bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teaching Outside One’s Race: The Story of an Oakland Teacher
Authors: Picower Bree 
Published: March 2015

“Oh, the District placed you at Prescott Elementary? You better watch out ‒ they hate white people. Especially that Carrie Secret ‒ she’s one of those black radicals, you know, the Ebonics people.” This was the warning I was given multiple times in multiple ways when people found out that I had been assigned to Prescott Elementary School for my first teaching position, in Oakland, California in 1999. The “warners” were other white folks who were trying to protect what they saw as a young, new teacher from what they perceived to be a hostile place. However, I really didn’t fit the stereotype. I had been involved with several organizations that explicitly addressed issues of race and education for several years, often as the only white person there. I was thrilled to be placed at a school such as Prescott, whose reputation for high achievement for African American children and adoption of the “Ebonics” program had placed it at the forefront of national debate.
A Radical Critique of the Learning Outcomes Assessment Movement
Authors: Bennett Michael , Brady Jacqueline 
Published: March 2015

The Learning Outcomes Assessment (LOA) movement seems rather innocuous. Teachers and administrators at colleges and universities are asked to articulate the goals, objectives, measures, and outcomes of the educational process at every level: from the classroom to the department to the institution as a whole. Educators engage in this process with the help of curriculum mapping or educational matrices or a host of other tools and templates provided by any number of readily available frameworks (see the website of the National Institute for Learning Outcomes Assessment for many examples). The information gathered is then used to evaluate curricula, programs, instructors, and institutions for purposes of internal review and external evaluation.
Assessment of Modifications in Thickness, Curvatures, and Volume upon the Cornea Caused by Disposable Soft Contact Lens Wear
Authors: Del Águila-Carrasco Antonio J. , Domínguez-Vicent Alberto , Pérez-Vives Cari , Ferrer-Blasco Teresa , Montés-Micó Robert 
Published: March 2015

Purpose To assess the effect of different disposable soft contact lenses on several corneal parameters–-thickness, anterior and posterior curvature, and volume–-by means of a Scheimpflug imaging-based device (Pentacam HR). Diurnal variations of these parameters were taken into account. Methods Twenty-one young, healthy subjects wore 4 different types of daily disposable soft contact lenses on 4 different days: Dailies AquaComfort Plus, SofLens, Dailies Total1, and Acuvue TruEye. The lenses had different material and water content. Pachymetry and curvature maps and corneal volume values were obtained using the Pentacam HR twice a day: one before putting the lens on and one after an 8-hour period of contact lens wear. Measurements were also taken without any contact lenses being worn. Results Regarding corneal thickness, the lens with the most similar behavior to the naked eye scenario was the Dailies Total1, causing a thickening of 0.2 ± 0.1% in the central zone and 0.6 ± 0.2% in the periphery. All 4 lenses caused a slight but not significant flattening in the anterior corneal curvature, whereas the posterior corneal curvature only experienced a significant but small steepening with the SofLens. The use of these lenses increased corneal volume slightly. Conclusions Variations in corneal parameters seem to depend on the type of contact lens used (material, oxygen transmissibility, water content). However, the magnitude of the changes introduced by the use of soft contact lenses over the 8-hour period was small and probably not large enough to influence either visual acuity or comfort.
Intravitreal Dexamethasone Implant for Cystoid Macular Edema and Inflammation after Scleral Buckling
Authors: Bonfiglio Vincenza , Fallico Matteo R. , Russo Andrea , De Grande Vittorio , Longo Antonio , Uva Maurizio G. , Reibaldi Michele , Avitabile Teresio 
Published: March 2015

Purpose Cystoid macular edema may occur following scleral buckling and therefore deteriorate the visual outcome. Inflammation may be the major causative factor in the development of postoperative cystoid macular edema. This case demonstrates the effectiveness of a dexamethasone implant as a treatment after the onset of choroidal inflammation and cystoid macular edema 6 months following scleral buckling and having visual acuity restored. Methods A 59-year-old phakic woman treated with scleral buckling for macula-off retinal detachment presented 2 months after surgery with cystoid macular edema with choroidal inflammation. Optical coherence tomography and fluorescein angiography were performed. From the time of the diagnosis, the patient's condition had been nonresponsive to medical therapy and only partially responsive to sub-Tenon triamcinolone acetonide. An intravitreal implant with a sustained release of 0.7 mg dexamethasone was implanted. Results Following an intravitreal injection with a dexamethasone implant, the macular edema subsided completely and optical coherence tomography showed decreased foveal thickness from 510 μm to 220 μm. Choroidal fluorescein leakage disappeared. Best-corrected visual acuity improved from 0.70 to 0.20 logMAR, a condition maintained throughout the 6 months of follow-up. Conclusions Cystoid macular edema and choroidal inflammation are difficult to treat, but the improvement observed in this case of post scleral buckling macular edema and choroidal inflammation showed how a dexamethasone implant proved to be useful during the 6-month follow-up.
Unique Genomic Profile Associated with Pediatric Uveal Melanoma
Authors: Blasi Maria Antonietta , Orteschi Daniela , Pagliara Monica M. , Coco Giulia , Asaro Alessia , Mulè Antonino , Petrone Gianluigi , Zollino Marcella 
Published: March 2015

Purpose To determine genetic features of a pediatric uveal melanoma in a 6-year-old girl by array-based comparative genomic hybridization (a-CGH) and assess prognosis, and to search for constitutional copy number variations (CNVs) encompassing oncosuppressor genes. Methods High-resolution a-CGH was performed on genomic DNA from cancer cells and from peripheral blood cells. Histopathology and clinical staging of the tumor were simultaneously assessed. Results Array-based CGH revealed no CNVs on tumor cells associated with poor prognosis; namely, no monosomy 3, losses of 1p, 6q, or 8p, and no gains of 8q. A unique genomic profile was observed, consisting mainly of partial terminal duplications affecting chromosomes 1, 4, 5, 9, 10, 11, 16, and 19, and complete trisomy of chromosomes 6, 7, and 20. The nonmetastatic tumor had predominantly epithelioid histology. No constitutional CNVs encompassing oncosuppressor genes were detected. Conclusions We report a very rare uveal melanoma characterized by low-risk genomic profile and poor prognostic histologic and clinical features. The child is relapse-free at 1-year follow-up. The unusual CNVs detected by a-CGH suggest specific pathogenic mechanisms.
Influence of the Two-Layer Preservation Method on Human Pancreatic Islet Isolation: A Meta-Analysis
Authors: Li Xiaohang , Zhang Jialin , Sang Lixuan , Chu Zhiqiang , Dong Ming 
Published: March 2015

Introduction There has been continuous debate on whether the Two-Layer Method (TLM) is superior to the University of Wisconsin solution (UW) for preserving human pancreas prior to islet isolation. The objective of the current meta-analysis is to assess which method is superior. Methods We searched electronic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials) for relevant human trials published in the English language from January 2000 to October 2013. Data on donor characteristics and islet isolation outcomes were extracted. Results 14 articles containing 18 human studies were included in this meta-analysis. In comparison to UW alone, TLM alone produced a significantly higher islet yield (weighted mean difference, 776.32; 95% confidence interval; 370.82-1181.82; P = .0002). TLM alone also yielded higher proportion of transplantable preparations (odds ratio, 1.60; 95% confidence interval; 1.15-2.23; P = .005). The following measures did not differ: islet viability (weighted mean difference, 2.10; −2.41-6.60; P = .360), purity (weighted mean difference, −0.92; −3.75-1.91; P = .520) and function assessed by measuring the stimulation index (weighted mean difference, 0.17; −0.21-0.55; P = .380). When comparing TLM following UW storage with UW alone, the results were similar to the previous ones. Conclusions This data indicates that the TLM can improve islet yield and increase the opportunities of human pancreatic islet transplantation. Therefore, the TLM should be recommended for preserving human pancreas prior to islet isolation.
Identification of Biomarkers for the Prognosis of Pancreatic Ductal Adenocarcinoma with miRNA Microarray Data
Authors: Wang Song , Zhao Yanxun , Li Dongsheng , Zhu Liangchen , Shen Zugang 
Published: March 2015

Background The aim of this study was to explore the mechanism of chemotherapy resistance and to screen biomarkers of pancreatic ductal adenocarcinoma (PDAC). Methods MicroRNA (miRNA) expression profile data for GSE38781 were downloaded from the Gene Expression Omnibus database. Differentially expressed miRNAs between short–overall survival (OS) and long-OS patients were screened with the limma package in R. The function and protein–protein interaction (PPI) network of the miRNA target genes were further investigated. Finally, multivariate statistical analysis was performed to verify the significant miRNAs obtained in our work. Results In total, 66 miRNAs were identified to be differentially expressed. Gene ontology (GO) and pathway enrichment analysis showed that 163 miRNA target genes were mainly enriched in heart function, cancer development and angiogenesis. Ten nodes, including TGFBR1, TGFBR2, ACVR1 and SHC1, were found to be hub nodes in the PPI network. Multivariate statistical analysis showed 8 of the most significant miRNAs could completely distinguish the 2 groups of samples. Seven target genes (i.e., RET, ETS1, RHOA, NUMB, TIAM, ITGA5 and YY1) of the 8 significant miRNAs were found to be associated with control of cell fate decisions, T-cell lymphoma invasion and angiogenesis enhancement. Conclusions The heart function–related pathway, cell cycle, immune system and angiogenesis may be dysregulated in patients with poorer prognosis. The significant nodes (e.g., TGFBR1, TGFBR2, ACVR1 and SHC1) in the PPI network may be potential biomarkers for predicting outcomes for patients with pancreatic cancer. The significant miRNAs and gene targets may be potential biomarkers or therapeutic targets for PDAC.
Long-term Clinical Outcome of Intensity-modulated Radiation Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma
Authors: Ge Xiaolin , Yang Xi , Lu Xiaohu , Wen Wei , Zhen Fuxi , Ye Hongxun , Zhu Hongcheng , Cao Yuandong , Zhang Sheng , Cheng Hongyan , Ma Jianxin , Yang Baixia , Dai Shengbin , Guo Qing , Cai Jing , Sun Xinchen 
Published: March 2015

Purpose This study evaluated the effectiveness and safety of intensity-modulated radiation therapy (IMRT) for locally advanced esophageal squamous cell carcinoma (ESCC). Methods Between August 2009 and December 2011, 112 patients with pathologically confirmed ESCC treated with IMRT at Jiangsu Province People's Hospital and Nantong Tumor Hospital were included in a retrospective analysis. Patients received either IMRT alone (group A) or concurrent chemoradiotherapy (CRT) (group B). A radiation dose of 60–66 Gy administered in 30–33 fractions was delivered to the tumor. The patients in group B simultaneously received 2 cycles of cisplatin-based doublets with either 5-fluorouracil or taxotere. The Kaplan-Meier method was used to compute the survival time. Early and late toxicities were scored according to CTCAE v.3.0. Results The response rate of group B (91.07%) was not significantly greater than that of group A (89.29%) (X2 = 0.10, p = 0.75). The 1- and 3-year survival rates of group B (87.5% and 57.14%, respectively) were greater than those of group A (69.64% and 37.50%, respectively). The difference in overall survival was statistically significant between groups A and B (x2 = 5.30, p = 0.02; x2 = 4.33, p = 0.04). Hematological toxicity, gastrointestinal toxicity, and treatment-related esophagitis were significantly higher in group B than group A (16.07% vs. 33.93%, p = 0.04; 10.71% vs. 26.79%, p = 0.03; 19.64% vs. 44.64%, p = 0.01). However, intergroup differences in terms of late toxicity were not significant. Conclusions IMRT was a practical and feasible technique to treat ESCC. Concurrent CRT could increase local tumor control and long-term survival. The CRT regimen was associated with a higher incidence of acute gastrointestinal and hematological toxicity.
Comparative Study of Autologous Stromal Vascular Fraction and Adipose-Derived Stem Cells for Erectile Function Recovery in a Rat Model of Cavernous Nerve Injury
Authors: You Dalsan , Jang Myoung Jin , Kim Bo Hyun , Song Geehyun , Lee Chunwoo , Suh Nayoung , Jeong In Gab , Ahn Tai Young , Kim Choung-Soo 
Published: March 2015

Abstract
The abilities of intracavernous injection of autologous stromal vascular fraction (SVF) and adipose-derived stem cells (ADSCs) to facilitate recovery of erectile function in a rat model of cavernous nerve (CN) injury were compared. Forty male Sprague-Dawley rats were randomly divided into four groups: sham and control groups (intracavernous injection of phosphate-buffered saline), SVF group (intracavernous injection of SVF), and ADSC group (intracavernous injection of ADSCs). Rats in the latter three groups underwent bilateral CN injury prior to injection. The evaluation of erectile function and histomorphometric studies were performed 4 weeks after injection. The ratio of maximal intracavernous pressure to mean arterial pressure was significantly lower in the control group than in the sham group (0.18 vs. 0.56, p &lt; .001). Intracavernous injection of SVF (0.36, p = .035) significantly improved erectile function compared with that in the control group, whereas the ADSC group (0.35, p = .052) showed marginally significant improvement. The smooth muscle/collagen ratio, smooth muscle content, number of neuronal nitric-oxide synthase-positive nerve fibers, and expression of von Willebrand factor were significantly higher in the SVF and ADSC groups than in the control group. Expression of endothelial nitric-oxide synthase was significantly increased in the SVF group. The increases in the smooth muscle/collagen ratio and von Willebrand factor expression were larger in the SVF group than in the ADSC group. Intracavernous injection of SVF or ADSCs was equally effective in recovering penile erection in a rat model of CN injury.
Science économique et bien commun : un mariage impossible ?
Authors: Vermersch Dominique 
Published: March 2015

En vouant sa prétention à la scientificité dans l’affermissement de l’autonomie morale des individus, la science économique contrecarre d’emblée non seulement la primauté mais la réalité même du bien commun. Ce faisant, elle se voit contrainte à suggérer des éthiques de substitution dont les écueils en viennent a contrario à démontrer la prégnance du bien commun ; et plus encore sa nécessité, rappelée impérieusement par la réalité même des faits économiques. S’illustre ainsi le constat sans concession de Jean-Pierre Dupuy, suivant lequel l’économie rationalise lourdement et retrouve ce que la morale a toujours su.
Finalité et affectivité
Authors: Larochelle Yves 
Published: March 2015

Charles De Koninck, qui chercha à réconcilier la lecture thomiste d’Aristote avec la science contemporaine, et Michel Henry, qui voulut rénover la phénoménologie husserlienne et heideggérienne en restituant la place de l’affectivité dans le champ philosophique, ont connu des trajectoires intellectuelles très différentes. Pourtant, leurs parcours respectifs aboutissent ultimement aux deux mêmes conclusions déterminantes : le réductionnisme scientifique ambiant menace l’intégrité spirituelle de l’humanité et seul le constat d’une finalité d’ordre divin à la vie humaine peut restituer un sain équilibre.
Outcome of Cesarean Scar Pregnancies Diagnosed Sonographically in the First Trimester
Authors: Michaels Aya Y. , Washburn Erin E. , Pocius Katherine D. , Benson Carol B. , Doubilet Peter M. , Carusi Daniela A. 
Published: March 2015

ObjectivesThe purpose of this study was to determine the outcome of cesarean scar pregnancies diagnosed during the first trimester.MethodsWe retrospectively identified all cesarean scar implantation pregnancies diagnosed by sonography before 14 weeks' gestation between 2000 and 2012 at our institution. We reviewed the patients' sonograms and medical records and recorded sonographic findings and pregnancy outcomes.ResultsThirty‐four cases met study entry criteria. Ten patients presented with no embryonic cardiac activity, of whom 7 underwent interventions, and 3 were expectantly managed. One of the former 7 and none of the latter 3 required hysterectomy for bleeding. Among the 24 patients with embryonic cardiac activity, 8 were managed expectantly: 5 (62.5%) ultimately delivered a live‐born neonate, 3 (60.0%) of whom required hysterectomy due to placenta accreta; and 3 had fetal demise. Sixteen of the 24 underwent interventions, 2 opting for gravid hysterectomy (10 and 11 weeks' gestation, respectively) and 14 treated by a minimally invasive method: intrasac potassium chloride injection (3 cases); intrasac potassium chloride injection plus intramuscular methotrexate (4 cases); sonographically guided dilation and curettage (6 cases); and laparascopic resection (1 case). None of the latter 14 subsequently required hysterectomy.ConclusionsIf a woman has a first‐trimester diagnosis of a cesarean scar implantation pregnancy and embryonic cardiac activity is present, expectant management offers the possibility of delivering a live‐born neonate (62.5% in our study) but carries a substantial likelihood of hysterectomy at delivery due to placenta accreta (37.5% in our study), whereas minimally invasive therapy that interrupts the pregnancy largely eliminates the need for hysterectomy.
Sonographic Features of Thyroid Nodules That May Help Distinguish Clinically Atypical Subacute Thyroiditis From Thyroid Malignancy
Authors: Pan Fu-shun , Wang Wei , Wang Yan , Xu Ming , Liang Jin-yu , Zheng Yan-ling , Xie Xiao-yan , Li Xiao-xi 
Published: March 2015

ObjectivesThe purpose of this study was to evaluate sonographic features for distinguishing clinically atypical subacute thyroiditis from malignant thyroid nodules.MethodsA total of 165 hypoechoic thyroid nodules without calcification in 135 patients with histologic diagnosis were included in this study. These nodules were classified into 2 groups: a thyroiditis group (55 nodules in 36 patients) and a malignancy group (110 nodules in 99 patients). The sonographic features of the groups were retrospectively reviewed.ResultsNo significant differences were detected for the variables of marked echogenicity, a taller‐than‐wide shape, and mixed vascularity. However, a poorly defined margin was detected more frequently in the thyroiditis group than the malignancy group (P < .05); it yielded a high capability for differential diagnosis of atypical subacute thyroiditis, with sensitivity and specificity of 87.3% and 80.9%, respectively. Centripetal reduction echogenicity was observed exclusively in the thyroiditis group, with high specificity (100%) but low sensitivity (21.8%) for atypical subacute thyroiditis diagnosis. All of the thyroiditis nodules with a positive color signal showed noninternal vascularity (negative predictive value, 100%).ConclusionsThere is a considerable overlap between the sonographic features of atypical subacute thyroiditis and thyroid malignancy. However, the margin, echogenicity, and vascularity type are helpful indicators for differential diagnosis of atypical subacute thyroiditis.
Future beam experiments in the magnetosphere with plasma contactors: How do we get the charge off the spacecraft?
Authors: Delzanno G. L. , Borovsky J. E. , Thomsen M. F. , Moulton J. D. , MacDonald E. A. 
Published: March 2015

AbstractThe idea of using a high‐voltage electron beam with substantial current to actively probe magnetic field line connectivity in space has been discussed since the 1970s. However, its experimental realization onboard a magnetospheric spacecraft has never been accomplished because the tenuous magnetospheric plasma cannot provide the return current necessary to keep spacecraft charging under control. In this work, we perform Particle‐In‐Cell simulations to investigate the conditions under which a high‐voltage electron beam can be emitted from a spacecraft and explore solutions that can mitigate spacecraft charging. The electron beam cannot simply be compensated for by an ion beam of equal current, because the Child‐Langmuir space charge limit is violated under conditions of interest. On the other hand, releasing a high‐density neutral contactor plasma prior and during beam emission is critical in aiding beam emission. We show that after an initial transient controlled by the size of the contactor cloud where the spacecraft potential rises, the spacecraft potential can settle into conditions that allow for electron beam emission. A physical explanation of this result in terms of ion emission into spherical geometry from the surface of the plasma cloud is presented, together with scaling laws of the peak spacecraft potential varying the ion mass and beam current. These results suggest that a strategy where the contactor plasma and the electron beam operate simultaneously might offer a pathway to perform beam experiments in the magnetosphere.
Testing astronomically tuned age models
Authors: Zeeden Christian , Meyers Stephen R. , Lourens Lucas J. , Hilgen Frederik J. 
Published: March 2015

AbstractAstrochronology is fundamental to many paleoclimate studies, but a standard statistical test has yet to be established for validating stand‐alone astronomically tuned time scales (those lacking detailed independent time control) against their astronomical insolation tuning curves. Shackleton et al. (1995) proposed that the modulation of precession's amplitude by eccentricity can be used as an independent test for the successful tuning of paleoclimate data. Subsequent studies have demonstrated that eccentricity‐like amplitude modulation can be artificially generated in random data, following astronomical tuning. Here we introduce a new statistical approach that circumvents the problem of introducing amplitude modulations during tuning and data processing, thereby allowing the use of amplitude modulations for astronomical time scale evaluation. The method is based upon the use of the Hilbert transform to calculate instantaneous amplitude following application of a wide band precession filter and subsequent low‐pass filtering of the instantaneous amplitude to extract potential eccentricity modulations. Statistical significance of the results is evaluated using phase‐randomized surrogates that preserve the power spectrum structure of the data but have randomized amplitude modulations. Application of the new testing algorithm to two astronomically tuned data sets demonstrates the efficacy of the technique and confirms the presence of astronomical signals. Additionally, it is demonstrated that a minimal tuning approach using (at maximum) one precession cycle per ~100 kyr eccentricity cycle does not introduce systematic frequency modulations, even when a narrow band‐pass filter is applied, allowing direct comparison of data amplitudes and orbital eccentricity.