bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proliferation Patterns Reflect Architectural Dedifferentiation: A Study of Nodular Basal Cell Carcinoma
Authors: Cabral Ailton , Haaften Caroline van , Boon Mathilde E. 
Published: July 2014

AbstractThe distribution of proliferating cells in basal cell carcinoma (BCC) may be related to lesion type and architecture. Single proliferation indexes may not be representative. We aimed to establish the distribution of cell proliferation in BCC as related to architecture. We studied an unselected, consecutive series of 45 resection specimens of nodular BCC from patients in the age range of 25–95 years using MIB‐1 staining and systematically reviewed the cases. These lesions included nodular (n=32) and non‐nodular (n=9) BCC. Within the nodular BCC, two patterns were recognised, not related to age or gender. In small nodular patterns with well developed peripheral palisading and central parallel streaming of small, elongated nuclei, proliferation is limited to the basal palisading cells in a clustered distribution. In large nodular patterns, proliferation is absent at the basal membrane (BM) and distributed in single random cells throughout the lesion. Both patterns preclude accurate quantitation. Many lesions contained both patterns in a side‐by‐side, unmixed manner. These pattern differences suggest a loss of differentiation in nodular BCC. Perhaps a single mutation results in the loss of BM associated cell architecture and proliferation control related to tumor‐stroma interactions. As a result, the lesion reverts to a low frequency, non‐regulated proliferation, diffusely distributed throughout the lesion. The two patterns may exist side‐by‐side in a single lesion, further supporting the concept of polyclonality. This hypothesis explains perilesional clefting and previously reported variations in intra‐lesional laminin synthesis. Based on our findings, representation of tumor cell proliferation activity by a single value is not justified. Nodular BCC exists in one of two dedifferentiation‐mutation‐determined patterns of cell proliferation; many lesions clearly demonstrate bi‐clonality.
Hereditary Punctate Palmoplantar Keratoderma (PPK) (Brauer‐Buschke‐Fischer Syndrome)
Authors: Gupta Ritika , Mehta Shilpa , Pandhi Deepika , Singal Archana 
Published: July 2014

AbstractWe describe the first case of a sixty‐five‐year‐old male field worker from India, having lesions of hereditary punctate palmoplantar keratoderma with an autosomally dominant pattern of inheritance. Associations included nail abnormalities in the form of longitudinal ridging, onychorrhexis, onychoschizia, trachyonychia and notching, which has been reported only on one previous occasion. The article also presents a brief review of the literature.
A Case of Herpetiform Pemphigus with Anti‐Desmoglein 3 IgG Autoantibodies
Authors: Isogai Rieko , Kawada Akira , Aragane Yoshinori , Amagai Masayuki , Tezuka Tadashi 
Published: July 2014

AbstractHerpetiform pemphigus (HP) is a rare variant of pemphigus characterized by a unique clinical phenotype of erythematous or urticarial plaques and vesicles that present in a herpetiform arrangement. Most HP cases have circulating anti‐desmoglein 1 (Dsg1) IgG autoantibodies, but some HP cases have anti‐desmoglein 3 (Dsg3) IgG. A 92‐year‐old Japanese woman presented with severely pruritic annular erythema and vesicles in a herpetiform arrangement on the trunk. No oral mucosal lesions were present. Histopathologically, these vesicles showed eosinophilic spongiosis as well as suprabasilar acantholysis. Direct immunofluorescence showed in vivo IgG deposition on keratinocyte cell surfaces, and indirect immunofluorescence showed circulating IgG autoantibodies against keratinocyte cell surfaces at a titer of 1:30. Enzyme‐linked immunosorbent assay using recombinant Dsg1 and Dsg3 revealed the presence of anti‐Dsg3 IgG but no anti‐Dsg1 IgG autoantibodies. The lack of oral mucosal involvement and the unique clinical features favored the diagnosis of HP. It remains to be clarified why the anti‐Dsg3 IgG autoantibodies in this patient induced this unique features of HP, rather than the mucosal dominant type of pemphigus vulgaris.
Variegate Porphyria
Authors: Sandhu Kamaldeep , Kumar Bhushan 
Published: July 2014

AbstractVariegate porphyria is a rare, hereditary form of hepatic porphyria characterized by acute systemic symptoms as in acute intermittent porphyria in addition to cutaneous symptoms simulating porphyria cutanea tarda. We describe a 22‐year‐old female from India who first presented to the emergency department with acute symptoms and was later confirmed to have variegate porphyria.
Evaluation of Oxidative Stress in Cutaneous Leishmaniasis
Authors: Ozbilge Hatice , Aksoy Nurten , Kilic Eser , Saraymen Recep , Yazar Süleyman , Vural Huseyin 
Published: July 2014

AbstractOxidative stress occurs when there is excessive free‐radical production or a low antioxidant level. The role of free radicals in the pathogenesis and in the progression of many diseases has often been discussed, but it has not been widely investigated in leishmaniasis. However, measurement of oxidants and antioxidants in the serum seems to be of great value. In this study, we aimed to determine lipid peroxidation levels as markers of oxidative stress in the serum of patients suffering from cutaneous leishmaniasis, which is a common health problem in our region of Southern Anatolia, Turkey. Forty patients aged between 5–50 years and forty controls aged between 5–50 years were included in the study. The LPO levels of the patients with active cutaneous leishmaniasis were significantly higher (p<0.001) than those of healthy controls. As a result, it is possible to conclude that patients with cutaneous leishmaniasis are affected by oxidative stress, which may contribute to the progression of the disease.
Oral Fluconazole in the Treatment of Tinea Versicolor
Authors: Karakaş Mehmet , Durdu Murat , Memişoğlu Hamdi R. 
Published: July 2014

AbstractThis study was designed to assess the efficacy, tolerability, and safety of oral fluconazole given at 300 mg once weekly for two weeks in the treatment of tinea versicolor. Enrolled into the study were 44 subjects with tinea versicolor, provisionally confirmed by the detection of fungal hyphae in KOH wet mounts and Wood's lamp examination. Four subjects were classified as dropouts because no information was obtained from them after the baseline visit. Subjects were treated for two weeks orally with fluconazole 300 mg weekly and followed at the 1st, 2nd, 4th and 12th weeks of treatment. The study included 40 subjects (26 males and 14 females, mean age 29 years, range 19–48 years). At the week 4 visit, 30 (75%) patients showed a complete cure and 31 (77.5%) patients showed mycologic cure. Ten (25%) patients had no significant response to therapy. At the final follow‐up visit (week 12), none of the patients showing complete or mycologic cures exhibited a recurrence. No adverse effects were observed in any of the patients treated. We believe that, due to the low incidence of side effects, shorter treatment duration, and increased adaptation of the patients, fluconazole can be used in the treatment of tinea versicolor with confidence.
Efficacy of Terbinafine 1% Cream on Seborrhoeic Dermatitis
Authors: Gündüz Kamer , Inanir Isil , Sacar Handan 
Published: July 2014

AbstractSeborrhoeic dermatitis (SD) is a common chronic inflammatory skin disease. Although the exact pathogenesis of SD is unknown, Malassezia yeasts as well as genetic and environmental factors have been implicated. The aim of this study was to evaluate the efficacy of terbinafine 1% cream on SD lesions with face localisation. Thirty‐five patients with SD were included in the study. Patients applied terbinafine 1% cream twice daily for four weeks. The severity of the signs (erythema, scaling, infiltration) was assessed using a 4‐point score (0=absent, 1=mild, 2=moderate, and 3=intense) at baseline and at the 2nd and 4th weeks of the therapy. Also, self‐assessment was done by the patients on a 100 mm visual analogue score (VAS) at each visit. Complete remission was observed in 10 (32.3%) patients at the end of the therapy. Statistically significant reductions in the scores of all parameters were observed at both the 2nd and 4th weeks of the therapy. Patients' self assessments in the 2nd and 4th weeks were similarly better than at the baseline.
Membranous Lipodystrophy‐Like Changes in Two Cases of Traumatic Lipogranuloma Caused by Safety Belts
Authors: Lee Jin Wook , Bak Hana , Park In Ho , Choi Eung Ho , Ahn Sung Ku 
Published: July 2014

AbstractA few cases of subcutaneous nodules with the histological findings of membranous lipodystrophy‐like changes have been reported in the literature. However, reports of membranous lipodystrophy‐like changes caused by trauma are exceedingly rare. We report two cases of traumatic lipogranuloma that had linear and multiple lesions showing membranous lipodystrophy‐like changes and were induced by safety belt trauma after a car accident. These patients showed peculiar changes in their subcutaneous fat and had linear patterned, multiple, nodular lesions with membranous lipodystrophy‐like changes caused by trauma.
Double‐Blind, Crossover Comparison of Olopatadine and Cetirizine versus Placebo: Suppressive Effects on Skin Response to Histamine Iontophoresis
Authors: Morita Eishin , Matsuo Hiroaki , Zhang Yan 
Published: July 2014

AbstractOlopathadine, a newly developed histamine H1‐receptor antagonist, was compared with cetirizine in its suppressive effects on histamine‐induced wheal and flare reaction using an iontophoresis technique in a double‐blind, crossover, placebo‐controlled fashion. As a result, olopathadine was found to have effects comparable to cetirizine. This finding may predict the efficacy of this new H1‐antagonist in treating pruritic skin diseases.
Peripheral T‐Cell Lymphoma with Secondary Epithelioid Granulomatous Cutaneous Involvement: A Clinicopathologic Study of Four Cases
Authors: Pujol Ramon M. , Gallardo Fernando , Servitje Octavio , Martí Rosa M. , Bordes Ramon , García‐Muret M. Pilar , Estrach M. Teresa , Nomdedeu Josep F. 
Published: July 2014

AbstractEpithelioid granuloma formation has rarely been observed in specific cutaneous lesions from T‐cell lymphomas other than those of mycosis fungoides/Sézary syndrome (MF/SS). Three patients diagnosed with nodal and/or extranodal (tonsillar) non‐Hodgkin's peripheral T‐cell lymphoma (PTCL) and one patient with angioimmunoblastic T‐cell lymphoma (AILD), developed specific cutaneous involvement showing prominent epithelioid cell and/or granulomatous inflammation. The original diagnostic lesions had no granulomatous features. In addition to a specific lymphomatous infiltrate, prominent dermal and/or subcutaneous granulomatous infiltrates were observed. Sarcoid‐like granulomas were observed in two patients (one of them presented a granuloma annulare‐like pattern in early lesions), granulomatous panniculitis was noted in one patient and in one patient with AILD, masses of epithelioid cells were noted. The clinicopathological features of cutaneous involvement by PTCL showing a florid epithelioid and/or granulomatous cell reaction are reviewed. Various histopathological patterns can be observed. The diagnostic difficulties of these cases are stressed.
Trichostasis Spinulosa Arising within Syringoma
Authors: Chun Seung Hyun , Bak Hana , Park Chang Ook , Choi Eung Ho , Ahn Sung Ku 
Published: July 2014

AbstractA forty‐eight‐year‐old man presented with multiple pinhead to rice‐sized papules on the face. Histopathologic examination showed a typical syringoma and dilated hair follicles containing several vellus hairs in the middle of a fibrotic stroma. We discuss the possible pathomechanism between these two conditions in the same lesion.
Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System
Authors: Ungerstedt U. 
Published: July 2014

AbstractThe effect of L‐DOPA and the dopamine (DA) receptor stimulating drug apomorphine was studied in rats after unilateral degeneration of the nigrostriatal DA system by intracerebral injection of 6‐hydroxydopamine. Both apomorphine and L‐DOPA induced a strong rotational behaviour which was registered in a specially designed “rotameter”. The direction of the rotation indicated that the denervated striatum was more sensitive to DA receptor stimulating drugs than the innervated striatum. This supersensitivity probably corresponded to the decentralisation type of supersensitivity in the peripheral nervous system although it developed faster. The action of L‐DOPA was inhibited by pretreatment with the DOPA‐decarboxylase inhibitor Ro4–4602 which indicated that L‐DOPA must be converted to DA in order to stimulate the supersensitive postsynaptic cells. Pretreatment with a single dose of reserpine also induced supersentitivity to apomorphine which reached its maximum on the 3rd day and then decreased on the 4th day. Postsynaptic supersensitivity after degeneration of the nigro‐striatal DA system is probably an important reason for the effectiveness of the L‐DOPA therapy against Parkinson's disease.
Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System
Authors: Ungerstedt U. 
Published: July 2014

AbstractThe functional role of the nigro‐striatal dopamine (DA) system has been investigated on the basis of a recent detailed mapping of its path and a new method of lesioning the catecholamine systems selectively by intracerebral injection of 6‐hydroxydopamine (6‐OH‐DA). The investigation was especially focused on the symptoms of adipsia, aphagia, hypokinesia and catalepsia after lateral hypothalamic lesions as such lesions may interrupt the ascending DA axons. Electrocoagulations or 6‐OH‐DA lesions were performed bilaterally at several sites along the DA pathway and the behavioural effects were evaluated in relation to the histochemically detected lesion of the DA pathway. It was concluded that bilateral complete degeneration of the nigro‐striatal DA pathway produces severe, long lasting adipsia and aphagia, hypoactivity, difficulties to initiate activity and loss of exploratory behaviour and curiosity. Experiments with DA receptor stimulating and blocking drugs supported the lesion results. Catalepsia and somnolence were attributed to the interruption of other pathways. The results suggest an important role for the nigro‐striatal DA system and the striatum in the control of behaviour. A number of symptoms earlier related to the hypothalamus may in fact be due to disturbance of the nigro‐striatal DA system.
WaDE: An Interoperable Data Exchange Network for Sharing Water Planning and Use Data
Authors: Larsen Sara G. , Young Dwane 
Published: July 2014

AbstractThe Water Data Exchange (WaDE) is a project initiated by the member states of the Western States Water Council (WSWC), in cooperation with the Western Governors’ Association (WGA), to assist state water agencies when answering local, regional, and national water availability questions. WaDE provides requested information more easily, sustainably, and cost‐effectively, by streamlining the publication of water planning, use, and allocation data for access by planners, policy makers, and the public.This paper presents the background of the WaDE project, how it was envisioned to function, the types of data it will provide, and why access to the information is important for water managers. The goals of WaDE include the establishment of a governance structure, documentation of the current state agency capabilities and methodologies, and the design of a common data format that targets water data products and/or water‐quantity information. Many of these foundational products have been developed, such as governance workgroups, databases, web services code, and a prototype mapping application for centralized access. A major milestone, still underway, is the distribution and deployment of the databases and web services code within member states’ information technology environments. Lastly, WaDE seeks to encourage the publication of other agency datasets using web services and standardized data formats.
Water and Sediment Quality in the Clinch River,Virginia andTennessee,USA, over Nearly Five Decades
Authors: Price Jennifer E. , Zipper Carl E. , Jones Jess W. , Franck Christopher T. 
Published: July 2014

AbstractThe Clinch River, in eastern United States, supports a diverse freshwater fauna including endangered mussels. Although mussel populations are stable in the Clinch's northeastern Tennessee segment, long‐term declines have been documented upstream in Virginia. We analyzed water and sediment quality data collected by government agencies from the 1960s through 2013 in an effort to inform current management. The river was divided into sections considering data availability and major tributaries. We tested for spatial differences among river sections and for temporal trends, and compared measured values to potentially protective levels if available. Ammonia concentrations approaching and exceeding protective levels were recorded, most often during the 1970s and 1980s in upstream sections. Sediment metals occurred at levels potentially causing biological effects, mainly during the 1980s and 1990s. In the 2000s, water‐column metals have been well below protective levels for general aquatic life. Dissolved solids (DS) increased in most river sections over the study period but mussel‐specific protective levels are not known. Analysis of waterpH, total N, and total P did not generate conservation concern. Enhanced monitoring for sediment metals, water‐column metals, and ionic composition ofDS; closer alignment of agency water monitoring practices in the two states; and research to determine biological effects ofDSat current and anticipated levels can aid future conservation management.
Hypospadias and increased risk for neurodevelopmental disorders
Authors: Butwicka Agnieszka , Lichtenstein Paul , Landén Mikael , Nordenvall Anna S. , Nordenström Anna , Nordenskjöld Agneta , Frisén Louise 
Published: July 2014

BackgroundHypospadias (aberrant opening of the urethra on the underside of the penis) occurs in 1 per 300 newborn boys. It has been previously unknown whether this common malformation is associated with increased psychiatric morbidity later in life. Studies of individuals with hypospadias also provide an opportunity to examine whether difference in androgen signaling is related to neurodevelopmental disorders. To elucidate the mechanisms behind a possible association, we also studied psychiatric outcomes among brothers of the hypospadias patients.MethodsRegistry study within a national cohort of all 9,262 males with hypospadias and their 4,936 healthy brothers born in Sweden between 1973 and 2009. Patients with hypospadias and their brothers were matched with controls by year of birth and county. The following outcomes were evaluated (1) any psychiatric (2) psychotic, (3) mood, (4) anxiety, (5) eating, and (6) personality disorders, (7) substance misuse, (8) attention‐deficit hyperactivity disorder (ADHD), (9) autism spectrum disorders (ASD), (10) intellectual disability, and (11) other behavioral/emotional disorders with onset in childhood.ResultsPatients with hypospadias were more likely to be diagnosed with intellectual disability (OR 3.2; 95% CI 2.8–3.8), ASD (1.4; 1.2–1.7), ADHD (1.5; 1.3–1.9), and behavioral/emotional disorders (1.4; 1.2–1.6) compared with the controls. Brothers of patients with hypospadias had an increased risk of ASD (1.6; 1.3–2.1) and other behavioral/emotional disorders with onset in childhood (1.2; 0.9–1.5) in comparison to siblings of healthy individuals. A slightly higher, although not statistically significant, risk was found for intellectual disability (1.3; 1.0–1.9). No relation between other psychiatric diagnosis and hypospadias was found.ConclusionsThis is the first study to identify an increased risk for neurodevelopmental disorders in patients with hypospadias, as well as an increased risk for ASD in their brothers, suggesting a common familial (genetic and/or environmental) liability.
Host tropism of infectious salmon anaemia virus in marine and freshwater fish species
Authors: Aamelfot M , Dale O B , McBeath A , Falk K 
Published: July 2014

AbstractThe aquatic orthomyxovirus infectious salmon anaemia virus (ISAV) causes a severe disease in farmed Atlantic salmon, Salmo salar L. Although some ISA outbreaks are caused by horizontal transmission of virus between farms, the source and reservoir of the virus is largely unknown and a wild host has been hypothesized. Atlantic salmon are farmed in open net‐pens, allowing transmission of pathogens from wild fish and the surrounding environment to the farmed fish. In this study, a large number of fish species were investigated for ISAV host potential. For orthomyxoviruses, a specific receptor binding is the first requirement for infection; thus, the fish species were investigated for the presence of the ISAV receptor. The receptor was found to be widely distributed across the fish species. All salmonids expressed the receptor. However, only some of the cod‐like and perch‐like fish did, and all flat fish were negative. In the majority of the positive species, the receptor was found on endothelial cells and/or on red blood cells. The study forms a basis for further investigations and opens up the possibility for screening species to determine whether a wild host of ISAV exists.
Relations among school/daycare functioning, fear of hypoglycaemia and quality of life in parents of young children with type 1 diabetes
Authors: Herbert Linda J. , Clary Lauren , Owen Victoria , Monaghan Maureen , Alvarez Vanessa , Streisand Randi 
Published: July 2014

Aims and objectivesTo investigate the type 1 diabetes‐related school/daycare experiences of parents of young children and to examine the relationship among child school/daycare functioning, parent fear of hypoglycaemia and parent type 1 diabetes‐related quality of life.BackgroundParents of young children who attend school/daycare must rely on others for daily type 1 diabetes management. Worry about school/daycare type 1 diabetes management may cause parental distress and contribute to diminished parent quality of life. Parental concerns about type 1 diabetes management in young children in the school/daycare setting have not been well described in the literature.DesignDescriptive correlational and cross‐sectional parent report of questionnaires design.MethodsAs part of a randomised controlled trial for parents of young children with type 1 diabetes, 134 parents completed self‐report measures at baseline. Data included demographic, school/daycare, and medical information, parent reports of child school/daycare functioning, parent fear of hypoglycaemia and parent type 1 diabetes‐related quality of life.ResultsParents of younger children, children on a more intensive medical regimen and children who had experienced type 1 diabetes‐related unconsciousness or seizures had more school/daycare concerns. Parents who perceived their children had higher school/daycare functioning had less fear about hypoglycaemia and reported better type 1 diabetes‐related quality of life. School/daycare functioning and fear of hypoglycaemia were significantly associated with parent type 1 diabetes‐related quality of life.ConclusionsParents' concerns about school/daycare functioning and fear of hypoglycaemia play an important role in parents' type 1 diabetes‐related quality of life.Relevance to clinical practiceMembers of the healthcare team should be aware of concerns related to children attending school/daycare and provide additional support as warranted.