bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consistency analysis of two fingertip capillary blood sampling methods for complete blood count
Authors: Hongxiang Xie , Shiyu Lv , Yanying Zhang , Wanju Xu , Sumei Wang 
Published: July 2024

AbstractThis study was performed to analyze fingertip capillary blood sampling in pediatric patients using microcapillary blood collection tubes and microhematocrit tubes and to compare the blood cell analysis results obtained via these two blood collection methods. Finger capillary blood was collected from 110 outpatients using microcapillary blood collection tubes and microhematocrit tubes and complete blood count analysis was performed with a Sysmex XS-900i hematology analyzer and manual microscopy for blood cell morphology. Paired data was evaluated for agreement and bias using the microhematocrit samples as the reference group and the samples from the microcapillary blood collection tubes as the observation group. The two blood collection methods demonstrated good agreement for measuring red blood cell (RBC) parameters (i.e., RBC, Hb, Hct, MCV, MCH and MCHC), wherein the relative bias was > allowable total error (TEa) in 0.91%, 1.82%, 11.82%, 1.82%, 0.91% and 8.18% of the parameter measures, respectively. According to industry requirements, the proportion of samples meeting the acceptable bias level should be > 80%. Additionally, the estimated biases at each medical decision level were within clinically acceptable levels for RBC, Hb, Hct, and MCV. However, the proportion of WBC and PLT counts with relative bias > TEa was 25.45% and 35.45%, respectively. Furthermore, the relative bias of the WBC count at the medical decision level of 0.5 × 109/L and that of the PLT counts at the medical decision levels of 10 × 109/L and 50 × 109/L were clinically significant. Bland–Altman analysis further showed a mean bias of 0.66 × 109/L (95% LoA, − 0.79 to 2.11) for the WBC count and 39 × 109/L (95% LoA, − 46 to 124) for the PLT count from the blood samples collected in the microcapillary blood collection tubes compared with the counts of those collected in the microhematocrit tubes. Neutrophil, monocyte, lymphocyte, eosinophil, and PLT counts increased significantly in the microcapillary blood collection tubes compared with those in the microhematocrit tubes, along with an elevated number of instrument false alarms (P < 0.05). The two capillary blood collection devices exhibit performance differences. Therefore, clinicians should pay attention to the variation in results caused by different blood collection methods.
Non-equilibrium molecular dynamics study of heat transfer parameters in two-dimensional Yukawa systems under uniform magnetic field
Authors: Djienbekov N. E. , Bastykova N. Kh. , Ramazanov T. S. , Kodanova S. K. 
Published: July 2024

AbstractThe present study explores the effect of a magnetic field on the thermal conductivity of two-dimensional (2D) Yukawa systems in a wide range of system parameters using the non-equilibrium molecular dynamic method (NEMD). We consider an external magnetic field with $$\Omega =\omega _c/\omega _p\le 1$$

Ω
=

ω
c

/

ω
p

≤
1

(with $$\Omega$$
Ω
being the ratio of the cyclotron frequency to plasma frequency) and the coupling parameter values in the range $$1\le \Gamma \le 100$$

1
≤
Γ
≤
100

(with $$\Gamma$$
Γ
being the ratio of the Coulomb interaction energy at mean inter-particle distance to the thermal energy of particles). The results show that an external uniform magnetic field results in the reduction of the thermal conductivity at the considered values of the coupling parameter $$\Gamma$$
Γ
. Additionally, we found that the effect of the magnetic field on thermal conduction is weaker at larger values of the system coupling parameter. To ensure that calculated results for the thermal conductivity are accurate and reliable, we performed a detailed investigation of the convergence of the results with respect to simulation parameters in NEMD with a strong external magnetic field. We believe that the presented results will serve as useful benchmark data for the theoretical models of (2D) Yukawa systems.
Malnutrition contribution to the functional status and health related quality of life after COVID-19, a correlational follow-up study
Authors: Mejía Alonso Laura Alejandra , Espinosa-Poblano Eliseo , de Regil López Sarahi , Lemus Eslava Verónica , Serrano Sánchez Jesús Guadalupe , Paredes-Manjarrez Carlos , Balderas-Chairéz Andrés Tlacaelel , Anda-Garay Juan Carlos , Miguel-Puga José Adán , Jáuregui-Renaud Kathrine 
Published: July 2024

AbstractTo assess malnutrition contribution to the functional status and health related quality of life after hospitalization due to COVID-19 pneumonia, 66 selected adults referred for physical rehabilitation accepted to participate in the study; none of them required oxygen supply or had history of lung/musculoskeletal/neurological/immune/rheumatic disease or trauma, or contraindication for respiratory-function tests. At three evaluations, with 3 months in-between, assessments included: self-report of functional status, the St. George’s Respiratory Questionnaire, spirometry, the 6-min-walk-test, the MRC-scale, the 30-s sit-to-stand-test, the timed-up-and-go-test, nutritional status, and ultrasound imaging (vastus medialis and diaphragm). At referral, patients had nutritional deficits with protein deficiency, which gradually improved; while muscle thickness (of both vastus medialis and diaphragm) increased, along with muscle strength and mobility (ANOVA, p < 0.05). Contrarywise, the distance covered during the 6-min-walk-test decreased (ANOVA, p < 0.05), with a negative influence from excess body mass. During rehabilitation, health-related quality of life and functional status improved, with negative influence from a history of tobacco use and referral delay, respectively. After hospitalization due to COVID-19, early diagnosis of both protein deficiency and decrease of skeletal muscle thickness could be relevant for rehabilitation, while pondering the negative impact of excess body mass on submaximal exercise performance.
An increase of serum CA-125 to two times of nadir level strongly predicts the image-identified relapse of serous ovarian cancer
Authors: Du Kaiwen , Li Qian , Huang Jin , Chan David Wai , Li Jinjin , Chang Xiaoxia , Wang Hanjie , Tang Junying , Yang Qiyu 
Published: July 2024

AbstractUsing 70 U/ml or 35 U/ml as CA125 routine abnormal threshold may result in omissions in the relapse detection of Ovarian cancer (OvCa). This study aimed to clarify the association between a biochemical relapse (only the elevation of CA125) and an image-identified relapse to predict the relapsed lesions better. 162 patients who achieved complete clinical response were enrolled from women diagnosed with stage I-IV serous ovarian, tubal, and peritoneal cancers from January 2013 to June 2019 at our center. The CA125 level of 2 × nadir was defined as the indicator of image-identified relapse (P < 0.001). Compared to CA125 level exceeding 35 U/ml, the 2 × nadir of CA125 improve the sensitivity of image-identified relapse (84.9% vs 67.4%, P < 0.001); the 2 × nadir value can act as an earlier warning relapse signal with a longer median time to image-identified relapse (2.7 vs. 0 months, P < 0.001). Of the relapsed population, there was no difference of CA125 changing trend between the neoadjuvant chemotherapy (NACT) and primary debulking surgery (PDS) group after initial treatment. Compared with 35 U/ml, CA125 reaching 2 × nadir during the follow-up process might be a more sensitive and early relapse signal in patients with serous OvCa. This criterion may help guide patients to be recommended for imaging examination to detect potential relapse in time.
CohortFinder: an open-source tool for data-driven partitioning of digital pathology and imaging cohorts to yield robust machine-learning models
Authors: Fan Fan , Martinez Georgia , DeSilvio Thomas , Shin John , Chen Yijiang , Jacobs Jackson , Wang Bangchen , Ozeki Takaya , Lafarge Maxime W. , Koelzer Viktor H. , Barisoni Laura , Madabhushi Anant , Viswanath Satish E. , Janowczyk Andrew 
Published: July 2024

AbstractBatch effects (BEs) refer to systematic technical differences in data collection unrelated to biological variations whose noise is shown to negatively impact machine learning (ML) model generalizability. Here we release CohortFinder (http://cohortfinder.com), an open-source tool aimed at mitigating BEs via data-driven cohort partitioning. We demonstrate CohortFinder improves ML model performance in downstream digital pathology and medical image processing tasks. CohortFinder is freely available for download at cohortfinder.com.
Grüne Nephrologie – was bedeutet dies für die Dialyseverfahren?
Authors: Boedecker-Lips Simone Cosima , Weinmann-Menke Julia 
Published: July 2024

ZusammenfassungIn Zeiten, in denen der Klimawandel durch die Erderwärmung immer deutlicher im Alltag der globalen Bevölkerung zu spüren ist, gilt: In allen Bereichen unseres menschlichen Handels (u.a. auch im Bereich der Medizin) ist ein Umdenken, hin zu einer umweltfreundlichen und klimaneutralen Lebensweise, unabdingbar. Im Bereich der Nephrologie ist daher zwingend eine Neuausrichtung der ressourcenintensiven Nierenersatztherapie nötig – Stichwort „Grüne Nephrologie“. Dabei muss zunächst das Bewusstsein für die verursachten CO2-Emissionen im Fachbereich Nephrologie geschärft werden, um dann in der Folge CO2-Einsparungen effizient umsetzen zu können. Dies wird zunächst unter Gebrauch der aktuell herkömmlichen Dialyseverfahren geschehen. Zudem werden zukünftig durch technische Weiterentwicklungen, wie portable und tragbare Hämo- und Peritonealdialyse-Geräte, deutliche Einsparungen an Energie- und Wasserverbrauch möglich sein. Des Weiteren führen innovative Forschungsansätze, wie Xenotransplantation, Stammzellforschung und der „künstliche“ Organersatz, zu neuen Alternativen zur Organtransplantation. Für die Nierenersatztherapie der Zukunft stehen somit unterschiedliche vielversprechende Ansätze zur Verfügung. Ziel der Nephrologie muss es nun sein, die Weiterentwicklung so voranzutreiben und zum Einsatz zu bringen, dass zeitnah eine umweltfreundliche Patient*innen-Versorgung in der Nephrologie möglich ist, um unseren Beitrag zum Klimaschutz zu leisten – bei gleichzeitiger Sicherstellung der Behandlung und ihrer Qualität.
Discharge mode and particle transport in radio frequency capacitively coupled Ar/O2 plasma discharges
Authors: Gao 高 Zhuo-Yao 卓瑶 , Dong 董 Wan 婉 , Tian 田 Chong-Biao 崇彪 , Jiang 蒋 Xing-Zhao 星照 , Dai 戴 Zhong-Ling 忠玲 , Song 宋 Yuan-Hong 远红 
Published: July 2024

Abstract
Simulations are conducted on capacitively coupled Ar/O2 mixed gas discharges employing a one-dimensional fluid coupled with an electron Monte Carlo (MC) model. The research explores the impact of different O2 ratio and pressures on the discharge characteristics of Ar/O2 plasma. At a fixed Ar/O2 gas ratio, with the increasing pressure, higher ion densities, as well as a slight increase in electron density in the bulk region can be observed. The discharge remains dominated by the drift–ambipolar (DA) mode, and the flux of O(3P) at the electrode increases with the increasing pressure due to higher background gas density, while the fluxes of O(1D) and Ar* decrease due to the pronounced loss rate. With the increasing proportion of O2, a change in the dominant discharge mode from α mode to DA mode can be detected, and the O2-associated charged particle densities are significantly increased. However, Ar+ density shows a trend of increasing and then decreasing, while for neutral fluxes at the electrode, Ar* flux decreases, and O(3P) flux increases with the reduced Ar gas proportion, while trends in O(1D) flux show slight differences. The evolution of the densities of the charged particle and the neutral fluxes under different discharge parameters are discussed in detail using the ionization characteristics as well as the transport properties. Hopefully, more comprehensive understanding of Ar/O2 discharge characteristics in this work will provide a valuable reference for the industry.
Far-red light effects on plant photosynthesis: from short-term enhancements to long-term effects of artificial solar light
Authors: Lazzarin Martina , Dupont Killian , van Ieperen Wim , Marcelis Leo F M , Driever Steven M 
Published: July 2024

Abstract

Background and Aims
Long-term exposure over several days to far-red light (FR) increases leaf expansion, whereas short-term exposure (minutes) might enhance the photosystem II operating efficiency (ϕPSII). The interaction between these responses at different time scales and their impact on photosynthesis at the whole-plant level are not well understood. We aimed to assess the effects of FR in an irradiance mimicking the spectrum of sunlight (referred to as artificial solar irradiance), in both the long and short term, on whole-plant CO2 assimilation rates and in leaves at different positions in the plant.

Methods
Tomato (Solanum lycopersicum) plants were grown under artificial solar irradiance conditions with either a severely reduced or normal fraction of FR [SUN(FR−) vs. SUN]. To elucidate the interplay between the growth light treatment and the short-term reduction of FR, we investigated this interaction at both the whole-plant and leaf levels. At the whole-plant level, CO2 assimilation rates were assessed under artificial solar irradiance with a normal fraction and a reduced fraction of FR. At the leaf level, the effects of removal and presence of FR (0FR and 60FR) during transition from high to low light on CO2 assimilation rates and chlorophyll fluorescence were evaluated in upper and lower leaves.

Key Results
SUN(FR−) plants had lower leaf area, shorter stems and darker leaves than SUN plants. Although reducing FR during growth did not affect whole-plant photosynthesis under high light intensity, it had a negative impact at low light intensity. Short-term FR removal reduced both plant and leaf CO2 assimilation rates, but only at low light intensity and irrespective of the light treatment during growth and the leaf position. Interestingly, the kinetics of ϕPSII from high to low light were accelerated by 60FR, with a larger effect in lower leaves of SUN than in SUN(FR−) plants.

Conclusions
Growing plants with a reduced amount of FR light lowers whole-plant CO2 assimilation rates at low light intensity through reduced leaf area, despite maintaining similar leaf-level CO2 assimilation to leaves grown with a normal amount of FR. The short-term removal of FR brings about significant but marginal reductions in photosynthetic efficiency at the leaf level, regardless of the long-term growth light treatment.
Mental Health Rather than Mental Disorders as a Predictor of Immediate Postoperative Recovery After Elective Lumbar Fusion
Authors: Solomito Matthew J. , Kostyun Regina O. , Dzurec Laura , Makanji Heeren 
Published: July 2024

Study Design.
Retrospective comparative cohort

Objective.
Investigate how a patient’s mental health, as measured using the PROMIS-10 Global Mental Health T score (MHT), influences their in-hospital recovery after elective 1- to 2-level lumbar fusion.

Summary of Background Data.
The intersection of mental and physical health among candidates for lumbar fusion has increased. Although there is strong evidence to suggest mental disorders can influence a patient’s postoperative recovery, there is a paucity of information detailing the association between unrecognized low mental health and surgical outcomes. The MHT may provide a more nuanced insight into a patient’s preoperative mental health status.

Methods.
A total of 637 patients who underwent 1- or 2-level elective lumbar fusion between April 2020 and June 2023 were analyzed for this study. Patients were stratified by their MHT (above average [AA] >50, control 40 to 50, below average [BA] <40) regardless of mental illness diagnosis. Outcome measures including pain scores both during activity and at rest, opioid consumption during the in-hospital stay, and ambulation distance were compared among groups using both univariate and multivariate models to control for confounders.

Results.
The majority of patients reported average (41.4%) to above-average (35.3%) mental health. After controlling for confounders, findings suggested that patients in the BA group reported higher pain, consumed more opioids, and had shorter ambulation distances than patients in the AA group (P=0.004, P=0.008, and P=0.020, respectively). Patients in the AA group were 84% less likely to be discharged to a facility than the BA group (P=0.001).

Conclusion.
The MHT was an independent predictor of immediate postsurgical recovery, whereas a mental disorder diagnosis was not. A preoperative MHT <40 may represent an additional risk factor that has not previously been identified in patients undergoing elective lumbar fusion.
Assessing the clinical outcomes of Dazhu Hongjingtian injection for the management of stable and unstable angina: Protocol for a prospective observational study
Authors: Song Tian , Che Qianzi , Liang Ning , Guo Jing , Liu Xiaoyu , Yang Lu , Jiang Yin , Shi Nannan , Wang Yanping 
Published: July 2024

Background:
The global rise in angina pectoris, a symptom of coronary artery disease, is primarily attributed to an aging population and increasing prevalence of comorbidities. This study aims to assess the efficacy and safety of Dazhu Hongjingtian injection (DZHJTI) as an adjunct treatment for both stable and unstable angina, thereby addressing a significant gap in current cardiac care research.

Methods:
This comprehensive study involves 2 parallel prospective cohorts across 28 medical centers in China, enrolling 1500 patients with stable angina and 2000 with unstable angina. Participants are randomized into 2 groups: one receiving the DZHJTI alongside standard therapy and the other receiving standard therapy alone. The study employs advanced statistical methods like Subgroup Analysis and Marginal Mean Weighting Through Stratification to analyze data accurately.

Discussion:
The primary outcome of this study is the reduction in the frequency of angina attacks posttreatment. Secondary outcomes include the evaluation of patient well-being through clinical measures such as nitrate dosage requirements, vital sign stability, electrocardiogram changes, and laboratory data. Patient-reported outcomes from targeted questionnaires will also be assessed to understand the impact on quality of life. The study’s results are expected to contribute significantly to the understanding of DZHJTI’s role in treating angina pectoris, potentially influencing future treatment guidelines.
Identifying Genetic Mutations in Vascular Anomalies Using a Sequencing Panel for Childhood Cancers: A Pilot Study
Authors: Lee Elis Yuexian , Ang Yi Shan , Kuick Chik Hong , Mok Yingting , Chang Kenneth Tou En , Toh Luke Han Wei , Chan Mei Yoke , Koh Mark Jean Aan 
Published: July 2024

Introduction:
Genetic mutations have been identified in the pathogenesis of vascular anomalies. Due to overlaps in genetic variants causing vascular anomalies and cancer, we used a next-generation sequencing panel for genomic profiling of childhood cancers to detect somatic mutations in children with vascular anomalies. We aim to review the utility of an oncology panel for the molecular diagnosis of vascular anomalies.

Methods:
Nine patients with histologically confirmed vascular anomalies were included. DNA was extracted from formalin-fixed paraffin-embedded tissue specimens obtained from affected tissue following diagnostic punch biopsies of the skin and core biopsies of the vascular malformation or tumor during sclerotherapy or surgical excision. Molecular analysis of the tissue samples was performed using AmpliSeq for Childhood Cancer DNA Assay Panel.

Results:
Two patients had antenatally detected vascular anomalies. The median age at diagnosis for the remaining patients was 7.0 years (IQR, 0.6–10.0 years). Seven were diagnosed with vascular malformations, while 2 had vascular tumors. Pathological somatic mutations were identified in 4 patients, leading to a diagnostic yield of 44.4%. Two different PIK3CA mutations were identified in 3 cases: 1 in a case of macrocystic lymphatic malformation, the other in a case of Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevus, Spinal/Skeletal anomalies syndrome and Klippel–Trenaunay syndrome. BRAF mutation was identified in a patient with a veno-lymphatic malformation.

Conclusion:
An oncology next-generation sequencing panel can be used for genetic profiling of vascular anomalies. However, a more customized and sensitive panel may be of better diagnostic yield, as detection of somatic mutations in vascular anomalies is challenging due to tissue mosaicism, low-abundant genetic variants, and specimen limitations.
Role of vitamin D supplement adjunct to topical benzoyl peroxide in acne: a randomized double-blinded controlled study
Authors: Ruikchuchit Tin , Juntongjin Premjit 
Published: July 2024

Background:Acne is an inflammatory condition of the pilosebaceous unit. Previous studies have established a link between acne and vitamin D deficiency and the potential effectiveness of vitamin D supplementation in treatment. However, the efficacy of vitamin D as an adjuvant treatment for acne remains unknown.Objective:To evaluate the efficacy of weekly vitamin D2 oral administration as an adjunctive treatment to standard topical care for acne.Methods:This study was a randomized, double-blind, placebo-controlled trial including subjects with mild-to-moderate acne. Topical 2.5% benzoyl peroxide was applied twice daily for 12 weeks to all subjects. Subjects were randomly allocated to receive either oral vitamin D2 40,000 IU weekly or placebo weekly during the treatment period. No additional treatment was administered during the 4-week follow-up period.Results:A total of 44 subjects were included in this study. All of them had inadequate 25(OH)D levels. Both regimens showed significant improvement in acne during the treatment period. Weekly vitamin D2 supplementation significantly prevented the relapse of inflammatory acne lesions (P= .048) at the follow-up visit. No adverse effects or biochemical changes were observed.Limitations:There were no subjects of severe acne vulgaris.Conclusion:Adjunctive weekly vitamin D2 supplementation to standard topical benzoyl peroxide could reduce relapses of inflammatory lesions in mild-to-moderate acne.
Computed tomography angiography and coronary artery disease–reporting and data system and a 5-year prognostic major adverse cardiovascular and cerebral event outcome study in a symptomatic Southeast Asian population
Authors: Witoonchart Kan , Wannit Witoonchart , Kumpol Chintanavilas 
Published: July 2024

Background
This study investigated the relationship between coronary artery disease–reporting and data system (CAD-RADS) for coronary computed tomography angiogram (CCTA) and major adverse cardiovascular and cerebral event (MACE) in a symptomatic Southeast Asian, Thai population over a 5-year period.

Methods
A retrospective cohort study of Thai patients without known CAD who underwent CCTA for CAD symptoms. CCTA images and 5-year health data were reviewed for CAD-RADS and MACE. MACE consists of all-cause mortality, cardiovascular death, acute coronary syndrome, heart failure hospitalization, and stroke.

Results
In total 336 patients were evaluated. The median follow-up period was 6.4 years. The overall MACE incidence was 63 cases (18.8%). The MACE event rate was progressively increased with higher CAD-RADS categories; CAD-RADS 3 [hazard ratio (HR), 3.62; P = 0.015], CAD-RADS 4a (HR, 3.50; P = 0.024), CAD-RADS 4b & 5 (HR, 7.56; P = 0.001). The risk of MACE increased significantly in the moderate to severe CAD burden group (HR, 5.58; P = 0.01). Kaplan–Meier curve showed a significant rise in MACE with higher CAD-RADS categories (P = 0.01).

Conclusion
CAD-RADS classification has a significant prognostic value in Southeast Asian, Thai population with cardiac symptoms.