bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Psychological Factors on Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Systematic Review
Authors: Nedder Victoria J. , Raju Akash G. , Moyal Andrew J. , Calcei Jacob G. , Voos James E. 
Published: July 2024

Context: Anterior cruciate ligament (ACL) tears are a common orthopaedic injury, and the incidence of ACL reconstruction (ACLR) continues to increase. Current clinical practice guidelines (CPGs) recognize the role of psychological factors in rehabilitation, but patient-reported outcome measures (PROs) and psychological readiness are rarely incorporated into rehabilitation. Objective: The purpose of this review was to highlight the importance of psychological health after ACL injury, understand the current metrics used to monitor psychological recovery, and outline how psychological recovery can be better incorporated in current CPGs. Data Sources: A systematic review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines (PRISMA); 63 studies were identified with a PubMed search using the term “ACL Injuries/psychology”. Study Selection: Exclusion criteria included lack of consideration of psychological effects or studies validating PROs after ACLR. Studies were reviewed by multiple reviewers, and a total of 38 studies were included after applying exclusion criteria. Study Design: Systematic review. Level of Evidence: Level 3b. Data Extraction: Two independent reviewers analyzed the included articles to extract sample size, psychological readiness scale or other measures used, and key results. Results: Psychological outcomes, especially kinesiophobia and fear of reinjury, are seen commonly after ACLR. Psychological factors were shown to impede return to sport (RTS), alter measurable knee biomechanics, and potentially increase the risk for re-rupture. Targeted interventions such as kinesiotaping, knee bracing, and imagery training can help improve psychological and functional testing after ACLR. Conclusion: ACLR is often complicated by psychological factors. Psychological readiness is a crucial yet often unincorporated part of rehabilitation. Patients with higher levels of kinesiophobia and lower psychological readiness to RTS specifically should be identified to allow for administration of interventions, such as imagery training, knee bracing, or kinesiotaping, that can mitigate the negative effects of psychological outcomes and improve recovery.
Critical Policy Analysis of the Second Round of the Double First-Class Project in China
Authors: Zheng (郑高明) Gaoming , Li (李维维) Weiwei 
Published: July 2024

Purpose This critical policy analysis aims to comprehensively examine the second round of China's first-class discipline development project, commonly known as the “Double First-Class Project” (DFC Project or Shuang Yi Liu Project). Design/Approach/Methods We conducted desk research between May 2022 and December 2023 using relevant policy documents, academic literature, news sources, and commentaries that specifically focused on the second round of the DFC Project in China. Employing a critical policy analysis approach, we analyzed the gathered data from three key perspectives: policy as text, policy as discourse, and policy effects (including both first- and second-order effects). Findings The second round of the DFC Project was implemented within the context of strengthened state regulation, prevalent managerialism, and an emphasis on promoting education equality in China's higher education development. A notable shift in structural dynamics occurred between the first and second round. These include the possibility of universities being added to or removed from the official list, increased academic autonomy for selected universities, and the promotion of interdisciplinary research within specific institutions. The implementation of the second round of the DFC Project reflects China's commitment to developing an internationalization strategy with Chinese characteristics. This strategy aims to align with China's national strategic needs and position the country as a cooperative partner, promoter, competitor, and potential leader in global scholarship. Originality/Value By employing a critical policy analysis approach, this study offers a comprehensive examination of the second round of the DFC project in China, contributing to existing knowledge on the development of world-class university policies in the country.
The rules of T-cell engagement: current state of CAR T cells and bispecific antibodies in B-cell lymphomas
Authors: Haydu J. Erika , Abramson Jeremy S. 
Published: July 2024

Abstract
T-cell engaging–therapies have transformed the treatment landscape of relapsed and refractory B-cell non-Hodgkin lymphomas by offering highly effective treatments for patients with historically limited therapeutic options. This review focuses on the advances in chimeric antigen receptor–modified T cells and bispecific antibodies, first providing an overview of each product type, followed by exploring the primary data for currently available products in large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma. This review also highlights key logistical and sequencing considerations across diseases and product types that can affect clinical decision-making.
Failure Analysis of Dissimilar Metal Welds between Ferritic Heat Resistant Steels and Austenitic Stainless Steels in Power Plant
Authors: Li Xiaogang , Nie Junfeng , Wang Xin , Li Kejian , Zhang Haiquan 
Published: July 2024

AbstractThis study analysed the failure of dissimilar metal welds (DMWs) between ferritic heat resistant steels and austenitic stainless steels and investigated its influencing factors by means of numerical simulation, microstructure characterization and mechanical property test. Under the long-term high-temperature service condition in practical power plant, the DMW failure mode was along the interface between nickel-based weld metal (WM) and ferritic heat resistant steel, and the failure mechanism was stress/strain concentration, microstructure degradation and oxidation coupling acting on the interface. The numerical simulation results show that interface stress/strain concentration was due to the differences in coefficient of thermal expansion and creep strength, and the degree of stress/strain concentration was related to service time. The ferrite band formed at the WM/ferritic steel interface was prone to cracking, attracting the fracture along the interface. The interface crack allowed oxidation to develop along the WM/ferritic steel interface. During long-term service, the interface stress/strain concentration, microstructure and oxidation all evolved, which synergistically promoted interface failure of DMW. However, only under the long-term service of low stress conditions could trigger the interface failure of DMW. Meanwhile, long-term service would reduce the mechanical strength and plasticity of DMW.
Exploring the therapeutic potential of garlic in alcoholic liver disease: a network pharmacology and experimental validation study
Authors: Gao Siqi , Gao Tingting , Li Lizheng , Wang Shule , Hu Jie , Zhang Ruijing , Zhou Yun , Dong Honglin 
Published: July 2024

AbstractObjectiveEmploying network pharmacology and molecular docking, the study predicts the active compounds in garlic and elucidates their mechanism in inhibiting the development of alcoholic liver disease (ALD). ALD is a global chronic liver disease with potential for hepatocellular carcinoma progression.MethodsThe main active ingredients and targets of garlic were identified through screening the TCMSP, TCM-ID, and ETCM databases. ALD disease targets were sourced from DisGeNET, GeneCards, and DiGSeE databases, and intervention targets for garlic were determined through intersections. Protein interaction networks were constructed using the STRING platform, and GO and KEGG pathway enrichment analyses were performed with R software. The garlic component-disease-target network was established using Cytoscape software. Validation of active ingredients against core targets was conducted through molecular docking simulations using AutoDock Vina software. Expression validation of core targets was carried out using human sequencing data of ALD obtained from the GEO database.ResultsIntegration of garlic drug targets with ALD disease targets identified 83 target genes. Validation through an alcohol-induced ALD mouse model supported certain network pharmacology findings, suggesting that garlic may impede disease progression by mitigating the inflammatory response and promoting ethanol metabolism.ConclusionThis study provides insights into the potential therapeutic mechanisms of garlic in inhibiting ALD development. The identified active ingredients offer promising avenues for further investigation and development of treatments for ALD, emphasizing the importance of botanical remedies in liver disease management.
The role of immune-inflammatory markers in children with complicated and uncomplicated malaria in Enugu, Nigeria
Authors: Ugwu Angela Ogechukwu , Chukwuanukwu Rebecca Chinyelu , Ehiaghe Friday Alfred , Ugwu Emmanuel Onyebuchi 
Published: July 2024

Abstract
Background
There is currently insufficient data regarding immune parameters and relationship with severity of malaria infection in Enugu, Nigeria where the economic and social costs of the disease and its management are extremely high. This study was conducted to determine the relationship between malaria severity and some immune-inflammatory markers among malaria-infected children in Enugu, Nigeria.

Methods
The study adopted a case control design. Eligible children were categorized into three groups — complicated, uncomplicated and healthy children. Pro-inflammatory cytokines –interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α); and anti-inflammatory cytokine — interleukin-10 (IL-10) were assayed using enzyme-linked immunosorbent assay (ELISA) technique, while immune cell ratios — neutrophil lymphocyte ratio (NLR) and monocyte lymphocyte ratio (MLR) were calculated from full blood count results.

Results
The overall mean age of the participants was 7.3 ± 3.4 (range: 6 months − 12 years) and the male-female ratio was 1:1. There was no significant difference between the ages of the three groups (P = 0.44). The Mean levels of IFN-γ, TNF-α, and NLR were higher in complicated than uncomplicated malaria (266.9 ± 66.3pg/ml vs. 62.5 ± 6.4pg/ml, p < 0.001; 140.3 ± 30.0pg/ml vs. 42.0 ± 9.0pg/ml, p < 0.001; and 32.9 ± 16.2pg/ml vs. 17.8 ± 6.0pg/ml, p < 0.001, respectively); and higher in uncomplicated malaria than healthy children (62.5 ± 6.4pg/ml vs. 40.6 ± 9.1pg/ml, p < 0.001; 42.0 ± 9.0pg/ml vs. 105.7 ± 32.1, p < 0.001; 17.8 ± 6.0pg/ml vs. 18.7 ± 6.2pg/ml, p < 0.001, respectively). On the other hand, the mean level of IL-10 is higher in uncomplicated than complicated malaria (105.73 ± 32.06pg/ml vs. 40.60 ± 9.11pg/ml, p < 0.001). There was a positive correlation between NLR and IFN-γ (r = 0.815; p = 0.003), as well as NLR and TNF-α (r = 0.745; p = 0.002).

Conclusion
Complicated malaria is associated with higher levels of pro-inflammatory cytokines while uncomplicated malaria is associated with higher levels of anti-inflammatory cytokines. NLR correlates positively with pro-inflammatory cytokines, and could be useful in evaluation for the severity of malaria infection.
Antibiotic feeding changes the bacterial community of Chilo suppressalis and thereby affects its pesticide tolerance
Authors: Xia Xue , Liu Bing-Qian , Yu Pei-Han , Yu Zheng-Ping , Zhang Ru , Luo Guang-Hua , Fang Ji-Chao 
Published: July 2024

Abstract
Background
Owing to the widespread use of chemical pesticides to control agricultural pests, pesticide tolerance has become a serious problem. In recent years, it has been found that symbiotic bacteria are related to pesticides tolerance. To investigate the potential role of microorganisms in the pesticide tolerance of Chilo suppressalis, this study was conducted.

Results
The insect was fed with tetracycline and cefixime as the treatment group (TET and CFM, respectively), and did not add antibiotics in the control groups (CK). The 16S rDNA sequencing results showed that antibiotics reduced the diversity of C. suppressalis symbiotic microorganisms but did not affect their growth and development. In bioassays of the three C. suppressalis groups (TET, CFM, and CK), a 72 h LC50 fitting curve was calculated to determine whether long-term antibiotic feeding leads to a decrease in pesticide resistance. The CK group of C. suppressalis was used to determine the direct effect of antibiotics on pesticide tolerance using a mixture of antibiotics and pesticides. Indirect evidence suggests that antibiotics themselves did not affect the pesticide tolerance of C. suppressalis. The results confirmed that feeding C. suppressalis cefixime led to a decrease in the expression of potential tolerance genes to chlorantraniliprole.

Conclusions
This study reveals the impact of antibiotic induced changes in symbiotic microorganisms on the pesticide tolerance of C. suppressalis, laying the foundation for studying the interaction between C. suppressalis and microorganisms, and also providing new ideas for the prevention and control of C. suppressalis and the creation of new pesticides.
Exogenously applied silver nanoparticles (AgNPs) differentially affect bacterial blight disease control in twenty-seven wheat cultivars
Authors: Fatemifard Seyyedeh Zahra , Masoumiasl Asad , Fazeli-Nasab Bahman , Piri Ramin , Mirzaei Ali Reza , Salehi Sardoei Ali , Ghorbanpour Mansour 
Published: July 2024

AbstractThe bacterial blight of wheat is an important global disease causing a significant decline in crop yield. Nanotechnology offers a potential solution for managing plant diseases. Therefore, this research aimed to investigate the effectiveness of silver nanoparticles (AgNPs) in controlling bacterial blight in 27 locally grown wheat cultivars. The study examined the impact of AgNPs at three distinct time points: 1, 3, and 5 days after the onset of the disease. Biochemical assay revealed that one day after applying the disease stress, the Inia cultivar had the highest amount of soluble protein (55.60 μg.g−1FW) content in the treatment without AgNPs. The Azadi cultivar, without AgNPs treatment, had the lowest amount of soluble protein content (15.71 μg.g−1FW). The Tabasi cultivar had the highest activity of the superoxide dismutase (SOD) (61.62 mM.g−1FW) with the combination treatment of AgNPs. On the other hand, the Karchia cultivar had the lowest SOD activity (0.6 mM.g−1FW) in the treatment of disease without AgNPs. Furthermore, three days after the application of stress, the Mahdavi cultivar had the highest amount of soluble protein content (54.16 μg.g−1FW) in the treatment of disease without AgNPs. The Niknejad cultivar had the highest activity of the SOD (74.15 mM.g−1FW) with the combined treatment of the disease without AgNPs. The Kavir cultivar had the lowest SOD activity (1.95 mM.g−1FW) and the lowest peroxidase (POX) activity (0.241 mM g−1FW min−1) in the treatment of the disease with AgNPs. Five days after exposure to stress, the Mahooti cultivar had the highest SOD activity (88.12 mM.g−1FW) with the combined treatment of the disease with AgNPs, and the Karchia cultivar had the lowest SOD activity (2.39 mM.g−1FW) in the treatment of the disease with AgNPs. Further, the results indicated that exposure to AgNPs could improve the antioxidant properties of wheat seeds in blight-infected and disease-free conditions in some cultivars.
Unexplained colonic necrosis in a patient with end-stage kidney disease on chronic hemodialysis: case report and review of uremic colitis
Authors: Zhou Jing , Zeng Yisen , Zhou Xiaoying , Liu Yong 
Published: July 2024

Abstract
Background
Intestinal necrosis in uremic patients has been reported but is rare.

Case presentation
A 56-year-old male patient who underwent long-term regular haemodialysis was admitted to the hospital due to involuntary shaking of the limbs and nonsense speech. The patient’s symptoms improved after continuous blood purification under heparin anticoagulation, rehydration, sedation, and correction of electrolyte disturbances. However, the patient experienced a sudden onset of abdominal pain and a rapid decrease in blood pressure; high-dose norepinephrine were required to maintain his blood pressure. A plain abdominal radiograph performed at bedside showed intestinal dilation. Colonoscopy revealed inflammation and oedema of the entire colon, with purulent secretions and multiple areas of patchy necrosis. The cause of intestinal ischaemia was not clear.

Conclusions
Although rare, previous causes of uremic colitis have been reported. As the patient developed abdominal pain before the onset of shock and the necrosis was seen on colonoscopy, we suspect that this is a case of fulminant uremic colitis.
Exploring factors associated with non-alcoholic fatty liver disease using longitudinal MRI
Authors: Horn Friedrich , Ittermann Till , Kromrey Marie-Luise , Seppelt Danilo , Völzke Henry , Kühn Jens-Peter , Schön Felix 
Published: July 2024

Abstract
Background
To identify factors associated with non-alcoholic fatty liver disease over a 5-year period.

Methods
Three hundred seven participants, including 165 women, with a mean age of 55.6 ± 12.0 years underwent continuous quantitative MRI of the liver using the proton-density fat fraction (PDFF). The liver’s fat fractions were determined at baseline and 5 years later, and the frequency of participants who developed fatty liver disease and potential influencing factors were explored. Based on significant factors, a model was generated to predict the development of fatty liver disease.

Results
After excluding participants with pre-existing fatty liver, the baseline PDFF of 3.1 ± 0.9% (n = 190) significantly increased to 7.67 ± 3.39% within 5 years (p < 0.001). At baseline, age (OR = 1.04, p = 0.006, CI = 1.01–1.07), BMI (OR = 1.11, p = 0.041, CI = 1.01–1.23), and waist circumference (OR = 1.05, p = 0.020, CI = 1.01–1.09) were identified as risk factors. Physical activity was negatively associated (OR = 0.43, p = 0.049, CI = 0.18–0.99). In the prediction model, age, physical activity, diabetes mellitus, diastolic blood pressure, and HDL-cholesterol remained as independent variables. Combining these risk factors to predict the development of fatty liver disease revealed an AUC of 0.7434.

Conclusions
Within a five-year follow-up, one-quarter of participants developed fatty liver disease influenced by the triggering factors of age, diabetes mellitus, low HDL-cholesterol, and diastolic blood pressure. Increased physical activity has a protective effect on the development of fatty liver.
Pregnancy outcomes in women with Celiac disease in Northeast Iran: a regional retrospective cohort study
Authors: Sahebdel Saeed , Ganji Azita , Nezhad Baei Sajedeh Alijan , Amirian Malihe , Farkhani Ehsan Mousa , Ebrahimi Mohammad , Nazar Eisa , Khojastehnezhad Mohammad Amin , Valizadeh Sadaf 
Published: July 2024

Abstract
Purpose
To investigate the odds and associations of pregnancy outcomes with exposure to biopsy-confirmed celiac disease (CD) in Northeast Iran.

Methods
In this regional retrospective cohort study, pregnancy records of all women with celiac disease who visited Celiac Disease Clinic of Imam-Reza Hospital from 2017 to 2023 (exposed group) and a sample of women without CD (unexposed group) were extracted using the Electronic Health Record of Mashhad University of Medical Sciences called “Sina”. The unexposed group was randomly selected of the database and matched to exposed group on age, location of residence, socioeconomic factors. Our exclusion criteria included age ≥ 45, presence of concomitant disorders, history of non-obstetric uterine surgery, induction of pregnancy through assisted reproductive technology, and any concurrently ongoing pregnancy at the time of study. Pregnancy outcomes evaluated in this study included normal delivery, miscarriage, preterm labor, preeclampsia, and stillbirth. Adjusted odds ratios were calculated using logistic regression adjusted for confounders.

Results
Ninety pregnancy records of women with CD and 270 pregnancies of women without CD were included in this study. Low neonatal birthweight (i.e. under 2500 g) had no significant association with CD (aOR = 0.99, 95% CI = 0.92–1.06), as well as postpartum hemorrhage (aOR = 1.12, 95%CI = 0.91–1.38), fetal anomaly (aOR = 0.89, 95%CI = 0.69–1.15), miscarriage (aOR = 1.00, 95%CI = 0.91–1.10), ectopic pregnancy (aOR = 0.94, 95%CI = 0.73–1.20), preterm labor (aOR = 1.00, 95%CI = 0.92–1.10), gestational diabetes mellitus (aOR = 1.07, 95%CI = 0.98–1.16), gestational hypertension (aOR = 0.99, 95%CI = 0.89–1.11), and gestation hypothyroidism (aOR = 0.95, 95%CI = 0.82–1.11). However, we found significantly lower odds of preeclampsia in pregnancies affected by CD (aOR = 0.83, 95%CI = 0.69–0.99).

Conclusion
Celiac disease was not associated with increased odds of low neonatal birthweight, postpartum hemorrhage, fetal anomaly, miscarriage, ectopic pregnancy, preterm labor, gestational diabetes mellitus, gestational hypertension and gestational hypothyroidism. Preeclampsia had significantly lower odds in pregnancies affected with CD.
Trends over the past 15 years in long-term care in Switzerland: a comparison with Germany, Italy, Norway, and the United Kingdom
Authors: Lussi Clara , Bickenbach Jerome , Halvorsen Rune , Sabariego Carla 
Published: July 2024

Abstract
Background
The demographic changes affecting Switzerland and other European countries, including population ageing, will continue to challenge policymakers in building accessible, affordable, comprehensive and high-quality long-term care (LTC) systems. The purpose of this paper is to investigate how Switzerland’s LTC system compares to other European countries, in order to inform how to respond to the increasing need for LTC. We carried out a descriptive study using secondary data from key national and international organizations.

Methods
By comparing the financing, workforce, service delivery and need for LTC in Switzerland, Germany, Italy, Norway and the United Kingdom, we described similarities and differences in these five European countries between 2005-2019. Thirty-three indicators within five domains were analysed: (1) Population statistics and health expenditure, (2) Need for LTC, (3) LTC financing, (4) LTC service delivery, and (5) LTC workforce.

Results
Switzerland has the highest life expectancy in comparison to the other four high-income countries. However, similarly to other countries, the years lived with disability are increasing in Switzerland. Switzerland’s public expenditure on LTC as a share of GDP is lower than that of Norway and Germany, yet out-of-pocket expenditure on LTC is highest in Switzerland. Switzerland has the highest proportion of persons receiving formal LTC both in institutions and at home. Switzerland has had the most pronounced increase in the proportion of over 65-year-olds receiving LTC at home. Even though more than fourfold more persons receive care at home, Switzerland still has more workforce in LTC institutions than in home-care. In comparison to Germany and the UK, Switzerland has a lower number of informal carers as a proportion of 50-year-olds and over, as well as fewer nationally available services for informal carers compared to Germany, Italy, Norway and the UK.

Conclusions
Our comparative study corroborates the importance of improving the affordability of LTC, continuing to support the movement towards home care services, improving the support given to both the professional workforce and informal carers, and improving the amount and quality of LTC data. It also provides a valuable contrast to other European countries to support evidence-informed policymaking.