bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular treatment of contained ruptured internal thoracic artery aneurysm mimicking a tumor in a patient with neurofibromatosis type 1: a case report
Authors: Oda Ryoma , Endo Daisuke , Udagawa Takeshi , Okada Shingo , Kuwatsuru Ryohei , Tabata Minoru 
Published: August 2024

Abstract
Background
An internal thoracic artery aneurysm (ITAA) is an exceedingly rare condition, with approximately two-thirds of reported cases being iatrogenic pseudoaneurysms. The remainder are attributed to various causes, including vasculitis, connective tissue disease, and neurofibromatosis type 1 (NF-1). NF-1 is an autosomal dominant disorder characterized by distinct clinical manifestations that occasionally include life-threatening vascular complications. Although NF-1 patients may develop various vascular abnormalities, ruptured ITAA is rarely reported, with only seven published cases.

Case presentation
A 32-year-old man with NF-1 consulted for a three-day history of persistent left back and upper arm pain. Initial chest radiography indicated left pleural effusion and an opacity at the left lung apex. Computed tomography scan revealed a mass in the left upper mediastinum that was initially suspected to be a tumor. Subsequent contrast-enhanced computed tomography revealed the mass to be a subclavian artery aneurysm. Detailed contrast-enhanced computed tomography with 1-mm slices was performed for surgical planning, identifying the mass as a left ITAA with contained rupture. Given the risk of re-rupture, emergency angiography was performed, which confirmed rupture of the left ITAA without extravasation. The ITAA was successfully treated with multiple microcoils at the proximal and distal ends. The patient had an uneventful recovery and was discharged on the fourth postoperative day.

Conclusions
This case highlights the importance of considering vascular lesions in NF-1 patients who present with pleural effusion. It also emphasizes the challenges in diagnosing ITAA and the effectiveness of thin-slice contrast-enhanced computed tomography scans and endovascular treatment.
Surpass Evolve flow diverter in the treatment for complex wide neck ruptured internal carotid artery aneurysm: technical report of two cases with brief literature review
Authors: Karki Mohan , Rajpal Girish 
Published: August 2024

Abstract
Background
Treatment of complex wide neck internal carotid aneurysm is technically difficult with both surgical as well as endovascular therapy. In this study, we work with flow diverter device to construct vascular lumen which diverts the blood flow from aneurysm sac.

Case presentation
We report on two patients with two complex wide neck ruptured aneurysms located in the internal carotid artery associated with two small aneurysms who presented with severe headache and vomiting. All aneurysms were treated with single Surpass Evolve flow diverter (SE-FD) placement. Post-procedural clinical and angiographic outcomes were evaluated

Conclusion
This study shows that Surpass Evolve flow diverter is safe and validity for management of complex wide neck internal carotid artery aneurysm and able to terminate all blister aneurysms associated with the parent artery.
Understanding the interplay between dNTP metabolism and genome stability in cancer
Authors: Yagüe-Capilla Miriam , Rudd Sean G. 
Published: August 2024

ABSTRACT
The size and composition of the intracellular DNA precursor pool is integral to the maintenance of genome stability, and this relationship is fundamental to our understanding of cancer. Key aspects of carcinogenesis, including elevated mutation rates and induction of certain types of DNA damage in cancer cells, can be linked to disturbances in deoxynucleoside triphosphate (dNTP) pools. Furthermore, our approaches to treat cancer heavily exploit the metabolic interplay between the DNA and the dNTP pool, with a long-standing example being the use of antimetabolite-based cancer therapies, and this strategy continues to show promise with the development of new targeted therapies. In this Review, we compile the current knowledge on both the causes and consequences of dNTP pool perturbations in cancer cells, together with their impact on genome stability. We outline several outstanding questions remaining in the field, such as the role of dNTP catabolism in genome stability and the consequences of dNTP pool expansion. Importantly, we detail how our mechanistic understanding of these processes can be utilised with the aim of providing better informed treatment options to patients with cancer.
Biomechanical and morphological determinants of maximal jumping performance in callitrichine monkeys
Authors: Boulinguez-Ambroise Grégoire , Boyer Doug M. , Dunham Noah T. , Yapuncich Gabriel S. , Bradley-Cronkwright Madison , Zeininger Angel , Schmitt Daniel , Young Jesse W. 
Published: August 2024

ABSTRACT
Jumping is a crucial behavior in fitness-critical activities including locomotion, resource acquisition, courtship displays and predator avoidance. In primates, paleontological evidence suggests selection for enhanced jumping ability during their early evolution. However, our interpretation of the fossil record remains limited, as no studies have explicitly linked levels of jumping performance with interspecific skeletal variation. We used force platform analyses to generate biomechanical data on maximal jumping performance in three genera of callitrichine monkeys falling along a continuum of jumping propensity: Callimico (relatively high propensity jumper), Saguinus (intermediate jumping propensity) and Callithrix (relatively low propensity jumper). Individuals performed vertical jumps to perches of increasing height within a custom-built tower. We coupled performance data with high-resolution micro-CT data quantifying bony features thought to reflect jumping ability. Levels of maximal performance between species – e.g. maximal take-off velocity of the center of mass (CoM) – parallel established gradients of jumping propensity. Both biomechanical analysis of jumping performance determinants (e.g. CoM displacement, maximal force production and peak mechanical power during push-off) and multivariate analyses of bony hindlimb morphology highlight different mechanical strategies among taxa. For instance, Callimico, which has relatively long hindlimbs, followed a strategy of fully extending of the limbs to maximize CoM displacement – rather than force production – during push-off. In contrast, relatively shorter-limbed Callithrix depended mostly on relatively high push-off forces. Overall, these results suggest that leaping performance is at least partially associated with correlated anatomical and behavioral adaptations, suggesting the possibility of improving inferences about performance in the fossil record.
Ética no atendimento de enfermagem na unidade de terapia intensiva no contexto da pandemia pelo novo coronavírus
Authors: Silva Donizete Azevedo dos Santos , Borba Kátia Pereira de , Oliveira Bruna Eduarda Schreiner de , Daniella Machado Araújo Marília , Borba Evandro de 
Published: August 2024

Objetivo: Identificar a percepção da equipe de enfermagem atuante em uma unidade de terapia intensiva sobre as questões éticas que envolveram o atendimento de pessoas infectadas pelo Covid 19. Método: Estudo descritivo exploratório de abordagem qualitativa. Resultados: Participaram da pesquisa seis técnicas de enfermagem e uma enfermeira, na faixa etária 30 a 40 anos, com tempo de atuação superior a seis meses na UTI Covid. Entre as questões éticas percebidas pelo grupo investigado, a impotência e a tristeza por não conseguir salvar uma vida; medo de adquirir Covid 19 ao realizar o cuidado e por conseguinte transmitir aos familiares e a satisfação em reverter a doença dos acometidos pela gravidade da infecção, foram sentimentos exaltados. As situações vividas junto as famílias das vítimas pelo Covid 19, as quais desencadearam sintomas de ansiedade na equipe pesquisada, foram apontadas como dilemas éticos vivenciados. Destarte, a união da equipe, interdisciplinar e de enfermagem, pareceu ter contribuído beneficamente para o desenvolvimento do trabalho. Conclusão: As questões éticas percebidas pelas participantes no estudo envolveram a satisfação no sucesso do tratamento, e em grande proporção, o sentimento de impotência pelo agravamento e ou óbito das vítimas pelo Covid 19. Enaltecendo a grandeza das investigadas, reconhece-se um grupo imerso em um ambiente laboral envolvido em um processo de trabalho rico em superação de valores e princípios, e com potencialidade para a incorporação de novos valores e virtudes morais.
Ein Werkzeug zur Analyse von Komplexität von Low-Code und No-Code Add-ons: Ein Design Science Ansatz
Authors: Abendroth Adrian , Bender Benedict 
Published: August 2024

ZusammenfassungIn der schnelllebigen Geschäftswelt von heute ist es für Unternehmen entscheidend, sich rasch an veränderte Marktbedingungen anzupassen, um ihre Wettbewerbsfähigkeit zu sichern. Flexibilität und maßgeschneiderte Prozesse sind dabei zentrale Erfolgsfaktoren, die oft über die Möglichkeiten standardisierter Anwendungssysteme hinausgehen. Low-Code-Plattformen (LCP) wie Mendix und Outsystems sowie No-Code-Plattformen (NCP) wie Bubble bieten vielversprechende Ansätze zur Realisierung individueller Anpassungen durch visuelle und deklarative Techniken, die herkömmliche Programmierung ersetzen.Vor der Adoption einer solchen Plattform müssen Unternehmen beurteilen, wie gut eine spezifische LCP/NCP ihre individuellen Anforderungen erfüllen kann. Der mögliche Anforderungserfüllungsgrad hängt nicht nur von den Grundfunktionen einer Platform ab, sondern insbesondere von den verfügbaren Erweiterungen im Plattform-Ökosystem. Add-on-Stores bieten Zugang zu spezialisierten Erweiterungen, die die Grundfunktionen der Plattformen ergänzen und an spezifische Unternehmens-bedürfnisse anpassen können.Um die Eignung einer LCP/NCP für spezielle Anwendungsfälle zu bewerten, entwickelt dieser Beitrag ein Messinstrument zur Erfassung der Komplexität von Add-on-Stores unter Anwendung der Design Science Research Methode (DSR). Die Bewertung basiert auf der Analyse von 1483 Add-ons aus den Add-on-Stores von Microsoft Power Apps, Outsystems und Pega. Dieses Instrument ermöglicht es Unternehmen, die Vielfalt und Tiefe der verfügbaren Add-ons zu erfassen und somit fundierte Entscheidungen darüber zu treffen, ob eine LCP/NCP adoptiert werden soll. Dieser Beitrag unterstützt somit die Optimierung der Entscheidungsfindung bei der Auswahl von LCP/NCP.
Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes
Authors: Mia Md Mukthar , Allaie Idrees Mehraj , Zhang Xuejin , Li Kun , Khan Shahbaz M. , Kadotani Saki , Witola William H. 
Published: August 2024

Background
Filarial nematodes cause severe illnesses in humans and canines including limb deformities and disfigurement, heart failure, blindness, and death, among others. There are no vaccines, and current drugs against filarial nematodes infections have only modest effects and are prone to complications.

Methodology/principal findings
We identified a gene (herein called DiMT) encoding an S-adenosyl-L-methionine (SAM)-dependent methyltransferase with orthologs in parasite filarial worms but not in mammals. By in silico analysis, DiMT possesses catalytic sites for binding SAM and catecholamines with high affinity. We expressed and purified recombinant DiMT protein and used it as an enzyme in a series of SAM-dependent methylation assays. DiMT acted specifically as a catechol-O-methyltransferase (COMT), catalyzing catabolic methylation of dopamine, and depicted Michaelis Menten kinetics on substrate and co-substrate. Among a set of SAM-dependent methyltransferase inhibitors, we identified compounds that bound with high affinity to DiMT’s catalytic sites and inhibited its enzymatic activity. By testing the efficacy of DiMT inhibitors against microfilariae of Dirofilaria immitis in culture, we identified three inhibitors with concentration- and time-dependent effect of killing D. immitis microfilariae. Importantly, RNAi silencing of a DiMT ortholog in Caenorhabditis elegans has been shown to be lethal, likely as a result of excessive accumulation of active catecholamines that inhibit worm locomotion, pharyngeal pumping and fecundity.

Conclusions/significance
Together, we have unveiled DiMT as an essential COMT that is conserved in parasitic filarial nematodes, but is significantly different from mammalian COMTs and, therefore, is a viable target for development of novel drugs against filarial nematode infections.
Prognostic value of systemic inflammatory response index for acute kidney injury and the prognosis of pediatric patients in critical care units
Authors: Lu Danchi , Tu Lijuan , Hu Yugang , Cai Xiaofang 
Published: August 2024

Background
We proposed a link between the first systemic inflammatory response index (SIRI) and acute kidney injury (AKI), as well as the prognosis of pediatric patients in intensive care units (PICU).

Methods
This study comprised 5114 children from the pediatric-specific intensive care (PIC) database. SIRI was estimated as a neutrophil monocyte lymphocyte ratio. All patients were arbitrarily allocated to the training set (n = 3593) and the validation cohort (n = 1521) and divided into two groups depending on their SIRI levels. The diagnostic value of SIRI for pediatric ICU patients was subsequently determined using LASSO regression models.

Results
After controlling for additional confounding variables in the training set, the higher SIRI value (≥ 0.59) had a greater risk of AKI (adjusted odds ratio, OR, 3.95, 95% confidence interval, 95%CI, 2.91–5.36, P<0.001) and in-hospital mortality (hazard ratio, HR, 5.01, 95%CI 2.09–12.03, P<0.001). Similar findings were discovered in the validation set. Furthermore, the suggested nomogram derived from SIRI and other clinical metrics showed outstanding calibration capability as well as therapeutic usefulness in both groups.

Conclusions
SIRI is a reliable and useful factor for AKI and fatality in pediatric ICU patients, and the proposed nomogram based on SIRI yields an appropriate prediction value for critically sick pediatric patients.
Methodological rigor and quality of reporting of clinical trials published with physical activity interventions: A report from the Strengthening the Evidence in Exercise Sciences Initiative (SEES Initiative)
Authors: Conrado Ignacio Andresa , Oliveira Nórton Luís , Xavier Neves da Silva Larissa , Feter Jayne , De Nardi Angélica Trevisan , Helal Lucas , Rodrigues dos Santos Marcelo , Soares Douglas dos Santos , Morgana Galliano Leony , Alano Tainá Silveira , Umpierre Daniel 
Published: August 2024

Background
This study addresses the need for improved transparency and reproducibility in randomized clinical trials (RCTs) within the field of physical activity (PA) interventions. Despite efforts to promote these practices, there is limited evidence on the adherence to established reporting and methodological standards in published RCTs. The research, part of the Strengthening the Evidence in Exercise Sciences Initiative (SEES Initiative) in 2020, assessed the methodological standards and reporting quality of RCTs focusing on PA interventions.

Methods
RCTs of PA advice or exercise interventions published in 2020 were selected. Monthly searches were conducted on PubMed/MEDLINE targeting six top-tier exercise science journals. Assessments were conducted by two independent authors, based on 44 items originally from CONSORT and TIDieR reporting guidelines. These items were divided into seven domains: transparency, completeness, participants, intervention, rigor methodology, outcomes and critical analysis. Descriptive analysis was performed using absolute and relative frequencies, and exploratory analysis was done by comparing proportions using the χ2 test (α = 0.05).

Results
Out of 1,766 RCTs evaluated for eligibility, 53 were included. The median adherence to recommended items across the studies was 30 (18–44) items in individual assessments. Notably, items demonstrating full adherence were related to intervention description, justification, outcome measurement, effect sizes, and statistical analysis. Conversely, the least reported item pertained to mentioning unplanned modifications during trials, appearing in only 11.3% of studies. Among the 53 RCTs, 67.9% reported having a registration, and these registered studies showed higher adherence to assessed items compared to non-registered ones.

Conclusions
In summary, while critical analysis aspects were more comprehensively described, aspects associated with transparency, such as protocol registrations/modifications and intervention descriptions, were reported suboptimally. The findings underscore the importance of promoting resources related to reporting quality and transparent research practices for investigators and editors in the exercise sciences discipline.
Karakteristik Klinis dan Faktor-faktor yang Berpengaruh pada Luaran Pasien di Unit Perawatan Intensif Anak Level Sekunder di Rumah Sakit Umum Daerah Tipe B
Authors: Angelina Angelina , Aviana Ruthie , Ardelia Yolanda , Dewi Arfianti Chandra 
Published: August 2024

Latar belakang. Setiap unit perawatan intensif anak (UPIA) memiliki karakteristik berbeda dan evaluasi terhadap luaran pasien penting untuk memperbaiki kualitas pelayanan. Data publikasi penelitian terkait UPIA umumnya dikerjakan pada level tersier.Tujuan Mengetahui karakteristik klinis, luaran, serta faktor-faktor yang memengaruhi luaran di UPIA level sekunder pada Rumah Sakit Umum Daerah (RSUD).Metode: Penelitian potong lintang retrospektif menggunakan data rekam medis pasien yang dirawat di UPIA RSUD Balaraja selama tahun 2022. Data yang diambil mencakup data demografis (usia, jenis kelamin, berat badan), ruang asal perawatan, diagnosis utama, komorbiditas, terapi selama perawatan, dan parameter laboratorium. Hasil uji statistik disajikan dalam nilai p serta interval kepercayaan 95%, besarnya hubungan dinyatakan dengan nilai odd ratio (OR).Hasil: Seratus satu pasien masuk dalam penelitian. Sebagian besar berusia di bawah 1 tahun, berasal dari bangsal perawatan, dan memiliki komorbiditas. Sebanyak 87,1% pasien memiliki diagnosis utama medis, pneumonia dan infeksi sistem saraf pusat merupakan diagnosis terbanyak. Terdapat 32 pasien (31,6 %) meninggal dunia, penggunaan ventilator mekanik (OR 36,75; 95% KI 8,014-168,519; p<0,001) dan pemberian obat vasoaktif (OR 11; 95% KI 4,137-29,295; p<0,001) berhubungan bermakna dengan tingkat mortalitas. Kesimpulan: Sebagian besar pasien adalah bayi yang didominasi dengan masalah medis akibat infeksi. Tingkat mortalitas cukup tinggi, berhubungan bermakna dengan penggunaan ventilator mekanik invasif serta obat vasoaktif.
Forest Plundering in the Forest Management Unit (KPH) Randublatung, Blora Regency: Types of Plundering and the Involvement of External Community Actors
Authors: Ulyatin Nazal Chilmi , Sulistiyono Singgih Tri , Rochwulaningsih Yety 
Published: August 2024

This study examines forest plundering in KPH Randublatung involving individuals from outside the forest communities. The Reformation era marked the beginning of numerous demonstrations in both urban and rural areas across various regions. In forest villages where communities have close geographical proximity to state forests, one form of particularly intense demonstration was forest plundering. As residents of forest villages, or communities living near KPH, they have engaged in the practice of mblandongeven since the colonial period. Acts of taking wood from state forests have occurred for a long time. However, in the lead-up to the Reformation, taking wood from the forest evolved beyond mere theft, escalating into acts of plundering. This study analyzes the factors driving forest plundering, which also involved parties from outside the forest villages. The research findings indicate both internal (village community) and external factors contributing to the plundering. Internal factors include community customs, perceptions, and the necessity for survival amidst an environment that does not guarantee livelihood sustainability. External factors include political instability in the lead-up to the Reformation, which created opportunities for plunderers due to the absence of legal certainty. Additionally, the emergence of financiers driven by the demand for teak wood in the market also fueled organized and structured plundering. These actions were often supported by security forces.
On Reducing Space Amplification with Multi-Column Compaction in Apache IoTDB
Authors: Fang Chenguang , Chen Zijie , Song Shaoxu , Huang Xiangdong , Wang Chen , Wang Jianmin 
Published: August 2024

Log-structured merge trees (LSM-trees) are commonly employed as the storage engines for write-intensive workloads in modern time series databases including Apache IoTDB. Following append-only principle, LSM-trees can handle intensive writes and updates, but consequently suffer high space amplification (SA). To reduce SA in LSM-tree, compaction is triggered periodically to reorganize a large number of immutable files on disk to eliminate redundancy. This issue is further complicated in the Internet of Things (IoT) scenarios, where frequent out-of-order data insertions and data updates introduce duplicated keys, obsolete values and overlapping bitmaps in multi-column data, thereby exacerbating SA concerns.
To mitigate SA in such contexts, this paper presents a Multi-Column Compaction (MCC) strategy in Apache IoTDB, an open-source time series database utilizing LSM-tree architecture and supporting multi-column storage. We take into consideration both the separate insertions (out-of-order data) and updates of multi-column data, and analyze the hardness of selecting proper files with the maximum space reduction in compaction. We then propose a heuristic method designed to improve the file selection, thus reducing SA. To enhance the efficiency of this approach, we further devise File Prefetcher and Compaction Cache. The proposed MCC has been implemented in Apache IoTDB. Experimental results demonstrate that our proposed MCC achieves better performance in reducing space amplification.
AutoTSAD: Unsupervised Holistic Anomaly Detection for Time Series Data
Authors: Schmidl Sebastian , Naumann Felix , Papenbrock Thorsten 
Published: August 2024

Detecting anomalous subsequences in time series data is one of the key tasks in time series analytics, having applications in environmental monitoring, preventive healthcare, predictive maintenance, and many further areas. Data scientists have developed various anomaly detection algorithms with individual strengths, such as the ability to detect repeating anomalies, anomalies in non-periodic time series, or anomalies with varying lengths. For a given dataset and task, the best algorithm with a suitable parameterization and, in some cases, sufficient training data, usually solves the anomaly detection problem well. However, given the high number of existing algorithms, their numerous parameters, and a pervasive lack of training data and domain knowledge, effective anomaly detection is still a complex task that heavily relies on manual experimentation.
We propose the unsupervised AutoTSAD system, which parameterizes, executes, and ensembles various highly effective anomaly detection algorithms. The ensembling system automatically presents an aggregated anomaly scoring for an arbitrary time series without a need for training data or parameter expertise. Our experiments show that AutoTSAD offers an anomaly detection accuracy comparable to the best manually optimized anomaly detection algorithms, and can significantly outperform existing method selection and ensembling approaches for time series anomaly detection.