bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female Gender and Diabetes Mellitus Increase the Risk of Recurrence after Laparoscopic Incisional Hernia Repair
Authors: Hornby ST , McDermott FD , Coleman M , Ahmed Z , Bunni J , Bunting D , Elshaer M , Evans V , Kimble A , Kostalas M , Page G , Singh J , Szczebiot L , Wienand-Barnett S , Wilkins A , Williams O , Newell P 
Published: February 2015

Background Laparoscopic hernia repair is used widely for the repair of incisional hernias. Few case studies have focussed on purely ‘incisional’ hernias. This multicentre series represents a collaborative effort and employed statistical analyses to provide insight into the factors predisposing to recurrence of incisional hernia after laparoscopic repair. A specific hypothesis (ie, laterality of hernias as well as proximity to the xyphoid process and pubic symphysis predisposes to recurrence) was also tested. Methods This was a retrospective study of all laparoscopic incisional hernias undertaken in six centres from 1 January 2004 to 31 December 2010. It comprised a comprehensive review of case notes and a follow-up using a structured telephone questionnaire. Patient demographics, previous medical/surgical history, surgical procedure, postoperative recovery, and perceived effect on quality of life were recorded. Repairs undertaken for primary ventral hernias were excluded. A logistic regression analysis was then fitted with recurrence as the primary outcome. Results A total of 186 cases (91 females) were identified. Median follow-up was 42 months. Telephone interviews were answered by 115/186 (62%) of subjects. Logistic regression analyses suggested that only female sex (odds ratio (OR) 3.53; 95% confidence interval (CI) 1.39–8.97) and diabetes mellitus (3.54; 1–12.56) significantly increased the risk of recurrence. Position of the defect had no statistical effect. Conclusions These data suggest an increased risk of recurrence after laparoscopic incisional hernia repair in females and subjects with diabetes mellitus. These data will help inform surgeons and patients when considering laparoscopic management of incisional hernias. We recommend a centrally hosted, prospectively maintained national/international database to carry out additional research.
The Current Role of Staging Laparoscopy in Oesophagogastric Cancer
Authors: Convie L , Thompson RJ , Kennedy R , Clements WDB , Carey PD , Kennedy JA 
Published: February 2015

Introduction Oesophagogastric cancers are known to spread rapidly to locoregional lymph nodes and by transcoelomic spread to the peritoneal cavity. Staging laparoscopy combined with peritoneal cytology can detect advanced disease that may not be apparent on other staging investigations. The aim of this study was to determine the current value of staging laparoscopy and peritoneal cytology in light of the ubiquitous use of computed tomography in all oesophagogastric cancers and the addition of positron emission tomography in oesophageal cancer. Methods All patients undergoing staging laparoscopy for distal oesophageal or gastric cancer between March 2007 and August 2013 were identified from a prospectively maintained database. Demographic details, preoperative staging, staging laparoscopy findings, cytology and histopathology results were analysed. Results A total of 317 patients were identified: 159 (50.1%) had gastric adenocarcinoma, 136 (43.0%) oesophageal adenocarcinoma and 22 (6.9%) oesophageal squamous carcinoma. Staging laparoscopy revealed macroscopic metastases in 36 patients (22.6%) with gastric adenocarcinoma and 16 patients (11.8%) with oesophageal adenocarcinoma. Positive peritoneal cytology in the absence of macroscopic peritoneal metastases was identified in a further five patients with gastric adenocarcinoma and six patients with oesophageal adenocarcinoma. There was no significant difference in survival between patients with macroscopic peritoneal disease and those with positive peritoneal cytology (p=0.219). Conclusions Staging laparoscopy and peritoneal cytology should be performed routinely in the staging of distal oesophageal and gastric cancers where other investigations indicate resectability. Currently, in our opinion, patients with positive peritoneal cytology should not be treated with curative intent.
Diagnostic and Prognostic Value of BCL2 Rearrangement in 53 Patients With Follicular Lymphoma Presenting as Primary Skin Lesions
Authors: Pham-Ledard Anne , Cowppli-Bony Anne , Doussau Adélaïde , Prochazkova-Carlotti Martina , Laharanne Elodie , Jouary Thomas , Belaud-Rotureau Marc-Antoine , Vergier Béatrice , Merlio Jean-Philippe , Beylot-Barry Marie 
Published: February 2015

Abstract

Objectives:
To study the diagnostic value of BCL2 rearrangement in follicle center lymphoma (FCL) presenting as primary skin lesions, evaluate its prevalence and the prognostic value in primary cutaneous FCL (PCFCL), and assess prognostic factors in PCFCL.

Methods:
Fifty-three patients with a cutaneous presentation of FCL without a history of nodal lymphoma were selected retrospectively. Clinical and histologic data were collected together with staging and follow-up data. A fluorescence in situ hybridization (FISH) test for BCL2 split probes was performed on skin biopsy specimens.

Results:
Initial staging procedures identified 47 PCFCLs and six cases of secondary skin involvement of FCL (SSIFCL). FISH detected seven cases carrying a BCL2 rearrangement: four (8.5%) of 47 PCFCLs and three (50%) of six SSIFCLs. These seven cases coexpressed BCL2 and CD10. In PCFCL, cutaneous relapse rate was 42.6%. A small/medium centrocytic cell population was associated with a higher probability of skin relapse in univariate (P = .008) and multivariate (P = .028) analysis, and BCL2 rearrangement detection was associated with secondary extracutaneous spreading (P = .05).

Conclusions:
We observed that BCL2 rearrangement in PCFCL is rare, associated with initial positivity of staging (diagnostic value) or with secondary extracutaneous spreading (prognostic value). In selected cases with BCL2-CD10 coexpression, FISH testing could detect patients with poor outcome and require closer monitoring.
Effects of Levonorgestrel-Releasing Intrauterine System on Lymphangiogenesis of Adenomyosis
Authors: Cho SiHyun , Choi Young Sik , Yun Bo Hyon , Chon Seung Joo , Jung Yeon Soo , Kim Hye Yeon , Park Joo Hyun , Seo Seok Kyo , Kim Se Hoon , Lee Byung Seok 
Published: February 2015

Abstract

Objectives:
Lymphangiogenesis may be involved in the pathogenesis of adenomyosis. We investigated the lymphatic vessels of patients with adenomyosis, including those treated with levonorgestrel-releasing intrauterine system (LNG-IUS).

Methods:
Full-thickness uterine samples were obtained from patients who received hysterectomies. Twenty-one patients with adenomyosis and 17 patients with adenomyosis who were treated with LNG-IUS were included. Eighteen patients with cervical intraepithelial neoplasia served as controls. Immunohistochemical staining was performed with antibodies against podoplanin and lymphatic vessel endothelial hyaluronan receptor 1. The lymphovascular density (LVD) was analyzed in each sample by the “hot spot” method.

Results:
The LVDs were significantly higher in the endometrial and myometrial tissues of patients with adenomyosis compared with those of patients treated with the LNG-IUS or controls. No significant differences were noted between the LNG-IUS–treated group and controls. Evaluation of the LVDs according to the menstrual cycle showed that the differences in the endometrial tissues of the adenomyosis group and those of the LNG-IUS–treated group or the controls were more prominent during the secretory phase.

Conclusions:
Treatment with the LNG-IUS resulted in reduced lymphangiogenesis and LVD in the endometrial and myometrial tissues of patients with adenomyosis. Reduced lymphangiogenesis may be one mechanism by which the LNG-IUS reduces adenomyosis-related symptoms.
Significance of Serum 24,25-Dihydroxyvitamin D in the Assessment of Vitamin D Status: A Double-edged Sword?
Authors: Cashman Kevin D , Hayes Aoife , Galvin Karen , Merkel Joyce , Jones Glenville , Kaufmann Martin , Hoofnagle Andrew N , Carter Graham D , Durazo-Arvizu Ramon A , Sempos Christopher T 
Published: February 2015

AbstractBACKGROUND24,25-Dihydroxyvitamin D [24,25(OH)2D] in serum may be both a nuisance and nutritionally valuable.METHODSWe investigated the impact of 24,25(OH)2D3 on the performance of commercially available immunoassays for serum total 25-hydroxyvitamin D [25(OH)D] using (a) serum from a nationally representative sample of adults, (b) serum from a spiking experiment, and (c) data from the UK Vitamin D External Quality Assurance Scheme (DEQAS). We also investigated the utility of the serum ratio of 24,25(OH)2D3 to 25(OH)D as an index of inactivation and of response to vitamin D supplementation using randomized controlled trial (RCT) data. Measurement of 24,25(OH)2D in sera by a LC-MS/MS method allowed for an investigation of its impact on immunoassay-derived serum 25(OH)D values as well as its clinical utility. We report data from a nationally representative sample of adults, a recent vitamin D RCT in older adults, and DEQAS.RESULTS24,25(OH)2D3 contributed to the positive bias observed in some immunoassays relative to LC-MS/MS-derived estimates for total 25(OH)D. A spiking experiment showed that the degree of cross-reactivity with 24,25(OH)2D was high and may underpin this positive bias. Adjustment for 24,25(OH)2D3 concentration brought estimates closer to true values. Data from the vitamin D RCT showed that the ratio of 24,25(OH)2D3 to 25(OH)D was associated with serum 25(OH)D3 and with response of serum 25(OH)D to vitamin D supplementation.CONCLUSIONSOur findings highlight that the effect of 24,25(OH)2D3 in serum is a double-edged sword—an interferent for some immunoassays, yet potentially informative of nutritional status.
A Sense of Belonging: Walking with Thaer through migration, memories and space
Authors: O’Neill Maggie , Perivolaris John 
Published: February 2015

Abstract
‘A Sense of Belonging: Walking with Thaer through migration, memories and space’ introduces and provides a conceptual and affective context to the photographic essay by John Perivolaris ‘Walking with Thaer’. Undertaken as part of the ‘Transational Communities: Towards a Sense of Belonging’ project funded by the AHRC, Thaer led John on a walk from a space he called home in the city to a special place, mapping the spaces and places along the way that were important to him. The process of walking and talking opened up a relational and dialogic space where embodied knowledge, the relationship between the visual and other senses and memories were shared. The photographs and the narrative help us to see the importance of memories, that the past is ‘right here, in the midst of the present’ and that the stories told here also ‘leap forward’ and help to ‘map the future’. In looking at the minutiae, what is ordinarily overlooked, we can often reach a better understanding of the bigger picture – towards a radical democratic imaginary.
Towards efficient private distributed computation on unbounded input streams
Authors: Dolev Shlomi , Garay Juan , Gilboa Niv , Kolesnikov Vladimir , Yuditsky Yelena 
Published: February 2015

Abstract
In the problem of private “swarm” computing, n agents wish to securely and
distributively perform a computation on common inputs, in such a way
that even if the entire memory contents of some of them are exposed,
no information is revealed about the state of the computation.
Recently, Dolev, Garay, Gilboa and Kolesnikov
[Innov. Comput. Sci. (2011), 32–44]
considered this problem in the setting of information-theoretic security, showing how to perform such computations on input streams of unbounded length. However, the cost of their solution is exponential in the size of the finite state automaton (FSA) computing the function.
In this work we are interested in an efficient (i.e., polynomial time)
computation of the above model, at the expense of minimal
additional assumptions. Relying on the existence of one-way functions,
we show how to process unbounded inputs (polynomial in the security parameter)
at a cost linear in m, the number of FSA states. In
particular, our algorithms achieve the following:
In the case of (n,n)-reconstruction (i.e., in which all n
agents participate in the reconstruction of the distributed
computation) and at most n - 1 agents are corrupted, the time required to process each input symbol and the time complexity for reconstruction are

O
(
m
n
)

$O(mn)$

, while agent storage is

O
(
m
+
n
)

$O(m+n)$

.
In the case of

(
n
-
t
,
n
)

$(n-t,n)$

-reconstruction (where only

n
-
t

$n-t$

agents
take part in the reconstruction) and at most t agents are corrupted,
the agents' storage is

O
(

n
-
1

n
-
t

+
m
)

$O(\binom{n-1}{n-t}+m)$

, the time required to process each input symbol is

O
(
m

n
-
1

n
-
t

)

$O(m\binom{n-1}{n-t})$

and the time complexity of reconstruction is

O
(
m
t
)

$O(mt)$

.
We achieve the above through a carefully orchestrated use of pseudo-random generators and secret-sharing, and in particular a novel share
re-randomization technique which might be of independent interest.
Three ammonium salts of sulfathiazole: crystallography and anti-microbial assay
Authors: Akhmad Aznan Aina Mardia , Abdullah Zanariah , Khoo Chai-Hoon , Chen Bao-Jing , See Tian-Hong , Sim Jiun-Horng , Cheah Yoke-Kqueen , Seng Hoi-Ling , Tiekink Edward R.T. 
Published: February 2015

Abstract
The crystal and molecular structures of three ammonium salts derived from sulfathiazole are described. In each case, the anion is in the azanide form, features an intramolecular S←O interaction, and adopts a U-shape. The structures of two cations, [R(HOCH2CH2)NH2]+, namely for R = Me (1) and iPr (2), are unprecedented in the crystallographic literature. Extensive hydrogen bonding is observed in all crystal structures and leads to a two-dimensional array for 1, and three-dimensional architectures for each of 2 and 3 (R = CH2CH2OH). The salts exhibited anti-microbial activity against a range of Gram-positive and Gram-negative bacteria, and proved bactericidal toward Vibrio parahaemolyticus, but had no advantage over sulfathiazole itself.
Über die Beziehungen zwischen der chemischen Konstitution organischer Verbindungen und ihrem Rf-Wert in der Papierchromatographie II
Authors: Schauer H. K. , Bulirsch R. 
Published: February 2015

RM = log

als Meßwert, welcher dem vorgeschlagenen Verfahren zur Konstitutionsaufklärung zugrunde lag, hat sich nicht als allgemein brauchbar erwiesen. Auftretende Anomalien blieben zunächst unerklärt.
Es wurde daher versucht, die Theorie der Papierchromatographie auf eine breitere Grundlage zu stellen. Die so erhaltene Beziehung

erlaubt eine sinnvolle Deutung wesentlicher, in der Papierchromatographie beobachteter Abweichungen. Noch verbleibende Unschärfen sind z. T. experimentell oder materiell bedingt und nicht allgemein zu erfassen.
Durch Einführung physikalisch definierter Maßfunktionen für Rf von der Form log

für die das Symbol RN vorgeschlagen wird, kann in fast allen Fällen, in denen RM versagt, innerhalb gewisser Intervalle Linearität zwischen RN und den ganzzahligen Vielfachen der konstitutionellen Gruppen und Zustände organischer Verbindungen erzielt und damit eine Konstitutionsermittlung praktisch möglich gemacht werden.
Dies wird an einer Reihe von Beispielen belegt.
Untersuchungen sind im Gange, Rf durch eine bessere Meßgröße zu ersetzen
Hemmung der Tumorglykolyse durch 2-Methyl-1.4-naphthochinon
Authors: Tiedemann Heinz , Risse Hans-Jörg , Born Jochen 
Published: February 2015

Die Glykolyse (Substrat: Glucose) von Homogenaten des Ascites-Tumors der Maus und von intakten Tumorzellen wird durch 2-Methyl-1.4-naphthochinon in einer Konzentration von 4—5 · 10-5 Mol/l fast vollständig gehemmt. Unter anaeroben Bedingungen ist die Hemmung wesentlich geringer.
Bei Versuchen mit Homogenaten wurde die Bildung von Milchsäure aus Glucose stärker gehemmt als die Bildung von Milchsäure aus Glucose-6-phosphat oder Fructose-1.6-diphosphat.
Über den komplexen Bau der Membranen des Bindegewebes von Insekten
Authors: Richards A. Glenn , Schneider Dietrich 
Published: February 2015

The connective tissue sheeth around the nervous system of the cockroach and the silkworm moth is a heterogeneous and complicated structure. Microscopically one can detect small fibers, both longitudinal and circumferential, which are embedded in a seemingly non-fibrous matrix. Analysis of the optical properties with polarized light gave imbibition curves of unusual shape implying a relatively dense packing of micelles or crystallites. Tests showed recovery of length after stretching more than 100 per cent. This elasticity is accompanied by a strain birefringence that is both too great and too complicated to be explained as being due simply to improved alignment of the microscopically visible fibrils.
X.ray diffraction diagrams prepared by Dr. K. M. RUDALL show the presence of the 2,86 A line considered to be characteristic of collagens, but the intensity of this line implies a collagen concentration of only 10 — 20 per cent. Optical properties imply the presence of a lipid component. Staining and solubility properties are mostly similar to the collagenous proteins but do not agree completely with either collagen (stricto sensu), elastin or reticulin of vertebrates. The imbibition curves, the elasticity, and the strain birefringence are not consistent with the known properties of the collagegenous proteins—presumably these are due to the not yet identified protein or mucoprotein that makes up the bulk of the neural lamella and confers distinctive properties upon insectan connective tissue.
Untersuchungen über die Verteilung und Reaktionsfähigkeit von Sulfhydrylgruppen in der tierischen Zelle
Authors: Ernst Hanna , Hagen Ulrich 
Published: February 2015

Rattenleber-Homogenat wurde durch fraktioniertes Zentrifugieren in Mitochondrien, Mikrosomen, Überstehendes und Zellkerne, die ihrerseits in vier Proteinfraktionen zerlegt wurden, aufgeteilt. Die darin enthaltenen Sulfhydrylgruppen wurden durch ampèrometrische Hg-Titration bestimmt. Alkoholdenaturierung der Fraktionen erbrachte überall einen Anstieg der SH (maskierte SH-Gruppen), Denaturierung mit Harnstoffderivaten, Duponol und Enteiweißungsmitteln verminderten meist die meßbaren SH-Gruppen. Es konnte bewiesen werden, daß sich organische Säuren (SSS, TES, MPS) nicht zur Bestimmung von Nichtprotein-SH in tierischem Gewebe eignen.
Der SH-Gehalt der Leberzelle liegt zu 60% im Kern. Dort wurden im DNS-Protein keine, im RNS-Protein erhebliche Mengen von maskierten SH-Gruppen festgestellt. Diese Proteine enthalten fünfmal soviel Sulfhydrylgruppen pro Stickstoffeinheit wie die übrigen Zellfraktionen.
Genphysiologische Untersuchungen an der w-Mutante von Calliphora erythrocephala
Authors: Hanser Gisela 
Published: February 2015

Das w-Gen bewirkt eine weitgehende Hemmung der imaginalen Augenpigment-Synthese, die auch nach Transplantation der w-Augenanlagen in Larven der Wildform nicht aufgehoben wird. 3-Hydroxykynurenin ist bei der weißäugigen Mutante im Imaginalstadium nicht nachweisbar; seine Zuführung in einem früheren Entwicklungsstadium löst keine normale Augenpigment-Bildung aus. Dagegen hat Kälteeinwirkung während der sensiblen Phase der imaginalen Augenpigment-Entwicklung einen gesteigerten Farbstoffgehalt zur Folge.
Die weißäugigen Imagines besitzen in den normalerweise pigmentführenden Ommatidienzellen Eiweiß-Trägergranula.
In den Imaginalaugen von +-Calliphora liegt das Xanthommatin in verschiedenen Oxydationsstufen vor. Bei dem im Vergleich zur Wildform in Menge und Granulagröße stark reduzierten Farbstoff der w-Augen handelt es sich gleichfalls um Xanthommatin.
Ein Zuckerabbau zur Ermittlung der 14C-Verteilung
Authors: Weygand Friedrich , Fehr Kurt , Klebe Johann Friedrich 
Published: February 2015

Abstract
Es wird ein chemischer Abbau von 14C-markierter Glucose beschrieben, der die Einzelbestimmung der Aktivitäten aller C-Atome gestattet. Der Abbau kann auf andere Hexosen und auf Pentosen übertragen werden.
DNS - Aufnahme ruhender Bakterienzellen
Authors: Wacker Adolf , Pfahl Dörthe 
Published: February 2015

Abstract
An Desoxyribonucleinsäure verarmte Zellen von Lb. leichmannii 313 und Lb. acidophilus R26 nehmen ein Vielfaches ihres eigenen Desoxyribonucleinsäure-Gehaltes an fremder Desoxyribonucleinsäure auf.
Über den Stoffwechsel von Kulturhefe beim Wachstum
Authors: Kiesow Lutz 
Published: February 2015

Abstract
Bei Kulturhefe-Zellen, die in Würze wachsen, ist die aerobe Gärung zunächst eine Folge der gesteigerten anaeroben Gärung und wird im Verlauf des Wachstums durch die immer unwirksamere Pasteursche Reaktion noch weiter gesteigert.
Die Erhöhung der anaeroben Gärung ist durch Waschen zu beseitigen. Die allmählich einsetzende Schädigung der Pasteurschen Reaktion ist durch Waschen nicht zu beseitigen.
Zwischen der Hexokinase-Aktivität und der hohen anaeroben Gärung besteht eine Beziehung.
Über das lamellare Strukturproteid der Chloroplasten von Allium porrum
Authors: Menke Wilhelm , Jordan Evamaria 
Published: February 2015

Abstract
Die präparative Darstellung des lamellaren Strukturproteids der Chloroplasten wird beschrieben. Es ist in Wasser und Salzlösungen unlöslich und enthält 13,8% Stickstoff und 11% Kohlenhydrate. Das lamellare Strukturproteid ist zu 3/4 in einem warmen Phenol-Wasser-Gemisch unlöslich. Etwa 6% des Proteids lösen sich in Phenol. Die Kohlenhydrate werden bei der Phenolbehandlung nur zum Teil abgespalten. Die Aminosäure-Zusammensetzung des lamellaren Strukturproteids wird quantitativ bestimmt. Nach der Methode von Sanger wurden 9 verschiedene amino-endständige Reste festgestellt. Mittels Hydrazinolyse nach Akabori lassen sich 11 carboxyl-endständige Aminosäuren nachweisen. Das lamellare Strukturproteid wird als Komplex verschiedener Fermentproteine aufgefaßt.
Die Verwertung von Essigsäure durch Chlorella im Licht
Authors: Schlegel H. G. 
Published: February 2015

Abstract
Studies on the utilization of acetate-2-14C by Chlorella pyrenoidosa have shown that light brings about a preferential incorporation of acetate into the fatty acids of the cellular lipids. Approximately 50% of the labelled acetate-carbon added was found in the petroleumethersoluble fraction. The isotopepattern of glucose (from hydrolyzed starch) is in agreement with the function of the tricarboxylic acid-, glyoxylic acid-cycle respectively in Chlorella. The asymmetrical distribution of the labeled carbon (C 4, 5, 6 > C 1, 2, 3) in the glucose-molecule seems to indicate that there is a dilution of the dihydroxyacetone-moiety from a pool which may be fed by (trans) aldolase-reactions.
Der Einfluß von 2.4-Dinitrophenol auf den Phosphorstoffwechsel und die Bildung der metachromatischen Granula bei Mycobacterium phlei
Authors: Drews Gerhart 
Published: February 2015

Abstract
2.4-Dinitrophenol hemmt die Bildung der metachromatischen, polyphosphathaltigen Granula und die Synthese des „säureunlöslichen Phosphates“ von Mycobacterium phlei merklich erst oberhalb 8·10-4 mol. Entgegen der bei normaler, durch Dinitrophenol bedingter Entkopplung beobachteten Stimulierung der Atmung wird diese ebenfalls gehemmt.