bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analysis of the psychometric properties of the medication safety competence scale in Turkish
Authors: Aydinli Ayşe , Cerit Kamuran 
Published: August 2024

Abstract
Purpose
Considering the key roles and responsibilities of nurses in ensuring medication safety, it is necessary to understand nurses’ competence in medication safety. Therefore, it was aimed to introduce a scale evaluating the medication safety competence of nurses into Turkish and to contribute to the literature by determining the medication safety competence levels of nurses.

Methods
A methodological and descriptive research design was utilised. The population consisted of nurses in Turkey, and the sample comprised 523 nurses who volunteered to participate.

Results
The content validity index of the scale was 0.98, and the scale showed a good fit (χ2/df = 3.00, RMSEA = 0.062). The Cronbach’s alpha coefficient of the scale was 0.97, indicating high reliability. The mean score was 4.12, which was considered high. Participants who were 40 years old or above, married, and graduates of health vocational schools or postgraduate programs, along with those who had received medication safety training, had higher medication safety competence scores.

Conclusion
This study presents strong evidence that the Turkish version of the Medication Safety Competency Scale is valid and reliable when administered to nurses. The participants in this study had high levels of medication safety competence.
Cancer incidence and mortality after a first-ever venous thrombosis: a cohort study in northern Sweden
Authors: Hägg Lovisa , Ehrs Felicia , Lind Marcus , Johansson Magdalena 
Published: August 2024

Abstract
Background
Venous thromboembolism (VTE) has a high mortality rate and can be the first manifestation of cancer. We investigated the incidence of cancer after first-ever VTE and the association between VTE and all-cause mortality.

Methods
A Swedish cohort study that included 105,997 participants without previous cancer who underwent a health examination from 1985–2014 was conducted. Manually validated first-ever VTE events, incident cancer according to the Swedish cancer registry, and mortality were registered. Participants were followed until September 5, 2014.

Results
The mean age at inclusion was 46.2 years, and 50.3% of participants were female. We identified 1303 persons in the cohort with a VTE and no previous cancer. Among these, 179 (13.7%) were diagnosed with cancer after the VTE event, resulting in a cancer incidence of 26.4 (95% CI 22.8–30.6) cases per 1000 person-years. The incidence was highest during the first 6 months after the VTE. In the study population, VTE was associated with an increased risk of cancer (HR 1.95 [95% CI 1.67–2.29] in a multivariable model). VTE was also associated with an increased risk of death (HR 6.30 [95% CI 5.82–6.81]) in a multivariable model). There was an interaction between sex and VTE in relation to both risk of cancer and mortality, with a stronger association in women.

Conclusions
The incidence of cancer is high after first-ever VTE, especially close to the VTE event. VTE seems to be a stronger risk marker in women than in men for both cancer and death.
Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics
Authors: Feng Yupiao , Hu Xinting , Wang Xin 
Published: August 2024

AbstractTargeted therapies, such as small molecule kinase inhibitors, have made significant progress in the treatment of hematologic malignancies by directly modulating protein activity. However, issues such as drug toxicity, drug resistance due to target mutations, and the absence of key active sites limit the therapeutic efficacy of these drugs. Targeted protein degradation (TPD) presents an emergent and rapidly evolving therapeutic approach that selectively targets proteins of interest (POI) based on endogenous degradation processes. With an event-driven pharmacology of action, TPD achieves efficacy with catalytic amounts, avoiding drug-related toxicity. Furthermore, TPD has the unique mode of degrading the entire POI, such that resistance derived from mutations in the targeted protein has less impact on its degradation function. Proteolysis-targeting chimeras (PROTACs) and molecular glue degraders (MGDs) are the most maturely developed TPD techniques. In this review, we focus on both preclinical experiments and clinical trials to provide a comprehensive summary of the safety and clinical effectiveness of PROTACs and MGDs in hematologic malignancies over the past two decades. In addition, we also delineate the challenges and opportunities associated with these burgeoning degradation techniques. TPD, as an approach to the precise degradation of specific proteins, provides an important impetus for its future application in the treatment of patients with hematologic malignancies.
Characterization of caseinate-pectin complex coacervates as a carrier for delivery and controlled-release of saffron extract
Authors: Ardestani Faezeh , Haghighi Asl Ali , Rafe Ali 
Published: August 2024

AbstractIn this work, microcapsules were developed by the complex coacervation of sodium caseinate and pectin as a carrier for saffron extract. Parameters such as Zeta potential, dynamic light scattering, and microscopic techniques were investigated for their influence on the formation of these complexes. Furthermore, Fourier transform infrared (FTIR) analysis confirmed the reaction mechanism between the protein and tannic acid or saffron extract. The study revealed that core/shell and protein/polysaccharide (Pr/Ps) ratios play a role in the encapsulation efficiency (EE) and loading capacity (LC) of saffron extract, with EE and LC ranging from 48.36 to 89.38% and 1.14 to 5.55%, respectively. Thermal gravimetric analysis revealed that the degradation temperature of saffron increased significantly with microencapsulation. The use of tannic acid for hardening the microcapsules led to an increase in size from 13 μm to 27 μm. Rheological findings indicated that shear-thinning behavior in the coacervates, with cross-linking, has a minor effect on the interconnected elastic gel structures. However, cross-linking improved the microcapsules' thermal and structural properties. The increase in polymer chain length due to cross-linking and the presence of the guest molecule (saffron extract) resulted in higher rheological moduli, reflecting enhanced entanglements and correlating well with the thermal, structural, and microstructural properties of the coacervates. Kinetic release studies showed a slower release in the gastric phase compared to the intestinal phase, with the Ritger–Peppas model effectively describing saffron extract release, highlighting a dominant swelling and dissolution release mechanism. Therefore, the NaCas/HMP coacervate wall materials made saffron stable in the gastric stage and sustainably release. It in the intestinal stage, promoting excellent absorption of saffron in simulated digestion.
Graphical Abstract
Complications associated with kidney transplantation, causes of graft failure and mortality following kidney transplantation in patients with systemic lupus erythematosus: a meta-analysis
Authors: Li Xin , Cao Chun Xiang , Chen Jian 
Published: August 2024

Abstract
Introduction
Despite improvement in the management of systemic lupus erythematosus (SLE) during the past two decades, 10–22% of patients with lupus nephritis (LN) will progress to end-stage renal disease (ESRD). Kidney transplantation is among the possible treatment for patients with SLE progressing to ESRD. However, the issue with kidney transplantation in patients with SLE is controversial. In this analysis, we aimed to compare the complications associated with kidney transplantation, causes of graft failure and causes of mortality following kidney transplantation in patients with SLE with ESRD.

Methods
The sources of data included http://www.ClinicalTrials.gov, EMBASE, MEDLINE, Google Scholar, Web of Science and the Cochrane database. Revman software version 5.4 was used for the data analysis whereby risk ratio (RR) with 95% confidence intervals (CI) were used to represent data following analysis. In addition, the Q statistic test and the I2 statistic test were used to assess heterogeneity. A random effect statistical model was used and a subgroup outcome with a P-value less than 0.05 was considered statistically significant.

Results
A total number of 149,330 participants enrolled between the years 1968 and 2018 were included in this analysis with 7534 participants with SLE.
Results of this analysis showed that mortality (RR 1.07, 95% CI 0.89–1.29; P = 0.45), graft failure (RR 1.22, 95% CI 0.99–1.55; P = 0.07) and delayed graft function (RR 1.01, 95% CI 0.44–2.34; P = 0.98) were not significantly higher in renal transplant patients with SLE versus a control group. When the causes of graft failure were analysed in renal transplant patients with SLE versus without SLE, acute graft rejection (RR 1.20, 95% CI 0.98–1.47; P = 0.07), chronic graft rejection (RR 0.76, 95% CI 0.57–1.03; P = 0.08), graft thrombosis (RR 1.47, 95% CI 0.83–2.63; P = 0.19), recurrence of disease (RR 3.08, 95% CI 1.00–9.47; P = 0.05) and chronic allograft nephropathy (RR 1.08, 95% CI 0.60–1.95; P = 0.80) were also not significantly higher in patients with SLE. On the basis of the analysis, mortality from any cardiac cause (RR 0.82, 95% CI 0.67–1.01; P = 0.06), sepsis (RR 1.19, 95% CI 0.93–1.53; P = 0.17), malignancy (RR 0.79, 95% CI 0.51–1.24; P = 0.31) and cerebrovascular attack (RR 0.76, 95% CI 0.44–1.30; P = 0.31) were not significantly different in kidney transplantation patients with versus without SLE.

Conclusions
Complications associated with kidney transplantation including mortality, graft failure and delayed graft function were not significantly higher in patients with SLE when compared with a control group. The causes of graft failure and mortality after kidney transplantation were also comparable in both groups. Therefore, kidney transplantation represents a promising treatment in patients with SLE with ESRD.
40 years of the homeobox: mechanisms of Hox spatial-temporal collinearity in vertebrates
Authors: Peraldi Rodrigue , Kmita Marie 
Published: August 2024

ABSTRACT
Animal body plans are established during embryonic development by the Hox genes. This patterning process relies on the differential expression of Hox genes along the head-to-tail axis. Hox spatial collinearity refers to the relationship between the organization of Hox genes in clusters and the differential Hox expression, whereby the relative order of the Hox genes within a cluster mirrors the spatial sequence of expression in the developing embryo. In vertebrates, the cluster organization is also associated with the timing of Hox activation, which harmonizes Hox expression with the progressive emergence of axial tissues. Thereby, in vertebrates, Hox temporal collinearity is intimately linked to Hox spatial collinearity. Understanding the mechanisms contributing to Hox temporal and spatial collinearity is thus key to the comprehension of vertebrate patterning. Here, we provide an overview of the main discoveries pertaining to the mechanisms of Hox spatial-temporal collinearity.
Dual role of BdMUTE during stomatal development in the model grass Brachypodium distachyon
Authors: Spiegelhalder Roxane P. , Berg Lea S. , Nunes Tiago D. G. , Dörr Melanie , Jesenofsky Barbara , Lindner Heike , Raissig Michael T. 
Published: August 2024

ABSTRACT
Grasses form morphologically derived, four-celled stomata, where two dumbbell-shaped guard cells (GCs) are flanked by two lateral subsidiary cells (SCs). This innovative form enables rapid opening and closing kinetics and efficient plant–atmosphere gas exchange. The mobile bHLH transcription factor MUTE is required for SC formation in grasses. Yet whether and how MUTE also regulates GC development and whether MUTE mobility is required for SC recruitment is unclear. Here, we transgenically impaired BdMUTE mobility from GC to SC precursors in the emerging model grass Brachypodium distachyon. Our data indicate that reduced BdMUTE mobility severely affected the spatiotemporal coordination of GC and SC development. Furthermore, although BdMUTE has a cell-autonomous role in GC division orientation, complete dumbbell morphogenesis of GCs required SC recruitment. Finally, leaf-level gas exchange measurements showed that dosage-dependent complementation of the four-celled grass morphology was mirrored in a gradual physiological complementation of stomatal kinetics. Together, our work revealed a dual role of grass MUTE in regulating GC division orientation and SC recruitment, which in turn is required for GC morphogenesis and the rapid kinetics of grass stomata.
Core Temperature Response to Cold Water Immersion in Heat Stroke Patients Is Nonlinear and Unrelated to Sex or Body Size
Authors: BONGERS COEN C. W. G. , PEGGEN MANDY A. G. , MINETT GEOFFREY M. , KRUIJT NICK , GORIS BRAM , HOPMAN MARIA T. E. 
Published: August 2024

ABSTRACT

Purpose
Cold water immersion (CWI) is the most effective treatment for exertional heat stroke (EHS). However, knowledge on core temperature response during CWI treatment and the relation with patient characteristics (i.e., sex, anthropometrics) is limited. Therefore, the current study aimed to examine the core temperature response (in °C) during CWI treatment of recreational athletes participating in large running events and investigate the impact of sex and anthropometric characteristics on the cooling rate (in °C·min−1).

Methods
This observational study includes 57 athletes (n = 22 females; 39%) who suffered from EHS during an exercise event in the Netherlands. After admission to the medical facilities, a rectal temperature (T
rec) probe was inserted and all clothing was removed before immersion in an ice bath (6.4 ± 1.6°C). Rectal temperature was continuously measured throughout treatment, and treatment was continued until T
rec ≤ 38.9°C or based on the decision of the emergency physician.

Results
Initial T
rec did not differ between males (41.3 ± 0.9°C) and females (41.2 ± 0.8°C, P = 0.83). A nonlinear response to CWI was observed, with the decrease in T
rec beginning after 6 min of CWI. The decrease in T
rec did not differ between both sexes (ptime*sex = 0.96). The cooling rate did not differ between males (0.21 ± 0.15°C·min−1) and females (0.19 ± 0.08°C·min−1, P = 0.55), and was not related to body mass, body surface area and body surface area to mass ratio (all P values >0.05).

Conclusions
We demonstrated that the cooling rate during CWI did not differ between men and women suffering from EHS, and that the T
rec response to CWI is nonlinear and not dependent on anthropometric characteristics. This suggests that no sex differentiation is needed in the EHS treatment guidelines and confirms the necessity to continuously monitor T
rec during treatment.
Impact of microplastics on human health: exposure mechanisms and potential health implications
Authors: Marszalek Anna , Marzec Weronika Zofia , Łakoma Aleksandra , Marzec Marcelina Teresa , Choiński Maciej , Wasiewicz-Ciach Paulina , Kuczyński Piotr , Wydra-Rojek Aleksandra , Kutyła Katarzyna , Mokot Wojciech Jan 
Published: August 2024

Microplastics are a pervasive environmental contaminant and represent a newly emerging threat to human health. They enter the body through various pathways, including food consumption, drinking water, and inhalation. The present study is concerned with the issue of dietary and inhalational exposure to microplastics. The presence of microplastics has been identified in a range of food products and drinking water, with analyses of faecal samples also indicating their passage through the human digestive tract, thereby suggesting the potential for their absorption by the body. It is also important to consider the potential for inhalational exposure, given the presence of microplastics in the air. This suggests that inhalation by humans may also be a possibility. Furthermore, these particles have been identified in sputum samples from patients and lung tissues, indicating the potential for bioaccumulation and the induction of inflammatory responses.
While there is documented evidence of microplastics in the human body, there is currently a lack of specific data on their impact on human health. The available evidence from animal studies and in vitro models indicates that microplastics have the potential to traverse epithelial barriers in the digestive and respiratory systems, resulting in inflammatory responses, oxidative stress, and, in extreme cases, tissue fibrosis. Furthermore, microplastics may act as carriers for heavy metals and toxic chemicals, thereby increasing the risk of neurotoxicity, nephrotoxicity, and potentially carcinogenic effects. Further research, including long-term clinical studies, is required to gain a full understanding of the impact of microplastics on human health.
A Bilevel Approach for Compensation and Routing Decisions in Last-Mile Delivery
Authors: Cerulli Martina , Archetti Claudia , Fernández Elena , Ljubić Ivana 
Published: August 2024

In last-mile delivery logistics, peer-to-peer logistic platforms play an important role in connecting senders, customers, and independent carriers to fulfill delivery requests. As the carriers are not under the platform’s control, the platform has to anticipate their reactions while deciding how to allocate the delivery operations. Indeed, carriers’ decisions largely affect the platform’s revenue. In this paper, we model this problem using bilevel programming. At the upper level, the platform decides how to assign the orders to the carriers; at the lower level, each carrier solves a profitable tour problem to determine which offered requests to accept, based on her own profit maximization. Possibly, the platform can influence carriers’ decisions by determining also the compensation paid for each accepted request. The two considered settings result in two different formulations: the bilevel profitable tour problem with fixed compensation margins and with margin decisions, respectively. For each of them, we propose single-level reformulations and alternative formulations where the lower-level routing variables are projected out. A branch-and-cut algorithm is proposed to solve the bilevel models, with a tailored warm-start heuristic used to speed up the solution process. Extensive computational tests are performed to compare the proposed formulations and analyze solution characteristics. Funding: The research of E. Fernandez was partially funded through the Spanish Ministerio de Ciencia y Tecnología and European Regional Development Funds (ERDF) [Grant MTM2019-105824GB-I00]. The research of C. Archetti, M. Cerulli, and I. Ljubić was partially funded by CY Initiative of Excellence, France [Grant “Investissements d’Avenir ANR-16-IDEX-0008”]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2023.0129 .
Knowledge, attitude, prevention practice and lived experience towards cutaneous leishmaniasis and associated factors among residents of Kutaber district, Northeast Ethiopia, 2022: A mixed method study
Authors: Geto Abebe Kassa , Malede Asmamaw , Lingerew Mistir , Bitew Abie Alebachew , Berihun Gete , Ademas Ayechew , Berhanu Leykun , Kassaw Genanew Mulugeta , Wogayehu Belachew Tekleyohannes , Adane Metadel 
Published: August 2024

Background
Cutaneous leishmaniasis is a widespread parasitic infection in Ethiopia. Few studies have been conducted on knowledge, attitudes, and prevention practice related to cutaneous leishmaniasis, and the existing studies have been mainly without qualitative support. This study aimed to assess the knowledge, attitude, prevention practice and lived experience towards cutaneous leishmaniasis and associated factors among residents of the Kutaber district, Northeast Ethiopia.

Methods
A convergent parallel mixed method was conducted among 636 residents (for quantitative) and 20 in-depth interview participants (for qualitative) of the Kutaber district from July 1 to August 15, 2022. Quantitative data were entered into Epi-Data version 4.6 and exported to SPSS version 25 for cleaning and analysis. ATLAS.ti software version 8.0 was used for the analysis of qualitative data.

Results
The survey respondents in Kutaber district showed good knowledge (47.5%), a positive attitude towards (54.1%) and a good prevention practice (35.3%) regarding cutaneous leishmaniasis. Residents who were unable to read and write [AOR = 0.15] had lower odds to have good knowledge about cutaneous leishmaniasis. Residents aged >54.5 years [AOR = 0.33] had lower odds to have a positive attitude towards cutaneous leishmaniasis. Males [AOR = 1.76] had a good prevention practice towards cutaneous leishmaniasis. Five main study themes were formed following the qualitative analysis of the data.

Conclusion
Residents of Kutaber district have a poor overall knowledge and prevention practice towards cutaneous leishmaniasis, despite having a positive attitude. The educational status of residents and years of residence were factors significantly associated with knowledge about cutaneous leishmaniasis. Age and years of residence were factors significantly associated with attitude towards cutaneous leishmaniasis. Gender, age, and household wealth were factors significantly associated with prevention practice towards cutaneous leishmaniasis. Cutaneous leishmaniasis in Kutaber is a true health problem.
A systematic review of exergame usability as home-based balance training tool for older adults usability of exergames as home-based balance training
Authors: Medeiros Candice Simões Pimenta de , Farias Luanna Bárbara Araújo , Santana Maria Clara do Lago , Pacheco Thaiana Barbosa Ferreira , Dantas Rummenigge Rudson , Cavalcanti Fabrícia Azevedo da Costa 
Published: August 2024

Background
Exergames are a fun, viable, attractive, and safe way to engage in physical exercise for most patient populations, including older adults. Their use in the home environment enables an expanded understanding about its applicability and its impact on clinical outcomes that can contribute to improved functionality and quality of life in this population. This systematic review aimed to synthesize the evidence on the usability of exergames as a tool for home-based balance training in older adults.

Methods
The search was realized in 6 electronic databases and were included 1) randomized controlled trials with exergames home-based training as intervention, 2) studies involving older adults (aged 60 years or older) described as having impaired static or dynamic balance, 3) that compared the effects of exergames to usual care, health education or no intervention, and 4) reported usability and balance outcomes. The Cochrane Risk of Bias tool for randomized trials version 2 and the Grading of Recommendations Assessment, Development, and Evaluation were used to evaluate the methodological quality of studies and levels of evidence for outcomes.

Results
After screening 1107 records, we identified 4 trials were included. The usability score of exergames was classified as an acceptable, good, and feasible tool. The pooled effect indicated improvements in favor of the exergame group for functional balance by TUG test (MD = -5.90; 95%CI = -10.29 to -1.51) with low-certainty evidence and Tinetti scale (MD = 4.80; 95%CI = 3.36 to 6.24) with very low-certainty evidence. Analyzing the different immersion level, it was observed a significant difference in the experimental group for the immersive exergames (MD = -9.14; 95%CI = -15.51 to -2.77) with very low-certainty evidence.

Conclusion
Exergames applied at home showed good usability and had significant effects on functional balance compared to usual care or no intervention, especially in the immersive modality.

Trial registration
PROSPERO registration number: CRD42022343290.