bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in anorexia nervosa, bulimia nervosa and eating disorder not-otherwise-specified
Authors: DeJong Hannah , Oldershaw Anna , Sternheim Lot , Samarawickrema Nelum , Kenyon Martha D , Broadbent Hannah , Lavender Anna , Startup Helen , Treasure Janet , Schmidt Ulrike 
Published: November 2013

AbstractBackgroundThis study aimed to assess differences in Quality of Life (QoL) across eating disorder (ED) diagnoses, and to examine the relationship of QoL to specific clinical features.Results199 patients with a diagnosed ED completed the Clinical Impairment Assessment (CIA) [Cognitive Behavior Therapy and Eating Disorders, 315–318, 2008] and the Eating Disorders Examination (EDE) [Int J Eat Disord6:1–8]. Differences between diagnostic groups were examined, as were differences between restrictive and binge-purge subtypes.CIA scores and EDE scores were positively correlated and higher in groups with binge-purge behaviours. CIA scores were not correlated with BMI, illness duration or frequency of bingeing/purging behaviours, except in the binge-purge AN group, where CIA scores negatively correlated with BMI.ConclusionsPatients with EDs have poor QoL and impairment increases with illness severity. Patients with binge/purge diagnoses are particularly impaired. It remains unclear which clinical features best predict the degree of impairment experienced by patients with EDs.
A case of Strongyloides hyperinfection associated with tuberculosis
Authors: Iwashita Yoshiaki , Suzuki Kei , Masui Asami , Kawamoto Eiji , Yokoyama Kazuto , Yamamoto Akitaka , Omori Yukinari , Ishikura Ken , Hatada Tsuyoshi , Fujioka Masaki , Takeda Taichi , Imai Hiroshi 
Published: November 2013

Abstract
Strongyloidiasis is a parasitic infection that occurs in tropical regions. Hyperinfection, which is an accelerated autoinfection, is often associated with an immunosuppressive state, such as HTLV-1 infection or steroid use. Immunosuppression can also lead to reactivation of tuberculosis infection. These infections may have interacted as a result of impaired cellular immunity. A 28-year-old Nepali male was referred to our hospital for slight abdominal pain and high fever. An abdominal CT scan showed ascites and intestinal swelling. He was admitted with suspected gastroenteritis. Results of stool microscopy on the third day of hospitalization revealed abundant strongylid larvae. We diagnosed a Strongyloides hyperinfection and prescribed ivermectin. Although the numbers of strongylid organisms in the patient’s stool soon diminished, his temperature remained high. After receiving a second dose of ivermectin on day 17, he was transferred to a nearby hospital for observation, where he was noted to have massive pleural effusion. He returned to our hospital where his pleural effusion was found to be positive for adenosine deaminase (ADA), and he was diagnosed with a tuberculosis infection. Strongyloides hyperinfection can occur in a non-endemic region. It can be associated with tuberculosis infection possibly due to impaired cellular immunity. It is important to consider other possible infections when treating a patient with an infection associated with impaired cellular immunity.
A novel risk-based analysis for the production system under epistemic uncertainty
Authors: Khalaj Mehran , Khalaj Fereshteh , Khalaj Amineh 
Published: November 2013

Abstract
Risk analysis of production system, while the actual and appropriate data is not available, will cause wrong system parameters prediction and wrong decision making. In uncertainty condition, there are no appropriate measures for decision making. In epistemic uncertainty, we are confronted by the lack of data. Therefore, in calculating the system risk, we encounter vagueness that we have to use more methods that are efficient in decision making. In this research, using Dempster-Shafer method and risk assessment diagram, the researchers have achieved a better method of calculating tools failure risk. Traditional statistical methods for recognizing and evaluating systems are not always appropriate, especially when enough data is not available. The goal of this research was to present a more modern and applied method in real world organizations. The findings of this research were used in a case study, and an appropriate framework and constraint for tools risk were provided. The research has presented a hopeful concept for the calculation of production systems' risk, and its results show that in uncertainty condition or in case of the lack of knowledge, the selection of an appropriate method will facilitate the decision-making process.
The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer’s disease
Authors: Shah Raj C , Kamphuis Patrick J , Leurgans Sue , Swinkels Sophie H , Sadowsky Carl H , Bongers Anke , Rappaport Stephen A , Quinn Joseph F , Wieggers Rico L , Scheltens Philip , Bennett David A 
Published: November 2013

Abstract
Introduction
Souvenaid® containing Fortasyn® Connect is a medical food designed to support synapse synthesis in persons with Alzheimer’s disease (AD). Fortasyn Connect includes precursors (uridine monophosphate; choline; phospholipids; eicosapentaenoic acid; docosahexaenoic acid) and cofactors (vitamins E, C, B12, and B6; folic acid; selenium) for the formation of neuronal membranes. Whether Souvenaid slows cognitive decline in treated persons with mild-to-moderate AD has not been addressed.

Methods
In a 24-week, double-masked clinical trial at 48 clinical centers, 527 participants taking AD medications [52% women, mean age 76.7 years (Standard Deviation, SD = 8.2), and mean Mini-Mental State Examination score 19.5 (SD = 3.1, range 14–24)] were randomized 1:1 to daily, 125-mL (125 kcal), oral intake of the active product (Souvenaid) or an iso-caloric control. The primary outcome of cognition was assessed by the 11-item Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-cog). Compliance was calculated from daily diary recordings of product intake. Statistical analyses were performed using mixed models for repeated measures.

Results
Cognitive performance as assessed by ADAS-cog showed decline over time in both control and active study groups, with no significant difference between study groups (difference =0.37 points, Standard Error, SE = 0.57, p = 0.513). No group differences in adverse event rates were found and no clinically relevant differences in blood safety parameters were noted. Overall compliance was high (94.1% [active] and 94.5% [control]), which was confirmed by significant changes in blood (nutritional) biomarkers.

Conclusions
Add-on intake of Souvenaid during 24 weeks did not slow cognitive decline in persons treated for mild-to-moderate AD. Souvenaid was well tolerated in combination with standard care AD medications.

Trial registration
Dutch Trial Register number: NTR1683.
Preoperative Magnetic Resonance Imaging Assessment of Circumferential Resection Margin Predicts Disease-Free Survival and Local Recurrence: 5-Year Follow-Up Results of the MERCURY Study
Authors: Taylor Fiona G.M. , Quirke Philip , Heald Richard J. , Moran Brendan J. , Blomqvist Lennart , Swift Ian R. , Sebag-Montefiore David , Tekkis Paris , Brown Gina 
Published: November 2013

Purpose The prognostic relevance of preoperative high-resolution magnetic resonance imaging (MRI) assessment of circumferential resection margin (CRM) involvement is unknown. This follow-up study of 374 patients with rectal cancer reports the relationship between preoperative MRI assessment of CRM staging, American Joint Committee on Cancer (AJCC) TNM stage, and clinical variables with overall survival (OS), disease-free survival (DFS), and time to local recurrence (LR). Patients and Methods Patients underwent protocol high-resolution pelvic MRI. Tumor distance to the mesorectal fascia of ≤ 1 mm was recorded as an MRI-involved CRM. A Cox proportional hazards model was used in multivariate analysis to determine the relationship of MRI assessment of CRM to survivorship after adjusting for preoperative covariates. Results Surviving patients were followed for a median of 62 months. The 5-year OS was 62.2% in patients with MRI-clear CRM compared with 42.2% in patients with MRI-involved CRM with a hazard ratio (HR) of 1.97 (95% CI, 1.27 to 3.04; P < .01). The 5-year DFS was 67.2% (95% CI, 61.4% to 73%) for MRI-clear CRM compared with 47.3% (95% CI, 33.7% to 60.9%) for MRI-involved CRM with an HR of 1.65 (95% CI, 1.01 to 2.69; P < .05). Local recurrence HR for MRI-involved CRM was 3.50 (95% CI, 1.53 to 8.00; P < .05). MRI-involved CRM was the only preoperative staging parameter that remained significant for OS, DFS, and LR on multivariate analysis. Conclusion High-resolution MRI preoperative assessment of CRM status is superior to AJCC TNM–based criteria for assessing risk of LR, DFS, and OS. Furthermore, MRI CRM involvement is significantly associated with distant metastatic disease; therefore, colorectal cancer teams could intensify treatment and follow-up accordingly to improve survival outcomes.
Can Montana Participate in the Lumber Export Market to China?
Authors: Scudder Micah , Venn Tyron , Morgan Todd A 
Published: November 2013

Abstract
The severe recession and the housing and lumber market collapse in the 2007 to 2011 period has led to increased interest in market diversification in an attempt to cushion the impact of market swings in the United States. An international market diversification strategy has been implemented by several lumber manufacturers in Oregon and Washington that allowed them to be well positioned to shift sales to the Asian market during this domestic lumber market collapse. By diversifying a portion of sales into new international markets, Montana sawmills may be able to stabilize demand for their products instead of being subject to domestic market demand swings. To determine if Montana sawmills can participate in the Chinese export market and to identify the best export opportunities, a strategic assessment was conducted through the use of a SWOT (strengths, weaknesses, opportunities, threats) analysis. For this process, Montana's lumber industry core competencies were identified and aligned with Chinese wood product demand to highlight potential export opportunities for the Montana sawmill industry. It was found that the optimal export opportunity consisted of dimension lumber from Douglas-fir (Pseudotsuga menziesii), lodgepole pine (Pinus contorta), and ponderosa pine (Pinus ponderosa) species with nominal 2 by 4 dimensions and with No. 3 utility and No. 4 economy product grades. This product mix provided the best fit with Montana's timber supply, manufacturing capabilities, and Chinese product demand. By incorporating this strategy with the help of international lumber brokers and experienced exporters, Montana sawmills will be well positioned to respond to domestic market fluctuations and future Chinese product demand opportunities.
A Review of Partnership Studies in the Forest Products Value Chain: With a Focus on Developed Countries (United States, Canada, and Western Europe)
Authors: Piltan Mehdi , Sowlati Taraneh 
Published: November 2013

Abstract
The forest products sector in developing countries has been losing its competitiveness due to the fast rate of change in technologies and globalization. Partnership with other companies within and outside the sector could help as a strategy to remain competitive. However, partnership is costly and has a high failure rate. Therefore, partner selection and partnership evaluation are important. This article summarizes the success factors in partnerships based on the literature and reviews the previous studies on partnership in the forest industry. Previous studies in the forest products sector have identified the potential opportunities and attributes of partnerships in different business functions, such as in marketing, procurement, and transportation. Nonetheless, the objectives of entering into partnerships and the factors contributing to successful partnerships in the forest products industry have not been investigated yet. Moreover, to our knowledge, no study has focused on the selection of partners and evaluation of partnerships in forest products value chains using analytical frameworks.
State of the Art for Measurement of Urine Albumin: Comparison of Routine Measurement Procedures to Isotope Dilution Tandem Mass Spectrometry
Authors: Bachmann Lorin M , Nilsson Goran , Bruns David E , McQueen Matthew J , Lieske John C , Zakowski Jack J , Miller W Greg 
Published: November 2013

Abstract

BACKGROUND
Urine albumin is the primary biomarker for detection and monitoring of kidney damage. Because fixed decision criteria are used to identify patients with increased values, we investigated if commonly used routine measurement procedures gave comparable results.

METHODS
Results from 17 commercially available urine albumin measurement procedures were investigated vs an isotope dilution mass spectrometry (IDMS) procedure. Nonfrozen aliquots of freshly collected urine from 332 patients with chronic kidney disease, diabetes, cardiovascular disease, and hypertension were distributed to manufacturers to perform urine albumin measurements according to the respective instructions for use for each procedure. Frozen aliquots were used for measurements by the IDMS procedure. An error model was used to determine imprecision and bias components.

RESULTS
Median differences between the largest positive and negative biases vs IDMS were 45%, 37%, and 42% in the concentration intervals of 12–30 mg/L, 31–200 mg/L, and 201–1064 mg/L, respectively. Biases varied with concentration for most procedures and exceeded ±10% over the concentration interval for 14 of 16 quantitative procedures. Mean biases ranged from −35% to 34% at 15 mg/L. Dilution of samples with high concentrations introduced bias for 4 procedures. The combined CV was &gt;10% for 5 procedures. It was not possible to estimate total error due to dependence of bias on concentration. CVs for sample-specific influences were 0% to 15.2%.

CONCLUSIONS
Bias was the dominant source of disagreement among routine measurement procedures. Consequently, standardization efforts will improve agreement among results. Variation of bias with concentration needs to be addressed by manufacturers.
Fundamental biological importance of solvated electrons in humans
Authors: Getoff Nikola 
Published: November 2013

Abstract
In recent years, “solvated electrons” were shown to be emitted by various biological systems in humans such as hormones, enzymes, amino acids, etc., even by vitamins, dyes, and other organic compounds. Based on experimental results and data from the literature, it is hypothesized that most biological systems in humans are capable of emission. Most systems in humans generate as well as consume and transfer them to other moieties, hence enabling intersystem communication via the brain. Emission of is associated with generation of free radicals, which are likewise involved in biological processes in humans. The data presented in this article underline this hypothesis, which offers a completely new concept in the course of biological mechanisms in humans.
Neuropeptides and skin aging
Authors: Elewa Rana , Makrantonaki Evgenia , Zouboulis Christos C. 
Published: November 2013

Abstract
Neuropeptides (NP) are peptides that are released as chemical messengers from nerve cells. They act either in an endocrine manner, where they reach their target cells via the bloodstream or a paracrine manner, as co-transmitters modulating the function of neurotransmitters. To date approximately 100 different NP have been described in the literature. In recent years, several studies have documented that human skin expresses several functional receptors for NP, such as corticotropin-releasing hormone, melanocortins, β-endorphin, vasoactive intestinal polypeptide, neuropeptide Y and calcitonin gene-related peptide. These receptors modulate the production of inflammatory cytokines, proliferation, differentiation, lipogenesis and hormone metabolism in human skin cells. In addition, several NP are directly produced by human skin cells, indicating the complexity of understanding the real functions of NPs in human skin. In this review we address the possible effects of neuropeptides on the pathogenesis of aged skin.
A Fourier truncated regularization method for a Cauchy problem of a semi-linear elliptic equation
Authors: Zhang Hongwu , Wei Ting 
Published: November 2013

Abstract.
In this paper, a Cauchy problem for a semi-linear elliptic equation is considered. This problem is well known to be severely ill-posed and regularization methods are required. We use a Fourier truncated regularization method to deal with it, and a convergence estimate for the regularized solution is obtained under an a-priori bound assumption for the exact solution. Some numerical results are given to show the effectiveness of truncated method.
The Use of Numerical Extrapolation to Accelerate Delayed Ettringite Formation Tests
Authors: Robertson J. Bret , Ley M. Tyler 
Published: November 2013

Abstract
Current test methods for evaluating the potential for delayed ettringite formation (DEF) are quite time consuming. It is common for these tests to take over one year to complete due to the fact that there are no minimum expansion criteria at a prescribed number of days. A novel numerical extrapolation technique is presented that can predict the final expansion of the specimen after expansion starts. The accuracy of the method is shown for 30 tests from laboratory and field concrete with expansion from DEF. The technique was able to accurately predict the ultimate expansion within 0.18 % and shorten the test by over 80 %. This time savings would be especially useful for owners who need to evaluate the potential for DEF expansion for an existing structure.
Vanishing large ovarian cyst with thyroxine therapy
Authors: Dharmshaktu Pramila , Kutiyal Aditya , Dhanwal Dinesh 
Published: November 2013

Summary
A 21-year-old female patient recently diagnosed with severe hypothyroidism was found to have a large ovarian cyst. In view of the large ovarian cyst, she was advised to undergo elective laparotomy in the gynaecology department. She was further evaluated in our medical out-patient department (OPD), and elective surgery was withheld. She was started on thyroxine replacement therapy, and within a period of 4 months, the size of the cyst regressed significantly, thereby improving the condition of the patient significantly. This case report highlights the rare and often missed association between hypothyroidism and ovarian cysts. Although very rare, profound hypothyroidism that can cause ovarian cysts in an adult should always be kept in the differential diagnosis to avoid unnecessary ovarian surgery.

Learning points

Hypothyroidism should be considered in the differential diagnosis of adult females presenting with multicystic ovarian tumours.

Adequate thyroid hormone replacement therapy can prevent these patients from undergoing unnecessary and catastrophic ovarian resection.

Surgical excision should be considered only when adequate thyroid replacement therapy fails to resolve ovarian enlargement.

In younger women with ovarian cysts, it is also desirable to avoid unnecessary surgery so as to not compromise fertility in the future.
Adiposity and Different Types of Screen Time
Authors: Falbe Jennifer , Rosner Bernard , Willett Walter C. , Sonneville Kendrin R. , Hu Frank B. , Field Alison E. 
Published: November 2013

OBJECTIVE:
Few prospective studies have examined separate forms of screen time in relation to adiposity. Our objective was to assess independent relations of television, electronic games (video/computer), and digital versatile disc (DVD)/videos and total screen time with change in adolescent BMI.

METHODS:
Using data from the 2004, 2006, and 2008 waves of the ongoing Growing up Today Study II, we assessed baseline and 2-year change in reported screen time in relation to concurrent change in BMI among 4287 girls and 3505 boys aged 9 to 16 years in 2004. Gender-specific models adjusted for previous BMI, age, race/ethnicity, growth/development, months between questionnaires, and physical activity.

RESULTS:
Among girls and boys, each hour per day increase in reported television viewing was associated with a 0.09 increase in BMI (Ps &lt; .001), and each hour per day increase in total screen time was associated with a 0.07 increase among girls and 0.05 increase among boys (Ps &lt; .001). Among girls only, greater baseline television, games, and total screen time and change in DVDs/videos were associated with gains in BMI (Ps &lt; .05). BMI gains associated with change in television and total screen time were stronger among overweight girls than lean girls (Ps-heterogeneity &lt; .001).

CONCLUSIONS:
Television, which remains the steadiest source of food advertising, was most consistently associated with BMI gains. Among girls, electronic games and DVDs/videos were also related to increased BMI, possibly due to influences of product placements and advergames on diet and/or distracted eating. Adolescents, especially overweight adolescents, may benefit from reduced time with multiple types of media.
National, Regional, and State Abusive Head Trauma: Application of the CDC Algorithm
Authors: Shanahan Meghan E. , Zolotor Adam J. , Parrish Jared W. , Barr Ronald G. , Runyan Desmond K. 
Published: November 2013

OBJECTIVE:
To examine national, regional, and state abusive head trauma (AHT) trends using child hospital discharge data by applying a new coding algorithm developed by the Centers for Disease Control and Prevention (CDC).

METHODS:
Data from 4 waves of the Kids’ Inpatient Database and annual discharge data from North Carolina were used to determine trends in AHT incidence among children &lt;1 year of age between 2000 and 2009. National, regional, and state incidence rates were calculated. Poisson regression analyses were used to examine national, regional, and state AHT trends.

RESULTS:
The CDC narrow and broad algorithms identified 5437 and 6317 cases, respectively, in the 4 years of KID weighted data. This yielded average annual incidences of 33.4 and 38.8 cases per 100 000 children &lt;1 year of age. There was no statistically significant change in national rates. There were variations by region of the country, with significantly different trends in the Midwest and West. State data for North Carolina showed wide annual variation in rates, with no significant trend.

CONCLUSIONS:
The new coding algorithm resulted in the highest AHT rates reported to date. At the same time, we found large but statistically insignificant annual variations in AHT rates in 1 large state. This suggests that caution should be used in interpreting AHT trends and attributing changes in rates as being caused by changes in policies, programs, or the economy.