bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progressive Pain Response in Idiopathic Clubfoot Children Undergoing Ponseti Casting: A Prospective Evaluation in 34 Feet
Authors: Barik Sitanshu , Agarwal Anil , Upadhyay Ankur , Patel Yogesh 
Published: July 2024

Background: Investigations of pain and physiologic responses response during Ponseti casting are in the preliminary stage. This short-term study aims to quantify pain responses and to note the variations, if any, during subsequent casting sessions.
Methods: In this prospective study, the pain parameters were evaluated in 34 clubfeet. Video recording of each casting session was performed 1 minute before casting, during casting, and after 1 minute of casting. The videos were scored objectively using Neonatal Infant Pain Score (NIPS). Heart rate (HR) and oxygen saturation were recorded by using a pulse oximeter.
Results: There was progressive increase in pain response until, at the last casting session, it was recorded as NIPS 4 (interquartile range, 1) (P = .02479). Before, during, and after casting, HR rose significantly in succeeding sessions. The mean HR during the first cast session was 175.5 ± 27.2/min, which increased to a mean of 197.3 ± 18.9/min (P = .000282). For the third parameter (oxygen saturation), no differences were observed between the first and last casting sessions.
Conclusions: There was moderate pain response during Ponseti casting sessions as demonstrated by the NIPS. It rose significantly toward the last cast. The clubfoot child showed an exaggerated heart rate in succeeding casting sessions. No variations were noticed for oxygen saturation.
Association between the metabolic score for insulin resistance and prostate cancer: a cross-sectional study in Xinjiang
Authors: Wang Jinru , Apizi Aireti , Tao Ning , An Hengqing 
Published: July 2024

Background
Insulin resistance is associated with the development and progression of various cancers. However, the epidemiological evidence for the association between insulin resistance and prostate cancer is still limited.

Objectives
To investigate the associations between insulin resistance and prostate cancer prevalence.

Methods
A total of 451 patients who were pathologically diagnosed with prostate cancer in the First Affiliated Hospital of Xinjiang Medical University were selected as the case population; 1,863 participants who conducted physical examinations during the same period were selected as the control population. The metabolic score for insulin resistance (METS-IR) was calculated as a substitute indicator for evaluating insulin resistance. The Chi-square test and Mann-Whitney U test were performed to compare the basic information of the case population and control population. Univariate and multivariate logistic regression analyses to define factors that may influence prostate cancer prevalence. The generalized additive model (GAM) was applied to fit the relationship between METS-IR and prostate cancer. Interaction tests based on generalized additive model (GAM) and contour plots were also carried out to analyze the interaction effect of each factor with METS-IR on prostate cancer.

Results
METS-IR as both a continuous and categorical variable suggested that METS-IR was negatively associated with prostate cancer prevalence. Smoothed curves fitted by generalized additive model (GAM) displayed a nonlinear correlation between METS-IR and prostate cancer prevalence (P < 0.001), and presented that METS-IR was negatively associated with the odds ratio (OR) of prostate cancer. The interaction based on the generalized additive model (GAM) revealed that METS-IR interacted with low-density lipoprotein cholesterol (LDL-c) to influence the prostate cancer prevalence (P = 0.004). Contour plots showed that the highest prevalence probability of prostate cancer was achieved when METS-IR was minimal and low-density lipoprotein cholesterol (LDL-c) or total cholesterol (TC) was maximal.

Conclusions
METS-IR is nonlinearly and negatively associated with the prevalence of prostate cancer. The interaction between METS-IR and low-density lipoprotein cholesterol (LDL-c) has an impact on the prevalence of prostate cancer. The study suggests that the causal relationship between insulin resistance and prostate cancer still needs more research to confirm.
Studies on Bio-chemical Attributes of Spiced Beetroot Ready-to-Serve (RTS) Beverage
Authors: Jat Vishvjeet Singh , Adhikary Kunal , Singh Vartika , Pandey Divya , Verma Satyavrat , Parmar Shipra Singh 
Published: July 2024

The study could be useful in determining how to use beetroot for juice production in order to reduce loss owing to underutilization, and the addition of spices can provide a distinct flavor while masking the earthy Odor of beetroot. The study was conducted at Post Harvest Laboratory, Department of Horticulture, School of Agriculture, ITM University, Gwalior. The experiment was laid in a Completely Randomized Design with fourteen treatment combinations and three replications in each treatment. The treatments consisted of several combinations of flavour with spices including various concentrations of Cumin, Cardamon, Cinnamon and Mint. Organoleptic attributes are the sensory parameters based on which, one can justify the taste, flavour and overall appearance of the product. From the conducted research trail, it has been observed that out of 11 treatments, T0 (Beet root (20 ml) + Sugar (10 g) + Water (80 ml)), showed least results. In the aspects of taste T0 ranked with the value of 5.67 followed by T2 6.67 at 0th day. From the conducted experimental trail, it has been observed that at final day the TSS was recorded highest value with 11.78 0B in T2 (Beet root (20 ml) + Sugar (10 g) + Water (80 ml) + Mint extract (10 ml)). Since the conducted experiment it has been found that Vit-C was recorded highest in T9 and T10, with the value of 6.13 and 6.43 mg/100ml. it has been assumed that by the addition of spices like cumin and cinnamon the vit-C content of the RTS was increased, which was future countered by the fermentation process at 3rd final day. The synergy between beetroot's betalains and mint's bioactive compounds could potentially amplify the overall health-promoting effects of the juice.
Analysis of fine ELF wave structures observed poleward from the ionospheric trough by the low‐altitude satellite DEMETER
Authors: Parrot Michel , Nĕmec František , Santolík Ondřej 
Published: March 2014

AbstractDEMETER was a three‐axis stabilized Earth‐pointing spacecraft launched on 29 June 2004 into a low‐altitude (710 km) polar and circular orbit that was subsequently lowered to 650 km until the end of the mission in December 2010. DEMETER measured electromagnetic waves all around the Earth except at magnetic invariant latitudes >65°. The frequency range for the electric field was from DC up to 3.5 MHz and for the magnetic field from a few hertz up to 20 kHz. Electromagnetic ion cyclotron (EMIC) waves have been previously observed by DEMETER close to the ionospheric trough during high magnetic activity, and this paper describes another type of EMIC waves. These waves are also observed close to the trough, but they extend poleward, with the trough acting as a boundary. They are observed exclusively during the night and preferentially during geomagnetic substorms. The analysis of wave propagation shows that they propagate nearly along the ambient magnetic field and that they come from larger radial distances.
New aspects of the ionospheric response to the October 2003 superstorms from multiple‐satellite observations
Authors: Lei Jiuhou , Wang Wenbin , Burns Alan G. , Yue Xinan , Dou Xiankang , Luan Xiaoli , Solomon Stanley C. , Liu Yong C.‐M. 
Published: March 2014

AbstractThe total electron content (TEC) data measured by the Jason, CHAMP, GRACE, and SAC‐C satellites, the in situ electron densities from CHAMP and GRACE, and the vertical E × B drifts from the ROCSAT, have been utilized to examine the ionospheric response to the October 2003 superstorms. The combination of observations from multiple satellites provides a unique global view of ionospheric storm effects, especially over the Pacific Ocean and American regions, which were under sunlit conditions during the main phases of the October 2003 superstorms. The main results of this study are as follows: (1) There were substantial increases in TEC in the daytime at low and middle latitudes during both superstorms. (2) The enhancements were greater during the 30 October superstorm and occurred over a wider range of local times. (3) They also tended to peak at earlier local times during this second event. (4) These TEC enhancement events occurred at the local times when there were enhancements in the upward vertical drift. (5) The strong upward vertical drifts are attributed to penetration electric fields, suggesting that these penetration electric fields played a significant role in the electron density enhancements during these superstorms. Overall, the main contribution of this study is the simultaneous view of the storm time ionospheric response from multiple satellites, and the association of local time differences in ionospheric plasma response with measured vertical drift variations.
Path dependence of the potential for compaction banding: Theoretical predictions based on a plasticity model for porous rocks
Authors: Buscarnera Giuseppe , Laverack Reed T. 
Published: March 2014

AbstractThe paper presents a theoretical investigation of compaction banding based on a plasticity model for high‐porosity rocks. The selected model is featured by a nonassociated flow rule and two internal variables simulating the competition between softening and hardening in the brittle‐ductile transition. The parameters have been calibrated for two extensively studied rocks that exhibited localized compaction under laboratory conditions. In particular, the constants that control the compaction banding domain are defined by matching the stresses at which localized compaction was found in the experiments. The resulting parameters are used to simulate the stress‐strain response for two loading modes (i.e., triaxial compression and radially constrained deformation), thus exploring the role of stress paths and kinematic constraints on the evolution of the compaction banding potential. The analyses suggest that the loading paths able to mobilize the plastic resources of the rock alter the potential for compaction banding through irreversible effects. A notable example is oedometric compression, for which the potential to generate localized compaction tends to vanish during the initial stages of inelastic loading. These predictions suggest that constraints to the mode of deformation can hinder the occurrence of compaction bands in the field. Moreover, they suggest that the interplay between kinematic constraints and evolution of the compaction banding potential can be used for experimental characterization purposes. As a consequence, these results emphasize the importance of complementing stress‐controlled experiments with other tests able to explore different stress paths, thus providing additional data for an accurate characterization of rheological properties and strain‐localization characteristics.
Key parameters controlling OH‐initiated formation of secondary organic aerosol in the aqueous phase (aqSOA)
Authors: Ervens Barbara , Sorooshian Armin , Lim Yong B. , Turpin Barbara J. 
Published: March 2014

AbstractSecondary organic aerosol formation in the aqueous phase of cloud droplets and aerosol particles (aqSOA) might contribute substantially to the total SOA burden and help to explain discrepancies between observed and predicted SOA properties. In order to implement aqSOA formation in models, key processes controlling formation within the multiphase system have to be identified. We explore parameters affecting phase transfer and OH(aq)‐initiated aqSOA formation as a function of OH(aq) availability. Box model results suggest OH(aq)‐limited photochemical aqSOA formation in cloud water even if aqueous OH(aq) sources are present. This limitation manifests itself as an apparent surface dependence of aqSOA formation. We estimate chemical OH(aq) production fluxes, necessary to establish thermodynamic equilibrium between the phases (based on Henry's law constants) for both cloud and aqueous particles. Estimates show that no (currently known) OH(aq) source in cloud water can remove this limitation, whereas in aerosol water, it might be feasible. Ambient organic mass (oxalate) measurements in stratocumulus clouds as a function of cloud drop surface area and liquid water content exhibit trends similar to model results. These findings support the use of parameterizations of cloud‐aqSOA using effective droplet radius rather than liquid water volume or drop surface area. Sensitivity studies suggest that future laboratory studies should explore aqSOA yields in multiphase systems as a function of these parameters and at atmospherically relevant OH(aq) levels. Since aerosol‐aqSOA formation significantly depends on OH(aq) availability, parameterizations might be less straightforward, and oxidant (OH) sources within aerosol water emerge as one of the major uncertainties in aerosol‐aqSOA formation.
Asymmetric Synthesis of Tetrahydroquinolines via Saegusa‐type Oxidative Enamine Catalysis/1,5‐Hydride Transfer/Cyclization Sequences
Authors: Suh Chang Won , Woo Saet Byeol , Kim Dae Young 
Published: March 2014

AbstractEnantioselective organocatalytic synthesis of tetrahydroquinolines has been achieved via Saegusa‐type oxidative enamine catalysis/1,5‐hydride transfer/cyclization sequences. The feature of this research is a one‐pot transformation of 3‐aryl aldehydes into tetrahydroquinolines by using environmentally benign catalytic Saegusa oxidation and highly efficient internal redox reactions. The synthetically useful ring‐fused tetrahydroquinoline derivatives were obtained in moderate yields and high levels of enantioselectivity.
Organocatalytic Enantio‐ and Diastereoselective Assembly of Thiazolidine Scaffolds by Formal [3+2] Annulation
Authors: Qian Hui , Sun Jianwei 
Published: March 2014

AbstractAn organocatalytic enantio‐ and diastereoselective formal [3+2] annulation between imines and 1,4‐dithiane‐2,5‐diol is disclosed. The reaction provides rapid access to chiral thiazolidine‐based molecules starting from a readily available catalyst and achiral starting materials.
Aggregation, interregional interaction, and postmarital residence patterning: A study of biological variation in the late prehistoric middle Ohio Valley
Authors: Cook Robert A. , Aubry B. Scott 
Published: March 2014

ABSTRACTThis study examines a perennial problem in anthropology, changes in postmarital residence patterning. Cross‐cultural patterns related to shifts from patrilocal to matrilocal patterns have been attributed to changes in subsistence and/or the result of migrants entering a populated region. Shifts from matrilocal to multilocal patterns have been found to be related to depopulation. This study examines these possibilities in an archeological context through morphometric analyses of human dentition. Comparisons in variability among males and females are made at four Fort Ancient sites in the Middle Ohio Valley that date to sequential time periods between circa A.D. 1000 and 1650. Results show that the earliest site (Turpin) that was occupied during the transition to maize agriculture was patrilocal, whereas two subsequent sites (Anderson and SunWatch) that were occupied after the transition to a maize‐focused diet reflect a matrilocal pattern. The most recently occupied site (Madisonville), occupied during a time of depopulation of the region after a decline in levels of maize consumption and a marked population shuffling contains a multilocal pattern. These results fit well with the various cross‐cultural findings regarding shifts in postmarital residence patterns. Am J Phys Anthropol 154:270–278, 2014. © 2014 Wiley Periodicals, Inc.
Case‐control analysis of survival outcomes in sinonasal acinic cell carcinoma
Authors: Biron Vincent L. , Lentsch Eric J. , Gerry Daniel R. , Bewley Arnaud F. 
Published: March 2014

BackgroundAcinic cell carcinoma (AciCC) is an uncommon malignant‐epithelial salivary gland cancer. In very rare cases, this tumor may arise from sinonasal subsites, with only 19 cases described in the English‐language literature.MethodsWe performed a retrospective analysis of 18 cases of AciCC, obtained from searching the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2009.ResultsPatient demographics, including age, gender, and race, were similar to AciCC cases found in more common locations. However, all patients had low‐grade tumors without regional or distant metastases. Comparing these patients to a stage, grade, and treatment–matched cohort of parotid AciCC, we found a lower 10‐year overall survival (52.3%) with no significant difference in disease‐specific survival (88.9%). Our meta‐analysis of survival from cases in the literature estimated 10‐year recurrence‐free survival at 92.9%.ConclusionTo our knowledge, this is the largest cohort of patients with AciCC reported in the English‐language literature. Our results suggest that patients with sinonasal AciCC have excellent disease‐specific survival, comparable to matched patients with AciCC in more common salivary gland subsites.
Inverse Opalkugeln basierend auf polyionischen Flüssigkeiten als funktionelle Mikrokugeln mit steuerbaren optischen Eigenschaften und der Fähigkeit zur molekularen Erkennung
Authors: Cui Jiecheng , Zhu Wei , Gao Ning , Li Jian , Yang Haowei , Jiang Yin , Seidel Philipp , Ravoo Bart Jan , Li Guangtao 
Published: March 2014

AbstractBasierend auf der Kombination der einzigartigen Eigenschaften von polyionischen Flüssigkeiten und kugelförmigen, kolloidalen Kristallen wurde eine neue Klasse von Opalkugeln mit einer Reihe besonderer Eigenschaften hergestellt. Diese photonischen Kugeln konnten nicht nur als responsive photonische Mikrogele verwendet werden, sondern auch als multifunktionelle Mikrokugeln, die die Haupteigenschaften herkömmlicher Moleküle wie optische Eigenschaften, spezifische molekulare Erkennung, Reaktivität, Derivatisierung und Anisotropie nachahmen.
Inverse Opal Spheres Based on Polyionic Liquids as Functional Microspheres with Tunable Optical Properties and Molecular Recognition Capabilities
Authors: Cui Jiecheng , Zhu Wei , Gao Ning , Li Jian , Yang Haowei , Jiang Yin , Seidel Philipp , Ravoo Bart Jan , Li Guangtao 
Published: March 2014

AbstractBased on the combination of the unique features of both polyionic liquids and spherical colloidal crystals, a new class of inverse opaline spheres with a series of distinct properties was fabricated. It was found that such photonic spheres could not only be used as stimuli‐responsive photonic microgels, but also serve as multifunctional microspheres that mimic the main characteristics of conventional molecules, including intrinsic optical properties, specific molecular recognition, reactivity and derivatization, and anisotropy.
Substrate Specificity and Stereoselectivity of Two Sulfolobus 2‐Keto‐3‐deoxygluconate Aldolases towards Azido‐Substituted Aldehydes
Authors: Schurink Marloes , Wolterink‐van Loo Suzanne , van der Oost John , Sonke Theo , Franssen Maurice C. R. 
Published: March 2014

AbstractThe 2‐keto‐3‐deoxygluconate aldolases (KDGAs) isolated from Sulfolobus species convert pyruvate and glyceraldehyde reversibly into 2‐keto‐3‐deoxygluconate and ‐galactonate. As a result of their high thermostability and activity on nonphosphorylated substrates, KDGA enzymes have potential as biocatalysts for the production of building blocks for fine chemical and pharmaceutical applications. Up to now, wild‐type enzymes have only shown moderate stereocontrol for their natural reaction. However, if a set of azido‐functionalized aldehydes were applied as alternative acceptors in the reaction with pyruvate, the stereoselectivity was strongly increased to give enantiomeric or diastereomeric excess values up to 97 %. The Sulfolobus acidocaldarius KDGA displayed a higher stereoselectivity than Sulfolobus solfataricus KDGA for all tested reactions. The azido‐containing products are useful chiral intermediates in the synthesis of nitrogen heterocycles.
Water‐Resistant Poly(vinyl alcohol)‐Silica Hybrids through Sol‐Gel Processing
Authors: Pirzada Tahira , Shah Syed Sakhawat 
Published: March 2014

AbstractPoly(vinyl alcohol) (PVA)‐silica hybrids with exceptionally reduced solubility in water were synthesized. The hybrid xerogels were fabricated through sol‐gel processing of a mixture of PVA and the acid‐catalyzed silica precursor tetraethoxysilane. The effects of varying ratios of PVA and silica precursor on the surface structure, thermal properties, crystallinity, and solubility of the hybrids were investigated. Unlike the highly water‐soluble nature of PVA, all the hybrids displayed considerably reduced solubility in water. This anomalous behavior of PVA in the hybrids can be attributed to the unavailability of its pendant –OH groups. Water‐resistant PVA‐silica hybrids can find applications in various technologies requiring biocompatible systems that are stable in aqueous environments.
A Supramolecular Vesicle Based on the Complexation of p‐Sulfonatocalixarene with Protamine and its Trypsin‐Triggered Controllable‐Release Properties
Authors: Wang Kui , Guo Dong‐Sheng , Zhao Meng‐Yao , Liu Yu 
Published: March 2014

AbstractEnzyme‐responsive assembly represents one of the increasingly significant topics in biomaterials research and finds feasible applications to the controlled release of therapeutic agents at specific sites at which the target enzymes are located. In this work, based on the concept of host–guest chemistry, a trypsin‐responsive supramolecular vesicle using p‐sulfonatocalix[4]arene as the macrocyclic host and natural serine protease trypsin‐cleavable cationic protein protamine as the guest molecule, is reported. The complexation of p‐sulfonatocalix[4]arene with protamine directs the formation of a supramolecular binary vesicle, which is dissipated by trypsin with high selectivity. Therefore, the present system represents a principle‐of‐concept to build a controlled‐release carrier at trypsin‐overexpressed sites.
The Synthesis of Functionalised Diaryltetraynes and Their Transport Properties in Single‐Molecule Junctions
Authors: Gulcur Murat , Moreno‐García Pavel , Zhao Xiaotao , Baghernejad Masoud , Batsanov Andrei S. , Hong Wenjing , Bryce Martin R. , Wandlowski Thomas 
Published: March 2014

AbstractThe synthesis and characterisation is described of six diaryltetrayne derivatives [Ar‐(CC)4‐Ar] with Ar=4‐NO2‐C6H4‐ (NO24), 4‐NH(Me)C6H4‐ (NHMe4), 4‐NMe2C6H4‐ (NMe24), 4‐NH2‐(2,6‐dimethyl)C6H4‐ (DMeNH24), 5‐indolyl (IN4) and 5‐benzothienyl (BTh4). X‐ray molecular structures are reported for NO24, NHMe4, DMeNH24, IN4 and BTh4. The stability of the tetraynes has been assessed under ambient laboratory conditions (20 °C, daylight and in air): NO24 and BTh4 are stable for at least six months without observable decomposition, whereas NHMe4, NMe24, DMeNH24 and IN4 decompose within a few hours or days. The derivative DMeNH24, with ortho‐methyl groups partially shielding the tetrayne backbone, is considerably more stable than the parent compound with Ar=4‐NH2C6H4 (NH24). The ability of the stable tetraynes to anchor in Au|molecule|Au junctions is reported. Scanning‐tunnelling‐microscopy break junction (STM‐BJ) and mechanically controllable break junction (MCBJ) techniques are employed to investigate single‐molecule conductance characteristics.