bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partially Edentulous Arches: A 5‐Year Survey of Patients Treated at the Fluminense Federal University Removable Prosthodontics Clinics in Brazil
Authors: de Souza Fernanda Nunes , de Siqueira Gomes Camila , Rodrigues Alexandra Ramiro Camacho , Tiossi Rodrigo , de Gouvêa Cresus Vinicius Depes , de Almeida Cristina Costa 
Published: October 2014

AbstractPurposeThis study investigated the number and Kennedy Classification of the edentulous arches in patients treated at the Removable Partial Denture (RPD) Clinics of the Fluminense Federal University School of Dentistry (FO‐UFF) in Rio de Janeiro, Brazil, from 2005 to 2010.Materials and MethodsA cross‐sectional retrospective survey was conducted on patient record charts to identify gender, age, number, and location of the edentulous arches, and Kennedy Class type.ResultsOne hundred and forty‐six patients were analyzed for this study (96 [65.8%] women and 50 [34.2%] men). Two hundred and ninety‐two arches were analyzed: 74 arches (25%) were found with intact dentitions, 18 (6.1%) were edentulous arches, and 200 (68.8%) were partially edentulous arches. Ninety‐one patients (62.3%) needed oral rehabilitation with RPDs on one arch and 55 (37.7%) in both arches. One hundred and eight (53.2%) partially edentulous mandibles and 92 (46.8%) partially edentulous maxillae were found. Kennedy Class I was more frequent in the mandibular arch (58 patients; 29%) whereas Kennedy Class III was more frequent in the maxillary arch (40 patients; 20%). Patients aged between 51 and 60 years presented the highest percentage of partially edentulous arches (33.6%).ConclusionMandibular Kennedy Class I and maxillary Kennedy Class III presented the highest frequency in patients treated at the FO‐UFF. These results are in agreement with previous studies that evaluated the different Kennedy classes in partially edentulous arches.
Physiological performance of quails that underwent dietary and pharmacological manipulation of cholesterol
Authors: Botelho G. G. , Falbo M. K. , Ost P. R. , Czekoski Z. M. , Raviolo A. E. , Giotto F. M. , Goldoni E. C. , Morais R. N. 
Published: October 2014

SummaryThe present work evaluated whether dietary and pharmacological interference on cholesterol synthesis were capable of inducing alterations in blood and yolk cholesterol levels and the secretion of corticosterone metabolites. Forty‐five 40‐day‐old quails were divided into three experimental groups: vegetal fat diet, 2% beef fat (tallow) diet and vegetal fat diet with simvastatin administration (3.13 mg/kg/day). During all experiments, the animal weights and food consumption were recorded and blood and faecal samples (days 0, 15, 30, 45 and 60), as well as eggs (days 30, 45 and 60), were collected. Analysis of serum and yolk cholesterol was performed and faecal corticosterone levels were measured. No differences were observed on blood cholesterol or faecal corticosterone between all treatments, despite a tendency of increased cholesterol in the group with the animal fat diet. However, quails submitted to an animal fat diet displayed an increase in yolk cholesterol at day 30 of the treatment and the egg yolks of quails treated with simvastatin exhibited a decrease in cholesterol content by the end of the treatment at 60 days. These results improved the knowledge regarding the physiology of quails and offered support to other studies concerning the consequences of the pharmacological treatment and the dietary manipulation of cholesterol levels.
A Retrospective Study of 1,098 Blood Samples with Anemia from Adult Cats: Frequency, Classification, and Association with Serum Creatinine Concentration
Authors: Furman E. , Leidinger E. , Hooijberg E.H. , Bauer N. , Beddies G. , Moritz A. 
Published: October 2014

BackgroundFrequency and classification of anemia in terms of regeneration status and erythrocyte indices are not well described in cats.ObjectiveTo determine frequency and regenerative status of anemia in samples from adult cats, to assess the sensitivity and specificity of macrocytosis and hypochromasia for detecting regenerative anemia (RA), and to evaluate the association of anemia with increased serum creatinine concentration (SC).Study PopulationLaboratory records from 30,503 blood samples from cats (2003–2011).MethodsClinicopathologic data reviewed retrospectively. Anemia defined as hematocrit (Ht) ≤27%, red blood cell count (RBC) ≤5.5 × 106/μL and hemoglobin (Hb) ≤9.0 g/dL.RAdefined by manual absolute reticulocyte count >50 × 103/μL. Macrocytosis was defined as mean corpuscular volume (MCV) >55 fL and hypochromasia as mean corpuscular hemoglobin concentration (MCHC) <31 g/dL. Cutoff for increased serum creatinine concentration was 1.6 mg/dL.ResultsOverall, 1,098 of 30,503 blood samples (3.6%) from cats fulfilled criteria for anemia, 633 of 1,098 (57.7%) classified as nonregenerative (NRA) and 465 of 1,098 (42.3%) as regenerative.RBC, Ht, and Hb were significantly lower in theRAcompared toNRAgroup (P < .05). Sensitivity and specificity of the combined highMCVand lowMCHCto detect samples withRAwere 19.5 and 90.7%.SCwas increased in 572 of the 1,098 anemic samples (52.1%) and in 11,121 of 29,405 of nonanemic samples (37.8%).Conclusions and Clinical ImportanceMajority of anemic samples were classified asNRA. Anemia was more severe in cats withRA. Erythrocyte indices were not sensitive indicators ofRA.
Use of Plasma Renin Activity to Monitor Mineralocorticoid Treatment in Dogs with Primary Hypoadrenocorticism: Desoxycorticosterone Versus Fludrocortisone
Authors: Baumstark M.E. , Nussberger J. , Boretti F.S. , Baumstark M.W. , Riond B. , Reusch C.E. , Sieber‐Ruckstuhl N.S. 
Published: October 2014

BackgroundMeasurement of plasma renin activity (PRA) is the gold standard for monitoring mineralocorticoid treatment in humans with primary hypoadrenocorticism (PH).ObjectivesTo comparePRAin dogs with newly diagnosedPH, dogs with diseases mimickingPH, and healthy dogs, and evaluate measurement ofPRAto monitor therapeutic effects in dogs withPHtreated with different mineralocorticoids.AnimalsEleven dogs with newly diagnosedPH(group 1), 10 dogs with diseases mimickingPH(group 2), 21 healthy dogs (group 3), 17 dogs with treatedPH(group 4).MethodsIn group 1,PRAwas measured before treatment and at different times after initiating treatment. In groups 2 and 3,PRAwas measured at initial presentation only. In group 4, no baselinePRAwas obtained butPRAwas measured once or every 1–6 months during treatment. Mineralocorticoid treatment consisted of fludrocortisone acetate (FC) or desoxycorticosterone pivalate (DOCP).ResultsPlasma renin activity before treatment was increased in dogs withPHcompared to normal dogs and dogs with diseases mimickingPHwith median activity of 27, 0.8, and 1.0 ng/mL/h, respectively. In dogs withPH,PRAdecreased and normalized with mineralocorticoid treatment usingDOCPbut not withFC. In dogs treated withDOCP,PRAwas lower than in dogs treated withFC. Plasma sodium concentrations were higher and potassium concentrations were lower withDOCPtreatment compared toFCtreatment.Conclusion and Clinical ImportancePlasma renin activity is a reliable tool for monitoring mineralocorticoid treatment.DOCPtreatment more effectively suppressesPRAcompared toFCin dogs withPH.
PhaseIIEvaluation ofVDC‐1101 in Canine Cutaneous T‐Cell Lymphoma
Authors: Morges M.A. , Burton J.H. , Saba C.F. , Vail D.M. , Burgess K.E. , Thamm D.H. 
Published: October 2014

BackgroundCanine cutaneous T‐cell lymphoma (CTCL) is an uncommon disease for which efficacious therapies are lacking. The novel anticancer nucleotide prodrug VDC‐1101 (formerly known as GS‐9219) has shown efficacy in dogs with multicentric lymphoma. One of the observed adverse effects with this drug was a skin change characterized by hair loss, erythema, and pruritus, implying delivery of VDC‐1101 to the skin.Hypothesis/ObjectivesThe primary study objective was to identify the objective response rate (ORR) to VDC‐1101 in canineCTCL; secondary objectives included characterization of progression‐free survival (PFS) and adverse events (AEs).AnimalsTwelve dogs with chemotherapy‐naïve or relapsed, histologically and immunohistochemically confirmedCTCL.MethodsDogs received VDC‐1101 as a 30‐minute IV infusion once every 21 days. Prednisone (1 mg/kg PO q48h) was administered concurrently.ResultsIn 11 evaluable patients, responses included 1 complete response (CR), 4 partial responses (PR), 2 stable disease (SD), and 4 progressive disease for anORRof 45% and biologic response rate (CR/PR/SD) of 64%. The medianPFSwas 37.5 days (26 to >399 days), which includes 1 durable and ongoingCR(>1 year). Gastrointestinal and hematologicAEs were mild; no dogs developed grade 3 or 4AEs. Three dogs developed dermatopathies and 1 of these dogs was removed from the study as a result of thisAE.Conclusions and Clinical ImportanceVDC‐1101 has activity against canineCTCLand could provide another treatment option in a disease process with a poor prognosis.
No evidence of facilitation collapse in the Tibetan plateau
Authors: Pugnaire Francisco I. , Zhang Lin , Li Ruicheng , Luo Tianxiang 
Published: October 2014

AbstractQuestionsThe relative importance of facilitation under different environmental conditions has raised some recent controversy centred on predictions of the stress gradient hypothesis (SGH) for its apparent lack of predictive power under very stressful conditions. This criticism, however, is not widely shared nor fully supported by empirical data. We addressed whether changes in interaction intensity in plots under severe environmental stress determine an increase in facilitation and whether facilitation would expand the realized niche of some plant species.LocationFour sites differing in elevation and environmental conditions along a N–S transect in the Central Tibetan Plateau, Qinghai Province, China.MethodsWe assessed plant interaction intensity between the cushion plant, Androsace tapete, and species growing inside its canopy. We recorded species and number of individuals in cushions and in gaps, and mass of the two most frequent species in each site.ResultsInteractions ranged from competition to facilitation, depending on environmental severity. Net interaction balance followed predictions of the SGH, from competition on the relatively more mesic sites to facilitation in the relatively more stressful sites. There were no hints of facilitation collapse even though our harsher sites posed extreme conditions for plant survival. The main limiting factor seems to be temperature, as interaction intensity responded most to this factor, rather than to elevation or rainfall.ConclusionsFacilitation expanded the realized niche of some species, countering adverse environmental conditions. We found no collapse of facilitation under the most stressful conditions, even though some sites were at the edge of the distribution range for the cushion species.
Comparison of ropinirole controlled‐ and immediate‐release in Japanese patients with advanced Parkinson's disease
Authors: Hattori Nobutaka , Nishioka Hiroshi , Hasegawa Kazuko ,   the SWAN Study Investigators
Published: October 2014

AbstractBackgroundIn Japan, ropinirole controlled‐release tabletsrecently became available for Parkinson's disease.AimWe compared the efficacy and safety of ropinirole controlled‐release with ropinirole immediate‐release.MethodsWe carried out a phase III clinical trial (randomized, double‐blind, double‐dummy), in which controlled‐release (n = 156) or immediate‐release (n = 146) was given to Japanese patients with advanced Parkinson's disease under L‐dopa treatment. First, we assessed the non‐inferiority of ropinirole controlled‐release to immediate‐release at week 24 by measuring change from week 0 in total score of the Unified Parkinson's Disease Rating Scale Part III. Then, during weeks 26–32, we evaluated the safety and efficacy of patients’ switching from ropinirole immediate‐release to controlled‐release, and a subset of patients continued on ropinirole controlled‐release though week 54.ResultsThe change in the Unified Parkinson's Disease Rating Scale Part III total score at week 24 was −10.8 for the controlled‐release group and −11.1 for the immediate‐release group (adjusted mean difference: 0.34, two‐sided 95% confidence interval −1.41 to 2.09), and the upper limit of the confidence interval was less than the predefined margin of 2.5, showing the non‐inferiority of ropinirole controlled‐release to immediate‐release. The efficacy did not change after overnight switching from ropinirole immediate‐release to controlled‐release, and lasted until week 54. Adverse events were comparable between the two groups during the whole study period.ConclusionsAs adjunctive therapy to L‐dopa, ropinirole controlled‐release improved motor symptoms in Japanese patients with advanced Parkinson's disease. The overnight switch from immediate‐release to controlled‐release did not result in any unexpected adverse event.
Sjögren's syndrome with paresis of the internal branch of the superior laryngeal nerve
Authors: Nihei Yoshihiro , Ito Daisuke , Uno Kosuke , Saito Koichiro , Kameyama Kaori , Ando Makiko , Ishikawa Aiko , Takahashi Shinichi , Nogawa Shigeru , Koto Atsuo , Suzuki Norihiro 
Published: October 2014

AbstractA 46‐year‐old woman developed painful dysesthesia in her extremities and ataxic gait. She was diagnosed with Sjögren's syndrome, and her condition was diagnosed as sensory ataxic and painful neuropathy. Intravenous immunoglobulin therapy alleviated the ataxia and severe pain in her extremities. When she was 61‐years‐old, she developed dysphagia and dyspnea. Laryngoscopy showed tactile anesthesia on the epiglottis, indicating paresis of the superior laryngeal nerve. We considered that the primary cause of dysphagia was paresis of the internal branch of the superior laryngeal nerve, and carried out tracheostomy and high‐dose intravenous methylprednisolone therapy (1 g/day × 3 days). Her dysphagia and aspiration gradually improved without following oral steroid therapy. Our case is the first report of the internal branch of superior laryngeal nerve paresis as a possible cause of dysphagia and aspiration in a patient with Sjögren's syndrome. Additional cases of Sjögren's syndrome with dysphagia should be investigated to confirm our findings.
The desire of parents to be involved and present
Authors: Engström Åsa , Dicksson Eric , Contreras Pernilla 
Published: October 2014

AbstractBackgroundIntensive care of children means not only caring for a child; it means care for the whole family.AimThe aim of the study was to describe parents' experiences of having a critically ill child in an intensive care unit (ICU).ParticipantsA purposive sample of seven parents who had their child treated in an ICU during 2012 in Sweden.DesignThe design uses an inductive, qualitative approach with data collected by means of qualitative interviews.MethodsThe interviews were transcribed verbatim and subjected to qualitative content analysis.ResultsThe analysis resulted in one theme: the desire of parents to be involved and present, with four categories such as wanting to understand and know what is happening, feeling frustration about their child's care and treatment, a health care environment that arouses emotions, and needs for support and processing.ConclusionIt is of great importance to parents to be informed continuously about their child's condition and the care and treatment that are planned. This may increase parents' sense of ownership, control and security.Relevance to clinical practiceProviding answers to those questions that can be answered and being available to parents when they have questions about their critically ill child, the meaning of it all, and what the future will hold are suggested in clinical practice.
How to achieve adherence to a ventilation algorithm for critically ill children?
Authors: Duyndam Anita , Houmes Robert Jan , van Dijk Monique , Tibboel Dick , Ista Erwin 
Published: October 2014

ABSTRACTAims and objectivesTo evaluate to what extent physicians on a paediatric intensive care unit (PICU) adhered to a newly implemented ventilation algorithm.BackgroundPICUs worldwide use different ventilators with a wide variety of ventilation modes. We developed an algorithm, as part of a larger protocol, for choice of ventilation mode at time of admission.DesignThis study was performed in a level III PICU of a university children's hospital and had an uncontrolled, pre‐post test design with a period before implementation (T0) and two periods after implementation (T1 and T2).MethodsAn invasive ventilation algorithm targeted at two patient groups was implemented in October 2008. The algorithm distinguished between lung disease, in which pressure control was considered as the preferred mode, and no lung disease, in which pressure‐regulated volume control was preferred. Nurses and physicians were instructed in the use of the algorithm before implementation.ResultsDuring three test periods, a total of 507 children with a median age of 5 months [interquartile range (IQR) 0–50] on conventional invasive mechanical ventilation were included. In patients with lung disease, pre‐implementation adherence rate was 79% (67/85). At T1 it was 71% (51/72); at T2 84% (46/55). The slight improvement from T1 to T2 was statistically not significant (p = 0·092). In patients with no lung disease, the adherence rate rose statistically significantly from 66% at T0 (62/93) to 78% (79/101) at T1, and 84% at T2 (85/101) (p = 0·015).ConclusionImplementation of a new ventilation algorithm increased physicians' adherence to this ventilation algorithm and the effect was sustained over time. This was achieved by education, reminders and organizational changes such as admission of postcardiac surgery patients with protocolized nursing care including preset ventilator settings.Relevance to clinical practiceInterdisciplinary collaboration, effective communication, leadership support and organizational aspects may be effective strategies to improve adherence to protocols.
Variant parameter values—as defined by the Chicago Criteria—produced by ManoScan and a new system with Unisensor catheter
Authors: Kuribayashi S. , Iwakiri K. , Kawada A. , Kawami N. , Hoshino S. , Takenouchi N. , Hosaka H. , Shimoyama Y. , Kawamura O. , Yamada M. , Kusano M. 
Published: October 2014

AbstractBackgroundRecently reported normal values for esophageal motility obtained by high‐resolution manometry (HRM) using a system with a Unisensor catheter were significantly different from those obtained by the ManoScan®, which could result in a wrong diagnosis. To clarify whether these differences were due to system or subject differences, we compared the manometric parameter values between ManoScan and a new system with a Unisensor catheter (Starlet) in the same subjects.MethodsA total of 103 volunteers without any symptoms related to esophageal motility disorders were recruited. Esophageal HRM was performed using both the ManoScan and the Starlet in all subjects. Data from the ManoScan were analyzed using ManoView, and data from the Starlet were analyzed by a program with e‐sleeve function. Integrated relaxation pressure, distal contractile integral, contractile front velocity (CFV), intrabolus pressure, and distal latency were calculated by both analyzing programs, and the values of these parameters were compared between the two systems by a signed rank test.Key ResultsData from a total of 97 participants were analyzed. The values of all parameters, except CFV, measured by the Starlet were significantly higher than those obtained by the ManoScan (p < 0.01).Conclusions & InferencesBoth systems can measure esophageal motility appropriately; nevertheless, we confirmed that the two systems showed different values of the parameters defined by the Chicago criteria. These differences should be recognized to evaluate esophageal motility precisely.
Abnormal accumulation of intestinal fluid following ingestion of an unabsorbable carbohydrate in patients with irritable bowel syndrome: an MRI study
Authors: Undseth R. , Berstad A. , Kløw N.‐E. , Arnljot K. , Moi K. S. , Valeur J. 
Published: October 2014

AbstractBackgroundPostprandial discomfort following intake of poorly absorbable, but fermentable carbohydrates is a common complaint in patients with irritable bowel syndrome (IBS). We used lactulose as a model substance for this group of symptom triggering carbohydrates, aiming to visualize the intestinal response in IBS patients compared to healthy controls.MethodsPatients with IBS according to Rome III criteria (n = 52) and healthy controls (n = 16) underwent a lactulose challenge test. By using magnetic resonance imaging, we measured small bowel water content (SBWC), and distension (diameter) of the distal ileum and the colon, both in fasting state and 1 h after ingestion of 10 g lactulose. We recorded symptoms after lactulose ingestion.Key ResultsLactulose provoked significantly more symptoms in IBS patients than in healthy controls (p < 0.0001). SBWC increased more in the patient group compared to the control group (p = 0.0005). The postprandial diameter of the terminal ileum was larger in patients with IBS and the postprandial diameter of the ascending colon was smaller in patients with diarrhea‐predominant phenotype (IBS‐D). Symptoms were not correlated with change in SBWC (r = 0.05; p = 0.11), nor to the diameters of the terminal ileum or the colon.Conclusions & InferencesCompared to healthy controls, IBS patients developed more symptoms and had an abnormal accumulation of fluid in the small bowel in response to ingestion of the unabsorbable carbohydrate lactulose. This may be due to impaired motor activity of the small intestine or impaired function of the ileocecal segment.
Providing Care for Patients with Chronic Migraine: Diagnosis, Treatment, and Management
Authors: Dougherty Carrie , Silberstein Stephen D. 
Published: October 2014

AbstractChronic migraine, a subtype of migraine defined as ≥ 15 headache days per month for ≥ 3 months, in which ≥ 8 days per month meet criteria for migraine with or without aura or respond to migraine‐specific treatment, is a disabling, underdiagnosed, and undertreated disorder associated with significant disability, poor health‐related quality of life, and high economic burden. The keys to caring for chronic migraine patients include: (1) making a proper diagnosis; (2) identifying and eliminating exacerbating factors; (3) assessing for medication overuse (patients with chronic headache often overuse acute medications); and (4) continued management. Communication between patient and physician about treatment goals is important. The patient management guidelines presented in this article should help physicians improve treatment success and proactively address common comorbidities among their patients with chronic migraine.