bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary intakes among South Asian adults differ by length of residence in the USA
Authors: Talegawkar Sameera A , Kandula Namratha R , Gadgil Meghana D , Desai Dipika , Kanaya Alka M 
Published: May 2015

AbstractObjectiveTo examine whether nutrient and food intakes among South Asian adult immigrants differ by length of residence in the USA.DesignCross-sectional analysis to examine differences in nutrient and food intakes by length of residence in the USA. Dietary data were collected using an interviewer-administered, culturally appropriate FFQ, while self-reported length of residence was assessed using a questionnaire and modelled as tertiles.SettingThe Mediators of Atherosclerosis in South Asians Living in America (MASALA) study.SubjectsEight hundred and seventy-four South Asians (mean age=55 (sd 9) years; 47 % women; range of length of residence in the USA=2–58 years), part of the baseline examination of the MASALA study.ResultsIntakes of fat, including saturated and trans fats, dietary cholesterol and n-6 fatty acids, were directly associated with length of residence, while intakes of energy, carbohydrate, glycaemic index and load, protein, dietary fibre, folate and K were inversely associated with length of residence (P trend <0·05). A longer length of residence in the USA was also associated with higher intakes of alcoholic beverages, mixed dishes including pizza and pasta, fats and oils, and lower intakes of beans and lentils, breads, grains and flour products, milk and dairy products, rice, starchy vegetables and sugar, candy and jam (P for differences across groups <0·05).ConclusionsLength of residence in the USA influences diet and nutrient intakes among South Asian adult immigrants and should be considered when investigating and planning dietary interventions to mitigate chronic disease risk.
Speed of eating and 3-year BMI change: a nationwide prospective study of mid-age women
Authors: Leong Sook Ling , Gray Andrew , Horwath Caroline C 
Published: May 2015

AbstractObjectiveTo conduct the first nationwide population survey to examine the associations between changes in speed of eating and weight gain over 3 years. The study also explored whether faster eating at baseline was related to healthy-weight women becoming overweight after 3 years.DesignLongitudinal. At baseline, participants were randomly selected from a nationally representative sampling frame to participate in a prospective study. Women completed self-administered baseline questionnaires on demographic and health measures. Self-reported speed of eating, smoking status, physical activity, menopause status, and height and weight were collected at baseline and again 3 years later.SettingNationwide study, New Zealand.SubjectsWomen (n 1601) aged 40–50 years were recruited at baseline from New Zealand electoral rolls.ResultsThere was no evidence of associations between 3-year BMI adjusting for baseline BMI and either baseline speed of eating (slower and faster; P=0·524) or change in speed of eating (consistently faster eating, consistently slower eating, slower eating at baseline but not at 3 years, faster eating at baseline but not at 3 years; P=0·845). Of the 488 women with healthy BMI (18·5 to <25·0 kg/m2) at baseline, seventy-seven (15·8 %) became overweight (BMI≥25·0 kg/m2) after 3 years. Compared with those who were slower eaters at baseline, faster eating at baseline did not increase the risk of becoming overweight 3 years later (P=0·958) nor did change in speed of eating (P=0·236).ConclusionsResults suggest that once women have reached mid-life, faster eating does not predict further weight gain.
No moment wasted: the primary-care visit for adults with diabetes and low socio-economic status
Authors: Bolen Shari D. , Sage Paulette , Perzynski Adam T. , Stange Kurt C. 
Published: May 2015

AimTo better understand the type and range of health issues initiated by patients and providers in ‘high-quality’ primary-care for adults with diabetes and low socio-economic status (SES).BackgroundAlthough quality of care guidelines are straightforward, diabetes visits in primary care are often more complex than adhering to guidelines, especially in adults with low SES who experience many financial and environmental barriers to good care.MethodsWe conducted a qualitative study using direct observation of primary-care diabetes visits at an exemplar safety net practice in 2009–2010.FindingsIn a mainly African American (93%) low-income population with fair cardiovascular control (mean A1c 7.5%, BP 134/81 mmHg, and low-density lipoprotein cholesterol 100 mg/dL), visits addressed a variety of bio-psychosocial health issues [median: 25 problems/visit (range 13–32)]. Physicians most frequently initiated discussions about chronic diseases, prevention, and health behavior. Patients most frequently initiated discussions about social environment and acute symptoms followed by prevention and health behavior.ConclusionsPrimary-care visits by diabetes patients with low SES address a surprising number and diversity of problems. Emerging new models of primary-care delivery and quality measurement should allow adequate time and resources to address the range of tasks necessary for integrating biomedical and psychosocial concerns to improve the health of socio-economically disadvantaged patients.
Views of practice managers and general practitioners on implementing NHS Health Checks
Authors: Krska Janet , du Plessis Ruth , Chellaswamy Hannah 
Published: May 2015

As part of an evaluation of a contract with general practices to deliver the national NHS Health Checks programme in Sefton, North West England, we surveyed general practitioners (GPs) and practice managers (PMs) in all 55 practices.The contract required practices to identify individuals from their practice registers with potentially high cardiovascular disease risk, and provide annual reviews. Responses were obtained from 43/178 GPs and 40/55 PMs representing 56 and 73% of practices, respectively. There was variation in many aspects of implementation. Time and software were viewed as barriers to implementation, the increased nurse workload impacted on other services and payments were insufficient to cover costs. The main enabler for successful implementation was IT support. Fewer than half the respondents viewed the programme as beneficial to their practice.Findings have been used to address many issues raised. Practices need more support from commissioners to help implement NHS Health Checks.
Simulating super earth atmospheres in the laboratory
Authors: Claudi R. , Erculiani M. S. , Galletta G. , Billi D. , Pace E. , Schierano D. , Giro E. , D'Alessandro M. 
Published: May 2015

AbstractSeveral space missions, such as JWST, TESS and the very recently proposed ARIEL, or ground-based experiments, as SPHERE and GPI, have been proposed to measure the atmospheric transmission, reflection and emission spectra of extrasolar planets. The planet atmosphere characteristics and possible biosignatures will be inferred by studying planetary spectra in order to identify the emission/absorption lines/bands from atmospheric molecules such as water (H2O), carbon monoxide (CO), methane (CH4), ammonia (NH3), etc. In particular, it is important to know in detail the optical characteristics of gases in the typical physical conditions of the planetary atmospheres and how these characteristics could be affected by radiation driven photochemical and biochemical reaction. The main aim of the project ‘Atmosphere in a Test Tube’ is to provide insights on exoplanet atmosphere modification due to biological intervention. This can be achieved simulating planetary atmosphere at different pressure and temperature conditions under the effects of radiation sources, used as proxies of different bands of the stellar emission. We are tackling the characterization of extrasolar planet atmospheres by mean of innovative laboratory experiments described in this paper. The experiments are intended to reproduce the conditions on warm earths and super earths hosted by low-mass M dwarfs primaries with the aim to understand if a cyanobacteria population hosted on a Earth-like planet orbiting an M0 star is able to maintain its photosynthetic activity and produce traceable signatures.
Remote sensing of life: polarimetric signatures of photosynthetic pigments as sensitive biomarkers
Authors: Berdyugina Svetlana V. , Kuhn Jeff R. , Harrington David M. , Šantl-Temkiv Tina , Messersmith E. John 
Published: May 2015

AbstractWe develop a polarimetry-based remote-sensing method for detecting and identifying life forms in distant worlds and distinguishing them from non-biological species. To achieve this we have designed and built a bio-polarimetric laboratory experiment BioPol for measuring optical polarized spectra of various biological and non-biological samples. Here we focus on biological pigments, which are common in plants and bacteria that employ them either for photosynthesis or for protection against reactive oxygen species. Photosynthesis, which provides organisms with the ability to use light as a source of energy, emerged early in the evolution of life on Earth. The ability to harvest such a significant energy resource could likely also develop on habited exoplanets. Thus, we investigate the detectability of biomolecules that can capture photons of particular wavelengths and contribute to storing their energy in chemical bonds. We have carried out laboratory spectropolarimetric measurements of a representative sample of plants containing various amounts of pigments such as chlorophyll, carotenoids and others. We have also measured a variety of non-biological samples (sands, rocks). Using our lab measurements, we have modelled intensity and polarized spectra of Earth-like planets having different surface coverage by photosynthetic organisms, deserted land and ocean, as well as clouds. Our results demonstrate that linearly polarized spectra provide very sensitive and rather unambiguous detection of photosynthetic pigments of various kinds. Our work paves the path towards analogous measurements of microorganisms and remote sensing of microbial ecology on the Earth and of extraterrestrial life on other planets and moons.
THE ENDURING CHALLENGE OF RACIAL INTEGRATION IN THE UNITED STATES
Authors: Stanley Sharon 
Published: May 2015

AbstractThis paper formulates a new model of racial integration for African Americans in the United States, based upon a careful consideration of the weaknesses in previous models. Instead of spatial mixing, this model of integration calls for transformed habits of interaction between citizens in public spaces, as well as a redistribution of power, understood as access to resources and opportunities. Integration along these lines would produce mutual transformation rather than compulsory assimilation. However, this model does not necessarily answer the concerns of integration critics who question the capacity of the United States to achieve true racial equality. Hence, the conclusion considers three significant obstacles to the achievement of integration, and acknowledges that unprecedented, radical transformations would be necessary to lay the groundwork for integration. In the end, both integration pessimism and a renewed commitment to integration are reasonable and defensible responses to our still-segregated present.
First record of Anachis aliceae (Mollusca: Gastropoda: Columbellidae) in the Algarve, south coast of Portugal
Authors: Afonso Carlos M.L. , Monsecour Kevin 
Published: May 2015

The marine gastropodAnachis aliceae(Pallary, 1900) is reported with certainty for the first time from the Algarve, south coast of Portugal from species-rich rocky priority biotope. Several live specimens of this species belonging to the Columbellidae family were collected and identified from by-catch samples, recovered from octopus traps set at depths between 50 and 70 m off Ponta da Piedade. Taxonomic validation of the newly recorded species is based on the comparison to other related species within the genus.
First record of the megamouth shark, Megachasma pelagios, (Chondrichthyes: Lamniformes: Megachasmidae) from Sri Lanka, northern Indian Ocean
Authors: Fernando Daniel , Perera Nishan , Ebert David A. 
Published: May 2015

The megamouth shark,Megachasma pelagios, is a rare and poorly studied shark. In this paper, the first record of the megamouth shark is reported for Sri Lanka. The shark, a juvenile estimated at 180 cm in total length, was caught in a gillnet in close proximity (&lt;92 km) to the Negombo fisheries harbour (7°12′11.67″N 79°49′44.35″E).
The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome
Authors: Zhou Yang , Zhu Jianguo , Schermann Géza , Ohle Corina , Bendrin Katja , Sugioka-Sugiyama Rie , Sugiyama Tomoyasu , Fischer Tamás 
Published: May 2015

AbstractCryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the exosome is not fully understood. Here we report that the MTREC complex, which has recently been shown to promote degradation of meiotic mRNAs and regulatory ncRNAs, is also the major nuclear exosome targeting complex for CUTs and unspliced pre-mRNAs in Schizosaccharomyces pombe. The MTREC complex specifically binds to CUTs, meiotic mRNAs and unspliced pre-mRNA transcripts and targets these RNAs for degradation by the nuclear exosome, while the TRAMP complex has only a minor role in this process. The MTREC complex physically interacts with the nuclear exosome and with various RNA-binding and RNA-processing complexes, coupling RNA processing to the RNA degradation machinery. Our study reveals the central role of the evolutionarily conserved MTREC complex in RNA quality control, and in the recognition and elimination of CUTs.
Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry
Authors: Engelen Erik , Brandsma Johannes H. , Moen Maaike J. , Signorile Luca , Dekkers Dick H. W. , Demmers Jeroen , Kockx Christel E. M. , Ozgür Zehila , van IJcken Wilfred F. J. , van den Berg Debbie L. C. , Poot Raymond A. 
Published: May 2015

AbstractThe locations of transcriptional enhancers and promoters were recently mapped in many mammalian cell types. Proteins that bind those regulatory regions can determine cell identity but have not been systematically identified. Here we purify native enhancers, promoters or heterochromatin from embryonic stem cells by chromatin immunoprecipitations (ChIP) for characteristic histone modifications and identify associated proteins using mass spectrometry (MS). 239 factors are identified and predicted to bind enhancers or promoters with different levels of activity, or heterochromatin. Published genome-wide data indicate a high accuracy of location prediction by ChIP-MS. A quarter of the identified factors are important for pluripotency and includes Oct4, Esrrb, Klf5, Mycn and Dppa2, factors that drive reprogramming to pluripotent stem cells. We determined the genome-wide binding sites of Dppa2 and find that Dppa2 operates outside the classical pluripotency network. Our ChIP-MS method provides a detailed read-out of the transcriptional landscape representative of the investigated cell type.
Predicting disease progression from short biomarker series using expert advice algorithm
Authors: Morino Kai , Hirata Yoshito , Tomioka Ryota , Kashima Hisashi , Yamanishi Kenji , Hayashi Norihiro , Egawa Shin , Aihara Kazuyuki 
Published: May 2015

AbstractWell-trained clinicians may be able to provide diagnosis and prognosis from very short biomarker series using information and experience gained from previous patients. Although mathematical methods can potentially help clinicians to predict the progression of diseases, there is no method so far that estimates the patient state from very short time-series of a biomarker for making diagnosis and/or prognosis by employing the information of previous patients. Here, we propose a mathematical framework for integrating other patients' datasets to infer and predict the state of the disease in the current patient based on their short history. We extend a machine-learning framework of “prediction with expert advice” to deal with unstable dynamics. We construct this mathematical framework by combining expert advice with a mathematical model of prostate cancer. Our model predicted well the individual biomarker series of patients with prostate cancer that are used as clinical samples.
NEMS With Broken T Symmetry: Graphene Based Unidirectional Acoustic Transmission Lines
Authors: Zanjani Mehdi B. , Davoyan Arthur R. , Engheta Nader , Lukes Jennifer R. 
Published: May 2015

AbstractIn this work we discuss the idea of one-way acoustic signal isolation in low dimensional nanoelectromechanical oscillators. We report a theoretical study showing that one-way conversion between in-phase and anti-phase vibrational modes of a double layer graphene nanoribbon is achieved by introducing spatio-temporal modulation of system properties. The required modulation length in order to reach full conversion between the two modes is subsequently calculated. Generalization of the method beyond graphene nanoribbons and realization of a NEMS signal isolator are also discussed.
Transcriptome sequencing of three Ranunculus species (Ranunculaceae) reveals candidate genes in adaptation from terrestrial to aquatic habitats
Authors: Chen Ling-Yun , Zhao Shu-Ying , Wang Qing-Feng , Moody Michael L. 
Published: May 2015

AbstractAdaptation to aquatic habitats is a formidable challenge for terrestrial angiosperms that has long intrigued scientists. As part of a suite of work to explore the molecular mechanism of adaptation to aquatic habitats, we here sequenced the transcriptome of the submerged aquatic plant Ranunculus bungei and two terrestrial relatives R. cantoniensis and R. brotherusii, followed by comparative evolutionary analyses to determine candidate genes for adaption to aquatic habitats. We obtained 126,037, 140,218 and 114,753 contigs for R. bungei, R. cantoniensis and R. brotherusii respectively. Bidirectional Best Hit method and OrthoMCL method identified 11,362 and 8,174 1:1:1 orthologous genes (one ortholog is represented in each of the three species) respectively. Non-synonymous/synonymous (dN/dS) analyses were performed with a maximum likelihood method and an approximate method for the three species-pairs. In total, 14 genes of R. bungei potentially involved in the adaptive transition from terrestrial to aquatic habitats were identified. Some of the homologs to these genes in model plants are involved in vacuole protein formation, regulating ‘water transport process’ and ‘microtubule cytoskeleton organization’. Our study opens the door to understand the molecular mechanism of plant adaptation from terrestrial to aquatic habitats.
Crustal movements due to Iceland’s shrinking ice caps mimic magma inflow signal at Katla volcano
Authors: Spaans Karsten , Hreinsdóttir Sigrún , Hooper Andrew , Ófeigsson Benedikt Gunnar 
Published: May 2015

AbstractMany volcanic systems around the world are located beneath, or in close proximity to, ice caps. Mass change of these ice caps causes surface movements, which are typically neglected when interpreting surface deformation measurements around these volcanoes. These movements can however be significant and may closely resemble movements due to magma accumulation. Here we show such an example, from Katla volcano, Iceland. Horizontal movements observed by GPS on the flank of Katla have led to the inference of significant inflow of magma into a chamber beneath the caldera, starting in 2000 and continuing over several years. We use satellite radar interferometry and GPS data to show that between 2001 and 2010, the horizontal movements seen on the flank can be explained by the response to the long term shrinking of ice caps and that erratic movements seen at stations within the caldera are also not likely to signify magma inflow. It is important that interpretations of geodetic measurements at volcanoes in glaciated areas consider the effect of ice mass change and previous studies should be carefully reevaluated.
Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells
Authors: Nygaard Marie Berg , Almstrup Kristian , Lindbæk Louise , Christensen Søren Tvorup , Svingen Terje 
Published: May 2015

AbstractPrimary cilia are sensory organelles that coordinate numerous cellular signalling pathways during development and adulthood. Defects in ciliary assembly or function lead to a series of developmental disorders and diseases commonly referred to as ciliopathies. Still, little is known about the formation and function of primary cilia in the mammalian testis. Here, we characterized primary cilia in adult human testis and report a constitutive expression of cilia in peritubular myoid cells and a dynamic expression of cilia in differentiating Leydig cells. Primary cilia are generally absent from cells of mature seminiferous epithelium, but present in Sertoli cell-only tubules in Klinefelter syndrome testis. Peritubular cells in atrophic testis produce overly long cilia. Furthermore cultures of growth-arrested immature mouse Leydig cells express primary cilia that are enriched in components of Hedgehog signalling, including Smoothened, Patched-1 and GLI2, which are involved in regulating Leydig cell differentiation. Stimulation of Hedgehog signalling increases the localization of Smoothened to the cilium, which is followed by transactivation of the Hedgehog target genes, Gli1 and Ptch1. Our findings provide new information on the spatiotemporal formation of primary cilia in the testis and show that primary cilia in immature Leydig cells mediate Hedgehog signalling.
Cyclin-dependent kinase 11p110 (CDK11p110) is crucial for human breast cancer cell proliferation and growth
Authors: Zhou Yubing , Han Chao , Li Duolu , Yu Zujiang , Li Fengmei , Li Feng , An Qi , Bai Huili , Zhang Xiaojian , Duan Zhenfeng , Kan Quancheng 
Published: May 2015

AbstractCyclin-dependent kinases (CDKs) play important roles in the development of many types of cancers by binding with their paired cyclins. However, the function of CDK11 larger protein isomer, CDK11p110, in the tumorigenesis of human breast cancer remains unclear. In the present study, we explored the effects and molecular mechanisms of CDK11p110 in the proliferation and growth of breast cancer cells by determining the expression of CDK11p110 in breast tumor tissues and examining the phenotypic changes of breast cancer cells after CDK11p110 knockdown. We found that CDK11p110 was highly expressed in breast tumor tissues and cell lines. Tissue microarray analysis showed that elevated CDK11p110 expression in breast cancer tissues significantly correlated with poor differentiation and was also associated with advanced TNM stage and poor clinical prognosis for breast cancer patients. In vitro knockdown of CDK11p110 by siRNA significantly inhibited cell growth and migration and dramatically induced apoptosis in breast cancer cells. Flow cytometry demonstrated that cells were markedly arrested in G1 phase of the cell cycle after CDK11p110 downregulation. These findings suggest that CDK11p110 is critical for the proliferation and growth of breast cancer cells, which highlights CDK11p110 may be a promising therapeutic target for the treatment of breast cancer.