bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of yeast-enriched functionalized canola meal supplementation on apparent total tract macronutrient digestibility and fecal characteristics, fecal microbiota, and immune function of healthy adult dogs
Authors: De La Guardia-Hidrogo Vanessa M , Soto-Diaz Katiria , Rummell Lindsey M , Valizadegan Negin , Fields Christopher J , Steelman Andrew J , Swanson Kelly S 
Published: August 2024

Abstract
Brewer’s dried yeast has a high nutritional value and has long been utilized by the animal feed industry as a source of protein, B-complex vitamins, and minerals. Brewer’s dried yeast is also rich in bioactive compounds and may thereby be used as a functional ingredient, providing benefits beyond that of its nutrient content. Canola meal is a high-fiber ingredient that also has unique properties, especially when it is wetted and dried using a proprietary drying system that creates a “functionalized” canola meal. The objective of this experiment was to evaluate the effects of a yeast-enriched functionalized canola meal (FCM) on apparent total tract digestibility (ATTD) and the fecal quality, metabolite concentrations, and microbiota populations, and immune function of healthy adult dogs. Twelve adult female beagles (body weight [BW] = 7.6 ± 0.7 kg; age = 5.8 ± 1.3) were used in a replicated 4 × 4 Latin square design with 28-d periods. Each experimental period consisted of a 22-d adaptation phase, 5 d of total and fresh fecal collection, and blood collection on the last day. To start, all dogs were fed a basal diet to maintain BW for 14 d. Following fecal and blood collections at baseline (−1 d) to confirm health status, experimental periods began testing the following dietary treatments using a Latin square design experiment: 1) FCM only (no yeast inclusion), 2) FCM + low yeast dose, 3) FCM + medium yeast dose, and 4) FCM + high yeast dose. All treatments were top-dressed onto the basal diet at a rate estimated to be 1% of daily intake (as-is basis). Statistical analysis was performed using the PROC MIXED procedure of SAS with the main effect of treatment and the random effect of dog. Significance was declared at P ≤ 0.05, and trends reported if 0.05 &lt; P ≤ 0.10. Supplementation with yeast-enriched FCM had no significant effect on the ATTD of macronutrients or energy or the fecal characteristics, metabolite concentrations, and microbiota populations of dogs. Additionally, no significant differences were observed in circulating immune cell counts or response to Toll-like receptor agonists among treatments. Our results suggest that the yeast-enriched FCM could be included in canine diets without negatively affecting stool quality, fecal metabolite concentrations, or ATTD. Further research is necessary to determine the effective dose of yeast-enriched FCM, potential mechanisms of action, and other potential implications it has on canine health.
Landscape analysis of environmental data sources for linkage with SEER cancer patients database
Authors: Tatalovich Zaria , Chtourou Amina , Zhu Li , Dellavalle Curt , Hanson Heidi A , Henry Kevin A , Penberthy Lynne 
Published: August 2024

Abstract
One of the challenges associated with understanding environmental impacts on cancer risk and outcomes is estimating potential exposures of individuals diagnosed with cancer to adverse environmental conditions over the life course. Historically, this has been partly due to the lack of reliable measures of cancer patients’ potential environmental exposures before a cancer diagnosis. The emerging sources of cancer-related spatiotemporal environmental data and residential history information, coupled with novel technologies for data extraction and linkage, present an opportunity to integrate these data into the existing cancer surveillance data infrastructure, thereby facilitating more comprehensive assessment of cancer risk and outcomes. In this paper, we performed a landscape analysis of the available environmental data sources that could be linked to historical residential address information of cancer patients’ records collected by the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program. The objective is to enable researchers to use these data to assess potential exposures at the time of cancer initiation through the time of diagnosis and even after diagnosis. The paper addresses the challenges associated with data collection and completeness at various spatial and temporal scales, as well as opportunities and directions for future research.
Anti-asparaginyl-tRNA synthetase antibody-positive pneumonitis in a patient with immune checkpoint inhibitor treatment: A case report and literature review
Authors: Oda Nobuhiro , Koguchi Okuto , Kontani Hiroki , Hayashi Jun , Hazue Ryo , Oyama Yu , Rokutanda Ryo 
Published: August 2024

ABSTRACT
In recent years, the use of immune checkpoint inhibitors (ICIS) has increased and there have been case reports of anti-aminoacyl-tRNA synthetase (anti-ARS) antibody syndrome during ICI treatment. However, these cases are limited, and their clinical characteristics are not fully understood. We report the first case of anti-ARS antibody syndrome with asparaginyl-tRNA synthetase antibody during ICI therapy. This report presents our case, along with a literature review of other anti-ARS antibody syndrome cases that developed after ICI use, discussing their clinical characteristics and possible mechanisms of onset. Considering the widespread use of ICIs in cancer therapy, we should be aware of anti-ARS antibody syndrome that develops during the use of ICIs.
Defining neuroblastoma: From origin to precision medicine
Authors: Sainero-Alcolado Lourdes , Sjöberg Bexelius Tomas , Santopolo Giuseppe , Yuan Ye , Liaño-Pons Judit , Arsenian-Henriksson Marie 
Published: August 2024

Abstract
Neuroblastoma (NB), a heterogenous pediatric tumor of the sympathetic nervous system, is the most common and deadly extracranial solid malignancy diagnosed in infants. Numerous efforts have been invested in understanding its origin and in development of novel curative targeted therapies. Here, we summarize the recent advances in the identification of the cell of origin and the genetic alterations occurring during development that contribute to NB. We discuss current treatment regimens, present and future directions for the identification of novel therapeutic metabolic targets, differentiation agents, as well as personalized combinatory therapies as potential approaches for improving the survival and quality of life of children with NB.
Dosimetric comparison of hippocampal-sparing technologies in patients with low-grade glioma
Authors: Williamson Aoife , Houston Peter , Paterson Jennifer , Chalmers Anthony J , McLoone Philip , Fullerton Natasha , Foo Sin Yee , James Allan , Nowicki Stefan 
Published: August 2024

Abstract

Background
Radiotherapy (RT) plays an integral role in the management of low-grade gliomas (LGG). Late toxicity from RT can cause progressive neurocognitive dysfunction. Radiation-induced damage to the hippocampus (HCP) plays a considerable role in memory decline. Advancements in photon planning software have resulted in the development of multi-criteria optimization (MCO) and HyperArc technologies which may improve HCP sparing while maintaining planning target volume (PTV) target coverage.

Methods
Three planning methods for hippocampal sparing (HS) were compared, volumetric modulated arc therapy (VMAT) without HS (VMAT_noHS), VMAT with HS (VMAT_HS), MCO with HS (MCO_HS), and HyperArc with HS (HyperArc_HS).

Results
Twenty-five patients were identified. The contralateral HCP was spared in 16 patients and bilateral HCP in 9 patients with superiorly located tumors. All 3 HS planning techniques showed significant reductions in dose to the spared HCP in contralateral cases but only VMAT_HS and MCO_HS achieved this in bilateral cases (P &lt; .008). Only MCO_HS was superior to VMAT_HS in lowering the dose to both contralateral HCP and bilateral HCP in all measured metrics (P &lt; .008). PTV and OAR (organ at risk) dose constraints were achieved for all plans.

Conclusions
This retrospective dosimetric study demonstrated the feasibility of HS for low-grade glioma. All 3 HS planning techniques achieved significant dose reductions to the spared contralateral hippocampus, but only MCO_HS and VMAT_HS achieved this in bilateral cases. MCO was superior to other planning techniques for sparing both bilateral and contralateral hippocampi.
The Effects of Combustible Cigarettes and Electronic Nicotine Delivery Systems on Immune Cell-Driven Inflammation and Mucosal Healing in Ulcerative Colitis
Authors: Kastratovic Nikolina , Markovic Vladimir , Arsenijevic Aleksandar , Volarevic Ana , Zdravkovic Natasa , Zdravkovic Marija , Brankovic Marija , Gmizic Tijana , Harrell Carl Randall , Jakovljevic Vladimir , Djonov Valentin , Volarevic Vladislav 
Published: August 2024

Abstract

Introduction
The effects of combustible cigarettes (CCs) and electronic nicotine delivery systems (ENDS) on immune cell-driven colon inflammation and intestinal healing of patients with ulcerative colitis (UC) are still unknown and, therefore, were examined in this study.

Aims and Methods
Intracellular staining and flow cytometry analysis of immune cells isolated from UC patients who used ENDS (UCENDS), CCs (UCCC) and who were nonsmokers (UCAIR) were performed to elucidate cellular mechanisms which were responsible for CCs and ENDS-dependent modulation of immune response during UC progression. Additionally, dextran sulfate sodium (DSS)-colitis was induced in ENDS/CC/air-exposed mice (DSSENDS/ DSSCC/DSSAIR groups) to support clinical findings.

Results
Significantly increased number of immunosuppressive, IL-10, TGF-β, and IL-35-producing, FoxP3-expressing CD3 + CD4 + T regulatory cells (Tregs) was observed in the blood of UCENDS patients while the reduced presence of inflammatory, TNF-α and IFN-γ-producing, Tbx21-expressing CD3 + CD4 + Th1, IL-4-producing Gata3-expresing Th2 and IL-17, IL-22-producing, RORγT, IL-23R-expressing Th17 cells were noticed in the blood of UCCC patients. Exposure to either CCs or ENDS was associated with enhanced mucosal healing, ameliorated spontaneous recovery, and improved survival of DSS-treated mice. An expansion of immunosuppressive cells (IL-10-producing tolerogenic CD11c + dendritic cells, alternatively activated CD206, Arginase 1-expressing, IL-10-producing F4/80 + macrophages, IL-10-producing FoxP3-expressing Tregs) was noticed in the colons of DSSENDS–treated mice, while reduced number of inflammatory, IL-17- and IL-4-producing T lymphocytes was observed in the colons of DSSCC-compared to DSSAIR-treated mice.

Conclusions
Despite different mechanisms of action, both ENDS and CCs attenuated ongoing colon inflammation, enhanced healing, and ameliorated recovery of injured intestines of DSS-treated mice and UC patients.

Implications
This is the first study that compared the effects of CCs and ENDS on immune cells of patients suffering from UC, providing new information about molecular and cellular mechanisms which were responsible for ENDS and CCs-dependent modulation of immune cell-driven colon injury and inflammation. Obtained results showed that both ENDS and CCs had the capacity to attenuate detrimental immune response, enhance healing, and ameliorate recovery of injured intestines.
The Protective Effect of Octanoic Acid on Sepsis: A Review
Authors: Tang Jiabao , Li Xiaohua , Li Wei , Cao Chun 
Published: August 2024

Abstract
Sepsis, a systemic inflammation that occurs in response to a bacterial infection, is a significant medical challenge. Research conducted over the past decade has indicated strong associations among a patient's nutritional status, the composition of their gut microbiome, and the risk, severity, and prognosis of sepsis. Octanoic acid (OA) plays a vital role in combating sepsis and has a protective effect on both animal models and human patients. In this discussion, the potential protective mechanisms of OA in sepsis, focusing on its regulation of the inflammatory response, immune system, oxidative stress, gastrointestinal microbiome and barrier function, metabolic disorders and malnutrition, as well as organ dysfunction are explored. A comprehensive understanding of the mechanisms by which OA act may pave the way for new preventive and therapeutic approaches to sepsis.
Efficacy and safety of camrelizumab, apatinib, and capecitabine combination therapy in advanced biliary tract cancer: a phase 2, nonrandomized, prospective study
Authors: Jing Chao , Bai Zhigang , Tong Kuinan , Yang Xiaobao , Liu Kun , Wu Hongwei , Zhu Jiegao , Guo Wei , Zhang Zhongtao , Deng Wei 
Published: August 2024

Abstract

Background
Biliary tract cancer (BTC) is a highly malignant tumor, with limited therapy regimens and short response duration. In this study, we aim to assess the efficacy and safety of the combination of camrelizumab, apatinib, and capecitabine as the first- or second-line treatment in patients with advanced BTC.

Methods
In this phase 2, nonrandomized, prospective study, eligible patients received camrelizumab (200 mg, d1, Q3W), apatinib (250 mg, qd, d1-d21, Q3W), and capecitabine (1000 mg/m², bid, d1-d14, Q3W) until trial discontinued. The primary endpoint was the objective response rate (ORR). The secondary endpoints were disease control rate, progression-free survival (PFS), overall survival (OS), and safety.

Results
From July 2019 to April 2023, we enrolled a total of 28 patients, of whom 14 patients were in the first-line treatment setting and 14 patients were in the second-line setting. At the data cutoff (April 30, 2023), the median follow-up duration was 18.03 months. Eight of 28 patients reached objective response (ORR: 28.57%), with an ORR of 50% and 7.1% for first-line and second-line treatment patients (P = .033). The median PFS was 6.30 months and the median OS was 12.80 months. Grade 3 or 4 adverse events (AEs) occurred in 9 (32.14%) patients, including elevated transaminase, thrombocytopenia, etc. No serious treatment-related AEs or treatment-related deaths occurred.

Conclusions
In this trial, the combination of camrelizumab, apatinib, and capecitabine showed promising antitumor activity and manageable toxicity in patients with advanced BTC, especially in the first-line setting.

Clinical Trial Registration
NCT04720131.
Growth performance and meat quality of broiler chickens fed diet containing bird eye pepper of varying proportion and sieve size
Authors: Adegoke Adeola V , Oduola Abdul-basit O , Adeyemo Adedayo A 
Published: August 2024

Abstract
This study investigated the potency of bird eye pepper (BEP) of varying proportion and sieve size on growth performance and meat quality of broiler chickens. Two hundred and forty-six 2-wk-old broiler chicks were randomly allotted to six treatment groups (basal diet (B) inclusive × 2) in a 2 × 3 factorial arrangement each replicated four times (10 × 10 × 10 × 11) in a completely randomized design. Diets containing BEP of varying proportion (0, 150, and 300 g) and sieve size (0.05 and 0.1 mm) were offered in two phases, starter (14 d) and finisher (17 d). Postfeeding, 48 birds (two per replicate) were sacrificed to further evaluate performance and assess the quality of meat produced. Result obtained indicates chicks fed 150 g BEP consumed less feed compared to 300 g BEP. Also, 0 and 150 g BEP groups had better (P &lt; 0.05) feed conversion ratio (FCR) than 300 g BEP, while 0.05 mm BEP diet improved (P &lt; 0.05) FCR as against 0.1 mm BEP. Interaction of proportion and sieve size effects of BEP increased (P &lt; 0.05) the final weight of the birds and suppressed (P &lt; 0.05) feed intake for all groups as against 300 g (0.1 mm) BEP (1,576.00 g/bird; 964.20 g/bird). Feeding 150 and 300 g BEP diets lowered (P &lt; 0.05) superoxide dismutase (SOD) production compared to 0 g BEP, while 150 g BEP diet increased (P &lt; 0.05) catalase production over 0 g BEP. Interactive effect of proportion and sieve size of BEP reduced (P &lt; 0.05) SOD production in 150 g (0.05 and 0.1 mm) BEP and 300 g (0.05 mm) BEP groups, followed by 300 g (0.1 mm) BEP group that had lower (P &lt; 0.05) SOD than both basal groups. Birds fed B + 150 g (0.05 mm) BEP diet produced more (P &lt; 0.05) catalase compared to both basal groups. Meat pH for 150 and 300 g BEP groups was significantly (P &lt; 0.05) reduced than 0 g BEP. The Hue angle corresponds with a high value (P &lt; 0.05) to 0 g BEP, while 300 g BEP showed a low value. This study has shown BEP at low concentration (150 g) screened with 0.05 and 0.1 mm sieves enhanced chick welfare, while a higher concentration (300 g) screened at 0.05 mm improved overall growth performance (endogenous antioxidant profile) at finisher phase. Broiler chickens, farmers, and meat processors will benefit from diet containing BEP screened through 0.05 mm sieve.
The Scholarship of Wellness and Mindfulness to Support First-Year Nursing Students’ Response to Stress
Authors: Strout Kelley , Schwartz-Mette Rebecca , Parsons Kayla , Sapp Maile 
Published: August 2024

Abstract
An educational innovation centered on mindfulness was developed to support the well-being of first-year nursing students at a large public university. Students participated in a week-long experiential learning program before their first semester. They then enrolled in a one-credit course that fostered well-being through research and evidence-based mindfulness practices. The course was highly ranked because of the quality of learning, environment, and theories presented, indicating that supportive wellness initiatives are acceptable and feasibility for future implementation.
October 7th Mass Casualty Attack in Israel: Injury Profiles of Hospitalized Casualties
Authors: Goldman Sharon , Lipsky Ari M. , Radimislensky Irina , Givon Adi , Almog Ofer , Benov Avi ,   Israel Trauma Group, Katorza Eldad 
Published: August 2024

Background:
On Saturday, October 7th, approximately 3000 Hamas-led terrorists infiltrated Israel’s southern border and attacked civilians and soldiers. Terrorists murdered close to 1200 people, abducted hundreds, and injured thousands. This surprise attack involved an unprecedented number of casualties. This article describes the injuries and outcomes of the hospitalized casualties.

Methods:
Hospitalized trauma casualties with an injury date of October 7 to 8, 2023, and with ICD9 E-codes E979 and E990 through E999, were extracted from the Israel National Trauma Registry. Demographic, injury, and hospital resource-use data were analyzed.

Results:
A total of 630 hospitalized casualties (277 civilians and 353 soldiers) suffered from gunshot wounds (90%), explosion-related wounds (19%), and multiple injury mechanisms (16%). The median age for civilians was 33 years (ages <1–88) and 21 years for soldiers. The most frequently injured body regions were lower (49%) and upper (42%) extremities, abdominal (28%), and thoracic (23%) injuries. Four hundred thirty-one (68%) patients underwent surgery, of which 240 within 12 hours. Over half of the severe and critical (Injury Severity Score 16+) casualties were discharged to a rehabilitation center. In-hospital mortality rate was 2.5%.

Conclusion:
Israel’s hospitals faced many challenges following the mega mass casualty incident, including the absorption, diagnosis, treatment, and rehabilitation of a massive number of casualties. Hospitals needed to immediately repurpose to provide additional imaging equipment and operating rooms. Additionally, the huge demand for rehabilitation resources necessitated immediate reorganization and transformation of existing medical facilities to accommodate the many casualties requiring rehabilitation. The injury details and outcomes from this mega mass casualty incident provide important information for planning and preparedness at local, regional, and national levels.
Identifying Risk Factors for Open Reduction in Pediatric Supracondylar Humerus Fractures
Authors: Kolac Ulas Can , Oral Melih , Sili Mazlum Veysel , Ibik Serkan , Aydinoglu Hasan Samil , Bakircioglu Sancar , Yilmaz Guney 
Published: August 2024

Background:
Supracondylar humerus fractures (SCHFs) are the most common injuires of the elbow in children, often categorized by the Gartland classification. While type 1 and 2 fractures commonly managed conservatively, type 3 and 4 fractures typically require surgical treatment. Although closed reduction and percutaneous pinning have shown success, open reduction may be required in cases where adequate reduction cannot be achieved. This study aims to identify radiological and clinical risk factors associated with transitioning from closed reduction to open reduction in Gartland type 3 and 4 SCHF in children.

Study Design and Methods:
We retrospectively analysed 159 patients operated on between 2014 and 2022 for Gartland type 3 and 4 SCHF. Parameters including age, gender, injury severity, time to surgery, neurovascular damage, medial spike angle, fracture-skin distance, medial-lateral deviation, rotation, fracture level, and Baumann angle were evaluated.

Results:
A total of 159 SCHF in children aged 3 to 12 years, classified as Gartland type 3 (106 patients, 66.6%) and type 4 (53 patients 33.4%), underwent surgical intervention. Notably, 46 patients (28.9%) initially managed with closed reduction exhibited failure, prompting the necessity for conversion to open reduction. Injury severity, lateral deviation, advanced age, low medial spike angle, and low fracture tip-to-skin distance were found to be factors that could potentially increase the need for open reduction (P<0.05). Logistic regression analysis showed that the low medial spike angle, flexion type injury, and low fracture type increased the likelihood of open surgery (P<0.05). Sex, side, duration to surgery, and Baumann angle showed no significant associations.

Conclusions:
SCHF commonly necessitate surgical intervention in children. Although the risk factors for failed closed reduction and the need for open surgery have been discussed in the literature, there is no consensus. Preoperative planning, particularly for patients with specific factors like lateral deviation, advanced age, low medial spike angle, low fracture-to-skin distance and high injury severity, should consider potential open surgery requirements.

Level of Evidence:
Level III