bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemically Treated Breast Cancer Patients and Controls: An Evaluation of the Presence of Noncredible Performance
Authors: Wefel Jeffrey S. , Kornet Rozemarijn L. , Schagen Sanne B. 
Published: March 2014

AbstractThis study sought to define the frequency of noncredible performance in breast cancer patients before, during and after completion of systemic treatment, as well as predictors of noncredible performance. We examined six datasets investigating the cognitive effects of chemotherapy and/or endocrine therapy. Embedded performance validity test (PVT) measures were identified and used to evaluate the datasets. One dataset included a standalone PVT. Possible noncredible performance was operationally defined as performance below criterion on three or more PVT indices. This was undertaken as cancer patients have been observed clinically to fail PVTs both in the context of external gain and independent of such motivators. A total of 534 breast cancer patients and 214 healthy controls were included in the analysis. Percentages of patients performing below cutoff on one or more PVT varied from 0% to 21.2%. Only 1 patient met the criterion of noncredible performance. Calculation of post-test probabilities indicated a more than 90% chance to detect noncredible performance. There is no evidence to suggest noncredible performance in breast cancer patients and healthy controls who choose to participate in research studies examining cognitive function. Thus, the observational data showing that non-central nervous system (CNS) cancer and therapies not targeting the CNS can have untoward effects on cognitive function are unlikely to be due to noncredible performance. (JINS, 2014, 19, 1–13)
Spiritual AIM and the work of the chaplain: A model for assessing spiritual needs and outcomes in relationship
Authors: Shields Michele , Kestenbaum Allison , Dunn Laura B. 
Published: March 2014

AbstractObjective:Distinguishing the unique contributions and roles of chaplains as members of healthcare teams requires the fundamental step of articulating and critically evaluating conceptual models that guide practice. However, there is a paucity of well-described spiritual assessment models. Even fewer of the extant models prescribe interventions and describe desired outcomes corresponding to spiritual assessments.Method:This article describes the development, theoretical underpinnings, and key components of one model, called the Spiritual Assessment and Intervention Model (Spiritual AIM). Three cases are presented that illustrate Spiritual AIM in practice. Spiritual AIM was developed over the past 20 years to address the limitations of existing models. The model evolved based in part on observing how different people respond to a health crisis and what kinds of spiritual needs appear to emerge most prominently during a health crisis.Results:Spiritual AIM provides a conceptual framework for the chaplain to diagnose an individual's primary unmet spiritual need, devise and implement a plan for addressing this need through embodiment/relationship, and articulate and evaluate the desired and actual outcome of the intervention. Spiritual AIM's multidisciplinary theory is consistent with the goals of professional chaplaincy training and practice, which emphasize the integration of theology, recognition of interpersonal dynamics, cultural humility and competence, ethics, and theories of human development.Significance of Results:Further conceptual and empirical work is needed to systematically refine, evaluate, and disseminate well-articulated spiritual assessment models such as Spiritual AIM. This foundational work is vital to advancing chaplaincy as a theoretically grounded and empirically rigorous healthcare profession.
Garbage in, garbage out? Some micro sources of macro errors
Authors: SUNSTEIN CASS R. , HASTIE REID 
Published: March 2014

AbstractMany institutions, large or small, make their decisions through some process of deliberation. Nonetheless, deliberating institutions often fail, in the sense that they make judgments that are false or that fail to take advantage of the information that their members have. Micro mistakes can lead to macro blunders or even catastrophes. There are four such failures; all of them have implication for large-scale institutions as well as small ones. (1) Sometimes the predeliberation errors of an institution's members are amplified, not merely propagated, as a result of deliberation. (2) Institutions fall victim to cascade effects, as the initial speakers or actors are followed by their successors, who do not disclose what they know. Non-disclosure, on the part of those successors, may be a product of either informational or reputational cascades. (3) As a result of group polarization, deliberating institutions sometimes end up in a more extreme position in line with their predeliberation tendencies. Sometimes group polarization leads in desirable directions, but there is no assurance to this effect. (4) In deliberating institutions, shared information often dominates or crowds out unshared information, ensuring that institutions do not learn what their members know. Informational signals and reputational pressure help to explain all four errors. The results can be harmful to numerous institutions, including large ones, and to societies as a whole. Markets are able to correct some of these problems, but cascade effects occur there as well.
Theoretical Prediction of Electronic Structure and Carrier Mobility in Single-walled MoS2 Nanotubes
Authors: Xiao Jin , Long Mengqiu , Li Xinmei , Xu Hui , Huang Han , Gao Yongli 
Published: March 2014

AbstractWe have investigated the electronic structure and carrier mobility of armchair and zigzag single-walled MoS2nanotubes using density functional theory combined with Boltzmann transport method with relaxation time approximation. It is shown that armchair nanotubes are indirect bandgap semiconductors, while zigzag nanotubes are direct ones. The band gaps of single-walled MoS2nanotubes are along with the augment of their diameters. For armchair nanotubes (5 ≤Na≤ 14), the hole mobility raise from 98.62 ~ 740.93 cm2V−1s−1at room temperature, which is about six times of the electron mobility. For zigzag nanotubes (9 ≤Na≤ 15), the hole mobility is 56.61 ~ 91.32 cm2V−1s−1at room temperature, which is about half of the electron mobility.
Different Impacts of α- and β-Blockers in Neurogenic Hypertension Produced by Brainstem Lesions in Rat
Authors: Lu Wen-Hsien , Hsieh Kai-Sheng , Lu Pei-Jung , Wu Yi-Shan , Ho Wen-Yu , Cheng Pei-Wen , Lai Chi-Cheng , Hsiao Michael , Tseng Ching-Jiunn 
Published: March 2014

Abstract

Background:
Bilateral lesions of nucleus tractus solitarii in rat result in acute hypertension, pulmonary edema, and death within hours. The hypertension results from excessive catecholamine release. Catecholamine can activate connexin43 to regulate cell death. There is no study investigating the cardiopulmonary impacts of different adrenergic blockers and apoptosis mechanism in rat model.

Methods:
The authors microinjected 6-hydroxydopamine into nucleus tractus solitarii of the rat (n = 8 per group) and evaluated the cardiopulmonary changes after treatment with different concentrations of α1-blockers, α2-blockers, β-blockers, and α-agonists.

Results:
In the rat model, the authors found that prazosin (0.15 mg/kg) treatment could preserve cardiac output and reverse neutrophil infiltrations in lungs and lead to prevent pulmonary hemorrhagic edema. The time-dependent increases in connexin43 and terminal deoxynucleotidyl transferase dUTP nick end labeling–positive cells induced by 6-hydroxydopamine lesions were decreased after prazosin treatment (terminal deoxynucleotidyl transferase dUTP nick end labeling–positive cells at 6 h: 64.01 ± 2.41% vs. 24.47 ± 3.10%; mean ± SD, P < 0.001, in heart, and 80.83 ± 2.52% vs. 2.60 ± 1.03%, P < 0.001, in lung). However, propranolol caused further compromise of the already impaired cardiac output with consequence of rapid death. Phenylephrine enhanced the phenotype in the link between connexin43 expressions and terminal deoxynucleotidyl transferase dUTP nick end labeling–positive cells but not yohimbine. Connexin43 expressions and terminal deoxynucleotidyl transferase dUTP nick end labeling–positive cells were more decreased with prazosin (0.15 and 0.3 mg/kg) than that with prazosin (0.05 mg/kg) treatment.

Conclusions:
α1-Receptors are the keystones of the phenotype. In some brainstem encephalitis and brain injury with nucleus tractus solitarii involvement, early α1-receptor blockade treatment may prevent acute death from tissue apoptosis. α-Blockers can also decrease cerebral perfusion pressure, and further studies are needed in translation to brain injury with increased intracranial pressure.
Understanding the placebo effect in clinical trials for postural tachycardia syndrome
Authors: Nwazue Victor C , Arnold Amy C , Raj Vidya , Black Bonnie K , Biaggioni Italo , Paranjape Sachin Y , Orozco Carlos , Dupont William D , Robertson David , Raj Satish R 
Published: March 2014

SummaryPostural tachycardia syndrome (POTS) is characterized by excessive increases in heart rate (HR) upon standing. Previous studies have shown that standing HR decreases over time in POTS patients given placebo. We hypothesized that this reduction is due to cardiovascular physiological alteration, as opposed to psychological benefit from perceived therapy. To prospectively test this hypothesis, we examined the effects of an open‐label ‘no treatment’ intervention (NoRx) compared with a patient‐blinded placebo on standing HR in POTS patients. Twenty‐one POTS patients participated in a randomized cross‐over trial with oral placebo versus NoRx administered at 0900 h. Seated blood pressure (BP) and HR were measured at baseline and every hour for 4 h. Similarly, BP and HR were measured while patients stood for 10 min at these time points. Standing HR decreased significantly over time with both NoRx (112 ± 13 and 103 ± 16 b.p.m. at baseline and 4 h, respectively) and placebo (112 ± 14 and 102 ± 16 b.p.m. at baseline and 4 h, respectively; Ptime < 0.001), but this effect was not different between interventions (Pdrug = 0.771). Postural tachycardia syndrome patients have exaggerated orthostatic tachycardia in the morning that decreases over time with either placebo or NoRx interventions, suggesting this phenomenon is due to cardiovascular physiological variation. These data highlight the need for a placebo arm in haemodynamic clinical trials in POTS and may have important implications for the diagnosis of these patients.
GABAA receptors are involved in the analgesic effects of morphine microinjected into the central nucleus of the amygdala
Authors: Rashvand Mina , Khajavai Ali , Parviz Mohsen , Hasanein Parisa , Keshavarz Mansoor 
Published: March 2014

SummaryThe central nucleus of the amygdala (CeA) has an important role in pain perception and analgesia. Opioid and GABAA receptors, which are both involved in pain modulation, are found in high concentration in the CeA. The present study was designed to examine the interaction of opioidergic and GABAergic systems in the CeA during modulation of acute thermal pain. In the present study, different doses of morphine (25, 50 and 100 μg/rat), either alone or after 5 min pretreatment with the selective GABAA receptor agonist muscimol (60 ng/rat) or the selective GABAA receptor antagonist bicuculline (50 ng/rat), were injected bilaterally into the CeA of each rat. Tail‐flick latencies (TFL) were measured every 5 min for 60 min. The results revealed that microinjection of morphine into the CeA significantly increased TFL in a dose‐dependent manner. Microinjection of bicuculline or muscimol in combination with morphine into the CeA increased and decreased TFL, respectively. It seems that morphine in the CeA facilitates the function of descending inhibitory systems by interacting with the activity of local GABAA receptors.
Maternal fructose intake during pregnancy modulates hepatic and hypothalamic AMP‐activated protein kinase signalling in a sex‐specific manner in offspring
Authors: Mukai Yuuka , Ozaki Haruka , Serita Yuko , Sato Shin 
Published: March 2014

SummaryDietary fructose ingestion during gestation affects carbohydrate metabolism in the offspring. In the present study, we investigated the effects of excess fructose intake during pregnancy on hepatic and hypothalamic AMP‐activated kinase (AMPK) expression and phosphorylation, as well as hepatic glucose‐6‐phosphatase (G6Pase) activity in offspring. Pregnant Wistar rats received normal chow and 100 g/L fructose solution or normal water during gestation ad libitum. On gestational Day 21, some dams were killed and plasma samples and fetuses were collected. The remaining dams received normal water after spontaneous delivery during lactation. Pups were killed on postnatal Day 22 and the plasma, liver and hypothalamus were collected and analysed. Plasma glucose and insulin levels increased in female but not male offspring in the fructose group. Although the mRNA and total protein levels of AMPKα were unchanged, levels of phosphorylated AMPKα protein in the fructose group of female offspring were significantly lower in the liver and 4.6‐fold higher in the hypothalamus. The hepatic protein level of sirtuin 1, which is involved in AMPK phosphorylation and activation, was significantly reduced in the fructose group of female offspring. The activity of G6Pase, which plays a role in gluconeogenesis, was significantly enhanced in the liver of female offspring from fructose‐fed dams. These changes were not observed in male offspring. In conclusion, we found that excessively high fructose intake during pregnancy may modulate the hepatic and hypothalamic AMPK signalling pathways in female offspring after birth.
MrpacC regulates sporulation, insect cuticle penetration and immune evasion in Metarhizium robertsii
Authors: Huang Wei , Shang Yanfang , Chen Peilin , Gao Qiang , Wang Chengshu 
Published: March 2014

SummarypH‐responsive transcription factor of the PacC/Rim101 family governs adaptation to environment, development and virulence in many fungal pathogens. In this study, we report the functions of a PacC homologue, MrpacC, in an insect pathogenic fungus Metarhizium robertsii. The gene was highly transcribed in the fungus in alkaline conditions, and deletion of MrpacC impaired fungal responses to ambient pH and salt/metal challenges but not osmotic stress. We found that MrpacC is required for fungal full virulence by contributing to penetration of insect cuticles, mycosis of insect cadavers and evasion of host immunity. In MrpacC deletion strains, the chitinase but not protease activity was reduced, which was consistent with the downregulation of groups A and C chitinase genes. Further, the glucosyltransferase genes involved in cell wall remodelling and protein glycosylation were upregulated in ΔMrpacC. MrpacC transcriptional control of chitinase and glucosyltransferase genes was verified both by the presence of PacC consensus binding motif in gene promoter regions and the promoter DNA‐binding assays. The results of this study not only advances the understanding of PacC function in fungal development and virulence, but will also facilitate future studies on the mechanism(s) behind the selective control of target genes by PacC.
Everybody Knows This is Nowhere: The Kiev Park of Memory and Post‐Soviet Urbanism in Context
Authors: Hatherley Owen 
Published: March 2014

AbstractThe reappraisal of the post‐Soviet landscape is in danger of overlooking two of its most important elements: firstly, the mass modernist housing that was more extensive here than probably anywhere else; and secondly, the post‐1989 capitalist context of property speculation, office development and decay. These routinely missed landscapes constitute the very things travelled through on the way to utopian, if ruined, monuments, such as those documented in Frédéric Chaubin's CCCP — Cosmic Communist Constructions Photographed. When visited, the surroundings of these structures turn out to be at least as interesting as the photogenic modernist monument itself. This essay is an account of a visit to one of the most architecturally contemporary of these structures — the Park of Memory crematoria in the Ukrainian capital, Kiev, designed by Abraham Miletsky in 1974. In Chaubin's photographs, the curling concrete volumes of the Park's central crematoria are flamboyant, fantastical and self‐referential, the very ‘iconic’ architecture that many post‐Soviet capitals would like to have in order to attract tourists. There is a lot more going on in the surrounding city than what is typically recorded in its visual representations, however, as discussed in this essay. Such monuments are not mute, and cannot be severed from their surroundings.
Translating Space: the Politics of Ruins, the Remote and Peripheral Places
Authors: Martin Daryl 
Published: March 2014

AbstractThis essay surveys recent artistic, literary and philosophical treatments of landscape that use metaphors of ruination, remoteness and the periphery. The discussion primarily focuses on Patrick Keiller's recent works, particularly his filmRobinson in Ruins, the account of remote spaces in Paul Farley and Michael Symmons Roberts' bookEdgelands, and a collection of essays by Stavros Stavrides on peripheral urban spaces,Towards the City of Thresholds. These treatments of landscape offer an attention to the social significance of spaces overlooked within wider cultural representations of place. It is suggested that all three illustrate the argument that mundane spaces can be read and translated into politicized landscapes offering alternative readings of past events, as well as potential directions for future forms of sociality.
Type 2 diabetes mellitus‐related genetic polymorphisms in microRNAs and microRNA target sites (MicroRNAs中与2型糖尿病相关的基因多态性及microRNA靶位)
Authors: Gong Weijing , Xiao Di , Ming Guangfeng , Yin Jiye , Zhou Honghao , Liu Zhaoqian 
Published: March 2014

AbstractMicroRNAs (miRNAs) are important endogenous regulators in eukaryotic gene expression and a broad range of biological processes. MiRNA‐related genetic variations have been proved to be associated with human diseases, such as type 2 diabetes mellitus (T2DM). Polymorphisms in miRNA genes (primary miRNAs, precursor miRNAs, mature miRNAs, and miRNA regulatory regions) may be involved in the development of T2DM by changing the expression and structure of miRNAs and target gene expression. Genetic polymorphisms of the 3′‐untranslated region (UTR) in miRNA target genes may destroy putative miRNA binding sites or create new miRNA binding sites, which affects the binding of UTRs with miRNAs, finally resulting in susceptibility to and development of T2DM. Therefore, focusing on studies into genetic polymorphisms in miRNAs or miRNA binding sites will help our understanding of the pathophysiology of T2DM development and lead to better health management. Herein, we review the association of genetic polymorphisms in miRNA and miRNA targets genes with T2DM development.
Nitrospina‐like bacteria are the main drivers of nitrite oxidation in the seasonal upwelling area of the Eastern South Pacific (Central Chile ∼36°S)
Authors: Levipan Héctor A. , Molina Verónica , Fernandez Camila 
Published: March 2014

SummaryAerobic nitrite oxidation in marine environments plays a key role in the nitrification process. Marine bacteria involved in this nitrate‐producing process have however been seldom studied compared with the ammonia‐oxidizing community. Here, we report for the first time the community structure of aerobic nitrite‐oxidizing bacteria (NOB) in the seasonal upwelling and oxygen‐deficient area off Central Chile. Analysis of 16S rRNA by tag pyrosequencing was combined with specific quantitative polymerase chain reaction (qPCR) and reverse transcription qPCR in summer and wintertime. Nitrospina‐like bacteria were the only known NOB detected by means of pyrosequencing between 30 and 80 m depth, accounting for up to 5% of total bacteria. This guild was represented by 11 and 7 operational taxonomic units (97% cut‐off) in winter and summertime respectively. Nitrospina‐like bacteria were phylogenetically related to sequences retrieved from coastal upwelling, oxygen minimum zones and deep‐sea environments. This group was also detected by qPCR with abundances that increased with depth throughout the water column. Importantly, Nitrospina from surface layers showed low abundances but high 16S rRNA : rDNA ratios and mainly in summertime. Overall, our results highlight the seasonal variability between the structure and physiological state of this community and suggest a significant role of Nitrospina in the nitrogen cycle of seasonal upwelling areas.
Alcohol‐Preferring Rats Show Decreased Corticotropin‐Releasing Hormone‐2 Receptor Expression and Differences in HPA Activation Compared to Alcohol‐Nonpreferring Rats
Authors: Yong Weidong , Spence John Paul , Eskay Robert , Fitz Stephanie D. , Damadzic Ruslan , Lai Dongbing , Foroud Tatiana , Carr Lucinda G. , Shekhar Anantha , Chester Julia A. , Heilig Markus , Liang Tiebing 
Published: March 2014

BackgroundCorticotropin‐releasing hormone (CRH) and urocortins (UCNs) bind to corticotropin‐releasing hormone type 2 receptor (CRF2 receptor), a Gs protein‐coupled receptor that plays an important role in modulation of anxiety and stress responses. The Crhr2 gene maps to a quantitative trait locus (QTL) for alcohol preference on chromosome 4 previously identified in inbred alcohol‐preferring (iP) and‐nonpreferring (iNP) F2 rats.MethodsReal‐time polymerase chain reaction was utilized to screen for differences in Crhr2 mRNA expression in the central nervous system (CNS) of male iP and iNP rats. DNA sequence analysis was then performed to screen for polymorphism in Crhr2 in order to identify genetic variation, and luciferase reporter assays were then applied to test their functional significance. Next, binding assays were used to determine whether this polymorphism affected CRF2 receptor binding affinity as well as CRF2 receptor density in the CNS. Finally, social interaction and corticosterone levels were measured in the P and NP rats before and after 30‐minute restraint stress.ResultsCrhr2 mRNA expression studies found lower levels of Crhr2 mRNA in iP rats compared to iNP rats. In addition, DNA sequencing identified polymorphisms in the promoter region, coding region, and 3′‐untranslated region between the iP and iNP rats. A 7 bp insertion in the Crhr2 promoter of iP rats altered expression in vitro as measured by reporter assays, and we found that CRF2 receptor density was lower in the amygdala of iP as compared to iNP rats. Male P rats displayed decreased social interaction and significantly higher corticosterone levels directly following 30‐minute restraint when compared to male NP rats.ConclusionsThis study identified Crhr2 as a candidate gene of interest underlying the chromosome 4 QTL for alcohol consumption that was previously identified in the P and NP model. Crhr2 promoter polymorphism is associated with reduced mRNA expression in certain brain regions, particularly the amygdala, and lowered the density of CRF2 receptor in the amygdala of iP compared to iNP rats. Together, these differences between the animals may contribute to the drinking disparity as well as the anxiety differences of the P and NP rats.