bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac extracellular proteome profiling and membrane topology analysis using glycoproteomics
Authors: Tian Yuan , Koganti Tejaswi , Yao Zhihao , Cannon Presley , Shah Punit , Pietrovito Laura , Modesti Alessandra , Aiyetan Paul , DeLeon‐Pennell Kristine , Ma Yonggang , Halade Ganesh V. , Hicks Chindo , Zhang Hui , Lindsey Merry L. 
Published: June 2014

PurposeExtracellular proteins are easily accessible, which presents a subproteome of molecular targets that have high diagnostic and therapeutic potential. Efforts have been made to catalog the cardiac extracellular matridome and analyze the topology of identified proteins for the design of therapeutic targets. Although many bioinformatics tools have been developed to predict protein topology, topology has been experimentally validated for only a very small portion of membrane proteins. The aim of this study was to use a glycoproteomics and MS approach to identify glycoproteins in the extracellular matridome of the infarcted left ventricle (LV) and provide experimental evidence for topological determination.Experimental designGlycoproteomics analysis was performed on eight biological replicates of LV samples from wild‐type mice at 7 days following myocardial infarction using SPE of glycopeptides, followed by mass spectrometric identification of N‐linked glycosylation sites for topology assessment.ResultsWe identified hundreds of glycoproteins, and the identified N‐glycosylation sites provide novel information on the correct topology for membrane proteins present in the infarct setting.Conclusions and clinical relevanceOur data provide the foundation for future studies of the LV infarct extracellular matridome, which may facilitate the discovery of drug targets and biomarkers.
Synoptic versus orographic control on stationary convective banding
Authors: Barrett Andrew I. , Gray Suzanne L. , Kirshbaum Daniel J. , Roberts Nigel M. , Schultz David M. , Fairman Jonathan G. 
Published: June 2014

Quasi‐stationary convective bands can cause large localised rainfall accumulations and are often anchored by topographic features. Here, the predictability of and mechanisms causing one such band are determined using ensembles of the Met Office Unified Model at convection‐permitting resolution (1.5 km grid length). The band was stationary over the UK for 3 h and produced rainfall accumulations of up to 34 mm. The amount and location of the predicted rainfall was highly variable despite only small differences between the large‐scale conditions of the ensemble members. Only three of 21 members of the control ensemble produced a stationary rain band; these three had the weakest upstream winds and hence lowest Froude number. Band formation was due to the superposition of two processes: lee‐side convergence resulting from flow around an upstream obstacle and thermally forced convergence resulting from elevated heating over the upstream terrain. Both mechanisms were enhanced when the Froude number was lower. By increasing the terrain height (thus reducing the Froude number), the band became more predictable.An ensemble approach is required to successfully predict the possible occurrence of such quasi‐stationary convective events because the rainfall variability is largely modulated by small variations of the large‐scale flow. However, high‐resolution models are required to accurately resolve the small‐scale interactions of the flow with the topography upon which the band formation depends. Thus, although topography provides some predictability, the quasi‐stationary convective bands anchored by it are likely to remain a forecasting challenge for many years to come.
Robust Monitoring of an Industrial IT System in the Presence of Structural Change
Authors: Padonou Esperan , Roustant Olivier , Lutz Michel 
Published: June 2014

This paper presents original research initiated by the monitoring needs of a semiconductor production plant. The industrial operations rely on an Information Technology (IT) system, and several time series data are controlled statistically. Unfortunately, these variables often contain outliers, as well as structural changes because of external decisions in the IT activity. As a consequence, it has been observed that the monitoring results obtained with standard techniques could be severely biased.This paper attempts to overcome such difficulties. A new monitoring method is proposed, based on robust Holt–Winters smoothing algorithm, and coupled with a relearning procedure for structural break detection. Such a method is flexible enough for a large‐scale industrial application. We evaluate performance through simulation and show its usefulness in real industrial applications for univariate and multivariate time series. The scope of application deals with IT activity monitoring, but the introduced statistical methods are generic enough for being used in other industrial fields. Copyright © 2014 John Wiley & Sons, Ltd.
A dynamic stochastic model for automatic grammar‐based test generation
Authors: Guo Hai‐Feng , Qiu Zongyan 
Published: June 2014

SummaryGrammar‐based test generation provides a systematic approach to producing test cases from a given context‐free grammar. Unfortunately, naive grammar‐based test generation is problematic because of the fact that exhaustive random test case production is often explosive, and grammar‐based test generation with explicit annotation controls often causes unbalanced testing coverage. In this paper, we present an automatic grammar‐based test generation approach, which takes a symbolic grammar as input, requires zero control input from users, and produces well‐distributed test cases. Our approach utilizes a novel dynamic stochastic model where each variable is associated with a tuple of probability distributions, which are dynamically adjusted along the derivation. We further present a coverage tree illustrating the distribution of generated test cases and their detailed derivations. More importantly, the coverage tree supports various implicit derivation control mechanisms. We implemented this approach in a Java‐based system, named Gena. Each test case generated by Gena automatically comes with a set of structural features, which can play an important and effective role on automated failure causes localization. Experimental results demonstrate the effectiveness of our approach, the well‐balanced distribution of generated test cases over grammatical structures, and a case study on grammar‐based failure causes localization. Copyright © 2014 John Wiley & Sons, Ltd.
Outage probability in Poisson‐cluster‐based LTE two‐tier femtocell networks
Authors: Jakó Zoltán , Jeney Gábor 
Published: June 2014

AbstractThis paper analyzes two‐tier orthogonal frequency‐division multiplexing (OFDM)‐based cellular structure, when the traditional macrocell structure is extended with femtocells. The benefit of using femtocells is the capacity and coverage extension capability. To fulfill strict quality of service requirements in next‐generation mobile networks such as Long Term Evolution (LTE) or LTE‐Advanced, capacity and coverage enhancing becomes rather important. On the other hand, adding small cells such as femtocells next to macrocell modifies the interference pattern of the current region. Therefore, the number of small cells in a given area should be limited. In this paper, we provide an analytic framework to calculate the outage probability for a macrocell user in OFDM‐based femtocell networks when the deployed femto base stations are composing an independent Poisson cluster process such as Thomas cluster process. Cluster‐based femtocell modeling offers accurate network planning for mobile operators. In this cluster‐based realization, we give an interference characterization and consider the outage probability for a randomly deployed user when communication channel is infected with Rayleigh fading. Copyright © 2014 John Wiley & Sons, Ltd.
Estimation of lightning current amplitudes incident to wind turbines in exposed locations
Authors: Sarajcev P. , Goic R. 
Published: June 2014

AbstractThis paper proposes a novel and comprehensive methodology for estimation of lightning current amplitudes, which are incident to wind turbines (WT) at lightning‐exposed locations, i.e., hilltops. The proposed methodology takes into the account the following aspects related to WT lightning incidence: (i) site topology and keraunic level, (ii)statistical nature of lightning currents, (iii) WT effective height, (iv) dependence of lightning current amplitudes on the WT effective height, (v) influence of an upward‐initiated connecting streamers interaction with a downward‐propagating step leader on the WT lightning attractiveness, and (vi) both downward and upward lightning strikes and their relative contribution in relation to the WT effective height. This methodology could be perceived as beneficial in providing relevant lightning‐current amplitudes—particularly at lightning‐endangered locations and wind farm sites characterized by high soil resistivity—for wind turbine and wind farm overvoltage protection and backsurge studies, as well as the WT grounding systems transient analysis. Copyright © 2014 John Wiley & Sons, Ltd.
Dynamic evaluation of two configurations for a hybrid DFIG‐based wind turbine integrating battery energy storage system
Authors: Sarrias‐Mena Raúl , Fernández‐Ramírez Luis M. , García‐Vázquez Carlos Andrés , Jurado Francisco 
Published: June 2014

AbstractHybrid systems comprising battery energy storage systems (BESSs) and wind power generation entail considerable advances on the grid integration of renewable energy. Doubly fed induction generators (DFIGs) stand out among different wind turbine (WT) technologies. On the other hand, electrochemical batteries have proved to be valid for these purposes. In this paper, a comparative analysis is carried out between two alternative configurations for hybrid WT‐BESS systems, where the BESS is connected either outside or inside the DFIG. The modeling of these two configurations and the control systems applied for achieving the coordinate operation of the energy sources (DFIG and batteries) are illustrated. The hybrid systems under study are evaluated by simulation under normal operation (wind speed fluctuations and grid demand changes) and grid faults. Simulation results show that both configurations improve the grid integration capability of the WT, although the configuration with external BESS presents better results since it can provide additional active/reactive power injection. Copyright © 2014 John Wiley & Sons, Ltd.
Responses of forest snail assemblages to soil acidity buffer system and liming
Authors: Kappes Heike , Topp Werner 
Published: June 2014

AbstractPhysiological constraints from harsh environmental conditions, such as from calcium limitation on acidic soils, is expected not only to affect species richness, but also species abundance distributions. Also, the effects of amendments by calcium addition (soil liming) on these assemblage characteristics are poorly understood. Because of their sensitivity towards calcium availability, we use snails as model organisms and integrate field surveys and literature data. Temperate forest snail data supported a rule‐of‐thumb calibration with pH measurements in water being one unit higher than in KCl buffer. The resulting large data set suggests stepwise changes in snail richness that occur at transitions in soil buffer systems, especially at pH 3.2. Species abundance distributions follow the logseries model in most soil buffer systems, except for the iron buffer range (pH ≤3.2) where they swap to the geometric model. Our findings thus suggest several smaller soil pH thresholds for snail assemblages associated with shifts between soil buffer systems, and a tipping point at the threshold to pH ≤3.2. Liming with ground carbonate rocks is a technique to temporarily increase soil pH and calcium availability in forest soils, but its effects on snail assemblages produced inconsistent results that did not meet expectations from the ameliorated soil pH and might warrant a re‐evaluation of liming applications.
Effect of Preservation of Corticoperiosteal Attachment on Bone Healing at Osteotomy Sites after Ulna-shortening Osteotomy
Authors: Hamada Yoshitaka , Sairyo Koichi , Hibino Naohito , Kobayashi Anna , Sato Ryosuke 
Published: June 2014

Background Although precise ulna-shortening osteotomy is popular, the procedure sometimes results in delayed union or nonunion. The periosteum including the inner cambium layer plays an important role in fracture healing. We tested the hypothesis that preservation of the corticoperiosteal attachment may accelerate healing at osteotomy sites after ulna-shortening osteotomy. Methods We performed a chart review of 32 patients who underwent ulna-shortening osteotomy for ulnar impaction syndrome or triangular fibrocartilage complex tears in a retrospective single-surgeon series. Of the 32 cases, the periosteum was preserved in 21 osteotomies performed from April 2009 onwards (periosteum-preserved group) and not preserved in 11 osteotomies performed before April 2009 (control group). Following sugar tong immobilization, patients in both groups used a short wrist supporter during the first two postoperative weeks (POW) and up to at least four POW. Union of the osteotomy site was assessed at 2-week intervals using radiographs taken at three different projections until 12 POW and at 4-week intervals thereafter until 24 POW. Ulna shortening was performed using a transverse osteotomy cut with the aid of a commercially available compression device. Results All osteotomies achieved complete union except in one case in the control group. The mean interval to complete cortical union was 7.7 weeks in the periosteum-preserved group and 9.5 weeks in the control group. The corresponding mean times for endosteal union were 15.6 and 21.8 weeks. The periosteum-preserved group had reduced times for both types of union but only the endosteal union time was significantly different from the control group. Conclusions Preservation of the corticoperiosteal attachment significantly shortened the endosteal union time. Our results indicate that preservation of the periosteum may accelerate bone healing after ulna-shortening osteotomy. Type of study/level of evidence Therapeutic IV
Reversible Solubilization of Typical Polycyclic Aromatic Hydrocarbons (PAH) by a Gas Switchable Surfactant
Authors: Tian Senlin , Long Jian , He Shanshan 
Published: June 2014

AbstractSurfactant‐enhanced remediation (SER) is one of the most effective remediation methods for polycyclic aromatic hydrocarbons (PAH) contaminated soils. However, mass deployment of SER has been restricted due to the shortage of the separation, recycle technology of the surfactant and its operation costs. This research mainly studied the reversibility of 2‐n‐lauryl‐1,1,3,3‐tetramethyl guanidine (DTMG) surfactant and its influence on reversible solubilization of typical PAH. Experimental results showed that the reversibility of the DTMG surfactant is excellent. The critical micellar concentration (CMC), surface tension and pH of DTMG in CO2/N2 conditions undergo reversible changes promptly. DTMG·CO2 shows a strong solubilization capacity for PAH; the apparent solubilities of the selected PAH pyrene, phenanthrene and anthracene in 4 mmol/L of DTMG·CO2 solution were about 32.4, 17.1 and 14.6 times higher than in water, respectively. The corresponding molar solubilization ratios were 5.4 × 10−3, 2.80 × 10−2 and 1.1 × 10−3, much higher than those with DTMG. More than 50 % of the PAH in surfactant solutions could be released through gas control at each surfactant concentration, and improved release efficiency was achieved at low surfactant concentrations. In brief, such results in this work introduce a facile method to meliorate the SER technology.
Micro-displacement sensor based on high sensitivity photonic crystal
Authors: Olyaee Saeed , Azizi Morteza 
Published: June 2014

Abstract
In this paper, we present a micro-displacement sensor formed by the fixed and movable photonic crystal slabs. In this sensor, a waveguide was created by changing the radius of holes rather than removing them. At a proper operating wavelength, the structure could be used as the micro-displacement sensor. The results revealed that the micro-displacement sensor had a sensitivity of 3.6 μm−1, Q-factor was nearly 180, and the sensing range was 0.0 μm–0.5 μm. The properties of the micro-displacement sensor are also analyzed theoretically and verified using the finite-difference time-domain (FDTD) method carried out using the software (Rsoft).
The Impact of Diagnostic Imaging Wait Times on the Prognosis of Lung Cancer
Authors: Byrne Suzanne C. , Barrett Brendan , Bhatia Rick 
Published: June 2014

Objective This study was performed to determine whether gaps in patient flow from initial lung imaging to computed tomography (CT) guided lung biopsy in patients with non–small cell lung cancer (NSCLC) was associated with a change in tumour size, stage, and thus prognosis. Methods All patients who had a CT-guided lung biopsy in 2009 (phase I) and in 2011 (phase II) with a pathologic diagnosis of primary lung cancer (NSCLC) at Eastern Health, Newfoundland, were identified. Dates of initial abnormal imaging, confirmatory CT (if performed), and CT-guided biopsy were recorded, along with tumour size and resulting T stage at each time point. In 2010, wait times for diagnostic imaging at Eastern Health were reduced. The stage and prognosis of NSCLC in 2009 was compared with 2011. Results In phase 1, there was a statistically significant increase in tumour size (mean difference, 0.67 cm; P < .0001) and stage ( P < .0001) from initial image to biopsy. There was a moderate correlation between the time (in days) between the images and change in size ( r = 0.33, P = .008) or stage ( r = 0.26, P = .036). In phase II, the median wait time from initial imaging to confirmatory CT was reduced to 7.5 days (from 19 days). At this reduced wait time, there was no statistically significant increase in tumour size (mean difference, 0.02; P > .05) or stage ( P > .05) from initial imaging to confirmatory CT. Conclusions Delays in patient flow through diagnostic imaging resulted in an increase in tumour size and stage, with a negative impact on prognosis of NSCLC. This information contributed to the hiring of additional CT technologists and extended CT hours to decrease the wait time for diagnostic imaging. With reduced wait times, the prognosis of NSCLC was not adversely impacted as patients navigated through diagnostic imaging.
“Share and scare”: Solving the communication dilemma of early adopters with a high need for uniqueness
Authors: Moldovan Sarit , Steinhart Yael , Ofen Shlomit 
Published: June 2014

AbstractEarly adopters are considered essential to new product success due to their role in encouraging others to adopt. In this paper, we show that this may not always be true. Early adopters with a high need for uniqueness may experience a communication dilemma of whether or not to communicate about innovations they adopt. The dilemma derives from the clash between their need to flaunt the innovation they adopted and their desire to preserve their uniqueness by preventing imitation by others. We suggest that this dilemma might be resolved by a “share and scare” strategy, in which early adopters share information about their adoption with others yet scare them out of adopting it. In a series of four studies, we demonstrate early adopters' communication dilemma, the “share and scare” strategy, and three moderators that confirm our theory.
The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition
Authors: Ardini Elena , Bosotti Roberta , Borgia Andrea Lombardi , De Ponti Cristina , Somaschini Alessio , Cammarota Rosaria , Amboldi Nadia , Raddrizzani Laura , Milani Andrea , Magnaghi Paola , Ballinari Dario , Casero Daniele , Gasparri Fabio , Banfi Patrizia , Avanzi Nilla , Saccardo Maria B. , Alzani Rachele , Bandiera Tiziano , Felder Eduard , Donati Daniele , Pesenti Enrico , Sartore-Bianchi Andrea , Gambacorta Marcello , Pierotti Marco A. , Siena Salvatore , Veronese Silvio , Galvani Arturo , Isacchi Antonella 
Published: June 2014

The NTRK1 gene encodes Tropomyosin‐related kinase A (TRKA), the high‐affinity Nerve Growth Factor Receptor. NTRK1 was originally isolated from a colorectal carcinoma (CRC) sample as component of a somatic rearrangement (TPM3‐NTRK1) resulting in expression of the oncogenic chimeric protein TPM3‐TRKA, but there has been no subsequent report regarding the relevance of this oncogene in CRC. The KM12 human CRC cell line expresses the chimeric TPM3‐TRKA protein and is hypersensitive to TRKA kinase inhibition. We report the detailed characterization of the TPM3‐NTRK1 genomic rearrangement in KM12 cells and through a cellular screening approach, the identification of NMS‐P626, a novel highly potent and selective TRKA inhibitor. NMS‐P626 suppressed TPM3‐TRKA phosphorylation and downstream signaling in KM12 cells and showed remarkable antitumor activity in mice bearing KM12 tumors.Finally, using quantitative reverse transcriptase PCR and immunohistochemistry (IHC) we identified the TPM3‐NTRK1 rearrangement in a CRC clinical sample, therefore suggesting that this chromosomal translocation is indeed a low frequency recurring event in CRC and that such patients might benefit from therapy with TRKA kinase inhibitors.
Family-friendly benefits?
Authors: Ferrer Ana , Gagné Lynda 
Published: June 2014

AbstractData from the Canadian Workplace and Employee Survey (1999–2002) is used to assess the take-up of family-friendly benefits provided by employers. We distinguish benefit availability from the actual use of benefits and are able to account for worker selection into firms. We find that selection is important to understand the take-up of family-friendly benefits and that there is little difference between genders regarding benefit use. Overall, it seems that some family-friendly benefits (like flexible time) are relatively little help in the management of work-family conflict, while others (like childcare or eldercare) are unavailable to those who would benefit from them the most.
Ecophysiological Adaptations of the Lichen Genera Pseudocyphellaria and Sticta to South Temperate Rainforests
Authors: Green T.G.A. , Lange O. L. 
Published: June 2014

AbstractTemperate rainforests are a poorly researched habitat with respect to lichen ecophysiology in comparison to desert and polar regions. The evergreen, broadleaf forests provide a dim, moist environment that is relatively stable throughout the year. Lichens are abundant in both quantity and species diversity with the large foliose genera Sticta and Pseudocyphellaria normally being dominant, visually and in terms of biomass. These lichens exhibit a great diversity of both form and habitat range. Physiological and morphological adaptation has also been demonstrated. Pseudocyphellaria dissimilis shows changes in thallus water storage capacity with evaporative demand and is also highly shade-adapted. The species has the lowest light saturation and compensation values for photosynthesis yet known for lichens (20 and 1-μmol m−2s−1, PAR, respectively). Unexpectedly it is also highly desiccation-sensitive with some thalli being killed after only 20 h exposure to 15% relative humidity. Photobiont versatility is also a feature of these genera. Photosymbiodemes occur, i.e. a single thallus containing both green algal and cyanobacterial sectors. Because the different sectors have the same fungal partner and grow in the same habitat, it is possible to investigate whether particular physiological traits are photobiont determined. The ability to recover photosynthetic activity in humid air is confined to thalli with green algal photobionts whilst the inability of thalli containing cyanobacterial photobionts to tolerate high light stress may be related to their lack of a protective xanthophyll cycle.