bluuebunny/crossref_metadata_2025_split huggingface dataset:
High dietary advanced glycation end products (dAGEs) intake is associated with obesity risk in college students
Authors: Kılınç Gül Eda , Güleç Atila 
Published: August 2024

Purpose
This study aims to evaluate the relationship between the estimated levels of diet advanced glycation end products (dAGEs) intake and obesity in university students.

Design/methodology/approach
This cross-sectional study included 301 university students aged 18–30 years. dAGEs was estimated using a food frequency questionnaire, for 549 routinely consumed food items and were reported by dividing total energy intake. Dietary intake and sociodemographic data were collected using validated questionnaires, and the anthropometric characteristics were measured. The relationship between anthropometric measurements and dAGEs intake was examined by binary logistic regression.

Findings
A total of 43.2% of the participants had high levels of dAGEs. A significant decreasing trend was found in the percentage of carbohydrate intake compared to the increasing trend in dAGEs consumption (p = 0.005). The percentage of fat intake and meat consumption were significantly higher in participants with the highest consumption, compared with the lowest consumption of dAGEs (p = 0.006). According to the dAGEs classification of participants, body mass index, waist circumference and energy intake were found to be significantly related in all model groups. Accordingly, the increase in body mass index, waist circumference and energy intake were determined as a risk factor in those with high dAGEs intakes.

Originality/value
The findings of this study emphasized that higher intake of dAGEs was associated with an increased risk of obesity parameters in college students.
Exploring the role of additive manufacturing in the prosthetic supply chain: qualitative evidence
Authors: Al-Masa’fah Wasan , Abushaikha Ismail , Bwaliez Omar M. 
Published: August 2024

PurposeThis study aims to evaluate the enhancement in prosthetic supply chain capabilities resulting from the implementation of additive manufacturing (AM) technologies. The study presents an emerging model outlining the key areas that undergo changes when integrating 3D printing technologies into the prosthetic supply chain.Design/methodology/approachEmploying a qualitative approach, data were collected through field observations and 31 in-depth interviews conducted within various Jordanian organizations associated with the prosthetic industry and 3D printing technologies.FindingsThe findings suggest that the adoption of 3D printing technologies improves the prosthetic supply chain’s capabilities in terms of customization, responsiveness, innovation, environmental sustainability, cost minimization and patient empowerment. The study sheds light on the specific areas affected in the prosthetic supply chain following the adoption of 3D printing technologies, emphasizing the overall improvement in supply chain capabilities within the prosthetic industry.Practical implicationsThis study provides recommendations for governmental bodies and prosthetic organizations to maximize the benefits derived from the use of 3D printing technologies.Originality/valueThis study contributes as the first of its kind in exploring the impact of 3D printing technology adoption in the Jordanian prosthetic industry, elucidating the effects on the supply chain and identifying challenges for decision-makers in an emerging market context.
‘I feel like they understand me a bit more’: The experiences of young people with borderline personality disorder following their parents taking part in a mentalisation‐based intervention for parents and carers (MBT‐FACTS)
Authors: Benetti Celeste , Whitehead Richard , Hopkins Liza 
Published: August 2024

AbstractBorderline Personality Disorder (BPD) is a distressing mental illness that is overrepresented in adolescents and youth and which was previously thought difficult to treat. Families and carers of those with BPD can also experience high levels of distress and burden and can struggle in their support of those with BPD. The Families and Carers Training and Support (FACTS) program is an innovative skills and education program for family members and carers of someone with BPD informed by mentalisation‐based treatment (MBT) principles. To address a gap in the research, the present study aimed to see what effect, if any, a carer‐focused intervention has on the young people with BPD themselves. To assess this, interviews were conducted with eight young people whose family members participated in the program. Overall, the young people felt there had been positive changes during and after their family members' participation in the program. They felt the communication with their family members improved; they also felt more understood and that they had more space and freedom in the home and that the tension in the household decreased. Additionally, several young people felt they would have liked to be more involved in the process and to take part in the program alongside their family members. The findings indicate that interventions focusing on building understanding and self‐awareness in carers of those BPD can be important in ameliorating the challenging impact of BPD on young people and their families.
‘We're trying to get out of here, that's what we're doing’: A Bourdieusian examination of ‘choice’ in the National Disability Insurance Scheme
Authors: Dearn Elroy , Ramcharan Paul 
Published: August 2024

AbstractThe notion of choice underpinning Australia's National Disability Insurance Scheme (NDIS) has its origin in neoliberal assumptions about the inherent value of market choice in human services reform and in the disability movement's advocacy for the right to self‐determination. Little is known about how people in institutional settings experience choice in the NDIS context. Based on a critical ethnographic study, this article explores the choices made by 12 people with psychosocial disability living in two Victorian supported residential services (SRS). The study found that despite the goal of most participants being to move into independent accommodation, 2 years after the start of the roll‐out of the NDIS, most participants were still living in SRS. Adopting a Bourdieusian conceptual framework, we show that the choices participants made were constrained by the institutional field in which they were living, their low capitals, and their relative powerlessness. This novel application of the concepts of field, habitus, and capitals in the NDIS context has implications for debates about the impact of marketisation and personalisation on individuals with limited agency. The findings have implications for policy and practice in other institutional settings and jurisdictions where public service delivery is framed around the notion of choice.Points for practitioners
This research shows that a key choice for residents with psychosocial disability living in SRS was to move into independent housing. However, choice over their housing goals was constrained by living in an institutional setting and their relative powerlessness.
Residents in these settings and NDIS participants living in other segregated institutional settings will need independent housing and living navigators if they are to find pathways into independent housing.
Antecedents and outcomes of enabling HR practices: The paradox of consistency and flexibility
Authors: Pak Jongwook , Heidarian Ghaleh Hossein , Ma Zhenzhong , Akhtar Muhammad Naseer 
Published: August 2024

AbstractReconciling competing demands for consistent HR implementation and providing individualized supervisor support to employees has always been a challenge in strategic human resource management. Given that there is burgeoning evidence that frontline managers (FLMs) are at the center of HR implementation, we examine how the organization helps FLMs reconcile demands for consistent HR implementation and deliver individualized support to those under their supervision. With the data from 181 FLMs and 311 employees reported to these FLMs, we find that FLMs' perceived enabling HR practices mediate the relationship between high‐performance work systems and FLMs' willingness to be flexible (WTBF). Furthermore, WTBF mediates the relationship between FLMs' perceived enabling HR practices and consistent HR implementation and between FLMs' perceived enabling HR practices and employees' individualized support. Our study offers new insights by highlighting that an effective HR system is not merely improving FLMs' HR competency and knowledge but capturing FLMs' WTBF in carrying on a broad range of HR tasks. Furthermore, our study provides an expanded and novel understanding that FLMs will likely face two opposite HR tasks that coexist and should be dealt with simultaneously as a pair. We then discuss the theoretical and practical implications of our findings and suggest future research directions.
The impact of COVID‐19‐related national lockdowns on alcohol‐related traffic collisions, injuries, and fatalities in Lithuania
Authors: Lange Shannon , Jiang Huan , Miščikienė Laura , Tran Alexander , Štelemėkas Mindaugas , Rehm Jürgen 
Published: August 2024

AbstractBackgroundThe national lockdowns that occurred all over the world in response to the Coronavirus Disease 2019 (COVID‐19) pandemic have been found to have impacted alcohol use. The aim was to evaluate the impact of COVID‐19‐related national lockdowns on alcohol‐related traffic collisions, injuries, and fatalities in Lithuania.MethodsUsing monthly data from the Lithuanian Road Police Service for January 2004 to December 2022, we performed interrupted time‐series analyses using a generalized additive model to evaluate the impact of COVID‐19‐related national lockdowns on alcohol‐related traffic collisions, injuries, and fatalities. In Lithuania, the COVID‐19‐related lockdowns occurred from March 2020 to June 2020 and from November 2020 to June 2021.ResultsAlthough overall rates for traffic collisions and injuries decreased during the COVID‐19‐related lockdowns in Lithuania, these lockdowns were associated with a 3.21% (95% CI: 1.19%, 5.23%) increase in the relative proportion of alcohol‐related traffic collisions and a 2.46% (95% CI: 0.12%, 4.80%) increase in the relative proportion of alcohol‐related traffic injuries. The association between the lockdowns and alcohol‐related traffic fatalities was not statistically significant.ConclusionThe COVID‐19‐related national lockdowns in Lithuania were associated with a decrease in the overall rate of traffic collisions and injuries, but an increase in the relative proportion of alcohol‐related traffic collisions and injuries.
Unraveling the smokescreen of ESG disclosure debate: Shedding light on excessive ESG disclosure and economic risk
Authors: Khanchel Imen , Lassoued Naima 
Published: August 2024

AbstractThis paper investigates the correlation between excessive ESG disclosure and economic risk, measured through the cost of capital. We analyze a sample comprising 430 S&P 500 US firms over 12 years, from 2011 to 2022. Our findings show that excessive ESG disclosure is associated with a reduction in the cost of capital. Specifically, the environmental and social dimensions of ESG disclosure exhibit explanatory power in decreasing the cost of capital, with the environmental dimension demonstrating particularly strong influence. Conversely, excessive governance disclosure shows no significant impact. Additionally, our study shows that CSR assurance serves as a negative moderator in the relationship between excessive ESG disclosure (including overall excessive ESG score, and environmental and social dimensions) and economic risk.
Are companies ethically justified in offering nonmedical egg freezing as an employee benefit?
Authors: Espinosa‐Herrera Alejandro , Pietrini‐Sanchez Maria‐Jose 
Published: August 2024

AbstractAll over the world, many companies are including oocyte cryopreservation for nonmedical reasons, also popularly known as nonmedical egg freezing (NMEF), within their employee benefits packages. However, it is important to ask whether companies are ethically justified in offering NMEF as a benefit for their employees. The inclusion of NMEF within companies' employee benefits packages could be ethically justified in two ways. On the one hand, company‐sponsored NMEF can serve as a strategy to mitigate or eliminate gender inequalities in the workplace, such as female underrepresentation in positions of authority and leadership and the so‐called work/motherhood conflict. On the other hand, company‐sponsored NMEF can be a means to expand women's reproductive autonomy by making egg freezing accessible to those women who are not able to afford it otherwise. This article calls into question these ethical justifications. We argue that by offering NMEF as an employee benefit, companies maintain current workplace inequalities and impose an option for women with multiple risks and externalities. Therefore, companies' offering of NMEF benefits cannot be ethically justified. Furthermore, we argue that companies that offer NMEF benefits incur fiduciary responsibilities related to the physiological, emotional, psychological, and financial costs of the use of company‐sponsored NMEF.
Off‐target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
Authors: Lagunas‐Rangel Francisco Alejandro , Liepinsh Edgars , Fredriksson Robert , Alsehli Ahmed M. , Williams Michael J. , Dambrova Maija , Jönsson Jörgen , Schiöth Helgi B. 
Published: August 2024

AbstractStatins are one of the most important classes of drugs. In this analytical review, we elucidate the intricate molecular mechanisms and toxicological rationale regarding both the on‐ (targeting 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase [HMGCR]) and off‐target effects of statins. Statins interact with a number of membrane kinases, such as epidermal growth factor receptor (EGFR), erb‐b2 receptor tyrosine kinase 2 (HER2) and MET proto‐oncogene, receptor tyrosine kinase (MET), as well as cytosolic kinases, such as SRC proto‐oncogene, non‐receptor tyrosine kinase (Src) and show inhibitory activity at nanomolar concentrations. In addition, they interact with calcium ATPases and peroxisome proliferator‐activated receptor α (PPARα/NR1C1) at higher concentrations. Statins interact with mitochondrial complexes III and IV, and their inhibition of coenzyme Q10 synthesis also impairs the functioning of complexes I and II. Statins act as inhibitors of kinases, calcium ATPases and mitochondrial complexes, while activating PPARα. These off‐target effects likely contribute to the side effects observed in patients undergoing statin therapy, including musculoskeletal symptoms and hepatic effects. Interestingly, some off‐target effects of statins could also be the cause of favourable outcomes, relating to repurposing statins in conditions such as inflammatory disorders and cancer.
Prediction of Drug‐Induced Liver Injury: From Molecular Physicochemical Properties and Scaffold Architectures to Machine Learning Approaches
Authors: Zhao Yulong , Zhang Zhoudong , Kong Xiaotian , Wang Kai , Wang Yaxuan , Jia Jie , Li Huanqiu , Tian Sheng 
Published: August 2024

ABSTRACTThe process of developing new drugs is widely acknowledged as being time‐intensive and requiring substantial financial investment. Despite ongoing efforts to reduce time and expenses in drug development, ensuring medication safety remains an urgent problem. One of the major problems involved in drug development is hepatotoxicity, specifically known as drug‐induced liver injury (DILI). The popularity of new drugs often poses a significant barrier during development and frequently leads to their recall after launch. In silico methods have many advantages compared with traditional in vivo and in vitro assays. To establish a more precise and reliable prediction model, it is necessary to utilize an extensive and high‐quality database consisting of information on drug molecule properties and structural patterns. In addition, we should also carefully select appropriate molecular descriptors that can be used to accurately depict compound characteristics. The aim of this study was to conduct a comprehensive investigation into the prediction of DILI. First, we conducted a comparative analysis of the physicochemical properties of extensively well‐prepared DILI‐positive and DILI‐negative compounds. Then, we used classic substructure dissection methods to identify structural pattern differences between these two different types of chemical molecules. These findings indicate that it is not feasible to establish property or substructure‐based rules for distinguishing between DILI‐positive and DILI‐negative compounds. Finally, we developed quantitative classification models for predicting DILI using the naïve Bayes classifier (NBC) and recursive partitioning (RP) machine learning techniques. The optimal DILI prediction model was obtained using NBC, which combines 21 physicochemical properties, the VolSurf descriptors and the LCFP_10 fingerprint set. This model achieved a global accuracy (GA) of 0.855 and an area under the curve (AUC) of 0.704 for the training set, while the corresponding values were 0.619 and 0.674 for the test set, respectively. Moreover, indicative substructural fragments favorable or unfavorable for DILI were identified from the best naïve Bayesian classification model. These findings may help prioritize lead compounds in the early stage of drug development pipelines.
Global, Regional and National Burden of Paediatric Atopic Dermatitis: A Trend and Geographic Inequalities Analysis
Authors: Cao Xueshan , Wang Minmin , Zhou Mengge , Mi Yuanqi , Guo Qi , Fan Yanbin , Guo Yang 
Published: August 2024

ABSTRACTBackgroundAtopic dermatitis (AD) is a common chronic skin disorder in children. We aimed to investigate trends and regional disparities of burden in paediatric AD at global, regional and national levels, and to explore potential associated factors.MethodsBased on data from Global Burden of Disease study 2019, we assessed trends in burden of AD aged <19 years from 1990 to 2019, including prevalent and incident cases, age‐standardised prevalence and age‐standardised incidence. For potential associated factors, correlations of above trends and indexes of socio‐economic status (sociodemographic index, SDI) and health service coverage (universal health coverage index, UHCI) were evaluated. We conducted decomposition analysis to understand the net contribution of population‐level factors and their contribution proportions on changes of prevalent and incident cases, including age structure, population change and epidemiological change.ResultsGlobal prevalent and incident cases of paediatric AD increased by about 5.7 and 0.7 million between 1990 and 2019, respectively. Global age‐standardised prevalence and incidence decreased by −0.17% (−0.19% to −0.16%) and −0.12% (−0.13% to −0.11%) per year from 1990 to 2019, respectively. Regionally, the highest increase of prevalent and incident cases was in low SDI region (by 96.77% and 84.85%); the highest decrease of age‐standardised prevalence and incidence was in high SDI regions (by −0.20% and −0.27% per year). The correlation analyses identified significant negative correlations between trends and SDI and UHCI. Population change was a major driver of case rise; epidemiological change and age structure showed negative impact of case rise. Regional disparities in contribution of three population‐level factors were seen, including net contribution direction (positive or negative) and contribution proportion levels.ConclusionGlobal paediatric AD case numbers increased, primarily due to population growth. Prevalence and incidence decreased slightly. Geographic inequalities were seen. Developing region‐specific strategies targeting potential factors is essential to reduce paediatric AD burden.
Pandemic of sensitivity to acrylate containing nail cosmetic among young Israeli women? Result of patch testing 2‐hydroxyethyl methacrylate in the European baseline series
Authors: Hilewitz D. , Trattner A. , Reiter O. , Uvaidov V. , Noyman Y. , Solomon Cohen E. , Hackett A. , Mimouni D. , Snast I. 
Published: August 2024

AbstractBackground2‐Hydroxyethyl methacrylate (HEMA) was added into the European baseline series (EBS) in 2019. There is limited data regarding the frequency, relevance, and sources of exposure to HEMA.ObjectivesTo investigate the frequency and clinical relevance of positive reactions to HEMA in the EBS in Israel, and explore sources of exposure.MethodsRetrospective cohort study that included all patients who underwent patch testing with the EBS in a tertiary center in Israel between 2020 and 2023. Positive reactions to HEMA were stratified by sex, six age groups, and year of study. Sources of exposure to HEMA as well as occupational data were recorded.ResultsA total of 1671 consecutive patients underwent HEMA patch testing, with 135 (8.1%) showing positive reactions to HEMA (130 females, 5 males). The prevalence in women (11.0%) was significantly higher compared to men (1.0%) (p < 0.001). Stratification by age and sex revealed the highest frequency of HEMA sensitivity of 16.7% among women younger than 30 years of age, with odds ratio of 2.3 (95%CI: 1.6–3.3, p < 0.001) compared to older women. There was an increase in frequency among women between the years 2022 and 2023 when compared to 2020–2021 (OR 1.7, 95%CI: 1.5–2.1, p < 0.01) attributable to COVID‐19 pandemic and social restrictions. Among men the frequency fluctuations over the study period and age categories were nonsignificant. 111 (84%) were judged to be of clinical relevance and nail cosmetics was responsible for 95% of them. Of 111 patients with relevant reaction (110 females, 1 males), 20 (18%) had occupational contact dermatitis (18 nails stylists, 2 dentists). Other culprit products included sanitary pads (n = 4), medical adhesives (n = 3), and paints (n = 2).ConclusionWe report the highest frequency of HEMA sensitivity to date of 8.1%, that was most common among young women and in vast majority of cases was attributable to nail cosmetics. Our findings reflect the popularity of nail cosmetics in Israel as well as the global trend of increasing sensitivity to (meth)acrylates.
The effect of expansion of nurse practitioner scope of practice on early COVID‐19 deaths
Authors: Chung Bobby W. , Trudeau Noah J. 
Published: August 2024

AbstractPublic safety is often used as an argument against expanding scope of practice (SOP) for nurse practitioners, despite the benefit of filling unmet health care demand. As a response to the COVID‐19 Pandemic, some states expanded SOP for nurse practitioners to accommodate the unprecedented healthcare challenge. We analyze the effect of the expansion of SOP on daily COVID‐19‐related mortality, exploiting the quasi‐random state policy changes at the beginning of the COVID‐19 pandemic. Checking different model specifications, we do not find evidence that expanding SOP for nurse practitioners during the pandemic causes adverse effects on patients measured by COVID‐19 mortality.
Appropriability, institutions, and welfare in a Tullock contest
Authors: Lahkar Ratul 
Published: August 2024

AbstractWe model institutional development through Tullock contests. We define appropriability in terms of the extent to which high effort can enable agents to acquire control of the resource in the contest. At low appropriability, all agents share the resource equitably at the Nash equilibrium. Hence, institutions are inclusive and have a high aggregate payoff and equality. Social welfare is high. However, with high appropriability, the strongest agents exclude others from the resource. Institutions are then exclusive. Excessive rent seeking by the strongest agents reduces payoffs but increases inequality. Social welfare is low. We also establish the robustness of the Nash equilibrium under the best response dynamic.