bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Preparation of Esters and Amides from Carboxylic Acids and N‐Formylation of Amines Promoted by 1,3,5‐Triazo‐2,4,6‐triphosphorine‐2,2,4,4,6,6‐hexachloride (TAPC).
Authors: Bahrami Kiumars , Khodaei Mohammad M. , Targhan Homa , Sheikh Arabi Mehdi 
Published: December 2013

AbstractA simple and new procedure is described to synthesize a variety of carboxylic esters by using TAPC as an effective promoter.
ChemInform Abstract: Investigation of the Scope and Mechanism of Copper Catalyzed Regioselective Methylthiolation of Aryl Halides.
Authors: Joseph P. J. Amal , Priyadarshini S. , Kantam M. Lakshmi , Sreedhar B. 
Published: December 2013

AbstractMechanistic investigations reveal Cu—S—Me to be the effective catalyst in these reactions.
ChemInform Abstract: A Multi‐Component Reaction in the Morita—Baylis—Hillman Route.
Authors: Pal Sudhir Chandra , Bhunia Sankar Chandra 
Published: December 2013

AbstractA new facile stereoselective method for the synthesis of trisubstituted E/Z olefinic thio compounds and 2H‐thiochromenes is accomplished.
ChemInform Abstract: Gold‐Catalyzed Highly Diastereoselective Synthesis of Functionalized 3,4‐Disubstituted Butyrolactams via Phosphatyloxy or Carbonate Double Migrations.
Authors: Yang Weibo , Yu Yang , Zhang Tuo , Hansmann Max M. , Pflaesterer Daniel , Hashmi A. Stephen K. 
Published: December 2013

AbstractA Au/Ag‐catalyzed phosphatyloxy or carbonate double migration of functionalized amides of type (I) offers a highly diastereoselective synthesis of 3,4‐disubstituted butyrolactams.
ChemInform Abstract: Catalytic Enantioselective Addition of Alcohols to Isatin‐Derived N‐Boc Ketimines.
Authors: Li Tian‐Ze , Wang Xi‐Bo , Sha Feng , Wu Xin‐Yan 
Published: December 2013

AbstractThe enantioselective addition of alcohols to isatin‐derived N‐Boc ketimines is investigated for the first time.
ChemInform Abstract: Dehydrative Synthesis of Chiral Oxazolidinones Catalyzed by Alkali Metal Carbonates under Low Pressure of CO2.
Authors: Foo Siong Wan , Takada Yuki , Yamazaki Yusuke , Saito Susumu 
Published: December 2013

AbstractAlkali carbonates such as Cs2CO3 are demonstrated to be efficient catalysts for the synthesis of oxazolidines from chiral aminoalcohols and CO2.
ChemInform Abstract: Straightforward Synthesis of PET Tracer Precursors Used for the Early Diagnosis of Alzheimers Disease Through Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Bort Guillaume , Veitia Maite Sylla‐Iyarreta , Ferroud Clotilde 
Published: December 2013

AbstractA simple one‐step synthesis of a Pittsburgh compound‐B (PiB) precursor through Suzuki—Miyaura cross‐coupling reaction using thermal conditions or microwave activation is described.
ChemInform Abstract: Rhodium Catalyzed Oxidative Coupling of Salicylaldehydes with Diazabicyclic Olefins: A One‐Pot Strategy Involving Aldehyde C—H Cleavage and π‐Allyl Chemistry Towards the Synthesis of Fused Ring Chromanones.
Authors: Jijy E. , Prakash Praveen , Shimi M. , Pihko Petri M. , Joseph Nayana , Radhakrishnan K. V. 
Published: December 2013

AbstractThe title reaction involves the first example of ring opening and ring closing of bicyclic hydrazines (I) via metal catalyzed oxidative coupling reaction.
ChemInform Abstract: Strategy for the Synthesis of Pyridazine Heterocycles and Their Derivatives.
Authors: Abed Hassan Bel , Mammoliti Oscar , Bande Omprakash , Van Lommen Guy , Herdewijn Piet 
Published: December 2013

AbstractA safe and convenient route to functionalized pyridazines of type (V) and (XII) is developed via diaza‐Wittig reaction.
ChemInform Abstract: Assembly of Indolo[1,2‐c]quinazolines Using ZnBr2‐Promoted Domino Hydroamination—Cyclization.
Authors: Xu Min , Xu Ke , Wang Shaozhong , Yao Zhu‐Jun 
Published: December 2013

AbstractA novel methodology to construct the indolo[1,2‐c]quinazoline framework is developed using a 5‐endo‐dig hydroamination and intramolecular cyclization of monoacylated bis(2‐aminophenyl)alkynes.
ChemInform Abstract: A New Method for the Synthesis of Symmetrical Disubstituted Pyrazines.
Authors: Rojas Nora , Grillasca Yvonne , Acosta Alejandrina , Audelo Irene , Garcia de la Mora Gustavo 
Published: December 2013

AbstractSelf‐condensation of α‐amino aldehydes, obtained in situ by reduction of α‐amino methyl esters (I), leads to pyrazines (II) in a three‐step, one‐pot reaction.
ChemInform Abstract: Synthesis and Biological Properties of New N‐Mannich Bases Derived from 3‐Methyl‐3‐phenyl‐ and 3,3‐Dimethyl‐succinimides. Part 5.
Authors: Kaminski Krzysztof , Obniska Jolanta , Chlebek Iwona , Liana Piotr , Pekala Elzbieta 
Published: December 2013

AbstractThe compounds (IVa), (IVb), and (IVe) show best anticonvulsant activity in oral administration experiments in rats.
ChemInform Abstract: Enantioselective Synthesis of Benzofurans and Benzoxazines via an Olefin Cross‐Metathesis—Intramolecular Oxo‐Michael Reaction
Authors: Zhang Jun‐Wei , Cai Quan , Gu Qing , Shi Xiao‐Xin , You Shu‐Li 
Published: December 2013

Abstractusing a catalytic system of Hoveyda—Grubbs 2nd generation catalyst and a chiral BINOL‐derived phosphoric acid
ChemInform Abstract: Synthesis of Novel Diarylamino‐1,3,5‐triazine Derivatives as FAK Inhibitors with anti‐Angiogenic Activity.
Authors: Dao Pascal , Jarray Rafika , Le Coq Johanne , Lietha Daniel , Loukaci Ali , Lepelletier Yves , Hadj‐Slimane Reda , Garbay Christiane , Raynaud Francoise , Chen Huixiong 
Published: December 2013

AbstractCompound (Ia) is found to show significant decrease of autophosphorylation of FAK in HUVEC cells.
ChemInform Abstract: Synthesis of Novel 1‐[(1‐Ethoxymethylene)amino]imidazol‐5(4H)‐ones and 1,2,4‐Triazin‐6(5H)‐ones from Optically Active α‐Aminocarboxylic Acid Hydrazides.
Authors: Kudelko Agnieszka , Zielinski Wojciech , Jasiak Karolina 
Published: December 2013

AbstractIt is demonstrated that hydrazides (I) undergo acid‐catalyzed reactions with triethyl orthoesters (II) to form either imidazolones (III) or 1,2,4‐triazinones (IV) depending on the molar ratio of the orthoesters.
ChemInform Abstract: Oxyazapeptides: Synthesis, Structure Determination, and Conformation Analysis.
Authors: Biswas Suvendu , Abo‐Dya Nader E. , Oliferenko Alexander , Khiabani Amir , Steel Peter J. , Alamry Khalid A. , Katritzky Alan R. 
Published: December 2013

AbstractSubstituting the typical native N—Cα bond with an O—Nα bond, completely new, previously unknown peptidomimetics are created, which are hydrolytically stable and display very interesting conformational behavior.
ChemInform Abstract: An Efficient Way to the Synthesis of 2‐Deoxy‐2‐ [(7‐nitro‐2,1,3‐benzoxadiazol‐4‐yl)amino]‐β‐D‐glucopyranose (2‐NBDG) via 7‐Nitro‐2,1,3‐benzoxadiazol‐4‐yl Chloride (NBD‐Cl).
Authors: He Qi , Wang Zhouyu , Chen Xianggui , Jiang Zhenju , Ai Wensi , Jiang Dehong 
Published: December 2013

AbstractA practical, inexpensive, efficient, and scalable protocol for the synthesis of the title compound is described using Et3N as base.
Pain palliation measurement in cancer clinical trials: The US Food and Drug Administration perspective
Authors: Basch Ethan , Trentacosti Ann Marie , Burke Laurie B. , Kwitkowski Virginia , Kane Robert C. , Autio Karen A. , Papadopoulos Elektra , Stansbury James P. , Kluetz Paul G. , Smith Harry , Justice Robert , Pazdur Richard 
Published: December 2013

BACKGROUNDPain palliation resulting from antitumor therapy provides direct evidence of treatment benefit when combined with evidence of antitumor activity. The US Food and Drug Administration (FDA) previously issued guidance regarding the use of patient‐reported outcome (PRO) measures to support labeling claims. The purpose of this article is to identify common challenges and key design strategies when measuring pain palliation in antitumor therapy clinical trials that are consistent with PRO Guidance principles.METHODSAntitumor clinical protocols submitted to the FDA between 1995 and 2012 that included pain palliation as a primary or secondary endpoint were reviewed. Challenges in critical trial design components were identified. Design strategies consistent with PRO Guidance principles are proposed.RESULTSThe challenges identified were measurement of pain intensity and analgesic use, enrollment eligibility criteria, data collection methods, responder definitions, missing data, and blinding. Strategies included the use of well‐defined, reliable, PRO assessments of pain intensity and analgesics; ensuring that enrollment criteria define patients with clinically significant pain attributable to cancer on an optimal analgesic regimen; defining responders using both pain and analgesic use criteria; incorporating an analysis of tumor response to support evidence of pain response; and minimizing missing data and inadvertent unblinding.CONCLUSIONSImprovement in cancer‐related pain resulting from antitumor therapy is an important treatment benefit that can support drug approval and labeling claims when adequately measured if study results demonstrate statistically and clinically significant findings. Sponsors are encouraged to discuss pain palliation assessment methods with the FDA early in and throughout product development. Cancer 2014;120:761–767. © 2013 American Cancer Society.
Invertebrate specific D1‐like dopamine receptor in control of salivary glands in the black‐legged tick Ixodes scapularis
Authors: Šimo Ladislav , Koči Juraj , Kim Donghun , Park Yoonseong 
Published: December 2013

ABSTRACTThe control of tick salivary secretion, which plays a crucial role in compromising the host immune system, involves complex neural mechanisms. Dopamine is known to be the most potent activator of salivary secretion, as a paracrine/autocrine factor. We describe the invertebrate‐specific D1‐like dopamine receptor (InvD1L), which is highly expressed in tick salivary glands. The InvD1L phylogenic clade was found only in invertebrates, suggesting that this receptor was lost in vertebrates during evolution. InvD1L expressed in Chinese hamster ovary (CHO)‐K1 cells was activated by dopamine with a median effective dose (EC50) of 1.34 μM. Immunohistochemistry using the antibody raised against InvD1L revealed two different types of immunoreactivities: basally located axon terminals that are colocalized with myoinhibitory peptide (MIP) and SIFamide neuropeptides, and longer axon‐like processes that are positive only for the InvD1L antibody and extended to the apical parts of the acini. Both structures were closely associated with the myoepithelial cell, as visualized by beta‐tubulin antibody, lining the acinar lumen in a web‐like fashion. Subcellular localizations of InvD1L in the salivary gland suggest that InvD1L modulates the neuronal activities including MIP/SIFamide varicosities, and leads the contraction of myoepithelial cells and/or of the acinar valve to control the efflux of the luminal content. Combining the previously described D1 receptor with its putative function for activating an influx of fluid through the epithelial cells of acini, we propose that complex control of the tick salivary glands is mediated through two different dopamine receptors, D1 and InvD1L, for different downstream responses of the acinar cells. J. Comp. Neurol. 522:2038–2052, 2014. © 2013 Wiley Periodicals, Inc.
Volatile compounds as indicators of conjugated and unconjugated linoleic acid thermal oxidation
Authors: Cossignani Lina , Giua Laura , Simonetti Maria Stella , Blasi Francesca 
Published: December 2013

In this research, volatiles arising from heating of conjugated (CLA) and unconjugated (LA) linoleic acid, in different chemical forms (free acids, methyl esters, and homogeneous TAGs) have been studied. A solid phase micro‐extraction (SPME) coupled with GC–MS was used to analyze the volatile compounds produced during heating at 180°C for different times (15, 30, 45, and 60 min). Numerous types of volatiles have been identified such as aldehydes, furan fatty acids (FA), alcohols, methyl esters, and methyl‐oxoacids. Results showed that aldehydes were the main volatile compounds both in CLA and LA, even if some differences were found between conjugated and unconjugated systems. In particular, heptanal and trans‐2‐octenal were detected mainly in CLA forms, while trans‐2‐heptenal in LA. Among furan FA, 2‐pentyl‐furan content was higher in LA than in CLA at all treatment times, while 2‐hexyl‐furan was detected in free fatty acid and methyl ester forms of CLA and it was never detected in LA model systems. Among alcohols, 1‐octen‐3‐ol was found only in LA forms. Methylated forms of CLA and LA provided high contents of methyl esters, among which methyl octanoate was the most represented. Therefore heptanal, trans‐2‐octenal, 2‐hexyl‐furan could be considered as characteristic compounds produced during CLA‐rich sample oxidation.Practical applications: Nowadays CLA, known for its interesting beneficial health effects both on animals and humans, is widely used as functional component in numerous foods and nutritional supplements. Besides the more common TAG form, CLA is used also as free fatty acids and methyl esters. To date, studies on CLA oxidation are scarce and the results are sometimes contradictory. For this reason, the comparison of the volatile compounds obtained from different model systems of CLA and LA could be useful to deepen knowledge on secondary oxidation products of some chemical forms of interest for pharmaceutical formulae and CLA‐rich oils. In fact, it is very important to know the secondary products typical of CLA‐ and LA‐based matrices to identify characteristic oxidation compounds of CLA and LA products.
Diversity‐Oriented Approach to Normuscopyridine and Its Analogues through Ring‐Closing Metathesis
Authors: Kotha Sambasivarao , Waghule Gopalkrushna T. , Shirbhate Mukesh E. 
Published: December 2013

AbstractRing‐closing metathesis (RCM) is a useful protocol for assembling macrocycles. To synthesize normuscopyridine, and its analogues we used RCM as a key step in our strategy. Our approach to the synthesis of pyridine macrocycles involves two routes. The first approach starts with alkenylation of 2,6‐bis[(phenylsulfonyl)methyl]pyridine and involves five steps with 10 % overall yield. The second route begins with Grignard addition to pyridine‐2,6‐dicarbo nitrile, followed by RCM and one‐pot removal of the carbonyl group before hydrogenation of the double bond in 28 % overall yield. This approach has only three steps. Neither route involves the use of protecting groups. Various points of diversification are embedded in our strategy and eight different cyclophanes were assembled by adopting a general approach to these macrocyclics.
Monte Carlo simulation of in vivo Raman spectral Measurements of human skin with a multi‐layered tissue optical model
Authors: Wang Shuang , Zhao Jianhua , Lui Harvey , He Qingli , Bai Jintao , Zeng Haishan 
Published: December 2013

AbstractRaman photon generation inside human skin and escaping to skin surface were modeled in an eight‐layered skin optical model. Intrinsic Raman spectra of different skin layers were determined by microscopy measurements of excised skin tissue sections. Monte Carlo simulation was used to study the excitation light distribution and intrinsic Raman signal distortion caused by tissue reabsorption and scattering during in vivo measurements. The simulation results demonstrated how different skin layers contributed to the observed in vivo Raman spectrum. Using the strongest Raman peak at 1445 cm–1 as an example, the simulation suggested that the integrated contributions of the stratum corneum layer is 1.3%, the epidermis layer 28%, the dermis layer 70%, and the subcutaneous fat layer 1.1%. Reasonably good matching between the calculated spectrum and the measured in vivo Raman spectra was achieved, thus demonstrated great utility of our modeling method and approaches for help understanding the clinical measurements. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Biomimetic myocardial patches fabricated with poly(ɛ‐caprolactone) and polyethylene glycol‐based polyurethanes
Authors: Silvestri Antonella , Sartori Susanna , Boffito Monica , Mattu Clara , Di Rienzo Anna M. , Boccafoschi Francesca , Ciardelli Gianluca 
Published: December 2013

AbstractThe production of efficient heart patches for myocardium repair requires the use of biomaterials with high elastomeric properties and controllable biodegradability. To fulfil these design criteria we propose biodegradable poly(ester urethanes) and poly(ether ester urethanes) from poly(ɛ‐caprolactone) (PCL) and poly(ethylene glycol) (PEG) as macrodiols, 1,4‐diisocyanatobutane as diisocyanate, l‐Lysine Ethyl Ester and Alanine‐Alanine‐Lysine (AAK) as chain extenders. This peptide was used to tune biodegradability properties, since the Alanine–Alanine sequence is a target for the elastase enzyme. Enzymatic degradation tests demonstrated the feasibility of tuning biodegradability properties due to the introduction of AAK peptide in polyurethane backbone. Two formulations have been processed into porous scaffolds by Thermally‐Induced Phase Separation (TIPS). Scanning Electron Microscopy micrographs revealed promising microstructures, which were characterized by stretched and unidirectional pores and mimicked the striated muscle tissue. Tensile tests showed that, although scaffolds are characterized by lower mechanical properties than films, these substrates have suitable elastomeric behaviors and elastic moduli for contractile and soft tissue regeneration. Viability tests on cardiomyocytes revealed the best cell response for dense film and porous scaffold obtained from PCL and Lysine Ethyl Ester‐based polyurethane, with an increased viability for the porous substrate, which is ascribable to the morphological features of its microstructure. Future works will be addressed to study the in vivo behavior of these constructs and to confirm their applicability for myocardial tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.
Effects of bone marrow‐derived mesenchymal stem cells and platelet‐rich plasma on bone regeneration for osseointegration of dental implants: Preliminary study in canine three‐wall intrabony defects
Authors: Yun Jeong‐Ho , Han Sang‐Hyun , Choi Seong‐Ho , Lee Myung‐Hyun , Lee Sang‐Jin , Song Sun U. , Oh Namsik 
Published: December 2013

AbstractTissue engineering has been applied to overcome the obstacles encountered with bone regeneration for the placement of dental implants. The purpose of this study was to determine the bone formation ability of human bone marrow‐derived mesenchymal stem cells (BMMSCs) and platelet‐rich plasma (PRP) when applied separately or together to the intrabony defect around dental implants with a porous hydroxyapatite (HA) scaffold. Standardized three‐wall intrabony defects (4 × 4 × 4 mm) were created at the mesial of each dental implant site in four mongrel dogs. Defects were then grafted with the following materials: HA + BMMSCs (HS group), HA + PRP (HP group), HA + BMMSCs + PRP (HSP group), and HA scaffold alone (HA group). The level of bone formation (bone density) and osseointegration (bone‐to‐implant contact [BIC]) in bone defects around the implants were evaluated by histological and histometric analysis at 6 and 12 weeks after the placement of implants. HA, HS, HP, and HSP groups generally showed an increase in bone density and BIC between 6 and 12 weeks, except BIC in the HS group. Although no statistically significant differences were found among HA, HS, HP, and HSP groups (p > 0.05), the highest level of bone density and BIC were observed in the HSP group after the 12‐week healing period. Furthermore, the level of bone maturation was higher in the HSP group than in the other groups as determined histologically. The findings of this preliminary study suggest that BMMSCs and PRP combined with HA scaffold may provide additional therapeutic effects on bone regeneration and improve osseointegration in bone defects around dental implants. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1021–1030, 2014.
Preliminary data on two voice therapy interventions in the treatment of presbyphonia
Authors: Ziegler Aaron , Verdolini Abbott Katherine , Johns Michael , Klein Adam , Hapner Edie R. 
Published: December 2013

Objectives/HypothesisPresbyphonia is common among elderly individuals, yet few studies have evaluated behavioral treatment approaches for presbyphonia. The primary aim of this study was to assess the short‐term efficacy of two types of voice therapy—vocal function exercises (VFE) and phonation resistance training exercise (PhoRTE) therapy—in the treatment of presbyphonia. The secondary aim was to determine if differences in adherence and treatment satisfaction existed between the two therapy approaches.Study DesignProspective, randomized, controlled.MethodsPreliminary data from 16 elderly participants with presbyphonia randomly assigned to VFE, PhoRTE, or a no‐treatment control group (CTL) were analyzed. Before and after a 4‐week intervention period, participants completed the Voice‐Related Quality of Life (V‐RQOL) questionnaire and a perceived phonatory effort (PPE) task. Additionally, participants receiving treatment completed weekly practice logs and a posttreatment satisfaction questionnaire.ResultsPreliminary data revealed VFE and PhoRTE groups demonstrated a significant improvement in V‐RQOL scores. However, only PhoRTE demonstrated a significant reduction in PPE, as suggested by the study's causal model. The CTL group did not demonstrate significant changes. Numerically, VFE registered slightly greater adherence to home practice recommendations than did PhoRTE, but PhoRTE perceived greater treatment satisfaction than VFE.ConclusionsFindings provide new evidence regarding the efficacy of voice therapy exercises in the treatment of age‐related dysphonia and suggest PhoRTE therapy as another treatment method for improved voice‐related quality of life and reduced perceived vocal effort in this population.Level of Evidence2b. Laryngoscope, 124:1869–1876, 2014
Unsuspected pyocyanin effect in yeast under anaerobiosis
Authors: Barakat Rana , Goubet Isabelle , Manon Stephen , Berges Thierry , Rosenfeld Eric 
Published: December 2013

AbstractThe blue–green phenazine, Pyocyanin (PYO), is a well‐known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. It is toxic to both eukaryotic and bacterial cells and several mechanisms, including the induction of oxidative stress, have been postulated. However, the mechanism of PYO toxicity under the physiological conditions of oxygen limitation that are encountered by P. aeruginosa and by target organisms in vivo remains unclear. In this study, wild‐type and mutant strains of the yeast Saccharomyces cerevisiae were used as an effective eukaryotic model to determine the toxicity of PYO (100–500 μmol/L) under key growth conditions. Under respiro‐fermentative conditions (with glucose as substrate), WT strains and certain H2O2‐hypersensitive strains showed a low‐toxic response to PYO. Under respiratory conditions (with glycerol as substrate) all the strains tested were significantly more sensitive to PYO. Four antioxidants were tested but only N‐acetylcysteine was capable of partially counteracting PYO toxicity. PYO did not appear to affect short‐term respiratory O2 uptake, but it did seem to interfere with cyanide‐poisoned mitochondria through a complex III‐dependent mechanism. Therefore, a combination of oxidative stress and respiration disturbance could partly explain aerobic PYO toxicity. Surprisingly, the toxic effects of PYO were more significant under anaerobic conditions. More pronounced effects were observed in several strains including a ‘petite’ strain lacking mitochondrial DNA, strains with increased or decreased levels of ABC transporters, and strains deficient in DNA damage repair. Therefore, even though PYO is toxic for actively respiring cells, O2 may indirectly protect the cells from the higher anaerobic‐linked toxicity of PYO. The increased sensitivity to PYO under anaerobic conditions is not unique to S. cerevisiae and was also observed in another yeast, Candida albicans.