bluuebunny/crossref_metadata_2025_split huggingface dataset:
Front-Line Transplantation Program With Lenalidomide, Bortezomib, and Dexamethasone Combination As Induction and Consolidation Followed by Lenalidomide Maintenance in Patients With Multiple Myeloma: A Phase II Study by the Intergroupe Francophone du Myélome
Authors: Roussel Murielle , Lauwers-Cances Valérie , Robillard Nelly , Hulin Cyrille , Leleu Xavier , Benboubker Lotfi , Marit Gérald , Moreau Philippe , Pegourie Brigitte , Caillot Denis , Fruchart Christophe , Stoppa Anne-Marie , Gentil Catherine , Wuilleme Soraya , Huynh Anne , Hebraud Benjamin , Corre Jill , Chretien Marie-Lorraine , Facon Thierry , Avet-Loiseau Hervé , Attal Michel 
Published: July 2014

Purpose The three-drug combination of lenalidomide, bortezomib, and dexamethasone (RVD) has shown significant efficacy in multiple myeloma (MM). The Intergroupe Francophone du Myélome (IFM) decided to evaluate RVD induction and consolidation therapies in a sequential intensive strategy for previously untreated transplantation-eligible patients with MM. Patients and Methods In this phase II study, 31 symptomatic patients age < 65 years were enrolled to receive three RVD induction cycles followed by cyclophosphamide harvest and transplantation. Patients subsequently received two RVD consolidation cycles and 1-year lenalidomide maintenance. Results Very good partial response rate or better at the completion of induction, transplantation, and consolidation therapy was 58%, 70%, and 87%, respectively. Maintenance upgraded responses in 27% of patients. Overall, 58% of patients achieved complete response, and 68% were minimal residual disease (MRD) negative by flow cytometry. The most common toxicities with RVD were neurologic and hematologic, including grade 1 to 2 sensory neuropathy (55%), grade 3 to 4 neutropenia (35%), and thrombocytopenia (13%). Two basal cell carcinomas in the same patient and one case of breast cancer were observed. There was no treatment-related mortality. With a median follow-up of 39 months, estimated 3-year progression-free and overall survival were 77% and 100%, respectively. None of the patients who achieved MRD negativity relapsed. Conclusion The transplantation program with RVD induction and consolidation followed by lenalidomide maintenance produced high-quality responses and showed favorable tolerability in patients with newly diagnosed MM. Overall, 68% of patients achieved MRD negativity; none of these patients relapsed. This program is being evaluated in the ongoing IFM/Dana-Farber Cancer Institute 2009 phase III study.
shRNA-seq data analysis with edgeR
Authors: Dai Zhiyin , Sheridan Julie M. , Gearing Linden J. , Moore Darcy L. , Su Shian , Dickins Ross A. , Blewitt Marnie E. , Ritchie Matthew E. 
Published: July 2014

Pooled short hairpin RNA sequencing (shRNA-seq) screens are becoming increasingly popular in functional genomics research, and there is a need to establish optimal analysis tools to handle such data. Our open-source shRNA processing pipeline in edgeR provides a complete analysis solution for shRNA-seq screen data, that begins with the raw sequence reads and ends with a ranked lists of candidate shRNAs for downstream biological validation. We first summarize the raw data contained in a fastq file into a matrix of counts (samples in the columns, hairpins in the rows) with options for allowing mismatches and small shifts in hairpin position. Diagnostic plots, normalization and differential representation analysis can then be performed using established methods to prioritize results in a statistically rigorous way, with the choice of either the classic exact testing methodology or a generalized linear modelling that can handle complex experimental designs. A detailed users’ guide that demonstrates how to analyze screen data in edgeR along with a point-and-click implementation of this workflow in Galaxy are also provided. The edgeR package is freely available from http://www.bioconductor.org.
The impact of demographic processes on the productivity of social labor
Authors: Ильичева  , Ilicheva Yu. , Колотова  , Kolotova S. 
Published: July 2014

The article, based on the correlation and regression analysis, we investigate the relationship between demographic processes and productivity of social labor. To this end, consider that processes such as rejuvenation and aging population, fertility, mortality, nuptiality, divorces, migration. As indicators reflecting demographic processes are used: the average age of the population; reproduction rate, indicators of marriage and divorce; ubyvshih number from the Russian Federation and arrivals in the same territory. The result revealed that among all demographic processes and productivity of social labor, there is a close relationship,
which is confirmed by the corresponding regression coefficients. Disclosure extent this relationship possible to determine the factors influencing the growth of national income, including through action on the social and demographic policy of the country.
Choosing relevant organisational culture in the restaurant business
Authors: Зарьков  , Zarkov B. 
Published: July 2014

The problem of a choice of an organizational culture adequate to the situation, in which a specific restaurant business is at the moment, is discussed in the article. After a brief analysis of main organizational cultures, their advantages and disadvantages applied to specificity of the restaurant business it is mentioned that the most common culture in this field is the culture of power. The substance of this culture is quite simple. All power and influence are accumulated along the concentric lines, which surround the leader (in the restaurant business this role most likely belongs to the owner) and diminish with increasing distance from him. The main feature of this type of culture is that the relationship with the leader is much more important than a formal position in a company.
Role culture in restaurant business is more effective when life is easily predictable. Although this culture has low tolerance to any sorts of changes. Typical response of a role culture to the changes is disregard. Another common scenario in case of changes for such culture is to continue functioning just like before, but even more insistently and diligently. Task culture in restaurant business is effective during the early stages of development, for example when creating a new restaurant. Another case of its efficiency is applying it during vast changes, like when a restaurant is changing its concept and style. This culture is not typical and is far from being durable in the restaurant business. In case of failure, it should be rapidly transformed into the culture of power, in case of success — into the role culture.
It is stated that there is no universal solution to the problem of choice of an adequate organizational culture in the restaurant business. In every separate case the choice should be individual, based on the size of the business, its stage of development, market conditions and current organizational technology of the restaurant business.
Sea ice algal biomass and physiology in the Amundsen Sea, Antarctica
Authors: Arrigo Kevin R. , Brown Zachary W. , Mills Matthew M. 
Published: July 2014

AbstractSea ice covers approximately 5% of the ocean surface and is one of the most extensive ecosystems on the planet. The microbial communities that live in sea ice represent an important food source for numerous organisms at a time of year when phytoplankton in the water column are scarce. Here we describe the distributions and physiology of sea ice microalgae in the poorly studied Amundsen Sea sector of the Southern Ocean. Microalgal biomass was relatively high in sea ice in the Amundsen Sea, due primarily to well developed surface communities that would have been replenished with nutrients during seawater flooding of the surface as a result of heavy snow accumulation. Elevated biomass was also occasionally observed in slush, interior, and bottom ice microhabitats throughout the region. Sea ice microalgal photophysiology appeared to be controlled by the availability of both light and nutrients. Surface communities used an active xanthophyll cycle and effective pigment sunscreens to protect themselves from harmful ultraviolet and visible radiation. Acclimation to low light microhabitats in sea ice was facilitated by enhanced pigment content per cell, greater photosynthetic accessory pigments, and increased photosynthetic efficiency. Photoacclimation was especially effective in the bottom ice community, where ready access to nutrients would have allowed ice microalgae to synthesize a more efficient photosynthetic apparatus. Surprisingly, the pigment-detected prymnesiophyte Phaeocystis antarctica was an important component of surface communities (slush and surface ponds) where its acclimation to high light may precondition it to seed phytoplankton blooms after the sea ice melts in spring.
Temporal Activity Patterns and Foraging Behavior by Social Wasps (Hymenoptera, Polistinae) on Fruits of Mangifera indica L. (Anacardiaceae)
Authors: Barbosa Bruno Corrêa , Paschoalini Mariana Frias , Prezoto Fábio 
Published: July 2014

This research was done in Juiz de Fora, Minas Gerais, Brazil on february 2012, with objective was to determine which species of social wasps visiting mango fruits, their behaviors displayed by them while foraging and verify which the species of wasps visitors offer risk of accidents to farmers. The studied area was monitored during February 2012, from 8:00 to 17:00. in a 144 hour effort, and the data collected included the time of activity, diversity, aggressiveness and the general behavior of social wasps around the fruits. There were registered a total of 175 individuals of 12 different species, healthy fruits were damaged during the day, and we registered the abundance and richness peaks throughout the day. This study indicated the needs for special care during the harvest, as aggressive wasps are indeed present and the abundant, resulting in a possible increase of the risk for the workers.
The nostalgic remediation of cinema in Hugo and Paprika
Authors: Annett Sandra 
Published: July 2014

Abstract
This article addresses the ways in which two recent works of digital cinema, Martin Scorsese’s Hugo (2011) and Satoshi Kon’s Paprika (2006) revive classical (photochemical) cinema through what is termed ‘nostalgic remediation’. Rather than seeing nostalgia as ironic, ahistorical pastiche, as in Fredric Jameson’s description of postmodern nostalgia films, this article asks: how can we understand nostalgia as part of our own lived, affective experience of film within today’s new media ecology? To answer this question, it draws on theories of post-celluloid adaptation and remediation to demonstrate the ambivalent relationships between historical and current media platforms seen in digital cinema. These ambivalences, it is argued, reflect the broader anxieties and aspirations that arise in times of technological and social transition, such as the changes brought about by the digitization of media at the turn of the twenty-first century. Hugo and Paprika perfectly illustrate the delicate tension of nostalgic remediation, which shifts between transcending celluloid cinema and longing for its return; between the recovery and loss of cinema’s historical memory; and between the concepts of old and new media themselves.
Rubén Szuchmacher interviewed by Catherine Silverstone
Authors: Silverstone Catherine 
Published: July 2014

Abstract
Rubén Szuchmacher is an award-winning Argentinian stage and film actor, teacher, director of theatre, musical theatre and opera, choreographer, programmer, dramaturge, translator (including collaborations with Lautaro Vilo) and writer, who has made performance and taught since the 1970s in Argentina and internationally. This interview is based on a conversation that took place between Szuchmacher and Catherine Silverstone on 22 May 2012 in the Film and Drama Studio at Queen Mary University of London as part of the Leverhulme Olympic Talks on Theatre and Adaptation. The interview addresses four key aspects of Szuchmacher’s career in relation to adaptation: (1) shifts in his professional roles (e.g. actor, director), (2) adapting to making work under and after Argentina’s military dictatorship (1976–1983), (3) adapting Shakespeare and (4) adapting autobiographical material in performance. It concludes with a consideration of Szuchmacher’s upcoming projects and ‘the future’. The interview reveals aspects of Szuchmacher’s directorial and performance strategies. In particular, it identifies his commitment to narrative clarity and finding solutions to the challenges of making and adapting work for particular spaces, institutional structures and audiences in the context of sometimes difficult political and personal circumstances.
‘The Watergate Theory of Screenwriting’: A keynote presentation at SRN, Wisconsin, 2013
Authors: Gross Larry 
Published: July 2014

Abstract
One way to start to think about making information in a script interesting is to rephrase the question that was posed by the Watergate investigators about then President Richard Nixon’s knowledge of the criminal deeds of his subordinates. The question reiterated obsessively during the Senate Committee investigation, voiced initially by Tennessee Republican Senator Howard Baker, was … ‘What did the president know, and when did he know it?’. In order to get going, scriptwriters must ask: what do the characters know - about narrative context, about themselves, and about each other, and when do they know it? This essay will explore Akira Kurosawa’s 1952 film, Ikiru (co-written with Shinobu Hashimoto and Hideo Oguni), and how the film is masterfully structured in relation to “who knows what and when.”
‘Want to Cook?’: Static and fluid layering in The Sopranos and Breaking Bad
Authors: Rush Jeff 
Published: July 2014

Abstract
Neo-Baroque scholars argue that, because television serials build their story arc on episodic rather than linear structure, they feature the paradigmatic over the syntagmatic axis of story development. This article will extend that argument, claiming that, unlike three-act structure, serial story structure layers character against generic tropes and, as a result, limits character development. It will propose two such strategies for this layering: the static, where the trope remains the same, and the fluid, where the character moves from one trope to the other in the course of the story. In The Sopranos, the example of static layering, even though Tony Soprano pulls against the trope of the gangster don, he always returns to it. By contrast, in Breaking Bad, the example of fluid layering, Walter White is allowed to move through a series of tropes, evolving as a character as he does. However, the evolution is limited by the theme-and-variations style, which ultimately requires that subsequent variations play off of, and recapitulate, the initial theme.
Reviews
Authors: Batty Craig , Devenish Luke 
Published: July 2014

Abstract
The Screenwriter Activist: Writing Social Issue Movies, Marilyn Beker (2013) New York: Routledge, 186 pp., ISBN: 9780415897150, p/bk, £19.99
Death of the Moguls: The End of Classical Hollywood, Wheeler Winston Dixon (2012) New Brunswick, NJ: Rutgers University Press, 247 pp., ISBN: 978 0813553771, p/bk, £23.95
Stiller at first: A footnote
Authors: Olsson Jan 
Published: July 2014

Abstract
This article disentangles the confusion surrounding the production order of Mauritz Stiller’s film activities during his first months at AB Svenska Biografteatern (Svenska bio)/Swedish Biograph in 1912. Drawing on items from the extensive Stockholm press scene, it can be demonstrated that Stiller’s first film production indeed was the one that was first publicly screened, Mor och dotter/‘Mother and Daughter’ (1912) featuring Stiller, Anna Norrie and Lilly Jacobsson. The article also sheds light on Stiller’s role in Stockholm bohemian circles as local film production was ushered in.
The Rise and Demise of Ḥaylä Śəllase I Military Museum (1972–1991)
Authors: Märäsa Nəguś Getaččäw 
Published: July 2014

Abstract
Ḥaylä Śəllase I Military Museum first opened its collections to the public on 5 May 1972, on the 31st anniversary of the Victory Day against the Italians. The selection of this particular date indicates the interest of the state to exploit history for personal glorification. In the displays of the museum, the emperor’s central role was highlighted and his imperial artifacts prominently exhibited. Although the museum claimed to depict the military history of the country, it did not have any display that represented the heritage and history of opposition groups. Another important issue of cultural politics in the museum was the issue of how defeat and victory were celebrated in the museum’s displays. The collapse of the imperial regime in 1974 was followed by a period of confusion and instability in the country. The military socialist government ordered the demolition of all heritage related to the ancien regime. The philosophy of the museum was shaped by this socialist ideology. The museum faced a further predicament when the rebel groups organized under the Ethiopian People’s Revolutionary Democratic Front (EPRDF) overthrew Mängəśtu’s regime and took control of the country in 1991. This paper considers the cultural politics connected to the history of the museum. In particular, it examines the role of heritage in the process of modern nation-building: the appropriation of history and heritage for the purpose of political legitimacy; the celebration of selected heroes and the silencing of others deemed discordant with dominant narratives of the politically powerful; and elite imagination of the history of the Ethiopian empire state as a timeless phenomenon.
Modern possibilities for using stem cells in diabetes mellitus
Authors: Dedov Ivan Ivanovich , Lisukov Igor Andreevich , Laptev Dmitry Nikitich 
Published: July 2014

Diabetes mellitus (DM) is characterised by relative or absolute insulin deficiency. The currently available treatment methods for DM cannot provide normal blood glucose level without hypo- or hyperglycaemia episodes, thus failing to completely prevent the development of diabetic complications. Replacement of ?-cells (transplantation of the pancreas or ?-cells) is accompanied by complications and requires life-long immunosuppressive therapy that is not always followed by restoration of insulin independence; there is also a substantial deficit of donors. Stem cells do not cause such negative effects and can be used in therapy to avoid such problems. Allogeneic stem cell transplantation is complicated by immune rejection of a transplant, whereas the use of embryonic stem cells is associated with ethical concerns, complicated cell line selection, and risk of teratoma formation. The present review focuses on therapeutic pathways of autologous transplantation of tissue stem cells in order to restore the ?-cell pool, for immune reconstitution and modulation of the immune response in DM patients.
Morphological and functional parameters of the heart and vessels in patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy
Authors: Bondar' Irina Arkad'evna , Demin Alexander Aristarkhovich , Shabel'nikova Olesya Yur'evna 
Published: July 2014

Objective. To evaluate morphological and functional parameters of the heart and vessels in patients with type 2 diabetes mellitus (DM2) and diabetic cardiovascular autonomic neuropathy (CAN). Materials and methods. A total of 139 patients with DM2 and hypertension (mean age: 53.1?4.9 years; mean duration of hypertension: 9.7?7.8 years) were included in this study. Based on cardiovascular autonomic function test results (electrocardiography, heart rate variability) patients were divided into 2 groups as follows: Group 1 included 40 patients without CAN and Group 2 included 99 patients with CAN. The control group comprised 30 patients with hypertension and normal carbohydrate metabolism (mean age: 53.1?6.0 years; mean duration of hypertension: 10.9?8.5 years). All patients underwent ultrasonography of the heart and common carotid artery. Results. Group 2 patients showed a significant decrease in maximal transmitral flow velocity during early diastolic filling (0.61?0.12 m/s) and a decrease in maximal transmitral flow velocity during late diastolic filling (0.65?0.11 m/s) compared with Group 1 patients (0.66?0.09 m/s and 0.69?0.09 m/s, respectively, р
A abstenção tabágica: Reflexões sobre a recaída
Authors: Prista Guerra Marina 
Published: July 2014

Nos últimos anos tem-se dado muita ênfase à dependência de drogas duras porque provocam uma diminuição da qualidade de vida dos seus utilizadores, interferem negativamente no funcionamento e ordem social e sobretudo devido à relação com a aquisição de doenças infecciosas como a SIDA e Hepatite C. Esta preocupação crescente, concentrou a maioria das investigações nos toxicodependentes que usam drogas ilícitas e nos fenómenos de segurança social a eles associados, deixando para um segundo plano outras dependências legalmente permissivas como o abuso de fármacos (tranquilizantes e antidepressivos), álcool e o tabaco.O uso de tabaco é no entanto reconhecido como um dos maiores problemas de saúde pública a nível mundial contribuindo segundo as estatísticas para mortes prematuras e deterioração da qualidade de vida dos fumadores, e que vem muitas vezes associado ao consumo de outras drogas. O estudo cuidadoso da influência da nicotina no ser humano a nível biológico, psicológico e social é de suma importância para a intervenção na cessação tabágica e ainda, porque a nicotina exerce a sua influência nomeadamente na absorção de outros produtos naturais ou tóxicos. O problema do tabagismo foi estudado até um passado bem recente, meramente como um hábito que era preciso “descondicionar” e que dependia quase inteiramente da vontade do próprio. Contudo as recentes descobertas da influência positiva da nicotina em determinadas doenças veio abrir caminho para outras investigações que reforçam o poder aditivo desta droga, sobretudo porque se constata, que a maioria dos ex-fumadores tem sucessivas recaídas, tornando a abstenção total a longo prazo muito difícil.Este artigo pretende assim esclarecer aspectos psicológicos, sociais e psicofisiológicos que estão na base do insucesso da manutenção da abstenção tabágica. Enfatizaremos assim os efeitos psicofarmacológicos que proporcionam uma explicação diferente para a futura intervenção no tabagismo e que fornece novas pistas de investigação.