bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistent albuminuria and chronic kidney disease in adults with sickle cell anaemia: Results from a multicenter natural history study
Authors: Zhou Laura Y. , Derebail Vimal K. , Desai Payal C. , Elsherif Laila , Patillo Kammie L. , McCune Paula , Wichlan David , Landes Kristina , Ogu Ugochi O. , Nelson Marquita , Loehr Laura R. , Cronin Robert M. , Tang Yihan , Cai Jianwen , Ataga Kenneth I. 
Published: July 2024

SummaryClinical and laboratory correlates of chronic kidney disease (CKD) in sickle cell anaemia remain incompletely defined. In a multicenter cohort study, we evaluated the prevalence of persistent albuminuria (PA) and characteristics associated with PA, albumin–creatinine ratio (ACR) and decreased estimated glomerular filtration rate (eGFR) using logistic, linear and multinomial regression models, respectively. Of 269 participants (median age: 30 years; 57.2% females), the prevalence of PA was 35.7%. Using baseline ACR values of <100 and ≥100 mg/g, the probabilities of PA were 30.0% and 94.6%, respectively. In multivariable logistic regression analyses, male sex (β = 0.80 [SE = 0.36], p = 0.024) and ACE inhibitors/ARBs use (β = 1.54 [SE = 0.43], p < 0.001) were associated with higher likelihoods of PA, while higher haemoglobin (β = −0.33 [SE = 0.13], p = 0.009) and HbF (β = −0.04 [SE = 0.02], p = 0.041) were associated with lower likelihoods of PA. In multivariable multinomial regression analyses, older age (β = 0.06 [SE = 0.02], p = 0.004) and higher alkaline phosphatase (β = 0.01 [SE = 0.00], p = 0.004) were associated with higher odds of having eGFR 60–90 versus eGFR>90 mL/min/1.73 m2 using the cystatin C‐based CKD‐EPI‐2012 equation. Additionally, higher systolic blood pressure (β = 0.11 [SE = 0.03], p = 0.001) and blood urea nitrogen (β = 0.45 [SE = 0.12], p < 0.001) were associated with higher odds, while higher haemoglobin (β = −1.22 [SE = 0.43], p = 0.004) was associated with lower odds of having eGFR<60 versus eGFR>90 mL/min/1.73 m2. PA and decreased eGFR are associated with measures of disease severity and comorbid conditions (Clinicaltrials.gov Identifier: NCT03277547).
Motivations to engage in collective action: A latent profile analysis of refugee supporters
Authors: Yip Lisette , Thomas Emma F. , Bliuc Ana‐Maria , Boza Mihaela , Kende Anna , Lizzio‐Wilson Morgana , Reese Gerhard , Smith Laura G. E. 
Published: July 2024

AbstractWhat motivates people to participate in collective action? Some actions such as symbolic or online actions are often critiqued as performative allyship, motivated by personal gain rather than genuine concern for the cause. We aim to adjudicate this argument by examining the quality of motivations for acting, drawing on the insights of self‐determination theory and the social identity approach. Using latent profile analysis, we examined whether there are different types of supporters of refugees based on their underlying motives. In Study 1, we surveyed supporters of Syrian refugees from six nations (N = 936) and measured autonomous and controlled motivation, pro‐refugee identification and collective action. In Study 2 (N = 1994), we surveyed supporters of Ukrainian refugees in Romania, Hungary and the UK. We found 4–5 profiles in each sample and consistently found that supporters with high autonomous motivation take more action than disengaged or ambivalent supporters (low/neutral on all motives). However, contrary to the tenets of self‐determination theory, those high in both autonomous and controlled motives were the most engaged. We conclude that the most committed supporters are those with multiple motives, but further research is needed on the role of controlled motivation.
Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation
Authors: Lopez‐Balastegui Marta , Stepniewski Tomasz Maciej , Kogut‐Günthel Małgorzata M. , Di Pizio Antonella , Rosenkilde Mette Marie , Mao Jiafei , Selent Jana 
Published: July 2024

AbstractG protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly flexible entities with the ability to adopt different conformational states that elicit different physiological responses. Including this knowledge in the drug discovery pipeline can help to tailor novel conformation‐specific drugs with an improved therapeutic profile. In this review, we outline our current knowledge about GPCR dynamics that is relevant for receptor activation, signalling bias and allosteric modulation. Ultimately, we highlight new technological implementations such as time‐resolved X‐ray crystallography and cryo‐EM as well as computational algorithms that can contribute to a more comprehensive understanding of receptor dynamics and its relevance for GPCR functionality.
Intravenous Immunoglobulins Alone for the Desensitization of Lung Transplant Recipients with Preformed Donor Specific Antibodies and Negative Flow Cytometry Crossmatch
Authors: Abdulqawi Rayid , Alawwami Moheeb , Aldosari Omar , Aldosari Zyad , Alhuqbani Mohammed , Saleh Rana A. , Esendagli Dorina , Aldakhil Haifa , De Vol Edward B. , Alkattan Khaled , Marquez Kris Ann H. , Saleh Waleed , Sandoqa Sahar , Al‐Mutairy Eid A. 
Published: July 2024

ABSTRACTBackgroundThe lack of evidence regarding optimal desensitization strategies for lung transplant candidates with preformed donor specific anti‐human leukocyte antigen antibodies (DSAs) has led to varying approaches among centers towards this patient group. Our institution's desensitization protocol for recipients with preformed DSAs and negative flow cytometry crossmatch (FCXM) consists of intravenous immunoglobulin (IVIG) as the sole therapy. The study aimed to determine outcomes using this approach.MethodsThis retrospective study included adults who underwent lung‐only transplantation for the first time between January 2015 and March 2022 at a single center. We excluded patients with positive or missing FCXM results. Transplant recipients with any DSA ≥ 1000 MFI on latest testing within three months of transplant were considered DSA‐positive, while recipients with DSAs <1000 MFI and those without DSAs were assigned to the low‐level/negative group. Graft survival (time to death/retransplantation) and chronic lung allograft dysfunction (CLAD)‐free times were compared between groups using Cox proportional hazards models.ResultsThirty‐six out of 167 eligible patients (22%) were DSA‐positive. At least 50% of preformed DSAs had documented clearance (decrease to <1000 MFI) within the first 6 months of transplant. Multivariable Cox regression analyses did not detect a significantly increased risk of graft failure (aHR 1.04 95%CI 0.55–1.97) or chronic lung allograft dysfunction (aHR 0.71 95%CI 0.34–1.52) in DSA‐positive patients compared to patients with low‐level/negative DSAs. Incidences of antibody‐mediated rejection (p = 1.00) and serious thromboembolic events (p = 0.63) did not differ between study groups.ConclusionWe describe a single‐center experience of administering IVIG alone to lung transplant recipients with preformed DSAs and negative FCXM. Further studies are required to confirm the efficacy of this strategy against other protocols.
Front Cover
Authors: Cheung Johnny T. K. , Yang Aimin , Wu Hongjiang , Lau Eric S. H. , Lui Juliana , Kong Alice P. S. , Ma Ronald C. W. , Luk Andrea O. Y. , Chow Elaine , Chan Juliana C. N. 
Published: July 2024

The cover image is based on the Original Article Association of dipeptidyl peptidase‐4 inhibitor initiation at glycated haemoglobin <7.5% with reduced major clinical events mediated by low glycated haemoglobin variability by Johnny T. K. Cheung MBChB and Aimin Yang PhD et al., https://doi.org/10.1111/dom.15662.image
Review of speckle tracking analysis to measure the size, shape, and contractility of the fetal heart in fetuses with congenital heart defects
Authors: DeVore Greggory R. , Klas Berthold , Cuneo Bettina , Satou Gary , Sklansky Mark 
Published: July 2024

AbstractEvaluation of the fetal heart involves two approaches. The first describes a screening protocol in which the heart is imaged in transverse planes that includes the four‐chamber view (4CV), left and right outflow tracts, and the 3‐vessel‐tracheal view. The second approach is a fetal echocardiogram that requires additional cardiac images as well as evaluating ventricular function using diagnostic tools such as M‐mode and pulsed Doppler ultrasound. Speckle tracking analysis of the ventricular and atrial endocardium of the fetal heart has focused primarily on computing longitudinal global strain. However, the technology enabling this measurement to occur has recently been adapted to enable the clinician to obtain numerous additional measurements of the size, shape, and contractility of the ventricles and atrial chambers. By using the increased number of measurements derived from speckle tracking analysis, we have reported the ability to screen for tetralogy of Fallot, D‐transposition of the great arteries (D‐TGA), and coarctation of the aorta by only imaging the 4CV. In addition, we have found that measurements derived from speckle tracking analysis of the ventricular and atrial chambers can be used to compute the risk for emergent neonatal balloon atrial septostomy in fetuses with D‐TGA. The purpose of this review is to consolidate our experience in one source to provide perspective on the benefits of speckle tracking analysis to measure the size, shape, and contractility of the ventricles and atria imaged in the 4CV in fetuses with congenital heart defects.
Caregiving stress and maternal mental health during the COVID‐19 pandemic
Authors: Quigley Kelsey M. , Kwon Rachel , Nelson Charles A. , Bosquet Enlow Michelle 
Published: July 2024

AbstractIt has now been extensively documented that parental mental health has deteriorated since the beginning of the COVID‐19 pandemic. Although pandemic‐related stress has been widespread, parents faced the unique challenge of navigating remote schooling. Parental oversight of children's education, loss of access to school supportive resources, and the challenges of remote learning may have been most problematic for parents of children with or at elevated risk for mental health difficulties. In the current study, we examined interactive effects of parent‐reported pandemic‐related caregiving stress and child internalizing and externalizing problems on parental depressive symptoms in a community‐based cohort (N = 115) in the Northeast of the United States. Results indicated that parents experiencing higher levels of pandemic‐related caregiving stress whose children exhibited elevated externalizing behaviors reported heightened levels of depressive symptoms. Greater child internalizing problems were associated with higher parental depressive symptoms independent of caregiving stress. These findings point to conditions that might heighten risk for parent mental health challenges in the context of ongoing remote or hybrid learning and pandemic‐associated restrictions. Further, the findings point to conditions and characteristics that may be screened to identify and intervene with vulnerable families to mitigate mental health problems.
TLR9‐dependent dendritic cell maturation promotes IL‐6‐mediated upregulation of cathepsin X
Authors: Xu Bangyan , Anderson Bethany M , Mintern Justine D , Edgington‐Mitchell Laura E 
Published: July 2024

AbstractCysteine cathepsins are lysosomal proteases subject to dynamic regulation within antigen‐presenting cells during the immune response and associated diseases. To investigate the regulation of cathepsin X, a carboxy‐mono‐exopeptidase, during maturation of dendritic cells (DCs), we exposed immortalized mouse DCs to various Toll‐like receptor agonists. Using a cathepsin X‐selective activity‐based probe, sCy5‐Nle‐SY, we observed a significant increase in cathepsin X activation upon TLR‐9 agonism with CpG, and to a lesser extent with Pam3 (TLR1/2), FSL‐1 (TLR2/6) and LPS (TLR4). Despite clear maturation of DCs in response to Poly I:C (TLR3), cathepsin X activity was only slightly increased by this agonist, suggesting differential regulation of cathepsin X downstream of TLR activation. We demonstrated that cathepsin X was upregulated at the transcriptional level in response to CpG. This occurred at late time points and was not dampened by NF‐κB inhibition. Factors secreted from CpG‐treated cells were able to provoke cathepsin X upregulation when applied to naïve cells. Among these factors was IL‐6, which on its own was sufficient to induce transcriptional upregulation and activation of cathepsin X. IL‐6 is highly secreted by DCs in response to CpG but much less so in response to poly I:C, and inhibition of the IL‐6 receptor subunit glycoprotein 130 prevented CpG‐mediated cathepsin X upregulation. Collectively, these results demonstrate that cathepsin X is differentially transcribed during DC maturation in response to diverse stimuli, and that secreted IL‐6 is critical for its dynamic regulation.
Alike but genetically divergent: The resurrection of Urotrygon asterias (Jordan & Gilbert, 1883) from its closest relatives, the Munda and the Blotched stingray
Authors: Ehemann Nicolás Roberto , Hernández Sebastían , Siccha‐Ramírez Raquel , García‐Rodríguez Francisco Javier , De La Cruz‐Agüero José 
Published: July 2024

AbstractThe genus Urotrygon comprises small‐ to medium‐sized endemic round rays on the American continent and has undergone several synonymization processes. Here, we used an integrative taxonomic approach, including meristic, morphometric, and mtDNA analyses, to resolve the particularly intricate relationship among Urotrygon munda Gill, 1863, Urotrygon chilensis (Günther, 1872), and Urotrygon asterias (Jordan & Gilbert, 1883). The latter species is currently a synonym of U. munda but is also considered the U. chilensis “northern morphotype.” These taxonomic entities have historically been confounded, mainly due to their phenotypical resemblance along their geographic distribution in the eastern Pacific. We assessed 78 specimens (43 “northern” and 30 “southern morphotypes” of U. chilensis, as well as 5 U. munda) using 19 external variables for taxonomic and morphometric analysis. Distinct meristic patterns, including pectoral and pelvic ceratotrichia, vertebrae number, and thorn distribution along the dorsal midline, were observed in the series‐type specimens of the three taxonomic entities. Our multivariate morphometric analyses consistently differentiated the three groups as distinct taxonomic entities, with an overall classification accuracy of 66.7%. The meristic results also provided reliable information distinguishing the three entities. Based on the nicotinamide adenine dinucleotide (NADH2) and cytochrome oxidase subunit I (COI) genes, our phylogenetic analysis were consistent with the morphometric and meristic data, supporting these three entities as distinct species having their own evolutionary lineages. Our comprehensive approach confidently demonstrated that the northern U. chilensis morphotype matched and corresponded to the description of the Starry round ray, U. asterias, confirming its taxonomic resurrection as a valid species distinct from U. chilensis and U. munda. The geographic distribution of U. asterias spans from the tropical west coast of Mexico (including the Gulf of California) to Costa Rica, revealing that microevolutionary processes have well‐defined population clades within this range. Furthermore, U. chilensis is unequivocally established as the sole Urotrygon species occurring south of the Guayaquil marine ecoregion. In addition, the public COI and NADH2 sequences available for Urotrygon hosted in the ad hoc online databases were found to be misidentified, emphasizing the need for rigorous taxonomic scrutiny in this group. Finally, our research underscores the significance of an integrative approach that combines morphometric, meristic, and molecular techniques with historical data to disentangle the complexities of closely related taxa.
Family management and corporate charitable donations in Chinese family firms: An inverted u‐shaped relationship
Authors: You Xialei , Su Emma , Dou Junsheng 
Published: July 2024

AbstractThis paper examines the influence of family management on corporate charitable donations. Drawing from the literature on socioemotional wealth, we propose that the level of family management and corporate charitable donations presents an inverted U‐shaped relationship, and that this inverted U‐shaped relationship is weakened by firm diversification levels and an unfair competition environment. An analysis of a comprehensive data set comprising 9266 firm‐year observations, encompassing 1445 publicly listed Chinese family firms from 2010 to 2021, provides empirical support for our hypotheses. The results remain robust when accounting for endogeneity concerns. This study contributes to the growing body of research on environmental, social, and governance in the field of finance and accounting, and enhances our knowledge of sustainability practices in family firms.
Mechanisms of vacuolar phosphate efflux supporting soybean root hair growth in response to phosphate deficiency
Authors: Shan Zhong , Chu Yanli , Sun Guangfang , Chen Rui , Yan Jun , He Qiwei , Liu Yingna , Wang Bin , Luan Mingda , Lan Wenzhi 
Published: July 2024

ABSTRACTPhosphorus is an essential macronutrient for plant growth and development. In response to phosphate (Pi) deficiency, plants rapidly produce a substitutive amount of root hairs; however, the mechanisms underlying Pi supply for root hair growth remain unclear. Here, we observed that soybean (Glycine max) plants maintain a consistent level of Pi within root hairs even under external Pi deficiency. We therefore investigated the role of vacuole‐stored Pi, a major Pi reservoir in plant cells, in supporting root hair growth under Pi‐deficient conditions. Our findings indicated that two vacuolar Pi efflux (VPE) transporters, GmVPE1 and GmVPE2, remobilize vacuolar stored Pi to sustain cytosolic Pi content in root hair cells. Genetic analysis showed that double mutants of GmVPE1 and GmVPE2 exhibited reduced root hair growth under low Pi conditions. Moreover, GmVPE1 and GmVPE2 were highly expressed in root hairs, with their expression levels significantly upregulated by low Pi treatment. Further analysis revealed that GmRSL2 (ROOT HAIR DEFECTIVE 6‐like 2), a transcription factor involved in root hair morphogenesis, directly binds to the promoter regions of GmVPE1 and GmVPE2, and promotes their expressions under low Pi conditions. Additionally, mutants lacking both GmRSL2 and its homolog GmRSL3 exhibited impaired root hair growth under low Pi stress, which was rescued by overexpressing either GmVPE1 or GmVPE2. Taken together, our study has identified a module comprising vacuolar Pi exporters and transcription factors responsible for remobilizing vacuolar Pi to support root hair growth in response to Pi deficiency in soybean.
The Role of Midwives in US Perinatal Palliative Care: A Scoping Review
Authors: Schafer Robyn , LoGiudice Jenna A. , Hargwood Pamela , Wilpers Abigail 
Published: July 2024

IntroductionPerinatal palliative care (PPC) is a rapidly growing and essential reproductive health care option for pregnant persons with a diagnosed life‐limiting fetal condition who continue their pregnancy. The provision of PPC is within the scope of basic midwifery competencies, and midwives are well‐positioned to make unique and valuable contributions to interprofessional PPC teams. However, little is known about midwives’ past or current involvement in PPC in the United States.MethodsThis scoping review of the literature investigated what is known about the role of midwives in PPC in the United States. Multiple databases of published literature were used for this review: PubMed, CINAHL, Embase, Web of Science, ProQuest, Google Scholar, and relevant citations from identified studies. All types of English language publications addressing midwives’ involvement in PPC in the United States were included, without any limitations on publication date.ResultsThe role and contributions of midwives in PPC is not well represented in existing literature. Of the 259 results identified, 7 publications met criteria for inclusion. These included 5 case reports, one quantitative research article, and one conference abstract. Midwives are involved in PPC through the provision of direct clinical care (including antepartum, intrapartum, postpartum, neonatal, bereavement, postmortem, and follow‐up care) and care planning and coordination as part of an interprofessional team.DiscussionDespite midwives being uniquely positioned to provide holistic, family‐centered, and person‐centered care in situations of pregnancy with life‐limiting fetal conditions, there is limited literature about their involvement in PPC in the United States. PPC should be incorporated into midwifery education and training programs. Midwives should play a central role in shaping future research and policies to ensure the accessibility and quality of PPC.
European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well‐differentiated small intestine neuroendocrine tumours
Authors: Lamarca Angela , Bartsch Detlef K. , Caplin Martyn , Kos‐Kudla Beata , Kjaer Andreas , Partelli Stefano , Rinke Anja , Janson Eva Tiensuu , Thirlwell Christina , van Velthuysen Marie‐Louise F. , Vullierme Marie‐Pierre , Pavel Marianne 
Published: July 2024

AbstractBoth the incidence and prevalence of well‐differentiated neuroendocrine tumours from the small intestine (Si‐NET) are gradually increasing. Most patients have non‐functioning tumours with subtle GI symptoms and tumours are often discovered incidentally by endoscopy or at advanced disease stages by imaging depicting mesenteric lymph node and /or liver metastases while around 30% of the patients present with symptoms of the carcinoid syndrome. Adequate biochemical assessment and staging including functional imaging is crucial for treatment‐related decision‐making that should take place in an expert multidisciplinary team setting. Preferably, patients should be referred to specialised ENETS Centres of Excellence or centres of high expertise in the field. This guidance paper provides the current evidence and best knowledge for the management of Si‐NET grade (G) 1–3 following 10 key questions of practical relevance for the diagnostic and therapeutic decision making.