bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injected biodegradable polyurethane scaffolds support tissue infiltration and delay wound contraction in a porcine excisional model
Authors: Adolph Elizabeth J. , Guo Ruijing , Pollins Alonda C. , Zienkiewicz Katarzyna , Cardwell Nancy , Davidson Jeffrey M. , Guelcher Scott A. , Nanney Lillian B. 
Published: September 2015

AbstractThe filling of wound cavities with new tissue is a challenge. We previously reported on the physical properties and wound healing kinetics of prefabricated, gas‐blown polyurethane (PUR) scaffolds in rat and porcine excisional wounds. To address the capability of this material to fill complex wound cavities, this study examined the in vitro and in vivo reparative characteristics of injected PUR scaffolds employing a sucrose porogen. Using the porcine excisional wound model, we compared reparative outcomes to both preformed and injected scaffolds as well as untreated wounds at 9, 13, and 30 days after scaffold placement. Both injected and preformed scaffolds delayed wound contraction by 19% at 9 days and 12% at 13 days compared to nontreated wounds. This stenting effect proved transient since both formulations degraded by day 30. Both types of scaffolds significantly inhibited the undesirable alignment of collagen and fibroblasts through day 13. Injected scaffolds were highly compatible with sentinel cellular events of normal wound repair cell proliferation, apoptosis, and blood vessel density. The present study provides further evidence that either injected or preformed PUR scaffolds facilitate wound healing, support tissue infiltration and matrix production, delay wound contraction, and reduce scarring in a clinically relevant animal model, which underscores their potential utility as a void‐filling platform for large cutaneous defects. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1679–1690, 2016.
Histone Acetyltransferase GCN5 Regulates Osteogenic Differentiation of Mesenchymal Stem Cells by Inhibiting NF-κB
Authors: Zhang Ping , Liu Yunsong , Jin Chanyuan , Zhang Min , Tang Fuchou , Zhou Yongsheng 
Published: September 2015

ABSTRACT

As the most well-studied histone acetyltransferase (HAT) in yeast and mammals, general control nonderepressible 5 (GCN5) was documented to play essential roles in various developmental processes. However, little is known about its role in osteogenic differentiation of mesenchymal stem cells (MSCs). Here, we detected the critical function of GCN5 in osteogenic commitment of MSCs. In this role, the HAT activity of GCN5 was not required. Mechanistically, GCN5 repressed nuclear factor kappa B (NF-κB)-dependent transcription and inhibited the NF-κB signaling pathway. The impaired osteogenic differentiation by GCN5 knockdown was blocked by inhibition of NF-κB. Most importantly, the expression of GCN5 was decreased significantly in the bone tissue sections of ovariectomized mice or aged mice. Collectively, these results may point to the GCN5-NF-κB pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis. © 2015 American Society for Bone and Mineral Research.
Large Deformation Mechanisms, Plasticity, and Failure of an Individual Collagen Fibril With Different Mineral Content
Authors: Depalle Baptiste , Qin Zhao , Shefelbine Sandra J , Buehler Markus J 
Published: September 2015

ABSTRACT

Mineralized collagen fibrils are composed of tropocollagen molecules and mineral crystals derived from hydroxyapatite to form a composite material that combines optimal properties of both constituents and exhibits incredible strength and toughness. Their complex hierarchical structure allows collagen fibrils to sustain large deformation without breaking. In this study, we report a mesoscale model of a single mineralized collagen fibril using a bottom-up approach. By conserving the three-dimensional structure and the entanglement of the molecules, we were able to construct finite-size fibril models that allowed us to explore the deformation mechanisms which govern their mechanical behavior under large deformation. We investigated the tensile behavior of a single collagen fibril with various intrafibrillar mineral content and found that a mineralized collagen fibril can present up to five different deformation mechanisms to dissipate energy. These mechanisms include molecular uncoiling, molecular stretching, mineral/collagen sliding, molecular slippage, and crystal dissociation. By multiplying its sources of energy dissipation and deformation mechanisms, a collagen fibril can reach impressive strength and toughness. Adding mineral into the collagen fibril can increase its strength up to 10 times and its toughness up to 35 times. Combining crosslinks with mineral makes the fibril stiffer but more brittle. We also found that a mineralized fibril reaches its maximum toughness to density and strength to density ratios for a mineral density of around 30%. This result, in good agreement with experimental observations, attests that bone tissue is optimized mechanically to remain lightweight but maintain strength and toughness. © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research (ASBMR).
Enhanced Efficiency of Dye–sensitized Solar Cells Based on Bulk Synthesized TiO2 Nanorods Annealed at Different Temperatures
Authors: Sayahi Hani , Hamadanian Masood , Mohsenzadeh Farshid , Aghapoor Kioumars , Kiani Mohammad Ali 
Published: September 2015

AbstractIn this study, bulk TiO2 nanorods are synthesized by hydrothermal method in order to be used in the dye‐sensitized solar cells (DSSCs). These nanorods are annealed at different temperatures and deposited electrophoretically. The influence of post heat treatment has been thoroughly investigated on fabricated DSSCs using electrochemical impedance spectroscopy (EIS). The results have revealed that the diameter, size and density of the prepared bulk nanorods are function of annealing temperatures. Optimization of the prepared DSSCs has led to an improved efficiency (ca. 3.82%) under AM 1.5 simulated sunlight.
Condensation of Aryl Aldehydes, 2‐naphthol, and Thioacetamide Catalyzed by N‐halo Reagents in Neutral Media
Authors: Khazaei Ardeshir , Abbasi Fatemeh , Moosavi‐Zare Ahmad Reza , Khazaei Marzieh , Beyzavi M. Hassan 
Published: September 2015

AbstractA new three‐component, highly efficient and solvent‐free approach for the synthesis of known and new 1‐thioamido‐alkyl‐2‐naphthol derivatives was investigated. This was achieved via a one‐pot condensation by reacting aryl aldehydes, 2‐naphthol, and thioacetamide in the presence of catalytic amount of 1,3,5‐trichloro‐1,3,5‐triazinane‐2,4,6‐trione (TCCA) and 1,3‐dichloro‐5,5‐dimethylhydantoin (DCDMH). Mechanistically, the in situ generation of Cl+ ion from TCCA and DCDMH is proposed to catalyse the reactions in neutral media. In the presented work, most of the products have been reported for the first time.
Synthesis of Novel and Thermally Stable Water Insoluble Coumarin‐based Azo Dyes via a Mild and Green Procedure
Authors: Kiani Mahtab , Karami Bahador 
Published: September 2015

AbstractA series of novel azo coumarin dyes were synthesized by the diazotization of 7‐amino coumarins in the presence of catalytic amounts of tungstate sulfuric acid (TSA) followed by coupling with phenol derivatives. Tungstate sulfuric acid catalyzes this reaction at room temperature and short reaction time with high yields.
New Cu(I) Coordination Complexes Based on Tetrathiafulvalene Substituted Triazol‐pyridine Ligand: Synthesis, Properties and Theoretical Studies
Authors: Li Gao‐Nan , He Li‐Rong , Xia Dong , Li Lin , Cheng Wen‐Feng , Li Kai‐Xiu , Cui Feng , Niu Zhi‐Gang 
Published: September 2015

AbstractTwo Cu(I) complexes based on the thioethyl‐bridged triazol‐pyridine ligand with tetrathiafulvalene unit (TTF‐TzPy, L), [Cu(I)(Binap)(L)]BF4 (5, Binap=2,2’‐bis(diphenylphosphino)‐1,1’‐binaphthyl) and [Cu(I)(Xantphos)(L)]BF4 (6, Xantphos=9,9‐dimethyl‐4,5‐bis(diphenylphosphino)‐xanthene), have been synthesized. All new compounds are characterized by elemental analyses, 1H NMR and mass spectroscopies. The complex 5 has been determined by X‐ray structure analyses which shows that the central copper (I) ion assumes distorted tetrahedral geometry. The photophysical, computational and electrochemical properties of L and 5‐6 have been investigated. The most representative molecular orbital energy‐level diagrams and the spin‐allowed singletsinglet electronic transitions of the three compounds have been calculated with density functional theory (DFT) and time‐dependent DFT (TD‐DFT). The luminescence bands of Cu(I) complexes 5‐6 have been assigned as mixed intraligand and metal‐to‐ligand charge transfer 3(MLCT+π→π*) transitions through analysis of the photophysical properties and DFT calculations. The electrochemical studies reveal that 5‐6 undergo reversible TTF/TTF+•/TTF2+ redox processes and one irreversible Cu+→Cu2+ oxidation process.
Investigation of distillation systems using heavy or intermediate entrainers for separating toluene–methanol: process economics and control
Authors: Ma Jian , Li Weisong , Ni Chunli , Li Ye , Huang Shanyuan , Shen Changlin , Xu Chunjian 
Published: September 2015

ABSTRACTBACKGROUNDThe separation of methanol–toluene by introducing aniline or triethylamine (Et3N) is investigated, with aniline and Et3N as heavy and intermediate entrainers, respectively. First, the conventional extractive distillation process with aniline as the extractive entrainer (HE) and the direct/indirect separating sequences using Et3N as intermediate entrainer (IE‐D/IE‐I) have been designed and optimized with rigorous simulations. Subsequently, the dynamic performances of these optimized processes are investigated with simple temperature control strategies. Finally, the steady‐state process economics and dynamic performances for these processes are facilitated.RESULTSThe IE‐I process has a 7.26% total annual cost (TAC) saving compared with the HE process and the total energy cost of the IE‐I process is 18.79% lower than that of the HE process. As to dynamic performances, the maximum transient deviation of the methanol product purity in the IE‐I process is much smaller than that in the HE process when ±20% feed flow rate disturbances are introduced. And when −20% step toluene composition disturbance is introduced, the new steady‐state methanol product purity in the HE process is 99.5 mol% while that in the IE‐I process is 99.8%.CONCLUSIONSThe numerical and graphic comparisons indicate that the IE‐I process possesses advantages over the HE process to some extent. The small advantages possessed by the IE‐I process are mainly those of the use of lower‐grade heat source, lower energy consumption and smaller dynamic deviations under feed disturbances. © 2015 Society of Chemical Industry
Face masks and basketball: NCAA division I consumer trends and a review of over‐the‐counter face masks
Authors: Gandy Jessica R. , Fossett Lela , Wong Brian J.F. 
Published: September 2015

Objectives/HypothesisThis study aims to: 1) determine the current consumer trends of over‐the‐counter (OTC) and custom‐made face mask usage among National Collegiate Athletic Association (NCAA) Division I athletic programs; and 2) provide a literature review of OTC face guards and a classified database.Study DesignLiterature review and survey.MethodsConsumer trends were obtained by contacting all 352 NCAA Division I programs. Athletic trainers present in the office when called answered the following questions: 1) “When an athlete breaks his or her nose, is a custom or generic face guard used?” and 2) “What brand is the generic face guard that is used?” Data was analyzed to determine trends among athletic programs. Also, a database of OTC devices available was generated using PubMed, Google, and manufacturer Web sites.ResultsAmong the 352 NCAA Division I athletic programs, 254 programs participated in the survey (72% response rate). The majority preferred custom‐made guards (46%). Disadvantages included high cost and slow manufacture turnaround time. Only 20% of the programs strictly used generic brands. For the face mask database, 10 OTC products were identified and classified into four categories based on design, with pricing ranging between $35.99 and $69.95.ConclusionOnly a handful of face masks exist for U.S. consumers, but none of them have been reviewed or classified by product design, sport application, price, and collegiate consumer use. This project details usage trends among NCAA Division I athletic programs and provides a list of available devices that can be purchased to protect the nose and face during sports.Level of EvidenceNA. Laryngoscope, 126:1054–1060, 2016
Imaging characteristics of metastatic nodes and outcomes by HPV status in head and neck cancers
Authors: Fujita Akifumi , Buch Karen , Truong Minh Tam , Qureshi Muhammad M. , Mercier Gustavo , Jalisi Scharukh , Sugimoto Hideharu , Sakai Osamu 
Published: September 2015

Objectives/HypothesisAlthough several imaging characteristics of human papillomavirus (HPV)‐related head and neck squamous cell carcinoma (HNSCC) have been reported, imaging features of nodal metastasis and influence to outcomes have not been well studied thus far. The purpose of the study was to investigate the imaging characteristics of nodal metastasis by HPV status in HNSCC and to clarify whether those findings influence the outcomes.Study DesignRetrospective review.MethodsComputed tomography and magnetic resonance imaging for initial staging on 139 patients of HNSCC with known HPV status were retrospectively reviewed. We investigated imaging characteristics of the nodal metastasis including the presence of extracapsular spread (ECS), and also investigated the influence of nodal metastasis characteristics to outcomes by HPV status. Two‐year actuarial control and survival rates were estimated using the Kaplan‐Meier product‐limit method (P < 0.05).ResultsEighty‐eight patients with nodal metastasis were identified and outcome information was available for 78 patients. Nodal metastasis was significantly more common in HPV‐positive patients compared to HPV‐negative patients (75% vs. 54%, P = 0.009). HPV‐positive patients showed a higher prevalence of ECS compared to HPV‐negative patients (77% vs. 56%, P = 0.041). The prevalence of disease recurrence was more common in HPV‐negative patients (67% vs. 13%, P < 0.0001), and it was independent of the presence of ECS in nodal metastasis.ConclusionsNodal metastases were significantly more common in HPV‐positive HNSCC, whereas the prevalence of disease recurrence was greater in HPV‐negative HNSCC. Although ECS was noted in the majority of the HPV‐positive patients with nodal metastasis, rates of recurrence were lower compared to HPV‐negative patients.Level of Evidence4. Laryngoscope, 126:392–398, 2016
Perceptual separation of sensorineural hearing loss and auditory neuropathy spectrum disorder
Authors: Wang Shuo , Dong Ruijuan , Liu Dongxin , Wang Yuan , Mao Yitao , Zhang Hua , Zhang Luo , Xu Li 
Published: September 2015

Objectives/HypothesisThe present study aimed to examine whether the response patterns to the chimeric lexical tone tokens, combined with their pure tone audiometry (PTA) results, could separate listeners with sensorineural hearing loss (SNHL) from listeners with auditory neuropathy spectrum disorder (ANSD).Study DesignCase‐control study.MethodsForty‐three SNHL subjects and 46 ANSD subjects participated in a Mandarin lexical tone perception test using original and chimeric tone tokens. Ten sets of monosyllables, with four tone patterns for each, were processed through a 16‐channel chimeric synthesizer in which a temporal envelope (E) from a monosyllabic word of one tone was paired with a fine structure (FS) from the same monosyllable of other tones.ResultsSignificantly negative correlations were present between tone perception scores and PTA0.5–4 kHz for both SNHL (P < 0.001) and ANSD (P < 0.001) subjects. Overall, 72.4%, 66.4%, and 46.3% of the tone responses were consistent with FS for the SNHL subjects with mild, moderate, and severe degree of hearing loss, respectively; and 28.4%, 23.1%, and 22.7% were consistent with FS for the ANSD subjects, with the equivalent degree of hearing loss. Similarly, 17.6%, 24.2%, and 37.7% of the tone responses were consistent with E for the SNHL subjects with mild, moderate, and severe degree of hearing loss, respectively; and 45.5%, 44.3%, and 36.5% were consistent with E for the ANSD subjects.ConclusionSubjects with SNHL and ANSD may be separated by representing their FS‐ and E‐consistent tone responses as a function of their pure‐tone hearing thresholds.Level of Evidence3b. Laryngoscope, 126:1420–1425, 2016
Vascularized tissue transfer in head and neck surgery: Is intensive care unit–based management necessary?
Authors: Panwar Aru , Smith Russell , Lydiatt Daniel , Lindau Robert , Wieland Aaron , Richards Alan , Shostrom Valerie , Militsakh Oleg , Lydiatt William 
Published: September 2015

Objectives/HypothesisTo study the impact of a non–intensive care unit (ICU)–based postoperative management strategy on patient outcomes following vascularized free tissue transfer for head and neck surgical defects.Study DesignRetrospective cohort study.MethodsThe patients consisted of two groups of adults who underwent vascularized free tissue transfer for head and neck reconstruction between July 2007 and June 2012, at an academic and a community‐based hospital. By protocol, the first group of patients had a planned admission to the intensive care unit. After creation of a designated head and neck surgical unit, the second group was cared for in a protocol driven, non‐ICU setting. Outcomes and costs were compared between the two patient groups.ResultsThere was no adverse impact on flap survival, inpatient morbidity, or mortality with the implementation of postoperative care outside of an ICU. The patients who stayed in the ICU in the immediate postoperative period had a longer median length of hospital stay (ICU vs. non‐ICU, 8 days [interquartile range {IQR} = 7–11 days] vs. 7 days [IQR = 6–9.5 days], P = .001). Median hospital charges and cost of care for patients who received ICU‐based care (US$109,367 [IQR = US$88,112–US$130,833] and US$33,642 [IQR = US$28,143–US$43,196], respectively) were significantly higher than those for non‐ICU–based care (US$86,195 [IQR = US$71,208–US$101,199] and US$28,524 [IQR = US$22,611–US$33,226], P < .0001).ConclusionsWe demonstrate that care in a non–intensive care setting following vascularized free tissue transfer is safe, less costly, and decreases length of hospital stay compared to routine intensive care–based management.Level of Evidence2c. Laryngoscope, 126:73–79, 2016
Headless: The Role of Gender and Self‐Referencing in Consumer Response to Cropped Pictures of Decorative Models
Authors: Berg Hanna 
Published: September 2015

ABSTRACTProduct pictures with “headless” decorative models, whose heads have been cropped out of the pictures, are often used in online retailing. This article reports findings from three experiments comparing attitudes for clothing displayed in pictures with cropped and uncropped male and female models, focusing on the moderating effects of consumer and model gender and the mediating effects of product self‐referencing. Results indicate that the effects on product attitudes are moderated by the gender of both models and consumers and mediated by self‐referencing. Pictures with uncropped male models result in more positive product attitudes, irrespective of consumer gender. For product pictures with female models, male consumer attitudes are also more positive for products displayed with uncropped models. In fact, attitudes are only more positive for clothing shown with cropped, “headless” models when both models and consumers are female. Implications of the findings for research and practitioners are discussed.
Synthesis of Amphiphilic Block Copolypept(o)ides by Bifunctional Initiators: Making PeptoMicelles Redox Sensitive
Authors: Holm Regina , Klinker Kristina , Weber Benjamin , Barz Matthias 
Published: September 2015

In this work, the synthesis of polypeptoid‐block‐polypeptide copolymers (block copolypept(o)ides) based on bifunctional initiators is described, which introduces a distinct chemical entity at the connection between both blocks. With a view towards redox‐sensitive block copolypept(o)ides, a cystamine‐based initiator was used to synthesize polysarcosine macroinitiators with degrees of polymerization (Xn) between 100 and 200 displaying monomodal molecular weight distributions and dispersities (Đ) around 1.1 as determined by size exclusion chromatography. Block copolypept(o)ides with a poly(γ‐t‐butyloxycarbonyl‐l‐glutamate) (PGlu(OtBu)) block (Xn = 25 or 50) were synthesized by controlled N‐carboxyanhydride polymerization. Resulting block copolymers possess monomodal molecular weight distributions, dispersities around 1.2 and were applied to degradation studies. While block copolypept(o)ides are stable at 10 × 10−6 m, they degrade over time at GSH concentrations of 10 × 10−3 and 100 × 10−3 m. Furthermore, these disulfide‐containing block copolymers form PeptoMicelles, which degrade at intracellular GSH concentrations while remaining stable at extracellular GSH levels.
image
The potential roles for adipose tissue in peripheral nerve regeneration
Authors: Walocko Frances M. , Khouri Roger K. , Urbanchek Melanie G. , Levi Benjamin , Cederna Paul S. 
Published: September 2015

IntroductionThis review summarizes current understanding about the role of adipose‐derived tissues in peripheral nerve regeneration and discusses potential advances that would translate this approach into the clinic.MethodsWe searched PubMed for in vivo, experimental studies on the regenerative effects of adipose‐derived tissues on peripheral nerve injuries. We summarized the methods and results for the 42 experiments.ResultsAdipose‐derived tissues enhanced peripheral nerve regeneration in 86% of the experiments. Ninety‐five percent evaluated purified, cultured, or differentiated adipose tissue. These approaches have regulatory and scaling burdens, restricting clinical usage. Only one experiment tested the ability of adipose tissue to enhance nerve regeneration in conjunction with nerve autografts, the clinical gold standard.ConclusionScientific studies illustrate that adipose‐derived tissues enhance regeneration of peripheral nerves. Before this approach achieves clinical acceptance, fat processing must become automated and regulatory approval achieved. Animal studies using whole fat grafts are greatly needed for clinical translation. © 2015 Wiley Periodicals, Inc. Microsurgery 36:81–88, 2016.