bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paternal Depression in the Postnatal Period and Child Development: Mediators and Moderators
Authors: Gutierrez-Galve Leticia , Stein Alan , Hanington Lucy , Heron Jon , Ramchandani Paul 
Published: January 2015

OBJECTIVE:
To explore potential mediating and moderating factors that influence the association between paternal depression in the postnatal period and subsequent child behavioral and emotional problems.

METHODS:
A population-based cohort (N = 13 822) from the Avon Longitudinal Study of Parents and Children (ALSPAC) was recruited during pregnancy. Paternal and maternal depressive symptoms were assessed with the Edinburgh Postnatal Depression Scale at 8 weeks after the birth of the child. Child outcomes were assessed at 3.5 years by using the Rutter revised preschool scales and at 7 years by using the Strengths and Difficulties Questionnaire. Path analysis was used to assess hypothesized mediators (ie, depression in the other parent, couple conflict, and paternal noninvolvement) of the associations between both paternal and maternal depression and child outcomes. We also tested for hypothesized moderators (ie, paternal education and antisocial traits).

RESULTS:
Family factors (maternal depression and couple conflict) mediated two-thirds of the overall association between paternal depression and child outcomes at 3.5 years. Similar findings were seen when children were 7 years old. In contrast, family factors mediated less than one-quarter of the association between maternal depression and child outcomes. There was no evidence of moderating effects of either parental education or antisocial traits.

CONCLUSIONS:
The majority of the association between depression in fathers postnatally and subsequent child behavior is explained by the mediating role of family environment, whereas the association between depression in mothers and child outcomes appears to be better explained by other factors, perhaps including direct mother-infant interaction.
Genomic Classifier ColoPrint Predicts Recurrence in Stage II Colorectal Cancer Patients More Accurately Than Clinical Factors
Authors: Kopetz Scott , Tabernero Josep , Rosenberg Robert , Jiang Zhi-Qin , Moreno Víctor , Bachleitner-Hofmann Thomas , Lanza Giovanni , Stork-Sloots Lisette , Maru Dipen , Simon Iris , Capellà Gabriel , Salazar Ramon 
Published: January 2015

Abstract

Background.
Approximately 20% of patients with stage II colorectal cancer will experience a relapse. Current clinical-pathologic stratification factors do not allow clear identification of these high-risk patients. ColoPrint (Agendia, Amsterdam, The Netherlands, http://www.agendia.com) is a gene expression classifier that distinguishes patients with low or high risk of disease relapse.

Methods.
ColoPrint was developed using whole-genome expression data and validated in several independent validation cohorts. Stage II patients from these studies were pooled (n = 416), and ColoPrint was compared with clinical risk factors described in the National Comprehensive Cancer Network (NCCN) 2013 Guidelines for Colon Cancer. Median follow-up was 81 months. Most patients (70%) did not receive adjuvant chemotherapy. Risk of relapse (ROR) was defined as survival until first event of recurrence or death from cancer.

Results.
In the pooled stage II data set, ColoPrint identified 63% of patients as low risk with a 5-year ROR of 10%, whereas high-risk patients (37%) had a 5-year ROR of 21%, with a hazard ratio (HR) of 2.16 (p = .004). This remained significant in a multivariate model that included number of lymph nodes retrieved and microsatellite instability. In the T3 microsatellite-stable subgroup (n = 301), ColoPrint classified 59% of patients as low risk with a 5-year ROR of 9.9%. High-risk patients (31%) had a 22.4% ROR (HR: 2.41; p = .005). In contrast, the NCCN clinical high-risk factors were unable to distinguish high- and low-risk patients (15% vs. 13% ROR; p = .55).

Conclusion.
ColoPrint significantly improved prognostic accuracy independent of microsatellite status or clinical variables, facilitating the identification of patients at higher risk who might be considered for additional treatment.
Role of Positron Emission Tomography for the Monitoring of Response to Therapy in Breast Cancer
Authors: Humbert Olivier , Cochet Alexandre , Coudert Bruno , Berriolo-Riedinger Alina , Kanoun Salim , Brunotte François , Fumoleau Pierre 
Published: January 2015

Abstract
This review considers the potential utility of positron emission tomography (PET) tracers in the setting of response monitoring in breast cancer, with a special emphasis on glucose metabolic changes assessed with 18F-fluorodeoxyglucose (FDG). In the neoadjuvant setting of breast cancer, the metabolic response can predict the final complete pathologic response after the first cycles of chemotherapy. Because tumor metabolic behavior highly depends on cancer subtype, studies are ongoing to define the optimal metabolic criteria of tumor response in each subtype. The recent multicentric randomized AVATAXHER trial has suggested, in the human epidermal growth factor 2-positive subtype, a clinical benefit of early tailoring the neoadjuvant treatment in women with poor metabolic response after the first course of treatment. In the bone-dominant metastatic setting, there is increasing clinical evidence that FDG-PET/computed tomography (CT) is the most accurate imaging modality for assessment of the tumor response to treatment when both metabolic information and morphologic information are considered. Nevertheless, there is a need to define standardized metabolic criteria of response, including the heterogeneity of response among metastases, and to evaluate the costs and health outcome of FDG-PET/CT compared with conventional imaging. New non-FDG radiotracers highlighting specific molecular hallmarks of breast cancer cells have recently emerged in preclinical and clinical studies. These biomarkers can take into account the heterogeneity of tumor biology in metastatic lesions. They may provide valuable clinical information for physicians to select and monitor the effectiveness of novel therapeutics targeting the same molecular pathways of breast tumor.
Locally Advanced Gastroesophageal Junction Tumor: A Treatment Dilemma
Authors: Ashraf Noman , Hoffe Sarah , Kim Richard 
Published: January 2015

Abstract
Over the last several decades, the incidence of adenocarcinoma of the gastroesophageal junction (GEJ) has been increasing in developed countries. Although complete surgical resection remains the cornerstone of treatment for resectable disease, long-term outcomes are poor and recurrence rates are high with surgery alone in patients presenting with locally advanced disease. Multimodal therapy has been shown to improve survival; however, the optimal therapeutic approach remains controversial, and practices vary across the world. Preoperative chemoradiotherapy is generally used in the U.S., whereas perioperative chemotherapy without radiation is favored in most European countries. In this review, we discuss why the treatment of locally advanced GEJ tumors remains controversial, examine the evidence for various multimodal approaches, discuss their respective pros and cons, evaluate the role of radiation therapy, highlight some ongoing and planned clinical trials, and suggest areas that need further research.
A New Approach To Estimate Invasion Radius of Water-Based-Drilling-Fluid Filtrate To Evaluate Formation Damage Caused by Overbalanced Drilling
Authors: Ling Kegang , Zhang He , Shen Zheng , Ghalambor Ali , Han Guoqing , He Jun , Pei Peng 
Published: January 2015

SummaryFormation damage caused by overbalanced drilling with water-based mud (WBM) is inevitable as a result of mud filtrate invading the near-wellbore formation. The invasion radius is critical to the multiphase flow when the well is put on production. It contributes to the total skin that hinders the hydrocarbon production. Furthermore, the response of the logging tools may be affected as a result of such invasion, rendering many inaccurate calculations in formation evaluation. To evaluate the skin caused by mud-filtrate invasion, it is important to determine the radius of invasion. A thorough literature review indicated that no practical and reliable method with solid theoretical basis to quantify formation damage is available. Former studies assumed that single-phase drilling fluid displaces reservoir fluid during the invasion. The neglecting of residual reservoir fluid in the invaded zone will introduce error to invasion-radius estimation. This work takes the residual reservoir fluid into account; thus, the estimation of invasion radius is more accurate.This work proposes a practical model to determine the depth of mud-filtrate invasion near the wellbore drilled by WBM. The distribution of mud-filtrate saturation in the near-wellbore region is also calculated by using drilling-operation parameters, mud-filtration-test data, relative permeability, and drilling time. With the accurately determined invasion radius and known wellbore radius, reservoir permeability, and damaged-reservoir permeability, one can evaluate skin factor more accurately. With the knowledge of invasion volume and radius, one can design the wellbore-cleanup procedure appropriately. The proposed model allows engineers to predict the well performance and to diagnose wellbore problems by checking any deviation from the predicted production. This study also can assist with the correction of parameters inferred from log measurements, thereby reducing the over- and/or underestimation of log-derived parameters used in various formation-evaluation calculations.
The Opportunity Cost of Exploration for Unconventional Gas in Saudi Arabia
Authors: Casey Meaghan , Rajan Surya , Adejumo Adebola , Kugler Imre 
Published: January 2015

Abstract
Estimates place unconventional natural gas reserves in the Kingdom of Saudi Arabia at over 600 trillion cubic feet, more than double its proven conventional gas reserves. Domestic consumption fuels the economy as well as social spending, and the leadership is heavily invested in global research and development centers to become leading innovators in the industry. There is evidence of current commitment to develop natural gas projects in 3 offshore fields and construction of a 1, 000 MW gas-fired power plant. Despite political will for resource diversification in Saudi Arabia, there are hurdles in the form of processing capacity, logistics, water supplies and desert terrain, which could adversely affect project economics. Lifecycle economic analysis indicates that under current market conditions, development of unconventional gas projects could be challenging.
A breakeven economic analysis of the country's gas supply sources tests this supposition by assessing unconventional field development lifecycle costs and off-take pipeline infrastructure costs. Our analysis reveals that a breakeven price for domestic unconventional gas in Saudi Arabia ranges from roughly $5/Mcf to $8/Mcf depending on a range of pipeline scenarios. The study further explores several gas supply scenarios incorporating the commercialization of Saudi Arabia's unconventional resource assets, LNG imports, and pipeline imports from Qatar. In lieu of short-term unconventional gas supply, overall findings suggest pipeline gas from Qatar offers the lowest cost option, although LNG from Yemen or Nigeria ranks as a competitive resource alternative for additional near-term supply.
Culture and Rural Development: Voices from Poland
Authors: Gorlach Krzysztof , Klekotko Marta , Nowak Piotr 
Published: January 2015

Abstract
The paper is focused on the issue of culture and its connections to rural developments. It was based on the assumption that the culture has various impacts on rural communities` life, as well as, it has been present in various ways in functioning and changes that might be observed in rural areas. In our opinion, such a perspective should be presented in a more detailed way in order to stress the multiple and various impact of cultural issues on economic and social transformations in rural areas. Therefore, we divided our paper into three consecutive parts. In the first one, we discussed the multi-dimensional image of culture, and its role in human development. In the second one, we discussed some changes in the mechanisms of rural development, perceived as moving from the traditional to the contemporary one. We wanted to stress that culture seems to be an important part of the latter one. The last part of our considerations brought some empirical evidence from Poland focused on the role of culture in rural developments showing, at the same type, some examples of this new mechanism of rural development.
Politics in the Balkan countryside: case study in Serbia
Authors: Lukić Tamara , Penjišević Ivana , Đerčan Bojan , Đurđev Branislav , Živković Milka Bubalo , Armenski Tanja 
Published: January 2015

Abstract
Thanks to the field observations conducted on the territory of central Serbia, it was noticed that people in rural environment, beside the optional conversations about weather conditions, most often talk about the politics. The aim of this work was to find out how many people who live in the countryside have the contact with the politics. Hypothesis were made within the communication with several examinees, but they were verified by the poll in which more than 100 persons took part. Data were analyzed by descriptive statistics, using T-test, one-factor analysis of ANOVA variance, and also they were checked by Post-hoc Tukey test. The work task was to find out if gender, age, as well as, professional and regional differences exist in relation to the countryside inhabitants considerations about certain political issues they have been talking about. The importance of this work is to discover whether the distance from urban environments and, life in nature can make a man less interested in and indifferent to the politics.
Low-cost resonant cavity Raman gas probe for multi-gas detection
Authors: Thorstensen J. , Haugholt K. H. , Ferber A. , Bakke K. A. H. , Tschudi J. 
Published: January 2015

Raman based gas sensing can be attractive in several industrial applications, due to its multi-gas sensing capabilities and its ability to detect O2 and N2. In this article, we have built a Raman gas probe, based on low-cost components, which has shown an estimated detection limit of 0.5 % for 30 second measurements of N2 and O2. While this detection limit is higher than that of commercially available equipment, our estimated component cost is approximately one tenth of the price of commercially available equipment. The use of a resonant Fabry-Pérot cavity increases the scattered signal, and hence the sensitivity, by a factor of 50. The cavity is kept in resonance using a piezo-actuated mirror and a photodiode in a feedback loop.
The system described in this article was made with minimum-cost components to demonstrate the low-cost principle. However, it is possible to decrease the detection limit using a higher-powered (but still low-cost) laser and improving the collection optics. By applying these improvements, the detection limit and estimated measurement precision will be sufficient for e.g. the monitoring of input gases in combustion processes, such as e.g. (bio-)gas power plants. In these processes, knowledge about gas compositions with 0.1 % (absolute) precision can help regulate and optimize process conditions.
The system has the potential to provide a low-cost, industrial Raman sensor that is optimized for specific gas-detection applications.
Diffusion-weighted imaging–detected ischemic lesions associated with flow-diverting stents in intracranial aneurysms: safety, potential mechanisms, clinical outcome, and concerns
Authors: Iosif Christina , Camilleri Yann , Saleme Suzana , Caire François , Yardin Catherine , Ponomarjova Sanita , Boncoeur-Martel Marie-Paule , Mounayer Charbel 
Published: January 2015

OBJECT
It was initially considered safe for flow-diverting stents to cover the ostia of branching vessels during endovascular procedures for the treatment of intracranial aneurysms. As more recent evidence suggests, however, their use is not always free of ischemic concerns in terms of covered arterial ostia. The authors sought to determine the frequency of silent and clinically evident diffusion-weighted imaging (DWI)–detected abnormalities related to stent placement as a means of elucidating potential clinical risks.

METHODS
This is a prospective single-center study on a series of patients with intracranial aneurysms that were treated with flow-diverting stents. All patients systematically underwent an MRI protocol that included DWI before treatment, between 24 and 48 hours postprocedure, and 3 months postembolization. Effectiveness of anticoagulation treatment was assessed for all patients. Lesions seen on DWI were correlated to the parent artery and the side-branch territories and were statistically analyzed in relation to their time of occurrence and clinical presentation. The authors compared the DWI findings in these patients to findings obtained in patients treated with a stent-assisted coiling technique during the same time period.

RESULTS
Over the course of 18 consecutive months, 38 consecutive patients (7 males and 31 females) with 49 intracranial aneurysms were treated using flow-diverting stents. Overall, 81.6% of the DWI spots found remained clinically silent during the follow-up period. Five ischemic clinical complications (13.2%) occurred in the postprocedural period. No statistically significant correlation could be established between DWI spots or aneurysm location and clinical complications or follow-up modified Rankin Scale score at 3 months. The complication rate was 7.8% (n = 3) at the 3-month follow-up, and mortality was 0%. Compared with stent-assisted coiling, use of flow-diverting stents showed a statistically significant correlation with silent DWI findings postintervention.

CONCLUSIONS
Lesions seen on DWI resulting from the procedure are far more common than anticipated, but the technique remains safe and effective, providing an interesting alternative for “difficult” aneurysms, regardless of location. Late-occurring DWI-detected lesions distal to side arterial branches imply a local pressure gradient drop, related to flow competition by collateral networks. Further research is needed to assess the extent and significance of these events.
Les modes d'aménagement des terroirs et le dynamisme de la civilisation de l'oasis
Authors: Bensidoun Sylvain 
Published: January 2015

Sous la pression de causes économiques et politiques la civilisation de l'oasis subit de nos jours de larges transformations. Les terroirs se modifient, obéissant à un dynamisme que l'auteur se propose d'apprécier par l'étude des rapports entre les cultures et la pression démographique, la polyculture, l'association plus étroite entre les cultures et l'élevage.
Dans les limites géographiques de l'Islam les caractères originaux de la civilisation de l'oasis sont appréciés. C'est une civilisation agraire, fragile, sans cesse menacée par l'agressivité de certaines conditions physiques et économiques. Et sous la poussée de conditions politiques les oasis évoluent rapidement, en particulier dans l'Asie Moyenne soviétique.
Ainsi, la civilisation de l'oasis est entrée dans la phase de transformations inégales dans leur ampleur et leur durée. L'étude des terroirs, limitée aux oasis algériennes, permet d'apprécier le dynamisme selon des critères externes et internes qui, se combinant, pourraient se présenter sous forme de rapports numériques entre les antagonismes naturels et les forces favorables.
Multiscale stress–strain characterization of onion outer epidermal tissue in wet and dry states
Authors: Kim Keekyoung , Yi Hojae , Zamil M. Shafayet , Haque M. Amanul , Puri Virendra M. 
Published: January 2015

•Premise of the study:Quantitative measurements of water's effects on the tension response of plant tissue will assist in understanding the regulatory mechanism underlying expansive growth. Such measurements should be multiscale in nature to account for plants’ hierarchical structure.•Methods:Outer onion epidermal tissues were cut and bonded to uniaxial displacement‐controlled mechanical loading devices to apply and measure the force on the sample. Fluorescent polystyrene beads (500 nm in diameter) were dispersed on the sample surface under various levels of tensile load conditions to obtain displacement maps with a confocal fluorescent microscope. The resulting strain was measured using a digital image correlation technique by tracking individual bead displacements. The applied forces were obtained by measuring the displacement of the calibrated force‐sensing device. Tissue‐ and cell‐scale mechanical properties were quantified by calculating the applied stress and the corresponding global and local strains.•Key results:The Young's modulus values of individual cell walls of dehydrated and rehydrated samples were 3.0 ± 1.0 GPa and 0.4 ± 0.2 GPa, respectively, and are different from the Young's modulus values of the global tissue‐scale dehydrated and rehydrated samples, which were 1.9 ± 0.3 GPa and 0.08 ± 0.02 GPa, respectively. Poisson's ratio increased more than 3‐fold due to hydration.•Conclusion:The results on global, cell‐to‐cell, and point‐to‐point mechanical property variations suggest the importance of the mechanical contribution of extracellular features including the middle lamella, cell shape, and dimension. This study shows that a multiscale investigation is essential for fundamental insights into the hierarchical deformation of biological systems.
Prévenir l'exclusion scolaire et sociale des jeunes
Authors: Zay Danielle 
Published: January 2015

Les orientations théoriques de la recherche s’inscrivent, d’une part, dans un fort consensus des deux équipes, française et anglaise, sur le paradigme de la solidarité et le modèle scolaire propre aux zones défavorisées, celui d’une école partenaire des autres instances d’un quartier pour lutter contre l’exclusion scolaire et sociale et, d’autre part, dans une collaboration soutenue pour les enquêtes menées par chaque équipe sur le terrain de l’autre. Les divergences de conduite de la recherche et de résultats peuvent s’expliquer par d’autres choix propres à chacune des équipes, par exemple, la perspective beaucoup plus marquée d’éducation comparée des Anglais, mais aussi par des facteurs objectifs : différence de composition interne des deux équipes et influence des contraintes imposées par les politiques nationales dont dépendent les stratégies des acteurs régionaux, chercheurs inclus.
Prévenir l'exclusion scolaire et sociale des jeunes
Authors: Malet Régis , Lawes Shirley , Masson Philippe 
Published: January 2015

La France et l’Angleterre traduisent, chacune à sa façon, d’importants changements dans les programmes de formation des enseignants en Europe : la valorisation de l’expertise professionnelle et de la formation en situation, le développement de collaborations entre universitaires et praticiens et de prérogatives confiées aux seconds dans la formation et l’évaluation des enseignants. Ces orientations débouchent sur des pratiques nouvelles : stages, mémoire professionnel, tutorat, faisant apparaître de nouveaux acteurs à l’interface de la formation et de la profession : tuteurs, « mentors », supposés créer des ponts entre l’Université et le terrain professionnel. Dans une première partie, la construction de ces territoires de formation sera interrogée dans une perspective institutionnelle et socio-pédagogique comparée. Dans une seconde partie, nous chercherons à éclairer de façon comparative les modalités et les vertus singulières de l’accompagnement des enseignants-stagiaires par un tuteur ou un mentor au cours de leur stage en établissement scolaire, et de mesurer comment s’articulent sur le terrain les éléments prescriptifs propres à la définition de l’exercice tutoral et les relations concrètes qui se tissent dans les établissements entre tuteurs et stagiaires. L’ensemble de cette partie empirique est mené dans des établissements difficiles – dans le contexte, donc, de la prise en charge de publics dits « sensibles ».