bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidimensional Measure of Well-Being, Translation, Factor Structure, Measurement Invariance, Reliability and Validity of the PERMA-Profiler in Spain
Authors: Martín-Díaz María Dolores , Fernández-Abascal Enrique G. 
Published: June 2024

AbstractThe main objective of this study is to examine the psychometric properties of the PERMA-Profiler in a Spanish context. The PERMA-Profiler, developed by Butler & Kern (Int J Wellbeing 6(3):1-48, 2016) to measure Seligman’s (Flourish: A visionary new understanding of happiness and well-being, 2011) PERMA model of flourishing, consists of five domains that assess well-being: Positive Emotion (P), Engagement (E), Relationships (R), Meaning (M), and Accomplishment (A). We translated and adapted the PERMA-Profiler, analyzed the instrument’s reliability, its validity based on an internal structure through three confirmatory factor analyses, gender and age invariance, and its convergent and discriminant validity. A total of 2525 participants completed all measures. The results of the analyses to confirm the internal consistency are very acceptable in all the domains and in Overall Well-being (PERMA), except for the Engagement domain. The results of three confirmatory factor analyses show that the model of five independent interrelated factors (domains) presents the best fit. The analysis shows the invariance across gender and age groups. The analyses of the convergent validity show that are positively and significantly related to satisfaction with life (SWLS), to the six evaluated dimensions of psychological well-being (PWB), to positive affect (PANAS) and dispositional optimism (LOT-R) and the general physical and mental health status (SF-36). The discriminant validity analyses show that are related negatively and significantly to negative affect (PANAS), the total score of depression (BDI-II) and the Cognitive-Affective and Somatic-Motivational factors. The findings of this study indicate that the PERMA-Profiler is transferable to the Spanish context, and the Spanish version is a reliable and valid measure of well-being.
TeleStroke: real-time stroke detection with federated learning and YOLOv8 on edge devices
Authors: Elhanashi Abdussalam , Dini Pierpaolo , Saponara Sergio , Zheng Qinghe 
Published: June 2024

AbstractStroke, a life-threatening medical condition, necessitates immediate intervention for optimal outcomes. Timely diagnosis and treatment play a crucial role in reducing mortality and minimizing long-term disabilities associated with strokes. This study presents a novel approach to meet these critical needs by proposing a real-time stroke detection system based on deep learning (DL) with utilization of federated learning (FL) to enhance accuracy and privacy preservation. The primary objective of this research is to develop an efficient and accurate model capable of discerning between stroke and non-stroke cases in real-time, facilitating healthcare professionals in making well-informed decisions. Traditional stroke detection methods relying on manual interpretation of medical images are time-consuming and prone to human error. DL techniques have shown promise in automating this process, yet challenges persist due to the need for extensive and diverse datasets and privacy concerns. To address these challenges, our methodology involves utilization and assessing YOLOv8 models on comprehensive datasets comprising both stroke and non-stroke based on the facial paralysis of the individuals from the images. This training process empowers the model to grasp intricate patterns and features associated with strokes, thereby enhancing its diagnostic accuracy. In addition, federated learning, a decentralized training approach, is employed to bolster privacy while preserving model performance. This approach enables the model to learn from data distributed across various clients without compromising sensitive patient information. The proposed methodology has been implemented on NVIDIA platforms, utilizing their advanced GPU capabilities to enable real-time processing and analysis. This optimized model has the potential to revolutionize stroke diagnosis and patient care, promising to save lives and elevate the quality of healthcare services in the neurology field.
Epistemic Bystander
Authors: Schwengerer Lukas 
Published: June 2024

Abstract
Epistemic bystanding occurs when an agent has all the competences, knowledge and opportunity to prevent another person from forming a false or risky belief, but does not prevent the belief formation. I provide a definition of an epistemic bystander and explain the mechanism that makes someone an epistemic bystander. I argue that the phenomenon is genuinely epistemic and not merely linguistic. Moreover, I propose an account of the mechanism of epistemic bystanding building on Ishani Maitra’s notion of licensing. An epistemic bystander licenses a risky belief-forming process in another person and thereby performs a blameworthy epistemic action. This form of licensing explains the distinctive wrong of being an epistemic bystander.
Intentional Imperfection Program: A pilot randomised controlled trial to help university students manage perfectionism
Authors: Visvalingam Shanara , Matheson Angelica C. , Magson Natasha R. , Norberg Melissa M. 
Published: June 2024

Abstract
Given that perfectionism has been associated with interpersonal, academic, and mental health difficulties in university students, helping them manage their perfectionism is crucial. This pilot trial examined the feasibility, acceptability, and potential efficacy of an online perfectionism program designed to target the mechanisms that link perfectionism to psychological distress. Seventy first-year psychology students from Macquarie University with high levels of perfectionism were recruited into this two-arm pilot trial and randomised to either the intervention (i.e., perfectionism program) or attention placebo control (i.e., lifestyle program) condition. We assessed indicators of feasibility and acceptability, as well as measures related to perfectionism, psychological distress, emotion regulation skills, interpersonal and academic functioning at baseline, one-month post treatment, and three-month follow-up (blinded outcome assessment). Our analyses revealed that, while participants expressed overall satisfaction with the program, there was low engagement with it (Mcompletion rate=36.23%), and retention in the study was low (response rates for post-treatment: 65.71% and follow-up: 48.57%). Bearing this in mind, our linear mixed model analyses revealed greater reductions in perfectionistic traits and cognitions, interpersonal hostility, and loneliness, as well as increases in self-compassion in the intervention group compared to the control group at post-treatment and/or follow-up. However, we did not observe statistically significant changes in other important treatment outcomes (e.g.,psychological distress). Given these findings, adjustments to improve engagement and retention should occur before proceeding with a larger, definitive trial. This trial was retrospectively registered on the Australian and New Zealand Clinical Trials Registry (no. ACTRN12622000960752).
Candida albicans — der Pilz in uns
Authors: Brunke Sascha , Hube Bernhard 
Published: June 2024

AbstractFungal infections are often underestimated as a significant cause of mortality. Most pathogenic fungi originate from the environment, but one of the most common and important fungal pathogens, Candida albicans, lives as a commensal within the vast majority of humans. It is becoming more and more evident that many adaptations that allow its commensal lifestyle also support its pathogenicity. These include morphological flexibility and toxin production that serve as competition and virulence factors.
Zytotoxische CD8+-T-Zellen im Alter: unterschätzte Killer?
Authors: Lis Annette , Kaschek Lea , Zöphel Dorina 
Published: June 2024

AbstractAging leads to various alterations in immune cell functions. Here, we report our surprising findings that despite immunosenescence, CD8+ T cells’ cytotoxic efficiency increases with age. The FRET-based apoptosis sensor pCasper, stably transfected into tumor cells, revealed fundamental changes in the cytotoxic mechanisms. Antigen-specific CD8+ T cells from elderly OT-I mice shift from apoptotic to necrotic killers. This capability might affect cell-based immunotherapies in old age.
Zellen sind Individualisten — Entscheidungsprozesse auf Einzelzellebene
Authors: Lenhardt Sonja , Hartmann Laura , Legewie Stefan , Loewer Alexander 
Published: June 2024

AbstractDecision-making is a fundamental aspect of life. However, our understanding of how cells encode and decode information to enable reliable fate decisions remains limited. Employing live cell imaging and automated analysis, our research unveils substantial heterogeneity in the cellular response to TGFβ and sheds light on the intricate link between the dynamics of SMAD signaling, the state of individual cells and their fate decisions.
Antikörper-basierte Zytokinmimetika
Authors: Unmuth Laura , Lipinski Britta , Pekar Lukas , Evers Andreas , Elter Desislava , Zielonka Stefan 
Published: June 2024

AbstractAntibody-based cytokine mimetics emerged as promising entities in order to modulate an immune response. These surrogate agonists are bi- and multifunctional antibody-derived molecules that mimic the function of a cytokine by agonizing a specific cytokine receptor. Due to the high modularity of antibody-based building blocks, cytokine functionalities can be highly engineered, for instance with regards to signalling strength and bias.
The Mediatization of Jewish–Muslim Dialogue in Germany Amid COVID-19
Authors: Peretz Dekel 
Published: June 2024

AbstractIn the wake of the coronavirus disease 2019 (COVID-19) pandemic, religious organizations increasingly mediatized their activities. Studies examining this process mostly focused on communal offerings, while ignoring how rapid mediatization affected programs geared toward interfaith dialogue. This paper examines the effects and possibilities of this shift to virtual spaces by focusing on frameworks that promote Jewish–Muslim dialogue in Germany. It traces how Jews and Muslims intervene in popular discourse using social media platforms to self-define their respective religions and the relationship between them. In this process, those involved in creating virtual spaces focused on the intersectionality between gender biases and Christonormativity. This paper utilizes a broad methodological approach, including participant observation in dialogue events in virtual spaces, discursive analyses of videos and podcasts, and qualitative interviews with Jews and Muslims involved in the creation of virtual spaces. The first section discusses Jewish–Muslim encounters occurring in organized dialogue events on video communication platforms that are ephemeral in nature (no recordings). The subsequent sections analyze German-language formats that have a representative character and are streamed, recorded, and presented on social media platforms.
Development of a Pt(II) compound based on indocyanine green@human serum albumin nanoparticles: integrating phototherapy, chemotherapy and immunotherapy to overcome tumor cisplatin resistance
Authors: Man Xue-Yu , Sun Ze-Wen , Li Shan-He , Xu Gang , Li Wen-Juan , Zhang Zhen-Lei , Liang Hong , Yang Feng 
Published: June 2024

AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy. To this end, we obtained a platinum compound (C5) with significant cytotoxicity in the cisplatin-resistant SKOV-3 cells (SKOV-3/DDP), and then innovatively constructed photosensitizer (indocyanine green (ICG))-encapsulated HSA-C5 complex nanoparticles (ICG@HSA-C5 NPs). The ICG@HSA-C5 NPs exhibited excellent photothermal performances in vitro and in vivo. Importantly, the in vivo results revealed that HSA enhanced the antitumor effect of C5 and that the combination of chemotherapy and PTT could significantly inhibit cisplatin-resistant tumor growth and improved the targeting abilities of C5 and ICG, and reduced their side effects. We also confirmed that ICG@HSA-C5 NPs killed the SKOV-3/DDP cells via gasdermin E (GSDME)-mediated pyroptosis and pyroptosis-induced immune responses, thereby synergistically leading to the death of the SKOV-3/DDP cells.
Graphical abstract
Estimating Risk Factor Time Paths Among People with Type 2 Diabetes and QALY Gains from Risk Factor Management
Authors: Gao Ni , Dakin Helen A. , Holman Rury R. , Lim Lee-Ling , Leal José , Clarke Philip 
Published: June 2024

Abstract
Objectives
Most type 2 diabetes simulation models utilise equations mapping out lifetime trajectories of risk factors [e.g. glycated haemoglobin (HbA1c)]. Existing equations, using historic data or assuming constant risk factors, frequently underestimate or overestimate complication rates. Updated risk factor time path equations are needed for simulation models to more accurately predict complication rates.

Aims
(1) Update United Kingdom Prospective Diabetes Study Outcomes Model (UKPDS-OM2) risk factor time path equations; (2) compare quality-adjusted life-years (QALYs) using original and updated equations; and (3) compare QALY gains for reference case simulations using different risk factor equations.

Methods
Using pooled contemporary data from two randomised trials EXSCEL and TECOS (n = 28,608), we estimated: dynamic panel models of seven continuous risk factors (high-density lipoprotein cholesterol, low density lipoprotein cholesterol, HbA1c, haemoglobin, heart rate, blood pressure and body mass index); two-step models of estimated glomerular filtration rate; and survival analyses of peripheral arterial disease, atrial fibrillation and albuminuria. UKPDS-OM2-derived lifetime QALYs were extrapolated over 70 years using historical and the new risk factor equations.

Results
All new risk factor equation predictions were within 95% confidence intervals of observed values, displaying good agreement between observed and estimated values. Historical risk factor time path equations predicted trial participants would accrue 9.84 QALYs, increasing to 10.98 QALYs using contemporary equations.

Discussion
Incorporating updated risk factor time path equations into diabetes simulation models could give more accurate predictions of long-term health, costs, QALYs and cost-effectiveness estimates, as well as a more precise understanding of the impact of diabetes on patients’ health, expenditure and quality of life.

Trial Registration
ClinicalTrials.gov NCT01144338 and NCT00790205
Judgement and Decision Making in Clinical and Return-to-Sports Decision Making: A Narrative Review
Authors: Yung Kate K. , Ardern Clare L. , Serpiello Fabio R. , Robertson Sam 
Published: June 2024

AbstractMaking return-to-sport decisions can be complex and multi-faceted, as it requires an evaluation of an individual’s physical, psychological, and social well-being. Specifically, the timing of progression, regression, or return to sport can be difficult to determine due to the multitude of information that needs to be considered by clinicians. With the advent of new sports technology, the increasing volume of data poses a challenge to clinicians in effectively processing and utilising it to enhance the quality of their decisions. To gain a deeper understanding of the mechanisms underlying human decision making and associated biases, this narrative review provides a brief overview of different decision-making models that are relevant to sports rehabilitation settings. Accordingly, decisions can be made intuitively, analytically, and/or with heuristics. This narrative review demonstrates how the decision-making models can be applied in the context of return-to-sport decisions and shed light on strategies that may help clinicians improve decision quality.
Age of First Exposure Does Not Relate to Post-Career Health in Former Professional American-Style Football Players
Authors: Terry Douglas P. , Grashow Rachel , Iverson Grant L. , Atkeson Paula , Rotem Ran , Eagle Shawn R. , Daneshvar Daniel H. , Zuckerman Scott L. , Zafonte Ross D. , Weisskopf Marc G. , Baggish Aaron 
Published: June 2024

Abstract
Objective
Prior studies examining small samples of symptomatic former professional football players suggest that earlier age of first exposure (AFE) to American football is associated with adverse later life health outcomes. This study examined a larger, more representative sample of former professional American football players to assess associations between AFE before age 12 (AFE < 12) and clinical outcomes compared with those who started at age 12 or older (AFE 12 +).

Methods
Former professional American football players who completed a questionnaire were dichotomized into AFE < 12 and AFE 12 + . AFE groups were compared on outcomes including symptoms of depression and anxiety, perceived cognitive difficulties, neurobehavioral dysregulation, and self-reported health conditions (e.g., headaches, sleep apnea, hypertension, chronic pain, memory loss, dementia/Alzheimer’s disease, and others).

Results
Among 4189 former professional football players (aged 52 ± 14 years, 39% self-reported as Black), univariable associations with negligible effect sizes were seen with AFE < 12, depressive symptoms (p = 0.03; η2 = 0.001), and anxiety-related symptoms (p = 0.02; η2 = 0.001) only. Multivariable models adjusting for age, race, body mass index, playing position, number of professional seasons, and past concussion burden revealed no significant relationships between AFE < 12 and any outcome. Linear and non-linear models examining AFE as a continuous variable showed similar null results.

Conclusions
In a large cohort of former professional American-style football players, AFE was not independently associated with adverse later life outcomes. These findings are inconsistent with smaller studies of former professional football players. Studies examining AFE in professional football players may have limited utility and generalizability regarding policy implications for youth sports.
Stability of highly inclined non-circular wellbores in isotropic formations
Authors: Oyedokun Oluwafemi , Schubert Jerome 
Published: June 2024

AbstractThe shear and tensile stabilities of highly inclined non-circular wellbores are investigated in this study. Using the equivalent-ellipse hypothesis, the non-circular geometry was approximated as an ellipse, and the corresponding stress concentration equations are presented. With the new set of stress concentration equations, a comprehensive study of the tensile and shear stabilities of an elliptical borehole was conducted, including the impact of well inclination and azimuthal angles, horizontal stress difference, degree of ellipticity, and orientation of the maximum horizontal stress to the major axis of the ellipse. Using five commonly used shear failure criteria, we observed that both Mohr–Coulomb and Drucker Prager (inscribed) failure criteria predicted higher collapse pressures, relative to the others including Drucker Prager (inscribed), Mogi-Coulomb, and Modified Lade. While Drucker Prager's (circumscribed) failure criterion underestimates the collapse pressure. Both the linear elastic and poroelastic models were used in investigating the fracture initiation orientation and pressure of highly inclined elliptical boreholes. The prediction from the poroelastic model is always less than the linear elastic model. In some instances, they predict different fracture initiation orientations. From this study, we observed that generally, a near-circular wellbore is more stable than elliptical borehole in both shear and tension. Nevertheless, there are some well inclination and azimuthal angles than can make an elliptical borehole have more shear and tensile stabilities than a near-circular wellbore.
A Multivariate Geostatistical Framework to Assess the Spatio-Temporal Dynamics of Air Pollution and Land Surface Temperature in Bangladesh
Authors: Rahaman Sk Nafiz , Nelson Jake , Ali Al Artat Bin , Shermin Nishat , Pricope Narcisa G. , Al Kafy Abdulla , Sabuj Md Shahaduzzaman , Toa Sharmin Sultana 
Published: June 2024

Abstract
In the context of escalating urban heat dynamics, the effect of air pollutants on Land Surface Temperature (LST) is an urgent concern, especially in the Global South. These regions are experiencing rapid industrialization, leading to an increase in greenhouse gas concentrations. Although the heat-absorbing capacity of air pollutants is well-recognized, the spatiotemporal relationship between these pollutants and LST remains underexplored, particularly in densely populated and industrialized metropolitan areas. Moreover, studies examining multiple pollutants simultaneously to understand their cumulative impact on surface temperature anomalies are scarce. Our study addresses this research gap by developing a spatial–temporal framework using remote sensing data from Google Earth Engine (GEE). We assessed the levels of Nitrogen Dioxide (NO2), Carbon Monoxide (CO), Aerosol Optical Depth (AOD), Ozone (O3), Sulfur Dioxide (SO2), and Formaldehyde (HCHO) in Bangladesh. Utilizing Emerging Hotspot Analysis and Geographically Weighted Regression (GWR) and complementing these with Principal Component Analysis (PCA) to create a Pollutant Impact Index (PII), we provide a detailed understanding of pollutant's impact on LST. The results revealed a global R-squared value of 0.61 with maximum local R-squared value of 0.68. Over 30% of the areas studied exhibit high-high clusters for air pollutant coefficients, with notably alarming levels of NO2 and O3, affecting 48.53% and 54.67% of the area, respectively. The PCA underscored the significant role of these pollutants, with the first three principal components accounting for 75% of the variance. Notably, the spatial distribution of the PII across Bangladesh showed substantial regional variations. Urban areas, like Dhaka and Sylhet, exhibited much higher PII values compared to less industrialized regions. These insights highlight the need for targeted environmental strategies to mitigate the impact of air pollution on urban heat dynamics and public health. The study’s findings underscore the urgency of addressing these environmental challenges, particularly in rapidly developing areas of the Global South.
Thirty-year mystery of birth and fertility in China
Authors: Qiao Xiaochun 
Published: June 2024

AbstractThis manuscript provides a comprehensive analysis of the discrepancies in China’s reported and estimated crude birth rates (CBR) over the thirty years from 1990 to 2020, revealing substantial underreporting influenced by family planning policies and demographic shifts. Utilizing data from National Population Censuses and multiple national surveys, this study highlights how birth numbers, crude birth rates, and fertility rates have been consistently adjusted to align with policy narratives rather than actual demographic data. The findings indicate significant differences between direct calculations, reported figures, subsequent post-census adjustments, and estimations for the reality, reflecting a complex interplay of governmental data management and policy enforcement. By reconstructing the thirty-year trajectory of CBR and fertility in China, this paper offers critical insights into the implications of data accuracy for policy making and demographic analysis. The study concludes that the lack of accurate data over the thirty years and official misjudgments of fertility levels are the most important reasons for the failure to liberalize the fertility policy as early as possible.