bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of a Citrate-Based Protocol for Sustained Low-Efficiency Dialysis in AKI Using Standard Dialysis Equipment
Authors: Fiaccadori Enrico , Regolisti Giuseppe , Cademartiri Carola , Cabassi Aderville , Picetti Edoardo , Barbagallo Maria , Gherli Tiziano , Castellano Giuseppe , Morabito Santo , Maggiore Umberto 
Published: August 2013

Summary

Background and objectives
A simple anticoagulation protocol was developed for sustained low-efficiency dialysis (SLED) in patients with AKI, based on the use of anticoagulant citrate dextrose solution formulation A (ACD-A) and standard dialysis equipment. Patients’ blood recalcification was obtained from calcium backtransport from dialysis fluid.

Design, setting, participants, & measurements
All patients treated with SLED (8- to 12-hour sessions) for AKI in four intensive care units of a university hospital were studied over a 30-month period, from May 1, 2008 to September 30, 2010. SLED interruptions and their causes, hemorrhagic complications, as well as coagulation parameters, ionized calcium, and blood citrate levels were recorded.

Results
This study examined 807 SLED sessions in 116 patients (mean age of 69.7 years [SD 12.1]; mean Acute Physiology and Chronic Health Evaluation II score of 23.8 [4.6]). Major bleeding was observed in six patients (5.2% or 0.4 episodes/100 person-days follow-up while patients were on SLED treatment). Citrate accumulation never occurred, even in patients with liver dysfunction. Intravenous calcium for ionized hypocalcemia (< 3.6 mg/dl or < 0.9 mmol/L) was needed in 28 sessions (3.4%); in 8 of these 28 sessions (28.6%), low ionized calcium was already present before SLED start. In 92.6% of treatments, SLED was completed within the scheduled time (median 8 hours). Interruptions of SLED by impending/irreversible clotting were recorded in 19 sessions (2.4%). Blood return was complete in 98% of the cases. In-hospital mortality was 45 of 116 patients (38.8%).

Conclusions
This study protocol affords efficacious and safe anticoagulation of the SLED circuit, avoiding citrate accumulation and, in most patients, systematic calcium supplementation; it can be implemented with commercial citrate solutions, standard dialysis equipment, on-line produced dialysis fluid, and minimal laboratory monitoring.
Albuminuria and Cognitive Decline in People with Diabetes and Normal Renal Function
Authors: Barzilay Joshua I. , Lovato James F. , Murray Anne M. , Williamson Jeff , Ismail-Beigi Faramaz , Karl Diane , Papademetriou Vasilios , Launer Lenore J. 
Published: August 2013

Summary

Background and objectives
Diabetes mellitus is associated with increased risk of cognitive impairment. This study examines whether microvascular disease, as measured by albuminuria and decline in estimated GFR (eGFR), is associated with cognitive decline during 3.3 years of follow-up in individuals with diabetes with a normal baseline eGFR (approximately 90 ml/min per 1.73 m2).

Design, setting, participants, & measurements
Participants were from the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes study (N=2977; mean age 62.5±5.8 years; recruitment from August 2003 to December 2005, followed through June 2009), which examined the association of intensive versus standard glucose control on cognitive function. Participants underwent three neuropsychologic tests at baseline, 20 months, and 40 months. Tests included information processing speed, verbal memory, and executive function. Mixed-effects models were used to assess the association of albuminuria and eGFR on the percentage decline in each test.

Results
Participants with albuminuria at baseline and follow-up (persistent albuminuria) (−5.8% [95% confidence interval (CI), −7.3 to −4.2]) and participants with albuminuria at follow-up but none at baseline (progressive albuminuria) (−4.1% [95% CI, −5.6 to −2.7]) had greater percentage declines on information processing speed than participants without albuminuria at baseline and at follow-up (no albuminuria) (−2.6% [95% CI, −3.4 to −1.9]) (P=0.001 and P=0.10, respectively). There were borderline percentage changes in the test of verbal memory (4.8% [95% CI, 2.4 to 7.1] and 4.7% [95% CI, 2.5 to 7.0] versus 7.1% [95% CI, 6.0 to 8.3]; P=0.11 and P=0.08, respectively). On logistic regression analysis, persistent albuminuria (odds ratio, 1.37 [95% CI, 1.09 to 1.72]) and progressive albuminuria (odds ratio, 1.25 [95% CI, 1.02 to 1.56]) were associated with a ≥5% decline in information processing speed scores but not with verbal memory or executive function performance. A 1 ml/min per 1.73 m2 per year eGFR decline had a borderline association with decline in tests of cognitive function.

Conclusions
Persistent albuminuria and progressive albuminuria are associated with a decline in cognitive function in relatively young individuals with diabetes with unimpaired eGFR. These findings do not rule out the possibility of other processes causing cognitive decline.
Residual β-Cell Function 3–6 Years After Onset of Type 1 Diabetes Reduces Risk of Severe Hypoglycemia in Children and Adolescents
Authors: Sørensen Jesper S. , Johannesen Jesper , Pociot Flemming , Kristensen Kurt , Thomsen Jane , Hertel N. Thomas , Kjaersgaard Per , Brorsson Caroline , Birkebaek Niels H. ,   the Danish Society for Diabetes in Childhood and Adolescence
Published: August 2013

OBJECTIVE
To determine the prevalence of residual β-cell function (RBF) in children after 3–6 years of type 1 diabetes, and to examine the association between RBF and incidence of severe hypoglycemia, glycemic control, and insulin requirements.

RESEARCH DESIGN AND METHODS
A total of 342 children (173 boys) 4.8–18.9 years of age with type 1 diabetes for 3–6 years were included. RBF was assessed by testing meal-stimulated C-peptide concentrations. Information regarding severe hypoglycemia within the past year, current HbA1c, and daily insulin requirements was retrieved from the medical records and through patient interviews.

RESULTS
Ninety-two children (27%) had RBF &gt;0.04 nmol/L. Patients with RBF &lt;0.04 nmol/L were significantly more likely to have severe hypoglycemia than patients with RBF &gt;0.04 nmol/L (odds ratio, 2.59; 95% CI, 1.10–7.08; P &lt; 0.03). HbA1c was significantly higher in patients with RBF &lt;0.04 nmol/L compared with patients with RBF &gt;0.04 nmol/L (mean, 8.49 ± 0.08% [69.3 ± 0.9 mmol/mol] vs. 7.92 ± 0.13% [63.1 ± 1.4 mmol/mol]; P &lt; 0.01), and insulin requirements were significantly lower in patients with RBF &gt;0.2 nmol/L (mean ± SE: 1.07 ± 0.02 vs. 0.93 ± 0.07 units/kg/day; P &lt; 0.04).

CONCLUSIONS
We demonstrated considerable phenotypic diversity in RBF among children after 3–6 years of type 1 diabetes. Children with RBF are at lower risk for severe hypoglycemia, have better diabetes regulation, and have lower insulin requirements compared with children without RBF. There appears to be a lower limit for stimulated RBF of ∼0.04 nmol/L that confers a beneficial effect on hypoglycemia and metabolic control.
Digital Infrared Thermal Imaging Following Anterior Cruciate Ligament Reconstruction
Authors: Barker Lauren E. , Markowski Alycia M. , Henneman Kimberly 
Published: August 2013

This case describes the selective use of digital infrared thermal imaging for a 48-year-old woman who was being treated by a physical therapist following left anterior cruciate ligament (ACL) reconstruction with a semitendinosus autograft. J Orthop Sports Phys Ther 2012;42(3):292. doi:10.2519/jospt.2012.0405
Impaction Fracture of the Medial Femoral Condyle
Authors: Mabry Lance M. , Ross Michael D. , Abbott Jessica L. 
Published: August 2013

The patient was a 20-year-old man who sustained a noncontact left knee hyperextension injury while playing soccer. In reviewing left knee radiographs that had previously been interpreted as normal, the physical therapist noted an abnormally deep depression of the medial condylopatellar sulcus, which was concerning for a possible impacted osteochondral fracture. After discussing the radiographic findings with a radiologist, the physical therapist ordered magnetic resonance imaging, which revealed a focal indentation of the anterior portion of the medial femoral condyle with adjacent bone marrow edema that was consistent with an impaction fracture of the medial femoral condyle. J Orthop Sports Phys Ther 2013;43(7):512. doi:10.2519/jospt.2013.0413
Method for Estimation of Calcium Carbonate in Soils from Iraq
Authors: Kassim Jabbar K 
Published: August 2013

Attempts have been made to evaluate four methods of quantitative determination of soil carbonates. Calcium carbonates equivalent were determined by the acid neutralization, calcimeter and acetic acid methods. Also, it obtains by the fourth methods when the acid neutralization method is corrected against proton adsorption. The acid neutralization method gave significantly higher estimates of total carbonates and different from each of the others. The calcimeter method gave the lower estimates of CaCO3 equivalent. The results showed that the corrected values of CaCO3 equivalent did not differ significantly from other three methods but the overall mean tended to be higher than the acetic acid and calcimeter methods. It may be concluded that the acetic acid method is simple, can reasonably estimate the carbonate content and requires only a pH meter. It can be used for routine determination of soil carbonate. DOI: http://dx.doi.org/10.3126/ije.v1i1.8524 International Journal of Environment Vol.1(1) 2013: 9-19
Artisanal Fisheries in Zimbabwe: Options for Effective Management
Authors: Mhlanga Wilson , Mhlanga Lindah 
Published: August 2013

The small-scale (artisanal) fisheries in Zimbabwe play an important role in income-generation and food security at the household level. This sector has the potential to significantly increase its contribution to household income and food security if more effective fisheries management strategies are put in place. Historically, fisheries management has adopted a centralised “Top-down” approach. This approach has had very limited effectiveness. Over the last decade, efforts have been made to implement co-management in the fisheries sector. Several factors have hampered the success of fisheries co-management in the artisanal fishery. These factors have been institutional, ecological, human and financial. This paper discusses these factors and proposes possible solutions. A more innovative and effective fisheries management approach is also proposed. DOI: http://dx.doi.org/10.3126/ije.v1i1.8526 International Journal of Environment Vol.1(1) 2013: 29-45
Tuiliers et potiers de la région toulousaine à la fin du Moyen Age.
Authors: Marandet Marie-Claude 
Published: August 2013

According to the tile-maker's statutes of Toulouse and deeds relating to them authenticated by notariés (from 1300 to 1450) we could note the pegging out and the way of appropriation of a few tueries and the rules of manufacture.
The inventory ofa tile-maker's property gave us some informations about his working stock and his products. Other inventories after a death let us corne to the conclusion that earthenware was less used than pewter and wooden dishes. It only represents 3,9 % ofthings used for cooking or table service and it seems to be used for cooking or keeping in stock. It seems to be less used in médiéval houses than it's supposed from excavating of dwellings.
Genotype and Phenotype Concordance for Pharmacogenetic Tests Through Proficiency Survey Testing
Authors: Wu Alan H. B. 
Published: August 2013

Context.—Pharmacogenetic testing is becoming increasingly important for drugs such as irinotecan, warfarin, clopidogrel, codeine, and the tricyclic antidepressant drugs. Laboratories certified to perform pharmacogenetic testing must demonstrate successful performance on proficiency testing surveys.
Objectives.—To examine the performance of laboratories subscribing to pharmacogenetic proficiency testing surveys for genes that encode CYP2C9, VKORC1, UGT1A1, CYP2C19, and CYP2D6.
Data Sources.—College of American Pathologists Pharmacogenetic Proficiency Survey (PGX), 2007–2011.
Conclusions.—For all 5 genes challenged, there was good performance among participating laboratories for reporting wild types (95.4%–99.1% correct). For CYP2C9, VKORC1, and UGT1A1, there was no statistical difference in the percentage correctly detected for variant alleles compared to wild type. For CYP2C19, participating laboratories were greater than 90% successful in detecting variant genotypes of *1/*2, *1/*8, and *2/*3. However, several laboratories failed to detect *2/*2, *2/*4 and *1/*17 variant genotypes. For CYP2D6, laboratories were successful in detecting the most important variant genotypes (*1/*4, *1/*2, *4/*10, *10/*10, *2/*4, *2/*10) but not some of the less frequently encountered variant genotypes (*1/*10, *2/*3, *1/*35, *4/*5, and *1/*1XN). The interpretation of phenotypes by participating laboratories was largely consistent with the genotypes reported, with errors in genotyping leading to errors in phenotype assignment. Improvements in genotyping accuracy are needed for some pharmacogenetics laboratories with reference to CYP2C19 and CYP2D6.
Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital
Authors: Baker Gabrielle M. , Selim M. Angelica , Hoang Mai P. 
Published: August 2013

Context.—Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from these adnexal structures are, not surprisingly, found in the vulva. However, their incidence occurring in the vulva has not been reported, to our knowledge.Objective.—To determine the incidence of various vulvar adnexal lesions.Design.—We performed a retrospective review (1978–2010) of the cases at our institution.Results.—A total of 189 vulvar adnexal lesions were identified. Most of these lesions were benign (133 of 189; 70%), with hidradenoma papilliferum being the most common, followed by syringoma and various types of cysts. Rare cases of tubular adenoma, poroma, spiradenoma, hidradenoma, cylindroma, sebaceoma, and trichoepithelioma were identified. Malignant adnexal neoplasms comprised the remaining 30% (56 of 189) of the cases. Extramammary Paget disease was the most common (49 of 56), and 29% (14 of 49) demonstrated an invasive component. Rare cases of basal cell carcinoma, sebaceous carcinoma, apocrine carcinoma, adenoid cystic carcinoma, and spiradenocarcinoma were identified.Conclusions.—In this retrospective review, we identified several benign entities that have not been previously reported on the vulva, namely pilomatricoma, poroma, spiradenoma, and sebaceoma. Hidradenoma papilliferum and extramammary Paget disease were the most common benign and malignant adnexal neoplasms, respectively. The spectrum of various vulvar adnexal lesions appears to reflect the frequency of the underlying glandular elements.
Are Exact Calculation and Computational Estimation Categorically Different?
Authors: Liu Fuchang 
Published: August 2013

SummaryThis study examined, through the problem‐size effect, whether exact calculation and computational estimation are categorically different. In Experiment 1, 26 teacher candidates, most of whom were female, Caucasian, and in their early 20s, estimated 27 randomly generated double‐digit multiplication problems. In Experiment 2, 44 similar participants estimated and calculated a common set of double‐digit multiplication problems. Analysis of reaction times and error rates indicates that the problem‐size effect holds true for exact calculation but not for estimation. In estimation, as problem size increases, reaction times do not increase, nor does the rate of unreasonable estimates. Instead, the difference between a factor's unit digit and the nearest ten to be rounded to was a primary contributor to the variance of reaction times. It is concluded that exact calculation and computational estimation are computationally, cognitively, and structurally different processes. Furthermore, it is suggested that estimation skills be given separate, dedicated attention in schools. Copyright © 2013 John Wiley & Sons, Ltd.
Timing of diagnosis of patients with pompe disease: Data from the pompe registry
Authors: Kishnani Priya S. , Amartino Hernán M. , Lindberg Christopher , Miller Timothy M. , Wilson Amanda , Keutzer Joan ,   on behalf of the Pompe Registry Boards of Advisors
Published: August 2013

AbstractDiagnostic delays in Pompe disease are common. The diagnostic gap (the time from the onset of symptoms to the diagnosis of Pompe disease) and factors associated with diagnostic delays were examined among Pompe Registry patients in three onset categories: Group A, onset ≤12 months of age with cardiomyopathy; Group B, onset ≤12 months without cardiomyopathy and onset >12 months to ≤12 years; and Group C, onset >12 years. Of 1,003 patients, 647 were available for analysis. In all groups, musculoskeletal signs and symptoms were among the most frequent presenting signs and symptoms, in addition to cardiomyopathy in Group A, which was part of the group's definition. Diagnostic gaps existed in all three groups. Patients presenting with respiratory and musculoskeletal signs and symptoms concurrently had the shortest diagnostic gap, while those presenting with neither respiratory nor musculoskeletal signs and symptoms had the longest. Independent factors influencing the probability of a long diagnostic gap included presenting signs and symptoms (all three groups) and year of diagnosis and age at symptom onset (Groups B and C). Group B, which represents the infantile patients without cardiomyopathy and juvenile Pompe cases, had the longest median gap (12.6 years). Diagnostic testing methods used also were reviewed. Despite the availability of blood‐based assays that can be used to quickly and accurately diagnose Pompe disease, diagnostic gaps in Pompe patients across the disease spectrum continue. © 2013 Wiley Periodicals, Inc.
Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy
Authors: Demiroz Candan , Vainshtein Jeffrey M. , Koukourakis Georgios V. , Gutfeld Orit , Prince Mark E. , Bradford Carol R. , Wolf Gregory T. , McLean Scott , Worden Francis P. , Chepeha Douglas B. , Schipper Matthew J. , McHugh Jonathan B. , Eisbruch Avraham 
Published: August 2013

AbstractBackgroundManagement of head and neck carcinoma from unknown primary (HNCUP) remains controversial, with neck dissection and radiotherapy (RT) or definitive RT both commonly used. The purpose of this study was to characterize HNCUP and retrospectively compare outcomes for patients treated with neck dissection + RT versus definitive RT.MethodsFrom 1994 to 2009, 41 patients with HNCUP underwent either neck dissection + RT (n = 22) or definitive RT ± concurrent chemotherapy (n = 19) at our institution. Treatment outcomes were compared using Kaplan–Meier methods and log‐rank test.ResultsThere were no differences between patients treated with neck dissection + RT and definitive RT in overall survival (OS), progression‐free survival (PFS), locoregional relapse‐free survival (LRFS), freedom from locoregional failure (FFLRG), or freedom from distant failure (FFDF). Among 17 patients who underwent neck dissection + RT for whom human papillomavirus (HPV) status could be determined, HPV(+) patients trended toward improved OS (p = .06) and PFS (p = .15).ConclusionNeck dissection and postoperative RT resulted in similar outcomes as definitive RT. The prognostic implications of HPV(+) nodes in HNCUP are similar to those in oropharyngeal primary cancers. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1589–1595, 2014
TNM staging compared with a new clinicopathological model in predicting oral tongue squamous cell carcinoma survival
Authors: Okuyemi Oluwafunmilola T. , Piccirillo Jay F. , Spitznagel Edward 
Published: August 2013

AbstractBackgroundThe purpose of this study was to investigate the prognostic impact of comorbidity and of demographic and pathological factors on oral tongue squamous cell carcinoma (SCC) survival, and to compare the prognostic performance of a new clinicopathological model against the routinely used TNM staging.MethodsWe conducted a retrospective study of demographic, clinical, and pathological information of 166 patients with oral tongue SCC. Cox regression was used for multivariate analysis, model building, and model discriminatory analysis.ResultsComorbidity had the most significant impact on overall survival (OS; log‐rank test, chi‐square  =  36.34; p  <  .0001). Comorbidity, tumor dimension >2 cm, and presence of extracapsular spread (ECS) or vascular invasion were independent predictors of survival. A clinicopathological model based on these 4 variables (chi‐square  =  60.23; p  <  .0001) was better (c‐statistic  =  0.736) at predicting survival compared to pathological TNM staging (c‐statistic = 0.645).ConclusionComorbidity combined with tumor dimension, ECS, and vascular invasion provide a better prediction of oral tongue SCC survival than TNM staging alone. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1481–1489, 2014
Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization
Authors: Fellmann Jonas , Weisert Jan U. , Soltermann Alex , Morand Grégoire , Morra Laura , Moch Holger , Huber Gerhard F. , Probst Rudolf 
Published: August 2013

AbstractBackgroundHelicobacter pylori is known to cause gastric cancer. Presence and carcinogenicity in the upper aerodigestive system is doubtful. This study examined the prevalence of Helicobacter pylori and related factors in biopsies from the upper aerodigestive tract (UADT) in patients with gastric colonization by Helicobacter pylori.MethodsIn a case series study, 26 patients with histopathologically confirmed gastric colonization were identified. A polymerase chain reaction (PCR) was performed on matched formalin‐fixed and paraffin‐embedded tissues of the stomach and the oral cavity, pharynx, or larynx.ResultsHelicobacter pylori was found in 38% of the samples from the oral cavity, pharynx, and larynx. An association with malignancies in these regions or possible risk factors, such as age, smoking, or alcohol, was not found.ConclusionThe upper aerodigestive system seems to be an additional reservoir in a significant percentage of patients presenting with Helicobacter pylori gastritis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1562–1566, 2014