bluuebunny/crossref_metadata_2025_split huggingface dataset:
TWO SISTERS WITH GUTTATE PSORIASIS RESPONSIVE TO TONSILLECTOMY
Authors: Saita Buzou , Ishii Yoshimitsu , Ogata Katsumi , Kikuchi Ichiro , Inoue Shohei , Naritomi Kenji 
Published: April 2015

ABSTRACTAn 11‐year‐old girl and her 7‐year‐old sister, both with guttate psoriasis, both showed chronic tonsillitis and proteinuria. The ASO titer of the elder sister was 480 units and that of the younger sister 320 units. Tonsillectomies were performed on both sisters because they developed guttate psoriasis after colds with severe sore throats and proteinuria. Skin lesions improved markedly and proteinuria disappeared, but ASO titers did not change significantly. HLA studies were made of the sisters and their parents; A1 and B37 were confirmed in both sisters and their mother.
LYMPHOCUTANEOUS SPOROTRICHOSIS CAUSED BY ACCIDENTAL INOCULATION
Authors: Ishizaki Hiroshi , Ikeda Masayasu , Kurata Yukio 
Published: April 2015

ABSTRACTAn inoculation accident resulting in the lymphocutaneous form of sporotrichosis in a 27‐year‐old dermatologist is described. The initial symptom was a nodule which appeared 12 days after inoculation at the inoculation site on the right third finger. Subsequent lesions appeared like stepping stones by way of the lymphatics on the dorsa of the hand and forearms, followed finally by involvement of the right supraclavicular lymph nodes. The patient was successfully treated with potassium iodide.
A STUDY OF THE BUFFY COAT LEUCOCYTE AGGREGATION TEST
Authors: Kim Won Suk , Cinn Yong Woo , Lee Yoo Shin , Chang Woo Hyun , Kim Ik Sang 
Published: April 2015

ABSTRACTThe validity of the buffy coat leucocyte aggregation (BCLA) test was studied. We found that the test was highly specific and reproducible. At the same time, the degree of aggregation in the presence of tuberculin Purified Protein Derivative (PPD) correlated well with the diameter of the skin test response to that antigen. The leucocytes in the buffy coat of penicillin sensitive subjects were not aggregated with the addition of sodium penicillin antigen, indicating that the test was unable to differentiate penicillin sensitive from penicillin insensitive subjects. The methods of macroscopic and microscopic quantitation of aggregates were evaluated. We preferred to use the macroscopic method, as the result of macroscopic readings correlated well with that of microscopic readings in our test system.
TRAUMATIC ANSERINE FOLLICULOSIS
Authors: Padilha‐Gonçalves Antar 
Published: April 2015

ABSTRACTProlonged friction and pressure on limited areas of the skin with other naked skin parts of the patient, occurring mostly from positional attitudes, as, for instance, resting the chin on the hands or knees while watching television, may cause peculiar cutaneous lesions. The occurrence of some cases of this dermatologic picture has led to the description of a dermatosis heretofore not reported that has been denominated traumatic anserine folliculosis (folliculosis anserina traumatica) — stressing the traumatic etiology, the goose skin (anserine) appearance and the follicular clinical aspect that may resemble keratosis follicularis.Up to now, 11 cases have been observed, occurring on the chin of 9 patients (also in both jaws of 1), on the right jaw of 1 and the neck of 1. The problem occurs mostly in children or young people; apparently delicate skin is an important factor. About 63.6% of the patients have an atopic background: On the points of friction and pressure ill limited patches of grouped, very small conical elevations are seen, either the same color as the patient's skin, or slightly hyperpigmented, with or without erythema and showing a goose skin (anserine) appearance. Tactilely, it resembles sand paper.The histopathology is characterized by varied but not intensive changes. In tissue sections may be seen: rudimentary follicles, follicular hyperkeratosis, focal increase of stratum lucidum, slight hypergranulosis, vasodilatation especially nearby the follicles, and small perivascular infiltration, predominantly lymphocytic.
URTICARIA PIGMENTOSA IN TWO PAIRS OF MONOZYGOTIC TWINS
Authors: Kuan Y.Z. 
Published: April 2015

ABSTRACTUrticaria pigmentosa occurred in both members of two pairs of twins. Identical blood typings, HLA histocompatibility and appearance strongly indicate that each pair of twins is monozygotic.Except for cutaneous lesions, there were no clinical or roentgenologic evidences of systemic mastocytosis. But latent diabetes mellitus was found in one member.Literature reporting monozygotic twins with urticaria pigmentosa will be discussed in this paper.
ADENOSINE DIPHOSPHATE RIBOSE PYROPHOSPHOHYDROLASE IN HUMAN SKIN
Authors: Kim Young Pio , Kahng Johng Bong , Choi Jum Yul 
Published: April 2015

ABSTRACTAdenosine diphosphate ribose (ADPR) pyrophosphohydrolase (ADPR‐PPase), which catalyzes the hydrolysis of ADPR to yield adenosine monophosphate (AMP) and ribose‐5′‐phosphate, was assayed in human penile foreskin. Since ADPR is formed from nicotinamide adenine dinucleotide (NAD) by NAD glycohydrolase (NADase), NADase was also assayed in human skin.The skin tissue obtained by circumcision was separated into three layers; epidermis of the outer prepuce, epidermis of the inner prepuce, and dermis. ADPR‐PPase was found to be present in all of the three layers with nearly equal activity. NADase was also present in the epidermis of both the outer and inner prepuce, being about two times higher in the latter, but no activity was found in the dermis. When expressed in units of the same specific activity; i.e., μmoles product formed per hour per mg protein, the ADPR‐PPase of human skin had two to five times greater activity than did NADase. The ADPR‐PPase of human skin was activated by Mg+2, but inhibited by AMP and ATP.These results suggest that the breakdown of NAD occurs in human skin via ADPR to AMP and ribose‐5′‐phosphate by sequential action of NADase and ADPR‐PPase.
SUBCUTANEOUS FAT NECROSIS ASSOCIATED WITH PANCREATITIS AND GASTRIC CARCINOMA
Authors: Ishizaki Hiroshi , Eguchi Kazuo , Kaseda Hidenori , Kaihara Hiroaki , Konishi Koji , Himi Akiko 
Published: April 2015

ABSTRACTSubcutaneous fat necrosis associated with acute pancreatitis in a 54‐year‐old man was reported. The acute pancreatitis was proved histologically after gastrectomy for coincident early gastric carcinoma. The patient was successfully treated with prednisolone and his skin lesions subsided within a month.
DERMATOLOGICAL SURVEY OF ONCHOCERCIASIS IN GUATEMALA
Authors: Nonaka Shigeo , Hashiguchi Yoshihisa , Kawabata Masato , Aoki Yoshiki , Tada Isao , Marroquin Horacio Figueroa , Flores Guillermo Zea 
Published: April 2015

ABSTRACTA comprehensive survey of onchocerciasis was performed on 1259 inhabitants in San Vicente Pacaya and the surrounding area. The total number of inhabitants examined was 1259, 763 males and 496 females. An examination of microfilarial density was carried out by the skin snip method. There were 610 microfilarial positives (50.4%) out of 1211 persons, 448 males (60.9%), and 162 females (34.1%). Nodules were examined by palpation, and there were 404 (32.8%) positives for nodule out of 1232 persons, 299 males (40.3%), and 105 females (21.4%). Eczematous dermatitis was seen in 149 persons, the generalized type in 13, and other types in 136. Depigmentation on the lower extremities was seen in 290 persons, the severity was graded from 0 to 4, and grade 1 depigmentation was seen in 91; grade 2, in 143; grade 3, in 52 and grade 4 in 4 persons out of 1159 individuals examined. The positives for lymphadenopathy (above grade 2) were 464 (41.2%) out of 1127 individuals. Itching was seen in 129 (18.3%) of 705 individuals examined by the inquiry card method.The correlation between skin changes and onchocerciasis was also analyzed. Those individuals who were microfilarial positive in the skin snip and eyes, and who had palpable nodules were defined as being onchocerciasis patients. There was a high frequency of eczematous dermatitis, depigmentation on the lower extremities and lymphadenopathy in the onchocerciasis infected group, compared with the non‐infected group, but there was no difference in the rate of itching between them. Hanging groin, elephantiasis and “erisipela de la costa” were not seen in this endemic area, and the degree of skin changes was slight, compared with that reported in Africa thus far.
PSORIASIS OCCURING IN YOUNG MONOZYGOTIC TWINS
Authors: Mori Norio , Yoshikawa Kunihiko , Ohno Morihide 
Published: April 2015

ABSTRACTPsoriasis occuring in monozygotic twins is reported. Although these patients had a different living environment since birth the similarity in psoriatic pattern and its time of onset suggested the strong influence of genetic factors. However the major histocompatibility antigens A2, A11, Bw16, found in these patients were not those, which have been reported to be significantly increased among Japanese psoriatics.
CORRELATION BETWEEN COMPLEMENT‐FIXING PEMPHIGOID ANTIBODY TITRES AND DISEASE ACTIVITY
Authors: Kurihara Seiichi , Nishikawa Takeji , Sugawara Makoto , Hatano Hitoshi 
Published: April 2015

ABSTRACTA positive correlation between complement‐fixing pemphigoid antibody titre and disease activity was observed in 4 of 8 patients with bullous pemphigoid using complement immunofluorescence. The fact that this correlation cannot always be demonstrated seems to contradict the active role of complement‐fixing pemphigoid antibodies in the pathogenesis of bulla formation. The similarity of bullous pemphigoid and herpes gestationis is discussed.
CYCLIC AMP LEVEL IN DIFFERENT LAYERS OF PSORIATIC EPIDERMIS
Authors: Aoyagi Takashi , Kamigaki Katsuko , Miura Yusho 
Published: April 2015

ABSTRACTIn the present study we have determined intracellular levels of cyclic AMP in psoriatic epidermis, which had been microdissected. Involved epidermis had relatively higher cyclic‐AMP levels on a tissue weight basis than did uninvolved epidermis, but no significant differences on a DNA basis were obtained. Further microdissection of psoriatic epidermis made it possible to determine cyclic AMP levels in the upper and lower half of the epidermis, respectively. The results clearly demonstrated that the upper epidermis had significantly higher levels of cyclic AMP than the lower epidermis on a DNA basis in individual cases, but no differences between the upper and lower epidermis of involved psoriatic epidermis were obtained on a dry weight basis. It is suggested that the lower levels of cyclic AMP in the lower half of the epidermis may be due to increased activity of cyclic AMP phosphodiesterase as described by Iizuka et al., or to retarded responsiveness of adenylate cyclase to endogenous stimulators in the lower half of the epidermis where the cell surface could be more easily affected by dermal components than the upper half of the epidermis.
PLANTAR MALIGNANT MELANOMA
Authors: Hosokawa Michiko , Kato Taizo , Seiji Makoto , Abe Rikiya 
Published: April 2015

ABSTRACTAmong 51 cases of malignant melanoma seen at the Department of Dermatology, Tohoku University School of Medicine, from 1966 to 1978, 16 cases had had the primary lesion on the sole. The average age of these 16 cases was 63 and the sex ratio (M:F) was 11:5. The common sites of involvement on the sole were the heel (in 9 cases) and the toes and metatarsal region (in 5 cases). In 14 cases the lesions arose on the right sole; furthermore, 6 cases had had histories of trauma before or after the development of tumor and 7 cases had received insufficient excisions of their lesions, all of which showed a recurrence and/or lymph node metastasis within a year. These data suggest that traumatic stimulation may have some effect up on the pathogenesis of plantar melanoma.The clinicopathological features of plantar malignant melanoma in Japan are also described.
A SEMIQUANTITATIVE ANALYSIS OF SKIN SENSITIVITY CHANGES IN HERPES ZOSTER
Authors: Matsubara Motoo , Kagami Kiyoshi , Maeda Motoaki , Yasuno Hirokazu , Uchida Takashi , Suzuki Naoto 
Published: April 2015

ABSTRACTWe have investigated changes in skin sensation in patients affected with Herpes zoster, by comparing the threshold of electric stimulation pain at the lesion site with that at the symmetrical healthy site. The threshold at the lesion was lower than that at the healthy site and had a tendency to recover to normal day by day. When continuous and spontaneous pain were combined, the threshold at the lesion was rather higher, probably due to a kind of masking. The change in threshold during the recovery process is not correlated with the seriousness of this disease.
ELEVATED LEVELS OF CHEMOTAXIS INHIBITORY ACTIVITY IN SERA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Hasegawa Shoji , Baba Toru , Koitabashi Yasushi , Shimizux Yayoi , Sonozaki Hidekichi , Hori Yoshiaki , Nishiyama Shigeo 
Published: April 2015

ABSTRACTAn inhibitory activity against neutrophil chemotactic factors was found in normal human serum. Elevated levels of this chemotaxis inhibitory activity were demonstrated in sera of patients with systemic lupus erythematosus (SLE).The physico‐chemical characteristics of this chemotaxis inhibitory substance(s) in SLE serum were almost identical to those of the inhibitory substance(s) in normal human serum; both the inhibitory substances were heat labile, soluble in 45% saturated ammonium sulphate, worked directly on chemotactic factor and affected various chemotactic factors. A study using Sephadex G‐ 100 chromatography showed that the molecular sizes of both inhibitory substances were almost identical.No correlation was found between the levels of the chemotaxis inhibitory activity in SLE sera and other clinical parameters including erythrocyte sedimentation rate, and serum concentration of either the third component of complement (C3) or the fourth component of complement (C4).Specimens from patients with the following diseases failed to demonstrate elevated levels of chemotaxis inhibitory activities; rheumatoid arthritis, urticaria, psoriasis vulgaris, atopic dermatitis and discoid lupus erythematosus (DLE).
CLINICAL AND PHOTOBIOLOGICAL DIFFERENCES BETWEEN DYSCHROMATOSIS SYMMETRICA HEREDITARIA AND XERODERMA PIGMENTOSUM
Authors: Satoh Yoshiaki , Yoshida Masami 
Published: April 2015

ABSTRACTThe data from various tests including phototests and DNA repair capacity, and clinical observations on three cases of infantile dyschromatosis symmetrica hereditaria (Dsh) were studied in comparison with those from 18 cases of the so‐called defective type of xeroderma pigmentosum (XP) in the same age group. There were no abnormalities common to the both diseases, except for pigment anomaly.In Dsh, in contrast with XP, cutaneous lesions due to photosensitivity were not observed. Furthermore, ocular symptoms, neurological abnormalities and retardation or underdevelopment of somatic and mental growth were not seen, nor was there any abnormality in repair capacity as measured by ultraviolet light‐induced unscheduled DNA synthesis. These findings led to the conclusion that Dsh and XP are two different disorders etiologically.
ELECTRON MICROSCOPIC STUDIES OF POROKERATOSIS MIBELLI
Authors: Sato Akihiko , Masu Shinichi , Seiji Makoto 
Published: April 2015

ABSTRACTElectron microscopic investigations of lesions from 5 cases of porokeratosis Mibelli clarified that the cornoid lamella was composed of two types of abnormal horny cells, the precursors of which were detected as dyskeratotic cells and autolytic cells in the epidermis directly beneath the cornoid lamella. Therefore, it was concluded that the cornoid lamella might be caused by a disturbance of keratinization of genetically fragile keratinocytes. On the other hand, some sort of repair mechanism might be present in the epidermis of the lesion by which degenerated epidermal cells (Civatte bodies) are transferred from the epidermis into the cutis. In the cutis of the lesion, Civatte bodies were found in one case and amyloid in three cases. However, neither the coexistence of both nor an intermediate form was detected. These findings strongly suggest a possible conversion of Civatte bodies into amyloid.
FREEZE‐FRACTURE STUDY OF THE OCCURRENCE OF PLASMA MEMBRANE DIFFERENTIATIONS IN HUMAN BASAL CELL CARCINOMA
Authors: Kitajima Yasuo , Mori Shunji 
Published: April 2015

ABSTRACTFreeze‐fracture electron microscope technique was used to study the plasma membrane ultrastructure of basal cell carcinoma (BCC) cells biopsied from two patients. Freeze‐fracture replicas of the plasma membrane of BCC cells indicated the presence of gap junctions, tight junctions and desmosomes. Tight junctions were found on almost all fracture faces of BCC cell plasma membranes, while they were seldom found in the normal keratinocytes or basal cells. These tight junctions appeared as an incomplete network of anastomosing strands with many free‐ending spurs. The frequency of gap junctions seemed to increase in number but decrease in size as compared with normal keratinocytes. Many of the gap junctions were associated with tight junctions. Desmosomes varied in size from 0.1 to 1 µm and were found rather frequently. The results of this study indicated that these junctional complexes were very well developed and that these well differentiated junctions may explain the BCC cell's disinclination to metastasize.
BUSULFAN HYPERPIGMENTATION: LIGHT AND ELECTRON MICROSCOPIC STUDIES
Authors: Adam B.A. , Ismail Rokiah , Sivanesan S. 
Published: April 2015

ABSTRACTSkin with busulfan hyperpigmentation was studied using light and electron microscopy. There were both toxic effects on the melanocytes and stimulatory effects on the production of melanin. The mitochondria appeared damaged, and reduced in number. Cytoplasmic vacuoles, myelin figures and conglomerate masses of melanosomes were present. The melanosomes were normal in size but appeared increased. 'Ghost melanocytes' were found in the dermis. The basal lamina was damaged with evidence of duplication. Incontinence of melanin was seen. This hyperpigmentation may be similar to that in fixed drug eruption.
ULTRASTRUCTURAL OBSERVATIONS OF FUNGAL ELEMENTS IN TRICHOPHYTON RUBRUM GRANULOMA
Authors: Otsuka Fujio , Mizoguchi Masako , Takizawa Kiyohiro 
Published: April 2015

ABSTRACTWe observed fungal elements in Trichophyton rubrum granuloma ultrastructurally. Three types of fungal elements could be distinguished in relation to the phagocytes, namely (1) fungal elements existing freely in the exudate, (2) fungal elements attached to the phagocytes or just ingested into the phagocytes, (3) fungal elements digested in the phagocytes.Fine structures of fungal elements with high biological activity which were not under the influence of digestion by the phagocytes were fundamentally almost as same as those of cultural fungal elements in other reports. In some fungal elements, an exceptional mitochondrion 5.4 μ in length could be recognized.In the process of digestion and denaturation of fungal elements, several ultrastructural findings were noted as follows; (1) the plasma membrane and intracellular organelles became obscure or diminished, (2) an increase in electron density, lamellation and swelling of the cell wall were observed.
EFFECT OF LOCAL HYPERTHERMIA ON TWO CASES OF PSORIASIS VULGARIS
Authors: Urabe Harukuni , Nishitani Keiko 
Published: April 2015

ABSTRACTTwo psoriatic patients were treated with an exothermic pad, “Erhitzen”, on one site, and Goeckerman's regimen on the contra‐lateral site. Erhitzen produced quicker clearing and longer duration of remission than Goeckerman's regimen.No serious side effects were observed.
POSSIBLE BINDING OF EPIDERMOLYTIC TOXIN TO A SUBCELLULAR FRACTION OF THE EPIDERMIS
Authors: Nishioka Kiyoshi , Katayama Ichiro , Sano Shigeharu 
Published: April 2015

ABSTRACTAn in vitro method for assessing the activity of epidermolytic toxin (ET) was developed in this study. It was almost equal in sensitivity to the in vivo assay system in which ET was injected subcutaneously into new‐born mice. By using the in vitro method it was found that ET could induce epidermal splitting after incubation with the skin only for 5 minutes. No epidermolytic activity remained in the reaction mixture. The activity of ET was not abolished by proteinase inhibitors such as Trasylol, ε‐aminocaproic acid or soy bean trypsin inhibitor. It was abolished by an extract from the epidermis of new‐born mice. The inhibitory activity of the extract was preserved by heating at 56°C for 30 minutes. It was destroyed by heating at 80°C for 30 minutes. The activity was found in a subcellular fraction which should contain mitochondria and lysosomes from the epidermal cells. A reduction in the amount of ET was observed in acrylamide gel electrophoresis after incubation of ET with the subcellular fraction. The possible mode of action of ET was discussed.
INFLUENCE OF HISTOCOMPATIBILITY ANTIGENS ON SKIN HOMOGRAFT SURVIVAL IN AN EXTENSIVELY BURNED PATIENT
Authors: Higuchi Dousei , Sei Yoshihiro , Takiuchi Iwao 
Published: April 2015

ABSTRACTThirty‐eight donors were selected from 312 volunteers to be as nearly compatible as possible with the patient's HLA‐A and ‐B antigens.In addition to HLA‐A and ‐B, MLC test was performed between the patient and all but one of the 38 donors (Donor No. 35), and all 38 homografts were applied to the patient at once.The mean survival time of HLA‐A and ‐B‐identical grafts was better than two haplotype‐mismatched grafts. There were no clear differences between 0 and 1, or 1 and 2 haplotype‐mismatched grafts.No definite differences in the survival number at 21 days was observed between HLA‐A and ‐B‐identical grafts and 1 haplotype‐mismatched grafts. However, a significant difference was detected between (0+1) mismatched grafts and 2 mismatched grafts.We were not able to detect any effects of ABO blood antigens or sex on graft survival.
SEZARY'S SYNDROME: A CASE REPORT INCLUDING ULTRASTRUCTURAL AND IMMUNOHISTO‐CHEMICAL CHARACTERIZATION OF THE CELLULAR INFILTRATES
Authors: Katoh Mitsuko , Kizukuri Kei , Jimbow Kowichi 
Published: April 2015

ABSTRACTA case of a 77‐year‐old male with Sézary's syndrome (SS) is reported, including ultrastructural and immunohistochemical characterization of the cellular infiltrates.Atypical lymphocytes in the skin were evaluated at stages of both clinical exacerbation and improvement. During both stages, skin specimens revealed essentially similar findings. They were diffusely infiltrated by atypical lymphocytes with a characteristic nuclear convolution. The infiltrating cells exhibited T‐cell markers which cross‐reacted with the T‐cells of the lymph nodes. Atypical convoluted cells in the peripheral blood were PAS positive and peroxidase negative. The morphological and functional characteristics of the cellular infiltrates in SS and its clinical independence from mycosis fungoides were discussed.
CHEMOIMMUNOTHERAPY FOR MELANOMA WITH DTIC, ACNU, VCR AND OK432
Authors: Jimbow Kowichi , Yanbe Hideko , Nishio Chieko 
Published: April 2015

ABSTRACTCombination chemotherapy (DTIC and VCR plus a new derivative of nitrosourea, ACNU) with a new immunoadjuvant of OK432 were evaluated as treatment for disseminated malignant melanoma.Eight subjects with this chemoimmunotherapy showed a significant increase in survival rate (p=0.037 at 8 months), when compared with 11 subjects on other therapy. The regimens were minimally myelo‐suppressive and toxic to liver functions. Cellular immunity with specific mitogens of autologous and allogeneic melanoma cells (MLTC) and non‐specific mitogens of PHA, Con A and PWM was well preserved. Cell‐mediated cytotoxicity against autologous melanoma cells appeared to be stimulated in a way similar to that which occurs with BCG immunoadjuvant therapy.