bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embryonic wound healing: A primer for engineering novel therapies for tissue repair
Authors: Degen Katherine E. , Gourdie Robert G. 
Published: October 2012

AbstractScar is the default tissue repair used by the body in response to most injuries–a response that occurs in wounds ranging in seriousness from minor skin cuts to complete severance of the spinal cord. By contrast, before the third trimester of pregnancy embryonic mammals tend to heal without scarring due to a variety of mechanisms and factors that are uniquely in operation during development in utero. The goal of tissue engineering is to develop safe and clinically effective biological substitutes that restore, maintain, or improve tissue function in patients. This review provides a comparative overview of wound healing during development and maturation and seeks to provide a perspective on just how much the embryo may be able teach us in the engineering of new therapies for tissue repair. Birth Defects Research (Part C) 96:258–270, 2012. © 2012 Wiley Periodicals, Inc.
When a domain is not a domain, and why it is important to properly filter proteins in databases
Authors: Towse Clare‐Louise , Daggett Valerie 
Published: October 2012

AbstractMembership in a protein domain database does not a domain make; a feature we realized when generating a consensus view of protein fold space with our consensus domain dictionary (CDD). This dictionary was used to select representative structures for characterization of the protein dynameome: the Dynameomics initiative. Through this endeavor we rejected a surprising 40% of the 1,695 folds in the CDD as being non‐autonomous folding units. Although some of this was due to the challenges of grouping similar fold topologies, the dissonance between the cataloguing and structural qualification of protein domains remains surprising. Another potential factor is previously overlooked intrinsic disorder; predictions suggest that 40% of proteins have either local or global disorder. One thing is clear, filtering a structural database and ensuring a consistent definition for protein domains is crucial, and caution is prescribed when generalizations of globular domains are drawn from unfiltered protein domain datasets.
Overview: Information architecture
Authors: Haller Thom 
Published: October 2012

AbstractEDITOR'S SUMMARYThis issue's special section delves into issues in information architecture and usability (IA/UX), ranging from the theoretical and conceptual to the practical. Authors explore the fundamental nature of information and evolving designs to support its complexity and translating patterns in semantic space to the screen and interface. The value of metaphors is shown for demonstrating information architecture to clients, while visual images can help illustrate the process. Last, an interview with Eric Reiss reveals the noted IA practitioner's thoughts on explaining usability to clients and his new publication.
Information architecture in the age of complexity
Authors: Resmini Andrea 
Published: October 2012

AbstractEDITOR'S SUMMARYWhile the distinction between complex and complicated may seem negligible, the key is understanding that complexity applies to a system that cannot be simulated, modeled and predicted. Website architecture within the Internet environment may be just such a system with evolving underlying technologies and demands, and handling their complexity is the information architect's challenge. Complexity is added by the undercurrent of social, cultural and economic influences, infusing pervasive layers of extra meaning, often indirect and detached from the immediate content in a postmodern sense. Progress has moved to postdigital, where the focus is on the user, not the technology, generating pseudo‐modern cultural products dependent on user interaction. The result is a new need for place and meaning that supports the user's cross‐channel experience. Resulting websites, still complex, may elude modeling, but with new meanings and structures emerging from a new style of usage, they can still be designed.
The Architecture of information
Authors: Dade‐Robertson Martyn 
Published: October 2012

AbstractEDITOR'S SUMMARYThe relationship among architecture, information and information architecture can be thought of from the perspective of architectural prehistory. The first instance of architecture may not have been a structure but the more conceptual designation and naming of territory, an information activity. Early representations of digital space drew heavily on images of buildings and cities as a visual medium. As information space has evolved, the link to any physical reality has vanished, though we retain the metaphor of navigation to make real the experience of interacting with the abstract on multiple levels. Users relate with information in semantic space, screen space and interaction space, each of which must be addressed by the information architect. The rise of ubiquitous computing may disrupt much of that conceptualization, leaving only an abstracted link between information and user action, with that interaction itself shaping the architectural space.
A conversation with eric reiss, author of usable usability: Simple steps for making stuff better
Authors: Haller Thom 
Published: October 2012

AbstractEDITOR'S SUMMARYIn an interview with the author, Eric Reiss discusses his contributions to information architecture, including his recent book, which explores usability from two angles. He breaks down the topic into “ease of use,” focusing on physical interaction, and “elegance and clarity,” addressing psychological aspects, each with five simple subtopics. The analysis lends itself to client presentations and to teaching students. Reiss prompts all to look at how well any product functions and at any website to consider its success on aspects including function, ergonomics, convenience, logic and predictability. Contemplating the foundations of his work, he traces his interest in usability back to redesigning a rocking horse as a three‐year‐old.
Palladium(II) Complexes with Small N‐Heterocyclic Carbene Ligands as Highly Active Catalysts for the Suzuki–Miyaura Cross‐Coupling Reaction
Authors: Szulmanowicz Michał S. , Gniewek Andrzej , Gil Wojciech , Trzeciak Anna M. 
Published: October 2012

AbstractFour new palladium(II) complexes of the type [Pd(NHC)2X2] with N‐heterocyclic carbene (NHC) ligands of relatively small steric hindrance were prepared and characterized by using spectroscopic and X‐ray methods. For [Pd(bmim‐y)2Br2] (bmim‐y=1‐butyl‐3‐methylimidazol‐2‐ylidene), crystals of both cis and trans isomers were obtained. All the studied complexes demonstrated very high activity in Suzuki–Miyaura cross‐coupling in ethylene glycol, which yielded turnover numbers of up to 760 000. High activity was also observed if NaBPh4 was used instead of PhB(OH)2, and the best results (turnover number=580 000) were obtained with [Pd(emim‐y)2Cl2] (emim‐y=1‐ethyl‐3‐methylimidazol‐2‐ylidene). In the reaction mixture, different forms containing [Pdx(NHC)y]+ fragments (x=1–4, y=2–5) were identified by using ESI‐MS. In the presence of Suzuki–Miyaura reaction substrates, catalytic palladium intermediates with aryl groups—[Pd(NHC)2Ph]+ and [Pd3(NHC)4Ph]+—were detected. Additional mechanistic investigations, such as TEM observations and mercury poisoning experiments, substantiated the formation of nanoparticles as a catalyst resting state. These heterogeneous particles serve as a reservoir for soluble palladium species—atoms or clusters that function as homogeneous catalysts for the Suzuki–Miyaura reaction.
Selecting Ceramic Grinding Media: Part 1 – Theory
Authors: Kotzé H. 
Published: October 2012

AbstractIn the mining industry where large volumes of grinding media per mill are required, media wear versus cost is a key optimization consideration. Quantification of in‐plant media wear is, however, often problematic. It can be done indirectly via small‐scale laboratory mill tests or potentially via measurement of the physical and mechanical properties of the media: size, density, sphericity, hardness, toughness, etc. While some of these parameters are easily quantifiable, hardness and toughness as indicators of media wear are not as straightforward. The importance of hardness and toughness of grinding media in the stirred‐mill environment are explained as well as the considerations that should be borne in mind when using these measurements as quality parameters. These considerations are given against the background of the various manufacturing methods of ceramic grinding media and the influence thereof on media quality.
Determination of Critical Factors in Implementing River Clean‐Up Projects: A Malaysian Case Study
Authors: Ismail Zubaidah , Salim Khatijah 
Published: October 2012

AbstractFast economic growth of a country contributes to the increase of activities that can also bring negative impacts on the rivers. Contamination of rivers, sedimentation, coastal erosion, decrease of aquatic life, and also flooding are some of these universal impacts. There are several rivers around the world, which are categorized as very polluted and require cleaning‐up operations. Several factors have been identified to be influencing factors in the success or otherwise of the implementation and operation of these projects. This study examined the factors related to the steps taken to clean‐up and rehabilitate these rivers and deduce by utilizing factor analysis the most critical success factors from the results obtained. A responsible river community is by far the most effective way to keep a river basin clean. Very often, however, cleaning‐up operations are necessary to revive and maintain the quality of the river so that it can be save to use as an important source of water for human consumption. It was found that community awareness was the most critical cluster of factors determining the success of the clean‐up work.
The role of eating and emotion in binge eating disorder and loss of control eating
Authors: Pollert Garrett A. , Engel Scott G. , Schreiber‐Gregory Deanna N. , Crosby Ross D. , Cao Li , Wonderlich Stephen A. , Tanofsky‐Kraff Marian , Mitchell James E. 
Published: October 2012

AbstractObjective:Binge eating, defined as the consumption of large amounts of food during which a sense of loss of control (LOC) is experienced, is associated with negative affect. However, there are no data on the experience of LOC after accounting for the effects of negative affect and caloric intake.Method:Nine adult patients with binge eating disorder (BED) and 13 obese nonbinge eating disorder (NBED) participants carried a palmtop computer for 7 days, rating momentary mood and sense of LOC multiple times each day. Electronic food logs were collected once daily.Results:After removing the effects of caloric intake and negative affect, a significant group difference was observed for ratings of LOC between BED and NBED participants.Discussion:These findings suggest the experience of LOC in adults with BED is a salient feature of binge episodes, beyond that explained by caloric intake and momentary affect. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
Modeling toxicity of binary metal mixtures (Cu2+–Ag+, Cu2+–Zn2+) to lettuce, Lactuca sativa, with the biotic ligand model
Authors: Yen Le T.T. , Vijver Martina G. , Jan Hendriks A. , Peijnenburg Willie J.G.M. 
Published: October 2012

Abstract
The biotic ligand model (BLM) was applied to predict metal toxicity to lettuce, Lactuca sativa. Cu2+ had the lowest median effective activity (EA50M), compared with Ag+ and Zn2+ (EA50Cu = 2.60 × 10−8 M, EA50Ag = 1.34 × 10−7 M, EA50Zn = 1.06 × 10−4 M). At the 50% response level, the fraction of the total number of biotic ligands occupied by ions (f50M) was lowest for Ag+ among the metals (f50Ag = 0.22, f50Cu = 0.36, f50Zn = 0.42). Cu2+ had the highest affinity for biotic ligands compared with Ag+ and Zn2+, as shown by stability constants of the cation–biotic ligand binding, expressed as log KMBL (log KCuBL = 7.40, log KAgBL = 6.39, log KZnBL = 4.00). Furthermore, the BLM was combined with the toxic equivalency factor approach in predicting toxicity of mixtures of Cu2+–Zn2+ and Cu2+–Ag+. The fraction of biotic ligands occupied by ions was used to determine the relative toxic potency of metals and the toxic equivalency quotient (TEQ) of mixtures. This approach allowed for including interactions in estimating mixture toxicity and showed good predictive power (r2 = 0.64–0.84). The TEQ at the 50% response level (TEQ50, Cu2+ equivalents) for Cu2+–Zn2+ mixtures was significantly lower than the value for Cu2+–Ag+ mixtures. Joint toxicity depended on both TEQ and specific composition of the mixture. The present study supports the use of the accumulation of metal ions at the biotic ligands as a predictor of toxicity of single metals and mixtures. Environ. Toxicol. Chem. 2013;32:137–143. © 2012 SETAC
Effects of repeated pulsed herbicide exposures on the growth of aquatic macrophytes
Authors: Boxall Alistair B.A. , Fogg Lindsay A. , Ashauer Roman , Bowles Teresa , Sinclair Chris J. , Colyer Alison , Brain Richard A. 
Published: October 2012

Abstract
Many contaminants are released into aquatic systems intermittently in a series of pulses. Pulse timing and magnitude can vary according to usage, compound-specific physicochemical properties, and use area characteristics. Standard laboratory ecotoxicity tests typically employ continuous exposure concentrations over defined durations and thus may not accurately and realistically reflect the effects of certain compounds on aquatic organisms, resulting in potential over- or underestimation. Consequently, the relative effects of pulsed (2 and 4 d) and continuous exposures of the duckweed Lemna minor to isoproturon, metsulfuron-methyl, and pentachlorophenol over a period of 42 d were explored in the present study. At the highest test concentrations, exposure of L. minor to pulses of metsulfuron-methyl resulted in effects on growth similar to those of an equivalent continuous exposure. For isoproturon, pulsed exposures had a lower impact than a corresponding continuous exposure, whereas the effect of pentachlorophenol delivered in pulses was greater. These differences may be explained by compound-specific uptake and degradation or dissipation rates in plants and the recovery potential that occurs following pulses for different pesticides. Given these results, use of a simple time-weighted average approach to estimate effects of intermittent exposures from short-term standard toxicity studies may not provide an accurate prediction that reflects realistic exposure scenarios. Development of mechanistic modeling approaches may facilitate better estimates of effects from intermittent exposures. Environ. Toxicol. Chem. 2013;32:193–200. © 2012 SETAC
Enantioselective toxicity and bioaccumulation of fipronil in fathead minnows (Pimephales promelas) following water and sediment exposures
Authors: Baird Suzanne , Garrison Arthur , Jones Jack , Avants Jimmy , Bringolf Robert , Black Marsha 
Published: October 2012

Abstract
Fipronil is a widely used, broad-spectrum pesticide that is applied as an equal mixture of two enantiomers. As regulations on older pesticides become more stringent, production and application of fipronil is expected to grow, leading to increased inputs into aquatic environments and complex exposures to biota. To better understand the potential exposures introduced by fipronil contamination, we conducted subchronic toxicity tests with larval fathead minnows (Pimephales promelas) and waterborne fipronil and its enantiomers and exposed juvenile fathead minnows to fipronil-spiked sediment. Enantioselective toxicity was observed in fish after the 7-d subchronic exposure, with increased toxicity of the racemate and (+) enantiomer observed compared with the (−) enantiomer. Curiously, toxicities of the racemate and (+) enantiomer were not significantly different, even though the racemate contains 50% of the (+) enantiomer and 50% of the less toxic (−) enantiomer. During the sediment exposure, racemic fipronil in sediment was transformed primarily to fipronil sulfide, while exposed fish rapidly accumulated fipronil and/or fipronil sulfide and transformed the majority to fipronil sulfone. Using the results of the sediment-exposure experiment, the authors explored a mechanism that may contribute to the interesting trends in enantioselective toxicity observed during the waterborne exposures. In tandem, the aquatic toxicity experiment and the spiked sediment exposure demonstrate the potentially complex behavior of fipronil in sediment and fish. Environ. Toxicol. Chem. 2013;32:222–227. © 2012 SETAC
Effects of bisphenol A on growth and nitrogen nutrition of roots of soybean seedlings
Authors: Sun Hai , Wang Lihong , Zhou Qing 
Published: October 2012

Abstract
Bisphenol A (BPA) is an environmental endocrine disruptor that seriously threatens ecological systems. Plants are the primary producers in ecological systems, but little information is available concerning the toxic effect of BPA on plants. In the present study, the effects of BPA on the growth and nitrogen nutrition of roots of soybean seedlings were investigated by using a root automatic scan apparatus and biochemical methods. It was found that when soybean seedlings were treated with 1.5 mg/L BPA, the growth of roots was improved, the content of nitrate in roots was increased, the content of ammonium in roots was decreased, and the activities of nitrate reductase and nitrite reductase in roots were not changed. The opposite effects were observed in roots treated with 17.2 mg/L and 50.0 mg/L BPA, except for an increase in the content of nitrate in roots treated with 17.2 mg/L BPA and a decrease in the activities of nitrate reductase and nitrite reductase in roots of soybeans seedlings. Statistical analysis indicated that the change in the nitrogen nutrition of roots of soybean seedlings treated with BPA was one reason why the growth of roots was changed. The authors suggest that the potential environmental and ecological risk of BPA to plants should receive more consideration. Environ. Toxicol. Chem. 2013;32:174–180. © 2012 SETAC
Bound‐based spectrum allocation for cooperative positioning
Authors: Raulefs R. , Zhang S. , Mensing C. 
Published: October 2012

ABSTRACTThis paper discusses the performance of distributed and centralised cooperative positioning system for multiple mobile terminals. A cooperative positioning system uses ranging between base stations and mobile terminals, and in addition exploits the links between the mobile terminals as well. However, the number of links in an all‐to‐all connected setup increases quadratically with the number of nodes. Our goal is to schedule the access for the available resources (used bandwidth) to track the nodes of a dynamic system. Therefore, it is essential to reason if the different links between the mobile terminals are useful. The reasoning assists in allocating resources properly. We investigate distributed algorithms that act based on the Cramér–Rao Lower Bound. We use as benchmark a centralised and much more complex algorithm that requires all link information and we ignore any latency aspects. The results show that our distributed algorithm using limited information performs well. Copyright © 2012 John Wiley & Sons, Ltd.
Cognitive Processing of Trauma and Attitudes Toward Disclosure in the First Six Months After Military Deployment
Authors: Currier Joseph M. , Lisman Ross , Irene Harris J. , Tait Rhondie , Erbes Christopher R. 
Published: October 2012

ObjectivesTo examine the role of cognitive processing and attitudes toward trauma disclosure among newly returned veterans of the Iraq and Afghanistan wars.MethodIn total, 110 veterans completed the Cognitive Processing of Trauma Scale, Disclosure of Trauma Questionnaire, and assessments of posttraumatic stress symptoms (PTSS), depression, and posttraumatic growth (PTG).ResultsBoth maladaptive and adaptive processing were the strongest predictors of PTSS and depression, ßs = .21 to .38. However, urge to discuss trauma was the main predictor of PTG, ß = .53. Correlational findings suggested that veterans’ willingness to discuss their traumas and reactivity to doing so were related with their processing of these experiences, rs = .23 to .40.ConclusionThis study provides further support for the critical intersection between cognitive processing and disclosure, while also suggesting the need for more research on the intra‐ and inter‐personal dimensions of these constructs in negative and constructive outcomes after trauma.
Expression of the male reproduction‐related gene in spermatic ducts of the blue swimming crab, Portunus pelagicus, and transfer of modified protein to the sperm acrosome
Authors: Sroyraya Morakot , Hanna Peter J. , Changklungmoa Narin , Senarai Thanyaporn , Siangcham Tanapan , Tinikul Yotsawan , Sobhon Prasert 
Published: October 2012

AbstractExpression of a sex‐specific gene in Macrobrachium rosenbergii (Mr‐Mrr), encoding a male reproduction‐related (Mrr) protein, has been identified in the spermatic ducts (SDs) and postulated to be involved in sperm maturation processes. M. rosenbergii is the only decapod that the expression and fate of the Mrr protein has been studied. To determine that this protein was conserved in decapods, we firstly used cloning techniques to identify the Mrr gene in two crabs, Portunus pelagicus (Pp‐Mrr) and Scylla serrata (Ss‐Mrr). We then investigated expression of Pp‐Mrr by in situ hybridization, and immunolocalization, as well as phosphorylation and glycosylation modifications, and the fate of the protein in the male reproductive tract. Pp‐Mrr was shown to have 632 nucleotides, and a deduced protein of 110 amino acids, with an unmodified molecular weight of 11.79 kDa and a mature protein with molecular weight of 9.16 kDa. In situ hybridization showed that Pp‐Mrr is expressed in the epithelium of the proximal, middle, distal SDs, and ejaculatory ducts. In Western blotting, proteins of 10.9 and 17.2 kDa from SDs were all positive using anti‐Mrr, antiphosphoserine/threonine, and antiphosphotyrosine. PAS staining showed they were also glycosylated. Immunolocalization studies showed Pp‐Mrr in the SD epithelium, lumen, and on the acrosomes of spermatozoa. Immunofluorescence staining indicated the acrosome of spermatozoa contained the Mrr protein, which is phosphorylated with serine/threonine and tyrosine, and also glycosylated. The Mrr is likely to be involved in acrosomal activation during fertilization of eggs. Microsc. Res. Tech., 2013. © 2012 Wiley Periodicals, Inc.
Managers' Interpersonal Skills and Their Role in Achieving Organizational Diversity and Inclusiveness
Authors: Mulqueen Casey , Kahn Amy , Kirkpatrick J. Stephen 
Published: October 2012

AbstractThis study is an analysis of workplace dynamics specific to diversity and inclusiveness (DI) as it relates to managerial effectiveness. The findings illustrate a direct correlation between the interpersonal skills related to versatility and leveraging diversity to sustain an inclusive organizational culture. The authors found that people can have a variety of individual behavioral styles or backgrounds, yet the key element to managerial effectiveness and organizational transformation is the level of versatility that an individual possesses. Much like the findings for emotional intelligence, this study offers an important perspective on individual effectiveness, attitude, and behavior. Managers can learn to be more versatile. This study provides an important mechanism to measure and achieve organizational results through versatility and effectiveness.