bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing youth internalizing symptoms: Effects of a family-based preventive intervention on parental guilt induction and youth cognitive style
Authors: McKee Laura G. , Parent Justin , Forehand Rex , Rakow Aaron , Watson Kelly H. , Dunbar Jennifer P. , Reising Michelle M. , Hardcastle Emily , Compas Bruce E. 
Published: January 2014

AbstractThis study utilized structural equation modeling to examine the associations among parental guilt induction (a form of psychological control), youth cognitive style, and youth internalizing symptoms, with parents and youth participating in a randomized controlled trial of a family-based group cognitive–behavioral preventive intervention targeting families with a history of caregiver depression. The authors present separate models utilizing parent report and youth report of internalizing symptoms. Findings suggest that families in the active condition (family-based group cognitive–behavioral group) relative to the comparison condition showed a significant decline in parent use of guilt induction at the conclusion of the intervention (6 months postbaseline). Furthermore, reductions in parental guilt induction at 6 months were associated with significantly lower levels of youth negative cognitive style at 12 months. Finally, reductions in parental use of guilt induction were associated with lower youth internalizing symptoms 1 year following the conclusion of the intervention (18 months postbaseline).
Sémantique temporelle et accord du participe passé en français parlé: une analyse variationniste
Authors: GAUCHER DAMIEN 
Published: January 2014

RÉSUMÉDans cet article, nous analysons l'influence de la valeur aspectuo-temporelle attribuée aux formes composées sur la fréquence d’accord du participe passé (APP). On sait que l'APP est variable dans les usages de la langue parlée, notamment lorsqu’il est employé avec l'auxiliaireavoir. Partant de l'observation de corpus de langue parlée, et d’une approche variationniste, nous évaluons la fréquence d’accord des participes féminins potentiellement audibles, en fonction de l'effet de sens qui est attribué à la séquence [avoir(pres) + PP], selon qu’il est évalué comme ‘résultant’ ou ‘événementiel’ selon la terminologie de Desclés et Guentcheva (2003). Les résultats de cette analyse laissent entrevoir une influence faible mais relativement constante de ce facteur sémantique sur l'APP, et soulèvent plus avant la question de la présence d’éléments spécifiques au médium oral comme facteurs d’influence sur le marquage morphologique du genre; en d’autres termes, de l'existence d’une grammaire spontanée de l'oral (Branca-Rosoff, 2005).
Cette mesure est-elle vraiment clé? A constructional approach to categorial gradience
Authors: VAN GOETHEM KRISTEL 
Published: January 2014

ABSTRACTThis article investigates the recently developed adjectival properties of the French noun clé ‘key’, as attested in for instance un poste très clé ‘a really key position’ and Cette mesure est-elle vraiment clé? ‘Is this measure really key?’. The main purpose of this study is triple: it consists in analysing (i) which adjectival uses can be found in modern French, (ii) to what extent they are accepted by native speakers (from different geographical varieties) of French, and (iii) how they can be accounted for within the framework of Construction Grammar and Construction Morphology. It will be hypothesised that French clé is subject to categorial gradience as a consequence of an ongoing constructionalisation process.
Native and non-native perceptions of appropriateness in the French second-person pronoun system
Authors: VAN COMPERNOLLE RÉMI A. 
Published: January 2014

ABSTRACTThis article explores perceptions of appropriateness in the French second-person pronoun system in relation to various sociopragmatic factors among native and nonnative speakers of French between the ages of 18 and 29. Participants completed an online survey in which a series of five social-interactive situations were presented. Analysis focused on the similarities and differences among native, near-native, advanced and intermediate speakers in their perceptions of formality, social distance, power/equality and appropriatetu/voususe, as well as correlations between the sociopragmatic factors and selection oftuorvous. Results indicate a high degree of variation within and across participant groups, with nonnatives tending to be more conservative (e.g., more formality, higher frequencies ofvous) in their choices than their native-speaker counterparts. In concluding, the findings are discussed in relation to pedagogical implications.
Nigra crux mala crux: a comparative perspective on urban conflict in Gdansk in 1411 and 1416
Authors: HESS CORDELIA 
Published: January 2014

ABSTRACTBetween 1411 and 1416, Gdansk was the scene for a complex conflict between town population, council and landlord, eventually resulting in violent riots. The peculiar character of these riots becomes apparent when the Gdansk chronicles are compared to the historical accounts from other, better-known conflicts, particularly sources depicting the LübeckKnochenhauerrebellion, the Hamburg brewer's rebellion of 1481 and the 1449–53Gentse opstand. A key difference is the extent to which chroniclers understood and portrayed the ritualized action that occurred in the urban uprisings. Comparing the contemporary chronicles of the Gdansk events with the town's urban historiography 100 years later also shows that this early conflict with the landlord later played a significant role in urban self-definition.
Post Melody valve implant in a conduit with regurgitant native outflow tract successful closure by Amplatzer muscular device
Authors: Momenah Tarek S. , El Houry Motea T. , Khan Muhammad A. , Galal Mohammed O. 
Published: January 2014

AbstractWe describe the technique of closure of native right ventricular outflow tract by Amplatzer muscular ventricular septal defect device because of severe regurgitation in a patient who had tetralogy of Fallot repair with conduit at 3 years of age followed by percutaneous Melody valve implant 6 years later.
Hypoplastic left heart with intact atrial septum and levoatriocardinal vein: a challenge in identifying aortic arch branches
Authors: Paudel Govinda , Ng Benton Y. , Law Ian H. 
Published: January 2014

AbstractThe levoatriocardinal vein provides alternative egress from the left atrium to the systemic veins in left-sided obstructive lesions. Although rare, it has been described in association with hypoplastic left heart syndrome. We report a case of hypoplastic left heart syndrome with levoatriocardinal vein and aberrant right subclavian artery where cardiac magnetic resonance imaging/angiography proved to be a valuable imaging modality for pre-operative evaluation.
The effect of age on portfolio choices: evidence from an Italian pension fund
Authors: CAPPELLETTI GIUSEPPE , GUAZZAROTTI GIOVANNI , TOMMASINO PIETRO 
Published: January 2014

AbstractAccording to optimal portfolio theories, investors should reduce their exposure to stock market risk as they grow old. Indeed, older workers, with only a few years left before retirement, are particularly vulnerable to unexpected falls in stock prices. Despite the theoretical and – as shown by the recent financial crisis – policy relevance of the issue, empirical evidence on this topic has been scant and inconclusive. The aim of the present paper is to assess the effect of age on portfolio choices, using a new panel dataset from an Italian defined-contribution pension plan. We find that on average holdings of risky assets do indeed significantly decrease with age. However, the effect is non-linear, being much stronger in the last part of one's career. Moreover, we also document that inertial behaviour is quite widespread, and can be very costly. Results are confirmed when we control for individual fixed effects and cohort effects.
In situ study of defect migration kinetics in nanoporous Ag with enhanced radiation tolerance
Authors: Sun C. , Bufford D. , Chen Y. , Kirk M. A. , Wang Y. Q. , Li M. , Wang H. , Maloy S. A. , Zhang X. 
Published: January 2014

AbstractDefect sinks, such as grain boundaries and phase boundaries, have been widely accepted to improve the irradiation resistance of metallic materials. However, free surface, an ideal defect sink, has received little attention in bulk materials as surface-to-volume ratio is typically low. Here by using in situ Kr ion irradiation technique in a transmission electron microscope, we show that nanoporous (NP) Ag has enhanced radiation tolerance. Besides direct evidence of free surface induced frequent removal of various types of defect clusters, we determined, for the first time, the global and instantaneous diffusivity of defect clusters in both coarse-grained (CG) and NP Ag. Opposite to conventional wisdom, both types of diffusivities are lower in NP Ag. Such a surprise is largely related to the reduced interaction energy between isolated defect clusters in NP Ag. Determination of kinetics of defect clusters is essential to understand and model their migration and clustering in irradiated materials.
Chemical signatures and new drug targets for gametocytocidal drug development
Authors: Sun Wei , Tanaka Takeshi Q. , Magle Crystal T. , Huang Wenwei , Southall Noel , Huang Ruili , Dehdashti Seameen J. , McKew John C. , Williamson Kim C. , Zheng Wei 
Published: January 2014

AbstractControl of parasite transmission is critical for the eradication of malaria. However, most antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria. Consequently, patients can remain infectious for weeks after the clearance of asexual parasites and clinical symptoms. Here we report the identification of 27 potent gametocytocidal compounds (IC50 < 1 μM) from screening 5,215 known drugs and compounds. All these compounds were active against three strains of gametocytes with different drug sensitivities and geographical origins, 3D7, HB3 and Dd2. Cheminformatic analysis revealed chemical signatures for P. falciparum sexual and asexual stages indicative of druggability and suggesting potential targets. Torin 2, a top lead compound (IC50 = 8 nM against gametocytes in vitro), completely blocked oocyst formation in a mouse model of transmission. These results provide critical new leads and potential targets to expand the repertoire of malaria transmission-blocking reagents.
Mature VLDL triggers the biogenesis of a distinct vesicle from the trans-Golgi network for its export to the plasma membrane
Authors: Hossain Tanvir , Riad Aladdin , Siddiqi Shaila , Parthasarathy Sampath , Siddiqi Shadab A. 
Published: January 2014

Post-Golgi trafficking of mature VLDL (very-low-density lipoprotein) is crucial in maintaining normal TAG (triacylglycerol) homoeostasis of hepatocytes; however, the mechanism that regulates the exit of mature VLDL from the TGN (trans-Golgi network) is not known. We developed an in vitro TGN-budding assay that allowed us to examine the formation of secretory vesicles from the TGN in primary rat hepatocytes. We isolated TAG-rich PG-VTVs (post-TGN VLDL transport vesicles) using a continuous sucrose density gradient. PG-VTVs were distributed in low-density fractions, whereas protein transport vesicles were present in relatively higher-density fractions of the same sucrose gradient. EM revealed large intact PG-VTVs ranging 300–350 nm in size. The biogenesis of PG-VTVs from the TGN required cytosol, ATP, GTP hydrolysis and incubation at 37°C. PG-VTVs concentrated the VLDL proteins: apolipoproteins apoB100, apoAIV, apoAI and apoE, but did not contain either albumin or transferrin. Proteinase K treatment did not degrade VLDL core proteins, suggesting that PG-VTVs were sealed. PG-VTVs were able to fuse with and deliver VLDL to the PM (plasma membrane) in a vectorial manner. We conclude that we have identified a new TGN-derived vesicle, the PG-VTV, which specifically transports mature VLDL from the TGN to the PM.
A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
Authors: Pham James S. , Sakaguchi Reiko , Yeoh Lee M. , De Silva Nilushi S. , McFadden Geoffrey I. , Hou Ya-Ming , Ralph Stuart A. 
Published: January 2014

Plasmodium parasites possess two endosymbiotic organelles: a mitochondrion and a relict plastid called the apicoplast. To accommodate the translational requirements of these organelles in addition to its cytosolic translation apparatus, the parasite must maintain a supply of charged tRNA molecules in each of these compartments. In the present study we investigate how the parasite manages these translational requirements for charged tRNACys with only a single gene for CysRS (cysteinyl-tRNA synthetase). We demonstrate that the single PfCysRS (Plasmodium falciparum CysRS) transcript is alternatively spliced, and, using a combination of endogenous and heterologous tagging experiments in both P. falciparum and Toxoplasma gondii, we show that CysRS isoforms traffic to the cytosol and apicoplast. PfCysRS can recognize and charge the eukaryotic tRNACys encoded by the Plasmodium nucleus as well as the bacterial-type tRNA encoded by the apicoplast genome, albeit with a preference for the eukaryotic type cytosolic tRNA. The results of the present study indicate that apicomplexan parasites have lost their original plastidic cysteinyl-tRNA synthetase, and have replaced it with a dual-targeted eukaryotic type CysRS that recognizes plastid and nuclear tRNACys. Inhibitors of the Plasmodium dual-targeted CysRS would potentially offer a therapy capable of the desirable immediate effects on parasite growth as well as the irreversibility of inhibitors that disrupt apicoplast inheritance.
Nanowatt multi‐scale continuous wavelet transform chip
Authors: Casson A. J. , Rodriguez‐Villegas E. 
Published: January 2014

A four‐scale continuous wavelet transform filter bank implemented in a 0.18 μm CMOS process is presented. Experimental results demonstrate the real‐time multi‐scale analysis of electrocardiogram signals with a power consumption of 1.3 nW, the lowest reported power consumption for a complete wavelet filter bank. In addition, the results demonstrate for the first time the use of pico‐amp scale currents in a 0.18 μm CMOS process for providing advanced signal processing functions.
Driver fatigue and drowsiness monitoring system with embedded electrocardiogram sensor on steering wheel
Authors: Jung Sang‐Joong , Shin Heung‐Sub , Chung Wan‐Young 
Published: January 2014

Real time driver health condition monitoring system with drowsiness alertness was proposed. A new embedded electrocardiogram (ECG) sensor with electrically conductive fabric electrodes on the steering wheel of a car was designed to monitor the driver's health condition. The ECG signals were measured at a sampling rate of 100 Hz from the driver's palms as they stay on a pair of conductive fabric electrodes located on the steering wheel. Practical tests were conducted using an embedded ECG sensor with a wireless sensor node, and their performance was assessed under non‐stop 2 h driving test. The ECG signals were measured and transmitted wirelessly to a base station connected to a server PC in personal area network environment. The driver's health condition such as the normal, fatigued and drowsy states was analysed by evaluating the heart rate variability in the time and frequency domains.
A general approach to site-specific antibody drug conjugates
Authors: Tian Feng , Lu Yingchun , Manibusan Anthony , Sellers Aaron , Tran Hon , Sun Ying , Phuong Trung , Barnett Richard , Hehli Brad , Song Frank , DeGuzman Michael J. , Ensari Semsi , Pinkstaff Jason K. , Sullivan Lorraine M. , Biroc Sandra L. , Cho Ho , Schultz Peter G. , DiJoseph John , Dougher Maureen , Ma Dangshe , Dushin Russell , Leal Mauricio , Tchistiakova Lioudmila , Feyfant Eric , Gerber Hans-Peter , Sapra Puja 
Published: January 2014

Significance
Here we demonstrate the ability to genetically incorporate nonnative amino acids into proteins in mammalian cells using both transient and stable platform expression systems that provide yields and fidelities compatible with commercial applications. To illustrate the utility of this methodology we have generated chemically homogeneous antibody drug conjugates (NDCs) with precise control over the site and stoichiometry of drug conjugation. In rodent xenograft models these NDCs display improved properties, including half-life, efficacy and safety, relative to conventional heterogeneous ADCs. These advances allow the generation of therapeutic antibody drug conjugates with medicinal chemistry like control over structure, which should greatly facilitate the optimization of their pharmacological activities.
Searching for missing heritability: Designing rare variant association studies
Authors: Zuk Or , Schaffner Stephen F. , Samocha Kaitlin , Do Ron , Hechter Eliana , Kathiresan Sekar , Daly Mark J. , Neale Benjamin M. , Sunyaev Shamil R. , Lander Eric S. 
Published: January 2014

Significance
Discovering the genetic basis of common diseases, such as diabetes, heart disease, and schizophrenia, is a key goal in biomedicine. Genomic studies have revealed thousands of common genetic variants underlying disease, but these variants explain only a portion of the heritability. Rare variants are also likely to play an important role, but few examples are known thus far, and initial discovery efforts with small sample sizes have had only limited success. In this paper, we describe an analytical framework for the design of rare variant association studies of disease. It provides guidance with respect to sample size, as well as the roles of selection, disruptive and missense alleles, gene-specific allele frequency thresholds, isolated populations, gene sets, and coding vs. noncoding regions.
The biomechanics of race walking: Literature overview and new insights
Authors: Pavei Gaspare , Cazzola Dario , La Torre Antonio , Minetti Alberto E. 
Published: January 2014

AbstractThis review aims to provide both researchers and coaches with a comprehensive overview of race walking biomechanics and to point out new viable route for future analyses. The examined literature has been divided into three categories according to the method of analysis: kinematics, ground reaction forces and joint power/efficiency. From an overall view, race walking athletes seem to adhere to the ‘straightened knee’ rule, but at race speed they do not observe the ‘no‐flight time’ rule. The coach‐oriented analysis highlights that stride length (SL) is more important than stride frequency (SF) for increasing speed and it is mainly obtained by ankle and hip joint power. Moreover, kinematic differences (SF, SL and flight time) between male and female athletes were shown. Also, we found that the maximal speed prediction according to dynamic similarity theory with walking (Froude number) is not applicable as the 3D trajectory of the body centre of mass does not follow an arc of circumference as in walking. The analysed literature shows some shortcomings: (1) the data collection is often unreliable because of the mixture of gender and performance level and (2) the analysis has sometimes been performed on a limited number of strides and speeds. These limitations lead to a scattered and incomplete gait description and a biased application of the results. The research strategy adopted so far is promising but further rigorous analyses need to be approached to obtain a fully comprehensive picture of race walking and to provide coaches with consistent results and reference values.
The Impact of Aerators on Water Contamination by Emerging Gram-Negative Opportunists in At-Risk Hospital Departments
Authors: Cristina Maria Luisa , Spagnolo Anna Maria , Casini Beatrice , Baggiani Angelo , Giudice Pietro Del , Brusaferro Silvio , Poscia Andrea , Moscato Umberto , Perdelli Fernanda , Orlando Paolo 
Published: January 2014

Objective.Our aim was to evaluate the impact of aerators on water microbiological contamination in at-risk hospital departments, with a view to quantifying the possible risk of patient exposure to waterborne microorganisms.Design.We analyzed the microbiological and chemical-physical characteristics of hot and cold water in some critical hospital departments.Setting.Two hospitals in northern Italy.Methods.We took 304 water samples over a 1-year period, at 3-month intervals, from taps used by healthcare personnel for handwashing, surgical washing, and the washing of medical equipment. We analyzed heterotrophic plate counts (HPCs) at 36°C and 22°C, nonfastidious gram-negative bacteria (GNB-NE), andLegionella pneumophila.Results.The percentages of positivity and mean values of HPCs at 22°C, HPCs at 36°C, and GNB-NE loads were significantly higher at outlet points than in the plumbing system. In particular, GNB-NE positivity was higher at outlet points than in the plumbing system in both the cold water (31.58% vs 6.58% of samples were positive) and hot water (21.05% vs 3.95%) supplies. Our results also revealed contamination byL. pneumophilaboth in the plumbing system and at outlet points, with percentages of positive samples varying according to the serogroup examined (serogroups 1 and 2-14). The mean concentrations displayed statistically significant (P< .001) differences between the outlet points (27,382.89 ± 42,245.33 colony-forming units [cfu]/L) and the plumbing system (19,461.84 ± 29,982.11 cfu/L).Conclusions.These results reveal a high level of contamination of aerators by various species of gram-negative opportunists that are potentially very dangerous for immunocompromised patients and, therefore, the need to improve the management of these devices.
Generic management procedures for data-poor fisheries: forecasting with few data
Authors: Geromont H. F. , Butterworth D. S. 
Published: January 2014

Abstract
The majority of fish stocks worldwide are not managed quantitatively as they lack sufficient data, particularly a direct index of abundance, on which to base an assessment. Often these stocks are relatively “low value”, which renders dedicated scientific management too costly, and a generic solution is therefore desirable. A management procedure (MP) approach is suggested where simple harvest control rules are simulation tested to check robustness to uncertainties. The aim of this analysis is to test some very simple “off-the-shelf” MPs that could be applied to groups of data-poor stocks which share similar key characteristics in terms of status and demographic parameters. For this initial investigation, a selection of empirical MPs is simulation tested over a wide range of operating models (OMs) representing resources of medium productivity classified as severely depleted, to ascertain how well these different MPs perform. While the data-moderate MPs (based on an index of abundance) perform somewhat better than the data-limited ones (which lack such input) as would be expected, the latter nevertheless perform surprisingly well across wide ranges of uncertainty. These simple MPs could well provide the basis to develop candidate MPs to manage data-limited stocks, ensuring if not optimal, at least relatively stable sustainable future catches.