bluuebunny/crossref_metadata_2025_split huggingface dataset:
Krebs durch Chemikalien
Authors: Schmeiser Heinz 
Published: October 2015

AbstractDas aktive Prinzip der alten Arzneidroge Aristolochia ssp., Aristolochiasäure (AA), wurde kürzlich als Human‐Kanzerogen eingestuft. Die Aufklärung des molekularen Mechanismus der Kanzerogenese durch AA im Tier führte zu zwei spezifischen Biomarkern, die dazu benutzt wurden, eine kausale Rolle zwischen AA und Krebserkrankungen des Menschen nachzuweisen. Dabei handelt es sich um AA‐DNA‐Addukte als Biomarker der Exposition und die aus den DNA‐Addukten entstehenden AT→TA Transversionen als Biomarker des Effektes. Mit dem Nachweis beider Biomarker bei Personen, die an einer Schlankheitskur in Belgien teilgenommen hatten, sowie bei Bauern auf dem Balkan, wo Aristolochia ssp. als Unkraut in Getreidefeldern wächst, konnte AA als der Auslöser von Urothelialkrebs und einer Nierenerkrankung (AAN) identifiziert werden.
Paläogenetik der Pest
Authors: Bramanti Barbara , Hänsch Stephanie 
Published: October 2015

AbstractDie Pest begleitet unsere Geschichte seit der Antike. Immer wieder wurde sie nach Europa eingeschleppt, wo sie Millionen von Menschen das Leben kostete, bevor sie im 19. Jahrhundert aus Europa verschwand. Im Mittelalter wussten die Menschen nichts über Bakterien, auch die Übertragungswege wurden nicht immer erkannt. Die Pest galt oft als Strafe Gottes, auch wurde versucht sie über Verbreitung durch “Miasma” zu erklären. Mit modernen Methoden ist es heute Mikrobiologen und Paläogenetikern gelungen, zu beweisen, dass alle drei anerkannten Pestpandemien von Yersinia pestis verursacht wurden. Außerdem wurden wichtige Informationen über die Evolution des Pesterregers und Verbreitungswege der Pest gewonnen. Neue Daten aus laufenden paläogenetischen Studien helfen dabei, ein Licht auf die historischen Pestepidemien und vielleicht auch auf die gegenwärtige Situation zu werfen.
Ein Vogelkundemuseum als nationales Kulturerbe
Authors: Bergmann Hans‐Heiner 
Published: October 2015

AbstractLange Zeit hat das Naumann‐Museum in Köthen ein verborgenes Leben in der Provinz geführt – nur ein paar Kennern bekannt. Kürzlich aber ist es ins Licht der Öffentlichkeit getreten. Mit Schreiben vom Mai 2015 teilte das Kultusministerium des Landes Sachsen‐Anhalt mit: Das Naumann‐Museum Köthen mit allen seinen Inhalten ist in das Verzeichnis national wertvollen Kulturgutes eingetragen worden.
A history of webometrics
Authors: Thelwall Mike 
Published: October 2015

AbstractEditor's SummaryThe application of bibliometric and informetric approaches to study the web, its information resources, structures and technologies, is known as webometrics. Since the name was coined in 1997, the value of webometrics quickly became established through the Web Impact Factor, the key metric for measuring and analyzing website hyperlinks. Link analysis became more focused as link impact analysis and link network analysis, taking the quantity of links as a reflection of research productivity or prestige. Web citation analysis developed to facilitate investigations of links to journal articles, and analysis of keywords and phrases enables linking other types of web content. While webometrics is based in the theory of citation analysis, its methodology and software contributions may offer the greatest value and widest applicability. A study of the ASIS&T site demonstrates link network analysis.
JASIST 2001–2010
Authors: Bar‐Ilan Judit 
Published: October 2015

AbstractEditor's SummaryThe Journal of the American Society for Information Science and Technology (JASIST) started in 2001 after being published since 1950 under two other titles. Prior bibliometric analyses of JASIS focused on author and article characteristics and trends and on geographic and keyword distributions. The current study examines article citations from 2001 through 2010, drawing on three major citation databases and readership counts. Of 1,459 articles, 14 were cited at the top of at least one database, and seven were among both the top‐cited papers and those with the highest readership counts. The top‐cited papers focused on the web, informetrics, link analysis, theory and knowledge management. The most often read were on the web as a topic, theory, link analysis, informetrics and databases. Though not used in this research, alternative metrics such as mention counts in social media, Slideshare, Wikipedia and ReaderMeter can complement traditional citation analysis.
Systemic treatment of metastatic uveal melanoma: review of literature and future perspectives
Authors: Buder Kristina , Gesierich Anja , Gelbrich Götz , Goebeler Matthias 
Published: October 2015

AbstractUp to 50% of patients with uveal melanoma develop metastatic disease with poor prognosis. Regional, mainly liver‐directed, therapies may induce limited tumor responses but do not improve overall survival. Response rates of metastatic uveal melanoma (MUM) to systemic chemotherapy are poor. Insights into the molecular biology of MUM recently led to investigation of new drugs. In this study, to compare response rates of systemic treatment for MUM we searched Pubmed/Web of Knowledge databases and ASCO website (1980–2013) for “metastatic/uveal/melanoma” and “melanoma/eye.” Forty studies (one case series, three phase I, five pilot, 22 nonrandomized, and two randomized phase II, one randomized phase III study, data of three expanded access programs, three retrospective studies) with 841 evaluable patients were included in the numeric outcome analysis. Complete or partial remissions were observed in 39/841 patients (overall response rate [ORR] 4.6%; 95% confidence intervals [CI] 3.3–6.3%), no responses were observed in 22/40 studies. Progression‐free survival ranged from 1.8 to 7.2, median overall survival from 5.2 to 19.0 months as reported in 21/40 and 26/40 studies, respectively. Best responses were seen for chemoimmunotherapy (ORR 10.3%; 95% CI 4.8–18.7%) though mainly in first‐line patients. Immunotherapy with ipilimumab, antiangiogenetic approaches, and kinase inhibitors have not yet proven to be superior to chemotherapy. MEK inhibitors are currently investigated in a phase II trial with promising preliminary data. Despite new insights into genetic and molecular background of MUM, satisfying systemic treatment approaches are currently lacking. Study results of innovative treatment strategies are urgently awaited.
Point of purchase or point of frustration? Consumer frustration tendencies and response in a retail setting
Authors: Van Steenburg Eric , Spears Nancy , Fabrize Robert O. 
Published: October 2015

ABSTRACTThe research applies precepts from frustration theory to investigate frustration when a goal is blocked in a consumer context. Predictions are derived, and two studies are designed to investigate the goal‐directed sequence following a blocked goal and the role of individual differences in frustration tolerance in a retail checkout encounter. The findings of the research suggest that when the goal of retail checkout is blocked, consumers adopt either adaptive or maladaptive resolution strategies. Those who take an adaptive approach return to goal‐seeking behaviour, whereas those following the maladaptive path initially resolve their frustrations through resignation. That initial resolution strategy of resignation then produces a second wave of new blocks to goal attainment (helplessness, anger and self‐preoccupation). Subsequently, the second wave of blocks is countered with a second set of resolution strategies (alteration, substitution, abandonment with acceptance or abandonment with suffering). The research findings also reveal that consumer frustration responses are associated with internal versus external blame and with social surroundings or who is watching the frustrating event unfold. The results likewise indicate that attitude toward the company and repatronage intentions are influenced by social surroundings and by individual differences in frustration tolerance (fairness, entitlement, gratification and achievement). Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis, Characterization, and Biological Activities of Pendant Arm‐Pyridyltetrazole Copper(II) Complexes: DNA Binding/Cleavage Activity and Cytotoxic Studies
Authors: Mustafa Shaik , Rao Bommuluri Umamaheswara , Surendrababu Manubolu Surya , Raju Kalidindi Krishnam , Rao Gollapalli Nageswara 
Published: October 2015

Abstract2‐(1H‐Tetrazol‐5‐yl)pyridine (L) has been reacted separately with Me2NCH2CH2Cl⋅HCl and ClCH2CH2OH to yield two regioisomers in each case,N,N‐dimethyl‐2‐[5‐(pyridin‐2‐yl)‐1H‐tetrazol‐1‐yl]ethanamine (L1)/N,N‐dimethyl‐2‐[5‐(pyridin‐2‐yl)‐2H‐tetrazol‐2‐yl]ethanamine (L2) and 2‐[5‐(pyridin‐2‐yl)‐1H‐tetrazol‐1‐yl]ethanol (L3)/2‐[5‐(pyridin‐2‐yl)‐2H‐tetrazol‐2‐yl]ethanol (L4), respectively. These ligands,L1–L4, have been coordinated with CuCl2⋅H2O in 1 : 1 composition to furnish the corresponding complexes1–4. EPR Spectra of Cu complexes1and3were characteristic of square planar geometry, with nuclear hyperfine spin 3/2. Single X‐ray crystallographic studies of3revealed that the Cu center has a square planar structure. DNA binding studies were carried out by UV/VIS absorption; viscosity and thermal denaturation studies revealed that each of these complexes are avid binders of calf thymus DNA. Investigation of nucleolytic cleavage activities of the complexes was carried out on double‐stranded pBR322 circular plasmid DNA by using a gel electrophoresis experiment under various conditions, where cleavage of DNA takes place by oxidative free‐radical mechanism (OH⋅).In vitroanticancer activities of the complexes against MCF‐7 (human breast adenocarcinoma) cells revealed that the complexes inhibit the growth of cancer cells. TheIC50values of the complexes showed that Cu complexes exhibit comparable cytotoxic activities compared to the standard drug cisplatin.
Triterpenoids and Flavonoids from the Leaves of Astragalus membranaceus and Their Inhibitory Effects on Nitric Oxide Production
Authors: Wang Zhi‐Bin , Zhai Ya‐Dong , Ma Zhen‐Ping , Yang Chun‐Juan , Pan Rong , Yu Jia‐Li , Wang Qiu‐Hong , Yang Bing‐You , Kuang Hai‐Xue 
Published: October 2015

AbstractFour new cycloartane triterpenes, named huangqiyegenins V and VI and huangqiyenins K and L (1–4, resp.), together with nine known triterpenoids, 5–13, and eight flavonoids, 14–21, were isolated from a 70%‐EtOH extract of Astragalus membranaceus leaves. The structures of the new compounds were elucidated by detailed spectroscopic analyses, and the compounds were identified as (9β,11α,16β,20R,24S)‐11,16,25‐trihydroxy‐20,24‐epoxy‐9,19‐cyclolanostane‐3,6‐dione (1), (9β,16β,24S)‐16,24,25‐trihydroxy‐9,19‐cyclolanostane‐3,6‐dione (2), (3β,6α,9β,16β,20R,24R)‐16,25‐dihydroxy‐3‐(β‐D‐xylopyranosyloxy)‐20,24‐epoxy‐9,19‐cyclolanostan‐6‐yl acetate (3), and (3β,6α,9β,16β,24E)‐26‐(β‐D‐glucopyranosyloxy)‐16‐hydroxy‐3‐(β‐D‐xylopyranosyloxy)‐9,19‐cyclolanost‐24‐en‐6‐yl acetate (4). All isolated compounds were evaluated for their inhibitory activities against LPS‐induced NO production in RAW264.7 macrophage cells. Compounds 1–3, 14, 15, and 18 exhibited strong inhibition on LPS‐induced NO release by macrophages with IC50 values of 14.4–27.1 μM.
The Index Offence Representation Scales; a predictive clinical tool in the management of dangerous, violent patients with personality disorder?
Authors: McGauley Gill , Ferris Scott , Marin‐Avellan Luisa , Fonagy Peter 
Published: October 2015

AbstractBackgroundForensic mental health professionals attach considerable importance to their patient's description of his or her index offence. Despite this, there is no systematic approach to examining and formulating the patient's offence narrative.AimTo use the index offence narratives and capacity to mentalize of violent offender‐patients with personality disorder to develop a tool to predict their progress and to evaluate that tool.MethodIn a prospective, cohort study, the index offence narratives of 66 violent high security hospital patients with personality disorder were obtained from a semi‐structured interview and used to generate the Index Offence Representational Scales (IORS). The predictive validity of these scales was investigated across a range of outcome variables, controlling for the association between initial and final value of the dependent variable.ResultsThe degree to which patients held internal representations of interpersonal violence and malevolence, as measured by the IORS, predicted subsequent violent behaviour. In contrast to their actual aggressive behaviour, these patients rated themselves as having fewer symptoms on the Symptom Checklist‐90‐R (SCL‐90‐R) and fewer problems in interpersonal relationships on the Inventory of Interpersonal Problems. A more empathic victim representation on the IORS predicted better engagement with treatment.ConclusionsThe IORS show promise for helping clinicians formulate the early institutional pathway of seriously violent people with personality disorder, particularly with respect to their overt aggression and prosocial engagement. Replication studies are, however, indicated. Copyright © 2013 John Wiley & Sons, Ltd.
Probing the Metal–Support Interaction in Carbon‐Supported Catalysts by using Electron Microscopy
Authors: Zhang Bingsen , Su Dang Sheng 
Published: October 2015

AbstractCarbon is a unique and versatile element in nature that can form different architectures. Heteroatom (e.g., B, N, O, P, and S) modification has been proven to be an effective way to tailor the chemical and electrical properties of the carbon surface. Moreover, nanocarbons have been reported to be good supports for metal nanoparticles (NPs). It is essential to study the metal–support interaction between surface‐modified carbon and metal NPs to understand performance. Advanced analytical transmission electron microscopy techniques are powerful tools that can be used to probe the metal–carbon support interaction in carbon‐supported metal catalysts, as they can directly uncover local structures of the surface and the bulk of catalysts at the atomic scale and can also reveal chemical and electronic structural information that is related to their synthesis and catalytic properties significantly affecting their performance. Herein, several selected examples will be reviewed.
ChemInform Abstract: Ferroelectricity Driven by Twisting of Silicate Tetrahedral Chains.
Authors: Taniguchi Hiroki , et al. et al. 
Published: October 2015

AbstractSingle crystals of Bi2SiO5 are prepared from a mixture of Bi2O3 and SiO2 (Pt crucible, 1373 K, 2 h) and characterized by micro‐Raman scattering, powder XRD, and TEM.
ChemInform Abstract: Electronic Structure of Tantalum Oxynitride Perovskite Photocatalysts.
Authors: Balaz Snjezana , Porter Spencer H. , Woodward Patrick M. , Brillson Leonard J. 
Published: October 2015

AbstractThe absolute conduction and valence band energy levels of MTaO2N (M: Ca, Sr, Ba) and PrTaON2, which are promising candidates for photocatalytic splitting of water under visible light irradiation, are determined by a combination of XPS, Kelvin probe force microscopy, UV/VIS spectroscopy, and depth‐resolved cathodoluminescence spectroscopy.
ChemInform Abstract: Niobic Acid Nanosheets Synthesized by a Simple Hydrothermal Method as Efficient Broensted Acid Catalysts.
Authors: Fan Wenqing , Zhang Qinghong , Deng Weiping , Wang Ye 
Published: October 2015

AbstractNb2O5·xH2O nanosheets are hydrothermally synthesized from mixtures of NbCl5 dissolved in EtOH and aqueous NH3 solutions (autoclave, 513 K, 24 h).
ChemInform Abstract: Synthesis and Structural Exploration of Disulfide Bridged [2n] Pillararene‐Like Molecules.
Authors: Sonawane Mahendra P. , Jacobs Jeroen , Thomas Joice , Van Meervelt Luc , Dehaen Wim 
Published: October 2015

AbstractThe reduction of cyclic bistetrasulfide (II) and a subsequent oxidation of intermediate thiolate with air gives rise to cyclic compound (III) bearing disulfide bridges.
ChemInform Abstract: Highly Stereoselective Cyclopropanation of α,β‐Unsaturated Carbonyl Compounds with Methyl (Diazoacetoxy)acetate Catalyzed by a Chiral Ruthenium(II) Complex.
Authors: Chanthamath Soda , Takaki Suguru , Shibatomi Kazutaka , Iwasa Seiji 
Published: October 2015

AbstractThis new method gives access to intermediates, which are useful for the synthesis of bioactive compounds.
ChemInform Abstract: Construction of a Chiral Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 2‐Arylcyclohexanones under Phase‐Transfer Conditions.
Authors: Kano Taichi , Hayashi Yumi , Maruoka Keiji 
Published: October 2015

AbstractThe presence of the N,N‐diphenylaminomethylene group as a blocking group is crucial.
ChemInform Abstract: Weak Arene C—H···O Hydrogen Bonding in Palladium‐Catalyzed Arylation and Vinylation of Lactones.
Authors: Huang Zhiyan , Chen Zuliang , Lim Li Hui , Quang Gia Chuong Phan , Hirao Hajime , Zhou Jianrong 
Published: October 2015

AbstractA general method for the asymmetric synthesis of various α‐arylated lactones using chiral phosphine ligands is developed.
ChemInform Abstract: Zinc‐Catalyzed Synthesis of Functionalized Furans and Triarylmethanes from Enynones and Alcohols or Azoles: Dual X—H Bond Activation by Zinc.
Authors: Gonzales Jesus , Gonzales Javier , Perez‐Calleja Carmela , Lopez Luis A. , Vicente Ruben 
Published: October 2015

AbstractThis novel zinc‐catalyzed reaction allows the synthesis of various substituted furan derivatives by using ZnCl2 which is inexpensive and low‐toxic.
ChemInform Abstract: Regioselective Preparation of 7‐Oxanorborna‐2,5‐diene‐2,3‐dicarboxylic Acid Derivatives by the Diels—Alder Reaction: A Selective Access to Furans by Retro‐Diels—Alder Reaction.
Authors: Sultan Nisrine , Guillot Regis , Blanco Luis , Deloisy Sandrine 
Published: October 2015

AbstractA convenient approach to furan derivatives is achieved through regioselective hydrolysis of Diels—Alder adducts (III), formation of diesters or amido esters, hydrogenation, and retro‐Diels—Alder reaction.
ChemInform Abstract: Palladium‐Catalyzed Cyclocarbonylation of 2‐Halobenzaldehyde and Hydrazines: A Facile Synthesis of 2‐Aminoisoindolin‐1‐ones.
Authors: Han Chao , Shen Yang , Lu Ping , Wang Yanguang 
Published: October 2015

AbstractThe reaction proceeds with high atom efficiency and the substrates are readily available.
ChemInform Abstract: Comparative Studies on the Enantioselective Fluorination of Oxindoles with Structurally Modified N‐Fluorobenzenesulfonimides.
Authors: Yang Xian‐Jin , et al. et al. 
Published: October 2015

AbstractReactions with substituted N‐fluorobenzenesulfonimides proceed with enhanced enantioselectivity as compared to the unsubstituted parent compound.
ChemInform Abstract: Exploring the Anticancer Potential of Pyrazolo[1,2‐a]benzo[1,2,3,4]tetrazin‐3‐one Derivatives: The Effect on Apoptosis Induction, Cell Cycle and Proliferation.
Authors: Mingoia Francesco , Di Sano Caterina , Di Blasi Francesco , Fazzari Marco , Martorana Annamaria , Almerico Anna Maria , Lauria Antonino 
Published: October 2015

AbstractThe highest activity in terms of apoptosis induction is found for derivative (IVb).
ChemInform Abstract: Synthesis of Water Soluble Analogues of Arylsulfonylimidazolidinone (JSH‐2282).
Authors: Bang Seong‐Cheol , Lee Ki‐Cheul , Sharma Vinay K. , Sharma Niti , Yang Hyun‐Sun , Jung Sang‐Hun 
Published: October 2015

AbstractWater solubility of title compound (I) is remarkably increased by modifying the structure to the succinate (VIa) and pentanedioate (VIb).
ChemInform Abstract: Bi(OTf)3‐Catalyzed Solvent‐Free Synthesis of Pyrano[3,2‐c]coumarins Through a Tandem Addition/Annulation Reaction Between Chalcones and 4‐Hydroxycoumarins.
Authors: Gohain Mukut , van Tonder Johannes H. , Bezuidenhoudt Barend C. B. 
Published: October 2015

AbstractThe title reaction is a cost‐effective and environmentally benign method which produces water as the only side product.
ChemInform Abstract: Novel Synthesis of 3,3‐Bis‐(4‐chromone‐3‐ylmethyl)‐chroman‐4‐ones
Authors: Devarajan Krishnan , Balasubramanian Kalpattu K. , Bhagavathy Shanmugasundaram 
Published: October 2015

Abstractby a base‐catalyzed trimerization of 3‐hydroxymethylchromones (I)
ChemInform Abstract: A Facile Synthesis of Functionalized 1,2,6,7‐Tetrahydroimidazo[1,5‐c]pyrimidine‐3,5‐diones
Authors: Lebed Pavlo S. , Kos Pavlo O. , Tolmachev Andrey , Vovk Mykhaylo V. , Boyko Alexander N. , Chekotylo Alexey 
Published: October 2015

Abstractstarting from 6‐azidomethyl‐2‐oxo‐3,4‐dihydropyrimidine‐5‐carboxylates (I)
ChemInform Abstract: Palladium‐Catalyzed Regioselective ortho‐Acetoxylation of 3‐Aryl‐1,2,4‐benzotriazines via C—H Activation.
Authors: Ren Xiaoyu , Liu Jin , Yan Hao , Shi Xiaokang , Yang Sizhuo , Li Jian , Huang Guosheng 
Published: October 2015

AbstractA convenient protocol is developed for the reaction of benzotriazines with a stoichiometric amount of diacetoxyiodobenzene to selectively give the ortho‐monoacetoxylated products.
ChemInform Abstract: Two New Diterpenoids from Cell Cultures of Salvia miltiorrhiza
Authors: Zhang De‐Wu , Liu Xiao , Xie Dan , Chen Ridao , Tao Xiao‐Yu , Zou Jian‐Hua , Dai Jungui 
Published: October 2015

Abstractisolation, structure determination and cytotoxicity of new epi‐danshenspiroketallactone A (I) and normiltioane (II) along with 21 known compounds
ChemInform Abstract: Anti‐neuroinflammatory Diarylheptanoids from the Rhizomes of Dioscorea nipponica.
Authors: Woo Kyeong Wan , Moon Eunjung , Kwon Oh Wook , Lee Sung Ok , Kim Sun Yeou , Choi Sang Zin , Son Mi Won , Lee Kang Ro 
Published: October 2015

AbstractThe cyclic diarylheptanoids, diosniponol A (I*a) and B (I*b), are isolated along with ten known compounds from the rhizomes of Dioscorea nipponica.
ChemInform Abstract: Hierarchically Porous Co3O4 Hollow Spheres with Tunable Pore Structure and Enhanced Catalytic Activity.
Authors: Wang Chang‐An , Li Sa , An Linan 
Published: October 2015

AbstractCo3O4 hollow spheres are prepared from carbon spheres (obtained by hydrothermal treatment of aqueous glucose solutions in an autoclave at 170 °C for 10 h) dispersed in Co(NO3)2 solution, followed by calcination in Ar atmosphere at 450 °C for 2 h.
Semi‐theoretical prediction of volumetric mass transfer coefficients in bubble columns with organic liquids at ambient and elevated temperatures
Authors: Nedeltchev Stoyan , Jordan Uwe , Schumpe Adrian 
Published: October 2015

AbstractA semi‐theoretical approach for predicting kLa values (referred to liquid volume) in 18 organic liquids [acetone, aniline, 1‐butanol, benzene, cyclohexane, decalin, 1,2‐dichloroethane, 1,4‐dioxane, ethanol (96%), ethylacetate, ethylbenzene, ligroin, methanol, nitrobenzene, 2‐propanol, tetralin, toluene, and xylene] at various operating conditions (including elevated temperatures and pressures) was developed. It was found that the approach is applicable regardless of the hydrodynamic regime (at uG ≤ 0.1 m/s). Temperatures up to 353 K and pressures up to 0.5 MPa were tested. Two different distributors (multiple‐hole and single‐hole type) were employed. The liquid‐phase mass transfer coefficient kL was calculated theoretically from the penetration theory on the basis of original definition of gas–liquid contact time. The interfacial area a was defined with respect to the liquid volume. It was found that their product kLa must be multiplied by some correction factor in order to take account of the non‐spherical (ellipsoidal) shape of the bubbles. When the correction term is correlated to both the Eötvös number (Eo) and the dimensionless temperature ratio, 198 experimental kLa values can be fitted reasonably well (average relative error 9.3%).
Ir‐Catalyzed Enantioselective Hydrogenation of 2H‐1,4‐Benzoxazines with a Chiral 1,2,3,4‐Tetrahydro‐1‐naphthylamine Derived Phosphine‐aminophosphine Ligand
Authors: Hu Juan , Wang Daoyong , Zheng Zhuo , Hu Xiangping 
Published: October 2015

AbstractUnsymmetrical hybrid chiral phosphine‐aminophosphine ligand derived from 1,2,3,4‐tetrahydro‐1‐naphthylamine has been found to be highly efficient in the Ir‐catalyzed asymmetric hydrogenation of various 3‐aryl‐2H‐1,4‐benzoxazines, providing good enantioselectivities (up to 95% ee) and high catalytic activity (S/C up to 5000).