bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study
Authors: Blot Stijn , Koulenti Despoina , Akova Murat , Bassetti Matteo , De Waele Jan J , Dimopoulos George , Kaukonen Kirsi-Maija , Martin Claude , Montravers Philippe , Rello Jordi , Rhodes Andrew , Starr Therese , Wallis Steven C , Lipman Jeffrey , Roberts Jason A 
Published: May 2014

Abstract
Introduction
The objective of this study was to describe the pharmacokinetics of vancomycin in ICU patients and to examine whether contemporary antibiotic dosing results in concentrations that have been associated with favourable response.

Methods
The Defining Antibiotic Levels in Intensive Care (DALI) study was a prospective, multicentre pharmacokinetic point-prevalence study. Antibiotic dosing was as per the treating clinician either by intermittent bolus or continuous infusion. Target trough concentration was defined as ≥15 mg/L and target pharmacodynamic index was defined as an area under the concentration-time curve over a 24-hour period divided by the minimum inhibitory concentration of the suspected bacteria (AUC0–24/MIC ratio) >400 (assuming MIC ≤1 mg/L).

Results
Data of 42 patients from 26 ICUs were eligible for analysis. A total of 24 patients received vancomycin by continuous infusion (57%). Daily dosage of vancomycin was 27 mg/kg (interquartile range (IQR) 18 to 32), and not different between patients receiving intermittent or continuous infusion. Trough concentrations were highly variable (median 27, IQR 8 to 23 mg/L). Target trough concentrations were achieved in 57% of patients, but more frequently in patients receiving continuous infusion (71% versus 39%; P = 0.038). Also the target AUC0–24/MIC ratio was reached more frequently in patients receiving continuous infusion (88% versus 50%; P = 0.008). Multivariable logistic regression analysis with adjustment by the propensity score could not confirm continuous infusion as an independent predictor of an AUC0–24/MIC >400 (odds ratio (OR) 1.65, 95% confidence interval (CI) 0.2 to 12.0) or a Cmin ≥15 mg/L (OR 1.8, 95% CI 0.4 to 8.5).

Conclusions
This study demonstrated large interindividual variability in vancomycin pharmacokinetic and pharmacodynamic target attainment in ICU patients. These data suggests that a re-evaluation of current vancomycin dosing recommendations in critically ill patients is needed to more rapidly and consistently achieve sufficient vancomycin exposure.
Die another way – non-apoptotic mechanisms of cell death
Authors: Tait Stephen W. G. , Ichim Gabriel , Green Douglas R. 
Published: May 2014

ABSTRACTRegulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during embryogenesis, development of the immune system and destruction of damaged cells. The best-studied form of programmed cell death is apoptosis, a process that requires activation of caspase proteases. Recently it has been appreciated that various non-apoptotic forms of cell death also exist, such as necroptosis and pyroptosis. These non-apoptotic cell death modalities can be either triggered independently of apoptosis or are engaged should apoptosis fail to execute. In this Commentary, we discuss several regulated non-apoptotic forms of cell death including necroptosis, autophagic cell death, pyroptosis and caspase-independent cell death. We outline what we know about their mechanism, potential roles in vivo and define outstanding questions. Finally, we review data arguing that the means by which a cell dies actually matters, focusing our discussion on inflammatory aspects of cell death.
Dispersed RhMo Nanoclusters Prepared from Oxide-supported Rh2Mo Heterometallic Complexes as Catalysts for Alcohol Oxidation
Authors: Muratsugu Satoshi , Tajima Shunichi , Tada Mizuki 
Published: May 2014

Abstract
Oxide-supported heterometallic complex structures were prepared by the impregnation of three different oxide supports with [Rh2Mo(η5-C5Me5)2(S2C6H4)2(CO)2] through a CO exchange reaction with surface hydroxy groups. The original structural framework of the heterometallic complex with two Rh–Mo heterometal bonds was maintained on SiO2 and γ-Al2O3, while the original complex structure was not maintained on TiO2; these structures were investigated by FT-IR, DR-UV–vis spectroscopy, and Mo/Rh K-edge EXAFS. Highly dispersed RhMo nanoclusters were obtained by heating the oxide-supported complexes in vacuum followed by treatment with H2 at 773 K. The RhMo nanoclusters on TiO2 exhibited the highest activity for the oxidation of benzyl alcohol with O2.
Silicon Nitride Nanorings: Synthesis and Optical Properties
Authors: Du Hongli , Zhang Wei , Li Yan 
Published: May 2014

Abstract
A facile chemical vapor deposition (CVD) method has been successfully developed to synthesize silicon nitride (Si3N4) nanorings without the use of an additive. The whole process involved only two steps of ball-milling and high-temperature calcination. The as-synthesized nanorings with an average diameter of 2–10 µm had a crystalline Si3N4 core and an amorphous SiO2 shell. The optical property measurements showed that the nanorings had an optical band gap of 4.85 eV and could emit a broad peak at 412 nm (3.0 eV).
Environmental Externalities and Cost of Capital
Authors: Chava Sudheer 
Published: May 2014

Ianalyze the impact of a firm's environmental profile on its cost of equity and debt capital. Using implied cost of capital derived from analysts' earnings estimates, I find that investors demand significantly higher expected returns on stocks excluded by environmental screens (such as hazardous chemical, substantial emissions, and climate change concerns) compared to firms without such environmental concerns. Lenders also charge a significantly higher interest rate on the bank loans issued to firms with these environmental concerns. I provide evidence that the environmental profile of a firm is not simply proxying for an omitted component of its default risk. Further, firms with these environmental concerns have lower institutional ownership and fewer banks participate in their loan syndicate than firms without such environmental concerns. These results suggest that exclusionary socially responsible investing and environmentally sensitive lending can have a material impact on the cost of equity and debt capital of affected firms. This paper was accepted by Brad Barber, finance.
El Nuevo Livro do Desassossego de Jerónimo Pizarro
Authors: Giménez Diego 
Published: May 2014

Recensión de Jerónimo Pizarro, Livro do Desassossego, Lisboa, Edição Tinta-da-china, 2013, 607 pp. ISBN 978-989-671-180-1DOI: http://dx.doi.org/10.14195/2182-8830_1-2_11
Os Filmes (D)escritos de Ana Teresa Pereira: Nightmare, de Alfred Hitchcock, e The Double, de David Cronenberg
Authors: Reis Amândio Pereira 
Published: May 2014

A partir de uma comparação inicial com um texto ecfrástico de Calístrato (séc. III), e apoiando-nos em seguida em vários estudos sobre a écfrase como prática literária, desde a Antiguidade até ao presente, e até à sua aceitação enquanto género literário intermedial, é nosso objetivo refletir sobre dois contos particulares de Ana Teresa Pereira que encenam a apresentação de filmes inexistentes de Hitchcock e Cronenberg. Para tal, passaremos tanto por um leque de problemas associados à descrição ecfrástica – tais como a dialética entre realidade e ficção, verdade e falsidade, e imaginação e leitura – e às (im)possibilidades da representação por palavras e/ou imagens, como por um conjunto de questões levantadas pela específica relação inter(/trans)medial que os textos de A. T. Pereira estabelecem entre a Literatura e o Cinema. Atentaremos ainda ao conceito de “filme escrito” (Pavle Levi) como uma hipótese, entre outras, de identificação genológica destas narrativas.Abstract Starting with a comparative reading of an ekphrastic text by Callistratus (3rd century AD) and taking support from various studies on ekphrasis as a literary practice, from antiquity to present times until its acceptance as an intermedial literary genre, it is our goal to analyze two short stories by Ana Teresa Pereira which invent non-existent films by Hitchcock and Cronenberg. Therefore, we will have to confront a range of problems associated with ekphrastic description – the dialectic between reality and fiction; truth and falsity; imagination and reading – and with the (im)possibilities of representation through image and/or words, including a set of questions posed by the specific transmedial relation that A. T. Pereira’s texts establish between Literature and Cinema. We will also take into account the concept of Pavle Levi’s “written film” as one possibility, among others, of genre identification for these narratives. DOI: http://dx.doi.org/10.14195/2182-8830_1-2_2
As Superfícies Raras da Escrita de Ruy Duarte de Carvalho
Authors: Miceli Sonia 
Published: May 2014

Neste artigo, examino as formas como literatura e cinema interagem na obra de Ruy Duarte de Carvalho, centrando a análise na escrita cinematográfica dos poemas de sinais misteriosos… já se vê… e do romance Os papéis do Inglês. Nestes textos, a imagem cinematográfica surge ora como cópia estranha do real, ora como visão criadora de outras realidades, ora como algo ligado à memória. O cinema, com os seus componentes visuais e sonoros, opera um questionamento dos limites da linguagem literária, ao passo que proporciona novas possibilidades para a poesia e para a narrativa que se configuram no confronto com e a partir dele.AbstractIn this article, I examine the ways in which literature and cinema interact in the work of Ruy Duarte de Carvalho, focusing on the cinematic writing of the poems of sinais misteriosos… já se vê… and the novel Os papéis do Inglês. In these texts, the cinematic image sometimes appears as a strange copy of reality, other times as a vision that creates other realities, and other times as something connected to memory. Cinema, with its visual and sound components, challenges the limits of literary language. At the same time it provides new possibilities for poetry and narrative, which emerge from their encounter with the language of cinema. DOI: http://dx.doi.org/10.14195/2182-8830_1-2_3
Narração e Storytelling em Mysterious Object at Noon, de Apichatpong Weerasethakul
Authors: Bértolo José 
Published: May 2014

Este texto propõe uma leitura de Mysterious Object at Noon (Apichatpong Weerasethakul, 2000), considerando questões de narração suscitadas pelo lugar central que o ato de storytelling ocupa no filme. Equacionam-se problemas tais como a ausência de texto prévio (argumento) e a atribuição de ordem ao filme pela narração oral, in loco, como se este se escrevesse à medida que vai sendo contado. Atentar-se-á em como, estruturando-se deste modo, o filme reflete sobre a especificidade do cinema enquanto máquina narrativa.AbstractThis essay is a close analysis of Mysterious Object at Noon, directed by Apichatpong Weerasethakul, in which are considered questions of narration motivated by the central place the act of storytelling holds in the film structure. Problems such as the nonexistence of a script and the way the film seems structured by oral narration, in loco, as if the film were being written as it is told, will be analyzed. Finally, I describe how, through this structure, the film reflects upon the specificity of cinema as a way of telling/showing stories. DOI: http://dx.doi.org/10.14195/2182-8830_1-2_4
Aballay, el hombre sin miedo: Um Western Borgeano
Authors: Medeiros Rosângela Fachel de 
Published: May 2014

Aballay, el hombre sin miedo (2010), de Fernando Spiner, tradução cinematográfica do conto “Aballay”, de Antonio Di Benedetto (escrito entre 1975 e 1976), parte do texto para rearticular elementos da Gauchesca argentina, presentes na literatura e no cinema, a elementos do Western, clássico e spaghetti, em um jogo de transculturação. Este artigo apresenta as duas versões de Aballay, conto e filme, para analisar as relações que essas obras estabelecem com as tradições que são revisitadas pelo cineasta no processo de realização do filme. E, sendo esta análise norteada pela percepção de que o fazer cinematográfico de Spiner é borgeano na forma e no conteúdo, a obra Jorge Luis Borges surge como intertexto teórico e narrativo.AbstractSix Shooters (2010), by Fernando Spiner, a cinematic translation of the short story "Aballay" by Antonio Di Benedetto (written between 1975 and 1976), uses the text as a starting point for articulating elements of the Argentine gauchesque, in literature and in cinema, with elements of Western, classic and Spaghetti, in a game of transculturation. This paper presents the two versions of Aballay, short story and film, in order to analyze the relationships that are established between these works and the traditions revisited by the filmmaker in the process of making the film. Considering that my analysis is guided by an understanding that Spiner’s filmmaking is Borgian in form and in content, the work of Jorge Luis Borges emerges as theoretical and narrative intertext. DOI: http://dx.doi.org/10.14195/2182-8830_1-2_5
Canine Mammary Tumours - Clinical Survey
Authors: Petrov Elena Atanaskova , Ilievska Ksenija , Trojacanec Plamen , Celeska Irena , Nikolovski Goran , Gjurovski Ivica , Dovenski Toni 
Published: May 2014

Abstract
Mammary tumours are the second most frequent neoplasia in dogs, mainly affecting older female patients. Approximately 50% of the mammary tumours are malignant with high percentage of mortality, if not treated in time. The aim of this study was to analyze the data of canine patients with mammary tumours, to evaluate the type of tumours, as well as the relationship between tumour incidence and dogs’ age, reproductive cycle and sterilization. The survey was used to retrieve the information in the period of two years from the patient data base of the University Veterinary Hospital at the Faculty of veterinary medicine in Skopje. Patients included in this survey were subjected to routine clinical investigation and additional laboratory tests (cytological examination, x-rays imaging, CBC and biochemical profile, histopathology of the tumor samples). Aged female patients (12 - 13 years) are the most susceptible category for development of mammary tumours. The reproductive history showed that five of the patients with malignant mammary tumours have never whelped and were not treated with any exogenous hormones. Malignant tumours (adenocarcinoma) were diagnosed in 90% of the patients. Three patients died due to lung metastasis. Late diagnosis is one of the major problems that results in lethal outcome due to lung metastases. Since ovarian steroids play an important role in the aetiology, the most effective prevention of mammary tumours is elective ovariectomy of the bitch at an early age.
Effects of Reclaimed Asphalt Pavement on Hot-mix Asphalt
Authors: Islam Md Rashadul , Mannan Umme A. , Rahman ASM A. , Tarefder Rafiqul A. 
Published: May 2014

Abstract
This study examined the effects of reclaimed asphalt pavement (RAP) on the structural properties and performance of hot-mix asphalt (HMA) and the rheological properties of asphalt binder in the laboratory. As a first step, dynamic modulus (|E*|) and indirect tensile strength (ITS) tests were conducted on a set of HMA samples prepared with RAP and a set of HMA samples without RAP. The moisture susceptibility of samples with and without RAP was evaluated based on the |E*| ratio of wet to dry conditioned samples. Bending beam rheometer tests and direct tension tests were conducted on virgin binder, extracted binder, and RAP and aggregate mastics (mixture of binder and RAP and aggregate passing #200 to #50 sieves) to evaluate the low-temperature cracking. The results show that RAP materials caused an increase in |E*| and a decrease in ITS and had a negligible effect on moisture susceptibility. The RAP samples produced 15 % less permanent strain in |E*| testing than samples without RAP, which means that the RAP mixes were less susceptible to rutting. However, RAP mixed binder was more susceptible to low-temperature cracking as measured by the m-value (slope of the curve of stiffness versus time) and brittleness.
Low Temperature Tensile Characteristics of Warm-Mix Asphalt Mixtures
Authors: Yeon Kyu-Seok , Kim Sungun , Lee Hyong-Jong , Kim Kwang W. 
Published: May 2014

Abstract
The tensile strength (St) of warm-mix asphalt (WMA) and hot-mix asphalt (HMA) concretes were measured by indirect tensile strength test at 25, 5, −5, −15, −25 and −35°C. Fracture toughness (Tu) was calculated from each of the St test curves. Two WMA additives and two polymer modifiers were used to produce WMA mixtures at 135°C in the laboratory. All asphalt concretes evaluated in this study showed St increase by temperature decreases, peaking at −15°C or −25°C, then decreasing with further lowering of temperatures. The St values of WMA mixtures were observed to be higher than those of HMA mixtures in most cases at all low temperatures evaluated in this study. After being subjected to differential thermal contraction damage at −15 and/or −20°C, most of the WMA mixtures showed higher St than HMA mixes at severely low temperatures (−25 and −35°C). Therefore, it was concluded that the WMA mixtures had stronger St than HMA mixtures at low temperatures when prepared with the same low-temperature PG binders, even though they were produced at a lower aggregate-heating temperature.
Mechanical Properties Assessment of Concrete Containing Reclaimed Asphalt Pavement Using the Superpave Indirect Tensile Strength Test
Authors: Su Yu-Min , Hossiney Nabil , Tia Mang , Bergin Michael 
Published: May 2014

Abstract
Concrete mixes containing reclaimed asphalt pavement (RAP) were evaluated by the Superpave Indirect Tensile (IDT) strength test. The IDT strength and elastic modulus from Superpave IDT strength test correlated well with the splitting tensile strength and elastic modulus from the conventional concrete tests. Toughness determined by the area under the stress-strain plot up to the maximum stress was found to be capable of differentiating concretes containing different percentage of RAP. The IDT strengths of concrete were seen to decrease as the percentage of RAP and temperature increased. The addition of RAP in concrete noticeably reduced the elastic modulus but increased the toughness.
Quantification of the Structural Stresses in Steel Bridges by Means of the X-Ray Diffraction Technique: The Case of the Bizkaia Bridge (Industrial World Heritage Site in Spain)
Authors: Sánchez-Beitia S. , Barrallo J. 
Published: May 2014

Abstract
One of the most interesting challenges for the scientific community in the field of structural analysis is the development of new non-destructive experimental techniques (NDT). The research presented in this report addresses the applicability of the X-ray diffraction technique for quantification of the on-site stresses in metallic (steel) structures using standard portable equipment. The paper describes the process of obtaining the structural stresses in two zones of the Bizkaia Bridge (Industrial World Heritage), which is located in the Bizkaia province (Spain) between the towns of Portugalete and Las Arenas. In a few cases, applications of the technique have been performed before. The quality of the experimental technique, as well as the usefulness of the on-site methodology in the framework of historical constructions, is presented.
The Cyclic Strain Resistance, Stress Response, Fatigue Life, and Fracture Behavior of a High Performance Alloy Steel
Authors: Manigandan K. , Srivatsan T. S. , Tammana D. , Poorganji B. , Vasudevan V. K. 
Published: May 2014

Abstract
In this paper, the results of a recent study aimed at understanding the role of microstructure on cyclic stress response, cyclic strain resistance, deformation, fatigue life, and fracture behavior of the high strength alloy steel PremoMet 290 is presented and discussed. The cyclic strain amplitude-controlled fatigue properties, deformation, and resultant fracture behavior of the alloy steel specimens are discussed when cyclically deformed over a range of strain amplitudes. The intrinsic mechanisms governing stress response, stress versus strain response fatigue life, deformation, and final fracture behavior are presented and discussed in light of the competing and mutually interactive influences of intrinsic microstructural effects, deformation characteristics of the microstructural constituents, cyclic strain amplitude, and concomitant response stress.
Application of Automation Technology in Fatigue and Fracture Testing and Analysis
Authors: McKeighan Peter C. , Braun Arthur A. 
Published: May 2014

Description
These eleven papers emphasize refined experimental methods, new methods and techniques, data analysis and software development.
The common thread throughout these papers is the increasing role of computer automation while performing the test and then interpreting the results once testing is complete. Test automation remains a critical area for developing the tools and techniques required to understand the more difficult problems that face the materials engineer and designer today.
The Automation Task Group within ASTM E08.03, the contributors to this collection of technical papers, revisit the automation research approximately every five years to report and track how testing methods, techniques and tools evolve. Recent efforts on algorithm development promise to provide useful tools to the analyst for interpreting material behavior and coping with the vast amount of data that is typically recorded in the laboratory today.
Employer Support for Innovative Work and Employees' Job Satisfaction and Job‐related Stress
Authors: Raykov Milosh 
Published: May 2014

Employer Support for Innovative Work and Employees' Job Satisfaction and Job‐related Stress: Milosh RAYKOV. Faculty of Education, University of Malta, Malta—ObjectivesThere are high levels of global and national underemployment, but limited information is available on the impact of this phenomenon on the quality of employees' working lives. This study examines the relations among perceived employer support for creative work, different forms of underemployment and employee quality of life, including job satisfaction, perceived job security and job satisfaction.MethodsThe study was performed using cross‐sectional data from the Canadian 2010 Work and Lifelong Learning Survey (WALL), which included 1,042 randomly selected currently employed participants between the ages of 18 and 64 years of age.ResultsThe study found a significant inverse association between employer support for innovative work and different forms of underemployment. It also suggested a strong relationship between support for such work and participation in work‐related informal learning. The results from this study confirmed the hypothesis that employer support for creative work is significantly associated with the quality of employees' working lives, as manifested through increased job security and job satisfaction. Employees experiencing greater support for workplace creativity report less job‐related stress. The present study identified relatively low employer support for creative work and significant differences in the perception of support among managers and workers.ConclusionsThe results of this study indicate that employer support for innovative work can mitigate significant underutilization of employee knowledge and skills. Such support can contribute to the reduction of job‐related stress, increased job satisfaction and perceived job security. This kind of support can also improve the quality of life of employees and facilitate creativity and overall organizational and social development.