bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comments and illustrations of the WFUMB CEUS liver guidelines: rare benign hematological focal liver lesions (hepatic extramedullary hematopoiesis, Hemophagocytic lymphohistiocytosis, reactive lymphoid hyperplasia)
Authors: Alhyari Amjad , Safai Zadeh Ehsan , Algíbez Ana Martín , Berzigotti Annalisa , Görg Christian , Trenker Corinna , Jenssen Christian , Lim Adrian , Möller Kathleen , Dong Yi , Cui Xin Wu , Wang Wen-Ping , Dietrich Christoph Frank 
Published: August 2024

The manifestation of benign hematological infiltration in the liver is a challenge due to their rare occurrence and therefore, limited awareness and the general need for biopsy and histological confirmation. Owing to the rarity of these lesions, there are limited data concerning their appearance on ultrasound and, specifically, contrast-enhanced ultrasound. In a series of papers, we have compiled the US and CEUS characteristics of rare FLL, where there are few reports and images available, in order to build up a library of these cases. This paper describes the US and CEUS features of benign hematological FLL which include hepatic extramedullary hematopoiesis (EMH), hemophagocytic lymphohistiocytosis (HLH) and reactive lymphoid hyperplasia (RLH). Although these lesions occur rarely in the liver, their correct identification is imperative for appropriate patient`s management.
New horizons in the holographic conformal phase transition
Authors: Eröncel Cem , Hubisz Jay , Lee Seung J. , Rigo Gabriele , Sambasivam Bharath 
Published: August 2024

AbstractWe describe 5D dynamical cosmological solutions of the stabilized holographic dilaton and their role in completion of the conformal phase transition. This analysis corresponds, via the AdS/CFT dictionary, to a study of out-of-equilibrium dynamics where trajectories of the dilaton do not depend solely on thermodynamic quantities in the early universe, but have sensitivity also to initial conditions. Unlike the well-studied thermal transition, which requires quantum tunneling of an infrared brane through the surface of an AdS-Schwarzschild horizon, our approach instead invokes an early epoch in which the cosmology is fully 5-dimensional, with highly relativistic brane motion and with Rindler horizons obscuring the infrared brane at early times. In this context, we demonstrate the existence of a large class of natural initial conditions that seed trajectories where the brane simply passes through the Rindler horizon and into the basin of attraction of the stabilized dilaton potential. This corresponds to successful completion of the phase transition without sacrificing perturbativity of the 5D theory.
A thermodynamic study of $${\textbf {(2+1)}}$$-dimensional analytic charged hairy black holes with Born–Infeld electrodynamics
Authors: Sardeshpande Shravani , Daripa Ayan 
Published: August 2024

AbstractThis work presents analytical black hole solutions for a coupled Einstein–Born–Infeld–Scalar gravity system in AdS spacetime with two different non-minimal coupling functions f(z). For both solutions, we establish the regularity of the scalar field and curvature scalars outside the horizon. For one of the considered coupling cases, thermodynamic analysis in the canonical ensemble reveals stability across all temperatures, while the other case exhibits the Hawking/Page phase transition between the stable large phase of the black hole and thermal-AdS. We investigate the effect of the scalar hair parameter and black hole charge on the phase transition temperature and observe that the critical values of the scalar hair and the charge parameters constrain the feasibility of Hawking/Page phase transition.
Optical properties of a quantum dot confined in inverse square root truncated exponential potential under varied conditions of temperature, hydrostatic pressure, and electric/magnetic fields
Authors: Bayrak Kübra , Kaya Deniz , Bayrak Orhan 
Published: August 2024

AbstractIn this study, we comprehensively investigate the effects of temperature, hydrostatic pressure, linear electric, and uniform magnetic fields on the electronic and optical properties of a quantum dot confined by an inverse square root truncated exponential potential. The bound state energy eigenvalues and corresponding normalized wave functions are calculated through the numerical solution of the Schrödinger equation using the Numerov method. We formulate the effective potential, which depicts the interaction of an electron with semiconductor atoms, as a function of external parameters, including temperature, hydrostatic pressure, and electric/magnetic fields. We elucidate how variations in the effective potential, induced by changes in these external parameters, affect electronic and optical observables.
Rational singularities and q-birational morphisms
Authors: Kim Donghyeon 
Published: August 2024

In this paper, we generalize the notion of rational singularities for any reflexive sheaf of rank [Formula: see text], link our notion of rational singularities with the notion of rational singularities in, [S. Kovacs, Irrational centers, Pure Appl. Math. Q. 7(4) (2011) 1495–1515], and prove generalizations of standard facts about rational singularities. Moreover, by using a definition of non-rational locus, we introduce the notion of [Formula: see text] as a dual notion of well-known Serre’s notion of [Formula: see text], and prove a theorem about [Formula: see text]-birational morphisms.
An Empirical Study of Fault Localization on Novice Programs and Addressing the Tie Problem
Authors: Liu Yuxing , Zhong Jiaxin , Hei Qihua , Zhou Xuchuan , Xiao Jingzhong 
Published: August 2024

Programming education is becoming increasingly popular in universities. However, due to a lack of debugging experience, novices often encounter numerous difficulties in the programming process. Automatic fault localization techniques have emerged as a promising solution to address this issue. Among these techniques, Spectrum-Based Fault Localization (SBFL) and Mutation-Based Fault Localization (MBFL) have been widely used in industrial programs. However, there is a significant difference between industrial and novice programs and the performance of these methods on novice programs has not been extensively studied. To fill this gap, we conducted an empirical study to evaluate the fault localization performance and execution overhead of SBFL and MBFL in a typical novice programming environment. Our study specifically examined how different program characteristics, including code coverage and mutation score, affect the accuracy of these localization methods. Additionally, during the study, we identified the tie problem in both methods and further investigated its impact on fault localization techniques in novice programs. To remove the impact of the tie problem, we proposed using PageRank scores as weights for the suspiciousness, sorting, and locating faults based on the weighted suspiciousness. The PageRank algorithm is based on statement coverage information and constructs a directed graph. From the directed graph, a transition matrix generates the weight scores (PageRank scores) for each statement. Our research demonstrates that both SBFL and MBFL are effective for fault localization in novice programs, with MBFL showing significantly better performance in our tests. In TOP-[Formula: see text], MBFL accurately locates 67, 96 and 114 faults, respectively, indicating superior performance. Additionally, calculating weighted suspiciousness significantly alleviates the tie problem.
Discovery of a Novel Shared Variant Among RTEL1 Gene and RTEL1-TNFRSF6B lncRNA at Chromosome 20q13.33 in Familial Progressive Myoclonus Epilepsy
Authors: Chaudhari Sima , Acharya Lavanya Prakash , Jasti Dushyanth Babu , Ware Akshay Pramod , Gorthi Sankar Prasad , Satyamoorthy Kapaettu 
Published: August 2024

Background: Progressive myoclonus epilepsy (PME) is a neurodegenerative disorder marked by recurrent seizures and progressive myoclonus. To date, based on the phenotypes and causal genes, more than 40 subtypes of PMEs have been identified, and more remain to be characterized. Our study is aimed at identifying the aberrant gene(s) possibly associated with PMEs in two siblings born to asymptomatic parents, in the absence of known genetic mutations.Methods: Clinical assessments and molecular analyses, such as the repeat expansion test for CSTB; SCA1, 2, 3, 6, and 7; whole exome sequencing (WES); and mitochondrial genome sequencing coupled with computational analysis, were performed.Results: A family‐based segregation analysis of WES data was performed to identify novel genes associated with PMEs. The potassium channel, KCNH8 [c.298T>C; (p.Tyr100His)], a DNA repair gene, regulator of telomere elongation helicase 1 (RTEL1) [c.691G>T; (p.Asp231Tyr)] and long noncoding RNA, RTEL1-TNFRSF6B [chr20:62298898_G>T; NR_037882.1, hg19] were among the candidate genes that were found to be associated with PMEs. These homozygous variations in siblings belong to genes with a loss‐of‐function intolerant (pLI) score of ≤ 0.86, expected to be detrimental by multiple computational analyses, and were heterozygous in parents. Additionally, computational analysis and the expression of RTEL1 and RTEL1-TNFRSF6B revealed that RTEL1-TNFRSF6B may modulate RTEL1 via hsa‐miR‐3529‐3p. In the patient with the severe phenotype, a further deleterious mutation in SLC22A17 was identified. No de novo variants specific to these probands were identified in the mitochondrial genome.Conclusions: Our study is the first to report variants in KCNH8, RTEL1, and RTEL1-TNFRSF6B among PME cases. These genes when characterized fully may shed light on pathogenicity and have the potential to be used in the diagnosis of PME.
Innovation and Spillover Effects of Energy Demand Shocks in Belt and Road Economies
Authors: Lim King Yoong , Morris Diego 
Published: August 2024

The induced innovation hypothesis, initially proposed by Sir John Hicks, posits that as the cost of energy rises compared to other input factors, firms are motivated to engage in innovative practices to counteract the increased expenses related to energy consumption. This innovation can manifest through the development and implementation of technologies, processes, or methodologies that enhance energy efficiency or diminish overall energy dependency. In this study, we empirically examine and validate this hypothesis. By theoretically modeling how innovation responds to elevated energy costs, we exploit China’s substantial surge in energy demand as an external shock to global demand, to empirically test the predictions associated with our theoretical framework. We test these predictions using firm level data in Belt and Road Initiative (BRI) countries. Our findings strongly support the induced innovation hypothesis, revealing that, on average, a 1 percent rise in the relative cost of energy corresponds to a 2.1 to 5.1 percent increase in the likelihood of innovation in energy-exporting countries and a 0.5 to 3.6 percent increase in non-energy-exporting countries. These results are robust to various methodological variations and data restriction exercises. JEL Classification: D22, D24, O13, O14
Nonpelvic comorbid symptoms of 45 patients with pain of pelvic venous origin, before and after treatment
Authors: Smith Steven J , Smith B Holly , Sichlau Michael J , Chen Brenda , Knight Dacre , Rowe Peter C 
Published: August 2024

Objective To report the prevalence and severity of nonpelvic symptoms for patients with venous-origin chronic pelvic pain (VO-CPP) and to describe outcomes after pelvic vein stenting and embolization. Methods We retrospectively reviewed outcomes of 45 women with VO-CPP who underwent treatment with iliac vein stenting and/or embolization. Patients completed symptom-severity questionnaires before and after treatment that assessed for pelvic pain, and multiple other symptoms, including brain fog, anxiety, depression, musculoskeletal pain, fatigue, migraines and more. Results Patient age ranged from 18 to 65 years. The prevalence of common symptoms was as follows: migraines, 69%; brain fog, 76%; anxiety attacks, 58%; excess sweating, 64%; hip pain, 73%; diarrhea, 62%; constipation, 76%; and abdominal bloating, 82%. After treatment, most symptom scores improved by more than 50%; exceptions were excessive sweating (41% improvement) and bloating (47% improvement). Prevalence of individual symptoms that bundle into POTS ranged from 29% to 76%, where symptom improvement ranged from 23% to 59% after treatment. Overlapping individual symptoms characteristic of fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) were present in 64% to 82% of patients and all improved by 49% to 63% after treatment. Conclusions Pelvic venous flow abnormality is linked causally to a spectrum of interrelated symptoms, of which many can be bundled into named syndromes of unknown cause. With catheter- based treatment of pelvic venous pooling, nonpelvic symptom and syndrome scores improved.
Maybe for unbearable suffering: Diverse racial, ethnic and cultural perspectives of assisted dying. A scoping review
Authors: Bloomer Melissa J , Saffer Laurie , Hewitt Jayne , Johns Lise , McAuliffe Donna , Bonner Ann 
Published: August 2024

Background: Assisted dying, also commonly known as euthanasia and physician-assisted suicide, is legal in many countries. Interest in assisted dying is growing due to evolving societal understandings of a good death and a desire for choice. Ethico-legal perspectives are well-known, but as societies become more heterogenous, a greater understanding of the perspectives of people from diverse racial, ethnic, and cultural backgrounds is needed. Aim: To explore perspectives of people from diverse racial, ethnic and cultural backgrounds about assisted dying. Design: Scoping review with narrative synthesis. The protocol was registered with Open Science Framework. Data sources: Medline, CINAHL Complete, PsycINFO and ProQuest Dissertations & Theses Global were searched from inception to May 2023. Citations were independently assessed against inclusion and exclusion criteria. Results: Of the 17 included studies, perspectives of assisted dying were presented according to religion, religiosity, spirituality, race, ethnicity and ancestry. Perspectives were diverse, presenting more as a spectrum, with multiple intersections and interconnections. Support and/or opposition for assisted dying differed according to cultural attributes, but even amongst those with similar cultural attributes, perspectives differed according to life experiences and notions of suffering. Conclusion: Perspectives on assisted dying are dynamic and evolving. Even where assisted dying is legalised, individual’s cultural attributes contribute to unique perspectives of assisted dying as an end-of-life option. Thus, understanding a person’s culture, beliefs, expectations and choices in illness, treatment goals and care is fundamental, extending beyond what may be already considered as part of clinician-patient care relationships and routine advance care planning.
Drugs associated with reversible cerebral vasoconstriction syndrome: A pharmacovigilance study in vigiBase®
Authors: Favrelière Sylvie , Mahé Julien , Veyrac Gwenaelle , Neau Jean Philippe , Lafay-Chebassier Claire , Pérault-Pochat Marie Christine 
Published: August 2024

Background Data on drug-induced reversible cerebral vasoconstriction syndrome (RCVS) are scarce. We aimed to describe RCVS characteristics with drugs previously identified as associated with RCVS and investigate potential signals related to other drugs. Methods VigiBase® was queried for all reports of RCVS until 31 May 2023. A descriptive study was performed on reports concerning drug classes known to precipitate RCVS. To identify new drugs, a disproportionality analysis was conducted. Results In total, 560 reports were included. RCVS occurred in patients aged between 45–64 years (40%) and 18–44 years (35%), mainly in females (72.5%). Drugs were antidepressants (38.4%), triptans (6.4%), nasal decongestants (3.7%) and immunosupressants (8.7%). In 50 cases, antidepressants were in association with drugs known to precipitate RCVS. The median time to onset was 195 days for antidepressants and much shorter (1–10 days) for triptans, nasal decongestants and immunosuppressants. The outcome was favorable in 87% of cases, and fatal in 4.4%. We found a disproportionality signal with 14 drugs: glucocorticoids, bupropion, varenicline, mycophenolic acid, aripiprazole, trazodone, monoclonal antibodies (erenumab, ustekinumab and tocilizumab), leuprorelin and anastrozole. Conclusions The present study confirms the role of vasoconstrictors in the onset of RCVS, particularly when used in combination and found potential signals, which may help clinicians envisage an iatrogenic etiology of RCVS.
Thermal stability and mechanical characterization of oyster shell reinforced recycled polypropylene biocomposite
Authors: Bouiadjra Bel Abbes Bachir , Albedah Abdulmohsen , Mohammed Sohail M.A.K. , Abdo Hany S , Alothman Othman Y , Bouziane Mohammed M 
Published: August 2024

The recycling of plastics and the incorporation of bio-fillers in the plastic industry are processes currently gaining momentum due to their significance in sustainable development and carbon footprint reduction. In this investigation, a biocomposite was fabricated using recycled polypropylene (RPP) reinforced with oyster shell (OS) particles. The introduction of OS bio-fillers is aimed to mitigate plastic shrinkage during the injection molding process, with two different proportions employed: 10wt.% and 30wt.%. The biocomposite was characterized thermally and mechanically. Thermal analysis by TGA showed that the bio-fillers increased the degradation temperature of the recycled polypropylene biocomposite. Mechanical assessments demonstrated an enhancement in polypropylene stiffness by 10.4% and microhardness by 21.1%, albeit at the cost of reduced ductility. Conversely, the tensile strength and impact resistance decreased slightly with the incorporation of OS particles in RPP. Dynamic mechanical analysis indicated an improvement in the storage modulus up to 1.45 GPa of the biocomposite with the reinforcement of OS particles. These findings underscore the potential for integrating recycled polypropylene with natural reinforcements, aligning with the global pursuit of environmentally sustainable materials in diverse industrial applications.
Machine learning-based approach for predicting the compressive strength of 3D printed hexagon lattice-cored sandwich structures
Authors: Sivakumar Narain Kumar , J Kaaviya , Palaniyappan Sabarinathan , P Mohammed Azeem , Basavarajappa Santhosh , Moussa Ihab M , Ibrahim Hashem Mohamed 
Published: August 2024

The utilization of Fused Filament Fabrication (FFF) technology for developing sandwich structures proves to be an effective approach, enabling the rapid construction of intricate profiles and gaining widespread recognition for diverse structural applications. In this study, hexagon lattice-cored sandwich structures are created by situating the lattice core at the center of the PLA polymeric specimens. The performance is assessed by varying 3D-Printing Factors (3D-PFs), including Nozzle Temperature (NT), Layer Height (LH), Printing Speed (PS), and Line Width (LW). The levels of 3D-PFs are manipulated as follows: NT (180, 190, 200, 210°C), LH (0.15, 0.2, 0.25, 0.3 mm), PS (15, 20, 25, 30 mm/sec), and LW (0.1, 0.2, 0.3, 0.4 mm). By employing a FFF 3D printer, the sandwich specimens are 3D-printed and their compression properties are assessed using a Universal Testing Machine (UTM). In this research, various Machine Learning (ML) models namely Bayesian Ridge regression (BRid), Elastic Net linear regression (EN), Quantile Regression (QR), and Support Vector Machine (SVM) are utilized to predict the compressive strength/density property of the developed sandwich structure. This aids in determining the optimal levels of 3D-PFs to achieve enhanced compressive strength/density. The results reveal that the QR model, particularly when employed in the boosting ensemble technique, exhibits superior accuracy with a Root Mean Square Error (RMSE) of 0.26 × 104, Mean Absolute Error (MAE) of 0.21 × 104, and Median Absolute Error (MedAE) of 0.16 × 104. Utilizing the QR model within the boosting ensemble technique, the influence of 3D-PFs on resulting compressive strength/density is analyzed, facilitating the identification of optimized 3D-PF levels for improved compressive strength/density. Sandwich structures fabricated at these optimized levels demonstrate enhanced compressive properties, making them suitable for a variety of structural applications.
LncRNA XIST/miR-381-3P/STAT1 axis as a potential biomarker for lupus nephritis
Authors: Chen Junjie , Li Ming , Shang Shuangshuang , Cheng Lili , Tang Zhongfu , Huang Chuanbing 
Published: August 2024

Objective We aim to investigate the potential roles of key genes in the development of lupus nephritis (LN), screen key biomarkers, and construct the lncRNA XIST/miR-381-3P/STAT1 axis by using bioinformatic prediction combined with clinical validation, thereby providing new targets and insights for clinical research. Methods Gene expression microarrays GSE157293 and GSE112943 were downloaded from the GEO database to obtain differentially expressed genes (DEGs), followed by enrichment analyses on these DEGs, which were enriched and analyzed to construct a protein-protein interaction (PPI) network to screen core genes. The lncRNA-miRNA-mRNA regulatory network was predicted and constructed based on the miRNA database. 37 female patients with systemic lupus erythematosus (SLE) were recruited to validate the bioinformatics results by exploring the diagnostic value of the target ceRNA axis in LN by dual luciferase and real-time fluorescence quantitative PCR (RT-qPCR) and receiver operating characteristic (ROC). Results The data represented that a total of 133 differential genes were screened in the GSE157293 dataset and 2869 differential genes in the GSE112943 dataset, yielding a total of 26 differentially co-expressed genes. Six core genes (STAT1, OAS2, OAS3, IFI44, DDX60, and IFI44L) were screened. Biological functional analysis identified key relevant pathways in LN. ROC curve analysis suggested that lncRNA XIST, miR-381-3P, and STAT1 could be used as potential molecular markers to assist in the diagnosis of LN. Conclusion STAT1 is a key gene in the development of LN. In conclusion, lncRNA XIST, miR-381-3P, and STAT1 can be used as new molecular markers to assist in the diagnosis of LN, and the lncRNA XIST/miR-381-3P/STAT1 axis may be a potential therapeutic target for LN.