bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposomal Drug Delivery: Progress, Clinical Outlook, and Ongoing Challenges
Authors: Tiwari Chanchal , Tomer Jigyasa , Kumar Dharmendra 
Published: July 2024

:
The liposomal drug delivery system is considered an advanced drug delivery technology
for formulating lipid core nano-structured particles using lipids from natural and synthetic sources.
Liposomes play a wide role in improving drugs with less solubility and greater toxicity profile. Liposomes
have numerous advantages, such as enhanced drug loading, good biocompatibility, prolonged
drug release profile, and better pharmacokinetic properties. Numerous attempts have been
made in this field in the last few years, and lots of liposomal formulations are currently being sold
all over the world, and few are under clinical study. Liposomal delivery technology improves the
challenges of encapsulating poor soluble drugs and maintains the stability of the formulation, along
with improving the challenges of in-vivo outcomes of liposomes. The present review discussed the
brief outline of the liposome drug delivery system, the innovations in the clinical application, and
the significant challenges in liposomal technology.
In silico Analysis of Berberine as a Potential Therapeutic Approach for Various Signalling Pathways Linked to Androgenetic Alopecia
Authors: Majhi Sagarika , Vinayak Chaitanya , Chauhan Iti , Verma Madhu , Sharma Sourabh 
Published: July 2024

Background:
Alopecia is defined by a loss of hair density and is often considered a
symptom of multiple illnesses, such as infection and inflammation.

Objective:
The molecular mechanisms underlying the hair-promoting effects include inhibition of
5α-reductase activity, reducing the binding affinity of Dihydrotestosterone (DHT) to androgen receptors,
and decreasing/down-regulating TGF-β2 activity, which have a suggestive role in androgenetic
alopecia. Finasteride and minoxidil are the approved non-surgical treatment alternatives
for hair loss, but they cause side effects in patients. Therefore, bioactive phytoconstituents with
multiple targets can be used to find novel, secure, and efficacious hair-promoting medicinal products.

Methods:
This study has carried out the in silico evaluation of berberine using various software.
To find possible interactions between the 5α-reductase enzyme and Transforming Growth Factor--
beta 2 (TGF-β2), a critical protein involved in the human hair development cycle, computer-aided
drug discovery was employed.

Results:
According to in silico studies, berberine has been found to bind well to the 4K7a and
6M2N binding sites. The drug has been found to adhere to Lipinski's rule of five, and its pharmacokinetic
characteristics were noteworthy. Drug-likeness and Absorption, Distribution,
Metabolism, Excretion, and Toxicity (ADMET) properties showed appreciable results. Furthermore,
berberine showed docking scores of -8.4 (5α-reductase) and -7.1 (TGF-β2), which were significantly
better than minoxidil (-4.8, -3.2). In general, the drug exhibited improved binding interactions,
and the possible toxicity investigations provided very little basis for risk prediction.

Conclusion:
The current protocol has offered experimental support for berberine's possible therapeutic
use in reducing male pattern baldness. Therefore, it can be a possible target for the therapy
of androgenetic alopecia through the regulation of TGF-β2 and 5α-reductase activity.
Targeting COVID-19 and Human Resources for Health News Information Extraction: Algorithm Development and Validation
Authors: Ravaut Mathieu , Zhao Ruochen , Phung Duy , Qin Vicky Mengqi , Milovanovic Dusan , Pienkowska Anita , Bojic Iva , Car Josip , Joty Shafiq 
Published: July 2024

Background
Global pandemics like COVID-19 put a high amount of strain on health care systems and health workers worldwide. These crises generate a vast amount of news information published online across the globe. This extensive corpus of articles has the potential to provide valuable insights into the nature of ongoing events and guide interventions and policies. However, the sheer volume of information is beyond the capacity of human experts to process and analyze effectively.

Objective
The aim of this study was to explore how natural language processing (NLP) can be leveraged to build a system that allows for quick analysis of a high volume of news articles. Along with this, the objective was to create a workflow comprising human-computer symbiosis to derive valuable insights to support health workforce strategic policy dialogue, advocacy, and decision-making.

Methods
We conducted a review of open-source news coverage from January 2020 to June 2022 on COVID-19 and its impacts on the health workforce from the World Health Organization (WHO) Epidemic Intelligence from Open Sources (EIOS) by synergizing NLP models, including classification and extractive summarization, and human-generated analyses. Our DeepCovid system was trained on 2.8 million news articles in English from more than 3000 internet sources across hundreds of jurisdictions.

Results
Rules-based classification with hand-designed rules narrowed the data set to 8508 articles with high relevancy confirmed in the human-led evaluation. DeepCovid’s automated information targeting component reached a very strong binary classification performance of 98.98 for the area under the receiver operating characteristic curve (ROC-AUC) and 47.21 for the area under the precision recall curve (PR-AUC). Its information extraction component attained good performance in automatic extractive summarization with a mean Recall-Oriented Understudy for Gisting Evaluation (ROUGE) score of 47.76. DeepCovid’s final summaries were used by human experts to write reports on the COVID-19 pandemic.

Conclusions
It is feasible to synergize high-performing NLP models and human-generated analyses to benefit open-source health workforce intelligence. The DeepCovid approach can contribute to an agile and timely global view, providing complementary information to scientific literature.
Sustained 3-Year Improvement of Glucose Control With Hybrid Closed Loop in Children With Type 1 Diabetes While Going Through Puberty
Authors: Bismuth Élise , Tubiana-Rufi Nadia , Rynders Corey A. , Dalla-Vale Fabienne , Bonnemaison Elisabeth , Coutant Régis , Farret Anne , Poidvin Amélie , Bouhours-Nouet Natacha , Storey Caroline , Donzeau Aurélie , DeBoer Mark D. , Breton Marc D. , Villard Orianne , Renard Éric 
Published: July 2024

OBJECTIVE
To evaluate the impact of prolonged hybrid closed loop (HCL) use in children with type 1 diabetes (T1D) on glucose control and BMI throughout pubertal progression.

RESEARCH DESIGN AND METHODS
We used a prospective multicenter extension study following the Free-Life Kid AP (FLKAP) HCL trial. The 9-month previously reported FLKAP trial included 119 prepubertal children (aged 6–12 years). During the extension study, participants could continue to use HCL for 30 months (M9 to M39). HbA1c values were collected every 3 months up to M39, while continuous glucose monitoring metrics, BMI z scores, and Tanner stages were collected up to M24. Noninferiority tests were performed to assess parameter sustainability over time.

RESULTS
One hundred seventeen children completed the extension study, with mean age 10.1 years (minimum to maximum, 6.8–14.0) at the beginning. Improvement of HbA1c obtained in the FLKAP trial was significantly sustained during extension (median [interquartile range], M9 7.0% [6.8–7.4], and M39 7.0% [6.6–7.4], P &lt; 0.0001 for noninferiority test) and did not differ between children who entered puberty at M24 (Tanner stage ≥2; 54% of the patients) and patients who remained prepubertal. BMI z score also remained stable (M9 0.41 [−0.29 to 1.13] and M24 0.48 [−0.11 to 1.13], P &lt; 0.0001, for noninferiority test). No severe hypoglycemia and one ketoacidosis episode not related to the HCL system occurred.

CONCLUSIONS
Prolonged use of HCL can safely and effectively mitigate impairment of glucose control usually associated with pubertal progression without impact on BMI in children with T1D.
اشكالية التكييف القانوني للمخدرات الرقمية بين مقاربتي المخدرات التقليدية والاحتيال الالكتروني
Authors: Abdulkareem Fahil A. 
Published: July 2024

يتناول هذا البحث الاشكالية في ايجاد الية قانونية لتكييف المخدرات الرقمية، وبالتالي بيان المسؤولية الجنائية وفق المنظومة الجنائية العراقية الحالية، هذا من جانب، ومن جانب اخر، حاولنا حث المشرعين العراقي الاتحادي والكردستاني الاقليمي (اقليم كردستان العراق) على القيام بمزامنة تداعيات الجرائم الالكترونية المستحدثة واستشراف العواقب المستقبلية المترتبة من جراء مثل هذه الجرائم، انطلاقا من مبدأ حماية أمن واستقرار وسلامة المجتمع عن طريق سن قوانين عصرية لمواجهة الجرائم الالكترونية، وعدم افلات مرتكبيها من العقاب. لذا، من أجل الاحاطة بموضوع البحث، قمنا بتقسيمه الى مبحثين؛ في المبحث الاول، قمنا بدراسة ماهية المخدرات الرقمية، من خلال تعريف والية عمل هذه المخدرات، بالإضافة الى دراسة التحديات العلمية والقانونية لمواجهة المخدرات الرقمية، بينما في المبحث الثاني قمنا بدراسة الالية القانونية لتكييف المخدرات الرقمية، من خلال مقاربتين، في اولهما حاولنا تكييف المخدرات الرقمية كمخدرات تقليدية، بينما في المقاربة الثانية حاولنا تكييف هذه المخدرات كجريمة احتيال الالكتروني. وفي هذه الخطوة الاستباقية، وبالاستناد الى مبادئ العدالة التنبؤية، حاولنا وضع استراتيجية جنائية مساعدة من اجل الوصول تشريعيا لحل اشكالية تكييف المخدرات الرقمية من خلال هاتين المقاربتين.
Transparency, integrity and anti-corruption
Authors:   Faculty of Law – Jadara Uni. - Jordan, Alamosh Maher 
Published: July 2024

البحث يركز على موضوعات الشفافية، النزاهة، ومكافحة الفساد في البيئات الحكومية. يتناول البحث أهمية هذه القضايا في تعزيز الثقة بين المواطنين والحكومات، وضرورة تحقيق المساءلة والشفافية في الإدارة العامة. وتم تحليل التشريعات والسياسات المختلفة التي تعنى بهذه المسائل، وتمثلت توصيات البحث في: -	ضرورة تعزيز ثقافة الشفافية والنزاهة في المؤسسات الحكومية من خلال تطبيق سياسات تشجيعية وتوفير الدورات التدريبية. -	تحسين التشريعات واللوائح لتعزيز مكافحة الفساد وتحقيق النزاهة في إدارة الشؤون العامة. -	تشجيع المشاركة المجتمعية في رصد ومكافحة الفساد من خلال توفير وسائل للإبلاغ عن الممارسات غير الأخلاقية. -	توفير نظم تقنية لتعزيز الشفافية في الإجراءات الحكومية وتوفير الوثائق والمعلومات بشكل شفاف وسهل الوصول. -	تحسين العقوبات والتدابير التأديبية لمن يثبت تورطهم في الفساد وتشجيع القضاء على المساءلة. -	يجب أن يكون تحقيق الشفافية والنزاهة ومكافحة الفساد أولويات للدولة والمجتمع لضمان استدامة التنمية وتحقيق العدالة الاجتماعية والاقتصادية.
PENGARUH KOMPETENSI PUSTAKAWAN TERHADAP KUALITAS LAYANAN DI DINAS PERPUSTAKAAN DAN ARSIP KOTA BIMA
Authors: Syahruramadhan Syahruramadhan , Haruddin  
Published: July 2024

Penelitian ini membahas tentang Pengaruh Kompetensi Pustakawan terhadap Kualitas Layanan di Dinas Perpustakaan dan Arsip Kota Bima dengan tujuan untuk: 1) Mengetahui Bagaimana Kompetensi Pustakawan di Dinas Perpustakaan dan Arsip Kota Bima, 2) Untuk mengetahui Bagaimana Kualitas Layanan di Dinas Perpustakaan dan Arsip Kota Bima, 3) Untuk mengetahui Sejauh Mana Pengaruh Kompetensi Pustakawan Terhadap Kualitas Layanan di Dinas Perpustakaan dan Arsip Kota Bima.
Jenis penelitian ini adalah penelitian kuantitatif, yang berlokasi di Dinas Perpustakaan dan Arsip Kota Bima dengan menggunakan pendekatan manajerial. Pendekatan manajerial adalah sebuah pendekatan yang bersifat sistematis dan teratur dalam menyusun dan melibatkan unsur-unsur yang terpadu untuk melihat pengaruh kompetensi pustakawan terhadap kualitas layanan. Penelitian ini terdiri atas satu variabel independen dan satu variabel, populasi dalam penelitian ini adalah seluruh masyarakat Kota Bima yang berkunjung ke perpustakaan selama penelitian berlangsung. Teknik penarikan sampel yang dipilih adalah Accidental sampling yakni teknik yang dilakukan dengan cara menentukan siapa saja yang kebetulan ditemui oleh peneliti dan dipandang tepat untuk mewakili sebuah populasi.
Hasil penelitian yang didapat dari pengumpulan data melalui observasi, angket dan dokumentasi yang diolah menggunakan SPSS, diketahui bahwa Kompetensi Pustakawan memiliki pengaruh yang cukup signifikan terhadap Kualitas Layanan di Dinas Perpustakaan dan Arsip Kota Bima. Terlihat dari hasil uji regresi linear sederhana yaitu membandingkan nilai signifikansi dengan nilai probabilitas dan membandingkan nilai thitung dan ttabel. Berdasarkan nilai signifikansi: diketahui nilai signifikansi sebesar 0,000 < 0,05 sehingga dapat disimpulkan bahwa variabel X berpengaruh terhadap variabel Y. Berdasarkan nilai t: diketahui nilai t hitung sebesar 3,417 > t tabel sebesar 2,048 sehingga dapat disimpulkan bahwa variabel X berpengaruh terhadap variabel Y, dengan nilai persamaan regresi 0,322. Koefisien regresi tersebut bernilai positif.
Implikasi dari penelitian ini adalah sebaiknya pelatihan dan pengembangan kepustakawanan lebih ditingkatkan lagi dari lembaga-lembaga yang membawahi setiap organisasi perpustakaan yang ada, sehingga kualitas atau kompetensi seorang pustakawan lebih di apresiasi tinggi. Selain itu diharapkan juga bagi pustakawan untuk selalu memegang teguh kode etik profesi sehingga dapat menjaga harkat dan martabat profesi pustakawan.
Representaciones sociales sobre las altas capacidades entre estudiantes en formación docente
Authors: Baquero Gomide Fabiola , Guillén Martín Verónica Marina , Gallego Álvarez Teresa , Llinares-Insa Lucía Inmaculada , Casino García Ana Maria , Ibáñez García Alba 
Published: July 2024

Este estudio examina las concepciones y creencias arraigadas en la escuela acerca de las altas capacidades, que pueden obstaculizar el adecuado desarrollo educativo y la atención a la diversidad de este alumnado, a través del análisis de las representaciones sociales presentes entre estudiantes universitarios en formación docente. La investigación tiene un enfoque mixto, utilizando para su análisis la teoría de representaciones sociales por medio de un análisis prototípico de palabras, con la participación de 274 individuos. Los resultados revelan que la palabra “inteligente” prevalece en todas las representaciones sociales, mientras que los elementos periféricos varían y se relacionan más con aspectos socioemocionales. La formación académica se destaca como un elemento importante que desestabiliza el núcleo central de la representación, ofreciendo una visión más holística del concepto. En la percepción colectiva del grupo investigado, se identifican varios mitos, estereotipos y falsas creencias. Entre ellos, destaca la creencia en la idea de que las altas capacidades son innatas. Además, persiste el estereotipo de que este alumnado siempre sobresale en rendimiento, y la presencia de dificultades en su adaptación personal y social.

Social representations of giftedness among university students in preservice teacher
Abstract
This study examines the conceptions and beliefs entrenched in schools regarding giftedness, which hinder the proper educational development and attention to the diversity of these students. It focuses on the social representations present among university students in preservice teacher. The research adopts a mixed-method approach, utilizing social representations theory through prototypical word analysis, with the participation of 274 individuals. The results reveal that the word “intelligent” prevails in all social representations, while peripheral elements vary and are more related to socioemotional aspects. Academic training stands out as an important element that destabilizes the central core of the representation, offering a more holistic view of the concept. In the collective perception of the investigated group, several myths, stereotypes, and false beliefs are identified. Among them, the belief in the idea that giftedness is innate stands out. Additionally, the stereotype persists that these students always excel in performance and face difficulties in their personal and social adaptation.
Immunohistochemical characterization of inflammatory infiltrates in unstable vitiligo
Authors: Singh Priyanka , Mishra Pallavi , Yadav Amit Kumar , Khunger Niti 
Published: July 2024

Objectives:
Disease instability in vitiligo is a prominent step during the development or extension of disease. The presence of marked inflammatory infiltrate may be considered a diagnostic clue for disease instability. However, there is a paucity of literature regarding this. Therefore, the present study was carried out to characterize the nature of inflammatory infiltration in cases of unstable vitiligo.

Materials and Methods:
Thirty patients of unstable vitiligo diagnosed clinically were enrolled and two biopsies: Lesional and perilesional obtained. Histopathological examination with respect to five parameters, i.e., spongiosis, epidermal lymphocytes, basal cell vacuolation, dermal lymphocytes, and melanophages was done including histological scoring. Immunohistochemical characterization was done for T lymphocytes, Langerhans cells (LCs), macrophages, and B cells by studying their number and distribution.

Statistical analysis:
Statistical analysis was done using Spearman’s rank coefficient correlation test.

Results:
Mean T-lymphocytes, macrophages, and LC count were significantly higher in lesional skin. The three parameters correlated with vitiligo histological score. T cells were present more frequently in the dermis and stratum basale. Macrophages were found more in the dermis whereas LC was mainly located in the epidermis.

Conclusions:
An increase in the population of inflammatory cells, especially T lymphocytes and LC, may serve as an indicator of unstable vitiligo. The relative distribution of these cells points toward signaling between them and their role in the destruction of melanocytes and keratinocytes. A better understanding of the underlying mechanisms may lead to the development of novel targeted therapies.
Assessment of in vitro antimicrobial activity of ceftazidime-avibactam and phenotypic synergy testing with aztreonam against carbapenem resistant Gram-negative bacilli in a tertiary care hospital
Authors: Mishra Swati , Bhoi Priyadarshini , Choudhary Lipsa , Panigrahy Rajashree , Otta Sarita 
Published: July 2024

Objectives:
Ceftazidime avibactam (CZA) is a drug used against carbapenemase producing Gram-negative bacterial infections. Avibactam (AVI) is a non-beta-lactam-beta-lactamase inhibitor which has no action against metallo-β-lactamase (MBL) enzymes. This inadequacy is counteracted by combining CZA with aztreonam (ATM). The present study aims to denote the in vitro susceptibility pattern of the CZA and CZA-ATM combination in our area.

Materials and Methods:
In this study conducted prospectively from January to June 2023, the samples growing Enterobacterales and Pseudomonas aeruginosa were proceeded for carbapenemase detection by phenotypic testing for EDTA carbapenem inactivation method and modified carbapenem inactivation method. The minimum inhibitory concentration MIC of CZA was determined by E-strip and interpreted as per clinical and laboratory standard institute (CLSI) guidelines, while synergy testing of CZA and ATM was performed using ATM discs.

Statistical Analysis:
All data were entered in Microsoft Excel and analyzed for basic statistics.

Results:
The study included 150 carbapenem resistant organisms (131 Enterobactarales and 19 P. aeruginosa). Among these Enterobacterale strains, 72 (54.9%) were MBL producers. CZA resistance was detected in 69.3% of Klebsiella spp., 61.53% of Escherichia coli, and 50% of Serratia spp. Among Klebsiella spp. and E. coli, 88.9% and 65.2% of MBL isolates showed in vitro synergy to CZA-ATM.

Conclusions:
The study highlights a good in vitro sensitivity pattern of the CZA and ATM combination. However, we also highlight a growing percentage of non-synergistic interactions that need further genetic evaluation.
تطبيق منظومة صناعة العلماء والعلوم والمعرفة السيادية على حالة وطنية
Authors: العبد الجبار عبدالحميد عبدالرحمن , آل سعود بندر عبدالله 
Published: July 2024

تهدف هذه الورقة لتقديم مقترح لتطبيق منظومة وطنية مستدامة لصناعة العلماء وإنتاج العلوم والمعرفة السيادية، مستندة على عمل سابق قدم تصورًا منهجيا لهذه المنظومة. وتبدأ الورقة بعرض خلفية إقليمية تاريخية في مجال الاهتمام بالعلوم وصناعة العلماء ورعايتهم، وفي مجال إنتاج وامتلاك المعرفة السيادية، ونبذة عن الاهتمام المتزايد دوليًا بهذه المنظومة وتطبيقها وتضمينها في السياسات والخطط التنموية. ثم تُوضح علاقة هذه المنظومة بمنظومتي التعليم وريادة الأعمال، ودورها في تحقيق التكامل معهما. وتقدم تحليلًا مفصلًا لتطبيق المنظومة بمكوناتها المختلفة لحالة وطنية محددة ضمن أربعة مجالات تحتوي عناصرها، وهي مجال التخطيط والهيكلة ومجال الممكنات والأدوات ومجال الإنسان ومجال المحتوى المعرفي، حيث يمثل المجالان الأوّلان نطاق المدخلات فيما يمثل الأخيران نطاق المخرجات. ولتوضيح مجالات التطبيق تطرح الورقة بعد ذلك إحدى عشرة مبادرة عملية تشكل في مجموعها أساسًا لتفعيل المنظومة على المستوى الوطني، من أجل الوصول لبيئة تحتضن وترعى التميز والتفوق العلمي وتصنع الكتلة الحرجة المتمثلة في العدد الكافي من العلماء ممن يمتلكون القدرات اللازمة والتمكين، مع الشغف والرؤية والتطلع، لتطوير النظريات العلمية واكتشاف الجديد من الابتكارات والاختراقات العلمية لإنتاج علوم ومعارف تعزز السيادة وتدعم صناعة منتجات حضارية تنافسية. وتؤكد الورقة على أن تناول حالة وطنية محددة، يمنح أفقا لتطبيق هذه المنظومة على دول عربية أخرى.
Recensión a: Carmen Aguarod Otal y J. Carlos Sáenz Preciado (Comis.) (2023). Mucho más que arcilla. El comercio cerámico a través del Hiberus. Catálogo de la exposición.
Authors: Montes López Ruben 
Published: July 2024

Recensión al catalogo realizado por los comisarios Carmen Aguarod Otal y J. Carlos Sáenz Preciado de la exposición: Mucho más que arcilla. El comercio cerámico a través del Hiberus que se expuso en la Sala de Exposiciones "Antigua Rula", del 18 de enero al 21 de abril de 2024) organizada por los Museos Arqueológicos de Gijón y la Fundación Municipal de Cultura, Educación y Universidad Popular.
PROFIL KEMAMPUAN KONEKSI MATEMATIS SISWA KELAS VIII MTS AL KHAIRAAT TONDO PADA MATERI TEOREMA PYTHAGORAS DITINJAU DARI KEMAMPUAN MATEMATIKA
Authors: Anwar Vira Maulina Anwar , Pathuddin  , Alfisyahra  , Rita Lefrida  
Published: July 2024

Penelitian ini bertujuan untuk memperoleh deskripsi mengenai kemampuan koneksi matematis siswa yang berkemampuan matematika sedang. Peneliti tertarik meakukan peneltian ini untuk memperoleh informasi secara deskriptif mengenai kemampuan koneksi matematis siswa kelas VIII MTs Al Khairaat Tondo pada materi teorema Pythagoras. Jenis penelitian ini adalah deskriptif dengan pendekatan kualitatif. Subjek dipilih berdasarkan nilai ulangan harian, MID semester dan rekomendasi guru mata pelajaran. Data diperoleh dari hasil tes tertulis dan wawancara terhadap subjek penelitian. Uji kredibilitas data yang diguakan yaitu member check Hasil penelitian ini menunjukkan bahwa subjek berkemampuan matematika sedang dalam menyelesaikan masalah pada materi teorema Pythagoras berdasarkan indikator koneksi matematis, yakni mampu mengoneksikan antarkonsep matematika, mampu mengoneksikan antar matematika dan fisika dan mampu mengoneksikan matematika dalam kehidupan sehari-hari.