bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth and life history of freshwater chelydrid turtles (Testudines: Cryptodira): A bone histological approach
Authors: Bhat Mohd Shafi , Cullen Thomas M. 
Published: August 2024

AbstractThe current study examines the growth pattern and lifestyle habits of the freshwater snapping turtles Chelydra and Macrochelys based on limb bone histology. Femora, humeri, and tibiae of 25 individuals selected from a range of ontogenetic stages were assessed to determine inter‐element and intraskeletal histological variation. Osteohistological assessment of multiple elements is consistent with overall moderate growth rates as revealed by the dominance of parallel‐fibered bone. However, the growth was cyclical as shown by deposition of multiple lines of arrested growths in the compacta. It appears that the bone tissue of C. serpentina is more variable through ontogeny with intermittent higher growth rates. M. temminckii appears to grow more slowly than C. serpentina possessing compact and thick cortices in accordance with their larger size. Overall, vascularization decreases through ontogeny with humeri and femora being well‐vascularized in both species. Contrarily, epipodials are poorly vascularized, though simple longitudinal and radial canals are present, suggesting differences in growth patterns when compared with associated diaphyseal sections. The tibiae were found to be the least remodeled of the limb bones and therefore better suited for skeletochronology for snapping turtles. Intra‐elementally, femora and humeri preserved higher cortical vascularity ventrally, suggestive of faster relative growth. We hypothesize that the differential growth pattern in limb bones of snapping turtles may relate to differential functional constraints, where forelimbs are operational in swimming while the hindlimbs provide stability.
‘Distant but close’: Leadership behaviours, psychological distance, employee coping and effectiveness in remote work contexts
Authors: Marstand Anders Friis , Epitropaki Olga , Kapoutsis Ilias 
Published: August 2024

AbstractDrawing on construal level and conservation of resources theories, our paper focuses on the psychological distance employees experience from their manager in remote work contexts. We specifically examine the role of three leadership behaviours (initiating structure, consideration and vision communication) on employees' perceptions of psychological distance from their manager and the subsequent effects on employee task, emotion and avoidance coping and individual effectiveness outcomes. Using data from two independent studies (Study 1: a four‐wave time‐lagged online study of remotely working 338 participants; Study 2: a four‐wave time‐lagged study of 202 hybrid working professionals), we found that consideration and vision communication reduced employees' perceptions of psychological distance from their manager, while psychological distance decreased task coping. Support for a serial mediation model was also found, with consideration and vision communication indirectly influencing task performance and consideration indirectly influencing organizational citizenship behaviours and withdrawal behaviours via psychological distance and then via task coping. Our research results provide new insights into the role of leadership in remote work contexts and highlight the implications of psychological distance from the leader for employees' coping responses and individual effectiveness.
Mycena citricolor isolates from diverse hosts in Costa Rica: Colony aspect, growth dynamics, reproduction in vitro and aggressiveness on Coffea arabica
Authors: Granados‐Montero Milagro , Ureña Natalia , Castro‐Tanzi Sebastián , Avelino Jacques 
Published: August 2024

AbstractThe basidiomycete fungus Mycena citricolor hosts on about 80 plant families. The asexual morph causes the disease known as American leaf spot of coffee (Coffea arabica). We isolated and characterized 15 isolates of M. citricolor collected from coffee plants, shade trees and weeds. Cultures on potato‐dextrose‐agar + yeast extract (PDAY) medium were kept for a week in complete darkness. The cultures were then exposed to light for 7 weeks and co‐cultivated with coffee foliar discs, to stimulate the production of gemmifers. We evaluated the speed of growth, appearance, colour of the mycelium and gemmifers production capacity. All isolates conformed to the typical cultural characteristics of M. citricolor, with beige/white thin and slightly aerial mycelium. The whitest isolate was from Persea americana, which had the slowest growth rate in vitro (6.4 mm/day), while the isolate from weed Kalanchoe pinnata was the fastest, with a speed of 9 mm/day. The most gemmifer‐producing isolates were those isolated from the coffee cultivar Catimor‐Costa Rica 95, Citharexylum donnell‐smithii and Cissus verticillata, with over 200 gemmifers per Petri dish. Isolates from Erythrina and Ipomoea nil produced <50 gemmifers on average. The Composite Aggressiveness Index (CAI) was determined on 2‐year‐old detached coffee branches of the Caturra variety foliage. The least aggressive isolate was from Erythrina poeppigiana (CAI = 0) and the most aggressive was from Kalanchoe pinnata (CAI = 18.87). The isolate from the coffee cultivar Catimor‐Costa Rica 95 was more aggressive than that from the cultivar Caturra (CAI = 9.94 vs. CAI = 3.66). Moreover, successful infection occurred only when the apex of gemmae made direct contact with the coffee leaf when using the inoculum derived from C. verticillata and Anredera cordifolia. These results show the variability in the population of the pathogen. This is the first study that characterizes the growth, morphology, reproduction and aggressiveness of M. citricolor obtained from hosts other than coffee. In addition, it is the first to report the use of coffee foliar discs to induce gemmifer production in vitro and to assess and quantify the effect of gemma position when inoculating coffee leaves.
What happens when the insecticide does not kill? A review of sublethal toxicology and insecticide resistance in triatomines
Authors: Mougabure‐Cueto Gastón , Fronza Georgina , Nattero Julieta 
Published: August 2024

AbstractChagas disease is considered one of the most important human parasitosis in the United States. This disease is mainly transmitted by insects of the subfamily Triatominae. The chemical vector control is the main tool for reducing the incidence of the disease. However, the presence of triatomines after pyrethroids spraying has been reported in some regions, as in the case of Triatoma infestans in Argentina and Bolivia. The presence of insects can be explained by the colonization from neighbouring areas, the reduction of insecticide dose to sublethal levels due to environmental factors, and/or by the evolution of insecticide resistance. In the last two scenarios, a proportion of the insects is not killed by insecticide and gives rise to residual populations. This article focuses on the toxicological processes associated with these scenarios in triatomines. Sublethal doses may have different effects on insect biology, that is, sublethal effects, which may contribute to the control. In addition, for insect disease vectors, sublethal doses could have negative effects on disease transmission. The study of sublethal effects in triatomines has focused primarily on the sequence of symptoms associated with nervous intoxication. However, the effects of sublethal doses on excretion, reproduction and morphology have also been studied. Rhodnius prolixus and T. infestans and pyrethroids insecticides were the triatomine species and insecticides, respectively, mainly studied. Insecticide resistance is an evolutionary phenomenon in which the insecticide acts as a selective force, concentrating on the insect population's pre‐existing traits that confer resistance. This leads to a reduction in the susceptibility to the insecticide, which was previously effective in controlling this species. The evolution of resistance in triatomines received little attention before the 2000s, but after the detection of the first focus of resistance associated with chemical control failures in T. infestans from Argentina in 2002, the study of resistance increased remarkably. A significant number of works have studied the geographical distribution, the resistance mechanisms, the biological modifications associated with resistance, the environmental influences and the genetic of T. infestans resistant to pyrethroid insecticides. Currently, studies of insecticide resistance are gradually being extended to other areas and other species. The aim of this article was to review the knowledge on both phenomena (sublethal effects and insecticide resistance) in triatomines. For a better understanding of this article, some concepts and processes related to insect‐insecticide interactions, individual and population toxicology and evolutionary biology are briefly reviewed. Finally, possible future lines of research in triatomine toxicology are discussed.
3D‐printed zirconia orthodontic brackets: Effect of printing method on dimensional accuracy
Authors: Tang Zhi , Dai Jingtao , Yu Anlan , Li Ping , Liu Chufeng , Shen Xiaoqing 
Published: August 2024

AbstractObjectivesThis study investigated the effect of additive manufacturing (AM) methods on the slot height dimensions and accuracy of 3D‐printed orthodontic brackets.MethodsA 3D model of a standard Mclaughlin Bennett Trevisi bracket was used as a reference to print the ceramic bracket in a 90° orientation using two representative AM methods: digital light processing (DLP) and material jetting (MJ). The dimensional accuracy and slot heights were determined using a scanning electron microscope and an optical scanner. Also, all specimens were analysed using the Geomagic Control X 3D inspection software. The root mean square (RMS) values were used for trueness and precision assessment. Statistical analyses were performed using an independent sample t‐test.ResultsSlot height dimensions, trueness RMS, and precision RMS were statistically affected by different AM methods (p < .01). There was a significant difference between the different printing methods, with DLP meeting the tolerance requirements (mean slot height = 0.557 ± 0.018 mm) and MJ being slightly below them (mean slot height = 0.544 ± 0.021 mm). However, MJ significantly outperformed DLP in terms of accuracy. Among the two printing methods, MJ was associated with higher trueness (RMS = 0.025 ± 0.004 mm) and precision (RMS = 0.038 ± 0.005 mm).ConclusionsBoth tested AM methods yielded clinically acceptable outcomes, with the RMS range set to ±100 μm and the slot height tolerance established at 0.549–0.569 mm. The MJ technology achieved the highest accuracy.
A Study on Imaging Risk Factors for Hip Osteoarthritis
Authors: Wang Fan , Yuan Peng , Gong Yixin , Zhang Guohao , Li Pengcui , Jiao Qiang 
Published: August 2024

ObjectiveDue to low prevalence and few studies, the morphologic risk factors for hip osteoarthritis (HOA) in Chinese population remain unknown. The purpose of this study was to investigate the relationship between 10 radiographic parameters measured via anteroposterior pelvic X‐ray radiography and HOA in Chinese population.MethodsThirty‐three patients who required total hip arthroplasty for unilateral HOA (2017–2022) and 132 healthy individuals were selected for this case–control study. We measured 10 radiological parameters via anteroposterior pelvic X‐ray radiography, which were sharp angle, center edge angle, sourcil angle, neck shaft angle, α angle, pelvic height, pelvic width, femoral head diameter, femoral neck width, and ratio of the femoral head diameter to the femoral neck width. After measurements were obtained, logistic regression analysis was utilized to calculate the adjusted odds ratios (ORs) for confounding variables such as age, sex, and body mass index (BMI). Receiver operating characteristic (ROC) curves were utilized to determine the proportional risk contribution (PRC) of each radiographic factor.ResultsAfter adjustment for confounding factors, individuals with a larger sourcil angle (SA) (OR = 4.89, 95% CI 1.66–14.42, p = 0.004), larger α angle (OR = 4.14, 95% CI 1.53–11.23, p = 0.005), and wider femoral neck (OR = 5.27, 95% CI 1.50–18.51, p = 0.01) were found to have a greater risk of developing HOA. Among all radiographic parameters, the SA demonstrated the greatest risk contribution (PRC = 13.695%).ConclusionsRadiographic parameters correlate with the incidence of HOA. The SA is probably the most powerful of all the parameters related to HOA.
Wittgenstein in Cantor's paradise
Authors: Zahidi Karim 
Published: August 2024

AbstractThis paper offers an evaluation of Wittgenstein's critique of Cantorian set theory, illustrating his broader philosophical stance on mathematics. By emphasizing the constructed nature of mathematical theories, Wittgenstein encourages a reflective approach to mathematics that acknowledges human agency in its development. His engagement with Cantorian set theory provides valuable insights into the philosophical and practical dimensions of mathematics, urging a reconsideration of its foundations and the nature of mathematical proofs. This perspective aligns closely with the philosophy of mathematical practice, which emphasizes the human side of mathematics by its focus on mathematical practice.
The gut‐facial aging axis: A two‐sample Mendelian randomization and mediation analysis of gut microbiota, gut microbiota metabolic pathways, and blood metabolites
Authors: Yang Sha , Zhao Ying , Liu Jian , Song Jianning , Long Qingyan , Cheng Si 
Published: August 2024

AbstractBackgroundFacial aging (FA) is a complex process influenced by both genetic and environmental factors. Gut microbiota (GM), gut microbiota metabolic pathways (GMMPs), and blood metabolites (BMs) have been implicated in the regulation of FA, but the causal and mediating effects of these factors remain unclear.MethodsWe used summary‐level data from genome‐wide association studies (GWAS) of 16S rRNA gene sequencing data for GM (n = 18 340), GWAS of GMMPs (n = 7738), BMs (n = 24 925), and GWAS of FA (n = 423 999). We applied Mendelian randomization (MR) methods to estimate the causal effects of GM, GMMPs, and BMs on FA. We performed mediation analysis to quantify the proportion of the effects mediated by blood metabolites.ResultsWe identified nine genus, two phylum, two families of GM, nine GM metabolic pathways, and 73 BMs that showed potential causal effects on FA. After Bonferroni correction, three BMs remained causally associated with FA, including average number of methylene groups per double bond (β, ‐0.023; 95% CI, ‐0.032∼‐0.014; p = 3.120×10‐7) and average number of methylene groups in a fatty acid chain (β, ‐0.031; 95% CI, ‐0.045∼‐0.016; p = 2.062×10‐5), which had strong negative causal effects on FA, and ratio of bisallylic groups to total fatty acids (β, 0.023; 95% CI, 0.017∼‐0.029; p = 8.441×10‐15), which had a strong positive causal effect on FA. Mediation analysis revealed that histidine, average number of methylene groups in a fatty acid chain, and triglycerides in chylomicrons and largest VLDL particles mediated the effects of anaerofilum and/ or superpathway of Laspartate and Lasparagine biosynthesis on FA.ConclusionOur study provides novel insights into the causal and mediating effects of GM, GMMPs, and BMs on FA. These findings may have implications for the development of new strategies for preventing or delaying FA.
A bibliometric analysis of global research on microbial immune microenvironment in melanoma from 2012 to 2022
Authors: Sun Lin , Ying Jianghui , Guo Rong , Jia Lingling , Zhang Hongyi 
Published: August 2024

AbstractBackgroundMelanoma is an aggressive malignancy primarily impacting the skin, mucous membranes, and pigment epithelium. The tumor microbial microenvironment encompasses both the microorganisms inhabiting the tumor vicinity and the environmental factors influencing their interactions. Emerging evidence highlights the pivotal role of the microbial immune microenvironment in melanoma.MethodsWe conducted an extensive review of scholarly works published from 2012 to 2022, utilizing The Web of Science Core Collection. Subsequently, we employed analytical tools such as VOSviewer, CiteSpace, and the R programming language to scrutinize prevailing research patterns within this domain.ResultsA sum of 513 articles were pinpointed, with notable input coming from the United States and China. Harvard University stood out as the top‐contributing institution, while the journal Science received the most citations. Current research within this sphere chiefly focuses on two principal domains: the gut microbiota and the PD‐L1 pathway concerning melanoma treatment.ConclusionThe study offers an extensive analysis and overview of the worldwide research landscape concerning the immune microenvironment with a focus on microbes in melanoma. It underscores the promising prospects for harnessing the microbial immune microenvironment's potential in melanoma. These findings furnish valuable insights and guidance for advancing scientific inquiry and refining clinical approaches within this dynamic field.
Whisper words of wisdom: Asides and appositives in Kaplan's logic of demonstratives
Authors: Predelli Stefano 
Published: August 2024

AbstractThis paper is grounded on an exegetically creative reading of Kaplan's late approach to dthat‐terms. I do have a few exegetic pretensions. In particular, I simply assume what I take to be the central tenets of Kaplan's theory of demonstratives between 1977 and 1989, and I develop them according to ideas suggested by certain passages in Afterthoughts. But my developments are also unashamedly creative. I recognize that I may overemphasize a few carefully chosen snippets and that, in doing so, I may end up ignoring other important junctures. But I happily trade textual faithfulness for theoretical insight: if on the right track, my results hopefully cast a new light not only on Kaplan's take on ‘dthat’ but also on the fundamental ideas in his philosophical and semantic framework.
Impact of 10% Dose Reductions and Duration of Treatment Delays in the Management of Chemotherapy‐Induced Neutropenia in Dogs Treated With Common Chemotherapy Protocols: A Single‐Centre Experience
Authors: Busser Suzanne , Blackwood Laura , Pereira Constanza , Chase‐Topping Margo , Bavcar Spela , Fournier Quentin 
Published: August 2024

ABSTRACTNeutropenia is a common chemotherapy‐associated adverse event (AE) in dogs and a significant cause of decreased relative dose intensity. Dose reductions (DRs) and treatment delays (TDs) are frequently applied to decrease the risk of further neutropenic events (NEs) and AEs, but there is no standardised approach. The two main objectives of this retrospective study were to determine: (1) the failure rate of a 10% DR to prevent a subsequent inadequate absolute neutrophil count (ANC), defined as a nadir ANC <0.75 × 109/L or pretreatment ANC <1.5 × 109/L; and (2) if the duration of TDs due to pretreatment neutropenia affects the occurrence of subsequent NEs. A total of 1056 chemotherapy treatments were recorded for 128 dogs that developed at least one NE. In 75 of 124 (60.5%, 95% CI: 51.2%–69%) evaluable NEs, a nadir ANC of ≥0.75 × 109/L and pretreatment ANC of ≥1.5 × 109/L were achieved after a single 10% chemotherapy DR, while a 10% DR failed to prevent a subsequent inadequate ANC in the remaining 49/124 (39.5%, 95% CI: 30.1%–48.3%). The only variable associated with failure was the drug prescribed. DR failure occurred in 22/39 (56.4%, 95% CI: 40.9%–70.6%) lomustine DRs, 14/27 (51.9%, 95% CI: 33.9%–69.2%) cyclophosphamide DRs, but only 2/22 (9.1%, 95% CI: 2.5%–27.8%) doxorubicin DRs and 2/24 (8.3%, 95% CI: 2.3%–25.8%) vincristine DRs. Seventy‐three evaluable TDs (mean: 5 days, SD ± 2.2 days) were prescribed. There was no association between TD duration and subsequent NEs (p = 0.11).
Can Caffeine Change the Game? Effects of Acute Caffeine Intake on Specific Performance in Intermittent Sports During Competition: A Systematic Review and Meta-Analysis
Authors: Diaz-Lara Javier , Nieto-Acevedo Raúl , Abian-Vicen Javier , Del Coso Juan 
Published: August 2024

Background: The benefits of oral caffeine intake to enhance several aspects of physical performance, such as aerobic endurance, strength, power, and muscle endurance performance, are well supported. However, how the physical performance benefits of caffeine supplementation are translated into better specific actions in intermittent sports during real or simulated competition has been the topic of fewer investigations, and their results need to be appropriately reviewed and meta-analyzed. Objective: The aim of the study was to investigate the effects of acute caffeine intake on specific actions in intermittent sports involving decision making and high-intensity efforts (eg, team, racket, and combat sports) during real or simulated competitions. Methods: All studies included had blinded and crossover experimental designs, and we conducted a risk-of-bias analysis. In total, we included 24 studies. A meta-analysis was performed using the random-effects model to calculate the standardized mean difference (SMD) estimated by Hedges g and 95% CIs. Results: Caffeine ingestion increased high-intensity sport-specific actions during competition, such as the number of sprints (SMD: 0.48; 95% CI, 0.23–0.74), body impacts (SMD: 0.28; 95% CI, 0.08–0.49), accelerations (SMD: 0.35; 95% CI, 0.06–0.63), decelerations (SMD: 0.63; 95% CI, 0.12–1.14), and high-intensity offensive efforts (SMD: 0.36; 95% CI, 0.11–0.61). Additionally, caffeine ingestion induced a higher positive or success rate of actions during real or simulated competition (SMD: 0.44; 95% CI, 0.19–0.69). Conclusion: The current meta-analysis provides evidence of caffeine supplementation in increasing high-intensity efforts and the success rate of sport-specific actions during real or simulated competition.
Natural history of spinal cord compression stage AFMS3 in infants with achondroplasia: retrospective cohort study
Authors: Cheung Moira Shang-Mei , Cocca Alessandra , Harvey Charlotte H , Brett Connor Stephen S , Offiah Amaka C , Borg Stephanie , Jenko Nathan , D’Arco Felice , Thompson Dominic 
Published: August 2024

Background and objective
Foramen magnum stenosis (FMS) is a common, serious complication of achondroplasia in infancy and associated with sudden infant death. The Achondroplasia Foramen Magnum Score (AFMS; 0–4) is used to classify the severity of stenosis to inform appropriate neurosurgical management. Infants with AFMS4 are referred for neurosurgery, while well children with AFMS3 undergo repeat MRI routinely after 12 months.
As the natural history of children with AFMS3 is currently unclear, the objective was to review follow-up MRI scans of infants initially classified as AFMS3 to define more clearly the evolution of this degree of stenosis.

Design
This retrospective cohort study, from two tertiary centres, included infants with a confirmed diagnosis of achondroplasia and AFMS3 on initial MRI who subsequently underwent repeat MRI or proceeded straight to neurosurgery.

Results
Twenty-two cases satisfied the inclusion criteria. Mean age in months was 6.23 (SD±3.82) and 17.95 (SD±7.68) at baseline and follow-up scans, respectively. Follow-up MRI showed no change in 23% (N=5), improvement in 36% (N=8) to either AFMS1 (N=5) or AFMS2 (N=3). There was progression in 41% to AFMS4 (N=8). One case had neurosurgey without follow-up MRI (N=1).

Conclusions
These results support MRI screening for FMS in infants with achondroplasia. Furthermore, infants with AFMS3 should undergo follow-up MRI as over 40% progress prompting neurosurgical intervention. There is currently no consensus on frequency or timing of screening for AFMS3 in achondroplasia; however, we suggest that guidance for follow-up imaging is modified to 6 months to detect progression earlier in this at-risk cohort.