bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-dependent changes in the ratio of (R)- and (S)-2-butanol released by virgin females of Dasylepida ishigakiensis (Coleoptera: Scarabaeidae)
Authors: Fujiwara-Tsujii N. , Yasui H. , Wakamura S. , Mochizuki F. , Arakaki N. 
Published: November 2012

AbstractThe females of the white grub beetle, Dasylepida ishigakiensis, release two enantiomers of 2-butanol, (R)-2-butanol and (S)-2-butanol. The ratio describing the relative proportions of these two enantiomers (R/S ratio) has not yet been investigated. (R)-2-Butanol has been shown to attract males in laboratory and field experiments, whereas (S)-2-butanol tends to inhibit them. To determine the R/S ratio of the 2-butanol emitted by virgin females, we collected 2-butanol from young (53 days old), mature (63 days old) and old females (73 days old) using water, extracted with an SPME fibre and subsequently injected into GC-MS. The major component of the 2-butanol emitted by the young females was (R)-2-butanol, but as the females aged, the component ratio favoured (S)-2-butanol. Young females released an 80:20 mixture of (R)- and (S)-2-butanol, whereas old females released a 45:55 mixture. The EAG response of male antennae to a 50:50 ratio (racemic mixture) showed a similar dose-response curve to that of (R)-2-butanol. The male orientation responses to (R)-2-butanol decreased when the relative proportion of (S)-2-butanol increased. An inhibitory and/or masking effect of (S)-2-butanol on male orientation behaviour was also observed in the flight tunnel assay. These results suggest that males are more strongly attracted to young females than to old females. We also discuss the possibility of using 2-butanol isomers as a control or monitoring agent for this insect.
‘Time-Sense’: Railways and Temporality in Colonial India
Authors: PRASAD RITIKA 
Published: November 2012

AbstractThis paper traces the establishment of standardized railway time in colonial India between 1854 and 1905, and explores how the colonized—as passengers and population—negotiated the temporal re-structuring introduced through railways. Millions were affected by the process through which the time of a single meridian was selected as an all-India railway time, and gradually deemed civil time, continuing even today as Indian Standard Time. The paper explores everyday responses to this dramatic change in ‘time-sense’ engendered through railways, both as speedy transport and as standardized time. This allows for a historical analysis of how individuals and societies deal in practice with abstract technological transformations, and of how colonized populations have navigated the modernizing intervention of imperialist states. It argues that the ways in which the population of colonial India accepted, contested, and appropriated the temporal standardization instituted through railways and railway time challenged imperial policies determined by reified presumptions of metropolitan versus colonial ‘time-sense’. Since these responses were often analogous to how people and societies across the globe were responding to temporal standardization, they disrupt imperial strategies that used time-sense to locate colonized populations outside of History, in effect excluding them from their own present. They thus serve to materially de-stabilize a narrative of colonial time-lag and to reclaim the historical present as a time in which the colonizer and colonized exist contemporaneously. Consequently, they reconfigure modernity as an experiential rather than as a normative historical present.
Revisiting prehistoric sites in the Göksu valley: a GIS and social network approach
Authors: Bikoulis Peter 
Published: November 2012

AbstractUsing a variety of quantitative approaches, interactions between prehistoric sites in the Göksu valley and south-central Anatolia are modelled within their wider multi-regional and diachronic socio-economic networks to assess the prominence and influence of communities in south-central Anatolia from the Late Chalcolithic to the end of the Early Bronze Age (c. 4200–2000 BC). Since the 1950s, some have understood the valley as significant in terms of movement and communication through the Taurus mountain chain that divides the southern Anatolian plateau from the Mediterranean coast. This view is called in to question through the application of geospatial and computational methods, namely least cost pathway and social network analyses. Archaeologists use least cost pathway analysis to model movement in the past. Similarly, social network analysis is used to model contact and interaction in the past. The approach adopted in this paper seeks to combine the two methods to investigate social structure and the nature of interaction in late prehistoric south-central Anatolia. The results suggest that views of the Göksu valley as the primary or a prominent means of connecting the southern Anatolian plateau and the Mediterranean coast may need to be reassessed.
The house of Tarkondimotos: a late Hellenistic dynasty between Rome and the East
Authors: Wright Nicholas L. 
Published: November 2012

AbstractDespite its regional hegemony over eastern Kilikia and a prominent role in three Roman civil wars, the house of Tarkondimotos has maintained little more than a shadowy existence on the fringe of historical accounts of the first centuries BC to AD. This paper collates the biographical and relational data of all known or conjectured members of the Tarkondimotid dynasty and its court, and places them within a historical context.
A monument of early Byzantine Sardis: architectural analysis and graphic reconstruction of Building D
Authors: Karydis Nikolaos D. 
Published: November 2012

AbstractSardis constituted a major urban centre during the early Byzantine period, an era marked by the gradual transformation of the city into a Christian metropolis. From the fourth to the sixth century AD, Sardis maintained an important commercial, industrial and administrative role that sustained high-quality monumental construction. Yet, the major architectural types that emerged during this crucial period in the centre of the early Christian city are largely unknown to us. The unexcavated remains of the monument known as ‘Building D’ offer the best opportunity to shed light on this enigmatic aspect of the history of the city. Indeed, these remains display a late fourth century reused inscription as well as construction details typical of the early Byzantine period. They also lie in what must have been a central area of the city during this time. At first sight, this building seems hopelessly dilapidated and largely inaccessible. Still, the current paper demonstrates that a closer examination of the fabric of Building D reveals invaluable clues for its original form and function. This new exploration of the building includes the graphic recording, careful analysis and interpretation of the remains, thus providing the evidence required for the first substantiated reconstruction of a major part of the monument. The exploration reveals the articulation and structure of the primary load-bearing elements, as well as the form of the enormous vaulted canopy that covered one of the most imposing and towering spaces of early Byzantine Sardis. The article uses this reconstruction as a basis for the identification of those architectural features that help to interpret the function of the building, its role in the development of late antique Sardis as well as its position in the evolution of early Byzantine architecture in western Asia Minor.
Comparison of prevalence estimation ofMycobacterium aviumsubsp.paratuberculosisinfection by sampling slaughtered cattle with macroscopic lesionsvs.systematic sampling
Authors: ELZE J. , LIEBLER-TENORIO E. , ZILLER M. , KÖHLER H. 
Published: November 2012

SUMMARYThe objective of this study was to identify the most reliable approach for prevalence estimation ofMycobacterium aviumssp.paratuberculosis(MAP) infection in clinically healthy slaughtered cattle. Sampling of macroscopically suspect tissue was compared to systematic sampling. Specimens of ileum, jejunum, mesenteric and caecal lymph nodes were examined for MAP infection using bacterial microscopy, culture, histopathology and immunohistochemistry. MAP was found most frequently in caecal lymph nodes, but sampling more tissues optimized the detection rate. Examination by culture was most efficient while combination with histopathology increased the detection rate slightly. MAP was detected in 49/50 animals with macroscopic lesions representing 1·35% of the slaughtered cattle examined. Of 150 systematically sampled macroscopically non-suspect cows, 28·7% were infected with MAP. This indicates that the majority of MAP-positive cattle are slaughtered without evidence of macroscopic lesions and before clinical signs occur. For reliable prevalence estimation of MAP infection in slaughtered cattle, systematic random sampling is essential.
Adopting and implementing nutrition guidelines in recreational facilities: tensions between public health and corporate profitability
Authors: Olstad Dana Lee , Raine Kim D , McCargar Linda J 
Published: November 2012

AbstractObjectiveLittle is known about how public entities can partner with industry to achieve public health goals. We investigated industry's perspective of factors that influenced their adoption and implementation of voluntary, government-issued nutrition guidelines (Alberta Nutrition Guidelines for Children and Youth, ANGCY) in recreational facilities.DesignIn-depth semi-structured interviews were conducted. Data were analysed using directed content analysis.SettingFood services in recreational facilities.SubjectsSeven managers from industry participated; five from companies that had adopted and implemented the ANGCY (adopters) in recreational facilities and two from companies that had not (non-adopters).ResultsIndustry views nutrition guidelines through the lens of profitability. Non-adopters were unwilling to implement the ANGCY for fear of sacrificing short-term profitability, whereas adopters adhered to them in an attempt to position themselves for long-term profitability. Adopters faced barriers including few resources, no training, complex guidelines, low availability of and demand for ANGCY-compliant products, competitive pressures and substantial declines in revenue. Managers believed widespread voluntary adoption of the ANGCY was unlikely without government incentives and/or a mandate, as the environmental context for voluntary action was poor. All managers supported government-mandated implementation of the ANGCY to level the playing field upon which companies compete.ConclusionsPublic–private partnerships in recreational facilities can embrace public health goals in the short term, provided industry perceives potential for long-term financial gain. Widespread uptake of voluntary nutrition guidelines in this setting is unlikely, however, as market mechanisms do not encourage industry to sell and promote healthier options. Government legislation may therefore be warranted.
Correlation between the Grain Orientation Dependence of Color Etching and Chemical Etching
Authors: Bonyár Attila , Szabó Peter J. 
Published: November 2012

AbstractA gray cast iron specimen was investigated by color and chemical etching with optical and atomic force microscopy, and the effect of grain orientation on the effectiveness of etching was examined. It was proven that the grain orientation dependence of chemical and color etching is just the opposite, and that the specimen surface after color etching is not uniformly smooth. Explanation for the layer structure of the color etched iron specimen is given.
Temporal variations of geyser water chemistry in the Upper Geyser Basin, Yellowstone National Park, USA
Authors: Hurwitz Shaul , Hunt Andrew G. , Evans William C. 
Published: November 2012

Geysers are rare features that reflect a delicate balance between an abundant supply of water and heat and a unique geometry of fractures and porous rocks. Between April 2007 and September 2008, we sampled Old Faithful, Daisy, Grand, Oblong, and Aurum geysers in Yellowstone National Park's Upper Geyser Basin and characterized temporal variations in major element chemistry and water isotopes (δ18O, δD, 3H). We compare these temporal variations with temporal trends of Geyser Eruption Intervals (GEI). SiO2 concentrations and geothermometry indicate that the geysers are fed by waters ascending from a reservoir with temperatures of ∼190 to 210°C. The studied geysers display small and complex chemical and isotopic seasonal variations, and geysers with smaller volume display larger seasonal variations than geysers with larger volumes. Aurum and Oblong Geysers contain detectable tritium concentrations, suggesting that erupted water contains some modern meteoric water. We propose that seasonal GEI variations result from varying degrees of evaporation, meteoric water recharge, water table fluctuations, and possible hydraulic interaction with the adjacent Firehole River. We demonstrate that the concentrations of major dissolved species in Old Faithful Geyser have remained nearly constant since 1884 despite large changes in Old Faithful's eruption intervals, suggesting that no major changes have occurred in the hydrothermal system of the Upper Geyser Basin for >120 years. Our data set provides a baseline for monitoring future changes in geyser activity that might result from varying climate, earthquakes, and changes in heat flow from the underlying magmatic system.
Rapid purification of ribosomal particles assembled on histone H4 mRNA: a new method based on mRNA–DNA chimaeras
Authors: Prongidi-Fix Lydia , Schaeffer Laure , Simonetti Angelita , Barends Sharief , Ménétret Jean-François , Klaholz Bruno P. , Eriani Gilbert , Martin Franck 
Published: November 2012

Detailed knowledge of the structure of the ribosomal particles during their assembly on mRNA is a prerequisite for understanding the intricate translation initiation process. In vitro preparation of eukaryotic translation initiation complexes is limited by the rather tricky assembly from individually purified ribosomal subunits, initiation factors and initiator tRNA. In order to directly isolate functional complexes from living cells, methods based on affinity tags have been developed which, however, often suffer from non-specific binding of proteins and/or RNAs. In the present study we present a novel method designed for the purification of high-quality ribosome/mRNA particles assembled in RRL (rabbit reticulocyte lysate). Chimaerical mRNA–DNA molecules, consisting of the full-length mRNA ligated to a biotinylated desoxy-oligonucleotide, are immobilized on streptavidin-coated beads and incubated with RRL to form initiation complexes. After a washing step, the complexes are eluted by specific DNase I digestion of the DNA moiety of the chimaera, releasing initiation complexes in native conditions. Using this simple and robust purification setup, 80S particles properly programmed with full-length histone H4 mRNA were isolated with the expected ribosome/mRNA molar ratio of close to 1. We show that by using this novel approach purified ribosomal particles can be obtained that are suitable for biochemical and structural studies, in particular single-particle cryo-EM (cryo-electron microscopy). This purification method thus is a versatile tool for the isolation of fully functional RNA-binding proteins and macromolecular RNPs.
Eating disorders in athletes: Overview of prevalence, risk factors and recommendations for prevention and treatment
Authors: Bratland‐Sanda Solfrid , Sundgot‐Borgen Jorunn 
Published: November 2012

AbstractThe prevalence of disordered eating and eating disorders vary from 0–19% in male athletes and 6–45% in female athletes. The objective of this paper is to present an overview of eating disorders in adolescent and adult athletes including: (1) prevalence data; (2) suggested sport‐ and gender‐specific risk factors and (3) importance of early detection, management and prevention of eating disorders. Additionally, this paper presents suggestions for future research which includes: (1) the need for knowledge regarding possible gender‐specific risk factors and sport‐ and gender‐specific prevention programmes for eating disorders in sports; (2) suggestions for long‐term follow‐up for female and male athletes with eating disorders and (3) exploration of a possible male athlete triad.
Long‐term outcome of phenobarbital treatment for epilepsy in rural China: A prospective cohort study
Authors: Kwan Patrick , Wang Wenzhi , Wu Jianzhong , Li Shichuo , Yang Hongchao , Ding Ding , Hong Zhen , Dai Xiuying , Yang Bing , Wang Taiping , Yuan Chenglin , Ma Guangyu , de Boer Hanneke M. , Sander Josemir W. 
Published: November 2012

SummaryPurpose:  To evaluate the long‐term outcome of phenobarbital treatment for convulsive epilepsy in rural China, and to explore factors associated with overall seizure outcomes.Methods:  We carried out follow‐up assessments of people who took part in an epilepsy community management program conducted in rural counties of six provinces in China. People with convulsive epilepsy who were previously untreated (or on irregular treatment) were commenced on regular treatment with phenobarbital. Information was collected using a standardized questionnaire by face‐to‐face interviews of the individuals (and their families where necessary). Information collected included treatment status, medication change, seizure frequency, and mortality.Key Findings:  Among the 2,455 people who participated in the original program, outcomes were successfully ascertained during the follow‐up assessment in 1986. Among them, 206 had died. Information on treatment response was obtained in 1,780 (56% male; mean age 33.9 years, range 3–84; mean duration of follow‐up 6.4 years). Among them, 939 (53%) were still taking phenobarbital. The most common reasons for stopping phenobarbital were seizure freedom or substantial seizure reduction, socioeconomic reasons, and personal preference. Four hundred fifty‐three individuals (25%) became seizure‐free for at least 1 year while taking phenobarbital, 88% of whom did so at daily doses of 120 mg or below. Four hundred six (23%) reported adverse events, which led to withdrawal of phenobarbital in <1%. The most common adverse effects were malaise/somnolence (7.4%), dizziness (3%), and lethargy (2.6%). At the follow‐up assessment, 688 (39%) individuals had been seizure free for at least the previous year. People with persistent seizures had significantly longer duration of epilepsy and higher number of seizures in the 12 months before treatment. People who were taking AED treatment irregularly at recruitment were less likely to become seizure‐free.Significance:  We observed long‐term benefits of regular treatment with phenobarbital for convulsive epilepsy in rural China. One hundred years after the discovery of its antiepileptic effect, phenobarbital is still playing an important role in the management of epilepsy.
Christ For Us Today – Promeity in the Christologies of Bonhoeffer and Kierkegaard
Authors: Ziegler Philip 
Published: November 2012

AbstractIn 1944, Bonhoeffer famously asked ‘Who is Christ really, for us today?’ This question is ambiguous: ‘Christ for us’ points to an objective claim concerning the personal identity of Christ, while ‘for us today’ signals the need for ever new subjective value judgements and contextual appropriations. Does emphasis upon the promeity of Christ, like that found in the work of Bonhoeffer, volatilize the identity of Christ? Examination of the theme of promeity in the work of Bonhoeffer himself, as well as that of Kierkegaard, demonstrates that in the hands of both these Lutheran theologians promeity is acknowledged to be intrinsic to the fides quae creditur. The subjective appropriation and contextual character of Christology then proves to be a function of a prior and more decisive reality, namely the very identity of God in Christ for us.
Nationalism and war commemoration – a Latin American exceptionalism?
Authors: Vom Hau Matthias 
Published: November 2012

AbstractRecent scholarship on collective memory and nationalism in Latin America argues that – in sharp contrast to Europe – war commemoration has been of little importance to the memory work of states in the region. The article challenges this claim. A comparative‐historical analysis of school textbooks and school ceremonies in twentieth‐century Mexico, Argentina and Peru reveals that the commemoration of major civil and international wars was central to official national narratives in these countries. The article further identifies important qualitative changes in war commemoration over time, especially with respect to how commemorative discourses portrayed agency and assigned responsibility for military victories and losses. These changes are situated within broader transformations of nationalism and new alignments in the politics of nationhood and memory.
Volatile isoprenoid emissions from plastid to planet
Authors: Harrison Sandy P. , Morfopoulos Catherine , Dani K. G. Srikanta , Prentice I. Colin , Arneth Almut , Atwell Brian J. , Barkley Michael P. , Leishman Michelle R. , Loreto Francesco , Medlyn Belinda E. , Niinemets Ülo , Possell Malcolm , Peñuelas Josep , Wright Ian J. 
Published: November 2012

SummaryApproximately 1–2% of net primary production by land plants is re‐emitted to the atmosphere as isoprene and monoterpenes. These emissions play major roles in atmospheric chemistry and air pollution–climate interactions. Phenomenological models have been developed to predict their emission rates, but limited understanding of the function and regulation of these emissions has led to large uncertainties in model projections of air quality and greenhouse gas concentrations. We synthesize recent advances in diverse fields, from cell physiology to atmospheric remote sensing, and use this information to propose a simple conceptual model of volatile isoprenoid emission based on regulation of metabolism in the chloroplast. This may provide a robust foundation for scaling up emissions from the cellular to the global scale.
Case-Control Study of Drug Monitoring of β-Lactams in Obese Critically Ill Patients
Authors: Hites Maya , Taccone Fabio Silvio , Wolff Fleur , Cotton Frédéric , Beumier Marjorie , De Backer Daniel , Roisin Sandrine , Lorent Sophie , Surin Rudy , Seyler Lucie , Vincent Jean-Louis , Jacobs Frédérique 
Published: November 2012

ABSTRACT

Severe sepsis and septic shock can alter the pharmacokinetics of broad-spectrum β-lactams (meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate serum concentrations. Obesity may further modify the pharmacokinetics of these agents. We reviewed our data on critically ill obese patients (body mass index of ≥30 kg/m
2
) treated with a broad-spectrum β-lactam in whom therapeutic drug monitoring was performed and compared the data to those obtained in critically nonobese patients (body mass index of <25 kg/m
2
) to assess whether there were differences in reaching optimal drug concentrations for the treatment of nosocomial infections. Sixty-eight serum levels were obtained from 49 obese patients. There was considerable variability in β-lactam serum concentrations (coefficient of variation of 50% to 92% for the three drugs). Standard drug regimens of β-lactams resulted in insufficient serum concentrations in 32% of the patients and overdosed concentrations in 25%. Continuous renal replacement therapy was identified by multivariable analysis as a risk factor for overdosage and a protective factor for insufficient β-lactam serum concentrations. The serum drug levels from the obese cohort were well matched for age, gender, renal function, and sequential organ failure assessment (SOFA) score to 68 serum levels measured in 59 nonobese patients. The only difference observed between the two cohorts was in the subgroup of patients treated with meropenem and who were not receiving continuous renal replacement therapy: serum concentrations were lower in the obese cohort. No differences were observed in pharmacokinetic variables between the two groups. Routine therapeutic drug monitoring of β-lactams should be continued in obese critically ill patients.