bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon Nanoparticles and Carbonaceous Solids
Authors: Duley W. W. 
Published: March 2015

AbstractThis paper reports on the preparation of hydrogenated amorphous carbon nano-particles whose spectral characteristics include an absorption band at 217.5 nm with the profile and characteristics of the interstellar 217.5 nm feature. Vibrational spectra of these particles also contain the features commonly observed in IR absorption and emission from dust in the diffuse interstellar medium. These materials are produced under “slow“ deposition conditions by minimizing the flux of incident carbon atoms and by reducing surface mobility.
Angular distribution of uplight at 10,000 ft over Berlin
Authors: Kyba Christopher C. M. , Ruhtz Thomas , Lindemann Carsten , Fischer Jürgen , Hölker Franz , Luginbuhl Christian B. 
Published: March 2015

AbstractThe upward emission direction of artificial light from cities is unknown, and is the most important systematic uncertainty in simulations of skyglow. We present a technique for measuring the emission for zenith angles up to 70°.
Dark Sky Collaborators: Arizona (AZ) Observatories, Communities, and Businesses
Authors: del Castillo Elizabeth Alvarez , Corbally Christopher , Falco Emilio E. , Green Richard F. , Hall Jeffrey C. , Williams G. Grant 
Published: March 2015

AbstractWith outdoor lighting ordinances in Arizona first in place around observatories in 1958 and 1972, then throughout the state since 1986, Arizonans have extensive experience working with communities and businesses to preserve our dark skies. Though communities are committed to the astronomy sector in our state, astronomers must collaborate with other stakeholders to implement solutions. Ongoing education and public outreach is necessary to enable ordinance updates as technology changes. Despite significant population increases, sky brightness measurements over the last 20 years show that ordinance updates are worth our efforts as we seek to maintain high quality skies around our observatories. Collaborations are being forged and actions taken to promote astronomy for the longer term in Arizona.
Light pollution in Beijing and effects on Xinglong Station of National Astronomical Observatory
Authors: Lu Ligen , Zhang Baozhou , Liu Jian , Zeng Shanshan 
Published: March 2015

AbstractA night-sky luminance survey was carried on in Beijing to assess the level of light pollution. The luminance of the zenith night sky and skies in four directions at six sites with different distances from the city center was measured by using a photometric luminance meter. The Xinglong Station of National Astronomical Observatory was included to study the impacts of city lights on an astronomical observatory. The survey shows that the night-sky luminance decreases with increasing distance from the city center. Measurement results indicate that outdoor lighting in the Xinglong county town which is close to the observatory has non-negligible influence on the night sky at Xinglong Station.
Night Sky Protection Initiatives in Argentina
Authors: García Beatriz , Álvarez Silvina Pérez , Bibé Victor , Risi Andrés , Gino Lisandro 
Published: March 2015

AbstractLight Pollution is a global problem. Some local actions carried out by a network of professional and amateur astronomers in Argentina are changing the way to attack this problem, taking into account measurements, education, public activities, planetarium shows and legislation proposals.
How cell death shapes cancer
Authors: Labi V , Erlacher M 
Published: March 2015

AbstractApoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malignant clones. However, over the years, a number of studies pointed out that a model in which cell death resistance unambiguously acts as a barrier against malignant disease might be too simple. This is based on paradoxical observations made in tumor patients as well as mouse models indicating that apoptosis can indeed drive tumor formation, at least under certain circumstances. One possible explanation for this phenomenon is that apoptosis can promote proliferation critically needed to compensate for cell loss, for example, upon therapy, and to restore tissue homeostasis. However, this, at the same time, can promote tumor development by allowing expansion of selected clones. Usually, tissue resident stem/progenitor cells are a major source for repopulation, some of them potentially carrying (age-, injury- or therapy-induced) genetic aberrations deleterious for the host. Thereby, apoptosis might drive genomic instability by facilitating the emergence of pathologic clones during phases of proliferation and subsequent replication stress-associated DNA damage. Tumorigenesis initiated by repeated cell attrition and repopulation, as confirmed in different genetic models, has parallels in human cancers, exemplified in therapy-induced secondary malignancies and myelodysplastic syndromes in patients with congenital bone marrow failure syndromes. Here, we aim to review evidence in support of the oncogenic role of stress-induced apoptosis.
T-cell intracellular antigens function as tumor suppressor genes
Authors: Sánchez-Jiménez C , Ludeña M D , Izquierdo J M 
Published: March 2015

AbstractKnockdown of T-cell intracellular antigens TIA1 and TIAR in transformed cells triggers cell proliferation and tumor growth. Using a tetracycline-inducible system, we report here that an increased expression of TIA1 or TIAR in 293 cells results in reduced rates of cell proliferation. Ectopic expression of these proteins abolish endogenous TIA1 and TIAR levels via the regulation of splicing of their pre-mRNAs, and partially represses global translation in a phospho-eukaryotic initiation factor 2 alpha-dependent manner. This is accompanied by cell cycle arrest at G1/S and cell death through caspase-dependent apoptosis and autophagy. Genome-wide profiling illustrates a selective upregulation of p53 signaling pathway-related genes. Nude mice injected with doxycycline-inducible cells expressing TIA1 or TIAR retard, or even inhibit, growth of xenotumors. Remarkably, low expressions of TIA1 and TIAR correlate with poor prognosis in patients with lung squamous cell carcinoma. These findings strongly support the concept that TIA proteins act as tumor suppressor genes.
TRPC1-mediated Ca2+ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy
Authors: Sukumaran P , Sun Y , Vyas M , Singh B B 
Published: March 2015

AbstractAutophagy is a cellular catabolic process needed for the degradation and recycling of protein aggregates and damaged organelles. Although Ca2+ is suggested to have an important role in cell survival, the ion channel(s) involved in autophagy have not been identified. Here we demonstrate that increase in intracellular Ca2+ via transient receptor potential canonical channel-1 (TRPC1) regulates autophagy, thereby preventing cell death in two morphologically distinct cells lines. The addition of DMOG or DFO, a cell permeable hypoxia-mimetic agents, or serum starvation, induces autophagy in both epithelial and neuronal cells. The induction of autophagy increases Ca2+ entry via the TRPC1 channel, which was inhibited by the addition of 2APB and SKF96365. Importantly, TRPC1-mediated Ca2+ entry resulted in increased expression of autophagic markers that prevented cell death. Furthermore, hypoxia-mediated autophagy also increased TRPC1, but not STIM1 or Orai1, expression. Silencing of TRPC1 or inhibition of autophagy by 3-methyladenine, but not TRPC3, attenuated hypoxia-induced increase in intracellular Ca2+ influx, decreased autophagy, and increased cell death. Furthermore, the primary salivary gland cells isolated from mice exposed to hypoxic conditions also showed increased expression of TRPC1 as well as increase in Ca2+ entry along with increased expression of autophagic markers. Altogether, we provide evidence for the involvement of Ca2+ influx via TRPC1 in regulating autophagy to protect against cell death.
Control of coherent information via on-chip photonic–phononic emitter–receivers
Authors: Shin Heedeuk , Cox Jonathan A. , Jarecki Robert , Starbuck Andrew , Wang Zheng , Rakich Peter T. 
Published: March 2015

AbstractRapid progress in integrated photonics has fostered numerous chip-scale sensing, computing and signal processing technologies. However, many crucial filtering and signal delay operations are difficult to perform with all-optical devices. Unlike photons propagating at luminal speeds, GHz-acoustic phonons moving at slower velocities allow information to be stored, filtered and delayed over comparatively smaller length-scales with remarkable fidelity. Hence, controllable and efficient coupling between coherent photons and phonons enables new signal processing technologies that greatly enhance the performance and potential impact of integrated photonics. Here we demonstrate a mechanism for coherent information processing based on travelling-wave photon–phonon transduction, which achieves a phonon emit-and-receive process between distinct nanophotonic waveguides. Using this device, physics—which supports GHz frequencies—we create wavelength-insensitive radiofrequency photonic filters with frequency selectivity, narrow-linewidth and high power-handling in silicon. More generally, this emit-receive concept is the impetus for enabling new signal processing schemes.
Reconciling spatial and temporal soil moisture effects on afternoon rainfall
Authors: Guillod Benoit P. , Orlowsky Boris , Miralles Diego G. , Teuling Adriaan J. , Seneviratne Sonia I. 
Published: March 2015

AbstractSoil moisture impacts on precipitation have been strongly debated. Recent observational evidence of afternoon rain falling preferentially over land parcels that are drier than the surrounding areas (negative spatial effect), contrasts with previous reports of a predominant positive temporal effect. However, whether spatial effects relating to soil moisture heterogeneity translate into similar temporal effects remains unknown. Here we show that afternoon precipitation events tend to occur during wet and heterogeneous soil moisture conditions, while being located over comparatively drier patches. Using remote-sensing data and a common analysis framework, spatial and temporal correlations with opposite signs are shown to coexist within the same region and data set. Positive temporal coupling might enhance precipitation persistence, while negative spatial coupling tends to regionally homogenize land surface conditions. Although the apparent positive temporal coupling does not necessarily imply a causal relationship, these results reconcile the notions of moisture recycling with local, spatially negative feedbacks.
Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records
Authors: Paik Hyojung , Chung Ah-Young , Park Hae-Chul , Park Rae Woong , Suk Kyoungho , Kim Jihyun , Kim Hyosil , Lee KiYoung , Butte Atul J. 
Published: March 2015

AbstractPrediction of new disease indications for approved drugs by computational methods has been based largely on the genomics signatures of drugs and diseases. We propose a method for drug repositioning that uses the clinical signatures extracted from over 13 years of electronic medical records from a tertiary hospital, including >9.4 M laboratory tests from >530,000 patients, in addition to diverse genomics signatures. Cross-validation using over 17,000 known drug–disease associations shows this approach outperforms various predictive models based on genomics signatures and a well-known “guilt-by-association” method. Interestingly, the prediction suggests that terbutaline sulfate, which is widely used for asthma, is a promising candidate for amyotrophic lateral sclerosis for which there are few therapeutic options. In vivo tests using zebrafish models found that terbutaline sulfate prevents defects in axons and neuromuscular junction degeneration in a dose-dependent manner. A therapeutic potential of terbutaline sulfate was also observed when axonal and neuromuscular junction degeneration have already occurred in zebrafish model. Cotreatment with a β2-adrenergic receptor antagonist, butoxamine, suggests that the effect of terbutaline is mediated by activation of β2-adrenergic receptors.
Prognostic Impact of HOTAIR Expression is Restricted to ER-Negative Breast Cancers
Authors: Gökmen-Polar Yesim , Vladislav I. Tudor , Neelamraju Yaseswini , Janga Sarath C. , Badve Sunil 
Published: March 2015

AbstractExpression of HOX transcript antisense intergenic RNA (HOTAIR), a large intergenic noncoding RNA (lincRNA), has been described as a metastases-associated lincRNA in various cancers including breast, liver and colon cancer cancers. We sought to determine if expression of HOTAIR could be used as a surrogate for assessing nodal metastases and evaluated RNA in situ hybridization (RNA-ISH) assay in a tissue microarray constructed from 133 breast cancer patients. The prognostic value of HOTAIR was further validated in large cohorts using The Cancer Genome Atlas (TCGA) breast cancer subjects. RNA-ISH analysis was successful in 94 cases (17% cases scored 0, 32.9% scored 1, 30.8% scored 2 and 19.1% scored 3). The expression of HOTAIR did not correlate with nodal metastasis regardless of the scoring intensity or with other study parameters (age, tumor size and grade, expression status). Further analysis of TCGA dataset showed that HOTAIR expression was lower in ductal carcinomas but higher in ER-negative tumors. Overexpression of HOTAIR was not associated with nodal metastases or prognosis in ER-positive patients. Its function as a poor prognostic indicator in ER-negative patients was restricted to node-positive patients. HOTAIR appears to be a marker for lymphatic metastases rather than hematogenous metastases in ER-negative patients.
Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans
Authors: Kim Hanhae , Jung Kwang-Woo , Maeng Shinae , Chen Ying-Lien , Shin Junha , Shim Jung Eun , Hwang Sohyun , Janbon Guilhem , Kim Taeyup , Heitman Joseph , Bahn Yong-Sun , Lee Insuk 
Published: March 2015

AbstractCryptococcus neoformans is an opportunistic human pathogenic fungus that causes meningoencephalitis. Due to the increasing global risk of cryptococcosis and the emergence of drug-resistant strains, the development of predictive genetics platforms for the rapid identification of novel genes governing pathogenicity and drug resistance of C. neoformans is imperative. The analysis of functional genomics data and genome-scale mutant libraries may facilitate the genetic dissection of such complex phenotypes but with limited efficiency. Here, we present a genome-scale co-functional network for C. neoformans, CryptoNet, which covers ~81% of the coding genome and provides an efficient intermediary between functional genomics data and reverse-genetics resources for the genetic dissection of C. neoformans phenotypes. CryptoNet is the first genome-scale co-functional network for any fungal pathogen. CryptoNet effectively identified novel genes for pathogenicity and drug resistance using guilt-by-association and context-associated hub algorithms. CryptoNet is also the first genome-scale co-functional network for fungi in the basidiomycota phylum, as Saccharomyces cerevisiae belongs to the ascomycota phylum. CryptoNet may therefore provide insights into pathway evolution between two distinct phyla of the fungal kingdom. The CryptoNet web server (www.inetbio.org/cryptonet) is a public resource that provides an interactive environment of network-assisted predictive genetics for C. neoformans.
Intercalation and Retention of Carbon Dioxide in a Smectite Clay promoted by Interlayer Cations
Authors: Michels L. , Fossum J. O. , Rozynek Z. , Hemmen H. , Rustenberg K. , Sobas P. A. , Kalantzopoulos G. N. , Knudsen K. D. , Janek M. , Plivelic T. S. , da Silva G. J. 
Published: March 2015

AbstractA good material for CO2 capture should possess some specific properties: (i) a large effective surface area with good adsorption capacity, (ii) selectivity for CO2, (iii) regeneration capacity with minimum energy input, allowing reutilization of the material for CO2 adsorption and (iv) low cost and high environmental friendliness. Smectite clays are layered nanoporous materials that may be good candidates in this context. Here we report experiments which show that gaseous CO2 intercalates into the interlayer nano-space of smectite clay (synthetic fluorohectorite) at conditions close to ambient. The rate of intercalation, as well as the retention ability of CO2 was found to be strongly dependent on the type of the interlayer cation, which in the present case is Li+, Na+ or Ni2+. Interestingly, we observe that the smectite Li-fluorohectorite is able to retain CO2 up to a temperature of 35°C at ambient pressure and that the captured CO2 can be released by heating above this temperature. Our estimates indicate that smectite clays, even with the standard cations analyzed here, can capture an amount of CO2 comparable to other materials studied in this context.
Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury
Authors: Lorbek Gregor , Perše Martina , Jeruc Jera , Juvan Peter , Gutierrez-Mariscal Francisco M. , Lewinska Monika , Gebhardt Rolf , Keber Rok , Horvat Simon , Björkhem Ingemar , Rozman Damjana 
Published: March 2015

AbstractWe demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14α-demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholesterol. LKO mice developed hepatomegaly with oval cell proliferation, fibrosis and inflammation, but without steatosis. The key trigger was reduced cholesterol esters that provoked cell cycle arrest, senescence-associated secretory phenotype and ultimately the oval cell response, while elevated CYP51 substrates promoted the integrated stress response. In spite of the oval cell-driven fibrosis being histologically similar in both sexes, data indicates a female-biased down-regulation of primary metabolism pathways and a stronger immune response in males. Liver injury was ameliorated by dietary fats predominantly in females, whereas dietary cholesterol rectified fibrosis in both sexes. Our data place defective cholesterol synthesis as a focus of sex-dependent liver pathologies.
Spatio-temporal behaviour of atomic-scale tribo-ceramic films in adaptive surface engineered nano-materials
Authors: Fox-Rabinovich G. , Kovalev A. , Veldhuis S. , Yamamoto K. , Endrino J. L. , Gershman I. S. , Rashkovskiy A. , Aguirre M. H. , Wainstein D. L. 
Published: March 2015

AbstractAtomic-scale, tribo-ceramic films associated with dissipative structures formation are discovered under extreme frictional conditions which trigger self-organization. For the first time, we present an actual image of meta-stable protective tribo-ceramics within thicknesses of a few atomic layers. A mullite and sapphire structure predominates in these phases. They act as thermal barriers with an amazing energy soaking/dissipating capacity. Less protective tribo-films cannot sustain in these severe conditions and rapidly wear out. Therefore, a functional hierarchy is established. The created tribo-films act in synergy, striving to better adapt themselves to external stimuli. Under a highly complex structure and non-equilibrium state, the upcoming generation of adaptive surface engineered nano-multilayer materials behaves like intelligent systems - capable of generating, with unprecedented efficiency, the necessary tribo-films to endure an increasingly severe environment.
Manipulating Topological States by Imprinting Non-Collinear Spin Textures
Authors: Streubel Robert , Han Luyang , Im Mi-Young , Kronast Florian , Rößler Ulrich K. , Radu Florin , Abrudan Radu , Lin Gungun , Schmidt Oliver G. , Fischer Peter , Makarov Denys 
Published: March 2015

AbstractTopological magnetic states, such as chiral skyrmions, are of great scientific interest and show huge potential for novel spintronics applications, provided their topological charges can be fully controlled. So far skyrmionic textures have been observed in noncentrosymmetric crystalline materials with low symmetry and at low temperatures. We propose theoretically and demonstrate experimentally the design of spin textures with topological charge densities that can be tailored at ambient temperatures. Tuning the interlayer coupling in vertically stacked nanopatterned magnetic heterostructures, such as a model system of a Co/Pd multilayer coupled to Permalloy, the in-plane non-collinear spin texture of one layer can be imprinted into the out-of-plane magnetised material. We observe distinct spin textures, e.g. vortices, magnetic swirls with tunable opening angle, donut states and skyrmion core configurations. We show that applying a small magnetic field, a reliable switching between topologically distinct textures can be achieved at remanence.
Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer
Authors: Li Yongsheng , Zhang Yunpeng , Li Shengli , Lu Jianping , Chen Juan , Wang Yuan , Li Yixue , Xu Juan , Li Xia 
Published: March 2015

AbstractDespite growing appreciation of the importance of epigenetics in breast cancer, our understanding of epigenetic alterations of non-coding RNAs (ncRNAs) in breast cancer remains limited. Here, we explored the epigenetic patterns of ncRNAs in breast cancers using published sequencing-based methylome data, primarily focusing on the two most commonly studied ncRNA biotypes, long ncRNAs and miRNAs. We observed widely aberrant methylation in the promoters of ncRNAs and this abnormal methylation was more frequent than that in protein-coding genes. Specifically, intergenic ncRNAs were observed to comprise a majority (51.45% of the lncRNAs and 51.57% of the miRNAs) of the aberrantly methylated ncRNA promoters. Moreover, we summarized five patterns of aberrant ncRNA promoter methylation in the context of genomic CpG islands (CGIs), in which aberrant methylation occurred not only on CGIs, but also in regions flanking CGI and in CGI-lacking promoters. Integration with transcriptional datasets enabled us to determine that the ncRNA promoter methylation events were associated with transcriptional changes. Furthermore, a panel of ncRNAs were identified as biomarkers that discriminated between disease phenotypes. Finally, the potential functions of aberrantly methylated ncRNAs were predicted, suggestiong that ncRNAs and coding genes cooperatively mediate pathway dysregulation during the development and progression of breast cancer.