bluuebunny/crossref_metadata_2025_split huggingface dataset:
HLA-DRB1*08:02 Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients
Authors: Furukawa Hiroshi , Oka Shomi , Shimada Kota , Sugii Shoji , Hashimoto Atsushi , Komiya Akiko , Fukui Naoshi , Miyashita Taiichiro , Migita Kiyoshi , Suda Akiko , Nagaoka Shouhei , Tsuchiya Naoyuki , Tohma Shigeto 
Published: May 2014

Background Drug-induced proteinuria can occur in rheumatoid arthritis (RA) patients treated with d-penicillamine, gold salts, or bucillamine (Buc), and represents a drug hypersensitivity reaction. Striking associations of human leukocyte antigen (HLA) alleles with adverse reactions have recently been reported for many drugs. Methods We investigated the association of HLA class II with Buc-induced proteinuria (BI-Pro) in 485 Japanese RA patients treated with Buc, of whom 25 had developed BI-Pro. Results and Conclusion This preliminary study showed a highly significant association of DRB1*08:02 with BI-Pro ( P = 1.09 × 10−6, corrected P [ Pc] = 1.96 × 10−5, odds ratio [OR] 25.17, 95% confidence interval [CI] 7.98-79.38). DQB1*04:02 was also significantly associated with increased risk of BI-Pro ( P = 2.44 × 10−5, Pc = 2.69 × 10−4, OR 10.35, 95%CI 3.99–26.83). These findings provide useful information for promoting personalized medicine for RA.
A Free Product Formula for the Sofic Dimension
Authors: Graham Robert , Pichot Mikael 
Published: May 2014

AbstractIt is proved that if G = G1 *G3G2 is free product of probability measure preserving s–regular ergodic discrete groupoids amalgamated over an amenable subgroupoid G3, then the sofic dimension s(G) satisfies the equalitywhere ℌ is the normalized Haar measure on G.
The Relationship of Self-Concept And Communication Skills Towards Academic Achievement Among Secondary School Students In Johor Bahru
Authors: Yahaya Azizi 
Published: May 2014

ABSTRACT: The purpose of this study is to examine the relationship of self-concept and interpersonal communication skills to academic achievement. 320 students from eight schools in Johor Bahru were picked at random using the simple random method. The assessment instruments used in this study were the “Tennessee Self-Concept Scale” (TCS) and the Malay version of “Interpersonal Communication Skills Inventory” (ICSI). The reliability level of the assessment instruments was 0.7498(TSCS) and 0.7587 from the pilot study done on a group of twenty respondents. The data was analyzed using the Pearson’s correlation and descriptive statistics. The students’ levels of self-concept and interpersonal communication skills were identified. The levels of students’ self-concept were positive, average or negative while the student’s interpersonal skills were high, average or low. The students’ PMR examination results were used as the academic achievement indicator. The results indicated that the majority of the students possessed the average level of self-concept and interpersonal communication skills. Self-concept was found to correlate quite significantly with interpersonal communication skills but it was found that self-concept does not correlate significantly with academic achievement. Suggestions were put forth to improve the students’ interpersonal communication skills and their self-concept. One of the suggestions is that communication skills should be introduced as a subject in the school curriculum from the primary level. This will not only develop a student’s self-confidence but also enhance his self-concept. (Keyword: self-concept, interpersonal, communication skills and academic achievement)
Les je(ux) de partitions d’Assia Djebar : un Quatuor algérien pour corps féminins
Authors: Laghouati Sofiane 
Published: May 2014

L’amour, la fantasia (1985), Ombre sultane (1987) et Vaste est la prison (1994) sont les trois premiers opus d’une tétralogie, toujours en devenir, de l’écrivaine algérienne Assia Djebar. Ils s’inscrivent dans un second cycle d’oeuvres, qui fascinent tant par leur architecture narrative et l’invention stylistique que par la place singulière qu’elles concèdent à des corps tenus habituellement au secret, parce que féminins. Ces polygraphies des corps que propose l’écrivaine sont à envisager non seulement à partir des interdits desquels elles émergent — au creuset de l’histoire personnelle ou au carrefour des destinées collectives —, mais aussi pour ce qu’elles mettent en perspective.
Le corps de la filiation : répétitions et détournements de l’Histoire des femmes dans le roman Purge de Sofi Oksanen
Authors: Mavrikakis Catherine 
Published: May 2014

Cet article veut penser la place de la répétition dans la constitution d’une filiation féminine où le corps agit comme espace commun entre les générations. Le roman Purge de Sofi Oksanen, prix Femina étranger en 2010, montre que le corps des femmes a payé le prix du déroulement de l’Histoire estonienne et que c’est sur la chair féminine que s’écrivent les répétitions et bouleversements sanglants. Entre une grand-tante qui a vécu le communisme, ses humiliations et ses viols et une petite-nièce qui se prostitue en Allemagne en étant battue, maltraitée et poursuivie par des proxénètes russes, le roman établit un écho étrange. Le corps féminin pour Oksanen est pensé comme répétition mortifère. Ce sont les reprises de l’histoire qui s’inscrivent sur la vieille femme Aliide et la jeune fille Zara. Comment sortir de cette structure de domination où les corps des femmes se parlent silencieusement dans leurs souffrances ? Par quels moyens donner à Zara la possibilité de ne pas avoir le corps blessé de l’Histoire ?
Écriture et nudité. Les femmes de Nelly Arcan et de Vanessa Beecroft
Authors: Delvaux Martine 
Published: May 2014

Cet article se penche sur la question de l’image de la femme, de la femme comme image dans le regard des hommes (suivant la lecture de John Berger). L’oeuvre de la photographe italo-américaine Vanessa Beecroft et les romans de Nelly Arcan servent ici de matériaux pour réfléchir à la peau et à la nudité comme seuil de la femme-image : lieu où le regard masculin accroche, mais surface qui permet aux femmes de résister.
A Mammary Nodule Mimicking Breast Cancer
Authors: Solaini Leonardo , Bianchi Anna , Filippini Luigi , Lucini Laura , Simoncini Edda , Ragni Fulvio 
Published: May 2014

Abstract
Metastases to the breast from extramammary tumors are rare. Several clinical, radiologic, and histologic signs can help to distinguish metastases from breast primary tumors. In the present study, we present a case of a left-sided breast metastasis from renal cancer in a 44-year-old woman whose clinical presentation was a mammary nodule in the upper internal quadrant. The patient underwent quadrantectomy with sentinel lymph node biopsy. The histology revealed a clear cell carcinoma. On computed tomography scan a 5×8-cm left renal mass with pulmonary, liver, and intrapericardial nodules was found. The patient underwent palliative care and died after 4 months. Metastasis to the breast is rare, but all of those clinical, radiologic, and histologic signs more typical of extramammary malignancies should always be considered in order to choose the best treatment strategy.
Prebending of a Titanium Elastic Intramedullary Nail in the Treatment of Distal Radius Fractures in Children
Authors: Cai Haoqi , Wang Zhigang , Cai Haiqing 
Published: May 2014

Abstract
The aims of this study were to introduce a method to treat distal radius diaphyseal metaphyseal junction fractures by prebending an elastic intramedullary nail and to evaluate the factors influencing fracture apposition. Fifty-two consecutive patients (4 to 15 years old) with a distal radius diaphyseal metaphyseal junction fracture were included. The nail was inserted and advanced into the proximal radial fragment as normal. After bending the nail distally about 90° at the site predetermined to lie at the distal segment, the elastic intramedullary nail was advanced until the prebent part completely entered the marrow cavity. The fracture angular deformity was fully corrected in anterior-posterior and lateral views. The apposition rate was 90% to 100% in lateral view, &gt;50% in anterior-posterior view. The operation time was 16.73 ± 6.253 minutes. The average time of fracture healing was 5 months (range, 4–7 months). During 12 to 19 months of follow-up, firm fracture healing and good remodeling were observed, and there was no impaired forearm rotation function or secondary fracture. Our study showed the treatment of distal radius diaphyseal metaphyseal junction fractures by prebent intramedullary nail could make up for the deficiency of Kirschner wires and steel plates and keep the fracture stable. Fracture type and the anatomical features of the distal radius were associated with fracture apposition.
Outcomes Following Placement of Non–Cross-Linked Porcine-Derived Acellular Dermal Matrix in Complex Ventral Hernia Repair
Authors: Golla Dinakar , Russo Carly C. 
Published: May 2014

AbstractRepair of complex ventral hernias frequently results in postoperative complications. This study assessed postoperative outcomes in a consecutive cohort of patients with ventral hernias who underwent herniorrhaphy using components separation techniques and reinforcement with non–cross-linked intact porcine-derived acellular dermal matrix (PADM) performed by a single surgeon between 2008 and 2012. Postoperative outcomes of interest included incidence of seroma, wound infection, deep-vein thrombosis, bleeding, and hernia recurrence determined via clinical examination. Of the 47 patients included in the study, 25% were classified as having Ventral Hernia Working Group grade 1 risk, 62% as grade 2, 2% as grade 3, and 11% as grade 4; 49% had undergone previous ventral hernia repair. During a mean follow-up of 31 months, 3 patients experienced hernia recurrence, and 9 experienced other postoperative complications: 4 (9%) experienced deep-vein thrombosis; 3 (6%), seroma; 2 (4%), wound infection; and 2 (4%), bleeding. The use of PADM reinforcement following components separation resulted in low rates of postoperative complications and hernia recurrence in this cohort of patients undergoing ventral hernia repair.
Long-Term Outcomes of Laparoscopic Splenectomy Versus Open Splenectomy for Idiopathic Thrombocytopenic Purpura
Authors: Qu Yikun , Xu Jian , Jiao Chengbin , Cheng Zhuoxin , Ren Shiyan 
Published: May 2014

Abstract
The long-term outcomes of laparoscopic splenectomy (LS) versus open splenectomy (OS) in patients with idiopathic thrombocytopenic purpura (ITP) are not known. A retrospective analysis of 73 patients who underwent splenectomy (32 LS and 41 OS) for refractory ITP between April 2003 and June 2012 was conducted. LS was associated with shorter hospital stay (P = 0.01), less blood loss and blood transfusion during surgery, quicker resumption of oral diet (P &lt; 0.0001), and earlier drain removal (P &lt; 0.01). Conversion to OS was required in 4 patients (12.5%). Operation time was significantly longer in LS (P &lt; 0.0001). Deep venous thrombosis (DVT) was observed in 1 patient after LS and in 4 patients after OS (P = 0.52). One patient died from intraperitoneal bleeding after OS, another patient developed pulmonary embolism. Median follow-up of 36 months was performed in LS group (29 of 32, 91%) and of 46 months in OS group (35 of 41, 85%), 25 patients (86%) in LS group and 32 (91%) in OS group reached sustained complete response (P = 0.792). Kaplan-Meier analysis showed that there was no significant difference in the relapse-free survival rate between the groups (P = 0.777). In conclusion, the long-term outcome of laparoscopic splenectomy is not different from that of open splenectomy for patients with ITP.
Mortality Indicators and Risk Factors for Intra-Abdominal Hypertension in Severe Acute Pancreatitis
Authors: Zhao JG , Liao Q , Zhao YP , Hu Y 
Published: May 2014

Abstract
This study assessed the risk factors associated with mortality and the development of intra-abdominal hypertension (IAH) in patients with severe acute pancreatitis (SAP). To identify significant risk factors, we assessed the following variables in 102 patients with SAP: age, gender, etiology, serum amylase level, white blood cell (WBC) count, serum calcium level, Acute Physiology and Chronic Health Evaluation II (APACHE-II) score, computed tomography severity index (CTSI) score, pancreatic necrosis, surgical interventions, and multiple organ dysfunction syndrome (MODS). Statistically significant differences were identified using the Student t test and the χ2 test. Independent risk factors for survival were analyzed by Cox proportional hazards regression. The following variables were significantly related to both mortality and IAH: WBC count, serum calcium level, serum amylase level, APACHE-II score, CTSI score, pancreatic necrosis, pancreatic necrosis &gt;50%, and MODS. However, it was found that surgical intervention had no significant association with mortality. MODS and pancreatic necrosis &gt;50% were found to be independent risk factors for survival in patients with SAP. Mortality and IAH from SAP were significantly related to WBC count, serum calcium level, serum amylase level, APACHE-II score, CTSI score, pancreatic necrosis, and MODS. However, Surgical intervention did not result in higher mortality. Moreover, MODS and pancreatic necrosis &gt;50% predicted a worse prognosis in SAP patients.
Ileosigmoid Knot at Week 13 of Pregnancy: Report of a Case
Authors: Shimizu Riha , Hoshino Yoshinori , Irie Haruko , Ito Homare , Terauchi Toshiaki , Kimata Masaru , Furukawa Junji , Shinozaki Hiroharu , Kobayashi Kenji , Ogata Yoshiro 
Published: May 2014

Abstract
The ileosigmoid knot (ISK) is a rare cause of intestinal obstruction. ISK is a condition in which the ileum wraps around the base of the sigmoid colon and forms a knot, leading to high mortality with rapid progression to bowel gangrene. We herein report a rare case of ISK at week 13 of pregnancy. The ISK was diagnosed by computed tomography, and the patient underwent emergency surgery for acute abdomen. Laparotomy showed segmental gangrenous change in the sigmoid colon, which was twisted around the distal ileal loop. The gangrenous bowel was resected, and primary anastomosis was performed. To our knowledge, the present case involves the first and earliest pregnancy in which a preoperative diagnosis of ISK was made and successful treatment was performed with surgery. A radiologic approach should be undertaken for prompt diagnosis and optimal management, even in early pregnancy.
Controls on sediment production from an unpaved resource road in a Pacific maritime watershed
Authors: van Meerveld H. J. , Baird E.J. , Floyd W. C. 
Published: May 2014

AbstractUnpaved resource roads have the potential to produce large amounts of sediment and can negatively impact water quality and aquatic ecology. In order to better understand the dominant controls on sediment generation from unpaved resource roads, we did 23 large‐scale rainfall simulation experiments on a road section in the Honna Watershed, Haida Gwaii, British Columbia, Canada. The experiments were performed with different rainfall intensities (4–52 mm/h), with and without traffic. Precipitation intensity was the dominant control on the amount of sediment generated from the road surface; the total mass of sediment increased linearly with precipitation intensity. The number of passages of loaded logging trucks during an experiment was the second most dominant control on the total amount of sediment generated from the road surface. Elevated sediment concentrations in road surface runoff persisted for 30 min following the passage of loaded logging trucks during low intensity (<8 mm/h) rainfall events and for much shorter periods at higher rainfall intensities. The mass of sediment generated by the passage of a loaded truck increased with precipitation intensity. Passages of empty logging truck did not result in sediment pulses, except during very high rainfall intensities. Seven small‐scale rainfall simulation experiments on other parts of the road, however, highlight the large spatial variability in sediment production from the road surface, suggesting additional experiments are required to better describe and predict sediment production from different road sections.
OVATION Prime‐2013: Extension of auroral precipitation model to higher disturbance levels
Authors: Newell P. T. , Liou K. , Zhang Y. , Sotirelis T. , Paxton L. J. , Mitchell E. J. 
Published: May 2014

AbstractOVATION Prime (OP) is an auroral precipitation model parameterized by solar wind driving. Distinguishing features of the model include an optimized solar wind‐magnetosphere coupling function (dΦMP/dt) which predicts auroral power significantly better than Kp or other traditional parameters, the separation of aurora into categories (diffuse aurora, monoenergetic, broadband, and ion), the inclusion of seasonal variations, and separate parameter fits for each magnetic latitude (MLAT) × magnetic local time (MLT) bin, thus permitting each type of aurora and each location to have differing responses to season and solar wind input—as indeed they do. We here introduce OVATION Prime‐2013, an upgrade to the 2010 version currently widely available. The most notable advantage of OP‐2013 is that it uses UV images from the GUVI instrument on the satellite TIMED for high disturbance levels (dΦMP/dt > 1.2 MWb/s which roughly corresponds to Kp = 5+ or 6−). The range of validity is approximately 0 < dΦMP/dt ≤ 3.0 MWb/s (Kp about 8+). Other upgrades include a reduced susceptibility to salt‐and‐pepper noise, and smoother interpolation across the postmidnight data gap. The model is tested against an independent data set of hemispheric auroral power from Polar UVI. Over the common range of validity of OP‐2010 and OP‐2013, the two models predict auroral power essentially identically, primarily because hemispheric power calculations were done in a way to minimize the impact of OP‐2010s noise. To quantitatively demonstrate the improvement at high disturbance levels would require multiple very large substorms, which are rare, and insufficiently present in the limited data set of Polar UVI hemispheric power values. Nonetheless, although OP‐2010 breaks down in a variety of ways above Kp = 5+ or 6−, OP‐2013 continues to show the auroral oval advancing equatorward, at least to 55° MLAT or a bit less, and OP‐2013 does not develop spurious large noise patches. We will also discuss the advantages and disadvantages of other precipitation models more generally, as no one model fits best all possible uses.
Lake Ecosystems
Authors: Hairston Nelson G , Fussmann Gregor F 
Published: May 2014

Abstract

Lakes are bodies of nonmarine standing water connected by water flow and aerial inputs to their surrounding landscapes (watersheds). As relatively discrete ecosystems, the interplay between physical, biogeochemical and organismal processes in them is especially clear, and can be studied, understood and put to use in effective management. Sunlight penetrating from the lake surface provides energy that warms the surface water, energy for photosynthesis and an environment suitable for predators that hunt by sight. The depth to which light penetrates is determined by the amount of suspended particles (phytoplankton, organic and inorganic sediments) and coloured organic chemical compounds dissolved in the water. Important chemicals entering from the watershed include essential nutrients (chiefly phosphorus and nitrogen) and pollutants that are taken up and passed through the food chain from primary producers (phytoplankton and rooted plants) to consumers (animals that eat plants and other animals). All organisms in lakes have adaptations that affect the strengths of their interactions with their physical and biogeochemical environments and with other species in the food web. Introduced species, pollutants, and other changes in the environment result in rapid evolution of the adaptations that determine interaction strengths. These processes are particularly obvious in discrete lake ecosystems.

Key Concepts:

Lakes are relatively discrete ecosystems; the interplay between physical, biogeochemical and organismal processes in them can be easily studied.

Lakes take up a small proportion of the Earth's surface but their ecological importance is disproportionately high.

Lake ecosystems are influenced by their watersheds; a lake and its watershed are often considered to be a single ecosystem.

Thermal stratification in lakes generates vertical structure and compartments with different physical, chemical and biological properties.

The shallow‐water littoral and the open‐water pelagic are the two major horizontal zones in lakes; each zone has its characteristic food chain based on macrophytes and benthic algae or phytoplankton.

Carbon, nitrogen and phosphorus are the major nutrients affecting lakes and their watersheds as part of their biogeochemical cycles. Production is limited by phosphorus in most, but not all, lakes.

The lake sediment plays an important role as habitat for rooted plants and animals, as nutrient storage (particularly phosphorus), and as a repository of decayed material and dormant stages of lake organisms.

Both bottom‐up and top‐down processes determine the trophic structure and dynamics in lake food chains and webs.

Lake ecosystems are shaped by both ecological and evolutionary processes that occur on the same time scale.
Genetics of Pain Insensitivity
Authors: Nahorski Michael S , Emery Edward C , Woods C Geoffrey 
Published: May 2014

Abstract

Pain is a sense that has two purposes in humans: first, to warn of impending tissue damage and detect actual tissue damage – a process known as nociception; and second to guide childhood and adolescent development by setting upper limits to activity. A complete absence of pain sensing is found in a small number of Mendelian disorders. These disorders of painlessness can be categorised into three categories: defects in peripheral nervous system development, disorders in pain sensing and progressive nociceptor‐specific neuropathies. The study of these conditions has helped to sculpt our understanding of the human pain sensing systems and provided insights into the uniqueness of nociceptive neurons, with each supporting an axon/dendrite of up to 50 cm in length (which lacks a myelin sheath) and lasting a lifetime. Furthermore, these painlessness genes are starting to provide new therapeutic avenues for pain control, for example, NGF and Na
V
1.7 antagonists.

Key Concepts:

Pain is the only one of the senses ubiquitously present in all multicellular organisms.

Pain has roles in both normal development and also in the prolongation of each individual through injury avoidance and management.

Mendelian disorders of painlessness exist and are individually very rare.

The study of Mendelian disorders of painlessness has led to significant advances in our understanding of pain processing and defined a subset of genes/proteins, which are nonredundantly necessary for the generation, function and survival of nociceptors.

Biallelic mutations in either
NTRK1
or
NGF
lead to a failure of nociception system development and congenital inability to perceive pain.

Mutations in the voltage‐gated sodium channels
SCN9A
(presumably
SCN10A
) and
SCN11A
cause defective integrative pain sensing and congenital inability to perceive pain.

Degenerative disorders of nociception neurons are associated with mutations in
SPTLC1
,
SPTLC2
,
WNK1
,
FAM134B
,
IKBKAP
and
DST
and generally lead to a progressive loss of pain sensing.

New analgesic treatments are being generated from the study of Mendelian disorders of painlessness.