bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encephalitozoon cuniculi causes focal anterior cataract and uveitis in dogs
Authors: Csokai J. , Fuchs-Baumgartinger A. , Maaß G. , Nell B. 
Published: September 2015

SummaryThree mongrel dogs, aged 10 months (case 1), 14 months (case 2) and 7.5 years (case 3), were presented because of ophthalmologic disorders of 4 months, 6 months and 7 years duration, respectively. All three dogs were offspring of stray dogs from Hungary and Serbia and had positive serum antibody titres against Encephalitozoon (E.) cuniculi. The two young dogs showed unilateral, the older dog bilateral chronic anterior uveitis with posterior synechia and focal anterior cortical cataract. The fundi that could be evaluated developed focal tapetal hyporeflective lesions in the course of the disease. Dogs 1 and 2 underwent removal of the lens via phacoemulsification. PCR of the lens material was positive for E. cuniculi strains IV and II, respectively. In dog 2 findings suggestive of microsporidia were detected underneath the anterior lens capsule by immunohistochemical staining. In all cases medical treatment consisted of systemic fenbendazole, prednisolone, and topical anti-inflammatory drugs, and additional brinzolamid/timolol for dog 3. For the time being all cases (follow up 23 months, 6 months and 3 months, respectively) are still on topical anti-inflammatory therapy. It is concluded that E. cuniculi infections can cause cataract and chorioretinal lesions in dogs.
The Metastatic Spine Disease Multidisciplinary Working Group Algorithms
Authors: Wallace Adam N. , Robinson Clifford G. , Meyer Jeffrey , Tran Nam D. , Gangi Afshin , Callstrom Matthew R. , Chao Samuel T. , Van Tine Brian A. , Morris Jonathan M. , Bruel Brian M. , Long Jeremiah , Timmerman Robert D. , Buchowski Jacob M. , Jennings Jack W. 
Published: September 2015

AbstractThe Metastatic Spine Disease Multidisciplinary Working Group consists of medical and radiation oncologists, surgeons, and interventional radiologists from multiple comprehensive cancer centers who have developed evidence- and expert opinion-based algorithms for managing metastatic spine disease. The purpose of these algorithms is to facilitate interdisciplinary referrals by providing physicians with straightforward recommendations regarding the use of available treatment options, including emerging modalities such as stereotactic body radiation therapy and percutaneous tumor ablation. This consensus document details the evidence supporting the Working Group algorithms and includes illustrative cases to demonstrate how the algorithms may be applied.Implications for Practice:The Metastatic Spine Disease Multidisciplinary Working Group algorithms can facilitate interdisciplinary referrals by providing physicians with straightforward recommendations regarding available treatment options, including emerging modalities such as stereotactic body radiation therapy and percutaneous tumor ablation.
Improved Drilling Performance by Applying the China Geosteering Drilling System in Heterogeneous Reservoir Sands: A Case From Songliao Basin, Northeast China
Authors: Gao Wenkai , Zhang Chengguang , Gao Xuesheng , Lin Yushui , Sheng Limin , Dou Xiurong , Jia Hengtian , Yan Guoxing 
Published: September 2015

Abstract
Directional wells and cluster wells have become a conventional drilling technique now, which is widely used in various types of oil and gas reservoirs. Each year, more than half of the total drilling are directional wells in China. The main work is not to aim the target area, but to track the reservoirs now. Geosteering drilling is an important technical approach to improve single-well production and recovery ratio, to achieve the “less wells more production” idea.
China Geosteering Drilling System (CGDS), integrated the technology of drilling with logging and reservoir engineering, applies the near-bit geological and engineering parameters as well as controlling method to ensure that the wellhole trajectory can pass through reservoir and get best location while drilling. The wellhole trajectory can be adjusted and controlled timely according to the formation features measured by CGDS. The drilling bit is equipped with “eyes”, which can identify oil/gas layer during drilling.
Since 2011, we have provided CGDS geosteering services in 29 horizontal wells in Songliao Basin. The total footage reached 18255m, and the longest footage in horizontal section was 1325m in single well, while the average sand penetration rate is above 85%. Comparing with the horizontal wells operated by conventional LWD tools in the same block, the results of the field application shows that the CGDS geosteering system can significantly improve sand penetration rate and substantially reduce the drilling duration.
On the basis of introduction to the system, this paper focuses on comparative analysis of significant application effect of CGDS geosteering system for the heterogeneous reservoir in Putaohua Area of Songliao Basin, as well as the lessons learned. Helpful case histories will also be presented.
Safety Critical Tasks: Identification of Human Error to Control Risks from Major Accident Hazards
Authors: Petrie George , Rosbrook Ann 
Published: September 2015

Abstract
Although the importance of human failures in causing accidents is well known in the Oil & Gas industry, historically the focus in safety cases or site safety reports has been less on human failures than on technical failures in major accident hazards (MAH).
In order to address this disparity the Company has developed a process to manage the risk of human error across their assets. This is primarily for mature tasks and activities that is things that are currently done and have been for some time, as well as new tasks and activities from projects and modifications. This involves developing a robust process to select specific activities where Major Accident Hazard (MAH) scenarios had been identified from the various safety studies. Progress at first has been slow but by developing sound foundations the company has started to show significant benefits in managing human failures that may lead to MAH scenarios.
This paper describes and details how this process has gained momentum by the Company providing dedicated resources to support the assessment process and to facilitate updates to site procedures. This work involves both operators and maintenance technicians in the analysis and site walk- and-talk through of the task. The process has identified safety related risks that were not previously recognised and significant environmental risks, operational risks (equipment damage, process upsets) and potential downtime of plant. A key benefit of employee involvement is that employees are actively involved in human error analysis in their day-to-day activities and recognise where human error is critical as well as the true value of maintaining key recovery systems Key learning points and case studies are described in order that they can be used by other organisations to assist in any application of the process.
This process is very much work in progress. However, foundations have been developed to ensure lessons are learned and to ensure a standard approach to using a human factors approach to manageging MAH across the organisation.
Application Of Distributed Horizontal Drill Stem Pulse Tests To The Appraisal Of Naturally Fractured Resource In The Devonian Clair Group
Authors: Costaschuk J. , Robertson A. , von Schroeter T. , Sweeney K. , Waili I. , Pieterson R. 
Published: September 2015

Abstract
This paper describes the first known offshore application of distributed horizontal pulse testing. This technique appraises the deliverability of naturally fractured resource, using only a single penetration and Drill Stem Test (DST) string run. Central to the design is the ability to collect near real-time interference data at a known minimum length from a drawdown interval. The pulse test is distributed in that the signal and observation zones can be swapped on demand from surface, acoustically via sleeve. BP successfully applied this technique to two appraisal wells in their 2014 offshore drilling operations.
The dual zone DST pulse testing method is a new approach to the appraisal of naturally fractured reservoirs. It was developed to create a real-time interference dataset outwith the active production interval, i.e. within a passive zone. The formation is produced (and rate data are measured) in two spatial locations and across two known length-scales (by swapping the active and passive zones prior to commingling). Pressure diffusivity can thus be calibrated to data measured in two spatial locations of the same reservoir, and not just one, as per a conventional test design, i.e. enabling a history match of the pressure response of two lateral zones from a pulse signal in one. The horizontal aspect is achieved via high-angle well, drilled sub-parallel to unit bedding (Figure 1).
With the double staging approach (upper and lower zones), which has been developed for fractured reservoir appraisal studies, three tests were successfully performed in each appraisal well: two partial penetration tests on discrete short intervals (DST#1a, DST#1b), and one final test on a longer interval that included both of the short intervals (DST#1c). Results of this application have demonstrated that pressure diffusivity can be derived from pressure data that are measured simultaneously in two spatial locations, within and outwith an active production interval. This has proved particularly useful for reducing the degrees of freedom in reservoir model identification. The paper concludes that appraisal of naturally fractured reservoir might be sub-optimal in a DST design where drawdown and observation data are limited to a singular inflow zone only.
This is the first known application in the industry where one DST run has successfully yielded six unique appraisal data types, gathered simultaneously at both intra/inter zone and commingled length-scales. These data are conventionally not gathered in a single zone design, i.e. without the ability to selectively inflow and monitor pressure in each discrete lateral zone. Consequently this technique has significantly improved the description of both static and dynamic reservoir properties and reduced development uncertainty, all at a relatively low incremental cost.
Novel Interpretation of Downhole Monitoring Data for Horizontal Wells Equipped with Intelligent Completions
Authors: Liu Guangwei , Jiang Hanqiao , Shi Shuaishuai , Li Junjian , Ding Shuaiwei , Fang Wenchao 
Published: September 2015

AbstractHorizontal well is an important technology to enhance oil recovery for both old oilfield and new oilfield. Horizontal well have four characteristics: large drainable area; small producing pressure drop; high fluid productivity index and long water free production period (Joshi S. D. 1991) compared with vertical well. The contact pattern between horizontal section and the layer is line contact, and the pressure drop around the horizontal section is a linear distribution. The pressure drop near the bottom of the horizontal well will be far less than that of the vertical well if the same fluid is produced. Therefore, horizontal well can inhibit bottom water coning more effectively. The critical production of horizontal well is greater than that of vertical well for bottom water reservoir(Chaperon 1986, Papatzacos P. et al. 1991). But horizontal well may form water cresting. The reserves controlled by the horizontal section and volume swept by the bottom water is far larger than that of the vertical well, so it can increase the cumulative water free production. Therefore, comparing with vertical well, horizontal well can prolong water breakthrough time and improve the ultimate recovery (Permadi P et al. 1995, Wibowo W et al. 2004), which is one of the reasons for horizontal well technology used in bottom water reservoir widely at home and abroad. But with the oilfield development, horizontal well has also exposed some questions gradually. Vertical well has a long water cut production period, but water cut of the horizontal well increase dramatically after water breakthrough, which affected horizontal well development seriously (Souza A L S. 1997).
Internal Governance and Real Earnings Management
Authors: Cheng Qiang , Lee Jimmy , Shevlin Terry 
Published: September 2015

ABSTRACT
We examine whether internal governance affects the extent of real earnings management in U.S. corporations. Internal governance refers to the process through which key subordinate executives provide checks and balances in the organization and affect corporate decisions. Using the number of years to retirement to capture key subordinate executives' horizon incentives and using their compensation relative to CEO compensation to capture their influence within the firm, we find that the extent of real earnings management decreases with key subordinate executives' horizon and influence. The results are robust to alternative measures of internal governance and to various approaches used to address potential endogeneity, including a difference-in-differences approach. In cross-sectional analyses, we find that the effect of internal governance is stronger for firms with more complex operations where key subordinate executives' contribution is higher, is enhanced when CEOs are less powerful, is weaker when the capital markets benefit of meeting or beating earnings benchmarks is higher, and is stronger in the post-SOX period. This paper contributes to the literature by examining how internal governance affects the extent of real earnings management and by shedding light on how the members of the management team work together in shaping financial reporting quality.
JEL Classifications: G32; M40.
Transfer accuracy of vinyl polysiloxane trays for indirect bonding
Authors: Grünheid Thorsten , Lee Michael S. , Larson Brent E. 
Published: September 2015

ABSTRACT

Objective:
To elicit the magnitude, directional bias, and frequency of bracket positioning errors caused by the transfer of brackets from a dental cast to the patient’s dentition in a clinical setting.

Materials and Methods:
A total of 136 brackets were evaluated. The brackets were placed on dental casts and scanned using cone beam computed tomography (CBCT) to capture 3-D positioning data. The brackets were then transferred to the patient’s dentition with an indirect bonding method using vinyl polysiloxane (VPS) trays and later scanned using CBCT to capture the final bracket positioning on the teeth. Virtual models were constructed from the two sets of scan data and digitally superimposed utilizing best-fit, surface-based registration. Individual bracket positioning differences were quantified using customized software. One-tailed t tests were used to determine whether bracket positioning was within limits of 0.5 mm in the mesiodistal, buccolingual, and vertical dimensions, and 2° for torque, tip, and rotation.

Results:
Individual bracket positioning differences were not statistically significant, indicating, in general, final bracket positions within the selected limits. Transfer accuracy was lowest for torque (80.15%) and highest for mesiodistal and buccolingual bracket placement (both 98.53%). There was a modest directional bias toward the buccal and gingival.

Conclusion:
Indirect bonding using VPS trays transfers the planned bracket position from the dental cast to the patient’s dentition with generally high positional accuracy.
Small Incision Lenticule Extraction After Deep Anterior Lamellar Keratoplasty
Authors: Mastropasqua Leonardo , Calienno Roberta , Lanzini Manuela , Nubile Mario 
Published: September 2015

PURPOSE:
Femtosecond laser-assisted small incision lenticule extraction (SMILE) was performed to correct myopic astigmatism in a 39-year-old patient who had previously undergone deep anterior lamellar keratoplasty (DALK) for keratoconus, with clinically significant anisometropia and contact lens intolerance.

METHODS:
Case report.

RESULTS:
SMILE was planned in the right eye to reduce the refractive error and to allow spectacle correction. The surgical procedure was centered on the visual axis, a 5.20-mm optical zone was used, and the refractive lenticule was extracted through a 3.25-mm incision located inside the graft edge. The refractive target was achieved 1 week after surgery and remained stable until the 3-month follow-up visit, while the corrected distance visual acuity improved from 20/100 to 20/40. Complications were not observed and the graft remained clear. In vivo confocal microscopy and anterior segment optical coherence tomography highlighted a regular wound healing and refractive interface profile.

CONCLUSIONS:
This case report highlights the feasibility of using SMILE as an alternative procedure for correcting refractive errors after keratoplasty, but further prospective studies are needed to prove the long-term refractive outcomes and safety of this technique.

[
J Refract Surg.
2015:31(9):634–637.]
Relation between DNA damage measured by comet assay and OGG1 Ser326Cys polymorphism in antineoplastic drugs biomonitoring
Authors: Ladeira Carina , Viegas Susana , Pádua Mário , Carolino Elisabete , Gomes Manuel C. , Brito Miguel 
Published: September 2015

AbstractAntineoplastic drugs are hazardous chemical agents used mostly in the treatment of patients with cancer, however health professionals that handle and administer these drugs can become exposed and develop DNA damage. Comet assay is a standard method for assessing DNA damage in human biomonitoring and, combined with formamidopyrimidine DNA glycosylase (FPG) enzyme, it specifically detects DNA oxidative damage.The aim of this study was to investigate genotoxic effects in workers occupationally exposed to cytostatics (n = 46), as compared to a control group with no exposure (n = 46) at two Portuguese hospitals, by means of the alkaline comet assay. The potential of the OGG1 Ser326Cys polymorphism as a susceptibility biomarker was also investigated. Exposure was evaluated by investigating the contamination of surfaces and genotoxic assessment was done by alkaline comet assay in peripheral blood lymphocytes. OGG1 Ser326Cys (rs1052133) polymorphism was studied by Real Time PCR.As for exposure assessment, there were 121 (37%) positive samples out of a total of 327 samples analysed from both hospitals. No statistically significant differences (Mann-Whitney test, p > 0.05) were found between subjects with and without exposure, regarding DNA damage and oxidative DNA damage, nevertheless the exposed group exhibited higher values. Moreover, there was no consistent trend regarding the variation of both biomarkers as assessed by comet assay with OGG1 polymorphism. Our study was not statistically significant regarding occupational exposure to antineoplastic drugs and genetic damage assessed by comet assay. However, health professionals should be monitored for risk behaviour, in order to ensure that safety measures are applied and protection devices are used correctly.
Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody
Authors: van Montfort Thijs , Thomas Adri A. M. , Krawczyk Przemek M. , Berkhout Ben , Sanders Rogier W. , Paxton William A. 
Published: September 2015

AbstractAb-neutralized HIV-1 can be captured by dendritic cells (DCs), which subsequently transfer infectious HIV-1 to susceptible CD4+ T cells. In this study, we examined the capacity of early Abs, as well as recently identified broadly neutralizing Abs (bNAbs) targeting different envelope glycoprotein (Env) epitopes, to block HIV-1 transmission by immature and mature DCs to HIV-1–sensitive cells. Three bNAbs directed against the gp41 membrane proximal region of Env (2F5, 4E10, and 10E8) and three gp120 bNAbs targeting the CD4 binding site (b12, VRC01, and NIH45-46) were examined. In addition, eight glycan-dependent bNAbs targeting the V1V2 apex (PG9, PG16, and PGT145), the V3 loop (2G12, PGT121, and PGT128), and the gp120–gp41 interface of Env (PGT151 and 35O22) were tested. bNAbs that bound specific glycans showed, depending on the immature or mature state of the DC, diverse efficiencies in HIV-1 trans-infection. All bNAbs that bound the CD4 binding site blocked trans-infection, whereas all bNAbs directed against the membrane proximal region lost neutralizing activity after DC-mediated HIV-1 transmission. To understand how preneutralized HIV-1 can be transferred as infectious virus by DCs, we followed the processing of 2F5-treated HIV-1 by DCs with confocal microscopy. Inhibition of DC-internalization pathways could not reverse the dissociation of 2F5 from HIV-1, suggesting that Ab dissociation occurs directly at the plasma membrane. Collectively, these findings imply that the location of the epitope and the neutralization capacity of these Abs determine the efficiency of DC-mediated HIV-1 transfer.
IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response
Authors: Cohen Heather B. , Ward Amanda , Hamidzadeh Kajal , Ravid Katya , Mosser David M. 
Published: September 2015

Abstract
The priming of macrophages with IFN-γ prior to TLR stimulation results in enhanced and prolonged inflammatory cytokine production. In this study, we demonstrate that, following TLR stimulation, macrophages upregulate the adenosine 2b receptor (A2bR) to enhance their sensitivity to immunosuppressive extracellular adenosine. This upregulation of A2bR leads to the induction of macrophages with an immunoregulatory phenotype and the downregulation of inflammation. IFN-γ priming of macrophages selectively prevents the induction of the A2bR in macrophages to mitigate sensitivity to adenosine and to prevent this regulatory transition. IFN-γ–mediated A2bR blockade leads to a prolonged production of TNF-α and IL-12 in response to TLR ligation. The pharmacologic inhibition or the genetic deletion of the A2bR results in a hyperinflammatory response to TLR ligation, similar to IFN-γ treatment of macrophages. Conversely, the overexpression of A2bR on macrophages blunts the IFN-γ effects and promotes the development of immunoregulatory macrophages. Thus, we propose a novel mechanism whereby IFN-γ contributes to host defense by desensitizing macrophages to the immunoregulatory effects of adenosine. This mechanism overcomes the transient nature of TLR activation, and prolongs the antimicrobial state of the classically activated macrophage. This study may offer promising new targets to improve the clinical outcome of inflammatory diseases in which macrophage activation is dysregulated.
Intra-operative neurophysiological monitoring
Authors: Ali Zulfiqar , Bithal Parmod 
Published: September 2015

AbstractIntraoperative neurophysiological monitoring has achieved importance due to complexity of cranio-spinal surgical procedures being performed frequently these days. Many studies have proven a decreased neurological complication rate after its introduction. It is broadly of two types: Sensory evoked potentials and motor evoked potentials which are further sub-divided. Its use during surgery requires a controlled anaesthesia technique with no or minimal influence on its recording. Its success depends upon three way communication among the surgeon the neurophysiologist and the anaesthesiologist.