bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Long-Term, High-Quality, High-Vertical-Resolution GPS Dropsonde Dataset for Hurricane and Other Studies
Authors: Wang Junhong (June) , Young Kate , Hock Terry , Lauritsen Dean , Behringer Dalton , Black Michael , Black Peter G. , Franklin James , Halverson Jeff , Molinari John , Nguyen Leon , Reale Tony , Smith Jeff , Sun Bomin , Wang Qing , Zhang Jun A. 
Published: September 2014

Abstract
A GPS dropsonde is a scientific instrument deployed from research and operational aircraft that descends through the atmosphere by a parachute. The dropsonde provides high-quality, high-vertical-resolution profiles of atmospheric pressure, temperature, relative humidity, wind speed, and direction from the aircraft flight level to the surface over oceans and remote areas. Since 1996, GPS dropsondes have been routinely dropped during hurricane reconnaissance and surveillance flights to help predict hurricane track and intensity. From 1996 to 2012, NOAA has dropped 13,681 dropsondes inside hurricane eye walls or in the surrounding environment for 120 tropical cyclones (TCs). All NOAA dropsonde data have been collected, reformatted to one format, and consistently and carefully quality controlled using state-of-the-art quality-control (QC) tools. Three value-added products, the vertical air velocity and the radius and azimuth angle of each dropsonde location, are generated and added to the dataset. As a result, a long-term (1996–2012), high-quality, high-vertical-resolution (∼5–15 m) GPS dropsonde dataset is created and made readily available for public access. The dropsonde data collected during hurricane reconnaissance and surveillance flights have improved TC-track and TC-intensity forecasts significantly. The impact of dropsonde data on hurricane studies is summarized. The scientific applications of this long-term dropsonde dataset are highlighted, including characterizing TC structures, studying TC environmental interactions, identifying surface-based ducts in the hurricane environment that affect electromagnetic wave propagation, and validating satellite temperature and humidity profiling products.
Sea Ice and Dynamical Controls on Preindustrial and Last Glacial Maximum Accumulation in Central Greenland
Authors: Rhines Andrew , Huybers Peter J. 
Published: September 2014

Abstract
Greenland has experienced large changes since the last glacial with its summit warming by approximately 21°C, average accumulation rates tripling, and annual amplitudes of temperature and accumulation seemingly declining. The altered seasonal cycle of accumulation has been attributed to a combination of the large-scale dynamical response of the North Atlantic storm track to surface boundary conditions and the modulation of moisture availability due to changes in winter sea ice cover. Using atmospheric simulations of preindustrial and glacial climate, the contributions of these two mechanisms are evaluated. Estimates of moisture source footprints make it possible to distinguish between long-range transport related to the storm track and regional transport from the ocean surface near Greenland. It is found that the contribution of both mechanisms varies significantly with the background climate. With greater ice cover and the North Atlantic storm track locked to the topographically enhanced stationary wave during the glacial, seasonal migration of the sea ice edge becomes relatively important in controlling moisture availability. In contrast, the preindustrial simulation has relatively greater transient eddy activity and is less moisture limited by sea ice extent, so accumulation is more strongly related to synoptic variability in the North Atlantic. These results highlight how changes in atmospheric circulation and sea ice together explain the shifts in annual mean and seasonal moisture supply to Greenland. Also discussed are some implications of the inferred narrow source distribution of accumulation during the glacial for the interpretation of stable isotopes derived from the central Greenland ice cores.
Numerical Simulations and Observations of Airflow through the ‘Alenuihāhā Channel, Hawaii
Authors: Hitzl David Eugene , Chen Yi-Leng , Van Nguyen Hiep 
Published: September 2014

Abstract
During the summer, sustained winds in the ‘Alenuihāhā Channel, Hawaii, may exceed 20 m s−1 with higher gusts. The Advanced Research Weather Research and Forecasting model is used to diagnose airflow in the Hawaiian coastal waters. High-resolution (2 km) runs are performed for July 2005 covering the ‘Alenuihāhā Channel and nested in a 6-km state domain. Under normal trade wind conditions (7–8 m s−1), winds at the channel entrance are 1–2 m s−1 faster than upstream due to the convergence of the deflected airflows by the islands of Maui and Hawaii, and accelerate through the channel due to along-gap pressure gradients and lower pressure in the wakes of both islands. The acceleration is accompanied by descending airflow (&gt;9 cm s−1) in the exit region with lowering of the trade wind inversion. Deceleration occurs downstream of the channel exit with a rapid change from sinking motion to rising motion (&gt;3 cm s−1). Under normal or strong trade wind conditions, the flow is subcritical [Froude number (Fr) &lt; 1] upstream of the channel, supercritical (Fr &gt; 1) in the exit region, and subcritical again (Fr &lt; 1) downstream with a weak hydraulic jump. The localized sinking motion on the lee side of bordering ridgelines (&gt;1 m s−1) is most significant in the afternoon hours and results in warming and lowering of surface pressure on the lee side, into the channel, and farther downstream. As a result, the channel winds and the wind speed maximum along the southeastern coast of Maui exhibit an afternoon maximum.
Cochlear Implant Failure and Revision Surgery in Pediatric Population
Authors: Blanchard Marion , Thierry Briac , Glynn Fergal , De Lamaze Aude , Garabédian Erea Noël , Loundon Natalie 
Published: September 2014

Objective: This study aimed to report pediatric cochlear reimplantation data focusing on failure of the device and to assess surgical challenges and functional outcomes. Methods: Retrospective case review from 1990 to 2012. Tertiary referral academic center. A retrospective review of medical and surgical records, audiologic results, and report of the manufacturer’s analysis was performed. The causes of revision cochlear implantation were divided into hard failure and soft failure. Results compared speech perception in open set or closed set words before and after revision surgery with cochlear implant only. Results: During the study period, 877 cochlear implantations were performed. Our reimplantation rate for failure of the device is 5.7% (50 of 877). The main reasons for hard failure were loss of hermeticity and cracked casing following head trauma. Surgical difficulties might be due to neo-osteogenesis related to the use of bone dust. Initial atraumatic insertion is important to ensure that revision surgeries are less problematic. In postmeningitis deafness, initial choice of electrode array is of utmost importance. We would suggest a plain shape and a larger diameter array, to ensure sufficient subsequent insertion. Post-reimplantation audiologic results were the same or better than preoperative levels in 86% of cases. Conclusion: Failure might be difficult to diagnose in children with limited language skills. The surgical team and patients should be aware of the surgical difficulties that can be encountered, especially in cases of meningitis or initial traumatic insertion. Auditory performances after reimplantation are the same or better in most cases.
The effects of modified constraint-induced movement therapy combined with trunk restraint in subacute stroke: a double-blinded randomized controlled trial
Authors: Bang Dae-Hyouk , Shin Won-Seob , Choi Sung-Jin 
Published: September 2014

Objective: To investigate the effects of a modified constraint-induced movement therapy (mCIMT) with trunk restraint in subacute stroke patients. Design: Double-blind, randomized controlled trial. Setting: Rehabilitation clinic. Participants: Eighteen subacute stroke patients with moderate motor impairment. Interventions: The patients were treated with either mCIMT combined with trunk restraint or mCIMT for 5 days per week for 4 weeks. The mCIMT combined with trunk restraint group participated in structured intervention sessions for use of the more affected upper-extremity in task-oriented activities with trunk restraint for 1 hour per day, and with the less affected upper-extremity restrained for 5 hours per day weeks. The mCIMT group followed the same protocol without trunk restraint. Main outcome measures: The outcome measures included the action research arm test (ARAT), the Fugl-Meyer assessment (FMA), the modified Barthel index (MBI), the motor activity log (MAL) and the maximal elbow extension angle during reaching (MEEAR) were completed at baseline and post intervention. Results: The mCIMT combined with trunk restraint group exhibited more improved in the ARAT, FMA, MBI, MAL and MEEAR compared with the mCIMT group. Statistical analyses showed significantly different in ARAT ( P = 0.046), FMA ( P = 0.008), MBI ( P = 0.001), MAL-AOU ( P = 0.024), MAL-QOM ( P = 0.010) and MEEAR ( P = 0.001) between groups. Conclusions: These results suggest that mCIMT combined with trunk restraint is more helpful to improve upper-extremity function than mCIMT only in subacute stroke patients with moderate motor impairment.
Triptan use in Italy: Insights from administrative databases
Authors: Da Cas Roberto , Nigro Anna , Terrazzino Salvatore , Sances Grazia , Viana Michele , Tassorelli Cristina , Nappi Giuseppe , Cargnin Sarah , Pisterna Alessia , Traversa Giuseppe , Genazzani Armando A 
Published: September 2014

Introduction In this drug utilization study, we aimed at assessing the pattern of triptan use in Italy by means of the drug prescription databases of two local health authorities, accounting for approximately 1 million citizens. Methods The study population included all residents aged 18 to 84 years in the Vercelli province (about 175,000 inhabitants) and in the Umbria region (about 885,000 inhabitants), who had at least one dispensation for triptans in 2012. A frequent user, who might be at risk of medication-overuse headache (MOH), was defined as a patient being dispensed at least 10 defined daily doses (DDD) of triptans every month for at least three consecutive months. Results Triptans were used by 0.7%–1% of the population. While most patients were dispensed fewer than 60 DDDs per year, about 10% of all triptan users were classified as frequent users. In both areas, patients below the age of 29 were less likely to be frequent users while the 40- to 49-year-old population was the most affected, with no sex difference. About two-thirds of frequent users persisted in this behavior for an additional three-month period in the following six months. Conclusions Our data indicate that approximately 10% of all triptan users in the Italian population are potentially at risk for MOH. An approach based on drug prescription databases could be useful to identify patients at risk for MOH.
Patient advocacy
Authors: Toda Yumiko , Sakamoto Masayo , Tagaya Akira , Takahashi Mimi , Davis Anne J. 
Published: September 2014

Background: Advocacy is an important role of psychiatric nurses because their patients are ethically, socially, and legally vulnerable. This study of Japanese expert psychiatric nurses’ judgments of interventions for patient advocacy will show effective strategies for ethical nursing practice and their relationship with Japanese culture. Objectives: This article explores Japanese psychiatric nurses’ decision to intervene as a patient advocate and examine their ethical, cultural, and social implications. Research design: Using semi-structured interviews verbatim, themes of the problems that required interventions were inductively summarized by a qualitative analysis and their contexts and nursing judgments were examined. Participants and research context: The participants were 21 nurses with 5 or more years of experience in psychiatric nursing. Ethical considerations: The research was approved by Institutional Review Board of research site and study facilities. The participants gave written informed consent. Findings: Analysis of 45 cases showed that nurses decided to intervene when (a) surrounding people’s opinions impeded patients’ safety, (b) healthcare professionals’ policies impeded patients’ decision-making, (c) own violent behaviors impeded treatment and welfare services for patients, (d) own or families’ low acceptance of illness impeded patients’ self-actualization, (e) inappropriate treatment or care impeded patients’ liberty, and (f) their families abused patients’ property. Discussion: To solve conflicts between patients and their surrounding people, the nurses sought reconciliation between them, which is in accordance with Japanese cultural norms respecting harmony. When necessary, however, they protected patients’ rights against cultural norms. Therefore, their judgments cannot be explained by cultural norms alone. Conclusion: The findings indicate that the nurses’ judgments were based on respect for patients’ rights apart from cultural norms, and they first sought solutions fitting the cultural norms before other solutions. This seems to be an ethical, effective strategy if advocates know the culture in depth.
Nurses’ reflections on good nurse traits
Authors: Chen Shu-Yueh , Hsu Hui-Chen 
Published: September 2014

Background: Good nurses show concern for patients by caring for them effectively and attentively to foster their well-being. However, nurses cannot be taught didactically to be “good” or any trait that characterizes a good nurse. Nurses’ self-awareness of their role traits warrants further study. Objectives: This study aimed (a) to develop a strategy to elicit nurses’ self-exploration of the importance of good nurse traits and (b) to explore any discrepancies between such role traits perceived by nurses as ideally and actually important. Research design: For this mixed-method study, we used good nurse trait card play to trigger nurses’ reflections based on clinical practice. Nurse participants appraised the ideal and actual importance of each trait using a Q-sort grid. The gap between the perceived ideal and actual importance of each trait was examined quantitatively, while trait-related clinical experiences were analyzed qualitatively. Participants and research context: Participants were 35 in-service nurses (mean age = 31.6 years (range = 23–49 years); 10.1 years of nursing experience (range = 1.5–20 years)) recruited from a teaching hospital in Taiwan. Ethical considerations: The study was approved by the Institutional Review Board of the study site. Findings: Good nurse trait card play with a Q-sort grid served as an icebreaker to help nurse participants talk about their experiences as embodied in good quality nursing care. Nurses’ perceived role–trait discrepancies were divided into three categories: over-performed, least discrepant, and under-performed. The top over-performed trait was “obedience.” Discussion: Patients’ most valued traits (“patient,” “responsible,” “cautious,” and “considerate”) were perceived by participants as ideally important but were under-performed, perhaps due to experienced nurses’ loss of idealism. Conclusion: Good nurse trait card play with Q-sort grid elicited nurses’ self-dialogue and revealed evidence of the incongruity between nurses’ perceived ideal and actual importance of traits. The top over-performed trait, “obedience,” deserves more study.
Expanding the Psychological Wellness Threshold for Black College Women
Authors: Jones Lani V. , Ahn Suran , Chan Keith T. 
Published: September 2014

Objectives: This study investigated the effectiveness of a culturally congruent group intervention program entitled “Claiming Your Connections (CYC)” aimed at reducing stress and enhancing psychosocial competence (i.e., locus of control and active coping) among Black college women. Method: Using an experimental design, a total of 96 undergraduate Black college women recruited from four predominantly White institutions and one historically Black college and university were randomly assigned to either the CYC group ( n = 49) or the wait-list control group ( n = 47). The CYC group attended 10-week group intervention sessions. Repeated measures analysis of variance was used to test intervention effects for the outcome variables. Results: After the intervention, the CYC group reported a significantly greater reduction in perceived stress and external locus of control compared to the control group. Conclusions: Counseling implications and directions for the development of future culturally relevant practice interventions with this population are discussed.
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells
Authors: Tobwala Shakila , Khayyat Ahdab , Fan Weili , Ercal Nuran 
Published: September 2014

Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyretic analgesic medications. Despite being safe at therapeutic doses, an accidental or intentional overdose can result in severe hepatotoxicity; a leading cause of drug-induced liver failure in the U.S. Depletion of glutathione (GSH) is implicated as an initiating event in APAP-induced toxicity. N-acetylcysteine (NAC), a GSH precursor, is the only currently approved antidote for an APAP overdose. Unfortunately, fairly high doses and longer treatment times are required due to its poor bioavailability. In addition, oral and intravenous administration of NAC in a hospital setting are laborious and costly. Therefore, we studied the protective effects of N-acetylcysteineamide (NACA), a novel antioxidant, with higher bioavailability and compared it with NAC in APAP-induced hepatotoxicity in a human-relevant in vitro system, HepaRG. Our results indicated that exposure of HepaRG cells to APAP resulted in GSH depletion, reactive oxygen species (ROS) formation, increased lipid peroxidation, mitochondrial dysfunction (assessed by JC-1 fluorescence), and lactate dehydrogenase release. Both NAC and NACA protected against APAP-induced hepatotoxicity by restoring GSH levels, scavenging ROS, inhibiting lipid peroxidation, and preserving mitochondrial membrane potential. However, NACA was better than NAC at combating oxidative stress and protecting against APAP-induced damage. The higher efficiency of NACA in protecting cells against APAP-induced toxicity suggests that NACA can be developed into a promising therapeutic option for treatment of an APAP overdose.
The national incidence of iatrogenic popliteal artery injury during total knee replacement
Authors: Dua Anahita , Zepeda Reyna , Hernanez Francisco C , Igbadumhe Anthony A , Desai Sapan S 
Published: September 2014

Introduction The aim of this study was to characterize national characteristics of patients who have a total knee replacement complicated by popliteal artery injury by incidence and patient demographics. Methods All patients with ICD-9 confirmed total knee replacement who had an iatrogenic popliteal artery injury were included from the national in-patient sample from 1998 to 2011. Age, gender and race, procedure type, time to popliteal artery injury, limb outcome, length of stay and hospital inpatient charges were reported. Results A total of 1,297,369 patients underwent a total knee replacement of which 43 were complicated by popliteal artery injury (0.003%); 93% had osteoarthritis as their primary diagnosis. The mean age was 61.7 ± 12.3 years. In all, 96% of patients had their popliteal injuries detected intra-operatively or on the day of total knee replacement surgery. The majority of these patients either received stent placement (44%) or peripheral bypass (30%) as their treatment modality for popliteal artery injury. There were no amputations or deaths in this cohort. The median hospital charges for this group were $27,570 (2014 USD). Conclusion The national incidence of iatrogenic popliteal artery injury in patients undergoing TKR is 0.003%. There were no amputations in our study population and 96% of patients had their injury detected intra-operative or immediately post-operatively.
Use of ultra-low-dose (≤6 mg) doxepin for treatment of insomnia in older people
Authors: Rojas-Fernandez Carlos H. , Chen Yannan 
Published: September 2014

Background: Insomnia is one of the most frequent complaints encountered in primary care practice, one that results in significant clinical consequences and cost burden to the public health system. It is more common in elderly adults (≥65 years of age), with frequent complaints regarding sleep maintenance and early morning wakening. Current treatment options have limitations. This review was conducted to evaluate the evidence behind ultra-low-dose doxepin in insomnia and to discuss its potential advantages, its place in therapy and its implications in practice in the treatment of older patients. Methods: A systematic literature search was conducted of MEDLINE via Ovid, PubMed and EMBASE using the MeSH and key terms “doxepin,” “sleep initiation and maintenance disorders,” “insomnia,” and “low dose.” Only randomized controlled trials comparing 3 mg and/or 6 mg of doxepin to placebo and involving participants diagnosed with primary insomnia were included. Primary outcomes for this review were objective sleep study parameters. Results: Five studies were identified, 3 of which ( n = 571) were conducted in older adults. Doxepin 3 mg and 6 mg significantly reduced waking after sleep onset and increased total sleep time. There was no significant difference between the 2 doses of doxepin. Latency to persistent sleep did not differ significantly compared with placebo for any doses of doxepin. The most frequent adverse events reported were somnolence and headache. Adverse events did not appear to be dose-related, and studies reported the incidence of adverse effects to be comparable to placebo. Conclusion: Doxepin 3 mg and 6 mg significantly improved and sustained sleep maintenance and sleep duration into the last third of the night but did not significantly affect sleep onset. Sleep benefits were achieved without next-day residual or discontinuation effects. Doxepin appears to be well suited for managing insomnia in older people.
Evaluation of a free amino acid–based formula in infants with presumptive food protein–induced proctocolitis
Authors: Borschel Marlene W , Antonson Dean L , Murray Nancy D , Oliva-Hemker Maria , Mattis Lynn E , Baggs Geraldine E 
Published: September 2014

Objective: Food protein–induced proctocolitis usually occurs early in life and is characterized by blood-streaked stools and pain during defecation in an otherwise healthy infant. While many infants with food protein–induced proctocolitis respond well to a casein hydrolysate formula, some require an amino acid–based formula. The objective of the study was to measure the change in physician-rated symptom score from enrollment to study completion in infants with presumptive food protein–induced proctocolitis fed with a specific amino acid-based formula. Methods: In this study, infants ≤6 months of age diagnosed with presumptive food protein–induced proctocolitis received an amino acid-based formula for 42 days. Intake, stool patterns, weight, stool occult blood, and questionnaires assessing infant feeding and stool patterns and parental formula satisfaction were collected. Results: The full analysis set included 43 infants. The mean age at enrollment was 59 ± 5 days. A significant improvement was observed from enrollment to exit in physician-rated symptom score (9.1 ± 0.5 to 4.8 ± 0.5, p < 0.0001), the number of infants with occult blood in stool, and weight-for-age Z-scores during the study. Parental satisfaction with the formula was high. Conclusion: The results confirm that the amino acid-based formula studied is efficacious for managing symptoms of presumptive food protein–induced proctocolitis.