bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of using bentonite during fermentation on protein stabilisation and sensory properties of white wine
Authors: Lira Eugenio , Salazar Fernando N. , Rodríguez‐Bencomo Juan J. , Vincenzi Simone , Curioni Andrea , López Francisco 
Published: November 2013

SummaryThe bentonite use to remove proteins from white wine is a widespread practice that prevents protein haze formation after bottling. However, an excess of bentonite can have negative effects on both the aromatic profile of young white wines and the quality of the foam of sparkling wines. Therefore, the optimisation of bentonite amount to be used and the moment of its application during winemaking to minimise wine quality losses are of great interest for winemakers. This paper analyses how applying an equal bentonite dose at different stages (must clarification; beginning, middle and end of fermentation) on two scales (industrial and pilot) affects the protein content and stability, physical–chemical characteristics, aromatic profile and foam quality of the obtained wines. No important differences in the oenological parameters were observed between industrial and pilot scales, whereas the scale of the experimental treatments affected protein stability, aroma composition and foam quality of the wines.
Extraction and physicochemical properties of soya bean protein and oil by a new reverse micelle system compared with other extraction methods
Authors: Bu Guanhao , Yang Yingying , Chen Fusheng , Liao Zhixiong , Gao Yanxiu , Yang Hongshun , Li Runjie , Liu Kunlun , Zhao Junting 
Published: November 2013

SummaryReverse micelle extraction is a novel technology for the separation of plant components such as proteins and oil. In this study, sodium bis(2‐ethylhexyl) sulphosuccinate (AOT) reverse micelle system and AOT/Tween 85 reverse micelle system were used to extract soya bean protein and oil from soya bean flour. The physicochemical properties of the protein and oil extracted were investigated and compared with traditional extraction methods. The results showed that the efficiency of forward extraction of soya bean protein using an AOT/Tween 85 reverse micelle system was superior to that using an AOT reverse micelle system at the optimal extraction conditions. In addition, soya bean proteins extracted using reverse micelle extraction had no unordered structure under Fourier transform infrared spectroscopy. The acid and peroxide values of oil products from two reverse micelle extractions were lower than that from immersion. The results indicated that AOT/Tween 85 reverse micelle system is effective in extracting soya bean protein and oil.
The split plot with repeated randomised complete block design can reduce psychological biases in consumer acceptance testing
Authors: Jirangrat Wannita , Wang Jing , Sriwattana Sujinda , No Hong Kyoon , Prinyawiwatkul Witoon 
Published: November 2013

SummaryA randomised complete block design (RCBD) has been extensively used in consumer testing; however, it is ineffective in preventing sample presentation biases. This study demonstrated a more efficient experimental design [i.e. split plot with repeated randomised complete block design (SPRRCBD)] to help minimise positional and first serving‐order (FSO) biases in consumer tests. Results suggested that positional biases were strongly pronounced for the poor‐quality sample. Comparing between RCBD and RCBD without FSO experiments, there were significant differences in overall liking (OL) scores of the same sample served at the same position. Hence, omitting the first sample score from data analysis was not recommended. The mean‐squared error (MSE) of SPRRCBD was lower than RCBD and RCBD without FSO (2.28, 2.72 and 2.60, respectively), indicating a more powerful design to explain variations in mean hedonic differences. SPRRCBD extracted more explained variances, resulting in a decreased Type‐II error in the model.
Textural properties of yogurts with green tea and Pu‐erh tea additive
Authors: Najgebauer‐Lejko Dorota , Żmudziński Daniel , Ptaszek Anna , Socha Robert 
Published: November 2013

SummarySet‐style yogurts enriched with green tea or Pu‐erh tea infusions in three concentrations, that is, 5%, 10% and 15% (v/v), and the nonsupplemented yogurts were produced. The obtained cultured milk treatments were subjected to the analyses of acidity, viscoelastic properties, back extrusion parameters, susceptibility to syneresis and instrumental colour analysis. As revealed by the performed HPLC and spectrophotometric studies, the two types of tea differed greatly in their polyphenolic composition which was further reflected in the physicochemical properties of yogurt gels. Results indicate that yogurts varied as regards textural properties depending on the type of tea applied as well as tea concentration. Green tea incorporation, which contained significantly higher amounts of catechins, produced yogurts with increased titratable acidity, better mechanical properties and less susceptible to syneresis, while yogurt gels with Pu‐erh tea were firmer, less elastic and with visible syneresis at higher (10%, 15%) tea concentrations.
The Burden of Stroke in México
Authors: Marquez-Romero Juan M , Arauz Antonio , Góngora-Rivera Fernando , Barinagarrementeria Fernando , Cantú Carlos 
Published: November 2013

Regrettably, stroke has been scarcely studied in México, and the available data suffer from great variability in diagnostic testing, risk factor definitions, and poor generalizability. The current cumulative incidence of stroke in Mexico is 232·2 per 100 000, whereas prevalence among people aged 60 years or older is 18·2 per 1000. Hypertension and diabetes are the main risk factors. Ischemic stroke is the most frequent sub-type. Stroke mortality has been increasing during last years, and 30-day case fatality rate doubles at one-year follow-up. A remarkable finding of a hospital-based registry was that most of ischemic stroke cases are of undetermined etiology and even when a quarter of patients arrive on time for thrombolysis, less than 1% received this management.
Complications following Incident Stroke Resulting in Readmissions: An Analysis of Data from Three Scottish Health Surveys
Authors: Ponomarev Dmitry , Miller Claire , Govan Lindsay , Haig Caroline , Wu Olivia , Langhorne Peter 
Published: November 2013

Background and aims Stroke is widely recognized as the major contributor to morbidity and mortality in the United Kingdom. We analyzed the data obtained from the three consecutive Scottish Health Surveys and the Scottish Morbidity records, with the aim of identifying risk factors for, and timing of, common poststroke complications. Methods There were 19434 individuals sampled during three Scottish Health Surveys in 1995, 1998, and 2001. For these individuals their morbidity and mortality outcomes were obtained in 2007. Incident stroke prevalence, risk factors for a range of poststroke complications, and average times until such complications in the sample were established. Results Of the total of 168 incident stroke admissions (0·86% of the survey), 16·1% people died during incident stroke hospitalization. Of the remaining 141 stroke survivors, 75·2% were rehospitalized at least once. The most frequent reason for readmission after stroke was a cardiovascular complication (28·6%), median time until event 1412 days, followed by infection (17·3%, median 1591 days). The risk of cardiovascular readmission was higher in those with ‘poor’ self-assessed health (odds ratio 7·70; 95% confidence interval 1·64–43·27), smokers (odds ratio 4·24; 95% confidence interval 1·11–21·59), and doubled with every five years increase in age (odds ratio 1·97; 95% confidence interval 1·46–2·65). ‘Poor’ self-assessed health increased chance of readmission for infection (odds ratio 14·11; 95% confidence interval 2·27–276·56). Conclusions Cardiovascular events and infections are the most frequent poststroke complications resulting in readmissions. The time period until event provides a possibility to focus monitoring on those people at risk of readmission and introduce preventative measures, thereby reducing readmission-associated costs.
Occlusion Site Does Not Impact Outcome in Patients with Carotid Stroke Undergoing Endovascular Reperfusion
Authors: Leker Ronen R. , Eichel Roni , Keigler Galina , Gomori John M. , Cohen Jose E. 
Published: November 2013

Background It remains unclear whether occlusion site impacts outcome in patients with acute carotid artery occlusions. Methods Patients with acute carotid artery occlusion that underwent endovascular reperfusion treatments were prospectively enrolled. Patients with extracranial carotid bifurcation occlusions were compared with those with intracranial carotid-T-occlusions. Collected data included demographics, risk factor profile, and procedure-related variables. Neurological deficits were studied with the National Institutes of Health Stroke Scale and outcome was studied with the modified Rankin Score at day 90 after stroke and dichotomized into favorable (≤2) or unfavorable (>3). Recanalization status was studied with the thrombolysis in cerebral infarction scale. Results We included 51 patients (33 with extracranial bifurcation occlusion and 18 with intracranial T-occlusion). Patients with T lesions were significantly older (median 74 versus 56 years, P = 0·02), more frequently had atrial fibrillation (61% versus 18%; P = 0·005) and cardioembolism (78% versus 21% P = 0·001), smoked less often (6% versus 42%; P = 0·01), and less often required stent implantation (11% versus 48%; P = 0·015). However, neurological severity, other procedure and peri-procedure-related variables including recanalization rates and percentages of symptomatic hemorrhages did not differ between the groups. Mortality rates (24% versus 23%) and chances for favorable outcomes (33% versus 24%) did not significantly differ. On multivariate logistic regression analysis, occlusion location was not a significant modifier of outcome. Conclusions Despite differences in stroke risk factors and treatments used between patients with extracranial bifurcation and intracranial T-occlusions, lesion location in itself does not influence outcome in patients with acute carotid artery occlusion treated with endovascular reperfusion.
Management of Fever, Hyperglycemia, and Swallowing Dysfunction following Hospital Admission for Acute Stroke in New South Wales, Australia
Authors: Drury Peta , Levi Christopher , McInnes Elizabeth , Hardy Jennifer , Ward Jeanette , Grimshaw Jeremy M. , Este Catherine D' , Dale Simeon , McElduff Patrick , Cheung N Wah , Quinn Clare , Griffiths Rhonda , Evans Malcolm , Cadilhac Dominique , Middleton Sandy 
Published: November 2013

Background Fever, hyperglycemia, and swallow dysfunction poststroke are associated with significantly worse outcomes. We report treatment and monitoring practices for these three items from a cohort of acute stroke patients prior to randomization in the Quality in Acute Stroke Care trial. Method Retrospective medical record audits were undertaken for prospective patients from 19 stroke units. For the first three-days following stroke, we recorded all temperature readings and administration of paracetamol for fever (≥37.5°C) and all glucose readings and administration of insulin for hyperglycemia (>11 mmol/L). We also recorded swallow screening and assessment during the first 24 h of admission. Results Data for 718 (98%) patients were available; 138 (19%) had four hourly or more temperature readings and 204 patients (29%) had a fever, with 44 (22%) receiving paracetamol. A quarter of patients ( n = 102/412, 25%) had six hourly or more glucose readings and 23% (95/412) had hyperglycemia, with 31% (29/95) of these treated with insulin. The majority of patients received a swallow assessment ( n = 562, 78%) by a speech pathologist in the first instance rather than a swallow screen by a nonspeech pathologist ( n = 156, 22%). Of those who passed a screen ( n = 108 of 156, 69%), 68% ( n = 73) were reassessed by a speech pathologist and 97% ( n = 71) were reconfirmed to be able to swallow safely. Conclusions Our results showed that acute stroke patients were: undermonitored and undertreated for fever and hyperglycemia; and underscreened for swallowing dysfunction and unnecessarily reassessed by a speech pathologist, indicating the need for urgent behavior change.
Differential Effects of Paracrine Factors on the Survival of Cells of the Neurovascular Unit during Oxygen Glucose Deprivation
Authors: Redzic Zoran B. , Rabie Tamer , Sutherland Brad A. , Buchan Alastair M. 
Published: November 2013

Background Disruption of the neurovascular unit following cerebral ischemia affects protetive function of the blood-brain barrier, thus contributing to vasogenic edema and hemorrhagic transformation. Aims This study explored the effects of mediators released from neurovascular unit cells on death of brain endothelial cells, astrocytes, pericytes, and microglia during oxygen glucose deprivation. Methods Rat primary cell cultures were exposed either to oxygen glucose deprivation or control conditions. Cell death and released angiogenic factors were assessed from media collected from cultures. For some experiments, astrocyte-conditioned media, pericyte-conditioned media, and microglia-conditioned media, collected from the corresponding cell culture after six-hour oxygen glucose deprivation, were added to the media during oxygen glucose deprivation incubations. Results Brain endothelial cells were more susceptible to death following oxygen glucose deprivation than other neurovascular unit cells. Neither astrocyte-conditioned media nor vascular endothelial growth factor165 were protective for pericytes or brain endothelial cells during oxygen glucose deprivation. Vascular endothelial growth factor receptor antagonist significantly reduced cell death of brain endothelial cells treated with astrocyte-conditioned media or vascular endothelial growth factor165. Pericyte-conditioned media were protective for brain endothelial cells and microglia, but this was not mediated by pericyte-released angiopoietin 1. Soluble angiopoietin 1/angiopoietin 2 receptor Tie2 was protective for brain endothelial cells. Microglia-conditioned media were protective for astrocytes and brain endothelial cells, possibly through transforming growth factor β1 or interleukin 6. Conclusion Microglia-derived signaling molecules, but not angiogenic factors, were protective for neurovascular unit cells during oxygen glucose deprivation. This finding could identify a potential therapeutic target for ischemic stroke.
A Multicenter, Randomized, Controlled Study to Investigate Extending the Time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial Therapy (EXTEND-IA)
Authors: Campbell Bruce C. V. , Mitchell Peter J. , Yan Bernard , Parsons Mark W. , Christensen Søren , Churilov Leonid , Dowling Richard J. , Dewey Helen , Brooks Mark , Miteff Ferdinand , Levi Christopher , Krause Martin , Harrington Timothy J. , Faulder Kenneth C. , Steinfort Brendan S. , Kleinig Timothy , Scroop Rebecca , Chryssidis Steve , Barber Alan , Hope Ayton , Moriarty Maurice , McGuinness Ben , Wong Andrew A. , Coulthard Alan , Wijeratne Tissa , Lee Andrew , Jannes Jim , Leyden James , Phan Thanh G. , Chong Winston , Holt Michael E. , Chandra Ronil V. , Bladin Christopher F. , Badve Monica , Rice Henry , de Villiers Laetitia , Ma Henry , Desmond Patricia M. , Donnan Geoffrey A. , Davis Stephen M. 
Published: November 2013

Background and Hypothesis Thrombolysis with tissue plasminogen activator is proven to reduce disability when given within 4.5 h of ischemic stroke onset. However, tissue plasminogen activator only succeeds in recanalizing large vessel arterial occlusion in a minority of patients. We hypothesized that anterior circulation ischemic stroke patients, selected with ‘dual target’ vessel occlusion and evidence of salvageable brain using computed tomography or magnetic resonance imaging ‘mismatch’ within 4.5 h of onset, would have improved reperfusion and early neurological improvement when treated with intra-arterial clot retrieval after intravenous tissue plasminogen activator compared with intravenous tissue plasminogen activator alone. Study Design EXTEND-IA is an investigator-initiated, phase II, multicenter prospective, randomized, open-label, blinded-endpoint study. Ischemic stroke patients receiving standard 0.9 mg/kg intravenous tissue plasminogen activator within 4.5 h of stroke onset who have good prestroke functional status (modified Rankin Scale <2, no upper age limit) will undergo multimodal computed tomography or magnetic resonance imaging. Patients who also meet dual target imaging criteria: vessel occlusion (internal carotid or middle cerebral artery) and mismatch (perfusion lesion: ischemic core mismatch ratio >1.2, absolute mismatch >10 ml, ischemic core volume <70 ml) will be randomized to either clot retrieval with the Solitaire FR device after full dose intravenous tissue plasminogen activator, or tissue plasminogen activator alone. Study Outcomes The coprimary outcome measure will be reperfusion at 24 h and favorable clinical response (reduction in National Institutes of Health Stroke Scale by ≥8 points or reaching 0–1) at day 3. Secondary outcomes include modified Rankin Scale at day 90, death, and symptomatic intracranial hemorrhage.
A Score Based on Age and DWI Volume Predicts Poor Outcome following Endovascular Treatment for Acute Ischemic Stroke
Authors: Liggins John T. P. , Yoo Albert J. , Mishra Nishant K. , Wheeler Hayley M. , Straka Matus , Leslie-Mazwi Thabele M. , Chaudhry Zeshan A. , Kemp Stephanie , Mlynash Michael , Bammer Roland , Albers Gregory W. , Lansberg Maarten G. 
Published: November 2013

Background and Aims The Houston Intra-Arterial Therapy score predicts poor functional outcome following endovascular treatment for acute ischemic stroke based on clinical variables. The present study sought to (a) create a predictive scoring system that included a neuroimaging variable and (b) determine if the scoring systems predict the clinical response to reperfusion. Methods Separate datasets were used to derive ( n = 110 from the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 study) and validate ( n= 125 from Massachusetts General Hospital) scoring systems that predict poor functional outcome, defined as a modified Rankin Scale score of 4–6 at 90 days. Results Age ( P < 0·001; β = 0·087) and diffusion-weighted imaging volume ( P= 0·023; β = 0·025) were the independent predictors of poor functional outcome. The Stanford Age and Diffusion-Weighted Imaging score was created based on the patient's age (0–3 points) and diffusion-weighted imaging lesion volume (0–1 points). The percentage of patients with a poor functional outcome increased significantly with the number of points on the Stanford Age and Diffusion-Weighted Imaging score ( P < 0·01 for trend). The area under the receiver operating characteristic curve for the Stanford Age and Diffusion-Weighted Imaging score was 0·82 in the derivation dataset. In the validation cohort, the area under the receiver operating characteristic curve was 0·69 for the Stanford Age and Diffusion-Weighted Imaging score and 0·66 for the Houston Intra-Arterial Therapy score ( P = 0·45 for the difference). Reperfusion, but not the interactions between the prediction scores and reperfusion, were predictors of outcome ( P > 0·5). Conclusions The Stanford Age and Diffusion-Weighted Imaging and Houston Intra-Arterial Therapy scores can be used to predict poor functional outcome following endovascular therapy with good accuracy. However, these scores do not predict the clinical response to reperfusion. This limits their utility as tools to select patients for acute stroke interventions.
Replantation of avulsed primary teeth: a systematic review
Authors: Martins‐Júnior Paulo Antônio , Franco Felipe Augusto da Silva , de Barcelos Ramon Valério , Marques Leandro Silva , Ramos‐Jorge Maria Letícia 
Published: November 2013

BackgroundThere is little evidence regarding the risks and benefits of replantation of avulsed primary teeth.AimThe aim of this study was to perform a systematic review of the literature on the replantation of avulsed primary teeth, analysing the risks and benefits to help guide dentists regarding the best clinical decision‐making in such cases.DesignThe Medline/Pubmed, LILACS, and SciELO databases were searched for articles published in English, Portuguese, German or Spanish on the replantation of avulsed primary teeth in dental journals dating from the inception of the databases through to May 2013.ResultsAmong the 891 papers identified in the search, nineteen fulfilled the inclusion criteria. All 19 studies were case reports involving a total of 41 replanted primary teeth. No negative consequences to either the primary tooth or permanent successor were observed in 15 cases. Among the other 26 cases, there were negative consequences to only the replanted primary tooth in 16 cases, only the permanent successor in three cases and both the replanted primary tooth and permanent successor in seven cases.ConclusionThere is a lack of high‐quality studies that can help guide clinicians regarding the best approach in cases of primary tooth avulsion.
An evidence synthesis approach to estimating the incidence of seasonal influenza in the Netherlands
Authors: McDonald Scott A. , Presanis Anne M. , De Angelis Daniela , van der Hoek Wim , Hooiveld Mariette , Donker Gé , Kretzschmar Mirjam E. 
Published: November 2013

ObjectivesTo estimate, using Bayesian evidence synthesis, the age‐group‐specific annual incidence of symptomatic infection with seasonal influenza in the Netherlands over the period 2005–2007.MethodsThe Netherlands population and age group distribution for 2006 defined the base population. The number of influenza‐like illness (ILI) cases was estimated from sentinel surveillance data and adjusted for underascertainment using the estimated proportion of ILI cases that do not consult a general practitioner. The estimated number of symptomatic influenza (SI) cases was based on indirect evidence from the surveillance of ILI cases and the proportions of laboratory‐confirmed influenza cases in the 2004/5, 2005/6 and 2006/7 respiratory years. In scenario analysis, the number of SI cases prevented by increasing vaccination uptake within the 65 + age group was estimated.ResultsThe overall symptomatic infection attack rate (SIAR) over the period 2005–2007 was estimated at 2·5% (95% credible interval [CI]: 2·1–3·2%); 410 200 SI cases (95% CI: 338 500–518 600) were estimated to occur annually. Age‐group‐specific SIARs were estimated for <5 years at 4·9% (2·1–13·7%), for 5–14 years at 3·0% (2·0–4·7%), for 15–44 years at 2·6% (2·1–3·2%), for 45–64 years at 1·9% (1·4–2·5%) and for 65 + years at 1·7% (1·0–3·0%). Under assumed vaccination uptake increases of 5% and 15%, 1970 and 5310 SI cases would be averted.ConclusionsBy synthesising the available information on seasonal influenza and ILI from diverse sources, the annual extent of symptomatic infection can be derived. These estimates are useful for assessing the burden of seasonal influenza and for guiding vaccination policy.
Detection of enterovirus 68 in serum from pediatric patients with pneumonia and their clinical outcomes
Authors: Imamura Tadatsugu , Suzuki Akira , Lupisan Socorro , Kamigaki Taro , Okamoto Michiko , Roy Chandra Nath , Olveda Remigio , Oshitani Hitoshi 
Published: November 2013

Enterovirus 68 (EV68) infection occasionally manifests with fatal outcomes. However, detection of EV68 in serum and its clinical outcomes are yet to be determined. In this study, we retrospectively tested stored serum samples collected from pediatric pneumonia patients whose nasopharyngeal specimens were positive for EV68. Of total 28 nasopharyngeal sample‐positive patients, EV68 was detected in serum samples among 12 (43%) patients aged between 1 and 4 years. Our results suggest that EV68 can cause viremia by which the virus may exhibit systemic manifestations.