bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cochlear implantation: Minimal hair removal technique
Authors: Roberson Joseph B. , Stidham Katrina R. , Scott Kenneth M. , Tonokawa Lisa 
Published: May 2013

This prospective study was undertaken to evaluate the safety and patient acceptance of minimal hair removal during cochlear implantation. Forty‐six consecutive patients (17 adults, 29 children; age range 13 months to 84 years) received cochlear implantation with a minimal hair removal technique. A questionnaire was used to evaluate acceptance and value of this technique among the first 15 patients and parents. Postoperative examinations were completed 1 and 4 weeks after implantation. Patients were monitored for complications, which included 3 cases of transient seroma, 2 cases of transient dysequilibrium, 2 individual electrode failures, and 1 facial nerve stimulation. Importantly, no wound infections were documented. Use of a small shave technique did not increase surgical risk. This technique has proved to be cosmetically and psychologically more desirable for the patients and their families than complete hair removal in the operative field.
Long‐term results with hydroxylapatite middle ear implants
Authors: Goldenberg Robert A. , Driver Mark 
Published: May 2013

PURPOSEThis study evaluated long‐term results in patients who had ossicular reconstruction with a Goldenberg hydroxylapatite implant.METHODSA total of 233 patients underwent implantation; of these, 77 had 5‐year or longer follow‐up and are the subjects of this study of long‐term hearing results. All 233 patients were included for analysis of extrusion rate and postoperative otorrhea.RESULTSThe hearing success rate at long‐term follow‐up was 56.8%; the mean air‐bone gap was 21.1 dB. Prosthesis extrusion occurred in 5.29% of the 233 patients, and visible slippage occurred in 7.7%. Overall, 50.6% of patients met the criteria for successful hearing, which included no extrusion and a dry ear. Better hearing before surgery and presence of the malleus long process were factors associated with a successful hearing result, as was tympanoplasty alone and canal wall up tympanomastoidectomy.CONCLUSIONHydroxylapatite hybrid prostheses provide stable hearing results over time with low extrusion and a dry ear overall.
Unrecognized benign paroxysmal positional vertigo in elderly patients
Authors: Oghalai John S. , Manolidis Spiros , Barth Justine L. , Stewart Michael G. , Jenkins Herman A. 
Published: May 2013

Balance disorders in elderly patients are associated with an increased risk of falls but are often difficult to diagnose because of comorbid chronic medical problems. We performed a cross‐sectional study to determine the prevalence of unrecognized benign paroxysmal positional vertigo (BPPV) and associated lifestyle sequelae in a public, inner‐city geriatric population. Dizziness was found in 61% of patients, whereas balance disorders were found in 77% of patients. Nine percent were found to have unrecognized BPPV. Multivariate analysis demonstrated that the presence of a spinning sensation and the absence of a lightheadedness sensation predicted the presence of unrecognized BPPV. Patients with unrecognized BPPV were more likely to have reduced activities of daily living scores, to have sustained a fall in the previous 3 months, and to have depression. These data indicate that unrecognized BPPV is common within the elderly population and has associated morbidity. Further prospective studies are warranted.
Dynamics of nasopharyngitis in children
Authors: Brook Itzhak , Gober Alan E. 
Published: May 2013

PURPOSEOur goal was to characterize the dynamics and bacterial interaction of the aerobic and anaerobic flora of nasal discharge of children at different stages of uncomplicated nasopharyngitis.METHODS AND PATIENTSSerial semiquantitative nasopharyngeal (NP) and quantitative nasal discharge (ND) cultures were taken every 3 to 5 days from 20 children in whom purulent discharge eventually developed (group 1), and a single culture was obtained from a group of 20 who had only clear discharge (group 2).RESULTSAerobic and anaerobic bacteria were isolated from all NP cultures. Bacterial growth was present in 8 (40%) NDs of group 2. Only 7 (35%) of the clear NDs of group 1 showed bacterial growth; the number increased to 14 (70%) at the mucoid stage and 20 (100%) at the purulent stage. It declined to 6 (30%) at the final clear stage. The number of species and total number of organisms increased in the NDs of group 1. Group 1 patients had higher recovery rates of Streptococcus pneumoniae and Haemophilus influenzae in their NP cultures than group 2 patients (P < 0.05). During the purulent stage, Peptostreptococcus species were isolated in 15 (75%), Fusobacterium species in 10 (50%), Prevotella species in 9 (45%), H influenzae in 8 (40%), S pneumoniae in 6 (30%), and β‐hemolytic streptococci in 5 (25%) of group 1 NDs. This was higher than their recovery in the clear stages of both groups and the mucoid stage of group 1. A total of 8 organisms capable of interfering with the growth of potential pathogens were isolated from the NPs of group 1, as compared with 35 from group 2 (P < 0.001).CONCLUSIONSThe development of purulent nasopharyngitis is associated with the pre‐existing presence of potential pathogens and the absence of interfering organisms.
Prevalence of unsuspected acoustic neuroma found by magnetic resonance imaging
Authors: Anderson Timothy D. , Loevner Laurie A. , Bigelow Douglas C. , Mirza Natasha 
Published: May 2013

OBJECTIVESAcoustic neuromas (ANs) comprise 6% of intracranial tumors. Population and autopsy studies have widely divergent estimates of AN incidence. With widespread use of MRI, asymptomatic ANs will be identified, which should improve estimates of the prevalence of this tumor.METHODSThe reports of all brain MRI scans during a 5‐year period were retrospectively searched for the diagnosis of AN. MRIs obtained because of a suspicion of AN were discarded, leaving only the unsuspected ANs.RESULTSA total of 24,246 MRI studies were performed during this time period. Seventeen patients had unsuspected ANs. Eight tumors were smaller than 1 cm, 6 were between 1 and 2 cm, and 3 were 2 cm or larger. For all MRI scans, we found 7.0 unsuspected ANs per 10,000 brain MRI studies (0.07%).CONCLUSIONThe true prevalence of AN is likely greater than the 10 per million per year previously reported. This implies that there may be a larger number of asymptomatic ANs than previously suspected.
Botulinum toxin injection of the cricopharyngeus muscle for the treatment of dysphagia
Authors: Ahsan Syed F. , Meleca Robert J. , Dworkin James Paul 
Published: May 2013

OBJECTIVEThis study was conducted to evaluate, subjectively and objectively, the diagnostic and therapeutic effects of botulinum toxin (Botox) in patients with dysphagia caused by cricopharyngeus (CP) muscle spasm and/or hypertonicity.METHODSA retrospective chart review was done of 5 patients with normally functioning larynges treated with CP Botox injection for dysphagia caused by perceived spasm. Subjective measures of swallowing function after injection were obtained with a patient questionnaire. Objective data were obtained both before and after surgery by one or more of the following tests: modified barium swallow study, manometry, videostroboscopy, and fiberoptic endoscopic evaluation of swallowing. Quality‐of‐life measures were obtained with a swallowing rating scale.RESULTSOverall, all patients had initial improvement in swallowing after Botox injection. The duration of benefit was from 2 to 14 months. There were no complications. Four of 5 patients had long‐term benefits, as evidenced by decreased or eliminated aspiration symptoms, removal of tracheotomy, ability to eat solid foods, and weight gain. One patient continues to have poor swallowing function.CONCLUSIONBotox injection of the CP muscle to treat dysphagia is effective in patients with underlying muscle spasm or hypertonicity. A positive response to Botox can also help confirm the diagnosis of CP muscle spasm.
Malignant peripheral nerve sheath tumors of the head and neck: Analysis of prognostic factors
Authors: Loree Thom R. , North James H. , Werness Bruce A. , Nangia Rina , Mullins Alan P. , Hicks Wesley L. 
Published: May 2013

Malignant peripheral nerve sheath tumors of the head and neck region are uncommon and may be associated with neurofibromatosis or occur in a sporadic manner. This is a retrospective review of 17 patients with these tumors who were treated at a single institution. Analysis of clinical and pathologic factors that influenced outcome was performed. There were 9 men and 8 women. Seven patients had a history of neurofibromatosis. Radiotherapy was implicated as a possible etiologic factor in 4 patients. The neck was the most frequently involved site. Overall survival at 5 years was 52%. Survival was improved for women and for patients with lowgrade tumors. Age, tumor site, and size had no impact on survival. Survival was worse for patients with neurofibromatosis than for those with the sporadic form of the disease (P= 0.02). Survival was calculated by the method of Kaplan and Meier. The significance of such results was based on results of the log rank test. Local recurrence correlated with tumor size and resection margin status. No local recurrences occurred in those patients who had negative margins of resection and received adjuvant radiotherapy. Tumor grade was predictive of the development of distant metastases. Negative margins of resection are essential for obtaining local control, and the addition of adjuvant radiotherapy may be beneficial in this group. Salvage surgery for local recurrence is possible in some patients.
Ballet dancers cardiorespiratory, oxidative and muscle damage responses to classes and rehearsals
Authors: Rodrigues‐Krause Josianne , Krause Mauricio , Cunha Giovani dos Santos , Perin Diana , Martins Jocelito B. , Alberton Cristine Lima , Schaun Maximiliano I. , De Bittencourt Paulo Ivo Homem , Reischak‐Oliveira Alvaro 
Published: May 2013

AbstractThis study aimed to describe and compare ballet dancers' cardiorespiratory responses, muscle damage and oxidative stress levels during a ballet class (practice of isolated ballet exercises performed with barre/hand‐rail support and across‐the‐floor movements to improve technical skills) and rehearsal (practice of ballet choreography involving technical‐artistic skills to improve dancers' performance for shows). The 12 advanced female ballet dancers undertook three exercise sessions: maximum effort test, class and rehearsal. Heart rate (HR) and oxygen consumption (V̇O2) were continuously measured. Lactate was determined before 15 min and after class and rehearsal. Blood was sampled pre, post and 48 h after class and rehearsal for creatine kinase (CK), lipid peroxides (LPO) and glutathione analysis (GSSG/GSH). Class was of lower intensity than rehearsal as shown by V̇O2, HR and lactate values: V̇O2 (mL.kg−1.min−1): 14.5±2.1 vs 19.1±1.7 (p < 0.001); HR (bpm.min−1): 145.7±17.9 vs 174.5±13.8 (p < 0.001); lactate (mmol.L−1): 4.2±1.1 vs 5.5±2.7 (p = 0.049). CK (IU) increased following class and rehearsal, remaining high 48 h after: class (pre = 109.3±48.5; post = 144±60; 48 h = 117.2±64.6); rehearsal (pre = 78.6±52.1; post = 122±70.7; 48 h = 104.9±89.5). LPO (µM) increased from pre‐class (1.27±0.19) to post‐class (1.41±0.19) and went down after 48 h (1.20±0.22). No LPO time‐course changes followed the rehearsal. GSSG/GSH decreased 48 h after class and rehearsal. Greater increases in LPO post‐class suggest it promotes CK release by an oxidative membrane‐damage mechanism. Physiological increases of LPO and CK in class indicate it prepares the dancers for exercise‐induced oxidative stress and muscle damage during rehearsals. Ballet dancers' muscle damage and oxidative stress responses seem not to be dependent on exercise intensity based on V̇O2 responses.
Repeated supra‐maximal sprint cycling with and without sodium bicarbonate supplementation induces endothelial microparticle release
Authors: Kirk Richard J. , Peart Daniel J. , Madden Leigh A. , Vince Rebecca V. 
Published: May 2013

AbstractUnder normal homeostatic conditions, the endothelium releases microparticles (MPs), which are known to increase under stressful conditions and in disease states. CD105 (endoglin) and CD106 (vascular cell adhesion molecule‐1) are expressed on the surface of endothelial cells and increased expression in response to stress may be observed. A randomised‐controlled double‐blinded study aimed to examine the use of endothelial MPs as a marker for the state of one's endothelium, as well as whether maintaining acid–base homeostasis affects the release of these MPs. This study tested seven healthy male volunteers, who completed a strenuous cycling protocol, with venous blood analysed for CD105+ and CD106+ MPs by flow cytometry at regular intervals. Prior to each trial participants consumed either 0.3 g·kg−1 body mass of sodium bicarbonate (NaHCO3), or 0.045 g·kg−1 body mass of sodium chloride (NaCl). A significant rise in endothelial CD105+ MPs and CD106+ MPs (p<0.05) was observed at 90 min post‐exercise. A significant trend was shown for these MPs to return to resting levels 180 min post‐exercise in both groups. No significance was found between experimental groups, suggesting that maintaining acid–base variables closer to basal levels has little effect upon the endothelial stress response for this particular exercise mode. In conclusion, strenuous exercise is accompanied by MP release and the endothelium is able to rapidly recover in healthy individuals, whilst maintaining acid–base homeostasis does not attenuate the MP release from the endothelium after exercise.
MEME-LaB: motif analysis in clusters
Authors: Brown Paul , Baxter Laura , Hickman Richard , Beynon Jim , Moore Jonathan D. , Ott Sascha 
Published: May 2013

Abstract
Summary: Genome-wide expression analysis can result in large numbers of clusters of co-expressed genes. Although there are tools for ab initio discovery of transcription factor-binding sites, most do not provide a quick and easy way to study large numbers of clusters. To address this, we introduce a web tool called MEME-LaB. The tool wraps MEME (an ab initio motif finder), providing an interface for users to input multiple gene clusters, retrieve promoter sequences, run motif finding and then easily browse and condense the results, facilitating better interpretation of the results from large-scale datasets.
Availability: MEME-LaB is freely accessible at: http://wsbc.warwick.ac.uk/wsbcToolsWebpage/.
Contact: p.e.brown@warwick.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
ACCUSA2: multi-purpose SNV calling enhanced by probabilistic integration of quality scores
Authors: Piechotta Michael , Dieterich Christoph 
Published: May 2013

Abstract
Summary: Direct comparisons of assembled short-read stacks are one way to identify single-nucleotide variants. Single-nucleotide variant detection is especially challenging across samples with different read depths (e.g. RNA-Seq) and high-background levels (e.g. selection experiments). We present ACCUSA2 to identify variant positions where nucleotide frequency spectra differ between two samples. To this end, ACCUSA2 integrates quality scores for base calling and read mapping into a common framework. Our benchmarks demonstrate that ACCUSA2 is superior to a state-of-the-art SNV caller in situations of diverging read depths and reliably detects subtle differences among sample nucleotide frequency spectra. Additionally, we show that ACCUSA2 is fast and robust against base quality score deviations.
Availability: ACCUSA2 is available free of charge to academic users and may be obtained from https://bbc.mdc-berlin.de/software.
Contact: christoph.dieterich@mdc-berlin.de
Supplementary information: Supplementary data are available at Bioinformatics online.
TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization
Authors: Ollion Jean , Cochennec Julien , Loll François , Escudé Christophe , Boudier Thomas 
Published: May 2013

Abstract
Motivation: The cell nucleus is a highly organized cellular organelle that contains the genetic material. The study of nuclear architecture has become an important field of cellular biology. Extracting quantitative data from 3D fluorescence imaging helps understand the functions of different nuclear compartments. However, such approaches are limited by the requirement for processing and analyzing large sets of images.
Results: Here, we describe Tools for Analysis of Nuclear Genome Organization (TANGO), an image analysis tool dedicated to the study of nuclear architecture. TANGO is a coherent framework allowing biologists to perform the complete analysis process of 3D fluorescence images by combining two environments: ImageJ (http://imagej.nih.gov/ij/) for image processing and quantitative analysis and R (http://cran.r-project.org) for statistical processing of measurement results. It includes an intuitive user interface providing the means to precisely build a segmentation procedure and set-up analyses, without possessing programming skills. TANGO is a versatile tool able to process large sets of images, allowing quantitative study of nuclear organization.
Availability: TANGO is composed of two programs: (i) an ImageJ plug-in and (ii) a package (rtango) for R. They are both free and open source, available (http://biophysique.mnhn.fr/tango) for Linux, Microsoft Windows and Macintosh OSX. Distribution is under the GPL v.2 licence.
Contact: thomas.boudier@snv.jussieu.fr
Supplementary information: Supplementary data are available at Bioinformatics online.
DrugMap Central: an on-line query and visualization tool to facilitate drug repositioning studies
Authors: Fu Changhe , Jin Guangxu , Gao Junfeng , Zhu Rui , Ballesteros-villagrana Efren , Wong Stephen T. C. 
Published: May 2013

Abstract
Summary: Systematic studies of drug repositioning require the integration of multi-level drug data, including basic chemical information (such as SMILES), drug targets, target-related signaling pathways, clinical trial information and Food and Drug Administration (FDA)-approval information, to predict new potential indications of existing drugs. Currently available databases, however, lack query support for multi-level drug information and thus are not designed to support drug repositioning studies. DrugMap Central (DMC), an online tool, is developed to help fill the gap. DMC enables the users to integrate, query, visualize, interrogate, and download multi-level data of known drugs or compounds quickly for drug repositioning studies all within one system.
Availability: DMC is accessible at http://r2d2drug.org/DMC.aspx.
Contact: STWong@tmhs.org
Pitfalls and guidelines for “recycling” models for ecosystem-based fisheries management: evaluating model suitability for forage fish fisheries
Authors: Essington Timothy E. , Plagányi Éva E. 
Published: May 2013

Abstract
Essington, T. E., and Plagányi, É. E. Pitfalls and guidelines for “recycling” models for ecosystem-based fisheries management. – ICES Journal of Marine Science, 71: . Ecosystem models have been developed for many marine systems to provide guidance on fisheries management strategies that protect key ecological functions. These models are commonly “recycled”, i.e. applied to new questions or policy concerns after the initial phase of model development, testing, and application. Because decisions about the model structure are typically based on the intended model use, it is important to recognize limits in the capacity of models to address questions for which they were not specifically designed. Here, we evaluate existing foodweb models in the context of their ability to identify key forage species in foodwebs and to test management strategies for fisheries that target them. We find that the depth and breadth with which predator species are represented are commonly insufficient for evaluating sensitivities of predator populations to forage fish depletion. We demonstrate that aggregating predator species into functional groups creates bias in foodweb metrics such as connectance. Models also varied considerably with respect to the extent that they have been tuned or fitted to retrospective patterns and the degree to which key sensitivities are identified. We use this case study to provide several general recommendations when “recycling” ecosystem and foodweb models. Briefly, we suggest as routine procedure careful scrutiny of structural model attributes, of scales at which ecological processes are included, and quality of fits for key functional groups.
A correction to “Distribution and biological characteristics of Atlantic salmon (Salmo salar) at Greenland based on the analysis of historical tag recoveries”
Authors: Reddin David G. , Hansen Lars Petter , Bakkestuen Vegar , Russell Ian , White Jonathan , Potter E. C. E. (Ted) , Dempson J. Brian , Sheehan Timothy F. , Maoiléidigh Niall Ó , Smith Gordon W. , Isaksson Arni , Jacobsen Jan Arge , Fowler Mark , Mork Kjell Arne , Amiro Peter 
Published: May 2013

Abstract
Reddin, D. G., Hansen, L. P., Bakkestuen, V., Russell, I., White, J., Potter, E. C. E., Dempson, J. B., Sheehan, T. F., Ó Maoiléidigh, N., Smith, G. W., Isaksson, A., Jacobsen, J. A., Fowler, M., Mork, K. A., and Amiro, P. 2013. Distribution and biological characteristics of Atlantic salmon (Salmo salar) at Greenland based on the analysis of historical tag recoveries. – ICES Journal of Marine Science, 69: 1589–1597.
Development and Validation of a Celiac Disease Quality of Life Instrument for North American Children
Authors: Jordan Nicole E. , Li Yuelin , Magrini Danielle , Simpson Suzanne , Reilly Norelle Rizkalla , DeFelice Amy R. , Sockolow Robbyn , Green Peter H.R. 
Published: May 2013

ABSTRACTObjective:Given the social constraints imposed by a gluten‐free diet, it can be hypothesized that children with celiac disease (CD) living in the United States have a reduced health‐related quality of life (HRQOL); however, there is no validated CD‐specific HRQOL instrument for children living in the United States. The goals of this study were to develop and validate a CD‐specific HRQOL instrument for children 8 to 18 years of age with CD and to report HRQOL in these children using both generic‐ and disease‐specific instruments.Methods:This was a prospective study using focus group methodology to develop a CD‐specific HRQOL instrument that was then administered to children 8 to 18 years of age with CD living throughout the United States. Instrument validation methods included construct, convergent, and divergent validities.Results:Two instruments were developed: CD‐specific pediatric HRQOL instrument (CDPQOL) 8 to 12 and CDPQOL 13 to 18. A total of 181 children with CD completed the CDPQOL as well as a comparator generic instrument. Exploratory factor analysis restructured the CDPQOL and reduced the total number of items. The CDPQOL showed a moderate agreement with the Psychosocial dimensions of the generic instrument confirming convergent validity and low‐to‐moderate agreement with the Physical Health Summary dimension of the generic instrument confirming divergent validity.Conclusions:The CDPQOL, consisting of 13 to 17 questions, is a validated instrument for the measurement of HRQOL in children 8 to 18 years of age with CD living in the United States.