bluuebunny/crossref_metadata_2025_split huggingface dataset:
Birth defects in medically assisted reproduction pregnancies in the city of Barcelona
Authors: Gutarra‐Vilchez Rosa , Santamariña‐Rubio Elena , Salvador Joaquin , Borrell Antoni 
Published: November 2013

ABSTRACTObjectiveTo assess the association between the use of medically assisted reproduction (MAR) and birth defects (BD) in newborns and terminations of pregnancy in pregnant women registered in Barcelona in the period 1992 to 2007.MethodsWe studied 1905 cases and 2722 controls in a retrospective population‐based case–control study. Cases comprised any newborn presenting at least one major BD, as well as any pregnancy terminated because of BD. Controls were newborns without BD. Exposure was MAR. Adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated by means of logistic regression to assess the association.ResultsThe MAR was demonstrated to be associated with BD, after adjusting for probable confounders (aOR = 1.8; 95% CI = 1.4 to 2.5). Regarding MAR modalities, this association was statistically significant only for assisted reproduction techniques (ART) (aOR = 2.7; 95% CI = 1.8 to 4.1). In the stratified analysis by structural BD categories, frequencies for all categories were increased after ART with the exception of head‐face‐neck‐eye defects, none after artificial insemination, and digestive‐abdominal wall defects in ovulation induction.ConclusionsThis study demonstrated a strong association between ART and BD, with an almost threefold increased risk for overall BD after ART, as compared with natural conception. Increased associations were also observed for almost all structural BD categories. © 2013 John Wiley & Sons, Ltd.
Synthesis of a phosphinated acetoxybenzoic acid and its application in enhancing Tg and flame retardancy of poly(ethylene terephthalate)
Authors: Lin Ching Hsuan , Huang Chu Ming , Wang Meng Wei , Dai Shenghong A. , Chang Hou Chien , Juang Tzong Yuan 
Published: November 2013

ABSTRACTA new phosphinated acetoxybenzoic acid, 1‐(4‐acetoxyphenyl)‐1‐(4‐carboxylphenyl)‐1‐(6‐oxido‐6H‐dibenz<c,e><1,2> oxaphosphorin‐6‐yl)ethane (3), was prepared by a three‐step procedure. Phosphinated copolyesters based on the acidolysis and polycondensation of (3) with poly(ethylene terephthalate) (PET) were prepared. The crystallinity of copolyesters decreased gradually with the content of (3), as shown in wide‐angle X‐ray diffractograms and differential scanning calorimetry thermograms. Dynamic mechanical analysis and thermal mechanical analysis show Tg increased with the content of (3). UL‐94 flame retardant test shows that the flame resistance of PET was enhanced with the content of (3), and a copolyester with UL‐94 V‐0 grade can be achieved with a phosphorus content as low as 1.43 wt %. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 424–434
The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia
Authors: Brachtl Gabriele , Piñón Hofbauer Josefina , Greil Richard , Hartmann Tanja Nicole 
Published: November 2013

AbstractThe interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in shaping these interactions. Both are reported to influence CLL cell trafficking between blood and lymphoid organs as well as their survival and proliferation within the lymphoid organs, thereby impacting the pathophysiology of the disease. The expression of CD38 and CD49d is associated in the majority of cases, and they exist as part of macromolecular complexes. Here, we review the current evidence for the individual and associated contributions of these molecules to CLL pathophysiology.
Ein- und Ausschliessungspraktiken als Konstituierung von Grenzen
Authors: Heite Catrin , Pomey Marion , Spellenberg Charlotte 
Published: November 2013

ZusammenfassungGrenzen haben symbolische und soziale Bedeutung, reproduzieren durch moralisierende Zuschreibungen soziale Ungleichheiten und generieren Ein- und Ausschlüsse bestimmter Personen(gruppen). Grenzen bzw. eine grenzanalytische Perspektive sind für die Sozialpädagogik deshalb relevant, weil sie Aufschluss geben über normative Ordnungsvorstellungen sowie die eigene sozialpädagogische Beteiligung hieran. Normative Ordnungen ziehen Grenzen zwischen krisenhaftem Sein und idealem Sollen und bringen soziale Wirklichkeiten hervor. Durch so konstituierte Grenzverhältnisse von Wirklichkeit und Möglichkeit lassen sich auch empirisch Grenzziehungen rekonstruieren, die Ein- und Ausschlüsse hervorbringen. Dies wird im Artikel exemplarisch für die sozialpädagogische Handlungspraxis herausgearbeitet und normative Ordnungen von „guter“ und „schlechter“ Elternschaft rekonstruiert. Eine grenzanalytische Perspektive macht damit (Un)Möglichkeiten des (Anders-)Seins als kontingente und normativ plausibilisierte Ausschließungen erkennbar und legt sozialpädagogische Wirklichkeitskonstruktionen samt ihrer Konsequenzen in ihrer Bearbeitbarkeit offen.
Implementing AORN Recommended Practices for Prevention of Retained Surgical Items
Authors: Goldberg Judith L. , Feldman David L. 
Published: November 2013

AbstractRetention of a surgical item is a preventable event that can result in patient injury. AORN's “Recommended practices for prevention of retained surgical items” emphasizes the importance of using a multidisciplinary approach for prevention. Procedures should include counts of soft goods, needles, miscellaneous items, and instruments, and efforts should be made to prevent retention of fragments of broken devices. If a count discrepancy occurs, the perioperative team should follow procedures to locate the missing item. Perioperative leaders may consider the use of adjunct technologies such as bar‐code scanning, radio‐frequency detection, and radio‐frequency identification. Ambulatory and hospital patient scenarios are included to exemplify appropriate strategies for preventing retained surgical items.
Implementing AORN Recommended Practices for Sterilization
Authors: Graybill‐D'Ercole Patricia 
Published: November 2013

AbstractAny hospital or facility in which surgery and other invasive procedures are performed should have accommodations for cleaning, decontaminating, disinfecting, and sterilizing instruments, equipment, and other essential supplies that are used for patient procedures. Sterilization is essential to reducing or preventing the risk of surgical site infections. This is a collaborative process and should include all health care providers who handle these instruments, including perioperative nurses. The revised AORN “Recommended practices for sterilization,” which became effective June 15, 2012, includes updates on sterilizing single‐use items, inspecting critical items before sterilization, using low‐temperature hydrogen peroxide vapor sterilization methods, and immediate use steam sterilization. This RP document is the first AORN document to be evidence rated and accepted for inclusion in the Agency for Healthcare Research and Quality National Guideline Clearinghouse.
A trajectory equation for walking droplets: hydrodynamic pilot-wave theory
Authors: Oza Anand U. , Rosales Rodolfo R. , Bush John W. M. 
Published: November 2013

AbstractWe present the results of a theoretical investigation of droplets bouncing on a vertically vibrating fluid bath. An integro-differential equation describing the horizontal motion of the drop is developed by approximating the drop as a continuous moving source of standing waves. Our model indicates that, as the forcing acceleration is increased, the bouncing state destabilizes into steady horizontal motion along a straight line, a walking state, via a supercritical pitchfork bifurcation. Predictions for the dependence of the walking threshold and drop speed on the system parameters compare favourably with experimental data. By considering the stability of the walking state, we show that the drop is stable to perturbations in the direction of motion and neutrally stable to lateral perturbations. This result lends insight into the possibility of chaotic dynamics emerging when droplets walk in complex geometries.
Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies
Authors: Je Youjin , Giovannucci Edward 
Published: November 2013

Coffee consumption has been shown to be associated with various health outcomes, but no comprehensive review and meta-analysis of the association between coffee consumption and total mortality has been conducted. To quantitatively assess this association, we conducted a meta-analysis of prospective cohort studies. Eligible studies were identified by searching the PubMed and EMBASE databases for all articles published through June 2013 and reviewing the reference lists of the retrieved articles. Pooled relative risks (RR) with 95 % CI were calculated using a random-effects model. We identified twenty studies of coffee consumption and total mortality, including 129 538 cases of deaths among the 973 904 participants. The RR of total mortality for the high v. low category of coffee consumption was 0·86 (95 % CI 0·80, 0·92). The pooled RR for studies using ≥ 2–4 cups/d as a cut-off for the high category was similar to that for studies using ≥ 5–9 cups/d as the cut-off. By geographical region, the inverse association tended to be stronger for the eight studies conducted in Europe (RR 0·78, 95 % CI 0·70, 0·88) and three studies carried out in Japan (RR 0·82, 95 % CI 0·73, 0·92) than for the nine studies conducted in the USA (RR 0·92, 95 % CI 0·84, 1·00). The inverse association was similar for men (RR 0·81, 95 % CI 0·73, 0·90) and women (RR 0·84, 95 % CI 0·79, 0·89). A weak, but significant, inverse association was found with moderate coffee consumption (1–2 cups/d; RR 0·92, 95 % CI 0·87, 0·98). High decaffeinated coffee consumption was also found to be associated with a lower risk of death, but the data are limited. Our findings indicate that coffee consumption is associated with a reduced risk of total mortality.
Sandstone composition of the Upper Jurassic Emuerhe Formation from the Mohe Basin, China
Authors: ZHANG MING MING , LIU ZHAO JUN , FANG SHI , SUN QIU SHI 
Published: November 2013

AbstractThe sandstone composition analysis carried out on the samples from three different sections (western section, middle section and eastern section) of the Upper Jurassic Emuerhe Formation in the Mohe Basin, northeastern China, reveals that the Okhotsk orogenic belt and the Ergun massif basement are the source areas for the Emuerhe Formation. The source area of the western section and the A segment of the middle section is the Okhotsk orogenic belt. The tectonic attributes of the Okhotsk orogenic belt are those of a dissected arc. The transportation distance of clastic rocks from these sections gradually lengthened, and the uplift rate of the Okhotsk orogenic belt gradually increased. The source area of the eastern section and the B segment of the middle section is the Ergun massif basement. Compared with the Okhotsk orogenic belt, the tectonic attributes and uplift rate of the Ergun massif basement are different from the former. The attributes of the Ergun massif basement are those of basement uplift. The transportation distance of clastic rocks from the eastern section and the B segment of the middle section gradually shortened, and the uplift rate of the Ergun massif basement gradually decreased. These conclusions are consistent with the characteristics of a foreland basin. Thus, we can draw the conclusion that the Mohe Basin belongs to the foreland basin.
From explorer to expert: Sir William Martin Conway's ‘delightful sense of something accomplished’
Authors: Jones Mary Katherine 
Published: November 2013

ABSTRACTIn 1896, Sir William Martin Conway led an expedition to the Arctic archipelago of Svalbard, then a terra nullius. It was the first expedition to cross the interior of the main island, Spitsbergen. Was Conway an ‘expert’ explorer or an enthusiastic amateur, or something in-between? This article examines Conway's comparisons of Arctic versus Alpine in his expedition narrative, The first crossing of Spitsbergen, and his portrayal of expedition members’ expertise and shortcomings. Distinctions between Arctic explorers, travellers and tourists at that time are assessed, as is Conway's occasional tendency to highlight the polar aspects of his homeland while perceiving the island of Spitsbergen in a notably English light. Conway's expert status developed with the subsequent publication of journal articles and No man's land, the first history of Svalbard. In the latter, his simplicity of style and form, and the pronounced British bias of the main narrative, contrast with the scholarly breadth and focus of the final reference sections, which acted as a catalyst for subsequent international bibliographical and cartographical compilations relating to the region.
EXAMINER Executive Function Battery and Neurologic Morbidity in Pediatric Sickle Cell Disease
Authors: Schatz Jeffrey , Stancil Melita , Katz Tal , Sanchez Carmen E. 
Published: November 2013

AbstractSickle cell disease (SCD) is blood disorder with a high risk for cerebral vascular morbidities that impact neurocognitive functioning. Specific cognitive abilities are known to be more sensitive to neurologic effects of SCD than IQ scores, yet there is little consensus about which measures to use to assess neurocognitive functioning. We evaluated the ability of the Executive Abilities: Methods and Instruments for Neurobehavioral Evaluation and Research (EXAMINER) Battery to detect neurologic effects in SCD. Thirty-two youth with SCD and sixty demographically-matched comparison youth completed the EXAMINER Battery and selected tests from the Woodcock-Johnson Tests of Cognitive Ability, 3rdedition (WJ-III). Neurologic severity was examinedviaclinical history for morbidities and midsagittal corpus callosum (CC) area. Results indicated cognitive performance decreased with increasing neurologic morbidity across all cognitive measures; two of four EXAMINER factors were related to CC area. The association with clinical history and midsagittal CC area appeared at least as large for the Examiner Battery scores as for the WJ-III measures. The Examiner Battery showed sensitivity to neurologic history and white matter effects in SCD; this new measure compares favorably to established measures of disease-related neurocognitive effects, but would benefit from further development. (JINS, 2014,1, 1–12)
Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish
Authors: Yeh Da-Wei , Liu Yi-Ling , Lo Yin-Chiu , Yuh Chiou-Hwa , Yu Guann-Yi , Lo Jeng-Fan , Luo Yunping , Xiang Rong , Chuang Tsung-Hsien 
Published: November 2013

SignificanceZebrafish Toll-like receptor (TLR) 9 (zebTLR9) and TLR21 (zebTLR21) have distinct CpG-oligodeoxynucleotide (CpG-ODN) sequence recognition profiles. The recognition profile of zebTLR9 is more like that of the TLR9s from mouse and rabbit, whereas the recognition profile of zebTLR21 is more similar to that of human TLR9 and TLR9s from domestic animals. These two zebTLRs are requlated by UNC93B1 and cooperatively mediate the immunologic and antimicrobial responses induced by CpG-ODN in zebrafish. Our findings address the molecular basis of CpG-ODN activities in zebrafish and provide information for the rational design of CpG-ODN for use as an antimicrobial agent in fishes.
Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia
Authors: Anderson Erik R. , Taylor Matthew , Xue Xiang , Ramakrishnan Sadeesh K. , Martin Angelical , Xie Liwei , Bredell Bryce X. , Gardenghi Sara , Rivella Stefano , Shah Yatrik M. 
Published: November 2013

Significance
Several distinct congenital disorders can lead to tissue-iron overload with anemia. Tissue-iron accumulation is the major cause of mortality in these patients. Intestinal hypoxia-inducible factor-2α (HIF2α) and its downstream target gene divalent metal transporter-1 (DMT1) are essential for iron absorption during times of increased iron demand. However, the role of the intestinal HIF2α/DMT1 signaling axis in iron overload disorders has not been assessed. We demonstrate that HIF2α and DMT1 in the small intestine are highly activated early in mouse models of anemic iron overload and that disruption of their expression can prevent and improve tissue-iron accumulation in these disorders. These results demonstrate that HIF2α and DMT1 are ideal therapeutic targets in iron-overload disorders.
First Report of Orange Rust of Sugarcane Caused by Puccinia kuehnii in Ecuador
Authors: Garcés F. F. , Fiallos F. F. , Silva E. , Martinez F. , Aime M. C. , Comstock J. C. , Glynn N. C. , Castlebury L. A. 
Published: November 2013

Orange rust, Puccinia kuehnii (W. Krüger) E.J. Butler, is an important disease of sugarcane (complex hybrid of Saccharum L. species) that causes up to 53% yield loss (3), and can eliminate sugarcane clones in breeding programs. Initially confined to the Asia-Oceania region, P. kuehnii was reported in Florida in June 2007 (2) followed by confirmation in Central and South America. Orange rust pustules were observed on August 5, 2011, in commercial sugarcane fields located in the Ecuadorian Pacific coast of South America. Pustules were observed on cultivar SP79-2233 and sugarcane clones of the CINCAE breeding program (EC06-351, EC06-340, and EC01-744). Low levels of disease incidence and severity were observed in the sugarcane germplasm. Observation under a light microscope showed typical irregularly echinulate urediniospores that were pale in color with thickened apices and paraphyses inconspicuous to absent, such as those reported to be P. kuehnii (4). DNA of urediniospores were extracted and amplified using Pk1F and PK1R qPCR primers (5). Additionally, the 28s large ribosomal subunit DNA was sequenced (1), resulting in a qPCR and 100% sequence identity with a partial sequence of the P. kuehnii 28S ribosomal RNA gene, accession GU058010 (932/932 base pairs, GenBank Accession No. KF202306). Based on urediniospore morphology, DNA amplification, and sequence analysis, the causal agent of the rust observed in Ecuador was confirmed to be P. kuehnii. Commercial varieties have not yet shown symptoms of infections. However, a survey conducted in 2011 and 2012 showed an increase of disease severity from 3% to 28% in the susceptible cv. SP79-2233. Disease symptoms were evident from stalk growth to maturity (7 to 12 months), especially at the beginning of the harvesting season. To our knowledge, this is the first report of the presence, distribution, and disease spread by the sugarcane orange rust pathogen P. kuehnii in Ecuador. References: (1) M. C. Aime. Mycoscience 47:112, 2006. (2) J. C. Comstock et al. Plant Dis. 92:175, 2008. (3) J. C. Comstock et al. ASSCT. 29:82, 2009. (4) L. Dixon and L. Castlebury. Orange Rust of Sugarcane – Puccinia kuehnii. Syst. Mycol. Microbiol. Lab. Retrieved from /sbmlweb/fungi/index.cfm, August 12, 2011. (5) N. C. Glynn et al. Plant Pathol. 59:703, 2010.
Stable Carbon Isotope Discrimination Is under Genetic Control in the C4 Species Maize with Several Genomic Regions Influencing Trait Expression
Authors: Gresset Sebastian , Westermeier Peter , Rademacher Svenja , Ouzunova Milena , Presterl Thomas , Westhoff Peter , Schön Chris-Carolin 
Published: November 2013

AbstractIn plants with C4 photosynthesis, physiological mechanisms underlying variation in stable carbon isotope discrimination (Ɗ13C) are largely unknown, and genetic components influencing Ɗ13C have not been described. We analyzed a maize (Zea mays) introgression library derived from two elite parents to investigate whether Ɗ13C is under genetic control in this C4 species. High-density genotyping with the Illumina MaizeSNP50 Bead Chip was used for a detailed structural characterization of 89 introgression lines. Phenotypic analyses were conducted in the field and in the greenhouse for kernel Ɗ13C as well as plant developmental and photosynthesis-related traits. Highly heritable significant genetic variation for Ɗ13C was detected under field and greenhouse conditions. For several introgression library lines, Ɗ13C values consistently differed from the recurrent parent within and across the two phenotyping platforms. Ɗ13C was significantly associated with 22 out of 164 analyzed genomic regions, indicating a complex genetic architecture of Ɗ13C. The five genomic regions with the largest effects were located on chromosomes 1, 2, 6, 7, and 9 and explained 55% of the phenotypic variation for Ɗ13C. Plant development stage had no effect on Ɗ13C expression, as phenotypic as well as genotypic correlations between Ɗ13C, flowering time, and plant height were not significant. To our knowledge, this is the first study demonstrating Ɗ13C to be under polygenic control in the C4 species maize.
MAIGO5 Functions in Protein Export from Golgi-Associated Endoplasmic Reticulum Exit Sites inArabidopsis
Authors: Takagi Junpei , Renna Luciana , Takahashi Hideyuki , Koumoto Yasuko , Tamura Kentaro , Stefano Giovanni , Fukao Yoichiro , Kondo Maki , Nishimura Mikio , Shimada Tomoo , Brandizzi Federica , Hara-Nishimura Ikuko 
Published: November 2013

AbstractPlant cells face unique challenges to efficiently export cargo from the endoplasmic reticulum (ER) to mobile Golgi stacks. Coat protein complex II (COPII) components, which include two heterodimers of Secretory23/24 (Sec23/24) and Sec13/31, facilitate selective cargo export from the ER; however, little is known about the mechanisms that regulate their recruitment to the ER membrane, especially in plants. Here, we report a protein transport mutant of Arabidopsis thaliana, named maigo5 (mag5), which abnormally accumulates precursor forms of storage proteins in seeds. mag5-1 has a deletion in the putative ortholog of the Saccharomyces cerevisiae and Homo sapiens Sec16, which encodes a critical component of ER exit sites (ERESs). mag mutants developed abnormal structures (MAG bodies) within the ER and exhibited compromised ER export. A functional MAG5/SEC16A–green fluorescent protein fusion localized at Golgi-associated cup-shaped ERESs and cycled on and off these sites at a slower rate than the COPII coat. MAG5/SEC16A interacted with SEC13 and SEC31; however, in the absence of MAG5/SEC16A, recruitment of the COPII coat to ERESs was accelerated. Our results identify a key component of ER export in plants by demonstrating that MAG5/SEC16A is required for protein export at ERESs that are associated with mobile Golgi stacks, where it regulates COPII coat turnover.