stages, namely the petition system stage, the notification stage, the administrative stage, and the judicial stage.

Abstrak: Kehadiran model citizen lawsuit dalam penegakan hukum acara perdata merupakan salah satu contoh bahwasannya hukum bersifat dinamis mengikuti perkembangan arah serta pola pikir manusia. Citizen lawsuit didefinisikan sebagai suatu model gugatan yang lahir dan dikenal dalam negara dengan sistem hukum common law dimana warga negara atas nama kepentingan umum diberi ruang untuk mengajukan gugatan terhadap perbuatan melawan hukum yang dilakukan oleh penyelenggara negara. Namun, negara-negara yang menganut sistem hukum civil law pun turut melaksanakannya, seperti Belanda yang dikenal dengan istilah actio popularis dan Indonesia. Permasalahannya, pelaksanaan model gugatan ini belum diatur sama sekali oleh hukum nasional sehingga menimbulkan praktik citizen lawsuit yang belum bercorak uniformitas (seragam), melainkan bercorak disparitas (tidak seragam). Dalam tulisan ini, Penulis merekonseptualisasikan model citizen lawsuit sebagai upaya menciptakan penegakan hukum acara perdata yang terintegrasi dan sistematis. Rekonseptualisasi model citizen lawsuit terdiri atas 4 (empat) tahapan, yaitu tahap sistem petisi, tahap notifikasi, tahap administrasi, dan tahap yudisial.
Konstruksi Leniency Program Sebagai Penumpasan Politik Teritorial Pertambangan dalam Perwujudan Ecological Citizenship
Authors: Yustika Anindya , Abimanyu Mevlana El Rumi , Yhauma MuttamIimul 
Published: July 2024

Abstract: Indonesia's abundant natural resources, particularly minerals and coal, prompted this study. Article 33(3) of the 1945 Constitution explicitly states that natural resources should benefit the people. However, illegal mining persists, profiting only a select few. Therefore, implementing the Leniency Program in Indonesia is crucial to fostering ecological citizenship. This legal research employs a normative juridical approach, incorporating conceptual and legislative perspectives. The findings indicate ongoing law enforcement issues in the mining sector, involving mining mafias. Consequently, the Leniency Program could serve as a novel strategy to eradicate mining mafias. Abstrak: Penelitian ini dilatarbelakangi oleh kekayaan sumber daya alam Indonesia, khususnya mineral dan batu bara. Sebagaimana yang diamanatkan dalam Pasal 33 Ayat 3 UUD 1945, sumber daya alam harus dimanfaatkan untuk sebesar-besarnya kemakmuran rakyat. Namun pada kenyataannya, praktik pertambangan ilegal masih marak terjadi dan hanya menguntungkan segelintir pihak. Oleh karena itu, penerapan Program Leniency menjadi penting untuk dikaji dalam rangka penegakan keadilan ekologi di Indonesia. Penelitian ini menggunakan metode penelitian hukum yuridis normatif dengan pendekatan konseptual dan perundang-undangan. Hasil penelitian menunjukkan masih adanya permasalahan penegakan hukum di sektor pertambangan, yang melibatkan mafia pertambangan. Dengan demikian, Program Leniency dapat menjadi strategi baru untuk memberantas mafia tambang.
Salt, clay, and society: Towards a reconstruction of salt-making
chaînes opératoires
in the Bronze and Early Iron Age in the Kraków–Wieliczka salt-bearing region
Authors: Dzięgielewski Karol , Mazur Michał 
Published: July 2024

Abstract
The progress of field research and studies of archaeological sites from southern Poland (Małopolska) and experimental activities related to salt-making in the Bronze Age and Early Iron Age in the last two decades have created conditions for attempting to recreate the chaîne opératoire of this branch of prehistoric production. The use of ceramic containers for evaporating brine and drying and portioning salt means that we are dealing with two operational sequences (production of ceramics and salt) intertwined at some stage – from obtaining raw materials (clay and brine) to the distribution of transportable product and discarding of disposable containers. We conducted multi-aspect studies on the characteristics of materials related to each stage, including their spatial location, based on all available material from western Małopolska, in particular several large-scale benchmark sites (Podłęże 17, Brzezie 17 and Kraków-Bieżanów 11). This allowed us to identify certain differences in production sites. A comprehensive review of the source database also allowed us to establish a rather limited scope of both the degree of craft specialisation of the brewers and the scale of the centre’s influence. Nevertheless, in some periods, as in the beginning of the Urnfield period, this centre gained supra-regional importance, as evidenced by, among others, certificates of weight standardization of finished products.