bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zedoary oil (Ezhu You) inhibits proliferation of AGS cells
Authors: Shi Hailian , Tan Bao , Ji Guang , Lu Lan , Cao Aili , Shi Songshan , Xie Jianqun 
Published: June 2013

Abstract

Background
Zedoary (Curcumae Rhizoma, Ezhu), a Chinese medicinal herb, has been reported to show anticancer activity. This study aims to investigate the effect of zedoary oil (Ezhu You) on the proliferation of AGS cells which is one gastric cancer cell line.

Methods
The main ingredients of the herb were detected by GC-MS for herbal quality control. Cell viability was measured by MTT assay and cell proliferation was investigated by immunocytochemical staining for proliferating cell nuclear antigen (PCNA) protein. In addition, the cell cycle distributions were detected by flow cytometry with propidium iodine (PI) staining and the apoptosis rates were evaluated by flow cytometry with annexin V/PI double-staining. The morphological changes associated with apoptosis were observed by Hoechst 33342/PI double-staining. Protein expression was determined by western blot analysis.

Results
The main ingredients of the herb, including curzerene (26.45%), eucalyptol (12.04%), curcumol (9.04%), pyridine (7.97%), germacrone (7.89%), β-elemene (7.36%), τ-elemene (4.11%) and 28 other ingredients, including curdione, were consistent with the chemical profiles of zedoary. Zedoary oil significantly decreased the cell viability of AGS cells (P < 0.01) and MGC 803 cells (P < 0.01), and the inhibitory effects were attenuated by elevated concentrations of FBS. At high concentrations (≥90 μg/mL), zedoary oil killed GES-1 cells. At low concentrations (≤60 μg/mL), zedoary oil was less inhibitory toward normal gastric epithelial cells than gastric cancer cell lines. In AGS cells, zedoary oil inhibited cell proliferation in a dose- and time-dependent manner, with decreased PCNA protein expression in the zedoary oil-treated cells, and arrested the cell cycle at S, G2/M and G0/G1 stages after treatment for 6–48 h. At concentrations of 30, 60 and 90 μg/mL, which resulted in significant inhibition of proliferation and cell cycle arrest, zedoary oil induced cell apoptosis. In addition, Hoechst 33342/PI double-staining confirmed the morphological characteristics of cell apoptosis at 24 h. Zedoary oil upregulated the ratio of Bax/Bcl-2 protein expression (P < 0.01).

Conclusions
Zedoary oil inhibited AGS cell proliferation through cell cycle arrest and cell apoptosis promotion, which were related to Bax/Bcl-2 protein expression.
The current practice trends in pediatric bone-anchored hearing aids in Canada: A national clinical and surgical practice survey
Authors: Liu C Carrie , Chadha Neil K , Bance Manohar , Hong Paul 
Published: July 2013

Background Since the introduction of bone-anchored hearing aids (BAHAs) in the 1980s, the practices of surgeons who implant these hearing aids have become varied; different indications and surgical techniques are utilized depending on the surgeon and institution. The objective of the current study is to describe the clinical and surgical practices of otolaryngologists in Canada who perform pediatric BAHA operations. Methods A detailed practice questionnaire was devised and sent to all members of the Canadian Society of Otolaryngology-Head and Neck Surgery. Those who performed pediatric BAHA surgeries were asked to participate. Results Twelve responses were received (response rate of 80%). All of the respondents identified congenital aural atresia to be an indication for pediatric BAHAs. Other indications were chronic otitis externa or media with hearing loss (92%), allergic reactions to conventional hearing aids (75%), congenital fixation or anomaly of ossicular chain (67%), and unilateral deafness (25%). Minor complications, such as skin reactions, were reported in 25% of cases, while major complications were very rare. There was great variability with regards to surgical techinque and post-operative management. The extent of financial support for the BAHA hardware and device also varied between provinces, and even within the same province. Conclusion There is a lack of general consensus regarding pediatric BAHA surgeries in Canada. With such a small community of otolaryngologists performing this procedure, we are hopeful that this survey can serve as an impetus for a national collaboration to establish a set of general management principles and inspire multi-site research ventures.
Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis
Authors: Tricco Andrea C , Soobiah Charlene , Antony Jesmin , Hemmelgarn Brenda , Moher David , Hutton Brian , Straus Sharon E 
Published: June 2013

AbstractBackgroundPatients undergoing surgery or chemotherapy often experience nausea and vomiting. To increase their quality of life and treatment satisfaction, antiemetic medication, such as serotonin receptor antagonists, is often prescribed for patients experiencing these symptoms. However, early warning signs suggest that serotonin receptor antagonists can cause harm, including arrhythmia. Our objective is to identify the most effective interventions that mitigate the risk of adverse cardiac events associated with serotonin receptor antagonists in patients undergoing surgery and chemotherapy through a systematic review and network meta-analysis.Methods/designWe will search electronic databases (for example, MEDLINE, Embase) from inception onwards, as well as dissertations and governmental reports, to identify interventions (for example, telemetry, electrocardiography, electrolyte monitoring) that decrease the cardiac risk associated with serotonin receptor antagonists among surgery and chemotherapy patients. Eligible comparators include placebo or supportive care; eligible study designs are experimental studies (randomized controlled trials (RCTs), quasi-RCTs, non-RCTs), non-experimental studies (interrupted time series, controlled before-and-after studies), and cohort studies. Outcomes of interest include arrhythmia, sudden cardiac death, QT prolongation, PR prolongation, and all-cause mortality. We will include unpublished studies and studies published in languages other than English.Draft inclusion and exclusion criteria will be established and pilot tested amongst the team. Subsequently, two team members will screen the results in duplicate and resolve conflicts through discussion. The same process will be followed to screen full-text articles, data abstraction, and appraise quality or risk of bias. To determine validity of results, experimental and quasi-experimental studies will be assessed using the Cochrane Effective Practice and Organisation of Care (EPOC) Risk of Bias tool, while cohort studies will be appraised using the Newcastle-Ottawa Scale. We anticipate sufficient data and homogeneity to conduct random effects meta-analysis and network or mixed treatment comparisons meta-analysis, if appropriate.DiscussionOur results will provide information regarding the utility of different strategies that can be used to mitigate cardiac risk amongst patients taking serotonin antagonist receptors. Such results are likely to be of use to clinicians prescribing these agents, as well as policy makers responsible for making decisions about antiemetic medications.Systematic review registrationPROSPERO registry number:CRD42013003565
Health impact assessment of air pollution in Shiraz, Iran: a two-part study
Authors: Gharehchahi Ehsan , Mahvi Amir Hossein , Amini Hassan , Nabizadeh Ramin , Akhlaghi Ali Asghar , Shamsipour Mansour , Yunesian Masud 
Published: June 2013

Abstract
We aimed to assess health-impacts of short-term exposure to the air pollutants including PM10, SO2, and NO2 in Shiraz, Iran in a two-part study from 2008 to 2010. In part I, local relative risks (RRs) and baseline incidences (BIs) were calculate using generalized additive models. In part II, we estimated the number of excess hospitalizations (NEHs) due to cardiovascular diseases (CDs), respiratory diseases (RDs), respiratory diseases in elderly group (RDsE—people older than 65 years old), and chronic obstructive pulmonary diseases (COPDs) as a result of exposure to air pollutants using AirQ model, which is proposed approach for air pollution health impact assessment by World Health Organization. In part I, exposure to increase in daily mean concentration of PM10 was associated with hospitalizations due to RDs with a RR of 1.0049 [95% confidence interval (CI), 1.0004 to 1.0110]. In addition, exposure to increase in daily mean concentration of SO2 and NO2 were associated with hospitalizations due to RDsE and COPDs with RRs of 1.0540 [95% CI, 1.0050 to 1.1200], 1.0950 [95% CI, 1.0700 to 1.1100], 1.0280 [95% CI, 1.0110 to 1.0450] and 1.0360 [95% CI, 1.0210 to 1.0510] per 10 μg/m3 rise of these pollutants, respectively. In part II, the maximum NEHs due to CDs because of exposure to PM10 were in 2009—1489 excess cases (ECs). The maximum NEHs due to RDs because of exposure to PM10 were in 2009—1163 ECs. Meanwhile, the maximum NEHs due to RDsE and COPDs because of exposure to SO2 were in 2008, which are 520 and 900 ECs, respectively. In conclusion, elevated morbidity risks were found from acute exposure to air pollutants.
Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism
Authors: Nguyen-Vu Trang , Vedin Lise-Lotte , Liu Ka , Jonsson Philip , Lin Jean Z , Candelaria Nicholes R , Candelaria Lindsay P , Addanki Sridevi , Williams Cecilia , Gustafsson Jan-Åke , Steffensen Knut R , Lin Chin-Yo 
Published: June 2013

Abstract
Introduction
Liver × receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors and have established functions as regulators of cholesterol, glucose, and fatty acid metabolism and inflammatory responses. Published reports of anti-proliferative effects of synthetic LXR ligands on breast, prostate, ovarian, lung, skin, and colorectal cancer cells suggest that LXRs are potential targets in cancer prevention and treatment.

Methods
To further determine the effects of LXR ligands and identify their potential mechanisms of action in breast cancer cells, we carried out microarray analysis of gene expression in four breast cancer cell lines following treatments with the synthetic LXR ligand GW3965. Differentially expressed genes were further subjected to gene ontology and pathway analyses, and their expression profiles and associations with disease parameters and outcomes were examined in clinical samples. Response of E2F target genes were validated by real-time PCR, and the posited role of E2F2 in breast cancer cell proliferation was tested by RNA interference experiments.

Results
We observed cell line-specific transcriptional responses as well as a set of common responsive genes. In the common responsive gene set, upregulated genes tend to function in the known metabolic effects of LXR ligands and LXRs whereas the downregulated genes mostly include those which function in cell cycle regulation, DNA replication, and other cell proliferation-related processes. Transcription factor binding site analysis of the downregulated genes revealed an enrichment of E2F binding site sequence motifs. Correspondingly, E2F2 transcript levels are downregulated following LXR ligand treatment. Knockdown of E2F2 expression, similar to LXR ligand treatment, resulted in a significant disruption of estrogen receptor positive breast cancer cell proliferation. Ligand treatment also decreased E2F2 binding to cis-regulatory regions of target genes. Hierarchical clustering of breast cancer patients based on the expression profiles of the commonly downregulated LXR ligand-responsive genes showed a strong association of these genes with patient survival.

Conclusions
Taken together, these results indicate that LXR ligands target gene networks, including those regulated by E2F family members, are critical for tumor biology and disease progression and merit further consideration as potential agents in the prevention and treatment of breast cancers.
Organisational processes around the investigation of serious events
Authors: Cohen Mark 
Published: July 2013

SummaryThis editorial focuses on a psychosocial application of psychoanalytic thinking to the processes which are in place to investigate serious events in psychiatric healthcare. It argues that the structures and processes in place can be understood with reference to organisational defences and to the ‘actor–network theory’. A common reason for such an investigation is a completed suicide. It is suggested that defensive processes may occur in response to the anxieties associated with serious events such as suicide and are of concern in terms of psychiatric care retaining a capacity for emotionally involved practice.
Solid-state 93Nb NMR Study of Nitrogen-doped Lamellar Niobic Acid
Authors: Yamada Kazuhiko , Shimizu Tadashi , Nakai Toshihito , Deguchi Kenzo , Yue Bing , Ye Jinhua 
Published: June 2013

Abstract
We present the structural investigation of a visible-light nitrogen-doped photocatalyst, nitrogen-doped HNb3O8, which was performed by the solid-state 93Nb nuclear magnetic resonance (NMR) methodology.
Dydaktyka przekładu audiowizualnego na filologii romańskiej od podstaw: metody, treści, propozycje rozwiązań
Authors: Kaczmarek Anna 
Published: July 2013

Teaching audio‑visual translation at the “French Philology level 0” course: methods, contents, clues
In the face of a sensible diminution of the number of high‑school graduates able to communicate in French well enough to follow the “classical” French Philology course, many Polish universities offer their students the possibility of studying “French Philology level 0”. One of the key skills developed by this course is translation, including basic audio‑visual translation competences. The paper shows some examples of translator training clues that have been worked out at the Opole University.
Thinking like a wetland
Authors: Dillon Patrick , Gross Philip , Irvine Richard , Price Valerie Coffin , Staddon Chad 
Published: June 2013

Abstract
This article is an invitation to therapeutic deconstruction: a call to reconsider our assumptions about land, water and the relationship between the wet and the dry. It takes the form of a dialogue in which poetry (Gross) and visual art (Price) prompts, probes and challenges reflections offered by a natural resource economist (Staddon), a cultural ecologist (Dillon) and an anthropologist (Irvine). From our multiple perspectives, we explore the wetland as a site of common interest, and through different approaches to the thought experiment of what it might mean to ‘think like a wetland’ we seek to engage with the materiality of these places. We ask what it means to be a part of a wetland, not simply treating these habitats as resources to be managed, but as sites of dwelling that have agency in their own right.
Flood memories – media, narratives and remembrance of wet landscapes in England
Authors: Krause Franz , Garde-Hansen Joanne , Whyte Nicola 
Published: June 2013

Abstract
Floods are a threat to livelihoods and landscapes in many places around the world and at many points in history. Yet, they also seem to be an intrinsic component of many landscapes and livelihoods. This article explores the interconnection of multi-directional narratives of flooding through the representation of the memories of inhabitants of wet landscapes in past and present England. The article will illustrate three aspects of the relationship between floods and memory: first, the contextual mediation of flood memories in the contemporary moment. Here audio-visual and textual media (photographs, newspapers articles, television news broadcasts) of present and past flooding compete for our attention; second, the documentation of the early modern English treatment of a changing ‘wateryscape’ and whether we can discern dis/continua with and in contemporary media; and third, the dis/connecting narratives of living with floods in the present day. We emphasize that remembering and forgetting floods is an active and creative process for both flooding communities and those who research them. Stories and experiences of past floods are strategically used within, between and across communities to construct a particular sense of self and a statement on vulnerability and resilience to floods. Thereby the article contributes to developing a creative engagement between past and present, which goes beyond encompassing hegemonic narratives of historical and environmental change by reinforcing the potential of researching everyday, experiential landscapes beyond arbitrary periodization.
Archiving memories of changing flood risk: Interdisciplinary explorations around knowledge for resilience
Authors: McEwen Lindsey , Reeves Dave , Brice Jethro , Meadley Fiona Kam , Lewis Karen , Macdonald Neil 
Published: June 2013

Abstract
This article explores the changing nature of the flood archive, drawing on different disciplinary perspectives, approaches and attitudes. It uses a braiding metaphor to map a journey around shifting islands that contain different primary research on flood archives – in expert hydrology, in lay flood knowledges, in capturing flood narratives and memories, in drawing on folk song as an informal archive and in charting archives for a fluid landscape. The narrative and critical commentary ‘in the flow’ draws out interlinking themes, exploring what forms of archive can capture, and share reflections on, a landscape that is increasingly or episodically wet – a fluid landscape? It explores different facets of the flood archive: in terms of fact versus fiction, the changing nature of material archived, who archives, changing archival practice, changing use of archives and future archives. It concludes that informal archives have the potential to form a key resource in communities learning to live with changing flood risk and uncertainty.
Halphen's transform and middle convolution
Authors: Reiter Stefan 
Published: June 2013

Abstract

We show that the Halphen transform of a Lamé equation can be written as the symmetric square of the Lamé equation followed by an Euler transform.
We use this to compute a list of Lamé equations with arithmetic Fuchsian monodromy group. It contains all those Lamé equations
where the quaternion algebra A associated
to the arithmetic Fuchsian group is defined over ℚ.
Multilingual Speaker Identification by Combining Evidence from LPR and Multitaper MFCC
Authors: Nagaraja B.G. , Jayanna H.S. 
Published: June 2013

AbstractIn this work, the significance of combining the evidence from multitaper mel-frequency cepstral coefficients (MFCC), linear prediction residual (LPR), and linear prediction residual phase (LPRP) features for multilingual speaker identification with the constraint of limited data condition is demonstrated. The LPR is derived from linear prediction analysis, and LPRP is obtained by dividing the LPR using its Hilbert envelope. The sine-weighted cepstrum estimators (SWCE) with six tapers are considered for multitaper MFCC feature extraction. The Gaussian mixture model–universal background model is used for modeling each speaker for different evidence. The evidence is then combined at scoring level to improve the performance. The monolingual, crosslingual, and multilingual speaker identification studies were conducted using 30 randomly selected speakers from the IITG multivariability speaker recognition database. The experimental results show that the combined evidence improves the performance by nearly 8–10% compared with individual evidence.
Far-field disentanglement of modes in hybrid plasmonic-photonic crystals by fluorescence nano-reporters
Authors: Ungureanu Simona , Kolaric Branko , Chen Jianing , Hillenbrand Rainer , Vallée Renaud A. L. 
Published: June 2013

AbstractIn this paper, the resonance modes exhibited by a hybrid nanostructure have been disentangled in the far-field owing to narrow-band fluorescence nano-reporters. Hybrid plasmonic-photonic crystals were fabricated using large (457 nm) monodisperse polystyrene spheres self-assembled into 2D photonic crystals and subsequently coated by a 30 nm thick silver layer. Such structures exhibit a complex resonance pattern, which has been elucidated owing to numerical simulations and electric near-field patterns obtained with a scattering type scanning near-field optical microscope (s-SNOM). For the sake of disentangling the resonance modes of the hybrid structure in the far-field, different types of semiconductor quantum dots (QDs), acting as nano-reporters of the local interactions, were dispersed on top of distinct structures. Depending on the relative overlap of the emission spectrum of a particular type of QDs with the resonance features of the hybrid structure, we affect their emission rate in a unique way, as a consequence of the complex interaction occurring between the plasmo-photonic modes and the excitons. Such plasmonic structures appear to be particularly relevant for fluorescence-based sensing devices.
Great minds think alike. Experimental study on lexical alignment in human-agent interaction
Authors: Rosenthal-von der Pütten Astrid M. , Wiering Leonard , Krämer Nicole 
Published: June 2013

Abstract
Based on first results on lexical alignment towards computers demonstrating that human users adapt their word choice to that of a computer, it was tested whether participants will also adapt to a virtual agent within a tutoring setting. In an experimental between subjects design (N = 40) participants were presented with information on three medical topics by a virtual agent either using lay language or technical terms. Results show that participants aligned to the word choice of the agent in both conditions, while there were no effects for perceived competence and likeability.
Multistatus Interaktionsgeräte für interaktive Tische
Authors: Kunz Andreas , Fjelds Morten , Alavi Ali 
Published: June 2013

Zusammenfassung
In diesem Beitrag werden ein Verfahren und ein Prototyp vorgestellt, die es ermöglichen, viele Interaktionsgeräte gleichzeitig auf einer interaktiven Tischfläche zu betreiben, ohne dass die Reaktionszeit des Systems hierdurch reduziert wird. Darüber hinaus können die Interaktionsgeräte aktiv ihren Zustand über ein mehrstelliges Bitwort an das System signalisieren. Dies erlaubt eine zusätzliche, hochauflösende Eingabe von Information.
Crystal structure of catena-bis(µ3-5-methoxyisophthalato)-bis(µ2-1,6- bis(imidazol-1-yl)-hexane)nickel(II), [Ni2(CH3OC8H3O4)2(C12H18N4)2], C42H48N8Ni2O10
Authors: Hong Dong-Feng , Han Min-Le 
Published: June 2013

Abstract C42H48N8Ni2O10, triclinic, P1̅ (no. 2), a = 8.326(2) Å, b = 10.128(2) Å, c = 25.109(4) Å, α = 97.935(2)°, β = 97.815(2)°, γ = 99.716(2)°, V = 2039.1 Å3, Z = 2, Rgt(F) = 0.0496, wRref(F2) = 0.1443, T = 296 K.
Crystal structure of (E)-5-ethoxy-4-(4-oxo-1-phenylpent-1-en-2-yl)furan- 3-(2H)-one, C17H18O4
Authors: Wang Qiang , Ma Shuqi , Feng Lin 
Published: June 2013

Abstract C17H18O4, monoclinic, P21/c (no. 14), a = 9.437(2) Å, b = 17.895(4) Å, c = 8.661(2) Å, β = 91.58(3)°, V = 1462.1 Å3, Z = 4, Rgt(F) = 0.0531, wRref(F2) = 0.1336, T = 293 K.
Crystal structure of 4,4'-bipyridine–chloroacetic acid (1:2), C10H8N2 · 2 C2H3ClO2, C14H14Cl2N2O4
Authors: Qi Ying-Yu , Zhang Shu-Xia 
Published: June 2013

Abstract C14H14Cl2N2O4, monoclinic, P21/c (no. 14), a = 9.339(5) Å, b = 4.237(2) Å, c = 20.02(1) Å, β = 90.326(8)°, V = 792.0 Å3, Z = 2, Rgt(F) = 0.0588, wRref(F2) = 0.1776, T = 296 K.
Crystal Structure Of Cadmium Iridium, Cd41Ir8
Authors: Feng Xian-Juan , Xiong Ding-Bang , Prots Yurii , Schnelle Walter , Zhao Jing-Tai , Grin Yuri 
Published: June 2013

Abstract Cd41Ir8, trigonal, R3̅ (no. 148), a = 14.8489(6) Å, c = 15.980(1) Å, V = 3051.4(4) Å3, Z = 3, Rgt(F) = 0.037, wRref(F2) = 0.067, T = 293 K.
Crystal structure of orthorhombic-catena-((µ5-adipato-κ4O,O':O,O')-lead(II)), C6H8O4Pb
Authors: Zhao Dan , Liang Peng , Li Yan-Pin , Liu Qian-Qian , Li Wen-Long 
Published: June 2013

Abstract C6H8O4Pb, orthorhombic, Pnma (no. 62), a = 21.927(2) Å, b = 7.2139(7) Å, c = 4.7357(5) Å, V = 749.1 Å3, Z = 4, Rgt(F) = 0.0429, wRref(F2) = 0.1149, T = 296 K.