bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermittent Therapy with Terbinafine for Dermatophyte Toe‐Onychomycosis: A New Approach
Authors: Alpsoy Erkan , Yilmaz Ertan , Basaran Erdal 
Published: April 2015

AbstractTerbinafine, an orally active antifungal agent of the allylamine class, is effective in the treatment of dermatophyte onycomycosis. Its pharmacologic and pharmacokinetic properties give strong support to the possibility that intermittent treatment courses may be equally effective in onychomycosis in general.The present randomized and controlled study was carried out to determine whether intermittent therapy with terbinafine was effective in dermatophyte toe‐onychomycosis. Sixty patients with mycologically proven toenail dermatophyte onychomycosis were included in the study. Patients were equally allocated to treatment groups in a random manner. Group 1 was given 250 mg/day of terbinafine for 3 months. Group 2 was given 500 mg/day of terbinafine for 7 days during the first week of each month for 3 months. Nails were examined clinically and mycologically at monthly intervals. All patients were followed up for 48 weeks after starting the treatment.Of the patients who entered the study, 24 in Group I and 23 in Group 2 were evaluable for efficacy. At the end of the follow‐up period, the cure rate (negative microscopy and culture) was 79.2% in Group 1 and 73.9% in Group 2; this difference was not significant (p: 0.79).The results indicate that intermittent therapy with terbinafine is as effective as 3‐month treatment in dermatophyte toe‐onychomycosis.
Heterotopic Salivary Glands Simulating Bronchial Cleft Fistular in the Lower Neck
Authors: Hwang Sang Min , Ahn Sung Ku , Lee Seung Hun , Lee Won Soo 
Published: April 2015

AbstractA heterotopic salivary gland (HSG) in the lower neck is an unusual developmental anomaly rarely encountered by the dermatologist. Klimko and Horanyi (1) reported the first histologically documented case of HSG in the lower neck in 1958. To our knowledge, fewer than 100 such cases have been reported in the literature to date. The origin of HSG in the lower neck seems to be closely associated with the branchial apparatus. Because this condition is rarely encountered, dermatologists should be well informed about the clinical manifestations, development of various malignancies, and the differential diagnosis of HSG.
Cutaneous Sarcoid Reactions during Long Term Remission in a Patient with Acute Myelogenous Leukemia
Authors: Isoda Midori 
Published: April 2015

AbstractA 68‐year‐old Japanese man with acute myelogenous leukemia, in long‐term remission, developed cutaneous sarcoid reactions on his trunk and extremities. This may suggest that sarcoid‐like granulomas be considered as a nonspecific cutaneous sign of underlying leukemia.
Solitary Mastocytoma Treated with Tranilast
Authors: Katoh Norito , Hirano Shinya , Yasuno Hirokazu 
Published: April 2015

AbstractTwo infants with solitary mastocytoma were treated with 5 mg/kg/day of tranilast [N‐(3‘,4‘‐dimethoxycinnamoyl)anthranilic acid], a mast cell stabilizing compound extracted from Nandina domestica. Tranilast was administered orally in three divided doses. In one infant, a topical corticosteroid was also applied in combination with the oral tranilast. Patients experienced symptomatic relief, and nodules resolved almost completely after eight weeks of treatment Tranilast therapy was continued for six months. No relapses were observed after discontinuation of therapy. We speculated that tranilast not only inhibited mast cell degranulation but also reduced the number of mast cells.
Giant Mixed Tumor of the Face
Authors: Kakuta Mie , Tsuboi Ryoji , Yamazaki Masashi , Sakuma Masahiro , Yoshikata Rie , Ogawa Hideoki 
Published: April 2015

AbstractA 35‐year‐old Japanese man consulted our clinic with an eight year history of a 6 cm diameter subcutaneous tumor on the left cheek. Hematoxylin and eosin staining of the resected section showed histology corresponding to a benign chondroid syringoma. Keratin was positive in most of the constituent cells, and S‐100 protein was positive in the cells distant from the lumens and in myxomatous cells. A benign chondroid syringoma of this size has only been very rarely reported in the literature.
Subcutaneous Granuloma Annulare with Hodgkin's Disease
Authors: Miyamoto Toru , Mihara Motoyuki 
Published: April 2015

AbstractWe report an 85‐year‐old woman with subcutaneous granuloma annulare. Three nodules developed on her scalp and sacral regions and granually increased with tenderness. Histologically, a biopsy specimen of the nodule was interpreted as subcutaneous granuloma annulare because palisading granuloma was present in the dermis and subcutaneous fatty tissue. Laboratory tests, including RA, showed no remarkable changes except for hyperglycemia and glycosuria. These nodules spontaneously regressed without medication. One year later, she noted swelling of some lymph nodules in the left axillary region. These were diagnosed as Hodgkin's disease (mixed cellularity type). She was treated with chemotherapy, but died after two months. Subcutaneous granuloma annulare which occurs suddenly in the elderly may be a dermadrome of malignant blood disease.
Multiple Malignant Eccrine Poroma and a Linear Epidermal Nevus
Authors: Hamanaka Sumiko , Otsuka Fujio 
Published: April 2015

AbstractA 68‐year‐old woman developed three reddish nodules on a linear epidermal nevus on the right arm. The nodules and linear lesion were resected. The histology revealed the two larger nodules to be eccrine porocarcinoma and the other to be eccrine poroepithelioma. The linear lesion was actually epidermal nevus. To our knowledge, this is the first description of adnexal tumors developing on epidermal nevus.
Isolated Collagenoma: A Case Report with a Review of Connective Tissue Nevi of the Collagen Type
Authors: Gautam Ram K. , Kar Hementa K. , Jain Rakesh K. , Bagga Gulshan R. , Sharma Shiv K. , Bhardwaj Minakshi 
Published: April 2015

AbstractA 22‐year‐old male had had five skin colored tumorous growths on the mid‐palm, ring and little fingers of the right hand for the last 15 years. Histopathological examination with hematoxylin and eosin and special stains confirmed the diagnosis of connective tissue nevi of collagen type. There were no associated cutaneous or systemic findings; thus the case was designated as isolated collagenoma. A review of connective tissue nevi of the collagen type is presented.
A Case of Unusual Syringoma: Unilateral Linear Distribution and Plaque Formation
Authors: Chi Hyung‐In 
Published: April 2015

AbstractWe describe a 25‐year‐old woman with syringoma, clinically manifested by unilateral linear distribution and a plaque formation. Syringoma papules are located on the extensor aspect of the left upper arm, the left antecubital fossa, and the left side of the chest. The papules distributed in linear fashion on the left upper arm, and partially formed plaques on the left upper arm and the left antecubital fossa. Syringoma must be included in the differential diagnosis of unilateral linear papular or plaque skin lesions.
A Case of Pseudovascular Adenoid Squamous Cell Carcinoma of the Skin with Spindle Cell Pattern
Authors: Yamamoto Osamu , Yasuda Hiroshi 
Published: April 2015

AbstractWe report a case of pseudovascular adenoid squamous cell carcinoma which was in the form of a dome‐shaped, cherry red tumor on the right cheek of an 86‐year‐old Japanese woman. Histologically, two types of atypical cells were identified; round cells in the upper part and spindle cells in the lower part. In the upper part, inter‐anastomosing sinusoid‐like pseudolumina were observed between the cords of the tumor cells. Immunohistochemically, the tumor cells did not express Factor VIII‐related and CD34 antigens or bind Ulex europaes I agglutinin, except for only one anti‐cytokeratin antibody. Ultrastructurally, the tumor cells contained tonofilaments and desmosomes and represented acantholysis. From the electron microscopy, possible role of capillary hyperpermeability on the acantholytic process of the neoplastic cells was suggested.
Acetylcholine Is an Inducer of Itching in Patients with Atopic Eczema
Authors: Heyer Gisela , Vogelgsang Maria , Hornstein Otto P. 
Published: April 2015

AbstractAs previous experimental studies disproved histamine as the main mediator of eliciting pruritus in atopic eczema (AE), we examined the neurocutaneous sensations in 15 patients with AE and in 15 age‐ and sex‐matched non‐atopic controls after i.c. injection of acetylcholine (Ach, 0.5 M, 20 μl) or buffered saline. The sensory perceptions were rated by the participants of the study with regard to their quality and intensity using a visual analogue scale. Simultaneously, the vascular reactions to Ach were recorded by the examinators via laser Doppler fluxmetry as well as flare and wheal planimetry. In contrast to the approximately equal flare and wheal extensions in either group, the cutaneous sensations differed significantly. The patients complained of ‘pure’ itching that developed shortly after Ach injection, whereas the control subjects reported only burning pain. Moreover, the patients perceived their sensations significantly earlier and significantly longer than did the controls. The study provides evidence that Ach plays an important role in the pathogeny of pruritus in patients with AE. Further investigations of the neuronal mechanisms involved in this atopy‐related effect of Ach have to be performed.
Keratosis Lichenoides Chronica: A Variant of Lichen Planus
Authors: Grunwald Marcelo H. , Amichai Boaz , Finkelstein Eve , Kachko Leonid 
Published: April 2015

AbstractIn order to establish a possible relationship between keratosis lichenoides chronica (KLC) and lichen planus (LP), we performed a comparative study which included routine histologic examination, electron microscopy, and direct immunohistochemical studies from one case of KLC and several patients with LP. Our findings demonstrate that KLC and LP share many similarities; their differences are mostly quantitative. In KLC, the findings are more prominent; we therefore conclude that KLC is at one end of the spectrum of LP.
A Possible Case of Eccrine Poroma Arising in Seborrheic Keratosis with Partial Intermediate Malignancy and Tumor of the Follicular Infundibulum
Authors: Akasaka Toshihide , Kon Saiichi 
Published: April 2015

AbstractAn eighty‐year‐old woman presented with a eccrine poroma that appeared to have arisen in a seborrheic keratosis lesion on the right side of her abdomen. The tumor consisted of a brownish, flat, elevated lesion with an eroded nodule at its periphery. Histopathological analysis of the flat, elevated lesion revealed benign basaloid and squamoid cells that showed acanthotic upward proliferation, suggesting a seborrheic keratosis. The eroded nodule showed irregular proliferation of slight atypical squamoid cells with, in parts, ductal structures in the upper dermis, suggesting that it was an eccrine poroma with partial intermediate malignancy. In addition to the eroded nodule, an occult tumor clinically accompanied the seborrheic keratosis. Histopathology of the occult tumor revealed fenestrated columns and cords of pale epithelial cells attached to the base of the seborrheic keratosis lesion, which was diagnosed as a tumor of the follicular infundibulum. Although reports of seborrheic keratosis transforming into a sweat gland tumor are rare, the present case suggests that seborrheic keratosis may develop into benign or malignant adnexal tumors, including sweat gland and follicular tumors. Thus, seborrheic keratosis should be considered as a possible precursor of adnexal tumor.
Progressive Decrease in Hair Diameter in Japanese with Male Pattern Baldness
Authors: Ishino Akihiro , Uzuka Makoto , Tsuji Yoshiharu , Nakanishi Jotaro , Hanzawa Norio , Imamura Sadao 
Published: April 2015

AbstractFifty‐six Japanese with male pattern baldness were evaluated for changes in their hair diameters over three years. The mean hair diameter significantly decreased each year. The average decrease was 1.1 μm per year. Although the percentage of vellus hair increased by 3.6% over three years, this increase rate was lower than that found in Caucasians. To precisely examine the change in hair diameter, the mean distribution of this diameter was investigated. At the beginning of the study, clear peaks were observed at 95 μm in the twenties and 45 μm in the fifties. The number of thicker hairs decreased and the high frequency peak shifted to a thinner hair diameter over 3 years.To quantify the change in the distribution of hair diameter, the percentage of hairs of more than 60 μm was examined. There was a statistically significant 5.61% decrease in the percentage of hairs with a diameter of more than 60 μm over three years. Our findings suggest that the progression of male pattern baldness in Japanese is slower than that of Caucasians and that the percentage of hairs of more than 60 μm is a sensitive index to evaluate the progression of male pattern baldness and the effects of hair growth or hair loss preventive agents.
Hereditary Palmoplantar Keratodermas in South India
Authors: Gulati Sanjeev , Thappa Devinder Mohan , Garg Bhagat Ram 
Published: April 2015

AbstractThirty‐one patients with inherited palmoplantar keratodermas (PPKs) were screened from 59,490 cases who visiting the OPD of JIPMER, Pondicherry. The prevalence rate was 5.2 per 10,000 population (1:2000 approx.). PPKs were more common in males (25 patients) than females (6 patients); the overall male to female ratio was 4.2:1. The incidence was highest in the group from 0–10 years of life (67.7% of cases). Unna‐Thost syndrome topped the list with 38.7% of cases and its prevalence 1:6000 (approx.), followed by Greither's disease (22.9%) and others‐Vohwinkel (3 cases), idiopathic punctate (2 cases), ichthyosis vulgaris associated PPK (2 cases) etc. This study has for the first time reported the prevalence and patterns of hereditary PPKs in South India.
Alopecia Areata Associated with Myasthenia Gravis and Thymoma: A Case of Alopecia with Marked Improvement Following Thymectomy and High Level Prednisolone Administration
Authors: Kamada Noriaki , Hatamochi Atsushi , Shinkai Hiroshi 
Published: April 2015

AbstractA 57‐year‐old Japanese woman who suffered from alopecia areata associated with myasthenia gravis (MG) and thymoma responded well to thymectomy and high doses of glucocorticosteroid administration. Several treatments for alopecia areata including administration of systemic prednisolone were attempted, but loss of hair on the scalp progressed. After thymectomy and high level glucocorticosteroid administration for MG, the lesions on the scalp improved within four weeks. Consequently, we suggest that this thymectomy and high level glucocorticosteroid administration assisted in improving the immune dysfunction causing the alopecic lesions in this patient.
Papillary Eccrine Adenoma with a Pomegranate‐like Appearance
Authors: Ambo Midori , Kumakiri Masanobu , Kobayashi Hitoshi , Ohkawara Akira 
Published: April 2015

AbstractPapillary eccrine adenoma (PEA) is a rare cutaneous tumor which histopathologically presents numerous intradermal tubular structures with inward papillary projections. Only a few cases of PEA have been reported recently. We report a case of PEA of a 58‐year‐old Japanese man. The marked hyperkeratosis and pits gave the tumor the clinical appearance of a burst‐open pomegranate. Compact hyperkeratosis within proliferated epidermis contained spiral ducts mimicking intraepidermal eccrine sweat ducts histopathologically. These keratinous structures were thought to correspond to the pores. Several tubular structures running up to the overlying thickened epidermis were observed in the upper dermis. With these findings and with immunohistochemical studies, we proposed that this tumor originated from eccrine sweat ducts.
Riehl's Melanosis‐like Eruption Associated with Sjögren's Syndrome
Authors: Miyoshi Ken , Kodama Hajime 
Published: April 2015

AbstractA 58‐year‐old Japanese female complained of facial erythema and Riehl's melanosis‐like pigmentation. Histological examination showed liquefaction degeneration of the basal cells and pigment incontinence. Direct immunofluorescence revealed no deposition of immunoglobulins or complements at the basement membrane zone. Patch test and photopatch test using cosmetics and detergents she had been using were negative. She was diagnosed with Sjögren's syndrome based upon dryness of the mouth, dense periductal infiltration of lymphocytes and plasma cells in the labial salivary gland, positive Shirmer's test, hyper‐γ‐globulinemia, positive antinuclear antibody, and positive anti‐SSA (Ro) antibody. The pigmentation gradually faded away when she protected her face from ultraviolet irradiation while continuing use of the cosmetics and detergents. Riehl's melanosis‐like eruption could be a cutaneous manifestation of Sjögren's syndrome closely related with anti‐SSA (Ro) antibody.
Clinical Implications of Basic Research on Heritable Skin Diseases
Authors: Uitto Jouni 
Published: April 2015

AbstractSpectacular success has recently been made in understanding the molecular basis of various heritable skin diseases. A prototype of such conditions is epidermolysis bullosa (EB), a heterogenous group of mechano‐bullous disorders, characterized by fragility of the skin and other specialized epithelia. The fragility of the skin in EB results from defective attachment of the epidermis to the underlying dermis due to genetic lesions within molecules of the basement membrane zone (BMZ) at the dermal‐epidermal junction. Specifically, distinct mutations have been disclosed thus far in ten different genes encoding the macromolecular components of the BMZ, and the combinations and the types of mutations as well as their positions along the altered gene products collectively reflect the phenotypic variability observed in this group of heritable skin diseases. This information has major implications for genetic counseling of families at risk for recurrence of EB in subsequent pregnancies and in future generations. Furthermore, examination of specific mutations in an affected newborn allows prognostication of the severity of the clinical outcome. Finally, mutation analyses have provided the basis to develop DNA‐based prenatal testing by chorionic villus sampling or early aminocentesis during the first trimester of gestation. Collectively, the advances on EB exemplify the potential of molecular biology for improved diagnosis and patient care of genetic skin disorders.
Immunocytochemical Characterization of Malignant Schwannoma‐derived Cells in Culture
Authors: Demitsu Toshio , Murata Satoru , Kakurai Maki , Kiyosawa Tomoharu , Yaoita Hideo 
Published: April 2015

AbstractWe recently demonstrated that cultured malignant schwannoma (MS)‐derived cells can support human skin mast cell (HSMC) survival in vitro. Cultured HSMCs were spindle‐shaped in close contact with MS‐derived cells, suggesting cell to cell interaction. To elucidate the mechanism of the enhanced HSMC survival in coculture with MS‐derived cells and the cellular interactions between HSMC and MS‐derived cells, we examined the immunocytochemical characteristics of MS‐derived cells using immunofluorescence. Morphologically, cultured MS‐derived cells were polygonal with abundant cytoplasm and resembled perineurial cells. The cultured cells immunoreacted positively with vimentin, fibronectin, laminin and collagen IV, but negatively with anti‐S100 protein, anti‐neuron specific enolase, and anti‐neurofilament (68 kd, 145 kd, 200 kd) antibodies. MS‐derived cells were distinct from Schwann cells in their lack of S100 protein and also distinguishable from endoneurial fibroblasts that produce fibronectin, but never expressed laminin or collagen IV. MS‐derived cells thus possess the characteristics of perineurial cells in their general morphology and their immunocytochemical properties.Immunoreactivity for substance P (SP) and neurokinin A (NKA) was found in the cytoplasm of these cells, particularly around the nuclei. Vasoactive intestinal peptide, somatostatin, and calcitonin gene related peptide were negative.From these findings, we characterized the MS‐derived cell's in vitro properties and concluded that it is similar to a perineurial cell. The extracellular matrix protein, laminin, and fibronectin expressed in the MS‐derived cell might contribute to HSMC survival and morphology through cell to matrix adhesion. Neuropeptides such as SP and NKA, expressed in the MS‐derived cell, might play some role in enhanced HSMC survival in vitro.
Hypergammaglobulinemic Purpura Associated with Sjögren's Syndrome and Chronic C Type Hepatitis
Authors: Yamamoto Toshiyuki , Yokoyama Akiko 
Published: April 2015

AbstractAlthough hypergammaglobulinemic purpura usually occurs secondarily on the lower legs in several disorders, purpura has also recently been reported to be associated with chronic C type hepatitis (HCV). To define the differences in the clinical, histological and laboratory findings and the prognosis of hypergammaglobulinemic purpura associated with those two disorders, we examined ten patients with hypergammaglobulinemic purpura, 6 patients with hypergammaglobulinemic purpura associated with Sjögren's syndrome (SjS) and 4 patients with hypergammaglobulinemic purpura with chronic C type hepatitis. Five of 6 patients with SjS were female. Attacks of purpura occurred in the pretibial area in all cases. Triggering factors included long walks and prolonged standing. The mean duration of attacks was 6.4 days. No systemic manifestations were associated. Anti‐Ro/SS‐A and anti‐La/SS‐B antibodies were expressed in one case. Spontaneous regression was noted in all cases; however, recurrence was noted in one. On the other hand, all the 4 patients with hypergammaglobulinemic purpura associated with HCV were men. Purpura was indurated in a few cases. Involved sites included the knee, forearm, abdomen and thigh in addition to the lower leg. The mean duration of attacks was 12.6 days. Recurrent purpura was noted in one case. Cryoglobulin was positive in three cases. In one patient with severe recurrent purpura, attacks stopped with prednisolone 10 mg/day. Histologically, leukocytoclastic vasculitis was detected in three cases associated with SjS and two cases with HCV. In conclusion, hypergammaglobulinemic purpura associated with HCV appears to occur unilaterally with a sex predilection for men and the manifestations last longer than those associated with SjS. Severe palpable purpura was also noted in association with HCV; systemic prednisolone resulted in good control.
A Case of Congenital Ectopic Nails on Bilateral Little Fingers
Authors: Iida Naoshige , Fukuya Yasuhiko , Yoshitane Katsuyuki , Hosaka Yoshiaki 
Published: April 2015

AbstractCongenital ectopic nails are a rare anomaly, but we observed a case of a 43‐year‐old woman with ectopic nails at the tips of her bilateral little fingers. On X‐ray, the distal phalanx of the each little finger appeared depressed. We surgically removed the ectopic nails. One year and 6 months later, no relapse had occurred. The histopathological examination revealed undifferentiated nail tissue including nail, nail matrix, and nail epithelium.
Primary Cutaneous Langerhans Cell Histiocytosis Treated with Photochemotherapy
Authors: Kwon Oh Sang , Cho Kwang Hyun , Song Kye Yong 
Published: April 2015

AbstractA 23‐year‐old man with Langerhans cell histiocytosis presented with asymptomatic, purplish, slightly scaly, confluent papules of one year's duration. Histological studies of biopsy specimens revealed a dense infiltrate of histiocytic mononuclear cells beneath the epidermis; these cells reacted strongly with anti‐S‐100 antibodies. Extensive investigations failed to detect systemic involvement. He was treated with repeated oral 8‐methoxypsoralen (8‐MOP) plus ultraviolet A (PUVA) therapy three times a week for two months and then once or twice with maintenance phototherapy. The lesions did not recur during the four‐month follow‐up period.