bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
Authors: Dellino Miriam , D’Amato Antonio , Battista Gaia , Cormio Gennaro , Vimercati Antonella , Loizzi Vera , Laganà Antonio Simone , Damiani Gianluca Raffaello , Favilli Alessandro , Gerli Sandro , La Forgia Daniele , Daniele Antonella , Agrifoglio Vittorio , Cicinelli Ettore , Vitagliano Amerigo , Etrusco Andrea 
Published: August 2024

Abstract

Objective
To evaluate the reproductive outcomes of patients bearing BRCA-1 and BRCA-2 mutations.

Methods
In this retrospective observational cohort study, we assessed data from BRCA-1 and BRCA-2 carriers, analyzing demographics, oncological history, and reproductive outcomes. Statistical analysis compared BRCA-1 and BRCA-2 carriers. A thorough review of the literature was carried out.

Results
Fifty-eight patients were included. BRCA-1 and BRCA-2 mutations were equally distributed. Eighty-nine pregnancies occurred in our series, hesitated in 73 live births and 19 miscarriages. Mean age at first and last pregnancy was 27.8 ± 4.8 and 31.6 ± 4.8 years old. Thirty-nine patients have had at least one live birth (67.2%). Mean number of live births was 1.9 ± 0.6. Live birth rate (LBR) was 81.1% and miscarriage rate was 32.8%. Spontaneous fertility was unaltered, as evidenced by high LBR. Subgroup analysis revealed no significant differences between BRCA-1 and BRCA-2 carriers.

Conclusions
Our results shows that spontaneous reproductive outcomes in BRCA-mutated patients are reassuring. Despite evidence indicating a decrease in ovarian reserve among BRCA patients, this factor seems to not impact spontaneous fertility negatively. Further research is needed, and individuals with BRCA mutations should consider early family planning and fertility preservation in case of partner absence.
Your favourite authors favourite authors: a bibliometric social network analysis of hip-hop education literature
Authors: Cason Marti , Young Jamaal , Young Jemimah 
Published: August 2024

Abstract
Hip-hop culture can be found globally, and hip-hop educators can be found in these same spaces. Therefore, hip-hop has been in classrooms and has been increasingly popular in a multitude of disciplines, including but not limited to health sciences, sociology, and education. Given the vast reach of hip-hop education research, a logical next step is to characterize the impact of hip-hop education scholarship using bibliometrics. We examined hip-hop education through the lens of bibliometrics and social network analysis (SNA). A pool of 371 studies was identified for citation analysis. The findings of this study contribute to the literature by characterizing the development of hip-hop education research. Specifically, we contribute to the field by: (1) identifying key scholarly contributions in hip-hop education and the linkages among them, (2) tracing the evolution of the field over time, (3) analyzing the impact of hip-hop on the field of education, and (4) exploring the cross-disciplinary role of hip-hop education research. Implications are provided for future research and praxis to support learners in urban spaces.
Nancy in Jerusalem: Soundscapes of a City
Authors: Belford Liora 
Published: August 2024

Abstract
Attuned to sonic, aesthetic, and sensory modes of experience, and directed particularly to explore the implications of sound as it informs political thought and actions, in 2021, I began investigating Jerusalem’s soundscape. Following Jean-Luc Nancy’s argument that our perception is impacted by the subjectivity of listening, I invited a group of Palestinian and Israeli artists to work with me on this project, hoping to capture the multiple soundscapes this city offers to its residents, visitors, and passers-by. In this essay, I examine two of the group's projects: “Listening Walks in Jerusalem,” an online sonic archive open for anyone to listen to and download; and “Scores for Social Acoustics in Jerusalem,” an anthology of suggested listening paths in the city. I suggest that these artistic acts succeeded in capturing a range of sonic experiences of Jerusalem and may even have gone beyond Nancy’s words to provide tangible methods for listening to a sound event and hearing it (almost) the same.
Exploring the photocatalytic efficacy of core–shell CeO2/TiO2 nanocomposite synthesized via solution combustion synthesis
Authors: Muhammad Fathima Khyrun , Arulanandam Jegatha Christy 
Published: August 2024

Abstract
This study investigates the photocatalytic efficacy of core–shell CeO2/TiO2 nanocomposite (CT-NC) synthesized via solution combustion synthesis. Various characterization techniques including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), UV–visible spectroscopy (UV), photoluminescence spectroscopy (PL), Raman spectroscopy, field emission scanning electron microscopy (FESEM) along with energy-dispersive spectroscopy (EDS) analysis and high-resolution transmission electron microscopy with selected area electron diffraction (HRTEM-SAED) were employed to analyze the nanomaterials. XRD pattern confirmed the realization of cubic and tetragonal phases of CeO2 and TiO2. The vibrational modes observed below 800 cm−1 confirmed the metal-oxygen bonds of the synthesized samples. The energy bandgap (Eg) of CT-NC, as estimated from UV–vis spectra, reduced to 2.28 eV, resulting in a significant enhancement of the photocatalytic activity. The various emission peaks in the visible region due to the oxygen vacancies facilitated the generation of Reactive Oxygen Species (ROS). EDS analysis confirmed the presence of elements and the purity of the samples. Furthermore, CT-NC demonstrated remarkable dye degradation efficiency, achieving a maximum efficiency of 98.15 % under visible light irradiation for 120 min. This enhanced activity is attributed to the Advanced Oxidation Process (AOPs). Overall, the results highlight the potential of CT-NC as an efficient photocatalyst for environmental remediation.
Disentangling temporal and rate codes in primate somatosensory cortex
Authors: Callier Thierri , Gitchell Thomas , Harvey Michael A. , Bensmaia Sliman J. 
Published: August 2024

Millisecond-scale temporal spiking patterns encode sensory information in the periphery, but their role in cortex remains controversial. The sense of touch provides a window into temporal coding because tactile neurons often exhibit precise, repeatable, and informative temporal spiking patterns. In somatosensory cortex (S1), responses to skin vibrations exhibit phase-locking that faithfully carries information about vibratory frequency. However, the respective roles of spike timing and rate in frequency coding are confounded because vibratory frequency shapes both the timing and rates of responses. To disentangle the contributions of these two neural features, we measured S1 responses as male Rhesus macaques performed frequency discrimination tasks in which differences in frequency were accompanied by orthogonal variations in amplitude. We assessed the degree to which the strength and timing of responses could account for animal performance. First, we showed that animals can discriminate frequency, but their performance is biased by amplitude variations. Second, rate-based representations of frequency are susceptible to changes in amplitude, but in ways that are highly inconsistent with the animals' behavioral biases, calling into question a rate-based neural code for frequency. In contrast, timing-based representations are highly informative about frequency but impervious to changes in amplitude, which is also inconsistent with the animals' behavior. We account for the animals' behavior with a model wherein frequency coding relies on a temporal code, but frequency judgments are biased by perceived magnitude. We conclude that information about vibratory frequency is not encoded in S1 firing rates but primarily in temporal patterning on millisecond time scales.Significance statementWhile neurons in the cerebral cortex are known to produce temporally patterned responses with single-digit-millisecond precision, whether this patterning contributes to sensory coding remains controversial. The alternative hypothesis is that the critical feature of neuronal responses is the firing rate, and the distribution of the spikes in time only matters at slower time scales. To disentangle these two putative neural codes, we trained animals to discriminate the frequency of skin vibrations while recording from S1. Unlike previous studies addressing a similar question, we randomly varied stimulus amplitude over a wide range. While results from those studies were consistent with either hypothesis, we show that only a timing-based representation of frequency can account for animal performance on this frequency discrimination task.
Strategi Hubungan Masyarakat dalam Meningkatkan Citra SMK Hidayah Kota Semarang
Authors: Nadia Anggraeni Nadia Anggraeni , Pramusinto Hengky 
Published: August 2024

This study aims to investigate public relations strategies, obstacles faced, and steps taken by public relations to improve the image of prospective students SMK Hidayah Semarang City. This type of research uses qualitative descriptive analysis, data collection techniques for this research use observation, interviews and documentation methods. The research results show that the Public Relations strategy at SMK Hidayah Semarang consists of publications, events, news, community involvement, inform or image, lobbying, and negotiations, social responsibility; Obstacles that occur in carrying out the public relations strategy of SMK Hidayah Semarang, namely the lack of human resources to assist the performance of public relations in schools, and the existence of zoning system regulations; Efforts made by Public Relations to overcome obstacles are by involving all school staff to help with Public Relations activities, either collaborating with other Head of Student Affairs, or requiring teachers to create WhatsApp stories as a form of promotion, and put up banners, distribute brochures, and publicize via the SMK website guidance. This research provides information as a form of evaluation for public relations in schools regarding public relations marketing management
Anatomical Ablation of the Atrioventricular Node
Authors: Katritsis Demosthenes G , Siontis Konstantinos C , Agarwal Sharad , Stavrakis Stavros , Giazitzoglou Eleftherios , Amin Hina , Marine Joseph E , Tretter Justin T , Sanchez-Quintana Damian , Anderson Robert H , Calkins Hugh 
Published: August 2024

Background: Atrioventricular (AV) conduction ablation has been achieved by targeting the area of penetration of the conduction axis as defined by recording a His bundle potential. Ablation of the His bundle may reduce the possibility of a robust junctional escape rhythm. It was hypothesised that specific AV nodal ablation is feasible and safe. Methods: The anatomical position of the AV node in relation to the site of penetration of the conduction axis was identified as described in dissections and histological sections of human hearts. Radiofrequency (RF) ablation was accomplished based on the anatomical criteria. Results: Specific anatomical ablation of the AV node was attempted in 72 patients. Successful AV nodal ablation was accomplished in 63 patients (87.5%), following 60 minutes (IQR 50–70 minutes) of procedure time, 3.4 minutes (IQR 2.4–5.5 minutes) of fluoroscopy time, and delivery of 4 (IQR 3–6) RF lesions. Αn escape rhythm was present in 45 patients (71%), and the QRS complex was similar to that before ablation in all 45 patients. Atropine was administered in six patients after the 10-min waiting period and did not result in restoration of conduction. In nine patients, AV conduction could not be interrupted, and AV block was achieved with ablation of the His after delivery of 12 (IQR 8–15) RF lesions. No cases of sudden death were encountered, and all patients had persistent AV block during a median 10.5 months (IQR 5–14 months) of follow-up. Conclusion: Anatomical ablation of the AV node is feasible and safe, and results in an escape rhythm similar to that before ablation.
Biochar-Bio-Cu composite superhydrophobic membrane for efficient oil-water separation
Authors: Beagan A. , Yang Z. , Mohamed M. E. 
Published: August 2024

This manuscript presents the development of a superhydrophobic textile fabric (SF) for effective oil–water (O/W) separation. A biochar was synthesized by pyrolysis of banana leaves. The bio-Cu nanoparticles (bio-Cu NPs) were synthesized from grape seed extract. The biochar and bio-Cu NPs were used to enhance the surface roughness of the textile fabric. The low-cost, eco-friendly stearic acid was used as a low surface energy material. The SF achieves a water sliding angle of 1 degree and apparent contact angle of 159 degrees, indicating its superhydrophobic nature. The absorption capacity toward silicone oil (SO), toluene, and crude oil (CO) is measured at 102.2 g/g, 98.5 g/g, and 91.0 g/g, respectively, with minimal decrease after ten usage cycles. The SF exhibits outstanding O/W separation efficiencies for CO (99.6%), toluene (98.9%), and SO (97.5%) over ten cycles. Mechanical stability assessments reveal superhydrophobicity retention till a length of abrasion equal to 650 mm. Chemical stability investigations demonstrate SF’s resilience across a pH range of 1–13 over 2 h of immersion. Furthermore, the SF shows a good flux rate toward the oils used. These findings establish a promising advancement in environmental remediation and O/W separation.
Lenvatinib and pembrolizumab combination in metastatic renal cell carcinoma: experience of the Republic of Bashkortostan
Authors: Menshikov K. V. , Lipatov D. O. , Nasretdinov A. F. , Musin Sh. I. , Sultanbaeva N. I. , Menshikova I. A. , Sultanbaev A. V. , Izmaylov A. A. , Galimov Sh. N. , Rezyapova A. Sh. 
Published: August 2024

Background. Lenvatinib and pembrolizumab combination showed statistically significant and clinically important improvements for progression-free survival (PFS), overall survival (OS), and objective response rate compared to sunitinib.Aim. To evaluate the effectiveness and safety of lenvatinib and pembrolizumab combination in patients with metastatic renal cell carcinoma in clinical practice at the Republican Clinical Oncological Dispensary (Ufa).Materials and methods. The study included 24 patients (20 men and 4 women) with clear cell renal cell carcinoma. Patients with ECOG (Eastern Cooperative Oncology Group) score 0–3, any Karnofsky scale status, and no detection of PD-L1 expression in the tumor were included. Follow-up period was 24 months.Results. Objective response rate was 68 % which is consistent with the CLEAR trial value of 72 %. Six-month PFS was 82 %, 12-month PFS was 70 %; 6-month OS was 91.2 %, 12-month OS was 83.4 %. Median PFS and OS were not reached. There were no new safety signals for the lenvatinib and pembrolizumab combination. Grade III adverse events were arterial hypertension and hepatotoxicity.Conclusion. In real clinical practice, lenvatinib and pembrolizumab combination showed results consistent with the data of the basic clinical trial despite short follow-up and expanded inclusion criteria.
Artificial intelligence in diagnosis of prostate cancer using magnetic resonance imaging. New approach
Authors: Aboyan I. A. , Redkin V. A. , Nazaruk M. G. , Polyakov A. S. , Pakus S. M. , Lemeshko S. I. , Hasigov А. V. 
Published: August 2024

Aim. To improve the diagnosis of prostate cancer by training a neural network to identify malignant tumor lesions using the results of magnetic resonance imaging (MRI) studies with the same or greater accuracy than an experienced radiologist, using as the truth histological mapping of slides performed by a morphologist.Materials and methods. The work was performed at the “Zdorovie” Clinical and Diagnostic Center in Rostov-on-Don. Patients selected for the study underwent MRI in the Philips Ingenia 3.0T machine according to the prostate multiparametric MRI protocol, which complies with the requirements of PI-RADS v.2.1. The obtained data was used to train a convolutional neural network based on the U-Net architecture. The correct map of the actual locations of prostate cancer lesions was obtained using the “Morphologist’s digital mapping tool” software.Results. The research part of the work consisted of following stages:development of the “Morphologist’s digital mapping tool” software for virtualization of lesions;analysis of MRI data archive, retrospective selection of patients;mapping of data by a morphologist to identify lesions in the prostate with layer-by-layer transfer of visualized lesions in the histological preparation to the image of the prostate gland in the “Morphologist’s digital mapping tool”, as well as training of the neural network to identify the presence of a malignant neoplasm in the prostate, location of the lesion(s), clinically significant disease;data validationFor a certain amount of input data and high-quality mapping of this data, the neural network is capable of detecting prostate cancer lesions with the same accuracy as an experienced radiologist. Validation showed that the neural network correctly localized prostate cancer in 78 % of cases, while the radiologist did so in 55 % of cases. Comparative analysis also revealed the ability of the neural network to detect prostate cancer in areas of the prostate where the radiologist could not recognize any visual patterns indicating the presence of prostate cancer.Conclusion. Training a neural network without the participation of a radiologist is a fundamentally new approach that allows to sidestep the experience and qualifications of a radiologist in interpreting the obtained multiparametric MRI images.
Cultural determinants in anemia prevention and management: Insights from women and caregivers
Authors: Garg Ram Kumar , Bala Jyoti , Garg Prabha , Subashini S. P  , Jasline M Jasline M , Vedamurthy R  , Mudhol Basavaraj , Mol Viji 
Published: August 2024

Anemia poses a significant global health challenge, particularly impacting women and caregivers across diverse cultural settings. This abstract delves into the profound influence of cultural beliefs and practices on anemia prevention and management behaviors, drawing insights from the experiences of women and caregivers.Cultural norms shape individuals' perceptions of anemia, influencing attitudes towards preventive measures and treatment adherence. These beliefs, deeply entrenched within specific cultural contexts, significantly affect health-seeking behaviors and intervention outcomes.Women, often primary caregivers and disproportionately affected by anemia, navigate cultural expectations that shape their dietary habits, healthcare-seeking behaviors, and attitudes towards medical interventions. Additionally, gendered cultural roles intersect with anemia prevention efforts, impacting susceptibility and intervention efficacy targeting women's health.Caregivers, crucial in supporting individuals affected by anemia, are also influenced by cultural beliefs and practices. Understanding the cultural context surrounding caregiving roles is essential for devising comprehensive anemia management strategies that engage caregivers effectively and optimize patient outcomes.Acknowledging the diversity of cultural beliefs surrounding anemia is critical for developing tailored prevention and management approaches. Culturally competent interventions respect and leverage cultural norms to enhance their relevance and effectiveness within specific cultural contexts.By integrating insights from women and caregivers, this abstract emphasizes the importance of cultural sensitivity in addressing anemia. Embracing cultural diversity and understanding its influence on anemia-related behaviors are essential steps towards improving health outcomes and reducing the burden of anemia globally.
Optimizing obesity management for women in an Indian obstetrics and gynecology setting: A consensus approach by the Indian Society of Assisted Reproduction (ISAR)
Authors: Palshetkar Nandita , Pai Hrishikesh , Patel Madhuri , Patki Ameet , Tandulwadkar Sunita , Purandare Ameya , Tambe Pratik , Palshetkar Rohan , Pai Murlidhar V , Banerjee Dibyendu , Singh Neeta , Kumar Aswath , Thakkar Piya Ballani , Kapoor Nitin 
Published: August 2024

Obesity has emerged as a pressing global and national concern, with a disproportionate impact on women's health. It is associated with a myriad of adverse outcomes including polycystic ovarian syndrome, infertility, gestational diabetes mellitus, miscarriages, birth defects, and so on. Despite its prevalence in clinical settings, the effective management of obesity remains a formidable challenge, emphasizing the urgent need for enhanced interventions tailored to Indian women. A set of 14 pivotal clinical inquiries was devised by conducting a literature search. The quality of evidence and consensus statements was evaluated with the help of the GRADE approach. The objective was to gather consensus from a pool of experts regarding the statements, utilizing the Delphi methodology. This consensus paper is an initiation by the Indian Society of Assisted Reproduction (ISAR), and it aims to provide evidence-based and pragmatic clinical insights to optimize obesity management, and an easy-to-use algorithm specifically tailored for Obstetricians and Gynecologists (O&G) in India. The proposed algorithm could help individualize obesity management, ultimately improving health outcomes and quality of life for Indian women seeking gynecological care.
Treatment of anaemia in pregnancy with oral iron, folic acid or iron, folic acid and vitamin B12 supplementation: A hospital-based open randomized study
Authors: Ramchandran Prema , Sharma Anshu , Ravinder P , Nair K Madhavan , Kalaivani K 
Published: August 2024

: National iron plus initiative recommended that anaemic pregnant women should be treated with 200 mg of elemental iron and 1 mg folic acid. An increase in vitamin B12 deficiency has been reported in last two decades. An open randomised study was taken up in urban antenatal clinics to assess the impact of addition of vitamin B12 to the iron and folic acid supplementation.: Anaemic pregnant women willing to participate in the study were randomised into Group 1 (240 iron mg and 5 mg folic acid) or Group 2 (240 mg iron, 1.5 mg of folic acid and 15 µg vitamin B12); the impact of supplementation on Hb, ferritin, folic acid and vitamin B12 was assessed.: In both groups mean Hb improved by 1g/dL at 8 weeks and by 1.5g/dL by 38 weeks of pregnancy; at 38 weeks only 30% were anaemic. Mean ferritin and folic acid levels improved in both groups. There was a fall in the mean vitamin B12 levels in the group which received 5 mg of folic acid.: With assured supply and supportive supervision, the supplementation achieved substantial reduction in anaemia in both groups. Supplementation with folic acid 5 mg should not be done because it causes a fall in vitamin B12 levels. The reason why addition of vitamin B12 to iron folic acid supplementation did not result in improvement in mean Hb, or vitamin B12 levels has to be investigated.