bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Cyclopropenimine‐Catalyzed Enantioselective Mannich Reactions of tert‐Butyl Glycinates with N‐Boc‐Imines.
Authors: Bandar Jeffrey S. , Lambert Tristan H. 
Published: January 2014

AbstractCyclopropenimine is an efficient and selective catalyst for Mannich reactions between glycine imines with aryl and aliphatic N‐Boc‐aldimines with high levels of enantio‐ and diastereoselectivity.
ChemInform Abstract: Copper Oxide Nanoparticles Supported on Graphene Oxide‐Catalyzed S‐Arylation: An Efficient and Ligand‐Free Synthesis of Aryl Sulfides.
Authors: Kamal Ahmed , Srinivasulu Vunnam , Murthy J. N. S. R. C. , Shankaraiah Nagula , Nagesh Narayana , Reddy T. Srinivasa , Rao A. V. Subba 
Published: January 2014

AbstractA wide range of symmetrical and unsymmetrical aryl sulfides is prepared from aryl halides with thiols or thiourea as a sulfur source.
ChemInform Abstract: Facile Synthesis of Dibranched Conjugated Dienes via Palladium‐Catalyzed Oxidative Coupling of N‐Tosylhydrazones.
Authors: Jiang Huanfeng , He Li , Li Xianwei , Chen Huoji , Wu Wanqing , Fu Wei 
Published: January 2014

AbstractA facile and highly regioselective oxidative coupling of N‐tosylhydrazones (I) and further transformations of the 2,3‐disubstituted 1,3‐butadienes (II) formed via Diels—Alder reactions and indene synthesis are reported.
ChemInform Abstract: In(III)PhCO2H Binary Acid Catalyzed Tandem [2 + 2] Cycloaddition and Nazarov Reaction Between Alkynes and Acetals.
Authors: Zhu Lihui , Xi Zhi‐Guo , Lv Jian , Luo Sanzhong 
Published: January 2014

AbstractIt is demonstrated that the combination of In(OTf)3/benzoic acid efficiently catalyzes the coupling of alkynes and acetales to afford indanones in excellent yield and diastereoselectivity.
ChemInform Abstract: Synthesis of a trans‐Hydrindanone, Precursor for the Preparation of Vitamin D Analogues.
Authors: Gandara Zoila , Rivadulla Marcos L. , Perez Manuel , Gomez Generosa , Fall Yagamare 
Published: January 2014

AbstractA scalable synthesis of the title compounds is developed, based on the Criegee rearrangement.
ChemInform Abstract: Catalytic Asymmetric 1,3‐Dipolar Cycloadditions of Alkynes with Isatin‐Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline‐3,2′‐pyrrole] Derivatives.
Authors: Shi Feng , Zhu Ren‐Yi , Liang Xia , Tu Shu‐Jiang 
Published: January 2014

AbstractThe method represents the first enantioselective construction of spiro‐oxindole‐based 2,5‐dihydropyrrole compounds and the first enantioselective 1,3‐dipolar cycloaddition of alkynes with ketone‐derived azomethine ylides.
ChemInform Abstract: Dimerization of Cyclopropenes to Bifurans Using Tandem Metal Relay Catalysis.
Authors: Song Chuanling , Sun Di , Peng Xianglong , Bai Jing , Zhang Rongyi , Hou Shengzhen , Wang Jianwu , Xu Zhenghu 
Published: January 2014

AbstractA variety of substituted bifurans (II) (15 examples) is readily prepared by a palladium‐catalyzed dimerization of cyclopropenes (I).
ChemInform Abstract: A One‐Pot Coupling—Addition—Cyclocondensation Sequence (CACS) to 2‐Substituted 3‐Acylpyrroles Initiated by a Copper‐Free Alkynylation.
Authors: Nordmann Jan , Mueller Thomas J. J. 
Published: January 2014

AbstractA novel modular three‐component synthesis of title compounds (IV) and (VII) via sequential reaction of an acid chloride, an alkyne, and aminoacetaldehyde diethylacetal is reported.
ChemInform Abstract: Improved Catalyst‐Free Synthesis of Pyrrole Derivatives in Aqueous Media.
Authors: Tamaddon Fatemeh , Amirpoor Farideh 
Published: January 2014

AbstractThe novel procedure for the three component reaction of 1,3‐dicarbonyl compounds, α‐hydroxycarbonyl compounds, and ammonium acetate is less laborious and provides a better scope and chemoselectivity than previously reported procedures.
ChemInform Abstract: Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium‐Catalyzed Alkyne Cyclotrimerizations.
Authors: Foster Robert W. , Tame Christopher J. , Hailes Helen C. , Sheppard Tom D. 
Published: January 2014

AbstractA wide range of polysubstituted isoindolines is prepared mostly along with some amount of a homo‐coupled product.
ChemInform Abstract: Switchable Synthesis of 3‐Cyanoindoles and 3‐Amidylindoles via a Palladium‐Catalyzed Reaction of N,N‐Dimethyl‐2‐alkynylaniline with Isocyanide.
Authors: Qiu Guanyinsheng , Qiu Xiaochen , Liu Jianping , Wu Jie 
Published: January 2014

AbstractThe reaction of N,N‐dimethyl‐2‐alkynylanilines with isocyanides affords 3‐cyanoindoles [cf.
ChemInform Abstract: Synthesis of New Antifungal 1,2,4‐Bis‐oxadiazolines Using Cycloaddition Reaction of Nitrile Oxide with Bis‐Schiff Base.
Authors: Toumi Ahmed , Daami‐Remadi Mejda , Ben Jannet Hichem 
Published: January 2014

AbstractNew compounds (IIIb)—(IIIe) possess antifungal activities against B.
ChemInform Abstract: Dehydrogenative Heck Reaction (Fujiwara—Moritani Reaction) of Unactivated Olefins with Simple Dihydropyrans under Aprotic Conditions.
Authors: Pawar Govind Goroba , Singh Gaurav , Tiwari Virendra Kumar , Kapur Manmohan 
Published: January 2014

AbstractIn the reaction with olefins only (E)‐products are observed but in most of the cases along with some homo‐coupling products.
ChemInform Abstract: Synthesis of Polysubstituted Pyridines via Reactions of Chalcones and Malononitrile in Alcohols Using Amberlite IRA‐400 (OH‐).
Authors: Bahrami Kiumars , Khodaei Mohammad M. , Naali Fardin , Yousefi Behrooz H. 
Published: January 2014

AbstractPolysubstituted pyridine derivatives are synthesized through economical one‐pot multicomponent reactions of different α,β‐unsaturated ketones, malononitrile, and ethanol or methanol in the presence of Amberlite IRA‐400 (OH‐) as catalyst.
ChemInform Abstract: Conjugate Addition Reactions of N‐Carbamoyl‐4‐pyridones and 2,3‐Dihydropyridones with Grignard Reagents in the Absence of Cu(I) Salts.
Authors: Guo Fenghai , Dhakal Ramesh C. , Dieter R. Karl 
Published: January 2014

AbstractThe reactions proceed in the absence of any catalyst.
ChemInform Abstract: A Simple One‐Pot Procedure for the Synthesis of 1,2,4‐Triazolo[1,5‐a]pyridines via Pseudo Five‐Component Reactions Catalyzed by Molecular Iodine.
Authors: Alizadeh Abdolali , Saberi Vahid , Mokhtari Javad 
Published: January 2014

AbstractThe synthesis is advantageous with regards to mild reaction conditions, ease of purification, and ready availability of the starting materials.
ChemInform Abstract: 5,6,7,8‐Tetrahydropyrido[4,3‐c]pyridazine: A Lead‐Oriented Scaffold with Two Diversity Points.
Authors: Borisov Alexander V. , Voloshchuk Volodymyr V. , Nechayev Maxim A. , Grygorenko Oleksandr O. 
Published: January 2014

AbstractThe five step sequence for the synthesis of the title compounds includes the reaction of 4‐piperidone derivative (I) with glyoxylic acid and hydrazine as the key step.
ChemInform Abstract: A Facile and Practical Synthesis of Nicolaou′s Key Intermediates, 2‐Methyl‐ and 2,6‐Dimethyltetrahydropyrans, Toward the Total Synthesis of Ladder‐Shaped Polyethers.
Authors: Nakashima Takeharu , Baba Tomomi , Onoue Hisaaki , Yamashita Wataru , Torikai Kohei 
Published: January 2014

AbstractA rapid access to tetrahydropyrans (I) in only seven and eight steps starting from 2‐deoxy‐D‐ribose is described.
ChemInform Abstract: Synthesis and Broad Spectrum Antiviral Evaluation of bis(POM) Prodrugs of Novel Acyclic Nucleosides.
Authors: Agrofoglio Luigi A. , et al. et al. 
Published: January 2014

AbstractThe synthesis of a broad range of drugs bearing a (E)‐but‐2‐enyl aliphatic side chain is described including an olefin acyclic olefin cross metathesis as key step.
ChemInform Abstract: Efficient Copper‐Catalyzed Cross‐Coupling of 1‐Boc‐piperazine with Aryl Iodides and Its Application in the Synthesis of Trazodone.
Authors: Yong Fui‐Fong , Teo Yong‐Chua , Tan Khee‐Ngiap 
Published: January 2014

AbstractA convenient and practical strategy for the cross‐coupling of N‐Boc protected piperazines with aryl iodides in the presence of the catalytic system CuBr/rac‐BINOL is developed.
ChemInform Abstract: Ligand/PTC‐Free Intramolecular Heck Reaction: Synthesis of Pyrroloquinoxalines and Their Evaluation Against PDE4/Luciferase/Oral Cancer Cell Growth in vitro and Zebrafish in vivo.
Authors: Pal Manojit , et al. et al. 
Published: January 2014

AbstractNovel pyrroloquinoxalines (VIa), (VIc), and (VIg) show significant PDE4B inhibition and weak growth inhibition of oral cancer cell lines CAL 27, whilst the luciferase inhibition is low.
ChemInform Abstract: One‐Pot Microwave Assisted Synthesis of New 2‐Alkoxycarbonylmethylene‐4‐oxo‐1,5‐benzo‐, naphtho‐, and pyridodiazepines and Assessment of Their Cytogenetic Activity.
Authors: Eleftheriadis Nicolaos , Neochoritis Constantinos G. , Tsoleridis Constantinos A. , Stephanidou‐Stephanatou Julia , Iakovidou‐Kritsi Zafiroula 
Published: January 2014

AbstractThe synthesis of the title compounds and the evaluation of their in vitro cytogenic activity at typical concentration rates of the drug 1,4‐benzodiazepine is presented.
ChemInform Abstract: 8‐Functionalization of Alkyl‐Substituted‐3,8‐dimethyl BODIPYs by Knoevenagel Condensation.
Authors: Palao Eduardo , Agarrabeitia Antonia R. , Banuelos‐Prieto Jorge , Arbeloa Lopez Teresa , Lopez‐Arbeloa Inigo , Armesto Diego , Ortiz Maria J. 
Published: January 2014

AbstractIn contrast to previous studies Knoevenagel condensation reaction of methyl‐substituted BODIPYs provides the corresponding 8‐alkenyl derivatives.
ChemInform Abstract: Picazoplatin, an Azide‐Containing Platinum(II) Derivative for Target Analysis by Click Chemistry.
Authors: White Jonathan D. , Osborn Maire F. , Moghaddam Alan D. , Guzman Lindsay E. , Haley Michael M. , DeRose Victoria J. 
Published: January 2014

AbstractThe new title compound (I) readily binds DNA and RNA oligonucleotides and undergoes facile post‐labeling click reactions to alkyne—fluorophore conjugates.
ChemInform Abstract: Synthesis of 3′‐Azido‐2′,3′‐dideoxy‐5‐fluorouridine Phosphoramidates and Evaluation of Their Anticancer Activity.
Authors: Lewandowska Marta , Ruszkowski Piotr , Baraniak Dagmara , Czarnecka Anna , Kleczewska Natalia , Celewicz Lech 
Published: January 2014

AbstractThe precursor for the target compounds is prepared starting from 5‐fluoro‐2′‐deoxyuridine (I).
ChemInform Abstract: Ring‐Contraction vs Ring‐Expansion Reactions of Spiro‐Cyclopropanecarboxylated Sugars.
Authors: Ramakrishna Bandi , Sridhar Perali Ramu 
Published: January 2014

AbstractNIS‐Mediated ring‐opening of spirocyclopropane carboxylated sugars (I) produces α,β‐unsaturated esters (I) easily undergoing DBU‐mediated ring‐contraction to yield ketofuranoses (III)/(IV).
ChemInform Abstract: Oxidation Heck Reaction of Glycals and Aryl Hydrazines: A Palladium‐Catalyzed C‐Glycosylation.
Authors: Bai Yaguang , Kim Le Mai Hoang , Liao Hongze , Liu Xue‐Wei 
Published: January 2014

AbstractDepending on the C3 stereochemistry of the glycal substrate this method yields either diastereomerically pure products or mixtures of diastereomers.
ChemInform Abstract: The Exocyclic Olefin Geometry Control via Ireland—Claisen Rearrangement: Stereoselective Total Syntheses of Barmumycin (V) and Limazepine E (VI).
Authors: Smits Gints , Zemribo Ronalds 
Published: January 2014

AbstractThe highly selective Ireland—Claisen rearrangement of seven‐membered lactone‐derived boron enolate generated in situ is the key step to synthesize the naturally occurring antitumor agents (V) and (VI).
ChemInform Abstract: Negishi Cross‐Coupling Reaction as a Route to Isocombretastatins.
Authors: Malysheva Yulia B. , Buchvalova Svetlana Y. , Svirshchevskaya Elena V. , Fokin Valery V. , Fedorov Alexey Y. 
Published: January 2014

AbstractA new method based on Negishi cross‐coupling of alkenylzinc reagent (I) with aryl halides allows the synthesis of various Isocombretastatins.
ChemInform Abstract: Secondary Amines as Lewis Bases in Nitroalkene Activation
Authors: Yan Wuming , Shi Xiaodong , Zhong Cheng 
Published: January 2014

AbstractReview: systematic studies from the last five years on activation of nitroolefins with secondary amines as Lewis bases that give different multicomponent condensation products and asymmetric syntheses of heterocycles based on this strategy; 67 refs.
ChemInform Abstract: Recent Developments in the Ferrier Rearrangement
Authors: Gomez Ana M. , Lobo Fernando , Uriel Clara , Lopez J. Cristobal 
Published: January 2014

AbstractReview: recent developments in the use of promoters for the Ferrier rearrangement of O‐, N‐, C‐ and S‐nucleophiles with glycals; <250 refs.
ChemInform Abstract: N‐Heterocyclic Carbenes in Organofluorine Chemistry
Authors: Reddy V. Prakash , Vadapalli Avinash , Sinn Ekkehard , Hosmane Narayan 
Published: January 2014

AbstractReview: recent progress in organofluorinations catalyzed by N‐heterocyclic carbene‐transition metal ion complexes; 41 refs.
Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1‐Substituted Tetrahydroisoquinolines
Authors: Dohle Wolfgang , Leese Mathew P. , Jourdan Fabrice L. , Major Meriel R. , Bai Ruoli , Hamel Ernest , Ferrandis Eric , Kasprzyk Philip G. , Fiore Ann , Newman Simon P. , Purohit Atul , Potter Barry V. L. 
Published: January 2014

AbstractThe syntheses and antiproliferative activities of novel substituted tetrahydroisoquinoline derivatives and their sulfamates are discussed. Biasing of conformational populations through substitution on the tetrahydroisoquinoline core at C1 and C3 has a profound effect on the antiproliferative activity against various cancer cell lines. The C3 methyl‐substituted sulfamate (±)‐7‐methoxy‐2‐(3‐methoxybenzyl)‐3‐methyl‐6‐sulfamoyloxy‐1,2,3,4‐tetrahydroisoquinoline (6 b), for example, was found to be ∼10‐fold more potent than the corresponding non‐methylated compound 7‐methoxy‐2‐(3‐methoxybenzyl)‐6‐sulfamoyloxy‐1,2,3,4‐tetrahydroisoquinoline (4 b) against DU‐145 prostate cancer cells (GI50 values: 220 nM and 2.1 μM, respectively). Such compounds were also found to be active against a drug‐resistant MCF breast cancer cell line. The position and nature of substitution of the N‐benzyl group in the C3‐substituted series was found to have a significant effect on activity. Whereas C1 methylation has little effect on activity, introduction of C1 phenyl and C3‐gem‐dimethyl substituents greatly decreases antiproliferative activity. The ability of these compounds to inhibit microtubule polymerisation and to bind tubulin in a competitive manner versus colchicine confirms the mechanism of action. The therapeutic potential of a representative compound was confirmed in an in vivo multiple myeloma xenograft study.
Richardson–Lucy Deconvolution as a General Tool for Combining Images with Complementary Strengths
Authors: Ingaramo Maria , York Andrew G. , Hoogendoorn Eelco , Postma Marten , Shroff Hari , Patterson George H. 
Published: January 2014

AbstractWe use Richardson–Lucy (RL) deconvolution to combine multiple images of a simulated object into a single image in the context of modern fluorescence microscopy techniques. RL deconvolution can merge images with very different point‐spread functions, such as in multiview light‐sheet microscopes,1, 2 while preserving the best resolution information present in each image. We show that RL deconvolution is also easily applied to merge high‐resolution, high‐noise images with low‐resolution, low‐noise images, relevant when complementing conventional microscopy with localization microscopy. We also use RL deconvolution to merge images produced by different simulated illumination patterns, relevant to structured illumination microscopy (SIM)3, 4 and image scanning microscopy (ISM). The quality of our ISM reconstructions is at least as good as reconstructions using standard inversion algorithms for ISM data, but our method follows a simpler recipe that requires no mathematical insight. Finally, we apply RL deconvolution to merge a series of ten images with varying signal and resolution levels. This combination is relevant to gated stimulated‐emission depletion (STED) microscopy, and shows that merges of high‐quality images are possible even in cases for which a non‐iterative inversion algorithm is unknown.
Social aversive stimuli presented to the mother produce the precocious expression of fear in rat pups
Authors: Zuluaga María J. , Agrati Daniella , Uriarte Natalia , Ferreira Annabel 
Published: January 2014

ABSTRACTDuring the stress hypo‐responsive period, rat pups do not display fear responses toward adult males, yet they exhibit distress behavior in isolation. Since the mother modulates her offspring's affective development, we hypothesized that by altering the mother's behavior, a prolonged stressful situation would modify the ontogeny of the fear responses and distress behaviors in pups. Therefore, we repeatedly exposed the mother‐litter dyad to different socially stressful stimuli and subsequently evaluated in 8‐day‐old pups their fear responses toward an anesthetized male, as well as their distress behavior in isolation. Our results show that repeated exposure to unfamiliar males and females, which altered maternal behavior by eliciting aggression in the mother, was associated with the precocious fear responses in pups, though without altering their distress behavior in isolation. We propose that the mother, as the principal mediator of environmental influences, provokes the precocious expression of fear in pups through alterations in her maternal behavior. © 2014 Wiley Periodicals, Inc. Dev Psychobiol 56: 1187–1198, 2014.
Development of sexual behavior in free‐ranging female Japanese macaques
Authors: Leca Jean‐Baptiste , Gunst Noëlle , Vasey Paul L. 
Published: January 2014

ABSTRACTWe studied the development of sexual behaviors in female Japanese macaques (Macaca fuscata) living at Arashiyama, Japan, in a group where adult females routinely exhibit sexual interactions with both males and females. Our cross‐sectional data on juvenile, adolescent, and adult females supported most of our predictions related to the learning hypothesis, which holds that adolescence serves to provide females with a period in which to practice adult female‐like sexual behavioral patterns, including sexual solicitations, sexual mounts, and spatio‐temporal coordination during consortships. We found evidence for a gradual acquisition of adult‐like behavioral patterns (e.g., more frequent solicitations with body contact, more frequent complete mounts, more diverse solicitation patterns and complete mounting postures, and longer consortships involving prolonged inter‐mount grasping behavior between partners), and a gradual disappearance of less effective immature behavioral patterns (e.g., less frequent non‐contact solicitations, ambiguous mounting initiations, and incomplete mounts). We distinguished between three major categories of sexual behavioral patterns based on their speed of development, ranging from fast (e.g., diversity in mounting postures and genital stimulation during mounting) to slow (e.g., contact solicitations and grasping behavior between consortship partners), with some being intermediate (e.g., range of solicitation patterns and expression of complete mounts). This study showed that the emergence of both conceptive and non‐conceptive adult sexual behaviors can be traced back to immature behavioral patterns in adolescent female Japanese macaques, with a major threshold occurring at the age of 4 years. © 2014 Wiley Periodicals, Inc. Dev Psychobiol 56: 1199–1213, 2014.
Mandating weekly weight gain in a day treatment program for eating disorders
Authors: Thaler Lea , Wilson Samantha , Coelho Jennifer S. , Mazanek Antunes Juliana , Israel Mimi , Steiger Howard 
Published: January 2014

ABSTRACTObjectiveWe examined differences in treatment outcome associated with a “self‐directed”‐ versus “external‐incentive”‐based day treatment protocol for individuals with eating disorders (EDs) with below normal body mass index. The self‐directed protocol recommended a weekly 500 g weight gain, but allowed participants freedom to gain weight at their own rate; the “external‐incentive” protocol required a minimum weight gain of 500 g/week as a requirement for staying in the program.MethodWeight outcome was available for 49 individuals who were treated with the recommended weight gain protocol, and 40 individuals who were treated with the required weight gain protocol.ResultsPost‐treatment weight was significantly higher in patients treated in the required weight gain protocol compared to those treated in the recommended weight gain protocol. All patients, regardless of which program they completed, showed improvements in the measures of eating‐disorder and comorbid‐psychiatric symptoms.DiscussionThis study demonstrated the benefits of an alteration in protocol that required no additional financial or human resources. Further studies are needed to validate the effectiveness of various day treatment protocol parameters. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:500–506)
Do emotional eating urges regulate affect? Concurrent and prospective associations and implications for risk models of binge eating
Authors: Haedt‐Matt Alissa A. , Keel Pamela K. , Racine Sarah E. , Burt S. Alexandra , Hu Jean Yueqin , Boker Steven , Neale Michael , Klump Kelly L. 
Published: January 2014

ABSTRACTObjectiveEmotional eating (EE) reflects an urge to eat in response to emotional rather than physical cues and is a risk factor for the development of binge eating. EE has been conceptualized as an attempt to regulate negative affect (NA), a posited maintenance factor for binge eating. However, no study has examined whether EE urges regulate affect. Further, no studies have examined longitudinal associations between EE urges and positive affect (PA).MethodWe examined within‐subject longitudinal associations between affect and EE urges in a community‐based sample of female twins (mean age = 17.8 years). Participants (N = 239) completed ratings of affect and EE urges for 45 consecutive days.ResultsGreater NA was concurrently associated with greater EE urges. Additionally, greater EE urges predicted worse NA for both concurrent and prospective (next‐day) analyses. Finally, lower PA was associated with greater EE urges in concurrent analyses, but there were no prospective associations between changes in PA and EE urges.DiscussionEE urges do not appear to effectively regulate affect. EE urges in a community‐based sample appear to have the same functional relationship with affect as binge eating in clinical samples, further supporting EE as a useful dimensional construct for examining processes related to binge eating. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:874–877)