bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fate and behavior of rotenone in Diamond Lake, Oregon, USA following invasive tui chub eradication
Authors: Finlayson Brian J. , Eilers Joseph M. , Huchko Holly A. 
Published: April 2014

Abstract

In September 2006, Diamond Lake (OR, USA) was treated by the Oregon Department of Fish and Wildlife with a mixture of powdered and liquid rotenone in the successful eradication of invasive tui chub Gila bicolor. During treatment, the lake was in the middle of a phytoplankton (including cyanobacteria Anabaena sp.) bloom, resulting in an elevated pH of 9.7. Dissipation of rotenone and its major metabolite rotenolone from water, sediment, and macrophytes was monitored. Rotenone dissipated quickly from Diamond Lake water; approximately 75% was gone within 2 d, and the average half-life (t½) value, estimated by using first-order kinetics, was 4.5 d. Rotenolone persisted longer (&gt;46 d) with a short-term t½ value of 16.2 d. Neither compound was found in groundwater, sediments, or macrophytes. The dissipation of rotenone and rotenolone appeared to occur in 2 stages, which was possibly the result of a release of both compounds from decaying phytoplankton following their initial dissipation. Fisheries managers applying rotenone for fish eradication in lentic environments should consider the following to maximize efficacy and regulatory compliance: 1) treat at a minimum of twice the minimum dose demonstrated for complete mortality of the target species and possibly higher depending on the site's water pH and algae abundance, and 2) implement a program that closely monitors rotenone concentrations in the posttreatment management of a treated water body. Environ Toxicol Chem 2014;33:1650–1655. © 2014 SETAC
Contaminant exposure of birds nesting in Green Bay, Wisconsin, USA
Authors: Custer Thomas W. , Dummer Paul M. , Custer Christine M. , Franson J. Christian , Jones Michael 
Published: April 2014

Abstract

In earlier studies, elevated concentrations of polychlorinated biphenyl (PCB) and p,p'-dichlorodiphenyldichloroethylene (DDE) were reported in double-crested cormorant (Phalacrocorax auritus) eggs and tree swallow (Tachycineta bicolor) eggs and nestlings collected from lower Green Bay (WI, USA) in 1994 and 1995 and black-crowned night-heron (Nycticorax nycticorax) eggs collected in 1991. Comparable samples collected in 2010 and 2011 indicated that concentrations of PCBs were 35%, 62%, 70%, and 88% lower than in the early 1990s in tree swallow eggs, tree swallow nestlings, double-crested cormorant eggs, and black-crowned night-heron eggs, respectively; concentrations of DDE were 47%, 43%, 51%, and 80% lower, respectively. These declines are consistent with regional contaminant trends in other species. Concentrations of PCBs were higher in herring gull (Larus argentatus) than in black-crowned night-heron eggs collected from Green Bay in 2010; PCB concentrations in double-crested cormorant and tree swallow eggs were intermediate. The estimated toxicity of the PCB mixture in eggs of the insectivorous tree swallow was the equal to or greater than toxicity in the 3 piscivorous bird species. A multivariate analysis indicated that the composition percentage of lower-numbered PCB congeners was greater in eggs of the insectivorous tree swallow than in eggs of the 3 piscivorous species nesting in Green Bay. Dioxin and furan concentrations and the toxicity of these chemicals were also higher in tree swallows than these other waterbird species nesting in Green Bay. Environ Toxicol Chem 2014;33:1832–1839. Published 2014 Wiley Periodicals, Inc. Published 2014 Wiley Periodicals, Inc. This article is a US Government work and, as such, is in the public domain in the USA.
Subjective sleep characteristics associated with anxiety and depression in older adults: a population‐based study
Authors: Potvin Olivier , Lorrain Dominique , Belleville Geneviève , Grenier Sébastien , Préville Michel 
Published: April 2014

ObjectiveSleep complaints are often associated with anxiety and depression, but the specific complaints related to each syndrome are poorly characterized, especially in older adults. The objective was to identify subjective sleep characteristics specific to anxiety and depression in this population.MethodsA random sample of 2393 individuals aged 65 years or older was used. Anxiety and depression were categorized using DSM‐V criteria for phobias, panic disorder, generalized anxiety disorder, unspecified anxiety disorder, major depressive episode, and depressive episode with insufficient symptoms. Subjective sleep characteristics were measured using the Pittsburgh Sleep Quality Index. Logistic regression models predicting anxiety or depression were used to determine the independent sleep characteristics associated with each syndrome adjusting for age, sex, education level, cognitive functioning, anxiolytic/sedative/hypnotic use, antidepressants use, subjective health, chronic diseases, cardiovascular conditions, and anxiety or depression (as appropriate).ResultsNearly all Pittsburgh Sleep Quality Index subscales were significantly associated with anxiety, but these subscales shared variance and only sleep duration in hours, sleep disturbance score, and daytime functioning score were independently related to anxiety. Within these significant subscales, the main specific sleep complaints associated with anxiety were daytime sleepiness and sleep disturbances related to coughing/snoring, feeling cold, and bad dreams. The use of sleeping medication was the only specific sleep characteristic associated with depression.ConclusionsThese results suggest that in older adults, symptoms of short sleep duration, daytime sleepiness and sleep disturbances are independently related to anxiety while the use of sleep medication is independently associated to depression. Copyright © 2014 John Wiley & Sons, Ltd.
Antecedents of intact cognition and dementia at age 90 years: a prospective study
Authors: Vaillant George E. , Okereke Olivia I. , Mukamal Kenneth , Waldinger Robert J. 
Published: April 2014

ObjectivesThis study aimed to examine the possible antecedents of both dementia and sustained intact cognition at age 90 years among men who underwent a prospective, multidisciplinary assessment from ages 19 to 90 years, with little attrition.MethodsWe conducted a prospective 20‐year reassessment of 196 (out of 268) former Harvard college sophomores who survived until age 70 years. Since 1939, the study gathered measurements of childhood environment, dominant personality traits, objective mental and physical health over time, smoking in pack‐years, alcohol abuse, and depression. Questionnaires were obtained every 2 years and physical exams every 5 years. Cognitive status was assessed at ages 80, 85, and 90 years.ResultsDespite addressing a wide variety of health, behavioral, and social factors over the lifespan, we observed few predictors with strong association with either intact cognition at age 90 years (n = 40) or dementia (n = 44). Univariate analysis revealed seven suggestive predictors of intact cognition at age 90 years or of dementia: warm childhood relationship with mother, exercise at age 60 years, high maternal education, young age of mother at subject's birth, low body mass index, good physical health at 60 years, and late retirement. Only the first three variables, warm childhood relationship with mother, exercise at age 60 years, and high maternal education, remained significant with logistic regression.ConclusionsIn this prospective study of long‐lived, highly educated men, several well‐known putative predictors of Alzheimer's disease did not distinguish those who over the next 20 years developed dementia from those with unimpaired cognition until age 90 years. Copyright © 2014 John Wiley & Sons, Ltd.
The utility of the Edinburgh Depression Scale as a screening tool for depression in Parkinson's disease
Authors: Baillon Sarah , Lindesay James , Prabhakaran Pravin , Hands Oli , Murray Jonathan , Stacey Suzanne , Gaur Sandhya , Rajkonwar Aniruddha , Padmanabhan Jayaraj , Shukla Deepak , Chakrabarti Santanu , Lo Nelson , Dennis Michael 
Published: April 2014

ObjectiveThis study aimed to evaluate the Edinburgh Depression Scale (EDS) as a screening tool for use in a Parkinson's disease (PD) population. Many commonly used depression scales include items relating to somatic symptoms that also occur in PD, which could potentially result in inaccurate reporting of depressive symptoms. The EDS is a scale that incorporates no somatic items.MethodOne hundred twenty patients attending specialist PD clinics were assessed using a standardised diagnostic interview (Present State Examination—Schedules for Clinical Assessment in Neuropsychiatry) to establish a diagnosis of DSM‐IV depression. They later completed the EDS with another researcher who was blind to the results of diagnostic interview. A receiver operating characteristic curve analysis was carried out to identify the optimal threshold score on the EDS and the Brief EDS to identify any depressive disorder or major depression. The performance characteristics at a range of thresholds were compared.ResultsA cut‐off score of 10/11 gave maximal discriminant validity, with 74% sensitivity, 92% specificity and 64% positive predictive value for the identification of any depression according to DSM‐IV criteria.ConclusionsThis study suggests that the EDS is both a valid and potentially useful instrument that can be used as a quick self‐completion questionnaire for screening for depression in people who have PD. Copyright © 2014 John Wiley & Sons, Ltd.
Human papillomavirus–related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor
Authors: Vainshtein Jeffrey , McHugh Jonathan B. , Spector Matthew E. , Walline Heather M. , Komarck Christine M. , Stenmark Matthew H. , Prince Mark E. , Worden Francis P. , Wolf Gregory T. , Bradford Carol R. , Chepeha Douglas B. , Carey Thomas , Eisbruch Avraham 
Published: April 2014

AbstractBackgroundAlthough typically associated with a favorable prognosis, a minority of human papillomavirus (HPV)‐related (+) oropharyngeal cancers recur after chemoradiation. We postulated that a minor HPV‐negative tumor subfraction may be responsible for recurrences of HPV+ oropharyngeal cancer.MethodsPaired untreated primary and recurrent tumor specimens were identified for 37 patients with oropharyngeal cancer who received definitive chemoradiotherapy at our institution. Concordance in HPV/p16 expression between primary and recurrent tumors was assessed.ResultsAmong 31 patients with HPV+/p16+ primary tumors, 30 (97%) retained evidence of both HPV and p16 expression at recurrence (27 HPV+/p16+; 3 HPV+/p16‐partial). One (3%) initially HPV+/p16+ patient developed an HPV‐negative/p16‐negative lung squamous cell carcinoma (SCC), representing either a discordant oropharyngeal cancer metastasis or second primary tumor.ConclusionHPV‐related oropharyngeal cancers retain HPV+/p16+ expression at recurrence. Our results fail to provide evidence that a minor HPV‐negative tumor subfraction is responsible for biologically aggressive behavior of HPV+ oropharyngeal cancer that recurs after chemoradiation. © 2014 Wiley Periodicals, Inc. Head Neck 37: 8–11, 2015
Hearing evaluation of patients with head and neck cancer: Comparison of Common Terminology Criteria for Adverse Events, Brock and Chang adverse event criteria in patients receiving cisplatin
Authors: Colevas A. Dimitrios , Lira Ruth R. , Colevas Electra A. , Lavori Philip W. , Chan Cato , Shultz David B. , Chang Kay W. 
Published: April 2014

AbstractBackgroundThe purpose of this study was to compare Common Terminology Criteria for Adverse Events (CTCAE), Brock and Chang hearing loss grading in patients with head and neck cancer receiving cis‐diamminedichloroplatinum (CDDP). Endpoints were baseline distribution of hearing loss, interobserver consistency, and sensitivity to hearing loss after CDDP treatment.MethodsFour hundred sixty single ear audiograms in 110 patients with head and neck cancer were graded. Hearing loss at baseline, interobserver agreement rates, and changes in hearing loss after CDDP were evaluated.ResultsThe Chang and Brock tools' baseline hearing loss distribution was concentrated at grade 0 (57% and 41%, respectively), whereas 47%, per the CTCAE, had grade 3 baseline hearing loss. Interobserver agreement was highest for the Brock scale (≥90%) followed by the Chang (≥89%) and CTCAE (≥75%) scales. Detection of change after CDDP was highest for Chang (48%) followed by Brock (45%) and the CTCAE (32%).ConclusionThe Brock and Chang tools may be superior to the CTCAE in patients with head and neck cancer receiving CDDP using baseline hearing loss distribution, interobserver agreement, and detection of hearing loss grade change as performance indicators. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1102–1107, 2015
Routine treatment of patients with chronic lymphocytic leukaemia by office‐based haematologists in Germany—data from the Prospective Tumour Registry Lymphatic Neoplasms
Authors: Knauf Wolfgang , Abenhardt Wolfgang , Dörfel Steffen , Meyer Dirk , Grugel Renate , Münz Michaela , Hartmann Holger , Marschner Norbert 
Published: April 2014

AbstractVarious treatment options exist for patients with chronic lymphocytic leukaemia (CLL). Clinical registries provide insight into routine treatment and identify changes in treatment over time. The Tumour Registry Lymphatic Neoplasms prospectively collects data on the treatment of patients with lymphoid B‐cell neoplasm as administered by office‐based haematologists in Germany. Data on patient and tumour characteristics, co‐morbidities, systemic treatments, and outcome parameters are recorded. Eight hundred and six patients with CLL were recruited between May 2009 and August 2013. At the start of first‐line treatment, median age was 71 years, 64% were male, and 44% had a Binet stage C disease. The most frequently used first‐line/second‐line regimens were bendamustine + rituximab (BR, 56%/55%), fludarabine + cyclophosphamide + rituximab (FCR, 22%/11%), and bendamustine (B, 5%/9%). Chlorambucil was used in only 7% (first‐line) and 6% (second‐line) of patients. Patients treated with FCR were younger and healthier than patients treated with BR. Overall, 91% of first‐line treatments were successful (40% complete response). Real‐life patient populations differ considerably from patients treated in randomized controlled trials. BR and FCR dominate the first‐line and second‐line treatments of CLL by office‐based haematologists in Germany. Future analysis will investigate progression‐free and overall survival times. © 2014 The Authors. Hematological Oncology Published by John Wiley & Sons, Ltd.
Gender moderates the effect of oxytocin on social judgments
Authors: Hoge Elizabeth A. , Anderson Eric , Lawson Elizabeth A. , Bui Eric , Fischer Laura E. , Khadge Shradha D. , Barrett Lisa Feldman , Simon Naomi M. 
Published: April 2014

ObjectiveThe neuropeptide oxytocin is implicated in social processing, and recent research has begun to explore how gender relates to the reported effects. This study examined the effects of oxytocin on social affective perception and learning.MethodsForty‐seven male and female participants made judgments of faces during two different tasks, after being randomized to either double‐blinded intranasal oxytocin or placebo. In the first task, “unseen” affective stimuli were presented in a continuous flash suppression paradigm, and participants evaluated faces paired with these stimuli on dimensions of competence, trustworthiness, and warmth. In the second task, participants learned affective associations between neutral faces and affective acts through a gossip learning procedure and later made affective ratings of the faces.ResultsIn both tasks, we found that gender moderated the effect of oxytocin, such that male participants in the oxytocin condition rated faces more negatively, compared with placebo. The opposite pattern of findings emerged for female participants: they rated faces more positively in the oxytocin condition, compared with placebo.ConclusionsThese findings contribute to a small but growing body of research demonstrating differential effects of oxytocin in men and women. Copyright © 2014 John Wiley & Sons, Ltd.
Role of α2β1 integrins in mediating cell shape on microtextured titanium surfaces
Authors: Lai Min , Hermann Christopher D. , Cheng Alice , Olivares‐Navarrete Rene , Gittens Rolando A. , Bird Meredith M. , Walker Marcus , Cai Ye , Cai Kaiyong , Sandhage Kenneth H. , Schwartz Zvi , Boyan Barbara D. 
Published: April 2014

AbstractSurface microroughness plays an important role in determining osteoblast behavior on titanium. Previous studies have shown that osteoblast differentiation on microtextured titanium substrates is dependent on alpha‐2 beta‐1 (α2β1) integrin signaling. This study used focused ion beam milling and scanning electron microscopy, combined with three‐dimensional image reconstruction, to investigate early interactions of individual cells with their substrate and the role of integrin α2β1 in determining cell shape. MG63 osteoblast‐like cells on sand blasted/acid etched (SLA) Ti surfaces after 3 days of culturing indicated decreased cell number, increased cell differentiation, and increased expression of mRNA levels for α1, α2, αV, and β1 integrin subunits compared to cells on smooth Ti (PT) surfaces. α2 or β1 silenced cells exhibited increased cell number and decreased differentiation on SLA compared to wild‐type cells. Wild‐type cells on SLA possessed an elongated morphology with reduced cell area, increased cell thickness, and more apparent contact points. Cells on PT exhibited greater spreading and were relatively flat. Silenced cells possessed a morphology and phenotype similar to wild‐type cells grown on PT. These observations indicate that surface microroughness affects cell response via α2β1 integrin signaling, resulting in a cell shape that promotes osteoblastic differentiation. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 564–573, 2015.
Quantitative regulation of bone‐mimetic, oriented collagen/apatite matrix structure depends on the degree of osteoblast alignment on oriented collagen substrates
Authors: Matsugaki Aira , Isobe Yoshihiro , Saku Taro , Nakano Takayoshi 
Published: April 2014

AbstractBone tissue has a specific anisotropic morphology derived from collagen fiber alignment and the related apatite crystal orientation as a bone quality index. However, the precise mechanism of cellular regulation of the crystallographic orientation of apatite has not been clarified. In this study, anisotropic construction of cell‐produced mineralized matrix in vitro was established by initiating organized cellular alignment and subsequent oriented bone‐like matrix (collagen/apatite) production. The oriented collagen substrates with three anisotropic levels were prepared by a hydrodynamic method. Primary osteoblasts were cultured on the fabricated substrates until mineralized matrix formation is confirmed. Osteoblast alignment was successfully regulated by the level of substrate collagen orientation, with preferential alignment along the direction of the collagen fibers. Notably, both fibrous orientation of newly synthesized collagen matrix and c‐axis of produced apatite crystals showed preferential orientation along the cell direction. Because the degree of anisotropy of the deposited apatite crystals showed dependency on the directional distribution of osteoblasts cultured on the oriented collagen substrates, the cell orientation determines the crystallographic anisotropy of produced apatite crystals. To the best of our knowledge, this is the first report demonstrating that bone tissue anisotropy, even the alignment of apatite crystals, is controllable by varying the degree of osteoblast alignment via regulating the level of substrate orientation. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 489–499, 2015.
Silicon calcium phosphate ceramic as novel biomaterial to simulate the bone regenerative properties of autologous bone
Authors: Manchón A. , Alkhraisat M. , Rueda‐Rodriguez C. , Torres J. , Prados‐Frutos J. C. , Ewald A. , Gbureck U. , Cabrejos‐Azama J. , Rodriguez‐González A. , López‐Cabarcos E. 
Published: April 2014

AbstractThis study was conducted to develop novel ceramic bone substitute that resembles the autologous bone behavior when used as graft material. Solid‐state reaction at 1100°C was performed to synthesize β‐tricalcium phosphate (β‐TCP) and biphasic calcium phosphate (BCP). The ceramics were further analyzed to characterize phase composition, microstructural properties, cytocompatability and then challenged to regenerate critical bone defects in the parietal bone of rabbits. X‐ray diffraction analysis confirmed the production of β‐TCP and indicated the synthesis of novel BCP composed of β‐TCP and silicocarnotite (calcium phosphate silicate mineral). The cytocompatibility test with human osteoblast cell line revealed enhanced cell proliferation on the BCP ceramic. The novel BCP induced the filling of about 73% of the bone defect with a newly formed bone tissue and an almost complete degradation after 12 weeks of healing. This novel ceramic resembles the autologous bone properties of complete degradation and efficient enhancement of bone formation, making it promising as bone graft material. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 479–488, 2015.
Hydroxyapatite‐titanium bulk composites for bone tissue engineering applications
Authors: Kumar Alok , Biswas Krishanu , Basu Bikramjit 
Published: April 2014

AbstractThe research work on bulk hydroxyapatite (HA)‐based composites are driven by the need to develop biomaterials with better mechanical properties without compromising its bioactivity and biocompatibility properties. Despite several years of research, the mechanical properties of the HA‐based composites still need to be enhanced to match the properties of natural cortical bone. In this regard, the scope of this review on the HA‐based bulk biomaterials is limited to the processing and the mechanical as well as biocompatibility properties for bone tissue engineering applications of a model system that is hydroxyapatite‐titanium (HA‐Ti) bulk composites. It will be discussed in this review how HA‐Ti based bulk composites can be processed to have better fracture toughness and strength without compromising biocompatibility. The advantages of the functionally gradient materials to integrate the mechanical and biocompatibility properties is a promising approach in hard tissue engineering and has been emphasized here in reference to the limited literature reports. On the biomaterials fabrication aspect, the recent results are discussed to demonstrate that advanced manufacturing techniques, like spark plasma sintering can be adopted as a processing route to restrict the sintering reactions, while enhancing the mechanical properties. Various toughening mechanisms related to careful tailoring of microstructure are discussed. The in vitro cytocompatibilty, cell fate processes as well as in vivo biocompatibility results are also reviewed and the use of flow cytometry to quantify in vitro cell fate processes is being emphasized. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 791–806, 2015.