bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Cognitively Based Functional Limitations Predict Loss of Independence in Instrumental Activities of Daily Living in Older Adults
Authors: Lau Karen M. , Parikh Mili , Harvey Danielle J. , Huang Chun-Jung , Farias Sarah Tomaszewski 
Published: September 2015

AbstractOlder adults with early forms of neurodegenerative disease are at risk for functional disability, which is often defined by the loss of independence in instrumental activities of daily living (IADLs). The current study investigated the influence of mild changes in everyday functional abilities (referred to as functional limitations) on risk for development of incident functional disability. A total of 407 participants, who were considered cognitively normal or diagnosed with mild cognitive impairment (MCI) at baseline, were followed longitudinally over an average 4.1 years (range=0.8–9.2 years). Informant-based ratings from the Everyday Cognition (ECog; Farias et al., 2008) and the Instrumental Activities of Daily Living (Lawton & Brody, 1969) scales assessed the degree of functional limitations and incident IADL disability, respectively. Cox proportional hazards models revealed that more severe functional limitations (as measured by the Total ECog score) at baseline were associated with approximately a four-fold increased risk of developing IADL disability a few years later. Among the ECog domains, functional limitations in Everyday Planning, Everyday Memory, and Everyday Visuospatial domains were associated with the greatest risk of incident functional disability. These results remained robust even after controlling for participants’ neuropsychological functioning on tests of executive functions and episodic memory. Current findings indicate that early functional limitations have prognostic value in identifying older adults at risk for developing functional disability. Findings highlight the importance of developing interventions to support everyday abilities related to memory, executive function, and visuospatial skills in an effort to delay loss of independence in IADLs. (JINS, 2015,21, 688–698)
Of ‘Psychological Music’, Ciphers and Daguerreotypes: Joseph Joachim’sAbendglockenOp. 5 No. 2 (1853)
Authors: Uhde Katharina 
Published: September 2015

If as a performer and Brahms’s close collaborator Joachim promoted the music of Bach, Beethoven and Brahms, a process relatively unsympathetic to programme music of theNeudeutsche Schule, as a composer Joachim’s works do not display such an aesthetic stance. His own music, which he dubbed ‘psychological’, was intended to ‘detectandsave’, that is faithfully to perceive and record his emotions. As part of this process, Joachim’sAbendglocken, the second of theDrei Stücke, Op. 5, for violin and piano (1853), betrays a striking use of ciphers, taking Robert Schumann’s musical word games to a heightened level and using notational signs such as double bars as framing devices that suggest an intriguing link to the daguerreotypes of early photography.‘Psychological music’ describes a compositional approach Joachim pursued in the 1850s, when positivism began clashing with the existing idealist philosophy, as demonstrated in the emergence of empirical psychology from philosophy and metaphysics. Enrolled in philosophy at Göttingen University in 1853, Joachim would have encountered psychology from a pre-empirical, phenomenological perspective, which may have initiated his ‘psychological music’. The dedicatee ofAbendglockenand the constant subject of his thoughts – and arguably of his music – was Gisela von Arnim (1827–1889), daughter of Bettina von Arnim, with whom he was romantically involved and whose encrypted name – G♯–E–A – provides a valuable key to understandingAbendglockenin particular, and Joachim’s psychological music in general. This article considers the autobiographical, philosophical and cultural influences on Joachim to interpret ‘psychological music’ as it played out inAbendglocken.
Urban stress is associated with variation in microbial species composition—but not richness—in Manhattan
Authors: Reese Aspen T , Savage Amy , Youngsteadt Elsa , McGuire Krista L , Koling Adam , Watkins Olivia , Frank Steven D , Dunn Robert R 
Published: September 2015

Abstract
The biological diversity and composition of microorganisms influences both human health outcomes and ecological processes; therefore, understanding the factors that influence microbial biodiversity is key to creating healthy, functional landscapes in which to live. In general, biological diversity is predicted to be limited by habitat size, which for green areas is often reduced in cities, and by chronic disturbance (stress). These hypotheses have not previously been tested in microbial systems in direct comparison to macroorganisms. Here we analyzed bacterial, fungal and ant communities in small road medians (average area 0.0008 km2) and larger parks (average area 0.64 km2) across Manhattan (NYC). Bacterial species richness was not significantly different between medians and parks, but community composition was significantly distinct. In contrast, ant communities differed both in composition and richness with fewer ant species in medians than parks. Fungi showed no significant variation in composition or richness but had few shared taxa between habitats or sites. The diversity and composition of microbes appears less sensitive to habitat patchiness or urban stress than those of macroorganisms. Microbes and their associated ecosystem services and functions may be more resilient to the negative effects of urbanization than has been previously appreciated.
A new class of tunable hypersonic phononic crystals based on polymer-tethered colloids
Authors: Alonso-Redondo E. , Schmitt M. , Urbach Z. , Hui C. M. , Sainidou R. , Rembert P. , Matyjaszewski K. , Bockstaller M. R. , Fytas G. 
Published: September 2015

AbstractThe design and engineering of hybrid materials exhibiting tailored phononic band gaps are fundamentally relevant to innovative material technologies in areas ranging from acoustics to thermo-optic devices. Phononic hybridization gaps, originating from the anti-crossing between local resonant and propagating modes, have attracted particular interest because of their relative robustness to structural disorder and the associated benefit to ‘manufacturability’. Although hybridization gap materials are well known, their economic fabrication and efficient control of the gap frequency have remained elusive because of the limited property variability and expensive fabrication methodologies. Here we report a new strategy to realize hybridization gap materials by harnessing the ‘anisotropic elasticity’ across the particle–polymer interface in densely polymer-tethered colloidal particles. Theoretical and Brillouin scattering analysis confirm both the robustness to disorder and the tunability of the resulting hybridization gap and provide guidelines for the economic synthesis of new materials with deliberately controlled gap position and width frequencies.
Lower prefrontal activation during emotion regulation in subjects at ultrahigh risk for psychosis: an fMRI-study
Authors: van der Velde Jorien , Opmeer Esther M , Liemburg Edith J , Bruggeman Richard , Nieboer Roeline , Wunderink Lex , Aleman André 
Published: September 2015

Abstract
Background:
Previous research has shown that patients with schizophrenia experience difficulties with emotion regulation and activate prefrontal regions to a lesser extent during reappraisal of emotional information. It has been suggested that problems in emotion regulation might precede the onset of psychosis. Therefore, it could be hypothesized that also individuals at ultrahigh risk (UHR) for developing psychosis experience difficulties with emotion regulation.

Aims:
The aim of the current study was to investigate whether individuals at UHR for developing psychosis show abnormal brain activation during reappraisal of negative pictures.

Methods:
Using functional magnetic resonance imaging (fMRI), we scanned 15 UHR participants and 16 matched healthy controls while performing an emotion regulation task. During this task, participants had to reappraise their negative emotion elicited by International Affective Picture System pictures. Furthermore, the reported use of reappraisal was examined with the emotion regulation questionnaire (ERQ).

Results:
Individuals at UHR for psychosis showed less activation in the left ventrolateral prefrontal cortex during reappraisal compared with healthy controls. Furthermore, they reported less use of reappraisal in daily life (P=0.01; 95% CI (0.24–1.63)).

Conclusions:
These findings indicate that dysfunctional emotion regulation may already occur in individuals at risk for psychosis. These regulation difficulties are underpinned by less ventrolateral prefrontal cortex activation, and may result in high negative affect, lower social functioning, and high rates of psychotic symptoms.
Longitudinal risk of herpes zoster in patients with non-Hodgkin lymphoma receiving chemotherapy: A nationwide population-based study
Authors: Cho Shih-Feng , Wu Wan-Hsuan , Yang Yi-Hsin , Liu Yi-Chang , Hsiao Hui-Hua , Chang Chao-Sung 
Published: September 2015

AbstractThis study investigated the incidence of and risk factors for herpes zoster in patients with non-Hodgkin lymphoma (NHL) who were receiving anti-lymphoma treatment. The overall incidence density of herpes zoster was 12.21% (472/3865); 11.79% (258/2188) of the patients received conventional chemotherapy and 12.76% (214/1677) of the patients received rituximab-containing chemotherapy. For the patients who received conventional chemotherapy, the risk factors included female gender, multiple courses of chemotherapy and autologous hematopoietic stem cell transplantation. For the patients who received rituximab-containing chemotherapy, the risk factors included female gender, diabetes mellitus, multiple courses of chemotherapy, autologous hematopoietic stem cell transplantation and higher accumulated rituximab dose. The majority of the herpes zoster episodes occurred within the first two years after the diagnosis of NHL. After adjusting for the propensity score matching, rituximab-containing chemotherapy was not associated with a higher overall incidence density of herpes zoster (P = 0.155). However, the addition of rituximab to conventional chemotherapy increased the short-term risk of herpes zoster with adjusted odd ratios of 1.38 (95% confidence intervals (CI) = 1.05–1.81, P = 0.021) and 1.37 (95% CI = 1.08–1.73, P = 0.010) during the 1-year and 2-year follow-up periods, respectively.
Highly Flexible Self-Assembled V2O5 Cathodes Enabled by Conducting Diblock Copolymers
Authors: An Hyosung , Mike Jared , Smith Kendall A. , Swank Lisa , Lin Yen-Hao , L. Pesek Stacy , Verduzco Rafael , Lutkenhaus Jodie L. 
Published: September 2015

AbstractMechanically robust battery electrodes are desired for applications in wearable devices, flexible displays and structural energy and power. In this regard, the challenge is to balance mechanical and electrochemical properties in materials that are inherently brittle. Here, we demonstrate a unique water-based self-assembly approach that incorporates a diblock copolymer bearing electron- and ion-conducting blocks, poly(3-hexylthiophene)-block-poly(ethyleneoxide) (P3HT-b-PEO), with V2O5 to form a flexible, tough, carbon-free hybrid battery cathode. V2O5 is a promising lithium intercalation material, but it remains limited by its poor conductivity and mechanical properties. Our approach leads to a unique electrode structure consisting of interlocking V2O5 layers glued together with micellar aggregates of P3HT-b-PEO, which results in robust mechanical properties, far exceeding the those obtained from conventional fluoropolymer binders. Only 5 wt % polymer is required to triple the flexibility of V2O5 and electrodes comprised of 10 wt % polymer have unusually high toughness (293 kJ/m3) and specific energy (530 Wh/kg), both higher than reduced graphene oxide paper electrodes. Furthermore, addition of P3HT-b-PEO enhances lithium-ion diffusion, eliminates cracking during cycling and boosts cyclability relative to V2O5 alone. These results highlight the importance of tradeoffs between mechanical and electrochemical performance, where polymer content can be used to tune both aspects.
Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models
Authors: Zhu Wenfei , Li Long , Yan Zhigang , Gan Tanhuan , Li Lifeng , Chen Rirong , Chen Ruidong , Zheng Zuoyi , Hong Wenshan , Wang Jia , Smith David K. , Guan Yi , Zhu Huachen , Shu Yuelong 
Published: September 2015

AbstractThe ongoing avian H7N9 influenza outbreaks in China have caused significant human fatal cases and the virus is becoming established in poultry. Mutations with potential to increase mammalian adaptation have occurred in the polymerase basic protein 2 (PB2) and other viral genes. Here we found that dual 627K and 701N mutations could readily occur during transmission of the virus among ferrets via direct physical contact and these mutations conferred higher polymerase activity and improved viral replication in mammalian cells and enhanced virulence in mice. Special attention needs to be paid to patients with such mutations, as these may serve as an indicator of higher virus replication and increased pathogenicity.
Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides
Authors: de Tejada Guillermo Martinez , Heinbockel Lena , Ferrer-Espada Raquel , Heine Holger , Alexander Christian , Bárcena-Varela Sergio , Goldmann Torsten , Correa Wilmar , Wiesmüller Karl-Heinz , Gisch Nicolas , Sánchez-Gómez Susana , Fukuoka Satoshi , Schürholz Tobias , Gutsmann Thomas , Brandenburg Klaus 
Published: September 2015

AbstractSepsis, a life-threatening syndrome with increasing incidence worldwide, is triggered by an overwhelming inflammation induced by microbial toxins released into the bloodstream during infection. A well-known sepsis-inducing factor is the membrane constituent of Gram-negative bacteria, lipopolysaccharide (LPS), signalling via Toll-like receptor-4. Although sepsis is caused in more than 50% cases by Gram-positive and mycoplasma cells, the causative compounds are still poorly described. In contradicting investigations lipoproteins/-peptides (LP), lipoteichoic acids (LTA) and peptidoglycans (PGN), were made responsible for eliciting this pathology. Here, we used human mononuclear cells from healthy donors to determine the cytokine-inducing activity of various LPs from different bacterial origin, synthetic and natural and compared their activity with that of natural LTA and PGN. We demonstrate that LP are the most potent non-LPS pro-inflammatory toxins of the bacterial cell walls, signalling via Toll-like receptor-2, not only in vitro, but also when inoculated into mice: A synthetic LP caused sepsis-related pathological symptoms in a dose-response manner. Additionally, these mice produced pro-inflammatory cytokines characteristic of a septic reaction. Importantly, the recently designed polypeptide Aspidasept® which has been proven to efficiently neutralize LPS in vivo, inhibited cytokines induced by the various non-LPS compounds protecting animals from the pro-inflammatory activity of synthetic LP.
Electric-field control of magnetic moment in Pd
Authors: Obinata Aya , Hibino Yuki , Hayakawa Daichi , Koyama Tomohiro , Miwa Kazumoto , Ono Shimpei , Chiba Daichi 
Published: September 2015

AbstractSeveral magnetic properties have recently become tunable with an applied electric field. Particularly, electrically controlled magnetic phase transitions and/or magnetic moments have attracted attention because they are the most fundamental parameters in ferromagnetic materials. In this study, we showed that an electric field can be used to control the magnetic moment in films made of Pd, usually a non-magnetic element. Pd ultra-thin films were deposited on ferromagnetic Pt/Co layers. In the Pd layer, a ferromagnetically ordered magnetic moment was induced by the ferromagnetic proximity effect. By applying an electric field to the ferromagnetic surface of this Pd layer, a clear change was observed in the magnetic moment, which was measured directly using a superconducting quantum interference device magnetometer. The results indicate that magnetic moments extrinsically induced in non-magnetic elements by the proximity effect, as well as an intrinsically induced magnetic moments in ferromagnetic elements, as reported previously, are electrically tunable. The results of this study suggest a new avenue for answering the fundamental question of “can an electric field make naturally non-magnetic materials ferromagnetic?”
In situ formation of magnetopolymersomes via electroporation for MRI
Authors: Bain Jennifer , Ruiz-Pérez Lorena , Kennerley Aneurin J. , Muench Stephen P. , Thompson Rebecca , Battaglia Giuseppe , Staniland Sarah S. 
Published: September 2015

AbstractAs the development of diagnostic/therapeutic (and combined: theranostic) nanomedicine grows, smart drug-delivery vehicles become ever more critical. Currently therapies consist of drugs tethered to, or encapsulated within nanoparticles or vesicles. There is growing interest in functionalising them with magnetic nanoparticles (MNPs) to target the therapeutics by localising them using magnetic fields. An alternating magnetic field induces remote heating of the particles (hyperthermia) triggering drug release or cell death. Furthermore, MNPs are diagnostic MRI contrast agents. There is considerable interest in MNP embedded vehicles for nanomedicine, but their development is hindered by difficulties producing consistently monodisperse MNPs and their reliable loading into vesicles. Furthermore, it is highly advantageous to "trigger" MNP production and to tune the MNP's size and magnetic response. Here we present the first example of a tuneable, switchable magnetic delivery vehicle for nanomedical application. These are comprised of robust, tailored polymer vesicles (polymersomes) embedded with superparamagnetic magnetite MNPs (magnetopolymersomes) which show good MRI contrast (R2* = 148.8 s−1) and have a vacant core for loading of therapeutics. Critically, the magnetopolymersomes are produced by a pioneering nanoreactor method whereby electroporation triggers the in situ formation of MNPs within the vesicle membrane, offering a switchable, tuneable magnetic responsive theranostic delivery vehicle.
NMR and MALDI-TOF MS based characterization of exopolysaccharides in anaerobic microbial aggregates from full-scale reactors
Authors: Gonzalez-Gil Graciela , Thomas Ludivine , Emwas Abdul-Hamid , Lens Piet N. L. , Saikaly Pascal E. 
Published: September 2015

AbstractAnaerobic granular sludge is composed of multispecies microbial aggregates embedded in a matrix of extracellular polymeric substances (EPS). Here we characterized the chemical fingerprint of the polysaccharide fraction of EPS in anaerobic granules obtained from full-scale reactors treating different types of wastewater. Nuclear magnetic resonance (NMR) signals of the polysaccharide region from the granules were very complex, likely as a result of the diverse microbial population in the granules. Using nonmetric multidimensional scaling (NMDS), the 1H NMR signals of reference polysaccharides (gellan, xanthan, alginate) and those of the anaerobic granules revealed that there were similarities between the polysaccharides extracted from granules and the reference polysaccharide alginate. Further analysis of the exopolysaccharides from anaerobic granules and reference polysaccharides using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) revealed that exopolysaccharides from two of the anaerobic granular sludges studied exhibited spectra similar to that of alginate. The presence of sequences related to the synthesis of alginate was confirmed in the metagenomes of the granules. Collectively these results suggest that alginate-like exopolysaccharides are constituents of the EPS matrix in anaerobic granular sludge treating different industrial wastewater. This finding expands the engineered environments where alginate has been found as EPS constituent of microbial aggregates.
A sensitive optical micro-machined ultrasound sensor (OMUS) based on a silicon photonic ring resonator on an acoustical membrane
Authors: Leinders S.M. , Westerveld W.J. , Pozo J. , van Neer P.L.M.J. , Snyder B. , O’Brien P. , Urbach H.P. , de Jong N. , Verweij M.D. 
Published: September 2015

AbstractWith the increasing use of ultrasonography, especially in medical imaging, novel fabrication techniques together with novel sensor designs are needed to meet the requirements for future applications like three-dimensional intercardiac and intravascular imaging. These applications require arrays of many small elements to selectively record the sound waves coming from a certain direction. Here we present proof of concept of an optical micro-machined ultrasound sensor (OMUS) fabricated with a semi-industrial CMOS fabrication line. The sensor is based on integrated photonics, which allows for elements with small spatial footprint. We demonstrate that the first prototype is already capable of detecting pressures of 0.4 Pa, which matches the performance of the state of the art piezo-electric transducers while having a 65 times smaller spatial footprint. The sensor is compatible with MRI due to the lack of electronical wiring. Another important benefit of the use of integrated photonics is the easy interrogation of an array of elements. Hence, in future designs only two optical fibers are needed to interrogate an entire array, which minimizes the amount of connections of smart catheters. The demonstrated OMUS has potential applications in medical ultrasound imaging, non destructive testing as well as in flow sensing.
Is there an association between time of admission and in-hospital mortality in patients with non-ST-elevation myocardial infarction? A meta-analysis
Authors: Wang Xiantao , Yan Jie , Su Qiang , Sun Yuhan , Yang Huafeng , Li Lang 
Published: September 2015

AbstractWe performed a systematic review to assess whether being admitted during off-hours with non-ST-segment-elevation myocardial infarction (NSTEMI) is associated with increased in-hospital mortality. Previous studies have demonstrated an inconsistent association between patient arrival time for NSTEMI and the subsequent clinical outcomes. All studies published up to November 10, 2014 on the association between time of admission and mortality among patients with NSTEMI were identified by searching the MEDLINE, COCHRANE, EMBASE and PUBMED databases. The characteristics and outcome data of the studies included in the systematic review were extracted. Summary odds ratios (ORs) and standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Five cohort studies with a total of 129,548 patients met our inclusion criteria. The pooled analysis demonstrated that off-hours admission was not associated with increased in-hospital mortality (OR = 1.02 [95% CI (0.93–1.13)], P = 0.687). Furthermore, off-hours admission did not result in a longer door-to-balloon time (SMD = 0.37, [95%CI:−0.002 to 0.73], P = 0.051). The in-hospital mortality of patients admitted with NSTEMI during off-hours was similar to that of patients admitted during regular hours. Time of admission may not be a risk factor for increased in-hospital mortality.