bluuebunny/crossref_metadata_2025_split huggingface dataset:
OP‐16 DIETARY INTERVENTION USING THE LOW FODMAP DIET VERSUS THE “MILK, EGG, WHEAT AND SOYA FREE” DIET FOR TREATMENT OF FUNCTIONAL GUT DISORDERS A SINGLE CENTRE EXPERIENCE
Authors: Keetarut K. , Kiparissi F. , McCartney S. , Murray C. 
Published: September 2015

Introduction:The adolescent clinic is a tertiary referral clinic including patients with a wide variety of complex gastroenterology conditions predominantly tertiary referrals fromGreat Ormond Street Hospital transition clinic. Purpose: To assess the benefit of the low FODMAP diet versus the “Milk, egg, wheat and soya” (MEWS) free diet for symptom control in patients with functional gut disorders and/or food allergy from June 2013 to June 2015.Methods:A total of 436 patients were seen during this time period for dietetic advice and the age range varied from 13–21 years old with 43terms of diagnosis used. These included the broad categories of inflammatory bowel disease, food allergy, functional gut conditions, congenital gut disorders, autoimmune disorders and oncology conditions. For functional gut disorders/food allergy there were 14 terms used which varied from “Functional gut disorder” to “Irritable bowel syndrome” and also included patients with delayed gastric emptying. For patients with food allergy the terms “multiple food allergy” or EosinophilicOesophagitis or Colitis were used. A total of 40 patients with functional gut disorders were referred for the MEWS or low FODMAP diet. The efficacy of the diet was measured using a symptom scale pre and post dietary intervention assessing if patients symptoms changed from nil/mild/moderate tosignificant. The results indicate whether the presenting predominant symptom e.g., bloating, constipation or abdominal pain improved following the dietary intervention.Results:A total of 29 patients were seen for the “MEWS” free diet.These were 17 functional, 3 food allergy, 6 IBS, 2 EosinophilicOesophagitis, 1 oncology patient. The age ranged from 14 to 21 and average ageat treatment was 16.6 years old with 11 males and 18 females. 13 patients were referred for the low FODMAP diet. The patients referred for the low FODMAP diet were 7 with a functional gut disorder, 5Irritable Bowel Syndrome and1 EosinophilicColitis. The age range was 14 to 19 years old with average age at treatment 16.3 years old. There were 6 males and 7 females. The success rate of the MEWS diet measured by reported significant improvement in predominant presenting symptom was 14/29 (48.2%),moderate 4/29 (13.7%) mild 2/29(6.9%) and 9/29 (31%) nil improvement. For the low fodmap diet 6/13 (46.1%) of patientsreported a significant improvement in symptoms,0/13 (0%) moderate,mild 2/13 (15.4%)and 5/13 (38.5%) had nil improvement.Conclusions:This review suggests that although there were larger referral rates for the MEWS diet both the MEWS and low FODMAP diet appear to beequally effective dietary approaches for treating patients with functional gut disorders and/or food allergy.
OP‐17 INFANT DYSCHEZIA IN SRI LANKAN CHILDREN
Authors: Hovenkamp Anne , Walter Hannah A.W. , Devanarayana Niranga M. , Rajindrajith Shaman , Benninga Marc A. 
Published: September 2015

Objectives:Little is known regarding functional gastrointestinal diseases in infants, especially in developing countries. Our aim was to assess the prevalence of infant dyschezia in relation to bowel habits and sociodemographic factors in a representative community sample in Sri Lanka.Methods:A multicentre cross‐sectional study was conducted among mothers of 0 ‐7‐month‐old infants, attending 14 growth monitoring and immunization clinics in Gampaha District, Sri Lanka. A self‐administered questionnaire was used to determine gastrointestinal symptoms, the infant's bowel habits and sociodemographic characteristics for a total of 1004 infants. The questionnaire was translated to the native language (Sinhala) and pretested. Infant colic and infant dyschezia were diagnosed according to the Rome III criteria.Results:The prevalence of infant dyschezia in Sri Lanka was 4.3%. An infant was more likely to suffer from infant dyschezia if he or she was formula‐fed (9.6% vs. 7.8% in breast fed and 4.2% in those on additional foods, P = 0.025) or had a highly educated father (mean years of education 13.5 [SD 4.0] vs. 12.3 [SD 2.6] in unaffected children, P = 0.005). No significant association was found between infant dyschezia and age, sex, gestational age, birth order, birth weight, current weight, and presence of domestic violence (P > 0.05).Conclusions:Infant dyschezia is a significant health problem in Sri Lanka affecting approximately 4.3% of healthy infants. Infants with infant dyschezia are more likely to be formula‐fed and have a highly educated father.
OP‐21 QUALITY OF LIFE BEFORE AND AFTER BIOFEEDBACK TREATMENT IN MYELOMENINGOCELE PATIENT
Authors: Zubiri C. E , Bigliardi R , Miculan S , Nanfito G 
Published: September 2015

Introduction:Myelomeningocele is the most common birth defect that causes physical disability, causing fecal incontinence and thus preventing the social integration of these children and adolescents since they reach adulthood being incontinent.Objective:To improve the quality of life and manometric values after biofeedback therapy.Method:longitudinal, prospective, analytical and experimental study. The study includes children 5 to 15 years with myelomeningocele and fecal incontinence and their parents. After obtaining informed consent and assent, the PedsQMtm generic questionnaire was applied and anorectal manometry and initial biofeedback sessions were then conducted. After treatment completion, the questionnaire was applied again aforementioned. The analysis was done following the Student test and Fisher and Chi square.Results:A total of 17 patients aged between 5 and 15 years and their parents were included in the study. Initially all the patients presented fecal incontinence using diapers and did not use toilet.Only 3 children requiring the use of wheelchairs to roam and 2 orthopedic equipment; the remaining 12 (70.6%) walked without any equipment.After treatment, all patients improved their fecal incontinence and nine of them stop using diaper (P = 0,0005674). All started the use of the toilet (P = 0,0000001).Comparing manometric results to begining and the end of treatment with biofeedback we improved voluntary contraction and sensitivity With a P value of 0.00002 and 0.004 respectively. With these results we can prove that there is relationship between biofeedback treatment and improvement in the sensivity and voluntary contraction.As to test quality of life of children and parents at the beginning and end of treatment, statistically significant differences were observed. It follows from this analysis that there is an improvement in the quality of life for both children and parents after the treatment with biofeedback. But this improvement was most noticeable in the parents than children.Conclusions:Clinical improvement and manometry data provides highly significant values. The improvement in quality of life is more notable in the parents. Perhaps these children have developed strategies and stronger psychosocial skills than their parents, because they were born with the disorder and assume daily as such. Unlike parents who encounter this unexpected situation in their lives.
PP‐8 ESOPHAGEAL HIGH RESOLUTION MANOMETRY IN NEUROLOGICALLLY IMPAIRED CHILDREN AND GASTRO‐OESOPHAGEAL REFLUX DISEASE
Authors: Turco R. , Ummarino D. , Miele E. , Terrone G. , Del Giudice E. , Staiano A. 
Published: September 2015

Objectives:Mechanism underlying the occurrence of Gastroesophageal reflux disease (GERD) in neurologically impaired children (NIC) is poorly understood. We sought to characterize, by Esophageal High Resolution Manometry (EHRM), alterations of esophageal motility associated with GERD in NIC and to compare with a group with a suspicion of GERD and normal psychomotor development (NDP).Methods:EHRM and multichannel intraluminal impedance/pH‐metry (MII/pH) were conducted in 7 NIC and 9 patients with suspicion of GERD and NPD. Esophagogastric junction relaxation (EGJr), the presence/pressure troughs of the oesophageal segments, the distal contractile integral adjusted for esophageal length (DCIa) and the pressurization frontal velocity (PFV) were analyzed by EHRM.Results:Three out of 7 NIC (42.8%) and 4 out of 9 patients with NPD (44.4%) resulted positive to MII/pH (p = 1). No statistical differences were observed for EGJr and PFV between NIC and NPD patients. DCIa was significantly lower in NIC subjects respect to NPD patients (p < 0.01). Comparing NIC with GERD and patients with GERD and NPD we found that third segment was absent in 2/3 (66,6 %) of NIC respect to NPD patients (p < 0.05) and that the third pressure trough was significantly lower in NIC respect to NPD patients (p < 0.05). There were no statistical differences with respect to the first and second pressure trough between NIC and NDP patients.Conclusions:NIC have esophageal motor dysfunction that can be detected by EHRM. Some esophageal manometric alterations could be predictive of GERD in NIC and could explain a different pathogenesis of GERD in NIC and in patients with NPD.
PP‐9 NORMAL VALUES OF 3D HIGH‐RESOLUTION ANORECTAL MANOMETRY IN CHIDREN
Authors: Banasiuk Marcin , Banaszkiewicz Aleksandra , Albrecht Piotr 
Published: September 2015

Background and Aims:3D high‐resolution anorectal manometry (3D HRAM) provides a 3D topographic image of pressure along the anal canal. The aim of the study was to determine normal values of 3D HRAM in children.Methods:Children without any symptoms arising from the lower gastrointestinal tract were prospectively enrolled in the study. Manometry procedures were performed using a rigid probe (Covidien/Medtronic, Ireland) without premedication. Pressure within the anal canal and 3D images of sphincters were measured. If possible, defecation dynamics and thresholds of sensation were evaluated. Data were expressed as the mean (±SD).Results:A total of 61 children (34 males; age: 2–17 years, mean: 8.28 years) were studied. The mean resting and squeeze sphincter pressures were 83.43 (±23.23) mmHg and 191 (±64.21) mmHg, respectively. The mean length of the anal canal was 2.62 (±0.68) cm and correlated with age (r = 0.49, p < 0.0001). The mean rectal balloon volume to elicit recto‐anal inhibitory reflex was 15.66 (±10.9) cc. The first sensation, urge and discomfort were observed at 24.42 (±23.98) cc, 45.91 (±34.55) cc and 91.58 (±50.17) cc of the balloon volume, respectively. The mean resting pressure of the puborectalis muscle was 71.54 (±14.58) mmHg while the mean squeeze pressure was 134.10 (±35.2) mmHg. A positive correlation between age and balloon volume needed to elicit discomfort was determined (r = 0.49, p < 0.001).Conclusion:Normative data of 3D HRAM in children without symptoms arising from the lower gastrointestinal tract were established. There were no significant differences in pressure results between males and females.
PP‐14 EFFECTS OF BODY MASS INDEX ON GASTRIC MOTILITY IN CHILDREN WITH ABDOMINAL PAIN‐PREDOMINANT FUNCTIONAL GASTROINTESTINAL DISORDERS
Authors: Karunanayake Amaranath , Devanarayana Niranga Manjuri , Rajindrajith Shaman 
Published: September 2015

Introduction:There is evidence that overweight children have a higher prevalence of functional gastrointestinal disorders (FGIDs) than normal‐weight children. Objective of this study was to assess the effects of body mass index (BMI) on gastric motility abnormalities in children with abdominal pain‐predominant FGIDs (AP‐FGIDs).Methods:Gastric motility parameters of 100 children with AP‐FGIDs (61(61%) girls, mean age 8.0 years [SD 2.1years] and 50 healthy controls (30 (30%) boys, mean age 8.6 years [SD 1.9 years]) were assessed at the Gastroenterology Research Laboratory of Faculty of Medicine, University of Kelaniya, Sri Lanka, using a previously validated ultrasound method. AP‐FGIDs were diagnosed using Rome III criteria. Fifty‐four had functional abdominal pain, 23 had irritable bowel syndromes, 9 had functional dyspepsia, 8 had abdominal migraine and 6 had more than one AP‐FGID.Results:Patients with AP‐FGIDs had significantly lower gastric emptying rate (44.9% vs. 59.5% in controls, p < 0.0001), frequency of antral contractions (8.29 vs. 9.44, p < 0.0001), amplitude of antral contraction (48.6% vs. 58.1%, p < 0.0001) and antral motility index (4.0 vs. 6.4, p = 0.001). Fasting antral size (FA) and antral area at 1minute (AA1) and antral area at 15 minutes (AA15) after ingestion of the liquid test meal were not significantly different. BMI of children with AP‐FGIDs and controls were respectively 15.2 and 15.6 (p = 0.42). The correlations between BMI and AA1 (r = 0.29, p = 0.007), AA15 (r = 0.32, p = 0.003) and MI (r = 0.22, p = 0.038) in children with AP‐FGIDs were significant. Patients with BMI <15Kg/m2 had a lower FA (1.5cm2 vs. 2.1cm2, p = 0.03), AA1 (8.9 cm2 vs. 10.7 cm2, p = 0.003) and AA15 (4.6 cm2 vs. 5.8 cm2, p = 0.01) than patients with BMI >15Kg/m2.Conclusions:BMI has an impact on certain gastric motility parameters in children with AP‐FGIDs. However, it does not contribute to abnormalities seen in main gastric motility parameters such as gastric emptying.
Arthroscopic Treatment of Septic Arthritis in Very Young Children
Authors: Thompson Rachel M. , Gourineni Prasad 
Published: September 2015

Introduction:
Arthroscopic lavage is a well-established, minimally invasive treatment for septic arthritis (SA) in adults, but the use of arthroscopy in the pediatric population is typically restricted to sports injuries and deformity. Previous research on arthroscopic lavage of septic joints in the pediatric population has been limited to case reports and small case series of older children. As such, we aimed to evaluate the safety and efficacy of arthroscopic treatment of SA in various joints in very young children.

Methods:
Between 2011 and 2015, 24 children (aged 3 wk to 6 y) were treated for SA with arthroscopic lavage. A single portal was adequate for both inflow and outflow in most cases. A second portal was used in all knees and in other joints for synovectomy, when indicated. Drains were placed through the portal site and remained in place for 2 to 3 days. Antibiotics were managed by the infectious disease service.

Results:
Nine hips, 9 knees, 4 ankles, and 2 shoulders were included. Portal placement, visualization, and adequate lavage were straight forward in all joints. There was 1 transient femoral nerve palsy and no other arthroscopy-associated complications (iatrogenic damage, difficult drain placement, or conversion to open). Two patients required repeat arthroscopic lavage for disease eradication, one of which required a second admission. A third patient underwent open irrigation following arthroscopic lavage with a resultant 1.125 average procedures per subject. At final follow-up (2 to 49 mo, average 16 mo), no recurrence of infection or decreased range of motion was noted.

Conclusions:
Arthroscopic lavage appears to be a safe, quick, and effective alternative to open arthrotomy for the treatment of SA in very young children. It is feasible in any large joint even in the infantile population, allowing for improved visualization and irrigation with little soft-tissue dissection and morbidity. Our relatively simple technique and positive results should encourage regular use of arthroscopic treatment of SA even in very young children.

Level of Evidence:
Level IV—case series.
A Serial Multiplex Immunogold Labeling Method for Identifying Peptidergic Neurons in Connectomes
Authors: Shahidi Réza , Williams Elizabeth A. , Conzelmann Markus , Asadulina Albina , Verasztó Csaba , Jasek Sanja , Bezares-Calderón Luis A. , Jékely Gáspár 
Published: September 2015

ABSTRACTElectron microscopy-based connectomics aims to comprehensively map synaptic connections in neural tissue. However, current approaches are limited in their capacity to directly assign molecular identities to neurons. Here, we use serial multiplex immunogold labeling (siGOLD) and serial-section transmission electron microscopy (ssTEM) to identify multiple peptidergic neurons in a connectome. The high immunogenicity of neuropeptides and their broad distribution along axons, allowed us to identify distinct neurons by immunolabeling small subsets of sections within larger series. We demonstrate the scalability of siGOLD by using 11 neuropeptide antibodies on a full-body larval ssTEM dataset of the annelidPlatynereis. We also reconstruct a peptidergic circuitry comprising the sensory nuchal organs, found by siGOLD to express pigment-dispersing factor, a circadian neuropeptide. Our approach enables the direct overlaying of chemical neuromodulatory maps onto synaptic connectomic maps in the study of nervous systems.
Assessing organizational innovativeness – evidence from corporate narratives
Authors: Ackermann Malte Stefan , Stephan Michael , Penrose John M. 
Published: September 2015

Purpose– The purpose of this paper is twofold: to quantify the communication of organizational innovativeness (OI) on a large scale; and to examine the relationship of communicating OI and the corresponding investments in research and development (R & D) of multinational corporations (MNCs).Design/methodology/approach– In total, 3,043 annual reports from 326 MNCs are examined utilizing quantitative content analysis, which focusses on fixed selected terminologies, in the years 1998-2008.Findings– Scholars assume that the capacity for OI is becoming the single most important task in organizational survival. Even though in the sample the investments in R & D are not increasing, even slightly declining, the communication of OI is increasing. Using mixed-effects regression analysis, the findings indicate that the corporations that are investing in R & D are also communicating these efforts correspondingly.Practical implications– This is the first study that measures the communication of OI using quantitative content analysis.Originality/value– The results indicate that not only do the communication efforts of an organization’s OI have a perceived increasing importance. They also suggest that OI itself has become more important for organizations from a strategic point of view.
Engaging employees in China
Authors: Men Linjuan Rita , Hung-Baesecke Chun-ju Flora 
Published: September 2015

Purpose– Academics and professionals across management and communication fields have increasingly recognized significant contributions of engaged employees to organizations. The purpose of this paper is to investigate the effect of communication channels, and communication attributes of transparency and authenticity on employee engagement in China.Design/methodology/approach– A web survey was conducted with 407 employees randomly selected from a variety of medium-sized and large corporations in China.Findings– The study results show that face-to-face interactions and social media are the most effective channels in building organizational transparency, authenticity, and engaging employees in China. Organizational transparency and authenticity demonstrate strong positive effects on employee engagement. Theoretical and practical implications are discussed.Originality/value– This study was among the first empirical attempts to examine the impact of corporate communication channels on employee engagement in China. It also contributes to the growing literature on corporate transparency and authenticity, two of the major communication trends identified in the twenty-first century.
It's not just a cup of “tea”: building consumer brand relationship
Authors: Kamath Renuka , Aggarwal Ashita 
Published: September 2015

Subject area
Marketing management, brand management, brand loyalty, brand consumer behavior.

Study level/applicability
MBA program or the Executive Education program.

Case overview
Anubhav Jain, Marketing Head of Digamber Industries, is concerned about the national launch of Surya Gold tea. The brand had been doing well in Jabalpur (Madhya Pradesh, India) with almost 20 per cent market share. However, market reports suggested that retailers primarily pushed the brand and consumers had little loyalty for Surya Gold. Owing to lower repeat purchases, Jain had to spend large amount of money on consumer acquisition. For the national launch, a large base of loyal consumers was critical for business growth. He understood brand loyalty but found it a difficult proposition to relate from consumers' perspective. Market consultants were hired to conduct a qualitative research based on Susan Fournier's work on consumer-brand relationships. The case gives an account of conversations with professed lovers of tea to understand consumer behavior toward tea, including why people drink tea, how they choose their brands and what makes them re-buy or change brands. The case makes certain propositions around brand loyalty, which Jain had to decode to understand tea consumers in India, how brand loyalty develops and changes over time, and hence, how should he plan his marketing strategy. The case attempts to help students critique traditional definitions of brand loyalty, understand and evaluate the concept from consumers' perspective and highlight its importance in marketing strategy planning by explaining evolution, various types and intensity of brand loyalty.

Expected learning outcomes
The broad objective of the case is to strengthen participants' understanding of brand loyalty concept and also appreciate the importance and role of brands in consumer's life. The case can be used for MBA or executive education in brand management or consumer behavior courses. The specific objectives of this case are to help students appreciate the variations in brand loyalty across consumers and critically assess the traditional definition of loyalty, highlight the connection between the consumer personality and the brand attributes, help them understand how the concept of brand loyalty and brand relationship affects consumers' attitude and behavior, help students understand as to why brand loyalty develops and how it can be maintained and expose students to qualitative unstructured data and give them an experience of using it for managerial use.

Supplementary materials
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