bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’immunocytokine FAP-IL2v: Un co-traitement efficace pour pallier la résistance au trastuzumab du cancer du sein HER2+
Authors: Parisel Eléonore , Prudhomme Laura , Pol Jonathan 
Published: July 2024

Dans le cadre de leur module d’analyse scientifique, des étudiants des promotions 2022-2023 et 2023-2024 des Master 2 « Immunologie Translationnelle et Biothérapies » (ITB) et « Immunologie Intégrative et Systémique » (I2S) (Mention Biologie Moléculaire et Cellulaire, Parcours Immunologie, Sorbonne Université) se sont penchés sur la littérature et ont pris la plume pour partager avec les lecteurs de m/s quelques-uns des faits marquants de l’actualité en immunologie. Voici une sélection de quelques-unes de ces nouvelles, illustrant la large palette des axes de recherche en cours sur les mécanismes physiopathologiques des maladies infectieuses, auto-immunes, inflammatoires et tumorales et sur le développement d’immunothérapies pour le traitement de ces pathologies.
On y découvre ainsi de nouvelles avancées sur l’analyse transcriptomique du microenvironnement inflammatoire de pathologies autoimmunes, sur des aspects mécanistiques impliqués dans la survie des cellules cancéreuses et la réponse immunitaire anti-tumorale des cellules NK, l’interconnexion entre le système immunitaire et le système nerveux périphérique, le développement de nouvelles immunothérapies permettant de cibler préférentiellement le microenvironnement tumoral et la prise en charge des effets secondaires autoimmuns cardiaques induits par les immunothérapies.
Toute l’équipe pédagogique remercie également chaleureusement les différents tuteurs, experts dans le domaine en lien avec les nouvelles, qui ont accompagné avec bienveillance et enthousiasme le travail de nos étudiants !
Journey to the Centre of the Ovale: A Novel, Combined Percutaneous Fluoroscopic and Image-Guided Approach to Biopsy a Meckel's Cave Lesion
Authors: Khan Amad , Anwar Durria , Hempenstall Jonathan , Vajramani Girish 
Published: July 2024

Abstract
Introduction The percutaneous Hartel's technique is a well-described approach to targeting lesions in the Meckel's cave. It is used as the standard approach for all percutaneous trigeminal neuralgia procedures for accessing the Gasserian ganglion through the foramen ovale, be it for a balloon compression, glycerol rhizolysis, or radiofrequency ablation. It has also been described in the literature as an approach to biopsy lesions in the Meckel's cave and cavernous sinus using fluoroscopic guidance; however, there were a significant number of nondiagnostic samples. No one to date has described a combined fluoroscopic and image-guided approach to improve safety and accuracy.
Methods The patient had a 3-month history of left-sided facial numbness and a left VIth palsy causing diplopia and a squint. The computed tomography of the chest, abdomen, and pelvis was unremarkable as were the serum tumor markers. We describe the novel approach of using a percutaneous biopsy needle to obtain a cytological sample of a Meckel's cave lesion using a combination of X-ray and electromagnetic image guidance with use of StealthStation S8 System (Medtronic Sofamor Danek, Memphis, Tennessee, United States). The need for a craniotomy and its associated morbidity and technical challenges was therefore obviated.
Results The procedure was performed under general anesthesia and eight core samples were sent to neuropathology for analysis. The lesion was histologically confirmed to be lymphoma, and the patient subsequently received oncological treatment. The patient had no immediate or postoperative complications, and the use of the aforementioned combined approach improved safety and accuracy of targeting the lesion in real time.
Conclusion A combined percutaneous fluoroscopic and image-guided approach to biopsy a Meckel's cave lesion is recommended, as it improves safety and accuracy.
Safety and Efficacy of Lipiodol and N-Butyl Cyanoacrylate (N-BCA) Combination for Vascular Embolization
Authors: Prasad Raghunandan , Marotrao Pole Shivaji , Sheorain Virender Singh , Gamanagatti Shivanand 
Published: July 2024

Abstract
Purpose The aim of this study was to evaluate the safety and efficacy of the combination of Lipiodol and N-butyl cyanoacrylate (N-BCA) for vascular embolization.
Methods Patients with various vascular pathologies, eligible for embolization using a combination of Lipiodol and N-BCA, were included in this ethical committee–approved prospective multicenter study. Adverse events (AEs) during the procedure and up to 30 days were recorded and categorized into minor or major (AE classification by the Society of Interventional Radiology). Depending on the targeted volume of vascular occlusion of the lesion, lesions were classified into four groups (group 1: <50% target volume; group 2: 50–75%; group 3: 75–99%, and group 4: 100%). Consistency between the targeted and actual vascular occlusion achieved after embolization was assessed.
Results One hundred and twenty-four patients were enrolled. All underwent at least one procedure, and 12 required a second procedure. No AEs were noted during the procedure, while 42 AEs occurred in 23 patients (18.5%) after and during the follow-up period. Two minor AEs in one patient (0.8%) were related to the mixture, and 26 AEs in 16 patients (12.9%) were related to the procedure (mostly minor A, 30.8% or B, 42.3%). The most frequent procedure-related AE was postembolization syndrome (4.8%). Nonfatal serious AEs related to the procedure occurred in two patients. The actual vascular occlusion was equal to or greater than the targeted volume in 119/135 lesions (88.1%) following the first procedure and in 11/13 lesions (84.6%) following the second procedure.
Conclusion Lipiodol and N-BCA combination is safe and highly effective for vascular embolization.
Success of Combination Therapy with Isavuconazole in a Pediatric Patient with Breakthrough Invasive Aspergillosis
Authors: Özen Seval , Yildiz Selin , Keçeli Avni Merter , Kanik-Yüksek Saliha , Güzelküçük Zeliha , Uzuntaş Sema Turan , Gülhan Belgin , Şahin Elif Ayça , Parlakay Aslı Nur Özkaya , Yarali Neşe 
Published: July 2024

AbstractThe increasing incidence of invasive fungal infections, coupled with the growing population of immunocompromised patients, has led to an increased need for antifungal agents. The newest azole, isavuconazole, plays an important role in the treatment of invasive aspergillosis in adults due to its broad spectrum, tolerability, and no need for therapeutic drug monitoring. This agent, which has not yet been approved for use in children, has significant problems with drug supply in Türkiye. We present the treatment response to isavuconazole combination therapy used in salvage treatment in a patient with breakthrough invasive aspergillosis, who had treatment failure with different antifungal combination treatment options and surgical resection.
Density functional theory study of the adsorption and dissociation of OF2 and O3 gases on the surface of pristine and Al, Ti and Cr doped graphene
Authors: Talha Abu , Shihab Fatin Hasnat , Ahmed Mohammad Tanvir , Al Roman Abdullah , Kowser Zannatul , Roy Debashis 
Published: July 2024

In this research, we studied pristine (PGs) and Al, Ti, and Cr-doped graphene (DGs) via density functional theory calculations for adsorption of OF2 and O3 gas. Changes in the structural, electronic, and optical properties due to Al, Ti, and Cr-doping as well as gas adsorption have been studied. After doping with Al, Ti, and Cr atoms, the cohesive energies were −8.787, −8.754, and −8.768 eV, respectively, where the negative values indicate the structural stability of doped sheets. The OF2 adsorbed on the complexes of PGs, Ti-DGs, Cr-DGs, and Al-DGs showed strong adsorbate–adsorbent interaction with −0.468, −16.369, −11.096, and −9.158 eV adsorption energies, respectively. Similarly, for O3 gas, the adsorption energies of those sheets are −0.444, −10.575, −10.870, and −6.711 eV, respectively. From optical properties analysis, we found that the maximum reflectivity for gas-adsorbed Ti-DGs and Cr-DGs is found in the UV region, whereas the highest reflectivity for Ti-DGs and Cr-DGs is found in the visible range. Our studies reveal that all these DGs are good candidates for the adsorption and dissociation of OF2 and O3 gases.
A community proactive health management model for family doctors in Shandong, China
Authors: Yang Meng 
Published: July 2024

Background Chronic disease management is an essential part of public health management and a fundamental means of slowing down the progression of major diseases. Unlike traditional medical care, proactive health management focuses on the combination of prevention and treatment. Proactive health management can reduce the re-admission rate of patients with chronic diseases, improve long-term prognosis, and effectively reduce the disability and mortality rates of major health events. This study aimed to establish a proactive health management model based on a grid-based medical service team arrangement, and to explore the effect of this model on managing chronic diseases in community health service institutions. Methods A grid-based medical service team was established in Binzhou, Shandong, China, consisting of general practitioners, nurses, public health doctors, health promoters and community grid liaison staff. Each team was responsible for several areas to monitor critical populations within the grid and compile statistics on the health management of these key populations in 2022–2023. Results A total of 2050 patients with coronary artery disease, 4973 patients with hypertension, and 1621 patients with type 2 diabetes were followed up in 2022. Compared with 155,612 resident health records in 2022, the number of records increased by 140.50% in 2023. The number of patients with hypertension under health management in 2023 increased by 50.92%; patients with type 2 diabetes increased by 74.65%; and the number of coronary artery disease increased by 42.00%. After the implementation of grid management, the hospitalisation rate for patients with type 2 diabetes significantly decreased in 2023 (P < 0.05). However, the hospitalisation rate for patients with coronary artery disease and hypertension was similar in 2023 to that in 2022 (P > 0.05). Conclusion The grid-based community proactive health management model makes full use of the advantages of community resources and improves the pertinence and coverage of community health services. Moreover, it reduces hospitalisation for patients with type 2 diabetes.
First and second person forms as resources for open reference and participation in Finnish everyday
conversations
Authors: Helasvuo Marja-Liisa , Suomalainen Karita 
Published: July 2024

Abstract
Based on data from Finnish conversational interaction, this article explores the use of 1st and 2nd person
forms in creating deictically non-specific, open reference. We focus on the linguistic and embodied features of turns that
contain these open personal forms and examine their sequential positioning. We show that the 1st and 2nd person forms that
receive a deictically open interpretation typically occur in assessments, accounts of personal experience, and imaginary
descriptions. They function as deictic displacements, shifting the origo of the speech situation, and causing a change of
footing in the discourse roles, thus modulating the participation framework of the speech situation.
A - 18 Sport Concussion Assessment Tool-5th Edition (SCAT5) Normative Reference Values for Professional Men’s Rugby League Players
Authors: Maietta J E , Terry D A , Lakisa D R , Iverson G L , Gardner A J 
Published: July 2024

Abstract

Purpose
The Sport Concussion Assessment Tool-5th Edition (SCAT5) is a standardized assessment that is administered to athletes at preseason and after suspected concussion. We provide normative reference values for men’s professional National Rugby League (NRL) players.

Method
Baseline SCAT5 scores were obtained from 1005 NRL players during the 2018 and 2019 seasons (Mage = 25.9). Players self-identified whether they considered their cultural heritage or ethnicity to be “Pasifika (Pacific Islander) or Māori” (n = 243; 24.2%) or “Indigenous Australian” (n = 82; 8.2%). Those who identified as being from any other race, ethnicity, or cultural heritage were combined into a single group (n = 680; 67.7%). We provide normative values for the Standardized Assessment of Concussion (SAC), Symptom Evaluation (i.e., symptom severity and symptom number), and the Modified Balance Error Scoring System (mBESS).

Results
There were no significant differences between the cultural heritage or ethnicity groups for SAC total scores, symptom severity or number, or mBESS errors (p’s &gt; 0.05). The median SAC score was 27 (IQR = 25–28), median symptom severity was 0 (IQR = 0–2), median symptom number was 0 (IQR = 0–1), and median mBESS error score was 3 (IQR = 1–5). SAC scores of &lt;23 and mBESS errors &gt;7 were uncommon in the sample while SAC scores of 26–30 and mBESS scores of 0–4 were considered within normal expectations (WNE). Reporting &gt;4/22 symptoms and &gt; 6/132 severity was uncommon while 0–1 symptoms and 0–1 symptom severity was WNE.

Conclusions
Normative reference values for the SCAT5 are provided for a sample of elite professional men’s rugby league players from Australia.
A - 29 Clinical Considerations for Concussion Care for Transgender Youth
Authors: Datoc A E , Mathew A S , Boucher S J , Choi D M , Ellis C , Abt J P 
Published: July 2024

Abstract

Purpose
Medical care for transgender youth requires a tailored approach to address their specific healthcare needs. The purpose of this study was to compare concussion patient characteristics between a population of youth who identified as transgender and their cisgender peers.

Method
Data were extracted from medical records (neurodevelopmental/psychiatric history, mechanism of injury, time between injury/evaluation, time between evaluation/recovery, and initial PCSS score) of 10 female patients selected using a stratified random sampling method (Mage = 15.0¬ ± 2.9 years) and five patients who identified as transgender with female sex assigned at birth (Mage = 14.4¬ ± 1.5 years). All patients presented to a specialty concussion clinic in 2020–2023.

Results
Patients who identified as transgender were significantly more likely to have a history of anxiety (X2[1] = 8.57, p = 0.003) and depression (X2[1] = 10.91, p &lt; 0.001). Recovery time was significantly longer in those who identified as transgender (Mtrans = 36¬ ± 20.6 days; Mcis = 18.9¬ ± 8.6 days; p = 0.03). Days since injury to initial visit (Mtrans = 6.4¬ ± 2.4 days; Mcis = 3.8¬ ± 3.5 days; p = 0.16) and PCSS score (Mtrans = 46.8¬ ± 16.5; Mcis = 38¬ ± 26.6; p = 0.56) did not differ between groups.

Conclusions
The average recovery time for this sample of transgender youth was significantly longer than their cisgender peers. Transgender youth also reported higher rates of anxiety and depression, which are well-known to impact concussion recovery. Sensitivity to psychological distress and mental health history is crucial for overall medical care and is supported when assessing and treating concussion in transgender youth. The effects of gender transition-related treatments (i.e., hormone therapy), discomfort in gender-segregated spaces, gender dysphoria, and other minority stressors warrant further research and should also be considered in concussion care of transgender patients.
A - 30 Head-Injury Exposure and Later-in-Life Cognitive and Psychiatric Outcomes among Former Collegiate Football Players
Authors: Datoc A E , Schaffert J , Didehbani N , Doggett H , LoBue C , Cullum C M 
Published: July 2024

Abstract

Purpose
Current understanding of potential long-term negative cognitive and psychiatric outcomes following head-injury exposure is limited, and this study aimed to evaluate these relationships in former collegiate football players.

Method
Former collegiate football players completed the College Level Aging Athlete Study (CLEAATS) survey including playing career, concussion/medical/psychiatric history, self-reported cognitive functioning, and measures of depression, anxiety symptoms, positive affect/resilience, emotional dysregulation, and objective cognitive function. A head-injury exposure estimate (HIEE, modified from Kerr et al., 2015) was calculated to determine total sports-related head-injury exposure. Partial correlations (controlling for age and education) examined the relationship between HIEE and cognitive functioning and emotional/mood symptoms.

Results
Participants (n = 216) were 50–87 years old (M = 63.4 [8.5]), 91% White, and well-educated (bachelor’s or graduate degree = 92%). HIEE (M = 763.8 [342.9]) was not correlated with any cognitive or emotional/mood symptom measures (p’s &gt; 0.075). Depression (r = 0.65), anxiety (r = 0.48), and emotional dysregulation indices (r = 0.50) showed moderate positive correlations with subjective cognitive symptoms. Grit (r = −0.36) and positive affect/well-being (r = −0.49) were negatively correlated with cognitive symptom reporting.

Conclusions
HIEE was not found to be related to cognitive or emotional/mood outcomes, and results suggest that current emotional/mood symptoms have greater associations with subjective cognitive symptoms. Alternatively, positive affect/resilience were found to be negatively associated with cognitive symptoms, and may serve as protective factors against cognitive complaints. These findings are consistent with previous studies that have reported associations between cognitive symptoms, psychological distress, and resilience in former athletes, highlighting the importance of considering potential impact of current emotional/mood symptoms when evaluating retired players with cognitive concerns.
A - 45 Rasch Analysis of the Brief Resilience Scale in Adolescents with Sports-Related Concussion
Authors: Sanders G D , Hynan L S , Bunt S C , Cullum C M 
Published: July 2024

Abstract

Purpose
Accurate measurement of latent abilities is essential for valid inference. The Brief Resilience Scale (BRS) assesses the “ability to bounce back”from stressful situations, and resilience may play a role in concussion recovery. Questions regarding the factor structure of the BRS have been explored in other populations, but evidence of its measurement quality in concussion is lacking. The present study investigated the psychometric properties of the BRS in concussed adolescents within a Rasch framework.

Method
927 participants aged 12 to 18 (M = 14.7; 50.3% female) underwent clinical evaluation within 30 days of injury in the ConTex study. The BRS contains 6 items rated on a 5-point Likert scale (Strongly Disagree to Strongly Agree), half of which are reverse scored. The Rasch Rating Scale Model was applied and item fit statistics and dimensionality were examined to assess the degree of fit of the data to the Rasch model.

Results
Item difficulties ranged −0.82 to 0.77. Item fit was adequate based on mean-square infit and outfit values. The BRS demonstrated sufficient targeting except for participants at the highest and lowest range of latent ability. Unidimensionality testing indicated the presence of a secondary dimension.

Conclusions
The BRS showed suboptimal fit with the Rasch model based on lack of unidimensionality. However, violations likely reflect item wording effects and not a substantive dimension that merits scale modification. Application of Rasch and other item response theory methodologies can enable development of more psychometrically sound and clinically informative tools for use in the context of concussion outcomes.
A - 46 Putting Together “Puzzle Pieces” of the Game: Executive Functions in Athletes with Sports-Related Concussion History
Authors: Doucette M M , Garcia-Barrera M A 
Published: July 2024

Abstract

Purpose
While previous quantitative research has explored the malleability of executive functions in sports, there’s a gap in understanding athletes’ descriptions and utilization of executive functions during gameplay. Understanding these processes from athletes’ perspectives is crucial for developing relevant assessments, particularly following sports-related concussion (SRC), as well as using accessible athlete-driven language to describing executive function in sports neuropsychology. Thus, our study aimed to explore how athletes deploy executive functions during games and identify the most crucial executive function components for success.

Method
19 Canadian collegiate athletes (ages 18–25; 37% female) with a history of SRC across various sports (soccer, volleyball, rugby, and basketball) were recruited. Participants completed semi-structured interviews via Zoom with a focus on identifying their executive function processes in their respective sports. Thematic analysis, following Braun and Clarke’s (2006) approach, was used to analyze the interview transcripts.

Results
We generated three themes: 1) Planning, organizing, and deciding action before actively involved in the play; 2) Problem solving when the contingencies for the pre-planned play changes; 3) Processing and evaluating performance immediately after a play.

Conclusions
These results provide nuance to our understanding of executive functions in sport by gaining insight into how athletes think while playing, information that neither tasks nor questionnaires offer. Through qualitative interviews, we discovered athletes engage in various executive processes throughout the game, including strategic planning and problem-solving. Overall, this study highlights specific executive processes employed throughout a game, which may become areas of focus for assessment, interventions, and follow-up for athletes following SRC.
A - 48 Predictors of Prolonged Recovery after Concussion in Collegiate Athletes: a LIMBIC MATARS Consortium Investigation
Authors: Smetana R M , Broshek D K , Rosenblum D J , Resch J E 
Published: July 2024

Abstract

Purpose
To investigate predictors of prolonged recovery after concussion in collegiate athletes.

Method
Data for this cross-sectional, retrospective chart review of collegiate athletes diagnosed with concussion (n = 1044 concussions), who were on average 20-years of age, were collected during the 2015–16 to 2019–20 athletic seasons. The majority (92% [959/1044]) of athletes achieved symptom resolution at rest and made an unrestricted return-to-sport by 23 days after injury. The remaining athletes (8% n = 85[36.5% female]), with symptoms that lasted beyond 23 days after concussion were considered to have prolonged recovery. Linear regression was used to determine predictors of prolonged recovery; times to symptom-freedom and unrestricted return-to-sport were dependent variables and variables associated with medical and psychiatric history, and some post-concussion symptoms, were independent variables.

Results
Athletes with prolonged recovery generally recovered on median (interquartile range) 32 (17) days after injury. The majority (42% [36/84]) participated in football. A self-reported history of anxiety [Β = 0.577, p = 0.01], depression [Β = 0.462, p = 0.04], a history of headache [Β = 0.84, p &lt; 0.001], and migraine [Β = 0.761, p &lt; 0.001] were predictors of prolonged recovery. A history of prior concussion and higher symptom burden immediately after concussion did not predict prolonged recovery (all p &gt; 0.05).

Conclusions
Similar to related research, our findings suggest a self-reported history of psychiatric conditions, headache, and migraine associate with prolonged recovery in collegiate athletes. Our findings highlight the importance of mood symptom monitoring, early psychological intervention, and management of headache following concussion. Importantly, the majority of our sample, inclusive of collegiate athletes with prolonged recovery, recovered approximately one-month after injury.