bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women’s leadership matters in education for planetary health
Authors: Abbonizio Jessica , Ho Susie Siew Yuen , Reid Alan , Simmons Margaret 
Published: July 2024

AbstractWomen in higher education are in critical positions for preparing future healthcare professionals to support the health of people and the planet. However, women’s leadership remains an under-explored area in education for planetary health (EPH) literature. This article articulates, through a review of empirical and theoretical literature, that it is vital to highlight women’s perspectives as leaders of EPH. We argue that women are well positioned for developing and delivering EPH, and that exploring women’s leadership in EPH will nuance understandings of the gendered challenges that leaders in this field face. We propose that women’s leadership in EPH can be enhanced through celebrating role models as well as improving access to partnership, funding, and research opportunities. This article adds women to the agenda of the diverse voices that need to be heard for advancing EPH, inspiring others to join the growing collective of educators partnering for the health of people and the planet.
Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans
Authors: Lyu Haimeng , Chamberlin Helen M. 
Published: July 2024

ABSTRACT
Ras genes are important oncogenes that are frequently mutated in cancer. Human oncogenic variants exhibit functional distinctions in terms of their representation in different cancer types, impact on cellular targets and sensitivity to pharmacological treatments. However, how these distinct variants influence and respond to the cellular networks in which they are embedded is poorly understood. To identify novel participants in the complex interplay between Ras genotype and cell interaction networks in vivo, we have developed and tested an experimental framework using a simple vulva-development assay in the nematode C. elegans. Using this system, we evaluated a set of Ras oncogenic substitution changes at G12, G13 and Q61. We found that these variants fall into distinct groups based on phenotypic differences, sensitivity to gene dosage and inhibition of the downstream kinase MEK and their response to genetic modulators that influence Ras activity in a non-autonomous manner. Together, our results demonstrated that oncogenic C. elegans Ras variants exhibit clear distinctions in how they interface with the vulva-development network and showed that extracellular modulators yield variant-restricted effects in vivo.
Talent Poaching and Job Rotation
Authors: Battiston Diego , Espinosa Miguel , Liu Shuo 
Published: July 2024

The value of a firm’s service lies both in its workers and its relationship with clients. In this paper, we study the interaction between the client-specific experience accumulated by workers, poaching behaviour from clients, and strategic rotation of workers by firms. Using detailed personnel data from a security service firm, we show that an increase in client-specific experience increases both the productivity of workers and their probability of being poached. The firm reacts to this risk by rotating workers across multiple clients, and more frequently so for those workers more likely to be poached. Furthermore, we find that after a policy change that prohibited poaching, the firm sharply decreased the frequency of rotation, which in turn increased workers’ productivity. We propose a theoretical model that guides the empirical patterns and allows us to argue their external validity beyond our specific empirical setting. Finally, we provide survey evidence from the security service sector, demonstrating the consistency between our findings and industry observations. This paper was accepted by Lamar Pierce, organizations. Funding: S. Liu acknowledges financial support from the National Natural Science of China [Grants 72192844 and 72322006]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.02275 .
Polymyalgia rheumatica during the course of limited cutaneous scleroderma: an unusual and challenging coexistence
Authors: Lorenzo-Villalba Noel , Habib Charlene , Docquier Léa , Nasco Edward , Imperiale Alessio , Andrès Emmanuel , Terrade Jean Edouard 
Published: July 2024

A 50-year-old patient with a history of limited cutaneous scleroderma began with polyarthralgia (left shoulder, elbows and hips) without stiffness or associated inflammatory syndrome. Treatment with oral anti-inflammatory drugs was started on suspicion of peripheral spondyloarthritis with partial response. This progressed with the appearance of stiffness and functional limitation of the hips as well as an increase in the inflammatory syndrome two weeks after onset. It was decided to perform an 18F-FDG-PET scan compatible with polymyalgia rheumatica. The patient was treated with oral corticosteroids with an excellent response after one week of treatment.
Direct factor Xa inhibitors and the risk of cancer and cancer mortality: A Danish population-based cohort study
Authors: Bosch Floris , Horváth-Puhó Erzsébet , Cannegieter Suzanne C. , van Es Nick , Sørensen Henrik T. 
Published: July 2024

Background
Preclinical animal studies have suggested that myeloid cell–synthesized coagulation factor X dampens antitumor immunity and that rivaroxaban, a direct factor Xa inhibitor, can be used to promote tumor immunity. This study was aimed at assessing whether patients with atrial fibrillation taking direct factor Xa inhibitors have lower risk of cancer and cancer-related mortality than patients taking the direct thrombin inhibitor dabigatran.

Methods and findings
This nationwide population-based cohort study in Denmark included adult patients with atrial fibrillation and without a history of cancer, who started taking a factor Xa inhibitor or dabigatran between 2011 and 2015. Data on medical history, outcomes, and drug use were acquired through Danish healthcare registries. The primary outcome was any cancer. Secondary outcomes were cancer-related mortality and all-cause mortality. Outcome events were assessed during 5 years of follow-up in an intention-to-treat analysis. The propensity score-based inverse probability of treatment weighting was used to compute cumulative incidence and subdistribution hazard ratios (SHRs) and corresponding 95% confidence intervals (CIs), with death as a competing event. Propensity scores were estimated using logistic regression and including in the model sex, age group at index date, comorbidities, and use of comedications. A total of 11,742 patients with atrial fibrillation starting a factor Xa inhibitor and 11,970 patients starting dabigatran were included. Mean age was 75.2 years (standard deviation [SD] 11.2) in the factor Xa cohort and 71.7 years (SD 11.1) in the dabigatran cohort. On the basis of the propensity score-weighted models, after 5 years of follow-up, no substantial difference in the cumulative incidence of cancer was observed between the factor Xa inhibitor (2,157/23,711; 9.11%, 95% CI [8.61%,9.63%]) and dabigatran (2,294/23,715; 9.68%, 95% CI [9.14%,10.25%]) groups (SHR 0.94, 95% CI [0.89,1.00], P value 0.0357). We observed no difference in cancer-related mortality (factor Xa inhibitors cohort 1,028/23,711; 4.33%, 95% CI [4.02%,4.68%]. Dabigatran cohort 1,001/23,715; 4.22%, 95% CI [3.83%,4.66%]; SHR 1.03, 95% CI [0.94,1.12]), but all-cause mortality was higher in the factor Xa inhibitor cohort (factor Xa inhibitors cohort 7,416/23,711; 31.31%, 95% CI [30.37%,32.29%]. Dabigatran cohort 6,531/23,715; 27.56%, 95% CI [26.69%,28.45%]; HR 1.17, 95% CI [1.13,1.21]). The main limitations of the study were the possibility of residual confounding and the short follow-up period.

Conclusions
In this population based cohort study, factor Xa inhibitor use was not associated with an overall lower incidence of cancer or cancer-related mortality when compared to dabigatran. We did observe an increase in all-cause mortality in the factor Xa inhibitor cohort.
Efficacy of acupuncture combined with traditional Chinese herbal for primary epilepsy patients with cognitive impairment: A protocol for systematic review and meta-analysis
Authors: Xue Hua , Zeng Li , He Hongxian , Xu Dongxun 
Published: July 2024

Background
Epilepsy is a common and serious chronic neurological disorder, and some patients suffer from cognitive dysfunction. We aim to assess the efficacy and safety of acupuncture combined with traditional Chinese herbal for primary epilepsy patients with cognitive impairment.

Methods
To search the randomized control trials (RCTs) published before April 20, 2023 from PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Web of science, and Wanfang Database. The risk of bias within each individual trial was evaluated using the Cochrane Collaboration tool. RevMan5.3 software was used for statistical analysis. The odds ratio (OR) or weighted mean difference (WMD) with a 95% confidence interval (CI) was calculated for each RCT before data pooling.

Results
The primary outcomes involve changes in cognitive function and behavioral disturbances. The secondary outcomes focused on quality of life and adverse effects.

Conclusion
The results of this review are expected to provide new guidelines for the treatment of primary epilepsy patients with cognitive impairment.

Trial registration
This systematic review protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO) (Registration number: CRD42023415355).
Characteristics and outcomes of community-based perinatal peer support: Protocol for a systematic review
Authors: Branjerdporn Grace , Kimball Hayley , Pirotta Reaksmey , Branjerdporn Nataya , Collins Taryn , Bowman Genevieve , Gillespie Kerri M. 
Published: July 2024

Background
Mental health issues and parenting difficulties in the perinatal period are common, and have significant negative impacts on individuals, families, and broader society. Community-based peer support programs might be an effective adjunct to standard mental health interventions in perinatal mental health issues, specifically where low-cost interventions are required, or access to professional care is limited.

Methods
A systematic review will be undertaken. Searches will be conducted on four electronic databases (Pubmed, Embase, Cinahl, and PsycINFO), using terms related to perinatal mental health and peer support. Literature will be screened by title and abstract and then by full text. Selected studies will be evaluated using the Quality Assessment with Diverse Studies (QuADS) tool. Data relevant to community-based perinatal peer support intervention characteristics and outcomes will be extracted, and synthesised narratively.

Discussion
This review will contribute to the existing evidence about perinatal mental health peer support, by synthesising information about community-based interventions specifically. The findings will be used to inform the design, implementation, and evaluation of a community-based perinatal mental health peer support program in urban and rural/remote hospital and health services in Australia.

Trial registration
Systematic review registration: CRD42023451568.
Providers’ experiences with abortion care: A scoping review
Authors: Dempsey B. , Callaghan S. , Higgins M. F. 
Published: July 2024

Background
Induced abortion is one of the most common gynecological procedures in the world, with as many as three in every ten pregnancies ending in abortion. It, however, remains controversial. The objective of this scoping review was to explore and map existing literature on the experiences of those who provide abortion care.

Methods and findings
This exploratory review followed the Levac et al. guidelines and was reported in accordance with the PRISMA-ScR checklist. CINAHL, Cochrane, EMBASE, PsycInfo, PubMed, and Web of Science were used to identify peer-reviewed, original research articles published on providers’ experience of abortion. We identified 106 relevant studies, which include a total sample of 4,250 providers from 28 countries and six continents. Most of the studies were qualitative (n = 83), though quantitative (n = 15) and mixed methods (n = 8) studies were also included. We identified two overarching themes: (1) Providers’ experiences with abortion stigma and (2) Providers’ reflections on their abortion work. Our findings suggest that providers from around the world experience challenges within society and their communities and workplaces which reinforce the stigmatization and marginalization of abortion and pose questions about the morality of this work. Most, however, are proud of their work, believe abortion care to be socially important and necessary, and remain committed to the provision of care.

Conclusions
The findings of this review provide a comprehensive overview on the known experiences of providing abortion care. It is a key point of reference for international providers, researchers, and advocates to further this area of research or discussion in their own territories. The findings of this review will inform future work on how to support providers against stigmatization and will offer providers the chance to reflect on their own experiences.
Association of urinary bisphenol A with hyperlipidemia and all-cause mortality: NHANES 2003–2016
Authors: Guo Lijuan , Zhao Pin , Xue Shilong , Zhu Zhaowei 
Published: July 2024

Background
The connection between urinary bisphenol A (BPA) and hyperlipidemia is still unclear, and few studies have evaluated whether urinary BPA affects mortality among individuals with hyperlipidemia. Therefore, we aimed to investigate the link between urinary BPA and hyperlipidemia and assess the impact of urinary BPA on mortality risk in subjects with hyperlipidemia.

Methods
We analyzed data of the National Health and Nutrition Examination Survey from 2003 to 2016. Multivariable logistic analysis was performed to examine the relationship between urinary BPA and hyperlipidemia. Cox regression analysis was carried out to investigate the relationship between urinary BPA and all-cause mortality in subjects with hyperlipidemia.

Results
This study included 8,983 participants, of whom 6,317 (70.3%) were diagnosed with hyperlipidemia. The results showed that urinary BPA was higher in participants with hyperlipidemia group than those without hyperlipidemia (3.87 ± 0.32 vs. 2.98 ± 0.14, P = 0.01). Urinary BPA levels were analyzed in tertiles. Compared with tertile 1 of BPA (reference), the odds ratio (95% confidence interval) of hyperlipidemia related to tertile 3 of BPA was 1.28 (1.11–1.48). The hazard ratio for all-cause death associated with the highest versus lowest tertile of urinary BPA was 1.20 (95% confidence interval: 1.01–1.44; P = 0.04) among participants with hyperlipidemia.

Conclusions
The study indicated a positive relationship between urinary BPA and the risk of hyperlipidemia. Urinary BPA was associated with a significantly higher risk of all-cause mortality in adults with hyperlipidemia.
Validation of the patient reported experiences and outcomes of safety in primary care compact Form Brazil
Authors: Silva Ana Elisa Bauer de Camargo , Sousa Tanielly Paula , Guimaraes Rafael Alves , Pagotto Valéria , Lima Juliana Carvalho de , Sousa Maiana Regina Gomes de , Bernardes Cristina Alves 
Published: July 2024

Objective
To analyze the psychometric properties of the cross-culturally adapted version of the Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS–PC) Compact Form Brazil.

Methods
A methodological study was conducted with 281 adult Primary Health Care users. Data collection took place online. Confirmatory Factor Analysis (CFA) was used to evaluate the psychometric properties of the PREOS–PC after the process of cross-cultural adaptation to the Brazilian context. Internal consistency was evaluated through Cronbach’s alpha coefficient (α) and McDonald’s omega coefficient (ω).

Results
The sample consisted of 73.3% women. The mean age was 36.1 years (SD = 12.2). Of the 23 items of the PREOS–PC that were eligible for CFA, a model with four correlated domains and 16 items presented satisfactory fit indexes. The domains were Practice Activation (PrA) (four items), Patient Activation (PaA) (two items), Experiences of patient safety events (EPaS) (five items) and Outcomes of patient safety (OPaS) (six items). One domain (GPeS) presented one question with a 0 to 10 response scale and two open questions, which cannot be inserted in the CPA due to the nature of the items, but can be included in the application of the scale, being evaluated individually. In this factorial model, five items (EPaS2, EPaS3, EPaS4, EPaS5, EPaS6 and EPaS8) presented factor loadings ≤ 0.30. The α and ω values demonstrated good internal consistency for all domains of the PREOS–PC.

Conclusions
The Brazilian version of the PREOS–PC Compact Form Brazil composed of four domains (PrA, PA, EPaS and OPaS) and 16 items presented evidence of validation of its psychometric properties and can be used to evaluate the experiences and results of patient safety in Primary Health Care in the Brazilian context.
Education in focus: Significant improvements in student learning and satisfaction with ophthalmology teaching delivered using a blended learning approach
Authors: Doyle Andrea J. , Murphy Conor C. , Boland Fiona , Pawlikowska Teresa , Ní Gabhann-Dromgoole Joan 
Published: July 2024

Purpose
This study aimed to measure student satisfaction with a revised ophthalmology delivery format, which due to the pandemic had previously relied on a remote online flipped classroom (OFC) format compared to a blended learning format. This educational strategy combined online learning with in-person seminars and practical patient centred sessions. Our previous investigations demonstrated a significant lack of student satisfaction with a curriculum solely reliant on a remote OFC, as such we hypothesised that a blended learning approach would result in improved levels of student satisfaction and knowledge gain.

Methods
Non-randomised intervention study of two groups; group 1 = OFC group and group 2 = BL group, compared perspectives of 4th year ophthalmology students using a validated course evaluation questionnaire (CEQ).

Results
A total of 59 students from the BL group (n = 257; response rate = 23.0%) and 28 from the OFC group agreed to participate in the study (n = 114; response rate = 24.6%). Participants in the BL group felt it was easier to determine the standard of work that was expected (77.42% v 60.71%) and demonstrated significantly increased satisfaction with staff motivation of students (95.16% v 64.29%, p <0.001) and provision of feedback (74.19% v 46.43%, p = 0.004), compared to the OFC group. Furthermore, students in the BL group also felt the course significantly improved their analytical skills (64.52% v 42.85%, p = 0.023) and ability to work as part of team (69.36% v 25%, p <0.001) as well as reporting reduced dissatisfaction with the level of choice afforded in terms of how they would learn (33.88% v 60.71%, p = 0.31) and the how they were assessed (59.68% v 89.28%, p = 0.004). No evidence of a statistical difference in exam score was observed.

Conclusions
The COVID-19 pandemic necessitated an unavoidable pivot to online and distance learning, to meet the challenges presented by government mandates and social distancing requirements. Since many of these directives have been reversed, it is important to evaluate the effectiveness and learner perceptions’ of the online and distance learning interventions. In this study we demonstrated a significant student preference for BL compared to the OFC approach, with comparable student performances determined by MCQ examinations. Our findings suggest a preference for reintroducing in-person and patient engagement activities in post-pandemic health professions education.
THE BIRDS OF THE KANGEAN ISLANDS AND AN APPRAISAL OF THEIR CONSERVATION STATUS
Authors: Berryman Alex J. , Rutt Cameron L. , Irham Mohammad , Van Balen Sebastianus 
Published: July 2024

The Kangean islands are a biologically poorly known archipelago situated in the Java Sea, Indonesia, approximately 120 km directly north of Bali. These islands host an avifauna comprising at least 13 endemic subspecies, two of which have by some sources recently been considered species. We combine historical published literature with our own surveys of the archipelago in 2007–2008, 2010 and 2023 to produce a complete list of the islands’ birds (n=140 species) and their distribution across the islands. We evaluate in more detail the conservation status of all endemic taxa, as well as several others we consider to be of concern. Despite its listing as Vulnerable on the IUCN Red List, the endemic Kangean Tit-babbler Mixornis prillwitzi is highly tolerant of habitat degradation and is among the islands’ least threatened birds. However, because of trapping, the archipelago’s endemic taxon of Red-breasted Parakeet Psittacula alexandri kangeanensis, and its populations of Green Junglefowl Gallus varius and Common Hill Myna Gracula religiosa are likely at risk of extirpation. The endemic taxon of White-rumped Shama Copsychus malabaricus, sometimes afforded species rank as ‘Kangean Shama’ C. nigricauda, may already be (at least functionally) extinct in the main archipelago. We recommend longer and more detailed surveys of the islands’ birds, and that an effective protected area is established on main Kangean island, which hosts the largest area of remaining forest in the archipelago and most of its endemic taxa.
Kejadian Respiratory Distress Syndrome pada Bayi Lahir Prematur di Rumah Sakit Hasan Sadikin Bandung
Authors: Kadi Fiva Aprilia , Paramita Ajeng Anggia , Rakhmilla Lulu Eva 
Published: July 2024

Latar belakang. Respiratory Distress Syndrome adalah masalah serius yang menyebabkan morbiditas dan mortalitas tinggi pada bayi prematur. Beberapa faktor risiko, antara lain, jenis kelamin laki-laki, ibu dengan diabetes melitus, ketuban pecah dini, hipertensi, usia ibu <20 tahun, persalinan sesar, berat lahir <2500 gram, dan paritas.Tujuan. Penelitian ini bertujuan untuk mengidentifikasi kejadian Respiratory Distress Syndrome pada bayi prematur.Metode. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional. Subjek dipilih secara consecutive sampling dari data rekam medis. Kriteria inklusi adalah bayi berusia kurang dari 37 minggu dan kriteria eksklusi bayi kembar, bayi dengan sepsis, serta data rekam medis yang tidak lengkap. Dari 872 data didapatkan sampel 361 bayi yang memenuhi kriteria. Analisis data menggunakan uji univariat, bivariat (Chi-square), dan multivariat (regresi logistik).Hasil. Analisis bivariat menunjukkan bahwa usia ibu ?20 tahun, usia kehamilan <28 minggu, berat lahir <2500 gram, dan jenis kelamin laki-laki memiliki hubungan signifikan. Analisis multivariat menunjukkan dua faktor risiko signifikan: (1) Usia ibu <20 tahun memiliki pengaruh lebih besar dalam pencegahan dibandingkan dengan usia ibu ?20 tahun (p=0,000; OR IK95%: 0,089-0,402), dan (2) Berat lahir bayi <2500 gram meningkatkan risiko lebih dari tiga kali lipat untuk mengalami Respiratory Distress Syndrome dibandingkan dengan berat lahir ?2500 gram (p=0,024; OR IK95%: 1,162-8,872).Kesimpulan. Faktor risiko kejadian Respiratory Distress Syndrome pada bayi prematur sangat erat kaitannya dengan kondisi ibu dan bayi, seperti usia ibu, berat lahir, usia kehamilan, dan jenis kelamin. Dalam penelitian ini tidak ditunjukkan hubungan signifikan akibat faktor lain, seperti Diabetes Melitus, hipertensi, PROM, paritas, dan jenis persalinan.