bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sobre la construcción de la enfermedad en el discurso del malestar docente
Authors: Reyes Tamara , Varas Alejandro , Zelaya Víctor 
Published: July 2015

Esta investigación aborda el problema de la enfermedad como una narrativa del malestar docente, desde la perspectiva de las investigaciones discursivas, para comprender su relación con la producción de identidades en Chile. El estudio fue realizado con profesorxs1 pertenecientes al sistema público que ya participaron de la evaluación docente o se encontraban participando en dicho proceso. Los resultados proponen una narrativa canónica caracterizada por la construcción discursiva de la enfermedad. Se plantea una interpretación política de la construcción y producción de subjetividades en lo educativo, particularmente en el contexto del nuevo management público.
Violencia sufrida y percibida por el personal de enfermería del Área Sanitaria Integrada de A Coruña
Authors: Isasi Santiago Martinez , García Zurita Abelardo , Felipez Agrelo Iria María , Castro Dios Diana Josefa 
Published: July 2015

<br /><p><em></em>Introduccion: La violencia sufrida y percibida por el personal de Enfermería está en aumento desde hace dos décadas de manera global y ningún acto violento está justificado. Son muchas las consecuencias sobre la salud de las enfermeras como consecuencia de la violencia en el trabajo y múltiples variables que intervienen en la violencia y casi todas ya estudiadas.<br />Objetivo: Conocer y describir las agresiones percibidas y sufridas por el personal de enfermería en el EOXI A Coruña.<br />Material y métodos: Estudio descriptivo, transversal, de la información recogida a través de un cuestionario autoaplicado, individual y anónimo, llevado a cabo con el personal de enfermería del Área Sanitaria A Coruña.<br />Resultados: La participación ha sido del 14,5% de la muestra inicial. De los enfermeros que han cubierto la encuesta declaran haber sufrido una agresión el 68,3%, siendo la violencia verbal el tipo de mayor frecuencia (37,2%), seguido por la combinación de agresión verbal y física (18,6%). El 35,6% han sentido el respaldo de la empresa y únicamente han denunciado el 20% de los que han sido víctimas de violencia hacia su persona.<br />Conclusiones: Los actos violentos sufridos en los cuales se ha tramitado la denuncia son muy bajos. El conocerlos y trabajar sobre ellos en los diferentes contextos donde se producen y de manera piramidal en la organización haría que podamos luchar de manera eficiente contra este problema.</p><p> </p>
Encuesta de satisfacción de un proyecto de mejora de calidad del servicio aragonés de salud
Authors: Bimbela Serrano María Teresa , Bimbela Serrano Fernando , Bernués Vázquez Luis 
Published: July 2015

<p> Introducción: Según el informe de 2008 del Sistema Nacional de Salud, existe un 4,7% de los usuarios que opina que el sistema sanitario debería rehacerse por completo y casi un 27%, que es necesario introducir cambios importantes para su mejora.<br />Hipótesis: El desarrollo de un programa específico de control de peso para pacientes obesos en Atención Primaria mejora la calidad de la actuación percibida por el paciente de Atención Primaria.<br />Objetivos: Valorar la influencia de un proyecto de mejora de calidad de Atención Primaria en los resultados globales de una encuesta de satisfacción de los usuarios de dicha Zona Básica de Salud.<br />Material y Métodos: Estudio prospectivo de intervención cuasiexperimental centrado en el tratamiento de la obesidad en Atención Primaria realizado desde Enero de 2012 a Diciembre 2013, en cuya evaluación final se realizó una encuesta autoadministrada de Satisfacción de los usuarios y se comparó con los resultados obtenidos con el mismo cuestionario por el Servicio Aragonés de Salud en dicha Zona Básica de Salud. Para el análisis estadístico de estos datos se empleó el programa informático SPSS.15.<br />Resultados principales: Se observa un aumento destacable en los apartados “Interés del personal de enfermería”, “Satisfacción de los cuidados sanitarios” (medicina y enfermería) y “Solución dada a problemas”. No hubo aspectos negativos y el 100% de los encuestados expresó una satisfacción general y un 88% destacó el aspecto de la paciencia del profesional hacia los pacientes.</p><p>Conclusión: El proyecto de mejora de calidad realizado con pacientes crónicos de la consulta de enfermería de Atención Primaria, ha sido valorado muy satisfactoriamente, llegando a mejorar la puntuación de los resultados globales del Sistema Aragonés de Salud en esta Zona Básica de Salud.</p><p> </p>
Metal‐Free Decarboxylative Cyclization/Ring Expansion: Construction of Five‐, Six‐, and Seven‐Membered Heterocycles from 2‐Alkynyl Benzaldehydes and Cyclic Amino Acids
Authors: Samala Srinivas , Singh Gajendra , Kumar Ravi , Ampapathi Ravi Sankar , Kundu Bijoy 
Published: July 2015

AbstractA one pot synthesis of 1H‐benzo[g]indoles, tetrahydrobenzo[h]quinolines, and naphtho[1,2‐b]azepines from 2‐alkynyl benzaldehydes and cyclic amino acids is reported. The salient feature of the strategy involves formation of three new bonds (one CN and two CC bonds) by a metal‐free decarboxylation/cyclization/one‐carbon ring expansion sequence in one pot.
A potyvirus vector efficiently targets recombinant proteins to chloroplasts, mitochondria and nuclei in plant cells when expressed at the amino terminus of the polyprotein
Authors: Majer Eszter , Navarro José‐Antonio , Daròs José‐Antonio 
Published: July 2015

AbstractPlant virus‐based expression systems allow quick and efficient production of recombinant proteins in plant biofactories. Among them, a system derived from tobacco etch virus (TEV; genus potyvirus) permits coexpression of equimolar amounts of several recombinant proteins. This work analyzed how to target recombinant proteins to different subcellular localizations in the plant cell using this system. We constructed TEV clones in which green fluorescent protein (GFP), with a chloroplast transit peptide (cTP), a nuclear localization signal (NLS) or a mitochondrial targeting peptide (mTP) was expressed either as the most amino‐terminal product or embedded in the viral polyprotein. Results showed that cTP and mTP mediated efficient translocation of GFP to the corresponding organelle only when present at the amino terminus of the viral polyprotein. In contrast, the NLS worked efficiently at both positions. Viruses expressing GFP in the amino terminus of the viral polyprotein produced milder symptoms. Untagged GFPs and cTP and NLS tagged amino‐terminal GFPs accumulated to higher amounts in infected tissues. Finally, viral progeny from clones with internal GFPs maintained the extra gene better. These observations will help in the design of potyvirus‐based vectors able to coexpress several proteins while targeting different subcellular localizations, as required in plant metabolic engineering.
Involvement of Acidic Amino Acid Residues in Zn2+ Binding to Respiratory Complex I
Authors: Kriegel Sébastien , Srour Batoul , Steimle Stefan , Friedrich Thorsten , Hellwig Petra 
Published: July 2015

AbstractProton transfer across membranes and membrane proteins is a central process in biological systems. Zn2+ ions are capable of binding to acidic residues, often found within such specific pathways, thereby leading to a blockage. Here we probed Zn2+inhibition of the proton‐pumping NADH:ubiquinone oxidoreductase from Escherichia coli by means of electrochemically induced FTIR difference spectroscopy. Numerous conformational changes were identified including those that arise from the reorganization of the membrane arm upon electron transfer in the peripheral arm of the protein. Signals at very high wavenumbers (1781 and 1756 cm−1) point to the perturbation of acidic residues in a highly hydrophobic environment upon Zn2+ binding. In variant D563NL, which lacks part of the proton pumping activity (residue located on the horizontal amphipathic helix), the spectral signature of Zn2+ binding is changed. Our data support a role for this residue in proton translocation.
Cross‐Aldol Reaction of Isatin with Acetone Catalyzed by Leucinol: A Mechanistic Investigation
Authors: Kabeshov Mikhail A. , Kysilka Ondřej , Rulíšek Lubomír , Suleimanov Yury V. , Bella Marco , Malkov Andrei V. , Kočovský Pavel 
Published: July 2015

AbstractComprehensive mechanistic studies on the enantioselective aldol reaction between isatin (1 a) and acetone, catalyzed by L‐leucinol (3 a), unraveled that isatin, apart from being a substrate, also plays an active catalytic role. Conversion of the intermediate oxazolidine 4 into the reactive syn‐enamine 6, catalyzed by isatin, was identified as the rate‐determining step by both the calculations (ΔG≠=26.1 kcal mol−1 for the analogous L‐alaninol, 3 b) and the kinetic isotope effect (kH/kD=2.7 observed for the reaction using [D6]acetone). The subsequent reaction of the syn‐enamine 6 with isatin produces (S)‐2 a (calculated ΔG≠=11.6 kcal mol−1). The calculations suggest that the overall stereochemistry is controlled by two key events: 1) the isatin‐catalyzed formation of the syn‐enamine 6, which is thermodynamically favored over its anti‐rotamer 7 by 2.3 kcal mol−1; and 2) the high preference of the syn‐enamine 6 to produce (S)‐2 a on reaction with isatin (1 a) rather than its enantiomer (ΔΔG≠=2.6 kcal mol−1).
Towards Self‐Assembled Hybrid Artificial Cells: Novel Bottom‐Up Approaches to Functional Synthetic Membranes
Authors: Brea Roberto J. , Hardy Michael D. , Devaraj Neal K. 
Published: July 2015

AbstractThere has been increasing interest in utilizing bottom‐up approaches to develop synthetic cells. A popular methodology is the integration of functionalized synthetic membranes with biological systems, producing “hybrid” artificial cells. This Concept article covers recent advances and the current state‐of‐the‐art of such hybrid systems. Specifically, we describe minimal supramolecular constructs that faithfully mimic the structure and/or function of living cells, often by controlling the assembly of highly ordered membrane architectures with defined functionality. These studies give us a deeper understanding of the nature of living systems, bring new insights into the origin of cellular life, and provide novel synthetic chassis for advancing synthetic biology.
β‐Octamethoxy‐Substituted 22π and 26π Stretched Porphycenes: Synthesis, Characterization, Photodynamics, and Nonlinear Optical Studies
Authors: Rana Anup , Lee Sangsu , Kim Dongho , Panda Pradeepta K. 
Published: July 2015

AbstractThree meso‐expanded tetrapyrrolic aromatic macrocycles, including 22π and 26π acetylene–cumulene bridged stretched octamethoxyporphycenes and octamethoxy[22]porphyrin‐(2.2.2.2), are reported, for the first time, by modification of previously reported synthetic methods. This strategy led to an enhancement in the overall yield of their corresponding octaethyl analogues. The methoxy‐substituted expanded porphycenes display slightly blueshifted absorption relative to their ethyl analogues, along with very weak fluorescence, probably due to efficient intramolecular charge transfer (ICT). Additionally, the two‐photon absorption (TPA) cross sections of these macrocycles were evaluated; these are strongly related to core expansion of the porphyrin aromaticity through increased meso‐bridging carbon atoms as well as conformational flexibility and substitution effects at the macrocyclic periphery. In particular, the octamethoxy stretched porphycenes display strong TPA compared with the octaethyl analogues due to the dominant ICT character of methoxy groups with a maximum TPA cross section of 830 GM at 1700 nm observed for 26π‐octamethoxyacetylene–cumuleneporphycene.
Transparent Carbon Nanotube Network for Efficient Electrochemiluminescence Devices
Authors: Valenti Giovanni , Zangheri Martina , Sansaloni Sandra E. , Mirasoli Mara , Penicaud Alain , Roda Aldo , Paolucci Francesco 
Published: July 2015

AbstractA carbon nanotube‐based electrode that combines transparency and good conductivity was used for the first time to develop an electrochemiluminescence (ECL) device. It resulted in an excellent material for ECL applications thanks to the very favorable overpotential of amine oxidation that represents the rate‐determining step for the signal generation in both research systems and commercial instrumentation. The use of carbon nanotubes resulted in a ten times higher emission efficiency compared with commercial transparent indium tin oxide (ITO) electrodes. Moreover, application of this material for proof‐of‐principle ECL imaging was demonstrated, in which micro‐beads were used to mimic a real biological sample in order to prove the possibility of obtaining single cell visualization.
Randomized controlled trial of irinotecan drug‐eluting beads with simultaneous FOLFOX and bevacizumab for patients with unresectable colorectal liver‐limited metastasis
Authors: Martin Robert C. G. , Scoggins Charles R. , Schreeder Marshall , Rilling William S. , Laing Christopher J. , Tatum Clifton M. , Kelly Lawrence R. , Garcia‐Monaco Ricardo D. , Sharma Vivek R. , Crocenzi Todd S. , Strasberg Steven M. 
Published: July 2015

BACKGROUNDReports have demonstrated the superior activity of combining both irinotecan and oxaliplatin (FOLFOXIRI) therapy. An option for gaining similar benefits with less toxicity would be the administration of irinotecan through a hepatic artery approach. The aim of this study was to assess the response and adverse event rates for irinotecan drug‐eluting beads (DEBIRI) with folinic acid, 5‐fluorouracil, and oxaliplatin (FOLFOX) and bevacizumab as a first‐line treatment for unresectable colorectal liver metastasis.METHODSPatients with colorectal liver metastases were randomly assigned to modified FOLFOX (mFOLFOX) and bevacizumab or mFOLFOX6, bevacizumab, and DEBIRI (FOLFOX‐DEBIRI). The primary endpoint was the response rate. The secondary endpoints were adverse events, the rate of conversion to resection, and progression‐free survival.RESULTSThe intention‐to‐treat population comprised 70 patients: 10 patients in the pilot and then 30 patients randomly assigned to the FOLFOX‐DEBIRI arm and 30 patients randomly assigned to the FOLFOX/bevacizumab arm. The 2 groups were similar with respect to the extent of liver involvement (30% vs 30%), but a greater percentage of patients in the FOLFOX‐DEBIRI arm had an Eastern Cooperative Oncology Group performance status of 1 or 2 (57% vs 31%) and extrahepatic disease (56% vs 32%, P = .02). The median numbers of chemotherapy cycles were similar (10 vs 9), and there were similar rates of grade 3/4 adverse events (54% for the FOLFOX‐DEBIRI group vs 46% for the FOLFOX/bevacizumab group). The overall response rate was significantly greater in the FOLFOX‐DEBIRI arm versus the FOLFOX/bevacizumab arm at 2 (78% vs 54%, P = .02), 4 (95% vs 70%, P = .03), and 6 months (76% vs 60%, P = .05). There was significantly more downsizing to resection in the FOLFOX‐DEBIRI arm versus the FOLFOX/bevacizumab arm (35% vs 16%, P = .05), and there was improved median progression‐free survival (15.3 vs 7.6 months).CONCLUSIONSThe simultaneous administration of mFOLFOX6 (with or without bevacizumab) and DEBIRI through the hepatic artery (FOLFOX‐DEBIRI) is safe and does not cause treatment delays or increase the systemic toxicity of chemotherapy. This strategy leads to improved overall response rates, improved hepatic progression‐free survival, and more durable overall progression‐free survival in patients downsized to resection. Cancer 2015. © 2015 American Cancer Society. Cancer 2015;121:3649–3658. © 2015 American Cancer Society.
Prostate cancer, comorbidity, and the risk of venous thromboembolism: A cohort study of 44,035 Danish prostate cancer patients, 1995‐2011
Authors: Ording Anne G. , Horváth‐Puhó Erzsébet , Lash Timothy L. , Ehrenstein Vera , Borre Michael , Vyberg Mogens , Sørensen Henrik T. 
Published: July 2015

BACKGROUNDVenous thromboembolism (VTE) is a serious complication of cancer. It is unknown whether comorbidity interacts clinically with prostate cancer (PC) to increase the VTE rate beyond that explained by PC and comorbidity alone, for example, by delaying diagnosis or precluding treatment.METHODSA nationwide, registry‐based cohort study of all 44,035 Danish patients diagnosed with PC from 1995 to 2011 and 213,810 men from the general population matched 5:1 on age, calendar time, and comorbidities. The authors calculated VTE rate ratios and the interaction contrast as a measure on the additive scale of the excess VTE rate explained by synergy between PC and comorbidity.RESULTSIn total, 849 patients in the PC cohort and 2360 men from the general population had VTE during 5 years of follow‐up, and their risk of VTE was 2.2% and 1.3%, respectively. The 1‐year VTE standardized rate among PC patients who had high comorbidity levels was 15 per 1000 person‐years (PYs) (95% confidence interval, 6.8‐24 per 1000 PYs), and 29% of that rate was explained by an interaction between PC and comorbidity. The VTE risk was increased among older patients, those with metastases, those with high Gleason scores, those in the D'Amico high‐risk group, and those who underwent surgery.CONCLUSIONSPC interacted clinically with high comorbidity levels and increased the VTE rate. Because of the large PC burden, reducing VTEs associated with comorbidities may have an impact on VTE risk and the potential to improve prognosis. Clinical interactions between high levels of comorbidity and PC on the risk of VTE were observed. Almost 30% of all episodes of VTE occurred among patients who had high levels of comorbidity. Cancer 2015;121:3692–3699. © 2015 American Cancer Society.
Strongly Coupled PtNi0.3Co2.7O4 Hybrid Nanoflowers with Remarkably Enhanced Catalytic Performance
Authors: Wang Xiao , Liu Dapeng , Wang Fan , Li Junqi , Zhen Jiangman , Zhang Hongjie 
Published: July 2015

AbstractThe nonstoichiometric metal oxide Ni0.3Co2.7O4 served as a support for small‐sized Pt nanoparticles. The whole synthesis of the hybrid material can be kinetically controlled and no further surface‐modification treatment was required. More importantly, the as‐obtained strongly coupled PtNi0.3Co2.7O4 hybrid nanoflowers exhibit remarkably enhanced catalytic activities compared with PtNiO and PtCo3O4 hybrid samples. This result indicates that it is possible to optimize the catalytic performance of noble metals by using a nonstoichiometric metal oxides as a support instead of a stoichiometric metal oxide.
Mouse Genome Database: From sequence to phenotypes and disease models
Authors: Eppig Janan T. , Richardson Joel E. , Kadin James A. , Smith Cynthia L. , Blake Judith A. , Bult Carol J. ,   the MGD Team
Published: July 2015

SummaryThe Mouse Genome Database (MGD, www.informatics.jax.org) is the international scientific database for genetic, genomic, and biological data on the laboratory mouse to support the research requirements of the biomedical community. To accomplish this goal, MGD provides broad data coverage, serves as the authoritative standard for mouse nomenclature for genes, mutants, and strains, and curates and integrates many types of data from literature and electronic sources. Among the key data sets MGD supports are: the complete catalog of mouse genes and genome features, comparative homology data for mouse and vertebrate genes, the authoritative set of Gene Ontology (GO) annotations for mouse gene functions, a comprehensive catalog of mouse mutations and their phenotypes, and a curated compendium of mouse models of human diseases. Here, we describe the data acquisition process, specifics about MGD's key data areas, methods to access and query MGD data, and outreach and user help facilities. genesis 53:458–473, 2015. © 2015 The Authors. Genesis Published by Wiley Periodicals, Inc.
Factor Structure of the Binge Eating Scale in a Large Sample of Obese and Overweight Patients Attending Low Energy Diet Therapy
Authors: Imperatori Claudio , Innamorati Marco , Lamis Dorian A. , Contardi Anna , Continisio Massimo , Castelnuovo Gianluca , Manzoni Gian Mauro , Fabbricatore Mariantonietta 
Published: July 2015

AbstractIn the present study, we evaluated the dimensionality and psychometric properties of the Italian version of the Binge Eating Scale (BES) in a 669 (127 men and 542 women) obese and overweight patients seeking weight loss treatment. All participants were administered the Italian version of the BES. Fit statistics for the alternative SEM models demonstrated that both the one‐factor and competing two‐factor models had a comparable fit to the data. Thus, we selected the one‐factor model as the most parsimonious. The BES had good internal consistency reliability (α = 0.89) with a moderate mean inter‐item correlation (rii = 0.34). Given that we were not able to clearly determine the best model among the competing two‐factor models and a comparable fit of these models with the one‐factor model, we have suggested that the one‐factor model is the best fitting model describing the dimensionality of the BES. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
A neural mediator of human anxiety sensitivity
Authors: Harrison Ben J. , Fullana Miquel A. , Soriano‐Mas Carles , Via Esther , Pujol Jesus , Martínez‐Zalacaín Ignacio , Tinoco‐Gonzalez Daniella , Davey Christopher G. , López‐Solà Marina , Pérez Sola Victor , Menchón José M. , Cardoner Narcís 
Published: July 2015

AbstractAdvances in the neuroscientific understanding of bodily autonomic awareness, or interoception, have led to the hypothesis that human trait anxiety sensitivity (AS)—the fear of bodily autonomic arousal—is primarily mediated by the anterior insular cortex. Despite broad appeal, few experimental studies have comprehensively addressed this hypothesis. We recruited 55 individuals exhibiting a range of AS and assessed them with functional magnetic resonance imaging (fMRI) during aversive fear conditioning. For each participant, three primary measures of interest were derived: a trait Anxiety Sensitivity Index score; an in‐scanner rating of elevated bodily anxiety sensations during fear conditioning; and a corresponding estimate of whole‐brain functional activation to the conditioned versus nonconditioned stimuli. Using a voxel‐wise mediation analysis framework, we formally tested for ‘neural mediators’ of the predicted association between trait AS score and in‐scanner anxiety sensations during fear conditioning. Contrary to the anterior insular hypothesis, no evidence of significant mediation was observed for this brain region, which was instead linked to perceived anxiety sensations independently from AS. Evidence for significant mediation was obtained for the dorsal anterior cingulate cortex—a finding that we argue is more consistent with the hypothesized role of human cingulofrontal cortex in conscious threat appraisal processes, including threat‐overestimation. This study offers an important neurobiological validation of the AS construct and identifies a specific neural substrate that may underlie high AS clinical phenotypes, including but not limited to panic disorder. Hum Brain Mapp 36:3950–3958, 2015. © 2015 Wiley Periodicals, Inc.