bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Multi-Targeted Pharmacological profile of an Exopolysaccharide from Bacillus rugosus SYG20 via In Vitro Evaluation of its Antioxidant, Anti-inflammatory, Anti-diabetic, Wound Healing, and Antimicrobial Properties
Authors: Alharbi Maha A. , Shahlol Aisha M.A , Albureikan Mona Othman I. , Johani Khalid , Elsehrawy Mohamed Gamal , El-Nablaway Mohammad , Saleh Fayez M. , Basyony Ahmed Farouk , Zakai Shadi A. , Ghareeb Ahmed 
Published: July 2024

IntroductionExopolysaccharides (EPSs) derived from marine microorganisms are a newly recognized reservoir of bioactive therapeutic compoundsMaterial and methodsWe isolated a high EPS-yielding bacterial strain from the Red Sea, identified as Bacillus rugosus SYG20. Its purified EPS (EPSR9) contains 45.33% uronic acid, 9.98% sulfate groups, and 5.40% N-acetyl glucosamine. The HPLC chromatogram revealed four monosaccharides - glucose, xylose, galacturonic acid, and arabinose, in a distinct molar ratio of 2:3:1:1. EPSR9 showed a wide array of bioactivities.ResultsIt displayed antioxidant activity with an IC50 of 25.6 μg/ml in the DPPH assay and a total antioxidant capacity (TAC) of 417.77μg/ml equivalent AAE and 62.67 μg/ml equivalent AAE in Ferric reducing antioxidant power (FRAP) assays. It exhibited substantial anti-inflammatory properties. The anticoagulant effect of the EPS was demonstrated by a dose-dependent increase in prothrombin time. The scratch assay resulted in a 72.66% increase in wound closure, promoting in vitro wound healing after 48 h. Anti-obesity activity was evidenced by 83.8% lipase inhibition at 1000 μg/ml with IC50 of 107.73μg/ml. EPSR9 demonstrated inhibitory effects on α-amylase with an IC50 value of 14.37μg/ml and α-glucosidase with an IC50 value of 26.73 μg/ml, highlighting its potential as an anti-diabetic agent. Then, EPS showed bactericidal properties with MBC/MIC≤2 against both G+ve and G-ve bacteria, Staphylococcus aureus , Enterococcus faecalis (MIC=3.9μg/ml), Salmonella typhi, and Helicobacter pylori.ConclusionsThe marine EPSR9 exhibited considerable potential for pharmaceutical applications as a multi-bioactive microbial metabolite. Its in vivo potency and mechanisms of action warrant further investigation.
CAUSES OF TEACHER ABSENTEEISM IN SELECTED SECONDARY SCHOOLS OF KAYUNGA DISTRICT IN UGANDA. A DESCRIPTIVE STUDY.
Authors: Gasiwo Moses Magoola , Beinomugisha Dr. Peninah 
Published: July 2024

Background:
Teacher absenteeism is when the teacher is out of school either by delaying, leaving before official closing time, not attending school at all, or when the teacher is at school but missing classes. Absenteeism is caused by many factors like personal illness, a relative’s sickness, family conflicts, lack of job satisfaction leading to low morale, lack of personal competence, lack of friendly work group norms, poor leadership at the workplace, in effective supervision and inspection, assignment of other duties outside the workplace, bad weather conditions, union influence, and poor working conditions. The study aims to examine the causes of absenteeism in selected secondary schools of Kayunga District in Uganda.
Methodology:
This is a descriptive survey design in which quantitative research methods were used on 210 who included the DEO, 10 head teachers, 100 teachers, and 100 Students.
Results:
54.0% of the respondents were male while 46.0% were females. According to teacher responses, 67% agreed that female teachers are usually absent due to family responsibilities, and 58% agreed that male teachers are usually absent because of attending their business to substitute for their income. 52% agreed that old teachers are mostly absent because they lost their morale.64% of the teachers agreed that teachers are absent due to illness. 46% of teachers agreed that teachers of low level of education attend further education programs. (46%) agreed that teachers absent themselves because they are not satisfied with their job.
Conclusion:
Teachers absent themselves because they are unsatisfied with their jobs, family responsibilities, substitute income, undertaking further studies, lost morale, and are tired and some miss due to illness.
Recommendation:
School employers should ensure that there is constant supervision and remuneration to motivate teachers as a way of curbing teachers’ absenteeism.
Das Rätsel um den Bormangel
Authors: Schaal René 
Published: July 2024

Frankfurt a.M. Raps und verwandte Pflanzen haben einen hohen Bedarf an Bor. Einen Bormangel sieht man den betroffenen Pflanzen äußerlich lange nicht an, insbesondere in der Wachstumsphase vor der Blüte.
Uji Aktivitas Antibakteri Ekstrak Etanol 70% Daun Ginseng Jawa (Talinum paniculatum (Jacq.) Gaertn) Terhadap Bakteri Shigella dysenteriae
Authors: Oktaviani Riwanda , Fitriyanti Fitriyanti , Sari Putri Kartika 
Published: July 2024

Shigellosis merupakan infeksi saluran pencernaan yang dapat disebabkan oleh bakteri S dysenteriae. Ginseng jawa (T. paniculatum (Jacq.) Gaertner) adalah salah satu tumbuhan yang diketahui berpotensi antibakteri. Penelitian ini bertujuan untuk mengetahui kandungan golongan senyawa yang terdapat pada ekstrak etanol 76% daun ginseng jawa serta melihat aktivitas antibakteri ekstrak etanol 70% daun ginseng jawa terhadap S. dysenteriae berdasarkan nilai diameter zona hambatnya. Pengujian antibakteri dengan metode difusi cakram dengan enam variasi konsentrasi ekstrak diantaranya 5%, 10%, 20%, 40%, 60% serta 80% untuk kontrol positif dan negatif yang digunakan adalah Azithromycin 15µg/disk dan Na-CMC 0,5%. Identifikasi kandungan senyawa metabolit sekunder dilakukan terhadap senyawa alkaloid, fenol, flavonoid, kuinon, saponin, steroid/triterpenoid serta tanin. Hasil uji skrining ekstrak etanol 70% daun ginseng jawa terdapat senyawa flavonoid, fenol, saponin, steroid serta tanin. Pengujian antibakteri pada konsentrasi terkecil yaitu 5% zona hambat termasuk lemah dengan rata-rata diameter penghambatan sebesar 4,01 mm dan pada konsentrasi terbesar yaitu 10% zona hambat termasuk kuat dengan rata-rata diameter zona hambat 11,26 mm.
A Pragmatic Analysis of Conversational Implicatures in English Drama and their Role in Teaching Critical Literacy
Authors: Nkurunziza Bonaventure , Ngoboka Jean Paul , Habyarimana Hilaire 
Published: July 2024

This study aims to explore the role of conversational implicatures in English drama in developing students’ critical literacy. It identified conversational implicatures conveyed by characters of the selected drama texts, provided possible interpretations of the implicatures basing on Grice’s Cooperative Principle maxims, and critically analyzed the role of conversational implicatures in English drama in developing students’ critical literacy. The data were collected from the implicatures conveyed by the characters of two selected drama texts. These are ‘Family Abuse’ by Bernard Mersier and ‘The Edge’ by Paul Symonloe. Grice’s pragmatic theory of Cooperative Principle and its maxims were used to identify and interpret conversational implicatures in the selected drama texts. Forty-two (42) conversational implicatures were identified from these texts. These implicatures were categorized into types basing on the four conversational maxims, and each conversational implicature was taken as data. Using Grice’s interpretive model and the social context of the drama, what the characters implied by their utterances were explained together with the reasons for the implicatures. The Luke and Freebody’s four resources model of critical literacy was then used to study the role of conversational implicatures in English drama in developing students’ critical literacy. The study concluded that conversational implicatures in English drama develop students’ critical literacy by enabling them to study a drama text from a social angle and evaluate the social aspects that may have influenced the meaning of the characters ‘utterances. Therefore, it was suggested that drama texts should be used in language teaching and learning as they ease the teaching of conversational implicatures which can foster the development of students’ critical literacy.
ОҚЫТУДА ВИРТУАЛДЫ ШЫНАЙЫЛЫҚТЫ ПАЙДАЛАНУ КЕЗІНДЕГІ ЫҚТИМАЛ МӘСЕЛЕЛЕР
Authors: Өмірзақова А.А. , Калкабаева З.К. , Мукашева М.У. , Казангапова Л.К. , Найманова Д.С. 
Published: July 2024

Актуальность исследования обусловлена растущим интересом педагогического, медицинского, психологического и родительского сообщества к вопросам безопасности школьного образования в условиях масштабной цифровой трансформации общества. В этом контексте изучение влияния виртуальной реальности на физическое и психическое здоровье обучающихся является одним из важных направлений современного образования. В статье представлены некоторые результаты эмпирического исследования поведения и общего физического состояния учащихся 5-11 классов при их погружении в виртуальную реальность. Предполагается, что результаты будут способствовать выявлению и устранению возможных проблемв использовании виртуальной реальности в образовании, в том числе и в общеобразовательной школе.
Зерттеудің өзектілігі педагогикалық, медициналық,психологиялық және ата-аналар қауымдастығыныңқоғамның ауқымды цифрлық трансформациясы жағдайында мектептегі білім беру қауіпсіздігімәселелеріне қызығушылығының артуына байланысты. Бұл тұрғыда виртуалды шынайылықтың оқушылардың физикалық және психологиялық денсаулығына әсерін зерттеу виртуалды шынайылық саласындағы маңызды бағыттардың бірі болып табылады. Мақалада виртуалды шынайылыққа ену кезіндегі 5-11 сынып оқушыларының мінез-құлқы мен жалпы физикалық жағдайын эмпирикалық зерттеудің кейбір нәтижелері келтірілген. Нәтижелер білім беруде, оның ішінде жалпы білім беретін мектепте виртуалды шынайылықты пайдаланудағы ықтимал мәселелерді анықтауға және оның алдын-алуға ықпал етеді деп болжануда.
The relevance of the study is due to the growing interest of the pedagogical, medical, psychological and parental community in the safety of school education in the context of a large-scale digital transformation of society. In this context, the study of the impact of virtual reality on the physical and psychological health of students is one of the important directions in the field of virtual reality. The article presents some results of an empirical study of the behavior and general physical condition of students in grades 5-11 when immersed in virtual reality. It is assumed that the results will contribute to the identification of possible risks in the use of virtual reality in education, including in secondary schools.
FENDA FACIAL DIAGNOSTICADA NO PRÉ-NATAL: ASPECTOS EPIDEMIOLÓGICOS, ULTRASSONOGRÁFICOS E PÓS-NATAIS
Authors: Requeijo Márcio José Rosa , Penoni Karoline Zanitti , Ruano Rodrigo , Bunduki Victor , Lopes Marco Antônio Borges , Francisco Rossana Pulcineli Vieira , Zugaib Marcelo 
Published: July 2024

A fenda facial sempre intrigou a sociedade por ser uma malformação que estigmatiza seus portadores. Os poucos dados relacionados à observação ultrassonográfica pré-natal dessa malformação, no Brasil, incentivaram o seu estudo no Setor de Medicina Fetal do departamento de ginecologia e obstetrícia do hospital das clínicas da faculdade de medicina da universidade de São Paulo (DOG, HCFMUSP). Métodos e objetivos: O estudo foi desenvolvido de maneira descritiva, sendo selecionados 97 fetos portadores de fenda facial diagnosticada ao ultrassom morfológico no Setor de Medicina Fetal da Clínica Obstétrica do DOG da HCFMUSP, sendo divididos em três grupos específicos: grupo I (fenda facial isolada), grupo II (fetos com fenda facial e outras malformações associadas) e grupo III (fenda facial cursando com aneuploidia) com o objetivo de estudar as características destes grupos separadamente e em conjunto. Resultados: Houve confirmação do diagnóstico ultrassonográfico no pós-natal do tipo de fenda facial em 88,7%; idade materna no diagnóstico de 27,8 ± 7,8 anos; idade gestacional no diagnóstico de 27,4 ± 5,9 semanas; fraca relação com história familiar; prevalência da fenda lábio palatina; prevalência da fenda labial esquerda na fenda facial isolada (grupo I) e da fenda lábio palatina mediana na fenda facial associada a outras malformações (grupo II) e também na fenda facial associada à aneuploidia (grupo III); a fenda labial e a fenda lábio palatina foram prevalentes no sexo masculino e a fenda palatina isolada no sexo feminino; maior associação com malformações musculoesqueléticas, cardíacas e holoprosencefalia; prevalência da associação com trissomia do 13; idade gestacional média no parto de 33,5 ± 6,3 semanas, sendo de 38,8 ± 1,17 semanas no grupo de fenda facial isolada (grupo I); peso fetal médio ao nascimento de 2,105 g ± 1086g, sendo de 3,027 ± 1910g no grupo de fenda facial isolada (grupo I); mortalidade na presença da fenda facial de 71,7 % com índice de mortalidade de 95,4 % na fenda facial associada a outras malformações (grupo II) e índice de mortalidade de 100% na fenda facial associada a aneuploidia ( grupo III), sendo que não houve óbito no grupo da fenda facial isolada (grupo I). Conclusão: Houve uma excelente correlação entre o tipo de fenda facial diagnosticada pela ultrassonografia no período gestacional e o tipo de fenda facial observado no pós-natal, sendo a avaliação do palato foi o maior problema técnico para o diagnóstico da fenda facial. A idade gestacional no diagnóstico da fenda facial foi tardia e fetos com fenda facial isolada apresentaram bom prognóstico, com idade gestacional no nascimento e peso compatível com o termo. Fetos com outras malformações, independente de presença de aneuploidia, apresentaram mal prognóstico, com altíssima letalidade e tendência à prematuridade e baixo peso.
Prácticas ambientales de Responsabilidad Social Empresarial en empresas familiares de la provincia de El Oro. Caso de estudio BANARAF S. A.
Authors: Vizueta Matamoros Gabriela Katherine , Pérez Espinoza María José , Espinoza Carrión Cecibel del Rocío 
Published: July 2024

En la actualidad las empresas se han visto en la necesidad de ser socialmente responsables adoptando diferentes iniciativas, cumpliendo con códigos y normas para promover un comportamiento más ético, respetuoso con la comunidad y el medio ambiente y contribuir a la sostenibilidad. El presente informe de investigación forma parte de los resultados y actividades desarrolladas dentro del proyecto de investigación de la carrera de Administración de Empresas, de la Universidad Metropolitana Sede Machala, y tiene un doble propósito. Por una parte, desde el punto de vista teórico, se persigue revisar e identificar los aspectos clave de las prácticas de Responsabilidad Social especialmente en empresas de propiedad familiar. Por otro lado, desde el punto de vista empírico, se pretender obtener información que permita concluir con la identificación de los aspectos principales que contempla la responsabilidad social empresarial desde las dimensiones, social, humana, económica y ambiental y los beneficios que ha obtenido la empresa familiar. Para el desarrollo de la presente investigación se ha utilizado la investigación cualitativa utilizando un grupo de discusión como técnica de recolección de datos para finalmente concluir que las prácticas de Responsabilidad Social Empresarial son importantes en empresas familiares porque ayudan a preservar el legado familiar, mejoran la imagen y reputación, y contribuyen a la sostenibilidad a largo plazo. Al adoptar una perspectiva responsable, las empresas familiares pueden generar beneficios tanto económicos como sociales, y marcar la diferencia en su entorno.
Plataformas LMS para satisfacer las necesidades actuales de capacitación laboral online en las empresas
Authors: Trejo González Dulce María 
Published: July 2024

La nueva normalidad global, después de un largo tiempo de cuarentena por la pandemia del Covid-19, trajo consigo la adaptación de nuestras actividades rutinarias ahora en escenarios virtuales, prueba de ello es la capacitación del personal de una organización, donde se abrió un área de oportunidad de beneficio costo para seguir cumpliendo con la capacitación del personal, sin interrumpir la totalidad de sus funciones laborales; la presente investigación tiene como finalidad comparar las diversas plataformas LMS (Learning Management System o Sistema de gestión del aprendizaje), y poder ver los servicios novedosos que ofrecen para ofertar los cursos de capacitación en línea (e-training) , mediante una investigación documental asentada en revisiones bibliográficas que sustenten una recomendación de plataformas más acordes a las necesidades actuales de capacitación laboral en las empresas.
A 2-year intercomparison of three methods for measuring black carbon concentration at a high-altitude research station in Europe
Authors: Tinorua Sarah , Denjean Cyrielle , Nabat Pierre , Pont Véronique , Arnaud Mathilde , Bourrianne Thierry , Dias Alves Maria , Gardrat Eric 
Published: July 2024

Abstract. Black carbon (BC) is one of the most important climate forcers with severe health effects. Large uncertainties in radiative forcing estimation and health impact assessment arise from the fact that there is no standardized method to measure BC mass concentration. This study presents a 2-year comparison of three state-of-the-art BC measurement techniques at the high-altitude research station Pic du Midi (PDM) located in the French Pyrenees at an altitude of 2877 m above sea level. A recently upgraded Aethalometer AE33, a thermal-optical analyser Sunset and a single-particle soot photometer SP2 were deployed to measure simultaneously the mass concentration of equivalent black carbon (MeBC), elemental carbon (MEC) and refractory black carbon (MrBC), respectively. Significant deviations in the response of the instruments were observed. All techniques responded to seasonal variations in the atmospheric changes in BC levels and exhibited good correlation during the whole study period. This indicates that the different instruments quantified the same particle type despite the fact that they are based on different physical principles. However the slopes and correlation coefficients varied between instrument pairs. The largest biases were observed for the AE33 with MeBC values that were around 2 times greater than MrBC and MEC values. The principal reasons of such large discrepancy were explained by the mass absorption cross section (MAC) that was too low and C values recommended by the AE33 manufacturer and applied to the absorption coefficients measured by the AE33. In addition, the long-range transport of dust particles at PDM in spring caused significant increases in the bias between AE33 and SP2 by up to a factor 8. The Sunset MEC measurements agreed within around 17 % with the SP2 MrBC values. The largest overestimations of MEC were observed when the total carbon concentrations were below 25 µg C cm−2, which is probably linked to the incorrect determination of the organic carbon (OC)–EC split point. Another cause of the discrepancy between instruments was found to be the limited detection range of the SP2, which did not allow for the total detection of fine rBC particles. The procedure used to estimate the missing mass fraction of rBC not covered by the measurement range of the SP2 was found to be critical. We found that a time-dependent correction based on fitting the observed rBC size distribution with a multimodal lognormal distribution is needed to accurately estimate MrBC over a larger size range.
Peningkatan Pengetahuan Kesehatan Tentang Pencegahan Skabies Pada Anak Panti Asuhan Tahun 2022
Authors: Haerani Rani , Deli Lilia  , Fera Novitry  
Published: July 2024

Skabies yaitu salah satu penyakit kulit yang di sebabkan oleh tungau (Sarcoptes scabiei var. hominis) menjadi penyebab rasa gatal yang hebat, Area padat penghuni seperti panti asuhan menjadi tempat penyakit skabies ditemukan, sedangkan pengetahuan tentang penyakit skabies serta penanggulangannya tidak diedukasikan di panti asuhan. Tujuan penelitian untuk mengetahui dampak pelatihan kesehatan atas wawasan anak panti asuhan atas menekan penjangkitan scabies di panti asuhan. Penelitiannya memakai quasy eksperimental melalui pretest-posttest design. Populasi dalam penelitiannya yaitu anak Panti Asuhan Muhammadiyah Annur Baturaja yang berjumlah 40 anak. Sampel dalam penelitian dengan cara accidental sampling. Diperoleh 39 narasumber. Keterangan penelitiannya diraih atas kuesioner yang diberikannya ke narasumber sebelum serta setelah pelatihan kesehatan. Temuan pada penelitiannya memastikan bahwa narasumber berumur 15 tahun (23,1%) adalah responden terbanyak. Analisa dampak pelatihan kesehatan atas tingkatan wawasan anak panti asuhan atas menangkal penjangkitan scabies memakai uji Wilcoxon diperoleh skor signifikansi besarnya 0,000. Bisa dikesimpulkan maka penyuluhan kesehatan memiliki dampak atas tingkatan wawasan serta kelakuan santri atas menangkal penjangkitan skabies di Panti Asuhan Muhammadiyah Annur Baturaja.
Performance Analysis of Non-Communicable Disease Integrated Care Post Cadres at Community Health Centres
Authors: Hidayati Wahyu , Lilis Suryani  , Arie Wahyudi  , Ali Harokan  
Published: July 2024

The implementation of the Posbindu PTM programme encounters many obstacles such as insufficient facilities and infrastructure, lack of training and limited human resources, This study aims to determine the factors associated with the performance of Posbindu PTM cadres at the Martapura Health Centre. This research is quantitative with a crossectional approach. The population of this study were cadres Posbindu PTM in Martapura Year 2024. The sample in this study amounted to 60 people. The sampling method uses total sampling. This research was conducted on 22 February - 15 March 2024. Data collection techniques by interview using a questionnaire. Bivariate data analysis using Chi-Square test and multivariate using logistic regression test. The results showed that there was a relationship between motivation (p value 0.006) and training (p value 0.00) on the performance of NCD posbindu cadres at Puskesmas Martapura, East Ogan Komering Ulu Regency in 2024. There is no relationship between age (p value 0.59), attitude (p value 0.21) and supervision (p value 0.46) to the performance of NCD posbindu cadres at Puskesmas Martapura, East Ogan Komering Ulu Regency in 2024. The most dominant factor with the performance of cadres posbindu NCD at Puskesmas Martapura East Ogan Komering Ulu Regency Year 2024 is motivation (p value 0.004) (Odds Ratio 0.179). Conclusion there is a relationship between motivation and training on the performance of cadres posbindu NCD at Puskesmas Martapura East Ogan Komering Ulu Regency Year 2024. Suggestions for Puskesmas should provide motivation to cadres posbindu PTM, such as giving appreciation or reward to cadres who excel.
GRAPHENE AS AN ANTIOXIDANT AND ANTIOZONANT IN TIRE SIDEWALL COMPOUNDS
Authors: Paschall Doug , Halasa Adel , Rodgers Brendan 
Published: July 2024

ABSTRACT
Tire sidewalls have an important function in achieving optimized tire performance. The sidewall compound must show good abrasion resistance, aging resistance, and tear strength; low hysteresis and minimal contribution to whole tire rolling resistance; and good adhesion to adjacent components in the tire. In addition, in both the original equipment market and the premium performance market, appearance is of considerable importance. The current system of waxes, antioxidants, and phenyl diamine antiozonants is very effective in meeting the need of the tire end user. However, recent concerns centered on the environmental impact of N′-phenyl-p-phenylenediamine, specifically N-(1,3-dimetylbutyl)-N′-phenyl-p-phenylenediamine, and staining and discoloration of the tire sidewall surface raise issues that should be addressed. Specialized grades of graphene can offer a mechanism by which tire appearance and environmental concerns can be overcome. Pristine graphene can improve compound resistance of ozonolysis and oxidation by replacing the current antiozonants and antioxidants used in tire compounds; improve tire sidewall appearance; and improve tire sidewall resistance to scuffing, abrasion, and tearing.