bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reductive Couplings of 2‐Halopyridines Without External Ligand: Phosphine‐Free Nickel‐Catalyzed Synthesis of Symmetrical and Unsymmetrical 2,2′‐Bipyridines.
Authors: Liao Lian‐Yan , Kong Xing‐Rui , Duan Xin‐Fang 
Published: June 2014

AbstractThe synthetic value of the present protocol is demonstrated by preparation of caerulomycin F (IXc).
ChemInform Abstract: Manganese(III) Acetate Mediated Oxidative Radical Cyclizations of N‐(2‐Alkenylaryl)‐Substituted Enamines.
Authors: Tsai Pei‐Ju , Kao Chih‐Bo , Chiow Wan‐Ru , Chuang Che‐Ping 
Published: June 2014

AbstractTwo different sets of reaction conditions are developed for the synthesis of functionalized quinolines via 6‐exo‐trig radical cyclizations of an imine radical, generated from enamine substrates.
ChemInform Abstract: A Novel Approach for C—C, C—N, and C—O Bond Formation Reactions: A Facile Synthesis of Benzophenazine, Quinoxaline, and Phenoxazine Derivatives via Ring Opening of Benzoxepines.
Authors: Raju Bhimapaka China , Prasad Kasagani Veera , Saidachary Gannerla , Sridhar Balasubramanian 
Published: June 2014

AbstractApplication of a stoichiometric amount of AcOH instead of a catalytic amount of Bi(OTf)3 affords the corresponding products in similar yields.
ChemInform Abstract: Stereoselective Capture of N‐Acyliminium Ions Generated from α‐Hydroxy‐N‐acylcarbamides: Direct Synthesis of Uracils from Barbituric Acids Enabled by SmI2 Reduction.
Authors: Szostak Michal , Sautier Brice , Procter David J. 
Published: June 2014

AbstractLewis acid promoted cleavage of α‐amino alcohols derived from barbituric acids via chemoselective Sm(II)‐mediated electron transfer affords a wide range of 5,6‐dihydrouracils.
ChemInform Abstract: Radical Route for the Alkylation of Purine Nucleosides at C6 via Minisci Reaction.
Authors: Xia Ran , Xie Ming‐Sheng , Niu Hong‐Ying , Qu Gui‐Rong , Guo Hai‐Ming 
Published: June 2014

AbstractA highly regioselective Minisci reaction for the decarboxylative alkylation of Purine derivatives under mild conditions is presented.
ChemInform Abstract: 1,5‐Rhodium Shift in Rearrangement of N‐Arenesulfonylazetidin‐3‐ols into Benzosultams.
Authors: Ishida Naoki , Shimamoto Yasuhiro , Yano Takaaki , Murakami Masahiro 
Published: June 2014

AbstractThe presented synthesis gives access to enantiopure benzosultams from the title substrates, that are synthesized from natural amino acids.
ChemInform Abstract: Ugi Three‐Component Coupling Reaction for the Synthesis of 2‐(6‐Oxo‐11‐phenyl‐7,8‐dihydrobenzo[b]pyrrolo[1,2‐d] [1,4]diazocin‐5(6H)‐yl)‐2‐phenylacetamide Derivatives.
Authors: Reddy P. Lakshmi , Ashok Kumar D. , Lakshmi Devi M. , Reddy T. Veera , Reddy B.V. Subba , Narender R. 
Published: June 2014

AbstractA three‐component, four center Ugi reaction of pyrrol derivatives (I) with aromatic aldehydes and t‐butyl isocyanide is achieved to produce a novel class of fused heterocycles.
ChemInform Abstract: Scyllo‐Inositol as a Convenient Protecting Group for Aryl Boronic Acids in Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Kuno Shinichi , Kimura Tomoyuki , Yamaguchi Masanori 
Published: June 2014

AbstractScyllo‐inositol forms air‐ and water‐stable borate complexes with aryl boronic acids.
ChemInform Abstract: Formal Carbon Insertion of N‐Tosylhydrazone into B—B and B—Si Bonds: gem‐Diborylation and gem‐Silylborylation of sp3 Carbon.
Authors: Li Huan , Shangguan Xianghang , Zhang Zhikun , Huang Shan , Zhang Yan , Wang Jianbo 
Published: June 2014

AbstractA convenient method is developed to synthesize 1,1‐diboronates from the corresponding N‐tosylhydrazones which are easily obtained by reaction of the carbonyl compounds with tosylhydrazine.
ChemInform Abstract: Phosphinite‐Iminopyridine Iron Catalysts for Chemoselective Alkene Hydrosilylation.
Authors: Peng Dongjie , Zhang Yanlu , Du Xiaoyong , Zhang Lei , Leng Xuebing , Walter Marc D. , Huang Zheng 
Published: June 2014

AbstractThe title catalysts are efficient and selective for the anti‐Markovnikov alkene hydrosilylation of primary, secondary, and tertiary silanes.
ChemInform Abstract: A New Spiroindene Pigment from the Medicinal Fungus Phellinus ribis.
Authors: Kubo Miwa , Liu Yuhong , Ishida Mami , Harada Kenichi , Fukuyama Yoshiyasu 
Published: June 2014

AbstractA new spiroindene pigment, phelliribsin A (I), is isolated along with the known yellow pigment phelligridin F and inoscavin B from the medicinal fungus Phellinus ribis.
ChemInform Abstract: Bioinspired Total Synthesis of (.+‐.)‐Yezo′otogirin C (I).
Authors: He Shuzhong , Yang Wei , Zhu Lizhi , Du Guangyan , Lee Chi‐Sing 
Published: June 2014

AbstractThe total synthesis of the title compound is achieved from 3‐methyl‐4‐prenylcyclohex‐2‐one in eight steps with 23% overall yield without the need of protecting groups, for the first time.
ChemInform Abstract: Modular Synthesis of Lamellarins [cf. (XII)] via Regioselective Assembly of 3,4,5‐Differentially Arylated Pyrrole‐2‐carboxylates (XI).
Authors: Komatsubara Masashi , Umeki Teppei , Fukuda Tsutomu , Iwao Masatomo 
Published: June 2014

AbstractThe new methodology uses monomethoxycarbonylation of 2,5‐dibromopyrrole (I) followed by Pd‐catalyzed iterative Suzuki—Miyaura coupling reactions of the pyrrole core as key steps.
ChemInform Abstract: Myrifabine (I), the First Dimeric Myrioneuron Alkaloid from Myrioneuron faberi
Authors: Cao Ming‐Ming , Huang Sheng‐Dian , Di Ying‐Tong , Yuan Chun‐Mao , Zuo Guo‐Ying , Gu Yu‐Cheng , Zhang Yu , Hao Xiao‐Jiang 
Published: June 2014

Abstractisolation and structure elucidation
ChemInform Abstract: Ruthmycin, a New Tetracyclic Polyketide from Streptomyces sp. RM‐4‐15.
Authors: Thorson Jon S. , et al. et al. 
Published: June 2014

AbstractRuthmycin is screened for its′ in vitro antibacterial, anticancer, and antifungal activity and displays moderate antifungal activity.
ChemInform Abstract: Efficient Total Synthesis and Biological Activities of 6‐Deoxyisojacareubin.
Authors: Dai Ming , Yuan Xing , Zhu Zhi‐Jun , Shan Lei , Liu Run‐Hui , Sun Qing‐Yan , Zhang Wei‐Dong 
Published: June 2014

Abstract6‐Deoxyisojacareubin (I) is prepared via a six‐step route with an overall yield of about 20%.
Postoperative serum methylation levels of TAC1 and SEPT9 are independent predictors of recurrence and survival of patients with colorectal cancer
Authors: Tham CheeKian , Chew MinHoe , Soong Richie , Lim JitFong , Ang MeiKim , Tang ChoongLeong , Zhao Yi , Ong Simon Y. K. , Liu Yanqun 
Published: June 2014

BACKGROUNDSerum carcinoembryonic antigen (CEA) is the only marker recommended for surveillance of colorectal cancer (CRC) recurrence; its sensitivity and specificity, however, are suboptimal. This study sought to evaluate the values of postoperative serum methylation levels of 7 genes for prognostication and especially for recurrence detection after curative resection.METHODSThis prospective cohort study included 150 patients with stage I‐III CRC from whom 3 consecutive blood sampling was taken 1 week before, and 6 months and 1 year after operation. Methylation levels of 7 genes were evaluated via quantitative methylation‐specific polymerase chain reaction. Serum CEA was measured in parallel. Univariate and multivariate survival analyses were followed by construction of receiver operating characteristic curves for recurrence detection.RESULTSAfter a median follow‐up of 59 months, 43 patients (28.7%) developed recurrent lesions. High serum methylation levels of TAC1 in serum at 6‐month follow‐up (6M‐FU), and SEPT9 at 1‐year follow‐up (1Y‐FU) were independent predictors for tumor recurrence and unfavorable cancer‐specific survival (CSS) (P < .05 in all tests). Serum NELL1 methylation levels were significant alone for CSS at both 6M‐FU and 1Y‐FU, but not for disease‐free survival. Dynamic changes of TAC1 and SEPT9 with methylation increment were also independently predictive for recurrence (P < .05 in all tests). More importantly, TAC1 at 6M‐FU and SEPT9 at 1Y‐FU exhibited earlier detection of potential recurrences compared with concurrent serum CEA.CONCLUSIONSLevels of TAC1 and SEPT9 methylation detected in postoperative sera of patients with CRC appear to be novel promising prognostic markers and may probably be considered for monitoring of CRC recurrence. Cancer 2014;120:3131–3141. © 2014 American Cancer Society.
The effects of the nonselective benzodiazepine lorazepam and the α2/α3 subunit‐selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels
Authors: te Beek Erik T. , Chen Xia , Jacobs Gabriël E. , Nahon Kimberly J. , de Kam Marieke L. , Lappalainen Jaakko , Cross Alan J. , van Gerven Joop M. A. , Hay Justin L. 
Published: June 2014

AbstractCompounds with selectivity for GABAA receptor subtypes may differ significantly from nonselective benzodiazepines in their dopaminergic effects in vivo. To explore the exact role of the GABAA receptor subtypes in the regulation of prolactin secretion and the differential effects of selective and nonselective GABA receptor modulators, the effects of the nonselective benzodiazepine lorazepam, as well as two novel α2/α3 subunit‐selective GABAA receptor modulators AZD7325 and AZD6280, on prolactin levels were measured in healthy male volunteers. Following administration of lorazepam at 2 mg doses and AZD6280 at 10 mg and 40 mg doses, prolactin levels increased significantly compared with placebo (difference 42.0%, 19.8%, and 32.8%, respectively), suggesting that the α2 and/or α3 receptor subtypes are involved in GABAergic modulation of prolactin secretion, although possible roles of the α1 and α5 receptor subtypes are not excluded. The increases in prolactin levels after administration of AZD7325 at 2 mg and 10 mg doses (difference 7.6% and 10.5%, respectively) did not reach statistical significance, suggesting that doses of AZD7325 or intrinsic efficacy at the α2 and α3 receptor subtypes may have been too low.
Effect of CYP2C19 polymorphism on the pharmacokinetics of rosuvastatin in healthy Taiwanese subjects
Authors: Finkelman Richard D. , Wang Tzung‐Dau , Wang Yi , Azumaya Connie T. , Birmingham Bruce K. , Wissmar Jenny , Mosqueda‐Garcia Rogelio 
Published: June 2014

AbstractCYP2C19 contributes to N‐desmethyl rosuvastatin formation in “in vitro” models. Approximately 80% of Taiwanese are CYP2C19 extensive metabolizers (EMs, CYP2C19*1/*1, *1/*2, or *1/*3). We studied the potential effect of CYP2C19 genotypes on rosuvastatin pharmacokinetics in healthy Taiwanese subjects following single and multiple daily oral doses of rosuvastatin calcium (20 mg). Geometric mean ratios for poor metabolizers (PMs): EMs for rosuvastatin were 0.974 and 0.872 for area under the curve and maximum plasma concentration on day 1 (1.01 and 0.965 on day 17) and for N‐desmethyl rosuvastatin, 1.21 and 1.07 on day 1 (1.14 and 1.09 on day 17), respectively. Changes of lipid profiles from baseline to day 18 for PMs and EMs were −52.4% and −53.3% (low‐density lipoprotein cholesterol), and −34.2% and −30.0% (total cholesterol), respectively. Rosuvastatin was generally well‐tolerated by both PMs and EMs. These results suggest that CYP2C19 polymorphism does not affect rosuvastatin pharmacokinetics in healthy Taiwanese in a clinically meaningful way.
Band‐Gap Manipulations of Monolayer Graphene by Phenyl Radical Adsorptions: A Density Functional Theory Study
Authors: Huang Lin , Sk Mahasin Alam , Chen Peng , Lim Kok Hwa 
Published: June 2014

AbstractPhenyl radical (Ph.) adsorption on monolayer graphene sheets is used to investigate the band‐gap manipulation of graphene through density functional theory. Adsorption of a single Ph. on graphene breaks the aromatic π‐bond and generates an unpaired electron, which is delocalized to the ortho or para position. Adsorption of a second radical at the ortho or para position saturates the radical by electron pairing and results in semiconducting graphene. Adsorption of a second radical at the ortho position (ortho–ortho pairing) is found to be more favorable than adsorption at the para position (ortho–para pairing), and the ortho–ortho pairing has stronger effects on band‐gap opening compared with ortho–para pairing. Adsorption of even numbers of Ph. on graphene by ortho–ortho and ortho–para pairings, in general, increases the band gap. Our study shows promise of band‐gap manipulation in monolayer graphene by Ph. adsorption, leading to potential wider applications of graphene.
Photocatalytic Hydrogen Evolution by Oleic Acid‐Capped CdS, CdSe, and CdS0.75Se0.25 Alloy Nanocrystals
Authors: Aslan Emre , Birinci Okan , Aljabour Abdalaziz , Özel Faruk , Akın Ilker , Hatay Patir Imren , Kus Mahmut , Ersoz Mustafa 
Published: June 2014

AbstractPhotocatalytic generation of hydrogen by using oleic acid‐capped CdS, CdSe, and CdS0.75Se0.25 alloy nanocrystals (quantum dots) has been investigated under visible‐light irradiation by employing Na2S and Na2SO3 as hole scavengers. Highly photostable CdS0.75Se0.25 alloy nanocrystals gave the highest hydrogen evolution rate (1466 μmol h−1 g−1), which was about three times higher than that of CdS and seven times higher than that of CdSe.
Tunable and Selective Conversion of 5‐HMF to 2,5‐Furandimethanol and 2,5‐Dimethylfuran over Copper‐Doped Porous Metal Oxides
Authors: Kumalaputri Angela J. , Bottari Giovanni , Erne Petra M. , Heeres Hero J. , Barta Katalin 
Published: June 2014

AbstractTunable and selective hydrogenation of the platform chemical 5‐hydroxymethylfurfural into valuable C6 building blocks and liquid fuel additives is achieved with copper‐doped porous metal oxides in ethanol. A new catalyst composition with improved hydrogenation/hydrogenolysis activity is obtained by introducing small amounts of ruthenium dopant into the previously reported Cu0.59Mg2.34Al1.00 structure. At a mild reaction temperature (100 °C), 2,5‐furandimethanol is obtained with excellent selectivity up to >99 %. Higher reaction temperatures (220 °C) favor selective deoxygenation to 2,5‐dimethylfuran and minor product 2,5‐dimethyltetrahydrofuran with a combined yield as high as 81 %. Notably, these high product yields are maintained at a substrate concentration up to 10 wt % and a low catalyst loading. The influence of different alcohol solvents on product selectivity is explored. Furthermore, reaction intermediates formed at different reaction temperatures are identified. The composition of these product mixtures provides mechanistic insight into the nature of the reduction pathways that influence product selectivity. The catalysts are characterized by elemental analysis, TEM, and BET techniques before and after the reaction. Catalyst recycling experiments are conducted in batch and in a continuous‐flow setup.
Lithium‐Ion Transport through a Tailored Disordered Phase on the LiNi0.5Mn1.5O4 Surface for High‐Power Cathode Materials
Authors: Jo Mi Ru , Kim Yong‐Il , Kim Yunok , Chae Ji Su , Roh Kwang Chul , Yoon Won‐Sub , Kang Yong‐Mook 
Published: June 2014

AbstractThe phase control of spinel LiNi0.5Mn1.5O4 was achieved through surface treatment that led to an enhancement of its electrochemical properties. Li+ diffusion inside spinel LiNi0.5Mn1.5O4 could be promoted by modifying the surface structure of LiNi0.5Mn1.5O4 through phosphidation into a disordered phase (Fd3m) that allows facile Li+ transport. Phosphidated LiNi0.5Mn1.5O4 showed a significantly enhanced electrochemical performance, even at high rates exceeding 10 C, demonstrating that the improved kinetics (related to the amount of Mn3+) can render LiNi0.5Mn1.5O4 competitive as a high‐power cathode material for electric vehicles and hybrid electric vehicles.
Decoration of Carbon Nanostructures with Metal Sulfides by Sonolysis of Single‐Molecule Precursors
Authors: Estrada Ana C. , Mendoza Ernest , Trindade Tito 
Published: June 2014

AbstractCarbon nanostructures have emerged in recent decades as uniquely convenient materials for a number of technologies. Some of their envisaged applications require hybrid nanostructures that result from the coupling of semiconducting phases to the carbon materials. Here, we describe a new sonochemical method to decorate carbon‐based materials (multiwalled carbon nanotubes, graphene oxide, and graphite flakes) with metal sulfide nanophases. In this research, we have used a CdII alkyldithiocarbamate complex as a single source to produce CdS nanophases that nucleate and grow over the carbon substrates. However, other metal sulfides can be produced by a similar methodology, which paves the way to a scalable method for the preparation of hybrid metal sulfide/carbon nanomaterials.
Stable N‐Phosphanyl Acyclic Diaminocarbenes
Authors: Marchenko Anatoliy , Koidan Georgyi , Hurieva Anastasiya , Kurpiieva Olena , Vlasenko Yurii , Rozhenko Alexander B. , Kostyuk Aleksandr 
Published: June 2014

AbstractThe deprotonation of N‐di‐tert‐butylphosphanyl‐N‐aryl‐N′‐diisopropylformamidinium salts led to a new type of stable acyclic N‐phosphanyl‐diaminocarbene (PADC). Carbenes 8a–8d were separated as single compounds. The molecular structure of 8c was determined by X‐ray diffraction analysis. The PADC 8 possess an optimal substitution pattern at the nitrogen atoms, and the N–Ccarbene–N bond angle is 120.7°. Structural changes near the carbenic carbon atom, such as substitution of phenyl with mesityl, phosphanyl with selenophosphoryl, or the diisopropylamino group with 2,2,6,6‐tetramethylpiperidino, rendered them unstable. The PADCs underwent N,C‐phosphorus shifts to afford new C‐phosphanylformamidines.
Preparation and physical properties of calcium pectinate films modified with sunflower wax
Authors: Baümler Erica R. , Carelli Amalia A. , Martini Silvana 
Published: June 2014

In this study, the preparation of films made from calcium pectinate (CP) and sunflower waxes (SFW) by casting is described. The optical properties, water resistance, thermal behavior, and rheological properties of SFW/CP films were examined. At higher SFW content irregular surfaces were obtained. Films made from a 2% aqueous pectin solution (PA) showed the best inclusion of the lipid material. Compared to SFW‐free films, SFW/CP films were less transparent, being the SFW concentration the responsible for the loss of transparency. The swelling index was affected by SFW inclusion and PA concentration. In general, water adsorption was not affected by SFW concentration, but it was affected by the environmental conditions. The inclusion of SFW did not improve the moisture barrier efficiency of the films. The thermal behavior of SFW/CP films revealed a melting peak in the range of 70–80°C attributed to the melting of SFW. The rheological analysis showed G′ values between 2.98 × 105 and 71.9 × 105 Pa for films stored at lower water activities, and they ranged from 3.07 × 105 to 38.4 × 105 Pa at higher environmental humidity. In both cases, G′ values were affected by SFW inclusion. A linear viscoelastic region (LVR) was observed for all the samples.Practical applications: A flexible and adequate film for handling and wrapping was obtained in this study. The addition of SFW to the CP films network was possible, and the films were easily prepared. This could be a potential application for waxes obtained from sunflower oil refining processes.Preparation of films made from calcium pectinate (CP) and sunflower waxes (SFW) by casting is described. The optical properties, water resistance, thermal behavior and rheological properties of SFW/CP films were also examined.
Convergent Synthesis and Conformational Analysis of the Hexasaccharide Repeating Unit of the O‐Antigen of Shigella flexneri Serotype 1d
Authors: Dhara Debashis , Kar Rajiv Kumar , Bhunia Anirban , Misra Anup Kumar 
Published: June 2014

AbstractA hexasaccharide repeating unit of the O‐antigen of the cell wall of Shigella flexneri type 1d has been synthesized using a stereoselective [3+3] block glycosylation approach. Recently developed glycosylation conditions were used in the synthesis. A thioglycoside was used as an orthogonal glycosyl donor during the synthesis. The synthesized hexasaccharide was subjected to detailed NMR spectroscopic and molecular modeling studies to determine its conformational behavior in water. The NOE‐based two‐dimensional NOSEY experiment and all‐atom explicit molecular dynamics (MD) simulation studies suggest that the oligosaccharide is not very flexible, that it remains rigid with respect to the glycosidic linkages between the sugar moieties.
Development of an adverse outcome pathway for acetylcholinesterase inhibition leading to acute mortality
Authors: Russom Christine L. , LaLone Carlie A. , Villeneuve Daniel L. , Ankley Gerald T. 
Published: June 2014

Abstract

Adverse outcome pathways (AOPs) are designed to describe linkages of key events within a biological pathway that result in an adverse outcome associated with chemical perturbation of a well-defined molecular initiating event. Risk assessors have traditionally relied on data from apical endpoints (e.g., mortality, growth, reproduction) to derive benchmark values for use in determining the potential adverse impacts of chemicals. One goal in building reliable and well-characterized AOPs is to identify relevant in vitro assays and/or in vivo biomarkers that could be used in screening the potential hazard of substances, thereby reducing costs and increasing the number of chemicals that can be evaluated in a timely fashion. The purpose of this review article is to build an AOP for substances with a molecular initiating event of acetylcholinesterase inhibition leading to acute mortality following guidance developed by the Organisation for Economic Cooperation and Development. In contrast to most other AOPs developed to date, in which coverage is for a relatively limited taxonomic group or life stage, this AOP is applicable to a wide range of species at multiple life stages. Furthermore, while development of most AOPs has relied on data for a few model chemicals, the AOP described in the present review captures information from a large number of studies with a diversity of organophosphate and carbamate insecticides. Environ Toxicol Chem 2014;33:2157–2169. Published 2014 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study
Authors: Mukaetova‐Ladinska Elizabeta B. , Abdel‐All Zeinab , Andrade Joana , Alves da Silva Joaquim , O'Brien John T. , Kalaria Raj N. 
Published: June 2014

BackgroundClusterin protein in plasma has been found to differentiate between people with and without cognitive changes. However, these findings are not conclusive, despite the clusterin gene variations repeatedly being linked to increased risk for dementia, in particular Alzheimer's disease (AD).MethodWe analysed the level of clusterin in platelet and plasma in 25 subjects with a clinical diagnosis of AD and 26 subjects with no cognitive impairment.ResultsIn the current study, we report that the levels of both plasma and platelet clusterin are similar between AD and cognitively intact individuals. Clusterin plasma and platelet levels, as well as the plasma/platelet clusterin ratio, were not affected by age, gender, cognitive impairment and/or overt behavioural symptomatology, including presence of hallucinations and delusions, as well as depression. However, the plasma/platelet clusterin ratio was positively associated in with the Neuropsychiatric Inventory measures of agitation, apathy, irritability and motor aberrant behaviour in AD subjects.ConclusionPrevious inconsistencies in reported blood clusterin levels may be a result of underlying non‐cognitive symptoms in people with AD. Our findings need now to be replicated in larger group of dementia subjects. Copyright © 2014 John Wiley & Sons, Ltd.