bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning-based measurement of split glomerular filtration rate with 99mTc-diethylenetriamine pentaacetic acid renal scan
Authors: Ha Sejin , Park Byung Soo , Han Sangwon , Oh Jungsu S. , Chae Sun Young , Kim Jae Seung , Moon Dae Hyuk 
Published: July 2024

Abstract
Purpose
To develop a deep learning (DL) model for generating automated regions of interest (ROIs) on 99mTc-diethylenetriamine pentaacetic acid (DTPA) renal scans for glomerular filtration rate (GFR) measurement.

Methods
Manually-drawn ROIs retrieved from a Picture Archiving and Communications System were used as ground-truth (GT) labels. A two-dimensional U-Net convolutional neural network architecture with multichannel input was trained to generate DL ROIs. The agreement between GFR values from GT and DL ROIs was evaluated using Lin’s concordance correlation coefficient (CCC) and slope coefficients for linear regression analyses. Bias and 95% limits of agreement (LOA) were assessed using Bland-Altman plots.

Results
A total of 24,364 scans (12,822 patients) were included. Excellent concordance between GT and DL GFR was found for left (CCC 0.982, 95% confidence interval [CI] 0.981–0.982; slope 1.004, 95% CI 1.003–1.004), right (CCC 0.969, 95% CI 0.968–0.969; slope 0.954, 95% CI 0.953–0.955) and both kidneys (CCC 0.978, 95% CI 0.978–0.979; slope 0.979, 95% CI 0.978–0.979). Bland-Altman analysis revealed minimal bias between GT and DL GFR, with mean differences of − 0.2 (95% LOA − 4.4–4.0), 1.4 (95% LOA − 3.5–6.3) and 1.2 (95% LOA − 6.5–8.8) mL/min/1.73 m² for left, right and both kidneys, respectively. Notably, 19,960 scans (81.9%) showed an absolute difference in GFR of less than 5 mL/min/1.73 m².

Conclusion
Our DL model exhibited excellent performance in the generation of ROIs on 99mTc-DTPA renal scans. This automated approach could potentially reduce manual effort and enhance the precision of GFR measurement in clinical practice.
Organ and tumor dosimetry including method simplification for [177Lu]Lu-PSMA-I&T for treatment of metastatic castration resistant prostate cancer
Authors: Karimzadeh Amir , Schatz Linus , Sauer Markus , Apostolova Ivayla , Buchert Ralph , Klutmann Susanne , Lehnert Wencke 
Published: July 2024

Abstract
Background
Internal dosimetry in individual patients is essential for safe and effective radioligand therapy. Multiple time point imaging for accurate dosimetry is time consuming and hence can be demanding for nuclear medicine departments as well as patients. The objectives of this study were (1) to assess absorbed doses to organs at risk and tumor lesions for [177Lu]Lu-PSMA-I&T using whole body SPECT imaging and (2) to investigate possible simplified dosimetry protocols.

Methods
This study included 16 patients each treated with 4 cycles of [177Lu]Lu-PSMA-I&T. They underwent quantitative whole body SPECT/CT imaging (3 bed positions) at four time points (TP) comprising 2 h, 24 h, 48 h and 72–168 h post-injection (p.i.). Full 3D dosimetry (reference method) was performed for all patients and dose cycles for organs at risk (kidneys, parotid glands and submandibular glands) and up to ten tumor lesions per patient (resulting in 90 lesions overall). The simplified dosimetry methods (SM) included (1) generating time activity curves for subsequent cycles using a single TP of imaging applying the kinetics of dose cycle 1, and for organs at risk also (2) simple extrapolation from dose cycle 1 and (3) from both, dose cycle 1 and 2.

Results
Normalized absorbed doses were 0.71 ± 0.32 mGy/MBq, 0.28 ± 0.12 mGy/MBq and 0.22 ± 0.08 mGy/MBq for kidneys, parotid glands and submandibular glands, respectively. Tumor doses decreased from 3.86 ± 3.38 mGy/MBq in dose cycle 1 to 2.01 ± 2.65 mGy/MBq in dose cycle 4. Compared to the full dosimetry approach the SM 1 using single TP imaging at 48 h p.i. resulted in the most accurate and precise results for the organs at risk in terms of absorbed doses per cycle and total cumulated dose. For tumor lesions better results were achieved using the fourth TP (≥ 72 h p.i.).

Conclusion
Simplification of safety dosimetry protocols is possible for [177Lu]Lu-PSMA-I&T therapy. If tumor dosimetry is of interest a later imaging TP (≥ 72 h p.i.) should be used/added to account for the slower kinetics of tumors compared to organs at risk.
SF6 is a useful expander for post-pneumonectomy syndrome in the long-term course: a case report
Authors: Maeda Koki , Imamura Nobuhiro , Tabata Keisuke , Morizono Shoichiro , Tokunaga Takuya , Takeda Aya , Kamimura Go , Masashi Oniwa , Mizuno Keiko , Aoki Masaya , Ueda Kazuhiro 
Published: July 2024

Abstract
Background
Post-pneumonectomy syndrome (PPS) is a rare but serious condition that can occur after pneumonectomy. It is characterized by a mediastinal shift towards the vacated hemithorax, which can potentially lead to respiratory failure. The management of PPS poses a clinical challenge, especially in the context of the limited availability of certain therapeutic devices due to regulatory restrictions in Japan.

Case presentation
A 36-year-old female with stage IB non-small cell lung cancer underwent left pneumonectomy. Approximately 2 years later, she developed dyspnea. After consulting with our hospital, subsequent imaging revealed an extreme mediastinal shift causing bronchial obstruction. Emergency thoracotomy and subsequent sulfur hexafluoride (SF6) injections were successfully used to manage her condition. Over the course of follow-up, the interval between SF6 injections was extended from 3 to 11 months, indicating an improvement in the intrathoracic condition.

Conclusions
This case illustrates the efficacy of SF6 gas in treating PPS and in reducing the frequency of medical interventions. SF6 gas administration is safe and effective for the treatment of patients with PPS.
Frequency of and sex differences in cancer treatment-related cardiac dysfunction in trastuzumab-treated patients with salivary gland cancer: a retrospective cohort study
Authors: Tamura Yudai , Tamura Yuichi , Tada Yuichiro 
Published: July 2024

Abstract
Background
Trastuzumab treatment for salivary gland, gastric, and breast cancer commonly causes cancer treatment-related cardiac dysfunction (CTRCD). CTRCD incidence by sex has not been well studied.

Methods
This retrospective cohort study investigated frequency of and sex differences in CTRCD in patients with salivary gland cancer treated with trastuzumab at our hospital from April 2017 to March 2022. All patients underwent echocardiography at baseline and after the first, third, and sixth trastuzumab courses. We measured changes in global and regional longitudinal strain (LS) after trastuzumab administration. CTRCD was defined by left ventricular ejection fraction (LVEF) or global LS (GLS). The results were compared by sex.

Results
We recorded clinical data of 49 patients (median age [IQR], 65 [55–71] years; males [75.5%]). The median follow-up period after the sixth trastuzumab course was 120 (111–128) days. One female patient and no male patient had CTRCD defined by LVEF, and two female patients (16.7%) and seven male patients (18.9%) had CTRCD, defined by GLS. The Kaplan–Meier curves showed no significant difference in CTRCD frequency, defined by GLS (log-rank, p = 0.88), between female and male patients. In the univariate analysis, sex was not associated with CTRCD, defined by GLS. A significant difference in apical LS was observed between baseline and the third follow-up results of male patients.

Conclusions
In this study, CTRCD incidence was not significantly different between male and female patients with salivary gland cancer treated with trastuzumab. Although most previous studies have looked at female patients with breast cancer, a male patient may be found to be at similar risk of myocardial damage.
Self and proxy symptom reporting in glioma patient-caregiver dyads: the role of psychosocial function in rating accuracy
Authors: Whisenant Meagan , Snyder Stella , Weathers Shiao-Pei , Bruera Eduardo , Milbury Kathrin 
Published: July 2024

Abstract
Background
Illness-related communication and depressive symptoms within families may play an important role in caregivers’ ability to accurately understand patients’ symptom burden. We examined the associations between these psychosocial factors and symptom accuracy in patients with glioma and their family caregivers.

Methods
Patients and caregivers (n = 67 dyads) completed measures of depressive symptoms (CES-D), illness communication (CICS), and QOL (SF-36). Patients reported on their own cancer-related symptoms (MDASI-BT) while caregivers reported on their perception of the patients’ symptoms (i.e., proxy reporting). Paired t-tests and difference scores were used to test for agreement (absolute value of difference scores between patients and caregiver proxy symptom and interference severity reports) and accuracy (caregiver underestimation, overestimation, or accurate estimation of patient symptom and interference severity).

Results
Clinically significant disagreement was found for all means scores of the MDASI-BT subscales except for gastrointestinal symptoms and general symptoms. Among caregivers, 22% overestimated overall symptom severity and 32% overestimated overall symptom interference. In addition, 13% of caregivers underestimated overall symptom severity and 21% of caregivers underestimated overall symptom interference. Patient illness communication was associated with agreement of overall symptom severity (r=−0.27, p = 0.03) and affective symptom subscale (r=−0.34, p < 0.01). Caregivers’ reporting of illness communication (r=−0.33, p < 0.01) and depressive symptoms (r = 0.46, p < 0.0001) were associated with agreement of symptom interference. Caregiver underestimating symptom severity was associated with lower patient physical QOL (p < 0.01); caregiver underestimating symptom interference was associated with lower patient physical QOL (p < 0.0001) and overestimating symptom interference was associated with lower patient physical QOL (p < 0.05). Patient and caregiver mental QOL was associated with caregiver underestimating (p < 0.05) and overestimating (p < 0.05) symptom severity.

Conclusion
The psychosocial context of the family plays an important role in the accuracy of symptom understanding. Inaccurately understanding patients experience is related to poor QOL for both patients and caregivers, pointing to important targets for symptom management interventions that involve family caregivers.
Revolutionizing anemia detection: integrative machine learning models and advanced attention mechanisms
Authors: Ramzan Muhammad , Sheng Jinfang , Saeed Muhammad Usman , Wang Bin , Duraihem Faisal Z. 
Published: July 2024

AbstractThis study addresses the critical issue of anemia detection using machine learning (ML) techniques. Although a widespread blood disorder with significant health implications, anemia often remains undetected. This necessitates timely and efficient diagnostic methods, as traditional approaches that rely on manual assessment are time-consuming and subjective. The present study explored the application of ML – particularly classification models, such as logistic regression, decision trees, random forest, support vector machines, Naïve Bayes, and k-nearest neighbors – in conjunction with innovative models incorporating attention modules and spatial attention to detect anemia. The proposed models demonstrated promising results, achieving high accuracy, precision, recall, and F1 scores for both textual and image datasets. In addition, an integrated approach that combines textual and image data was found to outperform the individual modalities. Specifically, the proposed AlexNet Multiple Spatial Attention model achieved an exceptional accuracy of 99.58%, emphasizing its potential to revolutionize automated anemia detection. The results of ablation studies confirm the significance of key components – including the blue-green-red, multiple, and spatial attentions – in enhancing model performance. Overall, this study presents a comprehensive and innovative framework for noninvasive anemia detection, contributing valuable insights to the field.
Predicting Benefit From FOLFOXIRI Plus Bevacizumab in Patients With Metastatic Colorectal Cancer
Authors: Bond Marinde J.G. , van Smeden Maarten , Degeling Koen , Cremolini Chiara , Schmoll Hans-Joachim , Antoniotti Carlotta , Lonardi Sara , Murgioni Sabina , Rossini Daniele , Ibach Stefan , Koopman Miriam , Swijnenburg Rutger-Jan , Punt Cornelis J.A. , May Anne M. , Kwakman Johannes J.M. 
Published: July 2024

PURPOSE Patient outcomes may differ from randomized trial averages. We aimed to predict benefit from FOLFOXIRI versus infusional fluorouracil, leucovorin, and oxaliplatin/fluorouracil, leucovorin, and irinotecan (FOLFOX/FOLFIRI), both plus bevacizumab, in patients with metastatic colorectal cancer (mCRC). METHODS A Cox model with prespecified clinical, molecular, and laboratory variables was developed in 639 patients from the TRIBE2 trial for predicting 2-year mortality. Data from the CHARTA (n = 232), TRIBE1 (n = 504), and CAIRO5 (liver-only mCRC, n = 287) trials were used for external validation and heterogeneity of treatment effects (HTE) analysis. This involves categorizing patients into risk groups and assessing treatment effects across these groups. Performance was assessed by the C-index and calibration plots. The C-for-benefit was calculated to assess evidence for HTE. The c-for-benefit is specifically designed for HTE analysis. Like the commonly known c-statistic, it summarizes the discrimination of a model. Values over 0.5 indicate evidence for HTE. RESULTS In TRIBE2, the overoptimism-corrected C-index was 0.66 (95% CI, 0.63 to 0.69). At external validation, the C-index was 0.69 (95% CI, 0.64 to 0.75), 0.68 (95% CI, 0.64 to 0.72), and 0.65 (95% CI, 0.65 to 0.66), in CHARTA, TRIBE1, and CAIRO5, respectively. Calibration plots indicated slight underestimation of mortality. The c-for-benefit indicated evidence for HTE in CHARTA (0.56, 95% CI, 0.48 to 0.65), but not in TRIBE1 (0.49, 95% CI, 0.44 to 0.55) and CAIRO5 (0.40, 95% CI, 0.32 to 0.48). CONCLUSION Although 2-year mortality could be reasonably estimated, the HTE analysis showed that clinically available variables did not reliably identify which patients with mCRC benefit from FOLFOXIRI versus FOLFOX/FOLFIRI, both plus bevacizumab, across the three studies.
Preventing chemotherapy-induced peripheral neuropathy with acupuncture, a multinational parallel randomized controlled trials project (PACT).
Authors: Lu Weidong , Giobbie-Hurder Anita , Tanasijevic Anna , Baedorf Kassis Sylvia , Diederich Ellie , Sahraoui Aliya , Park Sung Hwan , Jeong Young Ju , Shin Im Hee , Yao Chang , Zhang Xiping , Jung Hyun Jung , Lee Na-Rang , Yao Yao , Bao Chao , Bao Ting , Yang EunMee , Knoerl Robert , Bierer Barbara E , Ligibel Jennifer A. 
Published: July 2024

TPS12156 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant challenge for patients (pts) with breast cancer treated with taxanes and platinum compounds. CIPN severely affects quality of life, leading to paresthesia and pain, and often results in dose modifications and discontinuation of treatment. Although preliminary trials suggest the effectiveness of acupuncture in managing existing symptoms of CIPN, the use of acupuncture to prevent CIPN is not well studied. Prior studies provide inconclusive results, underscoring the need for more rigorous investigation. We designed an international study, PACT, to evaluate the impact of acupuncture on the prevention of CIPN in breast cancer pts who undergo adjuvant or neoadjuvant taxane-based chemotherapy. Methods: PACT is a coordinated multi-national study consisting of three parallel randomized trials in USA, China, and South Korea, using the same inclusion/exclusion criteria, randomization, interventions, and validated measures. PACT is designed to evaluate the effectiveness of acupuncture in preventing CIPN in pts undergoing taxane-based chemotherapy for early-stage breast cancer. Participants include pts with newly diagnosed stage I-III breast cancer without preexisting neuropathy, scheduled for adjuvant or neoadjuvant taxane-based chemotherapy. Target enrollment is 140 pts from three sites: Dana-Farber Cancer Institute (USA) (n=100), Jiangsu Province Hospital of Chinese Medicine (China) (n = 20) and the Daegu Catholic University Medical Center (South Korea) (n=20), randomized (1:1) to the acupuncture arm or a control. The acupuncture arm receives a standardized protocol of 1-2 sessions per week for 12 weeks (total of 14 sessions). The control arm receives relaxation exercises with nature scenery videos for 14 sessions. The follow-up period for both arms is 12 weeks. Main measures include The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CIPN20, QLQ-30 and Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) CIPN items. The primary outcome measure is the change in CIPN severity, assessed using the EORTC QLQ-CIPN20 sensory subscale, between baseline and week 12, with secondary outcomes including occurrence of CIPN and maximum CIPN scores, pain, sleep quality, and overall quality of life. A planned pooled analysis of individual patient data will be performed. The ethics review committee of each site has approved the study. Today, 89 (64%) of the planned 140 participants have been enrolled. Clinical trial information: NCT05528263 , ChiCTR2200066714, KCT0008470.
Narrowband stimulated Raman scattering and molecular modulation in anti-resonant hollow-core fibres
Authors: Arcos P. , Mena A. , Sánchez-Hernández M. , Arrospide E. , Aldabaldetreku G. , Illarramendi M. A. , Zubia J. , Novoa D. 
Published: July 2024

Abstract
Raman scattering is the inelastic process where photons bounce off molecules, losing energy and becoming red-shifted. This weak effect is unique to each molecular species, making it an essential tool in, e.g., spectroscopy and label-free microscopy. The invention of the laser enabled a regime of stimulated Raman scattering (SRS), where the efficiency is greatly increased by inducing coherent molecular oscillations. However, this phenomenon required high intensities due to the limited interaction volumes, and this limitation was overcome by the emergence of anti-resonant fibres (ARFs) guiding light in a small hollow channel over long distances. Based on their unique properties, this Perspective reviews the transformative impact of ARFs on modern SRS-based applications ranging from development of light sources and convertors for spectroscopy and materials science, to quantum technologies for the future quantum networks, providing insights into future trends and the expanding horizons of the field.
The impact of overweight and obesity on the results of laparoscopic ventral hernia repair, including robot-assisted repair - a literature review
Authors: Ostojska Magdalena , Kałuża Izabela , Górska Magdalena , Miazga Małgorzata , Serkis Barbara , Golemo Jagna , Celichowska Magdalena , Dziuba Gabriela , Bentkowska Zuzanna , Dębińska Julia 
Published: July 2024

Obesity is the fifth leading cause of death worldwide. In turn, ventral hernias (including an inguinal hernias) are one of the most common cases in general surgery. Minimally invasive techniques (laparoscopic or robot-assisted procedures) are becoming more and more popular in ventral hernia treatment compared to open procedures.
The aim of this study is to analyze the impact of body mass index (BMI) value on the efficacy and safety of laparoscopic ventral hernia repairs, including inguinal hernia repairs.
Numerous studies evaluating this relationship are available. In most studies, There were also no statistically significant differences in the rate of intraoperative complications, the median operative time, the median length of hospital stay, the rate of postoperative pain, the surgical site infection, the rate of postoperative complications, the median time to recurrence, and the rate of early and late recurrences between groups with different BMI values. Moreover, studies proved that laparoscopic ventral hernia repair in obese patients is more effective compared to the open repair.
The analysis revealed that high BMI values do not have a statistically significant impact on the outcomes of laparoscopic repair, including robot-assisted laparoscopic repair, in patients with ventral hernias. However, it should be noted that the analyzed studies often have limitations. For this reason, it is essential to conduct multicenter studies and perform long-term evaluations of patients.
Return to the United States: Impact of Reshoring Announcements and Reshoring Risks on Market Valuation
Authors: Cheng Miyuki P. S. , Tang Christopher , Lo Chris K. Y. , Yeung Andy C. L. , Lam Hugo K. S. 
Published: July 2024

With soaring labor and logistics costs in developing countries, supply chain disruptions during the COVID-19 pandemic triggered Western firms to “reshore” some of their offshore operations (performed in-house or outsourced) for certain strategically important products or production processes from foreign countries to their home countries. Although reshoring can create more domestic jobs and reduce supply chain risks, the impact of various external and internal risks associated with reshoring on market reaction remains unclear. This observation motivates us first to conduct a text mining analysis, revealing four important types of reshoring risks inherent to (1) foreign currency fluctuation, (2) intellectual property (IP) protection, (3) reshoring types (in-house, insourced, or outsourcing-to-outsourcing (OTO)), and (4) reshoring location choice (Republican- versus Democrat-led states). We then examine how these risk factors help explain the variations in reshoring’s market valuation based on 281 reshoring initiatives of 132 publicly traded firms in the United States announced between 2009 and 2022. Our empirical analysis reveals that the market reacts more positively to a firm’s reshoring announcement when the firm reshores under a high-currency-fluctuation environment or from countries with weak IP protection. However, the market’s reaction is more negative when the firm’s reshoring announcement entails insourced reshoring operations or when the reshored location is a Democrat- rather than Republican-led state. We do not find a significant market reaction to OTO reshoring. This paper was accepted by Vishal Gaur, operations management. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00599 .
Decontamination of a surgical mask with UV-C irradiation: analysis of experimental results with optical simulations
Authors: Kiiskinen Titta , Mangs Oliver , Virkajärvi Jussi , Elsehrawy Farid , Salo Satu , Miettinen Arttu , Halme Janne , Harlin Ali , Ketoja Jukka A. 
Published: July 2024

The suitability of ultraviolet-C (UV-C) irradiation for the decontamination of a surgical face mask was studied by decontamination experiments and carried out using Staphylococcus aureus and MS2 microbes. A moderate dosage level of 0.22J/cm2 achieved within 2 min led to an over 6-log10 reduction in viable microbe contamination of the inner filtering layer. The underlying reason for this effective decontamination of fibers with small external UV-C dosage was explored with ray-tracing optical simulations, supported by optical measurements on reflection and transmission. The model 3D fiber network was constructed from X-ray tomography images of the layered mask structure consisting of polypropylene fibers. Both simulations and optical measurements indicated that UV light was able to penetrate even the deepest material regions. The simulations show that, despite radiation reflection from the outer mask layer, microbes in the actual filtering layer are affected by the radiation with increased probability due to multiple refraction and scattering of UV light from the inner fibers.