bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing climate variability and its correlation with regional air pollution in Chhattisgarh, India utilizing Google Earth Engine (GEE)
Authors: SINGH LEELAMBAR , MUNDETIA NITIKA , TRIPATHI RAVINDRA NATH 
Published: July 2024

Abstract

This study investigates the spatiotemporal dynamics of key atmospheric pollutants and environmental variables in Chhattisgarh using satellite remote sensing data from 2019 to 2023. The dataset includes parameters such as Land Surface Temperature (LST), Normalized Difference Vegetation Index (NDVI), rainfall, and concentrations of carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), methane (CH4), ozone (O3), and UV aerosol index (AI) with the help of Google Earth Engine (GEE) algorithms. Analysis revealed distinct seasonal patterns, with the highest rainfall recorded during the monsoon season, predominantly in the southern region, and elevated LST values observed in the central region during pre-monsoon months. Furthermore, CO concentrations peaked (0.057 mol/m2) during the pre-monsoon season, particularly in industrial zones, while NO2 levels were highest in the central region across all seasons. SO2 concentrations exhibited spatial variability, with peaks (0.00204 mol/m2) in the post-monsoon period, primarily attributed to industrial activities. CH4 concentrations were higher during pre-monsoon and post-monsoon seasons, with anomalies observed in 2023. O3 levels showed a seasonal variation, with higher (0.1289 mol/m2) concentrations during pre-monsoon months, especially in the northern region. The UV aerosol index was highest during the monsoon season, attributed to increased moisture and biomass burning. Correlation analysis revealed associations between pollutants and environmental variables, indicating potential sources and interactions. These findings contribute to understanding regional air quality dynamics and informing targeted mitigation strategies for sustainable environmental management in Chhattisgarh.
The DUF1127 containing protein and ProQ had opposite effects on biofilm formation in Vibrio alginolyticus
Authors: Feng Ruonan , Chen Ying , Chen Tongxian , Hu Zhong , Peng Tao 
Published: July 2024

Abstract

RNA binding protein plays an important role in gene regulation on post transcription level. In this study, functions of the DUF1127containing protein and ProQ, which were considered as RNA binding proteins, were revealed in Vibrio alginolyticus. The results showed that an increase ability of biofilm formation was observed by DUF1127 deletion, while ProQ deletion resulted in a less amount of biofilm detected. Moreover, the extracellular proteinase secreted was significantly reduced in DUF1127 deletion strain and ProQ can help the cell to defense oxidative stress. The data of RNA-seq showed the expressions of genes involved in the secretion of extracellular proteases were significantly downregulated and also the genes related to the synthesis of biofilm, such as rbsB, alsS, exhibited differential expression in DUF1127 deletion strain. The expressions of genes involved in biofilm synthesis (flgC, flgE), virulence (betB, hutG), and oxidative stress were affected by ProQ. Moreover, various regulators, such as LysR, BetI, whose mRNA level were affected by the DUF1127 protein and ProQ. Overall, our study showed that the DUF1127 protein and ProQ had important functions in biofilm formation in Vibrio alginolyticus.
The effect of tacrolimus combined with mycophenolate mofetil or cyclophosphamide on renal response in systemic lupus erythematosus patients
Authors: Sun Siqin , Zhang Xueyi , Guo Qingqing , Tang Xiaojun , Shen Wei , Liang Jun , Yao Genhong , Geng Linyu , Ding Shuai , Chen Hongwei , Wang Hong , Hua Bingzhu , Zhang Huayong , Feng Xuebing , Jin Ziyi , Sun Lingyun 
Published: July 2024

Abstract

Objective
This study aimed to determine the therapeutic effect of tacrolimus (TAC) and its combination with mycophenolate mofetil (MMF) or cyclophosphamide (CYC) on the complete response (CR) in patients with systemic lupus erythematosus (SLE).
Methods
A retrospective cohort study based on medical data was conducted among SLE patients taking at least one of TAC, MMF and CYC during 2010–2021. Odds ratio (OR) and 95% confidence interval (CI) were calculated and multiplicative interactions were estimated using logistic regression models.
Results
Among 793 SLE patients, 27.9% (221 cases) patients achieved CR after at least 3 months. TAC use was positively associated with CR with adjusted OR (95% CI) of 2.82(1.89, 4.22) in overall, as well as in subgroups of SLE patients with SLEDAI score > 12, moderate or severe urinary protein and comorbidities. The dose-response effect on CR was further observed at the dose of TAC more than 4 mg/d and more than 180 days, with adjusted OR (95% CI) of 5.65(2.35, 13.55), and 3.60(2.02, 6.41) respectively. Moreover, the combined effect of TAC with MMF or CYC was better than monotherapy with the significant multiplicative interaction, with adjusted OR (95% CI) of 2.43(1.20,4.92) and 3.14(1.49,6.64), respectively, and similar results were also observed for the combination of different doses of TAC with MMF or CYC.
Conclusion
TAC can effectively alleviate the condition of patients with SLE and may interact with MMF or CYC, suggesting that the combination therapy of TAC with MMF or CYC may produce greater benefits for patients with SLE.
Trial registration:
This is a purely observational study that does not require registration.
Histopathological assessment to detect colorectal ovarian micrometastasis following prophylactic salpingo-oophorectomy in postmenopausal patients
Authors: Zon Jasper van , Heijmans Margot , Bosch Steven , Bloemen Johanne , Leclercq Wouter , Roumen Rudi 
Published: July 2024

Abstract

Purpose
Colorectal cancer (CRC) is one of the most prevalent malignancies and often leads to metastatic disease. Ovarian metastasis occurs in approximately 4% of all female CRC patients. Metastatic disease recurrence after intentional curative resection of primary colorectal tumour could be explained by the presence of micrometastases. The present study aims to investigate the prevalence of CRC (micro)metastases in tubo-ovarian tissue following prophylactic salpingo-oophorectomy (PSO) in postmenopausal patients.
Methods
Analyses of both adnexa of postmenopausal CRC patients who underwent primary tumour resection and concurrent PSO were conducted retrospectively. Tissue blocks with Formalin Fixed Paraffin Embedded ovarian tissue were sectioned at 5 levels and both routine histopathological and additional immunohistochemical staining for CK20 and CDx2 were performed. The primary outcome measure was incidence of CRC micrometastases (%).
Results
Ovaries of 100 consecutive CRC patients who underwent surgery at two Dutch teaching hospitals were analysed [age 72.7 ± 7.6 years, pT0-2 (43%) and pN0 (65%)]. Overall, ovarian malignancies were found in 4% of patients. Immunohistochemical analysis revealed no additional CRC (micro)metastases.
Conclusion
Additional immunohistochemical assessment did not reveal CRC ovarian (micro)metastases in an unselected patient cohort. The absence of micrometastases could be attributed to patient selection criteria and/or sampling error. Future research should focus on identifying a subgroup at high risk of developing ovarian metastasis and on improvement of diagnostic and therapeutic strategies.
Single Organic Electrochemical Neuron Capable of Anticoincidence Detection
Authors: Fabiano Simone , Harikesh Padinhare Cholakkal , Wu Han-Yan , Yang Chi-Yuan , Tu Deyu 
Published: July 2024

Abstract

Emulating complex neural computations like solving linearly inseparable data within single artificial neurons has remained an elusive goal in neuromorphic engineering. Here, we report an unprecedented dendritic organic electrochemical neuron (d-OECN) capable of achieving anticoincidence detection by classifying the exclusive-OR (XOR) problem - a quintessential linearly inseparable task - within an individual neuron. Inspired by human cortical neurons that perform XOR through dendritic calcium spikes, the d-OECN leverages ion-tunable anti-ambipolarity in mixed ionic-electronic conducting polymers to mimic voltage-gated dendritic calcium dynamics. Integrating this dendritic component with a tunable spiking neuron soma, the d-OECN successfully solves XOR via its inherent nonlinear activation profile. Crucially, the decision boundaries of the classification are ionically and electrically tunable. This d-OECN, replicating sophisticated biological intelligence, constitutes a major neuromorphic advance paving the way for next-generation bioelectronics and robotics requiring complex neural computation.
Breast tumor segmentation in ultrasound using distance-adapted fuzzy connectedness, convolutional neural network, and active contour
Authors: Biesok Marta , Juszczyk Jan , Badura Paweł 
Published: July 2024

Abstract

This study addresses computer-aided breast cancer diagnosis through a hybrid framework for breast tumor segmentation in ultrasound images. The core of the three-stage method is based on the autoencoder convolutional neural network. In the first stage, we prepare a hybrid pseudo-color image through multiple instances of fuzzy connectedness analysis with a novel distance-adapted fuzzy affinity. After the hybrid image is processed by the deep network, we adjust the segmentation outcome with the Chan-Vese active contour model. We find the idea of incorporating fuzzy connectedness into the input data preparation for deep-learning image analysis our main contribution to the study. The method is trained and validated using a combined dataset of 993 breast ultrasound images from three public collections. The experiments address essential settings and hyperparameters of the method, e.g., the network architecture, input image size, and active contour setup. The tumor segmentation reaches a median Dice index of 0.86 (mean at 0.79) over the combined database. We refer our results to the most recent state-of-the-art using the same datasets, finding our model comparable in segmentation performance.
OSI Network Layers Based Secured Data Sharins in Cloud Computing Using STXORSK-QC and Dhdecct-MAC
Authors: TIWARI CHANDRA SHEKHAR , JHA VIJAY KUMAR 
Published: July 2024

Abstract

Cloud computing, which acts as a service tool to internet users, has numerous data sources. The data from users should be stored and shared securely. Data security regarding Open System Interconnection (OSI) network layers was not concentrated by any of the existing works. Hence, a secured data sharing in the OSI model is proposed in this paper. Primarily, the data owner registers in the Application Layer and logs in to access the cloud. Then, with the help of preprocessing, optimal feature selection using the Bernoulli Distribution Lyrebird Optimization Algorithm (BD-LOA), and classification using Beltrami-coefficient Rectified Linear Unit-Long Short Term Memory (BR-LSTM), the Uniform Resource Locator (URL) link is verified in the Presentation Layer. Now, the data is uploaded to the cloud via the legitimate site. Here, using Security Token XOR Session Key Quantum Cryptography (STXORSK-QC), the data is secured in the Authorization Layer. Then, in the Network Layer, the IP address of the user is spoofed by the Knuth shuffle technique. Now, the data is uploaded to the Physical Layer using 2’s Complement Grøstl Hashing Algorithm (2CGHA) after balancing the loads of multiple requests using BD-LOA in the Transport Layer. In the meantime, by using the Diffie Hellman Digit Folding Caesar Cipher Text-Message Authentication Code (DHDFCCT-MAC) algorithm, the user verification is done. The data to be downloaded in the Data Link Layer is checked by the verified user. The user downloads the data if it is not attacked. Therefore, the proposed system uploaded the data with a 98.03% security level and classified the data attack with 99.15% accuracy, thus showing superior performance than the existing works.
A Multilevel Analysis of Factors Associated with Minimum Dietary Diversity Among Children Aged 6–23 Months in Lesotho: A Lesotho Multiple Cluster Study Of 2018
Authors: Leseba Nthatisi , Vermaak Kerry , Makatjane Tiisetso 
Published: July 2024

Abstract

Background
Adequately diversified nutrition during infancy and childhood is fundamental in the development and optimal growth of the child. Globally, complex, and intertwined determinants of minimum dietary diversity (MDD) have been explored at individual, household, and community level but, not in Lesotho. The objective of the study was to investigate the determinants of minimum dietary diversity at the individual, household, and community level.
Methods
We conducted a multilevel logistic regression using data from the Lesotho Multiple Cluster Indicator Study of 2018. The variables used in the analysis were informed by the UNICEF conceptual framework on maternal and malnutrition. MDD was defined as receiving 4 or more different food groups in the previous 24 hours.
Results
Only 40.5% (CI: 36.7, 44.5) of the children aged 6–23 months received MDD in 2018. At an immediate individual level: child age and weight at birth were determinants of MDD. At the underlying or household level: household wealth, maternal education, and maternal residential status were determinants of MDD. Community food security, the proportion of women and men in the community who have completed their education, community poverty, and the proportion of women in the community with media exposure were determinants of MDD at a basic or community level.
Conclusion
There is evidence of variability in the data in relation to MDD at community level. It also shows that community knowledge and information sharing is important in improving MDD in Lesotho. Therefore, strategies and programs to improve MDD nationwide should be done at community level.
Research on Technological Hotspots and Trends of Digitalization of Standard Based on Keyword Co-occurrence Atlas
Authors: Niu Nana , Liu Xize , Wang Yiyi , Zhang Bingyan , Li Jingsheng 
Published: July 2024

Abstract

With the continuous advancement of the process of industrial digitalization, standards, as one of the elements of industrial development, will be closely intertwined with digitalization, have a profound impact on technology, industry and society, and jointly promote the development of sustainable ecology. Based on the Technology Breakdown Theory and CiteSpace tools, this study collected the literature data of journal papers and standards related to digitalization of standard published from 2017 to 2021, and made a keyword co-occurrence atlas analysis on five key technical topics related to digitalization of standard, semantic web, digital model, open source and virtual reality enhancement. It identifies new technological hotspots in standard content generation, standardization modes, and applications of standards. New trends in evolution of the standard itself, the development of the standardization ecosystem, and governance in the context of the new technologies are summarized, including structuring, semanticization and machine language representation of the content; open source technologies make standards more open, shareable, and intelligent; digital technologies brings new governance challenges in the field of standardization. This study systematically compiles and prospects the technological hotspots and trends of digitalization of standard, and supports the formation of related technical routes and risk response plans by data analysis.
Transthoracic Elastography in Differentiation of Lung Lesions in Dogs
Authors: Lima Bruna Bressianini , Carneiro Rafael Kretzer , Miranda Brenda Santos Pompeu , Gasser Beatriz , Aires Luiz Paulo Nogueira , Uscategui Ricardo Andrés Ramirez , Lacreta Antônio Carlos Cunha , Doiche Danuta Pulz , Feliciano Marcus Antônio Rossi 
Published: July 2024

Abstract

The objective of this study was to evaluate the applicability of ARFI elastography in 36 prospective cases in differentiating parenchymal lung abnormalities in dogs: consolidations, atelectasis and neoplasms, the latter being subdivided into nodules and masses; and correlates the data obtained by the technique with B-mode ultrasound parameters, cytology results, histopathology and information from the analysis of pleural effusions when present, in addition to clinical data, indicating cut-off values in dogs. Characteristics of lung lesions were evaluated using radiography as a screening test to locate the lesions and B-mode ultrasound. Subsequently, elastographic characteristics (qualitative and quantitative) were evaluated. B-mode ultrasound assessments and qualitative elastography were not statistically demonstrated in the parameters studied to differentiate between malignant and benign lesions (p > 0.05); while in the quantitative elastographic evaluation, less atelectatic lesions (1.48 m/s) were affected when compared to nodules (2.84 m/s), consolidations (2.94 m/s) and masses (3.12 m/s), in ascending order of complaint, demonstrating statistical significance (p = 0.023), even though a diagnostic cut-off value was not obtained. It is concluded that ARFI can contribute to the differentiation of lung lesions, complementing clinical data in the evaluation of dogs.
Remote screening protocol for functioning and contextual factors (e-Followkids) in Brazilian children with biological risk in the first 2 years: a longitudinal prospective study
Authors: de Abreu Raissa Wanderley Ferraz , Lima Camila Resende Gâmbaro , Santos Adriana Neves dos , Rocha Nelci Adriana Cicuto Ferreira 
Published: July 2024

Abstract

Background
Children with biological risk may experience developmental delays, even in the absence of brain injury. Identifying warning signs and knowledge of contextual factors are vital to favor intervention. Telehealth can aid in screening by providing access for populations that face physical and social barriers. As such, the aim of this study was to describe the e-Followkids screening protocol and how its feasibility will be assessed.
Methods
A multicentric longitudinal prospective study with 50 caregivers of children born with some form of biological risk: preterm, low birth weight or perinatal complications. Screening will be conducted remotely at 12, 18 and 24 months old, using internationally recognized instruments with valid psychometric properties. Functional skills will be measured via the Pediatric Evaluation of Disability Inventory Computer Adaptive Test and participation by Young Children's Participation and Environment Measure. Contextual factors will be analyzed using the Child’s Context questionnaire, the environment portion of each section of the YC-PEM, Social Support Scale, the physical dimension of the Affordances in the Home Environment for Motor Development scale, sociodemographic data, and the Survey of Well-being of Young Children. The data will be collected by filling out forms, telephone interviews or video calls.
Discussion
The e-Followkids protocol could contribute to identifying possible signs of limitations and guiding referrals to specialized intervention.
A clinical trial comparing the occlusal parameters and wear of artificial teeth between lingualized and anatomical occlusal complete dentures
Authors: wang zhiqiang , su yan , wang jianmin , liu yang , xing wenzhong 
Published: July 2024

Abstract

Object:
The purpose of this study was to compare the occlusal parameters and the wear of artificial teeth between lingualized and anatomical occlusal complete dentures.
Methods
Edentulous patients who met the inclusion criteria were divided into three groups, and each patient made a complete denture. The Excellence IPN (IPN) group and Surpass G group were lingualized occlusal complete dentures, and Endura group was anatomical occlusal complete dentures. The occlusal contact area (OCA) and occlusal contact number (OCN) of the mandibular dentures was measured by silicone rubber translucency method, and the bite force was measured with Dental Prescale II at the 2-week, 3-month, and 12-month follow-up visits. The complete dentures were scanned at the 2-week and 12-month follow-up visits, and the wear of the maxillary and mandibular posterior teeth was assessed with software (Geomagic Qualify 2013; Raindrop). The data were analyzed by SPSS software.
Results
The results of One-way ANVOA showed that the OCA of the Endura group were significantly larger than the IPN and Surpass G groups at the 2-week follow-up visits, while the OCA of the IPN group were significantly larger than the Endura and Surpass G groups at the 3-month and 12-month follow-up visits (P < 0.05). The OCN of the three groups were significantly different at the 2-week, 3-month, and 12-month follow-up visits (P < 0.05). The bite force of IPN and Surpass G group were significantly lower than that of Endura group at the 2-week, 3-month, and 12-month follow-up visits (P < 0.05). The wear of IPN and Surpass G artificial teeth was significantly greater than Endura at the 12-month follow-up visits (P < 0.05)
Conclusions
The occlusal contact area increased as the complete dentures were used for longer periods of time. Compared with anatomical occlusion, lingualized occlusion was able to reduce the bite force. Wear varied among the three types of artificial teeth. (The Chinese Clinical Trial Registry (No. ChiCTR2300073420))
Association of Physical Activity with Chronic Diseases: A Cross-sectional Study of 18500 Middle-aged and Elderly Chinese
Authors: Huang Yongyu , Lu Zuosheng 
Published: July 2024

Abstract

Background
Regular physical activity is beneficial for both physical and mental health. However, studies on physical activity levels among middle-aged and elderly individuals in China are relatively scarce, and the health benefits of different activity levels remain unclear.
Objective
Using cross-sectional data from the 2020 China Health and Retirement Longitudinal Study (CHARLS), this study describes the prevalence of chronic diseases and examines their association with physical activity (PA).
Methods
Participants self-reported the presence of fifteen chronic health conditions: Hypertension, Dyslipidemia, Diabetes, Cancer or Malignant tumor, Chronic lung diseases, Liver disease, Heart attack, Stroke, Kidney disease, Stomach or other Digestive diseases, Emotional, Nervous, or Psychiatric problems, Memory-related diseases (such as dementia, brain atrophy), Parkinson’s disease, Arthritis or Rheumatism, and Asthma. Total physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). Multivariate logistic regression was used to estimate the association between chronic diseases and PA.
Results
In China, more than a quarter of middle-aged and elderly individuals do not meet physical activity guidelines, with only about a third achieving high activity levels. Compared to those with low PA, individuals with moderate PA had a reduced risk of 4 chronic diseases (Stroke, Emotional and Mental problems, Memory-related diseases, Asthma), while those with high PA had a reduced risk of 10 chronic diseases (Hypertension, Dyslipidemia, Diabetes, Cancer, Heart attack, Stroke, Emotional, Nervous, or Psychiatric problems, Memory-related diseases such as dementia and brain atrophy, Parkinson’s disease, Asthma).
Conclusion
Higher physical activity levels are associated with lower risks of chronic diseases. Governments and organizations should encourage individuals to achieve higher activity levels (> 3000 MET-min/week), not merely meet physical activity guidelines (≥ 600 MET-min/week).