bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excellent Outcome in 238 Consecutive Living Donor Liver Transplantations Using the Right Liver Graft in a Large Volume Single Center
Authors: Yi Nam‐Joon , Suh Kyung‐Suk , Suh Suk‐Won , Chang Ye Rim , Hong Geun , Yoo Tae , Kim Hyeyoung , Park Min Su , Choi Young Rok , Lee Kwang‐Woong , Jung Chul‐Woo , Lee Jeong Hoon , Kim Yoon Jun , Yoon Jung‐Hwan , Lee Hyo‐Suk 
Published: March 2013

AbstractBackgroundUsing a right liver (RL) graft improves the outcomes in adult living donor liver transplantation (ALDLT). Here we report the recent excellent outcomes of 238 consecutive RL transplantations in ALDLT.MethodsBetween January 2005 and June 2009, 238 consecutive adult recipients underwent RL transplantation; The middle hepatic vein (MHV) was reconstructed using artificial vascular grafts in 209 cases. Among these study subjects, UNOS status 1 and 2A were 12 (5.0 %) and 20 (8.4 %) patients, and the mean medical MELD score, was 19.9. Hepatitis B virus was the most common original liver disease in 184 patients (77.3 %). Hepatocellular carcinoma was diagnosed in 133 patients (56.3 %), and 102 patients (76.1 %) met the radiologic Milan criteria. The mean graft‐versus‐recipient weight ratio was 1.14 %. The primary endpoint of this study was the patient and graft survival rate. The mean follow‐up period was 32 (0–69) months.ResultsThe most common major complication was biliary complication (n = 62; 26 %). The 1‐, 2‐, and 5‐year patient survival rates were 96, 95, and 94 %, and the graft survival rates were 99, 99, and 98 %. There were 4 hospital deaths (1.6 %). Eighteen late mortalities were observed after recurrence of hepatocellular carcinoma (HCC, n = 17) and one case of lymphoma recurrence. One case of graft failure 33 months after ALDLT was attributed to cholestatic fibrosing hepatitis B saved by re‐ALDLT. On multivariate analysis, no drainage of MHV branches and accompanying HCC beyond Milan criteria were the risk factors for poor patients’ survival rate (p < 0.05).ConclusionsFurther technical innovation would be required to overcome biliary complications. The technical innovation using right liver draining MHV branches improved both patient and graft survival outcomes of ALDLT. Despite these advances, selection criteria for HCC are still hurdles, even in RL transplantation.
Enhancing cellulase production in Trichoderma reesei RUT C30 through combined manipulation of activating and repressing genes
Authors: Wang Shaowen , Liu Gang , Wang Juan , Yu Jianteng , Huang Baiqu , Xing Miao 
Published: March 2013

Abstract
To investigate whether enzyme production can be enhanced in the Trichoderma reesei industrial hyperproducer strain RUT C30 by manipulation of cellulase regulation, the positive regulator Xyr1 was constitutively expressed under the control of the strong T. reesei pdc promoter, resulting in significantly enhanced cellulase activity in the transformant during growth on cellulose. In addition, constitutive expression of xyr1 combined with downregulation of the negative regulator encoding gene ace1 further increased cellulase and xylanase activities. Compared with RUT C30, the resulting transformant exhibited 103, 114, and 134 % greater total secreted protein levels, filter paper activity, and CMCase activity, respectively. Surprisingly, strong increases in xyr1 basal expression levels resulted in very high levels of CMCase activity during growth on glucose. These findings demonstrate the feasibility of improving cellulase production by modifying regulator expression, and suggest an attractive new single-step approach for increasing total cellulase productivity in T. reesei.
A Novel Mouse Model for Frostbite Injury
Authors: Auerbach Lauren J. , Galvez Michael G. , De Clerck Brittney K. , Glotzbach Jason , Wehner Mackenzie R. , Chang Edward I. , Gurtner Geoffrey C. , Auerbach Paul S. 
Published: March 2013

Background Frostbite injury occurs when exposure to cold results in frozen tissue. To screen drugs and other field therapies that might improve the outcome for a frostbite victim, it would be helpful to have a reliable and cost-effective preclinical in vivo model. Objective We sought to create a novel mouse skin model of induced frostbite injury. This model would allow quantification of the surface area of involved skin, histology of the wound, rate of wound healing, and skin loss in a standardized fashion after the frostbite injury. Methods Thirty-six mice were studied. Standardized 2.9-cm diameter circles were tattooed on the mouse dorsum. Magnets frozen in dry ice (−78.5°C) were used to create a frostbite injury on skin within the circle, either as a continuous 5-minute freeze or as 3 repeated freeze (1-minute) and thaw (3-minute) cycles. Appearance, healing rate, skin surface area loss, and histology were recorded until the wounds were healed. Results The amount of skin surface area loss was approximately 50% for both freeze methods. Although the time to surface skin healing was similar for both freeze methods, the initial healing rate was significantly ( P = .001) slower in mice exposed to the freeze-thaw cycles compared with the continuous freeze model. Histopathology reflected inflammatory changes, cell death, and necrosis. Conclusions This novel in vivo mouse model for frostbite allows quantification of affected skin surface area, histology, healing rate, and skin loss and has the potential of being utilized to screen future treatment modalities.
Extensions panachées autoduales
Authors: Bertrand Daniel 
Published: March 2013

AbstractWe study self-duality of Grothendieck's blended extensions in the context of a tannakian category. The set of equivalence classes of symmetric, resp. antisymmetric, blended extensions is naturally endowed with a torsor structure, which enables us to compute the unipotent radical of the associated monodromy groups in various situations.
Prime Ideals of Mixed Artin-Tate Motives
Authors: Peter Tobias J. 
Published: March 2013

AbstractWe show that for a field k, algebraic over ℚ, and F a field of characteristic zero, the triangular spectra of mixed Tate motives (resp. mixed Artin-Tate motives), denoted by DMT(k)F (resp. DMAT(k)F), are both isomorphic to spec(F). We further compute the Picard groups of DMT(k)F and DMAT(k)ℚ.
CARBON AND NUTRIENT CYCLING THROUGH FINE ROOTS IN RUBBER (HEVEA BRASILIENSIS) PLANTATIONS IN INDIA
Authors: JESSY M. D. , PRASANNAKUMARI P. , ABRAHAM JOSHUA 
Published: March 2013

SUMMARYUnderstanding the growth dynamics of fine roots and their contribution to soil organic carbon and nutrient pools is crucial for estimating ecosystem carbon and nutrient cycling and how these are influenced by climate change. Rubber is cultivated in more than 10 million hectare globally and the area under rubber cultivation is fast expanding due to socio-economic reasons, apart from the importance given to this species for eco-restoration of degraded lands. An experiment was conducted to quantify fine root production, fine root turnover and carbon and nutrient cycling through fine roots in rubber plantations with different soil nutrient status and rainfall pattern. Fine root production was estimated by sequential coring and ingrowth core methods. Fine root decomposition was determined by the litter bag technique. Carbon and nutrient contents in fine roots were determined and their turnover was computed. Fine root biomass in the top 0–7.5-cm soil layer showed significant seasonal fluctuation and the fluctuations were particularly wide during the transition period from the dry season to the rainy season. Fine root production estimated by the different methods was significantly higher at the lower fertility site and during the higher soil moisture stress year. Fine root turnover ranged from 1.04 to 2.29 year−1. Root carbon and nutrient status showed seasonal variation and lower status was observed during the rainy season. The annual recycling of C, N, P, K, Ca and Mg through fine roots ranged from 590 to 1758, 30 to 85, 3 to 12, 13 to 31, 11 to 35 and 6 to 13 kg ha−1, respectively. Substantial quantities of carbon and nutrients were recycled annually in rubber plantations through fine roots. When soil moisture and nutrient stress were more severe, fine root production, turnover and carbon and nutrient recycling through fine roots were higher.
Quantitative trait loci mapping for plant architecture traits across two upland cotton populations using SSR markers
Authors: LI C. , SONG L. , ZHAO H. , XIA Z. , JIA Z. , WANG X. , DONG N. , WANG Q. 
Published: March 2013

SUMMARYCotton plant architecture is an important agronomic trait affecting yield and quality. In the present study, two F2:3upland cotton (Gossypium hirsutumL.) populations were developed from Baimian2/TM-1 and Baimian2/CIR12 to map quantitative trait loci (QTL) for cotton plant architecture traits using simple sequence repeat (SSR) markers. A total of 73 QTL (37 significant and 36 suggestive) affecting plant architecture traits were detected in both populations. Four common QTL,qTFN-17for total fruit nodes,qFBN-17for fruit branch nodes,qFBL-17for fruit branch length andqTFB-17a/qTFB-17b(qTFB-17) for total fruit branches, were found across the two populations. These common QTL should have high reliability and could be used for marker-assisted selection (MAS) to facilitate cotton plant architecture. The two common QTL,qTFN-17andqFBL-17, were especially significant in both populations, and moreover, they explained >0·100 of the phenotypic variation in at least one population. These two QTL should be considered preferentially for MAS. The synergistic alleles and the negative alleles could be utilized in cotton plant architecture breeding programmes according to specific breeding objectives.
Fishing for Leviathans? Shifting Views on the Liberal State and Development in Peruvian History
Authors: GOOTENBERG PAUL 
Published: March 2013

AbstractThis essay examines the shifting conceptions of the state and development through recent waves of Peruvian historiography. The broad structuralist-dependency interpretations of the 1970s and 1980s gave way to a more diffuse and creative ‘political turn’ during and after the 1990s. These changing historical ideas, which still defy synthesis, relate to distinctive global conceptions and phases of economic liberalism, the changing perceived role of states in development, and the integration and social disciplining of a vastly unequal Peruvian nation. Aspects of these Peruvian historical debates may help to shed light on similar controversies through much of the region.
Towards Synthesis: Research and Discovery in Neolithic North-East England
Authors: Waddington Clive , Marshall Peter , Passmore David G. 
Published: March 2013

The Tweed Valley and its tributaries, and particularly the Milfield Basin in north Northumberland, is an area of strategic significance in the geography of the British Isles and it hosts a rich and varied multi-period archaeological and palaeoenvironmental record. This paper summarises some of the key findings for the Neolithic resulting from a long-term and in-depth landscape research project and provides a new chronological sequence for the Neolithic of the region.Attention is drawn to the discovery of what appears to be a new type of Neolithic structure associated with settlement activity hitherto unrecognised in Britain: post-built timber buildings based on a triangular arrangement of timbers. The paper then turns to a consideration of subsistence and land-use practices and the evidence for cereal agriculture from the immediate outset of the Neolithic in the region. Since 1999 many more radiocarbon measurements have become available for Neolithic activity in the area and, together with those obtained before 1999, have been recalibrated and subjected to Bayesian modelling to produce more precise estimates for Neolithic activity. Important findings include the provision of a more robust estimate for dating the onset of the Neolithic in the region, as well as establishing a chronological framework for the Neolithic–Beaker period ceramic sequence. It also reveals that the current dating available for the henge monuments indicates that this ritual complex most likely dates to the Beaker period and not to the Neolithic proper as they do in some other parts of Britain. Truly ‘Neolithic’ ceremonial monuments in the Milfield Basin remain elusive and few of the potential sites that have so far been identified have yet to be tested by excavation and scientific dating. A clear zoning of rock art is apparent, with hundreds of sites all clustered on the Fellsandstone escarpment, while a variety of Neolithic burial types is attested suggesting the region formed a meeting ground for different cultural influences.
Large outbreak of cholera caused by El Tor variant Vibrio cholerae O1 in the eastern coast of Odisha, India during 2009
Authors: PAL B. B. , KHUNTIA H. K. , SAMAL S. K. , KERKETTA A. S. , KAR S. K. , KARMAKAR M. , PATTNAIK B. 
Published: March 2013

SUMMARYA large outbreak of cholera reported during April–July 2009 in the Kendrapada district of Odisha, India was investigated. Forty-one rectal swabs and 41 water samples, collected from diarrhoeal patients and from different villages were bacteriologically analysed for the isolation of bacterial enteriopathogens, antibiogram profile and detection of various toxic genes. The bacteriological analysis of rectal swabs and environmental water samples revealed the presence of V. cholerae O1 Ogawa biotype El Tor. The V. cholerae strains were resistant to ciprofloxacin, co-trimoxazole, chloramphenicol, streptomycin, ampicillin, furazolidone and nalidixic acid. The multiplex polymerase chain reaction (PCR) assay on V. cholerae strains revealed the presence of ctxA and tcpA genes. The mismatch amplification of mutation assay (MAMA) PCR on clinical and environmental isolates of V. cholerae revealed that the strains were El Tor biotype, which harboured the ctxB gene of the classical strain. The random amplified polymorphic DNA PCR analysis and pulsed-field gel electrophoresis results indicated that the V. cholerae isolates belonged to the same clone. This investigation gives a warning that the El Tor variant of V. cholerae has spread to the coastal district causing a large outbreak that requires close monitoring and surveillance on diarrhoeal outbreaks in Odisha.
The Future of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure in Pregnant Women
Authors: Vinks AA 
Published: March 2013

Pregnant women have long been orphaned from drug studies. The application of physiologically based pharmacokinetic modeling to quantitatively describe drug disposition and effects during pregnancy is an attractive approach that is now actively pursued as it allows optimal use of available information for both efficient study designs and prediction of maternal–fetal exposure.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e33; doi:10.1038/psp.2013.9; advance online publication 6 March 2013
Low-resolution structure of the soluble domain GPAA1 (yGPAA170–247) of the glycosylphosphatidylinositol transamidase subunit GPAA1 from Saccharomyces cerevisiae
Authors: Saw Wuan Geok , Eisenhaber Birgit , Eisenhaber Frank , Grüber Gerhard 
Published: March 2013

The GPI (glycosylphosphatidylinositol) transamidase complex catalyses the attachment of GPI anchors to eukaryotic proteins in the lumen of ER (endoplasmic reticulum). The Saccharomyces cerevisiae GPI transamidase complex consists of the subunits yPIG-K (Gpi8p), yPIG-S (Gpi17p), yPIG-T (Gpi16p), yPIG-U (CDC91/GAB1) and yGPAA1. We present the production of the two recombinant proteins yGPAA170–247 and yGPAA170–339 of the luminal domain of S. cerevisiae GPAA1, covering the amino acids 70–247 and 70–339 respectively. The secondary structural content of the stable and monodisperse yGPAA170–247 has been determined to be 28% α-helix and 27% β-sheet. SAXS (small-angle X-ray scattering) data showed that yGPAA170–247 has an Rg (radius of gyration) of 2.72±0.025 nm and Dmax (maximum dimension) of 9.14 nm. These data enabled the determination of the two domain low-resolution solution structure of yGPAA170–247. The large elliptical shape of yGPAA170–247 is connected via a short stalk to the smaller hook-like domain of 0.8 nm in length and 3.5 nm in width. The topological arrangement of yGPAA170–247 will be discussed together with the recently determined low-resolution structures of yPIG-K24–337 and yPIG-S38–467 from S. cerevisiae in the GPI transamidase complex.
Information Systems History: What is History? What is is History? What is History? … and Why Even Bother with History?
Authors: Bryant Antony , Black Alistair , Land Frank , Porra Jaana 
Published: March 2013

Prologue and preamble The views of Collingwood can be summarized as follows. The philosophy of history is concerned neither with ‘the past by itself’ nor with ‘the historian's thought about it by itself’, but with ‘the two things in their mutual relations’. (This dictum reflects the two current meanings of the word ‘history’ – the inquiry conducted by the historian and the series of past events into which he inquires.) Carr (1961: 1l)
Remarkable Symmetries in the Milky Way Disc's Magnetic Field
Authors: Kronberg P. P. , Newton-McGee K. J. 
Published: March 2013

AbstractWe apply a new, expanded compilation of extragalactic source Faraday rotation measures (RM) to investigate the broad underlying magnetic structure of the Galactic disk at latitudes ∣b∣ ≲15° over all longitudes l, where our total number of RMs is comparable to those in the combined Canadian Galactic Plane Survey (CGPS) at ∣b∣ < 4° and the Southern Galactic Plane (SGPS) ∣b∣<1.5°. We report newly revealed, remarkably coherent patterns of RM at ∣b∣≲15° from l∼270° to ∼90° and RM(l) features of unprecedented clarity that replicate in l with opposite sign on opposite sides of the Galactic center. They confirm a highly patterned bisymmetric field structure toward the inner disc, an axisymmetic pattern toward the outer disc, and a very close coupling between the CGPS/SGPS RMs at ∣b∣≲3° (‘mid-plane’) and our new RMs up to ∣b∣∼15° (‘near-plane’). Our analysis also shows the vertical height of the coherent component of the disc field above the Galactic disc's mid-plane—to be ∼1.5 kpc out to ∼6 kpc from the Sun. This identifies the approximate height of a transition layer to the halo field structure. We find no RM sign change across the plane within ∣b∣∼15° in any longitude range. The prevailing disc field pattern and its striking degree of large-scale ordering confirm that our side of the Milky Way has a very organized underlying magnetic structure, for which the inward spiral pitch angle is 5.5°±1° at all ∣b∣ up to ∼12° in the inner semicircle of Galactic longitudes. It decreases to ∼0° toward the anticentre.
Stark Width Regularities within Neutral Calcium Spectral Series
Authors: Tapalaga I. , Dojčinović I. P. , Milosavljević M. K. , Purić J. 
Published: March 2013

AbstractDependences of electron and proton impact Stark width on the upper level ionization potential within different series of the neutral calcium spectral lines have been evaluated and discussed. The similar dependences previously found for the electron impact contribution were also obtained for the proton impact contribution to the Stark broadening. The emphasis is on the term structure influence on the studied Stark width dependences. The influence of the lower transition level and transition term is higher at low temperatures. After establishing these dependences, predictions were made for Stark widths of neutral calcium spectral lines not measured experimentally or calculated theoretically until now.
Distance Measurements and Stellar Population Properties via Surface Brightness Fluctuations
Authors: Fritz Alexander 
Published: March 2013

AbstractSurface Brightness Fluctuations (SBFs) are one of the most powerful techniques to measure the distance and to constrain the unresolved stellar content of extragalactic systems. For a given bandpass, the absolute SBF magnitude M depends on the properties of the underlying stellar population. Multi-band SBFs allow scientists to probe different stages of the stellar evolution: ultraviolet and blue wavelength band SBFs are sensitive to the evolution of stars within the hot horizontal branch and post-asymptotic giant branch phases, whereas optical SBF magnitudes explore the stars within the red giant branch and horizontal branch regimes. Near- and far-infrared SBF luminosities probe the important stellar evolution stage within the asymptotic giant branch and thermally pulsating asymptotic giant branch phases. Since the first successful application by Tonry and Schneider, a multiplicity of works have used this method to expand the distance scale up to 150 Mpc and beyond. This article gives a historical background of distance measurements, reviews the basic concepts of the SBF technique, presents a broad sample of investigations and discusses possible selection effects, biases, and limitations of the method. In particular, exciting new developments and improvements in the field of stellar population synthesis are discussed that are essential to understand the physics and properties of the populations in unresolved stellar systems. Further, promising future directions of the SBF technique are presented. With new upcoming space-based satellites such as Gaia, the SBF method will remain as one of the most important tools to derive distances to galaxies with unprecedented accuracy and to give detailed insights into the stellar content of globular clusters and galaxies.
Absolute-Magnitude Calibration for Red Giants Based on Colour–Magnitude Diagrams of Galactic Clusters: I. Calibration in V and B–V
Authors: Karaali S. , Bilir S. , Gökçe E. Yaz 
Published: March 2013

AbstractWe present an absolute-magnitude calibration for red giants using the colour–magnitude diagrams of six Galactic clusters with different metallicities: M92, M13, M5, 47 Tuc, M67 and NGC 6791. The combination of the absolute magnitude offset from the fiducial of giant sequence of the cluster M5 with the corresponding metallicity offset provides a calibration estimation for the absolute magnitude of red giants for a given (B – V)0 colour. The calibration is defined in the colour interval 0.75 ≤ (B – V)0 ≤ 1.50 mag and it covers the metal licity interval −2.15 > [Fe/H]≤+0.37 dex. 91% of the absolute magnitude residuals obtained by the application of the procedure to another set of Galactic clusters lie in the interval −0.40 < ΔM≤+0.40 mag. The mean and the standard deviation of the residuals are 0.05 and 0.19 mag, respectively. We fitted the absolute magnitude also to metallicity and age for a limited sub-sample of (B – V)0 colour, just to test the effect of age in absolute-magnitude calibration. Comparison of the mean and the standard deviation of the residuals evaluated by this procedure with the corresponding ones provided by the procedure where the absolute magnitude fitted to a third degree polynomial of metallicity show that the age parameter may be omitted in absolute magnitude estimation of red giants. The derived relations are applicable to stars older than 4 Gyr, the age of the youngest calibrating cluster.